Protein: Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1) (P27884)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O00555}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit beta-1
- GCF C-terminal domain-containing protein
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Ryanodine receptor 1
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent N-type calcium channel subunit alpha-1B
Sequence:
MARFGDEMPARYGGGGAGAAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAVNQKLALQKAKEVAEVSPLSAANMSIAMKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYSEMDPEERWKASYARHLRPDMKTHLDRPLVVDPQENRNNNTNKSRVAEPTVDQRLGQQRAEDFLRKQARHHDRARDPSAHAAAGLDARRPWAGSQEAELSREGPYGRESDHQAREGGLEPPGFWEGEAERGKAGDPHRRHAHRQGVGGSGGSRSGSPRTGTADGEPRRHRVHRRPGEDGPDDKAERRGRHREGSRPARSGEGEAEGPDGGGGGGGERRRRHRHGPPPAYDPDARRDDRERRHRRRKDTQGSGVPVSGPNLSTTRPIQQDLSRQEPPLAEDMDNLKNSRLATAEPVSPHENLSHAGLPQSPAKMGSSTDPAGPTPATAANPQNSTASRRTPNNPGNPSNPGPPKTPENSLIVTNPSTAQTNSAKTARKPDHTTVEIPPACPPPLNHTVVQVNKNANPDPLPKKEDEKKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMLYRDMYAMLRHMPPPLGLGKNCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPPDEGGAGQNALPSTQLDPAGGLMAHEDGLKDSPSWVTQRAQEMFQKTGTWSPERAPPADMADSQPKPQSVEMREMSQDGYSDSEHCLPMEGQARAASMPRLPAENQRRRGRPRGSDLSTICDTSPMKRSASVLGPKASRRLDDYSLERVPPEENQRHHPRRRERAHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSREREQERGRPKDRKHRPHHHHHHHHHPGRGPGRVSPGVSARRRRRGPVARVRPARAPALAHARARARAPARLLPELRLRRARRPRPRQRRRPRRRRGGGGRALRRAPGPREPLAQDSPGRGPSVCLARAARPAGPQRLLPGPRTGQAPRARLPQKPARSVQRERRGLVLSPPPPPPGELAPRAHPARTPRPGPGDSRSRRGGRRWTASAGKGGGGPRASAPSP