wanglab/gogpt-training-data huggingface dataset:
Protein: Protein kinase C-like 1 (PKC) (EC 2.7.11.13) (Tetradecanoyl phorbol acetate-resistant protein 1) (P34722)
Organism: Caenorhabditis elegans
Function: Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp-29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir-1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt, downstream of lin-3 and receptor let-23 and phospholipase plc-3.
Interaction partners:
- GLH-binding kinase 1
- Stress-activated protein kinase JNK
- Stress-activated protein kinase jnk-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
- non-specific serine/threonine protein kinase
- Guanine nucleotide-binding protein alpha-12 subunit
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
- Protein nipi-3
- Small ribosomal subunit protein RACK1
- Cell death protein 3
Sequence:
MAQAENACRLKLLRADVPVDLLPAGCSATDLQPAVNVKEKIEVNGESRLVQKKKTLYPEWEKCWDTAVAEGRILQIVLMFNQTPVVEATMRLEDIISKCKSDAITHIWINTKPNGRILAQTRHLKNAPDDDHPVEDIMTSRSNSGPGIQRRRGAIKHARVHEIRGHQFVATFFRQPHFCSLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTKETMALKERFKVDIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMSNLCGVNQKQLSEMYHEIKRGTHATASCPPNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKETDEYMDNIWGGGDGPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTPVHDKNLLASIDPEAFLNFSYTNPHFSK
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2) (O89040)
Organism: Rattus norvegicus (Rat)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel, subfamily M, member 5
- Guanine nucleotide-binding protein subunit alpha-15
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Sequence:
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL
Protein: Origin recognition complex subunit 1 (Q96F82)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365058}.
Interaction partners:
Sequence:
MAHYPTRLTTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDDDENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPACDSNINAETIIGLVRVIPLAPKDVVPTNLKNEKTLFVKLSWNEKKFRPLSSELFAELNKPQESAAKCQKPVRAKSKSAESPSWTPAEHVAKRIESRHSASKSRQTPTHPLTPRARKRLELGNLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSPSKRSQPDKLQTLSPALKAPEKTRETGLSYTEDDKKASPEHRIILRTRIAASKTIDIREERTLTPISGGQRSSVVPSVILKPENIKKRDAKEAKAQNEATSTPHRIRRKSSVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDSSSDEEEASTPPLPRRAPRTVSRNLRSSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSLAAQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERIMMNRVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE
Protein: Mitotic cyclin (Q57WP1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine/threonine-protein kinase, putative
- Serine/threonine-protein kinase PLK
- Cyclin-dependent kinases regulatory subunit
- Cell division control protein 2 homolog 1
- Telomerase-associated protein, putative
- Ubiquitin, putative
- non-specific serine/threonine protein kinase
- Uncharacterized protein
- Uncharacterized protein
- Cell division cycle protein, putative
Sequence:
MSYNTSSSSDSLLCEIDVNIQQQLDNSNFFLPVPKHLWNVQSKKGKQRCQGGGTSPKNTAQSNQPSTEMTCVMLQKSMRNALCNLELMYTNDTERLKQRLSEEFHRLRESAAERTRQLIDLSTKAQPLSYRVLFVLNLRRWMLCRGFEFALQDLKDWLRLALLLRETDTLHFLRECTKKLGPYARQRVEDALILHGSDIDSVCQVVMDIPVPTDETTTFGGPYYNLTLNDLIAMGDEDTHSVHVVNAQHTMPSHVREGLVEWMLLVNVELNLQLETFFLAVSILDRYLLRATIQPDREYLTAYAILLLASKVEEKCLFPLRDSVRLCGKTYKVGVLIATTNRIFEVLDCNVVYATLSNVGFGFLWQQEPVACEKQYSFLTYILTTLAIRTQYRQYRLSALAAAAVYVSRLRFNIPTGRPCDEVVVLLPVIKDAISCNISARSGGVYDLFKRSCFHEASRFPLPDLLYGL
Protein: Geminin DNA replication inhibitor (H7C608)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEV
Protein: Ral guanine nucleotide dissociation stimulator-like protein (Q9GR11)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSQNVADSLPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKSVVSTNTSLTNTTASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTPQSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDDPDRFTLAQVLPDKELVMPKNANVYYAVNTNYNLNFILRPRKEEGVAGS
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (A0A2R8Y6Y1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKNGVSLLLPRLEYNGVISAHHNLRLQ
Protein: CXXC-type zinc finger protein 4 (Q0VFP6)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Acts as a negative regulator of the Wnt signaling pathway required for anterior neural structure formation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9EQC9}.
Interaction partners:
- ATP synthase-coupling factor 6, mitochondrial
- Segment polarity protein dishevelled homolog DVL-3
Sequence:
MHRNDSQRLGKPGGAPESLQMANNNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNNSSGAGGNPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF
Protein: G-protein coupled receptor 6 (Sphingosine 1-phosphate receptor GPR6) (P46095)
Organism: Homo sapiens (Human)
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:19059244}; Multi-pass membrane protein {ECO:0000305|PubMed:19059244}. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.
Interaction partners:
- Glutamate receptor ionotropic, kainate 5
- Nuclear receptor subfamily 2 group E member 1
- G protein-coupled receptor 88
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
Protein: Nuclear pore complex-interacting protein family member B9 (F8W1W9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVKLSIVLTPQFLSHDQSQFTKELQQHVKSVTCPCEYLRKVINSLAVYRHRETDFGVGVRDHPGQHGKTPSPQKLDNLIIIIIGFLRRYTFNILFCTSCLCVSFLKTIFWSRNGHDGSMDVQQRAWRSNRSRQKGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINRHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAAEHRHSSGLPYWLYLTAETLKNRMGRQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSVDDNIKECPLAPLPPSPLPPSVDDNLKECLFVPLPPSPLPPSVDDNLKECLFVPLPPSPLPPSVDDNLKTPPLATQEAEVEKPPKPKRWRVDEVEQSPKPKRQREAEAQQLPKPKRRRLSKLRTRHCTQAWAIRINP
Protein: Protein FAM83C (Q9BQN1)
Organism: Homo sapiens (Human)
Function: May play a role in MAPK signaling.
Interaction partners:
Sequence:
MFGGPGPGVLGAQGMAGPLRGRVEELKLPWWRESSPLVLRHSEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEASGPDRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCLYAESQPVEGFCGGEDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQYPKAQGSRVPLETNSSARPARRAPDERRQTLGHSQLDLITKFGPFRGEGPGPNGLPISSPARTAGAGSGDEKRLTLGHSKLDLITKYHQLHGARQGTEPGGPKGGHLNGGNSDLVRDEKRLTLGHSKLDLITKYNKSKFKQLRSRFES
Protein: Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (F8W3Z0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MARFGDEVPARYGGGGGGGSGQGGPGRGGSRQGGPPGAQRMYKQSMAQRARTMAIYNPIPVRQNCLTVNRSLFLFSEDNIVRKYAKKITEWPPFEWMILTTIIANCIVLALEQHLPVGDKTPLSERLEETEPYFIAIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSSVGSELDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGVLLFVAILMFAIIGLEFYMGKFHTTCFNTITGEMYDERPCGARTCDANNTQCQGYWLGPNYGITQFDNVLFAVLTVFQCITMEGWTDMLYYSNDALGSAWNWMYYVPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWICKAEEVILAEDDNDTGSRRRPTLKKNKADLLNPQEGVDHMGDSVGSPFARGSMSGKGDETPFSKKERRLRFLIRKMVKTQAFYWTVISLVALNTLCVAVVHYDQPELLSDFLYYAEFIFLGLFMSEMLIKMYGLGTRPYFHSSFNCFDCAVIVGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFELGTPPTNFDTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDKGMIFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEATTQKMALQKAKEVAEVSPLSAANLSIAAKEQQKNSKGSKSVWEQRTSEIRRQNLMTSREALYNELDAEDHWKMNYRNRPDVKTHLDRPLVVNPQENRNNNTNKPRPDDPNPQERSEEHPSRSHHHHSHHHHHHHHHTHHSSRQSLHLPELAETGFECDVEGAGEHRRPRHHQHRRRDEDGGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEGSLSTARPIQPGLPHTESQYSEDLDNLRNSSKMAIHDPDPDLYDPYYDPEQANNLLNLRGPDLHDSSLILTDSSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEKKEEEEDDGGDEEGHKRIPPFSSCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSSIALAAEDPVSQDSERNKVLRYFDYVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLDFVVVSGALVAFAFTGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFARDCRGEYLVYERDNEVKSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVRNFFRDAWNIFDFVSVIGSITDILVTELVNNFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAILFFIYAIIGMQLFGNLALDDEGAINEHNNFRTFFMALMLLFRSATGEAWHDIMLSCLGGMPCEPEEVGSECGSNVAYAYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQEGGPGLNGLPELPQEPVNSLPPEVGMNESQSWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQTITDTSPMRRSTSSLVHGRSGRGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLARYTDADTGLGTDLSTTTQSGDLPPKERERERGRAKDRRHHHHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSRSPSEGRGHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPHVTYSPAVRKPPYGSPGQGRLRSPSPRNFSPPGHEPPYHRPPSRHASPHPGSPRHASPRSPRHTSPRSPRHGRWGPPDSLEGDGTFYERDYEYERHHEPPAYEQSLSQGNPHPHSHPHPRSPRTARHGPQPHPRRMPNGYRSSSPSPHRRGPHPGPHRPPHGRGPRKGLHEQYSETDEDDWC
Protein: INO80 complex subunit B (C9JKY0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQP
Protein: Uncharacterized protein C31G5.21 (Q92363)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Pre-mRNA-splicing factor cwf22
- Pre-mRNA-splicing factor slu7
- Pre-mRNA-splicing factor spp42
Sequence:
MDYVGGSLKLKNVKKKPLKKKKKDSKKLAEKVQEHSSRDKSPLEENGVSTYQMLRSKDTDSAMPMTEAQKHFESVQEQRLLQKAKNERLKTHKDRIDEYNRLLESQSEHFDMPKIGPG
Protein: Egg cell-secreted protein 1.5 (Q9FGG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:23180860}. Secreted {ECO:0000269|PubMed:23180860}. Note=Secreted via vesicle exocytose upon sperm arrival, especially in the apical region of the degenerating synergid cell.
Interaction partners:
- Protein RKD1
- Protein RKD2
- Eukaryotic aspartyl protease family protein
- Probable aspartic protease At2g35615
- GTP-binding protein-like protein
Sequence:
MATKSTSKPLLLSFLMMSYLISTFHVITVAEGRTLQFTKMATDHSGAGNLMDCWNAGLELKSCTDEIVKFFLSQTGTSEPPVKGGIDKDCCGAIGLVVKDCWSVMFTSLGLTTMEGNNLREYCEFQAEKSELSPSPAPETLALSPVEITYPGLDY
Protein: Large ribosomal subunit protein uL3y (60S ribosomal protein L3-2) (P22738)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL10x
- Probable ribosomal protein
- Large ribosomal subunit protein eL38z/eL38y
- At1g43860
- Large ribosomal subunit protein eL43y
- Large ribosomal subunit protein uL10y
- Small ribosomal subunit protein uS2y
Sequence:
MSHRKFEHPRHGSLGFLPRKRASRHRGKVKAFPKDDPTKPCRLTSFLGYKAGMTHIVRDVEKPGSKLHKKETCEAVTIIETPPMVVVGVVGYVKTPRGLRSLCTVWAQHLSEELRRRFYKNWAKSKKKAFTRYSKKHETEEGKKDIQSQLEKMKKYCSVIRVLAHTQIRKMKGLKQKKAHLNEIQINGGDIAKKVDYACSLFEKQVPVDAIFQKDEMIDIIGVTKGKGYEGVVTRWGVTRLPRKTHRGLRKVACIGAWHPARVSYTVARAGQNGYHHRTEMNKKVYRVGKVGQETHSAMTEYDRTEKDITPMGGFPHYGIVKEDYLMIKGCCVGPKKRVVTLRQTLLKQTSRLAMEEIKLKFIDAASNGGHGRFQTSQEKAKFYGRTIKA
Protein: Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLACS2) (VLCSH1) (mVLCS-H1) (EC 6.2.1.-) (E9Q9W4)
Organism: Mus musculus (Mouse)
Function: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (By similarity). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (By similarity).
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Y2P4}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000305|PubMed:15699031}; Multi-pass membrane protein {ECO:0000255}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250|UniProtKB:Q9Y2P4}.
Interaction partners:
Sequence:
MLLSWLTGLGAGLLSLHFLQKLLFPYFWDDFWYLLKVVRYGIQMEMYKLRGELVTVLDKFLSHTRKQPRKAFIIYEGDVYTYEDVDKRSNRIAHALLNHSSLKRGDVVALLMSNEPDFVHVWFGLAKLGCVVAFLNSNLRFDSLLHCINTCEPTAVVVGGDLLGSIEEILPSLPKHVRVWGMKDSVPEGIDSLQEKLSLASDEPVPPSHHVTSSLKSTCLYIFTSGTTGLPKAAVISQLQVLKGSVGLWAFGCTADDIIYITLPLYHSSGSLLGIGGCVELGATCVLKKKFSASQFWNDCKKYNVTVFQYIGELCRYLCKQPQREGEKDHRVRLAVGNGLSSDVWRQFLDRFGNIKMCELYGATEGNIVFMNHTGKIGSVGRANFFYSLFFSFELIKYDFQKDEPWRNGQGWCSCVRKGEPGLLISRVNKKNPFFGYAGSDTHTKSKLLFDVFRKGDVYFNTGDLMFQDQENFVYFWDRLGDTFRWKGENVATTEVADVLGRLDFIQEANVYGVRVPGYEGKAGMTSVILKPNKSLDLEKMYNQVVTSLPAYACPLFLRIQDKMETTGTFKLKKLQLVEEGFDPLKISDPLYFMDNLKKSYVPLTEEIYNQIMSEEVKL
Protein: E3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1) (O76050)
Organism: Homo sapiens (Human)
Function: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
Interaction partners:
- Protein jagged-1
- E3 ubiquitin-protein ligase MIB2
Sequence:
MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (B5BM27)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKFPFLFLFLIILIDTTIDAASPTSTQGSVTVRRRQRKIVVREFCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQIDGHLIIEHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQTSMKCERCSPECETCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKPETSEEAEAVQYENEEVSQKETCL
Protein: Carbonic anhydrase (Q8I102)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPGLERILNGVIRFRQTVRKDLVKQFERIRDNPHPTAVFFTCMDSRMLPARFSAVIDPEDKLNVEDKLSQINTLQQLENVASHGFLKEFLVSQTVDLHAMWFDIYTGEMHMFSKPNKQFVLVDESNVEELIDEVEKHQT
Protein: Probable xyloglucan glycosyltransferase 12 (EC 2.4.1.-) (Cellulose synthase-like protein C12) (AtCslC12) (Q9ZQB9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable beta-1,4-glucan synthase rather involved in the synthesis of the xyloglucan backbone than cellulose. Seems to work simultaneously with xyloglucan 6-xylosyltransferase. Xyloglucan is a noncellulosic polysaccharides of plant cell wall and consists of a glucan backbone substituted by xylose, galactose and fucose.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9LJP4}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- tRNA/rRNA methyltransferase
- Cellulose synthase-like protein B6
- ceramide glucosyltransferase
- RNI-like superfamily protein
- At5g19070
- AT-hook motif nuclear-localized protein
- CMP-sialic acid transporter 2
- Cellulose synthase-like protein D5
- Probable xyloglucan galactosyltransferase GT12
- Lysine histidine transporter-like 8
Sequence:
MAPKFEWWAKGNNNNTRKGTPVVVKMENPNNWSMVELESPSHDDFLVRTHEKSRNKNARQLTWVLLLKAHRAAGCLTSLGSALFALGTAVRRRIAAGRTDIEISSSGVGSLQKQNHTKKSKLFYSCLKVFLWLSLILLGFEIAAYFKGWSFGTSKLQLQFIFNKGFFDWVYTRWVLLRVEYLAPPLQFLANGCIVLFLVQSLDRLILCLGCFWIRFKKIKPVPKPDSISDLESGDNGAFLPMVLVQIPMCNEKEVYQQSIAAVCNLDWPKGKILIQILDDSDDPITQSLIKEEVHKWQKLGARIVYRHRVNREGYKAGNLKSAMNCSYVKDYEFVAIFDADFQPLPDFLKKTIPHFKDNEEIGLVQARWSFVNKEENLLTRLQNINLAFHFEVEQQVNSVFLNFFGFNGTAGVWRIKALEDSGGWLERTTVEDMDIAVRAHLHGWKFVFLNDVECQCELPESYEAYRKQQHRWHSGPMQLFRLCLPAVIKSKISIGKKFNLIFLFFLLRKLILPFYSFTLFCIILPMTMFVPEAELPAWVVCYIPATMSFLNILPAPKSFPFIVPYLLFENTMSVTKFNAMVSGLFQLGSAYEWVVTKKSGRSSEGDLAALVEKDEKTTKHQRGVSAPETEAEKKAEKTKRKKKKHNRIYMKELSLAFLLLTAATRSLLSAQGIHFYFLLFQGISFLLVGLDLIGEQVE