wanglab/gogpt-training-data huggingface dataset:
Protein: BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) (Q9NXR7)
Organism: Homo sapiens (Human)
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15465831, ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:15465831, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:24075985}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19261748}.
Interaction partners:
- Lys-63-specific deubiquitinase BRCC36
- BRISC complex subunit Abraxas 2
- BRISC and BRCA1-A complex member 1
- Breast cancer type 1 susceptibility protein
- BRCA1-A complex subunit Abraxas 1
- BRCA1-associated RING domain protein 1
- BRCA1-A complex subunit RAP80
- Serine hydroxymethyltransferase, mitochondrial
- DNA repair protein RAD51 homolog 1
- Breast cancer type 2 susceptibility protein
Sequence:
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
Protein: ARM repeat superfamily protein (F4JAY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MSSSIVSQLQALKSVLQADTEPSKRPFTRPSILFSPKEAADFDIESIYELGLKGLEVLGNKDERFKNYMNDLFSHKSKEIDRELLGKEENARIDSSISSYLRLLSGYLQFRASLETLEYLIRRYKIHIYNLEDVVLCALPYHDTHAFVRIVQLLSTGNSKWKFLDGVKNSGAPPPRSVIVQQCIRDKQVLEALCDYASRTKKYQPSKPVVSFSTAVVVGVLGSVPTVDGDIVKTILPFVDSGLQSGVKGCLDQQAGALMVVGMLANRAVLNTNLIKRLMRSIIDIGREHAKESSDPHSLRLSLMALINFVQLQSVDLIPRKALDLFNEIRDISGVLLGLSKEFNIKRFLAVLLDSLLFYSSSDDKCCEVLASIIETVPVSNLVDHLISKVFSLCMTQYQKNSDFRSSTSVVGSWAKKFLVVVSKKYPAELRAAVPKFLEATEVQSKKEDLKLEMLSCMLDGNSDMSHPFVDSKLWFRLHHPRAAVRCAALSSLNGVLKDDSSKAENLVTIQDAILRQLWDDDLAVVQAALSFDKLPNIITSSGLLDALLHVVKRCVGILVSGVSHNVQLAVDVVALSLKIAVSSFGNQTDSTEKVTSAMFPFLLIQPKTWNLNLLVLKLGKDVNWPLFKNLAADDGMKKLPDIMSTNLSSISMDIINDLGEALSLDPDERRIELIERACNYKLSEVLETCSNIKCSEQDRNKLQKGLLIRESVSALNIDVINKLVEAFMMHPADYIQWLTVSCRDSTLSKTLFYMILMHSLQKMNSSSGKLLSITEWEELEVEVDVSLKELSKSNCQELLYQLLDTSDFTALNSKVLICLFWKLGESFIKLEPAHDASVLNKRLSSGLEDLFFFFATTRLRHVFKEHLHFRVREAKVCPVLFLSRLISREDVPPLVQIESLRCFSYLCSSGNNEWLIQVFSSFPVLLVPMSSDNQDVKAAAINCIEALFNLRCRVESSKKNGSAAIYGSSFDELLGMIVQQRRLILSDNKFFASYLTSLLSSTTNDLLVPVGLQKRFDQSTKENILSVILLCAEDLPAYGKLRVLSLLKDLGIMLMRDEIVKLLSQLLDKRSQYYYKLDKTSQPLSDTEVDLLCLLLECSMMRTSSFKGQSLDDHILSALNVDCMASERPAVISPCLTILEKLSNRFYDELQTDVQIRFFHKLVSMFRSSNGSIQNGAKEAVLRLKLSSSTVVLALDRITQQDTLVIGSLSKKKKQKKNSKSCPEEDINSEEFRSGEKALSFIASLLDMLLLKKDLTHRESLIRPLFKLLQRSMSKEWVKIAFSIEETSLQPPQDVRETTPTFISSIQQTLLLILKDIFDSLNMNPLKAEVANEINVKMLVELAHSSNDGVTRNHIFSLFTAIVKFVPDKVLDHIISILTLVGESTVTQIDSHSKSIFEGFISMVIPFWLSKTKSEEQLLQIFVKVLPDIVEHRRRSIVAYLLGVIGERNGLPALLVLLFKSLISRKDSAWLGNANVSESFASIVKKEWEYSFAMEICEQYSSSTWLSSLVILLQTISKDSKQCFLQMRLVLEFVFQKLQDPEFAFAVSLEPRNNVSVGIQQELQELMKCCICLLQAIDAKKEKDVTSSVRNEIRMRIHDVLMTVTGAMDLSIYFRVVTSLLQQQTDYNGTKKVLGLISERAKDTSSSKMKHKRKISNQKGRNSWLNLDEVAVDSFGKMCEEIVHLINATDDESGVPVKRAAISTLEVLAGRFPSGHPIFRKCLAAVAECISSKNLGVSSSCLRTTGALINVLGPKALIELPCIMKNLVKQSLEVSFASQSGRNATAEEQLLMLSVLVTLEAVIDKLGGFLNPHLGDIMKIMVLHPEYVSDFDKNLKSKANAIRRLLTDKIPVRLTLQPLLRIYNEAVSSGNASLVIAFNMLEDLVVKMDRSSIVSSHGKIFDQCLVALDIRRLNPAAIQNIDDAERSVTSAMVALTKKLTESEFRPLFIRSIDWAESDVVDGSGSENKSIDRAISFYGLVDRLCESHRSIFVPYFKYVLDGIVAHLTTAEASVSTRKKKKAKIQQTSDSIQPKSWHLRALVLSCLKNCFLHDTGSLKFLDTNNFQVLLKPIVSQLVVEPPSSLKEHPHVPSVDEVDDLLVSCIGQMAVASGSDLLWKPLNHEVLMQTRSESVRSRMLSLRSVKQMLDNLKEEYLVLLAETIPFLAELLEDVELSVKSLAQDIIKQMEEMSGESLAEYL
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic-interferon-induced mortality 19 protein) (GRIM-19) (NADH-ubiquinone oxidoreductase B16.6 subunit) (Q95KV7)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:18721790}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:Q9P0J0}. Note=Localizes mainly in the mitochondrion. May be translocated into the nucleus upon IFN/RA treatment. {ECO:0000250|UniProtKB:Q9P0J0}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
Sequence:
MAASKVKQDMPPVGGYGPIDYKRNLPRRGLSGYSMFAVGIGALLFGYWSMMKWNRERRRLQIEDFEARIALMPLLQAEKDRRVLQMLRENLEEEATVMKDVPGWKVGESVFHTTRWVTPMMGELYGLRASEEVLSATYGFIWYT
Protein: Checkpoint kinase 2 (B7ZBF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGHVTQSDLELLLSSDPPASASQSAGIRECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREA
Protein: Tryptophan-specific transport protein (Tryptophan permease) (P0AAD2)
Organism: Escherichia coli (strain K12)
Function: Involved in the transport of tryptophan into the cell.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:7814318}; Multi-pass membrane protein {ECO:0000269|PubMed:7814318}.
Interaction partners:
- Trp operon repressor
- Anthranilate synthase component 1
- Aromatic amino acid transport protein AroP
- HTH-type transcriptional regulatory protein TyrR
- Bifunctional protein TrpGD
- Tryptophanase
Sequence:
MATLTTTQTSPSLLGGVVIIGGTIIGAGMFSLPVVMSGAWFFWSMAALIFTWFCMLHSGLMILEANLNYRIGSSFDTITKDLLGKGWNVVNGISIAFVLYILTYAYISASGSILHHTFAEMSLNVPARAAGFGFALLVAFVVWLSTKAVSRMTAIVLGAKVITFFLTFGSLLGHVQPATLFNVAESNASYAPYLLMTLPFCLASFGYHGNVPSLMKYYGKDPKTIVKCLVYGTLMALALYTIWLLATMGNIPRPEFIGIAEKGGNIDVLVQALSGVLNSRSLDLLLVVFSNFAVASSFLGVTLGLFDYLADLFGFDDSAVGRLKTALLTFAPPVVGGLLFPNGFLYAIGYAGLAATIWAAIVPALLARASRKRFGSPKFRVWGGKPMIALILVFGVGNALVHILSSFNLLPVYQ
Protein: Uncharacterized protein YehM (P33349)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YehP
- Uncharacterized protein YehL
- Uncharacterized protein YfdF
- Uncharacterized protein YehI
- Uncharacterized protein YfeS
Sequence:
MSEPLIVGIRHHSPACARLVKSLIESQRPRYVLIEGPADFNDRVDELFLAHQLPVAIYSYCQYQDGAAPGRGAWTPFAEFSPEWQALQAARRIQAQTYFIDLPCWAQSEEEDDSPDTQDESQALLLRATRMDNSDTLWDHLFEDESQQTALPSALAHYFAQLRGDASGDALNRQREAFMARWIGWAMQQNNGDVLVVCGGWHAPALAKMWRECPQKINKPELPSLADAVTGCYLTPYSEKRLDVLAGYLSGMPAPVWQNWCWQWGLQKAGEQLLKTILTRLRQHKLPASTADMAAAHLHAMALAQLRGHTLPLRTDWLDAIAGSLIKEALNAPLPWSYRGVIHPDTDPILLTLIDTLAGDGFGKLAPSTPQPPLPKDVTCELERTAISLPAELTLNRFTPDGLAQSQVLHRLAILEIPGIVRQQGSTLTLAGNGEERWKLTRPLSQHAALIEAACFGATLQEAARNKLEADMLDAGGIGSITTCLSQAALAGLASFSQQLLEQLTLLIAQENQFAEMGQALEVLYALWRLDEISGMQGAQILQTTLCATIDRTLWLCESNGRPDEKEFHAHLHSWQALCHILRDLHSGVNLPGVSLSAAVALLERRSQAIHAPALDRGAALGALMRLEHPNASAEAALTMLAQLSPAQSGEALHGLLALARHQLACQPAFIAGFSSHLNQLSEADFINALPDLRAAMAWLPPRERGTLAHQVLEHYQLAQLPVSALQMPLHCPPQAIAHHQQLEQQALASLQNWGVFHV
Protein: Programmed cell death protein 2 C-terminal domain-containing protein (Q38CC0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small ribosomal subunit protein uS5
Sequence:
MREVLLGVFDGYMPLERNKLTSETKIGGSPTYRPSLSESQLMTIREWTTCGVCGRHMFLVLQAFSPLPQSSAGHHRMIYVFCCNSDACSRQPSSSWCAFTLQAENMDEEALDDIQSEEAARSDPVMASELPPSTFPPCYVAIDSEPRKEIVVPTDLEAEMIRAAQENAKNPDITENDIKELEQTIDLKDKPADYEFDKFRRRVAREPSQVIRYYERFPTESCGVTLVSAVAPPLFMRPSRVKEIIRIPPCRDCGAALIHELQIMPTSVYYLRVRDYIASGSPSGDEGVDWGTVTVFVCSKDCSKDRSGSSLRKEFVFVEKAPEQQDELENLEGRVDLRTFMTGRT
Protein: Neurensin-2 (Q9GZP1)
Organism: Homo sapiens (Human)
Function: May play a role in maintenance and/or transport of vesicles.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMPSCNRSCSCSRGPSVEDGKWYGVRSYLHLFYEDCAGTALSDDPEGPPVLCPRRPWPSLCWKISLSSGTLLLLLGVAALTTGYAVPPKLEGIGEGEFLVLDQRAADYNQALGTCRLAGTALCVAAGVLLAICLFWAMIGWLSQDTKAEPLDPEADSHVEVFGDEPEQQLSPIFRNASGQSWFSPPASPFGQSSVQTIQPKRDS
Protein: Leucine-rich repeat transmembrane neuronal protein 4 (B4F7C5)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the development and maintenance of the nervous system (By similarity). Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Glypican 4
- Receptor-type tyrosine-protein phosphatase S
- Protein cornichon homolog 3
- Neurexin-3
- Glutamate receptor 1
- Neurexin-1
- Protein cornichon homolog 2
- Neurexin-2
- Glutamate receptor ionotropic, NMDA 1
- Noelin-3
Sequence:
MGFRLITQLKGMSVLLVLFPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNVSQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSDVQVVNTERSHLAPQTPQKPPFFPKPTIFKSDAIPATLEAVSPSPGFQIPGTDHEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHVKPLPYYSYDQPVIGYCQAHQPLHINKAYEAVSIEQDDSPSLELGRDHSFIATIARSAAPAIYLERITN
Protein: Viral transcription factor IE2 (IE2) (Protein UL122) (Q6SWP7)
Organism: Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
Function: Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. In addition, activates quiescent cells to reenter the cell cycle and up-regulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.
Subcellular location: Host nucleus {ECO:0000269|PubMed:9151854}. Note=Colocalizes with host PML-associated nuclear bodies.
Interaction partners:
Sequence:
MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFERVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSVSSAPLNKPTPTSVAVTNTPLPGASATPELSPRKKPRKTTRPFKVIIKPPVPPAPIMLPLIKQEDIKPEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGTPRVTSPTHPLSQMNHPPLPDPLGRPDEDSSSSSSSCSSASDSESESEEMKCSSGGGASVTSSHHGRGGFGGAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFCTPNVQTRRGRVKIDEVSRMFRNTNRSLEYKNLPFTIPSMHQVLDEAIKACKTMQVNNKGIQIIYTRNHEVKSEVDAVRCRLGTMCNLALSTPFLMEHTMPVTHPPEVAQRTADACNEGVKAAWSLKELHTHQLCPRSSDYRNMIIHAATPVDLLGALNLCLPLMQKFPKQVMVRIFSTNQGGFMLPIYETAAKAYAVGQFEQPTETPPEDLDTLSLAIEAAIQDLRNKSQ
Protein: BCL2 interacting protein 3 (A0A8I6AQ99)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRAEIDTHSFGEKNSTLSEEDYIERRREVESILKKNSDWIWDWSSRPENVPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSHLLAIGLG
Protein: RuBisCO accumulation factor 1 (Q8DI26)
Organism: Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
Function: A major RuBisCO chaperone. Acts after GroEL-GroES chaperonin to fold and/or assemble the large subunit of RuBisCO (ccbL, rbcL). Cooperates with RbcX in RbcL folding, plays the major role in assembly of dimers into RbcL(8)-Raf1(8) intermediate complexes. RbcS replaces Raf1, leading to holoenzyme formation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00856, ECO:0000269|PubMed:25041569}. Note=Interacts with the large subunit of RuBisCO in the cytoplasm. {ECO:0000269|PubMed:12240834}.
Interaction partners:
- Ribulose bisphosphate carboxylase large chain
- RuBisCO chaperone RbcX
- Tll2145 protein
- Tll2367 protein
- Tsr1335 protein
- Carboxysome assembly protein CcmM
- Tll1852 protein
- Tsr1701 protein
- Tlr0654 protein
- CP12 polypeptide
Sequence:
MSQDQDALTTEVLQRLRRKEGTWQDWGAGCRQLQKQGLSPQAIFEATGIEPIHQNQLITALQVSQSLGEAPESVRAYFQTRGSDLLYELRVLSAGDRLAAATLIVEKQLDVTAVHEVCRALKAVSYRKDNSEGFGESVGDRIGRYYWQLARQQRDLAQRSRLIAQGLRFVESASGRQALEKLLTDFTVVPAVNQPRLPLYRLDTAEEVPYLVPVAGTAPLTATVLQQVPRLSCTEVFRVVAVPQGMSLVALPAWQVLLNAVDPVAILWPAADLPAELPPSPEGLPIAQVLLVVDRGLAEWDRDRYLLIAPSPSEAVQLAWLPEPPTATVVGQLLLVLRPPQVLDESLNRELWFFEE
Protein: Anoctamin (Q8IN71)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
Sequence:
MTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKEIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASIQEPNAKFINIEKLLTENLTQIEMDAIIHGENPITGISGADCLDEVHKKLSD
Protein: F-box/kelch-repeat protein At1g64840 (Q9XIR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g48340
- DNA-binding protein
- DCD
- F-box protein At5g52880
- F-box/kelch-repeat protein At3g24760
- F-box/LRR-repeat protein At1g67190
- Putative F-box protein At1g47730
- F-box protein At4g27050
- Glycosyltransferase
- F-box protein At1g30790
Sequence:
MMPNWSQLPEELLNLISKNLDNCFDVVHARSICRSWRSAFPFPSSLSTLSYSLPTFAKFPLVSKDLCTLKKIQIFLFRARNPAADIPEYFLGGIDQDQSNDHMELPSPLQCSVKVKFPQSDPFLVNMLDYQIIPLGFQYIMIGWDPESLANGYVGVAFLPVKKNGGDEFVVLLRYRNHLLVLRSSEMRWMKVKKTSIASCKGLVSFRGRFYVTFLNGDIYVFDPYSLEQTLLMPSEPLRSSKYLIPNGSDELFLVEKFNPFPEADVLDLSRFACRVSRLDEEAGQWVEVIDLGDRVLFIGHFGNVCCSAKELPDGCGVSGNSILFTNEPGYVTFAYKYGVHTGRAEDELNIWRFSREIRVMIVNTFPVVALRLERQAENLALDT
Protein: UDP-glycosyltransferase 71K2 (EC 2.4.1.-) (UDP-glucose:chalcone 2'-O-glucosyltransferase) (UDP-glucose:flavonol 2'-O-glucosyltransferase) (D3UAG2)
Organism: Pyrus communis (Pear) (Pyrus domestica)
Function: Glycosyltransferase that possesses chalcone and flavonol 2'-O-glycosyltransferase activity. Converts phloretin to phlorizin (phloretin 2'-O-glucoside), a potent antioxidant. Possesses glycosyltransferase activity toward quercetin, isoliquiritigenin, butein and caffeic acid.
Interaction partners:
Sequence:
MKKVELVFIPSPGAGHLVPTLQFAKRLIDRNDRISITILAIQSYFPTTLSSYTKSIAASEPRIRFIDVPQPQDRPPQEMYKSPAKFFSLYIESQVPSVKKIITNLVSSSANSSDSIRVAALVVDLFCVSMIDVAKELNIPSYLFLTSNAGYLAFMLHLPIVNEKNQIAVEESDPEWSIPGIVHPVPPRVFPVALTDGRCSAYIKLASRFRETRGIIVNTFVELETHAITLFSTDDGIPPVYPVGPVIDMDDGQAHSNLDQAQRDRIIKWLDDQPQKSVVFLCFGSMGSFRAEQVKEIALGLEQSGQRFLWSLRMPSPIGTVPCDCSNLEEVLPDGFLERTNGKKGLICGWAPQVEILAHSATGGFLSHCGWNSILESLWHGVPITTWPMYAEQQLNAFRMARELGMALEMRLDYKRGSADVVGADEIERAVVGVMEKDSEVRKKVEEMGKMARKAVKDGGSSFASVGRFIEDVIGENSGFK
Protein: Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) (Q9BYE7)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}.
Interaction partners:
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- YY1-associated factor 2
- Lethal
- Transcription factor E2F6
- RING1 and YY1-binding protein
- Chromobox protein homolog 3
- Chromobox protein homolog 7
- Polycomb complex protein BMI-1
- Polyhomeotic-like protein 1
Sequence:
MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
Protein: F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B) (Q8BFZ4)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus.
Interaction partners:
- Cryptochrome-1
- S-phase kinase-associated protein 1
- Cryptochrome-2
- Cullin-1
- Coiled-coil domain containing 92B
- Period circadian protein homolog 2
Sequence:
MKRNNFSAVNKVVQSSPVVKQPKRGLCSSLRQTHALSVLLDWGTLPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSYFKSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVPKSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVSSDGILCVADHCQGLRELALNYYILSDEILLALSSETHVNLEHLRIDVVSENPGQIKFHSIKKRSWDALIKHSPRVNVVMYFFLYEEEFEAFFKEETPVTHLYFGRSVSRAILGRIGLNCPRLIELVVCANGLLPLDSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRRLTQLSIMEEVLVPDDRYTPDEVHTEVSKHLGRVWFPDVMPIW
Protein: Aurora kinase (EC 2.7.11.1) (G5EDL3)
Organism: Caenorhabditis elegans
Interaction partners:
- Incenp-like protein ICP-1
- TPX2 domain-containing protein
- Serine/threonine-protein kinase plk-1
- Transforming acid coiled-coil-containing protein 1
- RING-type domain-containing protein
- Spindle-defective protein 5
- Zygote defective protein 9
- Kinesin-like protein
- Kinetochore protein ndc-80
- Cyclin-dependent kinase 1
Sequence:
MSGKENTAPVIDDQKAEVISLTEDSRPQRVDQAREESCWSLDDFDVGRPLGKGKFGNVFISREKKTKRIIALKVLFKTQLLQLGVSHQLKREIEIQYHLRHPNILTLYGYFHDDKRVFVILDYASRGELFNVLQSQPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRDIKPENLLLDSKLNLKLADFGWSVVADHSKRHTLCGTMDYLAPEMVSNQPHDFNVDIWAIGILLFEMLVGYAPFANQTGDKLIARIKECKIYIPSVVTDGAASLINAIIKKEPQERLPLVDIMAHPWIKEMKQREDIEVPLFISTLTKSSRNNSTANQ
Protein: SD10981p (Q960A7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQTLREFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCRELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVSAAPPSKKTKKDKKKK