wanglab/gogpt-training-data huggingface dataset:
Protein: Ribonuclease P protein subunit p20 (RNaseP protein p20) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7) (O75817)
Organism: Homo sapiens (Human)
Function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14715275, ECO:0000269|PubMed:20215441}. Cytoplasm {ECO:0000269|PubMed:14715275}. Cytoplasmic granule {ECO:0000269|PubMed:14715275}. Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules. {ECO:0000269|PubMed:14715275}.
Interaction partners:
- Ribonuclease P protein subunit p30
- Ribonuclease P protein subunit p25
- Ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p29
- Ribonuclease P protein subunit p38
- Ribonuclease P protein subunit p40
- Ribonucleases P/MRP protein subunit POP1
- Ribonuclease P protein subunit p21
- Ribonuclease P protein subunit p14
- Ribonuclease P protein subunit p25-like protein
Sequence:
MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNSAIHIRVFRVTPK
Protein: Acetylcholine receptor subunit beta (P02712)
Organism: Tetronarce californica (Pacific electric ray) (Torpedo californica)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLTLTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNNDGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEVTLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRKPLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPVTTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVTLPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFLDASHNVPPDNPFA
Protein: Semaphorin-4G (Q9WUH7)
Organism: Mus musculus (Mouse)
Function: Cell surface receptor for PLXNB2. May play a role in axon guidance.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Plexin-B2
- Plexin-B1
- Plexin-B3
Sequence:
MWGRLWPLLFSFLTVTAVPGPSLRRPSRELDATPRLTISYEELSQIRHFKGQTQNYSTLLLEEASERLLVGARGALFSLSARDIRDRTHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNATHFYACGTHAFQPLCAAIDAETFILPTSFEEGKEKCPYDPARGFTGLIIDGGLYTATRYEFRSIPDIRRSRHPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSAVGDDDKIYFFFMEREEGSSSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIPQYETLRGVCSLNADTSSHTHFYAVFTLTTQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRWGRYEGGVPEPRPGSCITDSLRSRGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNVRYTHLTGTHVSTPAGPTYDLLFLGTADGWIHKAVVLGSGMHIIEEIQVFREPQSVDNLVISPMQHSLYVGAASGVLQFPLSSCSRYQSCYDCILARDPYCGWDSSIHACMVATTVANRTELIQDIERGNRGCEGSRDAGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSKSLSDGQDGYRVGVDGLLVTDTQLEHSGNYGCYAEENGLRMLLASYSLTVRPATPAPAPQAPATPGAQLAHDMRMFYVVAIAILGGLCLILASSLLYVACLKGGRRGRRRKYSLGRAGRAGGSAVQLQTVSGQCPGEEDEGDDGEGTGGLESGCLQIIPGEGAPAPPPPPPPPPPAELTNGLVALPSRLRRMNGNSYVLLRQSNNGVPAGPCSFAEELSRILEKRKHTQLVEQLDESSV
Protein: Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) (P43699)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P50220}.
Interaction partners:
- Paired box protein Pax-8
- Thyrotropin receptor
- Forkhead box protein E1
- Pulmonary surfactant-associated protein B
- Thyroglobulin
- Hepatocyte nuclear factor 3-alpha
- Mothers against decapentaplegic homolog 3
- Napsin-A
- Transcription factor GATA-6
- Keratin, type II cytoskeletal 7
Sequence:
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW
Protein: HTH-type transcriptional regulator LeuO (P10151)
Organism: Escherichia coli (strain K12)
Function: A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent.
Interaction partners:
- Transcriptional activator protein BglJ
- CRISPR system Cascade subunit CasA
- Putative transcription factor YjjQ
- DNA-binding transcriptional dual regulator CRP
Sequence:
MPEVQTDHPETAELSKPQLRMVDLNLLTVFDAVMQEQNITRAAHVLGMSQPAVSNAVARLKVMFNDELFVRYGRGIQPTARAFQLFGSVRQALQLVQNELPGSGFEPASSERVFHLCVCSPLDSILTSQIYNHIEQIAPNIHVMFKSSLNQNTEHQLRYQETEFVISYEDFHRPEFTSVPLFKDEMVLVASKNHPTIKGPLLKHDVYNEQHAAVSLDRFASFSQPWYDTVDKQASIAYQGMAMMSVLSVVSQTHLVAIAPRWLAEEFAESLELQVLPLPLKQNSRTCYLSWHEAAGRDKGHQWMEEQLVSICKR
Protein: Protein S40-5 (AtS40-5) (Q9SAA7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20238146}.
Interaction partners:
Sequence:
MARGRKLTMSQSERYLGSSYSYGDSNGNSATDESELTEEDIWSHAVDHSPEMLESHGAWNTRDAVVRNGRVGGGLSLAFEDASSSPRIVHQIRGGGEGGGGGGGGGRVERQLASSAPVNVPDWSKIYRVNSVESIHESDEEEEEDSGMMMPPHEYLAKSQQRRSRKSGGGGSVFEGVGRTLKGRELRRVRDAIWSQTGFYG
Protein: Wilms tumor 1-KTS isoform (A9CSE8)
Organism: Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MGSDVRDMNTLLPPVSSLAGNSSCNVPVNSSAQWAPVLDFPPGAPYTSLAPHSFIKQEPAWNPDLHEDQCLSAFTVHFSGQFTGTAGACRYGAFGAPPPSQAFKGQPRMFPNSPYLPKCLENQQGIRNQGYSAMVFDGTPSYGHTPSHHTAQFPNHSFKHEDPITQQSSLGDQQYSVPPPVYGCHTPTDSCTGSQALLLRSPYNSDNLYQMTSQLECMTWNQMNLSSSLKGHGTTYENDSHSTPMLYSCGGQYRIHTHGVFRGLQDVRRVPGVTPAIVRSSTETNEKRPFMCAYPGCNKRYLKLSHLQMHSRKHTGEKPYQCDLKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Protein: Paired box 2 (A0A0A0MRH7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH
Protein: EWS RNA-binding protein 1a (A0A0B4J1A5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein M
- TAR DNA-binding protein 43
- DNA-dependent metalloprotease SPRTN
- DEAH
Sequence:
MASAADYNSYGQAGSQQGYGSYPAQPSQPGYGQGTQQSYGQQQGYGSYSQPADSTYSQTSGSSSSYGQQPYGSSYGQQPPASGSYNAASATPQGYTQPVQGYGSSSYDSSTAAASSTSNTQTSYGGQASYGTQSAYPGYGQQPAAAAPPSSYSSGSQQPAGYEQSSYSQQPQQSTYSQQQQGGYQGQQGGYGQQSSYSQQGGYQQTPPQQQQAPPSSYAPPSGSYGQPSASQYGQQGSTGGGYGQSDYKPPNQYGSYRPDHQNGGGYSGPESGGYGGPGEGRGMGGGENRGRGRGGFDRGMMRGGGGMRGGMSRGGMGIAGDRGGFSKPGDGEMGAPEEQDDSENSTIYITGLTENATLEEVADFFKHSGIIRINKRTGLPAVNIYTDKDTGKPKGDATLSYEEPPSAKAAVEWFDGKDFQGKKLKVSMARRKPMMGMMRGGMPMRGDRGGMMGRGGMMGRGGMGRGGDRGGFMPRGGPRGMGRGGPTGGNMQQRAGDWQCPNAGCGNQNFAWRMECNQCKAPKPEGFGPPPFPPGGDRGRGGPGGMRGGRGMDRGGPGGPGGFRGGRGVDRGGFRGRGMDRGGFGGRGRGGPPMDDMGRRGRGMGPPGKMDMKGDHRQDRRERPY
Protein: Nuclear protein localization protein 4 (HMG-CoA reductase degradation protein 4) (P33755)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Substrate-recruiting cofactor of the CDC48-NPL4-UFD1 segregase. Assists CDC48 in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation. Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Regulates ubiquitin-mediated mitochondria protein degradation. Involved in spindle disassembly probably by promoting the degradation of spindle assemby factors ASE1 and CDC5 at the end of mitosis.
Subcellular location: Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Interaction partners:
- Protein DOA1
- UBX domain-containing protein 5
- Degradation in the endoplasmic reticulum protein 1
- DER1-like family member protein 1
- UBX domain-containing protein 2
- Cell division control protein 48
- Ubiquitin fusion degradation protein 1
- E4 ubiquitin-protein ligase UFD2
- Ubiquitin thioesterase OTU1
- ERAD-associated E3 ubiquitin-protein ligase HRD1
Sequence:
MLIRFRSKNGTHRVSCQENDLFGTVIEKLVGNLDPNADVDTFTVCEKPGQGIHAVSELADRTVMDLGLKHGDMLILNYSDKPANEKDGVNVEIGSVGIDSKGIRQHRYGPLRIKELAVDEELEKEDGLIPRQKSKLCKHGDRGMCEYCSPLPPWDKEYHEKNKIKHISFHSYLKKLNENANKKENGSSYISPLSEPDFRINKRCHNGHEPWPRGICSKCQPSAITLQQQEFRMVDHVEFQKSEIINEFIQAWRYTGMQRFGYMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMDVEQVKNEMLQIDRQAQEMGLSRIGLIFTDLSDAGAGDGSVFCKRHKDSFFLSSLEVIMAARHQTRHPNVSKYSEQGFFSSKFVTCVISGNLEGEIDISSYQVSTEAEALVTADMISGSTFPSMAYINDTTDERYVPEIFYMKSNEYGITVKENAKPAFPVDYLLVTLTHGFPNTDTETNSKFVSSTGFPWSNRQAMGQSQDYQELKKYLFNVASSGDFNLLHEKISNFHLLLYINSLQILSPDEWKLLIESAVKNEWEESLLKLVSSAGWQTLVMILQESG
Protein: Two-component sensor PprA (EC 2.7.13.3) (Q9HWA7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB.
Interaction partners:
- Two-component response regulator PprB
- TadE-like domain-containing protein
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MFEFSRSSSAEAERPEPFSQEGPALWSASLRSWDLCFEMDEQDRVIRVGGRQAYRLQCAHGLGEQPRPFAEYLERRAPGAPTLAGLRRGERLDLTLRSDAAAPLTCRFQPMQPLDGLGRSLLLGMDISDLNWQSDSQQHQLQSLSLGKLILSRLRHVSHGHLAEAVQEILESLSGAFQMQAIALLLGDGKGFCTVFASHVRPGSDSLLRPPLQLADDDLREGAGARLLRRGEGASTLLRQIGEDALYLVPATMRGGRLGALLVRPMSLEQLAQGPAPQDWQYLAELLANQVADRCELHEQHDSSRKLGLLQEMIGGGWWRYWAEQELFELAPALHDSLGLTGEYRRVPLEHLQGLLQPADADELGLRLRASLRSGQALAQDLCLRQPDSRGERRWLRIEGRPLGRGSALGLSGVLLDISEGRRQEERAQAAHARLRSLIDSAPVVIYVQRVEQGHLVPEFYSESASNLLGLDLQGQSWQALAERVHPDDLEAFFARGRELLREGRVKTRYRLADGQGNWHWLYDEAKLLRDAQGLPSEAVGLWLDVTEQHLAAQRIAESEERYRVLVEDSPALICRYTADLVLTYVNRTFADSLATSPERLVGRRLDEWLAAEDASALRARLLGSPREGASEVPELRFNLPGQRFLWLVWAERPLFDARGELCEVQAVGRDNTPVRRAQQQLAQGAKMASLGEMVSGLAHEVKQPLHVLRMTLFNMRQRMNSVGLDGDYLGEKLERMDAQVLRVDRLVSHLGVFSRKSALEALPFDPYAAFEGALGLLGEGLRQHAIEVECPAPTQRMVVRGQADQLEQVIINLLANARDALLGNPGLASRRVRLEQVACREPGWVELHVHDNGGGIEPLLLERIFEPFFTTKAEGKGTGLGLSVSHDLVRNMGGSLTAANQGEGALFVVRLPLAAPAEAGG
Protein: Trehalose transporter 1-like protein (Facilitated trehalose transporter Tret1-2 homolog) (DmTret1-2) (Q8MKK4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Fails to transport trehalose.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20035867}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:20035867}.
Interaction partners:
- Trehalose transporter 1
Sequence:
MKILMRADTHVSFSVPADGLKANFTFSQVLAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSFEVTKDAGSWVGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVCYVAGSFMNWSMLAFLGAALPVPFLILMIIIPETPRWFVNRGQEERARKALKWLRGKEADVEPELKELMQSQADADRQATQNTCLELFKRNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFFYCKAHGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIERKMMGRVPMSSVVNIKPFPFNM
Protein: Fluoride export protein 2 (Q08991)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26055717}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Histone H3-like centromeric protein CSE4
- Histone H3
- COMPASS component SWD1
Sequence:
MIFNPVISNHKLSHYIHVFCTFTTFCILGTETRQAITALSTYTPAFVTAPTVLWSNCSSCMLMGIMQSLNAYTWMKDHQVLFLGVTTGYCGALSSFSSMLLEMFEHSTNLTNGNIANHTKLPNRAYGIMEFLSVLLVHLMVSMGSLIFGRQLGKEVIVAYGSSSFSKPYTPPSDTVKENAGDVDTQEMEKNILEFKFKTPAPFFKKFFDVVDKLAYALAFPLIILFVVLCAYYENYSRGKWTLPCLFGIFAGFLRYWLAEMFNKTNKKFPLGTFLANVFATLLIGIFTMVQRGKKHFSTDIPIVNSLNSCHIVSALISGFCGTLSTISTFINEGYKLSFINMLIYYTVSIGISYCLLVITLGSYAWTRGLTNPIC
Protein: Putative E3 ubiquitin-protein ligase C36B7.05c (EC 2.3.2.27) (RING-type E3 ubiquitin transferase C36B7.05c) (Q9HGN5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- SPRY domain-containing protein C285.10c
- Myo-inositol transporter 1
- Inactive zinc metalloprotease C354.09c
Sequence:
MDEDETTYPEALRRLLIETPAAIWQLDDESAQCNNCGGPFTWFRRRHHCRWCGKLFCYNCCNSFAKLPVSSVSVDPTEDLIPQDMFIRDPDFLANDNDDDNDSQDSSWINVRVCVNCRQQLSELKELDLPYPITTCLNDDTTTRSNNQVIQSSCGNNLQRIEEPDDFVECPVCYAPLSSFKTLSERESHVANCLSNNSSSPRNMTEFLKHARRYISMQLSETSPCLGQECIICFEEFAAGDRVARIEYCLCIFHLKCYRDWLSTGAAGCPVHAATLHLS
Protein: IST1 homolog (Charged multivesicular body protein 8) (F5GXM3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKILCAKYSKEYGKLCRTNQIGTVN
Protein: Heat shock protein 105 kDa (42 degrees C-HSP) (Heat shock 110 kDa protein) (Heat shock-related 100 kDa protein E7I) (HSP-E7I) (Q61699)
Organism: Mus musculus (Mouse)
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10865058}. Nucleus {ECO:0000269|PubMed:10865058}. Note=Strictly cytoplasmic in neurons.
Interaction partners:
- BAG family molecular chaperone regulator 2
- DnaJ homolog subfamily B member 1
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 1B
- Hsp70-binding protein 1
- BAG family molecular chaperone regulator 1
- Stress-induced-phosphoprotein 1
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
Sequence:
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNIDKKEDLEGKNNLGAEAPHQNGECHPNEKGSVNMDLD
Protein: Akirin (Q966L3)
Organism: Caenorhabditis elegans
Function: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in antifungal innate immunity, development of the muscle and sister chromatid cohesion. Plays a role in antifungal innate immunity by acting as a bridge between components of the NuRD (Nucleosome Remodeling and Deacetylase) and MEC chromatin remodeling complexes. NuRD and MEC complexes bind to the promoters of antimicrobial peptide genes and may recruit other proteins such as ceh-18 to control gene expression in response to fungal infection. During meiotic prophase I, plays a role in the disassembly of synaptonemal complex proteins and in the regulation of chromosome condensation and segregation. Together with nuclear import receptor ima-2, required for the import and load of cohesin complex proteins in meiotic nuclei, possibly by acting as a bridge between ima-2 and cohesins. Required for embryonic development of muscle tissue.
Subcellular location: Nucleus {ECO:0000269|PubMed:30036395, ECO:0000269|PubMed:30563860, ECO:0000269|PubMed:31767636}.
Interaction partners:
- Importin subunit alpha-2
- Diphthine--ammonia ligase
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-4
- SWI/SNF chromatin-remodeling accessory subunit 2
Sequence:
MACGLALKRPLQHEYESFLTDETYNGEAKRARTQCPPFRAQMGTIAATLPSTSTFAQKFKEQEESVFQAATLMTRLSRNQLKTYLSSEVKNLRKRKAIPRSNDFDDDGDQRGDGCSSNYSKAYRAPSSPKSGSDSEGEAPSTSVTDRSSAKREFTMANVQMICERLLKQQEIRLRNEFEMVLTKKLDEQHQQYVQFAAEQLNSKCVSTGDDYSYSYLS
Protein: Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (mTaar5) (Trimethylamine receptor) (Q5QD14)
Organism: Mus musculus (Mouse)
Function: Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O14804}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14804}.
Interaction partners:
- Flavin-containing monooxygenase 3
Sequence:
MRAVLLPGSGEQPTAFCYQVNGSCPRTVHPLAIQVVIYLACAVGVLITVLGNLFVVFAVSYFKVLHTPTNFLLLSLALADMLLGLLVLPLSTVRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRTALRYIVAGWGIPAAYTAFFLYTDVVERALSQWLEEMPCVGSCQLLFNKFWGWLNFPAFFVPCLIMISLYLKIFVVATRQAQQIRTLSQSLAGAVKRERKAAKTLGIAVGIYLVCWLPFTVDTLVDSLLNFITPPLVFDIFIWFAYFNSACNPIIYVFSYRWFRKALKLLLSREIFSPRTPTVDLYHD
Protein: Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) (Q9JM52)
Organism: Mus musculus (Mouse)
Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Subcellular location: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Interaction partners:
- cAMP-regulated phosphoprotein 19
- Alpha-endosulfine
- Striatin
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Sequence:
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKAKPSSAGPEPPISQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEEEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEISGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSKGQSPPTKDGGSDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Protein: NADH-ubiquinone oxidoreductase 24 kDa subunit homolog C11E3.12, mitochondrial (EC 1.6.-.-) (O13691)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative acyl carrier protein, mitochondrial
- RNA polymerase I-specific transcription initiation factor rrn11
- NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Probable mitochondrial-processing peptidase subunit beta
- Cytochrome b-c1 complex subunit 9
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Cytochrome b-c1 complex subunit 8
Sequence:
MKPIRFFKPENLQLAKAILARYPLRFQSAALVPLLDLAQRQHGTWIPPTAMYEIASLAGVSIDYVHSLILAYPNDFFWRPKKPRVRICNSWMCQQAAEEQGNSNWDSQCRSVATKYGFDVENTGCLGNCFQGPAMWINDKIYGVNTKEKLVDIMEALTQKKN
Protein: UPF0426 protein At1g28150, chloroplastic (Q9FZ89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16461379}.
Interaction partners:
Sequence:
MGFVLICTCPPSSGVVVSQLHHHQFSAGVKSNELWFRPTRRTLISKSSCFNLPQEPILSEALKEPIAFLGGMFAGLLRLDLNEEPLKDWVTRTVEASGITEEEVDADGVVSNDEDSPQQIEIE
Protein: PR10-1 (E9M219)
Organism: Panax ginseng (Korean ginseng)
Interaction partners:
Sequence:
MGVQKTEVEATSTVPAQKLYAGLLLDIDDILPKAFPQAIKSSEIIEGDGGVGTVKLVTLGEASQFNTMKQRIDAIDKDALTYTYSIIGGDILLDIIESIVNHFTIVPTPDGGSIVKNTTIYNTIGDAVIPEENIKDATEKAGLIFKAVEAYLLAN