Protein: Cadherin EGF LAG seven-pass G-type receptor fmi-1 (Protein flamingo homolog) (G5EDK5)
Organism: Caenorhabditis elegans
Function: During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation. Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve ring. Promotes motorneuron development by positively regulating the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord. Plays a role in synaptogenesis by regulating synaptic vesicle accumulation at GABAergic and cholinergic neuromuscular junctions.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:20876647}. Cell projection, dendrite {ECO:0000269|PubMed:20876647}. Note=In embryos, localizes to axons in the nerve ring, the tail and along dendrites of sensory neurons. {ECO:0000269|PubMed:20876647}.
Interaction partners:
- Vang-like protein
- LIM zinc-binding domain-containing protein
- DiSHevelled related
- Frizzled-4
- Segment polarity protein dishevelled homolog mig-5
- Plexin-2
- GPS domain-containing protein
- Protein Wnt
- Cadherin-4
Sequence:
MMLDRIMFLLFFILSLVIGSFSEYLDDKYYSTNSIDVVCKPCAVPSSNSVIWLPASRPPCLHPGQPIIHWPDLSDNLACPVPGLPDSVHSSQISLLEGEGLLLTKERICFFDGPIDFHYDYVCDGKLYRSKMRIGHSIASKKKLETRRTKRWARRRNPDANAVHFQQEKYVKELPEDTPIETIIASVKASHASSQPLYYSMVAPQDSRSQNLFTLDTMSGEIRLAKSMDREVLDKHILKVTAYERVDPTISASTTVVVHVLDVQDNSPIFEKDSYFGEIREDAPIGTTVLSVFARDLDSGENGEIEYSLGEGNGKNLLAINAKSGVIQTAAPLDRETLSLIRLDVIASDKGTPKRESTAMVEITVVDVNDNAPVFASDSYNVTILENITIPAVIATVKATDEDFGTNGKVHYSMASSSGIGGLTIDYSTGEVTLRERIDAKNSPITAVIRAKDGAQPALSSTVPLTINVIDINDHAPTLIAAQKMITLEENVAIGEEVGRVYAIDEDSGPNGIIKYSMEGSEDFIIDEDSGLIKTTKLLDRETTARYSLKVTARDMGTPSLNTSTTIAVVLKDINDNAPTFDKKEYNVTISEEMPRGSQIITLKAVDNDEDQKITYRIEEADREVFSILDIGDQGAILSVSGELKRQDHKVRVEISATDQGGLQGRCVVNVFIDDVNSAPYFNDHPFSVKIPEHSPIGYPVITLKAEDHDRGDNARIVYSIDSSQFFRIDPSSGDISVSSDLDREDRATFSVIVTASDHASPPLNTSTQIEVILDDINDNSPQFTSSSYAATISEDIPVGTSFLQVSAIDADIGPNGIVDYFLNESSSSPSIQLFRLDRTSGTLRVSSKLDREQFAVIVLPIFARDRGTPSLSAASEITLTLSDVNDNAPTFEQLSYDLYIAENSPVGSTVGTIVARDADEGDNADISFRIFGGADAKLFDIEEDAEQNGVVRILTRAEFDYEAKANKFFFELQASSGQLSSTVPVRIHVSDVNDNKPALKDFVILMNRFDNVQMARQIGFIPAFDPDQNATLEYFLEENDLIEAEKYTGKILVKQEWKRNMDVSFKTCVSDGANTECSTCRFIHVLVEPEWLSESFTLSLARMTVDDFWDPLVFQRFRDAMSTLSNWKPSDIHVIGVKQHLDDVIYINIAITDHGRVVRGWRAIELVKESIKKLEKMTLLQVEVIRDESCANEPCSHMAKCRQTQKFVGEMKAHETDNFIARTLNTVNTFVCECPSGFTSSGAHGDCDTRIDECYRGRCSNNSTCVAFENTYQCECKPGWIGRHCEISVHALTCVPGYCMSDSLCELDGNQMKCRHCKYHGEDTDERCRLRSVSFDGEGLLNVNLDLPRTQWTMKFRVSTIAHNGVLVFTGDKRSDFVEVSVVDRVLKVQFSLGGEKIDAKMENDVENRINDGEWHTVALEYSNKQITMSLDDCETNPSLLLNTSPNCAIRAKLNLEKKCEDPTVPCYRYLDISNGLFLGGRPGTSKQIEKAFSGCISDLSVDKEDVDFSTIKEMHKVGQVHEGCKHRKDFCSTSDGQCSATSKCVNRWGGRICSCPQSVHSTGECVGALGTQDLRGHSLFEEESFVLYQPSQVSVPFEVSFEFRTSRADMQVFALEFTQRSVHYNLEVDDGTLKYNIGDSEVELPAPEVTSKHWMNVVIKFEADSVATSINGIYSAEAKASISDMNLESLYFGIAPGTGHPSRFEGCIRNVLVDGRSISVKKKGKTRAGCVVPNRCSVDSICPAESTCHRAWNKHKCKCHKSFVGDTCLPVCSVANVCSSGTCVSSNTTAGYECICPAGKTGKNCQLEAPKQMCPSGWWGTFPRCRRCSCAQTKDYEAQCDKKTGACQCKKSHFSTINGCVKCECGFGADSTECSADGHCKCNGDAVGRRCDRCSRFDHQLDSKTLKCRPVSGKCPSEIEYSIQWPASQKGSIVRQSCPVGESGLATRKCLETGRWSDVNAWNCTRPEYSIMVNKFEILEPSKLLTMVANATNTESSIRGRNQQIAAEALSRLVDYEQSMPMKGRAHIKDMKFTEKLIESLGRVMSEQPADEYSTLISKLWNYAETVAEIHENVNFLSPFFVANDHIVFASDKLDFGNILPKFNNFVDLRPTGFPRVRAIVTGTTQVVYSIVPYPRCNRCENPMIAIVANTSDPVIVEFEIEEDDGWKYPECVRFDEKSGTWTARGAALIGLNLTHAACEYNRIGVFTMFVNDQSSSIVRVAQMDNMTSPAIAGVALFLCFLSILLTLSRRSLKTHSVRIGFILFFAINILNLFFVHKTAINQAYCPVRNAMLSFTSSAPFAWLFLYGLYIYRMLADGSSSPSLTTSLLVGIVFPCLISFTTFFVTDQCSLSPHLWLFWCIILPIGLFLLLSFYAAATSVLVSLHKKYDVFVAKYNVKRAVFQHFILTIFTLGMTLTGLFANQLPLPMEIMEISQSIIYLIAALVIFLWCVCDITTKASDSNPSMWLDNQKSVMAESTMADPQCASPLLSPRHQHHEVPMDSEWVPDVNPSNHYHTSINEPDTPRRLLLPQNRDVINILSSPDQILNEGVGHVYRNNMGSLPRLRSAQDEADDAYYTYTASRKYKNTTSTFNRE