wanglab/gogpt-training-data huggingface dataset:
Protein: Calphotin (Q02910)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays important roles in both rhabdomere development and in photoreceptor cell survival. Might function as a calcium-sequestering 'sponge' to regulate the amount of free cytoplasmic calcium. It binds 0.3 mole of Ca(2+) per mole of protein.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8094559}. Note=Hypodense compartment.
Interaction partners:
- Transient-receptor-potential-like protein
- Inactivation-no-after-potential D protein
- Opsin Rh3
- Guanine nucleotide-binding protein subunit beta-2
- Phosrestin-1
- Opsin Rh1
- Transient receptor potential protein
- Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme
- Protein kinase C, eye isozyme
- Fat body protein 2
Sequence:
MEPGTIPSPVSAPVAAPVTPSAVAAPVQVVSPAAVAPAPAAPIAVTPVAPPPTLASVQPATVTIPAPAPIAAASVAPVASVAPPVVAAPTPPAASPVSTPPVAVAQIPVAVSAPVAPPVAATPTPVAPIPVAAPVIATPPVAASAPTPAAVTPVVSPVIATPPVVPANTTVPVAAPVAAVPAAVPVVAPVLAPAVAPAVAPVVAETPAPPPVAEIPVATIPECVAPLIPEVSVVATKPLAAAEPVVVAPPATETPVVAPAAASPHVSVAPAVETAVVAPVSASTEPPVAAATLTTAPETPALAPVVAESQVAANTVVATPPTPAPEPETIAPPVVAETPEVASVAVAETTPPVVPPVAAESIPAPVVATTPVPATLAVTDPDVTASAVPELPPVIAPSPVPSAVAETPVDLAPPVLPPVAAEPVPAVVAEETPETPAPASAPVTIAALDIPEVAPVIAAPSDAPAEAPSAAAPIVSTPPTTASVPETTAPPAAVPTEPIDVSVLSEAAIETPVAPPVEVTTEVAVADVAPPEAAADLIIEPVEPPAPIPDLLEQTTSVPAVEAAESTSSPIPETSLPPPNEAVASPEVAVAPITAPEPIPEPEPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTSIPETTVEYPVAEKVLDPAITEAPVTTQEPDVANINDGAPATEITTPAVEIVTAAAEVSDTAIPLIDPPVPQEIAVAEIPETETKPAEVIVEQSTIPIEAPVPEVSKYAEPVISEAPAAEVPITAGDNPDNTSVGISEVVPTIAEKAVEEVPTSEIPEQSSSPSDSVPVAKITPLLRDLQTTDVSLLAIAATLDAIGEKLKDQKARNQQVMDRLCEIEKILGPPKSN
Protein: Anthrax toxin receptor (A4QP34)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTKENLWSVATTATLFFCLCFSSFKAETPSCHGAYDLYFVLDRSGSVSTDWSEIYDFVKNLTERFVSPNLRVSFIVFSSRAEIVLPLTGDRSEINKGLKTLSEVNPAGETYMHEGIKLATEQMKKEPKKSSSIIVALTDGKLETYIHQLTIDEADSARKYGARVYCVGVKDFDEEQLADVADSKEQVFPVKGGFQALKGIVNSILKQSCTEILTVEPSSVCVNQSFDIVLRGNGFAVGRQTEGVICSFTVDGVTYKQKPTKVKIDYILCPAPVLYTVGQQMEVLISLNSGTSYITSAFIITASSCSDGTVVAIVFLVLFLLLALALMWWFWPLCCTVVIKDPPPQRPPPPPPKLEPDPEPKKKWPTVDASYYGGRGAGGIKRMEVRWGEKGSTEEGARLEMAKNAVVSIQEESEEPMVKKPRTPAQTCHQSESKWYTPIRGRLDALWALLRRQYDRVSVMRPTSADKGRCMNFSRTQH
Protein: Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] (Q64428)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P40939}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P40939}. Note=Protein stability and association with mitochondrion inner membrane do not require HADHB. {ECO:0000250|UniProtKB:P40939}.
Interaction partners:
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Sequence:
MVASRAIGSLSRFSAFRILRSRGCICHSFTTSSALLSRTHINYGVKGDVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGADINMLASCTTPQEAARISQEGQKMFEKLEKSPKPVVAAISGSCLGGGLELAIACQYRIATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVDPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLMEKLTSYAMTIPFVRQQVYKTVEEKVKKQTKGLYPAPLKIIDAVKTGLEQGNDAGYLAESEKFGELALTKESKALMGLYNGQVLCKKNKFGAPQKTVQQLAILGAGLMGAGIAQVSVDKGLKTLLKDTTVTGLGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLAVKHKVLKEVESVTPEHCIFASNTSALPINQIAAVSQRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDALTTGFGFPVGAATLADEVGIDVAQHVAEDLGKAFGERFGGGSVELLKLMVSKGFLGRKSGKGFYIYQSGSKNKNLNSEIDNILVNLRLPAKPEVSSDEDIQYRVITRFVNEAVLCLQEGILATPEEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAYGTQFTPCQLLRDLANNSSKKFYQ
Protein: CBL-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (SNF1-related kinase 3.17) (SOS2-like protein kinase PKS12) (Q2V452)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the resistance to some abiotic stresses (e.g. high salt, hyperosmotic stress) in young seedlings, by regulating the expression of several stress-inducible genes (cold- and salt-induced genes but not drought-responsive genes). Required for the ABA response during germination. CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. The CBL9/CIPK3 complex acts in the regulation of abscisic acid response in seed germination.
Interaction partners:
- Calcineurin B-like protein 3
- Calcineurin B-like protein 2
- Calcineurin B-like protein 9
- Calcineurin B-like protein 1
- Calcineurin B-like protein 4
- Calcineurin B-like protein 10
- Ethylene-responsive transcription factor ABR1
Sequence:
MNRRQQVKRRVGKYEVGRTIGEGTFAKVKFARNSETGEPVALKILDKEKVLKHKMAEQIRREIATMKLIKHPNVVQLYEVMASKTKIFIILEYVTGGELFDKIVNDGRMKEDEARRYFQQLIHAVDYCHSRGVYHRDLKPENLLLDSYGNLKISDFGLSALSQQVRDDGLLHTSCGTPNYVAPEVLNDRGYDGATADMWSCGVVLYVLLAGYLPFDDSNLMNLYKKISSGEFNCPPWLSLGAMKLITRILDPNPMTRVTPQEVFEDEWFKKDYKPPVFEERDDSNMDDIDAVFKDSEEHLVTEKREEQPAAINAFEIISMSRGLNLENLFDPEQEFKRETRITLRGGANEIIEKIEEAAKPLGFDVQKKNYKMRLENVKAGRKGNLNVATEIFQVAPSLHMVQVSKSKGDTLEFHKFYKKLSNSLEQVVWTNNEVKKETAK
Protein: Disease resistance protein RPV1 (NAD(+) hydrolase RPV1) (EC 3.2.2.6) (Resistance to Plasmopara viticola protein) (MrRVP1) (V9M2S5)
Organism: Vitis rotundifolia (Muscadine grape)
Function: Disease resistance (R) protein that confers resistance to multiple powdery and downy mildew by promoting cell death. Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death.
Subcellular location: Nucleus {ECO:0000269|PubMed:24033846}. Cytoplasm {ECO:0000269|PubMed:24033846}.
Interaction partners:
Sequence:
MASTSSFRASSSSSTPSIPRTTTYDVFLSFRGEDTRYNFTDHLYSALGRRGIRTFRDDRLRRGEAIAPELLKAIEESRSSVIVFSENYAHSRWCLDELVKIMECQKDLGHAVFPIFYHVDPSHVRKQEGSFGEAFAGYEENWKDKIPRWRTALTEAANLSGWHLLDDRYESNQIKEITNSIFRQLKCKRLDVGANLVGIDSHVKEMILRLHLESSDVRMVGIYGVGGIGKTTIAKVIYNELSCEFEYMSFLENIREGSNPQVLFHLQNQLLGDILEGEGSQNISSVAHRASMIKDILLSRRVFIVLDDVDDLSQLEYLLGHREWLGEGSRVIITTRNKHVLAVQEVDDLYEVEGLNFEEACELFSLYAFKQNLPKSDYRNLTCRVVGYCQGLPLALKVLGSLLCKKTIPQWEGELKKLDSEPKADIHKVLKRSYDGLDRIDKNIFLDLACFFKGEGRDFVLRILDGCDFPAETGISNLNDLCLITLPYNQICMHDLIQQMGWEIVRENFPVEPNKWSRLWDPCDFERALTADEGIKSVETMSLDLSKLKRVCSNSNVFAKMTKLRLLKVYSSSDIDSAHGDSDEDIEEVYDVVMKDASKMQLGQSFKFPSYELRYLRWDGYPLDSLPLNFDGGKLVELHLKCSNIKQLWQGHKDLERLKVIDLSYSRKLSQMSEFSSMPNLERLCLSGCVSLIDIHPSVGNMKKLTTLSLRSCNKLKNLPDSIGDLESLESLYLSNCSKFEKFPEKGGNMKSLTELDLKNTAIKDLPDSIGDLESLESLYLSNCSKFEKFPEKGGNMKSLTELDLKNTAIKDLPDSIGDLESLEILNLSDCAKFEKFPEKGGNMKSLKELDLQNTAIKDLPDSIGDLKSLKYLSLSDCSKFEKFPEKGGNMKRLLQLILSNTAIKDLPDSIGDLESLKYLYLSDCSKFEKFPEKGGNMKSLTELDLKNTAIKDLPDSIGDLESLEILNLSDCAKFEKFPEKGGNMKSLKELDLQNTAIKDLPDSIGDLESLKYLYLSDCSKFEKFPEKGGNMKSLLQLILSNTAIKDLPDSIGDLESLEYLHLSVCSKFEKFPEKGGNMKSLRELGLRNTAIKDLPDSIGDLESLEMLSLSNCPKFEVLPLSLKAIDAHLCTSKEDLSRLLWLCHRNWLKSTTEEFDRWQLSAFIPESSGIPEWITYQNLGSEVTEKLPINWCEDPDFPGFVLSCVYRPSCDYSSAYIFCHDFKCELNLHGNGFRFRDVCYHECWCDCHVNFKDSRDLVCVYWYPKTAIPEEDHHKYTHINASFKSDEVKIKKCGINVIFLGDQRNHMPMLEHPQNSGDNGSALQDANGNVHGANQDDEHYHIPLLDLLRNLSLGDNGSVVLEDTLGNRKRRRNDSLPDVVEEPLYKRLGGPHTEISL
Protein: Ascus wall endo-1,3-alpha-glucanase (Endo-1,3-alpha-glucanase agn2) (Glucan endo-1,3-alpha-glucosidase agn2) (EC 3.2.1.59) (O94510)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Promotes the release of ascospores from asci by hydrolyzing 1,3-alpha-glucan in the ascus wall.
Subcellular location: Ascus epiplasm {ECO:0000269|PubMed:15194814, ECO:0000269|PubMed:19542306}.
Interaction partners:
- Ascus wall glucan endo-1,3-beta-D-glucosidase
- Zinc metalloprotease mde10
Sequence:
MASLTTALPNKAVVAHFMMGLTYNYAQSDFQNDIQNAISLGLDGFVLNFGNDSWMMSKLTLMYNAADALNLQFLLYLNLDMSEMSTVPASTLVTYVQTFANRGHQARINNNVVVGTFLGQDINFGQSSVNQGWQVAFKNALASAGINIFFMPTWPLDASTIYQTYPVADGFCKWNCWPYYTSSPTSDAEDLVYIQNSKATNKKYMATVSPIFYTHFTSKNYSFFSEGLWFTRWMQLIKDQPNYVQVLTWNDYGESTYIGPTNYAADFPVIGSNSHEWVDSFTHAPLSYSLPLFIQMYKQNTTGLPSNFSGISQLYVTYRVHSKNATASSDSIPRPDNYQNSSDVISVISFAKSSYTLRVSVNGTVLGTTNVNAGVQSANVSFIVNNTAAAGLPLFQILNGTTVIAQGYGPLNILGNNSVVLYNFNFCTTRISW
Protein: N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) (Q9QZ08)
Organism: Mus musculus (Mouse)
Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Also has N-acetylmannosamine (ManNAc) kinase activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
Interaction partners:
- Glucosamine 6-phosphate N-acetyltransferase
- Phosphoacetylglucosamine mutase
- N-acylglucosamine 2-epimerase
- N-acetylglucosamine-6-phosphate deacetylase
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- Chitinase-like 6
- Acidic mammalian chitinase
- Chitotriosidase-1
- Glutamine--fructose-6-phosphate aminotransferase 1
Sequence:
MAALYGGVEGGGTRSKVLLLSEDGQILAEADGLSTNHWLIGTDQCVERINEMVDRAKQKAGVDPLVPLRSLGLSLSGGEQEDAVRLLIEELRHRFPNLSENYLITTDAAGSIATATPDGGIVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGHVKQAMFDYFQVPDRLGILTHLYRDFDKCKFAGFCQKIAEGAHQGDPLSRYIFRKAGEMLGRHVVAVLPEIDPVLFQGELGLPILCVGSVWKSWELLKEGFLLALTLGREQQAQNSFSSFTLMKLRHSSALGGASLGARHIGYHLPMDYSINAIAFYSYTF
Protein: Transcription factor RFX3 (Regulatory factor X 3) (P48381)
Organism: Mus musculus (Mouse)
Function: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (By similarity). Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858, ECO:0000269|PubMed:19671664}.
Interaction partners:
- Forkhead box protein J1
- Serine/threonine-protein kinase ATR
Sequence:
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQVTGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESETDEDLDDSSEPRAKREKTELSQAFPVGCMQPVLESAVQPSLLNPLHSEHIVTSTQTIRQCSATGNTYTAV
Protein: Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) (Grey-lethal protein) (Q8BGT0)
Organism: Mus musculus (Mouse)
Function: Required for osteoclast and melanocyte maturation and function.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:12627228, ECO:0000269|PubMed:16525474}; Single-pass type I membrane protein {ECO:0000269|PubMed:12627228, ECO:0000269|PubMed:16525474}. Note=Requires CLCN7 to travel to lysosomes.
Interaction partners:
- H
- H
- V-type proton ATPase subunit a
- Pleckstrin homology domain-containing family M member 1
- Sorting nexin-10
- H
- H
Sequence:
MARDAELARSSGWPWRWLPALLLLQLLRWRCALCALPFTSSRHPGFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNIGNTSEGPRCGGSLLTADRMQIVLMVSEFFNSTWQEANCANCLTNNGEDLSNNTEDFLSLFNKTLACFEHNLQGHTYSLLPPKNYSEVCRNCKEAYKNLSLLYSQMQKLNGLENKAEPETHLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENAT
Protein: Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) (Q9ESN4)
Organism: Mus musculus (Mouse)
Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production.
Subcellular location: Secreted {ECO:0000269|PubMed:21378161}.
Interaction partners:
- Adhesion G protein-coupled receptor B3
- Glutamate receptor ionotropic, kainate 4
Sequence:
MVLLLVILIPVLVSSAGTSAHYEMLGTCRMVCDPYGGTKAPSTAATPDRGLMQSLPTFIQGPKGEAGRPGKAGPRGPPGEPGPPGPVGPPGEKGEPGRQGLPGPPGAPGLNAAGAISAATYSTVPKIAFYAGLKRQHEGYEVLKFDDVVTNLGNHYDPTTGKFTCSIPGIYFFTYHVLMRGGDGTSMWADLCKNNQVRASAIAQDADQNYDYASNSVVLHLEPGDEVYIKLDGGKAHGGNNNKYSTFSGFIIYAD
Protein: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (F6NHI0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating
- Glucose-6-phosphate isomerase
- 6-phosphogluconolactonase
- Glucose-6-phosphate isomerase
- GDH/6PGL endoplasmic bifunctional protein)
- Hexokinase 2.
- Hexokinase 1.
- Glyceraldehyde-3-phosphate dehydrogenase
- Hexokinase-2
- Phosphoglucomutase 1
Sequence:
MMGSRASADKMSLPLSRSEVFGQLRKELHDDTAFHQSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIRIACMPYMKVVDNEAERLAAFFSRNSYISGKYVEESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSEELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGEGEAKLGYLDDKTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVGFRYEGTYKWVNPHKL
Protein: Mrs7p (A0A1D8PCG9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
- Sodium/hydrogen exchanger
Sequence:
MNFLIRNTIIGQTCNSKQIFYKHARTLAIKSSLTSSIRYPLQPSLHNNLNANTINFPLVKSFIRHNSSKPQKSLSSPEQIKEKALETLEKSPATELVHKTAEEPKKSIWEKVKHEAKHYWDGTKLLGYEVKVSTKLLLKLMAGYELSRRESNQLQRTIVDVVRLVPFAMFVIIPFAELLLPIALKIFPNLLPSTYESTVDRQKKLAKLKKTRKAASEFIKNTMAESGGLKLSKKITDQERENFVQFFHCISMGKNPDRQQLIQVARLFKNDQVLDNLSRPQLVAMCNYMNLRPFGTDSILRYQIRHRLLNIIKDDKVIDYEGVDSLSILELQLACSQRGIKTSDKSPARLRDDLETWLDLRLRQKIPSTLLILSSAYTYGDKGNSIESYYDALLAVLSSIPDEVYNVAKLELSDDSKLKLNILKEQEEMIEEENEREKDTVTKVKDKIKLDDYEETASEGIKIEADDPVEGKNGNETQKKEESSSTKESNQDKVSTSKEPTKKEEVKV
Protein: Protein phosphatase 2C 70 (AtPP2C70) (EC 3.1.3.16) (Kinase-associated protein phosphatase) (Protein ROOT ATTENUATED GROWTH 1) (P46014)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dephosphorylates the Ser/Thr receptor-like kinase RLK5. May function as a signaling component in a pathway involving RLK5. Binds and dephosphorylates CLAVATA1 (CLV1). Functions as a negative regulator of the CLV1 signaling in plant development. Dephosphorylates SERK1 receptor kinase on threonine residues in the A-loop. Dephosphorylation of SERK1 controls SERK1 internalization. Component of a signaling pathway which mediates adaptation to NaCl stress. Is not a component of the SALT OVERLY SENSITIVE (SOS) pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12101128}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Receptor protein kinase CLAVATA1
- Somatic embryogenesis receptor kinase 1
- Cell division control protein 48 homolog A
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Protein phosphatase 2C 29
- Glycine-rich protein 3
- Protein BRASSINOSTEROID INSENSITIVE 1
- FHA domain-containing protein At4g14490
- Wall-associated receptor kinase 1
- Probable protein phosphatase 2C 66
Sequence:
MAMIGMNIIGLFMVLMLLLISLIILFACKPWRYFSRFRSSSRFSSTFKVGDLQRPLISDDGNLIQGQTSEVTREYDLEGACYQNDGLLHSSLTEGRFYKQRLPSSSPHFSQGESFVLEVISEPSDNALVGQTLKLPAEKGSLAEVQTYDWQNNRNENLQYNLEKDRLINLSPRLVEDQRSWLFLEVIAGPAIGLQHAVNSTSSSKLPVKLGRVSPSDLALKDSEVSGKHAQITWNSTKFKWELVDMGSLNGTLVNSHSISHPDLGSRKWGNPVELASDDIITLGTTTKVYVRISSQNEFQIPFKIGVASDPMAMRRGGRKLPMEDVCHYKWPLPGANKFGLFCVCDGHGGSGAAQSAIKIIPEVLANILSDSLRKEKVLSKRDASDVLRDMFAKTEARLEEHQYEGCTATVLLVWKDNEENFFAQCANLGDSACVIHLGGRYIQMTEDHRVVSLSERKRFQEAGLALRDGETRLFGINLARMLGDKFPKQQDSRFSAEPYISEPLRIDQSSKDVFAVLASDGLWDVVSPKKAVQLVLQMRDKERGRESSAEKIANGLLNEARAMRTKDNTSIIYLDFDTSL
Protein: GM04208p (Q8T3N6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQLFQHIPFLNKHFGTVDQILDEWKNYKLSVPTYGAILVSEDHNHCLLVQSYFARNSWGFPKGKINENEDPAHCATREVYEETGFDITDLIDANDYIEAFINYQYTRLYVVRNIPMDTQFAPRTRNEIKCCDWFRIDALPVNKNDAISKAKLGKTSNSFFMIMPFVKRLKKWVNDRKAGIEPRRRKFSGQQSPKAASPTNMNGNCKKDVTGVRNESQRQRHKSMGDLDGVKLNNLNGKGTVGTGAGSAASASATAAINSMNICNSNGKRNKQNAAAGSNQATPTTIATPMTSNGAVVGGTVSSKRQLFHSQSQNDAQQSASNEKIVSSFDLIRKEKQQQLKAAKAQKQQQQQQQRSRTKSQSDKQYNPQQPVKILGQQQPTTGMDLIAMLSAAAAAQKTPNNEQQTQEKQQQQQRPRPASVSLNLGAGSATGATTSAPDAQYMHRLQRMASGTNLRILKRAQSQQPQQHHQQQLQLEQQQQQQQQLGIDFTPNLNSWTNFSFTKNFIANVFC
Protein: Microtubule-associated protein 1 light chain 3 beta (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (Microtubule-associated proteins 1A/1B light chain 3B) (MAP1A/MAP1B LC3 B) (MAP1A/MAP1B light chain 3 B) (Q9CQV6)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy.
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12207896}; Lipid-anchor {ECO:0000250|UniProtKB:Q9GZQ8}. Endomembrane system {ECO:0000269|PubMed:12207896}; Lipid-anchor {ECO:0000250|UniProtKB:Q9GZQ8}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9GZQ8}; Lipid-anchor {ECO:0000250|UniProtKB:Q9GZQ8}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:12207896}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9GZQ8}. Note=LC3-II binds to the autophagic membranes. LC3-II localizes with the mitochondrial inner membrane during Parkin-mediated mitophagy (By similarity). Also localizes to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q9GZQ8}.
Interaction partners:
- Ubiquitin-like-conjugating enzyme ATG3
- Next to BRCA1 gene 1 protein
- Sequestosome-1
- FUN14 domain-containing protein 1
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Ubiquitin-like modifier-activating enzyme ATG7
- Calcium-binding and coiled-coil domain-containing protein 2
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- FYVE and coiled-coil domain-containing protein 1
Sequence:
MPSEKTFKQRRSFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESERDEDGFLYMVYASQETFGTAMAV
Protein: Actin-related protein 2 (Actin-like protein 2) (P61160)
Organism: Homo sapiens (Human)
Function: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9000076}. Cell projection {ECO:0000269|PubMed:9000076}. Nucleus {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29925947}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 3B
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 2/3 complex subunit 4
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
- Actin-related protein 2/3 complex subunit 5
Sequence:
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR