wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I6AT99)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEDEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHAQQPPPPQQQDRSKPSYHAPEPKPHYDPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAAKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIHLLPDLLQQSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCTIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Protein: Apical merozoite protein (Q8I1P1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MYGTFLKGSIFYLCIFFPFFSCECNNIKLNDKENINFESYFNKRTNEENVLNKNVSKEMGDTFVAHKAIELNINHHHVNNDKEFNNNNNNKHQPYYHNEHDKKFSESLKAHMDHLKILNNDLKQHIDKKERNEIYENNDLKKYIIKEIQNNKYLNKEKKSSEDIQILEEHSKKLQKEIHEWLESVNNIEEKSNILKNIKSQLLNNIASLNHTLSEEIKNINDIKELQKQQNDLFSENWLYFLPSSSDYLLNEKKKNLYDNQDNSMKDDINNNDKYNIFNYLQNVQDKDNQYEVMKQDNNNIHSGSSTHNHLLLTCIIFLLILLIL
Protein: Potassium channel KAT3 (AKT4) (AtKC1) (Potassium channel TKC) (P92960)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable modulatory (alpha) subunit of inward-rectifying potassium channels. Could mediate potassium uptake from the soil solution by plant roots in association with AKT1.
Subcellular location: Membrane {ECO:0000269|PubMed:11904452}; Multi-pass membrane protein {ECO:0000269|PubMed:11904452}.
Interaction partners:
- Potassium channel AKT1
- Syntaxin-121
- Vesicle-associated membrane protein 721
- Potassium transporter 5
- Potassium inward rectifier
- CBL-interacting serine/threonine-protein kinase 23
- Calcineurin B-like protein 1
- Two-pore potassium channel 5
- Two-pore potassium channel 4
- Calcineurin B-like protein 9
Sequence:
MSTTTTEARSPLPLLLRRGRSSTALSASTAEARSPLSILQFRRRSSKDVRNITSVSSSLLPAFGTFIEDDNPSSKPFIVLHFDRRYRLWELFLVILVGYSAWASLFELAFEKAAEGALLTIDLVVDFFFAVDIILTFFVSYLDNTTYLNVTDHKLIAKRYLKSVAFVMDVASTLPIQFIYKTITGDVGRGQAFGFLNLLRLWRLRRVAELFKRLEKDAHFNYFVIRVIKLLCVTIFWIHLAGCILYWIAYHYPRPTDTWIGSQVEDFKERSVWLGYTYSMYWSIVTLTTVGYGDLHAVNSREKTFNMFYMLFNIGLTSYIIGIMTNLVVHGALRTFAMRSAINDILRYTSKNRLPDTMREQMLAHMQLKFKTAELRQEEVLQDLPKAIRSSINQHLFRSIIEEAYLFKGFPEGLLVQLVSQIQAEYFPPKMEIILQNEIPTDFYVIVSGGVDIIASKGVSEQVLAKLGPGSMAGEIGVVFNIPQPFTVRTRRLSQVIRIGHHKFKEMVQSDNDVDAKMIIANFMTYLKGLNDELKKEIPFLRDLLDDADAQVQETVQSEETPQSNDEEIVTVSRHENGQIEERRREGVPKRVIIHGQAPPNQDNKNNGDSNGRLIILPDSIQLLFDLAEKKLGKRGSTIAMADGAHVEQIDALRENDHLYIF
Protein: Protein DECREASED SIZE EXCLUSION LIMIT 1 (NbDSE1) (F1DLK1)
Organism: Nicotiana benthamiana
Function: Involved in the formation of X-, Y-shaped and twinned plasmodesmata (PD), thus modelating PD size exclusion limit and regulating cell-to-cell transport. Cell cycle checkpoint regulator that monitors and responds to DNA damage such as DNA cross-links, and triggers the halt of the cell cycle progression in the presence of DNA cross-linking agents. Mediates the active process of aluminum- (Al) dependent root growth inhibition and thus is required for response to Al toxicity. Essential for signal transduction and development of both male and female organs (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q3MV14}. Nucleus {ECO:0000250|UniProtKB:Q3MV14}.
Interaction partners:
Sequence:
MSKRPAPDPVSVLRGHRASVADICFHPSNSILFSGSTDGELRIWNTVQYRTVSSAWVHSAAHGIICVAASPVLGDNKVISQGRDGTVKCWDFGGGGLSRTPLLTIKTNSYHFCKLSIAKSPSEAMKIDDLEVNEIVDGMQREEQGDQPTDSIKFKGKELIEGPKYVAIAGEQASVVEIWDVNTAERIAQLPHSSGSPSNQTPNQRGMCMAVQAFLPSESQGLLSIMAGYEDGSIAWWDLRNLGVPLTSVKFHSEPVLSLCIDGSCKGGLSGAADEKILMFALDHSMGSCLIRKEIVLERPGIAGTSIRPDGKIAATAGWDHRVRIYNYRKGKPLAILKYHNATCNTVSFSADSKLLASASEDTTVALWELYLPRT
Protein: Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) (O95260)
Organism: Homo sapiens (Human)
Function: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:9858543}. Cytoplasm {ECO:0000269|PubMed:9858543}.
Interaction partners:
- E3 ubiquitin-protein ligase UBR2
- E3 ubiquitin-protein ligase UBR1
- Regulator of G-protein signaling 4
- Regulator of G-protein signaling 16
- Protein N-terminal glutamine amidohydrolase
- Protein N-terminal asparagine amidohydrolase
Sequence:
MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN
Protein: Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) (Q86VI4)
Organism: Homo sapiens (Human)
Function: Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:12902989}; Multi-pass membrane protein {ECO:0000269|PubMed:12902989}. Late endosome membrane {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:22096579, ECO:0000269|PubMed:25588945}. Cell membrane {ECO:0000269|PubMed:22096579}. Cell projection {ECO:0000269|PubMed:22096579}. Lysosome membrane {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:22096579}. Endosome membrane. Endosome, multivesicular body membrane {ECO:0000269|PubMed:26280656}. Endosome, multivesicular body lumen {ECO:0000269|PubMed:26280656}.
Interaction partners:
- Epidermal growth factor receptor
- Lysosomal-associated transmembrane protein 4A
- Lysosomal-associated transmembrane protein 5
Sequence:
MTSRTRVTWPSPPRPLPVPAAAAVAFGAKGTDPAEARSSRGIEEAGPRAHGRAGREPERRRSRQQRRGGLQARRSTLLKTCARARATAPGAMKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA
Protein: CXXC-type zinc finger protein 1 (A0A669KB29)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR
Protein: Ribosomal RNA-processing protein 1 (P35178)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for 27S rRNA processing to 25S and 5.8S.
Subcellular location: Nucleus, nucleolus.
Interaction partners:
- Nucleolar protein 16
- Ribosome biogenesis protein BRX1
- Ribosomal RNA-processing protein 15
- Proteasome-interacting protein CIC1
- Ribosome biogenesis protein RLP7
- Ribosome biogenesis protein 15
- ATP-dependent RNA helicase HAS1
- rRNA-processing protein EBP2
- Nucleolar complex protein 2
- Pescadillo homolog
Sequence:
METSNFVKQLSSNNRKTRVNALEALKKYLTAKQFKENKQIEFNKLWKGLYYAMWFSDRPRPQQRLANELGELHGLYFDPKDNSTADELTTNDKAFIKFSRGFWKVMCFEWFNIDRYRLDKYLLLIRRVLFSQLKYLQSRNWDKKLVDEYIKKVLRWLPLSGSPKVYTGIPIHIVDILLDEWERLLKDGDEDDEDEENKEEEMRKIAESAKKTPLADVIAIFQDIVADYNNSKVLREKIKEDLFSDTRLVSWDILEGETQHNDSSNESEEEEEEEWKGF
Protein: Gamma-soluble NSF attachment protein (N-ethylmaleimide-sensitive factor attachment protein gamma) (Q38BV1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
- Golgi SNARE protein-like
- SNARE protein, putative
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Soluble N-ethylmaleimide sensitive factor
- Syntaxin, putative
- Syntaxin 5
- Soluble N-ethylmaleimide sensitive factor
- Paraflagellar rod component
- Longin domain-containing protein
- Synaptobrevin-type vesicle transport protein, putative
Sequence:
MSTGAFTEADSLMASAKKHLKTGLFKRKPDWGSAADDYERAGGLYVSDGNVEKACEAYNSACEAYEKVGSLVSASLIKSKLAQFLAEQARKGCGGKSLDKKLMDSAVESYRGAARYYALDGKFDRMAETLVKAAELIDPTTHCAFASPLAAKSNVEGDREKVKQVCALLEEAADAIEENEDNNNSYIIRLPDIYRKWMLACLRSGDVLRAIAVLERQLGITNGSGDGTSKIKGKCAGGFYARLNQPHNVAKTGLEIIVLCLSLGDLVLARMKLDGLRGISGFANTKEESTVRSLLEAFGERDTEMLQETLKDSTLMFITNDISRMAKKLVIRSTEAKPDTCEGGEVIDGEEDLR
Protein: T. brucei spp.-specific protein (Q57UR7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- EF-hand domain-containing protein
Sequence:
MEGVASSIASVDRHIARIEYYLKRMRQNSVAHTGLVRLPSHGSALKGYHSSLRSGTTAQSQPKSCVSPKKHHHTVKNIEMGLKPEFKSRTDDIKSETKWTPLCKNIEGLTQTHAKHLPKRAESAIVGKDTKQPNMGLRGKSDEYLSRQRRKQSTGFSETNVTSALFLGATTVLGDSPPLMNTTSALLHSGESSFDSLLSKASSASFSSFEYDPAGEFATRTLQWRRAAYGLLASHYEKAFGLLYMAELEEGHSSVTAADLLSVTNLDHRFPHFSTENTSGYARPSALRNDKLNSASASSTHDLIHAERSDRGGSWSHHSILRREPQEDRSSLPNYSKHIPNKQNVGARTPPLGNRCYELLTETQHRDAVVGRTIESQEDEGVTNLLRWAGESADSAAERSAYRLQERRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESADSAAERSAYRLQERRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESADSAAERSAYRLQERRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESADSAAERSAYRLQEQRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESADSAAERSAYRLQEQRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESAASAAERSAYRLQEQRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESADSAAERSAYRLQEQRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESAASAAERSAYRLQEQRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRWAGESAASAAERSAYRLQEQRRYLQCQQLLSELQREECAIRGTIESQEDEGVTNLLRRVMRSNTLRSGSMLSVDVAGICASSDDKIVLDSEQRANTVLTTVLHELSTTREPLEGAGKSLFGVSDRSGCDISISTTTGAEAIRYSAALEHRVTTPLRVADVADQHELPAVEATYPTAEPTKGYVWTEDQSNQVVSSYSDMVSCVEEQCYISLFKLVQREARNRWHNERAEYYARNEMRWDELNCYRSLVQWPPSLSLCFEEYAGDVAGSGGGHCEIEANNTALFKDEARATEPYTDASLLCKRPHRNEPALSMVKDVTEPLEDPVPAEYQANEQSTGSLVTFDEAEHPKQHEKAVVWSINITDGRCSTPPHLRDRPWAPLLMRKSAVQGSIANDSDFTGYNVKRRKKVRGTECAGTATHGAASASGEARFVTLSRSNPCGSLQVCQKARQQGNTAAPIGYAEIYKLHLRKQRAQSLRGAQHLQPFYSKVTVSFLESAEWRYQKMYVDNYLFPSLSPMRGAPRVRKCADGVCSEVERAASIWDLAGY
Protein: Indole-3-acetate O-methyltransferase 1 (EC 2.1.1.278) (IAA carboxylmethyltransferase 1) (S-adenosyl-L-methionine:(indol-3-yl) acetate carboxylmethyltransferase 1) (Q9FLN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methylation of the free carboxyl end of the plant hormone indole-3-acetic acid (IAA). Converts IAA to IAA methyl ester (MeIAA). Regulates IAA activities by IAA methylation. Methylation of IAA plays an important role in regulating plant development and auxin homeostasis. Required for correct leaf pattern formation. MeIAA seems to be an inactive form of IAA.
Interaction partners:
- Methylesterase 17
- UDP-glycosyltransferase 84B1
- Probable indole-3-pyruvate monooxygenase YUCCA1
- UDP-glycosyltransferase 74D1
- Auxin transporter protein 1
Sequence:
MGSKGDNVAVCNMKLERLLSMKGGKGQDSYANNSQAQAMHARSMLHLLEETLENVHLNSSASPPPFTAVDLGCSSGANTVHIIDFIVKHISKRFDAAGIDPPEFTAFFSDLPSNDFNTLFQLLPPLVSNTCMEECLAADGNRSYFVAGVPGSFYRRLFPARTIDFFHSAFSLHWLSQVPESVTDRRSAAYNRGRVFIHGAGEKTTTAYKRQFQADLAEFLRARAAEVKRGGAMFLVCLGRTSVDPTDQGGAGLLFGTHFQDAWDDLVREGLVAAEKRDGFNIPVYAPSLQDFKEVVDANGSFAIDKLVVYKGGSPLVVNEPDDASEVGRAFASSCRSVAGVLVEAHIGEELSNKLFSRVESRATSHAKDVLVNLQFFHIVASLSFT
Protein: Polyamine aminopropyltransferase (Cadaverine aminopropyltransferase) (EC 2.5.1.-) (Putrescine aminopropyltransferase) (PAPT) (Spermidine aminopropyltransferase) (EC 2.5.1.79) (Spermidine synthase) (SPDS) (SPDSY) (EC 2.5.1.16) (Spermine synthase) (EC 2.5.1.22) (Thermospermine synthase) (P09158)
Organism: Escherichia coli (strain K12)
Function: Involved in the biosynthesis of polyamines which play a significant role in the structural and functional organization in the chromoid of E.coli by compacting DNA and neutralizing negative charges. Catalyzes the irreversible transfer (ping-pong mechanism) of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. Cadaverine (1,5-diaminopentane) and spermidine can also be used as the propylamine acceptor.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00198}.
Interaction partners:
- S-adenosylmethionine decarboxylase proenzyme
- Agmatinase
- Constitutive ornithine decarboxylase
- Spermidine N
- Inducible ornithine decarboxylase
- Gamma-glutamylputrescine synthetase PuuA
- Putrescine aminotransferase
- Bifunctional glutathionylspermidine synthetase/amidase
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Constitutive lysine decarboxylase
Sequence:
MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAIHTAAFALPQYLQDALASQPS
Protein: Uncharacterized protein SLP1 (SUN-like protein 1) (Q12232)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in membrane protein folding. Required for localization of MPS3 to the nuclear envelope.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11935221, ECO:0000269|PubMed:23275891}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Endoplasmic reticulum membrane protein 65
- Uncharacterized protein YNL050C
- Protein DCV1
- Uncharacterized protein YFR012W-A
- Protein HGH1
- Uncharacterized protein YLR287C
- Uncharacterized protein YGR146C-A
Sequence:
MANRLLIYGLILWVSIIGSFALDRNKTAQNAKIGLHDTTVITTGSTTNVQKEHSSPLSTGSLRTHDFRQASKVDIRQADIRENGERKEQDALTQPATPRNPGDSSNSFLSFDEWKKVKSKEHSSGPERHLSRVREPVDPSCYKEKECIGEELEIDLGFLTNKNEWSEREENQKGFNEEKDIEKVYKKKFNYASLDCAATIVKSNPEAIGATSTLIESKDKYLLNPCSAPQQFIVIELCEDILVEEIEIANYEFFSSTFKRFRVSVSDRIPMVKNEWTILGEFEARNSRELQKFQIHNPQIWASYLKIEILSHYEDEFYCPISLIKVYGKSMMDEFKIDQLKAQEDKEQSIGTNNINNLNEQNIQDRCNNIETRLETPNTSNLSDLAGALSCTSKLIPLKFDEFFKVLNASFCPSKQMISSSSSSAVPVIPEESIFKNIMKRLSQLETNSSLTVSYIEEQSKLLSKSFEQLEMAHEAKFSHLVTIFNETMMSNLDLLNNFANQLKDQSLRILEEQKLENDKFTNRHLLHLERLEKEVSFQRRIVYASFFAFVGLISYLLITRELYFEDFEESKNGAIEKADIVQQAIR
Protein: Transcriptional activator FLO8 (Protein PDH5) (P40068)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for diploid filamentous growth, haploid invasive growth and flocculation. Putative transcriptional activator of FLO1.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSYKVNSSYPDSIPPTEQPYMASQYKQDLQSNIAMATNSEQQRQQQQQQQQQQQQWINQPTAENSDLKEKMNCKNTLNEYIFDFLTKSSLKNTAAAFAQDAHLDRDKGQNPVDGPKSKENNGNQNTFSKVVDTPQGFLYEWWQIFWDIFNTSSSRGGSEFAQQYYQLVLQEQRQEQIYRSLAVHAARLQHDAERRGEYSNEDIDPMHLAAMMLGNPMAPAVQMRNVNMNPIPIPMVGNPIVNNFSIPPYNNANPTTGATAVAPTAPPSGDFTNVGPTQNRSQNVTGWPVYNYPMQPTTENPVGNPCNNNTTNNTTNNKSPVNQPKSLKTMHSTDKPNNVPTSKSTRSRSATSKAKGKVKAGLVAKRRRKNNTATVSAGSTNACSPNITTPGSTTSEPAMVGSRVNKTPRSDIATNFRNQAIIFGEEDIYSNSKSSPSLDGASPSALASKQPTKVRKNTKKASTSAFPVESTNKLGGNSVVTGKKRSPPNTRVSRRKSTPSVILNADATKDENNMLRTFSNTIAPNIHSAPPTKTANSLPFPGINLGSFNKPAVSSPLSSVTESCFDPESGKIAGKNGPKRAVNSKVSASSPLSIATPRSGDAQKQRSSKVPGNVVIKPPHGFSTTNLNITLKNSKIITSQNNTVSQELPNGGNILEAQVGNDSRSSKGNRNTLSTPEEKKPSSNNQGYDFDALKNSSSLLFPNQAYASNNRTPNENSNVADETSASTNSGDNDNTLIQPSSNVGTTLGPQQTSTNENQNVHSQNLKFGNIGMVEDQGPDYDLNLLDTNENDFNFINWEG
Protein: Anion exchange protein (Anion transporter ABTS-4b) (Q58G79)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSNGSPGRHSNKAFSIGSDDGENENVFVEETSTPPKTPLGTLLTNCTEQSPLILPMPTRPRLEDSPVAEHDHHIVVDVFTVNNDDGTWKQASRFARYEEDCEGFDNHLGRPHVPCIPMGTYDALKMVTAKSILFPKVQYESLDEFVNFLETKIVDPDVPKLGEKIAKLINDRIAEIEKMRPLHQRNSSSTQSLDASNPQTISTVGIFPRSLLSAPNNLGSLAHHPMRRLPTSHSGLRFGSSFLPQQPVVSQLEPVIWDEDNEISMLVAGEIPHVNVCRFIAIRFVETTAMEKIFPNMTNVRHLFFLIGPALENVTYLDLGRALASVVSNPPATTTFDQLKSPDSITKAIERFLAGTVVIAPGRIDNKNLVRSDLIRKLVNMQGEKTETKIVHPKDVDVERNATKKAEEAEDKPFRLFSGVTSDLRNRAKHYFSDYRDGFNISIFTVVFYMFCVTVVPTLTFGAIMGAGTSGLLAVKECLVSQALSGLIWSVLSCQPLLVMSPTGPFLVFEKALFKFTDQNDMDFLEVRFYTGIFLFFISIVGAATNCAHLIHYVTIYTEDIFCALISLIFFSEVVEFIHLQEEHNSIENLKYYIENAANCTVTEVKDCALSRPNTFLLQLIMVVVSIAIFHYLRQVSRSTFFGRTFRNLCKNFGGIFAVIAVSIAYRILFQNVGVAVVDIPVAVGQSRPFDGIFVIPSAPPTASTLTIALISSILLFVLIFVETEIPEQMALREGRKLKKGGGLHWDLIVVGFCTLVSSVLGLPWMCPAAVQSLAHITSLTEYKKSAPGVPSRISHVIEQRVSGMVTYLLLGTFAILGHFLAIPAATIFGVFFYLGVRNLEGSKMILRLKLCFLPSKYRGSHKFLEIVSSLKICIGGLLFPLFIVSNAIFVKHGLSVIFDKELLEALDSEDHDNDDADRDNEENPEDFYQNTRIPV
Protein: Cellular nucleic acid-binding protein homolog (P36627)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts in the sexual differentiation pathway. Is required for efficient conjugation. Double-stranded DNA-binding protein.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable RNA-binding protein sce3
Sequence:
MESESVPTVPQTTRPGPRCYNCGENGHQARECTKGSICYNCNQTGHKASECTEPQQEKTCYACGTAGHLVRDCPSSPNPRQGAECYKCGRVGHIARDCRTNGQQSGGRFGGHRSNMNCYACGSYGHQARDCTMGVKCYSCGKIGHRSFECQQASDGQLCYKCNQPGHIAVNCTSPVIEA
Protein: COP9 signalosome complex subunit 4 (Signalosome subunit 4) (Constitutive photomorphogenesis protein 8) (FUSCA protein 4) (FUSCA4) (P68359)
Organism: Brassica oleracea (Wild cabbage)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes (By similarity).
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
Sequence:
KRKFLDAALRYYSISQIEKKAYLPDKSTVLDRAMIEHNNLLSASK
Protein: Mitogen-activated protein kinase 7 (AtMPK7) (MAP kinase 7) (EC 2.7.11.24) (Q39027)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MKK3-MPK7 module acts as a positive regulator of PR1 gene expression.
Interaction partners:
- Mitogen-activated protein kinase kinase 3
- Protein-tyrosine-phosphatase PTP1
- Mitogen-activated protein kinase kinase 2
- Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein
Sequence:
MAMLVEPPNGIKQQGKHYYSMWQTLFEIDTKYVPIKPIGRGAYGVVCSSINRETNERVAIKKIHNVFENRVDALRTLRELKLLRHVRHENVIALKDVMLPANRSSFKDVYLVYELMDTDLHQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQESDIRFIDNPKARRFIKSLPYSRGTHLSNLYPQANPLAIDLLQRMLVFDPTKRISVTDALLHPYMAGLFDPGSNPPAHVPISLDIDENMEEPVIREMMWNEMLYYHPEAEISNA
Protein: C3/C5 convertase (A2VD28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MECALWLAIFMLTILSPLIIGAPPSISCPVKDIRIKGGSFSISKDGSSIIFNCPENYYPTIRTRRCTKGRWSELPKGKRLECKKITCPDPRAFLNGDVHPYSPRYYVNDTTRYFCQSGYDFRGSESRVCQANGKWSGSTPICGRNSDYCPDPGVPAGTTRTGNMFHIGDKVTYRCDNKLSLIGSKERTCQDNGQWSGTEPQCYADFTYDTPEEASDAFSSSLVSNLQLTQLHEETDQYGKKIQVHKGGKLDIYIALDVSDSIDEEDFERAKDVIKTLIEKISYYEVSPNYEILLFATDTDRIISMREFKNGQGKDLLKIIQKLQDYAYDKKGQRSGTNIAQAYNKIYESMTIELMTNKEDFKATQHIVIMFTDGQANMGGSPKPLVDKIKSLVRQNSVEEKLELYVFGLGNDVHAEDINDLKTDRANEKFFFKLKSLDDLKETFDNMIDEGNSVELCGLYKDYDDESESHKRRQYPWLAKISVTRSTGKNSKCMGSFVTSSFILTAAHCFKVDDTPATITIDLESENQGIKVKYIHSHPDYNIKAKLNLGIPEYYEFDVALLQLEKPVKMSVSLRPICIPCTKETNGALRLSDREGTCKKHKELLMTGETVKAAFMSEVRTKTEQKDITIKQGKLRQACVEDAKKAAGMTAEKATDIVTDNFLCSGGIDPTTDEIACKGDSGGATFVVPGGRVVQVGIVSWGVKDLCKRSPKPRSESYTRDYHTNLFSAKILSFLKKYLADEKLGTPLTFM
Protein: NTF2-related export protein 2 (Q3UNA4)
Organism: Mus musculus (Mouse)
Function: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Interaction partners:
- Tip-associated protein
- Nuclear RNA export factor 1
- Tip-associated protein
- Nuclear RNA export factor 7
- NTF2-related export protein 1
- Nuclear transport factor 2
- Nucleoporin 62 C-terminal like
- T-complex 11 family, X-linked 2
Sequence:
MALAVNFKTYVDQACRAAEEFVNIYYETMDKRRHALVRLYLDKATLIWNGNVVTGLEALANFFEMLPSSEFQINMLDCQPVHEQATQCQTTVLVVTSGVVKFDGNKQHFFNQNFLLTAQSTPNSTVWKIASDCFRFQDWASI
Protein: 2-methylcitrate dehydratase (2-MC dehydratase) (EC 4.2.1.79) (Aconitate hydratase) (ACN) (Aconitase) (EC 4.2.1.3) (Q937N6)
Organism: Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity).
Interaction partners:
Sequence:
MSTDTPSAQRPDPDQVLVDIVDYVTRYEIKSGLAYDTARNCLIDTLGCGLEALSYPACTKLLGPVVPGTIVPNGARVPGTQFQLDPVQAAFNIGAMIRWLDFNDTWLAAEWGHPSDNLGGILATADWISRNHIAAGRKPLTMKAVLAAMIKAHEIQGCIALENSFNQVGLDHVVLVKVASTAVVAQMLGLTRDEILNAVSLAWVDGQSLRTYRHAPNAGSRKSWAHGDATSRAVRLALIARTGEMGYPSVLTAKTWGFYDVLFKGQPFRFQRPYGTYVMENILLKISYPAEFHAQTAVEAAMQLHGALALAGRSAADIAAITIRTHEACLRIIDKLGPLSNPADRDHCIQYMVAVPLLFGRLTAADYEDRIAADPRIDALRGRITCVEDPALTRDYHDPAKRSIANALTVTLADGTVLDEVLVEYPLGHKRRRAEGIPLLVEKFRTNLARRFPPKQQQAILAASLDQARLEAMPVNEYLDMYAI
Protein: Het1p (A0A1D8PPA5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MSTFFDEMSKSFADVKVSDGKIDTADFLQASESLVKLFDLLGSSAFTVVKSDMTGNITKIRNKLLEDPANSATLQDLVLTEAKTKTKTATQGLLWLSRGLQFTAQAMRETVDAPGKELTVTFTDAYTKTLSKFHGMLVKPVFKLAMKACPYRKDFFEKLGADQTKVAEQLQKWLEALEGIVKIIMDFFASGNYGKGL