wanglab/gogpt-training-data huggingface dataset:
Protein: Protein SHORT HYPOCOTYL IN WHITE LIGHT 1 (F4I3V6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negative regulator of photomorphogenesis modulating both light and abscisic acid (ABA) signaling pathways. Regulates negatively the light-mediated inhibition of hypocotyl elongation, probably in a PHYB-mediated signaling pathway, but promotes flowering time (especially in long days) and lateral root formation. Enhances light-regulated gene expression. Promotes COP1-mediated degradation of HY5 during seedling development (e.g. hypocotyl growth) through enhanced ubiquitination in the darkness. Also involved in root gravitropism.
Subcellular location: Nucleus membrane {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:18375596, ECO:0000269|PubMed:26474641}; Multi-pass membrane protein {ECO:0000255}. Note=Constitutively localized in the nucleus of hypocotyl cells. {ECO:0000269|PubMed:18375596}.
Interaction partners:
- E3 ubiquitin-protein ligase COP1
- Thioredoxin Y2, chloroplastic
- Oleosin 21.2 kDa
- Non-specific lipid-transfer protein 12
- Glutamate dehydrogenase 2
Sequence:
MAAATTTLSSSSSSPSLTLINASHRFVSVTPFSSNSIFLRRRFRRLNRSLASSSSHSRRRYESDDRFFGGGDNYDVVPDDDGFSDDDDEEDERESSVDLLIRFLRSMFKKVSKRTKKASRRILPAAMSPRLVSFAVDGILLLGSLSITRAFLEVICNLGGTVFTVILLIRLFWAAASFFQTYGNSFGPNPVN
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF (Q6P2U7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866}.
Interaction partners:
- Ezrin
- Moesin a
- Cystic fibrosis transmembrane conductance regulator
- Ezrin a
- Moesin b
- Podocalyxin
Sequence:
MSSDLRPKLCVLEKGDTGYGFHLHGEKNKPGQFIRHVEPDSPAAAAGLLAGDKLALVNGENVEDEKHQQVVSRIRDTVGKLELVVLNAETAELLLKHNLKCQKEYVTDGIPIPAGSEPEDEVKNGTSSRESTPVPETNGDMRIDRLSVSSKDSKNELRPRLCHIKKGATGYGFNLHTEKTKPGQYIRAVDEDSPAEKSGLRPQDKIVQVNGISVHTMQHSEVVAAIKAGGDETKLLVVDPEADAFFMSCEILPTEEHLTGPLPEPIPRREAEEQVNGKVVQEEKPKVEMSLSSSSTSSNTSTSAAPAPASAPAPASAPAPASAPAPAMAAAPQEKVKEKASSADAGLALNMSLQQAKERAHQKRSNKRAPQMDWSKRNELFSNL
Protein: 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Q5ACY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Transaminase A
Sequence:
MSRRVLPALHEIAIRQGLENINQLGYPHWSFVKLDEPPAHVLTVHYQLKNFKTTWEFLNSVAELAASKRHHPTIITTYNKVDIQLTTHDSDNSVTQDDLDMAEAIQKQYHELTK
Protein: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (DOPA/tyrosine sulfotransferase) (Sulfotransferase family cytosolic 1B member 1) (P52847)
Organism: Rattus norvegicus (Rat)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8530477}.
Interaction partners:
- Carbohydrate sulfotransferase 10
- UDP-glucuronosyltransferase 2B15
- Sulfotransferase 2A2
Sequence:
MGTAEDVFRKDLKIIHGYPMVYAFALGWEKIEEFQSRPCDIVIPTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVITSKVPMLEQNVPGARRSGVELLKKTPSPRIIKTHLPIDLLPKSFWDNKCKMIYLARNGKDVAVSYYHFDLMNNIQPLPGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKREGHPILFLYYEDLKKNPKKEIKKIANFLDKTLDEHTLERIVHHTSFEVMKDNPLVNYTHLPTEIMDHSKSPFMRKGVVGDWKNYFTMTQSEKFDAIYKKKLSGTTLEFCTDIQSA
Protein: High mobility group AT-hook 2 (A0A8I6A172)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSARGEGAGQPSTSAQGQPATPAPQKRGRGRPRKQPQEPTCEPSPKRPRGRPKGSKNKSPSKAAQKKAETIGEKRPRGRPRKWVSKDNKETVCLWVWVTRV
Protein: Riboflavin transporter rft-2 (Solute carrier family 52, riboflavin transporter rft-2) (G4SDH4)
Organism: Caenorhabditis elegans
Function: Riboflavin transporter.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable FAD synthase
- G-protein coupled receptors family 1 profile domain-containing protein
- Riboflavin transporter rft-1
- Folate transporter 1
Sequence:
MGCSAATFILVALFGSSSWMGTNSVWMQLPLLTSELPEQWNLPSYLAGVVQIACIVPLIYTILHKGVKSFTIPTAPLIIALLSLACCCQLGLSFFWSDYSEIFGAPRSWPLYSLLFGLAIVNAMSNVLFMPFMAQFHPAYLNAYFVGMGLSSLAPSLLSLAQGTSMFKCDEKGVAERFPPNFSVSIFFFVIFSFTCVALFAFIALYRSGAHTHFATPNKKEPNEGTPLKKDLNNTSSSRKGDDEDESPIEIHETGAPAIDAIVSELDVTFREELQKSFRDANYLERSAMINDDSEPHPVDYITGVKFTFLLFTTALVNAQMNGIITSVQSYAALPYSQATYHFAVTLSNVVSPLSSFLPFFISVRSIPVLAILTACSTAMTAFIVYLAALSPNLIFNSVTIGSALSIGGSLIAAGLHSYLRVVFASLLREGHQSESRLFWCGVFIQIGSFIGSAVMFPLVNIAHLFTSAPQCKSIS
Protein: Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (MAGE-E1 antigen) (Q6PCZ4)
Organism: Mus musculus (Mouse)
Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:14623885}. Nucleus {ECO:0000269|PubMed:14623885}. Cell membrane {ECO:0000269|PubMed:14623885}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane.
Interaction partners:
Sequence:
MSLVSQNSRRRRGGRANARRNNGKGHPAAVPGPDVPRDRNDPKILQGLRASEGPGTSMLPTPREGPSASVPPTASEGSSAPRQFIISQGPNTSEMPTSRKGRGASRPPAVSAGLNTAMSITASEGPNSPVPPTAPKGSKAYEHLPVSEGLAISEQRHSDGGPNMEPTLGEGPGISVPPTFSEESGISDEGLSIFMSPNISEGPGINEPYSVSEDPSTSVPPTDSNGLGINLPPTFGEGLSISMLFSALEEPDIFAPPPSAEGLFASMSPPSGEIQSSWVSPIIMEGCNVNVPPTSKKGLRTSVPSAACESPSTSAEGLSSSLSSISAEGFCSSLAPCAAEGSCELLPCGEGRSTSELHCLGEGSSTSQMSLAAEGPSASGMPTEANNPEEALSCCASERRNKSTSRALQKAKDPSVRPKREDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELLQFLLLKDQTKYPIKESDMREFIDKDYRHQFPEILRRAAVHLECIFRFELKELDTEEHIYILLNKLGPVPFEGLEDVPNGPKMGLLMMILGHILLNGNQAREADIWEMLWRFGVQRERRLSVFGNVKRLLSVEFVWQRYLDYRPLTDCVPVEYEFYWGPRSRAETTKMKILKFMAKIYNKDPMDWPALYNEALEEDADRVVVNNFRVARPFRRPLFAEVAPELDASGSKYSPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECTKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEDTEEIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQNGRKHVITCRYLSQRYLDSLRVPDSDPVQYDFVWGPRARLETSKMKALRYVARIHRKEPEDWPEQYREAMEDEANRAEAGRRPLIVRNLR
Protein: RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) (Q9VWE4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369031}.
Interaction partners:
- Symplekin
- Pre-mRNA cleavage complex 2 protein Pcf11
- Cleavage stimulation factor 64 kD subunit
- Cleavage and polyadenylation specificity factor 73
- Cleavage and polyadenylation specificity factor subunit 4
- Cleavage and polyadenylation specificity factor subunit 1
- Probable cleavage and polyadenylation specificity factor subunit 2
- LD24014p
- DNA-directed RNA polymerase II subunit RPB1
- Factor interacting with poly
Sequence:
MTDPSKLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDNRPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY
Protein: IFT80/172/WDR35 TPR domain-containing protein (Q38CC3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
- Intraflagellar transport protein 57/55
- Intraflagellar transport protein 80
- Uncharacterized protein
- Intraflagellar transport protein IFT88, putative
- C2H2-type domain-containing protein
- Intraflagellar transport protein A1
- Intraflagellar transport protein component, putative
- Intraflagellar transport protein 56 homolog
- Intraflagellar transport
- Ankyrin repeat protein
Sequence:
MQVKHYKTLMACQQGIARTQAICWSPNNKRLAVADNNRVVNLYDEHGERRDKFPTKAADGKNGKAFVIEGMAFSPDSSKIAIGQSDGIVAIYRVGIEWGEKKAICSKFPQNSPVTCLCWPETSQGVELVVFGTLDGKVKVGILKANKSQALYAHEHAVVSIASSPDGNKVISGHLDGAVYQYTFESEDAGGGSGSKKLFNHGHPPYVLLWGENICAAGQNSFVTFYDRSGQKVQSFDYKAEDEGEFTVGSFNPSGHAIVLASREQLRLFDFNLRSRKWEEGAVIRVPNSCSFSAISWKYDGSRFVTGSLAGAVDMFDVCLKRYRLRGAFEFTYVSHNQVIVKRLATGTRIVLRSSLGYEVQCVNVHQDRYLVAHTSTTLLVGDLISCKLSEVPWQLSGREKFVFDNPQVCMVFAAGELCLIEYGKNEILGTCRTEERNAHRISVRVHDPSITSEGEGQQGRKFIAYLIDRQTAQIDDLSSGTAVARLSHQCRIDWLELNYRANKLLFRDKQHQLFLYDLEEQNRTTLLNYCTYVQWVPGSDVVVAQNRVELCVWYSINSPDRVAVVPIKGEVEGIERGNGKTEVIVDEGVNTVAYGLDEALIEFGTAMEDHDYIKACDLLDQIALTPETEAMWANLASLALQELKLPIAQRCYAALGDMAKVNSLNQINELAVSEARSSGGATDGYDHYAVRAELSMLNKDYKQAEQLYLENAKIEDAMAMWEELNRFDESISIAEARGWPDLANKRTRYYNWLVETGQFEKAGEQKEREGKHNDAINLYLRGGTPARAANVISANNMKPESQLLEAIAASLFKAQVFEKAGDFFEKLKMNDRAIQAYKKGHVYSRAVEFAKRAVPDRVVALEEEWGDYLVSQKHVDQAINHYIEAKKYDKAVKAAIDSRQWSKAAHILESQTVGSDNDETVKGFYKNIARHYEELHQYGEAEKFYIKANAINEAVDMYSRAGMADHMYRVAQRHLSQQQLVALFVDQAKRLETKGDYAGAERIYVKVNEPDQAIVMYKKARDYTNMIRLVQAYRPDFLSKTHLSLAAQFEKESNYKMAETHYVAGKDWGRAVNMYRDHEMWEDAVRVAKVHGGANAAKQVVLSRAMVVEAEDGVRLLMKFSFINPGIEAALEAQKFDLALQWAQLAQPAKLPYVYLKYAMYYEDQGDFRMAEEAFLKSGKPREAIDMYLHQHEFENAMRVAEGYDQTAIPSILQAQGRACFQKSNYREAESFFIRANAPEPLLKLYMENRMYTDAQRVAKEYYPDMLGEIAKRIALQSSDPQKAGAVLEEHGEYQMAVETYLGATAEQVQNPNVLANLWVRAVKVAQKHDRNMLKNVLRVATGKLKEAQRYVEAGKCLEDCEDYKGAINMYVEGKKFDLAEYLAKHISPELEDYVKRAIVQNSIEGGGMKDAKMVEEIDPEAAFKAYIANNDWENALRMAKQRPPEEMKYVAGLKMKYHANKGELGAALGVVEELPLDPGDFRFYETWLEMADRILAQLPLRPDSDLKLERFHTCFSDVVESMSRSGQKQEDVAKANAFAHIIHIYYMSARMRELSLDDYALKLMLGLPRWIPHIAPEKAFYDAGMAARNSGQDAIAFLYLNRFLDISEKIEDGAVDSSAIDNGDFDCTDFPKKYPMPKSSSVEKTSEEEVNRWVLAISIDNSLDPHLPTVTDPQGQVEMFEGSLQSPAGVTYPECAVTGYPIVGGGVVKCRNCQRPANQDDWTRYITLAKACPWCGAADSPVFGI
Protein: Paxillin homolog 1 (Q09476)
Organism: Caenorhabditis elegans
Function: Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles.
Subcellular location: [Isoform a]: Cell junction, adherens junction {ECO:0000269|PubMed:21633109}. Cell membrane {ECO:0000269|PubMed:21633109}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:21633109}. Cell projection, podosome {ECO:0000269|PubMed:21633109}. Note=Colocalizes with pat-3 to dense bodies, adhesion plaques and M lines in body wall muscles. Colocalizes with deb-1 in podosome-like structures in the pharyngeal muscle. Requires unc-95 for the localization to dense bodies. {ECO:0000269|PubMed:21633109}.; SUBCELLULAR LOCATION: [Isoform c]: Cell projection, podosome {ECO:0000269|PubMed:21633109}.
Interaction partners:
- Vinculin
- FERM domain-containing protein
- Paralyzed arrest at two-fold protein 6
- Integrin-linked protein kinase homolog pat-4
- Alpha-actinin, sarcomeric
- Arf-GAP domain-containing protein
- Actin
- Integrin beta pat-3
- Inactive tyrosine-protein kinase kin-32
- Ras-like GTP-binding protein rhoA
Sequence:
MPSDDRFADAVKPALEALLSDLQHTTEVLRRAHISDRRSQSRDDFEQSYDLQGNLNTQSVSNGNITTSPYKRRSSEGKDYSKSQERIYENESRLNPPVYSRPSVQSLLSQVEEPPIRASSSRKSLGPPSQAQSYSDVRSNGRSPSRDPLHSDSMIGTMNGELSSKHGVNTIPKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPFFERNGRAFCEEDYHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDFFRLFAPKCNGCSQPITSNFITALGTHWHPDCFVCQHCGVSFNGASFFEHNGAPLCERHYHESRGSICSQCRGAINGRCVAAMGRKFHPEHFRCSYCNHQLTKGTFKEVDRRPFCHKCYNNTYALTPA
Protein: Regulator of G-protein signaling 7 (O17589)
Organism: Caenorhabditis elegans
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-1
- Regulator of G-protein signaling rgs-11
- Regulator of G-protein signaling rgs-3
- Diacylglycerol kinase
- Abi_C domain-containing protein
- Regulator of G-protein signaling rgs-9
- Guanine nucleotide-binding protein alpha-16 subunit
Sequence:
MMPPLTKIEVLAKRVMEGAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYRLQRPYFWPSQAELVPDVEYAIYLNKRLLRNEQKHGLEEDEVESFNRLADVLAHMWAFIVQQSELQLKQQKEKKKVDKVVFDSEERAFWKIRKPSRGGPNFLEDPYMKIEKKIRRQNAQGYRCLMDRLRFAIKTKPWLKALKASDTMVTWVDQRAEFDPFLHPPQPSNPWISDEASFWNQPTDTSSAEIPTEKRVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKAKDASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKAVLTAAQQHGTKRLGWRNFVFNMGTTKKPATSKPAKPQDSIGTGQVLPKQLSSDSLPVRQAHGVKPDPE
Protein: Pcdhb22 protein (Protocadherin beta 22) (Q52KQ3)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MVAKVSAKDLDTGTNGEVSYSLFHSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGGLSGKCSVSIQVVDVNDNYPELIISSLTNPIPENSPETEVALFRIRDRDSGENGRTICSIQDGVPFTLEPSVENFYRLVTDGALDREIRAEYNITISVTDLGIPKLTTQHTITVQVSDINDNAPAFTQVSYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPQLALNSLISINADNGQLFALRALDYEALQAFEFHVSATDRGSPALSSQALVRIVVLDDNDNAPFVLYPMQNASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSASVTLQVLMVDGFSQPYLPLPEVVRDPSHQEGDVLTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGGCSVPEGHFPGHLVDVSGAGTLSQSYQYEVCLTGDSQSNEFKFLKPVFSGIVDQNYGRQPDDQSFSSVLGM
Protein: Uncharacterized protein Rv1520 (P9WLV5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv1518
- Uncharacterized protein Rv1519
- PGL/p-HBAD biosynthesis glycosyltransferase Rv2957
Sequence:
MSIVSISYNQEEYIREALDGFAAQRTEFPVEVIIADDASTDATPRIIGEYAARYPQLFRPILRQTNIGVHANFKDVLSAARGEYLALCEGDDYWTDPLKLSKQVKYLDRHPETTVCFHPVRVIYEDGAKDSEFPPLSWRRDLSVDALLARNFIQTNSVVYRRQPSYDDIPANVMPIDWYLHVRHAVGGEIAMLPETMAVYRRHAHGIWHSAYTDRRKFWETRGHGMAATLEAMLDLVHGHREREAIVGEVSAWVLREIGKTPGRQGRALLLKSIADHPRMTMLSLQHRWAQTPWRRFKRRLSTELSSLAALAYATRRRALEGRDGGYRETTSPPTGRGRNVRGSHA
Protein: Arginine and glutamate-rich protein 1 (Q9NWB6)
Organism: Homo sapiens (Human)
Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.
Subcellular location: Nucleus {ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:30698747}. Nucleus speckle {ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}. Chromosome {ECO:0000269|PubMed:21454576}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters (PubMed:21454576). Colocalizes with MED1 in nuclear speckles (PubMed:21454576, PubMed:36533631). Binding of sisRNA promotes phase separation and localization to nuclear speckles (PubMed:36533631). Associated with glucocorticoid response elements of target genes, even in the absence of glucocorticoid receptor ligands (By similarity). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:36533631}.
Interaction partners:
- Serine/arginine-rich splicing factor 11
- Arginine/serine-rich protein PNISR
- SRSF protein kinase 2
- Luc7-like protein 3
- Poly
- Nuclear cap-binding protein subunit 2
Sequence:
MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
Protein: Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) (Q9NYG2)
Organism: Homo sapiens (Human)
Function: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane. Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin. Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A. In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16647879, ECO:0000269|PubMed:19001095, ECO:0000269|PubMed:21926431, ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the Golgi cis cisterna. {ECO:0000250|UniProtKB:Q8R173}.
Interaction partners:
- Prolyl endopeptidase
- Palmitoyltransferase ZDHHC11
- Palmitoyltransferase ZDHHC5
- Golgin subfamily A member 7
Sequence:
MMLIPTHHFRNIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLIPSRDYVYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV
Protein: Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1) (P08181)
Organism: Drosophila melanogaster (Fruit fly)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:24615015}.
Interaction partners:
- Casein kinase II subunit beta
- Casein kinase II subunit beta'
- Stellate protein CG33237
- Stellate protein CG33239/CG33241
- Stellate protein CG33238
- Ste:CG33242
- Stellate protein CG33236/CG33240/CG33244/CG33245
- Stellate protein CG33246
- Stellate protein CG33247
- Stellate protein CG33243
Sequence:
MTLPSAARVYTDVNAHKPDEYWDYENYVVDWGNQDDYQLVRKLGRGKYSEVFEAINITTTEKCVVKILKPVKKKKIKREIKILENLRGGTNIITLLAVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDYEIRYYLFELLKALDYCHSMGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYAYLDKYNIDLDPRFHDILQRHSRKRWERFVHSDNQHLVSPEALDFLDKLLRYDHVDRLTAREAMAHPYFLPIVNGQMNPNNQQ
Protein: Putative protein kinase C delta type homolog (EC 2.7.11.13) (P83099)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Stress-activated protein kinase JNK
- Ras-like protein 1
- 3-phosphoinositide-dependent protein kinase 1
- Caspase-8
- Moesin/ezrin/radixin homolog 1
- Protein kinase C
- cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B
Sequence:
MMFTRAQVRKQKTSNSSSQRPRSSGGSTRHETRYKQSSTSSSGAGSGLSGASGASGARRDQYRDRDHYGKHSFELPRQHSKEEAYHRDRESSAGGVDRGERSGIGGNGGGVTGGGVYVDRRTRPRSITNRRGAIKHQKTHDINGHRFVAKFFRQPTFCAFCNLFLWGFGKQGYQCIICQTVVHKKCHDKLLGKCSGSVFTSASTILLRERFKIDMPHRFKPHTFMSPTFCDHCGSLMGGFFIQGLKCEECDVNCHKKCERLTANLCGVNQKLIVEALNHVKRGAREARDSPSTPPSLNPAYKIEASEEHDETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNPHITLD
Protein: Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S31) (CEP76) (S37) (YS24)] (P05759)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Subcellular location: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Small ribosomal subunit protein eS31]: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS17A
- Large ribosomal subunit protein eL20A
- Large ribosomal subunit protein eL31A
- Large ribosomal subunit protein eL36A
- Small ribosomal subunit protein eS17B
- Small ribosomal subunit protein eS28B
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein eS1B
- Small ribosomal subunit protein eS25A
Sequence:
MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHKKVKLAVLSYYKVDAEGKVTKLRRECSNPTCGAGVFLANHKDRLYCGKCHSVYKVNA
Protein: MFS transporter, putative (Q4WYG0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSEEAPKHEAPSVISPIENEEKGLAPKPLERVPPNGGAKAWACVAGSFLLQFCSFGYVNACGIFQLYYQETMLKDQTSSALAWITTLQIFLLFMFGPAVGKMIDVYGCRRTLPPFSIGAVFSVCMLSLCTKYWQVMLAQGVAFGLAAAGLSLPAMATATQWFSTKKGLAVGIVSAGSSLGGVIYPCMLPRLIEQVGFASAVRWTALMQGILLFIANLLCSSPYPPLGRASKEASAEKDATEPTPRRSGLRGFKSLPWGFFVLGCFFTMWGLFAPLNYLPEMAALHGYQSFARYTLAIANAGSLVGRIVPGWVSDIIGQFNTMCIVTSLSGVLVLAFWLPLEFHTSLAGIIVFALLFGFVSGGFVSLGPPCVVSLAEDRVDEIGVKLGGFCLAIALGALTGLPIEGAIKDREGNKFTGLMCFAGATMILGGVCTGTARVFKGGPRLMKKV