wanglab/gogpt-training-data huggingface dataset:
Protein: Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270) (Q92956)
Organism: Homo sapiens (Human)
Function: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19915044}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- B- and T-lymphocyte attenuator
- Lymphotoxin-alpha
- Tumor necrosis factor ligand superfamily member 14
- CD160 antigen
- Atypical chemokine receptor 1
- TNF receptor-associated factor 5
- TNF receptor-associated factor 2
- Syncytin-1
- Tumor necrosis factor
- Nectin-1
Sequence:
MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAPALPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVWWFLSGSLVIVIVCSTVGLIICVKRRKPRGDVVKVIVSVQRKRQEAEGEATVIEALQAPPDVTTVAVEETIPSFTGRSPNH
Protein: Cadherin 5 (H3BPG1)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENL
Protein: AT3g61540/F2A19_140 (Alpha/beta-Hydrolases superfamily protein) (Prolyl aminopeptidase-like protein) (Q9M314)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Leucine aminopeptidase 2, chloroplastic
- Proline iminopeptidase
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Aminopeptidase
- Receptor-like protein kinase HERK 1
- G-type lectin S-receptor-like serine/threonine-protein kinase RLK1
Sequence:
MLATHALVTPIPKLTAFVLSLSTTPSRLSGSVPGLIDFYRRRRFCRVITSMAEAGSVYVDVAGESKSEHVTGKWFSVPELRLRDHRFIVPLDYSKSSPKITVFAREIVAVGKEEQAMPYLLYLQGGPGFEGPRPSEASGWIQRACEEFRVVLLDQRGTGLSTPLTCSSMLQFKSAKELADYLVHFRADNIVKDAEFIRVRLVPKADPWTILGQSFGGFCALTYLSFAPEGLKQVLITGGIPPIGKACTADDVYEAGFEQVARQNEKYYKRFPQDIEIVRELVNYLAESEGGGVPLPSGGILTPKGLQTLGLSGLGSSTGFERLHYMLERVWDPILVTGAPKCISQFFLNAFESWHSFDTNPLYALLHEAIYCEGASSGWSAHRLRDKYEYKFDAMKAVKESQPVLFTGEMIFPWMFDEIHALKPFKAAADLLAKKEDWPPLYDVPRLQNNKVPVAAAVYYEDMYVNFKLVTETASHISGIRLWVTNEFMHSGLRDAGRQIIDHLLGMINGKKPLF
Protein: BAF chromatin-remodeling complex subunit BCL11A b (BCL11 transcription factor A b) (A2BE84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ubiquitin specific peptidase 34
Sequence:
MSRRKQGKPQHLSKREFSPEPVTADIPEDGESNPGSEPSTPKGDQDLLTCGQCRSRFPLADILVFIEHKRRQCQGRLCMDKSSDLPPSPPPAGLRRACIPVEVAVQVSPHGEERLASTPHGLRPKQENLSEKDEPSSYTCTTCKQPFSTAWFLLQHAQNTHGFRIYLESEPGSPLTPRVASAPGMGGDCASQPPIHAAHLGDSSPYSLMRIANRDGSSVPREGRYPRTPPLFSPPPRHHMSPDDLALAPHHPSAFDRVLRLNSVPLDSPSMDFSRRLRELAGNSAGSSPPMSPNRPSPMQRLLQPFQPGASHSPSGPRSTPTQQTPTLPTAKAKSCEFCGKSFKFQSNLIVHRRSHTGEKPYKCHLCNHACTQASKLKRHMKTHRHKSSSTTSKSDDGLSTASSPEPGTSDLPSSATNALKSVVAKFKIENNGMIPENGQEEDEEEEEEEEDEEEEEEEEDEEEEEEEEENESEAGERNDINFSLSLEGARHHENNRQRHNKNVEGIQDYREALKHYKRGDHHRSAHETFGDSSPKESSQVNEGYGHIVNGSASYSNDDLSRKLLAGSPGSDSPLTKRIKVEKDLDLPTPTIPNSENVYSQWLAGYAASRQLKDPILNFGDSRQSPFATSSEHSSENGSLRFSTPPGELDGGTASGRSGTGSRASTPHLPSGRPSSKDGRRSDTCEFCGKVFKNCSNLTVHRRSHTGERPYKCELCSYACAQSSKLTRHMKTHGQTGKDVYKCEICHMPFSVYSTLEKHMKKWHNDRPLSIEIKSE
Protein: Heptaprenylglyceryl phosphate synthase (HepGP synthase) (EC 2.5.1.n9) (Glycerol-1-phosphate heptaprenyltransferase) (Q53726)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranylgeranyl diphosphate (GGPP; C20) as the prenyl donor.
Interaction partners:
- ATP-dependent DNA helicase PcrA
- CamS family sex pheromone protein
- DNA ligase])
- DUF1405 domain-containing protein
- His repressor
- YlbF family regulator
- Cytosolic protein
Sequence:
MYDIKKWRHIFKLDPAKHISDDDLDAICMSQTDAIMIGGTDDVTEDNVIHLMSRVRRYPLPLVLEISNIESVMPGFDFYFVPTVLNSTDVVFHNGTLLEALKTYGHSIDFEEVIFEGYVVCNADSKVAKHTKANTDLTTEDLEAYAQMVNHMYRLPVMYIEYSGIYGDVSKVQAVSEHLTETQLFYGGGISSEQQATEMAAIADTIIVGDIIYKDIKKALKTVKIKESSK
Protein: NADH-quinone oxidoreductase subunit K (EC 7.1.1.-) (NADH dehydrogenase I subunit K) (NDH-1 subunit K) (NUO11) (P0AFE4)
Organism: Escherichia coli (strain K12)
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- NADH-quinone oxidoreductase subunit J
- NADH-quinone oxidoreductase subunit M
- NADH-quinone oxidoreductase subunit L
- NADH-quinone oxidoreductase subunit B
- NADH-quinone oxidoreductase subunit N
- NADH-quinone oxidoreductase subunit G
- NADH-quinone oxidoreductase subunit I
- NADH-quinone oxidoreductase subunit F
- NADH-quinone oxidoreductase subunit E
- NADH-quinone oxidoreductase subunit A
Sequence:
MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
Protein: 11 protein (Virion protein G11) (O41932)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Interaction partners:
Sequence:
MAESHPWSGRPSSSPRRSSTFANYAWKHTIKPNRILIRNARPLVINFATDRLPIIKPVDQIILEDAGTVGSALNLPSESICTRPGLLLFGHYNNDVPVTPLVDFKPDEPLQVVLTAHKTIVVPPGEFVMIIVCVNFEKIKSLDLIIHEMSTSNIPLPPTCGQTFKNFNTATPSLEIYGDVIECNDDQKTCVFTAVFPGLHRRCSLHGPLNFMGFVNSVNITGTILRVYYSGVSEAAPDSILVKFKTSSAVAFSKNPCQGHVPSHDDTLIPLVYTGPTLRLLPLETISIPFNTSFVAQNPDLKAIIYDNNLKDIRISATMWTGEQTPILAHNLTAAVKLIHSGTVFARAAFFSTKENKKACTLKLCPSTILLPGGELSLDTSTLPNCFK
Protein: Serine/arginine-rich splicing factor 1 (Q8I3T5)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine/arginine-rich splicing factor 4
- Serine/arginine-rich splicing factor 12
- Alternative splicing factor ASF-1, putative
- RNA-binding protein, putative
- U1 small nuclear ribonucleoprotein 70 kDa homolog, putative
- RNA helicase
- Transportin
- RNA-binding protein 8A, putative
- RNA-binding protein, putative
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MVIRESVSRIYVGNLPSHVSSRDVENEFRKYGNILKCDVKKTVSGAAFAFIEFEDARDAADAIKEKDGCDFEGNKLRVEVPFNARENGRYNARGGGRGMMHRGPKSRRGRYVVEVTGLPISGSWQDLKDHLREAGECGHADVFKDGTGEVSFFNKDDMLEAIDKFNGSIFRSHEGEKSKISIRQKKTLWRRDDGGYGRYNSRHRSYSSRSYSRSGKRSYTRSRSRSYSSRSYSRSRSSSSRSRSRSMDRRRDTYDKKRSYSRSLSYQERRRNNRTISKSRSRSRTNSRSSSWSHKRRH
Protein: Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) (Q99519)
Organism: Homo sapiens (Human)
Function: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Subcellular location: Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Lysosome {ECO:0000269|PubMed:25153125}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Interaction partners:
- Lysosomal protective protein
- Beta-galactosidase
- Alpha-galactosidase A
- Arylsulfatase A
- Galactocerebrosidase
- Galactosylceramide sulfotransferase
- 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
- N-acetylgalactosamine-6-sulfatase
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Lysosome-associated membrane glycoprotein 1
Sequence:
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
Protein: Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (Q6AXH7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSCSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKCSYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
Protein: Nudix hydrolase 25 (AtNUDT25) (AtNUDX25) (EC 3.6.1.17) (Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)) (Q9C6Z2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the hydrolysis of diadenosine 5',5''-P(1)P(4) tetraphosphate (Ap(4)A), a signaling molecule involved in regulation of DNA replication and repair.
Interaction partners:
- Nudix hydrolase 1
- Nudix hydrolase 4
- Nudix hydrolase 11
- Nudix hydrolase 9
- Nudix hydrolase 5
- Nudix hydrolase 10
- Nudix hydrolase 19, chloroplastic
- Nudix hydrolase 3
- Nudix hydrolase 2
- Zinc finger CCCH domain-containing protein 48
Sequence:
MENLPPGYRPNVGVCLINSDNLVFVASRLNVPGAWQMPQGGIEDGEDPKSAAMRELQEETGVVSAEIVSEVPNWLTYDFPPAVKAKVNRLWGGEWHGQAQKWYLVRLRNDEDEKEINLANNEADSEFAEWKWAKPEEVVEQAVDYKRPTYEEVIKTFGSFLNDTGRAAKCKSAKW
Protein: PDZ domain-containing protein (Q8CEX7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEKEEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVMRNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKGDRSPEPGQTWTHEVFSSRSSEVVLNTVQPSSLNCNDQNKPKEAINKAGAASDSTPDAGSAFQPQGSPGLQICLSTLTSSCLALSA
Protein: Long-chain-fatty-acid--AMP ligase FadD23 (EC 6.2.1.57) (FAAL23) (Long-chain fatty acid adenylyltransferase FadD23) (Long-chain-fatty-acid adenylase/transferase FadD23) (P9WQ47)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peptide synthetase MbtE
- Phthioceranic/hydroxyphthioceranic acid synthase
- 2'-acyl-2-O-sulfo-trehalose
- Peptide synthetase MbtF
- Isonitrile lipopeptide synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15
- Mycocerosic acid synthase-like polyketide synthase
- Phenyloxazoline synthase MbtB
Sequence:
MVSLSIPSMLRQCVNLHPDGTAFTYIDYERDSEGISESLTWSQVYRRTLNVAAEVRRHAAIGDRAVILAPQGLDYIVAFLGALQAGLIAVPLSAPLGGASDERVDAVVRDAKPNVVLTTSAIMGDVVPRVTPPPGIASPPTVAVDQLDLDSPIRSNIVDDSLQTTAYLQYTSGSTRTPAGVMITYKNILANFQQMISAYFADTGAVPPLDLFIMSWLPFYHDMGLVLGVCAPIIVGCGAVLTSPVAFLQRPARWLQLMAREGQAFSAAPNFAFELTAAKAIDDDLAGLDLGRIKTILCGSERVHPATLKRFVDRFSRFNLREFAIRPAYGLAEATVYVATSQAGQPPEIRYFEPHELSAGQAKPCATGAGTALVSYPLPQSPIVRIVDPNTNTECPPGTIGEIWVHGDNVAGGYWEKPDETERTFGGALVAPSAGTPVGPWLRTGDSGFVSEDKFFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAIAVPSNGVEKLVAIVELNNRGNLDTERLSFVTREVTSAISTSHGLSVSDLVLVAPGSIPITTSGKVRRAECVKLYRHNEFTRLDAKPLQASDL
Protein: Transcription factor IIIB 60 kDa subunit (TFIIIB) (B-related factor 1) (BRF-1) (TFIIB-related factor) (Q9P6R0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: General activator of RNA polymerase III transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Transcription factor tau subunit sfc4
- TATA-box-binding protein
- Transcription factor TFIIIB component B''
- Probable DNA-directed RNA polymerase III subunit rpc6
- Transcription factor tau subunit sfc1
- DNA-directed RNA polymerase III subunit rpc4
- Transcription factor IIIA
- Transcription factor tau subunit sfc3
- Transcription factor tau subunit sfc6
- DNA-directed RNA polymerase III subunit rpc3
Sequence:
MGCPNCGSTTFESDTASGNTYCTQCGVVVEQDAIVSEVTFGEASTGAAVVQGSLVSNDQTHARTFGGPYRNQGSVESRELTIANGRRRISALAIALKLNERHIEAAVRYFTLAINNNFIKGRRSQYVVASCLYIVCRISKTSHMLIDFSDILQINVFKLGSTFLKLCRVLRPNLPLLDPSLYISRFASLLEFGPETHRVANDAIRLVARMNRDWMQIGRRPAGICGACLLIAARMNNFRRSVREVVHVVKVADITIQKRLDEFKLTESGDLSIADFRNIWLEGQSDPPSFTKNQKFQQYGAQKVSNIDHTQEYMSPIKRTPDFDGNEVKSEELSQTVKVESQETPVHLKADEREIRKEVTETLKGDELRKISLQVNVKFSEEEVTLEDVDDDEIEDILLDKDEILTKTQVWMELNKDYLAEEEAKNLKLQEDLKKGIVRQPRKRRRYRPRDSTSDGIADTAAESAKEMMQQRAFSKKINYEALDMLFDEEQS
Protein: NEK6-subfamily protein kinase (EC 2.7.11.34) (Q5TBG4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPRREVCWEAAHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV
Protein: MI domain-containing protein (Q383K4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cell division control protein, putative
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 19
- G10 protein
- U5 small nuclear ribonucleoprotein component, putative
- PRP8 protein homologue
- Pre-mRNA splicing factor, putative
- Splicing factor YJU2
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- Pre-mRNA-splicing factor SYF1
Sequence:
MSRYIPPHRKRASEVESGNSKGPGDETVQHEAWRALGRSITGIVNRVSGENVELSATELFRENIIRGRGLLCRSLMRAQLVNPDITNVLAALVSRVNKEVSTVGALLCKRLVVQWRRLHRRKDWEGLRCVSRFIGWLYVFNIVNVEVVYQIMLTHLTAEPRTDDDVDQAASLFRETFRSMSQRAVSEFHMHVLTPIRDLLAMDNDEWRLSARAQTLLEGCLHEVQQWERVKHSMSIIPEHLLLVDPTGQNCHEVDLEEVTEAETEEKLDRFVYDSEYEAHEEAYEKVRCAILGDNWEAELLEGIVAAEDADEEEEEGEGAEEQGETQGGVDPSKQLIDERERQIRREVYMAMRSSVRADEVVHKILKSIQPDAERTVCFMVIEGSSEETSYRKIYGMVAERLCKSNTKFQGYFAEAFRLRYTRAEDLEEKQIEYTCKIYVHLLRTDSLPWHKCLSVLDIVENNMSQRLVIQWLLQGLAEAMGMRALIKRFEDDKELRISTHKLFPIDSNTSEEELERAVNMFEAMGLGDLGSKTRGRLEEIRAARRANSSHHYYGASGDPSYCDNQKKPSKRLRDGALEYA
Protein: HHIP-like 1 (HHIP-like protein 1) (F6PEI8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- B2 bradykinin receptor
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
Sequence:
MWYFCDVFGRIWQPPFILFYLSAFWIAPAILHPQCLDFKPPFQPQQELQFCQMYKNFGCCDYARDQELMKKYYRVMDNFDYYGYSNCASYVQDLLCQECSPYAAHLFDAEDPSTPLRTIPGLCPDYCAQFHSKCRSFLTLLSDDPRLAELEHDQRKLCQYLELDDPDYCYPHLLSNEHLNKNLGRTAADSEGCLQLCLEEVANGLRNPLAMVHANDGTHRFFVAEQVGLVWVYLPDQSKLEKPFLNITKAVLTSPWEGDERGFLGLTFHPRFKYNGKLYVYYSVEVGFDERIRISEFRISSTDMNVVDHTSERIILEIDEPASNHNGGQLLFADDGYLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDDNERGPLYRIPADNPFVHEPKARPEVYAYGVRNMWRCSVDRGDPITKEGRGRIFCGDVGQNKYEEVDIVEKGRNYGWRAKEGFSCYDKKLCANSSLDDVLPIYAYPHKMGKSVTGGYVYRGCENPNLNGLYIFGDFMSGRLMSLKENRQTGNWEYNEICMGIGLTCSFPGLINNYYPYIISFAEDEAGELYFMSTEIPSATSPTGVVYKIVDPSRRAPPGKCHYEPHSVRVKSNIIPFEPKETLIGVHIPTKQPKLSNTEEPPLVTTKDWLRELLDNFREEDGQITTTPFTPTTPKPVRTSRQRKGRRRKGKHKNGAVRLVGDEEGQRDRGRVEVYANGEWGTVCDDLWNTKNAVVVCRQLGFLHALKAAKHAEFGEGTGLKIILDDVQCEGTEETLLDCQHAGIGTHNCAHYEDAGVVCGNSVASLQ
Protein: Uncharacterized protein (Q8MLV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein
- GEO12034p1
- CG32712
- IP03738p
- AT10048p
- Uncharacterized protein
- Uncharacterized protein
- FI15228p1
- Uncharacterized protein
- Uncharacterized protein, isoform A
Sequence:
MRILWIAAISFSWQFSDAFYYMPKFLCIPPFVAINGSCLIPTPKEPTILPCLKNLQNSTVFPENREIVTVSPPNLITEDGATIGESHSKDEKPNLSIKVPVKEAGAVEGDKTNEDLNPTVPNANKVPTDSSENTLDSEPNDNFVGKPEDSNQNESNPDIITPSQHANSSIISTNQGQETNESNIPEKGSNTDSKLKPTISEDSQVNNIPPKEGAFQGDNTNKDLNPTVPDESNVPTESSENTSDSEFDDNNIGKPEDSDQNESNPDIVTPSQHENSSLISTNHGQETNESNLPENGSNKGSKLKLPTPENSQINQTPPEAGAVNQDLNPTVPDANKLPTESSENALDSEFNGNNVGKPEDSHQNESNPDIITPSKHENSSLISTNPGQETNGIRDPVNGSNAISTLKPPVSENSQINQIPSEAGEVEGDKANKDLNLDDPNVNKLSSENTINSGPNNTNISKPEDCDPNESNSNIIAPNKPANSSITSTNPGQEANGIRYPVNGSIASSILNPNVSKPTKLDGKNFESNLAVGNENKTENITEDPNQNPKKENTIVSSISENPTMNKTGGLLTENMEGLSSTSSAKIPSTRPTISQPPKKGIAILPVKRPSRIYSTDDLNPPKFEIPSISGADAGVLPISPSIPDTDKINSGILPSGIPIQTPLPVDLNPSKDPSMPEMLPVRDPSIPDTENLIKNTLPPEGPSKIVLPGDLHTPIIPDTNEVINGLLPSERPNQIPLSGNTSHPNTHSITGIGSATKPVVPALPGTDNLTPKIIDPKIHIPESKEPILPKIPETDHLINEEDLIGKQQSPKIHIPGAPKINDPKIHIPESKEPILPKIPETDHLINEDLIRKPQSPKIHIPETPKIIEPKIQIPKDPKMPKLIRPEDLYPKDINIYELLPKDMFA
Protein: Putative head protein (H9C194)
Organism: Pectobacterium phage ZF40 (Bacteriophage ZF40)
Interaction partners:
Sequence:
MRITIRDRVAFPVPSQREITPEGYLKVPGRVARVGIQQYLASELGLTDRPPGQLVNVYRPPEEVFKPSSLASYDNMDVTIDHPDDLVDSTTFKEVTAGHAISSGRQDGDYVVVDLLIKDQQAIDEIDAGKAELSAGYTSEYDETPGTAPDGTPYEFIQRDIKINHIALCDQARAGRKARLFDAKPTGENPMPFKVVLDSGVHATVAEEATAQLIQASFDSLKKRVKDAEEEKEKAEAAKDQTEEELEKEKAKSDAKDEEIEKLKEKTSEDSISKLIAEVVSVRDSAAKIAGEKFSCDSLDPMKIRRAALDSMGIKCKHGSWDKASDAYVLAYFDAEEERKENEDDEEDGENKSSNDSLNAFTRDMKQVKTGDAQATRDGVRQSWLDKRYGTQEAK
Protein: 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) (O43741)
Organism: Homo sapiens (Human)
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Interaction partners:
- 5'-AMP-activated protein kinase subunit gamma-1
- 5'-AMP-activated protein kinase subunit gamma-3
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- 5'-AMP-activated protein kinase subunit gamma-2
- 5'-AMP-activated protein kinase subunit beta-1
- Glycogen [starch] synthase, muscle
- Serine/threonine-protein kinase STK11
- Calcium/calmodulin-dependent protein kinase kinase 2
- Cystic fibrosis transmembrane conductance regulator
Sequence:
MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
Protein: SH3 and cysteine rich domain (Q8WUK8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004278}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFHEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI
Protein: ATP-dependent DNA helicase II subunit 1 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku70) (Q6FQX8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- ATP-dependent DNA helicase II subunit 2
- DNA ligase 4
- Double-strand break repair protein
- DNA repair protein RAD50
- Candida glabrata strain CBS138 chromosome E complete sequence
- DNA ligase
- Serine/threonine-protein kinase TEL1
- Candida glabrata strain CBS138 chromosome I complete sequence
- Telomerase reverse transcriptase
- DNA repair and recombination protein RAD52
Sequence:
MSELDFPDIDSNIFDEDSGKEDGEVNKQASFKRFEIHEGIMFCIELSEHMFEVQDELDGKSQIEVILTSLSELMELLIVTRPSTAIGCYFYNCEREDSKESIFEFIPLVDLNVQWMKKVNDLLEDVSNQRITFKEYLNYNIDQNKKLNIPILLEKLFSLILETFNRNIEGQKEFNSKKVFLFTDNDLPNVESQQRSIDVLKGILKDIDDNMINFTNFFISKKDKPFNPAFYSKVLRNDRDYNSLGSQAYFGPSTKPIGVNDIKERIFQRKEIRRVVFQCPLVLDEGTNFVISIKGYSIFNHEKGSVRYKLVYENQEIRKEAFSKRKFINPKTGEDVSKQTVKIIPYGEKEIEMEDKNIANALNVYGNTSASLTVIGFLNEDNSLVFYNNIDKTLFITPDENVIEGSFTAFASLFRTLKKLKKVGVVWGSTKSNSSPSLYLLWPSKDDDNNQGFYLTKVPFIDEIRKYPTLSNININEEWEEYKNVKELTQGIISHFNLKSGYHAEEFRNPALNRHYKLLHDYLLQVEIPQDDNDIRDRYLREDDTLLKITKIRERIMKDTTIDDVEKRRLSKYLEVWNIYYRKFKEDTNQTSSSLLKSEKKPKLNL