wanglab/gogpt-training-data huggingface dataset:
Protein: Probable WRKY transcription factor 20 (WRKY DNA-binding protein 20) (Q93WV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SI37}.
Interaction partners:
- Mitogen-activated protein kinase 19
Sequence:
MNPQANDRKEFQGDCSATGDLTAKHDSAGGNGGGGARYKLMSPAKLPISRSTDITIPPGLSPTSFLESPVFISNIKPEPSPTTGSLFKPRPVHISASSSSYTGRGFHQNTFTEQKSSEFEFRPPASNMVYAELGKIRSEPPVHFQGQGHGSSHSPSSISDAAGSSSELSRPTPPCQMTPTSSDIPAGSDQEESIQTSQNDSRGSTPSILADDGYNWRKYGQKHVKGSEFPRSYYKCTHPNCEVKKLFERSHDGQITDIIYKGTHDHPKPQPGRRNSGGMAAQEERLDKYPSSTGRDEKGSGVYNLSNPNEQTGNPEVPPISASDDGGEAAASNRNKDEPDDDDPFSKRRRMEGAMEITPLVKPIREPRVVVQTLSEVDILDDGYRWRKYGQKVVRGNPNPRSYYKCTAHGCPVRKHVERASHDPKAVITTYEGKHDHDVPTSKSSSNHEIQPRFRPDETDTISLNLGVGISSDGPNHASNEHQHQNQQLVNQTHPNGVNFRFVHASPMSSYYASLNSGMNQYGQRETKNETQNGDISSLNNSSYPYPPNMGRVQSGP
Protein: Recombination endonuclease VII (Endo VII) (EC 3.1.-.-) (Gene product 49) (gp49) (P13340)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Cleaves DNA cruciform and Y-structures as well as heteroduplex loops. Resolves Holliday junctions, recognizes a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches.
Interaction partners:
Sequence:
MLLTGKLYKEEKQKFYDAQNGKCLICQRELNPDVQANHLDHDHELNGPKAGKVRGLLCNLCNAAEGQMKHKFNRSGLKGQGVDYLEWLENLLTYLKSDYTQNNIHPNFVGDKSKEFSRLGKEEMMAEMLQRGFEYNESDTKTQLIASFKKQLRKSLK
Protein: Large ribosomal subunit protein uL18c (50S ribosomal protein L18, apicoplastic) (Q6LFD5)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Plastid, apicoplast {ECO:0000305}.
Interaction partners:
- Mitochondrial ribosomal protein L11, putative
- Ribosomal protein S16, mitochondrial, putative
- Small ribosomal subunit protein uS5
- Apicoplast ribosomal protein S14p/S29e, putative
- 40S ribosomal protein S11, putative
- Large ribosomal subunit protein uL4m
- 40S ribosomal protein S5, putative
- Ribosomal protein L13
- 30S ribosomal protein S2, putative
- 40S ribosomal protein S18, putative
Sequence:
MYISFILFSIIFIFLGVIENFIINKRVLYKPNFLLYSEKKNKKKSTPEQVTTRVNKDLKEKKRKRPRSKILECLLKEKVEKVEKVEKNSDENQCSNVDKEIREGKRVPRLRVRNTNNHIYASIIDDYKKYVLCSTCSRDATLSKILGTYRRKATNRVINNGRTIKSAWEIGKIIGKKALSKGIFKVRFDRARHPYAGKVEALAEGARAVGLLL
Protein: Cathepsin L1-like isoform X1 (Cathepsin L1-like precursor) (Cathepsin Lb) (MGC174155 protein) (Procathepsin L-like) (A7MCM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMFALLVTLCISAVFAASSIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGIMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPRGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM
Protein: Large ribosomal subunit protein bL19cz (50S ribosomal protein L19-1, chloroplastic) (Q8W463)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Located at the 30S-50S ribosomal subunit interface and binds directly to 23S ribosomal RNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein bL31c
- Large ribosomal subunit protein bL28c
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- 50S ribosomal protein L33
- Large ribosomal subunit protein uL5c
- Small ribosomal subunit protein uS9c
- Large ribosomal subunit protein bL21c
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein bL9c
Sequence:
MAMSFHRLPQALHMIPRNPTQSSKNLGFSSFLSCAPSMDSRISVSRLSLNHPGSKFGFSLDTRVRNEFIVRAEEGNTEAESEEFVAEIADTEGNVEEVVEAKPTRKPRIKLGDVMGILNQKAIEVAEKVRPVPEIRTGDIVEIKLEVPENKRRLSIYKGIVMSRQNAGIHTTIRIRRIIAGIGVEIVFPIYSPNIKEIKVVSHRKVRRARLYYLRDKLPRLSTFK
Protein: Cyclin-dependent kinases regulatory subunit 2 (Q9SJJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Interaction partners:
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B2-2
- Cyclin-D5-1
- Cyclin-A3-4
- Putative cyclin-A3-1
- KIN14B-interacting protein At4g14310
- Cyclin-B2-4
Sequence:
MGQIQYSDKYFDDTFEYRHVVLPPEVAKLLPKNRILSESEWRAIGVQQSRGWVHYAIHRPEPHIMLFRRPLNYQQEHQAQIAK
Protein: Calcium-activated potassium channel subunit beta-2 (BK channel subunit beta-2) (BKbeta2) (Calcium-activated potassium channel, subfamily M subunit beta-2) (Charybdotoxin receptor subunit beta-2) (K(VCA)beta-2) (Maxi K channel subunit beta-2) (Rbeta3) (Slo-beta-2) (Q811Q0)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity).
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Calcium-activated potassium channel subunit alpha-1
- Small conductance calcium-activated potassium channel protein 1
- Small conductance calcium-activated potassium channel protein 3
- Calcium-activated potassium channel subunit beta-4
- Small conductance calcium-activated potassium channel protein 2
- Intermediate conductance calcium-activated potassium channel protein 4
- Calcium-activated potassium channel subunit beta-1
- Potassium channel subfamily U member 1
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQRALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR
Protein: Probable transcription factor KAN4 (Protein ABERRANT TESTA SHAPE) (Protein KANADI 4) (Q9FJV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that regulates carpel integuments formation. Required for the specification of polarity in the ovule inner integument. Modulates the content of flavonols and proanthocyanidin in seeds.
Subcellular location: Nucleus {ECO:0000269|PubMed:20444210}.
Interaction partners:
- Auxin response factor 3
- Auxin response factor 4
- Axial regulator YABBY 5
- Putative axial regulator YABBY 2
- Axial regulator YABBY 4
- Axial regulator YABBY 1
- Axial regulator YABBY 3
- Serine/threonine-protein kinase UCN
- Putative homeobox-leucine zipper protein ATHB-51
- Transcription factor AS1
Sequence:
MMMLESRNSMRASNSVPDLSLQISLPNYHAGKPLHGGDRSSTSSDSGSSLSDLSHENNFFNKPLLSLGFDHHHQRRSNMFQPQIYGRDFKRSSSSMVGLKRSIRAPRMRWTSTLHAHFVHAVQLLGGHERATPKSVLELMNVKDLTLAHVKSHLQMYRTVKCTDKGSPGEGKVEKEAEQRIEDNNNNEEADEGTDTNSPNSSSVQKTQRASWSSTKEVSRSISTQAYSHLGTTHHTKDNEEKEDTNIHLNLDFTLGRPSWGMEYAEPSSDLTLLKC
Protein: Transmembrane protein (F4KAA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transmembrane protein
- Serine rich endogenous peptide 12
- Cysteine protease-like protein
Sequence:
MATKTSNFVSLRVSLFILLLFISSQVAIADAKHLQHSTTIKKSKRSSIQSTDAACAAATTTAPAPDAECSHTSPNAAVVTTAAENACIITAATNALSTSFVAVCFIADVYITKEKDDAGGSRITKKEADASCDDECKKIK
Protein: SH3 and cysteine-rich domain-containing protein 3 (Q8BZ71)
Organism: Mus musculus (Mouse)
Function: Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29467163}. Cell membrane, sarcolemma {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163, ECO:0000305|PubMed:25548159}; Peripheral membrane protein {ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163, ECO:0000305|PubMed:25548159}; Cytoplasmic side {ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163, ECO:0000305|PubMed:25548159}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29363593}. Note=Co-localizes with CACNA1S and CACNA1C on T-tubules. {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29363593}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Ryanodine receptor 1
- Voltage-dependent L-type calcium channel subunit beta-1
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent L-type calcium channel subunit beta-4
- Voltage-dependent L-type calcium channel subunit beta-3
- Cation channel sperm-associated protein 2
- EF-hand calcium-binding domain-containing protein 9
Sequence:
MTEKEVVESPQPPFPGETPQSGLQRLKQLFKKGSPETAEMEPPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFRRAYSSPLYSDQQYAVSAANRNDPVFETLRVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQDGNNAEKDKKAEKKTPDDKNKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI
Protein: Aspartate aminotransferase, cytoplasmic (EC 2.6.1.1) (Transaminase A) (O42652)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a key role in amino acid metabolism.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative alanine aminotransferase
- Malate dehydrogenase, mitochondrial
- Probable L-lactate dehydrogenase
- Probable NAD-specific glutamate dehydrogenase
- Aromatic amino acid aminotransferase C569.07
- Probable prephenate dehydrogenase [NADP
- Aspartate aminotransferase, mitochondrial
- NADP-specific glutamate dehydrogenase
- Aromatic amino acid aminotransferase C56E4.03
- Probable 3-mercaptopyruvate sulfurtransferase
Sequence:
MSDYGFANIEEAKADAIFKLNAQYHQDEDPKKVNMSVGAYRDDTGKPWILPAVKKASKIVEEQASFNHEYLPIAGLPRFTKAAAEVLFRPNPHLLSEDRVASMQSVSGTGANFLAASFIETFYVKHTGAHVYISNPTWPVHRTLWEKLGVTVDTYPYWDAKNRSFDYEGMLSTIKSAPEGSIFLLHACAHNPTGIDPTREQWLSIFESLLSRKHLVVFDIAYQGFASGDLNRDSWALNEFVKYNKDFFVCQSFAKNMGLYGERTGCMHYVAKDASTKNKVLSQLCIVQRNTISNPPAYGARIAAEILNSPQLFAEWEQDLKTMSSRIIEMRKRLRDSLVALKTPGSWDHITQQIGMFSFTGLTPAQVQFCQERYHLYFSANGRISMAGLNNSNVEHVAQAFNHAVRELP
Protein: Growth hormone receptor (Q0R5V0)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
EGKLEEVNTILAIHDNYKHEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHEKSLNIFGAKDDDSGRTSCYEPDILEADFHVSDMCDGTSEVAQPQRLKGEADISCLDQKNQNNSPSNDAAPASQQPSVILVEENKPRPLLIGGTESTHQAVHTQLSNPSSLANIDFYAQVSDITPAGNVVLSPGQKNKTGNPQCDTHPEVVTPCQANFIVDNAYFCEVDAKKYISLAPHVEAESHVEPSFNQEDIYITTESLTTTAGRSGTAEHVPSSEIPVPDYTSIHIVQSPQGLVLNATALP
Protein: Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24) (Q9CQM0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Aminomethyltransferase, mitochondrial
- Tubulin polyglutamylase complex subunit 2
- Tubulin polyglutamylase complex subunit 1
- Leucine-rich repeat-containing protein 49
Sequence:
MSRVLVPCHVKSTVALQVGDMRTSQGRPGVLVVDVTFPNIAPFELQEIMFKNYYTAFLSIRVRQQSSMHTAAKWVTCLRDYCLMPDPHSEEGAQDYVSLFKHQMLCDMNRVLELRLILRQPSPLWLSFTVEELQIYQQGPKSPSLAFPKWLSHPVSNEQPAPRLEGLPDPSRVSSEVQQMWALTEMIRASHTSTRIGRFDVDGCYDLNLLSYT
Protein: Ribosomal RNA-processing protein 7 (P25368)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2. Is required for efficient association of RPS27 with the pre-ribosomal particle.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 13
- U3 small nucleolar RNA-associated protein 18
- RNA cytidine acetyltransferase
- rRNA processing protein RCL1
- U3 small nucleolar RNA-associated protein MPP10
- Periodic tryptophan protein 2
- NET1-associated nuclear protein 1
- Ribosome biogenesis protein ENP2
- Casein kinase II subunit alpha
- U3 small nucleolar RNA-associated protein 8
Sequence:
MGIEDISAMKNGFIVVPFKLPDHKALPKSQEASLHFMFAKRHQSSNSNESDCLFLVNLPLLSNIEHMKKFVGQLCGKYDTVSHVEELLYNDEFGLHEVDLSALTSDLMSSTDVNEKRYTPRNTALLKFVDAASINNCWNALKKYSNLHAKHPNELFEWTYTTPSFTTFVNFYKPLDIDYLKEDIHTHMAIFEQREAQAQEDVQSSIVDEDGFTLVVGKNTKSLNSIRKKILNKNPLSKHENKAKPISNIDKKAKKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKRKFNPYT
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (B0S8I4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein salvador homolog 1
- WW domain-containing transcription regulator 1
- Transcriptional coactivator YAP1
- MOB kinase activator 1A.
- MOB kinase activator 1Ba)
- Merlin
- Serine/threonine-protein kinase 3
- TEA domain family member 1a.
- Angiomotin.
- Chromosome 2 open reading frame 6.
Sequence:
MRPKTFPATPYVGNTRQRLQDIKEGLKQPAKLVSQALHGGSSRGEGGRGGDSKGKDQAARQQQLRPPQKFNNYQSALREIRKSLRPYANDSGPGSSSGHPGEVSRQMLQDLVNAGCDQEMAVRALKQTGSRNIEAALEYISKMSYLDPHTEQIVRVIKQTSPGKSGMPNLMDHRTAMEGSGDGALPPYHQMGAPLYEGASYGAEGEMARAYMGGPPVMNYMPPPANPSQGATMGNPMGRPASMGAYSTNMAPQNNTGNPMYTPGPAQQKGYPSGIDQAMMGYSVSGPPMQIQSQPSGGPGAHYDYRSHMMENSSYGVKRSASFQNKMPQLTTENYVNMPSKAAMGQNAGGYAPNLYLPPHSHPRQASPTSHQVHMMQRPPGVAPGAMGGEFSDVPQGLLTPSRASLNLDLYEHHWPGAQGPEGTPPARQPQGPFRGEVRVPSRTNSFNNHQKVTVRQTLPPTASVAGKPESSLGPPNTITAVTSPPIQPPVKSIRVMRPEPKTAVGPCHPGWLSAQSPEAQDSLGYIPDENFTLEPSQEHRCPPPPYPKTLLVSGSGPEPASLEPVAMSGLQDVSATGRTIQSSSVGKQEESIFKDKVKMGKGEKAVKDKKQIQTSPVPVRKNARDEEKRESRIKSYSPFAFKFYMEQHVENVMKTYQQKLNRRMQLEQEMSKAGLSEAEQEQMRKMLYQKESNYNRLRRAKMDKSMFVKIKTLGIGAFGEVCLTRKVDTGALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVRLYYSFQDRDNLYFVMDYIPGGDMMSLLIRMGVFPEVLARFYVAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPSDFWDDVSNCRCGDRLMTLEQRATRQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLQVPPQVKLSPEAVDIIGQLCCSAEERLGGNGAGEIKAHPFFSEVDFSSNLRTQPAPYRPKIAHPMDTSNFDPVEEEGGPGAWSDSGDSTRTWDTLCSPHGKHPEHAFYEFTFRRFFDDNGCPFRYPKPLEATQSLSSSDGAGSLKPELEEEEAHEEEEQGEGCEPVYV
Protein: Liquid facets, isoform B (Liquid facets, isoform D) (Q7KU90)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MQVNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYIDGPSQRDLPPGWQEEPPKSVSELEMVRPQTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRLQLALSQSEQDFKDPNGRPIPAPKKEEQQSHLLDLLDISLGATSISSPPLGAAGGAPTAVVDPWAMPGPRAPSQLSDPWSGTSSPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNGNANQNGRGATPAGPPAEGWLIKSTAVGALGAAPINHAANNGSSSSDPWLAEPAASAAGGAAAVGLADPWAPGAASQTGAGALDDPWKALGTGAIKKQSPEFDEFDLITNRNKSEHSNSNASNNNNASLLDDMDPLSANYGNGGINSSMHPSTGATAKKSIKDAHSFLGENSALVNLDNLIKPIAPQTQTGNQPAYNPFSDNVVPPKTNLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPVMGGVSTTSQPKLPPPVRPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNLQVYNNAYQSSSSTNILGKSNIPTNMNSSTSNSTIHSCYASPSPGVDGIRNMDIFTERPYYNSPTAPADDTYMYNSRDNNNINSNYGTPSLYSSFAASYSSALSDSLAETPGISVAPLGFVADTVMSFGPSSSSANCKLEQNNNMPWIKPEAATNPFLS
Protein: Protein AST1 (ATPAse stabilizing protein 1) (P35183)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Lipid raft-associated protein involved in the targeting of PMA1 from Golgi to the plasma membrane. May induce clustering of PMA1, which facilitates partition of PMA1 into lipid rafts after leaving the ER and its transport to the cell surface.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11739806}; Peripheral membrane protein {ECO:0000305|PubMed:7822420}. Membrane raft {ECO:0000269|PubMed:11739806}; Peripheral membrane protein {ECO:0000305|PubMed:7822420}. Golgi apparatus membrane {ECO:0000269|PubMed:11739806}; Peripheral membrane protein {ECO:0000305|PubMed:7822420}. Late endosome membrane {ECO:0000269|PubMed:11739806}; Peripheral membrane protein {ECO:0000305|PubMed:7822420}.
Interaction partners:
Sequence:
MAKDILKNQDPKLQAMIVEHSAPAPKEIPMDAPVLKRVARPLRHVKFIPIKSLIFHTKTGPMDFSYEKKIKTPIPKNKIVVRVSNVGLNPVDMKIRNGYTSSIYGEIGLGREYSGVITEVGENLNYAWHVGDEVYGIYYHPHLAVGCLQSSILVDPKVDPILLRPESVSAEEAAGSLFCLATGYNILNKLSKNKYLKQDSNVLINGGTSSVGMFVIQLLKRHYKLQKKLVIVTSANGPQVLQEKFPDLADEMIFIDYLTCRGKSSKPLRKMLEEKKISQYDPVEDKETILNYNEGKFDVVLDFVGGYDILSHSSSLIHGGGAYVTTVGDYVANYKEDIFDSWDNPSANARKMFGSIIWSYNYTHYYFDPNAKTASANNDWIEQCGDFLKNGTVKCVVDKVYDWKDHKEAFSYMATQRAQGKLIMNVEKF
Protein: Calmodulin-1 (P0DP23)
Organism: Homo sapiens (Human)
Function: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P0DP26}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Interaction partners:
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Nitric oxide synthase 3
- Protein phosphatase 3 catalytic subunit alpha
- Calcium/calmodulin-dependent protein kinase kinase 2
- Nitric oxide synthase, inducible
- Ryanodine receptor 1
- Myristoylated alanine-rich C-kinase substrate
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Sodium channel protein type 5 subunit alpha
- Potassium voltage-gated channel subfamily KQT member 1
Sequence:
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Protein: RECK protein (Q6P9E2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATVRASLRGALPLLLAVTGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDMFEFFANEQLLLL
Protein: Universal stress protein F (P37903)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Universal stress protein E
- Universal stress protein D
- Universal stress protein A
- Universal stress protein C
- Universal stress protein B
- Cold shock-like protein CspD
Sequence:
MNRTILVPIDISDSELTQRVISHVEEEAKIDDAEVHFLTVIPSLPYYASLGLAYSAELPAMDDLKAEAKSQLEEIIKKFKLPTDRVHVHVEEGSPKDRILELAKKIPAHMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR
Protein: Zinc finger protein 350 (M0R017)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDIWKVDHVLERLQSESLVNRRKPCHEHDAFENIVHCSKSQFLLGQNHDIFDLRGKSLKSNLTLVNQSKGYEIKNSVEFTGNGDSFLHANHERLHTAIKFPASQKLISTKSQFISPKHQKT
Protein: Potassium channel subfamily K member (E7F9D1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- E3 ubiquitin-protein ligase NEURL1
- Cullin-associated NEDD8-dissociated protein 2)
- Potassium voltage-gated channel interacting protein 1.
Sequence:
MKRQNVRTLALIICTLSYLLIGAGVFDALESKQEKSQKGRLDYRKFLLMHKYNLTRLDFDQIEKVVLLLKPHKAGVQWKFSGSFYFAITVITTIGYGHAAPSTDAGKAFCMGYALLGIPLTLVMFQSLGERINTFVRFLLHKAKKCMGLRRPEVSMANMVIIGFFSCVSTLCIGAAAFSHYEGWTFFHAFYYCFITLTTIGFGDYVALQKDNALQNDPHYVAFSFVYILMGLTVIGAFLNLVVLRFMTMNTEDERRDAEQRALLSKDKHQGPVLRRAEPPSPSAVGRDKRRGLKSVYAEVLHFQTVCSCLWYRSREKLVILPQDLSFTDALMEQGDVSPHHFFENGPTGCVCNPQRCSAISTVSADLRNISPFRLFSKRRSSV
Protein: Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) (O35493)
Organism: Mus musculus (Mouse)
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:9307018}.
Interaction partners:
- Dual specificity protein kinase CLK1
Sequence:
MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRPCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKRK
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (O77069)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MGGGSGACPPAHMYGAVAPQDIIVRDMVQMPPPPSNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYAVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTSQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPNPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPRAAA
Protein: Receptor expression enhancing protein A, isoform Q (A0A0B4LH91)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPIYQQEPPLFYQRPANLRRLRHPPGTVYGRSYSLEDQPEDVIPVYPKFIYAPQQQQQQQRAPYPLYQLGDSLSSLDSDFPENEYAGAYIVEDRVPLANAPTPKVVQNLNALGRMLELLQRCPLPCLSFNTACICSLIVIFLAPRTCAQSLLFPAFRLFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIETFTDIFISWLPFYYEVKVALVFWLLSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKGGGNLVQTIKRSYSLSDLSEPDMHRTQDELDDVMMSSMTSSAVVMRSTATGARLLRPRNQTPVGRSGSGTRHSTGMYFTEVDVTAKNAGDFNYNIRSQDDISSGYSSAEPVSGLSRTSSMTNASKARAKSKRNELLEEMRDEVYLDNQLYFQGVQRKSSVPEAEELKIVESSESIQSQELEKVLKEENIDAEDEAFFETLPLIEEHINEVVANYGRDEKLLPQERKHNSIEEEQFEDALFEEPQKCVSDEVDAKNIEEILTDRSQNQTPNGSAETTDSGTPSQNKPYVHPPIDPFLLVLSASASAPDPFMPERPRPMSPREMRETLEEIKHSFRAQLEAEPSVSASPSPSLRPKANHGKGRAPPPPLPPKKHSLSPQPDAISQTSTGSVERKSGQIHVC