Protein: Mitogen-activated protein kinase kinase kinase dlk-1 (EC 2.7.11.25) (DAP kinase-like kinase) (Death-associated protein kinase-like kinase) (O01700)
Organism: Caenorhabditis elegans
Function: Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4. Has a role in axonal regrowth following injury and synaptogenesis. Plays a role in modulating polymerization of neuronal microtubules. Also promotes tubulin post-translational modifications that protect microtubules. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis, and may also have a role in intraflagellar transport in cilia. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
Subcellular location: Synapse {ECO:0000269|PubMed:15707898, ECO:0000269|PubMed:18224716, ECO:0000269|PubMed:23000142}. Cytoplasm {ECO:0000269|PubMed:26657059}. Cell projection, axon {ECO:0000269|PubMed:26657059}. Cell projection, dendrite {ECO:0000269|PubMed:26657059}. Cell projection, cilium {ECO:0000269|PubMed:26657059}. Note=Observed in the periactive zone of the presynaptic terminal which surrounds the synaptic vesicle clusters and active zones. {ECO:0000269|PubMed:15707898}.; SUBCELLULAR LOCATION: [Isoform a]: Synapse {ECO:0000269|PubMed:23141066}. Cell projection, axon {ECO:0000269|PubMed:23141066}. Note=Co-localizes with isoform c in synapses and axons; however, isoform a localization is independent on its interaction with isoform c. During axonal injury, recruited to the injured site. {ECO:0000269|PubMed:23141066}.; SUBCELLULAR LOCATION: [Isoform c]: Synapse {ECO:0000269|PubMed:23141066}. Cell projection, axon {ECO:0000269|PubMed:23141066}. Note=Co-localizes with isoform c in synapses and axons; however, localization is dependent of its interaction with isoform a. {ECO:0000269|PubMed:23141066}.
Interaction partners:
- E3 ubiquitin-protein ligase rpm-1
- Dual specificity mitogen-activated protein kinase kinase mek-1
- PHR domain-containing protein
- Cell death protein 3
- CCAAT/enhancer-binding protein homolog 1
- F-box/SPRY domain-containing protein 1
- X-linked retinitis pigmentosa GTPase regulator homolog
- Tyrosine-protein phosphatase vhp-1
Sequence:
MTSTTMVTTLDLVTPTSEEQPGPAPESSDFSTVVLSPDGSELVTQSAPNTPIQHREQANAEFGQKEGSPDPKNMVAATGNASKPSLNSFYADGLGQLRNGLFSCFQPVFGYFGTKTTVEIEKSEDELWEIPFDAISELEWLGSGSQGAVFRGQLENRTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHWEIFKPELFEMTEEEWQLAWDSYREFAKCIQYPSTVTRDHGGPKSAFAMEEEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGCFTELKLKESELAEWEKDLTEREQWHNQNSPKAVAAPRAQLRGYPNEGYDDMSSDEDVQPCRGSPYRCSNTSSSSGVQSSPFSRQSSSRSSAGQQTRRSEGANPPKILRNDAIRHSGSYWETLGGARGSPARDSGFSQDSGMWSAGAGSCTAINGGGQQVCYSQTLYRNGDGRWSDGRIASRRRVSTSVNKSTAVPGQPVFFTRDSPSRVPHGVISCSSPRSSSKLNRSSYPSRNAPHQLEDGCCCAHARAPRAKSIAVPMTSSSRARSPTPYDNDFENAESFVDPESPKNLKNLEKIVNLPESTSYDEALCNSDVTMNPIYTSPITTYSNPCHVELVDEENANDVDLTSSMDSRRSRSDDADVESSEEDEGNGNNILNTSMESEDLRYRIDTSQSTMMSSLERSLEIGATRSDGLSDNEMRVQAVKMSIKTHRRTGSNPQALIHQCIDEYTTSATDDSDDAGAVRI