wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) (Q9UHF7)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Subcellular location: Nucleus {ECO:0000269|PubMed:12885770}.
Interaction partners:
- Exostosin-1
- Eukaryotic translation initiation factor 3 subunit H
- CUB and sushi domain-containing protein 3
- C-terminal-binding protein 1
- Dynein light chain 1, cytoplasmic
- Annexin A13
- Histone deacetylase 2
Sequence:
MVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHIQRGLHRNNAQVEKNGKPKE
Protein: 1,8-cineole synthase, chloroplastic (EC 4.2.3.108) (Terpene synthase TPS-Cin) (PgTPS-Cin) (F2XFA2)
Organism: Picea glauca (White spruce) (Pinus glauca)
Function: Terpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to 1,8-cineole.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALVCGAPLASRSCLNKSLISSTHELKPLRRTILPTLRWKSATPSINMCLTTSNSVDAVQRRIANHHSNLWDDDFIQSLSTPYEAPSYRERAERLIGEVKEMFESMGPNNDLLQRLSMVESVERLGIDRHFKNEIKSALDYVYSHWNEKGIGCGRDSVVSDLNSTALALRTLRLHGYPVSSDVLEHFKDQKGRFACSSIKTEGEIRSLLNLFRASLVAFPNEKVMEEAEIFSTTYLKEAVQKIPVSSLSRQIEYNMEYGWHTNLPRLEARNYMGDMIHVMPYMNAEKLLELAKLEFNIFHSLQERELKHLSRWWKDSGFSQLTFVRHRHVEYYTLASCIDIDPKHSAFRLGFAKMCHLITVLDDIYDTFGTMDELKLFTAAIKRWDPSATEWLPEYMKGVYMVVYETVNEMAGEAKKSQGRDTINYARQAWEAYIDSYMKEAEWISSGCLPTFEEYYENGKVSFGYQISVLQPILTLDVPLPHHILQEIIFPSRFNGLASGILRLKGDTRCYQADRARGEEASCISCYMNDNPGATEEDALNHIHAMVNELMKEFNWELLKPDNNVPVSSKKHAFDITRAVHHGYKYRDGYSVANNEIKNLVITTVLEPVPL
Protein: PIH1 domain-containing protein 2 (Q5PRB3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- RuvB-like 1
- RuvB-like 2
- RNA polymerase II-associated protein 3
- Sperm-associated antigen 1A
- PIH1 domain containing 3
- PIH1 domain-containing protein 1
- Nucleolar protein 58
- Dynein axonemal assembly factor 10
- TOG domain-containing protein.
- Dynein axonemal assembly factor 4.
Sequence:
MAIHGYDGKAALQQVNQFWSMLDDMCENNPEEYRSFIQRQMREGAEFHSPPQSHTCIRTAVLGANEGILYINICGWKRVPAPASDKEPVPVCGGRMEKLTEEKEEYSVVDAAFNPEVLQTTEKDKEEKENLCLLALNFIQQQHNLTLSQHYKLTNDKIKGSIRDTKQRLMSTKTCKSTLNGSQSEPAPSLLQQICSLQNTESDEDSSIELSIEQERKPARSGLIEVISSTELDQPQPQLPKHQLTICPDGNGSSRILQLCVELPGVRSVSQCQLRISEDDILLEVEDIYYLLLPFPELVKEETCTAKFNKKKQTLNVTVNVL
Protein: Uncharacterized protein YahF (P77187)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YahG
- Oxamate carbamoyltransferase subunit AllG
- Succinate--CoA ligase subunit beta
- Uncharacterized protein YahE
- NADH-quinone oxidoreductase subunit C/D
- Putative ankyrin repeat protein YahD
- Uncharacterized protein YfaA
- 2-oxoglutarate dehydrogenase E1 component
- Oxamate carbamoyltransferase subunit AllH
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
Sequence:
