wanglab/gogpt-training-data huggingface dataset:
Protein: Serine protease inhibitor Kazal-type 1-like (Calcium transport inhibitor) (Caltrin) (Pancreatic secretory trypsin inhibitor II) (PSTI-II) (P09656)
Organism: Rattus norvegicus (Rat)
Function: Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Chymotrypsin-C
- Serine protease 1
Sequence:
MKVAIIFLLSALALLNLAGNTTAKVIGKKANCPNTLVGCPRDYDPVCGTDGKTYANECILCFENRKFGTSIRIQRRGLC
Protein: Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) (P21888)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Serine acetyltransferase
- Serine--tRNA ligase
- Threonine--tRNA ligase
- Leucine--tRNA ligase
- Proline--tRNA ligase
- Valine--tRNA ligase
- Isoleucine--tRNA ligase
- Arginine--tRNA ligase
- Glutamate--tRNA ligase
- Histidine--tRNA ligase
Sequence:
MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVAMVDRMIAEMHKDFDALNILRPDMEPRATHHIAEIIELTEQLIAKGHAYVADNGDVMFDVPTDPTYGVLSRQDLDQLQAGARVDVVDDKRNPMDFVLWKMSKEGEPSWPSPWGAGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGQYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREVNRLKAEDMAAANAMASHLRKLSAVLGLLEQEPEAFLQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEMGIVLEDGPQGTTWRRK
Protein: 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase 2) (Q9M315)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14675432}.
Interaction partners:
- Pantoate--beta-alanine ligase
- Putative 2-dehydropantoate 2-reductase
- Dihydroxy-acid dehydratase, chloroplastic
- Branched-chain-amino-acid aminotransferase 3, chloroplastic
- Putative branched-chain-amino-acid aminotransferase 7
- Branched-chain-amino-acid aminotransferase 6
- Branched-chain-amino-acid aminotransferase 1, mitochondrial
- Branched-chain-amino-acid aminotransferase 2, chloroplastic
- Branched-chain-amino-acid aminotransferase 5, chloroplastic
- Pantothenate kinase 2
Sequence:
MAASLVRSCCSRASRAITTVRFMSNVPEDTVYGGPKPQNSNQRVTLTQLRQKHRKGEPITMVTAYDYPSAVHIDTAGIDVCLVGDSAAMVVHGYDTTLPISLEEMLVHCRAVARGAKRPLLVGDLPFGTYESSTNQAVDTAVRVLKEGGMDAIKLEGGSPSRITAAKSIVEAGIAVMGHVGLTPQAISVLGGFRPQGKNIASAVKVVETAMALQEAGCFSVVLECVPPPVAAAATSALNIPTIGIGAGPFCSGQVLVYHDLLGMMQHPHHAKVTPKFCKQYAQVGEVINKALLEYKEEVSKHLFPGPSHSPYKISSSDLDGFLSELQKLGLDKAASDAAASAEKMDHSDSPSSQ
Protein: Stretchin-MLCK (Q9GV80)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
IVYKVQERCQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLESKWLSQRPDDSLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLELPTKGEAIMRSDFTNTIKMRKKSLEDSAAREKPRSKPQVKPLLCESKLKVSQLKDRFQVSPAPASASASASAANKPPLAYGPFKIAKVASVGRISRTEEPGRSGRGAPSVSGKGKSPQVRSMPSSPLPQRSATPTRLMSQRVREAAERLAQQHTVASAQRHLGNGRGTGTGNGNGNSNSNGNGNGNTAETNRESRARRLINRFNSETQHITS
Protein: Ubiquitin-like protein SMT3 (Q12306)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not known; suppressor of MIF2 mutations.
Interaction partners:
- E3 SUMO-protein ligase SIZ2
- Ubiquitin-like-specific protease 2
- E3 SUMO-protein ligase SIZ1
- SUMO-conjugating enzyme UBC9
- DNA damage tolerance protein RHC31
- Ubiquitin-activating enzyme E1-like
- Ubiquitin-like-specific protease 1
- ATP-dependent DNA helicase SRS2
- Proliferating cell nuclear antigen
- Ran GTPase-activating protein 1
Sequence:
MSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGATY
Protein: Polycystin cation channel PKD1/PKD2 domain-containing protein (D7UU24)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}.
Interaction partners:
Sequence:
MSRRSTTDRSDFNDNASNASSNASRRPTINFQEIMEDLPHHERETGERLRRHLQFFFMNPMEKWKVRHQLPYKLVLQVLKIVFVTMQLILFAEMRMSHVDFLEDTTTVMRHRFLKEWNDDRDALQYPPAEGRYSVYDDQGLSEHLSFLINSYYSIRNDSFASFSYDVVSHPSGNLGAQISFESIPPIEVLIDRISNVTVNNNTYNFDIREVKDTKRLNLTETEVFQIGQSDDAVRDILATRGITFLPEDALKISTVQFKFRLRTIHYSPTAGDQKPECYKISVSIKFDNSRHTGQVHVTLSTVVSYVNVCNGRIIKGVGWSFDTLLIGGTDIFVLILCILSLILCCRALIKAHLLQIKTSDYFENVLKNKITVTDQLDFLNLWYVMIVVNDALIIIGTVAKISIEFQDFDNSLFTLTSIFLGMGALLVYVGVLRYFGFFSQYNILMLTLKRSAPNIMRFMTCAIVLYAGFLIAGWVIIGPYSMKFRTLAESSEALFSLLNGDDMFATFYTINDSNTVIKVFGTVYIYLFVSLFIYVVLSLFIAIIMDAYEVVKDRYSDGLRAIEKRGCLRDFVESNPPPSELGSPTTRSAYAPSNLLNLGRGWQRLE
Protein: FAD dependent oxidoreductase domain-containing protein (Q2UHU5)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Uncharacterized protein
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Glycine cleavage system P protein
- alanine--glyoxylate transaminase
- Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein
- Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein
- 5-aminolevulinate synthase
Sequence:
MTVTKSSSILIIGAGTWGASTALHLGRRGYTNVTVLDPYTVPSAISAGNDVNKIISSGQYSNKKDEIEVNEILAEEAFKGWTTDPLFKPYYHDTGVVMSACSSAGLDRLGIRVRPEEEPDVSEVTKPEHFRQLAPAVLKGNFPGWRGYHIRSNAGWAHARNALVAAIREAEKLGVKFVTGTQGRVITLIFENNDVKGAVTADGKIWRAEQTVLCAGANAAQFLDFKDQLRPTAWTLAHIRLKPEERALYKNLPVIFNIEKGFFFEPDEERGEIKICDEHPGYTNMVKSADGHLTSLPFEKTQIPKESEARVRALLSETMPQLADRPFSFARVCWCADTANREFIIDRHPEHPSLVLGCGASGRGFKYLPSIGNLIVDAIEDKVPEKVHKLTRWSPDIAVDRKWRDTLGRFGGPNRVMDFHDVKEWTNVQNKDTAKL
Protein: Inner kinetochore subunit cnp3 (CENP-C homolog) (Centromere protein 3) (Constitutive centromere-associated network protein cnp3) (Q9USR9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Monopolar attachment protein 1
- Inner kinetochore subunit cnp20
- Monopolin complex subunit pcs1
- Histone H3.1/H3.2
- Histone H3-like centromeric protein cnp1
- Inner kinetochore subunit mis6
- Inner kinetochore subunit fta1
- Kinetochore protein nuf2
- Tripeptidyl-peptidase 2 homolog
- CENP-A histone chaperone scm3
Sequence:
MTMNETSAIPARQRENQFFEIGVVGRKTGFTVPRDVKKGDDGFEDMDAYFLSDGSIHLDEDNGDIEQDMPPVTRLQPTSPMAVNAASDEASHASSSDSSDKNPDIPSSPLLMNSRALRASRGSSGPLIVPIDHSAFQAEDEGTADKTKVDGNKLSIQPRKANRIVDFSRIKASPDRKKFEPRRSTELPSKIPSSTPKDDNVQESPAFPDENITALQKNVANFTSIKDSGGRDNLYIQTISKPRRSYVQNNKSEQTIKPSKQNKQKEEKKTISQGNKPNSRDEDSELSIDVPLSMLNRSLANNSQKNKKRTPNKPLQESSINSVKEGESNPVVKRKRGRPRKNKLEIGNSVQTSEATQVKGAKKPAIRNAKKMSNEKDDSLNSQSDSASGEFIKTIARNNLQEIKQVEREDTLVGVRRSKRTRIAPLAFWKNERVVYELHRDENRIPALPEVKQIIRVDDPSPSIRQGRKKRHAKRSGVEIKSNLEAKSNDVEEYDAFYKDEINCEVLSWNEQNPKASEERVVGYSLPSVNLQQISNQQLKFASLFKEEPSFAAGVVEMPAGAEKPVKPSKHNIMSFCILQGKIEVTVNATTFRMKKDGVFIVPRGNYYSIKNIGKEAVRLYYTHATDTLENKRRGIGDFPNER
Protein: Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) (O43053)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12001}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichyl-phosphate beta-glucosyltransferase
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dol-P-Man:Man
- Alpha-1,2-mannosyltransferase alg9
- UDP-glucose:glycoprotein glucosyltransferase
- Probable Dol-P-Man:Man
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Uncharacterized protein C7D4.09c
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- GDP-Man:Man
Sequence:
MLSEFENGAPVQQFVSRFRSYSSKFLFFPCLIMSLVFMQWLISIGPYSGYNTPPMYGDFEAQRHWMELTLHTPVSQWYFRDLQWWGLDYPPLTAYVSWFFGIIGHYFFNPEWFADVTSRGFESLELKLFMRSTVIASHLLILVPPLMFYSKWWSRRIPNFVDRNASLIMVLFQPALLLIDHGHFQYNCVMLGLVMYAIANLLKNQYVAATFFFCLALTFKQMALYFAPPIFFYLLGTCVKPKIRFSRFILLSVTVVFTFSLILFPWIYMDYKTLLPQILHRVFPFARGLWEDKVANFWCTLNTVFKIREVFTLHQLQVISLIFTLISILPSCVILFLYPRKRLLALGFASASWGFFLFSFQVHEKSVLLPLLPTSILLCHGNITTKPWIALANNLAVFSLWPLLKKDGLGLQYFTLVLMWNWIGDMVVFSKNVLFRFIQLSFYVGMIVILGIDLFIPPPSRYPDLWVILNVTLSFAGFFTIYLWTLGRLLHISSKLSTDLRNKKEA
Protein: Uncharacterized protein (Q583Z1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 60S ribosomal protein L35A, putative
- Large ribosomal subunit protein uL3m
- 60S ribosomal protein L21E, putative
- Nucleotide exchange factor Fes1 domain-containing protein
- Eukaryotic translation initiation factor 6
- 60S ribosomal subunit protein L31, putative
- 50S ribosomal protein L13, putative
- Ribosomal protein L37
- Potassium voltage-gated channel, putative
- Ribosomal protein L15
Sequence:
MSARMQVPLSQRRHTNVAAVRYTKNGHKLEIACYKNKVISYRNGVETRLDEVLQIDRVFTNISRGLFASEKDIQAVFGKGTTEEDALKYILVHGELQVAQHEREVEVNQMFTDIALIISQKCVNEVTQRPFPAQVIEQALRSIGAAVRLDQPAKKQALALIHRLMDAQIIPIARAPMKLRCTTVDEQSLKKVTEWCESNRATILEEPGETCQDETVHGAGKYSLLILLQPHLFRDLEIFVKDELPHGATVHMIDSVAMDVGEVDVMDADLIARANAHTNAADKSVGGGGGSHQTGSSSNPTQCLNNNNKGGKKGGKSGRKQKNAKYSLQKNDDTPQEEQGTPLTADLSSTGPGVVDDKEISDVKTALSKLGLDNPCALDDHDDDDKNKRGKKKAKRRQGAQQQSQQPASSKKEVEVEAQEDSDEEVLVNRKQRKMAAVKAKDISNNHDCDFDDEYNYEYDMEEGVGEE
Protein: Ofd1 centriole and centriolar satellite protein (A0A8I6AA62)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAQSTMPHKCDDVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLVHELMHPVLSGEVKPPSISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKIFTMQDLLQLIRINPSSSLYKSLISGFDKDNQKGFLMSFLKELAEYHQTKESCDVETQTSTTFPSQVSLAEKFQLIDDQFAEAFPHRPKLESLETKLNEYKKEIQQQLQVEMCQKLKYFREAEITKVRMEEKRKYEKELAEFRNEFERTCQAKNEALISQEKNTLERIKKHQEMETKEIYAQRQLLLNDIDLLRGREAELKERIEAFELTQKLQEEKNKNEAEALRRREQNLKNIEEAYEQKLKTELLKYQLELKDDYITRTNKLLEEERKNKEKTFHLQEELTVINSKKEELSKSVQRMKEVELELESVKAQFFAMSKQNHSLNEKLKEMSDYSQLKEEKVELQAQNKLLKQQLEENRNENLRLLDRITQPPPELLVFQKELQKTEKAMALEHKGFETHRQALQKQLQSEIENSTQLRTQISEYDASVKRLTVQVADLKSQLKQTQTALENEVFRNPKRSLTLHSLTGLLSGKMAPHNEDTSGDFLNVPLEQNKVMAGAVVSRVTPYVNTATEASSPDSDLEFVASSTKAKVKELEQEAERLEKAFRTYYQRVTQNPSMSPQPAKSPSSVYSVGALRSIASSSRDRHVPAEDRVVSEQPLADILKEEKSDVSKAFVGSMVSRPRRTSSSTRLSSTPHPKSRRSLDNEMYLEGLRRLHITSSSPCLDRPSESPAASPTPCPERTPQPSSVPSRHSFSGPSFSSPPEQNASLYQRQTEMQDKSEFSNVDKQSLKDKEKFEPSFRWNKPEQFEAEGLHPAGDMPGIDVAAATLSSRPISYNHPSGAVQSQTGEQKEQQIWELHMKERRQREEQRQNERQEALERERRELEKLEQERRMIEESLKSEIEEELEKSVQEQKDKSAHGENPLEKYMKIIQQRQEQSSADKSSKKSGKECSLVDMMIPSDKDDRYGFLQTLCPSGKSLLLLLSAKIIR
Protein: Glycerol kinase 2 (GK 2) (Glycerokinase 2) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 2) (Glycerol kinase, testis specific 2) (Q9WU65)
Organism: Mus musculus (Mouse)
Function: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation. Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis.. Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:28852571}; Single-pass type IV membrane protein {ECO:0000305|PubMed:28852571}. Cytoplasm {ECO:0000250}. Note=In sperm the majority of the enzyme is bound to mitochondria. {ECO:0000269|PubMed:28852571}.
Interaction partners:
- glycerol kinase
- Monoglyceride lipase
- Glycerol-3-phosphate acyltransferase 3
- Glycerol-3-phosphate acyltransferase 1, mitochondrial
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Glycerol-3-phosphate acyltransferase 2, mitochondrial
- Non-selective voltage-gated ion channel VDAC3
- Glycerol-3-phosphate acyltransferase 4
- Aldo-keto reductase family 1 member B1
- Aldose reductase-related protein 2
Sequence:
MAASKQTSAGPLVGAVVQGTNSTRFLVFNSKTAELVCSHQVELTQEYPKEGWVEQDPKEILKSVYECIAKACEKLAEVNIDISNIKAIGVSNQRETTVVWDKFTGDPLYNAVVWLDLRTQSTVETLTKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNLRPIQKAVEEGRAMFGTIDSWLIWCMTGGVNGGIHCTDVTNACRTMLFNIHSLEWDKDLCDFFEIPMSILPNVCSSSEIYGLMTSGALEGVPISGCLGDQSAALVGQMCFHEGQAKNTYGTGCFLLCNTGQKCVFSEHGLLTTLAYKLGKNKPVFYALEGSVAIAGAVIRWLRDNFEIITTSGEVENLAREVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNRILMQLQADILHIPVVKSVMPETTALGAAMAAGAAEGVNVWSLEPEDLSTILMERYEPQIQATESEIRFSTWKRAVMKSMGWVTAKDPENGDNPVFSCLPLGFFIVSSMTLLIGARCVSTAEE
Protein: Programmed cell death protein 2-like (Zgc:56288) (Q7ZV10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MATSIHETVLIGICDGAIDKKKNASYCTNKIGDRPDLLPIITLQYPSCSLCQRGLSHVVQVYCPLAASPYHRTINVFACTSPQCYGKSESWIVLRSQCLEDDIKERQDHKTTQCAEPTMSRTDWCDEADDWGMDDEVAISAVEKPIDSVGEGNDVSSKLQELCIDGGVDHQSAPQSDNVPVFKPFYISVMEETDLDGFQDVDHENELLREYEERERVSVEEIQSCESGEAREEYEKGTAKHGDDTFTGFMKKISLCPEQVLRYSWNGSPLFIMKPPCNASQMVPSCSHCGSLRVFEFQLMPALVSLLGSADTNSEISLEFGTVLVYTCRNSCWKSGSTVPVEEFLFVQPDPDQKYFK
Protein: Protein kinase superfamily protein (Q0WSF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNNSTSVKRLVSSKAMKCFYFSKDKTQDDEAKTRKFGSATMARGGSGSEFNSDTSTATSITSSLHVLSETHSNNLKVFVLDDLKTATKNFSRSLMIGEGGFGGVFRGVIQNPQDSRKKIDIAVKQLSRRGLQGHKEWVTEVNVLGVVEHPNLVKLIGYCAEDDERGIQRLLVYEYVQNRSVQDHLSNRFIVTPLPWSTRLKIAQDTARGLAYLHQGMEFQIIFRDFKSSNILLDENWNAKLSDFGLARMGPSDGITHVSTAVVGTIGYAAPEYIQTGHLTAKSDVWSYGIFLYELITGRRPFDRNRPRNEQNILEWIRPHLSDIKKFKMIIDPRLEGNYYLKSALKLAAVANRCLMVKAKARPTMSQVSEMLERIVETSSDGAPSGLPLMKSLTPKDAFEASRRERVKRRFVELLIGENGCPNLPTWSHKLVTSI
Protein: Lectin-like protein LEC (AtLEC) (Ath.lec2) (Q9LJR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in defense responses triggered by jasmonate, ethylene and chitin.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:18324730}.
Interaction partners:
- Nuclear transcription factor Y subunit B-9
- B3 domain-containing transcription factor LEC2
- PLC-like phosphodiesterases superfamily protein
Sequence:
MQIHKLCFLALFLANAAFAVKFNFDSFDGSNLLFLGDAELGPSSDGVSRSGALSMTRDETPFSHGQGLYINPIQFKSSNTSSPFDFKTSFTFSITPRTKPNSGQGLAFVIVPAADNSGASGGGYLGILNKTNDGKSENNLIFIEFDTFKNNESNDISGNHVGININSMTSLVAEKAGYWVQTLVGKRKVWSFKDVNLSSGERFKAWIEFRSKDSRNTITIAPENVKKPKRPLIQGSRVLNDVLLQNMYAGFAGSMGRAGERHDVWSWSFEN
Protein: Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Q80XI6)
Organism: Mus musculus (Mouse)
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent. {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- C-Jun-amino-terminal kinase-interacting protein 2
- Dual specificity mitogen-activated protein kinase kinase 7
- C-Jun-amino-terminal kinase-interacting protein 1
- C-Jun-amino-terminal kinase-interacting protein 3
- Mitogen-activated protein kinase kinase kinase kinase 1
- Glutamate receptor ionotropic, kainate 2
Sequence:
MEPLKNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPTESGQTWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRAGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMPSPCPPELPSTPLIRLSQTTPDAHSSPTPGPLLLDLGVPSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDMGAQAPWAPEAGP
Protein: Basic helix-loop-helix neural transcription factor TAP (Protein biparous) (Target of Poxn protein) (O16867)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- LD18634p
- Protein daughterless
- Worniu
Sequence:
MAACYNAYSAGSQSFEFDEDDDDASFDSGYEKSFETEAQLSSRRRLDFGTPPTPAIPQPYSGGTWDAVPLSSPPAGFVGLLDTSSNHSTRSGRTLVEHLNSRATNGVFDPPLTSTPVKSPEDPNAPRPKRKYAVGKNRVTRSRSPTQVVKIKRFRRMKANDRERNRMHNLNDALEKLRVTLPSLPEETKLTKIEILRFAHNYIFALEQVLESGGSINLDLEKLQNFTLSGERITKELFDALFVNPQPYPLFGRMFPYGQGMAPLAQHQTAPASHAEQPPAMGGFQHGMDYPQQPPGFDFTGSMRFYHQQQQQPHQPHHLQPNPQQESSPQQFSQEKYDLFRGSFDAAANLHSTNLDSGIHQQSSFYSQTPPWKDYPEDQAHVHPVPHQHSYKNFAPQV
Protein: D-xylose reductase [NAD(P)H] (EC 1.1.1.307) (C8VSG5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MSLEHTKKVYTLNTGDKIPAIGLGTWQSKPNEVREAVKNALLKGYRHIDTALAYGNEAEVGQGIKDSGVPREEIWITTKLDNTWHHRVTDGINSSLKDLGVDYVDLYLMHWPSSTDPNDLKKHLPDWDFIKTWQEMQKLPATGKVRNIGVSNFGIRNLEKLLNDPSCKIVPAVNQIELHPNNPSPKLVAYNSSKGIHSTGYSCLGSTNSPLYKDPTLLKLAEKKGKTPQQVLLVWGIQKGWSVIPKSVSKSRIDANFEIDGWSLTDEEINELDNLKDRFKVCGDDWLPIKVFFGDDE
Protein: Hexose transporter HXT15 (P54854)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
Sequence:
MASEQSSPEINADNLNSSAADVHVQPPGEKEWSDGFYDKEVINGNTPDAPKRGFLGYLIIYLLCYPVSFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIECERHEEACVSIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSKAMSISTAFNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEEIQLLYEEGIKPWKSASWVPPSRRGASSRETEAKKKSWKEVLKFPKSFN
Protein: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form] (Q812G0)
Organism: Mus musculus (Mouse)
Function: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2}.; SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]: Secreted {ECO:0000250|UniProtKB:O77836}.
Interaction partners:
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Alpha-
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Sequence:
MRLRNGTVATALVFVTSFLTLSWYTTWQNGKEKLIAYQREFLALKERLRVAEHRISQRSSELNTIVQQFRRAGAETNGSKTALSTISDNTIKLLKELTSKKSLRVPSIYYHLPHLLQNERSLQPAVQIGSGRTGVSIVMGIPTVKREVKSYLVETLHSLIDNLYPEEKLDCVIVVFIGETDLDYVHSVVANLEKEFSREISSGLLEIISPPESYYPDLTNLKETFGDSKERVRWRTKQNLDYCFLMMYAQEKGIYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMFQAPDLALVVEFILMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQHVGLHSSLSGKIQKLTDKDYMKPLLLKVHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWAITPTAGDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVDVLPLKSDSLEISKETKDKRLEDGYFRIGKFEYGVAEGIVDPGLNPISAFRLSVIQNSAVWAILNEIHIKKVTS
Protein: Heat shock factor 2-binding protein (O75031)
Organism: Homo sapiens (Human)
Function: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9D4G2}. Chromosome {ECO:0000269|PubMed:31242413}. Note=Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes. {ECO:0000269|PubMed:31242413}.
Interaction partners:
- Breast cancer type 2 susceptibility protein
- Break repair meiotic recombinase recruitment factor 1
- Spermatogenesis-associated protein 22
Sequence:
MGEAGAAEEACRHMGTKEEFVKVRKKDLERLTTEVMQIRDFLPRILNGEVLESFQKLKIVEKNLERKEQELEQLKMDCEHFKARLETVQADNIREKKEKLALRQQLNEAKQQLLQQAEYCTEMGAAACTLLWGVSSSEEVVKAILGGDKALKFFSITGQTMESFVKSLDGDVQELDSDESQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTILQLLGDLKPGQCTKLKVLMLMSLYNVSINLKGLKYISESPGFIPLLWWLLSDPDAEVCLHVLRLVQSVVLEPEVFSKSASEFRSSLPLQRILAMSKSRNPRLQTAAQELLEDLRTLEHNV
Protein: At4g02850 (Phenazine biosynthesis PhzC/PhzF family protein) (Q66GM9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAMLVKKPVKYFMVDAFTESAFKGNQAAVCFLEEDHERDDVWLQSMASEFDLPLTCFLIPIPGSEPPRFLLRWFTAVAEMDICGHATLASAHSIFSNSLVGSSDTVEFSTNSGILTAKRLSDCDSKRSFLIEMNFPVITTCEYSSKDVSIFSKALNGATIVDVRETKTDRLIFKPLIGAFKTTSTDQIIVVLSSWESVIEFQPRVDDIVKCPGKVMIVTAAAPQGSPFDFCSRLFAPKLGLNEDSVCGSAHCSLAHYWSLKMNKCDFVAFAASQRSGTLKVHYDKEKQRVLLTGKAVTVMKGSILV