wanglab/gogpt-training-data huggingface dataset:
Protein: DExH-box ATP-dependent RNA helicase DExH11 (EC 3.6.4.13) (AtHELPS) (Protein SKI2 homolog) (AtSKI2) (F4JAA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Involved in the regulation of potassium deprivation stress response.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22511887}.
Interaction partners:
- Tetratricopeptide repeat protein SKI3
- WD repeat-containing protein VIP3
- Exosome complex component RRP4 homolog
- Exosome complex component RRP45B
- Exosome complex exonuclease RRP46 homolog
- Exosome complex component RRP45A
- Ribosomal RNA-processing protein 42
- Inactive exonuclease DIS3L2
- Ribosomal RNA-processing protein 43
- Protein RRP6-like 2
Sequence:
MNKVEAGNELGFRVGFSGHGGHLRVEPFYTAERDDALNSLPDFVSPPAFAKETKESIKKHIEEKYLIPRLEPDQFSAEKAENQWDFDWFSRVKMPLQPSLPRSVVVPTWELPFRRQKEDTENGAWEPKSVEVDLSEQMYGDQDSGFFPRMVGPPKDFLRGSVNNRPFRPGGLEDSQSSERVLPEGVSSGQWVQELLNGGPAQTVPPSFKQSLDLGDLMPYPQTWSVYEDHSSHGNASDENSSKLSIQFDDLFKKAWEEDTFSELEGDDHTAGSESPKAEAEPDAKASISNEVSKGLETDVTVLDEILSSAKTAIMSEEAVTGSSDKQLRKEGWATKGDSQDIADRFYELVPDMAIEFPFELDNFQKEAICCLEKGESVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGLLTGDVSIRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINFVLLSATVPNTFEFADWIGRTKQKEIRVTGTTKRPVPLEHCLFYSGELYKVCENEVFLSKGIKDAKDSQKKKNSNAVSVAPKQQMGSSAHQDGSKSQKHEAHSRGKQNKHSSVKDVGKSSYSGNSQNNGAFRRSAASNWLLLINKLSKMSLLPVVVFCFSKNYCDRCADALTGTDLTSSSEKSEIRVFCDKAFSRLKGSDRNLPQVLRLQSLLHRGIGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDALRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKTGTVVVMCRDEVPDESDLRRVIVGSATRLESQFRLTYIMILHLLRVEELKVEDMLKRSFAEFHAQKKLPEKQQLLMIKRSLPTKHIECIKGEPAIEDYYDMYMEANEYNNKMSEAVMQSPYAQSFLVQGRVVVMKSGMGIDNLLGIVLKGPSNTNRQYVVLVIKSEIPPPEKNMVSIGKKSSDPSQGYFIAPKSKRGFEEEFYTKPSSRKGPVVIKIELPYHGVAAGVGYEVKGFDNKEFLCICDSKIKIDQVRLLEDGNKAAFSQTVQQLLDLKSDGNKFPPALDPVKDLKLKDAELVETYYKWTNLLQKMSMNKCHGCVKLEEHMKLAREIKKHKTDLKDLEFQMSDEALLQMPAFQGRIDVLKNIGCIDDDLVVQIKGRVACEMNSGEELICTVCLFENQFEELEPEEAVAIMSAFVFQQKNTSAPTLTPKLAKAKQRLYDTAIRLGELQAQYNLQIDPEEYAQENLKFGLVEVVYEWAKGTPFAEICELTDVPEGLIVRTIVRLDETCREFKNAAAIMGNSALHKKMDAASNAIKRDIVFAASLYVTGV
Protein: EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) (Q8BYW9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Protein O-glucosyltransferase 1
- GDP-fucose protein O-fucosyltransferase 1
Sequence:
MLMLLVFGVLLHEVPLSGQDKAHSEADDAPGKALYDYSSLRLPAEHIPFFLHNNRHVASVCREDSHCPYKKHLENLNYCWGYEKSCAPEFRFGSPVCSYVDLGWTDTLESAQDMFWRQADFGYARERLGEIRTICQPERASDSSLVCSRYLQYCRATGLYLDLRNIKRNHDRFKEDFLQGGEIGGYCKLDSHALVSEGQRKSPLQSWFAELQGYTQLNFRPIEDAKCDIVVEKPTYFMKLDAGINMYHHFCDFLNLYLTQHVNNSFSTDVYIVMWDTSTYGYGDLFSDTWKAFTDYDVIHLKTYDSKKVCFKEAVFSLLPRMRYGLFYNTPLISGCQNTGLFRAFSQHVLHRLNITQEGPKDGKVRVTILARSTEYRKILNQDELVNALKTVSTFEVRVVDYKYRELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAVFELYNCEDERCYLDLARLRGIHYITWRKPSKVFPQDKGHHPTLGEHPKFTNYSFDVEEFMYLVLQAAEHVLQHPQWPFKKKHDEL
Protein: Contig An01c0080, genomic contig (A2Q855)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKFSHSIQFNAVPDWSAYYLAYSNLKKLIYSLEQEVHHRSAGHEHADVEQAPLLDGGSLNTDAIFRRALDAELEKICSFYQSKEAEIFTEVEDVLRDAEEYAHRADTMNVDPMSDAMIKGRTASSSSRQRPGSIVRRVPSNQERRHSAFSETLADDDDDDADSDDEPGTLSNQYRPQSHGAESSNPDGSRTDDMRDSVLWGADSRLLGYSGPSAHRGGAPDEHFSDPIVVDLYNAGLSLKKRAVAAYVSICGLKSYIQLNKTGFSKALKKYDKILDRNLRREYVNSVVSLTYPFKDSTMEKVDDNIRKVEEVYANVVTTGNIPLAKRELRLHLREHVVWERNTVWREMIGIERKAQAANVGIRRTLLGGDEDPSKARRQGDEQEVMPKMIRTPFGTIRIPQWLCSLSLVTLVLILLVFGILLSVPIMEKPEQQNCLAMLVFVSLLWATEVIPLFVTSLLIPFLVVMLRIMLSDNKPHERLGPKEATAAAFSAMWTPVIMLLLGGFTIAAALSKYDIARRMAMFVLSKAGSNPNILLLTNMFVSMFLSMWISNVASPVLCYSIIQPLLRNLEPDSSFAKSLVLGIALAANVGGAASPIASPQNIIALQNIYPSMSWGTWFFISLPVCILSIVAIWMLLVLTFKPGRETAVAIRPLKDKFTGVQWFISIVTLSTIALWCGSHQLEHIFGDMGVIAIIPMVLFFGTGILNKEDFNNFLWTIIILAAGGLCLGKAVTSSGLLHTLANAIRMRVEHLSLYGVLLVFSALILVIATFISHTVAALIMLPLVRQIGLGMDDPHPNLLVMASALMCSVAMALPTSGFPNMTAIMTEVPQTGQRYLQVRHFFTRGIPASLMSFAVIVTVGYGLMYIAGLHAARSGPGMLL
Protein: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase) (MTAN) (EC 3.2.2.9) (5'-deoxyadenosine nucleosidase) (DOA nucleosidase) (dAdo nucleosidase) (5'-methylthioadenosine nucleosidase) (MTA nucleosidase) (S-adenosylhomocysteine nucleosidase) (AdoHcy nucleosidase) (SAH nucleosidase) (SRH nucleosidase) (P0AF12)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Can also use 5'-isobutylthioadenosine, 5'-n-butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza-adenosylhomocysteine as substrates in vitro.
Interaction partners:
- S-ribosylhomocysteine lyase
- Polyamine aminopropyltransferase
- DNA-cytosine methyltransferase
- Vitamin B12-binding protein
- Probable autotransporter YfaL
- UPF0126 inner membrane protein YadS
- S-adenosylmethionine synthase
- Quinolinate synthase
- Transcriptional regulator LsrR
- Autoinducer-2 kinase
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
Protein: Putative pyruvate decarboxylase C3G9.11c (EC 4.1.1.1) (O42873)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Alcohol dehydrogenase
- Putative aldehyde dehydrogenase-like protein C922.07c
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Probable transketolase
- Alcohol dehydrogenase 4
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Putative S-
- Pyruvate kinase
- Probable S-
- Transaldolase
Sequence:
MSSEKVLVGEYLFTRLLQLGIKSILGVPGDFNLALLDLIEKVGDETFRWVGNENELNGAYAADAYARVKGISAIVTTFGVGELSALNGFAGAYSERIPVVHIVGVPNTKAQATRPLLHHTLGNGDFKVFQRMSSELSADVAFLDSGDSAGRLIDNLLETCVRTSRPVYLAVPSDAGYFYTDASPLKTPLVFPVPENNKEIEHEVVSEILELIEKSKNPSILVDACVSRFHIQQETQDFIDATHFPTYVTPMGKTAINESSPYFDGVYIGSLTEPSIKERAESTDLLLIIGGLRSDFNSGTFTYATPASQTIEFHSDYTKIRSGVYEGISMKHLLPKLTAAIDKKSVQAKARPVHFEPPKAVAAEGYAEGTITHKWFWPTFASFLRESDVVTTETGTSNFGILDCIFPKGCQNLSQVLWGSIGWSVGAMFGATLGIKDSDAPHRRSILIVGDGSLHLTVQEISATIRNGLTPIIFVINNKGYTIERLIHGLHAVYNDINTEWDYQNLLKGYGAKNSRSYNIHSEKELLDLFKDEEFGKADVIQLVEVHMPVLDAPRVLIEQAKLTASLNKQ
Protein: Heat shock transcription factor (HSTF) (Heat shock factor protein) (HSF) (P22121)
Organism: Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Function: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular location: Nucleus {ECO:0000305|PubMed:1899375}.
Interaction partners:
- KLLA0C14322p
- Elongation factor 1-alpha
- KLLA0D12958p
- KLLA0D15103p
- Mitogen-activated protein kinase HOG1
- NAD-dependent histone deacetylase SIR2
- KLLA0D04818p
- Replication protein A subunit
- KLLA0C14652p
- non-chaperonin molecular chaperone ATPase
Sequence:
MGHNDSVETMDEISNPNNILLPHDGTGLDATGISGSQEPYGMVDVLNPDSLKDDSNVDEPLIEDIVNPSLDPEGVVSAEPSNEVGTPLLQQPISLDHVITRPASAGGVYSIGNSSTSSAAKLSDGDLTNATDPLLNNAHGHGQPSSESQSHSNGYHKQGQSQQPLLSLNKRKLLAKAHVDKHHSKKKLSTTRARPAFVNKLWSMVNDKSNEKFIHWSTSGESIVVPNRERFVQEVLPKYFKHSNFASFVRQLNMYGWHKVQDVKSGSMLSNNDSRWEFENENFKRGKEYLLENIVRQKSNTNILGGTTNAEVDIHILLNELETVKYNQLAIAEDLKRITKDNEMLWKENMMARERHQSQQQVLEKLLRFLSSVFGPNSAKTIGNGFQPDLIHELSDMQVNHMSNNNHNNTGNINPNAYHNETDDPMANVFGPLTPTDQGKVPLQDYKLRPRLLLKNRSMSSSSSSNLNQRQSPQNRIVGQSPPPQQQQQQQQQQGQPQGQQFSYPIQGGNQMMNQLGSPIGTQVGSPVGSQYGNQYGNQYSNQFGNQLQQQTSRPALHHGSNGEIRELTPSIVSSDSPDPAFFQDLQNNIDKQEESIQEIQDWITKLNPGPGEDGNTPIFPELNMPSYFANTGGSGQSEQPSDYGDSQIEELRNSRLHEPDRSFEEKNNGQKRRRAA
Protein: Nuclear hormone receptor family member nhr-31 (Q18192)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Vacuolar H ATPase
- Mediator of RNA polymerase II transcription subunit 11
Sequence:
MEQLDVEDWEYWGDEYLEEEPTYAIRPGTRVVKVERVPMMRGDLRTSGATSSSGPATSYIIRPSDKQPTVSSGGSQNGDSVCAVCGDGIAKLHYGVLACYGCKGFFRRTLTGKYRYACRFSNNCIVDKFQRNSCRYCRFQRCIQAGMDPKAVRPDRDQTGKQKVPRIKKKQIDEELLNHMMRLQGDDWSRKLPVETRILLMQLMSIEDKVVKGDNNMSAQNTAKDPKSISLREMFESKPALDGRRMEIGYEPFRMARTEELGVIAHRRAIAAVDWVDSLTEIADAVDTEDKVALVKSCYSPLTIFNFSARTAQNTKNPDILCLCSHSFVPRRLPPEFNETNHLSNFLIDRTLNELVAPLRKLNLKEEEIVPLKAIIILNPNAKGLSEHARHAISELRDKVQDMLFQIVKELHPIYSASSRFGNLLLLLPTITTLSGLMSENMHFCQALGGRASGDNLLAEMFGDRTFDDQLISSSISPPLFENPAEICLESISPPMSDRRFVRRVDVATQTNDDLLSSGPYLPHSNSCSSMLNAGYSPPMLSTSPFPLLDDNDSAFQNDISLTELNGCEEFFSQLMDQPIIDS
Protein: Serine/threonine protein kinase (Q5A650)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Carbon catabolite-derepressing protein kinase
- Serine/threonine protein kinase
- 5'-AMP-activated protein kinase subunit gamma
- Kis2p
- Kis1p
Sequence:
MSTSLSHQELSTEKGQSCPPIPDSNPLNPKSPALRTTSNSTILNSPIETINVNTSSKSNISGESTINGSAYSNSTTVVQPEVFGEAHTTTSTHNSASTRTERNEFPNSHLHQHQQESRNNGESNTPMTSPKHFPTDDLRHSLFYKAGSAAHHKSATSSKQSSTTSLKDGLNNANTYHFQNTFLDNNVMSDLEESPVPNERNPIQDTGLGPRSHATKFGVQSTTSLPTTISQSRLPNSNKSSFFPFKSYTSSPVKETKHVFLEYDPITRRKVLNTYEILREIGKGEHGKVKLARDLINNELVAIKIVNRKSRKERPSLRMRKNSSAPVINEYELKVKREIAIMKKCRHKHIVALREVLDDLNSLKIYLVLEYMEKGEIKWKKLQSDVAKPTANKCYDANDNEIPCCGNGRMQQRQQSLLTDEDLLSNEFSPNLTFKQSRKIFRDVLLGLEYLHMQGIVHRDIKPANLLVSADNIVKISDFGVSFATSLAENDEGYLVNELDLAKTAGTPAFFAPELCQFDDETATEKLSSSTESMAPPKIDYKIDIWALGVTLYCLLFGKVPFNADTEYDLFQVIVKEPLKFPNSIKAFNPPATVTEEEFELAKDLLSKMLDKNNRTRIEIQDIKEHPFTLMDLDNDVDGLHELFHLNGDNPVEPLSFDLDEHDIVSKDEVDNAVIGVGARIKRSLVRAIRAGGLKDGEIRNKFAALQLEHSRSENSEESSSGYSNYSSSTRLLGYQNGQNYSMILSEGLPVSSATPPPALLAAQQKRSSLLSPKSGGISEKNNPHFPSSLAHQIPNTSSPSTCSSSTSMAFQNHFSFAGMRESGKSLLHDMIESNSNNSSRRGSSAGITVSEAPQIETKRNVGGDLYLKNQSVVETFKGIQLQDDKRRRSSIFSLHSQIGTNSNKSSLSHELTPTQTGSGASTQQQHQHYSTNYSNIAAPIPVPAPRKQSTSDNEQDIKAPLLHQEKNVMGKPYLKIGPISIAREDEKSADDHPDSSIISLPLSESFASLDSINDDYLSRKYEEYTNNRKENSKSEGNVPVISLRRKSSLSESDLTRHVQLKDPFGKFKPDGSEIAEKFKAFNLGNLMKTGGKFALAEHNSSDSQQIKGNNYQSSDDGIAPKAIVPAISYSSSDSYSSCSSSSFDDEDESDDDEENLTLAFQSKVAPISRANFLSLTGRAKSHDSNLPTLRQNREKGRQLNPEFQGPIIFHDGLPEFEDVPDGLINSNPIGNNNVNGNSAFNSGYSYYDNVNPTVVSSNVSTATLTMGMAPSESVETNVEAPAQENAVKVSSPLNPHKNTSSRSDILKDLKKNTSISFGEILFNDQFNNHYKKDPVYSPFPSAKHLDNDQETIVKESASKFHEHRPTYYRSNSVTIGLLHRSTHREDDDDVSQTGNDLEQLITKEKQG
Protein: Probable LRR receptor-like serine/threonine-protein kinase At1g53430 (EC 2.7.11.1) (C0LGG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Probable LRR receptor-like serine/threonine-protein kinase At2g02780
- Probable LRR receptor-like serine/threonine-protein kinase At1g14390
- Ubiquitin fusion degradation UFD1 family protein
Sequence:
MGFIFSTEKVVYVLLLIFVCLENFGSNAQLLPEDEVQTLRTIFRKLQNQTVNIERTSCSDQNWNFVVESASNSPTSNITCDCTFNASSVCRVTNIQLKSFSLPGIFPPEFGNLTRLREIDLSRNFLNGTIPTTLSQIPLEILSVIGNRLSGPFPPQLGDITTLTDVNLETNLFTGPLPRNLGNLRSLKELLLSANNFTGQIPESLSNLKNLTEFRIDGNSLSGKIPDFIGNWTLLERLDLQGTSMEGPIPPSISNLTNLTELRITDLRGQAAFSFPDLRNLMKMKRLVLRNCLIRGPIPEYIGSMSELKTLDLSSNMLTGVIPDTFRNLDAFNFMFLNNNSLTGPVPQFIINSKENLDLSDNNFTQPPTLSCNQLDVNLISSYPSVTDNSVQWCLREGLPCPEDAKQSSLFINCGGSRLKIGKDTYTDDLNSRGQSTFSSVSERWGYSSSGVWLGKEDAGYLATDRFNLINGSTPEYYKTARLSPQSLKYYGLCLRRGSYKLQLHFAEIMFSNDQTFNSLGRRIFDIYVQGNLLERDFNIAERAGGVGKPFIRQIDGVQVNGSTLEIHLQWTGKGTNVIPTRGVYGPLISAITITPNFKVDTGKPLSNGAVAGIVIAACAVFGLLVLVILRLTGYLGGKEVDENEELRGLDLQTGSFTLKQIKRATNNFDPENKIGEGGFGPVYKGVLADGMTIAVKQLSSKSKQGNREFVTEIGMISALQHPNLVKLYGCCIEGKELLLVYEYLENNSLARALFGTEKQRLHLDWSTRNKICIGIAKGLAYLHEESRLKIVHRDIKATNVLLDLSLNAKISDFGLAKLNDDENTHISTRIAGTIGYMAPEYAMRGYLTDKADVYSFGVVCLEIVSGKSNTNYRPKEEFVYLLDWAYVLQEQGSLLELVDPDLGTSFSKKEAMRMLNIALLCTNPSPTLRPPMSSVVSMLEGKIKVQPPLVKREADPSGSAAMRFKALELLSQDSESQVSTYARNREQDISSSSMDGPWVDSSFSEPGKDVSLQQQEEGRSSSSSRKLLDDLTDVKIE
Protein: Salicylate synthetase, Irp9 (Q9X9I8)
Organism: Yersinia enterocolitica
Interaction partners:
Sequence:
MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYERPPCWYLGKGCQARLHINADGTQATFIDDAGEQKWAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHARGIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEASTTTQNAPLAVDTALNGEAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCLPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELTETREKLASIAPYLMV
Protein: Condensin complex subunit 3 (CAPG homolog) (p100) (Q10429)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.
Subcellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Interaction partners:
- Condensin complex subunit 1
- Condensin complex subunit 2
- Structural maintenance of chromosomes protein 4
- Structural maintenance of chromosomes protein 2
- Structural maintenance of chromosomes protein 1
- Structural maintenance of chromosomes protein 3
- Kinesin-like protein cut7
- Kinetochore protein ndc80
- Kinetochore protein nuf2
- Anaphase spindle elongation protein 1
Sequence:
MSCIQIISSSQTSIAGHRKLCNKLFTLRTQEGFETDILRALNIILTVKKGNSNADRVLRFLVTFVNYLQQKDPEIDIVQPILKHILRGLDAKDKTVRYRCCQIIARVVNCVKEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEENDVRNILLFLLQNDPSSEVRRSVLLNIEVSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLARTFNEICIEKNYTDLLDKMPEVVQLTYYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEIITEVFEQGHSQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNENLYMVDMLKTLIIPAVRSHDLPIREKGLECLSLVCLLNADLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGKAKFTEYEDAISSILFEALGEFENAELQTLGAEAIAKLLVILHYRDELFLKPLIIQYFEPNTVDNHALRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHNVHLHLANMIFESLPNASEGKERKFMISLLGKLKIPTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQNEEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEEDL
Protein: Activin A subunit (Q91752)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
Sequence:
MPAHLLKGVCLVLCWIIVRSSPTPGSEGHSSVNDCPSCALAKFQKDVPSSQSDMVEAVKKHILNMLHLRDRPNITQTVPKAALLIAIKKLHVGKVGDDGQVQIEDVIAGRAEMNEISEQTSEIITFAESGEFLRH
Protein: UDP-glycosyltransferase 75C1 (EC 2.4.1.-) (Anthocyanin 5-O-glucosyltransferase) (UDP glucose:anthocyanin 5-O-glucosyltransferase) (Q0WW21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the glycosylation of anthocyanins from UDP-glucose.
Interaction partners:
- Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase
- Malonyl-CoA:anthocyanidin 5-O-glucoside-6''-O-malonyltransferase
- Coumaroyl-CoA:anthocyanidin 3-O-glucoside-6''-O-coumaroyltransferase 2
- Dihydroflavonol 4-reductase
- Glutathione S-transferase F12
- Transcription factor MYB75
- Flavonoid 3'-monooxygenase
- Leucoanthocyanidin dioxygenase
- Coumaroyl-CoA:anthocyanidin 3-O-glucoside-6''-O-coumaroyltransferase 1
- Naringenin,2-oxoglutarate 3-dioxygenase
Sequence:
MATSVNGSHRRPHYLLVTFPAQGHINPALQLANRLIHHGATVTYSTAVSAHRRMGEPPSTKGLSFAWFTDGFDDGLKSFEDQKIYMSELKRCGSNALRDIIKANLDATTETEPITGVIYSVLVPWVSTVAREFHLPTTLLWIEPATVLDIYYYYFNTSYKHLFDVEPIKLPKLPLITTGDLPSFLQPSKALPSALVTLREHIEALETESNPKILVNTFSALEHDALTSVEKLKMIPIGPLVSSSEGKTDLFKSSDEDYTKWLDSKLERSVIYISLGTHADDLPEKHMEALTHGVLATNRPFLWIVREKNPEEKKKNRFLELIRGSDRGLVVGWCSQTAVLAHCAVGCFVTHCGWNSTLESLESGVPVVAFPQFADQCTTAKLVEDTWRIGVKVKVGEEGDVDGEEIRRCLEKVMSGGEEAEEMRENAEKWKAMAVDAAAEGGPSDLNLKGFVDEDE
Protein: Protein edg-1 (Enlarged deps-1 granule 1) (Q17436)
Organism: Caenorhabditis elegans
Function: Plays a role in regulating deps-1 cluster formation in the germline.
Subcellular location: Cytoplasmic granule {ECO:0000305|PubMed:32843637}.
Interaction partners:
- P-granule-associated protein deps-1
- MUTator
Sequence:
MVENKSSYELPDQKTLDMNKEWVQELEDIFYSYKKYDVNKVRVQQFLDRRSDFLVYDFYTSNLSMDAMQYFQAGVTQKDVGLSKDYILLMRKLYSMLTEPSKQFFQEQFVKEWQYHEIDYTPYFETLVPRFREKIARLLDEIVKNPEEVDDDVQEELRWHLLFSPVTTLLDIFTRCLKNFEITGFCLNVCLKVPQLFFDRPLKIYHTEYETDRVESLMALVFRRLIFNKRWVDTSDEEWSNLEQLARVICSGQEPSLMSAWPLLEVVLCELYTQNRTPMISVEVLSEIAVKIVENFDNLKYATSARTKPAENVLLTPSIICFLLNIIVDENVSNTVIENCKMILKAIGQNMEQPFDAEAKSYLTSKVLKEFPWTLEFAISTWFKALEVEKRRIPSAVYKAINAEMKETFDERTFDIEESETVDQSINEEDEERCSTLSSESSVKTAISIDHKSDTAVDNLEMNQLHLSPKPKASVEAVKSCKPAFVAVIFEEIPPETDQNISVFEDPTIEVLTEYLDCIITMGVFDISCADELMRHSSVTFESSEQLEKVMKTAFEENFEIANAGPQRIKEISGKILEVFGSTSSESDHDRIASSIIELIPTEEYEKTGPRWSHDIKKSEIIQPLVIPVEATLESWPPAEYRYVAPGIKESRDSARHERLLRQQLATTKSLEMAQLHRDLWAENEKNMEHWTRPASPCNSSFFAESSVKPTTSSAYGNSSNFSRYAD
Protein: Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] (Q99JB6)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18368049}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZS1}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. {ECO:0000250|UniProtKB:Q9BZS1, ECO:0000269|PubMed:19117830}.
Interaction partners:
- Runt-related transcription factor 1
- Histone acetyltransferase KAT5
- Signal transducer and activator of transcription 3
- Nuclear receptor ROR-gamma
- Hypoxia-inducible factor 1-alpha
- Nuclear factor of activated T-cells, cytoplasmic 2
- Interleukin-2
- Interleukin-2 receptor subunit alpha
- T-cell surface glycoprotein CD4
- Histone deacetylase 7
Sequence:
MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP
Protein: Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A) (Q96BI1)
Organism: Homo sapiens (Human)
Function: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Subcellular location: Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000269|PubMed:9744804}.
Interaction partners:
- Pleckstrin homology-like domain family A member 2
- Uncharacterized protein SLC67A1-AS
- Cyclin-dependent kinase inhibitor 1C
- E3 ubiquitin-protein ligase RNF167
- Potassium voltage-gated channel subfamily KQT member 1
- U5 small nuclear ribonucleoprotein TSSC4
- Achaete-scute homolog 2
- Insulin-like growth factor 2
- Oxysterol-binding protein-related protein 5
Sequence:
MQGARAPRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRKDKVR