wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-related protein Rab-34 (EC 3.6.5.2) (Ras-related protein Rab-39) (Ras-related protein Rah) (Q9BZG1)
Organism: Homo sapiens (Human)
Function: Transport protein involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q64008}. Golgi apparatus {ECO:0000250|UniProtKB:Q64008}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid-anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Cell projection, cilium {ECO:0000250|UniProtKB:Q64008}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q64008}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:37384395}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.
Interaction partners:
- Rab-interacting lysosomal protein
- Protein unc-13 homolog B
Sequence:
MNILAPVRRDRVLAELPQCLRKEAALHGHKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGIPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYALMEKDALQVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEANVLAELEKSGARRIGDVVRINSDDSNLYLTASKKKPTCCP
Protein: Indole-3-acetic acid-amido synthetase GH3.10 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 10) (Protein DWARF IN LIGHT 2) (Q9ZNS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin (By similarity). Involved in red light-specific hypocotyl elongation. May act downstream of a red light signal transduction and determine the degree of hypocotyl elongation.
Interaction partners:
- Auxin transporter protein 1
- Serine/threonine-protein kinase SRK2J
- Two-component response regulator ARR16
- Serine/threonine-protein kinase SRK2G
- Serine/threonine-protein kinase SRK2H
- Serine/threonine-protein kinase SRK2F
Sequence:
METVEAGHDDVIGWFEHVSENACKVQSETLRRILELNSGVEYLRKWLGTVDVEKMDDYTLETLFTSLVPIVSHADLDPYIQRIADGETSPLLTQEPITVLSLSSGTTEGRQKYVPFTRHSAQTTLQIFRLSAAYRSRFYPIREGGRILEFIYAGKEFKTLGGLTVGTATTHYYASEEFKTKQETTKSFTCSPQEVISGGDFGQCTYCHLLLGLHYSSQVEFVASAFSYTIVQAFSFFEEIWREICADIKEGNLSSRITLPKMRKAVLALIRPNPSLASHIEEICLELETNLGWFGLISKLWPNAKFISSIMTGSMLPYLNKLRHYAGGLPLVSADYGSTESWIGVNVDPHLPPEDVSFAVIPTFSYFEFIPLYRRQNQSDICIDGDFVEDKPVPLSQVKLGQEYELVLTTFTGLYRYRLGDVVEVTSFHKGTPKLSFIYRRKLILTINIDKNTEKDLQRVVDKASQLLSRSTRAEVVDFTSHADVIARPGHYVIYWEIRGEADDKALEECCREMDTAFVDYGYVVSRRMNSIGPLELRVVERGTFGKVAERCVGKCGGLNQFKTPRCTTNSVMLDILNDSTIKRFRSSAYD
Protein: UPF0167 protein Rv2295 (P9WFL7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probably plays a role in host phagosome maturation arrest.
Interaction partners:
Sequence:
MPVEETSTPQKLPQFRYHPDPVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTDAMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALDALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA
Protein: Alpha-1,3-mannosyltransferase, putative (Q38AV3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- Mannosyltransferase
- Mannosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- GDP-Man:Man
- Dolichol phosphate-mannose biosynthesis regulatory protein
- GPI mannosyltransferase 1
- GPI mannosyltransferase 3
Sequence:
MEYRWLNRVLTVELCMSIIAFHLVHFTGIDWNAYMQEVKGFLDGELDYMKLKGDTGPLVYPGGFVWSHSALYFMTKGGVDVEMAQWLYLGIYVMVLVLVAHLYYNSGLRGRLFIRLLLSKRIRSLFMFRLFNDCWAMFLVYLSVICFARGRRWTVGCLLYSMAVSVKMNIFLFAPGLLLILCKSLPFTGVVRCLAVCALWQVVAGLPFLLHNPRSYIVRSFDLGRVFTYRWTVNFKRISEEIFFSSKFSRSLLVMLAVSWLLVCFRRWSKRAYRRGRCEKREGTVVLVGASDEEVFHNVTLTLMESNMIGVIFARSLHYQFFLWFFYFVPFVLSATRLPLVVKVVAFLAIQYGFEVYPSTTASSSVLLSGFLCVWLGMLLFPSEYSETTGKETTITLTAVKRGK
Protein: Conserved protein (O53157)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible nitrogen fixation related protein
- Probable cysteine desulfurase
- Probable conserved ATP-binding protein ABC transporter
- Iron-sulfur cluster assembly SufBD family protein Rv1462
- Iron-sulfur cluster assembly SufBD family protein Rv1461
- Probable transcriptional regulatory protein
- Alpha-
- Probable unidentified antibiotic-transport integral membrane ABC transporter
- Probable unidentified antibiotic-transport ATP-binding protein ABC transporter
Sequence:
MSETSAPAEELLADVEEAMRDVVDPELGINVVDLGLVYGLDVQDGDEGTVALIDMTLTSAACPLTDVIEDQSRSALVGSGLVDDIRINWVWNPPWGPDKITEDGREQLRALGFTV
Protein: Caskin, isoform D (A0A0B4LFD7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHRSLKPHASTAQAKKVQPPTIPGDSPQDLHLYQQPQQLHHHHHQHPNHHHPHHQPSIPLYRLSGPLRHHQNHQADDGISMSGSSIVSSPSLEEGGFNLPRETSVALRLKDEVGGTSTAAPTTGGPGGGGATVVGAPPPGAGKPGVAMVPPPPVFCATLREPLTHKAAVYYHQQLALQEDQGIDLTQSPGRDSPGSSSGSAGSGSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSPRCSSVSSCSIGSVDRQRNDELIIDWLLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQVRQPRGKSLESLEDIHDNSTRSHLTFSHYTTTDYGHFGPPTTAAAAAAMAAAATLQQQHHHQQLLHQQQQQAAAARLLGNNAPGIGWRRSYDDGDITPTNDATRELLYEQEGGGTLPRQQRGILQRAVLNTMPPLEHHHYMNAAAAAEYGAASGVEGGANYMGGSPLTGKKIAPEPPRRHCSIRNSRTLSGEGVPSGAAAQAHQQAAQQQQGQHMFYGHTAQHWQQQQQQAGAGTGQQPIYANYATIQQTTAEIHCEKYHDSKSTSSIDSIDTIPFANENTGTIKQRLLNRQELQGGGAGNNNVPGGGHPAHLHSSSSSSSSSSTNTIANIAHSFHSLKSSSSLHDATLARSESMGSTASGGSALHLRSPTLDMSNAGGSTAEPASSPEAAVPTVAINNGVPPKVSVNVLNDIGNMLANLTDELDAMLEEEKRVGLNIDSE
Protein: WD-40 repeat-containing protein MSI5 (Protein MULTICOPY SUPPRESSOR OF IRA1 5) (AtMSI5) (Q9SU78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Acts together with PDP1 and MSI4/FVE to regulate the function of the PRC2 complex on FLC.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O22607, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Histone-lysine N-methyltransferase EZA1
- Histone acetyltransferase type B catalytic subunit
- Histone-lysine N-methyltransferase MEDEA
- Lysine-specific demethylase ELF6
- Histone H4
- Polycomb group protein EMBRYONIC FLOWER 2
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- WD-40 repeat-containing protein MSI4
- Histone deacetylase 6
Sequence:
MESEAAATVQATRPRRAPRTPVTAILTDKRRRKPKSNNESQLPFLLQQSQKATVDDTYSQWKTLLPILYDSFVNHTLVWPSLSCRWGPQLEQAGSKTQRLYLSEQTNGSVPNTLVIANCETVNRQLNEKAHSPFVKKYKTIIHPGEVNRIRELPQNSKIVATHTDSPDILIWNTETQPDRYAVLGAPDSRPDLLLIGHQDDAEFALAMCPTEPFVLSGGKDKSVILWNIQDHITMAGSDSKSPGSSFKQTGEGSDKTGGPSVGPRGIYNGHKDTVEDVAFCPSSAQEFCSVGDDSCLMLWDARTGTSPAMKVEKAHDADLHCVDWNPHDNNLILTGSADNTVRVFDRRNLTSNGVGSPVYKFEGHRAAVLCVQWSPDKSSVFGSSAEDGLLNIWDCDRVGKKSERATKTPDGLFFQHAGHRDKVVDFHWSLLNPWTIVSVSDNCESIGGGGTLQIWRMSDLIYRPEDEVLTELEKFKSHVFTCTSKS
Protein: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein) (O95263)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Interaction partners:
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
- GTP:AMP phosphotransferase AK3, mitochondrial
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenosine kinase
- Adenylosuccinate lyase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Adenine phosphoribosyltransferase
- Deoxycytidine kinase
- F-actin-capping protein subunit beta
- cAMP-dependent protein kinase type I-alpha regulatory subunit
Sequence:
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Protein: Kank, isoform G (A0A0B4JCT6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLVLRSQRAFIEENARPIASSANPAPAGITRSVRSCNCCPYGYHIDLDFVRYCEALALEKPSEEEQRRRDRRRSRKSMEFMLGFESLFGGDWQAESRVQGKLSETSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYGSIPPRSESPFGTASSTCSSLRGGVESDAGIYHQRHRPAISPPETRAFLHEALDEVCSDFERTLERTSVKRRKSPYGAGSLSMDRNNNKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGNQSPTGTPRPFLRSNTLPLRQRPSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQENGSVSSSSLQSPVISETGQTTADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSPPSPGLKTASPVQFTPQRISPVSLESLGARMRSSSTSASPSPSVVRRDVSTQAVVRPPATRDVSVGHQPTTRNVGVQPSETVYSKEELDKKVEQALTNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTTPERPKLKYHVGVTVKPATRENFTSCKPDVRHVGSSDDRLDDVLCEKCAVSKRSVACGPETPAEKVKPAPQMPGRSNTFSLGENETVSVVRKTIGCQTPVTLVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQRLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSACNTEEVRKRDVGCGDIVKPHISIACAANYCDSCKEAIQDLARGFSKASPTATRTGGAVRRSTSADSRIPRPKHLSSPSPVRKEFMRQNTYTLATPSPTPSPQVERKARLSSLQEKPPSVSSFQASEPLPESQSFIRQPQKDSLDLSLLGEDELIVREEKRVSISWSRDASPAPLMTSSGTTKSESPEQEPAMSSSSDSSPPIDVQIAQGARKKSSTPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSEPRKKTELSQSLKDALKIINDSLLKKLGAKPISSQSLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGDATRSSLISPPRHKRQPSQ
Protein: Heme oxygenase (Q8IJS6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MIRKIIILMFTFFSNIHNEKIYHHKQRRKFLKGPLGYLNRNVIQKKHYNLYAKKFINYKEIQIQRINDYRKRSGVDKNNINYNLRDTYNYHETHLFVRNEVLPTLAKIENENLKEKEKNKEIFRNINDYNSNFTRQTFLQFLMDLYNIFLKIDDLFLENKTYFSILIYNGPMQLTNHLYDDIIYVSSVVENSDDVSPSEYCMEYISHLENLCEENKLSFLAHAYVFYKNFHLSKEHLLKSICKYLNIIKKLKSSTYVADVENFEFCLNKMSRKWSRWEKDNFLASLHNATNKMMILTKHFEKVKS
Protein: Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein) (Q9NZQ8)
Organism: Homo sapiens (Human)
Function: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S5UH55}.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Polycystin-2-like protein 1
- Guanine nucleotide-binding protein G
- Polycystin-1-like protein 3
- ADP-ribose pyrophosphatase, mitochondrial
- Taste receptor type 1 member 3
- Taste receptor type 1 member 2
- Short transient receptor potential channel 1
- Calcium homeostasis modulator protein 1
- Taste receptor type 1 member 1
Sequence:
MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQLVAADHRGGLDGWEQPGAGQPPSDT
Protein: T3SS secretion switching protein SepD (Type III secretion system protein SepD) (Q7DB65)
Organism: Escherichia coli O157:H7
Interaction partners:
- T3SS secretion switching protein SepL
- T3SS component
- Lipoprotein
- Multiple point controller protein
- Type 3 secretion system secretin
- T3SS chaperone CesD
- T3SS secreted effector EspZ
- T3SS chaperone CesD
- T3SS component
- Lipoprotein
Sequence:
MNNNNGIAKNDCDWLTALDFVKDVNGSPTHLTFYIYQKNAFLHDFGNYWVLYIELSGDFRQVPTDTFIRLCNILAVSNEYKQMGIFLSNKKWYLCQIFHKDNNHRANMSKAIMQHTLASLLDKQFDKLEQLSSSDTMMPPTHLFSDIGRIV
Protein: Replicative DNA helicase (EC 5.6.2.3) (O67450)
Organism: Aquifex aeolicus (strain VF5)
Interaction partners:
- DNA primase
- DNA replication protein DnaC
- Chromosomal replication initiator protein DnaA
- DNA polymerase III subunit gamma/tau
- Protein RecA
- Beta sliding clamp
- Type 2 topoisomerase subunit A
- Bifunctional chorismate mutase/prephenate dehydratase
Sequence:
MQFVDKLPCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEYGNKLDFVLIKDHLEKKNLLQKIPIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESATSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSSRQEEVAEVSRNLKALAKELHIPVMALAQLSREVEKRSDKRPQLADLRESGQIEQDADLILFLHRPEYYKKKPNPEEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANLEALPEQPPEEEELSEIIETQEDEGFEDIDF
Protein: 60S ribosomal protein L3 (H7C3M2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XVCVVMAAVSLSPASARLNPRRIAAIPSWPAPGSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYK
Protein: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (P08178)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Phosphoribosylformylglycinamidine synthase
- Amidophosphoribosyltransferase
- N5-carboxyaminoimidazole ribonucleotide synthase
- Bifunctional purine biosynthesis protein PurH
- N5-carboxyaminoimidazole ribonucleotide mutase
- Phosphoribosylamine--glycine ligase
- Phosphoribosylglycinamide formyltransferase
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Formate-dependent phosphoribosylglycinamide formyltransferase
- Adenylosuccinate lyase
Sequence:
MTDKTSLSYKDAGVDIDAGNALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNCGVGMIIALPAPEVDKALALLNANGENAWKIGIIKASDSEQRVVIE
Protein: Uncharacterized protein, isoform M (A0A0B4LGR1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDASLEESMDSDGASSPITKTEATESPPEAGLNGNGSGSGSTSQETPNYGVAILKEKPSEAHRSKPFNAFSGRPIGEHTAQQQALQQQQLQQQQQPQQPQQQAPSGANGVTGPPEIWVETKAEDGRSYYYHAVTRETTWSRPDGPAVKIMTQAEVEEMAKRPAQAAKTEAKAGETSVEIPPVSSHLTSQPPPHLMSQPPPNAAAPLLSQPPPNVRQQPPPMFQPPGMQAPPGFGQPPFCMPPPTYGFPGGPAPAGAPWGVGIPPWQQQQHMQDKPAKSLIIKPGVIDPAVIARAAEWSEHRAPDGRPYYFHAGRGESVWEKPQALRDMEAARMAAHSGVAPAVATAPSGLPPHLLPNPMMHMPPGSGPPGFDPHAAFAAAAAAMKANSENTKAAQAAALEKEAKKAAEEKRKKEEEQKKAAASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNPSTRTSVWDRPEDLLNREDVDKAVNERPEQLKTPQEKSAEAEQKSGEEANQEQAKSQVQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEEVPTKRVRMISKSKRAEDAALEAEQRAAKERALVPLEMRVTQFKEMLREKDVSAFSTWEKELHKIVFDPRYLLLTSKERKQVFEKYVKDRAEEERKEKRNKMRQKREDFRSLMEEARLHGKSSFSEFSQRNAKDERYRAIEKVRERESLFNEYIVEVRRREKEDKLLKKEQVGLGYAGAPYPITLRILMFKHKCISLYIYLITYPYAKRIYIM
Protein: Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) (Q9DCH4)
Organism: Mus musculus (Mouse)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit D
Sequence:
MASPAVPANVPPATAAAAPAPVVTAAPASAPTPSTPAPTPAATPAASPAPVSSDPAVAAPAAPGQTPASAPAPAQTPAPSQPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTGLQHGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
Protein: Small ribosomal subunit protein eS27-like (40S ribosomal protein S27-like) (Q6ZWY3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
Protein: Ankyrin repeat domain 2 (Q5T457)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
Protein: Zinc finger protein 155 (Q12901)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 222
Sequence:
MTTFKEAVTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGHQPFHQDTCHFLREEKFWMMGTATQREGNSGGKIQTELESVPEAGAHEEWSCQQIWEQIAKDLTRSQDSIINNSQFFENGDVPSQVEAGLPTIHTGQKPSQGGKCKQSISDVPIFDLPQQLYSEEKSYTCDECGKSICYISALHVHQRVHVGEKLFMCDVCGKEFSQSSHLQTHQRVHTGEKPFKCEQCGKGFSRRSALNVHRKLHTGEKPYICEACGKAFIHDSQLKEHKRIHTGEKPFKCDICGKTFYFRSRLKSHSMVHTGEKPFRCDTCDKSFHQRSALNRHCMVHTGEKPYRCEQCGKGFIGRLDFYKHQVVHTGEKPYNCKECGKSFRWSSCLLNHQRVHSGEKSFKCEECGKGFYTNSQLSSHQRSHSGEKPYKCEECGKGYVTKFNLDLHQRVHTGERPYNCKECGKNFSRASSILNHKRLHCQKKPFKCEDCGKRLVHRTYRKDQPRDYSGENPSKCEDCGRRYKRRLNLDILLSLFLNDT
Protein: Leucine-rich repeat protein FLOR 1 (Protein FLORAL TRANSITION AT THE MERISTEM 4) (Q9LH52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes flowering transition in long days (LD).
Subcellular location: Cytoplasm {ECO:0000269|Ref.7}. Nucleus {ECO:0000269|Ref.7}. Cytoplasm, perinuclear region {ECO:0000269|Ref.7}. Cell membrane {ECO:0000269|Ref.7}. Note=In carpels, observed both in cytoplasm and nucleus, as well as in the perinuclear and cell membrane in a vesicle-like pattern. In style cells, present in cytoplasm as well as in nucleus possibly in the perinuclear membrane. In leaf tissue, observed in the plasma membrane and in the perinuclear membrane. In roots and tapetum cells, restricted to the cytoplasm. {ECO:0000269|Ref.7}.
Interaction partners:
- Small GTPase-like protein LIP2
- AGAMOUS-like 58
- Zinc finger CCCH domain-containing protein 52
- Probable 2-carboxy-D-arabinitol-1-phosphatase
- Ras-related protein RABC2b
Sequence:
MKLFVHLSIFFSILFITLPSSYSCTENDKNALLQIKKALGNPPLLSSWNPRTDCCTGWTGVECTNRRVTGLSVTSGEVSGQISYQIGDLVDLRTLDFSYLPHLTGNIPRTITKLKNLNTLYLKHTSLSGPIPDYISELKSLTFLDLSFNQFTGPIPGSLSQMPKLEAIQINDNKLTGSIPNSFGSFVGNVPNLYLSNNKLSGKIPESLSKYDFNAVDLSGNGFEGDAFMFFGRNKTTVRVDLSRNMFNFDLVKVKFARSIVSLDLSQNHIYGKIPPALTKLHLEHFNVSDNHLCGKIPSGGLLQTFEPSAFAHNICLCGTPLKAC
Protein: Golgi integral membrane protein 4 (F8W785)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM