Protein: Protein sevenless (EC 2.7.10.1) (P13368)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein bride of sevenless
- Growth factor receptor-bound protein 2
- Protein daughter of sevenless
- Tyrosine-protein phosphatase corkscrew
- Protein son of sevenless
- Ras-like protein 1
- E3 ubiquitin-protein ligase CBL
- Epidermal growth factor receptor
- Inosine-5'-monophosphate dehydrogenase
- DShc protein
Sequence:
MTMFWQQNVDHQSDEQDKQAKGAAPTKRLNISFNVKIAVNVNTKMTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGISTILIINLLLLILLSICCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALKELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADGQSTPLTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQMVSPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESAQKVGESFDLPVEQLEVDALNGWIFWRNEESLWRQDLHGRMIHRLLRIRQPGWFLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLRWASRQGSVIHTNELGEGLEVQQEQLERLPGPMTMVNESVGYYVTGDGLLHCINLVHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNCVVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQDQLFWLVKGSGALRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLNLPMITASEDCPLPIPGVRYQLNLTLARGPGSEEHDHGVEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPLKDKQLYANEGVSRL