wanglab/gogpt-training-data huggingface dataset:
Protein: Gluconate transport inducer 1 (O14367)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Promotes the onset of gluconate uptake upon glucose starvation.
Interaction partners:
Sequence:
MTEPGNLQPTFVGFIGTTVDALLLFEACRQNYTHFVDRRPQDRERERLIRSGSVFVFDEVQSGIKRWTDGIAWSPSRVIGNFLVYRQLCKKNSVSDRKRSSKSRSDSDEEEVSAFTVSVPVDVDVASHVNISSPSAPSLSDNLFPGSSFSASSQQNPSSPGSNDIKSEFAAVKNEYVLSPTSPTTSAAFPSSFSSLPLVSSKPTGTPFVPKSPPSSSPSTTNVSNASTSSAPINPRAPQTRRESISSTSSIHYCSSSSLSYLHDTERALVGSLTDSYGFKKSGLIKKTISLMIDGRLHHLISYYTPEDVLNGKLQTPSSFNLFQQLTISKDLLEYKSFRIPPLVEAAESEKISQLSTLEKRTLPSFPYNPFFSSSTAEIDPYHFQGLTLSTSPISGVESSSLSSAISRNQSNLSSFQQQQQFSALQSISNNALNENIEQPPIKMAARHSYPNFLQTLPQYMNDVYNPSGLAFNPVNPNANNSFVNLNLIQFTSPSQALFDYGEGPYVDQKSQYLQPKQPSSNTDSIDQSSYNMSLAASKQFLTSDTQPDVNENYSFISNSIPKNLSTSWNQNMGYHVTNSNSELASQNPLYAQQAVSMESMGNAIQSSAYSAMSTPHGGHYDHYAATAKGKNPLAAENHASGGRLPKVPIPPLSNMRRGSVPIIPSSASLPMRTSGNRFCHYSSLNGNHNRISARTNPYPINNQTMLFTEPLSKERGSLS
Protein: Rac-like GTP-binding protein ARAC7 (GTPase protein ROP9) (O82480)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a negative regulator of abscisic acid (ABA) responses.
Subcellular location: Membrane {ECO:0000269|PubMed:12368496}; Lipid-anchor {ECO:0000269|PubMed:12368496}.
Interaction partners:
- KOW domain-containing protein
- Rho GDP-dissociation inhibitor 1
- Guanine nucleotide exchange factor SPIKE 1
- Kinesin-like protein KIN-14E
- Heavy metal-associated isoprenylated plant protein 37
- F20B24.22
- Dol-P-Glc:Glc
- Protein trichome birefringence-like 9
- Rop guanine nucleotide exchange factor 5
- At1g12070
Sequence:
MSASKFIKCVTVGDGAVGKTCMLICYTSNKFPTDYIPTVFDNFSANVAVDGQIVNLGLWDTAGQEDYSRLRPLSYRGADIFVLAFSLISKASYENVLKKWMPELRRFAPNVPIVLVGTKLDLRDDKGYLADHTNVITSTQGEELRKQIGAAAYIECSSKTQQNVKAVFDTAIKVVLQPPRRKEVPRRRKNHRRSGCSIASIVCGGCTAA
Protein: Mitogen activated protein kinase kinase kinase 2 (F1M9D0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 5
- Serine/threonine-protein kinase PAK 2
- Serine/threonine-protein kinase PAK 1
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase
- Mitogen activated protein kinase kinase kinase 3
- Proto-oncogene tyrosine-protein kinase Src
- Mitogen-activated protein kinase kinase kinase 1
- CCM2 scaffold protein.
- Tyrosine-protein kinase Lyn
Sequence:
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVKLEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVLNGSTQATNLEPSPSPDDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYEDSRIRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHLFVHCH
Protein: MEMO1 family protein C4H3.04c (Q10212)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Large ribosomal subunit protein eL32A
- Large ribosomal subunit protein eL32B
- U3 small nucleolar RNA-associated protein 4
Sequence:
MSQAIREATHAGSWYLDDTELLTKQLKSFIKNPTPETGKRFVISPHAGYMYSGKVASQGFQQLDFSKIQRVFVFGPSHHIFTRKCLVSRASICSTPLGDLKVDEDLCQKLVASDNSFDSMTLDVDESEHSLEMQFPLLAFHLLKQGCLGKVKIVPIMIGALTSTTMMAAAKFLSQYIKDESNSFVISSDFCHWGRRFGYTLYLNDTNQLEDAVLKYKRRGGPTSPKIYESISNLDHIGMKIIETKSSDDFSEYLKTTQNTICGRYPIELIMKSMECANFSERFKFISYAQSSHVELVTDSSVSYATATA
Protein: Uncharacterized protein C216.04c (Q9Y7K1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable peptide methionine sulfoxide reductase
- Catalase
- Homoserine O-acetyltransferase
- Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1
- K
- Uncharacterized dipeptidase C3A11.10c
- Glutathione peroxidase-like peroxiredoxin gpx1
Sequence:
MGFPLEKSEDEWKKELGPEKYRIMRQKGTEHPGAGRFTHQFPKQGVFVCAACKELLYKASTKFESHCGWPAFFDNLPGKVKRIEDNSYGMHRVEAVCANCGGHLGHIFKGEGYSNPTDERHCINSASLEFHNEATNDN
Protein: diguanylate cyclase (EC 2.7.7.65) (Q9HYQ2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- cyclic-guanylate-specific phosphodiesterase
- EAL domain-containing protein
- Cyclic di-GMP phosphodiesterase PA2567
- Probable transcriptional regulator
- cyclic-guanylate-specific phosphodiesterase
- FimX
- Cyclic di-GMP phosphodiesterase RocR
- DUF2804 domain-containing protein
- EAL domain-containing protein
- cyclic-guanylate-specific phosphodiesterase
Sequence:
MCVTQKDRLDDSRSNLYADQLNRGFRGLRFLPELERDYRRYMLEDSFALKRIALSVGMLVWLAFIGIDLLILAGPPLWGVLAVRLGVLVLLLVCGCLIMLRRHIQLMVPLSIACVLALGVGAAAVVGLAHRADPGYPYEGLLLVSFAAYFLAGLRLSQALSCALVVLLAYLGFEWWAGTQEPLGNNLLFLLFGNLIGAVGCYLLEFKSREHFLISRLLRVMADHDSLTGLHNRRSFNQHLDRLWRQAQREQKTLALLLCDVDHFKAYNDRYGHQAGDAVLQRIGAVFEANARRPLDMAVRLGGEEFALLLYGANEHEARLRAEALRAQVQALRMEHEASDTAREVTLSVGVSCLWPTPGNDLKRLYDLYEHADRALYEAKAFGRNQVVA
Protein: Vomeronasal type-1 receptor (W4VSP8)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}.
Interaction partners:
- Vomeronasal 2, receptor 95
- Vomeronasal 2, receptor 31
- Vomeronasal 2, receptor 30
- Vomeronasal 2, receptor 29
Sequence:
MSSFKNVLYFQAGLGVLANMVLLLFYIFIILGHRPKPTDLISCQLTFVHIIMVLTGGDILLTDLFELLNIENDLKCKTIFYISRVMRGLSICTTCLLSVFQAVTISPNTSLMAKFKQKLKKYMACVFLCIWSFNLAFSTNRIFYVGGFTNVSETNQMQVTKSCSLLPMNIIIRGFIFTISTSRDVFLVGVMLTTSVYMVITMFRYHRQCKYLYSISHLRESPEKRATQTIVLLVSFFVVMYWVDFIISFTSDMIWMYDPLILTVQKFMMYAYPTITPLVQISSDNRIIIMLKNLQSKHQQRFFNKDIFFSL
Protein: TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) (Q9BXI6)
Organism: Homo sapiens (Human)
Function: Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.
Subcellular location: Cell projection, microvillus {ECO:0000269|PubMed:16923811}. Note=Localizes to the microvilli-rich region of the syncytiotrophoblast. In melanocytes, located at the periphery of cells.
Interaction partners:
- Ras-related protein Rab-35
- Na
- Synaptotagmin-like protein 1
- Ras-related protein Rab-27A
- ADP-ribosylation factor 6
- Cell division cycle protein 16 homolog
- Na
- Ras-related protein Rab-22A
- Ezrin
Sequence:
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
Protein: Protein DJ-1alpha (A1Z9J4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor. Does not play a role in methylglyoxal detoxification (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16203113}. Nucleus {ECO:0000269|PubMed:16203113}. Mitochondrion {ECO:0000269|PubMed:16203113}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Serine/threonine-protein kinase Pink1, mitochondrial
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MLSVLRKSFPNGVTHAHRVIRCKSNQDKCAKNALIILAPGAEEMEFTISADVLRRGKILVTVAGLHDCEPVKCSRSVVIVPDTSLEEAVTRGDYDVVVLPGGLAGNKALMNSSAVGDVLRCQESKGGLIAAICAAPTALAKHGIGKGKSITSHPDMKPQLKELYCYIDDKTVVQDGNIITSRGPGTTFDFALKITEQLVGAEVAKEVAKAMLWTYKP
Protein: L-type lectin-domain containing receptor kinase VIII.1 (LecRK-VIII.1) (EC 2.7.11.1) (Q9LFH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754}; Single-pass type I membrane protein {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754}.
Interaction partners:
- At3g52790
- Jacalin-related lectin 19
- At5g62150
- Jacalin-related lectin 3
- At4g25433
- Putative inactive G-type lectin S-receptor-like serine/threonine-protein kinase SRK
Sequence:
MSLFLSFFISILLCFFNGATTTQFDFSTLAISNLKLLGDARLSNGIVGLTRDLSVPNSGAGKVLYSNPIRFRQPGTHFPTSFSSFFSFSITNVNPSSIGGGLAFVISPDANSIGIAGGSLGLTGPNGSGSKFVAVEFDTLMDVDFKDINSNHVGFDVNGVVSSVSGDLGTVNIDLKSGNTINSWIEYDGLTRVFNVSVSYSNLKPKVPILSFPLDLDRYVNDFMFVGFSGSTQGSTEIHSIEWWSFSSSFGSSLGSGSGSPPPRANLMNPKANSVKSPPPLASQPSSSAIPISSNTQLKTSSSSSCHSRFCKENPGTIAGVVTAGAFFLALFAGALFWVYSKKFKRVERSDSFASEIIKAPKEFSYKELKAGTKNFNESRIIGHGAFGVVYRGILPETGDIVAVKRCSHSSQDKKNEFLSELSIIGSLRHRNLVRLQGWCHEKGEILLVYDLMPNGSLDKALFESRFTLPWDHRKKILLGVASALAYLHRECENQVIHRDVKSSNIMLDESFNAKLGDFGLARQIEHDKSPEATVAAGTMGYLAPEYLLTGRASEKTDVFSYGAVVLEVVSGRRPIEKDLNVQRHNVGVNPNLVEWVWGLYKEGKVSAAADSRLEGKFDEGEMWRVLVVGLACSHPDPAFRPTMRSVVQMLIGEADVPVVPKSRPTMSFSTSHLLLSLQDTLSDCNTVALNSSRSSSWSVPEHNVIIRSDDDHLV
Protein: 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (EC 2.7.1.105) (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) (Q9H178)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
IYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQPLLGQACLNWKGVMRNAA
Protein: Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform) (P37397)
Organism: Rattus norvegicus (Rat)
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Interaction partners:
- WD repeat-containing protein 90
Sequence:
MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGMGIGTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMSAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDEYPREYQYGDDQGIDY
Protein: DnaJ (Hsp40) homolog, subfamily B, member 12, isoform CRA_c (DnaJ heat shock protein family (Hsp40) member B12) (J3KPS0)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MSSLRARLPATRRRVAQPFARPASPSLVPRSGSAMESNKDEAERCISIALKAIQSNQPDRALRFLEKAQRLYPTPRVRALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTGSSLKTVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDTDMYHRAQKMGTPSCSRLSEVQASLHG
Protein: Laccase-1 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 1) (Diphenol oxidase 1) (Ligninolytic phenoloxidase) (Urishiol oxidase 1) (Q70KY3)
Organism: Melanocarpus albomyces
Function: Lignin degradation and detoxification of lignin-derived products.
Interaction partners:
Sequence:
MKTFTSALALVVGMLAPGAVVAAPPSTPAQRDLVELREARQEGGKDLRPREPTCNTPSNRACWSDGFDINTDYEVSTPDTGVTQSYVFNLTEVDNWMGPDGVVKEKVMLINGNIMGPNIVANWGDTVEVTVINNLVTNGTSIHWHGIHQKDTNLHDGANGVTECPIPPKGGQRTYRWRARQYGTSWYHSHFSAQYGNGVVGTIQINGPASLPYDIDLGVFPITDYYYRAADDLVHFTQNNAPPFSDNVLINGTAVNPNTGEGQYANVTLTPGKRHRLRILNTSTENHFQVSLVNHTMTVIAADMVPVNAMTVDSLFLAVGQRYDVVIDASRAPDNYWFNVTFGGQAACGGSLNPHPAAIFHYAGAPGGLPTDEGTPPVDHQCLDTLDVRPVVPRSVPVNSFVKRPDNTLPVALDLTGTPLFVWKVNGSDINVDWGKPIIDYILTGNTSYPVSDNIVQVDAVDQWTYWLIENDPEGPFSLPHPMHLHGHDFLVLGRSPDVPAASQQRFVFDPAVDLARLNGDNPPRRDTTMLPAGGWLLLAFRTDNPGAWLFHCHIAWHVSGGLSVDFLERPADLRQRISQEDEDDFNRVCDEWRAYWPTNPYPKIDSGLKRRRWVEESEWLVR
Protein: Photosystem II reaction center protein Y (P73676)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00717, ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:34937700}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00717, ECO:0000269|PubMed:34937700}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II reaction center protein M
- Cytochrome b559 subunit alpha
- Photosystem II extrinsic protein V
- Photosystem II reaction center protein X
- Photosystem II reaction center protein J
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein K
- Photosystem II reaction center protein L
- Photosystem II reaction center protein I
Sequence:
MDWRVIVVVSPLLIAATWAAINIGAAAIRQLQDVLGREA
Protein: PUP1 protein homolog (P40508)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:16823961}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein MRG3-like
- Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
- Uncharacterized mitochondrial outer membrane protein YPR098C
Sequence:
MLGKEEEQQYGQNGKGMENELPFMKRPWFKKAYENAIEFHEKDELLDARDRLELSKAYRSIAKAEMWGGWLGFSAVFLTPFAYRYYKTKAIKGVKVPRNFVLGVMALFFATNFAGRSMYTRQLNERDPTGVLKDNYSNKYGDNDFGAFQHDQTKEIPRNQRQYNMMRLLDSGSPSRWSMYFYITYQNPERRLPDPKVKLQQMKKGGVFNGSPFMNQRDPIGLYRNKGRKSPDPIEGEQNDSPVLSSWEKIRNGDNSSSSSWENIRNTSRDQSQESDASVDHESDIFISGFSDDGNATDNSSSDDKYQRLLQSGRYGGNRS
Protein: Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcM2) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) (P52483)
Organism: Mus musculus (Mouse)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 E1
- Ubiquitin-conjugating enzyme E2 E2
- Glutaryl-CoA dehydrogenase, mitochondrial
- E3 ubiquitin-protein ligase TRIP12
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-conjugating enzyme E2 variant 1
- Importin-11
- Ubiquitin-conjugating enzyme E2 variant 2
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-like modifier-activating enzyme 1 Y
Sequence:
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT
Protein: White collar 2 (Q5EGQ1)
Organism: Cryptococcus neoformans var. neoformans
Interaction partners:
Sequence:
MSLLAESLAGAKYMVATNDDRESSTNGAAEFLRRKRWPEILLKELVGSAVFCLKPTLILGSRQYQNGEAWSWKIIYSSPSVYEMLGQRPADLEGRDFFDLVLVDDRPQLQSFFNSLLAPPLLNVEPTLLSSEGPDTLGGSRTTYIRMLSAAPGPSRSDSSSRSSSGQRSLPQSNYGTPVGRILGPVVWEIRAHATGIGEDLGEAAGNGETLRMAADGTVVSAIREGDGKHKAIWLMARQVGEGMNEDQKSLEAFLEVKLENERLLAELQELEEEVGMTVEDSINNNQSASTPSSHSSTDTPPGGDKNKNKAGRPPKTNTQVSASGHKRQKSGTGGPAGASEGETMHVCVTCGRTDSPEWRKGPLGPKTLCNACGLRWAKRNSTHIPKKDKQS
Protein: Transmembrane protein (Q388F7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRAHTHTHTHTHRMSTEPHNEHAPHVLGRKLKARKVERLQSLRLRRRPVVSGALPAATEFCDAAGVSEVTGNKSAAQVDTSTSVCKERERSFPSTGDGCGAPRAYLNSTTSKLTKQAHFSSPYMDTRIPIACSEEYHWAPLHTSFAHELVAEHNTLVEWYEEHFIKCQQQSTERQPPFSPEENYTEVLPVWLAVARSRHRELSRFVQYHRTYFNGIDMEELQLTEECLRRLEQCLVSAGCQELTSCSDCSATLSADCYGEAAGHSPEKHPGCTALGIPRQCTNVSVEVVDDVGKGSQLSLHSFPVADSHAVQLCLGETNWRTAARVSGKDCRVVCNRPPPPVPGDLGCEGMTDDVITERDVYLQPFLTYFSFSPQGRQSRRVKLFLAIVALSLIFFCVAVALVSQKFR
Protein: SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) (Q8VD37)
Organism: Mus musculus (Mouse)
Function: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
Subcellular location: Membrane, clathrin-coated pit {ECO:0000305|PubMed:17626015}; Peripheral membrane protein {ECO:0000305|PubMed:17626015}; Cytoplasmic side {ECO:0000305|PubMed:17626015}.
Interaction partners:
- Epidermal growth factor receptor substrate 15
- Epidermal growth factor receptor substrate 15-like 1
- Synaptojanin-1
- AP-2 complex subunit mu
- AP-2 complex subunit beta
- Disabled homolog 2
- AP-2 complex subunit alpha-1
- Adaptin ear-binding coat-associated protein 1
- Adaptin ear-binding coat-associated protein 2
- AP-2 complex subunit alpha-2
Sequence:
MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGMQPSPHEPPYHSKAECAREGGKKASKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDVLKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELTSKKPLDDTLALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPMNPSTESPELARPFPTGTPPPLPPKTVPATPPRTGSPLTVATGNDQAATEAKIEKLPSISDLDSIFGPVLSPKSVAVNTEEKWVHFSDASPEHVTPELTPREQVVTPPAASDIPADSPAPAPPGPTGSAGPPGPPGPRHVPSPLNLEEVQKKVAEQTFIKDDYLETLSSPKECGLGQRATPPPPPPPTYRTVVSSPGPGSGSGTGTTSGASSPARPATPLVPCSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVVNSSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPASTDLRIDYKYNTDAMSTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
Protein: Probable protein transport protein Sec61 subunit gamma (Q09827)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Necessary for protein translocation in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein transport protein sec61 subunit beta
- Protein transport protein sec61 subunit alpha
- Uncharacterized protein C19G7.17
- Phosphatidylinositol 4-phosphate 5-kinase its3
- ER protein translocation subcomplex subunit sec67
- Translocation protein sec62
- Translocation protein sec66
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1
- Uncharacterized protein C553.06
Sequence:
MADNADDLFQIPKNFYKEGSHFIKRCVKPDRKEFLSISKAVATGFVLMGLIGYIIKLIHIPINKVLVGGA
Protein: Translation initiation factor IF-2, putative (Q57TS5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S14
- Ribosomal protein
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S15, putative
- 40S ribosomal protein S5, putative
- 60S ribosomal protein L5, putative
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- 50S ribosomal protein L2, putative
- 60S ribosomal protein L2, putative
- 60S ribosomal protein L17, putative
Sequence:
MRHTRFFQKRPCNAFYSLPSVMDVTSFVGFVRSCTNRLANFCEEDFLARNSSARCKSFDCNTRGKVREDLAPLLNLREKEVERAVWEEYGLRNERLATCIVPYQIATNIILKRLPDYVRRESAMELKREELRISRDATGFGSNRFIQWVEKDVYVSTGIDYLKRLHPRTFTRVPVIAVMGHTQHGKTTFLDTLQETNLRGEESRGSTQCLRAFTVPYIEGRRPTVTLLDTPGERTFTETRLHAQNVADFIALVVSVVDGVGSQTYETIKVALNVDNPVVVVLNKMDLFSNARKAAEAVSKTLIDLRGAGLNVTLVRSHRDLERLRADQSATEVLTDACDGAANLLQLFAPMKTIDHTYRGSRKNPCVDLSRSCVGVCVSAKGDRNIDLFWSVVELMTSAFPPKCMSRAADYTSHCCSIQGVVLESSKHLFDEEGFRTKKGVQDIVKRKDMTSRKQQSRFERNSVSVRINSSVNAVRNKMNSNNPTSSNCLVLTVVVREGCITKGMPFIVDQSKGYVDYMVDAYGNFVDRALPGTAVTLVDAHSTSGCPGAGTHVLSIPSVGERDRIFGYRRLLQWFVECFPSKLHLLRPRGMDVSFPHLGDYGQLKDTTSLEYQLLYGHAPKTHSPQLEVSENAKEHLPSVSHLGVRSIAEYMLEKNAEGESDKGRLPSQTASHVGVMSVGSKLHVERMWSQLQLESQPQSQEAYDEFVNSCIQVGVVFKVDSWHSARMLHREASKLGTRRIVFQVVGMRFGELLVDDVLFFGRAMKIVVCYRTPIGASAELDQYIEANDTWVLQTDDVSDIVSFLKWCAVALHKEHAADEFGSLGGASGSSYMLLSKDTSKGGRNTINGEGRRRRQLLLTPST
Protein: Ras GTPase-activating protein 2 (GAP1m) (Q63713)
Organism: Rattus norvegicus (Rat)
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.
Subcellular location: Cell membrane {ECO:0000305}.
Interaction partners:
- GTPase NRas
- Ras-related protein M-Ras
- Ras-related protein R-Ras
- RAS related 2
- GTPase HRas
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MAAAAPAAAALTEAPAVPGTAEPETGDEDSREVRVLQSLRGRIYEAKNLLPYLGPNKMRDCFCTINLDQEEVYRTQVVEKSLSPYFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCSHSGKETWFSLQPIDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEVFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNENLVQDVFLGEIKVPVNVLRNDSSHQAWYLLQPRDNGNKSSKPDDLGSLLLTLCYTEDYVLPSEYYGPLKALLLKSPDVQPVSASAAYILGEICRDQKDAVLPLVRLLLHHNKLVPFITAVADLDLKDTQDANAIFRGNSLATQCLTEMMKIVGGHYLKVTLKPVLDEICESSKSCEIDPVKLKEGDNVESNKENLYYYVDKVFSAIVGSSVSCPTVMCDIFYSLRQMAAKRFPNNPHVQYSAVSSFVFLRFFAVAILSPHAFHLRPHYPDTQTVRTLTLISKTIQIIGNWGCQSRRKSRFKKSVMCEFLKMFQEERYFTDVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSKELTYHKQQGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKTLYIQANNCVEANEWIDMLCRVSRCNHNRLSSFHPSAYLNGNWLCCQETSEGTPGCKPCTAGIPADIQIDIDEDRETERIYSVFTLSLLKLQKMEEACGSIAVYQGPQKEPGYSKFTIEDSVATFKTIQQIKSTIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKIS
Protein: Periplasmic protein CpxP (ORF_o167) (Periplasmic accessory protein CpxP) (P0AE85)
Organism: Escherichia coli (strain K12)
Function: Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein-mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity.
Subcellular location: Periplasm {ECO:0000269|PubMed:25207645, ECO:0000269|PubMed:9473036}.
Interaction partners:
- Sensor histidine kinase CpxA
- Transcriptional regulatory protein CpxR
- Lipoprotein NlpE
- Periplasmic serine endoprotease DegP
Sequence:
MRIVTAAVMASTLAVSSLSHAAEVGSGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSELETMHRLVTAENFDENAVRAQAEKMANEQIARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSSSNSRSQ
Protein: Core histone macro-H2A (B1WC28)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037942}. Chromosome {ECO:0000256|PIRNR:PIRNR037942}.
Interaction partners:
- Cytokine-like nuclear factor N-PAC
- Histone deacetylase 11
- Histone deacetylase 8
- Histone deacetylase
- Deubiquitinase MYSM1
- Histone deacetylase 2
- Histone deacetylase 1
- Histone deacetylase 1
- Histone deacetylase
- Protein deacetylase HDAC6
Sequence:
MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKAASGKKGGKKSKATKPRTSKKSKAKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEEIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSSSSLKNVYFLLFDSESIGIYVQEMAKLDTK