wanglab/gogpt-training-data huggingface dataset:
Protein: Ran-specific GTPase-activating protein 30 (Ran-binding protein 30) (RANBP30) (P53107)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12578832}. Nucleus {ECO:0000269|PubMed:12578832}. Note=Shuttles between the nucleus and cytoplasm.
Interaction partners:
- Ran-specific GTPase-activating protein 1
- Exportin-1
- GTP-binding nuclear protein GSP1/CNR1
Sequence:
MDEILAKAGSQAVTFAIKSGISIASTYALKTITNFVVQIPKDDARRIDQLKFKLESRMAIVSSAIDLIKLVAARGNTNLQITLRLTKDLKEEIDRFDEKINEMTQKVEGSRSAKTQNEAIKAVENYIKDLLLRIEEITPFINLSLTTSGANLNSALPYQLSPGLLLKASDFVSENNRKYEKAMKSNEKGTGDKEILKVQVGPTFEVTLFSIFYNLTSENNGQSGIVWKEDMKRAKARIYRLNSTGRKYDYFMKIEQDFNDGRYHEDDDKEDTPQELAIDLNHIKKLFFSVSGKLLRLEEQDSPVLVLKIDRSDDKENESSEGDKGLLDDITWYAVSGYEAIEEDEEEDEEEDEEEGKDGEERKEEEEEENKLEDKDSSITLLEYIIRLTSLQSNDQKSILEVSDERLSIYLNDENTNSRKDRISNSTIEETEKKLKNLKL
Protein: UPF0606 protein KIAA1549 (Q68FD9)
Organism: Mus musculus (Mouse)
Function: May play a role in photoreceptor function.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:30120214}. Note=In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment. {ECO:0000269|PubMed:30120214}.
Interaction partners:
- Protein FAM131B
- Serine/threonine-protein kinase B-raf
Sequence:
MEREPRARVALVPERCGRGPSSRHRRPGLLLPGLWLLLLAGPASCAPDDLSLAQHSHPVRPSDFLPERSILHSAAQVTLSETVPRSQPSISALVLSSPSATAFDTAFLSQRQQTQSTAEPSFFEANYGSVTSNEVALDDEEMDNFLPDAHWTSSRGVSPMRYITPSPPEPPQEMLEPGTTPSLPTISLPDEVLSGCQNTVQQATVYVEPSTYFGTSWSAFLTSEGIIPTPSRNSVLHPIEIHSQLSSKALPETVASVTEGAENLLFSSRISVSQPSGNGMTQQPSVPLWEVSQPLVGVLATSSDRYPNETTAWIEHPEEAIALRAHPGITTSPTDPTFSSQPSALFSTPLSSVSFATQLPGVSEDSFLSSEARGALESWHSSPVPSFTDHPYVLSPESSLRPHTGCVSCVVSSFQQELARSLTEKDMGSGDRLETLSTASVEASHVSPLSSVGTDLSELEEPQEFNTLFPSRPVFSFSSRPVGLWKASMDVSPEVDVSGIAITQVYPSHGRLSTPSSLDSTFGFSVTSDLVMSSSMIHLLSSVIPSTHFDSSFSLTANQNSPSFPAGKPSLLTSPSLVPSAQSSAFSHGAPTSSLELQSGSRLDFTSGFYSTPPLDFSTPAPSRSDELAFPSLMSSDPSTFFSQTFSTMAETFSLSNSMNLQSPQLSVLNPTSLEPSQPQSSADLLLNTVTVLPSPPERPPLSSSPSDSLEFTEVSRVSLRESHVHLTSAFSETTSAFEFSPIPHESTISTLVPSSSEPSLGIYAAGTHLTSLPTTVFHLTPILTESSPFSTLTPSDGSVRVTDHHTPVLPTPSSVIPSSTESISDPYLSASSSLVSEVSPSPPPTKPVMGSSLTSTDFPPSTSPELSTSLELSMPSASTAPGDTVDSALNSEPMSQNPQGNSVPPPQPSLGPATTSTLEATVGTPALATAKPPYVCDITVPDVYLITTVLARRAVQEYIITSIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRGQTPLILSVKPSFLVPDPRFQVQTVLQFVPPSVDTGFCNFTQSIEKGLVTALFEVRKHQGTYNLTVQIVNVTIASSRVAPRRGPVNIIFAVKGSQGFLNGSEVSDLLRNLTVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVVEKQLHNEVFPAEMERKLAQLLSEVPTRRRVWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVENQDGERLSAVKSSDLINKVDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVVVGVVIPVLVVTVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPVKDHTTPSENGDVPSPKSKLPSKNIRLRGRVSPSDADSTVSEESSERDAGEKAPAAAPENKALRAPQSGAPLPSSGNEQHSSASIFEHVDRVSRTSEASRRVPSKIQLIAMQPIPAPPAQHPVLADRVAETNKINKEIQSALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPAASVPSVFIEPRKSSRMKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYKRPPGVHNSAYIGCPSDPDLPADVQTPSSTELGRYPGLPFSASQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPTNAMGAGTGVPASLPVNSTPSREERRATQWGSFYSPAQTANNPCSRYEDYGMTPPSGPLPSRPSFGPGLLPSSELVPPEPPQPQSSTDAPYAARGIYSEEMPSVARPRPVGGTTGSQIQHLTQVGIASRIGAQPVEIPAGRGSQYGGPGWPVYGEEEAGRREATHMLGHQEYSSSPLFQVPRTSGREPSAPPGNLAHRGLQGPGLGYPTSSTEDLQPGHSSASLIKAIREELLRLSQKQGSVQNFHS
Protein: Pre-mRNA-processing factor 19 homolog 2 (EC 2.3.2.27) (MOS4-associated complex protein 3B) (MAC protein 3B) (Plant U-box protein 60) (RING-type E3 ubiquitin transferase PRP19 2) (U-box domain-containing protein 60) (O22785)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair (By similarity). Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity.
Subcellular location: Nucleus {ECO:0000269|PubMed:19629177}.
Interaction partners:
- Cell division cycle 5-like protein
- Pre-mRNA-processing-splicing factor 8A
- Pre-mRNA-splicing factor SPF27 homolog
- DExH-box ATP-dependent RNA helicase DExH12
- Protein pleiotropic regulatory locus 1
- Protein pleiotropic regulator PRL2
- Tetratricopeptide repeat
- AT3G18790 protein
- Cwf15 / Cwc15 cell cycle control family protein
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
Sequence:
MNCAISGEVPVEPVVSTKSGLLFERRLIERHISDYGKCPVTGEPLTIDDIVPIKTGEIIKPKTLHTASIPGLLGTFQNEWDGLMLSNFALEQQLHTARQELSHALYQHDSACRVIARLKKERDEARQLLAEVERHIPAAPEAVTANAALSNGKRAAVDEELGPDAKKLCPGISAEIITELTDCNAALSQKRKKRQIPQTLASIDTLERFTQLSSHPLHKTNKPGICSMDILHSKDVIATGGVDATAVLFDRPSGQILSTLTGHSKKVTSVKFVGDSDLVLTASADKTVRIWRNPGDGNYACGYTLNDHSAEVRAVTVHPTNKYFVSASLDGTWCFYDLSSGSCLAQVSDDSKNVDYTAAAFHPDGLILGTGTSQSVVKIWDVKSQANVAKFDGHTGEVTAISFSENGYFLATAAEDGVRLWDLRKLRNFKSFLSADANSVEFDPSGSYLGIAASDIKVYQTASVKAEWNLIKTLPDLSGTGKATCVKFGSDAQYVAVGSMDRNLRIFGLPGDEKANVDDDSAQDS
Protein: Rifin (Q8IK36)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYINILLFELPLNILIYNQRNYYITPRHTETNRSLCECELYSPTNYDNDPEMKRVMQQFVDRTTQRFHEYDERMKTTRQKCKERCDKEIQKIILKHKLEKELMDKFATLHTDIQSDAIPTCVCEKSLADKTEKFCHNCGYGLGSVAPNIGLLGGPGIYVWKIAALAAAKEFAEKAGAAMGKAAGDAAGAAELIRGLKALNIDKLFNESLGLVFDGTNYNNTEYIFKAIFSKFNESCMPRPPGSVPGPVIDRAFCDTVDTLVLPSGTGSQTSASTNAVIKEYVKPIVSNAKFTAEATAQTAAEEATNLALKTNTNAVNATYASSQTAIIVSIAAIVVIVLVMIIIYLILRYRRKKKMKKKLQYIKLLEE
Protein: Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase) (Q80V26)
Organism: Mus musculus (Mouse)
Function: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:18695242}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18695242}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NX62}. Note=The catalytic core is predicted to reside within the Golgi lumen. {ECO:0000250|UniProtKB:Q9NX62}.
Interaction partners:
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
- Inositol monophosphatase 1
- Inositol monophosphatase 2
- 3'
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Myotubularin
- Inositol polyphosphate 1-phosphatase
- Type II inositol 3,4-bisphosphate 4-phosphatase
- Inositol polyphosphate-4-phosphatase type I A
Sequence:
MAPMGIRLSPLGVAVFFLLGLGVLYHLYSGFLAGRFSLFGLGSEPAAGEAEVASDGGTVDLREMLAVAVLAAERGGDEVRRVRESNVLHEKSKGKTREGADDKMTSGDVLSNRKMFYLLKTAFPNVQINTEEHVDASDKEVIVWNRKIPEDILKEIAAPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPKIIVSRSHAGMVKQVALQTFGNQTSIIPAGGAGYKVLALLDVPDMTQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLNGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKSGH
Protein: Zinc finger protein 564 (Q8TBZ8)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDSVASEDVAVNFTLEEWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECKECGKAFNYASSIRIHERTHTGEKPYECKQCGKTFSYSSSFQRHERAHNGDKPYVKNVGKLSFITQPSNTCENE
Protein: GPN-loop GTPase 1 (EC 3.6.5.-) (O42906)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GPN-loop GTPase 2
- Putative RNA polymerase II subunit B1 CTD phosphatase rtr1
- GPN-loop GTPase 3
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerase II subunit rpb7
- DNA-directed RNA polymerase II subunit RPB11
Sequence:
MTDKEKKPCAIIVVGMAGSGKTTFMQQLNAHLHSKNKPPYILNLDPAVRNLPYEANIDIRDTINYKEVMKQYNLGPNGGIMTSLNLFVTKFDQVLKILEKRAPTVDHILIDTPGQIEIFQWSASGSIICDTLASSWPTCIAYVVDTPRATSTSTWMSSMLYACSMLYKAKLPLIIVYNKCDVQDSEFAKKWMTDFEEFQQAVTKDEGMSSEGATSGYMGSLVNSMSLMLEEFYRHLDFVSCSSVTGEGMDDFLEAVKAKVKEYEEEYVPEMERMKEIQRQTKERQKEAQLSKLMKDMHVSKDKEDVGLTVSDAEDEYNGELVDPDEDDGLTAEDREDMIKQYRVALGISDDISDEKLLEMLTERMKQ
Protein: Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) (Q14318)
Organism: Homo sapiens (Human)
Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16176796}. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion membrane {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion membrane {ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Target of rapamycin complex subunit LST8
- Regulatory-associated protein of mTOR
- Heat shock protein HSP 90-alpha
- Proline-rich AKT1 substrate 1
- Heat shock protein HSP 90-beta
- Microtubule-associated protein 1 light chain 3 alpha
- DEP domain-containing mTOR-interacting protein
- Serine/threonine-protein kinase mTOR
- GTP-binding protein Rheb
Sequence:
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
Protein: Bromodomain-containing factor 1 (P35817)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:7791775}.
Interaction partners:
- Transcription initiation factor TFIID subunit 7
- SWR1-complex protein 4
- Vacuolar protein sorting-associated protein 72
- SWR1-complex protein 7
- SWR1-complex protein 5
- Protein AF-9 homolog
- RuvB-like protein 1
- Helicase SWR1
- Bromodomain-containing factor 2
- Vacuolar protein sorting-associated protein 71
Sequence:
MTDITPVQNDVDVNGNNVNDDVSSNLKRPIDQGDPSNGLAEEENPANNQLHLKKARLDGDALTSSPAGLAENGIEGATLAANGENGYNATGSGAEDEQQGLKKEEGGQGTKQEDLDENSKQELPMEVPKEPAPAPPPEPDMNNLPQNPIPKHQQKHALLAIKAVKRLKDARPFLQPVDPVKLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEKHMLNMPAKDAPPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKDIYPYESKKPKSKRLQQAMKFCQSVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEEVFNSKWADRPNLDDYDSDEDSRTQGDYDDYESEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKIRKERRLARGSKKRGKRSKGRSGSKNASSKGRRDKKNKLKTVVTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISEDDEVELDLDTLDNHTILTLYNTFFRQYESSSGASNGLDGTSGVTRDASSLSPTSAGSRKRRSKALSQEEQSRQIEKIKNKLAILDSASPLSQNGSPGQIQSAAHNGFSSSSDDDVSSESEEE
Protein: Piwi-like protein 2 (EC 3.1.26.-) (A8KBF3)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' piwil4. Piwil2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded. Required for piwil4/miwi2 nuclear localization and association with secondary piRNAs antisense. Represses circadian rhythms by promoting the stability and activity of core clock components BMAL1 and CLOCK (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A2CEI6}. Nucleus {ECO:0000250|UniProtKB:A2CEI6}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q8CDG1}.
Interaction partners:
- Polypeptide N-acetylgalactosaminyltransferase
- Tudor domain containing 1.
- Tudor domain containing 15.
Sequence:
MDPTRPPFRGSPFHTPLGVRPPVLETKEEGPHGRAVLLPRGRALLGASAPSSDTTQRDPSDSRNVLPALFRGMGIETKPSGIPGRGGPVFGRGFLSTMSSGDGPDQPLSEPSIRPSLSTRVQQASDFSTERVALGRARFPIPPVSMEKPHVPTGRGLLFPSVLPTLTSDPVPKESPIATLQIEKEEKWEPLPKKGSKGSPCQLGLNLIKINFQNEAVYQYHVTFTPIVECRSMRFGMMKDHRSVTGPVTAFDGSILYLPVKLAQTVELESERRTDGQKIKITIQMTKILDPSSDLCLPFYNVVMRRVFKILDLKLVGRNFYDPASSTVLQQYRLQVWPGYAANIRKTDGGLFLLVDITHKIIRSDSVLDIMNILYQQSPENFQDEVTKQLVGSIVITRYNNRTYRIDDIEWNMSPKDSFSMSDGSKISFIDYYSKNYGITVKELDQPLLLHRPSERKAPKGKALDIVLLLPELAFMTGIPEKMRKDFRAMKDLTQQIHLSPKQHHISLGKLLKRIESSADAKNELQRWGLFLDTDIHMTTGRILPIEKINLRNNSFPAGEDLNWNREVTREACRSSVHLLYWAMIYPKRASAQAQELSSMLERIGGPIGIRVNHPNCVELRDDRVETYARSIKSLLEGEGKVQLLVCLISGTRDDLYGAIKKLCCVQNPVPSQVINTRTISQPQKLRSIAQKILLQINCKLGGELWGVDIPLKSVMVIGMDVYHDPSRGMRSVLGFVASINSCLTAWYSRVVFQLPNQEIMDSLKLCLVAALQKFFEVNHSLPEKIVVYRDGVSDGQLNTVENYEIPQLQTCFQTFDNYNPRMVVIVVQKRVSTNLYSTATGQFLTPQPGTVIDHTVTNRKWIDFFLMSHHVRQGCGIPTHYICVMNTANLGPDHLQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGQFLHHEPSIKLCDKLFFL
Protein: Cyclin dependent kinase like 1 (H0YE65)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKVII
Protein: Alternative squalene epoxidase (AltSQE) (EC 1.14.19.-) (Alternative squalene monooxygenase) (B7FXW1)
Organism: Phaeodactylum tricornutum (strain CCAP 1055/1)
Function: Catalyzes the stereospecific epoxidation of squalene at the terminal double bond to form (S)-2,3-epoxysqualene, the first oxygenation step in sterol biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30478288}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the outer envelope of chloroplasts, which is termed the chloroplast endoplasmic reticulum and is continuous with the nuclear envelope. {ECO:0000269|PubMed:30478288}.
Interaction partners:
- Squalene synthase
- Fatty acid hydroxylase domain-containing protein
- Fatty acid hydroxylase domain-containing protein
- Terpene cyclase/mutase family member
- Reductase with NAD or NADP as acceptor
- 15-cis-phytoene synthase
- Hydroxymethylglutaryl-CoA synthase
- Uncharacterized protein
Sequence:
MLVDRVENNEKQQQQMASSSDAMSDSSLSDDEIIEHVVHGKEPKSTYELSWVSNAIAWSGALVWPLMLTVPLLLSSMYSPISYRQVFPESWYVYDTLSNCAPKPLGLVLGILAVAVGQVFVWIFFYLFKFGYLGTDPRSIQSKGAREYIFREGLLTHIGQPEGFVLLIGYLAITWMLKLMPQSYYSFEGTIQYKELFMCLVLQDGIQYTMHVLEHIVSPAFYQMSHKPHHRFTNPRLFDAFNGSLMDTFCMIIIPLFVTANLVRHCNVWTYMAFGSSYACWLTLIHSEYVFPWDGIFRKLGLGTPADHHVHHKFFKFNYGHLFMWFDQLGGTYRDPSGFAPRVFRENV
Protein: Tissue factor pathway inhibitor (G3V7D5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|PIRNR:PIRNR001620}.
Interaction partners:
- Tissue factor
- Thrombomodulin
- Heparin cofactor 2
- Plasminogen
- Antithrombin-III
- Tissue-type plasminogen activator
- Endothelial protein C receptor
- von Willebrand factor
- Plasminogen activator inhibitor 1
Sequence:
MDPATSLRLWNLPLLLVGSALGLASVSAQGNNLEICLLPLDMGPCKALIPKFYYDRDQKKCRRFKYGGCLGNANNFHSRKLCEHTCGNKEKVPWVCRSAVRTYPCDKPNTEFFFNLKTMTCEPLRPGLCSRTTNVFPEEAMCKSLCEPRKSIPSFCSSPKDEGLCSANVTRYYFNSRNKACETFTYTGCGGNENNFYYLDACNRACVKALKKPKRRKIGDFLPRFWKLRS
Protein: Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D) (P00746)
Organism: Homo sapiens (Human)
Function: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Subcellular location: Secreted.
Interaction partners:
- Complement C3
- Complement factor B
- Adiponectin
- Complement C2
- Resistin
- Properdin
- Leptin
- Resistin-like beta
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Protein: Probable fructokinase-1 (EC 2.7.1.4) (Q9SID0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play an important role in maintaining the flux of carbon towards starch formation.
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
- Sorbitol dehydrogenase
- Hexokinase-4
- Hexokinase-3
- Hexokinase-like 1 protein
- Hexokinase-2
- Hexokinase-1
- Probable hexokinase-like 2 protein
- alpha-D-xyloside xylohydrolase
Sequence:
MASNGDKGLIVSFGEMLIDFVPTESGVSLAEAPGFLKAPGGAPANVAIAVSRLGGRSAFVGKLGDDEFGHMLAGILRKNGVDDQGINFDTGARTALAFVTLRADGDREFMFYRNPSADMLLRPDELNLDLIRSAKVFHYGSISLIVEPCRSAHLKAMEVAKEAGALLSYDPNLREPLWPSKEEAKTQIMSIWDKAEIIKVSDVELEFLTGSNKIDDETALTLWHPNLKLLLVTLGEKGCRYYTKTFKGAVDPFHVNAVDTTGAGDSFVGALLNQIVDDRSVLEDEERLRKVLRFANACGAITTTKKGAIPALPSDAEVRSFLEKK
Protein: INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) (Q9C086)
Organism: Homo sapiens (Human)
Function: Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:15556297, ECO:0000269|PubMed:18922472}. Nucleus, nucleolus {ECO:0000269|PubMed:15556297}.
Interaction partners:
- RuvB-like 2
- Chromatin-remodeling ATPase INO80
- RuvB-like 1
- Actin-related protein 5
- INO80 complex subunit C
- INO80 complex subunit E
- Actin-related protein 8
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Nuclear factor related to kappa-B-binding protein
- TCF3 fusion partner
Sequence:
MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYCSGAQGSTLSFPPGVPAPTAVSQRPSPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQMRLGGPEGPGSPLLAT
Protein: Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (P31240)
Organism: Mus musculus (Mouse)
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
Subcellular location: Secreted. Note=Released by platelets upon wounding. {ECO:0000250}.
Interaction partners:
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor beta
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor C
- Platelet-derived growth factor D
- Pro-epidermal growth factor
- Epidermal growth factor receptor
- Insulin-like growth factor 1
- Vascular endothelial growth factor receptor 2
- Protransforming growth factor alpha
Sequence:
MNRCWALFLPLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHRDSVDEDGAELDLNMTRAHSGVELESSSRGRRSLGSLAAAEPAVIAECKTRTEVFQISRNLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETIVTPRPVTRSPGTSREQRAKTPQARVTIRTVRIRRPPKGKHRKFKHTHDKAALKETLGA
Protein: Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3) (Q14241)
Organism: Homo sapiens (Human)
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Subcellular location: Nucleus {ECO:0000269|PubMed:35633597}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:35633597}.
Interaction partners:
- Elongin-B
- Elongin-C
- RNA polymerase-associated protein LEO1
- RNA polymerase-associated protein CTR9 homolog
- Transcription elongation factor A protein 2
- RNA exonuclease 1 homolog
- DNA excision repair protein ERCC-6
- Superkiller complex protein 8
- Cyclin-T1
- Parafibromin
Sequence:
MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKIKIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR