wanglab/gogpt-training-data huggingface dataset:
Protein: Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) (P25500)
Organism: Bos taurus (Bovine)
Function: Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.
Subcellular location: Nucleus {ECO:0000269|PubMed:17172643}.
Interaction partners:
- U1 small nuclear ribonucleoprotein 70 kDa
- Polyadenylate-binding protein 2
- Symplekin
- Cleavage and polyadenylation specificity factor subunit 3
- pre-mRNA 3' end processing protein WDR33
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage stimulation factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 4
- polynucleotide adenylyltransferase
Sequence:
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCLLTQKLVETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPSHVLQKKKKHSTEGVKLTPLNDSSLDLSMDSDNSMSVPSPTSAMKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSLPQINSSESSGGTSSESIPQTATQPAISSPPKPTVSRVVSSTRLVNPPPRPSGNAAAKIPNPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTETKEQLDTETSTTQSETIQTATSLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
Protein: Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) (P20595)
Organism: Rattus norvegicus (Rat)
Function: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P16068}.
Interaction partners:
- Guanylate cyclase soluble subunit alpha-1
- Guanylate cyclase soluble subunit alpha-2
- cGMP-dependent protein kinase 2
- Nitric oxide synthase 1
- Inosine triphosphate pyrophosphatase
- cGMP-specific 3',5'-cyclic phosphodiesterase
- Phosphodiesterase
- cGMP-dependent 3',5'-cyclic phosphodiesterase
- Phosphodiesterase
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Sequence:
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRSEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQDSRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETNQDEN
Protein: Putative sulfur carrier protein TsuB (Thiosulfate uptake protein B) (P33014)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Thiosulfate transporter TsuA
- Putative sulfur carrier protein YedF
- L-cystine transporter TcyP
- Sulfite reductase flavoprotein alpha-component
- Sulfate adenylyltransferase subunit 2
- Sulfate adenylyltransferase subunit 1
- Sulfate/thiosulfate import ATP-binding protein CysA
- Cysteine synthase A
- Adenylyl-sulfate kinase
- Thiosulfate-binding protein
Sequence:
MVIKKLDVVTQVCPFPLIEAKAALAEMVSGDELVIEFDCTQATEAIPQWAAEEGHAITDYQQIGDAAWSITVQKA
Protein: Sabinene synthase 1, chloroplastic (Sp-SabS1) (EC 4.2.3.-) (Myrcene synthase) (EC 4.2.3.15) (A6XH06)
Organism: Salvia pomifera (Apple sage)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products, components of the chemical defense arsenal. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into sabinene, and, as minor products, myrcene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MPLNSLHNLERKPSKAWSTSCTAPAARLQASFSLQQEEPRQIRRSGDYQPSLWDFNYIQSLNTPYKEQRYVNRQAELIMQVRMLLKVKMEAIQQLELIDDLQYLGLSYFFPDEIKQILSSIHNEHRYFHNNDLYLTALGFRILRQHGFNVSEDVFDCFKTEKCSDFNANLAQDTKGMLQLYEASFLLREGEDTLELARRFSTRSLREKLDEDGDEIDEDLSSWIRHSLDLPLHWRIQGLEARWFLDAYARRPDMNPLIFKLAKLNFNIVQATYQEELKDVSRWWNSSCLAEKLPFVRDRIVECFFWAIGAFEPHQYSYQRKMAAIIITFVTIIDDVYDVYGTLEELELFTDMIRRWDNISISQLPYYMQVCYLALYNFVSERAYDILKDQHFNSIPYLQRSWVSLVEGYLKEAYWYYNGYKPSLEEYLNNAKISISAPTIISQLYFTLANSTDETVIESLYEYHNILYLSGTILRLADDLGTSQHELERGDVPKAIQCYMKDTNASEREAVEHVKFLIRETWKEMNTVTTASDCPFTDDLVAVATNLARAAQFIYLDGDGHGVQHSEIHQQMGGLLFQPYV