MSVKIVIKPNTYFDSVSLMSISTRANKLDGVEQAFVAMATEMNKGVLKNLGLLTPELEQAKNGDLMIVINGKSGADNEQLLVEIEELFNTKAQSGSHEARYATIGSAKKHIPESNLAVISVNGLFAAREARQALQNDLNVMLFSDNVSVEDELALKQLAHEKGLLMMGPDCGTAIINGAALCFGNAVRRGNIGIVGASGTGSQELSVRIHEFGGGVSQLIGTGGRDLSEKIGGLMMLDAIGMLENDPQTEIIALISKPPAPAVARKVLERARACRKPVVVCFLDRGETPVDEQGLQFARGTKEAALKAVMLSGVKQENLDLHTLNQPLIADVRARLQPQQKYIRGLFCGGTLCDETMFAVMEKHGDVYSNIQPDPEFRLKDINRSIKHTFLDFGDDDFTNGKPHPMIDPTNRISRLIEEARDPEVAVIVMDFVLGFGSHEDPVGSTIETIKEAKAIAAAEGRELIILAYVLGTDLDTPSLEQQSQMLLDAGVILASSSTNTGLLAREFICKGEEA
Protein: Polyhomeotic-like protein 1 variant (Q59GP6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
AAAGPAPGAAGGAGSRGRAGRLPPRPRRPRPSRKGRRRGEPAAEAERAPSPAWRLGTPAHEVDAPGEDLGAQPGEKDSWVLSQTEHQPWGPWTTIMETESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNTSTTQQQTTTTQASINLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQGPQMQGSTQKAIPPGASPVSSLSQASSQALAVAQASSGATNQSLNLSQAGGGSGNSIPGSMGPGGGGQAHGGLGQLPSSGMGGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQNVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQPQATTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLSLPPDAAPKPPIPIQSKPPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLAAAVPTSRGMPGTVQSGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKGGATTSSPVVAQVPAAFYMQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVAESPKVMDEKSSLGEKAESVANVNANAPSSELVALTPAPSVPPPTLAMVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGGPLGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEANYARVRRRGPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET
Protein: Phosphomethylpyrimidine synthase, chloroplastic (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Protein PYRIMIDINE REQUIRING) (Thiamine biosynthesis protein ThiC) (Protein THIAMINE C) (O82392)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:18048325, ECO:0000269|PubMed:18332905, ECO:0000269|PubMed:18431481}.
Interaction partners:
- Thiamine biosynthetic bifunctional enzyme TH1
- Bifunctional TH2 protein, mitochondrial
- Thiamine thiazole synthase, chloroplastic
- Thiamine pyrophosphokinase 1
- Thiamine pyrophosphokinase 2
- Hydroxyethylthiazole kinase
- phosphoribosylaminoimidazole carboxylase
- Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic
- 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
Sequence:
MAASVHCTLMSVVCNNKNHSARPKLPNSSLLPGFDVVVQAAATRFKKETTTTRATLTFDPPTTNSERAKQRKHTIDPSSPDFQPIPSFEECFPKSTKEHKEVVHEESGHVLKVPFRRVHLSGGEPAFDNYDTSGPQNVNAHIGLAKLRKEWIDRREKLGTPRYTQMYYAKQGIITEEMLYCATREKLDPEFVRSEVARGRAIIPSNKKHLELEPMIVGRKFLVKVNANIGNSAVASSIEEEVYKVQWATMWGADTIMDLSTGRHIHETREWILRNSAVPVGTVPIYQALEKVDGIAENLNWEVFRETLIEQAEQGVDYFTIHAGVLLRYIPLTAKRLTGIVSRGGSIHAKWCLAYHKENFAYEHWDDILDICNQYDVALSIGDGLRPGSIYDANDTAQFAELLTQGELTRRAWEKDVQVMNEGPGHVPMHKIPENMQKQLEWCNEAPFYTLGPLTTDIAPGYDHITSAIGAANIGALGTALLCYVTPKEHLGLPNRDDVKAGVIAYKIAAHAADLAKQHPHAQAWDDALSKARFEFRWMDQFALSLDPMTAMSFHDETLPADGAKVAHFCSMCGPKFCSMKITEDIRKYAEENGYGSAEEAIRQGMDAMSEEFNIAKKTISGEQHGEVGGEIYLPESYVKAAQK
