wanglab/gogpt-training-data huggingface dataset:
Protein: Non-reducing polyketide synthase albA (NR-PKS albA) (EC 2.3.1.-) (A2QUI2)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of aurasperone B, a dimeric gamma-naphthopyrone. The first step in the biosynthesis of aurasperone B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units. YWA1 is then methylated by aunE at position C-6 to yield foncesin which is further methylated at position C-8 by aunD to produce fonsecin B (Probable). A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase aunB which catalyzes the oxidative dimerization of fonsecin B to aurasperone B. AunB also catalyzes the oxidative dimerization of rubrofusarin B into aurasperone A.
Interaction partners:
Sequence:
MEGPSRVYLFGDQTSDIEAGLRRLLQAKNSTIVQSFFQQCFHAIRQEIAKLPPSHRKLFPRFTSIVDLLSRSRESGPSPVLESALTCIYQLGCFIHFYGDLGHDYPTPSNSHLVGLCTGVLSCTAVSCARNVGELIPAAVESVVIALRLGICVFRVRELVDSADSESTCWSALVSGISEAEASHLIDEYSSKKATPPSSKPYISAVSSNGVTVSAPPTVLDEFVETCISKNYKPVKAPIHGPYHAPHLYDDKDIDRILQQSSALEGLTGCSPVIPIISSNTGKPIKAKSIKDLFKVALEEILLRRLCWDKVTESCTSVCKTGTNHSCKLFPISSSATQSLFTVLKKAGVSISLETGVGEIATNPEMRNLTGKAENSKIAIIGMSGRFPDSDGTESFWNLLYKGLDVHRKVPADRWDVDAHVDMTGSKRNTSKVAYGCWINEPGLFDPRFFNMSPREALQADPAQRLALLTAYEALEMAGFIPDSSPSTQRDRVGIFYGMTSDDYREINSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHMACNSIWRNDCDAAITGGVNILTSPDNHAGLDRGHFLSTTGNCNTFDDGADGYCRADGVGSIVLKRLEDAEADNDPILAVINGAYTNHSAEAVSITRPHVGAQAFIFNKLLNDANIDPKDVSYVEMHGTGTQAGDAVEMQSVLDVFAPDYRRGPGQSLHIGSAKANIGHGESASGVTALVKVLLMMRENMIPPHCGIKTKINSNFPTDLAKRNVHIAFQPTPWNRPASGKRRTFVNNFSAAGGNTALLLEDAPIPERQGQDPRSFHLVSVSARSQSALKNNVEALVKYIDSQGKSFGVKETEFLPNLAYTTTARRIHHPFRVIAVGANLQSLRDSLHGALHRETYTPVPSTAPGIGFVFTGQGAQYSGMGKELYRSCFQFRTTIEHFDCIARSQGLPSILPLVDGSVAVEELSPVVVQVGTTCVQMALVNYWTALGVKPAFIIGHSLGDYAALNTAGVLSTSDTIYLCGRRAQLLTKECKIGTHSMLAIKASLAEVKHFLRDELHEVSCVNAPAETVVSGLVADIDELAQKCSTEGLKSTKLKVPYAFHSSQVDPILEAFEDIAQGVTFHKPTTPFVSALFGEVITDANWECLGPKYLRDHCRKTVNFLGGVEATRHAKLTNDKTLWVEIGSHTICSGMIKATLGPQVTTVASLRREEDTWKVLSNSLASLHLAGIDINWKQYHQDFSSSLQVLRLPAYKWDLKNYWIPYTNNFCLSKGAPVATVAAGPQHEYLTTAAQKVIETRSDGATATVVIENDIADPELNRVIQGHKVNGTALCPSSLYADISQTLAEYLIKKYKPEYDGLGLDVCEVTVPRPLIAKGGQQLFRVSATADWAEKKTTLQIYSVTAEGKKTADHATCTVRFFDCAAAEAEWKRVSYLVKRSIDRLHDIAENGDAHRLGRGMVYKLFAALVDYDDNFKSIREVILDSEQHEATARVKFQAPQGNFHRNPFWIDSFGHLSGFIMNASDATDSKNQVFVNHGWDSMRCLKKFSPDVTYRTYVRMQPWKDSIWAGDVYVFDGDDIVAVYGAVKFQALSRKILDTVLPPVGASKGPARPAASAQKAAPAAAASKSRASAPAPAKPAAKPSAPSLVKRALTILAEEVGLSESEITDDLVFADYGVDSLLSLTVTGRYREELDIDLESSIFIDQPTVKDFKQFLAPMSQGEASDGSTSDPESSSSFNGGSSTDESSAGSPVSSPPNEKVTQVEQHATIKEIRAILADEIGVTEEELKDDENLGEMGMDSLLSLTVLGRIRETLDLDLPGEFFIENQTLNDVEDALGLKPKAAPAPAPAPAPVPAPVSAPILKEPVPNANSTIMARASPHPRSTSILLQGNPKTATKTLFLFPDGSGSATSYATIPGVSPDVCVYGLNCPYMKTPEKLKYPLAEMTFPYLAEIRRRQPKGPYNFGGWSAGGICAYDAARYLILEEGEQVDRLLLLDSPFPIGLEKLPTRLYGFINSMGLFGEGNKAPPAWLLPHFLAFIDSLDTYKAVPLPFDDPKWAKKMPKTFMVWAKDGICSKPDDPWPEPDPDGKPDTREMVWLLKNRTDMGPNKWDTLVGPQNVGGITVIEGANHFTMTLGPKAKELGSFIGNAMAN
Protein: Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif serine/threonine-protein kinase 3) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (mPar-1c) (Q8VHJ5)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q9P0L2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9P0L2}. Note=Appears to localize to an intracellular network. {ECO:0000250}.
Interaction partners:
Sequence:
MSARTPLPTVNERDTENHTSVDGYTETHIPPAKSSSRQNLPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLSDAKRIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGSLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWGKDTARRLGSTTVGSKSEVTASPLVGPDRKKSTASPSNNVYSGGSMARRNTYVCERSTDRYAALQNGRDSSLTEMSASSMSSAGSTVASAGPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGAAQRVPAASPSAHSISASTPDRTRFPRGSSSRSTFHGEQLRERRSAAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRADTARGSSGDPKERDKDEGKEAKPRSLRFTWSMKTTSSMDPNDMLREIRKVLDANTCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Protein: Inactive CLIP domain-containing serine protease A8 [Cleaved into: Inactive CLIP domain-containing serine protease A8 light chain; Inactive CLIP domain-containing serine protease A8 heavy chain] (A0A1S4H5S2)
Organism: Anopheles gambiae (African malaria mosquito)
Function: Inactive serine protease which plays an essential role in the innate immune response against bacteria, fungi and protozoa infection by activating the melanization cascade. In the melanization cascade, acts downstream of TEP1 and SPCLIP1 to promote CLIPA28 and CLIPC9 proteolytic cleavage and CLIPC9 recruitment to microbial surfaces. In the resistant strain L3-5, required for the melanization of killed parasite P.berghei ookinetes which results in their clearance. In the susceptible strain G3, appears to be dispensable for ookinete elimination which occurs by lysis. Required for the melanization of Gram-positive and Gram-negative bacteria. During the late stage of fungus B.bassiana-mediated infection, required for the initiation of hyphae melanization by promoting prophenoloxidase PPO activation.
Subcellular location: Secreted {ECO:0000269|PubMed:17537726, ECO:0000269|PubMed:33045027}. Note=Secreted into the hemolymph. {ECO:0000269|PubMed:17537726, ECO:0000269|PubMed:33045027}.
Interaction partners:
Sequence:
MPSWWCCCCLVVLLYAQRMIVPSSAQNDGSDELQECPGGFCSPKYLCPNGTYNEANAQNQEIIMLRFGEEDVCQDYMQVCCSNATSMRYELVTNNEPVEYGCGISNPGGLIYQVEGNRTYAQYGEFPWVVAILEAFYSSNEQQFTYVGGGTLIHPRFVVTAAHIFNKTENLVASFGEWDMNRDENVYPKQNIDIDRTIIVHPEYNSVGLLNDIALAQLKQNVVYDKHIRPICLPNPTDRFDDQLCISTGWGIEALTSAYANVLKRVDLPVIARASCKKLFAETRLGPFFRLHKSVLCAGGEEGADMCDGDGGSGLACPNESGAYVLAGIVSWGLSCHQQNVPGAYVNVARFVTWINATIEGIL
Protein: Probable polyketide synthase 16 (dipks16) (EC 2.3.1.-) (Q869W9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable polyketide synthase.
Interaction partners:
- holo-[acyl-carrier-protein] synthase
- 4'-phosphopantetheinyl transferase domain-containing protein
Sequence:
MTFNNIKDENNDDIAIIGMGFRFPGGGNNPDQFWNQLSNKMDGISKISQEKWSRSFYEQKYINNEYGGVLKDEEWKNFDPLFFGISPKEAPTIDPQQRLLMTTLWEAFEDANIKPSTLRGSDTAVFIGMMNLDYQRCQFRDISYINPYTVTGSAGSFVSNRLSFSFDLRGPSMTLDTACSSSLNAVYLGCQAIATGDSKMAIVGGVNGIFDPSISMTFSGLNMLGHKGQCRSFDAGADGYIRSEGGGVCILKKYSDAIKDGDRIYCVIKGGSSNVDGYNAKTNITQPSMKAQGENIEIALKKSGVNPSDIYYIEAHGTGTPVGDPIEIEAISRIFKDNHTPDAPLYIGSVKSNIGHLESAAGIASLIKVALSLKNRSLVPNIHFEKPNPLIKFEDWNIRVVTDEIQFPTNKLINMGINCFGLSGSNCHMILSEAPINYDELLKTTNNNSTSSSSNDDKKEYLIPFSANCNISLDKYIEKLISNQSIYKDTILFKDFVKHQTISKSNLIKRKVITASDWDDFLNKRNETTSTSSLTSTISAPASSTPVIYVFTGQGPQWRDMGKALYETESVFKDAIDHCDKLLANYFGYSILQKLRSLESDDSPEIHHPILAQPSIFLIQVGLVALYKSFGISPSIVVGHSFGEVSSALFSGVISLETAVKIVYYRGLAQNLTMGTGRLLSIGIGADAYLEKCALLYPEIEIACYNDPNSIVITGSEQDLLGAKSTLSAEGVFCAFLGTPCSFHSSKQEMIKEKIFKDLSDLPESNVPCVPFFSTITGSQLSHKGFYNVQYIYDNLRMPVEFTKAISNIFNFIEENESYKNAIFLEIGPHPTLGFYIPKCKPSNSTITSKPIIVSPLHKKKEELTQFKLAISTLYCNGVEIDFASGQQLLPTSSSSGGGDISSFKESTNKLPRYQWDFEEYWDEPNQSKMVKRGPSNNLLGHDQFAGNTLMELFIDINKSAHQYLKGHKIKGKYLFPGSGYIDNILRQFNGQDITIFNLEFSNPFFLKDGVQHHLQTSITPTTKGEFKVEFFIKDNRNSTKWTKTSNGRIGLFKHNPKNNKLDIEKLKSQCSFTTLTKSEVYNKLLLLSLPYGPTFQRVESCSIGDGCSFFKLSMSPCSEFDKDFLNPSIIDCAFHGLLVLSEGPQEIVFDRLQDMKFYSSNVPSTRPQFIYAFAKFDKIVGNSTHGSLDIMLEDGTLLISIKNVKCTSLIRLKKQSIKYPSQNVYSHHWQSKDSPLTLIENQLIEEKSSESKINFEKLLNDKLFNDYLIRLLNQSIKSEFIEFDYKTSTVDTLEIDSNNTKLLEKIQSILKTIDSLDQSIDLASLKQVIIEKSSSFKKEINLIEKSIKRIVSLLKGGESEHFSPSNPSSPNDTPRYNSNNCSSKSNNTSSGADDDTNNEETINQLNNEPFNFSNSQFISNQNQLISKTIVNSFDRLINSIEIGEKKLIKIIDLSSIYQNNQLSKLLLLQLNQLLINLSNNNNIEIEYTIPSNTKNIDSIKEETKSISNLLNIKYRSFDLQDDLESNGYLNSNYDLIITSLLLVSTNSIDSNEVLSKLYKLLLPKGQLILMEPPKDVLSFNLLFANDFKQSLEIKSEQEIKSLIRYCGFTKIETNNITQDDEEEQQQPPSILIVQTEKRDIESMSLTFSSDPESLNSSYSNCIFIVSKEQKENPTSYIQEYFDITEVFCDNTTIIEAGDSELLTKTIESGIGKNDIIFFLVSLEELTIENYKQVTMQYTLVNQILLRNNLSTRFALLTYDSQNGGKNYLGSSLIGTFRYFLEFPSLNTFSIDVDKDSIDNLTLFLRLVDLSTIGDRETIVRNNKIFVQKIFKEPKLLSPSNNYEKDTNNLYLNTNSNLDFSFQCKEKLPHGSVEIKVMSTGINYKDNLFYRGLLPQEIFTKGDIYSPPFGLECAGYITRVAPSGVTRFKVGDQVVGFASHSLSSLAITHQDKIVLKPENISFNEAAAVCVVYATSYYSIFHIGAFMADKESILVHSATGGVGLATLNLLKWKRNQLKKHGNSEISNDASIYATVGSKEKVDYLQEKYGDLITAIYNSRDTEYCDEIKQQSAQGGVDLILNTLSGDYLSANFRSLSQVGRIMDLSVTQLVENDSLDFSNFKYHVTYSTIDLERATTYNSKIVRDILTEVFDAISDGSLENIPVKVFPATQVKTAIEYINERVHIGKIVVDFENFEQDILKPALQEKENPIQLNKVKKLEHTCDTLNNTILITGQTGIAVHILKWIISGSVLNSNKSQQQVTDFIILSRSSLKWELENLINQTKHKYGDRFRFHYKSVNIADLNSTRTAIDQVYSSCKNVSPIKSVLHFATVYEYILPEDITQTVIDNTHNPKAVGAINLHNLSIEKDWKLENFILFSSIGAIIGGSKQCAYSSANLVLDSLSNYRKSIGLASTSINWGGLDAGGVAATDKSVASFLEGQGILLVSLSKILGCLDSVFQPSNSHLSNFMLSSFNIDNLLSSAPQMKRKMGHHLTNYKTSSASSDDSLGDSSSTQAKVISTISELLSIHPSKLNLDTRLKDYGIDSLLTVQLKNWIDKEFTKNLFTHLQLSSSSINSIIQRISSKSTSTSTPNPTNTTKQTATTKT
Protein: Ras association domain-containing protein 10 (A6NK89)
Organism: Homo sapiens (Human)
Function: Plays an important role in regulating embryonic neurogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20956940}. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.
Interaction partners:
- Ras association domain-containing protein 7
- Ras association domain-containing protein 6
Sequence:
MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV
Protein: Pebbled, isoform A (Pebbled, isoform B) (Q9W4J1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription factor Jra
- Transcription factor kayak, isoforms A/B/F
- Zinc finger protein ush
Sequence:
MLAAQQQHNNSTVESEMERQRRDSTTSESSLEHLDLGRTPKKLGGNSGSTQTTSTPHELATVTSSRKRKIRHLQLNHHQQQQHHQQSDLLSDEDVAEAEAEEDEDEEDGDQVAALGSRNLGRHKQRRSGGATTQASIVMDYSSGDASSLRKKFRLNRSAASLSESGFVDASSTTGHSGYLGNSSSATNTTATSGIGASAVAPSPVGGAAINAASSSSGSSSGGSGGSSPQGQCLSSGESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQVAQSQSQSQQQQSLQQQQQSQQQRRQQQQHQPSQQQQNPAQQQLMGNTLSARAESYESDASCSTDVSSGHSHSRSSSSLNNNNNNSHKANNNLKDLEELEVSTEDQDTENKQRRLKTTINNNIIESEQQEDMDDEEADDADVAMLTSTPDVATLLAGASASGAASRSPTPSPSASPALLLSCPACGASDFETLPALCVHLDAMHSDIPAKCRDCEVIFATHRQLQSHCCRLPNALAGGLPPLLGASSSPLHNEEPEDEEHGDDEDLEQKERLASQSEDFFHQLYLKHKTANGCGAISHPPSPIKHEPADTKDLADIQSILNMTSSSSSFLRNFEQSVNTPNSSQYSLDGRDQEEEAQDAFTSEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRVHLGAVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREEVKRAIVYHPAEDAGCEDSKSRLGEDLADTSFRSISPTPPPPPVNESKSQLKHMLLGENHLAPVNQQPPLKIQVKSLDQLVDKKPSAPAPQQQQQQQQQEKSGSALDFSMDVLDLSKKPTGGASLTPAVTRTPTPAAVAPVTPGGVGTPDLAAAIEQQQLLLAQQQLFGAGGEYMQQLFRSLMFQSQTSGFPFFPFMAPPPPQANPEKPPMVSPPNRINPMPVGVGVGVPVPPGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRGASNVAAAAAAAAAAAAATVMAGGPGSSGFGSNHHHGHGHGSHGSHGHAPISEQVKCAILAQQLKAHKNTDLLQQALAHGSSSVAGNPLLHFGYPLTNPSPMHNGSSQGNGQATAMDDDEPKLIIDEDENEHDHEVEAEDVDDFEEDEDEEEMDEPEDEPELILDEQPAEKEAEEEQELPKPLEQLGTKEAAQKMAETILEQAIKAGKPLSPPPTKENASPANPTVATTMQEPAITAPSTNPSSLKTMIAQAEYVGKSLKEVASSPFKDESQDLVPVAKLVDNATSQNMGFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQEAEREKELELERERELERERELERERQLEKEKERERQQLIQKLAAQMNAAATAAAVVAAASAVNGGASGGPHGPIADALAGGDLPYKCHLCEGSFAERLQCLEHIKQAHAHEYALLLAKGAIETESLEANPHQQPSQQAVHSDDEAPNGGGNRGKYPDYSNRKVICAFCLRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHSGRAHNGDTPGSDCSDDEQVSSPPSTPHPTQPTSANNNNSCHNNNNNANNNNNNNNNNNNNNSSSKLGLKLHDLLDKASEWRASRLGEHKENMGEATPSGATVAGSDLIGNLLGISDQGILNKLLSSADEAAKLLGVDNK
Protein: Small ribosomal subunit protein uS12m (37S ribosomal protein S12, mitochondrial) (O14182)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS19m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein mL41
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein bS6m
Sequence:
MIRFAQYARYPVISRLMKPTVISPFQAQAFSSSSVMLKTLNQTIRNKEKRPEKTNKQSVALEGSPFRRGVCTRVFTVKPKKPNSAVRKVARVRLSTGRSVTAYIPGIGHNAQEHAVVLLRGGRAQDCPGVQYHVVRGVYDIAGVAGRVTSRSKYGVKKPKAA
Protein: Bifunctional chorismate mutase/prephenate dehydratase (Chorismate mutase-prephenate dehydratase) (P-protein) [Includes: Chorismate mutase (CM) (EC 5.4.99.5); Prephenate dehydratase (PDT) (EC 4.2.1.51)] (P0A9J8)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- T-protein
- Aromatic-amino-acid aminotransferase
- Anthranilate synthase component 1
- Bifunctional protein TrpGD
- Chorismate synthase
- Histidinol-phosphate aminotransferase
- Aspartate aminotransferase
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
Sequence:
MTSENPLLALREKISALDEKLLALLAERRELAVEVGKAKLLSHRPVRDIDRERDLLERLITLGKAHHLDAHYITRLFQLIIEDSVLTQQALLQQHLNKINPHSARIAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIENTSSGAINDVYDLLQHTSLSIVGEMTLTIDHCLLVSGTTDLSTINTVYSHPQPFQQCSKFLNRYPHWKIEYTESTSAAMEKVAQAKSPHVAALGSEAGGTLYGLQVLERIEANQRQNFTRFVVLARKAINVSDQVPAKTTLLMATGQQAGALVEALLVLRNHNLIMTRLESRPIHGNPWEEMFYLDIQANLESAEMQKALKELGEITRSMKVLGCYPSENVVPVDPT
Protein: Toll-like receptor 7 (Q5GQ97)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasmic vesicle, phagosome {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
VHHARTSNALLFVLLFLFPMLLSGRWFPKTLPCDVEAFESTVRVDCSDRRLKEVPRGIPGNATNLTLTINHIPRISPASFTQLENLVEIDFRCNCVPPRLGPKDNVCVTPPSIENGSFAALTRLKSLYLDANQLSKIPRGLPATLRLLSLEANNIFSIKKNTFSELRNIELLYLGQNCYYRNPCNVSFEIEETAFLNLKNLTVLSLKSNNLTFIPPNLSSTLKELYIYNNRIQEVQEHDLSNLYNLEILDLSGNCPRCYNAPYPCTPCPNISIKIHSKAFYSLKKLRILRLHSNSLQSIPSSWFKNIKNLKNLDLSQNFLIKEIGDAEFLKLIPSLVELDLSFNFELQMYSPFLNLSKTFSCLSNLETLRIKGYVFKELREENLDPLLNLRNLTVLDLGTNFIKIADLRVFKKFRSLKIIDLSMNKISPSSGESNFYGFCSDHRITVEQYSRHVLQEMHYFRYDEYGRSCKSKDKEADSYQPLVNGDCMSYGETLDLSRNNIFFVNSIDFQDLSFLKCLNLSGNAISQTLNGSEFYYLSGLKYLDFSNNRIDLLYSTAFKELKFLEILDLSNNKHYFLAEGVSHVLSFMKNLAYLKKLMMNENEISTSISTGMESQSLQTLEFRGNRLDIFWSDGKKEYLSFFKNLTNLEQLDISSNMLNFLPPDVFEAMPPELKILNLTSNRLHTFNWGKLHLLTKLITLDLSNNLLTTVPRKLSNCTSTLQELILRNNRITRITKYFLRGAIQLTYLDLSSNKIQIIKKSSFPENIINNLRMLLLHNNPFKCNCDAVWFVGWINQTQVAIPLLATDVTCAGPGAHKGRSLVFLDLNTCELDTSYFIMYALSTSAVLCLMMFAVMSHLYFWDVWYSYHYCTAKLKGYRRIPLPDACYDAFIAYDNTDLAVNEWVMTELVEKLEDQKARQFNLCLEERDWLPGQPVFDNLSQSIQLSKKTIFVLTNKYIKSGTFKTTFYMAHQRLLDEKIDVIILIFLEKVLQKSRYVQLRKRLCRSSVLEWPTNPRSQPYFWQRLKNAIAMNNTLSYNKLLQETV
Protein: Male sterile (3) 76Cc (Q9VW23)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI06002p
- Male sterile
- ATP synthase subunit beta
Sequence:
MPISQHDLARFASAPGSCPRISMSNSSNTYLSYSDLDLGSKFCGGGSLRTEPSCDHWKFCEKVPNRSDVEADSLGCPVGLVCSNATVNNPCGCSPKQQEANVLNFATYLKAFALIYVLPETDWTAEKIDMLLEEGTDLFRASSDVNQGHDDPDEHKLLEPEIYTNEEKRIKRNFNLEGHTFTLALEPRYLGVGSKPLDQQPPHIIKNLGTILQSFFKSSRYCLLLTRVGHLLIWRRRRVFFVLDVKGRAKDDLATVKDNGVAMLVCLKSIDNVVHLASNLSGISPRDEFSIRELVVVRLETPDGRIYMRDTSHRSIEFKVVNKSYAYLKGTLHLSLNKDDPVRNRSSLMVAVGSVLASKIDHPANWDTNMLDRLISYGVELCRSCWSDCLRDRRPIDLDTFPTQLRMGQFVLELKLIPNVRTGHWRCGVRIIGTDFEAHVSQALKELGNVVFQINNQMYAIWLKDGFYYLVDPYRHTIVGTHVAEDKAEGAKWATVRMFRDQLTMLSVFHQLLKESNRQSAYYVHVVRIRNLAECPEGYALLPMPDGKDSCEVKSLNETIFFNEQQCVRVCNKSLAEISDYEEDVVSLLTDKSDIDHFQVLDEQQNGGAECEFCEEEFRTEPLKRRPKGKNTNSKSRVGLSKREQDIKDTSGKMLPTASRTPNDKDSPRLDKKSRSANRQAGGRSSSTKSPGLTKSRENTSNRIAKRSVLPSKQTELGTHFPPSKAPVKTTPNVAPPSGRIVRSTIKTREVGGRSSNRSQNNTLGRSRSREEPFPERITTKKMQFKRQAGGMCSRDPLSTSPERCKPREGSSPDRTIKKIVKSSRQTGGTVCSPPPDVSSLRYRSKEDVTPGKIMIKSENTKDSGSPIKSHLRSKSRNRSPGKFSPRGTPSRKMAPKVDDSKGANPALDLSITKEAIRTQVANKEASDRKGVIASKGVMLLRKVNMKTDTAIEPSKKEATQTHILQQSVDKSKSLGVAPLAAAHLNTPAASNFVNELDQKEKPPYPKMNVRNAEQSIEHPKNCCCRDAEEDSMEGIGSRMPVKFPGFSRAPHLLAVAGSESGTVESLNRVLSSAFKVANRVLTMTPWGNYVVFRHHPTNRSAATWFYVFDGCTCDIDRFRHLDLSTGTAGLIAFRKQSEVVCHIIDSREEKALKMLRSGMEDPPHKRIQRLLAR
Protein: Zinc finger protein 428 (Enzyme-like protein PIT13) (Q96B54)
Organism: Homo sapiens (Human)
Interaction partners:
- Ubiquitin-like protein 7
Sequence:
MTETREPAETGGYASLEEDDEDLSPGPEHSSDSEYTLSEPDSEEEEDEEEEEEETTDDPEYDPGYKVKQRLGGGRGGPSRRAPRAAQPPAQPCQLCGRSPLGEAPPGTPPCRLCCPATAPQEAPAPEGRALGEEEEEPPRAGEGRPAGREEEEEEEEEGTYHCTECEDSFDNLGELHGHFMLHARGEV
Protein: P2X purinoceptor (P2X purinoceptor 3) (Q9I8N8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000681}.
Interaction partners:
Sequence:
MAPRVLGFIKGFFVYETAKSVVVKSWSVGIINRIVQLLIILYFICWVFMHEKAHQLRDTGIESAVMTKVKGLGNFNDRVMDVADYVIPSQGASSFSIITNMVVTANQTQGYCPEIEKKFSCTSDGDCEKKIGLNIGNGMITGKCLNDNGTSNDTWRCEIQGWCPAEDDTISGKPMHEVENFTIFIKNSIHFPLFGVARGNFPSSLNKSYIQSCNYDPVRHPFCPIFKVGDILKHLNQSLENITKIGGEIGININWKCNLDYDEENCNPKYFFTRLDAAFEHSSVSKGYNFRFAKYYQSEDGTEYRTLHKAYAIRFEIIVSGNAGKFNVVPFLINLVAAFTSVGLATVFCDIILLNFHKGADEYKAKKFEEVSGNVPESGSNILYKGSQVSIKALEKNSNDSGTFSIGRQE
Protein: Ceramide synthase hyl-1 (HYL-1) (EC 2.3.1.297) (G5ED45)
Organism: Caenorhabditis elegans
Function: Catalyzes the acylation of sphingoid bases to form ceramides. Sphingolipids from Caenorhabditis elegans contain exclusively isosphingoid bases. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative phosphatidylcholine:ceramide cholinephosphotransferase 3
- Sphingosine kinase 1
- Ceramide glucosyltransferase 3
- 3-dehydrosphinganine reductase
- Alkaline ceramidase
- Probable acid ceramidase
- Putative sphingomyelin phosphodiesterase asm-3
- Putative sphingolipid delta
- Putative sphingolipid delta
- Putative neutral sphingomyelinase
Sequence:
MWRMSYFWHEPYWLPRNVTWPEVPAKFVDLLVPIYLAIPLVIIRILWESTIGVTYLYFRTNAYASRKNITLLGCMWEHMTGGFASVSRAKKILECFWRFSYYTFAFLYGLYVMKNSSWLYDVKQCWIGYPFHPVPDTIWWYYMIETGFYYSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRYDAHNKNMTNFMFVLFFSSWVATRLIYYPFIVIRSAVTEAAALIQPDYILWDYQLSPPYAPRLIVFALILLFFLHIFWTFIILRIAYRTSTGGQAKDVRSDSDSDYDEEEMARRERTRLLKKKKNKVSPSTDDDDDEGEEEKNDRKARHRRAPRKE
Protein: Kinesin-like protein (Q9VZF5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Rac GTPase-activating protein 1
- Serine/threonine-protein kinase polo
- Pebble, isoform B
- Inner centromere protein, isoform A
- Anillin
- Protein nessun dorma
- GTPase-activating protein RacGAP84C
- Fascetto
- Aurora kinase B
- Kinesin-like protein Klp61F
Sequence:
MKAVPRTPMRVVPKTPRVHQTVEKQRRDTSDKARDPVNVFCRVRPLQSDADLTSLRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVEPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATPMKQDLGLTPGRRKANKLFKIAVNNLNELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHYLEQRIEKRKKLRANLDIKCDSFRQMLMNLDRDNLQLRTELASLKAVYKQERDRSAALEKKVRIHESSIDVLNNTLSKQERQIEELTFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRVKLQERMRIKDEKLRLVSNILQSEDLPSLPRSQSSENILNEKDRGAYTARTEESSVPATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDLKELTAHGTTKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKRPSNGNISALGGGAVPSTVTSAQDVASRCNLGIEGHSSKKSKI
Protein: Shionone synthase (AtaSHS) (EC 5.4.99.46) (F8WQD0)
Organism: Aster tataricus (Tartarian aster)
Function: Oxidosqualene cyclase involved in the production of shionone, a triterpenoid with a rare 6/6/6/6 tetracyclic skeleton and a C-3 carbonyl carbon. Produces also small amounts of beta-amyrin, friedelin, dammara-20,24-dienol, and 4-epishionone.
Interaction partners:
Sequence:
MWRLKIADGGNNPYLYSTNNFIGRQTWEFDPNYGTPEERDEVEQARLHFWNHRHEIKPSGDTLWRMQFIREKKFKQTIPQVKIEDDEEISYDKVTATMRRSVHLLEALLADDGHWPAENSGPSFFIQPLVMCLYITGHLNSVFPAEHRKEILRYVYSHQNKDGGWGLHMEGHSIMFGTTLSYICMRLLGEGPDGGLNGACTRARKWILDHGGAIANPSWGKVWLSILGVHEWVGCNPLPPEFWLFPSFLPMSPGKMWSYCRLVFMPMSYLYGRRFVGPITPLVLQLRKELYAQPYNDIKWKSSRHVCAKEDIYYPHPLLQDLMWDSLYILTEPLLTRWPFNKLRKKALATTMRHIHYEDENSRYITIGSVEKILCMLACWDEDPNGVCFKKHLARIPDYIWVAEDGMKMQTFGSQVWDASIGIQALLATELTHDIAPILKKGHEFIKASQVRDNPSGDFKSMYRHISKGSWTFSDQDHGWQLSDCTTIGLTCCLLLSTMPPETVGEKMDPEQLKDAVNVILSLQSENGGLAAWEPAGSSNWLEMLNPIEFIEDIVIEHEYVECTGTGMEALVLFKKLYPKHRTKEVESFLTNAARYLDNTQMPDGSWYGEWGICFTYGTYYALGGLAAIEKTYENCQSIRKAVRFLLKTQGEDGGWGESYRSCAEKIYIPLDGNRSTVVHTAWAMLGLMHSKQEERDPIPLHRAAKLLINSQMENGDFPQQDTTGAFKKNCLLHYPMYRNIYTLWALAQYRKKVLRQPTGI
Protein: Interferon-related developmental regulator family protein / IFRD protein family (F4HUS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Coiled-coil protein
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31x fusion protein
- Large ribosomal subunit protein eL38z/eL38y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
Sequence:
MGRKSQRKNATMFDSDDDTSSVSSSSTMPSERLLNPGMDEVTVLKDALLDQSLDALYEKRSSTREQALATIVDAFNSDLQYEFVEKKFATLLHQCLHCTKKGSTKETSLATHVIGLLALTVGLGDHAQEVLEESVTPLSQALKSGREILKITSILECLAVITFVGGNDPEQTEKSMQIIWQMIHPKLGSNVVATKPSPAVISAVVSSWAFLLTTVDRWTLGPKIFQETVTYLSTLLEKDDRSVRIAAGEALAVIYELGTLEKFAAEVKGSANGSVKEGGVSQEALMHMHGLKAKVTKQVRELSVEAGGKGSAKKDLNTQRNLFKDLVEFLEDGYAPETSTKVGGDYLQTSTWYQMIQLNYLKHFLGGGFIKHMQENEFLHDVFSFTPKKIGGGKLSNDEKRLFKSPNSALNKARTQFLAKQRMLAKNMNVGHYAATAMEEE