Protein: Protein lin-12 (Abnormal cell lineage protein 12) (Notch-like protein lin-12) [Cleaved into: lin-12/Notch intracellular domain] (P14585)
Organism: Caenorhabditis elegans
Function: Essential signaling protein which has a major role in many developmental processes; involved in cell fate decisions that require cell-cell interactions. Probable membrane-bound receptor for putative ligands lag-2, apx-1, dsl-1 and osm-11. Upon ligand activation, and releasing from the cell membrane, the lin-12/Notch intracellular domain (NICD) forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes. Required for ventral cell fates in the postembryonic mesodermal lineage (M lineage) and in uterine precursor cells. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Best known for involvement in cell-fate decisions during development, but also plays roles in other events. Regulates recovery from the dauer larval state. Modulates chemosensory avoidance of octanol and quiescence during molting. Promotes basement membrane mobility during tissue remodeling. Involved in establishing left-right asymmetry during intestinal organogenesis.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:32053105}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the apical cell membrane of vulval precursor cells. {ECO:0000269|PubMed:32053105}.; SUBCELLULAR LOCATION: [lin-12/Notch intracellular domain]: Nucleus {ECO:0000305|PubMed:16530045}. Note=Becomes localized to the nucleus during signal transduction. {ECO:0000305|PubMed:16530045}.
Interaction partners:
- Suppressor of hairless protein homolog
- Protein lag-3
- Presenilin sel-12
- Disintegrin and metalloproteinase domain-containing protein 10 homolog
- Numb-related protein 1
- Nicastrin
- Presenilin hop-1
- Gamma-secretase subunit pen-2
- Disintegrin and metalloproteinase domain-containing protein 17 homolog
- Presenilin spe-4
Sequence:
MRIPTICFLFLLISLSKSLHIGSCLGLICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKDSLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRITVQMDPKEFQVTGGQSLMEISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVVVYLEVQENCDTGKCLYKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMPPMENEEKNRKNHQSITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEGRDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDRCRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGSTSTPSPQHFMNTTHTTPTSLNYLSPEYQTEAGSSEAFQPQCGAFGNGEMWYTRASTSYTQMQNEPMTRYSEPAHYF