Protein: Galectin (E1JHQ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCLRVLYEKMMCCCPKLKKGGLNEASFYEYADAVPKYFNDQIGKLSEGISFTVTGNLSVNCERFSINLVYNNDSRDVALHINPRLPQNYIVRNTKVQDIWGNEEVSSALPFLLSRGEEFSIQVLVTEACYMISVNGQHFAAYTHRIPYRDVRILEVKGDVSNVEMKRTLVLKYPERLPQSEANNIELHIDDGINEIDASVEETVKIPHEWCIISAPNTQSDSSPKRNNSSNDLGLTLPYYGALPPNSLVDGRCLKIEGRVRLLPHSFYINLQQGQDIWPHPVIAFHLNPRFSKASSGAIGKAVVCRNAWLNGAWAQEERSEFDTNFRPGRSFCLAIVCTKTSFEVYVNRQFMTDFKYKVSPEVVDTVYIQGDVKLWNVTLEKNQMIKGKNMRVYQNPWFFSE
Protein: Truncated p53 splice variant isoform (Q2XVY6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLHKSASFSLTFNQNTSIVSRSNSRTIFEAFKEFLDFWDIGNEVSAESAVRVSSNGAFNLPQSFGNESNEYAHLATPVDPAYGGNNTNNMMQFTNNLEILANNNSDGNNKINACNKFVCHKG
Protein: Probable 2' cyclic ADP-D-ribose synthase BdTIR (Probable 2'cADPR synthase AbTIR) (EC 3.2.2.-) (NAD(+) hydrolase TIR) (EC 3.2.2.6) (NADP(+) hydrolase TIR) (EC 3.2.2.-) (TIR-only protein) (BdTIR) (I1GTC2)
Organism: Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Function: Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. v-cADPR activates ThsA, an NAD(+) hydrolase in B.cereus.
Interaction partners:
Sequence:
MASSGLSSRRSIMASRLTASAEAVNEPRRGAVVSRRVEYDEESLAGAGGESRYEVFINHRGVDTKRTVARLLYDRLAQAGLRGFLDNMSMRPGDRLEERIGSAIRECTVAVAIFSPSYCDSEYCLRELAMLVESRKAIIPIFYDIKPSDLLLPQAVADSEVYLPRDLERFKFALREAKHTVGITYDSATGDMAELVSAAADAVMYNMEKMETVQRRETMILSRL
Protein: HDA1 complex subunit 2 (A0A1D8PJR4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Histone deacetylase HDA1
- Uncharacterized protein
- Histone deacetylase
Sequence:
MNLIDMLSKDPPSSLYNPELEENIQNNEISNGISISESQDNIILDNNSNGNINNNNNNDINININNSNPPSIIYLPTPLTELQKSFVEMTLHLFSSELLNEVRSKRLKTSIDNLLDSSTTIEESDIIVNQNKISLCFEQLSIICDHPSLLIEHFIPKKMLLSETNERQLNLSGKLELFNRIIDTLIEQKPPNGYRIIVVSDNVKELELVEGIIVGKTLYYINSTNAKLFESTHFVPDLKDKSSDKVFINLLTTQQLSSNYVSDKDGECYDLIFSFDPNLDVQTPSIEILQRENGNQCPILVPIPVFTLEHIALQLPQPQQVDLMESIDAALNKWRVKCINTLVVNFFNLDEMSNDFFTENYGLNMKEFWNMMHNNRQGLNKLLDNYNGQLVLSFSEEKLIKKLNSFYNRGGNGGFDQVRDANCQLFKSKLAEAVYQKFMDLDEGVDEIELNLNGKREYETARELQYDDDEDYIANNYKKFRRLNDDANMSERKLARVDTDLLKQKQKLVFLKNKLEHLVDIADKEITDAEATSQTQSSKTLQQEVENLKKEFNRINVECEGTREKYQSSSSVALQLSHRLTQLKQQNEKIERKLFGPGMAQLPELIKKDALLSYELKLKHLEKKNEFMQQFFSSKIEMTYQERQQLLENSGSGANNRQNNRISRGATPL
Protein: Glycine cleavage system H protein (Octanoyl/lipoyl carrier protein) (O32174)
Organism: Bacillus subtilis (strain 168)
Function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Interaction partners:
- Aminomethyltransferase
- Probable glycine dehydrogenase
- Probable glycine dehydrogenase
- Octanoyltransferase LipM
- Lipoyl synthase
- Dihydrolipoyl dehydrogenase
- Dihydrolipoyl dehydrogenase
- Lipoate-protein ligase LplJ
- Dihydrolipoyl dehydrogenase
- Serine hydroxymethyltransferase
Sequence:
MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELPEVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIVVEPSDASEIEKLMTAEQYEEMTQED
Protein: Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Muscle Y-box protein YB2) (RYB-A) (Y-box-binding protein A) (Q62764)
Organism: Rattus norvegicus (Rat)
Function: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Decorin
- Tight junction protein ZO-1
- G1/S-specific cyclin-D1
- Cyclin-dependent kinase 4
- Symplekin
- Y-box-binding protein 1
- Y box binding protein 1, pseudogene 20
Sequence:
MSEAGEATTGGTTLPQAAADAPAAAPPDPAPKSPAASGAPQAPAPAALLAGSPGGDAAPGPAPASSAPAGSEDAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNYAGEEEEEGSGSSEGFEPPAADGQFSGARNQLRRPQYRPPYRQRRFPPYHVGQTFDRRSRVFPHPNRMQAGEIGEMKDGVPEGAQLQVHRNPTYRPRFRRGPARPRPAPAIGEAEDKENQQAANGPNQPSARRGFRRPYNYRRRPRPLNAVSQDGKETKAGEAPTENPAPATEQSSAE
Protein: F9L1.37 (Late embryogenesis abundant-like protein) (Q9XI27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASGQDEEFSVRAGQIVGQAHVKENDCNNSSQASGFLQQKGEKVKSMAHDASEAVKNKLGINNDNNEEYKNKNPLDKKNPNNTTSPSMPGHPPSDI
Protein: LRR receptor kinase BAK1 (EC 2.7.11.1) (BRI1-associated receptor kinase 1 homolog) (OsBAK1) (Benzothiadiazole-induced SERK1) (BTH-induced SERK1) (OsBISERK1) (Somatic embryogenesis receptor kinase 1) (OsSERK1) (Q6Z4U4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: LRR receptor kinase involved in defense response. Does not seem to be required specifically for XA21-mediated immunity or basal resistance to Xanthomonas oryzae pv. oryzae (Xoo), or immunity to Magnaporthe oryzae. Involved in brassinosteroid (BR) signaling pathway. Acts as coreceptor of BRI1. Forms at the plasma membrane a receptor complex with BRI1 which is activated in response to brassinolide. Phosphorylates BRI1. Required for normal plant growth and leaf development. Possesses kinase activity in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19754838}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Brassinosteroid LRR receptor kinase BRI1
- non-specific serine/threonine protein kinase
- LRR receptor-like serine/threonine-protein kinase FLS2
Sequence:
MAAHRWAVWAVLLLRLLVPAARVLANMEGDALHSLRTNLVDPNNVLQSWDPTLVNPCTWFHVTCNNDNSVIRVDLGNAALSGTLVPQLGQLKNLQYLELYSNNISGTIPSELGNLTNLVSLDLYLNNFTGPIPDSLGNLLKLRFLRLNNNSLSGSIPKSLTAITALQVLDLSNNNLSGEVPSTGSFSLFTPISFANNPSLCGPGTTKPCPGAPPFSPPPPYNPPTPVQSPGSSSSTGAIAGGVAAGAALLFAIPAIGFAWYRRRKPQEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDTFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERPPSEPPLDWRTRRRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKRLEMLVDPDLQSNYIDVEVESLIQVALLCTQGSPTERPKMAEVVRMLEGDGLAERWEEWQKIEVVRQEVELGPHRNSEWIVDSTDNLHAVELSGPR
Protein: Fructose-bisphosphate aldolase 8, cytosolic (AtFBA8) (EC 4.1.2.13) (Cytosolic aldolase 1) (cAld1) (Q9LF98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fructose-bisphosphate aldolase that plays a key role in glycolysis and gluconeogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12953116}. Mitochondrion outer membrane {ECO:0000269|PubMed:12953116}. Note=Found in circular or rod-shaped bodies that colocalizes with mitochondrion marker. {ECO:0000269|PubMed:12953116}.
Interaction partners:
- Triosephosphate isomerase, cytosolic
- Triosephosphate isomerase, chloroplastic
- Sedoheptulose-1,7-bisphosphatase, chloroplastic
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- Aldolase-type TIM barrel family protein
- Glucose-6-phosphate isomerase, cytosolic
- Phosphoglycerate kinase 2, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
- transaldolase
Sequence:
MSAFTSKFADELIANAAYIGTPGKGILAADESTGTIGKRLASINVENVETNRRNLRELLFTAPGALPCLSGVILFEETLYQKSSDGKLFVDILKEGGVLPGIKVDKGTVELAGTDGETTTQGLDGLGDRCKKYYEAGARFAKWRAVLKIGENEPSEHSIHENAYGLARYAVICQENGLVPIVEPEILVDGSHDIQKCAAVTERVLAACYKALSDHHVLLEGTLLKPNMVTPGSDSPKVSPEVIAEHTVRALQRTVPAAVPAIVFLSGGQSEEEATRNLNAMNQLKTKKPWSLSFSFGRALQQSTLKTWAGKEENVKAAQEALYVRCKANSEATLGTYKGDAKLGDGAAESLHVKDYKY
Protein: Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) (P27139)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the reversible hydration of carbon dioxide (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00918}. Cell membrane {ECO:0000250|UniProtKB:P00918}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). {ECO:0000250|UniProtKB:P00918}.
Interaction partners:
- Sodium/hydrogen exchanger 1
- Band 3 anion transport protein
- Electrogenic sodium bicarbonate cotransporter 1
- Chloride anion exchanger
- Carbonic anhydrase 1
- Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
- Serine incorporator 5
- Cathepsin K
- Anion exchange protein 4
- Sodium/hydrogen exchanger 3
Sequence:
MSHHWGYSKSNGPENWHKEFPIANGDRQSPVDIDTGTAQHDPSLQPLLICYDKVASKSIVNNGHSFNVEFDDSQDFAVLKEGPLSGSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQHPDGLAVLGIFLKIGPASQGLQKITEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMSHFRKLNFNSEGEAEELMVDNWRPAQPLKNRKIKASFK
Protein: 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) (EC 4.1.2.51) (2-dehydro-3-deoxy-galactonate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase) (EC 4.1.2.-, EC 4.1.2.21) (Q6KZI8)
Organism: Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828 / KAW 2/3)
Function: Involved in the degradation of glucose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal). It is equally active with both D- and L-glyceraldehyde.
Interaction partners:
- D-gluconate/D-galactonate dehydratase
- D-glyceraldehyde dehydrogenase
- 2-keto-3-deoxy gluconate aldolase
- Transcriptional repressor/ROK family
- Glucokinase
- Triosephosphate isomerase
- Ribulose-phosphate 3-epimerase
- Pyruvate kinase
- Phosphoglucomutase/phosphomannomutase
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MITPLDAHGNIDYNATNILIKYLEGINVDYLFPMGSTGVFPYFTLKERKDFLKFVRENSKKPIMAGVGSSSINEVNELMKFSMDIGIEAAVLMPPYYIKLNQEAIYHYYKEILSSNDMDLLIYNIPQFTNKIDPETVKNLKSEFSSVKGVKDSSADIRGFMEMLSLSDDDFAVFQGQDDLLFTSLELGASGGVCGTTNFSDGIVRLYHEYKNNREMALKIEKNDVIPLMKKLGKYQFPNAYYEYFYKKNNINGGYRPPMYRVGIEI
Protein: Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (Suppressor of RNA polymerase B 5) (P32585)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 9
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 11
Sequence:
MVQQLSLFGSIGDDGYDLLISTLTTISGNPPLLYNSLCTVWKPNPSYDVENVNSRNQLVEPNRIKLSKEVPFSYLIDETMMDKPLNFRILKSFTNDKIPLNYAMTRNILHNTVPQVTNFNSTNEDQNNSKHTEDTVNESRNSDDIIDVDMDASPAPSNESCSPWSLQISDIPAAGNNRSVSMQTIAETIILSSAGKNSSVSSLMNGLGYVFEFQYLTIGVKFFMKHGLILELQKIWQIEEAGNSQITSGGFLLKAYINVSRGTDIDRINYTETALMNLKKELQGYIELSVPDRQSMDSRVAHGNILI
Protein: Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4) (Q62420)
Organism: Mus musculus (Mouse)
Function: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000269|PubMed:21849472}. Presynapse {ECO:0000250|UniProtKB:O35179}.
Interaction partners:
- Synaptojanin-1
- Dynamin-1
- Synaptojanin-2
- E3 ubiquitin-protein ligase CBL
- Dynamin-2
- Epidermal growth factor receptor
- E3 ubiquitin-protein ligase parkin
- Amphiphysin
- Clathrin coat assembly protein AP180
- SH3 domain-containing kinase-binding protein 1
Sequence:
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH
Protein: Proline transporter 3 (AtPROT3) (Q9SJP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Proline transporter that mediates proline and glycine betaine transport. When expressed in a heterologous system (yeast), imports L-proline, glycine betaine and GABA across the plasma membrane.
Subcellular location: Cell membrane {ECO:0000305|PubMed:15618414}; Multi-pass membrane protein {ECO:0000305|PubMed:15618414}. Note=Plasma membrane.
Interaction partners:
- AP-5 complex subunit beta-like protein
- WAT1-related protein At5g45370
- Tubby-like F-box protein 1
- Tetraspanin-13
- Delta-1-pyrroline-5-carboxylate synthase B
- Peroxidase 6
- GDSL esterase/lipase At2g19050
- Cationic amino acid transporter 7
- Geranylgeranyl transferase type-2 subunit alpha 1
- Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial
Sequence:
MNSKNRINNVGEGVDIEIPDTAHQISSDSWFQAAFVLTTSINSAYVLGYSGTVMVPLGWIGGVVGLILATAISLYANTLVAKLHEFGGKRHIRYRDLAGFIYGRKAYCLTWVLQYVNLFMINCGFIILAGSALKAVYVLFRDDHAMKLPHFIAIAGLICAVFAIGIPHLSALGIWLAVSTILSLIYIVVAIVLSVKDGVKAPSRDYEIQGSPLSKLFTITGAAATLVFVFNTGMLPEIQATVKQPVVKNMMKALYFQFTVGVLPMFAVVFIGYWAYGSSTSPYLLNNVNGPLWVKALANISAILQSVISLHIFASPTYEYMDTKFGIKGNPLALKNLLFRIMARGGYIAVSTLLSALLPFLGDFMSLTGAVSTFPLTFILANHMYYKAKNNKLNTLQKLCHWLNVVFFSLMSVAAAIAALRLIALDSKNFHVFADL
Protein: Acetylcholine receptor subunit beta-type lev-1 (C6KRN0)
Organism: Caenorhabditis elegans
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MMLGGGGGCGAGGTWLGFLVFLAVSLRNHSTCEDIDAEDRLMVDLFRGYNSLVQPVRNRSELPMIVKIGMQLVLLINVDEKEQVMHTNVWLTMKWDDFQLKWDPRDYANITQIRVAPEKVWLPDIVLFNNADGNYEVSFMCNVLILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLTFGSWTYNRDEIKLDFLTSDRVDFSEYSTSSIWDMMDGPAVLTSDRSRIEFQIRIRRKTLFYTVVLILPTVLMAFLNVTVFYLPTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPLVAKSPITHRLPPWVRKVFLDILPLLMCMQRPHRKNVIQRSHRRLLETGPSVEENPMRSGEHHPLCRHTHNQDSCRRVRIQSDELDDELSPEAQRAIDAIEFITENRRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVFETFDENATLVKLKQLYDMGLANDTVLGIF
Protein: RanBP2-type domain-containing protein (Q389R0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRKPSGVPKRIFATCRYAKKHSIGMGAASSDLQLVISADLWDDGLSFTALTTSTEAIQHSPEALLNNANRPLLIPFLQLLYRRGALMDERRRREIARYLVPSVHHDHLPWLWRDSAGSSPTVVIRGDVSALRSLLPSTWRAAIDHGGAAEPSERLHYWHQVFFAIASNPAFAEPSAFDQAHRELLAIVRDYYTDVLRLQELLPPLADDVTVTRMPPVLVRKLRKLYSEQCRLLQYAEFFRAAVEGEELVMPTCGTALVNDVDVFEYYLTIPGRRESGMGRDERWASTLEYAAFAFRKLFRQLNWKVTDISALMTRPAGILMNACVFARNDNAEGDRYREAILTMMSVFRSFCKEGGNSGGAGASSACDSAAVAACSLLRVLRDAGVSSMLAKCKALHFGPMRGLLDVCTVAAVLELLLCEEAIAEARDNRRSFIWNELEVLLSHRKIVGDEMYVAASGHPHHRRAAHYGIVNLGARIASALFDVVRSASALGKYAGELVKWGLLIGRPLRMTICDAPLTHLTSFLPWLSLNQLEREAEGLKAGMKAASSWTCGCECVNPIQLGAVSCAACVSRHLVEHAWTCPHCSWVSSSGDYIDTCFACSHPHPRGLSVEHDNRVLCVKTHGGAATPCLWACDYCHSYSQLGVSRNNSKVQTCMDCGAGDTGWAASFFEWKCGCGAVNSPLRRWCSVCSFGKADASCVCVYCREWWRLRLRRLGLRDECPACAAPHPRDVAAFERRLWRCPFCHSLTPDSARSCQNCQRPMGMLSQFLPLLPDVPWHCHACGGRHNHRDDEGVLLQTKPERNCSDVCMHCGVHRLDPVLFNRHEAWTCGVCGDVAVHGWCCRRCYALHPAVPSTEVHVWQCVVCRSVNNSWDGYCQRHGCGTRRSADTITLQYAPWCCVCCGKFSRTSQVPQCEHCEAVRSEDRMEVAGAADERHGRRLADVEAQLLSASPSAAGDFLCDELLELMSRRTAAGDWPCCISDSVQLSIPLV
Protein: Myosin-binding protein 2 (Q9CAC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:23995081}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Myosin-17
- Myosin-6
- Myosin-5
- Protein GRIP
Sequence:
MAANKFATLIHRKTNRITLILVYAFLEWSLIFFILLNSLFSYFILRFADYFGLKRPCLFCSRLDRFFDASGKSPSHRDLLCDDHALQLHSKPVEESNCGFGEFHNDLVHRGCCVEKISSSLCAPIESDFGNLDYPIGDEGQIYNGLKFPRSIFVFEEEKVGSVNLNDSQEETEEKKVPQSHEKLEDDDVDEEFSCYVSSFDCKNKEIATEKEEENRVDLPIEVETAESAPKNLEFYIDEEDCHLIPVEFYKPSEEVREISDINGDFILDFGVEHDFTAAAETEEISDFASPGESKPEDAETNLVASEMENDDEETDAEVSIGTEIPDHEQIGDIPSHQLIPHHDDDDHEEETLEFKTVTIETKMPVLNINEERILEAQGSMESSHSSLHNAMFHLEQRVSVDGIECPEGVLTVDKLKFELQEERKALHALYEELEVERNASAVAASETMAMINRLHEEKAAMQMEALQYQRMMEEQAEFDQEALQLLNELMVNREKENAELEKELEVYRKRMEEYEAKEKMGMLRRRLRDSSVDSYRNNGDSDENSNGELQFKNVEGVTDWKYRENEMENTPVDVVLRLDECLDDYDGERLSILGRLKFLEEKLTDLNNEEDDEEEAKTFESNGSINGNEHIHGKETNGKHRVIKSKRLLPLFDAVDGEMENGLSNGNHHENGFDDSEKGENVTIEEEVDELYERLEALEADREFLRHCVGSLKKGDKGVHLLHEILQHLRDLRNIDLTRVRENGDMSL
Protein: Adcyap1a protein (Adenylate cyclase activating polypeptide 1a isoform 2 precursor) (Adenylate cyclase-activating polypeptide 1a) (Q5XJ29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Adenylate cyclase-activating polypeptide 1a
- Vasoactive intestinal peptide receptor 2
- Adenylate cyclase-activating polypeptide 1a
- Vasoactive intestinal peptide receptor 1b
- Vasoactive intestinal peptide receptor 1a
- Growth hormone-releasing hormone receptor a
- Glucagon b
- Growth hormone-releasing hormone receptor b
Sequence:
MITSSKTTLAFLIYGLLVQCNVCSPLSYPKIRMETAGFDEEGNSLTDVTFDSDQITIRSSPTVTEDAYTLFSPPSKRLERHADGMFNKAYRKALGQLSARKYLHTLMAKRVGGGSTTEDDNEPLSKRHSDGVFTDSYSRYRKQMAVKKYLATVLGKSPEDLDLHQFLQDVDFGVLPDEDEIEAFLLDWLRQFSSEFPAL