Protein: CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (A1A5H6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 3
- RNA helicase
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex, subunit 4b.
Sequence:
MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECVSLITKPNFISTLCYAIDNPLHYQKSLKPSPHLFTQLSKVLKLSKVQEVILGLALSNSSNADLRGFAAQFVKQKLPDLLRSYVDADLGGNQEGGFQDIAIEVLHLLLSHLLFGQKGSSGVGQEQIDAFLKTLCRDFPQERCPVVLAPLLYPDKRDILMDRILPDSGDLNKTMMESSLADFMQEVGYGFCASLEECRNIILQYGVREVTASQVARVLGMMARTHSGLSDGISLQTITNPVGGGGIWSDGKDKSDSSQAWNVEVLIDVVKEVNPNLNFKEVTYELDHPGFLIRDSKGLQIVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLLSPEVFCFADNPCHTVAIDTLKAPPEDDNREIATWKSLDLVESLLRLSEVGHYEQVKQLFSFPIKHCPDMLVLALLQISTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHSMAEWYMRGEQYDQAKLSRILDVAQDLKSLSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACVTFLKRRCPSIMGGLAPEKDQPKSAQLPPETLATMLACLQSCAGSVSQELSETILTMVANCSNVMNKARQPPPGVLPKGRAPSTSSLDAISPVQMDPLSAMGSLSLGVSSTSHTPSMQGFPSLQGSAFSNPQSPAKAFSNLPNPNPSTAFPGINPLSSQLQGPLSTSLSGIGSGLGMPTVSSDVFSARKMSTPGLNPPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSNIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASIAHFLQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSLALAQAQAQSQPPKAPQPGQASTLVTTATTTTTAAKTTTITRPTAVGPKKDVPPSINTTNIDTLLVATDQTERIVEPPENVQEKIAFIFNNLSQSNMSQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFVKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILYTDLELKSLLLEAYVKGQQELLYVVPFVAKVLESSLRSVIFRPQNPWTMGIMNVLAELHQEHDLKLNLKFEIEVLCKNLSMDITDLKPGNLLRDKDKLKTLEEQLSAPKKETKPPEELLPIVTTDSVPFTAAPSTPATTTACTATGPPTPQFSYHDINVYALAGLAPHININVNIPLLQAHPQLKQCVRPAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESHMRVAAHHMMRNLTAGMAMITCREPLLMSIATNLKNSFAAALRAPTPQQREMMEEAAARIAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPMVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPSNDLSQPTGFLAQPMKQQAWPTDDVAHIYEKCISDLEQHLHAIPPALAMNPQTQAIRSLLEAVVMARNSRDGIAALGLLQKAVEGLLDATSGADPELLLSYRECHLLVLKALQDGRAYGPQWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKLLLVDERSVSHITEADLFHTIETLMRTSAHSRANAPEGLPQLMDVVRSNYEAMIDRHHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHPTTSPAIIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLIQDHDVRQTEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELNKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPSQFKKDLDSYLKTRSPVTFLSELRSNLQVSNEPGNRYNIQLINALVPYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANAEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWSHDFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS