wanglab/gogpt-training-data huggingface dataset:
Protein: Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (Q6PB44)
Organism: Mus musculus (Mouse)
Function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Endosome {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}.
Interaction partners:
- GRB2-related adaptor protein 2
- Ubiquitin-associated protein 1
- Signal transducing adapter molecule 2
- Charged multivesicular body protein 4b
- Transmembrane 9 superfamily member 1
- Charged multivesicular body protein 4c
- Magnesium-dependent phosphatase 1
- Zinc finger FYVE domain-containing protein 16
- Zinc finger FYVE domain-containing protein
- Hepatocyte growth factor-regulated tyrosine kinase substrate
Sequence:
MEAVPRMPMIWLDLKEAGDFHFQSAVKKFVLKNYGENPEAYNEELKKLELLRQNAIRVARDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVAVTWTEIFSGKSVSHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAFSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFAMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMLAKIEDKNEVLDQFMDSMQLDPETVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELQEQKLQETLGQAGAGPGPSVAKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDNVLRALTEANVQYAAVRRVLSELDQKWNSTLQTLVASYEAYEDLMKKSQEGKDFYADLESKVATLLERAQSICRAQEAARQQLLDRELKKKAPPPRPTAPKPLLSRREEGEAVEAGDTPEELRSLPPDMMVGPRLPDPFLGTTAPLHFSPGPFPSSTGPATHYLSGPLPPGTYSGPTQLMQPRAAVPMAPATVLYPAPAYTSELGLVPRSSPQHGIVSSPYAGVGPPQPVVGLPSAPPPQLSGPELAMTVRPATTTVDSVQAPISSHTAPRPNPTPALPQPCFPVPQPVPQSVPQPQPLPVPYTYSIGTKQPLPAPYTYSIGTKQHLTGPLPQHQFPPGIPTGFPVPRTGPQAQAQPQPQPQPQPQPQPQPQPQPQPQSQSQPQPQPQPQPQRPAFGPQPTQQPLPFQHPHLFPSQAPGILPPPPPTPYHFTPQPGVLGQPPPTLHTQLYPGPSQDPLPPHSGALPFPSPGPPHPHPTLAYGPAPSPRPLGPQATPVSIRGPPPASQPTPSPHLVPSPAPSPGPGPVPSRPPTAEPPPCLRRGAAAADLLSSSPESQHGGTQPPGGGQPLLQPTKVDAAEGRRPQALRLIEQDPYEHPERLQQLQQELEAFRGQLGDAGALDAIWRELQEAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSVALSSIRTTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPGNLLRFIQEVHAHYLHQRPLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLKFCHEALVRHVEQVLQRHGVPPPGKPVASVNISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPLGGLDSPAASLPGLVEPPGLPPASLPESTPVPSSSPPPLSSPLPEAPQPEEEPSVPEAPSLGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKQNFLQAHNGQGLRAAQPTDDPLSLLDPLWTLNKT
Protein: Dguok protein (B5DEP0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMYQEPARWSYTFQTLSFMSRLKVQLEPTPGRLLQADTSVRVFERSVYSDRYIFAKNLFENGSLSDVEWHIYQDWHSFLLQEFEDRLLLHGFIYLQASPQVCMERLCQRGREEEKGIELAYLKQLHGQHEDWFINKTTKLHFEALRHVPVLVLNISEDFSENAAKQEELMGQVNTFMRNL
Protein: Meiotically up-regulated gene 150 protein (O94546)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MASLFIIMDKRFAVFASSDKPNNCSRKNMFFLKNIIVLSNYLYLLYKAWIVCTTISLCCDFPLFNFLFIAIPYFTEILYNDSSLLWFLFVSLCFITLSFQSLEI
Protein: Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] (Q9BY44)
Organism: Homo sapiens (Human)
Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 2 subunit 3
- Eukaryotic translation initiation factor 2 subunit 2
- Interferon-induced, double-stranded RNA-activated protein kinase
- Eukaryotic translation initiation factor 5B
- Small ribosomal subunit protein eS6
- eIF-2-alpha kinase GCN2
- Eukaryotic translation initiation factor 2-alpha kinase 3
- Small ribosomal subunit protein eS19
Sequence:
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVNIISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGIFPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPLSKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI
Protein: DEAD-box ATP-dependent RNA helicase 30 (EC 3.6.4.13) (Q8W4R3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ypt/Rab-GAP domain of gyp1p superfamily protein
- Pescadillo homolog
- D-lactate dehydrogenase
- Probable rRNA-processing protein EBP2 homolog
- Peroxidase 33
- Nuclear protein-like
Sequence:
MSSYDRRFADPNSYRQRSGAPVGSSQPMDPSAAPYNPRYTGGGGGYGPSPVMAGDNSGYNRYPSFQPPSGGFSVGRGGGRGGYGQYGDRNGGGNWGGGGGRGGSSKRELDSVSLPKQNFGNLVHFEKNFYVESPTVQAMTEQDVAMYRTERDISVEGRDVPKPMKMFQDANFPDNILEAIAKLGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTLAYLLPALVHVSAQPRLGQDDGPIVLILAPTRELAVQIQEESRKFGLRSGVRSTCIYGGAPKGPQIRDLRRGVEIVIATPGRLIDMLECQHTNLKRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLLWSATWPREVETLARQFLRDPYKAIIGSTDLKANQSINQVIEIVPTPEKYNRLLTLLKQLMDGSKILIFVETKRGCDQVTRQLRMDGWPALAIHGDKTQSERDRVLAEFKSGRSPIMTATDVAARGLDVKDIKCVVNYDFPNTLEDYIHRIGRTGRAGAKGMAFTFFTHDNAKFARELVKILQEAGQVVPPTLSALVRSSGSGYGGSGGGRNFRPRGGGRGGGFGDKRSRSTSNFVPHGGKRTW
Protein: Uncharacterized protein (Q54JS9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MTMHGILPADDIDYINDTPTIQEYKKLKRVMKIMTNFYVGGSATKLQQAEYFEDELKKVTTDQNMIEAQLNVMKKFPIHPKRREYEEELQEENDKLVSMKKKFSTKAEEYRKLYVWSNGIVQVTKWLEDGLDDYCVNHLKMDLGFEVIPNEPLSKEKYSAYKEGLDEITYNLQESQDFFSASLDGRLRQYHRMEKEIIEAQIEAVKSFPEDNPRRSHIIAELEQDLEYVSKNMVEDPSAMAKRVRMLEMHSDFFKVLRWYREKMKALGDEYGIVDTDKRTEEEKIKSAMSTQVEFMTNFTPENTPELEELKKLNLLH
Protein: EKC/KEOPS complex subunit BUD32 (EC 3.6.-.-) (Atypical serine/threonine protein kinase BUD32) (EC 2.7.11.1) (Bud site selection protein 32) (Low-dye-binding protein 14) (piD261) (P53323)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Chromosome, telomere {ECO:0000269|PubMed:14562095}.
Interaction partners:
- EKC/KEOPS complex subunit GON7
- tRNA N6-adenosine threonylcarbamoyltransferase
- EKC/KEOPS complex subunit CGI121
- EKC/KEOPS complex subunit PCC1
- tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
- Threonylcarbamoyl-AMP synthase
- Monothiol glutaredoxin-4
- 18S rRNA aminocarboxypropyltransferase
- Monothiol glutaredoxin-3
- Cell division control protein 13
Sequence:
MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEVRLRGRKRSMLG
Protein: Peroxin-19 (Q8T9H4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSEEKKNGDELNDLLDSALQDFDKSGAGDQKEPSASSDVATTAGAEGSEDPDAFFIEQAKVLADRMNTLFGGPDTPSGDIPPLPQDPDQIMAGFKKMAEAAALTLSGENSATDEDVSKYSDSISQALKGLQEGSENLAAPASENDIASMFGSLNLEGAGEGDGNMFLPFMEGMMQSLLSAEILLPSIRELLEKYPKYLEENDAKLSAEDKERYQKQMELYKVIEGHLQSEKTEDSAAVKREKFRVVLDDMRKLQDYGQPPPEILAETGGDLPFGDPTAGVAAGGPGPQCPTM
Protein: Ephexin1 (Q5I1Y9)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MTTDSWRNLIEHIGLLYQEYRDKSTRQEIETRRLQDSQTDPEESSPSEETPPETEPASTPESKAAPQINLLRNSNSRFNLWQDLPEIRSSGILSILQPDEIKLQEAMFELVTSEASYCKSLNLLVSHFMENERLKKILHQSEAHILFSNVLDVKAVSERFLLDLERRVEENIVISDVCDIVYQHTVDHFSVYITYVSNQTYQERTYKQLLQDKPAFREVITQLELDPMCRGLSFSSFLILPFQRITRLKLLVQNILKKVEEKSERETTALEAHKELETVVKACNEGVRKMSRTEQMISIQKKLEFKIKSVPIISHSRWLLKQGELQQMNGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDHGQSLANVFILRLLENADDREASYMLKASSQSEMKRWMISLAPNRRTKFVSFTSRLSDCPQIQCVHPYVAQQPDELSLELADVLNILDKTDDGWIFGERLHDQERGWFPSSIGEEILNPKIRAQNLKECFRVHKSDDSQRRKLGSRNRQ
Protein: Sodium channel protein (Q9DF53)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
Interaction partners:
- Sodium channel regulatory subunit beta-3
- Sodium channel subunit beta-2
- Sodium channel, voltage-gated, type I, beta b.
