wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-binding cassette, sub-family B (MDR/TAP), member 4 (E7F1E3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- RUN domain-containing protein 3B
- Sulfotransferase
- Cytochrome P450, family 3, subfamily A, polypeptide 65
- Mitochondrial glutathione transporter SLC25A40
Sequence:
MGKKSKLKVSSDKKEENGDVSGEKNGKEEKEEKEKLEMVGPIELFRYADSIDILLMMLGLIMSMANGAVLPLMVIVFGDMTDSFVDDTLLDNLKNITLPPNFTFPETSNITLGEKMTTHAIYYSIMGFVVLVAAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKLGMLIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAEEVLSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTLILGGEYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFSEEGYKLDVVKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYDPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAYNFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQMFKSTEVAEEDSEEMTMDEKSPSVSSMNERTLFRQKSRSGSEKELKEEEKPTEEEKVPNVSFLTVLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAEPDQNLVRQRCDLYSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTKNSVGALTTRLAADTAQVQGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAIQMKLLAGHALKDKKELEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVFGLTFSFSQAMIYFAYAGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLMLINRAPAIDNSSEDGDKPDKFEGNVGFEHVYFKYPSRPDVPVLQGLKLRVKKGQTLALVGSSGCGKSTTIQLLERFYDPQQGRVMLDDNDAKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGTHQQLLSQQGAYYTLVTSQMSH
Protein: Uncharacterized protein, isoform B (A0A0B4KFE8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- LD40944p
- IP01295p
- Uncharacterized protein, isoform B
- RE17222p
- UT01871p
Sequence:
MDRKKVLELDKICRLCISERKEMRPLFSEKVPEMLMDCTSVRVEPTEGWPDKICVQCVHAVSRNHAFKTLVERSDKELREYIRGLTVALVMEEQQQQEAANAKQQLQLERKQQRQLQKQQKILEEQLQQQIVQQQQHQPPAKPKLKPLLRKGSRQQKQRHLEAAPAPQSVPQPAPQPQMQLMQEHAPQQPTMQQQIQQIHMPTLQPAPAQLLSAAGATTTMPQQILLPNGQLITTAQIVAPQLAQIISTAPQSTTNGQATAAQSQFLPQLLQTPNGQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMGQHVGASLGDADVQLLEDGCEVEDEELEDVYEQLDSKADHSFETIVLDDDQQQDFLKDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFIIEEIQLEDDEMLDDPDGEEIDQDCEYIGEEQDPHLSGDVDDDLEYSIMEPPDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQIPAGVTLEPCDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTSPLGSGRYICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQQRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFKCGECGSLYDNVDSLQLHVESTDHSAEVQISGQDDAFSGAVSIVSNGTTDMSNMMATGQGTTLAGGTGDTHAVVMGSSGEVYFVTQAXPAEFAAAGAPGNGECLLGI
Protein: Potassium voltage-gated channel protein shk-1 (Q8I4B0)
Organism: Caenorhabditis elegans
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P08510}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08510}.
Interaction partners:
- Ubiquitin-like domain-containing protein
- Ion_trans_2 domain-containing protein
- Voltage-dependent L-type calcium channel subunit alpha
- Disks large homolog 1
