wanglab/gogpt-training-data huggingface dataset:
Protein: SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (Q8R2Y9)
Organism: Mus musculus (Mouse)
Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment (By similarity). {ECO:0000250|UniProtKB:Q9BQ15}.
Interaction partners:
- Integrator complex subunit 3
- SOSS complex subunit C
- Integrator complex subunit 6
- Integrator complex subunit 5
- Integrator complex subunit 1
- SOSS complex subunit B2
- Integrator complex subunit 11
- Integrator complex subunit 9
Sequence:
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYNTQQAPNKSVQNNDNSPTAPQATTGPPAASPASENQNGNGLSTQLGPVGGPHPSHTPSHPPSTRITRSQPNHTPSGPPGPSSNPVSNGKETRRSSKR
Protein: F-box domain-containing protein (O17054)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTDKKENTLGGCLQETAEITNMMTSVKFPREEPTFSNMPIEILTEVVNKLEPINRLVLQKVSRKLREFVNNMNPGIAFLRIDFTADWARLMVDKYEIICSKTGKSCQLKLLDEEKHELRKKTIEKYYYSDIILNDWRAIITKPKLRLNELYICLLSGGRTRLNSLQDIENILQTMKPLPVKHIHLLGYLFSELPVVFQHFQPGVLENIRLHSYQVTDDLTDLVTTSEQWNKAKSLEITGYCTLPKEMENLFHFEHFQLLLTQFSKTDASNVKKALRKPSKFVSGTFEIFIYNPAEVASVFDPQYTGGINGSIDYNVLEANSMFRLIFSQKRMIIEKMS
Protein: Inosine-uridine preferring nucleoside hydrolase (IU-NH) (IU-nucleoside hydrolase) (EC 3.2.2.2) (EC 3.2.2.3) (Non-specific nucleoside hydrolase) (P83851)
Organism: Leishmania major
Function: Catalyzes the hydrolysis of the N-glycosidic bond of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates. Likely functions in purine salvage from the host, a fundamental pathway since protozoan parasites such as L.major are incapable of de novo purine biosynthesis.
Interaction partners:
Sequence:
MPRKIILDCDPGIDDAVAIFLAHGNPEIELLAITTVVGNQSLEKVTQNARLVADVAGIVGVPVAAGCTKPLVRGVRNASHIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEPRIVDRVKEVVLMGGGYHTGNASPVAEFNVFIDPEAAHIVFNESWNVTMVGLDLTHQALATPAVQKRVREVGTKPAAFMLQILDFYTKVYEKEHDTYGKVHDPCAVAYVIDPTVMTTERVPVDIELNGALTTGMTVVDFRYPRPKNCRTQVAVKLDFDKFWCLVIDALERIGDPQ
Protein: Guanine nucleotide-binding protein subunit gamma (G3V8K2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU004973}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU004973}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU004973}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Protein kinase C epsilon type
- 5-hydroxytryptamine receptor 7
- Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Sequence:
MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPTSENPFREKKFFCALL
Protein: Ethylene-responsive transcription factor ERF025 (Q9FJ90)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Putative UPF0481 protein At3g02645
- Ethylene-responsive transcription factor ERF120
- Protein SMALL AUXIN UP-REGULATED RNA 54
Sequence:
MSNNNNSPTTVNQETTTSREVSITLPTDQSPQTSPGSSSSPSPRPSGGSPARRTATGLSGKHSIFRGIRLRNGKWVSEIREPRKTTRIWLGTYPVPEMAAAAYDVAALALKGPDAVLNFPGLALTYVAPVSNSAADIRAAASRAAEMKQPDQGGDEKVLEPVQPGKEEELEEVSCNSCSLEFMDEEAMLNMPTLLTEMAEGMLMSPPRMMIHPTMEDDSPENHEGDNLWSYK
Protein: Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt) (Q5XF75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Interaction partners:
- Elongation factor Tu, chloroplastic
- Elongation factor Tu
- Ribosome-recycling factor, chloroplastic
- Ribosome-recycling factor, chloroplastic
- Trigger factor-like protein TIG, Chloroplastic
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Translation initiation factor IF3-1, mitochondrial
- Small ribosomal subunit protein bS1c
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- ATP synthase subunit b, chloroplastic
Sequence:
MAFARAVRRPIGVFYYSVSSRFSSGNEYSTVASKFETLSQYKSSVPSGYTSLVRGFGNFIRSFSSEAPPAVSDQMSLIKQLRERTSAPIKDVKASLVECNWDLEAAQKDLRKRGKVLASKKSSRTAAEGMLAVAQNEGKVAVIELNCETDFVARNEIFQYLALAMAKHALLVESSSQQVSGVFPFGPELFEEFKLNLDHPKVNGETTVSNAVTEVAAIMGENVKFRRGFLMSKSSAGVLSAYLHTSPQPGLGRIAGIVSLEVEGENTQLEAIQRVGSELAMHVVAAKPLFLSKDLVSSEAMANEREILKSQAESTGKNQMAIEKIVEGRLRKYFEEVALMEQKFIVNDAINIKTLVDNLSKEVGSPVKVTDFLRVEVGEGIERLEASDEPVAQTA
Protein: Uncharacterized ABC transporter permease Rv2563 (P9WG15)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized ABC transporter ATP-binding protein Rv2564
- Uncharacterized ABC transporter ATP-binding protein Rv0073
- Uncharacterized ABC transporter ATP-binding protein Rv0986
- Conserved protein
- Proline-rich antigen homolog
Sequence:
MLFAALRDVQWRKRRLVIAIVSTGLVFAMTLVLTGLVNGFRVEAERTVDSMGVDAFVVKAGAAGPFLGSTPFAQIDLPQVARAPGVLAAAPLATAPSTIRQGTSARNVTAFGAPEHGPGMPRVSDGRAPSTPDEVAVSSTLGRNLGDDLQVGARTLRIVGIVPESTALAKIPNIFLTTEGLQQLAYNGQPTISSIGIDGMPRQLPDGYQTVNRADAVSDLMRPLKVAVDAITVVAVLLWIVAALIVGSVVYLSALERLRDFAVFKAIGVPTRSILAGLALQAVVVALLAAVVGGILSLLLAPLFPMTVVVPLSAFVALPAIATVIGLLASVAGLRRVVAIDPALAFGGP
Protein: Ribosomal protein S4 (Ribosomal protein small subunit 4) (Q2F973)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MPALRFKTCRLLPGNVRNRELSLIQRRILRRLRNKRRSIKRNLSQRENLNSNIKSQTTRKLSLYYGDLPIREMHRGRERTSYIPFLLNQETRSDVIPVRLHFCDTLPQARQPISHRRVCLNNGLVTITHLKVSHGDLISFQENDARTRGEEIRRSFYIDISVGKIIGKLLPVRIWRKTKTEWFRLLTTQRVCRLLLKSWFLQELRSYMQEEDLERTKKFGSAKVCLGSSFAEHNRMKRNLFHFKYFFLLKRRKEEEELIRTIGEAENRKRAISPFVYKSSLYRNSTYCSGSPFTRKIRIKRIELPTHYSEVNHRTLKAVVSYGPNIGHIPHDIRLKDPNLPLRSGNGRGQNI
Protein: Nitric oxide synthase-interacting protein (A0A075B6F9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR023577}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR023577}.
Interaction partners:
Sequence:
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPGDSDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA
Protein: Nitric oxide reductase subunit B (EC 1.7.2.5) (NOR large subunit) (Nitric oxide reductase cytochrome b subunit) (P98008)
Organism: Stutzerimonas stutzeri (Pseudomonas stutzeri)
Function: Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification). NorB is the catalytic subunit of the enzyme complex. Shows proton pump activity across the membrane in denitrifying bacterial cells. The mononitrogen reduction is probably coupled to electron transport phosphorylation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSSFNPHLKFQSQAVAKPYFVFALILFVGQVLFGLIMGLQYVVGDFLFPLLPFNVARMVHTNLLIVWLLFGFMGAAYYLIPEESDCELHSPKLAIILFWVFAAAGVLTILGYLFVPYAALAEMTRNDLLPTMGREFLEQPTITKIGIVVVALGFLYNIGMTMLKGRKTVVSTVMMTGLIGLAVFFLFAFYNPENLSRDKFYWWFVVHLWVEGVWELIMGAMLAFVLIKVTGVDREVIEKWLYVIIAMALITGIIGTGHHFFWIGAPTVWLWVGSIFSALEPLPFFAMVLFALNMVNRRRREHPNKAASLWAIGTTVTAFLGAGVWGFMHTLAPVNYYTHGSQLTAAHGHLAFYGAYAMIVMTMISYAMPRLRGLGEAPDARAQRIEVWGFWLMTISMIAITLFLTAAGVVQIWLQRIPADGAAMSFMNTADQLAIFFWLRFIAGVFFLIGLVCYLYSFRQRGRVPVVVAAPAAA
Protein: Type 4 fimbrial biogenesis protein PilW (G3XD15)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Type 4 fimbrial biogenesis protein PilX
- Type II secretion system protein H
- Type 4 fimbrial biogenesis protein PilV
- Type IV pilus non-core minor pilin PilE
- Type IV pilus biogenesis factor PilY1
- Type 4 fimbrial biogenesis protein PilY2
- Type II secretion system protein H
- Type IV pilus inner membrane component PilP
- Type IV pilus inner membrane component PilO
- Type IV pilus inner membrane component PilN
Sequence:
MSMNNRSRRQSGLSMIELLVALAISSFLILGITQIYLDNKRNYLFQQGQAGNQENGRFAMMFLDQQLAKVGFRRRADDPNEFAFPAQQKTAYCEAFKAGSTLVPAVVKAGQSGFCYRYQPAPGEAYDCEGNSITTPSDPFATAQAITARVLFVPATADVPGSLACSAQTIKEKGQEIVSGLVDFKLEYGVGPTMAGKREVESFVEQANIADRPVRALRYSALMASDKNLRQGDSKTLDDWITLYPSSKTSLQGNDKDRLYQIAKGSQTLRNLVP
Protein: Two pore segment channel 2 (F1MAS6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAAEAQPLLGRDRGGGQAHSGADQELCIDQAVVFIEDAIKYRSIYHRLDAGSLWLYRWYYSNVCQRVLGFTIFLILALAFVEVPSSFTRTADVRYRSQPWQPPCGLTETIEALCLLVFLADLSVKGYLVGQAQLQQNLWLLAYFVVLVVSVVDWIVSLSLNCEESLRVRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLTIHLCLFTVIGMLLFTIAEKDEAQNKERLTYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAYALFFIIFTLIGSLFLMNLLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLTLQAGPNGTTSELVGVNPENFLRVLQKTQLNKIHKQAIIQKVHSYEGRPILADEFQKLFDEVDKGIVKERPPKPQYQSPFLQTAQFIFSHRYFDYLGNLIALGNLLSICVFLVLDSNLLPGERNDFVLGILNYIFILYYLLELLFKVFALGLRGYLFYHSNVFDGLLTIILLVLEISTLAVYRLPHPGWKPEQYGPLSLWDMTRLVNILIVIRFLRIIPSIKPTAVVASTILGLIQNLRAFGGILVVVYYVFAMIGINLFRGVIVPPGNSSLVPDNSSAPCGSFEQLGYWPNNFDDFAAALITLWDVMVVNNWQVILEAYKHYSGPWSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQGHKQLLVGTKQITYEMSVELMFRDILEEPKEEELMEKLHKHPHLHLCR
Protein: Paired box protein Pax-6 (A0A1W2PRG3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNQNVSNGCVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRL
Protein: Olfactory receptor 2A4 (Olfactory receptor 2A10) (Olfactory receptor OR6-37) (O95047)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
Sequence:
MGDNITSIREFLLLGFPVGPRIQMLLFGLFSLFYVFTLLGNGTILGLISLDSRLHAPMYFFLSHLAVVDIAYACNTVPRMLVNLLHPAKPISFAGRMMQTFLFSTFAVTECLLLVVMSYDLYVAICHPLRYLAIMTWRVCITLAVTSWTTGVLLSLIHLVLLLPLPFCRPQKIYHFFCEILAVLKLACADTHINENMVLAGAISGLVGPLSTIVVSYMCILCAILQIQSREVQRKAFRTCFSHLCVIGLVYGTAIIMYVGPRYGNPKEQKKYLLLFHSLFNPMLNPLICSLRNSEVKNTLKRVLGVERAL
Protein: Claspin (G3MU54)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MENVYEAEEGDADDVPDNDTIRRQNHKLLLKQENDKEQRELAKLQDRLLADGDLGGVETNRQFRFKLREEVQIQMGDDVDGNDGDGEDDEPEEDEQKKKERAEMIKFKYEHAEELMLLDEPKQGDDMFARAGKLFKKTEKTVIEFSEETMFKPRLSKPSLLSKTTLAVTFQEVLNGPGGAAKQMYVQSFEKPTPLSTGHISSPSSRLSTGKRLLKSPESSASAKRVRSSKLSSLE
Protein: Probable G-protein coupled receptor 32 (O75388)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Hematopoietic SH2 domain-containing protein
- Polyunsaturated fatty acid lipoxygenase ALOX15
Sequence:
MNGVSEGTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMARTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQWLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVWALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTRKWNGCTHCYLAFNSDNETAQIWIEGVVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKLLREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRVMLKEIYHPRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSSCPRGNAPRE
Protein: Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) (Q9CQM9)
Organism: Mus musculus (Mouse)
Function: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O76003}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18258855}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:18258855}. Note=Under the plasma membrane (PubMed:18258855). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (PubMed:18258855). In the Z line, found associated with CSRP3 (PubMed:18258855). {ECO:0000269|PubMed:18258855}.
Interaction partners:
- BolA-like protein 2
- BolA-like protein 1
- Anamorsin
- T-complex protein 1 subunit delta
- Iron-sulfur cluster assembly enzyme ISCU
- COP9 signalosome complex subunit 5
- Cysteine desulfurase
- Glutaredoxin-related protein 5, mitochondrial
- LYR motif-containing protein 4
- Frataxin, mitochondrial
Sequence:
MAAGAAEAGEAAVAVVEVGSAQQFEELLRLKTKSLLVVHFWAPWAPQCVQMNDVMAELAKEHPHVSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRLDGAHAPELTKKVQRHVSSGAFPPSTNEHLKEDLSLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN
Protein: Atlastin GTPase 3 (F5GWF8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRTAGRDPVSAGLQFPKDGSTQRPANRARFVPARTRPSPLHPCCFCFEGGGSMLSPQRVAAAASRGADDAMESSKPGPVQVVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQKESGHSNWLGDPEEPLTGFSWRGGSDPETT
Protein: DNA polymerase kappa (EC 2.7.7.7) (Meiotically up-regulated gene 40 protein) (O74944)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Has a role in meiosis.
Subcellular location: Cytoplasm. Nucleus. Note=Associates with chromatin.
Interaction partners:
- DNA repair protein rev1
- DNA polymerase zeta catalytic subunit
- Proliferating cell nuclear antigen
- DNA polymerase zeta processivity subunit
- N-acetyltransferase eso1
- Inheritance of peroxisomes protein 2
- DNA polymerase epsilon catalytic subunit A
- DNA repair protein rad16
- Mating-type switching protein swi10
- DNA repair protein rad14
Sequence:
MENAKDFIGETIKENGLLTIEDDGSSSSDEEATLKRRLAGPSVLKSGQENVNQKKINEIIYEASKGSKFFEAEQKRDRELRLRIEKVQVEVEKYQSKLRFDKAFQREWTIRQESVDTTVEDFRAKRDLTQIIVHVDCDAFYASIEELKNPKLKSLPMAVGKSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLQELAFTVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQFFIPFDEIGISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGFGTTILDEYGESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKPALQLLRQSYPMTIRLLGVRATKLVSKSRCLAMQLKFQSQNTVPCPVCQKNIENELGILNQHVDLCLNVETVKSLINTDHTANPTIKKRKSNTLDTYFLE
Protein: WD repeat domain 6 (V9GYU1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIV
Protein: SWIB complex BAF60b domain-containing protein (F4J9Z9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVSDLDLVTRLREILGSSDLNTATPASVRRQLEADFGVDLTDKKAYIRDQIDTFLESNGAVEDKPESPKVEEYINADEIKAEIEGGDGEDLDGDGSGSEEEKEERPVKAKKRGGGITKVSQLSPQLEKVVGASQLGRTEVVKKMWAYIREKDLQDPKDRRKIVCDELLHSLFRVKTINMFQMNKALTKHIWPLGDGDGCANDVKEEDEDEASEGTDKKGEQSEEVEENKEEESEEQEVRSLRKRKRKKPAKSVEKPKRKGGGGFAKVCSLSPELQAFTGVTELARTEVVKLLWKYIKENNLQDPNDKRSIICDESFRSLFPVESINMFQMNKQLTKHIWPLEDNAGESVSSKSPKNGKQKMESDGDSEEPNEKDKKQKKEVLAPLPLSDALVKFLGDGENSLSRADVVKRLWEYINHNDLQDPSDKRRVICDEKLKELFEVDSFEDTSVSKLLTNHFIKAEQ
Protein: E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) (Q9H4P4)
Organism: Homo sapiens (Human)
Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 8
- Receptor tyrosine-protein kinase erbB-3
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
- Protein CLEC16A
- Ankyrin repeat and SOCS box protein 6
- Vacuolar protein sorting-associated protein 52 homolog
- E3 ubiquitin-protein ligase parkin
- Receptor tyrosine-protein kinase erbB-4
- Insulin-like growth factor 1 receptor
- Calcyclin-binding protein
Sequence:
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
Protein: Vacuolar protein sorting-associated protein 71 (SWR complex protein 6) (Q03433)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Participates in the catalytic exchange of histone H2A for the H2A variant HZT1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- SWR1-complex protein 4
- SWR1-complex protein 5
- Vacuolar protein sorting-associated protein 72
- RuvB-like protein 2
- Helicase SWR1
- Protein AF-9 homolog
- Actin-like protein ARP6
- RuvB-like protein 1
- SWR1-complex protein 7
- SWR1-complex protein 3
Sequence:
MKALVEEIDKKTYNPDIYFTSLDPQARRYTSKKINKQGTISTSRPVKRINYSLADLEARLYTSRSEGDGNSISRQDDRNSKNSHSFEERYTQQEILQSDRRFMELNTENFSDLPNVPTLLSDLTGVPRDRIESTTKPISQTSDGLSALMGGSSFVKEHSKYGHGWVLKPETLREIQLSYKSTKLPKPKRKNTNRIVALKKVLSSKRNLHSFLDSALLNLMDKNVIYHNVYNKRYFKVLPLITTCSICGGYDSISSCVNCGNKICSVSCFKLHNETRCRNR
Protein: NADP-specific glutamate dehydrogenase (NADP-GDH) (EC 1.4.1.4) (NADP-dependent glutamate dehydrogenase) (P18819)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Glutamate synthase
- Glutamine synthetase
- Glutamine synthetase
- NAD-specific glutamate dehydrogenase
- Aspartate aminotransferase
- Aspartate aminotransferase
- Glutamate pyruvate transaminase
- aspartate transaminase
- Glutamate decarboxylase
- Glutamate decarboxylase
Sequence:
MSNLPVEPEFEQAYKELASTLENSTLFEQHPEYRRALQVVSVPERVIQFRVVWENDKGEVQINRGYRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCTAFMTELCKHIGADTDVPAGDIGVTGREVGFLFGQYRRIRNQWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIKHVTGGKESFAGKRVAISGSGNVAQYAALKVIELGGSVVSLSDSKGSLIVKDESASFTPEEIALIADLKVARKQLSELATSSAFAGKFTYIPDARPWTNIPGKFEVALPSATQNEVSGEEAEHLIKSGVRYIAEGSNMGCTQAAIDIFEAHRNANPGDAIWYAPGKAANAGGVAVSGLEMAQNSARLSWTSEEVDARLKGIMEDCFKNGLETAQKFATPAKGVLPSLVTGSNIAGFTKVAEAMKDQGDWW
Protein: Catenin delta-2 (O35116)
Organism: Rattus norvegicus (Rat)
Function: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:20623542}. Perikaryon {ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:20623542}.
Interaction partners:
- Transcription factor 7 like 1
- Lymphoid enhancer-binding factor 1
- Transcription factor 7 like 2
- Transcription factor 7
Sequence:
FPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVG