wanglab/gogpt-training-data huggingface dataset:
Protein: Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) (PIST) (Q8BH60)
Organism: Mus musculus (Mouse)
Function: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor (By similarity). May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity).
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
Interaction partners:
- Rho-related GTP-binding protein RhoQ
- Cytokine-like 1
- Cystic fibrosis transmembrane conductance regulator
- Golgin subfamily A member 3
- Membrane cofactor protein
- PRKCA-binding protein
- Syntaxin-6
- Beclin-1
- Proto-oncogene tyrosine-protein kinase ROS
- Na
Sequence:
MSAGGPCPAGAGGGPGGSSCPVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLRSELTETQAEKVVLEKEVHEQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSVEDLERELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSGNSGASCKDSSGEMKMLQGYNKKAVRDAHENGDVGAAGESPLDDTAARAAHLHSLHQKKAY
Protein: Tir chaperone (P21244)
Organism: Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Function: Chaperone for the type III secretion of Tir. Probably stabilizes the protein, prevents inappropriate protein-proteininteractions and aids in secretion.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MSSRSELLLDRFAEKIGVGSISFNENRLCSFAIDEIYYISLSDANDEYMMIYGVCGKFPTDNPNFALEILNANLWFAENGGPYLCYESGAQSLLLALRFPLDDATPEKLENEIEVVVKSMENLYLVLHNQGITLENEHMKIEEISSSDNKHYYAGR
Protein: K+-H+ exchange-like protein (Q9C8N0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRARLVVFPIKGKKWCFSRSVDPFAAQSPSGVTPTTVRGLWKKISSESKPINANAELLVDFISDKMNKAWVGLEKAPDGSIKNKIHGFGLKLLARVKPSEIFLKSISKEVTSVQVTYPPSLDPRLVRRRLRHIAMSGTILHKKYLVGSVTLLPLTSAFMVLPLPNIPFFWVLFRTYSHWRALQGSEKLLKLISNEANPDKPDSTDDADESKNSNTKPEQKSQSPTCILLPSEELYQLIREASEEGLDEATIIEICKSFDLNKNDVLKYRNLV
Protein: Gasdermin-C2 [Cleaved into: Gasdermin-C2, N-terminal (GSDMC2-NT); Gasdermin-C2, C-terminal (GSDMC2-CT)] (Q2KHK6)
Organism: Mus musculus (Mouse)
Function: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C2, N-terminal) binds to membranes and forms pores, triggering cell death.
Subcellular location: [Gasdermin-C2]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYG8}.; SUBCELLULAR LOCATION: [Gasdermin-C2, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Interaction partners:
- Gasdermin-E
- Gasdermin-C3
- Pejvakin
Sequence:
MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPRSGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVGYVGYGGYNIEVQSTSIPNPKLEILQNRKLLDNLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLSVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSATKKKMTFPGTPKYASASEPTEIYRTELQGLWINDIVPIGRIQEPAHLDFMCLQNEVYKQTEQLAELSKGVQEVVLSSILSMLYEGDRKVLYDLMNMLELNQLGHMDGPGGKILDELRKDSSNPCVDLKDLILYLLQALMVLSDSQLNLLAQSVEMGILPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLRKANSSSKPSLRPGYI
Protein: 2'-5' oligoadenylate synthetase 1E (Q8C2W3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSPEKQ
Protein: L-Ala-D/L-Glu epimerase (AE epimerase) (AEE) (EC 5.1.1.20) (L-Hydrophobic/Polar-D/L-Glu epimerase) (A0Q5S7)
Organism: Francisella tularensis subsp. novicida (strain U112)
Function: Dipeptide epimerase with a preference for substrates containing a Glu residue in the second position. Catalyzes the epimerization of L-Ala-L-Glu, L-Ser-L-Glu, L-Thr-L-Glu, L-Val-L-Glu, L-Gly-L-Glu and L-Thr-L-Glu (in vitro). May play a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component.
Interaction partners:
Sequence:
MSKIIDIKTSIVTIPLKRTFVTAVRSTNHIDAVVVELSLDNGNKGYGVAPATTAITGDTLQGMQYIISEIFAPVILSSNLSDYKQTLELAFKKVMFNSAAKMALDLAFHDLLAKQKNISVAKLLGAKNNIIETDVSISCGSVAETIQNIQNGVEANFTTIKVKTGADFNRDIQLLKSLDNEFSKNIKFRFDANQGWNISQTKQFIEELNKYSLNVEIIEQPVKYYDISAMREITKFSNIPIVADESVFDAKDAERVIDEQACNMINIKLAKSGGILEAQKIKKLADSVGIPCMVGCMMESPAGILATASFALAEGITVADLDPLDWVAKDLYSDYITFNEPNIIIKDNLKGFGFSF
Protein: DAF-15 (Raptor N-terminal CASPase-like domain-containing protein) (Q68TI8)
Organism: Caenorhabditis elegans
Interaction partners:
- Ras-related GTP-binding protein C
- Target of rapamycin complex subunit lst8
- Target of rapamycin homolog
- GTP-binding protein
- RICTOR_N domain-containing protein
- GTP-binding protein Rheb homolog 1
- Ribosomal protein S6 kinase beta
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- Serine/threonine-protein kinase unc-51
Sequence:
MRQKVQRSALARITSSLNSLPTHKMEEDRSITPFSSFAERLTVNLWHAQRNVERVTLYLQEPRHVEDIAGSMEDEWDCIEECVNRRKGSDRLRTASVAIIMCLHLGVDPPEAPSRKDAPSRLLSWVDPYKCGAHKAAIEIGLSTQRAYEKWQPKSKTRYKICTDPPIDDVRKVATNLRRISGNDRVLFHYNGHGVPKPTDNGEIWVFNKSFTQYIPLSIFDLQGWLDYPTIYIWETHSAETILHNYRRFGEDQKISWQSRFDRWQEEQRNLPPISSKMTDADQAEALGFPEKYPRYNDCIHLAACSAGQWLPMSNPHLPADLFTSCLTTPIRTSLAFHLSHSEHRDEYPENILDMIPGNLAERRTVLGELNWIFTAITDTIAFTSIDRDSFQKLFRQDLLLATLFRSFLLAQRVMSKFNVLPVSQPPLKDTSMHDLWRCWDQTMDMVLDYCRELIYVKECERALFCGRDVINRSNVFPFLVLIDFEHVLTYNETHQYNTFFTEQLQAFELWLDYGVDEGTPPLQLPMVLQVLLSQAHRVRALRLLARFLDFGRWAIGYSLAVGIFPYVLKLLQSNISDLKISLAFIWAKILAVDPSCQMELFNECIDESATQQQSPAQSQQPSVALKPSSMFANHPPPAQLTMDKRALQINTQTGGRFQTNQNQALDMQLQYAQQQAHQRQMDPSGGQHSPNAQPRQPQPQQPQQLQQQPSQQQQQQSRQPQGIMKPTNAQPQEKKTMLRFQYFLQLLGDPEIKPKQKTVAAFVLAQLTSNNFKLAQKELTNKGYMGICTELMVDDTARSVKLLKLWILIGLGRLWSDYDVARWQGIRLMAHDKMILELSDESAEVRAAAVFALGSLLRNSSRSNEHASAVEENLAGELCSQCVFDSSVLVREELIVALQWFVFDFEKRFVKFLLELSNQIKFKLPRKRNSSENLSEQGLDIAAEMPSNHRRPRAPPVNEFMQPSVIRKKMSTSVFSTAVEETVHEDGIGNVYHIAHEAGNRVEQESEDIEYRERAKVQIKHLEAKTFNEAVAKTWLSLLILSLDPIERVARMAQKIVHRVEAGMPEMQANIDNTMAHLSRKMIARKNSKATVEMPRKPVGPSEEVSTLSERIKRNLEVEKESGVSADGIDFTKLNMQKAKEQRKGGKGGQIKKLQDESKVKFQVGSPGDVNQQHKNALSPGSSFTDETQSSELFSKDDSSDDDENKSANDEKDRATTASGKTVKGAFRKSDIMDAALMEFTPRRTKAVPGDFAVKEESKTLRTVIENPIVSTQFVAWCSKVFVEPILHVITLDEEKSEDWEHEDEDEFMPEQFREKIKDIQKQDRKMHEEKRARDKKEGKKEKSQEDVVVTTTTISDWAIHAMEGMLQSADIEGRDFQSCKYDECLWRVKLTHPARSLTTSKLRRCMYASDGRLMTIIRQDTDTRSFRRFDLTASNPFCPSYVSQLILINDMSREMVIACSTNGVVRIWDPYFLGWCDDYEKPPELVSASFPLESQMKISDETNRCLFDWNQQNGKLLCTGTRSVRIWDAHCEKVCHDVMYSPGSKQQTGPGAKLNTNTLPTAMSGNLDEEGNMVAVGYADGRVDYFDMRMANPKAARCNLAPVNMSKQFNDRPPGIMHLRVNRQGFGTELFAGSQDGSIYKLQLRMFKEATPSIVTPWEYGAHSHMFVHEDSRILASAGGGELAIYDVAQNKLMARILPPGEPNSMRRDKNSSTFGLFSSQRKLSQVQMSGRMSSMSSATVGEDRQPKVISLTMHQMRLLTVAGYDDNTVCVYGSPKPGLTGHYENTQGASSPPSQSL
