wanglab/gogpt-training-data huggingface dataset:
Protein: Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) (Q7Z794)
Organism: Homo sapiens (Human)
Interaction partners:
- Keratin, type II cytoskeletal 1
- Keratin, type II cytoskeletal 2 epidermal
- Keratin, type I cytoskeletal 10
Sequence:
MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRCGGGGYGIHGRGFGSRSLYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQTSTNTSHRRILE
Protein: Uncharacterized methyltransferase C70.08c (EC 2.1.1.-) (O74529)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable methyltransferase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- UPF0654 protein C869.09
- Probable secreted beta-glucosidase C2G2.17c
- Uncharacterized amino-acid permease C74.04
- UPF0654 protein C11D3.01c
- Antisense-enhancing sequence 1
- Zinc finger protein klf1
Sequence:
MPEDYWSAKDYQRNASFVPKLTKDIVKRINLSSSDELLDLGCGDGVLTNELVSQCRRVVGIDASPDMIKAARELGLNAYVIPGEKLLDASEIPSESFDVVFSNAALHWIMRQPKNRPIVMKGVSRVLRTKGRFVAECGAFGNVSEVVGSIYSILLALGATKEQIDQANPWFFGSEDDYTRMLEEAGFHVEYVENISRPTLLNKDVREWLDTFAQHFYHAFPQWKDIIRETVYNALLVTDCRSDGKWFLQYRRLRFVAHKE
Protein: Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) (Q01118)
Organism: Homo sapiens (Human)
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular location: Cell membrane {ECO:0000305|PubMed:35301303}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium channel regulatory subunit beta-1
- Sodium channel regulatory subunit beta-3
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 5 subunit alpha
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Sodium channel regulatory subunit beta-2
Sequence:
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI
Protein: Jacalin-related lectin 34 (O04310)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g20370/MQC12_13
- Beta-glucosidase 23
- TSA1-like protein
- Tryptophan RNA-binding attenuator protein-like protein
- Transcription factor NAI1
- Tryptophan RNA-binding attenuator protein-like protein
- Calcium-dependent lipid-binding
- GDSL esterase/lipase 22
- Protein SPIRAL1-like 3
- Altered inheritance of mitochondria protein
Sequence:
MSWDDGSHAKVKKVQLTFDEIIYSIQVTYDGATALQSQLRGSVGPKSAEFTLAPDEYITALSAYGKSLSTQEVITALTFTTNKTSYGPYGTKSGFQISAPEATGKQISGFLGTSGNVLNTIDVHYSPIPTGGTGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTGTGTGTGTGGTGTGTGTGGTGTGTGTGTGTGTGTGTGTGTGTGGTGTGTGTGGTGTGTGTGTGTGTGTGGTGTGTGTGTGSGAQKLEAQGNSTGGTSWDDGSDYDGVTKIYASYGGEGIQYVKFDYVKGGVTKQGVLHGKQQSRQNPREFVINHPDEYLVSVEGWYETVMLGIQFKTNLNTYEVSIYPFEPSTDTKFTLQVQDKKIIGFHGFAGNHVNSIGAYFVPKSSTTPVPSTPLKLTAEGGETGAVWDDGSHDDVKKVYVGQGQDGVAAVKFEYKNGSQVVFGDERGTRTLLGFEEFELESDEYITSVEGYYEKNFGVDTVVTTLIFKTSKNKTAGPFGIVSGTKFEFKKEGYKITGFHGRAGEYVNAIGAYLAPSGTTPLTPATQSQKLEGAGSEAGTLWDDGAFDGVRKVSVGQAQDGIGAVSFVYDKAGQVVEGKEHGKPTLLGFEEFELDYPSEYITAVDGTYDAIFGNEPIVNMLRFTTNKRVSIPFGIGAGTAFEFKKDGQKIVGFHGRAGDLLHKFGVHVAPITK
Protein: Type 1 protein phosphatase-activating protein (Q5AHH6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Serine/threonine-protein phosphatase
- Type 1 phosphatases regulator YPI1
- Serine/threonine-protein phosphatase
- Type 1 phosphatases regulator YPI2
- Protein phosphatase regulator
- Protein phosphatase regulator
Sequence:
MPIQETNKELVEKPVGILQEEEKEEPILSHTEDEDDDDDDDEDEDDKNQQGNSAVQYPGTVLPDNHPQEIEADQDLTTGYDLDTDYIDLVHLKISSLEDLHLERFKKLESLCLRQNLITSMVGVKDLPDTLEELDLYDNRINHISSSIKHLVHLTNLDLSFNRIKNIKNIETLVELENLYFVQNKIREIKNLDTLTKVTNLELGGNKIEVIENLDKLVNIKQLWLGKNRIYKLQNMDNLVNLRVLSIQSNRITKIEGLENLKNLEELYLSHNGISEIENLENNINLQVLDVTANKISNLKGLSHLVKLTDFWCSYNQVSSFEEIGKELGKLPDLECVYFEGNPVQLQNPSAYRRKMKLYLGPSLNKIDATYVHS
Protein: Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) (P18265)
Organism: Rattus norvegicus (Rat)
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (By similarity). May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (By similarity). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- Glycogen synthase kinase-3 beta
- Catenin beta-1
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
- Axin-2
- Beta-transducin repeat containing E3 ubiquitin protein ligase
- Microtubule-associated protein tau
- TNF receptor-associated factor 6
- Transcription factor A, mitochondrial
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRSLGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPSGPATLTSSSQALTETQTGQDWQAPDATPTLTNSS
Protein: Serine rich endogenous peptide 6 (AtSCOOP6) (Phytocytokine SCOOP6) (Precursor of serine rich endogenous peptide phytocytokine 6) (Q0WML3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation. Inhibits root growth.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:B3H7I1}. Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:B3H7I1}. Note=The precursor of SCOOP6, PROSCOOP6, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP6 in the apoplasm. {ECO:0000250|UniProtKB:B3H7I1}.
Interaction partners:
Sequence:
MGTKCYSKLRYVVVLVLLLFVFPCSLSQSAPSSVTGRRLMGIYMPNGGIIAGSSPSGQAPNINNNYHGRRLMISEARPSKSKKGGGREPESPG
Protein: At5g57040 (Gb|AAD55473.1) (Lactoylglutathione lyase / glyoxalase I family protein) (Q9LTR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Gb|AAF24581.1
- At2g32090/F22D22.16
- 4-hydroxyphenylpyruvate dioxygenase
- Probable lactoylglutathione lyase, chloroplastic
- Lactoylglutathione lyase
Sequence:
MASIFRPSSASLDLRPKVICTNLSTKERFEFQKKSVRKERINVRFYSLKAKAQGSSIEGISVVQEKELNNKTDYGVVGVHHVGLLCENLERSLEFYQNILGLEINEARPHDKLPYRGAWLWVGSEMIHLMELPNPDPLTGRPEHGGRDRHACIAIRDVSNLKEILDKAGIAYTMSKSGRPAIFTRDPDANALEFTQV
Protein: Uncharacterized protein YJL132W (P47014)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- GPI-anchored wall transfer protein 1
- Putative Xaa-Pro aminopeptidase FRA1
- Protein BMH2
- Protein BMH1
Sequence:
MSIISSWLLVSIICLTTSIVTKLQAAGVTTHLFYLTRGAPLSLKENYYPWLKAGSFFPDALYSCAPSNKDWSDFAEFTHWPNFLMIAVSYWQQKYGQNDRLRGTHGSLALKSFLIGVFTHQIVDVSWHSLVTDYRMHGLLRVLSETEFDGDIETAHTFLDVMGEFLTLNNVIRDSNNNENWDFLTRSDWKLPREEDLMEIIRNAGLSKEKLSYAELEFCVKRGMAAAISEGYLFRSQRNQLLTNIYSTSPRANDLILNHWLGGQSNLVAMLQRCVPFFETLFHDENTNEAQAEELRLCANLPPVSQKRINARPLVSSLKARKGNSHIVVSPMKSFSDFGTSLTMGKFREDNKDYLAVSAPLEDTVGAIYIVPWDILTVARKEDFSILQPITAMYGSKVGTYKASDVDYLLVSQPGTCTIDFYFKGVKILTIKDETTEEAHQLQFAVTGNFYDDKIPDLVVSSPSYGANETGIATFIPGSSIISYLTNSDKYQVVDISTFKGVINLDGYPMKIPFQHFGATIQISDTTDKQKLIYITCQSLGTVFVYSSNDLHDLSIPIYYITKNGVIPAKDSDHVEWHIIPSKEHGMFGAAIYSWNFEGMSFVAVSQPMFDTVFIYIEKSGQIEFFLKLVLKIKTKSDSIPDEFGSSLLFNDEEKKLYVSSPGSFDARGSIWKISMDELLKAGNDPKRKTLLINNLRHLMLINPDKSSKGVSNFGNSMILGPQNHLIVGIPQYGYGNFDHMQLTGRILVL
Protein: N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-) (Q8N3J2)
Organism: Homo sapiens (Human)
Function: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation. Internal m6A(m) methylation of snRNAs regulates RNA splicing. Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo. Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending. N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942}. Cytoplasm, cytosol {ECO:0000269|PubMed:32183942}. Mitochondrion matrix {ECO:0000269|PubMed:32183942}.
Interaction partners:
- N
- Pre-mRNA-splicing regulator WTAP
- N
- Protein virilizer homolog
- RNA-binding protein 15
- Nucleic acid dioxygenase ALKBH1
- Methyltransferase HEMK2
- RNA N
- RNA demethylase ALKBH5
Sequence:
MSVVHQLSAGWLLDHLSFINKINYQLHQHHEPCCRKKEFTTSVHFESLQMDSVSSSGVCAAFIASDSSTKPENDDGGNYEMFTRKFVFRPELFDVTKPYITPAVHKECQQSNEKEDLMNGVKKEISISIIGKKRKRCVVFNQGELDAMEYHTKIRELILDGSLQLIQEGLKSGFLYPLFEKQDKGSKPITLPLDACSLSELCEMAKHLPSLNEMEHQTLQLVEEDTSVTEQDLFLRVVENNSSFTKVITLMGQKYLLPPKSSFLLSDISCMQPLLNYRKTFDVIVIDPPWQNKSVKRSNRYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRFIKEELYPSWSVEVVAEWHWVKITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEVLKFQHVDYFIAVESGS
Protein: DNA protection during starvation protein (EC 1.16.-.-) (Q0P891)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (Probable). Does not bind DNA.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- ATP-dependent Clp protease adapter protein ClpS
- 26 kDa antigen
- Flagellar motor switch protein FliN
Sequence:
MSVTKQLLQMQADAHHLWVKFHNYHWNVKGLQFFSIHEYTEKAYEEMAELFDSCAERVLQLGEKAITCQKVLMENAKSPKVAKDCFTPLEVIELIKQDYEYLLAEFKKLNEAAEKESDTTTAAFAQENIAKYEKSLWMIGATLQGACKM
Protein: Always early (Q2PNN6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRVKPGVASKRTENFTKKPSNISVDVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGNSFEGIVNGTVMGYDPQDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLRILHDYLVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNGKLGRENSSNLETIIADLVTHMVDNIQPSLGRKLKDGVDSLEPLRQQVVQIFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS
Protein: UPF0688 protein C1orf174 (Q8IYL3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:22361696}.
Interaction partners:
- Serine/threonine-protein kinase PDIK1L
Sequence:
MRSRKLTGAVRSSARLKARSCSAARLASAQEVAGSTSAKTACLTSSSHKATDTRTSKKFKCDKGHLVKSELQKLVPKNDSASLPKVTPETPCENEFAEGSALLPGSEAGVSVQQGAASLPLGGCRVVSDSRLAKTRDGLSVPKHSAGSGAEESNSSSTVQKQNEPGLQTEDVQKPPLQMDNSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDDDDDDDAEM
Protein: Toll-like receptor 9 (Q6Y1S0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle, phagosome {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MVLCSRTLHPLSLLVQAAVLAEALALGTLPAFLPCELKPHGLVDCNWLFLKSVPHFSAAEPRSNITSLSLIANRIHHLHNLDFVHLPNVRQLNLKWNCPPPGLSPLHFSCRMTIEPKTFLAMRMLEELNLSYNGITTVPRLPSSLTNLSLSHTNILVLDASSLAGLHSLRVLFMDGNCYYKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNLTEVPRQLPPSLEYLLLSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPDLCTECRQKSLDLHPQTFHHLSHLEGLVLKDSSLHSLNSKWFQGLVNLSVLDLSENFLYESINKTSAFQNLTRLRKLDLSFNYCKKVSFARLHLASSFKSLVSLQELNMNGIFFRLLNKNTLRWLAGLPKLHTLHLQMNFINQAQLSVFSTFRALRFVDLSNNRISGPPTLSRVAPEKADEAEKGVPWPASLTPALPSTPVSKNFMVRCKNLRFTMDLSRNNLVTIKPEMFVNLSHLQCLSLSHNCIAQAVNGSQFLPLTNLKVLDLSYNKLDLYHSKSFSELPQLQALDLSYNSQPFSMQGIGHNFSFLANLSRLQNLSLAHNDIHSRVSSRLYSTSVEYLDFSGNGVGRMWDEEDLYLYFFQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFLPNLRDLDLAGNLLKALTNGTLPNGTLLQKLDVSSNSIVFVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVSSNPLHCACGAPFVDLLLEVQTKVPGLANGVKCGSPRQLQGRSIFAQDLRLCLDDVLSRDCFGLSLLAVAVGTVLPLLQHLCGWDVWYCFHLCLAWLPLLTRGRRSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDKVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPHQPNGQGSFWAQLSTALTRDNHHFYNRNFCRGPTAE
Protein: Ferrochelatase (M1VBI3)
Organism: Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga)
Interaction partners:
- Protoporphyrinogen oxidase
- Similar to frataxin
- Heme oxygenase
- Protoheme IX farnesyltransferase, mitochondrial
- magnesium chelatase
- Mg-protoporphyrin IX chelatase
- magnesium chelatase
- Uroporphyrinogen decarboxylase
- Uroporphyrinogen decarboxylase
Sequence:
MFVVVPGNAWRLPRPRGGLHRRPTWRLSLIHGSEDGQHALTSSGTARNAASPATSTTATATTARVANRGTAGSASFLEPRFQGRTGLILVNIGTPASLNVADVRRYLREFLGDDRVVDIRPKWLKTILLQVLLLTRPAKSAEAYANIWDKETGSPLLHYSQELATKIQKRVGNGYAVAVGMQFGEPNLVSVMHDFRRRGIDRMIIVPMFPQYASSTTGSASEMAYHTASKLYSTPYLHIVPAFYDHPAYIQAYANVIERVIGPRGSRRVDHLLLSFHGVPEKHCQQTDDTGLVCMQQEHCCSALVQANRNCYRAQCFATARALAQTLGLAPHEYSVSFQSRLTAAGPEWIKPYTDEVLTILPKQGVRRLAVAIPSFVTDCLETLEEIGMQGREEFLNAGGEEFYLVPCLNDSQEWADALLRIIEDSC
Protein: Unconventional myosin 29D (Q8T6L9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVAKNAEVHRRGILGFAPRIGLVNVDYDDLDRIDNFYLETQRYRDYYRDPHNILHKPERFRQHQGKCSIKLDTSVQNLTRPIHASSSNEAVHLQQRLKSLSTELVTLRNRLHVGHGPGQGQSQGNGAQPVAPAPNAGPKANNFDLNASSPNLNLSSSGAGLSASAVQQHTNGHHTTSKNHSFSHTLPANSGSGGGGGAGGGAVVSARNTSIPHPLPHQLAEKPGLSHQQSGSGHGQSTGTLPHMSGMGSILGQNSHSHAPVNNNSNNSNTLPMRTSNSGHLGINGGGVGHHLSHAHSQQLPFIPQSKHTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTDGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFIDGGGLEVDVKGETELNSVASLLGVPPAALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSVRGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKKMGNGGAKRSKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISGEIPPRVYPFSAHLIPKLYDAVPRLSAKTTSLGIGGTVARPRPQPIAGTPPPDPQEKCDQKIIQQTCNLFGGTSAASSAVSFLHDHREFENKLSPKPGHEDELSRGGTVGGAAAEEGRSGDRSGGLHRSGSPDGGAQGAELPRSLPVHDAQ
Protein: Ral GTPase-activating protein subunit beta (p170) (P86410)
Organism: Rattus norvegicus (Rat)
Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
Interaction partners:
Sequence:
MYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQALGHSPVSASQSLLYTDKDVKWTMEVICYGLTLPLDGETVKYCVDVYTDWIMALVLPKDSIPLPVIKEPNLYIQSILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSIMARETWEVLLLFLLQINDILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPPFKVPDEDANLIPPEMDNECIAQTWFRFLHMLSNPVDLSNPAVISSTPKFQEQFLNVSGMPQELSQYPCLKHLPQIFFRAMRGISCLVDAFLGISRPRSDSAPPTPVNRLSMPQSAAVNTTPPHNRRHRAVTVNKATMKTSTVTTAHTSKVQHQASSTSPLSSPNQTSSEPRPLPAPRRPKVNSILNLFGSWLFDAAFVHCKLHNGINRDSSMTASFIQILLSYKSSIATQASMEFRRKGSQMSTDTMVSNPVFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEILPAYLSSVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPLPHHFGTVRSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEALGCQMEMGGGENNLKSHSRTNSGISSASGGSTEPTTPDSERPAQALLRDYGSTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDLGDRKRAISSVCSYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNSEQEVKYKGDKEPNPASMRVKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGRLAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEMHLEQQSEGELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYMKPGQKTNQEILKNVESSRNVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINSCDDGEGSEQDEVTSSEDVGASIFNGQKKVLYYADALTEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPPLTLELVPNHTDSLNSSQRLSPSSRMKKLPQGRPVPPLGPETRVSVVWVERYDDIENFPLSDLMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQTVINICRRKRLESDSYSPPHVRRKQKITDIVNKYRNKQLEPEFYTALFQEVGLKNCSS
Protein: Probable transport protein MmpL2 (P9WJV7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable transport accessory protein MmpS2
- Uncharacterized protein Rv0508
- Hydrolase
- Conserved protein
Sequence:
MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDFWGDPLTAAGSQSADDRAAYVVVYLVGNNETEAYDSVHAVRHMVDTTPPPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYHESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTVGSFFKLFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGDAAAGRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQMRAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGISRVEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAISLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQHPSATGAHE
Protein: Lipopolysaccharide induced TNF factor (I3L1I9)
Organism: Homo sapiens (Human)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004125}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004414}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004630}.
Interaction partners:
Sequence:
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFC