wanglab/gogpt-training-data huggingface dataset:
Protein: Pollen-specific leucine-rich repeat extensin-like protein 4 (AtPEX4) (Pollen-specific LRR/EXTENSIN4) (Cell wall hydroxyproline-rich glycoprotein) (O81765)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization.
Subcellular location: Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Protein RALF-like 19
- Probable receptor-like protein kinase At2g21480
- Protein RALF-like 4
- GPI-anchored protein LLG3
- GPI-anchored protein LLG2
- Receptor-like protein kinase FERONIA
Sequence:
MPFYKQPWVFSKVFVLAMAKPPSFGCCFFLLFFSFLSSSFVSFALTDTEAAFIVQRQLLTLPDNGELPDDIEYEVDLKATFANTRLKRAYIALQAWKKAIFSDPFNTTGNWHGPHVCGYTGVVCAPALDDSDVTVVAGVDLNGADIAGHLPAELGLMTDVAMFHLNSNRFCGIIPKSFEKLKLMHEFDVSNNRFVGPFPNVVLSWPDVKYFDLRFNDFEGQVPPELFKKELDAIFLNDNRFTSVIPESLGESPASVVTFANNKFTGCIPKSIGNMKNLNEIVFMDNDLGGCFPSEIGKLSNVTVFDASKNSFIGRLPTSFVGLTSVEEIDISGNKLTGLVPHNICQLPNLVNLTYSYNYFSGQGGSCVPGGSRKEIALDDTRNCLASRPEQRSAQECAVVINRPVDCSKDKCAGGSSTPSKPSPVHKPTPVPTTPVHKPTPVPTTPVQKPSPVPTTPVQKPSPVPTTPVHEPSPVLATPVDKPSPVPSRPVQKPQPPKESPQPDDPYDQSPVTKRRSPPPAPVNSPPPPVYSPPPPPPPVHSPPPPVHSPPPPPVYSPPPPPPPVHSPPPPVFSPPPPVYSPPPPVHSPPPPVHSPPPPAPVHSPPPPVHSPPPPPPVYSPPPPVFSPPPSQSPPVVYSPPPRPPKINSPPVQSPPPAPVEKKETPPAHAPAPSDDEFIIPPFIGHQYASPPPPMFAGY
Protein: L71-3 (Q24073)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKITLIFAILCLCMAVQAQTREQEICRQENETCRRNERRLGVQNDVSTTFNNHCRRQSGIRNWRNVSRCELSLATCRLTLERCAVINCKNVRNSIDGGVTARPPTSRRTTRRIPDTRRPRTTRRTPTTRRAPTTRSSRRTTRRRAPTTRTTRRTTRRRAPTTRTTTRRPTEE
Protein: Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Q6P3K2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MERLEKPKKERLRVCVATCNRADYSKLAPIMFGIKSHPDIFDLEVVVLGSHLIDDYGNTFRMIEQDDFDIGSKLHTIVRGEDEAAMVESVGLALVKLPDVLQRLAPDILLVHGDRFDALALATAAALMNIRILHLEGGEVSGTIDDSIRHAISKLAHYHAVCTLSAERHLISMCEDHSRILLAGCPSYDKLLSAYKRDDYADIIKSWIGDDVKEQDYIVALQHPVTTDIKNSIKIYELMLDALISFNKKTLILFPNIDAGSKEMVRVMRRKGIEQHQNFRAVKHVPFDQFIQLVAHAVCMIGNSSCGVREAGAFGTPVINLGTRQTGRETGENVLHVRDADTHNKIYHALELQFGKRYPCSKIYGDGNAVQRILKFLQTIDLSEPLQKKFCFPPVKECISQDIDHILETQSALSVDLGGTNLRVGIVSMKGKVVKKYVQLNPKTFEERIELILTMCKQAMADAVHLNCRILGVGVSTGGRVNPQDGVVLHSTKLIKEWSSVDIRTPLSSALHLPVWVDNDGNCAALAERKFGHGKGVENFVTIITGTGIGGGIIQHNELIHGNTFCAAELGHIVVSLEGPECMCGGHGCIEAYSSGLALQREAKRLHDEDLLLVEGMTLNNKEQVNAIHLINAARLGNSKAETVLHTAGTALGLGIVNILHMINPSLVILSGVLAVHYETPVRQVIGQRALLTAQGTKVMVSDLEDPALLGAASMVLDYTTRRTY
Protein: Centrosomal protein 112 (A0A8I6GHB3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEMGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRSERQRCALWIRKLCEPSGTGAGLMGRKNRNLYAKLLLHMLRRGVLEGPFTHRPEPGTLKVLPSYMSIYFDEPNSAQSKDSSPEKLPDWVMGELEPGERRLSDSWQLSCGEENALLLSASDAHRKFIQKSLLFLWMTVTLKFA
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FMJ6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MILHRLLLLLNLDWNREVEMTVQDLDVRALPGYFKGYSARDTPETRHNATELDFLAFDDQFTTWKQLYQAIPKDTDTHSYKLLVLARHGEGYHNAAEARYGEKAWNEYWSKLEGDQYGSWLDAELTPLGKKQALEAGQTYLTNLTDGLQLLPHKFFVSPMRRCLDTYIREWEPVFSTHRPSNATVNVKVIEYLRETLGVHTCDERVSHSQALSEYQDHRYNNSDVTVHFDYPGNYSEKDQLWYPDHRETKAEMDRRTRIGLREMFSSVNTTDKVISLTCHSGVIASVLRNIKHPAIDHLQTGKLVYAVVELSKAPTDDQPMLVVS
Protein: Contig An01c0440, genomic contig (A2QB23)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MLSFLLWCHPKKRKERQLWKQIEEEAEHLDQLPSWDAPDNTLMLQAFEWHVPADQGHWRRLHQALPNFKAIGVDNIWIPPGCKAMNPSGNGYDIYDLYDLGEFEQKGSRATKWGTKEELQSLVAAAQDFGIGIYWDAVLNHKAGADYAERFQAVRVDPQERNMKIAPAEEIEGWVGFNFSGRGNHYSSMKYNKNHFSGIDWDQSRQKCGVYKIQGHEWANDVANENGNYDYLMFANLDYSNAEVRRDVLKWAEWLNAQLPLSGMRLDAVKHYSAGFQKELIDHLRTIAGPDYFIVGEYWKGETKPLVDYLKQMDYKLSLFDSALVGRFSSISQTPGADLRNIFYNTLVQLYPDHSVVQYALWPHSTNIDPKQPGQSLEAPVTSFFKPLAYALILLRDQGQPCIFYGDLYGLQADVKDPMTPSCRGKLSILTRARKLYAYGLQRDYFDKPNCIGFVRYGNRRHPSGLACVMSNAGPSRKRMYVGRRHAKQTWTDILQWCDQTVVIDAKGYGEFPVSAMSVSVWVNSEAEGRDSLSHHLYVPAHSLSTDDLLTSAEISDENIYKLA
Protein: Myb-binding protein 1A (PAR-interacting protein) (PIP) (O35821)
Organism: Rattus norvegicus (Rat)
Function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q7TPV4}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q7TPV4}. Cytoplasm {ECO:0000250|UniProtKB:Q7TPV4}. Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1. {ECO:0000250|UniProtKB:Q7TPV4}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- KRR1 small subunit processome component
- HEAT repeat-containing protein 1
- DNA-directed RNA polymerase I subunit RPA1
- DNA-directed RNA polymerase I subunit RPA2
- Nucleolar RNA helicase 2
- Protein RRP5 homolog
- Nucleolar protein 6
- Periodic tryptophan protein 2 homolog
- Pescadillo homolog
Sequence:
MAEMKSPTKAEPASPAEAPQGDRRSLLEHSREFLDFFWDIAKPDQETRLRATEKLLEYLRTRPSDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIQLCDILGQIQEKYNLQAMNKAMMRPTLFANLFGVLALFQSGRLVKDKEALMKCVRLLKILSHHYNHLQGQPVKALVDILSEVPESMFQEILPKVLKGDMKVILSSPKYLELFLLARQRVPAELESLVGSVDLFSEDNIPSLVNILKVAANSVKKEQKLPDVALNLLRLALQENKFERFWKEVLEEGLLKKPSYTSSYMCFRLLGASLPLLSDEQLQLVMRGDLIRHFGEHMVVSKSQNPLRFIPEISAYVGTFLEGCQDDPKRQFTVMVAFTAITNQGLPVMPTFWRVTRFLNTEALQNYVTWLRDMFLQPDLDSLVDFSTANQKRVQVASLNVPERTVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKTKKATPQIPETKQHFSFPLEDGNRGVIVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADMLLKHNRNVANVTPLTAQQRQAWDQMMSTLKELEAQSSETRAIAFQHLLLLVGLHLFKSPAESCDVLGDIQTCIKKSMEQNLRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHVCSHLTPRGLQLILAVLNPETNEDEEDNVVVTDTDEKQLKHGEDADSDSEDSKNSESDVDSEDGEESEEEDRDKDVDPGFRQQLMEVLQAGNALGGEEEEEEELGDEAMMALDQNLASLFAEQKMRIQARHEEKNKLQKEKQLRRDFQIRALDLIEVLVTKQPEHPLILELLEPLLNIIQRSMRSRGSTKQEQDLLHKTARIFMHHLCRARHYCHEVEPGAEALHAQVERLVQQAGNQADASVALYYFNASLYLLRVLKGNTTKRYQDGQKLEGADIKSEPKDSEVQTTSCLDLDFVTRVYSASLESLLTKRNSPLTIPMFLDLFSRYPVICKNLLPIVVQHVAGSSRPRHQAQACLLLQKALSARELRVCFEDPEWEQLISQVLGKTTQTLQTLGEAQSKGEHQRELSILELLNTVFRIVNHEKLSVDLTAFLGMLQGKQQKLQQNLQQGNHSSGSSRLYDLYWQAMNLLGVQRPKSEKKNVKDIPSDSQSPISTKRKKKGFLPETKKRKKLKSEGTTSEKKAASQQDAVTEGAMPAATGKDQPPSTGKKRRKRVKANTPSQVNGVTVAKSPAPNNPTLSPSTPPAKTPKVQKKKEKLSQVNGSTPVSPVEPESKKHQKALSTKEVKRRSSQSALPKKRARLSLVSRSPSLLQSGIRKRRVARRRVQTP
Protein: Ferric/cupric reductase transmembrane component 1 (EC 1.16.1.9) (Ferric-chelate reductase 1) (P32791)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1431884, ECO:0000269|PubMed:15288128, ECO:0000269|PubMed:17507646, ECO:0000269|PubMed:8662826}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Plasma membrane iron permease
- Probable ferric reductase transmembrane component 8
- Metal-binding activator 1
- Iron transport multicopper oxidase FET3
- Iron-regulated transcriptional activator AFT1
- Low-affinity Fe
- Copper transport protein CTR3
- Copper-transporting ATPase
- Ferric/cupric reductase transmembrane component 2
- Siderophore iron transporter ARN1
Sequence:
MVRTRVLFCLFISFFATVQSSATLISTSCISQAALYQFGCSSKSKSCYCKNINWLGSVTACAYENSKSNKTLDSALMKLASQCSSIKVYTLEDMKNIYLNASNYLRAPEKSDKKTVVSQPLMANETAYHYYYEENYGIHLNLMRSQWCAWGLVFFWVAVLTAATILNILKRVFGKNIMANSVKKSLIYPSVYKDYNERTFYLWKRLPFNFTTRGKGLVVLIFVILTILSLSFGHNIKLPHPYDRPRWRRSMAFVSRRADLMAIALFPVVYLFGIRNNPFIPITGLSFSTFNFYHKWSAYVCFMLAVVHSIVMTASGVKRGVFQSLVRKFYFRWGIVATILMSIIIFQSEKVFRNRGYEIFLLIHKAMNIMFIIAMYYHCHTLGWMGWIWSMAGILCFDRFCRIVRIIMNGGLKTATLSTTDDSNVIKISVKKPKFFKYQVGAFAYMYFLSPKSAWFYSFQSHPFTVLSERHRDPNNPDQLTMYVKANKGITRVLLSKVLSAPNHTVDCKIFLEGPYGVTVPHIAKLKRNLVGVAAGLGVAAIYPHFVECLRLPSTDQLQHKFYWIVNDLSHLKWFENELQWLKEKSCEVSVIYTGSSVEDTNSDESTKGFDDKEESEITVECLNKRPDLKELVRSEIKLSELENNNITFYSCGPATFNDDFRNAVVQGIDSSLKIDVELEEESFTW
Protein: CAMPATH-1 antigen (Lymphocyte differentiation antigen B7) (CD antigen CD52) (Q64389)
Organism: Mus musculus (Mouse)
Function: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Sialic acid-binding Ig-like lectin 10
- CD48 antigen
- T-cell surface glycoprotein CD3 epsilon chain
- Leukocyte surface antigen CD53
- Receptor-type tyrosine-protein phosphatase C
- H-2 class II histocompatibility antigen gamma chain
- TYRO protein tyrosine kinase-binding protein
Sequence:
MKSFLLFLTIILLVVIQIQTGSLGQATTAASGTNKNSTSTKKTPLKSGASSIIDAGACSFLFFANTLMCLFYLS
Protein: RRM domain-containing protein (Q95QI9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSGARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEKRGNSNNAARSGGGGGGNRGGAERGIAPAQQPYDNNGGHRSGGGGGRSGGGGTSFNGAAFTESQLMDEVPKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLSGKGFAFLRLISNAANKS
Protein: Adapter molecule crk (Q6DEM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Paxillin
- Paxillin
- Breast cancer anti-estrogen resistance protein 1
- Rap guanine nucleotide exchange factor
- CRK SH3-binding GNRP
- Dedicator of cytokinesis 1
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Epidermal growth factor receptor precursor.
- Protein tyrosine kinase 2ab
Sequence:
MAGNFDSEDRGSWYWGRLSRQEAVSLLQGQRHGVFLVRDSITIPGDYVLSVSENSKVSHYIINSISSNRQSGPGLAPPRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPISKSKHSSFISVNAGTGGAPPRLEEEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRVGMIPVPYVEKYRPASPTSGAPGVSVSGSGAHGNSDGHSTQSPPLLGEPGQYAQPTSLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVKVTKINVNGQWEGECKGKHGHFPFTHVRLLDQHNPEDELS
Protein: Glutathione-independent glyoxalase HSP31 (EC 4.2.1.130) (Glyoxalase 3 homolog 1) (Heat shock protein 31) (Q04432)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:24706893}. Note=Present in processing bodies (P-bodies) and stress granule (SG) foci upon glucose starvation and heat shock. {ECO:0000269|PubMed:24706893}.
Interaction partners:
- Glyoxalase I
- Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
- Hydroxyacylglutathione hydrolase, mitochondrial
- NADPH-dependent methylglyoxal reductase GRE2
- D-lactate dehydrogenase [cytochrome] 1, mitochondrial
- D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2
- D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3
- D-serine dehydratase
- Threonine dehydratase, mitochondrial
- Catabolic L-serine/threonine dehydratase
Sequence:
MAPKKVLLALTSYNDVFYSDGAKTGVFVVEALHPFNTFRKEGFEVDFVSETGKFGWDEHSLAKDFLNGQDETDFKNKDSDFNKTLAKIKTPKEVNADDYQIFFASAGHGTLFDYPKAKDLQDIASEIYANGGVVAAVCHGPAIFDGLTDKKTGRPLIEGKSITGFTDVGETILGVDSILKAKNLATVEDVAKKYGAKYLAPVGPWDDYSITDGRLVTGVNPASAHSTAVRSIDALKN
Protein: Uncharacterized protein C16orf78 (Q8WTQ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSEQQMDLKDLMPTKRKYMWKTAEDRRMSDLTCVLEWLERRQGKKKQAPEKQKPKVVTVLKRNKKKEEKKGKGLMTARGGNRRDTETSQQALGKRFRKDAASYRSLYGVEQKGKHLSMVPGSYIKDGPKKSDTDIKDAVDPESTQRPNPFRRQSIVLDPMLQEGTFNSQRATFIRDWSNKMPDMAYERKLKSLMEKSTEPKMETMRMLKPEEVLSCRYLRLSKENIRTLLKLCKDAGMNVDIHPHMVEEDIDAKKVFTGIPSMAL
Protein: Uncharacterized protein (A0A384KCV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTSLLLLRTLPLLRNGFLNHRHQVGIVAGGILSHRRRLLCSLADRPQFYENNDSVSPVEGSGAAAMNVTSPVVDNSWRYEDPDYRKWKNLEAEILRDIEPISLLAKEILHSDRYLDGERLDFEDEKIVMEKLLPYHPYSKDKIGCGLDFIMVDRHPQFRHSRCLFVVRTDGGWIDFSYQKCLRAYVRDKYPSHAERFIREHFKRASS
Protein: Uncharacterized protein (Q8IRI8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSIRLVALLALFAALAHGKPGYGPGEQDWGYVDVRPGAHMFYWLYYTTANVSSYTERPLAIWLQGGPGASSTGYGNFEELGPVDLYGDWRSWTWVKDMNVLFIDNPVGSGFSYVDNTAFYTATNKEIALDLVELMKGFYTLHPEFEEVPLHIFCESYGGKMAPEFALELYYAKKRGEVKSNLTSVALGDPWTSPIDSVLAWGPFLREMGIVDHAGYNAIQEAANFTAQLVEEERWIQATYQWGNTQWEVMKASKGVDFYNVLKETKGGLYQRSKALTSEERLYRTMVKYDIDEDRTKLLEDLMRGPVAETLGIPSNVIWGSQSGTTFDIHRTDFMKPVIHIVNELLEKTPLKVGVFSGGLDLICATPGTVNWIAKLDWSRKDEYLAAPRNGITVDRILEGYQKTGGNFTMFWINRSGHMAPADNPAAMSHVLREFTSFG
Protein: Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (An4a) (Nucleoporin Nup93) (Q7ZX96)
Organism: Xenopus laevis (African clawed frog)
Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
Subcellular location: Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. {ECO:0000250}.
Interaction partners:
Sequence:
MDGEGFGELLQQAEQLAAETEGVTELPHVERNLQEIQQAGERLRSKTMTRTSQESANVKASVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFVMAEEYHRESMLVEWEQVKQRVLHTLLASGEDALDFTQESETSYISESGAPGRSSLDNVEMAYARQMYMYNEKVVSGHLQPSLVDLCTEAAERLDDKNVSDLWVMVKQMTDVPLIPASDTLKSRCSGQMQMAFVRQALNYLEQSYKNYTLISVFANLQQAQLGGVPGTYNLVRSFLNIRLPTPIPGLQDGEIEGYPVWALIYYCMRCGDLMAAQQVVNRAQHQLGDFKNCFQEYIHNKDRRLSPTTENKLRLHYRRAVRASTDPYKRAVYCIIGRCDVSDNHSEVADKTEDYLWLKLSQVCFEDEANSSPQDRLTLPQFQKQLFEDYGESHFAVNQQPYLYFQVLFLTAQFEAAIAFLFRLERTRCHAVHVALALFELKLLLKSTGQSAQLLSQEPGEPQGVRRLNFIRLLMLYTRKFEPTDPREALQYFYFLRNEKDNQGESMFLRCVSELVIESREFDMLLGKLEKDGSRKPGAIDKFTRDTKTIINKVASVAENKGLFEEAAKLYDLAKNPDKVLELTNKLLSPVVSQISAPQSNRERLKNMALAIAERYKSQGVSAEKSINSTFYLLLDLITFFDEYHAGHIDLSFDVIERLKLVPLSQDSVEERVAAFRNFSDEIRHNLSEILLATMNILFTQYKRLKGSGPTTLGRPQRVQEDKDSVLRSQARALITFAGMIPYRMSGDTNARLVQMEVLMN
Protein: Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (EC 3.1.3.16) (Q9Y0B7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for development, chemotaxis and the expression of numerous genes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17353263}. Nucleus {ECO:0000269|PubMed:17353263}. Note=Translocated to the nucleus in aggregation-competent cells, probably by smkA.
Interaction partners:
- Suppressor of Mek1
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- Uncharacterized protein
- Serine/threonine-protein phosphatase 2A catalytic subunit A
- TAP42-like family protein
- Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB
- Protein phosphatase 2A scaffold subunit
- Serine/threonine-protein phosphatase 2A regulatory subunit psrA
- Probable serine/threonine-protein phosphatase 2A activator 1
- Probable serine/threonine-protein kinase roco6
Sequence:
MSSDLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIPGWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQESRGAPAKKPAPEYFL
Protein: Protein Daple (xDaple) (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues-like) (xDal) (P85120)
Organism: Xenopus laevis (African clawed frog)
Function: Positive regulator of Wnt signaling, acting synergistically with dvl2/dsh. Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9P219}. Cell junction {ECO:0000269|PubMed:30948426}. Note=Enriched at apical cell junctions. {ECO:0000269|PubMed:30948426}.
Interaction partners:
Sequence:
MDTTISQQMDHFLESPLVTWVKTFGPCGNENESKLAMYMELVDGVFLNKIMVQIDPRPSNQRVNKHVNNDVNRRVQNLTILVRHIKAYYQEVLQQLIVMNLPNVLLISKDPLTDKSMEELKKILLLMLGCAVQCERKEEYIERIKQLDIETQAGIVSHIQEVTHNQENVFDLQWLELSDMAPEELDSLSRNMALHLKRLIDERDECKEVIVDLTQERDYLQFQNHPSPVKSSSPDTSANMVSHLSSEDKKHLAVELAESKAKLRRIRQELEEKSELLLDTKHEVERLNLELQKIKQENFQLASEARTARTYRDEIDSLKERASKVDRLENELARCKEKLHDVDFYKARMDELREDNMILIETKSMLEEQLAAARTRTDKLHELEKENLQLKSKIHDLELDRYSDKNRIEELLEENMVLEIAQKQSMNESAQLGWELDQLSKSTDLSDARKSFVFELNETTSSKILKLEKENQSLQNIIQDLREASLTLEEGNLKGQEWEKENQQLSKKIENLNQQIERERQSSLDLESLSEDLLKEKDQLSQALENIKSQKERQIKELEQENKHLIQTLEAVRQRSQVSTEARVKDIEMENRILHETIKDTSSKMNELEYEKKQLQKAFDQSKEQVEKLDKMEKEVHRLEKQNEILTKKVTSIKIVEEKMQGLEKENEVLEGENIVLKKSLDTLQNVTIKLEVLESENKQLDEENLELRRAVEAMRFSCAKSTQIERENNELQKEKEELQKNVELLKALGKKSERLEVSYQGLNDENWRLQQMLDTGNKKINDLEKELHDTEKENKDLQRTLEEMKICNKRLERMEEENKAKEQEMVQLEKDNKILQKESKRLWQQVELKDAILDDNTVKLADLEKENRALEKEISKLRDLSTKTRDLERENKDLLQQMTVDKRTLATLREDLVLEKLKTQQMSSELDKLSLELEKIGLNKESMLQDENSNAEKKYKLLENKIESTLKTTLAVKENKIVALEMKIEETSSLNQQLQNELNSIKKDIIASKENLRGAAHNSYTQLSSKQDCNSQINGQRETTVELLKFKDRTIELERNNAALQAEKKLFREQLQHLESHNLNLSSQMGTLQKQVTFLQEHNTALQTQTANLQVENATATSQVASLKSQISQFQNQLSARESENEILQQQKEHLRVTHESLLQDHEQLGSLYERQSAEYEGMISQHSSLKSQYKSLEQAHRSLEESYSTLIKHKKELEDLDAVLKKEQDVLQQERRKNFVAMEENQKLKTDLERLNFLHGELQTEYSSLHKHTKEVKTSLNNAQMELNRWQARFDELKEQHQTMDISLTKLDNHCELLTRLKSNLEEENHHLLSQIQMLSQQNQMLLEQSMETKEQYHEEQKQYIDKLHDLRRQKEKLEEKIMDQYKFYDPTPKKKSHWSGAKAIAKLIKPKKEPSRESVKSPTDVQSKTMDNAEMAASPSSMRPLRLQQESLDNSSLGSDEKGSPKVLASKVLVEVAQRQHRMSYHGSSSEQTDGPEHLSRSRRMESGSRAFSTSTIHLTAPAHNAKVPHLSRPKGYNSDDNQSDQLHEAESNAGSSRVPWTSSLEVSRSASNSSSPLTLKGRPESVSSEDMIPTKDIATLSRESNLYHPNAVMLGATKNRESPVNRNSLHLYDYPEKKNSSRTPTRPRPGSPGSEMVTLEEFLQESSRQSPPSRRHSLNDSELITLHQFLFEAETLHPSSQSPSPTLHLKDPSQTAVPKSLPSAENCEWRKRADRASRRAASLYIPRDMVTNRDDMLGDLFKKTEDPPDIRSPMSELIFKDAAQMPTSYVSPTVKVTGNTTKPGQYVKPHPRQLDAPLNVTSSLLHQANVYSATSSSQSPEPQALSPHGAMGSRGNSLSRAFSLASADLLKENGPEVVMQEKSDVETPVGKDFGRYMIRSSTPLGSQSSLREKPQSARMQHMLRGDDRQYRSLDSRRLSLALPKEETTPPQPAPSASSLQQHYTLGHGAIRGKPKLLSRSGEVALVSPVRPISSIPELETTQGLASAGPGKSRSTSPDCSPAPVCEEEPNKSETLKSTPASPDPSADPQTVWYEYGCV
Protein: Protein PBDC1 homolog (Q08971)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Altered inheritance rate of mitochondria protein 29
- Alpha-factor-transporting ATPase
- Protein HGH1
Sequence:
MSTFNAETADNLEDIEKQFAVVAVEQAETYWKLLTSVPGSKLRLTKFDDEIYENFMERFPEYKDVERVKKFTEEELKTKEAKERWRKFFTIFEKKIEDYNFGTLLRTDASAEYGQFTTCFVVRLQFYAFEIARNKHGLNDWIVGQK
Protein: Pre-rRNA-processing protein esf2 (18S rRNA factor 2) (O74362)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-rRNA-processing protein esf1
- ATP-dependent RNA helicase dbp4
- U3 small nucleolar RNA-associated protein 6
- rRNA biogenesis protein rrp36
- ATP-dependent RNA helicase dbp8
- Uncharacterized protein C13G1.09
- U3 small nucleolar RNA-associated protein 25
- KRR1 small subunit processome component homolog
- Probable nucleolar complex protein 14
- Uncharacterized protein C18B11.06
Sequence:
MSTAEQLFGAEEEEKYVDQDLSEDEEDERFLKAIRSSRSTKPVVDVLKVKSESSADELEERDAHLDRFRRDSTFESETSDHEDFSGGSENELDEETTKNANSIKKISLEEVEKQRKAIKRSGVIYLSRIPPYMAPNKLRQILSQYGKIGRVYLTPESSAKRAQRLRNGGNKRVMYEEGWIEFESKRVAKSVAELLNTNQIGGKKSSWYHDDIWNMKYLPKFKWHHLTEQIAAENAARESRLKVEIEQGRKQLKQYMRNVENAKMIEGIRKKRSERDTLNVSTEFPEETKDLSEDTKPSKQARRFFGQKSIVSNRNMPTDNAKQQKVENVLRRVF
Protein: Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2) (P55289)
Organism: Homo sapiens (Human)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Cadherin-8
- Catenin beta-1
- Catenin alpha-1
- Cadherin-24
- Catenin alpha-2
- Cadherin-9
- Cadherin-2
- Cadherin-18
- Cadherin-15
- Cadherin-7
Sequence:
MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEESYNPDKVT
Protein: 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Sterol Delta(7)-reductase) (Q7SXF1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBM7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sterol-C5-desaturase
- 24-dehydrocholesterol reductase.
- Lanosterol 14-alpha demethylase
- NAD
- Ergosterol biosynthesis 28 homolog
- Cholesterol 25-hydroxylase-like protein
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Terpene cyclase/mutase family member
- Squalene epoxidase a.
- Cholesterol 7-alpha-monooxygenase
Sequence:
MMASDRVRKRHKGSANGAQTVEKEPSKEPAQWGRAWEVDWFSLSGVILLLCFAPFLVSFFIMACDQYQCSISHPLLDLYNGDATLFTIWNRAPSFTWAAAKIYAIWVTFQVVLYMCVPDFLHKILPGYVGGVQDGARTPAGLINKYEVNGLQCWLITHVLWVLNAQHFHWFSPTIIIDNWIPLLWCTNILGYAVSTFAFIKAYLFPTNPEDCKFTGNMFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGYVTNSMILVNVLQAVYVVDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPFLYTLQGLYLVYNPIQLSTPHAAGVLILGLVGYYIFRVTNHQKDLFRRTEGNCSIWGKKPTFIECSYQSADGAIHKSKLMTSGFWGVARHMNYTGDLMGSLAYCLACGGNHLLPYFYIIYMTILLVHRCIRDEHRCSNKYGKDWERYTAAVSYRLLPNIF
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (B3DJG0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRQLLFITVVLTGVCLLLTLCSGGQNPDHVLQGTGVKLDSRRPGDDSTIAPEDAARFLSCHCSGHCPDDAKNNTCETNGQCFAIIEEDENGDVILSSGCMKYEGSHFQCKDSQFAQTRRTIECCQFDFCNQDLKPELPPRDSEPPDPHWLAFLISVTVCFCALICVTVICYYRYKWQTERQRYHRDLEQDEAFIPAGESLKDLINQSQTSGSGSGLPLLVQRTIAKQIQTVRMIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADINGTGASTQLYLITDYHENGSLYDYLKFTTLDTQALLRLAFSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDLPLSTRMGTRRYMAPEVLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVTGGIVEEYQLPYYEMVPSDPSYEDMLEVVCVKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTLAKMVESQDIKI