wanglab/gogpt-training-data huggingface dataset:
Protein: Ent-copalyl diphosphate synthase AN1, chloroplastic (Ent-CPP synthase) (Ent-CPS) (EC 5.5.1.13) (Ent-kaurene synthase A) (Protein ANTHER EAR 1) (Q41771)
Organism: Zea mays (Maize)
Function: Involved in giberellin biosynthesis (Probable). Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate (Probable).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Kaurene synthase4
- Kaurene synthase3
- Geranylgeranyl diphosphate reductase, chloroplastic
- Geranylgeranyl diphosphate reductase, chloroplastic
- Ent-copalyl diphosphate synthase 2, chloroplastic
- Solanesyl diphosphate synthase 2 chloroplastic
- all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]
- Geranylgeranyl pyrophosphate synthase2
- all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]
- Geranylgeranyl pyrophosphate synthase3
Sequence:
MPYPHPYPWQSSRRRRRRRGRDGAPRQPQARRVVERAAAGPGHATTTQQPDNVSSAKVFQTSRVETESEIAKWPGKPQDLEDEHQAEEAELQPLIDQVRAMLRSMNDGDTSASAYDTAWVAMVPKVGGDGGAQPQFPATVRWIVDHQLPDGSWGDSALFSAYDRMINTLACVVALTKWSLEPARCEAGLSFLHENMWRLAEEEAESMPIGFEIAFPSLIQTARDLGVVDFPYGHPALQSIYANREVKLKRIPRDMMHRVPTSILHSLEGMPDLDWPRLLNLQSCDGSFLFSPSATAYALMQTGDKKCFEYIDRIVKKFNGGVPNVYPVDLFEHIWVVDRLERLGISRYFQREIEQCMDYVNRHWTEDGICWARKSNVKDVDDTAMAFRLLRLHGYNVSPSVFKNFEKDGEFFCFVGQSTQAVTGMYNLNRASQISFQGEDVLHRARVFSYEFLRQREEQGMIRDKWIVAKDLPGEVQYTLDFPWYASLPRVEARTYLDQYGGKDDVWIGKTLYRMPLVNNDTYLELAIRDFNHCQALHQLECNGLQTWYKDNCLDAFGVEPQDVLRSYFLAAACIFEPSRAAERLAWARTSMIANAISTHLRDISEDKKRLECFVHCLYEENDVSWLKRNPNDVILERALRRLINLLAQEALPIHEGQRFIHSLLSLAWTEWMLQKANKEENKYHKCSGIEPQYMVHDRQTYLLLVQVIEICAGRIGEAVSMINNKDNDWFIQLTCATCDSLNHRMLLSQDTMKNEARINWIEKEIELNMQELAQSLLLRCDEKTSNKKTKKTLWDVLRSLYYATHSPQHMIDRHVSRVIFEPV
Protein: C' protein (P04862)
Organism: Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))
Function: The different isoforms prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2. Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm. They inhibit IFN-gamma induced serine phosphorylation of STAT1. Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex (HMWC) formation and inhibition of transcription by IFN-gamma. May also have a role in preventing the cell to enter apoptosis. Modulate regulation of viral transcription and replication. Overexpression inhibits the viral RNA polymerase. The absence of all C', C, Y1 and Y2 proteins leads to viral delayed growth. Plays an important role in virion particles release. Modulates virion shape.
Subcellular location: [Isoform C' protein]: Host cytoplasm {ECO:0000269|PubMed:2171459, ECO:0000269|PubMed:3026113}. Note=Protein C' seems to localize around the Golgi. {ECO:0000269|PubMed:3026113}.; SUBCELLULAR LOCATION: [Isoform C protein]: Host cytoplasm {ECO:0000269|PubMed:2171459, ECO:0000269|PubMed:3026113}. Virion. Note=The C protein is found in virion at a ratio of approximately 40 molecules per virion, presumably associated with the nucleocapsid. {ECO:0000269|PubMed:2171459}.
Interaction partners:
Sequence:
MASATLTAWIKMPSFLKKILKLRGRRQEDESRSRMLSDSSMLSCRVNQLTSEGTEAGSTTPSTLPKDQALLIEPKVRAKEKSQHRRPKIIDQVRRVESLGEQASQRQKHMLETLINKIYTGPLGEELVQTLYLRIWAMEETPESLKILQMREDIRDQVLKMKTERWLRTLIRGEKTKLKDFQKRYEEVHPYLMKEKVEQVIMEEAWSLAAHIVQE
Protein: Auxin response factor 2A (SlARF2A) (Q2LAJ3)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs) (By similarity). Could act as transcriptional activator or repressor. Involved in the control of fruit ripening process. Regulates expression of a number of ripening regulators, transcription factors, and ethylene biosynthesis and signaling components. May act as a transcriptional repressor of auxin-responsive genes. Regulates vegetative growth, lateral root formation and flower organ senescence, possibly partially by regulating gene expression of auxin and ethylene response factor (ERF) genes. Plays a negative role in axillary shoot meristem formation.
Subcellular location: Nucleus {ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00326, ECO:0000255|RuleBase:RU004561, ECO:0000269|PubMed:26716451, ECO:0000269|PubMed:26959229}.
Interaction partners:
- Alpha-L-arabinofuranosidase/beta-D-xylosidase
- Auxin-responsive protein
Sequence:
MAASEVSIQGYSEPSDGSRPVSETGRSSSGVGIVDADTALYTELWRSCAGPLVTVPREGELVYYFPQGHIEQVEASTNQVADQQMPLYNLPSKILCRVVNVLLKAEPDTDEVYAQVTLMPEPNQDENAVKKEPMRPPPPRFHVHSFCKTLTASDTSTHGGFSVLRRHADECLPQLDMSRQPPTQELVAKDLHGNEWRFRHIFRGQPRRHLLQSGWSVFVSSKRLVAGDAFIFLRGENGELRVGVRRAMRQQGNAPSSVISSHSMHLGVLATAWHAIQTKTMFTVYYKPRTSPAEFIVPYDHYMESVKNNYSIGMRFKMRFEGEEAPEQRFTGTIVGIEDADPQRWLESKWRCLKVRWDENSSIPRPDRVSPWKIEPALSPPALNVPPVARPKRPRSSILPTSPDSSVLTREGSSRATADHSQASGFPRVLQGQELSTFRGGFAEINETDLSEKPMIWQTSVNDEKNDIHSASKRYLPDKWLPLGRPESSLTDLLSGFGSSHGFCLPSADQAAFGARLVKQQTQDQEKDFSLLGKPWSLLSSGLSLNLMDSGSKAPGIGGDTPYQMRGDARYSGYGEFSVLPGHRVANQQGSWIMPQPVSPYMQLSSHSREMMHKPSVVKQPEAVKPKEGNYKLFGIPLTSNVCTDAVMMRKSSLIDPASDMNIGIHPHQSLATDSDQRSEQSKGSKVDDGVAANDHDKQFHTFHLAARDKDGKGHSSSTRSCTKVHKQGTALGRSVDLAKFNNYDELIAELDQLFDFNGELKARSKSWLVVYTDDEGDMMLVGDDPWQEFCGMVRKIFIYTKEEVQRMNPGTLNSKGEDTSSVAEGSDAKEVKNLQLPSESGQAES
Protein: Orphan antitoxin YefM (P40819)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Putative antitoxin component of a toxin-antitoxin (TA) system; its cognate toxin is unknown.
Interaction partners:
- DNA topoisomerase 4 subunit B
- Transport protein
- tRNA
- Cytoplasmic protein
- Homology to death-on-curing protein of phage P1
- Cytoplasmic protein
- ATP-dependent Clp protease proteolytic subunit
- Endoribonuclease SymE
Sequence:
MFMRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK
Protein: Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) (Q8BUL6)
Organism: Mus musculus (Mouse)
Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9HB21}. Cell membrane {ECO:0000250|UniProtKB:Q9HB21}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HB21}. Nucleus {ECO:0000250|UniProtKB:Q9HB21}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250|UniProtKB:Q9HB21}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 13
Sequence:
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPASDSLSRQGDCGKKQVSYRTDIVGGVPIITPTQKEEVNECGESLDRNNLKRSQSHLPYFAPKPPSDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSSSSMRQARRLSNPCIQRSIPAGLQNPNSLSVLPGPQPPPHIPQPLAATLWSQAVPWRSEEFTNLLPRSSQGTSRSRLSLQESQLPK
Protein: Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) (Q7YW31)
Organism: Octopus vulgaris (Common octopus)
Function: Acts as a receptor for cephalotocin.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRYITTHPNEISTQIWNNFSSTEIWSNFSAAKNETQPIRRNQDLANAEVITLAVVIIITVIGNSIVLITLFQRRKKLTRMHLFILHLSVTDLFVAFFNNLPQMIWDITFLFLGTDLLCRLVTYLQSVAMYASSYVLVATAIDRYFAICHPLSSHKWTTARVHVMVFIAWMLSFLFSTPQLFIWSMQFSNIGLTCQATFDPEWTLKFYITWLTVAIWILPTIALTLFYGMMCFAVWKRGRSTLGSSRTRNRSFLTNRVSTRIGQSHLARGFSEEDMEGQSVNYNRGISRAKVRSVALTLSVVACCFICWSPFFVCQMWAAWDENAPYSGAIYTILLLLSSLNSCTNPWIYMIFSVFQHRAKTSRFVNDEETTSVTVLSSRNDIRLMSMKKKLEQTARN
Protein: Probable cysteine desulfurase, mitochondrial (EC 2.8.1.7) (O74351)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P25374}.
Interaction partners:
- Iron sulfur cluster assembly protein 1, mitochondrial
- Protein isd11
- Frataxin homolog, mitochondrial
- Probable 3-mercaptopyruvate sulfurtransferase
- Adenylyltransferase and sulfurtransferase uba4
- NifU-like protein C1709.19c
- Cytosolic Fe-S cluster assembly factor nbp35
- Monothiol glutaredoxin-5
- Iron-sulfur cluster assembly factor IBA57
- Lipoyl synthase, mitochondrial
Sequence:
MSKMGSLMLSRARCLLELRSALFFVKRESQDINNVRQSLGVYGRSFMTSSRMDKPSMSNKPREQMYGLGNMTAVQEPIPENSLKTVTLDQAQTAASTVTGLHPIYMDFQATSPLDYRVLDSMLPFFTGIYGNPHSRTHAYGWEAEKAVENARQEIASVINADPREIIFTSGATESNNAILKGVARFYKSRKKHLVSVQTEHKCVLDSLRALQEEGFEVTFLPVQTNGLINLDELRDAIRPDTVCVSVMAVNNEIGVCQPLEEIGKICRQKKVFFHSDAAQGYGKIDIDVNRMNIDLMSISAHKIYGPKGIGAAYVRRRPRVRLEPLISGGGQERGLRSGTLAPSQVVGFGTAARICKEEMKYDYAHISKLSQRLIDGLLAIPYTSLNGDPKSRYPGCVNISFNYVEGESLLMGLKNIALSSGSACTSASLEPSYVLRAIGQSDENAHSSIRFGIGRFTTEAEIDYAIENVSRQVSFLRNMSPLWDLVQEGVDLSTIEWSQH
Protein: Uncharacterized protein (Q54RN4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MFDNNSSNNTITGGGNFNNSSSININNSNNNNNNNNDSNELLPLTEYNDYSRSPTPPTVLNNSSFSNNFNINNNNNNNINNNNNNSIGYKKGDDSFGSFLNFNNNNNSHDNNNNNNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINSNSNFNNNNSETIKRSKSTPFLNLMNSPNMSSTTTSTVQNNNNNNNNNNGNSSNKIPNRIFQFYLQQQYQQQPINNNNNNNNNNNNNNNNNNDNDNDNNIGSPNLSPQTPTQYPNNLASLYGNPYSPNSNNNNNNNNNTSNTNNAITTTTNATATSTTAATTTNSNNNNNNNNNSNNNNNNNSINNNNNNNINNNISQQQKEDFINQINFILNEVDSLKKKVRELEEEQRSEGRNAWGLKYARRVLITSNFLLGIWVSISRILMYIGKQKKSRLLHVVVPSLGQKESRNHISLLLLEAISNAARKSWIFFISSFLLSRNTAWKRQTGLFFCTIYSLYLAFFPQYLPWTNYFNIFASLLYVTAAWSTARSGSSFREIFNLL
Protein: Toxin CcdB (Cytotoxic protein CcdB) (LynB) (Protein G) (Protein LetD) (P62554)
Organism: Escherichia coli (strain K12)
Function: Toxic component of a type II toxin-antitoxin (TA) system, functioning in plasmid maintainence. Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Half-life of over 2 hours. Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss. Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA. DNA breakage requires hydrolyzable ATP. Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Also acts to inhibit partitioning of the chromosomal DNA. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA.
Interaction partners:
Sequence:
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEVADLSHRENDIKNAINLMFWGI
Protein: Ubiquitin-related modifier 1 homolog (Q583L0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03048, ECO:0000256|RuleBase:RU361182}.
Interaction partners:
- Adenylyltransferase and sulfurtransferase MOCS3 homolog
- GRIP domain-containing protein
- Guanylate kinase, putative
- Guanylate kinase, putative
Sequence:
MSNHNHITVQFAGGCELLFAKQTSLQLDGVVPTGTNLNGLVQLLKTNYVKERPDLLVDQTGQTLRPGILVLVNSCDAEVVGGMDYVLNDGDTVEFISTLHGG
Protein: histone deacetylase (EC 3.5.1.98) (A0A8I6AB01)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSPVQPDGVAGREQLLAQQRMHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDTKDDFPLRKTESSVSSSSPGSGPSSPNNGPAGNVTENEASVLPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLSASNSLKDKQKCETQMLRQGVPLPGQYGSGIAASSSHAHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMEERATSKDSGTGKDSSACVEDTLGQVGAVKVKEEPVDSDEDAQMQEMECGEQAAFMQQVIGKDLAPGFVIKVII
Protein: DNA repair protein RecO (Recombination protein O) (P9WHI5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in DNA repair and RecF pathway recombination.
Interaction partners:
- Recombination protein RecR
- Decaprenyl diphosphate synthase
- Uncharacterized protein
- RecBCD enzyme subunit RecB
- DNA repair protein RecN
- Protein RecA
- Putative amidase AmiA2
- Holliday junction branch migration complex subunit RuvB
- PhoH-like protein
- Adenine DNA glycosylase
Sequence:
MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIEVQLHPGRNLDIVTQVVSVDAFATDIVADYGRYTCGCAILETAERLAGEERAPAPALHRLTVGALRAVADGQRPRDLLLDAYLLRAMGIAGWAPALTECARCATPGPHRAFHIATGGSVCAHCRPAGSTTPPLGVVDLMSALYDGDWEAAEAAPQSARSHVSGLVAAHLQWHLERQLKTLPLVERFYQADRSVAERRAALIGQDIAGG
Protein: Probable glucoamylase (EC 3.2.1.3) (1,4-alpha-D-glucan glucohydrolase) (Glucan 1,4-alpha-glucosidase) (Meiotic expression up-regulated protein 17) (O60087)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Alpha-amylase mde5
- Uncharacterized glycosyl hydrolase C27E2.01
- Uncharacterized glycosyl hydrolase C11E10.09c
- Alpha-amylase 4
- Alpha-amylase 2
- Alpha-amylase 3
- Alpha-amylase 1
- Uncharacterized family 31 glucosidase C1039.11c
- Uncharacterized family 31 glucosidase C30D11.01c
- Alpha-glucosidase
Sequence:
MRTYWLFLLLGGVVSAESLLSPNKRSKEASMDEWTDQQKGIAMGHMLNNIGDSGMHAKDINPGCIIASPSTDSPDYYYQWVRDSALTIMTILDRFFEGDKGLEPIIVKYMDEMVRLQKVPNPSGDFYAGGLGEPKFNVDGTSYDGDWGRPQNDSPALRAIAFIKYMNYLFENGKEVHEVTVWIEAVLADLDYTANHWTEASFDLWEEIKDVHYFTLAVQKRAMQDGTAFAKRIGAPDQAALYQRTIEPIDLKLGEFWDPGMGVIKGYKGRVDRSGLDCSTLLASLYSNEFDMHILPTLLKLQETMTRDYPVNQGWKQAMGRYPEDVYDGVSKSIGNPWFICTSSAAEIIYKAIAYYDNKGLPELTEYNIHFFMKFAEFGDPYNWSVIRKNMHTYADNFLKAVAEFQHPNGSMSEQFSRDDGHQKGARDLTWSYSSLLNAIYRREAIKGSV
Protein: Possible membrane acyltransferase (O33362)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- GDSL lipase Rv0518
- Probable conserved transmembrane protein alanine and leucine rich
- Uncharacterized protein Rv0048c
Sequence:
MAGGMDQPPGQPRRRTRQQSSDGKNGVRAAEITGEIRALTGLRIVAAVWVVLFHFRPMLGDASPGFRDALAPVLDCGAQGVDLFFILSGFVLTWNYLDRMGRSWSVRANLHFLWLRLARVWPVYLVTLHLAAVWVIFTLHVGHVPSPEAGQLTAISYVRQILLVQLWFQPYFDGSSWDGPAWSISAEWLAYLLFGLLILVIFRMKHATRARGLMWLAFAASLPPVVLLLASGQFYTPWSWLPRIVTQFAAGALACAAVRRLRPTDRARRIAGYLSVLVGVAIVGILYLLHAHPLAGVEDSGGVVDVLFVPLVISLAIGVGSLPALLSTRLMVFGGQISFCLYMVHELVHTAWGWAVQQYELALQDQPWKWNVVGLLAIALGAAILLYHFVEEPGRRWMRRMVDVKAASARSEPGEPVGSTRYQIDDALEGVSARAV
Protein: pH-response regulator protein palH/RIM21 (Regulator of IME2 protein 21) (P48565)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity). Required for growth at alkaline pH.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- pH-response regulator protein palI/RIM9
- pH-response regulator protein palF/RIM8
- Protein DFG16
- pH-response transcription factor pacC/RIM101
- pH-response regulator protein palA/RIM20
- Calpain-like protease 1
- Vacuolar-sorting protein SNF7
- Uncharacterized protein YGR122W
- Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
Sequence:
MNLWRHSPEELAAYNSCHPMKLGSGVLIQLPLYDNSAVYAEDITFRSFCCERVPVYVSTVLRNSSPYRYLDEVINDWQKFIQVSDYVGGSAEYAIYAVILSITSNFVITVFLTVICCINISGRAYKRILQLLRIASLLASLNLTIFITKVLRRLEKEHNVYGVVRAHSIMHIFSDDMTFVVLDFLATLMFQFCQVGIVIRLFQRAQEKRIIFFIGVILTITANILWVIPPFANHTTKHRNDWQILRPFVYLFRIAIATSYASIVIYHIWQKKKLWFKFNQMGLLTLLTILVVLLLPGFFLADVSNLWISELGEVFNTTCYVTSTVITWEWLDRLNVLERKEEAQSILGRPIFEEEQQDYRFAKYALRVQNALTRRESQDASTDRHDTSSNSEVCDLQTISRYDPEDQISVGRSIDRMHFNDRGTYKDVALKKLGYARDKILYFTDQIVQKSVGHNNSSSSKNEKTKQRKAMVRKRLGLDKPGIYIYSTKDVVFNSDEDDDENAEDEDDDEYEVGSEGNNNSSATFTSDHIGHI
Protein: Direct IAP-binding protein with low pI (F7F5S4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MLRHFRRVRPASVRRGMAALRSWMTRSVTFLFRYGQRFPVSANSKKRCFSELIRPWHKTMLTGFGVTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGRSGLYNRQESHPVGEVAGAGGAPALPEGGNQAGRSADTRAAPENTGSER
Protein: Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) (P31637)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (By similarity). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity). Has very low affinity for sugars such as L-fucose and L-xylose, with an affinity about three orders of magnitude lower than myo-inositol.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000305|PubMed:1372904}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNQ1 at the apical membrane of choroid plexus epithelium. {ECO:0000250|UniProtKB:Q9JKZ2}.
Interaction partners:
Sequence:
MRAVLETADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIVGALTLMIISMMEIGGFEEVKRRYMLASPNVTSILLTYNLSNTNSCNVHPKKDALKMLRNPTDEDVPWPGFVLGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFADDIACINPEHCMQVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRRSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLTLAFAYRAPECDQPDNRPGFIKDIHYMYVATALFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKSLVVKESCSPKDEPYKMQEKSILRCSENSEATNHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETEDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEEPPQVKLILNIGLFAVCSLGIFMFVYFSL
Protein: Centrosomal and chromosomal factor (CCF) (Chromocentrosomin) (P41046)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential protein required for proper condensation of mitotic chromosomes and progression through mitosis. Binds to specific polytene chromosome sites, many of which are shared with the posterior sex combs (Psc) protein. Involved in maintaining Abd-B repression outside its normal expression domain.
Subcellular location: Nucleus {ECO:0000269|PubMed:9463384}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9463384}. Chromosome {ECO:0000269|PubMed:12771214, ECO:0000269|PubMed:18286205}.
Interaction partners:
- Cyclin G
- Histone-lysine N-methyltransferase E
- Polycomb group protein Asx
- Polycomb group protein Pc
- Polycomb protein esc
- Large ribosomal subunit protein uL11
- Polyhomeotic-proximal chromatin protein
- Longitudinals lacking protein-like
- Transcription activator GAGA
Sequence:
MTMAACYANYDMSSLSHGMSALSALQQQQQQQQQQHSQTQQQHHHQQQQQHMYHAAVAAHQQQLLQQQQQQQHHRHHHQPANTSSSSNSRHSHAAATQTQVAAAVANSRQQQQQQQQQQQQQQQQQTASSNSNAAPAPSPQKDYSIPLHVDCSVEYELPNQPKPPAGQRVEPLLMIHPCYFRKMESQRRSPFVNNMHATARAVSSSSLSSGAALGGGGSGAAVATAPSSSAARRGARAATSAQQQQQQQQRYQQQQQQLRQQHQQMSQMSQQAHYPQQQSSLVRQHQQQQQQQQQQQRASSNQSQRQSQSQSQSQSHAANSAAAAAAQASIAAAAAGQWDQLAALAARTALTPHHMLHPHSHYAAKGSGGGAGGGKRDAMISGSYGQTAVASGKLQQSQVQQQQPQQQQQHCLPPPPWDATSMLMDRSPMATVPSNYQAGPDTNPMRLYSATPTAGAASGGSASVGGGGAVSGAGATGAVNTATDKLSGKYRQYLRSQRMHPYAAAASLNLAAAAAAAGQTSFVPFSSAATAVAATPTFQHLPQISCYNV
Protein: BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) (O35153)
Organism: Mus musculus (Mouse)
Function: Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Note=Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks. {ECO:0000250}.
Interaction partners:
- Golgi SNAP receptor complex member 1
- Syntaxin-5
- Synaptobrevin homolog YKT6
- Golgi SNAP receptor complex member 2
- General vesicular transport factor p115
- Vesicle-trafficking protein SEC22b
- BET1 homolog
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-6
- Vesicle-associated membrane protein 4
Sequence:
MADWTRAQSSGAVEDILDRENKRMADSLASKVTRLKSLALDIDRDTEDQNRYLDGMDSDFTSVTGLLTGSVKRFSTMARSGRDNRKLLCGMAVVLIVAFFILSYLLSRTRT
Protein: KIB1-4 beta-propeller domain-containing protein (Q9FIU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin-like superfamily protein
- COP9 signalosome complex subunit 3
- Prefoldin subunit 2
- Putative F-box protein At5g55150
- Protein DETOXIFICATION 3
- Putative F-box protein At4g22180
- Probable F-box protein At4g22030
- F-box protein At2g16300
- Prefoldin subunit 3
- Protein DETOXIFICATION 4
Sequence:
MSLLLSRLSRLRLGKPASVRSSVLILSNGFSSSSLQTPPCSIICANPCGAGLGKLVILNANESDYTDLEKKVPMELVDSDPMVTIGASHGWVATLKEDGILRLQDDLNPYASDTNPKRISLPPLVTLPRCQTQIVTNVSMSLPSPEDEDCVVAVKFLGPQLSFCRPAKSNSEWTNIKIANPSFFSSRVMFSKKDEMFRIPGSGGHLIGSWDLRTEDHNPKIQRLRFRNLPELPRAKRELLDSCYRSEHLVESQSTGELFLVKRYKKATTRDTVKMKTQGVMVFKLDEKGNAVYTQDIGDLCIFLSKSEPFCSSSSRFPNYVDIYDVDEVAFACLEYDDPITGVTSTNRAPYHIPPQNID
Protein: L-gamma-glutamyl-L-propargylglycine hydroxylase (EC 1.14.11.-) (F8JJ27)
Organism: Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) (Streptomyces cattleya)
Function: Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes the hydroxylation of the dipeptide L-gamma-glutamyl-L-propargylglycine, leading to L-gamma-glutamyl-L-beta-ethynylserine. Cannot use L-propargylglycine as substrate.
Interaction partners:
Sequence:
MSGTTHHHATFPAVEAAAFTRRHLDDLAAGLLGTVRVPGFFGRPALDTMLTSLHRVPVVSFDLDRMHHPMARFGTALNDYRTPELALDADRYWHDADTARRQWAGIGMTPDPLELALDALGRAWGVRPAPATIGGRPAFVGMLREVNDGTFIHYDDINREYRGGLFDQKIVAQLAFNAWLAAPREGGTTTVWRHRWEPADENRRHGYGFQPTAVADDPYVTVAPAAGDALLFNANNYHVVHPGAPGQRRIALACFLGVTAGGELVVWS