Protein: Heat shock protein HSP 90-beta (B9EMS3)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MPEEMRQEEEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPTKLDNGKELKIDIIPNVEDRTLTLIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVTVITKHNDDEQYIWESSAGGSFTVKVDSGEPMLRGTKVILHMKENQTEYVEEKRVKEVVKKHSQFIGYPITLFVEKEREKEISDDEEPTSAPAPDEIPPLEGDDDASRMEEVD
Protein: Kinesin light chain (KLC) (P46824)
Organism: Drosophila melanogaster (Fruit fly)
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Kinesin heavy chain
- JNK-interacting protein 1
- JNK-interacting protein 3
- Calsyntenin-1
- FI06030p
- Huntingtin, isoform A
- ADP-ribosylation factor-like protein 8
- Kinesin-like protein unc-104
- LD08195p
Sequence:
MTQMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRRSKAIKEDLDFSEEKNAKP
Protein: Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) (Q9BZQ8)
Organism: Homo sapiens (Human)
Function: Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16949643}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MGGSASSQLDEGKCAYIRGKTEAAIKNFSPYYSRQYSVAFCNHVRTEVEQQRDLTSQFLKTKPPLAPGTILYEAELSQFSEDIKKWKERYVVVKNDYAVESYENKEAYQRGAAPKCRILPAGGKVLTSEDEYNLLSDRHFPDPLASSEKENTQPFVVLPKEFPVYLWQPFFRHGYFCFHEAADQKRFSALLSDCVRHLNHDYMKQMTFEAQAFLEAVQFFRQEKGHYGSWEMITGDEIQILSNLVMEELLPTLQTDLLPKMKGKKNDRKRTWLGLLEEAYTLVQHQVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNYLIGKIKAMVAQPAEKSCLESVQPFLASILEELMGPVSSGFSEVRVLFEKEVNEVSQNFQTTKDSVQLKEHLDRLMNLPLHSVKMEPCYTKVNLLHERLQDLKSRFRFPHIDLVVQRTQNYMQELMENAVFTFEQLLSPHLQGEASKTAVAIEKVKLRVLKQYDYDSSTIRKKIFQEALVQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILHQILLDETLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKPPTGSNQASPARRASAILPGVLGSETLSNEVFQESEEEKQPEVPSSLAKGESLSLPGPSPPPDGTEQVIISRVDDPVVNPVATEDTAGLPGTCSSELEFGGTLEDEEPAQEEPEPITASGSLKALRKLLTASVEVPVDSAPVMEEDTNGESHVPQENEEEEEKEPSQAAAIHPDNCEESEVSEREAQPPCPEAHGEELGGFPEVGSPASPPASGGLTEEPLGPMEGELPGEACTLTAHEGRGGKCTEEGDASQQEGCTLGSDPICLSESQVSEEQEEMGGQSSAAQATASVNAEEIKVARIHECQWVVEDAPNPDVLLSHKDDVKEGEGGQESFPELPSEE
Protein: Meiotically up-regulated gene 168 protein (O94428)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 146 protein
- Meiotically up-regulated gene 165 protein
- Meiotically up-regulated gene 123 protein
- Meiotically up-regulated gene 166 protein
- Uncharacterized membrane protein C16E9.09c
- Phospholipid-transporting ATPase neo1
- Uncharacterized protein C1739.04c
- Uncharacterized membrane protein C17A5.08
Sequence:
MRMDGSDFEDRKVSKPSPVLPFDVSNIGDLSQGVHSPLGISHFDSKNPTPFGRSTKNSVYEYETVTPYSRFKVDKKFGSATSVSPVHTKAEEPGLGLTPMNSADFSNKIASRYRS
Protein: Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1) (P24666)
Organism: Homo sapiens (Human)
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
Subcellular location: Cytoplasm.
Interaction partners:
- P protein
- ATPase GET3
- FAD synthase
- Glutaredoxin-1
- tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
- Transketolase-like protein 2
- Glutaredoxin-2
- tRNA N6-adenosine threonylcarbamoyltransferase
- Glucose-6-phosphate 1-dehydrogenase
- 6-pyruvoyl tetrahydrobiopterin synthase
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
Protein: Interferon alpha-7 (IFN-alpha-7) (Interferon alpha-J) (LeIF J) (Interferon alpha-J1) (IFN-alpha-J1) (P01567)
Organism: Homo sapiens (Human)
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha/beta receptor 1
- Interferon alpha-16
- Interferon alpha-14
- Interferon alpha-10
- Interleukin-2
- Interferon alpha-17
- Interferon alpha/beta receptor 2
- Interferon gamma receptor 1
- Tyrosine-protein kinase JAK2
- Ubiquitin-like protein ISG15
Sequence:
MARSFSLLMVVLVLSYKSICSLGCDLPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFSTNLKKGLRRKD
Protein: Succinate-CoA ligase subunit beta (EC 6.2.1.-) (Q5EBA9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
KKLMSEHGVRVQRFFVASTAKEAQEAAKRLNAKEIVLKAQILAGGRGKGVFDSGLKGGVHLTKDPKVVGQLAQQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSHNGPVLVGSPQGGVDIEEVAASSPELIFKEQIDIFEGIKDSQAQRMAENLGFLGSLKNQAADQIKKLYHLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAARYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKESQVYQAFKLLTSDPKVEAILVNIFGGIVNCAIIANGITKACQELELKVPLVVRLEGTNVQEAQNILKSSGLPITSAVDLEDAAKKAVASVAKK
Protein: Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) (O00482)
Organism: Homo sapiens (Human)
Function: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:28642062}. Chromosome {ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:16289203}.
Interaction partners:
- Nuclear receptor subfamily 0 group B member 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear receptor subfamily 0 group B member 1
- Nuclear receptor coactivator 2
- Catenin beta-1
- Cytochrome P450 7A1
- Nuclear receptor coactivator 3
- 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
- Pancreas/duodenum homeobox protein 1
- Prospero homeobox protein 1
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
Protein: Zinc finger protein AZF1 (Zinc finger protein OZAKGYO) (Zinc-finger protein 1) (Q9SSW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor involved in the inhibition of plant growth under abiotic stress conditions. Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:21852415}.
Interaction partners:
- Cysteine proteinase inhibitor 2
- Zinc finger protein 3
- Transcription factor IIIA
Sequence:
MALETLNSPTATTTARPLLRYREEMEPENLEQWAKRKRTKRQRFDHGHQNQETNKNLPSEEEYLALCLLMLARGSAVQSPPLPPLPSRASPSDHRDYKCTVCGKSFSSYQALGGHKTSHRKPTNTSITSGNQELSNNSHSNSGSVVINVTVNTGNGVSQSGKIHTCSICFKSFASGQALGGHKRCHYDGGNNGNGNGSSSNSVELVAGSDVSDVDNERWSEESAIGGHRGFDLNLPADQVSVTTS
Protein: Lost and found, isoform G (A0A6J3SW69)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLMPTSCGPGPPNDHGPMSLPTSSPSCSKRARIPTRAADDDEPLRRSGTLTQRQSSGSGIPQWLLILIGLLAILAQTPGSQVAAEKSKHYYMQSLCKNHFLQQLYRKIDGAVLWSQNERNLDCIITFQTHSVLQRFMLRFDMLQLDCNDHLLVYDGAHAVATPKIDISCRNTKNTVNALLTRTNFVTLKYVTDGWGTDANGFKLVITSVKDPKHTCKDFTCATREFCIHPDLLCDGINHCGDNSDESVQNLCQNETSSTVFGLDMTWFVLIVVGVLLVLSALIVAVAICVCRRQDENAANQNTALQVHHTADTNGSSKHLHYHGISVGGTLTREHTQLPTSGNWHHPAGPSGYHRTPHNYLKMATKVRPIWCLANSVNXVKIFPTIPPGSARRTSPEPDIPMPTPSALRKRTSGSSRARQHCGRTD
Protein: Neuronal PAS domain-containing protein 4B (E7FFX1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8BGD7, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Zinc finger protein 1041.
- Zinc finger protein 1030.
- PRA1 family protein.
- ATP/GTP-binding protein-like 4.
- Oxysterol-binding protein
- Lysine
- Aryl hydrocarbon receptor nuclear translocator.
- Aryl hydrocarbon receptor nuclear translocator 2
Sequence:
MFSSESRPTVKLPDKWAKKRCFFQLLSSLSTTLKKLCSSSSHCSGFHLIIRPFQRFFGLEKMYRSTKGASKARRDQINAEIRSLKELLPISDADKARLSYLHIMSLACIYTRKSVFFSQAAAGHGMSGSLLSLPELSDLLHTLPGFLLVLTSEGKLLYLSDNVAEHLGHSMVDLVAQSDSVYDIIDPVDHFIMRGNLVPITTPDTDRLFRCRFSTSKFVRRQGSGNKQAIVRARCLPPPYHASPYWTSNPVWVCFCSPLEASMPQLSTSRNPLPTPPAEQSFLLSCFQSQHSRDMRIHTVQDSVSVYLGYDIETLRSRSWYSLIHPRDLSHASAQHCTLLHNGGERQVEMVVQVEAADHSWIWLYIVLQLETGEYPINSHNYVISESEAWSVRQQLHSEQNQLALLYQESRQSSDPLSSPDQVFTPSSSGLSSQSFDFSFITSGRSSSEELPGTSAPSSMTFDPLEGEEIDPQSHGGGHQMWRSAMTIAPEHLSNINLSTVPQSQVAPPPLPPFKAPPKRQRSEEFICTPPYTPRLSGGSFIFNDETLRPSDHSKSAKMRQSITSATNIGPAQPCRKRLYETLPPTPDSPGSDECILMALPEIRGPLYVDVPHLPFHAPPEGLLTPEASPTKKPCLSFFPREDETERERMEISLLAQYISTLAEGFCHNHPQGASAPPHHANSSLAHIDVLMFEEKAVDDIPLPNLPSPSPVPPSPYSSVPSYSQCRSSPVQEEAAVTLIGVNHLCSVQLTHCNRMTEGGLQDGERPDEDMEMMSSQRSSEAPALTPALPCAQSLLEELVTMEPVFGAAVPMTPADRQQDELYQLPHQGGPQMFYQDGTGDHMF
Protein: Protamine-3 (Sperm protamine P3) (Q62100)
Organism: Mus musculus (Mouse)
Function: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Nuclear transition protein 2
- Spermatid nuclear transition protein 1
- Protamine-2
Sequence:
MGSRCAKLSTGHGPAQNTGHSRGHESSMKKLVACVSQDNFSLSSEGEEEEEDEEEEEEEEEEEEEEQIPVKGKLLLLEPEKQESAEDGEAQPSPEPKQTHS
Protein: Concanavalin-A (Con A) (P14894)
Organism: Canavalia gladiata (Sword bean) (Dolichos gladiatus)
Function: Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35 uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08 uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.
Interaction partners:
Sequence:
MAISKKSSLFLPIFTFITMFLMVVNKVSSSTHETNALHFMFNQFSKDQKDLILQGDATTGTDGNLELTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFDATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDANVIRNSTTIDFNAAYNADTIVAVELDTYPNTDIGDPNYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNEIPDIATVV
Protein: Chromobox protein homolog 7 (O95931)
Organism: Homo sapiens (Human)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}.
Interaction partners:
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- Polycomb complex protein BMI-1
- Polycomb group RING finger protein 2
- Histone-lysine N-methyltransferase EZH2
- Polyhomeotic-like protein 2
- Polycomb protein SUZ12
- Chromobox protein homolog 8
- Polyhomeotic-like protein 1
- Polycomb complex protein BMI-1
Sequence:
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
Protein: E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3) (Q86UD3)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16428329}; Multi-pass membrane protein {ECO:0000269|PubMed:16428329}. Early endosome membrane {ECO:0000269|PubMed:16428329}; Multi-pass membrane protein {ECO:0000269|PubMed:16428329}.
Interaction partners:
- Syntaxin-6
- Trans-Golgi network integral membrane protein 2
Sequence:
MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTNQRVILLIPKSVNVPSNQPSLLGLHSVKRNSKETVV