wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17) (Q6P1E1)
Organism: Mus musculus (Mouse)
Function: Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9ULJ6}. Cytoplasm {ECO:0000250|UniProtKB:Q9ULJ6}. Note=Enriched at replication foci throughout S phase. {ECO:0000250|UniProtKB:Q9ULJ6}.
Interaction partners:
Sequence:
MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMSTSNPGINSPQFAGQQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSLNPAGMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQAGPPLHHSGAPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN
Protein: DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (Q54PN5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA excision repair protein ERCC-1
- DNA repair protein Rad4 family protein
- Probable crossover junction endonuclease mus81
- Fanconi anemia group D2 protein homolog
- Replication protein A subunit
- DNA topoisomerase 3
- Fanconi-associated nuclease 1 homolog
- RING-type domain-containing protein
- DNA 3'-5' helicase
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
Sequence:
MSLEFYKQIFEDCLNDDGLVVMGSGLGIHNIILGFLKFYSDTDDLVLFLDCQSNESLQNSYLFYHERLLNFGIKYSNLPTMVNVETVSSSTKTNMYSKGGVYFGASSIFVLDYLTKRMPCNLVSGIIIQNAHRITDTSIEYLLIKLFRQNNKKGFIKAFTTEPSLLVDEIGKLQRTMKYLHLKKLFLWPRFHQHISLILDKHPPDLVELSIGMTNSMKRIEESLHLNTQRCISSLIAINKLPRLNGGNGGNDSDSFEQILKQQLKPMWSKLNLHSKQLVSSIKLLNQLKNNLLVYDCVTFYSLLLYIQASSDSLKEGLHTNSNYVDEVQPWLESKEAQNLFSASQERVYRFKKLNSLKSPPKKLKTINNDSSSSSSSSNLEKILTLEDNPKWNVLYQILQEIEEDKEKQGTILIFVKDETTVNQLSTYLDYGGYSFLLGKYEKLCSNQQYLDELRKKKEENNNNNNSNNNNNNNNNNNNNNSVKSLSSNDNGGYSRYRRTKNFKDNRKQQIIETSKKKKGKGGTNDQNLFNMGIQLVDGHNKLNIPNPKFINQDGSGGGGDNGDENNNNNNNLNINDGLTIASMNEEINGLNDFYELLSPPYIVIHPISKSLTILDEIRPTFIIVYDPDISITRQIEVYKAENPGTPVRLYFMTYSDSSEEYQYISKLQREKSSFEKLIREKTNLIIDTEQEGKIQLVDNSKLELLDDMKSTRNSRLGGLMKNFDSIQQQQQQQQQKKTIIIDSHEFKSSLPVVLHNNGYEIIPLRLEVGDFVLSPIHCIERKSVSDLIGSFNSGRLFTQIEAMNRIYKNPILLIEFDPNQPFYLVAPDELQKDYLSPFSLPSKLVFLTKTFPRLRVIWSRSYYCTTKIYDQIKDGYPEPDPSMVNVIPEVNDDQNYNFNAQDVLRTMPGVNDKNINLIMDNVDDLYHLSKLSLSEFSTIMNDSVNNNKNATLLFNFFNNQLNQ
Protein: cAMP-dependent protein kinase type II-beta regulatory subunit (P31324)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. {ECO:0000250}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- cAMP-dependent protein kinase type I-beta regulatory subunit
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- Hormone-sensitive lipase
- A-kinase anchor protein 1, mitochondrial
- A kinase
- cAMP-dependent protein kinase catalytic subunit PRKX
- A-kinase anchor protein 10, mitochondrial
Sequence:
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
Protein: Uncharacterized protein (Q585R6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLIGMKYSAPKAIVISLHFPKSRFPYIGTHFHVECYEGDGPWKHLLQPAECWCSKLLTGKKCTTTARHRGMPRTFEVPMSVMGIHNRKRILNRGIFIFVPNRIYFINNREFLLTRRTCVYFDTTANTFPKKKNTCTMVGTKCSHLCTIKTSYSVEIKSLKETKRKNQIPFEMNITFAPL
Protein: Synaptotagmin-like protein 2 (Exophilin-4) (Q99N50)
Organism: Mus musculus (Mouse)
Function: Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane.
Subcellular location: [Isoform 1]: Melanosome membrane {ECO:0000269|PubMed:15543135}; Peripheral membrane protein {ECO:0000269|PubMed:15543135}. Note=Bound to melanosomes. Isoform 1 is localized mainly on peripheral melanosomes but not on less mature melanosomes around the nucleus. {ECO:0000269|PubMed:15543135}.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane {ECO:0000269|PubMed:11243866, ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782}. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. {ECO:0000269|PubMed:17182843}.
Interaction partners:
- Ras-related protein Rab-27A
- Melanophilin
- Ras-related protein Rab-27B
Sequence:
MIDLSFLTEEEQDAILKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRRKKLPAAAEQNKDTAMRAKESWVNNVNKDAVLPPEIAVVEEPEDDTDPAGPSSSLVDPASSVIDMSQESTRTPAVSLPKQRKNPFNSPKLPEDHSLQQTKPEQSKTGKAGLFQISKEGELSESKEKSSIPDMPRQQLEKPKQTVSTEPENASHTKAPIPKARKLIYKSNDLEKDDNQSFPRQRRDSLNARGAPRGILKRNSSSSSTDSETLRLNYNLDPKSKILSPGLTIHERISEKEFSLEDDSSTSSLEPLKHVRFSAVKNELPQSPRPVLGQEVGEFTVLESDQLQNGTEDAGDIEEFQNHPELSHKTPLSHYQLVSSPSDSGREREQLMSSGSAPRDEIPCHSDILPTGPQCVESSSVINGQQEKSSHFTKLPSELSKSPSDELTQCGEPEPSQTADHSFRDHRQGSEEEHSPVLKTLERRAARKLPSKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVPSLPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLRRYKKSPSSLTNLSSSSGMTSLSSASGSVMSVYSGDFGNLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDSKQNKQLKWYPLKRKTAPVALETENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWVEATLPLRMLLIAKLSK
Protein: Tetratricopeptide repeat domain 21B (Tetratricopeptide repeat protein 21B) (B0R0W1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- WD repeat-containing protein 35
- WD repeat domain 19.
- Intraflagellar transport 140 homolog
- Intraflagellar transport 80 homolog
- Intraflagellar transport 88 homolog.
- Intraflagellar transport protein 172 homolog
- Dynein cytoplasmic 2 heavy chain 1.
- Cytoplasmic dynein 2 intermediate chain 1 isoform X2
- Intraflagellar transport 81 homolog.
- Meckelin isoform X1
Sequence:
MASVEDDENCALALILYYCQEKYSSHVVDVSSEAQRKFSPDPIFTFLHAYGLLMQDQVLDAIQELEMLKERRDVSLCALMALVYAHKKRPNPDREIIQDLDGRVKEERKTASPKALYYAGMLLWLLGRNDKAREYVDRMIKISSGSKEGIVLKGWIDLRSNKDAYAKKSGKYFDEALKEKSDIFALMGKVHYYEYRQNYSGALDTINQVIVSYPSFLPALVKKMKLLLTLQDWEQTVDAAQRLLQREKNNLEALRMQALHALCRDGDIAESVNQLSNLISNLDIQEPSNPELFYRMSLAFTRVCGRAEKILQHTHRMVERAFAQASSDSELATEMGYQLILMGRVKEAMKWYKTAMTLDESSVSALIGIIRCQLIEGHIEDAEQQLEFLTEIQQSIGKSGELLYLRALLAVKKRRPPDEVTNLLNDTVDTHFSALQGLPLSVEYFEKLNPDFLLEIAKEYLALCPAKSPALSQPSSPQLQHAASVLDTVMKVVPGLLQAVFLMARVRFQSGDIDAAQSSLQHCLDQNPAHADAHLLMAQIHLIQGNYKLSSQSLELCLSHNFEIREHPLYHLIKAQAQRKMGQLQEAIQTLQMAMSLCAVKRTGSSAKRQSKRVELSSADCVSVFLELAEALWLNGEQHEAAKVMQDAINEFTGTPEELRVTIANADLALMRGDTELALSMLRNITPEQPYYIQAKEKMADIYLNHRKEKRLYVSCYRELVDKMPNPHSFLLLGDAYMNIQEPELAIEVYEQALKKNPKDGALASKIGKALVKTHNYVKAINYYEAALKSGQQNFLRYDLADLLMKLRQYERCEKVLQEALAHDPVIELPLLTEDCRYLVLLAKVQSKVIKNDEALLSLQRARDVQAKVLKRVQLEQPDSVPAQKQLAAEICAEIAKHCSSQRGYERAVKFYKEALVYCENDSKVMLELAQLYLTLDDVEACQQQCSAILKNDPVNESATLMMADLMFRKQDYEQAVFHFQQLLERKPDNYPTLSRLIDLLRRAGKLEEVPRFLEMAEKHSSRAKFEPGYNYCKGLYLWYTGEPNDGLRHFNKARKDNDWGQNAVYNMIEICLNPDNETIGGEVFENLDGDMGNSTEKQESEQLAVRTAEKLLKELKPQTPVGHVQLRILENYCCLATKQKANVERALNVFIEIANTEKDHVPSLLAMATAYMILKQTPRARNQLKRIAKMNWNIIDADEFEKSWLLLADIYIQSGKYDMAGDLLKRCLRHNKSCCKAYEYMGYIMEKEQSFRDAAMNYEMAWKYSNQTNPTIGYKLAFNYLKAKRHVDAIDVCHKVLDAHPNYPRIRKDILDKARSALRS
Protein: Transcriptional regulator MexT (Q9I0Z0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Resistance-Nodulation-Cell Division
- Probable oxidoreductase
- Efflux pump membrane transporter
- Multidrug efflux outer membrane protein OprN
- NalD
- NalC
- HTH-type transcriptional regulator NfxB
- Outer membrane protein OprM
- Outer membrane protein OprJ
- Multidrug resistance operon repressor
Sequence:
MPVSDPMPLRHLARPRPVSHARLDGEPPRLQPLAPGNEERHEPKRPAPRRSEPADRVRDPDARTQRDPRRRETVPRPAGQPAISAALSRLRTLFDDPLFVRTGRSMEPTARAQEIFAHLSPALDSISTAMSRASEFDPATSTAVFRIGLSDDVEFGLLPPLLRRLRAEAPGFVLVVRRANYLLMPNLLASGEISVGVSYTDELPANAKRKTVRRSKPKILRADSAPGQLTLDDYCARPHALVSFAGDLSGFVDEELEKFGRKRKVVLAVPQFNGLGTLLAGTDIIATVPDYAAQALIAAGGLRAEDPPFETRAFELSMAWRGAQDNDPAERWLRSRISMFIGDPDSL
Protein: Glutaredoxin-C11 (AtGrxC11) (Protein ROXY 4) (Q9LYC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- AT5g19120/T24G5_20
- GDSL esterase/lipase At1g58430
- Ras guanine nucleotide exchange factor Q-like protein
- Probable lysophospholipase BODYGUARD 3
- Transducin/WD40 repeat-like superfamily protein
- Probable magnesium transporter NIPA2
- DnaJ domain protein
- Thioredoxin-like protein CXXS1
- At2g17880
Sequence:
MERIRDLSSKKAAVIFTKSSCCMCHSIKTLFYELGASPAIHELDKDPEGREMERALRALGSSNPAVPAVFVGGRYIGSAKDIISFHVDGSLKQMLKDAKAIWL
Protein: Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) (Q13951)
Organism: Homo sapiens (Human)
Function: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q08024}.
Interaction partners:
- Runt-related transcription factor 3
- Elongin-C
- Elongin-B
- Runt-related transcription factor 1
- Cullin-5
- Runt-related transcription factor 2
- RING-box protein 2
- Myosin-11
- DNA dC->dU-editing enzyme APOBEC-3F
- DNA dC->dU-editing enzyme APOBEC-3G
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP
Protein: LHFPL tetraspan subfamily member 1 protein (Lipoma HMGIC fusion partner-like 1 protein) (Q86WI0)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRSSLTMVGTLWAFLSLVTAVTSSTSYFLPYWLFGSQMGKPVSFSTFRRCNYPVRGEGHSLIMVEECGRYASFNAIPSLAWQMCTVVTGAGCALLLLVALAAVLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQLGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVILVESIMRNTNSYAMELDHCLKP
Protein: TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) (Q90999)
Organism: Gallus gallus (Chicken)
Function: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P37173}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P37173}. Membrane raft {ECO:0000250|UniProtKB:P37173}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-3 proprotein
- TGF-beta receptor type-1
- Transforming growth factor beta-2 proprotein
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog 3
- ZP domain-containing protein.
- Uncharacterized protein.
- Mothers against decapentaplegic homolog
- Transforming growth factor beta receptor 3
Sequence:
MPPRLRPLLLRVSLWVLVGSSSPALLHDRSKENGLQLPRLCKFCDVKATTCSNQDQCKSNCNITSICEKNNEVCAAVWRRNDENVTLETICHDPQKRLYGHMLDDSSSEQCVMKEKKDDGGLMFMCSCTGEECNDVLIFSAIDPHKPEEKDEISKVTIISLVPLLVISVAVIVIFYAYRTHKKRKLNKAWEKNVKPKKHKDCSDVCAIMLDDDHSDISSTCANNINHNTELLPIELDIVVGKGRFAEVYKAKLKQNTSEQYETVAVKIFPYEEYASWKTEKDIFSDVNLKHENILQFLTAEERKTDLGKQYWLITAFHARGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHSDHTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPSLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNGVGEVKEYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLIECWDHDPEARLTAQCVAERFSEFKHHDKLSGRSCSEEKIPEDGSVTTAK
Protein: Heat shock cognate 70-kd protein, tandem duplicate 3 (Hsp70 protein) (Q6PH56)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Heat shock protein HSP 90-alpha 1
- E3 ubiquitin-protein ligase CHIP
- BCL2-associated athanogene 3.
- Heat shock protein beta-1
- Heat shock protein b8
- Heat shock protein HSP 90-beta
- DnaJ heat shock protein family
- 60 kDa heat shock protein, mitochondrial
- Heat shock factor protein 1 isoform X1
- DnaJ heat shock protein family
Sequence:
MSSPKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPNNTVFDAKRLIGRRFDDPVVQSDMKHWSFKVVSDGGKPKVAVEHKGENKTFNPEEISSMVLVKMKEIAEAYLGQKVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGKSSERNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFKRKHKKDISQNKRALRRLRTACERAKRTLSSSSQASIEIDSLYEGIDFYTSITRARFEELCSDLFRGTLDPVEKALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAAVQAAILMGDTSGNVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKQTQTFTTYSDNQPGVLIQVFEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAADKSTGKQNKITITNDKGRLSKEEIERMVQEADKYKAEDDLQREKISAKNSLESYAFNMKNSVEDDNLKGKISEEDKKRVIEKCNEAVSWLENNQLADKEEYEHQLKELEKVCNPVISKLYQGGMPAGGCGAQARGASGASAQGPTIEEVD
Protein: G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) (E1BNE9)
Organism: Bos taurus (Bovine)
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G protein-activated inward rectifier potassium channel 4
- Gamma-aminobutyric acid type B receptor subunit 2
- G protein-activated inward rectifier potassium channel 2
- Gamma-aminobutyric acid type B receptor subunit 1
- Guanine nucleotide-binding protein G
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Guanine nucleotide binding protein
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQSEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGATRMEGNLPAKLRKMNSDRFT
Protein: NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2) (Q99KE1)
Organism: Mus musculus (Mouse)
Function: NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P23368}.
Interaction partners:
- Malate dehydrogenase, mitochondrial
- Malate dehydrogenase, cytoplasmic
- Fumarate hydratase, mitochondrial
- Pyruvate carboxylase, mitochondrial
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- L-lactate dehydrogenase A chain
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Sequence:
MFSRLRAVTTPCTLTCRRVHLKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYQQKYCTFNDDIQGTAAVALSGLLAAQRVINKPVSEHKILFLGAGEAALGIANLIVLSMVESGLSEEEAQRKIWMFDKSGLLVKGRTASIDSNQEPYAHAAPESIPATFEDAVNKLKPSVIIGVAGAGPLFTHGVIKAMASINERPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFEPVKLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTTQLTDAELAQGRLYPSLANIQEVSANIAIKLAEYLYANKMAFRYPEPEDKARYVRERIWRSNYVSLLPDVYDWPESSLTPPQITEEKLPH
Protein: Misexpression suppressor of ras 4, isoform D (A0A0B4LGV3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMEALDQQQAKLTSNRDDGEAGRGSETGSEEGTGAGAAAGEEDDIEELHYVLDQAKEENESHQHGQNNNAKGNEDGKPKKNDDVIDVTMANGQGFKDTPEEETTGTEETAETEETAETEEAEQAEESLLNSRKSTDTPVDLGANCLTTGSPSKDLVKQELVEDKSEELKEPTSISLNEQFLDDIELKTEVEDKSDSLSETHMEFLTDSEEQPSESLGANHESEIDEKVDHFQPKESDSNEVEDKYFQSANEDSESEIEETVYTPPVINLETDSESGDKEFISIKDNESPVLEIEGGTEKSQTSGDLYQADVGEYASTAPPEVDETTSQTIGVPSLEGSDTLDSPSLTMDVDLPCSEDGAPPNVIKIESDMEDEAHSDSVKLKEHTVEVVPLIKLNGAHKALKEEKLEDGEVEEVEDPGEELEDPKEQSVITNHTGNNTKEEDTTASQVSALPLILPVGTTRSRSISSRSSTVSSASQPHLVIDHPESEHNAKPPALKLSLKRRRSKSSSVSQPEKQTKVEAGGFVSSLLLQRLQSNSNVIPPAISTESQQVLSCAKCNLQFDFERFQELNKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSVHQCWHFFLHMREVHRRYICLYCNHVYPSVEKLSLHLENKHDIDQSHFAKDAWDQQQSSEFEDHDCSQLMQPCALCNQKGGHIIGCKNNKRKPTKRRRKVRRPPEPPLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDIQNPFPAENIPAPEPVEDPPAPPIPKLVVPKIMLRVPKEFQKSVDAALSSTDTEDEELETAQPVEEAVSAPPEDLPFDAPPPPPPALSYDDSTSSKLNRVLAELERTKLDIERTKADIITKKQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVNLPEPPPALITEFQGQPDAVRRNSLGSDCMDMDDSLNAPEMEGSRDFTEAQKETLEPAPPSQDTQTADEPLAIQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDFVRLCLKSVYSLCLYCNHARRIAVNVKQLVIHLIGQHRFTATVDSITAEELYAETIVAKLKSFLPNLENEYMNAASCCSLENGKYVEPFNERIYECFTCRFVTSTHKELYTHNRRLHIKSNITCVMCQTNFYSYSEILCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRLMVHLRKQHQACDICLEDCQSQSKLSSHVWKHKLLHLCYRCGIAYRNKQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSHVAKELPQAVSVEQTADAAPTEKLEDIKEELEEGEDEKEGAHNQEKLLSESLTNNETPKKEESDRIDNSIEPPLSKSENRKRRKKSKRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKSKLEDKEEKPLDGSTEEKALDADDELEPKKEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANKSSIKTPGENASSDSDSSSSSSSSDSDSSSCSCGSNCSCSSSNSSSSSGNSDDSDSSTARGSPQKRSRKKSLKVKKSSESLKIDQNGQNEQNQVEDTTAVNENNNPVAPPSPKPPMYNESDFDTAFSDTDEEFYDSHPQKLANELLTQKREALMAEHAPMRPSNNYDIVENSRPSTPSLPEEASAFADKREKVRNKKKKRERKSTCKSGKLQPVASTTPPPMDRIPGMPGMIAPLEPPTPILSHPESSLFPVTPLTHRQLQSSMTRMSEGSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQVGMQLIKPQPPPQLTWAKEDLPTPPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKPDPNDHLPPIPTLKIRPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVALPVPPPPPPAATAFNQPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCYCRCPYDEVSEMIACDGDNCLIEWFHFECVGIMVAPQGKWFCAECRPKYSEGIYQGAKPQ
Protein: Large ribosomal subunit protein eL8y (60S ribosomal protein L7a-2) (Q9LZH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein eL31z
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL10y
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein uL4z
- Large ribosomal subunit protein uL1x
- Large ribosomal subunit protein uL10x
- Large ribosomal subunit protein eL32z
Sequence:
MAPKKGVKVASKKKPEKVTNPLFERRPKQFGIGGALPPKKDLSRYIKWPKSIRLQRQKRILKQRLKVPPALNQFTKTLDKNLATSLFKILLKYRPEDKAAKKERLLNKAQAEAEGKPAESKKPIVVKYGLNHVTYLIEQNKAQLVVIAHDVDPIELVVWLPALCRKMEVPYCIVKGKSRLGAVVHQKTAAALCLTTVKNEDKLEFSKILEAIKANFNDKYEEYRKKWGGGIMGSKSQAKTKAKERVIAKEAAQRMN