wanglab/gogpt-training-data huggingface dataset:
Protein: Teashirt homolog 2 (SDCCAG33-like protein) (Zinc finger protein 218) (Q68FE9)
Organism: Mus musculus (Mouse)
Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPRRKQQAPKRAAGYAQEEVLKEEEEIKEEEEEEEDSGSVAQHQSSNDTGTDEELETGPEQKGYFSCQNSPGSHLSNQDAENESLLSDASDQVSDVKSVCGRDVSDKKANTHPKLPSEPHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNSSGKNDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKLCGSVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSLADSFSSQKSANLQLPSNSRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSETPNSESLAPKPSSNSPSECTASTTELKKESKKEKGEGIEDEQGVKSEDYEDSLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPMAMGSQILQIRPNLANKLRPIAPKWKGMPLGPVPTSLALYTQVKKETEDKDEVVKQCGKESPHEEATSFSQPEGESFSKIEPPSESRKAEPCPLKEEEKPQKEKPEPLEPVSSLTNGCAPANHTPALPSINPLSALQSVLNNHLGKATEPLRSPSCSSPNSSTSPVFHKSSLHVVDKPVISPTSTRPAASVARHYLFENTDQPIDLTKSKSKRAESSQAQSCTSPPQKHALCDIADMVKVLPKATTPKPAASSRVPPMKLEIDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRMAADQQSKVEQEISRVSSAQRSPETIAGEEDTDSKFKCKLCRRTFVSKHAVKLHLSKTHSKSPEHHSQFVADVDEE
Protein: Pentalenolactone F synthase (EC 1.14.11.36) (Neopentalenolactone F synthase) (EC 1.14.11.-) (Neopentalenolactone biosynthesis protein D) (Q82IY7)
Organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function: Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent oxidation of pentalenolactone D to pentalenolactone F. Also able to catalyze the oxidation of pentalenolactone D to pentalenolactone E. In presence of neopentalenolactone D, mediates production of PL308 and possibly neopentalenolactone E.
Interaction partners:
Sequence:
MSRAMDITRIPGSAIGAVVAGADFSGTIDDTQVEEIWQALDQHLVLVFRGHKDPSNDDLLMFARRFGHVPKTGLTTGASPDHNEILLISNILDENGQKIGVGNAEWMDWHTDYSFRPRVSRIGFLAAVELPPSGGGQTLFTDMYTAYESLPDDLRQRLHSYRARHSLRSGYEDVIEEEYQGEVSIEGPTAKPFVAPEDGTATVHQLIARNPRTGRRAVYANPLNTKRILELDVTSSKEVLQQLFAKPGEPELTYAHEWLPGDIVMWDQLGTVHAKRAFDPTERRLLRKVVTIFDDPAEPWHPEDAA
Protein: Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] (Q9GL10)
Organism: Ovis aries (Sheep)
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Interaction partners:
- Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein
- CRC domain-containing protein
- Spermatid nuclear transition protein 1
- Shelterin complex subunit TPP1/Est3 domain-containing protein
- Uncharacterized protein
- Protein boule-like
- Zonadhesin
Sequence:
MLPTAVLLVLAVSVVARDNTTCDGPCGVRFRQNRQGGVRIIGGQDAAHGAWPWMVSLQIFTYHNNRRYHVCGGSLLNSQWLLTAAHCFRIKKKVTDWRLIFGAKEVEWGTNKPVKPPLQERYVEKIIIHEKYSASSEANDIALMKITPPVTCGHFIGPGCLPQFRAGPPRVPQTCWVAGWGFLQENARRTSPMLQEARVDLIDLGLCNSTRWYNGRIRSTNVCAGYPEGKIDTCQGDSGGPLMCKDSAENSYVVVGITSWGVGCARAKRPGVYTSTWSYLNWIASKIGSTAVHMIQLPTASPASTPGAQASSGSVQPSVRPPWFFQQIT
Protein: UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation 13 homolog) (Q9D8C3)
Organism: Mus musculus (Mouse)
Function: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.
Subcellular location: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NP73}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NP73}. Note=Recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14. {ECO:0000250|UniProtKB:Q9NP73}.
Interaction partners:
- UDP-N-acetylglucosamine transferase subunit ALG14
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- UDP-N-acetylglucosamine transferase subunit ALG13
- GDP-Man:Man
- Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dol-P-Man:Man
- Dolichol-phosphate mannosyltransferase subunit 1
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Sequence:
MKRAFVTVGTTSFDELVARVVANDCVQILESLGYNHLVLQVGRGTVVPKPFRTESFTLDVYRYKDSLKEDLQQADLVISHAGAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCTCRVLSCPAPVSLLLVLLGSAKILQQLPSATLSCFGYLPTQAPVLVATAYSYLHSVFSSFPPLSTFLIIPCTMQKGWKKYCGQKSLNEASMDEYLGSLGLFRKVVAKDASCLFRAISEQLFHSQIHHLQIRRACVSYMKENQQAFESYVEGSFEKYLERLGDPKESAGQLELKALSLIYNRDFIIYRYPGKPPTQVTDNGFEDKIILCYSNNGHYDSVYSKEFQSTAGICQAILYELLYKDVFVVDEETLKTAVDLFRSGSRRNKHHALTASVEGSSDQKSSTEDRTEEAAACSSAASTPEGNKQGTERQKVPESPSKMLFPYKVLKALDPEIYRNVEFDAWLDSRKELQKSECVEYGGRYYFLGDKCQVCMESGGKYYNAHIQEIDNDKSSVVVFIEEFAERHSIPLAHVRPVNQVALLPSWNAIPIRNGRGYPTITGGYFPEIVMTDMNMKQRKKMFKKFRGKEIYMTMAYSRGDPLVPSRIQHSMHYGHDPLLYYSQTAGHILSSQHFYPQHSSQRQGRGYGMPRDSSHLISKQNLPNPKVGFCSGSGRKCCQSYDNVSYRSRSFRRSHRQMHCMNKGCQYGFAPENGVEETVTFYALEEGNETAYSTLPNNGGPTTMVPATSGYCVARQGYNSCKPPLNSGDSNDHCDNGGYHGDYLYSSEQGYETSSVYTTTVSTANLSLQDSGPSSVPQDTVTSYNYPQKVLENSAAIAVSWASHVPVPVIPNCAGDNEALRTSDISSQNAIQPGFVPPPAQGSPAYLEPSAAGAAGAAAAAAAAAAPVATPVAAPLPLPPPLPPPPPATLEAGDASGFPLPPPPPPPPPPPPPYSYDPSGSDLPQDTKVLQYYFNLGLQCYHHNYWHPMVYMPHVQQQLQPQPQPQPQPQPQPQPQPQPQPQQPQQQQPPPQQQQQQQEQVHGESYPDCTEQPLVDQSAPQVYSDVVREDGTQADVSTNDTFPIADAVPLPHGAVYYPVMTDPYGSPLLGFDSYVPVASDYSSIAMWHPVNAACGASAQIHGAMNPGPIGYMLLPNSPHYTPQN
Protein: Axoneme-associated protein mst101(3) (O01395)
Organism: Drosophila hydei (Fruit fly)
Function: Possible structural role in the sperm tail.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MLLSRFTSVFPRNVIVRGVSTLTSHVDRNYLVRSSFDKCQRFPFSDSKQEAEDVKKKCEEAAAKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEQEAAQKKKCAELAKKEKEAAEKKKCAEAAKKEKEAAERKKCEEAAFKQKCEEAAKKKKEAKKAAELQQKCAALAKKEKEAEMMKKCEEAAKKKAAEEAAKKKAEEVAAKKKADEAAAKKKCAEAKKKAEEAALKKMCEEAALKKMCEEAALQKKCAEAAKNAKKTDSET
Protein: Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) (Q9H0S4)
Organism: Homo sapiens (Human)
Function: Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing. Involved in apoptosis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.
Interaction partners:
- Something about silencing protein 10
- ESF1 homolog
- Neuroguidin
- WD repeat-containing protein 46
- Ribosome biogenesis protein BOP1
- KRR1 small subunit processome component homolog
- Protein RRP5 homolog
- Probable ATP-dependent RNA helicase DDX52
- Ribosome biogenesis protein WDR12
- Probable ATP-dependent RNA helicase DHX37
Sequence:
MAAPEEHDSPTEASQPIVEEEETKTFKDLGVTDVLCEACDQLGWTKPTKIQIEAIPLALQGRDIIGLAETGSGKTGAFALPILNALLETPQRLFALVLTPTRELAFQISEQFEALGSSIGVQSAVIVGGIDSMSQSLALAKKPHIIIATPGRLIDHLENTKGFNLRALKYLVMDEADRILNMDFETEVDKILKVIPRDRKTFLFSATMTKKVQKLQRAALKNPVKCAVSSKYQTVEKLQQYYIFIPSKFKDTYLVYILNELAGNSFMIFCSTCNNTQRTALLLRNLGFTAIPLHGQMSQSKRLGSLNKFKAKARSILLATDVASRGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRSGKAITFVTQYDVELFQRIEHLIGKKLPGFPTQDDEVMMLTERVAEAQRFARMELREHGEKKKRSREDAGDNDDTEGAIGVRNKVAGGKMKKRKGR
Protein: Chibby, isoform C (A0A0B4KHL3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPLFNKKFESKPIPVRQGRCNIGHPVATEDLDDFRQISLTLGNKELRFADGIWMHSTRKGDVDDMLRLNKKFRALEEENNMCNLKIEVMLDLLAEHATELSELKPKEK
Protein: tRNA/rRNA methyltransferase SpoU type domain-containing protein (Q381K3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ATP-dependent DEAD/H RNA helicase, putative
- rRNA biogenesis protein, putative
Sequence:
MEAKVEDVVVALVRCFCKGENEPHPSKAFGVAKELAMAMCGRERRLQFLRILALLESEKEMCTDAHIYCSGALILCDASGGGGCGTEETTKWEVEMVSILTAHPPYPKSVLAAVFYSIVQVTLSGCSIAILVAAGDSLRGVDTNLTVPKECAIELLAQFATALVTLNERCKRGPRGMNDDEVDEAKIRSEEERGITIRSMVIDYALNAIPYMREESAQGSYLCRRVLIPLLSLGDKALLEDGHSRICSLLTCNAGSQIDTVVLIAALFECLFSCVDGDRQRDYRCSTNLWDTIHAAIYGACTGSGSVENRVNMQSRAEYLLKRIVAMTRDQELREKWDASRIYHPLFVWVPTVSNNLWEMLFLILEVTNDYGMHIIQPILPKLDSLVEKVTADASVWADFGETGDEILLLQLKGGIHPLWVTLLFLKMLVHPNVAFRKIGLMRLWSLSAPLLKLFPRKFLFTSVLEVSLDTRLCAEVDRASHLTSFFGPKGFEGREVSPLVGTAGPLVDQLEQFYALLFCDVVQGAVERKEAMRRMLHCVVEKPSVHGATMILRILHGVVTTLALEIDDVSRCATVEMITDDVVLTEFMLVLRDAAQEKVPFWIDVRLSAIAFHVLLQFARMDPKTVRKSSNFWKLLCMCGPLGTSAGSSFMTVDTIAHVGVAGTCISPYYLNEHLLSVAQEAGVGGSNYRFVRDLLQVDNVLDKIRNFIRTKGSDEVQGKQLMFLLGALDSMGGEDRQVLADVARELAEMVLSFGRRPYSEAEDIFVALVAFVEFHHSVGSQPCTRYFPLSVILDVEDAVSGLAISSLRQAFHSIKEVTTLGDLSAEAWALQSTSRWDAVVAAVVTISQIAVSYDHSSASVVLRSGKRISDFVELLSVVAEGFPAIVPEDESRRVAQHFAHIVLARNASRALKGMLCGLVGTGDNISINDKRRDEDKTFLRCLSNNDRARCIRTLMRCPALRLSACDIPCSLTDLSWSNVLAQYYGCVYDVIFLLCSCMDQSAVPELVHELEEYGLDQVERCWESNLTSIYGILSWVASAPASPKGDSSVNIDRRSIINAMFGHLGVAGGRDHCRMTVLAFDALRCGVECEEELVKTHIYRTLLDEAQSERAGYIAAVTLSTEVLRDPESNWLRLKELLLHVAVLHNPSREEEGAEVLVAALEPLMLKAWPESLRVQYPPTVRLSYVGRAMAISAILCCCFKKEEWAADVTLQLLEWNNSNPAVNHEPCMPNSKAHRSRMRLWQLLCALVPMVRSPTVQRDLLHVVVMKCLTLTNMGSVRRLMELFALQLLQRQPQLYWIIDNAMANYQLRPQVIGSYVFISAHVILRELRGEVEPVDGLMDTLLHRLFQQSTSHQHMLRLVCHIGLNFIREASVARGIVFSANEESIFDYVANAPEHVKFRVQHAEQLFFDVREACTPRQLFCIQRREGNNILLVSIPAVAFERMRFIDREVACLTGVLTPVDQIRVQVLMQHFEASRVLEPLKEFPYIPHTKSTALFCVDYTPEAVAVLTADTHISEGMSSVTGYENVQRKATPWWSSQLYDELHPRALKTERQPVIVIASLLQNPVNVAGLFRCGEVFAVEKVVVSDAAVLEHPHFVAAARSSDLWLPWSAVQVKALSGYLSSLRQDGYTLVGIEQTAGSVPMSSYQFPKRAVIVLGAEGHGIPAQLLTVLDVCVEIPQYGLIRSLNVHVTGSIVMYEYTRQHRMGGAPESS
Protein: Neurobeachin-like protein 2 (Q6ZQA0)
Organism: Mus musculus (Mouse)
Function: Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
Sequence:
MAASERLYELWLLYYAQKDLGYLQQWLKAFVGVFEKTISLSSLEPRRPEEAGAEVPLLPLDALHALAEQLDQDDLDQALLLLKLFIILCRNLENVEAGWGQVLVPRVLALLTVLMAELKGSSQESHGTQLENVALHALLLCEGLFDPYQTWRRQLTGEVISSKEKSKYKFPPAALPCEFGAFFQENLQDAERLPPTLLLRLIHLFGAILAGGKANGQMAVSAGSVQGLLGVVRGWGRGPAQDPQQVPLALRALVGAVHVLHASRAPPRGPELRTLLEGYFHILNADWPTSPSSSPEEALVTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLIRLIQNSKLYLQARAPPEGDSDLATWLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSGSPSAKEVFKERIGYQHLQEVLQSHGPPTHRLLQELLNMAVEGDHSMHPPPPIRNEQPVLVLMQWLPALPTAELRLFLAQRLWWLCDSCPASRTTCVQAGLVGYLLETLNTGTALGARCQEQLLALLQALGRVSLRPLELRRLLRPPPGLDSESSGNESQKARHAGAVIRALSGMARHRGPARALRYFDLTPSMAGIMVPPVQRWPGAGFTFHAWLCLQSSEAVPTSAPSRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYVTVNLPEVSFADSAWHCVAIVHVPGRRPFSQNLVNVFKDGHLVKTVPFRFPSLSEPFSSCCIGSAGHRTTTTTTGLPASSVSTALAHTHPSLTRSQSVPASTGLGWGPGLGTPLQEGSVSSTLAGTQDTRWGSPTSLEGELGAVAIFHEALQPSALRVLCSLGPNEPAPFKPEGELHEFGTKLLLHYSPQACKNNICLDLSPGHGLDGRLTGHRVETWDVKDVVNCVGGMGVLLPLLERVAVQPQEAEAGPCETHDLVGPELTSGRNTQGLLLPLGKSSEDRMERNAVAAFLLMLRNFLQNHTVNQESLVQCQGPAIIGALLRKVPSSAMDMNVLMSAQLLMEQAAADGGGPLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSMVREHRQKLRKKYGVQFLLDALRTHYSPQRERPLAADDLRTVQTSLLGLVREFLVRNFSVEDMQVVLNFLAATGDDGQVVGTLELLLTLLQGSPVQDPLAAFLLELGNLEVLLALLVRPKSTPLLTDRVCKILRRLQQNERLPERNRQRIRLHDCGLQGLVASLSEESISPQLCQGLYKLFVGTDCLNLSDLLAVVQLSLQADLSVRLDICRQLFYLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATDSSPPRFLPELPISSELALSPPPTELPADSSDVFLPSESPCPDQDAFYQALSPFSTPFDLGLERASIGSGNTAGGGSSNGTVTPASQPGTPSPLDGPRPFPTAQGRHSSSLSNVLEDGSLLEPNISGDDTSNTSNPQQTPEEELCNLLTNVLFSVTWRGVEGSAEAAWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMMLESALTDIKEAPPGGLANLSQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCNLLDRLGAWPHLANSTADLREMAQIGLRLVLGYILLEDPQLHAQAYVKLHTLLQTAVPTRREEACYVLSKLEAALSRALTTSSSETEHASTAVAASERCSWLVPLVRTLLDRAYGPLGLQWGLPSLPPTNGSPTFFEDFQAFCATAEWRHFIDKQVQPTMSKFEMDTYAKSHDLMSGFWNACYDTLMSSGQRHQRDRIQSRRAFKELVLEPAQRRARVEGLRYASVLKQQAAQHSTALLHWGALWRQLSSPCGAWALRIPPAPHWKLSSAETYSRMRLKLVPNHHFDPHLEASALRDNLGEAPMTPTEETSLPLAVTKEAKISAPPEELPEEQLGEEDLAALESLMEAAELDEKREKLVLSAECQLVTVVAVVPGLLEITTQHVYFYDGSTERVETEEGIGHDFRRPLAQLREVHLRRFNLRRSALELFFIDQSNYFLNFPHKVAASSASSPCQAPRPQLYPIPSHTQLRNQVYSLLLRLRPPTQGYLSSRSPLEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPVLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWAGSPEDFIQKHRQALESEYVSTHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVADERERKALEGIISNFGQTPCQLLKEPHPPRLSAEEAANRLARLDTNSPSIFQNLNQLKAFFAEVVSEAVPLVLALVPHRQSHSFITQSSSDMLVTVSASGLLGTHTWLPYDRNINNYFTFSKDPTMGSPKVQKLLSGPWVSDSGVSAQALAVAPDGKLLFSGGHWDGSLRVTSLPRGRLLNQLSRHLDIVTCLALDTCGIYLISGSRDTTCMVWRLLQQSGLSAGLAPKPVQVLYGHVAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPPGATLPGPISHLALGAEGQIVVQSSACERPGAQVTYSLHLYSVNGRLRASVTLTEQPTALTVAEDFVLLGTAQCSLHILHLNKLRPAVPPLPMKVPVHSVSVTKERSHVLVGLEDGKLIVVGAGQPSEVRSSQFARRLWRSSRRISQVSSGETEYNPGEAR
Protein: Obg-like ATPase 1 (O13998)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity). Negatively regulates the G2/M transition in the cell cycle.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Translation machinery-associated protein 20
- Mitosis inhibitor nif1
Sequence:
MPPKKQQEVVKVQWGRPGNNLKTGIVGMPNVGKSTFFRAITKSVLGNPANYPYATIDPEEAKVAVPDERFDWLCEAYKPKSRVPAFLTVFDIAGLTKGASTGVGLGNAFLSHVRAVDAIYQVVRAFDDAEIIHVEGDVDPIRDLSIIVDELLIKDAEFVEKHLEGLRKITSRGANTLEMKAKKEEQAIIEKVYQYLTETKQPIRKGDWSNREVEIINSLYLLTAKPVIYLVNMSERDFLRQKNKYLPKIKKWIDENSPGDTLIPMSVAFEERLTNFTEEEAIEECKKLNTKSMLPKIIVTGYNALNLINYFTCGEDEVRSWTIRKGTKAPQAAGVIHTDFEKAFVVGEIMHYQDLFDYKTENACRAAGKYLTKGKEYVMESGDIAHWKAGKR
Protein: Multidomain regulatory protein Rv1364c (Anti-sigma-F factor Rv1364c) (Anti-SigF factor) (Protein-serine/threonine phosphatase) (EC 3.1.3.16) (Putative multidomain regulator of SigF) (MursiF) (Serine/threonine-protein kinase) (EC 2.7.11.1) (P9WLZ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Interaction partners:
- FO synthase
- Uncharacterized protein Rv1354c
- Anti-sigma-F factor antagonist RsfA
- Anti-sigma-F factor antagonist RsfB
- Anti-sigma factor antagonist
- Putative anti-anti-sigma factor Rv2638
- Osmosensory protein A
- Anti-sigma-F factor RsbW
- RNA polymerase sigma factor SigF
- Bacterioferritin BfrA
Sequence:
MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
Protein: DNA (cytosine-5)-methyltransferase (EC 2.1.1.37) (Q54JH6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in epigenetic gene silencing. Methylates specific cytosine residues in the retrotransposons DIRS-1 and Skipper.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- RNA helicase
- tRNA
- Inosine-5'-monophosphate dehydrogenase
- Queuine tRNA-ribosyltransferase catalytic subunit 1
- Chromo domain-containing protein
- RNA-directed RNA polymerase
- S-adenosylmethionine synthase
- RNA-directed RNA polymerase
- RNA-directed RNA polymerase
Sequence:
MEQLRVLEFYSGIGGMHYGLQESGVDFQVIQSFDINTNANLNYKYTFNEDSSQKSIESYSVEELEGFKANAWLMSPPCQPFTRLGLQKDDQDNRTNSFFHLLDVLTKIKDPPTYILIENVFGFAKKGSSNTRDHLLDTLIKMNYSFQEFHLSPQQFGLANQRLRYFCIAKRNGKLNFKKEQDKHNEKVDENKLNNNSNNNNEQNKYDNLKILDHIPGYDFHTTLEECDEISNYFDKDLTDDELYEKYKVPHNLLLSKGMLFDIKQKDSKTSNCVTKSYGKFIEGTGSIIQMDNNFKADINDNKSLIPLKLRYFSPKEITRLHGFPEEFKFSPKLTTIQCYRLIGNSLNVKIVSELLKVLVSPNEEEEQQEQQKEKEGKK
Protein: Ras GTPase-activating protein gap-2 (GTPase-activating protein 2) (Q8MLZ5)
Organism: Caenorhabditis elegans
Function: GTPase-activating protein, which acts as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. The different isoforms may play a distinct role in specific tissues.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- SH2 domain-containing protein
Sequence:
MKVIDEKPEDEEEEKDSGSKCKTPSSCTKKRVREKEEDLPPICHGWLIVCEGNPTKMMNKEVKLPWHAGYCVFEPRQSTMSCYKQEYPFIAGRMLHRNRTVRMDGDRSAFARHWGLLPEHYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMSIEFFDAIHDETNSGGAQVGGESLDRRGWSGASTGNRTTLTASVHNNLMNGRMSSSSHNLSTRLSGSTQNLNQPTNAYGNLLSRPFRSNPLKRTKSVSKMEKSLAEANQHSLHRVDASNTPSRDSSLYAQPPARRHLSQPAREGSLRACRSHESLLSSAHSTHMIELNEDNRLHPVHPSIFEVPNCFRLASTYYSCRTPLERAKWMENLRKTMNPRRDQQRRTENSMLIWILEAKGLPAKRKYYCEMTLDKTLYAKTSSKARTDNVFWGENFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLSSRSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLETLCYNYLPLCEQLEPVLNVRDKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESKSGPEKNADAIVDAGKELSLIATYLEEAWTPLLQEKNGNKHPLSNVKSVLSELAECKRRSDNGVFHSPMVQQPSSDYENSPQQHVVPRHENVPAYRSTPPTGQATVLGRSTNRPATHLLTSDDYVLSSAFQTPSLRPGGTRLSDETGTSSSRTSDKTTSSAEIRDDTDSDFELREDRGRGGRNRKRLPRTDASPSSSQQASSGYLSNNPSRSSYSNSSSSSPVERMAALSIANPVFGPGPSSGYAIPAEPKEIVYQKRASPPPYDPDVHNYHYQPMQVYAVPPDCQVSPRTQATGGVNAQNRLSLPRTNPRASRNSTLLRPSVVNVPDDWDRTSDYWRDRGENNYRSQLESQVESQAREIERLMRENIELKSKMMSSTKTVDSKRSDSGASEDSYDSLSSLDRPSRQSLVVVPN
Protein: At1g09500/F14J9_16 (F14J9.16 protein) (NAD(P)-binding Rossmann-fold superfamily protein) (O80533)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g39520
- Protein CHLOROPLAST VESICULATION
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- von willebrand factor A domain protein
- Cytochrome P450 76C2
- F18B13.24 protein
- Defensin-like protein 206
- Alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial
- At3g45160
- DNA binding / transcription factor
Sequence:
MADGGKVVCVTGASGYIASWIVKLLLFRGYTINATVRDPKDRKKTDHLLALDGAKERLKLFKADLLDEGSFELAIDGCETVFHTASPVAITVKTDPQVELINPAVNGTINVLRTCTKVSSVKRVILTSSMAAVLAPETKLGPNDVVDETFFTNPSFAEERKQWYVLSKTLAEDAAWRFAKDNEIDLIVLNPGLVTGPILQPTLNFSVAVIVELMKGKNPFNTTHHRFVDVRDVALAHVKALETPSANGRYIIDGPVVTIKDIENVLREFFPDLCIADRNEDITELNSVTFNVCLDKVKSLGIIEFTPTETSLRDTVLSLKEKCLV
Protein: Interleukin-22 (A0A060ZWP7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Fibronectin type-III domain-containing protein
- Fibronectin type-III domain-containing protein
- Interferon/interleukin receptor domain-containing protein
- Fibronectin type-III domain-containing protein
- Interferon/interleukin receptor domain-containing protein
- Interferon/interleukin receptor domain-containing protein
- Interferon/interleukin receptor domain-containing protein
- Fibronectin type-III domain-containing protein
- Interferon/interleukin receptor domain-containing protein
- Interferon/interleukin receptor domain-containing protein
Sequence:
MKFSTVQLVAAVVVVMSVCLLRESVAHSIHRPLSAPLHSADTDTMVQQVAQHAQSFDTDTDTKLMPDIETKKNHRDICCLHANILDFYLSNILTTKEKQDKHHPKLPALKEDLARVSRDLKEHGCAIKHYNDHHHSIAFRKKLSEMEEGKGSRKPLERLTSSSPS
Protein: Olfactory receptor (Q9QZ20)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MDVSNQTTVTEFVLLGLSAHPKLEKTFFVLILSMYLVILLGNGVLILVSILDSHLHTPMYFFLGNLSFLDICYTTSSVPLVLDGFLTPRKTISFSGCAVQMFLSFAMGATECVLLGMMAFDRYVAICNPLRYPVVMNKAAYVPMAVSSWVAGGANSLVQISLAVQLPFCGDNVINHFICEILAVLKLACADISINVISMGVANVIFLGVPVLFIFVSYIFILSTILRIPSAEGRKKAFSTCSAHLTVVIIFYGTILFMYGKPKSKDPLGADKQDLADKLISLFYGLLTPMLNPIIYSLRNKDVKAAVRNLASHRCLTF
Protein: Protein PTST homolog 2, chloroplastic (PROTEIN TARGETING TO STARCH homolog 2) (Q9LFY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in starch granule initiation in leaf chloroplasts. Binds and delivers suitable maltooligosaccharide substrates to starch synthase 4 (SS4).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:28684429, ECO:0000269|PubMed:29866647}. Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:29866647}; Peripheral membrane protein {ECO:0000305|PubMed:29866647}; Stromal side {ECO:0000269|PubMed:29866647}. Note=Colocalizes with MFP1 to small patches distributed throughout the chloroplasts. {ECO:0000269|PubMed:29866647}.
Interaction partners:
- Low-density receptor-like protein
- MAR-binding filament-like protein 1
- Protein TRIGALACTOSYLDIACYLGLYCEROL 2, chloroplastic
- Inner membrane localized protein
- Low-density receptor-like protein
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic
- Probable starch synthase 4, chloroplastic/amyloplastic
Sequence:
MVSINSGPISSFVSRYSMIDSDTLLHLSSFGSTFNPNYKAKACIRFARKVCGSTVLGFLEVKPRKKSCCSRCNGVSRMCNKRNLGWDSEGSKDLETEILEFMKNSEKPGMFPSKKDLIRSGRFDLVERIVNQGGWLSMGWDLDEQEEKVRVNENVTPQDLHIEKQLPNCNSPEMDKTLNHGDLDLSSNLSSSTEQVESRNDSGIEGILTRLEKERNLSLGISVRENGKSNGAMHDISPNGSVPWSSRIVTASEIQEVDGSRGSGEYAQSRYQGAKSVSGKPGLSDSPTSETWRTWSMRRAGFTDEDFEAAEISSSGLTGVKKDDTKKDSGDSMNGKDRIASSSEDVNKTHIKHRLQQLQSELSSVLHSLRSPPDKVVTSKDSETTAGNLENLSDDWEYKENEIIHAQNKLRSTRAKLAVLEGKMAMAIIDAQRIVREKQRRIDHASRALRLLRTASIVWPNSASEVLLTGSFDGWSTQRKMKKAENGVFSLSLKLYPGKYEIKFIVDGQWKVDPLRPIVTSGGYENNLLIIS
Protein: Abl interactor 2 (F8WAL6)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLASVAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWLLRFKVSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSLAPPPPSILQVTPQLPLMGFVARVQENISDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE
Protein: V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (Vacuolar proton pump subunit e 1) (Q9CQD8)
Organism: Mus musculus (Mouse)
Function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit D
- V-type proton ATPase subunit C 1
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit F
- V-type proton ATPase subunit H
- Ribonuclease kappa
- V-type proton ATPase subunit S1
Sequence:
MAYHGLTVPLIVMSVFWGFVGLLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP