wanglab/gogpt-training-data huggingface dataset:
Protein: Putative MAPK activating protein (Transformer-2 alpha, isoform CRA_a) (cDNA, FLJ95674, Homo sapiens transformer-2 alpha (htra-2 alpha) (HSU53209), mRNA) (Q549U1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY
Protein: Cardioacceleratory peptide receptor (Crustacean cardioactive peptide receptor) (Q868T3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to the cardioactive peptide (CCAP), which is a neuropeptide.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12177421, ECO:0000269|PubMed:12646179}; Multi-pass membrane protein {ECO:0000269|PubMed:12177421, ECO:0000269|PubMed:12646179}.
Interaction partners:
- Cardioactive peptide
- G protein alpha s subunit subunit alpha)
- Guanine nucleotide-binding protein subunit beta-1
- G protein beta subunit 5
- Guanine nucleotide-binding protein G
- Bursicon
- Diuretic hormone 31 receptor, isoform C
Sequence:
MLHLRLFDSSLYYTLASASESSGLASSTSTERSFNGTQGAGGVAAGGESLTPTDVAAVNLTYFTPAISHVMLAPTTIATTTASATMVQIQTTAAPSHDLETGGNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPMNFSKSWKRARHLVAGAWLISALFSLPILVLYEEKLIQGHPQCWIELGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPARRASSRGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSMRTLTTSLTVSRRSTNKTNARVVICERPTKVVTVPAMSERV
Protein: Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Q91ZY6)
Organism: Rattus norvegicus (Rat)
Function: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Meiotic nuclear division protein 1 homolog
- Meiotic recombination protein
Sequence:
MSKSRAEAAAGAPGIVLRYLQEQNRPYSAQDVFGNLQKEHGLGKAAVVKALDQLAQQGKIKEKTYGKQKIYFADQDQFDTVSDADLHSLDASIMALTAKVQGLQQSCRHMEAELKELTSALTTPEMQTEIQELKKECARYTERLKNIKAATNHVTPEEKEKVYRERQKYCKEWRKRKRMTTELCDAILEGYPKSKKQFFEEVGIETDEDHNVTLPNP
Protein: BEN domain-containing protein 3 (Q5T5X7)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities.
Subcellular location: Nucleus {ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:25600804}. Nucleus, nucleolus {ECO:0000269|PubMed:26100909}. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. {ECO:0000269|PubMed:21914818}.
Interaction partners:
- DNA excision repair protein ERCC-6-like
Sequence:
MNSTEFTEDVEEVLKSITVKVETEAEDAALDCSVNSRTSEKHSVDSVLTALQDSSKRKQLVSDGLLDSVPGVKRRRLIPEALLAGMRNRENSSPCQGNGEQAGRGRSLGNVWPGEEEPCNDATTPSYKKPLYGISHKIMEKKNPPSGDLLNVYELFEKANASNSPSSLRLLNEPQKRDCGSTGAGTDNDPNIYFLIQKMFYMLNTLTSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVASFFEAEQVDPGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLDAGSEGDPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLTSYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTAENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK
Protein: TEA domain transcription factor 1 (H0YCZ6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMY
Protein: Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (Q9JLT2)
Organism: Mus musculus (Mouse)
Function: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P19813}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19813}.
Interaction partners:
- Catalase
- Protein YIPF6
- Protein-glucosylgalactosylhydroxylysine glucosidase
Sequence:
MTWELHLLLLLGLGLRSQEALPPPCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELATVHNHSIPKEQLQEFVQSHFQPVGQELQSWTPEDWKDSPQFLQKISDANLRVWAEELHKIWKKLGKKMKAEVLSYPERSSLIYSKHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRIYYLQRSQPPLLTLMMDRYVAHTKDVAFLQENIGTLASELDFWTVNRTVSVVSGGQSYVLNRYYVPYGGPRPESYRKDAELANSVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEATKYRNLRAQRLAAMEAVLWDEQKGAWFDYDLEKGKKNLEFYPSNLSPLWAGCFSDPSVADKALKYLEDSKILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSAMFEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLVAALLLSLLLQ
Protein: Betacellulin (A0A8I5ZSF9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
GRKGSCCRLLGCAQVAPWSARSEASRRCWQGPGRCLAGLVILQCVVADGNTTRTPETNGSLCGAPGENCTGTTPRQKSKTHFSRCPKQYKHYCIHGRCRFVMDEQTPSCICEKGYFGARCEQVDLFYLQQDRGQILVVCLIGVMVLFIILVIGVCTCCHPLRKHRKKKKEEKMETLSKDKTPISEDIQETNIA
Protein: ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (Q9VQR3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|HAMAP-Rule:MF_03176}. Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03176}.
Interaction partners:
- Origin recognition complex subunit 5
- DNA replication ATP-dependent helicase/nuclease
- Proliferating cell nuclear antigen
- Proliferating cell nuclear antigen 2
- Histone chaperone asf1
- GEO08380p1
- RecQ-like DNA helicase Blm
- Replication protein A 70 kDa DNA-binding subunit
- DNA repair protein Rad51 homolog
- DNA polymerase alpha subunit B
Sequence:
MDLNDAVLTCAVNMEWTNAVGITGRKLAYKTATLRLVRNDLRELFVEVTPEKLKPLKFKLKDLMVHKKFMSEGKATFNFKAEKCTLYLSNAPPGTLMFFLRTIFVKMNGNEGGSQPDDATLQKKLREHLMSGKPSSFNDVSPVTTAEMILARKKAGLLSKGSVTTPSPQGAKKRRFEELKEEKERGTMPAAKKLYASTTDESLRLSEEQMEVLRACTSGKSVFFTGSAGTGKSFLLRRIISALPPDGTVATASTGVAACLIGGTTLHAFAGIGGGDATMQRCLELASRPANAQTWRKCKRLIIDEISMVDGQFFEKIEAVARHIRRNDRPFGGIQLILCGDFLQLPPVIKGDFGAAPTATPQQRFCFQSSAWETCIQCVYELKQVHRQSDPEFVKILNHLRIGHVNDSITSRLAATSKQKIEGNGILATQLCSHTNDANSINESKLENLDGDKILFKADDSDASMTRTLDQQIQAPSQLYLKVNAQVMLLKNINISNGLVNGARGVVVRMEKDLPVVRFKNNQEYVCKHERWIIKTASGNHITRRQVPLKLAWAFSIHKSQGLTLDCVEMSLSKVFEAGQAYVALSRAKSLQSIRILDFDAKQVWANPHVLQFYKGFRRKLMDTTMIPLGPKNKDKKPGDKAANSALAKLKKSLINKPLVSIS
Protein: Uncharacterized symporter YidK (P31448)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized sulfatase YidJ
- Uncharacterized protein YhiJ
Sequence:
MNSLQILSFVGFTLLVAVITWWKVRKTDTGSQQGYFLAGRSLKAPVIAASLMLTNLSTEQLVGLSGQAYKSGMSVMGWEVTSAVTLIFLALIFLPRYLKRGIATIPDFLEERYDKTTRIIIDFCFLIATGVCFLPIVLYSGALALNSLFHVGESLQISHGAAIWLLVILLGLAGILYAVIGGLRAMAVADSINGIGLVIGGLMVPVFGLIAMGKGSFMQGIEQLTTVHAEKLNSIGGPTDPLPIGAAFTGLILVNTFYWCTNQGIVQRTLASKSLAEGQKGALLTAVLKMLDPLVLVLPGLIAFHLYQDLPKADMAYPTLVNNVLPVPMVGFFGAVLFGAVISTFNGFLNSASTLFSMGIYRRIINQNAEPQQLVTVGRKFGFFIAIVSVLVAPWIANAPQGLYSWMKQLNGIYNVPLVTIIIMGFFFPRIPALAAKVAMGIGIISYITINYLVKFDFHFLYVLACTFCINVVVMLVIGFIKPRATPFTFKDAFAVDMKPWKNVKIASIGILFAMIGVYAGLAEFGGYGTRWLAMISYFIAAVVIVYLIFDSWRHRHDPAVTFTPDGKDSL
Protein: Putative methylesterase 11, chloroplastic (AtMES11) (EC 3.1.1.-) (Q9FW03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative methylesterase.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
Sequence:
MGNLCSLFTPPKPVKKRKPITKRQSSIGASSSGSGLNSNRWNNRVRSSSSRRDNKFEDALIQEHALAAAAVLFRQQNGGGGSLPFDRSASQRYQGSCSKKNQLPRSSSSRSRSSTDPLLQPHQFLNQGIKLDDLETNHFVLVHGGSFGAWCWYKTIALLEEDGFKVTAIDLAGCGINSININGIASLSQYVKPLTDILEKLPIGEKVILVGHDFGGACISYAMELFPSKISKAVFLAAAMLTNGQSTLDMFSLKAGQNDLMRKAQIFIYTNGNENPPTAIDLDKSLLKDLLFNQSPSKDVALASVSMRSIPFAPVLEKLSLSDANYGSVRRYYIETLEDNAIPVTLQENMINSSPPEKVYRLKGADHAPFFSKPQALHKLLLEIARISPA
Protein: Syntaxin-5 (Q13190)
Organism: Homo sapiens (Human)
Function: Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q08851}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:27795424}. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000269|PubMed:27795424}.
Interaction partners:
- Golgi SNAP receptor complex member 2
- Synaptobrevin homolog YKT6
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Sec1 family domain-containing protein 1
- Vesicle-trafficking protein SEC22b
- Golgi SNAP receptor complex member 1
- BET1 homolog
- BET1-like protein
- Vesicle-associated membrane protein 4
- Vesicle transport through interaction with t-SNAREs homolog 1B
Sequence:
MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAGSSSSDIAPLPPPVTLVPPPPDTMSCRDRTQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSALPLAPNHLGGGAVVLGAESHASKDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA
Protein: NAC transcription factor 29 (AtNAC029) (Protein NAC-LIKE, ACTIVATED BY AP3/PI) (AtNAP) (O49255)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds to, and transactivates the promoter of the abscisic aldehyde oxidase AAO3. Promotes chlorophyll degradation in leaves by enhancing transcription of AAO3, which leads to increased levels of the senescence-inducing hormone abscisic acid (ABA). Involved in the control of dehydration in senescing leaves. Binds to the DNA sequence 5'-CACGTAAGT-3' of SAG113 promoter. SAG113 acts as negative regulator of ABA signaling for stomatal closure in leaves, and controls water loss during leaf senescence. Transcription factor of the NAC family involved in senescence. May function in the transition between active cell division and cell expansion. Required for normal seed development and morphology.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:16640597}.
Interaction partners:
- Probable protein phosphatase 2C 78
- Magnesium dechelatase SGR1, chloroplastic
- AT2G01100 protein
- Senescence-specific cysteine protease SAG12
- Auxin-responsive protein IAA14
- Protein ETHYLENE INSENSITIVE 3
- Probable chlorophyll
- Pheophorbide a oxygenase, chloroplastic
- Ethylene-insensitive protein 2
- Senescence-associated protein 13
Sequence:
MEVTSQSTLPPGFRFHPTDEELIVYYLRNQTMSKPCPVSIIPEVDIYKFDPWQLPEKTEFGENEWYFFSPRERKYPNGVRPNRAAVSGYWKATGTDKAIHSGSSNVGVKKALVFYKGRPPKGIKTDWIMHEYRLHDSRKASTKRNGSMRLDEWVLCRIYKKRGASKLLNEQEGFMDEVLMEDETKVVVNEAERRTEEEIMMMTSMKLPRTCSLAHLLEMDYMGPVSHIDNFSQFDHLHQPDSESSWFGDLQFNQDEILNHHRQAMFKF
Protein: Inner membrane protein YgfX (G4V4G3)
Organism: Serratia sp. (strain ATCC 39006) (Prodigiosinella confusarubida)
Function: Required for production of prodigiosin antibiotic (Pig); overproduction in ygfX, sdhE or double sdhE-ygfX deletion mutants leads to nearly 10-fold increased synthesis of Pig. Overexpressing cells have somewhat altered cell length depending on growth phase. Does not function as a toxin; overexpression in the presence or absence of sdhE (the putative antitoxin) has no effect on growth rate.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:22474332, ECO:0000305|PubMed:23657679}; Multi-pass membrane protein {ECO:0000305|PubMed:23657679}.
Interaction partners:
- FAD assembly factor SdhE
Sequence:
MVQWQCNLRVSWRMQLFSLLAHGLLVLLILLAPWPDGYMSVWLGLVTLVMFGFIRSQRNIKSRHGEIVLYNENHLRWQHREWQITKRPWVLKNGILLSLRTTEGKGPRRRSLWLASDSMRNEEWRHLCHLLLQHKNWQSDRLM
Protein: Pyruvate kinase (EC 2.7.1.40) (Q9M057)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- L-lactate dehydrogenase
- Cytosolic enolase 3
- Enolase 1, chloroplastic
- Bifunctional enolase 2/transcriptional activator
- D-lactate dehydrogenase [cytochrome], mitochondrial
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
- Inosine triphosphate pyrophosphatase
- Malate dehydrogenase 3, cytoplasmic
- Malate dehydrogenase 1, cytoplasmic
- Malate dehydrogenase 2, cytoplasmic
Sequence:
MEMLLGGQATNGALRSKTKIICTLGPVSRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILSAVMLDTKGPEIRTGFLKEGKPIQLNQGQEITISIDYMIEGDSNVISMSYKKLAEDVKPGDVILCSDGTISLTVLSCDKSFGLVRCRCENSAILGERKNVNLPGIVVDLPTLTEKDKEDIIQWGVPNKIDIIALSFVRKGSDLTEVRRLLGEHSKNIMLMSKVENQEGVMNCEKILENSDAFMVARGDLGMEIPIEKMFLAQKTMIKMANALGKPVVTATQMLESMTVSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAHPEAAVLTMSRICKEAEDFIDYDILHKKTLGMVSLPLSPIESLAASVVSTAQSVFASAIVVLTKGGYTAELVAKYRPSVPILSVIVPEIAQGNDMEMSCSDSVAHAARRGLIYRRIIPVVATGSSARDSNKDATEEMINLAIGFAKTKGICKNGDSIVALHKIDGSSVVKIVTVE
Protein: Melanocortin-2 receptor accessory protein (Fat cell-specific low molecular weight protein) (Fat tissue-specific low MW protein) (Q9D159)
Organism: Mus musculus (Mouse)
Function: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). {ECO:0000250}.
Interaction partners:
- Adrenocorticotropic hormone receptor
- Pro-opiomelanocortin
Sequence:
MANGTDASVPLTSYEYYLDYIDLIPVDEKKLKANKHSIVIALWLSLATFVVLLFLILLYMSWSGSPQMRHSPQPQPICSWTHSFNLPLCLRRASLQTTEEPGRRAGTDQWLTQQSPSASAPGPLALP
Protein: Dynein regulatory complex protein 12 (Coiled-coil domain-containing protein 153) (Dynein regulatory complex subunit 12 homolog) (Q494R4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q22RH5}.
Interaction partners:
Sequence:
MPPKNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFGLTPPGSLRPPAPSL
Protein: Deacetylase Oant_2987 (EC 3.1.1.-) (A6X391)
Organism: Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi)
Function: Esterase that catalyzes the deacetylation of acetyl-(R)-mandelate (in vitro). Can also hydrolyze acetyl glycolate, but with lower efficiency. Has very low N-acetyl-D-amino acid deacetylase activity with N-acetyl-D-serine and N-acetyl-D-threonine (in vitro). Theoretical substrate docking studies suggest that other N-acetylated amino acids may optimally occupy the active site and may in fact be the physiological substrates.
Interaction partners:
- Pyridoxal phosphate-dependent enzyme, putative
- Aspartate carbamoyltransferase catalytic subunit
- Dihydroorotase, multifunctional complex type
- Dihydroorotate dehydrogenase
- Dihydroorotase, multifunctional complex type
- Binding-protein-dependent transport systems inner membrane component
- Binding-protein-dependent transport systems inner membrane component
- Extracellular solute-binding protein family 5
- L-seryl-tRNA
Sequence:
MISGEQAKPLLITNVKPVAFGVEHSDATTDILVGKDGSISAIGKSLNAPADVERVDGKGAWISPGWVDLHVHIWHGGTDISIRPSECGAERGVTTLVDAGSAGEANFHGFREYIIEPSKERIKAFLNLGSIGLVACNRVPELRDIKDIDLDRILECYAANSEHIVGIKVRASHVITGSWGVTPVKLGKKIAKILKVPMMVHVGEPPALYDEVLEILGPGDVVTHCFNGKSGSSIMEDEDLFNLAERCSGEGIRLDIGHGGASFSFKVAEAAIERGLLPFSISTDLHGHSMNFPVWDLATTMSKLLSVNMPFENVIEAVTHNPASVIKLSMENRLSVGQRADFTIFDLVDADLEATDSNGDVSRLNRLFEPRYAVIGAEAITASRYIPRARKLVRHSHGYSWR
Protein: Protein AAR2 homolog (AAR2 splicing factor homolog) (Q9VEA6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pre-mRNA-processing-splicing factor 8
- 116 kDa U5 small nuclear ribonucleoprotein component
- CD2 antigen cytoplasmic tail-binding protein 2 homolog
- Protein ecdysoneless
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- U5 small nuclear ribonucleoprotein TSSC4
- Obelus
- Probable ATP-dependent RNA helicase DDX23
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein Sm D3
Sequence:
MNKDNSSMKMDPQLALRLLADGGVLVIAGVPEGTEFGIDLCAYTIGPDFRGVKMIPPGVHYVWCSSRGPYGDAAPRVGFVHFFHPNEIVVREWDHELEELRPRRIAEPEVERDRIRKNLAQLERVLAPYDYRYVVQWKELTGSVTESCVDRCRPTEGTIRTNIELQSCPDADRPRGGAATVSISRRNAAARILLDESELLPDLKPVEGTAPRFTTVPLRVPQDALPADVSRHALDCIDAVDKLLEGFETADGLIEELQLAYAFFLVGYSVESLAHWRKLLGLLAHSQTAVTKHKLTYMKYSEVLAHQLPHLPEELMVPGPHNTVYKDVRELLVNLHAGGLSVSAERLTKRLEKKLGWEFEGLLDEDPEDQPVVIELPEA
Protein: N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (Q3UIK4)
Organism: Mus musculus (Mouse)
Function: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:24394384, ECO:0000269|PubMed:28914256, ECO:0000269|PubMed:29547716}.
Interaction partners:
- N
- Zinc finger CCCH domain-containing protein 13
- Protein virilizer homolog
- E3 ubiquitin-protein ligase Hakai
- RNA-binding protein 15
- Putative RNA-binding protein 15B
- Pre-mRNA-splicing regulator WTAP
- Microprocessor complex subunit DGCR8
- RNA N
- YTH domain-containing family protein 1
Sequence:
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNSKRKCLDEGETDEDKVEEYKDELEMQQEEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGTHRGGFTPR
Protein: Transcription factor bHLH57 (Basic helix-loop-helix protein 57) (AtbHLH57) (bHLH 57) (Transcription factor EN 12) (bHLH transcription factor bHLH057) (Q9M128)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Short-chain dehydrogenase reductase 4
- Short-chain dehydrogenase reductase 3a
- Transcription factor bHLH19
- Transcription factor bHLH112
- 9-cis-epoxycarotenoid dioxygenase NCED6, chloroplastic
Sequence:
MSGLMSFGELEDQFGQISDTTMEEKIPFLQMLQCIEHPFTTTEPNQFLQSLLQIQTLESKSCLTLETNIKRDPGQTDDPEKDPRTENGAVTVKEKRKRKRTRAPKNKDEVENQRMTHIAVERNRRRQMNEHLNSLRSLMPPSFLQRGDQASIVGGAIDFIKELEQLLQSLEAEKRKDGTDETPKTASCSSSSSLACTNSSISSVSTTSENGFTARFGGGDTTEVEATVIQNHVSLKVRCKRGKRQILKAIVSIEELKLAILHLTISSSFDFVIYSFNLKMEDGCKLGSADEIATAVHQIFEQINGEVMWSNLSRT
Protein: SAM domain-containing protein (Q3UJC0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
METLTATPQTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQNETRDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLITGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLASGSAETLPANFRVTSSMSSPSMQPKKVQMDVYPHYFYR
Protein: Mutant e4 ebony (Q9GSP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGSLPQLSIVKGLQQDFVPRALHRIFEEQQLRHADKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGDFIVAVCMQPSEGLVTTLLAIWKAGGAYLPIDPSFPANRIHHILLEAKPTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQLAGSNLLSEEMLRGGNDHTAIVLYTSGSTGVPKGVRLPHESILQEAYKKQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLENPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAGQVDQAILAFVKLRDDAPMVTETQMEARLKDKLADYMTPQVVILEHVPLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGVIGRSTETTLPPHSNFYELGGNSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQLEEESLNACPHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVLVERDLSFVVYDTNTDRIIGTALNFDARNEPEVDIKSKLLIVFEFLEFCEGPIRDNYLPKGLNQILHSFMMGTAEKLNPRENIACMHFMEHEVLRVAREKQFAGIFTTNTSPLTQQLADVYHYKTLLNFQVNEYVHSDGSRPFGDAPDEQRAIVHWKEVGK
Protein: Tektin-4 (Q2TA38)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Contributes to normal sperm motility (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}. Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. {ECO:0000269|PubMed:37327785}.
Interaction partners:
- Tektin-1
- Protein Flattop
- Tektin-2
- EF-hand domain-containing protein 1
- Cilia- and flagella-associated protein 52
- Adenylate kinase 8
- Outer dynein arm-docking complex subunit 2
- Piercer of microtubule wall 1 protein
- Tektin-3
- Outer dynein arm-docking complex subunit 4
Sequence:
MAQTDILLTKEPAPQTVPACQLPRKLYDVARNTGAHTSSGLATSGFRTAKYLLDEWFQNCYARYHQAFADRDQSERQRHESQQLAAETEALAQRTQQDSTRKVGERLQDMHGWKSELQRQVEELVSETELLLAQKQRLERALDATAGPFSIVTDNLQCRERRQHPDLVRDCVEIELLKEAELIRNIQELLKRTIKQAVSQIRLNWEHKETCEMDWSDKVEAYNIDEACCRYNNQSTDVQFYPHSAKFEESASTPETWAKFTQEHLYRAERERLASVNLRNLIDCILQDTSEDLRLQCDAVNLAFGRRCEELEDARHKLEHHLRKTLREISDQEHNIAALKQAIKDKEAPLKVAQTRLYQRSHRPNVELCRDAAQFRLASEVEELNLSLAALKEKLLEAEQSLRNLEDTRMSLEKDIAIKTNSLFIDRHKCMAHRAHYPTVLQLAGYQ