wanglab/gogpt-training-data huggingface dataset:
Protein: RE08174p (Q9VPL4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDKSTRPKRNRRHSRRAWPPEEELHPASRATKRLFTPDIKRMLKDWLIRRRENPYPSREEKKQLAAETGLTYTQICNWFANWRRKLKNSEREKAKKSWGHLIKNYNHNARGNVEQFSISSEDSIWEEEMHSCPAEDDEGDDNEEFSSHSTGSDGNANNEPSSPYKPILFVGSAGLTERISAQTGGKTKYKHQMMEKYMRDSSTAKTTSQQGTQLNKWLESAAKFTPDRNNYHIEWNMTRQKASSNSSCGQAIFTTDVSGAGRGGRWMLHHKDELEAAEALANLAFNCRQRWHHI
Protein: Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) (hTMEM175) (Q9BSA9)
Organism: Homo sapiens (Human)
Function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. May also act as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes. The potassium channel activity is however unclear as it was tested in non-physiological conditions for a lysosomal channel. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:32228865}; Multi-pass membrane protein {ECO:0000269|PubMed:32228865}. Lysosome membrane {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:31261387, ECO:0000269|PubMed:31658403, ECO:0000269|PubMed:32228865}; Multi-pass membrane protein {ECO:0000269|PubMed:32228865}.
Interaction partners:
- Cyclin-G-associated kinase
- Diacylglycerol kinase theta
- Alpha-synuclein
- Leucine-rich repeat serine/threonine-protein kinase 2
Sequence:
MSQPRTPEQALDTPGDCPPGRRDEDAGEGIQCSQRMLSFSDALLSIIATVMILPVTHTEISPEQQFDRSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLPYTFSLMVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQRSAHRALYRRHVLGIVLQGPALCFAAAIFSLFFVPLSYLLMVTVILLPYVSKVTGWCRDRLLGHREPSAHPVEVFSFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVKERFSGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSVWFGGREHVLMFAKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAFLLLRLLVGLALATLRVLRGLARPEHPPPAPTGQDDPQSQLLPAPC
Protein: FERM and PDZ domain containing 4 (A0A8I6ALA6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILFTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGTENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKAVEMTDSTLCPKEHRHLYIDNTYSSDELSQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTLGYERMLDENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVSEINQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHENKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPTVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKTPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLAEGEGKCPLSGNVPGKKQQGTKIAETEEDTKGKVGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGVEAPAMKAFPRGPGLGNREAEGKEDGTMEGEADDASGLGQGERFLSDMACVASAKDLDNPEDTDSPTCDHATKLPEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHLIPDASGKGGSYISPEERVAGHPNHGATFKELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTALTEPGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGNQAFGEAVSWRPADLRGGSLRTPPSQRALRHSSSILSGPVGLETFQEGTKGVVSLKYPGITEAQEASSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPMSHKDSKVYRTLPLRKLESSNWRCRGPFSYCFLNQGQDEDGDEDEEGEATLQVSCLYRPHITQGMPETSNSSLAVGLQKQGEELSRGTVLKDWTEDPDGPDDLDFSSLAFDARIARINALKANTYGMPDGFLEAQNDANELLCLVRATKAKREESRPEAYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPEEMLLAMSSSFQVLCCLTEACMRLVKVVNSETQRQEIVEKIDEVVINYICLLKAAEAATGKTTGDPSIGLSMRHSTTMAALVSTLTRSLKMLLNK
Protein: Ras-related protein Rap-2 (A0A0G2JTW1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057}.
Interaction partners:
- non-specific serine/threonine protein kinase
Sequence:
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSNEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ
Protein: Uncharacterized protein ycf76 (ORF85) (P0C472)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MKKILFSMFYSILVGEEPDSVFLKKEGKQNQVKMIWVAPSSCAKDLTISEGTGATFLFNFHSRVSYLFPRPFLRPRNMKWTNSFS
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q6AYQ9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Transducin beta-like protein 3
- WD repeat domain 36
Sequence:
MSRGPRLLLPAVLFLGLGGLVSSSGSSGVRKRGPLVTDKVFFDVRIGDKDVGRIVIGLFGKVVPRTVENFVTLATGEKGYGYKGSIFHRVIKDFMIQGGDFTARDGTGGMSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPAWLDGKHVVFGKVLDGMTVVHSIELQATDDHDRPLTDCTIVNSGKIDVKTPFVVEVPDW
Protein: Kinesin heavy chain 73, isoform C (EC 3.6.1.3) (A4UZI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSISKEMSTSMTGSMTRSKSRGDSLNLSARK
Protein: Zinc finger and BTB domain-containing protein 3 (Q9H5J0)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MLREFSKWGVEASPGKAWERKRSLLRGAVGRYRGATGGDLFWAPFPSWGTMEFPEHSQQLLQSLREQRSQGFLCDCTVMVGSTQFLAHRAVLASCSPFFQLFYKERELDKRDLVCIHNEIVTAPAFGLLLDFMYAGQLTLRGDTPVEDVLAAASYLHMNDIVKVCKRRLQARALAEADSTKKEEETNSQLPSLEFLSSTSRGTQPSLASAETSGHWGKGEWKGSAAPSPTVRPPDEPPMSSGADTTQPGMEVDAPHLRAPHPPVADVSLASPSSSTETIPTNYFSSGISAVSLEPLPSLDVGPESLRVVEPKDPGGPLQGFYPPASAPTSAPAPVSAPVPSQAPAPAEAELVQVKVEAIVISDEETDVSDEQPQGPERAFPSGGAVYGAQPSQPEAFEDPGAAGLEEVGPSDHFLPTDPHLPYHLLPGAGQYHRGLVTSPLPAPASLHEPLYLSSEYEAAPGSFGVFTEDVPTCKTCGKTFSCSYTLRRHATVHTRERPYECRYCLRSYTQSGDLYRHIRKAHNEDLAKRSKPDPEVGPLLGVQPLPGSPTADRQSSSGGGPPKDFVLAPKTNI
Protein: mRNA export factor GLE1 (Nucleoporin GLE1) (Q55FW7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.
Interaction partners:
- Nuclear pore protein
- Uncharacterized protein
- ATP-dependent RNA helicase ddx19
- WD40 repeat-containing protein
- Spore coat protein SP65
- Nuclear pore complex protein
- Nucleoporin 155
- Nucleoporin 133
- Nuclear pore complex protein nup54
- Nuclear pore complex protein nup85
Sequence:
MNKTSSNNISNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNRILSPFKRNNSKENGNGSVTITLEPLVSPFKLIKSNFKDDVHTNNINNNNNKIKRFLDEDNEFEITIPIRRSGNSINFNIGIVPSSNKKQQQQQQQQQKQKQKKKKTLSPLKKAPGIYSLKDLTIDSDSDSDSYSDNDDNEEYNIKLKSPIKNKIVNNNNNQQQQQKQKEKEEKEEKEKVEKDKKEKDKKKLILNSFQSELIINRVEREREIKINRIVEEKNKEIDDKWVEIKEYNQNQMIKERKEFHSQQIRLNNLIKKQHKKDIKEFSIKLKQAKQKHQSELSESLSLLNQLNKLEQQEIDRHNEELLKYELAIKEEKRKQQQLIERYEQKKREEKQRQLQQEQKEKQEKLEKEEKEKEQQEQQKQLLIKLAKEKEEKEKFEKEQQQQKEKELQKEKELLQQKEKEKEKEKLQQQQQQQQQQQQQQQQQLQQQQQQQNQQNNNLGYIKKDGIIFSLNENSKNFNDFKERSKEFDMIIKFINEKKSMLSREMVEFERQNSKLINIAINQISASQEQVNEKTNKLIKSIQDSQQSDYLKKSTILSIVKKSLSQVESQITFHNASSFPLALVLVRVGEKYPELIDCLLASLNEKCCYTVPYYVSPKENESQSSISKRMGYAFSNDIVGDNDKPIETEDEFHKRICGYLSLYCALILKSEQPHKSSSSSSSSSSSTMMFGFGTQIGNNNNNKLINKNLNIESSLRWLKDLVSLRPRRITSYLFVTFFTHLGNLLSKNQKSSLEFKIIVGKIVEENFFNQMNKPGTEGSFSRLKNLIEEYYKTGTFQQHEGVDF
Protein: Glutathione import ATP-binding protein GsiA (EC 7.4.2.10) (P75796)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Glutathione transport system permease protein GsiC
- Glutathione transport system permease protein GsiD
- Glutathione-binding protein GsiB
- Isoaspartyl peptidase
- Probable D,D-dipeptide transport system permease protein DdpC
- Oligopeptide transport system permease protein OppC
- Dipeptide transport system permease protein DppC
- Nickel transport system permease protein NikC
- Sulfate/thiosulfate import ATP-binding protein CysA
- Putrescine export system permease protein SapC
Sequence:
MPHSDELDAGNVLAVENLNIAFMQDQQKIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLLEQAGGLVQCDKMLLQRRSREVIELSEQNAAQMRHVRGADMAMIFQEPMTSLNPVFTVGEQIAESIRLHQNASREEAMVEAKRMLDQVRIPEAQTILSRYPHQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQKEMSMGVIFITHDMGVVAEIADRVLVMYQGEAVETGTVEQIFHAPQHPYTRALLAAVPQLGAMKGLDYPRRFPLISLEHPAKQAPPIEQKTVVDGEPVLRVRNLVTRFPLRSGLLNRVTREVHAVEKVSFDLWPGETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNGQRIDTLSPGKLQALRRDIQFIFQDPYASLDPRQTIGDSIIEPLRVHGLLPGKDAAARVAWLLERVGLLPEHAWRYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDVSIRGQIINLLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVEIGPRRAVFENPQHPYTRKLLAAVPVAEPSRQRPQRVLLSDDLPSNIHLRGEEVAAVSLQCVGPGHYVAQPQSEYAFMRR
Protein: Uncharacterized protein (Q386H0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNKAGVYSLRTDPSLQDYYDACAEGSGDEGNGSGDESDQDSGNYWRSTRRSPLRGKARLRLYQRDSVQKLLRDQGYFASRGPEAEAAASLLSRPLVFAGGSHEANMSCSRQLLPPCTSNDSYVPTTEERLIFDALCALRQSPSTSFAASAGPEGASNLDRPAVWALRRDVMHTASLRGISLSVRSLVDTILTGSNEVARAEWQLQSISTSLSKEDLNTMEDAFTDYSVTTSGDEALMLASHLVLRRLCGIVRSIMRDVSMLALGFLEDEERQQRQTNSSSFTYHRRMEIEKGVEEVLLPLRRCIHIIDCACKLEERAESETGEEDDIDSIDRASGLMDYLIVRMSALQDSSTMDLYRFYMVLLMFFSWPYVQLITSAIFGFVTKIDSDMWRSRVPRIFRLSFSHIRVGEDPRRGQKAAILPTDILSHVFLCVGHARPEGRRWSGRDEGEGGHQRQRQSLSRAERRAAYGSMMSSRSFILHSFVAFARQRALKGWRRKRMADHHAISGCVEQDEWELCRFGRLGSSVEGGATDALPLALCTCHTSASTPVGVGATKWGLCVENYKTHHNIALTDGDRQEKSATGGRSDLWLHPFIPAARWVTVSLLVPIAQVVQRLQERGLTDLLSVAVVPPCVNSSDTADFDDRNETDDGAHMVEEGSSMGEFPSLKSINALQVYSSVSDPSESRASFRDYMSLFIDIALCRDTERIVHKFLYRLFTESHWWYRCGEAEYACSGTASSFISNTFAEAIKEHPLGQFVRLSVAPKLEVVDENDNGSTRVDCQSEMLRTFAAFELVFTLPPDVDLILVPRYLSVEWDESGDVRETYTSYFWKRRQCSEERTGQPAELTDATGQRARDSWSYCFGYLCSLYYAQISLREQRKRLQRQDVDEYNSAAAPGEALFGYRHRAVRVIRGLGSAYFELSFAVDCLLSFNKNVVTVVACEMEKLTRVGSASSCIALCQSLDALLLRLLIVCFPEGASSSLAGASAAKTSITNSVTALLVIALDPASLPVRRVMSCTRSAVEALVAVVRTLPASSAVRKHVKPLLVLLTFNRFYGE
Protein: Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) (P28161)
Organism: Homo sapiens (Human)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers.
Subcellular location: Cytoplasm.
Interaction partners:
- Glutathione S-transferase Mu 1
- Glutathione S-transferase Mu 3
- Glutathione S-transferase Mu 4
- Epoxide hydrolase 1
- Glutathione S-transferase Mu 5
- Cytochrome P450 3A4)
- Cytochrome P450 1B1
- Cytochrome P450 1A1
- Glutathione reductase, mitochondrial
- Cytochrome P450 2E1
Sequence:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
Protein: Protein Shroom1 (Q5SX79)
Organism: Mus musculus (Mouse)
Function: May be involved in the assembly of microtubule arrays during cell elongation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
Sequence:
MEALGTGRDRTSQASATESLDLRRLSTRADSAYSSFSTASGDPETRTPSPGTERLPYLDWDYVRVVWGSQSPTSKDAVLSTTQRPVQAVAGHSDPRSPEVQGSPGPLNRQDTPLLYALAAEAEATAHTAEPPSPPASRDAYRQRLQGAQRRVLRETSFQRKEFRMSLPGRLRPAVPTRLPTAHVRSASSSQELGEEEPARTAVPALAAAGRGRLSSQQRQCCFSEPGKLHRVGWSGGPTGEDLRKDYSTQELQRGMHAKSKGLLETQSLSSTELNSGPADLGNAHRPAGRSQSVSGEVMGPCKGSERTVATVQAVPQRADIRRPLLHTKLSRSLTQKEVTGVCPGEALQTKPAGCGRRISETSVSTPGPSLPEDDVFLREAKTPSPQDSQGLPTSTSYRQYENDLSKKAGQIAVSAERPLHETPGITGTEDCGQAVNGSVDLSRPTSIPETTNDDIPTFDTNGTTDPSAATEKKPLKPPPVDVLRPSDSETPGSPHHTSLTWGQFDSKTTWPSRHFEALVQELARLDPSLSRTLAAQPGPEPPQGLLDGLFPVEEIRSAMRPALEEMGEKAAGASEEGSCGHHLTQDLQTSQEASRSENSTPDPDQSSGQEFPEGNSTQAKKVELARLLQKMLQDLHAEQERLRGTAADWTQRNGALEAAVSQACTPRELERFRRFMTDLERVLGLLLLLGSRLVRVNLALARAGSNSDPDERASLLQRLQLLQRQQEEAKELKEHVARREQTLRQVLERELPAEHLRSYCVLLASKARILSQQRSLDDRIRFLKDQLDTIWSDLSHHPLSPRLTWAPAIRPLNKQPFLATLI
Protein: T-DNA border endonuclease VirD2 (EC 3.1.-.-) (P06668)
Organism: Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
Function: Tumor formation by A.tumefaciens involves the transfer and integration of a defined segment (T-DNA) of Ti plasmid DNA into the plant nuclear genome. The virD operon encodes a site-specific endonuclease that cleaves at a unique site within both 24 bp direct repeats flanking the T-DNA.
Interaction partners:
Sequence:
MPDRAQVIIRIVPGGGTKTLQQIINQLEYLSRKGKLELQRSARHLDIPVPPDQIRELAQSWVTEAGIYDESQSDDDRQQDLTTHIIVSFPAGTDQTAAYEASREWAAEMFGSGYGGGRYNYLTAYHVDRDHPHLHVVVNRRELLGHGWLKISRRHPQLNYDGLRKKMAEISLRHGIVLDATSRAERGIAERPITYAEHRRLERMQAQKIQFEDTDFDETSPEEDRRDLSQSFDPFRSDPSTGEPDRATRHDKQPLEQHARFQESAGSSIKADARIRVSLESERSAQPSASKIPVIGHFGIETSYVAEASVRKRSGIFGTSRPVTDVAMHTVKRQQRSKRRNDEEAGPSGANRKGLKAAQVDSEANVGEQDTRDDSNKAADPVSASIGTEQPEASPKRPRDRHDGELGGRKRARGNRRDDGRGGT
Protein: Homeobox and leucine zipper encoding (A0A669KB72)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAPEQVGIGIGPPTLSKPTQTKGLKVLANGATAASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQGLRHNSVPGRVGPTEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYQKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAIPTPPPSTRSLNERAETPPLPIPPPPPDIQPLERYWAAHQQLRETDIPQLSQASRLSTQQVLDWFDSRLPQPAEVVVCLDEEEEEEEEELPEDDEEEEEEEEEDDDDDDDDVIIQD
Protein: Pentatricopeptide repeat-containing protein At1g25360 (Q9FRI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At5g09450
- bZIP transcription factor 16
- E3 ubiquitin-protein ligase At3g02290
Sequence:
MQPNPDLVRAIANRYAANLRLCLPLRRTSLQLARAVHGNIITFGFQPRAHILNRLIDVYCKSSELNYARQLFDEISEPDKIARTTMVSGYCASGDITLARGVFEKAPVCMRDTVMYNAMITGFSHNNDGYSAINLFCKMKHEGFKPDNFTFASVLAGLALVADDEKQCVQFHAAALKSGAGYITSVSNALVSVYSKCASSPSLLHSARKVFDEILEKDERSWTTMMTGYVKNGYFDLGEELLEGMDDNMKLVAYNAMISGYVNRGFYQEALEMVRRMVSSGIELDEFTYPSVIRACATAGLLQLGKQVHAYVLRREDFSFHFDNSLVSLYYKCGKFDEARAIFEKMPAKDLVSWNALLSGYVSSGHIGEAKLIFKEMKEKNILSWMIMISGLAENGFGEEGLKLFSCMKREGFEPCDYAFSGAIKSCAVLGAYCNGQQYHAQLLKIGFDSSLSAGNALITMYAKCGVVEEARQVFRTMPCLDSVSWNALIAALGQHGHGAEAVDVYEEMLKKGIRPDRITLLTVLTACSHAGLVDQGRKYFDSMETVYRIPPGADHYARLIDLLCRSGKFSDAESVIESLPFKPTAEIWEALLSGCRVHGNMELGIIAADKLFGLIPEHDGTYMLLSNMHAATGQWEEVARVRKLMRDRGVKKEVACSWIEMETQVHTFLVDDTSHPEAEAVYIYLQDLGKEMRRLGYVPDTSFVLHDVESDGHKEDMLTTHSEKIAVAFGLMKLPPGTTIRIFKNLRTCGDCHNFFRFLSWVVQRDIILRDRKRFHHFRNGECSCGNFW
Protein: Amine oxidase (EC 1.4.3.-) (Q8L742)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Polyamine oxidase 1
- Probable polyamine oxidase 5
- Tyrosine decarboxylase 2
- Phenylacetaldehyde synthase
- Polyamine oxidase 2
- Probable polyamine oxidase 4
- Polyamine oxidase 3
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Precursor of CEP12
- Aldehyde dehydrogenase family 7 member B4
Sequence:
MDQKSFFRLIFLIVTAGFIISFTSTNFPHAPTRLLDCTDSSSSPLCASRNFLFNKQQPRPIPKHDPKPNTKNHDHVSDTPNHPLDPLTVSEINKIRSILSSHALFTSGTPHALHTVVLEEPEKNLVRHWEKGNPLPPRKASVIARVGADTHVLTVDISTGRVDSENSPVRVSGYPMMTIEEMNDITVVPFSNADFNRTIISRGVNLTDVICFPISCGWFGNKEENARVIKSQCFMTQGTPNFYMRPIEGLTILIDLDTKQVIEITDTGRAIPIPGSTNTDYRFQKLATTDKTRPLNPISIEQPRGPSFVIEDNHLVKWANWEFHLKPDPRAGVVISRVRVHDPDTHETRDVMYKGFVSELFVPYMDPSDAWYFKTYMDAGEYGFGLQAMPLVPLNDCPRNAAYMDGVFAAADGTPFVRENMVCIFESYAGDIGWRHSESPITGIPIREVRPKVTLVVRMAASVGNYDYIIDYEFQTDGLIKAKVGLSGILMVKGTTYQNKNQVEKDKDGNEEELHGTLLSENVIGVIHDHYVTFYLDLDVDGPDNSFVKVNLKRQETEPGESPRKSYLKAVRNIAKTEKDGQIKLSLYDPSEFHVINSGKTTRVGNPTGYKVVPRTTAASLLDHDDPPQKRGAFTNNQIWVTPYNKSEQWAGGLFTYQSHGDDTLAVWSDRDRDIENKDIVVWYTLGFHHIPCQEDFPIMPTVSSSFDLKPVNFFERNPILSAAPNFEHDLPVCGVQSVSA
Protein: Laminin beta 3 isoform 2 (A0A0S2Z3Z3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRPSSLRKVPASRH
Protein: Cysteine desulfurase IscS (EC 2.8.1.7) (O31269)
Organism: Azotobacter vinelandii
Function: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur from cysteine to produce alanine via an enzyme-bound persulfide intermediate. Functions as a sulfur delivery protein for Fe-S cluster synthesis. Cluster assembly on IscU homodimers proceeds sequentially from 1 2Fe-2S per dimer, to 2 2Fe-2S per dimer and finally 1 4Fe-4S per dimer.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00331}.
Interaction partners:
Sequence:
MKLPIYLDYSATTPVDPRVAQKMCECLTMEGNFGNPASRSHVFGWKAEEAVENARRQVAELVNADPREIVWTSGATESDNLAIKGVAHFNASKGKHIITSKIEHKAVLDTTRQLEREGFEVTYLEPGEDGLITPAMVAAALREDTILVSVMHVNNEIGTVNDIAAIGELTRSRGVLYHVDAAQSTGKVAIDLERMKVDLMSFSAHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERGMRSGTLATHQIVGMGEAFRIAREEMAAESRRIAGLSHRFHEQVSTLEEVYLNGSATARVPHNLNLSFNYVEGESLIMSLRDLAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTFGRFTTEEEVDYAARKVCEAVGKLRELSPLWDMYKDGVDLSKIEWQAH
Protein: DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) (P54098)
Organism: Homo sapiens (Human)
Function: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
Interaction partners:
- DNA polymerase subunit gamma-2
- Twinkle mtDNA helicase
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase delta catalytic subunit
- Single-stranded DNA-binding protein, mitochondrial
- Transcription factor A, mitochondrial
- DNA primase small subunit
- Ribonucleoside-diphosphate reductase subunit M2 B
- ADP/ATP translocase 1
- DNA polymerase zeta catalytic subunit
Sequence:
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP
Protein: Uncharacterized HTH-type transcriptional regulator YieP (P31475)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Probable transport protein HsrA
- Exu regulon transcriptional regulator
- Uxu operon transcriptional regulator
- HTH-type transcriptional regulator McbR
Sequence:
MPLSAQQLAAQKNLSYVLAEKLAQRILKGEYEPGTILPGEIELGEQFGVSRTAVREAVKTLTAKGMVLPRPRIGTRVMPQSNWNFLDQELLTWWMTEENFHQVIDHFLVMRICLEPQACLLAATVGTAEQKAHLNTLMAEMAALKENFRRERWIEVDMAWHEHIYEMSANPFLTSFASLFHSVYHTYFTSITSDTVIKLDLHQAIVDAIIQSDGDAAFKACQALLRSPDK
Protein: Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16) (Q80XF5)
Organism: Mus musculus (Mouse)
Function: Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Subcellular location: Secreted {ECO:0000269|PubMed:12700595}.
Interaction partners:
- Interleukin-22
- Interleukin-22b
- Interleukin-19
- Interleukin-24
- Interleukin-10
- Interferon gamma
- Non-receptor tyrosine-protein kinase TYK2
- Interleukin-6
- Interferon lambda-3
- Interleukin 17D
Sequence:
MMPKHCLLGLLIILLSSATEIQPARVSLTPQKVRFQSRNFHNILHWQAGSSLPSNNSIYFVQYKMYGQSQWEDKVDCWGTTALFCDLTNETLDPYELYYGRVMTACAGRHSAWTRTPRFTPWWETKLDPPVVTITRVNASLRVLLRPPELPNRNQSGKNASMETYYGLVYRVFTINNSLEKEQKAYEGTQRAVEIEGLIPHSSYCVVAEMYQPMFDRRSPRSKERCVHIP