wanglab/gogpt-training-data huggingface dataset:
Protein: DNAJ heat shock N-terminal domain-containing protein (Q8T867)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Clathrin heavy chain
- Regulator of chromosome condensation domain-containing protein
- BAR domain-containing protein
- Uncharacterized protein
- Luminal-binding protein 1
- Clathrin light chain
Sequence:
MESFTEKMFDFQRRATQAVLQKMGASETTIDEQFENTHTNFKRLGEFLTHLEESTQSSLTQMEKMCFANNQLASSLCNFVLSELSNDDTEFSTGLLSKFFLKTSTNPNLSQMENTKEFELRQSKFQESVQRLYDSFGTMGHENMASTQDEINHKIVRPIKRDQDYNKVTKQLIEKRKKLNLDYDSIKRSNDNEKIKLVKEEFDILSKKTASHLQNRSYVRCKLIVHSVITMVQQFCMFFESNSVLLEGLLTFIEPLIQTYQLNTEQLTDIYTIKKTTTPTTTTTTTSSPSSSSPRQQPFNGSNNNGNTPTGKPIPSSPPPTYKEHLDNNNSNNSNHQQQQQQHQQQQNQQRNNNNNNNNKNNNMNESHQNLNEEFTQKASFQGSPSDSNSSTSSNNYSPQQQQQQQQQQQQQQQQQQQQQQPPPPKEEKLFSVWDDDLNGKSNDDNNTASNSNSKSKSNDDDDWMYNNNSSDNKPNLSRSDTTWEDPLVPENSSYSKPAYSSFNNTPQQPQYFNTQPQQQQQQQFNRQPHQQQQQQQQQQQQPFNRQPSQPYQPPPQQQQQQQQQQQQQQKKSSGFENIFGDFDFTSPSQQRQNPQPPQQQSNYFNNGMPPQSSVSQHVDNHQHERSNVEPIVSEKIKMWGEKGGRKNNLRVLLSTLHEVLWIESGWEKVTYGSLVTPIQVKKVYRKAIIVVHPDKVHNGTMEQKMIAQRIFETLRDQFEVFKVDLEPSN
Protein: EID1-like F-box protein 3 (Q93ZT5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phytochrome A-associated F-box protein
- Protein HUA2-LIKE 3
- F-box protein DOR
Sequence:
MLLEGRFSVVQMNTNRRLKFNQPSRLPNSGKSGIENERVLVLVFESISWDIHTLCTIASLSRRFCAIARRILWRRLCVNRAPGMVAALSGEDPSGRIDGGWHALAKLMFFCGGGESTRYFNLSQPTSGHFACESRFSKTSGRFFLPKNCRRDLLYMSDPCEHQAVGGDEHLGVFRGVFREFMRSKTRECLVRRQAALEEKVRCPYCGGRVWSMTAARLVPKSAARRLGSREGGLEFFVCVNGHLHGTCWLIPLSSEEEDNGEDDDNSDGSVI
Protein: Calcium uniporter protein (A0A8I6A2V9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367035}.
Interaction partners:
Sequence:
MQGKLERSQAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE
Protein: Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1) (Q62398)
Organism: Mus musculus (Mouse)
Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Subcellular location: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q00195}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel beta-1
- Cyclic nucleotide-gated channel alpha-4
- Calmodulin-1
- Calmodulin 5
- Calmodulin-4
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Adenylate cyclase type 3
- Cyclic nucleotide-gated channel beta-3
- Guanine nucleotide-binding protein G
Sequence:
MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSSELQRLAEMDTPRRGRGGFRRIVRLVGIIRDWANKNFREEEPRPDSFLERFRGPELQTVTTHQGDGKGDKDGEGKGTKKKFELFVLDPAGDWYYRWLFVIAMPVLYNWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVAASMEVDVQEKLEQLETNMETLYTRFARLLAEYTGAQQKLKQRITVLETKMKQNHEDDYLSDGINTPEPAVAE
Protein: LP11751p (Q95R90)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004146}.
Interaction partners:
Sequence:
MGYVEERNQDYNAIVEGIRFDDGRTISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQINVDKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEKDIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLRKIRASDNFDILILHVENGRDIFITVTGDYQPSCFGLSMETMCRTDRPLSEYSQDQIKQLMNDESPEYRVTMPREFFLLIDYLYRQGSKQVGAFPSYDSRLSLGAQFNSVRDWLDTWSDDPFPANAETAAQALLLLLDLPEHALLEPVVENLLECTNKSQAMDYISLLSPPKRNVFMHLCMFLRAGIESQFYDLHQVASTFGRILLRSTERAAWMDYHSRCIQFMRLFIDTDVEAMGNGNEGAGTGTGSGSGTRAGLQA
Protein: Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1) (Q64685)
Organism: Mus musculus (Mouse)
Function: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15907}; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Interaction partners:
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
- Beta-galactoside alpha-2,6-sialyltransferase 2
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
- Alpha-
Sequence:
MIHTNLKRKFSCFVLVFLLFAIICVWKKGSDYEALTLQAKVFQMPKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFETYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNNRC
Protein: Alpha/beta-Hydrolases superfamily protein (Lipase-like protein) (Q9M3D1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 98A3
- Flavone 3'-O-methyltransferase 1
- F5F19.5 protein
- Shikimate O-hydroxycinnamoyltransferase
- 4-coumarate--CoA ligase 4
- Cytochrome P450 84A1
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Probable caffeoyl-CoA O-methyltransferase At4g26220
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
Sequence:
MVMYKEDYVSNSRGIQLFTCSWKQEEQQEPKALIFLCHGYAMESSITMSSTAVRLANAGFSVYGMDYEGHGKSGGLNGYVKKFDDLVQDVSSHYSSICELEENKGKMRFLMGESMGGAVVLLLERKKPNFWDGAVLVAPMCKLAEDIKPHPMVISFLTKLTRFIPTWKIVPSNDIIDVAFKETHIRKQVRDNEYCYKGRPRLKTAHQLLMVSLDLEKNLDQVSMPFIVLHGEDDKVTDKNVSKLLYEVASSSDKTFKLYPNMWHGLLYGESPENLEIVFSDIISWLKERASVTNQKLETELKHVDDGFSMQK
Protein: Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1) (O60906)
Organism: Homo sapiens (Human)
Function: Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo. Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O70572}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sphingomyelin phosphodiesterase 3
- Sphingomyelin phosphodiesterase 4
- Sphingomyelin phosphodiesterase
- Protein FAN
- Ceramide glucosyltransferase
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Ceramide synthase 6
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Ceramide synthase 2
- Ceramide synthase 4
Sequence:
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
Protein: GH05001p (RE44258p) (Rab11 interacting protein, isoform B) (Q494I2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.
Interaction partners:
Sequence:
MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPDQGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYDRPRAKWFKLESKPGKEKKNKERGELEVRIAFVVKSGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLHIRSKKKNQEAGADDSSSFGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEADPGVISEDEDEFVFDNLSHKSSGSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVGSGSAKDKYNNDNDSNSPSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEGKSREELMLIANGMENEALLQRQRVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKSG
Protein: Cytidine deaminase, putative (Q38FM3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- thymidine kinase
- Nucleoside phosphorylase, putative
- dTMP kinase
- dTMP kinase
- G domain-containing protein
- Orotidine 5'-phosphate decarboxylase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- glycine--tRNA ligase
Sequence:
MQCSSLKTGCLKLLSQLPEGLQQAGRTAVSAHQRSYCPYSNFAVGAALLHDDGKVTSGCNYETCVYKGTCAEACAIVKANMDGYRTAQAVAIYGRSVLPTAAAAAADATVPPCGFCRQLLAEVADLSGNMNDFLVVLVTFDQEHARLFRLSELLPQPFGPSSIGMDVAALATGEHSRCPGTF
Protein: Epidermal growth factor receptor pathway substrate clone 15, isoform C (Q8MMD3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNVDFARVCGKHIGVYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVDLQPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGGFADFDDFDNKNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDYRYEDPFSIKDPFAEEGEEELSEGKGADHKRNFAEDFSSGDEIGSAAKTLSNIVNNNSIKPKAATPLNNDLLQQFDAFNLNSSPAPSHHSGTSYHSNSKPSHDSQTALDAFADFDDFAATLATTGGSGAATTATTTGNTKLNNSFFDAFNDNFSVIQSSSVPTGVVRPNDQRAKAFDAFNDNFEDQFKTSPNANFAKFDGFEAHNFSSDFGNASFGTTGKEKQNGQVDKKFQSKEPVKDKFAADYSKPESFDADLEEALKRSVLDN
Protein: Interferon regulatory factor 7 (A0ZVR0)
Organism: Sus scrofa (Pig)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAAPDRGCPRVLFGDWLLGEVSSGRYAGLRWLDEARTRFRVPWKHFARKDLGESDSRIFKAWAVARGRWPPRSSEGAQPIPEGALRASWKTNFRCALHSTRRFVMLQDNSGDPTDPHKVYMINPELGCGEGPGFNPGEEEALEDAPPPRGELPGPRLAAHTGERLRHELARPSPEPCTPSPAGDGGDLLLQALQQSCMEDHLLEAAWGVDLTPPEVPYAGPLPAPVPWKPQEAEPCTTLYPRVCTRMAGERGAASPSCSQLGLHAGPSLEALDLTIMYKGRTVLQEMVGGPSCVLLYGSPGPAGAAAEPQQVAFPSPAELPDQKQLHYTEKLLQHVAPGLQLEFRGPKLWARRLGKCKVYWEVGGPLGSGSPSTPACLLPRDCDTPIFDFGTFFQELMEFRARRRQGSPHYTIYLGFGQDLSVGRPKEKSLVLVKLEPWLCRTQLESVQREGVSSLDSGSLSLCLSPSNSLYDELERFLMEVEQPA
Protein: Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2) (O14669)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:17502622}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Transcriptional coactivator YAP1
- Vitamin K-dependent gamma-carboxylase
- Proline-rich protein 12
Sequence:
MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILLIVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQALAASGVHDAPPPPYTSLRRPH
Protein: Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) (O70497)
Organism: Mus musculus (Mouse)
Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Mannan-binding lectin serine protease 1
- Mannose-binding protein A
- Mannose-binding protein C
- Mannan-binding lectin serine protease 2
- Collectin-10
- Calreticulin
- Ficolin-1
- Calreticulin
- Complement C1s-1 subcomponent
- Complement C1r-A subcomponent
Sequence:
MALGSAALFVLTLTVHAAGTCPELKVLDLEGYKQLTILQGCPGLPGAAGPKGEAGAKGDRGESGLPGIPGKEGPTGPKGNQGEKGIRGEKGDSGPSQSCATGPRTCKELLTQGHFLTGWYTIYLPDCRPLTVLCDMDTDGGGWTVFQRRLDGSVDFFRDWTSYKRGFGSQLGEFWLGNDNIHALTTQGTSELRVDLSDFEGKHDFAKYSSFQIQGEAEKYKLILGNFLGGGAGDSLTPHNNRLFSTKDQDNDGSTSSCAMGYHGAWWYSQCHTSNLNGLYLRGPHKSYANGVNWKSWRGYNYSCKVSEMKVRLI
Protein: Protein FAF1 (Forty S assembly factor) (P40546)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for pre-rRNA processing and 40S ribosomal subunit assembly. Seems to act in the processing of 35S rRNA at the A(0), A(1), and A(2) cleavage sites.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:15178413}.
Interaction partners:
- Ribosome biogenesis protein BMS1
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 11
- U3 small nucleolar RNA-associated protein 14
- U3 small nucleolar ribonucleoprotein protein IMP4
- U3 small nucleolar ribonucleoprotein protein LCP5
- Essential nuclear protein 1
- Something about silencing protein 10
- Protein BFR2
- Nucleolar protein 58
Sequence:
MTLDDDDYIKQMELQRKAFESQFGSLESMGFEDKTKNIRTEVDTRDSSGDEIDNSDHGSDFKDGTIESSNSSDEDSGNETAEENNQDSKPKTQPKVIRFNGPSDVYVPPSKKTQKLLRSGKTLTQINKKLESTEAKEEKEDETLEAENLQNDLELQQFLRESHLLSAFNNGGSGSTNSGVSLTLQSMGGGNDDGIVYQDDQVIGKARSRTLEMRLNRLSRVNGHQDKINKLEKVPMHIRRGMIDKHVKRIKKYEQEAAEGGIVLSKVKKGQFRKIESTYKKDIERRIGGSIKARDKEKATKRERGLKISSVGRSTRNGLIVSKRDIARISGGERSGKFNGKKKSRR
Protein: 2-nitropropane dioxygenase-like protein (Aldolase-type TIM barrel family protein) (Putative 2-nitropropane dioxygenase) (Q9FMG0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 72A14
- Cytochrome P450 72A15
- UDP-glycosyltransferase 73B4
- Ras-related protein RABD2b
- Jasmonate-induced oxygenase 2
- Isocitrate dehydrogenase catalytic subunit 5, mitochondrial
- Jasmonate-induced oxygenase 3
Sequence:
MKGILGFEYGIVQAPLGPDISGPELVAAVANAGGIGLLRCPDWECPDYLRELIRKTKTLTEKPFGIGVVLAFPHDLNIKTILEEKVAVLQLYWGDCSQELVDDAHFAGVKVIPQVGNVEEARKAVAVGVDAIIVQGREAGGHVIGKDGLFSLLPRVVDLVGERDIPVIAAGGIVDGRGYVAALSLGAQGVCLGTRFVATHESYAHPIYKRKLIEYEKTEYTDVFGRARWPGAPQRVLETPFFDDWRSLPAHENEVNQPIIGRSTIHGVEKEIRRFSGTVPNMTTTGDLESMAMYAGQSVGLIKEILPAGEVVKSLVEEAQALILQKFNNATTT
Protein: Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) (Q9CYV5)
Organism: Mus musculus (Mouse)
Function: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000305|PubMed:27863209}; Multi-pass membrane protein {ECO:0000305}. Peroxisome membrane {ECO:0000305|PubMed:17768142}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal membrane protein 4
Sequence:
MAALSKSIPHNCYEIGHTWHPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHKGTPRAMSIIALVRTLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVTPELPIDFS
Protein: Metacaspase-8 (AtMC8) (EC 3.4.22.-) (Metacaspase 2e) (AtMCP2e) (Q9SA41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cysteine protease that cleaves specifically after arginine residues. Does not cleave caspase-specific substrates. May be involved in the modulation of programmed cell death activated by oxidative stress.
Interaction partners:
- Peroxidase 20
- Peroxisomal membrane protein 13
- Peroxidase 10
Sequence:
MAKKALLIGINYPGTAVELRGCVNDVHRMQKCLIELYGFANKDIVIMIDTDKSCIQPTGKNICDELDNLIASGQSGDFLVFHYSGHGTRIPPGIEDSEDPTGFDECITPCDMNLIKDQQFREMVSRVKEGCQLTIISDSCHSGGLIQEVKEQIGESHMKPVDKVKEQIEESHMKQPKLGIASYFLNIVMNLLATCGVSKSQRDRGGGEESFRGEIELEKDETLDIKTRYLPFESYLSLLKEQTGQTNIEPVRIRQTLLKLFGEDPSPNRQRGLSDLGNCEVDAGDSGASRLNAVTDNGILLSGCQTDQRSEDVYVTRTGKAYGAFSDAIQMILSAPRKDKKKITNKELVSEARVFLKKRGYSQRPGLYCHDRFVDKPFICY
Protein: Centromere/kinetochore protein zw10 homolog (Q19642)
Organism: Caenorhabditis elegans
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules. The recruitment of spdl-1 to kinetochores relieves this inhibition. Required for embryonic development.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18765790, ECO:0000269|PubMed:18936247}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O43264}. Note=Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition. Localization of the RZZ complex to kinetochores is dependent upon knl-1. {ECO:0000269|PubMed:18765790}.
Interaction partners:
- Protein zwilch homolog
- Kinetochore-associated protein rod-1
- Neuroblastoma-amplified sequence
- t-SNARE coiled-coil homology domain-containing protein
- Vesicle transport protein USE1
- Vesicle-trafficking protein SEC22b
- MAD related
- Mitotic checkpoint protein bub-3
- Coatomer subunit alpha
- Probable coatomer subunit delta
Sequence:
MASSEGSYRDLEKKLKNGLTSISQDIVDKYGNLKVSLNVNATAKLIFDRLENLEDIAEMSTRNLSNLIDQTAKDSPEMLAEIKSQAQSCENLVEFLQSMKNVEEQLIIMRSKTTNRVEWGTAILACKDFLNDTNMLLEGIGRDGFDMSVPLKHFAAEYSVLSYNCRYQLSADYERAMNVPKLSKQKCGDRTNVSFSVFNVGSVEDQKMLNETLSAMNMIGQLPERLDAWKIVILNVFCEAIVASRDGVDVYIVDNPTPDQTRFLINQKPRGKKDKTIDVAKVLESMEVFFTKLHSVLHSHELLDATGKTFTSMIGSVIEEQLITMILKDVIAIAAPVTETADEDQEMFINLLQIGEVFVERMKELGFFSQKAKLLFTLDTDTIFVTRRCFAIVSKANKLINETYDKLVTVGVDDSAIKDIDLLAKAHTHAEHFAKEYGKDLGRLWSHNEDSQFPSFFAFQKCTVSESTINFVNLLRDNVKAAFACEDEGARAKLALTAENIVRLYVILTPRKHAELFSSIPNMAAIFYNNCHYISHCIMTMSFEASGDNQKTLLEPLLLDSVIRLRTVAADCMEKTLTRCRREMTAYLEDHSIFEHLPASYKTTKNTFAAAEEMSESADILVPREEPKIIKCLAACLLHIRLIAKNLREPLTEVVYCKVIGSLVSFLLDSLVRHVVTTSDFRENDANVMADVFKRLLEVVANIVAYKEQTKVTDFCAREYFRLNEIVFVLGNRMQDIEHRWFNAKGPMAEHLSRSEVVGLIKALFADSQHRSDLIARL
Protein: Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) (Q9QXK7)
Organism: Mus musculus (Mouse)
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3' endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1. Required for entering/progressing through S-phase of the cell cycle (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UKF6}.
Interaction partners:
- Cleavage and polyadenylation specificity factor subunit 4
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 1
- Symplekin
- pre-mRNA 3' end processing protein WDR33
- Cleavage stimulation factor subunit 2
- WD repeat-containing protein 82
- Pre-mRNA 3'-end-processing factor FIP1
- Pre-mRNA cleavage complex 2 protein Pcf11
- E3 ubiquitin-protein ligase RBBP6
Sequence:
MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMIQNGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFYLLYYQLQKLTGDVEELEIQEKPALKVFKSITVVQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEVMLQDIFGEDCVSVKDDSVLSVTVDGKTANINLETRAVECEEGSEDDESLREMVELAAQRLYEALTPVH
Protein: Ras homolog family member Gb (Ras homolog gene family, member Gb) (Rhogb protein) (Q803F2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Engulfment and Cell motility 1
- Si:dkey-56f14.7.
- Engulfment and cell motility 2.
- Intersectin 1
- Guanine nucleotide exchange factor VAV2 isoform X3
- Dedicator of cytokinesis protein 4 isoform X1
- Rho GDP dissociation inhibitor
- Rho GDP dissociation inhibitor
- Intersectin-2b
- Intersectin 2a.
Sequence:
MQSIKCVVVGDGAVGKTCLLISYTTGAFPKEYIPTVFDNYSSQVSVDNRTVSLNLWDTAGQEEYDRLRTLSYPQTNVFIICFSISSPPSYENIKHKWHPEVTHHCPSVPILLVGTKSDLRNDADVLKKLKEQNQAPITTQQGQALARQIHAVKYRECSALSQDGIKDVFADAVRAYLSPQPVANKKPCILL
Protein: CUGBP Elav-like family member 1 (Q8IDB7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MDDHENIDINDNSSDANTANYNQDKNENTSEVNDYSKEDIEGDENLKSSKGKQENNTKSSSDKDENTIDYGNHDFPCNPAPPVPIKLFIGRVPKNIEEDQLRPIFEEYGIVNEVVIIRDKITNVHKSSAFVKMASISEADNAIRLLNNQKTLDAQLGSLQVKYASGELNKLGFPQNIESGVDQAKLFIGSLPKNITEDNIKEMFSPYGTVEEVFIMKDNSTGLGKGCSFVKFSYKEQALYAIKSLNGKKTLEGCTRPVEVRFAEPKSSKQPQIPLTLQPMQNPPHAMAPQPSISSPNNINFGNNFSVNNNYPRQVGPWKEYYSGEGRPYYYNEQTNTTQWEMPKEFETLFMNNSANMHNLSESSGPPGANLFIFHVPNEWQQTDLIQAFSPFGELLSARIATEKNTGRNRGFAFVSYDSLESAAAAISQMNGFMALNKKLKVTVKKGEEDEMKKYVNQNGVNSFQQVPRVQKAIPAQPASMQPNLAYHQNPQAQNFFYSNSNSYRCGPY