wanglab/gogpt-training-data huggingface dataset:
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q5TG12)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Protein: ADP/ATP translocase (ADP,ATP carrier protein) (Q388C4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU368008}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU368008}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MTDKKREPAPKLGFLEEFMIGGVAAGLSKTAAAPIERVKLLVQNQGEMMKQGRLDKPYNGVVDCFRRTISTEGVYPLWRGNLSNVLRYFPTQALNFAFKDKFKRMFNYKKEKDGYGKWFMGNMASGGLAGAASLCFVYSLDYVRTRLANDTKSVKGGGERQFNGIVDCYVKTWKSDGIAGLYRGFVVSCIGIVVYRGFYFGLYDTLQPMLPVDTFIVNFFLGWAVTIVAGLLSYPLDTVRRRMMMTSGAAVKYKNSMDCMLQVIKQEGAASLMRGAGANILRGIAGAGVLSGVDALKPIYVEWRRSN
Protein: trypsin (EC 3.4.21.4) (A1Z8J8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Bazooka, isoform B
Sequence:
MLKFVILLSAVACALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQSVSASVLQIRAGSSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKINGALTFSSTIKAIGLASSNPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAAASGKDACQGDSGGPLVSGGVLVGVVSWGYGCAYSNYPGVYADVAALRSWVINNA
Protein: Os08g0432800 protein (cDNA clone:002-137-H01, full insert sequence) (Q6ZA99)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MWEAVGGGDGTALLPWPGSAAAAPLYMPPAAAAAAPFAAGEQLPVEQPFYFDGGGGVAGHNHHPHHHQYGMEAPPPMTMMQMGGGGSSSSRMVVSGLLGTLQAELGRMTAKEIMDAKALAASRSHSEAERRRRQRINGHLARLRSLLPNTTKTDKASLLAEVIEHVKELKRQTSAMMEDGAAGGEAAAAPVVLLPTEDDELEVDAAADEGGRLVARASLCCEDRADLIPGIARALAALRLRARRAEIATLGGRVRSVLLIAAVEEEDPDEAGNDDDGEHGYGVAASHRRHELVASIHEALRGVMNRKAASSDTSSSGAGGGGGSIKRQRMISAHDQQGSFNSSGW
Protein: Carbonic anhydrase (EC 4.2.1.1) (R4GDY8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Regulator of G protein-signaling 14a.
- Nanos homolog 3
- Dead end protein 1
Sequence:
MMTVILTCLATYFLHMVCSVSGSISWCYHSPSCSEVTWPIIAEKHCNGTQQSPINIVTANVKANANLTSFTYVGYNDSTALTVIKNTGTSIQVTLDPKKMRVAGGNLPGRFASTEFHLHWGNGSAMPGSEHTVNGKRFPMELHIVNKPVSNTSDSLAVLGVFIEASNETGKPESWKTLTSYLTRIVKAGDKASLFRNFSMDDLLSGVDRTKYYRYLGSLTTPNCNEGVIWTVFKDPIRVSRDLIDLFSTTVYINNSSNSPLMTNIFRSVQPVNGRIVMSQVAGTKTPGLLNPTSIAANLSPSLMYPILSLTFLYCVLAFL
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (E7F118)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- ABC-type glutathione-S-conjugate transporter
- Multidrug resistance-associated protein 1
- Ectonucleotide pyrophosphatase/phosphodiesterase 1
- Gamma-glutamyl carboxylase.
Sequence:
MDTFCSLSGLDPLWDWNQTWYTHRPELSNCFQNTVLVWAPCIYLWVLSPFYCLHLYCHGRGRLPLSSLCNAKLLLGFFLASFGFVEFFYILLERRLEIHQHLVFLLSPIMRSLTVVLAVCVIHWERVRGCRSSVFLFFFWLLGVLCSIIPLHAKVQLAVEQGLSPDIVRYLAFFSYFALQLAQLFLSCFADQAPLGKAVHKNACPVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLEEEWTAKRTKLQQQENHMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTLARSFGPYFLTGTLCLIVHDVFMFSVPQVLSLLLGFMKDEDTPLWKGYFYATLMFLLSCLQSVFNHQYTYTCFTVGMRVKTAVMGLVYRKSLVMNSSARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEVTLCLFFLWQHLGPSALAGIATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKTLKKSQILYSVSLASFNSSSFLIAFAMFGVYVLIDDKNVLDAQKIFVSMALINILKTPLSQLPFAMSTTMQALVSLKRLGKFLCQDELKPDNVARESFKSDVDGVVFDNGTFSWSKDGPPCLKRISVKVPCGSLVAVVGHVGSGKSSLLSAMLGETEKRSGTVSVKGSIAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKTRVLVTHGMSFLPQADLILVLVDGEISERGSYQELLNRNGAFADFIHTFANSERKECFSEALQRGSRKSVRLSVTDYMPFSRDLSQEQLIGGDTNSIAIEPLPDSDEDHIPEDLGKLTKVDKARIGRVKLEMYIEYFRTIGLPLIISIVFLYAFQQAASLSNNYWLSLWADQPVINGTQLNTDLKLGVYGALGFAQGISIFGTTVAISLGCIIASRHLHLDLLNNVLHSPMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLKMMLSYFFKLTEVCIIVLMATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNETVQGASVIRAFNEQSRFIMGANHKVDHNQTAYFPRFIATRWLGVNLEFLGNGIVLAASILSVMAKGTLSPGMVGLAVSHSLQVTGFLSWIVRSWTDVENNIVSVERVKEYADTPKEAAWSIEGSSLPPSWPQTGTIEFQDYGLQYRKGLELALKGISVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYIDGINIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVSELPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTIAHRLNTIMDYTKVIVMDKGHVVEMDSPSNLIAKRGQFYYMCREAGLL
Protein: 2-Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase) (LCHAO) (Q07523)
Organism: Rattus norvegicus (Rat)
Function: Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate, 2-hydroxyoctanoate, 2-hydroxyhexanoate and 2-hydroxybutanoate, to the correspondong 2-oxoacids. Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (By similarity). Can also use mandelate as substrate. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.
Subcellular location: Peroxisome.
Interaction partners:
- Alanine--glyoxylate aminotransferase
- Glyoxylate reductase/hydroxypyruvate reductase
- 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- 2-Hydroxyacid oxidase 1
- Catalase
- Glycerol-3-phosphate phosphatase
- D-amino-acid oxidase
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- 2-hydroxyacyl-CoA lyase 1
- Diphosphomevalonate decarboxylase
Sequence:
MPLVCLADFKAHAQKQLSKTSWDFIEGEADDGITYSENIAAFKRIRLRPRYLRDMSKVDTRTTIQGQEISAPICISPTAFHSIAWPDGEKSTARAAQEANICYVISSYASYSLEDIVAAAPEGFRWFQLYMKSDWDFNKQMVQRAEALGFKALVITIDTPVLGNRRRDKRNQLNLEANILLKDLRALKEEKPTQSVPVSFPKASFCWNDLSLLQSITRLPIILKGILTKEDAELAMKHNVQGIVVSNHGGRQLDEVSASIDALREVVAAVKGKIEVYMDGGVRTGTDVLKALALGARCIFLGRPILWGLACKGEDGVKEVLDILTAELHRCMTLSGCQSVAEISPDLIQFSRL
Protein: Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) (P27338)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Interaction partners:
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase
- Aromatic-L-amino-acid decarboxylase
- Dopamine beta-hydroxylase
- Amine oxidase [copper-containing] 2
- Aldehyde dehydrogenase, mitochondrial
- Amine oxidase [copper-containing] 3
- Diamine oxidase [copper-containing]
- E3 ubiquitin-protein ligase parkin
- Aldehyde oxidase
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (H0Y6P5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWP
Protein: Signal recognition particle subunit SRP72 (Q387W1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR038922}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
- SRP19 protein
- Signal recognition particle 54 kDa protein
- Signal recognition particle subunit SRP68
- Signal recognition particle receptor alpha subunit, putative
- Signal recognition particle receptor subunit beta
- 60S ribosomal protein L4
- 60S ribosomal protein L7a
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L13a, putative
- 60S ribosomal protein L19, putative
Sequence:
MSDVSKFVRQLERLVETGAEPSKILPAIDKILFVGSKNTFALRCKVVCLLHQDKHAAALATLEQLAATDPSLGNKSQEYAFHKAYCHYRLFDDRQAQMVLSRAPHTANHVPSQHLLAQAHYRLEEFEEAANIYEELLKNERFRDEQEKAELLTNYTAACTAMDVQRTQAIVRSADVKNADMLYNVATAQLEVQDYAAATQTLKQAEMVCARAHPESQLRSFEDVCSKVDDELRALLDAKGSPERAFFDDVANIWVQMAFVHHAIHHEEKAAALLTFVLKYRPPSEVTLAVASINWAAIQRHKDFFDTYRKLKSAQNPAVNNRLTSRQRLLVHYNIAMLLLNTGNFTRFKRQVELVASDYPDADLTHALKLALAVGETKKKKQSGDKTVSEYLDNYKKSVAAQQQQQQRKPAVGRMLPLIAAQIFLDNSDLERAIESLSSAADDIQRRPCTLMTLFTWKVQLGDISGGKQLLKEYAGAAMKNVDVVKTITLWAVRFLSARGLYADGVDVIQDAQRVAAALQQDREVLALMALCLSYYDMQAARSCIAGIPDADNKTGAPSGKITSSFIKELEAQQPSRQRIESFGYRRVVEDDEEGDGGPKAKRAGRRARPMRRPPKNAESRIDPERWIPMSHRSYIKDLPERRKRELKRLRAIEQEQKRRLAEKRKVATATADPSS
Protein: MIP18 family protein C144.16 (Q9UTL0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in chromosome segregation through establishment of sister chromatid cohesion.
Interaction partners:
- Probable cytosolic Fe-S cluster assembly factor SPAC806.02c
- DNA repair/transcription protein mms19
- Cytosolic Fe-S cluster assembly factor NAR1 homolog
- Fe-S cluster assembly protein dre2
- Cytosolic Fe-S cluster assembly factor nbp35
- NADPH-dependent diflavin oxidoreductase 1
- General transcription and DNA repair factor IIH helicase subunit XPD
- GrpE protein homolog
- LTO1 family protein C191.08
- Ribose-5-phosphate isomerase
Sequence:
MSANLQNENPEVKELNQLPSRVEEEEDLLLSSTKQWLTEIESEQTNIKEERDPIDPQEIYDLLAKINDPEHPLTLAQLSVVKLEDIEVVDNVEGDSYITVHITPTIPHCSMCTLIGLCIRVRLERCLPPRFHVDVKVKKGTHASESQVNKQLNDKERVAAACENEQLLSVLNGMMATCV
Protein: Ecdysone-induced protein 63E, isoform N (EC 2.7.11.22) (M9PE01)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cyclin Y, isoform A
- PFTAIRE-interacting factor 1A, isoform H
- G2/mitotic-specific cyclin-B
- G2/mitotic-specific cyclin-B3
- Cell division cycle 14, isoform A
- Cell division control protein
- FI13065p
- Tyrosine-protein kinase hopscotch
- Cyclin G
- Rho guanine nucleotide exchange factor 2, isoform D
Sequence:
MATTTTTTTTTGATNAKDGVTMREKKGGALQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRGGHGGHHNHGNKVPYNGYNSEEYLDRLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTDHHDRVQRQLSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEPNRQNKXKLKQVLSVDGVRFYC
Protein: Choriogonadotropin subunit beta variant 2 (Q6NT52)
Organism: Homo sapiens (Human)
Subcellular location: Secreted.
Interaction partners:
Sequence:
MSKGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ
Protein: Cyclic GMP-AMP synthase (NvcGAS) (cGAMP synthase) (cGAS) (nv-cGAS) (EC 2.7.7.86) (3'3'-cGAMP synthase) (A7SFB5)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (By similarity). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates v1g246111/STING (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8C6L5}.
Interaction partners:
Sequence:
MATLERLLDLLREYHLDDVLFHNSTPELGIQHRSRPKQKRIIRGKKQQKSKKLKRNEQQQPFPKGDLETLRRFSVTDVKISKQSTKWAKKMADKHLEIIRKHCKTNSIKLFNHFEYTGSFYEHLKTIDADELDIMVALSIKMDELEVEQVTPGYAGLKLRDTPSNRNKYNDLTIADNYGRYLSPEKVSRWFFSLVQKAVNTYKDEIPQTEVKLTDNGPATTLVITYREGDKPQEKNRRLSIDLVPALLFKDKTKPAGDDLRAWHYVAKTIPKGARLKEPLPFRSELLWRQSFSLKEKHLMDKLDKDDNGCRREMVRIVKTIVKKDPTLAQLSSYHIKTAFLQYNFSDVKLDWEGKKLAERFLHFLEFLRDRVKDKTLNNYFITDLNLLDDLNDSNIDNIANRLDKIIQNETERAKIFTTQRQ
Protein: Histone H3 (D2XB48)
Organism: Marseillevirus marseillevirus (GBM)
Interaction partners:
Sequence:
MARKNLVQSFSLVQTVMSKAGKKVKAQQHGHLADHVSVGETQIPKASTQHLLRKAGSLSAAGDTEVPIRGFVHMKLHKLVQKSLLAMQLAKRKTIMKSDVKKAAELMHLPVFAIPTKDSGAKGSVFLSCRQKGAGSAGTGSETNSQEVRSQMRSTCLIIPKERFRTMAKEISKKEGHDVHIAEAALDMLQVIVESCTVRLLEKALVITYSGKRTRVTSKDIETAFMLEHGPL
Protein: Transcription factor MYB78 (Myb-related protein 78) (AtMYB78) (Q9FGY3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Putative defensin-like protein 162
- Putative defensin-like protein 131
Sequence:
MGDKGRSLKINKNMEEFTKVEEEMDVRRGPWTVEEDLELINYIASHGEGRWNSLARCAELKRTGKSCRLRWLNYLRPDVRRGNITLEEQLLILELHTRWGNRWSKIAQYLPGRTDNEIKNYWRTRVQKHAKQLKCDVNSQQFKDTMKYLWMPRLVERIQAASIGSVSMSSCVTTSSDQFVINNNNTNNVDNLALMSNPNGYITPDNSSVAVSPVSDLTECQVSSEVWKIGQDENLVDPKMTSPNYMDNSSGLLNGDFTKMQDQSDLNWFENINGMVPNYSDSFWNIGNDEDFWLLQQHQQVHDNGSF
Protein: HCG38228, isoform CRA_b (Rap guanine nucleotide exchange factor 5 isoform 2) (A0A0S2Z561)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSSRLRVFDPHLERKDSAAALSDRELPLPTFDVPYFKYIDEEDEDDEWSSRSQSSTEDDSVDSLLSDRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV
Protein: Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5) (P19969)
Organism: Rattus norvegicus (Rat)
Function: Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}. Cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}.
Interaction partners:
- Trafficking kinesin-binding protein 2
- Vesicle-fusing ATPase
- Inactive phospholipase C-like protein 1
- Huntingtin-associated protein 1
- Gamma-aminobutyric acid receptor subunit beta-1
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit beta-2
- Gamma-aminobutyric acid type B receptor subunit 1
- Gamma-aminobutyric acid receptor-associated protein
Sequence:
MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQLPGGTGNAVGTASIRASEEKTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK
Protein: Hemopexin (Beta-1B-glycoprotein) (P02790)
Organism: Homo sapiens (Human)
Function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
Subcellular location: Secreted.
Interaction partners:
- Prolow-density lipoprotein receptor-related protein 1
- Haptoglobin
- Albumin
- Metalloproteinase inhibitor 2
- Scavenger receptor cysteine-rich type 1 protein M130
- Protein AMBP
- Alpha-1-antitrypsin
- Ceruloplasmin
- Alpha-2-HS-glycoprotein
- 72 kDa type IV collagenase
Sequence:
MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSANGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH
Protein: Probable methyltransferase PMT25 (EC 2.1.1.-) (Q0WT31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Transmembrane 9 superfamily member 9
- Vacuolar-sorting receptor 5
- Probable pectinesterase/pectinesterase inhibitor 61
Sequence:
MAMGKYSRVDGKKSSSYGLTITIVLLLSLCLVGTWMFMSSWSAPADSAGYSSTDTAKDVSKNDLRKEEGDRDPKNFSDEKNEENEAATENNQVKTDSENSAEGNQVNESSGEKTEAGEERKESDDNNGDGDGEKEKNVKEVGSESDETTQKEKTQLEESTEENKSEDGNGNEEKAEENASETEESTEKSSKEVFPAGDQAEITKESSTGDGAWSTQLVESQNEKKAQQSSISKDQSSYGWKTCNVTAGPDYIPCLDNWQAIKKLHTTMHYEHRERHCPEESPHCLVSLPDGYKRSIKWPKSREKIWYNNVPHTKLAEIKGHQNWVKMSGEHLTFPGGGTQFKNGALHYIDFIQQSHPAIAWGNRTRVILDVGCGVASFGGYLFERDVLALSFAPKDEHEAQVQFALERGIPAMLNVMGTKRLPFPGSVFDLIHCARCRVPWHIEGGKLLLELNRALRPGGFFVWSATPVYRKNEEDSGIWKAMSELTKAMCWKLVTIKKDKLNEVGAAIYQKPTSNKCYNKRPQNEPPLCKDSDDQNAAWNVPLEACMHKVTEDSSKRGAVWPNMWPERVETAPEWLDSQEGVYGKPAPEDFTADQEKWKTIVSKAYLNDMGIDWSNVRNVMDMRAVYGGFAAALKDLKLWVMNVVPVDAPDTLPIIYERGLFGIYHDWCESFNTYPRTYDLLHADHLFSTLRKRCNLVSVMAEIDRILRPQGTFIIRDDMETLGEVEKMVKSMKWKVKMTQSKDNEGLLSIEKSWWRPEETETIKSAIA
Protein: Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) (P99028)
Organism: Mus musculus (Mouse)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Intermembrane side {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
Interaction partners:
- Cytochrome b-c1 complex subunit 10
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 7B, mitochondrial
Sequence:
MGLEDERKMLTGSGDPKEEEEEELVDPLTTVREHCEQLEKCVKARERLELCDNRVSSRSQTEEDCTEELFDFLHARDHCVAHKLFKNLK
Protein: F-box protein SKIP23 (SKP1-interacting partner 23) (Q3EBZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- F-box/LRR-repeat protein 14
- Uncharacterized protein At4g25920
- At1g30160
Sequence:
MVDWSTLPKDLLDLISKSLESSFDLIQFRSVCSSWRSAAEPKSPLPTHHLPILPDNGGSLFPDSAVGFRLSQRSILLIKPHEPCIESDSFGWLIKVEEDLNVPRKVTLLDPLCDTRNSIPENFPRVLDMSKFKVRELGREFKLHYFNTVGDIVESLYLEKAVVKYLDCDGDYKFVLLTIHVSGKLAVFRSWDRAWTVINDMPSPYDDVMLFDGRFFAVDNNGRTVVVDYSSLKLTLVASPVFGGDKKFLIESCGEMLLVDMYLSLEAVEGDPGFVEEIFEHPAFYMNERTVKFKVYRFVEREESWVDVYDLEDKMLFLGDDSTFSASASDILPLCDGSSVFFNGNVFNGEDLGAMQDRDLGVFDFRSGKIELVQKLPEYAKLFWPPPPWITSHARAEDHIGETSSQS