wanglab/gogpt-training-data huggingface dataset:
Protein: FACT complex subunit SSRP1 (DNA unwinding factor 87 kDa subunit) (DUF87) (Facilitates chromatin transcription complex subunit ssrp1) (Structure-specific recognition protein 1) (Q9W602)
Organism: Xenopus laevis (African clawed frog)
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q05344}. Chromosome {ECO:0000250|UniProtKB:Q05344}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q05344}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. {ECO:0000250|UniProtKB:Q05344}.
Interaction partners:
Sequence:
MADTLEFNDIYQEVKGSMNDGRLRLSRAGLMYKNNKTGKVENISAADIAEVVWRRVALGHGIKLLTNGGHVYKYDGFRETEYDKLFDYFKSHFSVELVEKDLCVKGWNWGSVRFGGQLLSFDIGDQPAFELPLSNVSQCTTGKNEVTLEFHQNDDSEVSLMEIRFYVPPTQDDGGDSVEAFAQNVLSKADVIQATGDAVCIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDMTLTLNMSEEEVERRFEGKLKKSMSGCLYEMVSRVMKALVNRKITVPGNFLGHSGSQCITCSYKASSGLLYPLERGFIYVHKPPVHIRFDEITCVNFARGTTTTRSFDFEIETKQGSQYTFSSIEREEYGKLFDFVNAKKLSIKNRGLKEGMKPAYDDYADSDEDQHDAYLERMKEEGKIRENADSDESGDETDESFNPGEEEEEVAEEFDSNPSASSSSADSDDDTDKKKDAKRAKIVKQKKPRKKPEAKKTKDPGAPKRPMSAYMLWLNASREKIKSENPGISITDLSKKAGEIWKNMSRDKKEEWDRRAEEAKRDYEKAMKEYNTSAPTEASKKEKKTKGEKKKAETSEKKKQKPSSPARAAPKLNSESFKSKEFVSSDDSSSDDSAQKKDSEEIASTPASSAESGSD
Protein: Uncharacterized protein C1685.04 (O74324)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MKQEYIPLDEFPNKSNEGMLNDEGTSSSGLSTRTRSLELFDNMEESGSFPKVERKIQSLLDELAEVLFQSKQPNDLTRIRKAIAEQLQLWCQACQENADLYRSQQRKLKSRWDSQTDILSQIESTKASLAEVHKAEEISNLKTSITHLDEEIQILQEKLAIVTNQRNTLVKRLQTYDNLEKKKALSMEDRLLTLQEQYDAHANVSSLEKRMEVLKKREDLLRLMVGQALPGMQFFQRLIHQIQAVETKLISILGPTSLSEAALPPLTDVQRTSVLSLLTSTLHSLESARQIADSNTWKPIIVCLELEIVYFENMLTAITSTPVSS
Protein: Uncharacterized protein (Q383J5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNPPTTQANGDRPQRQFSGANRQPATLSHEKSHHTPMRRLIMTNHNRHAEQKGQRQGNEAAQSDGELLGRAKTHSSFAELRRSLVDASAVAEFIQKNYTGRLRDPKQLNNFFQALSNRPETIFTELCGLYKKEVCLMLERMLEVYSTATSTSAVPISPAAHEFIIRCEQNGVRRMTWADELTQTNGTQKVEKGEEGEEGVDAKASASASGPVPVLLFSPRELIKKVANVEPRGRLERMIEMSTTTADLESCARKLQTVATPAQEGKKNLEYAAVCRLLSKLASKTRRTCEAIIRTATEAGKLPVDDLSALDQVIGTLLAVTQRSFSERPPVVQQHPIAKLSNLVKWCNTHNLLQYNADKYSALVEALEKQSSLELHAQAAQLETVLLLKGLQPGDDAAATETLQKLWNESLGRYEPCSADVLSSIAVVCRADGISDTLRTQVAQRLVLTQQCVQRERKSNETILPRRALSFVLVEQSKEKRDAVKRMLAKEENKKRGRD
Protein: UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) (Q6P5E4)
Organism: Mus musculus (Mouse)
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9NYU2, ECO:0000255|PROSITE-ProRule:PRU10138}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Selenoprotein F
- Calnexin
- UDP-glucose:glycoprotein glucosyltransferase 1
- Endoplasmin
- Protein OS-9
- Protein disulfide-isomerase A4
- Calreticulin
- Neutral alpha-glucosidase AB
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Hypoxia up-regulated protein 1
Sequence:
MCSRGDANTADAAAARRVTGLRYNMRLLIALALPCLFSLAEANSKAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEATQNIGSSDHHDTDHSYYDAVLEAAFRFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKSFLSVHGKQTCDLDTLESLLLTAADRPKPLLFKGDHRYPSSNPESPVVILYSEIGHEEFSNIHHQLISKSNEGKINYVFRHYISNPSKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNATVIGESDPIDEVQGFLFGKLRELYPALEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAASGALSLVVMKDISQNFPTKARAITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDIFSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNIQPSETDYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIIDPVHETTAELISIAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDGYHAFQTLTQIYNKVRTGETVKVEHVVSVLEKKYPYVEVNSILGIDSAYDQNRKEARGYYEQTGVGPLPVVLFNGMPFEKEQLDPDELETITMHKILETTTFFQRAVYLGELSHDQDVVEYIMNQPNVVPRINSRILTAKREYLDLTASNNFYVDDFARFSALDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINNPSQEISDSSTPIFRAIWAALQTQASSSAKNFITKMAKEETAEALAAGVDIAEFSVGGMDVSLFKEVFESSRMDFILSHALYCRDVLKLKKGQRVVISNGRIIGPLEDNELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGEARIEYQFFEDKHSAIKLKPKEGETYYDVVAVVDPVTREAQRLAPLLLVLTQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADSSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSIVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTIVDTIVMANLGYFQLKANPGAWILRLRKGRSDDIYRIYSHDGTDSPPDANDVVVILNNFKSKIIKVKVQKKADMANEDLLSDGTNENESGFWDSFKWGFSGQKAEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQTLFQEEKELGTLHTEETQEGSQKHEEL
Protein: GPI transamidase component PIG-S-like protein (Q8W4D7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- GPI transamidase component family protein / Gaa1-like family protein
- GPI transamidase subunit PIG-U
- GPI transamidase subunit PIG-U
- Peptidase C13 family
- GPI transamidase component Gpi16 subunit family protein
- GPI inositol-deacylase
- Uncharacterized protein
- GPI ethanolamine phosphate transferase 3
- At1g16040
- Mannosyltransferase APTG1
Sequence:
MEEISDRLNPGITPEFDPKTMRSTKPGLKRLFITSSVLFSFLLGVPFLWKSVEIYRSPLPFHDIDSLSDQLESTPLRFPCNFHAVFVGFRSTDPDNLRSQIQDGINQLTHQSSQCGSCDFSLSVTVQNREDQCSDTLAHSSTTCSYRCGVIKRNGFSVGLDDTVDESLNDVFSGCSENSGKMYSVVVVNKENANGGDEVKAVVGKRRHAWIVGNGLEERYGDIVARVSEIFVQVFMNGGREEDSIQGEFMPVGSDGKIVLSFSLLNSNPRDWVYDWDFQRIDEALLAPVTKALAPIANITVESQVLYHTPKSSFSSWDKKLQSYIFRTSDLPFFVNSNEWHLDTSAGASGRSKILQFVVYIPSGKECPLLLQLPNVEISKTNGFISPMWGGVIVWNPGNCDKDSESPSRNTISLQDLEQIVEIFLGQFRQLFGFKSEAKYTTGLGTYKILTSERGFTEWELDVLSRKHTCFNLHSCSTTLGSLSRLVRSLPRMIIKDEIGEQVKYSLKAAKLAQSNASLGGYSSSASSSREARSLAENAFFHPSIMSVSYFSYEHCFAVYSPFFLPVVGHVVLAAVREWKRYKQEKAKYLTWLTRKKTT
Protein: Hap43p (A0A1D8PF19)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Hap5p
- Transcriptional activator HAP2
- Hap3p
- Suppressor of ferric uptake 1
- Hap31p
- Transcriptional regulatory protein SEF1
- Mlc2p
- Siderophore transporter
- Fth1p
- Fre9p
Sequence:
MPAKGPNIIPKQAPSPIAIAGSPPSSSASTPRSAASPPVSVNTKYSPNTNSNTIMPRQVMSIQTSKEWVLPPRPKPGRKPSVDTPASKRKAQNRAAQRAFRERRATRVQELEQKLMEVEKERDIKEMALVNTINKLKVENQFLVKNLEQLKGEMNQMKQSFSRSQQQLISKSSPAASTASAQQIKPTFSFASNSAPSSHPSPSHHNSISPTGSSYSVQQISPAPSTDSPPNSYNLSNDSYRQFHSTLTPISNNNTPDKPLSAADVANFDCGVCPKEECLCESVGLKEPTKDKTENAKKKLQDQVNSFKPMPAVSLSRKRKIKSTDEEQEIDFTKQFSVKAKPMPDLKKLKKTTFSQPQTETASTFNEDSPVDNCGFCSDDTPCVCREAAKEAAKLNEYLNNPHQSSIMEEEISEEAKTLPPLQTNNPNHNFSKSALPVMHPGPTVEIREFTNINAVPNVLPASKNENEKEESTKDTSSDGGCTGNPGTCRQCQMDPMSTLFCTTVASRSTKSDSVSSTRQSISRTNSKTSISIDSLNNPQSPIPPPLLANNKTGGSNAPTPTPAPSTPSHSSSVSSNSGIFIPCADAYKTLSRHKKFNSVDFTTLVGKLTTRGMQVEVQSVANVLRELDRRAYN
Protein: Restin homolog (Cytoplasmic linker protein 190) (Microtubule-binding protein 190) (d-CLIP-190) (Q9VJE5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization.
Subcellular location: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9472041}. Golgi apparatus {ECO:0000269|PubMed:11076973}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:32066907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32066907}. Note=Microtubule-associated (PubMed:9472041). Lva-CLIP-190 complexes are found at the Golgi (PubMed:11076973). In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) (PubMed:32066907). {ECO:0000269|PubMed:11076973, ECO:0000269|PubMed:32066907, ECO:0000269|PubMed:9472041}.
Interaction partners:
- Eb1, isoform F
- CLIP-associating protein
- Serine/threonine-protein kinase mTor
- Protein lava lamp
- Dynactin subunit 1
- Dynactin subunit 1
- Dynactin subunit 2
- FI16628p1
- MIP05284p
- GH14206p
Sequence:
MSDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETLPMDFTKPHAFDALTKRKPAPRLFCDICDEFDQHDTEDCPIQGSEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFGHDTSECADDETY
Protein: CBY1-interacting BAR domain-containing protein 2 (Protein FAM92B) (Q6ZTR7)
Organism: Homo sapiens (Human)
Function: May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q3V2J0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3V2J0}. Note=Extensive colocalization with CBY1 at mother centrioles. {ECO:0000250|UniProtKB:Q3V2J0}.
Interaction partners:
Sequence:
MNIVFSRDSQVRVMENTVANTEKYFGQFCSLLAAYTRKTARLRDKADQLVKQLIDFANSENPELRATMRGFAEDLAKVQDYRQAQVERLETKVVNPLKLYGAQIKQTRAEIKKFKHVQNHEIKQLEKLEKLRQKSPSDQQMIGQAETRVQRAAVDSSRTTLQLEETVDGFQRQKLKDLQKFFCDFVTIEMVFHAKAVEVYSSAFQTLEKYDLERDLLDFRAKMQGVYGHYDTRLLANTSPPPSVLQSLASQGTLQVQLSRANEDPEHPHANHGRFSLCEWVVKGQPAHCVCGQGGHLMLPGHSL
Protein: T. brucei spp.-specific protein (Q580M4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPAEGPNPREVTSDASVSQEEENLGTDQGGSAKQEREVMTPNNDIHYTSVGVLARGVADPSYSHVVSSDVSYKSSTALSYPEESLSPSCASFSEAVDDSPTDAEHQMGASPCNSIIGSIDMAAAINVLRSRLGTTHKKVMSVGSPLYRRDGKGGCSCKSPRASSPGSMTSRTFKASITHNQKASAASSIADNGSPSAMASQTRRPLKGCEPRSPSRREVVMIREDSNVRFGVDNERECHGDDVNEDVPRLVLTRESLESMCGKSNIRVSSPLPPIDVSEHGSPRKCIMIRSTASPTNEKVHTPVSKVPPFKGSWASSPKASMEKKGPNTSVLLPTQAAPISIPCVGTGLGNCQLRGNGLWGNDTNAVLLGERTTNVGTFASSPLPRALPEPRKAVPSLTKDRNGNASL
Protein: Pleiotrophin-B (PTN-B) (Pleiotrophic factor-beta-2) (PTF-beta-2) (X-PTF-beta2) (P48533)
Organism: Xenopus laevis (African clawed frog)
Function: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity). Has antibacterial activity against both Gram-positive and Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P21246}.
Interaction partners:
Sequence:
MHHQHGLFMLALLAFLLVMTVLGTDTGKKDKQEKKVKKSDCGDWQWSVCVPTSGDCGLGTREGTRSGKECKQTIKTQKCKIPCNWKKQFGAECKYQFQEWGDCDPETGLKTRNGNLKRALHNAECQKTVTLSKPCGKVTKPKLQESKKKKKEGKNKEKLLD
Protein: Oxysterol-binding protein 1 (Q3B7Z2)
Organism: Mus musculus (Mouse)
Function: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P22059}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P22059}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P22059}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22059}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P22059}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22059}. Note=Predominantly cytosolic. {ECO:0000250|UniProtKB:P22059}.
Interaction partners:
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B
- Phosphatidylinositol-3-phosphatase SAC1
- Pleckstrin-2
- Pleckstrin
- ADP-ribosylation factor 1
- Golgi resident protein GCP60
- Membrane-associated phosphatidylinositol transfer protein 1
Sequence:
MAATELRGVVGPGPAAIAAPGGGGAGPPAVGGGGGRGDAGPGPGVAAATAATAGGPGPGAGGVAAGGPGSAPPAAGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDDSGDEESVSQTDKTELQSTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANPPGSAGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDVSLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSICEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQAASGENGGDARQRGHEAEDSRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAAKATEDGTPHDPYKALWFERKKDPVTRELTHIYSGEYWECKEKQDWGSCPDIF
Protein: Pre-mRNA-splicing factor U5-Cwc21 (Q38FI2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Essential protein involved in pre-mRNA cis- and trans-splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19429779}. Nucleus {ECO:0000269|PubMed:19429779}. Note=Found predominantly in the nucleus.
Interaction partners:
- Pre-mRNA-processing factor 19
- Cell division control protein, putative
- PRP8 protein homologue
- G10 protein
- U5 small nuclear ribonucleoprotein component, putative
- Pre-mRNA splicing factor, putative
- MI domain-containing protein
- Uncharacterized protein
- Sm protein F
- Uncharacterized protein
Sequence:
MLTTAKANPLEALRSAKENKELSGQLEHHRSLRAIKLKVLLYREEREAAGVPPDVISRECATLHGSLLRNYMEEAQEARRLGAAELAQKTAERFASAFQVRPGSLGDAFDRRHREVERQAAEGARKEAIERRIVERVKRIKGE
Protein: Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) (Q06124)
Organism: Homo sapiens (Human)
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26742426}. Nucleus {ECO:0000269|PubMed:26742426}.
Interaction partners:
- Epidermal growth factor receptor
- Tyrosine-protein phosphatase non-receptor type substrate 1
- Insulin receptor substrate 1
- GRB2-associated-binding protein 1
- Platelet-derived growth factor receptor beta
- Fibroblast growth factor receptor substrate 2
- GRB2-associated-binding protein 2
- Son of sevenless homolog 1
- Platelet endothelial cell adhesion molecule
- Growth factor receptor-bound protein 2
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Protein: LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (P63006)
Organism: Mus musculus (Mouse)
Function: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:8793615}.
Interaction partners:
- LIM domain-binding protein 1
- Paired box protein Pax-2
- Scaffold protein ILK
- Cyclin-K
- Paired box protein Pax-8
- Eomesodermin homolog
- Homeobox protein SIX2
Sequence:
MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLDHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW
Protein: Protection of telomeres protein 1 (A0A590UJF7)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTANQHSDVICQSEPDDSFPSSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKGRKVAVHFVKNNGILPLSNECLLLIEALGIVPLQYVFVMTFTLDDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI
Protein: Pre-mRNA-splicing factor cwf23 (Complexed with cdc5 protein 23) (Q9P7C6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor cdc5
- Presequence translocated-associated motor subunit pam17
- Pre-mRNA-splicing factor cwf26
- Branchpoint-bridging protein
- Pre-mRNA-splicing factor cwf28
- Pre-mRNA-splicing factor cwf24
- Pre-mRNA-splicing factor sap114
Sequence:
MASEGDSIDYYELLGINEDAQDQEIHRAWRKTSLKYHPDKNPNDPKAAEKFHMLQLAYNALIDVQLRKAYDSERFAKLARKRREEAFNFQRKSMVDDLRERERQFYDSLEKKENERDRLQEKLRALQEESANLRRQRENRLREEQEQSKRRKQETPSSKISELDRSIRIRWKRKYADQVNDAYLRSIYSSFGTLQNVVIQKDISKEKKYVYSIIVFETLSSAYSAINAEKPSKIYDVQWLKPPKSNSNTPTEKDTTVEDYEEITIMRMKQKHKQKQKENERKATSTMNA
Protein: serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) (Q5T5C7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKRKNNLHLSTQNKLEASLFSPKKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
Protein: Beta-adducin (Erythrocyte adducin subunit beta) (P35612)
Organism: Homo sapiens (Human)
Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
Subcellular location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Dematin
- Protein 4.1
- Alpha-adducin
- Ankyrin-2
- Ankyrin-1
- Ankyrin-3
- Tropomodulin-4
- Tropomodulin-1
- Tropomodulin-2
- Tropomodulin-3
Sequence:
MSEETVPEAASPPPPQGQPYFDRFSEDDPEYMRLRNRAADLRQDFNLMEQKKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVFPTSSMNVSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSSCFPVDTTGFCLHSAIYAARPDVRCIIHLHTPATAAVSAMKWGLLPVSHNALLVGDMAYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGVVALGDTVEEAFYKIFHLQAACEIQVSALSSAGGVENLILLEQEKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKTKHKSEVEIPATVTAFVFEEDGAPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADEVQRSMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLEMRNKIREQNRQDVKSAGPQSQLLASVIAEKSRSPSTESQLMSKGDEDTKDDSEETVPNPFSQLTDQELEEYKKEVERKKLELDGEKETAPEEPGSPAKSAPASPVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPETTQPEGVVVNGREEEQTAEEILSKGLSQMTTSADTDVDTSKDKTESVTSGPMSPEGSPSKSPSKKKKKFRTPSFLKKSKKKEKVES
Protein: Protein csh3 (O43125)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Actin-binding protein wsp1
- Ras guanine nucleotide exchange factor efc25
- Protein ste6
- Protein BZZ1
- Ascus wall glucan endo-1,3-beta-D-glucosidase
Sequence:
MDHKNYLNHVIRGIYNDFQFLVDEGVVERSALDWVHANIHLQDGPASPVTAPAAQPVESSVPLPLPKRKSSVEKRAGSVASAVAAMSLSQNSGEKRTPEEPRKLPGVPAPQKQSEASSVNSSTEKLPPPPSYPGPNTAHKNVERVLAMYDFPGPDAGDLGFHAGEVIIVLEHVNNDWWRGELNGKEGIFPSNYVRLLEDSAVKAQPPPPPPQQNYPPAASSSAPPMQYQQTAYPPQQAPYPPVQAYPQAPQQPIVVAQPTEHKHSSTFKKIGSGLGSAFVFGAGATAGADLVNSIF