wanglab/gogpt-training-data huggingface dataset:
Protein: Dual specificity mitogen-activated protein kinase kinase hemipterous (MAPKK) (EC 2.7.12.2) (Q23977)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis.
Interaction partners:
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase 7
- Mitogen-activated protein kinase kinase kinase
- Connector of kinase to AP-1, isoform E
- Apoptotic signal-regulating kinase 1, isoform C
- Putative mitogen-activated protein kinase kinase kinase 7-like
- FI16976p1
- protein-tyrosine-phosphatase
- JNK-interacting protein 1
- Transcription factor Jra
Sequence:
MSTIEFETIGSRLQSLEAKLQAQNESHDQIVLSGARGPVVSGSVPSARVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLPHNNQTLITDAATAAAAAATATTPPNIAATVLTTTPTTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQQNQLREKEAAERYQQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAINPASISPSSGSGTGNMAGLGIGSAPASGLGAAGHFGAGGTGEQLQYQPLPIAAEATGTSPTLQSRSPEQQSDYGGNGNMVASKLSKLYARRQLLGQSSSSGASNSSLDGCSREQHDAGWFNTLAGAMKRQFATYVKTQLNSTATSPVASSMDRDQEPVHPQPPAYRSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSPTTEPLPGGGTSSFLRRYASSGPGGSISTPPSPHILAGLDRRHRSPDPPPRYNRGQSPLLLRKNLLELSGQPPGSPLLHRRYVSASPPLPPPRRGSESVPGSPQHFRTRIHYTPEPQRRIYRTIDQ
Protein: Defective proboscis extension response 10, isoform A (Defective proboscis extension response 10, isoform B) (Defective proboscis extension response 10, isoform C) (Q9VT83)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dpr-interacting protein alpha, isoform A
- GEO05126p1
- Common Dpr-interacting protein
- Enhancer of split m4 protein
Sequence:
MLTLWTALFCCLTGLAVCYQRQSVSNNNHNNAEAKPTHAPPSHYPHGHKWNEPYFDLTMPRNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDIDEWTLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVYQSSNDEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLSEETSGGRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTEIASIRVHVLQGERPEAMQTNAAPAAVALACWSCHFGQATQAVRVISTMVAALVLLEACSSLLLQSGGGGGCPGGGSPAGGMPTRVREIREKPLTNSLLDPKIPSTTSAERVNNGSRNAR
Protein: Myotrophin (Q3T0F7)
Organism: Bos taurus (Bovine)
Function: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha-1
- F-actin-capping protein subunit alpha
- F-actin-capping protein subunit alpha-2
- Ankyrin repeat and SOCS box protein 15
Sequence:
MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ
Protein: Probable cytochrome P450 6a13 (EC 1.14.-.-) (CYPVIA13) (Q9V4U9)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFTTDVIGSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGLERP
Protein: Protein TMA23 (23 kDa translation machinery-associated protein) (Q03525)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Trans-acting factors of the ribosome biogenesis process.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17425675}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA34
- Uncharacterized protein YNL050C
- Ribosomal RNA-processing protein 14
- Protein PXR1
- Protein MAK16
- Suppressor protein SRP40
- Ribosomal RNA-processing protein 15
Sequence:
MDSKEYLISYGWKEGEAFREGGLKRPILVKHKRDKKGLGNAPGGNDGEAWWERLFDGHLKNLDVSTDSNNGSIKFTQNEAVATAVSKSSSPLYRWFVKGEGLKGTITNLGKKEEASFVVSSASSSKGKKRRRRDEDDNKVKRKKLKKDKKTSNDSESKKKKKKKSKKESKKGKKSKHSSDEGDKSKHKKSKKSKKHKKEESSARRDRKEHI
Protein: DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Q9SIE0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Alkylated DNA repair protein ALKBH8 homolog
- DNA N
- DNA N
- DNA N
- tRNA
- RNA demethylase ALKBH10B
- RNA demethylase ALKBH9B
- YTH domain-containing family protein
- Putative disease resistance protein At1g63350
- FKBP12-interacting protein of 37 kDa
Sequence:
MTNPLNSTAANRSNQPSSDGISDGQITNEEAESLINKKNCSGHKLKEVTDSDTFSDNGKDDSDTKKRFHYHQDQRRMSLTSIVAVESPSSSNAPSRKTIDLGHGSDLIYIQRFLPFQQSWTFFDYLDKHIPWTRPTIRVFGRSCLQPRDTCYVASSGLTALVYSGYRPTSYSWDDFPPLKEILDAIYKVLPGSRFNSLLLNRYKGASDYVAWHADDEKIYGPTPEIASVSFGCERDFVLKKKKDEESSQGKTGDSGPAKKRLKRSSREDQQSLTLKHGSLLVMRGYTQRDWIHSVPKRAKAEGTRINLTFRLVL
Protein: ATP-dependent RNA helicase (F4IFU5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Homeobox-leucine zipper protein HDG1
- Alpha/beta-Hydrolases superfamily protein
- At2g32090/F22D22.16
- Probable purple acid phosphatase 20
- Triacylglycerol lipase-like protein
- Ethylene-responsive transcription factor ERF107
- 3-ketoacyl-CoA synthase 8
Sequence:
MKAPNMETITESLEKSMMNCSLNDRRRRVVGDGFGRSSSNEHMTPISDRTLELNSHLSLPCHWEQCLDLKVKLITTETSNSCRFRTGEIYYINWKNGMRVKEDPRKVMNADPDSGDSYGTVCSEEDSSYYDSEESSSESSPSSRENHKEEEEEEEEEEEEEEDVLVVAGCKACFMYFMVPKLVEDCPKCAAQLLHFDRPHSASS
Protein: Outer capsid glycoprotein VP7 (P03533)
Organism: Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
Function: Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved (By similarity). Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7 (By similarity).
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04131}. Host endoplasmic reticulum lumen {ECO:0000255|HAMAP-Rule:MF_04131}. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles. {ECO:0000255|HAMAP-Rule:MF_04131}.
Interaction partners:
Sequence:
MYGIEYTTVLTFLISIILLNYILKSLTRIMDCIIYRLLFIIVILSPFLRAQNYGINLPITGSMDTAYANSTQEETFLTSTLCLYYPTEAATEINDNSWKDTLSQLFLTKGWPTGSVYFKEYTNIASFSVDPQLYCDYNVVLMKYDATLQLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIKVCPLNTQTLGIGCLTTDATTFEEVATAEKLVITDVVDGVNHKLDVTTATCTIRNCKKLGPRENVAVIQVGGSDILDITADPTTAPQTERMMRINWKKWWQVFYTVVDYVDQIIQVMSKRSRSLNSAAFYYRV
Protein: 3-hydroxy-3-methylglutaryl coenzyme A reductase 2-A (HMG-CoA reductase 2) (Hydroxymethylglutaryl-CoA reductase) (PgHMGR2) (EC 1.1.1.34) (A0A0A1C930)
Organism: Panax ginseng (Korean ginseng)
Function: Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants (By similarity). Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A0A1C3I2}; Multi-pass membrane protein {ECO:0000255}. Plastid, chloroplast membrane {ECO:0000250|UniProtKB:A0A0A1C3I2}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000250|UniProtKB:A0A0A1C3I2}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in intracellular vesicles. {ECO:0000269|PubMed:24569845}.
Interaction partners:
Sequence:
MDVRRRPVKSLSSAKTATAGEPPKSQQQHPKASDALPLPLYLTNGLFFTMFFSVMYFLLHRWREKIRNSTPLHVVTLSELAALVLLMASVIYLLGFFGIGFVRSVIRPSPDAWDILEDDNAINEEDSRREPCAEAIDCSLPPKPKIVHMVPQKALNPKSAFADMMVEQPALAIAPLTEEDEEIVKSVVTGKIPSYSLESKLGDCKKAASIRREALQRITGKSLAGLPLDGFDYKSILGQCCEMPVGYVQIPVGIAGPLLLNETEYSVPMATTEGCLVASTNRGCKAIYASGGATSVLLRDGMTRAPVVRFSTVKRAAELKFFLEEPLNYDTPAHVFNKSSRFGRLQGIKCAVAGKNLYIRFTCSTGDAMGMNMVSKGVQNVLDFLQSDFPDMDVMGISGNYCSDKKPAAVNWIEGCGKSVVCEAIIKEEVVKKVLKTNVAALVELNMLKNLAGSAVAGALGGFNAHASNIVSAVYISTGQDPAQNVESSHCITMMEAVNNGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASKESPGSNSRLLASIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSSKDITKLSS
Protein: Short-chain dehydrogenase/reductase (Shroud (EC 1.-.-.-, EC 1.1.1.239, EC 1.1.1.62)) (Q9VAH3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- hydroxymethylglutaryl-CoA lyase
- Cholesterol 7-desaturase nvd
- Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
- Cytochrome P450 302a1, mitochondrial
- RE15974p
- Spookier
- Cytochrome P450 307a1
- Probable cytochrome P450 6t3
- Ecdysone 20-monooxygenase
- Glutathione S-transferase E14
Sequence:
MSGSQLLRALRRSLGLGRQQLKVDSRHVVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTLELDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGEFEWQLTEQIEAQINCNLLGTMRLTHELLPLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYGMEVVNFIPGSFVLDSNIAARQQQHAQKMREAFSAEQHALYDTYFEAFNGYLKVLSGFKPPNRLRNESLLAKFKDALTSSQPLALYIEEPRRYRLYRWLFTLCPTPLVDWLTVRFCAMPTYESTNRQEKI
Protein: HoloCentric chromosome binding Protein (O76447)
Organism: Caenorhabditis elegans
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim10
- Kinesin-like protein klp-19
- Protein CLASP-2
- BHLH domain-containing protein
- Mitochondrial import inner membrane translocase subunit Tim8
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- Histone H3-like centromeric protein hcp-3
- Kinetochore null protein 2
- Spindly-like protein spdl-1
- Kinetochore-associated protein rod-1
Sequence:
MDESPIFDNENKRSAGNKRQQTESPFSAATPKSRLGREPKRIFGTSSGNMADSNLEETCLEHDSRPSSASSITPADNTSLLDLSTVTALATDDASFVGTNDASITPGSNVDVNLEQSELYDTSNCTSNLSMVQESDETDADATLSNDFDNQLALDGETTPTASRTPMSQILSRECTPTVSNPQLLTEIAKGVDQPTKPVRDVPQSPVLPVKGHIDFSLHEFEMLEQNSEHEESIKLLQSQIELLRQSHSQQLSEIQEARIFEEKMLTQQVDSAMKKAKSDREAAKAREQVLEKQVQELRLKLEEPDEEKNQLVHNLAALNAQIEELTQKALKVDSMQQGATASEDRIRELIGGHQEAIKQLENTKQMNESLQRDLVEKEARFSEEMERIRTESQTTSESLKYEHELVRKMMIEDMEKLEAEVLALKSQQANLEIQEFHDKIKQLELEVQLSSENKEKLQAELMVVQEKASENIKNAEEKVNGLEAEVEKLRFEATNNSRVVELEQQLEEFRSLMIKEISDLENQLEAAKLESGSTSEPNAQLEASQATIQELTSEMKMQLEEVKRQSDENNSLNVHLTSSNEKIAELTSSLEMVAAQLLSSQQETDVAVTKVENLELKMEEAHRMYLLDIELSRVKIDELQSSIEVLSKLEREVQSSNLQNEELKLSLRNFEELQADLAMSKAKNEELEQQIEDSSREFSVITEASKEMKLKWDSSEAQMSEMIASLAAFQEEMQSTQADAVASEDKVKQVESLLENLKEPLEELNNLRANLKDSNDKILDLQSQLELAQQSSDLADRLQEDLRTSDARVQELNIQVSELEQQIEVSSREFSVITEANKEMQLKLDSSEAQISEMTASLTAFQEEMQSTRADAVASEDKVKELESLLENLKEPLEELNNLRANLKDSNGKVLELQSQLDLAQQFSDLTDRLQEDLRTSDARVQELNVQVSDLQSELETARQDTNAVQVVMEALKSEQGESYEALRAELDAAVQEKGRSSDLVTSLEGKIQELETAIESSTAENVQKSKTIQDFTDKVSLLESQICELKSQNEQMEIDTNLNMDQLSEMSSQLESANAELIELTRTSAETIDKLRGEVEKSTKAMMDQEEHLAELVAKIESRDVENADQAAKHKEEQERLQSVIDTLRTSQSTIEESQAKSEELNSRIKELQASIEFAQKALADTENAKQEKVEELEKVQEQMLNLVQAFEVEKASIRLEWNSSLSNANEKLEAAEEALSQKENTIVTLESRIETISQQFEARLEEANVWKSQAMQLGTLTQSLSQMQRQLGEMHEKMEASDRRVIEVEEQAQHDITLIQVENKEQSEALEQAHSRILELEEKLVRAEIEIQRLEKVCDAFDDDEREYKDKIMTLQSEIKQLKGVKTPPRVMGLIEQARLGVKQLSRESSLVEPQNSAHEDAFEDAQNSFQDRLQTMSNTTARQIDASNHHPEDHVLEKSARETPSKKNRSNCQHQ
Protein: STARD3 N-terminal like (C9JJ39)
Organism: Homo sapiens (Human)
Subcellular location: Late endosome membrane {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004107}.
Interaction partners:
Sequence:
MNHLPEDMENALTGSQSSHASLRNIHSINPTQLMARIESYEGREKKGISDVRRTFCLFVTFDLLFVTLLWIIELNVNGGIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAIALTTAVTSAFLLAKVILSKLFSQGAFGYVLPIISFILAWIETWFLD
Protein: Protein kinase ATN1-like protein (Protein kinase superfamily protein) (Q9LVQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F10K1.14 protein
- Mitogen-activated protein kinase kinase kinase 20
Sequence:
MRPRGYQRAPSMQKPTDYPTDKTLHPNYPFLMSSHGLKSFESDDEDDDSDSSNDQFAFTINTELLVDVKDISIGDFIGEGSSSTVYRGLFRRVVPVSVKIFQPKRTSALSIEQRKKFQREVLLLSKFRHENIVRFIGACIEPKLMIITELMEGNTLQKFMLSVRPKPLDLKLSISFALDIARGMEFLNANGIIHRDLKPSNMLLTGDQKHVKLADFGLAREETKGFMTFEAGTYRWMAPELFSYDTLEIGEKKHYDHKVDVYSFAIVFWELLTNKTPFKGKNNIFVAYAASKNQRPSVENLPEGVVSILQSCWAENPDARPEFKEITYSLTNLLRSLSSDTDATSSNSKANIATEDSTSSLVQERVVCDCPGLKMSKTKKLKKKTNKLMNMIVPFLKIFKSCMSK
Protein: Zinc finger protein 688 isoform 4 (A0A0S2Z5X4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPPPAPLLAPRPGETRPGCRKPGTVSFADVAVYFSPEEWGCLRPAQRALYRDVMQETYGHLGALGDVPNRKEEEPEEVPRAKGPRKAPVKESPEVLVERNPDPAISVAPARAQPPKNAAWDPTTGAQPPAPIPSMDAQAGQRRHVCTDCGRRFTYPSLLVSHRRMHSGERPFPCPECGMRFKRKFAVEAHQWIHRSCSGGRRGRRPGIRAVPRAPVRGDRDPPVLFRHYPDIFEECG
Protein: Sideroflexin-1 (D6RDG7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
Sequence:
MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTV
Protein: Protein tesmin/TSO1-like CXC 7 (AtTCX7) (F4JY84)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in development of both male and female reproductive tissues.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Proline-rich spliceosome-associated
- Retinoblastoma-related protein 1
- Ras-related protein RABG3d
- F-box associated ubiquitination effector family protein
- Protein ALWAYS EARLY 1
- Protein ALWAYS EARLY 3
- Protein ALWAYS EARLY 2
Sequence:
MEDLSNQNLLPRQSDISIPAEKMDSFQKSLEPPPCSPVKSSQQSETEVTPPQKPPLHQFGHNQVQKNRVSNQDPSTSRRHNEVESKENTPNKQQKHCNCKNSKCLKLYCECFASGSYCNGCNCVNCHNKLENESSRQVAISGILERNPDAFKPKIAGSPHGMKDLQENVQQVLLIGKHSKGCHCRKSGCLKKYCECYQANILCSENCRCQDCKNFEGSEERKALLHGSQVSDTYIQQMTNAAVNRAIDMSAYLYPPESRKRKSKDISDSVVSSYGVQYQRANHVRRNGENSLFSLPNNKAVSGSTTSAYRSSWSNTFQPHHVRELCSLLVSNSVDVANKLSDKGRKNDKGPSSLDGAQRVANEINDSPDCVLDANRMDEKPISPATRALMCDEEHEIGSEKETSARVKTSQEKEDTDTSSGIYLEQERQILSIFRDYLIQLSNRARINGKNIKSNTNPS
Protein: GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (Q9EQH1)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UQC2}. Cell membrane {ECO:0000250|UniProtKB:Q9UQC2}. Membrane raft {ECO:0000250|UniProtKB:Q9Z1S8}.
Interaction partners:
- Tyrosine-protein kinase SYK
- Growth factor receptor-bound protein 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Tyrosine-protein phosphatase non-receptor type 11
- Tyrosine-protein kinase Lyn
- TNF receptor-associated factor 6
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- SOS Ras/Rac guanine nucleotide exchange factor 1
- SOS Ras/Rho guanine nucleotide exchange factor 2
- Mast/stem cell growth factor receptor
Sequence:
MSGGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPMTSHMQPALSTSAPQEYLYLHQCISRRTENSRSASFSQGTRQKSDTAVQKLAQSNGHCINGVSNQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCREFGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNAMTVATSGDSAIAPPPRPPKPSQAETPRWGSPQQKPPIGENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPTRGSGESASWSAESPGKTAVGRSDSASSDENYVPMNPGSSTLLAMERAGDNSQSAYIPMGPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPRKSTGSVDYLALDFQPGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
Protein: Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) (Q99K82)
Organism: Mus musculus (Mouse)
Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14764092}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Interaction partners:
- S-adenosylmethionine decarboxylase proenzyme 1
- Spermine synthase
- S-adenosylmethionine decarboxylase proenzyme 2
- Spermidine synthase
- Ornithine decarboxylase
- Diamine acetyltransferase 1
- Gene model 853
Sequence:
MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNMTQEFFRHGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPPHVIQLGKPVRCIHWDQASAHPRGPEIEPRGEGDHNHDTGEGGQSGENPQQGRWDEDEPWPVVVECEDCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGP
Protein: Exocyst complex component 4 (Exocyst complex component Sec8) (Q54P76)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Midbody, Midbody ring {ECO:0000250|UniProtKB:Q96A65}. Cell projection {ECO:0000250|UniProtKB:Q62824}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96A65}.
Interaction partners:
- Exocyst complex component 5
- Exocyst complex component 8
- Exocyst complex component 3
- Exocyst complex component 7
- Exocyst complex component 1
- Exocyst complex component 2
- Exocyst complex component 6
- Protein transport protein sec1
- Conserved oligomeric Golgi complex subunit 6
Sequence:
MDDNEEKKLDENKISKVLSSIPEQYHKTSFQARRTALDYMRSSNRKELLNQIGDWLDEVNVETDNIVDVYFQGFNKSIHNYSRILEFMGTSHGNALLMSKEVEETNKLINFNGTGIERLWKRNLEYYYMIEILEKMEELKKVPDLLNKYIKGNHFVHAANILVNSISTLNERDLVNVNALMDLRQMLVEKKESFKDMLVEKLNDHIYLKTKSSLKAFEYDDENNLQSNFKKILLSNKNSNSNNSNNTFKSPLPPTTTSPFKPQFTGAFQTKASQEKAEKAAANLYNQERLSQSNQPEVLKLEEISKTSNSKEDLNIDPEQDGKLFMTLLVEALNVLEYLSPAVGLILGRISIELKTAITNSITLITNVYHSEGRVIPKMPGESSNSSNGSNGSNGGGNNSMNGSGGINGNGSTASSSSPTSSTSSNIGANGLSPSVLSKNSHIGSATFSNIDEYSAAFNFLTETFNRNDLLANQTHNIPLVDLLKMIFNKVNMVFKNHLQLSKIFNDAIRKSELKIRANKFDFKEETEGGGGDSDNDFEGTPKPTKLQKSKVEIADVYDASLVWEIIQKEIREMLRVHLQDTSSLLLSTKSRLNPDGTESNSGKSQRLFSFTNSIVTDNWNGSISPMVTTSPTSPNGTSGADAIDSNSGGPAVISIFKASQYNVTPIYPMIVKFTDHLDKTLRDRTGTPTTTKTTTTITTTTTNSYHNQNSKKGLLRLYIDDFVHRNFLQHIKNDYKDRFAHSIESTEAFKPLERYKLVFRLKETKPILNSTLQIFQFVIELFSDIVAMSHYVVEFGAIIQVSLLRYYEKCLSKFSQEIDPTLTNQLLNTDLYKYLLASLAVSSKKQDVAKFQDSREEEYEFKLESDLFNHPEKPVLKNQLILNIEKLTMLANMSHSLNWLADKIVQLLIVQEDQKEKYTQQQQQQQQQQQQVDSIKTPSKLNSGINSGGNSTASNKENNSTTTGSNNFIGTFNQMSAESIEALKTMEEPIKDIAQRFKDLSKRCLLALRIEYRIHCFYFLEGFKRAQYMCEEERTDPDSFIVELNKDLSASEEMMSIYLTSDKCNFLFSGIAKLIGKLLISKLVHVNSINDNGVAKLCKNVFTLQQNLSNIIVKREIFFDRIRQFYQALSAEDELLNYLLEKMSQPFFSLEEGKIIIDFLQRTKRISPNAILTLEAKYKNM
Protein: Proteasome subunit beta (E9KL30)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
Protein: UBC core domain-containing protein (Q5F405)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAGPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
Protein: Vitellogenin 2 (Q1MTC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Estrogen receptor
- Aromatase
Sequence:
MRAVVLALTLALVASQQNKLVPEFAHDKTYVYKYEALLLSGIVQEGLAKAGIQIKSKVLLSAATENTFLLKFVDPLFYEYAGTWPKDQVFPATKLNSALAAQLQTPIKFEYANGVVGKVFAPAGVSPSVLNLYRGILNILQLNFKKTQNIYELQEAGAQGVCKTQYVISEDPKADRITVTKSRDLSHCQERIVKDIGLAYTETCVECTKRIKSLIETANYNYIIKPSDSGALIAEATVKEVHQFSPFNEIHGAAMMEATQSLVFVEFEKAPVVPVKADYMPRGSLQYEFATEILQTPIQLTKISNAPAQIKEVLKHLVENNVAMVHDDAPLKFVQLVQFLRAATLKDTEAIWAQFKDKPVYRRWLLDTLPAVATPVVLKFIKEKFLAGEFTLTEFIPTLVVALQMVPADLETIQWTASLALHEKIATIPALREVVMLGYGSMIAKYCVAVPTCPAELLRPIHEIATEAISKNDIPEITLALKVLGNAGHPSSLKPIMKLLPVLKTTASALPIRVQVDAILALRSIAKKEPKLVQPVALQLVLERALHPELRMVACILLFETKPSVAVMSSLAGALRMETNMQVASFAYSHIKSLTRITAPDMSSVAGAANVAIKLMNRKLDRLNFRYSRAFQLDFYHTPLMIGAAGSAYMINDAATILPRAVIAKARAYLAGAATDVIEFGLRTEGIQEALLKSPAADESVDRITKIKRTLRALTNWKAMPSNKPLASAYVKVFGQEMAFGRIDKTIIEQALPMVNGPKPRALLKEALKALQEGISWQRAKPLLVAEVRRILPTSVGLPMELSMYSSVVGAATVNVQATITPPLPEQIETMTLEQLKKTDVQFKAEARPSIAIHKFAVMGVNTAFIQAAVMARGKIRTIAPGKVAARADILKGNYKIEALPVELPEHIASASFETFAFARDVEDPSAERTVPLVSVLSLQNRQSQRLSSENADSEIETETPVKAPAPFDRTLCYAVPYIEIKGCVEVHSHNAAFIRNSTLFYIIGQHSARAAVARAEGPAVEKLEFEVQVGPRAAERLAKQINIIDDETPEGKDFLLKLREILETESKNATVSSGSSSSRSSSSSRSSSSSSSTSNSTSSSSSSSSSSSSMSSSRWSKTLTKMEAFRKFHKDQYKTHHGDSKSSRSTGSSLEQIQKQSRYLGNTVPPVFAIIARAVRVDRKLLGYQFVAFFDKPSSRVQFIASSIAENDNFKFCADGVLLSKHKVTSKVTWGAECKEYAVTTKAEAGLLGEFPAFRLEWEWERLPIIFTTYAKKLSKHIPMAALQAGFNVERAKNSEKELELTVALPSKRTLNVIVRVPEMTMSRMDIPLPVTFPINPDGTFDVHFYEDIYFRAQNYIYDYTTAQCSMMQDTISTFNNKTYKNEMPISCYQVLAQDCTSELKFVALLKKDEESEKTHLNVKLVDIDIDLYTLGTDAKVKINGLEVPISSLPYQHPSGSIQIREKADGLSLYAPSLGLHEVYFANGDWKIQVADWMKGQTCGLCGKADGEIKQEYTTPSGYLTESSVSFAHSWVLPAESCRDASQCRMKLESVKFEKQVILNGQESKCYSVEPVLRCLPGCAPVRTTPVTVGYHCMSTASNLNMLAGIYEKSVDLRETTDAHVACRCTEQCA