wanglab/gogpt-training-data huggingface dataset:
Protein: UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (Protein EnvA) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase) (P0A725)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
Interaction partners:
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- UDP-3-O-
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Cell division protein FtsZ
- Lipid-A-disaccharide synthase
- Tetraacyldisaccharide 4'-kinase
- 3-deoxy-D-manno-octulosonic acid transferase
- Lipid A biosynthesis lauroyltransferase
- Cell division protein FtsA
- 2-dehydro-3-deoxyphosphooctonate aldolase
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
Protein: Frizzled class receptor 10 (Frizzled homolog 10) (Frizzled protein) (Frizzled-10 precursor) (Fzd10 protein) (Q9W6E3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Low density lipoprotein receptor-related protein 5
- Tyrosine-protein kinase RYK
- Protein Wnt-1
- Norrin cystine knot growth factor NDP.
- E3 ubiquitin-protein ligase znrf3
- Protein Wnt-5b
- Protein Wnt
- Protein Wnt-11
- Glypican 4
- Low density lipoprotein receptor-related protein 6.
Sequence:
MFAAGVGLSLGLLCFAGFCSAISSIDPDRPGEGRCQEIAIPLCKDIGYNLTVMPNLMGHEDQNEAAIKLHEFAPLIEFGCHSHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARQKCSPIMEQFNFHWPESLDCSRLPNKNDPNYLCMEAPNNGTDEPPKGSHTQSPDSRPPRPGNSQELPIKERVGKTTCSNPGKFHYVQKSESCAPKCYSNVDVYWSQGDKRFSMVWIAIWSILCFISSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYSVGFLVRLFVGVENVACDRDTGVQYIIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAIKTIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLLSGFVALFHIRKVMKTEGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKILAGEQKCADDGKSGEECVMKSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVFSRKLKKKTRRKAACVFTGSGPYLKPHPALKGHKTKYEPAGPPATCV
Protein: GILT-like protein F37H8.5 (O17861)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Protein kinase domain-containing protein
- Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
- Apple domain-containing protein
- Serpentine Receptor, class T
- Protein yippee-like
- Large ribosomal subunit protein mL44
- SAM domain-containing protein
- C3H1-type domain-containing protein
- Protein roller-3
Sequence:
MDTTCRCLLTPTIQPVLLKMLYRLVAAILLLGAVQATINCAAIPTSLWCSNKDLEAKCGFASFCDKHRAATHNQKINITVLIEALCPDCQNFLTKQLYPIVFKNFANYVNIELVPFGNAKVLEDGTIKCQHGEEECSINKFEGCFIDSMQDQSPLPTLSCIEESLQKKVEFADAVQQCFEKLQIGGDIQRLTQSCLVSKLGADLQNKAAAATANVWPEQHKFVPWVIINGVSLTSFQGFQNQLPTLLCEWYSGDKAIPYCEAALKLKYKKASIRSFF
Protein: Mite allergen Blo t 5 (allergen Blo t 5) (O96870)
Organism: Blomia tropicalis (Mite)
Interaction partners:
Sequence:
MKFAIVLIACFAASVLAQEHKPKKDDFRNEFDHLLIEQANHAIEKGEHQLLYLQHQLDELNENKSKELQEKIIRELDVVCAMIEGAQGALERELKRTDLNILERFNYEEAQTLSKILLKDLKETEQKVKDIQTQ
Protein: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (P9WFV9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00022}.
Interaction partners:
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein uL13
- Arginine--tRNA ligase
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein uL14
Sequence:
MTATETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLDWDEGPEVGGPYGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVEARHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQPVVRLRMPDDDLAWNDLVRGPVTFAAGSVPDFALTRASGDPLYTLVNPCDDALMKITHVLRGEDLLPSTPRQLALHQALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDHDLFGLDEMVAAFDVADVNSSPARFDQKKADALNAEHIRMLDVGDFTVRLRDHLDTHGHHIALDEAAFAAAAELVQTRIVVLGDAWELLKFFNDDQYVIDPKAAAKELGPDGAAVLDAALAALTSVTDWTAPLIEAALKDALIEGLALKPRKAFSPIRVAATGTTVSPPLFESLELLGRDRSMQRLRAARQLVGHA
Protein: Photosystem II 5 kDa protein, chloroplastic (PSII-T) (Nuclear encoded psbT) (PsbTn) (Q39195)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be a component of the oxygen-evolving complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}. Note=Associated with the photosystem II complex. {ECO:0000250}.
Interaction partners:
- Photosystem II reaction center W protein, chloroplastic
- Expressed protein
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein H
- Photosystem II CP47 reaction center protein
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Photosystem II D2 protein
- Oxygen-evolving enhancer protein 3-1, chloroplastic
- Chlorophyll a-b binding protein CP26, chloroplastic
- Chlorophyll a-b binding protein
Sequence:
MASMTMTATFFPAVAKVPSATGGRRLSVVRASTSDNTPSLEVKEQSSTTMRRDLMFTAAAAAVCSLAKVAMAEEEEPKRGTEAAKKKYAQVCVTMPTAKICRY
Protein: Trailer hitch, isoform E (M9PFB2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYILFRGSDIKDIRVVNNHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVPSQQPPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFGNLGGPNLANMVGNAGGSLAPGSGAPGSGPFMHIGGNQQQPKPQQQKQPNMLAGASRSTTPISLIVSPTAELTQQQQLHQQQNAGQGGNGRDAGHKRQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSGRQMDNNYSNNYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMMNMRNRGMGSRGPMRPNQGYRPQSANNQNKPRNKIKFEGDFDFEQANNKFEELRSQLAKLKVAEDGAPKPATNATAATATATNEQLNGETDKKDDSGNETGAGEHEPEEDDVAVCYDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSSTRRGSYRGRNQYYNNNGNGGINSGYGGAPGYNRNNYRMGGGGGNFRNRSNNRNNGGGRGGNGMPNITNGNTAAALKAANNAAGHGSNATDSSAPNATTATTKSTSLLPEQTQQVAAVSQ
Protein: Protein SRC2 homolog (AtSRC2) (O04023)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an activator of the calcium-dependent activation of RBOHF that mediates reactive oxygen species (ROS) production and may play a role in cold responses.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16227454}; Single-pass type II membrane protein {ECO:0000255}. Protein storage vacuole membrane {ECO:0000269|PubMed:16227454}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane {ECO:0000305|PubMed:23872431}; Single-pass type II membrane protein {ECO:0000255}. Note=Binds to C-terminal sequence of alpha-TIP and moves from the ER to vacuoles. Movement is accompanied by membrane internalization, and SRC2 is present in crystalloid-like structures within protein storage vacuoles (PSVs) in mature seeds. {ECO:0000269|PubMed:16227454}.
Interaction partners:
- Respiratory burst oxidase homolog protein F
- At2g18210
- Pre-mRNA-processing factor 17
- Transducin/WD40 repeat-like superfamily protein
- Serrate RNA effector molecule
- At2g29210/F16P2.41
- Protein STABILIZED1
- Large ribosomal subunit protein uL11z
- COX assembly mitochondrial protein
- Pre-mRNA-splicing factor
Sequence:
MECRSLDLTIISAEDLKDVQLIGKQDLYAVVSINGDARTKQKTKVDKDCGTKPKWKHQMKLTVDDAAARDNRLTLVFEIVADRPIAGDKPVGEVSVPVKELLDQNKGDEEKTVTYAVRLPNGKAKGSLKFSFKFGEKYTYGSSSGPHAPVPSAMDHKTMDQPVTAYPPGHGAPSAYPAPPAGPSSGYPPQGHDDKHDGVYGYPQQAGYPAGTGGYPPPGAYPQQGGYPGYPPQQQGGYPGYPPQGPYGYPQQGYPPQGPYGYPQQQAHGKPQKPKKHGKAGAGMGLGLGLGAGLLGGLLVGEAVSDIADMGDMGDMGDMGGFDF
Protein: 5', 3'-nucleotidase, cytosolic (J3KSX6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADKVASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKEETPSWEHILFTCCHNRHLVLPPTRRRLLSWSDNWREILDSKRGAAQRE
Protein: Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) (Q29RB1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for normal Golgi function. Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9H9E3}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H9E3}. Note=Mosty cytosolic, with about 5% membrane-bound. {ECO:0000250|UniProtKB:Q9H9E3}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 6
- Component of oligomeric golgi complex 3.
- Component of oligomeric golgi complex 2.
- Component of oligomeric golgi complex 1.
- Conserved oligomeric Golgi complex subunit 8
- Component of oligomeric golgi complex 5.
- Component of oligomeric golgi complex 7.
- Sec1 family domain-containing 1
- Syntaxin 16
- Synaptobrevin homolog YKT6
Sequence:
MEEAASPARRRGGPAGVSAVQTDTIEALTELEDLERVYAQLCAEEAEVQVELDALVGQQNNIETKMLSLQRMGPNLQLIEGDAVQLSGMINFTCSLAENVSSKVRQLDLTKKRLYQAIQRADDILDLKFCTDGVQTALRNQDYEQAAAHIHRYLSLDQSVIELSKQGGEGSAVEASLALLQEAERNLKTLVTTRLEEAVATGDLPQVERFFKILPLLGLHEQGLARFAQYLCSQLASKAEENLILAVGSDLGERRAPVIFADTLTLLLEGIARIVETHQPIVETYYGPGRLHTLLAHLQKECDKQAQKIVDKFIQQRDYNNKFQVVQSNMMRGMTTDKIEPRDLDPVLCEVTLMNSRAELYFRFLRRRIVADFEVADAMADEAVIQEHQQSLEQLLKNCQLSRTMQELIGYYIPMEEYYMRESVNKAVAMDTAEVGQLSSSVVDDVFYIVKKCISRALTSSSSDCVCAMINHATSVLETDFREVLVCKLRAGYPVSALQDLQRGVSSAVSLMQSSLQQGKITNLTQTLGIESQEQAKSAYLVTLNNVEVCSENISTLKKNLESDCAKLFSQGASSDHAKEKIDSCLSDLVNTSSKFKDLLQEGLQELNNTAIRPQVKPWISSFLSVSHNIEEEEFSEYEANDPFVQQLIVQLEQLMAEFKVGLSPVIYDTLTSLMTSLIAMEMEKTVFKCTFSRLGGLQFDKELRALVAYLSSVTSWTIRDKFARLTQMATILNLERVSEILDYWGPNSGPLTWRLTPAEVRQVLALRVDFRSEDIKRLRL
Protein: Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (Zinc finger transcription factor homolog CPG20) (O08876)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:20070857}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
Sequence:
MLNFGASLQQASEGKMELISEKSKEGAHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEEDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTAPAPPTGHFRSLSDAAKPPSIAPFKEEEKSPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHINVEATRKNIPCAAVSPNRPKPEPSTAANGAEKAGTAPYDFAVPSSETVICRSSQPAPTSPVQKSVLMSSPTVSTGGVPPLPVICQMVPLPANNSLVTTVVPSSPPSQPPAVCSPVLFMGTQVPKGTVMFVVPQPVVQSPKPPVVSPNGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPATASAQ
Protein: Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (P21139)
Organism: Rattus norvegicus (Rat)
Function: Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NTJ4}.
Interaction partners:
- Alpha-mannosidase
- Alpha-mannosidase
- Cytosolic endo-beta-N-acetylglucosaminidase
- alpha-1,2-Mannosidase
Sequence:
MAAAPFLKHWRTTFERVEKFVSPIYFTDCNLRGRLFGDSCPVTLSSFLTPERLPYEKAVQQNFSPAQVGDSFGPTWWTCWFRVELVIPEVWVGKEVHLCWESDGESLVWRDGEPVQGLTKEGEKTSYVLSERLHAADPRSLTLYVEVACNGLLGAGKGSMIAAPDPEKMFQLSQAKLAVFHRDVHNLLVDLELLLGVAKGLGEDNQRSFQALYTANQMVNICDPAQPETYPAAEALASKFFGQRGGESQHTIHATGHCHIDTAWLWPFKETVRKCARSWSTAVKLMERNTEFTFACSQAQQLEWVKNQYPGLYAQLQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKRFLTQKLSWNLVNSFPHHTFFWEGLDGSQVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGRTNHSGFLFGFGDGGGGPTQTMLDRLKRLGNTDGQPRVQLSSPGQLFTALERDSGQLCTWVGELFLELHNGTYTTHAQLKKGNRECEQILHDVELLSSLALARSAQFLYPAVQLQRLWRLLLLNQFHDVVTGSCIQLVAEDAMNYYEDIRSHGNTLLSAAAAALCAGEPGPKGLRHYQHTALEAHRSVGTTQGLVGLTRLALVTVPSIGYAPAPTPTSLQPLLPQQPVFVMQETDGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGALGNQFVLFDDVPLYWDAWDVMDYHLETRKPVRGQAGTLAVGAEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFHTEVHWHETHKFLKVEFPARVRSPQATYEIQFGHLQEADPQQHSWDWARYEVWAHRWIDLSECDFGLALLNNCKYGTSVRGNVLSLSLLRAPKAPDVTADMGRHEFTYALMPHKGSFQEAGVIQAAYNLNFPLLALPAPGPAPDTTWSAFSVSSPAVVLETIKQAEKSHQHRTLVLRLYEAHGSHVDCWLHTSLPVQEATLCDLLEQRDPTGHLSLQDNRLKLTFSPFQVRSLLLVLQPPAN
Protein: Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) (Q8N1F8)
Organism: Homo sapiens (Human)
Function: May regulate STK11/LKB1 function by controlling its subcellular localization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11741830}. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.
Interaction partners:
- Serine/threonine-protein kinase STK11
- Mothers against decapentaplegic homolog 4
- Zinc finger and BTB domain-containing protein 48
- STE20-related kinase adapter protein alpha
Sequence:
MTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCGSDHVVLLAVSRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTRDHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLVVVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVLLPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFYLRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVRVREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWEELFSIGLRTVIQEALALDR
Protein: Lipase 4 (EC 3.1.1.3) (Q9P8W1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Secreted {ECO:0000269|PubMed:11131027}.
Interaction partners:
Sequence:
MLFLLFLLVAPIYAGLILPTKPSNDPFYNAPAGFEKAAVGEILQSRKTPKPITGVFVPVKIQNSWQLLVRSEDSFGNPNVIVTTVMEPFNADPSKLASYQVFEDSAKADCAPSYALQFGSDVTTIATQVETYLLAPLLDQGYYVVSPDYEGPKSTFTVGKQSGQAVLNSIRAALKSGKITNLAEDAKVVMWGYSGGSLASGWAAALQPNYAPELGGNLLGAALGGFVTNITATAEATDGTVFAGIMANALGGVANEYPEFKQILQNDTDKQSVFDQFDNHCLADGVINYIGKHFLSGTNKIFKSGWNILKNPTISKIVEDNGLVYQKQLVPKIPILIYHGAIDQIVPIVNVKKTYQNWCDAGIASLEFSEDATNGHITETIVGAPVALTWIINRFNGKQTVSGCQHVKRTSNFEYPNIPPSILNYFKAALNILIQKGLGPDIQKDQVNPDGLKKIPILV
Protein: Single-stranded DNA-binding protein DdrB (DNA damage response protein B) (Q1J1N6)
Organism: Deinococcus geothermalis (strain DSM 11300 / CIP 105573 / AG-3a)
Function: ssDNA-binding protein that probably contributes to the ionizing radiation resistance of D.geothermalis. Plays a role in DNA repair and genome reconstitution, in a RecA-independent process, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation (Probable). Binds single-stranded DNA but not duplex DNA.
Interaction partners:
Sequence:
MLHIEFITDLGAKVTVDVESADKLLDVQRQYGRLGWTSGEVPVGGYQFPLENEPDFDWSLIGARKWTNPEGEEMILHRGHAYRRRELEAVDSRKMKLPAAVKYSRGAKNTDPEHVREKADGEFEYVTLAIFRGGKRQERYAVPGSNRPQAGAPARSAATRAQGARPGAVAVQDEETPF
Protein: Zinc finger protein 404 (Q494X3)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MARVPLTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLDFNFTTESNKLSSEKRNYEVNAYHQETWKRNKTFNLMRFIFRTDPQYTIEFGRQQRPKVGCFSQMIFKKHKSLPLHKRNNTREKSYECKEYKKGFRKYLHLTEHLRDHTGVIPYECNECGKAFVVFQHFIRHRKIHTDLKPYECNGCEKAFRFYSQLIQHQIIHTGMKPYECKQCGKAFRRHSHLTEHQKIHVGLKPFECKECGETFRLYRHMCLHQKIHHGVKPYKCKECGKAFGHRSSLYQHKKIHSGEKPYKCEQCEKAFVRSYLLVEHQRSHTGEKPHECMECGKAFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTFKLHSYLIQHQIIHTDLKPYECKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGKTFRLNSQLIYHQTIHTGLKPYVCKECKKAFRSISGLSQHKRIHTGEKPYECKECDKAFNRSDRLTQHETIHTGVKPQKCKECGKAFSHCYQLSQHQRFHHGERLLM
Protein: E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) (Q8N7E2)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20657603}. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail. {ECO:0000269|PubMed:20657603}.
Interaction partners:
- SERTA domain-containing protein 4
- Pre-mRNA-splicing regulator WTAP
- Protein virilizer homolog
Sequence:
MNKMPAGEQECEYNKEGKYYSKGVKLVRKKKKIPGYRWGDIKINIIGEKDDLPIHFCDKCDLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLRIEAHKRGSVFMCSIVQQCKRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPPQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLSLPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPDMNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLSPQFTQTDAMDHRRWPAWKRLSPCPPTRSPPPSTLHGRSHHSHQRRHRRY
Protein: Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (O08734)
Organism: Mus musculus (Mouse)
Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q16611}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- BH3-interacting domain death agonist
- Bcl-2-related protein A1
- Apoptosis regulator BAX
- Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
- Cellular tumor antigen p53
- Bcl-2-like protein 11
- Cytochrome c, somatic
- Cytochrome c, testis-specific
Sequence:
MASGQGPGPPKVGCDESPSPSEQQVAQDTEEVFRSYVFYLHQQEQETQGAAAPANPEMDNLPLEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTAGNAYELFTKIASSLFKSGISWGRVVALLGFGYRLALYVYQRGLTGFLGQVTCFLADIILHHYIARWIAQRGGWVAALNFRRDPILTVMVIFGVVLLGQFVVHRFFRS
Protein: Protein virilizer (Q9W1R5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b.
Subcellular location: Nucleus {ECO:0000269|PubMed:11156988, ECO:0000269|PubMed:27919077}.
Interaction partners:
- Fl
- E3 ubiquitin-protein ligase Hakai
- Pre-mRNA-splicing regulator female-lethal
- N
- N
- RNA-binding protein spenito
- Protein sex-lethal
- YTH domain-containing protein 1
- THO complex subunit 2
- Cleavage and polyadenylation specificity factor subunit 5
Sequence:
MADVDDGSELLFFDTFSHEEVTDINLDLVQFPKPVFITQVRIIPLGARVQADFPGGVRLGATNPSKFDLEFFVNDLGMPAASAFENLGLLRYNQNDCIHLDCSQEKIVTDGLVLRGWYSTITLAIYGIFTNSVTEPIASPTLPCEPVGPEIANLSGEVLLQEDVLKDEWQEPMQAELLTAHKGNVSDYDPEDMEYGMSRDHYHQHAEEQEQREMRRLRRSTHSTDHSPPPPRRSHTHSESNDREYIRCSRDKGSRDWSRSPEYSSHRSRRKRSERSRSVVDEHKWPRTPPASIDSPTRPRSPDTMDYEDEDSRSHYKMQSSHYRHSSESLHRGERDRDDEDRSCTPQEQFEPILSDDEIIGDDEEDDAVDAAAIAEYERELEAAAAAAPPAIDAFEPWQKPLLVFEGDMAAHFCKELETLKLLFKKLVLQTRCENVNAFSEEHGASVDEREQFVYLGEQLNNQLGYLAQHYKRRNFVLQQFFGNDELHLRQAANVLQIALSFQAACMQPQPAFKIRHIKLGARMAELLGSSEELFQHLLKEHKFDIFEAVFRLYHEPYMALSIKLQLLKAVYALLDTRMGIEHFMGAKNNGYQMIVEAIKTAKLTRTKYALQAIIKKLHLWEGLESVQIWCRRLFVDRIIIPGNRDQMEDTVITCQQIEFAFEMLMDALFSSQLSYLQPRRFLPVSKKFEVVTDPTAQRSFGNALQSYLGQNSLAESLLVMLANCKELPATTYLSMLDLMHTLLRSHVGIDYFVDDAFPVTQTIVAILLGLDEVPRNPEEKEEKAEKSDAEDKAMEVENEAVEAGGEKPTPPTADEEGKPVAAPISVPAPAAAPQVRPRPILRPVLPRLARLGIEMSYKVQTRYHLDAIAYAAAAPEYDAVKLATHMHAIYSQTCDPAGRQHTVEVLGLNNNLKIFMDLIKKEQRLQTQRQLSSPGTKYKSPVLSYAVDMVDACVRYCEQLDYLIEHGGVILELAKNHETFEPSVSAVLQEMYVYMKPLEAINVFVYDDIMPLVEVIGRSLDYLTTFPGDLIMAMRILRYLSISKPLAGQKAPPVTEELKHRFVALQLYAADGVQLCIQIMERLCAYFEQPGAHAPALMTIQGVHCCQIMLPTLQILRELLSYAILCRDGTYKDLTAIDHLVKVYYLLYYFPTRCQAGPEVEQCKMEVVQTLLAYTQPNEQDEESLHKSLWTLMIREVLKNVDGPAHFIPGLKLLAELLPLPLPMPQPLCDQLQQQHKQRLITERKLWSAHLHPQSGQIAKLVEALAPSSFPQLSELLQRVCMQLSDLAPNMTLLIAKTITELLCNEYQTSNCIPTTNLERLLRFSTRLCAFAPLKSSMLSILSGKFWELFQSLLALNEFNDVVSNCQEAVHRILDSFLDSGISLISHKSTASPALNLAAALPPKELIPRIIDAVFSNLTSVEVTHGISILAVRNLVILTEHDFTFYHLAQLLKQKITEFQAWMERVILHNETVEYNANIESLILLLRSLTQIEPPPAMSAMPHRTLKLGATELAQLVEFQDIELAKPPVLSRILTVMEKHKAVANEAALSDLKQLILLQASKQEILAGTSTETPPEAEGEANPSASSCSASLTVEPYLPQAEGIVTQYEARPIFTRFCATAENAQLTARYWLDPLPIELIEDMNEPIYERIACDLTDLANVCLNPDLNVAGDSKRVMNLSGSPQSNREMTPTAPCFRTRRVEVEPATGRPEKKMFVSSVRGRGFARPPPSRGDLFRSRPPNTSRPPSLHVDDFLALETCGAQPTGPTGYNKIPSMLRGSRVGRNRGSRISAAAAFRQKKMMRIGSPSSWAESPGSYRSASDSHFSSSDSHYSSPHYSGRPRGRGLRSRPSYLR
Protein: 3-hydroxyacyl-CoA dehydrogenase family protein (3-hydroxybutyryl-CoA dehydrogenase-like protein) (Putative 3-hydroxybutyryl-CoA dehydrogenase) (Q9LDF5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Acetyl-CoA acetyltransferase 2
- Acetyl-CoA acetyltransferase 1
- Probable enoyl-CoA hydratase 1, peroxisomal
- 3-ketoacyl-CoA thiolase 2, peroxisomal
- Probable enoyl-CoA hydratase 2, mitochondrial
- Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2
- Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1
- 3-ketoacyl-CoA thiolase 1, peroxisomal
- 3-ketoacyl-CoA thiolase 5, peroxisomal
- Acyl-coenzyme A oxidase 4, peroxisomal
Sequence:
MAEMKSVGVVGAGQMGSGIAQLAATSGLDVWLMDADRDALSRATAAISSSVKRFVSKGLISKEVGDDAMHRLRLTSNLEDLCSADIIVEAIVESEDIKKKLFKDLDGIAKSSAILASNTSSISITRLASATRRPSQVIGMHFMNPPPIMKLVEIIRGADTSEETFLATKVLAERFGKTTVCSQDYAGFVVNRILMPMINEAFHTLYTGVATKEDIDSGMKHGTNHPMGPLELADLIGLDVCLSVMKVLHEGLGDSKYAPCPLLVQYVDAGRLGRKRGVGVYDYREATQKLSPRL
Protein: TerD domain-containing protein (Q57YU4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSAQLQQKLFRIPGNIAVSVGLHWDFVGADPVDLDLSAVAFSSEGVLLDVVFFNHPFPVGTDEEALRDCGFLVDPQQLPYMFISGDSRIGGEEENRLPGLALAARRRALQMRGGRDDELKRFGVIESIFSRIYNESELEMVEEVLNDKRGGGHIFDEDGRAFRSENSREMCDESVTFVMHKIPSEAAVIFLVVTSYTGADFSVLPTVKLVVVNEMTNEQVGTIDLKHATGNGTANLACMLCRVPTRLSGSTAPGSANGTITMDGGSRQLWDLRELNIRTFGYTFVDTLPTMMDVLGVEVNSRTNAVWQLPDYSLSKDSYGALRQPLSDVRFGVGWGGDHDLDSFMVFLDEKNNYVDHINPKPVKLQSRFPHTARHSGDAINGYSAVGDEEFIDLVTYRLPLEVHTIIFGVCYVEGGRSTRSIMDVPKFYMRLQNRTAAWPNAIEVDRWNVHEEIKRADEERKRLKEAQLQGSKSADNLPKVSELSSRLLHTYKGADGKMFPVRALVLGMMVKTAEAPLRELYPEACAQKPEGELGEVERRNSSGSPRDSDAQVATEEEDGNAAGADPLPESDTVVSVFQYLPIHEYVPISNAKGFVEMMPYMRCIAKYCRNKPSSNLATRSSADQNINNPLRLQTFQPQLSTQTSMWDQVRASSGVLSYHAVRVQFLEVRHLQPELPHVFKCHGEVWVCEKTPFTEKRSLTVYDQPTFRTPYLMHRQNMQWDESNPATAALLFVREFDRIRVVIYERAAFGYVDIDLMDINELWSQNPQPDLFVPNATQPASLMSATPAQDRWFQLSGGPLSDGLVRLRISRAPIGKLLEESERTIAAAKKKRRDHARAVEEEKHEAARERYSGPCCIM