wanglab/gogpt-training-data huggingface dataset:
Protein: Protocadherin related 15 (F1LXN4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Cadherin-23
- LHFPL tetraspan subfamily member 5 protein
- USH1 protein network component harmonin.
- Myosin VIIA
- USH1 protein network component sans
- Whirlin
- Transmembrane channel-like protein
- Transmembrane channel-like protein
- Usherin
- Calcium and integrin-binding family member 2
Sequence:
MSPQFALWKCMPHGILLASLLIVSWGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFAGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFLHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDVPPGGVPTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYNVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGSKGDFVINRTTGLVSIAPGVELVVGQTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAVLLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTAFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVYSIVAGNEDDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFTSVLRVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQSAMPAAKPAAPVPAAPPPPPPPPPPGAHLYEELGESAMYEMPQYGSRRRLLPPAGQEEYGEVIGEAEEEYEEEEEKPEKVKKPKVEIREPSEEEVVVTVEKPPAAEPTYPTWKRARIFPMIFKKVRGLAEKRGIDLEGEEWRRRLEEEDKDYLQLTLDQEEATESTVESEEESSDYTEYTETESEFSESETTEESESETPSEEAEESSTPESEESESTESEGEKARKNIVLARRRPVVEEIQEVKGKKEEPPVEQEEEPPGEEEERPEEGEESEAAPMDESTDLEAQDVPEEGSAESASVERGVESEEESESEVSSSSSSSSSESLSGGPWGFQVPEYDRRKEEDAKKSPGANSEGYNTAL
Protein: Serpin B10 (TGF-beta-repressible serine proteinase inhibitor) (Trespin) (Transforming growth factor beta repressible serpin) (Q8K3K4)
Organism: Rattus norvegicus (Rat)
Function: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Inhibits plasmin.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:11986314}.
Interaction partners:
- Cathepsin G
- Granzyme-like protein 2
Sequence:
MASLAVSINQFAVEFSKKLAESAEGRNIFFSPWGISTSLAMVYLGTKGTTAAQMSQVLHFGSIQDFKFGPDSEKKRKMECHSGKSEEMQSDFQTLTAKILKHGNSYVLKIANRIYVEKTYLFHNKYLEDMKTYFGAEPQSVNFVEASGQIRKEINSWVGSQTGDKIPNLLPDDAVDNKTTMVLVNALYFKGTWEHQFSVQNTTERPFRINKTTSKPVQMMSMKQSLQVFHIEELQTIGVQLHYQNREFSLLLLLPEEVEGLKQLERAITYEKLDKWTSADMMDTYEVRLYLPKFKMEESYDLQSALRDMGMTDAFNQGKANFSNMTSERNLFLSNVFHKTFLEINEEGTEAAAGTGSEVNFRIKAPSIELNADHPFLFLIRHNVTNTILFDGRFYSP
Protein: Transcription factor sox-2 (Q21305)
Organism: Caenorhabditis elegans
Function: Probable transcription factor that regulates the lineage progression of embryonic blast cells and controls the postmitotic specification and differentiation of neurons. Cooperates with additional factors to direct the differentiation of the olfactory neurons, functioning with the transcription factor ceh-36 to specify AWC neurons and with the LIM homeodomain factor lim-4 to suppress AWC terminal differentiation and promote AWB neuron differentiation. Plays a role in the terminal differentiation of glutamatergic and cholinergic neurons. Required for natural reprogramming events and in particular for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Protein lin-28
- Homeobox protein ceh-6
- Paired box protein 3 homolog
- Protein phosphatase eya-1
- C2H2-type domain-containing protein
- Neurogenic differentiation factor 1
- Kruppel-like factor 2
- Spalt-like protein sem-4
- Helix-loop-helix protein ngn-1
- Protein lin-12
Sequence:
MMMDPDSAKMQDYSGWSFGFHMPPTSSTNLLPQSMPDDLSNGPDSPDSTGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPIPFGNLDTKTPSYPTLTTNWNATNQYIDQFRFAPYPTTTVMDQIPFSLTYPVHSVPTDNSSPSQFQPSPMSTNFAGSYLTPKSESSPVGSDSTVGTVDSSQFRAYYDHTKDQMMYPYSIELTHAQNIQNALSQSHVTS
Protein: Adenosylhomocysteinase (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) (P9WGV3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00563}.
Interaction partners:
- Methionine synthase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- O-succinylhomoserine sulfhydrylase
- Probable cystathionine beta-synthase Rv1077
- Cystathionine gamma-synthase
- S-adenosylmethionine synthase
- Probable O-acetylhomoserine sulfhydrylase MetC
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- S-methylmethionine:homocysteine methyltransferase
- Putative cystathionine beta-lyase
Sequence:
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
Protein: 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (P33207)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast. Plastid. Note=And non-photosynthetic plastids.
Interaction partners:
- EMBRYO DEFECTIVE 3147
- 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Beta-ketoacyl-[acyl-carrier-protein] synthase III, chloroplastic
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- NAD
- AT4g13180/F17N18_70
Sequence:
MAAAVAAPRLISLKAVAKLGFREISQIRQLAPLHSAIPHFGMLRCRSRQPFSTSVVKAQATATEQSPGEVVQKVESPVVVITGASRGIGKAIALALGKAGCKVLVNYARSAKEAEEVAKQIEEYGGQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLIRMKQSQWDEVIALNLTGVFLCTQAAVKIMMKKKRGRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINVNVVCPGFIASDMTAELGEDMEKKILGTIPLGRYGKAEEVAGLVEFLALSPAASYITGQAFTIDGGIAI
Protein: Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19) (P19001)
Organism: Mus musculus (Mouse)
Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).
Interaction partners:
- Keratin, type II cytoskeletal 8
- Keratin, type I cytoskeletal 18
- Epithelial cell adhesion molecule
- Prominin-1
- Hemoglobin subunit beta-H1
- Dystrophin
- Keratin, type II cytoskeletal 7
- Alpha-fetoprotein
- Utrophin
- Dystroglycan 1
Sequence:
MTSYSYRQTSAMSSFGGTGGGSVRIGSGGVFRAPSIHGGSGGRGVSVSSTRFVTSSSGSYGGVRGGSFSGTLAVSDGLLSGNEKITMQNLNDRLASYLDKVRALEQANGELEVKIRDWYQKQGPGPSRDYNHYFKTIEDLRDKILGATIDNSKIVLQIDNARLAADDFRTKFETEHALRLSVEADINGLRRVLDELTLARTDLEMQIESLKEELAYLKKNHEEEITALRSQVGGQVSVEVDSTPGVDLAKILSEMRSQYEIMAEKNRKDAEATYLARIEELNTQVAVHSEQIQISKTEVTDLRRTLQGLEIELQSQLSMKAALEGTLAETEARYGVQLSQIQSVISGFEAQLSDVRADIERQNQEYKQLMDIKSRLEQEIATYRSLLEGQEAHYNNLPTPKAI
Protein: Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) (Q3V3R1)
Organism: Mus musculus (Mouse)
Function: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:15611115}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Bifunctional purine biosynthesis protein ATIC
- Serine hydroxymethyltransferase, mitochondrial
- Serine hydroxymethyltransferase, cytosolic
- Dihydrofolate reductase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
- Aminomethyltransferase, mitochondrial
- Methionine synthase
- Formimidoyltransferase-cyclodeaminase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
Sequence:
MSVRLPLLLRQLGRQQLPSGPACRLRELCRSGSRSSSSGGGDPEGLRGRRLQDGQTFSSHGPGNPEAPGMDSIVRDVIHNSKEVLSLLQEKNPAFKPVLVVIQAGDDNLMKDMNQNLAKEAGLDITHICLPPDSGEDEIIDEILKINEDPRVHGLTLQISEDSLSNKVLNALKPEKDVDGVTDINLGKLVRGDAPECFVSPLAKAAVELVEKSGITLDGKKVLVVGAHGPLEAALQWLFQRKGSMTMSCPWATPQLPDKLREADIVVLGSPKPEEIPAVWIPSGTTILNCFHDFLSGKLSGGSPGVPVDKLIAEESVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVQLSLLERLKDQTDGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLKVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHESTQTDKALYNRLVPLVNGVREFSEIQLSRLKKLGIHKTDPSTLTEEEVRKFARLNIDPATITWQRVLDTNDRFLRKITIGQGSTEKGYSRQAQFDIAVASEIMAVLALTDSLTDMKERLGRMVVASDKDGQPVTAEDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSAGGKGSVDLARAVREAANKRSRFQFLYDVQLPIVEKIRVIAQTVYGAKDIELSPEAQSKIDRYTQQGFGNLPICMAKTHLSLSHEPDKKGVPRDFTLPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKGLF
Protein: Hyaluronidase (EC 3.2.1.35) (G3V6V8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Beta-glucuronidase
- Alpha-L-iduronidase
- Arylsulfatase B
- Hyaluronan synthase 2
- CD44 antigen
- Albumin
- hyaluronan synthase
- Factor VII-activating protease
- Receptor-type tyrosine-protein phosphatase C
Sequence:
MQLLSEGQLRRCVVQPVHLTSGLLIFFILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLIKYNLAVNLKVFQMVGSPRLKDRRQNVVIFYANKLGSYPWYTSEGVPINGGLPQNTSLQVHLEKAYQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTKDIYRQKSRTLISDMKENISTADIEYLAKATFEKSAKAFMEETIKLGIKSRPKGFWGYYLYPDCHNYNFYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLHFSQFRVRESLRISTMTSHDYALPVFVYTRLGYKEEPLLFLSKQDLISTIGESAALGAAGIVVWGDMNLTSSAENCTKVNRFVNSDFGSYVINVTTAAEVCSRHLCKNNGRCARKTWKAAHYLHLNPASYHIEASADREFVVKGRASDADLAAMAENFLCHCYEGYEGADCRDMTEASGPSGVSVSSSSVITLCLIALAGHQSIQL
Protein: FMRFamide-like neuropeptides 22 [Cleaved into: SPSAKWMRF-amide 1; SPSAKWMRF-amide 2; SPSAKWMRF-amide 3] (Q93702)
Organism: Caenorhabditis elegans
Function: FMRFamides and FMRFamide-like peptides are neuropeptides.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 16
- FMRFamide-like neuropeptides 7
- Neuropeptide receptor 22
- FMRFamide-like neuropeptides 6
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 1
- FMRFamide-like neuropeptide 18
- FMRFamide-like neuropeptides 19
- FMRFamide-like neuropeptides 9
Sequence:
MNRSMIALCVVLMVSLVSAQVFDLDGQQLAGLEQNDARLMEQQVKRSPSAKWMRFGKRSPSAKWMRFGKRSPSAKWMRFGKRSGAEAVSEQDY
Protein: SLIT and NTRK-like family, member 1 (D3Z8D8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase S
- Receptor-type tyrosine-protein phosphatase delta
- Receptor-type tyrosine-protein phosphatase F
- Interleukin-1 receptor accessory protein-like 1
- Adhesion G protein-coupled receptor L3
- NT-3 growth factor receptor
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
Sequence:
MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKINGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKPPVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRRSHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYAKISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD
Protein: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) (Q5VV67)
Organism: Homo sapiens (Human)
Function: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:11340167}. Note=Colocalizes with NRF1. {ECO:0000250}.
Interaction partners:
- Nuclear respiratory factor 1
- Host cell factor 1
- Transcription factor A, mitochondrial
- Crooked neck-like protein 1
- Cell division cycle 5-like protein
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-processing-splicing factor 8
- Protein BUD31 homolog
- Pleiotropic regulator 1
Sequence:
MAARRGRRDGVAPPPSGGPGPDPGGGARGSGWGSRSQAPYGTLGAVSGGEQVLLHEEAGDSGFVSLSRLGPSLRDKDLEMEELMLQDETLLGTMQSYMDASLISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELLVSPREGSSLHKLLTLSRTPPERDLITPVDPLGPSTGSSRGSGVEMSLPDPSWDFSPPSFLETSSPKLPSWRPPRSRPRWGQSPPPQQRSDGEEEEEVASFSGQILAGELDNCVSSIPDFPMHLACPEEEDKATAAEMAVPAAGDESISSLSELVRAMHPYCLPNLTHLASLEDELQEQPDDLTLPEGCVVLEIVGQAATAGDDLEIPVVVRQVSPGPRPVLLDDSLETSSALQLLMPTLESETEAAVPKVTLCSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEPQNPPANAAPGSQRARKGRKKKSKEQPAACVEGYARRLRSSSRGQSTVGTEVTSQVDNLQKQPQEELQKESGPLQGKGKPRAWARAWAAALENSSPKNLERSAGQSSPAKEGPLDLYPKLADTIQTNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLASTSSELVEPLPAEPVLINPVLADSAAVDPAVVPISDNLPPVDAVPSGPAPVDLALVDPVPNDLTPVDPVLVKSRPTDPRRGAVSSALGGSAPQLLVESESLDPPKTIIPEVKEVVDSLKIESGTSATTHEARPRPLSLSEYRRRRQQRQAETEERSPQPPTGKWPSLPETPTGLADIPCLVIPPAPAKKTALQRSPETPLEICLVPVGPSPASPSPEPPVSKPVASSPTEQVPSQEMPLLARPSPPVQSVSPAVPTPPSMSAALPFPAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLVSGTPGAYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPASIGRAVPQPKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKHKVSALVQSPQMKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLPAVHPARLRKLSFLPTPRTQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPPPAPADSLAVGNSGGVDIPQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGVTEAKHPAAVRLQEGVHGPSRVHVGSGDHDYCVRSRTPPKKMPALVIPEVGSRWNVKRHQDITIKPVLSLGPAAPPPPCIAASREPLDHRTSSEQADPSAPCLAPSSLLSPEASPCRNDMNTRTPPEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSSGSNRTSEASSSSSSSSSSSRSRSRSLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPSPRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR
Protein: Cyclin N-terminal domain-containing protein (Q9BLB5)
Organism: Caenorhabditis elegans
Interaction partners:
- Cyclin-dependent kinase 1
- Cyclin-like domain-containing protein
- Cyclin-dependent kinase 2
- Separin homolog sep-1
- Serine/threonine-protein kinase plk-1
- separase
- PUM-HD domain-containing protein
- Cyclin-dependent kinase 4 homolog
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3
- Serine/threonine-protein kinase plk-2
Sequence:
MLRATTSIRKITKNLEKRSSVKNQHENGSSTPVNTEGLAVGPRTKLEEEFNCMAEDIYNYLVHHEKKYVLDDSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFDLSCPSSLVFLRYISKTLTENDVNPIDKETFYYVHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPKTAASMIRKQFGASKQDIYDAISLLAQVAYKNFRHQKLCAIREKYQSSKFGRVSYLMTDEILEKIHRMGRNLEASEAETSEME
Protein: Major histocompatibility complex, class II, DM beta (H0Y4B8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHTGAPEPILRDWSYTPLPGSNYSEGWHIS
Protein: Spindle pole body-associated protein cut12 (Cell untimely torn protein 12) (O59755)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for bipolar spindle formation. May act as a regulator of the p34cdc2/cyclin B kinase. Required for full activation of the plo1 kinase. However, in cut12.1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B. The cut12.s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:9531532}.
Interaction partners:
- GTP-binding protein 1
- M-phase inducer phosphatase
- Kinetochore protein nsk1
- Serine/threonine-protein kinase plo1
- Serine/threonine-protein phosphatase PP1-1
Sequence:
MSETLNTPPTYAWVLKAFSSKLAGTVTKPVTKMSSYIEDAESDAELPQDAKEDLRPTETLTPLKSKAAQNGILKTPGTLQIKKTVNFKDISKDAATWNRPTKNNFLFTRLDDENPLMGHEEFKSPLLQSTPKPNINNPDNENKSKHDEFDNRYNININESYKNETKSNQRLGEDVPSKKKYPHSMDAEISKFKWDSNNNNDWSSLMKDCFRDVVNNNRKMKEIIKDVMIDTSQAFPSESLDEPDYTINLDAPRSSSGKYWKQKFSMLDSAHSDLELELTSIRERLESLILEKQEEINFWKQRCRALETEKIHNHQGQQSKYKGKEFVGNRFSQMRELYTAKPSPITTKVVSRPSQSDVREPQEQVPSKNLHRGADMSHLAAQMLTHSSKKSHTTNLIPSEGIISSTPISAASKVRMNLMQSNQTPTPAPFSIAAKKSHLPSKLSFPQDGGSLSSATTLQQLPKARVTPNVLSSLSSNLGKTNPTSVYQSKANVTTSADVEKPQVKVATSSRVDYDLKSPNQRTANAKKRLEERRRRRKLKLQELQLNS
Protein: Pericentriolar material 1 (G3V7E6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATGGGPFEEVMHDQDLPNWSNDSVDDRLNNMEWGGQQKKANRSSEKNKKKFGVASDKRVTNDISPESSPGVGRRRTKVPHTFPHSRYMTQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLGENRKPFNFLPMQINTNKSKDATASLPKRETTTSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIEHLKEQEKSYMKFLQKILARDPQQEPMEETENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVTETTGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREISQSRNPSVSEHLPDEKVQLFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSFVPSTSLPRSGDKRSSTVALSAPVGFAPAVNGESNSLISSVPCPAASLVSQNESENEGHLNPAEKLQKLNEVQKRLNELRELVHYYEQTSDMMTDAVNENTKDEETEESEYDSEHEHSEPVTNIRNPQVASTWNEVNTNSNTQRGSNNREGRSINSSCEINNRSAANIRPLTTPLLDCRYNREGEQRLRVARGEDEEEEVEEEGVSGASLSSRRSSLVDEAPEDEEFEQKISRLMAAKEKLKQLQDLVAMVQDDDATQVLVPAASNLDDFYVAEEDTKQNSNNARENSNKVDTGVNEKTREKFYEAKLQQQQRELKQLQEERKKLIEIQEKIQAVQKACPDLQLSATSISSGPTKKYLPAITSTPTVNENETSTSKCDIEPEDSSVVDNELWSDMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLGTPQQSRTEKTMATWGGSTQCALDEDGDEDGYLSEGIVRTDEEEEEEQDASSNDNFPMYHPSMNQNSYNVKETKNRWKNHRPVSADGNYRPLAKTRQQNISMQRQENLRWVSELSYIEEKEQWQEQINQLKKQLDFSVNICQTLMQDQQTLSCLLQTLLTGPYSVLPSNVASPQVHLIMHQLNQCYTQLTWQQNNVQRLKQMLTELMRQQNQHPEKPRSKERGSSASHPSSPSLFCPFSFPTQPVNLLNLPGFTNFPSFAPGMNFSPLFPSNFGDFSQNVSTPTEQQQPLAQNPSGKTEYMAFPKPFESSSSLGAEKQRNQKQPEEETENTKTPWLYDQEGGVEKPFFKTGFAVSVEKATNSNRKRQPDTSRRGRQFDEESLESFSSMPDPIDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKTIGYESASVSSTCEPCKSRNRHSAQTEEPVQAKLFSRKNHEQLEKIIKYSRSAEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESDEKEGENIKSVNSGTWVASNSELTPSESLVTTDDETFEKNFERETHKITEQNDADNVSVMSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTETESNSNMRCTCRVIEDEDGAAATTTVSNAEETPIIENHSSPQPTSDVSAVPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSIAVKQRCKRKIEAAGVIQSYAKEAKRILEGDRGSPAGEIDDEDKDKDETETVKQTQTSEVYDAKGPKNVRSDVSDQEEDEESERCPVSINLSKAESQALTNYGSGEDENEDEEMEDFEESPVDVQTSLQANTETTEENEHDNQVLQHDLEKTQESTNVPSDQEGTSKNDQDSSPVKPCYLNILENEQHLNSATHKDSLTTTTDSSKQPDPMPLPLTASETLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTVCSEAELRKKMVEEEQKNHLAGEICEMQTEELAGNPQILKEPETVGAQSV
Protein: Troponin T (Q27371)
Organism: Caenorhabditis elegans
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.
Interaction partners:
- EF-hand domain-containing protein
- Troponin I 2
- Troponin I 1
- Tropomyosin isoforms a/b/d/f
- Troponin I 3
- Myosin, essential light chain
- Paramyosin
- Myosin regulatory light chain 2
- Myosin regulatory light chain 1
- Alpha-actinin, sarcomeric
Sequence:
MSDEEEVYSDEEVEEEEVEETEEAPAEAEEPEETTEEVVAPPEVKERRAPVQEEKPPAEMTEAEIAMLAAKKRHEEEEAAKLLDYEQRRVLEKEQIEQELRELKEKQEKRRAEREEDERQFAERRRQDDERRRKEEDERKAKADAEKIRKNEEKVRRQQMMAGAFNGRVEAGAGRNFTVASKGDQAAQFGNLAQAKGGKDVMSKEQMEDAKRNFLAAVCRVQDVSGLLPNDLKERIRGLHARIVKLEAEKYDLEKRRERQDYDMKELHERQRQAARNKALKKGLDPEEAASSVHPPKITTASKFDRQTDRRSYGDRRYLFENPEEEKQASLVRGTGRPPAEWGRKQNEELEQIRKNLEPPKYVEQVKVEGARAPVEPVPLFVPTDDFEPQQVTEDPNVGEEVVVE
Protein: Sperm acrosome membrane-associated protein 6 (E9Q8Q8)
Organism: Mus musculus (Mouse)
Function: Sperm protein required for fusion of sperm with the egg membrane during fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:32393636}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein F
- Sperm-egg fusion protein TMEM95
- Small nuclear ribonucleoprotein G
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm8
Sequence:
MTSQRSLSSPQTRRPSVMGLISLVGSIVLLFLLIFRASTWACLFCFTTYEERLRVCQLFVGREETKINLCRNELEGAFEDLKDMKINYDERSYLHDEFTQMTVSLQEKAARRREPFWLAFKDAAAKLKRTIEHLKKAPACIPPCGLQEVARLFHCSGCFSKLCDLPLDCPVQDMLVNRGDQALFSCIVAFELPESEITYSWKFVGGVRTKDVTYFRDMPGAHGYLARIRPVQPKHGGTFSCVILHDQRPLARLYFYLNVTGPPPPEDTELQVTFREVMNRTPAEPEMIQPWSPSLGELLTNPQALTLGNLFLLAATAALGSASVTLLVWLFFRWYLSGN
Protein: Kelch-like protein 21 (Q9UJP4)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19995937}. Note=Localizes to the spindle midzone and targets CUL3 to this region.
Interaction partners:
- Cullin-3
- Kelch-like protein 9
- Kelch-like protein 13
- Kelch-like protein 25
- Kelch-like protein 22
- E3 ubiquitin-protein ligase RBX1
- Kelch-like protein 41
- Kelch-like protein 7
- Kelch-like ECH-associated protein 1
- Kelch-like protein 42
Sequence:
MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH