wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial calcium uniporter regulator 1 (MCU regulator 1) (Coiled-coil domain-containing protein 90A, mitochondrial) (Q96AQ8)
Organism: Homo sapiens (Human)
Function: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23178883}; Multi-pass membrane protein {ECO:0000269|PubMed:23178883}.
Interaction partners:
- Calcium uptake protein 2, mitochondrial
- Calcium uniporter regulatory subunit MCUb, mitochondrial
- Calcium uptake protein 1, mitochondrial
- Essential MCU regulator, mitochondrial
- Calcium uptake protein 3, mitochondrial
- Mitochondrial adenyl nucleotide antiporter SLC25A23
- Calcium uniporter protein, mitochondrial
- Mitochondrial proton/calcium exchanger protein/H
- Mitochondrial sodium/calcium exchanger protein
Sequence:
MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAARGGVSRASPLLLLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAAGALPQYHGPAPALVSCRRELSLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKIETEVAGLKTMLESHKLDNIKYLAGSIFTCLTVALGFYRLWI
Protein: Net, isoform B (Net, isoform C) (Q9VPI8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI24210p1
Sequence:
MANTNTEKLYMQLSASELSAIIMKDSPNSNDRDAGFCSASSESEGGDDLVVEHARSGSPDIRPKGTDSADSKPIALVRNKRKSSEPFKVVGLTTPNSKSMPGPPSSASMNATGPLKKRIRYTSSADSAVVLTPPAIDSPPPNSCIPSTLRLQHEIMPNPAHIYVRHPGVTTLHRSLAAHPEQLEPLALVTTKKQCVDQAGPKIEAFSALLIGKQPSAKKTLKERTQKESTSSSFLEASLSDEDLNKTGLAPISRPHQHQRNYKNMTRERRIEANARERTRVHTISAAYETLRQAVPAYASTQKLSKLSVLRVACSYILTLSRMAGEDYSADQSVPSIATCLEAVTSTIQTEGKVKRKKDE
Protein: Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2) (O14647)
Organism: Homo sapiens (Human)
Function: DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Binds to myogenic gene promoters. {ECO:0000250}.
Interaction partners:
- RNA polymerase-associated protein LEO1
Sequence:
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKKERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRPVPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSRLGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNSKTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEPQEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELIHNSCVSAMQEYEEQLKENASEGKGPGKRRGPTIKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYGNWELIKTDPELKLTDKILPVETDKKPQGKQLQTRADYLLKLLRKGLEKKGAVTGGEEAKLKKRKPRVKKENKVPRLKEEHGIELSSPRHSDNPSEEGEVKDDGLEKSPMKKKQKKKENKENKEKQMSSRKDKEGDKERKKSKDKKEKPKSGDAKSSSKSKRSQGPVHITAGSEPVPIGEDEDDDLDQETFSICKERMRPVKKALKQLDKPDKGLNVQEQLEHTRNCLLKIGDRIAECLKAYSDQEHIKLWRRNLWIFVSKFTEFDARKLHKLYKMAHKKRSQEEEEQKKKDDVTGGKKPFRPEASGSSRDSLISQSHTSHNLHPQKPHLPASHGPQMHGHPRDNYNHPNKRHFSNADRGDWQRERKFNYGGGNNNPPWGSDRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYDQYSSDRDHRGHRDYYDRHHHDSKRRRSDEFRPQNYHQQDFRRMSDHRPAMGYHGQGPSDHYRSFHTDKLGEYKQPLPPLHPAVSDPRSPPSQKSPHDSKSPLDHRSPLERSLEQKNNPDYNWNVRKT
Protein: Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (Transcription initiation factor IIA small chain) (O74948)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with tbp mediates transcriptional activity (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Transcription initiation factor IIA large subunit
- TATA-box-binding protein
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIF subunit alpha
- General transcription and DNA repair factor IIH subunit ssl1
- Transcription initiation factor IIB
- Transcription initiation factor IIF subunit beta
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerase II subunit RPB11
Sequence:
MSQYYELYRRSSIGISLTDALDDLISQGKISPQLAMKVLFNFDKSMTEALAEKVRSRLTFKGHLDTYRFCDEVWTFIIKNPSFRFDNETVTSNKIRIVACATRDSSANR
Protein: Estrogen receptor beta (Nuclear receptor subfamily 3 group A member 2) (A0A348FV93)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002527}.
Interaction partners:
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARSCVYK
Protein: Complex 1 LYR protein domain-containing protein (Q388C0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
- SET domain-containing protein
- NADH dehydrogenase 1 beta subcomplex subunit 7
- Flavoprotein monooxygenase, putative
- Sulfotransferase
- Uncharacterized protein
- Uncharacterized protein
- Complex 1 LYR protein domain-containing protein
- FAD-binding domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLRRACLAGRVSAIATPGFATCKILSSVSSSGNDKKNTKAGLLSGSGSEGHHTGPIPGATGKDNRQGIYSTRGSPSYFEKRYPRKEGELVSKQVVDPNEPRDRSDNLKAPEFDTSLGKFEQAPYFTGGPGAMRYNNYVREPVDKEGVDYRDVVPLPPFEDHHPDFSYASATGKREGDITLLANTVVNWEIKAAMMSLYRSCLKGLPMVKHYYWLLTPLPEMKSKIRERFLQNQHTKDPDAIRHLLHNGWMEYQEVILFRRTRASVAKFFEWESQDELVRGYTREEGKMQEERAFWNGEEQRREGPYDGHWSWLGKESEKEFAKIAGRIPISWSTSKGYFEKGQADGTNYWEKNLDYEGWYIKNVDPDRQNARREMQGWIESGYNQPKHYASKNRRGYRRLVKDIETMMETSMEDLYTKNREQLFQYLIRETHPESNRINAERVLARQDDDFYSTRFDEYEKYLKQAMREMPNPRLWKTDAFYFRLRYLLAPLEYNWAKVPIGISQEKLYNEWISDNANYAILNSATFSNIKNNKLKNPMARTWADFYNDYDPDVPETRRLPWYHPDFDYDRRHKWDERCMRMKRWVQGGTIDGKLPYFDSIIAEWEQYVNRPERFRASDSAERRYAAPRMVQLYRSLNRLMDVALVNQMRAVVESSLLNTQVELSRASVTDIQRMLISVDFTDFRFVVPTIIYPDGVQQPVVGLDGNVVVSQI
Protein: T. brucei spp.-specific protein (Q381Z5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGDCDRLKCLIGELDGYAQVLSERVQQKEAELGLLLVQVATMGGAALRADGGQTSPVVLPECDLRIAPPRHAHDPVTSTVQRKLLSPLPTVRICDPTTSLGPVSVTEPIRVCSMSSPVGTLSPIERACSSGYSSSEESTITIIRALDDTVKPRTVRHVRFAPSRLSSSPHCARVSPPTEGADRGGVCTRGSFFPTRFTVATLERQYTESGASTQQCAAASESECHRGGEIAAPSEVETGGGPNDIDTVHYVRRRVTSSRRPSTRLSASNTSVELLISNNSAATCSSPGAKGRGRHAQCNIPRKRWRKSESRGVSAGTSASVSAARPRTAVVAEEEKEEGIDAGITLACGPTLFFE
Protein: CCAAT/enhancer binding protein zeta (A0A8I6ASJ7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSADQEPLEFLAKNPWRPKEVTEDPDEEDEEDSDEAKNGFSLEEVLRLGGTKQDYLMLATLDENEEVVDGGKKGTIDDLQQGELEAFIQNLNLAKYSKSLIEEDEPEKKENTSKKEAKLPKVENKKQKAAEGKKKNKSVPEQHPESSTVFKAKRDKQPDAFEFLERQALLLKPGGKWYDMEYSGEFSLEPQPWDVVSKYKALAEKLYEQEVGLFKNKTSNQKGGSSTWMKAIVSSGTLADRMAAMILLIQDDAVHTLQFVETLLSLVRKKGSKQQCLMALDTFKELLITDLLPDSRKLRLFSQRPLHKLEELSSGNKDSRDRRLILWYYEHQLKHLVAEFVQVLETLSHDSLVTTKTRALVAAHELLCDKPEEEKALLVQVINKLGDPQNRIATKASHLLEVLLRKHPNMKGVVCGELERLLFRSNISPKAQYYAICFLNQMVLSHEESELANKLITLYFCFFRTCIKKKDIESKMLSAILTGVNRAYPYSQIGDDRVREQVDTLFKVLHVVNFNTSVQALMLLFQVMNSQQTISDRYYTALYKKMLDPGLTTCSKQAMFLNLIYKSLKADIMLRRVKAFVKRLLQVTCTQMPPFICGALYLVSEILKAKPDLRSQLDDHPESDEENFVDVGDDSDDEKFTDADRETATDAVEEVEAKEAEPESSTETEKPKAASWVHFDNLKGGKQIKTYDPFGRNPLFCGAEHTNLWELRKLSQHFHPSVALFAKTILEGNHIQYSGDPLQDFTLMRFLDRFVYRNPKLHKGKENTDSVVMQPKRKHFMKNVRDLAVNSKEFLAKEESQIPVDEVFFYRYYKKVAVTKDKQKRNADEDSIEDVDDEEFENMIDTFEDDNCFTPGKDDMDFASNMKKIKGAKDDLEDSESSDDELGDLDDDEVSLGSMNDEDFEIDEDGGTFMDVSDDESDHVPEFGEASPKASTKKSKRKSEDDFDFAGSFQGKKILPRLPSFLFFKFGHLLDENMGSKFDTTGMNAMANKDNASFKQLKWEAERDDWLHNRDVKSIIKKKKNFRKKKAPQKPKRQRK
Protein: UDP-rhamnose/UDP-galactose transporter 4 (UDP-Rha/UDP-Gal transporter 4) (Bi-functional UDP-rhamnose/UDP-galactose transporter) (Nucleotide sugar transporter-KT 1) (AtNST-KT1) (Q8RWW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nucleotide-sugar transporter that transports UDP-rhamnose or UDP-galactose and UMP in a strict counter-exchange mode.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16831428, ECO:0000269|PubMed:25053812}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein
- DNAJ heat shock N-terminal domain-containing protein
- U6 small nuclear RNA
- Probable pectinesterase/pectinesterase inhibitor 58
- ER membrane protein complex subunit 3
- Probable pectinesterase 53
Sequence:
MFKKMSATTSKTDQKAALDIASWLFNVVTSVGIILVNKALMATYGFSFATTLTGLHFGTTTLLTTFLTWLGYIQPSQLPWPDLLKFVLFANFSIVGMNVSLMWNSVGFYQIAKLSMIPVSCLLEVMLDNVRYSRDTKLSILLVLAGVAVCTVTDVSVNLNGFLAAAIAVWSTALQQYYVHYLQRKYSLGSFNLLAHTAPVQAASLLLVGPFLDYWLTNQRVDAYNFSFVSLFFLILSCSIAVGTNLSQFICIGRFTAVSFQVLGHMKTILVLVLGFTFFGKEGLNLQVVLGMLIAILGMIWYGNASSKPGGKERRSLSIPITKSQKLSETNESDEKV
Protein: Nucleoporin 43kD (Q9VE85)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear pore complex protein Nup160 homolog
- Nucleoporin Nup37
- Protein SEC13 homolog
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup75
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup107
- Nucleoporin seh1
- Nuclear pore complex protein Nup205
- Nuclear pore complex protein Nup154
Sequence:
MSIANVSTHYISEKVSQVRWLPEELQQSERFVTGSWDMDQNFVRLWRLQSNQYVTATDSEVDQIPRCMDKVRMEDDVTAMEFVDKDTLAVSCADGHLSVFNVHRAVEEDQMQRTSRSGRLHCFQRSQEPAPCTDLSVYGTDIATAGEDGCVSIVSVENVRQVKRQIEADSMALFSICYISQQELVTANRMGVIRMLDARVATEAQPKTTFMVASQDDKSNFVSSLAKHPMQQHILLCGSEEGSITVWDMRNLSYPASYLSAHKSPINEIGFHQKDPSKLFTAAEGGEVWMWSENKVLGCDYNKDGHSPWLSGDRVRSLVDVEGVLSNVRKSINSFDVHGSRLVCGGDTEAVYLVDNIV
Protein: Uridine kinase (EC 2.7.1.48) (Uridine monophosphokinase) (O74427)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uridylate kinase
- Putative cytidine deaminase
- Putative uracil phosphoribosyltransferase urg2
- Uracil phosphoribosyltransferase 1
- Orotidine 5'-phosphate decarboxylase
- Uracil phosphoribosyltransferase 2
- Golgi apyrase
- Uncharacterized protein C1683.06c
- Protein urg3
- Uncharacterized transcriptional regulatory protein C1399.05c
Sequence:
MPEAFERYSSNPTYEPPWRKVRFIGIAGPSGSGKTSVAQLIVKALNLPHVVILSLDSFYKSLNAEQKKRAFNNDYDFDSPEAIDWDLLFVKLLELKQGRKVDIPIYSFNEHNRLPETNTLFGASIIILEGIFALYDEKIRSLLDVSVFLDTDSDVCLSRRLNRDINYRGRDIVGVLEQYNKFVKPSYENFVRRQLSYTDLIVPRGRDNKLAIDMVINFIRRTLSIQSETHVKNIDSLQQIVPTIPHLPLNLVQLKITPEISAIRTILINKNTHPDDLQFFLSRIGTMLMNLAGDSLAYEKKTITLHNGNQWEGLQMAKELCGVSVLRSGGTLETALCRQFPTVCLGKILVQINKVTQEPTLHYHKLPRGIATMNVVLMASHLTTHADVLMATQILVDFGVPEENIIIVVYVCYSESIKALAYIFPKVTIVTAFLESVAEPVVGRLDIEKVYYGC
Protein: Ubiquitin-related modifier 1 (Q9BTM9)
Organism: Homo sapiens (Human)
Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular location: Cytoplasm.
Interaction partners:
- Cytoplasmic tRNA 2-thiolation protein 1
- Adenylyltransferase and sulfurtransferase MOCS3
- Cytoplasmic tRNA 2-thiolation protein 2
- Cysteine desulfurase
- 3-mercaptopyruvate sulfurtransferase
- Elongator complex protein 3
- Ubiquitin-fold modifier 1
- Multifunctional methyltransferase subunit TRM112-like protein
- Elongator complex protein 4
- Gamma-aminobutyric acid receptor-associated protein-like 2
Sequence:
MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPWDIRNLLIWIKKNLLKERPELFIQGDSVRPGILVLINDADWELLGELDYQLQDQDSVLFISTLHGG
Protein: Octanoyltransferase LIP2p, chloroplastic (EC 2.3.1.181) (Lipoate-protein ligase 2p) (Lipoyl-[acyl-carrier-protein]-protein-N-lipoyltransferase 2p) (Plastidial lipoyltransferase 2) (Q948J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). Together with LIP1P is essential for de novo plastidial protein lipoylation during seed development. Acts redundantly with LIP2P2.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11602263, ECO:0000269|PubMed:23581459}.
Interaction partners:
- Lipoyl synthase, mitochondrial
- Lipoyl synthase, chloroplastic
- Ethylene-responsive transcription factor ERF015
- Pentatricopeptide repeat-containing protein At1g02060
- GTPase ERA-like, chloroplastic
- Transmembrane protein
- Octanoyltransferase LIP2, mitochondrial
- Octanoyltransferase LIP2p2, chloroplastic
- Nucleolar histone methyltransferase-related protein
- Protein kinase superfamily protein
Sequence:
MELLNGVETLVSGIHHHHRTNAKRNRLVRSVKILNSGNHEIPRKCLCFDLYDKLVPYKKAWSWQKSIVEEKKTLIDRNQDCADTVILLQHSPVYTMGTASTEDYLNFDIKDAPFNVYRTERGGEVTYHGPGQLVMYPIINLRNHEMDLHWYLRMLEEIVIRVLSSTFSIKASRLDGLTGVWVGNQKVAAIGIRVSKWITYHGLALNVTTDLTPFNWIVPCGIRDRKVGNIKGLLEDGEHGMVDDLRLIDIVHESLLKEFSEAFQLQIEKQTVSDPNIL
Protein: OTU domain-containing protein 2 (P38747)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Ubiquitin thioesterase OTU1
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin carboxyl-terminal hydrolase 2
- Ubiquitin carboxyl-terminal hydrolase 9
- Ubiquitin carboxyl-terminal hydrolase 3
- Adaptin medium chain homolog APM2
- Ubiquitin carboxyl-terminal hydrolase 15
- Ubiquitin carboxyl-terminal hydrolase 4
- Ubiquitin carboxyl-terminal hydrolase 6
- Ubiquitin carboxyl-terminal hydrolase YUH1
Sequence:
MTGMESGENLENMEDILARHRKENKDLQNKITGMKKQATKSKRKEVNSKCLDLQDKLKTKQENEIRDWKIANNEVFDAEQEDEVTPEKLLEQLSISRDEKEQQNVPVQQQQQGQTKKRRNRQKERLAKRDAAIAKMKEEAALEASKQPDLKKMEQESIDQLCELKKLKQFDIQPDGHCLFASILDQLKLRHDPKKLDQDMDVMKLRWLSCNYVQEHRDDFIPYLFDEETMKMKDIDEYTKEMEHTAQWGGEIEILALSHVFDCPISILMSGRPIQVYNECGKNPELKLVYYKHSYALGEHYNSLHDS
Protein: Malate dehydrogenase (EC 1.1.1.37) (Q4Q3J2)
Organism: Leishmania major
Interaction partners:
- Probable citrate synthase, mitochondrial
- Citrate synthase
- phosphoenolpyruvate carboxykinase
- phosphoenolpyruvate carboxykinase
- Fumarate hydratase 2
- Fumarate hydratase 1, mitochondrial
- Aspartate aminotransferase
- Putative malic enzyme
- Transaminase A
- Adenylosuccinate lyase
Sequence:
MRSSATRLFRVAVLGAAGGIGQPLSLLLKCSPLVTSLSLYDIRGGPGVAADLSHIPSPAEVIGFSSGELEKAVKGADLVLVVAGIPRKPGMTRDDLLHTNASIVRDLAIAVGTHAPKAIVGIITNPVNSTVPVAAEALKKVGVYDPARLFGVTTLDVVRARTFVAEALGASPYDVDVPVIGGHSGETIVPLLSGFPSLSEEQVRQLTHRIQFGGDEVVKAKDGAGSATLSMAYAASEWSISMLKALRGDRGIVEYALVESDMQQPHSRFFGCAVELGTHGVERVLPMPKLNAYEQQLLDACVPALSAEFRKGVDLAVKLHLSQDN
Protein: Copper metallothionein 1-1 (Cu-MT) (Cu-metallothionein) (Copper chelatin) (Copper thionein) (P0CX80)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins.
Interaction partners:
- Transcriptional activator protein CUP2
- Superoxide dismutase
- Orotidine 5'-phosphate decarboxylase
- Galactokinase
- 3-isopropylmalate dehydrogenase
- Phosphoglycerate kinase
Sequence:
MFSELINFQNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGNKSEETKKSCCSGK
Protein: Viral interleukin-10 homolog (cmvIL-10) (vIL-10) (P17150)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MLSVMVSSSLVLIVFFLGASEEAKPATTTIKNTKPQCRPEDYATRLQDLRVTFHRVKPTLQREDDYSVWLDGTVVKGCWGCSVMDWLLRRYLEIVFPAGDHVYPGLKTELHSMRSTLESIYKDMRQCPLLGCGDKSVISRLSQEAERKSDNGTRKGLSELDTLFSRLEEYLHSRK
Protein: Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) (P04350)
Organism: Homo sapiens (Human)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Serine/threonine-protein kinase mTOR
- Tubulin alpha-4A chain
- Tubulin alpha-1A chain
- Tubulin alpha-1C chain
- Tubulin alpha-1B chain
- Tubulin alpha-3E chain
- Tubulin alpha-8 chain
- Tubulin alpha chain-like 3
- Tubulin alpha-3C chain
- Microtubule-associated protein tau
Sequence:
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA
Protein: Zgc:85888 (Q6NW92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLCVLVLALLASASAQRLSRGCGSCDRTQCAPLPAQGCSSGTLRDSCGCCELCAAAEGEFCGGRGVSARRCGSGLECVKPDKKSKSGICVCKSGVPVCGTDGRNYNSGCALRAASARALQEKQPEIRVHNTGRCAQGPEIVTPPGEVWNITGSQVFLSCEAIGVPTPVLTWRKVSGGSEKPVPLPGDKDNLAVQTRGGPEKHQVTGWVLISPLTKAEDGSYECHASNTQGEASAVGSIHVVESISDIPVQMVKDSEL
Protein: Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) (P00540)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:35670744}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 2
- Dual specificity mitogen-activated protein kinase kinase 1
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- Cytoplasmic polyadenylation element-binding protein 1
Sequence:
MPSPLALRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKAELG
Protein: Ankyrin repeat and SOCS box protein 2 (ASB-2) (Q8K0L0)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping. Required for cardiomyocyte differentiation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q96Q27}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:26343497}. Note=Localizes to the Z line in cardiomyocytes. {ECO:0000269|PubMed:26343497}.
Interaction partners:
- Cullin-5
- RING-box protein 2
- Ankyrin repeat and SOCS box protein 17
- Elongin-C
- Elongin-B
Sequence:
MATEISTRGRQRAIGHEEYSLYSSLSEEELLQMAIEQSLADKTRGPTPAEASASSQTNHQPGHFHPWTRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
Protein: Thiosulfate dehydrogenase (EC 1.8.2.2) (Tetrathionate synthase) (D5WYQ5)
Organism: Thiomonas intermedia (strain K12) (Thiobacillus intermedius)
Function: Catalyzes the oxidation of 2 molecules of thiosulfate to tetrathionate, using TsdB as an electron acceptor.
Subcellular location: Periplasm {ECO:0000250}.
Interaction partners:
- Thiosulfate dehydrogenase electron acceptor
- Cytochrome c oxidase subunit 2
Sequence:
MTRKQTPMTLALCALGLFAASAASALAADAPMAPPKSEINAAVGTGAKFTPPPESAIPDDDFGKMVKLGRDIMLDTPKYAKDYVGNTLSCVNCHTDAGRMAGSAPLWAAYVSYPAYRGKNKKVNTFEERLQGCFKFSQNGKAPPLGSKTLVALESYSYWLSKGLPVDEKVAGRGYPNLPEPQQAPDYVRGQKVYEAKCILCHAANGEGQYVNGETVFPPLWGPKSFNWGAGMGSYKNAAKFIYANMPYGMSYSLSPQEAWDVAYFMDAQERPQDPRWQGSVAATRAKFHDSKFSLYGTKVNGKLLGDIGAPKPR
Protein: Glutamate racemase (EC 5.1.1.3) (P22634)
Organism: Escherichia coli (strain K12)
Function: Provides the (R)-glutamate required for cell wall biosynthesis.
Interaction partners:
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- Vitamin B12 transporter BtuB
- Glutaminase 2
- dITP/XTP pyrophosphatase
- Glutaminase 1
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Alanine racemase, biosynthetic
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- UDP-N-acetylenolpyruvoylglucosamine reductase
- UDP-N-acetylmuramate--L-alanine ligase
Sequence:
MATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEAFIVERVVAIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPGAEQLLPVLQRYGFETLEKLAVLG