wanglab/gogpt-training-data huggingface dataset:
Protein: Intelectin-1a (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (O88310)
Organism: Mus musculus (Mouse)
Function: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind mammalian glycans. Probably plays a role in the defense system against microorganisms. May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8WWA0}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8WWA0}. Secreted {ECO:0000250|UniProtKB:Q8WWA0}. Note=Enriched in lipid rafts. {ECO:0000269|PubMed:16866365}.
Interaction partners:
- Lactotransferrin
Sequence:
MTQLGFLLFIMVATRGCSAAEENLDTNRWGNSFFSSLPRSCKEIKQEHTKAQDGLYFLRTKNGVIYQTFCDMTTAGGGWTLVASVHENNMRGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYFDIQAENLGIWHVPNKSPLHNWRKSSLLRYRTFTGFLQHLGHNLFGLYKKYPVKYGEGKCWTDNGPALPVVYDFGDARKTASYYSPSGQREFTAGYVQFRVFNNERAASALCAGVRVTGCNTEHHCIGGGGFFPEGNPVQCGDFASFDWDGYGTHNGYSSSRKITEAAVLLFYR
Protein: Serine protease 1 (EC 3.4.21.-) (Protein Jonah 99Cii) (C0HKF7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Major function may be to aid in digestion.
Interaction partners:
Sequence:
MKLFVFLALAVAAATAVPAPAQKLTPTPIKDIQGRITNGYPAYEGKVPYIVGLLFSGNGNWWCGGSIIGNTWVLTAAHCTNGASGVTINYGASIRTQPQYTHWVGSGDIIQHHHYNSGNLHNDISLIRTPHVDFWSLVNKVELPSYNDRYQDYAGWWAVASGWGGTYDGSPLPDWLQSVDVQIISQSDCSRTWSLHDNMICINTDGGKSTCGGDSGGPLVTHDGNRLVGVTSFGSAAGCQSGAPAVFSRVTGYLDWIRDNTGISY
Protein: Neogenin 1a (A0A0R4IP15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Hemochromatosis type 2
- Netrin-1
- Netrin-1
- Netrin 2.
- Repulsive guidance molecule A
- receptor protein serine/threonine kinase
- RGM domain family, member D.
- Netrin 4
- Netrin receptor UNC5
- Serine/threonine-protein kinase receptor
Sequence:
MAERGARLLLSLFCLTITVSHAEKGSAVRNFSPFWFSTEPSDTLAVRGAPVLLNCSVHSESPAKIEWKKDGSFLSLASDERRQVLADGSLLISSVVHSKHNKPDEGVYQCVATIDNLGTIISRTARLNVAGIARFLSQPEMASVRVGDSQVLSCEVNPDLVSFIRWEQNKEAVELDHRVFSLPSGALVISNATETDAGLYRCVIDNAGPTKTSEEAQLHILTETGEERTLEFLQEPQHVSKLVGESVLLPCVVTGYPTPEITWMYKDQLIEDSSGRFEILGGGSLRIFNLTEEDAGVYNCLAENTNGSIEAQAELTLKDSPQFLKKPVNVFAHEATDVIFECEVSGSPSPTIKWVKNGDAVIPSDYFKIIKEQNLQVLGLVKSDEGFYQCLAENDAGNVQSSAQLVILDQGSRGGAGPTPSAPRDVVASLVSTRFLKLTWRLPAEPHGDDVTYSVYYSLEGTNRERIVNTSRPGEMQVTIQNLMPDTKYAFRVVAHNKNGPGESSVPLKVETQPEVQVPGPAPNLHAVVMSPSTVSLSWDVPLIGNGEIQNYKIYYMEKGMDSEQDLDVNTLSYTMTGLKKFTEYSFRLVAYNKHGPGVSTEDISVRTYSDVPSSPPQNMTVEVLNSKSLMIRWQPPPADAQNGEITGYKIRYRKGTRKSEVAEITSGSQLYQLIDGLQRGTEYMLRVSAMTVNGTGPATDWTTAETFESDLDESRVPDVPSSLHVRSLVNSIVVSWTPPENQDIVVRGYSISYGIGSPHAQTIKVDYKQRYYTIENLNPNSHYVITLKAFNNVGEGIPVYESAITRPQSDPIDPDVDLYELFHAPYTPVPDPIPMLPPVGVQASVLNQDTIKVTWADNSLPKNQKITDARYYTVRWKTNIPANTKFKVANTTTLFHTVTGLKPNTLYEFSVMVTKGRRTSTWSMTAHGTTFESIPSSPPKDVTVVSKEGRPKTIIVNWQPPSEANGKITGYIIYYSTDVKAEVHDWVIEPVVGNRLTHQIQELTLDTTYYFKIQARNSKGMGPMSEAVQFRTPKAESSDKMANDQAPGISVKQGRPSAPDNGFGSPGKPDMSGTGDNHILVIVIIVSVGAFTIIVVVVGAFLCTRRTTTQQKKKRAACKSANGSHKYKGNSKDLKPPDLWIHHERLELKPIDKSPEPNPVMTDTPIPRTSQDITPVDGSMDPMLQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDAQPPQPVISAHPIHSLDNHHHHYHLGSLASPTRSYLHHQSSTRSIATPISHLDRAESTESVRNTPNAELLPPSGQPSCTTDLSETDISFHSSAAEEEPAFATPTAHVRPTHPLKSFAVPAIPAHAMYDSAALPSTPLLSQTGPHSVKTASIGTLGRTRTPMPVIVPNAPDVSEGCRLHEDAGSNYETDELSEEMAHLEGLMKDLNAITTA
Protein: Apelin receptor (Angiotensin receptor-like 1) (B78) (G-protein coupled receptor APJ) (GPCR34) (Q9JHG3)
Organism: Rattus norvegicus (Rat)
Function: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11359874}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P79960}. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:11359874). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P35414, ECO:0000269|PubMed:11359874}.
Interaction partners:
- Apelin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGGEPMHEKSIPYSQETLVD
Protein: Receptor-like protein kinase THESEUS 1 (EC 2.7.11.-) (Q9LK35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor-like protein kinase required for cell elongation during vegetative growth, mostly in a brassinosteroid-(BR-) independent manner. Mediates the response of growing plant cells to the perturbation of cellulose synthesis and may act as a cell-wall-integrity sensor. Controls ectopic-lignin accumulation in cellulose-deficient mutant backgrounds.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17540573, ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000269|PubMed:17540573, ECO:0000305|PubMed:17644812}.
Interaction partners:
- Rapid alkalinization factor 23
- Protein RALF-like 1
- Cellulose synthase A catalytic subunit 6
- Cellulose synthase A catalytic subunit 3
- GPI-anchored protein LLG1
- Protein MID1-COMPLEMENTING ACTIVITY 1
- Ferritin-4, chloroplastic
- GPI-anchored protein LORELEI
- Cyclase-associated protein 1
- GPI-anchored protein LLG2
Sequence:
MVFTKSLLVLLWFLSCYTTTTSSALFNPPDNYLISCGSSQNITFQNRIFVPDSLHSSLVLKIGNSSVATSTTSNNSTNSIYQTARVFSSLASYRFKITSLGRHWIRLHFSPINNSTWNLTSASITVVTEDFVLLNNFSFNNFNGSYIFKEYTVNVTSEFLTLSFIPSNNSVVFVNAIEVVSVPDNLIPDQALALNPSTPFSGLSLLAFETVYRLNMGGPLLTSQNDTLGRQWDNDAEYLHVNSSVLVVTANPSSIKYSPSVTQETAPNMVYATADTMGDANVASPSFNVTWVLPVDPDFRYFVRVHFCDIVSQALNTLVFNLYVNDDLALGSLDLSTLTNGLKVPYFKDFISNGSVESSGVLTVSVGPDSQADITNATMNGLEVLKISNEAKSLSGVSSVKSLLPGGSGSKSKKKAVIIGSLVGAVTLILLIAVCCYCCLVASRKQRSTSPQEGGNGHPWLPLPLYGLSQTLTKSTASHKSATASCISLASTHLGRCFMFQEIMDATNKFDESSLLGVGGFGRVYKGTLEDGTKVAVKRGNPRSEQGMAEFRTEIEMLSKLRHRHLVSLIGYCDERSEMILVYEYMANGPLRSHLYGADLPPLSWKQRLEICIGAARGLHYLHTGASQSIIHRDVKTTNILLDENLVAKVADFGLSKTGPSLDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLMEVLCCRPALNPVLPREQVNIAEWAMAWQKKGLLDQIMDSNLTGKVNPASLKKFGETAEKCLAEYGVDRPSMGDVLWNLEYALQLEETSSALMEPDDNSTNHIPGIPMAPMEPFDNSMSIIDRGGVNSGTGTDDDAEDATTSAVFSQLVHPRGR
Protein: Small ribosomal subunit protein uS14A (40S ribosomal protein S29-A) (S36) (YS29) (P41057)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS25B
- Small ribosomal subunit protein eS24A
- Small ribosomal subunit protein uS9A
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS12A
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS13A
- Large ribosomal subunit protein eL38
- Small ribosomal subunit protein eS12
Sequence:
MAHENVWFSHPRRYGKGSRQCRVCSSHTGLIRKYGLNICRQCFREKANDIGFNKFR
Protein: Rifin (Q8IJ06)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKFNYTNIILFSLSLNILLLSSRVYNKRNHKSIILHTSNENPIKTHRSLCECELYSPTNYDSDPEMKRVMQQFHDRTTQRFHEYDERMKTTRQECKEQCDKEIQKIILKDRLEKELMDKFATLHTDIQSDAIPTCVCEKSLADKTEKFCLNCGVQLGGGVLQASGLLGGIGQLGLDAWKAAALVTAKELAEKAGAAAGLKAGDIHGMKIVIEGLKALKVDTLKSGIFNSFVNNSHYTEVTGLAIAIDTEMNEVCSATYIGIHPICVVREKLGVIPKAGGTMVKQKDAITNVLKQALEKATQSAEALSETTAEDVAAKLTAQKTGAINTIFMSNQTAIIASIVAIVVIVLIMVIIYLILRYRRKKKMKKKLQYIKLLEE
Protein: PLSCR1 protein (Phospholipid scramblase 1, isoform CRA_f) (Q8WVK1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQVISKTQNTHKKQNCASSLLNQISK
Protein: Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (P58750)
Organism: Mus musculus (Mouse)
Function: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGVAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL
Protein: Secretin (P11384)
Organism: Rattus norvegicus (Rat)
Function: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (By similarity). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis. Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:19805236, ECO:0000269|PubMed:3047699}.
Interaction partners:
- Secretin receptor
- Pro-glucagon
- Pituitary adenylate cyclase-activating polypeptide
- Gastrin
- Somatostatin
- Cholecystokinin
- VIP peptides
- Somatoliberin
- Gastric inhibitory polypeptide
- Vasoactive intestinal polypeptide receptor 1
Sequence:
MEPLLPTPPLLLLLLLLLSSSFVLPAPPRTPRHSDGTFTSELSRLQDSARLQRLLQGLVGKRSEEDTENIPENSVARPKPLEDQLCLLWSNTQALQDWLLPRLSLDGSLSLWLPPGPRPAVDHSEWTETTRQPR
Protein: Orotate phosphoribosyltransferase 2 (OPRT 2) (OPRTase 2) (EC 2.4.2.10) (P30402)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Interaction partners:
- Dihydroorotate dehydrogenase
- Orotate phosphoribosyltransferase 1
- Orotidine 5'-phosphate decarboxylase
- Ribose-phosphate pyrophosphokinase 3
- Ribose-phosphate pyrophosphokinase 4
- Ribose-phosphate pyrophosphokinase 5
- Pyrimidine pathway regulatory protein 1
- Ribose-phosphate pyrophosphokinase 1
- Ribose-phosphate pyrophosphokinase 2
- Protein transport protein GOT1
Sequence:
MSASTTSLEEYQKTFLELGLECKALRFGSFKLNSGRQSPYFFNLSLFNSGKLLANLATAYATAIIQSELKFDVIFGPAYKGIPLAAIVCVKLAEIGGTKFQGIQYAFNRKKVKDHGEGGIIVGASLEDKRVLIIDDVMTAGTAINEAFEIISIAQGRVVGCIVALDRQEVIHESDPERTSATQSVSKRYNVPVLSIVSLTQVVQFMGNRLSPEQKSAIENYRKAYGI
Protein: Eukaryotic translation initiation factor 1A (eIF-1A) (Eukaryotic translation initiation factor 4C) (eIF-4C) (Liver regeneration-related protein LRRG048) (Q6VV72)
Organism: Rattus norvegicus (Rat)
Function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Eukaryotic translation initiation factor 2, subunit 2
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS19
- 40S ribosomal protein S15
- Eukaryotic translation initiation factor 2 subunit 1
- Small ribosomal subunit protein uS7
- Eukaryotic translation initiation factor 5
- Small ribosomal subunit protein uS2m
Sequence:
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
Protein: Ceramide kinase-like isoform 2 (G0XYF0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFRGRRRSRVGALEEAPPENPKAAAEPERVLLRGIFEIRRESCDVALGERALRWRRIQPELPAGGTRHDLLSKEESLELEDIFSVKLKRRCWAKHPGRDTLLGITLFICLKEQRNKLKDSTLDLINFSEDHCDIWFRQFKKILDGFTSRPKALKILLNPQSHRKESVHVYYEKVEPLLKLAGIETDVTRSTNALAHSLFGTPHVVTATMHIILGHIRSVDVCTFSSAGKLLCFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAIIKALAKLKPEDCKISFLLAGCSQNKQERKSQRSAESDCGGHWQTIQGQFLNISIMAMPCPCSMAPRGFTPDTRLHNGSMALRVVRNTTRSEFVKHLKRHSSVKNQFNFPFVETYIIEEVKIHPKSNSNGYSPQEEGGNHTTASEHGFPWNVDGDLMEAASEVHIRLHPRLIRLYGGSLEEMNDCKVACDCI
Protein: Cobalt import ATP-binding protein CbiO (EC 7.2.2.-) (Energy-coupling factor transporter ATP-binding protein CbiO) (ECF transporter A component CbiO) (O68106)
Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Function: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Cobalt transport protein CbiM
- Cobalt transport protein CbiQ
- Cobalt transport protein CbiN
- Nickel transport protein NikQ
- Fused nickel transport protein NikMN
- Nickel import ATP-binding protein NikO
- Energy-coupling factor transporter transmembrane protein BioN
- DUF4198 domain-containing protein
- Hemin ABC transporter, permease protein
- Cobalamin biosynthesis protein CbiG
Sequence:
MTPILAAEALTYAFPGGVKALDDLSLAVPQGESLAILGPNGAGKSTLLLHLNGTLRPQSGRVLLGGTATGHSRKDLTDWRRRVGLVLQDADDQLFAATVFEDVSFGPLNLGLSEAEARARVEEALAALSISDLRDRPTHMLSGGQKRRVAIAGAVAMRPEVLLLDEPTAGLDLAGTEQLLTLLHGLRAAGMTLVFSTHDVELAAALADRVALFRTGRVLAEGAAAAVLSDRATLAQGGLRPPLVIDLALSRARSRPFGPRSALPRTRDALAAQMAGWTRR
Protein: Histone-lysine N-methyltransferase EZ1 (EC 2.1.1.356) (Protein SET DOMAIN GROUP 718) (SET family protein 1) (OsSET1) (SET family protein 15) (OsSET15) (Q10MI4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (Probable). Involved in the regulation of flowering. Promotes flowering under short day (SD) conditions. Regulates the trimethylation on histone H3 'Lys-27' (H3K27me3) of the flowering regulator LF.
Subcellular location: Nucleus {ECO:0000269|PubMed:12815033}.
Interaction partners:
- Polycomb group protein FIE1
- Polycomb group protein FIE1
- Polycomb group protein EMF2B
- Probable lysine-specific demethylase SE14
- Polycomb group protein EMF2A
- Histone-binding protein MSI1
- Calmodulin-lysine N-methyltransferase
- Histone-lysine N-methyltransferase CLF
- Os01g0710000 protein
- Os07g0239000 protein
Sequence:
MASSSSKASDSSSQRPKRPDQGPSGKDAAGLVALHGKLAQLKRQVQSTRLAAIKERVEANRKALQVHTCALFDVAAAAEVASRGAEGGNALSRGAAEGHRRFVGWDSASGPGERELVHVQEENLVAGTLVLSSSGGSGASHRTVVQLVKLPVVDKIPPYTTWIFLDKNQRMADDQSVGRRRIYYDPIVNEALICSESDDDVPEPEEEKHVFTEGEDQLIWKATQDHGLSREVLNVLCQFVDATPSEIEERSEVLFEKYEKQSQSSYKTDLQLFLDKTMDVALDSFDNLFCRRCLVFDCRLHGCSQNLVFPSEKQPYGHELDENKRPCGDQCYLRRREVYQDTCNDDRNACTTYNMDSRSSSLKVSATILSESEDSNRDEDNIKSTSIVETSRSKITNSEYADKSVTPPPGDASETENVSPDMPLRTLGRRKISKHASKSNDHSPDKRQKIYSSPFPFAMSVLNKQSVPEIGETCPDSIESAVDQLPSLDDPNKKISTKDMCAGSTTNTTENTLRDNNNNLFISNKEHSISHWSALERDLYLKGIEIFGKNSCLIARNLLSGLKTCMEVASYMYNNGAAMAKRPLSGKSILGDFAEAEQGYMEQDLVARTRICRRKGRARKLKYTWKSAGHPTVRKRIGDGKQWYTQYNPCGCQQMCGKDCACVENGTCCEKYCGCSKSCKNRFRGCHCAKSQCRSRQCPCFAASRECDPDVCRNCWVSCGDGSLGEPLARGDGYQCGNMKLLLKQQQRILLGKSDVAGWGAFIKNPVNRNDYLGEYTGELISHREADKRGKIYDRANSSFLFDLNEQYVLDAYRKGDKLKFANHSSNPNCYAKVMLVAGDHRVGIYAKDRIEASEELFYDYRYGPDQAPAWARRPEGSKKDEASVSHHRAHKVAR
Protein: Protein SUE1, mitochondrial (Q06524)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for degradation of unstable forms of cytochrome c.
Subcellular location: Mitochondrion envelope {ECO:0000269|PubMed:15123691}.
Interaction partners:
- MIOREX complex component 6
Sequence:
MILLKRTKIRGVSVSFVSLQRRTHSRLVNPIRQQHQQITKQRSSKILKNAHFYDFRSLPKVPTTQYLEARELTRDILYSGYRPVMYPVKENPLFRDKKRKSLQTLLTMNEKTNAEAKTIDEKKHKNILFGERGTGGIMSGGVNGTWKYNPTVPNELLPFNWWSTSSMGMEYFPEWKNVPPYMMRKLKPFDKALQMRLTHKSKKKMK
Protein: ORF49 (E5LBX2)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MTSRRPLKDHLFNHLFRYHYPSWDQILQELDTLSVATLNPDCHVPALNVEKTLYLAKTIQILVQHRQSEPYLVPAARANLAYSLQQLYKLGNDKIRGVINGMLPLVDAGCIGFERELIKGLPRVLTLQYPHTAPLESEPPTADCTEWCLSHFVGASGRLRSEVRDILTTHNGTCAPSFEWMASVVKKFFLVETVIYEDFQDTDFNVQLNLCFFWTAVVQMYQRCIYEQKLVHIISTSLTLLKSTARSFFAWYDLYRPNLGSAALVKYTEHLIRALTPDCSDVELGELCSHLHHCKHALFSIQ
Protein: DDHD domain-containing protein (G5EED9)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- DAF-15
- LIM interaction domain-containing protein
- Putative diacylglycerol kinase K06A1.6
Sequence:
MLIKEYRILLPMTVQEYRIAQLYMIQKKSRLDSHGQDSGVEIISNKPYTDGPGGSGQYTFKIYHIGSRIPAWIRTVLPTNALEAHEESWNAYPVTKTRYSTPMMDRFSLEVETLYFDDHGQQENVFNLNEKDKSTRIIDYMDFVKDPISSHDYCAEEDPKLYRSETTNRGPLNDDWVAEHLKKGLPIMCAYKLCKVEFRYWGMQTRAERWIHDLALRNTMMRAHRQAWAWQDEWTGLTMNDIRKLEAEAALHLSKVMSVKENEDGHQDENDTDDDMDAGDAVSDDLYFDCTDTSPIPTQKPSIIRWSSELELEIQDDNSPPLTPHNGSTEVALLIMVFHGDFSPDNPADSKTTDTNTFSSTIETCVQRHYPQLRNRLHIVNVSCGHEMTQVVSKLSNISPSFGLLHPSLSLMLPSASHLYNEAVEGTIRRANETYNEFIASQPLFNGEVFVVGDCVGGIFLYEAMTRKCDSMTLLKRLSSNLSSRIIKEDQSPHQSMTDITITDTSSISSCPQQHNQSVRDHSSLQNGHASRRSARNYSAPPSASYVRKKISLVSVDSVSFGASRLSFQPSTVFLLGCPLGLTLMQRKLDGSEIDGLDSCQLFNLYYPLDPCGARIEPVLDGQLSCVPPYNVPKYQRYPLGDGKSQKFESTIDATQMWGSKRIDNLLYCPNSMVALPSSALPNILHASYWESCDVASFLLRQFVRGEENSVLTTLSSSMNNIPLNIDLPTMHWKRKRTRFKIANLSANHRANDILVTAGMDLTVIAKFCYGPMDLVALSREPVSVFVYPQRGDWYLHGVFDTDSHGRLTLQLAKTLPCGIHSVKIVVHGDRSYLDAFVAIVPHGTKCAVFSVDGSLTASVSVTGKDPRVRPGAVDVVRYWQEQGYLIIYLTARPDMQQRVVSAWLAQHNFPHALLFFNNSFSTEPLKQKSLHLRHIVDMGVHIHVAYGSGKDVNVYTSAGVDPEHVISVAGSRRRNCVQIESYSSHLAALNSGQCTLGKRIEDDGLTLQLHRNVQRTPSFTPRGGKFENEKDRR
Protein: A-kinase anchoring protein 10 (E7EMD6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL