wanglab/gogpt-training-data huggingface dataset:
Protein: Type 2C protein phosphatase (Q59MW1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Type 2C protein phosphatase
Sequence:
MSTRSRQLLPPSLSFVRHVSQTVTFTAMDISSSGGFSHKQPSKVGKLIVPILKSPSHLGHSSSRVNRLYNEDKYSANLLQVKESQIFNFSIFDGHGGDQCSTYLAENLSSALEDSDQLVENDNDRQELFKKYAKNVGGYWKRWYKHRDNTVANWEKERIKLKNFLSDDLATRVPLAFLNADYNFFSKEQKSGSTCTSALIETIYSKPGTFQPFFENYYFNRHTISKLSIGHLGDTRAIVADKNGLAHTLTTDHHPSNPIEAKRLRKYAANFFMTDSFGEERFVALANTRAFGDVDYKEVGVTAEPDFNQYIIGDSDAIKQFLTPDEIEKYTIGGLGGDESFLILCSDGVTNILTDQEIADIVLTHVNLKGQTVATPQYCAEQVIKFVEFVGGDDNATCLVIRLNGWGNWPIIDRTGELRQARLDDYNPRGARG
Protein: Probable transposase (P95131)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Secreted protein
- Possible transposase
- Conserved protein
- Possible integral membrane protein
- Conserved protein
- Uncharacterized ABC transporter ATP-binding protein Rv2564
Sequence:
MEHGNPHDAPQLAPAVERITTRAGRPPGTVTADRGYGEKRVEDDLHDLGVRTVAIPRKGRPSQARRAEEQRPSFRRTVKWRTGSEGRISTLKRNYGWNRSCIDGTEGTRIWTRHGILTHNLIKISSLAA
Protein: Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) (Q15833)
Organism: Homo sapiens (Human)
Function: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
Interaction partners:
- Syntaxin-11
- Syntaxin-3
- Syntaxin-19
- Protein unc-13 homolog D
- Syntaxin-2
- Four and a half LIM domains protein 2
- Syntaxin-1A
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 2
- Lysosomal-trafficking regulator
Sequence:
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP
Protein: Protein catecholamines up (Q9V3A4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Negatively regulates tyrosine hydroxylase activity.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- LD23375p
- Zinc transporter 63C, isoform F
- Zinc/iron regulated transporter-related protein 102B, isoform E
- Zinc transporter ZIP11
- DSec61alpha
Sequence:
MAKQVADYQCSKLQLYQKLALVVILGAVLFSLPALCAGQGNPSFKYSREANENFDPQKAPRAEHHHHHDHDHDHGHHHHGHDHDHDHDHGHDHGHHHHGHDHDHDHDHGHHHHGHDERHTKAKPDLDMSTIWLHSIGSTLLISAAPFVLLYIIPLDNSEAMKPRLKVLLAFASGGLLGDAFLHLIPHATHPHSHGEHGHDHGHDHHHHHDGEEHEHGHSHDMSIGLWVLGGIIAFLSVEKLVRILKGGHGGHGHSHGAPKPKPVPAKKKSSDKEDSGDGDKPAKPAKIKSKKPEAEPEGEVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIGIVTTITILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGSAPWVLPFTAGGFIYIATVSVLPELLEESTKLKQSLKEIFALLTGVALMIVIAKFE
Protein: Proteasome subunit alpha type-1 (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) (Q9R1P4)
Organism: Mus musculus (Mouse)
Function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P25786}. Nucleus {ECO:0000250|UniProtKB:P25786}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P25786}.
Interaction partners:
- Proteasome subunit beta type-9
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-10
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-2
- 26S proteasome non-ATPase regulatory subunit 4
- Proteasome subunit beta type-5
- Proteasome subunit beta type-3
Sequence:
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLDGLEERPQRKAQPSQAAEEPAEKADEPMEH
Protein: Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein) (P20592)
Organism: Homo sapiens (Human)
Function: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.
Interaction partners:
- Interferon-induced GTP-binding protein Mx1
- Ubiquitin-like protein ISG15
- Antiviral innate immune response receptor RIG-I
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Antiviral innate immune response effector IFIT1
- 2'-5'-oligoadenylate synthase 2
- Ubl carboxyl-terminal hydrolase 18
- E3 ISG15--protein ligase HERC5
- G-patch domain and KOW motifs-containing protein
- 2'-5'-oligoadenylate synthase 1
Sequence:
MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH
Protein: Large ribosomal subunit protein P2B (60S acidic ribosomal protein P2-beta) (A4) (P17478)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an important role in the elongation step of protein synthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein eS19B
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS9A
- Small ribosomal subunit protein uS8B
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein uS15
Sequence:
MKYLAAYLLLTVGGKQSPSASDIESVLSTVGIEAEAERVESLISELNGKNIEELIAAGNEKLSTVPSAGAVATPAAGGAAGAEATSAAEEAKEEEAAEESDEDMGFGLFD
Protein: Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) (B3KTU4)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU003981}.
Interaction partners:
Sequence:
MVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
Protein: Protein FAR-RED-ELONGATED HYPOCOTYL 1-LIKE (A8MR65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Can activate transcription (By similarity). Essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes. PHYA-specific signal transducer in response to continuous FR lights. Mediates the association of PHYA with HFR1 and LAF1 in the nucleus in response to FR conditions. Contributes to inhibition of hypocotyl elongation in continuous blue light (B).
Subcellular location: Nucleus {ECO:0000269|PubMed:21884939}. Cytoplasm {ECO:0000269|PubMed:21884939}. Note=Shuttles from cytoplasm to nuclear bodies in FR but stay in the cytoplasm in other light conditions. {ECO:0000269|PubMed:21884939}.
Interaction partners:
- Phytochrome A
- ARM repeat superfamily protein
- Protein FAR-RED ELONGATED HYPOCOTYL 3
- Protein MAEA homolog
- At4g09200
- SPla/RYanodine receptor
- Ran-binding protein M homolog
- Transcription factor HFR1
- Transcription factor LAF1
- LisH and RanBPM domains containing protein
Sequence:
MDDADKSCSPSLDHSDINDPMIVAVESLDTSKKRKLHAEESDLLPLPKHFCSEHQASLVNSSCPSSVIDYAECSYAMENTKTSDEASSSASFTGPSLYMFKDSIYSTGSSSSGYAATSSIEQCFSKVDHKTQEDTQDFTHMEFIYHDSEFAVEDLQEVLNPVESYILSSARWSVSNQDSKEATTKPTIDQEFEQYFSTLMM
Protein: Mitochondrial carnitine/acylcarnitine carrier-like protein (Carnitine/acylcarnitine translocase-like protein) (CAC-like protein) (Protein A BOUT DE SOUFFLE) (Q93XM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in photorespiratory metabolism. Acts probably as a carrier for a glycine decarboxylase (GDC) cofactor or, alternatively, may act as a mitochondrial glycine shuttle. Involved in the transition from the embryonic stage to the juvenile autotrophic stage.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:12215513, ECO:0000269|PubMed:14671022}; Multi-pass membrane protein {ECO:0000269|PubMed:12215513, ECO:0000269|PubMed:14671022}.
Interaction partners:
- Phototropic-responsive NPH3 family protein NPY1
- Plastidal glycolate/glycerate translocator 1, chloroplastic
- Dicarboxylate transporter 2.1, chloroplastic
- Dicarboxylate transporter 1, chloroplastic
- Serine hydroxymethyltransferase 1, mitochondrial
- D-glycerate 3-kinase, chloroplastic
Sequence:
MADAWKDLASGTVGGAAQLVVGHPFDTIKVKLQSQPTPAPGQLPRYTGAIDAVKQTVASEGTKGLYKGMGAPLATVAAFNAVLFTVRGQMEGLLRSEAGVPLTISQQFVAGAGAGFAVSFLACPTELIKCRLQAQGALAGASTTSSVVAAVKYGGPMDVARHVLRSEGGARGLFKGLFPTFAREVPGNATMFAAYEAFKRFLAGGSDTSSLGQGSLIMAGGVAGASFWGIVYPTDVVKSVLQVDDYKNPRYTGSMDAFRKILKSEGVKGLYKGFGPAMARSVPANAACFLAYEMTRSSLG
Protein: Chemotaxis protein CheW (P0A964)
Organism: Escherichia coli (strain K12)
Function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB.
Subcellular location: Cytoplasm.
Interaction partners:
- Methyl-accepting chemotaxis protein IV
- Protein-glutamate methylesterase/protein-glutamine glutaminase
- Chemotaxis protein CheA
- Protein phosphatase CheZ
- Aerotaxis receptor
- Methyl-accepting chemotaxis protein I
- Motility protein B
- Methyl-accepting chemotaxis protein II
- Chemotaxis protein CheY
- Chemotaxis protein methyltransferase
Sequence:
MTGMTNVTKLASEPSGQEFLVFTLGDEEYGIDILKVQEIRGYDQVTRIANTPAFIKGVTNLRGVIVPIVDLRIKFSQVDVDYNDNTVVIVLNLGQRVVGIVVDGVSDVLSLTAEQIRPAPEFAVTLSTEYLTGLGALGDRMLILVNIEKLLNSEEMALLDSAASEVA
Protein: SH3 domain-containing protein 19 (Kryn) (Q91X43)
Organism: Mus musculus (Mouse)
Function: May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Clathrin interactor 1
- Pumilio homolog 1
- Serine protease 48
Sequence:
MNIMNTEQSQNTIVSRIKAFEGQTNTEIPGLPKKPEIIPRTIPPKPAVSSGKPLVAPKPAANRASGEWDTWAENRLKVTSREGLTPYSSPQEAGITPVTKPELPKKPTPGLTRSVNHETSGGRPMAESPDTGKKIPTPAPRPLLPKKSASTDAPPYPSIPPKLVSAPPRLSVASQAKAFRSLGEGLPSNPPVPAPQSKALGDIDLISFDDDVLPTSGSPAEEPTGSETVLDPFQLPTKTEATKERAVQPAPTRKPTVIRIPAKPGKCLHEEPQSPPPLPAEKPVGNTHSAVSGRPSHSDRTRNPELEQASESGGLVQGPPRLPPRPVHGKVIPVWRPPPKGAPERPPPPKLPASKSSNKNLPFNRSSSDMDLQKKQSHFVSGLSKAKSQIFKNQDPVLPPRPKPGHPLYRKYMLSVPHGIANEDIVSRNPTELSCKRGDVLVILKQAENNYLECQRGEGTGRVHPSQMKIVTPLDERPRGRPNDSGHSQKPVDSGAPHAVALHDFPAEQADDLSLTSGEIVYLLEKIDAEWYRGKCRNQTGVFPANYVKVIVDIPEGRSGKRESFSSHCAKGPRCVARFEYIGDQKDELSFSEGEVIILTEYVNEEWGRGEIRDRSGIFPLNFVELVGDHPTSGANILSTKVPPKTKNEDPGSNSQDSSPPGEWCKALHSFTAETSEDLPFKRGDRILILERLDSDWYRGRLHDREGIFPAVFVQPCPAEAKGVASAIPKGRKVKALYDFLGENEDELSFKAGDVITELEPIDDAWMRGELMGRAGMFPKNYVQFLQVS
Protein: Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1) (P01037)
Organism: Homo sapiens (Human)
Function: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
Subcellular location: Secreted {ECO:0000269|PubMed:20189825}.
Interaction partners:
- Cystatin-SA
- Serine/threonine-protein phosphatase CPPED1
- Cystatin-S
- Prolactin-inducible protein
Sequence:
MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES
Protein: Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (Q49GP5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8TCG2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TCG2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TCG2}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TCG2}. Cell membrane {ECO:0000250|UniProtKB:Q8TCG2}. Early endosome membrane {ECO:0000250|UniProtKB:Q8TCG2}.
Interaction partners:
- Phosphatidylinositol 4-kinase, catalytic, alpha a
- Phosphatidylinositol 4-kinase beta
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Synaptojanin-1
- Phosphatidylinositol-3-phosphatase SAC1-A
- Phosphatidylinositol-3-phosphatase SAC1-B
- Phosphatidylinositol 3-kinase regulatory subunit beta)
Sequence:
MMAECDPTDGEPGNGSGDSTPETNFLSSEVPAVLFEKTRSAPSLGLSLNPGAAVRISDSTESVLTELEADGSGEEALLLPGPAGSLSPRAGKEKRTRRNMLSSSSDNLASPGNSSGEFNHFPEDPEFGEIIQRAEQAIENGVFPERISQGSSGSYFVKDPKGKIIGVFKPKSEEPYGHLNPKWTKYFHKVCCPCCFGRGCLIPNQGYLSEAAASLVDQKLGLWIVPKTKVVHLASETFHYNAIDRAKSRGKKYALEKVPKVGRRFHRVGLPPKVGSFQLFVEGYHEADFWLRKFEAEPLPENMRKQLQSQFERLVVLDYVIRNTDRGNDNWLIKYEKPGDGELTEKESEWTDPKDSAIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVAFSQETRDLVLSRISDMNFVQDLCEDLYEMFRTDKGFDKTMFEKQMSVMRGQILNLTQALKDGKSPIQLVQMPRVVVERSRSGGQGRVVQLGNAFTQTFHCKRPFFTSW
Protein: T-related protein (Trp) (Protein brachyenteron) (P55965)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the specification of the hindgut and anal pads.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MTTSHILSAVDPTTGLSGNVSGGGGGGGAGGGAGSGSPQHVTHNGHGHGHGLGGVAAVSGGGASVSGNGGHRVVGGAGSPNELDRNLRISLDDRELWLRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEVPPSNPIYVHPESPNFGAHWMKEPISFAKVKLTNKTNGNGQIMLNSLHKYEPRVHLVRVGSEQRHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKERPDTLYPHDTHYGWLIPPPTHYTAAAAAVAAPPPLSIAQSHGLVASCPSVSSAESVGPSSGGSCDRYGRSLSSRSVAPTRTTPYSRPRVVSGSGSNGSAGNASSTSPQPPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVDASPTASVFSYPSSWQSNGNYWNATSVPGPMPMNVCSGRNISSHNSPSPTNGSPSYTTSSPSYTIHHLTPHSHQYNMAQTDIYGTGVGVGGGAGTTGSPQAAYGAAAHQVYHPTPTSPTHQLYTNAVLNAPSALSYSASGWHNGSGAEYGLYQNAAAAYYQPEYIPLEIGYATHPLEPVDVSKTLDDPQAAMYKPSDEQGSVITLECASSSLKSSHDIKIESSSLEHAGERGTVGGGAAVVSVPTAVVNGAPAVAADTWTPLTPPQSTLQ
Protein: Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) (P97536)
Organism: Rattus norvegicus (Rat)
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity). May indirectly enhance transcription from various types of promoters.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86VP6}. Nucleus {ECO:0000250|UniProtKB:Q86VP6}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q86VP6}.
Interaction partners:
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
- Cullin-4B
- Cullin-4A
- Cullin-3
- Cullin 2
- Ubiquitin-like protein NEDD8
- RING-box protein 2
- Cullin-5
- S-phase kinase-associated protein 1
Sequence:
MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNLGPDLSNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDSVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
Protein: Contactin-6 (Neural recognition molecule NB-3) (P97528)
Organism: Rattus norvegicus (Rat)
Function: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. May be involved in motor coordination.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase gamma
- Neural cell adhesion molecule L1-like protein
Sequence:
MRLLWKLVILLPLINSCAGESRFTRPIFIQEPQDVIFPLDLSRSEIILSCTASGYPSPHYRWKQNGTDIDFSMTYHYRLDGGSLAISSPRTDQDIGIYQCLATNPVGTILSRKAKLQFAYIEDFETKSRSTVSVREGQGVVLLCGPPPHFGELSYDWTFNDNPLYVQEDKRRFVSQNTGNLYIAKVEPSDVGNYTCFVTNKEAHRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPMPGKVKYSNSQATLEIPKFQQEDEGFYECVAGNLRGRNLAKGQLIFYAPPEWEQKIQNTYLSIYDSLFWECKASGNPNPSYTWLKNGERLNTEERIQTENGTLIITMLNVSDSGIYQCAAENKYQTIYANAELRVLASAPDFSKNPIKKISVVQVGGDISIECKPNAFPKASISWKRGTENLKQSKRVFFLEDGSLKICNVTRSDAGSYTCVATNQFGNGKSSGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPTMEVLFVWYFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLGHSGKYLCTVQTTLERLSAVADIIVRGPPGPPEDVKVEHISSTTSQLSWRPGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGQTYNATVIGLSPWVEYEFRVVAGNNIGIGEPSKPSELLRTKASIPNVAPVNINGGGGSRSELVITWEPIPEELQNGEGFGYIIMFRPVGSTTWMKEKVALVESSKFIYRNESIMPLSPFEVKVGVYNNEGEGSLSTVSIVYSGEDEPRLAPRGTSVQSFSASDMEVSWNAIAWNRNTGRVLGYEVLYWTDNSKESMIGKIRVSGNVTTKNITGLRANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLSNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHVLETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSVGVQILKPSTQFLTMVGFFYCFVIQPLSR
Protein: CUB and LDLa domain, isoform A (Q8IQA9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLAEALGYGYLLAYVICLLCWPGEAYPASSSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRSSPLVFKNDAVAGDVWYQCSLELVTCAECVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQLKFFYRASNAHVFSLQYFSERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPRDYGIEHILTCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLVPYTDCGGMVTGPGGAITMMNMIENATDVRLFDCIWIIKPGNNYMMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRTPDEPPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSAGGELPTAGGSATTPGSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSPEQTISNCTEHTFLKRSWLVVQQVPPGRGYRVRRLRHTFSSPEAFTSDELHLPYPDFLSYGTNLPHERSSSNFGSELSRDPSSYSVGKRARLTPEDTSGSETITQEMEQSNQTLQSHVIVESHPNHSESESEAEQQVSCFGAVAQRPKRRHRGHVRSRSFSNARGGSAGRRRLMQRSSSADLLMNYATMAVSTPQKTSEAMQRLFFI
Protein: Potassium channel subfamily K member 18 (TRESK potassium channel) (D7NVC0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSVSQKRQFTGRCSTLFWRLFPHVFLILSLVLYAVLGALVFRAIEYTNPRNESEEILSIVQKVMEIVQNHTDASEQKHLINKAKYILDDYCYEKERDHGWTFFASLFFCCTVFTTVGYGRIYPLTSKGKVACVLYAMVGIPLMLLVISDVGDLLAVLLSKAYTRLNLFFRRWIGHQSWRLQSHEKTSALPQAQADTDGTYKFNQDVVVLETTNNQQVIQTRSSIRRGSFQLRNNKEIFDRIIVRESFRIKGTLSKSCSCPELDRVPTPKDELFNDIGQEMEQLDVPLLVILLMVFAYMVICSQILKCWEKQMDHSDAFYFTFITLTTIGFGDIVPEHPKFFMVTFLFIITGMAIMSMAFKLGQSQIVCFYRRCIKSLSMGKVRIHNDLNNN