wanglab/gogpt-training-data huggingface dataset:
Protein: Carbohydrate-binding-like fold (Q9LZQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
- At1g13730
- Nicalin
- protein-synthesizing GTPase
- Nucleolar GTP-binding protein 1
- Guanylate-binding family protein
- Universal stress protein PHOS32
- Large ribosomal subunit protein uL4z
- Nuclear transport factor 2
- Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha 1
- AT5g22320/MWD9_11
Sequence:
MAASRKICHSLIVFLIAISTVYGVSADSIKGCGGFVEASSSLVRSRKGSDGKLDFSHITVELQTVDGLVKDSTQCAPNGYYFIPVYDKGSFILKINGPDGWSWNPDKVTVVVDDSSCNNNDDINFHFTGFTLSGKVLGAVGGESCLIKNGGPADVNVELLSSDGSEDPVASVLTSSDGSYLFKNIIPGTYNIRASHPELQVEVRGSTEVELGFANGMVDDIFFVLGYDLKGSVVAQGNPILGVHIYLHSDDVSMVDCPQGSGDAAGERKSLCHAVSDAEGIFSFKSIPCGKYELVPHYKGENTVFDVSPPVMPVSVEHQHVTVPQKFQVTGFSIGGRVVDGNSVGVEGVKILVDGSLRSVTDKEGYYKLDQPAKLVVTQPLLVNFLRLLESRVKNMARFLKVTSNQYTIDAVKEHYKFDKLKKFMVLPNMASLPDINAVSYDICGVVRMFGSRHKAKVALTHGPTNVKPQMKLTDETGAFCFEVPPGEYRLSALAATPKGASELLFLPAYVDVAVKSPLLNIEFSQARVNVHGSVTCKEKCGPSVSVVLVGAAGDRDKKTVVLTDESSQFLFSDILPGKYRVEVKSISPEAASDEDSWCWDRSSIDVNVGTEDIKGIEFVQKGYWINIISTHEVDARIAHPDGSPTSLKIKKGSQKICIESPGGHELQLSDSCMSFGSNSIKIDVSNPQPIHLKAEKYLLKGLINVESSSTIESELQENFIVDIQDKKGNVINTIAAKLASDGSGVYEYYTWASLGEKISFVPQDSRGNVEKKMLFYPKEIHAVVSKDGCQASVSPFTGRLGLYIQGSVSPPLPGVNIKIFAAKDSLISSLKKGEIAIETSTLSAGSFVAGPLYDDIPYATEASKPGYHIKRLGPYSFSCQKLGQISVRVNSKDNAETSIPPLLLSLSGDHGYRNNSISGAGGLFVFDSLFPGNFYLRPLLKEYSFKPSTLAIELNSGESSEAVFEATRVAYSAMGRVALLSGQPQEGVAIEARSDSKGYYEETTSDINGNYRLRGLHPDTAYVIKVSKKIGSANNQIERASPESVSLQIGYEDINGLDFLVFEQPETTILTCHVEGKQNEDLNSNLLVEIKSAIDKSKIENVFPLPLSNFFQVKGLPKGKHLVQLKSSRPLISHKVESEIIEVDFETNAQIHIGPLRYSIVADHQSQEVTPAAILPLVIGVSAIALFLSIPRLKDIYQATVGISSPGFTTSAKREPRKAVARKKTF
Protein: Flotillin (J3QLD9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004543}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004543}. Membrane {ECO:0000256|RuleBase:RU366054}. Endosome {ECO:0000256|RuleBase:RU366054}.
Interaction partners:
Sequence:
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRLSLEVMTILCRCENIETSEGVPLFVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
Protein: Large ribosomal subunit protein uL1 (60S ribosomal protein L10a-2) (Q9VTP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 40S ribosomal protein S27
- 60S ribosomal protein L27
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL6
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein uL29
- FI01658p
- Large ribosomal subunit protein uL22
Sequence:
MASKVSRDTLYEGVNGLLEASAKKKRGFLETVELQIGLKNYDPQKDKRFSGTVKLKHIPRPKMKVCILGDQQHCDEAKANNVDFMDAEALKKLNKNKKLVKKLAKSYDAFLASESLIKQIPRLLGPGLNKAGKFPALLSHQESMIGKIEEVKSTIKFQMKKVLCLSVAVGHVGMKSDELAQNVNLSINFLVSLLKKNWQNVRSLHVKSSMGPPQRLY
Protein: SNARE protein (Q8I346)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046278}; Lipid-anchor {ECO:0000256|ARBA:ARBA00046278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00046278}.
Interaction partners:
- Syntaxin, Qa-SNARE family
- Protein transport protein BOS1, putative
- SNARE protein, putative
- BET1-like protein, putative
- Protein transport protein SEC22
- Syntaxin, Qa-SNARE family
- Sec1 family protein, putative
- Vacuolar protein sorting-associated protein 33, putative
- Vacuolar protein sorting-associated protein 16, putative
- Alpha-soluble NSF attachment protein, putative
Sequence:
MNLLAIFLTKYVEDVIFLCNATDLNSYSFIKKKAFKEAAFFVARTIPSRIEYNTKEIITHENNTVFAFKYEDNICPIVIATDDYPERVAFYMINEIYRDFISTIPKEEWSSVKQDNKISFNLYTYLTKYKDPLNCDAITQTNIKINENIEKVRVTMDALIRNRENLDVLVDKSKDLSSTTKQLFKQSKKLKKKQCCSIM
Protein: Macrophage metalloelastase (MME) (EC 3.4.24.65) (Matrix metalloproteinase-12) (MMP-12) (P34960)
Organism: Mus musculus (Mouse)
Function: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Metalloproteinase inhibitor 1
- Elastin
- Collagen alpha-1
- Metalloproteinase inhibitor 2
- Neutrophil elastase
- Metalloproteinase inhibitor 3
- Macrosialin
- Cathepsin K
- Matrilysin
- Neutrophil collagenase
Sequence:
MSCTLLKGVCTMKFLMMIVFLQVSACGAAPMNDSEFAEWYLSRFYDYGKDRIPMTKTKTNRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKREDVDYIFQKAFQVWSDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLYGAPVKPPSLTKPSSPPSTFCHQSLSFDAVTTVGEKIFFFKDWFFWWKLPGSPATNITSISSIWPSIPSGIQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYPRSIYSLGFSASVKKVDAAVFDPLRQKVYFFVDKHYWRYDVRQELMDPAYPKLISTHFPGIKPKIDAVLYFKRHYYIFQGAYQLEYDPLFRRVTKTLKSTSWFGC
Protein: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (Q9WUM5)
Organism: Mus musculus (Mouse)
Function: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03222}.
Interaction partners:
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Isocitrate dehydrogenase subunit
Sequence:
MTATVVAAAATATMVSSSSGLAAARLLSRTFLLQQNGIRHGSYTASRKHIYIDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQKHLGLPVFNTVKEAKEKTGATASVIYVPPPFAAAAINEAIDAEIPLVVCITEGIPQQDMVRVKHRLTRQGTTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCIGIGGDPFNGTDFIDCLEVFLNDPATEGIILIGEIGGHAEENAAAFLKEHNSGPKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML
Protein: 60S ribosomal protein L23 (Q8IE82)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 40S ribosomal protein S16, putative
- 60S ribosomal protein L34
- 40S ribosomal protein S26
- Large ribosomal subunit protein eL43
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L7a
- 60S ribosomal protein L38
- Small ribosomal subunit protein eS1
- 60S ribosomal protein L19
- 40S ribosomal protein S11
Sequence:
MTQVEKKKKNVKNVNKHKIIHKRVIKKGNRKYTNGNTKVKYRKQVVKKTINKNVSKKKLLKENVDKDEKKKKMKISIRFKKPKTLIYARNPKCPRIVKSCHSKTLDKYGLIKYPLTSEKAMKKIEEINTLVFMCDKRANKKNIKKSVKNLFGIECDKVNVLNTLNGDKKAYVRLSGEHDALEVANKIGIL
Protein: Loricrin (P23490)
Organism: Homo sapiens (Human)
Function: Major keratinocyte cell envelope protein.
Subcellular location: Cytoplasm. Nucleus, nucleoplasm.
Interaction partners:
- Involucrin
- Filaggrin-2
- Filaggrin
- Trichohyalin
- Keratin, type II cytoskeletal 1
- Keratin, type I cytoskeletal 10
- Protein-glutamine gamma-glutamyltransferase K
- Corneodesmosin
- Small proline-rich protein 3
- Cornifin-B
Sequence:
MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 5 (Small integral membrane protein 4) (Small nucleolar RNA host gene 8) (Q8C1Q6)
Organism: Mus musculus (Mouse)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand. Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:35977508}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MFSRAQVRRALQRVPGKQRFGIYRFLPFFFVLGGAMEWIMIKVRVGQETFYDVYRRKASERQYQRRLEDTSETNLHKLIK
Protein: Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) (Q7TPR4)
Organism: Mus musculus (Mouse)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23100251}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11114196}. Cell membrane {ECO:0000250|UniProtKB:P12814}. Cell junction {ECO:0000250|UniProtKB:Q9Z1P2}. Cell projection, ruffle {ECO:0000269|PubMed:17298598}. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle (PubMed:11114196). Colocalizes with PSD in membrane ruffles and central reticular structures (PubMed:17298598). {ECO:0000269|PubMed:11114196, ECO:0000269|PubMed:17298598}.
Interaction partners:
- Alpha-actinin-4
- Vinculin
- Actin, cytoplasmic 2
- Zyxin
- Actin, cytoplasmic 1
- Catenin alpha-1
- Beta-parvin
- Catenin alpha-2
- Catenin alpha-3
- MICAL-like protein 2
Sequence:
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL
Protein: Homocysteine/cysteine synthase (EC 2.5.1.47) (EC 2.5.1.49) (O-acetylserine/O-acetylhomoserine sulfhydrylase) (OAS-OAH SHLase) (OAS-OAH sulfhydrylase) (P06106)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Also catalyzes the conversion of O-acetylserine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, it seems that in S.cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS. It therefore has no metabolic role in cysteine biosynthesis and may only have a regulatory role controlling OAS levels.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11914276}.
Interaction partners:
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Putative mitochondrial cysteine synthase
- Sulfite reductase flavoprotein component
- Cystathionine beta-synthase
- Sulfite reductase subunit beta
- Orotidine 5'-phosphate decarboxylase
- Adenosylhomocysteinase
- Homoserine O-acetyltransferase
- Cystathionine gamma-lyase
- Cystathionine gamma-synthase
Sequence:
MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP
Protein: Isoleucine--tRNA ligase, chloroplastic/mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) (Protein OVULE ABORTION 2) (Q8RXK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16251277}. Mitochondrion {ECO:0000269|PubMed:16251277}.
Interaction partners:
- Proline--tRNA ligase, cytoplasmic
- Proline--tRNA ligase, chloroplastic/mitochondrial
- Leucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, chloroplastic/mitochondrial
- Glutamine--tRNA ligase, cytoplasmic
- Arginine--tRNA ligase, chloroplastic/mitochondrial
- Arginine--tRNA ligase, cytoplasmic
- Glutamate--tRNA ligase, chloroplastic/mitochondrial
- Methionine--tRNA ligase, chloroplastic/mitochondrial
- Glutamate--tRNA ligase, cytoplasmic
Sequence:
MSSFFKSFAGNPREAAAMAMVQSSSYRVLSGKSCSNLRRNTPLDSFLAKGRSSVKAFSFLYVSRFSTEPNNEFGHSSKRRSRGPVMAAKKASEGEKQEDGKYKQTVDLPKTGFGMRANSLTREPELQKLWEENQVFKRVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQEVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPEGHISKSIYAIFKLVGGAKTSLLDEFIPNIYLAVWTTTPWTMPANAAVAVNAKLQYSVVEVQSFSEDESTVTSNKKKIPGKVLKNQQKLFVIVATDLVPALEAKWGVKLSISKTFLGSDLENCRYTHPIDNRDCPVVIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLGEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHVKTKEPLMNEETINHVKSIISQKGSDAWWYMSVEDLLPEKYRDKAADYEKGTDTMDVWFDSGSSWAGVLGKREGLSFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEGGKNSKDAPAYGADVMRLWVSSVDYTGDVLIGPQILRQMSDIYRKLRGTLRYLLGNLHDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFEYRNEDGSAAEFVFELKWPTLNEQWLSFPAEDVLFWQRLLELRTEVNKVLELARNEKMIGSSLEAKVYLHTADAGMAAKLLEMSEAKNEADTLQRIFITSQVEVLSSMEKEMISSVQHTGEYVEGENKVWIGVSRAEGSKCERCWNYSGQVGSFSDHPTLCGRCFSVIVANPPEPAVAAVNSLA
Protein: Glutaredoxin domain-containing cysteine-rich protein 2 (GRXCR1-like protein) (Glutaredoxin domain-containing cysteine-rich protein 1-like protein) (Q3TYR5)
Organism: Mus musculus (Mouse)
Function: Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.
Subcellular location: Cell projection, stereocilium {ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:35752427, ECO:0000269|Ref.3}. Note=Concentrated at the basal taper region of stereocilia in early postnatal development (PubMed:30380417). In adult hair cells, concentrated at the basal region but also detected along the stereocilium shaft (PubMed:30380417). {ECO:0000269|PubMed:30380417}.
Interaction partners:
- Taperin
- Chloride intracellular channel protein 5
- Rho family-interacting cell polarization regulator 2
- Unconventional myosin-VIIa
- Glutaredoxin domain-containing cysteine-rich protein 1
- Twinfilin-1
- Unconventional myosin-Ic
- Xin actin-binding repeat-containing protein 2
- Radixin
- Plastin-1
Sequence:
MEDSEKKLNQKSDDKPRKVRFKISSSYSGRVLKQVFEDGQELESPKEEYPHSFLQEALEPMDGVYGSGEVPKPQPYSPKLTAQRISVFRDSGAYTLAGSQPLFNDYKANDHKPPPIIDFGKIIIYTNNLKIIRTPMDKRDFMRKILQKEDVAEEASLMITGENDGDREQGCPLPERNGSPLPESERTFLHSQHTQDGLVPEDCLHCQGSGIATCSLCHGSKFSMLANRFKESYRALRCPACNENGLQPCRICSP
Protein: BPI fold-containing family B member 3 (Ligand-binding protein RYA3) (Long palate, lung and nasal epithelium carcinoma-associated protein 3) (P59826)
Organism: Homo sapiens (Human)
Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).
Subcellular location: Secreted {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12837268}. Note=According to PubMed:12837268, it is cytoplasmic.
Interaction partners:
Sequence:
MLALWSLLLLWGLATPCQELLETVGTLARIDKDELGKAIQNSLVGEPILQNVLGSVTAVNRGLLGSGGLLGGGGLLGHGGVFGVVEELSGLKIEELTLPKVLLKLLPGFGVQLSLHTKVGMHCSGPLGGLLQLAAEVNVTSRVALAVSSRGTPILILKRCSTLLGHISLFSGLLPTPLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGAVLGLVSLGALGSVEFSLATLPLISNQYIELDINPIVKSVAGDIIDFPKSRAPAKVPPKKDHTSQVMVPLYLFNTTFGLLQTNGALDMDITPELVPSDVPLTTTDLAALLPEALGKLPLHQQLLLFLRVREAPTVTLHNKKALVSLPANIHVLFYVPKGTPESLFELNSVMTVRAQLAPSATKLHISLSLERLSVKVASSFTHAFDGSRLEEWLSHVVGAVYAPKLNVALDVGIPLPKVLNINFSNSVLEIVENAVVLTVAS
Protein: Iron-sulfur cluster-binding protein (Q72AR1)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Homocysteine biosynthesis enzyme sulfur-incorporation domain-containing protein
- Pyridine nucleotide-disulfide oxidoreductase
- Methionine synthase
- Adenosylhomocysteinase
- Ech hydrogenase, subunit EchA, putative
- NAD
- Homoserine dehydrogenase
- Aspartate-semialdehyde dehydrogenase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- cysteine-S-conjugate beta-lyase
Sequence:
MSAQPQKPYRKNVHLTFPPEISGNPLVCNLTRLFDLTFNILKAQITPRKEGYLTLELMGDEANCTKAMEYLREHDVVVTPVAQRISRDEEGCMHCGMCTAICPTSALRMNLENRTVTFELDRCTACGLCTRVCPVAAMHVELENGHY
Protein: Nucleotide-binding oligomerization domain-containing protein 1 (A0A060X8V7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
Interaction partners:
- Receptor-interacting serine/threonine-protein kinase 2
- CARD domain-containing protein
- Protein kinase domain-containing protein
- Protein kinase domain-containing protein
- Protein kinase domain-containing protein
- SGS domain-containing protein
- Uncharacterized protein
- Autophagy-related protein 16 domain-containing protein
- Autophagy-related protein 16 domain-containing protein
- Uncharacterized protein
Sequence:
MDSSAEEARAGLTGHVSTVQMLTLHRELLVSQVKSTQCIMDNLLQSGFLCIEDAEIIQRAATKTDQVRKILELVQRKGVQACEYFLYILYKVYDAYIDLQPWLKEINYQPPDFVRDIPVKNTDPISRYCEKLRHELGRDTRFIASYAQQEETLLEELYTDTLMELLNDRNESLGHLEGLEQLLGEQGVFNSQAETVLVTGDAGVGKSILLQKLQRLWSKRELEQTDAMFFFKFRCRMFSTFKETDEISLRDLLFKYNCYPDQDADNEVFSYILRFPEKVLFTFDGYDEIQADLDLVNVPEVVSPEERTHPLLVLINLLCGKLLNGSRKVLTARTGTDVQSRVIRKRVALRGFSPAQLQTYTNVHFKEQEHRNLVSVQLDASPHLCGLCSIPLFCWIVFRSFKHLHSVYDDFELPEACVTLTNIFLLLSEVFFSRGAAPPPVLLKRNTRCPADTFRAGLRPLTAFSKLALLGMERGGFVFDQEEVASCGLTDDDLKVGFLRPVSCYDACENPSTFEFLHLTLQSFLAAFSLVLDEQASVGNILKFFTECSRRGNTSCLSCVVHCIGGSSKPRGKDPFKTNEHLQYANLFLCGLLSKANASLLEHMVPAALLKRKRAVLKSYLSTSVRSHLRGLPLYSTEQEGSKVHVLPNFLWMLRCIFETGSKEVAQLTAKGITADYIKLGYCNVFSGDCSALNFVLQHRRKRLGLDMDNNNISDYGVKQLRPSFSKMTVVRLCVNQISDSSVEVLAEELIKHRVVEVLGLYNNHITDIGAKLIAHIIEECPKLRVVKLGSNKFTSMGGKYLASAIQKSTSIFDVGMWGNSIGDEGARAFAEALRNHPSLTNLSLSANGITSEGGRSLAEALKGNTMLRIFWLVQNELSDDVAPDLAELIRSNTGLSHLWLINNQLTVGGIRQLSEALSHNTSLKEISLKGNCLSEEEEKLFEAEGRLRFH
Protein: Thymine DNA glycosylase (F5H0I7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTET
Protein: RNAP inhibitory protein (RIP) (ORF145) (Q3V4R7)
Organism: Acidianus two-tailed virus (ATV)
Function: Plays a role in the inhibition of global transcription by interacting with the RNA polymerase (RNAP) clamp, locking it in a fixed position and inhibiting the formation and/or stability of the pre-initiation complex (PIC). Also overlaps with the transcription factor B binding site; overall RIP probably interferes with DNA loading onto RNAP but does not displace DNA once it is loaded. May play a role in virus particle assembly, possibly by dissociating active RNAP from the virus genome (Probable).
Subcellular location: Virion.
Interaction partners:
Sequence:
MKNMLHPQKYETHVLDDLMEFYEGVIGYPEIDLRLAGEEAWLKGVNPELAEAVKKIIKTIRRYLEGSPYDGSEKPIPRYIIAEIFSQIAPEVQLLVNALDTEGKYGFLKHIKKLNLNSLAMLSKNYNENDKLWKELENEGYVYLE
Protein: Ribosomal protein L30 ferredoxin-like fold domain-containing protein (Q38ED8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Large ribosomal subunit protein uL3m
- Uncharacterized protein
- 50S ribosomal protein L16, putative
- 50S ribosomal protein L17, putative
- Mitochondrial RNA binding complex 1 subunit
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MMRRMWVPTFSAQQQHLHHAMGLKMLTYASTPSGSGVTSAASNEEMNLHDAAAIAPGPYRRVGNIFIVHCDDHPFKHSWEVNRMLRELRLEFKGQTTIVPDIPQVRKRIWRVRHIVKVDVLDLDEAKALIGVPEHISFTDLASQLPPSFGRVKAVPSPVIRSKMNFMKLRRMRLRDVLHRDALELRLLELKRSAMKNAEQQKHAQKDERTDNKEGEKC
Protein: Benzoate--CoA ligase, peroxisomal (EC 6.2.1.25) (Acyl-activating enzyme 20) (Protein BENZOYLOXYGLUCOSINOLATE 1) (Q9SS01)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Benzoate--CoA ligase involved in benzoyloxyglucosinolate biosynthesis in seeds. Glucosinolates are secondary metabolites involved in pathogen and insect defense of cruciferous plants.
Subcellular location: Peroxisome {ECO:0000305}.
Interaction partners:
- Cytochrome P450 83A1
- Serine carboxypeptidase-like 5
- Serine carboxypeptidase-like 17
- Pentatricopeptide repeat-containing protein At1g05670
- Methylthioalkylmalate synthase 3, chloroplastic
- Methylthioalkylmalate synthase 1, chloroplastic
- Branched-chain-amino-acid aminotransferase 3, chloroplastic
- Aldehyde oxidase 4
- Putative acyl-activating enzyme 19
- Probable sodium/metabolite cotransporter BASS5, chloroplastic
Sequence:
MDDLALCEANNVPLTPMTFLKRASECYPNRTSIIYGKTRFTWPQTYDRCCRLAASLISLNISKNDVVSVMAPNTPALYEMHFAVPMAGAVLNPINTRLDATSIAAILRHAKPKILFLDRSFEALARESLHLLSSEDSNLNLPVIFIHENDFPKRASFEELDYECLIQRGEPTPSMVARMFRIQDEHDPISLNYTSGTTADPKGVVISHRGAYLCTLSAIIGWEMGTCPVYLWTLPMFHCNGWTFTWGTAARGGTSVCMRHVTAPEIYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGPVHVLTGGSPPPAALVKKVQRLGFQVMHAYGQTEATGPILFCEWQDEWNRLPENQQMELKARQGISILGLADVDVKNKETQKSAPRDGKTMGEILIKGSSIMKGYLKNPKATFEAFKHGWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLEKSETTIKEDRVDKFQTRERNLIEYCRENLPHFMCPRKVVFLEELPKNGNGKILKPKLRDIAKGLVVEDEINVIAKEVKRPVGHFISRL
Protein: Ski oncogene (Proto-oncogene c-Ski) (Q9YI02)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEAPSSFQPHPGLQQTLKQFHLSSMSSLGGPAAFSARWQQDMLFKKDGKSAEVLVNLPAQTPPVMPGPLFIPSDRSTERCETVLERETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFSAPSCGLITQTDAERLCNALIYGGTFPPHADKELSCSIELERTEKSFKVYHECFGKCKGLFVPELYTSPNAACIQCLDCRLMFPTHKFVVHSHKRLENRTCHWGFDSSNWRAYILLDQDYSEKEENSTLQQLLTELKGKFEMGNKHKTSYKAYSPIPSKKLKHDRSRSPSADREKPADWLQSLAASANKDLKQLQFKQRPSAFRPWSPRVPSAERETPNHKYERSLAKTQDNLAVPNVSLPIAAFKNNEQPAHRFSQPTESHNTGKTESSRPRKRWPSAERQSQPATKTSLCTPIKQRLQENHDSDEEIQVDNCAEVAVSRSLMSPPFTNGVGVMTLSPHSSAEVHDGRARLAAGHCSELELLKQTLSSDLSSKEAREKFLQEIIRMRVKQEEKLAAALQAKRSLQQELEFVRVTKKGRLREAIEAKRNLRKEIERLRVECEKKVRDASESCDRLKRDLDRERRTRVCDKNCEAGRLRAKYSSQIEDLQMKLQQAEVDREQLREDLLKERDARQNLERVVKELQEQLGHKAETEANTQPTKGDQDIS