wanglab/gogpt-training-data huggingface dataset:
Protein: Disheveled-associated activator of morphogenesis 2 (A0A1D5P556)
Organism: Gallus gallus (Chicken)
Function: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly (By similarity).
Interaction partners:
- Dishevelled segment polarity protein 3.
- GTP-binding protein
- Segment polarity protein dishevelled homolog DVL-1
- Uncharacterized protein.
- Profilin
Sequence:
MAPRKRNRHALGFLCCFGGSDLPEINLKDNNPLQFLDFTVPIPPTEELNARFSELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQTLYAFDEEETEMKNKIVEDLKTALRTQPMRFVMRFIELDGLSCLLNFLKSMDYETSESRIHTSVIGCIKALMNNSQGRAHVLAHPESINIISQSLRTENIKTKIAVLEILGAVCLVPDGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSMGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLREHENATLDRHLDFFEMVRNEDDLELAKRFDLIHIDTKSASQMFELIKKRLKHTDAYPYLLSILQHCLQMPYKRNGGNFQQWQLLDRILQQIVLQDERGDDPDIAPLENFNVKNIIKMLVNENEVKQWRDQAEKFRKDHAELMSKLEKKERECETKTQEKDEMMKTLNKMKDKLQKESLELRQARDQMNDLVAQLNEYSQGGSISFPAPPPPPPGGPLALSSALSSALTSENLPPLPPPLPFSSCPPPPAPPPPPGGPPPPPGAPPFFSLGVPPPSTTTFSSAGTSLKKKSIPQPSHPLKSFNWAKLSEERIHGTIWNEIDDLKAFKVLDLEDFEKMFSAYQRHQKEMGSTEDLYLSTRKVKELSVIDGRRAQNCVILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFVPEKSDTDLLEEHKHEIERMARADRFLFEMSRIDHYQQRLQALFFKKKFPERLAEAKPKVEAILLASKELIRSKRLRQLLEVVLAFGNYMNKGQRGSAYGFKVSSLNKIADTKSSIDRNITLLHYLIMIFEKNYPDILDIQTELQHLPEAAKVNLVELEKEVNNIKTGLKAVEAELDYQKRRIRESGDRFVPVMSDFITVASFSFSELEDLLNDARDKYAKALKHFGENEGKMQPDEFFGIFDTFLQSFAEAKQDLENMRKKKEEEERRARMEAMLKEQREKERRQKKAKAGSISEETGEFDDLVSALRSGEVFDKDLSKLKRNRKRSGNQGLETSRERVVTKLNY
Protein: Heat shock transcription factor 1 (Q63717)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
FRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSSSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKEEPPSPPHSPRVLEASPGRPASMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAHPAPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNADSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
Protein: Carboxylesterase notum2 (EC 3.1.1.-) (E7F0Z8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
Interaction partners:
- Palmitoleoyl-protein carboxylesterase notum1a
- Protein Wnt-1
- Protein Wnt
- Protein Wnt-5b
- Semaphorin-4E
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
Sequence:
MNIFCHALFLLLLGVVSCQNNNRNVKPGGKPAKKPNNPAIEATQHGPEADPNSGLAGAGDSSKETNPGGRGSSQQSASVNKPADDMKLHFLKNTAVTCNDGTAAGFYLKEFKGSKRWLIFLEGGWCCYSKETCDSRYKTIPRLMGSTDWPQTRRGSGLLSAQVDENPHWYNANIVFVPYCSSDVWSGNKAASKPKQGKETEYAFMGSQIIREVIKDLVPKGLKQAKVVMLAGTSAGGTGVLLNIDKVSSLLEQQGAEAQVRGLVDSGWFLESKQQKVPDCPDSASCTPADAIKKGLRLWNGVVPEKCKQQYKRGEDWHCFFGHKLYSYISAPLFVVQWLFDEEQLRVENIYMGSQSLSEQQWTYMQNLGKELKNSLKDVTAVFAPSCLSHTLITKSNWTDFQIKGTSLSRALQCWDRSFQEANKNSKTALKGCPFHLIDNCQWPQCNPTCPALIDQATQQEMTLLQVLASMGLDLQKLGLDVRGDISAGMVSNGG
Protein: Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (P59708)
Organism: Mus musculus (Mouse)
Function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y3B4}.
Interaction partners:
- Splicing factor 3B subunit 1
- Splicing factor 3B subunit 4
- Splicing factor 3B subunit 5
- Splicing factor 3B subunit 2
- Splicing factor 3B subunit 3
- PHD finger-like domain-containing protein 5A
- Splicing factor 3A subunit 2
- Small nuclear ribonucleoprotein E
- Splicing factor U2AF 65 kDa subunit
- Pre-mRNA-processing factor 6
Sequence:
MAMQAAKRANIRLPPEVNRILYIRNLPYKITAEEMYDIFGKYGPIRQIRVGNTPETRGTAYVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYNANRAFQKMDTKKKEEQLKLLKEKYGINTDPPK
Protein: Hepatocyte growth factor receptor (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (Tyrosine-protein kinase Met) (Q64GK4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTIHYSEAASILIILQSLWWGLNCQCEEPIESSKLDLSVTYDLPYFVSDTPIQKLLEINGTVYVGAVNRLYALSKDLKKKHEYKTGPVHEGPDCKTPTDQCSGCENKPRNINNTNMALLMETFYDLELFSCGSVGNGVCSRHVLEDGPLGAEVTCMYTKKNEGSSHGCPDCLAGPAGTQILNIMSGRVVRFFVANSEPLESNGPRLHHTISIRKMRETQDGFEFFSEQSYMDLAPSLRGNYPLHYVYSFQSGPYVYFLTVQREGGNSKAFHTRIVRMCSSDSEILRYVEMPFECIYSERRRKKRSAQVVFNVLQAAHVAKVGYDFQQEMGLKEGEDVLFAAFARSKPDSPEPTASSAVCLISITDINEFFKVFIQKGYTRKLHHFPGSEEKTFNQTFVGDSFSCGKHERGYRLEVTSTNPRRDYFHGRFRNVLLTSIAVVPIQNHTVVSLGTAEGRVIQVVVSRFGKTEPHVDFRLDMLPVSSEMALLSPQHHNGSLLLITGDKVSKLPVIGPGCEQLWTCSSCLLAPGFMGCGWCRTSNRCTRAPRCPQSQWIQDSCPLLITSISPSSAPLRGQTNITICGKNFGFNKKDRFDTKLVDVVVAGTKCKLERKDSNNNRLVCGLDYVNWSSLDSVITVRSGKEQAQKDGFSFVNPVIIEIFPEFGPQSGGTMLTISGSFLDSGNVQTVTVGNATCVLQSVSATMLTCRTPPQPSPSQHKVQLHIDGVIFEAPVSYTYNKNPHISSVQPKHSFISGGSTVTVNGFYLHSALQPQMVLTAATEGKLFQVTCSHDEDKRNILCITPSLKGLSVQPPVATKMTFVLDGFSTDQYDLLYVEDPKFEEFQKPTVTPRGKKNILEIKVPPVNQEAVKNGEVLRVSNRTCESVTLVGNTLECTVPMELQTAAKELEVEWKQATSSVILGRVILAQDQDYRILITGGVCVSILLLLLIAVFVWIKRKKHIDDLAKTMVWYDGRAHIPHLDMLANARSVSPTDEMVSHESVDYRTTLLEDQNLPLSQTESCRPHLYAHSHVDLSPMLGPMEGDLASPLLPSTAPIDLGSLHPELLKXVQHVVIAREDLLLHVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIVKDFSHPNVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRDESHNPTVKDLMGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADVGLARDVYDKEYYSVHNKHGVKLPVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVMIECWHPKPERRPTFLELVSRISAIFSSFSGEHYILLNTTYVNIDKMTPYPSLISSQSNLDRDCCT
Protein: Chorion-specific transcription factor GCMb (hGCMb) (GCM motif protein 2) (Glial cells missing homolog 2) (O75603)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.
Subcellular location: Nucleus {ECO:0000269|PubMed:20190276}.
Interaction partners:
- Extracellular calcium-sensing receptor
- Chorion-specific transcription factor GCMa
- Parathyroid hormone
- Heat shock transcription factor, Y-linked
- Forkhead box protein N1
Sequence:
MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF
Protein: Interleukin 34 (R4GIU3)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein.
- Syndecan
- Protein-tyrosine-phosphatase.
- C-X3-C motif chemokine receptor 1
- Mast/stem cell growth factor receptor Kit
- Triggering receptor expressed on myeloid cells 2
Sequence:
MHQGCAAVLCVLAVLGLEVAALGECELARLLQDKLRYEMRLQYMKHNFPIDYTLRVQHEEVLRTANVTRLRDGKVSEASLRYLWFHACSQAVLHILEVLPEKHPSRGYTQELSQLLDALGVEYSGYRQSDVDAVVADLVKQLHSGDSRQKAVRPKALLDNCLKVLRMLFGAHCRWDSA
Protein: ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (ASPPase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Q93K97)
Organism: Escherichia coli (strain K12)
Function: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
Interaction partners:
- Uncharacterized protein YqiB
- 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
- ADP compounds hydrolase NudE
- Ribose-phosphate pyrophosphokinase
- Phosphoglucomutase
- Uncharacterized protein YhfW
- Phosphopentomutase
- Bifunctional NAD
- Esterase YqiA
Sequence:
MLKPDNLPVTFGKNDVEIIARETLYRGFFSLDLYRFRHRLFNGQMSHEVRREIFERGHAAVLLPFDPVRDEVVLIEQIRIAAYDTSETPWLLEMVAGMIEEGESVEDVARREAIEEAGLIVKRTKPVLSFLASPGGTSERSSIMVGEVDATTASGIHGLADENEDIRVHVVSREQAYQWVEEGKIDNAASVIALQWLQLHHQALKNEWA
Protein: Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF) (P27352)
Organism: Homo sapiens (Human)
Function: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Subcellular location: Secreted.
Interaction partners:
- Cubilin
- Protein amnionless
- Potassium-transporting ATPase subunit beta
- E3 ubiquitin-protein ligase CBL
- Low-density lipoprotein receptor-related protein 2
- Transcobalamin-1
- Gastric triacylglycerol lipase
- Potassium-transporting ATPase alpha chain 1
- Complement C1r subcomponent
- Trefoil factor 2
Sequence:
MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
Protein: dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) (Pyruvate dehydrogenase complex component E2) (Q7KTK9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILIQGGTKDVPVGQLLCIIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAPAAAAPPPAPAAAPAAAGTGRVYASPMAKRLAEAQQLRLQGKGSGVHGSIKSGDLAGQKAAAKPAAAAPAKAPRAAGARYEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDKLLKFRAKVNKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAWMDTVIRKYDDVDVSVAVSTDKGLITPIVFNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQFAAVINPPQSCILAIGTTTKQLVADPDSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL
Protein: NADH kinase (AtNADK-3) (EC 2.7.1.86) (Q500Y9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphorylates specifically NADH. Can phosphorylate NAD with a 100-fold decrease in efficiency compared to NADH. Prefers ATP as nucleoside triphosphate substrate. Can also utilize UTP, GTP and CTP. Key source of the cellular reductant NADPH which is an important antioxidant factor.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15347288}.
Interaction partners:
- NAD
- NAD kinase 2, chloroplastic
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Nudix hydrolase 19, chloroplastic
- Glutamine-dependent NAD
- NAD-dependent protein deacylase SRT2
- NAD-dependent protein deacetylase SRT1
- Alkaline-phosphatase-like family protein
- UDP-galactose/UDP-glucose transporter 1
- Probable inactive nicotinamidase At3g16190
Sequence:
MAIRKLLLLLKPIDPYPFLQTEGASLIKNPQVLQYLESRCKVHKNAIKFCQEILSKKPVEWKPISRNDLSHPIRDVDMVITVGGDGTLLHASHFIDDSVPVLGVNSDPTQAHEVEELSDQFDASRSTGHLCAATVENFEQVLDDILFGRVVPAKVSRISLKLNSETLLSHALNDILIAQPCPAAVSRFSFKIKNKDGASSPKTVNCRSSGLRICTAAGSTAAMQSAGGFVMPMLSRDLQFMVREPISPGSTASLMHSTFKPDQFMDVNWYSDHGTIYIDGCQVQHSVQLGDTIEISSDAPVLNVFLSHGISQIRSRY
Protein: Sucrase isomaltase (F8VQM5)
Organism: Mus musculus (Mouse)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004655}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004655}.
Interaction partners:
- Pancreatic alpha-amylase 2a5
- Alpha-amylase 1
- Alpha-galactosidase A
- Sucrase-isomaltase, intestinal
- Neutral alpha-glucosidase C
- Lysosomal alpha-glucosidase
- Hexokinase-3
- Hexokinase-2
- Hexokinase HKDC1
- Hexokinase-1
Sequence:
MAKKKFSGLEISLIVLFIIVTIIAIALVVVLATKVPAVEEVKSPTSTPSPGRCPPEQGEPLNERINCIPEQHPTKAKCEERGCCWRPWNNTIIPWCFFADNHGYTAASVTNDNSGLKATLSRIPSPTLFGEDIKSVLLTTQSQTRNRFRFKLTDPNNKRYEVPHQFVKDGNGIPAADTLYDVKVSENPFSIKVIRKSNNKVLFDTSIGPLVYSNQYLQISTRLPSEYIYGFGEHIHKRFRHDLYWKTWPIFTRDEIPGDNNHNLYGHQTFFMGIEDNSGKSYGVFLMNSNAMEVFIQPTPIITYRVTGGVLDFYIFLGDTPEQVVQQYQELIGRPAMPAYWNLGFQLSRWNYVSLDKVKEVVRRNREAGIPYDAQVTDIDYMEDKKDFTYDEVAFKGLPEFAQDLHNHGQKYIIILDPAISINKRANGAEYQTYVRGNEQNVWVKESDGTTSLIGEVWPGLTVYPDFTNPRTWEWWANECNLFHQQVEYDGLWIDMNEVSSFIHGSQKGCAPNLLNYPPFTPGILDKIMYSKTLCMDAVQHWGNQYDVHSLYGYSMAIATEKAVEKVFPNKRSFILTRSTFAGSGHHAAHWLGDNTASWEQMEWSITGMLEFGMFGMPLVGADICGFLANTTEELCRRWMQLGAFYPFSRNHNAEGYAEQDPAFWGADSLLVNTSRHYLTIRYTLLPFLYTLFYRAHAFGETVARPFLHEFYEDPNSWIEDTQFLWGPALLITPVLRPETKYVSAYIPDATWYDYETGEKRPWRKQRVDMYLPEDKIGLHLRGGYIIPTQQPDVTTTASRKNPLGLIVALDENQAAKGELFWDDGESKDTIEKKIYILYEFSVSNNNLIVNCTHSSYPEGNTLVFKTIKVLGLSATVTAVTVGENDQQMNPHLAFTFDAFNKILSITDLTFNLGKTFIVRWTTQSFSDNEKFTCYPDVGTATEKTCVERGCIWEPVSGLANVPPCYFPSNHNPYLLTSTQKLATGITAELQLNPASARIKLPSNPISTLRVEVKYHKNDMLQFKIYDAHHKRYEVPVPLNIPDTPTSSEENRLYDVEIKENPFGIQVRRRSTGKLIWDSCLPGFAFNDQFIQISTRLPSQYLYGFGEAEHTAFKRNLNWHTWGMFTRDQPPGYKLNSYGFHPYYMALEDEGNAHGVLLQNSNGMDVTFQPTPALTYRTIGGILDFYMFLGPTPEGATKQYHEVIGFPVMPPYWALGFQLCRYGYRNTSEIEQLYNDMKAAQIPYDVQYTDINYMERQLDFTIGERFKTLPQFVEKIRKEGMKYIVILDPAISGNETQPYPAFERGIQKDVFVKWPNTNDICWAKVWPDLPNITIDETITEDEAVNASRAHVAFPDFFRNSTSEWWTREIYDFYNEKMKFDGLWIDMNEPSSFVNGTVTNKCRNDTLNYPPYFPELTKRNEGLHFRTMCMETEHILSDGSSVLHYDVHNLYGWSQVKPTLDALRNTTGLRGIVISRSTYPTAGRWGGHWLGDNYANWENLEKSLIGMLEFNLFGIPYVGADICGFFNDSEYHLCARWMQVGAFYPYSRNHNIQFTRRQDPVSWNETFAQMSKKVLEIRYTLLPYFYTQMHEAHIHGGTVIRPLMHEFFDDKETWEIYKQFLWGPAFMVTPVIGPFQTAVNGYVPKARWFDYHTGEDIKVRGKLQTFSAPFDTINLHVRGGYILPCQEPAQNTYYSRQKYMKLIVAADDNQTAKGTLFWDDGESIDTYEKNQYTLIEFNLNQKNLTSTVLKDGYRNKSEMKLGSIYVWGKGTTSISQVNLTYGGNEQQLSFTQDEAKEILTIDLKNVTVTLDEPIQISWS
Protein: CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Q18224)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, P-body {ECO:0000256|ARBA:ARBA00004201}.
Interaction partners:
- Not3 domain-containing protein
- CCR4-NOT transcription complex subunit let-711
- CCR4-NOT transcription complex subunit 7
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- CCR4-NOT transcription complex subunit 4
- CCR4-NOT transcription complex subunit 11
- poly
- mRNA transport homolog 4
- Endonuclease/exonuclease/phosphatase domain-containing protein
Sequence:
MNDARASPATQAQQTAVPSSANLDINTDEIMQWIIDLRDPPKREAALLELSKKRDSVPDLPIWLWHSFGTMSALLQEVVAIYPAIMPANLTAAQSNRVCNALALMQCVASHRDTRGPFLHAHIPLYLYPFLHTTKVSRSFEYLRLTSLGVIGALVKTDDKEQLLIVINFLLSTEIIPLCLRIMEQGTELSKTVATFILQKILLDDTGLLYICQTYERFSHVVLILGKMVMKLTREPSVRLLKHVVRCYSRLSDNPTLTIDAPRGQGAAPGQIVKMRASLALKQCLPDQLKDLTFKSLLKEDPSTMNWLRQLLTTLEIDGTILHDEELMPK
Protein: Target of wingless, isoform C (Target of wingless, isoform D) (A8JNM0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGCGQSKIHLYPRKSKSKANGKKGGHADSDAETDEDEGHIEDAEKAQQRDREKHDESEELSNKDIQESDEDVAVSLLRAKNLSLLQSQEISSSQQNFFRMLDKKIDEGPDYDSASETEIALEEARLNALRQHWESASITASICSSASRSLQTTPIRQVQVPLKQPPRGAGLLIQPSSASAVTASTSSSSSSTIVALPTTEYLPQHVLTGRQVVQQQQQQQQQQAAVLYQQQQQQLILLPQLDPNVVNTSTAAAAAQLVQLQQQHQQQQQQLQLQQQQQLQLNQQQQQQLYQQQQQQYLLTLPAGSKPQSVSPKRLIYGGPAATTLLCATGIKCNAPETYEPPTAPHSQIQQQQPPPPPPGAYYGEMMHGVQAAPAAEYKFPPAISVQRLAPQVQRQLRETQELIKDSCPQLYAAGYGSPGPPIRNPSRNPTRTRPTLETQFSQELS
Protein: Macrophage-capping protein (Actin regulatory protein CAP-G) (Actin-capping protein GCAP39) (Myc basic motif homolog 1) (P24452)
Organism: Mus musculus (Mouse)
Function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+).
Subcellular location: Nucleus {ECO:0000269|PubMed:8293478}. Cytoplasm {ECO:0000269|PubMed:8293478}. Melanosome {ECO:0000250|UniProtKB:P40121}. Cell projection, lamellipodium. Cell projection, ruffle. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000269|PubMed:8293478}.
Interaction partners:
- Condensin complex subunit 1
Sequence:
MYTPIPQSGSPFPASVQDPGLHIWRVEKLKPVPIARESHGIFFSGDSYLVLHNGPEEASHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYYREGGVESAFHKTTSGARGAAIRKLYQVKGKKNIRATERPLSWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIITDGEEPAEMIQVLGPKPALKEGNPEEDITADQTRPNAQAAALYKVSDATGQMNLTKVADSSPFASELLIPDDCFVLDNGLCAQIYIWKGRKANEKERQAALQVADGFISRMRYSPNTQVEILPQGRESPIFKQFFKNWK
Protein: Protein Turandot B (Q9VDH4)
Organism: Drosophila melanogaster (Fruit fly)
Function: A humoral factor that may play a role in stress tolerance.
Subcellular location: Secreted {ECO:0000269|PubMed:11409894, ECO:0000305}.
Interaction partners:
Sequence:
MNFKTSLICFALLLIGTLCSAYSNQERQRDSRRVAEIMRTSWDDNTKIKRIQELLTIYNRMAPSLRPDERARMDRFISGYTGEIMVDGVPSQGGARRIFKKILSPAAKSVATGFFTELGASLASILTSWFPANTERNH
Protein: Homeobox protein rough (P10181)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk. Repression of expression in R8 photoreceptor by senseless (sens) is an essential mechanism of R8 cell fate determination.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:1974228}. Note=Restricted to nuclei in the developing retina.
Interaction partners:
Sequence:
MQRHKVEIGSPDGSPGIKRSDSLDPIANTTILSVPQRPSSPRQFFERLYGHLETRSSENGEIDVGTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSLAAYPAYDFYGHAKDYPQHPSQQHQQHHHHHHHPPQLVHQKLSYVSPPPAIAAGGAANPVLPHAFPAGFPSDPHFSAGFSAFLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDKRIEKAQIDQHYRNFVVANGFMSSIMGQAATTMPPGGVTGGVAVGVGLNYYAAAATPAALPKDNTQDANFIDIDDQFQRQQQQKQQQQQQQQRRRETTTPINIC
Protein: Protein phosphatase 2C 53 (OsPP2C53) (EC 3.1.3.16) (ABI1-like protein 2) (OsABI-LIKE2) (OsABIL2) (Q6L4R7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Protein phosphatase that acts as negative regulator of abscisic acid (ABA) signaling. Involved in the regulation of root architecture development and drought resistance. Can dephosphorylate SAPK8 and SAPK10 in vitro. Together with PYL10, SAPK8 and SAPK10, may form an ABA signaling module involved in stress response.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:26362328, ECO:0000269|PubMed:26491145}. Nucleus {ECO:0000269|PubMed:26362328, ECO:0000269|PubMed:26491145}. Note=Treatment with abscisic acid (ABA) reduces the nuclear localization and enhances the cytosolic localization. {ECO:0000269|PubMed:26491145}.
Interaction partners:
- Abscisic acid receptor PYL10
- Abscisic acid receptor PYL9
- Os02g0226801 protein
- Os01g0827800 protein
- Os03g0297600 protein
- Os05g0473000 protein
- Serine/threonine-protein kinase SAPK10
- Serine/threonine-protein kinase SAPK8
- Serine/threonine-protein kinase SAPK9
- Serine/threonine-protein kinase SAPK2
Sequence:
MEDLALPAAPPAPTLSFTLLAAAAAVAEAMEEALGAALPPLTAPVPAPGDDSACGSPCSVASDCSSVASADFEGFAELGTSLLAGPAVLFDDLTAASVAVAEAAEPRAVGATARSVFAMDCVPLWGLESICGRRPEMEDDYAVVPRFFDLPLWMVAGDAAVDGLDRASFRLPAHFFAVYDGHGGVQVANYCRKRIHAVLTEELRRAEDDACGSDLSGLESKKLWEKAFVDCFSRVDAEVGGNAASGAPPVAPDTVGSTAVVAVVCSSHVIVANCGDSRAVLCRGKQPLPLSLDHKPNREDEYARIEALGGKVIQWNGYRVLGVLAMSRSIGDKYLKPYIIPVPEVTVVARAKDDDCLILASDGLWDVMSNEEVCDAARKRILLWHKKNAATASTSSAQISGDSSDPAAQAAADYLSKLALQKGSKDNITVVVIDLKAHRKFKSKA
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q8UWF3)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
- Mothers against decapentaplegic homolog 3
- SMAD specific E3 ubiquitin protein ligase 2.
- TGF-beta receptor type-1
- Transforming growth factor beta-1 proprotein
- Activin receptor type-1
- Homeobox protein AKR
- Receptor protein serine/threonine kinase
- Forkhead box O3
- Fork-head domain-containing protein.
- Zinc finger FYVE domain-containing protein
Sequence:
MSSILPFTPPVVKRLLGWKKSAGGSAGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPSTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
Protein: Glutathione S transferase O2, isoform A (EC 1.8.5.1, EC 2.5.1.18) (Glutathione S-transferase omega class) (Q9VSL5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- glutathione transferase
- Glutathione S transferase T2
- Glutathione S transferase O1
- Glutathione S transferase T1
- GH16740p
- Glutathione S-transferase S1
- Probable maleylacetoacetate isomerase 2
Sequence:
MALPQKHFKRGSTKPELPEDGVPRFFSMAFCPFSHRVRLMLAAKHIEHHKIYVDLIEKPEWYKDFSPLGKVPALQLTGVKDQPTLVESLIIAEYLDQQYPQTRLFPTDPLQKALDKILIERFAPVVSAIYPVLTCNPNAPKDAIPNFENALDVFEVELGKRGTPYFAGQHIGIVDYMIWPWFERFPSMKINTEQKYELDTKRFEKLLKWRDLMTQDEVVQKTALDVQLHAEFQKSKTLGNPQYDIAFKGTP
Protein: DIMBOA UDP-glucosyltransferase BX9 (EC 2.4.1.202) (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase BX9) (Protein BENZOXAZINLESS 9) (B4G072)
Organism: Zea mays (Maize)
Function: Glucosyltransferase involved in the last step of benzoxazinoid glucoside biosynthesis. Catalyzes the glucosylation of hydroxamic acids utilizing UDP-glucose as glucose doner, reducing the toxicity of these natural insecticides for storage. Can use DIMBOA and DIBOA as substrates, HMBOA (2-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) and HBOA (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one) with a lower efficiency, but not indole acetic acid or quercitin.
Interaction partners:
- DIBOA-glucoside dioxygenase BX6
- Benzoxazinone synthesis5
- UDP-glycosyltransferase 76C1
- Glycosyltransferase
- O-methyltransferase ZRP4
- TRIBOA-glucoside O-methyltransferase BX7
- Cytochrome P450 71C3
- indole-2-monooxygenase
- Benzoxazinone synthesis2
- Indole-3-glycerol phosphate lyase, chloroplastic
Sequence:
MASSRTGAGAGGRVVVFPFPFQGHFNPVMRLARALHARGLAITVFHSGALDPADYPADYRFVPVTVEADPKLLASEDIAAIVTTLNASCDAPFRARLSALLAAEGRDSVRCVFTDVSWNAVLTASSDLGVPALGMMTASAASLRDYMAYRTLIDKGYLPVKEERKEDPVPELPPYLVKDLLRVDTSDLEEFAELLARTVTAARRASGLIFNTFPLIETDTLAEIHKALSVPVFAVAPLNKLVPTATASLHGVVQADRGCLQWLDTQQPGSVLYVSFGSMAAMDPHEFVELAWGLADSKRPFVWVVRPNLIRGFESGALPDGVEDEVRGRGIVVAWAPQEEVLAHPAVGGFLTHNGWNSTVEAISEGVPMVCCPRHGDQFGNMRYVCDVWKVGTELVGEQLERGQVKAAIDRLFGTKEGEEIKERMKEFKIAAAKGIGIGVDVDETASPRTDLTDLVDLIKSF