wanglab/gogpt-training-data huggingface dataset:
Protein: Egg cell-secreted protein 1.3 (Q9SJ23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:23180860}. Secreted {ECO:0000269|PubMed:23180860}. Note=Secreted via vesicle exocytose upon sperm arrival, especially in the apical region of the degenerating synergid cell.
Interaction partners:
- At2g21655)
- At4g07515)
- Defensin-like protein 44
- Inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Protein LURE 1.2
- Protein DOWN-REGULATED IN DIF1 11
- ECA1 gametogenesis family protein
- Defensin-like protein 181
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH3
- Transcription factor MYB98
Sequence:
MASNTSFLFVTVTLLLVLNVSSRALPPVADSTNIAARLTGGGLMQCWDALYELKSCTNEIVLFFLNGETKLGYGCCNAVDVITTDCWPAMLTSLGFTLEETNVLRGFCQSPNSGGSSPALSPVKL
Protein: WD repeat-containing protein 18 (Q68EI0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in left-right determination through controlling the correct clustering and migration of dorsal forerunner cells (DFCs) and Kupffer's vesicle formation. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BV38}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Dynein axonemal particle {ECO:0000250|UniProtKB:A0A1L8HX76}.
Interaction partners:
- Testis-expressed protein 10 homolog
- Proline-, glutamic acid- and leucine-rich protein 1
- Nucleolar GTP-binding protein 2
- Notchless protein homolog 1
- Protein SDA1 homolog
- Polynucleotide 5'-hydroxyl-kinase NOL9
- Novel protein similar to human proliferation-associated 2G4 protein
- Proliferation-associated 2G4, b
- Ribosome biogenesis protein wdr12
- Pescadillo
Sequence:
MSAPVEVVLSADSAGQLFNCAVYDPHTGSEFLSYRGGNTSSRSLTILNGEYILGAQLGKNYINVWEIQRKDQLQQKIVCPGIVTCLCASPDGLYVLAGIAEAIYLWEVSTGNLLAILSRHFQDLSCIKFTDDSSHFVSGGKDNLAFIWNLSSVVQLDSSRTPEPRHILSRHSLPITDIHCGLMGPQARVATASLDQTVKVWEISSGEMLLSVLFDVGIMSVTFDPCEYFLFCGGSDGNIFQVSLCSTSLSRDKTFQSDSEGNQVFKGHRNLVTCLSVSMDGTVLLSGSNDETVRMWDVQSKQCIWTINHRGPVTNAAIIPAPANMFLSDSHPAVPLPRFSRHLNPSEQGDGTGTGGMSLRLGANTQEPEGTYLEKAEELYSLMCAVTDKSVFGDGENTKVRVSELEEEVRTLKKINKDLYEFSTQLLTKPN
Protein: Heterogeneous nuclear ribonucleoprotein L (hnRNP L) (F1LQ48)
Organism: Rattus norvegicus (Rat)
Function: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P14866}. Cytoplasm {ECO:0000269|PubMed:18161049}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. {ECO:0000250|UniProtKB:P14866}.
Interaction partners:
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Polypyrimidine tract-binding protein 1
- Heterogeneous nuclear ribonucleoprotein K
- Polypyrimidine tract-binding protein
- Heterogeneous nuclear ribonucleoprotein Q
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoprotein U
- Serine/arginine-rich splicing factor 1
- Heterogeneous nuclear ribonucleoprotein D0
- Heterogeneous nuclear ribonucleoprotein H
Sequence:
MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPPRKFSPVLPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
Protein: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1) (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH-ubiquinone oxidoreductase 51 kDa subunit) (Q91YT0)
Organism: Mus musculus (Mouse)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:38575788}; Matrix side {ECO:0000269|PubMed:38575788}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 6
Sequence:
MLAARHFLGGLVPVRVSVRFSSGTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALRRGDWYKTKEILLKGPDWILGEMKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEDRMQRFAQQHRAWQAAS
Protein: Putative vesicle-associated membrane protein 726 (AtVAMP726) (Q9MAS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}. Early endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
Interaction partners:
- SNAP25 homologous protein SNAP29
- Putative SNAP25 homologous protein SNAP30
- Syntaxin-112
- Novel plant SNARE 13
- Syntaxin-21
- SNAP25 homologous protein SNAP33
- Syntaxin-23
- Syntaxin-related protein KNOLLE
- Syntaxin-125
- Syntaxin-124
Sequence:
MGQQSLIYSFVARGTVILAEYTEFKGNFTSVAAQCLQKLPSSNNKFTYNCDGHTFNYLADNGFTYCVVVIESAGRQIPMAFLERVKEDFNKRYGGGKASTAKANSLNKEFGSKLKEHMQYCADHPEEISKLSKVKAQVTEVKGVMMENIEKVLDRGEKIELLVDKTENLRSQAQDFRTQGTKMKRKLWFENMKIKLIVFGIIVALILIIILSVCHGFKCT
Protein: Polyphenol oxidase (C0LU17)
Organism: Juglans regia (English walnut)
Interaction partners:
Sequence:
MASLLASSSHPRSTNMVAATTTIRTPSFPPCFPRNTQVSKVGKQYHHLTTRVACRATNGDQQNINNGQNPQGKFDRRDVLLGLGGMYGAANLCNDPFALADPVSAPELTLCSEADLPAGALPVNCCPPTSKKIKDFVLPSQNTPLRVRPAAHLVDNDYIAKYNKGIELMKSLPADDPRSFTQQANVHCAYCDGAYTQVGFPDLSLQVHECWLFFPFHRYYVYFFEKILGKLIGDPTFALPFWNWDSPPGMQLPSLYAVSNSAIYDPLRNANHQPPTIIDLDYGETSESTTTTDQVPSNLKIMYRQMVSGAKNPTLFFGSPYRAGDEPDPGAGTIESTPHNNIHLWTGDDTQPNIENMGNFYSAGRDPIFFAHHSNVDRMWTIWKTLGGKRKDITDPDWLNSSFFFYDENADPVRVKVKDCVDNTKLRYVYQDVEIPWLKTKPTPRKSRVKKVAKAFPAGHGGVAQAAETSSVKFPIVLDKVISTVVARPKKSRSKKEKDDEEEVLVIEGIEVERDIPVKFDVFINDEDDAPTGPGINTEFAGSFVSVPQQKQTKKKKTYLRIGISDLLEDLGAEDDDSVVVTLVPRFGKGKAIIGGIKIVLIG
Protein: acetyl-CoA C-acyltransferase (EC 2.3.1.16) (O77466)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MSLQNVCRKGNAFNLLNVARKVQCRALSAAVANPQPKQKNSQNIVLVDGVRTPFLTSGTTYSKLMPHELARHSLLSLLQKKRLDKELIDYIVYGSVIQEVKTSNIAREAALAAGFSNKTPAHTVTMACISSNAAITTGMGLIATNTYDVIVAGGVEFMSDVPIRHSRKMRSLLLKANKAKTLGQRLALLSTFRPDFLAPELPAVAEFSSGETMGHSADRLASAFNVSRSEQDEYALRSHTLAKEAQEKGYFTDLVPFKVSGVDQIVDKDNGIRVSSPESLAKLRPAFVKPDGIVTAANASFLTDGASACIIMTEEKAKQLGLKPKAYLRDFLFVSQDPVNQLLLGPAYGIPKLLKKAGLTLKDIDSWEIHEAFAGQIVANLKALDSDWFCKTYLGLNEKVGTPDLSKWNNWGGSLSIGHPFAATGVRLCMHTANRLVREDGKLGVVAACAAGGQGVAMLIERYPGATAD
Protein: histidine kinase (EC 2.7.13.3) (Q728C6)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MSSPRILIVEDSPSTLRELRRALETELGFTVLTAGSLAEARSVLDHHGPDFFLAVLDLVLPDASDGEIVAAVRAYDIPVVVFTSQFDEATRHSILAQDVIDYFIKNECAIGDLTAAVSRLWRNRNTRILVVDDSTSMRTFLKDELRRYMFQVFEASSGATALRLLERNPDIAVVITDYLMPGMDGLELTRRIRNRWGRETVAVIGVSVQSEMPLTVSFIKNGANDFLTKPFHREELYCRTVMNVEMVERSRSLIELNDLKNRFLGMAAHDLRNPINGIRGFTRMLLDGILGPLNTDQRGILSTVHEASNDMLLLVNDLLDVTVIESGTLELDIVPGPLQELVRERISFAVLAAGAKNIQIIQNIDDIEGCAYDNRRMAQVFDNLLSNAIKFTPADSAVRVALHREGDKAVFSVSDEGPGIKAEERELLFESFRKLSARPTGGESSTGLGLTIVNRIVTAHGGSVWVDDAPASGATFHVSLPLTPSPA
Protein: Protein GFS12 (EC 2.7.10.-) (BEACH domain-containing protein D) (BEACH-domain homolog D) (GREEN FLUORESCENT SEED 12) (F4JY12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act predominantly to suppress BCHC1, which itself is a negative factor in protein storage vacuole (PSV) trafficking regulation and plant effector triggered immunity (ETI). Required for ETI, but not for cell death.
Interaction partners:
- TLC domain-containing protein At5g14285
- Serine/threonine-protein kinase VPS15
- Kinesin-like protein KIN-12C
- Magnesium-chelatase subunit ChlH, chloroplastic
- Ras-related protein RABA1b
- Transducin family protein / WD-40 repeat family protein
- E3 ubiquitin-protein ligase COP1
- WD40 repeat-containing protein HOS15
- Regulatory-associated protein of TOR 1
- Periodic tryptophan protein 2
Sequence:
MRGEDSDLCFDCLDQRINSDFSDQIVFSYGVSDSPLPFGSSAVVKVSDSSEEFSASCSSCESTSSQFILEYLRKDEHGCLAKYVDKFVVKDREGNSNDAVESDECLDCSTSGSQATEDDDTENITCGSVTCEHSGSFSCWRTVAALLPIAQIRKCSASELQKLASSFHYECPEDQILASLHRLIDGKSSGQATHSFLCLLLGLPLLEEKSKLRCLRHPNLSPVLGLLTSSDCLVSVLPKAPYTLENILYYSPSAIKSEWHRNFIIYQLLSALAHLHGLKVSHGDIRPSNILLSDSLWSWLTIYSKPDLGSVDANSSASRRRWCVEGCYSYGLYADLKISSHLDWQTHFDKWWKGELSNFEYLLVLNKLAGRRWGDHTFHPVMPWVIDFSKKPENDSDSGWRDLRKSKWRLAKGDEQLDFTYSTFEFPHHVSDECLSELAVCSYKARRLPLSVLRKAVRSVYEPNEYPSDMQRLYDWTPDECIPEFYCDPRIFCSLHPSMSDLAVPPWASSPDEFIRLHRDALESPHVSSLIHHWIDITFGYKMSGHAAITAKNVMLSSSEPTVPRSVGRRQLFFRPHPVRLGFSREKEQSRNELEMHTFHGFGVDNKRSVILLADEYLEETEEASAFSDHATHLCPKYHLRENLVESPLHVSYSENTKKVNTSLPGTSKNKGLSSRISLNYLLEHMEVRDEASTELQELLQWRQDFCTGNISKDIAGDIFSIGCVLAELYLMKPLFNSVSLATYLEGGDLPELIKELPPPTQVIVEACIEQDWRRRPSAKSLLDSPYFSATVRSAHLFAAPLQLLAKGQTRLCYAASFAKQGVLKVMGTFVAEMCAVYCLPLVTTPLSEDECELAYVLLKEFTKSLTPMAVQRLVLPSIQKILLTTGYSHLKVSLLQDSFVRELWNQIGKRVYLEMIHPLVISNLYNSPDKISASAASVLLIGSSEELGAPVTVHQTILPLISYFGKGICTDGIDVLVRIGRLLGVNFIVKQMLPLLEHVVCFCIDLSSMKKPEPVHSWCSLALSDCLITLDGLVALISDELLIHELTKGRLCLHVRVLMQKNLELRVLQFAATSLMSICQRIGQEMTALHVLPQLKELFDEFAFSEKSTDASDSLSWKIRTAEQKFHPESPIKSRMDLVLLLYPSFASLLGMEKLRQGCPTWLLLEQYLLKHHNWKWEYTGRSSRYNMEARPVLKQGPASKHTPKVLLNGSGRSVPQSQGLRNSNHLKLHIHVPVEGQEAVLNPLVHEPWSWFPSPVTCWDGLDIGRFGNPKDENRWKIRASVLSSARAHHGALRSLVVSEDECTVFTSGIDPGFKGSVQKWELASLSCVSSYHAHEEVVNDIGILSSTGKVASCDGTIHVWNSQTGKLISLFSESPSDQDQASSDPSSKNNSNPCNRHASHGLSSGIFDENLYTCMHYLEYMDQLIVGTGFGALRFIDLARGQKLELWGGEAIESGFTSLVSALCSGGSQTKHGDGASVSPSWIAAGFSSGQCRLFDLRENGFISSWRAHDGYVTKLVAPESHLLVSSSLDKTLRIWDLRKSWTPQPFVVKGHNDGVSGFSIWGKDVISISRNNIGIFSLAKSQDEEEQQQQRIIPQKLYMAEKGGRVKSDLSTICVLPFSRLFIVGAHDGHLRICC
Protein: FERM and PDZ domain containing 4 (A0A8I6GKT4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILFTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGTENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKAVEMTDSTLCPKEHRHLYIDNTYSSDELSQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTLGYERMLDENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVSEINQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHENKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPTVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKTPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLAEGEGKCPLSGNVPGKKQQGTKIAETEEDTKGKVGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGVEAPAMKAFPRGPGLGNREAEGKEDGTMEGEADDASGLGQGERFLSDMACVASAKDLDNPEDTDSPTCDHATKLPEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHLIPDASGKGGSYISPEERVAGHPNHGATFKELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTALTEPGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGNQAFGEAVSWRPADLRGGSLRTPPSQRALRHSSSILSGPVGLETFQEGTKGVVSLKYPGITEAQEASSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPMSHKDSKVYRTLPLRKLESSNWRCRGPFSYCFLNQGQDEDGDEDEEGEATLQVSCLYRPHITQGMPETSNSSLAVGLQKQGEELSRGTVLKDWTEDPDGPDDLDFSSLAFDARIARINALKANTYGMPDGFLEAQNDANELLCLVRATKAKREESRPEAYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPEEMLLAMSSSFQVLCCLTEACMRLVKVVNSETQRQEIVEKIDEVVINYICLLKAAEAATGKTTGDPSIGLSMRHSTTMAALVSTLTRSLKMLLNK
Protein: Myelin protein zero-like protein 1 (Protein zero-related) (O95297)
Organism: Homo sapiens (Human)
Function: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Peripheral myelin protein 22
- Tyrosine-protein phosphatase non-receptor type 11
- mRNA cap guanine-N
- Gap junction beta-1 protein
- Myelin basic protein
- Ganglioside-induced differentiation-associated protein 1
- E3 SUMO-protein ligase EGR2
- Tyrosine-protein phosphatase non-receptor type substrate 1
- Myelin-associated glycoprotein
- Periaxin
Sequence:
MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN
Protein: At2g16030 (A2RVU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MERNVEKMLKRVSIVFLSIGTVLMVIMILQTPKTCISPEAPSKPHTHFPRSTCDSSPRQHLPLPKKNARIWSSGAWKSRLYSFSTYFLRFRDLGFIQNHTKALCLSAGAGHALMALSQIGLSDVTAVELVDSIPLVKRADPHNLPFFDGVFDFAFTAHLAEALFPWQFVEEMERTVRRGGFCVVSVDECGGDDVRDIARLFHNSKVVDVANVTLEGSKKTSILFKVQDSLS
Protein: Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (P46656)
Organism: Mus musculus (Mouse)
Function: Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P10109}.
Interaction partners:
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- Cysteine desulfurase
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- LYR motif-containing protein 4
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- steroid 11beta-monooxygenase
Sequence:
MAAAPGARLLRAACASVPFRGLDRCRLLVCGTGAGTAISPWTPSPRLHAEAGPGRPLSVSARARSSSEDKITVHFKNRDGETLTTKGKIGDSLLDVVIENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAFGLTDRSRLGCQVCLTKAMDNMTVRVPEAVADVRQSVDMSKNS
Protein: POU domain, class 4, transcription factor 2 (Brain-specific homeobox/POU domain protein 3B) (Brain-3B) (Brn-3B) (Brn-3.2) (G3V7L5)
Organism: Rattus norvegicus (Rat)
Function: Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:18368538}. Nucleus speckle {ECO:0000250|UniProtKB:Q12837}. Cytoplasm {ECO:0000250|UniProtKB:Q63934}.
Interaction partners:
- Insulin gene enhancer protein ISL-1
- Atonal bHLH transcription factor 7
- Visual system homeobox 2
- Cellular tumor antigen p53
- Melanopsin
Sequence:
MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGSGGGGGGGGGGGGGGRSSSSSSSGSGGGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
Protein: Probable FMN/FAD exporter YeeO (P76352)
Organism: Escherichia coli (strain K12)
Function: A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin; intracellular concentrations of FMN and riboflavin rise, possibly to compensate for increased secretion. Increased overexpression causes slight cell elongation.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLRHILTAKNLLSNPIFKFPNCLPFLSTVCCICRQFVGENLCSFADSPSLFEMWFHFLQLRSALNISSALRQVVHGTRWHAKRKSYKVLFWREITPLAVPIFMENACVLLMGVLSTFLVSWLGKDAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARVATRQSLVIMTLFAVLLATLIHHFGEQIIDFVAGDATTEVKALALTYLELTVLSYPAAAITLIGSGALRGAGNTKIPLLINGSLNILNIIISGILIYGLFSWPGLGFVGAGLGLTISRYIGAVAILWVLAIGFNPALRISLKSYFKPLNFSIIWEVMGIGIPASVESVLFTSGRLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGSALGSASTIITGRRLGVGQIAQAEIQLRHVFWLSTLGLTAIAWLTAPFAGVMASFYTQDPQVKHVVVILIWLNALFMPIWSASWVLPAGFKGARDARYAMWVSMLSMWGCRVVVGYVLGIMLGWGVVGVWMGMFADWAVRAVLFYWRMVTGRWLWKYPRPEPQKCEKKPVVSE
Protein: Non-POU domain-containing octamer-binding protein (C9IZL7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQSNKTFNLEKQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPANGQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDR
Protein: Berberine bridge enzyme-like 10 (AtBBE-like 10) (EC 1.1.1.-) (Q9SA87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:O64743}.
Interaction partners:
- Peroxidase 71
- Peroxidase 62
- FAD-dependent oxidoreductase domain-containing protein 1
- NAD
- glucan endo-1,3-beta-D-glucosidase
- Peptide methionine sulfoxide reductase B9
- Peptide methionine sulfoxide reductase B8
- Pectinesterase inhibitor 7
- Pectinesterase inhibitor 11
- Peroxidase 45
Sequence:
MEKLLVISLLLLISTSVTTSQSVTDPIAFLRCLDRQPTDPTSPNSAVAYIPTNSSFTTVLRSRIPNLRFDKPTTPKPISVVAAATWTHIQAAVGCARELSLQVRIRSGGHDFEGLSYTSTVPFFVLDMFGFKTVDVNLTERTAWVDSGATLGELYYRISEKSNVLGFPAGLSTTLGVGGHFSGGGYGNLMRKYGLSVDNVFGSGIVDSNGNIFTDRVSMGEDRFWAIRGGGAASYGVVLGYKIQLVPVPEKVTVFKVGKTVGEGAVDLIMKWQSFAHSTDRNLFVRLTLTLVNGTKPGENTVLATFIGMYLGRSDKLLTVMNRDFPELKLKKTDCTEMRWIDSVLFWDDYPVGTPTSVLLNPLVAKKLFMKRKSDYVKRLISRTDLGLILKKLVEVEKVKMNWNPYGGRMGEIPSSRTPFPHRAGNLFNIEYIIDWSEAGDNVEKKYLALANEFYRFMTPYVSSNPREAFLNYRDLDIGSSVKSTYQEGKIYGAKYFKENFERLVDIKTTIDAENFWKNEQSIPVRR