wanglab/gogpt-training-data huggingface dataset:
Protein: ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) (Q9NP61)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17760859}. Golgi apparatus membrane {ECO:0000269|PubMed:17760859}; Peripheral membrane protein {ECO:0000269|PubMed:17760859}; Cytoplasmic side {ECO:0000269|PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Interaction partners:
- Coatomer subunit beta
- ADP-ribosylation factor 1
- Coatomer subunit beta'
- Coatomer subunit alpha
- ADP-ribosylation factor GTPase-activating protein 1
- Coatomer subunit delta
- Coatomer subunit gamma-1
- Coatomer subunit gamma-2
- ADP-ribosylation factor 4
- ADP-ribosylation factor GTPase-activating protein 2
Sequence:
MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSLASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLPNAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS
Protein: Response regulator 2 (ZmRR2 protein) (Q9S7U8)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MAAAATATPSVAPESGDRKAVAPPVDAVDLELELEEKHVLAVDDSSVDRAVIAKILRSSKYRVTTVDSATRALELLALGLVPDVNMIITDYWMPGMTGYELLKHVKESSALRAIPVVIMSSENVPTRISRCLEEGAEDFLLKPVRPADVSRLCSRIR
Protein: Uncharacterized protein (Q3TC43)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGSEHPGSKACGLSGARMTT
Protein: ATP synthase subunit beta (EC 7.1.2.2) (V9HW31)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHSS
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (A9JRD0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 2
- BTB
- Protein tyrosine phosphatase receptor type D.
- Protein tyrosine phosphatase receptor type Db
- Mitogen-activated protein kinase kinase kinase 3.
- Zinc finger protein 609a
- TOX high mobility group box family member 3
- SKI family transcriptional corepressor 1 homolog-B
- lysoplasmalogenase
- Mitogen-activated protein kinase kinase kinase 4
Sequence:
MLLLVLSNLSNMESEGIVIRIKTPVGDMDSPVDSPSHLNFNDLLAAIRDAMPEATVTAFEYEDEVGDRITVRSDDELKAMLSYYCNTVMEQRFNGLLPEPLQIFPRAGKTPGIRNIHGLKVNTRPESSSGRSSSAADSRSSDSSLKKSSAELKKILTNGQINEHDLQYQEQLGHGNGGTVYKAYHLLGKRIVAVKVIPLDITVELQKQIMSELEILYKCDSPYIIKFYSAFFVENRISICTEFMDGGSLDVYWRIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSVGISFMELALGSFPYPQIQKNQGSLMPLQLLQCIVDEDPPVLPVGQFSEKFVHFITQCMRKLPKERPAPNNLMDHPFIVQYNDGNTEVVSMWVCRSLEDRKAQQPQRLM
Protein: Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) (P18841)
Organism: Mesocricetus auratus (Golden hamster)
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
Subcellular location: Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P35368}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P35368}. Membrane, caveola {ECO:0000250|UniProtKB:P35368}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-12
- Alpha-1A adrenergic receptor
- Guanine nucleotide-binding protein subunit alpha
- Alpha-1D adrenergic receptor
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
- Endothelin-1
- Endothelin-3
Sequence:
MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
Protein: Sulfotransferase (EC 2.8.2.-) (Q29RB5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Antithrombin-III
- D-glucuronyl C5-epimerase B
Sequence:
MLWTLLLALVLLLLLQAQLLVCLHELQDTLDLVTSATPSGPSNASTLQRLPGAIIIGVRKGGTRALLEMLNLHPDVEVAKTEIHYFNLDENFRKGLDWYRSQMPITLPGQLTVEKTPGYFTAPPAPRRIWAMNPAVKLLLIIRDPAERLVSDYTQVLHNRIQQNKPYQSLEELLLSQGHINPKYKALQRSFYYQHLARWLELFPREQIHIVDGEALIRNPFPELQKAETFLELPPQIKPDNFYFNVTKGFYCMLSAGHDKCLDESKGRPHAPLSNEAFQKLCRYLRVPNQIFFRMVGQRFDWC
Protein: E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2) (P90489)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Membrane-bound E3 ubiquitin ligase expressed at the immediate early stage of viral reactivation to mediate polyubiquitination of various host membrane proteins related to the immune response. Promotes ubiquitination and subsequent degradation of host MHC-I, CD86, DC-SIGN and DC-SIGNR, ICAM1 and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Alters monocyte metabolism and proliferation by mediating rapid internalization of cellular growth factor-binding receptor tyrosine kinases from the surface leading to increased signaling.
Subcellular location: Host cell membrane {ECO:0000269|PubMed:10684303}; Multi-pass membrane protein {ECO:0000269|PubMed:10684303}. Host endoplasmic reticulum {ECO:0000269|PubMed:10684303}. Note=Probably exerts its effects at the plasma membrane during viral infection.
Interaction partners:
Sequence:
MASKDVEEGVEGPICWICREEVGNEGIHPCACTGELDVVHPQCLSTWLTVSRNTACQMCRVIYRTRTQWRSRLNLWPEMERQEIFELFLLMSVVVAGLVGVALCTWTLLVILTAPAGTFSPGAVLGFLCFFGFYQIFIVFAFGGICRVSGTVRALYAANNTRVTVLPYRRPRRPTANEDNIELTVLVGPAGGTDEEPTDESSEGDVASGDKERDGSSGDEPDGGPNDRAGLRGTARTDLCAPTKKPVRKNHPKNNG
Protein: Uncharacterized protein (Q20756)
Organism: Caenorhabditis elegans
Interaction partners:
- Peptidase M20 dimerisation domain-containing protein
- Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein
- Surfeit locus protein 4 homolog
Sequence:
MNQKLAFIVCFILSTVLAIHTIRDLNGVIVENDNDICDGMCHSNYSDIIKECQYGCNHRSGIRERLNPFQSCLGACEARFRVNYAERGNDTEFINRAWEACLHACRLPYKTKIRWNVYIDLRSGEPIWNFERIISDGHRISSEALEYDDLISTVALRKSHFFMDPSSKLRFPNLNVYETDSRAMQLIMMEMLKKVRQEITSMAPRRFDGVSSIDYIGPRLVENGPNGPVIKDITELEYRPKDVLFYKGMVFKIEDLFDNYEEYQDHRTMFMYFSLIVLGFVMICGCFKLRNHYAATEAARLRRVTHQDGSDDWTKRIPTTGEAPPYYSPPERKKLFDLLKE
Protein: Glycine-rich domain-containing protein 2 (AtGRDP2) (Q9SZJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in development and stress responses, probably through an auxin-dependent mechanism.
Interaction partners:
- Tapetal oleosin GRP-17
- Glycine-rich protein 20
- Polyadenylate-binding protein 2
- Polyadenylate-binding protein 3
- Glycine-rich RNA-binding protein RZ1B
- ATA20 protein
- Glycine-rich protein 5
- Heparanase-like protein 2
- 3-ketoacyl-CoA synthase 15
Sequence:
MDKEKEQTLEWNEAQKIDISVDLLAAAKKHLLFLGAVDRNRCLYDGPALQRAIYRYNAYWLPLLAQYTESSSICQGPLVPPLDCEWVWHCHRLNPVRYKTDCEQFYGRVLDNSGVVSSVNGNCKSQTETLWKRLYPTEPYDLDFANAISEPADVSALEKCTTYDLVLAVKRQSPFFYQVSRAHVDNDVFLQEAVARYKAFLYLIKGNRERSIKLFCVPTYDIDLIWHTHQLHAISYCNDLTKMIGKVLEHDDTDSDRSKGKKLDTGFSGTTAQWEETFGRRYWKAGAMNRGNTPKPVTTSPYVCSGKKSIAKEEESQNVIQYPEVKVIEVILEIVGVKNLPDAHKGKVFVLFSKTQPDSLFNAERRLTVLSESCGEKQVALFQCEPTGELSFQLMSSKSKSLGFTSLSFSEFLSPVTKLSVEKWLELTPTKRGKADDPNPISLRVAVSFTPPTRSPTVLHLVQARPSLKGSCFLPMLRKVRLAKSFTRVVDETETEVINLQMRNSNDAAPKGDRRQVIGVKECGETYVLAEYDGTFWSLLDSKWSLKQTCNPATDGPLFELSGTRMVKVYSGRKLEYEPKHCSKLRSEQDFMTAVEFSKQHPYGKAVGLLDLKFGSIEANEKWLVLPGMVSSFILSDLLKKEGFSAAAKDTVKANGITEESTEIDVLSQEKLEEETMMDVDTTTPVAVAAEKINGGARCFSKELSGNMIEEEGGHCGGCGGCGGCGGGGGCGGGGRCGGMTKIEGCGGGSCTGGSTGCGNCGGGCGNMMKNNANGNAPSVENDAVTA
Protein: Degradation in the endoplasmic reticulum protein 1 (P38307)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Specifically required for the ERAD-L pathway which mediates the degradation of proteins with misfolded lumenal domains within the endoplasmic reticulum (ER). Facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with HRD1. Both proteins have lateral gates facing each other and distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer. Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8631297}; Multi-pass membrane protein {ECO:0000269|PubMed:8631297}.
Interaction partners:
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- Ubiquitin fusion degradation protein 1
- Cell division control protein 48
- Protein OS-9 homolog
- Nuclear protein localization protein 4
- ERAD-associated E3 ubiquitin-protein ligase component HRD3
- UBX domain-containing protein 2
- U1 SNP1-associating protein 1
- DER1-like family member protein 1
- ER-derived vesicles protein ERV41
Sequence:
MDAVILNLLGDIPLVTRLWTIGCLVLSGLTSLRIVDPGKVVYSYDLVFKKGQYGRLLYSIFDYGAFNWISMINIFVSANHLSTLENSFNLRRKFCWIIFLLLVILVKMTSIEQPAASLGVLLHENLVYYELKKNGNQMNVRFFGAIDVSPSIFPIYMNAVMYFVYKRSWLEIAMNFMPGHVIYYMDDIIGKIYGIDLCKSPYDWFRNTETP
Protein: Gamma-secretase subunit APH-1 (APH-1) (F7EYZ3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
Interaction partners:
Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFVTAGGSLRSIQRSLSCKD
Protein: Esculentin-2ISa (F1T151)
Organism: Odorrana ishikawae (Ishikawa's frog) (Rana ishikawae)
Function: Has antimicrobial activity against Gram-negative bacterium E.coli ATCC 8739 (MIC=12.5 ug), against Gram positive bacteria S.aureus ATCC 6538 (MIC=3.1 ug), methicillin-resistant S.aureus ATCC 43300 (MIC=25 ug), B.subtilis ATCC 6633 (MIC=6.3 ug) and against fungus C.albicans ATCC 90028 (MIC=100 ug).
Subcellular location: Secreted {ECO:0000305|PubMed:21193000}.
Interaction partners:
Sequence:
MFTLKKSLLLLFFLGTISLSVCKQERDADYEDKGEVEEVKRGIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC
Protein: Heat shock protein 81-2 (F4K6B6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MADAETFAFQAEINQLLSLIINTFYSNKEIFLRELISNSSDVRSLSLSTLLYTCVSRLIDLADGSVDLGLALDKIRFESLTDKSKLDGQPELFIHIIPDKTNNTLTIIDSGIGMTKADLVNNLGTIARSGTKEFMEALAAGADVSMIGQFGVGFYSAYLVADKVVVTTKHNDDEQYVWESQAGGSFTVTRDTSGETLGRGTKMVLYLKEDQLEYLEERRLKDLVKKHSEFISYPISLWIEKTIEKEISDDEEEEEKKDEEGKVEEVDEEKEKEEKKKKKIKEVSHEWDLVNKQKPIWMRKPEEINKEEYAAFYKSLSNDWEEHLAVKHFSVEGQLEFKAILFVPKRAPFDLFDTKKKPNNIKLYVRRVFIMDNCEDIIPEYLGFVKGIVDSEDLPLNISRETLQQNKILKVIRKNLVKKCLELFFEIAENKEDYNKFYEAFSKNLKLGIHEDSQNRTKIAELLRYHSTKSGDELTSLKDYVTRMKEGQNDIFYITGESKKAVENSPFLEKLKKKGIEVLYMVDAIDEYAIGQLKEFEGKKLVSATKEGLKLDETEDEKKKKEELKEKFEGLCKVIKDVLGDKVEKVIVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDSSMAGYMSSKKTMEINPENSIMDELRKRADADKNDKSVKDLVLLLFETALLTSGFSLDEPNTFGSRIHRMLKLGLSIDDDDAVEADAEMPPLEDDADAEGSKMEEVD
Protein: Avirulence protein AvrBs3 (TAL effector protein AvrBs3) (P14727)
Organism: Xanthomonas euvesicatoria
Function: Avirulence protein. Acts as a transcription factor in C.annuum plants. In susceptible plants lacking the Bs3 resistance gene induces expression of a number of genes, including genes homologous to a family of auxin-induced genes, alpha-expansin genes, pectate lyase, anthocyanidin glucoside rhamnosyl transferase and at least one transcription factor, UPA20. Their expression leads to plant hypertrophy in mesophyll cells, probably mainly mediated by UPA20. In resistant plants induces the hypersensitive response (HR), by inducing transcription of plant Bs3 which induces HR; a mutated AvrBs3 missing repeats 11-14 does not induce expression of Bs3 but does induce Bs3-E, a Bs3 allele with a modified promoter. Binds DNA corresponding to the upa-box in sequence-specific manner.
Subcellular location: Secreted {ECO:0000269|PubMed:10430949, ECO:0000269|PubMed:11439138, ECO:0000269|PubMed:12366827, ECO:0000269|PubMed:15807781, ECO:0000269|PubMed:8980236}. Host nucleus {ECO:0000269|PubMed:12366827}. Note=Secreted via type III secretion system (T3SS) (PubMed:10430949, PubMed:12366827). Localizes to the plant cell nucleus in both susceptible (bs3) and resistant (Bs3) plants (PubMed:12366827). {ECO:0000269|PubMed:10430949, ECO:0000269|PubMed:12366827, ECO:0000269|PubMed:8980236}.
Interaction partners:
Sequence:
MDPIRSRTPSPARELLPGPQPDGVQPTADRGVSPPAGGPLDGLPARRTMSRTRLPSPPAPSPAFSAGSFSDLLRQFDPSLFNTSLFDSLPPFGAHHTEAATGEWDEVQSGLRAADAPPPTMRVAVTAARPPRAKPAPRRRAAQPSDASPAAQVDLRTLGYSQQQQEKIKPKVRSTVAQHHEALVGHGFTHAHIVALSQHPAALGTVAVKYQDMIAALPEATHEAIVGVGKQWSGARALEALLTVAGELRGPPLQLDTGQLLKIAKRGGVTAVEAVHAWRNALTGAPLNLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNSGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNSGGKQALETVQALLPVLCQAHGLTPEQVVAIASNSGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGRPALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGRPALESIVAQLSRPDPALAALTNDHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPERTSHRVADHAQVVRVLGFFQCHSHPAQAFDDAMTQFGMSRHGLLQLFRRVGVTELEARSGTLPPASQRWDRILQASGMKRAKPSPTSTQTPDQASLHAFADSLERDLDAPSPMHEGDQTRASSRKRSRSDRAVTGPSAQQSFEVRVPEQRDALHLPLSWRVKRPRTSIGGGLPDPGTPTAADLAASSTVMREQDEDPFAGAADDFPAFNEEELAWLMELLPQ
Protein: Transcription factor unc-86 (Uncoordinated protein 86) (P13528)
Organism: Caenorhabditis elegans
Function: Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the identity of the serotonergic NSM neurons and the cholinergic IL2 sensory and URA motor neurons. Promotes expression of the cfi-1 transcription factor in the URA and IL2 neurons which in turn activates normal URA and IL2 gene expression. Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2. Regulates expression of a number of genes in NSM neurons including bas-1, cat-1, dop-3, mgl-3, nlp-13, scd-2 and ptps-1. In the IL2 neurons, required for expression of cho-1, gcy-19, klp-6, lag-2, unc-5 and unc-17. Promotes expression of pkd-2 in the male-specific CEM head neurons. Required for dauer-specific branching of IL2Q neurons and nictation behavior. Controls both the timing and direction of axon outgrowth in HSN neurons. Plays a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the AIM, NSM, HSN and RIH neurons. Involved in regulation of lin-11 expression in the AIZ interneurons, the major interneurons of the olfactory pathway, and is required for odortaxis behavior. Involved in neurite pruning between AIM neurons during larval development by regulating the expression of transcription factor mbr-1. Required for correct localization of unc-40.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:2257628}.
Interaction partners:
- Mechanosensory protein 3
- Protein lin-32
- Homeobox protein ceh-10
- LIM/homeobox protein ttx-3
- LIM/homeobox protein ceh-14
- Transcription factor unc-3
- Zinc finger protein GFI1 homolog pag-3
- Homeobox protein unc-42
- Transcription factor egl-46
- Protein lin-11
Sequence:
MQNTAPVPTTTTASKMQPFNNSLFGSFDDPILNARAAQVALADIDVKNVPQLTNPLMRPHDMFSYSNYFSGIHDTSAATNIYQGLPSSSEPFDASVVVPTSSDDQMTPLQQVMAMQQSYGAPPPFQYNMTHPFSTTSIASSNNLARYPIAPPTSDMDTDPRQLETFAEHFKQRRIKLGVTQADVGKALAHLKMPGVGSLSQSTICRFESLTLSHNNMVALKPILHSWLEKAEEAMKQKDTIGDINGILPNTDKKRKRTSIAAPEKRELEQFFKQQPRPSGERIASIADRLDLKKNVVRVWFCNQRQKQKRDFRSQFRARSAAAVMGPRVMPVLNGNNSNNNLKQGQTTYNGLPGFFD
Protein: Zinc finger protein 16 (E9PQV1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAACGTPCCSDTELEAICPHYQQPDCDTRTEDKEFLHKEDIHEDLESQAEISENYAGDVSQVPELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNECGKTFQGN
Protein: Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (P70699)
Organism: Mus musculus (Mouse)
Function: Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P10253}. Lysosome membrane {ECO:0000250|UniProtKB:P10253}.
Interaction partners:
- Alpha-galactosidase A
- Alpha-amylase 1
- Pancreatic alpha-amylase 2a5
- Hexokinase-3
- Hexokinase-1
- Hexokinase HKDC1
- Hexokinase-2
- Neutral alpha-glucosidase C
- Sucrase-isomaltase, intestinal
- Sucrase-isomaltase, intestinal
Sequence:
MNIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEGYKPGPLHIQEQTEQPKEAPTQCDVPPSSRFDCAPDKGISQEQCEARGCCYVPAGQVLKEPQIGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFKIKDPASKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLGEHLSPLMLSTDWARITLWNRDTPPSQGTNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDSFADFPDMVRELHQDGRRYMMIVDPAISSAGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGTTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWLDMNEPSNFVRGSQQGCPNNELENPPYVPGVVGGILQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFSGHGRYAGHWTGDVRSSWEHLAYSVPDILQFNLLGVPLVGADICGFIGDTSEELCVRWTQLGAFYPFMRNHNDLNSVPQEPYRFSETAQQAMRKAFALRYALLPYLYTLFHRAHVRGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTEVTGYFPKGTWYNMQMVSVDSLGTLPSPSSASSFRSAVQSKGQWLTLEAPLDTINVHLREGYIIPLQGPSLTTTESRKQPMALAVALTASGEADGELFWDDGESLAVLERGAYTLVTFSAKNNTIVNKLVRVTKEGAELQLREVTVLGVATAPTQVLSNGIPVSNFTYSPDNKSLAIPVSLLMGELFQISWS
Protein: LITAF domain-containing protein (Q9XWU3)
Organism: Caenorhabditis elegans
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004414}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004630}.
Interaction partners:
- ADP-ribosylation factor 1-like 1
Sequence:
MSYPDDFPIPHVIQPVKVVRHVVKETPIKTPYLDVCPKCQTTIMTSVTTHIGMCWWLICFFGTFLFCWPILICLCFDVSKDVDHNCPNCGLLLATSNRAGF
Protein: NalC (Q9HXS0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Uncharacterized protein
- Antirepressor for MexR, ArmR
- Transcriptional regulator MexT
- Multidrug resistance operon repressor
- NalD
- Outer membrane protein OprM
- HTH-type transcriptional regulator NfxB
- Multidrug resistance protein MexA
- Multidrug efflux outer membrane protein OprN
- Outer membrane protein OprJ
Sequence:
MNDASPRLTERGRQRRRAMLDAATQAFLEHGFEGTTLDMVIERAGGSRGTLYSSFGGKEGLFAAVIAHMIGEIFDDSADQPRPAATLSATLEHFGRRFLTSLLDPRCQSLYRLVVAESPRFPAIGKSFYEQGPQQSYLLLSERLAAVAPHMDEETLYAVACQFLEMLKADLFLKALSVADFQPTMALLETRLKLSVDIIACYLEHLSQSPAQG