wanglab/gogpt-training-data huggingface dataset:
Protein: F-actin capping regulator BSP1 (Binding of synaptojanin polyphosphoinositide phosphatase domain protein 1) (Capping protein interaction motif-containing protein BSP1) (CPI motif-containing protein BSP1) (Q06604)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cortical patch protein involved in endocytosis. May serve as an adapter to link INP52 and INP53 to the cortical actin cytoskeleton.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:12606027, ECO:0000269|PubMed:38088874}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:38088874}. Cell membrane {ECO:0000269|PubMed:12606027}; Peripheral membrane protein {ECO:0000269|PubMed:12606027}. Note=Localizes to the actomyosin contractile ring (PubMed:38088874). Peripheral membrane protein in a PtdIns(4)P and PtdIns(4,5)P2 manner (PubMed:12606027). {ECO:0000269|PubMed:12606027, ECO:0000269|PubMed:38088874}.
Interaction partners:
- Actin cytoskeleton-regulatory complex protein SLA1
- Reduced viability upon starvation protein 167
- Protein YSC84
- LAS seventeen-binding protein 3
- Proline-rich protein LAS17
- Protein HUA2
- Polyphosphatidylinositol phosphatase INP52
- Polyphosphatidylinositol phosphatase INP53
- Protein GTS1
Sequence:
MTKYERDPELVNFLSKVEDLNSKRYSNIPSSKPAGEALSPVRSHNSGEYRRADMMTGKNVEGCDNLAYRSAYNYEMTFSPKKTHYSLSELNLERITPRPDLEGSASQKEKKFLISEEDYLLLQKLKASQTYNDSNADKNLPSFEKGPRMPSRGRPRPREKEIITIQYDFELPGRADIPSSSSSSSPPPLPTRRDHIKITDGNEEKPLLPTRPNKAEVTESPSSRSIKPDAVVPERVKPAPPVSRSTKPASFLSSLEDNKLTKAKSYNSEMETPKTTVKSSHIDYLDSIQLKPTTLSPTMKNKPKPTPPSPPAKRIPRSESFIKSMLNSNLTTTSKPSLPEKPQKLRNANLAAHKTKPSIPPKKVELNIVLPELRPVETSPTKQNFENSIDLPKLRSSNRNIKKEEEDSIPEAIKGIQNLKKTKQQKPAIPQKKSFLTNNSKNTTLKNGDDINKLNDEIEALSLRNNLKKRPPTAPQRKISLPEALRKVELMKKSKTEPVLESSNELSINAKLDAIIASRNLRASNTLPELSGVNTNIATSDKYTTSRDETVKETKPLVHPNKNRTRGPRRKLPTRV
Protein: Rho GTPase-activating protein 39 (Q9C0H5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell division control protein 42 homolog
- Protein FAM83H
- Maestro heat-like repeat-containing protein family member 1
- Connector enhancer of kinase suppressor of ras 2
- Ras-related C3 botulinum toxin substrate 1
- Roundabout homolog 1
- demerged
Sequence:
MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASAESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLEKDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQPSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAPNPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAEGEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVVRAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAACAQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
Protein: FUN14 domain-containing protein 1 (Q8IVP5)
Organism: Homo sapiens (Human)
Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:22267086, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:33978709}; Multi-pass membrane protein {ECO:0000269|PubMed:22267086}.
Interaction partners:
- Gamma-aminobutyric acid receptor-associated protein
- Microtubule-associated protein 1 light chain 3 beta
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- Serine/threonine-protein kinase ULK1
- Microtubule-associated protein 1 light chain 3 alpha
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Sequence:
MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS
Protein: Rab3 GTPase-activating protein catalytic subunit (Rab3 GTPase-activating protein 1) (Q93538)
Organism: Caenorhabditis elegans
Function: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Rab3 GTPase-activating protein regulatory subunit
- Ras-related protein Rab-18
- Rab proteins geranylgeranyltransferase component A 1
- Ectopic P granules protein 5
Sequence:
MAEIEENTVFEINDFTIVTDMEHFGAAFEGILQKYEFSSRRPCLSNDVKYRLIVTDTNMISIGENKLRIELLQPVPASSNPSNDVEFVEAPKDEIEEDAHVIPFTVAEEVANLKHGFEVTDSFLLKFGIRECIIISPNDSSGTFTDENQVNTVMGNIKTILHSSRCEVPVFCYIKDQSLDMISGYASDGNSTYNFSSVVLRNINRRHCSMTDLLYLFKEHLGASISAFHEEVRMSSRFTHVVPLKQSKYFRNHTVETFGLLATGPTSSLPFDILEIAATWRFFRENSLTENHSHSDFDINYSSYWNIKMKSTKSSLLGVLDEILGVYREDTRKAIRSDLNCALILGKHYTQKELPNAFQKLTINSASEVKIGKHAETEDSGTNGPMPPALMKSWVNFIFNEAESDNESLAHELNMLNAASMSENQLSDDELVNNVKLDTLFNYKNPKSANTFLAPYKCAKKSTVTWRLAIALANARVFMSDQPRAEPQLWVEFLLKLREKYEKMETVEKVYNGIDHLQCSFSQKMQMLQLCIDARQKRHRMLDSAHSANNSDEFFDANESFNAETILEPNNEGRLKLFGLNLVEIPDVPMYIPVTQDACPLTDEMIDARNEHLFSLDEEDRVHLQMELVKSDMQSFKAANAGAVFADFLRWHSPKDYDEKTNTISERMLISNNVWVRSWEAALPIPVANQARIFNDTKIAEEILEIFNNATLDQVREWMKPTVFAATLERLTEIESSYGVSEEKQKQRTKTAKILANATLNNTPMDYNEISKYCSQIEMIHNMKVHLMQLFENAREKMHPPYPSETDVQSAIKQLVNIAVHNLWDNSTDEEPTFVIKPQDPIGRAIAVIGKLDELTEQQLINGHRKEYIFNWKHSCPSTTTIPMTHRMYADLRSDKHSLYFSMANDCNFSNSSYL
Protein: GH11385p (Immune-regulated catalase, isoform A) (Immune-regulated catalase, isoform B (EC 1.11.1.-)) (Q9VEP8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGGIQYICLLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQKRLEDNLLGSDITVKNGSLSHAQLLDTLPSLASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECENSLKGNREGHYAFRRLLGSSHYRNGFYQMFPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGGKYDVPSCLNYVRSALAVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVGGISENPVHGSIGPTFSCIISEQFVHVLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQLPSARNQMVSCEDV
Protein: Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (P29327)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62753}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62753}.
Interaction partners:
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS2
Sequence:
MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQLRIAGGNDKQGFPMKQGVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDANMSVLALVVLKKGEKDIPGLTDTTIPRRLGPKRASKIRKLYNLSKEDDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIALKKKRQIASKEASADYAKLLVQRKKESKAKREEAKRRRSASIRESKSSVSSDKK
Protein: LexA repressor (EC 3.4.21.88) (D5ALN0)
Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Interaction partners:
- Protein RecA
- DNA polymerase IV
- DNA repair protein RecN
- Methyltransferase
- Crossover junction endodeoxyribonuclease RuvC
- Indole-3-glycerol phosphate synthase
- DNA mismatch repair protein MutL
- Anthranilate phosphoribosyltransferase
- Nucleotidyltransferase/DNA polymerase involved in DNA repair
- Anthranilate synthase component II
Sequence:
MLTHKQLELLDFIQKRMARDGVPPSFDEMKDALDLRSKSGIHRLITALEARGFIRRMAHRARALEIVKLPESMERAAEAERGLQTQPAFTPTLIAGSRTEPPRGALPVAAAALDIPMMGRIAAGVPIEAIAEVAHHVTVPGAMLSGRGEHYALEVKGDSMIQAGINDGDIVVIRSQPTAENGDIVVALVEDLEATLKRYYRRGGMIALEAANPAYETRLLREDQVKVQGRLVGLIRSY
Protein: Attractin (DPPT-L) (Mahogany homolog) (O75882)
Organism: Homo sapiens (Human)
Function: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:7539799}; Single-pass type I membrane protein {ECO:0000269|PubMed:7539799}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:7539799, ECO:0000269|PubMed:9736737}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:7539799}.
Interaction partners:
- E3 ubiquitin-protein ligase MGRN1
- Melanocortin receptor 4
- Agouti-signaling protein
- E3 ubiquitin ligase RNF157
- Melanocyte-stimulating hormone receptor
- Ankyrin repeat domain-containing protein 46
- Dipeptidyl peptidase 4
Sequence:
MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVECECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAHIVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNSTMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDCHWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYDNAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSTCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEKCENLTTGKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLRGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI
Protein: Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) (A6H5Y3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99707}.
Interaction partners:
- Methylenetetrahydrofolate reductase
- Methionine synthase reductase
- Adenosylhomocysteinase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Cystathionine beta-synthase
- Cystathionine gamma-lyase
- Dihydrofolate reductase
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- S-adenosylmethionine synthase isoform type-2
Sequence:
MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQTHGTGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQDDIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFIAPLHSGVCDYLGLFAVACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRLTESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD
Protein: Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 1) (PFL-activating enzyme 1) (P0A9N4)
Organism: Escherichia coli (strain K12)
Function: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
Subcellular location: Cytoplasm.
Interaction partners:
- Formate acetyltransferase 1
- PFL-like enzyme TdcE
- Probable dehydratase PflD
- Autonomous glycyl radical cofactor
- Probable dehydratase YbiW
- Bifunctional aldehyde-alcohol dehydrogenase AdhE
- Formate channel FocA
Sequence:
MSVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCLDTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGVKPPKKETMERVKGILEQYGHKVMF
Protein: Primary component of eisosomes (Eurofung) (C8V645)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Multifunctional tryptophan biosynthesis protein
- Prephenate dehydrogenase [NADP
- histidinol-phosphate transaminase
- Chorismate mutase
- Chorismate synthase
- Tryptophan synthase
- tryptophan synthase
Sequence:
MNRTLSGRRRSSVNTGRHRFSIGTFRGLQHPQLSKKMNRVIKSENSAIAAHESAARQRMSIAAQISEWGETTEDEAISDISDKLGVLMAEMGEQEDVYAQHLEDYRSVLKHIRDTESSVQPTRDQRAKIADDIQRLKLKEPNSHKIETMEQELVRAEAQNLVAEAQLTNVTRQRFKEAYSVHLAAVIERGEKQALLARHARRLLNCLDDTSVIPGDEPKPYERGNDAKQIVEDAERELQSWETDYEHVETKAEHGAAAVPMSTSLPSSHEERGQRASQSQATESLEEQQEEYTQADATSVSDTYSRISANDAASPTRIHSISAPRMYAGAFETAPVVNRESVRKENERIGGEVKLKTLAPHDTQGIMSPGSDVDFPIRTKQSELGSPLDSQVQRVAVPI
Protein: Alpha-glucosidase (EC 3.2.1.20) (Q4J9M3)
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Interaction partners:
- Alpha-amylase
- Aconitate hydratase
- Beta-galactosidase
- Signal recognition particle receptor FtsY
- Amine oxidase
- Large ribosomal subunit protein uL11
- Glutamate dehydrogenase
- Universally conserved protein
- Conserved putative ATP binding protein
- Large ribosomal subunit protein uL2
Sequence:
MEIKAERKGKVVRVLINNPNPVIKFNFKADQSEMIPSDIEVTKDTTSHSINVLLPLNTKTHVLGLGEKAFELDRRRTRVTMWNTDSYGYTWYSDPLYVSIPFFILVDSSIKGYFFNSPSKLVFDMGLERYDKIIVKIPEESVEFFVFEGDSVQEVIEHYVELTGKPFELPEWALGYQISRYSYYPQETVEEVVRRHLEEDIPLSAIYLDIDYMEKYRLFTWDKAKFPSPKELIEKLHSLGVKVVTIVDPCVRLDQNYHVFKDGLGNYVENEDGTIYADILWPGLSVFPDFLNSKTREWWRNLVEKWVKENNIDGIWLDMNEPSPLNKKPFNPRAIHRLDDNSQVYHESVHNLYSLFQAMATKPSVDFVLSRAGYSGIQRYAAIWTGDNTTSWSDLTLQLALTLGLSISGVPYVGCDLGGFIGRTTDYLLLYRYFQIALFFPIFRNHKDKGGSDQEIYSIPDYWKEKIKRVIKMRYQFLPYLNALARESSKTGHPIIRPLAYHYFRDENAFKINDQYMVGEYLLYAPQINKEGKRLIYLPEGKWLNWWTDEEYEGKNWIESDHDFPLFLRYNSVVPYGNGLITLNVYGNSGKIELGDGTQILHENGNVKISPGVNKSKFEVMRRPNKG
Protein: Molybdopterin synthase sulfur carrier subunit (MOCO1-A) (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Molybdopterin-synthase small subunit) (Sulfur carrier protein MOCS2A) (O96033)
Organism: Homo sapiens (Human)
Function: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Subcellular location: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03051, ECO:0000269|PubMed:15073332}.
Interaction partners:
Sequence:
MVPLCQVEVLYFAKSAEITGVRSETISVPQEIKALQLWKEIETRHPGLADVRNQIIFAVRQEYVELGDQLLVLQPGDEIAVIPPISGG
Protein: Urease accessory protein UreG, putative (AFU_orthologue AFUA_2G12900) (Q5BGU8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Large ribosomal subunit protein uL23m
- Mitochondrial ribosomal protein, putative
- 50S ribosomal protein YmL27
- 50S ribosomal protein L36, putative
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein bL28m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL38
- Large ribosomal subunit protein mL46
Sequence:
MAHSHSHSHSHDNIADHGHSHEILDGPGSYLNREQPLIEDRDWSDRAFTIGIGGPVGSGKTALMLALCRALRDEYNIAAVTNDIFTREDAEFLTRNKALSPDRIRAIETGGCPHAAVREDISANLLALQNLHRQFQTDLLLIESGGDNLAANYSRELADFIIYVIDVAGGDKVPRKGGPGITGSDLLVVNKIDLAEAVGADISVMERDAAKMREGGPTVFAVVKKDQGVDHIVNLILSAWKASGAYELSLQRWKNGAPRGSGSVEP
Protein: Serine/threonine-protein kinase PknI (EC 2.7.11.1) (P9WI69)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Plays an important role in slowing down the growth of mycobacteria within the infected host.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16256441}. Cell membrane {ECO:0000269|PubMed:16256441}; Single-pass membrane protein {ECO:0000269|PubMed:16256441}. Note=More abundant in the cytosol than in the cell membrane. {ECO:0000269|PubMed:16256441}.
Interaction partners:
- Serine/threonine protein phosphatase PstP
- Uncharacterized protein Rv2915c
- Signal recognition particle protein
- Uncharacterized HTH-type transcriptional regulator Rv2912c
- Glycogen accumulation regulator GarA
Sequence:
MALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLSRALATAPADRFGSCREFADAMNEQAGVAIADQSSGGVDASEVTAAAGEEAYVVDYPAYGWPEAVDCKEPSARAPAPAAPTPQRRGSMLQSAAGVLARRLDNFSTATKAPASPTRRRPRRILVGAVAVLLLAGLFAVGIVIGRKTNTTATEVARPPTSGSAVPSAPTTTVAVTAPVPLDGTYRIEIQRSKQTYDYTPTPQPPDVNTWWAFRTSCTPTECLAAATMLDDNDHTQAKTPPVRPFLMQFGEGQWKSRPETVQFPCVGPNGSPSTQATTQLLALRPQPQGDLVGEMVVTVHSNECGQQGAVIRIPAVASRSGDLPPAVTVPDPATIPDTPDTTSTATLTPPTTTAPGPGR
Protein: Protein GIR2 (DRG family-regulatory protein 2) (Genetically interacts with ribosomal genes protein 2) (Q03768)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells.
Interaction partners:
- Ribosome-interacting GTPase 2
- Ribosome-interacting GTPase 1
- Serine/threonine-protein kinase ISR1
- Translation machinery-associated protein 46
- eIF-2-alpha kinase activator GCN1
- Protein IMPACT homolog
- Protein GCN20
- RQC trigger complex helicase SLH1
- Pre-rRNA-processing protein ESF1
- Translation machinery-associated protein 22
Sequence:
MDYKEEQKQELEVLESIYPDELRIINDEYPKIKFEVAIKLELDTGDSTSVLTKEHTIIAEFKLPENYPDEPCLISLEAQEVALNDNEEDNEEDEDEVEYDDHGNKVLKKFENLPDLISFKGYLPELTVQLESQIETDMLLGMQMCFALISSIKERCEQWYSEQLNKLEKQYELEAQEREKKEQAKFHGTKVTRESYLEWRSKFRQELKLDERDQVRRMKAHHGKLTGKQMFEQGVVGTGDEYMEEDDASVDDVAKGLAKTEIANQ
Protein: Transcription factor (bHLH transcription factor) (Basic helix-loop-helix protein) (Q6ZBI4)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369104}.
Interaction partners:
- Protein TIFY 3
- Protein TIFY 6a
- Protein TIFY 6b
- Protein TIFY
- Protein TIFY 9
- Transcription factor MYC2
- Os10g0506950 protein
- Protein TIFY 8
- Transcription factor
- Transcription factor
Sequence:
MDELVLSPSSFSATACFPTLDFEFCEVPDQWLLGLGHDELDKDAAASALAAAAASQSASNDDVPRNPPATTTTTKRRGRKPGPRSGGGGAPPIGHVEAERQRREKLNRRFCELRAAVPTVSRMDKASLLADAVDYIAELRRRVERLEAEARRAPLAPSAAAAAAWAAGLGAGAIGRDDLVVRMIGRDAAILRLTTAAAAARHAPARMMCAVRALNLAVQHASVARVGGATVQDVMVDDVPAALQDEARLRAALLHTLQLADTT
Protein: Transcriptional coactivator HFI1/ADA1 (Q12060)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. HFI1/ADA1 and SPT20/ADA5 may recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA complex subunit SGF73
- SAGA complex/transcription factor TFIID complex subunit TAF9
- SAGA complex/transcription factor TFIID complex subunit TAF10
- SAGA complex/transcription factor TFIID complex subunit TAF12
- Ubiquitin carboxyl-terminal hydrolase 8
- SAGA complex subunit SPT3
- Histone acetyltransferase GCN5
- SAGA complex subunit SPT20
- SAGA complex subunit NGG1
- SAGA complex subunit SPT7
Sequence:
MSAIQSPAPKPLQPTYPAASPASTNAYMKPGLIGSPAVSNHTEPNNGNNETAEPQGPNQRIDLGAMIEELTSLLGKESWTKYAQIISLFILGKLSRKELSNELELVFSPSAASLEKSNTNHHHSLVRLHNQLLLGIFANSLRENPLGRNGNESSWGFGNGSNNPNNKLKRINKHNSQIEVYKKIVMSLPLNDRNRLKMITKEAGKRGFIFCSVFQARLNNIPKIPIVTNPESLKRVKSNNLKTPLEWSQDIMNGFNVPLASESHSLPDTDSFYLRMVGIAREHGLVGTVDARCVELISLALDQYLKNIIEFTIDTVRYRRKKYSDYYDLNESGLYKSVSEMAADKRDAKIKQLDDDKNEDECADEAKSINNGNNSSKDDIGDISMSSITKAGEAVNEELHENRTISLTNEDIYDSLSIFPNLVEPSGSYYALTNLGLVNDDELVDMKSNIDDLPDFLNEKPTFTPLDERNVGTRHELNWLIKGILTED