Protein: Putative neurobeachin homolog (Suppressor enhancer of lin-12) (Q19317)
Organism: Caenorhabditis elegans
Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17215302}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17215302}.
Interaction partners:
- Uncharacterized protein.
- RNA helicase
- Protein male abnormal 21
Sequence:
MEISETSHNESGPPVQENGIVEIPVEEGEEVNDEESNMETVDLGLDDSAADASSPSVFKNIDDEAPGDPSDAAKKEEDSEEIVVPSVLAPTPSQEVSPPNAIESLPPLPEGKELELEDDVTSSLPRLLSKTTLIHSNEEGADETIQRLVTVLHSNSPNTDRTQVVDNLFNLLVGGHFDQESKFVIEDAANVDHMLTLLSHCDYDLQNEIWSLFLAVMKKSNRNLEACTRVGLISKVLDILPEAPPLLADLLVQIIAALVAYSINVKQTKHLLRALKSTKEQWPPNSLKLLHVLKEMPQHDSADVFFSFPGKDQSGIILPPIKTMPYQQGWTFATWLRMEPLNSVTFEKEQPVLYSFRTSKGVGYSCHFTGNCLVVNVEKTKGKEQSRCVRAELGARKWHHIAIAHCYSRWGRSDIKCFIDGQLAETIELSWVVTSATNWDRCSIGVSADGTANSAFCGQMGAMYLFAEALTLQQANSLFCLGPVYQSTFKHDSETSLPEGYKKHLFDGHLHSSLVFAYCPKNCHGQLCLYTPPKTAASTYFVQIPHAVMKEGVEVITTHSIHKSLQSVGGIQILLPLFAQIDLPSSNDNSIDGEVCQTLLSLIALLLSSSQSSQQQLFHSKGFLIISSCLQKASPSHLSMKVLEQLIHIAKFLLRCPAGGPLLKHLFDYILFNPKLWIRARPEVQVHLYQYLATDFLANNNFSQMLRRVPTVIEMCHTLKHFYWLALPQTVSDYTIEERPENFATADIVAIRSSILTFINRIIIASAGPEEEERVRDQEVHTLLNLLATVREDDNLYDVLALVTRLLAEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKTESMGNQNLFSLIGERLLSHKKVLSLPTYNVLLEILVEQMTPTFTYACHQPAQPEWKFENPHLLKVIAHVISQCEESENIVQIKKCFLIDIINLCRESKENRRTILQMSVWQDWLIGLAYVFHTTESQNEVSELVWEAFSILLHHALRNEYGGWRVWVDTLAIAHSKVSFEKFKRKLAEAKIKAERSESGGEEAKMEPTPIYRAPEFAWSDVHVRLLADLLSGIERVVDEWKVAECGISDQCNASENQVFVGNVVHVVSQLSDSLIMACGGLLPLLASATAPNNDMEIVDPCQQQLPISVSAGFLMRFARLVDTFVLASGVSFSELEQEKNMPAGGVLRQSLRISATVTVRHILASRIQQPDTPRYETNSTKKNQCIMEFVREALEKRSPDGLENVERLVQDSDITRIKGVVYRDMVEENRQAQFLALSVIYLVSVLMVSRYRDILEPPSSPSPFFDSTTQKQENSENVNSETSPENGSNGKLANGGDNLSIKNGIESNGNDGEEEENGEEGQGDDGGRIAAIKVANADMKRGDGNEYDEEELSKMHQSNGRRPSTMMPVQQTAERRAYLTTKLQTALETCAPLLREMMSDFRGYLQKTLLGTHGQEIMNDTKVLETLRNRNASVIELVMLLCSQEWQTSLQKHAGLAFIELVNEGRLMAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLAARHEEYGRCDLLIASGRLRDSINATRLLEKMSAILSDQDDSKSGTQFWKLDVWEDDSRRRKRFVPNAYGSRHEEANLPEGEKNEEPEISEQEKIRKVLKGLFSKRQNSSGSHELVDESDIDKWAQEVDPTPSSQSACFSTTAKLIAPGVVVPGTLSVTANDLFFDANESDPNYKKQCAQVLRYCEALHARWNLQEIRAIFLRRYLLQNTALELFLASRTAIMFAFDSEDAVKKVVYQLPRVGVGVKYGLPQSRKTSLMTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKPIGALSEARRKFFNDRYTSWDDDQVPAFHYGTHYSTPAFTLNWLLRVEPFASMFINLHDGKFDHPDRITHSIKDSWDRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTPVDDVVLPPWAESPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVTPKMAETPGQVAAIEQQILSFGQTPSQLLTEAHPPRHSIMSMAPTMFRRHDEDLCMMMKYISNSPVVYLAANTFHQLPQPTVVGVAQNLVFSLNKWDNSYSYGASQRSALSMDPSNAEGQVSLPLTADAQLASAASTTPVARRHLGDAFDQRLTVQCSNFVTTTDSKFIFACGYPDYSFRIVDTDSGRVRQAVYGHGDVVTCIARSETSLFSDCYVVTGSMDCTVVLWHWNGTTGFIAGEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILIHTTSSDLLRRIRGHGIVTQLSMSRECILLSLFDSKRMVTYSATAKKLDEVLVDDKIECVTVTRDGEFAVTGAVNGRINIWRMFPLTKLYTYQPLNSAVRSVAVVASHRFILGGLDSGAIVVFNADFNRWHYEYKHRYIQNTSAAKPVQQSPQK