wanglab/gogpt-training-data huggingface dataset:
Protein: Decaprenyl-diphosphate synthase subunit 2 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 2) (Decaprenyl pyrophosphate synthase subunit 2) (O13851)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24911838}.
Interaction partners:
- Atypical kinase COQ8, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Decaprenyl-diphosphate synthase subunit 1
- Ubiquinone biosynthesis protein coq11
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Ubiquinone biosynthesis protein coq9
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Squalene synthase
- Ubiquinone biosynthesis protein coq4, mitochondrial
Sequence:
MSFPFASLLKRPSAISSLLSLKKPGSWSSILLKAVGVLSRDSRWHSDLLKMLTEEMDSLNGQINTWTDNNPLLDEITKPYRKSSTRFFHPLLVLLMSRASVNGDPPSQQLFQRYKQLARVTELIHAANIIHINIGEEQSNEQIKLATLVGDYLLGKASVDLAHLENNAITEIMASVIANLVEGHFGSRQNGSVGLSNERTILLQSAFMPAKACLCASILNNSSQYINDACFNYGKFLGLSLQLAHKPVSPDAQVLQKNNDILKTYVENAKSSLSVFPDIEAKQALMEIANSVSK
Protein: Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) (P10275)
Organism: Homo sapiens (Human)
Function: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Subcellular location: Nucleus {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:15634333, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19244107, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:25091737}. Cytoplasm {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19244107}. Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:25091737}.
Interaction partners:
- Nuclear receptor coactivator 2
- Nuclear receptor coactivator 4
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- E3 ubiquitin-protein ligase Mdm2
- Nuclear receptor coactivator 3
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- Hepatocyte nuclear factor 3-alpha
- Catenin beta-1
- Prostate-specific antigen
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
Protein: Lipoprotein lipase (LPL) (EC 3.1.1.34) (Q9W6Y2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362020}; Peripheral membrane protein {ECO:0000256|RuleBase:RU362020}; Extracellular side {ECO:0000256|RuleBase:RU362020}. Secreted {ECO:0000256|RuleBase:RU362020}. Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU362020}. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells. Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles. {ECO:0000256|RuleBase:RU362020}.
Interaction partners:
Sequence:
MGKENTFLVTVWIILANICVSFSSTPEQTLFGNSNSTEWLEDYTDIVSKFSLRTAEIPDDDLCYIVPGQPSTIPKCEFNPGYKTFVVIHGWTVTGLFESWVPKLVTALYKREPKANVIVVDWLTRAQQHYLTSAANTKLVGKDVAKFVNWLQKTLDYPWEKIHLLGYSLGAHVAGIAGLLTNHKVSRITGLDPAGPTFEFADAQSTLSPDDALFVDVLHTNTRGSPDRSIGIQRPVGHVDIYPNGGTFQPGCDLQNTMMMIATTGIRNMDQLVKCSHERSIHLFIDSLVNAAEHQTMAYRCSSKEAFMKGMCLNCRKNRCNKVGYGVNKVRLPRNTKMYLKTREMMPFKLFHYQVKVHFFSSEKLAYTEQPMKISLYGTHDEKIDIPYTMPFLNTNSTVSFLLTTDVDVGELLMVKLRWEKDAYFSWSDIWGNKNFHIRKMRVKAGETQSRVIFSAKDGEYAYLIRGKDDVVFVKSKEDNMSRKEKTMHRLKMQGSHFKNNIA
Protein: Packaging protein 1 (Packaging protein IVa2) (P03272)
Organism: Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Function: Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04057, ECO:0000269|PubMed:18614642}. Host nucleus, host nucleoplasm {ECO:0000255|HAMAP-Rule:MF_04057, ECO:0000269|PubMed:8627656}. Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04057, ECO:0000269|PubMed:8627656}. Note=Located at a unique vertex of the capsid. Present in about 6-8 copies per virion. {ECO:0000255|HAMAP-Rule:MF_04057, ECO:0000269|PubMed:18614642}.
Interaction partners:
Sequence:
METRGRRPAALQHQQDQPQAHPGQRAARSAPLHRDPDYADEDPAPVERHDPGPSGRAPTTAVQRKPPQPAKRGDMLDRDAVEHVTELWDRLELLGQTLKSMPTADGLKPLKNFASLQELLSLGGERLLAHLVRENMQVRDMLNEVAPLLRDDGSCSSLNYQLQPVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQICEGNYAPGPDGTIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAISLLLKDIFRHHAQRSCYDWIIYNTTPQHEALQWCYLHPRDGLMPMYLNIQSHLYHVLEKIHRTLNDRDRWSRAYRARKTPK
Protein: Mediator of RNA polymerase II transcription subunit 21 (CeSRB7) (Mediator complex subunit 21) (Q6BER6)
Organism: Caenorhabditis elegans
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 7
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 10
Sequence:
MADRMTQLQDMINEMAGLMTNAIGVLQATAPPCEFGAISQELEDEPNCAIFAAGIAKAAKNIEILIDSFPIEAGNQEAEVEEKMIKNDEKQREKVNELVGLVGDSNRLVGVVQKKLAEISKTQMSSRPSE
Protein: Gibberellin 20 oxidase 3 (OsGA20ox3) (EC 1.14.11.-) (GA 20-oxidase 3) (Gibberellin C-20 oxidase 3) (Q69LD8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Key oxidase enzyme in the biosynthesis of gibberellin. Catalyzes the formation of bioactive gibberellins (GAs) via a three-step oxidation at C-20 of the GA skeleton. Controls the elongation of the vegetative shoot and plant height by the regulation of active gibberellin levels.
Interaction partners:
- Ent-kaurenoic acid oxidase
- Gibberellin 2-beta-dioxygenase 5
- Gibberellin 2-beta-dioxygenase 6
- Gibberellin 2-beta-dioxygenase 3
- Os02g0630300 protein
- Gibberellin 20 oxidase 1
- Os05g0514600 protein
- Gibberellin 2-beta-dioxygenase 1
- Gibberellin 3-beta-dioxygenase 1
- Gibberellin 3-beta-dioxygenase 2
Sequence:
MAAVVFDAAILSKQEAIPAQFVWPADEAPAADDGVVEEIAIPVVDLAAFLASGGIGRDVAEACERHGFFQVVNHGVDPALLAEAYRCCDAFYARPLAEKQRARRRPGENHGYASSFTGRFDCKLPWKETMSFNCSAAPGNARMVADYFVDALGEEYRHMGEVYQEYCDVMTRLALDVTEVLAVALGLGRGELRGFFADGDPVMRLNHYPPCRQPHLTLGTGPHRDPTSLTLLHQDDVGGLQVLPDDAAAAAGGWRAVRPRADAFVVNIGDTFAALTNGRHASCLHRAVVNGRVARRSLTFFLNPRLDRVVSPPPALVDAAHPRAFPDFTWREFLEFTQRHYRSDTNTMDAFVAWIKQRNGYESLDKY
Protein: 3-methylmercaptopropionyl-CoA ligase (MMPA-CoA ligase) (EC 6.2.1.44) (Acyl-CoA ligase) (Q5LRT0)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Function: Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton. Catalyzes the ATP-dependent ligation of methylmercaptopropionate (MMPA) and CoA to yield methylmercaptopropionate-CoA (MMPA-CoA). It is also active with short-chain-fatty-acid (carboxylic acids up to six carbons in length).
Interaction partners:
- 3-methylmercaptopropionyl-CoA dehydrogenase
- Dimethylsulfoniopropionate demethylase DmdA
- Methylthioacryloyl-CoA hydratase
Sequence:
MLGQMMYQPLLISSLIDHAARYHGEAQIWSVSTEGGVEETNWAGIADNARRLGSVLTDAGLAPQSRVATLAWNNRRHLEIYYGVSGAGFVLHTINPRLFPEQLVYILNHAEDRILFFDATFLPLVEGIRPHLTTVERLVLMGPRDEAAAARIEGLEFYDEFVATGDAGFDWPDLDERTASSLCYTSGTTGNPKGVLYSHRSTVLHSFGSNTRDCIGFSARDVVMPVVPMFHVNAWGTPYACAMSGSCMVLPGPDLHGEALVGLIDRYRVTIALGVPTIWQGLLATARAKGSTLESLTRTVIGGAACPPSMIAEFRDRYGVDTVHAWGMSEMSPLGTTNQPLAKHGALPIEAQHKLRENQGRPPYGVELKIVDDDGNTLPNDGQTQGDLMVRGHWVLDSYFQLQDQPILSDGWFATGDVATLDRDGYMTIRDRSKDIIKSGGEWISSVELENIAVAHPKLATAAVIGVPHPKWDERPLLVAVKAEGETPDEAELLAFFDGKIAKWQVPDRVVFVEALPLNATGKVLKRTLREQFRDVLTG
Protein: SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) (P16333)
Organism: Homo sapiens (Human)
Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Subcellular location: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
Interaction partners:
- Lymphocyte cytosolic protein 2
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
- WAS/WASL-interacting protein family member 1
- Serine/threonine-protein kinase PAK 1
- Proto-oncogene vav
- Nephrin
- NCK-interacting protein with SH3 domain
- Growth factor receptor-bound protein 2
- TRAF2 and NCK-interacting protein kinase
Sequence:
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
Protein: Protein kinase C (EC 2.7.11.13) (A0A1D5PCZ1)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAEPPAAPGPEGEEGPVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIRADIEKDVLTVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIKCSLNPEWNETFRFQLKEADKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKSGVDGWFKLLSQEEGEYFNVPVPPEGEEGNEELRQKFERAKIGTGSKAADEKTTNAISKFDNNGSRDRMKLSDFNFLMVLGKGSFGKVMLAERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALSGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYQIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPAKRLGCGPEGERDIKEHAFFRYIDWDKLERKEIQPPFKPKAKDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVINV
Protein: Neuritin (Q9NPD7)
Organism: Homo sapiens (Human)
Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Synapse {ECO:0000250}.
Interaction partners:
- Neurotrophic factor BDNF precursor form
- Neurotrophin-3
Sequence:
MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPAFPVLLVSLSAALATWLSF
Protein: Ribosome assembly 1 protein (Q08932)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in a late nucleoplasmic step of 60S ribosomal subunit assembly.
Subcellular location: Nucleus.
Interaction partners:
- 13 kDa ribonucleoprotein-associated protein
- Protein HIT1
- Nucleolar protein 58
- Protein interacting with Hsp90 1
- Nucleolar protein 56
- RuvB-like protein 2
- RuvB-like protein 1
Sequence:
MNYNNFENSKGDGHSRLPKPTYSGTLSDGYDESKIKRQKTDSAFNAAYSPHMYPNSPYYEGSWNTGYTPQLHHVAPHNQYFHPIQPSTQYNYTSPPNYTENYIPPVHQNISYAPALNLQKWPSSYCENTQALKNDKDYQTSISYEDVAIPTVKEIQLIEKNRGKDTFMNEISPVPSSKDQASAEPTEIPRKDPELANSNAEDDHNNLGLEDDDRDEQLESEGLGKVVLVPGTSIALITDEDVKKWREERKKMWLLKISNNKQKHMQEMGIKEDELKSQPSIFKESRKEKQFIQSIQNQVQRGNPKIDLNLKLIQREFANENSQLLDFIRELGDVGLLEYELSQQEKDVLFGSSEDNNKNHYKPNYKNRKPNLSRANFTRNK
Protein: AT11343p (Q8T481)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
- ATPase ASNA1 homolog
- DSec61alpha
Sequence:
MTLFALIALLSLLNTILPDFIRNYLKVSRLWGVRNSAEIRQLQTELDDARKQVEVVSNAEHSGEYARTIKIMRAERKVSEAEAKLKSARGMENFMRISIDTAMFYGSKVLLSAITVFISIRNRGTPVMIIDEAISLAPFTGLLSFPTGVANAISVPAWAFSCNLTFRLIYGFVKNRGA
Protein: Zinc finger protein 765 (Q7L2R6)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNREVFHAGTSQRHESHHNGDFCFQDIDKDIHDIEFQWQEDERNGHEALMTKIKKLTGSTERYDQNYAGNKPVKYQLGFSFHSHLPELHIFHTEEKIDNQVVKSIHDASLVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQEVHMREKSFQCNDSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECGKTFSQTYYLTCHRRLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQKSYLTCHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRRLHTEEKPYKCNECGKTFNQQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSNLERHRRIYTGEKLHV
Protein: Alpha-glucosidase MAL32 (EC 3.2.1.20) (Maltase) (P38158)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Invertase 2
- Maltose permease MAL31
- General alpha-glucoside permease
- Maltose fermentation regulatory protein MAL33
- Glucoamylase, intracellular sporulation-specific
- Maltose fermentation regulatory protein MAL13
- Alpha-glucosidase MAL12
- Hexokinase-1
- Hexokinase-2
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
Protein: Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)] (Q8WWG1)
Organism: Homo sapiens (Human)
Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Subcellular location: [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted {ECO:0000250}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Pro-neuregulin-2, membrane-bound isoform
- Pro-neuregulin-3, membrane-bound isoform
- Pro-neuregulin-1, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-3
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
- Pro-epidermal growth factor
- Probetacellulin
- Proepiregulin
Sequence:
MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH
Protein: Importin subunit beta-2 (Importin-104) (Karyopherin subunit beta-2) (Karyopherin-104) (Transportin) (TRN) (O14089)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus envelope {ECO:0000269|PubMed:15116432, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable importin subunit beta-4
- Exportin-1
- Importin subunit alpha-2
- GTP-binding nuclear protein spi1
- Nuclear polyadenylated RNA-binding protein nab2
- Importin subunit beta-5
- Uncharacterized protein C11G11.07
- Exportin-T
- Nucleoporin nup189
- Importin-alpha re-exporter
Sequence:
MGDNPWVLQEQVLVELSEVIKNSLSENSQTRNAALNLLEKAKDIPDLNNYLTCILINATELSVSIRSAAGLLLKNNVRVSSLESGSGLQSLDYTKSTVIRGLCDPEQLIRGISGNVITTIISRWGISTWPEVLPQLMEMLSSPASTTQEGAFSALTKICEDSAQELDRDFNGTRPLDFMIPRFIELARHENPKIRTDALFCLNQFVLIQSQSLYAHIDTFLETCYALATDVSPNVRKNVCQALVYLLDVRPDKIAPSLGSIVEYMLYSTQDSDQNVALEACEFWLAIAEQPDLCSALGPYLDKIVPMLLQGMVYSDMDLLLLGNDADDYDVEDREEDIRPQHAKGKSRITLNTQGPITQQGSSNADADELEDEDEDDDEFDEDDDAFMDWNLRKCSAAALDVLSSFWKQRLLEIILPHLKQSLTSEDWKVQEAGVLAVGAIAEGCMDGMVQYLPELYPYFLSLLDSKKPLVRTITCWTLGRYSKWASCLESEEDRQKYFVPLLQGLLRMVVDNNKKVQEAGCSAFAILEEQAGPSLVPYLEPILTNLAFAFQKYQRKNVLILYDAVQTLADYVGSALNDKRYIELLITPLLQKWSMIPDDDPNLFPLFECLSSVAVALRDGFAPFAAETYARTFRILRNTLYLITTAQNDPTVDVPDRDFLVTTLDLVSGIIQALGSQVSPLLAQADPPLGQIIGICAKDEVPEVRQSAYALLGDMCMYCFDQIRPYCDALLVDMLPQMQLPLLHVSASNNAIWSAGEMALQLGKDMQQWVKPLLERLICILKSKKSNTTVLENVAITIGRLGVYNPELVAPHLELFYQPWFEIIKTVGENEEKDSAFRGFCNILACNPQALSYLLPMFVLCVAEYENPSAELRDMFQKILQGSVELFNGKASWQASPEVLAQIQAQYGV
Protein: Olfactory receptor 8A1 (Odorant receptor M71) (Olfactory receptor 151) (Olfactory receptor 171-2) (Olfactory receptor 7H) (Q60893)
Organism: Mus musculus (Mouse)
Function: Odorant receptor.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MTAENQSTVTEFILGGLTNRPELQLPLFLLFLGIYVVTMVGNLGMITLIGLNSQLHTPMYFFLSNLSLVDLCYSSVITPKMLINFVSQRNLISYVGCMSQLYFFLVFVIAECYMLTVMAYDRYVAICQPLLYNIIMSPALCSLLVAFVYAVGLIGSAIETGLMLKLNYCEDLISHYFCDILPLMKLSCSSTYDVEMAVFFLAGFDIIVTSLTVLISYAFILSSILRISSNEGRSKAFSTCSSHFAAVGLFYGSTAFMYLKPSTASSLAQENVASVFYTTVIPMFNPLIYSLRNKEVKTALDKTLRRKVF
Protein: Ankyrin and IPT/TIG repeat-containing protein C26H5.05 (O13987)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable acyl-CoA desaturase
- Cell division cycle protein 48
- Ubiquitin fusion degradation protein 1
- Putative ubiquitin thioesterase otu1
- Ubiquitin homeostasis protein lub1
Sequence:
MNLEFSFGNLIAKNTENSTKEEGTWEVNKLMKFSSEEGRSSSDDYMFSSPDFEKAGNGDAEMREFFNFDGLPDQGLNLPSIAPPSLSHASSPNLSNSQDEAECLPSDRQQDYINPSLHLNRTVFPTPQHSISDANFLANTVDQPLGDNPMFGESDVYLLKMDPMKQAPYEAGFNSVKSSGAIEDPLQFRQPITMLETPFNESINTLTPYAEDYAFSSLNTSAPPLSNKEYAFSVNHLPAINEHKWKSRVETNMLFELRIKSNDNQSVPFEYLRLPSWAHREDKKRSSKPQPLQPDPETVIHLVPTVLAGDKSSVVKTCCTRCLLRERKRNARSQATKDACMPNYTKLKAYERNMTDASPEEKQQFRIKLLNQFPKLEDIDEDRMIMVFTGPEYVRLQLDGNERVAHINARITCYSSHQSCPYFHIIWDLYSMSRLVDRLVFPEPVTVLDDHKSRNLTKSEKTGKSNSQQAPSNHVLSKSNTVPNLVTGFPTRSDNPPNEKRRRTSSSENSRALDIQLSASDSHSPNSKSTLKSVEGSAFSMSKSPSVLSMTTPSGVSPSISKNGFHVVRVPSDAAGFQQRQQQEEGVLEAHTNESAPIAPFPYCTDDFSFSVEEKSSVNNLLTQFDEVAKPDFVSTPIKENVDSSFINMTPPDVSHAPLISRIIPNKGSIMGGYEVTILGANFFNGLVCLFGDNPAAVTFSWSESTIIATCPPATNAGTVPVTFQNYNSSSEAPVMFTYEDNLDNELYKLTVQVLGLKLTGSIQNPLTLSKKLLSSWRDDFAQYITNSIKQPPNSESKGQSKKTLLHDSNMESLKSVISRIVKKDSNQSDDSVESTILAAFALVTDTTTPYLSDFSLVNESGRSLLHLTAACGLSNASTFLCNAGCDVNKRDALGYTPLHYASLYDHKDICVNLLSNGAKPDVIGASGKKPIDLSSSEPIKLVFKEANNEQAQSISRSLIKDSEGSINTNETLESTSIVNEIEESAVQTKSYSESMWNKTVTMFPSLQELPQNYMSEVPSMMQKAMLSTLKSISAIPDDVPPPYSEFADDTTAQAGSSKRDSAISEDPDHHKSVWWSLRWQSRLVGRGKSTALTPEETRAIQEQAKTLKKAGMDFMLFSFWLPALLLLSIFGLRSYAQMIGGYLYRCIIGI