wanglab/gogpt-training-data huggingface dataset:
Protein: Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) (P05201)
Organism: Mus musculus (Mouse)
Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Subcellular location: Cytoplasm.
Interaction partners:
- Malate dehydrogenase, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Aspartate aminotransferase, mitochondrial
- Malate dehydrogenase, cytoplasmic
- Alanine aminotransferase 2
- Alanine aminotransferase 1
- L-lactate dehydrogenase B chain
- Cystathionine gamma-lyase
- Tyrosine aminotransferase
- L-lactate dehydrogenase C chain
Sequence:
MAPPSVFAQVPQAPPVLVFKLTADFRDDPDPRKVNLGVGAYRTDESQPWVLPVVRKVEQKIANDNSLNHEYLPILGLAEFRSCASRLVLGDNSLAIRENRVGGVQSLGGTGALRIGADFLGRWYNGTDNKNTPIYVSSPTWENHNAVFSAAGFKDIRPYCYWDAEKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTPEQWKQIAAVMQRRFLFPFFDSAYQGFASGDLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGKESDSVLRVLSQMEKIVRITWSNPPAQGARIVAATLSDPELFKEWKGNVKTMADRILTMRSELRARLEALKTPGTWSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINMCGLTTKNLDYVATSIHEAVTKIQ
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (A0A8I5ZJI2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
Sequence:
MLLRSSGKLNVGTKKEDGESTAPTARPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGTPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRTHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
Protein: cAMP-dependent protein kinase type I regulatory subunit (DRI class I to class IV) (P16905)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit 1
- cAMP-dependent protein kinase catalytic subunit 2
- GH13213p
- Combover, isoform A
- UT01108p)
- cAMP-dependent protein kinase catalytic subunit 3
- FI03282p
- Ribosomal protein S6 kinase
- Protein phosphatase PHLPP-like protein
- cAMP-dependent protein kinase type II regulatory subunit
Sequence:
MSYMMAKTLEEQSLRECEHYIQTHGIQRVLKDCIVQLCVCRPENPVQFLRQYFQKLEREQVKLDASRQVISPDDCEDLSPMPQTAAPPVRRRGGISAEPVTEEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRSEGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKRNITQYNSFVSLSV
Protein: Cysteine synthase, mitochondrial (EC 2.5.1.47) (Beta-substituted Ala synthase 2;2) (ARAth-Bsas2;2) (CSase C) (AtCS-C) (CS-C) (O-acetylserine (thiol)-lyase) (O-acetylserine sulfhydrylase) (OAS-TL C) (Q43725)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a cysteine synthase. Plays a role in the sulfide detoxification in mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Assimilatory sulfite reductase
- Probable cystathionine gamma-synthase 2
- Cystathionine gamma-synthase 1, chloroplastic
- Serine acetyltransferase 3, mitochondrial
- Cystathionine beta-lyase, chloroplastic
- L-cysteine desulfhydrase
- Probable L-cysteine desulfhydrase, chloroplastic
- Methionine gamma-lyase
- Serine acetyltransferase 5
- Phosphoserine aminotransferase 1, chloroplastic
Sequence:
MVAMIMASRFNREAKLASQILSTLLGNRSCYTSMAATSSSALLLNPLTSSSSSSTLRRFRCSPEISSLSFSSASDFSLAMKRQSRSFADGSERDPSVVCEAVKRETGPDGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVVFPSFGERYLSTPLFQSIREEVEKMQPEV
Protein: Glutamate receptor 3.5 (F4ITQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGFFVMIRDVSMGFMLLCISALWVLPIQGAGRESFSRNSSSSSLPSSVNVGALFTYDSFIGRAAKLAFVAAIEDINADQSILRGTKLNIVFQDTNCSGFVGTMGALQLMENKVVAAIGPQSSGIGHIISHVANELHVPFLSFAATDPTLSSLQYPYFLRTTQNDYFQMNAITDFVSYFRWREVVAIFVDDEYGRNGISVLGDALAKKRAKISYKAAFPPGADNSSISDLLASVNLMESRIFVVHVNPDSGLNIFSVAKSLGMMGSGYVWITTDWLLTALDSMEPLDPRALDLLQGVVAFRHYTPESDNKRQFKGRWKNLRFKESLKSDDGFNSYALYAYDSVWLVARALDVFFSQGNTVTFSNDPSLRNTNDSGIKLSKLHIFNEGERFLQVILEMNYTGLTGQIEFNSEKNRINPAYDILNIKSTGPLRVGYWSNHTGFSVAPPETLYSKPSNTSAKDQRLNEIIWPGEVIKPPRGWVFPENGKPLKIGVPNRVSYKNYASKDKNPLGVKGFCIDIFEAAIQLLPYPVPRTYILYGDGKKNPSYDNLISEVAANIFDVAVGDVTIITNRTKFVDFTQPFIESGLVVVAPVKGAKSSPWSFLKPFTIEMWAVTGALFLFVGAVIWILEHRFNEEFRGPPRRQIITVFWFSFSTMFFSHSMHTITFKIIRKHQREETLGSFLLLPRSQGVLFFFLC
Protein: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) (Q9VNI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|HAMAP-Rule:MF_03023}. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. {ECO:0000256|HAMAP-Rule:MF_03023}.
Interaction partners:
Sequence:
MFNTSAQNWFGMGQTAVDPSGGVAQLLNNNSSLYNQQQQQAAAAQHSFMRQRSLTSSNPVLGRSNALATRPQSPPNVQVEYEVAVPFVPTYRHTPYHSLWDLHQCSSTPPTSLSHMARMMDSLILDSLSPFGFTKITATSRPSRNASLKKSSEGGHSSTAERHRPVNNLGSNAPGGLGIGGSVPLRSKQRLPTQEVAPQPRASQTAQMPFPSQQQDNRWVSSLRRRDPELQPTLPSINSNANSSSLSQSHHGSAGNVGLAGAGAPTPAASMGTMRLGRPARASAMTAALRKSRSVERLRARKLSTNTQLNLKHKPVKKNSLDENSNSDDQDATTSLEDNSHAQSLATSHNTPKCSPKTKAKHFSPLGYEVHLVDTLEKDILQRHPCIKWTDVAGLNEAKTILQEAVVLPVIMPEFFKGIRRPWRGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDALCASRGSDSEHEASRRFKAELLIQMDGLNASMQEEKVIMVLAATNHPWDIDEAFRRRFEKRIYIPLPNEGTRSALLKLCLKDVCLSPSLNTGIIGDELQGYSGSDISNVCRDASMMAMRRLISGRTPDQIKQIRREEVDQPITLQDFQDARLRTKKSVSADDVARFEKWMEEYGSC
Protein: Testis-expressed basic protein 1 (Uncharacterized protein C6orf10) (Q5SRN2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MTVLEITLAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQTELILLLMCFILALSRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPIIISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE
Protein: Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Lymphocyte activation antigen CD30) (CD antigen CD30) (P97525)
Organism: Rattus norvegicus (Rat)
Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts (By similarity). Regulates gene expression through activation of NF-kappa-B.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P28908}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 8
- CD27 antigen
- Tumor necrosis factor ligand superfamily member 4
- Tumor necrosis factor receptor superfamily member 4
- IgG receptor FcRn large subunit p51
- TNF receptor-associated factor
- CD33 molecule
- TNF receptor-associated factor.
- CD70 antigen
- Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a.
Sequence:
MSILLKAAGLLFLGMLQAFPKDRPLDTTCTGDLSYYPGEAARNCCYQCPSGLSPTQPCPQGPATARSSVILTTTNEDRKCTACVTCLPGLVEKAPCSGNSPRICECQPGMYCSTPAVNSCARCSEKTVVKFPDTAEKNTICDLPSPGSGPNGSNPDDCKTLTSHTTPQAIPTLESPANDSVRSLLPKQVTDFVNEGATKLVKVPESSSSKASMPSPDPGNAEMNMTLKLPPPGTVPDISTSENSMEPASTASTLSLLVDARTSSRMQPTSPLSTGTPFLDPGSMLFWVAMVVLLVGSASFLLCYWKACRRRFQRKFHLNYLQQTFQPKMEQVDSCPTEKLTQLQRSGSVTDSSAGHTLSPLSPPAVETGASVGTACLETLPLLDDSITGNSFAPREPPEPRVSTEHTNNRIEKIYIMKADTVIVGSVKTEVPEGRAPVGSTESELEAELEVDHTPHYPEQETEPPLGSCTEVMFSVEEGGKEDHEPTTVSEK
Protein: Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)] (W5PLZ6)
Organism: Ovis aries (Sheep)
Function: Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (By similarity). The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P09848}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P09848}. Note=Brush border. {ECO:0000250|UniProtKB:P09849}.
Interaction partners:
- Beta-galactosidase
- Aldose 1-epimerase
- Alpha-lactalbumin
- Alpha-galactosidase
- Glucose-6-phosphatase
- Hexokinase-2
- hexokinase
- Aldo-keto reductase family 1 member B1
- Hexokinase-3
- Phosphotransferase
Sequence:
MELAWHLVLIVLLSFSCWGLDWDSDKNFISAAGPLTNNLLHNLRDPLGNQDPPFVAEDEEIYVCRQPLPAFLPEYFRSVRASMITHYKVFLPWAQLLPEGISENPDKGTVLCYRQLLEALKTAQLQPLVVLHHQTLPASTLQRTEAFADLFAAYASFAFRSFGDLVEIWFTFSDLERVITKLPHQESRSSRLQILTDAHRKAYEIYQEKYAAQGGKLSVVLQAEMVSKLLLEPSTSVLVKDAVDFVSLDLSYECHNEADLPQKLSELQTIEPKVKVFIFSLKLQNCLSTGNDIAQLLFGLLKAINEDQVLVVGFDISTFLSCPSSSKKSWACSLSDSLTLQTALQLGPDTAAYAWPPCSAYQRVWEAFANQSKAERDAFLQDVFPEGFLWGVSTGAFNVEGGWAEDGRGPSIWDRVGHQNTIKGQATPEVASDSYHKVDTDVALLRGLQAQVYKFSISWSRIFPTGQGHNPNPRGVAYYNKLIDSLLDSHIEPMATLFHWDLPQALQDRGGWQSEDVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHAPGISDPGVASFKKVAHMVLKAHAKAWHLYNSHHRPQQQGRVGIVLNSDWAEPLSPERPEDLRAAERFLHFMLGWFAHPIFVDGDYPAALRAQIQQMNKQCPSPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLVSTAQGDTCIPSYDTIGGFSQHIDPMWPQTASSWIRVVPWGIRRLLKFVSLEYTKGKVPIYLAGNGMPIGESEDLIDDSLRVDYFNQYINEVLKAIKEDSVAVQSYVARSFIDGFEGPSGYSQRFGLYHVNFNDSSRPRTARKSAYFFTSMIEKNGFLNKVVKRQSSPGIANIPRKIRAFTFPSEVPSKAKVVWEKFSNQPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDVACDSYNHLDADLNMLQALKVKAYRFSISWSRIFPTGRNTSVNTHGVDYYNKLINGLVENNISPMVTLFHWDLPQALQDIGGWENPSLIDLFNSYADFCFQTFGDRVKFWMTFNEPTYQAWLGYGSGEFPPNVNDPGWGPYRIGHTIIKAHARVYHTYDEKYRQEQKGVISLSLSSHWAEPQSLVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDAMKWKVGNRSELQHLATSRLPSFTEEEKRYIAATADVFCLNTYSSRIVQHTTPRLNPPSYTSDQELLEWEDTSWPATAMNRAAAWGTRRLLNWIKEEYGDIPVYITENGVGLTDPELEDTDRIFYHKTYINEALKAYRLDGVNLRGYAAWSLMDNFEWLNGYTVKFGLYHVDFNDVNRSRTARASARYYTEVITNNGMPLSKEDEFLYGQFPKDFIWSAATAAYQIEGAWRADGKGLSIWDTFSHTPLKVENNDTGDVACDSYHKIAEDLVALQTLGVTHYRLSISWTRILPDGTNKYVNEAGLNYYVRLIDTLLAANIQPQVTIYHWDLPQALQDVGGWENETIVQRFKEYAEVLFQRLGDKVKFWITLNEPYVVANQGYGYGTAAPGISFRPGTAPYIVGHNLIKAHAEVWHLYNDVYRARQGGIISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYPEVMKTRIRDRSLAEGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYASWISSFDADRGVASITDRSWPDSGSFWLKMTPFGFRRILNWLKEEYNNPPIYVTENGVSHRGEANLNDTSRIYYLRSYINEALKALQDKVDLRGYTVWTLMDNFEWATGFSDKFGLHFVNYTDPALPRIPRESAKVYASIIRCRGFPDPAAGPHACLQQEDAEPTASPASPVSQKIQFLGLRLSTTEAQTALNVLFAFMLLGVCGVAFLSYKYFKHSKQKHTQPGEHELSHRSSF
Protein: Uncharacterized protein (Q581X9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine/threonine-protein phosphatase
- Kinesin, putative
Sequence:
MADSNAVVEHREESDVNIQLEQRRSQVRGLEIQLTRKEAELRRAKEEQALLKELHAVNEVTLRKKQQKESDGAGSRLKIPRESLDEILRLEGEIKCANRRTVELQNEASTTSVQLNDVEKGIESICNRTALVKQVTGWISSGSQSSSVVGVSSEWIMRKKVLTELQDEQNAIKALTALLDKQAEFYTKRLEEQRTKDEEFAEAQRVLREKTVQYENLLGELKSFERLTKKKERLLDTASGKVTDDYKTVKMIEGDKKVLYANLSKLQEANVRNSKSILSLEMRLRQLETKLEAVNLFLQQVFADVEEEDEHIENIPEGATEVPLEQFEELCRELELSRATLLHREEQLNAGDAKVEQLERKTTILENAIASHAVSAQLQVKGKEREFETLMSHVDYMKAEFDEEYKRLTKENAALVSKLGK
Protein: Protocadherin 15b (Protocadherin-15b precursor) (Q5ICW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MKMRQRSWLYKWLGIGIGVLLLTAASYSQDSEDWQYEECKLSRTGPPATIVAIDEQSPNGTLLVENMQINGRAEDPDRTISLSLRDNNDYWVILDPVKQRLYLNSTGRVLDRDPPSYIQSIVVQVQCTNELVGTVILHEVRIVVRDRNDNAPRFQQPRYYVAVNELTPVGTTIFSGFTGNNGAVDIDDGPNGQIEYTIQYNPRDPTTNRTFDIPLTLSGSVVLRERLNYEEITRYLVIIQANDRAPNPKDRLTATTTLTVDVLDGDDLGPMFLPCSLVDNTRDCKPLTYRASILELTDPSRVNPVNVTPPIQAVDQDRNIQPPSDRPGILYSILIGKPETYGEFFWMNRSTAELQLLKAISREKYQHFDLVIKAEQDNGHPLPAFANLHIEVLDENNQAPYFQVATYHGFISESAPLGTTISSSANLSTPLAIIVLDNDIEETKDPMVRISLDNYNGIFAVTAGGIVRYLTLLRPVDHEEQPTYAFTMIASDGVQESAPVTINITVIDANDNTPTFPNVSYGVSVYTDMQPGDPVLQLTALDADDGPNGLVSYKILAGDQGHFTINDCTGVITVLPSVNLTVGRSYALTVRATDNGPTAQRRSSITTVYIEVLPPNNQSPPRFHQLVYSLEISEAMRTGATLLNIQATDREKDPVTYSIQKGDPNNVFEVSQTSGLLLLAKTLDREITDXYTLTVTASDGKPDGTSTTTVNIAVTDVNDNDPEFDPLLPLNLTVQEEEANAFVGQVKATDLDLGINGQVRYRLVSYPDLFRISPNGSIFTAMPLDREERAQYDLIVQASDGAKDPRRTTITLSITVLDVDDNSPVFSPPAYHATLPENSPVGTVILNISALDPDLDANVTYRIRTKEARELFAVNSLTGELKVLRSLDFEKLLPNATTQTFVVEALDGGSGKMPPGLASVTVTVLDMNDFPPVFSQTLYRGMVAPNAVKGTIVTAVHAEDLDPPGTAASRVHYKADLEQFPYSTSIFDVEENSGNIFTRVNLNEEPNTKFSLAVIAYDDGEPMKFNKSLVEITVLQXSIIPVFTQEEYRFAPVSENAPVGTVAGVILAAAINQTIVYSIIEGNEGGEFVVNNNTGVISTAKPLDYESNSSYVLRVEADSMRVVSSNLRAPAKSNTAKVFIDVQDENDHPPVFTKPFYLGGVAEDAKTFTSVLQVQALDKDTGNYSAMLYRLIIPPTTDGKDGFVIEPFTGVIKTAIMYRNMRRSYFKFDVVATDNYGEGLSSSAQVVVSVVNQLDMQVVVSNVPPTVVEQNKDRLIGILERYVQDQIPGAKVVMESIGARRFGDGYEQEDYTKSDLMVYAIDPLTNRALSRQELFKFLDGKLLDINKEFQPYLGRGGRILEIRTPDVVESVTRAVHSVGYTEGALLALAVIIILCCIPAILIVIITYRQFKERQAECAKTARIQMALPTGKSGGAATNNLYEELGDSTIPKTKRCVLKDGDRQRLISSFASRAITAHKLSTANGILLNNFPKSESNITFLSDDNPLTTTNPLYRDDVTLGSPEHQNRSYLLDMYSPSMRGLSKSIMGFPNSGSGHSWTLPSRLHKWDESQRSRRVVMDPVQWELQLLKASLKDSKEMIDGFDGLGDEDPEPKLTVKEQARQFEQQALQDVKLRQGQDSRGSLSSEIILSVFETPHNSRPPAIIITQSDSTPPPSHKPTPPVLRKYTRLSSYPDLESYEVNVEIIPDPPDVPAPQPPPPPPPPSSPPPPPPPSSPPPLPPSSSPPPLPPSSSPPLVPPSPSVPPHPAPPPPPPLPPPLSPSFSRPIPPSPFVLPPLPSVTSLRPVSLRPAPPPLPSEPEPPKRELKGILKNLQNIADIEKSVANMYSQIDKKQRPLVINPKPQVSVEPEAGVTEAEPAQEGPPSEPNPSMNSVVEELEKRFPSQSTVL
Protein: Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) (Q8NB91)
Organism: Homo sapiens (Human)
Function: DNA repair protein required for FANCD2 ubiquitination.
Subcellular location: Nucleus {ECO:0000269|PubMed:15502827}.
Interaction partners:
- Fanconi anemia group F protein
- FA core complex associated protein 20
- Centromere protein S
- Fanconi anemia group E protein
- Fanconi anemia group I protein
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group C protein
- Fanconi anemia group G protein
- Fanconi anemia group M protein
- Fanconi anemia core complex-associated protein 100
Sequence:
MTSKQAMSSNEQERLLCYNGEVLVFQLSKGNFADKEPTKTPILHVRRMVFDRGTKVFVQKSTGFFTIKEENSHLKIMCCNCVSDFRTGINLPYIVIEKNKKNNVFEYFLLILHSTNKFEMRLSFKLGYEMKDGLRVLNGPLILWRHVKAFFFISSQTGKVVSVSGNFSSIQWAGEIENLGMVLLGLKECCLSEEECTQEPSKSDYAIWNTKFCVYSLESQEVLSDIYIIPPAYSSVVTYVHICATEIIKNQLRISLIALTRKNQLISFQNGTPKNVCQLPFGDPCAVQLMDSGGGNLFFVVSFISNNACAVWKESFQVAAKWEKLSLVLIDDFIGSGTEQVLLLFKDSLNSDCLTSFKITDLGKINYSSEPSDCNEDDLFEDKQENRYLVVPPLETGLKVCFSSFRELRQHLLLKEKIISKSYKALINLVQGKDDNTSSAEEKECLVPLCGEEENSVHILDEKLSDNFQDSEQLVEKIWYRVIDDSLVVGVKTTSSLKLSLNDVTLSLLMDQAHDSRFRLLKCQNRVIKLSTNPFPAPYLMPCEIGLEAKRVTLTPDSKKEESFVCEHPSKKECVQIITAVTSLSPLLTFSKFCCTVLLQIMERESGNCPKDRYVVCGRVFLSLEDLSTGKYLLTFPKKKPIEHMEDLFALLAAFHKSCFQITSPGYALNSMKVWLLEHMKCEIIKEFPEVYFCERPGSFYGTLFTWKQRTPFEGILIIYSRNQTVMFQCLHNLIRILPINCFLKNLKSGSENFLIDNMAFTLEKELVTLSSLSSAIAKHESNFMQRCEVSKGKSSVVAAALSDRRENIHPYRKELQREKKKMLQTNLKVSGALYREITLKVAEVQLKSDFAAQKLSNL
Protein: Nuclear pore complex protein (A1YK56)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|RuleBase:RU365072}. Nucleus membrane {ECO:0000256|RuleBase:RU365072}.
Interaction partners:
Sequence:
MADSPFPRSSRSGLLRTTLNSSMAPQNLSHSLLILEKSNAEQNERSLMEDTGDNLDRGKSRMDVLFPQFFDVLQAQGNGQEAFEVIQSLTQVCLGVCVEPLELEIDHGXGGEQGARQRESMXXXLXQEINTWRLLHALFYDRILLQTDRQADDEMQDGPTLGGSEKEVIQQLYALNATLREYQVVVDWLEACYDRGEQQNPLHAHDRMMAWENTLFQLENLQGAAFGKGHKIVTRLDPDAPVREKRPLHALDEEDNLRLSRAIFELIRAGRVDDGLKLCKHFGQTWRAAILEGWRLHEDPNFEQNVSVLHEKLPIEGNPRRDIWKRCAWMLADSKNYDEYSRATAGVFSGHLGSLKTLLHSNWHDLLWAHLKVQIDIRVESEIRGCCLKNYQPMPDDYWNGRMTMEQIFEELNVAKDASVRDFAQSQLGIIQRHLILDTCGELIQHMVRWVEKDTSQQSPHQLRFMAHIVLFLRQIGRVEQERQAEKIVAAYVEALIARGEPQLIAYYTASLSNPLQVQLYSRFLEQVEQKRPRELAVDAALQAGLDVEQITRVTVQNIRLAHQPLGEFGEPQSGEISAIDQRKISALEWLIHLPEQRGELLWQANAMIRTYLASSKVECMRQTFRMVPADIVQQLVSLYGSVDNIPPREECCLKEYLCYKAYLSGVDSFVEWNRLQQNRPKKPQTSHAASSQDNFTERMASERKEQAHRSEVVRWEHKVKEQAKQTIELLYNVLMFPDKGWLVDPFIAKLPENAVQLNWDHRLLQMEKLRSICIPEIALFLNEVMFKSGDFAGCVRLADEISSENRQLYKVYTKHKLAELLAKIADASLELLNSKLDPWGYPITT
Protein: Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) (O70535)
Organism: Rattus norvegicus (Rat)
Function: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Leukemia inhibitory factor
- Ciliary neurotrophic factor receptor subunit alpha
- Ciliary neurotrophic factor
- Oncostatin-M
- Cardiotrophin-1
- Interleukin-6 receptor subunit beta
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Cardiotrophin-like cytokine factor 1
- Cardiotrophin-2
Sequence:
MGAFSWWRQPSWMADNKRGRMTPSLPWLLSALTLLHLMMHVNGLKRGVQQDLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKDRPHSCHRLETTNVKIPALSPGDHEVTINYQNGFQSKFTLNEKDVSLVPDTPEILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELPLQCATHSVSIRWHIDYPRFSGYKEWSEWSPLKNISWTRNTETNVFPQDKVVLAGSNMTICCISTTKVLSGQIGNTFRPLIHLYGETVAINILNIPVSENSGSNVIFSTVDDVYGTVVFAGYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRFEELANETYWLTLKMAPDQEIHNFTLTARNPLGQTESAIVINATERVALHVPISLKVKDVNSTVVTLSWYLPGNFTKINLVCQIEICKANSKKEVRNVTMRGAEDSTYHVAVDKLNPYTIYTFRVRCSSETFWKWSKWSNEKRYLTTEATPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSSEETQSLSEILDPQHKAEIKVNKNDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQAVGIGNRIFLSWQHNPNMTCDYVIKWCNSSWSEPCLLDWIKVPSNSTGTVIESDQFQPGVRYNFYLYGCTNQGYQLLRSTIGYIEELAPIVAPNFTVEDTSADSILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLETSHSDIKLKNITDISQKTLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNHVEVLESRSIPPKIEDTEITSPVSERPGESSETDPENQAAVSYCPPIIEEEITNPAADEAGGASQVVYIDVQSMYQPQAKAEDEQDTDPVMVAGYKPQMRLPINPTAEDTTAEDEADKTAGYRPQANVNTWNLVSPDSPRSTDSNSEVVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
Protein: Fructokinase-like 2, chloroplastic (AtFLN2) (Plastid-encoded RNA polymerase-associated protein 13) (PEP-associated protein 13) (pfkB-type carbohydrate kinase family protein 1) (F4I0K2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription. Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:20511297}.
Interaction partners:
- Thioredoxin-like protein CITRX, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 14
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 10
- Protein PLASTID REDOX INSENSITIVE 2
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 7
- PLASTID TRANSCRIPTIONALLY ACTIVE protein 6, chloroplastic
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic
- Pentatricopeptide repeat-containing protein At1g74850, chloroplastic
- Plastid transcriptionally active 3
Sequence:
MASLSFTQFLSFPRCNADVPCLLQSHGFVKFRGERWNGKQSFSMAAGRRKLSESAPLEEEGNDGNGAVVGKKPSKSVKRTTKKKVVVKDEPLEEISEFLVDNDDVLDKESIVSALKPKKTRTRKKAAAASSDVEEVKTEKKVRRKRTVKKDKDVEDDLATIMDAEVSDVEEALAVESTDTESEEEEIDLSKHEGEDISHTYGWPPLVCCFGSAQHAFVPSGRPANRLLDYELHERMRDAKWAPEKYIRAPGGCAGGVAIALASLGGKVAFMGKLGADDYGQAMLYYLNVCKVQTRSVKIDGKRVTACSTMKISKRGRLKSTCIKPCAEDSLSKSEINVDVLKEAKMFYFSTHSLLDKKMMSTTIQAIKISKQLGNVIFYDLNLPLPLWHSSEETKSFIQEVWNLADVIEITKQELEFLCGIEPTEEFDTENNDISKFVHYPPETVEQLWHENLKVLFVTNGTSKIHYYTKEHNGAVSGMEDVPITPFTRDMSASGDGIVAGLIRMLTVQPDLMNNKGYLERTARYAIECGIIDQWLLAQTRGYPPKDDMEEEEDDEEEDEVESDPNGIRSITEKEYRTSKPYDEPDGPYVMKPVEEREYKKLELVGSMFEDGSL
Protein: Tyrosine-protein kinase transmembrane receptor ROR2 (mROR2) (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (Q9Z138)
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19785987}; Single-pass type I membrane protein {ECO:0000269|PubMed:19785987}.
Interaction partners:
- Protein Wnt-5a
- Inactive tyrosine-protein kinase transmembrane receptor ROR1
- Vang-like protein 2
- Frizzled-1
- Frizzled-5
- Frizzled-2
- Protein Wnt-11
- Frizzled-4
- Frizzled-9
- Frizzled-7
Sequence:
MARGWVRPSRVPLCARAVWTAAALLLWTPWTAGEVEDSEAIDTLGQPDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQVEGPWCFTQNKNVRVELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDAQNIAEDVAQSPVQEAEEEEEGSVPETELLGDNDTLQVTEAAHVQLEA
Protein: Cdc42-interacting protein 4, isoform I (M9NF07)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLALLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKQRQIIEACITMKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSSSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA