wanglab/gogpt-training-data huggingface dataset:
Protein: Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) (P55264)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Subcellular location: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P55263}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P55263}.
Interaction partners:
- Adenosine deaminase
- Adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Adenylate kinase 2, mitochondrial
- 5'-nucleotidase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- AMP deaminase 2
- AMP deaminase 3
- Ectonucleoside triphosphate diphosphohydrolase 1
Sequence:
MAAADEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLERNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFISQFFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFTQGRDDTIVAAENDVTAFPVLDQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
Protein: Transmembrane protein 119 (Osteoblast induction factor) (OBIF) (Q8R138)
Organism: Mus musculus (Mouse)
Function: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20025746}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:21239498}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21239498}. Secreted {ECO:0000250|UniProtKB:Q4V9L6}.
Interaction partners:
- P2Y purinoceptor 12
- Triggering receptor expressed on myeloid cells 2
- Olfactomedin-like protein 3
- Macrophage colony-stimulating factor 1 receptor
- Allograft inflammatory factor 1
- CX3C chemokine receptor 1
- Fc receptor like 2
- Sal-like protein 1
- Cystatin-F
- Probable G-protein coupled receptor 34
Sequence:
MVPWFLLSLLLLARPVPGVAYSVSLPASFLEDVAGSGEAEGSSASSPSLPPPGTPAFSPTPERPQPTALDGPVPPTNLLEGIMDFFRQYVMLIAVVGSLTFLIMFIVCAALITRQKHKATAYYPSSFPEKKYVDQRDRAGGPRTFSEVPDRAPDSRHEEGLDTSHQLQADILAATQNLRSPARALPGNGEGAKPVKGGSEEEEEEVLSGQEEAQEAPVCGVTEEKLGVPEESVSAEAEGVPATSEGQGEAEGSFSLAQESQGATGPPESPCACNRVSPSV
Protein: Multiprotein-bridging factor 1 (O94700)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein RACK1
- TATA-box-binding protein
Sequence:
MSDWDTVTKIGSRAGPGARTHVAKTQSQINSARRAGAIVGTEKKYATGNKSQDPAGQHLTKIDRENEVKPPSTTGRSVAQAIQKGRQAKGWAQKDLSQRINEKPQVVNDYESGRAIPNQQVLSKMERALGIKLRGQNIGAPLGGPKKK
Protein: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (Q8BGV7)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WZ19}.
Interaction partners:
- Cullin-3
- UBX domain-containing protein 7
- FAS-associated factor 1
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
- Aspartate beta-hydroxylase domain-containing protein 1
- E3 ubiquitin-protein ligase ARIH1
- Rho-related GTP-binding protein RhoN
- Potassium channel tetramerisation domain containing 17
- Serine/threonine-protein kinase TAO2
Sequence:
MSAEASGPAPAAAECLESPSPSSVEPGSPSYSLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESARELGELLGEARYYLVQGLIEDCQLALQQKREKLSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENSRGPDLALLEATGGAAGGGGAGRGDDEENREHRVRRIHVRRHITHDERPHGQQIVFKD
Protein: Uncharacterized protein (Q57X28)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Iron-sulfur assembly protein 2
- Iron-sulfur cluster assembly protein, putative
- Cytochrome oxidase assembly protein, putative
Sequence:
MMRFFVWIRCLGLPSRQSIYRSGCAHASTSAIAEMTANGVANSPVMPYKSTHKGKGVGDPNRKGSSVVGAPSGGTDQCQQNLAGSRSSCAEDGKAAPSRPLSPLQRRQLMMRHKAAFTLTPQAIRRVRYLLSQYQQNNEGEGPIPDGIRVSVRRRGCSGYSYTVNYNYPSKGDETGAPVNCNSQNKNKDEGGSSEVSFMSAVGGMAPGGDVVVVQNGIKVVVDSNALFYVIGTEMDYVVRNVEEKFTFRNPNQKYSCGCEESFMPFDADEQL
Protein: 3'-5' exonuclease (EC 3.1.-.-) (Werner Syndrome-like exonuclease) (Q84LH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exonuclease that digests recessed strands of DNA duplexes in the 3' to 5' direction but hardly single-stranded DNA or blunt-ended duplexes. Also able to digest 3'-protruding strands and 3'-recessed strand termini of duplexes containing mismatched bases.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Uncharacterized protein At5g41620
