wanglab/gogpt-training-data huggingface dataset:
Protein: Cell surface glycoprotein CD200 receptor 2 (CD200 cell surface glycoprotein receptor-like 2) (CD200 receptor-like 2) (CD200 cell surface glycoprotein receptor-like c) (CD200RLc) (Cell surface glycoprotein OX2 receptor 2) (Q6XJV6)
Organism: Mus musculus (Mouse)
Function: According to PubMed:15187158 it is a receptor for the CD200 cell surface glycoprotein. According to PubMed:16081818 it is not a receptor for the CD200/OX2 cell surface glycoprotein. Involved in the recruitment or surface expression of the TYROBP receptor.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- OX-2 membrane glycoprotein
Sequence:
MHALGRTPALTLLIFIYNFVSVYTIVSVQMGTKARLCCRSIPLTKAVLITWIIKPRGQPSCIMAYKVETKETNETCLGRNITWASTPDHIPDLQISAVALQHEGNYLCEITTPEGNFHKVYDLQVLVPPEVTYFLGENRTAVCEAMAGKPAAQISWTPDGDCVTKSESHSNGTVTVRSTCHWEQNNVSAVSCIVSHSTGNQSLSIELSRGTTSTTPSLLTILYVKMVLLGIILLKVGFAFFQKRNVTRT
Protein: T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (Q38DP9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU365042}.
Interaction partners:
- T-complex protein 1 subunit delta
- CCT-theta
- CCT-beta
- T-complex protein 1 subunit epsilon
- T-complex protein 1, zeta subunit, putative
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit alpha
- Phosducin domain-containing protein
- Prefoldin, putative
- Prefoldin subunit 3
Sequence:
MIQPQLILLREGTDASQGKPQLISNINACMNVVDTVKTTLGPCGMDKLIHNGREVNISNDGATIMNLLEVVHPAAKCLVDIAISQDHEVGDGTTSVVVLAGELLKEAKNCVEDGIAPQVIIKAFRNALSVVMEALQKLCVPFDPNAEEGRRNLVRCAETALNSKLINTERYFFAKMATDAVLSLDNDLNLDMIGIKKVPGGSMGESILVDGVAFKKTFSYAGFEQQPKKFQCPKVLLLHVELELKAEKDNAEVRVKDPKQYQSIVDAEWKIIFDKMEKCVRSGAKIVLSRLPIGDIATQYFADRDIFCAGRVAADDMARVALATGGVVQSTVSNITEDVLGSCALFEERQVGPERYNFFTGCRNSKTVTIILRGGAQQFIDEADRSLHDAICIVKRAYRTGSVVGGGGAVEMELSKVLREYSRTIRGKGQMVISGFARALEVIPRQLAENAGHDSTDSLNKLRQKHHASDQSGKWYGVDILHGGVCDTFERFVWEPTLVKRNAIQSATEAACLVLSVDETVTNPESEAGKKQAAAGRGGGAMPVSKAGMGGLFKGAPGVTRMKGRAGR
Protein: Probable conserved transmembrane protein (P95017)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable carboxylic ester hydrolase LipM
- Uncharacterized protein Rv0559c
- Probable membrane protein
- Probable integral membrane nitrite extrusion protein NarK3
- Probable cytoplasmic peptidase PepQ
Sequence:
MTNWMLRGLAFAAAMVVLRLFQGALINAWQMLSGLISLVLLLLFAIGGVVWGVMDGRADAKASPDPDRRQDLAMTWLLAGLVAGALSGAVAWLISLFYKAIYTGGPINELTTFAAFTALIVFLVGIVGVAVGRWLVDRQLAKAPVRHHGLAAEHERAADTDVFSAVRADDSPTGEMQVAQPEAQTAAVATVEREAPTEVIRTTESDTPTEVIRTDTEADQTKPGDEPKKD
Protein: Transcription factor TAC1 (Transcriptional activator of CDR genes 1) (Zn(2)-Cys(6) DNA-binding domains containing protein 2) (A0A1D8PN96)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:15590837, ECO:0000269|PubMed:19561319}.
Interaction partners:
- Pleiotropic ABC efflux transporter of multiple drugs CDR1
- Multidrug resistance protein CDR2
- Sterol uptake control protein 2
- Lanosterol 14-alpha demethylase
- Multidrug resistance protein 1
- Sphingoid long-chain base transporter RSB1
Sequence:
MDTSSSSGTHPSTFNNLTKQQELTGNDPNDTNRKRIRVACDSCRRKKIKCNGSYPCGNCIQAKNTSNCHFTERPVRKKLKPTKQDNKSTANSNGVSKRKYNDTFSGNSINIKTEKQENTTFGINDNKSSDLESRLSRIENSMSRMMHTLENFSQNFMTQAIRNNHSNSSMFNNNSLSPTPSEDFNKSAFDSEEQQTSHSYKNLKDRVKDANELLKLRNWDEFVGTHSITCIFSRESLDWMEKTLGSYGEEYLTPIRNLPLVFHSELKPYIMKWIDPPVVDKLQRKKLLESPFPTDSKLISKLIDLYYEETSMINILVDESRVRSLFAAYYNNFAEPIATKRRRFKLSELLLMTSILLISLSCLTEDDFSEERITTPASSTSSNYSAASANLLGDYNKNRLIALQNSLENSAIFYYHRISVISEGLETVEALLMFIIYVESNWLTSFFNYTIITVTIRFAQEIGLHRAETYNNLDLEEATKRRKIWWFCYFFDIEFSFKSGKPPVINTNDVTTNSDEDLLRVITQLKQYGPLSPKDRMYSPVCHTISTSLLDLSGSDSICLDILKIIQSGDILDDPFYFQFCALLQSRIRSNSYHDLFIASAEKRDFSSISNTLEKLNADMFELAMYLADEAKPRFYNDPKFTSVQASTGTSIRRDTILAMKLTFFSHLMIINRYPLMIATEDSKFDDRVIKFRNLSLDSARTILMLIKGWHRESASALFYNWAIYFPVAAYLVLVAAIINHPQLPESGTNLNLLIETSLSFFKSSKQWNSSNDSQDKQQNSTICVNKIVAIELIVRLMLRVVIKVYELHNNVEILANNPALQNHLQEAEEKFPDIFQNHAEFTSKMIALVGASPFGGCGSRNTSSCNLRDNSTNHGQNNMNPSPTITNNTYNSNINTGSNSTGEPQVCYAQSPSYNASLSNIINNESTGRSPATSTSINQSMMNENYDLFNDYLIDNSAVNLPFSQFNNLPNFFFDNNLGI
Protein: Taste receptor type 2 member 110 (T2R110) (Taste receptor type 2 member 10) (T2R10) (Q9JKE8)
Organism: Rattus norvegicus (Rat)
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MFLHTIKQRDIFTLIIIFFVEITMGILGNGFIALVNIVDWIKRRRISSVDKILTTLALTRLIYAWSMLIFILLFILGPHLIMRSEILTSMGVIWVVNNHFSIWLATCLGVFYFLKIANFSNSLFLYLKWRVKKVVLMIIVVSLIFLILNIFSLEIYDHFSIDVYEGNMSYSLGDSTHFPRIFLFANSSKVFLITNSSQVFLPINSLFMLIPFTVSLVAFFMLIFSLWKHHKKMEVNAKGPRDASTTAHIKALQTGLSFLLLYAIYLLFIVIGILSHKFMGGKLILIFDHICAIVFPISHSFVLILGNSKLRRSTLSVLRFLRCRSKHIHIMDP
Protein: Zinc finger protein 473 (A0A8I5Y2B3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MERKEEELKRSHWNQAAMAEEFVTLKDVAMDFTLEDWEDLESELGQRDLFWDATLNNYQDLFSFKATEAKNPPLQSGFLEEDLSQIMEIFSTEELNFESCIGENWFDSFLGDPESLPRPDISNKESPTDRRCHESESGLSPGPPHCTREGAVMSDSPEKNLDPVILKESRSDLSQQDSVQGQEKLYKCSECGKSFSQSYHLIQHWVIHARGELPAWQEQPGALSKGALLLMQPGTQTSSESYVCQECGKSFSQNMYLQWHQKIHTGEKLCKTQSDNLEKPSKGPSDEPGKQLVSEAADSAKLCDSRGWDQEKPPTNKRHDREDLHKGQYGDSPSVLHPKPIKHQKTATRAKCFRCRRCGKTFSWAFHLADHQKVHTQRLYGCTSCPAVFNLRKHFFQHRKTHFAKTVFECQECRKLFNRRSSLIKHQAVHTGEKPYKCNECGKAFNHFSTLKIHQRIHSGEKPYTCSECGKTFSRRTALTEHHRVHSGFRPHQCPVCPRRFSRPSHLTRHQLSHAAERLFGCAKCKETFGHKEQLERHYKSHTIECSYECKQCGEHFICSSTLNCHLSIHIRENTSEKVSGQHSQHTEKCFKNTKCGKAFNHSKYPEQHEKIHAKVASCEQSPCRNTCDQSMQPIHCQSSCAAVKPNKCTEPEKCIRNTSVSQHQPSQSEPPFKCNTCNRTFKQSAHLSNHQLIHTTEKPFKCKECDRAFKHSNYLIQHQKIHSVKDFECSECGKKFHQKSCLSKHQKIHSGQKPFKCADCGKAFIFSAQLIRHQRIHTGEKPYVCQECGKAFSQSSCLTLHLRTHTGEKPYTCSTCGKAFSQKANQRKHERTHSGEKPCACDVCGKSFGFSTHLRQHQRIHTKEKPRCQDCHKAFHSFSALSEHQKLHTCTAASTTAQSHLLTAEARASEGPHLEPAIETSTLQTSPPHSPNKNQ
Protein: Protein kinase YopO (O85239)
Organism: Yersinia enterocolitica W22703
Interaction partners:
Sequence:
MKIMGTMPPSISLAKAHERISQHWQNPVGELNIGGKRYRIIDNQVLRLNPHSGFSLFREGVGKIFSGKMFNFSIARNLTETLHAAQKTTSQELRSDIPNALSNLFGAKPQTELPLGWKGKPLSGAPDLEGMRVAETDKFAEGESHISIIETKDNQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRKEEALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQILKDTLTGEMSPLSTDVRRITPKKLRELSDLLRTHLSSAATKQLDMGVVLSDLDTMLVTLDKAEREGGVDKDQLKSFNSLILKTYSVIEDYVKGREGDTKSSSAEVSPYHRSNFMLSIAEPSLQRIQKHLDQTHSFSDIGSLVRAHKHLETLLEVLVTLSPQGQPVSSETYSFLNRLAEAKVTLSQQLDTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTADSIPLLIRLGRSSLIDEHLVEQREKLRELTTIAERLNRLEREWM
Protein: 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7) (P34969)
Organism: Homo sapiens (Human)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22448645}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- 5-hydroxytryptamine receptor 6
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
Protein: V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (Vacuolar proton pump subunit E 1) (Q6PCU2)
Organism: Rattus norvegicus (Rat)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P36543}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit F
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit D
- V-type proton ATPase subunit
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase 16 kDa proteolipid subunit c
- Vacuolar proton pump subunit B
Sequence:
MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKKDVDVQIDLEAYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD
Protein: Probable protein phosphatase 2C 80 (AtPP2C80) (EC 3.1.3.16) (Q9LVQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable protein phosphatase 2C 52
- 60S ribosomal protein L36
- Putative protein phosphatase 2C 53
- Probable protein phosphatase 2C 54
- Putative protein phosphatase 2C-like protein 45
- Putative protein phosphatase 2C-like protein 44
- Probable protein phosphatase 2C 71
Sequence:
MSATALSRLNPVSQFGFQRIVAGKSKSFFSNSGQRRLFSDSSRFRQAMAASGSLPVFGDACLDDLVTTCSNGLDFTKKRSSGGSFTINCPVASMRLGKRGGMMKNRLVCHYSVVDPLEKSRALFGTLSKSVHTSPMACFSVGPAHELSSLNGGSQESPPTTTTSLKSLRLVSGSCYLPHPEKEATGGEDAHFICDEEQAIGVADGVGGWAEVGVNAGLFSRELMSYSVSAIQEQHKGSSIDPLVVLEKAHSQTKAKGSSTACIIVLKDKGLHAINLGDSGFTVVREGTTVFQSPVQQHGFNFTYQLESGNSADVPSSGQVFTIDVQSGDVIVAGTDGVYDNLYNEEITGVVVSSVRAGLDPKGTAQKIAELARQRAVDKKRQSPFATAAQEAGYRYYGGKLDDITAVVSYVTSS
Protein: Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Q8BLF2)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYFTRDGFIEKFIPELRAKLLQEAKVNSFIKPKENFKENEPVRDEKKSVFTNTLLYGNPSLYGKEVDRDKRAKELKVRVIKAKGGKGDVPDQKKPEYEGDHRQQGTADDTQPSSLDKKPSVLELTNPLNPSENSDGVKEDPHAGGCMIMPPINLTSSNLLAANLSSNLSHPNSRLTERTKKRRTSSQTIGQTLSNSRQEDTGPTQVQTEKGAFNERTGQNDQISSGNKRKLNFPKCDRKEFHFPELPFTVQAKEMKGMEVKQIKVLKRESKKTDSSKIPTLLSMDPNQEKQEGGDGDCEGKNLKRNRFFFSR
Protein: Ribosome biogenesis protein ENP2 (Essential nuclear protein 2) (P48234)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in rRNA-processing and ribosome biosynthesis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14690591, ECO:0000269|PubMed:15590835}.
Interaction partners:
- Essential nuclear protein 1
- Ribosomal RNA-processing protein 9
- Nucleolar protein 58
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 20
- U3 small nucleolar RNA-associated protein 6
- U3 small nucleolar RNA-associated protein MPP10
- rRNA processing protein RCL1
- RNA cytidine acetyltransferase
- U3 small nucleolar RNA-associated protein 18
Sequence:
MVLKSTSANDVSVYQVSGTNVSRSLPDWIAKKRKRQLKNDLEYQNRVELIQDFEFSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDRHTDAENVDFTILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTCDKRIAKIWDRLDGKAYASMEPSVDINDIEHVPGTGMFFTANESIPMHTYYIPSLGPSPRWCSFLDSITEELEEKPSDTVYSNYRFITRDDVKKLNLTHLVGSRVLRAYMHGFFINTELYDKVSLIANPDAYKDEREREIRRRIEKERESRIRSSGAVQKPKIKVNKTLVDKLSQKRGDKVAGKVLTDDRFKEMFEDEEFQVDEDDYDFKQLNPVKSIKETEEGAAKRIRALTAAEESDEERIAMKDGRGHYDYEDEESDEEESDDETNQKSNKEELSEKDLRKMEKQKALIERRKKEKEQSERFMNEMKAGTSTSTQRDESAHVTFGEQVGELLEVENGKKSNESILRRNQRGEAELTFIPQRKSKKDGNYKSRRHDNSSDEEGIDENGNKKDNGRSKPRFENRRRASKNAFRGM
Protein: Ribosomal protein L10 (F8W7C6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPSRGPLDKWRALHS
Protein: NADH oxidoreductase HCR (EC 1.-.-.-) (P75824)
Organism: Escherichia coli (strain K12)
Function: NADH oxidoreductase acting in concert with HCP.
Interaction partners:
- Hydroxylamine reductase
- Iron-sulfur cluster repair protein YtfE
- Uncharacterized protein YcbX
- NADH-quinone oxidoreductase subunit C/D
- Carnitine monooxygenase oxygenase subunit
- Uncharacterized protein YgbA
- HTH-type transcriptional repressor NsrR
- Protein YoaG
Sequence:
MTMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTISSTPGVSEYITLTVRRIDDGVGSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEWRNYPVTLVAENNVTEGFIAGRLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLKFTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTDAEIAEGYVLACSCHPQGDLVLA
Protein: Myotilin (E7FH53)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Uncharacterized protein.
- Nebulin.
- BCL2-associated athanogene 3.
- Telethonin
- Actinin alpha 3b
- DnaJ heat shock protein family
- Alpha-crystallin B chain
- Myozenin-1a
- Phosphoglucomutase 5
- Nebulin-related-anchoring protein
Sequence:
MIKLDSPPKGVKNSVPHPFLLTSKLNKQVESKGSATNVADLPTFSPSLYPPSAFNYERPRHFIQSLPSFHTHDTETSKPNDLCVPATTPAPLVTPPLHAPTQTLMCSSMTLIPKARSTPNSENLSPAAFLSSVLPSPPSCQSKCLSIPQSPRHSSRSPSPTQKVQEPPLSPSNQLRNLPARIPPDTLKTTARSLQSSPVPHITYTSNMLPKPILKKNVSRPVSRATDEDIQGSKDALMQDLEQKLRNKVPQQRNNQQKISYEERMARRLLGADNAASVFHLENSFSSQPAQPGSPEDQYPGGIWSRKKRSGGDSTEASTIQEKCFAPRFIQVPQDVTVEEGRFCRIDFKVVGLPTPDISWYLDGKPIRPDDYHKMLVCEKSVHSFIIEIVTIHHAGLYECIAKNRAGQSQFSLHLDVIAQEQLCPPTFVVKMKNSHAMEGDAVRLECKVNASPSPQLYWKKDKEMLRIDHTRMSLSQDSSGKQCLVINPVMKSDAGWYTVSAINEAGMSTCNARLDVATRLNKTTHPARPLKNLPIVNQFSTLCLDPLVQHTAPLYESEEL
Protein: Nitronate monooxygenase (NMO) (EC 1.13.12.-) (Propionate 3-nitronate monooxygenase) (P3N monooxygenase) (Q9HWH9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates. The toxin propionate 3-nitronate (P3N) is the best substrate (and the presumed physiological substrate), but this enzyme is also active on other primary and secondary nitronates such as propyl-1-nitronate, ethylnitronate, pentyl-1-nitronate, butyl-1-nitronate and propyl-2-nitronate. Is likely involved in the degradation of P3N, that allows P.aeruginosa PAO1 to grow on 3-nitropropionate/P3N as the sole nitrogen source. Also functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism. Cannot oxidize nitroalkanes such as 3-nitropropionate, nitroethane, 1-nitropropane, 1-nitrobutane, 1-nitropentane, or 2-nitropropane.
Interaction partners:
- Uncharacterized protein
- Nitrate/nitrite transporter
- Nitrite extrusion protein 1
- Nitrate/nitrite transporter
- nitrate reductase
- nitrate reductase
- nitrate reductase
- Nitrite reductase
- nitrate reductase
- Periplasmic nitrate reductase
Sequence:
MTDRFTRLLGIQQPIIQAPMLGVSTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTDKPFNVNLFCHRPGQADPARERAWLDYLKPLFAEFGAEPPVRLKNIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGVFEPERGDAAIGTLALVRLLAARGSLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALARGNHDFAAQWAGQGAALARELPAAELLRTLVEELRG
Protein: 5-hydroxytryptamine receptor 2B (5-HT receptor 2B) (5-hydroxytryptamine receptor 1B) (5-HT receptor 1B) (Serotonin receptor 1B) (Serotonin receptor 2B) (P28286)
Organism: Drosophila melanogaster (Fruit fly)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- G protein alpha i subunit subunit alpha 65A)
Sequence:
MLKTVTTAMAAGDDDVPASILEIELPAILLNESLFIELNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARARSAKI
Protein: Rho family GTPase 1 (H0YHG7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
WRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM
Protein: Mannitol 2-dehydrogenase (M2DH) (MDH) (EC 1.1.1.67) (Q2U100)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
Interaction partners:
- Zinc-dependent alcohol dehydrogenase
- Enoyl reductase
- D-xylulose reductase
- L-arabinitol 4-dehydrogenase
- Phosphotransferase
- Phosphotransferase
- Phosphotransferase
- Phosphotransferase
- Carbohydrate kinase PfkB domain-containing protein
- GMP synthase
Sequence:
MAPLKLNNKNLSQIAAAGETQVKVPTYKRGGDVKEGIVHVGVGGFHRAHLAVYVDQLMQKHGVTDYAICGVGLQPFDAAMRDALGSQDHLYTVIERSAKGSFAHVVGSINSYLFAPDNREAVIAKMAHPDTHIVSLTITESGYYYNENTHELQSEHPDIQFDLQPANEKSPRTTFGFLYAALARRYQQGLKPFTVMSCDNMQKNGSITRHMLESFARLRNPEIAKWIAEQGAFPNAMVDRITPQTSATDKTALADNFAIEDSWPVVTEPFMQWVIEDQFSDGRPPFEKVGAQVVKNVHDVEEFEKHKLRLLNGSHSAIGYPGQLAGFKYVHEVMENPLFSKFVWQMMQDEVKPLLPEIPGVNIDEYCKTLIERFSNPTIMDQLPRICLNASGKIPQFIMPSIAEAIWVTGPFRRLCFVAAAWFHYINGVDDSGKKFEVDDPMREELQAKARAGGTSPAELLSIKSLFGDDLRGDKRFLQEITKAMEDIARDGILKTLPKYID
Protein: Centrobin, isoform A (Centrobin, isoform B) (Q9I7U5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Elfless, isoform B
Sequence:
MSDTDTDDTDLLLLIPPNFCAEDKMSACAAADALAMPPPPPPATTSAAYQFLHPSKKSELNSINSRLQNIALDAEEPPSDISTISTNTVRNAGRPSRELHGMVHSTPKSGSVEPLRHRPLDDNILLEIDHYLDDNNAHRWQRHDHHLHHRSDDHLRNERAGKEGHPGTSSLPSMRLASSSSGAVSVEAARVDRSSLNENKIISLSELWGKSSLTKTVLDNNSPNRPLCSSSLKEEQLRRQHLEKMVHTLQSHLLEYQQRISVAIEVDRSKDAALTEAEQTVQSLNYEVQHLRDAVHRLEADRGESQSRFDALQNELSQAVNLATRFQEKNDKLERELDHCRQDAKQWEERLEQLEMQLNSSKRAEELSHAELNKLRDKFAKVDYQQEKLKARIEELEKENNTLTNQKEMLQEYHQKQKARADSLESHRKSLQETLANLTETETNLKKKLDIQQKSLKQYYQQQMENVVAKKMQEFQDQLDKNEEHLKNEARERERLIAERAVKQLEMINEKNNQELNLIQEKHNEEVELYRLQLANASKKIDEMDLKLSCYKTKRADIAEKLHGVMEAQWQQALAILTTPSQNSIIQSSDTEASESPELNNARMYPETPKSSKSQRSNNTEKNNLDVVGKRDPPSPMDKLQAYIELLLSKSPSDFDRLDEILAMTSKQGSKQSKPKSGSGNSKPPPWKC
Protein: Cysteine proteinases superfamily protein (F4I133)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKKNFEVFDFKEEDELAESAAGKLLEKFTNPSPCNSPVLQRQRIQSFCNEKRVEEEEMEGPSCAEPATAVESDDHQCEDDSTLVTEAKESRTILTFGLETTDHLEETDAEHVNQGLMLGLKTEDLAKETDIDHDNHGLMFGLNSEDDIEETDVDHRVESFSCQLGGNSFYAETSSYSQRQLNSPFSDSSSSEEQIDMMSAIDESLSDRSALSEASDSEDDEEGTCYTFSLYFLIDMLGSPMSDRVLISMLYALKDWMTEHCFNDEEKIDLSTAVIMTSEYVILKDMHCAASLVIFSCNGIKIKSFLANNEEVPFSCEFGVEDIVSIQYNWYQNVGLIILRIRVLLKDENCHEDMEELKIAVKEHNWPNKQQKINSLHVKYPAVWNTDLEDDVEVSGYNLNQQKRYFPSFDEPFEDVVYPKGDPDAVSICKRDVELLQPETFVNDTIIDFYINYLKNQIQTEEKHRFHFFNSFFFRKLADLDKDPSSIADGKAAFLRVRKWTRKVDMFGKDYIFVPVNYNLHWSLIVICHPGEVANRTDLDLDDSKKVPCILHMDSIKGSHAGLKNLVQTYLCEEWKERHKETSDDISSRFMNLRFVSLELPQQENSFDCGLFLLHYLELFLAEAPLNFSPFKIYNASNFLYLNWFPPAEASLKRTLIQKLIFELLENRSREVSNEQNQSCESPVAVNDDMGIEVLSERCSPLIDCNGDMTQTQDDQGIEMTLLERSSMRHIQAANDSGMVLRDLFDSGSNNTGSLLEQLQQPFEDPSSFYHLSNDSSAREQVDMETGEQFMCLNAGEGNFQCITETTSPRASNSFSSWNLGIPLVQKEDETDLLSETSNSSNDSIGIIEDNPIENTHEEEIDESPPRETVSLKSATVGSNTADHTTENEEPVSTHIELVVPSSQNDRDEEKPLEHDLEIGDKTSEDVGDDCDQKEPMEEEDEKRAAKRPRLSSPTGEAEEMEK
Protein: Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) (Q8WUA2)
Organism: Homo sapiens (Human)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- Probable ATP-dependent RNA helicase DHX40
- Ubiquitin carboxyl-terminal hydrolase 7
- Peptidyl-prolyl cis-trans isomerase FKBP2
Sequence:
MAVLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGTGRGGESIFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSDQHGSQFLITTGENLDYLDGVHTVFGEVTEGMDIIKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPDRSPEPTREQLDSGRIGADEEIDDFKGRSAEEVEEIKAEKEAKTQAILLEMVGDLPDADIKPPENVLFVCKLNPVTTDEDLEIIFSRFGPIRSCEVIRDWKTGESLCYAFIEFEKEEDCEKAFFKMDNVLIDDRRIHVDFSQSVAKVKWKGKGGKYTKSDFKEYEKEQDKPPNLVLKDKVKPKQDTKYDLILDEQAEDSKSSHSHTSKKHKKKTHHCSEEKEDEDYMPIKNTNQDIYREMGFGHYEEEESCWEKQKSEKRDRTQNRSRSRSRERDGHYSNSHKSKYQTDLYERERSKKRDRSRSPKKSKDKEKSKYR
Protein: Heme A synthase COX15 (HAS) (EC 1.17.99.9) (Cytochrome c oxidase assembly protein COX15) (P40086)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin YAH1 and ferredoxin reductase ARH1.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11248251, ECO:0000269|PubMed:9228094}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protoheme IX farnesyltransferase, mitochondrial
- Adrenodoxin homolog, mitochondrial
- Cytochrome oxidase assembly protein SHY1
- Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
- Protein SCO2
- Protein PET117
- Cytochrome c oxidase assembly protein COX11
- Protein SCO1
- Holocytochrome-c1 synthase
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQLYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTESGLSITEWKPVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFMEWIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSGLDQEQLDARKSKPTVSQYRLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFKKLDNPAIGPMRKISLALLAVSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMDENFCRREDKKDLWWRNLLENPVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTILYLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRNVIITLPHSSKVTSGKILSEASKLASKPL