- G-protein coupled receptors family 1 profile domain-containing protein
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL21
Sequence:
MRFGGQRRCIESSDDNDSIDSMSIQQKNKEKEEWKWAQSLARRLEQVLNVHPEKYQNGCSSQRPSRQPSPVEQLAPIRSHSADFGRAAEMASGNSEEGKGMLLRNGDDRIRLPSPQRGTPDTSSTQGHPYTDQIVTINVSGMRFQTFESTLSRYPNSLLGDRNKRQHFFVSDTNEFFFDRHRTTSSSFTFEIRNYLFESILYIYQSGGRVKRPEIVPIDIFLKEMRFFQMGDDLLEEFWIAEGYEKPKEVMMPNNKTQRKIWELMEYPDSSLSARIIAFISIAVIALSIISFCWETVPSDIEEKPINNSATAELLDEMDEKHYSPFFWIELMCILWFTIELILRFISCPCKVTFATSVLNIIDFVAIAPFFVNFFFADTSKSNSSMSFAVLRVLRLVRVFRVFKLSRHSVGLQILGKTFRSSVQEFCLLIFFMAIALVLFASGMYFAEQGEPNSKFTSIPASFWFVLVTMTTVGYGDLVPLSPFGKVVGGMCAMIGVLTLALPVPIIVANFKHFYRQENRLASMKSKGDDADDDIA
Protein: Galectin (M9NCX9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTCCCGKQKRSQDETYQRFKNEDASFYEYADAVPKYFNDQIGKLSEGISFTVTGNLSVNCERFSINLVYNNDSRDVALHINPRLPQNYIVRNTKVQDIWGNEEVSSALPFLLSRGEEFSIQVLVTEACYMISVNGQHFAAYTHRIPYRDVRILEVKGDVSNVEMKRTLVLKYPERLPQSEANNIELHIDDGINEIDASVEETVKIPHEWCIISAPNTQSDSSPKRNNSSNDLGLTLPYYGALPPNSLVDGRCLKIEGRVRLLPHSFYINLQQGQDIWPHPVIAFHLNPRFSKASSGAIGKAVVCRNAWLNGAWAQEERSEFDTNFRPGRSFCLAIVCTKTSFEVYVNRQFMTDFKYKVSPEVVDTVYIQGDVKLWNVTLEKNQMIKGKNMRVYQNPWFFSE
Protein: ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) (P35434)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase subunit ATP5MPL, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
Sequence:
MLPAALLRHPGLRRLVLQARTYAQAAASPAPAAGPGQMSFTFASPTQVFFDGANVRQVDVPTLTGAFGILASHVPTLQVLRPGLVMVHAEDGTTTKYFVSSGSVTVNADSSVQLLAEEVVTLDMLDLGAARANLEKAQSELSGAADEAARAEIQIRIEANEALVKALE
Protein: Diamine oxidase [copper-containing] 1, peroxisomal (NtDAO1) (EC 1.4.3.-) (Copper methylamine oxidase) (EC 1.4.3.21) (N-methylputrescine oxidase 2, peroxisomal) (NtMPO2) (EC 1.4.3.-) (A0A1S3XSG2)
Organism: Nicotiana tabacum (Common tobacco)
Function: Involved in putrescine catabolism in peroxisomes. May also be involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Oxidizes preferentially non-N-methylated amines.
Subcellular location: Peroxisome {ECO:0000269|PubMed:24287136}.
Interaction partners:
- Putrescine N-methyltransferase 4.
- Putrescine N-methyltransferase 1
- Putrescine N-methyltransferase 2.
- Aldehyde dehydrogenase family 2 member B4, mitochondrial isoform X1
- Aldehyde dehydrogenase family 2 member B7
- Aldehyde dehydrogenase family 2 member B4, mitochondrial-like
- Aldehyde dehydrogenase family 2 member B7, mitochondrial-like
- Aldehyde dehydrogenase family 2 member B4, mitochondrial isoform X1
- Aldehyde dehydrogenase family 2 member B7, mitochondrial-like
- Aldehyde dehydrogenase
Sequence:
MATTKQKVTAPSSSTAPCCPSTSILRREATAAVAGVGDGLQNWNNVPSVDDKQKKTASSALASLASTEPLSSNTSTKGIQIMTRAQTCHPLDPLSAAEISVAVATVRAAGETPEVRDGMRFIEVVLLEPDKSVVALADAYFFPPFQSSLMPRTKGGSLIPTKLPPRRARLIVYNKKTNETSIWIVELNEVHAAARGGHHRGKVISSNVVPDVQPPIDAQEYAECEAVVKSYPPFRDAMRRRGIDDLDLVMVDPWCVGYHSEADAPSRRLAKPLVFCRTESDCPMENGYARPVEGIYVLVDVQNMQIIEFEDRKLVPLPPADPLRNYTAGETRGGVDRSDVKPLHIIQPEGPSFRISGNYIEWQKWNFRIGFTPREGLVIHSVAYLDGSRGRRPIAHRLSFVEMVVPYGDPNDPHYRKNAFDAGEDGLGKNAHSLKRGCDCLGYIKYFDAHFTNFTGGVETTENCVCLHEEDHGMLWKHQDWRTGLAEVRRSRRLTVSFVCTVANYEYAFYWHFYQDGKIEAEVKLTGILSLGALQPGEYRKYGTTILPGLYAPVHQHFFVARMNMAVDCKPGEAHNQVVEVNVKVEEPGKENVHNNAFYAEETLLRSELQAMRDCDPFSARHWIVRNTRTVNRTGQLTGYKLVPGPNCLPLAGPEAKFLRRAAFLKHNLWVTQYAPGEEFPGGEFPNQNPRVGEGLASWVKQDRPLEESDIVLWYIFGITHVPRLEDWPVMPVEHIGFVLQPHGFFNCSPAVDVPPPSACDSESRDSDVTETSVAKSTATSLLAKL
Protein: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) (Q726X4)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Interaction partners:
- 2-isopropylmalate synthase
- 3-isopropylmalate dehydrogenase
- 3-isopropylmalate dehydratase small subunit
- Ketol-acid reductoisomerase
- Dihydroxy-acid dehydratase
- Citramalate synthase
- Pyruvate:ferredoxin oxidoreductase
- Branched-chain-amino-acid aminotransferase
- L-lactate dehydrogenase
- Pyruvate kinase
Sequence:
MAHTLAQKILQRHTDEAITDAGQIVRCRVSMVLANDITAPLAIKSFRAMGAKRVFDKDRVALVMDHFTPQKDIEAAQQVKLTREFAREMGVTHYYEGGDCGVEHALLPELGLVGPGDVVVGADSHTCTYGGLGAFATGLGSTDVAGAMALGETWFKVPPTIRATFTGTLPAYVGAKDLILTLIGAIGVDGALYRALEFDGAAIEALDVEGRMTMANMAIEAGGKAGLFAADAKTLTYCTTAGRTGDTAFSADAGAVYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDVTVQQVVIGSCTNGRIGDLREAAAVLRGRKVSRDVRCIVLPATPGIWRQALREGLIETFMEAGCIVGPATCGPCLGGHMGILADGERAIATTNRNFKGRMGSLESEVYLSGPATAAASAVTGVITDPSTL
Protein: Heat-labile enterotoxin B chain (LT-B, porcine) (LTP-B) (P32890)
Organism: Escherichia coli
Function: The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
Interaction partners:
Sequence:
MNKVKCYVLFTALLSSLYAHGAPQTITELCSEYRNTQIYTINDKILSYTESMAGKREMVIITFKSGETFQVEVPGSQHIDSQKKAIERMKDTLRITYLTETKIDKLCVWNNKTPNSIAAISMKN
Protein: Uncharacterized protein YggL (P38521)
Organism: Escherichia coli (strain K12)
Interaction partners:
- tRNA
- D-2-hydroxyglutarate dehydrogenase
Sequence:
MAKNRSRRLRKKMHIDEFQELGFSVAWRFPEGTSEEQIDKTVDDFINEVIEPNKLAFDGSGYLAWEGLICMQEIGKCTEEHQAIVRKWLEERKLDEVRTSELFDVWWD
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A2A121)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSRNIEWEHFEEREKGHRSPRGSGGSHSGSRGNGIVPSPAHSAHCSFYRTRTLQSLTSEKKAKKVRFYRNGDKYFKGLVYAVSGDRFRSFDALLMELTRSLSDNVNLPQGVRSIYTADGGKKITSLDDLVEGESYVCASNEPFRKVDYTKNVNPNWSVNVKTGASRSMPSLTATKNELRERESKDYIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGAVKRLYTLEGKQIICLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSGKASTAFITECQVIKSSYSARSAPPVRYSGSKSPGTGRRSKSPGSARRTAGHFSTNSQSPVKSPINGAPNSQITTPKSAKSSSSSPTSPRSMRNFKIPTHHSSAGNVNGSSETPQHHNNSLSPEVNGNRNLAASTILDKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMNTALDKETIQLSHRRQDRNPPRPEKRPSSTNPERRRSNRGRSSVQSEDSRSAAPIEPATSANPSAPAALPSDPSPQFHECNTESEASKDLLKEE
Protein: Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (Q8SYP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein bS6m
- Mitochondrial ribosomal protein S11
- Small ribosomal subunit protein mS29
- LD06441p
- 28S ribosomal protein S14
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS9m
Sequence:
MSQTLIRRLFNQACSRNIFILNQSLLSSHEPILPGYIGLRNTSFFNKLPAEDIWRGVTAVSNAGKKRGRGKGSGKKVAKDLNKGQSIGFGKCGRIWPGLNSPLIRGNELINQQKLNENLDRENGILKLRDSMGSFKLMKLNPIDRGWSGSKMPGRSIGPPDPVGDEEFVSFDTRVLENKIVFIMKGNMGRKRRYSVLSVTGNGNGLAGFATAKAPEVRTALRKSKNRAGQKLINISLCENRTIFHDFRTDFGKTKIFCFQKPDGYGLVCHRAIQTICKVIGIKDLYAKIEGSTNIQNIAKAFFIGLMTQRSYQYIANETNSNIVQLQKTRNRFIDVKGMPFPNSTLTQNTQEIDYMHFTLGNQIVLQRKGTVPFYVYSKGHDLHQFKKERFRNQVNVRLHKLVNAYD
Protein: Serpin family B member 13 (C9JL93)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTCQDTALSICVRCPATTVSPKTRGLAKIIMDSLGAVSTRLGFDLFKELKKTNDGNIFFSPVGILTAIGMVLLGTRGATASQLEEVFHSEKETKSSRIKAEEKEVIENTEAVHQQFQKFLTEISKLTNDYELNITNRLFGEKTYLFLQKYLDYVEKYY
Protein: Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-specific-processing protease 12) (P39538)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ubiquitin carboxyl-terminal hydrolase that recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 2
- Ubiquitin carboxyl-terminal hydrolase 6
- Mitochondrial distribution and morphology protein 30
- Cell division control protein 48
- Ubiquitin carboxyl-terminal hydrolase 3
- Mitofusin FZO1
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL3m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS16m
Sequence:
MGSSDVSSRECSLVYNEDPDFTDGTTPCDRLGVDLMNVLDDKDEIKQESVPVSDREIEDTESDASAVSSFASANELIAEPHAASETNLGTNGQDGRNVLEQQRDVVARLIEENKETQKEGDKVCIVPKVWYDKFFDPDVTDPEDIGPINTRMICRDFENFVLEDYNRCPYLSIAEPVFNFLSEIYGMTSGSYPVVTNLVINQTTGELETEYNKWFFRLHYLTEKQDGRKRRHGQDDSIMYLSMSALNLVRDLVEKSMNLFFEKADHLDVNAVDFKIWFVSEGSDIATDSNVSTFLNSSYEITPLQFLELPIKKLLIPDMFENRLDKITSNPSDLVIEIKPIEGNHHWPSNYFAYNKLEPASGTTGLVNLGNTCYMNSALQCLVHIPQLRDYFLYDGYEDEINEENPLGYHGYVARAFSDLVQKLFQNRMSIMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDSQEFLAFLLDSLHEDLNRIIKKEYTEKPSLSPGDDVNDWNVVKKLADDTWEMHLKRNCSVITDLFVGMYKSTLYCPECQNVSITFDPYNDVTLPLPVDTVWDKTIKIFPMNSPPLLLEVELSKSSTYMDLKNYVGKMSGLDPNTLFGCEIFSNQIYVNYESTESNAQFLTLQELIKPADDVIFYELPVTNDNEVIVPVLNTRIEKGYKNAMLFGVPFFITLKEDELNNPGAIRMKLQNRFVHLSGGYIPFPEPVGNRTDFADAFPLLVEKYPDVEFEQYKDILQYTSIKVTDKDKSFFSIKILSVEKEQQFASNNRTGPNFWTPISQLNLDKATDIDDKLEDVVKDIYNYSSLVDCAEGVLMQVDDEGDTEGSEAKNFSKPFQSGDDEENKETVTNNENVNNTNDRDEDMELTDDVEEDASTEPELTDKPEALDKIKDSLTSTPFAILSMNDIIVCEWSELGSNEAFSDDKIYNWENPATLPNKELENAKLERSNAKERTITLDDCLQLFSKPEILGLTDSWYCPTCKEHRQATKQIQLWNTPDILLIHLKRFESQRSFSDKIDATVNFPITDLDLSRYVVYKDDPRGLIYDLYAVDNHYGGLGGGHYTAYVKNFADNKWYYFDDSRVTETAPENSIAGSAYLLFYIRRHKDGNGLGSSKLQEIIQKSRHGYDERIKKIYDEQMKLYEFNKTDEEEDVSDDMIECNEDVQAPEYSNRSLEVGHIETQDCNDEDDNDDGERTNSGRRKLRLLKKVYKNNSGLGSSSTSEISEGCPENEVADLNLKNGVTLESPE
Protein: Zinc finger protein 75A (Q96N20)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MYFSQEEWELLDPTQKALYNDVMQENYETVISLALFVLPKPKVISCLEQGEEPWVQVSPEFKDSAGKSPTGLKLKNDTENHQPVSLSDLEIQASAGVISKKAKVKVPQKTAGKENHFDMHRVGKWHQDFPVKKRKKLSTWKQELLKLMDRHKKDCAREKPFKCQECGKTFRVSSDLIKHQRIHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKSFSQNTNLHTHQRTHTGEKPFTCHECGKKFSQNSHLIKHRRTHTGEQPYTCSICRRNFSRRSSLLRHQKLHL
Protein: Z-DNA binding protein 1 (A2RRL9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAQAPADPGREGHLEQRILQVLTEAGSPVKLAQLVKECQAPKRELNQVLYRMKKELKVSLTSPATWCLGGTDPEGEGPAELALSSPAKRPQQHAATIPETPGPQFSQQREEDIYRFLKDNGPQRALVIAQALGMRTAKDVNRDLYRMKSRHLLDMDEQSKAWTIYRPEDSGRRAKSASIIYQHNPINMICQNGPNSWISIANSEAIQIGHGNIITRQTVSREDGSAGPRHLPSMAPGDSSTWGTLVDPWGPQDIHMERSILRRVQLGHSNEMRLHGVPSEGPAHIPPGSPPVSATAAGPEASFEARIPSPGTHPEGEAAQRIHMKSCFLEDATIGNSNKMSISPGVAGPGGVAGSGEGEPGEDAGRRPADTQSRSHFPRDIGQPITPSHSKLTPKLETMTLGNRSHKAAEGSHYVDEASHEGSWWGGGI
Protein: Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) (Q9Y385)
Organism: Homo sapiens (Human)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12082160, ECO:0000269|PubMed:24020373, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:35831855}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12082160}.
Interaction partners:
- Protein sel-1 homolog 1
- E3 ubiquitin-protein ligase RNF5
- E3 ubiquitin-protein ligase synoviolin
- Protein OS-9
- Ubiquitin-conjugating enzyme E2 G2
- Derlin-2
- Lipid droplet-regulating VLDL assembly factor AUP1
- FAS-associated factor 2
- Ubiquitin-conjugating enzyme E2 G1
- Endoplasmic reticulum lectin 1
Sequence:
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHGRIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMPTKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDSSQADQEAKELARQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGLQNSSAASFHQPTQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQPRDNHTDHGGSAVLIVILTLALAALIFRRIYLANEYIFDFEL
Protein: Peroxiredoxin TSA1-A (EC 1.11.1.24) (Thiol-specific antioxidant protein) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin TSA1-A) (Q9Y7F0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.
Subcellular location: Cell surface {ECO:0000269|PubMed:12782322, ECO:0000269|PubMed:16102003}. Nucleus {ECO:0000269|PubMed:12782322, ECO:0000269|PubMed:16134099}. Cytoplasm {ECO:0000269|PubMed:12782322, ECO:0000269|PubMed:16134099}. Note=Localizes to the cell surface in hyphally grown cells, whereas no surface but mainly nuclear localization is found in yeast-form cells. {ECO:0000269|PubMed:12782322, ECO:0000269|PubMed:16102003}.
Interaction partners:
- Thioredoxin
- Sulfiredoxin
- Thioredoxin reductase
- Trp99p
- Trx2p
- Peroxisomal catalase
- Enolase 1
- Fructose-bisphosphate aldolase
- Phosphoglycerate kinase
Sequence:
MAPVVQQPAPSFKKTAVVDGVFEEVTLEQYKGKWVLLAFIPLAFTFVCPSEIIAYSEAVKKFAEKDAQVLFASTDSEYTWLAWTNVARKDGGIGKVDFPVLADTNHSLSRDYGVLIEEEGVALRGIFLIDPKGVLRQITINDLPVGRSVEESLRLLEAFQFTEKYGEVCPANWHPGDETIKPSPEASKEYFNKVNK
Protein: Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa) (Q7Z5G4)
Organism: Homo sapiens (Human)
Function: May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}; Lipid-anchor {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}.
Interaction partners:
- Palmitoyltransferase ZDHHC9
- Palmitoyltransferase ZDHHC5
- Golgin subfamily A member 3
- GTPase NRas
- mRNA decay activator protein ZFP36L2
- Serine palmitoyltransferase 1
- ORM1-like protein 3
- Serine palmitoyltransferase 2
- Serine palmitoyltransferase small subunit A
- Serine palmitoyltransferase small subunit B
Sequence:
MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR
Protein: Heat shock protein DnaJ with tetratricopeptide repeat-containing protein (F4K0Y5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Chaperone DnaJ-domain superfamily protein
- Chaperone DnaJ-domain superfamily protein
- AT4g39960/T5J17_130
- Chaperone DnaJ-domain superfamily protein
- Chaperone protein dnaJ C76, chloroplastic
- At3g13310
- At2g17880
- At3g17830
- NAD
- Molecular chaperone Hsp40/DnaJ family protein
Sequence:
MSKFGELNPAFSGAGRSSSNNNPDASFNSAPFPRSSSGLSKPRFSKVRRQVKSQNLKPSGTSDSLPGQSFNPFHFRGSFSGDPTPSEIGFGRSSNEGFVFGGSSHVDKLQSDEKIGIRVMEEMERLKIESEGKASRLPEDMQNLNSSFSFGVKKGSNNSVFATVELPTLLSNKLIIDSSSRSTGHVIQESMEKLNISERGTDQKQNNNVKSKVSMDYVGEKILSDDLSRKLSVGSMTTDGNHSGDSFQGSVNEKKVHDFNSSCPMNYSFVGTEPSQNLNARNVHDVSSTVNTSDFNFVSNQDSVKTGFMEFKTPNSKVNPFSSLDQKLGFNAKKDSVGATTRARRKGGKQPVKVQLNIGREFAFAESAIPNGSNEAPEAYSPMDISPYEETEVCREFSADIPPTAPNYLFDAELVAATERMEINEGDEVNNYQAEEFNTGNCADHEDLAGDSISGAETESFKSAAEEMETSSETFATASESEVTSRYKSDRKENDDHSLSNTDAASSSFTFSASSFSGVQGPLSTSKRINRKKNPIKLGQDPYILIPNATLPLKSSQHSPLTGVQSHFSTGKPSERDPLTRLHKPINNSVMEKARIEKDVSNAAQEACEKWRLRGNNAYKIGDLSRAEESYTQGIDSVPRIETSRNCLRALMLCYSNRAATRMALGRMREAIADCTMASSIDSNFLKVQVRAANCYLSLGEIEDASRYFKKCLQSGSDICVDRKIIVEASEGLQKAQRVSECMHEAGRRLQLRTLTDAEKALEILEDSLLISTYSEKLLTMKGEALLMLEKYDAAIKLCEQTVDLAGKNSPPDSHDTPKDINFRIWQCHLMLKSSFYMGKLEEAIASLEKQEQLLSATKREGNKTLESSIPLAATIRELLRLKAAGNEAFQSGRHTEAVEHYTAALACNVESRPFTAVCFCNRAAAYKALGQFSDAIADCSLAIALDQNYSKAISRRATLFEMIRDYGQAASDMERYVNILTKQMEEKTSGTLDRSTSMSNDIRQARIRLSELEEKSRKENSLDMYLVLGVVPSCSASDIRKAYRKAALKHHPDKAGQSLTRNETKDERLWKEIGEEVRKDTDKLFKMIGEAYAVLSDPAKRSQYDLEEEMHNSQKRRDGSSTSGADTDNYPFHSSRRNWREGWSSRKDPSTPRWFDPNRSNRYP
Protein: Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (Q642G4)
Organism: Rattus norvegicus (Rat)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:12488033, ECO:0000269|PubMed:30414318}; Single-pass membrane protein {ECO:0000269|PubMed:30414318}.
Interaction partners:
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal 1 receptor.
- PEX5-related protein
- Peroxisomal targeting signal 2 receptor
- Peroxisomal targeting signal 1 receptor
- Peroxisome assembly protein 12
- Peroxisomal biogenesis factor 19
- Peroxisomal ATPase PEX6
- Peroxisome biogenesis factor 10
- Peroxisome biogenesis factor 2
Sequence:
MASSEQAEQPNQPSSSPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTASDEPSPVGPATPVVPVQPPHLISQPYSPGGSRWRDYGALAIILAGIAFGFHQLYKKYLLPLILGGREDRKQLERMAASLSELSGSVAQTVTQVQTTLASVQELLRQQQQKVQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESPSSSPGKDGHSPEGSTATYRLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDEEGEEDEDDDVSHVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD