wanglab/gogpt-training-data huggingface dataset:
Protein: Probable amino-acid metabolite efflux pump (P31125)
Organism: Escherichia coli (strain K12)
Function: May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O-acetyl-L-serine (OAS)), and for other amino acids and their metabolites.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Cysteine/O-acetylserine efflux protein
- Protein RarD
- Uncharacterized MFS-type transporter YdeE
Sequence:
MSRKDGVLALLVVVVWGLNFVVIKVGLHNMPPLMLAGLRFMLVAFPAIFFVARPKVPLNLLLGYGLTISFAQFAFLFCAINFGMPAGLASLVLQAQAFFTIMLGAFTFGERLHGKQLAGIALAIFGVLVLIEDSLNGQHVAMLGFMLTLAAAFSWACGNIFNKKIMSHSTRPAVMSLVIWSALIPIIPFFVASLILDGSATMIHSLVTIDMTTILSLMYLAFVATIVGYGIWGTLLGRYETWRVAPLSLLVPVVGLASAALLLDERLTGLQFLGAVLIMTGLYINVFGLRWRKAVKVGS
Protein: EF-hand domain-containing protein (H9G2Y1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MGADASLPMEMCSNFDAYELRRLTRRFKKLDVDGSGSLSVEEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNTKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVGTLDIHEKMVVKV
Protein: Repressor of RNA polymerase III transcription (Q8RXT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037240}.
Interaction partners:
Sequence:
MKFLEYTNLDRLNVFLGHLNLGERTIKGCLEAYSCKHAGSDKRLSLSLENEMLDYLGKSSDTDSSSPVDLLLSRSSRKALIYLVLTLYQMYPDYDFSAVKAHQFFSEESWDTFKQIFNNYMFEASKEWTERNEDGSLLEVIYKALDEVVKLAECEIYVYNPNPNADPFLEEGAIWSFCFLFYNRKLKRVAGFRFSCTSNLANDAFLTDSPPYEEDEEIFADMDM
Protein: IL-1 receptor I (Interleukin 1 receptor type 1) (Q90874)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MHKMTSTFLLIGHLILLIPLFSAEECVICNYFVLVGEPTAISCPVITLPMLHSDYNLTWYRNGSNMPITTERRARIHQRKGLLWFIPAALEDSGLYECEVRSLNRSKQKIINLKVFKNDNGLCFNGEMKYDQIVKSANAGKIICPDLENFKDEDNINPEIHWYKECKSGFLEDKRLVLAEGENAILILNVTIQDKGNYTCRMVYTYMGKQYNVSRTMNLEVKESPLKMRPEFIYPNNNTIEVELGSHVVMECNVSSGVYGLLPYWQVNDEDVDSFDSTYREQFYEEGMPHGIAVSGTKFNISEVKLKDYAYKFFCHFIYDSQEFTSYIKLEHPVQNIRGYLIGGGISLIFLLFLILIVYKIFKIDIVLWYRSSCHPLLGKKVSDGKIYDAYVLYPKNRESCLYSSDIFALKILPEVLERQCGYNLFIFGRNDLAGEAVIDVTDEKIHQSRRVIIILVPEPSCYGILEDASEKHLAVYNALIQDGIKIILIELEKIEDYANMPESIKYVKQKYGAIRWTGDFSERSHSASTRFWKKVRYHMPSRKHGSSSGFHLSS
Protein: SD07613p (Q960C7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCIFIDCLLSPLIMWPATIGVGIYFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTKDGYELQLGVNHIGHFLLTNLLLDVLKNSAPSRIVVVSSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGSGVTVNALHPGVVDTELARNWAFFQTNLVKFFLKPMIWPLLKTPKSGAQTSIYAALDPELKNISGLYFSDCKPKPVAPGALDDKVAKFLWAESEKWTGLDKLEANN
Protein: Intersectin-2 (EH domain and SH3 domain regulator of endocytosis 2) (EH and SH3 domains protein 2) (SH3 domain-containing protein 1B) (Q9Z0R6)
Organism: Mus musculus (Mouse)
Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Epidermal growth factor receptor substrate 15
- AP-2 complex subunit mu
- F-BAR domain only protein 1
- AP-2 complex subunit sigma
- AP-2 complex subunit beta
- Cell division control protein 42 homolog
- AP-4 complex subunit beta-1
- AP-1 complex subunit beta-1
- Epidermal growth factor receptor substrate 15-like 1
- F-BAR domain only protein 2
Sequence:
MMAQFPTAMNGGPNMWAITSEERTKHDKQFDNLKPSGGYITGDQARTFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIHQPLPPVAPIATPLSSATSGTSIPPLMMPAPLVPSVSTSSLPNGTASLIQPLSIPYSSSTLPHASSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPSRLKYRQKFNSLDKGMSGYLSGFQARNALLQSNLSQTQLATIWTLADIDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQVDSVNGTLPSYQKTQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQVLMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKEIERREAAKQELERQRRLEWERLRRQELLSQKTREQEDIVRLSSRKKSLHLELEAVNGKHQQISGRLQDVQIRKQTQKTELEVLDKQCDLEIMEIKQLQQELKEYQNKLIYLVPEKQLLNERIKNMQLSNTPDSGISLLHKKSSEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRESYNTQQLALEQLHKIKRDKLKEIERKRLEQIQKKKLEDEAARKAKQGKENLWRESIRKEEEEKQKRLQEEKSQDKTQEEERKAEAKQSETASALVNYRALYPFEARNHDEMSFSSGDIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEKVLSSEKALSPKKALLPPTVSLSATSTSSQPPASVTDYHNVSFSNLTVNTTWQQKSAFTRTVSPGSVSPIHGQGQAVENLKAQALCSWTAKKENHLNFSKHDVITVLEQQENWWFGEVHGGRGWFPKSYVKLIPGNEVQRGEPEALYAAVTKKPTSTAYPVTSTAYPVGEDYIALYSYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGERTGIFPSNYVRPKDQENFGNASKSGASNKKPEIAQVTSAYAASGTEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERTMPTFHAVCQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQGETNGLTGLFPSNYVKMTTDSDPSQQWCADLQALDTMQPTERKRQGYIHELIQTEERYMDDDLQLVIEVFQKRMAEEGFLTEADMALIFVNWKELIMSNTKLLRALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGATLLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPQSHVDHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHAFLFNDFLLLTYLVRQFAAASGHEKLFNSKSSAQFRMYKTPIFLNEVLVKLPTDPSGDEPVFHISHIDRVYTLRTDNINERTAWVQKIKGASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEVSMGSQSYTTRTLQDTLNPKWNFNCQFFIKDLYQDVLCLTMFDRDQFSPDDFLGRTEVPVAKIRTEQESKGPTTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
Protein: ATP-dependent DNA helicase srs2 (EC 5.6.2.4) (DNA 3'-5' helicase srs2) (Q10213)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein rhp51
- ATP-dependent DNA helicase hus2/rqh1
- DNA repair protein rhp57
- Crossover junction endonuclease mus81
- DNA repair and recombination protein rad22
- DNA repair protein rhp54
- Telomere length regulation protein elg1
- Proliferating cell nuclear antigen
- ATP-dependent DNA helicase fml1
- DNA repair protein rhp55
Sequence:
METKSSYLKFLNEEQRISVQSPHKYTQILAGPGSGKTRVLTARVAYLLQKNHIAAEDLIIATFTNKAANEIKLRIEAILGNSEASKLISGTFHSIAYKYLVKYGKHIGLSSNWLIADRNDTQAIMKRLLDSLKKAKNPIASGIRGQELTPQNALNRITKLKSNGLLVKPGMDQLSLINGLEEPPKELQSHQSVELYRLYQTSLWKNNLADFDDLLLNFILLLQKQPDCVRNIKHILIDEFQDTSKIQYFLVKLLALQNSDITIVGDPDQSIYGFRSAEIRNLNQMSEDFEGTQVLHLERNYRSAKPILELALSIISQDKSRPKKGLKSNHISSLKPHYRLFETNNKESYWIAREIKRIVGSCPELIFYNDIAILVRSSSLTRSLEHALSELGVPYRMVGVNKFFDREEIRDLIAYLRVLANKDSTSLIRVINVPPRNIGKTKIDRIIFESERRGLTFWQTLNEVKNENILLSQRNDKSFLKSLKSFLCSISKLENRYLSNGHSATLSDLLLGILSEIKYYEYLVRKNKETVEEKWENVMELVQQSDNISCIFYELDYKISTIVLLQNFLTQIALVNEEQKEGESQKVTISTLHAAKGLEWPVVFLPCLCENIIPHSRSDDLDEERRLLYVGATRAQALLYLSSFKSVTGMFADMQNSDNVQDVSPFLKGEEMKRWVMESEIVFNEKIASEIGTILGRKSYGKITNLSGIGSNANHNGTKFENLGFQCCRVLAEAELKKRERVKSVNDYNKDETNFRKHNAKRSKTDIRSWFEKKQPIDSDVEISEPSRSASIMVANKDLNDRSFETVNRIVSTRASTTNASFMSSVRQNLGRGPSTKDQVINRTLREGHQDVVQHTDLNQSNTKVASARPAGSRKRLGVRLRVSRML
Protein: Acetylglutamate kinase (EC 2.7.2.8) (N-acetyl-L-glutamate 5-phosphotransferase) (NAG kinase) (NAGK) (Q6V1L5)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00082}.
Interaction partners:
- N-acetyl-gamma-glutamyl-phosphate reductase
- Arginine biosynthesis bifunctional protein ArgJ
- Nitrogen regulatory protein P-II
- Acetylornithine aminotransferase
- Ornithine carbamoyltransferase
- Argininosuccinate lyase
- Argininosuccinate synthase
- PipX
- Global nitrogen regulator
- TPR repeat
Sequence:
MSSEFIEAGAADRVRILSEALPYLQQFAGRTVVVKYGGAAMKQEELKEAVMRDIVFLACVGMRPVVVHGGGPEINAWLGRVGIEPQFHNGLRVTDADTMEVVEMVLVGRVNKDIVSRINTTGGRAVGFCGTDGRLVLARPHDQEGIGFVGEVNSVNSEVIEPLLERGYIPVISSVAADENGQSFNINADTVAGEIAAALNAEKLILLTDTRGILEDPKRPESLIPRLNIPQSRELIAQGIVGGGMIPKVDCCIRSLAQGVRAAHIIDGRIPHALLLEIFTDAGIGTMIVGSGYHEAHQPWQ
Protein: sphingomyelin phosphodiesterase (EC 3.1.4.12) (F1N588)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Sphingomyelin phosphodiesterase 4
- Ceramide glucosyltransferase
- Sphingomyelin phosphodiesterase
- Sphingomyelin phosphodiesterase 3
- Sphingomyelin synthase 2
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Sphingolipid delta
- sphingosine N-acyltransferase
- sphingosine N-acyltransferase
- Ceramide kinase
Sequence:
MHGTECCWLAMPARGDSWGHKHCASPGQPRRGPAPAARGGKGGRGDGRGGRRRPGLSSTLRLLLSNRRRGWRGPIGSRHQGRASEKRNAESTSRVPQSGSPLPRTSSGSPHPGSPQPPPPLGSLWDRPGSSSAAVASGACTWAPRPSGERGSRAATCTQCPGRTAARPCPPPRPSLWRPNRPAPPSVPAMKPNFTLRLRVFNLNCWGIPYLSKHRADRVKRLGDFLNMESFDLALLEEVWSEQDFQYLRQKLLPTYPAAHYFRSGIIGSGLCVFSKHPIQEFTQHVFTLNGYPYMIHHCDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYNRQKDTYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNLHPKDLGCRLLKEWTGLHDAYLETRDFKGSEEGCTMVPKNCYVKHQELGPFPLGIRIDYVLYKAVSGLYIFCKTFKTTTGHDPYSGPPFSDHEALMATLCVRHSPPQHNPSPTHGPAESSPLTSVLREAWAEVDQGMAQAHWWATMAGYAVGLGLLLLALLCALAAGGWIREAALLLWTPSVGLVLGAGAFYLFHVQEAKGLCRTRAELQHVLGRAREAQDLGPESQPALLLGQQERERAEEQ
Protein: FUN14 domain-containing protein 1 (Q5BJS4)
Organism: Rattus norvegicus (Rat)
Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IVP5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IVP5}.
Interaction partners:
- Gamma-aminobutyric acid receptor-associated protein
- Microtubule-associated protein 1 light chain 3 alpha
- Microtubule-associated protein 1 light chain 3 beta
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- Microtubule-associated protein 1 light chain 3 beta
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
- BCL2 interacting protein 3
- Serine/threonine-protein kinase
- BCL2/adenovirus E1B interacting protein 3-like.
- Gamma-aminobutyric acid receptor-associated protein-like 1
Sequence:
MASRNPPPQDYESDDESYEVLDLTEYARRHHWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQVASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNIIEEATDFIKQNIVISSGFVGGFLLGLAS
Protein: PHO85 cyclin-1 (Cyclin HCS26) (G1/S-specific cyclin PCL1) (P24867)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14688790}. Nucleus {ECO:0000269|PubMed:14688790}. Note=Localizes to the incipient bud site.
Interaction partners:
- Cyclin-dependent protein kinase PHO85
- PHO85 cyclin-2
- PHO85 cyclin-9
- G1/S-specific cyclin CLN1
- PHO85 cyclin CLG1
- Probable transcription factor HMS1
- Cyclin-dependent kinase 1
- G1/S-specific cyclin CLN2
- G1/S-specific cyclin CLN3
Sequence:
MCEYSKALHILLKSPVTDDIIKFLTDTTLRVVPSSNYPTPPGSPGEKHLTRLPSLMTFITRLVRYTNVYTPTLLTAACYLNKLKRILPRDATGLPSTIHRIFLACLILSAKFHNDSSPLNKHWARYTDGLFTLEDINLMERQLLQLLNWDLRVNTEDLILDLQPLLEPIKQDLARSSDQRKRINMMMSMNRRTCAGTSPIRSNNRFKLYEKQRNVSIASDLSSATLVDSCNDLRRLKDVTNIANNTVANTNYVRTVEKWNDNVNRQSWDLEQIMSQHGF
Protein: Putative redox protein fmp46, mitochondrial (EC 1.-.-.-) (Q9UTA2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MFGLTTKRILTLFTKKRQTLVEQKLTEYMIAGEKTDNQMLHFKLQVETATPTLDQLNIMLSNIGKDKSDLLVAGATSIEDALTKYQHDNQLFRRPCLVDWDKGKVSPYSILLQTRDFSKLL
Protein: D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) (P14920)
Organism: Homo sapiens (Human)
Function: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Subcellular location: Peroxisome matrix {ECO:0000269|PubMed:17684499, ECO:0000269|PubMed:18544534, ECO:0000269|PubMed:20368421, ECO:0000269|PubMed:21679769, ECO:0000269|PubMed:23219954, ECO:0000269|PubMed:31799256, ECO:0000305|PubMed:17880399, ECO:0000305|PubMed:29274788}. Cytoplasm, cytosol {ECO:0000269|PubMed:18544534, ECO:0000269|PubMed:21679769, ECO:0000269|PubMed:31799256}. Presynaptic active zone {ECO:0000250|UniProtKB:O35078}. Secreted {ECO:0000269|PubMed:27670111}. Note=Transiently present in the cytosol before being delivered to the peroxisomes (PubMed:21679769, PubMed:31799256). In the cerebellum, a fraction of protein localizes to the presynaptic active zone, where its activity is regulated by protein BSN (By similarity). Secreted into the lumen of the small intestine (PubMed:27670111). {ECO:0000250|UniProtKB:O35078, ECO:0000269|PubMed:21679769, ECO:0000269|PubMed:27670111, ECO:0000269|PubMed:31799256}.
Interaction partners:
- D-amino acid oxidase regulator
- Glycine dehydrogenase
- Sarcosine dehydrogenase, mitochondrial
- Alanine--glyoxylate aminotransferase
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- Peroxisomal sarcosine oxidase
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Trans-3-hydroxy-L-proline dehydratase
- 5-aminolevulinate synthase, non-specific, mitochondrial
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
Protein: Ring finger protein 111 (H0YKK5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHVFSLIDGSSGLAVLRLSLKFPMSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLVVRKKRKSQQAGPSYV
Protein: Adhesin AWP3b (B4UN32)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: May play a role in cell adhesion.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:18806209}. Note=May be GPI-anchored. {ECO:0000303|PubMed:18806209}.
Interaction partners:
Sequence:
MISFVTLLAILGLLSISWADQTVRSVAGDQRVTDPVIVGDNSILDYYGGSNYDFSNNFEIGRGTLYIGKESYFSSFQSAPTDVPNSFHLLIKNTNNLQNNGQFIIENIKRHANQCSNSSIQVFPINFQNDGEFEIISGGVEGRCCLPTSVIAPQNFLNNGKFYYKVLTDTGSIYSGSCMQNVDIGASTTTTVNNNLWEFTGSINAQINGAVSGAAQINLDGSNMFVNANTFSGQVVNLINGGSFLQTSDPLSNIVVINGLGTSDTGVTSIAVKGKGKSFTYNPSSGIVKLTTVEGKTYAYQIGCGYNTKKFITNNDSGASYESADNFFVLTYSEPYSPQTCQLENSSIFSSNFISTSTSSSSSSSSASSLPSSMSSSLPSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYGPHTHSSVSTPSSSSESSTTSNSSIESSSLPHTSVSSTPESSITPSSNTISSSPTSDFSSVQSSSIMESSSVVASSSVINSSSIVDSSSSSASSLPSSMSSSLSSSMSSSLPSSMSSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYGPHTHSSVSTPSSSSESSTTSNSSIESSSLPHTSVSSTPESSITPSSNTISSSPTSDFSSVQSSSIMESSSVVASSSVINSSSIVDSSSSSASSLPSSMPSSLPSSMSSSLSSSMSSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYGPHTHSSVSTPSSSSESSTTSNSSIESSSLPHTSVSSTPESSITPSSNTISSSPTSDFSSVQSSSIMESSSVVASSSATQSSSVINSSSIVDSSSSSASSLPSSMPSSLPSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYESSIYSSSSSTIQESELSNTSRTTMTSNSSVSISSTSSRSSFSNTKSSTIVISQSASLPDSKTDIILSTSSNIGYSSRSLLSDLGTSISDSDIHHSVLHSTESYSSNESGTNPFTSIASLSNFIPESSSHTSTALGSENSVISSDILTTMSHPVATNSGDKPTTPKRSEQVSTTMTSSGPTPDTSSFDTDGMSAYSRPEFTTNSLEVNKSSTSQLGNNKQTFSNLQLESTRPHSENEVDNNTRLLQSIQQSSTYGTNNVNPLSPTGSISIPLTEDGQGDNNNWNSPATNDLCTQISFNLTATTITVTDRITITDSIHDISSEVITSYIYQTIVDQKTVTQTVDGKSLANKMSSIPKPSSRSLIQPQPPVAIELQEGAASTSRVSLVSLFISIILVLL
Protein: 4-nitrophenylphosphatase (PNPPase) (EC 3.1.3.41) (Q00472)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Thiamine-repressible acid phosphatase pho4
- L-ornithine N
- Uncharacterized transcriptional regulatory protein C27B12.11c
Sequence:
MAKKLSSPKEYKEFIDKFDVFLFDCDGVLWSGSKPIPGVTDTMKLLRSLGKQIIFVSNNSTKSRETYMNKINEHGIAAKLEEIYPSAYSSATYVKKVLKLPADKKVFVLGEAGIEDELDRVGVAHIGGTDPSLRRALASEDVEKIGPDPSVGAVLCGMDMHVTYLKYCMAFQYLQDPNCAFLLTNQDSTFPTNGKFLPGSGAISYPLIFSTGRQPKILGKPYDEMMEAIIANVNFDRKKACFVGDRLNTDIQFAKNSNLGGSLLVLTGVSKEEEILEKDAPVVPDYYVESLAKLAETA
Protein: Guanine nucleotide exchange factor rei-1 (P42171)
Organism: Caenorhabditis elegans
Function: Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows.
Subcellular location: Cytoplasmic granule {ECO:0000269|PubMed:26506309}. Golgi apparatus membrane {ECO:0000269|PubMed:26506309}. Note=Localizes to cytoplasmic granules and to Golgi apparatus membrane in growing oocytes. Co-localizes with rab-11.1 at Golgi apparatus membrane in embryos. {ECO:0000269|PubMed:26506309}.
Interaction partners:
- Ras-related protein rab-11.1
- DNA-directed RNA polymerase III subunit RPC8
- Nucleolar GTP-binding protein 1
- C2H2-type domain-containing protein
Sequence:
MTEGDDQLISIRKQLENLNNATDDINSYEMKLETVKKQFCETQLMFNKEMLGIPKKLAKHISKSRQFFDLKSRESEIRRCVQQAAAQFERQKTSVEMAREQVQILHNSLNNNQELDAEKQYVDVIEQQLELVKEAEGECLKAEKCHASRVRDLLQLEMALRKCLEENGSAIKKSRPYYERKEVLTRTMNSQLELMSILEHEVQERKDSYSDSMRALEQISDQIHQERSSQSSLAPSSDAESDSS
Protein: NAD(P)(+) glycohydrolase toxin Tse6 (EC 3.2.2.5) (Q9I739)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Effector EagT6
- Immune protein Tsi6
- Type VI secretion system spike protein VgrG1a
- Elongation factor Tu
- DNase toxin Tse7
- Type VI secretion system spike protein VgrG1b
- Toxin protein Tse5
- Toxin protein Tse4
- Peptidoglycan amidase Tse1
- Toxin Tse2
Sequence:
MDAQAAARLGDEIAHGFGVAAMVAGAVAGALIGAAVVAATAATGGLAAVILAGSIAAGGLSMFQIVKGLTTIFELPEPTTGVLIRGSFNVYVNSRNAMRAGDDVSATCSGLPLNHPLWPFPVLIAEGSATVYINGKPAARLQSKMVCGAHIKTGSQNTFIGGPTERVAFVLDLEEWLHTGLEALGLAALAGGLLLAAMAGVAALVGVVAIGGLMMGGMALLGDLGDRLGPGYRDLFQGVAGMALLGFGPKLAGRRPAAVTSETAQRRAYLNNKFGRSGNLDHDINYRGNRETAAKFFKSKDIDPADAESYMNGLDFNHPVRVETLAPGKNLWQYQSPGAPQGNWYTLSPRVQPTELGINPMGTNRAANTIEPKVLNSYRTTQKVEVLRSTAAPTDDFWSVKGQSYPAKGGAQQLFSNEKGSFGLLPREGS
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Q16795)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:12611891}.
Interaction partners:
- NADH dehydrogenase flavoprotein 3, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 5
- Cytochrome b-c1 complex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 6
Sequence:
MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPCRQLHHALMPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFASMHRFGPIPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVNI
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8I2F4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKDQIESSLYSQRTKISAEDKDSFSCRKSSPFNKETRKEKSLSVFFSSCSRLSLLGLLCIFLLNFYIYNGNCNVVEGTIGHKRKLSELVDSKSGCLRSGENETNVKSSSSQTDSVLSSNNLTDFYNSYNEFNIKDELDDIFKSIGLTSLHDKYYDLTKQWSDEKIEEIINSLLDIPNKFDVLTIWMQVRGSEKLKMHNMLYGLRLLYKELINKYNIPMESCTHIWLNCYYDITNYHLYIEHENNINFLDLTTKEILTRTDFIDFIKDTKNKFNKLRNELRETVRKDLIDKLTPRHME
Protein: DdrA (Q71TE4)
Organism: Escherichia phage P1 (Bacteriophage P1)
Interaction partners:
Sequence:
MTLSAIELMDLSDKLDALMSKAATASGMELLDISDEIDQIMQQMGYGASGDGSGEEKQPSEHDGVPKLVADFLADKFVDQSTDAFIGTLQDLSQYVGIYIDLDQVKQHTAAWIAANIKEAA
Protein: Large ribosomal subunit protein mL40 (39S ribosomal protein L40, mitochondrial) (L40mt) (MRP-L40) (P83565)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:9857009}.
Interaction partners:
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein uS10m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL32m
- Large ribosomal subunit protein uL13m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL30m
Sequence:
MATAAMLCAARALRPRSWIPGTCQAQVRHTHQRASLLSFWELIPMRAEPLRKKKKVDPRKDQAAKDRLKKRIRKLERASQELVPIEDFITPVRFLDKSRQRPQEEHSFEESERRALLLKRWALYKQQEHEMERDAIRAMLEAQQEALEQLKLESTELYAEAIKRDTSLFPFEKEGPHYTPPVPNYQAPEGRYNDITKVYTQVEFKR
Protein: Crossover suppressor on 3 of Gowen (Crossover suppressor on 3 of gowen, isoform B) (Crossover suppressor on 3 of gowen, isoform C) (FI01435p) (Q9VF37)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Crossover suppressor on 2 of manheim
- Meiotic recombination protein W68
- Protein ORD
- Meiotic recombination protein P22
- RE15841p
- FI21203p1
- Myosin heavy chain, non-muscle
- FI20148p1
- RING finger protein vilya
Sequence:
MTGAKKRSGAPLVDAAHSKAPKPGTVAQEKNSQIPTVWKKDHVKTQLFERSNEKPSKKRTPLVAPRVQQSKIEAQTSQAVEKTQEDQTFAATIDSSTKSLKKSPKNEGELWADIQKLSPHTGIIIHSFIKQYNESLNNLKKKDLVVSKKMRAIAMDSLKKKSENISLKEKLTNMELELTQLKTDLIEQQEKNAENIQKYTEINKKYTHCEQHYDKELEIIKVCVEKKNSELRDAQSRMALQAQELNNMQQTNRELAGACENYKKDLEEAEVAKSMILHELTDLKELHEDLQLQFEDVSAQKEKFEANILQLSSDLNAKMLDCAQLEDRIEQLPIEANKALSKLQRDLEASELQFVDQQRLTDQATRELELVRNEINTFKTLIEEKERRHVSLSDELTQMTERLSELADINESYINELTETKLKHSQEIKDQADAYEIVVQELKESLNKASVDFTQLKSNSEKLHKETLLQVSELQEKLIEMVSHRSNQEELIKRLGNEIQEKTHNFEEELKRQQEQLANQMQMKATEVESENKRNAVEIQKLKSELEERNKAFKAQQDKLEYLISDHDTLKSAIINLQAEKKEIESELSTAKVKFSEELQSQKDNLMKKVSELELEIKRKETELIELEREKNNEMAVLQFKMNRINCLIDQPVTTIKQLKDSKGPTRTESIPTKVQPENTDEFSSTARKRNARRQKITTYSSDFDSGDDIPIVGNSLSGKRAKLCAPIKPQNNIDMFDMLKNSK