wanglab/gogpt-training-data huggingface dataset:
Protein: Myosin regulatory light polypeptide 9 (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Q9CQ19)
Organism: Mus musculus (Mouse)
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, regulates PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29799007}. Cytoplasm, cell cortex {ECO:0000269|PubMed:29799007}. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. {ECO:0000269|PubMed:29799007}.
Interaction partners:
- Myosin light chain kinase, smooth muscle
- Myosin-11
- Actin, aortic smooth muscle
- Myosin-10
- Actin, gamma-enteric smooth muscle
- Protein phosphatase 1 regulatory subunit 12A
- Myosin-9
- Myosin light polypeptide 6
- Rho-associated protein kinase 2
- Myosin light chain 6B
Sequence:
MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD
Protein: Deoxyribonuclease-2-beta (EC 3.1.22.1) (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD) (Q9QZK9)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.
Subcellular location: Lysosome {ECO:0000305}.
Interaction partners:
- Deoxyribonuclease-2-alpha
Sequence:
MTAQPLKAALPLLFVALSGVLGTPVISCINEDGKAVDWFAFYKLPRRTSRGGTGMGLDYLYLDSTMRTWSKSHHLINSSRSSLGRTLEQLYEAHNAKNDTAYLIYNDAVPASVNYSGNYGHAKGLLVWNRVQGFWLIHSIPKFPPVPEKGYEYPSSGRQYAQSGLCITLKYSQYETIDSQLLVFQPNIYSCFIPNIFRWELIHMPQMCAKSSASKIPSRRLTVLQSAQGLNFLHFAKSTFYTDDIFAAWIAQKLKVHLLVESWQRKNHELPSNCSLPYHVYNIKAIRGPLQSDFPSHHDHSKWCVSTKDSQARWTCIGDLNRSPHQALRSGGFICSKNRYIYQSFDRLVSHYASCN
Protein: Neurabin-1 (Q3UUK5)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAIIAKTRGKGRPSSPQRRMKPKEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSVHESGQNHRYSPKKEKGGGTEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSEPPGALTSGKAESADYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSKPPSNKQDTDTEDAQKSDAVPVPEVAQKGTSLASLPSEESQLSTEAEDVTTAQPEALDSTDKDSPEEPSAENQAMPKSHILSPRNEPLEDAEANVVGSERAQHQKKDLTGGDLTSPDASASSCGREVPEDSNSFESSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENNYYQPDMEYSEIVGLPEEEEIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTDGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQYDADDDETGEYATDEEEDEGGPILPSGDVAIEVFELPENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEVERKKREEVEKAHLLEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPTRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHTQSQNRAVHEWSVQQVSRWLMSLSLDQYVPEFSAQSISGEQLLQLDGNKLKALGMTSSQDRALV
Protein: Protein STRICTOSIDINE SYNTHASE-LIKE 9 (AtSSL9) (Strictosidine synthase 6) (AtSS6) (Q9M1J6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Vacuole {ECO:0000250}.
Interaction partners:
- Starch synthase 2, chloroplastic/amyloplastic
- Probable starch synthase 4, chloroplastic/amyloplastic
- Probable polygalacturonase At1g80170
- Probable pectinesterase/pectinesterase inhibitor 32
- Protein CHLORORESPIRATORY REDUCTION 7
- Pectin lyase-like superfamily protein
- Starch synthase 1, chloroplastic/amyloplastic
- Cytochrome P450 like protein
- Probable pectinesterase/pectinesterase inhibitor 16
- Protein trichome birefringence-like 38
Sequence:
MPINQKIPTWFAVPAVFAVLSVISYQTLIVPENLEGAKNVLTMAKTIPIPVAGPESIEFDPKGEGPYAAVVDGRILKWRGDDLGWVDFAYTSPHRGNCSKTEVVPTCGRPLGLTFEKKTGDLYICDGYLGLMKVGPEGGLAELIVDEAEGRKVMFANQGDIDEEEDVFYFNDSSDKYHFRDVFFVAVSGERSGRVIRYDKKTKEAKVIMDNLVCNNGLALNKDRSFLITCESGTSLVHRYWIKGPKAGTRDIFAKVPGYPDNIRLTSTGDFWIGLHCKKNLIGRLIVKYKWLGKLVEKTMKLEYVIAFINGFKPHGVAVKISGETGEVLELLEDKEGKTMKYVSEAYERDDGKLWFGSVYWPAVWVLDRK
Protein: Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (Q4QCC3)
Organism: Leishmania major
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU364099}.
Interaction partners:
- adenine phosphoribosyltransferase
- Adenylosuccinate synthetase
- Inosine-5'-monophosphate dehydrogenase
- GMP reductase
- Guanine deaminase
- GMP synthase
- Adenosine monophosphate deaminase-like protein
- AMP deaminase
- guanylate kinase
- Guanylate kinase-like protein
Sequence:
MSNSAKSPSGIVGDEGRRNYPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFKLTTGNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKKEYYEKPESKV
Protein: Protein-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H3]-lysine20 N-trimethyltransferase SMYD5) (EC 2.1.1.372) ([histone H4]-lysine36 N-trimethyltransferase SMYD5) (EC 2.1.1.359) (Q3TYX3)
Organism: Mus musculus (Mouse)
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression. In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters. Plays an important role in embryonic stem (ES) cell self-renewal and differentiation. Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks. Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6GMV2}.
Interaction partners:
- Protein-lysine N-methyltransferase SMYD4
- Histone-lysine N-methyltransferase Smyd1
Sequence:
MAASMCDVFSFCVGVADRARGSVEVRYVDSIKGKGLFATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALEKAEENAQRLTGKPSQILPHPELCSVRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPSHDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKDKDHWVRLFNHFCSRTANQEQAIVHKLLKGKFKDQLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSSLSQWVHACDALELTPQDREQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPNVTSEEEEEEDEEEGEPEDAELGDEMTDV
Protein: Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) (Q6AY80)
Organism: Rattus norvegicus (Rat)
Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAGKKVLLVYAHQEPKSFNGSMKQVAVEELSKQGCTVTVSDLYTMNFEPRATRNDVTGALSNPEVFKYGIEAYEAYKKKALTSDILEEQRKVQEADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDVPGFYDSGFLKDKLALLSFTTGGTAEMYTKAGVNGDFRYFLWPLQHGTLHFCGFKVLAPQISFGPEVSSEEQRKVMLASWVQRLKSIWKEEPIHCTPSWYFQG
Protein: WW domain-containing protein C2F3.14c (O14097)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor dre4
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor cwf26
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-processing factor 19
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-splicing factor sap61
Sequence:
MSSSKDCKATSNVDQTIPASNVNSGDFISSNTSSSNSENSNIQGKHYTQVGEDADNSFISENTPKNTFESTQTYENLESISKNEPTSEASKPLLNELVPEEPLPREPPLPNEPVPEEPLPGEPPLPDEPVPEEPLPGEPPLPNEPVPETNCHKESPLSDETVSETSKNDTSNSPTNENQAQPSIAWSEGHRIAAIWDPSQQAYYFWDTLTNTTSWNNPLEDEEQTSPLDYTAKVQFNRLSGKFMPKWASPELRSEENKAHKHMEQYFDINSSLNSHNGQSLLAERRNKRYTRKEMEQMKRRTKEKKEMKRRALYDIASDEKDFRRRKIIRY
Protein: Dynein light chain, putative (Q388R0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Dynein light chain, putative
- Dynein light chain, putative
- Dynein light chain, putative
- Dynein light chain, putative
- Dynein light chain 2B, cytoplasmic, putative
- Dynein light chain roadblock
- Dynein light chain 2B, cytoplasmic, putative
- Dynein light chain roadblock
- Dynein light chain roadblock
Sequence:
MSDETPQEGPKSPGSDTAPAPVAADDSPETVSGQEAGSSSNAEKEAMGSSAAPAAATGPPAGAQEDHDSEEEDTAAGTGSAPDAAVDINGVPANDVKNIILQVLSPCFDDEGGEDDAQRYDHIKAHGWIQHICDGIMEKLLAMRRPYKYVVHCVIMRKSGAGIHLCSSCYYGQADGWVNHAHDLSAHVYAVVSVYWSVI
Protein: Putative ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (O74523)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
Sequence:
MYKYCFRKPACISYRGIRFMSKASDTDPTLANASSAKRSAFESREKAKEDFFVHQHEIEQLRKLKESLKLHREELDELESRVDKKMKSNE
Protein: Woronin body major protein (P87252)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Major component of Woronin bodies, fungal-specific organelles that occlude septal pores in order to separate intact from damaged compartments. Hex-1 binds directly or indirectly to the Woronin body tether that in turn is anchored at the rim of the septal pore.
Subcellular location: Cell septum {ECO:0000269|PubMed:10783241, ECO:0000269|PubMed:11273682}. Note=Localizes at Woronin bodies, fungal-specific organelles that plug the septal pore in case of physical damage. {ECO:0000269|PubMed:10783241, ECO:0000269|PubMed:11273682}.
Interaction partners:
- Large ribosomal subunit protein uL18
- 60S ribosomal protein L35
- Ribosomal protein S12
- 40S ribosomal protein S3
- 40S ribosomal protein S6
- Small ribosomal subunit protein eS1
- Ribosomal protein Srp1
- Large ribosomal subunit protein eL30
- 60S ribosomal protein L25
- Large ribosomal subunit protein eL15
Sequence:
MGYYDDDAHGHVEADAAPRATTGTGTGSASQTVTIPCHHIRLGDILILQGRPCQVIRISTSAATGQHRYLGVDLFTKQLHEESSFVSNPAPSVVVQTMLGPVFKQYRVLDMQDGSIVAMTETGDVKQNLPVIDQSSLWNRLQKAFESGRGSVRVLVVSDHGREMAVDMKVVHGSRL
Protein: Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] (Q95ND5)
Organism: Sus scrofa (Pig)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P42574}.
Interaction partners:
- X-linked inhibitor of apoptosis.
- Apoptotic protease-activating factor 1
- Actin, cytoplasmic 1
- Cytochrome c
- Cytochrome c domain-containing protein
- Poly [ADP-ribose] polymerase
- Caspase-8
- Caspase-9
- Cyclin-dependent kinase inhibitor 1
- Baculoviral IAP repeat-containing protein 5
Sequence:
MENNKTSVDSKSIKTLETKILHGSKSMDSGISLDVSYKMDYPEMGLCIIINNKNFDKNTGMACRSGTDVDAANLRETFTNLKYEVRNKNDLTREEILELMHSVSKEDHSKRSSFICVLLSHGEEGKIFGTNGPVDLKKLTSFFRGDCCRTLTGKPKLFIIQACRGTELDCGIETDSGTEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAALKQYVHKLELMHILTRVNRKVAVEFESFSTDSTFHAKKQIPCIVSMLTKELYFYH
Protein: Nucleoporin Nup54 alpha-helical domain-containing protein (Q9U3B9)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nsp1_C domain-containing protein
- Nuclear Pore complex Protein
- Nuclear pore protein
- Nuclear pore complex protein 5
- Nuclear pore complex protein Nup85
- Nucleoporin NUP35
- Nuclear pore complex protein 15
- Nucleoporin_N domain-containing protein
- Protein SEC13 homolog
- Nuclear pore complex protein 14
Sequence:
MSLFGSSTPQKQAFTFPTPNAPTTSSGTLFGSTTPSKPLFGSTAQASSTPSLFGTTNTSTPSGGLFGKTGTSTTTTSTAGTLFGAAPTTSTATPSLFGASTTGLFGTSSTTSGGLGGIGSTQQTAKSPVATRLAAFKSGTLGAGSLSGNTPTSFATPSALPGTNAPQSSFLSPANNLNVAPAAYRPPYSTFGGSTPFGAASTGTAAGSTLFGSSTAKPATGGFFGSSSGSTLGGLGATQQQQQPVVQQQQVIQQYHPFVKAVGDPKLFGNDNDGVVAKLNQVAAGLGVGKAPYKDGNQLLSFSMEGNLFERFVGIGYNRISERTDDEGFVTLVLRHPITNLNTEERRDKILEIIKAILGGGPNVEVRYAPGTSMRTLSDGCTEICIIAKEGGFVAGAIKLAQILNDAPKMTQLESQLQVDKTRVLPKVGMSKAQRDRYLETVPDGIDERIWRQAIKENPAPNKLLPVPVRGWEALRDRQKAQVGESKLFHEAINALGNRVEEANHEHADAVVKMEIIRNRHKTLSYRIVRVMLAQWIVSRYSRQIDTDEDVIEAKADTLLAQMNRHNQVKFYVDKFYEILESKPDKLQESMWKMFDMTIEDEHYARRVLTKFVNICSGLYESTHQQIESLEACRRALEG
Protein: Ubiquitin-conjugating enzyme 27 (F4KAG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MIDFSRIQKELQDCERNQDSSGIRVCPKSDNLTRLTGTIPGPIGTPYEGGTFQIDITMPDGYPFEPPKMQFSTKVWHPNISSQSGAICLDILKDQWSPALTLKTALVSIQALLSAPEPKDPQDAVVAEQVLLLHHLNHLRYMKNYQVFVSTARYWTETFAKKSSLEEKVKRLVEMGFGDAQVRSAIESSGGDENLALEKLCSA
Protein: Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) (O14531)
Organism: Homo sapiens (Human)
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Dihydropyrimidinase-related protein 5
- Dihydropyrimidinase-related protein 3
- Dihydroorotate dehydrogenase
- Dihydropyrimidine dehydrogenase [NADP
- Dihydropyrimidinase-related protein 2
- Uridine 5'-monophosphate synthase
Sequence:
MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS
Protein: Uncharacterized protein C6B12.14c (O14219)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MDTNLNFSPSQSNDLSTSSGYENVLSHFKQAALSVTQLYQASTTEVLKAQKAGYNQALREVLELIESGASIDFISQYCLEKLASSDNDSSVHNHHDNSVLRNEDTQLQPHIVCNRTVRAGRPVLDEDDEEMNIATPHKRRVYDLNSSWMKRGRR
Protein: Mitochondrial Rho GTPase (EC 3.6.5.-) (F7EK49)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200, ECO:0000256|PIRNR:PIRNR037488}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200, ECO:0000256|PIRNR:PIRNR037488}.
Interaction partners:
Sequence:
MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSGNGRPLVGEGGSEANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPWGPDVNNTVCTNESGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQSLLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIVCDVVCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVVGFAMYRALLKQR
Protein: TATA box-binding protein-like 1 (TBP-like 1) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (Q5U385)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96}. Nucleus {ECO:0000250|UniProtKB:Q6SJ96}.
Interaction partners:
- Transcription initiation factor TFIID subunit
- Transcription initiation factor TFIID subunit 2
- TATA box-binding protein-like 2
- TAF7 RNA polymerase II, TATA box-binding protein
- Transcription initiation factor TFIID subunit 10
- TATA-box-binding protein
- General transcription factor IIB.
- Transcription initiation factor TFIID subunit 12
- General transcription factor IIA, 1-like
- Transcription initiation factor TFIID subunit 6
Sequence:
MEPSNDVALDIIVTNVVSVFRTRCHLNLRTIGLEGTNVIYKPEVGKVLMKLRKPRITASIWSSGKIICTGATSEEEAKLGARRLARCLQKMGFKVRFSDFKVVNVLAVCSMPFQIRLIEFTKNNRPIASYEPELHPAASYRIKNLRSTVQVFSTGNITVTGPNVQSVASAVEEIYPLLFECRKTLS
Protein: Homeobox protein Hox-C10 (Q53XI4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASLNPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADSSPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTSNFNFT
Protein: NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) (NADH dehydrogenase subunit 4) (P03910)
Organism: Bos taurus (Bovine)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17060615}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- NADH-ubiquinone oxidoreductase chain 2
- Cytochrome b
- NADH dehydrogenase 1 subunit C2
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Cytochrome c oxidase subunit 1
- NADH dehydrogenase 1 beta subcomplex subunit 3
Sequence:
MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQFGDNSLNFSLLFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLISLQLFLIMTFTAMELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAGSLPLLVALIYIQNTVGSLNFLMLQYWVQPVHNSWSNVFMWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMLRITLILNPMTDFMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVNMVITALYSLYMLIMTQRGKYTYHINNISPSFTRENALMSLHILPLLLLTLNPKIILGPLY
Protein: ARM repeat superfamily protein (F4IAF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein NPGR1
- Protein NPGR2
- Hyccin
- At5g64090
- Protein NPG1
- Phosphatidylinositol 4-kinase alpha 2
- Phosphatidylinositol 4-kinase alpha 1
Sequence:
MGVMSRRVLPACGNLCFFCPSLRARSRHPVKRYKKMLAEIFPRNQEAEPNDRKIGKLCEYASRNPLRIPKITEYLEQKCYKELRNGNIGSVKVVLCIYKKLLSSCKEQISSEIMLTFFFLVARSFTFEFLPLFSCSLLSIVRTLLEQTKEEEVQILGCNTLVDFISLQTVNSHMFNLEGLIPKLCQLAQEMGDDERSLQLRSAGMQALAFMVSFIGEHSQLSMDLDMIISVILENYMDLEKGQEDTKEVDQISDTKIPNMTKKVSFKPNPVTDYKLENMDISKSPSYWSMVCLCNIAKLAKETTTVRRVLEPLLTAFDSGDYWSPQKGVASSVLLFLQSRLEESGENCHVLVSSLIKHLDHKNVIKQQGLQINMVNVATCLALHAKQQASGAMTAVIADLIKHLRKCLQNAAESDVSVDKTKQNSDLQHALENCIAELSNKVGDAGPILDMFAVVLETISTNVVLSRTTASAILRAAHIVSVVPNVSYHKKVFPDALFHQLLLAMSHADCTTRVEAHNIFSVVLLGTLRLPWSDQHKETSEAVSGSLSVDGICTVRNQEEEKEKVEKSLNSELCKDVNHISRPSVSGQTSQQLSCQSLDSLKDLDDGIKSLCSLRLSSHQVNMLLSSLWIQATSTDNTPENFEAMASTYQITLLFSLAKRSNHMALVQCFQLAFSLRNLSLNQDGGMQHSRRRSIFTFASYMLIFGAKISNILELVPIIKESLTAQMVDPYLVLEGDIRLRAVCSGFPQEETYGSDKDDSAALNSSVIVTDDRRLKEIVITHFTSKLQTLSEEEQLNLRKEIQSDFSLDDAHSLGGQLFTDTPGPSSPLNQTELPAFEEVELSDIAAFEGISPGASGSQSGHRTSLSTNTNPVDVLSVNELLESVSETARQVASLPVSSIPVPYDQMMNQCEALVTGKQQKMSVLRSFKPQATKAITSEDNEKDEQYLLKETEEAGEDDEKAIIVADVQPQGQLGFFSQEVPQNSFRLPPSSPYDKFLKAAGC
Protein: Caspase-6 (CASP-6) (EC 3.4.22.59) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] (A0A1D5PPP7)
Organism: Gallus gallus (Chicken)
Function: Cysteine protease that plays essential roles in programmed cell death, development and innate immunity. Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein lamin-A/LMNA thereby inducing nuclear shrinkage and fragmentation. Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution. Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P55212}. Nucleus {ECO:0000250|UniProtKB:P55212}.
Interaction partners:
Sequence:
MSGAERRPAAGRVQLDSKPTPTTTADGNQNITEVDAFDKRQTFDPAVQYKMNHQRRGVALIFNHEHFFWHLRLPDRRGTLADRNNLKRSLTDLGFEVRIFDDLKAEDVLKKVFEASRDDYSNADCFVCVFLSHGENDHVYAYDAQIKIETITNMFRGDKCQSLVGKPKIFIIQACRGDKHDDPVLVQDSVDSKDETTVNQTEVDAAGVYTLPAGADFIMCYSVAQGYFSHRETVNGSWYIQDLCEALGKHGSSLEFTELLTVVNRKVSHRKVDICRDINAIGKKQIPCFASMLTKKLYFHPKSK