wanglab/gogpt-training-data huggingface dataset:
Protein: Casein kinase 1-like protein 10 (EC 2.7.11.1) (Protein CASEIN KINASE I-LIKE 10) (Q9LW62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P48730}. Cell junction, plasmodesma {ECO:0000269|PubMed:16126836}. Note=Present in punctate particles with granular structure. {ECO:0000269|PubMed:16126836}.
Interaction partners:
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- At5g26610
- Protein FIP2
- Cytochrome P450, family 702, subfamily A, polypeptide 8
- At3g49990
- At3g16760
- DExH-box ATP-dependent RNA helicase DExH14
- Nuclear pore complex protein NUP35
- Protein phosphatase inhibitor 2
Sequence:
MDHVIGGKFKLGRKIGSGSFGELYIGINVQTGEEVALKLEPVKTKHPQLHYESKVYMLLQGGTGVPHIKWFGVEGNYNCMAIDLLGPSLEDLFNYCTRSFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFIRGSLPWQGLKAGTKKQKYEKISEKKMLTPVEVLCKSYPSEFTSYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDWTILKYPQSGSISKPRPNPKPALDPPGPSAERNEKPIVGQDLRERFSGAVEAFARRNVPSHGIRPKHIFSDDASKEVQVSEKTRNEIATKMAVMSSSQPGSSGELSENRSSKLFSSSAQKIQPVQETKLSARLGRDDGLRSFDMLTIGSGKRK
Protein: Citrate synthase (A2R4X3)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MSFSMPIRPTTRHASRLAQAKIRSGRLYSTESDLKTALKSVIPEKRELFKQVKARSDDVVGEVKVGNIIGGMRGLKSMLWEGSVLDPEEGIRFHGKTIKDCQRELPKGTTGTEMLPEAMFWLLLTGQVPTTSQVRAFSRELAEKSHLPDHILGLIKLFPKDMHPMTQLSVAVAALNTESTFAKAYERGLNKADYWEPTFDDSISLLAKIPRVAALVFRSNEIDQVGTQALDATQDWSHNFAELLGKGGAEHADFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQEKIGTQVTDDSVRTYLWDTLKSGRVVPGYGHGVLRKPDPRFEALMDFAATRPDVQANPVFQLVKKNSEIAPEVLTQHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLKGLIGN
Protein: Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) (Mitofusin-binding protein) (Protein MIB) (Q3MIE4)
Organism: Rattus norvegicus (Rat)
Function: Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. May negatively regulate mitochondrial fusion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17105775}. Mitochondrion outer membrane {ECO:0000269|PubMed:17105775}; Peripheral membrane protein {ECO:0000269|PubMed:17105775}. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria.
Interaction partners:
Sequence:
MSAEREATEAATVAAAAEARAETGAGEGAPSQPPTVEVASDPQPPPAPEASASASAPPLRCLVLTGFGGYDKVKLQSRPAVPPAPGPGQVTLRVRACGLNFADLMGRQGLYDRLPPLPVTPGMEGAGVVVAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSAQTFLMPEAMTFEEAAALLVNYITAYMVLFDFGNLRPGHSVLVHMAAGGVGMAALQLCRTVENVTVFGTASASKHEVLKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYHLLKPMGKVVTYGMANLLTGPKRNLMAMARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSRVVTHLLALYNQGHIKPRIDSVWPFEKVADAMRQMQEKKNIGKVLLVPGPEKET
Protein: Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) (D3ZBE5)
Organism: Rattus norvegicus (Rat)
Function: Protein kinase which plays an important role in mitotic cell cycle progression (By similarity). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (By similarity). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Phosphorylates RPS6KB1. Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (By similarity). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (By similarity). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8TDX7}. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q8TDX7}.
Interaction partners:
- NACHT, LRR and PYD domains-containing protein 3
- Serine/threonine-protein kinase Nek9
- Caspase-1
- Ankyrin repeat and SAM domain-containing protein 3
- Ankyrin repeat and SAM domain-containing protein 6
- Gasdermin D
- Interleukin-1 beta
Sequence:
MDEQPQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYDVAKRMHACTASS
Protein: Photosystem II reaction center protein K (PSII-K) (P0C408)
Organism: Oryza sativa (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00441}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00441}.
Interaction partners:
Sequence:
MPNILSLTCICFNSVIYPTSFFFAKLPEAYAIFNPIVDFMPVIPVLFFLLAFVWQAAVSFR
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q6FSC9)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Nucleoporin NSP1
- FK506-binding protein 2
- FK506-binding protein 1
- Candida glabrata strain CBS138 chromosome C complete sequence
- rRNA 2'-O-methyltransferase fibrillarin
Sequence:
MKLNIIWTLCLLFGIVSAAVKPEVTHKVYFDIEHDGVSKGRIVIGLYGKIVPKTVENFYELSISDDSNMGYLGSIFHRVIPQFMIQGGDFTHGTGIGGKSIYGSTFPDENFDLKHDRPGLLSMANRGKDTNGSQFFITTVATPWLDGRHVVFGEVLEGMDVVTYIENVKTNAQNRPLKDVVIADSGELETAPLGNKPRDVPDDEL
Protein: Integrin alpha-D (CD antigen CD11d) (Q9QYE7)
Organism: Rattus norvegicus (Rat)
Function: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Integrin beta
- Intercellular adhesion molecule 1
- Vascular cell adhesion protein 1
- Thy-1 membrane glycoprotein
- Low affinity immunoglobulin gamma Fc region receptor III
- Integrin subunit alpha L
- Integrin beta-1
- Receptor-type tyrosine-protein phosphatase C
- T-cell surface glycoprotein CD4
- CD19 molecule
Sequence:
MAGGVVILLCGWVLASCHGSNLDVEEPIVFREDAASFGQTVVQFGGSRLVVGAPLEAVAVNQTGRLYDCAPATGMCQPIVLRSPLEAVNMSLGLSLVTATNNAQLLACGPTAQRACVKNMYAKGSCLLLGSSLQFIQAVPASMPECPRQEMDIAFLIDGSGSINQRDFAQMKDFVKALMGEFASTSTLFSLMQYSNILKTHFTFTEFKNILDPQSLVDPIVQLQGLTYTATGIRTVMEELFHSKNGSRKSAKKILLVITDGQKYRDPLEYSDVIPAADKAGIIRYAIGVGDAFQEPTALKELNTIGSAPPQDHVFKVGNFAALRSIQRQLQEKIFAIEGTQSRSSSSFQHEMSQEGFSSALTSDGPVLGAVGSFSWSGGAFLYPPNTRPTFINMSQENVDMRDSYLGYSTAVAFWKGVHSLILGAPRHQHTGKVVIFTQEARHWRPKSEVRGTQIGSYFGASLCSVDVDRDGSTDLVLIGAPHYYEQTRGGQVSVFPVPGVRGRWQCEATLHGEQGHPWGRFGVALTVLGDVNGDNLADVAIGAPGEEESRGAVYIFHGASRLEIMPSPSQRVTGSQLSLRLQYFGQSLSGGQDLTQDGLVDLAVGAQGHVLLLRSLPLLKVELSIRFAPMEVAKAVYQCWERTPTVLEAGEATVCLTVHKGSPDLLGNVQGSVRYDLALDPGRLISRAIFDETKNCTLTGRKTLGLGDHCETVKLLLPDCVEDAVSPIILRLNFSLVRDSASPRNLHPVLAVGSQDHITASLPFEKNCKQELLCEGDLGISFNFSGLQVLVVGGSPELTVTVTVWNEGEDSYGTLVKFYYPAGLSYRRVTGTQQPHQYPLRLACEAEPAAQEDLRSSSCSINHPIFREGAKTTFMITFDVSYKAFLGDRLLLRAKASSENNKPDTNKTAFQLELPVKYTVYTLISRQEDSTNHVNFSSSHGGRRQEAAHRYRVNNLSPLKLAVRVNFWVPVLLNGVAVWDVTLSSPAQGVSCVSQMKPPQNPDFLTQIQRRSVLDCSIADCLHFRCDIPSLDIQDELDFILRGNLSFGWVSQTLQEKVLLVSEAEITFDTSVYSQLPGQEAFLRAQVETTLEEYVVYEPIFLVAGSSVGGLLLLALITVVLYKLGFFKRQYKEMLDGKAADPVTAGQADFGCETPPYLVS
Protein: Inversin (Inversion of embryo turning protein) (Nephrocystin-2) (O89019)
Organism: Mus musculus (Mouse)
Function: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle (By similarity). Membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium. Also nuclear and perinuclear. {ECO:0000250}.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Serine/threonine-protein kinase Nek8
- Nephrocystin-3
- Nephrocystin-1
- Nephrocystin-4
- Jouberin
- Ankyrin repeat and SAM domain-containing protein 6
- Centrosomal protein of 290 kDa
- IQ calmodulin-binding motif-containing protein 1
- Calmodulin-like protein 3
Sequence:
MNISEDVLSTGSSLASQVHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLPCPPSPQNEGSKQDATPSKQPPASHTVQSPDPEHSRLPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYEDICASPETGVAHGPPPGQCMNIHLLPVEQRLLIIQRERSRKELFRRKNKAAAVIQRAWRSYQLRKHLSRLLHLKQLGAREVLRCTQVCTALLLQVWRKELELKFPKSISVSRTSKSPSKGSSATKYARHSVLRQIYGCSQEGKGHHPIKSSKAPAVLHLSSVNSLQSIHLDNSGRSKKFSYNLQPSSQSKNKPKL
Protein: Type VI secretion protein (D3GUX6)
Organism: Escherichia coli O44:H18 (strain 042 / EAEC)
Interaction partners:
Sequence:
MPRPSLYEILYGNFTGGLELNQVGEEEQVILSVLDNMQRILNTRAGSLKHLPDYGLPDITTILQGMPGTAHQLMRVLSDVLLKYEPRIKRVDVTMQEQTQPGELHYVIDAELKDAGLVRYGTTFIPEGRVLLRHLKQQRYVQT
Protein: G-protein coupled receptor moody (Q9W534)
Organism: Drosophila melanogaster (Fruit fly)
Function: Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16213219}; Multi-pass membrane protein {ECO:0000269|PubMed:16213219}.
Interaction partners:
- GH05443p
- Sodium/potassium-transporting ATPase subunit beta-2
- Multidrug resistance protein homolog 65
- Guanine nucleotide-binding protein subunit beta-1
- G protein alpha i subunit subunit alpha 65A)
- Basigin, isoform G
Sequence:
MSDETTISLEDGYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCALVLPFQGLRFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHHGLYARIYKRHWIAVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSKTTLFITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVADKNVEHPSLHICSYILLYLSACINPIIYVIMNKQYRKAYKTVVFCQPARLLLPFGKTNGASSAAEKWKDTGLSNNHSRTIVSQMSGGTGAASGAGTATGTAAVAVMQTPPEVQQAQALEMVSRGPDLISKSNLPQPNVTPPPPSVLTATPNGSNSNSLTLRLPLKKNNHCYTNSGFNSSTPSPSSGLGIGISSSSIYRPGVGSLGSGSASIRRITMVGDDIILEEEELPPTPPATSAPTTPAPPPPSSPLHPLSTDSSTTTISGGAVVAGSSAPKPATPTPHIYMNVDSPKRNQYYMDRNTNAVAPESDSGPANTSATVSISGSKLTAKMKFPKD
Protein: Ca(2+)/H(+) antiporter ChaA (O34840)
Organism: Bacillus subtilis (strain 168)
Function: Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons. Does not transport sodium or potassium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23798403}; Multi-pass membrane protein {ECO:0000269|PubMed:23798403}.
Interaction partners:
- Uncharacterized protein YfkD
- Calcium-transporting ATPase
- Na
- Probable metabolite transport protein CsbC
- Low molecular weight protein-tyrosine-phosphatase YfkJ
- Putative ribonuclease-like protein YfkH
Sequence:
MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYMGRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL
Protein: RIC3 acetylcholine receptor chaperone, isoform H (E1JGP3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
Sequence:
MPATATSKPRAPLVEEGMTPKKTALIIVTVIGCIAILWPKVFHPMMFGGVPPSQPNFKDPRAAPGGCCDVVLDREQFLNATKKDTVEPFGPHLYRKQINVYTGEISLRQERPAHLHPESIYQAMRERGRAIPATPTVPILERKTSPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSSMGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAPPNPAFRQEVFGSQNHSQVEDLGGSKLVVTAIQGLIDAADEQLNGQDKQRATSDTETDSNKKNDNEKTREQPLDKQNLSNGHASSTDQNPEQETVAKGARKRRDLSAEQELTVLGMELTASCEGGHKWTGRPPTPVFRAPSEHSKLEDNLPEPQSIYLEGALAHESQILVADSQIKREEVYDSELNGSAEEPAIILSSRMTLSLINLDANQQNGNAGKSAVESPLADDIEIIGHDEQ
Protein: Killer cell lectin-like receptor subfamily A member 21 (Q4Z8P5)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVCSVPWQLIVIALGILCSLRLVIVAVFVTKIFQYSQHKQEINETLNHHHNCSNMQRDFNLKEEMLTNKSIDCRPSYELLEYIKREQDRWDSETKTVLHSTQNTGRGVKYWFCYSTKCYYFIMNKTTWSGCKANCQHYSVPIVNIEDEDELKFLQRHVITEGYWIGLSYDKKKKEWAWIDNGQSKLDMKIRKMNFKSRGCVFLSKARIEDTDCNIPYYCICGKKLDKFPH
Protein: Mitochondrial RNA binding complex 1 subunit (Q585I0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRSLTLWISKLWRPHAEHIQSLIARSVSEPRELQQARTYLHELKFEQSIEEVDDATDLLYFMHRVSYPAESHLEMKVGEFLSKCAPQVCGQHILAIGKRIQEEPGSGPLWSRVVFERGWFTSSVVAMLSTMTLEEHLTLCASYWHSLLPTPQSRCGRQLVSGSFVAVSTRLAALTAQRIEGCGDNRPCAVCLCAKLGIFLRGDTFAELRAVTLSITREMLSAAQVLEVANVLATRRSAETANSEWLVALQEALCRRRTGEVEAAHAVGLLHSMAVLNETTLSEMFEDLLLQLLPGMSQDEILKCCESLSTLSGTAPRIRTELHRTLCTMAVAGAKGKNFVDKAVPWRLRCLSMVAPQEAGKLLGRFEENIQDAEASLSPSDTRDLIRAMRSLRVFPPRAVTLCKASYLANPLQSFNQQDAVYMMYAGARTGESATSAFFKEVVNRFTTVRKFDRRKSGPHQTSVLTAELLEMVLQALQIAKGRSLLDDARVYAVLRRTLEQLQREGSLSTEANIRLLRLLAGLNVGNASLPTVLLTNVSRALTSLTSADVRELCEVLVALKSRDVLMFRALLEHLGRCGPDRTSLTAIAVAARKLKFVTYFQQSGLLQNLTSLEGWSVSDIVLIAATCSENRRAGFLALPGADVLAQAQAEDLTTLDLFLIISIVADARKQLLSMASALSKRQPLGANDLEAEDALRAIVNVVDDKDALAAVCRSATSALQAMDENMLMRTLEAVRRAPELPNVFFRVVGRCVLRLANSMTADNAIQWLELYVKHSIRDDSVGKALLSKARTRSSNCADLTDKSIRKAAAMYGKSYALHCKLKKNKEKPEWRSFEVG
Protein: Uncharacterized protein (Q38C95)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDGPFATMDEETRKTYMERGRAMMEARRAEILSHSPEKFEQLRRQGYIIFKRYLQGEQWMPLQGKLHSPLITTSEEPSKAHKQNMGSSGSSHLPQDDNITAKEYNMPTTKLAEWCAPTDKPLFPESTPAEPEELHHVALLTMCGPSVSCVDGDDEDFKQLSYNKDVATLHKTMEIQHQQIEQLNAQLRNQESEIDVLTNELKGVTEANARQLQKEEELQSLQEALQERDRELQLRLESVNEQNDSLKTQIMELHILLELKAKELQKLKDDNNALRGEVVTIQNEGDTIKESETKCKERILQLEAANSELGVQVDVSKKEVEAAHQRIKNLEQELTRERKINEDSTVAYNKVKKELECKEKTEQQKQEEIKQRKRAEKAMIRELSELQDRIHTLESTQETENNSSTAGIPLNPFAKMVIQGEASQPRVEDDDDAVVFGVGDSVTPSVCVETGMALRVKELEMCISGLQQQLESERADAAREVDSLRHRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNALQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNALQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELETCRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNALQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNALQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELETCRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNALQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELEACRTGNESDDAILERLNTLQACNDQLKEELRELEERQQVELANVTQEAADRIAEHDELLRQKLEEYKAEQEAKFLEELETCRTGNESDDAILERLNALQACNDQLKEELRELEERQQVELANVTQEAGGTRGYCGVTVFVASTSSSVGSVRSLLGADSCLPCINLETADCGAKEAECCISHREVVGNGSHCVDVLKGSEKVSSRVQTDSPEAIGVVCRSFVDMTEDRENGERVDYGNLNGLSYCNFSGDIPDDIGMGNLVICRKQSKCNKSCQVDDGVVPLDDSNEAELRVEDCQTLPDVTRNRVELQREEQSRLHSENGGSEKEVHTAELDHTTLKHNVVEDLFAEKVLTIPLVVEYLFRAVLDAHEYLVRHHVNFQRKLLSRCDVIERAASDAMIEGERQCEEFMAVVEGAEVERQGLLRQITELQQEVATFKASSERVESELCSNKEEHSKVIRKLHEKLDATQHEMEVVKVEYANSLHKMELVKTENANVLHLFSELKKTAADVEDEQRREVVRLQEALREKTHTSRELLELTEQKLAAALEEVDQCKCSREDLEKQLRSTKSSLDRVIPRLERAETERDSLESQLLDATQEVQLLTQRNRTAEEASRRQADALTATVEELREANTKLGESCKEQQAQLDSLKAQLAVAETELERLRMRATQQESDAQRLNGKLCELESSSTLQVEEAAAALRAAEMRIAALEPRKAALQEEVDHVRRKNCELQGCCDELKERLRQAADTTQNAEQMHNRRVQQLNEQVEALQLEVKQLQEAHDGLVADREQLVREQVGAAQETERIKQNLERCNQQKERLQNEIQWQRESYESEIQAAQETLNGAREELSKWRHTLEEAEAQQNAMRDTISMLQVERTSNHEQIRAVRLQLREYQELLAQERGYLHETGLKFLRSCSDECSVQKSPSVPYTPQRECGTRETCSLTSAPAGCCDSQKTQGSASQKSIARLRNIVAQKSLLLEEREAQVESLYSEMKTAIVHVVQEARNAQLGSKALAPVDQRELLLNNIMHNLLLRLGRLSRVVREPSTDSTGSGSRDPANAEVSPNSSTNPEAVLNFSSAATPKERVSGGGDESTDAR
Protein: Adenosylhomocysteinase (EC 3.13.2.1) (Q7T2B5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNVGELSAAFTAVPTHKSVKKIQFANQEDKQEFSKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPREKSQVNSKGSSDFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKVAGCTHITAQTAVLIETLVALGAQCRWTACNIYSTQNEVAAALAESGVSVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPSVFKKVRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCSALKALGAIVCVTEIDPICALQACMDGFRVVKLNEVVRQMDMVITCTGNKNVVTREHLDRMKNGCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRVILLAEGRLLNLSCSTVPSFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPNFDAHLTELSDEQAKYMGLNKNGPFKPNYYRY
Protein: adenylate cyclase (EC 4.6.1.1) (Q9Y1V0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDVELEEEEERICLRTAEEGQLANMDDDKLVSDEVHLRQLSATPSSAFSLQHSRGSDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSIASIAGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNTSMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQASSSYMPSFRRIDQIETTISKSHNDAL
Protein: Dolichol phosphate-mannose biosynthesis regulatory protein (Dolichol-phosphate mannose synthase subunit 2) (DPM synthase subunit 2) (Q9Z325)
Organism: Rattus norvegicus (Rat)
Function: Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9724629}; Multi-pass membrane protein {ECO:0000269|PubMed:9724629}.
Interaction partners:
- Dolichol-phosphate mannosyltransferase subunit 3
- Dolichol-phosphate mannosyltransferase subunit 1
- Phosphatidylinositol glycan anchor biosynthesis, class Q
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
- Phosphatidylinositol glycan anchor biosynthesis, class H
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
- Phosphatidylinositol glycan anchor biosynthesis, class Y.
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- dolichol kinase
- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Sequence:
MATGTDQAVGFGLVAVSLIIFTYYTTWVILLPFIDSQHVIHKYFLPRAYAVLLPLAAGLLLLLFVGLFITYVLLKSQKVTKKAQ