wanglab/gogpt-training-data huggingface dataset:
Protein: Inositol polyphosphate-related phosphatase domain-containing protein (G5EGN9)
Organism: Caenorhabditis elegans
Interaction partners:
- Probable type I inositol 1,4,5-trisphosphate 5-phosphatase
- 1-phosphatidylinositol-3-phosphate 5-kinase
- Phosphatidylinositol-3-phosphatase SAC1
- Rho-GAP domain-containing protein
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- Synaptojanin
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
- Phosphoinositide 3-kinase adapter subunit
Sequence:
MFRVFPWSGSYSSSADANTPSASGGDPKSGDSSSEKQSHQTPTRHPPWLRSSSQPATWRNSASFNEISDGNWTYCIETQNTAPAVKGFGNVPIVSYDVIEAMGDRKLKVCTVTWNINEKGVKILSHLAQKIAERGQEMDSDIFFISLQEIPSTAPTFHEEALRILEPVLNGHRLYLSHRAWSQMVIVFIRQKHLRYAIQPQVSFIASGAMAKPVRTKGAIAVCLRLYQRFIVLIGCHLSHATPQQRIQDYAKVVRTLRFPQLARFHAHAKDEIFGSDVVLWIGDLNFRVTVESNVDWRDPEKITEKTFRDVFETEELASHRKKQLAFTDFKEAPIKFPPTHKFEPDTDNYVPKRIPSFTDRVLFWVRNSEWLQNIQYDCMRGTTPSDHKAVFATFWLTVINKPVPEHYKQQKSLEREISMKTNSVDASGPVN
Protein: Signal transducer and activator of transcription (Q68SP3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
- Interferon regulatory factor 9.
- Epidermal growth factor receptor precursor.
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase
- Tyrosine-protein kinase.
- Tyrosine-protein kinase
- Receptor protein-tyrosine kinase.
- Receptor protein-tyrosine kinase.
- Receptor protein-tyrosine kinase.
- Tyrosine-protein kinase.
Sequence:
MAVWIQAQQLQGDALHQMQSLYGQHFPIEVRHYLSQWIEGQLWDAIDLENPQEELKAKRLLDSLIQELQKKAEHQVGEDGFLLKIKLGHYASQLKSTYDRCPLELVRCIKHILYTEQRLVREATNSSSPVGGLMDSMSQKYHQINQAFEELRILTQDTENDLRKLQHTQEYFIIQYQESLRIQAQLSSLATLPPADRQLREPSLLSKRATVEAWLTREANTLQKYRLSLAEKHQKTLALLRKQQTVILDDELIQWKRRQQLAGNGGPPEGGLDILQSWCEKLAETIWQNRQQIRRAEHLRQQLPIPGPIEELLTDLNSTITDIISTLVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKALLKNENTRNDSSGEILNNNCVMEYHQTTGTLSAHFRNMSLKRIRRSDRRGAESVTEEKFTILFESQFSVGGNELGFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFIVPDKVLWAQLCEALNMKYKAEVQSNRGLCEENLVFLAQKAFSSSSVNPDDYRNMTMTWSQFNRESLPGRNFTFWQWFDGVMELTKKHLKPHWNDGAILGFVNKQQAQDMLMSKPNGTFLLRFSDSEIGGITIAWVAENPNKAGERMVWNLMPYTTKDFSIRSLADRISDLNHLLFLYPDRPKDEVFSKYYTPPLSKAVDGYVKPQIKQVVPEFATPNPDPAANPTYMDHVASSPAVSAPHPYGLYPPMADPMLDADGDFDLDDTMDVARHVEELLRRPMEGQWSGQQS
Protein: Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Cyclic protein 2) (CP-2) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] (P07154)
Organism: Rattus norvegicus (Rat)
Function: Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1.
Subcellular location: Lysosome {ECO:0000269|PubMed:7777858}. Apical cell membrane {ECO:0000250|UniProtKB:P06797}; Peripheral membrane protein {ECO:0000250|UniProtKB:P06797}; Extracellular side {ECO:0000250|UniProtKB:P06797}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Secreted, extracellular space {ECO:0000250|UniProtKB:P06797}. Secreted {ECO:0000269|PubMed:7777858}. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. {ECO:0000250|UniProtKB:P06797}.
Interaction partners:
- Cathepsin B
- Serpin B13
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- BH3-interacting domain death agonist
- Cathepsin D
- Legumain
- Angiotensin-converting enzyme 2
- Transmembrane protease serine 2
- Toll-like receptor 9
Sequence:
MTPLLLLAVLCLGTALATPKFDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKKGRLFQEPLMLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIVN
Protein: Calcium binding tyrosine phosphorylation regulated (Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_a) (A0A0D9SFQ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE
Protein: Protein Jumonji (Jumonji/ARID domain-containing protein 2) (Q62315)
Organism: Mus musculus (Mouse)
Function: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10807864, ECO:0000269|PubMed:10913339, ECO:0000269|PubMed:20064375, ECO:0000269|PubMed:20064376}. Note=Colocalizes with the PRC2 complex on chromatin.
Interaction partners:
- Metal-response element-binding transcription factor 2
- Histone-lysine N-methyltransferase EZH1
- Histone-binding protein RBBP7
- Polycomb protein EED
- Histone-binding protein RBBP4
- Polycomb protein Suz12
- Zinc finger protein AEBP2
- Histone-lysine N-methyltransferase EZH2
- PHD finger protein 1
- PHD finger protein 19
Sequence:
MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNAQKRQHGEGLAGSLKAVNGLLGNAQAKALGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEDVEEEDDETEDVKATTNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSAREKEPAHKHRSKEATPGKEKHSEPRADSRREQASGAQPTAASAAASSAKGLAANHQPPPSHRSAQDLRKQVSKVNGVTRMSSLGAGTNSAKKIREVRPSPSKTVKYTATVTKGTVTYTKAKRELVKETKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAASGLKASSRLNPKSCTKEVGGRQLREGLRNSKRRLEEAQQVDKPQSPPKKMKGVAGNAEAPGKKASAASGEKSLLNGHVKKEVPERSLERNRPKRAAAGKNMLGKQAHGKTEGTPCENRSTSQPESSHKPHDPQGKPEKGSGKSGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKYGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTESDHHKFHSLPRFEPKNGLVHGVTPRNGFRSKLKEVGRAPLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMNMCFSKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQGNGTPGLQMLESNVMISPEVLCKKGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYNVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRLLFEAGLHSSARYGSHDGNSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKHGGIENCLNKPTPKRGPRKRATVDVPPSRLPSS
Protein: Autophagy-related protein 20 (Cytoplasm to vacuole targeting protein 20) (Sorting nexin-42) (Q07528)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway. Required for proper sorting of the v-SNARE protein SNC1.
Subcellular location: Endosome membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein.
Interaction partners:
- Sorting nexin-4
- Autophagy-related protein 11
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 29
- Autophagy-related protein 17
- Autophagy-related protein 31
- Autophagy-related protein 9
- Synaptobrevin homolog 1
- Putative lipase ATG15
- Autophagy-related protein 21
Sequence:
MSDLNDVQENAKLNSETRNTGKAEPPHGTTEYVAEAEISKNGVGSPKKSPKKGKVGKGDNNKVETELVHTALLEKDNPFMEEGPTGFTKSALLEIPGMRSHNLKNPNEDYEDDSEGLLPLNQESNAETCRTSLSGSINSMNGETSASEEPSVSNRKKSARIHILEAKRVSEGQGRAYIAYVIQFENSTVQRRYSDFESLRSILIRLFPMTLIPPIPEKQSIKNYGKSITGSSSKYLLPSEGSGSVDLSLSVIHASVNNSDEKLIRHRIRMLTEFLNKLLTNEEITKTSIITDFLDPNNHNWHEFVNSSSTFSSLPKSILQCNPLDPTNTTRIHAMLPIPGSSSQLLLNKESNDKKMDKERSKSFTNIEQDYKQYENLLDNGIYKYNRRTTKTYHDLKSDYNEIGEVFAQFAHEQAQVGELAEQLSYLSNAFSGSSISLEKLVGRLYYNINEPLNESVHMATSARELIKYRKLKYLQNEMIKKSLNSKRAQLEKLEAQNNEYKDVDKIIDNEMSKSHTINLERPNNNTGSGGKSYGGKLFNGFNKLASMVKDSVKYQETDPHTASINLKKEIEQLSESLEVTENDLEVISKVIKNDQLPKFSKEREVDLSEILKHYSRYMRNYARQNLEIWKEVKRHQDFA
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) (Q28619)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell projection, microvillus {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.
Interaction partners:
- Ezrin
- Radixin
- Cystic fibrosis transmembrane conductance regulator
- Moesin
- Sodium/hydrogen exchanger 3
- Podocalyxin
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- FERM domain-containing protein
- Merlin
- Beta-2 adrenergic receptor
Sequence:
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKVGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPDTDEQFRKLGVQIRGELLRAQAGPEQAGPPAAPGEQGPAGENEPREVEKSHPERRELRPRLCAMKKGPNGYGFNLHSDKSRPGQFIRAVDPDSPAEASGLREQDRIVEVNGVCVEGKQHGDVVTAIKAGGDEAKLLVVDKETDEFFKKCKVVPSSEHLNGPLPEPFTNGEIQKNNPETLAPAASESPRPALARSASSDTSEELASQDSPKKEDSTAPSSTSSSSDPILDFSISLAVAKERAHQKRSSRRAPQMDWSEKKELFSNL
Protein: Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (T-DSP11) (Vaccinia H1-related phosphatase) (VHR) (Q9D7X3)
Organism: Mus musculus (Mouse)
Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16845380}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37865089}.
Interaction partners:
- Serine/threonine-protein kinase VRK3
- Tyrosine-protein phosphatase non-receptor type 7
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 14
- Stress-activated protein kinase JNK
- Receptor-type tyrosine-protein phosphatase R
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 13
Sequence:
MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKVKL
Protein: Armadillo repeat-containing protein 12 (Q5T9G4)
Organism: Homo sapiens (Human)
Function: Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (By similarity). Facilitates the growth and aggressiveness of neuroblastoma cells. Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:30026490}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q80X86}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80X86}.
Interaction partners:
- Histone-binding protein RBBP4
Sequence:
MGKSIPQYLGQLDIRKSVVSLATGAGAIYLLYKAIKAGIKCKPPLCSNSPICIARLAVERERHGRDSGELRRLLNSLECKQDEYAKSMILHSITRCVYLLEAEASACTTDDIVLLGYMLDDKDNSVKTQALNTLKAFSGIRKFRLKIQEHSIKVLELISTIWDTELHIAGLRLLNNLPLPDYVHPQLRRVMPALMEILQSDYILAQVQAVRLLSYLAQKNDLLYDILNCQVHSNFLNLFQPTQSGSLLYEVLVFAERLSEGRNAPHYHVVKWHYNEQSLHESLFGEESRLADRLLALVIHPEEDVQIQACKVIVSLQYPQDLRARPSSCQPSRSYFKNTE
Protein: BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein homolog) (Light-ear protein) (Le protein) (Q99KG7)
Organism: Mus musculus (Mouse)
Function: Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
Interaction partners:
- BLOC-3 complex member HPS1
- BLOC-2 complex member HPS6
- BLOC-2 complex member HPS5
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- BLOC-2 complex member HPS3
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Homogentisate 1,2-dioxygenase
- Biogenesis of lysosome-related organelles complex 1 subunit 4
Sequence:
MATTTPPETKSAAWWNYFFLYDGSKVKGEGDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRMRNLKFAIRADGDYLWALGCGVEISDASCRQFLDQLIGFFHFYMGPVSLAYKSHPQEELSLQWDTSITQVLRSTSESHRIFNALWNLDRTKVEPLLLLKAALILQTCQRSPHVLAGCILYKGLIVNSQLLPSLTAKVLLHQTVPADQRLPGAGAAPQETGAALPPDVQITSVFLSEEEVASLHEFPVEHETRLQGSSVQYPPWDQSSPTQAEDAWASAAIPEPTPHDGACPSGSGADERLPRLEQECAGPTGLCTTACGQGSGLSSRLQKELCLSREELDSSEMHVSEAQEAFPPLPALGDLETLHSSHSAPTLPEDTAICSCLHPCPLERLPESGRLGQLADLPLTNGQTQVPGTDPLPSSMPVALPPQHPVGVEPSVEPYGNGAQESHSALPRSSRSPDSPGPSPSADRTGFKPSPSGRHAGLVPMNLYTHSVNGLVLSLLAEETLLSDTAAIEEVYHSSLASLNGLEVHLKETLPRDEASLTSSTYNFLHYDRIQSVLSANLPLVTAPQDRRFLQAVNLMHSDFALLPMLYEMTIRNASTAVYACSSPAQETYFQQLAPTARSSGFPNPQDCAFSLAGKAKQKLLKHGVNLL
Protein: Angiogenin-1 (EC 3.1.27.-) (P10152)
Organism: Bos taurus (Bovine)
Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P03950}. Nucleus {ECO:0000250|UniProtKB:P03950}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P03950}. Note=The secreted protein is rapidly endocytosed by target cells following interaction with PLXNB2 receptor and translocated to the cytoplasm and nucleus. In the nucleus, accumulates in the nucleolus and binds to DNA. {ECO:0000250|UniProtKB:P03950}.
