wanglab/gogpt-training-data huggingface dataset:
Protein: Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] (O89051)
Organism: Mus musculus (Mouse)
Function: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).
Subcellular location: [Integral membrane protein 2B]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y287}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y287}. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted. {ECO:0000250|UniProtKB:Q9Y287}.; SUBCELLULAR LOCATION: [BRI2, membrane form]: Cell membrane {ECO:0000250|UniProtKB:Q9Y287}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y287}. Endosome membrane {ECO:0000250|UniProtKB:Q9Y287}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y287}. Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. {ECO:0000250|UniProtKB:Q9Y287}.; SUBCELLULAR LOCATION: [Bri23 peptide]: Secreted {ECO:0000250|UniProtKB:Q9Y287}. Note=Detected in the cerebral spinal fluid (CSF). {ECO:0000250|UniProtKB:Q9Y287}.; SUBCELLULAR LOCATION: [BRI2C, soluble form]: Secreted {ECO:0000250|UniProtKB:Q9Y287}.
Interaction partners:
- Amyloid-beta precursor protein
Sequence:
MVKVTFNSALAQKEAKKDEPKSSEEALIVPPDAVAVDCKDPGDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGLKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDNLGFFIYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS
Protein: Failed axon connections (Q95RI5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Together with Abl, involved in embryonic axonal development.
Interaction partners:
Sequence:
MASEVAQIPAEETPAVAAAEKSEEPEKSAAPPADSAAAPAAAPAVEKAEDADGEKKDGEAGKQDKQQDGEEPKKDEAVAAPVATKSEAPPAQKFNVHKTNFEKDIIYLYQFSRTPLLPSLSPYCLKVETWLRLVGLKYENVDHKMRFRSKKGQLPFIELNGEEIADSAIIIKELSSKYEKYLDSGLTAEQRNVSYATIAMLENHLIWIIFYWRAKYPDNVLKGYKVNLQHALGLRLPNSILNFFFKITFGRKWFQGTKKLKAHGIGVHSAEEIEEFGKDDLKVLSEMLDCKPFFFGDEPTTLDVVAFAVLSQLHYLSKDIAYPLRDYMTEKCPNLIGHVSRMKDKCFPDWDEICTKLDLNAHIPKPEPETKEGKEGGEQEKSNEQEGTEGDKIEKELEKDKSNEKESTEENKEKEETK
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (D6XMU9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361146}.
Interaction partners:
Sequence:
MHPLESPQEHKTQVSPENNGNETKSVLQKLFTCNEDPKPLYEELGGVEGIAERLGTSITDGIDSFSVENRRAVYGRNELPEEAPLTFWKILKAAWSDRMIILLTLAACVSLILGLTVPEPGHEKVDYKTGWIEGTAILMAVIAVTSASSIQDYRKELKFRALVEENSAQPISVIRDGHKVTVDVTEIVVGDLVSLSPGLVIPVDGLYVRGLSVVVDESSVTGENDLKKKGAEHPILLSGTVVSTAEDAYILACAVGESSFGGKLLMESRLDGEPRATPLQERLDELAAFIGRVAIISAVLLFIVLCIIEIERIATNKQQFYPKKFLNFLLLCVTIVVVAVPEGLPLAVTIALAYSQNQMQKDNNQVRRLCACETMGNATQICSDKTGTLTQNRMTVVQGYIGMRRFRVSNPGDPSSTVNLEGVSSDAQSLLMLGLALNSSSEKELLPGNVGAESDLLSRWTWRTDKGNKTDQAILDFVDRVLISVPGSCNDKELPHQKLRMTNRSRGFAIFPFTSERKFMTAVVAGADGVVMQYVKGGSDRVLGMCNRYLSSEGREEPLTEEVTEMITEQIRSIAGDANRTIGVAYGRIGTDGAVPEEEPEGPFVWLALLGIQDPLRPEVVDAVRMCQRAGVTVRMCTGDNLDTAVAISRQCGIYNRLRGDLALTGKDFRNLVYDTYGDEANMEKFWPVLDRMMVMGRSQPLDKQLLVLMLMLRGEVVAVTGDGTNDAPALRLANVGFVMRSGTDIAVKSGDIVLLDDNFRSVQRAVVWGRTVNDNIRKFLQLQLTVNVVSFLVTVVGTLVREGKSSPLTTVQLLWVNLLMDTLAALALATEQPTEDCLNRGPSSPRAPLVSRRMWFTIFSVATVQLTAFFSVLTFGGKYFGEDENGKHLHRTFLFNVFVFGTIFHMLNCRKLYRELNVFEGMGRSVFFIVVVGSCIAFQVLAICTFNDFMGVRPLSIKQWGVSIGIAAISLVVGILSRVVSIREPVFALIPDSRNVDGSASRLIKDVSVAAEQRQRETDGTSDASSLLAGRLRAQSRWRRLQAEHVKKPRVVNAFRRAWTDRDMKRGSTRQLYDTLRMV
Protein: Non-histone chromosomal protein 6 (Q9UVL1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000250}.
Interaction partners:
- FACT complex subunit POB3
- Histone H2A.Z
- Histone H2A.2
- Histone H3.1/H3.2
- TFIIH/NER complex subunit
- Arp8p
- FACT complex subunit SPT16
- General transcription and DNA repair factor IIH subunit TFB4
- Gcf1p
Sequence:
MAPGERKKSSRKKKDPDAPKRSLSAYMFFANENRDIVRAENPGISFGQVGKLLGEKWKALNSEDKLPYENKAEADKKRYEKEKAEYAKKNSA
Protein: Aryl hydrocarbon receptor repressor (E5L8C8)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein.
- Aryl hydrocarbon receptor nuclear translocator 2.
- Ubiquitin-like protein 5
- TCDD inducible poly
- Basic helix-loop-helix ARNT-like protein 1
- Basic helix-loop-helix ARNT-like protein 2
Sequence:
MIPPGECLYAGRKRRKPIQKQRPAAGNEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQAIQEKHFKKQVGQTIKEDNVSNKTAVQEGGLLLESLNGFALVVSADGMIFYASSTIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMNPPQMSGQQLQTETGEEYILSKLFKAQENDSTTTDYSSFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQRKKSSSGAVLPPQLSLFCIVVPLLLPSVTEMKMKSLLVKAKHKADDAAVNTNSSTKSNSGLCEAAELYGRNCHHEGAAFANVLQITENQFKAKNNGENGISLVKVQTNEDHWVWVQANTQLLYRSGCSEYVVAQQQMLKEEDEQLKIPNSFASLKGNLEGLSYNGAIETLGQLKHLNWTAVKNEQDNVKVKFEPHTNGECFVQEESLTSNTPVLGIQNNCTTNNSWTFRNSSSCSINQRMNACSNRRAGSFYNRDQSFLNLASTCPSHWGSAENCQSYSGLQQRAVENYTADHLKLQRSLISSESLYDAAFPLDMPIKTEYDSDSENIADNYPMPQNRAWLDENGTMRKQLFSYPNRVHLKAEPDLCQQASPCQKPRHCLYTPHNWQCIVANHPSNLNLNRSCKGLRNREVAPFCPQNSSACLESLPDQPHTEGYGQFYSLAPGEKEQSNEVFKMPCEFKNPCLVQAIKREPLDSPPLSNSGQNRAHMSFPENTIAGPVPHKATECTFLQ
Protein: Chalcone synthase (EC 2.3.1.74) (Naringenin-chalcone synthase) (Protein TRANSPARENT TESTA 4) (P13114)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Interaction partners:
- Chalcone--flavanone isomerase 1
- Trans-cinnamate 4-monooxygenase
- Flavonol synthase/flavanone 3-hydroxylase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Dihydroflavonol 4-reductase
- Probable chalcone--flavanone isomerase 3
- 4-coumarate--CoA ligase 3
- Shikimate O-hydroxycinnamoyltransferase
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Probable caffeoyl-CoA O-methyltransferase At4g26220
Sequence:
MVMAGASSLDEIRQAQRADGPAGILAIGTANPENHVLQAEYPDYYFRITNSEHMTDLKEKFKRMCDKSTIRKRHMHLTEEFLKENPHMCAYMAPSLDTRQDIVVVEVPKLGKEAAVKAIKEWGQPKSKITHVVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRIAKDLAENNRGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFSDGAAALIVGSDPDTSVGEKPIFEMVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIVKSLDEAFKPLGISDWNSLFWIAHPGGPAILDQVEIKLGLKEEKMRATRHVLSEYGNMSSACVLFILDEMRRKSAKDGVATTGEGLEWGVLFGFGPGLTVETVVLHSVPL
Protein: Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) (P21453)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29185452}; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Interaction partners:
- Early activation antigen CD69
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Sphingosine 1-phosphate receptor 4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Sphingosine kinase 1
- Sphingosine kinase 2
- Krueppel-like factor 2
- Guanine nucleotide-binding protein G
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
Protein: Glycine receptor alpha 3 subunit (Q9UPF3)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
RFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
Protein: Asr0485 protein (NtcA-interacting protein) (Q8YZH5)
Organism: Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Interaction partners:
- Nitrogen regulatory protein P-II
- Global nitrogen regulator
- Alr0987 protein
- Pyridoxal phosphate homeostasis protein
- DNA-directed RNA polymerase subunit omega
- Asr3387 protein
- Asl3981 protein
- Asl3609 protein
- Asl1962 protein
- All3542 protein
Sequence:
MNPENSETYINHPTWGLLYRICMVDESQDLFTTLYAQRLFFLVGNDIKAIKFQPIGRTEARMLLENRLRNLRRNGQSQEYDQLQSVFQRTFQ
Protein: Ubiquitin-conjugating enzyme E2 variant 2 (Ubiquitin-conjugating enzyme variant MMS2) (Q7M767)
Organism: Rattus norvegicus (Rat)
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 N
- Polyubiquitin-C
- E2 ubiquitin-conjugating enzyme
- Helicase-like transcription factor
- Ubiquitin-ribosomal protein eL40 fusion protein
- E3 ubiquitin-protein ligase RNF8
- Ubiquitin-conjugating enzyme E2 B
- E3 ubiquitin-protein ligase RAD18
- E2 ubiquitin-conjugating enzyme
- Ubiquitin-conjugating enzyme E2 G1
Sequence:
MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN
Protein: Immune-associated nucleotide-binding protein 9 (AtIAN9) (AIG1-like protein) (F4HT21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g51010
- Peptide upstream protein
- Exocyst complex component SEC3A
- Magnesium/proton exchanger
- Probable serine/threonine-protein kinase PBL6
- cyclin-dependent kinase
- Protein DETOXIFICATION 47, chloroplastic
Sequence:
MSLLDMGGDMMEDDWEFASSSNPKRTLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQEDGDIINVVDTPGLFDLSTAADFIGKEIVRCISLAEDGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFTGGDELEENEETLEEYLADYCPEFLKEILGICDNRLVLFNNKTTDKVKKAEQVQKLLSLVESVVKQNNGKPYSDELFHELQEEAIKLRDQKKEVELLQGYSNNEIDEFKKQIDMSYDRQLSRITEMVETKLRDTAKRLEQQLGEEQAARLEAEKRANEVQKRSSDEIKKLRENLERAEKETKELQKKLGKCINL
Protein: Acyl-CoA N-acyltransferases (NAT) superfamily protein (At5g11340) (Separation anxiety protein-like) (Q9LFM3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- N-terminal acetyltransferase A complex catalytic subunit NAA10
- N-terminal acetyltransferase A complex auxiliary subunit NAA15
- DNA-binding enhancer protein-like protein
- Cell division cycle 5-like protein
- N-terminal acetyltransferase B complex auxiliary subunit NAA25
- TATA box-binding protein associated factor RNA polymerase I subunit B-like protein
- SAGA-associated factor 29 homolog B
- TATA box-binding protein-associated factor RNA polymerase I subunit B
- TATA box-binding protein associated factor RNA polymerase I subunit B
- SAGA-associated factor 29 homolog A
Sequence:
MGAGREVSVSLDGVRDKNLMQLKILNTVLFPVRYNDKYYADAIAAGEFTKLAYYNDICVGAIACRLEKKESGAMRVYIMTLGVLAPYRGIGIGSNLLNHVLDMCSKQNMCEIYLHVQTNNEDAIKFYKKFGFEITDTIQNYYINIEPRDCYVVSKSFAQSEANK
Protein: DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (A127) (RPA135) (O54888)
Organism: Rattus norvegicus (Rat)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9H9Y6}. Chromosome {ECO:0000250|UniProtKB:P70700}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA1
- RNA polymerase I subunit E
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- RNA polymerase I and III subunit C.
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerase I subunit RPA34
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- Rrn3 protein
Sequence:
MDVDSRWRNLPSGPSLKHLTDPSYAVPPEQQKAALQDLTRAHVDSFNYAVLEGLSHAVQAIPPFEFAFKDERISLTIVDAAISPPAVPKGTICKELNIYPAECRGRRSTYRGKLTADISWAVNGVPKGIIKQFLGXVPIMVKSKLCNLYNLPPQVLIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKSRGLGYTQFGVSIHCVREEHSAVNMNLHYVENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEEDSFFKNSVSQMLRIVMEEGCHTQKQVLDYLGERFRVKLSLPDWYPNAEAAEFLFNQCICIHLKSNTDKFYLLCLMTRKLFALARGECMEDNPDSLVNQEVLTPGQLFLMFLKEKMENWLLSIKIALDKRAQKTNVSINNENLMKIFSMGTELTRPFEYLLATGNLRSKTGLGFMQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRKLLPESWGFLCPVHTPDGAPCGLLNHLTAVCEVVTKFVYTASIPALLCGLGVTPVDAAPCRPYSDCYPVLLDGVMVGWVDKELAPEVADTLRRFKVLRERRCSSLDGGGPDSHDRKAKPVPRAVPLHHSLQAGEACAEPGAGQRRARWNYGAALHEHCHLRGRGFWWSFHTPGALPSQPAEVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPCMYDHYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKFKQGDDSLVFGVKPGDPRVMQKLDNDGLPFIGAKLEFGDPYYGYLNLNTGEGFVVYYKSKENCVVDNIKVCSNDTGSGKFKCVCVTVRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMMPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGMELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTVCGRSDSIDTVSVPYVFRYFVAELAAMNIKVKLDVI
Protein: Peroxin 19 (E9AFF0)
Organism: Leishmania major
Interaction partners:
- Peroxin-13
- T-complex protein 1 subunit delta
- Peroxisomal membrane protein PEX14
- Peroxin-12
- RING-type E3 ubiquitin transferase
- AAA+ ATPase domain-containing protein
- Putative peroxisomal membrane protein 4
- Putative ATP-binding cassette protein subfamily D,member 1
- Putative ATP-binding cassette protein subfamily D,member 3
- Possible ABC transporter
Sequence:
MSDGDLDALLDEAMDMVDEQERKHEEEVRVRDAKLEDDLQKALDESSGAAGGDADMMKMFMSMLGGAGSDDASLDSFKKSVMTMVSSLEEEENLGDEDKENLQRVKELVRVMEEEDIGKANDLLEQMKQEGKLPDRNNVGDAEIDEASRRCMEMLQQLSSATQGGHLDPAATPGAASSSSAAAAAAPAGNGAEIPAEVDRATEAMASALISTLADPQFVEPIKLMRDSYGPYMDAHRSELSQEDCERYDRQRAKAQEICDLLQNPISGAEDPRLIQLLELMNKYSELGDPPRNLVEYAPKNRQEIEECQ
Protein: Iron-sulfur cluster carrier protein (P0AF08)
Organism: Escherichia coli (strain K12)
Function: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Interaction partners:
- NADH-quinone oxidoreductase subunit C/D
- tRNA-2-methylthio-N
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Methionine--tRNA ligase
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- Fe/S biogenesis protein NfuA
Sequence:
MNEQSQAKSPEALRAMVAGTLANFQHPTLKHNLTTLKALHHVAWMDDTLHVELVMPFVWHSAFEELKEQCSAELLRITGAKAIDWKLSHNIATLKRVKNQPGINGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAENQRPTSPDGTHMAPIMSHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSVHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDKGTPTVISRPESEFTAIYRQLADRVAAQLYWQGEVIPGEISFRAV
Protein: Paired mesoderm homeobox protein 2 (Paired-related homeobox protein 2) (PRX-2) (Q99811)
Organism: Homo sapiens (Human)
Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
- Homeobox protein Hox-B13
- Paired box protein Pax-9
Sequence:
MDSAAAAFALDKPALGPGPPPPPPALGPGDCAQARKNFSVSHLLDLEEVAAAGRLAARPGARAEAREGAAREPSGGSSGSEAAPQDGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAKEFSLHHSQVPTVN
Protein: Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX) (Q9Z1P4)
Organism: Mus musculus (Mouse)
Function: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Subcellular location: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
Interaction partners:
- R-spondin-1
- R-spondin-2
- E3 ubiquitin-protein ligase RNF43
- R-spondin-3
- E3 ubiquitin-protein ligase ZNRF3
- R-spondin-4
- Leucine-rich repeat-containing G-protein coupled receptor 4
- Leucine-rich repeat-containing G-protein coupled receptor 6
- Catenin beta-1
- Olfactomedin-4
Sequence:
MDTSCVHMLLSLLALLQLVAAGSSPGPDAIPRGCPSHCHCELDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLPASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLTLTGAKISSLPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGSTFQQLFNLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQWNKDDGNSVDDLHKKDAGLFQVQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALVALTVFRTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFLSIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAIVLLCVLLALTIATIPLLGGSKYNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIMTIAYTKLYCSLEKGELENLWDCSMVKHIALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGSLGKHTRFWMRSKHASLLSINSDDVEKRSCESTQALVSFTHASIAYDLPSTSGASPAYPMTESCHLSSVAFVPCL
Protein: Aspartyl beta-hydroxylase, isoform J (EC 1.14.11.16) (MIP15930p) (D1Z397)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGDVQPRKRKDKRRKRDDRKSEGDVTVLRQSSFQDDDESSHGVHITKMGNEDLHLHVHHDHGTGGHWCAKIIFFALMAVLLGLVGLIIMENRGLEDLDTPLSESRFSKVFDGWVDEHRDEHDGHDVQEPSGEALDDHDEHDDHDDHEDEDEEPLTEELEEELEEEEEPTEEDEPAADEEYEEDEDEENNAGENITAEDAEEEEEEEDNDDEGTVEATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEESVEPERSQYAAQSAPAKDNNDDDDDDDQDKNDADDGDDDEFESLAQQFENDPEDTVPAKAVESEEQDQDQADEEEPKEEGSSWLASQIKPKEAAPAPAEKEDPFEQELRKANEEMIRELNNH
Protein: Myo-inositol/proton symporter (MIT) (Q4QAR5)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRASVMLCAALGGFLFGYDTGVINAALFQMKDHFGFSEHSWQYALIVAIAIAGAFVGAFISGFISAAFGRRPCIAVADALFVIGSVLMGAAPNVEVVLVSRVIVGLAIGISSATIPVYLAEVTSPKHRGATIVLNNLFLTGGQFVAAGFTAIMVVFTSKNIGWRVAIGIGALPAVVQAFCLLFFLPESPRWLLSKGHAGRAKAVADKFEVDLCEFQEGDEVPSVSIDYRPLMARDMRFRVVLSSGLQIIQQFSGINTIMYYSSVILYDAGFRDAIMPVVLSIPLAFMNALFTAVAIFTVDRFGRRRMLLISVFGCLVLLVVIAIIGFFIGTRISYSVGGGLFLALLAVFLAVYAPGIGCIPWVIMGEIFPTHLRTSAASVATMANWGANVLVSQVFPILMGAIGVGGTFTIISGLMALGCIFVYFFTVETKGLTLEQIDNMFRKRAGLPPRFHEEGESGEHGNRHREDGDFDRMATEDVCDLSSLGNQVVSFAKAEDAFTEVAMTNRHAVSNKFEERATSSSSDPQSLKNHDEEQQTAIQAAPHEPK
Protein: Translation elongation factor 1-beta, putative (Q38B20)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GST N-terminal domain-containing protein
- Elongation factor 1 gamma, putative
- Elongation factor 1 gamma, putative
- phenylalanine--tRNA ligase
- Elongation factor 1-alpha
- Elongation factor 1-alpha 1
- Elongation factor 2
- 60S ribosomal protein L35, putative
- Translationally controlled tumor protein
- IgE-dependent histamine-releasing factor, putative
Sequence:
MSSLKEINGRLSAQPYVSGFTPSKEDARIFSEMFGSNTAVIQWAARMAAYYQAERVQLTKGATASKTSATTKAAAGDDDDIDLFGEATEEELAALEAKKKKDAAAKSSKKVIIAKSSILFDIKPWDDTVDLDGLAQKLHAIKRDGLLWGDHKLVPIAFGVKKLQQLVVIEDDKVSGDDLEEMIMSFGDDVQSMDIVAWNKI
Protein: UDP-rhamnose/UDP-galactose transporter 3 (UDP-Rha/UDP-Gal transporter 3) (Bi-functional UDP-rhamnose/UDP-galactose transporter) (Q9FIH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nucleotide-sugar transporter that transports UDP-rhamnose or UDP-galactose and UMP in a strict counter-exchange mode.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:25053812}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- DNAJ heat shock N-terminal domain-containing protein
- U6 small nuclear RNA
- ER membrane protein complex subunit 3
- Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein
- Probable sugar phosphate/phosphate translocator At1g53660
- Probable galacturonosyltransferase-like 5
Sequence:
MAAENERKSPSAVSDMGAWAMNVISSVGIIMANKQLMSSSGFAFSFATTLTGFHFALTALVGMVSNATGFSASKHVPMWELIWFSIVANVSIAAMNFSLMLNSVGFYQISKLSMIPVVCVMEWILHSKRYSREVKISVVVVVVGVGICTVTDVKVNAKGFICACVAIFSSSLQQILIGSLQKKYSIGSFELLSKTAPIQAFSLLVVGPLVDYLLSGKFIMKYNMSSGCFLFILLSCGLAVFCNISQYLCIGRFSAVSFQVIGHMKTVCILTLGWLLFDSAMTFKNVAGMIVAIVGMVIYSWAMELEKQSIIAAKALNSVKHSLTEEEFELLKEGVETTQSKDVELGRTKD