wanglab/gogpt-training-data huggingface dataset:
Protein: Laccase-11 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 11) (Diphenol oxidase 11) (Urishiol oxidase 11) (Q8VZA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lignin degradation and detoxification of lignin-derived products.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Phenylalanine ammonia-lyase 1
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- Phenylalanine ammonia-lyase 4
- Phenylalanine ammonia-lyase 2
- Phenylalanine ammonia-lyase 3
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Probable caffeoyl-CoA O-methyltransferase At4g26220
- Trans-cinnamate 4-monooxygenase
- Cytochrome P450 84A1
Sequence:
MKMGFLFLFCYLLAFLGYSPVDAAVKKYQFDVQVKNISRICNAKPIVTVNGMFPGPTVYAREGDRVIINVTNHVQYNMSIHWHGLKQYRNGWADGPAYITQCPIQTGQSYLYDFNVTGQRGTLWWHAHILWLRATVYGAIVILPAPGKPYPFPQPYQESNIILGEWWNKDVETAVNQANQLGAPPPMSDAHTINGKPGPLFPCSEKHTFVIEAEAGKTYLLRIINAALNDELFFGIAGHNMTVVEIDAVYTKPFTTKAILLGPGQTTNVLVKTDRSPNRYFMAASPFMDAPVSVDNKTVTAILQYKGVPNTVLPILPKLPLPNDTSFALDYNGKLKSLNTPNFPALVPLKVDRRLFYTIGLGINACPTCVNGTNLAASINNITFIMPKTALLKAHYSNISGVFRTDFPDRPPKAFNYTGVPLTANLGTSTGTRLSRVKFNTTIELVLQDTNLLTVESHPFHLHGYNFFVVGTGVGNFDPKKDPAKFNLVDPPERNTVGVPTGGWAAIRFRADNPGVWFMHCHLEVHTMWGLKMAFVVENGETPELSVLPPPKDYPSC
Protein: Collagen type XIV alpha 1 chain (F1S285)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MKIFQCKMQYWLFPAFLAVTYFCTIVQGQVAPPTRLRYNVLSHDSIQISWKAPRGKFGGYKLLVTPAAGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYHKDKESKPAQGQFRIKDIEKRKEPKPRVKVVDRDGNKPSTPEEEVKFFCQTPAIADIVILVDGSWSIGRFNFRLVRSFLENLVTAFNVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGARTGVSKIGILITDGKSQDDVIPPSRNLRESGVELFAIGVKNADENELREIASEPDNTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDREIKASALAAIGPPTELLTSEVTARSFMVNWTHAPGKVEKYRVVYYPTRGGKPEEVVVDGSISSTVLKNLMSLTEYQIAVFAIYAHTASEGLRGTETTLALPIASDLELYDVTENSLRARWNPVAGASGYLILYAPLTEGLAGDEKEMKIGETHTDIELRGLLPNTEYTVTVYAMFGEEASDPVTGQETTLPLSPPRNLRISNVGSNSARLAWDPTSRRISGYRIVYNNADGTEINEVEVDPITTFPLKGLTPITEYTVAIFSIYDEGQSEPLTGIFSTEEVPAQQYLEIDEVMTDSFRVTWHPLSADEGQHKLMWIPVYGGKTQEVVLKEDQDSYVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLFRTGIRNLVVDDETTSSLRVKWDISDSSVQQFRVTYLTAQGDPAEEVVGTVMVSGNQNDLLLKNLLSNTEYKVTVTPIYDDGEGVSVSAPGKTLPPSGPQNLRVSEEWYNRLRITWDPPSSPVKGYRIVYKPVSVAGPTLETFVGANINTILITNLLSGMDYNVKIFASQASGFSDALTGVVKTLFLGVTDLQADQIQMTSLCARWQVQRHATAYRIVIESLQDTQKQESTLGGGTTRHCFYGLQPDSQYKISVYTKLQEMEGPSVSIMEKTKSLPTPPPTFPPTIPPAKEVCKAAKADLVFMVDGSWSIGDENFNKITNFLYSTVGALDKIGADGTQVAMVQFTDDPRTEFKLNTYKTKETLLDAIKHISYKGGNTKTGKAIKHVRDNLFTAESGIRRGIPKVIVVITDGRSQDDVNKISKEMQLDGYSIFAVGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVCETASATCPLVHKDGIDLAGFKMMELFGLVEKDFSSVEGVSMEPGTFNVYPCYHLHKDALVSQPTKYLHPEGLPSDYTISFLFRVLPDTPEEPFALWEILNKNSDPLVGVILDNGGKTLTYFNYDYSGDFQTVTFEGPEIRKIFYGSFHKLHIIVSKTMAKVVIDCKEVGEKAINASSNITSDGVEVLGRMVRSRGPNGNSAPFQLQMFDIVCSTSWANKDKCCELPGLRDEETCPELPHSCSCSEINKGALGPAGPPGGPGLRGPKGQRGEPGPKGPDGPRGETGPPGHQGPPGPQGPSGLSIQGMPGMPGEKGEKGETGLPGPQGIPGSVGSPGRDGSPGQRGFPGKDGSSGPPGPPGPIGIPGAPGVPGITGSMGPQGALGPPGAPGAKGERGERGDLQSQAMVRAVARQVCEQLIQSHMARYTAILNQIPSHSSSIRTIQGPPGEPGRPGSPGAPGEQGPPGSPGFPGNAGVPGTPGERGLTGVKGEKGNPGIGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVGDLIPYNDYQH
Protein: Ankyrin (P97582)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAYIQAITESGLTPIPVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGEVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLVLEKGANIHMSTKSGLTSLHLAAEEDKVNVADILTKHGADQDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNAPETMTEVLDVSDEEGDDTVTGDGGEYLRPEDLKELGDDSLPSS
Protein: GEO08227p1 (Niemann-Pick type C-2h, isoform A) (Niemann-Pick type C-2h, isoform C) (RH04252p) (Q9VA41)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Niemann-Pick type C-2c
- Niemann-Pick type C-2e
- NPC intracellular cholesterol transporter 2 homolog a
- GEO07678p1
- Niemann-Pick type C-2g, isoform A
- Niemann-Pick type C-1a, isoform A
- NPC intracellular cholesterol transporter 1 homolog 1b
- Niemann-Pick type C-2d
- LP08842p
Sequence:
MLRLSSLLPVAFALVLSSVSAEIVNFQTCEDSVDSCSISQVRVTPCPEANANAACHIRRRHRFTMSFDFTPHFDADTLVASLGWAKSENVELPLLTMDQEACKYTTCPVRSGVTQTYTNNMPADARFPLSPYTIRWALKDPVSQKRCCFTIDIKVVR
Protein: Probable serine/threonine-protein kinase ifkA (EC 2.7.11.1) (Initiation factor kinase A) (Q558U1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
- Probable histidine--tRNA ligase, mitochondrial
- Probable basic-leucine zipper transcription factor R
Sequence:
MAPGEIIIFELCQAVQEFLLLYNKETVSLHEEMIKRLNTNINRVNSSDDINNNNNNNNDDDDDNDDYDDSDDENSDSDYDDYDDSDDENSDDEFYSDDEDYNTRHQMGDIGSSVNKIINSIDHTISHGGGVGVGIGSGNGLFSKSSSSSSPMIPYNFSFDSLNGFDPDIIFEDSFQTPLKGSSSIDFEEMNNLTNSNNSNSTATTTTTTTTNNNNNNNTNNNNNNNSNNNNNNNNNNNNTNNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNISNNKINKINNNNNNKELIDNNNNNKDKENDLINDTIPKIKWKKGSCIERKSNYSVYRGVDEDTDRKLICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQKEIESMKYLGNPYIIKYLGTNFQEGQNTLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIFFNQSTSKMLLSNYGGRNIKIFDHFEKLNSLKNLNSWISSTNNSINNINNINNNNNNNNNNINTTTTQNQINNEIDRREDIINLGIVVLEMLCGSDLANNQTVLIYLAQLNLLNNQQQNQNFIQPPPLQYQLQQQYDLIKEIEQKTHPSSPISNNAKDFLSLCFTINGNGSTNDSLEAGILLKHPFLASNSNSTPPPSNFLNFTNNIKFLDQRSAATQALLSSPHSLIPQPIQTLIKSQTPNNNNDNNNLASSNELLSSSNGSNIDLRSTNSSIVSNPLATSSSLDNITPPPSRPISPKPSPLNKRNQKLQTSQQKPPLSPPQTPLKQIPQSPQSPPQQNFNTPPTTTTTTTTPTATPTTPTMTPLTPIQKQQQIDYDMFRYHSRYRTDFEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLLPSKMEDDILKEAIKTIANPTISLFSYLMEKLFCLSNDEHIMSRYLYTSNPSLTPMHLICREKTFSRLEKIFLNHGSIRIDTPTLFPKNPTNSTHPGAANVAKFLDESGTVVYLPYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKELYECDFDIIGPSKSRHISDAETLRIIIEIMEEFKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSILSECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKEHGLSASIVSNISTYFRQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYYEGLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIVSGVGVTLACEKIVNSVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFVCSLGSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSRKHNVDSKNIIQNTSSSDLSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSNQSTSSSGNSNNSNTQQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSSSNIIHFDEPTDSFSTQIVYQGVEEIKKSKIETLVQTSLSKLFRGFIQSKSSTIRVIVTDLAYSVIRDLQISESHDNISKFQRVSKEKLLQLKNQIFKWKVYPFIVIHSIKDDKSVIFNSVV
Protein: H19 imprinted maternally expressed transcript (A0A8I6A0U9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTWSGVMERTEGQSSSLPDSVLCRTPWAGAVGHCRRSRLFFPLPKELTHLCCSLDPLPPTLNPQDERNGATQLMSGPLNPGTSLSPSSSESRICCTQNHYTTCLRNRLEGKAEGTDGDNILKEQTHTAPTHP
Protein: Ubiquitin-conjugating enzyme E2 1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 1) (Ubiquitin carrier protein 1) (Ubiquitin-protein ligase 1) (P52478)
Organism: Caenorhabditis elegans
Function: Catalyzes the covalent attachment of ubiquitin to other proteins.
Interaction partners:
- E3 ubiquitin-protein ligase bre-1
- E3 ubiquitin-protein ligase ubr-1
- E1 ubiquitin-activating enzyme
- Ubiquitin-conjugating enzyme E2 13
- UBiquitin Conjugating enzyme
- Ubiquitin-conjugating enzyme E2 variant 1
- Polyubiquitin-A
- RING-box protein 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-conjugating enzyme E2 25
Sequence:
MTTPSRRRLMRDFKKLQEDPPAGVSGAPTEDNILTWEAIIFGPQETPFEDGTFKLSLEFTEEYPNKPPTVKFISKMFHPNVYADGSICLDILQNRWSPTYDVAAILTSIQSLLDEPNPNSPANSLAAQLYQENRREYEKRVQQIVEQSWLNFGENEGDAVLKDDVEIEEIAAPGANDADDDRMDEGASGSNA
Protein: X-linked lymphocyte-regulated 4B (B1B0R4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MASKIKGRPPKQPKVTPALPSNDSQQLHENNPGNNLALETCGESSSSHGTGGPKPGPSKKTLNERKRKYGVSVNKTVQNIEWNVDHFLKVQHERRQELYKDYSHQFLTLVMMWNIDVDQIKKQAGKLSDILDEQQKLFQQFQSIHMQKIEEFKELCDRHL
Protein: Zinc finger protein 521 (J3QQI2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDSKTKDL
Protein: Probable rhamnogalacturonase A (RGase A) (RHG A) (EC 3.2.1.171) (A2QYE5)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MPALPILALALAPLLVNGQLSGSVGPLTSAHSKAATKTCNVLDYGAVADNSTDIGSALSEAWDACSDGGLIYIPPGDYAMDTWVSLSGGKATAIILDGTIYRTGTDGGNMILVENSSDFELYSNSSSGAVQGFGYVYHREGDLDGPRILRLQDVSNFAVHDIILVDAPAFHFVMDDCSDGEVYNMAIRGGNSGGLDGIDVWGSNIWVHDVEVTNKDECVTVKSPANNILVESIYCNWSGGCAMGSLGADTDITDILYRNVYTWSSNQMYMIKSNGGSGTVNNTVLENFIGHGNAYSLDVDSYWSSMTAVDGDGVQLSNITFKNWKGTEADGAERGPIKVVCSDTAPCTDITIEDFAMWTESGDEQTYTCESAYGDGFCLEDSDSTTSYTTTQTVTTAPSGYSATTMAADLTTDFGTTASIPIPTIPTSFYPGLTAISPLASAATTA
Protein: Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Serine protease 14) (A5PMY0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 11
- Coagulation factor II
Sequence:
MDPMDGGMRYTPGSTDKDWDQAVTFLPASDHKKMEKKKGPGKIGIIVGLVILAAVLALIIGLVVWHFHFRNDLKLQKIYTGSFRITNEAFVDAYENPQSPEFQNLADKVSTQLKLMYSESSQLSKYYVTSRVQAFSEGSVIAYYESEFAVPAAHEAAVDQAVSNLSEKYSSGKARKVSEQQGSLVLDSVVSSALDKRLISKARSSTRYNKHTSRFVEDIIFSPGFPDSPYPSNTFVQWQLRGDPDHVLKLTFDTFNLEQNCSNDFLRVYDSLVALDKFIMAEKCGYYSPSDPLSFISSRNVMLVTLVTNEEGAYPGFRARVSQIQAVTCGGRMIGNSGIFTSPNFPDYYPPNITCQWYIEVPAGKFIKLKFPKIMVSTGSECHGDFVEVVGQSKLCGQQLNTIVTVNSNTATVRFVSDSSNVDRGFSATFEDYSPSDPCQDLFLCNNKRCVKPSMRCDGWNDCGDTSDEQNCQCDAKMIQCKNGLCKPMFWRCDGVDDCGDSTDELNCGCRADQFKCKNDKCISEKQKCDGKDDCNDGSDEEGCARTDSCLVSTFLCGNSKCITKPNPECDGQDDCGDNSDESNCNCGTKAYKKSRIVGGQDAFEGEFPWQVSLHIKNIAHVCGGSIINERWIVTAAHCVQDDVKIKYSQPGTWEVFLGLHSQKDKLTATKRLLKQVIPHPYYNAYTYDNDIALMEMESPVTFSDTIRPVCLPTATDTFPAGTSVFISGWGATREGGSGATVLQKAEVRIINSTVCNQLMGGQITSRMTCAGVLSGGVDACQGDSGGPLSFPSGKRMFLAGVVSWGDGCARRNKPGIYSNVPKFRAWIKEKTGV
Protein: Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5) (Q9WVA3)
Organism: Mus musculus (Mouse)
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis.
Subcellular location: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19888327}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
Interaction partners:
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Cell division cycle protein 20 homolog
- Cell division cycle protein 27 homolog
- Mitotic spindle assembly checkpoint protein MAD2A
- BUB3-interacting and GLEBS motif-containing protein ZNF207
- Anaphase-promoting complex subunit 4
- Mitotic spindle assembly checkpoint protein MAD1
- Cell division cycle protein 23 homolog
- Cyclin-dependent kinase 1
Sequence:
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKST
Protein: Dehydrogenase orsE (EC 1.-.-.-) (Enoyl reductase orsE) (Orsellinic acid/F9775 biosynthesis cluster protein E) (Q5AUW6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Dehydrogenase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B.
Interaction partners:
Sequence:
MATNQAAWLTKAGNDLEVGDAPVPTAGPGEIVVKNAAVAINPLDTHMQDVGVFVQQWPTIFGCDVAGTVHETGPDVERFKKGDRVIGHAINLVTGRPQDGAYALYTVVPANKAAILPDAISFTDGVVAPFAVEAAVCVLSLKEPGVAMPGVSTPALALPYPSLDDPVKPLGKVLVIWGGSSSVGSMTTQIATAAGIQVIAISGAHNFELSKRCGATEVFDHKDPEVVDKVVAAVQKSGQEFVGIFDAVATPDTYTSDLVILEKLGGGHLAAVHPPPAEVPSNVKAGMIFAVNDIATPVWNDFVTPALESGKIQCLPPPTIVGKGLEAINEGLKRCKAGVSATKLVVEL
Protein: Alpha/beta-glucosidase agdC (G5EB11)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Alpha-glucosidase
- Glucoamylase
- Glucoamylase
- Alpha-glucosidase
- Hexokinase
- Phosphotransferase
- Phosphotransferase
- Probable alpha/beta-glucosidase agdC
- Glycosyl hydrolases family 32 superfamily
- Alpha/beta-glucosidase agdC
Sequence:
MRFQQLLPWAAALTGCVVAQSQAGVDPLDRPGNDLYVKDLSNCTGYKVTKHWKTRSGFYADLALAGPACNVYGIDLPKLKLEVEYQTDERLHVKILDTNNTVYQVPDSVFPRPGFGQWCSPKNSKLKFDFKPDPFSFTVSRTDTGEVLFDTTGTKLVFENQYLYLKTHLPQNPHLYGLGEHSDSFMLNTTNYTRTIYTRDAYGTPQGQNLYGAHPIYFDHRQDGTHGVFLLNSNGMDIYIDNEGGQFLEYNIIGGVFDFYFIAGPSPQDVARQYAEIVQPPLMVPYWGLGFHQCRYGYQDVYEVAAVTANYSVHDIPLETIWTDIDYMDRRRIFTLDPERFPPELVKDLVDTLHARDQHYIVMVDPAVYYSEPNPALDAGLKYDAFMKELNGTHYQGVVWAGPSYFPDWFHPNAQEYWTEQFLNFFDGVNGPDIDALWIDMNEPANFYNRPYPGNNTTPEEFAEANDNPPEPPAVRDGPDAPIPGFPDSLQPNFASGQTNEKRAVVTVERRARSQSHRQLGAGRWRSAVRHWPRDPKAGWQHGRKSGSGCGPHECRGLPNRELIRPPYMIQNGAGPTLADNTADTDIVQSGGYVQYDTHSLYGAMMSTHSHNAMRARRPDDRALVITRSTFAGSGKDVSHWLGDNISDWLSYRLSISQILQFASLYQIPVVGPDVCGFGGNVTETLCARWATLGSFYTFFRNHAEIFANPQEFYRWPIVAEAARNGIAIRYQLLDYIYTAIYKQTQTGTPSLNPLFFNYPFDQNTYGIDLQFFYGPGILVSPVTEENSTSVSYYLPDDIFYEWGTGKPVRGHGEYVSAEVDVTHITVHYKGGLVYPQRIESANTTTALRQKGFNIVIAPGLDGSAHGELYLDDGLSQVQDKVSEIDFSYVDGVFEMKGSFEYDPGVGIERITILGVGAKPEVAAEDAEVEYDEENQKLVLHVDVPLTRKSSIKIA
Protein: Voltage-gated potassium channel KCNC1 (NGK2) (Potassium voltage-gated channel subfamily C member 1) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) (P15388)
Organism: Mus musculus (Mouse)
Function: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1400413, ECO:0000269|PubMed:2599109}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P25122}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P25122}. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. {ECO:0000250|UniProtKB:P25122}.
Interaction partners:
- A-type potassium channel modulatory protein KCNIP1
- Calsenilin
- Voltage-gated potassium channel subunit beta-1
- A-type potassium channel modulatory protein KCNIP2
- A-type potassium channel modulatory protein DPP6
- Voltage-gated potassium channel subunit beta-2
- Ubiquitin-like protein FUBI
- Kv channel-interacting protein 4
- Inactive dipeptidyl peptidase 10
- Voltage-gated potassium channel subunit beta-3
Sequence:
MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI
Protein: Ubiquitin thioesterase OTU (EC 3.4.19.12) (Q38A95)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU367104}.
Interaction partners:
- Ubiquitin fusion degradation protein, putative
- Guanine nucleotide-binding protein subunit beta-like protein
- MPN domain-containing protein
- Ubiquitin fusion degradation protein 2, putative
- Polyubiquitin, putative
- SEP domain-containing protein
- UBX domain-containing protein 11
- Valosin-containing protein homolog, putative
- AAA ATPase, putative
- ATPase, putative
Sequence:
MLRFRVRLPKGKEPVSMDLDGTTTWGSFVQSISSLTDVPCSQLRILSGFPPRPVEVGDGAASIASVLPGGGNVIVQVGEADVVKGKTEGRYVPPVDGKWHFVRRVCPSDNSCLFHAAAYVLRNKSRVDGPSLRKECADIVQAYPNVFNEKTILDRPNREYVDFIRNPNAWGGAIELMVLSFLTQTEIVALDLTSSNVLHFGEDNNYTVRAYVVFNGQHYDAIAMNPMFNSPQESEDQVLFSSTDAEVLNRARRFVADEAKKLRLR
Protein: Laminin subunit alpha 3 (A0A3B3ITG1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
Sequence:
IPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPTALILDVLSGRPFPHLPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLGRYVFVIHFYQAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRDQVIAEGQIEFDISEPEVAATVKVPEGKSLVLVRVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADRVDIPVSFNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVEPCRRRKEESDKNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIKIGKLQKRMWINVDVQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGGPIFKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISSSRQSLRLGGSNFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLMLLKGSTRFNKTKTFRINQLLQDTPVASPRSVKVWQDACSPLPKTQANHGALQFGDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTGTKNSFMALYLSKGRLVFALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAPVYLGSPPSGKPKSLPTNSFVGCLKNFQLDSKPLYTPSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQPGKHLCVYLEAGKVTASMDSGAGGTSTSVTPKQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAGQIPFPPASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNHIPVPVTEALEVQGPVSLNGCPDQ
Protein: Protein STRUBBELIG-RECEPTOR FAMILY 7 (Leucine-rich repeat receptor kinase-like protein SRF7) (Q9LUL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein MEI2-like 3
- Leucine-rich repeat protein kinase family protein
Sequence:
MTENRVVLALLILCIVGFEPSFIHGATDSSDTSALNIMFSSMNSPGQLSQWTASGGDPCGQNWKGITCSGSRVTQIKLPSLGLSGSLGFMLDKLTSVTEFDMSNNNLGGDLPYQLPPNLERLNLANNQFTGSAQYSISMMAPLKYLNLAHNQLKQLAIDFTKLTSLSILDLSSNAFIGSLPNTCSSLTSAKSIYLQNNQFSGTIDILATLPLENLNIANNRFTGWIPDSLKGINLQKDGNLLNSGPAPPPPPGTPPISKSSPTPKSGNRGNRSNGDSSNSKDSSKSGLGAGGVAGIVISLIVVTAVIAFFLIKRKRSKRSSSTDIEKTDNNINQPIILASNDFHQENKSVQNPPLVETKKLDTSLSMNLRPPPSERHKSFDDDDSTMRKPIVAKKAAVVVPSNVNTYTVSDLQVATNSFSVDNLLGEGTFGRVYRAQFEDGKVLAVKKIDSSALPTDTADDFTEIVSKIAHLDHENVTKLDGYCSEHGQHLVVYEFHRNGSLHDFLHLAEEESKPLIWNPRVKIALGTARALEYLHEVCSPSIVHKNIKSANILLDSELNPHLSDSGLASFLPTANELLNQNDEGYSAPETSMSGQYSLKSDVYSFGVVMLELLTGRKPFDSTRSRSEQSLVRWATPQLHDIDALGKMVDPALKGLYPVKSLSRFADVIALCVQPEPEFRPPMSEVVQALVVLVQRANMSKRTVGVGSGSSGVNDYM
Protein: Integrin subunit beta 1 binding protein 2 (A0A8I6A523)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPATSSLQEQKPLNTIPKSAETLLRERPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPASCRHDWHQTDSLVVLTVYGQIPLPAFNWVKASQTEVINVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDLSWTEEEDEDEEEAMGE
Protein: Ferric uptake regulation protein (A0A0H3C2M1)
Organism: Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU364037}.
Interaction partners:
Sequence:
MDRLEKACIEKGMRMTDQRRVIARVLSSAEDHPDVEELHRRAHAIDPHISIATVYRTVRLFEESGIIERHDFRDGRSRYEQSPDHHHDHLIDMKTGKVVEFVDEEIEALQHAIAKKLGYKLIDHRLELYGMPLEE
Protein: Large ribosomal subunit protein uL3 (50S ribosomal protein L3) (P9WH87)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Interaction partners:
- Large ribosomal subunit protein bL25
- Large ribosomal subunit protein bL33B
- Uncharacterized protein Rv0500B
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein bL27
- Large ribosomal subunit protein bL31
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein bL17
Sequence:
MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK