wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q581C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MPLWKQTNCEVETMNVREVVGTVHLGYVSQMLLLVATVATIVVRSGAAPIELKRHVTTVAGKYGHIGDKDGFPGMSELSSPHAMCRGRNSDEILLGTVDRFRAFSRKNRETTTITAWETDEDQKSGSRSVKVDKPRACVQWTVGGSTFVYFVESMGEVKYFKDSGVFSHDVVRNGSLTGVALYGNHLYLTEQNTNTVWTCEVGSDGDPIACHSHVALSANCSIYGPIGIAATQQGIFVVARGPAKQGTICWFDLQGHKIAEVDGEYVDITSTRSGDLLAATQNELHRVSTDGNKLTTKRFAGGSTNSCLPNTEGDDTLLCEITRLLVVTEYEMYVTSEKKSVLRSVTLPPVYVQGLFPGRPLPVGYPDKDIMEWIVGNLTEDINTALGTTESIVASSSVHVDSTTWLTNFTAGVQQPDFDDEKTEQALHESNYEHTKEAADEYYNLTDEQVYMDSTMVPYCNRLSLDALRRKLAKEAGEVLNFTLIYADMPLKAESSDAENITTVKLLMPASFNNTVTHDLLSDANLTETAHSFIKYLRSSDTHVDVTFSNPPFNFSSLTPDEEQEVRWYIHDEVMNQIKKCEERSTGRSMARREEVGDHSRTTIATALDSNVTGVCQSTITNRTVSLFYQPPYVEMSLYEVFIPGNYTFDVSECVGEIDWQDLNDHLNNDTVRPTTEKAPKCGRVCLIIIAVVCALIVAVLIVLAVVFTSKRRRLAAVVAPARPKFVSTLDEDEQDYASAYGNKERVEQ
Protein: UPF0651 protein P31B10.02, mitochondrial (Q9USH2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- NADH-ubiquinone oxidoreductase 24 kDa subunit homolog C11E3.12, mitochondrial
- NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial
Sequence:
MHLTLFKELLKQPKPKFHFEIEPNVSFLAVEEGPASLRSYSIGNVSRIYDGIRVPPKPEEPLNCCQSGCAICVWDVYADDLEEYNRARRKAKRHYLDKHLPVPPDLAKVSLKETSSLEELPPQLKAFVLLEKRLMKDKQSKNN
Protein: Serine/threonine-protein kinase BRI1-like 2 (EC 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) (Q9ZPS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor with a serine/threonine-protein kinase activity, which may transduce extracellular spatial and temporal signals into downstream cell differentiation responses in provascular and procambial cells. In contrast to BRI1, BRL1 and BRL3, it does not bind brassinolide.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15486337}; Single-pass type I membrane protein {ECO:0000269|PubMed:15486337}.
Interaction partners:
- Inactive TPR repeat-containing thioredoxin TTL3
- GDSL esterase/lipase APG
- BSD domain-containing protein
- Serine/threonine-protein phosphatase BSU1
Sequence:
MTTSPIRVRIRTRIQISFIFLLTHLSQSSSSDQSSLKTDSLSLLSFKTMIQDDPNNILSNWSPRKSPCQFSGVTCLGGRVTEINLSGSGLSGIVSFNAFTSLDSLSVLKLSENFFVLNSTSLLLLPLTLTHLELSSSGLIGTLPENFFSKYSNLISITLSYNNFTGKLPNDLFLSSKKLQTLDLSYNNITGPISGLTIPLSSCVSMTYLDFSGNSISGYISDSLINCTNLKSLNLSYNNFDGQIPKSFGELKLLQSLDLSHNRLTGWIPPEIGDTCRSLQNLRLSYNNFTGVIPESLSSCSWLQSLDLSNNNISGPFPNTILRSFGSLQILLLSNNLISGDFPTSISACKSLRIADFSSNRFSGVIPPDLCPGAASLEELRLPDNLVTGEIPPAISQCSELRTIDLSLNYLNGTIPPEIGNLQKLEQFIAWYNNIAGEIPPEIGKLQNLKDLILNNNQLTGEIPPEFFNCSNIEWVSFTSNRLTGEVPKDFGILSRLAVLQLGNNNFTGEIPPELGKCTTLVWLDLNTNHLTGEIPPRLGRQPGSKALSGLLSGNTMAFVRNVGNSCKGVGGLVEFSGIRPERLLQIPSLKSCDFTRMYSGPILSLFTRYQTIEYLDLSYNQLRGKIPDEIGEMIALQVLELSHNQLSGEIPFTIGQLKNLGVFDASDNRLQGQIPESFSNLSFLVQIDLSNNELTGPIPQRGQLSTLPATQYANNPGLCGVPLPECKNGNNQLPAGTEEGKRAKHGTRAASWANSIVLGVLISAASVCILIVWAIAVRARRRDADDAKMLHSLQAVNSATTWKIEKEKEPLSINVATFQRQLRKLKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDKEEFGDTNLVGWSKMKAREGKHMEVIDEDLLKEGSSESLNEKEGFEGGVIVKEMLRYLEIALRCVDDFPSKRPNMLQVVASLRELRGSENNSHSHSNSL
Protein: Proteasome subunit beta type-5 (EC 3.4.25.1) (Q54BC8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-2
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-7
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-3
Sequence:
MINIDFDNIEQSQPTLYDTLASDVKFLNTPHFELPPNANPGDFLRETFDHPSAPKALEFAHGTTTLAFVYGGGIIVSVDSKSTQGPYVASRSVKKVIEITPTLLGTMAGGAADCSFWERELGRRCRLYELRNKELISVAAASKILANIVYSYKGYGLSMGTMITGWDKTGPQLYYVDNDGTRLHGQRFSCGSGSTYAYGVLDTGFKWDMNDEEAYELGRRAVYHATHRDAYSGGAINVYHVQKDGWKKISSDDCFKLYQKYYNIVPINKPAN
Protein: Stabilizer of axonemal microtubules 2 (Q8BQB6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Cilia- and flagella-associated protein 161
- Radial spoke head 14 homolog
Sequence:
MRNWCLCQICTCGSDYRPYEIVKQPRHIPEEYKPKQGKIDLGTTYKRDFNPYKVQPLIKVRPVERQQVKKGKLDTVPTYKDDYRSWDIQKCELCKPEQAYHPPDVKFGNSTTFQDDYVPQEIKPRQSFKPCSVVKCSVGPFNGDTSHRRDYVPHQLEVKFARPKEIYKPTDQPFEDLTTHRNDFQGLAGETAKICRPAYTRVTQNIQFKGSTEFRDSFQPWEIPPPKVKKVAEYVPPSGSMQLNSTSHLDYVPYQASRVVAIRPVSHRRQSNFPFQGKSTTKEDFPAWEICRQGLIKQQQQIPNPSGKFEGLSTFRSHFVPHELIPTESCKPLNEALKSSVPLDDVTMYSIQFTPKKQEICPASYPSPPGYIFENTNSQGHKFFRKIIPAVKAF
Protein: Uncharacterized protein C1494.08c (O60082)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein C14G10.04
- Uncharacterized protein C16C6.04
- Meiotically up-regulated gene 113 protein
- Uncharacterized protein C56F8.02
- Peptidyl-prolyl cis-trans isomerase B
- Uncharacterized protein C9G1.07
- Ceramide-binding protein svf1
- U6 snRNA phosphodiesterase 1
Sequence:
MSIFIPKARRPTFELHLRIHDVVNIPLITGVIFVKWNIEGIHSRHANDQTEAEPVLEHRVTWEYETCVSVRMIIDNDNLLKDKFLILQVLCDSHTDSGVIRLGILKINLTEYVYVGQDTRKYLLADSKINATIRIGISLKQTSGNKDFRVSKTLGKPQVFSGLTGLLTDGKELKRRDDEVYTSTGLASAWAEKMLHSIKDFNQKTTVFHMHTRNNKYDTREIVDDIFFGGTGWAEPPKIADIVDAAGDTDLISLEIRQKSWVLPSEKVLNKRLP
Protein: Tyrosine decarboxylase (Q57X14)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRHTVKLCGALQHLLDHSTRFINNLIFLAGDHASAETTPTDRHTASRGSSVQTQGAAENWHQTQYVHAAEVIRNAAARDYLLDSESDTAELHASLVTALMRGTRWGSTISQDTDMLLINELERDVADRVARMFLLPSRFMWRSCHQAVPNGGRGNQCKCNVLVVPKRSSDLSNVRHHVSSGDADSGGGGGIMHSSSLESLIVLMKTAKAQARARYLSSRFSCPDDESRMSQRLVLYCSDQSDKLLLQAARCTGVQHVRTLQTVYSPKVHNYPMQVDMLKAALAEDVSHGFYPLLVCGVFGSHVAASVDPLQEMAELCQKLKLWFHIDASHSGLALAAGAASVTMPQDTTVASSMEKKAEVVMTKDTVWEEYMHSFNQAATLADSVHFGVSSSFLPTAASASSTALLYVSNVAKVDAALRHLNRSAESSVNAWCASSRAQQMSQMLQLRLEPQHVHANEIIRLSLILHQMDDAYVSKRVRDHQAAMYHLQQRIRADGRFDCSVHASCFGMVLFRWLLLADEETEALMWRWDELLKAQRVSSNFGEGIRPFLGLVRIQRRLHICVGFVGAVGGGKSCCAPSLSQRDVNTLVDSLTEAASFGRNKGRVV
Protein: Ras-related protein Rab-19 (EC 3.6.5.2) (A4D1S5)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
Sequence:
MHFSSSARAADENFDYLFKIILIGDSNVGKTCVVQHFKSGVYTETQQNTIGVDFTVRSLDIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESIPHWIHEIEKYGAANVVIMLIGNKCDLWEKRHVLFEDACTLAEKYGLLAVLETSAKESKNIEEVFVLMAKELIARNSLHLYGESALNGLPLDSSPVLMAQGPSEKTHCTC
Protein: Protein RETARDED ROOT GROWTH-LIKE (Q9FNB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates abscisic acid (ABA) signal transduction through mitochondrial retrograde regulation involving ABI4 during seed germination and seedling growth, and leading to the production of reactive oxygen species (ROS) by the alternative respiratory pathway. Required for the maintenance of mitochondrial structure.
Subcellular location: Mitochondrion membrane {ECO:0000305|PubMed:26163700}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:26163700}.
Interaction partners:
- Protein DGS1, mitochondrial
Sequence:
MMRSVDVYVKTLGPPVRSILYSIFTSQQKPSSLPSLPFHFSLRSSSNIPTRCFSNVVAKSNSPIYDFQGFRNLFTERAISSSTTTPVASAQPQQLQNQNQHPAEVDEEISMGLEDEAKLSIPVRAYFFSTSVDLRSLIEQNKQNFIPPTSRMTNYVVLKFGNHSDPTDTTRGRISGSESIYMVVFHYGSIVLFNVREHEVDEYLKVVERHASGLLPEMRKDEYEVRENPNLDTWMEVGRDFIRLQFLNTDGIRTIGCVLGQSIALDYYGRQVDGMVAEFTEINRQLEITGTFTMKRKKLFQLVGKANVILADVILKLGLFERSDIAWKDAKYGQIWEFLRDEFELTQSFANLDYKLKFVEHNVRFLQEILQNRKSATLEWLIIILISMEIAISFYNMSRASL
Protein: Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) (Q86SK9)
Organism: Homo sapiens (Human)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Inter-alpha-trypsin inhibitor heavy chain H4
- Very long chain fatty acid elongase 6
- Stearoyl-CoA desaturase
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain
- Very-long-chain
- Very-long-chain
- Very-long-chain enoyl-CoA reductase
- Very-long-chain
- Glycerol-3-phosphate acyltransferase 1, mitochondrial
Sequence:
MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA
Protein: Mediator of RNA polymerase II transcription subunit 28 (Mediator complex subunit 28) (Q920D3)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=May be also cytoplasmic and membrane-associated. {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 18
Sequence:
MAASLGGMFTGQPPGPPPPPPGLPGQASLLQAAPGAPRPSNSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPDQVIKEDVSELRSELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADMPQGSLAFLEQASANIPAPLKQT
Protein: Phosphoprotein (Protein P) (P03421)
Organism: Human respiratory syncytial virus A (strain A2)
Function: Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins. Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex. Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA. Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs. Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription. Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (By similarity).
Subcellular location: Virion {ECO:0000269|PubMed:27654298}. Host cytoplasm {ECO:0000269|PubMed:27654298}. Note=Localizes in cytoplasmic inclusion bodies. {ECO:0000269|PubMed:27654298}.
Interaction partners:
Sequence:
MEKFAPEFHGEDANNRATKFLESIKGKFTSPKDPKKKDSIISVNSIDIEVTKESPITSNSTIINPTNETDDTAGNKPNYQRKPLVSFKEDPTPSDNPFSKLYKETIETFDNNEEESSYSYEEINDQTNDNITARLDRIDEKLSEILGMLHTLVVASAGPTSARDGIRDAMIGLREEMIEKIRTEALMTNDRLEAMARLRNEESEKMAKDTSDEVSLNPTSEKLNNLLEGNDSDNDLSLEDF
Protein: Probable F-box protein At1g65740 (Q9SHY1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- mRNA-decapping enzyme-like protein
- Putative ribonuclease H protein At1g65750
- mRNA-decapping enzyme subunit 2
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- Putative F-box protein At5g55150
- Uncharacterized protein At4g25920
- Putative F-box protein At4g22180
- Probable F-box protein At4g22030
- At1g30160
- F-box protein At2g16300
Sequence:
MVDWSTLPEELLHFIAARSFSLVEYKRFSSICVSWHSSVSGVKKNPFHRRPLIDFNPIAPSETLLEDHVFSCNPGAFLSRAAFFRVTLSSSPSKGWIIKSDMDTNSGRFHLLNPLSRFPLRISSESLDLLDFTVSEIQESYAVLKDAKGRLPNPGYQRSALVKVKEGDDHHHGILGIGRDGTINYWNGNVLNGFKQMGHHFSDIIVHKGVTYVLDSKGIVWCINSDLEMSRYETSLDENMTNGCRRYYMRFVDCCGELYVIKRLPKENSRKRKSTLFQFSRTAGFKVYKIDKELAKWVEVKTLGDNAFVMATDTCFSVLAHEYYGCLPNSIYFIEDLEPKVFQLDNGNGSSITRKSESSESSFEMFFPSFL
Protein: Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) (P29122)
Organism: Homo sapiens (Human)
Function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
Subcellular location: [Isoform PACE4A-I]: Secreted.; SUBCELLULAR LOCATION: [Isoform PACE4A-II]: Secreted.; SUBCELLULAR LOCATION: [Isoform PACE4C]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform PACE4CS]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform PACE4E-I]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; SUBCELLULAR LOCATION: [Isoform PACE4E-II]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; SUBCELLULAR LOCATION: [Isoform PACE4B]: Secreted.
Interaction partners:
- Nodal homolog
- Membrane-bound transcription factor site-1 protease
- Steroid hormone receptor ERR2
Sequence:
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
Protein: Protein ilm1 (Q9P7H7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLFSFRAIVLFYCCMLTFAGIGFLWNPKFVVESGLVALIGASMEVKPLIVTQDNLSTLALSGLVFLILGMIYTISLLQSNFLFFSGITPIRAIFDFILTGFIYLKKEHIASNSLTFTFAFCDLMWQFWMFAAMSEERAKYLKNQKKAEELAARKAREVEES
Protein: Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) (O95361)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27693506}.
Interaction partners:
- Galectin-3
- Vesicle-trafficking protein SEC22b
- Autophagy-related protein 16-1
- Galectin-8
- Gamma-butyrobetaine dioxygenase
- Beclin-1
- Tripartite motif-containing protein 16-like protein
Sequence:
MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP
Protein: Zinc finger, MYND-type containing 10 (Q384J6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 140
- Uncharacterized protein
- VASt domain-containing protein
Sequence:
MEFSGSTLSVVEVEHTVRQLRPFPLQDIGTAEWKNQREAVERLNMCTHSNAVLKKDDTVKAFLIEHEKLPVLLHELLVMEVWRQRVLPLIKDQIVQHPAGIYMYVQYEMVLLNLFECIAFHEEVVVALDEDVLELIDYCWRQASRLFAEQNVNEVQSKPTARDVSNAANTVEEVLKSADRQMLHAIYQRAMASLSILWFIIDRLNQLPLAASNSVLVKNDLILGLTEVMLLQPWLRRSSEATQKFFNGEFKDIPRADVLLVCTPEAHTWFSLHKLLCDPECRRRYSYTQSKKELILRIRHFLNDTLVDQIPALASLQRALEELSFLQPPSGTEEKFKSTLTIEQVPRIMTLVEVERKGSWDDLASTLRAMLQDPSVRNEDAMRLSRIFDEMFSDQLK
Protein: Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) (P10901)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Interaction partners:
- alpha-L-fucosidase
- Uncharacterized protein
- Probable serine/threonine-protein kinase pXi
- Putative lysozyme-like protein
Sequence:
MKMIIIFFILLILNLIKSQQYGPTWDQINSRPLPGWYDDVKFGIFIHFGIYSVPAFANGGYAEWYWWTLKNPSSDGGATQRYHEKEFGANFTYQDFVSRFDCRLFDANEWASIIEKSGAKYVVLTSKHHEGYTLWNSEQSWNWNSVETGPGIDIVGELTKSVKNMGLHMGLYHSLFEWFNPLYLADAETGKNPTTQVYVDEILMKQLKDIVTTYEPELIWADGDWMQLSNYWKSTEFLSWLYTNSSVKDTVIVNDRWGSECRDKNGGFYTGADHFNPYKLQSHKWENCATIGYSYGYDEYEQATDYQNATELIIDLVTTVACGGNFLLDVGPDAQGTIPNNMVDRLLEIGNWLSINSESIYGSSPWRVQNMTFNIWYTTNTTNGNVYAFVFELPDDGVLILSDPIGNNKTEATLLGLKGEKGVEVSLPIESTKPGITLNIPMVAPQDYPPYVYVFRLTDVE
Protein: Tartan, isoform B (M9PFH7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Epidermal stripes and patches, isoform A
- Zinc carboxypeptidase A 1
- Ventrally expressed gene D protein
Sequence:
MQRNMMIAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMISEKKLNNNKALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATATVGDSCYSYADVPMVHGAPLGGPNQPQLRLTQEHFKQRELYDQEMGSEILDHNYIYSNTHYSMPLEQLGRSKTPTPPPMPPALPLRNGLCATTGRRSFQQKSASQKQQQNNNTLRQFTHXSSTYRRRQLSIYA
Protein: Integration host factor subunit alpha (Q72F19)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Integration host factor, beta subunit
- Viral histone-like protein
- DNA-binding protein HU, beta subunit, putative
- Transcriptional regulator, MerR family
- Acyl carrier protein
- HIT family protein
- Translational regulator CsrA
- DNA-binding protein HU
Sequence:
MSKTLTKAEIVDAIYEKTDRNRAEVKGVVESLLGIMKQAIKKDHALLISGFGKFEAYDKKARKGRNPQTDETITLPPRKVVVFRLSRKFRAELNE
Protein: Protein YjdM (P0AFJ1)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Protein YjdN
- Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH
- Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase
- Phosphonates-binding periplasmic protein
- Putative phosphonates utilization ATP-binding protein PhnK
- Phosphonates import ATP-binding protein PhnC
Sequence:
MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVKDANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLKSEFVKKN
Protein: BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) (Q6AI39)
Organism: Homo sapiens (Human)
Function: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
Interaction partners:
- Bromodomain-containing protein 9
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- B-cell CLL/lymphoma 7 protein family member C
- B-cell CLL/lymphoma 7 protein family member A
- Actin-like protein 6A
- BRD4-interacting chromatin-remodeling complex-associated protein
- SWI/SNF complex subunit SMARCC1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- B-cell CLL/lymphoma 7 protein family member B
Sequence:
MDDDDDSCLLDLIGDPQALNYFLHGPSNKSSNDDLTNAGYSAANSNSIFANSSNADPKSSLKGVSNQLGEGPSDGLPLSSSLQFLEDELESSPLPDLTEDQPFDILQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSGQTLQPIGVTHVPVGASFASNTVGVQHGFMQHVGISVPSQHLSNSSQISGSGQIQLIGSFGNHPSMMTINNLDGSQIILKGSGQQAPSNVSGGLLVHRQTPNGNSLFGNSSSSPVAQPVTVPFNSTNFQTSLPVHNIIIQRGLAPNSNKVPINIQPKPIQMGQQNTYNVNNLGIQQHHVQQGISFASASSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSSTGGSIVIHSPMGQPHAPQSQFLIPTSLSVSSNSVHHVQTINGQLLQTQPSQLISGQVASEHVMLNRNSSNMLRTNQPYTGPMLNNQNTAVHLVSGQTFAASGSPVIANHASPQLVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPSVTSMSGPSRFPAVSSASTAHPSLGSAVQSGSSGSNFTGDQLTQPNRTPVPVSVSHRLPVSSSKSTSTFSNTPGTGTQQQFFCQAQKKCLNQTSPISAPKTTDGLRQAQIPGLLSTTLPGQDSGSKVISASLGTAQPQQEKVVGSSPGHPAVQVESHSGGQKRPAAKQLTKGAFILQQLQRDQAHTVTPDKSHFRSLSDAVQRLLSYHVCQGSMPTEEDLRKVDNEFETVATQLLKRTQAMLNKYRCLLLEDAMRINPSAEMVMIDRMFNQEERASLSRDKRLALVDPEGFQADFCCSFKLDKAAHETQFGRSDQHGSKASSSLQPPAKAQGRDRAKTGVTEPMNHDQFHLVPNHIVVSAEGNISKKTECLGRALKFDKVGLVQYQSTSEEKASRREPLKASQCSPGPEGHRKTSSRSDHGTESKLSSILADSHLEMTCNNSFQDKSLRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLETTFKNILELKKAGRQPQSDPTVSGSVELDFPNFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC