wanglab/gogpt-training-data huggingface dataset:
Protein: G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor) (Q9HC97)
Organism: Homo sapiens (Human)
Function: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16754668, ECO:0000269|PubMed:20361937, ECO:0000269|PubMed:35101446}; Multi-pass membrane protein {ECO:0000269|PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
Interaction partners:
- C-X-C motif chemokine 17
- Calpain-10
Sequence:
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
Protein: Ras-related protein ralB-A (EC 3.6.5.2) (XRalB-A) (Q9YH09)
Organism: Xenopus laevis (African clawed frog)
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Regulates the actin cytoskeleton to play a role in gastrulation or neurulation. During the cleavage stages, the GTP-bound form induces a cortical reaction that affects the localization of pigment granules. Activated by the FGF pathway via ras and ral-GDS, but independently of raf. Directs ralbp1 to the plasma membrane. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11234}; Lipid-anchor {ECO:0000250|UniProtKB:P11234}; Cytoplasmic side {ECO:0000250|UniProtKB:P11234}. Midbody {ECO:0000250|UniProtKB:P11234}. Note=During late cytokinesis, enriched at the midbody. {ECO:0000250|UniProtKB:P11234}.
Interaction partners:
Sequence:
MAANKNKNQSSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLIVGNKSDLEDRRQVPMDEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSGKSKKGFKQRCCLL
Protein: Rieske (2Fe-2S) domain-containing protein (Q9C9I7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Monodehydroascorbate reductase 4, peroxisomal
- Monodehydroascorbate reductase 1, peroxisomal
- Monodehydroascorbate reductase 3
- Monodehydroascorbate reductase 2
- Monodehydroascorbate reductase, chloroplastic/mitochondrial
- Protochlorophyllide-dependent translocon component 52, chloroplastic
- S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplastic
- PsbP-like protein 1, chloroplastic
- Photosystem II stability/assembly factor HCF136
- Protein disulfide-isomerase LQY1, chloroplastic
Sequence:
MATTASSSLPRNYSFTTPRPSSFIRGPPLARTLPLYLRRNRRVALTYRLDQNSKQRSGGNVRCEATEVSSSSSVSTPGRNWVPVVPLSALPKGERRVVIQDDETILLLWYKNDVFAIENRSPAEGAYSEGLLNARLTQDGCIVCPSTDSTFDLRTGEIREWYPKNPVLRVLTPALRKLFVYPVKYDEENIYISIRDSGKTEAAAEIVFSGKAQPGLTATNVNVDEVRMIVDEGSEGFGFTKKNEVINGKAAVIGFLLLLDFELLTGKGLLKGTGFLDFLYSASDAFK
Protein: Uncharacterized protein orf241 (Q2F966)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MHILSCSCLNVVQMVVIIVYVFLYGRLYLALSGLEFAIMKQARMRGNRALQAAMGSQSIVQLGLLMALPMFMGIGLERGFRSALGDFIIMQLQLCSVFFTFYLGTKSHYFGRTILHGGAKYRATGRGFVVRHVRFAENYRMYSRSHFVKGLELMLLLVVYQLYGDVATDSTAYILLTSSMWFLVITWLFAPFLFNPSGFEWQKIVDDWTKWISSRGGIGVPANKAWESRWEEEQQAAPLPL
Protein: Probable trehalose-phosphate phosphatase D (AtTPPD) (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (Q67XC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance (By similarity).
Interaction partners:
- Trehalase
- Alpha,alpha-trehalose-phosphate synthase 1
- Probable alpha,alpha-trehalose-phosphate synthase 2
- Probable alpha,alpha-trehalose-phosphate synthase 10
- Alpha,alpha-trehalose-phosphate synthase 5
- Probable alpha,alpha-trehalose-phosphate synthase 4
- Probable alpha,alpha-trehalose-phosphate synthase 3
- Probable alpha,alpha-trehalose-phosphate synthase 11
- Alpha,alpha-trehalose-phosphate synthase 6
- Sucrose synthase 6
Sequence:
MTNHNALISDAKGSIGVAVRVPNQSLFSPGGGRYISIPRKKLVQKLEADPSQTRIHTWIEAMRASSPTRTRPGNISPLPESDEEDEYSSWMAQHPSALTMFEEIAEASKGKQIVMFLDYDGTLSPIVENPDRAYMSEEMREAVKGVARYFPTAIVTGRCRDKVRRFVKLPGLYYAGSHGMDIKGPSKRNKHNKNNKGVLFQAANEFLPMIDKVSKCLVEKMRDIEGANVENNKFCVSVHYRCVDQKDWGLVAEHVTSILSEYPKLRLTQGRKVLEIRPTIKWDKGKALEFLLESLGFANSNDVLPIYIGDDRTDEDAFKVLRNKGQGFGILVSKIPKETSATYSLQEPSEVGEFLQRLVEWKQMSLRGR
Protein: Transcription factor (Q24156)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
Interaction partners:
Sequence:
MSAASEVNLMLLRSVEKQTALYDRTDENYRKRLPSENAWDMVASEVGESVEKCKRRWRQLRNDYTRWCNADANRRRNGQRRLAYPLADELRFLDRHLNIADDMAADDDRSVSSDKDRDNNRDSEGVDHHAQASLKERASSTSKLVKEVKLASQVRKEKSSQDKRENWENPGDKQRSRKKSAEEKLDDLEESDEPEKVPELDSFLQSDNEDDECMDEEHLDDLEGFDFDLEQSNQEKELTPEKSLEKNNTDSTVSQPEFFVKQTRDPRLLIIGRKNSTSSFAESKASKSISGDPLETAMEDSGDEYGRDGEKRVTGSDTTSPTRRPRRAARASISFAGIRDLPIQKPGQAQRMTRLQRRKSMSLAAVHSVRSSTSPVKMTPVPRSQPINKPPSGPVQITKISHRDDIFPRPAVPSGVVNINQNQLKTQQQQKTLIFPTTDEAIANPHGSGPPQRRSVGRPPKKLPMVQRIVAPETQTKPQSPINTKVLTIGKPTSSVASGNINNIAIKSNVVTSISSSTATTNTITKGTSNNSIKTTENVNVISYSKNSSSTSSSSKATTGASGAVITNIPTTTTAGTSVPVGKSITQLKMTERGTQTGVQNPFSDNYFLEMIKPQMQEMNPRQKMHFKKKVFQALMETFDDATDFPTSKELQHFNINTPSGFEHITDPELRLVRELVSMVSAAKVTLIRPPGEATAIATASRSGIAPEVQRGPRTNMTRQVIQRVYKPGTGQEIAPTSPAGGLDKRLFRLAAMGGKPNGNLSATQEILRKDSVDSNHSVVKVANHAPTGSPKGAAVVAAIRPQGSLINSFFGQGNGPTTAKGAASENIRAMSRRYSVCGSSNPPNAQNASQGSANGSTINSNASAMEASMLKRRLIAAGHGMVPPTQRPRYSAVGASQMTTASQGSSLLVRKSVGCVPAYQKQISPNGGASLLQKTPQIASVQGSAFNDFAQPKPAATASVNGEESSPTSALKRSLVVANTKTSFQDLLQQASQTVQRNKIESSETAATIAADDFSLDNLKREPVDPAEDHNDILGV
Protein: B-related factor 1 (Q9VEL2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- TATA-box-binding protein
- B double prime 1, isoform A
- TBP-related factor
- LD44919p
- DNA-directed RNA polymerase subunit
- FI04119p
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC3
Sequence:
MSTGLKCRNCGSNEIEEDNARGDRVCMNCGSVLEDSLIVSEVQFEEVGHGAAAIGQFVSAESSGGATNYGYGKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQHYADTALNFFKMALGRHLTRGRKSTHIYAACVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCINIPSLDPCLYIMRFANRLQLGAKTHEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFSRTMLDVIGVVKIHESTLRKRLSEFAETPSGGLTLEEFMTVDLEREQDPPSFKAARKKDRERIKDMGEHELTELQKEIDAHLEKDLGKYSNSVYRQLTKGKGLSPLSSPSTPNSSSEKDIELEESRQFIEQSNAEVIKELIAKNEDVKKSEPGGLVAGIEGLRPDIEAICRVTQSDLEDVEKAKQPQEQELITDDLNDDELDQYVLTEEESVAKLEMWKNLNAEYLQEQKERDERLAKEREEGKPERKKRKPRKKVIGPSSTAGEAIEKMLQEKKISSKINYEILKTLTDGMGGLTDDSPTTSADTKPSTLEELKHQPVIVEEGPVASKSRGNRAAYDLPGPSRKRPKLEVGLPVSKAADVEQAETKPAVVVEADDLDEDADDPDVEPEAEPEATLQDMLNTGGDDDEFGYGFDEEEEY
Protein: MHC class I alpha (U3PTD3)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGPCGALGLGLLLVAVCGAAAEHHTLRYVHTAMTDPGPGQPWYVDVGYVDGELFVHYNSTARRYVPRTEWMAAKADQQYWDGQTQIGQRNERSVKVSLDTLQERYNQTGGSHTVQWMSGCDILEDGTIRGYYQSAYDGRDFIAFDKGAKTFTAAVPEAVPTKRKWEEGGVAERWKSYLEETCVEWLRRYVEYGKAELGRRERPEVRVWGKEADGILTLSCRAHGFYPRPIAVSWLKDGAVRDQDAQSGGIVPNGDGTYHTWVTIDAQPGDGDKYQCRVEHASLPQPGLYSWEPPQPNLVPIVAGVAVAIVAIAIVVGVGFIIYRRHAGKKGKGYNIAPGSNPSI
Protein: Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1) (Q9WVK8)
Organism: Mus musculus (Mouse)
Function: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation. By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning. Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (By similarity). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (By similarity). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18241055}; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Postsynapse {ECO:0000269|PubMed:16505352}. Presynapse {ECO:0000269|PubMed:16505352}. Cell projection, dendrite {ECO:0000269|PubMed:18241055}.
Interaction partners:
- 24-hydroxycholesterol 7-alpha-hydroxylase
- Cytochrome P450 7A1
- Cholesterol 25-hydroxylase
- Sterol 26-hydroxylase, mitochondrial
- NADPH--cytochrome P450 reductase
- 7-dehydrocholesterol reductase
- Delta
- Sterol O-acyltransferase 1
- Sterol O-acyltransferase 2
- Bile salt-activated lipase
Sequence:
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
Protein: UTP4 small subunit processome component (H3BPD7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRI
Protein: Taste receptor type 2 member 107 (T2R107) (Taste receptor type 2 member 4) (T2R4) (Q9JKT9)
Organism: Rattus norvegicus (Rat)
Function: Putative taste receptor which may play a role in the perception of bitterness.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 2 member 16
Sequence:
MLSAAEGILLCVVTSEAVLGVLGDTFIALANCMEYAKNKKLSKIGFILIGLAISRIGVVWIIILQGYMQVFFPHILTFGNITEYITYIWVFLNHLSVWFATNLNILYFLKIANFSNSVFLWLKSRVRVVFIFLSGCLLTSWLLCFPQFSKMLNNSKMYWGNTSWLQQQKNVFLINQSLTNLGIFFFIIVSLITCFLLIVFLWRHIRQMHSDGSGLRDLNTEAHVKAMRVLISFAVLFILHFVGLSIQVLCFFLPQNNLLFITGLIATCLYPCGHSIILILGNKQLKQASLKALQHLTCCETKRNLSVT
Protein: Dynein axonemal assembly factor 3 homolog (A1ZB91)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the assembly of axonemal inner and outer dynein arms. Involved in the cytoplasmic preassembly of dyneins into complexes before their transport into cilia. Essential for the development of axonemal dynein motors in the sensory cilium of mechanosensory chordotonal (Ch) neurons and sperm flagellum, and consequently, is required for the mechanotransduction process of hearing and sperm mobility.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34553759}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q32NQ7}. Note=Detected in the cytoplasm of differentiating motile ciliated cells including the chordotonal (Ch) neurons, spermatocytes and spermatids. {ECO:0000269|PubMed:34553759}.
Interaction partners:
- Zinc finger MYND domain-containing protein 10 homolog
- IP16893p
- Troponin T, skeletal muscle
- Putative inner dynein arm light chain, axonemal
- Dynein axonemal assembly factor 5
- Protein tilB
- Spag1 axonemal dynein assembly factor
- IP21091p
Sequence:
MLWGISSALDLYEEYLRAFKIKDDPLPEDEHAREEAEEAAGDNTLNTLNILICGGADPRHVIKTLAKRYTHRIRPKLNIYLLDGCAEIEARNMLLLGVALEDPESFNLVSKVHLFMDLYGNAVIRPSSHHYMAAKGRTLLKMVTNEEELQRLAPMLNIEGLKYKERDGFEMAFTFWQPQPWNVFEVTAYWEQRSRALLGTRYDHRNGAFDWDLSMTLKERGGQQICSQEYRYWRETGVAFVFPEYEHCKPNKTLAVGLVRNGRNFIHRGYVGDIQTGPFCGFGLRTVEERMHHSVHGDNDYRATDITERNLMEFFHELLTQTAYEHDTTRSRRYGSVQLLMTPLLNHQEEDAAGQAAYDKPWIHVPGVTVHFVSPMEMEQLKKGAAHWNNMFDIVFMAYNYYSFLSKDFFQAMRAQSLFILETKLMTVERKDRVQEYESKAKELMKDAGLKAAINYQAINGKNMWLKYKKTDKDEQEDEAVTEAMPESTFKYDTDTDYGEPAEEYTGLVIEEIPSSNQTVAAIKKEVEAEGPLQPKTNFP
Protein: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) (H0YLI6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAF
Protein: Transcription elongation factor SPT4 homolog 2 (Q94C60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate transcription elongation by RNA polymerase II. May enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases II, IV and V subunit 11
- FACT complex subunit SSRP1
- DNA-directed RNA polymerase II subunit 4
- Putative transcription elongation factor SPT5 homolog 2
- Protein RNA-directed DNA methylation 3
- Putative transcription elongation factor SPT5 homolog 1
- Transcription elongation factor SPT6 homolog
- FACT complex subunit
- FACT complex subunit SPT16
- DNA-directed RNA polymerase subunit 10-like protein
Sequence:
MGSAPAQIPTSFGHELRACLRCRLVKTYDQFRDAGCENCPFFKMEEDHERIVEVTTPNFNGIISVMDPSRSWAARWLRIGKFAPGCYTLAVSEPLPEEMQHLCQEERVQYVLPKRM
Protein: Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (DmCdk8) (Mediator complex subunit Cdk8) (Mediator of RNA polymerase II transcription subunit Cdk8) (Q9VT57)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:8730095}.
Interaction partners:
- Cyclin-C
- Mediator of RNA polymerase II transcription subunit 13
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 18
Sequence:
MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQMNAEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQQQQMMFNQQQNFQRFN
Protein: Steroid hormone receptor ERR1 (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) (Q5QJV7)
Organism: Rattus norvegicus (Rat)
Function: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P11474, ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:P11474}. Note=Co-localizes to the cytoplasm only in presence of MAPK15. {ECO:0000250|UniProtKB:P11474}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta
- Peroxisome proliferator-activated receptor gamma
- Nuclear receptor interacting protein 1
- Transcription factor A, mitochondrial
- High affinity cationic amino acid transporter 1
- Nuclear respiratory factor 1
- NAD-dependent protein deacetylase sirtuin-1
- Nuclear receptor corepressor 1
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
Protein: Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase) (Q9HAT2)
Organism: Homo sapiens (Human)
Function: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
Subcellular location: [Isoform 1]: Lysosome {ECO:0000269|PubMed:15292578, ECO:0000269|PubMed:21803834}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21803834}.
Interaction partners:
- N-acetylneuraminate
- B-cell receptor CD22
Sequence:
MVAPGLVLGLVLPLILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSLTLAIDSCHGTVVALRYAWTTWPCEYKQCPLYHPSSALPAPPFIAFITDQGPGHQSNVAK
Protein: SRRM2 protein homolog rsr-2 (SR protein-related rsr-2) (Q9U213)
Organism: Caenorhabditis elegans
Function: Plays a role in pre-mRNA splicing as component of the spliceosome (By similarity). Involved in modulating global transcription, probably acting via interaction with RNA polymerase II. Influences the chromatin distribution and phosphorylation state of RNA polymerase II subunit ama-1. Involved in regulating the germline sex determination pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:23754964}. Chromosome {ECO:0000269|PubMed:23754964}. Nucleus, nuclear body {ECO:0000269|PubMed:23754964}. Note=Localized to nuclear chromatin (at protein level) (PubMed:23754964). Localization along chromatin is similar to that for RNA polymerase II subunit ama-1 (PubMed:23754964). {ECO:0000269|PubMed:23754964}.
Interaction partners:
- Pre-mRNA-splicing factor 8 homolog
- Tr-type G domain-containing protein
- Cell division cycle 5-like protein
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Protein BUD31 homolog
- Pre-mRNA-processing factor 19
- Probable U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor CWC22 homolog
- Pre-mRNA-splicing factor syf-2
- Probable small nuclear ribonucleoprotein-associated protein B
Sequence:
MYNGIGLQTARGSGTNGYVQSNLSHLMQARRKIEYNGEDDLRKMEAELNRKPNEEIMDHNRKRQIEVKCTEFEMLLEDKGLDDEDIERKVGEYRKNLLKQLESGELNVDEELSTKESHARRRAAANNRDKMRNALGLGEDYVPGSSMAKMNKSDVVGAAMESELPQKDDKEKLLETLRLHRKSKKKQESSSSSSSSSSSSESSSEDEKHRKDRKKKEKKQKLKEMEKRREKLRQKERELLAVSDKVKKEEPAESSDEEDSRKDQRKPREDRRRSVERQDQREDRRDRRRSPEDPRERRRSPEDRTVRRRSPERRRQQRSPSVERRKSPQRRDERRRRHDSSENERRSTATASKKSRMDELEVKQEPPSDSEDYIAKTNLAPIRVEKSAEKVEKSRKSSSESSSGSSDSDSSSDSSSSSDSSSDSE
Protein: Peroxisomal adenine nucleotide transporter 1 (Q06497)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:11390660, ECO:0000269|PubMed:11566870, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:11390660, ECO:0000269|PubMed:11566870, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Peroxisomal membrane protein import receptor PEX19
- Uncharacterized protein YGR168C
Sequence:
MLTLESALTGAVASAMANIAVYPLDLSKTIIQSQVSPSSSEDSNEGKVLPNRRYKNVVDCMINIFKEKGILGLYQGMTVTTVATFVQNFVYFFWYTFIRKSYMKHKLLGLQSLKNRDGPITPSTIEELVLGVAAASISQLFTSPMAVVATRQQTVHSAESAKFTNVIKDIYRENNGDITAFWKGLRTGLALTINPSITYASFQRLKEVFFHDHSNDAGSLSAVQNFILGVLSKMISTLVTQPLIVAKAMLQSAGSKFTTFQEALLYLYKNEGLKSLWKGVLPQLTKGVIVQGLLFAFRGELTKSLKRLIFLYSSFFLKHNGQRKLAST
Protein: Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V) (Q9R0N9)
Organism: Mus musculus (Mouse)
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
Interaction partners:
Sequence:
MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPRLRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLFSGSKDNNQEPLNYTDTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQPGGQENCAHAVRVQRQVTEPTPSARHNSIRRQLNLSNPDFNIQQLQRQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVHYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFFDLADFPRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQIHLSIAVMDYDRVGHNEVIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLMEKR