wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 53 homolog (Q5VIR6)
Organism: Homo sapiens (Human)
Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.
Interaction partners:
- Syndetin
- Vacuolar protein sorting-associated protein 51 homolog
- Vacuolar protein sorting-associated protein 52 homolog
- Vacuolar protein sorting-associated protein 54
- Syntaxin-16
- Ras-related protein Rab-6A
- Syntaxin-6
- Vesicle-associated membrane protein 4
- EARP and GARP complex-interacting protein 1
- Conserved oligomeric Golgi complex subunit 4
Sequence:
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGAESSGSLSLTAPTPEQESSRIRKLEKLIKKRL
Protein: Sterile20-like kinase, isoform B (Sterile20-like kinase, isoform D (EC 2.7.11.-)) (Q9W179)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Moesin/ezrin/radixin homolog 1
Sequence:
MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQELNRQIKLAIDQHEKRFGLVTNREEFEDQEVKLPAHLRNIYNERSSRILPRNTFIDPQNMPRSRSSLLMMGGGGNRLSNFRGSAPDLSRSVPNTPIMHKQQRSQMIGDQVLEEDEEQMLSEQMKRASVATLPAQNQLRLITQLPANELVKVVTSTPPLNSAEDVNSKPSMSTFRGSTPPKTPDDLGLVTNRFSRLDTKAAAEASGVELRIHEGPVLTAHTQRLLHTTSFAIKRPSLASRSSGRSSLSSAQSMYNINELSTRFTSDADLIFDSGRKAAALLDEVQPQLRSSVKPGHSRANGSVVSADSAASSEDIYYDLYAAQYKLPRQLQQRLQQEVSPLIYPQCASQPFDTTQGPETGARRLEETFAQQLDEMETLYGGALIVSMPSDTLQRDHFTGSTRSSLSSYSEG
Protein: Increased sodium tolerance protein 2 (P38250)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in ion homeostasis together with BTN1 or BTN2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11030653, ECO:0000269|PubMed:15701790}; Multi-pass membrane protein {ECO:0000269|PubMed:11030653, ECO:0000269|PubMed:15701790}. Note=Correct localization requires BTN2. Localizes to the mother cell in small budded cells and to the bud in medium and large budded cells. Transported to the bud tip by an actomyosin based process. Compartmentalization maintained by a septin mediated membrane diffusion barrier at the mother-bud neck.
Interaction partners:
- Oxysterol-binding protein homolog 6
- SWI5-dependent HO expression protein 2
- Tricalbin-1
- SWI5-dependent HO expression protein 3
- Vesicle-associated membrane protein-associated protein SCS22
- Myosin-4
- Vesicle-associated membrane protein-associated protein SCS2
- Tricalbin-3
- Tricalbin-2
- Transcriptional regulatory protein ASH1
Sequence:
MSQTITSLDPNCVIVFNKTSSANEKSLNVEFKRLNIHSIIEPGHDLQTSYAFIRIHQDNAKPLFSFLQNLDFIESIIPYHDTELSDDLHKLISISKSKILEAPKQYELYNLSNLTNNPKQSLYFAFLQNYIKWLIPFSFFGLSIRFLSNFTYEFNSTYSLFAILWTLSFTAFWLYKYEPFWSDRLSKYSSFSTIEFLQDKQKAQKKASSVIMLKKCCFIPVALLFGAILLSFQLYCFALEIFIKQIYNGPMISILSFLPTILICTFTPVLTVIYNKYFVEPMTKWENHSSVVNAKKSKEAKNFVIIFLSSYVPLLITLFLYLPMGHLLTAEIRTKVFNAFSILARLPTHDSDFIIDTKRYEDQFFYFIVINQLIQFSMENFVPSLVSIAQQKINGPNPNFVKAESEIGKAQLSSSDMKIWSKVKSYQTDPWGATFDLDANFKKLLLQFGYLVMFSTIWPLAPFICLIVNLIVYQVDLRKAVLYSKPEYFPFPIYDKPSSVSNTQKLTVGLWNSVLVMFSILGCVITATLTYMYQSCNIPGVGAHTSIHTNKAWYLANPINHSWINIVLYAVFIEHVSVAIFFLFSSILKSSHDDVANGIVPKHVVNVQNPPKQEVFEKIPSPEFNSNNEKELVQRKGSANEKLHQELGEKQPASSANGYEAHAATHANNDPSSLSSASSPSLSSSSSSSKTGVVKAVDNDTAGSAGKKPLATESTEKRNSLVKVPTVGSYGVAGATLPETIPTSKNYYLRFDEDGKSIRDAKSSAESSNATNNNTLGTESKLLPDGDAVDALSRKIDQIPKIAVTGGENNENTQAKDDAATKTPLIKDANIKPVVNAAVNDNQSKVSVATEQTKKTEVSTKNGPSRSISTKETKDSARPSNNNTTTTTTTDATQPHHHHHHHRHRDAGVKNVTNNSKTTESSSSSSAAKEKPKHKKGLLHKLKKKL
Protein: Bifunctional nitrilase/nitrile hydratase NIT4 (EC 3.5.5.1) (EC 3.5.5.4) (EC 4.2.1.65) (Cyanoalanine nitrilase) (Nitrilase 4) (P46011)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Highly specific for beta-cyano-L-alanine (Ala(CN)). Low activity with 3-phenylpropionitrile (PPN) or allylcyanide and no activity with indole-3-acetonitrile. Not associated with auxin production but may be involved in cyanide detoxification.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Tightly associated with the plasma membrane.
Interaction partners:
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial
- Glutathione hydrolase 2
- Glutathione hydrolase 1
- Glutathione hydrolase 3
- Putative inactive glutathione hydrolase 4
- Probable isoaspartyl peptidase/L-asparaginase 2
- Isoaspartyl peptidase/L-asparaginase 1
- Glutamate decarboxylase 1
- Glutamate decarboxylase 4
- Glutamate decarboxylase 2
Sequence:
MSMQQETSHMTAAPQTNGHQIFPEIDMSAGDSSSIVRATVVQASTVFYDTPATLDKAERLLSEAAENGSQLVVFPEAFIGGYPRGSTFELAIGSRTAKGRDDFRKYHASAIDVPGPEVERLALMAKKYKVYLVMGVIEREGYTLYCTVLFFDSQGLFLGKHRKLMPTALERCIWGFGDGSTIPVFDTPIGKIGAAICWENRMPSLRTAMYAKGIEIYCAPTADSRETWLASMTHIALEGGCFVLSANQFCRRKDYPSPPEYMFSGSEESLTPDSVVCAGGSSIISPLGIVLAGPNYRGEALITADLDLGDIARAKFDFDVVGHYSRPEVFSLNIREHPRKAVSFKTSKVMEDESV
Protein: Liquid facets (Q9U741)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MQVNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYIDGPSQRDLPPGWQEEPPKSVSELEMVRPQTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRLQLALSQSEQDFKDPNGRPIPAPKKEEQQSHLLDLLDISLGATSISSPPLGAAGGAPTAVVDPWAMPGPRAPSQLSDPWSGTSSPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNGNANQNGRGATPAGPPAEGWLIKSTAVGALGAAPLNHAANNGSSSSDPWLAEPAASAAGGAAAVGLADPWAPGAASQTGAGALDDPWKALGTGAIKKQSPEFDEFDLITNRNKSEHSNSNASNNNNASLLDDMDPLSANYGNGGINSSMHPSTGATAKKSIKDAHSFLGENSALVNLDNLIKPIAPQTQTGNQPAYNPFSDNVVPPKTNLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPVMGGVSTTSQPQPNLQVYNNAYQSSSSTNILGKSNIPTNMNSSTSNSTIHSCYASPSPGVDGIRNMDIFTERPYYNSPTAPADDTYMYNSRDNNNINSNYGTPSLYSSFAASYSSALSDSLAETPGISVAPLGFVADTVMSFGPSSSSANCKLEQNNNMPWIKPEAATNPFLS
Protein: ATP-dependent Clp protease proteolytic subunit 5, chloroplastic (EC 3.4.21.92) (Endopeptidase ClpP5) (nClpP5) (nClpP1) (Q9S834)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity).
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:11982939, ECO:0000269|PubMed:14593120}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic
- Chloroplastic ATP-dependent Clp protease proteolytic subunit 1
- ATP-dependent Clp protease proteolytic subunit-related protein 3, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 4, chloroplastic
- 20 kDa chaperonin, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 6, chloroplastic
- ATP-dependent Clp protease ATP-binding subunit CLPT2
Sequence:
MAHACVSTSASSLRFTAGFVSASPNGSSFDSPKLSLPFEPLRSRKTNKLVSDRKNWKNSTPKAVYSGNLWTPEIPSPQGVWSIRDDLQVPSSPYFPAYAQGQGPPPMVQERFQSIISQLFQYRIIRCGGAVDDDMANIIVAQLLYLDAVDPTKDIVMYVNSPGGSVTAGMAIFDTMRHIRPDVSTVCVGLAASMGAFLLSAGTKGKRYSLPNSRIMIHQPLGGAQGGQTDIDIQANEMLHHKANLNGYLAYHTGQSLEKINQDTDRDFFMSAKEAKEYGLIDGVIMNPLKALQPLAAA
Protein: Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (BRK-3) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (O35607)
Organism: Mus musculus (Mouse)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q13873}; Single-pass type I membrane protein.
Interaction partners:
- Bone morphogenetic protein 4
- Bone morphogenetic protein 6
- Activin receptor type-1
- Bone morphogenetic protein 7
- Growth/differentiation factor 2
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein 10
- Growth/differentiation factor 9
- Bone morphogenetic protein 2
Sequence:
MTSSLHRPFRVPWLLWAVLLVSTTAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETHLHATNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDILTQGVTSTAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTTVSKDIGMNCL
Protein: Dapper homolog 3 (Dapper antagonist of catenin 3) (Q0PHV7)
Organism: Mus musculus (Mouse)
Function: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity).
Interaction partners:
- Dapper homolog 2
Sequence:
MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDAEEDEDAAAARRAAAALEEQLEALPGLIWDLGQQLGDLSLESGGLDQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSGSYGRLGPSDPRGIYASERPKSLGDASPSAPESVGARVAVPRSFSAPYPTAAAGAETCSSAERRARAGPFLTPSPLHAVALRSPRPSGRVPCGSPDGAASRPLDGYISALLRRRRRRGAGQPRTSPGGADGGARRQNGARPRPPEASPPPGGARPAREPSTERAWAAAWEAEVPPEPAPPAAASPPSSPAEGRLVKAQYIPGAPAASRGLPGRAARRRAPPLTRGRSVEQSPPRERPRAAGRRGRLAEPSGRRGSPRARKAARSQSETSLLGRAHAAPPPKYPTAERDEPRPPRPRRGPAPTPTVQACRRWRSTAEIDAPDGRRPRARVPAPRGPAPSPSAPPRRLLYGCAGSDSECSAVGRPVPLGRRMPSGCAPGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAAAGASPSGPGGAAGGGTPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV
Protein: NAD-capped RNA hydrolase NPY1 (DeNADding enzyme NPY1) (EC 3.6.1.-) (NADH pyrophosphatase) (EC 3.6.1.22) (P53164)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives.
Subcellular location: Peroxisome {ECO:0000269|PubMed:11361135}.
Interaction partners:
- Glutamine-dependent NAD
- Suppressor of disruption of TFIIS
- Nicotinate phosphoribosyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- IMP-specific 5'-nucleotidase 1
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Nicotinamide mononucleotide adenylyltransferase
- NAD-dependent histone deacetylase SIR2
- Nicotinamide riboside kinase
Sequence:
MSTAVTFFGQHVLNRVSFLRCSKEFIKKSLNHDSTVFIPFIEGEALISPENGDLVQLSNSVKSYKNILSAIVPLYTTLLNTTRSRSDESGINVTFLGLLEGTDSAFNFEWSNISYKGTPYFGLDIRVTESTLFKKVDFEPIFSYPKVTRDHIFKQTNEDASLYSQGKMYLDWLAKYKFCPGCGSPLFPVEAGTKLQCSNENRNVYCNVRDARINNVCFPRTDPTVIIALTNSDYSKCCLARSKKRYGDFVLYSTIAGFMEPSETIEEACIREIWEETGISCKNIDIVRSQPWPYPCSLMIGCLGIVQFNSKNEVINLNHDDELLDAQWFDTTEIIQALDKYAGGYRVPFKNDINLPGSTTIAFQLINHVCENYKNLRKTSSSHL
Protein: Homeobox protein ceh-37 (Q93356)
Organism: Caenorhabditis elegans
Function: Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12711598}. Chromosome, telomere {ECO:0000269|PubMed:12711598}. Note=Binds to telomeres.
Interaction partners:
- Double-strand telomeric DNA-binding proteins 2
- Double-strand telomeric DNA-binding proteins 1
Sequence:
MTSYSYFTIPSTATTGFNYPVQPMTMFSGAPYNAAMIPRKNRRERTTYSRQQLEILETLFNETQYPDVFARERVADQIRLQESRIQVWFKNRRAKYRLQEKQKPKRSNEKSQEHKSEDQQQTDVLDGEPLKGGSPGYQPQIKSELESCDGAVASGKLGTPKSISPVETTASTTSSNTSAAELQWNGDHKILGFGKNETTTSAAVSPTADNASTPSSSSSITATSSLPTTSSSLSVYNYPAIYPQWGLDYSTYANPQYAQFSHNPYAGTPFWYSNGNNL
Protein: Papilin (Q5ZR39)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHLFLLFIPHVIAVKDLAWYSANPVLSSSHPVGPAAIQAATAIDFCQLPVDTGKCSQQLVRYYYDAAVDECKRFTFSGCGGNSNRFMRRAHCRNRCVKQPNKPEVQELKHRRTVTSTTSTPFQTVNEESTVEPSATKRLPVTLPVKKLELVQSGHGNGLCQDCDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNGAVCGPNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVNLTEEDCNNGKQEIKYYYDADSVQCKQFFYGGCKTTSRNFFADLQTCDVICVSNQRDYLKSKGQSLSHHPVLEISSDLNNGNDLKSNHYKIDLFSSPSSPVTPNRPLSADDWPLKPITLKPALNLDFSQGKTKSTAEKHKEADDAEILVHQLTPEHNSCDLKFEPVLREECISADWAEKFFWNSEFKDCEPFWYDSSCDPRDRAGKNFFETFEDCKNKCDGVQSQYVVPITTVPDEQSKIEEVETSETPGIVDETTTTAAPEEESEENGFFFKVKPQNYLEDVLSSETEETQHYGFNPNEFLKQNSQNQKPTEITEILRILPAQTEHDEASELKKEDKIEHDILEHLKNKEPTEKVLSTPSTCDLEYDDALRNECTSADWTELYYWNAQFKECEAFWYDSSCGDQDFSKKNLFKNFDDCNNQCVKKIGEALKKMDPETTTTTSTTTTTTTAPTTTKMEEPKRSNYKQSDPLNLILNKALNPDESSELPEKFPPAHEQGFVNFAIKSEVTATTKFDRLKYMAEFRKKLLALPDNFSTTPKQSSPTSSPTTTRMRSPSTHKSTVSQATKTASSTPQSPSTTTSFDDFVEKEKKTVLETIKILDRPEDLCDEPLHPKLEEDCKNDQWEIQWFFNSDRGACKSFWYGGCEIESRNFFPDHANCRHSCAHKYATPASFSSKVYIPPGELSTPVPPRKDRLTTSLKLTYPHSEDLFPSEEHSTVVELDGNFQRTEKQERIRLFPTKTFRPRAPTPTASNIVNVSEGEKTETAPAFYSHIDRVVHDMKTGEHPGYTKPEEFVRRIESASNDYIKYDLQKPDVVTIIDKSPPTVPSRKERTERTEVTTKLPSTRSINDPCDDEYDPKWDEDCLGDTWVVRSYYDSKAEKCKAFWYGGCHTSSRNIWFDKETCRTSCAHKFPTDMPMYGGAQSSEVSAEILPSPQEENSSKETSSSSSSSSSSNTAHISPEHRFKVDLDQKFADVKREHEGREDLAYSQMVQHPVTVSADCLEVYNASLSKPCGDGKSWSNRYFYDKDTRSCRMFWSNGCFSSSKNNFDDLETCQWKCEGRHPQPAGKSCLDKFDERYLEDCRHGEFTNRFYFDHDRKKCVAFHWGGCQSKSQNFFADMTVCQDLCESPPRELTQACLQPFDTTYETSCSAEKPQQYYYFDMSSGICKMFWFGNCKGENQNIFSTLEACQWICERKRDERKPAICADKFDTKYTESCGDSQWTEKWYFDQSSGDCSSFWWDECTSSSQNIFPDEKSCTSNCKHPGFEISSKLATEESKFRCLEPVEIGSCQETYPAFYYDRASRTCRPFAYSGCGGNSNRFMTVSQCENLCFAFNSMNEAEVDCHLPMHIGYGKNEDSCLPQAGFRFYYDRNYGKCSQMWYLGCGGNANNFYSYEICQRTCSQSDVPRELERKTRASSEVCFEPPGDRGICGKNSSTNPLKRWTYGNQKCTSFTYSGCGGNRNRFATQDICENTCNGLMNSNDPRICSFSPDWGSCNQLRYVWFYNLTRGTCDQFLYGGCGGNPNRFDTFEICQKACEVTGTDPCMESLDRGSWCEAMSNRYYFNKRARQCKGFHYTGCGKSGNNFLTKEECQTKCEKRFPRAAPSKKKAKVKLPVGYSGAKPKDKTPMLRHINLNGNNQTYFKSEPQWMDYSSCYGYRYNVTGRDTILNVHYCAIRGSADCISESYRSTEGEEYCNILRPFLRGQNLYSFYFGLDSVNPMYRPKDGLSGRIQRKNETIAAVLVLKANQCHEIC
Protein: Protein LAZY 1 (Q2R435)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the regulation of shoot gravitropism and tiller angle through negative regulation of basipetal polar auxin transport (PAT). Acts as positive regulator of lateral auxin transport. Promotes vertical shoot growth. LAZY1 and TAC1 play opposite functions in the regulation of tiller growth angle.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17468779}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:17468779}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- Os01g0885000 protein
- Os04g0693050 protein
- Cytochrome c
- persulfide dioxygenase
- Os04g0535400 protein
- Sulfurtransferase
Sequence:
MKLLGWMHRKLRSNNDVFKEFNTGGGGACNCITGLASPDHDNDYFSGDDAAHASPPVTAGDLFTFGGSGLLTIGTLGIAAVAIPSGGDDDDYDIDFEVDATSDDDGGFTVEDDDADVGGAVTPTFTFPAATAAEAVVATVEKAVAAVEAIAEKDDDTTTEDDLMVVSAELEKVLGGVDVASARVSFAMGGGVDCPLQGFLFGSPVSDVESRPEYLQAPRDSSGSCGGGGRRTSLGELFMRTRFADEKVALVAVAEGEDGVAGDDGAAAAGVGGDRAGKGGGYKTMKKRKVKDEKGGGGAAGGGMPATVTKSKFQKILQIFHRKVYPENTLLTRNLTKKSRNRGATDNGGGAVATGDPDGPLASPVLRCRKDHPMRGFGCCTNGAFGASSPGGNAEMNGNKSGHWIKTDADYLVLEL
Protein: Outer dynein arm-docking complex subunit 3 (Coiled-coil domain-containing protein 151) (A7MBH5)
Organism: Bos taurus (Bovine)
Function: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BSN3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8BSN3}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}.
Interaction partners:
- Outer dynein arm-docking complex subunit 1
- Outer dynein arm-docking complex subunit 2
- Outer dynein arm-docking complex subunit 4
- Calaxin
- Methyl-CpG-binding domain protein 1
- Parkin coregulated gene protein
- EF-hand domain-containing family member C2
- Cilia and flagella associated protein 45.
- Tektin-3
- Tektin-1
Sequence:
MTSPLCWAAASNAMPSQDQISTPSKVKATQVQLKPYRSRGKGLVPVWHSLHSKAGPLHASEGKSAVNMQVAELQRKIQLLEGDRKAFYESTQWNIKKNQETINQLREETRVLQLQLTALLQGDEKVVQAVIREWKSEKPYLKNRTGQQALEHLDYRLNEKVKQLNALRHQLGLRQKWLEELQLQHSLRELEIAEAQDSNTEVAKTMRNLENRLEKARMKAEEAEHITSVYLQLKAYLQEESLHLGNRLDFMEAEVVRTKHELEELHLVNQEALNARDIAKNQLQYLEETVFRERKKRERYLTECKKRAEEKKLQNERMERKTQREHVLLQSDDTLQDSMYSKEEELKRRWSMYQMEVLFGKVKDATGVAETHAVVRRFLAQGDTFTQLEMLKSENEQTLLRLKQEKQRLQQELEDLKYSGEALLVSEQKRQAELQGRLKMEEQRRADAQNQLDRTMRALQITKEGLEHLAGKLNHIVVAGPTYEEGSPGASLDTKGSATPQPQETGRSVGKMDPKVDDYLPNLLGLVEEKLLKLHSQLENHNVPEMLRHIVDLEFYATLEGKLPSYNTRIALPVAGHKDKFFDEEESEEDDSDVVTRAALKMRSQKLIESRSKRRGRSRRS
Protein: GAS2-like protein 2 (Growth arrest-specific protein 2-like 2) (Q5SSG4)
Organism: Mus musculus (Mouse)
Function: Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A. Regulates ciliary orientation and performance in cells located in the airway.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23994616}. Cell membrane {ECO:0000269|PubMed:23994616}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q8NHY3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30665704}. Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (By similarity). {ECO:0000250|UniProtKB:D3ZUE1, ECO:0000250|UniProtKB:Q8NHY3}.
Interaction partners:
- Tektin-1
Sequence:
MSQHVGHGRRPRTPGPPVRSIRPFKSSEQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGVFCNGAAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGVAAPALVHLEEEIDEELRRDLALPSPDPPPPIPPARRPCHFHNLDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFLKPPGPPVQHEVKVQDGPSQPQPTMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSEPPVRARTLREDPLPRSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTLSGKRANRCPGEPPRGRTPTLWVHKEAGSRGTHTKAPTPQRLQIPEATSKRTSARGPSPPPRSSSLASPHMIWVLHQGASPQLSEPMTVHSSSPGKGLTKIPIRLSPARPPTPGRSSLGTEGEYSTGRGSISSRALEGNLDRSTHGHHSVEASGDHQTDIQTTSETEDPRSLGTQKWKERHTSLALGRRREQALYDNLKEEVVANMKLLEVGTAYTQGTRSQAIPRSGVYVPSLGGRWPEPGGPYDKVIRELVQGPPPLLKVDLKAWKVGSECLPRPIVDPGSPKEKLGSRETGTRIKASLNAEDTTVRTVSPARGQGCSTPPVSANLEAPTRSCSDPSSDKASVCLGKGKRTLRKPQKIPSIYKLKLRPRIRPRRDHRPEKRPSRIPKPLPYSCLVLARTAPGSRLLKATLGGKGGVPCQVNGTGKKEEEKKKGGSNISLESSIQPAESQEPLKLGGTPLSPEEESWV
Protein: Transcription factor bHLH30 (Basic helix-loop-helix protein 30) (AtbHLH30) (bHLH 30) (Transcription factor EN 53) (bHLH transcription factor bHLH030) (Q9S7Y1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Putative transcription factor bHLH041
- WAT1-related protein At3g45870
- Transcription factor bHLH79
Sequence:
MCAKKEEEEEEEEDSSEAMNNIQNYQNDLFFHQLISHHHHHHHDPSQSETLGASGNVGSGFTIFSQDSVSPIWSLPPPTSIQPPFDQFPPPSSSPASFYGSFFNRSRAHHQGLQFGYEGFGGATSAAHHHHEQLRILSEALGPVVQAGSGPFGLQAELGKMTAQEIMDAKALAASKSHSEAERRRRERINNHLAKLRSILPNTTKTDKASLLAEVIQHVKELKRETSVISETNLVPTESDELTVAFTEEEETGDGRFVIKASLCCEDRSDLLPDMIKTLKAMRLKTLKAEITTVGGRVKNVLFVTGEESSGEEVEEEYCIGTIEEALKAVMEKSNVEESSSSGNAKRQRMSSHNTITIVEQQQQYNQR
Protein: Uncharacterized protein (A0Q7H3)
Organism: Francisella tularensis subsp. novicida (strain U112)
Interaction partners:
Sequence:
MSKADHIFNLEEQGLLIDIKDDSKGCTTKLESSGKITHNATESIESSADKQIIENVKDSKISITEKEILLATKKSSIMLSEDKIVIKIGNSLIILDDSNISLESATINIKSSANINIQASQNIDIKSLNNSIKADVNLNAEGLDVNIKGSVTASIKGSAATMVG