wanglab/gogpt-training-data huggingface dataset:
Protein: Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) (P80664)
Organism: Struthio camelus (Common ostrich)
Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Subcellular location: Secreted.
Interaction partners:
Sequence:
VPLGVPVALGVPPSRPPCRPVNVTVAAEKDECPQCLAVTTTACGGYCRTREPVYRSPLGGPAQQACGYGALRYERLALPGCAPGADPTVAVPVALSCRCARCPMATADCTVAGLGPAFCGAPAGFGPQ
Protein: Uncharacterized fimbrial-like protein YadK (P37016)
Organism: Escherichia coli (strain K12)
Function: Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Subcellular location: Fimbrium {ECO:0000305}.
Interaction partners:
- Uncharacterized fimbrial-like protein YadL
- Uncharacterized fimbrial-like protein YadM
- Uncharacterized fimbrial-like protein YadC
- Outer membrane usher protein HtrE
- Uncharacterized fimbrial-like protein YadN
- Probable fimbrial chaperone YadV
- Probable fimbrial chaperone YehC
- Uncharacterized fimbrial-like protein YfcR
Sequence:
MHPTQRKLMKRIILFLSLLFCIACPAIAGQDIDLVANVKNSTCKSGISNQGNIDLGVVGVGYFSGNVTPESYQPGGKEFTITVSDCALQGTGDVLNQLHIDFRALSGVMAAGSRQIFANEISSGASNVGVVIFSTQDSANTFNVLNASGGSRSVYPVMSDDMNGSSWKFSTRMQKIDPALSVTSGQLMSHVLVDIYYE
Protein: KLHL32 protein (Q6IQ08)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGRTYLMLDLSKHTFIVVYI
Protein: Nuclear factor 1 (B1AKN8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MKLADSVMAGKASDGSIKWQLCYDISARTWWMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG
Protein: Uncharacterized protein (Q8HCN8)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MKGKECKPRTSERRKRNVLQRVKRNTIKRKWGRTKDGAHSSPIAAKVPYVSRRTRVEVNSSAELSAACFQVSSQAQNHPDDSRYSSGRGLASISTRREYGLSPRQQRGGGDLHGATRGVRNSGKRRSHMVVEEELVWAPRQWSKKFDKFMVDRYLSIPVVGADEPPSVLAAALGGL
Protein: ATP-dependent RNA helicase suv3, mitochondrial (EC 3.6.4.13) (O94445)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exoribonuclease II, mitochondrial
- mRNA degradation protein pet127
- ATP-dependent RNA helicase mss116, mitochondrial
- Exosome complex exonuclease dis3
- ATP synthase subunit a
- Uncharacterized ribonuclease C609.01
- DIS3-like exonuclease 2
- Protein sts5
- Ribonuclease Z 1
Sequence:
MFLETLIHGVTFCVPFFSKSARIHTLSKDVFQQRKFPGNTLWAAALNRFTAYLFASKELSSKQAYLAQDFVNVCKDASVFQNVYYYELKKNILTDLGFSDLKNSDKSLALSKSSSTFDLQKIKKIHDCLLSEYRKYVRYQERIEETRPDLQKQLTDLKNPIEWYPGARKLRRHIIMHVGPTNSGKTHRALERLKTCKKGIFAGPLRLLAHEIYNRLQANGIACNLYTGEEIRNDYPFPQVVSCTVEMCNLSTTFDVAVIDEIQMMADPSRGYAWTQCLLGLQAKEIHLCGEESVVKLVRSIAKMTQDDFTVYRYERLNPLHVAEKSLNGKLSELKDGDCVVAFSRKNIFTLKSKIDQALGKKSAVIYGSLPPEVRNQQASLFNSKSSDENILLASDAIGMGLNLGVKRIVFSDLKKFSGVSTIDIPVPQIKQIAGRAGRHNPNGSKQSAGIVTTLYQKDFAKLNRAMNLPTKNLFNACIGAKDDLFFRYLSLFSDDIPQKLIFDRYFKLAKTTTPFVVSEGALSTFIIEYLDHIKGLTIKDKIKLLGCPVLKHSKYAPLFIREIGCVIAQGKRLQIYDLKSVPLEILERGIPTTETELQQLEQLHKLIVAYMWASIRYPAILQNGAAEKTKAIAEAFLIKGISKLQK
Protein: phosphoenolpyruvate carboxylase (EC 4.1.1.31) (O23946)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- pyruvate, phosphate dikinase
- Citrate synthase
- Citrate synthase
- Citrate synthase
- Citrate synthase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
Sequence:
MAGRKVEKMASIDAQLRLLAPGKVSEDDKLVEYDAVLLDRFLDILQDLHGEDIRETVQECYELSAEYEGKHDPKILEELGKVLTSLDPGDSIVVTKSFSHMLNLGNLAEEVQIAYRRRIKLKKGDFADESSATTESDIEETFKRLVGQLNKSPEEVFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRNCLTQLYAKDITPDDKQELDEALQREIQAAFRTDEIRRNPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYFSQIEDLMFELSMWRCSDELRIRADELHRSSKKDAKHYIEFWKQIPPNEPYRIILGDVRDKLYNTRERARSLLANGFSDIPEEAAFTNVEQFLEPLELCYRSLCACGDRPIADGSLLDFLRQVSTFGLSLVRLDIRQESDRHTDVLDAITKHLDIGSYREWPEERRQEWLLSELRGKRPLFGPDLPKTEEVADVLDTFHVISELPSDSFGAYIISMATAPSDVLAVELLQRECHVKQPLRVVPLFEKLADLEAAPAAVARLFSIDWYRDRINGKQEVMIGYSDSGKDAGRLSAAWQLYKAQEELVKVAKQYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTIHGSLRVTVQGEVIEQSFGEEHLCFRTLQRFTAATLEHGMHPPVSPNPEWRALMDEMAVVATKEYRSVVFQEPRFVEYFRLATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFKHVIQKDIKNLHMLQEMHNQWPFFRVTMDLIEMVFAKGDPGIAALYDKLLVSKELWPFGENLRANYEDTKRLVLQVAGHRDLLEGDPYLKQRLRLRDAYITTLNVCQAYTLKRIRDPDYHVKVRPHLSREYMESSKAAAELVKLNPTSEYAPGLEDTLILTMKGIAAGMQNTG
Protein: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit (EC 2.4.1.-) (Glycosyltransferase Gtf1) (Glycosyltransferase GtfA) (A1C3L9)
Organism: Streptococcus parasanguinis
Function: Required for polymorphic O-glycosylation of serine-rich repeat protein Fap1. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in Fap1. Part of the accessory SecA2/SecY2 system specifically required to export Fap1, a serine-rich fimbrial adhesin encoded upstream in the same operon. The GtfA-GtfB (Gtf1-Gtf2 in this bacteria) complex adds GlcNAc from UDP-GlcNAc to Fap1, attaching the first sugar residue. Cannot use not UDP-Glc as substrate. This subunit has very low glycosyltransferase activity; the GtfB stabilizing protein enhances membrane association, protease resistance and glycosyltransferase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01472, ECO:0000269|PubMed:21862581}. Cell membrane {ECO:0000255|HAMAP-Rule:MF_01472, ECO:0000269|PubMed:21862581}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01472, ECO:0000305|PubMed:21862581}. Note=Cell membrane association requires GtfB (Gtf2), protein is more active and protected from trypsin (PubMed:21862581). {ECO:0000255|HAMAP-Rule:MF_01472, ECO:0000269|PubMed:21862581}.
Interaction partners:
Sequence:
MTIYNINLGIGWASSGVEYAQAYRAQILRSLGMPAKFIFTNMFQSENLEHFTKNIGFEDNEIIWLYGYFTDVKISGTTYKKDDLEATFSQCPTKKEASSDRKLIRYYFENQELYINASLYGENQEYVQRVEYVVKGKLIRKDYYSYTKVFSEFYSPGENGVQLCNRSFYNEDGSIAYEEILSNEKSTFVFSNKICYGLEELLEFMLEDLSLTKSDLILLDRATGIGQVVFENIGAAKLAVVIHAEHFNEKNTDEHNILWNNYYEYQFTNADKVNAFITSTERQKILLEEQFTQYTSLHPKIVAIPVGSLDQLKFPEQSRKSFSMMTGSRLAIEKHIDWLIEGVALAQKRLPELTFDIYGEGGERRKLTELLTKLHAGEFIELKGHKQLDEIYQNYELYLTASTSEGFGLTLMEAVGSGLPIIGFDVPYGNQTFVCSGENGLLIERPKGDDRSRIVQAFADSIYEYFTKFKMADAQQYSYNIAENYKHEKLVERWKDFIEEMLND
Protein: Calcipressin-2 (Calcineurin inhibitory protein ZAKI-4) (Down syndrome candidate region 1-like protein 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Q9JHG2)
Organism: Mus musculus (Mouse)
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Interaction partners:
- Protein phosphatase 3 catalytic subunit alpha
Sequence:
MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDECVTFQLFKSFRRVRINFSHPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWKPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDMEEEEDPKTSPKPKIIQTRRPGLPPSVSN
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (E9PT20)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Adapter molecule crk
- E3 ubiquitin-protein ligase CBL
- Crk-like protein
- Growth factor receptor-bound protein 2
- Breakpoint cluster region protein
- Ephrin type-B receptor 4
- Ras and Rab interactor 1
- SHC-transforming protein 1
- Abl interactor 1
- Retinoblastoma-associated protein
Sequence:
MGQQPGKVLGDQRRPSLPALHFIKGAGKRDSSRHGGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGMRGAAGSTLQAPELPTKTRTCRKTAEQKDAPDALELLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERLLPKDKKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQSERRGASEDDGREISNGPPALTSDAVEPTKSPKASNGAGVPNGAFREPGNSGFRSPHVWKKSSTLTSSRLAAAEEESGLSSSKRFLRSCSASCMPHGVRDTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVAKSTATPPPRLVKKTEEAAEDVFKDTESSPGSSPPSLTPKLLRRQVPASPSSGPSHKDEATKGNASGMGTPATAEPAAPSNKAGLSKASSEEPRARRHKHSSESPGRDKGRLSKLKPAPPPPPSSTGKAGKPAQSPSQDVAGEAGGATKTKCTSLSVDAVNSDPTKAGQPGEGLRKSVPPSVPKPQSATKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR
Protein: Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (P56289)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P23301}.
Interaction partners:
- Probable deoxyhypusine synthase
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein RACK1
- Deoxyhypusine hydroxylase
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein bL28m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS9m
Sequence:
MAEEEHVDFEGGEAGASLTFPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHIVALDIFNGRKYEDMSPSTHNMDVPVVKRDEYQLVNIDDGYLNLMTTDGTTKDDVRLPEGELGNEIEEGFDEGRDLIITVVSAMGEETALACRDAPSS
Protein: Solute carrier family 7 member 2 (A0A1W2PR06)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
RGFIGTPAPPVCDSKFLLSPSSDVRMIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Protein: Small ribosomal subunit protein eS26 (40S ribosomal protein S26) (DS31) (P13008)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62854}. Cytoplasm {ECO:0000305|PubMed:23636399}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P49171}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49171, ECO:0000250|UniProtKB:P62854}.
Interaction partners:
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein uS7B
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL28
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein uL30
Sequence:
MTKKRRNGGRNKHNRGHVKPVRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDITEASIWDSYVLPKLYAKLHYCVSCAIHSKVVRNRSREARRIRTPPLRSFPKDMARNNQNRK
Protein: Exocyst complex component SEC8 (AtSec8) (Exocyst complex component 4) (Q93YU5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in secretory processes during cell plate initiation, cell plate maturation and formation of new primary cell wall.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19895414, ECO:0000269|PubMed:24307681}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:20870962}. Secreted, cell wall {ECO:0000269|PubMed:20870962}. Secreted, extracellular exosome {ECO:0000269|PubMed:24307681}. Note=During cytokinesis, localizes to the nascent cell plate and later to the cell plate insertion site and along the post-cytokinetic wall (PubMed:20870962). Shuttles from the cytoplasm to the exocyst-positive organelle (EXPO) in the presence of EXO70E2 (PubMed:24307681). {ECO:0000269|PubMed:20870962, ECO:0000269|PubMed:24307681}.
Interaction partners:
- Exocyst complex component SEC3A
- Exocyst complex component SEC5A
- Exocyst complex component SEC15B
- Exocyst complex component SEC15A
- Exocyst complex component SEC5B
- Exocyst complex component SEC10b
- Exocyst complex component EXO84B
- Exocyst complex component SEC6
- Exocyst complex component SEC10a
- Exocyst complex component EXO70A1
Sequence:
MGIFNGLPVPSDKTYLREELARIDESWAAARFDSLPHVVHILTSKDREADIHILKEQSDVVEEVVDEVVHAYHGGFNKAIQNYSQILRLFSESTEKIGDLKHDLAEAKQSLGARNKQLHQLWYRSVTLRHIISLLDQIEGIAKVPSRIEKLIADKQFYAAIQVYLQSSLMLEREGLQTVGALQDVRSELTKLRGALFFKILDDLHAHLYNRGEYSSVASSIYERDDEVPTTTAVAASRMSSQPLSRRTRTLKGDSQFGVRGLTNGSYRTASNDESSSFDGHDEEDSVEHDESTADTARNGTDSKLLSHQLPPWLSDSTPDEFIEAVRKSDDPLHVKYLQTLVQCLCMLGKVAAAGAIICQKLRPTIHEIIISKIKAHLETTNLSKSACSQGDRSVAAGLHLIKGQSEAYRLSKEKPQNGISNSGTHLAVSPVSPLMAPGGKAQAAAKELLDSILDTIVKIFENHVVIGELLEMKASQHDINTPRSLPTDVNWNTESEASQATGGYTISFPLTVLQSECQQLICEILRATPEAASADAAAQTAKLAKKAPKKDKRDAPEDGLTFTFRFTDATVSISNQGADLIRQGWGKRAPNASLEGYGSAAVLPEQGIYLAASIYRPVLQFTDKITSMLPKKHSQLVNDGLLTFTENFVKDHLLPTMFVDYRKGVQQAISSAAAFRPRAHTTTYTATVEKGRPILQGLLAIDLLAKEVLGWAQAMPKFATDLVKYVQTFLERTFERCRTSYMEAVLEKLSYMLIGRHDIEKLMRLDAASACLPSTLGHAVSHSEAVGTEVELSDLFLSLRPIKQDNLIRDDNKLILLASLSDSLEYVADSIERLGQAVPRVASQAEGNSRNQAASPRNLASFADEYRKLATDCLKVLRVEMQLETVFHLQEMTNREYLEDEDAEEPDDFVISLTSQITRREEGMAPFISGEKRNYVFGGISGIAANASIKALADMRSINLFGVQQICRNTIAVEQAMAAIPYIDGETVQQNLDRVRTYFELLNMPFEALLAFIAEHDQMFTPTEYSNLLKVNVPGRDTPSDAQSRLLEILSH
Protein: Homogentisate 1,2-dioxygenase (HGDO) (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase) (Q6EMI9)
Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
Function: Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of 2,5-dihydroxyphenylacetate to yield maleylacetoacetate.
Interaction partners:
Sequence:
MTRDTSPDLHYLSGFGNEFASEALPGALPVGQNSPQRAPYGLYAELLSGTAFTMARSELRRTWLYRIRPSALHPRFERLARQPLTAPLGAINPNRLRWSPQPIPAEPTDFIEGWLPMVANAPAQKPAGVSIYIYCANRSMERVFFNADGELLLVPEQGRLRIATELGVMEVGPLEIAVIPRGMKFRVELLDGQARGYIAENHGAPLRIPELGPIGSNGLANPRDFLTPVAHYEEAEGPVQLVQKFLGEHWACELQHSPLDVVAWHGSNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANMDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLISGAYDAKAEGFLPGGASLHGVMSAHGPDAETCEKAIAADLAPHKIDNTMAFMFETSQVLRPSQQALECPQLQADYDSCWATLPSTFNPNRR
Protein: M-phase phosphoprotein 6 homolog (Exosome-associated RNA-binding protein MPP6) (P53725)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin. Binds RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16702403, ECO:0000269|PubMed:18591258, ECO:0000269|PubMed:19046973}. Note=Colocalizes with the nuclear exosome and ribosomes.
Interaction partners:
- Exosome complex component RRP45
- Exosome complex component RRP42
- Exosome complex component SKI6
- Exosome complex exonuclease DIS3
- Exosome complex component MTR3
- Exosome complex component RRP4
- Exosome complex component CSL4
- Exosome complex exonuclease RRP6
- Exosome complex component RRP46
- Exosome complex component RRP43
Sequence:
MSANNGVTGKLSSRVMNMKFMKFGKTDDEESSNSNTPSNINSDVEPIEQKGKLFGLDDSAWDLNSYKDDLKKISGKEKKKVKRVVYKKRPNLIISNVGYSELRKPEGVISGRKTFGDNSDDSGSRKRKFDEGEQNEDEKRDAKDKEFTGSQDDGEDEYDLDKLFKDSIKKKKTNHNGKNKNRNSKK
Protein: Uncharacterized protein Rv2084 (P9WLK1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv2083
- Uncharacterized protein Rv2082
Sequence:
MPVSDDSSSAFDLICAEIERQLRGGELLMDAAAASELLLTVRYQLDTQPRPLVIVHGPLFQAVKAARAQVYGRLIQLRHARCEVLDERWQLRPTGQRDVRALLIDVLNVLLAAITAAGVERAYACAERRAMAAAVVAKNYRDALGVELQCNSVCRAAAEAIHALAHRTGATEDADCLPPVDVIHADVTRRMHGEVATDVVAAGELVIAARHLLDPMPRGELSYGPLHEGGNAARKSVYRRLVQLWQARRAVTDGDVDLRDARTLLTDLDSILREMRTAATIQQSGTAGDGGGGRRQDSRRRNGPRRPARRGTSRGRRCAPRVAIGWHTPIGDPLAVEGVEEIGASLPGRESTPSDDGGSLHPSGRPRRVHRRRWCGLGLC
Protein: NEK6-subfamily protein kinase (EC 2.7.11.34) (Q5TBG2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHR
Protein: Serine/threonine protein phosphatase, putative (Q57Y37)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Protein phosphatase methylesterase 1
- TAP42-like protein
- Serine/threonine-protein phosphatase 2A activator
Sequence:
MKAQRYASVLTLDNLTGRLVVVGDIHGCLAQLQGLLRAVSFKQGSDTLVAVGDLVNKGPDSFGVVRLLKRLGAHSVLGNHDVKLLKLVKKIREKGPLNERDTKSSLAPFALTVPVDVEVYLSQLPHIIRIPAHNVIVTHGGLHPQRPLDCQYIDEVTTLRNLIEKEQKAGGVTLVATPETKDGGVPWASLWRGPETVVFGHDSRRGLQEQYRPLAIGLDSGCVYGGRLSAAVFPGGHIVSVSGWRREAKL
Protein: Transcriptional regulator MET31 (Methionine-requiring protein 31) (Q03081)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Auxiliary transcriptional regulator of sulfur amino acid metabolism. Involved in the transcriptional activation of MET28.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcriptional activator of sulfur metabolism MET28
- Transcriptional activator of sulfur metabolism MET4
- Centromere-binding protein 1
- Transcriptional regulator MET32
- Adenylyl-sulfate kinase
- Sulfate adenylyltransferase
- F-box protein MET30 subunit MET30)
- Glutamate--cysteine ligase
- General control transcription factor GCN4
- Myb-like DNA-binding protein BAS1
Sequence:
MKLAQDMNVDEIFLKQAAEAIAVISSSPTHTDPIIRELLHRIRQSSPLSAVIPAPENVLKAGEPENMARGLIRIPETQTKRTGGNNHSKEGAQLYSCAKCQLKFSRSSDLRRHEKVHSLVLPHICSNCGKGFARKDALKRHSNTLTCQRNRKKLSEGSDVDVDELIKDAIKNGTGLL
Protein: 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type I DHQase) (Type I dehydroquinase) (DHQ1) (P05194)
Organism: Escherichia coli (strain K12)
Function: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsilon-amino group of a Lys-170 at the active site.
Interaction partners:
- Quinate/shikimate dehydrogenase
- 3-dehydroquinate synthase
- Shikimate dehydrogenase
- Shikimate kinase 1
- Inner membrane transport protein YdiN
- Chorismate synthase
- Shikimate kinase 2
- Isochorismate synthase MenF
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
- 3-phosphoshikimate 1-carboxyvinyltransferase
Sequence:
MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
Protein: Exoribonuclease 2 (EC 3.1.13.1) (Exoribonuclease II) (RNase II) (Ribonuclease II) (P30850)
Organism: Escherichia coli (strain K12)
Function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. RNases 2 and R (rnr) contribute to rRNA degradation during starvation, while RNase R and PNPase (pnp) are the major contributors to quality control of rRNA during steady state growth. This RNase is required to decrease expression of RNase PH (rnp) at 42 degrees Celsius during starvation, which in turn represses rRNA degradation.
Subcellular location: Cytoplasm.
Interaction partners:
- Ribonuclease E
- Polyribonucleotide nucleotidyltransferase
- Ribonuclease T
- Ribonuclease D
- Ribonuclease 3
- Poly
- Ribonuclease G
- ATP-dependent RNA helicase RhlB
- Ribonuclease BN
- Oligoribonuclease
Sequence:
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSKLDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
Protein: CalS11 (Q8KNF1)
Organism: Micromonospora echinospora (Micromonospora purpurea)
Interaction partners:
Sequence:
MDSGDGQDLRAFVHDSPEETETTQRLTKLLTNSPIPTEELVNNLPLFLRRHQMTDLLSMDALYRQVLDVPGVIMEFGVRFGRHLGTFAALRGVYEPYNPLRRIVGFDTFTGFPDVNDVDRVGPTAYQGRFAVPGGYPAYLKEVLDAHECSDFFGHVTQRSVLVEGDVRETVPRYLAENPQTVIALAYFDLDLYEPTKAVLEAIRPYLTKGSIVAFDELDNPKWPGENIAMRKVLGLDHAPLRLLPGRPAPAYLRWGD