wanglab/gogpt-training-data huggingface dataset:
Protein: Mitogen-activated protein kinase 5 (MAP kinase 5) (EC 2.7.11.24) (Benzothiadiazole-induced MAP kinase 1) (MAP kinase 2) (Multiple stress-responsive MAP kinase 2) (OsBIMK1) (OsMAP1) (OsMAPK2) (OsMAPK5) (OsMPK3) (OsMSRMK2) (Q10N20)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in disease resistance and abiotic stress tolerance signaling pathways. Acts as a positive regulator of drought, salt and cold tolerance. Negatively modulates pathogenesis-related (PR) gene expression and broad-spectrum disease resistance. Functions downstream of CPK18 in a signaling pathway that represses defense gene expression and negatively regulates resistance to rice blast fungus. Phosphorylated by CPK18 at Thr-14 and Thr-32 and activated independently of MAP kinase kinase (MKK) phosphorylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:25035404}. Cytoplasm {ECO:0000269|PubMed:25035404}.
Interaction partners:
- mitogen-activated protein kinase kinase
- protein-serine/threonine phosphatase
- Nucleoside diphosphate kinase
- Os11g0160500 protein
- 1-aminocyclopropane-1-carboxylate synthase 2
- Mitogen-activated protein kinase 1
- Nucleoside diphosphate kinase 1
- Os08g0508700 protein
- Os09g0490200 protein
- mitogen-activated protein kinase kinase
Sequence:
MDGAPVAEFRPTMTHGGRYLLYDIFGNKFEVTNKYQPPIMPIGRGAYGIVCSVMNFETREMVAIKKIANAFNNDMDAKRTLREIKLLRHLDHENIIGIRDVIPPPIPQAFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQILRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRQPLFPGRDHMHQMRLITEVIGTPTDDELGFIRNEDARKYMRHLPQYPRRTFASMFPRVQPAALDLIERMLTFNPLQRITVEEALDHPYLERLHDIADEPICLEPFSFDFEQKALNEDQMKQLIFNEAIEMNPNIRY
Protein: Probable ribosomal protein (Ribosomal protein L19e family protein) (Q680Q9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS2y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL3y
- Small ribosomal subunit protein uS2z
- Large ribosomal subunit protein eL42z/eL42y
- At1g43860
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL3z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL24z
Sequence:
MVSIHFHSRSRARRKCRHTGYGKDTMEALRRIMKRLTRRLKMLKRLLKKFCWNKKIDKLVYYHDMFMKVKGKVYKNKCVLMESMHKSSRERKFSGSEMRLALEPEGEKTASAPQ
Protein: Gonadotropin-releasing hormone receptor (O77152)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAKVAEENDHRDLSNWSNVNDTNGTIHLTKDMVFNDGHRLSITVYSILFVISTIGNSTVLYLLTKRRLRGPLRIDIMLMHLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYFAILKPLKRSYNRGRIMLACAWLGSVVCSIPQAFLFHLEEHPAVTGYFQCVIFSSFRSDFDEKLYQAASMCSMYAFPLIMFIYCYGAIYLEIYRKSQRVLKDVIAERFRRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTISMWYWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYGLYNIRGRMNNNNPSVNNRHTSLSNRLDSSNQLMQKQLTNNSLLNGRGQVMAAAVSATTKLANVVSLKGNANGNGSAAAAGTVPITPPLTVTIAPLATDDEANDDSCLSAVTIRCQDQSPIRQK
Protein: RE37203p (Q86LF3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYERWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTMIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYPPTTEYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSPSSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASPPVEEKRLLQPLSSTPVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTTTHTTTATLSSQPAAQPRRTHLVEGVPQTSV
Protein: Nucleolin (Protein C23) (P13383)
Organism: Rattus norvegicus (Rat)
Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P19338}. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Nucleophosmin
- rRNA 2'-O-methyltransferase fibrillarin
- Heterogeneous nuclear ribonucleoprotein U
- Eukaryotic translation initiation factor 3 subunit A
- Heterogeneous nuclear ribonucleoprotein K
- Calreticulin
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Calreticulin
- Receptor protein-tyrosine kinase
Sequence:
MVKLAKAGKTHGESKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAAATPAKKAVTPAKVVPTPGKKGAAQAKALVPTPGKKGAVTPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDEEDEFEPPVVKGVKPAKAAPAAPASEDEDEEDDDDEDDDDDDEEEEEEDDSEEEVMEITPAKGKKTPAKVVPVKAKSVAEEEEDDEDDEDEEEDEDEEDEEDDEDEDEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKIEGSEPTTPFNLFIGNLNPNKSVAELKVAISELFAKNDLAAVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAVEIRLVSQDGRSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNPHGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE
Protein: Albumin (Alpha-livetin) (allergen Gal d 5) (P19121)
Organism: Gallus gallus (Chicken)
Function: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
Subcellular location: Secreted.
Interaction partners:
- Actin, cytoplasmic 1
- Peroxidasin.
- Uncharacterized protein.
- Ovalbumin
- Insulin
- Collagen alpha-1
- Glyceraldehyde-3-phosphate dehydrogenase
- Myoglobin
- Alpha 2-HS glycoprotein.
- Transthyretin
Sequence:
MKWVTLISFIFLFSSATSRNLQRFARDAEHKSEIAHRYNDLKEETFKAVAMITFAQYLQRCSYEGLSKLVKDVVDLAQKCVANEDAPECSKPLPSIILDEICQVEKLRDSYGAMADCCSKADPERNECFLSFKVSQPDFVQPYQRPASDVICQEYQDNRVSFLGHFIYSVARRHPFLYAPAILSFAVDFEHALQSCCKESDVGACLDTKEIVMREKAKGVSVKQQYFCGILKQFGDRVFQARQLIYLSQKYPKAPFSEVSKFVHDSIGVHKECCEGDMVECMDDMARMMSNLCSQQDVFSGKIKDCCEKPIVERSQCIMEAEFDEKPADLPSLVEKYIEDKEVCKSFEAGHDAFMAEFVYEYSRRHPEFSIQLIMRIAKGYESLLEKCCKTDNPAECYANAQEQLNQHIKETQDVVKTNCDLLHDHGEADFLKSILIRYTKKMPQVPTDLLLETGKKMTTIGTKCCQLGEDRRMACSEGYLSIVIHDTCRKQETTPINDNVSQCCSQLYANRRPCFTAMGVDTKYVPPPFNPDMFSFDEKLCSAPAEEREVGQMKLLINLIKRKPQMTEEQIKTIADGFTAMVDKCCKQSDINTCFGEEGANLIVQSRATLGIGA
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (F5H232)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIQAFEGVLR
Protein: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) (P0A7D7)
Organism: Escherichia coli (strain K12)
Function: Converts 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) to 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide (SAICAR).
Interaction partners:
- Adenylosuccinate lyase
- N5-carboxyaminoimidazole ribonucleotide mutase
- Phosphoribosylformylglycinamidine cyclo-ligase
- Phosphoribosylformylglycinamidine synthase
- N5-carboxyaminoimidazole ribonucleotide synthase
- Bifunctional purine biosynthesis protein PurH
- Phosphoribosylamine--glycine ligase
- Phosphoribosylglycinamide formyltransferase
- Amidophosphoribosyltransferase
- Outer membrane protein assembly factor BamC
Sequence:
MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
Protein: WD_REPEATS_REGION domain-containing protein (D1MN68)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSLSLSPDFRTFISGACDASAKLWDIRDGMCKQTFPGHESDINAVAFFPSGNAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLFAGYDDFNCNVWDSMRQERAGVLAGHDNRVSCLGVTEDGMAVCTGSWDSFLKIWN
Protein: RNA-binding protein 48 (Q5RL73)
Organism: Homo sapiens (Human)
Interaction partners:
- Armadillo repeat-containing protein 7
- U5 small nuclear ribonucleoprotein 40 kDa protein
- Pre-mRNA-processing-splicing factor 8
- Sodium channel modifier 1
- Cysteine-rich PDZ-binding protein
- RING-type E3 ubiquitin-protein ligase PPIL2
- Spliceosome-associated protein CWC27 homolog
- E3 ubiquitin-protein ligase RNF113A
- Smad nuclear-interacting protein 1
- 116 kDa U5 small nuclear ribonucleoprotein component
Sequence:
MASSGGELGSLFDHHVQRAVCDTRAKYREGRRPRAVKVYTINLESQYLLIQGVPAVGVMKELVERFALYGAIEQYNALDEYPAEDFTEVYLIKFMNLQSARTAKRKMDEQSFFGGLLHVCYAPEFETVEETRKKLQMRKAYVVKTTENKDHYVTKKKLVTEHKDTEDFRQDFHSEMSGFCKAALNTSAGNSNPYLPYSCELPLCYFSSKCMCSSGGPVDRAPDSSKDGRNHHKTMGHYNHNDSLRKTQINSLKNSVACPGAQKAITSSEAVDRFMPRTTQLQERKRRREDDRKLGTFLQTNPTGNEIMIGPLLPDISKVDMHDDSLNTTANLIRHKLKEVISSVPKPPEDKPEDVHTSHPLKQRRRI
Protein: Biogenesis of lysosomal organelles complex-1, subunit 2 (Biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1) (A2BIA5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- SNARE-associated protein Snapin
- Dystrobrevin-binding protein 1b.
- Deoxyribose-phosphate aldolase
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Dysbindin-A
- BLOC-1-related complex subunit 7
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- BLOC-1 related complex subunit 6
- BLOC-1-related complex subunit 8
Sequence:
MAATGDEAAAMDSISKAPAPPTELNLTAEPENSREATTSDTTENQKPKRPSNNNDGGVETAEEATEPAEPDINELCRDMFDKMSVFLQGELTATCEDYKLLENMNKLTSLKYMEMKDISINISRNLQDLNQKYASLQPYLDQINQIEEQVTALEQAAYKLDTYSKKLEAKFKKLEKR
Protein: Heparanase (EC 3.2.1.166) (Q90YK5)
Organism: Gallus gallus (Chicken)
Function: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety (By similarity). Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:11387326}. Note=Localized close to cell surface.
Interaction partners:
- Heparanase 2
- Sulfatase domain-containing protein.
Sequence:
MLVLLLLVLLLAVPPRRTAELQLGLREPIGAVSPAFLSLTLDASLARDPRFVALLRHPKLHTLASGLSPGFLRFGGTSTDFLIFNPNKDSTWEEKVLSEFQAKDVCEAWPSFAVVPKLLLTQWPLQEKLLLAEHSWKKHKNTTITRSTLDILHTFASSSGFRLVFGLNALLRRAGLQWDSSNAKQLLGYCAQRSYNISWELGNEPNSFRKKSGICIDGFQLGRDFVHLRQLLSQHPLYRHAELYGLDVGQPRKHTQHLLRSFMKSGGKAIDSVTWHHYYVNGRSATREDFLSPEVLDSFATAIHDVLGIVEATVPGKKVWLGETGSAYGGGAPQLSNTYVAGFMWLDKLGLAARRGIDVVMRQVSFGAGSYHLVDAGFKPLPDYWLSLLYKRLVGTRVLQASVEQADARRPRVYLHCTNPRHPKYREGDVTLFALNLSNVTQSLQLPKQLWSKSVDQYLLLPHGKDSILSREVQLNGRLLQMVDDETLPALHEMALAPGSTLGLPAFSYGFYVIRNAKAIACI
Protein: Acyl-coenzyme A thioesterase 10, mitochondrial (Acyl-CoA thioesterase 10) (EC 3.1.2.-) (Mitochondrial 48 kDa acyl-CoA thioester hydrolase 2) (Mt-ACT48.2) (Q32MW3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Active on long chain acyl-CoAs.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10383425, ECO:0000305}.
Interaction partners:
Sequence:
MKRAAMRLWTLNKGLLTHGRGLSQGSQYKISEPLHIHQVQVKLREIVGISTVWRDHVQAMEERKLLHSFLPKSQKVLPPRKIRDSYIEVLLPLGTDPELRDKYVTVQNTVRFGRILEDLDSLGVLVCYMHNHNHSTNMSLLSIVTVLVDKIDMCKHSLSPEQDIKFTGHVSWVGNTTMEVKMKMFQLHDDETYWPVLDATFVMVAQDSENKRPAFVNPLIPENKEEEELFTQGELNKSRRIAFSTSSLLKVAPSSEERNIIHELFLSTLDPKTISFQSRILPPKAVWMEDTKLKSLDICHPQERNVFNRIFGGFLMRKAYELAWATACSFGGSRPYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQGNYIQVRVHSEVFSLDSREHMTTNVFHFTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVTLKKDYPVEP
Protein: Protein SUPPRESSOR OF NIM1 1 (Q8LL17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates negatively a plant defense signaling pathway which is independent of salicylic acid (SA) and systemic acquired resistance (SAR). Confers sensitivity to P.syringae and P.parasitica.
Interaction partners:
- Protein RALF-like 3
- Defensin-like protein 246
- Defensin-like protein 8
- Receptor-like protein 55
- F-box protein CPR1
- F-box protein DOR
- Zinc finger MYM-type-like protein
- Zinc finger MYM-type-like protein
- Kinesin-like protein
- Protein REDUCED CHLOROPLAST COVERAGE 3
Sequence:
MALPWELEEDILSRLPPISLVRFRTVSKHWNSLFNDKTFINNHLSRSRPEFIILTNSKIYSVDIIDHNNIDPTIRLHEIPTYDIHSRGTDLNRTIINTCDEFLFYNYRYWDNMTALWNPWLRQVRWIEYANQEFCVFGLGYDNSRPEKVYKILGHLFCHGKVLRDQKVVIYECASDSLRFIDRPEDDDWPITETAKRSNVSLNGNLYWFGCSNYENDEYYIRIFDFSTEDFKPFCLLPCQMSHSTDELVLAVYKGDRFSLLKQCSVTREIGVWVTKERISNDNGNGGEGVEWLKLMTLSKPNLPKLFGTVSYFIYGKTLYMCNGDDETALACIYIVREDVCKKFQIGSGNINCRHCVYTPNLLSLPLFIG
Protein: Protein BEX1 (Brain-expressed X-linked protein 1) (Q9HBH7)
Organism: Homo sapiens (Human)
Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q3MKQ2}. Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ2}. Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. {ECO:0000250|UniProtKB:Q3MKQ2}.
Interaction partners:
- Rhombotin-2
- LIM domain-binding protein 2
- LIM domain-binding protein 1
- Helix-loop-helix protein 2
- Calmodulin-like protein 4
- Calmodulin-like protein 5
- Calmodulin-like protein 6
- Calmodulin-like protein 3
- Olfactory marker protein
Sequence:
MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP
Protein: Dual specificity phosphatase 10 (D3ZBG7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Mitogen-activated protein kinase 14
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
Sequence:
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSASPGSNNHTPVIATAVVTLKAANLTYMPSSSGSARSLNCGCSSTSCCTVATYDKDHQAQTQAIAAGTATTAIGTSTTCPANQMVNNNENIGSLSPSGGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVTPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHGNLCDNSLQLQECREVGGGASAASSVLPQSVPSTPDIESAELTPILPFLFLGNEQDAQDLDAMQRLNVGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGMETVV
Protein: Coilin (A1Z7A8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Required for Cajal body formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19158395}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19158395}. Nucleus, Cajal body {ECO:0000269|PubMed:19158395, ECO:0000269|PubMed:23885126}. Chromosome, centromere {ECO:0000269|PubMed:19158395}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19158395}. Note=Detected in the CBs of cells from a number of different larval and adult tissues. In stage 8-9 oocytes detected only in the single CB of the germinal vesicle. Also detected in the histone locus bodies (HLBs) of late stage nurse cells, and low expression in the HLBs of large polytene or polyploid nuclei within the salivary glands, fat bodies and Malpighian tubule cells. In germline stem cells and cystocytes (where CBs are not evident), expressed throughout the nucleoplasm. During interphase localized to foci scattered throughout the nucleoplasm. During metaphase (in meiotic and mitotic cells) these foci localize to the centromere regions on the metaphase plate. At anaphase, no longer detected as foci and is instead detected throughout the spindle. When the nucleus reforms, it localizes to multiple nuclear foci and throughout the nucleoplasm. {ECO:0000269|PubMed:19158395}.; SUBCELLULAR LOCATION: [Isoform C]: Cytoplasm {ECO:0000269|PubMed:19158395}. Note=Very low expression and not detected at the protein level. Relatively higher levels of expression in the cytoplasm of follicle cells that have no expression of Isoform D in their CBs. {ECO:0000269|PubMed:19158395}.
Interaction partners:
- Multi sex combs, isoform A
- rRNA 2'-O-methyltransferase fibrillarin
Sequence:
MQHSSMKVDLSNFFKDERRNSLVFIDAAWNNIKDLQDHIQNLFSLKDISLLTSDGCYLPPRESIKVLNSAEGLKAFRFASHDSDTFVSPAPVKSSKKRKNRSVEEQVHLTASTPLRPSKRSKNQNNSEWINIAENPSRVRKKELLDMAPGPSVQSKLLTNKGTPKAPETQTEVSNMSANIETENKESAPQIKNKSKNKKPTKSPEASDQVENEPAPKSISRCTLKEGKMSESKNQETSPDILSEKSGVVTKENETREEQQDKTHLESNKIPDKLSQLKAGDQIEKSPGIAASLLSISFRSPLLEMPFNVPRIFQFPTKKQQIEILEYKKLKPISPRFLLQKGAKSDDTAKQFPSNGKDSTLKPKSYEILHDEELPDVKDKKNVSEGIKRAVAPLCEDIIETSTTLPGAIGAVESAYLDNSTEAETTLPSEAEATNPLELTESFLQNNTSMEKTPKVEKILPDDGSASPIKNNVDSKDVKTVTVPIFEEQLVSDSDDDVMLVDDSNIDVSYGDSDIEPIPVVENRQSLDIIRDLLRTATPLNSLPSRGDTVIFKLLKIKGNANSGTTEFVAGRCTYVNRRTKIVTVETITYPPEIGRMLRQYYMSGLDESSEDVRTLSIHLKDMLEAKIIVATID
Protein: Probable methyltransferase PMT4 (EC 2.1.1.-) (Q8GYW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Hydroxyproline-rich glycoprotein family protein
- Protein MANNAN SYNTHESIS-RELATED 1
- At5g55620
- At2g16630
- Mitotic checkpoint protein BUB3.2
- Outer arm dynein light chain 1 protein
- Beta-galactosidase 5
- Probable arabinosyltransferase ARAD2
- Cytochrome P450 76C1
- Pectinesterase 31
Sequence:
MKVASVIGLRPRISGLLFLTLGVIALITILVPNSDSSSTTSTTRVPPSNIYSNYGRVKEQAAVDYLDLRFFSLGVNRLKEFPLCGKERDNYVPCYNVTESDRNCEFAREEERCLVRPPRDYKIPLRWPVGRDIIWTGNVKITKDQFLSSGTMTKRLMLLEENQITFHSDDGLIFDGVKDYAFQIAEMIGLGSDTEFPQAGIRTVLDIGCGFGSFGAHLVSLNVMPICIAEYETSGSQVQLALERGLPAMIGNFFSKQLPYPALSFDMVHCAQCGITWDIKDAMLLLEVDRVLKPGGYFVLTSPTSKAQGNSPDTKKTSISTRVDELSKKICWSLSGQQDETFLWQKTADPNCYSSRSQASIPVCKDDDSVPYYHPLVPCISGTKSKRWIPIQNRSRASGTSLSELEIHGIKPEEFDEDIQVWRSALKNYWSLLTPLIFSDHPKRPGDEDPVPPFYMIRNAMDMNARYGNLNQALLNQGKSVWVMNVVPVKARNTLPIILDRGFTGALHDWCEPFPTYPRTYDMLHANELLTHLSSERCSLMDLFLEMDRILRPEGWVVLSDKLGVIEMARTLAARVRWEARVIDIQDGSDQRLLVCQKPLLKK
Protein: Lim and transglutaminase domain protein ltd-1 (Kyphoscoliosis inactive peptidase homolog ltd-1) (G5EF51)
Organism: Caenorhabditis elegans
Function: Cytoskeleton-associated protein (Probable). May play a role in hypodermal cell development (Probable).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12204272}.
Interaction partners:
- FCH domain only protein 2
- Calponin-homology
- Homeobox domain-containing protein
- Chitin synthase chs-2
- 26S proteasome non-ATPase regulatory subunit 10
Sequence:
MNSKQHCNRCGKQVYPTDKVGPLKDSTFFHQGCFKCYICGTRLALKTYCNNRNDINDKEVYCSNHVPIAGPHDLPMASTNGSGKNLENNNHVKNGNWIDAGLSDMKIAHAMKATQVARPYPKISHEGAKYVVDYDTQTRLELLHRKDEDDLYESFQDKRVREAEEFEKENTEEWEKALAEFAKKYEKGQSNMKKDDLIRQLTIKREKKLETLHTKRKERERHQTAELVDRQAKEMLELFKASRSEYSNLQYPSTPPPPVPPSCSKREIYTTTDYFSSIDEVAIHCARNEVASFTDLIRTLSSGARSDVDVARAIYRWITIKNLNTMIFDDSIQNDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGFSKSAGYQPGYSFDDHRFRNTWNAVFLDGSWRFVQCNWGARHLVNAKDGSHEAKTDGNLRYEYDDHYFMTDSEEFIYEFFPSDHAWQLLPRPLSLLQFERIPFVRSLFFKYNLSFIDNKLESTVYTDKSGAASISIRLPPKGDSLIFHYNLKFFDSEENTISGMSLKRFVMQSVTEDVVTFRVHAPSTRPLLLDIFANSVSSGAYLTGQPIKFKSVCKFKVVCESLQVIMVPLPECASGEWGPAKATRLFGLLPISHPDAIINTGRYVEIRFRMTRPLSEFVASLHRNRTDDRALQACTRSALKGDMVYIQIEFPGEGQYGLDIYTRQDDQLINGKQLLTHCCKYLIHSRNC
Protein: Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) (Q91WV0)
Organism: Mus musculus (Mouse)
Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Dr1-associated corepressor
- YEATS domain-containing protein 2
- Cysteine-rich protein 2-binding protein
- DNA polymerase epsilon subunit 3
- TATA-box-binding protein
- Transcriptional adapter 2-alpha
- MAP3K12-binding inhibitory protein 1
- WD repeat-containing protein 5
- SAGA-associated factor 29
- ZZ-type zinc finger-containing protein 3
Sequence:
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASTQAGSSQDEEDDDDI
Protein: V-type proton ATPase subunit e 2 (V-ATPase subunit e 2) (Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2) (Vacuolar proton pump subunit e 2) (Q8NHE4)
Organism: Homo sapiens (Human)
Function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q5EB76}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5EB76}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit H
- V-type proton ATPase subunit F
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit D
- V-type proton ATPase subunit G 2
- V-type proton ATPase subunit d 2
- V-type proton ATPase subunit E 1
Sequence:
MTAHSFALPVIIFTTFWGLVGIAGPWFVPKGPNRGVIITMLVATAVCCYLFWLIAILAQLNPLFGPQLKNETIWYVRFLWE
Protein: Chemokine K203 (Q4KS30)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Chemokine receptor
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Interferon regulatory factor 5
- C-C motif chemokine 4 homolog
- C-C motif chemokine
- C-X-C motif chemokine ligand 13
- C-C chemokine receptor 7
- Interleukin-6
- C-X-C motif chemokine receptor 4
- SCY domain-containing protein
Sequence:
MKLSAVVLVLLIASFCSRASSAPVGPDVPTCCTTYITHKIPRNLIQRHYSTSTSCSKPAIIFITKKEREVCANPSDPWVQRYLQSVKRD
Protein: Na,K-ATPase alpha subunit isoform 1a (Q5IRA2)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHDADTTENQSGTSFDKSSATWAALARVAGLCNRAVFLAEQNNVPILKRDVSGDASETALLKCIELCCGSVKDMREKYSKVVEIPFNSTNKYQLSIHENNTAGESNHLLVMKGAPERILDSCSTILLQGKEHPLDDEIKESFQKAYEALGGLGERVLGFCHFQLPDDQFPEGFDFDCEDVNFPTENLCFVGLM