wanglab/gogpt-training-data huggingface dataset:
Protein: COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) (Q99627)
Organism: Homo sapiens (Human)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Interaction partners:
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 7a
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 7b
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 9
- Cullin-4A
Sequence:
MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
Protein: Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) (Q9UJ78)
Organism: Homo sapiens (Human)
Function: Functions as a transcriptional regulator.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEKCSVGGLELTEQTPALLGNMAMATSLMDIGDSFGHPACPLVSRSRNSPVEDDDDDDDVVFIESIQPPSISAPAIADQRNFIFASSKNEKPQGNYSVIPPSSRDLASQKGNISETIVIDDEEDIETNGGAEKKSSCFIEWGLPGTKNKTNDLDFSTSSLSRSKTKTGVRPFNPGRMNVAGDLFQNGEFATHHSPDSWISQSASFPSNQKQPGVDSLSPVALLRKQNFQPTAQQQLTKPAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTQNTRSIICKKDASTKKANVILPVESSKSFQEFYSTSCLSPCENNWNLKKGVFNKSRCTICSKLAEIRHEVSVNNVTHKLCSNHCFNKYRLANGLIMNCCEHCGEYMPSKSTGNNILVIGGQQKRFCCQSCINEYKQMMETKSKKLTASENRKRNAFREENEKQLYGSSNTLLKKIEGIPEKKEKTSQLQLSVECGTDTLLIQENVNLPPSSTSTIADTFQEQLEEKNFEDSIVPVVLSADPGTWPRILNIKQRDTLVENVPPQVRNFNFPKDNTGRKFSETYYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLFGEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKLKSDLKKNKAIDAAEHRLYENEKNDGVLLLYT
Protein: AppA, antirepressor of ppsR, sensor of blue light (Q3J677)
Organism: Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides)
Interaction partners:
- Transcriptional regulator, PpsR
- Photosynthetic apparatus regulatory protein RegA
- Sensor histidine kinase RegB
- Transcriptional activator protein FnrL
- Intrinsic membrane protein PufX
- Regulatory protein, PpaA
- TspO and MBR related proteins
Sequence:
MQHDLEADVTMTGSDLVSCCYRSLAAPDLTLRDLLDIVETSQAHNARAQLTGALFYSQGVFFQWLEGRPAAVAEVMTHIQRDRRHSNVEILAEEPIAKRRFAGWHMQLSCSEADMRSLGLAESRQIVTVGRSLVADNTNIFSFDRIAAVRRFLSDVCAARTLAPDTPVEADTFALYALTEAQAGRSGRAKAVARLSDLLSTDPLGRLTEVEELLRAHAPTAADFARLFEACAERLTRALAEDRISRMQVTLAYSALQMALRRIHHLPDPQKSVGAVLVAGVPGHKPILEAALAAEMLRAVGWSTSVVHPESVAALAARLKTSRTSTLVVAPSLLEGTEQEADTLRFVSALRARTDLPGLSILVGGRLAQLPPSKLKDSGADAGFAHLALLPAALARVACPANADCCSMRACRMPASQCCDKRINPEFLLANVMPSVLTRISSRQDRRRSA
Protein: Uncharacterized protein (Q38DT4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSILVNRRSVSIDYKDDNDTRYIDEWGGDGGRFSRTRSGTQKFGRASTRRASVPNPTPLRKERVARAPPSPREEPTPLRKHARRSDPAAFSHLLLPTTASKARAQSKYVERKNGHGGEPSTGSRSVSPVATNAGSRLYALAMAQLKHIAEKRAESERKLKEQEDKLTFKPKITSTSRLLCAGGYRPPHECYKEVQSRAIEKRRMREQVILMKSDSDCTFRPTLTANSMTLADKLRKDDPFTDVGDRLCFEGGCRLVRQQLRRQIIQQREERRVISGFSISPRRADRLVRRLYNWQKECDRKKDAAAKEPLLPSGRTTVSGRRRLSSRGSSSSRRR
Protein: GTPase KRas isoform 2 (EC 3.6.5.2) (K-ras) (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) (Q6AZA4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLQSHNVDSKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKEGKKKKKKSKTKCALM
Protein: Tubulin beta-5 chain (P99024)
Organism: Mus musculus (Mouse)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26637975}.
Interaction partners:
- Tubulin alpha-1B chain
- Tubulin alpha-1A chain
- Microtubule-associated protein
- Tubulin alpha-4A chain
- Tubulin alpha-1C chain
- Tubulin alpha-8 chain
- Tubulin alpha chain-like 3
- Tubulin alpha-3 chain
- Gap junction alpha-1 protein
- Tubulin beta-4B chain
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
Protein: At1g17620/F11A6_23 (F1L3.32) (Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family) (Q9LNP3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTDDRVYPASKPPAIVGGGAPTTNPTFPANKAQLYNANRPAYRPPAGRRRTSHTRGCCCRCCCWTIFVIILLLLIVAAASAVVYLIYRPQRPSFTVSELKISTLNFTSAVRLTTAISLSVIARNPNKNVGFIYDVTDITLYKASTGGDDDVVIGKGTIAAFSHGKKNTTTLRSTIGSPPDELDEISAGKLKGDLKAKKAVAIKIVLNSKVKVKMGALKTPKSGIRVTCEGIKVVAPTGKKATTATTSAAKCKVDPRFKIWKITF
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2) (Q00722)
Organism: Homo sapiens (Human)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel subfamily M member 5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-15
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-14
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Guanine nucleotide-binding protein subunit alpha-11
Sequence:
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
Protein: Cysteine synthase 1 (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL) (Q93244)
Organism: Caenorhabditis elegans
Function: Catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1-mediated transcription, regulates behavioral responses to hypoxia.
Interaction partners:
- Putative cystathionine gamma-lyase 2
- cystathionine gamma-lyase
- Hypoxia-inducible factor prolyl hydroxylase
- FAD/NAD
- Aspartate aminotransferase, cytoplasmic
- Cysteine dioxygenase 1
- Probable phosphoserine aminotransferase
- Sulfide:quinone oxidoreductase, mitochondrial
- Kynurenine--oxoglutarate transaminase
- Kynurenine--oxoglutarate transaminase
Sequence:
MADRNSIGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNTGIALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLYTDIRESAMALAVESLEANLKKLCLHNYDIME
Protein: Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase 1) (ADPRT-1) (Poly[ADP-ribose] synthase 1) (Protein ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (Q9ZP54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00264}.
Interaction partners:
- Poly
- Probable poly
- Poly [ADP-ribose] polymerase 2
- ATP-dependent DNA helicase 2 subunit KU80
- ATP-dependent DNA helicase 2 subunit KU70
- Protein ADP-ribosyltransferase PARP3
- DNA-repair protein XRCC1
- DNA ligase 4
- DNA ligase 1
- Protein BREAST CANCER SUSCEPTIBILITY 1 homolog
Sequence:
MASPHKPWRAEYAKSSRSSCKTCKSVINKENFRLGKLVQSTHFDGIMPMWNHASCILKKTKQIKSVDDVEGIESLRWEDQQKIRKYVESGAGSNTSTSTGTSTSSTANNAKLEYGIEVSQTSRAGCRKCSEKILKGEVRIFSKPEGPGNKGLMWHHAKCFLEMSSSTELESLSGWRSIPDSDQEALLPLVKKALPAAKTETAEARQTNSRAGTKRKNDSVDNEKSKLAKSSFDMSTSGALQPCSKEKEMEAQTKELWDLKDDLKKYVTSAELREMLEVNEQSTRGSELDLRDKCADGMMFGPLALCPMCSGHLSFSGGLYRCHGYISEWSKCSHSTLDPDRIKGKWKIPDETENQFLLKWNKSQKSVKPKRILRPVLSGETSQGQGSKDATDSSRSERLADLKVSIAGNTKERQPWKKRIEEAGAEFHANVKKGTSCLVVCGLTDIRDAEMRKARRMKVAIVREDYLVDCFKKQRKLPFDKYKIEDTSESLVTVKVKGRSAVHEASGLQEHCHILEDGNSIYNTTLSMSDLSTGINSYYILQIIQEDKGSDCYVFRKWGRVGNEKIGGNKVEEMSKSDAVHEFKRLFLEKTGNTWESWEQKTNFQKQPGKFLPLDIDYGVNKQVAKKEPFQTSSNLAPSLIELMKMLFDVETYRSAMMEFEINMSEMPLGKLSKHNIQKGFEALTEIQRLLTESDPQPTMKESLLVDASNRFFTMIPSIHPHIIRDEDDFKSKVKMLEALQDIEIASRIVGFDVDSTESLDDKYKKLHCDISPLPHDSEDYRLIEKYLNTTHAPTHTEWSLELEEVFALEREGEFDKYAPHREKLGNKMLLWHGSRLTNFVGILNQGLRIAPPEAPATGYMFGKGIYFADLVSKSAQYCYTCKKNPVGLMLLSEVALGEIHELTKAKYMDKPPRGKHSTKGLGKKVPQDSEFAKWRGDVTVPCGKPVSSKVKASELMYNEYIVYDTAQVKLQFLLKVRFKHKR
Protein: Soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative (Q4GYR2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Syntaxin 5
- Gamma-soluble NSF attachment protein
- SNARE protein, putative
- Vesicle-fusing ATPase
- t-SNARE coiled-coil homology domain-containing protein
- Target SNARE, putative
- Golgi SNARE protein-like
- Vesicle-associated membrane protein, putative
- Sec1 family transport protein, putative
Sequence:
MSAESIYRDAEKKLKKWFFVDYDEAMELFEKAAGRFKAERNYSRAGDAFMKAHDCAMRSKNPVAAGRFCSEAVVMYQKTDRTKAAALLDMAVRTQIDNNKLREAAKLEKDYADAIYEDGHGMEAITHYEKARRYFDAEDYKSQVKNCDVAIANIYGENDMFDKALALFERLGNTSASGPLRHEAKEFYMRAMLCRLASIGEDNREVGSAEAAEALSAYMKRDPYLKNTREAESLQKLLEAVEESNEEKFEDAVSLLQELRMLDEWKTHVLLVVKNKMSSLL
Protein: NAC (No Apical Meristem) domain transcriptional regulator superfamily protein (T13D8.21 protein) (O80755)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA replication ATP-dependent helicase/nuclease JHS1
Sequence:
MEDNDAAYDQVKSELLNSEDEVIISRYLKPMVVNGDSWPDHFIEDANVFTKNPNEVFNSERPRFVIVKPRTEACGKTDGCESGCWRTMGRDKLIKSEETGKILGFKKILKFCIKWKPIEYKRSWVMEEYRLTNNLNWKQDHVICKIRLLFEAEISFLLAKHFYTTSESLLRHELLPSYGYLSNTQEEDEFYLKTIMTSEGNDWPSYVTNNVYCLHPLELVDLQDVMFQSYGTCIFANGTCGESDKCDGGYWKILHGDKLIKSNFGMVTGFKKVFEFYETVIHRYFCDGEEVKEETERLGHQRCQGLLLPHRRGHVQTKSCGVVTVKEKRSLVEQPEEIVAAPETPRQGKSEHNDPLKRKKAIGCVGEKAEM
Protein: Phosphoenolpyruvate/phosphate translocator 2, chloroplastic (OsPPT2) (Q84QU8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Phosphoenolpyruvate/phosphate translocator that transports phosphoenolpyruvate (PEP) and dihydroxyacetone phosphate.
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MQSAAAAFGLVRPCPARPPLQLGPGSSSCRPILLHARPLAAGIASSSRGPAAVAARSLGRLLLLPPPPPISPDRAGRGRARHVACGAAAGDAKAEEEESGLAKTLQLGALFGLWYLFNIYFNIYNKQVLKVFPYPINITTVQFAVGTVVALFMWITGILRRPKISGAQLFAILPLAVVHTMGNLFTNMSLGKVAVSFTHTIKAMEPFFSVLLSAIFLGELPTVWVILSLLPIVGGVALASLTEASFNWAGFWSAMASNVTFQSRNVLSKKLMVKKEESLDNINLFSIITVMSFFLLAPVAFLTEGIKITPTVLQSAGLNVKQVLTRSLLAALCFHAYQQVSYMILARVSPVTHSVGNCVKRVVVIVTSVLFFRTPVSPINSLGTAIALAGVFLYSQLKRLKPKPKAA
Protein: Type 3 secretion system secretin (T3SS secretin) (YscC secretin) (Q01244)
Organism: Yersinia enterocolitica
Function: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. It may serve as an injectisome assembly platform. Essential for the export of Yop proteins.
Subcellular location: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000269|PubMed:15292137, ECO:0000269|PubMed:24207124, ECO:0000269|PubMed:9427408}. Note=Localization to the outer membrane requires YscW/SctG. {ECO:0000269|PubMed:15292137}.
Interaction partners:
Sequence:
MAFPLHSFFKRVLTGTLLLLSSYSWAQELDWLPIPYVYVAKGESLRDLLTDFGANYDATVVVSDKINDKVSGQFEHDNPQDFLQHIASLYNLVWYYDGNVLYIFKNSEVASRLIRLQESEAAELKQALQRSGIWEPRFGWRPDASNRLVYVSGPPRYLELVEQTAAALEQQTQIRSEKTGALAIEIFPLKYASASDRTIHYRDDEVAAPGVATILQRVLSDATIQQVTVDNQRIPQAATRASAQARVEADPSLNAIIVRDSPERMPMYQRLIHALDKPSARIEVALSIVDINADQLTELGVDWRVGIRTGNNHQVVIKTTGDQSNIASNGALGSLVDARGLDYLLARVNLLENEGSAQVVSRPTLLTQENAQAVIDHSETYYVKVTGKEVAELKGITYGTMLRMTPRVLTQGDKSEISLNLHIEDGNQKPNSSGIEGIPTISRTVVDTVARVGHGQSLIIGGIYRDELSVALSKVPLLGDIPYIGALFRRKSELTRRTVRLFIIEPRIIDEGIAHHLALGNGQDLRTGILTVDEISNQSTTLNKLLGGSQCQPLNKAQEVQKWLSQNNKSSYLTQCKMDKSLGWRVVEGACTPAQSWCVSAPKRGVL
Protein: Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) (Q12986)
Organism: Homo sapiens (Human)
Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Subcellular location: Nucleus.
Interaction partners:
- Ubiquitin-protein ligase E3A
- Polyadenylate-binding protein 1
- HLA class II histocompatibility antigen, DR alpha chain
- Presenilin-1
- Large ribosomal subunit protein eL22
- Heterogeneous nuclear ribonucleoprotein Q
- Ciliary neurotrophic factor receptor subunit alpha
- Small ribosomal subunit protein eS19
- Paired amphipathic helix protein Sin3a
Sequence:
MAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVYSYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEGHRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKYECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCECGRRKEMVICSEASSTYQRIAAISMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERKKRLAEAFHISEDSDPFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD
Protein: Proliferating cell nuclear antigen (PCNA) (Cyclin) (Mutagen-sensitive 209 protein) (P17917)
Organism: Drosophila melanogaster (Fruit fly)
Function: Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility.
Subcellular location: Nucleus {ECO:0000269|PubMed:17087725, ECO:0000269|PubMed:9310333}. Chromosome {ECO:0000269|PubMed:17087725}. Cytoplasm {ECO:0000269|PubMed:17087725}. Note=Colocalizes with crm in polytene nuclei during embryogenesis (PubMed:9310333). Increased association with chromatin in response to DNA damage caused by methyl methanesulfonate (MMS), hydrogen peroxide (H2O2) and UV (PubMed:17087725). {ECO:0000269|PubMed:17087725, ECO:0000269|PubMed:9310333}.
Interaction partners:
- Replication factor C subunit 2
- Flap endonuclease 1
- Replication factor C subunit 3
- Replication factor C subunit 2
- DNA ligase 1
- Activator 1 subunit 5
- Probable DNA mismatch repair protein Msh6
- DNA replication licensing factor Mcm7
- DNA replication licensing factor Mcm2
- DNA polymerase delta catalytic subunit
Sequence:
MFEARLGQATILKKILDAIKDLLNEATFDCSDSGIQLQAMDNSHVSLVSLTLRSDGFDKFRCDRNLSMGMNLGSMAKILKCANNEDNVTMKAQDNADTVTIMFESANQEKVSDYEMKLMNLDQEHLGIPETDFSCVVRMPAMEFARICRDLAQFSESVVICCTKEGVKFSASGDVGTANIKLAQTGSVDKEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSTQVQLSMCADVPLVVEYAIKDLGHIRYYLAPKIEDNET
Protein: Rap-GAP domain-containing protein (G5EBY5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSSTTSSVRSANRTRSLCHHLHHQPLLVSGSSTGSPPIGGSMDEGSSASTSSSATARALDMFNRRGSVLAVVIAGNTAADVLPPSAGVPNTSAVSSSSGVISADQPSSTNSDNDTETFNEWRPPFPRLSAYQDCLSLAAAWGLGMHPNGLDDKPTGASQAQSPSEDDSGDGKFNELLASCPAFRNELGWEPTRRFALSRHTFDMAHTDAHECETWMREHSASEAGILEDVSNVYLGGRLCAARQPKTVIEPQDIGSYYYRHCFISKNHIEYLGMDDILGPISISMVREIVDRKESYSIYRMIVRISDQKTIRVAVPEEALSTPEGSDRATRPLMRELLEIVCPKISFGILRPSIQSPRVEELIMKIDEQPIYTRYKVGIMLCKNEQSTEEQMYNNEFSTPSFDEFLDFLGQRVTLKGFEAYKGGLDTRGDTTGTHSIYSEYQAHEIMFHVSTLLPFTPSNRQQLSRKRHIGNDMVTIVFQEPGALPFSPITVRSHFQHVFIIVRVHNECSENVTYSVAVSRSKDVPAFGPPVPKGACFSKCAEFHDWLLTKIINAENAVHRSKKFATMAARTRREALRDLVENYVGPHQNEGASKIASRFLGGSVKRKERHNPKPTNHVMRGALSWLVDVHDYSTNQRISCVLGVAQDWIVLLERPSGTVLFSTPTHSIIGWATSDTGLKLYYDHGDQLLLRCYSETCTDSELNELIRRLENVTKGDEAKEVVLRRLKTTDNWGFHVQDEGVVTDVEMYQLAWKAGIRQGSRIVEMDSMPISTLSFDKICDQLAVSECVRLLMISPSSDGSPRRGCEDPNCPAVKGIEQMLTPDAFAKQPITRYHEMFRQKKLEYPTNSASSSPASSFDERTFSFTATKKTIEQRANNISNNRPNTLSSASVHDNMCTLLNPPKYLNRAQSDEQLRSPLMDELNRKAPLSARESTNERESSELVRIQTHLERTVQEKRALEMLAQQLKKQLIQERQSHDNTKREMERLKKMYEKK
Protein: Triadin (Q13061)
Organism: Homo sapiens (Human)
Function: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22422768}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}; Single-pass type II membrane protein {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}.
Interaction partners:
- Ryanodine receptor 2
- Calsequestrin-2
- Aspartyl/asparaginyl beta-hydroxylase
- Calsequestrin-1
- Ryanodine receptor 1
- Sarcoplasmic reticulum histidine-rich calcium-binding protein
- Peptidyl-prolyl cis-trans isomerase FKBP1B
- Calmodulin-1
- Junctophilin-2
- Junctophilin-1
Sequence:
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ
Protein: alanine transaminase (EC 2.6.1.2) (A0A8I6GJ17)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
DIRCILQLGIKKPFTEVIRANIGDAHAMGQQPITFLRQHSFLRGALGDGGFMVYVRISMAECCMDRQYWIGRQETGNEVMALCTYPNLLNSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDGVPADPDNIYLTTGASDGISVCAKTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEDNCWALNVDELRRALRQAKDHCDPKVLCIINPGNPTGVSHHTQLNFRTVTDYFKLGGGRSDGDGDDDGGGGGGGDDDDDDDDDVTGIYSGSLDSNCDFQVYQDNVYSPDCRFHSFKKVLYQMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVPGEESFEQFTRGHGKGTATTPCGQLPVVCLGVSIHGRLSRGTVNSKIQTTKLTLILPWEAEGGEPEKESVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRQEAERANSKGEESFERPPVIYFLHKATTPNLPQLTANLAAKQSNAQDLWEGMSMASEKIEEAQHWKRGATPGVVNNLQLSWEAQDLCATGVHTGELMVWRYKMSVLPDGLQHHPEATTEARVFLRQMKSGLLLGHELHSPTKFLFVECVRRDPPPSHIPRYIDSYFMKGL
Protein: Cysteine sulfinic acid decarboxylase (F1QG14)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Alanine--glyoxylate aminotransferase 2
- Cysteine dioxygenase type 1
- 2-aminoethanethiol
- Si:ch73-337l15.2.
- 2-aminoethanethiol
- Glutathione hydrolase
- Gamma-glutamyltransferase 5a
- Gamma-glutamyltransferase 1a.
- Glutathione hydrolase
- Gamma-glutamyltransferase 1-like 2.1.
Sequence:
MTNRACASTYMKAGPCIKAPRVPRHPLLIVEFHVLSTETTLNITMSSSGEYMNGHVHLEESDMDESDGKLFLTEAFNIIMEEILNKGRDLKEKVCEWKDPDQLRSLLDLELRDHGECHEKLLQRVRDVAKYSVKTCHPRFFNQLFAGVDYHALTGRLITETLNTSQYTYEVAPVFVLMEEEVISKLRSLVGWSEGDGIFCPGGSMSNMYAINVARYWAFPQVKTKGLWAAPRMAIFTSQQSHYSVKKGAAFLGIGTENVFIVQVDESGSMIPEDLEAKIVQAKSQDAVPFFVNATAGTTVQGAFDPLKRIADICERNGMWMHVDAAWGGSVLFSKKHRHLVAGIERANSVTWNPHKMLLTGLQCSVILFRDTTNLLMHCHSAKATYLFQQDKFYDTSLDTGDKSIQCGRKVDCLKLWLMWKAIGASGLSQRVDKAFALTRYLVEEMEKRENFQLVCKGPFVNVCFWFIPPSLKGKENSPDYQERLSKVAPVIKERMMKRGTMMVGYQPMDEHVNFFRMVVVSPQLTTKDMDFFLDEMEKLGKDL
Protein: P1R3 (A0A384L5D0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRTLKTQTTRGRRRANVSSRTRVLHTCCGNGSSDGGKTVMEKLLALKSLLPPPVNVGGGETEELFQETAEYIVKLRTQVVVLKKLIEIYDNSSDQKKDVVL
Protein: Retinoic acid early-inducible protein 1-delta (RAE-1-delta) (Q9JI58)
Organism: Mus musculus (Mouse)
Function: Acts as a ligand for KLRK1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10894171}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10894171}.
Interaction partners:
- NKG2-D type II integral membrane protein
- Retinoic acid early-inducible protein 1-epsilon
- UL16 binding protein 1
Sequence:
MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKAPTPADEVKCFVGEILILHLSNINKTMTSGDPGETANATEVGECLTQPLKDLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTEIMSWRSANDESGVIMNKWKDDGEFVKQLKFLIHGCSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPTSHSTSKKGFISVGLIFISLLFAFAFAM