wanglab/gogpt-training-data huggingface dataset:
Protein: Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) (P04076)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Protein ARG5,6
- Argininosuccinate synthase
- Arginine biosynthesis bifunctional protein ArgJ, mitochondrial
- Histidine biosynthesis trifunctional protein
- Arginase
- Ornithine carbamoyltransferase
- Amino-acid acetyltransferase, mitochondrial
- Carbamoyl phosphate synthase arginine-specific large chain
- Acetylornithine aminotransferase, mitochondrial
- Adenylosuccinate lyase
Sequence:
MSDGTQKLWGGRFTGETDPLMHLYNASLPYDYKMYKADLEGTKVYTAGLQKLGLLTETELAKIHEGLAEIKKEWDADKFVRHPNDEDIHTANERRLGELIGRDIAGKVHTGRSRNDQVVTDLRIYCRDIVNDTLFPALKGLVEVLIKRAEGEIDVLMPGYTHLQRAQPIRWSHWLSSYATYFTEDYKRLGQILHRLNQSPLGAGALAGHPYGIDREFLAEGLGFNSVIGNSLVAVSDRDFIVELMFWGTLFMNHISRFAEDLIIYCTAEFGFIQLSDAYSTGSSLMPQKKNADSLELLRGKSGRVFGDLTGFLMSLKGIPSTYDKDMQEDKEPLFDCLTTVEHSMLIATGVISTLTVNKEKMEAALTMDMLATDLADYLVRKGVPFRETHHISGECVATAERLGLSGIDKLTLEQYQKIDSRFGQDLFETFNFEQSVERRDATGGTAKSAVLKQLDNLKSQLN
Protein: F-box protein FBX14 (Transport inhibitor response 1-like protein) (TIR1-like protein) (Q8RWQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- SKP1-like protein 1A
- Auxin transporter protein 1
- POLAR LOCALIZATION DURING ASYMMETRIC DIVISION AND protein
- Auxin-responsive protein IAA7
Sequence:
MTEEDSSAKMSEDVEKYLNLNPPCSSSSSSSSAATFTNKSRNFKSSPPPCPDHVLENVLENVLQFLTSRCDRNAVSLVCRSWYRVEAQTRLEVFIGNCYSLSPARLIHRFKRVRSLVLKGKPRFADFNLMPPNWGAQFSPWVAATAKAYPWLEKVHLKRMFVTDDDLALLAESFPGFKELTLVCCEGFGTSGIAIVANKCRQLKVLDLMESEVTDDELDWISCFPEGETHLESLSFDCVESPINFKALEELVVRSPFLKKLRTNRFVSLEELHRLMVRAPQLTSLGTGSFSPDNVPQGEQQPDYAAAFRACKSIVCLSGFREFRPEYLLAISSVCANLTSLNFSYANISPHMLKPIISNCHNIRVFWALDSIRDEGLQAVAATCKELRELRIFPFDPREDSEGPVSGVGLQAISEGCRKLESILYFCQNMTNGAVTAMSENCPQLTVFRLCIMGRHRPDHVTGKPMDDGFGAIVKNCKKLTRLAVSGLLTDEAFSYIGEYGKLIRTLSVAFAGNSDKALRYVLEGCPKLQKLEIRDSPFGDVGLRSGMHRYSNMRFVWLSSCLISRGGCRGVSHALPNVVVEVFGADGDDDEDTVTGDYVETLYLYRSLDGPRKDAPKFVTIL
Protein: Phosphotransferase (EC 2.7.1.-) (Q19440)
Organism: Caenorhabditis elegans
Interaction partners:
- Glucose-6-phosphate isomerase
- phosphoglucomutase
- ATP-dependent 6-phosphofructokinase 1
- Fructose-1,6-bisphosphatase isozyme 2
- Phosphoglucomutase-2
- ATP-dependent 6-phosphofructokinase 2
- Probable phosphomannomutase
- Probable ADP-dependent glucokinase
- Glucosamine 6-phosphate N-acetyltransferase
- Probable mannose-6-phosphate isomerase
Sequence:
MSSIVCHPILDSQNGIATDAVIKKQRPPPLVLSRPKDLIQEACQRLVLSDQQLRRIMQSMEKSMEQGLATSTKKVAVKMLPTYVDSVPNGTESGDFLALDLGGTNFRVLHIKLQGKETKMTGKIFRVPESIMRGTGEALFDHIAGCMAKFMGENDLKDAQKLPLGFTFSFPCEQEGLTKGKLVTWTKGFKASGVEGVDVVTLLHEACHRRKDIDIDVVALLNDTVGTLMACAFQENSCQIGVIVGTGTNACYMERLDRIPKLAGYVDEHGVTPEEMIINTEWGAFGDDGALDFLRTEWDEVVDRESINPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGNSDAISVPHCFPTKFVSEIDSDLLEDDDRTFQKTYQILEDIGVEMITANDCANVAYVCSLISTRAAHLTAAGIAMLLNRMNKKHVTVGVDGSVYRFHPTYPTLLDAKIGELIVGDIEYKLMLSEDGSGRGAALVAAVATRLKEEKLAASLSSSSSNQ
Protein: Acidic phospholipase A2 5 (svPLA2) (EC 3.1.1.4) (PA2-Vb) (PLA2-V) (Phosphatidylcholine 2-acylhydrolase) (P82896)
Organism: Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri)
Function: Snake venom phospholipase A2 (PLA2) that inhibits platelet aggregation induced by ADP, arachidonic acid and PAF (Ref.1). Acts in a enzymatic independent manner on a proteinase-activated receptor (PAR1, F2R) to evoke calcium release through the inositol 1,4,5-trisphosphate receptor (ITPR1, IP3R) and induces mouse aorta contraction. PAR1, phospholipase C and IP3R inhibitors suppress PA2-induced aorta contraction. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular location: Secreted {ECO:0000269|PubMed:25447533, ECO:0000269|Ref.1}.
Interaction partners:
Sequence:
NLMQFELLIMKVAGRSGIVWYSDYGCFCGKGGHGRPQDATDRCCFVHDCCYGKVTECDPKMDFYRYSSNNGDIVCEANNPCTKEICECDKAAAICFRDNKDTYDNKYWNIPMEGCQEESEPC
Protein: 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) (P43686)
Organism: Homo sapiens (Human)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Proteasome subunit beta type-2
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome regulatory subunit 4
- 26S proteasome regulatory subunit 10B
- Proteasome subunit beta type-3
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 5
Sequence:
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Protein: ADP-ribosylation factor (Q38FV2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Conserved oligomeric Golgi complex subunit 8
- Small GTP-binding protein RAB6, putative
- ADP-ribosylation factor-like protein, putative
- Conserved oligomeric Golgi complex subunit 6
Sequence:
MFSLVRGLYSSIFADDTRKVLIVGLESSGKTTLSEQLKHMYATESSKNGANSSTTEENSGDATASEVNYNFPTPAPVESLRKKIRPTTGLNRSSVTHVTTPPQHETPNVSLTPLTTPLILWDIGGSLRPLWGNFFGTCHGVIFVVDSTLGEATSNGCSEGGRKTSPDQVGTSEDDESDVGAQPNSPIGDVREGERSQFLRKLYAKDALILRQMFSHPLLAGAPLLIVSNKVDAANHHTLVEIQDALRLVDVALMDEFYADDCVVGEPVYGELHRNGEGDYEGPPDRSAYDKLSNEKSFGGVATPPPGSSGIGNRVMRLVEMSALHGTGVVDGMNWLVAQMRDSGRQPLPDDGK
Protein: Alpha-mannosidase (EC 3.2.1.-) (Q75WP2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFKLFRRGSARCIGLLSAFVTILLCLYYISIGQPNPTPISETGAPSAALRGSPLSGLTGFSVGGGSSSIIHQQKQQLVIASNQKKSSETKSAQTSVSPEEQSEEQYTNSNWGDKCYELIQSNTNITASEEHSKFDFQPEWMRSKEYWDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEMESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAYRSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDVDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQPELAAALLPLVKLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTFRSEV
Protein: Subtilisin-like protease 3 (EC 3.4.21.62) (PfSUB3) (Q8I430)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Serine protease which may cleave PFN/profilin.
Subcellular location: Secreted {ECO:0000269|PubMed:22285468}.
Interaction partners:
Sequence:
MINRQYFIWYIFIFNIINKIYFENIRYVKNYEVVIRKKKNIERGIGNDFAFIRRYYKSRLLSDVSYKNNSIKGKNRVDKEGDIKKYDNNDDNKMDNSYDYKNKSIKENETKIRKEQVISLDKRYNRNINEKEEIKKKIKDIQRKRLIIYFKQDNTILSSRNYKHIFMKVLSSCGHIEKLTFINFYLYEFPKSINNEDMLLKICLRLLESRRINVENDNQISHTVQMKSYNNNNNKWDNINSKNNCIYQIKDKIKDLPNVSPSASTFTSISTSPYTLKLRDRNKYANDKNHIFKINHSNKHKNNNNNNNNNDYHNNNKSNYHSHSSAKCQTQRLNKKMIGTNILDGYDIIQMEEGLNLSHNYELNDVNVCIIDTGIDENHIDLKDNIIEKKTFMKHSYKKYNIDGINNIESDNIDGINNIESDNIDGINNIESDNIDGINNIESDNIDGINNIESDNIDGINNIKSSDNIKSSDNIKSSDNINSSDNIKSSDNNNVHTMLRNKLYLKKKKECSNYNTSNDGHGHGTFIAGIIAGNSPKGKKGIKGISKKAKLIICKALNNNNAGYISDILECFNFCAKKKARIINASFASTTHYPSLFQALKELQDKDILVISSSGNCSSNSKCKQAFQECNLNIQKLYPAAYSADLNNIISVSNIIQQSNGNIVLSPDSCYSPNYVHLAAPGGNIISTFPNNKYAISSGTSFSASVITGLASLVLSINSNLTSQQVIELFKKSIVQTKSLENKVKWGGFINVYDLVRFTIDSLPKDKDE
Protein: UDP-glycosyltransferase 73C12 (EC 2.4.1.368) (Oleanolate 3-O-glucosyltransferase UGT73C12) (K4GIP0)
Organism: Barbarea vulgaris (Yellow rocket) (Erysimum barbarea)
Function: Catalyzes the transfer of a glucose (Glc) moiety from UDP-Glc to the C-3 position of the oleanane sapogenins oleanolate and hederagenin, and to the C-28 carboxylic group of the lupane sapogenin betulinate. The monoglucosylated hederagenin 3-O-beta-D-glucoside is a feeding deterrent of the yellow-striped flea beetle (Phyllotreta nemorum).
Interaction partners:
Sequence:
MVSEITHKSYPLHFVLFPFMAQGHMIPMVDIARLLAQRGVKITIVTTPHNAARFKNVLSRAIESGLPISIVQVKLPSQEAGLPEGNETLDSLVSMELMIHFLKAVNMLEEPVQKLFEEMSPQPSCIISDFCLPYTSKIAKKFNIPKILFHGMCCFCLLCMHILRKNREIVENLKSDKEHFVVPYFPDRVEFTRPQVPVATYVPGDWHEITEDMVEADKTSYGVIVNTYQELEPAYANDYKEARSGKAWTIGPVSLCNKVGADKAERGNKADIDQDECLKWLNSKEEGSVLYVCLGSICNLPLSQLKELGLGLEESQRPFIWVIRGWEKNKELHEWFSESGFEERIKDRGLLIKGWAPQMLILSHHSVGGFLTHCGWNSTLEGLTAGLPLLTWPLFADQFCNEKLAVQVLKAGVSAGVDQPMKWGEEEKIGVLVDKEGVKKAVEELMGESDDAKEIRRRAKELGELAHKAVEEGGSSHSNITSLLEDIMQLAQSNN
Protein: Iron-sulfur cluster assembly protein 3 (AtISU3) (Protein ISCU-LIKE 3) (NifU-like N-terminal domain-containing protein ISU3) (NifU-like protein ISU3) (O81433)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:15792798}.
Interaction partners:
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Frataxin, mitochondrial
- Cysteine desulfurase, mitochondrial
- Molybdenum cofactor sulfurase
- Pyridoxal phosphate
- Molybdenum cofactor sulfurase-like protein
- Pyridoxal phosphate
- Pyridoxal phosphate
- Emb|CAB16785.1
- Heat shock 70 kDa protein 9, mitochondrial
Sequence:
MLRQTTKRAFLGLASQNPTPFPVVSRLYHPNVIDHYDNPRNVGSFDKNDPNVGTGLVGAPQCGDVMKLQVKFDGSGQIIDAKFKTFGCGSAIAASSVATEWVKGKSVEEVLTIKNSQIAKHLSLPPVKLHCSMLAEDAIKAAIKNYKEKQDKANGETVETIDSTYLHGIGS
Protein: Protein numb homolog (Q2LC84)
Organism: Rattus norvegicus (Rat)
Function: Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P49757}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49757}; Cytoplasmic side {ECO:0000250|UniProtKB:P49757}. Endosome membrane {ECO:0000250|UniProtKB:P49757}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49757}; Cytoplasmic side {ECO:0000250|UniProtKB:P49757}. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. {ECO:0000250|UniProtKB:P49757}.
Interaction partners:
- E3 ubiquitin-protein ligase
- 14-3-3 protein eta
- Dihydropyrimidinase-related protein 2
- E3 ubiquitin-protein ligase Mdm2
- Epidermal growth factor receptor pathway substrate 15
- E3 ubiquitin-protein ligase LNX
- AP-2 complex subunit alpha
- Neurogenic locus notch homolog protein 1
- Cadherin-1
- non-specific serine/threonine protein kinase
Sequence:
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVGPSVAPGNSAPSPSSPTSPTLDPTASLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQITSAFSTPCEDPFSSAPMTKPVTLVAPQSPVLQANGTDSALHVLTAKPASTALAPVAMPVRETNPWAHAPDAANKEIAAIHSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFVSTQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQATHPHQSPSLAKQQTFPQYETSSATTSPFFKPSAQHLNGSAAFNGVDNSGLVSGNRPAQVPPGTCPVDPFEAQWAALESKPKQRTNPSPTNPFSSDAQKAFEIEL
Protein: Nodulin-related protein 1 (AtNRP1) (RPS2-interacting protein 11) (Q9ZQ80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Prevents accumulation of abscisic acid (ABA) after heat treatment, thus reducing thermotolerance. May be a negative regulator of the ABA signaling/synthesis pathway. Required for defense responses against avirulent bacteria such as P.syringae pv. tomato DC3000 (avrRpt2) (Ref.5).
Interaction partners:
- Trigger factor-like protein TIG, Chloroplastic
- AT3g27090/MOJ10_18 domain protein)
- NAC domain containing protein 36
- DCD domain-containing protein NRP
- Nucleosome assembly protein 1;3
- Nucleosome assembly protein 1;1
- NAP1-related protein 2
- Nucleosome assembly protein 1;2
- Obg-like ATPase 1
- Putative NAC domain-containing protein 94
Sequence:
MDFFTDQVKKKFSDKKPESSDPEPNHNKNKPGHTEPTTHKPGHGEPTTHKPVSNTDPTTHRPATNAELMASAKIVAEAAQAAARHESDKLDKAKVAGATADILDAASRYGKLDEKSGVGQYLEKAEQYLHKYETSHSHSSTGGTGSHGNVGGHGGGAGAPAAKKEDEKSGGGHGFGDYAKMAQGFMK
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (Q6IQV5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Molybdenum cofactor biosynthesis protein 1
- Inosine triphosphate pyrophosphatase
- Alkaline phosphatase.
- Alkaline phosphatase
- GTP cyclohydrolase 1
- Alkaline phosphatase
- Alkaline phosphatase, intestinal, tandem duplicate 2
- 6-pyruvoyltetrahydropterin synthase.
- Nucleoside diphosphate kinase
- GTP cyclohydrolase 1 feedback regulatory protein
Sequence:
MEYQKAAELNSLCNGKIVTEYLCRNGFSDLTVDTKKVAVQHKNETSRKEEEDESRLPALEAAYTTILRGLGENTDRQGLLKTPLRAAKAMQFLTKGYHETIYDILNDAIFDEDHEELVIVKDIDMFSLCEHHLVPFFGKVHIGYLPSKKVVGLSKLARIVEIYSRRLQVQERLTKQIAMAISEALQPVGVAVVIEAAHMCMVMRGVQKMNSRTVTSAMLGVFREDPKAREEFLALAKSAQ
Protein: histidine kinase (EC 2.7.13.3) (H7C7G9)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Polar differentiation response regulator
- histidine kinase
- Histidine phosphotransferase ChpT C-terminal domain-containing protein
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
Sequence:
MADLQLQDKVSTGAPRRRFDPWLVGAAVFFVAAAALSAAPALKAGPTTLAGLLLLLGVAGVAVLGLVAIRGSALSGGDADQAEGFIEALAEPAALAAADGRVLAANGPWREVMGEQRRLPKGVAGSSLFAALVQARQGQMAEGMLSAGGTDYTAKVSRLAGGRLMIRLAPIVVAEPVVEDASPAPVAERAAPPPSSLDAFAGASPFGAALLEGLEPFTSRVLETNPALTTMTGAKAGVLFGDLIDAASRAEAETRLNEGRAGPYEVRLARDPSRIAHLYLYRAEGRLVAYMIDVSEQKQIELQLSQAQKMQAIGQLAGGVAHDFNNLLTAIQLRLDELLHRHPVGDPSYEGLNEIRQTGVRAADLVRKLLAFSRKQTVQREVLDLGELISEFEVLLRRLLREDVKLITDYGRDLPQVRADKSQLETAVMNLAVNARDAVRAAKGGGVVRIRTARLTRDEAIQLGFPAADGDTAFIEVSDDGPGIPPDVMGKIFDPFFTTKPVGEGTGLGLATVYGIVKQSDGWIHVHSRPNEGAAFRIFLPVYEAPAGAVAVQAVAEPAKPRAARDLSGAGRILFVEDEDAVRSVAARLLRARGYEVLEAADGEEALIIAEENAGTIDLLISDVIMPGIDGPTLLKKARGYLGTAPVMFISGYAEAEFSDLLEGETGVTFLPKPIDIKTLAERVKQQLQAA
Protein: Heat shock protein family B (small) member 7 (C9J5A3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MFSDDFGSFMRPHSEPLAFPAAHPTARPGGAGNIKTLGDAYEFAVDVRDFSPEDIIVTTSNNHIELAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQQTFRTEIKI
Protein: Evasin P991 (A0A023FFD0)
Organism: Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)
Function: Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL2, CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL6, CCL7, CCL8, CCL9, CCL11, CCL12, CCL13, CCL14, CCL16, CCL17, CCL18, CCL19, CCL22, CCL23, CCL24 and CCL27.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MHSTIVYACLLALAVFVALHGTPLAALAENGEGTTQPDYDNSTDYYNYEDFKCTCPAPHLNNTNGTVMKPIGCYYTCNVTRCTAPDTYPCYNLTEHQAKNLTTSPTTLCAVGNCDHGICVPNGTKELCFKAPNLEE
Protein: SUMO1 activating enzyme subunit 1 (M0R286)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYH
Protein: Dck1p (A0A1D8PH11)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Lmo1p
- Rho family GTPase
- Cell division control protein 42 homolog
- Uncharacterized protein
Sequence:
MTWIRTDFLIKGKIIKPFLPNDKHPNLKNKNFKNLYPGDQVFIFEVKDTKWARVHAVTKPLPTDYIACTAFLHDLLVDKSNVVVVPLSYIKILKEMPSEDIRISKKFNNIHENSEIPTIRDTELARQEAVDGTILNEFIKKSVPPRPTKRDHSRDTLLDEIKYSLELLNAHIFAVYSKSEFRLFEKLTSIYYSLYEIRTKLNHHLLTSEEAQVARETATFLLNRIPKILASRASRLGKDVIELDYSDTDVSGYKSILSRDAETGEVLSLKTALPPRIALNNELGALVPNYPINIHDNFHNYSLKPSANKKFYHDPPSHILVDFKSVTGSSAYQPPGFAGMVAYMYIRNSKKRLTEAFAVHTNSVEDFVHVEKISAALFRNLPASEIENNRVYLVAVLTEEVDLNIKGTGHTPTIKRVKKGVAAGVADITRIFPRAEGSLQSGEAHNFSIKLFGSYLSKKGHKNMVEDLRGLSNNGWGELVDRIIAGSSQGVAVNPRAEKLVITVKEFKHQFQGNVANQLSSSAPISRIKPIFFDPLAENYERIYLKMGKVTLLGSNAREDLLTFEVSTPNNELITFAKASNQQEKRYWQFISVFPGESIGEIVKVNGVALKNSSKKLPKDDYILLSLYVNGVLAGEGRLLYKSGNRLVEFNKKKTHTIEIISATHNVPMAHIELSTEYVGKVYNSDVSIDNIFQYERFFQNGQKGIDELSNSLVAFTRLDIAQVVKYFPELLSSLYGIIGFSSHHSGPSIEILEDNTFKAVIHLLDTVFGKQDQYLYLLDNFIAKYKSSNQIGIFLLTKVEQIFNRAGSSWNSVSRSVCRVLSIILRISILSMNAPNEQDLYLQTLNNLFKSIAYLLTLDSTNMIDDQVLVMDIIDYIFAFDVNFKGSELVQIMINCIDSIGLKGVGVDELSMESTPAGSRSIKDHKIIIGKLLLILRLLNSDLVKEESSRCILIPKAITWAVDVFLAPTDIEATRLACSVLNAACTALWNDGVIGKYQGDMEICYSLAKFLPAISRTFIKYNKFTRGNGSFKKKRVFTQLFPSTYPFIEFSIDPVVNDESMVEVLVELAITFSFVARVGKEAAGNEGYITILDSRIENDFFIPEKYLASDFHGEDILTLLSGIRYMRLGKYFPETKWYSTYSVIIEGCLCAIELVRPLVIINQLPALDDSESFDRTLWGNYLRSLFKLAVLPPVAVEHLSDVPKSACAKITNDVRKRAAFLINEAWDSLAWDATDEDMLRFNLKKFGGYQVEFINDEFGILPDLMLLGLQRDSECQSVAIKILWSIMISEYILSDTLQDVERQCLLGLHEIYHNNSYKPTSLDQENFIERMKMTVRLDREDEAFDIIYNFIQNLSSFFGTLNYYISVPFGPEYEEDRIFHEIKLKAQIKNAGKPELFNSYIHQMYEKYLSQNDYVQAALSLELLASTYSWDHHIIVPASFRPKFPEQSSFERKEILLKMIANNFVKGNSLEKAADTYNELLDSYNEHTYDLKSFAYVHNKLAQLYLDMESSDKLTPTYFKVEAIGGGFPTYLTQISQIFQGLPFEHITSIHERFLKVFPGAKIISDDAEAIRLKEKATNGRYLYIKTVEPVYEFSDKLINTSLGVRQYARNKDLRFFTSLKKFPGATSVFDLWTEETTYETWLSFPTLMNRSFIKDSKTVKLSPLDNAVRTIAAKNDDLIQLEAFINAALKEKTDYSHYFNDLSRQLAGTVDSPVNGGVGQYRAFFSDSKYQINEESIAKTELLRNAFNDLAIILYRCLNLHGSLIGLSMKSSHQALVELFRKNFQEEIVALRLGEEATITAPSSSRVSIFHNKRANGLMTERANSISNMSGAGSTYSGSRLARSPTNASSVSSNNSSITRSGRASNTSGYPASVIQPGYTGLKGSSLKNGNGSVTSKSINGSGKTNAINTKW
Protein: Uncharacterized protein C119.16c (O42907)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSIQAIVLATFDAKEGYNVENYYPGDFNVEGIEYLLFPSGIQELDNCTIFFRFQDQLCLSVFSKLQHPSFERSAFFTSVGLILSDDINFGEAVVKYGETLLYIANGLSLATLKYKFGEDASETYASEKCTSHQLSDSDFFKSLQTSAVNLEFDSLFEKLQGNKFAILGANSKELSQSYATILLDHLGPAFYCLYKFALQRKRILLISSHDDQLYSIIDMIVRLSSIKRSSDASIPILLSDLHPFYSVGLANTSTLLDNDLEEGWIACTTDTVLLSKSSLYDLALYWPDNSFNANKYPQIFNSNSIRIKPSYDDLINFKGLSRYLSFDGESSWGLTTYSLASKYIFNTSHHNLTDQEFLNENMLDYFQRYNQKLLTVLSSNAESFNVSDMQTLGLNPCHSLDKSFVSEISQIWLKKHINWQYGKYFWLRRVSLIFLASTCFLFILWKLL
Protein: Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) (Q14393)
Organism: Homo sapiens (Human)
Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Subcellular location: Secreted {ECO:0000269|PubMed:9326369}.
Interaction partners:
- Tyrosine-protein kinase receptor UFO
- Tyrosine-protein kinase Mer
- Tyrosine-protein kinase receptor TYRO3
- Lactadherin
- High affinity nerve growth factor receptor
- Vitamin K-dependent gamma-carboxylase
- Vitamin K-dependent protein S
- Tubby-related protein 1
- T-cell immunoglobulin and mucin domain-containing protein 4
- Furin
Sequence:
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q7KTU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
Sequence:
MKNHNKYVKLPQDLDLSFHSDLDLLPDTAADIDVELDPAADTDVAALSVNVPASLGLDEDDDDEVIIAPGGGGLRLAPTAAEAVAAHRQHHQQHQQCKQLKNQLEQKQILPKSKICGLGSDSIVETGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFERTMERKMYSTRSELDFV