wanglab/gogpt-training-data huggingface dataset:
Protein: Endoglucanase 25 (EC 3.2.1.4) (Cellulase homolog OR16pep) (Endo-1,4-beta glucanase 25) (Protein KORRIGAN) (Protein RADIALLY SWOLLEN 2) (Q38890)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for cellulose microfibrils formation. Involved in cell wall assembly during cell elongation and cell plate maturation in cytokinesis. Required for secondary cell wall formation in the developing xylem. May cycle through different intracellular compartments, including plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9755157}; Single-pass type II membrane protein {ECO:0000269|PubMed:9755157}. Note=Cell plate.
Interaction partners:
- Cellulose synthase A catalytic subunit 1
- Cellulose synthase A catalytic subunit 3
- Protein CELLULOSE SYNTHASE INTERACTIVE 1
- Cellulose synthase A catalytic subunit 6
- Cellulose synthase A catalytic subunit 8
- Beta-glucosidase 7
- Cellulose synthase A catalytic subunit 4
- Chitinase-like protein 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Sequence:
MYGRDPWGGPLEINTADSATDDDRSRNLNDLDRAALSRPLDETQQSWLLGPTEQKKKKYVDLGCIIVSRKIFVWTVGTLVAAALLAGFITLIVKTVPRHHPKTPPPDNYTIALHKALKFFNAQKSGKLPKHNNVSWRGNSGLQDGKGETGSFYKDLVGGYYDAGDAIKFNFPMAYAMTMLSWSVIEYSAKYEAAGELTHVKELIKWGTDYFLKTFNSTADSIDDLVSQVGSGNTDDGNTDPNDHYCWMRPEDMDYKRPVTTCNGGCSDLAAEMAAALASASIVFKDNKEYSKKLVHGAKVVYQFGRTRRGRYSAGTAESSKFYNSSMYWDEFIWGGAWMYYATGNVTYLNLITQPTMAKHAGAFWGGPYYGVFSWDNKLAGAQLLLSRLRLFLSPGYPYEEILRTFHNQTSIVMCSYLPIFNKFNRTNGGLIELNHGAPQPLQYSVNAAFLATLYSDYLDAADTPGWYCGPNFYSTSVLRDFARSQIDYILGKNPRKMSYVVGFGTKYPRHVHHRGASIPKNKVKYNCKGGWKWRDSKKPNPNTIEGAMVAGPDKRDGYRDVRMNYNYTEPTLAGNAGLVAALVALSGEEEATGKIDKNTIFSAVPPLFPTPPPPPAPWKP
Protein: Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) (P18614)
Organism: Rattus norvegicus (Rat)
Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin beta-1
- Integrin beta-3
- Integrin beta-6
- Paxillin
- Integrin beta-4
- Integrin beta
- Vasodilator-stimulated phosphoprotein
- RCG21066.
- Ig gamma-1 chain C region
- Integrin alpha-6
Sequence:
MVPRRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKARTGDVYKCPVGRERAMPCVKLDLPVNTSIPNVTEIKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIVIVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKIGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKANQMVIPHNTTFQTEPAKMNEPLASYLGYTVNSATIPGDVLYIAGQPRYNHTGQVVIYKMEDGNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWARDVAVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATMCFHVKLKSKEDSIYEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVRESECIRHSFYMLDKHDFQDSVRVTLDFNLTDPENGPVLDDALPNSVHEHIPFAKDCGNKERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLTVKNKGDSAYNTRTVVQHSPNLIFSGIEEIQKDSCESNQNITCRVGYPFLRAGETVTFKIIFQFNTSHLSENAIIHLSATSDSEEPLESLNDNEVNISIPVKYEVGLQFYSSASEHHISVAANETIPEFINSTEDIGNEINVFYTIRKRGHFPMPELQLSISFPNLTADGYPVLYPIGWSSSDNVNCRPRSLEDPFGINSGKKMTISKSEVLKRGTIQDCSSTCGVATITCSLLPSDLSQVNVSLLLWKPTFIRAHFSSLNLTLRGELKSENSSLTLSSSNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK
Protein: Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a) (Q13478)
Organism: Homo sapiens (Human)
Function: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Interleukin-37
- Interleukin-18
- Interleukin-18 receptor accessory protein
- Interleukin-1 receptor accessory protein
- Interleukin-18-binding protein
- Single Ig IL-1-related receptor
- Interleukin-33
- Interleukin-1 alpha
- Interleukin-1 beta
- Interleukin-12 receptor subunit beta-1
Sequence:
MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES
Protein: Kinesin-like protein (Q57XC6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin, putative
Sequence:
MRTNEERDDKGGFIAEPKLLAGPAQKKGAPSPAKKRATSPFKTVPNHLNPNKQHGDSMNGHNTSMENADENSAAFRSRATEIMRFRVYARVRPFIPEELADMEGQERRSVVEMTENKTVILDPKDGWAPKAQFEFDASLWSIPPEHRIVHTFNDTRHSTYATQRNVYDVIAKDLVPHVFDGFNSCVLTYGLTGSGKTYTMMGKYDPRATCGGDGEEGIIPRVSNDLFTILDKKRKEEEKPNIRFRIEVTFVEIYMERVRDLLDPALKNSKGSEKLQDARIRQDPYSGPFVEGVTKYQAENWAQCCLLLERGSTHRTTCATAVHNQSSRSHAIFQLTVIQEETIPAKDRYSRPTVRCQAGRINLVDLAGSERGGFQDYVKESAAINTSLLALRRVIDNLTERQNVLMEQAKAEVTGGYFQERTLPQVPFRDSVLTWLLSDSIGGNARTTMVATLSPLAKNYGDTLATLQWSSKARNLVTLVKVNDAQTTVTDGMTSKAGELHNAVRIQRQNMDTLLESLRSKQAIAENLEKEMGSMTRQMTSIDTETNKMIRKRQAVTVQRTLLRKVWAKQIKTLEERLQASQKRLAQKNATVANSNRQRDDALERENAVKRKLQNLKAREEELHKLVAKNDATDEAFREELASAELRYQTEMEAAGADNVVSRLTESIENRTRMERRKLDDLREKVKAAERKAISMEAKVNESKQEEWKEQVRRDGEEVVQLRSKLGELQARWDAVREENDSLKAMVKRK
Protein: Bruchpilot, isoform J (A0A0B4K7K9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Rab3 interacting molecule, isoform F
- Liprin-alpha, isoform E
- Fife, isoform D
- Glutamate receptor IIC
- Glutamate receptor IIA
- Synaptotagmin 1
- Protein elav
- Synapsin
- Vesicular glutamate transporter, isoform A
- Microtubule-associated protein futsch
Sequence:
MSRDDYNPVTSSGVRSPGRVRRLQELPTVDRSPSRDYGAPRGSPLAMGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAHAMDYPRTRYQSLDRGGLVDPHDREFIPIREPRDRSRDRSLERGLYLEDELYGRSARQSPSAMGGYNTGMGPTSDRAYLGDLQHQNTDLQRELGNLKRELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQKQAMLVRQLEEELRLRMRQPNLEMQQQMEAIYAENDHLQREISILRETIKDLECRVETQKQTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLPDIIGQYYGPGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRRYSIAGLPSATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTPLGGGGVGMGLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTAAQSAAAAAARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQSLHASNPAISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQMHPQYQYHVHQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHHSHHTAYPHSHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEHKRQLDEFRLEIQRRDQEILAMAAKMKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLERSQNVQKLMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQSDAERAREEAAALQEKLEKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFSEVEKIKEEMERTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDKLDKACTENRRLVLEKEKLTYDYDNLQSQLDKALGQAARMQKERETLSLDTDRIREKLEKTQVQLGRIQKERDQFSDELETLKERSESAQTLLMKAARDREAMQTDLEVLKERYEKSHAIQQKLQMERDDAVTEVEILKEKLDKALYASQKLIDEKDTSNKEFEKMLEKYDRAQNEIYRLQSRCDTAEADRARLEVEAERSGLAASKAREDLRKLQDESTRLQEACDRAALQLSRAKECEDNARSELEHSRDRFDKLQTDIRRAQGEKEHFQSELERVTYELERAHAAQTKASASVEAAKEEAAHYAVELEKMRDRYEKSQVELRKLQDTDTFGRETRRLKEENERLREKLDKTLMELETIRGKSQYESESFEKYKDKYEKIEMEVQNMESKLHETSLQLELSKGEVAKMLANQEKQRSELERAHIEREKARDKHEKLLKEVDRLRLQQSSVSPGDPVRASTSSSSALSAGERQEIDRLRDRLEKALQSRDATELEAGRLAKELEKAQMHLAKQQENTESTRIEFERMGAELGRLHDRLEKAEAEREALRQANRSGGAGAAPHPQLEKHVQKLESDVKQLAMEREQLVLQLEKSQEILMNFQKELQNAEAELQKTREENRKLRNGHQVPPVAAPPAGPSPAEFQAMQKEIQTLQQKLQESERALQAAGPQQAQAAAAAGASREEIEQWRKVIEQEKSRADMADKAAQEMHKRIQLMDQHIKDQHAQMQKMQQQMQQQQQAAQQAVQQAAQQQQSAAGAGGADPKELEKVRGELQAACTERDRFQQQLELLVTELEKSKMSNQEQAKQLQTAQQQVQQLQQQVQQLQQQMQQLQQAASAGAGATDVQRQQLEQQQKQLEEVRKQIDNQAKATEGERKIIDEQRKQIDAKRKDIEEKEKKMAEFDVQLRKRKEQMDQLEKSLQTQGGGAAAAGELNKKLMDTQRQLEACVKELQNTKEEHKKAATETERLLQLVQMSQEEQNAKEKTIMDLQQALKIAQAKVKQAQTQQQQQQDAGPAGFLKSFF
Protein: Ankyrin repeat-containing protein C6C3.08 (Q10311)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- 26S proteasome regulatory subunit 8 homolog
- Probable 26S proteasome subunit rpt4
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit rpn10
- Probable 26S proteasome regulatory subunit rpn6
- 26S proteasome regulatory subunit rpn2
- Probable 26S proteasome regulatory subunit rpn9
Sequence:
MVYASLGKAIEENCPEEYVEQAIQNDPNSLNAVDDDKRTPLHWACSVGKVNTIYFLLKQPNIKPDEKDEAGWTPLMISINNRSVPDNVIEELINRSDVDPTITTRGGQTCLHYAAGKGRLSIVQLLCDKAPELIRKKDLQGQTPLHRAAAVGKIQVVKYLISQRAPLNTSDSYGFTPLHFALAEGHPDVGVELVRAGADTLRKDSENHTALEVCPDRIVCNEFLEACKEQNLEI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (E1B9D1)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
MNEVSVIKEGWLHKRECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGDDPMDYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITVTPPDRYDSLGSLELDQRTHFPQFSYSASIRE
Protein: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein homolog) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) (A0A8C2MDK8)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5NCQ5}. Cytoplasm {ECO:0000250|UniProtKB:Q5NCQ5}. Note=Punctate, primarily perinuclear localization. {ECO:0000250|UniProtKB:Q5NCQ5}.
Interaction partners:
Sequence:
MAALVVSETAEPGSRVGPGRGRISRGRLANQIPPEILNNPQLQAAVQALPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTKAEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFAPGSSLALVSTIQFVSTLQAAAQELKAEYHVSVPQCKPLSPGEILGCTSPRLPKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQATRQEAIAAARSAKTWGLILGTLGRQGSPKILEHLESRLKGLGLPFVRLLLSEIFPSKLSLLPMVDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKDISWQQPYPMDFYAGNSLGPWTVNHGRDPGPRGLGQPASGKVQQGFRGQSPAPACEGCSCADLKAALPAS
Protein: Sex-determining transformer protein 2 (Cbr-Tra-2A) (Cbr-tra-2) (Q17307)
Organism: Caenorhabditis briggsae
Function: Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development (By similarity). In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1 (By similarity). Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also required for feminizing tra-3 activity (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Sex-determination protein fem-3
- Protein CBR-HER-1
- Sex-determining transformer protein 1
- Protein CBR-GLD-1
- XO lethal protein 1 homolog
- Protein CBR-TRA-3
- Protein CBR-FEM-2
- FOG-3
- RNA helicase
Sequence:
MKLAFNKLLVASVVFTVLSFGLLLASLFTTTATTPSEWTILLPEFRFPVNKKQTTEQFLVEKIVHEHEEGEDVRSALYLTHHGYFMNAIANMKVTYRQKSYTVNDVCFKPHSAIFENVPAPENIDKLPAYFQRLLLEMQRLSPCLIVTPLNCFYDSYHIHSEISNWNASTDYLNRRLRNSYLEAIEEKDSRPYVKSTYGPELIKEWARHMFAIPSKPLSNFSKSDLYSRVKTWLSSIAARKKICADPMRSCDETLDAENYFNVCTVMQQINDYDERRKQRLKFQLEYGDEEFTTRLDCVEDREKFIEWMQERNLRDMLKLFASSVEIPDHKEIPNQVCDGIYHDLDTSSGLELFRGARSFSNNTSAYDTINVELGFMTPENLLTTMRHSDFVNGFESIWTIERARELLNEFRLALKVEVTKFSESRSSRRVKVTTRIVNQIEEEGSDEEMEYHMIYFILGACALMVALFAAFAFSEAFLTSLSMFLLRGFITGLLFIFLCKSGGLILIDSNFLCYITMHLAFNLVMTARVTFICYRIGGCVQSEKDFVKSNFSSLGSVPVDSLKEDSCKRHVQYVLAKYTKFQVAQDAYSEEPFEKLPKYWFLIAIVLVPVIGVYWFFIDSDVQKICIVLLPAFLIAAFEEMRVKNQLLRERRIKKAIQRLQKEENTRIMSRGEIDNLLSGNAELSGEKSHYESKQGVLHHGSAGGLFELSRSTYDVSLIMAYPNQMIRNLRLCALGAYFRLFKMKYCAVVVSSVAALLILLSIGLLFIPVQRSSVPKELQQDELSIDFAIPNVSSSSWESINEYLEEFNSEIDSITNLQTITNGRRVLINSTSKINNFLKWVDDEPISWYLTAPLTRPYRKTHLPNPFRFQFRYGFDSIQKSTIIDVVERIDTLLTKYTETLSFPKAIGFLYEHYHQKAVVWNSFAYHEIFAAAVLAGFFSIIVVFFSIGPVVLPTLAFAFFVVGNRLEIAAIVSLFSLEYHQCYTNVAVFVGFLAAWTPFCDLARFRGRLLYKDQTRRTPELATQRRIRVPHVAAVDTVQIFAIFLTATILLIVITAIIPQFRAFFIPTVILLITLLLAVFNSLAVSLAAYQMFEHEVRHCYHDQLQSLTTTGKVCDMTRKKLLPREEDLSIPMEEFSIRPTENTKHYAPRPIDNSDPPEQAADEEVVNQDPSMEAARRQYVEFTHRTTGMPIELINQFVDNFPVFNVPANFLPNYFALGGAPLDANNGVLLRQPGIAPPPRPNREEDEEERFGLGGGEDDDSYPSSGDDIGDPAKEQQEVTDDVATRYKEEEVRKKVQPAVPNYDDPNVPGPSNPVPRQVEQVSREAPEDSPNREPRILVYQRPPRLHEIPQISHGRNPLHDPPSMEEYVQKYDDPNQPPSRRADQYPPSFTPAMVGYCEDVYWKYNERNLPDNVPMPPRPRDWDQRRLVELPPPEDFDEVPPPGRSAIPIPPGAIRLRERRREQHLREQEARRNRPESPDDTPGL
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (NADH-ubiquinone oxidoreductase B14 subunit) (O18236)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- Probable NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- Probable NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
Sequence:
MSATAGRVVRAGQHAVRTVAPIKSNNSAEARMSVLAAYKEFQRLTPKFWWDFGLHDMPLGVFRAVIKKQFTKNGHLTDVRVVDRLVGETHQHMKSIRYAFYNPDHVRNYLFAENVEAKPKDFLSKFLNGKE
Protein: Branched-chain-amino-acid aminotransferase (EC 2.6.1.42) (M0QXF9)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
IWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYQEQIMAFLIEALESGLSVLLCGLENPLGLNHPFLGAPGALDMSSALETPSCDPLRLLGALYGIRAHEWMFPV
Protein: E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110) (P08393)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: SUMO-targeted ubiquitin ligase that plays an essential role in nuclear antiviral defense evasion triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML, SP100 and MORC3. Prevents antiviral response to viral DNA induced by IFI16 by degrading it. Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells. Interestingly, the E3 ubiquitin ligase activity associated with the RING finger domain does not seem to be directly required to inhibit the activation of IRF3 but instead plays a critical role in modulating the cellular localization of ICP0. Upon reactivation of latent genome, suppresses the silencing of viral DNA by dissociating either HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex localized at the ND10 structures and causes their dispersal. Two cellular histone ubiquitin ligases RNF8 and RNF168 are also targeted by ICP0 for degradation, leading to a loss of ubiquitinated forms of H2A, a relief of transcriptional repression, and the activation of latent viral genomes. Enhances the localization of host CCND3 to ND10 bodies that serve as precursors of replication compartments to enable efficient viral replication. Like many RING-finger E3 ubiquitin ligases, ICP0 can induce its own ubiquitination, an activity that promotes its instability due to its targeting to the 26S proteasome for degradation. ICP0 restricts this process by recruiting the cellular ubiquitin-specific protease USP7 that cleaves the anchored ubiquitin chains from ICP0, thereby promoting its stabilization.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:20454685}. Host nucleus {ECO:0000269|PubMed:20454685}.
Interaction partners:
Sequence:
MEPRPGASTRRPEGRPQREPAPDVWVFPCDRDLPDSSDSEAETEVGGRGDADHHDDDSASEADSTDTELFETGLLGPQGVDGGAVSGGSPPREEDPGSCGGAPPREDGGSDEGDVCAVCTDEIAPHLRCDTFPCMHRFCIPCMKTWMQLRNTCPLCNAKLVYLIVGVTPSGSFSTIPIVNDPQTRMEAEEAVRAGTAVDFIWTGNQRFAPRYLTLGGHTVRALSPTHPEPTTDEDDDDLDDADYVPPAPRRTPRAPPRRGAAAPPVTGGASHAAPQPAAARTAPPSAPIGPHGSSNTNTTTNSSGGGGSRQSRAAAPRGASGPSGGVGVGVGVVEAEAGRPRGRTGPLVNRPAPLANNRDPIVISDSPPASPHRPPAAPMPGSAPRPGPPASAAASGPARPRAAVAPCVRAPPPGPGPRAPAPGAEPAARPADARRVPQSHSSLAQAANQEQSLCRARATVARGSGGPGVEGGHGPSRGAAPSGAAPLPSAASVEQEAAVRPRKRRGSGQENPSPQSTRPPLAPAGAKRAATHPPSDSGPGGRGQGGPGTPLTSSAASASSSSASSSSAPTPAGAASSAAGAASSSASASSGGAVGALGGRQEETSLGPRAASGPRGPRKCARKTRHAETSGAVPAGGLTRYLPISGVSSVVALSPYVNKTITGDCLPILDMETGNIGAYVVLVDQTGNMATRLRAAVPGWSRRTLLPETAGNHVMPPEYPTAPASEWNSLWMTPVGNMLFDQGTLVGALDFRSLRSRHPWSGEQGASTRDEGKQ
Protein: Ribose-phosphate pyrophosphokinase 5 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 5) (Q12265)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribose-phosphate pyrophosphokinase 2
- Ribose-phosphate pyrophosphokinase 1
- Ribose-phosphate pyrophosphokinase 4
- Ribose-phosphate pyrophosphokinase 3
- Amidophosphoribosyltransferase
- Orotate phosphoribosyltransferase 2
- ADP-ribose pyrophosphatase
- Transketolase 1
- Orotate phosphoribosyltransferase 1
- Transketolase 2
Sequence:
MSMSNIVVFGGDSHPELVTKICENLDIHPSKVELGKFSNGETNIALRESVREKDVYIIQSGCGQVNDTFMQLLILISACKSASASRVTAVMPYLCYSRQPDIPYTAKGAPIISKPKENYTFESHPGTPVSSSLMTQRPGAESSLKSLDSAIRSTINLENPQPIRTPNSSATANNNFDIKKTLSFSRIPMIPGGKLQNTSNSTDAGELFNAQNAGYKLWVVQAGTLIAHLLSAAGADHVITMDLHDPQFPGFFDIPVDNLYCKPIAQNYIQHRIPDYQDAVIVSPDAGGAKRATAIADALELSFALIHKERRSQLLKGPPDATLTSGGSLPVSPRPLVTTLVSSQNTTSSGATGVAALEMKKTTSTSSTSSQSSNSSKFVQTTMLVGDVRNKVCIIVDDLVDTSYTITRAAKLLKDQGSTKVYALITHGVFSGDALERIGQSSIDKLIISNTVPQDRTLQYLGKDRVDVIDVSCIIGEAIRRIHNGESISMLFEHGW
Protein: Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15) (Q21955)
Organism: Caenorhabditis elegans
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for regulated expression of genes controlling fatty acid desaturation by transcription factors including sbp-1 and nhr-49. Involved in the response to simulated microgravity, in concert with sbp-1, probably acting in the intestine.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Sterol regulatory element binding protein sbp-1
- Nuclear hormone receptor family member nhr-49
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 12
Sequence:
MSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAALLGNTPAGGTPGYRAPVPPDPQPTSAQARNPPVTVATTQASTTPSAPNPPGGLPAPSASATAAVAAAVASFPSPDTSIRPGGQITPGSQAPGGGPTPAPNVPFPNGSSQMNGGPAMGQPPPQMGAPNMGGPPNGYGGYGMMNGPPGSGAPMGGNPYNQQIKKDMDQARPWDPSAHMYQQQPQWGAMPPQQPHGYPGRPMNGQGATPTGPSSVLESLINQPQQYPGHHNQMGPPGDRNVAAQRAAAQQQQQQQQQQQQQRPGMVPNQGMMSSEDQTVYSAKLRNMRGSCDSLRTRARQCRHEGNHEAAHKLEVMLSVLEGKRVVSLEYLNHLEMWIARKQDFLNIAPMSQNQNHMGMNDPMMNGEHAMLGNGQVPNPYGGHPGYGHQQYMGPPPPHMQMHQPPMWHQQQHQQQQRMMPQDHMMMQGGGGPVHGMYRGDMGHDPMTSPVNNHRHAPYPNPAAMRNNMRMPNGPGPIGRDRNSMSGSSMSGPSSGAPSMNPMGTPNQKMGTPGSMGGMSGLDDLNYDDFLPNPTPIDALQPTLHVGQNSMNAGPPVQRSNLNETARKELQILDARFEIDPNHQRHDANHIIVVCKIRNQQFPPLRLVVPTTYPAGNVTVDRAVIDLDAYLYDDLQNSVYERLSRPGLSSITDYLNAWEEQVNQYQNQTSGGLDVAFNVGNDFFYDNLNL
Protein: Cystatin-1 (Cystatin-I) (P84911)
Organism: Capra hircus (Goat)
Function: Inhibits papain, ficin and bromelain with an IC(50) of 0.09 uM, 0.115 uM and 0.113 uM respectively. Has antibacterial activity against Gram-positive bacteria S.aureus and S.hemolyticus, and against the Gram-negative bacterium E.coli. Reduced antibacterial activity against Gram-positive bacterium B.subtilis. No antibacterial activity against the Gram-negative bacterium P.fluorescens.
Interaction partners:
Sequence:
DTHISEKIIDCNDIG