wanglab/gogpt-training-data huggingface dataset:
Protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) (O97902)
Organism: Bos taurus (Bovine)
Function: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Golgi apparatus {ECO:0000250|UniProtKB:Q9ULH1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9ULH1}. Note=Predominantly cytoplasmic. Partially membrane-associated. {ECO:0000250}.
Interaction partners:
- ADP ribosylation factor 6
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- Adenomatous polyposis coli protein
- Tyrosine-protein kinase
- ADP-ribosylation factor 4
- Rhodopsin
- Src substrate cortactin
- CD2 associated protein
- Adapter molecule crk
Sequence:
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGESSLEELTKAIIEDVQRLPGNDVCCDCGSAEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSSSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTALHYCSMYSKPECLKLLLRSKPTVDVVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEMDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLSLPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPIAEAPPLPPRNATKGPPGPPSTLPLSTQTSSGSSTLSKKRSPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDVGPSSSSKTTNKFEGLSQQSSTGSAKTALGPRVLPKLPQKVALRKTETSHHLSLDKANVPPEIFQKSSQLTELPQKPPPGDLPPKPTELAPKPPIGDLPPKPGELPPKPQLGDLPPKPQLADLPPKPQVKDLPPKPQLGELLAKPQTGDASPKAQPPLELTPKSHPADLSPNVPKQASEDTNDLTPTLPETPVPLPRKINTGKSKVRRVKTIYDCQADNDDELTFMEGEVIVVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Protein: C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] (Q8WZJ7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Serine hydroxymethyltransferase, mitochondrial
- Phosphoribosylglycinamide formyltransferase
- Methylenetetrahydrofolate dehydrogenase [NAD
- Methylenetetrahydrofolate reductase 2
- Bifunctional purine biosynthesis protein ade10
- Probable serine hydroxymethyltransferase, cytosolic
- Probable 5-formyltetrahydrofolate cyclo-ligase
- Methylenetetrahydrofolate reductase 1
- Dihydrofolate reductase
- Probable thymidylate synthase
Sequence:
MALLLEGTSLARKVREELREQISSIKSVDPYFNVSLKIIQVGGREDSNVYVRMKTRAANEAGISCEHVNFPEDITEYDLLLAIKGFNEDPTVHGIIVQLPLPAHINEQIITEAVAPEKDVDGFCETNLGKLTKREGQPLFTACTPKGIMCILKHYGINVQGKHAVVIGRSNIVGRPMSILLEKANATVTLCHSKTESIADIVRTADIVVAAIGIPHFVKADWLKKGVVAIDVGINSIPDATKKSGYRLTGDIDFENAKEVASAITPVPGSVGPMTVAMLLQNVVESAVRFRKMSRKRKPTLLPLKLQTPVPSDIEIARSQTPKNIGDLASEIGIAKSELEFYGSHKAKVNLEILQRLAHRRDGHYVVVTGITPTPFGEGKSTLTAGLVQALSNLDKLAIACVRQPSQGPTFGIKGGAAGGGYSQFIPMEEFNLHLTGDIHAITAATNLLAAAIDTRMFHENTQSDAALYKRLTLVKGNKREFAPVMFRRLKKLGIDKTNPEELTEEEQRKFARLDIEPSTISWNRTLDVNDRFLRKITIGENPTEKGFTRQTGFDLSVASECMSVLALATDLKDMRERLGRMVVASNKSGEPVTADDLGVGGALTVLLKDAIKPTLMQTLEGTPALVHAGPFANISIGASSILADRIALKLAGTEVDEDAKKEAGYVVTEAGFASDIGMEKFFNIKCRTSGLKPDAIVIVATVQALKLHGGGPPVGPGKPIPEVYKREDVDLVRKGCANLAKHISNARKYGLPVVVAINKFSSDSPNEISAIREEALAAGATDAVDSNHWAEGGKGALGVARALINACENVDSEFRLLYDVHEPIEKKIEIIAKEMYGADGIELSPLAKERLETFTKQGYNNLPICIAKTQYSLSHDPDLKGAPTNFTVPIRDMRLSAGAGFIYPLAAAISTIPGLPTKPAYYNIDIAENGDIVGLS
Protein: Signiferin-3.1 (P86128)
Organism: Crinia riparia (Streambank froglet) (Flinders Ranges froglet)
Function: Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 55.2 uM.
