wanglab/gogpt-training-data huggingface dataset:
Protein: Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] (P03162)
Organism: Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)
Function: Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery (By similarity).
Interaction partners:
Sequence:
MQKLTRNHWIGLGDCFGGITTVYCGEKLKLLTIFLVCVLGCQLLRNIEVEMPRPLKQSLDQSRWLREAEKQLRVLENLVDSNLEEEKLKPQLSMGEDVQSPGKGEPLHPNVRAPLSHVVRAATIDLPRLGNKLPARHHLGKLSGLYQMKGCTFNPEWKVPDISDTHFNLDVVNECPSRNWKYLTPAKFWPKSISYFPVQVGVKPKYPDNVMQHESIVGKYLTRLYEAGILYKRISKHLVTFKGQPYNWEQQHLVNQHHIYDGATSSKINGRQTDRRRRNTVKPTCRKDDPKRDFDMVRQVSNTRSRVRPCANNGGDKHPPESGSLACWGGKESRIIKSDSSRDSSAPVDSRGRPKSTRSFSPLSRRKTTGNHHHSSVFPSSVEATTRGRSTPGKSVSPRDSSAIPVRTSGASDKNSPLEEENVWYLRGNTSWPNRITGKLFLVDKNSRNTEEARLVVDFSQFSKGKNAMRFPRYWSPNLSTLRRILPVGMPRISLDLSQAFYHLPLNPASSSRLAVSDGQRVYYFRKAPMGVGLSPFLLHLFTTALGSEISRRFNVWTFTYMDDFLLCHPNARHLNAISHAVCSFLQELGIRINFDKTTPSPVNEIRFLGYQIDENFMKIEESRWKELRTVIKKIKVGEWYDWKCIQRFVGHLNFVLPFTKGNIEMLKPMYAAITNQVNFSFSSSYRTLLYKLTMGVCKLRIKPKSSVPLPRVATDATPTHGAISHITGGSAVFAFSKVRDIHVQELLMSCLAKIMIKPRCLLSDSTFVCHKRYQTLPWHFAMLAKQLLKPIQLYFVPSKYNPADGPSRHKPPDWTAFPYTPLSKAIYIPHRLCGT
Protein: EF-hand domain-containing protein D2 (Swiprosin-1) (Q96C19)
Organism: Homo sapiens (Human)
Function: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Subcellular location: Membrane raft {ECO:0000250}. Note=In a mouse immature B-cell line WEHI-231. {ECO:0000250}.
Interaction partners:
Sequence:
MATDELATKLSRRLQMEGEGGGETPEQPGLNGAAAAAAGAPDEAAEALGSADCELSAKLLRRADLNQGIGEPQSPSRRVFNPYTEFKEFSRKQIKDMEKMFKQYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKNMIKEVDEDFDSKLSFREFLLIFRKAAAGELQEDSGLCVLARLSEIDVSSEGVKGAKSFFEAKVQAINVSSRFEEEIKAEQEERKKQAEEMKQRKAAFKELQSTFK
Protein: Grainyhead-like protein 1 homolog isoform X1 (Grainyhead-like transcription factor 1) (E7FCE3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU01313}.
Interaction partners:
Sequence:
MSQEHENKRAVLVLPNDPAYNQRRPYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRTISQQKTDVLGSDVDPNKRNMLTPLQETSMQLGDNRIQVLKGVPLNIVLPGNQHVQDKRGLFPSPDTTVTVSIAPVASNSVKTEGPSHGFSVTVPNPHCAEPDSHTVVFDRQLPHNQFSPNTQPRTPDSTFPENPDVFSFPGDLQLRMGPITQDDYGTFDTVSGNNFEYILEASKSLRQKSGDGTMTYLNKGQFYPITLRETDNGKLLQGPICKVRSVVMVVFGEEKSRDDQLKHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEISYNAISFTWDISEEAKIFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQSRRKGKCPDVNPPLGNFGADVKVPLLHKRTDMTVFRTLTDFETQPVLFIPDIHFSTFQRHAFTAEDSEEGSAMKRLPYTEEEFGSPPNKLARMDEPKRVLLYVRRETEEVFDALMLKTPTLKGLVEAISEKYEVSLEKIGKVYKKCKKGILVNMDDNIIKHYSNEDTFQIQMEEMGGMIKLTLTEIE
Protein: DDAH family member 2, ADMA-independent (N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (Q5SRR8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLH
Protein: Putative diacyglycerol O-acyltransferase Rv2484c (EC 2.3.1.20) (Putative triacylglycerol synthase Rv2484c) (P9WKB3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Upon expression in E.coli functions very weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity.
Interaction partners:
- Phospholipid/glycerol acyltransferase domain-containing protein
- Glycerol-3-phosphate acyltransferase
- Possible triacylglycerol synthase
- Triacylglycerol lipase
- Diacylglycerol kinase
- Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1
- Probable enoyl-CoA hydratase EchA14
- Polyketide synthase Pks13
- Uncharacterized oxidoreductase Rv1543
- Phenyloxazoline synthase MbtB
Sequence:
MAESGESPRLSDELGPVDYLMHRGEANPRTRSGIMALELLDGTPDWDRFRTRFENASRRVLRLRQKVVVPTLPTAAPRWVVDPDFNLDFHVRRVRVSGPATLREVLDLAEVILQSPLDISRPLWTATLVEGMADGRAAMLLHVSHAVTDGVGGVEMFAQIYDLERDPPPRSTPPQPIPEDLSPNDLMRRGINHLPIAVVGGVLDALSGAVSMAGRAVLEPVSTVSGILGYARSGIRVLNRAAEPSPLLRRRSLTTRTEAIDIRLADLHKAAKAGGGSINDAYLAGLCGALRRYHEALGVPISTLPMAVPVNLRAEGDAAGGNQFTGVNLAAPVGTIDPVARMKKIRAQMTQRRDEPAMNIIGSIAPVLSVLPTAVLEGITGSVIGSDVQASNVPVYPGDTYLAGAKILRQYGIGPLPGVAMMVVLISRGGWCTVTVRYDRASVRNDELFAQCLQAGFDEILALAGGPAPRVLPASFDTQGAGSVPRSVSGS
Protein: CASC3/Barentsz eIF4AIII binding protein (Q8H1F3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RNA-binding protein Y14
- Protein mago nashi homolog
- THO complex subunit 4B
- Protein REDUCED CHLOROPLAST COVERAGE 3
- SEED MATURATION PROTEIN 1
- Eukaryotic initiation factor 4A-III homolog
- Pentatricopeptide repeat-containing protein At1g30610, chloroplastic
- Partner of Y14 and mago
- Regulator of nonsense transcripts UPF3
- Nonsense-mediated mRNA decay factor SMG7
Sequence:
MATSEAEYESDPEELNRSLATRRREASDDDSDDDDAVRDVKNQRAVVDSDLSDEEVGTVKYDNDEDGEDSYEDDEEESGGGIDNDKSGVVKEAGDMNGEEENEKEKLQAAVPTGGAFYMHDDRFQEMSAGGNRRMRGGRRQWGSGEERKWGHDKFEEMNTGEKHSDQRMSRGRFRGHGRGRGQGRGYARGSSSNTLTSSGQQIYVPKAVSRGRGPRKSDTPLRNENQAHSEQSKQLRNSNGSQNSREKMPHLDSRRSPTAPAKTENQGAHAKKNVAVSSLSSASPPFYPSAPSSNVVHGIQVSMERLHTNESVTPSGKKYRNTKSGYSPVWTAKTLQSTSQGRGAPAAGNTFYPQSHSQGDRFSSPMQLNGDSKGTGQRPSGQGFDQHSAVVRSLSSSPQKTSLSRNRYPPDEIESSSETAALIAKGKGTLRPGGSSSFMYSGSQMMGRPESLTSADNSNFPTFLPVMQFGGQHGGVPTFGMAYPGYVQSEDGVRNPEMTWMPVLAGPGALGASYSPPPYAAHQAHNPGLPSSAGFSSKDSSTNTLNDLVKPMESPEVAENGVSERQSNNPSKQPRRYSEMTFSK
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (Q9FE18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Rhodanese-like/PpiC domain-containing protein 12, chloroplastic
- Peptidyl-prolyl cis-trans isomerase FKBP12
- 10 kDa chaperonin, mitochondrial
- 10 kDa chaperonin 2, chloroplastic
- Annexin D4
- Glycine-rich RNA-binding protein 3, mitochondrial
- Synaptotagmin-1
- Peptidyl-prolyl cis-trans isomerase Pin1
- Kunitz trypsin inhibitor 1
Sequence:
MGKDAKAGGKGKGKQASGSEEAPSKGKGKAGKAADGLGTCTYVKARHVLCEKQGKINEAYKKLQDGWLSNGDKVPPAEFAKIAAEYSECPSGKKGGDLGWFPRGKMAGPFQDVAFNTPVGVTSAPFKSTHGYHIILSEGRKN
Protein: Angiopoietin-like protein 3 (B1B565)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKIILLLLFVAPLALSVRAEKDFAFLDSAATPETKSRFAMLDDVRILANGLLQLGHGLKDFVHKTKGQMNDIFQKLYIFDRSFYELSLQTSEIKEEEEQLRQTTARLQINNEEIKNLSQEMNLKIEDLIQNKIQLQEKVWGLEDKVTKLAIIQPTVQETNEISSLKAFVEQQDNHIKQLHKVVEDQHVQLDKQHNQIMELEDKLNHIELQELAENSFLEEQAESNEGSPFLVHNSTAVMHKLEGATPDCTALYNSGIRSSGIYTIKPNGSEAFDVYCEMKFGTSWTVIQNRVDGSLDFNQTWDAYTNGFGDLNEEFWLGLNKTFSITKQGDYILRIELQDWKDNKRYVEYAFTLGGPETDYVLQLSRISGSIPNALPEQTELRFSTADRDMAIINDLDCPQNYLGGWWHSECEETNLNGKYVTPRSKGRLDRTKGLYWKPKNGRYYLLKSTKIMIHPTDLKIFD
Protein: Perilipin (Q5U2U5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
Interaction partners:
Sequence:
MASVAVDPQPSVVTRVANLPLVSSTYDLVSSAYVSTKDQHPYLRSVCEMAEKGVRTVTSVAVTGALPIIQKLEPQIAVANTYACKGLDRMEARLPILNQPTSEIVANARGAVTGAKDVVTTTMAGAKDSVASTVSGVVDKTKGAVTGSVERTKSVVNGGIDTVLGMVQLMSSGVENAISKSELLVDQYLPLTQKELEMEAKKVEGFDMVQKQRYYERLESLSTKICTRAYHQALGRIKDAKQKGQETISQLHSTVHLIEFARKNVHSANQKIQDKLSVSWVEWKRIVGYDDTDESHCAEHIESHTLSMARNLTQQLHTTCQTLLFNVQGLPQNIQDQAKHLGVMAGDIYSAFRNVTSFKEVSDGVLTSSKGQLQKMKESLDEVMDYLVNNTPLNWLVGPFYPQSTEVDKASLKVQQSELTTQ
Protein: Nuclear envelope integral membrane protein 1a (B9X187)
Organism: Xenopus laevis (African clawed frog)
Function: In concert with ran, required for proper eye development. May be involved in the expression of early eye marker genes. Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility (By similarity).
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:19167377, ECO:0000269|PubMed:25946333}; Multi-pass membrane protein; Nucleoplasmic side {ECO:0000269|PubMed:19167377}. Nucleus envelope {ECO:0000269|PubMed:19167377}. Note=Localization in the nuclear membrane is essential for its function. Colocalizes with lamins and banf1-a/b at the nuclear envelope. {ECO:0000269|PubMed:19167377, ECO:0000269|PubMed:25946333}.
Interaction partners:
Sequence:
MAGDVEGGGCRVSWGALLTLLLLPLPSLCTLASGKEPHVIKLYEGKVVRYNESKNFCYQRTYEPKWSDVWTKIQIRVNSTKMIRVTQVENEEKLKEMETFNMFDLFSSFLKEKLNDTFIYVDLYSNKTCIKVHVIDTDTYYSVALSRGFDPRLCFLFLCGLLLFFYGDALSRSQLFFYSTGITIGMLASMLILVFMLSKLMPKKSPFVALLLGGWSVSIYIIQLVFKNLQAICSEYWQYLLGYLGIVGFVSFAFCYKYGPLENDRSINILTWTLQLIGLLLMYISVQIQHIAVTMVVIAFCTKQIEYPVQWIYILYRKIKRKRAKPSPPRLLTEEEYRKQGEIETRKALEELRGYCSSPDFATWKMISRIQSPKRFADFVEGSSHLTPNEVSVHEHEYGLGGSFLEDELFGEDSDIEVEMDIEQPLYLVPRSCF
Protein: Protein VAC14 homolog (P87145)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Polyphosphoinositide phosphatase
- 1-phosphatidylinositol 3-phosphate 5-kinase fab1
- DNA repair protein rhp54
- Autophagy-related protein 18
- Presequence translocated-associated motor subunit pam17
- Phosphatidylinositol 3-kinase pik3
- Vacuolar protein sorting-associated protein 38
- Serine/threonine-protein kinase vps15
- Vacuolar protein sorting-associated protein atg6
- PtdIns3K complex I subunit atg38
Sequence:
MDNLLVRGLTHKLYDKRKATAYELERVVKGYLENDETEKIRAVISQLANDFVYSPARGPNATFGGLIGLAAVAIALGPKIDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFRYFNLIFDVLCKLFADTEITVKNGAELLDRLIKDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFISYLPFLLDGLMNYLSDPNESIRIVTSNCLYDFLREIQKIAKVKYHILQRDEESEPDFFDSMVRRNMSDAELKEISDYVESSLRDGSFILEAHIQIDYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKDVLLQIPKVLENLLPLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGGKLINMHDPIFQTLLLQLSDPSDLVVSRTLELLAHIAISHKSVNLVPFLKSLLQMFAEDRKFLNSRGNLIIRQLCNYIEGERVYTSFAGILETEENLELASIMVEVLNNNLFTAPELYDLRKKLKQSAPKLQNIFTTLYTAWCHNSIAVFSLCLLSQNYEHAANLLSVFAEIEFNIDMLIQLDKLVQLIESPVFTYMRLQLLEPEKYPYLHKALYGILMLLPQSSAFRTLRDRLQCSSTPRTNTILANERLPRSRRDDPYWTDLLERLKAVQLSHQNNYREPIRATRLALAGALPSTPTATTISTTTSASGITTTASNSRDSFITRLPPTAALSTGARKKPKQ
Protein: Integrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Q61711)
Organism: Mus musculus (Mouse)
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P21815}.
Interaction partners:
- Osteopontin
- Integrin alpha-V
- Osteocalcin
- Integrin beta-3
- Osteocalcin-2
- Dentin matrix acidic phosphoprotein 1
- Integrin beta-5
- Osteocalcin-related protein
- Runt-related transcription factor 2
- SPARC
Sequence:
MKTALILLSILGMACAFSMKNFHRRIKAEDSEENGVFKYRPRYFLYKHAYFYPPLKRFPVQGGSDSSEENGDGDSSEEEGEEEETSNEEENNEDSEGNEDQEAEAENSTLSTLSGVTASYGAETTPQAQTFELAALQLPKKAGDAESRAPKVKESDEEEEEEEEEEENENEEAEVDENELAVNGTSTNSTEVDGGNGSSGGDNGEEAEAEEASVTEAGAEGTTGGRELTSVGTQTAVLLNGFQQTTPPPEAYGTTSPPIRKSSTVEYGGEYEQTGNEYNNEYEVYDNENGEPRGDTYRAYEDEYSYYKGHGYEGYEGQNYYYHQ
Protein: Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) (O35740)
Organism: Mus musculus (Mouse)
Function: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.
Subcellular location: Nucleus. Note=Colocalizes with EP300 in dot-like structures. {ECO:0000250}.
Interaction partners:
- Histone lysine acetyltransferase CREBBP
- Histone acetyltransferase p300
- Forkhead box protein O3
- Hypoxia-inducible factor 1-alpha
- Transcription factor AP-2-alpha
- LIM/homeobox protein Lhx2
- Endothelial PAS domain-containing protein 1
- Aryl hydrocarbon receptor nuclear translocator
Sequence:
MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPTAGHQMNGTNQHFRDCNPKHSGGSSTPGGAGGSGTPGGSGGTSGGAGGSSAGGSGGGSTMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC
Protein: Glutathione S-transferase F5 (AtGSTF5) (EC 2.5.1.18) (GST class-phi member 5) (Q9SRY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Glutathione S-transferase U10
- Glutathione S-transferase U18
- Glutathione S-transferase U16
- Glutathione S-transferase U28
- Glutathione S-transferase U12
- Uncharacterized protein At5g39865
- Fimbrin-4
- Glutathione S-transferase U5
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8
Sequence:
MGINASHVPETCYHHCNQTFESSRQCFKWCQELARKDEYKIYGYPYSTNTRRVLAVLHEKGLSYDPITVNLIAGDQKKPSFLAINPFGQVPVFLDGGLKLTESRAISEYIATVHKSRGTQLLNYKSYKTMGTQRMWMAIESFEFDPLTSTLTWEQSIKPMYGLKTDYKVVNETEAKLEKVLDIYEERLKNSSFLASNSFTMADLYHLPNIQYLMDTHTKRMFVNRPSVRRWVAEITARPAWKRACDVKAWYHKKKN
Protein: F-box only protein 10 (Q9UK96)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:31570756}.
Interaction partners:
- Cullin-1
- S-phase kinase-associated protein 1
- Apoptosis regulator Bcl-2
Sequence:
MEAGGLPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNWPNQPDVEPESWREAFKQHYLASKTWTKNALDLESSICFSLFRRRRERRTLSVGPGREFDSLGSALAMASLYDRIVLFPGVYEEQGEIILKVPVEIVGQGKLGEVALLASIDQHCSTTRLCNLVFTPAWFSPIMYKTTSGHVQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHIFLHNVPLCVLENCEFVGSENNSVTVEGHPSADKNWAYKYLLGLIKSSPTFLPTEDSDFLMSLDLESRDQAWSPKTCDIVIEGSQSPTSPASSSPKPGSKAGSQEAEVGSDGERVAQTPDSSDGGLSPSGEDEDEDQLMYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLQQELQKDKEAMALANSVQGCLIRKCLFRDGKGGVFVCSHGRAKMEGNIFRNLTYAVRCIHNSKIIMLRNDIYRCRASGIFLRLEGGGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGIIRNNQIFSNKEAGIYILYHGNPVVSGNHIFKGRAAGIAVNENGKGLITENVIRENQWGGVDIRRGGIPVLRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGVAVFSQKDGSSELPRGHRAQENFSEDGDAILWETELEKEDDPLRRPITIALVESNSINHNGASGLYVQSSEALHVITNVIHANGDRGITVAQSSQPTRVANNSISCNRQSGVKVEAQCKVELRGNGIYDNRGHGIITKGDSTIVIENDIIGNRGSGLQLLPRSDTKVIKNRIHSFRAYGIAVRGRAKALVQENIIFQGKTSKTIFQQISNNRECIMQNNKFLVFKKKSDTWRLVNPPARPHLENSLRRPSAAHNGQKVTAMATRITARVEGGYHSNRSVFCTIL
Protein: Membrane glycoprotein RL11 (Q6SWD1)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Subcellular location: Host membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MQTYSTPLTLIIVTSLFLFTTQGSSSNAVEPTKKPLKLANYRATCEDRTRTLVTRLNTSHHSVVWQRYDIYSRYMRRMPPLCIITDAYKETTHQGGATFTCTRQNLTLYNLTVKDTGVYLLQDQYTGDVEAFYLIIHPRSFCRALETRRCFYPGPGRVVVTDSQEADRAIISDLKRQWSGLSLHCAWVSGLMIFVGALVICFLRSQRIGEQDAEQLRTDLDTEPLLLTVDGDLE
Protein: Nuclear factor 1 (F7END1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQAETSN
Protein: Uncharacterized protein YDR132C (Q03900)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative acetyltransferase YJL218W
Sequence:
MSNSPTVATLSQEYFDPNIPQILPHEKMYKIQVGKSLFKISGASLSSDGPSFFTEYFSKKRSPSNNDDSNNDTMESNKNEVLFIDRSAEVFEWIYQHLQGYIIEIKDEVQYTMLFADAMYYNLPRLRSLLKETDYYFTNIGGQSFKIAKNLFRREGDSPNYFEIYAATVYIDVEELIISKKLLRPPSHSAPYIPRSSEYFKDLLTLLGGASIDLDDNKRNALIKECRYYRLLNLEQRLIKSHISYNPITRKEEICLLLKDLSKKGITFPASSAFSTSPYFEDDFCSINECDSLSKTREQPANKKIKLDMTEKYNDSWNMLCYKRPFLDKHPRELIFQINSTDCTIILNKESQSIHVDITGESAYKFEALFGSHLPNTPSGAPKLKNYQYRFPSDSTQTKIETHYLLPACIYLCDLDINGIKISQVQTLLTDKNKFNDRVIDVSDPLDLRFCSGLKLYLRKSLWKLAVKDGNIMLIAIKAIAFNGTKEYYKGYEYL
Protein: Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] (P11678)
Organism: Homo sapiens (Human)
Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
Interaction partners:
- Eosinophil cationic protein
- Non-secretory ribonuclease
- Bone marrow proteoglycan
- Proteoglycan 3
- Interleukin-5
- Large ribosomal subunit protein mL64
Sequence:
MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT
Protein: Fumonisin cluster-specific transcription factor FUM21 (W7LKW1)
Organism: Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
Function: Transcription factor that regulates the expression the gene cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2 (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
- peptidylprolyl isomerase
- peptidylprolyl isomerase
- FK506-binding protein
Sequence:
MAGSIVFVTDNQISANSRHKPRFRRRRGACESCKRRKVRCNGTNPCNQCQKSSIECLYSSSSWKANDGDTERGPSGSPVQHTRGSLTPPQTSPYGGMACNGSAEESSRFDGSDAHSLLMSLSNTDCTTNTEATEMSQWQNWFVSDLPLGSDVQLTGTSDESLTDWLDPQLVNPADTAAIMQTLSGEDLFKSSGPSYGMSEPPSRDSDPGFNTARNEQIAGFIQKLRSQRPFVLRDENPEAPPGNIRGFYDAKFISQCFDACDADPEGVRVLLERKSMDLIADEITKYALAVDTETSVLFHSLMAIGCHSLNLDQGHRAIGKGKYPASKFFKEALNARQHLRDSPSLGGLQAILTMAYFSARVGDDSTSSFLADAAFCVQTLQLHNAGAIEQKYNSFLEQQVAKRALWFLYSLEKPRCLAQGLLPLIHDDFVDYDPPPSANYSTSEVDWFAINARFARICSSIIKERLGCKLGRTPSRRGKDRASEYSASSVIKRLESLLEEWRDDLPFAGDFDATRSDEFAASTCAERRHRIKCLNKYWSAIIATHSGQARGVAEDGGAGVRLSRARCIDAAQAILQNSHYVTSTDILSDISLYYYITVATRVIMTVVIRDRFASDITGDPVQKNTATRKRETTHGRSIMSYVGIAIGLFSRLSLDIDVPVDEVTELGKLGR
Protein: UBC protein (Ubiquitin C) (Q96C32)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV
Protein: Multiplexin, isoform S (X2JGC3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAMVISTRAKLVITALILFFLLGIVLVTGSTKGWFNPNRYNGERVAARIQATDIFDASGMQPPGQTQYTHERPYRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAKGVPGEKGDAGQKGERGDPGHKGAHGPSGAKGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGRPGMTGPKGEMGPKGPKGDSGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPKGEPGVDSRSSFFGDASYYGRPGARSSLDELKALRELQDLRDRPDGTAEPPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVEALSQDRKRKKREIGDGSSHGESESREFKTADEYAAHLENLLL
Protein: Zeta toxin domain-containing protein (Q382R5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKTEVETKTKTTDVTEAASQHARGSTTGNGFISPLEASQCYRAVCGPCHFENSGCQSHSTLAAAIAHPATTQILQELILFAFTPGRHSGGPQQMGMVNSVMARKPFGVPPEHALTWLDIKRSLLFCGVKQHRCPKALRLLWGSLLALCCNCSQHTIDEKKVPEGTTLDDGSSIQCSSHFPAAEIAILVRHEDFRWVAQLLAAGESLGSCTVARGKAVPLEDFVSTIVDLQHHITSTVAESYQVPRSQTKYVLIVDADSFHCCIKRFLAQELRGEHITLSPLPRWNGAQAIVQQRRALVVFCGGTSGCGKSTLSSLISTHLSISTTISTDTIRQALRRTLPGGEFPELFTSTYAAHSNPVASLEGGGNACNGNLDGDGPEHVIAAYEKQCATVLPVLDRTLEKFVSRYQTVVVEGVHLLPDYMHRKMVELQTRGVLCVSFLVYIKKRERHLERFCTRAKSMSLSPTRNKYVSNFENIRVIQQHLLEQAARLDVNLINNTNVDKSLMMVHTRLLDRVHHFNVAPGFQQHVGVGEETSTARAQVGTNSGIDRRDDETEVTSAAHLYNMPYSNVSGKHMLALLLHRRNEKKHRMHNSLFSRCHCCERNSLVTQVRRSRSAESLTTLKLSSLQVCTDEWDGRDNSLLVPHKQSEEPTTNSSECGCITNAMVAGTSLIGIDCQNRNTDADDANVDDYHDPTSMQALEAGHTTRSMRSSSAFTHFAPISPSVRSASADTERLGGRMCKRSRGWAAIQLSISNRAEQGRNENDEEMKSLWGDNFSSETPSLTCC