wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleobase/nucleoside transporter 8.1 (Q8MUN2)
Organism: Trypanosoma brucei
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MALGFSSAGEVYMYATCILLGVSLLMPLNALVSAPRFMVDYYKYVSGKEDSEPNLPFFWKNIFTFYNVVSLASQVIAGPTVLTRAARRLSLSVRFALSITLMMSEVFVVLMMPVIKVPQTVAIVLLCLVTIFAGIGKSYHEATCYVLVASMPSKFMSAVMFGVSLCGVITSTLQCIIKASMEDTYESVLTQSYIYFSLGLLIMAGTLAMALCLRYNSYAQEHVAEYRMLKLQEQGVDAESQNDEKEPVAEGKGEGEGKSEGAMTTAEQLTATAVMPVARIIRMMLVTVFCGFFLTLFIFPSLIIPIDRDHNWFATIAILLYNCGDAIGRFSTSFKCVWPPRRALLYATFARFIFVLPFMLCIYQYIPGHVGPYIFSFLLGLTNCVGAMSMVYGPITPGLETAGQKLMAGQLMGISLLSGIAAASVLAMIVVVFLP
Protein: Papain (EC 3.4.22.2) (Papaya proteinase I) (PPI) (allergen Car p 1) (P00784)
Organism: Carica papaya (Papaya)
Function: Cysteine proteinase with a high level of diversity in substrate specificity, an amino acid bearing a large hydrophobic side chain at the P2 position is preferred.
Interaction partners:
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
Protein: Placental lactogen (O77687)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MAPASSHREHQWTCNLVRGSRLLLLLVVSNLILCQGQAQHPPYCRNQPGKCQIPLQSLFDRATTVANYNSKLAGEMVNRFDEQYGQGINSESKVINCHTSSITTPNSKAEAINTEDKILFKLVISLLHSWDEPLHHAVTELANSKGTSPALLTKAQEIKEKAKVLVEGVEVIQKRIHPGEKNEPYPVWSEQSSLTSQDENVRRVAFYRLFHCLHRDSSKIYTYLRILKCRLTSCET
Protein: Serine protease 41 (EC 3.4.21.-) (Testis serine protease 1) (TESSP-1) (Q7RTY9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHSTPRPNPSQLLLLLALLWAP
Protein: CD74 molecule, major histocompatibility complex, class II invariant chain a (Iclp1 protein) (Invariant chain-like protein 1) (Q9PUT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS5
- Ribosomal protein L4
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL14
- 40S ribosomal protein S15
- Ribosomal protein S3
Sequence:
MEPDHQNESLIQRVPSAETILGRGDARNSNTKALKITGLTVLACLLLAGQALTAYMVWGQKQHINALTSGQEKLKAELTRKMSAGAPKAMSLPMNSMPLLKDYSDPTSDQTAVKSKSVPLTKLRPIYSNQREGSGQVDGSRLMPKMMHLPMRSMPLLVNADEDVKSSPESVVELETKCKLESEREVRPGFFKPACDEEGNYMPMQCWHSTGYCWCVTKDGTEIEGTRIRGRPQCESV
Protein: PH-sensitive chloride channel 1, isoform L (M9PFR7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGCVFEAAKEQPHKPRSRQLRRNQCRGKAEKAAAGTRGKVAVRGNNDKPAEDIKIKDNYQQNHKTQTETQTEVAAVVAIATDAGAETETETEAEAQKEPATGPEHLKAAAQVLLTIRQARQENNKHSSSQVAETHKDEGEDALARQGSIVDTAAGRIGIDIAATTIQVAERHEDGQHWQQHNVRRRRRQPDPAAHPASITKLSAISLHFHALAALAKTLQKHEDLSPVQDRQPLAYRAWQEHPYAETQMPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTAAATQSETGALDKHPIFDESSSDKEILDLLLEKKRYDKRLLPPVNGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLPGEKRQNAGAPNEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHYKGFS
Protein: Ribosomal Protein, Small subunit (O17218)
Organism: Caenorhabditis elegans
Interaction partners:
- Ribosomal protein
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS16m
Sequence:
MVRMNVLADALNAINNAEKRGKRQVLIRPASKVIVRFLTVMMKHGYIGEFEIVDDHRAGKIVVNLTGRLNKASVISPRLNIRLNDLEKYTNTLLPSRQFGYLILTTSAGIMDHEEARRKHLGGKILGFFF
Protein: MHC class I alpha chain 2 (MHC class I antigen) (MHC class I glycoprotein) (MHC class I molecule) (Major histocompatibility complex class I glycoprotein haplotype B21) (Q95601)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGSCGALGLGLLLAAVCGAAAELHTLRYIRTAMTDPGPGLPWFVDVGYVDGELFMHYNSTARRAVPRTEWIAANTDQQYWDRETQIVQGSEQINRENLDILRRRYNQTGGSHTVQWMSGCDILEDGTIRGYHQAAYDGRDFVAFDKGTMTLTAAVPEAVPTKRKWEEGGYAEGLKQYLEETCVEWLRRYVEYGKAELGRRERPEVRVWGKEADGILTLSCRAHGFYPRPIVVSWLKDGAVRGQDAQSGGIVPNGDGTYHTWVTIDAQPGDGDKYQCRVEHASLPQPGLYSWEPPQPNLVPIVAGVAVAIVAIAIVVGVGFIIYRRHAGKKGKGYNIAPDREGGSSSSSTGSNPSI
Protein: Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Protein-tyrosine kinase receptor MPK-11) (CD antigen CD334) (Q03142)
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18186042}; Single-pass type I membrane protein {ECO:0000269|PubMed:18186042}. Endosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane. {ECO:0000250}.
Interaction partners:
- Fibroblast growth factor 15
- Fibroblast growth factor 2
- Beta-klotho
- Fibroblast growth factor 1
- Fibroblast growth factor 18
- Fibroblast growth factor 23
- Fibroblast growth factor 6
- Fibroblast growth factor 8
- Fibroblast growth factor 4
- Fibroblast growth factor 17
Sequence:
MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILYVSGSLVLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGDASSTCSSSDSVFSHDPLPLEPSPFPFSDSQTT
Protein: Acetylcholine receptor subunit epsilon (P20782)
Organism: Mus musculus (Mouse)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Acetylcholine receptor subunit alpha
- 43 kDa receptor-associated protein of the synapse
- Protein Dok-7
- Muscle, skeletal receptor tyrosine-protein kinase
- Acetylcholinesterase collagenic tail peptide
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit delta
- Acetylcholine receptor subunit gamma
- Neuronal acetylcholine receptor subunit alpha-6
- Neuronal acetylcholine receptor subunit beta-3
Sequence:
MAGALLGALLLLTLFGRSQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIDWHDYRLNYSKDDFAGVGILRVPSEHVWLPEIVLENNIDGQFGVAYDSNVLVYEGGYVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNTINKIDIDTAAFTENGEWAIDYCPGMIRRYEGGSTEGPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLELLPRLLGSSPPPEDPRTASPARRASSVGILLRAEELILKKPRSELVFEGQRHRHGTWTAALCQNLGAAAPEIRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPYPPCIQP
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (Q383V4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Methyltransferase type 11 domain-containing protein
- NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial
- Acyl-CoA dehydrogenase, mitochondrial, putative
- Protein arginine methyltransferase NDUFAF7
- Phytoene synthase
- Acyl carrier protein
Sequence:
MRCSLVQRGGGYSNIDWKTRARRTVQRFVRRYVPDPRDDPLTEVPMNEETYKKTYLQQEGGVRVGIRPGQLVEDYMAERDKKWLEGQRLTTGRLVEEQKLPTTSDGQLFYGTGTRETYMDVGTANKHVKPPKPSDYESDEELILMRRQLQVENEAEYRKFVAETKRAEIKMEETRKRRRPHPTDPTYDPFKITPGYRPQDSAALAQWLKRQRESGKTASGLSLQTREGQERFYNEEKMATQFHANPFSARIEEPRGLSRMRITAYTPDSIFVNDKEVIGSCIVTDKSYYHWNVSSFEEVNERTLALLLHLYPVPDVIFLGTGRNLHFIDEELRIAFQKRGSIIHCLTTPQACGHFGVQLSVSRRAALAVINPIPTNGYGTECFGDFIENDMFSLSDTQLGIPPIKQFSSALFKPNKVAEKYRHMQGTGFGPKYHQLSDGRLVRPGTSGTKLRPLIEPGEDVQWETLPSYYHWYPKEHLHDYIENTTMREIQGKPTGDPTERRLQQALRGEKSDKRESPTPDIAPWDSASIPITKFPHERNDDEVVVEDPKTGRIIGMDRNTYERWRVMMQERREGKPESDPVEYDQERFVTNKDGVVFDLSKVKYRPIFEGRWNPRRPQSTGRTNPIMV
Protein: Y' element ATP-dependent helicase YPR204W (EC 3.6.4.12) (Q08995)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- Putative uncharacterized protein YPR203W
- Putative uncharacterized protein YPR202W
- EST/SMG-like protein 1
Sequence:
MADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSNTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTNSSTNATTTASINVRTSATTTESTNSNTNATTTESTNSSTNATTTEGTNSNTSATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
Protein: Zinc finger protein (Q585W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTEVPGIPVTITCGICFGILHDPVTLSCKHSFCASCVLGRLECLEGRDFICLLCSTKQEHINNETLPKLVDNELRAYVKARVEGLAQQPVCQWCQEVAAAIQCDECAGAYCMDCNTAVHKNATKRHHTFFPLDDAQETRKLYRCCGVQGHEEYRLEFYCKVCESLCCAYCLLTGPHNGHESISVPEAAAIFRNRAPGEITLMTDKKERLEKKVNQLNVVTTRYFDSLEEVKKSIKERFSQLQMMVSQREKELLEALGSLCDTGHASLNQCRGRVLAKANAINESVVLLQHMKRGCSDYKILENRSYLSYHLSEETPDVEGLGFKFFEVGDFGLPQFKLFLDLRSEEHSKNGIRRDTNLRRCIPHSQVDDDSRPQSGKVLNVCAQDGSMIPLRTGRRFTLTEREGIDLKVLNSVVHVTAQPNEADSLKQIGIRTEQTVEEIARLFPEERGRVTWRVQLGKGFDKSFVGVVERTDTSLVPGGFYWKPTKLGVVDGGIGRIGQSFKELPVCCIGDVLTFTYSVDEGSLGINVNGKYYGNLVTSLHPRISPCFILYPKESLIVSC
Protein: [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) (A0A0G2K5I7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone H3
- Histone H3.1
- Histone H3
- Lysine-specific histone demethylase
- Histone H3.3
- Histone H3
- Histone H3
- Nuclear receptor corepressor 1
- Similar to H3 histone, family 3B.
- E3 ubiquitin-protein ligase RNF8
Sequence:
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRTSYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPERYKLWKAGKDSTVIDHTLPTPEAAEFLKDSGLTPRAGNEECPEEDSEAAEQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEELSSGQYEMTECQATLAPVRPTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAAALDLSVNPESVEGRLVFSGSKKKASSSLGSSSSQDSVSSDSETTESVSCQGQEKTVLTVHSYSRGDGKAAPGEPSVKRQRSAPRSISEQELAEVADEYMLSLEENKKTKGRRQPLSKLPRHHPLVLQECGSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNELMAQQAPHCAVCMIFQTYHQVEFGGFSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
Protein: Interleukin-17F (IL-17F) (Cytokine ML-1) (Q96PD4)
Organism: Homo sapiens (Human)
Function: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q7TNI7}.
Interaction partners:
- Interleukin-17 receptor C
- Interleukin-17 receptor A
- Interleukin-17A
- Interleukin-22
- Interleukin-17 receptor E
- Interleukin-25
- Interleukin-6
- Interleukin-23 receptor
- Interleukin-23 subunit alpha
- Interleukin-17 receptor B
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
Protein: Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)] (Q14626)
Organism: Homo sapiens (Human)
Function: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
Subcellular location: [Interleukin-11 receptor subunit alpha]: Membrane {ECO:0000269|PubMed:26876177}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:26876177}.; SUBCELLULAR LOCATION: [Isoform HCR2]: Secreted {ECO:0000269|PubMed:26876177}.
Interaction partners:
- Interleukin-11
- UDP-glucose 4-epimerase
- Galactose-1-phosphate uridylyltransferase
- Interleukin-6 receptor subunit beta
- Interleukin-6
- N-acetylgalactosamine kinase
- Cardiotrophin-1
- Galactokinase
- Ciliary neurotrophic factor
- Interleukin-6 receptor subunit alpha
Sequence:
MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL
Protein: Trehalose phosphorylase (EC 2.4.1.231) (Trehalose synthase) (TSase) (O75003)
Organism: Grifola frondosa (Maitake) (Polyporus frondosus)
Function: Reversibly catalyzes the synthesis and degradation of trehalose from glucose and alpha-D-glucose 1-phosphate. The equilibrium lies in the direction of trehalose synthesis.
Interaction partners:
Sequence:
MAPPHQFQSKPSDVIRRRLSSAVSSKRPNIPGYTSLTPMWAGIAGAVVNNNTQFEVAISIHDSVYNTDFASSVVPYSPNEPEAQAGIIEKHVLETLRKFSTEHMCKFLGAGVTVILLREAPNLCTRLWLDMDIVPIVFNIKPFHTDSITRPNVRHRISSTTGSYVPSGAETPTVYYDPAQLQDPNKLSANVQTRLPIPRTVDEQADSAARKCIMYFGPGNNPRLQIGPRNQVAVDAGGKIHLIDDIDEYRKTVGKGTWNSVIKLADELREKKIKIGFFSSTPQGGGVALMRHAIIRFFTALDVDAAWYVPNPSPSVFRTTKNNHNILQGVADPSLRLTKEAADNFDSWILKNGLRWTAEGGPLAPGGVDIAFIDDPQMPGLIPLIKRIRPDLPIIYRSHIEIRSDLVHVKGSPQEEVWNYLWNNIQHSDLFISHPVNKFVPSDVPLEKLALLGAATDWLDGLSKHLDAWDSQYYMGEFRNLCVKEKMNELGWPAREYIVQIARFDPSKGIPNVIDSYARFRKLCVDKVMEDDIPQLLLCGHGAVDDPDASIIYDQVLQLIHAKYKEYAPDIVVMRCPPSDQLLNTLMANAKFALQLSTREGFEVKVSEALHAGKPVIACRTGGIPLQIEHGKSGYLCEPGDNAAVAQHMLDLYTDEDLYDTMSEYARTHVSDEVGTVGNAAAWMYLAVMYVSRGVKLRPHGAWINDLMRTEMGEPYRPGEPRLPRGELHVQG
Protein: EMBRYO SURROUNDING FACTOR 1.2 (Maternally expressed family protein 1.2) (Maternally expressed gene 1.2) (A8MQX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maternally-contributed central cell peptide regulating suspensor development and correct auxin distribution in early developing embryos.
Interaction partners:
- EMBRYO SURROUNDING FACTOR 1-like protein 6
- At4g20420
- F-box associated ubiquitination effector family protein
- Similarity to tapetum-specific protein
- EMBRYO SURROUNDING FACTOR 1-like protein 8
- EMBRYO SURROUNDING FACTOR 1-like protein 9
- EMBRYO SURROUNDING FACTOR 1-like protein 10
- Uncharacterized protein AT4g11020
- Transmembrane protein
- Transmembrane protein
Sequence:
MKSQTVLISIFIFSFFALHQCMQMDVGEIEGSNKISIGKCVPAQCSVSFFKRDCWCCFRDQSMCSKTQKECESNPRCPPLKF
Protein: Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (Heat shock 70 kDa protein 9) (Q5XJ12)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLSVSRTARLVRNVSCSQKTSSGVSDLIKKACLNGWTQKTLQTAARRHYASEAIRGAVIGIDLGTTNSCVAVMDGKNAKVLENAEGARTTPSVVAFTSDGERLVGMPAKRQAVTNPNNTLYATKRLIGRRFDDAEVQKDLKNVPYKIVRASNGDAWLEVHGKMYSPSQAGAFILIKMKETAESYLGQSVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGLDKTQDKIIAVYDLGGGTFDISVLEIQKGVFEVKSTNGDTFLGGEDFDQHLLRHIVKEFKKESGVDLMKDNMALQRVREAAEKAKCELSSSLQTDINLPYLTMDASGPKHLNMKLTRSQFEGIVADLIRRTVAPCQKAMQDAEVSKSDIGEVLLVGGMTRMPKVQQTVQDLFGRAPSKSVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMATDNKVLGQFTLVGIPPALRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRRKDRVEAVNMAEGIVHDTESKMEEFKDQLPADECNKLKEEISKVRELLSRKDTETGENIKQAATSLQQASLKLFEMAYKKMASEREGSSGSSSSGEAGEKKEGQQ
Protein: Elongin-A2 (EloA2) (RNA polymerase II transcription factor SIII subunit A2) (Transcription elongation factor B polypeptide 3B) (Q8IYF1)
Organism: Homo sapiens (Human)
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Elongin-C
- Elongin-B
- Transcription elongation factor A protein 1
- Transcription elongation factor A protein 2
- Superkiller complex protein 8
- Cullin-5
- RNA polymerase-associated protein LEO1
- Parafibromin
- DNA-directed RNA polymerase II subunit RPB1
- von Hippel-Lindau disease tumor suppressor
Sequence:
MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRMPEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR
Protein: Uncharacterized protein C24B11.05 (Q09893)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Putative purine nucleoside phosphorylase
- NAD-capped RNA hydrolase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- IMP-specific 5'-nucleotidase 1
- Probable nicotinate phosphoribosyltransferase
- Putative nicotinamide mononucleotide adenylyltransferase
- Inosine-5'-monophosphate dehydrogenase
- Amidophosphoribosyltransferase
Sequence:
MTVEQKIIFFDLDNCLYPKSYKIHNMMAARITAFFSDKLGIPTEEAERLREVYYRHYGIAIRGLVLHHEIDAVDYDQRVDQSLPLEKVIKKDEVLREMLLELRKKYKCWIFTNAYIVHANRVLKYLGIEDCFDGITYCDYNAKDLIAKPMPEMYERVMREAGVTDKDKCIFVDDSYGNILGAREFGWKYTVQLVEHGDPLPQPQAGSHVIRDIHKFKHLLDEIDGE