wanglab/gogpt-training-data huggingface dataset:
Protein: At1g29530 (Q6NL08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AWPM-19-like family protein
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- 25S rRNA
- Secreted protein
- Pentatricopeptide repeat-containing protein At5g10690
- Flowering time control protein FPA
Sequence:
MPSGAKKRKALKKKKQQEAIGTSINGNDEHGSQDGRGSDSSLSSPGSQGNQEFGTKDSSALLSSAVVKGASKEISRDAGVTQGLGPKTGNAIVEKSTNSSSDNRTRPAKNVACGNSVTEITPVVDSVKPVVSISKTVTSEKSGLVETSTHSNLVKKKSEKDEEYHPSPVLENNNSKVVMLPRSAPETSKKVESVRKSEVPVSPEEKPLLLPGPPVVRRTSWLSCCGLFDAMTGSDR
Protein: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9) (P63078)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- C-X-C chemokine receptor type 4
- 5-hydroxytryptamine receptor 7
- Ras-specific guanine nucleotide-releasing factor 1
- C-C chemokine receptor type 5
- Melatonin receptor type 1B
- Apelin receptor
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Sequence:
MSNNMAKIAEARKTVEQLKLEVNIDRMKVSQAAAELLAFCETHAKDDPLVTPVPAAENPFRDKRLFCTLL
Protein: Kinesin-like protein (Q502K6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
Sequence:
MALASPCGILSDEEECGAVFESTAADVVGLMRSQRFVSPLPEISVITPAADSLTPTKELVQIKSDISRRGSTDDGSDKLKVFLRIRPLTEAEKDRGEEQGCVNVQSEDNLLLKAPKDSRNMKSAERGVAQSVHKFTFTKIFGPQTSQQEVYDHTIREMARDVLRGENRLLYTYGVTNSGKTYTIQGAGAEAGLLPRALVSVFLKLSGRLYTAMDLKPVLSQEVRKLDVGEVRAEEMRRDALLKEDESNQSRLRAGLSWDSGISGLSATSHIATQLEDSDGVCLEANGLCLSGGEDLEEGVQFSVWVSFYEIYNEFLYDLLDAPPSLQSRKRVTLRLSDDKHGNPYVKDLTWIQVHSAEEAWKVLKVGQRNQSFASTHLNHNSSRSHSIFTIRVLHVKPQLGQVTRISELSVCDLAGSERCKAQQNGERMKEANNINTSLLTLGRCITALRHNQTNKSRPPVVVPFRDSKLTRVLQSFFCGHGRSCMVVNINPCASTYDETLQALKFSAFATQLVHGPCSKTRVAYILSLLREQPTHPNDTTLLEEDEEESDEEGDITMFDPEALLKAIDVLKREVLRQRQEKEELEAKVREEVCTEMMEVISRMQDDFSETLESERDLMEKRCENKINNLKSSLKKYYSQELEERDDEIRELTAALKEKEAGNTAPAAIFPPLNDDGGLRRSQRLASTHKRDADHESIELFRCKAELENCRAELDLKQTELRLKTLELKRFQDNLPSMGVTGTLTTTAERKLEEGQRNLKQLRMELQLLGIKLQSGERACCRNTDGEKLRHALSSADSKLAKQDQMLVELHTSLQLVKAELRKKDELLTRFQNTQQAQSHQPPTASGSCKKRGCGVAVALAENQPPEKRPFFRSLFPSRTPSKTPSRPTRQQNEVTTPYSRVLRSRQPSPPTTPVMLRVKY
Protein: Collagen alpha3(VI) (Q9Z0I9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRKHRHLPLVAVFSLLFSGIAMTRAQQHGDVKNGAAADIVFLVDSSWSAGKDRFLLVQEFLSDVVESLAVGDNDFHFALVRLNGNPHTEFLLNTYHSKQEVLSHIANMSYIGGSNQTGKGLEYVIHSHLTEASGSRAADGVPQVIVVLTDGQSEDGFALPSAELKSADVNVFAVGVEGADERALGEVASEPLSMHVFNLENVTSLHGLVGNLVSCIHSSVNPERAGDKESLKDITAQDSADIIFLIDGSQNTGNANFDVIRDFLVNVLERLSVGNQQVQVGVVQYSEEPITMFSLNSYPSKAAVLDAVKGLSLVGGESANIGQALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRDSVVALKQASVFSFGLGAQAASRAELQHIATDDSLVFTVPEFRSFGDLQEQILPYLVGVAQRHIVLQPPAIVTQVMEVNKRDIVFLVDGSSSLGPSNFNAIRDFVTRVIQRLEIGQDLVQVSVAQYADTVKPEFYLNSYTNKRDAVTAVRKMRALNGSALYTGSSLDFVRNNLFTSSAGHRAAEGVPKLLVLITGGKSLDEVSQPAQELKRGSIMALAVGSKAADEDELKEIAFDSSLVFIPAEFRPAPLQNMLPSLMAPLRTLTGTTEVHVNKRDIIFLLDGSDNVGKNNFPYVRDFVTNLVNSLDVGSDNIRVGLVQFSDTPVTEFSLDTYQTKSELLAHLRRLQLKGGSGLNAGSALSYIHANHFTEAGGSRTREHVPQLLLLLMAGPSEDAYLQAANALVRSGVLTFCVGTNRADKAELEHIAFNPSLVYLMDDFRSLPSLPQQLIQPLTTYVSGGVQEVPLSQPESKRDILFLFDGSVNVLGQFPAVRDFLYRIIEELDVKPDGTRVAIAQFSDDVRLESRFSEHQTKAEILNLVKKMKLKTGKALNLGYALDYALRNIFVRSAGSRIEDNVQQFLVLLVAGRSSDAVAGPASSLKQRGVVPFIFQAKNANPSELEQIVLSPAFILAAESLPKIGDLQSQIVSLLKAEQGSGPVSGEKDVVFLIDGSEGVRSGFPLLKDFVQRVVESLDVGPDRVRVALVQYSDRTRPEFYLNSHMDQQGVISAIRRLTLLGGPTPNTGAALEFVLRNILTSSTGSRIAEGVPQLLIVLTAEPSGDDVRGPSVVLKQGGAVPIGIGIGNADISEMQTISFIPDFAVAIPTFRELGTIQQVISERVIQLNREELSSLKPILTPSTGAGVGSKKDVVFLIDGSRNAGPEFQYIRTLIERIVEYLDIGFDTTRVAVIQFSEDSKMEFPLNAHFSKDEVQNAVRRLRPKGGSQVYIGNALEYVLKNIFQRPLGSRIEEGVPQFLVLISSGKSDDEVDDSAVELKQFGVAPLTIARHTDQEELVKISLSPEYVYSVSTFRELPRLEQKLLKPITTLTSQQIHQILASTRYPPSVVESDAADIVFLIDSSDAVKPDGIAHIRDFVSRIVRRLNIGPSKVRIGVVQFSNDVFPEFYLKTHKSQSSVLEAIRRLRFKGGSPLNTGRALEFVARNLFVKSAGSRIEDGVPQHLVLFLGGKSQDDVARHAQVISSSGIVSLGIGDRNIDRTDLQTITNDPRLVFTVREFRELPNIEERVMLSFGPSGATPQPPGVDLPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFASEIVDTVYEDGDSIRVGLVQYNSDPTDEFFLRDFSTKRQIIDAI
Protein: Pre-mRNA-splicing factor 18 (Q9SA55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8A
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor SLU7-A
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor SLU7-B
- Pre-mRNA-processing-splicing factor 8B
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7
- Cwf15 / Cwc15 cell cycle control family protein
- Transducin/WD40 repeat-like superfamily protein
- Pre-mRNA-processing factor 17
Sequence:
MDLLREEILKKRKSLAEESGGKKFFKRSEIEQKKIQKLREEERREHELKAQRRAAAAASGGDGKSSGSAPGSSNAATSASSKSSASDAAAIADSKALTDENLILPRQEVIRRLRFLKQPMTLFGEDDQSRLDRLKYVLKEGLFEVDSDMTEGQTNDFLRDIAELKKRQKSGMMGDRKRKSRDERGRDEGDRGETREDELSGGESSDVDADKDMKRLKANFEDLCDEDKILVFYKKLLIEWKQELDAMENTERRTAKGKQMVATFKQCARYLVPLFNLCRKKGLPADIRQALMVMVNHCIKRDYLAAMDHYIKLAIGNAPWPIGVTMVGIHERSAREKIYTNSVAHIMNDETTRKYLQSVKRLMTFCQRRYPTMPSKAVEFNSLANGSDLQSLLAEERFFGGNREQVSEERLRLMPSQSES
Protein: Forkhead box N1 (A0A8I6GMI6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MVSLLPPHSDVTLPGSTRLEGEPQGDLMQAPGLPGSPAPQNKHANFSCSSFVPDGPPERAPSLPPHSPSVASPGPEQIQSHCTAGPGPGSFRLSPSDKYPGFGFEEGPAGSPGRFLRGNHMPFHPYKGHFHEDIFSEAQTAMALDGHSFKTQGALEAFEEIPVDVGDAEAFLPSFPAEAWCNGLPYPSQEHNQVLQGSEVKVKPQALDNGPGMYCYQPPLQHVYCSSQPTFHQYSPGGGSYPVPYLGSTHYPYQRIAPQANADGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPSKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKLGSPLLGCPPPGLAGPGPIRPLAPSAGLTQPLHPMHPAPGPMPGKNPLQDLLGGHAPSCYGQTYPHLSPSLAPSGHQQPLFSQPDGHLDLQAQPGTPQDSPLPAHTPPSHGAKLLAEPSSARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMLPPPPAAHCFPPGPCLAETGNEAGELAPPGSGGSGALGDMHLSTLYSAFVELEPTPSSAAASTAVYLSPGSKPMALA
Protein: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta) (Q84LB6)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03219, ECO:0000269|PubMed:16270230}.
Interaction partners:
- Succinate--CoA ligase subunit alpha-2, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate--CoA ligase subunit alpha-1, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- THH1/TOM1/TOM3 domain-containing protein
- Uncharacterized protein
- Dihydrolipoyl dehydrogenase
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Dihydrolipoyl dehydrogenase
Sequence:
MLRKLANQSLSVAGKWQQQQLRRLNIHEYQGAELMSKYGINVPKGVAVASLDEVKKAIQDVFPNQSEVVVKSQVLAGGRGLGTFKNGFQGGVHIVKADQAEDIASKMLGQILVTKQTGAQGKVVSKVYLCEKMSLVNEMYFSIILDRATAGPLIIACRKGGTSIEDLAEKFPDMIIKVPIDVFKGISDADAAKVVDGLAPKVADRNDSIEQVKKLYKLFCETDCTMLEINPLAETSDNKLVAADAKLNFDDNAAYRQKEIFSLRDSSQEDPREVAAAKADLNYIGLDGEIGCMVNGAGLAMATMDIIKLHGGTPANFLDVGGNATEGQVVEAFKILTADEKVKAILVNIFGGIMKCDVIASGIVNAAKQVQLKVPVIVRLEGTNVEQGKRILKESGMKLITAEDLDDAAEKAVKALA
Protein: Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] (Q9H078)
Organism: Homo sapiens (Human)
Function: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Plays a role in granulocyte differentiation.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:25597510, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32866687, ECO:0000269|PubMed:34115842}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- GrpE protein homolog 1, mitochondrial
- ATP-dependent clpX-like chaperone, mitochondrial
- 10 kDa heat shock protein, mitochondrial
- Heat shock 70 kDa protein 4
- 60 kDa heat shock protein, mitochondrial
- DnaJ homolog subfamily B member 1
- GrpE protein homolog 2, mitochondrial
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
Sequence:
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGRLPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLDIRAPLHPEKVCNTI
Protein: Zinc finger protein ZPR1 (Zinc finger protein 259) (Q62384)
Organism: Mus musculus (Mouse)
Function: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (By similarity). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.
Subcellular location: Nucleus. Cytoplasm. Nucleus, nucleolus. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus, gem. Nucleus, Cajal body. Cell projection, axon. Cell projection, growth cone. Note=Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner (By similarity). Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons. {ECO:0000250}.
Interaction partners:
- BUD13 homolog
- Epidermal growth factor receptor
- Apolipoprotein A-V
- DnaJ homolog subfamily C member 2
- Elongation factor 1-alpha 2
- Elongation factor 1-alpha 1
- Rhodopsin
Sequence:
MSASGAVQPGHPGAAVGPSPAAAASPATGPLFRPLSAEDEEQQPTEIESLCMNCYRNGTTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVRYTLTVRSQEDMNREVVKTDSATTRIPELDFEIPAFSQKGALTTVEGLISRAISGLEQDQPTRRAVEGAIAERIDEFIGKLKDLKQMASPFTLVIDDPSGNSFVENPHAPQKDNALVITYYDRTPQQAEMLGLQAEAPEEKAEEEDLRNEVLQFNTNCPECNAPAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDPSDMTRDLLKSETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPDQSEKLQEFSQKLGQIIEGKMKAHFIMNDPAGNSYLQNVYAPEDDPEMKVERYKRTFDQNEELGLNDMKTEGYEAGLAPQR
Protein: At1g73940/F2P9_19 (Tumor necrosis factor receptor family protein) (Q9C9B5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein
- Small ribosomal subunit protein bS16m/bS16c
- Putative ribosomal protein L6
- Large ribosomal subunit protein mL53
- Large ribosomal subunit protein mL46
- Ribosomal protein L18e/L15 superfamily protein
- Small ribosomal subunit protein uS13m
- Small ribosomal subunit protein mS33
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Uncharacterized protein At1g27435/F17L21.30
Sequence:
MWFAGGGGGLRKLCRASAIFDNEISYNSLLVRYMSRERAVNVRKINPKVPIQEAYAISNSLYDLFKLHGPLSVPNTWLRAQEAGVSGLNSKTHMKLLLKWMRGKKMLKLICNQVGSSKKFFHTVLPEDPLQEQPAAPIENKKQAVKKKRSK
Protein: Caspase drICE (EC 3.4.22.-) (Death related ICE-like caspase) [Cleaved into: Caspase subunit p21; Caspase subunit p12] (O01382)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.
Interaction partners:
- Death-associated inhibitor of apoptosis 1
- Caspase Dronc
- Death-associated inhibitor of apoptosis 2
- Cell death protein rpr
- Poly [ADP-ribose] polymerase
- Deterin
- Lamin Dm0
- Apoptosome protein Dark
- Caspase-8
- AT03047p
Sequence:
MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVTDRHAAEYNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEMGYIYAKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRFSDKQLAPAGRV
Protein: Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (gBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (P35331)
Organism: Gallus gallus (Chicken)
Function: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Specifically involved in the development of optic fibres in the retina.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Contactin-2
- Contactin-1
- Gliomedin.
- Semaphorin 3B.
- Semaphorin-6D
- Plexin A1.
- Uncharacterized protein.
- Ankyrin 1.
- Contactin-5
Sequence:
MMKEKSISASKASLVFFLCQMISALDVPLDSKLLEELSQPPTITQQSPKDYIVDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDAQVTMKPNSGTLVVNIMNGVKAEAYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPNHVREGDSLVLNCRPPVGLPPPIIFWMDNAFQRLPQSERVSQGLNGDLYFSNVQPEDTRVDYICYARFNHTQTIQQKQPISVKVFSTKPVTERPPVLLTPMGSTSNKVELRGNVLLLECIAAGLPTPVIRWIKEGGELPANRTFFENFKKTLKIIDVSEADSGNYKCTARNTLGSTHHVISVTVKAAPYWITAPRNLVLSPGEDGTLICRANGNPKPSISWLTNGVPIAIAPEDPSRKVDGDTIIFSAVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANKLYQVIADSPALIDCAYFGSPKPEIEWFRGVKGSILRGNEYVFHDNGTLEIPVAQKDSTGTYTCVARNKLGKTQNEVQLEVKDPTMIIKQPQYKVIQRSAQASFECVIKHDPTLIPTVIWLKDNNELPDDERFLVGKDNLTIMNVTDKDDGTYTCIVNTTLDSVSASAVLTVVAAPPTPAIIYARPNPPLDLELTGQLERSIELSWVPGEENNSPITNFVIEYEDGLHEPGVWHYQTEVPGSHTTVQLKLSPYVNYSFRVIAVNEIGRSQPSEPSEQYLTKSANPDENPSNVQGIGSEPDNLVITWESLKGFQSNGPGLQYKVSWRQKDVDDEWTSVVVANVSKYIVSGTPTFVPYEIKVQALNDLGYAPEPSEVIGHSGEDLPMVAPGNVQVHVINSTLAKVHWDPVPLKSVRGHLQGYKVYYWKVQSLSRRSKRHVEKKILTFRGNKTFGMLPGLEPYSSYKLNVRVVNGKGEGPASPDKVFKTPEGVPSPPSFLKITNPTLDSLTLEWGSPTHPNGVLTSYILKFQPINNTHELGPLVEIRIPANESSLILKNLNYSTRYKFYFNAQTSVGSGSQITEEAVTIMDEAGILRPAVGAGKVQPLYPRIRNVTTAAAETYANISWEYEGPDHANFYVEYGVAGSKEDWKKEIVNGSRSFFVLKGLTPGTAYKVRVGAEGLSGFRSSEDLFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYRSLESDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV
Protein: USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) (Q92738)
Organism: Homo sapiens (Human)
Function: Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle.
Interaction partners:
- Epidermal growth factor receptor kinase substrate 8
- Ras-related protein Rab-43
- Ras-related protein Rab-5A
Sequence:
MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSRTGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRKEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAEDGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVSNKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSPGTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNGKLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAVSVDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL
Protein: Phosphoglucomutase 1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) (P33401)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Minor phosphoglucomutase isozyme that catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate. Constitutes about 10-20% of the phosphoglucomutase activity in the cell. Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Phosphoribomutase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen phosphorylase
- Glucose-6-phosphate isomerase
- Phosphoglucomutase 2
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Hexokinase-2
- Transketolase 1
- Glucokinase-1
- Hexokinase-1
Sequence:
MSLLIDSVPTVAYKDQKPGTSGLRKKTKVFMDEPHYTENFIQATMQSIPNGSEGTTLVVGGDGRFYNDVIMNKIAAVGAANGVRKLVIGQGGLLSTPAASHIIRTYEEKCTGGGIILTASHNPGGPENDLGIKYNLPNGGPAPESVTNAIWEASKKLTHYKIIKNFPKLNLNKLGKNQKYGPLLVDIIDPAKAYVQFLKEIFDFDLIKSFLAKQRKDKGWKLLFDSLNGITGPYGKAIFVDEFGLPAEEVLQNWHPLPDFGGLHPDPNLTYARTLVDRVDREKIAFGAASDGDGDRNMIYGYGPAFVSPGDSVAIIAEYAPEIPYFAKQGIYGLARSFPTSSAIDRVAAKKGLRCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHIREKDGLWAIIAWLNILAIYHRRNPEKEASIKTIQDEFWNEYGRTFFTRYDYEHIECEQAEKVVALLSEFVSRPNVCGSHFPADESLTVIDCGDFSYRDLDGSISENQGLFVKFSNGTKFVLRLSGTGSSGATIRLYVEKYTDKKENYGQTADVFLKPVINSIVKFLRFKEILGTDEPTVRT
Protein: Fibrillin 1 (A0A8I6A897)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MRRGGLLEVALAFTLLLESYTSHGADANLEAGSLKETRANRAKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQISPSCGSRSRIIHIVLAALSGGGVQVQHHETLSPYLAAVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPGYCYTTLTNGRCSNQLPQSITKMQCCCDVGRCWSPGVTVAPEMCPIRSTEDFNKLCSVPLVIPGRPDYPPPPLGPLPPVQPVPGFPSGPVIPVPRPPPEYPYPSPSREPPKVLPFNVTDYCQLVRYLCQNGRCIPTPGSYRCECNKGFQLDIRGECIDVDECEKNPCTGGECINNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYRRGQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSECCSSLGAAWGSPCTICQVDPICGKGYSRIKGTQCEDINECEVFPGVCKNGLCVNSRGSFKCECPSGMTLDATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPLRNSREYEELCPRGPGFATKDITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNYFTFSLFWVTSPCKVVPALMLPPSVFHADIDEYINECELSANLCPSGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDINECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYTCDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCELCPPVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYHADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRLTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNADQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSTGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECAEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENGRCLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFEGTVAYKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTACVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTACIDNNECTSEINLCGSKGVCQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHVCGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSSQAPCSYGCSNTEGGYLCGCPPGYLRIGQGHCVSGMGMGRGGPEPPASGEMDDNSLSPEACYECKINGYPKRGRKRRSTNETDASDIQDGSEMEANVSLASWDVEKPASFAFNISHINNKVRILELLPALTTLMNHNKYLIESGNEDGFFKINQKEGVSYLHFTKKKPVAGTYSLQISSTPLYKKKELNQLEDRYDKDYLSGELGDNLKMKIQILLH
Protein: REST corepressor 2 (Q5FWT8)
Organism: Rattus norvegicus (Rat)
Function: May act as a component of a corepressor complex that represses transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Interaction partners:
- Lysine-specific histone demethylase
- PHD finger protein 21A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- Histone deacetylase 2
- RE1-silencing transcription factor
- Zinc finger protein 217
- Methyl-CpG-binding protein 2
- Histone deacetylase 1
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
Sequence:
MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPDTGDPKREPLPSRPLNARPGPGKKEIQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPTAPVPVEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPTLVGAQLEPPAPSL
Protein: EP1 (LY6/PLAUR domain containing 8 like) (Q6YI28)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGWSSILKSLLTVFVLSILAVCSVESYTCIQATCENGNCLGGTSTCLTSYSCFSQIQKLETPSPDTNLVLEQKGCASYQNLCALEFSATLGNRQKFRYKTQCCTGEQCNKENLTLPPLSSEVNGVECPACYNNKTNTCSTTTPLKCTGAEKRCIEVTSRDPSSNIVMYGKGCATENACALYMTVFNNIQIKTSCISTNGSPALKSAASLPVILLLQKILL