Protein: Clp protease adapter protein ClpF, chloroplastic (Q67Y99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Clp protease adapter that facilitates CLPS1 recruitment to ClpC chaperones thus forming a binary adapter for selective substrate recognition and delivery to plastid Clp protease system (CLPC).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:26419670}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 5, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- Chaperone protein ClpC1, chloroplastic
- ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 4, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 6, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 3, chloroplastic
Sequence:
MVQSQSLSTLTICGSVKVSSLLRNRLNSVKASSLIGDRCVSCQFLRKSPSFRSHWKSLKQRNLLRVEARWPFQGGGEQGLDPSSERSESANEDILIFFFQLDLATRVQYAMNLEQYDIAQQLREKLTEVEEESIRLQEGKRGSSAKSEAQDKGISIIRLRADLQNAIDSEDYGLAAKLRDEISKLEAESLAVSAKALAFEKAEYAFRLGQKLRHKTFGYRAVVCGMDPICSESSSWMEAAEVEKLPRGSNQPFYQVLVDVRTHPDLLVAYVAEDNLLAPEKPDKERFDHPYISFLYYGADTAGDFIPVKQLREKYNRPRHEVPFDSQDED
Protein: RNA helicase (EC 3.6.4.13) (D6RJA6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGDAVR
Protein: Epidermal growth factor receptor pathway substrate 15 isoform B (Q5JC29)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSVSSNSSNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPNPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPAFPRQ
Protein: Ras-related protein Rab (Q8T0G8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU367128}; Lipid-anchor {ECO:0000256|RuleBase:RU367128}.
Interaction partners:
Sequence:
MATGVIQSSVVSTSAGRQNICDCLEQESAGLVKALPKSKSADQLSELTCACLRCQYLATDLQHPNTQSGHLPVEHRHRPVSSGSGSLGALSAKESPIFVRRQICFPSAETQLHPPLSSSQFSLRSASPAYAEPKPELDLGAIEALQLTTVMPAGVNRNHMDINRNNGYLHNGAIMTSTSDKREHLYKILVIGELGTGKTSFIKRYVHQFFSQNYRATIGVDFALKVLQWDANTIVRLQLWDIAGQERFGNMTRVYYKEAVGAFIVFDVTRSGTFDCVSKWKEDLDSKVQLPDGSPIPCILLANKCDQEKQGIITQPEKMDEYVRENGFAGWFETSAKENINIDEAARALVNKILINDKLISADLADGDKFNLSAADATGSDAKNKCSC
Protein: Voltage-gated inwardly rectifying potassium channel KCNH2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (MERG) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) (O35219)
Organism: Mus musculus (Mouse)
Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium voltage-gated channel subfamily E member 2
- Sodium channel protein type 5 subunit alpha
- Potassium voltage-gated channel subfamily KQT member 1
- Potassium voltage-gated channel subfamily E member 3
- Potassium voltage-gated channel subfamily E member 1
- Potassium voltage-gated channel subfamily E regulatory beta subunit 5
- Potassium channel subfamily K member 1
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Inward rectifier potassium channel 2
- Potassium voltage-gated channel subfamily E member 4
Sequence:
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESSVRTGSMHSAGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPGSASPVASIRGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDPPGGEPLTEDGEKSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSASPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS
Protein: HAUS augmin like complex subunit 7 (A6NDA1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGQDAGCGRGGDDYSEDEGDSSVSRAAVEVFGKLKDLNCPFLEGLYITEPKTIQELLCSPSEYRLEILEWMCTRVWPSLQDRFSSLKGVPTEVKIQEMTKLGHELMLCAPDDQELLKRFIHVTNGL
Protein: Odorant receptor 59b (Q9W1P8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Also plays a role in the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 85b
- Odorant receptor 56a
- Odorant receptor 47b
- Putative odorant receptor 92a
- Odorant receptor 47a
Sequence:
MAVFKLIKPAPLTEKVQSRQGNIYLYRAMWLIGWIPPKEGVLRYVYLFWTCVPFAFGVFYLPVGFIISYVQEFKNFTPGEFLTSLQVCINVYGASVKSTITYLFLWRLRKTEILLDSLDKRLANDSDRERIHNMVARCNYAFLIYSFIYCGYAGSTFLSYALSGRPPWSVYNPFIDWRDGMGSLWIQAIFEYITMSFAVLQDQLSDTYPLMFTIMFRAHMEVLKDHVRSLRMDPERSEADNYQDLVNCVLDHKTILKCCDMIRPMISRTIFVQFALIGSVLGLTLVNVFFFSNFWKGVASLLFVITILLQTFPFCYTCNMLIDDAQDLSNEIFQSNWVDAEPRYKATLVLFMHHVQQPIIFIAGGIFPISMNSNITVAKFAFSIITIVRQMNLAEQFQ
Protein: Alpha-farnesene synthase (EC 4.2.3.46) ((E,E)-alpha-farnesene synthase) (Terpene synthase 7) (RcSeTPS7) (B9RXW0)
Organism: Ricinus communis (Castor bean)
Function: Catalyzes the cyclization of farnesyl diphosphate to (E,E)-alpha-farnesene.
Interaction partners:
- Alpha-copaene synthase
- Probable terpene synthase 3
- Uncharacterized protein
- Probable terpene synthase 4
- Farnesyl-pyrophosphate synthetase, putative
- Farnesyl-pyrophosphate synthetase, putative
- Geranyl geranyl pyrophosphate synthase, putative
- Geranyl geranyl pyrophosphate synthase, putative
- Geranyl geranyl pyrophosphate synthase, putative
- Geranyl geranyl pyrophosphate synthase, putative
Sequence:
MKVGQPVLQCQTNSEAFGMMQERRSGNYKPNIWKYDFLQSLSSKYDEEKYKTQAERLKEDAKHLFIEAVDLQGKLELVDCIIKVGLASHFKDEIKKALDTIASSIKNDKSDAIKNRYVTALCFRLLRQHGYEVSQAKKSDFLDENGTFLKAKSMDVKGVLELFEASYLALESENILDDAKAFSTTILKDINSATTESNLYKQVVHALELPFHWRVRWFDVKWHIKTFQKDKSINKTLLDLAKVNFNVVQATLQNDLKEISRWWRNLGLIENLKFSRDRLVESFLCTVGLVFEPQYSSFRRWLTKVVIMILVIDDVYDIYGSLEELQHFTNAINRWDTAELEQLPEYMKICFKTLHTITGETAHEMQREKRWDQEQTETHLKKVWADFCRALFVEAKWFNKGYTPSVQEYLKTACISSSGSLLSVHSFFLIMNEGTREMLHFLEKNQEMFYNISLIIRLCNDLGTSVAEQERGDAASSIVCHMREMEVLEEEARSYLKGIIGNYWKKVNEKCFTQSPEMQLFININVNMARVVHNLYQNRDGFGVQDHQNKKQILSLLVHPFKLD
Protein: BRCA1 interacting helicase 1 (A0A0G2K475)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Breast cancer type 1 susceptibility protein homolog
- DNA topoisomerase 2-binding protein 1
- DNA mismatch repair protein Mlh1
- BRCA1-associated RING domain protein 1
- Breast cancer type 2 susceptibility protein homolog
- Nibrin
- Partner and localizer of BRCA2
- Mismatch repair endonuclease PMS2
- Double-strand break repair protein MRE11
- DNA repair protein RAD51 homolog 3
Sequence:
MSSVLSEYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLTGKPVDEGLNKKPEAPSSCSCSCHSKNFTYSDTNLDTSPHFSSPSKPSSERNAVSSPCRDSPERNSLAAKLSAKKHASIHEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHLDARLASEKRVKPESPIRKTSSSFQNPDGLCSRCCCSANQGINKESANTVKKDNGDQSKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKHGKSCYFYHGVHRISNQQTLQFLHGISKAWDIEELVSLGRKLKACPYYTARELIDSADIIFCPYNYLLDSQIRESMDIKLKEQVVILDEAHNIEECARETASYSVTEVQLRFARDELDSLINSNIRKKSHEPLRDVCYNLINWLETNSKNLVERDYESSCKIWSGNEMLLNLHRMGITAASFPVLQKHLSAVLQKEEKVTSTHGKEEAIQIPIISASTQIMLKGLFMVLDYLFRKNSRFADDYKVAIQQTYSWTNQIAIFDKNALLPVPKNKKHSRQKIGVNVLNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFNIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPDRYISGLSKWVRQQIQHHSTFASALESLTEFSKRHQKVTNRSKKEEKCTKENGSTLDVACLEGSTLTSVSEASHQTPENSLEEEAKVCVQEQRYPQMAAENPSGPSHGVSRRKESDPGLREKSVQTMKTEKSEISRSSSPTFGKQTEPVNWPIFNSLKRHFNSKVKNRTPVLKSSKNHASASSAFNKTALPLTGKCVSSSAPANTPLAPCPQSEVIIPSVKADTTPAKTHCKQNEKDPSPDAELSPVTEEAKGSSSNPAVGTEVDDDSVCFTPELFDPVSTDEENSELVETDRSSNNSDCLSAEELFETVTGFGQK
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q57VP1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSHEFSGSGEEYLARFRFNWLMEEWTEEVARVRPTDPFSYLLGLIQAYRGGEDNFVTCKNDWCRAFVPQSQRGAHLLKCATDVQLVQCPNCRLRIKESDYRQHKQKCLLHQCVYCGERVPARLIECCPSKVRMNNEISSRARSSPNIGKGNKHASTEGAATSHHEKLWDEPPLAPFSKFSRIKLDFPERNRNPLTRLQRMWRSASIYERMLDTAFKQVWNGIEFRRVSRGPPELGGCISTRSRSHSPRQRPSSPNTAEPADYSITMEEYVDISESILSGGVVCFKIAVRILTNAIAIMSKRSAVLRVNIPDGGDAVVVGDLHGQLKDLALVLNRLCGLPSPRRYYVFNGDYVDRGSNGVGVLLHVLLLQCLFPDYVFINRGNHEDSRVNAEYGFQAEVFSKYTYWEAKQLLDLFSASYDVMAWATLVDEDVIVVHGGVPRNGATVAEIEAVGRVTKFSALEPRTDGERLASELLWNDPVDTYLSRRIGVRHQGANWRSSVRGVGVEYLEPITENFLRLNKLKLVVRSHQMVQAGFQFVHGRSNCTVFSASNYTGVSNNRGAIAVLEKGSVQPTFHTWFLRDAETVVRDVVMSDLLEGLTDFSRGVDAEESPVGQDGNGSGDTKAMGGVSSVKDGESPSHHESPRAKTVDSSRKAGPVHSPIELVRCVDDTRERMLARARMLDVLVGIIYSSRYSLLSSFVRADSGKNGTIHKVEWCDIMRKVLNMDIPWYFLAPYLVGSSYEEGSPYIRYVTFLRRFNPCFTSLFSARFQTALLRHVFRDVDMPGDLLSCITTDHFAEEQPITDDNGKFIGSGVTLSPSGLMLNLAERTGDGCRGIPNTMGGSSVLPSGGCCGGGNQRDDSWRKIRLSFNSLVSALRSISRAGGMMEDNTIFTLFQIFDKDACGHAAVGDIVDVVDSVGVEDSDESVVLDLTGSFDIDFFPQRGSDEKPAAGTTVLCDEPSGVSADAVIPMPSPVSKAGEYCDDWTPANSASSTALASYTPAHVEMAVDSDEESSTHSSSVLWSRQSVSATMSDLDCMRVYPVLLHLHERFACDTIRSTLQHFKALNNTHDGKLTFDQFAVTFNHIGRCMLDPPTRQEQQIIFCLIRDVGQHLLGSAECCSLSESLGVLSRALSRASSLRCQVALLKSVVNNIGVKNAQADYLTRDQFVTFFSTVSISHGEHSCHYDDHVAESGCKEWTTNFGESGSCNSGDTSKVGALKLCPLWCLDQCVPSEDTAAVATAVGSADAETRAERPSAVPPVQADGREDAFARREGRRRRRLPRTMLPRCAKQERLPISCVARSPHAAPSRFNSEQQSPLLRYRSEQQSPLPRIGSEQQSPLHRRALRSCRGHLNRDRARQRTGFSSPLSSDHTSGSVREGSPSPIPPQAPYGEMVPTSESLAANATGRSTCRDNFSLSSTLLGGDGDHSG
Protein: Regulator of G-protein signaling egl-10 (Egg-laying defective protein 10) (P49809)
Organism: Caenorhabditis elegans
Function: Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. Plays a role in regulating dopamine-mediated locomotion behavior.
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:8548815}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-2
- Regulator of G-protein signaling rgs-11
- Guanine nucleotide-binding protein subunit beta-1
- Regulator of G-protein signaling rgs-6
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha
- Dopamine receptor 3
- Guanine nucleotide-binding protein alpha-16 subunit
- Chaperone ric-8
- T-complex protein 1 subunit epsilon
Sequence:
MALPRLRVNASNEERLVHPNHMVYRKMEMLVNQMLDAEAGVPIKTVKSFLSKVPSVFTGQDLIGWIMKNLEMTDLSDALHLAHLIASHGYLFQIDDHVLTVKNDGTFYRFQTPYFWPSNCWDPENTDYAVYLCKRTMQNKAHLELEDFEAENLAKLQKMFSRKWEFVFMQAEAQYKVDKKRDRQERQILDSQERAFWDVHRPVPGCVNTTEVDFRKLSRSGRPKYSSGGHAALAASTSGIGCTQYSQSVAAAHASLPSTSNGSATSPRKNDQEPSTSSGGESPSTSSAAAGTATTSAPSTSTPPVTTITATINAGSFRNNYYTRPGLRRCTQVQDTLKLEIVQLNSRLSKNVLRTSKVVENYLAYYEQRRVFDPLLTPPGSQADPFQSQPNPWINDTVDFWQHDKITGDIQTRRLKLWEDSFEELLADSLGRETLQKFLDKEYSGENLRFWWEVQKLRKCSSRMVPVMVTEIYNEFIDTNAATSPVNVDCKVMEVTEDNLKNPNRWSFDEAADHIYCLMKNDSYQRFLRSEIYKDLVLQSRKKVSLNCSFSIFAS
Protein: Regulatory protein zeste (Q9W1M6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTMANGAVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS
Protein: Akirin-2 (B1AXD8)
Organism: Mus musculus (Mouse)
Function: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development. Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development.
Subcellular location: Nucleus {ECO:0000269|PubMed:25107474, ECO:0000269|PubMed:30116001, ECO:0000269|PubMed:30801883}. Cytoplasm {ECO:0000269|PubMed:30801883}. Membrane {ECO:0000269|PubMed:30801883}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000269|PubMed:30801883}.
Interaction partners:
- NF-kappa-B inhibitor zeta
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-4
- Proteasome subunit beta type-3
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-7
- DNA methyltransferase 1-associated protein 1
Sequence:
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQADPGCTSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS