wanglab/gogpt-training-data huggingface dataset:
Protein: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A) (Q9HCR9)
Organism: Homo sapiens (Human)
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
Interaction partners:
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Adenine phosphoribosyltransferase
- GMP reductase 1
- Guanylate kinase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Deoxycytidine kinase
- Inosine triphosphate pyrophosphatase
Sequence:
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Protein: GRIP domain-containing protein (D0Z5P0)
Organism: Caenorhabditis elegans
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
- Intraflagellar transport protein 20 homolog
- I-beta-1,3-N-acetylglucosaminyltransferase
- Ubiquitin-conjugating enzyme E2 variant 3
Sequence:
MSGWLRNIQGQLTDLANEVLNEANDVLAEATEEVQDPDGEIIVAKKKAAEAEKQLAIETSRVELLGNEKSHLEQQLYDAHVEMDAIGAKFNGMVKQRDDEIKKLKTQMEQLQESGWNESTSDIDQICELKKQVSHWKSLAEEKSGDGGGGGEKEEEEMIKLSELEKRIEALRQQKEHEIQSLVESHAENVLEMREMYEEKIAAMQVLPYNASSSTSNADALDAVMLEREDLLLLQHQKSTNGSDGGDGERPVVVDLGSHDELVDERIRQMEVELQRCRDEKMECQHNSDAQIEDLKTQNKELANAYTELNEEFEGFKEQHTATQNANNDLNRRIDSLKANLIEYEERYEICKKESAETASQLIKLTNDFARLKTGVDSVSQRREDCDTMVNEEVDKLRASLEETRQDREHLRSDVQKFQVAVGEIDVELDKLREANRLLLGENVALQENLANYEDTMKSLISSSEQDIGKFREQFGEIQENHKQQREAMIAENDALREESAAIKRQRDIVLEESALLKEVNEKLKQKSATEESKIELLQKKADLLEQVLEEERANHQREKDEAVEQKKNNLESQIQCDADDDDENSTEEQKLNNEIKILKLQLREALDANTEKTEECEKLHIETRNLEREVDLRQNCVDEMIAQTNTLQMQQESMSTAMKTLQKQILANEREICQLEEKLTESELKTQRSEEKVKNLEDFIVGERMEEAEAEAEAAADGGGARNEVSHLKRYIADLQSKLSTMEEELKVLREQKLDENNEATQVRQMLERDLFEAEEVDRGLLEGIENRVKEMEDQLEAKVKALKEAKEESSKLEKKLEKAEKERIALEVLEEQNRFLNEKLEKLMEKENSDQTGASQATAELQNSSISQLTEQLESVKAENARLASEIEKSGLSENSDELRALQLENEQLKLSQSTSSTEELRAAIAVLQQENEHLKGVAKTQYEESVKYYEQFQAMVTHNQQMSDQMEQVQRQTTVIQGTMAAENEAHEKKVKELQRLREHLMIVEETSTREAVEAEQRETELRARVRELETKGHQVEEGASESTQQYQVQIASLTSQVESLQNKTTEWKKKFETEVSARQQTQEALTSLQNVVRELSIDHEKDSAFASHRNLELQTMIGTLNEEIAQIREDLDRQSLGKQASEEESERRQLQLDSKQKIIEDLEVQIEELRSPKKPTESYRIDDSTLRQLFLSYFVSDAAKRPDIALLLANVLEYPAEEMDKFKSAVRQSFGQQQQQQSSSFFFGSARSTPPPNGPTIADQFVRFLEAESESSRTAPHLPIRSQQQPSTPGLSLESPRQKSPNPQNSSQTASASSSAAALDSILR
Protein: Dihydroorotate dehydrogenase (quinone) (I3L449)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEESRALAESQMPLEQIIGGEDSV
Protein: A-kinase interacting protein 1 (H0YCH8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
AAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLEKQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLVFPV
Protein: Fgr32p (A0A1D8PTM6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Clathrin heavy chain
- ADP-ribosylation factor
- ADP-ribosylation factor
- SNAP receptor
- Heat shock protein homolog SSE1
- Oxysterol-binding protein related protein
- Endoplasmic reticulum chaperone BIP
- Clathrin light chain
- Fus1p
- Heat shock protein HSP70
Sequence:
MVPPKKDAFADLFQSASSGNSTSSLNLKLNNLSLSERQKLQQQQQQQQRQQAFQQPTKNNLLQSQSQNNSVNSSWSNIDILTPSRTASPVSNSGNSESGVSLHQTGILSAQPEDPFSIFLESKSQNSSSKSDPTPVNRDNSKSAEISLLDDDFTDFFQESKSASKSVASPSISSQTSEAESHSTVSHSKRASNRANEQKDFVVAELVDIGFSVEDANEAINKRGLDLQKCVNYIMSKNSGNSNTDMVENGGSVLGQRSEGIKLNELGTDLVKKANSFYNFSKRAVMQNLEQFSGPRSNNDNIPAWMKTKEKYESDAMEKKYGGEEYGTDEENINQKDIERFMKQQRERNRDRSRARFENWIDGKPKQSHPSSKESSPELPQRPSNSNRHGIMSSQKREPPRRNVQQKASIELPQRPARKSQVTAPPERPTSINHHASDPVSVDSSVNSTTPDEDLLGLGTSGTSNGRNAPAPGSFRDSSPLNQFVYTDYTTAKEKATAAYKSGDYTTALESYTICLGCLPPNHELRIVILSNLASVNKLSGHLKESLDNIKDAEALFLPQEILSDYEIADKSIKYWCTKLFMIKAEVLELLEKYSEALEQYLVLIRQLNCNDKKVMDGKRRVDKIVNPQNYKPPKPSVSSRASTPSNKTPAVETKRPTKSGDDEVDALTKDKIEDKIRSWADAKQNNLRAMLTNLNEIIPPNIRMSEKLRNLTTNDLMLPKQVKIQYMKVISSIHPDKLASQTKDNRESGLICNGVFITLNKRWEAFKQEENI
Protein: Interferon regulatory factor 7 (F9UKU0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MQSCKPQFADWLIEQVRTEQYTGLFFIDNNKFRVPWKHNSRKDCSEDDRKIFRAWAVVSGKINEHPTDKAKWKTNFRSALNSLCRRFKMVEDHSKDSNDPHKVYLVINEYNYESPHREEITLENYGLDCALIPTENTPPGMEHDILNFSNLTLNPLDLNQHTENSIPVHTHHPVPPVLVQQPYYQVNPDALLNLPAAHSSLWDLEITISYRGSEMRKTQVSGPRVQLHYQCNALEPNTQPLCFPSTDGLPDHKQIEYTNCILGSVQRGLLLEVQNTGIYGYRQDKCHVFSSTSDPREAHPEPRKMPQNEMVQLLSFQQYENELIAFKENRRGSPDYTIHMCFGEKFPDGKPLEKKLIIVKVVPLICRYFHEVAQEEGASSLQNDISLQISHHNSLMELINATWPDGPQHAMGQYF
Protein: Protein kinase, putative (Q389P3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHNVPLLAWRYEHVAVVGKGGFGIVSEHVDRFTGEHVAVKTIPSRFVNQESARLVREIDIMSFLHDAHPHVIGYFDMFATPSGADNVLSQDEGGRDGATTLVDARRFDAAGPQYPNQSRNDELSKYHDKVLSMVNRLSGEDEFSLHIVMPLMKGDLLYFIKHVSSSGSKPAMTDEFIELVTVVFAFQICFGLDFLHKCNIVHRDIKPENILVRLHGKDPYKSTALIADFGLARDAQASDTFYVCTRYYRPPEIVTNVSGGEPSIDVWSVGCILFEMVTGKALFNVESALNEQGVWDGQLASTQLEVILNIVGTPSHDDIRRFMPVGNAQNYLLRSAPRPSRLVGMMNEQWRLHTTRDRQQKWIDLISSCLAFFPQQRPTCGDLCRHELFQEYNLFYGGNVMQYQPKRYQSAEVNTLKTKNKQSVLHLVRLALQKHSPVVDVSFSDGAKWKDEDEEEGKKSPCAPKERFLDEGELLATPEAVGSDVQDSDMRGEGVTPLEGGSEEGELGESIAFRFLKDSELRRQYDNWGWSGRTRDEVLAKILGDLQRYTHDAVRSEQLRELLRHFSSPR
Protein: Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) (EBNA-3A) (EBV nuclear antigen 3A) (P12977)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
Subcellular location: Host nucleus matrix {ECO:0000269|PubMed:2161150}. Note=Associated with the nuclear matrix.
Interaction partners:
Sequence:
MDKDRPGPPALDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDSSSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPMLPPQPDLPGREAILRRFPLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQAWNAGFLRGRAYGIDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLMRAGKRTEQGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGMAYPLHEQHGMAPCPVAQAPPTPLPPVSPGDQLPGVFSDGRVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERPVYPKPVRPAPPKIAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVPEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDVVQHQLDALGYTLHGLNHPGVPVSPAVNQYHLSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQEEGGQDATEVLDLSIHGRPRPRTPEWPVQGEGGQNVTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA
Protein: Gamma-glutamyl carboxylase-like protein (Q9NDA0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MANSKRKLPTKPSATEDATPHKDTPRSSEEFPTDVNHKSAKKSFLPQNAFFRDCLGHDLSNFTSLTNFTSWLNRPVDGAALGIFRLLYGAAMLIDIAEERGGGQLDVRFQEPLHCHFPLFNGMRALDYPLMGCVYLCMWLGAWGIMLGYRFRTSCLAFLIPYWYIFLLDKPTWNNHSYLFGLVGTLLLFTQAESYCSLDRWLNPRKSHCIPYWNYFLIKFQFFILYMYAGLKKFSLEWLSGYAMSNLSYHWVFAPFRQVIDPELIDLLIVHWFTAFFDVSIAFFMTLEKTRLLVTPFMLSFHLMNSRLFVIGMFPWVCLAEVPLFFSFDWPRRLGNWSKIRDVHPKDPEEELSKPGILARLRTGLILAFCGLQLFLPYSHFITKGYNNWTNGLYGYSWDMMVHSYDTLQTSIQVVDNESRQVHDLNPYAFTEYDRWTKYADMAVQYARCIEENLQEPDIGRNISIYFDIWCSMNGRFQQRSFDPREDLLRAKWSPFESTSWSLPLLNELNHMRPKLRTIETEVLAWNNYSDVIFVADFPGLTLTNFISPDLINCTLTILEGNVRYRNERDPEAYFLTAGKSIGLESNITHLVTTIGQKPASYLFTYTNKTMLEQGITIEQTDTEERSVLPLWQEFQHRVTNYQQFLGHIGNCLMYLLYDVPIPQAVKGGD
Protein: Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (C9JA36)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004655}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004655}. Basolateral cell membrane {ECO:0000256|ARBA:ARBA00037810}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00037810}.
Interaction partners:
Sequence:
MWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGVPRID
Protein: Protein GPR108 (Lung seven transmembrane receptor 2) (Q91WD0)
Organism: Mus musculus (Mouse)
Function: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:30332431}; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:31784416}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TLR3, -7, -4, and -9. {ECO:0000269|PubMed:30332431}.
