wanglab/gogpt-training-data huggingface dataset:
Protein: Knickkopf (RE24065p) (Q9VH23)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- UPAR/Ly6 domain-containing protein rtv
- LD43683p
- Vermiform, isoform I
- FI03450p
- chitin synthase
- RE49895p
- chitinase
Sequence:
MALSSRVLCLRLQHHLLLVILTIFLLCPAASAQNEEEDGPYRGKYLGKLNSYHHQVSGDVYAVNEYTFLIVGFNYDGNGADTFFWSGASNRPGPQGFIVPDEYGKTNILDRYHNKDFTLTLPDRKKITEIKWLAVYDLSSQNNFGDVYIPEEFDPPMSQLGGTFSKRSHNVSSSSVEILDSKTIRIKDFTYDGRGKRTFFWTGVGPQPSSRGSKLPDERGYLDPIRQYNKETIELELPGDKTIFDIDWISVYDVADNENYGHVLFNDKLNVPPSLVKVTPFEFSLPNCRQLHKDMQVSWEVFGPQITFQLSGQVGGNDYMSFGISGSDVSSQMIGSDVVVAYIDDIRGYTVDYNITSLAPCVQVLGQNKGVCRDDVVGGLDSFQLNTYSRKDGINTISFRRTLKSSDDGDKEIFLDRSNYVIWAFGPLDSNNEPAFHTYYPKSDIVIDFNTTEPVNDCFAFTKRAETTNPPVWERTRITDATVRTFNAYLGPSGGLRGYQGLTNHVSSGLAWYINGYMIPELYLKRGLTYTFKVRGGNNPHSPEHYHPLVITDDPQGGYDRLSDAKQSEIRVLAGVEFTRRGRPKPTAAGPLCLSRYPQNSDRRLDDNFPTFKKFNRSLITECVEGEPALLEITPNITWPDTVYYNSFTHGNMGWKIHIVDSYTNLKSGSMGLSWSLCIILLPWLVLQN
Protein: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) (Q16822)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:8645161}.
Interaction partners:
- Pyruvate carboxylase, mitochondrial
- Malate dehydrogenase, mitochondrial
- Alpha-enolase
- Beta-enolase
- Pyruvate kinase PKLR
- Gamma-enolase
- Citrate synthase, mitochondrial
- ATP-citrate synthase
- Enolase 4
- Pyruvate kinase PKM
Sequence:
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVPLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM
Protein: Arginine ABC transporter permease protein ArtM (P0AE30)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Putative ABC transporter arginine-binding protein 2
- ABC transporter arginine-binding protein 1
- Arginine transport ATP-binding protein ArtP
- Arginine ABC transporter permease protein ArtQ
- Glutamine-binding periplasmic protein
- Histidine-binding periplasmic protein
- L-cystine-binding protein TcyJ
- Lysine/arginine/ornithine-binding periplasmic protein
- Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP
- L-cystine transport system ATP-binding protein TcyN
Sequence:
MFEYLPELMKGLHTSLTLTVASLIVALILALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPTLQEYPALWHLLSEPWLCALIALSLNSAAYTTQLFYGAIRAIPEGQWQSCSALGMSKKDTLAILLPYAFKRSLSSYSNEVVLVFKSTSLAYTITLMEVMGYSQLLYGRTYDVMVFGAAGIIYLVVNGLLTLMMRLIERKALAFERRN
Protein: Serine/threonine-protein phosphatase 4 regulatory subunit 4 (Q6NUP7)
Organism: Homo sapiens (Human)
Function: Putative regulatory subunit of serine/threonine-protein phosphatase 4.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18715871}.
Interaction partners:
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase 4 regulatory subunit 1
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
Sequence:
MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAVYLLSAGQDVQGTSVIANLPFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTILQDESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSKAQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCEKSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIPPQILEQEKKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICFYEVSKLLNSGVYLIHKELITLLQDESLEVLDALIDHLPEILELMSTGGESSVQENKLSSLPDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFTIMMTNNVLPVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKSFFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEKDKDVLAIVKRTVLELDRMEMSMDAFQKKFYEKDLLDQEKEREELLLLEMEQLEKEKQQNDGRPMSDKMFEKKRRDTKTPTQSLPKNIPISVPGPSSVTPSTSKEIKKSKLIRSQSFNNQAFHAKYGNLEKCASKSSTTGYTTSVSGLGKTSVLSLADDSFRTRNASSVPSSFSPNTPLPSTSRGTGNSVDPKSSGSKDTQPRKATLKSRKSNP
Protein: Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) (Q5VTL8)
Organism: Homo sapiens (Human)
Function: May be required for pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing factor 38A
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- RNA-binding protein 25
- Serine/arginine-rich splicing factor 11
- Pinin
Sequence:
MANNSPALTGNSQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVGTGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFESFLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV
Protein: Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I beta) (GSI beta) (P0A1P6)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P9WN39}.
Interaction partners:
- Glutamate synthase large chain
- NADP-specific glutamate dehydrogenase
- Sensory histidine kinase/phosphatase NtrB)
- Glutamate synthase small chain
- DNA-binding transcriptional regulator NtrC)
- Carbamoyl phosphate synthase small chain
- Nitrite reductase large subunit
- Bifunctional protein PutA
- Carbamoyl phosphate synthase large chain
- Serine hydroxymethyltransferase
Sequence:
MSAEHVLTMLNEHEVKFVDLRFTDTKGKEQHVTIPAHQVNAEFFEEGKMFDGSSIGGWKGINESDMVLMPDASTAVIDPFFADSTLIIRCDILEPGTLQGYDRDPRSIAKRAEDYLRATGIADTVLFGPEPEFFLFDDIRFGASISGSHVAIDDIEGAWNSSTKYEGGNKGHRPGVKGGYFPVPPVDSAQDIRSEMCLVMEQMGLVVEAHHHEVATAGQNEVATRFNTMTKKADEIQIYKYVVHNVAHRFGKTATFMPKPMFGDNGSGMHCHMSLAKNGTNLFSGDKYAGLSEQALYYIGGVIKHAKAINALANPTTNSYKRLVPGYEAPVMLAYSARNRSASIRIPVVASPKARRIEVRFPDPAANPYLCFAALLMAGLDGIKNKIHPGEAMDKNLYDLPPEEAKEIPQVAGSLEEALNALDLDREFLKAGGVFTDEAIDAYIALRREEDDRVRMTPHPVEFELYYSV
Protein: Ras family guanine nucleotide exchange factor (A0A1D8PTC8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- GTPase activating protein BUD2
- Ras-related protein RSR1
- Pin3p
- Phosphatidylinositol-3-phosphate-binding protein
- Cell division control protein 42 homolog
- Rax1p
Sequence:
MFQQPNYSDPGKHISTSSSVYPDSNSASPESSPRIPGAFEQIIIPRHKENPFRTNKPIEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQHQEHQANGHDEEQNRMPTEGSNQTFQSYMTARSGAYSFEEEDYENEVAGHQDQQSENGSIYSQNQEPQLRNAPSFSSINESIFHNSSKNTTLDTTENDETPLIDSSERYPDETPIVDDNGFLHEINHGEKDIIASEPIDSNEPTSLLPKQNLSKKFKRVSVALQNTRTSGESYNFRYVFQNNVDQANRTATQDNTAPKLERKSTYYRKLQEKKLQSSQEQQGTEVENMVISNDQHSEASSISTRASSTHTDTSGRDDEQDDNLVKKNSTNSSSNFVFSNNNLPSSYNLGGSKVNDDIPIRKDLIRENKAQVQQDAIDRERLQMYNNSTAMSEEGGLNIVYKDANTTSDDTYSKPPSPTKSEEKEDNLSDFFIRALHSFDSSTLQSKSDASICLSFEKNDIAFLHTIDESGWGEVTLLETLQTGWIPMNYFSLVVTSSDDEEDEDDSYEDNDDDDSNKIPNNHYLKPLLHACGQFLSNPLSHKDRRNKYTFSIRVINSIRDGVRLLLQQTDCLSRSNELVTKRPIVRKSRKSLLADWYNLMVKANEFKGTSNYNKIEILTLMVYQVSRKAVSFLEIWSAESKEIITRDHTGKKLYDDLNDCPLLKTPPLAKQRITEIHGVLFSYLGLIIGRLDLIEHNQIGCDMLETLAHQIILLLRELLFVSRTGSEYSKDKPRELDSSLDGLLSLVSDLVASVKNLVVRTVNETEEDRIHKFGGPQLNGARDYYYTPEGGELLQIASRMVKAISVTVASIRKLLEVTGDFKLSSERSYPDYSKMRIEPQEFIKKCSQGITKPKDMPIQQPNGATSTSNSGGIKAYKANRYSMIRAGKTGDLGLTENGVNYLQSLNNENGNGNNVVDELDGSSPFTSSAPEFKPFTSEGGNESNNDANINANINNELSVDSNGNLLGGSFKGLVYTLTNEDSPPEYFFVSTFFICFRSFSTGIDLIEELITRFQVGYVSNDINIDLKLKKRRKLVAKSIQLWMESYWNHEADYNLLTTLINFFNEGMSDYLPLDAIRLIDIGARLSSRPLVENRSRRIKDTKQLVNRSITNAAKLPRKTGSILGDEINRYSMIDSYSLSKINSTSSSNSTTSSSGHSASLPMPLGPTSTSKTSLLTSSQLETIEKVNLTYRAILGNSWCSQKYINSIKYIPLDLSVLMPNFYIICDQSWVLSNYRPNLLDFNGLEIAKQLTLLESYIFCSIKPDELLNQNYTTKRAHLKLAPNVRLSLLFTNCLSGYVIESILQPNITIKLRISMVKIWLKIAISCLYLRNFNSLAAIITALESHLITRISSIWIKLEDKYTELYDYLSSIIHPEKNYRVYRNKLRNFLNSPMGLETPPIPIVPYFSLFLQDLTFINDGNPNYRKANTFLNQKLINIDKYLKITRIIADIECLQISYLDDPNIVGNGDGNSLMENGDDKPNYTINPVAPLQELILLELWKICQLNKTEEDRAWKLSCKIQPRDVS
Protein: Uncharacterized protein YMR316C-A (I2HB70)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MTGFKVSSFFYILALSRFFNAGRERACDKLKITVTHLYWFIIRKLLLHEVHVHVSRVCNVSFILSPCLFRNFFTLSLHVLYVMYEQALTPEFFRQWWDIIQSK
Protein: Zinc finger protein Eos (Ikaros family zinc finger protein 4) (Q8C208)
Organism: Mus musculus (Mouse)
Function: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1.
Subcellular location: Nucleus.
Interaction partners:
- Forkhead box protein P3
Sequence:
MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERELSGGCAPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLDKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTDAQALTGQPGDEIRDLEMVPDSMLHPSTERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNASGGYEKDVELVAHHGLEPGFGGSLAFVGTEHLRPLRLPPTNCISELTPVISSVYTQMQPIPSRLELPGSREAGEGPEDLGDGGPLLYRARGSLTDPGASPSNGCQDSTDTESNHEDRIGGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG
Protein: Myosin heavy chain (O96816)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
CCSRRAAQVRRRVPVLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKRQQRNS
Protein: Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1) (P22004)
Organism: Homo sapiens (Human)
Function: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
Subcellular location: Secreted {ECO:0000269|PubMed:26582087}.
Interaction partners:
- Bone morphogenetic protein receptor type-1A
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-2A
- Bone morphogenetic protein receptor type-2
- Hemojuvelin
- Activin receptor type-2B
- Noggin
- Chordin
- Bone morphogenetic protein 4
Sequence:
MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
Protein: Protein phosphatase 1 regulatory subunit (E1BC59)
Organism: Bos taurus (Bovine)
Subcellular location: Cytoplasm, cytoskeleton, stress fiber {ECO:0000256|ARBA:ARBA00004529}.
Interaction partners:
Sequence:
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKREKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDDEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVTNANTSSTQAAPVAVTTPTVSSGQPTPTSPIKKFPASATKISPKEEERKDESPASWRLGLRKTGSYGALAEITASKEAQKEKDTAGVMRSASSPRLSSSLDNKEKEKDSKGTKLAYVTPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSINEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTAEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDEAYQRYRPVSTSSSTTPSSLLSTMSSSLYASSQLNRPNSLVGITSAYSRGLTKENEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKEVQTDSISRYEISSTSASDRYDSLLGRSGSYSYSEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRVTGKSQYLLGGTKSSRKKNI
Protein: Cytosolic nonspecific dipeptidase, putative (Q389B7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVDWNTVHQTVSDHWDTSVVPGLSEFLEVPNQSPHYDKEWATNGHMKKAMDVVVKWIEKQPIKGMKYEVFEDEGLTPFLVVEIEGTEPCANTLLMYGHVDKQPPLLPWGEGLHPYKPVYRDGNLYGRGSADDGYAAYLAISAVAAVQKHGLQHGKVVVIIEASEESGSMDLPHYLRRCKDHIGNVDLLICLDSGGANHEQLWLTTALRGLCGGVLTVETMREGMHSGMSGGVVPDSFRIARMLLERIEDTNTGNVKIPEAICDIPEHVIKAAEVMRSIPLKKMFALLPGVAAEADDNAELALRSSWKAALTVVGDNLPDTATAGNVNRAKTTLRLSLRIPPVADAEKVSAAMKSILEADPPYNAKVNYTSHHDGTGSATPALKPWLAQALHSGCETAFGKTYASQGVGGTIPFVAMLQQMFPEAQFLITGVVGPRSNIHGPNECLNVPFAKGVTTCVARVIAEHFHATPKLRKD
Protein: Movement protein (30 kDa protein) (Cell-to-cell transport protein) [Cleaved into: 27.9 kDa protein; 25.3 kDa protein; 19.5 kDa protein] (P03583)
Organism: Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1))
Function: Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds microtubules and modulates microtubule stability. Can bind double-stranded DNA. Triggers host hypersensitive defense reaction in incompatible plants harboring resistance (R) proteins.
Subcellular location: Host cytoplasm, host cytoskeleton {ECO:0000250|UniProtKB:P69513}. Host cell junction, host plasmodesma {ECO:0000250|UniProtKB:P69513}. Note=Binds to the host cytoskeleton before being transported to the host plasmodesmata. Observed in virus replication complexes (VRCs) of tobamovirus infected host cells (By similarity). In resistant plants, targeted to the host plasma membrane via the interaction with host resistance (R) protein TM-2 (e.g. tomato ToMV resistance protein TM-2(2), AC Q71BG9) (PubMed:28258211). {ECO:0000250|UniProtKB:P69513, ECO:0000269|PubMed:28258211}.
Interaction partners:
Sequence:
MALVVKGKVNINEFIDLTKMEKILPSMFTPVKSVMCSKVDKIMVHENESLSEVNLLKGVKLIDSGYVCLAGLVVTGEWNLPDNCRGGVSVCLVDKRMERADEATLGSYYTAAAKKRFQFKVVPNYAITTQDAMKNVWQVLVNIRNVKMSAGFCPLSLEFVSVCIVYRNNIKLGLREKITNVRDGGPMELTEEVVDEFMEDVPMSIRLAKFRSRTGKKSDVRKGKNSSNDRSVPNKNYRNVKDFGGMSFKKNNLIDDDSEATVAESDSF
Protein: Protein ILM1 (Increased loss of mitochondrial DNA protein 1) (P47155)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MAQALNSTNIAFFRVAFLFTIAFFCLKNVNSILQNTYFIVLTQAMNLPQLTLSRYSGQLGLFALLFTLNGVHDLIPLLENNVKYFQSVVPVRLLIFFILTSISYLWESNFYVHNNSVFIYCFAEVWINFLLYNAIREEKNEEFKRLNQFMVNDEDIEEPQPFTVKTETTEIIEIINDEENDDEDGKDNDDNNEKGNDDSDAKK
Protein: Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) (Q8NEY8)
Organism: Homo sapiens (Human)
Function: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:12853457, ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:26022416}. Cytoplasm {ECO:0000269|PubMed:12853457}. Chromosome {ECO:0000269|PubMed:26022416}. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416). {ECO:0000269|PubMed:12853457, ECO:0000269|PubMed:26022416}.
Interaction partners:
- Protein TASOR
- M-phase phosphoprotein 8
- Periplakin
- Caspase-5
- Protein bicaudal C homolog 1
- Mitochondrial-processing peptidase subunit beta
Sequence:
MWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPENEGEETAQSAPQPPQAPQPLQPRKKRVRRTTQLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVVHCNSRKDVKPENKQ
Protein: Putative methyltransferase YGR283C (EC 2.1.1.-) (P53336)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit CBF5
- Putative methyltransferase YMR310C
- 25S rRNA
- H/ACA ribonucleoprotein complex subunit GAR1
- Protein arginine N-methyltransferase SFM1
- 25S rRNA
- Protein-lysine N-methyltransferase EFM2
- Ribosome assembly protein RSM22
- UPF0642 protein YBL028C
- U3 small nucleolar ribonucleoprotein protein IMP4
Sequence:
MAVKHKSESLKHEEGAAKKAKTGLLKLKKIMDIESNVVKYSICIPTTVIDNCNNLEQVTFTAYQIARTAVLFNVQEIIVLDQSKDKKHEKKSRSKETISDCLLLATLLQYFVTPPNLLDTTFKKKNKLYLKCASTFPPLNQLPFMNASAEQHYKEGLSIARDSSKGKSDDALTNLVYIGKNQIITLSNQNIPNTARVTVDTERKEVVSPIDAYKGKPLGYHVRMASTLNEVSEGYTKIVWVNSGDFHYDEELSKYHKVETKLPYIAKLKKSSTSEKPCNILLIFGKWGHLKRCFRRSDLESSSLHHYFSGQLQFPASVPQGNIPIQDSLPIALTMFQRWAS
Protein: Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (O15355)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Protein HEXIM1
- La-related protein 7
- Ubiquitin carboxyl-terminal hydrolase 7
- 7SK snRNA methylphosphate capping enzyme
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Sequence:
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD
Protein: Coronin-1C-A (B0R0D7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (Probable). Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9WUM4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WUM4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WUM4}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9WUM4}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9WUM4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9WUM4}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9WUM4}. Endosome membrane {ECO:0000250|UniProtKB:Q9ULV4}. Note=Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex (By similarity). Colocalizes with F-actin at the leading edge of lamellipodia (By similarity). Partially colocalizes with microtubules and vimentin intermediate filaments (By similarity). Localizes to endosome membrane tubules/buds (By similarity). {ECO:0000250|UniProtKB:Q9ULV4, ECO:0000250|UniProtKB:Q9WUM4}.
Interaction partners:
- Plastin-3
Sequence:
MFKRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSAFCAVNPKFVALIVEASGGGAFMVLPLHKTGRIDKAYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLVTSMSEPVVVLEGHSKRVGVVTWHPTARNVLLSAGCDNMIIIWNVGTGESMITLEDHHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKDKAHEGARPMRAIFLSDGKVFTTGFSRMSERQLALWDPENIDEPVAVHEMDTSNGVLLPFYDPDTNVVYLCGKGDSSIRYFEITDEAPFVHYLNTFTTKEPQRGMGYMPKRGLDVNKCEIARFYKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPDAPLEAEEWFEGKNGDPVLISLKHGYIPGKNRDLKVVKKNILDNKMSKNTENTTPAHKTATSTPSIKSEAKLEEVLKEIKSLRELVSSQEKRIGKLEEQLSKMDI
Protein: Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog) (Q9UST9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of small RNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein argonaute
- Trimethylguanosine synthase
- rDNA transcriptional regulator pol5
- Protein Dicer
Sequence:
MGVSSFYPPLHVQRRRKLFKILQGGFPVRSLLDIGCGDARFLSYLVPCNDQVPIEFLAGIDINEQSIERATEALQVRTEDFLQLRWRPLHIELLLGNIKDFTHYKHVDAVVASEFIEHCQVAEILAFEKLVFGNLKPNVCVVSTPNFEFNTIFEKLSTLTSSISSRTSTNFRHPEHVFEWDRKEFAKWAYKICKRYPEYTVEFTGCGLLNDLIDGDDLLHFRPSSTYGFCTQIAVFHQSKNNAASHCFLKDQNSSILLYKKITYPFMEQLFPPTVQQFMNLLKKAFFDHLFGRHCLLLFQVIAGKCALSVKLPFLFIWESSPLIRHAFHYDDSIYLSYCPELKKSKHKGIALANSFSFRIAKVLKKSRIFIITFHHYV
Protein: Cyclin-dependent kinase B2-1 (CDKB2;1) (EC 2.7.11.22) (EC 2.7.11.23) (Q8LF80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinases regulatory subunit 1
- Cyclin-A2-2
- Cyclin-A1-1
- Cyclin-A2-4
- Cyclin-A2-3
- Cyclin-A2-1
- Retinoblastoma-related protein 1
- Cyclin-B1-1
- Cyclin-D3-1
- Cyclin-dependent kinases regulatory subunit 2
Sequence:
MDEGVIAVSAMDAFEKLEKVGEGTYGKVYRAREKATGKIVALKKTRLHEDEEGVPSTTLREISILRMLARDPHVVRLMDVKQGLSKEGKTVLYLVFEYMDTDVKKFIRSFRSTGKNIPTQTIKSLMYQLCKGMAFCHGHGILHRDLKPHNLLMDPKTMRLKIADLGLARAFTLPMKKYTHEILTLWYRAPEVLLGATHYSTAVDMWSVGCIFAELVTNQAIFQGDSELQQLLHIFKLFGTPNEEMWPGVSTLKNWHEYPQWKPSTLSSAVPNLDEAGVDLLSKMLQYEPAKRISAKMAMEHPYFDDLPEKSSL