wanglab/gogpt-training-data huggingface dataset:
Protein: Actin-like protein arp5 (Q9Y7X8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable actin-related protein 8
- RuvB-like helicase 1
- RuvB-like helicase 2
- Chromatin-remodeling complex subunit ies6
- Chromatin-remodeling ATPase INO80
- Actin-related protein 4
- INO80 complex subunit 4
- INO80 complex subunit 3
- INO80 complex subunit 1
- SWI/SNF and RSC complexes subunit arp42
Sequence:
MKIYAVREPVFSGPTPSFQNVSNDIPLVIDNGSWQLRAGWGGEKDPKLVFDNLVSRYRDRKLSRTSTLVGNDTLIEVGSRSIARSPFERNVISNWDLMEQVLDYTFLKLGIDRMEHPICMTEPLANPTYVRSTMTELLFELYNAPSVAYGIDGLFSFYHNTKPSSSGIVLNLGNAASHVIPVLNGERILSEAKRISWGGSQSSSYLLKLFQIKYPSFPIKMLPSQAELLMHDHCHVSSDYTHDIAHALDRDILERDEIVLQFPYTEAAAQEKSQEELELIAERKRESGRRLQAQAAIKRKEKAAERDRELATLTELQQQSLVLSRRAFQRALEEAGFEDESQLNAQVKNVQAKIRRAQRDQQRQEESEGSLDVTEIDVEQAFPLLNVPDAELDEAGLRQKRHQRLMKANYDARVRAKAEKAIEEAAEAERAEADERLRLENFSTWVNEKRETHKILLEKISKNKRLKFELNDRKSHASQMRMKSLATLASEQPIQKRKRKDQSEDNFGARDEDWKVYHDVLTAEQLEEERKKLLDQIYSLEKQLLEYDSQFTQANTYDTLNDPRATLLYAFTRGVSDFDVNDVAQAFQLHLNVEQIRVPEVIFSPSIVGIDQAGILEIMRSILQRHSLEEQQKLVSNVLITGGLGSLPGMETRIKRELTSIMPVGSSINVFRASNPLLDAWKGASEWSVTEKFKAAKVTREEYLEKGPEYIKEHSLGNINS
Protein: Histone acetyltransferase subunit NuA4 (Q38FN2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGRGHGRGRGVAAPPGSKREVKASSALAEPQENGTATAQSQLQYLQARREAIERQLEGLDVCVYDLETTYLRHYVELGGCLFDGFGLERQQLWCTATATATATSTSASTTASSSSLGTALDARVAAYRERLHRFTPSDRIFTASSVGALGTVERVKTLEAAQEEAEATKRTRKRARGKG
Protein: Meiotically up-regulated protein PB1A10.08 (Q9HDY2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May have a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Barrier septum.
Interaction partners:
Sequence:
MMTRMELRPLEIGFSKALTEVAPVTCQCECWDHNLCSSQASEMDLIYQSQDTHSCASKQDAVFQLLSETKIPVPNRYRKISHRLSTLSNKKTLKSQLDRFLSSSKKLHNDDVNRGDYCFLLSTPVECSASTNSHSYDCLWNFSCNSFPEYSSYSASETSSVASYSYYSGPNPATPSSSSCNLVNANSLDIYLNINNLKKSKSVPRLRGQFMEPVEHNHPLSKSLEEQSSFLEQSKDASSNLTACNRSGSSLSSNFYSSRLSKKTSLASLNKSRASLQHKIMSLSRNIIRRVFHKPEVHLDPSASILNLSSSHGESNLTNGLLCQNFKLFQDDWLMEDCAPDANFTLYTPLQPWEKRSVKPEIRRPRLNPNFFRVFVLEAQMRRAGKLSANTAGRAQLIYLPKPAVTFSTSPLHVEL
Protein: Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) (O43306)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17110384}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q01341}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q01341}.
Interaction partners:
- Rap guanine nucleotide exchange factor 4
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 5
- Adenylate cyclase type 9
- Rap guanine nucleotide exchange factor 3
- Adenylate cyclase type 4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 3
Sequence:
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
Protein: TOM1-like protein 6 (O80910)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a gatekeeper for degradative protein sorting to the vacuole. Plays a role in recognition of ubiquitinated PIN2 auxin carrier at the plasma membrane and further to its endocytic sorting. Binds ubiquitin in vitro. Might contribute to the loading of the ESCRT machinery (Probable).
Subcellular location: Endosome, multivesicular body {ECO:0000269|PubMed:22639582}. Cytoplasm {ECO:0000269|PubMed:22639582}. Early endosome membrane {ECO:0000269|PubMed:24316203}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Protein PHOX1
- Protein ELC
- Protein ELC-like
- Vacuolar protein sorting-associated protein 22 homolog 1
- non-specific serine/threonine protein kinase
- Vacuolar-sorting protein BRO1
- Serine/threonine-protein kinase AFC1
Sequence:
MASSSASATVAVDKATSDLLLGPDWTTNMEICDSVNSLHWQAKDVVKAVKKRLQHKSSRVQLLALTLLETLVKNCGDYLHHQVAEKNILGEMVKIVKKKADMQVRDKILVMVDSWQQAFGGPEGKYPQYYWAYDELRRSGVEFPRRSPDASPIITPPVSHPPLRQPQGGYGVPPAGYGVHQAGYGVPQAGYGIPQAGYGVPQAGYGIPQVGYGMPSGSSRRLDEAMATEVEGLSLSSIESMRDVMDLLGDMLQAVDPSDREAVKDEVIVDLVERCRSNQKKLMQMLTSTGDDELLGRGLDLNDSLQILLAKHDAIASGSPLPVQASGSPLSVQASKPADSSPKSSEAKDSSSIAGSSSPIPATVSTGKSPIDEEYEEEEDEFAQLARRHSKPPASVTTDPTSLESHNAASNALALALPDPPPPVNTTKEQDMIDLLSITLCTPSTPPAPSSQPSPPPPAGSDQNTHIYPQPQPRFDSYVAPWAQQQQPQQPQAQQGYSQHQQHQQQQGYSQPQHSQQQQGYSQLQQPQPQQGYSQSQPQAQVQMQPSTRPQNPYEYPPPPWASTSANAYYTPRANASASYTDTSALAGRSLQQSNSFPTRAGDPQATSTASNSGVSVGQKPFVPSYRLFEDLDVFGSADGKHNKPANSSNGSQNLSGSQTQQSMIGGRKMI
Protein: F3I6.9 protein (Triadin) (O48683)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g65207
- Probable calcium-binding protein CML16
- F18C1.18 protein
Sequence:
MGDMQVGVATIDDKGFYGLMEDTQVKAVASSNPSLQVSVSFGRFENDSLSWEKFSAFSPNKYLEEVGKCATPGSVAQKKAYFEAHYKKIAERKAEIIDQEKLMDENASFRSIVSDQESVECENGGVVVESEVDNGCNGQLSCDEDKHVTDITAKVNQVSIDESNEETIVVKECQSSVDTVKDEVKDSVDSPVLEKAEEIALEEEKIEMVVHVQERSEEVLQEDEKEETEVREEVRDDISLQNDTVDANETTKKVVKKEKKPNLIKKNDGNVRINPTRGSLKPNQVGGKPETNKTVTSRKTPPSKEMKNMMKATKKPAAPMSKSPQGFATPRVYKPAPTKTSLSTSHSSLKKEKVSPLLSKKQTAPKSLHISMNLDPPASDPTALPSTRKSLIMERMGDKDIVKRAFKSFQKSFDFKSSVDGLNTAVKQNPAKPTIIPSVATRQKENGRPTKASSMEKRSGTTAYRSPSHGLKSNETAEKQQKEISKSGARPLEKTRLQKNPKAGVIDAKTRRDSLNPKAKPVQGSLPMRTVSKSSLDKVL
Protein: Probable endoribonuclease MazF7 (EC 3.1.-.-) (Toxin MazF7) (P0CL62)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7. Probably an endoribonuclease (By similarity).
Interaction partners:
- Antitoxin MazE7
- Antitoxin MazE9
- Precorrin-3B synthase CobG
- Precorrin-8X methylmutase
- Antitoxin MazE3
- Cobalamin biosynthesis protein CobIJ
- Ribonuclease VapC10
- Ribonuclease VapC46
- Probable endoribonuclease MazF1
Sequence:
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGVRAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP
Protein: HrpX protein (A0A0H2X9M1)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Interaction partners:
Sequence:
MILSTYFAAISALSYADRLPIYTSRMLVGAWPQGLQHLQQRREGQAAPDGSDDEVALLGASADALLILEYQEEAEDAYRQASKAMRGHQRQLRLLSCRNTAWLMLSQRRLSAALNCFAQLAMDRDTPAVLCGESLLGKALTHFHLGQSTLALQTLERAQEVVSELELGAADWTRVVGALRLDLIAQLRIRRGERMSDHVFWQATLRQEDAAHTFEASELRACIADLSESMPVLAQRMRHVRNLLRIAGGDIFGFDAQIDALPAAATGCPPCARQDAQVELALAALAVGRADLAERALAGAGRHHAPRWNLEFEYCQAKISQALGRAEQALLLYNRYALGAVQCLRSEVQAPRLLESGTPAHVSDDISARLPAKYRRAYAYMITNAHRSDLSINEVAAQIGVTGRALQQAFKSATGLSPTQVLRRYRMQGIRDELLADGGCGSVLQAASRWGVGSRSALAKGYRQHFNEAPMETLQR
Protein: CDKN1A interacting zinc finger protein 1 (F7AT58)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
PPPKRWCNTCQVYYVGDLIQHRRTQEHKVAKQSLRPFCTICNRYFKTPRKFVEHVKSQGHKDKAQELKTLEKETGSPDEDHFITVDAVGCFESGQEEDEDDDEEEEEEGEIEAEEEFCKQVKPRETSSEQGKGSETYNPNTAYGEDFLVPVMGYVCQICHKFYDSNSELRLSHCKSLAHFENLQKYKAKNPSPPPTRPVSRKCAINARNALTALFTSSHQPSPQDTVKMPSKRPR
Protein: Uncharacterized protein C06E1.1 (P34296)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MATIIAKIESKINEYLKARNKEDWKEKTFTQAEKFSGIPRERIVSMAFLMLSIYVLLGNFLPLFSHIICIFWPVKESFMILRQQKNPSDNILLYWILYAMVSLFDYSALPGVPFYYFAKTGLFLSITTNGFDKLKEWSEPALKFTETWVLVTPPPPGEEEN
Protein: Actin-interacting protein 1 (DAip1) (WD repeat-containing protein 2 homolog) (P54686)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Implicated in both actin filament depolymerization and polymerization. May enhance chemotaxis by promoting cofilin-dependent actin assembly at cell leading edges.
Subcellular location: Cell projection, phagocytic cup {ECO:0000269|PubMed:10427097}. Cell projection, lamellipodium {ECO:0000269|PubMed:10427097}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10427097}. Note=Localizes to dynamic regions of the cell cortex that are enriched in filamentous actin and rapidly redistributes to newly formed cortical protrusions.
Interaction partners:
- F-actin-capping protein subunit beta
- Actin domain-containing protein
- Cofilin-1A
- Adenylyl cyclase-associated protein
- F-actin-capping protein subunit alpha
- Actin-related protein 3
- Cofilin-1B
- Coronin-A
Sequence:
MSVTLKNIIAPTPATTRGKSVAINGDPKGENIVYASGSSIIIRNVKNPMVADIYYEHPCQTTVAKYAPSGNYIASGDVQGNLRIWDTLQKEHILKATYKVLNGAILDIAWTSDNQRLVVVGDGKERFGAAILWDSGSSCGEITGHSKMILSCDIKSTRPFRAATGSEDFAVNWFEGPPFKFQKNIAAGDFTRFVNCVRFSPDGNKLVTVGADKKAFVYDGKTGEKLIELNPAQQHTGGIYGCSWSADNNRVLTASADKSCKIWDTTTGQCINSFTFGSDVNDQQLGCLWFGDSLLSVNLAGEISTLNLDDVAKPSRVIKGHNKLVGTIAFDKNAGSLYSASYDASLLQWDLSTGLATNFTGPAHKNQITSIKINGDQLITCAMDDSVKISSISKKTYGESIGVDSPAQAVAFSGDVVVAVSMKTIYVIKGGKIVSQTAATWEPTSVAINDTEVSVGGKDNKIHVFTLSGNNLTASHTLDNHRGAITDLSYSPCGKYLASGCSNREVIVWSGKEAKSKGWVNHTARINAVAWSNDSKFVASASLDSQIYIWNVENPTASPVQVKNSHLGGVNDVIYGSNNEIFSAGNEGAIKIWNVSN
Protein: Ubiquitin carboxyl-terminal hydrolase MINDY (EC 3.4.19.12) (K7N7A8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
XETLTLHSLTCYEDLVTFLQQSIHQFEVGPYGCILLTLSAILSRSTELIRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGDGNITLLRGIAARSDIGFLSLFEHYNMCQVGCFLKTPRFPIWVVCSESHFSILFSLQPGLLRDWRTERLFDLYYYDGLANQQEQIRLTIDTTQTISEDTDNDLVPPLELCIRTNIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
Protein: Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-) (P83111)
Organism: Homo sapiens (Human)
Function: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941, ECO:0000269|PubMed:19858488, ECO:0000269|PubMed:28329758}.
Interaction partners:
- NSFL1 cofactor p47
- UBX domain-containing protein 2A
- Protein phosphatase 1L
- Integrator complex subunit 9
Sequence:
MYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGLGLGLGLALGVKLAGGLRGAAPAQSPAAPDPEASPLAEPPQEQSLAPWSPQTPAPPCSRCFARAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMMKENVAFEQEKEGKSNEKNDFTKFKTEQENEAKCRNSKPGKKKNDFEQGELYLREKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGCKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVERKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDTETINNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRSD
Protein: Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) (P10073)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Interaction partners:
- Zinc finger and SCAN domain-containing protein 32
- SCAN domain-containing protein 1
- Zinc finger and SCAN domain-containing protein 20
Sequence:
MAIPKHSLSPVPWEEDSFLQVKVEEEEEASLSQGGESSHDHIAHSEAARLRFRHFRYEEASGPHEALAHLRALCCQWLQPEAHSKEQILELLVLEQFLGALPPEIQAWVGAQSPKSGEEAAVLVEDLTQVLDKRGWDPGAEPTEASCKQSDLGESEPSNVTETLMGGVSLGPAFVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGRESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSGKRSSKCRECRKMFQSASALEAHQKTHSRKTPYACSECGKAFSRSTHLAQHQVVHTGAKPHECKECGKAFSRVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQSTHLTQHQRIHTGEKPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAFSRSSALMVHLRIHITVLQ
Protein: Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (A7E3N2)
Organism: Rattus norvegicus (Rat)
Function: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSLAEAIRLWNEGVQAADKKDWKGALEAFSEVQDPHSRICFNIGCMYTILDNLQEAEQAFTKSINRDKHLAVAYFQRGMLYYSMEKYRPASVGRKAALLFLGSYNLVARIIVGYPLSPGKVLYNIALMHAKKEEWKKAEEQLALATNMKSEPRHSKIDKAMESIWKRCPTSHLPLDPPQVTMALWFEEGGVGKRSVVASVVHQDNFSGFAPLQPQSAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGSDNWATVMFNGQKGLVPCNYLEPVELRIHPQSQPQEDTSLESDIPPPPNSSPPERLQLSPGWCQQLGPLRCPPFLLHQEVKRSVPMPYMLKVHYKYTVVMETQLGLPYSQLRNMVSKKLELLPEHTKLSYQRRDSPELLLLSEESMKDAWAQVKNYCLTLWCEHTVGDQGFVDEPKEKENSDADNRTTEPQPKEGTQVVAIFSYDATQPEDLEFVEGDVILVLSHVNEEWLEGECKGKIGIFPKAFVEGCAAKNLEGTPREV
Protein: Neuromodulin (Axonal membrane protein GAP-43) (Calmodulin-binding protein P-57) (Growth-associated protein 43) (P06837)
Organism: Mus musculus (Mouse)
Function: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Synapse {ECO:0000250|UniProtKB:P17677}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}. Perikaryon {ECO:0000250|UniProtKB:P07936}. Cell projection, dendrite {ECO:0000250|UniProtKB:P07936}. Cell projection, axon {ECO:0000250|UniProtKB:P07936}. Cytoplasm {ECO:0000250|UniProtKB:P07936}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. {ECO:0000250|UniProtKB:P17677}.
Interaction partners:
- Calmodulin-like protein 4
- Neural cell adhesion molecule 1
- Synapsin-1
- Calmodulin-4
- Calmodulin-like protein 3
- Calmodulin-1
- Calmodulin 5
- Beta-nerve growth factor
- Synaptophysin
- Acyl-protein thioesterase 2
Sequence:
MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAATKAAQPPTETAESSQAEEEKDAVDEAKPKESARQDEGKEDPEADQEHA
Protein: NK13 (Serine (Or cysteine) peptidase inhibitor, clade B, member 6B) (O08804)
Organism: Mus musculus (Mouse)
Interaction partners:
- Cathepsin G
- Albumin
- Serine
- Serine
- Serpin B6
- Thyroglobulin
- T-cell surface glycoprotein CD4
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-4
- Caspase-1
Sequence:
MDPLLEANATFALNLLKTLGEDSSRNVLFSPISVSSALAMVFMGAKGTTASQMAQALSLDKCSGKGGRDVHQGFQSLLTETNKTGTQYVLRTANRLFGEKTFDILASFKDSCRKFYEAEMEELDFKGATEQSRQHINAWVAKKTEDKITELLSSGSVNSNTPLVLVNAIYFKGNWEKQFNKEDTQEMPFNVTKDVVKPVQMMFQKSTFKMTYVEEISTNILLLPYVGNELNMIIMLPDEHIELSMVEKEITYKKFIEWTRLDKMEEEEVEVFLPKFKLEENYDMKDVLCRLGMTDAFEEGMADFSGIASKEGLFLSKVIHKSFVEVNEEGTEAAAATAANIGFRCMVPYFCANHPFLFFIQHSRTSGIVFCGRFSSP
Protein: Activator of basal transcription 1 (Q9QYL7)
Organism: Mus musculus (Mouse)
Function: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:10648625}. Nucleus, nucleolus {ECO:0000269|PubMed:10648625}.
Interaction partners:
- Ribosomal RNA processing protein 36 homolog
- U3 small nucleolar RNA-associated protein 25 homolog
- KRR1 small subunit processome component homolog
- Probable ATP-dependent RNA helicase DDX10
- Probable ATP-dependent RNA helicase DDX49
- Bystin
- U3 small nucleolar RNA-associated protein 18 homolog
- Nucleolar protein 14
- ESF1 homolog
- U3 small nucleolar RNA-associated protein 6 homolog
Sequence:
MVKAGELVEQQKAAMEEEANAEAAEDQEEPEDTACSSSSKKKKKVVPGIVYLGHVPPRFRPLHVRNLLSAYGEVGRVFFQAEDHFVKRKKKAAAAAGGKKGAKYSKDYTEGWVEFRDKRVAKRVAASLHNTPMGARKRSPFRYDLWNLKYLHRFTWSHLSEHLAFERQVRRQRLRAEVAQAKRETDFYLRNVEQGQHFLAADGDATRPNSSWTFTQRPTEQEFRARKAARPGGRERARLANVEDQARSNRGLLAKIFGAPLPAESKEKP
Protein: RAN binding protein 9 (A0A8I5Y176)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGQPPPPPPQQQPPPPPAAGAPGSGVALPAPAAASAGSSPAGSPGGGLGAAAAALLLHPPPPPPPPPATAAPPPPASAAAPATAPPGLAVGPGSVAGVPVPGLAAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMSIHSLAPGKGSTAHFPGFESCSNGVISNKAHQSYCHSKHQLSSLNVPELNSINVSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDCSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRECGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARAGVGSCAFATVEDYLH
Protein: Cecropin-D-like peptide (P85210)
Organism: Galleria mellonella (Greater wax moth)
Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. Has antibacterial activity against the Gram-positive bacteria M.luteus (MIC=34.4 uM), L.monocytogenes (MIC=34.4 uM), and S.lutea (MIC=34.4 uM), and the Gram-negative bacterium E.coli D31 (MIC=8.6 uM). Lacks antibacterial activity against the Gram-positive bacterium B.circulans, and the Gram-negative bacteria E.coli ATCC 25922 and S.typhimurium. Has antifungal activity against A.niger, but lacks antifungal activity against C.albicans, C.wickerhamii, F.oxysporum, P.pastoris, P.tannophilus, S.cerevisiae, T.harzianum, and Z.marxianus.
Subcellular location: Secreted {ECO:0000269|PubMed:11995991, ECO:0000269|PubMed:17194500}.
Interaction partners:
Sequence:
ENFFKEIERAGQRIRDAIISAAPAVETLAQAQKIIKGGD
Protein: Cation/H(+) antiporter 17 (Protein CATION/H+ EXCHANGER 17) (AtCHX17) (Q9SUQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Operates as a K(+)/H(+) antiporter that controls K(+) acquisition and homeostasis.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- F-actin-capping protein subunit alpha
- Sodium/hydrogen exchanger 1
- Sodium/hydrogen exchanger 8
- Potassium transporter 5
Sequence:
MGTNGTTCPGPMKATSNGVFQGENPLEHALPLLILQICIVLLLTRLLAFLLRPLRQPRVIAEIVGGILLGPSALGKSTKFINTVFPPKSLTVLDTLANLGLIFFLFLVGLELDPKSLKRTGKRALSIALAGITLPFVLGIGTSFALRSSIADGASKAPFLVFMGVALSITAFPVLARILAEIKLLTTDIGKIALSAAAVNDVAAWILLALAVALSGEGSSPLTSLWVFLSGCGFVLFCIFVVQPGIKLIAKRCPEGEPVNELYVCCTLGIVLAASFVTDFIGIHALFGAFVIGVIFPKEGNFANALVEKVEDLVSGLFLPLYFVSSGLKTNVATIQGAQSWGLLVLVIFNACFGKIIGTVLVSLYCKVPLDQSLALGFLMNTKGLVELIVLNIGKDRGVLNDQIFAIMVLMAIFTTFMTTPLVLAVYKPGKSLTKADYKNRTVEETNRSNKPLCLMFCFQSIMNIPTIVNLIEASRGINRKENLSVYAMHLMELSERSSAILMAHKVRRNGLPFWNKDKSENNSSSSDMVVVAFEAFRRLSRVSVRPMTAISPMATIHEDICQSAERKKTAMVILPFHKHVRLDRTWETTRNDYRWINKKVMEESPCSVAILVDRGLGGTTRVASSDFSLTITVLFFGGNDDREALAFAVRMAEHPGISLTVVRFIPSDEFKPENVRIEITEDQLCSGATRLIDIEAITELKAKIKEKESSRSNSDSESHIIYEEKIVKCYEEVIEVIKEYSKSNLFLVGKSPEGSVASGINVRSDTPELGPIGNLLTESESVSTVASVLVVQQYIASRPVGISKNVTTEESLVEDSESP
Protein: Suppressor of glycerol defect protein 1 (Q06132)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in osmoregulatory glycerol response, probably through its interaction with PLC1 which regulates the expression of GDP1.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11042259, ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent RNA helicase FAL1
- rRNA biogenesis protein RRP36
- ATP-dependent RNA helicase HCA4
- KRR1 small subunit processome component
- RNA cytidine acetyltransferase
- U3 small nucleolar RNA-associated protein 12
- Something about silencing protein 10
- Ribosomal RNA-processing protein 9
- U3 small nucleolar RNA-associated protein 6
- Probable ATP-dependent RNA helicase DHR2
Sequence:
MQKTDGIRIPGVILDELKTLDYSQDERFSISEGKKRRRGNGKHLSRKEKRKMERADKKRKIISTREINSSRLKSAPTSEKRSANAGVKNVGKQANGKNPISSDESESNENWDSDEVLTDEVAEESGEQAMSAEETMKKLESLKRKAKGIQGAENSGEIKGNSYEKKHIRNRDTNENFVSYPLAPSDRSAFERDEMDMQYYAKKLGLKGERKAIHAKDEFDAIGGLLEGLEYFENYGKSDEEYGDFATETNSMRKDDEASEKAFSSDDDLSASDFEDSDGLSESDNDSVADSDDNYRREKENPYVAPTQSVESYVPPSLRKKLDDSENNSTLSEISKKVNSSLNKLSDSNITIIITDLNRLYDSLPRQYVTESLTKGILNIISQNQKLLDGFIMNYAALAYTLSKLRGIEVGAFFIQKTVEAFLHHYEEEMENILKDQQSKISSKICINIATLLSYCYNFGFVSCRLIYDIIRIFVADPNEFTTELLLRIISISGQLIRGDDPSALRDIRSELLKNAKNLKEQSPRLRFLMDTMSDLKNNRLKPSILATDHHPLKKNLQSILNSSSSWEPLQVSLEDIKNIDSKGKWWLVGASWRGNMENAFEVSINNENDASKSKKSKISIEDDLLDDIPDWNIIARQQRMNTDIRRAIFISIMSAQDYLDAFSKLEKLSLKNKQVLEIPRIVLHCLLADSGSNGYNHYYALVANKICERYSHLSKSFQFLFWDVIKKFEDKEFDSESDTDEEDDLDDKEKLLRISNQGRFFGSLLANDILKLDVFKHVPFMGGLNTEGMLFMEILLFQLFLTVAKKSEKKLKMDESGNKRIIYSDDYLRDVLTKNVKSENMLFILKGLKWFINKKFRYHNFLAGKKGDKAFDRDERRLAWASKAAKSIIDKELENIDS
Protein: Apoptosis regulatory protein Siva (B4DTY2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR038096}. Nucleus {ECO:0000256|PIRNR:PIRNR038096}.
Interaction partners:
Sequence:
MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVE