wanglab/gogpt-training-data huggingface dataset:
Protein: Complement decay-accelerating factor, GPI-anchored (DAF-GPI) (CD antigen CD55) (Q61475)
Organism: Mus musculus (Mouse)
Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Adhesion G protein-coupled receptor E5
- Complement C4-B
- CD59B glycoprotein
- CD59A glycoprotein
- Intercellular adhesion molecule 1
- Complement decay-accelerating factor transmembrane isoform
- Complement factor B
- Complement C3
- Complement C2
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Sequence:
MIRGRAPRTRPSPPPPLLPLLSLSLLLLSPTVRGDCGPPPDIPNARPILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCVAPERLSFASLKKEYLNMNFFPVGTIVEYECRPGFRKQPPLPGKATCLEDLVWSPVAQFCKKKSCPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGVSSTFCSVTGNTVDWDDEFPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSKSDVGQWSSPPPRCIEKSKVPTKKPTINVPSTGTPSTPQKPTTESVPNPGDQPTPQKPSTVKVSATQHVPVTKTTVRHPIRTSTDKGEPNTGGDRYIYGHTCLITLTVLHVMLSLIGYLT
Protein: Nuclear prelamin A recognition factor (E7EP87)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKCEHCTRKECSKKTKTDDQENVSADAPSPAQENGEKGEFHKLADAKIFLSDCLACDSCMTAEEGVQLSQQNAKDFFRVLNLNKKCDTSKHKVLVVSVCPQSLPYFAAKFNLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRYRQHSEEERTLPMLTSACPGWVRYAERVLGRPITAHLCTAKSPQQVMGSLVKDYFARQQVQEEMGSAFPVLPGGSTGWGALQMFGRTTPSPEGGSRQTWMECWCSNLSPEKIFHVIVAPCYDKKLEALQESLPPALHGSRGADCVLTSGEIAQIMEQGDLSVRDAAVDTLFGDLKEDKVTRHDGASSDGHLAHIFRHAAKELFNEDVEEVTYRALRNKDFQEVTLEKNGEVVLRFAAAYGFRNIQNMILKLKKGKFPFHFVEVLACAGGCLNGRGQAQTPDGHADKALLRQMEGIYADIPVRRPESSAHVQELYQEWLEGINSPKAREVLHTTYQSQERGTHSLDIKW
Protein: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (EC 3.2.1.96) (Q9VX51)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- GEO08825p1
- LD46305p
- Uncharacterized protein, isoform A
- Peptide-N
Sequence:
MDSLESKELASISKVMENNDKASENDKITGITTEEEEEVVPVKKKRTEEGGGELKEVACEKETVQREKCQDKNTCRCSQLEAEPIKDNRQLLEFRVRSRNIDWREYVLPLDTSVRTTPVYLDRQADFVGSTRRQVTEDNRRELLVCHDMMGNYLEDRHFHSSQKYDDYRFVHWSAVDYFCYFSHDYVTIPPCGWLNAAHRHGVPVVGTFIVEATARLDEFLASEESVESTVEALTRLCEHFGFEGWLVNVEVTVPLAKMPRLYRFVRQLTAATESRVPHGRVFWYDSVTDDGQLRWQNELNSRNAKFFRHSHGTLINYAWDEGHLERSAQQVRREQSPRHRVFMGLDVFGRSRKGGFHSWETMELIAKNGFSAGIFAPGWTFETLNRFGYNIKNPRGDDQVNASFLARNEAWWSRIWPTLATHPYTSLPFFTDFCVGSGRAKFERGWRILGEDSPFFNLSRQSLQPSVPLGRNAMHHFDEAYSGGCSLLVTNYERAFRLFVTDFELDRGVLLLRYVFKIDGDAVGTMFDLLVRVTPLRRNDQDLHLFCGDYEGSIVAPQRCYLSPHESDLPSGLFRLHHDSSSLAAGWQMRDYLVKFDGPVRVQDIGVKYQRPSESSTDAKLGFVYVDGLTLEDLKDTWTDIPVYSKHMWNEQRA
Protein: 30S Ribosomal protein S17, putative (Q38DP8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 50S ribosomal protein L2, putative
- Large ribosomal subunit protein uL3m
- Ribosomal protein L11, putative
- 50S ribosomal protein L13, putative
- 40S ribosomal protein S18, putative
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- 40S ribosomal protein S15a, putative
- 50S ribosomal protein L17, putative
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein mL46
Sequence:
MLRRSLLAFPWWNFQTEHRQRCVLMYGGARTKNTHNANHRVFIKKYKRNAFPNRTRHHWAVSMTGVLSQRPRRMPWPYDLTSLIFNQPRQGSDKIGYVVGTSMLKTAVVATNHMVYYPKFNQRVSRTKRFFAHDEDLVCVEGDLVHIKQCRKISKYKHYYVFSILEPNVEGRERLKLGLKAVPPPLFGYPVSRRIVKLNLTSTEGTQEKLAAAIQEHVQDAYRFSGPTPDQPRNRLADPVTFEDANNMIAPNAPAAAALDASDSPPLLDRGEYTEVEQDTRNKKGDDYWMNLQPKEKYDFKSFKKSP
Protein: Small ribosomal subunit protein eS24y (40S ribosomal protein S24-2) (Q8LC83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS1z
- Large ribosomal subunit protein eL32z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein uS17y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS13z/uS13y/uS13x
- Small ribosomal subunit protein eS19z
Sequence:
MAEKAVTIRTRNFMTNRLLARKQFVIDVLHPGRANVSKAELKEKLARMYEVKDPNAIFCFKFRTHFGGGKSSGYGLIYDTVENAKKFEPKYRLIRNGLDTKIEKSRKQIKERKNRAKKIRGVKKTKAGDTKKK
Protein: Suppressor of hydroxyurea sensitivity protein 2 (P38957)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Chromosome segregation in meiosis protein 2
- Suppressor of HU sensitivity involved in recombination protein 1
- Platinum sensitivity protein 3
- DNA repair protein RAD55
- DNA repair protein RAD2
- ATP-dependent helicase SGS1
- DNA repair protein RAD4
- General transcription and DNA repair factor IIH subunit TFB1
- DNA repair protein RAD16
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
Sequence:
MSKDVIEYSKLFAKLVNTNDDTKLDDTIASFLYYMFPRELFIRAISLLESSDMFIYILDRVHNKEGNEHTSLIDVLVDEFYKGSSNSLLEYRLIVKDTNDGAPPILVDIAHWFCSCEEFCKYFHEALEKTDEKEELHDVLINEVDDHLQFSDDRFAQLDPHSLSKQWYFKFDKVCCSHLLAFSILLRSSINVLKFFTVNSNKVFVIAIDNIDEWLNLHINIVE
Protein: Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) (Q92753)
Organism: Homo sapiens (Human)
Function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:27352968}.
Interaction partners:
- Nuclear receptor ROR-alpha
- Period circadian protein homolog 3
- Nuclear receptor ROR-gamma
- Basic helix-loop-helix ARNT-like protein 1
- Neuronal PAS domain-containing protein 2
- Circadian locomoter output cycles protein kaput
- Cryptochrome-1
- Period circadian protein homolog 2
- Nuclear factor interleukin-3-regulated protein
- Class E basic helix-loop-helix protein 40
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
Protein: Protein phosphatase 2C 29 (AtPP2C29) (EC 3.1.3.16) (Protein POLTERGEIST-LIKE 1) (Protein phosphatase 2C PLL1) (PP2C PLL1) (O82302)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Receptor protein kinase CLAVATA1
- Protein phosphatase 2C 70
- AT-hook motif nuclear-localized protein 8
- Receptor-like protein CLAVATA2
- Protein WUSCHEL
- Protein CLAVATA 3
- Remorin family protein
- WUSCHEL-related homeobox 5
- AT5g65480/K19O4_1
- LRR receptor-like serine/threonine-protein kinase RPK2
Sequence:
MGSGFSSLLPCFNQGHRNRRRHSSAANPSHSDLIDSFREPLDETLGHSYCYVPSSSNRFISPFPSDRFVSPTASFRLSPPHEPGRIRGSGSSEQLHTGFRAISGASVSANTSNSKTVLQLEDIYDDATESSFGGGVRRSVVNANGFEGTSSFSALPLQPGPDRSGLFMSGPIERGATSGPLDPPAGEISRSNSAGVHFSAPLGGVYSKKRRKKKKKSLSWHPIFGGEKKQRPWVLPVSNFVVGAKKENIVRPDVEAMAASSGENDLQWALGKAGEDRVQLAVFEKQGWLFAGIYDGFNGPDAPEFLMANLYRAVHSELQGLFWELEEEDDNPTDISTRELEQQGEFEDHVNEMASSSCPATEKEEEEMGKRLTSSLEVVEVKERKRLWELLAEAQAEDALDLSGSDRFAFSVDDAIGAGNAVSVGSKRWLLLSKLKQGLSKQGISGRKLFPWKSGVEENETEEVDNVGVEEGVDKRRKRRKAGTVDHELVLKAMSNGLEATEQAFLEMTDKVLETNPELALMGSCLLVALMRDDDVYIMNIGDSRALVAQYQVEETGESVETAERVEERRNDLDRDDGNKEPLVVDSSDSTVNNEAPLPQTKLVALQLTTDHSTSIEDEVTRIKNEHPDDNHCIVNDRVKGRLKVTRAFGAGFLKQPKLNDALLEMFRNEYIGTDPYISCTPSLRHYRLTENDQFMVLSSDGLYQYLSNVEVVSLAMEKFPDGDPAQHVIQELLVRAAKKAGMDFHELLDIPQGDRRKYHDDCTVLVIALGGSRIWKSSGKYL
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LIK1)
Organism: Oryza rhizomatis
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: L-type lectin-domain containing receptor kinase S.7 (OsLecRK-S.7) (EC 2.7.11.1) (Protein DEFECTIVE IN APERTURE FORMATION 1) (OsDAF1) (A0A0P0VIP0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Legume-lectin receptor-like kinase required for normal pollen development and male fertility. Regulates pollen exine assembly and aperture development. Plays a critical role in annulus formation, and may participate in the formation of the fibrillar-granular layer underneath the operculum. May function by regulating the expression of genes involved in pollen exine development. Kinase activity is required for its function in pollen development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:31833176, ECO:0000269|PubMed:32284546}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:32284546}. Note=During meiosis, localizes diffusely in the cytosol and plasma membrane of microspore mother cells (MMCs). During tetrad development, localizes at the corners. At late tetrad stage, accumulates to the four corners of the tetrad, assembled into ring-like structures marking future aperture sites. When microspores are released from tetrads and preliminary aperture structures has formed, remains in a distinctly ring-shaped distribution beneath the aperture in the plasma membrane between the annulus and operculum. {ECO:0000269|PubMed:32284546}.
Interaction partners:
Sequence:
MPPRCRRLPLLFILLLAVRPLSAAAASSIAAAPASSYRRISWASNLTLLGSASLLPGAAGVALTTPSRDGVGAGRALFSEPVRLLLPQDAAASASASRAATPASFSTRFTFRITPSPTYGDGLAFLLTSSRTFLGASNGFLGLFPSSSASDEGELRDVSTVAVEIDTHLDVALHDPDGNHVALDAGSIFSVASAQPGVDLKAGVPITAWVEYRAPRRRLNVWLSYSPSRRPEKPALSADVDLSGLLRTYMYAGFSASNGNGAALHVVERWTFRTFGFPNSSYAPPPTKYIGPMPPNNQPLPPPPSPSPSPPPPSPPPPPHPNHRRRHLFYKVLGGVLGGMVLLGLVVVGSAVLLGRSVRRKNQEHAVASEDMGEATLSMEVARAATKGFDSGNVIGVGGSGATVYEGVLPSGSRVAVKRFQAIGSCTKAFDSELKAMLNCPHHPNLVPLAGWCRSKDELVLVYEFMPNGNLDSALHTLGGATLPWEARFRAVYGVASALAYLHDECENRIIHRDVKSSNVMLDAEFNARLGDFGLARTVSHGGLPLTTQPAGTLGYLAPEYVHTGVATERSDVYSFGVLALEVATGRRPAERGISVVNWVWTLWGRRRLVDAADRRLQGRFVADEMRRVLLVGLCCVHPDCRKRPGMRRVVSMLDGTAPLILVPDKMPPVLLQPVPNASSMNSADTANTAFFSCR
Protein: RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (Q95QG8)
Organism: Caenorhabditis elegans
Function: During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1. Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage. May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB7
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
- RNA polymerase Rpb4/RPC9 core domain-containing protein
- Cyclin-dependent kinase 12
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB2
- General transcription factor IIF subunit 2
Sequence:
MDIKFEGNDAECTAGLKKASEGSFVLKDHVLIEFKINGKVAGKIKTPCEGVVTFGKGLKPGIVLNKGQVIATVSECTHAIVIKDMCATCGKDLREKGGRAGQRKEQSTANVSMIHHVPELIVSDTLAKEIGSADENNLITNRKLVLLVDLDQTIIHTSDKPMTVDTENHKDITKYNLHSRVYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILSRDELFSAQHKTNNLKALFPCGDNLVVIIDDRSDVWMYSEALIQIKPYRFFKEVGDINAPKNSKEQMPVQIEDDAHEDKVLEEIERVLTNIHDKYYEKHDLRGSEEVLLDVKEVIKEERHKVLDGCVIVFSGIVPMGEKLERTDIYRLCTQFGAVIVPDVTDDVTHVVGARYGTQKVYQANRLNKFVVTVQWVYACVEKWLKADENLFQLTKESTPPVGRPLGSKYVNDLANMDTIGKAALADMNNEVDEALSDDEDDGDNEDEDDDGNDVGEDKGDENLEEKQEKNEEEMDDVEQNGSVENQSGDALENETDSTSRGQKRKHCPEMEDEEEESDSDNEDDDTPMSYKALLSDSRKKGRIVPENEDDAVFDVDDEKGHAPANIDEEEDDEDNEDEEVPESDDDDEFEDMAALIERQISDAVDEKDQ
Protein: Myeloid-derived growth factor (MYDGF) (Q9CPT4)
Organism: Mus musculus (Mouse)
Function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway.
Subcellular location: Secreted {ECO:0000269|PubMed:15378209, ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q969H8}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q969H8}. Golgi apparatus {ECO:0000250|UniProtKB:Q969H8}. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q969H8}.
Interaction partners:
- Translocon-associated protein subunit delta
Sequence:
MAAPSGGFWTAVVLAAAALKLAAAVSEPTTVPFDVRPGGVVHSFSQDVGPGNKFTCTFTYASQGGTNEQWQMSLGTSEDSQHFTCTIWRPQGKSYLYFTQFKAELRGAEIEYAMAYSKAAFERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAKAARSEL
Protein: Virion protein (Q77CB7)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MAEDPAAAGALLARALTEELGCLHLVRTDSRVKIYVAVATLGRLLARLVSPEDASPGAAVRVTLYITRPRSLELPPRHFHVLVLFGGAVARACVAGVRTRALVPGSTRVRAVFRDAVAVPAPADLPDPSAEVVPPAPAEHVDPFAFTAFARPPRDAADCFQLAPGVWWSYADRRLYLVQMDEALLALCPAGWRSRSLGGVLGRLLSHPGGCAACTAKWHIDALNAAPEPGACDVCPCAAPCLWKKARRQDVPVAGDSSLFRVLFTDAVARVRILGSRRRPRITGALPELLAGVGPRGEAVPVNGAGWQLRVMDDDVTRLLASSCRAMRSCAAARGSPWG
Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q382G3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
- Phosphodiesterase
- Phosphodiesterase
Sequence:
MTTTKASCLISSDSALRRNSIVATAPLLLLLALTLPVGNGEVTQVNVLSLMYTTEFPVEDAVLFDKGLNVSLMARRLELKGQVKVEFIRPAAPNSPIDVAIEQGAQQSVGKLLLVLGPLGDDNIQIFKGAMEEHELVAFTPIATSSEGYGWDPHLYYLTVGPDAELMALVRYAVGVLGLQRVGVMYVKDTSFSRKSFEFVEKLMMRMGHNISCVFAPESGFSSAGNKVSLDSEWEQFAAALPQAILLLGPRGRDSRWFVMRVAEDNRTSRSHLLAQSGLQSFLLKTWCEALEATGAEFRTGQVIFSGTNPLACDTEYKAVQRFIDETKRYLGNEEEGSEDAGAGGLSNDTGGEMMMLGWMTGEVISAALGNSRVVSNRTAFMESLYYQRRYVVDDLVIGDYGNECGEEAIRQGAVCRCNQGGSMVYMKEMVSKTLLRPVTAGYVTLGMSRCSRESLQLNAPLNALLLLMQDDDVALRANVDWDVGASASVGNGHLTVHDRLFLHSFLATSDAAASILQQLLSVRIVSAVFGVVSDDMLEIEGMTFFDPITTTPRLTKPRKNVIYLSPTMEQQLYVLAEYLYSNPPPSVKAIIRSKEASEISKLLRKTLLTFDAPLSPADILDDDDELGDYLPTEGDVMVIGLTKSDVGTIAEHLETFEESRVFLIFSELALLFEELRAAFRNKASAHRLVFATNLPHWAEIEMPTDRVDNLNSVVPDRSLWSPMALLGFVTGRLMESILERMENVNPGLLADLFFKESLITVDGMWYGPYTDDCDIGKPIEGNHCIHNYGATHISVWSMARVLRSDVPLLQNPTTPSMEYIDPDAIVLTGAAIAGIGIAVFASLLLLAALGALLYFTMNRTRDNASAPKEPMEPVTIIFTDIESSTAIWAAHPELMPDAVAAHHRVIRRLIEKYDCYEVKTVGDSFMIACKGAYPAARLVWELQVSFLNHDWGTGVFDEIYRDAERERRSEDREYNPPTAYLDSEVYSRLWNGLRVRVGIHTGLCDIRRDEVTKGYDYYGQTTNMAARTESVANGGQVLMTRGTYFSLSSTERQEFGVTSLGLVPLRGVPEPVEMYQLDAVAGRVFAPLRFDREACCEQEDGTSTSASDHGSTVAELSESAQWVVASLRAVLRAFSTSQRQKLLMPICERWNVSIPRKPLPMWGEEHCEAIMRSIGAKIGSVVDHPAATDATMTGSTVTNDSVIFISGNPEAQR
Protein: Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) (P48735)
Organism: Homo sapiens (Human)
Function: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P33198}.
Interaction partners:
- Aconitate hydratase, mitochondrial
- Isocitrate dehydrogenase subunit gamma, mitochondrial
- Cytoplasmic aconitate hydratase
- Isocitrate dehydrogenase subunit beta, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Citrate synthase, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Malate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
Sequence:
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
Protein: Xylulose kinase 2 (Atxk-2) (Xylulokinase 2) (EC 2.7.1.17) (1-Deoxy-D-Xylulokinase) (DXK) (Q949W8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates 1-deoxy-D-xylulose (DX) phosphorylation in the cytoplasm prior to the translocation of 1-deoxy-D-xylulose 5-phosphate into plastids. Can also phosphorylate D-xylulose (Xyl). Uses preferentially ATP as cosubstrate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16920870}.
Interaction partners:
- Xylose isomerase
- Sorbitol dehydrogenase
- Ribulose-phosphate 3-epimerase
- Ribulose-5-phosphate-3-epimerase, chloroplastic
- Ribulose-phosphate 3-epimerase
- Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- Transketolase-1, chloroplastic
- Transketolase-2, chloroplastic
- Syntaxin-71
Sequence:
MADLSLPPDSLFLGFDSSTQSMKATVLDSNLNIIKTELVHFDSDLPQYKTKDGVYRDTTVNGRIVSPTLMWVEAFDLILQKLSNANFDFAKVIAVSGSGQQHGSVYWSKGSSEVLRSLDSKRSLKEQLENAFSVKESPIWMDSSTTLQCKEIENAVGGAMELSKITGSRAYERFTGPQIRKLFMTQGEVYKSTERISLVSSFMASLLVGDYACIDETDAAGMNLMDIEKRCWSKAALEATATGLEEKLGKLAPAYATAGSISQYFVQRFGFEKNCVVVQWSGDNPNSLAGLTLSTPGDLAISLGTSDTVFGITKELQPSLEGHVLPNPVDPESYMVMLVYKNASLTREEIRDRCAEGSWDVFNKYLQQTQPLNNGKLGFYYTENEILPPLPVGSHRYILENFSGESLEGVKEQEVGEFDPPSEVRALIEGQFLSKRAHTERFGMPSPPLRIIATGGASANENILSLISAIFGCDVYTVQRPDSASLGAALRAAHGWLCNKKGSFVPISNLYEGKLETTSLNCKLKVKAGDANIASTYGLLMKKRMEIENKLVEKLGHF
Protein: UPF0194 membrane protein YbhG (P75777)
Organism: Escherichia coli (strain K12)
Function: Could be involved in the sensitivity control to chloramphenicol.
Subcellular location: Periplasm {ECO:0000255|HAMAP-Rule:MF_01304, ECO:0000305}.
Interaction partners:
- Probable multidrug ABC transporter ATP-binding protein YbhF
- Probable multidrug ABC transporter permease YbhS
- Probable multidrug ABC transporter permease YbhR
- HTH-type transcriptional dual regulator CecR
- Macrolide export ATP-binding/permease protein MacB
Sequence:
MMKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRNEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE
Protein: U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K) (O43818)
Organism: Homo sapiens (Human)
Function: Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9418896}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 6 homolog
- DDB1- and CUL4-associated factor 13
- Nucleolar protein 56
- WD repeat-containing protein 75
- U3 small nucleolar RNA-associated protein 15 homolog
- rRNA 2'-O-methyltransferase fibrillarin
- HEAT repeat-containing protein 1
- U3 small nucleolar RNA-associated protein 4 homolog
- Nucleolar protein 58
- Nucleolar complex protein 4 homolog
Sequence:
MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAPRKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS
Protein: Ras-related protein RABG3b (AtRABG3b) (Ras-related protein Rab75) (AtRab75) (O04157)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport. Functions in autophagy. Involved in xylem and tracheary element differentiation.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Protein VACUOLELESS1
- Vacuolar fusion protein MON1 homolog
- Vacuolar fusion protein CCZ1 homolog A
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar protein-sorting-associated protein 33 homolog
- Vacuolar sorting protein 18
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 9A
- Vesicle transport v-SNARE 11
Sequence:
MSTRRRTLLKVIILGDSGVGKTSLMNQYVNNKFSQQYKATIGADFVTKELQIDDRLVTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNHLKSFESLDNWHNEFLTRASPRDPMAFPFILLGNKVDIDGGNSRVVSEKKAREWCAEKGNIVYFETSAKEDYNVDDSFLCITKLALANERDQDIYFQPDTGSVPEQRGGCAC