Interaction partners:
Sequence:
MAVSERRGLSGESPTQCRWGYLSLLVLTLSGCSGRIHRLTLTGEKRADIQLNSFGFYTNGSLEVELSLLRLSLQETEKKLPKVGFSLSRVRSGSVRSYSRRNSHECPLDRNSSNFLVLFLINIKDLQVQVRKYGEQKLFISPGLLPEAPTQSGPPKPDPAGTPKDNHVIHPSPTEMSAVKENQTAPQVSGDKTTPGEHRHSSERQPPTQDPSGKEKDQVLGLGHLNDSYNFSFHIVISSRAEEGQYSLNFHNCHNSIPGQEQPFDLTVMIREKNPEGFLSAAEIPLFKLYLIMSACFLAADIFWVSVLCKNTYSVFKIHWLMAALAFTKSVSLLFHSINYYFINSQGHPIEGLAVMHYITHLLKGALLFITIALIGSGWAFVKYMLSDKEKKIFGIVIPLQVLANVAYIVIESREEGASDYGLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLARLKLFRHYYVMVICYIYFTRIIAILLQVAVPFQWQWLYQLLVESSTLAFFVLTGYKFQPAGDNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL
Protein: Thioredoxin-like protein (Q86HI2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Luminal-binding protein 1
- Luminal-binding protein 2
Sequence:
MKKSIIIIFTILIIFLINSCISQETEQPQQTQQPNNRPSLKDESLIQQLDTNNIDRILNHGNSVWLLKFYAPWCKHSQEFQKTFVEMSHLLKDHLSFGSVDCINDPMLLHRFEITAYPTLKFLYNGQLFEFQGERTIEHIVQFLQAGYKDVVAMPYPLIDQQEILKRQLELQYSREGMSQEQIDQMEKQIKEKQQEYEIKRNARKYLEVEHDHDEEKEIAEYKERINNRKSNNADNGEVLDKEPPKVPGNSTIDSNSINILESILDSKIAYLLFGSISTGLFFIIKKRISKKSKFMKIA
Protein: Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin) (P01034)
Organism: Homo sapiens (Human)
Function: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Subcellular location: Secreted {ECO:0000269|PubMed:20189825}.
Interaction partners:
- Cathepsin B
- Cathepsin S
- Beta-2-microglobulin
- Amyloid-beta precursor protein
- Neutrophil gelatinase-associated lipocalin
- Integral membrane protein 2B
- Hepatitis A virus cellular receptor 1
- C-reactive protein
- Transthyretin
- Cystatin-B
Sequence:
MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
Protein: Bacterial proteasome activator (A0R5Z0)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction (By similarity).
Interaction partners:
- Proteasome subunit alpha
- Proteasome subunit beta
- O-antigen export system, ATP-binding protein
- O-antigen export system, permease protein
- Proteasome-associated ATPase
- Galactofuranosyltransferase GlfT1
- Pup--protein ligase
- Prokaryotic ubiquitin-like protein Pup
- DNA-binding protein
- Pup deamidase/depupylase
Sequence:
MTINPDDDNIEILTGAAGGADTEGEGEGEGKSLTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDDASRNRLREIHQTSIRELEDGLAPELREELERLTLPFTDDNVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRQGALPPGIQVPGAQRGGATHPGTGQYL
Protein: Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) (Q06323)
Organism: Homo sapiens (Human)
Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Interaction partners:
- Proteasome activator complex subunit 2
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-4
- Proteasome subunit beta type-9
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-5
- Proteasome subunit beta type-7
Sequence:
MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY
Protein: Protein CreA (Catabolite regulation protein A) (P0AE91)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Sensor protein CreC
- Transcriptional regulatory protein CreB
- Inner membrane protein CreD
Sequence:
MKYKHLILSLSLIMLGPLAHAEEIGSVDTVFKMIGPDHKIVVEAFDDPDVKNVTCYVSRAKTGGIKGGLGLAEDTSDAAISCQQVGPIELSDRIKNGKAQGEVVFKKRTSLVFKSLQVVRFYDAKRNALAYLAYSDKVVEGSPKNAISAVPVMPWRQ
Protein: TRPM8 channel-associated factor 2 (TRP channel-associated factor 2) (Q921K8)
Organism: Mus musculus (Mouse)
Function: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:A6NFQ2}. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000250|UniProtKB:A6NFQ2}.
Interaction partners:
Sequence:
MATTPDAAFEALMNGVTSWDLPKEFTPSELLLIGEAAFPVMVNDKGQVLIAVSFYGQGRLVVVSHESYLMHAGLAPFLLNAVSWLCPSPGTPIEVHSSLASLVNILRGSGINALVQPEPGEALGVYCIDAYNDTLTKKLVQFVKRGGGLLIGGQAWNWASQHGSDKVLFSFPGNKVTSVAGVYFTDVYGDINRFKVSKKIPKIPLYIRCWEELRHDQDQLLDGISMLDVRTGGVPSQLLVHGSLAFPLGLDNSFLSCFLAAAHYGRGRVVLAAHEAMLCAPKMEPFLLNAIRWLSRGQEDNIGVNTRLKNLNSLLLKHGLKCSLESHLTDDMCVYCCAAYSDQEAKKIQEFVAEGGGLLIGGQSWWWASQNPGSSALGSFPGNVILNTFGLSILPRTVSPGCFPILHIDIRNYHFRGALSEFQAMLNHKEGNLEKRYSGKLGVDGAGFLQIPAQGVPAYLSVHRILRKILRQAGLPAVSKSNPVSSHSYEAAILQLATELAHSGSDCSQIAHNLSSQTCSSNLSSSEHPITVEINGTNPGDRDVWMSTGLYLLEGQSTEISVSEPAASAGLKVQIGCHTDDLTFAIKLFRAPVVTYQCCMNRTQRSVSCLWGGLLYIIVPKGCQLGPVSVTITNAVPAPYYKLGKTSLEEWKSCIQKNLGPWGELATDNVILTVPTASLKTLENPEPLLQLWDEMMQAVARLASQPFPFQRPERIVADVQLSAGWMHSGYPIMCHMESVQELVSLANIRSKGLWGPIHELGHNQQCRGWEFPPHTTEATCNLWSVYVHETVLGIPRAQAHPQLKPEEREKRIKEHLQKGAPLQNWNVWTALETYLQLQEVFGWEPFITLFAEYQTIFYIPEDNECKMNIWLKLFSEKVQKNLVPFFEAWGWPIQKDVAEDLACYPSWEDHPLRMYMGSE
Protein: J domain-containing protein (D7SFQ6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MIVNFATRRMPTLNTFQFDRYKLLCVRNDRELDGYQRSYGDVDSEDESPILRSARSKSGTKAAETSSSQGNFFDSLQFEDRQEPHHFREQRDSTLLDHHDDVTHHTADLLDGFTIGGTEKLSPANETPILSAPTPASSDYDSMTSSQNRRNPSPATAIDDLLGLGTETSAPAPAPSTHFNNSSSGANLVDFDLGAPIKPTSSASNLSTASPATSSWSNTDLLGGFSPMKPQTTSTPPNTRNPSASNSKPVSQVNSQADFEAFLSNYPEQRQAAPQNTQNVSQKTQQTRPQNTYKPAFGDAATGSAKVSMDAFSDLLNQGGFKPTQRENQKQSIGNMLKVEQSKNLTPEEIQIRDWTQGKERNIRALLGSLHNVLWEGADRWNQPSMGDLLTPDQIKKHYRKACLVVHPDKLTGSPHLSLAKMAFTELNDAYSKYQNDPAAM
Protein: Ferric uptake regulation protein (B7J425)
Organism: Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270))
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU364037}.
Interaction partners:
- Thioredoxin peroxidase
Sequence:
MIDERMNSDELKRAGLKATLPRLKILRIFEDSDARHLTAEEIYRLLLETGEEVGLATVYRVLTQFEMAGLVRRHHFEGDKAVFELNETGHHDHMVCTACGKVLEFFDEMLEARQRELAANRGFFISDHSLYLYGTCLGMQDVGICSLRDDDAPGASTD
Protein: RUN/FYVE domain protein (Transposon protein, putative) (Q9C6N3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT5G19950 protein
- Forkhead-associated
- Serine/threonine-protein kinase ATR
- Ubinuclein-1
- DNA replication ATP-dependent helicase/nuclease JHS1
- DNA mismatch repair protein MLH1
- DNA repair protein XRCC3 homolog
- DNA topoisomerase
- DNA topoisomerase 3-alpha
- DNA repair endonuclease UVH1
Sequence:
MPPSPALRCSPGRELPGKKHRRGHSIEYGILFRDKDDDLALFSEMQDKERDSFLLQSSDDLEDVFSTKLKHFSEFTIPVQGESSRLLTAEGDKNDYDWLLTPPDTPLFPSLDDQPPAASVVRRGRPQSQISLSRSSTMEKSRRSSKGSASPNRLSTSPRADNMQQIRGRPSSARHPSPASGRRSGTPVRRISPTPGKPSGPVSRSPTPTSRRMSTGSTTMASPAVRGTSPVSSSRGNSPSPKIKVWQSNIPGFSLDAPPNLRTSLGDRPASYVRGSSPASRNGRDAVSTRSRKSVSPSASRSVSSSHSHERDRFSSQSKGSVASSGDDDLHSLQSIPVGGSERAVSKRASLSPNSRTSRSSKLLSPGSAPRRPFESALRQMEHPKSHHSMFRPLASSLPSTGIYSGKGSSSYHHIMLRHSTATVGSNSSSGQVTGFMPDAKGMDPVPVFQSEVENLAYPDKHEESIAFGMVNLSNESSRHESHESSFSDQLGDMDQDYTVECESSANEEVSHQVFDVENSSTHGSLHVGNEFLEGVALETMEVCGRCGSHYCATEATRSEINICPECREEHSFVETDSPGTNSPKLSQTIFDENKLYFENIPVIDVLDSLPVVMVEEEILETPEKIEQCDNSYEQEQYHLYESSISRALEEQNVDMLNYKDGTQSSTGCGPLSIGTKDTQTQLSDKHHDVNIGSLGRGDVPLVIKRSVSMKSPVIQANNSSCFTRSYEGFSYSRDRSISLRSSTETASASSSWDYGSSIRKGSHIRQRSGSTLDLETHRYDTNSKSLSTMSSSSGMSSHTFQALNVMPEDSFEMCAAQMTCTLDETHQESHTEPQNLECKETNVMNADFVESVGLVRISANVLGDLAEHNPVVMDDECCENGNDVANTVISKGETRESPAHIRSTSDLGASPITDDCPFNDHSRLQENDVNETPHGLSTTTASEIEPESSEPEIPGLGVHDEIPESERNLNAVDDCSEKSMVHASVDHHSSSAPVNEILDESTVLVECPGGKEPRSLTLEEATDTILFCSSIVHDLVYQAATIAMDKAKDVPAEEEMLHPTVTVLGKSNANRNSYGLGGGTKAKKRSSKAAKASRKQTETEEKTEVQIENDENAGEAVMMRNVGVPPSKGENMKPPPNLESKCNCSIM
Protein: Large ribosomal subunit protein uL16A (60S ribosomal protein L10-A) (QM protein homolog) (SpQM) (Q09127)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein uL5B
- Large ribosomal subunit protein eL19A
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL14
- Elongation factor 3
- Large ribosomal subunit protein eL8
Sequence:
MARRPARCYRYCKNKPYPKSRYNRAVPDSKIRIFDLGRKRAGVDEFPLCIHLVSNEYEQITSEALEAARICANKYLVKIGGKDSFHLRVRAHPFHVVRINKMLSCAGADRLQTGMRHAFGKPNGLVARVNIGQILMSVRTKDSSRATAIEALRRCQYKFPGQQRIIVSKKWGFSQYARDEYIEKRSRGEIIPDGCYAKFLNKRGSLQEKLDLFPEASFNLA
Protein: Plasmodesmata-located protein 1 (PD-located protein 1) (Cysteine-rich repeat secretory protein 56) (Plasmodesmata localizing protein 1) (Plasmodesmata-located protein 1a) (PDLP1a) (Q8GXV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell-to-cell trafficking. Required for systemic acquired resistance (SAR) which is mediated by the signaling molecules azelaic acid (AzA), glycerol-3-phosphate (G3P), and salicylic acid (SA). Required for the proper localization and stability of AZI1 which is involved in SAR. Mediates callose deposition during downy mildew fungal infection around haustoria. Haustoria are unicellular protrusions from hyphae and function as the site of molecular exchange of nutrients and effectors between host and pathogen.
Subcellular location: Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:18215111}. Cell junction, plasmodesma {ECO:0000269|PubMed:18215111, ECO:0000269|PubMed:20886105, ECO:0000269|PubMed:25393742, ECO:0000269|PubMed:27078071}. Note=Co-localizes with the Grapevine fanleaf virus 2B-MP at the base of tubules within modified plasmodesmata. Co-localizes with Cauliflower mosaic virus movement protein. Utilizes the secretory pathway for delivery to plasmodesmata. {ECO:0000269|PubMed:20886105}.
Interaction partners:
- PLASMODESMATA CALLOSE-BINDING PROTEIN 1
- Remorin
- Synaptotagmin-1
- LysM domain-containing GPI-anchored protein 2
- Glucan endo-1,3-beta-glucosidase 10
- Probable cysteine-rich repeat secretory protein 6
- Ankyrin repeat-containing protein At5g02620
- Protein trichome birefringence-like 13
- Myosin heavy chain-like protein
- DEAD-box ATP-dependent RNA helicase 47, mitochondrial
Sequence:
MKLTYQFFIFWFFLPFFAISGDDDYKNLIFKGCANQKSPDPTGVFSQNLKNLFTSLVSQSSQSSFASVTSGTDNTTAVIGVFQCRGDLQNAQCYDCVSKIPKLVSKLCGGGRDDGNVVAARVHLAGCYIRYESSGFRQTSGTEMLFRVCGKKDSNDPGFVGKRETAFGMAENGVKTGSSGGGGGGGGFYAGQYESVYVLGQCEGSLGNSDCGECVKDGFEKAKSECGESNSGQVYLQKCFVSYSYYSHGVPNIEPLSGGEKRQHTERTIALAVGGVFVLGFVIVCLLVLRSAMKKKSNKYDAY
Protein: Calcineurin B-like protein 10 (SOS3-like calcium binding protein 8) (SCaBP8) (Q7FRS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Mediates salt tolerance, but only when phosphorylated. Competes with CIPK23 for a direct binding to AKT1, negatively regulating its activity via a protein kinase-independent mechanism.
Subcellular location: Vacuole membrane. Endosome. Cell membrane. Note=Exclusively targeted to the tonoplast when interacting with CIPK24 (PubMed:19832944). PubMed:17449811 indicates a cell membrane localization while PubMed:17825054 shows a vacuole membrane and endosome localization. {ECO:0000269|PubMed:19832944}.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 24
- CBL-interacting serine/threonine-protein kinase 6
- Potassium channel AKT1
- CBL-interacting serine/threonine-protein kinase 11
- CBL-interacting serine/threonine-protein kinase 23
- Sodium/hydrogen exchanger 7
- CBL-interacting serine/threonine-protein kinase 8
- Vacuolar cation/proton exchanger 1
- Respiratory burst oxidase homolog protein B
- CBL-interacting serine/threonine-protein kinase 26
Sequence:
MTTGRPNNILALKISTRSSSLTVGEQFCAVFIPFFAIIDVLVSSVGQCFDCRSTSPRTCQHADLERLARESQFSVNEVEALYELFKKLSCSIIDDGLIHKEELRLALFQAPYGENLFLDRVFDLFDEKKNGVIEFEEFIHALSVFHPYASIQEKTDFAFRLYDLRQTGFIEREEVQQMVSAILLESDMMLSDELLTMIIDKTFADADSDKDGKISKDEWNVYVHKHPSLLKNMTLPYLKDVTTAFPSFIFNTEVED