- Sodium channel regulatory subunit beta-3
- Neurofascin homolog
- Neuron navigator 1
- Potassium voltage-gated channel subfamily A member 1
- Uncharacterized protein.
- Potassium voltage-gated channel subfamily A member 2
- Potassium channel, subfamily T, member 1.
Sequence:
MAAPLLAPPGPNSYKYFTRESLREIEKRIEEEKAKPPPKPDNSYRDDDDENKPKPNGDLEAGKSLPFIYGDIPPGMVATPLEDFDPFYINQKTFVVLNKGKTIFRFSATPALYMISPFNLARRIAIKILIHSVFSMFIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESAVKIIARGFCIDGFTFLRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPINITEMFPDVNGSRAFNWDEYILNETNFYFLPDQLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATMEEAERKEAEFKAMLEQLKKQQEDAQANAMATSAGTVSEDVVEDDGDGEGNLSCSSSEMSKLSSKSAKERRNRKKKWRQKEQDKEKGDSEKFVKSESDDGSRRRFRFPDNRLGRRSSIMNQSLLSIPGSPFPSRRNSKSSIFSRCKDGGSENEFADDEHSTVEEYDERRDSFLSPQRRSSYTGFYGKRNSTVDCNGVVSLIGPGPGGRLLPEPTTDLEIKKKLSGSLMVSVEQLNTSFGRKERANSVMSALTNTLVEELEESQRKCPPCWYKFANTFLIWECGPLWMSIKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTPQFEHVLSVGNLVFTGIFTAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAQDCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAASDDDGEMNNLQIAVIRIKKGIAWVKAKVRELVNIILGRKVTDEAKPLDDMYDRKLNCIANHTGVDISRDLDYQKNGNGTTSGIGSSVGKYMIDDDHMSFIHNPNLTVCVPIAVGESDFENLNTEDFSSESEAEGSKELDDISSSEGSTIDIKPEVEEAVVVETVEEYVDPEACWTEACIARYKCCDVPITEGWGKNWWFLRKTCYLIVEHNWFETLIIFMILLSSGALAFEDVYIEQRKTIRIILEYADMVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFAGKYYYCYNETEKAYFELDVVNNKSECFALIEQNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRRVEDQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKLQGMVFDFVTQQVFDISIMILICLNMVTMMVETDDQSQETENILYWINFIFIVAFTSEFVLKLFALRHYYFTNGWNIFDCVVVILSIVGMFLADLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKRESGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCEPTKENPGTSVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESADPLCEDDFESFYEIWEKFDPTASQFITFAKLGDFADTLEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGDLDMMRQQMEERFIAANPSKVSFEPITTTLRRKQEHMSAGVIQRAFRAHLIRKGFICKRLLSSSRLENGGTNQDKKEGTPSTASLPSYDSVTKPEKEKLEESDSKGKKGKNQKDVKESKF
Protein: TRAF-like family protein (Q9FWZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative DNA
- Probable serine/threonine-protein kinase PBL15
- Protein NRT1/ PTR FAMILY 4.6
- Diacylglycerol O-acyltransferase 1
Sequence:
MGASCSAPVSSTIKKNWRDHPPSSYSLKIHNFSQLEKTTSFSGHKYQSRLFSSGDITGNVKDNGSGFISMYVELDSSSLMESKPPTEVFAELRFFVYNKKQNKYFTKDVEIKRFDALKMVWGLPKGNECEFGVDVIVAPPLTNWEILSFHDEKLSYPKVTWSVKNFSQWKENECSKPNRFSIGGREWVLKLFPKGNSRAKGKYLSVFLYLADNETLKPDEKIFTQVVVRILNPLGSNHVASRLNYWHKGSNFGYGWCKFLSLDKIRKTYLDKEDTLMIEAEFEVVSATKFSTII
Protein: Histone-lysine N-methyltransferase EZ1 (OsiEZ1) (EC 2.1.1.356) (Q84UI6)
Organism: Oryza sativa subsp. indica (Rice)
Function: Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity). Involved in histone methylation and transcription regulation (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:14527713}.
Interaction partners:
Sequence:
MASSSSKASDSSSQRPKRPDQGPSGKDAAGLVVLHGKLAQLKRQVQSTRLAAIKERVEANRKALQVHTCALFDVAAAAEVASRGAEGGNALSRGAAEGHCRLVGWDSASGPGERELVHVQEENLVAGTLVLSSSGGSGASHRTVVQLAKLPVVDKIPPYTTWIFLDKNQRMADDQLVCRRRIYYDPIVNEALICSESDDDVPEPEEEKHVFTEGEDQLIWKATQDHGLSREVLNVLCQFVDATPSEIEERSEVLFEKYEKQSQSSYETDFQLFLGKTMDVALDSFDNLFCRRCLVFDCRLHGCSQNLVFPSEKQPYGHGLDENKRPCGDQRYLRRREVYQDTCNDDRNACTTYNTDSRSSSLKVSATILSESEDSNRDEDNIKSTSIVETSRSKITNSEYADKSVTPPPGDASETENVSPDMPLRTLGRRKISKHASKSNDHSPDKRQKIYSSPFPFAMSVLNKQSVPEIGETCPDSIESAVDQLPSLDDPNKKISTKDMCAGSTTNTTENTLRDNNNNLFISNKEHSISHWSALERDLYLKGIEIFGKNSCLIARNLLSGLKTCMEVASYMYNNGAAMAKRPLSGKSILGDFAEAEQGYMEQDLVARTRICRRKGRARKLKYTWKSAGHPTVRKRIGDGKQWYTQYNPCGCQQMCGKDCACVENGTCCEKYCGCSKSCKNRFRGCHCAKSQCRSRQCPCFAASRECDPDVCRNCWVSCGDGSLGEPLARGDGYQCGNMKLLLKQQQRILLGKSDVAGWGAFIKNPVNRNDYLGEYTGELISHREADKRGKIYDRANSSFLFDLNEQYVLDAYRKGDKLKFANHSSNPNCYAKVMLVAGDHRVGIYAKDRIEASEELFYDYRYGPDQAPAWARRPEGSKKDEASVSHHRAHKVAR
Protein: MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) (D3ZEN0)
Organism: Rattus norvegicus (Rat)
Function: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q3TN34}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3TN34}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q3TN34}. Recycling endosome {ECO:0000250|UniProtKB:Q3TN34}. Cell projection, neuron projection {ECO:0000269|PubMed:20008558}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3TN34}.
Interaction partners:
- Ras-related protein Rab-13
- Ras-related protein Rab-8A
- Ras-related protein Rab-8B
- Alpha-actinin-4
- Alpha-actinin-1
Sequence:
MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFNALRKENIYENNKLAFQVAEEQLGIPALLDAEDMVALKIPDRLSILTYVSQYYNYFHGRSPIGGMAGMKRPSSDSTEELSGKKKVPSQPAKLSSPVPTQRLPLSPARTNPVVQRNEGVSERPSPKAAPGTVGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCTHHSSEAVSVSPKLSNLASRQPGGGIADTRPIGVSQKVLETNGEATPLRARTAAWEHAGGNRAAKGFVQTELTPPATSRVHVGSPAGPRLPMSTVTTTSANSKATTHVTNSSPVGWSSSAQSSTGTSGSRPVVSPSALGAHLSVPQGQAASKGVKTQLNSSTDSSSTAPTPAWTSSSSRTQQAREKFFHNLSPAPAPAPASSSSSHASRVPTVVTAPSGKVSPLVNTSTSKVPSATVVTVPTSKASTVVTAPTSKAPTVVTVPISKAPTVVTAPTSKVSTVVTVPTSKASTVVTAPTSKASTVVTVPTGRGHVVVNTSASKVSGVVDNPAQESSREQALSVLRKALPGLTRAGSQAPSRSSPATSSVLITLPKNEVPPKVPSAKLSHSTTQAFSPTPKMEPTAPLSVGSTSWTSVSLQAGKKSPGISPGIGKTSAVSRPQAEVKGTSGPGPTSQEGQEEGPEGWRARLKPVDKSIPSARALEQKEPVLAEPRAGDTPRKASSSSDSSIHITLTPIQQKRTPCLADSGSSLAAPSPPSRRKKLVVPPTLDVSADWLQPELKKQDDQTRSCKEKTATWGTRESSAILDNDLVSPDEAVTSPVRLHPNYISQEELQRQLQDIERQLDALELRGVELEKRLRAAEGDASEDGLMVDWFRLIHEKQLLLRRESELMYKSKDQCLEERQLDLQGELRRLMEKPEGLKSPQDRKREQELLNQYVNTVNDRSDIVDNLDEDRLREQEEDQMLESMIQNLGLQRKKSKSFLSKIWSSKSKSGQT
Protein: F-box/LRR protein (F4IIC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTILRSREIPSVSPKPLPKESDTEPSTPARTLEPELHRSPDETAPELGLVDEPTHTTRRRSLRLAHQFDGDDCVTEKEVSVDEKFLSLRSGKRVAKRGVDYGIEIESSKFDFDLKLGESASKTKRVCVDLVEETIVKNESEDSVDLEDKSSSGVLGDSLAEKWYVVEVENESNNKGKGIMEDSYGESDVICGQSYEKQSSSMGRRRYTREEKGKGIMQVEDVSSPVTVEIVEVDEEEMEIESLVNSEKPPDVSVTELAATMANVEQAQNRENSNEIGNDSRTQHFRDIAERIAHRFAHFDAQVEEEEDLSDKEGEQQVEDWPGPFSTAMKIIKDREEYTTPHVGIGVSNKERSSPTIWVPRSNFSFPPRKAPSLQELSLRVLVKNADAITSLDYVPDTLRVKLCQLLCDSRRMDLHFLDLLVQGSPTEICVPDCSWLTEEEFTECFKNCDTSNLMVLQLDQCGRCMPDYILPFTLARSPKVLPMLSTLSISGACRLSDVGLRQLVSSAPAITSINLNQCSLLTSSSIDMLSDSLGSVLRELYINECQNIDMKHILAALKKFEKLEVLSLADLPSVKGRFLKEFVTARGQTLKQLILTNSRKLSDSSIKVISENCPNLSVLDLANVCKLTDSSLGYLANGCQALEKLIFCRNPFSDEAVAAFVETAGGSLKELSLNNVKKVGHNTALALAKHSDKLQILDISWCREMSNDLLGYIVDNSSSLKVLKVFGCSQVTDVFVKGHSNPNVKILGVKMDPFLGHLSDN
Protein: Exoribonuclease II, mitochondrial (RNase II) (Ribonuclease II) (EC 3.1.13.1) (Processome-associated RNase) (Q1MTN7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for intron-independent turnover and processing of mitochondrial RNA. Participates in 3'-mtRNA processing where it hydrolyzes single-stranded RNA or partially double-stranded RNA with 3'-single-stranded tails.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- ATP-dependent RNA helicase suv3, mitochondrial
- Exosome complex component csl4
- Exosome complex component rrp42
- Exosome complex component rrp45
- Exosome complex component ski6
- Exosome complex component rrp43
- Exosome complex component rrp46
- Exosome complex component rrp40
- Exosome complex exonuclease dis3
- mRNA degradation protein pet127
Sequence:
MNYRQLFLLQNVNLESNYLLKRVCLSLKLSPCKLTRKFHHACPSSSKVLKYFRITGCLINFGKQPANDHHLWGHCGARLKHTQSDLIDRFKNANLKSVNEENLKKFFSELENHGNIRQWLKDKFEKDKRAAVCPTTTKSEEEKLENDFEYSFDLEDFSSENFRQYDRGDLLVFYRGSEGIELAACTGTNVWNYSNVLTSINENGTIKEFRTSRVLLRCPNVFKKLKEVQQPLSDVSVPSDVLPFTIKLLKKISQRAQDLSRSHRNEFLRILTEFNIPNKLDNSASFSDLLKFVYKTSKPSPYAKISLLHFLLTESKHFLISDHIFSEIQKVYFLPSSQNDSFDDVVACLRQKSTPYLSFIKKARHLIQVSRDKYKLPISTEEIKPVVYSQVTWTEFEKKLLRYLVQEMIAKSIQSLPNTHLCQVYKEVGLQTHERGLTSDQFAKFLTDIGVWASWQPPRLFQQEYSIAGLGTNPQLDAVYERECNHFKKFVKNELKDSLESQRVDLRHLKAFAFDSSSTKEIDDAISVEELGMSNSWLHIHVANPTSTVDIRSPLGTFAERNFQTIYHPNKIVYMLPLNITQKYWSLDSSSTAQRALTFSAKISKNGDILDYKVRPSFISSVIKYTPQQLDKALHSNRSIAKDIVSGPVDEETKGVSNDHMKDILRIYELSKQACFSRLQKFAFVIAQPTPTVELLPNNVPYNLGDLNHPVYWSSFPTISLNVSEGYSLAESVISECMILAGRVSSLFFQEHKLPGIFRGQPYPIMDGVRRKAFETLLSNRSSWGLVETKYSLSVMPLFESSHLASTPVSHFSLGLKDGYIQSTSPLRRFTDFFTHHQIQSVLLKTPKNTIPDGILRGKLNLYNQKEKSIKTIGRYINRFWALKYIERLPKVQKNIYHGYLMVSELSTPQVMLEELGVKAHIDILPDEAFRLANTRQAFTIKDVFPESNILLVALAT
Protein: C2 domain-containing protein (Q57Y23)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGKLQVCICAARNLHEQSAPCMPDPYCCVRLGDTTYKTKIVNNTCNPVWNQTLRFYVADENTAHLCVELWTTDVITDGVLGSICLPLSGLTMGIIQDSWYLLSHSPTNAELRIRLLACDFGKQPHPNQRWKITNDINNCSVLAADEKLSAAAPALMA
Protein: Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20) (O60641)
Organism: Homo sapiens (Human)
Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).
Subcellular location: Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Interaction partners:
- Epsin-2
- Epsin-3
- Vesicle-associated membrane protein 2
- Huntingtin-interacting protein 1-related protein
- Epidermal growth factor receptor substrate 15
- Clathrin heavy chain 1
- Clathrin heavy chain 2
- Intersectin-1
- Intersectin-2
- Endophilin-A1
Sequence:
MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSSGGAAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATASASASTTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATATTAPPALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL
Protein: Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) (Q8N5R6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAFRGPEPWVSASLLRQRLKAEEKTLDLEFEVLSVGFNEAGRYALRLSAENPLQVGSGAGVQLQVNDGDPFPACSAITDVIEQQEPGQSLTLTRSKFIFTLPKGFCKNDGQHDAQLHVEALRLDEPLGRAAQRVGEAIFPIYPRPDQPRMNPKAQDHEDLYRYCGNLALLRASTDPTARHCGSLAYSVAFHVHRGPQPPVSDSPPRAGQPELMSPEEPLIASQSTEPEIGHLSPSKKETIMVTLHGATNLPACKDGSEPWPYVVVKSTSEEKNNQSSKAVTSVTSEPTRAPIWGDTVNVEIQAEDAGQEDVILKVVDNRKKQELLSYKIPIKYLRVFHPYHFELVKPTESGKADEATAKTQLYATVVRKSSFIPRYIGCNHMALEIFLRGVNEPLANNPNPIVVIARVVPNYKEFKVSQANRDLASVGLPITPLSFPIPSMMNFDVPRVSQNGCPQLSKPGGPPEQPLWNQSFLFQGRDGATSFSEDTALVLEYYSSTSMKGSQPWTLNQPLGISVLPLKSRLYQKMLTGKGLDGLHVERLPIMDTSLKTINDEAPTVALSFQLLSSERPENFLTPNNSKALPTLDPKILDKKLRTIQESWSKDTVSSTMDLSTSTPREAEEEPLVPEMSHDTEMNNYRRAMQKMAEDILSLRRQASILEGENRILRSRLAQQEEEEGQGKASEAQNTVSMKQKLLLSELDMKKLRDRVQHLQNELIRKNDREKELLLLYQAQQPQAALLKQYQGKLQKMKALEETVRHQEKVIEKMERVLEDRLQDRSKPPPLNRQQGKPYTGFPMLSASGLPLGSMGENLPVELYSVLLAENAKLRTELDKNRHQQAPIILQQQALPDLLSGTSDKFNLLAKLEHAQSRILSLESQLEDSARRWGREKQDLATRLQEQEKGFRHPSNSIIIEQPSALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT
Protein: Jak1 protein (Q5FVF5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK