Protein: Chondramide synthase cmdD [Includes: ATP-dependent phenylalanine adenylase (PheA) (Phenylalanine activase); ATP-dependent tyrosine adenylase (TrpA) (Tyrosine activase)] (Q0VZ70)
Organism: Chondromyces crocatus
Function: Involved in the synthesis of chondramides. Activates R-beta-tyrosine and probably phenylalanine.
Interaction partners:
- Antibiotic synthesis protein MbtH
- Polyketide synthase
- Polyketide synthase
- Peptide synthetase
- Hybrid polyketide synthase/nonribosomal polypetide synthetase
- Polyketide synthase
- Uncharacterized protein
- Polyketide synthase
- Polyketide synthase
- TugA
Sequence:
MLREGQGTVAHAPPRPLPHADVLPVSQAQRRLWFLCQLDGASVAYNMPFVTALDGHLDARALQRALDEIIRRHESLRTTFRLQAEGPVQVIHPPAPLDLPLHDLRSLDEPARAAEIQRRIDRAAHQPFDIERGPLLRAQLLRQSETRHVLCLVIHHIVADGWSIGVFVREFEALYGAFSASRPSPLTEPPLQYADFSRWQEERFPPSAVERHLTYWKQKLSDVQPLQLPADHPRPAVESFRGDHTIFRLDRGLTRGLHELAQCEGVTLFITLLSAFNVLLGRYSGQDDLAIASGTANRKHAELEGLIGFFVNTVVIRTDLSGNPTFRTVLSRVLASVMEATEHEDLPFERVVEELKPERTASHNPLAQVALTLQSFASNRLTLPGLTTSPCDFRFRTSKLDLMLLVTEVDGELEVVVEYNTDLFEDATIARMSAHLRTVMAAMVADPGARIGDISLLTTEERHRLLVDWNDTALACPEAEGVHHAFEQNAARQPDAIAVVFDGDPISRITYGALNERANQLAHHLIQQGVGPDVVVGIHVERSITMIVALLAVLKAGGAYLPLDPTYPQQRLAFILADAGAQVILTQEKWFDDLPPHTARVLDLDAIAPQLDANATSNPPLRATADHLAYIIYTSGSTGNPKGVLIPRRDTWSVARALAETYALTPESRVLQFASLNFDGSVVEITMTLFSGAALHVAPQEKLLPGAPLNAFLQRHAITHVQLAPSLLARLPPEGLEHVRTIMVAGEASSVGTVRGWLPGRRILNGYGPTETTVGAAMIAFTEADDAYLAKLDALPIGRPFYNKRVYLLDARLQPVPVGVPGEIYVASPGLARGYINRPAATAEKFLPNPFSETPGERIYRTGDLARYLPDGNLVFLGRVDNQVKLRGLRIELEEIESALKSHPHVGDAAVIVHEAPADQATSERDGKRLVAYVVPRRGWEPEGAQSDHIASWQTLHEQLLDESQAPEDWSFNITGWKSSYTGEALPAAEMRLWVESTVERILAHGPKDVLEIGTGTGLLLARIAPRVRAYLATDFSLEAIRYLETCKARAPELSNVTLLQRMADDFTGFSAGQFDTIVLNSVVQYFPTLDYLSAVIEGALRVLKPGGTLFLGDIRNLALLDAFHASVQTAKASGTLSRDELRYRVQQGVMNENELVIDPRFFTALSRKFPQITHVEVTPKRGLHRNELTLFRYDVALQVGGTPKGAPTITWFDWREEGLTSDSLPPWLSDTLATSPDAGVGLRRVPNARLQPDLAILSWLATRAEASLDAWRARQHDVPEGCAPEALWALETTWPGRVHLSWAAGHPDGSFDLVVTPPQAERRAPWSPAVDLTDEQLSAYVNHPLQAKVVRETLGQELRRYLQDKLPAYMVPTVLIPLPALPLTSNGKLDRRALPAPDIERRSRASTYVAPRNAREETLVAIWSKVLGVDPIGVEDNFFELGGDSILSIQIVGQAKQAGFSLTSRQMFEHQTIAALAEVASASKSIQAEQGLVEGSIPLTPIQRWFFETHQETPDHFNQAILLKVSADVSASRLEQAFHHLFTHHDALRMRFSRTADGFEQVNLGPIEGVTVDVIDLAHLPAAEQTRALTEAATSLQQRLSITSGPLSRIALIHLGAEQPARLLWILHHLVVDGVSWRILLDDLVTVLRQLEAGQPARFPPKTTSFKEWSERLHATAQQEQANTASSRAERDAWRSVPVPALPLDHPQGTNRKASAAQVQVALSVADTHALLHDAPRAYGTQVNDLLLTALALAFNAWTGDATLALDLEGHGREEDLVGADLSRTVGWFTTMHPVALRLPGRELSLALRAVKEQLRAQPGRGIAYGLFRYASGEGSLASWPAPQVNFNYLGQLDAMTDTAPLLGFAPEEIGPSDGPTGDRTHLFQVNGMVKDGSLQFTWTYSRELHRPETVQKLAHDFAETARRLTQHCLAHESHPTPGDFPAVTLSQNQLDVVLDALGADRDNVAAIYPLTSLQEGLLFHSLSAVPAPVPALADEDDEEDDELDEEFDAEVDEEDEDEEEEEDDDGENVYVTQLVFRIQGPLDAEKFRTAWQETVQRHPLLRSRFVWEGCERPLQVVLRSADLRWEEDELEEDSWSSPLRVHARREQQAGMLLDEAPLFRLNLLRAEDTEHHLIWTSHHILLDGWSGPLILKDVFASYDAQLLGESRTAADPPPYEAYVAWLKRQDGTASERFWRENLRGFSAPTPLVVDNEEPTGKQKHLHHRCKLSAETSQALKALAESFRVTLSTVYQAAWALLLHRYSGMSDVLFGVTVSGREADVPGIEEMVGLFIRTVPLRLHVDESQTLGAWLKEVQARQIEQREHQYVSLVDIQRWSDVPGGTQLFDSMFVFENYPLDSALLEQSGLRLTVSTMASPTHYPLVIAVVPGRTVETLFDHDTSRLSKHTVERLAAHWVELLTGMARRPDARIHTLPHLTSAEREKLLVTWNARPYVDEQRKYRGEEEPFGEELAAESTFLDLFQHHVAQTPDALALVGPSLQSTDERPVSRTYRALSARVHLLARHLRGLGVGPEVTVGVCLDRSIELVIGMLAIFEAGGVYLPLDPSQPLERLAYLVSDARPEVVLTQQRWNDRLPEQATRRVALDTAWAEIEAQPEVSHQHRTAGDNLAYVLYTSGSTGTPKGVQVTVDNLSRLTPALITAFDVTPRSRVLQYSSLSFDGSISEVAMALGAGAALHLAPAHELVPGPPLQKLLATRAITHVTLLPAALRWLSPRGLPALDVLIVTGEACPASLVRTWASGRRFVNAYGPTEITVAATAMECPVTMFQETEQPPPIGCPLQSTEIYILDAHLRPVPVGVPGDLYIGGAKLTRGYIHRPALTAERYIPHPFSDRPGARLYVTGDIARYQLDGTIDFLGRRDNQVKVRGYRIELGEVEAALNDHPGVREAVVVAQKDGAGDNRLVAYWAAKSTPPTTTEALRDALSKRLAAYMIPSVFVRMDALPLNATGKIDRQGLPPVDDTMLDREQFVAPRTATEETLTAIWSSTLGVARVGIRDDFFKLGGHSLLALNITTQIQKRFGHVITVDSIFRAPTIAVLARVIDEALAPTGARRALSLVVPLRERGTKVPLFFAAGMGMHAHYLRPLAEHLGEDQPFYALQSPAQGGEITDMATLVDTLIGAIQQIQPSGPYHLGGHSAGARIAFAVALELQRRGAEVPLVSIVDMRPPGRGATSDESAEWTQIGGLIGYVTMIKQAIGEGVLFVTPEELRKLDEAAAWQRTLDAFIAARWMPKDADVEQLQHLCAMNQNVVRVVRDHVPTDTHQGKLLVFSAAFAMRNGRQVSTEGWQAFCANPVTTHEVPGDHMTMLREPDVRGLAIKLRREIDELALERTDEAPGLPTPPEFPVVWEHPEDARMLWVHDVTHCREQMTPLDFCLRQQAMVEGSNLANLAYGVPFTGEIRLINTYVYQKIIPTTASPTELAAAMKRAEASVAALLPDLGRWWTETLLPEIEAHLEALDPENNYDFVHRHTLVEALAEAHRRTARLWEIHFRLLQPVMLAISRFVDLCKDLSTDDDPIDPYALLVGFPNKTTEGNRALWSLSRLALETPEVASILTSNEASRVSWKLRSTRGGRAFVAQLDAYLATYGQRNDSTYLDAPTWEEDPTPVIRNLQAYMTQPERDLDAELNALSEQRTQRLDALRARLRHYPRAVVDEFEQALTAAQTATVLSEDHNYWIDYKITHRLRHLCLYLGEQLKDWELLGDCEEIFYLSMDDVSRAAVETKRGGPFSANQRFYHLACARKDEAKRFHGVQPPRFLGTPSPLPALHDALSLASARFTGVAPSPSNDEKEIVGLSGAKGKARGKARVARNLADVPTLEPGEILVAMAMLPAWTPLFATVAAIVTDSGGMLSHAAVVAREYGIPAVVGTQVGTQRIRDGQLVEVDGERGVVTLL