Protein: Serine/threonine-protein kinase ATM (EC 2.7.11.1) (Telomere fusion protein) (Q5EAK6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV.
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere.
Interaction partners:
- Serine/threonine-protein kinase ATR
- Nibrin
- PAX-interacting protein 1
- Double-strand break repair protein
- Histone acetyltransferase Tip60
- P53, isoform B
- DNA repair protein RAD50
- Breast cancer type 2 susceptibility protein homolog
- Rad17
- ATP-dependent DNA helicase II subunit 2
Sequence:
MSALLNEIQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKLFLSKTSDISWTTIFEASKEALFKQAGNLEDVNEKVFKTLAGKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSAFEDGIKMRVVVKYFGDRILSLLEKGIYSSVSYVRDLKINEYSRILSYLFELNVDMDEVLRTRILKCITRTVSLAKDRVQLHVDLVEYLPELSSFALSAFGARKTEIVRVYLIFASELAVNYNHQLNVHMQEILPKLCEYHDEDAFRDDTRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLKTIVNVEIRKNSWARCKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLRNLRLCLAHLLTKEQELLHSKSIREDFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQLICFDKDYATPFESITHIQSETKNCLIQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTYTGCPLIKRIGLYLSHIEFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLVLLDYLERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDDMLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTAKFITMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSLFQFDPKTHEGLVSVAIQVVNSKPGSNIMERYKNLRIFADKSTASTFLHSNKQIRRIDWLSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDILMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILDYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQFDKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDPHL