wanglab/gogpt-training-data huggingface dataset:
Protein: Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC 3.1.3.16) (P23636)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.
Interaction partners:
- Protein phosphatase PP2A regulatory subunit A
- Protein phosphatase PP2A regulatory subunit B
- Uncharacterized protein C63.05
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
- Serine/threonine-protein phosphatase 2A activator 2
- Serine/threonine-protein phosphatase 2A activator 1
- Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Leucine carboxyl methyltransferase 1
- Serine/threonine-protein kinase atg1
Sequence:
MSIDPANDSKLAPEANDATLGDVDRWIEQLKKCEPLSEADVEMLCDKAREVLCQENNVQPVRNPVTVCGDIHGQFHDLMELFKIGGDVPDMNYLFMGDYVDRGYHSVETVSLLVAMKLRYPNRITILRGNHESRQITQVYGFYDECLRKYGSANVWKHFTNLFDYFPLTALIEDRIFCLHGGLSPSIDSLDHVRTLDRVQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISETFNHANGLSLTARAHQLVMEGFNWAHDGDVVTIFSAPNYCYRCGNQAAILEVDDTMNQVFLQFDPAPREGEPVIARRTPDYFL
Protein: Calcium-binding protein NCS-1 (Q06389)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulator of phosphatidylinositol 4-kinase PIK1.
Subcellular location: Bud membrane {ECO:0000269|PubMed:11015193}; Peripheral membrane protein {ECO:0000269|PubMed:11015193}. Note=Buds and bud scars.
Interaction partners:
- Phosphatidylinositol 4-kinase PIK1
- FK506-binding protein 1
- ADP-ribosylation factor 1
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
- Serine/threonine-protein phosphatase 2B catalytic subunit A2
- Protein BMH1
- Translation factor GUF1, mitochondrial
- Protein BMH2
- Calmodulin
- Dynein heavy chain, cytoplasmic
Sequence:
MGAKTSKLSKDDLTCLKQSTYFDRREIQQWHKGFLRDCPSGQLAREDFVKIYKQFFPFGSPEDFANHLFTVFDKDNNGFIHFEEFITVLSTTSRGTLEEKLSWAFELYDLNHDGYITFDEMLTIVASVYKMMGSMVTLNEDEATPEMRVKKIFKLMDKNEDGYITLDEFREGSKVDPSIIGALNLYDGLI
Protein: Coiled-coil and C2 domain-containing protein 2A (A1ZAV1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27577095, ECO:0000269|PubMed:27646273}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27646273}. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme (PubMed:27577095, PubMed:27646273). Co-localizes with the tectonic-like complex (PubMed:27646273). {ECO:0000269|PubMed:27577095, ECO:0000269|PubMed:27646273}.
Interaction partners:
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- Tectonic-like complex member Mks1
- Centrosomal protein Cep290
- GEO07735p1
- Tectonic
- Uncharacterized protein, isoform C
- No mechanoreceptor potential B, isoform D
- Centriolar coiled coil protein 110kDa, isoform B
- Reduced mechanoreceptor potential A, isoform B
Sequence:
MEAALSRKTAKKKRKTHTTRGYRKREQEVQKLIRATEGRISGPEHDMEALSLQFFHGFEGEMQQENDFAVEDCQESDEDSGGELAEEPTDSPSQTFIHIDLHDPPLAWGQLFKQRHYYDESLLYRPSNTLHFQLHLSDLSELKDSQIRMLNRYQEQSKSKSGKLGSDLIGQLSGQKPASFLMGKHLYRSVCHRRFQSVFFPPMPPSELKGLPSRRCLKLCLKQLRFSLHPQLLEEHRLAQQLEDLFDVYSQQRKQRICRKLREELEIARQVALKLLASAGQDQTAEVKRQLKLTRQLRQRYYAESAAQRNLLQRLLKEWAKLKELRRQQRFQCTRFQLGLRVVHPPDLEASYCAWKESFETDLAEVYREHLELFYTRLRLWTDQKSHSRTATGHSKPPRKPQFDRIMASLRKEYDKTFKDPEEPYVEVFRLHADEATARLSIPGGDQLPKARNYFLKIFLDGQFVGQSRTYRLEPDLQISINECIGVLLERSLPENLNIWLYEKSTLTPKSRRLAQISTPLVLSSKDDAVQEKLSFQALSSTQLAGDVYLYYEYRSTEGWGSALHLDDVQRLPDALRQTLLPQSLPALPQASKELVTPRPPSGRIKKSQLPSLIFAEQQLQFCGLDVLLDNRRFQLLHSRHQQRNLHTKQLRFVPALEQEISEEEPLPDGRGTVQLLEPGTYWNPIDLHKHRGRKFLQLLYEVIASQSARRAKALQTPLPLLLLAEDSDRSSGTGWTALWRAFCSVFQGQRNSLPREPSGWSGHQSAPDLFKSFCVSLHVVRATGVPVRSRHILNLNERRSSAGGDMSTSLFVTQTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTWNEQLQLQIQSQFGDLRDDLKISLFDELIEQQYSDEASDVYQRVQCNWLGEFRVPINSLLASRTFEGCIELAMPKVLVGYKRPLIDSVTNMPTDQYPEFKEAVHLWFYLSIEPGGGDLAPLHSCALACAEKPELQQYLDERRLELQQLLPQPQRYVEPLVCTAQGKRVCLTRLMDPVPLPPAAVPSGENPLEICIRYVSLLSHLRSYDPCQGFRGVWLDNQSLLDSTWCSVKDLGVLLCNYMLSLGLECWLILGVSCPHGECSFVLFRQPETAELFLVSPATGKRYQLQDVHCPLRRIYCVVGKQNIYFNIQTETRVSMTHFNLQDGACWFPLFRRRVPAPQSGVQKLDYAYKRSYELSQLQKHIERKIMKKISAWRTTRKTIWNRAFQPRLHKILCDMEDLSTFSRGRYDEPIFSEQLEREFPNYRLYGFTLNFAYTNLAAISERIRTSCIHYNHDASVEFCVAVHLHAHANDVLSVWLFLLSMVPLVE
Protein: Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod) (Q9NZR1)
Organism: Homo sapiens (Human)
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Nebulin
- Alpha-adducin
- Beta-adducin
- Gamma-adducin
- Gelsolin
- Dematin
- Capping protein, Arp2/3 and myosin-I linker protein 2
- Protein 4.1
- Scinderin
- F-actin-capping protein subunit alpha-2
Sequence:
MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLTSLNIESNFITGTGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEADRR
Protein: Transcription factor HBI1 (Basic helix-loop-helix protein 64) (AtbHLH64) (bHLH 64) (Protein HOMOLOG OF BEE2 INTERACTING WITH IBH1) (Transcription factor EN 79) (bHLH transcription factor bHLH064) (Q9ZPW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical bHLH transcription factor that acts as positive regulator of cell elongation downstream of multiple external and endogenous signals by direct binding to the promoters and activation of the two expansin genes EXPA1 and EXPA8, encoding cell wall loosening enzymes. Transcriptional activity is inhibited when binding to the bHLH transcription factor IBH1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor IBH1
- Transcription factor PRE1
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC24 A
- Protein transport protein SEC23 D
- Transcription factor PRE6
- Transcription factor PAR1
- Protein BRASSINAZOLE-RESISTANT 1
- Transcription factor bHLH150
Sequence:
MLEGLVSQESLSLNSMDMSVLERLKWVQQQQQQLQQVVSHSSNNSPELLQILQFHGSNNDELLESSFSQFQMLGSGFGPNYNMGFGPPHESISRTSSCHMEPVDTMEVLLKTGEETRAVALKNKRKPEVKTREEQKTEKKIKVEAETESSMKGKSNMGNTEASSDTSKETSKGASENQKLDYIHVRARRGQATDRHSLAERARREKISKKMKYLQDIVPGCNKVTGKAGMLDEIINYVQCLQRQVEFLSMKLAVLNPELELAVEDVSVKQFQAYFTNVVASKQSIMVDVPLFPLDQQGSLDLSAINPNQTTSIEAPSGSWETQSQSLYNTSSLGFHY
Protein: PE-PGRS family protein PE_PGRS27 (Q79FP2)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- PPE family protein PPE64
Sequence:
MSLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTSVLAAGADEVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGAAGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLLGVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGGAGGAGFSRALIVAGDNGGDPGAGGAGGTGGAGSTIGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNGAPGAPPSGGDPNGGGGGAGGAGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATGATGLNGLGAGADGTDGGKGGNGGAGGGGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGANATVAGGAGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTGGAGGNGANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGNSQVVGGNGGDGGNGGNGGSAGTGGNGGRGGDGAFGGMSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGNGGAGGNGGLGGFGGNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGPGGHGGNGGNGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGGNGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTGGTGGQGANGGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV
Protein: Tyrosine-protein kinase etk (EC 2.7.10.-) (P38134)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein. Note=When the protein is overexpressed.
Interaction partners:
- Putative polysaccharide export protein GfcE
- Low molecular weight protein-tyrosine-phosphatase Etp
- Low molecular weight protein-tyrosine-phosphatase Wzb
- UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
- Tyrosine-protein kinase wzc
- Uncharacterized lipoprotein GfcD
- Uncharacterized protein GfcC
- Putative polysaccharide export protein Wza
- Uncharacterized lipoprotein GfcB
- Threonine-rich inner membrane protein GfcA
Sequence:
MTTKNMNTPPGSTQENEIDLLRLVGELWDHRKFIISVTALFTLIAVAYSLLSTPIYQADTLVQVEQKQGNAILSGLSDMIPNSSPESAPEIQLLQSRMILGKTIAELNLRDIVEQKYFPIVGRGWARLTKEKPGELAISWMHIPQLNGQDQQLTLTVGENGHYTLEGEEFTVNGMVGQRLEKDGVALTIADIKAKPGTQFVLSQRTELEAINALQETFTVSERSKESGMLELTMTGDDPQLITRILNSIANNYLQQNIARQAAQDSQSLEFLQRQLPEVRSELDQAEEKLNVYRQQRDSVDLNLEAKAVLEQIVNVDNQLNELTFREAEISQLYKKDHPTYRALLEKRQTLEQERKRLNKRVSAMPSTQQEVLRLSRDVEAGRAVYLQLLNRQQELSISKSSAIGNVRIIDPAVTQPQPVKPKKALNVVLGFILGLFISVGAVLARAMLRRGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEKE
Protein: Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (F1Q4N0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAPVYEGMASQVQVFSPHTLQSSAFFSVKKLKVEQSCNWDMTGYGTHSKVYSQNSKQSVSVAPVGINGASLQVSNSSLSYEQALLFPAGSGHIVVASASSTSGAAGQLLGSTGSSGSGSGGHNLTRRSTVSLLDTYQRCGLKRKSEELDNNNGSGSGSSVHVVEEQQPPAPMIQNNVQSGATVATATASTTATSKNSGANSEGDYQLLQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTYPLWRLKTPEDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLAEKADRREFIDLLTKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLNTVHSQATNLAPSSTSATLSLTNPDVSILNYQSALYQPSAAPMAAVAPRTMPLQPGAPQLCAARPDPFQQALIVCPPGFQGLQASPSKHTGYSVRMENAVPIVTQAPGAQPLQIQPGLLTQQAWPSGTQQILLPPAWQQLTHTSVQHATVIPDSMTSSQPLANWRNSHPHGSHYNPIMQQPALLAGHVTLPPQQPLNVGVAHVMRQPSNNQSNSKKNKQHQMNNRNVSGYDVSSTQPVTSPQRSKRVKENTPPRCAVVQNGPPSTCVPSQTCTGGGWGGEQACSTTRDHHGQHNPPRQTIIIPDTPSPAVSIITISSDTDEEDDLKQPTNTSTSSKQRKNVISCVTVHDSPDSDSSNTSPYAVDSRTNGPNANGYDSKGAVLDNYSNGNPRTIIIPPLKSQTSENLGECDRLLPADVMNHQNSTYKFKTSNGGFSGNNHTSGGVTGGGAYRQQRTGPHPFQQQPLNLSQAQQHMAVERNGGHRRQQAYITPTMATQAQYSFHNSPTHTANVHPHLAAPHLPGQPHLYTYTAPAALGSTGTVAHLVASQGSARHAVQHASYPPGIVHQVPVSMGHRVLPSPTLHHGQYQAQFAHQTYISASPVYTGYPLSPTKMNQYPYL
Protein: No mechanoreceptor potential C, isoform D (A8DYV6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSQPRGGRGGGRGGGVGRKTPSSLTGPPDESATPSERATPASKADSDPKDDSSSNGDKKDMDLFPAPKPPSAGASIRDTANKVLGLAMKSEWTPIEAELKKLEKYVANVGEDGNHIPLAGVHDMNTGMTPLMYATKDNKTAIMDRMIELGADVGARNNDNYNVLHIAAMYSREDVVKLLLTKRGVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGSDSAGKILQATDKRNVEFLDVLIENEQKEVIAHTVVQRYLQELWHGSLTWASWKILLLLVAFIVCPPVWIGFTFPMGHKFNKVPIIKFMSYLTSHIYLMIHLSIVGITPIYPVLRLSLVPYWYEVGLLIWLSGLLLFELTNPSDKSGLGSIKVLVLLLGMAGVGVHVSAFLFVSKEYWPTLVYCRNQCFALAFLLACVQILDFLSFHHLFGPWAIIIGDLLKDLARFLAVLAIFVFGFSMHIVALNQSFANFSPEDLRSFEKKNRNRGYFSDGPMTPFLAFERLFFAVFGQTTTLDINPMRHLRPEWTEVLFKFVFGIYLLVSVVVLINLLIAMMSDTYQRIQAQSDIEWKFGLSKLIRNMHRTTTAPSPLNLVTTWFMWIVEKVKARMKKKKRPSLVQMMGIRQASPRTKAGAKWLSKIKKDSVALSQVHLSPLGSQASFSQANQNRIENVADWEAIAKKYRALVGDEEGGSLKDSDAESGSQEGSGGQQPPAQVGRRAIKATLADTTK
Protein: Bidirectional sugar transporter SWEET1 (AtSWEET1) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 1) (Q8L9J7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane. Can transport glucose, and, to a lower extent, mannose, fructose and galactose.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21107422, ECO:0000269|PubMed:24027245}; Multi-pass membrane protein {ECO:0000269|PubMed:21107422}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24027245}.
Interaction partners:
- At2g39500/F12L6.16
- Sucrose transport protein SUC2
Sequence:
MNIAHTIFGVFGNATALFLFLAPSITFKRIIKNKSTEQFSGIPYPMTLLNCLLSAWYGLPFVSKDNTLVSTINGTGAVIETVYVLIFLFYAPKKEKIKIFGIFSCVLAVFATVALVSLFALQGNGRKLFCGLAATVFSIIMYASPLSIMRLVVKTKSVEFMPFFLSLFVFLCGTSWFVYGLIGRDPFVAIPNGFGCALGTLQLILYFIYCGNKGEKSADAQKDEKSVEMKDDEKKQNVVNGKQDLQV
Protein: Cypemycin N-terminal methyltransferase (EC 2.1.1.301) (E5KIC0)
Organism: Streptomyces sp
Function: Involved in the biosynthesis of the lanaridin cypemycin. The enzyme can methylate a variety of oligopeptides, cyclic peptides and the epsilon-amino group of lysine.
Interaction partners:
Sequence:
MSDPSVYDETAIEAYDLVSSMLSPGAGLVAWVSSHRPLDGRTVLDLGCGTGVSSFALAEAGARVVAVDASRPSLDMLEKKRLDRDVEAVEGDFRDLTFDSTFDVVTMSRNTFFLAQEQEEKIALLRGIARHLKPGGAAFLDCTDPAEFQRAGGDARSVTYPLGRDRMVTVTQTADRAGQQILSIFLVQGATTLTAFHEQATWATLAEIRLMARIAGLEVTGVDGSYAGEPYTARSREMLVVLERQ
Protein: BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) (M0R2A4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFTPPPDLEGLFSL
Protein: Zinc finger protein chinmo (Protein chronologically inappropriate morphogenesis) (Q9VQ30)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for morphological differentiation of postmitotic neurons during postembryonic brain development. Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage. Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye-antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis. In the adult testis, maintains the male identify of adult somatic cyst stem cells. Represses expression and alternative splicing of transformer pre-mRNA, resulting in the production of the male-specific isoform of transcription factor dsx which ensures male-specific transcription of target genes. Plays a role in actin nuclear localization through its involvement in repressing the expression of the kinase Cdi. This maintains the cofilin/actin-depolymerizing factor homolog tsr in its unphosphorylated state which is required for actin nuclear import.
Subcellular location: Nucleus {ECO:0000269|PubMed:17055440}.
Interaction partners:
- Zinc finger protein 1
- Signal transducer and transcription activator
Sequence:
MDPQQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMGDLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGGGMAAAANAAASSLSTLAASANIVDRCGSAGANIISGSAAGIGGSHSGGAGNGSGTVGIGGNGVGSGGGNNGPISLGSGAGAAHHLGGSTGILKQECDSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPRKRAIVRSPYSEQEQRGSVLRDGSKSSECPSPINKPPYHRPSSSASSTAPTEADTMHSERASPQSSRYENHSPSTTAGNGNATSSLERIVKSERNNGSANEANDDDRELMDESTDNGAEDLRVKLENLKYSPPPPPNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQEIGLAAGATIAPAHLAAAAAASAAATAAASNHSP
Protein: Salivary cystatin-L (Sialostatin L) (SialoL) (B7PKZ2)
Organism: Ixodes scapularis (Black-legged tick) (Deer tick)
Function: Inhibitor of cysteine proteinases. Inhibits host immune responses via its inhibition of host cathepsins. Contributes to the suppression of the host's immune response to tick salivary proteins and is important for successful feeding on hosts. Inhibits differentiation of host dendritic cells. Inhibits proliferation of host T-cells in response to antigen stimulus. Down-regulates TLR2-mediated host responses to infection by B.burgdorferi and the production of the chemokine CCL3 by host dendritic cells. Down-regulates host responses to infection by B.burgdorferi and the production of IFNB1 by host dendritic cells. Down-regulates IL1B production by host mast cells, and this then leads to impaired activation of IL1R1, resulting in decreased IL9 production. Inhibits host inflammatory reactions and recruitment of host neutrophils. Inhibits papain and cathepsin L (CTSL) (in vitro). Inhibits cathepsin S (CTSS) (in vitro). Inhibits CTSV and CTSC, but to a lesser degree (in vitro).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8MVB6}.
Interaction partners:
Sequence:
MTSSFALVLLLGGVAVCVATGVFGGYSERANHQANPEFLNLAHYATSTWSAQQPGKTHFDTVAEVLKVETQVVAGTNYRLTLKVAESTCELTSTYNKDTCLPKADAAHRTCTTVVFESLQGDKSVSSFECEAA
Protein: Protein shuttle craft (P40798)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo.
Subcellular location: Nucleus.
Interaction partners:
- AT28918p
- Peptidyl-prolyl cis-trans isomerase Fkbp12
- Small ribosomal subunit protein eS12
Sequence:
MAEYWQQLTNGAGEAGPGNESSAMADCNGGHESAAVGGSCNRHSNNNYVNFNQFIMQHNLGGGAPSNATSTMQHPVGSSYTNFSLGGGGGAFGLNPPVASASTSHFANVSHQSPNFYSQAMIPTYQNGDGIARVTVTSSYGSVNPSNSNFSSFYTPFGNNPFDFSASKLQASAPEFVPNFAKLSLEETPAAATTNGNSTASLETAINETRPRTLRAQEPAERGANNQCSNHNYERERERERDRDRDRERDRDRDRDRDRDRDRDRDRDSRPGNTRQQRRSDYRDDREDRYERSDRRRPQKQQRYDNHRSNKRRDDWNRNRDRINGFPRAVDDLDTSNESAHPSPEKQSQLQQISPRRGPPLPPADNEKLSQREKLVRDIEQRRLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSSKSEVGWRCPACQNVLQDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCRIEGCSHACTLLCHPGPCPPCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLLNCGEHRCQAECHSGKCAACSEQVVQQCHCGKQERKVPCTRESQDKRTYSCKDSCGQPLPCGHHKCKDSCHAGSCRPCKLSPEQITSCPCGKMPVPAGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHLGQCPPCPKQTGVKCRCGHMDQMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECCIDIDHDCPLPCNRTLSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGAEVIYPPVPCGTKKPICKLPCSRIHPCDHPPQHNCHSGPTCPPCMIFTTKLCHGNHELRKTIPCSQPNFSCGMACGKPLPCGGHKCIKPCHEGPCQSAGEICRQSCTKPRPTCGHKCAAACHEGACPETPCKELVEVQCECGNRKQNRSCQELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAKKSNKTLDCNDECRLLERNRRLAAALSSGNSDTKQKCLTKYSEFVRGFAKKNPALTKSVYETLTDLVKLAKESKQRSRSHSFPTMNREKRQLVHELCEVFGIESVSYDKEPNRNVVATAHKDRCWFPATSIMEVLARESGQRRVPVPSNNAWGLKK
Protein: Adapter molecule crk (Proto-oncogene c-Crk) (p38) (Q63768)
Organism: Rattus norvegicus (Rat)
Function: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Subcellular location: Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Breast cancer anti-estrogen resistance protein 1
- CRK SH3-binding GNRP
- Paxillin
- Focal adhesion kinase 1
- Dedicator of cyto-kinesis 1
- Proto-oncogene tyrosine-protein kinase Src
- Fibroblast growth factor receptor substrate 2.
- Tyrosine-protein kinase
- Receptor protein-tyrosine kinase
Sequence:
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPEEDFS
Protein: Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) (Q54KR1)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Leucine--tRNA ligase, cytoplasmic
- Probable cysteine--tRNA ligase, mitochondrial
- Tryptophan--tRNA ligase, cytoplasmic
- Probable valine--tRNA ligase, cytoplasmic
- Probable valine--tRNA ligase, mitochondrial
- Cysteine synthase
- Cystathionine beta-synthase
- Tryptophan--tRNA ligase, mitochondrial
- Probable asparagine--tRNA ligase, mitochondrial
- Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Sequence:
MSENSSPKLESTSAAAASTKKPFPEWIKPKGKETELLINNSLTGGKVPFVFNESGKGRSLTWYACGPTVYDASHMGHARTYISFDIIRRIMKNYLGFNIQYVMNITDIDDKIIIRANENGISHSDLSKKWETAFFEDMKLLNVLPPDALTRVTEYVPQIVEYVEKIISNGFAYESNGSVYFDTVAFSKAHDYGKLEPNSVGNEKLAAEGEGSLTATSAVSEKRSGFDFALWKKSKPGEPVWNSPWGEGRPGWHIECSAMASDLLGGNIDIHSGGSDLKFPHHDNELAQSEAFYGNRQWINYFVHSGHLLIDGLKMSKSLKNFITIKQALEKYTSRQMRMFFILHKYDKAMNYSPESMGYAIEMEKTFVEFFHTAKQILRDSPLSLPQFWTQAEKDLNKHLQNANDQVHQFILDNFNTSDALKTLSDLVNKTNVYIRSCAEQKTNPRLNLISAIAEYITYIFSVFGLTESSTASSMIGFGSAGKGNIEEEMTPILNALTQFRSEVRASAIAKDTTSILKTCDNLRDEVLPLLGVKIDDKSATTAMWKFEDKETLKKEIEQKKEIEKKKQADKEEKEKKLKEKFEKSKIPPQQLFINETDKYSKFNELGMPTHDKEGVEITKSQLKKLQKEYDNQTKEHNNYLKSLSTSTSSPTLTSTQSPQ
Protein: Protocadherin 9 isoform 2 (Q2TJI1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
RCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQGIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQSQRRVTFHLPDGSQESYSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWIKKDKLVNGHTLTRAWKEDTNRNQFNDRKQYGSNEGHFNNGGHMADIPLANLKSYKQAGGTIESPKEHQL