- ATP-dependent DNA helicase 2 subunit KU70
- ATP-dependent DNA helicase Q-like 3
- Ribonuclease H-like superfamily protein
- Putative non-LTR reverse transcriptase
- Reverse transcriptase-like protein
- Putative reverse transcriptase/RNA-dependent DNA polymerase
- Protein RISC-INTERACTING CLEARING 3'-5' EXORIBONUCLEASE 2
- Putative reverse transcriptase
- Glucan endo-1,3-beta-glucosidase 9
Sequence:
MSSSNWIDDAFTEEELLAIDAIEASYNFSRSSSSSSSAAPTVQATTSVHGHEEDPNQIPNNIRRQLPRSITSSTSYKRFPLSRCRARNFPAMRFGGRILYSKTATEVDKRAMQLIKVLDTKRDESGIAFVGLDIEWRPSFRKGVLPGKVATVQICVDSNYCDVMHIFHSGIPQSLQHLIEDSTLVKVGIGIDGDSVKLFHDYGVSIKDVEDLSDLANQKIGGDKKWGLASLTETLVCKELLKPNRIRLGNWEFYPLSKQQLQYAATDAYASWHLYKVLKDLPDAVSGS
Protein: Evasin P675 (A0A0K8R374)
Organism: Ixodes ricinus (Common tick) (Acarus ricinus)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MEVKTFAFLQIAVIIALGLHLAPAGSNQLSGPQSSANSNDAVFCDTNCTQGTDGAWSGCRGDCFCVHVGNSTEGRCIELIGDFDYSTPGAED
Protein: Arginase (EC 3.5.3.1) (P00812)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Ornithine aminotransferase
- Ornithine carbamoyltransferase
- Ornithine decarboxylase
- Urea amidolyase
- Argininosuccinate lyase
- Arginine biosynthesis bifunctional protein ArgJ, mitochondrial
- Spermidine synthase SPE3
- Acetylornithine aminotransferase, mitochondrial
- Proline dehydrogenase, mitochondrial
- Protein ARG5,6
Sequence:
METGPHYNYYKNRELSIVLAPFSGGQGKLGVEKGPKYMLKHGLQTSIEDLGWSTELEPSMDEAQFVGKLKMEKDSTTGGSSVMIDGVKAKRADLVGEATKLVYNSVSKVVQANRFPLTLGGDHSIAIGTVSAVLDKYPDAGLLWIDAHADINTIESTPSGNLHGCPVSFLMGLNKDVPHCPESLKWVPGNLSPKKIAYIGLRDVDAGEKKILKDLGIAAFSMYHVDKYGINAVIEMAMKAVHPETNGEGPIMCSYDVDGVDPLYIPATGTPVRGGLTLREGLFLVERLAESGNLIALDVVECNPDLAIHDIHVSNTISAGCAIARCALGETLL
Protein: Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) (A0A8I6AVM6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR023869}.
Interaction partners:
Sequence:
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQAKVWREACPSGPGKERGRAPARNCKVRGEGERKERSADCKH
Protein: Dynein axonemal assembly factor 4 (A0A0S2Z5Z4)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, neuron projection {ECO:0000256|ARBA:ARBA00004487}. Dynein axonemal particle {ECO:0000256|ARBA:ARBA00024190}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEFCSLEGIECQASEPKLSHHIPSDLHVYIQMA
Protein: Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) (Q9BWS9)
Organism: Homo sapiens (Human)
Function: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
Subcellular location: Secreted {ECO:0000269|PubMed:16357325}. Lysosome {ECO:0000269|PubMed:16357325}.
Interaction partners:
- Stabilin-1
- WD repeat-containing protein 90
- Prosaposin
- Chitinase-3-like protein 2
Sequence:
MRTLFNLLWLALACSPVHTTLSKSDAKKAASKTLLEKSQFSDKPVQDRGLVVTDLKAESVVLEHRSYCSAKARDRHFAGDVLGYVTPWNSHGYDVTKVFGSKFTQISPVWLQLKRRGREMFEVTGLHDVDQGWMRAVRKHAKGLHIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVVQVAKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLAEALHQARLLALLVIPPAITPGTDQLGMFTHKEFEQLAPVLDGFSLMTYDYSTAHQPGPNAPLSWVRACVQVLDPKSKWRSKILLGLNFYGMDYATSKDAREPVVGARYIQTLKDHRPRMVWDSQASEHFFEYKKSRSGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL
Protein: Large ribosomal subunit protein eL32 (60S ribosomal protein L32) (Q6QAT0)
Organism: Sus scrofa (Pig)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62910}.
Interaction partners:
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS2
Sequence:
MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE
Protein: DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4) (P41139)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
Subcellular location: Nucleus.
Interaction partners:
- Oligodendrocyte transcription factor 1
- Oligodendrocyte transcription factor 2
- Achaete-scute homolog 1
- Transcription factor 12
- Transcription factor E2-alpha
Sequence:
MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPALLRQPPPPAPPLHPAGACPVAPPRTPLTALNTDPAGAVNKQGDSILCR
Protein: SNF4/AMP-activated protein kinase gamma subunit (Q7KNS9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EDDSQIFVKFFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNGVRAAPLWDSEKQQFVGMLTITDFIKILQMYYKSPNASMEQLEEHKLDTWRDVLHNQVMPLVSIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKRILRFLFLYINELPKPAYMQKSLRELKIGTYNNIETADETTSIITALKKFVERRVSALPLVDSDGRLVDIYAKFDVINLAAEKTYNDLDVSLRKANEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRKVIGIISLSDILLYLVLRPSGEGVGGSESSLRASDPVLLRKVAEVEIPATAAAATTTTPPRSPSAGSGNRSLIEDIPEEETAPARSDDADSDNNKSASEDKANNNQHDQTTTAATANGDSNNSPVEVSFADEAQEEEAADQVERSNCDDDDQPALAEIERKNASMDDDEDDGMSSAVSAASALGQSLTPAAQEMALVSE
Protein: Transcription factor 21 (Q498R2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Wilms tumor protein homolog
- Transcription factor 12
- T-box transcription factor 18
- Periostin
Sequence:
MSTGSLSDVEDLQEVEMLDCDSLKVDSNKEFGTSNESTEEGSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDLKEVVTASRLCGTTAS
Protein: RRM domain-containing protein (Q388L9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEHKAHPGSFGVVRDRRINNPSEEAQKRWALETPPMFAQESPKEELPPMEDLAPSRAAVAAQRVSSTTQPAAEAAVEKPADSGAPAVPDAEAETRRPKSFAEAIKLGKQVGSNASQVAPRLVVAKGVKDHAEEPPVRVKASEPQREGAKALTKDSTGAKKGATAKKRDGSEKNGKEASDRSSGKPNGREGPNRSKGKDAEGRTLSRFVVFYDVIVKGLPPTATEQTVRDLVEPMAPVKLVKLLSQNDKKDTNVIRTFSFVQLDHDAIKEAGGNVKATVAKLLESSKGKKGSGGSRIQIDEVREKYTAAPAQTSGEAANADCSQ
Protein: enoyl-CoA hydratase (EC 4.2.1.17) (E9KL44)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFYQ
Protein: Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) (P14927)
Organism: Homo sapiens (Human)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00128}; Matrix side {ECO:0000250|UniProtKB:P00128}.
Interaction partners:
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 5A, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Cytochrome b
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- Cytochrome b-c1 complex subunit 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Cytochrome c oxidase subunit 5B, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK
Protein: Runt-related transcription factor (A0A0D9SEN7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009374}.
Interaction partners:
Sequence:
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY
Protein: Transmembrane 9 superfamily member 5 (Endomembrane protein 11) (Transmembrane nine protein 5) (AtTMN5) (F4HW17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:P32802}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g74900, mitochondrial
- UDP-galactose/UDP-glucose transporter 5B
- Nuclear intron maturase 4, mitochondrial
- Nuclear intron maturase 1, mitochondrial
- Nuclear intron maturase 2, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 2
- Aspartic proteinase 39
Sequence:
MAQFLLTVLQVLLALTFWIGIGSGSSNHYNAGDHVPLFVNKVGPLHNPSETYQYYDLPFCRRGPVIEKQETLGEVLNGDRLMSSLYKLKFREDKTHFVLCRKRLTSSDIARFRDIIAQDYYFQMYYDDLPLWGFVGKVEGDYFGQGEKHTKYYIFSHLKFNVLYNADKVIEINSFSDPSYMVDISENTEIDVQFTYSVSWNLTSERSETRMNKYSRASFHPISQKIHFFSFLNSITVVVLLIGLISFLFMRHLKNELRSYSIGDEEERKEAGWKLVHSDVFRCPRNISWLCAILGTGTQLLILIIALFALAFTGFLYPYNRGMLLTSLVIMYTLTSIVAGYTSTSFHSQFEGNKQKRSVRLAGILYPVPFFIILSVLNTVAITYGATAALPFGTIVIIILIFTLLNIPFLMLGGVLGNRFGLLEFQPPSAVKRNPREIPPQNWYRRKLYQVFLGGFVPFSAVVLEWHQLYASLWGFKIYTSPGIMLFTFIVLIFLSSSVGIILTYIQLSGEDHEWWWRSILCGGFTAVFMYGYGVLFYLRSDMTGFLQLSFYLGYTALLCYALFLVLGTISFLASLMFIRHIYRSVKLE
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (A0A087WZJ6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKVCGFRCSGVSFILSA
Protein: LD19311p (Q9W0B2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVLSKPLYSLFGTYLEQLFNHPVRTKSITACVLATSANVTSQRLAGAKTLNQQSVFAYGLFGLIFGGSVPHYFYTTVERLFSQDVRFRRFFLFLSERLVYAPIYQALSLFFLALFEGKSPSTALKNVEKLYWPLLKANWQYLSVFVYLNFAYVPPMFRSISMAIISFIWVVYIAQKRRRFQDKLAAKEAAK
Protein: Placenta-specific gene 8 protein (Onzin) (Protein C15) (Q9JI48)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAQAPTVIVTQPGFVRAPQNSNWQTSLCDCFSDCGVCLCGTFCFTCLGCQVAADMNECCLCGTTVAMRTLYRTRYGIPGSICDDYMVTLFCPVCSVCQLKRDINRRRAMNAF
Protein: Uncharacterized protein (Q388F2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Intraflagellar transport protein 80
- Uncharacterized protein
- OCRE domain-containing protein
- Intraflagellar transport protein A1
- WD repeat-containing protein 19
- Intraflagellar transport protein-like protein
- IFT80/172/WDR35 TPR domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Intraflagellar transport complex B protein 46 C terminal
Sequence:
MSVKLPHVSVQYQSHQHCQCDFCNSRRNLNAKKSALMTTVSHLREQQALHNCCCQCHDSLSQRNYDRKPQEPSFELDDPEHHPNQTELNAKMGRNGLQHGGEYTIPPGVRAAQQCLLNGSNGMAKTREEQEKDAMDDLDRLERLLVLEHKSRVKAAADAENFETLKRTGKGPRPIPFDAPEEQVRVKSATPPQGTIVMPGTVREAYDAAHRCSVTPPPHCEDSHRLQHVIEKVRTVARDPANRDNAAALGAVLHRQCGAGTPPVSREGVATPPIEGMKTIGTLNTYGPRPEGAGVVWCRGLNAVVDDGIGTSAALGNTDNRDLWKATLLKNQPTTTN
Protein: Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Ubiquitin-specific-processing protease testis) (UBP-t) (Q5U349)
Organism: Rattus norvegicus (Rat)
Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (By similarity). Has no deubiquitinase activity against p53/TP53 (By similarity). Prevents MDM2-mediated degradation of MDM4 (By similarity). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O88623}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12107281}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000269|PubMed:12107281}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:12107281}. Membrane {ECO:0000250|UniProtKB:O88623}; Peripheral membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O88623}. Note=Predominantly expressed at membranes. {ECO:0000250|UniProtKB:O88623}.
Interaction partners:
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- E3 ubiquitin-protein ligase Mdm2
- Zinc finger-containing ubiquitin peptidase 1
- OTU domain-containing protein 3
- Ubiquitin carboxyl-terminal hydrolase 28
Sequence:
MSQLSSTLKRYTESSRYTDAPYAKSGYGTYTPSSYGANLAASFLEKEKLGFKPVSPTSFLPRPRTYGPSSILDCDRGRPLLRSDITGGSKRSESQTRGNERPSGSGLNGGSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDLARDFSSLRTSDSYRTSDGYRASDGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRKGSAPQVLTQAPPSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSRSTSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVAARPKPSPESLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
Protein: Toxin Tppa1 (C0HLZ0)
Organism: Tityus pachyurus (Colombian scorpion)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Subcellular location: Secreted {ECO:0000269|PubMed:35024608}.
Interaction partners:
Sequence:
KDGYLVGNDGCKYSCLTRPGHYCASECSRVKGKDGYCYAWMACYCYSMPDWVKTWSRSTNRCGRGK
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q6TLD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNVQPSNPNNPIVFFDVSIGGQEVGRMKIELFADIVPKTAENFRQFCTGEFKKDGVPVGYKGCTFHRVIKDFMIQGGDFVNGDGTGICSIYRGPFADENFRMKHSGPGLLSMANSGPGTNGCQFFITCTKCDWLDGKHVVFGKVVDGLLVMRKIENVPTGPNNKPKLPIVVSQCGEM