wanglab/gogpt-training-data huggingface dataset:
Protein: Probable LRR receptor-like serine/threonine-protein kinase At4g30520 (EC 2.7.11.1) (Q8VYT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Senescence-specific cysteine protease SAG12
- DUF241 domain protein, putative
- AT4G23670 protein
- Uncharacterized protein AT4g35200
- Adenylate isopentenyltransferase 1, chloroplastic
- Defensin-like protein 99
Sequence:
MVVVTKKTMKIQIHLLYSFLFLCFSTLTLSSEPRNPEVEALISIRNNLHDPHGALNNWDEFSVDPCSWAMITCSPDNLVIGLGAPSQSLSGGLSESIGNLTNLRQVSLQNNNISGKIPPELGFLPKLQTLDLSNNRFSGDIPVSIDQLSSLQYLRLNNNSLSGPFPASLSQIPHLSFLDLSYNNLSGPVPKFPARTFNVAGNPLICRSNPPEICSGSINASPLSVSLSSSSGRRSNRLAIALSVSLGSVVILVLALGSFCWYRKKQRRLLILNLNDKQEEGLQGLGNLRSFTFRELHVYTDGFSSKNILGAGGFGNVYRGKLGDGTMVAVKRLKDINGTSGDSQFRMELEMISLAVHKNLLRLIGYCATSGERLLVYPYMPNGSVASKLKSKPALDWNMRKRIAIGAARGLLYLHEQCDPKIIHRDVKAANILLDECFEAVVGDFGLAKLLNHADSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGLRALEFGKTVSQKGAMLEWVRKLHEEMKVEELLDRELGTNYDKIEVGEMLQVALLCTQYLPAHRPKMSEVVLMLEGDGLAERWAASHNHSHFYHANISFKTISSLSTTSVSRLDAHCNDPTYQMFGSSAFDDDDDHQPLDSFAMELSGPR
Protein: Sticks and stones, isoform B (Q0E9F2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Kin of irre, isoform A
- Irregular chiasm C-roughest protein
- Verprolin 1, isoform G
- LD47926p
- Dreadlocks, isoform B
- Rolling pebbles, isoform B
- CIN85 and CD2AP related, isoform J
- Adapter molecule Crk
- Hibris, isoform B
Sequence:
MALQQQHQRHQQHQQHQQQQQQQQQQQHIKWQQHATKRRRCRQHWIKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALDFTAQPMPMAHLQPMTVTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSLPTATATLPRQPHGILKDPNRNKQQQQQQQQQQQQQQLQHQQQLLNASLVGVGVPVSAPLGSLQILNLPPASGGLGNNLLMTTNAFDPTTVGLSSFGAVSQAGGIPVAYTDADGHLV
Protein: Glucose transport transcription regulator RGT1 (Restores glucose transport protein 1) (P32862)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}. Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- General transcriptional corepressor CYC8
- Protein STD1
- Low glucose sensor SNF3
- SCF E3 ubiquitin ligase complex F-box protein GRR1
- General transcriptional corepressor TUP1
- High glucose sensor RGT2
- Protein MTH1
- Regulatory protein MIG1
- Carbon catabolite-derepressing protein kinase
- Low-affinity glucose transporter HXT1
Sequence:
MNELNTVSTNSSDSTKNGGTSNSPDDMDSAAAASHAIKKRTKASRACDQCRKKKIKCDYKDEKGVCSNCQRNGDRCSFDRVPLKRGPSKGYTRSTSHPRTNEIQDHNNSRSYNTFDNSNNTLNNNTGNSGDNGINSNTVPSTPSRSNSVLLPPLTQYIPQAGGIPPSFQNPAIQSTMPAGNIGQQQFWKVPYHEFQHQRKGSIDSLQSDISVRTLNPNEQLSYNTVQQSPITNKHTNDSGNANGSVTGSGSASGSGGYWSFIRTSGLLAPTDDHNGEQTRRSSSIPSLLRNTSNSLLLGGQPQLPPPQQQSQPQAHQQKLQQGQNLYSYSQFSQQQPYNPSISSFGQFAANGFHSRQGSVASEAMSPSAPAMFTSTSTNPVNVAQQTQRPQGQQVPQFSSELDGNKRRQSAPVSVTLSTDRLNGNENNNGEINNNNGSNNSGSSKDTSQHSQESVTTPAALEASSPGSTPQRSTKKRRKSYVSKKTKPKRDSSISITSKDSAHPMTTSSTIAYGQISDVDLIDTYYEFIHVGFPIIPLNKTTLTSDLLLVNTQPISNIHEVNSYVILWFRNSLELLVRVALKQKPGGKFFDNIVGVALSPSNDNNKAGFTTATARDDAEKTRRDSHNEVQDTLEVQSVFIAALNECFQKIVDIHPKFRENNDQISPKIKVIYLSTFILLNYILAFVGYDNSFVLGMSVTIFNEFKLYKLLLFPEPDINDVKPPVDEEVSTGNGNTKTSEFEIGSESAGHMNPSNSPNSMDENISHYSVLFKRLYVLLSVFDSLQSCAFGGPKLLNISIQGSTERFFSNDLGSKWCLEQSQLRLKSVLQSLKLGELMSELTRNRISMNGNRKPGFDITNSSSLLSEYVETQPLSVAQLFCKLLIGKHNFINCLLSLYDSEAGVYSDLTLDLSSKIADSLCSLISIILQVLTLILRLNPTNSIDFNYRPPNPPANNPTVQEGPSAMGSSPVAGNLSAAPPSEGNPDFYKKLLGLKQDTGTILSDLCRGIISPFAIAILHEVYNITELVKQMPTSLISIMMTATTTQNTQDTKKSQDLVMKLSNSMNEVVQITSVLTMIKPFKIFEHELNKPIMSLTGGLSSTTRNDVMWPKSGQGLRESSVMKTLLDERRTSGTQPTTAPVAAEEPRLENVALENFVSIGWKLLDDSELGWY
Protein: Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Q9Z2Q3)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Beta-glucuronidase
- Arylsulfatase B
- Alpha-L-iduronidase
- Extracellular link domain-containing 1
- Hyaluronan synthase 2
- Transforming growth factor beta-1 proprotein
- CD44 antigen
- Hyaluronan synthase 1
Sequence:
MRAGLGPIITLALVLEVAWASELKPTAPPIFTGRPFVVAWNVPTQECAPRHKVPLDLRAFDVEATPNEGFFNQNITTFYYDRLGLYPRFDAAGMSVHGGVPQNGSLCAHLPMLKEAVERYIQTQEPAGLAVIDWEEWRPVWVRNWQEKDVYRQSSRQLVASRHPDWPSDRIVKQAQYEFEFAARQFMLNTLRYVKAVRPQHLWGFYLFPDCYNHDYVQNWDSYTGRCPDVEVAQNDQLAWLWAENTALFPSVYLDKTLASSKHSRNFVSFRVQEALRVAHTHHANHALPVYVFTRPTYTRRLTELNQMDLISTIGESAALGSAGVIFWGDSVYASSMENCQNLKKYLTQTLVPYIVNVSWATQYCSWTQCHGHGRCVRRNPSASTFLHLSPSSFRLVPGRTPSEPQLRPEGELSEDDLSYLQMHFRCHCYLGWGGEQCQWNHKRAAGDASRAWAGAHLASLLGLVAMTLTWTL
Protein: Transcription factor AP-2 beta isoform (Transcription factor AP-2-beta isoform 2) (Q4TTV4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLVHAYSSTDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVSDPYSLNALHQPQQHPWGSRQRQDLQGTESGGLLPQPRASLPQLSGLDPRRDYSTVRRPDVLLHSTHHGLEAGMGDGLSLHGLAHGMDDVQAVEDLNGAMNTLDQSVIKKVPVPHKSVVSLMMNKDGLIGGISVNVNEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPTKAVSEYLNRQHTDPNELHSRKNMLLATKQLCKEFTDLLAQDRTPLGNSRPSPILEPGIQSCLSHFSFITHGFGSPAICAALTALQNYLTEALKGLDKMFLNNPTPNRHTPADGSKGGEKEEKHRK
Protein: Interleukin-8 (W6RYS0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSIRMSASLVVVLLALLTITEEMSLRGMGADLRCRCIETESRRIGKLIKKVEMFPPSSHCRDTEIIATLSKSGQEICLDVSAPWVKKVIEKMLANNK
Protein: AT3g16670/MGL6_12 (Pollen Ole e 1 allergen and extensin family protein) (Q9LUR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 71B17
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Uncharacterized protein
- Bnm1 like protein
- Peptide methionine sulfoxide reductase B6
- Ethylene-responsive transcription factor ERF016
- Exocyst subunit Exo70 family protein
- Mto 1 responding down 1
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- Protein EXORDIUM-like 1
Sequence:
MAVIKKHITFSLVLLCLIVVSPMANAQSGLGGINVPIINGVLFCTINGAPLNGTPAPAFANAVVQLQCGNLNRVVAETITNIAGLFTFSTNGIQISLPTLLNDCRIVVPTPRSSCDATLPSTGQLISQLNLVGSIVSGLLNIVAILPTGFIPTI
Protein: CREB regulated transcription coactivator 3 (H0YK64)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGN
Protein: L-asparaginase 1 (EC 3.5.1.1) (L-asparaginase I) (L-ASNase I) (L-asparagine amidohydrolase I) (P0A962)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Aspartate ammonia-lyase
- L-asparaginase 2
- Asparagine synthetase B
- Aspartate aminotransferase
- Isoaspartyl peptidase
- Nicotinamidase
- L-aspartate oxidase
- Argininosuccinate synthase
- Adenylosuccinate synthetase
- Aspartate carbamoyltransferase catalytic subunit
Sequence:
MQKKSIYVAYTGGTIGMQRSEQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTTKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMGGYATGNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPDD
Protein: Vomeronasal type-1 receptor 42 (Vomeronasal type-1 receptor A1) (Vomeronasal type-1 receptor A10) (Vomeronasal type-1 receptor A3) (Vomeronasal type-1 receptor A6) (Q8VBS7)
Organism: Mus musculus (Mouse)
Function: Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGDILFSSPQSMFSHTMNKNSILHTHSIIGKTFFSEIGIGISGNSFLLLVHILKFIRGHRPRLTDLPIGLLSLIHLLMLLVAAFIATDIFISRRGWDDIICKFLVYLYRVLRGFSLCTTSMLSILQAIILSPRSSCLAKFKHISPHHISGAILFLSVLYMLIGSQLLVSIIATPNLTMNDFIYVTQSCSILPLSYLMQSIYSTLLAIREFFLISLMVLSNWYMVALLSMHRKQTQHLHGTNLSPKKSPEQSATQTILMLISFFLLMTIYDTIVSCSRTMFLNDPTSYSIELFIMHIYATVSPFVFMSTEKHIVNFLRSLGKRVINFNLH
Protein: Cytochrome c oxidase subunit 5 (Cytochrome c oxidase polypeptide V) (P29505)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04037}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04037}; Matrix side {ECO:0000250|UniProtKB:P04037}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c1, heme protein, mitochondrial
- Probable cytochrome c oxidase subunit 6B
- Cytochrome c oxidase subunit 1+2
- Probable cytochrome b-c1 complex subunit 6
- Mitochondrial import inner membrane translocase subunit Tim23
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- Cytochrome c oxidase subunit VIb
- Zinc finger CHCC-type domain-containing protein
Sequence:
MSKIVKFLKELATPSHSMEFFHKPASNSLLDASELNFVRRNIKREDFGHEVLTGAFGTLKSPVIVESIFHSRIVACEGGDGEEHDILFHTVAEKKPTICLDCGQVFKLKHISSEGEVMYY
Protein: Probable ubiquitin fusion degradation protein C12B10.01c (HECT-type E3 ubiquitin transferase C12B10.01c) (EC 2.3.2.26) (Q10435)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Interaction partners:
- E3 ubiquitin-protein ligase ubr1
- Ubiquitin conjugation factor E4
Sequence:
MSVQAYTNTPNLPNLIHSESITNSPVFIPNLRSKSDNKHRLNTSEELPFTKKRRATKHFLKMEVSAKISEPPSSKSVEFGRHLNMRHDFSELLEQPLTTSKTRVFKSFNEKLKGKPQLVKSDKGVLPLNKQSDILNSYERVLSNASVDSALDKKAEVDIIPFDKSVMEPKNITFNDKSGLTKFGNSNSYETTYSDSSNYHTSTDSSQYNDQDDHVYDDTNDGTDDDINNNEYKDDESSSGSESYERDEDVDEEEEEDDDENNDEGDDEDENENDELRSENGSPNPSAAVINEQENMNMSGIEEYDETNLLNELGRIRRGNQFQSLASSILSSGNLENSDDEDVSLGPQTYRFNSSFHPFRSAFSAPGVQFGRLLEGIKDFSDPTVQMLSLQELSEAFAMSTEDMLVGLFSTDSYIAAFSEILSGRNYDFGEVSIQLMLSCTTCVSNMMEALPLCMAKIAYSPIVRILCERMFDMQYIDIAEQALGVLERLSKDFGICILEHRGMLAALQYFDFFYTTVQRTAISLAANCCKFLDESNASAAEEIIPLLSNILQSSDTIVVSKAYSCLETIIESLKTSPNIIETIISEDLITTIVNALTNSTSQNKSMHLQVQLLHIISSLCQSSSALILPFLNHNLPDVMYEMLCGIPPSDTSHQADMITMQSLYYCPIELIENLLRAITSLLPKNTSNLSDEFNTKLYRLNSILLTVVMDIYFIVPLHDIRSLAVTTALKMLCSIRENNLDGLVCSLPLSSFIASILNSRKSDNFLKRDALEMCLFLLEALPNVYSSLFIREGVVQEVGFLVRSTNADMKKIKLSISFSQNKSAARHEELKNLSTLKSLAKEFLSNYKEENLENSTLVQLKQLSKHLLSETKQDESFSELAKIFQEGSNITSHELLHSGLIHNLLLSLKKFGSSSLRTFLLAMNTCDEREVLEFGNGPLVSLIFCLQNLLSTVENFQLSTLPPDTENAVDHVFSRQFKLRLMALPGSRIRPPFRSLVVSINGLATIRTLDNYLHSRISVRNETGRRFSILREAGSLRESMSGSSRNSSGDYTDSMSQDAPNHTTEPSERRDSSTSSHFEEHFVFSLMGKKVPRNKTIFRILYEYIQLSDDHTLDDFWKTPVPIFYGEPDCIHNDMKGELNYENETEGFSINIREILDLLSILYYGIRDVHTLFPDKHFRGNIENILTDFSNWKLSAKLNRQLEEQQLVVHGCLPSWCISLTSAYPFLVPFETRYLLLQSTAFGLSRSVSFLLSRNPELSKNESSSILQFVSLHRQKIRISRKKIFNYALHLLATYAASENILEIEYEDEVGSGLGPTLEFYTSVSKEFTLNSLDIWRNDQPNSKFVYQASGLFPSPIPLLGSSPENERKISLFFALGQFVARSIYDSRIISIQFNPLFFARNIPLTISSVAKVDKGLANSLRYLEKLIPGKNPTNAETDIKLEDLHLDFTLPGFPSIELIPDGASTPVTTFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTSLQVLTEHELVTLFGTVDEDWSYATLMKSIVADHGYTMESPTIQRLLTLMSQMNFQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPEYSSSEVLGSRLSKAILEGQGSFHLS
Protein: Probable cadmium/zinc-transporting ATPase HMA1, chloroplastic (EC 7.2.2.12) (EC 7.2.2.21) (Protein HEAVY METAL ATPASE 1) (Q9M3H5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cadmium/zinc transport.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Copper transporter 2
- Probable magnesium transporter NIPA4
- Copper transporter 5
- Metal tolerance protein 1
- Copper transporter 4
- Copper transporter 3
- AT5g24690/MXC17_8)
- Metal transporter Nramp3
- Copper transporter 1
Sequence:
MEPATLTRSSSLTRFPYRRGLSTLRLARVNSFSILPPKTLLRQKPLRISASLNLPPRSIRLRAVEDHHHDHHHDDEQDHHNHHHHHHQHGCCSVELKAESKPQKMLFGFAKAIGWVRLANYLREHLHLCCSAAAMFLAAAVCPYLAPEPYIKSLQNAFMIVGFPLVGVSASLDALMDIAGGKVNIHVLMALAAFASVFMGNALEGGLLLAMFNLAHIAEEFFTSRSMVDVKELKESNPDSALLIEVHNGNVPNISDLSYKSVPVHSVEVGSYVLVGTGEIVPVDCEVYQGSATITIEHLTGEVKPLEAKAGDRVPGGARNLDGRMIVKATKAWNDSTLNKIVQLTEEAHSNKPKLQRWLDEFGENYSKVVVVLSLAIAFLGPFLFKWPFLSTAACRGSVYRALGLMVAASPCALAVAPLAYATAISSCARKGILLKGAQVLDALASCHTIAFDKTGTLTTGGLTCKAIEPIYGHQGGTNSSVITCCIPNCEKEALAVAAAMEKGTTHPIGRAVVDHSVGKDLPSIFVESFEYFPGRGLTATVNGVKTVAEESRLRKASLGSIEFITSLFKSEDESKQIKDAVNASSYGKDFVHAALSVDQKVTLIHLEDQPRPGVSGVIAELKSWARLRVMMLTGDHDSSAWRVANAVGITEVYCNLKPEDKLNHVKNIAREAGGGLIMVGEGINDAPALAAATVGIVLAQRASATAIAVADILLLRDNITGVPFCVAKSRQTTSLVKQNVALALTSIFLAALPSVLGFVPLWLTVLLHEGGTLLVCLNSVRGLNDPSWSWKQDIVHLINKLRSQEPTSSSSNSLSSAH
Protein: Protein kinase superfamily protein (F4I8V6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable disease resistance protein At1g62630
- Probable disease resistance protein At1g12290
- Disease resistance RPP8-like protein 3
- Probable disease resistance protein At1g59620
- Putative disease resistance protein At3g14460
- Putative disease resistance RPP13-like protein 2
- Disease resistance protein At4g27190
- Putative disease resistance RPP13-like protein 1
Sequence:
MSRVLISKIVGKQTQSLVSNQKDRVSQWGSYRTAFTAALRSPQLRTYSSSGRIPSNVYCTFAFRDLKGSFLSNHLSRSYTTAPARNVVSHHAQIAWRRLHYKYSERISTIAQAFSLSLTRSHLLIPGIVAVTCGQVAWAQRAPGSGINHYASDKSLYTRAKNGPIFLSSLLFSVIEGFILIGRAFYIACLFTPTILMGLVVESCGPRFRKIWLEMVHRTLERAGPAFIKWGQWAATRPDLFPKDLCSQLSKLHSNAPEHSFAYTKKTIEKAFGRKLSEIFEEFDEVPVASGSIAQVHRASLRFQYPGQKSKSSLVAVKVRHPGVGESIRRDFVIINLVAKISTLIPALKWLRLDESVQQFGVFMLSQVDLAREASHLSRFIYNFRRWKDVSFPKPVYPLVHPAVLVETYEHGESVARYVDGMEGHEWIKTRLAHIGTHALLKMLLVDNFIHADMHPGNILVRKKASRGGLFKTKKPHIVFLDVGMTAELAKNDRENLLDFFKAVARRDGRTAAERTLKLSRKQNCPNPEAFIEEVEEAFKFWGTPEGDLVHPADCMHELLEKVRRHRVNIDGNVCTVMVTTLVLEGWQRKLDPGYDVMHTLQTMVLKTDWAKSLSYTVDGLMAP
Protein: T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) (P20963)
Organism: Homo sapiens (Human)
Function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P24161}; Single-pass type I membrane protein.
Interaction partners:
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Natural cytotoxicity triggering receptor 1
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 epsilon chain
- Tyrosine-protein kinase ZAP-70
- Natural cytotoxicity triggering receptor 3
- Low affinity immunoglobulin gamma Fc region receptor III-B
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD8 alpha chain
- Tyrosine-protein kinase SYK
Sequence:
MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR
Protein: Aconitate hydratase A (Aconitase) (EC 4.2.1.3) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (IRP-like) (Probable 2-methyl-cis-aconitate hydratase) (EC 4.2.1.99) (RNA-binding protein) (Q937N8)
Organism: Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2S,3R)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity).
Interaction partners:
Sequence:
MNSANRKPLPGTKLDYFDARAAVEAIQPGAYDKLPYTSRVLAENLVRRCDPATLTDSLLQLVGRKRDLDFPWFPARVVCHDILGQTALVDLAGLRDAIADQGGDPAKVNPVVPVQLIVDHSLAVECGGFDPDAFAKNRAIEDRRNEDRFHFIDWTKQAFKNVDVIPPGNGIMHQINLEKMSPVIHADNGVAYPDTCVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIVGVELTGKRQPGITATDIVLALTEFLRKEKVVGAYLEFRGEGASSLTLGDRATISNMAPEYGATAAMFFIDEQTIDYLRLTGRTDEQLKLVETYARTAGLWADSLKNAEYERVLKFDLSSVVRNMAGPSNPHKRLPTSALAERGIAVDLDKASAQEAEGLMPDGAVIIAAITSCTNTSNPRNVIAAALLARNANARGLARKPWVKSSLAPGSKAVELYLEEANLLPDLEKLGFGIVAFACTTCNGMSGALDPKIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGTDQDGKPVYLKDIWPSDEEIDAIVAKSVKPEQFRKVYEPMFAITAASGESVSPLYDWRPQSTYIRRPPYWEGALAGERTLKALRPLAVLGDNITTDHLSPSNAIMLNSAAGEYLARMGLPEEDFNSYATHRGDHLTAQRATFANPTLINEMAVVDGQVKKGSLARIEPEGKVVRMWEAIETYMDRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEVIVAEGFERIHRTNLIGMGVLPLEFKPGVNRLTLGLDGTETYDVIGERQPRATLTLVVNRKNGERVEVPVTCRLDSDEEVSIYEAGGVLHFAQDFLESSRATA
Protein: Carboxylesterase/phospholipase LipF (EC 3.1.1.1) (EC 3.1.4.3) (O06350)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. Has no enzyme activity on triacylglycerides or p-nitrophenyl esters (p-NP) with long fatty acids (tricaprin, p-NP caprylate, or p-NP caprate); experiments performed with enzyme missing the first 97 residues. Has phospholipase C activity, making 1,2-DAG phosphocholine; experiments performed with enzyme missing the first 97 residues.
Subcellular location: Secreted, cell wall {ECO:0000305|PubMed:18535356}. Note=Detected by antibodies in a wild-type strain and upon expression of a probably truncated form in M.smegmatis. {ECO:0000269|PubMed:18535356}.
Interaction partners:
- Triacylglycerol lipase
- Putative hydrolase LipZ
- Esterase LipC
- Putative fatty-acid--CoA ligase FadD21
Sequence:
MSSYYARRPLQSSGCSNSDSCWDGAPIEITESGPSVAGRLAALASRMTIKPLMTVGSYLSPLPLPLGFVDFACRVWRPGQGTVRTTINLPNATAQLVRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNALSGFAESPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLALALAQRLQCDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMVDGRPEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI
Protein: SNARE protein, putative (Q8I3G6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Syntaxin, Qa-SNARE family
- Alpha-soluble NSF attachment protein, putative
- Protein transport protein SEC22
- Syntaxin, Qa-SNARE family
- Syntaxin, Qa-SNARE family
- Syntaxin, Qa-SNARE family
- SNARE protein, putative
- SNARE protein, putative
- Vesicle transport v-SNARE protein VTI1, putative
- Vesicle transport v-SNARE protein, putative
Sequence:
MDLWDKDYQKALQTGKDIKKLLKQSEKEKKKAKNRAILRGKITEFNQSVKFLVHQLSNDYIKNDKHFIKNETKYMNKVSALEKVKKEIGTLYEDYASTNEGEISLNMNMELLNEFENEENTYLNDLNKEELLLKQNKLMKLQDEQLNFLEGTTHNLKNISYNINSEIQVHNELLDDIDRDMDETNNLLDRNRNIFERVTSNTSNYFLYFLIVILTASLIFFIMIL