wanglab/gogpt-training-data huggingface dataset:
Protein: Complement C5 (Hemolytic complement) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] (P06684)
Organism: Mus musculus (Mouse)
Function: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Subcellular location: Secreted.
Interaction partners:
- C5a anaphylatoxin chemotactic receptor 1
- C5a anaphylatoxin chemotactic receptor 2
- Complement component C9
- C3a anaphylatoxin chemotactic receptor
- Complement component C8 beta chain
- Complement component 6.
- Complement component C7
- Complement component C8 alpha chain
- Prothrombin
- Complement component C8 gamma chain
Sequence:
MGLWGILCLLIFLDKTWGQEQTYVISAPKILRVGSSENVVIQVHGYTEAFDATLSLKSYPDKKVTFSSGYVNLSPENKFQNAALLTLQPNQVPREESPVSHVYLEVVSKHFSKSKKIPITYNNGILFIHTDKPVYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKANYKKDFTTTGTAYFEIKEYVLPRFSVSIELERTFIGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLREDIKDEEKQMMHKATQAAKLVDGVAQISFDSETAVKELSYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYTLNLVATPLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMAQTVDVNQETSDLETKRSITHDTDGVAVFVLNLPSNVTVLKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTPKSPYIDKITHYNYLILSKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVYKVQGNAKRAMQRVFQALDEKSDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSKRNLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIRKESPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLWEIHRVPKRKQLQVTLPDSLTTWEIQGIGISDNGICVADTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTSGTKFCVKMSAVEGICTSGSSAASLHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIGLHSINFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVERILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYPDTLSKRQSLEKKIKQGVVSVMSYRNADYSYSMWKGASASTWLTAFALRVLGQVAKYVKQDENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPTMKIHTALDKADSFLLENTLPSKSTFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSSVPSSGTAGMVETTAYALLASLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLKQIHLDMDINVAYKHEGDFHKYKVTEKHFLGRPVEVSLNDDLVVSTGYSSGLATVYVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLSDSGFKRIIACASYKPSKEESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQLLTDYQIKDGHVILQLNSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAACTCVEADCAQLQAEVDLAISADSRKEKACKPETAYAYKVRITSATEENVFVKYTATLLVTYKTGEAADENSEVTFIKKMSCTNANLVKGKQYLIMGKEVLQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQAFVENLNNFAEDLFLNSCE
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q9U5E0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAHESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKADKALEMFHRLCMDDAFKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKESQDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQRPQSLKEVPKALKDRKGFKQENSKQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPESSSSDRELELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQHLFGSFKSESEESNQSLNCFKTARQMLEENNAKLKGVPEKLPIKDGEKGVLENRADSIGFTSAREMLERSKQREGDDKSSNKLEKLGFISAREMLEKNKLNERCLDKKDVKEKKLESRETKRSLQNNELQHKQEEDRKDKASHRKTSKESLSNLKKEGSDSRALQKDTKPETRNHQKTDVSKNVVQWLNPYYKRKIATKELFKALAKLLTQRICDGSLGDGDAGKCYIKETFHGLHMINNDQDIEKYFIKSK
Protein: Nicalin (Q8MZ34)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MMNEADSLTEIFRGGLPHCLLIVFSLLLTCSPVMPSEFEVISMSKYDLNGQHYGSRVASISLEARSLYSWNTSRHCVLTRLTDLSIHDFDKLRQGAGGLILMLPANILNLDPETKELITILEQSMLTHTAAVPIYFAPYNKDLEKIIDDITYTTTDSPGQNQTALAQLVVTVSANRYHINVGGGSIAANKNSKIPIIHGELIPNQLALKPTESVADGQKLPVILITANLKTFGIYNDYPVNADAAVLLVLMELFSKLHYTSSMAPKYRLRFLLSDAGVLLNFQGSKKWLEVDDNALQNVEFMLCLDTISESLSYTTENALYMHVSKPPKDKTSISNFFKLLKSSAEKYSNGLAVEGVHKKINLADTKLAWEHERFSIKRYPSFTLSSVKSPRSPIRTTIFKNDESRLVEHTLNTTRIIAEALASFMYKVDPTSSIFEGQLAIKEENILPYFGVKSILHNNDVKDAFEKYLNNVKIIYDKPDARDPEFMFYNENEVKLNVYRVKPAIFDLFLTFVIGAYLLAVFLAIQYFPRFYDEVSELTKEDPAGQSNGHSSERVRMKSH
Protein: Protein pid-1 (PiRNA-induced silencing defective protein 1) (Q19541)
Organism: Caenorhabditis elegans
Function: Component of the pid-1 variant of the PETISCO complex which is required for the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs). Within the complex acts as an adapter which binds to the complex via erh-2. Involved in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing. Plays a role in small RNA-directed transgenerational epigenetic inheritance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24696453, ECO:0000269|PubMed:31147388, ECO:0000269|PubMed:31216475}. Nucleus {ECO:0000269|PubMed:24696453}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:31147388, ECO:0000269|PubMed:31216475}. Note=Expressed predominantly in the cytoplasm (PubMed:24696453). A small fraction is nuclear or located near the nucleus (PubMed:24696453). Dispersedly distributes throughout the cytoplasm in early embryos (PubMed:31147388). Localizes to puncta in the perinuclear region in the germline syncytium (PubMed:31147388, PubMed:31216475). {ECO:0000269|PubMed:24696453, ECO:0000269|PubMed:31147388, ECO:0000269|PubMed:31216475}.
Interaction partners:
- Enhancer of rudimentary homolog 2
- Protein tost-1
- Embryonic developmental protein tofu-6
- Enhancer of rudimentary homolog
- Protein pid-3
- Uncharacterized protein ZK1320.5
- Eukaryotic translation initiation factor 4E-3
- Schlafen-like protein 1
- Schlafen-like protein 2
- Uncharacterized protein
Sequence:
MSAKREFSHITLASTPFKKRIDQNSLKTDSDIEKDTNIAHKCAERFNYNTNLHRKVTLSDRFELAALGYEMKAKPRTIIEKHNDCDEFHFIYRKEKKNDYGTGSPLSAGLSLSNPLPAGRGFLSPAIQNTSNQFTFSGSPRITPQKHTPVSANHKPARSIFDDIPSNIA
Protein: Complement factor H-related 2 (Putative complement factor H-related protein B) (Q4LDF6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Complement factor H-related 1
- Complement factor H
Sequence:
MGFCSMLLLSNILLTAWLSTAKGEEKTCSPPYILNGIYTPHRIIHKSDDEIRYECNYGFYPVTGSTVSKCTPTGWIPVPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYKCDNGFSPPSGYSWDYLRCTAQGWEPEVPCVRKCVFHYVENGDSTYWEKIYVQGQSLKVQCYNGYSLQNGQDTMTCTENGWSPPPKCIRINSTRTCGPPPPIDNGDITSLSLPEYEPLSSVDYQCQKYYLLKGNKTITCRNGNWSEPPMCLHACVIPENIMEAHNIILKWRHTEKIYAHSGEDIEFECKRGYQKARGSLPFRTKCINGTINYPTCV
Protein: Neuron navigator 2 (E9PNV5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLWPRNLTSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLPRPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENMKNSVVISNPHATMTQQGNLDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSLTPFVRTNSVKTTLSERYTPTSQLRTQEDAKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSGTRFNFSQLASPTTVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESD
Protein: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform BRB) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) (P36877)
Organism: Rattus norvegicus (Rat)
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
Subcellular location: [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.
Interaction partners:
- Protein phosphatase 2 scaffold subunit A alpha
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Protein phosphatase 2, regulatory subunit B'', alpha
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
Sequence:
MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTAKVWDLNMENRPVETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN
Protein: Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47) (P97829)
Organism: Rattus norvegicus (Rat)
Function: Adhesive protein that mediates cell-to-cell interactions. Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling (By similarity). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity). In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type substrate 1
- Platelet glycoprotein 4
- Thrombospondin-1
- Lysosome membrane protein 2
- Receptor-type tyrosine-protein phosphatase C
- CX3C chemokine receptor 1
- Vascular endothelial growth factor receptor 2
- Scavenger receptor class B member 1
- Integrin beta-1
- Ubiquilin-1
Sequence:
MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN
Protein: CAAX amino terminal protease family protein (Q8VZ58)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein SNOWY COTYLEDON 3
- Riboflavin synthase
- Preprotein translocase subunit SECE1
- Splicing factor Cactin
- Thermosome subunit gamma
- Protein translocase subunit SECA2, chloroplastic
- Protein disulfide-isomerase SCO2
- Probable CCR4-associated factor 1 homolog 2
- At2g41950/T6D20.26
- Uncharacterized protein
Sequence:
MLTSSCSSSSLLCHRPALSSSRSKFRVPCRTVFSPALTKISPLTASSPSKSAKHKWKILCFRNEDSAPENPEHFVPEELVKPDQDSPCTDKTDWKATFQKAADAVLKAIGTRWKVPWTVETIVQVMLLWVAAFWFIGSWMIPFMAHISGFHKESLTFRGQALFSLITDVTEGLAGIAILHRCLSMFRPLASDWFRFTLKGNWQLDVIIGCFMFPFVNRLSQLNLNLLPLPPTSSPVSLSSVEQSIMARDPVAMALYAVVVSICAPVWEEIVFRGFLLPSLTRYMPVWCAILVSSIAFALAHFNVQRMLPLVFLGVVLGLIFARSRNLLPSMLLHSLWNGFVFMELMR
Protein: Formin homology 2 domain containing, isoform F (M9NE63)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLYVDGMNGVMKHEPTMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLGAGIPPPPPPLGGAIAPPPMMPPSLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESRAKDLMTKKQQELNKSKEIIVLDHKRSNAINIAITKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPITRQSEEQFTDGDDEILESLVKTATKAPGTRTTPRERKRTRHADRKSLKRSRTREGFTVERAPSP
Protein: Citrate synthase, mitochondrial (EC 2.3.3.16) (Q553V1)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- malate synthase
- Probable aconitate hydratase, mitochondrial
- Probable cytoplasmic aconitate hydratase
- Probable ATP-citrate synthase
- Probable malate dehydrogenase 2, mitochondrial
- ATP citrate synthase
- Probable malate dehydrogenase 1
- Probable malate dehydrogenase 3
- isocitrate lyase
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Sequence:
MFARLARANYLKNSGRYFSTEPTLKERLVQIIPGKIEQVKQLKTEHGDKIIGTCTVAQAYGGMRSVKSLVTETSSLDPEEGIRFRGLTIPECQEKLPKAPGGAEPLPEGILWLLLTGEVPTESQVKTLSKDLAKRAGLPKHVTSMIKAFPEQMHPMSQLAAAILALQGESKFVKAYNDGVKKDKYWESTLEDSLDVIAKLPEVAALIYQNTYKKSDITHKIDENLDWSANFNRMLGYTSKDFDELMRLYLTIHTDHEGGNVSAHTTHLVGSALSDSYLSLSAGMCGLAGPLHGLANQEVLSWTMKLQEKLGNKEVSNEVLSEAIWEGLNAGRVVPGFGHAVLRKTDPRYTCQREFALKHLPQDPLFKLVSQIYEVVPDILTKHGKTKNPYPNVDAHSGCLLQYYGLKEHNFYTVLFGVSRAIGVLSSLVWDRILGHPIERPKSVTTEWISSYVNSDQSKK
Protein: Chemosensory protein B 38a (Q7KT13)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MISISTILALVVSSVWATDYTLEFEDSDLYSECSEKLPGAIGLREAFDMRNIVTELDIDGLHLSGNCTTIWDVPSTDRISLRMTVMHFDRGTWQPTVFNTYARDFCAVMFDKELSWYKYWLKYFANREEISEKCIGTKGTVLVYKPFIVKPLIQNVIGPIYRGRVKAIFNFESFDKNNVKGATDVCFEVRGQVEKIK
Protein: ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Translation initiation factor 1) (P47943)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Eukaryotic translation initiation factor 4 gamma
- Probable eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit I
- Probable RNA-binding protein sce3
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 5B
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 4E-1
- Eukaryotic translation initiation factor 3 subunit D
Sequence:
MVDQLEDSVIETNYDEVIDTFDDMNLKPELLRGIYAYGFERPSAIQQRAIMPILGERDVLAQAQSGTGKTATFSISVLQKIDTSLKQCQALILAPTRELAQQIQKVVVALGDLMNVECHACIGGTLVRDDMAALQAGVHVVVGTPGRVHDMIQRRALPTDAVQMFVLDEADEMLSRGFKDQIYDIFQLLPPTAQVVLLSATMPQDVLEVTTKFMRDPIRILVKKDELTLEGIKQFYVAVEKEEWKLDTLCDLYETVTVTQAVIFCNTRRKVDWLTEQLTERDFTVSSMHGDMDQAQRDTLMHEFRTGSSRILITTDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVSINFVTNDDVRMMREIEQFYNTHIEEMPMNIADLI
Protein: Apelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler) (P0DMC2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Involved in cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:24407481}. Secreted, extracellular space {ECO:0000269|PubMed:24407481}.
Interaction partners:
- Apelin receptor A
- Apelin receptor B
- Apelin
- Apelin receptor 2
- Arrestin, beta 2a.
- Arrb2b protein
- Beta-arrestin-1
Sequence:
MRFFHPLYLLLLLLTVLVLISADKHGTKHDFLNLRRKYRRHNCPKKRCLPLHSRVPFP
Protein: G protein subunit alpha transducin 2 (D4AA42)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Rhodopsin
- Phosphodiesterase
- Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Guanine nucleotide-binding protein G
- Phosphodiesterase
- Guanine nucleotide-binding protein subunit gamma
- Regulator of G-protein signaling 9
- G protein subunit alpha transducin 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MGSGISAEDKELAKRSRELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECLEFKSVIYGNVLQSILAIIRAMSTLGIDYAEPSCAEAGRQLNNLADSTEEGTMPSELVEVIRKLWKDGGVQACFDRAAEFQLNDSASYYLNQLDRITDPDYLPNEQDVLRSRVKTTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYEDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
Protein: Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141) (P07204)
Organism: Homo sapiens (Human)
Function: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Endothelial protein C receptor
- Prothrombin
- Vitamin K-dependent protein C
- Tissue factor
- Proteinase-activated receptor 1
- Tissue factor pathway inhibitor
- Carboxypeptidase B2
- Coagulation factor VII
- Complement C3
- Tissue-type plasminogen activator
Sequence:
MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
Protein: Invasin CotH2 (Spore coat protein homolog 2) (I1C4E4)
Organism: Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar)
Function: Promotes invasion of host epithelial cells by adhering to receptors on the host cell surface to facilitate endocytosis of the pathogen into host cells. Binds HSPA5/BiP protein on the cell surface of host epithelial cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24355926}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- MHD domain-containing protein
- Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain domain-containing protein
- Protein kinase domain-containing protein
Sequence:
MKLSLTIVSSSFLVAIAHAASVQFNLIAPSATDVKVSVNGQQVALTASDPNVPYFTGSAEVGGTEESFERSLAGITNSTFNDFYNRPVTYANLPQLPWPIENDPQWTRKGKKAEIFDDNYIPSVFFHGDDSQVQDLVKNVPKDKVTGTLTFIGSNYVHSFANVSFGIHGAGKKHNNAKQSWKWTLSGTDTMGNRNHFKLRHMEEDPTQIRERLYADILHAMGTYANETTMVRLFINGQGFGTFNMLDDITEFSYINAMFYGGNPPATLGPLFDGASGADFIYHPGNLDGYSSWKPNKDNANGEGYEAFDPLCKAWNETDYTDNTAIANFEKMFDTEHFLRFMVIEYLTAHWDGYWMGQTNDGAYRDPSDNNKWYFLDQDFDATFGVNLDVPENKDFISVSYKDFPSRYPAGVMANGLLQNADKKAKFEQYLTETVRVLFNNVTLTNRVLAIHNFLSPDLEWDRSIVQQSPGTNFGWTFEQTSQNLWQGVSAPNNNGGGAEWGLVEYIAAKSQAMAKEFNITIVSEPVGPPAANGTATSTNDGGNTHTAAGESKPASSSESSGSKIASQSVSGASRSAVSTVLLGVTALVATAIF
Protein: Uncharacterized AIM2 family protein C977.15 (Q9P7U1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pdp3-interacting factor 2
Sequence:
MPCCPTKSGAAPTNRNYELQGEMLKDIGGMQTYFTGKRSSKVVLIGFMDVFGLSKQIKEGADQLANHELAIYLPDFLNGETASIEMIDPKTIEQKEARSKFMEKISSPLHWPKLTKVIEDIERIHGQDVKIGAYGFCWGAKVLITYPNKERFLRIGCAHPSLLDPVDAKHVHCPVCFLCSKDEDPEEVDAWKKSFENSPYFSESYFETFGKMHHGWMAARANLSDPENRKYFDLGYQIFLKFFKELF