wanglab/gogpt-training-data huggingface dataset:
Protein: Structural maintenance of chromosomes protein 5 (DNA repair protein spr18) (SMC partner of rad18) (O13710)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}. Barrier septum {ECO:0000269|PubMed:16823372}. Chromosome {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Structural maintenance of chromosomes protein 6
- Non-structural maintenance of chromosome element 3
- E3 SUMO-protein ligase nse2
- Non-structural maintenance of chromosome element 4
- Non-structural maintenance of chromosomes element 1
- Non-structural maintenance of chromosome element 6
- Non-structural maintenance of chromosome element 5
- Structural maintenance of chromosomes protein 3
- SUMO-conjugating enzyme ubc9
- BRCT-containing protein 1
Sequence:
MDGLRPSKRRKSNPLYSDYALGSIVRIKLVNFVTYDYCELFPGPYLNLIIGPNGTGKSTIVSAICIGLGWPPKLLGRAKEAREFIKYGKNTATIEIEMKYRDDETVTITRQISQDKSSSFSINREACATSSITSLMDTFNVQLNNLCHFLPQDRVAEFAQLDPYSRLMETERAIDHEGLLPAHEKLIDLRKREREILQNKNQGQSTLNSLKDRQQALEKEVNIFKEREKIKSYIEMLGLAKMLVIYREKTNVFNQLRADKKKLKKDLKDLVEEFQPILDKGEELRSDLKLKDDTFNDYSSASMELNTSNLRARASFSNFMENEKKLYEKVNTNRTLLRNANLTLNEAQQSVKSLTERQGPRPSDNGVQDLQEKMQEVNAEKLQHENEKLESSHELGSIRTLKAQKLIDLDNIKRELSYYNDATKRKLDFMSSAPGWEDAYQTYQLLKEYESAFEAPAYGPIYMNLKCKEKGFAALIEGFFRTDTFRTFIMSNYNDYLKLMDLITSKTKYTPTIREFSSERKKKIEDFEPPCSREKLQSFGFDGYVIDFLEGPEVVLVALCHMLKIHQIPIAKRELPPASVNALNNFRLANGDPVLKTYLAGSSIHLVFRSAYGDREITRRTDPLPSRSIYFSENVEMDLVKRKEEQLNAQLSQLENLQNEERKLQEKVNEHESLLSRTNDILSTLRKERDEKLIPIHEWQQLQERIEHQTLLLRQREKVPEQFAAEIEKNEDIRKENFEALMNSVLKVKENSIKATNNFEKMLGSRLNVIEAKYKLEKHEMDANQVNARLTEVQDRLKDITDKLASAREDAMSLYGSVVDSLQTQSSDRQTAITELNEEFATSSEVDNKISIEETKLKFMNVNSYVMEQYDARKKEIEELESKMSDFDQSVEELQDEMNSIKEDWVSKLEENVQCISDRFSKGMSGMGYAGEVRLGKSDDYDKWYIDILVQFREEEGLQKLTGQRQSGGERSVSTIMYLLSLQGLAIAPFRIVDEINQGMDPRNERVVHRHIVNSVCDNAVSQYFLVTPKLLPDLTYHRNLKVLCICNGAWLPATFRTSLSTYFEKLKKSALISSS
Protein: Upstream transcription factor 2, c-fos interacting (M0QXT0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
VIQNPFSNGGSPAAEAVSGEARFAYFPASSVGDTTAVSVQTTDQSLQAGGQFYVMMTPQDVLQTGTQRTIAPRTHPYSPKIDGTRTPRDERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGAVSTPDPQCLRWSRPPTLACRKSNSHGARESSLGWRPVGGACPKAPGPLAPQSKGGILSKACDYIRELRQTNQRMQETFKEAERLQMDNELLRQQIEELKNENALLRAQLQQHNLEMVGEGTRQ
Protein: Caerin-1.1 (P86501)
Organism: Litoria rothii (Roth's tree frog) (Hyla rothii)
Function: Antibacterial peptide with wide spectrum of activity.
Subcellular location: Secreted {ECO:0000269|PubMed:16124032}.
Interaction partners:
Sequence:
GLLSVLGSVAKHVLPHVVPVIAEHL
Protein: Myosin heavy chain kinase D (MHCK-D) (EC 2.7.11.7) (Q54SF9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphorylates threonine (By similarity). Not critical for regulating the assembly and disassembly of myosin II filament.
Interaction partners:
Sequence:
MEDNSFLKLSKKIEKILEKNDYLKKKVEQLTKSVDNHEFKIQELLLLLRKNNIHPTTTTTTTTTTNNNSTCVGISNSPPLSPRTSTDSMTNSNNSSATSSTTPSPTQTSTITTTSQIDPNSLTNSNNSFIPINSPISQTTVNNNNNNNNNNNNNNNNNNNNNNNNNNNNLNNQTITSPLSTSSSNSNSNSNSSSPIVSPVSSPQLSGSGNRPRIQFLGNGRMPSTGNLFKKEDSSDSLLKYSKDSEHLYIVPTTPRPSKSPSMDFIASTSLINTVSSNNTDSTNNDNSSILNDQQNQQQNQQQQNQQQQQEEINFITTEDKLPNLPDSNCQWAIIWEYSANDDEWTKALIIVEIDAKPFAKGALRNAYQLKIRSNAMQCFNHFATPIHEKYMEGKKLNLSQIPKLNQNLSLDTLYVAKDSKTSVNFNRYFEDVKMQMVCKSYGERYNSNHPPKKIEFLSAWVIEIQGTTNYRVGNRNSSNNTLYGLELFMKGEFKKQNSNFGTVFTERNTPQSFSHFTYECTTHEMVVVDIQGVDDIYTDPQVHTKDGKGYGEGNLGQKGIEKFLISHKCSPICLQFGLPPIGLETGRNAHRVIRGTMLLPDLTPDLYEPEYPLIENQPSNPLNSELTSIVHLSGHDERVCSLLINQDKTKLYSASADGYVKIWNLTNNEDLSKIQMIDSFRAHRRSIEKMLLNEKYLFTASSDGTIKIWSLPTTTTTTTTSKQSSSSSSSSYECIGKLEDHTAEVNDMCIDIENNFLVSCSFDKQIKIYDLSTFKCIKSLNAHGKSIKSIYMSGKYLFSSSNDQSIKIWDLEMCMCVYGMNDAHDAPITSLRMFGNRLFSASKDGEIKDWNLSTFQPTTTLDQHNMAITDILVTSNGYLFVSSDDSTIRIIDISNQNEPIKIISSTKAHRSGVNSLATDGKRIFSGGCDNLIKVWNWKNK
Protein: Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) (Q13435)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular location: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}. Nucleus speckle {ECO:0000269|PubMed:16923959}.
Interaction partners:
- U2 small nuclear ribonucleoprotein A'
- Splicing factor 3A subunit 1
- Pre-mRNA-processing-splicing factor 8
- Splicing factor 3A subunit 2
- Small nuclear ribonucleoprotein G
- Splicing factor 3B subunit 5
- E3 ubiquitin-protein ligase RNF113A
- U4/U6 small nuclear ribonucleoprotein Prp3
- Splicing factor 3B subunit 4
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Sequence:
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Protein: Glycerol-3-phosphate acyltransferase RAM2 (EC 2.3.1.15) (Protein REQUIRED FOR ARBUSCULAR MYCORRHIZATION 2) (A0A0M4FCN7)
Organism: Petunia hybrida (Petunia)
Function: Involved in the production of cutin monomers (By similarity). Esterifies acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate, a step in cutin biosynthesis (By similarity). Required for colonization of the root by mycorrhizal fungi, and appropriate hyphopodia and arbuscule formation. Cutin monomers act as plant signals that promote colonization by arbuscular mycorrhizal fungi (By similarity). This signaling function has been recruited by pathogenic oomycetes to facilitate appressoria formation and their own invasion (By similarity).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDGTLLVGRSSFPYFALVAFEVGGIFRLLFLVLASPLAGLLYYFISESAGIRVLIFATFAGMKVSDIESVARAVLPKFYSSDLHPETWHVFSSCGKRCVLTANPRIMVEGFLKEYLGADMVIGTEISMYKGRATGFVNKPGILVGDNKAMALKKAFCSTSTPDIGLGDRKTDFPFMNLCKESYIVRPDPGVKPMSQDKLPKPIVFHDGRLVQKPSPLMALMIILWIPVGFLLACLRIAAGALLPMPLVYYAFWALGVRVKVKGNPPPPAKKSTDQTGVLFICSHRTLLDPIFLSTSLGRPIPAVTYSVSRLSEIISPIKTVRLSRDRVTDANMIKKMLEEGDLVICPEGTTCREPFLLRFSALFAELTDELVPVAMSNKMSMFHGTTARGWKGMDPFYFFMNPSPTYEVTFLNKLPYDLTCKAGKSSHDVANYIQRTIAATLSYECTNFTRKDKYKALAGNDGTVTTKPGLAAKKVMGC
Protein: Carnosine dipeptidase 2 (J3QR27)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERD
Protein: MADS-box transcription factor 22 (OsMADS22) (Q9XJ66)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor. May be required for spikelet (rice flower) development. Transcription factor that functions to support the MADS55 in its function as negative regulator of brassinosteroid signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MARERREIKRIESAAARQVTFSKRRRGLFKKAEELSVLCDADVALIVFSSTGKLSHFASSSMNEIIDKYNTHSNNLGKAEQPSLDLNLEHSKYAHLNEQLAEASLRLRQMRGEELEGLSIDELQQLEKNLEAGLHRVMLTKDQQFMEQISELQRKSSQLAEENMQLRNQVSQISPAEKQVVDTENFVTEGQSSESVMTALHSGSSQSQDNDDGSDVSLKLGLPCGAWK
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8I207)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIISNLGSMNITLFHLCFFGFLFVILNFTLDNSNFSNGGDILLNRNLSEEKAEDDYKKSSSCSSLASTTKRSPSTASTSTSLRSASTASTASTLRSASTASTASTASTASTASTASTASTASTASAASTTRSASAASTTRSASAASTTRSASAASTTRSASTASTARSASTASTASAASAASTTRSASAASTTRSASAASTTRSASAASTTRSASAASTASTASTGSTSTTQSPSTSTSTTQSPSTSTSTTQSPSTSTSTTQSPSTGSTSGSTTRLPSTGSTIRFPSTGSSRLEDYEKEGSNVDITEEEEKEAESVDDNNKEGNESDNIYCMLCSSNTRGFGCDCKDAANYILKNLDLYDEHEAKKHASDRTKTFSKELSKLFKKLRTKDPNMFNKNKIVFQDLSKKHTWDKYELHLPGLAHGKYNNERDVELNKKLIDLEDGFTDTQYIRKLYSLINENEKEKFDDIKRKILCYCASKNKSLHRTPEESEQAWKYVQKLIKLYYNDFDKHFEKVFLIWLALSEGFDVFEYKMLIAANRLLWRKLSDKVQEESKVMIQD
Protein: EF-hand domain-containing protein (Q581Q7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPLLYASRAKHTRFKSIVQRTRRLLCNGASGANGIRKLSRGCGIAVDSGGQSMEKAKFVEALEESGVSLDSEDIEAIVHVLDRSGDGVLDPTDFIAALRRNLTPLKLTWITRVWYTFTQSKDGSVYIDEVLSSYNAAGHPDVVQNIRSEQGVRSEFEAAFSTTTNPDGAITRQEFEQYCSGVAALCANDLEFLTLMRGVWPASVRTPLDEETMRTHREQNPCNMTFSSYQTAAEKGAVTDVRTTVAVVDDIILSSHRPVVIQSPLAVRQLSIALRRQDVQRNFFLSRETFLEVLRGHRLYLKDPESALTVLDTAGDGSVDYLLYMNLLLPPLPPARLMMLERLWELFPKDTCGTADVIELHKRFSAEDGEEQDAFLTAWDVRQALYRRFTFEEIVEWHTPLSAMFELDNDFETMLKKRWDFS
Protein: Retrotransposon hot spot (RHS) protein, putative retrotransposon hot spot protein 4 (RHS4), putative (Q8IFJ1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Zinc-finger protein ZPR1, putative
- Zinc-finger domain-containing protein
Sequence:
MNQNGGCVGDTRNILNGWLNGAYRPMKRQAGRKNENPSETGEGKSLEEKLYDSIYNAKWSYVMSGYDEDPLGMKVFDGKPQRIWTEAEVDITPDPANVDAEIEERPDGLEIFVLTSEKGWPYNRFALGHTERCNEKFKHVYIRREIMRVWYKVEKGLRACWVEKAEDSPIHIVIGTPGIGKSCGLGSFLLHSLLHFHEGMLDVVAYFVGKIAYLIYNKKPGEEGRVEEDRSTDSAVTFIKTIRKKRGHIIVDIGKSLLIPPDELCHLGWGVTVLTSPDTVHYEEWEKDMGSRHIIINCDDVRDIKAFVAWKNLSVALDKKVSNTAKQELRGGLKDEWETVKQRIAVAGPVPRAVYDAVGHGGRMEAVAKKIRGLDANDKNGCEDLFRSSMNWQTEEVSYQMVQIVRSRGNGVSGDSYRSKELSGHIRTLLLWAVLGITARKVAESQLMMRNRSAAFISFESHALFAVLNPRVLEMMAKNLRHLHPPEKLRGKQSILSSMTPQQLCLTGWEVLPAARQNPIERCEYMVLYTPATAYEPLVDGFFFVEGRFTMSPGRQAKKAPKPKTLVLLHVTKSGCHSTTATKLNAFTERIKGYFSDWNTFSGNMAWEMIYMNGVNGGVITNWQKCEANVDKVIPARKAKQLQTFWETIEQFQVTFGDEMNAHLMVDLQEAKKAQGRRAMKAKRR
Protein: RE11240p (Q6NR10)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVLNLLFITTVIKSTFGVVTTGLWLIPLMLAAITYYRYDAVDPESRPLDQLNLYPEYDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQLSKLDWAYKTEPSTKACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNVLRYFKKSEDNRNPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYDNRDINGAKQAGFMIAQGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHGKVYRIAARREVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLPVGENMQDHVGMGGLTFLVDKPVAIVQDRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDNGARVKKVLGLKESVYQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINANYFDDPLDAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKEDWLTNPEYKVKRQANRLRDPDPASSNIQGIITLPNNITQGDSSNISDWSNMESNFSNSSHINNINFNSNSNSSNIESSSNFTLNYANS
Protein: Uncharacterized protein YghW (P64574)
Organism: Escherichia coli (strain K12)
Interaction partners:
- UPF0174 protein YaaW
- Uncharacterized protein YibT
- Inner membrane protein YeeA
- Glycolate oxidase iron-sulfur subunit
Sequence:
MNNHFGKGLMAGLKATHADSAVNVTKFCADYKRGFVLGYSHRMYEKTGDRQLSAWEAGILTRRYGLDKEMVMDFFRENNSCSTLRFFMAGYRLEN
Protein: isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (A0A0A0MSX9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIP
Protein: PHD finger protein 21B isoform 3 (A0A0S2Z615)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQALGTITAVPVTGPQVSSLQRLAGQGAAVLPQVRPKTLIPDSLPVAPGRDRPPKQPPTFQKATVVSVKNPSPALPTANNTVSHVPAPGSQPQALAEPAALASPLSSAGVAYAIISTSPSNAAAMAPSTAVSVVSDSIKVQPLLISADNKVIIIQPQVQTQPESTAESRPPTEEPSQGAQATKKKKEDRPPTQENPEKIAFMVALGLVTTEHLEEIQSKRQERKRRSTANPAYSGLLETERKRLASNYLNNPLFLTARERDHPR
Protein: Osmotic avoidance abnormal protein 8 (Q09423)
Organism: Caenorhabditis elegans
Function: Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23.
Subcellular location: Secreted {ECO:0000305|PubMed:21253570}.
Interaction partners:
- Uncharacterized protein
- Notch ligand osm-11
- Putative polypeptide N-acetylgalactosaminyltransferase 11
- N-acetylgalactosaminide beta-1,3-galactosyltransferase
- Nematode cuticle collagen N-terminal domain-containing protein
- GDP-mannose 4,6 dehydratase 2
Sequence:
MPAKMLKWLLIHIFLIHSIFCQDAPAQMPFFANSDPMMSKLSQIQFADAPTLKGDKYPDVDAHRIIAPIISPIMEVFDQMKENQRARDQAEKIRKDREDHPLSTSRSLWEMFQRLQRPTTTTTEAPPLIERLFKPYIEPWQKQLDDFSKDMAGITLIPTTTTTPAPTTTTTPNFLEKSLSMFFPSLRRKPQSIPTLPPTTTPTPRLFDPEMFDRLFFKRDKRQATIAPAPKFDIFTVPPPPPLFQEWEKPILSLSNPFTLNPLMKMFTTPSPPQTLAPLPKIPEPNPYEIKKGLPEPQFKLQDPFYNPLFPSRKSKMFDFLAGGEAGRLLG
Protein: Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Q80XZ4)
Organism: Mus musculus (Mouse)
Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8N6P7}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Interleukin-10 receptor subunit beta
- Interleukin-22
- Interleukin 20 receptor beta
- Interleukin-24
- Interleukin-22b
- Tyrosine-protein kinase JAK1
- Interleukin-20
- Interleukin-19
- Interleukin-10 receptor subunit alpha
- Interleukin-10
Sequence:
MKTLLTILTVGSLAAHTTVDTSGLLQHVKFQSSNFENILTWDGGPASTSDTVYSVEYKKYGERKWLAKAGCQRITQKFCNLTMETRNHTEFYYAKVTAVSAGGPPVTKMTDRFSSLQHTTIKPPDVTCIPKVRSIQMLVHPTLTPVLSEDGHQLTLEEIFHDLFYRLELHVNHTYQMHLEGKQREYEFLGLTPDTEFLGSITILTPILSKESAPYVCRVKTLPDRTWAYSFSGAVLFSMGFLVGLLCYLGYKYITKPPVPPNSLNVQRVLTFQPLRFIQEHVLIPVLDLSGPSSLPQPIQYSQVVVSGPREPPGAVWRQSLSDLTYVGQSDVSILQPTNVPAQQTLSPPSYAPKAVPEVQPPSYAPQVASDAKALFYSPQQGMKTRPATYDPQDILDSCPASYAVCVEDSGKDSTPGILSTPKYLKTKGQLQEDTLVRSCLPGDLSLQKVTSLGEGETQRPKSLPSPLGFCTDRGPDLHTLRSEEPETPRYLKGALSLLSSVQIEGHPVSLPLHVHSVSCSPSDEGPSPWGLLDSLVCPKDEGPAVETEAMCPSAAASELEQSTELDSLFKGLALTVQWES
Protein: TLE family member 4, transcriptional corepressor (Q5JSY7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
APHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEKRDMGKLSETRLSEDEQCTLGLQRWFCRLWFMNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPL
Protein: Carboxypeptidase A1 (EC 3.4.17.1) (P00731)
Organism: Rattus norvegicus (Rat)
Function: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9UI42}.
Interaction partners:
- Chymotrypsin-like elastase family member 2A
- Chymotrypsin like elastase 3B
- Cationic trypsin-3
- Chymotrypsinogen B
- Bile salt-activated lipase
- Pancreatic triacylglycerol lipase
- Proteasome 20S subunit beta 10
- Carboxypeptidase B
- Carboxypeptidase A2
- Mast cell carboxypeptidase A
Sequence:
MKRLLILSLLLEAVCGNENFVGHQVLRISAADEAQVQKVKELEDLEHLQLDFWRDAARAGIPIDVRVPFPSIQSVKAFLEYHGISYEIMIEDVQLLLDEEKQQMSAFQARALSTDSFNYATYHTLDEIYEFMDLLVAEHPQLVSKIQIGNTFEGRPIHVLKFSTGGTNRPAIWIDTGIHSREWVTQASGVWFAKKITKDYGQDPTFTAVLDNMDIFLEIVTNPDGFAYTHKTNRMWRKTRSHTQGSLCVGVDPNRNWDAGFGMAGASSNPCSETYRGKFPNSEVEVKSIVDFVTSHGNIKAFISIHSYSQLLLYPYGYTSEPAPDQAELDQLAKSAVTALTSLHGTKFKYGSIIDTIYQASGSTIDWTYSQGIKYSFTFELRDTGLRGFLLPASQIIPTAEETWLALLTIMDHTVKHPY
Protein: Cell envelope integrity protein EipB (Q2YRJ0)
Organism: Brucella abortus (strain 2308)
Function: Functions in the periplasm to maintain cell envelope integrity.
Subcellular location: Periplasm {ECO:0000269|PubMed:30936371}.
Interaction partners:
- TIGR02302 family protein
- DUF6460 domain-containing protein
- DUF1150 family protein
- Lipoprotein
- RNA-binding region RNP-1
- DUF58 domain-containing protein
Sequence:
MRFVRIAAAASGATVFMWAGFAGAASAASAVRLVPHRAIYDLTLDRADEKSGISGLTGRMVYEFNGSACEGYTTNFRFVTRVDMDEQPQRVTDQQTTTFEDADGKDFRFVNKTFVDKELVKEVRGDAKLEDGKTVVKLSKPKENTLDLKGTQFPTRHMEELIGKAEAGQKFYQTTLFDASEDADRVVATTVVVGKQQAVPDDETKVMGKFSKDQVWPVTIAYFDDKEQQDGMPIYRINFKLYRNGITRDLTMDYGDFSMRGKLVKLDIYDTGKNKTGCSK
Protein: Ferritin (EC 1.16.3.1) (Q9TYS3)
Organism: Caenorhabditis elegans
Interaction partners:
- Ferritin
- Solute carrier family 40 member
- Solute carrier family 40 member
- NRAMP-like transporter smf-3
- NRAMP-like transporter smf-1
- Protein Asterix
- NRAMP-like transporter smf-2
Sequence:
MSLARQNYHSEVEAAVNKQINIELYASYVYLSMSFYFDRDDVALPNIAKFFKEQSDEEREHATELMRVQNLRGGRVVLQDIQKPENDEWGTALKAFEAALALEKFNNESLLKLHSTAGNHNDAHLTDFIEEKYLDEQVKSINEFARMVANLKRVGPGVGEYVFDKEHFSD
Protein: Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) (O14813)
Organism: Homo sapiens (Human)
Function: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Kinesin-like protein KIF21A
- Achaete-scute homolog 1
- Dopamine beta-hydroxylase
- Tubulin beta-3 chain
- Heart- and neural crest derivatives-expressed protein 2
- Tyrosine 3-monooxygenase
Sequence:
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF
Protein: Nucleoporin pom152 (O94385)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity).
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:16823372}. Nucleus membrane {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein. Note=Central core structure of the nuclear pore complex. {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 31 protein
- Nuclear envelope protein ndc1
- Nucleoporin nup184
- Probable nucleoporin C890.06
- Nucleoporin nup60
- Meiotically up-regulated gene 87 protein
- Nucleoporin npp106
- Lap-Emerin-Man domain protein 2
- Nucleoporin nup189
- Nucleoporin nup85
Sequence:
MVTRVASSERPRPLVPESIVDAPTQRLYAIGVFVALQAYKIYDLLKLETSSISDVPKSGFLVKWIIIDAIYLRLLPKFRIPWLSFQPAATLLQIAIFAAINLLLSSLSSLKWISIGSILLPYFKKKELSISEHKINPNNVIHNSSRILGQYTLQVLPEGTAKINPLHENYCLNSLRKDQYVDLAIQFNSTIPKYIQYSHVDLETKEETLVEVSGRSLRKLLSSSSKNPKEPRLQTIYLKTNKRGLYTLKHVVDKSKLDVRIFRSEAVVVSCPTATFASRQSGGRLRERCVGDTDNAELKVTGVAPLQVTYRNWDGKHFNTHIIDSTIPDDFHPPAVVLSSNPKDIVFYKGIDIQWARSSEIFVPINTLLKAPGQWIYAVTQVTDALGNSQQFPSNDQFLLRFAHGYTEADGESHSLPENVYSVFVHQRPDIQFRGCSIESPANLFPNKETSLSLYSSFSEYNSLEVGVDRYELGLDPQNITVPPLSHKTYQISPRSSANINVKKPGIYVLSSVSSQYCSGEVLEPNTCLVVTPPEAKVSVSFEEISDQCAGSIGARADLELEGTPPFTIAYRMTKDNEASRIQYVTTDRTRYQLNFTPKKAGKYRYIILGIQDANYGYRELSGSSFYKDQTVFPLADASFEERRNGDLSTVVKTSCIGDTMSLPVLLTGSAPWTLEYEIFRNNKREESHVVESKDPRYILEVPMLVHGSQYTITLVSVKDSNGCKRSLNTADTVIKVRRQRPTATFYSSDNTYTLKSVEGALMKIPLRLAGEKPWYVEYSHTSGLNKVSHHKEVLNDPNSYLTVRKSGTYTLLSVSDSSCPGTIQNVEQKYQVEWLPRPFLSIPSLESSVKGKTRYYEQNAVCAGDSSAFEVQLSGSGPFLLKHDKILVDEKSKTYPKQKSELSTVQNTVLVKADTAVPGVYHYEFTKLSDSLYSDSDAVTIVNNQSYQAVVLQRVNSLPKASFMNVEKLYTFCINTDVTQSNAQLIAIQLQGASPFSLVIGIKNELTGSVSKYTLNDIHESVYKFAFPQEQLTLGKHVVRLLQVRDANGCAASITKTQPAAKVSVVEMASLAPLGSRQYYCVGDRLSFALQGLPPFDVEYEFNGVTQHATSDSHILTRLIELPGVVAMKSISDHGSHCKSYINPPIEQIVHDIPTVRISNGKDVIENIHEGDQAEISFHFTGTPPFSFSYARRALGKKRPGKVLETHTVTGINEYEYKVLSSVEGVYTVLSVQDKYCRYPQDSTSSSNI
Protein: B-related factor 1 (Q802Z8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRCKTCGGTDIDVDQARGVAVCMGCGSVLEDNIIVSEVTFVESGGGGSSAVGQFVAGDASGNVPSLGGNFQTSVGRESRAATLQNAKRQINHLGHQLQMNQHCLDTAFNFYKMALSKHLTKGRKSTHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLVLARELCINAPAIDPCLYIPRFAQLLEFGEKSHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHEFRRTIKEVISVVKVCEATLRKRLYEFEDTPTSELTIEEFMKTDLEQECDPPSFAAGLRKQKLKQIEQELAKKVDDIEGEICGYQDEIEVELESCRPKARGIYASCSREDDVVSLASSSHLDGEDDELRAAASHLYGENEEQEQDGERVSLTKRPSLSLLLGALPTSASLGLSESITKMGEEKENDVEAEGGELDLSGIDEDEIDRYILNDKEVKVKTELWMIQNADYLKEQKEKEERIAKEKEEGTYKERKPRKSTRRREPINANTADEAIEKMLEQKRISTKINYDVLKDLNKSSPKSPTRQPEEASAGAKRTPAARQRKPQLTSPDIGKTVSSFGKRLQPLVRAQPSKKLALDQIGSSVPVATPAVSAQTAVVVESGPVAYEEHADEEEEDEEDEHCVSAMQLMGGTSDYGYELDDDDGF
Protein: Solute carrier family 22 member 7a (Zgc:162334 protein) (A4IG77)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- BSCL2 lipid droplet biogenesis-associated, seipin,-like.
- Si:ch211-207k7.1 protein
- Uncharacterized protein.
- Tau tubulin kinase 1a.
- non-specific serine/threonine protein kinase
Sequence:
MRFEDVLREIGGFNKFQFLVLYILWLPRVILPLHFLLHNFISGVPPHHCALPRLDGRFSASGAEKEELAQIVALGIPRNSDGSYSSCKMYTMPMDFDLNGDLSVLYGNRSNVSVPCQNGWVYDRSQFTSTTATEWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSFVSSAVFGIIEAFSSSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTFTGTIISLGWSVGNMLLALLAYLIRDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGKYSYTKKLDIENLKKITIAEDSNKNHSYLDLVRTPKLRKIVLCSGIFWFAVAFTYYGISFNITGFGLNIYLTQFIYGVIEVPAKVGTYLTLDRIGRRNGQAWSLIIAGALIGLNSVIPTEFAAVRTGIAVIGKGFSEAAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVILFEDIWHYGPPVVFSATAVFSGCVVFLLPETTNVQLPENILDVEEGRHTLSTEAERDVELNEMNSGPADLQEKGS