wanglab/gogpt-training-data huggingface dataset:
Protein: Transcriptional adapter 1 (Transcriptional adapter 1-like protein) (Q8IPA1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- histone acetyltransferase
- SAGA factor-like TAF6
- Ubiquitin carboxyl-terminal hydrolase nonstop
- SAGA-associated factor 11 homolog
- Transcription-associated protein 1
- Transcriptional adapter 2b
- SAGA complex subunit Spt7
- Transcriptional adaptor 3, isoform C
- Transcription initiation factor TFIID subunit 9
- SAGA complex subunit Spt20
Sequence:
MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSSRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH
Protein: Eukaryotic translation initiation factor 3 subunit G-1 (Eukaryotic translation initiation factor 3 RNA-binding subunit 1) (eIF-3 RNA-binding subunit 1) (Eukaryotic translation initiation factor 3 subunit 4-1) (Q9W4X7)
Organism: Drosophila melanogaster (Fruit fly)
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit D-1
Sequence:
MPGVETIKSSWADEVELDYGGLPPTTETVENGQKYVTEYKYNKDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGDSKNDKPGPNSQTTMVSEEIIMQFLNSKEDEKANDPLLDPTKNIAKCRICNGEHWSVNCPYKGTAMDTNMMEKKASAAAAAAVDAPKSGKYVPPFLKDSQKGALGMRGRDDTAAIRISNLSESMTEADLEELVKKIGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN
Protein: Docking protein 6 (Downstream of tyrosine kinase 6) (Q2MHE5)
Organism: Mus musculus (Mouse)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity).
Interaction partners:
Sequence:
MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQPPLSRSSSYGFSYSSSLIQ
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (D3ZBS9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- AT-rich interaction domain 1A
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
- Actin-like protein 6A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Double PHD fingers 2
- Bromodomain containing 7
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- AT-rich interactive domain-containing protein 2
Sequence:
MAARAGFQSVAPSGGAGASGGAGVAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLEDSALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVAEAARIRASPGNPKHIGPPWP
Protein: Race-specific elicitor A4 (Q00363)
Organism: Passalora fulva (Tomato leaf mold) (Cladosporium fulvum)
Function: This necrosis-inducing peptide induces a hypersensitive response on Cf-4 tomato genotypes. Race-specific elicitors are compounds which only induce defense responses in genotypes of host plants which are resistant to the pathogenic race that produces the elicitor, but not in susceptible genotypes.
Interaction partners:
Sequence:
MHYTTLLLSTLLVGTALAQPTNPPAKTPKKAPKTQPYNPCKPQEVIDTKCMGPKDCLYPNPDSCTTYIQCVPLDEVGNAKPVVKPCPKGLQWNDNVGKKWCDYPNLSTCPVKTPQPKPKKGGVGGKKASVGHPGY
Protein: LD36273p (Sniffer, isoform A) (Sniffer, isoform B (EC 1.1.1.184)) (Q9W3H4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Neuropathy target esterase sws
Sequence:
MNSILITGCNRGLGLGLVKALLNLPQPPQHLFTTCRNREQAKELEDLAKNHSNIHILEIDLRNFDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLDTLQTNTVVPIMLAKACLPLLKKAAKANESQPMGVGRAAIINMSSILGSIQGNTDGGMYAYRTSKSALNAATKSLSVDLYPQRIMCVSLHPGWVKTDMGGSSAPLDVPTSTGQIVQTISKLGEKQNGGFVNYDGTPLAW
Protein: L,D-transpeptidase 4 (LDT 4) (EC 2.3.2.-) (Ldt(Mt4)) (O07436)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.
Interaction partners:
Sequence:
MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI
Protein: Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (Prostaglandin H2 synthase 1) (Prostaglandin-endoperoxide synthase 1) (Q8JH44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Interaction partners:
Sequence:
MRECNFLLKWTVILLLSVSFCAGEESPTSSNTANPCCYYPCQNQGICVRYGLERYECDCTRTGYYGENCTIPELWTRVYRLLKPSPNVVHYILTHFDWLWDLINRSFLRDWLMRKVLTVRANLIPSPPTYNSRYDYLNWEAYSNITYYTRILPPVPNDCPTPMGTKGKIKLPDPKLLVEKFMLRRNFRLDPQGTNLMFAFFAQHFTHQFFKTHNRVGLGFTKGLGHGVDAGHIYGDSLDRQLELRLHKDGKLKYQVLNGDIYPPTVLHAQVKMSYPPSVPPEQQLAIGQEVFGLLPGLGMYATLWLREHNRVCEILKQEHPTWGDEQLFQTARLIIIGETIRIVIEEYVQHLSGYRLKLHFDPTLLFNSQFQYQNRISVEFNQLYHWHPLMPDSFYIDGDHIQYSKFIFNTSILTHYGLEKLVEAFSIQPAGQIGGGHNIHPVVSGVAERVIVESRELRLQPFNEYRKRFNLKPYTSFAELTGEQEMSKELEELYGHIDAMEFYPALLLEKTRPGAVFGESMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGKTGFDIVNSATLKKLVCLNTKWCPYVSFHTPPSDYKPQRTSHGEL
Protein: Auxin-responsive protein SAUR23 (Protein SMALL AUXIN UP RNA 23) (Q9FJF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as positive effectors of cell expansion through modulation of auxin transport.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9FJG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9FJG1}.
Interaction partners:
- Auxin-responsive protein SAUR62
- Auxin-responsive protein SAUR61
- Auxin-responsive protein IAA2
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA11
- Auxin-responsive protein SAUR65
- Auxin-responsive protein SAUR63
Sequence:
MALVRSLLVAKKILSRSAAAVSAPPKGFLAVYVGESQKKRYLVPLSYLNQPSFQALLSKSEEEFGFDHPMGGLTIPCPEDTFINVTSRLH
Protein: Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27) (A6NNY8)
Organism: Homo sapiens (Human)
Function: Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI. Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling. Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1. Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization. Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (By similarity). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CEG8}. Nucleus {ECO:0000250|UniProtKB:Q8CEG8}.
Interaction partners:
- Ataxin-7-like protein 3
- Transcription and mRNA export factor ENY2
- SAGA-associated factor 29
- Transformation/transcription domain-associated protein
- Transcription initiation protein SPT3 homolog
- Transcriptional adapter 3
- Ubiquitin carboxyl-terminal hydrolase 51
- Transcription initiation factor TFIID subunit 12
- Transcriptional adapter 2-alpha
- Transcription initiation factor TFIID subunit 6
Sequence:
MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY
Protein: Centrin-3 (Q8IJC7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Thioredoxin-like protein
- NADH-cytochrome b5 reductase, putative
Sequence:
MINRKSESVSYTPRAITNRPISSNRRRGRNEITDEQKNEIKEAFDLFDTEKTGKIDYHELKVAIRALGFDIKKADVLDLMREYDKTNSGHIDYNDFLDIMTQKISERDPTEEIIKAFKLFDDDDTGKISLKNLRRVSRELGENLSDDELQAMIDEFDKDMDGEISQEEFLSIMKQTSLY
Protein: Neamine transaminase NeoN (EC 2.6.1.93) (Glutamate--6'-dehydroparomamine aminotransferase) (Neomycin C transaminase) (EC 2.6.1.95) (Neomycin biosynthesis protein 18) (Neo-18) (Neomycin biosynthesis protein B) (Neomycin biosynthesis protein N) (Q53U08)
Organism: Streptomyces fradiae (Streptomyces roseoflavus)
Function: 6'-oxoglucosaminyl:L-glutamate aminotransferase that catalyzes pyridoxal-5'-phosphate-mediated transamination for the conversion of paromamine to neamine in the biosynthetic pathway of neomycin. Also able to catalyze deamination at C-6''' of neomycin.
Interaction partners:
Sequence:
MTKNSSLLAEFPTCPRDEKDRPRVFTAASGAWLTDESGFRWIDFDNARGSILLGHGDPVVAEAVARAATGADGTATGWSRRVDAVLERLHALCGGEVVGLFRSGTAAVRAAVLAVREATGRPLLLSAGYHGYDPMWYPSEAPLEPNADGVVDFFFDLGLLRELLRAPERVAAVVVSPDHMHLSPGWYRELRRLCSAAGVVLVADEVKVGLRYAPGLSTAELLAPDVWVVAKGMANGHAVSAVGGSRRLLKPLKEVSFTSFFEPTILAAADAALARVATGEPQRAVREAGDRFLRHARKALDDASLPVEIAGDGTFFQFVPATEELEEALYGAANAEGLLFYAGDNQGVSAAFDEAVLGEAERRFARVCERLAPYAGGEPVGDAARYRVAWNVMDGLRQAPRDREETTGLLARLLDD
Protein: Eukaryotic translation initiation factor 4E-1A (eIF4E-1A) (mRNA cap-binding protein) (Q9DFS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14701818}. Nucleus {ECO:0000269|PubMed:14701818}.
Interaction partners:
- Eukaryotic translation initiation factor 4E-binding protein 3-like
- Cytoplasmic FMR1-interacting protein 1 homolog
- Eukaryotic translation initiation factor 4E-binding protein 1
- Eukaryotic translation initiation factor 4B
- Cytoplasmic FMR1-interacting protein
- Eukaryotic translation initiation factor 4, gamma 2b.
- non-specific serine/threonine protein kinase
- MAPK-interacting serine/threonine kinase 2a
- MAPK-interacting serine/threonine kinase 2b
- Eukaryotic translation initiation factor 4 gamma, 3b.
Sequence:
MATAEPETSTNPSNSEEKNEENEQQIVSLEDYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMSGCDYSLFKDGIEPMWEDERNKRGGRWLITLSKQQRRADLDRFWLETLLCLVGEAFDDHSDDVCGAVVNIRTKGDKIAIWTTDYENKDAIVHIGRVYKERLGVPPKVIIGYQSHADTATKSGSTTKNKFVV
Protein: Large ribosomal subunit protein uL5 (50S ribosomal protein L5) (P9WH83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Interaction partners:
- Small ribosomal subunit protein bS18A
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein bL19
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein bL34
- Small ribosomal subunit protein bS6
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein uL23
Sequence:
MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNMGVGEAARDAKLINGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMWEFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMDINVVTSAATDDEGRALLRALGFPFKEN
Protein: Histone-lysine N-methyltransferase set-26 (EC 2.1.1.355) (Q9U263)
Organism: Caenorhabditis elegans
Function: Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together with spr-5, required for transgenerational fertility.
Subcellular location: Nucleus {ECO:0000269|PubMed:22212395, ECO:0000269|PubMed:29714684}.
Interaction partners:
- JmjC domain-containing protein
- Bromo domain-containing protein
- C2H2-type domain-containing protein
- DEK_C domain-containing protein
- Protein sumv-2
- Lysine-specific demethylase 4
- Histone-lysine N-methyltransferase set-25
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
- MYND-type domain-containing protein
- SET domain-containing protein
Sequence:
MADGEHTLPADEELFEQPPLQQQQPEIAEPIVMAQEPIQGVSEDPQASEATHEAPDNYPVDHQMENQEFYQEPQIPEPQQIPQIPVFQPAAYNPPNYVAPQQRANNFGEPAAAADSRPLTEEEQLAAERPTEDTVWIDSDDDTDVEEAILRANFWLPYSDHNYDPPDPADRIILPTEGPFPCIAGLDEDCNIVKQWMPEDAVGPGSPGTQYRRNQQTGGGLPSTSVAPQQQQLPVRHNIQNRPMVAAQPFSIGGNQVEYGGIGGMDSRMQQRGVVRDGPQYRVMNDFGNGLPMRGQLPPRNSPAANAINRVREQQQQMYHQAGARGSLQQRVPAPAAPTPGSYQHIVNAVPVGGANPMRRVPPQARPGMIGGAANNNRARPIHVTRPMDTQEFEHPVAPAAAAPPRRVVDVAPHRMTPEQRQELQQMNRQRAAPQFPAAAAQRSAEKIVIQQRPGASSSRAPRPSMAQEDLLRSPTRRLSERVPQEHQTPVLEPRRFQVKVTDTYSTPIPKASDQLPAQLTEEDPPEESAAAAAPEDVPDAAPEDPPKGILKPTPPHRMTQEEKNAHFARLTTDKEKPTSSASILPQDAAPPHVPPPPPPPLVLRPHHQDETLAMVQSVFESKPRQPDTPKDKEAISKIADLLRFSADEFTGQSGSSAAARQRTVSGSAARAQTYQMHHQQQQQHHHQMPMDQRKRHSSGRYDALMGAMPLQQQPPPPPPSQFQHTDSIAHRPRGRPKGTRHPSVAVQPQRSGGARTLPPRAQTVAMSARNGANAKNSDSESEGIDEAAEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSKYKCEMCLPRRLPVSKAEAAREQERILNRLRAAAKKQKRKSEPVEQKQKSQPSTSRKSAPMALQQQPAEPRVAQLNDYSKQASALLFGMEQTAGADTLLAESRLHKKARRMFVEEAVEALVTTDLVQIRQVILEVNGHVSMSNEVKRQPGGGNCIFMYDGLMKGTAGEDMGDGQELVCIDTKRKGNDTKFTRRSCVPNCVLKHVLGSNATLGIMIVATKDITRNTEVTLPFDADWRESEVELECAEHMKELQACPFESERRRFAAERHRAMDHKKREAEEARRADEERRRLEEEVRRERAAKTKQMDEAEKARLEAEKAAEKEKKAKEREEAKERKKMEVEASAAAAPESSNSITAREERRIQQAEEMFRRQEEEGKRKEARRRSKSVTPGVLEAAGTAAREDAPEASIPAPAPSPPASRRSVSRTTQPSTSSFATPTEPPAKNKRMRSVVPPKSEPASSAKRVRATTVATPKDTTASNDSRKRKSSATGKTPVAKRSKNVVPTSFGLALIEKELREQARDSTVLEMILPDYIMKEKRSGLLAGQSPDFSEVRAQIEEENRMKERFTKREAKKKAVEKAKEKEKKEHRKEPKKANEPGPAPKSEKAVEKAVEKVEKKPKSPQKPPAKPTAQKPPLKKTEEVDGIEREASESSSKESSVAPEEKKNPKKITFAEYNSRRSQKREAGECSTPPAVTRRGFIPSTEGEDLVNVELSAIPLDDHPSSSNTAPTTTIAPSVGGAPKPTSVVVKSPSTRSRTRGAASESVDDAPAEHSMSLQDRVFSMFGSTVDAPAPPPPPPASAETNSRRSRSTRWN
Protein: Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5) (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5) (Q9WUZ9)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:10369669}. Secreted {ECO:0000250|UniProtKB:O75356}.
Interaction partners:
- Ectonucleoside triphosphate diphosphohydrolase 4
- Ectonucleoside triphosphate diphosphohydrolase 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleoside triphosphate diphosphohydrolase 8
- Ectonucleoside triphosphate diphosphohydrolase 1
- Adenylosuccinate synthetase isozyme 1
- AMP deaminase 3
- Inosine triphosphate pyrophosphatase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Uridine 5'-monophosphate synthase
Sequence:
MATSWGAVFMLIIACVGSTVFYREQQTWFEGVFLSSMCPINVSAGTFYGIMFDAGSTGTRIHVYTFVQKTAGQLPFLEGEIFDSVKPGLSAFVDQPKQGAETVQELLEVAKDSIPRSHWERTPVVLKATAGLRLLPEQKAQALLLEVEEIFKNSPFLVPDGSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAKGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEVRGSAFYAFSYYYDRAADTHLIDYEKGGVLKVEDFERKAREVCDNLGSFSSGSPFLCMDLTYITALLKDGFGFADGTLLQLTKKVNNIETGWALGATFHLLQSLGITS
Protein: Protein strawberry notch homolog 2 (Q9Y2G9)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade.
Interaction partners:
Sequence:
MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMSSASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDMLRSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL
Protein: Uncharacterized protein, isoform A (B7Z088)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGGGFAAPPITLASNQRPVALDQVEIPIPATDMHEKLLEKEGKTERTNLLGRSKDKPPKDKPPKQSKFAERLRRSFRRGDHRSLEIKRQEPTPEELKAKSRATPPPPSTLRSDNNNRLPFALSHLNLPGLGLGVGVGVGGHINPALLLDSPDECTPPEYAYQHLSSVATTNSSTSLESSCELGELSGSQNSVYYWASMGGEVSTSAGAAGADGTAGTGAGTGAGAGAAVPIEGQDRRRLETQNSSRSDQQPITTNASSAPGNSSRSCSLTSDSSSIRLTRLQNFLFKSSNESSRSCQGHSNEGFTVSSHNSSSGEWEQLGAYLSSSSGVGGGHDFQGGSFPEESTPDETDGTLPVETSSSGGGGGYYQYTLTSPNNPFLPEITARTYHSTYGEDGAVEGGEPTTDDLQLDGKYGCAGSRSAQLPTPSYSRAGSQESTHSEGGGPPGPTPSPASSSSSTPGRHRRKLFSLNSPTRLLHHQQQQPPPSGATSASPPSGGSSNDGGGGKFNSASLVRSLNPFLPSVTSPKKAPHKQSAVTSPGCLTPDLSTKREEFLRATMKICLVVSPPNSKLQLKSKSLTHLDGLDSGVVACQQGPPGMATSTASTTATTAGGTGATTGLFATTGAPGSLGRQANVTEKGERTGVCLSPSAPQPSSHASPHHPPTIYTQAPQVVRRMPSLMLSPTLDETTTTASSSCFGTGHPSAGSFHQHQHHHHHHQPTGSVSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSSSTLSPHSATSATLGGGGGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVESLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCTEAKNWYDALWRAKTIYQRLKRGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNHLGQSLPNLNMHHSHTVPLRRGMAFSTSTKNPPLRKTRNITSQNSINWHQIPATPTPPSPRSQYQSPGVVCMQKSLPLLLPTNTDEGQGPTQPPPPLQKQLSHQAPLPTTIHNQSSTETDV
Protein: U17-myrmicitoxin-Mri1b (U17-MYRTX-Mri1b) (A0A6G9KHE5)
Organism: Manica rubida (European giant red ant)
Subcellular location: Secreted {ECO:0000269|PubMed:32182430}.
Interaction partners:
Sequence:
MENSRTSTFTAYVTVAFLLISTFVTMVVTESQIVWVPCNPRSKKTDDAGICRNTY
Protein: Putative uncharacterized protein encoded by RHPN1-AS1 (RHPN1 antisense RNA 1) (RHPN1 antisense gene protein 1) (Q9BWJ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPAFFSLPAERRLQAWPQSEAPLSVSSCFQNRPPEPASFQNLRPEPASLQNLRTEPTSF