wanglab/gogpt-training-data huggingface dataset:
Protein: Pre-mRNA-splicing factor 18 (PRP18 homolog) (Potassium channel regulatory factor) (Q9JKB8)
Organism: Rattus norvegicus (Rat)
Function: Participates in the second step of pre-mRNA splicing (By similarity). Down-regulates the expression of potassium channel subunits.
Subcellular location: Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor SLU7
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Cell division cycle 5-like protein
- Protein BUD31 homolog
- Pre-mRNA-processing-splicing factor 8
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Cell division cycle 40.
- Pre-mRNA-splicing factor ISY1 homolog
- CWC25 spliceosome-associated protein homolog
- 116 kDa U5 small nuclear ribonucleoprotein component
Sequence:
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKVQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPMRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNSREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL
Protein: E3 ubiquitin-protein ligase SPL11 (EC 2.3.2.27) (Cell death-related protein SPL11) (Protein spotted leaf 11) (RING-type E3 ubiquitin transferase SPL11) (Q0IMG9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: E3 ubiquitin-protein ligase that negatively regulates programmed cell death and disease resistance. Participates in flowering time control by mediating ubiquitination and subsequent proteasomal degradation of SPIN1.
Subcellular location: Nucleus {ECO:0000269|PubMed:18586868}. Cytoplasm {ECO:0000269|PubMed:18586868}.
Interaction partners:
Sequence:
MAGDRAEEEEGEAPPPEARAAAAVERVAAAVEAVAAGAGAGAGEYRNAYRRQLLALSRRIRLLGPFVEELRERRRGEGEGEEEERALAPLADALEAALALLRLGREGSRISLVLERDSVMKKFQGVILQLEQALCDIPYNELDISDEVREQVELVHAQLKRAKERIDMPDDEFYNDLLSVYDKNYDPSAELAILGRLSEKLHLMTITDLTQESLALHEMVASGGGQDPGEHIERMSMLLKKIKDFVQTQNPDMGPPMASRVLDSNGDSRPITIPDEFRCPISLELMKDPVIVSTGQTYERACIEKWIASGHHTCPTTQQKMSTSALTPNYVLRSLISQWCETNGMEPPKRSTQPNKPTPACSSSERANIDALLSKLCSPDTEEQRSAAAELRLLAKRNANNRICIAEAGAIPLLLSLLSSSDLRTQEHAVTALLNLSIHEDNKASIISSGAVPSIVHVLKNGSMEARENAAATLFSLSVIDEYKVTIGGMGAIPALVVLLGEGSQRGKKDAAAALFNLCIYQGNKGRAIRAGLVPLIMGLVTNPTGALMDEAMAILSILSSHPEGKAAIGAAEPVPVLVEMIGSGTPRNRENAAAVMLHLCSGEHHLVHLARAQECGIMVPLRELALNGTDRGKRKAVQLLERMSRFLVQQQEEQESQSQASAQVPPQATPEQVPENDIPEQLDSPASQYPMVV
Protein: All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (ADH-C2) (Alcohol dehydrogenase 7) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase) (Q64437)
Organism: Mus musculus (Mouse)
Function: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.
Subcellular location: Cytoplasm.
Interaction partners:
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Retinal dehydrogenase 2
- Cytochrome P450 2E1
- Aldehyde dehydrogenase 1A1
- Retinaldehyde dehydrogenase 3
- Aldehyde dehydrogenase family 3 member B2
- Lecithin retinol acyltransferase
- Aldehyde dehydrogenase, cytosolic 1
- Cytochrome P450 26A1
- Aldehyde dehydrogenase family 3 member B1
Sequence:
MGTAGKVIKCKAAVLWGVNQPFSIEEIEVAPPKAKEVRVKILATGICRTDDHIIKGSMVSKFPVIVGHEAVGVVESVGEGVTTVRPGDKVIPLFLPQCRECNACLNPEGNLCIRSDLTGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKVDGAAPPEKACLIGCGFSTGYGAAVKTAKVTPGSTCVVFGLGGVGLSVIMGCKAAGASRIIGIDINKDKFQKALAVGATECISPKDSTKPISEVLSDMTGNTIQYTFEVIGRLETMVDALSSCHMNYGTSVVVGAPPSAKMLTYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLDQLITHTLPFNNINEGFELLYSGKSIRTVLTF
Protein: Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein) (Q9Y6H5)
Organism: Homo sapiens (Human)
Function: Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:15064394, ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19762560}. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Alpha-synuclein
- E3 ubiquitin-protein ligase SIAH1
- E3 ubiquitin-protein ligase SIAH2
- Prosaposin receptor GPR37
- Serine/threonine-protein kinase PINK1, mitochondrial
- Sodium-dependent dopamine transporter
- Beta-synuclein
- E3 ubiquitin-protein ligase RNF19A
- NEDD8 ultimate buster 1
Sequence:
MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSASKGKNKAA
Protein: Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) (Q9NQS3)
Organism: Homo sapiens (Human)
Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26038560}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JLB9}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9JLB9}. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of supporting cells. {ECO:0000250|UniProtKB:Q9JLB9}.
Interaction partners:
- T-cell immunoreceptor with Ig and ITIM domains
- Afadin
- Nectin-2
- Nectin-1
- Poliovirus receptor
- Cell adhesion molecule 1
- Partitioning defective 3 homolog
- Cell adhesion molecule 3
- Nectin-4
- Protein PALS2
Sequence:
MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
Protein: Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.104) (EC 1.1.1.30) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (4-oxo-L-proline reductase) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) (D6R9U8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAF
Protein: phosphatidylinositol N-acetylglucosaminyltransferase (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Q585S5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PhosphatidylinositolN-acetylglucosaminyltransferase subunit c, putative
- GPI-GlcNAc transferase complex PIG-H component conserved domain-containing protein
- PIG-P domain-containing protein
- Dolichol phosphate-mannose biosynthesis regulatory protein
- N-acetylglucosaminyltransferase, putative
- N-acetylglucosaminylphosphatidylinositol deacetylase
- Cytoplasmic tRNA 2-thiolation protein 2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
- Probable methyltransferase BMT2 homolog
Sequence:
MRRHRVAVVSDFFYPGFGGVEVHIYSLGQCLMRRGHKVIVITRAYGDTCGVRYLTNGMKVYYLPLMAVKLPAGSVTLPTMYLTFATMRSIFIRERITVVHGHQNTSNLCHEALFHAGTLGLKTCFTDHSLFGFADVSSIHINKVCEWSLRNVDQVICVSNTSRENTVLRAKIDPQRVSVIPNATDCSFFTPPDDMKYKSWASKVENEGLTIVVIGRLVYRKGSDLFVDVIPEICKRHPNIRWIVGGDGPRRSQFQQMIERHDLMDRVKMLGSLPHSGVRNVLIQGQIFLNCSLTEAFCIALIEAASCGLLCVSTRVGGVPEVLPPNMLLLAEPDPSSIITTLEEAIASVPYISPWELHDNVRRFYRWDWVAERTERVYDKIMCTKSPSLYERLMNYASVGCVYGVICWLLCIGDWLMLTFLEFWFPSELIDIAPDFPLELYSRNREKLQVVGSPS
Protein: Trypsin-resistant surface T6 protein (T6 antigen) (P18481)
Organism: Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Subcellular location: Secreted, cell wall {ECO:0000255|PROSITE-ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-ProRule:PRU00477}.
Interaction partners:
Sequence:
MLACLAILAVVGLGMTRVSALSKDDTAQLKITNIEGGPTVTLYKIGEGVYNTNGDSFINFKYAEGVSLTETGPTSQEITTIANGINTGKIKPFSTENVSISNGTATYNARGASVYIALLTGATDGRTYNPILLAASYNGEGNLVTKNIDSKSNYLYGQTSVAKSSLPSITKKVTGTIDDVNKKTTSLGSVLSYSLTFELPSYTKEAVNKTVYVSDNMSEGLTFNFNSLTVEWKGKMANITEDGSVMVENTKIGIAKEVNNGFNLSFIYDSLESISPNISYKAVVNNKAIVGEEGNPNKAEFFYSNNPTKGNTYDNLDKKPDKGNGITSKEDSKIVYTYQIAFRKVDSVSKTPLIGAIFGVYDTSNKLIDIVTTNKNGYAISTQVSSGKYKIKELKAPKGYSLNTETYEITANWVTATVKTSANSKSTTYTSDKNKATDNSEQVGWLKNGIFYSIDSRPTGNDVKEAYIESTKALTDGTTFSKSNEGSGTVLLETDIPNTKLGELPSTGSIGTYLFKAIGSAAMIGAIGIYIVKRRKA
Protein: Ragulator complex protein LAMTOR3 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (Q9VJD2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.
Interaction partners:
- Ragulator complex protein LAMTOR1
- Ragulator complex protein LAMTOR4 homolog
- Ragulator complex protein LAMTOR2 homolog
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
- GH16429p
- GH04846p
- Raptor, isoform B
- WD repeat domain-containing protein 83
- Folliculin
- Serine/threonine-protein kinase mTor
Sequence:
MSDDIKKYLDGLLQKVSGLYVIQITDRDGVPLLRVSQEKNVDFALMPSFIPTFTTACDQASKLGLGRNKTIISMYSNYQVVQMNKLPLILTFVGAENCNTGHILALEHQVDGYLEDIKQAVTEA
Protein: Glutamate dehydrogenase (Q8JHX9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MYRYFGELLSRGAGSALASGCVDSALPASASLMRVRQYSEQPDDPNFFRMVEGFFDRGAAIVEDKLVEDLKSRETPEQKTKRVKGILRIIKPCNHVLSVSFPIKRDNGEWEVVEGYRAQHSQHRTPCKGGIRYSEEVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINVKNYSDNELEKITRRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYANTIAHTDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSMLGLNPGFQDKTFIIQGFGNVGLHSMRYLHRYGAKCVGIAEYDGSIYNPEGIDPKQLEDYKLQHGTIVGFPGAQPYEGSLLEAQCHILIPAASEKQLTRNNAHRIKAKIIAEGANGPTTPDADKIFLENKVMVIPDMYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKQGGPIPIVPTXDFQARVAGASEKDIVHSGLAYTMERSARQIMRTASKYNLGLDLRTAAYVNAIEKVFKVYNEAGITVT
Protein: Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) (P32926)
Organism: Homo sapiens (Human)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30949721, ECO:0000269|PubMed:31835537}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000250|UniProtKB:O35902}. Cytoplasm {ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:31835537}. Cell junction, tight junction {ECO:0000269|PubMed:22796473}. Cell junction {ECO:0000269|PubMed:18343367}.
Interaction partners:
- Plakophilin-3
- Plakophilin-1
- Desmoplakin
- Desmocollin-3
- Periplakin
- Desmocollin-2
- Envoplakin
- Plakophilin-2
- Dystonin
- Desmoglein-1
Sequence:
MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI
Protein: 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) (F4I2W6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MANSASLLYDQLKVAEPFFLLAGPNVIESEEHVLRMAKSIKDISTKYVLGLPLVFKSSFDKANRTSSKSFRGPGMAEGLKILEKVKVAFDLPIVTDVHESSQCEAVGKVADIIQIPAFLCRQTDLLVAAAQSGKIINIKKGQFCGHSVMRNSAEKVRLAGNPNVMVCERGTMFGYNDLIVDPRNLEWMREADCPVVADITHSLQQPAGKKLDGGGVASGGLRELIPCIARTAVAVGVDGIFMEVHDDPLNAPVDGPTQWPLRHLEELLEELIAIASVTKGKQQFQIDLTPYRD
Protein: Eukaryotic translation initiation factor 5A-3 (AtELF5A-3) (eIF-5A-3) (Q9C505)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The precise role of eIF-5A in protein biosynthesis is not known but it may function as a bimodular protein capable of binding to both RNA and proteins. Involved in supporting growth and plays a regulatory role in the response to sub-lethal osmotic and nutrient stress.
Interaction partners:
- Deoxyhypusine synthase
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS6z
- Deoxyhypusine hydroxylase
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein bL28c
- Small ribosomal subunit protein eS1y
- Large ribosomal subunit protein bL31c
Sequence:
MSDDEHHFESSDAGASKTYPQQAGNIRKGGHIVIKGRPCKVVEVSTSKTGKHGHAKCHFVAIDIFTSKKLEDIVPSSHNCDVPHVNRVDYQLIDISEDGFVSLLTDNGSTKDDLKLPTDEALLTQLKNGFEEGKDIVVSVMSAMGEEQMCALKEVGPK
Protein: Krueppel-like factor 4 (Kruppel-like transcription factor 4a) (A9X6Q5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRQPPTEFDSMALSGTILPSISTFASGTDVKHKAVLGPGAAGSRWKEEMSHLKRPCMSTGATCADQDVPPVMAKIEPEELELLDYDFILSNSLLQQQQQQQASTSRTIPASSPTHYTFPMPSPQGQEGSMLYTIPDISDVSPSGGFVAELMRPELDPAYLQPTSLHGKFVVKTTMDMSDYNQGVSISKDASAVPFACPRIKQECPSTCTASRPMDLHLRGSSAQSGVHQGSMLDPHAFSSGRGARSSLSPDEHPQAPGLGSGYHPNTAYSGFPQAPAQSLQYQELISPAEGLPEESKPKRGRRSWPRKRIATHTCDYAGCGKTYTKSSHLKAHHRTHTGEKPYHCDWEGCGWKFARSDELTRHYRKHTGIRPFQCLKCDRAFSRSDHLALHMKRHL
Protein: Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208) (Q9UQV4)
Organism: Homo sapiens (Human)
Function: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.
Subcellular location: Cell surface {ECO:0000269|PubMed:27329040}. Lysosome membrane {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21810281}; Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269|PubMed:9768752}.
Interaction partners:
- Macrosialin
- Lysosome-associated membrane glycoprotein 1
- C-type lectin domain family 4 member K
- CD83 antigen
Sequence:
MPRQLSAAAALFASLAVILHDGSQMRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGNVDECSSDYTIVLPVIGAIVVGLCLMGMGVYKIRLRCQSSGYQRI
Protein: Peptidoglycan-recognition protein SD (Q9VS97)
Organism: Drosophila melanogaster (Fruit fly)
Function: Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Gram-negative bacteria-binding protein 1
- Diptericin B
- Metchnikowin
- Attacin-C
- Attacin-A
- Peptidoglycan-recognition protein SB1
- Cecropin-C
- Drosocin antimicrobial peptides
- Protein immune deficiency
- Cecropin-B
Sequence:
MTWIGLLIVGLTAIAVQGEVPIVTRAEWNAKPPNGAIDSMETPLPRAVIAHTAGGACADDVTCSQHMQNLQNFQMSKQKFSDIGYHYLIGGNGKVYEGRSPSQRGAFAGPNNDGSLGIAFIGNFEERAPNKEALDAAKELLEQAVKQAQLVEGYKLLGHRQVSATKSPGEALYALIQQWPNWSEEM
Protein: E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase HRD1) (Septin-interacting protein 3) (Synoviolin) (Q95SP2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Derlin
- Endoplasmic reticulum lectin 1
- Derlin-1
- HMG-coA reductase degradation 3, isoform A
- Ubiquitin-conjugating enzyme E2 G2
- Transitional endoplasmic reticulum ATPase TER94
- Argus, isoform A
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- RING-type E3 ubiquitin transferase
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MQLLLSSVCMALTSAVIGFAYYQKQQFYPAVVYITKSNASMGVIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETCLAFTVFRDDFNPRFVALFTVLLFLKSFHWLAEERVDFMERSPVLGWLFHIRVGSLLTVLGILDYVLLIHAYNSTLVRGPTVQLVFGFEYAILLTVIASTAIKYVLHAAEMRTDTPWENKAVFLLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTIRNFRKALNDVIMSRRAIRNMNTLYPDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDEAVAAAAGNPIPAAAGVQPAGGVPPPAPTAVVDGNQARADVNVAGGQALPPNFADLFGDASGLPNGLPNLAGLQIPPPPVMPMISPFMIPPHFGYLTPLPPPPIPQDLTNFTDEELRAMEGLQRDHIVQRLKLLQNINLMLDSAGIMMSQYQSLSARLQLTAVTPATAVNGSADSSVYDMPSTSATAMAQLETHQVTPTAAASSASPTMPAEKVTIEDLGADADEDDIPSTATEAVSIPNSDADFEENSSELGELRKRRLKFLEERNKSAATNERTTAE
Protein: Oxidation resistance protein 1 (Q08952)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in protection from oxidative damage.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15060142}.
Interaction partners:
Sequence:
MFGVKDAIFKIKRSIAGTDSSDSTAYTTASESSPQLKDSHNPFRNKTTSERTIVEEGSLPPVRLNGYLPSTKNKLLTPEMCDEIRTLMPTRIQLYTEWNLLYSLEQHGSSLHSLYSNVAPDSKEFRRVGYVLVIKDRKNGIFGAYSNEAFHPNEHRQYTGNGECFLWKLDKVPDVNISEKEESEQEGKEGKEEGDKEERWRFSGYPYTGVNEFAIYCTSEFLSMGAGDGHYGLLCDDGLLHGVSNPCQTYGNEVLSKEGKKFSIVALEVWRVG
Protein: Ly6/PLAUR domain-containing protein 1 (Ly-6/neurotoxin-like protein 2) (Lynx2) (Q8BLC3)
Organism: Mus musculus (Mouse)
Function: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Neuronal acetylcholine receptor subunit alpha-7
- Ly-6/neurotoxin-like protein 1
Sequence:
MWVLGIAATFCGLFWLPGLALQIQCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPKKRGSSASAIRPGLLTTLLFFHLALCLAHC
Protein: G-protein coupled receptor 4 (G-protein coupled receptor 6C.l) (GPR6C.l) (P46093)
Organism: Homo sapiens (Human)
Function: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17462861, ECO:0000269|PubMed:20211729}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 4
Sequence:
MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