wanglab/gogpt-training-data huggingface dataset:
Protein: Spectrin beta chain (Q00963)
Organism: Drosophila melanogaster (Fruit fly)
Function: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Interaction partners:
- Spectrin alpha chain
- Ankyrin, isoform B
- LD44914p
- Uncharacterized protein, isoform A
- GH08048p
- HotDog ACOT-type domain-containing protein
- Ankyrin 2, isoform U
Sequence:
MTTDISIVRWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVDVGASHDDSERGGTPGAGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRSQTLPATSQKDEPKRRSFFTLKKK
Protein: Meiotically up-regulated gene 157 protein (Q10449)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MKYWQAILFFLFGIAFANNLNIPWKACPNYKTYSGRRHYPATGPLRLPFQRPATSCRTFHSKSVEQTIEDVKEQLEDEDLARLFENCMPNTLDTTIRWHAADSHNPQTLVITGDIPAEWIRDSANQLLPYLPLAKSDSPLATLILGAIQTQAEMLIQFPYCNAFQPPKQSFLSGNDNGQSDRVTPAYDPAVVFECKYELDSLASFLKLSYTYWLYTKDQSIFTVKWLAAVERIIQVLEEQSSPSFDEKTGLPKDPVYTFLRNTDSGTETLGLAGRGFPLNANASLIRSAFRPSDDACVLQYFIPANAMMVVELSHLNQMLQASGHADIARTALVWANKIQKGIDQHGIVDHPKFGKVYAYEVDGYGSILFMDDANVPSLLSLPYLGFVERDDPVYVNTRKMILSSEGNPYYLKGKVISGIGGPHIGLRNVWPMSLIVQALTSDDDDEIMSLLDVLKHSTAGLGLMHESVDVSSFKSFTRPWFSWANSLFAELILDLLERKPHLLKKNAS
Protein: Ras-related protein RABG3f (AtRABG3f) (Ras-related protein Rab71) (AtRab71) (Ras-related protein Rab7B) (AtRab7B) (Q9LS94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for trafficking from prevacuolar compartments to vacuoles. Involved in the trafficking of newly synthesized protein to vacuoles. Essential for plant growth. Participates in the recruitment of the core retromer components to the endosomal membrane by interacting with VPS35A.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:23362252, ECO:0000269|PubMed:24824487}; Lipid-anchor {ECO:0000305}. Vacuole membrane {ECO:0000269|PubMed:24824487, ECO:0000269|PubMed:29463724}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Prevacuolar compartment membrane {ECO:0000269|PubMed:24824487}; Lipid-anchor {ECO:0000305}. Note=Partial co-localization with VPS3 at cytoplasmic punctate structures, and with VPS39 at subdomains of the vacuolar membrane. Co-localizes with VPS18. {ECO:0000269|PubMed:29463724}.
Interaction partners:
- Vacuolar fusion protein MON1 homolog
- Vacuolar fusion protein CCZ1 homolog A
- Vacuolar protein-sorting-associated protein 33 homolog
- Vacuolar sorting protein 18
- Protein VACUOLELESS1
- Vesicle transport v-SNARE 12
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Guanosine nucleotide diphosphate dissociation inhibitor 1
Sequence:
MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASPSDPENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCASKGNIPYFETSAKVGTNVEEAFQCIAKDALKSGEEEELYLPDTIDVGTSNQQRSTGCEC
Protein: HTH-type transcriptional activator RhaR (L-rhamnose operon transcriptional activator RhaR) (P09378)
Organism: Escherichia coli (strain K12)
Function: Activates expression of the rhaSR operon in response to L-rhamnose.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01533}.
Interaction partners:
- L-Rhamnulokinase
- L-rhamnose-proton symporter
- L-rhamnose isomerase
- Melibiose operon regulatory protein
- RNA polymerase sigma factor RpoD
- HTH-type transcriptional activator RhaS
- HTH-type transcriptional regulator ChbR
- Uncharacterized HTH-type transcriptional regulator YidL
- Uncharacterized HTH-type transcriptional regulator YdiP
- Multiple antibiotic resistance protein MarA
Sequence:
MAHQLKLLKDDFFASDQQAVAVADRYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIYCPERLKLNLDWQGAIPGFNASAGQPHWRLGSMGMAQARQVIGQLEHESSQHVPFANEMAELLFGQLVMLLNRHRYTSDSLPPTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWRHLNSQKD
Protein: Cytokinin dehydrogenase 4 (EC 1.5.99.12) (Cytokinin oxidase 4) (OsCKX4) (Q5JLP4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group.
Subcellular location: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- Malate synthase
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Cytochrome c oxidase subunit 3
Sequence:
MRGAMKPSIVHCLKLLMLLALGGVTMHVPDEDDVVASLGALRLDGHFSFDDAHAAARDFGNRCSLLPAAVLHPGSVSDVAATVRRVFQLGRSSPLTVAARGHGHSLLGQSQAAGGIVVKMESLAAAAARAVRVHGGASPHVDAPGGELWINVLHETLKHGLAPRSWTDYLHLTVGGTLSNAGVSGQAFRHGPQVSNVNQLEIVTGRGEVVTCSHEVNSDLFYAALGGLGQFGIITRARIALEPAPKMVRWIRVLYSDFETFTEDQEKLIASEKTFDYIEGFVIINRTGILNNWRTSFKPQDPVQASQFQSDGRVLYCLELTMNFNHDEADIMEQEVGALLSRLRYISSTLFYTDVTYLEFLDRVHTSELKLRAQGLWEVPHPWLNLLIPRSTVHKFAKEVFGKILKDSNNGPILLYPVNRTKWDNRTSVVIPDEEIFYLVGFLSSAPSSSGHGSVEHAMNLNNKIVDFCEKNGVGMKQYLAPYTTQKQWKAHFGARWETFERRKHTYDPLAILAPGQRIFPKASLPMSL
Protein: A-type voltage-gated potassium channel KCND3 (Potassium voltage-gated channel subfamily D member 3) (Voltage-gated potassium channel subunit Kv4.3) (Q9Z0V1)
Organism: Mus musculus (Mouse)
Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62897}. Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. {ECO:0000250|UniProtKB:Q62897}.
Interaction partners:
- A-type potassium channel modulatory protein KCNIP2
- A-type potassium channel modulatory protein KCNIP1
- A-type potassium channel modulatory protein DPP6
- Inactive dipeptidyl peptidase 10
- Calsenilin
- Kv channel-interacting protein 4
- A-type voltage-gated potassium channel KCND2
- Ubiquitin-like protein FUBI
- Voltage-gated potassium channel subunit beta-1
- Sodium channel regulatory subunit beta-1
Sequence:
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEQMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTLHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSAL
Protein: adenosine deaminase (EC 3.5.4.4) (F6NKG5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Adenosine deaminase
- Adenosine kinase
- Adenosine kinase b.
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Adenosine deaminase 2-A
- Deoxycytidine kinase.
Sequence:
MSSISLKDVSAAVMVVLLVCVSECKSMPDPRQREQMLQQELLQQIGGNMELNEAEKRMDSLLYMLKMKEITLSPFPPANHFFKVRHIIQQSPIFKLLQKMPKGAALHIHNSAMVSVDWLLNATYRPNCYICFTWDGSVRFMFSTSTPFPRWGCSFWKRLDILRASLGDVTSFDNSLMRNLTLFTEDPETSYPTQDYIWKRFEKIFIALSGLITYAPVLKDHIYQGLKELYEDNIMYVELRIGQAKAYELDGTTHDRAWTIEVYRNITEQFRANHPDFIGTRVILSAHRSSSVSRVKQAVQEAIEMQRKYPEIVAGFDLVGREDTGGSIWYFRDALSLPSESQLPYFFHAGETDLDGTDVDRNVLDALLFNTSRIGHGFAIVHHPVAKQLSRSRRVAVELCPISNQVLKLVSDLRNHPAAVLMSDGHPMVVSSDDPSLFGTTGLSYDFYEVFVGIGGLSANLGTLKELAINSIRYSSLSAQLQDKAMTVWQEKWNTFIAENS
Protein: UPF0658 Golgi apparatus membrane protein C1952.10c (Q9UUJ8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKKFLSFKPAEDFLRSLKKSSQWFLLIIIVEVTITLSFEGYVFHHFRLITVEKIDVFINAMVPSTFALFCMACPYLLYTAVDALLNKDVIQMSALLIFHVSLFCLSVVQYFQIFSKDPRAIFLSALYLIDPIRLVTSFNYHERIVVNSHMLLFYLKPFVIALPVLIGVTCILLSFLVYKMNKAFGWIMYQQHGPDLRMRRRYLVYKIFMSLIKSDYYFCLTATVQYAIFFSTISRVGLALTILVFPCTIATLMTCRYAVYRENRALLGIVQFMFMCGLAYFIYNCARLYLGVDYGDIAVANICMLVFSIVTIIYLFTTIVVGFYCISNFGYGLREYLRYIHQKQKVNAAPAVPKVRMPLDD
Protein: Matrix metallopeptidase 15 (D3ZCG5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Metalloproteinase inhibitor 2
- Proheparin-binding EGF-like growth factor
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 3
Sequence:
MGSDRSALGRPGCAGSCLSSRASLLLLLLVLLDCLGGGTASEDAEVYAAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPDQFGVRVKANLRRRRRRYTLTGKTWSNYHLTFSIQNYTEKLGWYNSMEAVRRAFQVWEQVTPLVFQEVPYDDIRLRRRAEADIMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGISLFLVAVHELGHALGLEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDGKPQPTRPLPTVRPRRPGRPDHQPPRPPQPPHPGGKPERPPKPGPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQPLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPNSPKGAFLSNDAAYTYFYKGTKYWKFNNERLRMEPGHPKSILRDFMGCQEHVEPRSRWPDVARPPFNPNGGAEPETEDDSKEEDVGDKDEGSRVVVQMEEVVRTVNVVMVLVPLLLLLCILGLAFALVQMQRKGAPRMLLYCKRSLQEWV
Protein: RNA-binding protein, putative (Q381Q0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cleavage stimulation factor 50 kDa subunit
- C3H1-type domain-containing protein
- Cleavage and polyadenylation specificity factor subunit, putative
- Cleavage and polyadenylation specificity factor 30 kDa subunit
- Cleavage and polyadenylation specificity factor-like protein, putative
- Cleavage and polyadenylation specificity factor subunit 2
- Suppressor of forked domain-containing protein
- Uncharacterized protein
- Cleavage and polyadenylation specificity factor subunit 5
- RNA-binding protein RBP14, putative
Sequence:
MSSTQTTSVFFTDVPLFVEERSLRKHFESVGHITDFRLLGPPVGKDFRYGFAEYLDSTSAEEAIARLNGTSFGGRPMKVMSAAATRGRKRQRQQNASHQQQPAPRGGMTFPRGYTDPVLGRDDTSIFECLQGMQQSDAYEAVEQLRVLVLERKNEARKLLENNPALRLAVVMILQHAGRLPFGPLPPEAIQHGGIRVDAPVPAAPAEGEGEKVEPPREQNDEIIEILSKLSEEEVERIVSMTDEDLNRIPDVSQRQQIGVLRERLLELAADLE
Protein: Cyclin-dependent kinase 5 activator (F1M491)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}.
Interaction partners:
- Cyclin-dependent kinase 5
Sequence:
MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDAPDGGGAAKPLAVPVPTVPASAATCEPPSGGSAAAPPPGSGGGKPPPPPPPAPQAAPPAPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASTGGPPSGSASTTSSSTARDSCAAGAKHWTMNLDR
Protein: RanBP2-type domain-containing protein (Q57UY6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQRCVHILSRHYLAHHLGSRASVALLCSRAYFVTTPCLFARRIKGRRTRHREPAEGDWLCQCGEPNYKSKRECYKCGAPAPPLPPGVRRPSLPGEDPHDWACPCGQMNFRGSVVCHKCQQPKPTPPPLPGKEVTLWTCPKCKGVNRNVRKFCFKCSSPSPLLTFKPAV
Protein: Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) (O55096)
Organism: Rattus norvegicus (Rat)
Function: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (By similarity). Also cleaves Arg-Arg-beta-naphthylamide.
Subcellular location: Cytoplasm.
Interaction partners:
- Kelch-like ECH-associated protein 1
- Partner and localizer of BRCA2
Sequence:
MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSKAAQQHPEEVRSLWQTCGELMFSLEPRLRHLGLGKEGVTTYFSGDCAMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKYHYEVRLASVLNTEPALDSELTSKLKSYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQMLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAMVNKDMSAKFERLVASAEQLLKELPWPPAFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATKREKLTFMEEEDKDLYIRWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLNPQVLQIFGFEGTDAEDVIYVNWLNMVRAGLLALEFYTPETANWRQAHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVHLDRSKIRSVGKPALERFLRRLQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSEVQLVEYEASAAGLIRSFCERFPEDGPELEEVLTQLATADAQFWRDQVQEAPSGQA
Protein: Sodium-dependent nutrient amino acid transporter 1 (Q29GB8)
Organism: Drosophila pseudoobscura pseudoobscura (Fruit fly)
Function: Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MELKGVHQQNGTSNGTGAAGTEGESPPPAPAPATAEAAASLETTTEKVDAEQQKTERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFATICIITYYSSLLALTLFYLFVSFQSVLPWSYCWEEWMNCVDSRPQEDTDALLLSSSNVTNVTALTDTVKLQSSSELYFLNVVIKEKMDISDGIGDPDWKLTLALFVSWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFILLVRAVTLEGARDGIIFFLEPQWGELLNPTVWKNAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTILCDQFKSWKYWKVALATSICGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWIYGMQNFCDDVEFMCNRRVSLYWRVCWSFFTPVMMIVIFIYSMVTIEPITYSEQFFPEAGNVAGWLLFGIGAAQFPLWWMWYISHHREGSLGQSFVASLRPSDKWGPANPETKRQWVIFKNEKAAQRATKKQSSKMGAFWQKLGHFCGSNT
Protein: Transmembrane proteins 14C (Q381S7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MANVIASGTLAVLLPLGGYMGYSKKNSVASLAAGVSAGLISAVSLIYLLSDSNHKVANRVEACMSFLLSAVMAFRYLKSRKPTPLYVSLLTGICFLFGFAPYSF
Protein: NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase) (Q9V3T9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for synthesis of steroid hormones, for olfactory sensory behavior and completion of the second larval molt (a steroid mediated developmental transition) and pupariation.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P48360}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Glutamate synthase
- Adrenodoxin-like protein 2, mitochondrial
- Adrenodoxin-like protein 1, mitochondrial
- FI21247p1
- Electron transfer flavoprotein subunit beta
- GH14121p
- LYR motif-containing protein 4 homolog
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MGINCLNIFRRGLHTSSARLQVIQSTTPTKRICIVGAGPAGFYAAQLILKQLDNCVVDVVEKLPVPFGLVRFGVAPDHPEVKNVINTFTKTAEHPRLRYFGNISLGTDVSLRELRDRYHAVLLTYGADQDRQLELENEQLDNVISARKFVAWYNGLPGAENLAPDLSGRDVTIVGQGNVAVDVARMLLSPLDALKTTDTTEYALEALSCSQVERVHLVGRRGPLQAAFTIKELREMLKLPNVDTRWRTEDFSGIDMQLDKLQRPRKRLTELMLKSLKEQGRISGSKQFLPIFLRAPKAIAPGEMEFSVTELQQEAAVPTSSTERLPSHLILRSIGYKSSCVDTGINFDTRRGRVHNINGRILKDDATGEVDPGLYVAGWLGTGPTGVIVTTMNGAFAVAKTICDDINTNALDTSSVKPGYDADGKRVVTWDGWQRINDFESAAGKAKGKPREKIVSIEEMLRVAGV
Protein: Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) (Q03169)
Organism: Homo sapiens (Human)
Function: May play a role as a mediator of inflammation and angiogenesis.
Interaction partners:
- Exocyst complex component 4
- Exocyst complex component 2
- Exocyst complex component 8
- Exocyst complex component 7
- Exocyst complex component 1
- Exocyst complex component 5
- Exocyst complex component 1-like
- Exocyst complex component 6
- Exocyst complex component 6B
Sequence:
MSEASSEDLVPPLEAGAAPYREEEEAAKKKKEKKKKSKGLANVFCVFTKGKKKKGQPSSAEPEDAAGSRQGLDGPPPTVEELKAALERGQLEAARPLLALERELAAAAAAGGVSEEELVRRQSKVEALYELLRDQVLGVLRRPLEAPPERLRQALAVVAEQEREDRQAAAAGPGTSGLAATRPRRWLQLWRRGVAEAAEERMGQRPAAGAEVPESVFLHLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVAQFELCERDTYMLLLWVQNLYPNDIINSPKLVGELQGMGLGSLLPPRQIRLLEATFLSSEAANVRELMDRALELEARRWAEDVPPQRLDGHCHSELAIDIIQITSQAQAKAESITLDLGSQIKRVLLVELPAFLRSYQRAFNEFLERGKQLTNYRANVIANINNCLSFRMSMEQNWQVPQDTLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHTRWAAPVETLENIIATVDTRLPEFSELQGCFREELMEALHLHLVKEYIIQLSKGRLVLKTAEQQQQLAGYILANADTIQHFCTQHGSPATWLQPALPTLAEIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSNSEVKRIRSILDVSMGAQEPSRPLFSLIKVG
Protein: Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (P9WQD1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. M.tuberculosis may use AcsA for both acetate and propionate assimilation.
Interaction partners:
- Malate synthase G
- Citrate synthase 1
- 2-methylcitrate synthase
- Putative citrate synthase 2
- Acetate kinase
- Phosphate acetyltransferase
- 2-oxoglutarate oxidoreductase subunit KorA
- Probable fatty oxidation protein FadB
- Putative acyltransferase Rv0859
- Aldehyde dehydrogenase
Sequence:
MSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWAKQANRLSWTTPFTEVLDWSGAPFAKWFVGGELNVAYNCVDRHVEAGHGDRVAIHWEGEPVGDRRTLTYSDLLAEVSKAANALTDLGLVAGDRVAIYLPLIPEAVIAMLACARLGIMHSVVFGGFTAAALQARIVDAQAKLLITADGQFRRGKPSPLKAAADEALAAIPDCSVEHVLVVRRTGIEMAWSEGRDLWWHHVVGSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHTSGGYLTQCCYTMRTIFDVKPDSDVFWCTADIGWVTGHTYGVYGPLCNGVTEVLYEGTPDTPDRHRHFQIIEKYGVTIYYTAPTLIRMFMKWGREIPDSHDLSSLRLLGSVGEPINPEAWRWYRDVIGGGRTPLVDTWWQTETGSAMISPLPGIAAAKPGSAMTPLPGISAKIVDDHGDPLPPHTEGAQHVTGYLVLDQPWPSMLRGIWGDPARYWHSYWSKFSDKGYYFAGDGARIDPDGAIWVLGRIDDVMNVSGHRISTAEVESALVAHSGVAEAAVVGVTDETTTQAICAFVVLRANYAPHDRTAEELRTEVARVISPIARPRDVHVVPELPKTRSGKIMRRLLRDVAENRELGDTSTLLDPTVFDAIRAAK
Protein: Meiotic expression up-regulated protein 26 (O14220)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable endonuclease C19F8.04c
- Uncharacterized protein C23H3.15c
- Probable acetyl-coenzyme A synthetase
- Secretory component protein psh3
- Succinate--CoA ligase subunit alpha, mitochondrial
Sequence:
MNSNEIENFIYLNNTLLSEVPEPNSVFYTPKCFSNSKLPHQSDLEEPSSACSLSKNTIIDGGADEPYDSSDSCATFEFADFFKDNLDDFALDGPIININHVNQTSPYTHHNAEPLHDLQTFSSNLNHSNNRRQTICNFNMANDASKENETPYMVLNNKFNPVLTTEYTQQHLVQCKMVLENHITSRFPHFYTKLPDVSLVPNNMPHYPDEVTAKSAPKDDFYVPRFTRGHGISKLGLCPICSHQGEFIWLRTKTSAYWYHMNFVHGIHSKGRPYQPPIEFRTVRLRKTRNAIGVPNKKYMIEGKCHQCNKWIRCQGRKDVSVKIPEIFWWRHAHRCHIITTDLR
Protein: KilA-N DNA-binding domain-containing protein (Q9A350)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
Sequence:
MTNLIDPIHAPAPPAVFEVRRQWVVLDADLARLFQVETRSLNQQVQRNARKFEGFAFRLSDEERANLTSQNVISSDGHGGRRHLPFAFTEHGVVMAATVVKSEQAITATRFIISVFVEARRKAPDGSNLPGLMDARRLPSLEAQTRLTLSGKLNDALGRVLDAIADPVAQTTVRDEARVLAAEGLASLKEHLRTAGVQNEKTLAEVRKLLAEAEAVEAETALRVTETQHRQLALLAKQLRLVLVAQQALDRGGVEDLLAVLKDLERS
Protein: C-type lectin domain family 2 member G (DDV10) (Osteoclast inhibitory lectin-related protein 1) (Ocil-related protein 1) (Q9D676)
Organism: Mus musculus (Mouse)
Function: Inhibits osteoclast formation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Killer cell lectin-like receptor subfamily B member 1
Sequence:
MNITRASLPMLNTTCSCRREKWNFLGRYEGTFDYWIGLHRASSKHPWMWTDNTEYNNMFVYHMNAQCLKKPEEGESSPGTGGVHSYKILQRNSLRAISPESSAKLYCCCGVIMVLTVAVVALSVALPATKTEQILINKTYAACPKNWIGVGNKCFYFSEYTSNWTFAQTFCMAQEAQLARFDNEKELNFLMRYKANFDSWIGLHRESSEHPWKWTDNTEYNNMIPIQGVETCAYLSGNGISSSRHYIPRIWICSKLNNYSLHCPTPVPV
Protein: N(6)-L-threonylcarbamoyladenine synthase (EC 2.3.1.234) (G3V445)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVIAYSEHRYRIFGETIDIA
Protein: Snl1p (Q59NB3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Heat shock protein homolog SSE1
- Hsp70 nucleotide exchange factor FES1
- Nucleotide exchange factor SIL1
- Heat shock protein HSP70
- Endoplasmic reticulum chaperone BIP
Sequence:
MEKVTEHLNEFKSKIPNSVEELQDYLDYLKEKIPTSYDDFKPQIEYVKSIKGEDVVNDFKNLKVSPITVSLTLVAFTTLYLFGKLIGGGRAEETPKKKPRKKLTKAQKANRQIQEILDYVESTYVPEIDKFIETYKELSSEDVEYKFNYFEEMLLKELMKLDAIDVTSNEILRDNRRKVIKFIQDHQKRLDKFKKEIST