Subcellular location: Secreted {ECO:0000269|PubMed:16470724}.
Interaction partners:
Sequence:
GIAEFLNYIKSKA
Protein: KLF transcription factor 11 (E9PTS6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
Sequence:
MHSPGSTGPGDARAADIMDICESILERKRHDSERSTCSILEQTDIEAVEALVCMSSWGQRSQVRPLTPVSDSGDVTTAVLMDTAAPDLPKDFHSFSTLCITPPQSPELMEPTGTPVPSQVINSQGCMATALPPSPTGGPRTLSKGEPPEPSSESSCRAVMTSVIRHTGESPAPTCFPTGPTQEQPASDSRGGQDPLLDHLEALQDTRLADGLLVTNLVSCQPCLHKSGGLFPIDKGQQTVWPTAVQTCLPKNPESDLSRKTTPFISVPVSSPPVLCQMIPVAGQNGMLSAFLRPPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGNTKLLPLAPAPVFVASSQNCAPQVDFSRRRNYVCNFPGCRKTYFKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRITLAESPRSILEPLPASG
Protein: Kinesin-like protein KIN-14T (F4I1T9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Kinesin-like protein KIN-10A
Sequence:
MERTRSKPVRNLPETIHSLLGLKSHMTSDWVKSVCNIAKNTSSTSKKEEDDFVSVDLQSIRDQLSALTVQVNDQNKLRRQILNEFLDLKGNIRVFCRVKPLGATEKLRPPVASDTRNVIIKLSETKRKTYNFDRVFQPDSSQDDVFLEIEPVIKSVIDGYNACIFAYGQTGTGKTYTMEGLPNSPGIVPRAIKGLFKQVEESNHMFTIHFSMLEIYMGNLKDLLLSEATKPISPIPPSLSIHTDPNGEIDIENLVKLKVDDFNEILRLYKVGCRSRATASTNSNSVSSRSHCMIRVSVTSLGAPERRRETNKIWLVDLGGSERVLKTRATGRRFDEGKAINLSLSALGDVINSLQRKNSHIPYRNSKLTQVLKDSLGQDSKTLMLVHISPKEDDLCETICSLNFATRAKNIHLGQDESTEEQAKKEAVMMNLQKMMEKIEQEREMSLRKMRNLNETLEKLTGKPHVIEEEEKDVVREVIHVTPKKPRNKSRRASDVFPSFMRPTASSNRRLSGADFSVTPNSSSFKSRRNSMISVRAESACLPVKKKKNRFDSACDSSDRSVSKSTSIMRQNTADDATVYSQDISECDIKLVVSEHKPKPLQMGPGSATKSRSNISNFEKDVMQKIGGTEFSRINSWLRSQSENRSYVLDKTQLPATHFLENLNRSLEKSPTQSFTTEKITGNELEGIEETKTNETVVNPTLMLKKLFELQCLCSAEEEDQILSRFPIPGYEDDDESRYPPILENDGFSQHIDNEWFGVNNYSADWERDSPATIPLLECEPDLKQLLPELGLDRSLKPRGLAVAEGAAPPLLRAQETLGERGKGPTFMQKLQALCFRILLGLGFMDVGFGNDFFNGLTK
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (A2RI96)
Organism: Lactococcus lactis subsp. cremoris (strain MG1363)
Interaction partners:
- Putative hydrolase
- Foldase protein PrsA
Sequence:
MNTNKKNNTILFTIFGIVLIVVVGLLVFFANRPKTDDSSASSTNTSSSSQKVNYPTNYTLNAAVKNSSTALNDLTLPQLSTTVGEDEAEVQIKTSAGNINIKLFPKLAPNAVQNFLVLAKHGYYKNNEFFRVIKDFMIQSGDPSNKGTGTASIFGGKTFDTEISNQLYNIRGALALANTGQASSSSSQFFIVQNPQDMTSQIQDKSKYPQKIIDAYKKGGYPSLDGSHTVFGQFISGMDVVDKIAKADVKTNSSGESSAPIDPVKIKSVKILKDWKF
Protein: Lincosamide nucleotidyltransferase (Q9WVY4)
Organism: Enterococcus faecium (Streptococcus faecium)
Interaction partners:
Sequence:
MLKQKELIANVKNLTESDERITACMMYGSFTKGEGDQYSDIEFYIFLKHSITSNFDSSNWLFDVAPYLMLYKNEYGTEVVIFDNLIRGEFHFLSEKDMNIIPSFKDSGYIPDTKAMLIYDETGQLENYLSEISGARPNRLTEENANFLLCNFSNLWLMGINVLKRGEYARSLELLSQLQKNTLQLIRMAEKNADNWLNMSKNLEKEISLENYKKFAKTTARLDKVELFEAYKNSLLLVMDLQSHLIEQYNLKVTHDILERLLNYISE
Protein: Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) (Q6N043)
Organism: Homo sapiens (Human)
Function: May function as a transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Chromobox protein homolog 1
- Chromobox protein homolog 3
Sequence:
MGDNPFQPKSNSKMAELFMECEEEELEPWQKKVKEVEDDDDDEPIFVGEISSSKPAISNILNRVNPSSYSRGLKNGALSRGITAAFKPTSQHYTNPTSNPVPASPINFHPESRSSDSSVIVQPFSKPGYITNSSRVVSNKSSELLFDLTQDTGLSHYQGGPTLSMAGMSESSFLSKRPSTSEVNNVNPKKPKPSESVSGANSSAVLPSVKSPSVTSSQAMLAKGTNTSSNQSKNGTPFPRACPKCNIHFNLLDPLKNHMKYCCPDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIMLVNDFYYGKHEGDVQEEQKTHTTFKCFSCLKILKNNIRFMNHMKHHLELEKQSSESWENHTTCQHCYRQFPTPFQLQCHIESTHTPHEFSTICKICELSFETEHVLLQHMKDNHKPGEMPYVCQVCNYRSSSFSDVETHFRTSHENTKNLLCPFCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKMDHKTQHHRTFIKPKQLEGLPPGTKVTIRASVGPLQSGASPTPSISASASTLQLSPPRTKNITAKNPAKSNTSKPNTVKSNASKPNTSKPNGSKSKYKPKISNMQKKQSTLASSNKKSKVNTALRNLRYRRGIHKCIECCSEIKDFANHFPTYVHCSFCRYNTSCSKAYVNHMMSFHSNRPSKRFCIFKKHSENLRGITLVCLNCDFLSDVSGLDNMATHLSQHKTHTCQVVMQKVSVCIPTSEHLSELKKEAPAKEQEPVSKEIARPNMAERETETSNSESKQDKAASSKEKNGCNANSFEGSSTTKSEESITVSDKENETCLADQETGSKNIVSCDSNIGADKVEKKKQIQHVCQEMELKMCQSSENIILSDQIKDHNSSEARFSSKNIKDLRLASDNVSIDQFLRKRHEPESVSSDVSEQGSIHLEPLTPSEVLEYEATEILQKGSGDPSAKTDEVVSDQTDDIPGGNNPSTTEATVDLEDEKERS
Protein: Placenta-specific protein 1 (Q9HBJ0)
Organism: Homo sapiens (Human)
Function: May play a role in placental development.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Zona pellucida sperm-binding protein 3
- Histone acetyltransferase KAT5
- Bromodomain-containing protein 8
- Enhancer of polycomb homolog 2
- E1A-binding protein p400
- MBT domain-containing protein 1
- Transformation/transcription domain-associated protein
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein 3
- Enhancer of polycomb homolog 1
Sequence:
MKVFKFIGLMILLTSAFSAGSGQSPMTVLCSIDWFMVTVHPFMLNNDVCVHFHELHLGLGCPPNHVQPHAYQFTYRVTECGIRAKAVSQDMVIYSTEIHYSSKGTPSKFVIPVSCAAPQKSPWLTKPCSMRVASKSRATAQKDEKCYEVFSLSQSSQRPNCDCPPCVFSEEEHTQVPCHQAGAQEAQPLQPSHFLDISEDWSLHTDDMIGSM
Protein: Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Islet of Langerhans regenerating protein 3) (Lithostathine 3) (Pancreatitis-associated protein 2) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form] (O09037)
Organism: Mus musculus (Mouse)
Function: Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q06141}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250|UniProtKB:Q06141}.
Interaction partners:
- Regenerating islet-derived protein 3-beta
- Reg III delta
Sequence:
MLPHLVLNSISWMLLSCLLFVFQVQGEDFQKEVPSPRTSCPMGYKAYRSHCYALVMTPKSWFQADLVCQKRPSGHLVSILSGGEASFVSSLVNGRVDNYQDIWIGLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGHCGSLTASSGFLKWGDYYCDGTLPFVCKFKQ
Protein: Plastin-3 (T-plastin) (Q99K51)
Organism: Mus musculus (Mouse)
Function: Actin-bundling protein.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Coronin-1C
- Survival motor neuron protein
- F-actin-capping protein subunit beta
- Neurocalcin-delta
Sequence:
MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMVDGDRNKDGKISFNEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKNPAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLNVLEDLGEGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV
Protein: Meiotically up-regulated gene 131 protein (Q9USY0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated protein PB17E12.09
- Meiotic expression up-regulated protein 6
Sequence:
MDNQQRKVQGSSSNTFIKRAFQHLKSLFTVCFTGADYLESDIELICQNEIQPQGLEKLNADSSNFYCNSLTSNQSLTTSMEALDLSSSLTTPHADKLLKLSNLIAAKSFTTERKLSAAEFLDSREIHNPFTYGFLGILYGTSRTPYLHAQYANSFMSESAVPISIELNNREAKASMNLAEKNFPEGFEDFVSFLENPNIPLTVLLHHVMLYDLYSNNLKDAVWVAVTNYMKNLVGNYGYTELHIRAAQQMFGHPRFLLVHPEDIYCISGSSDWVCVSTQHFHCNIHVHSVSGNAIRKSRNPIIQDLSSICQNSTEFGWLALTHALRKKGAIFPIHAYLNFNAKLYEECIPPSILYFNKNDENINVGNIEDITNYMYETFINEASLCDKFMKRKHERIETPLSSQGREISNTLSRKRGAKGSNPFEIENMMPHA
Protein: Akirin (Protein bhringi) (Q9VS59)
Organism: Drosophila melanogaster (Fruit fly)
Function: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is required for embryonic development and for normal innate immune response. Acts as a regulator of embryonic myogenesis by bridging Twist (twi) with the SWI/SNF-like Brahma complex, promoting expression of twi-regulated genes during myogenesis. Effector of immune deficiency pathway (Imd) by acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel). Acts by bridging the NF-kappa-B factor Rel and the Brahma complex through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes. Not part of the Toll pathway. Required for the formation of the heart by promoting expression ot tinman (tin).
Subcellular location: Nucleus {ECO:0000269|PubMed:18066067, ECO:0000269|PubMed:22396663, ECO:0000269|PubMed:25180232}.
Interaction partners:
- Brahma-associated protein of 60 kDa
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-3
- Kinesin-like protein subito
- DNA methyltransferase 1-associated protein 1
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-1
- Proteasome subunit beta type-4
- Nuclear factor NF-kappa-B p110 subunit
Sequence:
MACATLKRALDWESMNQRPPKRRRCNPFGQAGSNAGPASPSRDGPSTSAGLPHTPSNRFAKDSTEPSPFSESSLAKMSPDKMAESLCNEIKRLHKRKQLPITSSALERMQDSESSGSEMGPESPRRPDSPQNLMRHGEKALFTFKQVQLICESMIKERENQLRERYESVLTTKLAEQYDAFVKFTYDQIQRRYEAAPSYLS
Protein: Scinderin (Adseverin) (Q7TQ08)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, podosome {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAQELQHPEFARAGKQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWQSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVATGIRDNERKGRSQLIVVEEGSEPPELMKVLGRKPELPDGDNDDDVIADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLPEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLHKMNYSANTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGADATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDTNSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCKTTRIQEGKEPDEFWNSLGGRGDYQTSPLLETQAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW
Protein: Sorting nexin-22 (Q96L94)
Organism: Homo sapiens (Human)
Function: May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q3UR97}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3UR97}; Cytoplasmic side {ECO:0000250|UniProtKB:Q3UR97}.
Interaction partners:
- Sorting nexin-24
Sequence:
MLEVHIPSVGPEAEGPRQSPEKSHMVFRVEVLCSGRRHTVPRRYSEFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQEVPKELLEFLRLRHFPTDPKASNWGTLREFLPGDSSSQQHQRPVLSFHVDPYVCNPSPESLPNVVVNGVLQGLYSFSISPDKAQPKAACHPAPLPPMP
Protein: Eukaryotic aspartyl protease family protein (Putative aspartyl protease) (Q9M8R6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine carboxypeptidase-like 43
- EP1-like glycoprotein 1
- Probable cysteine protease RD21B
- Ycf3-interacting protein 1, chloroplastic
- F3F9.4
- Lon protease homolog 2, peroxisomal
Sequence:
MDLRRRQWFLSAILLSAALLIDPQFSTAATASENLVFEVRSKFAGKRVKDLGALRAHDVHRHSRLLSAIDIPLGGDSQPESIGLYFAKIGLGTPSRDFHVQVDTGSDILWVNCAGCIRCPRKSDLVELTPYDVDASSTAKSVSCSDNFCSYVNQRSECHSGSTCQYVIMYGDGSSTNGYLVKDVVHLDLVTGNRQTGSTNGTIIFGCGSKQSGQLGESQAAVDGIMGFGQSNSSFISQLASQGKVKRSFAHCLDNNNGGGIFAIGEVVSPKVKTTPMLSKSAHYSVNLNAIEVGNSVLELSSNAFDSGDDKGVIIDSGTTLVYLPDAVYNPLLNEILASHPELTLHTVQESFTCFHYTDKLDRFPTVTFQFDKSVSLAVYPREYLFQVREDTWCFGWQNGGLQTKGGASLTILGDMALSNKLVVYDIENQVIGWTNHNCSGGIQVKDEESGAIYTVGAHNLSWSSSLAITKLLTLVSLLIPFFCNVAL
Protein: Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) (Q96KS0)
Organism: Homo sapiens (Human)
Function: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A. Target proteins are preferentially recognized via a LXXLAP motif. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions. Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Interaction partners:
- Hypoxia-inducible factor 1-alpha
- Endothelial PAS domain-containing protein 1
- E3 ubiquitin-protein ligase SIAH2
- Hypoxia-inducible factor 3-alpha
- Prolyl hydroxylase EGLN3
- Egl nine homolog 1
- Protein kinase C alpha type
- Histone H3.1t
- Histone H3.3C
- Histone H3.1
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (Q382V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GINS subunit domain-containing protein
- Cell division cycle 45
- DNA helicase
- Uncharacterized protein
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM5
- GINS subunit domain-containing protein
- DNA replication licensing factor MCM3
- Uncharacterized protein
- DNA polymerase II subunit 2
Sequence:
MNRHAFVEMTPLRPEPTDGSPTRGSQPAAVGQPQFFSRRDDMSYIWGTGIAVEVFRAEFQRFLETFEMPQDVGAAPGADAGAHRGGTRNFFLQELLRLRLQRRSLFEMDLQLFCRAAPRLYQQLIAHPVECLQMMESVAEEVSGRLVAAAGTHPSMPGEDEFILRIAPRNHPEITTLRGLSTRQLEQLVSLQGMVVRVSKIIPEIRVALFQCWSCNHTRHSVVDRGRIFEPTRCDSCGKQYSYRINHNLSVFEDKQLVRLQEAPEHLADGDTPVTMSVVVYGDFVDSIVPGDRVVVTGIYRAWPVRLNSNTRIIRSIFSTHVDAVHIEHRRAGRNAWADQQRQSAGEDEGLPEDPAVVARHNMFRHIAARPDIYDVILNSFARTIWGNEDVKRGILLQLFGGTRKELKCGSFRSEINIILCGDPGVAKSQLLTQVHEIAPRGVYTSGKGSSSAGLTAFVVQNNETGELVLEPGALVLSDRGLCCIDEFDKMNEATRSVLHEVMEQQTLSIAKAGIIAQLNARTSVLAAANPKESQWNVNLNVVENLQIEPTLLSRFDLIFLLMDRHDPAEDRRLASHVLSLFMETDESRASGNAAVPTDDDDDDVDNANGGGTSASRGHLATSRAPILLQHDGEVYLEGTEEKPYMPARVLSQYIAFARENIHPRLTGASHKQLAASYVEMRRARGSTRTVSATLRQLESMIRLAEARSKMRLGDTVSVEDVREAKWLISAALKEAATDPRTGRINLDVFNAPDPTRQTVEGSMLRLEKLIEQRYISAGHTTATVSELRLALNESFGSSMRPLSIVQFMELLALMVGGDHVKSFTASTVSFAGRLS
Protein: Membrane associated guanylate kinase, WW and PDZ domain containing 1 (A0A087WXD2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACFYLMGHNQTTTPAATATAPPPVHKVFRK
Protein: Uncharacterized protein (Q38AF1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVIHLCGLIIVPTVSSLITIIIITLLYYVHYMMCCSCCFFFFCMLVVAHTCLPSPLYASYTHRVGRSYIGGMSGWFGSPAPTAAPPPIPLNNPIGVTPQPPVLAVPAPQPVSLSVPKAVPIPQISALQQPLSSVDANLLMPLLSTPPLPLSTLPAVANESRLTAELPPTLSPGRSSEPLTVSLEGCGGVNVAAKAAILPVAALGGSEGQSGEQAAAVVGGAEQISPALGGVVTDGDTLAACRKSLPSYVVFGGARYNRVDVPPGAVKVLKRSNEKLISVAPRNTAKYMSHQLRLASAILRLDSRMRPPSSSFDAAARFSAVAPQDAGPLECDTFSLKNIWTIAYAGSVKDLHAFIELDGSAVSARGFVVYNRRHYGLKRLSEKFVLGLGQKATPLQYAAIAGHVDSVVLLLCMGAEDDSYPYLRDILGDELETTVKGVNAKLRSRRKHHCSRRKGKRGPAPTVAPPPPAAEEDCPAGTQP
Protein: Immunoglobulin superfamily member 21 (IgSF21) (Q7TNR6)
Organism: Mus musculus (Mouse)
Function: Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:28864826}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:28864826}.
Interaction partners:
Sequence:
MQAAPSLRRASCLLLAAILDLARGYLTVNIEPLPPVVAGDAVTLKCNFKTDGRMREIVWYRVTDGGTIKQKIFTFDAMFSTNYSHMENYRKREDLVYQSTVRLPEVRISDNGPYECHVGIYDRATREKVVLASGNIFLNVMAPPTSIEVVAADSPAPFSRYQAQNFTLVCIVSGGKPAPMVYFKRDGEPIDAVPLTELPAASSGPVQDSRPFRSLLHRDVDDTKMQKSLSLLDTEYRAGRPYTERPARSLTQDPSLFVQPTTENIPETVVSREFPRWVHSAEPVYFLRHSRTPGSDGTVEVRALLTWTLNPQIDNEALFSCEVKHPALSMPMQAEVTLVAPKGPKIMMTPSRARVGDTVRILVHGFQNEVFPEPMFTWTRVGSRLLDGSAEFDGKELVLERVPAELNGSMYRCTAQNPLGSTDTHTRLIVFENPNIPRGTEDSRGSASGPAGVRLTLVLALTVILELT
Protein: 9-beta-pimara-7,15-diene oxidase (EC 1.14.14.111) (Cytochrome P450 99A3) (Q0JF01)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in momilactone phytoalexins biosynthesis; acts as a multifunctional diterpene oxidase. Participates in the biosynthetic steps between 9-beta-pimara-7,15-diene and 3-beta-hydroxy-9-beta-pimara-7,15-dien-19,6-beta-olide. Catalyzes also consecutive oxidations at C19 of syn-stemod-13(17)-ene.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- Momilactone A synthase
- 4-coumarate--CoA ligase
Sequence:
MMEINSEATVTLVSVVTLPILLALLTRKSSSKKRRPPGPWNLPLVGGLLHLLRSQPQVALRDLAGKYGPVMFLRTGQVDTVVISSPAAAQEVLRDKDVTFASRPSLLVSEIFCYGNLDIGFAPYGAYWRMLRKLCTVELLSTKMVRQLAPIRDGETLALVRNIEAAAGGKKPFTLATLLISCTNTFTAKAAFGQACGGELQEQFLTALDEALKFSNGFCFGDLFPSLRFIDAMTGLRSRLERLRLQLDTVFDKIVAQCESNPGDSLVNVLLRIKDQGELDFPFSSTHVKAIILDMFTGGTETTSSTTEWLMSELMRNPEVMAKVQAEVRGVFDNKSPQDHEGLLENLSYMKLVIKETLRLNPVLPLLLPHLCRETCEIGGYEIVEGTRVLINSWAMARSPEYWDDAEKFIPERFEDGTADFKGSRFEYLPFGTGRRRCPGDIFAMATLELIVARLLYYFDWSLPDGMQPGDIDMELVVGATARRKNHLQLVASPYKPISMQS