Interaction partners:
- Angiogenin-2
- Spermadhesin-1
Sequence:
MVMVLSPLLLVFILGLGLTPVAPAQDDYRYIHFLTQHYDAKPKGRNDEYCFNMMKNRRLTRPCKDRNTFIHGNKNDIKAICEDRNGQPYRGDLRISKSEFQITICKHKGGSSRPPCRYGATEDSRVIVVGCENGLPVHFDESFITPRH
Protein: Zinc finger protein ZIC 5 (XZic5) (XlZic5) (Zinc finger protein of the cerebellum 5) (Q9IB89)
Organism: Xenopus laevis (African clawed frog)
Function: May bind to DNA (By similarity). Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Does not induce anterior neural tissue.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MFGKDGRGGKIRTVSVDGLDCALMEPPLSKRSQTLRLADLAATQAHPHHNMTGFPGLGSHQSHSLPAHMHPGELGSDPGVALTPFGPEHMAQATALKLSPSAHPEAQTAAAFASPATVSYPVAHPHSGYSTSRDFILRRELSTSAMLGEQHPAAGSPHHHHHHHPHSMFISSTGSYAHPEGVGHPLFPAIHEQAAAGVHHPLNGQMRLGLAGELYGRPEAFRAEHYAASSLHHSYNSMNLNVNIAAAHPATAGAFLRYMRQPIKQELICKWIDQDQSSKKPCSKTFSTMHELVNHVAVEHVGGPEQSNHICFWEECAREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKVRGCDKSYTHPSSLRKHMKIHCKSPPGSPTNGSMGYPAVGTPLDDPLSPAQEQVRGRSSNLSPQVTNLNEWYVCQATGATVNMHTASSNADSSESEDDEETYRHSERTIR
Protein: Transcription initiation factor TFIID subunit 6 (TBP-associated factor 50 kDa) (TAFII-50) (TAFII50) (TBP-associated factor 6) (O74462)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- TATA-box-binding protein
- Putative transcription initiation factor TFIID 111 kDa subunit
- SAGA complex/transcription factor TFIID complex subunit Taf5
- Transcription initiation factor TFIID subunit 11
- SAGA complex/transcription factor TFIID complex subunit Taf10
- Transcription initiation factor TFIID subunit 8
- SAGA complex/transcription factor TFIID complex subunit Taf12
- Transcription initiation factor TFIID subunit 13
- SAGA complex subunit Spt7
- Transcription initiation factor TFIID subunit 2
Sequence:
MSLTVWNIESIKDVAEMLGIGNLADEPAAAIAMDLEYRIHQVVQEATKFMVHSKRTVLTSADISSALRTLNVEPLYGFNNSRPLEFHEAAVGAGQNSLYYLDDEEVDFEKIINAPLPKVPRNISYSAHWLAIEGVQPAIPQNPTPSDHTVGEWASKGTSGVMPGASTAAKEARNGVTSMDNVEIKPLVRHVLSKELQLYFERITSALLDETNVELRDAALSSLRDDPGLHQLLPYFIMFLSDSVTRNLGNLVVLTTLMHMAWALLDNPNLFVEPYVQQLMPSILTCLVAKRLGSDPNNHEHYALRDLAAFLLGIVCDRFGNVYYTLKPRVTRTALKAFLDNTKPYSTHYGAIKGLKTMGKEAIRVLVVPNIKVYEVLVRKTLEKGNEEEIYEANKCMDALYDALLLLRDDQLPNQRTLPPNASGLLEKNVGSLMAEKIMKENDTSLLLGLLE
Protein: Zinc-regulated transporter 2 (Low-affinity zinc transport protein ZRT2) (Q12436)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low-affinity zinc transport protein. Active in zinc-replete cells and is time-, temperature- and concentration-dependent and prefers zinc over other metals as its substrate.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Zinc-regulated transporter 1
- Zinc-responsive transcriptional regulator ZAP1
- Zinc-regulated transporter 3
- Vacuolar zinc transporter ZRC1
- Low-affinity Fe
- Vacuolar zinc transporter COT1
- Probable zinc transporter MSC2
- Zinc transporter YKE4
- Protein ZPS1
- Protein ZRG17
Sequence:
MVDLIARDDSVDTCQASNGYNGHAGLRILAVFIILISSGLGVYFPILSSRYSFIRLPNWCFFIAKFFGSGVIVATAFVHLLQPAAEALGDECLGGTFAEYPWAFGICLMSLFLLFFTEIITHYFVAKTLGHDHGDHGEVTSIDVDAPSSGFVIRNMDSDPVSFNNEAAYSIHNDKTPYTTRNEEIVATPIKEKEPGSNVTNYDLEPGKTESLANELVPTSSHATNLASVPGKDHYSHENDHQDVSQLATRIEEEDKEQYLNQILAVFILEFGIIFHSVFVGLSLSVAGEEFETLFIVLTFHQMFEGLGLGTRVAETNWPESKKYMPWLMGLAFTLTSPIAVAVGIGVRHSWIPGSRRALIANGVFDSISSGILIYTGLVELMAHEFLYSNQFKGPDGLKKMLSAYLIMCCGAALMALLGKWA
Protein: Tr-type G domain-containing protein (Q22174)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDFMISHFCDEQNHQPLYKTRRQSISDSKNGPTLLSSSLPTNDECSDSDTENRLPPETELGNIEYKAKLVNPTTSRIQHLITQMKWRLREGQGEAIYEIGVEDGGIMSGLTDEELNDSLRTLRTMAQALGASMVILTEKDVTVKGSNSRRTVVEVLVRKVPESQQFIEVRLAVVGGCDVGKSTLCGVLTQGCLDDGNGKARIGIFRFPHEVRTGKTSSVCNDVIGFDNRGKLVNYAQNSLEEMVEKSSKLVTLIDLAGDAKYQKTTIHGLTGYTPHFACLVVAADRGITWATREHLGLIAALNIPMFVLITKMDLVDRQGLKKIIKDVSNLVAKAGMTAREKRVKTKRDAVKAAQELCVGSIVPVLAVSSVSGEGFRCLRTLLNCLSTAGTAESRIQLVGLPAFFTIEELYNVPHVGQVVGGMLSEGQLHEGADVLVGPMKDGTFEKITVGSIRRSRQAVGCVNPGEAASISLNLPDGVSLRRGMVLAEIDHQPPVCYEFTANLLLLCHSTKYICEGFQATVFIGSVCTTAIITHIDDADCIRPGKWAVVKMCFAYQPEVIREGSPIILRQGKTKGMGEVLKVFPCTQ
Protein: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase (EC 2.1.1.229) (tRNA methyltransferase 9 homolog) (AtTRM9) (Q94A09)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA.
Interaction partners:
- Multifunctional methyltransferase subunit TRM112 homolog B
- Multifunctional methyltransferase subunit TRM112 homolog A
- Alkylated DNA repair protein ALKBH8 homolog
- tRNA
- DNA N
- DNA oxidative demethylase ALKBH2
- Phosphatidylinositol N-acetyglucosaminlytransferase subunit P-like protein
- RNA-binding NOB1-like protein
- Cytoplasmic tRNA 2-thiolation protein 1
- GPI-anchored adhesin-like protein
Sequence:
MILDVLRTFSTRTRNLPSSGFYSISTSIMRDIKVKSDSKEFLTSSDEEEESVSIRVSSSSSLSSVKSTPEIEKKYVHRVYDAIAPHFSSTRFAKWPKVAAFLESLPSGSVILDAGCGNGKYLGLNPSCFFIGCDISHPLIKICSDKGQEVLVADAVNLPYREEFGDAAISIAVLHHLSTENRRKKAIEELVRVVKPGGFVLITVWAAEQEDTSLLTKWTPLSAKYVEEWVGPGSPMNSPRVRNNPFFSLESIPETEVSTKEQKVENSQFIGLESIPESEESTREQKGESIIPETKASIVEQKDEKSVEESLEALKKSQQEYFVPWHLPYHRAEVSGASASALASGLAKKDDRKGAVVYNRYYHVFSEGELERLASGVGNAMIVDRFFDKSNWCIVLQKEALNQD