wanglab/gogpt-training-data huggingface dataset:
Protein: Probable WRKY transcription factor 35 (WRKY DNA-binding protein 35) (O64747)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- B3 domain-containing protein At5g25475
- B3 domain-containing protein REM2
Sequence:
MDNFQGDLTDVVRGIGSGHVSPSPGPPEGPSPSSMSPPPTSDLHVEFPSAATSASCLANPFGDPFVSMKDPLIHLPASYISGAGDNKSNKSFAIFPKIFEDDHIKSQCSVFPRIKISQSNNIHDASTCNSPAITVSSAAVAASPWGMINVNTTNSPRNCLLVDNNNNTSSCSQVQISSSPRNLGIKRRKSQAKKVVCIPAPAAMNSRSSGEVVPSDLWAWRKYGQKPIKGSPYPRGYYRCSSSKGCSARKQVERSRTDPNMLVITYTSEHNHPWPTQRNALAGSTRSSSSSSLNPSSKSSTAAATTSPSSRVFQNNSSKDEPNNSNLPSSSTHPPFDAAAIKEENVEERQEKMEFDYNDVENTYRPELLQEFQHQPEDFFADLDELEGDSLTMLLSHSSGGGNMENKTTIPDVFSDFFDDDESSRSL
Protein: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 (Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) (F1R6J2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Engulfment and cell motility 2.
- Rac family small GTPase 1a
- Rac family small GTPase 2.
- Rho-related GTP-binding protein RhoG
- Cell division control protein 42 homolog
- Cell division cycle 42-like 2
Sequence:
MSEINTEEDNQHENECLSGKDSDRQLRLRLCVLNEILNTERDYVRNLTFLQSAFLQRIRQTAENQQCLTQEQVKVLFSNIESILDVHREFLSTLDASLQPEPQAHHSLGHVFLQFKVRFSVYGEYCSNHEKALRLLMELNKIPHIRAFLLHLMLLGGKKSTDVPLEGYLLSPIQRICKYPLLLRELLKRTPKKHSDYPAVEEALQAMKAVCCNINETKRQMEKLEALEILQSHIEGWEGTNLTDICTELLLQGNLLKISAGNIQERVFFLFDNLLVYCKRKSRVSGKKSTKRTKSINGPQYVFRGRINTEVMEVENVEDGTADYHSNNYTVTNGWKIHNTAKNKWFVCMAKNAEDKQKWLDAILKEREQRESLKLGMERDAYVMIAEKGEKLYHMMMTKNRHLIKDRRRKLTNVPKCFLGNEFVSWLLESGEISKAEEGINLGQALLENGIIHHVSDKHQFKNEQVLYRFRYDDGTYKARSEMEDIISKGVRLYCRLHSLFTPVVKDRDHHLKTFKSVIPASKLVEWLVSQGDSASREDAVTLGVGLCNAGFMHHVLEKSEFKDESQFFRFYADEETEGTSSKSKQLRSDFKLIENILAKSLVIHPEEEDYGFEIEEKNKAIIVKSVSRGSYAEMAGLQPGRKIYSINEDLVFLRPFSEVETMINQSFCIRRSLRLLVATKNKEIVKIPDVHGTLPFVLSGSCPPHIHAVKKGSEAAAAGLQPGQCVLKVNGNNMNQSGYQEVLEHFSGYQPVLEQQDTSCGQWAYRVYEDVEEQMSFRGCENGSDSEDGCTNGTGSVRRLEQLSISDDGPLVSLNVDNVHVEHGVVYEYVSPAGIKHCVLEKMVEPKGCFNLTAKILKAFVKDDSLFVKSCRQLMALNDKVVTMPQFEFRNICDTKLESIDKRISSYKQFVEELQTKAWPTFKQASTKPHILGCMDFVPTNCHLNLMQVSCPKNTSSAGRAFSIRFGRKNSFFGLDPDQANLNPMSHSVHCVTSMGAPSFSCQSLDEETENGEGNSEDSRKHEEGGLSFLLKQEDTESQDNYICLYNRLDIAVREMKQYVAQIDVLLSSITGPTQPQGSEPPSFESGPSTSPIPEETDQDKTEHCGNKRVCFKVNEDDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMQIPFDKQDKLHGCLEHLFNQVDSINSLLKGPVMSKACEETKHFHTDHSQPEFRHTDDWTVRWRYVLHKNIQEDPWNLPISIKSLINSLHRFVEDGRSQLLLALLKCTDTKLQLRRDVIFCQSLVGALCALAEQLVTALNLRFNNNGEYEEDSKEVSHKWLEQISTIGVLFNFQSTLSPHVREERIMLEDTKAALQDLEKVTVLFRPLENECLVPNTSVHYQVEGSRQAIRVTMFLDNCHFSELPTRLQNGGSLKLQSVLFTRGLEKPEGVLSQDFVTMEEFQQRTNALSLEKVKGYYRKLRAFYLEKSNSDSNSTAMKIDQLLRPLNTLDDLCRLMQTYMNVKASSAGQPSGVSVLLVSSELCNRLGACQITMCATGMQRCTLTVSLEQATILARNHSLMPRCLMQTMDLMRKQGTRVEISAKNLRVMDQMPPLAPRLFRLCLPPSDGDL
Protein: Zinc finger protein-like 1 (E9PQ47)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000256|ARBA:ARBA00004612, ECO:0000256|RuleBase:RU369078}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004612, ECO:0000256|RuleBase:RU369078}.
Interaction partners:
Sequence:
MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNIPLASRETTRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNGPIFPPTNLAGPVASALREKLATVNWARAGLGLPLIDEVVSPEPEPLNTSDFSDWSSFNASSTPGPEEVDSASAAPAFYSQAPRPPA
Protein: Trailer hitch, isoform D (M9PFF9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYILFRGSDIKDIRVVNNHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVPSQQPPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFGNLGGPNLANMVGNAGGSLAPGSGAPGSGPFMHIGGNQQQPKPQQQKQPISVLDMLAGASRSTTPISLIVSPTAELTQQQQLHQQQNAGQGGNGRDAGHKRQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSGRQMDNNYSNNYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMMNMRNRGMGSRGPMRPNQGYRPQSANNQNKPRNKIKFEGDFDFEQANNKFEELRSQLAKLKVAEDGAPKPATNATAATATATNEQLNGETDKKDDSGNETGAGEHEPEEDDVAVCYDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSSTRRGSYRGRNQYYNNNGNGGINSGYGGAPGYNRNNYRMGGGGGNFRNRSNNRNNGGGRGGNGMPNITNGNTAAALKAANNAAGHGSNATDSSAPNATTATTKSTSLLPEQTQQVAAVSQ
Protein: Origin recognition complex subunit 4 (Q9W102)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007858}.
Interaction partners:
- Origin recognition complex subunit 5
- Origin recognition complex subunit 3
- Origin recognition complex subunit 1
- Cell division control protein
- Double parked, isoform A
- Origin recognition complex subunit 6
- Origin recognition complex subunit 2
- DNA replication licensing factor Mcm2
- DNA replication licensing factor Mcm6
- DNA replication licensing factor Mcm3
Sequence:
MPEADRELVSIRRFLKERLQRDYTTLRGYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVLADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQLENAADGKVFGSFAENLAFLLQCLKAGGKHSKSVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRVKSRFSHRQVFLFPSLRRFEDYVDLCRDLLSLPTGNSLLLAAEKIYNLQNIQSGALYFSRNHFDPGEYGFSPRLRDAWNKQICKVLATQQARSTLQALHDFDISEAYLKNFLFRLVAHLRPQSPHITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDSFNFEIIYARFSKFAKVSTTMQAVERSIVLKAFEHLRIAELIMPLTGGAGGGVGKVQKEFEMHKLALTYSQIHHCMQRYQALPTEVAQWAQSSLI
Protein: Ecdysone-induced protein 75B, isoform A (E75-B) (Nuclear receptor subfamily 1 group D member 3, isoform A) (P17672)
Organism: Drosophila melanogaster (Fruit fly)
Function: Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
Sequence:
MVCAMQEVAAVQHQQQQQQLQLPQQQQQQQQTTQQQHATTIVLLTGNGGGNLHIVATPQQHQPMHQLHHQHQHQHQHQQQAKSQQLKQQHSALVKLLESAPIKQQQQTPKQIVYLQQQQQQPQRKRLKNEAAIVQQQQQTPATLVKTTTTSNSNSNNTQTTNSISQQQQQHQIVLQHQQPAAAATPKPCADLSAKNDSESGIDEDSPNSDEDCPNANPAGTSLEDSSYEQYQCPWKKIRYARELKQRELEQQQTTGGSNAQQQVEAKPAAIPTSNIKQLHCDSPFSAQTHKEIANLLRQQSQQQQVVATQQQQQQQQQHQHQQQRRDSSDSNCSLMSNSSNSSAGNCCTCNAGDDQQLEEMDEAHDSGCDDELCEQHHQRLDSSQLNYLCQKFDEKLDTALSNSSANTGRNTPAVTANEDADGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQHPQLHHHLTAGAARYRKLDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRALRHREFETAEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAAAGNPAQSQLHMHLTRSSPKASMASSHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVGSPNPGLSAAVHKVMLEA
Protein: Importin subunit alpha-1 (Karyopherin subunit alpha-1) (Q22560)
Organism: Caenorhabditis elegans
Function: Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11311162}.
Interaction partners:
- Importin N-terminal domain-containing protein
- Importin N-terminal domain-containing protein
- Nsp1_C domain-containing protein
- Importin N-terminal domain-containing protein
- Exportin-2
- Nucleoporin p58/p45
- Nuclear cap-binding protein subunit 1
- RanBP2-type domain-containing protein
- Exosome complex component 10 homolog
- Nuclear Pore complex Protein
Sequence:
MGDEFRPSHEERSKMYKSNVRDQNEMRRKRREDEVQIRKNRRDEKFERNRQITVQRSLSHEETSELLKSVADGLQSMQETTIHEALTVLHENLNNTVWTIHVLVKVQILHKLSDVYCNRVISQTTRLLISRTLLKISGIDEVKYERYSSDDRCIQSLVFNISTYGSSEDILCDTFQSIACFIIRSITYRNLALDCAIVSELIDASTINMSIILHRSLMWLVFLFCEKLDRCSPHVDEIAPLLEIISNGIQSTDAMVQTDAASSCASLAEWPPIYHYMSDLKLCSKLVANLRNDKGNARPKVKAGINSIIQATGYFTEEMIDAGLLEVLKGFVNVSYMSQEVCFIISNICVEGEQTIDKLISSGVLREVARVMEASEYRSRREAAFVICHCCASANQKHLEYVVELGMLSAFTDLLTCMDVSLVSYILDAIYLLLQFGEMRLLPDNSNPVAIKLEEIGCREKLEFLCESQSVDIHARAYTIIDRFYVDDDAPLNDDPFAGYQRNNIDDTIEKMIREPIMDQPFSF
Protein: Probable glutathione reductase 2 (GR) (GRase) (EC 1.8.1.7) (P30635)
Organism: Caenorhabditis elegans
Function: Maintains high levels of reduced glutathione in the cytosol.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable thioredoxin-2
- Probable selenide, water dikinase
- Thioredoxin
- Kynurenine--oxoglutarate transaminase
- Kynurenine--oxoglutarate transaminase
- Putative cystathionine gamma-lyase 2
- cystathionine gamma-lyase
- Selenocysteine lyase
- Thioredoxin domain-containing protein
- Thioredoxin reductase 1
Sequence:
MLLSTFKRHLPIRRLFSSNKFDLIVIGAGSGGLSCSKRAADLGANVALIDAVEPTPHGHSWGIGGTCANVGCIPKKLMHQAAIVGKELKHADKYGWNGIDQEKIKHDWNVLSKNVNDRVKANNWIYRVQLNQKKINYFNAYAEFVDKDKIVITGTDKNKTKNFLSAPNVVISTGLRPKYPNIPGAELGITSDDLFTLASVPGKTLIVGGGYVALECAGFLSAFNQNVEVLVRSIPLKGFDRDCVHFVMEHLKTTGVKVKEHVEVERVEAVGSKKKVTFTGNGGVEEYDTVIWAAGRVPNLKSLNLDNAGVRTDKRSGKILADEFDRASCNGVYAVGDIVQDRQELTPLAIQSGKLLADRLFSNSKQIVRFDGVATTVFTPLELSTVGLTEEEAIQKHGEDSIEVFHSHFTPFEYVVPQNKDSGFCYVKAVCTRDESQKILGLHFVGPNAAEVIQGYAVAFRVGISMSDLQNTIAIHPCSSEEFVKLHITKRSGQDPRTQGCCG
Protein: Motilin-like (E9QFU1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Motilin receptor
- Peptide YYb
- Relaxin family locus A type 1.
- Membrane-bound ghrelin O-acyltransferase mboat4
- Appetite-regulating hormone isoform X1
- Proenkephalin a
- Galanin peptides
Sequence:
MRGSVTGCVLLICVVALLAEQAEGHIAFFSPKEMRELREKEGRKDADSRAEGLLVDETSPEEDGGESAGQPVEIGLKLTAKKSHIGSAFGKMLQNIVEEPDNAN
Protein: Nidogen (C7FZU4)
Organism: Caenorhabditis elegans
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
Sequence:
MKHKKMLILLFLYLLIETTTANPAFYPYGQPAGDNRLDYSMEQSAIALKIPLTYMEQSVDELFLSHNGIVGLGKPTPEKIGGLMTISTPAIAVFYVPVTSGVIDYRVSSDDQGLLTKLTQDVKQVFADAVEFHGLQAVIITWTQIENAEKDGPASFQLAIVSDGISTYAIFRYESLPWSSSMGYYAQAGFVRSIGKIQTNVNSGGPDVKELVNLSNNQFGNFFIFRVSGSAIEDPKDEGADDYDYNNYDQEYEGEHPADCPKDKFVDNCPAECRTVRDERGCERCICAERPHAPRAPQEPRPELENTVEDDEDDEQVDGTRYEEPARQAQEQHHQQHHQPDQPQQQPQRSQEGSLPKMSCSQRDDKSCHANSVCQDFEGGFCCNCDTGFYGNGKECLPKGEPQRISGSFEGVINRIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFADVQSPNVYNGFQLTGGLFNRTVALHIEQNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIVRDGGNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNFATRSVGPAVSAPSGGHFDRRQHGQSNMASERPIEIPSQSESISTDSVCAPGRHQCTLPNMKCRVVDPSYRCECEPGYQAAHDASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGSFSCQCLQGYQGDGRSCIREHQASHHEHNQQTPQEMAGVGATTEGFCTAHNQCHQWGECVFTSEHPTGRCKCRGWYVGDGVNHCGPPEENMPKHNANIPQRGGQACGSYVCDVNAECMPEPSGGSECVCKAGFSGNGVTCESLLDDRHAHSSHNRHEQQQQTGSLGKVCRSHDECSEHGSCAYHHSLGYYQCACTEPYVGNGVECTLPGSSASAESSTRSDKLLVARGMAIFERSTNPDEYGKQLIVIPHHIPVGIDFDCKEEKIVWSDMSGHSIRTSSLNGTEHKSYFNKELSSPEGIAVDWSSRNVYYADSMNDEIGVASLNGKFKKSLVTEGLVNPRSVVLDLYGRHLYYSDWHRENPYIGRVDMDGKNNRVFLNEDVHLPNGLTILPNRRELCWVDAGNHRLSCIQYNGAGRRTVFSSLQYPFGLTHDEEQKFYWTDWKDNRIHSVGVYGEGYRSFQISLGGSGKVFGILAVPKSCVGPSTPCSEDNGGCQHLCLPGQNGAVCECPDNVKVKGC
Protein: Kinesin-like protein (F1R5M2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Glutamate receptor-interacting protein 2a
- Bucky ball
- Syntabulin
- Kinesin light chain
- Kinesin light chain
- Kinesin light chain 4
Sequence:
MADPAECTIKVMCRFRPLNSSEVTRGDKYIPNFQGQDSVVIGGKPYVFDRVFQSNTTQEQVYTACAQQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGNLHDTDGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPEEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSSLGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSAFNEAETKSTLMFGQRAKTIKNTVCVNVELTAEQWKKKYEKERERNKSLRNTITWLENELNRWRNGETVPAEEQYDKEKVNAEVLALDNTINNDKFASTPSMPPMPGMLGTRLTGVEKDKCEVELGKLYKQLDDKDEEINQQSQLVEKLKQQMLDQEELLASSRRDHDNLQAELTRLQLENEASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEFEALSEELSQKSSTLASIDSELQKLKEMANHQKKRVTEMMSSLLKDLTEIGIAVGNNDIKHEGSGLIDEEFTVARLYISKMKSEVKSMVKRCKQLENTQSESNKKMDESDKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEEDVDSLNEELVKISAQEKVHAMEKESEIQSANEVKEAVEKQIQSHREAHQKQISSLRDELETKEKLITDLQDQNQKIMLEQERLRVEHEKLKSTDQEKSRKLHELTMMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEMDSDETGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALETALKEAKENAARDRKRYQQEVDRIKEAVRAKNMARRGHSAQIAKPIRPGQQPVASPTHPNVLRGGGGVLYQNSQPMPIRGGGTKQEKS
Protein: At2g17975 (Predicted protein) (Zinc finger (Ran-binding) family protein) (Q8S8K1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Selenoprotein O
- Afadin/alpha-actinin-binding protein
- Pentatricopeptide repeat-containing protein At4g35850
- Omega-amidase, chloroplastic
- Protein PEP-RELATED DEVELOPMENT ARRESTED 1, chloroplastic
- Probable LRR receptor-like serine/threonine-protein kinase RFK1
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- RNA-binding protein 1
Sequence:
MGDGREGDWECLGCRNRNYAFRSFCNRCKQPRLIMDNNTSPNSKWLPRIGDWICTGCTNNNYASREKCKKCGQSKEVAALSALAIPGASLQTHLHYFTRGPESHDQPGSLLAFSNATNQASVHKEWRSGDWICRCGFHNYSSRIQCKKCNEIAPLALGTKRLASEALAHEWDSKRLNQGYTSMQTQSAIYASFPGMSLGRVSNWQLPLPFLQQHSTPALLGMGVKQWRDGDWMCTNCKNHNYASRAECNRCKTTRDILDQDITPTEQS
Protein: Fucosyltransferase (EC 2.4.1.-) (Q6P7E6)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}. Golgi apparatus, Golgi stack membrane {ECO:0000256|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU003832}.
Interaction partners:
Sequence:
MDPLGPAKPQWSWRCCLTTLLFHLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHSIPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQLPRSSRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFKNSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQTRGIAAWFT
Protein: Uricase (EC 1.7.3.3) (Urate oxidase) (P25688)
Organism: Mus musculus (Mouse)
Function: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Subcellular location: Peroxisome {ECO:0000269|PubMed:23085393}. Mitochondrion {ECO:0000269|PubMed:23085393}.
Interaction partners:
- 5-hydroxyisourate hydrolase
- Xanthine dehydrogenase/oxidase
- Peroxisomal targeting signal 1 receptor
- Probable inactive allantoicase
- Solute carrier family 2, facilitated glucose transporter member 9
- Solute carrier family 22 member 12
- Albumin
- Alanine--glyoxylate aminotransferase
- Tryptophan 2,3-dioxygenase
Sequence:
MAHYHDNYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHVLAKLRGIRNIETFAMNICEHFLSSFNHVTRAHVYVEEVPWKRFEKNGIKHVHAFIHTPTGTHFCEVEQMRNGPPVIHSGIKDLKVLKTTQSGFEGFLKDQFTTLPEVKDRCFATQVYCKWRYQRRDVDFEAIWGAVRDIVLQKFAGPYDKGEYSPSVQKTLYDIQVLSLSQLPEIEDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGKITGTVKRKLPSRL
Protein: ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) (Q9NVI7)
Organism: Homo sapiens (Human)
Function: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20332122, ECO:0000269|PubMed:20349121}; Single-pass membrane protein {ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20349121}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:18063578}. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane (PubMed:20154147, PubMed:20349121). The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (PubMed:18063578). Also present at mitochondria-endoplasmic reticulum contact sites; where it interacts with EIF2AK3/PERK (PubMed:39116259). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20349121, ECO:0000269|PubMed:39116259}.
Interaction partners:
- Prohibitin-2
- ATP synthase F
- Prohibitin 1
- Translocator protein
- Stress-70 protein, mitochondrial
Sequence:
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS
Protein: ATP-dependent RNA helicase laf-1 (EC 3.6.4.13) (DEAD-box RNA helicase laf-1) (D0PV95)
Organism: Caenorhabditis elegans
Function: Multifunctional ATP-dependent RNA helicase. Plays a role in RNA remodeling, but is not required for RNA unwinding. Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA. This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in the regulation of transcription and translation initiation. Involved in innate immunity (By similarity). Involved in both stress and inflammatory responses (By similarity). Promotes liquid-liquid phase separation of P granules, which is a process important for intracellular organization and stress granule assembly. Required for embryonic development. Plays a role in sexual cell fate determination by negatively regulating the translation of the sex determining protein tra-2. May play a protective role in the response to heat and oxidative stress. May negatively regulate extrinsic apoptotic signaling pathway via death domain receptors. May be involved in mitotic chromosome segregation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19361491, ECO:0000269|PubMed:26015579}. Cytoplasmic granule {ECO:0000269|PubMed:19361491, ECO:0000269|PubMed:26015579}. Nucleus {ECO:0000250|UniProtKB:O00571}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:O00571}. Inflammasome {ECO:0000250|UniProtKB:Q62167}. Cell membrane {ECO:0000250|UniProtKB:O00571}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O00571}. Note=Localizes to P granules in germline precursor cells. Shuttles between the nucleus and the cytosol (By similarity). {ECO:0000250|UniProtKB:O00571, ECO:0000269|PubMed:19361491}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein A1
- Uncharacterized protein
Sequence:
MESNQSNNGGSGNAALNRGGRYVPPHLRGGDGGAAAAASAGGDDRRGGAGGGGYRRGGGNSGGGGGGGYDRGYNDNRDDRDNRGGSGGYGRDRNYEDRGYNGGGGGGGNRGYNNNRGGGGGGYNRQDRGDGGSSNFSRGGYNNRDEGSDNRGSGRSYNNDRRDNGGDGQNTRWNNLDAPPSRGTSKWENRGARDERIEQELFSGQLSGINFDKYEEIPVEATGDDVPQPISLFSDLSLHEWIEENIKTAGYDRPTPVQKYSIPALQGGRDLMSCAQTGSGKTAAFLVPLVNAILQDGPDAVHRSVTSSGGRKKQYPSALVLSPTRELSLQIFNESRKFAYRTPITSALLYGGRENYKDQIHKLRLGCHILIATPGRLIDVMDQGLIGMEGCRYLVLDEADRMLDMGFEPQIRQIVECNRMPSKEERITAMFSATFPKEIQLLAQDFLKENYVFLAVGRVGSTSENIMQKIVWVEEDEKRSYLMDLLDATGDSSLTLVFVETKRGASDLAYYLNRQNYEVVTIHGDLKQFEREKHLDLFRTGTAPILVATAVAARGLDIPNVKHVINYDLPSDVDEYVHRIGRTGRVGNVGLATSFFNDKNRNIARELMDLIVEANQELPDWLEGMSGDMRSGGGYRGRGGRGNGQRFGGRDHRYQGGSGNGGGGNGGGGGFGGGGQRSGGGGGFQSGGGGGRQQQQQQRAQPQQDWWS
Protein: Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2) (P17509)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-B7
- Homeobox protein Hox-B5
- Homeobox protein Hox-C4
- Homeobox protein Hox-B4
- Homeobox protein Hox-A5
- Homeobox protein Hox-B8
- Homeobox protein Hox-A7
- Homeobox protein Hox-C5
- Homeobox protein Hox-C6
- Homeobox protein Hox-D4
Sequence:
MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE
Protein: Nicotinamide N-methyltransferase (EC 2.1.1.1) (P40261)
Organism: Homo sapiens (Human)
Function: Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification.
Subcellular location: Cytoplasm.
Interaction partners:
- Nicotinamide phosphoribosyltransferase
- Aldehyde oxidase
- NAD-dependent protein deacetylase sirtuin-1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- NAD-dependent protein deacylase sirtuin-6
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
- Purine nucleoside phosphorylase
- NAD-dependent protein deacetylase sirtuin-2
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL