wanglab/gogpt-training-data huggingface dataset:
Protein: Calmodulin-binding transcription activator 1 (AtCAMTA1) (Ethylene-induced calmodulin-binding protein b) (EICBP.b) (Signal-responsive protein 2) (AtSR2) (Q9FY74)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds calmodulin in a calcium-dependent manner in vitro. Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance. Involved in freezing tolerance in association with CAMTA2 and CAMTA3. Contributes together with CAMTA2 and CAMTA3 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2. Involved in drought stress responses by regulating several drought-responsive genes. Involved in auxin signaling and responses to abiotic stresses. Activates the expression of the V-PPase proton pump AVP1 in pollen.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00767, ECO:0000269|PubMed:11925432}.
Interaction partners:
- Dehydration-responsive element-binding protein 1C
- Zinc finger CCCH domain-containing protein 16
- Calmodulin-binding protein 60 G
- Zinc finger protein ZAT12
- Dehydration-responsive element-binding protein 1B
- U-box domain-containing protein 7
- Calmodulin-7
- IQ domain-containing protein IQM6
- Serine--tRNA ligase, chloroplastic/mitochondrial
- Calmodulin-1
Sequence:
MVDRRSFGSITPPLQLDMEQLLSEAQHRWLRPTEICEILQNYHKFHIASESPTRPASGSLFLFDRKVLRYFRKDGHNWRKKKDGKTIREAHEKLKVGSIDVLHCYYAHGEANENFQRRCYWMLEQHLMHIVFVHYLEVKGNRTSIGMKENNSNSVNGTASVNIDSTASPTSTLSSLCEDADTGDSQQASSVLRPSPEPQTGNRYGWTPAPGMRNVSQVHGNRVRESDSQRLVDVRALDTVGNSLTRFHDQPYCNNLLTQMQPSNTDSMLVEENSEKGGRLKAEHIRNPLQTQFNWQDDTDLALFEQSAQDNFETFSSLLGSENLQPFGISYQAPPSNMDSEYMPVMKILRRSEDSLKKVDSFSKWAIKELGEMEDLQMQSSRGDIAWTTVECETAAAGISLSPSLSEDQRFTIVDFWPKSAKTDAEVEVMVIGTFLLSPQEVTKYNWSCMFGEVEVPAEILVDGVLCCHAPPHTAGHVPFYVTCSNRFACSEVREFDFLSGSTQKINATDVYGTYTNEASLQLRFEKMLAHRDFVHEHHIFEDVGDKRRQISKIMLLKEEKEYLLPGTYQRDSTKQEPKGQLFRELFEEELYIWLIHKVTEEGKGPNILDEDGQGILHFVAALGYDWAIKPVLAAGVNINFRDANGWSALHWAAFSGREETVAVLVSLGADAGALTDPSPELPLGKTAADLAYANGHRGISGFLAESSLTSYLEKLTVDSKENSPANSCGEKAVQTVSERTAAPMTYGDVPEKLSLKDSLTAVRNATQAADRLHQVFRMQSFQRKQLCDIGDDEKIDISDQLAVSFAASKTKNPGQGDVSLSCAATHIQKKYRGWKKRKEFLLIRQRIVKIQAHVRGHQVRKQYRTVIWSVGLLEKIILRWRRKGNGLRGFKRNAVAKTVEPEPPVSAICPRIPQEDEYDYLKEGRKQTEERLQKALTRVKSMVQYPEARDQYRRLLTVVEGFRENEASSSASINNKEEEAVNCEEDDFIDIESLLNDDTLMMSISP
Protein: Transcription factor (O77025)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00810}.
Interaction partners:
Sequence:
MMKRTRVDEVQFGTRPVPQTSGGVGVGVVGVTGGGPTSGGGGTATVGVNTTGVTIGTVVPSAHNATISGIGSIHHRILTPQHGGAQTIAYLPSTTPTATNLKTTSSIVDSTTAGGPVGAGAQVAVGVGSAAGGGGVVVSTGSTGTQTLQYTTSYSVASIQAGGTLKANTADGANTVQIHVTGGGAANNPASAQTVSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLASPFLMKFPDLLRWLTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEANEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEEQVRQLFEHRRNRIEQHGTAASLESISVDSAISSNSTTGGGGSGSNNNNNNNNNNSWGGKRLERLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYRIYNRYRVVQSAVSGGLMSATAPTPDGSVPAVNSAPSGSVSTVNNVQGSAAVSSTSHSMCNSSILSADSTTNTNASAQQQQHCNSAAAATTPNAEALQQVRPMES
Protein: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) (Q99640)
Organism: Homo sapiens (Human)
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}.
Interaction partners:
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- G2/mitotic-specific cyclin-B1
- G2/mitotic-specific cyclin-B2
- Cyclin-A2
- Metalloreductase STEAP3
- Proto-oncogene serine/threonine-protein kinase mos
- M-phase inducer phosphatase 1
- Cyclin-dependent kinases regulatory subunit 2
- Ribosomal protein S6 kinase alpha-1
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
Protein: Alkaline phosphatase (EC 3.1.3.1) (A0A0G2JZL2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
Interaction partners:
Sequence:
MQGAWVLLLLGFRLQLSLSVIPVEEENPAFWNQKAADALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGNLGPETPLAMDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGNEVLSVMYRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGCKDIATQLVSNMDINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLSKHQGSQYVWNRQELIQKSLDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVGTGERPNVTDAESHDPSYQQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSTTTTTTTTTTTTTRVQNSASSLGPATGPLALALLAKALMLLLGAPADF
Protein: Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (TCDD-inducible poly [ADP-ribose] polymerase) (Q8C1B2)
Organism: Mus musculus (Mouse)
Function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:23275542}.
Interaction partners:
Sequence:
MEVETTEPEPDCVVQPPSPSDDFSCQMRISEKISPLKTCFKKKQEQKRLGTGTLRSLRPILNTLLESGSLDGVFRARDQNRDESSLHEHIVKKPLEINPSCPPAENSMPVLIPDGTNVEGQLPEAHPSTDAPEQGVPIQDHSFPPETISGTVADSTTGHFQTDLLHPVSGDVPTSPDCVDKVMDYVPGAFQDNSFTIQYILDTSDKLSTELFQDKSEEASLELVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVSNDSQEHLERFYCNPENDRMRMKYGGQDFWADLNAMTVFETTEFDQLRRLSTPPCSNSNSIYHTFWKFFCRDHFGWREYPESVVRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILIPYLQTLGGVPTQASLPLEATSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMSGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
Protein: Syndecan (Q8I4H9)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
Interaction partners:
Sequence:
MILKLNFCLSTYSVLILLSLSTQAFAANQAKTKVVPSSTISTKSLKNGISEVEGSANIPGRLADIEVNGSGYPTDDEDGDDVHGSGKPPSSATTKSDKVTSPSHAVVTAKPTTVPTTTASFKPPVQPKPKPAANDKEIKVEEDEDDDEDEDEDDEDDEEDFADENIHNDEDFFTTTTTTTYRPIVVATTSTPRSAATNPPRQQPPMVTSTISSGPFSPFHETLANGFYAAIAGGVLVAVITAILLVLFVVFRIRKKDEGSYALDEPKQARPYASYGYTKASTKEFYA
Protein: Single-stranded-DNA-specific exonuclease RecJ (D0EM60)
Organism: Deinococcus radiodurans
Interaction partners:
Sequence:
MSRPAHWLLAPPASRDALLATMREWQVSPPVAQVLCGRDLRTELLALPLELTPNPALREAARHIVAAVREGKRIRIHGDYDADGVSATATLVLGLRAIGANVHGFIPHRLNEGYGIHPDRVPEHAAAADLVVTVDCGVSNLDEVKSLLATGTEVVVTDHHAPGENFPECLVVHPHLTPDYDPDRHNLTGAGVAYHLLWAVYEELGRPEPRALLPLATLGTVADVAPLLGENRALVRAGLAEMARTELPGLRALMNEKRVRQPTARDVAFILAPRINAAGRMGEADRALELLTTPSDHEAKSLAAYLEIRNQERRKIQDDMFAQALQLADPNDPALVLTHDDWHAGVMGIVASKLVETFNRPVYIVAQGKGSVRSTPGISAVQGLRESRDLLGRFGGHPGAAGFSLDPQNFGALRERIHGYVRQFPTPVPAVRLDAPLPVAALTPELLSELSILEPFGEGNPRPLWHLRGPLTDTRLVGKQGDVLQFRFGGVKGMKYSERDDAAGERDVAAELALNEWKGRTSLELHAAALRPLAPLALAGTEEGLPTLPRLNPREAMTFLKTGAAAYAEQGVATYLRDNVPGLTLLDTNAPHPGGDLILYGLPPESALRRWLHEAQEQGGRVAFALGPKTLAELDAALTLAKLLPDSHTEAAQEAAADAYRSWQWAHHYRVLNDAGWSASVYAMLGLPVPAALPKAAEALALAAG
Protein: Exodeoxyribonuclease I (ExoI) (Exonuclease I) (EC 3.1.11.1) (DNA deoxyribophosphodiesterase) (dRPase) (P04995)
Organism: Escherichia coli (strain K12)
Function: Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.
Interaction partners:
- Single-stranded-DNA-specific exonuclease RecJ
- Single-stranded DNA-binding protein
- RecBCD enzyme subunit RecB
- RecBCD enzyme subunit RecC
- DNA replication and repair protein RecF
- ATP-dependent DNA helicase RecQ
- Exodeoxyribonuclease 10
- UPF0759 protein YecE
- Nuclease SbcCD subunit C
- Protein RecA
Sequence:
MMNDGKQQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPENDDGLPSFRLEHLTKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLKALWQYAEEIV
Protein: Ras GTPase-activating-like protein IQGAP1 (Q9JKF1)
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P46940}. Nucleus {ECO:0000269|PubMed:20883816}. Cytoplasm {ECO:0000269|PubMed:20883816}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20951348}. Apical cell membrane {ECO:0000269|PubMed:35601831}. Basolateral cell membrane {ECO:0000269|PubMed:35601831}. Note=Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).
Interaction partners:
- Catenin beta-1
- Cell division control protein 42 homolog
- CAP-Gly domain-containing linker protein 1
- Ras-related C3 botulinum toxin substrate 1
- Cadherin-1
- Calmodulin-1
- Dual specificity mitogen-activated protein kinase kinase 1
- Mitogen-activated protein kinase 3
- Calmodulin-like protein 4
- Actin, cytoplasmic 1
Sequence:
MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRVAADTFTALKNPNAMLVNLEEGLAPTYQDVLYQAKQDKMTNAKNRTENSDRERDVYEELLTQAEIQGNVNKVNTSSALANISLALEQGCAVTLLKALQSLALGLRGLQTQNSDWYMKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANSAAQQYQRRLAAVAAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPELTVAVEMLSSVALINRALESGDMTTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNAFITWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFALGISAINEAVDSGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNNSKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQLWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQVACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESCGNSNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPDKMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRRYRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Protein: Rap-GAP domain-containing protein (H9G2Q2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHHSHYPQSSSNASTSSSPPSQPQQPFSVQLNEVVARFTSKLLFLREPSIVTPSGFTEDHNHNVISGLSLHSVDLDDIPDAMSPMMGRSDSNAVLSGGHNAVGRRKSVGSSCSSVAGESDVMSSTSTAGGHSQKHPEDYQQVDGVTAGRAAALASLIRIITSKSSNEKIPNSQLSNFYATVFQCLVEKERVMLCTLFYYGRNLFRLGLPGIESLLPHFLFALDIVMIESSKLRLHPSISEVEVRRACLRALSSVICWPTTFGMSKIPQIAEAANLKSNAATYLHLRSRIFKTLMFSVRNETDPTNLHIALSLCAVLVEESCQFDLGLNEEQTKEMIRISTTASSSGQPEKGLCASIVRGVLSAICDKFGRIETIDHSTALAIIDVLNCISHVHHTVLFNNMDVSTGTLVIASLCRFIEQQLNKPPPMHSKDLHSTVVAAYNAVAVWLTASPLLAECVGVLGTVCDVIQLGVTGSKTSPDLQKSRGETVKPKAASQRVLEAAEALMYTLFCVVGRKPGPLRDEKRLVHKYGPNRINTSKFLHVLVNGDTLLSLHEASHIDDIPSDSASVVYVRRSPMQGANTGIARLRPKPENYHPEVGIPPMTPMSAASTTEGFEVNSTSTTLCDSSSKLSVSSTTSAPASQNSVTEKLSIASKVTTRTAPAALIAVPSSSIVTTGSILTGVVINSTSTPTFYEESDEDRMGYESDGPNTPKVQKSIGEQFVIPPEFYKNSCKLDNAFRNLESTTETEAIAEEMKQQNSQNGRSFFDESRRNNVFERMRPEERIVAPSKPLDTCSSIRMMLYDFGLINERIFGSEIVLLDSSMSEKFYRDLHETVDCAPARTQLTAHIFYVKEGQRIAVDILENALNVQNSCSDFCMFLANLGEGIEIGVHDTWTGHWSTAYSTERKLQEEADGVDHYIVDGIQHALWWCDEQGSNSELAFLMPTERSVRMFKQNITSPASSSRRGSNNNRSIVSDDKSFDSTHTDNGMMLNARRLGEKSPSNLSDRDFRPYAGGGSSMGHGSVGRRTGALKIMLVWLERPEDMTSFPIYELIGTCDDGTDLLNGGAQKPEIGGATNSQVAHHIIFIHLVEPGIVQIRTRGTVNRFGEAGPLVDGVVVSLANLPSFIRNTILNTSRRDVAEIENYTFPHTRRKQAIVEFAKKYAAKTSYEEFLVNVIQN
Protein: Nucleoside triphosphate/diphosphate phosphatase (EC 3.6.1.15) (EC 3.6.1.6) (Q97NV6)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYIDYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFSEAYVNIWYKRYVELKNR
Protein: Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-5) (Q91V87)
Organism: Mus musculus (Mouse)
Function: Has a negative effect on cell proliferation.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Fibroblast growth factor 2
- Fibroblast growth factor 8
- Fibroblast growth factor 10
- Fibroblast growth factor 22
- Fibroblast growth factor 18
- Fibroblast growth factor 3
- Fibroblast growth factor 4
- Fibroblast growth factor 5
- Fibroblast growth factor 17
- Fibroblast growth factor 1
Sequence:
MTRSPALLLLLLGALPSAEAARGPPRMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKESPGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNKAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPMASSSSSTSLPWPVVIGIPAGAVFILGTVLLWLCQTKKKPCAPASTLPVPGHRPPGTSRERSGDKDLPSLAVGICEEHGSAMAPQHILASGSTAGPKLYPKLYTDVHTHTHTHTCTHTLSCGGQGSSTPACPLSVLNTANLQALCPEVGIWGPRQQVGRIENNGGRVS
Protein: Probable serine transporter (P42628)
Organism: Escherichia coli (strain K12)
Function: Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein.
Interaction partners:
- UPF0597 protein YhaM
- Probable HTH-type transcriptional regulator YhaJ
- DNA-binding transcriptional activator DecR
Sequence:
MEIASNKGVIADASTPAGRAGMSESEWREAIKFDSTDTGWVIMSIGMAIGAGIVFLPVQVGLMGLWVFLLSSVIGYPAMYLFQRLFINTLAESPECKDYPSVISGYLGKNWGILLGALYFVMLVIWMFVYSTAITNDSASYLHTFGVTEGLLSDSPFYGLVLICILVAISSRGEKLLFKISTGMVLTKLLVVAALGVSMVGMWHLYNVGSLPPLGLLVKNAIITLPFTLTSILFIQTLSPMVISYRSREKSIEVARHKALRAMNIAFGILFVTVFFYAVSFTLAMGHDEAVKAYEQNISALAIAAQFISGDGAAWVKVVSVILNIFAVMTAFFGVYLGFREATQGIVMNILRRKMPAEKINENLVQRGIMIFAILLAWSAIVLNAPVLSFTSICSPIFGMVGCLIPAWLVYKVPALHKYKGMSLYLIIVTGLLLCVSPFLAFS
Protein: At1g61690 (Phosphoinositide binding protein) (Q6NPS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein ELC-like
- Protein ELC
- Ubiquitin-conjugating enzyme/RWD-like protein
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- Ubiquitin-ribosomal protein eS31x fusion protein
- F12P19.9 protein family with FYVE zinc finger domain-containing protein)
- Regulator of chromosome condensation
- Regulator of chromosome condensation
- Ubiquitin carboxyl-terminal hydrolase 27
Sequence:
MLEKIGLPPKPSLRGNSWVVDASHCQGCSSQFTFINRKHHCRRCGGLFCGTCTQQRLSLRGQGDSPVRICEPCKKIEEAARFELRHGYKNRAAKGGSSKRTVKNEDDVLSEILGSDVDVSSSSESVSSTDRNASKEMASSSSNKGMELDASPEELRKQAVEAKNKYRILKGEGKSDEALKAFKRGRELEREADALEISLRRNRKRELSMRNVAETQNKAATKESSKSQKPLRQGGKGNDDLAADLRELGWSDDEDKKPATISLEGEFSSLLREIPRSANPQKTGGIDKSQVIALKRKALTLKREGKLAEAKDELKKAKILERELEEQELLGGADGSDDELSALINSMDDDKEDDLLAQYEGSHDFDISNLVGNLDDIGVHGEYDVTDEDMEDPAIAAALKSLGWSEDPGHHENVHSRPSPKNRDESLAEIQTLKREALNLKRAGNVVEAMATLKKAKLLEKELEAADTSSETVDTTRAERDTSLKPPPRSRLAIQKELLAVKKKALTLRREGKFNEAEEELKKGAVLQNQLDELDNSSKLAATGKATREKGNDLPDISSLDDDGEVDVKDEELNDPNYLSMLKSLGWNDEDNNPAGPSSEKSDPLNSRPGKTAEAQGAYEVRVTKPRRTKAEIQRELLGLKRKALTLRRQGNVDEAEEVLNQTQILEAQIMEIDSGKNLYADSDQPKKRSNDLATDSRLNGGDDSVTENDMKDPALLSTLKNLGWEDEEPKKEEASFGSVQSSGPRIAAKSKGQIQRELLDLKRKALAFKRQGKTGDADELYSKASVLEAQLAELETPKMEMKGSASAIKPENYMDVDLLVGSQMEDKAIKSASVSHAPQDSYDLLGDFISPAKSGSSGVVSQPGQQQPSMMDLLTGEHSERSQIHAEKGNAETMSGFRSGNNHGAEQRVAREESEPSHIQSASIQNTSPQNTLKQEILAHKKKALALKREGNISEAKKALQEAKLLERRLQEGENPSPEKLGRDDMVSTTEDPPAREKENSPSSSAPKAMSGRDRFKLQQESLSHKRQAMKLRREGKMQEAEAEFEIAKTLEAQLEDSTSSKPEPVDDVAVEDFLDPQLLSALKAIGLDNPVNPPPVSKTDTTQAAAKPNPVKESNRNTNNQERSQLEERIKAEKVKAVTFKRAGKQAEALDALRRAKLYEKKLNALASS
Protein: Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta) (P49770)
Organism: Homo sapiens (Human)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9UT76}.
Interaction partners:
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit 3
- Translation initiation factor eIF2B subunit alpha
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 2
- Guanine nucleotide exchange factor MSS4
- Opsin-3
- Thymidine phosphorylase
Sequence:
MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL
Protein: Rhodanese domain-containing protein (Q581R0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MAMRDVIGDPDLLLRKTPANPKYEHVKPVVETGMTAELARFMKNTGAALYRVSGEPFMRIRTRLIGDFVQKQQSQSGEIKDGGFAHPMDEYRAPDTQLPKEYLILDVRSEEEYAACHIKGALHYPKRRMVHAINPLLPEMFNFKNKENKLIVLYDLEEEMTIAQGIGQNVFEKGIDNLAVMTGGLREFVQDYADCIVGESPVPIVPRDTRLLKRAEAVSAARSETQRSAFSHKPKSLSNSLAKPRPR
Protein: RecQ mediated genome instability protein 1 OB-fold domain-containing protein (Q581X8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA 3'-5' helicase
- DNA topoisomerase
- DNA 3'-5' helicase
- BRCT domain-containing protein
- DNA topoisomerase
- DNA topoisomerase
- Crossover junction endonuclease MUS81
- DNA repair protein RAD51 homolog
- DNA repair protein, putative
- Uncharacterized protein
Sequence:
MAALHEEVRTRYHIAVCTRFVERVCVDTPSPTAEFIYKMALNENLKDITDVCTLPRVSLLQLNSLPCSLVLQVSSSRDVTQPLRPCLDASEEEPILTAAFQKNLKTRLLRLVLSDGHSEVPAVELSTLSVFRSIPVPGEKLLVKEGAEIKNGAIIMTDDCVVPLGGGVQQLKKEVLIQQSRSDAPRFQPLRFGVSTPAGARAAAGPLSDSFDRDRGGNVGRARGRGLGYRGGRGSGYRGQRPHNHHYNRPQ
Protein: Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) (Q64018)
Organism: Mus musculus (Mouse)
Function: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (By similarity). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:12975813, ECO:0000305|PubMed:17114051, ECO:0000305|PubMed:24801766}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:12975813, ECO:0000269|PubMed:17114051, ECO:0000269|PubMed:24801766}. Perikaryon {ECO:0000269|PubMed:24801766}. Cell projection, dendrite {ECO:0000269|PubMed:24801766}. Cell membrane {ECO:0000269|PubMed:16672662, ECO:0000305|PubMed:9145798}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415, ECO:0000305}.
Interaction partners:
- Gephyrin
- Glycine--tRNA ligase
- Sodium- and chloride-dependent glycine transporter 2
- Glycine receptor subunit beta
- Glutamate receptor ionotropic, NMDA 3A
Sequence:
MYSFNTLRFYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK