wanglab/gogpt-training-data huggingface dataset:
Protein: Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) (Q8N4C8)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:18930710}. Postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus.
Interaction partners:
- Striatin
- cAMP-regulated phosphoprotein 19
- Alpha-endosulfine
- Mitogen-activated protein kinase kinase kinase kinase 4
- Acetylcholine receptor subunit epsilon
- SH2/SH3 adapter protein NCK1
- Striatin-4
- MOB-like protein phocein
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- TRAF2 and NCK-interacting protein kinase
Sequence:
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Protein: Protein lin-37 homolog (Antolefinin) (Q96GY3)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein lin-9 homolog
- Histone-binding protein RBBP4
- Myb-related protein B
- Protein lin-54 homolog
- Protein lin-52 homolog
- Transcription factor E2F4
- Retinoblastoma-like protein 2
- Transcription factor E2F5
- Myb-related protein A
- Transcription factor Dp-2
Sequence:
MFPVKVKVEKSELEMAKARNQLDAVLQCLLEKSHMDRERLDEEAGKTPSDTHNKDCSIAATGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPSVRERECSPSSPLPPLPEDEEGSEVTNSKSRDVYKLPPPTPPGPPGDACRSRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYERQ
Protein: Uncharacterized protein (Q584R8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLSITRCIRGSFILNARVVPDWWQPFHREERHRTAVARIAHLRSSTADGAAVTRESEREAVPITLQEANELVDTYTRNHNAEDLSLVLQHIRETLQESLDSFHYQSLFRVFNYTRDKDNVEQLLLMMVQRGEVDAAVFARIIDTFHCLSPVNVLSSILRVFAAAQDALGNEICGADGCPLLTSVLHHVANSSDYPPTASLLVVVWMRALGVQLCDWDYVHIFAVLLSHADAFPRVRSTIAVFNDFPRGEVSPQALFQRLEDRGELSPASGPLSLLVEAMRSSLQLAGVPLETPVKTCVVNTRTAGLSAIIEFVVDDMASAAAEGKLMGNLLHCYHALALLQSTLRNNTAAVETLHRVAREVKRRESTLEKGTDHASLAASSECVHHHYLIDMGTLLQRVSAHTLQGVRVDYAKSAQSASSDVSQNDIVAAESYAIVFVRSNDEAREALRQVTESVDLTHHRTRLQTKLMFRRFVELCARHPKKNCKMTPTGLEERRKWGRYLDARDTSLALFGSAKQARDSMKHLFYNDNKMPELRSPAIIERDMNDTAALFKWKRAPTVASLRQRTSVPHVQCSSHAVPRHLWDPNVYNPYPHVMLSISPMEEERITDDIFQELWRVLMNPSLVGTDQWYLRDAEMYLLLMRCLIHRLDWEAAAHLTIKTMESLTYTYMMDHEVTLMFKEIGDPAGCLAFKVATKLFDGRILKDGQSKREKFHQEQFGEL
Protein: Elongation factor 3 (EF-3) (EC 3.6.4.-) (Eukaryotic elongation factor 3) (eEF3) (D0MYB4)
Organism: Phytophthora infestans (strain T30-4) (Potato late blight agent)
Function: Ribosome-dependent ATPase that functions in cytoplasmic translation elongation. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P16521}.
Interaction partners:
- 40S ribosomal protein S15
- 40S ribosomal protein S5-2
- 40S ribosomal protein S14
- 60S ribosomal protein L8, putative
- Small ribosomal subunit protein uS2
- 50S ribosomal protein L5
- 60S ribosomal protein L23a
- 40S ribosomal protein S3
- 60S ribosomal protein L9
- 60S ribosomal protein L7
Sequence:
MAPYAPTDGISKLAIDQSKHFTEALKEALKSSADQQKVAAEKVSELVAGDANLNLGVVSQELRNALTGNDADAKVVAAHVVDDLMQKHAERVEAYLLPLLSVFLDLLGDKKPTVRPVAQEAALTIISSANKNSTIRILPILFDGLDRSKKWQTKKGALDLIAELSKVAPYQVGRCLPDIIPQVTDCMWDTRKEVKVAARDTMTKVCNVVGNMDIEPFIPALVSCLANPTEVPECTHKLASTTFVKTVEAPALAIMEPLLKRALAEGKTAVKRQAAVIIDNMCKLMDDPAEAQLFIPKLLPGLKKVIETQADPECREVATRAHETLFVAGGSMEVSEDELKVDYANIHKVVVESIAANPTAVKANIDSFVVDYVTGICYFLVVSRNFNKAVFEKEITTYIKAFMKPEEIKPLANEIRDRCFKENKSIFIEDVDCDEGIPDLCNCEFSLAYGGMILLNNARLRLKRGHRYGLCGPNGCGKSTLMRAISNGQLEGFPSRDELKTVFVEHNLQASEAELSVVDFILVDEDLKNTPRKEVEDTLAGVGFTAEMQAQGVGTLSGGWKMKLELARAMLQKADILLLDEPTNHLDVKNVAWLENYLTSLTNVTSIMVSHDSGFLDTVCTNIIHYETRKLKIYKGNLSKFVEQKPEAKAYYELESENVKFIFPEPGFLADIKNKGKPIIRLTNCSYQYPGTPKPSINNISVTCALSSRIAVLGPNGAGKSTLIKMLTGEVEPTSGQVWKHPSMRFAYVAQHAFHHIESHLDETANQYIQWRFQSGEDKELLAKETRKLSKEEKEHYKKPVNWEGEKRVLEEIVSRRKFKKSFEYELKWEKCPVDDNAWVPREKCEKWGWDKLLQIADDREAARANLQARPPTAIAVQKHLDCFGLGAEFGTHSRMRGLSGGQKVKVVLAAAMWLNPHILVLDEPTNYLDRDSLGALASAIKEFNGGVVMITHHNEFSSALTQETWNVEAGFLVIEGQQAEDKTKIEQKNEEEVTDAFGNVTKTKIKRKLTRKEKKAKDKARKEAEARGEYYSDSDEE
Protein: Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) (P32322)
Organism: Homo sapiens (Human)
Function: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19648921, ECO:0000269|PubMed:23024808}.
Interaction partners:
- Pyrroline-5-carboxylate reductase 2
- Pyrroline-5-carboxylate reductase 3
- Delta-1-pyrroline-5-carboxylate synthase
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Proline dehydrogenase
- Proline dehydrogenase 1, mitochondrial
- Protein jagged-2
- Prolyl 4-hydroxylase subunit alpha-2
- Hydroxyproline dehydrogenase
- Pre-mRNA cleavage complex 2 protein Pcf11
Sequence:
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
Protein: Sodium/potassium-transporting ATPase subunit alpha (A0A060YJC3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta-2
- Potassium-transporting ATPase subunit beta
- Potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Uncharacterized protein
- Nucleoside-diphosphate kinase
Sequence:
MDELKKEVDLDDHKLTLDELNRKYGTDLSKGLSSAKAAENLARDGPNSLTPPPTTPEWVKFCKQMFGGFSMLLWTGALLCFLAYGIQAAMEDEPANDNLYLGVVLSAVVIVTGCFSYYQEAKSSKIMDSFKNLVPQQALVVRDGEKMNINAQQVVVGDLVEVKGGDRIPADLRIISASGCKVDNSSLTGESEPQTRTPDYSNDNPLETRNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGRTPISIEIEHFIHIITGVAVFLGMSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTSFDRSSATWAALARVAGLCNRAVFLAEQSGIPILKRDVAGDASESALLKCIELCCGSVQGMRDQYTKVAEIPFNSTNKYQLSVHLNKNEGESKHLLVMKGAPERILDRCSTILIQGKEQPLDDEMKDSFQNAYMELGGLGERVLGFCHFQLPDDQFAEGFQFDCEEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNEVDPRDAKACVVHGGDLKDLSAEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLFFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSKTDKLVNERLISIAYGQIGMIQALAGFFTYFVILAENGFLPSRLLGIRVDWDNKFCNDLEDSYGQQWTYEQRKIVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMRNKILIFGLFEETALAAFLSYCPGMGIALRMYPLKPSWWFCAFPYSLLIFIYDEIRKLIIRRSPGGWVERETYY
Protein: Putative rRNA methyltransferase (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog) (Q586Q7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03163}.
Interaction partners:
- rRNA processing protein, putative
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar complex protein 2
- Ribosome biogenesis protein NSA1
- Ribosome biogenesis protein NSA2 homolog
- Protein MAK16 homolog
- Pescadillo homolog
- Nucleolar protein, putative
- Nucleolar RNA binding protein, putative
- Ribosome biogenesis protein NOP53
Sequence:
MGTKSKKKAKTRLDAYYRLAKDQGFRARSAFKLVQLNRKYDFLSKCRVLVDLCAAPGSWCQVAAKHMPVGSKIVGVDLVPIAPIRGVKTFVGDITEEKTKKIIMTYLKREPVDCVIHDGAPNVGGVWSRDLFEQNSLVLHAAKLASKLLRPGGWFVTKVFRSQDFHKLMWVMKQLFDKVEATKPLASRMESAEIFVTCAGYKAPKQLDPAMFNPQKVFSDVEEEKILTPSGALVVPRSNVPAGYEEFATVQQHVASFSEFMSSSDPKAFLRSHHELRFTTPEEKAFLKSKHSKKELVYLCGDLQQVGDADLRRLVRWREQLLREQARELKQRAASDANAGDIAEEDEEEEKDDDKFDFDSAEGVAKIARELLELRKKQSKEMKKKQKKIVDRKLKQIKGLINYDPNTSAEHMTDADGFTHDADGVEGSDVGEEDSSEDGEDDEGFTVGKLAAVDEADVANILDKHWEEPDERLNDPLNPVMNANLNLEKDWDVGSDEKEGGDDEQYDGSGRLVRSIQLVEGEEDGVDVDNYGNYIPAKRSARVALYEEGLSKPGAEEDESEGEDEGEDDATRHKRERHQTTLDAAGKQSKWLRHHVNIEKVLRDTFPMPRSDSGNRRKKSKRLEEDRVEMSAPGPLRDDTAGSSTSTRKKMRFDARVDDDDDDMNSVSDLSDGRFSDDRSDLEVNVGRVDSRRKRAIVPDIGKLTTQELVRQQRKQTLKENAEKRRQRGNSGNSKDTEFEEVPVALTDPEVRARTLAIATKMLDPRGRREILDASINRYTFNDDEDLPDWFLKDEQRNCRVVLPVTAEEVEAQRARFREMNARPGKKVMEAVQRKRRRAQRMLRGLIERGKVDPRTREKANNLSVRKLMRSQAVKGNGGRRKNGPLDRKKMGELRRDKQRAKRRK
Protein: Alpha1-proteinase inhibitor-degradation deficient protein 37 (Q03233)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ER-associated protein degradation (ERAD).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MAIKPTKSFQNCLEAEVPGYNDCPTVLFSIDPNSGPRSKSKQRTKSKRCVSGRLATEVLDLYGNTKTATTPPPVLRRPSVTAAQQESACEGVLVKDQGDRQLQPILCSKEELVAKINDLCVCGSKLSSKELEFYKKKLDSNITKILQNEHTKTVLSQIFNEKDKNMAVKTIKHWMVTDTTISNWCPAFLKIFENAMPN
Protein: Protein DCL homolog, chloroplastic (AtDCL) (Q9C642)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for normal plastid function and plant development. Required for correct plastid ribosome assembly. Required for processing and maturation of 4.5S rRNA.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:15197595}.
Interaction partners:
- Endoribonuclease Dicer homolog 2
- Double-stranded RNA-binding protein 1
- Endoribonuclease Dicer homolog 3
- Endoribonuclease Dicer homolog 1
- Dicer-like protein 4
- RNA-dependent RNA polymerase 6
- RNA-dependent RNA polymerase 2
- Protein argonaute 1
- Protein argonaute 4
- Protein argonaute 2
Sequence:
MSLASIPSSSPVASPYFRCRTYIFSFSSSPLCLYFPRGDSTSLRPRVRALRTESDGAKIGNSESYGSELLRRPRIASEESSEEEEEEEEENSEGDEFVDWEDKILEVTVPLVGFVRMILHSGKYANRDRLSPEHERTIIEMLLPYHPECEKKIGCGIDYIMVGHHPDFESSRCMFIVRKDGEVVDFSYWKCIKGLIKKKYPLYADSFILRHFRKRRQNR
Protein: Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) (Q9D7J7)
Organism: Mus musculus (Mouse)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
Interaction partners:
- Calpain-2 catalytic subunit
- Calpain-7
- Calpain-5
- Calpain-6
- Calpain-1 catalytic subunit
- Calpain-8
- Calpain-10
- Calpain-13
- Calpain-15
- Calpastatin
Sequence:
MFLAKAILEGADRGLGGALGGLLGGGGQARAGGGNIGGILGGIVNFISEAAAAQYTPEPPPQQQHFTVVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKELKTEGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVFKQYDSDHSGSLGSSQLHGAMQAAGFQLNEQLYLMIVRRYADEDGGMDFNNFISCLVRLDAMFRAFKALDRDRDGLIQVSIREWLQLTMYS
Protein: GLIS family zinc finger 3 (A1L1Q6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAQISPLKVHTPASLYPESNSAQSLRRQVLTNGKLGFPQPSRALHQQAPQISLPASSSSKQSARQCCQDSGMKGYRRVFGSCGSSNLQVSSGAFLVQSLSPASATVTHSSTQTCPQNTLTLPFNEASRCLLSRESLASTTLSLAETQSVRSSKLDWPYGYRVLPPLGHQTANQLSESTVPESSLSESVSNPASLPHYLFKEDGSSPRLSARSKKRALSLSPLSDGLGLDLNSIIRTSPTSLVAYIIGSRISPASHNTPSPLQADVCGHLLGIRGSGIPTSSKHSISVSESLRMQPLEDQFTNLLVEQQILPDPQTAKASQTHTLQFEVSRIVRSPSPPRGPPPPYSAHHQQQQQPRVLQLQRPAGLQPMLEEEEEEEESCGGTHCCCWLHCGAIYSHRDALVKHIEKIHVDQRKGEDFTCFWAGCARKHKPFNARYKLLIHMRVHSGEKPNKCSFEGCQKAFSRLENLKIHLRSHTGEKPYVCPHPGCLKAFSNSSDRAKHQRTHVDTKPYACQIQGCGKRYTDPSSLRKHVKSHSLKEQQARKKLRRSSDLSQDGLSECLTVQPLQHSLSTLDLIESKHHSPTDDLYTVFTLNQPSQTNTLNSPMQIAGGPQTHQSPHQTHQAHQIHQTQTHLTHQTHQAHQTQTHHIQQIHQTHLTHQIQQIHQTHLSPHGPLPPLQGNNRFLSPNSHKAPGFCSQPRTSAQDGFSAVFSYADSDKHISSCSVMQTPMFEDNLSSSPQIHSNISVLDCQSGPQGFIGEQEPSVSEDNYLHIPRCPSRISCVFTEG
Protein: Nicotinamide nucleotide adenylyltransferase 3 (A0A2R8Y594)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKALFSTPAGILKRILQTLFEHLTGTDSGLRLRTETASPSPHLKLETGYEWSCA
Protein: Nucleic acid-binding, OB-fold-like protein (Q9LII1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 4C
- PIF1 helicase
- PIF1 helicase
- PIF1 helicase
- Replication protein A 14 kDa subunit B
- DNA polymerase epsilon subunit B
- Partner of SLD five 1
- Regulator of chromosome condensation
Sequence:
MANSMATLSRRLYRSLLSNPRISQASMSFCTNNITSPEDSDFDELESPIEPKASDPVSRFSGEERVMEERPLENGLDSGIFKAILVGQVGQLPLQKKLKSGRTVTLFSVGTGGIRNNRRPLINEDPREYASRSAVQWHRVSVYPERLADLVLKNVEPGTVIYLEGNLETKIFTDPVTGLVRRIREVAIRRNGRVVFLGKAGDMQQPSSAELRGVGYY
Protein: Protein indeterminate-domain 4, chloroplastic (Q8GYC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that may act a transcriptional activator of nuclear-encoded photosynthetic gene expression (Probable). Binds DNA via its zinc fingers. Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA.
Subcellular location: [Isoform 1]: Plastid, chloroplast {ECO:0000305|PubMed:16934950}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:24821766}.
Interaction partners:
- AT-rich interactive domain-containing protein 4
- Cytochrome P450 71B2
Sequence:
MSSSSYNTSVIPSSSSSAQPFFITSSGTGDNDFNRKDTFMSMIQQPNSSAPPPKKRRNQPGNPNPDAEVVALSPKTLMATNRFICDVCNKGFQREQNLQLHRRGHNLPWKLKQKSTKEVKRKVYLCPEPTCVHHDPSRALGDLTGIKKHYYRKHGEKKWKCEKCSKRYAVQSDWKAHSKTCGTKEYRCDCGTIFSRRDSYITHRAFCDALIQETARNPTVSFTSMTAASSGVGSGGIYGRLGGGSALSHHHLSDHPNFGFNPLVGYNLNIASSDNRRDFIPQSSNPNFLIQSASSQGMLNTTPNNNNQSFMNQHGLIQFDPVDNINLKSSGTNNSFFNLGFFQENTKNSETSLPSLYSTDVLVHHREENLNAGSNVSATALLQKATQMGSVTSNDPSALFRGLASSSNSSSVIANHFGGGRIMENDNNGNLQGLMNSLAAVNGGGGSGGSIFDVQFGDNGNMSGSDKLTLDFLGVGGMVRNVNRGGGGGGRGSARGGVSLDGEAKFPEQNYPFGRG
Protein: TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6) (B5DF45)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN (By similarity). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y4K3}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9Y4K3}. Nucleus {ECO:0000250|UniProtKB:Q9Y4K3}. Lipid droplet {ECO:0000250|UniProtKB:P70196}. Note=RSAD2/viperin recruits it to the lipid droplet. {ECO:0000250|UniProtKB:P70196}.
Interaction partners:
- Toll-like receptor 4
- Sequestosome-1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Interleukin-1 receptor-associated kinase-like 2
- Mitochondrial antiviral-signaling protein
- TIR domain-containing adapter molecule 2
- Interferon regulatory factor 7.
- Interleukin-1 receptor-associated kinase 4
- Interleukin-1 receptor-associated kinase 1
- Mitogen-activated protein kinase kinase kinase 7
Sequence:
MSLLNCENSCASSQSSSDCCAAMANSCSAAMKDDSVSGCVSTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMHVSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV
Protein: KAZ1-type serine protease inhibitor-like protein type delta (Q8IRJ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAQCYPQFDSENPWLRPRQPTEPTISPNAGGSTPANAAPPTTQSPRYFACFHSCPATSEYNPICGSDNVNYYNENKFNCALNCGLNIRKVHKGICQT
Protein: Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1) (Q5XG87)
Organism: Homo sapiens (Human)
Function: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm. {ECO:0000269|PubMed:23376078}.
Interaction partners:
- Zinc finger CCHC domain-containing protein 7
- Exosome RNA helicase MTR4
- DNA polymerase lambda
- DNA-directed DNA/RNA polymerase mu
- Exosome complex component 10
- Poly
- Poly
- Unconventional prefoldin RPB5 interactor 1
- Poly
- Zinc finger CCHC domain-containing protein 8
Sequence:
MDPRVAWIQPEQKGPANALWMQIWETSQGVGRGGSGFASYFCLNSPALDTAAAAGAAGRGSGGLGPALPAASPPPPGPTAPAALPPALLTALGPAAEGARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGGGRGGAFFNFADGAPSAPGTANGHPGPRGPAPAGSPSQHQFHPGRRKRENKASTYGLNYLLSGSRAAALSGGGGPGAQAPRPGTPWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSASSVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQTRFTIPPPTLGVAPVPCRQAGVEGTASLKAVHHMSSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHGHTQGGGYSSVGSGGVRPPVGNRGHHQYNRTGWRRKKHTHTRDSLPVSLSR
Protein: Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)] (Q9NZW4)
Organism: Homo sapiens (Human)
Function: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Dentin matrix acidic phosphoprotein 1
- Matrix extracellular phosphoglycoprotein
- Integrin beta-6
- Integrin-binding sialoprotein
- Integrin beta-1
- Integrin alpha-V
- Enamelin
- Osteopontin
- Ameloblastin
- Osteocalcin
Sequence:
MKIITYFCIWAVAWAIPVPQSKPLERHVEKSMNLHLLARSNVSVQDELNASGTIKESGVLVHEGDRGRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAETYGHDGIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD