wanglab/gogpt-training-data huggingface dataset:
Protein: Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7) (Q9UI95)
Organism: Homo sapiens (Human)
Function: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19753112}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19753112, ECO:0000269|PubMed:21063390}. Cytoplasm {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17719540}. Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}.
Interaction partners:
- DNA repair protein REV1
- DNA polymerase delta subunit 2
- DNA polymerase zeta catalytic subunit
- Shieldin complex subunit 2
- DNA polymerase delta subunit 3
- Shieldin complex subunit 3
- Shieldin complex subunit 1
- Pachytene checkpoint protein 2 homolog
- DNA polymerase delta catalytic subunit
- Mitotic spindle assembly checkpoint protein MAD2A
Sequence:
MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKGS
Protein: Uncharacterized protein Rv2917 (P9WL21)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved alanine and arginine rich protein
- ATP-dependent helicase DinG
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- DNA polymerase I
- 5'-3' exonuclease
- DUF3097 domain-containing protein
- DNA-directed RNA polymerase subunit beta'
- ERCC4 domain-containing protein
Sequence:
MLHFTAATSRFRLGRERANSVRSDGGWGVLQPVSATFNPPLRGWQRRALVQYLGTQPRDFLAVATPGSGKTSFALRIAAELLRYHTVEQVTVVVPTEHLKVQWAHAAAAHGLSLDPKFANSNPQTSPEYHGVMVTYAQVASHPTLHRVRTEARKTLVVFDEIHHGGDAKTWGDAIREAFGDATRRLALTGTPFRSDDSPIPFVSYQPDADGVLRSQADHTYGYAEALADGVVRPVVFLAYSGQARWRDSAGEEYEARLGEPLSAEQTARAWRTALDPEGEWMPAVITAADRRLRQLRAHVPDAGGMIIASDRTTARAYARLLTTMTAEEPTVVLSDDPGSSARITEFAQGTSRWLVAVRMVSEGVDVPRLSVGVYATNASTPLFFAQAIGRFVRSRRPGETASIFVPSVPNLLQLASALEVQRNHVLGRPHRESAHDPLDGDPATRTQTERGGAERGFTALGADAELDQVIFDGSSFGTATPTGSDEEADYLGIPGLLDAEQMRALLHRRQDEQLRKRAQLQKGATQPATSGASASVHGQLRDLRRELHTLVSIAHHRTGKPHGWIHDERRRRCGGPPIAAATRAQIKARIDALRQLNSERS
Protein: Surfeit locus protein 4 (Q5T8U5)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004457}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}.
Interaction partners:
Sequence:
MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSQPSQQ
Protein: ADP-glucose pyrophosphorylase family protein (At1g74910/F9E10_24) (Putative GDP-mannose pyrophosphorylase; 64911-67597) (Q9C9P3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mannose-1-phosphate guanylyltransferase 1
- Phosphomannomutase
- ADP-glucose pyrophosphorylase family protein
- GDP-mannose 4,6 dehydratase 1
- GDP-mannose 3,5-epimerase
- GDP-mannose 4,6 dehydratase 2
- Nudix hydrolase 14, chloroplastic
- Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase
- Mannose-6-phosphate isomerase 1
- Dolichol-phosphate mannosyltransferase subunit 1
Sequence:
MGSSMEEKVVAVIMVGGPTKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPNLAQIYLVGFYEEREFALYVSAISNELKVPVRYLREDKPHGSAGGLYHFRNLIMEDSPSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVSPESASQFGELVADPVTNELLHYTEKPETFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKRVSSFEALQPATRIPTDFVRLDQDILSPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQFRLTSPQLLASGDGTRSAIVIGDVYIHPSAKVHPTAKIGPNVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQAEGVYNSKLGVTILGDSVAVEDEVVVTSSIVLPNKTLNVSVQDEIIL
Protein: Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) (Q6WRI0)
Organism: Homo sapiens (Human)
Function: Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:27137492}.
Interaction partners:
Sequence:
MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVMQIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI
Protein: sn-1-specific diacylglycerol lipase (EC 3.1.1.116) (Q86B55)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVKLLFYHLIGYLLILFFSICVEIGICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTAPIDDPKKVYIAIIICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSMNRNWRQRKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVLLRKFQRLEREAIVRQRKNGTYEFLSGVPITERTQFLALNDAKNYDFFQTVIHYMYFAQGAYGWPMYVIINRSKMWHLVPELKCFGCCCGTSDDTEVIQDNCCLCNYAALKKTLQLGDIDIVYATYHVDVGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMVQAAIYIRNKLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYSPPGGLLSMPAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTISCSVICCGCGPEPTSVVNMSGQDTHINQYQEERGTARSTSAHPTDSSIALTLHQPLYPPGRIIHIVRHHPKPDEQKYDSGWRNVLKNREPVYQAIWADSTDFDEVLISPVMLQDHMPDKVLAALKKVVSCRDRTVKACTTRRRNDNTTITTTTTVTTTTTTTQNTDTRYSRPPSI
Protein: HTH-type transcriptional repressor AcnR (TetR-type regulator AcnR) (Q8NQ97)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: AcnR negatively controls the expression of the aconitase gene acn. Binds to the imperfect inverted repeat in the acn promoter region.
Interaction partners:
- Hypothetical membrane protein
- GMP synthase-Glutamine amidotransferase domain
- Hypothetical membrane protein
Sequence:
MSVAAGDKPTNSRQEILEGARRCFAEHGYEGATVRRLEEATGKSRGAIFHHFGDKENLFLALAREDAARMAEVVSENGLVEVMRGMLEDPERYDWMSVRLEISKQLRTDPVFRAKWIDHQSVLDEAVRVRLSRNVDKGQMRTDVPIEVLHTFLETVLDGFISRLATGASTEGLSEVLDLVEGTVRKRD
Protein: Sorbitol dehydrogenase (SDH) (XDH) (EC 1.1.1.14) (EC 1.1.1.9) (L-iditol 2-dehydrogenase) (Polyol dehydrogenase) (Xylitol dehydrogenase) (W5QIT0)
Organism: Ovis aries (Sheep)
Subcellular location: Mitochondrion membrane {ECO:0000256|RuleBase:RU369026}; Peripheral membrane protein {ECO:0000256|RuleBase:RU369026}. Cell projection, cilium, flagellum {ECO:0000256|RuleBase:RU369026}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000256|RuleBase:RU369026}.
Interaction partners:
Sequence:
MAAAKPENLSLVVHGPGDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKKPMVLGHEASGTVVKVGSLVRHLQPGDRVAIEPGAPRETDEFCKIGRYNLSPTIFFCATPPDDGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLAAKAMGAAQVVVTAVDLSASRLSKAKEVGADFILQISNESPQEIAKKVEGLLGSKPEVTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMIKCDPSDQNP
Protein: N(6)-adenosine-methyltransferase MT-A70-like (EC 2.1.1.348) (Protein EMBRYO DEFECTIVE 1706) (Protein METTL3 homolog) (O82486)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTB, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
Subcellular location: Nucleus {ECO:0000269|PubMed:19245862}.
Interaction partners:
- N6-adenosine-methyltransferase non-catalytic subunit MTB
- FKBP12-interacting protein of 37 kDa
- Protein virilizer homolog
- E3 ubiquitin-protein ligase HAKAI homolog
- RNA demethylase ALKBH10B
- YTH domain-containing protein ECT3
- YTH domain-containing protein ECT4
- YTH domain-containing protein ECT2
- RNA demethylase ALKBH9B
- Nuclear cap-binding protein subunit 2
Sequence:
METESDDATITVVKDMRVRLENRIRTQHDAHLDLLSSLQSIVPDIVPSLDLSLKLISSFTNRPFVATPPLPEPKVEKKHHPIVKLGTQLQQLHGHDSKSMLVDSNQRDAEADGSSGSPMALVRAMVAECLLQRVPFSPTDSSTVLRKLENDQNARPAEKAALRDLGGECGPILAVETALKSMAEENGSVELEEFEVSGKPRIMVLAIDRTRLLKELPESFQGNNESNRVVETPNSIENATVSGGGFGVSGSGNFPRPEMWGGDPNMGFRPMMNAPRGMQMMGMHHPMGIMGRPPPFPLPLPLPVPSNQKLRSEEEDLKDVEALLSKKSFKEKQQSRTGEELLDLIHRPTAKEAATAAKFKSKGGSQVKYYCRYLTKEDCRLQSGSHIACNKRHFRRLIASHTDVSLGDCSFLDTCRHMKTCKYVHYELDMADAMMAGPDKALKPLRADYCSEAELGEAQWINCDIRSFRMDILGTFGVVMADPPWDIHMELPYGTMADDEMRTLNVPSLQTDGLIFLWVTGRAMELGRECLELWGYKRVEEIIWVKTNQLQRIIRTGRTGHWLNHSKEHCLVGIKGNPEVNRNIDTDVIVAEVRETSRKPDEMYAMLERIMPRARKLELFARMHNAHAGWLSLGNQLNGVRLINEGLRARFKASYPEIDVQPPSPPRASAMETDNEPMAIDSITA
Protein: Sugar transport protein 10 (AtSTP10) (D-glucose-H(+) symport protein STP10) (D-glucose-proton symporter STP10) (Hexose transporter 10) (Q9LT15)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hexose-H(+) symporter that catalyzes the high-affinity uptake of glucose, galactose and mannose. Proton-coupled symporter responsible for the uptake of glucose from the apoplast into the cells (Probable).
Subcellular location: Membrane {ECO:0000269|PubMed:26893494}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane. {ECO:0000269|PubMed:26893494}.
Interaction partners:
- At2g39500/F12L6.16
- UDP-galactose/UDP-glucose transporter 2
- CMP-sialic acid transporter 3
Sequence:
MAGGAFVSEGGGGGRSYEGGVTAFVIMTCIVAAMGGLLFGYDLGISGGVTSMEEFLTKFFPQVESQMKKAKHDTAYCKFDNQMLQLFTSSLYLAALVASFMASVITRKHGRKVSMFIGGLAFLIGALFNAFAVNVSMLIIGRLLLGVGVGFANQSTPVYLSEMAPAKIRGALNIGFQMAITIGILVANLINYGTSKMAQHGWRVSLGLAAVPAVVMVIGSFILPDTPNSMLERGKNEEAKQMLKKIRGADNVDHEFQDLIDAVEAAKKVENPWKNIMESKYRPALIFCSAIPFFQQITGINVIMFYAPVLFKTLGFGDDAALMSAVITGVVNMLSTFVSIYAVDRYGRRLLFLEGGIQMFICQLLVGSFIGARFGTSGTGTLTPATADWILAFICVYVAGFAWSWGPLGWLVPSEICPLEIRPAGQAINVSVNMFFTFLIGQFFLTMLCHMKFGLFYFFASMVAIMTVFIYFLLPETKGVPIEEMGRVWKQHWFWKKYIPEDAIIGGHDDNNTN
Protein: BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21) (Q4G0X4)
Organism: Homo sapiens (Human)
Function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB).
Interaction partners:
- Probable transmembrane reductase CYB561D1
Sequence:
MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR
Protein: Malate dehydrogenase (EC 1.1.1.37) (P61889)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible oxidation of malate to oxaloacetate.
Interaction partners:
- Fumarate hydratase class II
- Fumarate hydratase class I, aerobic
- Citrate synthase
- Isocitrate dehydrogenase
- Fumarate hydratase class I, anaerobic
- NADP-dependent malic enzyme
- Phosphoenolpyruvate carboxylase
- Aspartate aminotransferase
- Glyceraldehyde-3-phosphate dehydrogenase A
- Phosphoenolpyruvate carboxykinase
Sequence:
MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGEEFVNK
Protein: Probable serine/threonine-protein kinase ifkB (EC 2.7.11.1) (Initiation factor kinase B) (Q550L8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
- Probable histidine--tRNA ligase, mitochondrial
- Probable basic-leucine zipper transcription factor R
Sequence:
MIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLLPSKMEDDILKEAIKTIANPTISLFSYLMEKLFCLSNDEHIMSRYLYTSNPSLTPMHLICREKTFSRLEKIFLNHGSIRIDTPTLFPKNPTNSTHPGAANVAKFLDESGTVVYLPYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKELYECDFDIIGPSKSRHISDAETLRIIIEIMEEFKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSILSECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKEHGLSASIVSNISTYFRQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYYEGLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIVSGVGVTLACEKIVNSVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFVCSLGSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSRKHNVDSKNIIQNTSSSDLSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSNQSTSSSGNSNNSNTQQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSSSNIIHFDEPTDSFSTQIVYQGVEEIKKSKIETLVQTSLSKLFRGFIQSKSSTIRVIVTDLAYSVIRDLQISESHDNISKFQRVSKEKLLQLKNQIFKWKVYPFIVIHSIKDDKSVIFNSVV
Protein: Transient receptor potential cation channel, subfamily C, member 7 (A0A8I6ATX7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
KRTSAPCREERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNLQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSVFVASFTARFMAFLKASEAQLYVDQYVQDVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKRCENDLEMGMLNSKFRKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (F1Q6T9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
Interaction partners:
Sequence:
MPLPFGLKLKRTRRYTVSSKSCLVTRIQLLNGEYVEFTLSVESTGQECLEAVAQRLELREITYFSLWYYNKQNQQRWIDLEKPLKKQLDKYGLEPTVYFGVVFYVCTVTQLQQEITRYQYYLQLKKDVLEGKIPCSIEQAIHLASLAVQADLGDFNRYDSQEFLQKIVLFPMPWIQDERVVEEATQKVTMLYQNYRGLSAPEAELLYMQEVEKIEGYGEESIQAKDSQATDVIIGSCLDGIFVKHKNGKAPLIFRWNDINNMTHNKSFFALELANKEDTIQFQTEDMETSKYVCRMWLARHKFYKINNSSLQTQPAPVNPVRRRSSTRMSLPKPQPYMMPPQMHFNGHYNEPYTSSQDNLYINNQNGFYYHSQTSLDRSPHEYNGRIRNGSVYSAQSTSSLNNPQHYLQPSPMSSNPSITGSDLMRPDYVPSHRHSALIPPSYRATPDYETVMRQKNMIPAAERQSHSMRNLNIGNSYAYSRPDPLVYSQPEIREHGAGQYPFHLNYSFHSPSPYPYPTERRPVVGAVSVPELTNVQLQQAQEYPPPNIIRNQVYWPPPPYPYPHPRPANSTPDLSRHLYVSSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLVTARRPHMHKRNSIEIAGLAYGLENMRLKERKVSASAADTPPPVAAAVPHAASGSDINVVLEVSKPEDVGIKEDVFYGHKKSLSDATMLVHSSGEEEEFEDDSGRHTPQSQDAVSGPEHPMTSLGRSLGDPPAYPFSHSMETVLTSPPAYQAHSIMQKAEDVGPLPPLREPGLMMPSVSEGDLSGRLRKNRDISKRPVSDVPPGRRNIDGLPPAGMKKGRSEVKKVGPLKLAALNGLTLSRIPLPDDGKDDPESASNDERCKFLEQRLDQGMVFTEYEQVPKKRPNSEYSIAQMPENNDRNRFQDVLPYDDTRVELVPTKENNTGYINASHIRVTVRGKEWSYIASQGPLSSTCQDFWQMVWEQGVSIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKIKHLLTGQERTVWHLQYTDWPDHGCPEDFKGFLSYLEEIQSVRRHTNSSSDPKNTNLPVLVHCSAGVGRTGVVILSEIMIACLEHNEMLDVPTVLNLLRQQRMMMVQTLSQYTFIYKVLIQFLKNSRLI
Protein: DnaJ protein ERDJ2B (Chaperone protein dnaJ 29) (AtDjC29) (AtJ29) (Endoplasmic reticulum dnaJ domain-containing protein 2B) (AtERdj2B) (Translocation protein SEC63 homolog ERDJ2B) (F4JIN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:18718935}; Multi-pass membrane protein {ECO:0000305|PubMed:18718935}.
Interaction partners:
- Protein STABILIZED1
- Translocation protein SEC62
- Pre-mRNA-processing-splicing factor 8A
- Pre-mRNA-processing-splicing factor 8B
- Small nuclear ribonucleoprotein Sm D2
- DnaJ protein ERDJ2A
- 109 kDa U5 small nuclear ribonucleoprotein component GFL
- 110 kDa U5 small nuclear ribonucleoprotein component CLO
- Nuclear protein-like
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7
Sequence:
MAESEENSVLFPIFILTMMAIPLVPYTFVKLSRAFSKKQRSIHCQCLECDRSGKYKRSISQSISSFTSCSNLTVVLLWIVMIFLIYHTKNMSRESQLFEPFGILGLEPGASDSEIKKAYRRLSIQYHPDKNPDPEANKYFVESIAKAYQALTDPLSRENFEKYGHPDGRQGYTMGIALPQFILNMNGESGGILLLCTVGLCILLPLVIASIYLWRSSKYTGNHVKLQTRQAYFELLQPSLTPSKVMDIFIRAAEYAEISVRKSDDESLQKLFMSVKSELNLDPKKLKQEEAKFWKKHPATIKTELLIQKQLTRESSVLSPTLQRDFRHVLEFAPRLLEDLIKMAVIPRNEQGRGWLRPALGVMELSQCIVQAVPLSARKSSSEDIAPFLQLPHFNESIAKSIALQVKSFQKFQELSLAERSKLLREVVSLSETDVQDIEKVLEMIPSLKINVTCKTEGEEGIQEGDIMTVQAWITLKRPNGLIGAIPHSPYFPFHKEENFWVLLADSNHVWFFQKVKFMDEAGAIAAASNTITETMEPLGASVKETNDAVKEAVEKVKSGSRLVMGRLLAPGEGTYNLTCFCLSDTWIGCDQKTSLKVEVLKRTRDVEGENAEEGLEEEDDEIEEEDYESEYSEDEEDKKRGSKKKVNKESSSEESGSDEE
Protein: Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (Q9R1W5)
Organism: Mus musculus (Mouse)
Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q16602}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16602}.
Interaction partners:
- Receptor activity-modifying protein 1
- Receptor activity-modifying protein 2
- Pro-adrenomedullin
- Receptor activity-modifying protein 3
- Calcitonin
- Calcitonin gene-related peptide 2
- Islet amyloid polypeptide
- Protein ADM2
- DNA-directed RNA polymerase III subunit RPC9
- Calcitonin receptor
Sequence:
MDKKHILCFLVLLPLNMALISAESEEGVNQTDLGVTRNKIMTAQYECYQKIMQDPIQQAEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQVESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHFQGLLVATIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDMQGYSHDCPTEHLNGKSIQDIENVALKSENMYDLVM