wanglab/gogpt-training-data huggingface dataset:
Protein: Paired box protein Pax-6 (A0A1W2PS91)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNQNVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
Protein: Unc-112-related protein (Fermitin-1) (Q9VZI3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably involved in cell adhesion.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Integrin linked kinase, isoform A
- Zyx102 protein
- GH23568p
- Integrin beta-PS
- Vinculin
- LIM domain-containing protein
- Paxillin, isoform F
- Rhea, isoform B
- Integrin beta-nu
Sequence:
MIHVGENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDPELPKDWSDHALWWPAKNIWLTRTRSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCKPLEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAVQRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDENIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGGWS
Protein: Antitoxin RelB (P0C079)
Organism: Escherichia coli (strain K12)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction, preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequences; DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity. Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon.
Interaction partners:
- mRNA interferase toxin RelE
- Endoribonuclease toxin MazF
- mRNA interferase toxin MqsR
- Antitoxin YefM
- Antitoxin DinJ
- Toxin YoeB
- Antitoxin MazE
- mRNA interferase toxin YafQ
- Antitoxin MqsA
- Antitoxin HigA
Sequence:
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Protein: LD31046p (LD40351p) (Shal K[+] channel interacting protein, isoform B) (Q8SZS0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAVSNIVCEWLRALGLAQYAESFLDNGYDDLEICKQVGDPDLDAIGVENPAHRHKLLKSIRSLREKGAASVYFMLNDPNSLSGSMEILCETPPNNELELVLREQLETDGVRLTAHPYSTPPSSCLSDKEEDEIYGFGYGVFAPRVARGGLTQQQQLLQQQTLQTQQSIQQQQQQMQQQQQQLPIVPGQQQQGPHQHQTLPPNVAHLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSFEETIHRLKVQEAMRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNGGGGGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRVRFSNNRESTGVISLRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTSMASCICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESNSLDDVVTKCSSEIMKRVESARRCKDNPFKTTLPGGGRLGKKSFLGGNGLMADDTLTRGGLSEKSSDSGVSSSSLSSGPLKSST
Protein: Protein-glutamate methylesterase/protein-glutamine glutaminase (EC 3.1.1.61) (EC 3.5.1.44) (Chemotaxis response regulator protein-glutamate methylesterase/glutamine deamidase) (Methyl-accepting chemotaxis proteins-specific methylesterase/deamidase) (MCP-specific methylesterase/deamidase) (P07330)
Organism: Escherichia coli (strain K12)
Function: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Catalyzes its own deactivation by removing the activating phosphoryl group.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00099, ECO:0000269|PubMed:358191}.
Interaction partners:
- Chemotaxis protein CheA
- Chemotaxis protein CheW
- Methyl-accepting chemotaxis protein IV
- Chemotaxis protein CheY
- Chemotaxis protein methyltransferase
- Methyl-accepting chemotaxis protein II
- Protein phosphatase CheZ
- Methyl-accepting chemotaxis protein I
- Aerotaxis receptor
- Flagellar motor switch protein FliM
Sequence:
MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYNEMIAEKVRTAAKASLAAHKPLSAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPLSSPALLITQHMPPGFTRSFADRLNKLCQIGVKEAEDGERVLPGHAYIAPGDRHMELSRSGANYQIKIHDGPAVNRHRPSVDVLFHSVAKQAGRNAVGVILTGMGNDGAAGMLAMRQAGAWTLAQNEASCVVFGMPREAINMGGVCEVVDLSQVSQQMLAKISAGQAIRI
Protein: CCR4-NOT transcription complex subunit 3a (CCR4-NOT transcription complex, subunit 3a) (F1Q4L8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 7
- poly
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 4
- CCR4-NOT transcription complex, subunit 4b.
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 10
Sequence:
MADKRKLQGEIDRCLKKVAEGVEQFEDIWKKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLVENRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEETEQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKEKQDRIEELKRLIERHRYHIRMLETILRMLDNDSIQVDAIHKIKDDVEYYIDSSQDPDFEENEFLYDDLDLEDIPATLMATSPQGHIEDEMFLQSSSTPTSTTSSSPIPPSPATGTTEILEDKRGRSTDSEVSQSPVKNGNPSLSSFSSSASSGSSSSSSSLVSMATVVGGCTAVSGGSSLLASFSSAVQQHPPQSQQQTQVKLSSTSIPSNNTPSPPSHPTLPASTASSLPSSSTPGPITSNSLSQASSVPGVESSRLGLGKGGVTVTSSSSVSQMPGLGLTSLSSSLNTMAGLLSGSTPAPYAQAAAGGTTGGASSGPVGSGSSSAGISIPSGVVGGANTGATSNGTGTGASIGLLGSSPGHGTLTGGILNLVQGQSALQGSTQVPVSPVGTAPGGGTGESGLGGNGSSSGVSGGVGTNVAPARPPSGLKQNGATSESFLSLGYSAVVADNTPDSSLSSASQSQNSHSSSSSSSTNQTLDNGPSLLSSITLPPSTPSPAFTDSTPGGGSLLNGPHSYTPNTEAIKAPEPPSSLKAMAERAALGLALDGEIPSLHLTDRDSLELFSGSSAPPGPTTAPQPAVSEVSLPPSLGACPLGPTPLTKEQLYQQAMQEAAWTHMPHPSDSERIRQYLMRNPCPTPPFHHQMPPHHSDSIEFYQRLSTETLFFIFYYLEGTKAQYLSAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ
Protein: ELAV-like RNA-binding protein 1b (ELAV-like protein 1 isoform X2) (ELAV-like protein 1b isoform e) (A0A0R4IWC9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTQKNVEDMFTQYGRIINSRILVDQASGLSRGVAFIRFDKRSEAEEAIKDLNGSKPSGASEPITVKFAANPNQSKNSQLLSQLYHTQSRRFGGPVHHQPQRFRFSPMSVDHSVSSMNVASSSSSGWCIFVYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTSKCKGFGFVTMTNYEEAAMAISSLNGYRLGDKVLQVSFKSSKSHK
Protein: Neuroplastin a (Sb:cb578) (Zgc:162565 protein) (A4IGC1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Neural cell adhesion molecule 1 isoform X1
- Cerebral dopamine neurotrophic factor
- Leucine-rich repeat-containing 17
- Mesencephalic astrocyte-derived neurotrophic factor.
Sequence:
MSFAGNPLVILVGVLMLHSGSAQNEPSIDSSEHMILTMGSSSSITLQCNLTASQSSHRESFWMKNGEEIMDTRDKTKNTEYKLTKPKADDAGEYMCVYTFDSAPQANATIEIKAGPEITTHKHSENKNEGERAILFCKSVGYPYPQWSWRKIDNGASMEMMDNSSGRFFIISKDGYTELSIINLDINSDPGEYECNATNFISSTSKKWILRVRSHLAPLWPLLGVLAEIIILVLIIVIYEKRKKPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN
Protein: Chromatin assembly factor 1 subunit B (Chromatin assembly factor 1, subunit B) (E7EYR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Chromatin assembly factor 1 subunit A
- Histone-binding protein RBBP4
- Histone chaperone asf1b-A
- Histone chaperone asf1b-B
- Proliferating cell nuclear antigen
- Histone-binding protein RBBP7
- Integrator complex assembly factor WDR73
- Insulin-induced gene 1 protein
- Insulin-induced gene protein
- CDC45 cell division cycle 45 homolog
Sequence:
MKVVTCEIAWHNKEPVYSLDFQQSGDGKTQRLATAGVDTTVRMWRVDKGPDGKAVVEFLSNLARHTKAVNVVRFSPTAEVLASGGDDAAILLWKLNDNKEPEQTPTFQEEEDAQLNKESWSVVKTLRGHIEDVYDISWTSDGNFMASGSVDNTAIMWDVNKGQKMCIFNDHKSYVQGVAWDPLGQYISTLSCDRVMRVYSAHNRKKAYSISKMTSSATADGEVKNYRMFHDDSMRSFFRRLTFTPDGSFLLAPAGCVEAGENVTNTTYVFSRKSFKRPIAHLPCPSKATLAVRCSPVYFELRTKRAEDDSLKPVANTFNLPYRLVFAVASEDSIFFYDTQQTLPFGYVSNIHYHTLSDLSWSRDGSFLAVSSTDGYCSFISFDEGELGTPLKEKPPLEMVTPSSTNEKKGKRALANGRTASPVPRQANTPAAQDKEKEGSAGPASSKTSSVSGTEEKRTPQALKTKAQPRRITLNTLEGWGKPSTPKSPAAASSTAPSTPKSAPSTPGSSRAPLTPHTAPSTPLGPLNSKNGTTPKGPTPRRISLTPVVSKSPAAFVPPSSTEKAKHERPSPSSDPACKPPESKRSKTDVPDGSVQSSKNKEATEITVKPKEP
Protein: At3g15680 (Ran BP2/NZF zinc finger-like superfamily protein) (Zinc finger protein-like Ser/Thr protein kinase-like protein) (Q9LW11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RanBP2-type zinc finger protein At1g67325
- Cysteine/Histidine-rich C1 domain family protein
- RNA-binding protein-like protein
- Zinc ion binding protein
- At3g13230
- Zinc finger
- At2g45350/F14N22.7
- Uncharacterized protein
- At1g11800/F25C20_3
- ALC-interacting protein 1
Sequence:
MSRPGDWNCRSCSHLNFQRRDSCQRCGDSRSGPGGVGGLDFGNFGGRAMSAFGFTTGSDVRPGDWYCTVGNCGTHNFASRSTCFKCGTFKDETGAGGGGGGIGGPAMFDADIMRSRVPGNGGRSSWKSGDWICTRIGCNEHNFASRMECFRCNAPRDFSNRTSF
Protein: Cyclomaltodextrinase (CDase) (CDase I-5) (EC 3.2.1.135) (EC 3.2.1.54) (Cyclomaltodextrin hydrolase, decycling) (Q59226)
Organism: Bacillus sp
Function: Hydrolyzes alpha-, beta- and gamma-cyclodextrins and the resulting linear maltodextrins, with the highest activity with beta-cyclodextrin (cyclomaltoheptaose). Soluble starch is hydrolyzed slowly, but it is nevertheless preferred over pullulan as a substrate. Is able to hydrolyze amylose and amylopectin, with a very strong preference for amylose, with maltose and glucose as the main products. Maltose and glucose are the main hydrolysis products of cyclomaltodextrins, maltodextrins and starch, whereas panose is the main hydrolysis product of pullulan. Acarbose is partially hydrolyzed to glucose and pseudotrisaccharide. No activity with maltose as substrate. Has transglycosylating activity with high concentrations of maltotriose, maltotetraose and starch.
Interaction partners:
Sequence:
MFLEAVYHRPRKNWSYAYNGTTVHLRIRTKKDDMTAVYALAGDKYMWDHTMEYVPMTKLATDELFDYWECEVTPPYRRVKYGFLLQQGHEKRWMTEYDFLTEPPRNPDRLFEYPFINPVDVFQPPAWVKDAIFYQIFPERFANGDTRNDPEGTLPWGSADPTPSCFFGGDLQGVIDHLDHLSKLGVNAVYFTPLFKATTNHKYDTEDYFQIDPQFGDKDTLKKLVDLCHERGIRVLLDAVFNHSGRTFPPFVDVLKNGEKSKYKDWFHIRSLPLEVVDGIPTYDTFAFEPLMPKLNTEHPDVKEYLLKAAEYWIRETGIDGWRLDVANEVSHQFWREFRRVVKQANPDAYILGEVWHESSIWLEGDQFDAVMNYPFTNAVLDFFIHQIADAEKFSFMLGKQLAGYPRQASEVMFNLLDSHDTARLLTQADGDKRKMKLAVLFQFTYFGTPCIYYGDEVGLDGGHDPGCRKCMEWDETKHDKDLFAFYQTVIRLRQAHAALRTGTFKFLTAEKNSRQIAYLREDDQDTILVVMNNDKAGHTLRCLSGMHSGPICGTTMS
Protein: N-terminal autoprotease (A0N0F0)
Organism: Bovine viral diarrhea virus (BVDV) (Mucosal disease virus)
Interaction partners:
Sequence:
MELITNELLYKTYKQKPVGVEEPVYDRTGNPLFGERGPIHPQSTLKLPHKRGKNEIPTNLASLPKRGDCRSGNSRGSVSGIYVKPGPLFYQDYIGPVYHRAPLEFFEEGSMCVTTKRIGRTTGSDGKLYHIYVCIDGCILVKSATRCHQKVLRWVHNKLNCPLWVTSC
Protein: Neutral amino acid uniporter 4 (Solute carrier family 36 member 4) (Q8CH36)
Organism: Mus musculus (Mouse)
Function: Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine. The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:24530433}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ras-related protein Rab-1A
Sequence:
MEAPAPAETAGCEELDMDVMRPLINEQNFDGSSDEEQEQTLVPIQKHYQLDGQHGISFLQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKSTLGYSDTVSFAMEASPWSCLQRQAAWGRQVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIVSNGSDLSHACERRSVDLRVYMLCFLPLIILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRFPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGVTARLHAKWKRICEFGIRSLLVSITRAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKDHYNIWMILKNISIAFTGVVGFLLGTYVTVEEIIYPTTAVVAGTSQSPFLNVNSTCITSGL
Protein: Mitogen-activated protein kinase 11 (AtMPK11) (MAP kinase 11) (EC 2.7.11.24) (Q9LMM5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitogen-activated protein kinase kinase 6
- Mitogen-activated protein kinase kinase 1
- Probable protein phosphatase 2C 22
- Protein-tyrosine-phosphatase PTP1
- Uncharacterized protein At4g14450
- Probable WRKY transcription factor 33
- Probable calcium-binding protein CML47
- At1g25400
- Mitogen-activated protein kinase kinase 2
- At3g23170
Sequence:
MSIEKPFFGDDSNRGVSINGGRYVQYNVYGNLFEVSKKYVPPLRPIGRGASGIVCAAWNSETGEEVAIKKIGNAFGNIIDAKRTLREIKLLKHMDHDNVIAIIDIIRPPQPDNFNDVHIVYELMDTDLHHIIRSNQPLTDDHSRFFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKIGDFGLARTKSETDFMTEYVVTRWYRAPELLLNCSEYTAAIDIWSVGCILGEIMTREPLFPGRDYVQQLRLITELIGSPDDSSLGFLRSDNARRYVRQLPQYPRQNFAARFPNMSVNAVDLLQKMLVFDPNRRITVDEALCHPYLAPLHEYNEEPVCVRPFHFDFEQPSLTEENIKELIYRESVKFNP
Protein: BTB/POZ domain-containing protein KCTD1 (Potassium channel tetramerization domain-containing protein 1) (Q719H9)
Organism: Homo sapiens (Human)
Function: May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.
Subcellular location: Nucleus {ECO:0000269|PubMed:18358072, ECO:0000269|PubMed:38113115}.
Interaction partners:
- Transcription factor AP-2-alpha
- Transcription factor AP-2 gamma
- Transcription factor AP-2-beta
- SUMO-conjugating enzyme UBC9
- BTB/POZ domain-containing protein KCTD2
Sequence:
MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVPSVIRIKQEPLD
Protein: Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (A0A1L8FDW4)
Organism: Xenopus laevis (African clawed frog)
Function: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the pex13-pex14 docking complex along with cargo proteins. Pex5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:35931083}. Peroxisome matrix {ECO:0000269|PubMed:35931083}. Note=Cycles between the cytosol and the peroxisome matrix (PubMed:35931083). Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of pex13 and pex14, leading to translocation into the peroxisome matrix along with cargo proteins (PubMed:35931083). Export and recycling to the cytosol is initiated by binding to the pex2-pex10-pex12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol (PubMed:35931083). Cys-11 of pex5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the pex1-pex6 AAA ATPase complex (PubMed:35931083). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix (PubMed:35931083). The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzymes, resetting pex5 for a subsequent import cycle (PubMed:35931083). {ECO:0000269|PubMed:35931083}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Pex14_N domain-containing protein.
- Sterol carrier protein 2
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 10-A
- Peroxisome assembly protein 10-B
- Aminotran_5 domain-containing protein.
- Alanine--glyoxylate aminotransferase
- Peroxisomal biogenesis factor 19
- Peroxisome biogenesis factor 2
Sequence:
MAMRGLIEAECGGSNPLMKLTNHFTQDKALREEGLQHVSWPPGATVVSKPLGEATEDELVSEFLHTRAPSLQSRAPHTFKMDGLLAEMQEIEQSSFRPEPLRAPGVADLALSEQWSAEFLGVEVDPVEEEDWSREFTEQADPHASPSRWAEEYLQQSEEKLWLGESEGAMAEKWTEEYQPEDDLQREAKSLVSQVTDPKLANTQFLQFVKRIGDGELSFSHAPSTPSQTVSQAEQWSEQFVHEQAEQWVDQFAPLEKDFEKAKAAVESDVDFWDKLQEEWEEMAKRDAEAHPWLSDFQDLSSKSIDKGYMFEDNNPFSEVSLPFEEGLKHLREGDLPSAVRLFEVAVKRDPQHMEAWQYLGTTQAENEQELAAISALRRCIDLKPDNLSALMALAVSYTNECLQQQACHTLREWLRHNPKYSHLVKEESSSNASRARSFGTLLSDSVFSDVRELFLSAVNSDPSQVDPDVQCGLGVLFNLSGEYQKAVDCFTAALGQRPDDYLLWNKLGATLANGNDSEAAVEAYRRALQLQPGFIRSRYNLGIACINLGAHREAIEHFLEALSMQQQSGGCESAMSDNIWSTLRMALSMIGQSDLYSSADARDLATLQAAFPPHSAAQ
Protein: Cytochrome b6 (P31480)
Organism: Euglena gracilis
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00633}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00633}.
Interaction partners:
Sequence:
MSRVYDWFEERLEIQAIADDVSSKYVPPHVNIFYCLGGITFTCFIIQVATGFAMTFYYRPTVTEAFLSVKYIMNEVNFGWLIRSIHRWSASMMVLMMILHVCRVYLTGGFKKPRELTWVTGIILAILTVSFGVTGYSLPWDQVGYWAVKIVTGVPEAIPLIGNFIVELLRGSVSVGQSTLTRFYSLHTFVLPLLTATFMLGHFLMIRKQGISGPL
Protein: Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) (P24668)
Organism: Mus musculus (Mouse)
Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subcellular location: Lysosome membrane; Single-pass type I membrane protein.
Interaction partners:
- Cation-independent mannose-6-phosphate receptor
- ADP-ribosylation factor-binding protein GGA3
- ADP-ribosylation factor-binding protein GGA1
- AP-1 complex subunit gamma-1
- Perilipin-3
- Vesicle transport through interaction with t-SNAREs homolog 1A
- GRIP and coiled-coil domain-containing protein 2
Sequence:
MFPFSGCWRTELLLLLLLAVAVRESWQIEEKSCDLVGEKDKESKNEVALLERLRPLFNKSFESTVGQGSDTYSYIFRVCREASNHSSGAGLVQINKSNDKETVVGRINETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLAANFNPVSEERGKVQDCFYLFEMDSSLACSPEVSHLSVGSILLVIFASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Protein: WW domain-containing protein ZK1098.1 (P34600)
Organism: Caenorhabditis elegans
Interaction partners:
- U1 small nuclear ribonucleoprotein 70 kDa
- LUC7-related splicing factor homolog
- U1 small nuclear ribonucleoprotein C
- Splicing factor U2AF 65 kDa subunit
- RRM domain-containing protein
- Cell division cycle 5-like protein
- Probable small nuclear ribonucleoprotein F
- Suppressor of forked domain-containing protein
- Probable small nuclear ribonucleoprotein G
- Probable small nuclear ribonucleoprotein Sm D1
Sequence:
MLPNGFSFLNPNLVAAANIQQVLLNQRFGMPPVGSIAQVPLLQMPTHSVVAPHVAAPTRPSPMLVPPGMGIDESHSSPSVESDWSVHTNEKGTPYYHNRVTKQTSWIKPDVLKTPLERSTSGQPQQGQWKEFMSDDGKPYYYNTLTKKTQWVKPDGEEITKGEQKPAAKAATVDTVALAAAVQQKKAESDLDKAMKATLASMPNVPLPSEKKEEESVNDEVELKKRQSERFRELLRDKYNDGKITTNCNWDQAVKWIQNDPRFRILNKVSEKKQLFNAWKVQRGKEERDEKRLAIKKSKEDLEKFLQEHPKMKESLKYQKASDIFSKEPLWIAVNDEDRKEIFRDCIDFVARRDKEKKEEDRKRDIAAFSHVLQSMEQITYKTTWAQAQRILYENPQFAERKDLHFMDKEDALTVFEDHIKQAEKEHDEEKEQEEKRLRRQQRKVREEYRLLLESLHKRGELTSMSLWTSLFPIISTDTRFELMLFQPGSSPLDLFKFFVEDLKEQYTEDRRLIKEILTEKGCQVIATTEYREFSDWVVSHEKGGKVDHGNMKLCYNSLIEKAESKAKDEEKESLRRKRRLESEFRNLLKEHNVDKDSEWTVIKPKIEKDKAYLAMENDDERETAFNHYKNGTSGTTAGSEILEKKKKKKDKKKKNKRSDNNSESEGEIREKEKKKKKKHSKEDRMDDEERGKKSKKSRKRSPSRSESPRHSSEKRKRRESEAD
Protein: Protein ImuA (Q9A3J1)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: Along with DnaE2 and ImuB is required for the error-prone processing of DNA lesions.
Interaction partners:
- Protein ImuB
- Error-prone DNA polymerase
- DNA polymerase IV
- DNA polymerase III subunit alpha
- LexA repressor
- Protein RecA
Sequence:
MEAGTRTPTPVLSFGEPSIDGCFPGGGLPLGGWHEVTGAGLEDETGAAPAAFVTQLIRGLTDRKGGAVVWVARRADLFAPGLLGLGFPAARLIQVRARDEAETLSLLEDALSTQGVAAAVAEAEAPDLTAGRRLQLACEKRGGFGVVLHRRPYGGRAGGKPRLVSGSASFSRWRIAPAPSGPPPDDIGLGPPRWRVELERCRGGRPGGWILQAQEAGHGPHPFRLVSQLADHDVAAAEAGRRFG
Protein: Nodulin-like domain-containing protein (Q57VL5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Generative cell specific-1/HAP2 domain-containing protein
Sequence:
MSAPVDNVVVERLSTANQKPVSEPRRFLMLVIGVSCSMCTSFMYAFNLISGAMQERYDLTQRDLSTITTVGICVGYFMLPYGFIYDYLGPRPVFVISMTVFCLGTLLLALTFQEVIEGSVVRLSVYNALMMLGCTLFDLGALVTVLSVFPSNRGIVVATMKTTTGLGSAILGSIRLAFFSGNTSAYFYFLMSWALAAGILALTFVRLPPFHLTGYQEKHLDEEEKAQLRMTKTVYLKQKAPMWRFVHGFAILVTLIVFLPLQGSLVAYLKLGSNFKVGFALVVIALIVIFPFMAFPLTTFDGKRPHDDSDSKAKEHVGAGDEISAAEDKVVETDVDYIAPQFQETFIAGLKTARLWCLLWSAFCCLGANYVIIYNARFFYTALAGEAPEDALNTLLTVLNGAGSAVGRLCMGYFEIWSQKRPAADRIPITAALYVPSVCIITMLTLFLTLPKAALPLPYFIVAFSNGFTAATMALVTRTIFAKDPAKHYNFCFIGSIMSAIFLNRLLYGEWYTQQADKLGQDVCTERVCVVMPLAFMLGLAFLGFLTTTYLHLQYRRLCKLALEERQRIREEERVLNELPSNPTEPTGNAGEPVHQLK
Protein: Putative mitotic B-type cyclin CycB2 (Q8I8A8)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MNPTALREVSNLSTGSGDVKQRLAQRRSANLESCRYPYSSSAVRHGSDSLLSLRSSLYSPVGTAGKESSVSPHADRLRENNPVYCSDVIKDITTMYMESEKEAIYGQVLPSPRYLTYQPEINEKMRMILVDWLIDVHLKFKLHPETLYLTVSIVDRYLSSVNTRRTTGRYIPRSKLQLVGITAILLAAKYEEIWPPEVKECVYICANTYTRDEVIRMEREMCTELSFRFTVPTPFPFIVRLLDVVEGLERQQQTQQLSHQLQQIQSQSQSQSQQTQMQASQSQPQSLSRSRSQSRSQPRSDEECTAYVVQLRHTAFFFLDHGMLDYKCLQFSPSQQAKAALFLALVTLHMKEQGSSYVLNNDIIWTRQLQYYSKAQVRDFKACARTMLDFVSYVSTTRYQSVRRKYSSSKYGEVAKLTMPSEVPDF
Protein: CDKN1A interacting zinc finger protein 1 (F7D5G9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPNRKTVPLEDREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKT
Protein: Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) (Q7Z6B0)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes.
Subcellular location: Membrane {ECO:0000269|PubMed:12808037}; Peripheral membrane protein {ECO:0000269|PubMed:12808037}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12808037}; Peripheral membrane protein {ECO:0000269|PubMed:12808037}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17596511}. Note=Colocalizes with GGA1, GGA2 and GGA3. {ECO:0000269|PubMed:12808037, ECO:0000269|PubMed:17596511}.
Interaction partners:
- ADP-ribosylation factor-binding protein GGA1
Sequence:
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSALIATEPVDIE