wanglab/gogpt-training-data huggingface dataset:
Protein: SUZ12 polycomb repressive complex 2 subunit (A0A0G2JV08)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAVASGGKSGGGGCGGGGGYSASSSSAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQENKPGSVKPAQTIAVKETLTTEMQTRKEKDTSNETRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESAAPANEDIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL
Protein: Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter) (Q9NRM0)
Organism: Homo sapiens (Human)
Function: High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. May have a residual high-affinity, low-capacity glucose and fructose transporter activity. Transports urate at rates 45- to 60-fold faster than glucose. Does not transport galactose. May mediate small uptake of adenine but not of other nucleobases.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18701466}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:24409316}; Multi-pass membrane protein {ECO:0000269|PubMed:14739288}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:18701466}. Apical cell membrane {ECO:0000269|PubMed:24409316}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:24409316}; Multi-pass membrane protein {ECO:0000269|PubMed:14739288}.
Interaction partners:
- Solute carrier family 22 member 12
- Solute carrier family 22 member 11
- Broad substrate specificity ATP-binding cassette transporter ABCG2
- Sodium-dependent phosphate transport protein 1
- Na
- Organic anion transporter 3
- Solute carrier family 22 member 6
- Solute carrier family 22 member 13
- Sodium-dependent phosphate transport protein 4
- Sodium-coupled monocarboxylate transporter 1
Sequence:
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
Protein: Glucose-6-phosphatase 3 (G-6-Pase 3) (G6Pase 3) (EC 3.1.3.9) (Glucose-6-phosphatase beta) (G6Pase-beta) (Ubiquitous glucose-6-phosphatase catalytic subunit-related protein) (Q9BUM1)
Organism: Homo sapiens (Human)
Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:13129915}; Multi-pass membrane protein {ECO:0000269|PubMed:13129915}.
Interaction partners:
- Hexokinase-4
- Hexokinase-3
- Hexokinase-2
- Hexokinase HKDC1
- GDH/6PGL endoplasmic bifunctional protein
- Glucose-6-phosphate 1-dehydrogenase
- Hexokinase-1
- Glucose-6-phosphate isomerase
- Galactose mutarotase
- Glucose-6-phosphatase catalytic subunit 1
Sequence:
MESTLGAGIVIAEALQNQLAWLENVWLWITFLGDPKILFLFYFPAAYYASRRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQAPAQVHQFPSSCETGPGSPSGHCMITGAALWPIMTALSSQVATRARSRWVRVMPSLAYCTFLLAVGLSRIFILAHFPHQVLAGLITGAVLGWLMTPRVPMERELSFYGLTALALMLGTSLIYWTLFTLGLDLSWSISLAFKWCERPEWIHVDSRPFASLSRDSGAALGLGIALHSPCYAQVRRAQLGNGQKIACLVLAMGLLGPLDWLGHPPQISLFYIFNFLKYTLWPCLVLALVPWAVHMFSAQEAPPIHSS
Protein: Peptide encoded by miPEP165a (P0DKI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory peptide encoded by the primary transcript (pri-miR165a) of the microRNA miR165a that enhances the accumulation of its corresponding mature miRNA. Acts as a transcriptional activator of its corresponding pri-miRNA. Addition of synthetic miPEP165a increases the abundance of miR165a, with consequent increase of root length.
Interaction partners:
- B3 domain-containing protein REM13
- B3 domain-containing protein REM12
Sequence:
MRVKLFQLRGMLSGSRIL
Protein: Uncharacterized protein YcaI (P37443)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tetraacyldisaccharide 4'-kinase
- Protein Smf
- DNA utilization protein HofQ
- DNA utilization protein YhgH
- Inner membrane ABC transporter permease protein YdcV
- Interstrand DNA cross-link repair glycosylase
- ATP-dependent lipid A-core flippase
Sequence:
MKITTVGVCIISGIFPLLILPQLPGTLTLAFLTLFACVLAFIPVKTVRYIALTLLFFVWGILSAKQILWAGETLTGATQDAIVEITATDGMTTHYGQITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQHQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHLMAISGLHIAFAALLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIPLVTFITVPLILAAMVVHLSGPLILEQGLWFLADRSLALLFWGLKSLPEGWINIAECWQWLSFSPWFLLVVWRLNAWRTLPAMCVAGGLLMCWPLWQKPRPDEWQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIRSPLNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTGDIEAPAEQKMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPHQGQTTVNFSAQGWRISSLREQILPRWYHQWFGVPVDNG
Protein: Adenylate cyclase activating polypeptide 1 (Pituitary adenylate cyclase-activating polypeptide) (Q58FG9)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MCSKALLALLVYGIIMHCSVYCSPAVGLQYPALRLEEEVYDEDGNTLQDFAYEQEPLGVAGPPSALGEVYALYYPPGKRHADGIFSKAYRKLLGQLSARKYLHSLMAKRVGGASSGLGDEAEPLSKRHIDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRVAYL
Protein: Cytochrome p450 78a9 (F4IX02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MATKLDTSSLLLALLSKCSLLTQTNLALSLLVASLASLALSLFFWSHPGGPAWGKYFLHRRRQTTVIPGPRGLPFVGSMSLMSNTLAHRCIAATAEKFRAERLMAFSLGETRVIVTCNPDVAKEILNSPVFADRPVKESAYSLMFNRAIGFAPYGVYWRTLRKIASNHLFSPKQIKRSETQRSVIANQIVKCLTKQSNTKGLCFARDLIKTASLNNMMCSVFGKEYELEEEHEEVSELRELVEEGYDLLGTLNWTDHLPWLSEFDPQRIRSRCSNLVPKVNRFVNRIISDHREQTRDSPSDFVDVLLSLDGPDKLSDPDIIAVLWEMIFRGTDTVAVLIEWILARMVLHPDIQSTVHNELDQIVGRSRAVEESDVVSLVYLTAVVKEVLRLHPPGPLLSWARLAITDTIIDGRRVPAGTTAMVNMWAIAHDPHVWENPLEFKPERFVAKEGEVEFSVLGSDLRLAPFGSGRRVCPGKNLGLTTVTFWTATLLHEFEWLTPSDEKTVDLSEKLRLSCEMANPLAAKLRPRRSFSQKNKIKNKESKGNKKKESYKKY
Protein: Vacuole membrane protein KMS2 (Protein KILLING ME SLOWLY 2) (F4I8Q7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the early secretory pathway. Required for the correct export of secretory products from the endoplasmic reticulum (ER) and involved in the maintenance of ER integrity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21294794}; Multi-pass membrane protein {ECO:0000303|PubMed:21294794}.
Interaction partners:
- Hypthetical protein
- SUN domain-containing protein 1
- CwfJ-like family protein
- Protein SINE1
- Zinc finger protein WIP3
- Protein SINE2
- Meiosis-specific protein ASY2
- SUN domain-containing protein 2
Sequence:
MGYGNRASSKTPAISGLREKHQQDLEKLTLTSQPFKTLRLFVVAVFLYVRRWSSYLLANVGWLILFCSIFVAFAALLVTLDGPHVKHVEELSEYTRFGLWWIFLGVASSIGLGSGLHTFVLYLGPHIALFTIKVMQCGRVDLKSAIYDTIQLKRSPSWLDKPCHEFGSPVFSSGVPLSSILPQVQIEAILWGLGTALGELPPYFISRAASLSGGKMKELETCSGDDNGFIAKRVNQIKSWLLSHSQYLNFFTILILASVPNPLFDLAGIMCGQFEKPFWEFFLATLIGKAIIKTHIQTVFIICVCNNQLLDWVENELIYILSFVPGFASALPELTAKLRLMKEKYLIASPPVSSDINVKKWDLSFASVWNGVVWLMLLNFFGQIVTSTAQRYLKKQQEEELDALTNKSSLTSKKSK
Protein: G-protein coupled receptors family 1 profile domain-containing protein (Q22895)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Guanine nucleotide-binding protein G
- G-protein coupled receptors family 1 profile domain-containing protein
- Guanine nucleotide-binding protein alpha-12 subunit
- G-protein coupled receptors family 1 profile domain-containing protein
- Muscarinic acetylcholine receptor gar-2
- Muscarinic acetylcholine receptor gar-3
- Serotonin-gated chloride channel mod-1
- Transporter
- Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
- Guanine nucleotide-binding protein subunit beta-1
Sequence:
MARAVNISPFASYTVVPITSAWPPDDLKADRVQLASFTTGKALLAIAILAMIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALIDLLFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIMMYIACVWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIWRAAKRLAAQDRLMSHCNSVDASERPRNGSAETKDFLNEKETIDVPKKERANSTNSRLFKLERKYLHRPSAFFSAAKGPLIRQTEKSECKARKTLGVIMSVFIICWLPFFILAIFKSFGMWIPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFREMLACRCATLQTVMRQQSFTSRYGPPVRYRTQSSSYRPLLSRRNDSHEASDV
Protein: [histone H3]-lysine(36) N-trimethyltransferase (EC 2.1.1.359) (SET domain-containing protein 2) (A0A8I5ZLS2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAGDTFPATEESSPPKSRVELGRIHFKKHLLHVTSRPQLATTTTVASLLPPTTQLPVAIAESTVDSPPSSPPPPPPPPQVSSPSPPAPISEPVALPHPPVTALMTSTPGPLPVDAAVRAQKEPPMKSVPESLELDMKQDIVSNSLEEHTNQTLKEQADNALQKEDSHIGKEEEVSDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSSQRSHDLKSSTSIEKERDFKKSSAPSKSEDLGKSSRSKTERDDKYFSYSKLERDTRYVSTRCRSERDRRRSRSRSRSDRVSRTSLSYSRSERSHYYDSERRYHRSSPYRERTRYSRPYTDNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRDCKTETSYLEMERRGKYSSKLERESKRTSEHEAIKRCCSPPNELGFRRGSSYSKHDNNSTSRYKSALSKSISKSDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKIPEREKTGSPSPSNQLNDSPTFKKLDESPILKPEFIGHDSHESIKELELPKMKNDQLRNFCSIELNVNGSPETETDVATFRTSKPDAISMTSDDSVTGSEVSPLIKGCVLSSNGFQSVGRCRERDADDACRQHNKSKSPFRETEPLLSPHHDKVMSLPVKTIDYSKTLIKEPVDKRHSCCKTKDSDRYCSPNESSEAENREISSNCFVNVHLDSKTVVCDNRELTDQHSEFTCDGYKQSIGSTSSASLNHFDDLYESVGSSGISSLQSLPSGIRCEENTSPALDTVQSKKGIDFLKYVGKETDVVSALPDSGKAFSSWENRHNMLSGQSLQESQEEGSSTLHERRGRSEVSLDEEEQRGHTHISDDSEVVFPYDLNLTMEDSDGVTYTLKCDSSGNAPEIVSTVHGDYSASSASSSDESDSEDTESDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDGLESRRHAYEEKFESMASKGCSQTEKFFLHKGTERNPETSYSQFSRKIDNHLPEIAHSQSDGVDSTSHTDVKSDSVGHLNSEDAIRAKMSRPQELPVYCDDFEDLPNTSRQQMIFSNRPDSSRLGKAELSFSSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQSAEHYGGTHDYWQGNGYWDPRSAGRPPGTGVVYDRIQGQVPDSLTDDREEEENWDQRSGSHFSSPSNKFFFHQKDKGSVQAPEISSNSIKDSLVINERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEIEQGQSSVPQHSELVGPSCAMDDFRDPQRWKEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEVACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLKLIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSENTSRAHTPLNTPDPSAKPSTEVDTDTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQLETVTVEEDEELQSQQLLPSQLCESKVESESTIDVSKLPISEPEADTETEPKDSNGTKLEETIAEETPSQDEEEGVSDVESERSQEPPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKESTVTERGRDTAAFRDQTAPKTPNRSREREPDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTESLAAPPSVPVVPHGAASVEVSSSQYAAQSESVVHQDSSVPGMPVQTPGPVQGQNYSVWDSNQQSVSVQPQYSPAQSQATIYYQGQTCSTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPPEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKTSKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE
Protein: GTPase activating protein and VPS9 domains 1 (H0Y4E7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIGQQLAAITAWDSSATNITSHITVVTPFATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPF
Protein: DREAM (LD13366p) (STRICA) (Ser/Thr-rich caspase, isoform A (EC 3.4.22.-)) (Ser/Thr-rich caspase, isoform B) (Q7KHK9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Death-associated inhibitor of apoptosis 1
- Caspase Dronc
- RE32990p
- Death-associated inhibitor of apoptosis 2
- Transcription factor E2F2
- Protein lin-54 homolog
- LD07342p
Sequence:
MGWWSKKSETDRSQPSQELVAQDPRTRVQTTSAATETTNTAVQNSTITDNNKQTVTFLTTRQTVTHTQRALITETTTRRTPSQAELEALFAKIKMGGEGPIGSTTTTTTTTSSRSRPPSLNGVSFRSTQPFKATASNAGKRSSTLVKTEQTTVTQKNGRTVTQHLETHRVDLKGSRPKATWASFASTANSSTSSYVSPYRQKPSMAITCTSPNIKTPKTTSSTSSSSASSITSPPKPSSSVSSISSIFKSAPKQVDKPLSSTATPKPFISLGSSGGTKPKVTAVAQSQDAQGTISTSLGISKSSLTKNKLKPARVYIFNHERFDNKNEFRKGSAQDVKVLRATFEQLKCKVEVITDATLVTIKKTVRMLQTKDFEDKSALVLVILSHGTRHDQIAAKDDDYSLDDDVVFPILRNRTLKDKPKLIFVQACKGDCQLGGFMTDAAQPNGSPNEILKCYSTYEGFVSFRTEDGTPFIQTLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQIPSVTSTLTSKYVFGDYI
Protein: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (Q4Q3K1)
Organism: Leishmania major
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating
- Glucose-6-phosphate isomerase
- 6-phosphogluconolactonase
- phosphoglucomutase
- pyruvate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase-like protein
- Pyruvate kinase
- Pyruvate kinase
Sequence:
MSEEQSHADQDAYVADVDGILDVLRAEVLERKPDDVFQFISQSALSLQKDRGAESCDRINCKVTDEQKSRALTIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNVIGYARTKVDDAERWKRETLMTYFSNVPERACHAEDFLKHISYFCGSYDKVDDFKRLDAVIREKENAFKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEVGGWARVIIEKPFGRDTKSSAELSRALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNSNNIACVQITFKETIGTEGRGGYFDGIGIIRDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTASADGSIPGYQEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFKDEVHPYGEATQRNELVIRAQPSEAMYVKITTKVPGLSGDLRQTHQTELDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDCGEIKPIPYQAGTRGPKEADEFITNNGFKHQKGYQWLPSNKL
Protein: Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1) (O35130)
Organism: Mus musculus (Mouse)
Function: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92979}.
Interaction partners:
- Nucleolar protein 58
- Nucleolar protein 14
- Nucleolar complex protein 4 homolog
- U3 small nucleolar RNA-associated protein 4 homolog
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 6 homolog
- Bystin
- Nucleolar protein 6
- rRNA-processing protein FCF1 homolog
- Periodic tryptophan protein 2 homolog
Sequence:
MSAASGGFQPRERRFSVQEQDWETTPPKKLRLGAGSKCGGRRLIVVLEGASLETVKVGKTYELLNCDRHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPSSDPVVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI
Protein: Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside cotransporter) (SPNT) (Solute carrier family 28 member 2) (O88627)
Organism: Mus musculus (Mouse)
Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein {ECO:0000255}. Apicolateral cell membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Equilibrative nucleoside transporter 2
- Equilibrative nucleoside transporter 1
- Equilibrative nucleoside transporter 3
- Equilibrative nucleoside transporter 4
Sequence:
MEKSKGRKSVSQATVENCMENPGLELMEGGNLEQRYTQEEVTQGHSLEDGLGHSSLWSRRIFQPFTKARSFFERHAGLFRKILLGLLCLAYAAYFLAACILNFQRALALFVITCLVIFILACHFLKKFFPKEQLRCLKPLENTHLNLWAKRVFVGLSVVGLILWLALDTAQRPEQLISFAGICMFILILFACSKHHSAVCWRTVFWGLGLQFIFGILVIRTEPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLVQNVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKVAWFLQITMGTTAAETLAVAGNIFVGMTEAPLLIRPYLADMTISEIHAVMTGGFATIAGTVLGAFISFGIDASSLISASVMAAPCALALSKLVYPEVEESKFKSKEGLKLPRGEERNILEAASNGATDAISLVANVAANLIAFLAVLAFINATLSWLGEMVDIHGLSFQVICSYVLRPMVFMMGVQWADCPLVAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIITTFSLCGFANLSSIGITLGGLTSMIPQRKSDLCKIVVRALFTGACVSFISACMAGILYVPRGAETDCVSFLNTNFTNRTYETYVCCRELFQSTSLNGTNMPSFSGPWQDNVSSLRNLASCCDLYTSTVCA
Protein: Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP2) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] (P53565)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P53564}.
Interaction partners:
- BCL11 transcription factor B
- T-box brain transcription factor 1
- DNA-binding protein SATB
- Forkhead box protein P2
- Paired box protein Pax-6
- Protein CASP
Sequence:
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDLGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEDVKKELTTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQASSTASSGNSDDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILNPKLLSASPMSTVSTYPPLAISLKKTPAAPEASTSALPSAPALKKEAQDAPTLDPPGSADATPGVLRPVKNELVRGSTWKDPWWNPVQPERRNLTTSEETKADETNASGKEKTGSSQPRAERSQLQGPSATAEYWKEWPNAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPTIETSKEGKPPEPSDPPTSDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEAADTEEPGGNIVATKSQGGPAEVTAAPADREEATQPAEKAKAQPLSSGTPGQDDGEDAGRSRPPPEGLADAPAPVPNLAAPAAGEDAATSATAPAMATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAGARDNPVRKKKAANLNSIIHRLEKAASREEPIEWEF
Protein: Silencing boundary-establishment protein FUB1-like protein (Proteasome inhibitor PI31-like protein SPAC15E1.10) (Q9UTI1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in the establishment of transcriptional silencing boundaries, preventing the propagation of heterochromatic silencing.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MNNPTSDDRLRFQQKCHKSMLNTGAIFKNCKLRNGDVLQEVTESLTEDSEFNYIVNESQNVSTRLIFWNKWIYILCANTSSNITATRIFRLDDDQPWNLESLVAEVCPVDTDNRLAEHAARTAKDTSANELNYESYQEKSRAPFGFAGPFGAMPGSQPMFPSIGASDLYPAGIGGSDMGNDGGMIPTFNHPIFHPENRSRNEQASANRTNIPPGARYDPTGPGDFRGFGRDERKPQFPFKGPRSQFPGEPDNDDFMPPGSSDMFM
Protein: GH09281p (Q9VPV7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL16
- FI01658p
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein eL21
Sequence:
MGKKQKMKKAAQMATAAEKLKTAAEKSKTAADNVVAKEKPAEEASPSPSGSGKKGKPKATQKPNVAKALQKEISSSEDALDVKNKPPAGFSGAKGKPHIMGQMDPAYRNKIKKLMSLAKQLPPNVFSLPNSQKEEGASAAKSCVVEDDQSTDSDDAPDLVEADPKETQPDEQGQLGTVAVRTREVSKQSRGERKARRILMKLDLKPMENVARVTMKKGKNILLYIDQPDVYRVAHSSTYIFFGEICVEDTSTTSVASQAAVKAAERFRGTSPAGRQGNEDGKAPGEESPHDDDDDENDGEDADAMGLHAKDIELVQMQAACSRKKAIQALLKNDNDVVNAIMALTVG
Protein: Small ribosomal subunit protein uS4c (30S ribosomal protein S4, chloroplastic) (P0C486)
Organism: Oryza sativa (Rice)
Function: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MSRYRGPRFKKIRRLGALPGLTRKTPKSGSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKSSTGQVLLQLLEMRLDNILFRLGMASTIPEARQLVNHRHILVNGRIVDIPSFRCKPRDIITTKDNQRSKRLVQNSIASSDPGKLPKHLTIDTLQYKGLVKKILDRKWVGLKINELLVVEYYSRQT