wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13) (Q16696)
Organism: Homo sapiens (Human)
Function: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 3A4)
- Cytochrome P450 3A5
- Cytochrome P450 1A2
- UDP-glucuronosyltransferase 2B17
- UDP-glucuronosyltransferase 1A7
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A9
- UDP-glucuronosyltransferase 2B7
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase 1A8
Sequence:
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR
Protein: Transcription factor AP-2-alpha (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (O13111)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLWKLTDNIKYEECEERHDSASNGTARLPQLGAVGQSPYSSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNSLHTQPQPQHPAWPGQRQSQEPSLLHAHRGLPHQLGGLDPRRDYRRHDDLLHGPHGLGAGLADLPLHSIPHAIEDVPHVDDPGINIPDQTVIKKGPVSLSKSNNNAVSSIPINKDALFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSTKSSDKEEKHRK
Protein: Transmembrane protein (Q38BJ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPYFFKPLGARAWGFIAASVGGTFAIGIFREIALLRQREIPLFNEADVVHSEEHARYPCKTFLGYDVVVTNHYVREKGRGEQSLLPRGSDAENGNCGRSDRGGVMKKLFACFSNETYTTAGHSDSVSEVNELYLVREVVGDAHAPRGDVSTRSVKGFNGDDDDAVEDTVGNRVGSSMFIASSSWPPGTVKYTSMTIETSHNEVRNDSDALLRRWSNRVTQQSLVRCDPLAPASMNCLADASYLGAPYLRIMLSALLLLPSPLPRLRVAVLGVGGGFSPSFIAAAFLT
Protein: DNA excision repair protein ckn1 (Q9USR0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA repair protein rhp26
- DNA damage-binding protein 1
- Cullin-4
- Chromatin modification-related protein rik1
- DNA repair protein rhp7
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerase II subunit RPB9
- RING-box protein pip1
- WD repeat-containing protein 21
- ATP-dependent helicase rhp16
Sequence:
MNSFLLAREWGQEPNSSFRRQLLQHRLQRLALNPDVKIKRRHGAGILGSVNALSIDNTIHQLMVSGGANSSINVWDLQNIDQKEDEDLILDTLNAVPARTSHKFGITDLHWFPFDNGIFTSSSFDHTLKVWDVSTLQEAYTFTMEDMIYSHAWSPIASHCLIATAYRSSSIRLCDMQSGSYTHSLSGHTGNVLAVDWCPKNEFVLASGSADGTCRLWDIRKVSSSFACMDLHNKYLPSNQTNISHYGTVNGLAWTSDARYLASCGTDDRIRVWNMESGRNTLREFGPIIHNQTTSFAVHPCMIQPSMDSDVFVLFPNDDGSLALLNLLEGSFVRRLSTHSLKRINCAAYRPDFEQCFTGDMNGNIYMWSPKALKSPTKISDLETRRNIIQEVYDSLINIPVTYQ
Protein: Lividin-4 (Q2UXR1)
Organism: Odorrana livida (Green mountain frog) (Polypedates lividus)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000255, ECO:0000269|PubMed:16713657}.
Interaction partners:
Sequence:
MFTMKKSLLVLFFLGTISLSLCVEERDADEEDNGEVEEVKRGVFTLIKGATQLIGKTLGKELGKTGLELMACKITNQC
Protein: PH domain and leucine rich repeat protein phosphatase 2 (D4A254)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
- PH domain leucine-rich repeat protein phosphatase 1
- ubiquitinyl hydrolase 1
- Adenylyl cyclase-associated protein 1
- Adenylyl cyclase-associated protein 2
- Protein SGT1 homolog
- Ubiquitin carboxyl-terminal hydrolase 46
Sequence:
MGEVEPVPAGSLEPPEPPEAAAPRRPGGIRVLKRNMKHNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTSSSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNVLTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLKAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPETLPATLQDLDLTGNTNLVLEHKTLDMFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQHSTSDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPTSSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVGSTASDEHNTVGLETSLLPRPERRCSLHPVPSAGTFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGRESENSPTLPKNSSYPCSEEHARGLGFGIRRQNSVNSGILLPVNKDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVPRDLEDEVKEQMKQHQESRPEPEPREEDRTEPLQEFDTAL
Protein: Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (E9PMG4)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}.
Interaction partners:
Sequence:
MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAGSAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANGPELGSGKAMEDTSGEPAAEDEGDTAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATASGQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGTEGGVGELI
Protein: GTP-binding protein rho5 (Q9HE04)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Protein kinase C-like 1
- Rho1 guanine nucleotide exchange factor 2
- Rho1 guanine nucleotide exchange factor 1
- GTP-binding protein rho1
- Cell division control protein 12
- Formin-3
- Cell fusion protein fus1
- Probable Rho-type GTPase-activating protein 3
- Probable Rho-type GTPase-activating protein 4
- Rho guanine nucleotide exchange factor gef2
Sequence:
MTTELRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGRHIELALWDTAGQEDYDRLRPLSYPDSHVVLICFSVDAPESLDNVQEKWISEVLHFCSNLPILLVGCKVDLRNDPKTIEELSKTSQKPITFEEGQVVAQKIGAYKYLECSAKLNEGVNEVFETAARASMLKFKPASVPKTKKKKHCILL
Protein: Twisted gastrulation protein homolog 1 (Q9EP52)
Organism: Mus musculus (Mouse)
Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Chordin
- BMP-binding endothelial regulator protein
- Bone morphogenetic protein 4
- Growth/differentiation factor 15
Sequence:
MKSHYIVLALASLTFLLCLPVSQSCNKALCASDVSKCLIQELCQCRPGEGNCPCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQLHHQNVSVPSNNVHAPFPSDKERMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF
Protein: Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) (P9WHU7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01925}.
Interaction partners:
- proline dehydrogenase
- L-glutamate gamma-semialdehyde dehydrogenase
- Glutamate 5-kinase
- Gamma-glutamyl phosphate reductase
- prolyl aminopeptidase
- Uncharacterized protein Rv0499
- Anthranilate phosphoribosyltransferase
- Uncharacterized protein Rv0498
- Exopolyphosphatase 1
- Uncharacterized protein Rv0497
Sequence:
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
Protein: Mitochondrial rRNA methyltransferase 1 (A0A087WZC1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQSSEIPIMSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLPPGLESLNVSVAAGILLHSICSQRKGFPTEGERRQLLQDPQEPSARSEGLSMAQHPGLSSGPEKERQNEG
Protein: THO complex subunit 5B (THO complex subunit 5) (AtTHO5) (F4K4J0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- THO complex subunit 7B
- THO complex subunit 7A
- THO complex subunit 2
- THO complex subunit 3
- THO complex subunit 1
- THO complex subunit 6
- THO complex subunit 4D
- THO complex subunit 4A
- THO complex subunit 4C
- THO complex subunit 4B
Sequence:
MEDGEIEEGMVTADEFPTPEVTTIETIQPPREPGKSPLELLRESKTSVEEIVAKMLSMKKQGNHKSEIRELLTQMFLNFVNLRQANRAILTEEDKVKAETERAKAPVDFTTLQLHNLMYEKSHYVKAIKACRDFKSKYPDIDLVPEQDFFRHAPEAIKDQSLSSDSSHVLMPKRLNFELHQRKELCKHRARLEQQKKSLLETIAERKKFLSSLPLHLKSLKKASLPVQNHLGIQHTKKLKQHNLAELLPPPLYVLYSQLLAQKEAFEESIELEVVGSLKDAQAYARQQSRKDSGMSSNTESSRLEDDGPDDDDDGQRRRKRPKKLTSKEGSDKAGLYQVHPLKIVLHIYDDEIPDTKSLKLVILKFEYLLKLNVVCVGAEGSQDGPEKNIFCNLFPDDAGLEPPHQSTKLILGDGQTFDENRTSRPYKWVQHLAGIDISPVLLGQEAHNTDPAKSDTFVPDLSLYRQQHRVQTVLRRIRLRKKAHLALAEQLDLLMKHELPVVNCEDAPWALHKVLCALDSWLHIQSSASKSCSLTLNSVEQVPEPMEIDVDGRSISGKEDFESIREDGELPSLVTAAASLTSSNHTPSKVSNQARSRQLALMTKNLDSPISKGKSPSFKKYEDDLDLVLDDDSEIDEPTGRTEAHVEELCPEKADNSWVDYGSREFALVFSRKTDGGKLWKLEAMVQISMEYPLRPPLFSLSLHASSSSGNENGTNESDHYNELRAMEAEVNLHMLKIIPSDQENYLLSHQIRCLAMLFDYYVDDPSPDSKRGTATTVVDVGLCKPVDGKLLVRSFRGRDHRKMISWKGRGCASGYPC
Protein: TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) (Q8TC07)
Organism: Homo sapiens (Human)
Function: Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Mitochondrial fission 1 protein
- TBC1 domain family member 17
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Ras-related protein Rab-7a
- Gamma-aminobutyric acid receptor-associated protein
- Ras-related protein Rab-7b
- TBC1 domain family member 5
- Ras-related protein Rab-4A
- Ras-related protein Rab-11A
Sequence:
MAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA
Protein: mRNA decay activator protein ZFP36L2-A (CCCH zinc finger protein 3-A) (XC3H-3) (Zinc finger protein 36, C3H1 type-like 2-A) (Q7ZXW9)
Organism: Xenopus laevis (African clawed frog)
Function: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs. Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail. Required for tubulogenesis during pronephros development (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P23949}. Cytoplasm {ECO:0000250|UniProtKB:P23949}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. {ECO:0000250|UniProtKB:P23949}.
Interaction partners:
Sequence:
MSATLLSAFYDIDLLYKNEKALNNLALSTMLDKKAVGSPVSSTNSNLFPGFLRRHSASNLQALSGSTNPAKFCHNNNNNQLNESAASSTALLNRENKFRDRSFSENGERSQHLLHLQQQQQKAGAQVNSTRYKTELCRPFEESGACKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRQAPGAGERPKLHHSLSFSGFPNHSLDSAPLLESPTSRTPPPQSSGSLYCQELLQLNNNNPCANNAFTFSGQELGLITPLAIHTQNSSYFRQPSSSPPLSFQPLRKVSESPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSDSPTLDSNRRLPIFSRLSISDD
Protein: Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) (P32756)
Organism: Caenorhabditis elegans
Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.
Interaction partners:
- Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1
- Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 2
- Vesicular acetylcholine transporter unc-17
- Choline kinase A2
- Choline kinase B2
- Choline kinase B1
- Putative choline kinase B3
- MaoC-like domain-containing protein
- High-affinity choline transporter 1
- Bifunctional glyoxylate cycle protein
Sequence:
MEKEKVDELPPNDNWYETALPKPPVPSLEATLDRYLEYAAVVAVGQKASLATTHDAAHKFVRQATPLQEQLLEIAEKSPNWATKFWLPEMYMRVRMPTPVNSNPGYIFPKVKFETKEDHIKYTALLTRGLLEYKNLIDTKQVCREKSTGAQKLQMCMEQYDRVLSCYREPGVGEDTQIRKQKTNDGNEHVLVMCRNQTFLLHSRINGALVSYADVEYQLAQIEEISKINQNNTANIGASGVGPRDNAALFWQDMLTVEQNSKSYEWVKSALFVVCLDMEDPIDYGKNDTMSISEKEKEFVARGYSTLTGHGSSKFGLNRWYDATIQLVVSSSGVNGLCIEHSTAEGIVIINMAETAIRYAQKYFKSKMVWNDVRNVHPKSLTWHFSENSRNILKKQAEVFDELANELELEVLIFNEFGKDSIKNWRVSPDGFIQLIMQLAHYKTHGHLVSTYESASVRRFGAGRVDNIRANTQEALEWVTAMASKKESKERKLELFKKAVLKQVKVTLENISGYGVDNHLCALFCLAREREETTGEDIPSLFLDPLWSEVMRFPLSTSQVTTSLDIPDCYLTYGAVVRDGYGCPYNIQPDRVIFAPTAFRSDPRTDLQHFKKSLAGAMRDVKELLSN
Protein: Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) (Q9BU02)
Organism: Homo sapiens (Human)
Function: Hydrolase highly specific for thiamine triphosphate (ThTP).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11827967}.
Interaction partners:
- Thiamine pyrophosphokinase 1
- Cancer-related nucleoside-triphosphatase
Sequence:
MAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVASFVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG
Protein: GH04717p (Q8IH70)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
KFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLEKMKPLNASDPIIGSIISLDKLFEEKLSGAEPSTAFVGGGGELIIPTDILRHSRNDSRTMHMDYCYDKCGRVVTPANTCNQPQTKSKKHFRSASCDVKMIKSFARDHSSSSGPADAAGQDAVGASTKYKNLKKFQAHTRNHSTDLHDPSQPIRYIQNQLRPQDCPEEDDDEELTTGCGHFVKKHSRNHSYDQIYMPNNIRFDADFLRHPHSHHNPKKNVNVLKNVVSDVGKLKNSNEIEAGGAGSRGHSRNNSKDLNTKISSATPASGQVVTDASTTGLSVLRHRRTNSKDLNYQVLPESAASSSVSGHAHPQHTRNTSHHKIQIDDDRNELINDNDDEEEERSACA
Protein: Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Q5ZLN1)
Organism: Gallus gallus (Chicken)
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.
Interaction partners:
- Phosphoglycerate kinase
- Triosephosphate isomerase
- Alpha-enolase
- Gamma-enolase
- Glucose-6-phosphate isomerase
- Enolase 4
- Fructose-bisphosphate aldolase C
- Fructose-bisphosphate aldolase B
- Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.
- Glycerate kinase
Sequence:
MAAYRLVLVRHGESAWNLENRFCGWYDADLSPAGQQEARRGGEALRDAGYEFDICFTSVQKRAIRTLWNVLDAIDQMWLPVVRTWRLNERHYGALTGLNKAETAAKHGEAQVKIWRRSFDIPPPPMQSDHPFFSTISKDRRYADLTEDQLPTCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGMSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK
Protein: Protein Wnt-8a (P51028)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for mesoderm and neural ectoderm patterning during gastrulation. Involved in axis formation during embryonic development, via activation of canonical Wnt/CTNNB1 signaling. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9H1J5}. Secreted {ECO:0000250|UniProtKB:Q9H1J5}.
Interaction partners:
- Low density lipoprotein receptor-related protein 5
- Catenin beta-1
- Frizzled class receptor 2
- Frizzled-5
- Frizzled 8a protein
- Axin-1
- Secreted frizzled-related protein 1
- Secreted frizzled-related protein 5.
- Low density lipoprotein receptor-related protein 6.
- Protein wntless homolog
Sequence:
MNPCQIFASLVMSICCHILSSTAWSVNNFLMTGPKAYLAYTSSVQAGAQSGIEECKHQFAWDRWNCPESALQLSTHKGLRSATRETAFVHAISAAGVMYTLTKNCSMGDFENCGCDDSKIGKMGGRGWVWGGCSDNVNFGDRIAKLFVDALENGHDSRAAVNLHNNEAGRLAVKATLKRTCKCHGLSGSCSIQTCWMQLADFRDIGSYLKIKHDQARKLEMDKIRMRAGNSADNRGAIADTFSAVARTELIFMEDSPDYCVKNLSMGLHGTEGRECLQSGKNLSQWERRSCRRLCHECGLKVEERRIETVSSCNCKFHWCCTVKCETCTQTVTRYFCAKRHRNRRPHNHSRKRQHTRRG
Protein: P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) (Q62170)
Organism: Mus musculus (Mouse)
Function: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- E-selectin
- P-selectin
- L-selectin
- Intercellular adhesion molecule 1
- Vascular cell adhesion protein 1
- CD40 ligand
- Integrin beta-2
- Radixin
- Lysosome membrane protein 2
- Tissue factor
Sequence:
MSPSFLVLLTILGPGNSLQLQDPWGHETKEAPGPVHLRERRQVVGDDDFEDPDYTYNTDPPELLKNVTNTVAAHPELPTTVVMLERDSTSAGTSERATEKIATTDPTAPGTGGTAVGMLSTDSATQWSLTSVETVQPASTEVETSQPAPMEAETSQPAPMEAETSQPAPMEAETSQPAPMEADTSQPAPMEAETSQPAPNEAETSKPAPTEAETSKPAPTEAETTQLPRIQAVKTLFTTSAATEVPSTEPTTMETASTESNESTIFLGPSVTHLPDSGLKKGLIVTPGNSPAPTLPGSSDLIPVKQCLLIILILASLATIFLVCTVVLAVRLSRKTHMYPVRNYSPTEMICISSLLPEGGDGAPVTANGGLPKVQDLKTEPSGDRDGDDLTLHSFLP
Protein: Gamete antigen 27/25 (Q8IEU2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MSKVQKDSAKPLDKFGNIYDYHYEHETHAPLSPRIRKVGDIEFHACSDYIYLLMTLSKDPEKFNYALKDRVSIRRYVRKNQNRYNYFLIEERVQDNIVNRISDRLISYCTDKEVTEDYIKKIDDYLWVEQRVIEEVSINVDHAREVKEKKRIMNDKKLIRMLFDTYEYVKDVKFTDDQYKDAAARISQFLIDVVDSYIIKPIPALPVTPDEPHHNNI
Protein: Ubiquitin thioesterase otubain-like (EC 3.4.19.12) (Deubiquitinating enzyme otubain-like) (Ubiquitin-specific-processing protease otubain-like) (Q9XVR6)
Organism: Caenorhabditis elegans
Function: Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 13
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-conjugating enzyme E2 2
- Polyubiquitin-A
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein
- Uncharacterized protein F34H10.1
Sequence:
MANEPQKSDDNGQAAEAVVTDDEIVLQDQQLKTIEDEQKSVPLVATLAPFSILCAEYDNETSAAFLSKATELSEVYGEIRYIRGDGNCFYRAILVGLIEIMLKDRARLEKFIASSRDWTRTLVELGFPDWTCTDFCDFFIEFLEKIHSGVHTEEAVYTILNDDGSANYILMFFRLITSAFLKQNSEEYAPFIDEGMTVAQYCEQEIEPMWKDADHLAINSLIKAAGTRVRIEYMDRTAAPNGGWHYDIPSDDQQIAPEITLLYRPGHYDVIYKKDSTEASEIEN
Protein: Sec-independent protein translocase protein TatA (P69428)
Organism: Escherichia coli (strain K12)
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00236, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00236, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}; Cytoplasmic side {ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}. Note=Abundant all over the membrane, but is more concentrated at the cell poles.
Interaction partners:
- Sec-independent protein translocase protein TatB
- Sec-independent protein translocase protein TatC
- Rhomboid protease GlpG
- 3'-5' ssDNA/RNA exonuclease TatD
- Cell division protein FtsP
- GMP synthase
- Sec-independent protein translocase protein TatE
- Trimethylamine-N-oxide reductase 1
- Flagellar regulator flk
- Membrane protein insertase YidC
Sequence:
MGGISIWQLLIIAVIVVLLFGTKKLGSIGSDLGASIKGFKKAMSDDEPKQDKTSQDADFTAKTIADKQADTNQEQAKTEDAKRHDKEQV
Protein: NTF2-related export protein (A8MS55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU369002}. Nucleus {ECO:0000256|RuleBase:RU369002}.
Interaction partners:
Sequence:
MSQMDPDAVSKAFVEHYYSTFDTNRVGLAGLYQEASMLTFEGQKIQGVQSIVAKLTSLPFQQCKHHISTVDCQPSGPASGMLVFVSGNLQLAGEEHALKFSQMFHLMPTPQGSFYVFNDIFSWRLLQVFNNLFT