wanglab/gogpt-training-data huggingface dataset:
Protein: Kinase suppressor of Ras 1 (mKSR1) (EC 2.7.11.1) (Protein Hb) (Q61097)
Organism: Mus musculus (Mouse)
Function: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:11741534, ECO:0000269|PubMed:12932319, ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:23250398}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Cell membrane {ECO:0000269|PubMed:11741534, ECO:0000269|PubMed:12932319, ECO:0000269|PubMed:23250398}; Peripheral membrane protein {ECO:0000269|PubMed:11741534, ECO:0000269|PubMed:12932319, ECO:0000269|PubMed:23250398}. Cell projection, ruffle membrane {ECO:0000269|PubMed:23250398}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IVT5}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305|PubMed:12932319}.
Interaction partners:
- Lymphocyte-specific protein 1
- Midkine
- RAF proto-oncogene serine/threonine-protein kinase
- Dual specificity mitogen-activated protein kinase kinase 1
- Serine/threonine-protein kinase PLK3
- BRCA1-associated protein
- MAP/microtubule affinity-regulating kinase 3
- Kinase suppressor of Ras 2
- Serine/threonine-protein kinase B-raf
- Dual specificity mitogen-activated protein kinase kinase 2
Sequence:
MDRAALRAAAMGEKKEGGGGGAAADGGAGAAVSRALQQCGQLQKLIDISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVKYICKQQQSKLSVTPSDRTAELNSYPRFSDWLYIFNVRPEVVQEIPQELTLDALLEMDEAKAKEMLRRWGASTEECSRLQQALTCLRKVTGLGGEHKMDSGWSSTDARDSSLGPPMDMLSSLGRAGASTQGPRSISVSALPASDSPVPGLSEGLSDSCIPLHTSGRLTPRALHSFITPPTTPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVTPMKFELPHGSPQLVRRDIGLSVTHRFSTKSWLSQVCNVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRITFLPLARLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSPGQRDSRFSFPDISACSQAAPLSSTADSTRLDDQPKTDVLGVHEAEAEEPEAGKSEAEDDEEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREERRENQLKLSHDWLCYLAPEIVREMIPGRDEDQLPFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFSLLMDMLERLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM
Protein: Transcription factor Ouib (A8JQX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE40275p
- Serendipity locus protein beta
- LD26135p
- Serendipity locus protein delta
Sequence:
MKEFCRTCGKTVVADECLQIFTPAGRKLLQCVRSITNCWLQNVQDLPNHICTDCQVLLSQVQKFRRRCAKIEKYFARRRRRMNLGEAPAAMEQLRVQQAAAPDPLGIDELMSASDIKIEPIQLQMEEDPQAPYPENQLEQALSYGNAPGEDILPLPEDYGEAQTEVATTTNEPAQRRSKNTAKIKSKKHTMRVGRKLIHVKVIDDKQPKRIVDRNGPSAKPCICEHCGRQFKDTSNLHVHLLRHTGTKPFECDQCHQKCYTLHLLRRHQLKHTEGPYACTFCGLEYSTNSSRVRHEREACKKGRAPQSKWEIIKKGERTFHCEVCDLWFLRAGNFTQHINSSSHIENERRKKRKSNPTAINS
Protein: Competence protein ComGF (A0A0H2US22)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MVQNSCWQSKSHKVKAFTLLESLLALIVISGGLLLFQAMSQLLISEVRYQQQSEQKEWLLFVDQLEVELDRSQFEKVEGNRLYMKQDGKDIAIGKSKSDDFRKTNARGRGYQPMVYGLKSVRITEDNQLVRFHFQFQKGLEREFIYRVEKEKS
Protein: [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial (PDK 1) (Pyruvate dehydrogenase kinase 1) (EC 2.7.11.2) (Protein kinase of PDH protein 1) (Pyruvate dehydrogenase complex kinase 1) (PDC kinase 1) ([Pyruvate dehydrogenase [lipoamide]] kinase 1) (P40530)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. Also involved in telomere maintenance.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:18180296}.
Interaction partners:
- Serine/threonine-protein kinase PKH1
- Serine/threonine-protein kinase PKH2
- 26S proteasome regulatory subunit 7 homolog
- [Pyruvate dehydrogenase
- Serine/threonine-protein kinase YPK2/YKR2
- Serine/threonine-protein kinase SCH9
- Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- 26S proteasome regulatory subunit 8 homolog
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase complex protein X component, mitochondrial
Sequence:
MWKIMRSWKCGGMRWAHRQRPSHELLSQLSFDQHYKIRSNIELLIQDYASKPIAPLNYEYFLQYRPPLTKKEEYMLTIKTINLLLSLTCKRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLDDHEDAIVVLAKGLQEIQSCYPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNKGDTNKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQRTPVLIHPPSQDITFTCIPPILEYIMTEVFKNAFEAQIALGKEHMPIEINLLKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQSADSESTDLPGEQINNVSGMGFGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTALLSKK
Protein: Glutaredoxin 3 (H2KZJ5)
Organism: Caenorhabditis elegans
Interaction partners:
- BolA family protein
- Anamorsin homolog
- Putative bolA-like protein K11H12.1
- Uncharacterized monothiol glutaredoxin F10D7.3
- Glutaredoxin-1
- Glutaredoxin domain-containing protein
- Glutaredoxin domain-containing protein
- Glutaredoxin domain-containing protein
- Small ribosomal subunit protein eS21
- NFU1 iron-sulfur cluster scaffold homolog
Sequence:
MPIQEIKSGEEVAAFIKEPSPAVLHFYASWAPSCEQVNQLLDDLLAEIALPLRAAFIDAEALPGISLNFKITAAPTLVFFSNGKEVDRIDGFVPKEIQSKVVLVASRSLSQSSSDASSTTSSTPSLTPQQEKEALNARLGALVNSQKVMVFMKGDPSAPRCGFSRTIVELLNSHKIKFGSFDIFSDEAVRQGLKEYSNWPTYPQLYFDGELIGGLDVVKEEFSDPQFIKQLPKVGENSEGGSLEDRLKKLVSSQRLMLFMKGDRETPKCGFSRTIVDLLNKARADYHTFDILEDEEVRQGLKKFSNWPTYPQLYLDGELVGGLDVVKEELLDTHFLRQIPRIRND
Protein: Dro3 protein (Q2UYH5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVQMIFLFAILALMTIVLMEANTVSARDCLSGTFGGPCWAWSGEKCRRLCIEERHVSGHCSGGMKCWCEGC
Protein: Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) (P32239)
Organism: Homo sapiens (Human)
Function: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Cholecystokinin
- Gastrin
- Inactive tyrosine-protein kinase 7
- Guanine nucleotide-binding protein G
- V-type proton ATPase 116 kDa subunit a 3
- Guanine nucleotide-binding protein G
- Gastrin-releasing peptide
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
Protein: Negative Effect on Gut development (O16292)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSTDAFYSTAFPTIPGTPNLLGYTAYSPQSIFNDSRPASSVNNTPSTSFNSSIHSRNRSIAMLHSISHILSNDDSLGSTTESSTPSTPEIHPSNAPAKKTIPLVLISDTDEECDKKSRKRRIRSKSSKKSRGIRKSRKHEASDYRKKIMLGTFEGRKIVLKLMK
Protein: Cathelicidin (Q2NNC4)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MKMKVQVRSLILLAVAVLQVRSQNQTETRYEDIILVALPQLLPGEEQAFRPILNQLQVKTLNTEDVDQSEVSVRLTFPMQETFCSKSPGQPGKPCPLKKNGKLMMCSMMVRHPILEASNNLNTDLSKTNCEYMEAEDAMQKIRTRRSQARKCSRGNGGKIGSIRCRGGGTRLGGGSLIGRLRVALLLGVAPFLLDLSQINVMEIAFA
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) (Q8R015)
Organism: Mus musculus (Mouse)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- SNARE-associated protein Snapin
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Dysbindin
- BLOC-2 complex member HPS3
- BLOC-2 complex member HPS6
- BLOC-2 complex member HPS5
Sequence:
MSGGGTETPVACDAAQGGKKRDSLGTPGAAHLIIKDLGEIHSRLLDHRPVTQGEIRYFVKEFEEKRGLRELRVLKNLENTIQETNECLLPKCRETMECGLGETLQRLQAANDSICRLQQREQERKKVINDYLTASEKRRLVQWEEFVSGQPQRRAEVDEEHRRAVERLREQYAAMEKDLAKFSTF
Protein: DENN domain containing 4C (X6R5W5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
GKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI
Protein: Mitochondrial carrier protein CoAc1 (Mitochondrial carrier family protein 2) (Mitochondrial coenzyme A transporter CoAc1) (ZmCoAc1) (K7VYZ9)
Organism: Zea mays (Maize)
Function: Required for the accumulation of coenzyme A in the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23590975}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSSSQESTFTSASAAAQVNASALDLLPVYAKELIAGGAAGAFAKTAVAPLERVKILLQTRTEGFQSLGILQSLRKLWQYEGIRGFYKGNGASVLRIVPYAALHYMTYEQYRCWILNNSASSIGTGPVVDLLAGSAAGGTAVLCTYPLDLARTKLAYQVSNVGQTGNALGNSGQQQTYNGIKDVFKTVYKEGGARSLYRGVGPTLIGILPYAGLKFYIYEDLKSQVPDDYKDSVILKLSCGALAGLFGQTLTYPLDVVRRQMQVQSKQSQNSSDGFRIRGTFQGLLLIIRCQGWRQLFAGLSLNYVKVVPSVAIGFTTYDMMKALLGVPPRERVHASGGNK
Protein: Bystin (O54825)
Organism: Mus musculus (Mouse)
Function: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17242206}. Nucleus, nucleolus {ECO:0000269|PubMed:17242206}. Note=Associated with 40S ribosomal subunits.
Interaction partners:
- BMS1 homolog, ribosome assembly protein
- RRP12-like protein
- KRR1 small subunit processome component homolog
- Periodic tryptophan protein 2 homolog
- Nucleolar complex protein 4 homolog
- Nucleolar protein 14
- Protein LTV1 homolog
- Pre-rRNA-processing protein TSR1 homolog
- RNA-binding protein NOB1
- WD repeat domain 36
Sequence:
MPKFKVTRGASNREKHAPLAEQILAGNAVRAGTREKRRGREVEEEEEYVGPRLSRRILQQARQQQEELETDHGAGDRSAPPRERATRLGPGLPQDGSDEEDEEWPTLEKAAKMAGVDHQAEVIVDPEDERAIEMFMNKNPPVRRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGKLPKAFKVIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADLATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDGGVTME
Protein: Dro3 protein (Q2UY34)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVQIKLLFALLAVMTIVLMEANTVSARDCLSGTFGGPCWAWSGEKCRRLCIEEGHVSGHCSGGMKCWCEGC
Protein: Hypothetical membrane protein (Q8NTB4)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Hypothetical membrane protein
- ABC-type transporter, permease components
- Peptidase S1 domain-containing protein
- ABC-type transporter, ATPase component
- ABC-type transporter, ATPase component
- DUF732 domain-containing protein
- Uncharacterized protein involved in propionate catabolism
- ABC-type transporter, permease components
- ABC-type Fe3+-siderophores transport systems, periplasmic components
- ABC-type transporter, periplasmic component
Sequence:
MNRFPSALLAASVAGAALAIPATSAHAAESICTFTGDVGWNVRDSFNSYLLGNIANGSAYKYKGGLDVRDGVQTDGNGKTPALTWPVDSVTSSKISTSGGAHWTGHNLYPGDDLAEVPNNFTLDLDFSNITVELSGSTGRLLVDYTSREYINTHTLGEFQTGEQAELATITFAKAPDLTSNSVNVTGDVALTADGVEVFGGFYTAGEELAPITLNLTADEGCGSTPEPEDPETPSASSSDVSSSSFGDTITQVLSIGSMVGMAGLLFTIVNYFIQSFAP
Protein: AT-hook motif nuclear-localized protein 13 (AT-hook protein 2) (Q940I0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
Interaction partners:
- ARM repeat superfamily protein
- Nucleic acid-binding, OB-fold-like protein
- Putative nucleobase-ascorbate transporter 10
- RNA cytidine acetyltransferase 2
- Protein HEAT-INDUCED TAS1 TARGET 3
- At5g12410
- Eukaryotic translation initiation factor 4C
- DExH-box ATP-dependent RNA helicase DExH13
- Protein EMBRYO DEFECTIVE 514
- High mobility group B protein 4
Sequence:
MDSREIHHQQQQQQQQQQQQQQQQQHLQQQQQPPPGMLMSHHNSYNRNPNAAAAVLMGHNTSTSQAMHQRLPFGGSMSPHQPQQHQYHHPQPQQQIDQKTLESLGFDGSPSSVAATQQHSMRFGIDHQQVKKKRGRPRKYAADGGGGGGGGSNIALGLAPTSPLPSASNSYGGGNEGGGGGDSAGANANSSDPPAKRNRGRPPGSGKKQLDALGGTGGVGFTPHVIEVKTGEDIATKILAFTNQGPRAICILSATGAVTNVMLRQANNSNPTGTVKYEGRFEIISLSGSFLNSESNGTVTKTGNLSVSLAGHEGRIVGGCVDGMLVAGSQVQVIVGSFVPDGRKQKQSAGRAQNTPEPASAPANMLSFGGVGGPGSPRSQGQQHSSESSEENESNSPLHRRSNNNNSNNHGIFGNSTPQPLHQIPMQMYQNLWPGNSPQ
Protein: Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] (P63261)
Organism: Homo sapiens (Human)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28493397}.
Interaction partners:
- Actin, cytoplasmic 1
- Cofilin-1
- Cofilin-2
- Profilin-1
- Myosin-14
- Profilin-4
- Vinculin
- Profilin-3
- Actin nucleation-promoting factor WASL
- Myosin-9
Sequence:
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Protein: Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450 L-2) (Cytochrome P450 isozyme 5) (P15129)
Organism: Rattus norvegicus (Rat)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MVLNFLSPSLSRLGLWASVVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALEIQKLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAADVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQLILRSKNGIHLYLKPLASRSGK
Protein: 23.6 kDa heat shock protein mitochondrial (Heat shock 22 kDa protein) (Heat shock protein 22) (Low molecular weight heat shock protein) (O64960)
Organism: Zea mays (Maize)
Interaction partners:
- Heat shock 70 kDa protein
- 17.0 kDa class II heat shock protein
- Heat shock protein 90-2
- Heat shock protein 90-2
- Heat shock protein 26
- Chaperone protein ClpB1
Sequence:
MASIVASRRAVPLVRALEKLIAASSAPGTGSALRPVAVAGGLRGYNTGAPLRRYEGAESEDDSVREYDGRHGGRDYAVPSLFSDIFRDPLSAPHSIGRLLNLVDDLAVAAPGRAVRRGWNAKEDEEALHLRVDMPGLGKEHVKVWAEQNSLVIKGEGEKEDSEDEAAPPPRYSGRIELAPEVYRMDKIKAEMKNGVLKVVVPKVKEQQRKDVFQVNVE
Protein: Ly6/PLAUR domain-containing protein 6 (Q86Y78)
Organism: Homo sapiens (Human)
Function: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
Subcellular location: Secreted {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19653121}. Cell membrane {ECO:0000269|PubMed:25680266}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTT2}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000250|UniProtKB:D3ZTT2}. Perikaryon {ECO:0000250|UniProtKB:D3ZTT2}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000250|UniProtKB:D3ZTT2}.
Interaction partners:
- Secreted Ly-6/uPAR-related protein 1
- Low-density lipoprotein receptor-related protein 6
- Ly-6/neurotoxin-like protein 1
- Frizzled-8
- Lymphocyte antigen 6H
Sequence:
MEPGPALAWLLLLSLLADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPRCMSVIVSCLWLWLGLML
Protein: Plastid developmental protein DAG (F4IDD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MARIIRRPLNLTAAVRFRLSPLSPFSGNSGSINSETTSWSELIRVPSLVEGCDYKHWLVLMKPPNGYPTRNHIVQSFVETLAMALGSEEEAKRSIYSVSTKYYYAFGCRIHEPLTYKIRSLPDVKWVLPDSFIVDGDNRYGVFFAGEPFVDGEVVPYDEKYHADWLRDQTDEDAKSGVVKKKHRRKRKKKLI
Protein: At2g28940 (Protein kinase superfamily protein) (O81064)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
- Probable quinone oxidoreductase
- Methionine aminopeptidase 1A
- Isoflavone reductase homolog P3
- Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial
- ADP-ribosylation factor
- Cysteine-rich repeat secretory protein 55
- Adenylate kinase 4
- Methylenetetrahydrofolate reductase 2
- 26S proteasome regulatory subunit 4 homolog B
Sequence:
MKCFHFTNGDKRTTTTIEEGVGGGDSVVSRASRLSWARSLSVASSTTSDPTRRSEFDSDWSFSPERLTFPKPLSQRWIGGLVPENDLKVFTFKELKIATKGFNRGLLIGEGGFGCVYRGVVDVSDSNGFDSKINVAVKQLNRQGLQGHKEWINEVNFLGVVNHPNLVKLVGYCADDDERGMQRLLVYELMCNKSLEDHLVGRVVSVSLPWMMRLKIAQDAAQGLAYLHEEMDFQLIFRDFKSSNILLDERFGAKLSDFGLARQGPPEGLGHVSTSVVGTVGYAAPEYVQTGKLTAKSDVWSFGVVLYELITGRRAVDRNRPRGEQKLLEWVKPYVSDSKKFHLIVDPRLEGQYYCMKSVQRVAALANKCLMKQPKSRPKMSEVVSLLGRIIDEEAENVPPPVADETEEIIKAELNGESEPELKKQGSSYRKKVLDLRDKMNLNKSLSKLDWRNWTPGLVRTW
Protein: Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) (Q9BQ52)
Organism: Homo sapiens (Human)
Function: Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21593607}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:24703694}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly mitochondrial.
Interaction partners:
- Zinc phosphodiesterase ELAC protein 1
- ATP-dependent RNA helicase SUPV3L1, mitochondrial
- Nuclease EXOG, mitochondrial
- tRNA methyltransferase 10 homolog C
- Endonuclease G, mitochondrial
- DNA cross-link repair 1A protein
- Cleavage and polyadenylation specificity factor subunit 3
- 2-5A-dependent ribonuclease
- CCA tRNA nucleotidyltransferase 1, mitochondrial
- Mitochondrial ribonuclease P catalytic subunit
Sequence:
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPERSSDSESNENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKADAPVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISPDTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERALASLGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLRTCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAVEKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFSEKVGVAFDHMKVCFGDFPTMPKLIPPLKALFAGDIEEMEERREKRELRQVRAALLSRELAGGLEDGEPQQKRAHTEEPQAKKVRAQ
Protein: tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (dADAT1) (tRNA-specific adenosine-37 deaminase) (Q9V3R6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Interaction partners:
Sequence:
MCDNKKPTVKEIAELCLKKFESLPKTGKPTANQWTILAGIVEFNRNTEACQLVSLGCGTKCIGESKLCPNGLILNDSHAEVLARRGFLRFLYQELKQDRIFHWNSTLSTYDMDEHVEFHFLSTQTPCGDACILEEEQPAARAKRQRLDEDSEMVYTGAKLISDLSDDPMLQTPGALRTKPGRGERTLSMSCSDKIARWNVIGVQGALLDVLISKPIYFSSLNFCCDDAQLESLERAIFKRFDCRTFKHTRFQPQRPQINIDPGIRFEFSQRSDWQPSPNGLIWSQVPEELRPYEISVNGKRQGVTKKKMKTSQAALAISKYKLFLTFLELVKFNPKLSEMFDQQLSDPERIAYASCKDLARDYQFAWREIKEKYFLQWTKKPHELLDFNPMSNK
Protein: V-type proton ATPase subunit G 3 (V-ATPase subunit G 3) (V-ATPase 13 kDa subunit 3) (Vacuolar proton pump subunit G 3) (Q8BMC1)
Organism: Mus musculus (Mouse)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Interaction partners:
- V-type proton ATPase subunit F
- V-type proton ATPase subunit D
- V-type proton ATPase subunit B, kidney isoform
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit H
- V-type proton ATPase subunit S1
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit e 1
- V-type proton ATPase 116 kDa subunit a 4
- V-type proton ATPase subunit C 2
Sequence:
MTSQSQGIQQLLQAEKRAKDKLDEAKKRKGKRLRQAKEEAVAETDQYRMQMEKDFRLKQAKIMGSQSHLSDEIEEQTLEKIKELNGSYNKCMESVIKQLLSMVCDMKPEVHVNYRATN