Protein: Merozoite surface protein 1 (PfMSP-1) (Merozoite surface antigen) (PMMSA) [Cleaved into: p83 subunit; p30 subunit; p38 subunit; p42 subunit; p33 subunit; p19 subunit] (Q8I0U8)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cell membrane {ECO:0000269|PubMed:20735778, ECO:0000269|PubMed:21175202, ECO:0000269|PubMed:26468747}; Lipid-anchor, GPI-anchor {ECO:0000255}. Secreted {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931, ECO:0000269|PubMed:16322767, ECO:0000269|PubMed:17097159, ECO:0000269|PubMed:21175202, ECO:0000269|PubMed:25074930, ECO:0000269|PubMed:29511044}.; SUBCELLULAR LOCATION: [p19 subunit]: Cell membrane {ECO:0000269|PubMed:1694225, ECO:0000269|PubMed:18769730}; Lipid-anchor, GPI-anchor {ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:18769730}; Lipid-anchor, GPI-anchor {ECO:0000255}. Note=In free merozoites, localizes to the cell membrane (PubMed:1694225, PubMed:18769730). Following merozoite invasion of host erythrocytes, p19 subunit is endocytosed into small food vacuoles in the ring stage and persists throughout the subsequent intra-erythrocytic stages at the surface of the food vacuole where it forms clusters (PubMed:18769730). {ECO:0000269|PubMed:1694225, ECO:0000269|PubMed:18769730}.
Interaction partners:
- Merozoite surface protein 2
- Merozoite surface protein 3
- Merozoite surface protein 6
- Merozoite surface protein 8
- Merozoite surface protein 4
- Gametocyte-specific protein
- Merozoite surface protein 5
- Erythrocyte binding antigen-175
- Exported serine/threonine protein kinase
- Uncharacterized protein
Sequence:
MKIIFFLCSFLFFIINTQCVTHESYQELVKKLEALEDAVLTGYSLFQKEKMVLNEEEITTKGASAQSGASAQSGASAQSGASAQSGASAQSGASAQSGTSGPSGPSGTSPSSRSNTLPRSNTSSGASPPADASDSDAKSYADLKHRVRNYLFTIKELKYPELFDLTNHMLTLCDNIHGFKYLIDGYEEINELLYKLNFYFDLLRAKLNDVCANDYCQIPFNLKIRANELDVLKKLVFGYRKPLDNIKDNVGKMEDYIKKNKTTIANINELIEGSKKTIDQNKNADNEEGKKKLYQAQYDLSIYNKQLEEAHNLISVLEKRIDTLKKNENIKKLLDKINEIKNPPPANSGNTPNTLLDKNKKIEEHEEKIKEIAKTIKFNIDSLFTDPLELEYYLREKNKKVDVTPKSQDPTKSVQIPKVPYPNGIVYPLPLTDIHNSLAADNDKNSYGDLMNPHTKEKINEKIITDNKERKIFINNIKKKIDLEEKNINHTKEQNKKLLEDYEKSKKDYEELLEKFYEMKFNNNFNKDVVDKIFSARYTYNVEKQRYNNKFSSSNNSVYNVQKLKKALSYLEDYSLRKGISEKDFNHYYTLKTGLEADIKKLTEEIKSSENKILEKNFKGLTHSANGSLEVSDIVKLQVQKVLLIKKIEDLRKIELFLKNAQLKDSIHVPNIYKPQNKPEPYYLIVLKKEVDKLKEFIPKVKDMLKKEQAVLSSITQPLVAASETTEDGGHSTHTLSQSGETEVTEETEETEETVGHTTTVTITLPPTQPSPPKEVKVVENSIEHKSNDNSQALTKTVYLKKLDEFLTKSYICHKYILVSNSSMDQKLLEVYNLTPEEENELKSCDPLDLLFNIQNNIPAMYSLYDSMNNDLQHLFFELYQKEMIYYLHKLKEENHIKKLLEEQKQITGTSSTSSPGNTTVNTAQSATHSNSQNQQSNASSTNTQNGVAVSSGPAVVEESHDPLTVLSISNDLKGIVSLLNLGNKTKVPNPLTISTTEMEKFYENILKNNDTYFNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLPEAKVTTVVTPPQPDVTPSPLSVRVSGSSGSTKEETQIPTSGSLLTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDEYLDQVVTGEAISVTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEKFPSSPPTTPPSPAKTDEQKKESKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAHVKITKLSDLKAIDDKIDLFKNPYDFEAIKKLINDDTKKDMLGKLLSTGLVQNFPNTIISKLIEGKFQDMLNISQHQCVKKQCPENSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADATCTEEDSGSSRKKITCECTKPDSYPLFDGIFCSSSNFLGISFLLILMLILYSFI