wanglab/gogpt-training-data huggingface dataset:
Protein: Protein Wnt-2b (Protein Wnt-13) (O70283)
Organism: Mus musculus (Mouse)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q93097}. Secreted {ECO:0000250|UniProtKB:Q93097}.
Interaction partners:
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-4
- Wnt inhibitory factor 1
- Frizzled-3
- Frizzled-9
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-7
- Frizzled-2
- Frizzled-1
- Frizzled-5
Sequence:
MLKLQGEDEAAQLAPRRARVPVPRPTAPDVSPSSARLGLACLLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRAMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVTATQDGANFTAARQGYRHATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT
Protein: Germacrene A synthase (EC 4.2.3.23) (PatTpsCF2) (Q49SP5)
Organism: Pogostemon cablin (Patchouli) (Mentha cablin)
Function: Sesquiterpene synthase involved in germacrene A biosynthesis. Produces also dditional sesquiterpene products, including 4,5-di-epi-aristolochene, eremophilene, alpha-selinene.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
Sequence:
MAVQISETVRPFANFSPNPSLWGDQFINHKSKTQQISRIYLEEIEGLKNEVKCMLTSTPEGKMADTVNLIDTLERLGVSYHFEKEIEEKMKHLFNLIKADNYKDHEGCDLYTDALHFRLFRQHGYPISSGIFNKWMDGNGKFKESIKSDAKGLLSLYEACCLRTHGDTLLDEALVFATASLKSMAANLASPLRKQVEHALFQHLHFGIPRVEARHFITFYEEEEHKNEMLLRFAKLDFNALQALHKEELSEISKWWKDLDLISKLPYARDRVVESYFWAVGVYYQPKYSRARIMLTKTIAMTAILDDTYDSYGTLEELDVLTKAIERWDIKEINGLPEYIKGFYKQVLKLYQQLEEELAKEGRSYAVYYAIEACKELARSYAVEAKWFKKGYLPGFEEYLINSLVTSTAGYLNIISFFGVESVTKEDFEWFSKKPRIAVATQIITRVIDDIATYEVEKEKGQSATGIDCYMKEHGVSKEKAMQRFYEMSTNAWKDINEEGLSWPSSFSRDIFVQLRNFSRMVDVTYGKNEDGYSKPEKILKPLIIALFVDQIKL
Protein: Vacuolar protein sorting-associated protein 18 homolog (hVPS18) (Q9P253)
Organism: Homo sapiens (Human)
Function: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in dendrite development of Pukinje cells (By similarity).
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:11382755}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:21802320}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:18552835}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}. Note=Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Interaction partners:
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vam6/Vps39-like protein
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 33A
- Transforming growth factor-beta receptor-associated protein 1
- Vacuolar protein sorting-associated protein 8 homolog
- Vacuolar protein sorting-associated protein 33B
- Vacuolar protein sorting-associated protein 45
- Vesicle transport through interaction with t-SNAREs homolog 1A
Sequence:
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSLVVSSNQLCMSLGKDTLLRIDLGKANEPNHVELGRKDDAKVHKMFLDHTGSHLLIALSSTEVLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGGLFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAEAQGFSGLFAAYTDHPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLEKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQRRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLASLKPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASRASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPALVNYSQGGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLALQVDVDLAKQCADLPEEDEELRKKLWLKIARHVVQEEEDVQTAMACLASCPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATASAQRIRRDLQELRGRYGTVEPQDKCATCDFPLLNRPFYLFLCGHMFHADCLLQAVRPGLPAYKQARLEELQRKLGAAPPPAKGSARAKEAEGGAATAGPSREQLKADLDELVAAECVYCGELMIRSIDRPFIDPQRYEEEQLSWL
Protein: PolyA polymerase (EC 2.7.7.19) (Q7D4M2)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MPEAVQEADLLTAAAVALNRHAALLRELGSVFAAAGHELYLVGGSVRDALLGRLSPDLDFTTDARPERVQEIVRPWADAVWDTGIEFGTVGVGKSDHRMEITTFRADSYDRVSRHPEVRFGDCLEGDLVRRDFTTNAMAVRVTATGPGEFLDPLGGLAALRAKVLDTPAAPSGSFGDDPLRMLRAARFVSQLGFAVAPRVRAAIEEMAPQLARISAERVAAELDKLLVGEDPAAGIDLMVQSGMGAVVLPEIGGMRMAIDEHHQHKDVYQHSLTVLRQAIALEDDGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMVRKRMRALKYSKQMIDDISQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGALLPRLHKLVRADCTTRNKRRAARLQASYDRLEERIAELAAQEDLDRVRPDLDGNQIMAVLDIPAGPQVGEAWRYLKELRLERGPLSTEEATTELLSWWKSRGNR
Protein: Down syndrome cell adhesion molecule 1, isoform J (Q0E9I1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVAQYYEADVNKEHVIRGNSAVIKCLIPSFVADFVEVVSWHTDEEENYFPGAEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPIGARAPTFSTDSIVFSYIRPVGQSFALLCQAQAYPVPAMRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVPPKITPFDFGDEPTNFEDSVSVTCLISSGDLPIDIEWFFNEYGISSYSGISVVKGGKRNSVLSIDSVQARHAGNYSCRAKNHAAAVNYTTSLIVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPSRDLPELSAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGNHHKDDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Cytochrome f (P56771)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Cytochrome b6
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Cytochrome b6-f complex subunit 4
- Cytochrome b6-f complex subunit 5
- Cytochrome b6-f complex subunit 8
- Photosystem II CP47 reaction center protein
- Cytochrome b-c1 complex subunit Rieske-2, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-1, mitochondrial
- Cytochrome b6-f complex subunit 6
- Cytochrome b
Sequence:
MQTRNTFSWIREEITRSISVSLIIYIITWASISSAYPIFAQQNYENPREATGRIVCANCHLANKPVDIEVPQTVLPDTVFEAVVKIPYDMQLKQVLANGKKGALNVGAVLILPEGFELAPPDRISPEMKEKIGNLSFQNYRPNKKNILVIGPVPGQKYSEITFPILAPDPATNKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATAGGIISKILRKEKGGYEITIVDASNGREVIDIIPRGLELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFLGSVVLAQIFLVLKKKQFEKVQLSEMNF
Protein: Actin-related protein 3 (Actin-like protein ARP3) (Actin-like protein 3) (P47117)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:9210376}.
Interaction partners:
- Proline-rich protein LAS17
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 1
- Actin
- Cofilin
- Profilin
Sequence:
MSYLNNPAVVMDNGTGLTKLGFAGNDSPSWVFPTAIATAAPSNTKKSSGVGAPSAVSNEASYFGNSTSATNFNGATGGLLSNNLSGKRGTEDLDFYIGNEALVASQGPSYSLSYPIRHGQVENWDHMERFWENSIFKYLRTEPEDHFFLLTEPPLNPPENREQVAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSAIKNIPIAGRDITLFIQSLLRERGEADTSLRTAEKIKQEYCYVCPDIVKEFNKFDKDPSKFAQFVVENQEKTRRKVVDIGYERFLAPEIFFNPEIASSDFLTPLPTVVDQTIQACPIDVRKGLYNNIVLSGGSTMFKDFGRRLQRDLKSIVNNRIAQSELLSGTKSTGVDVSVISHRKQRNAVWFGGSLLAQTAEFKGYCHTKKDYEEYGPEIVRNFSLFNMV
Protein: Uncharacterized protein, isoform C (Q9VW85)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform C
- Cysts, isoform C
- Uncharacterized protein, isoform C
- Uncharacterized protein, isoform B
- E3 ubiquitin-protein ligase lubel
- ubiquitinyl hydrolase 1
- Rho guanine nucleotide exchange factor 3, isoform L
- Inhibitor of nuclear factor kappa-B kinase subunit beta
Sequence:
MGGGFAAPPITLASNQRPVALDQVEIPIPATDMHEKLLEKEGKTERTNLLGRSKDKPPKDKPPKQSKFAERLRRSFRRGDHRSLEIKRQEPTPEELKAKSRATPPPPSTLRSDNNNRLPFALSHLNLPGLGLGVGVGVGGHINPALLLDSPDECTPPEYAYQHLSSVATTNSSTSLESSCELGELSGSQNSVYYWASMGGEVSTSAGAAGADGTAGTGAGTGAGAGAAVPIEGQDRRRLETQNSSRSDQQPITTNASSAPGNSSRSCSLTSDSSSIRLTRLQNFLFKSSNESSRSCQGHSNEGFTVSSHNSSSGEWEQLGAYLSSSSGVGGGHDFQGGSFPEESTPDETDGTLPVETSSSGGGGGYYQYTLTSPNNPFLPEITARTYHSTYGEDGAVEGGEPTTDDLQLDGKYGCAGSRSAQLPTPSYSRAGSQESTHSEGGGPPGPTPSPASSSSSTPGRHRRKLFSLNSPTRLLHHQQQQPPPSGATSASPPSGGSSNDGGGGKFNSASLVRSLNPFLPSVTSPKKAPHKQSAVTSPGCLTPDLSTKREEFLRATMKICLVVSPPNSKLQLKSKSLTHLDGLDSGVVACQQGPPGMATSTASTTATTAGGTGATTGLFATTGAPGSLGRQANVTEKGERTGVCLSPSAPQPSSHASPHHPPTIYTQAPQVVRRMPSLMLSPTLDETTTTASSSCFGTGHPSAGSFHQHQHHHHHHQPTGSVSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSSSTLSPHSATSATLGGGGGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVESLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCTEAKNWYDALWRAKTIYQRLKRGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNHLGQSLPNLNMHHSHTNNTLLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPLRRGMAFSTSTKNPPLRKTRNITSQNSINWHQIPATPTPPSPRSQYQSPGVVCMQKSLPLLLPTNTDEGQGPTQPPPPLQKQLSHQAPLPTTIHNQSSTETDV
Protein: Serine/threonine-protein phosphatase alpha-1 isoform (EC 3.1.3.16) (P48461)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH07711p
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- LD24014p
- FI19335p1
- WD repeat-containing protein 82
- Protein phosphatase 1 regulatory subunit
- Nuclear inhibitor of protein phosphatase 1
- Cleavage and polyadenylation specificity factor 73
- Cleavage and polyadenylation specificity factor subunit 1
- Probable cleavage and polyadenylation specificity factor subunit 2
Sequence:
MSDIMNIDSIISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKRRFVYPNFGSSGRPLTPPRGANNKNKKK
Protein: Advillin (Actin-binding protein DOC6) (p92) (O88398)
Organism: Mus musculus (Mouse)
Function: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O75366}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O75366}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O75366}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9WU06}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WU06}. Note=In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. {ECO:0000250|UniProtKB:O75366}.
Interaction partners:
Sequence:
MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYIVLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITRGQFTALPGWKQLQLKKERGLF
Protein: p44-19 outer membrane protein, silent (Q2GIU3)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MLVAMEGSVGYGIGGARVELEIGYERFKTKGIRDSGSKEDDADTVYLLAKELAYDVVTGQTDNLAAALAKTSGKDIVQFAKAVEISSPTIDGKICKINTGSNKYGTGTNSGELTCGVGHASGSLGAANGAFKDFRQHVLEVESHKHWPTTQGSSDKGSNNATKVAGELTKLTTEEKTIVAGLLAKTIEGGEVVEIRAVSSTSVMVNACYDLLSEGLGVVPYACVGLGGNFVGVVDGHITPKLAYRLKAGLSYQLSPEISAFAGGFYHRVVGDGVYDDLPAQRLVDDTSPAGRTKDTAIANFSMAYVGGEFGVRFAF
Protein: N-acetylaspartylglutamate synthase A (NAAG synthetase A) (NAAGS) (EC 6.3.2.41) (N-acetylaspartylglutamylglutamate synthase A) (EC 6.3.2.42) (Ribosomal protein S6 modification-like protein A) (Q6PFX8)
Organism: Mus musculus (Mouse)
Function: Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- N-acetylaspartate synthetase
- Glutamate carboxypeptidase 2
- Beta-citrylglutamate synthase B
- Aspartoacylase
Sequence:
MCAQVWLLTDRLIREDYPQVQILRALRQRCSEQDVGFRAVFLDQIAVTVVGGHLGLQLSQKPLTTFPDVVVVRVSTPSVQSDSEITILRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDICHLVRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCFLGGVGVKCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFTVCEANANVGFLAFDQACNLDVGAIIADYAMSLLPNRQTGKMAILPGLASPREKNEPNGCVSAQGVAESVYAITNGSTSSESEPELGEARDSSVKTMGAPPAHVAQAWLQH
Protein: N-myc proto-oncogene protein (P03966)
Organism: Mus musculus (Mouse)
Function: Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Subcellular location: Nucleus.
Interaction partners:
- Protein max
- Aurora kinase A
- Histone-lysine N-methyltransferase EZH2
- Zinc finger X-chromosomal protein
- Bromodomain-containing protein 4
- N-myc-interactor
- Transcription factor E2F1
- RAC-alpha serine/threonine-protein kinase
- Cellular tumor antigen p53
- Zinc finger protein GLI1
Sequence:
MPSCTASTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRAFPEHSPEPSNWATEMLLPEADLWGNPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVNEKLQHGHGPPGVSSACSAPGVGASSPGGRALGGSSSASHTGATLPTDLSHPAAECVDPAVVFPFPVNKRESASVPAAPTSAPATSAAVTSVSVPATAPVAAPARAGGRPASSGEAKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNNKAVTTFTITVRPKTSALGLGRAQPGELILKRCVPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVVPAKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHALQANEHQLLLEKEKLQARQQQLLKKIEHARTC
Protein: Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) (Q7Z6I6)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:21565175}.
Interaction partners:
- Rho-related GTP-binding protein RhoU
- SAM and SH3 domain-containing protein 3
Sequence:
MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
Protein: Protein TMEPAI (NEDD4 WW domain-binding protein 4) (Prostate transmembrane protein androgen induced 1) (Transmembrane prostate androgen-induced protein) (Q9D7R2)
Organism: Mus musculus (Mouse)
Function: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
Subcellular location: Early endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mothers against decapentaplegic homolog 2
- E3 ubiquitin-protein ligase NEDD4
- Mothers against decapentaplegic homolog 3
Sequence:
MSPARATAQRSLFPSMEITELEFVQIVVIVVVMMVMVVMITCLLSHYKLSARSFISRHSQARRRDDGLSSEGCLWPSESTVSGGMPEPQVYAPPRPTDRLAVPPFIQRSRFQPTYPYLQHEIALPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLIDSTMLGGPCPPSSNSGISATCYSSGGRMEGPPPTYSEVIGHYPGSSFQHQQSNGPSSLLEGTRLHHSHIAPLENKEKEKQKGHPL
Protein: Proline-rich protein 30 (Q53SZ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLPQNKDQVLPQTSVLPGRPTWGFSQLVDSSPHNLQPLSPHQGLPPSQPPFSSTQSRRPSSPPPASPSPGFQFGSCDSNSDFAPHPYSPSLPSSPTFFHQNYLSLPRPRASSPSNHWLYPSPPLTPSFSPSQPQNSSLPHSPCQSPSHPEELHSSTLTSPGPSPPSHRLHSNRQTWRWHQYRDTGSGSPGVVERCVPSEKDPAQFRDPGALAQALVVQLGHRRIAHDLRLLLLQHLWLGRTGQAPVVEYPICLVCLRPRSPSCPLPRYRTGPRLLAFPQLLPCVQGQESGPLRIGIGFGLRLPQGQARALHLLPEKRPKEAGPQGKATQACGHQLPASQPPAAQARADPVPGTPSQTRSFRSAGLQSPNSPRCFSGPPPRAPKQVTTSLKPRPCPGPKRPVSLELILQKSSV
Protein: Kinesin family member 5A, a (Kinesin family member 5Aa) (A0A0R4IWI7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin light chain
- Kinesin light chain
- Spastin
- Trafficking kinesin-binding protein 1 isoform X4
- Kinesin light chain 4
- Kinesin-like protein
Sequence:
MTDAAAECNIKVLCRFRPLNQAEILRGDKFLPTFQGDDTVIIGGKSYAFDRVFPTNTTQEQVYNTCAKQIVKDVLGGYNGTIFAYGQTSSGKTHTMEGNLHDPQQMGIIPRIAEDIFNHIFSMDENLEFHIKVSYFEIYMEKIRDLLDVTKTNLSVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQEHVETEQKLCGKLYLVDLAGSEKVSKTGAAGAVLDEAKNINKSLSALGNVISALAEGTKSHVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASINLELTAEQWKRKYEKEKEKNKSLRDSMQRLELELRRWRNGEKVPETEQTDADVVKLDVSEETSLDNEKSCERQRERERDSDTSSIVVRISEEERQKYEEEIRKLYRQLDDKDDEINLQCQLVEKLKEQILDQDELLASTRGDSDKVQTELGRLQTESESAKAEVREVLQALEELAVNYDQKSQEVEEKSLHNKQLAEQLSHKMANLMELEAELAQMQEVSSQQRKRIADVLNGLMKDLSEFSSIVGNGELKLPVEISGAIEEEFTVARLYISKIKSEVKSMVKRCRQLENMQLECHRKMEETSRELSSCQLLISQHEAKIRSLTEYMQNVEQKKRQLEDNYDALSEELYTLQNSESHVAELDGGEKADREADGKKAAVRPALHAESRQTQLSRLRDEINEKQRLIDELTDKNQALELELAHVRSSFSNLKLQDDSKSACLEQMSFQQERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDLTTRVKKSSEIGPDDSGGSNTQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRSTAERVRALETALKDAKQGAMNDRRRYQQEVERIRDAMRLRYPLRRPNAAQIAKPVRPGHHVTATSPTSFSVTRASKPATSYSNARFLQDEKMENSQKTNTVGYSTVRSIDILSSCPLDVENGNSTDINDNRSDVHCGSMVDDASRVYIMQQETAAS
Protein: ORM1-like protein (dORMDL) (Q9VP04)
Organism: Drosophila melanogaster (Fruit fly)
Function: Negative regulator of sphingolipid synthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Serine palmitoyltransferase 1
- serine C-palmitoyltransferase
- Serine palmitoyltransferase small subunit B
Sequence:
MTSIAGGHGEANPNSSWLSARGFWLAYLLGLLSVHLLFLSVPFVSIPWAWTATNLLHNAAHLYFLHVIKGAPWLSTENDPSRRWTHWEQIDDGVQMTTTRKFLTAVPIVLFLLTCLYTRNNTEHFIPNFISLVVVTLPKLPQFHGVRLFNINKY