wanglab/gogpt-training-data huggingface dataset:
Protein: Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) (Q61187)
Organism: Mus musculus (Mouse)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99816}. Early endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99816}. Late endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99816}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q99816}. Nucleus {ECO:0000250|UniProtKB:Q99816}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000250|UniProtKB:Q99816}.
Interaction partners:
- Vacuolar protein sorting-associated protein 37A
- Vacuolar protein sorting-associated protein 28 homolog
- Programmed cell death 6-interacting protein
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Vacuolar protein sorting-associated protein 37B
- CD63 antigen
- Ubiquitin-associated protein 1
- Centrosomal protein of 55 kDa
- Multivesicular body subunit 12A
- Multivesicular body subunit 12B
Sequence:
MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTATGPPNTSYMPGMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
Protein: Signal transducing adapter molecule 1 (STAM-1) (P70297)
Organism: Mus musculus (Mouse)
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:Q92783}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92783}; Cytoplasmic side {ECO:0000250|UniProtKB:Q92783}.
Interaction partners:
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- STAM-binding protein
- Tumor susceptibility gene 101 protein
- Signal transducing adapter molecule 2
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase JAK2
- Vacuolar protein-sorting-associated protein 36
- Ubiquitin-ribosomal protein eS31 fusion protein
- Vacuolar protein sorting-associated protein 28 homolog
- Charged multivesicular body protein 3
Sequence:
MPLFATNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQSAPVSTLYPSTSNLLTNHQHEGRKVRAVYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGVGLFPSNFVTADLTAEPEMIKTEKKTVQFNDDVQIETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQQYYLQSSAVSASQVYPGPAQSGTYLVAGSAQMTHLQSYSLPPEQLSSISQGAVPSSANQALPSQQTQASYPNAMVSSVQGNSYPSQASIYSPPAAAAAAAAAAVVPVPVPADVTIYQNAGPTMSQVPNYTLTSSTLPQTGGSQQPPQPQQAYSQKALL
Protein: FG-GAP repeat protein, putative (Q57WA0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PTHB1 N-terminal domain-containing protein
- FG-GAP repeat protein, putative
- Bardet-Biedl syndrome 8 protein
- Uncharacterized protein
- BBSome complex member BBS5 PH domain-containing protein
- Uncharacterized protein
- Kinesin, putative
- Kinesin-like protein
- Kinesin, putative
- Kinesin-like protein
Sequence:
MISSHDIELVGREIASVSSTFPRCLVVYPLGKKNKQRLGIGERDGVVSSFSVGKGNERSVAFSTPPRSHPVSCMTLYDDQVFFVHGSKLVAYSRKGREFFAFDTNVTETPHTIFVSTPFIIICGSFMVTGFCEATELGFYMAPDHINAMVAFIAPSAQKRSSVTFSDYRCVIGCSDRVVRMLCDNKLLSELSCEAAISALCVSETQNAVYYGTEAGSLGCLDFCKSNVILTRVFSYIPSDAQPSVTALTVRDINSDSKEEVVVGRLDGSVQVFLVDKGEESDELTPVCIWSGCVDGRVLTIETGFVTHSQMLDVIVHSFSGKITAFTVKEVERVPKGETVPMELIEDSVDEQIEAMEREIERLRKELMDTTQELARCTGSTVVNAPVLAVSSTFTSKCTISQQAESPALLLTIESDTPLDNIVLHSDVELHFLQSVGVTMVEQAVGPENNPCGVTRAILRPLREHMYGCSVRFWLEDGRLGAVKLTLLAAPAPRTAQVKTVMLRPLPLFSRVGCSDVADDNDHDSVEVTDPSAAQSVLEVEGDFTARDMHSWLQRMLPGTPELYRANQATLHYENVFFHSIIKVEYGDRRAAFFTGSLVALSAIKCFLTSCGLERSLEVKVVVSLHDNALQCELQHIATRIAACNKVVSDVQLIEAIREMQGDCEGCDMSFLLEERNRLLAEPEVVGKDRSRALQNKEYLQRFLLRLYNGASDIMPRPPKATSAVGEALGAACNCGDATALLAELRRIFRC
Protein: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 (EC 2.1.1.14) (Cobalamin-independent methionine synthase 1) (AtMS1) (Vitamin-B12-independent methionine synthase 1) (O50008)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:15024005}.
Interaction partners:
- Adenosylhomocysteinase 2
- Adenosylhomocysteinase 1
- S-adenosylmethionine synthase 4
- Homocysteine S-methyltransferase 2
- S-adenosylmethionine synthase 3
- Homocysteine S-methyltransferase 1
- S-adenosylmethionine synthase 1
- S-adenosylmethionine synthase 2
- Homocysteine S-methyltransferase 3
- Cystathionine beta-lyase, chloroplastic
Sequence:
MASHIVGYPRMGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQMSAAGTKFIPSNTFAHYDQVLDTTAMLGAVPPRYGYTGGEIGLDVYFSMARGNASVPAMEMTKWFDTNYHYIVPELGPEVNFSYASHKAVNEYKEAKALGVDTVPVLVGPVSYLLLSKAAKGVDKSFELLSLLPKILPIYKEVITELKAAGATWIQLDEPVLVMDLEGQKLQAFTGAYAELESTLSGLNVLVETYFADIPAEAYKTLTSLKGVTAFGFDLVRGTKTLDLVKAGFPEGKYLFAGVVDGRNIWANDFAASLSTLQALEGIVGKDKLVVSTSCSLLHTAVDLINETKLDDEIKSWLAFAAQKVVEVNALAKALAGQKDEALFSANAAALASRRSSPRVTNEGVQKAAAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVRREYKAKKVSEEDYVKAIKEEIKKVVDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYGDVSRPKAMTVFWSAMAQSMTSRPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALREGLPLRKSEHAFYLDWAVHSFRITNCGVQDSTQIHTHMCYSHFNDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSSEEIADRVNKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKNMVDAAKLIRSQLASAK
Protein: CD154 (CD40 ligand) (B8YI05)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- CD40 molecule, TNF receptor superfamily member 5
- TNF superfamily member 13b
- CD28 molecule.
- CD4-1 molecule
- CD27 molecule
- Furin b
- Tenascin C
- Zmp:0000000846
- Tenascin R
- Tenascin N
Sequence:
MINTFHSSYNPPPVPPRAGYKKAQPSGNTPLVKFLSVMLLLLMTLTFGGFLYLFQKVNGELQWVYQEDTATLKKLQQCANGNRAQECQILIEKVNTVMGKVSLENGTFSKFTGGPSRNGPAAHMVFLSEHNEKYKESEALRSNSLLWDKERSLLQGVQITVKRDRLTIQTPGVYFIYSQVTFSRRATKNPLKQTINRSGPKNENKELLKSFCTLHENTEEMCTASSAGVFRLEKDQQVYVTVTDRSLVNKKYCWFGLFKL
Protein: Progonadoliberin-1 (Progonadoliberin I) (G8HN01)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MEKSRKILVGVLLFTASVAICLAQHWSYGLQPGGKRNAENLVESFQEIANEMESLGEGQKAECPGSYQHPRLSDLKETMASLIEGEARRKEI
Protein: Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] (P01942)
Organism: Mus musculus (Mouse)
Function: Involved in oxygen transport from the lung to the various peripheral tissues.
Interaction partners:
- Hemoglobin subunit beta-1
- Haptoglobin
- Globin b2
- Hemoglobin subunit beta-H1
- Small ribosomal subunit protein eS12
- Hemoglobin subunit epsilon-Y2
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS3
Sequence:
MVLSGEDKSNIKAAWGKIGGHGAEYGAEALERMFASFPTTKTYFPHFDVSHGSAQVKGHGKKVADALASAAGHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLASHHPADFTPAVHASLDKFLASVSTVLTSKYR
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Somatomedin) (P08025)
Organism: Rattus norvegicus (Rat)
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05017}.
Interaction partners:
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor 1 receptor
- Insulin-like growth factor-binding protein 3
- Insulin-2
- Insulin-like growth factor-binding protein 1
- Insulin receptor
- Insulin-like growth factor-binding protein 5
- Insulin-1
- Insulin-like growth factor-binding protein 6
- Cation-independent mannose-6-phosphate receptor
Sequence:
MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSARSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM
Protein: Oligo-1,6-glucosidase IMA1 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 1) (P53051)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization. Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14576278}.
Interaction partners:
- Invertase 2
- Glucoamylase, intracellular sporulation-specific
- General alpha-glucoside permease
- Maltose fermentation regulatory protein MAL13
- Maltose permease MAL31
- Maltose fermentation regulatory protein MAL33
- Mannosyl-oligosaccharide glucosidase
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
Protein: LP14866p (Q5BI67)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MLHNNAPWLPPHQQQQQQAPQQHPTPQQQHAMPQQQQTLPAQQQQQQVYASQMFQQHQPNYWPEDQHQQQQQPQSLNYNNYFPGQQQQHPMQQQQLPPQQQLPPQQQQPTQQQHTIQQQLYYPTQQQPQVPAPAEPALDSFDNNNSGGGGGGGRSDGWGDWGDWNDNSNNNNSNGTDGLLEPTGQLLEDSFNVQSSQGSWQAFATSNNVNNNGELPPPANPQSTSLQQQPLNQQSIPLLHQQPQSPPELGQEPELDAIVPPQAFQNQPPTAAPPPTSLTSFSAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVGAPPVGAPPADATTIAPPAALPPSIVPSSGSNPFKRSTGLNKRVNIMADPAAGAPSPPAPAAAIAPVAPVAPIPPPADQLFGMPAEAHGEGFNLIAAPPVEASLGTPLSAPIPAPIPVPNASLYASPAVPQAFAHLEPDNQEVLSAPNDERAQYLQTSHLSEQLGEGEADQDAGLLPPPGLSRLVLGQPELDSQQQRQVTGATEQPPLNVAQAAALHMQERRADGEDTSDGEQQVRNIQTPPRRVVTGVETNAPSLREQREVVLDGENLEDREAIPPPTLAELPTTSVHHNILPDEAEQLHHNNPPQAMTPLNAQQPHQQQSTLQQQHQQHSTTQQEKKRAAVGRRTTASLDLESDESDEFLQSERERDRERERRDLMEERHSRGRSHSHYPYEGETEDSVRGAAHHETKSLRETHHKRNHDSARSRRHQDPKVERERERDRERDRTWRRRSNKYHSGGEDPDRSYDHSRRYNNSNYEGESDNPEYNHMGDAELDGSGGRSSKTSRHRRSAAEEDFDDYERERNRSRRSTKPQSSAEKSRSSGGRRNYENSGRSARADDGRRRYHDQRNPGAQYPVSATGYVPYGMYEQMSRNPQVYADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERAAADAAPSTYGGVAGTAGPVTNTAVARPPRRRTPLQFSRPHLVASYAMSLLLKVKPKYAGRGRLRNDVEVAPPRIRDGTSSLLRMYPGPLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHALMWHLLILLLRQNGYIADTDVGDLLLENQQEYPYDPSEFEAENEPDADAEQDAAAPADKTVDSDLDSESAAGVTPAEPLAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGDWRSHLSILVTNKSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSATELTTLTANVPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARHIELKPESYDSNFIQRVCGLAERLRYHDPILINRVSFASPPNATSKDSAAAEEKAWLRQLRSLAYVQPQQEQLQQLQQNQQVQQEQNDIDQQFAEVNKQFRELNMQYESNSNMENTLQPQLPPVDQQPPQQQQQVLSESYQQPTQQYYEPPPQAPTESDPYGQGQPSYYDPNAGQLHYDPNAAQHQYDQQQPQPQPTPSYGQIEPGTEAYQPGQATADPAAVPSGYGYDYWSGTQQPPYGDELQQQTRPAISMPKSKSYGDEDDGGSGGVADPGQKTKPVGSSEAAGKQQASGKQANSGSDLGAPGNKNAGWFGGLWNKLSLKPKNQMILPDDKNPAIVWDKERKCWTNTEGNGDEAESFKPPPKMSDLGMALGGPPAAPIGNAGLGMGLMPVANNAPGSHQSAPLMDQQTPSQPQTYGSPIDYTAAPAPELIPTVPSPAPLSVPSSAPASCREE
Protein: Ubiquitin carboxyl-terminal hydrolase 50 (EC 3.4.19.12) (Deubiquitinating enzyme 50) (Ubiquitin thioesterase 50) (Ubiquitin-specific-processing protease 50) (Q6P8X6)
Organism: Mus musculus (Mouse)
Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q70EL3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q70EL3}. Nucleus {ECO:0000250|UniProtKB:Q70EL3}. Note=Accumulates in the nucleus following DNA injury. {ECO:0000250|UniProtKB:Q70EL3}.
Interaction partners:
Sequence:
MCFIDMASHRPVPADDFGAYYNLAECADYDSLPESKTQPHFQGVTGLRNLGNTCYMNAILQCLCSVSPLVEYFLSGKYITALKKDCSEVTTAFAYLMTDMWLGDSDCVSPEIFLSAVGSLYPAFLKKTQQDAQEFLIYVLNELHEALKKHCRRRVNEKRTGQSCCRKVPAQETSIITRLFEGQLSYSITCLKCESCTHKNEVFTILSLPIPSDYECSLQDCLQCFFQQDTLTWSNQIYCSFCEIKQEAAVRTTISKVPKIIVFHFKRFDIQGTVKRKLRTDIHYPLTNLDLTPYICPVFRKHPMYNLCAVVNHFGDLDGGHYTAFCKNSVTQAWYSFDDTRVSEIPDTSVQTATAYLLFYSCQPFSIPAQKRKSQDSTPDHCKQAIRKWP
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q381G2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSREERSCRMCHSSAGKCVSPCCCDGSIKYVHSKCLARWVRHRKSLICEVCGTPCRVAKLSSYSISATNYRWVTLIWIFSRVWIRENARILSISLLVPIFSWLTFVLEGSLKGAGSIYSPVKVTLTHTHTLSEWGPTEALSYTVWVLTKLTAASMLLKLVREHWPGIEPFVREAPNADEQGRPVLEGRAVNQLQNWRTDAVEEGKEGEYDASGEGGDVEGEPMVSATSGLIVEVAVHPRDDGVVLQAIEAAHSDAGKSKTLRGKLKEELLHLVLPFFFLNVFCTVLCVLAPEVVRIKMWELWVAVDGNSRAWEVADTLLATLSPSENVARMRGAMVKPLIEALGSSDLLHAPLYFARLTFVIWIVVFVMKGVRCVPLRTFVLEALSLLRCIMAALVLPTFFIRTTTLLVLFLSMDFFDDDRNVGIAEDKKRAWQVITTPVSVRHEDERPTTLLVLKSLKTVLGSERREVCFDFGAARVLRSGINATVDQGVTLDGEEAEDPVLFFLFALSVIVSVVDMPSMWPASDVILAVVISQFFFIVGFATRLPGRWFRWTMLHKVASVTGLRQLCALLDLWALLRVCAEINFIVAVICGGFLPYAFGAYQFFSRNDKPLVLLVTRNLLSSFRWAKGVFMLVDVSLNIAWYVDSRLGDKMGELFDVRGLALGDGISITGFLSKALRCTAFVACSSICSCIWIGICLALFDCLVVRSSCFVDTFFYGCRCIITVYMINDNEAWSRMLSIVELPFKGVRQFTEWKCRWLFSSSFGIWAGPQYVDGVNVAQRELTLITGMPTWYTHLCCSRIMVALDELQRNATADDAEVIQRVAIEITPLIRREEQACTLTEEQMMILFRCLKFPGMGRLLTLLLVAALLLLALPFMVGACVVSSVLALFLSPSCVVASGFVCGFLWVVGVVATGTLIILTDKLKSDLGPVRLYFSCGCHHMPLFEALAFAVMPIFMTTTTFIVFPFALAVMAWPHVRQVDSFGAFFMRFDIATLCLIFRLLLRCWTRLSPAVFAFFGRVQQVRVRNDGENSRVVSAPQEVAAPAAAKPGASAVLMVREATANMWKGCVDVGFECCAKLCYVRNHILRRLVETAESESIVGVAFIDRPT
Protein: UDP-glucuronate:xylan alpha-glucuronosyltransferase 1 (UDP-GlcA:xylan glucuronyltransferase 1) (EC 2.4.1.-) (Glycogenin-like protein 1) (Plant glycogenin-like starch initiation protein 1) (Protein GLUCURONIC ACID SUBSTITUTION OF XYLAN 1) (AtGUX1) (Q9LSB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glycosyltransferase required for the addition of both glucuronic acid and 4-O-methylglucuronic acid branches to xylan in stem cell walls. In association with GUX2, is responsible for almost all of the substitutions of the xylan backbone in stem glucuronoxylan.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:20852069, ECO:0000305|PubMed:21124849}; Single-pass type II membrane protein {ECO:0000305|PubMed:20852069, ECO:0000305|PubMed:21124849}.
Interaction partners:
- Beta-1,4-xylosyltransferase IRX9
- Probable galacturonosyltransferase 12
- Protein IRREGULAR XYLEM 15
- Xylan O-acetyltransferase 1
- Cellulose synthase A catalytic subunit 7
- Cellulose synthase A catalytic subunit 4
- Probable beta-1,4-xylosyltransferase IRX10
- Glucuronoxylan 4-O-methyltransferase 3
- Probable galacturonosyltransferase-like 1
- Cellulose synthase A catalytic subunit 8
Sequence:
MANSPAAPAPTTTTGGDSRRRLSASIEAICKRRFRRNSKGGGRSDMVKPFNIINFSTQDKNSSCCCFTKFQIVKLLLFILLSATLFTIIYSPEAYHHSLSHSSSRWIWRRQDPRYFSDLDINWDDVTKTLENIEEGRTIGVLNFDSNEIQRWREVSKSKDNGDEEKVVVLNLDYADKNVTWDALYPEWIDEEQETEVPVCPNIPNIKVPTRRLDLIVVKLPCRKEGNWSRDVGRLHLQLAAATVAASAKGFFRGHVFFVSRCFPIPNLFRCKDLVSRRGDVWLYKPNLDTLRDKLQLPVGSCELSLPLGIQDRPSLGNPKREAYATILHSAHVYVCGAIAAAQSIRQSGSTRDLVILVDDNISGYHRSGLEAAGWQIRTIQRIRNPKAEKDAYNEWNYSKFRLWQLTDYDKIIFIDADLLILRNIDFLFSMPEISATGNNGTLFNSGVMVIEPCNCTFQLLMEHINEIESYNGGDQGYLNEVFTWWHRIPKHMNFLKHFWIGDEDDAKRKKTELFGAEPPVLYVLHYLGMKPWLCYRDYDCNFNSDIFVEFATDIAHRKWWMVHDAMPQELHQFCYLRSKQKAQLEYDRRQAEAANYADGHWKIRVKDPRFKICIDKLCNWKSMLRHWGESNWTDYESFVPTPPAITVDRRSSLPGHNL
Protein: Phosphoserine phosphatase (PSP) (EC 3.1.3.3) (Q72H00)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Function: Catalyzes the last step of the phosphorylated serine biosynthetic pathway, i.e. dephosphorylation of O-phospho-L-serine to form L-serine. Is also able to dephosphorylate O-phospho-D-serine with similar efficiency. Displays a poor activity on L-phosphothreonine, and cannot use L-phosphotyrosine, pyridoxal phosphate, glucose 6-phosphate, or fructose 6-phosphate as substrates.
Interaction partners:
Sequence:
MKLLLLDLDDTLLQDLPVSRAVLEDLGRKAGVEGFFARVKARAEALFREAPFYPWAEAIGHSALEALWARYSTPGLEALAAWAGPFRERVFREALEEAGGAPERARELAEAFFRERRRYPLYPEAEAFLAEARRRGLALALLTNGVPDLQREKLVGAGLAHHFSLVLISGEVGIGKPDPRLFRMALCAFGVAPEEAAMVGDNPQKDVRGARLAGVRAVWVDRGLRPEDPEASPDLRVGDLREVFLAEAL
Protein: Sister chromatid cohesion protein SCC4 (Protein SISTER-CHROMATID COHESION 4) (AtSCC4) (Q9FGN7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:28137757}. Cytoplasm {ECO:0000269|PubMed:28137757}. Note=Associates with chromatin, especially during telophase, prophase and interphase. Mostly localized in the nucleus during interphase and preprophase stages, but not in the nucleolus. During prometaphase, metaphase, anaphase and telophase, mostly cytoplasmic. {ECO:0000269|PubMed:28137757}.
Interaction partners:
- Sister chromatid cohesion protein SCC2
- Structural maintenance of chromosomes protein 3
- Wings apart-like protein 1
- Wings apart-like protein 2
- Structural maintenance of chromosomes protein 4
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- Sister chromatid cohesion 1 protein 1
- Sister chromatid cohesion 1 protein 4
- Sister chromatid cohesion 1 protein 3
- Structural maintenance of chromosomes protein 6A
Sequence:
MEGAAVAEGLWGLADHHQKLGEIGKTIKCLEAICQSQISFLPLVEVKSRLRLAALLLRYSHNVNHAKSHLERSLLLLKSIPSSYDLKFQNYSLLSHCYHLLASFPPQRNLLVKALELASSVPQDISAYLWSCNFNSQLANTFIIQADFPSSLSALESGFLSASHICFPELQMFFTASMLHVHIMQWTDDYSVEKAVQRCDEIWQTISSDKTDRCPGLFFYNEMLHVFYRLRLCDYKNAQHHVDRLDQAMNAHSHKMQEIQQLLDELSSLNLSLSRYDLPSRERSALSARQSQLQDRVNALSPSSSTVNSLEPAYFGNIDRGWTEKLLLSPSPIDGEWLPKSAIDALVHLMVVISGRPKGLFKECSKRIESGLQIIQDELIKLGITDEVREADLRHTAIWMSRVFLMLQMQFLENRVALELTRSDYVEAEEALVDMKNWFTRFPTILQASECMIEMLRGQYSHSVGCYSEAAFHCIEATKLTESISMQASCQAFAAVSYLTIGDAESSSKALDLIGPLNGMTNSLSGVREEASILFAYGLLLMKQRDLQEARNRLAKGLQIAHNHMGNLQLVAQYLTLLGNLALSLHDTVQAREILRSSLTLAKKLYDIPTQLWVLSIFTALYQQLGEKGNEMENEEFRKKKWDELQSRLAEARGSIHHIELVAKARIELYQIDNNPQEQSLVASAQSMQGNLDIPESVGIEGPSPAPSSSRLVGLDTGKRWGKRRM
Protein: Antifungal protein 1 (Pf-AFP1) (P84884)
Organism: Passiflora edulis (Passion fruit)
Function: Has strong antifungal activity against T.harzianum, F.oxysporum and A.fumigatus with IC(50) values of 32 ug/ml, 34 ug/ml and 40 ug/ml, restectively. Lacks antifungal activity against R.solani, P.brasiliensis and C.albicans.
Interaction partners:
Sequence:
QSERFEQQMQGQDFSHDERFLSQAA
Protein: Interferon-induced transmembrane protein 5 (Bone-restricted interferon-induced transmembrane protein-like protein) (Bril) (Dispanin subfamily A member 1) (DSPA1) (Fragilis family member 4) (O88728)
Organism: Mus musculus (Mouse)
Function: Required for normal bone mineralization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18442316, ECO:0000269|PubMed:24715519}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:18442316}.
Interaction partners:
- Cartilage-associated protein
- Trimeric intracellular cation channel type B
- Prolyl 3-hydroxylase 1
- Peptidyl-prolyl cis-trans isomerase FKBP10
Sequence:
MDTSYPREDPRAPSSRKADAAAHTALSMGTPGPTPRDHMLWSVFSTMYLNLCCLGFLALVHSVKARDQKMAGNLEAARQYGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLSKLAKDSAAFFSTKFDEEDYN
Protein: Sclerostin domain-containing protein 1 (Ectodermal BMP inhibitor) (Ectodin) (Sclerostin-like protein) (Uterine sensitization-associated gene 1 protein) (USAG-1) (Q9CQN4)
Organism: Mus musculus (Mouse)
Function: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Subcellular location: Secreted {ECO:0000269|PubMed:14623234}.
Interaction partners:
Sequence:
MLPPAIHLSLIPLLCILMRNCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS
Protein: Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) (P28228)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
- Gap junction alpha-1 protein
- Gap junction alpha-5 protein
- Hyperpolarization activated cyclic nucleotide gated potassium channel 4.
- Gap junction protein
Sequence:
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIAFRIALTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQNQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEENLPADLETLQREIKMVQERLDLAIQAYSHQNNPHGPREKKAKVGSKAGSNKSSASSKSGDGKNSVWI