wanglab/gogpt-training-data huggingface dataset:
Protein: Plasma membrane ATPase 2 (EC 7.1.2.1) (Proton pump 2) (P19657)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Plasma membrane ATPase 1
- Inorganic pyrophosphatase, mitochondrial
- Inorganic pyrophosphatase
- Protein BTN1
Sequence:
MSSTEAKQYKEKPSKEYLHASDGDDPANNSAASSSSSSSTSTSASSSAAAVPRKAAAASAADDSDSDEDIDQLIDELQSNYGEGDESGEEEVRTDGVHAGQRVVPEKDLSTDPAYGLTSDEVARRRKKYGLNQMAEENESLIVKFLMFFVGPIQFVMEAAAILAAGLSDWVDVGVICALLLLNASVGFIQEFQAGSIVDELKKTLANTATVIRDGQLIEIPANEVVPGEILQLESGTIAPADGRIVTEDCFLQIDQSAITGESLAAEKHYGDEVFSSSTVKTGEAFMVVTATGDNTFVGRAAALVGQASGVEGHFTEVLNGIGIILLVLVIATLLLVWTACFYRTVGIVSILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLIEYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESPEGERIVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEILGVMPCMDPPRDDTAQTINEARNLGLRIKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIAILNNSLDINLIVFIAIFADVATLTIAYDNAPYAPEPVKWNLPRLWGMSIILGIVLAIGSWITLTTMFLPNGGIIQNFGAMNGVMFLQISLTENWLIFVTRAAGPFWSSIPSWQLAGAVFAVDIIATMFTLFGWWSENWTDIVSVVRVWIWSIGIFCVLGGFYYIMSTSQAFDRLMNGKSLKEKKSTRSVEDFMAAMQRVSTQHEKSS
Protein: Hemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C) (Q7TQ32)
Organism: Mus musculus (Mouse)
Function: Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Also released in the extracellular space. {ECO:0000250|UniProtKB:Q6ZVN8}.
Interaction partners:
- Neogenin
- Transferrin receptor protein 2
- Hereditary hemochromatosis protein homolog
- Bone morphogenetic protein 6
- Transferrin receptor protein 1
- Transmembrane protease serine 6
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein 2
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1B
Sequence:
MGQSPSPRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSSTLSLRGGGSPDTPRGGGRGGLASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTAPPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRAPGFLHCASFGDPHVRSFHNQFHTCRVQGAWPLLDNDFLFVQATSSPVSSGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSINGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIIRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQTALDDARIFLTDLENLHLFPSDAGPPLSPAICLVPLLSALFVLWLCFSK
Protein: 2-nitroimidazole transporter (P76242)
Organism: Escherichia coli (strain K12)
Function: Involved in efflux of 2-nitroimidazole.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- HTH-type transcriptional regulator NimR
Sequence:
MTCSTSLSGKNRIVLIAGILMIATTLRVTFTGAAPLLDTIRSAYSLTTAQTGLLTTLPLLAFALISPLAAPVARRFGMERSLFAALLLICAGIAIRSLPSPYLLFGGTAVIGGGIALGNVLLPGLIKRDFPHSVARLTGAYSLTMGAAAALGSAMVVPLALNGFGWQGALLMLMCFPLLALFLWLPQWRSQQHANLSTSRALHTRGIWRSPLAWQVTLFLGINSLVYYVIIGWLPAILISHGYSEAQAGSLHGLLQLATAAPGLLIPLFLHHVKDQRGIAAFVALMCAVGAVGLCFMPAHAITWTLLFGFGSGATMILGLTFIGLRASSAHQAAALSGMAQSVGYLLAACGPPLMGKIHDANGNWSVPLMGVAILSLLMAIFGLCAGRDKEIR
Protein: Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) (Q13761)
Organism: Homo sapiens (Human)
Function: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Cytoplasm {ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000269|PubMed:20599712}.
Interaction partners:
- Core-binding factor subunit beta
- T-box transcription factor TBX21
- Runt-related transcription factor 1
- Catenin beta-1
- Zinc finger homeobox protein 3
- Mothers against decapentaplegic homolog 3
- Histone acetyltransferase p300
- Cellular tumor antigen p53
- Runt-related transcription factor 2
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MRIPVDPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLPTLTESRFPDPRMHYPGAMSAAFPYSATPSGTSISSLSVAGMPATSRFHHTYLPPPYPGAPQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSSSGGDRSPTRMLASCTSSAASVAAGNLMNPSLGGQSDGVEADGSHSNSPTALSTPGRMDEAVWRPY
Protein: Low-affinity Zn(2+) transporter (A0A1D8PGN5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362088}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362088}.
Interaction partners:
- Zn
- Csr1p
- pH-regulated antigen PRA1
Sequence:
MNSDSISQVFEYLNKRDECPTDNDYNGNIGTRISSIFVIMVTSAIGTLLPLLSSKYSFIRLPPMVYFICKYFGSGVIVATAFIHLLEPAADSLGNKCLTGPITEYPWAFGICLMTLFLLFFFELLAYQGIDRKIAKESQLDNQGPHTHSHFGDASMYVKKDDEEEDLENQNEKQADANPYPSHFAHAQEHQDPDVMGTTVNDQSKEQYYGQLLGVFVLEFGVMFHSVFIGLALAVSGDEFKSLYIVLVFHQMFEGLGLGTRIATTNWARHRYTPWILAICYTLCTPIAIAVGLGVRKSYPPGSRRALITNGVFDSISAGILLYTGIVELMAHEFLYSGEFKGPGGFKNMLLAYFVMCWGAGLMALLGKWA
Protein: Eukaryotic translation initiation factor 2-alpha kinase 1 (PfeIK1) (eIF2alpha kinase 1) (EC 2.7.11.1) (Q8IL26)
Organism: Plasmodium falciparum (isolate 3D7)
Function: In blood stage parasites, phosphorylates translation factor eIF2alpha in response to amino acid starvation. During the asexual blood stage, involved in the response to the host hormone melatonin which is used by the parasite to modulate its cell cycle.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
Sequence:
MTSEDKTALCAENILNDIYILTINRNIDIDIIQEGLLRKVMDEEESNSILFLEDSSFSKNDISILNVHLKIEDGKNKYNNYYEFKYADINVTIDFYQKECKYSIEKSNMHKCHYFKMMNKINYITEQKMDFKDSILYLYNTINDKNFFKCPCWLNDNKNIKLNNIINDHQQKKKKKNLYDKSVQVTNDVTNIMVNEIQEQKMKKPIFFDNKNDLNNSDDEFNSAHSSLIKINKLLNVEENDIFHNLKGHVYEEYFDKHEDNKNQKDNIESNIIVKDKKDRANNIISEQMKEDYIKNVEEVLSKHINNNKNNNVEDSVSLYSLDEEISEQIDKQHFFSIDKRQDEISNFIQMEENINDHMNDNINKMGKKKHGKENRVVEDEKYIQDDKKKKRFYRNVNDNIPLTVQLANKGNEICKEIIEMNSRYYRDFFEEKILGCGGFGYVMKVKNKKFNITYALKIIRLSNSKYNTQTNNKHINEKDNNSYIMEEAIMIAKLQHENIVRYYDAWVEENVDFFLYKELQNEFKNIKIKIKNEKMKNEKMKNEKIISGKIKNENIKSENIKSENIKSENIKSENIKSEKVKNLYIEEIKYFWNHYKKNKDPNVNDKYLYILMEYCPGKTLREAIDCGFICRNEKLIWELIKQILKGISYIHDMKIMHRDIKPSNIFLQITDNILIAKIGDFGLTTRIGDTQINPSAGTIHYISPEQLNGEPFNEKADIFSLGVVFFEMFHEPFSTSMERSITLSNLLKGIYPEYMKADNKKFQFLSSLLAINPQERCCAYNLLHESVLFTFEKDFTDIYNLIDNKRNCEEVHTIISTLFDKFEYLNSDKILKKEDFSTFQNAKIFTDDLEMRKKQKIIKKKILISLKKRGAIFILTPIILLNKYYINLENTYMEEYNIYYNINKKKENKINNIYINTNKNKNIDNLIYMLDIYGNSITLRNSFFLSFAEYIYESIDSYNKYNEDNLFYKFYTYGYTYKNQIIKSNKHIKKDTINNNINTTINITTTTCNTTTGTSTNNNNNNNNNNMGNNNIGNNMGNNVSNIISNNNINNHMISNNPFYFYNIYPDENEKMFYCILSSSKNVFGNEELNYLSIFSNADIMVSIYTLYNHINYFNKLLFVWSYIDLLEIILKECLDIPNDISYHLSIDLKKNSTLLVNKSFVMSLLQKYKIKDMSKISDHILSLFYIKCESNKVDDYLNNIYNFVDDLLNKKSSLQLKRNTSITPKEVPYVRSRSNNISTSASKIIKYDIQKNVGTKEKGNQNDNEKKKMQIYSILDRIKKINNFICTNTVINNTCFDLFLNYEESIFCNEVIFYVICESKNKEIIAYGGRFDEIIRNMANEVKYKNHANYKYVYNNIKDIYNNNNNNNNNDNNIMNIKAYGVEIYLDKIYSKVIESNEKISIHLQYNPSTDKSQLFKNFVTSCQQNDFACTSHIIQQPLLNDDYLNYSSTKILIQVYEISNLLIAYDLSKKLLTKNISSYTHLSINNVNIKKKIKNFKPHKIQFFITIKSNNTDNSFDALKPINFDNVVYKIVNYDDQDCNFMDQAELINYLIKYF
Protein: Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) (P18847)
Organism: Homo sapiens (Human)
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12034827}.
Interaction partners:
- Transcription factor Jun
- Protein c-Fos
- Transcription factor JunD
- Cyclic AMP-dependent transcription factor ATF-4
- Mothers against decapentaplegic homolog 3
- DNA damage-inducible transcript 3 protein
- Cellular tumor antigen p53
- CCAAT/enhancer-binding protein beta
- Transcription factor JunB
- E3 ubiquitin-protein ligase Mdm2
Sequence:
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS
Protein: Allantoinase (EC 3.5.2.5) (P32375)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. Involved in the utilization of purines as secondary nitrogen sources, when primary sources are limiting.
Interaction partners:
- Allantoicase
- Ureidoglycolate lyase
- Urea amidolyase
- Allantoin permease
- Protein DAL82
- Nitrogen regulatory protein DAL80
- Dihydroorotate dehydrogenase
- Transcriptional activator protein DAL81
- Protein DCG1
- Protein transport protein GOT1
Sequence:
MPINAITSDHVIINGANKPATIVYSTESGTILDVLEGSVVMEKTEITKYEIHTLENVSPCTILPGLVDSHVHLNEPGRTSWEGFETGTQAAISGGVTTVVDMPLNAIPPTTNVENFRIKLEAAEGQMWCDVGFWGGLVPHNLPDLIPLVKAGVRGFKGFLLDSGVEEFPPIGKEYIEEALKVLAEEDTMMMFHAELPKAHEDQQQPEQSHREYSSFLSSRPDSFEIDAINLILECLRARNGPVPPVHIVHLASMKAIPLIRKARASGLPVTTETCFHYLCIAAEQIPDGATYFKCCPPIRSESNRQGLWDALREGVIGSVVSDHSPCTPELKNLQKGDFFDSWGGIASVGLGLPLMFTQGCSLVDIVTWCCKNTSHQVGLSHQKGTIAPGYDADLVVFDTASKHKISNSSVYFKNKLTAYNGMTVKGTVLKTILRGQVVYTNANGVSKTPLGQTLLDSRR
Protein: ATP synthase peripheral stalk subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d) (Q9DCX2)
Organism: Mus musculus (Mouse)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
Sequence:
MAGRKLALKTIDWVSFVEVMPQNQKAIGNALKSWNETFHARLASLSEKPPAIDWAYYRANVAKPGLVDDFEKKYNALKIPVPEDKYTALVDQEEKEDVKSCAEFVSGSQLRIQEYEKQLEKMRNIIPFDQMTIDDLNEIFPETKLDKKKYPYWPHQPIENL
Protein: Probable WRKY transcription factor 21 (WRKY DNA-binding protein 21) (O04336)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- MLO-like protein 3
- Protein PHLOEM UNLOADING MODULATOR
- VQ motif-containing protein 20
Sequence:
MEEIEGTNRAAVESCHRVLNLLHRSQQQDHVGFEKNLVSETREAVIRFKRVGSLLSSSVGHARFRRAKKLQSHVSQSLLLDPCQQRTTEVPSSSSQKTPVLRSGFQELSLRQPSDSLTLGTRSFSLNSNAKAPLLQLNQQTMPPSNYPTLFPVQQQQQQQQQQQQQEQQQQQQQQQQQFHERLQAHHLHQQQQLQKHQAELMLRKCNGGISLSFDNSSCTPTMSSTRSFVSSLSIDGSVANIEGKNSFHFGVPSSTDQNSLHSKRKCPLKGDEHGSLKCGSSSRCHCAKKRKHRVRRSIRVPAISNKVADIPPDDYSWRKYGQKPIKGSPYPRGYYKCSSMRGCPARKHVERCLEDPAMLIVTYEAEHNHPKLPSQAITT
Protein: Receptor protein-tyrosine kinase (EC 2.7.10.1) (Q5G254)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGQQVLALCALLFLCVPQPVTSQTQEVCTGTKNALSSTGTPEQHYNNLKERYTGCEIVMGNLEITQMENDLDFSFLGSIREVTGYILIAMNQFRKLPLNQLRVIRGSSLYDKEWALSVFHNFDTHTGLEDLGLTNLTEILEGGVQIVHNRNLSYAPLINWQDIVRDGDARIQIQDNGGRGSCNPACGEFCWGPSNDQCQKLTKTVCALQCLGHCFGTNPNECCHPECAGGCTGPRDTDCFACRHVNYSGSCVPHCPWPVVYNQQTFQVEPNADAMYQFGSICVPKCPGHFVVDGSACVSSCPPGKTEIEKNQIKQCETCIGLCPKVCEGTGANHRQTVDSSNIDSFINCTKIQGSLHFLILGIKGDVYNNIPPLEPEKLKVFNTVREITGILNIQSWPDELHDLSVFSSLTTIQGRSLYNPNTPFSMLMMKIPSLTSLGLRSMREISDGSVYITQNMNLCYHHTINWTQIFPRNQLQRRRNDIKENKQKIQCEEEGHVCDPLCSDAGCWGPGPEQCLSCRNYSRLGTCVSHCNLYSGEPREFAASNKECLACHSECLLQNGKQTCLGKGADQCVACSNLMDGPHCVSSCPNGVNGEKGQTIFKYSTAAGHCELCHFNCTRGCTGPALRDCVDPDRNVNSSQIAGIAVAVFAGITVLLALFVLGMLYHRGLAIRRKRALRRYLESGESMEPLDPGEKGTKVHARILKPQELRKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTIQNRSSRQTFTEITDHMLSMGSLDHPYIVRLIGICPGASLQLITQLSPHGSLLQHLRQHKDSLDPQRLLNWCVQIAKGMYYLEEHCMAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVYSEHKTSIKWMALESILFGRYTHQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVKCWMIDENVRPTFKELASEFTRMARDPPRYLVVRPAQNGGGAEESQRYVKSSHLEVGLEEEDDDEDEGLQVGFATPPLQLSPTRSHSRVRIASYKSTSEHTAPIGYLPMTPGPGDEPRQLRAQRRKTGSVRTESECSEGRGTIVDIEAVEITSQTGSLRRGRSRMDSAYISGGVSVASDPFSSGLEGVDEDHYGYVLPTERDFRSAVPHGRTSRNSKSTPKTDATQEYELMNKQTNKLSSSPTDSTDHLKPASLVSAHICSSLPQKKEMDSAQTQDEILPQKRETDSTQSQENNLPQKSETDSTQTQESEKDASFQPDNFESAENCLIGSETLNDGGQSEEEEQQPRLAMVEYEYMDIRTDEHQQNVAGKRTTNGPNEVEREAIYQNISQPLRFHENPDSAGNTMQRRGEYVDMEASGRSGCEVGDYQNVPVKGRPVVGEESQNTGLRSYIKVCAGVEPQNTSFDNPDYWHSRLFHKQDTVCT
Protein: Daxx-like protein (Q8WSS9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRRSPAKRRRLEDPLRLLTPSGRQSFPAKLLNIPKASLGSAMVVPVAETGPARETPVIVDPLRSMHIPSGITITKHQKNVLATNGNMNLSLAESNNNNNTTSLNKNVTPKQINVGTGQKVAWSVSSKAPSPNAVITTVPSHQVRVTPFNPIRLAPGSKIIPASNAMPAKIQPILGMGQPQQQAQAQQPKAIIVGFPKPNTAVAQMAQHQKPLTLQIHQKLIAGQQQHIASISQLQQVSLQQQQPLRPVSIQLQQQQNQRNGSLPGKQQKPLECPVPAQQEKLPRGPLPTKPAEPLSGPLPTEPDEPLGGPLPTRPKPPVRSLQQPVNKNTAIGVQIQQSQEPLGGTLPTRQKPLGGQLLTQQKPPVGSIQQSVKQNTGIGVQIQQIPKVVVGQQPQKVYLNKLQQEQQKIFLGHLQQQQQKTFLGQLQQEQQKILGQLQQQKQQQQQQQKKILGQSQQQKVPLGQPQPQQKLPQQLNNSLVQLQQQHQQRTSVGQLQQQQPHQSQQKNSMVHVKQQPQQQKKISVGQFQQQPQQQQKTSVAQLQQQPQQQQKISVGQLQQQSQQQQKPSVGQLQQQSQQQQTPLVGQLQRQTQQQQKTSAGQFQQQPQQQQKISAGQLQEHSQQQQKTLAGQLQQQAQQQLNTSAGQLQQQQKPPKASLAQQAAAQKQGAGLGQQQQFQSQPQQRTSAGLLQQQQMPQKKIVMQPQLPKTSVVLPRPQQLPKNPLLVAQQQSPKTPLVNSVMGPQFPSQQPSLPVVNQITHKSMTIQRLPMLQTVQKILPKQIAPQQTPPPAHIVQKQTMPNAAMQNPPFAHRPPIVRPMTVAKISPVPTNNKVCIPMKPQMASYVSPTDPTMTAARTLPFRSSQRKTSEAPMTSTHVQGFTASATPPQRLLATPPHCAAALNEPLLLNLPPTTSITPQLTPTTTPPPAGPSAAVQQQQLAKAAAIKLNSLPEASISPVNRSPTASAKRIQPITVLKKSDEEWQRHLEQQQQKKHVQLQSSSMTTIVLVESPPTTPPTDKPEPERGPMTVEKSSIKPMATDKQSRAIKRPAVMISTKKSGLVVTEIVDLDEIPDIPPEKRGKECFPPIKNAAKAAPSVNAPFTTEYAALLRLCREVDKSTHMERLVKGELTQYYYSAPESFVMSCGFRNLVTMAMARIRSESYLVYVHLKYVLDELASRRLTKMFPTVRAIPPASQFPLPPASQFPLPPTLTTPKQPAIVKAPGQQTVMAGREQDDEVEEVTLVNVGTVSCEERRRDERIRHFYRTLHAITKRIKMLEEAEVDLNDEDSSYLQLERFKKRACQIYEKICDLKGESKSVRRQLKKPIHFKDSDYPHFNNSLSAFVNRMQDFPDYHDVLQILEKCNKEKELGLAKYEMKRIAYDAFNKVGRMLQSRRKNDLYETVTHYTANGKDPASSDPELLAKLKENNKKQTKISDILEKYALEQDLNAEERQEARLKEKKLKQVKADEEAAKLAALAEDDDKPCTSAQAAAKAAALAALKRGPAARGNVIRKKRAANGRIFKIADDGDDSEEESDSEDDDVEEFVNNFQANSDVSDADSEVEAVTSPKRDALPLAEEEDVIDITRDETGKKNDEGTPNGRLKIMSVSSLNANFVHGQDLHRKPNPMPSAKPVIADQIIISDEES
Protein: Transcription termination factor MTERF4, chloroplastic (Mitochondrial transcription termination factor 4) (Protein BELAYA SMERT') (Protein RUGOSA2) (Q9ZT96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription termination factor required for processing and steady-state levels of plastid transcripts. Required for splicing of the chloroplastic Clp protease (ClpP) group IIa intron. Required for maturation of 16S rRNA and 23S rRNA in the chloroplast. Essential for embryogenesis. Required for the maintenance of the correct levels of transcripts in the mitochondria and chloroplasts.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21464319, ECO:0000269|PubMed:21790815}. Mitochondrion {ECO:0000269|PubMed:21790815}.
Interaction partners:
- Transcription termination factor MTEF18, mitochondrial
- Protein WHAT'S THIS FACTOR 1 homolog
- CRM-domain containing factor CFM2, chloroplastic
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- CRS2-associated factor 2, chloroplastic
- Mitochondrial transcription termination factor family protein
- Holliday junction resolvase MOC1, chloroplastic
- Protein THYLAKOID ASSEMBLY 8, chloroplastic
- Large ribosomal subunit protein uL2mz, N-terminal part
- Ribosomal protein L2.
Sequence:
MKIRFCNGFTKPGFLLVHFEPPSFFAVRSRSLSDSTYGNLCNHKKRPGTGIGLTVQCAIANRRFSSRSLDSPRRERSSRSSSSSGRDRDRDKDKGRDSKSLYSRPSLLDMNKEKAANRAKVYEFLRGIGIVPDELDGLELPVTADVMKERVEFLHKLGLTIEDINNYPLVLGCSVKKNMVPVLDYLGKLGVRKSTFTEFLRRYPQVLHSSVVIDLAPVVKYLQGLDIKPSDVPRVLERYPEVLGFKLEGTMSTSVAYLVGIGVARREIGGILTRYPEILGMRVARIIKPLVEYLEVLGIPRLAAARLIEKRPHILGFELDDTVKPNVQILQDFNVRETSLPSIIAQYPEIIGIDLKPKLDTQRKLLCSAIHLNPEDLGSLIERMPQFVSLSESPMLKHIDFLTKCGFSIDQTREMVIGCPQVLALNLGIMKLSFEYFQKEMKRPLQDLVDFPAFFTYGLESTVKPRHKKIIKKGIKCSLAWMLNCSDEKFEQRMSYDTIDIEEVETDPSSFDMNTLMQPEREEESDSEYEEEEDDDDEEFA
Protein: Protein lin-10 (Abnormal cell lineage protein 10) (O17583)
Organism: Caenorhabditis elegans
Function: Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glr-1 subunit of AMPA-type glutamate receptors (AMPRs) in the ventral nerve cord. This may be partly through interacting with the small GTPase rab-6.2 in its active GTP-bound state.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10359617}; Peripheral membrane protein {ECO:0000269|PubMed:10359617}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10359617}; Peripheral membrane protein {ECO:0000269|PubMed:10359617}. Cytoplasm {ECO:0000269|PubMed:22252129}. Synapse {ECO:0000269|PubMed:17671168}. Perikaryon {ECO:0000269|PubMed:22213799}. Note=In trans cisternae of Golgi or trans-Golgi network (PubMed:10359617). Localizes to Golgi-associated structures (PubMed:22213799). Partially co-localizes with glr-1 at the synapse (PubMed:17671168). Localizes in endosome-like structures in ventral cord dendrites. During hypoxia, diffused cytoplasmic localization. Localization in the ventral nerve cord is regulated by egl-9 isoform e and cdk-5 (PubMed:22252129). Co-localizes with rab-6.2 in neuronal cell bodies (PubMed:22213799). Co-localizes with rme-8 in puntate structures in neuronal cell bodies and in the intestine (PubMed:22213799). {ECO:0000269|PubMed:10359617, ECO:0000269|PubMed:17671168, ECO:0000269|PubMed:22213799, ECO:0000269|PubMed:22252129}.
Interaction partners:
- Protein lin-2
- Protein lin-7 homolog
- Amyloid-beta-like protein
- Glutamate receptor 1
- Acetylcholine regulator unc-18
- Syntaxin-1A homolog
- Guanylate kinase
- Syntaxin-binding protein 1
- Ras-related protein rab-6.2
- Synaptobrevin-1
Sequence:
MSSEAVAQATAATTSPEHGVPTSSATPTPPPSKGGGAGGGGGGEQQQVPFQMIPPGHFFANPFLNPYIPTAGAPAQEGEAQPQMVFSPAQYQEVMHHYFQQMMAASGAQFPIPFPMQFQPALQQPRPSSQASSSHRSEDDNGRQTAGSVVSSNVSPNHREVRPAEDSTETSGVVQNNDELLVPTSTSSDVTIGDVIEKSDSPENSQESAGGEEKSEEKRKLSGDRTDSLIRKQMSEMEKEITRRSQNKNIKTIDDDGLAELIGGSSTRTVADDFSPFVDKSGLSYTAPAPPSTEKSAPKESLNQLRSSFNLPDDSTTVGPVGPSTVPQQSQQFANNSMFMANAGNFVQNAFPIGVTMTPQATFGAAPGFQMMQPHQHNLFMQQPNPTFVNNGTNPFLQTQATLPNFVQNGTAPLVPTVSAQQFTPEQLAAAFAQQQIAQSAAPTPFDSPPPSMPSTSSGPSGALAPPPPPSHPIPRRVSGNGWPEENKENGTSTSTTNGAQSVPAAAGTDDPVWVLRDSYLKKMQREQRTSEEEEMSWQEAATAAQEAAENGGGDDQEEQETDRLLNGGTTGASTKGAERRGSVDKKKNSKETMVHEPAVLIEGVLFRARYLGSTQMLCESRGSKAARMAQAQEAVARVKAPEGDVQPSTEIDLFISTEKIMVLNTDLQRISDTDVRQDILMDHALRTISYIADIGDLVVLMARRMSTSHSDESCSDGDSSGGGVRKTPKVICHVFESDEASFIAQSIGQAFQVAYVEFLRANGIDDPSYLRQIDYQEVLNSQELLGDELEMFAKKETQKEVVVPKKAGEPLGIVVVESGWGSMLPTVVLAHMNPVGPAAHSNKLNIGDQIININGISLVGLPLSAAQTQIKNMKTATAVRMTVVSTPPVVEVRIRRPDTKYQLGFSVQNGVICSLLRGGIAERGGIRVGHRIIEINGTSVVAVAHDRIVNMLATAVGEIHMKTMPTSMFRLLTGQEQPQYI