wanglab/gogpt-training-data huggingface dataset:
Protein: Meiotically up-regulated gene 176 protein (O74389)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MPSLNQEETPKKTKNPYRKGHSRRQSRHSIPSDELNSNSSKSLNNDRISRTIENSLQKETNSDNKIKKLSKTKSNPTNPKSEEDPSQICQSFDESNIITPSKYLFPLSKDYSPNEGLFQTDMNEKNPHDLWNPTVPMAYLSRSLQGLTISKINETEQKFPLSSVHAYVEIGEGMFSMEIVTEQLRLLGATVHASLQMTEENPVSHAVLYDCSQETLKKISSAQVPIVCVSPKWVLACYSSKYLVDEEMYLVDPQDILQTKCLQTDDSELLNPLDPFTDTQMIQDPSDAFFFDTQAENLEPFVNGSPDSHCFNADSFLDQTLSDDYEFGLITCSDSNESSMSNDAQRENNPETISQISLSPTADLFSSFKITTDLEMTHLESAKKKYLAYKPLIGSPLKKKVSLIDF
Protein: Probable calcium-binding protein CML35 (Calmodulin-like protein 1) (Calmodulin-like protein 35) (P30188)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML14
- Probable calcium-binding protein CML34
- Probable calcium-binding protein CML13
- Probable calcium-binding protein CML21
- Proton pump-interactor 2
- Probable calcium-binding protein CML28
- Pentatricopeptide repeat-containing protein At3g18110, chloroplastic
- Phloem protein 2-A10
- Peptide methionine sulfoxide reductase B4
Sequence:
MKLAASLNRLSPKRLFRTKSKASVSRSEPSSFSSNASSSSSDGSYGNLKQGPTATPISVLPQNSGDFYTELVQAFKLIDRDDDGVVSRGDLAALISRLSHEPPSQEEVSLMLREVDGGDGGCISLEDLASRVAGTSGEGSVETEELREVFEIFDVDRNGKISAEELHRVFGVIGDERCTLEECMRMIATVDGNGDGFVCFDDFCRMMVPAMNDHHH
Protein: Kank, isoform B (A1Z9W7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASLQIRIVLRRESRKSNSCIGGNQSPTGTPRPFLRSNTLPLRQRPSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQENGSVSSSSLQSPVISETGQTTADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSPPSPGLKTASPVQFTPQRISPVSLESLGARMRSSSTSASPSPSVVRRDVSTQAVVRPPATRDVSVGHQPTTRNVGVQPSETVYSKEELDKKVEQALTNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTTPERPKLKYHVGVTVKPATRENFTSCKPDVRHVGSSDDRLDDVLCEKCAVSKRSVACGPETPAEKVKPAPQMPGRSNTFSLGENETVSVVRKTIGCQTPVTLVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQRLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSACNTEEVRKRDVGCGDIVKPHISIACAANYCDSCKEAIQDLARGFSKASPTATRTGGAVRRSTSADSRIPRPKHLSSPSPVRKEFMRQNTYTLATPSPTPSPQVERKARLSSLQEKPPSVSSFQASEPLPESQSFIRQPQKDSLDLSLLGEDELIVREEKRVSISWSRDASPAPLMTSSGTTKSESPEQEPAMSSSSDSSPPIDVQIAQGARKKSSTPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSEPRKKTELSQSLKDALKIINDSLLKKLGAKPISSQSLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGDATRSSLISPPRHKRQPSQ
Protein: U1 small nuclear ribonucleoprotein 70 kDa (B2RZ74)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D1
- U1 small nuclear ribonucleoprotein A
- Small nuclear ribonucleoprotein G
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein E
Sequence:
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKDERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGGGGGGGGGGGGGGGGDMAEPSEAGDGAPDDGPPGELGPEGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDREHKRGERGSERGRDEARGGGGSGQDNGLEGLGSDGRDMYMEAEGGDGYMAPENGYLMEAAPE
Protein: Talin 1 (A0A8I6ABG6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MVALSLRISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPSDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKAEHGSVALPAIMRSGASGPENFQVGSMPPAQQQVTSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQAALDDFDALPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQMFVPRGAGAPSPPDSPTDILMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAAREGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTTDPAVQAIVLDTASDALDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHFGRECANGYLELLDHVLLTLQKPNPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH
Protein: Candida glabrata strain CBS138 chromosome L complete sequence (Q6FKG2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome A complete sequence
- Transcription factor MBP1
- Candida glabrata strain CBS138 chromosome K complete sequence
- Candida glabrata strain CBS138 chromosome A complete sequence
Sequence:
MVSLSGSGGKAKSADSVNKWRIPHYYKRGKSVGSTPVSEVVNSPLRAVQNEPSVSSPKKILLEERNRATPRSRKSSKKGQMVFVNYTVQDDDETGDKVDDDKADDVADVVPKTSAVTQAAILDNKHVLTSKRKSSRRRMLKIFGSSKEQVIPLEPESHQDAQKDLAARLIENSAESSSNTSNTSSSSSTPNSQGRSYGSFLKYNKFCSGSDRSKNNNASTDFNAMLINNQNKMSNHLALNYSAAKSAEGLLNHFAEDEMVPKSLPDPNLAKPAIRVGPTDRKRSVSSSAIPMKAASSTSLTSKVTKPARKMSTTTTLSNPSSHNTPFTEFENSNLTDSYQYSDPYISRNSNMSNASITSFISSMNVGNSTNITPLTESTKVDTNDNFNALMKGHISEPGEENDASVAFTKLFHRKRANTGGSTSSSNSNTTFQNSTQNITKSGVSKISAHRTTSLNSLASIANRFSPIRTASPVRPRSNTRSSSTCRHSRDLSGLVPLTTPEYLGPSTGTEVYLDTQSKRTVNHKKKQESISELSKFQNTPTSNNHHTANLATTPSSFLGTSYFANHPGQQTSYSNTSTPAATDINSLSTTYFSGKTAVGNSRQTSDISYMTEKEFHTDSEPFDTNDVPTPIEGVSSMRGISNNAIQELDEEERPNEDCSDTRKSEIDLMRLLDTNISDRKLAVNNNTKHFDDNDFNRSANSGGTRSNTAMDSFMTNFLYETQIDDTNETQQNNNDNSIFEDFDYKSLGLDNMAPNNRQILNDDCEMETKGTQGQLSSNFDFNFDTDLPIGHEFLPDSLASGQNPDQNHAAYGSRGYQIPDHQVMNNQNAQTDTTFKALSNDLYYGN
Protein: Dicarboxylate transporter 2, chloroplastic (Glutamate/malate translocator) (Q8L7Z9)
Organism: Spinacia oleracea (Spinach)
Function: Glutamate/malate translocator involved with DIT1 in primary ammonia assimilation and in the re-assimilation of ammonia generated by the photorespiratory pathway. Exports the end product of ammonia assimilation, glutamate, from plastids to the cytosol. The precursor for ammonia assimilation, 2-oxoglutarate, is imported from the cytosol by DIT1.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MESLALLPTLSLSTTTTTSKATAFLRSSTTSLHHRRPHLSLSLSSTPKPTLTFSSHSHSHSLSSKPLLALKPLNATASSSSSPATTSPPPTKSGAKLIPLILSVSVGLLLRFAVPKPAELTPQAWQLLAIFLSTVAGLVLSPLPVGAWAFLGVTASVVTKTLPFPTAFCAFTNEVIWLIVISFFFARGFVKTGLGDRIATYFVKWLGKSTLGLSYGLTISEALVAPAMPSTTARAGGIFLPIIKSLSISSGSLPGGESRKKLGTYLIMTQFQSAGNSSALFLTAAAQNLLCLKLAEELGVKIASPWVFWLKAASLPAFVALLLTPLILYKLYPPELKDTPEAPALAAEKLKNMGPVTKNEWVMVGTMLLAVSLWVFGEKIGVSSVVAAMLGLSVLLLLGVLDWNDCLNEKSAWDTLAWFAVLVGMASQLTNLGIVSWMSGCVARSLKTMNLSWPAAFGILQAAYFFVHYLFASQTGHVGALYSAFLAMNIASGVPGVLAALALAYNTNLFGALTHYSSGQAAVYYGAGYVDLPDVFKMGFIMAVINATIWTVVGGVWWKILGIY
Protein: ATPase 6, plasma membrane-type (EC 7.1.2.1) (Proton pump 6) (Q9SH76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Soluble inorganic pyrophosphatase 3
- Soluble inorganic pyrophosphatase 5
- Soluble inorganic pyrophosphatase 4
- Soluble inorganic pyrophosphatase 1
- Soluble inorganic pyrophosphatase 2
- Soluble inorganic pyrophosphatase 6, chloroplastic
- Cation/H
- Alpha carbonic anhydrase 5
Sequence:
MAADISWDEIKKENVDLEKIPVDEVFQQLKCSREGLSSEEGRNRLQIFGANKLEEKVENKFLKFLGFMWNPLSWVMEAAAIMAIVLANGGGRPPDWQDFVGITCLLIINSTISFIEENNAGNAAAALMANLAPKTKVLRDGRWGEQEAAILVPGDLISIKLGDIVPADARLLEGDPLKIDQSALTGESLPATKHQGDEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNNVGHFQKVLTAIGNFCICSIGIGMLIEIIIMYPIQHRKYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLIEVFSKDVDKDYVILLSARASRVENQDAIDTSIVNMLGDPKEARAGITEVHFLPFNPVEKRTAITYIDTNGEWHRCSKGAPEQIIELCDLKGETKRRAHEIIDKFAERGLRSLGVARQRVPEKDKESAGTPWEFVGLLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIGKETGRRLGMGTNMYPSSSLLENKDDTTGGVPVDELIEKADGFAGVFPEHKYEIVRKLQERKHIVGMTGDGVNDAPALKKADIGIAVDDATDAARSASDIVLTEPGLSVIVSAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLVALIWEFDFSPFMVLIIAILNDGTIMTISKDRVKPSPIPDSWKLKEIFATGVVLGTYMALVTVVFFWLAHDTTFFSDKFGVRSLQGKDEELIAVLYLQVSIISQALIFVTRSRSWSFVERPGLLLLIAFFVAQLIATLIATYAHWEFARIKGCGWGWCGVIWIYSIVTYIPLDILKFITRYTLSGKAWNNMIENRTAFTTKKDYGRGEREAQWALAQRTLHGLKPPESMFEDTATYTELSEIAEQAKKRAEVARLREVHTLKGHVESVVKLKGLDIDNLNQHYTV
Protein: Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Q9UK80)
Organism: Homo sapiens (Human)
Function: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}.
Interaction partners:
- Polyubiquitin-C
- Receptor-interacting serine/threonine-protein kinase 1
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Trans-acting T-cell-specific transcription factor GATA-3
- Histone H2A type 2-A
- Interleukin-33
- Antiviral innate immune response receptor RIG-I
- Histone H2A type 2-C
Sequence:
MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPDERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL
Protein: Forkhead box protein D3 (HNF3/FH transcription factor genesis) (Q9UJU5)
Organism: Homo sapiens (Human)
Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- Homeobox protein NANOG
- Transcription factor SOX-10
- Zinc finger protein SNAI2
- PR domain zinc finger protein 14
- Transcription factor SOX-9
- Paired box protein Pax-3
Sequence:
MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEADEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPSARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ
Protein: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) (Q9P7C3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2) with low efficiency.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Glucosidase 2 subunit alpha
- Protein OS-9 homolog
- Endosomal protein P24B
- DNA replication checkpoint protein tel2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1
Sequence:
MVKRRTVKYFLRRILALFVLCVPIYYLYTTVQRPPGYTKLKGSTRRKALIKKTFIESWTDYETYGWGKDEYYPIIKRGRNYLRKGMGWMIIDSLDTMMIMGLDEQVLRAREWVNNSLTWNQDDEEVSVFETTIRILGGLLSSYHLSQDKLYLDRAVDLADRLLAAYNTSTGLPRSNVNLGTRKSRKRTREYFVSTAESGTVQMELRYLSYLTGDPKYWITADKTMEVLLGDATWSHTGLVPITVNLITGAYVGRNIRLGSHGDSYYEYLLKQDLQLFSSGTVYRKAFDLSVDGIIEYLLNYTTPNHFAYIAELPGGLEHAQLPKMDHLVCFLPGTLMWGATNGTSLEAARTSKNWGTRQERDVKLAQELMRTCYEMYNMTATGLAPEIVFFDVDQTKNEIYSKRRDQHNLMRPETVESLFILYRITRDEIYREWGWNIFVSFLRYSRLPGRDAFTCLDSVESKKVKDQRDKTESFWFAETLKYLYLLFEDDFSILPLTNYTFNTEAHPFPNIENNMDLYTV
Protein: Ca8 protein (Carbonic anhydrase VIII) (Q568S6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADNVIEESGNYPGKDELDWGYEEGVEWGLLFPEANGEYQSPINLNSREARYDPQLLDVGLNPNYVVCRDCEVINDGHTVRIMLKSKSVVTGGPLPSDHEYELSEVRFHWGKENQRGSEHTVNFKAFPMELHLIHWNSTLFNSVEEAMGKKRGILIIALFVQVGKEHLGLKAITDVLQDLQYKGKTKIIPCFNPNTLLPDPLLRDYWVYEGSLTTPPCSENVTWILYRYPLTISQMQIEEFRRLRPHVKGAELPEGNDGMLGDNFRPTQPLSDRVVRAAFQ
Protein: Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC 2.7.11.1) (Q01389)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on this kinase. BCK1 probably phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- MAP kinase kinase MKK2/SSP33
- MAP kinase kinase MKK1/SSP32
- Protein kinase C-like 1
- Mitogen-activated protein kinase SLT2/MPK1
- GTP-binding protein RHO1
- Protein SLG1
- Regulatory protein SWI4
- RHO1 GDP-GTP exchange protein 2
- Transcription factor RLM1
- NAP1-binding protein 2
Sequence:
MPFLRKIAGTAHTHSRSDSNSSVKFGHQPTSSVASTKSSSKSPRATSRKSIYDDIRSQFPNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLILSWDPTDPDEWTMHRVTSWFKFHDFPESWILFFKKHQLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSHIRQKSASKLKSSRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTDEKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSNIKLSIPARPHSIIESNSTLTKSASPPASPSYPSIFRRHHKSSSSESSLLNSLFGSGIGEEAPTKPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKFKRKSQIGVPSPNTVAYVTSQETPSLKSNSSTATLTVQTADVNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTASFKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSFVPLNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFLKKSLFLNTSGKIYIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRSGTSSLIASTDDVSIVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAPKMVFKTSPKLELNLPDKGSKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYTKPELAPKREAPKPPANTSPQRTLSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPYKGANDVMRRLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNSKRVVSSTSAADIFEENDITFADAPPMFDSDDSDDDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSSTHSDEIFYDSQTQDKMERKMTFRPSPEVVYQNLEKFFPRANLDKPITEGIASPTSPKSLDSLLSPKNVASSRTEPSTPSRPVPPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWGTRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDKLNSSKLRITSQENKTE
Protein: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) (P45953)
Organism: Rattus norvegicus (Rat)
Function: Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:1730632, ECO:0000269|PubMed:8034667}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49748}.
Interaction partners:
- Trifunctional enzyme subunit beta, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- Carnitine O-palmitoyltransferase 2, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Enoyl-CoA hydratase, mitochondrial
- Peroxisomal bifunctional enzyme
- Peroxisomal acyl-coenzyme A oxidase 1
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Sequence:
MQSARMTPSVGRQLLRLGARSSRSAALQGQPRPTSAQRLYASEATQAVLEKPETLSSDASTREKPARAESKSFAVGMFKGQLTTDQVFPYPSVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNALKNPLGNVGLLIGEASKQLRRRTGIGSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSNPQQQELFRNFRSISKAMVENGGLVTSNPLRV
Protein: LD15002p (Purine-rich binding protein-alpha, isoform A) (Purine-rich binding protein-alpha, isoform C) (Purine-rich binding protein-alpha, isoform E) (Q95RR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDLGSGDDGISGSKYNVANMEGSSSRNDFDSSAKGGSGVEQELATKMLQIQSKRFYLDVKQNRRGRFIKVAEIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTDNLPEDGKLKSEMMIKDYRRYYLDLKENARGRFLRVSQTITRGGPRSQIALPAQGMIEFRDALTDLLEEFGANDGGFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSITIPEKCWIRFRDIFNDYCEKMKKSSDSITAEINLPTSSNSLK
Protein: Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) (G3X9J0)
Organism: Mus musculus (Mouse)
Function: Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:O60292}. Note=Detected in tricellular junctions. Colocalizes with apical F-actin. {ECO:0000250|UniProtKB:O60292}.
Interaction partners:
Sequence:
MTTYRPLPNDGVDLAASCGARSTDILPGPHPGDYTPMGFWAQNGSMPQPLGESPAATTTRPSPTTPAMPKMGVRARVADWPPKRDALREQSNPSPSQDTDGVKTTKVAHSMRNLQNGQLPSSTPASSGSRAFHRLSRRRSKDVEFQDGWPRSPGRAFLPLRHRSSSEITLSECDVEEPGDPRGTRHPGVLPLFREYGSTSSIDVQGVPEQSFFDILNEFRSEQPEARGSQNLRELLQVDPGALSGGSCGTKGDPRNGQPTKDSLQSLQPLKEKEKSRKKPVRGLGSGDTVDSSIFRKLRSSKPEGEVGRPLGETEESRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVAQRRNTTTGASAASAASAMVTLTASRAHSLGTLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGERERNVSFSRASVGSPGGSSEAHMAEPTLSTHRTNASISVLEVPKEQQRTQSRPRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKDHGPQYQYRIIFRTRELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLDLLGDKVCLKGFTKYAAQLDVKTDSTGTHSLYTTYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTENVCYSMAVTRSKDAPPFGPPIPNGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSSGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVAAQDYAQGSEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSSTIKIFYGRGDHIFLQAAEGSVEDIRDIVQRLKVMTNGWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLSHDQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNASEPKTESETTTPGGRPPYRSNAPWQWSGPASHNSLPATKWTTPATPGHAQSLSRLPKQTPVVPFRESQPLHSKRPVSFPETPFAASPAGADRVPPYRQPSGSFSTPGSATYARYKPSPERYAAAPHPLLSFDPHFMHDGMSSGDSSSGGLTSQESTMERPKPEPLWHVPAQARLSAMTGSIGSKHPSRQDAAGKDSPNRHSKGEPQYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPFSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPTKPHKPPGNIGLCGGGRESAGRPHPVDRRREVSPAPVVAGQNKGYRPKLYSSGSCTPPGLVGGSRDPPRQPSDMGSRAGYPTQVYKTASAETPRPSQLSQCSPFQLSTSVPKSFFSKQPAHNKHSTGWKRTDEPPPRPLPFTDSKKQVDTNAKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIVMDNLGPEQERDTGQSPQKSLQRTLSDESLCSGRREPSFASPASLEPGLPSDVLFTSTCTFPSSTLPARRQHQHAHPPSGAPSTTPATGNGFPEKKSAISASELSLADGRDRPLRRLDPGMMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPEIPPAHSPVHSHLSLERGPQTPRATPTMSEESPLDLTGKVYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAELFSREKKEL