wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear factor 1 (B1AKN7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG
Protein: NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) (A0A8I5Y6B5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
QTHCHSHSGCQPIYLLNEAKRVDNGNRATDDSPPGKKVRTCQKKGPAAGGEDTDRTKGKQDSVKTLLVKGRAPVDPECTSKVGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQQNFSVWMRWGRGKGFMMD
Protein: Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3) (P13207)
Organism: Rattus norvegicus (Rat)
Function: Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location: Secreted.
Interaction partners:
- Endothelin-1 receptor
- Endothelin receptor type B
- Endothelin-1
- Endothelin-2
- Kell metallo-endopeptidase
- Endothelin-converting enzyme 1
- endothelin-converting enzyme 1
- Endoplasmic reticulum membrane adapter protein XK
- Oxytocin receptor
- Beta-2 adrenergic receptor
Sequence:
MELGLWLLLGLTVTSAAAALPAQPGNAGQERGPGRSGDQEEKRVPAHHRPRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNHRGSLRGKRSSGPVPESSQSSPQTRLRCACSGVDDKACAYFCAHVTSYSRRAEKAAAEEKQETGGPRQRLKSRTDKVHQP
Protein: Probable C-mannosyltransferase DPY19L2 (EC 2.4.1.-) (Dpy-19-like protein 2) (Protein dpy-19 homolog 2) (Q6NUT2)
Organism: Homo sapiens (Human)
Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
Subcellular location: Nucleus inner membrane {ECO:0000250|UniProtKB:P0CW70}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with DPY19L2 at the inner nuclear membrane. {ECO:0000250|UniProtKB:P0CW70}.
Interaction partners:
- Spermatogenesis-associated protein 16
- Zona pellucida-binding protein 1
- Sperm acrosome membrane-associated protein 1
- PRKCA-binding protein
Sequence:
MRKQGVSSKRLQSSGRSQSKGRRGASLAREPEVEEEMEKSALGGGKLPRGSWRSSPGRIQSLKERKGLELEVVAKTFLLGPFQFVRNSLAQLREKVQELQARRFSSRTTLGIAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFHLYPEVIIASWYCTFMGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQLGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNFWLIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTTVFQNSVYRVLKVN
Protein: L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (Protein P26h) (Q920N9)
Organism: Cavia porcellus (Guinea pig)
Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.
Interaction partners:
- Sorbitol dehydrogenase
- aldose reductase
- aldose reductase
- aldose reductase
- Carbonyl reductase
Sequence:
MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVRECPGVEPVCVDLADWEATEQALSNVGPADLLVNNAAVALLQPFLEVTKEACVTSFNVNLRAVIQVSQIVAKGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALYMLTKMMALELGPHKIRVNAVNPTVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGSTLPVDGGFLAT
Protein: Formin-like protein 6 (AtFH6) (AtFORMIN-6) (Q9FJX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might be involved in the organization and polarity of the actin cytoskeleton.
Subcellular location: Membrane {ECO:0000269|PubMed:15319477}; Single-pass membrane protein {ECO:0000269|PubMed:15319477}.
Interaction partners:
- Profilin-1
- Profilin-3
- Profilin-4
- Profilin-5
- Profilin-2
- rRNA-processing protein EFG1
- Ubiquitin C-terminal hydrolases superfamily protein
- Transducin family protein / WD-40 repeat family protein
- Rhomboid-like protein 19
- At1g31410
Sequence:
MKALQSRFFFFFFFYIFFSVSVSSEAHRRILHQPLFPESSTPPPPDFQSTPSPPLPDTPDQPFFPENPSTPQQTLFPPPPPPVSADVNGGLPIPTATTQSAKPGKKVAIVISVGIVTLGMLSALAFFLYRHKAKHASDTQKLVTGGGDGGGSRRFQEDSGPPTTTSSTFLYMGTVEPTRVSASESNGGTNGPVNSSPYRKLNSAKRSERYRPSPELQPLPPLAKPPQPSDNSPSALSPSSSSSGEECRDTAFYTPHGSAISSDDGYYTAFPRSANGSLPHSKRTSPRSKFGSAPTTAASRSPEMKHVIIPSIKQKLPPPVQPPPLRGLESDEQELPYSQNKPKFSQPPPPPNRAAFQAITQEKSPVPPPRRSPPPLQTPPPPPPPPPLAPPPPPQKRPRDFQMLRKVTNSEATTNSTTSPSRKQAFKTPSPKTKAVEEVNSVSAGSLEKSGDGDTDPSKPKLKPLHWDKVRASSDRATVWDQLKSSSFQLNEDRMEHLFGCNSGSSAPKEPVRRSVIPLAENENRVLDPKKSQNIAILLRALNVTREEVSEALTDGNPESLGAELLETLVKMAPTKEEEIKLREYSGDVSKLGTAERFLKTILDIPFAFKRVEAMLYRANFDAEVKYLRNSFQTLEEASLELKASRLFLKLLEAVLMTGNRMNVGTNRGDAIAFKLDTLLKLVDIKGVDGKTTLLHFVVQEITRSEGTTTTKDETILHGNNDGFRKQGLQVVAGLSRDLVNVKKSAGMDFDVLSSYVTKLEMGLDKLRSFLKTETTQGRFFDSMKTFLKEAEEEIRKIKGGERKALSMVKEVTEYFHGNAAREEAHPLRIFMVVRDFLGVLDNVCKEVKTMQEMSTSMGSASARSFRISATASLPVLHRYKARQDDTSSDSEHSSNSST
Protein: WT1 transcription factor a (Wilms tumor 1a) (Wilms' tumor suppressor) (Q9PUT7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
- T-box transcription factor 18.
- NPHS2 stomatin family member, podocin.
- NPHS1 adhesion molecule, nephrin.
- Transcription factor 21
- Paired box protein Pax-2a
- GATA-binding protein 4.
- Thymosin beta
- Pre-mRNA-splicing regulator WTAP
- Nuclear receptor subfamily 0, group B, member 1.
- Cellular tumor antigen p53
Sequence:
MGSDVRDLNTLLPPVPPLPGGNGNCTLPVSSTPQWPPMLDFHTGAPYGSLAQHSFIKQEPSWGTADPHEDPHCGLSAFTVHFSGQFTGTGACRYGAFGAPAASQPPPSQPRMFSNSPYLSNCMDSQSSSRNQGYGTVAFDGASNYGHTPSHHTPQFPNHSFKHEDSITQQSNMGDQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSSDNLYQMASQLECMGWNPVNSLASTIKSHPGGYESDPSTPMVYSCSTQYRIHTHGVFRGLQDVRRVPGITPAIVRSTETNEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFTDCGRRFSRSDQLKRHQRRHTGVKPFQCETCQRKFSRSDHLKTHTRTHTGKTSEKPFNCRWPNCQKKFARSDELVRHHNMHQRNLTKLQLTI
Protein: At2g22080 (Transmembrane protein) (Q7XA71)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- NAD
- dCTP pyrophosphatase 1
- Calcineurin b subunit-like protein
- Remorin 4.1
- Uridine nucleosidase 1
- glucan endo-1,3-beta-D-glucosidase
- Methylsterol monooxygenase 1-1
- Cinnamoyl-CoA reductase-like protein
- Probable pectate lyase 3
Sequence:
MELKEQGMSMRLSLVLGNALVLNCAALALTATMLSSLLELFSQVTVLKGDVIENGYEVVDAVEGNGNNDDSGDDGGEDEEGSADDAEGKETKKGPVSDPDLNGEAGDNDDEPEGDDGNDDEDDDNHENDDEDEEEDEDENDDGGEEDDDEDAEVEEEEEEEDEDDEEALQPPKKRKK
Protein: Protein NRT1/ PTR FAMILY 8.1 (AtNPF8.1) (Peptide transporter PTR1) (Q9M390)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Peptide transporter. Mediates the transport of di- and tripeptides. High affinity transporter with low selectivity. No transport of amino acids.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15500465}; Multi-pass membrane protein {ECO:0000269|PubMed:15500465}.
Interaction partners:
- GLABROUS1 enhancer-binding protein-like 1
Sequence:
MEEKDVYTQDGTVDIHKNPANKEKTGNWKACRFILGNECCERLAYYGMGTNLVNYLESRLNQGNATAANNVTNWSGTCYITPLIGAFIADAYLGRYWTIATFVFIYVSGMTLLTLSASVPGLKPGNCNADTCHPNSSQTAVFFVALYMIALGTGGIKPCVSSFGADQFDENDENEKIKKSSFFNWFYFSINVGALIAATVLVWIQMNVGWGWGFGVPTVAMVIAVCFFFFGSRFYRLQRPGGSPLTRIFQVIVAAFRKISVKVPEDKSLLFETADDESNIKGSRKLVHTDNLKFFDKAAVESQSDSIKDGEVNPWRLCSVTQVEELKSIITLLPVWATGIVFATVYSQMSTMFVLQGNTMDQHMGKNFEIPSASLSLFDTVSVLFWTPVYDQFIIPLARKFTRNERGFTQLQRMGIGLVVSIFAMITAGVLEVVRLDYVKTHNAYDQKQIHMSIFWQIPQYLLIGCAEVFTFIGQLEFFYDQAPDAMRSLCSALSLTTVALGNYLSTVLVTVVMKITKKNGKPGWIPDNLNRGHLDYFFYLLATLSFLNFLVYLWISKRYKYKKAVGRAH
Protein: RH21315p (Q8IGH2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGAREDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESNSTIGVEFATRSIEVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLRELRDHADQNIVIMLVGNKSDLRHLRSVPTDEAKLFAERNGLSFIETSALDSTNVETAFQNILTEIYRIVSQKQIRDPPEGDVIRPSNVEPIDVKPTVTADVRKQCCQ
Protein: Axial regulator YABBY 4 (Protein INNER NO OUTER) (Q9LDT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for the formation and the abaxial-adaxial asymmetric growth of the ovule outer integument.
Subcellular location: Nucleus {ECO:0000269|PubMed:12183380}.
Interaction partners:
- Protein SPOROCYTELESS
- Probable transcription factor KAN4
- Transcription repressor KAN1
- Probable transcription factor KAN2
- Transcriptional corepressor SEUSS
- Homeobox protein BEL1 homolog
- Short integuments 2, mitochondrial
- Transcriptional corepressor LEUNIG
- Large ribosomal subunit protein uL14my
Sequence:
MTKLPNMTTTLNHLFDLPGQICHVQCGFCTTILLVSVPFTSLSMVVTVRCGHCTSLLSVNLMKASFIPLHLLASLSHLDETGKEEVAATDGVEEEAWKVNQEKENSPTTLVSSSDNEDEDVSRVYQVVNKPPEKRQRAPSAYNCFIKEEIRRLKAQNPSMAHKEAFSLAAKNWAHFPPAHNKRAASDQCFCEEDNNAILPCNVFEDHEESNNGFRERKAQRHSIWGKSPFE
Protein: Protein CBFA2T1 (Protein MTG8) (Q61909)
Organism: Mus musculus (Mouse)
Function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00440}. Note=Colocalizes with ATN1 in discrete nuclear dots. {ECO:0000250}.
Interaction partners:
- Runt-related transcription factor 1
- CCAAT/enhancer-binding protein alpha
- Nuclear receptor corepressor 2
- Transcription factor PU.1
- Transcription factor 12
- Nuclear receptor corepressor 1
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Paired amphipathic helix protein Sin3a
- Histone deacetylase 1
- Myosin-11
Sequence:
MPDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGDTPAVSSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR
Protein: Conserved protein (O53619)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- cysteine-S-conjugate beta-lyase
- Possible maturase
- Conserved transmembrane protein
Sequence:
MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAVDFAGSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAGDPHAVLVGRARRHAAAALRSGITTIRDLGDRDYAALALREEYRQKTTVGPELVVSGPPLTRSGGHCWFLGGVADSVEELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVWCGMTIPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSGTQVPLQASAVGYNTPS
Protein: Formin-like protein (Formin related in leukocytes) (Q9VUC6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies.
Interaction partners:
- Cdc42 homolog
- Ras-related protein Rac1
- Dishevelled associated activator of morphogenesis, isoform D
- Ras-like GTP-binding protein Rho1
- Protein diaphanous
Sequence:
MGAVKSRTITSADVDADEQLQHPHSHAHHHSMRNGHQHNGSISSGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSRTLEEMDC
Protein: Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form] (O54907)
Organism: Mus musculus (Mouse)
Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted {ECO:0000250}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 12A
- Tumor necrosis factor receptor superfamily, member 25
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 13
- Tumor necrosis factor ligand superfamily member 13B
- Tumor necrosis factor receptor superfamily member 10B
- CD40 ligand
- TNF receptor-associated factor 2
- Fibroblast growth factor 22
- Fibroblast growth factor 16
Sequence:
MAARRSQRRRGRRGEPGTALLAPLVLSLGLALACLGLLLVVVSLGSWATLSAQEPSQEELTAEDRREPPELNPQTEESQDVVPFLEQLVRPRRSAPKGRKARPRRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEETKINSSSPLRYDRQIGEFTVIRAGLYYLYCQVHFDEGKAVYLKLDLLVNGVLALRCLEEFSATAASSPGPQLRLCQVSGLLPLRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH
Protein: Thrombopoietin (B5L331)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MESNVTGDFMLSLGMDLNRVLVVVFSMVVSELSHVHTRPIDFVCDSEARRVMNKVKDLQEEKVICSGVDALPSSIQLPCISIHKATWERKSVQERRAEILLSLGTLAQDVRSARTLSQPGCGLTLLKRLEHSINNYLHVVRLLHVEGEQEGPAVERCLGQPSKDLGLVLKYFGLLLTGKLELLIAEMAKWC
Protein: Ciliary microtubule-associated protein 3 (Protein pitchfork) (Q8TCI5)
Organism: Homo sapiens (Human)
Function: During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.
Subcellular location: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9D9W1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9D9W1}. Cytoplasm {ECO:0000250|UniProtKB:Q9D9W1}. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. {ECO:0000250|UniProtKB:Q9D9W1}.
Interaction partners:
- G-protein coupled receptor-associated sorting protein 2
Sequence:
MCFSRADAADNYPFGTCQQRKLFPHFHPPNLIGNKFVPLRGSPHRGPGCYFSDGYGLAYDLSKIPTSIKGYTLGARTAVRFKPIQKEMTPHAGRYQKVSPQQEKHKQNFAPFNVLVPRFKNYPKDTYYPSPGAYNPEKKPPPKIAWPMKFGSPDWAQVPCLQKRTLKAELSTDKDFRKHRNRVAYLSLYYN
Protein: Uncharacterized protein (Q386V1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNDWITKALEEKQILSLPSLADVKGVFCVAREHEWYDDCVVMDWTALHRGLRPSTSSFNPTVAVAEVMRFGCELEGDGSLATALELRTPWCVVPLAEQAQRLSVFLHPSGANVKPYMFCRGPPGQRSVRDDLHSVLQGVQRQLRDSGIRCHVFFGSVIVVSDDFEHLMHLTAAVYRALKSAGIELNANASSFEPRRVFRTAGGLCWNTLSPISLKSVDNMAALLVDLFYMWLGDFYLWLCVTPPESLLGVAGRDEDKMKVFRDFIVKRVVPNCECIEFNGLADVDVEELLTAAKPLLKRKLPLVGPQKWSALELRLCLAALKAYEHPPP
Protein: Proofreading thioesterase EntH (EC 3.1.2.-) (Enterobactin synthase component H) (p15) (P0A8Y8)
Organism: Escherichia coli (strain K12)
Function: Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Displays esterase activity toward a wide range of substrates, including acyl-CoAs and aryl-CoAs.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00907, ECO:0000269|PubMed:17675380}.
Interaction partners:
- Enterobactin synthase component B
- 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
- Enterobactin synthase component E
- Isochorismate synthase EntC
- Enterobactin synthase component F
- Ferrienterobactin receptor
- Enterobactin synthase component D
- Ferric enterobactin-binding periplasmic protein FepB
- Uncharacterized protein YncE
- Iron
Sequence:
MIWKRHLTLDELNATSDNTMVAHLGIVYTRLGDDVLEAEMPVDTRTHQPFGLLHGGASAALAETLGSMAGFMMTRDGQCVVGTELNATHHRPVSEGKVRGVCQPLHLGRQNQSWEIVVFDEQGRRCCTCRLGTAVLG
Protein: Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 7C member 5) (Protein SDR7C5) (Q6UX07)
Organism: Homo sapiens (Human)
Function: Putative oxidoreductase.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSPQSSPDLSKMTHRIQAKVEPEIQLS
Protein: Glucose-6-phosphate dehydrogenase, putative (Q10814)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTVASTAHHTRRLRFGLAAPLPRAGTQMRAFAQAVEAAGFDVLAFPDHLVPSVSPFAGATAAAMATQRLHTGTLVLNNDFRHPVDTAREAAGVATLAEGRFELGLGAGHRRSEYDAAGITFDSGATRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEAGSLVAPPKVRVPLLVGGNGTEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLADRIAVVRHAAGDRFEAIELNALIQAVVCTNDRNAAAAELAATLGGITPEQVLESPFLLLGTHEQMAEALAARQRRFGVSYWTVFDEWAGRASAMRDIAEVIALLRYG
Protein: Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2) (Q86WK6)
Organism: Homo sapiens (Human)
Function: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q80ZD8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q80ZD8}. Perikaryon {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80ZD7}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.
Interaction partners:
- Potassium voltage-gated channel subfamily B member 1
Sequence:
MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHLGDTLIIKCDTKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV
Protein: Protein orai-3 (Transmembrane protein 142C) (Q6P8G8)
Organism: Mus musculus (Mouse)
Function: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9BRQ5}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with STIM1 upon store depletion. {ECO:0000250|UniProtKB:Q9BRQ5}.
Interaction partners:
- Stromal interaction molecule 1
- Stromal interaction molecule 2
- Protein orai-2
- Calcium release-activated calcium channel protein 1
- Short transient receptor potential channel 3
- Short transient receptor potential channel 1
- Short transient receptor potential channel 6
Sequence:
MKGGEGDTGEQAPLNPEVDSPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLENDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPMGKPAPVVPMSQVPPVTVSLSLASNLTPSSASITTSQQPSKACPPRQVCDSAHGPGWQAAMASTAIMVPVGLVFMAFALHFYRSLVAHKTDRHKQELEELSRLQGELQAV
Protein: Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase polypeptide VII) (Cytochrome c oxidase subunit AED) (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) (P00429)
Organism: Bos taurus (Bovine)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}; Peripheral membrane protein {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}; Intermembrane side {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}.
Interaction partners:
- Cytochrome b-c1 complex subunit 9
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome c oxidase subunit 7A1, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 2
- Cytochrome b-c1 complex subunit 8
Sequence:
MAEDIQAKIKNYQTAPFDSRFPNQNQTRNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRVYKSLCPISWVSTWDDRRAEGTFPGKI