wanglab/gogpt-training-data huggingface dataset:
Protein: 23S rRNA (guanine(748)-N(1))-methyltransferase (EC 2.1.1.188) (23S rRNA m1G748 methyltransferase) (Tylosin-resistance methyltransferase RlmA(II)) (Q9S1M6)
Organism: Streptomyces fradiae (Streptomyces roseoflavus)
Function: Specifically methylates the guanosine in position 748 of 23S rRNA. Confers resistance to the macrolide antibiotic tylosine.
Interaction partners:
Sequence:
MRKNVVRYLRCPHCAAPLRSSDRTLRCENGHTFDVARQGYVNLLRRPTKLAADTTDMVAARAALLDSGHYAPLTERLAGTARRAAGAGAPDCVVDIGGGTGHHLARVLEEFEDAEGLLLDMSKPAVRRAARAHPRASSAVADVWDTLPLRDGAAAMALNVFAPRNPPEIRRILRPGGTLLVVTPQQDHLAELVDALGLLRVRDHKEGRLAEQLAPHFEAVGQERLRTTLRLDHDALGRVVAMGPSSWHQDPDELARRIAELPGIHEVTLSVTFTVCRPLP
Protein: Homeobox protein Hox-B7 (Homeobox protein Hox-2.3) (Homeobox protein MH-22B) (Homeobox protein MuB1) (P09024)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-B6
- X-ray repair cross-complementing protein 6
- X-ray repair cross-complementing protein 5
- DNA-dependent protein kinase catalytic subunit
- Homeobox protein Hox-B5
- Homeobox protein Hox-C6
- Homeobox protein Hox-B8
- Homeobox protein Hox-A7
- Pre-B-cell leukemia transcription factor 2
- Homeobox protein Hox-D4
Sequence:
MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQGLYSGGGAMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEAEEEEEE
Protein: Methyl-CpG-binding domain-containing protein 7 (AtMBD7) (MBD07) (Methyl-CpG-binding protein MBD7) (Q9FJF4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression. Requires high mCG density for binding. Recognizes preferentially mCGs located in transposable elements. Required for active DNA demethylation. Prefers to target genomic loci around chromocenters.
Subcellular location: Nucleus {ECO:0000269|PubMed:14605234, ECO:0000269|PubMed:15805479, ECO:0000269|PubMed:17208509, ECO:0000269|PubMed:17711414, ECO:0000269|PubMed:18211904, ECO:0000269|PubMed:25593350}. Chromosome {ECO:0000269|PubMed:14605234, ECO:0000269|PubMed:17208509, ECO:0000269|PubMed:18211904, ECO:0000269|PubMed:25593350}. Note=Associated with heterochromatin, at all chromocenters. Excluded from nucleolus. {ECO:0000269|PubMed:14605234, ECO:0000269|PubMed:17208509, ECO:0000269|PubMed:17711414, ECO:0000269|PubMed:18211904, ECO:0000269|PubMed:25593350}.
Interaction partners:
- Increased DNA methylation 2
- Increased DNA methylation 3
- Increased DNA methylation 1
- Methyl-CpG-binding domain-containing protein 5
- Methyl-CpG-binding domain-containing protein 2
- Methyl-CpG-binding domain-containing protein 8
- Methyl-CpG-binding domain-containing protein 1
- Alpha-crystallin domain-containing protein 22.3
- Methyl-CpG-binding domain-containing protein 13
- Methyl-CpG-binding domain-containing protein 11
Sequence:
MQTRSSSSPSANHRRETQLQIADPTSFCGKIMPGWTVVNRPRSSNNGVVDTYFIEPGTGRQFSSLEAIHRHLAGEVNDRRLTRAGSFFQDKTRVYEGSRTKQDHCGVEYASKGFRLPRGWSVEEVPRKNSHYIDKYYVERKTGKRFRSLVSVERYLRESRNSIEQQLRVLQNRRGHSKDFRLPDGWIVEEKPRRSSSHIDRSYIEPGTGNKFRSMAAVERYLISVGNITLDSVSMVHSERLPLLMNRNGIRFQSEVIDPNPPKKVKWVLTGSGGNMFTANVRGSNVSSLVKHTWSEAFVSLIEDRS
Protein: Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) (P07395)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Phenylalanine--tRNA ligase alpha subunit
- Leucine--tRNA ligase
- Isoleucine--tRNA ligase
- Threonine--tRNA ligase
- DNA-directed RNA polymerase subunit beta
- Small ribosomal subunit protein uS2
- Phosphoribosylformylglycinamidine synthase
- Methionine--tRNA ligase
- GMP synthase
- Large ribosomal subunit protein uL15
Sequence:
MKFSELWLREWVNPAIDSDALANQITMAGLEVDGVEPVAGSFHGVVVGEVVECAQHPNADKLRVTKVNVGGDRLLDIVCGAPNCRQGLRVAVATIGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHSGIIELPADAPIGTDIREYLKLDDNTIEISVTPNRADCLGIIGVARDVAVLNQLPLVQPEIVPVGATIDDTLPITVEAPEACPRYLGRVVKGINVKAPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHNKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQHKAMERATRLLIDICGGEAGPVIDITNEATLPKRATITLRRSKLDRLIGHHIADEQVTDILRRLGCEVTEGKDEWQAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEPVQASLIMGTHREADLSLKRVKTLLNDKGYQEVITYSFVDPKVQQMIHPGVEALLLPSPISVEMSAMRLSLWTGLLATVVYNQNRQQNRVRIFESGLRFVPDTQAPLGIRQDLMLAGVICGNRYEEHWNLAKETVDFYDLKGDLESVLDLTGKLNEVEFRAEANPALHPGQSAAIYLKGERIGFVGVVHPELERKLDLNGRTLVFELEWNKLADRVVPQAREISRFPANRRDIAVVVAENVPAADILSECKKVGVNQVVGVNLFDVYRGKGVAEGYKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLRD
Protein: Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) (P23771)
Organism: Homo sapiens (Human)
Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Subcellular location: Nucleus.
Interaction partners:
- Hepatocyte nuclear factor 3-alpha
- T-box transcription factor TBX21
- T-cell acute lymphocytic leukemia protein 1
- Runt-related transcription factor 1
- Estrogen receptor
- Signal transducer and activator of transcription 6
- Histone acetyltransferase p300
- LIM domain-binding protein 1
- Ubiquitin carboxyl-terminal hydrolase 21
- Interleukin-4
Sequence:
MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMG
Protein: Cellular tumor antigen p53 (Q8JHZ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}.
Interaction partners:
Sequence:
MLYLETNAPSSYSEPQYTSLGLLNSMDQNGGSTSTSPYNNDHAQNNVTAPSPYAQPSSTFEALSPSPAIPSNTDYAGPHTFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVLTNPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNDGQIAPPSHLIRVEGNSHAQYVEDSITGRQSVLVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQHVTDGTKSSEGTKRPFRQASSHLSQLNSIKKRRSTDEEVFCLPIKGREIYEILVKIKESLELMQFLPQQTIESYRQQQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPSGMPGGLTDMTPPMMGGPVPMNTDLSSLSPNNPLQSQLQMVPSSHCTPPQPRLKPLKRNLDKKSSQSV
Protein: Increased DNA methylation 1 (Histone H3 acetyltransferase IDM1) (EC 2.3.1.-) (Protein ROS4) (Repressor of silencing 4) (F4IXE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyzes H3K18 and H3K23 acetylation. Prevents the transcriptional silencing of transgenes and of some endogenous genes. Requires the presence of IDM2 for efficient H3K18 acetylation, but not for H3K23 acetylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:22700931, ECO:0000269|PubMed:22733760, ECO:0000269|PubMed:24920332, ECO:0000269|PubMed:25002145}. Note=Colocalizes with IDM2 within nucleoplasmic and nucleolar foci. {ECO:0000269|PubMed:24920332, ECO:0000269|PubMed:25002145}.
Interaction partners:
- Increased DNA methylation 2
- Increased DNA methylation 3
- Methyl-CpG-binding domain-containing protein 7
- DNA glycosylase/AP lyase ROS1
- Protein REPRESSOR OF SILENCING 3
- Protein IDA-LIKE 1
- Methyl-CpG-binding domain-containing protein 6
- DEMETER-like protein 2
- Berberine bridge enzyme-like 5
- DEMETER-like protein 3
Sequence:
MLPGAEIEMLGGDCFEGSYEDHQIFREVFFGSDPGNTTKRCLVTGAINFECDSSKNVNSSLSSNSVVTSGYACPQGFEASASRDGSDFNTKAKRVKLSGNKHLDARDEKGSALHGFPTSDIARETIPLHLVESSNKGVSTSSYLLKHSIVKGREVYLGGIVSGKCKSLNLDKCDGKEFKAIASPVSQESFATRMISVGASTPHSEKACFPLQLNNGSKVSPNELIMSKTCLKIDPKEDPRPLLYKYVCKVLTAARWKIEKRERSAGRKHVDTFYISPEGRKFREFGSAWKALGGILLADRKLMDTGTKKWTGINDFWSDLSLTLLDIEENMKNLNLANTRALWWSALEPFVVVVFISKQVGSLRKGNKVEVARNSNPDKLKKEDTICLNLISGCPESVLTVSEGSHLVHDVDANQEIHSDLEVQTKISSQKVSSRLERQSIIGKEISGTHEQEASKGIVASKLIAEDMHESVMRKNLHRRSKKISDIKPASLDQHDSLDSNSLNSFEFQDKEMGNIHLVSKGSRDERLRNEKMNNSCCNSKKGRKKARKHYTQDDDLMGSTITRNKGKFSRSSQKKKTQKPKARTKKRNNRGGCRLLPRSSSNVENHFFQGNWSILGPRTVLSWLIATKVISRDEVIQLRDPDDDTVVKTGLVTKDGVVCTCCNKTVSLSEFKNHAGFNQNCPCLNLFMGSGKPFASCQLEAWSAEYKARRNGWRLEKASDDDPNDDSCGVCGDGGELICCDNCPSTFHQACLSMQVLPEGSWYCSSCTCWICSELVSDNAERSQDFKCSQCAHKYHGTCLQGISKRRKLFPETYFCGKNCEKVYNGLSSRVGIINPNADGLSWSILKCFQEDGMVHSARRLALKAECNSKLAVALSIMEESFLSMVDPRTGIDMIPHVLYNWGSTFARLDFDGFYTVVVEKDDVMISVASIRVHGVTIAEMPLVATCSKYRRQGMCRILVAAIEEMLMSLKVEKLVVAALPSLVETWTEGFGFKPMDDEERDALKRINLMVFPGTTLLKKTLYESTKPSTMKGVCLSKERNNPSNKEADLEPGLDKAGSPMSTQVESCDQMVPAGSDDEPSPGFPVPLGADQTEPTSETENPSRDSNANDRPNKTTVVSIGEEEEEECLQKDVSKLSEEGKETTRASSSSAALEEVSGLGLGVVNNVSDEMLLCVDEQLDSDSSQDSE
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Somatomedin) (P16545)
Organism: Sus scrofa (Pig)
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05017}.
Interaction partners:
- Tyrosine-protein kinase receptor
- Insulin-like growth factor-binding protein 1
- Tyrosine-protein kinase receptor
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor-binding protein 5
- Insulin
- Pro-epidermal growth factor
- Hepatocyte growth factor
- IGFBP N-terminal domain-containing protein.
- Decorin
Sequence:
MGKISSLPTQLFKCCFCDFLKVKMHITSSSHLFYLALCLLSFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKEVHLKNTSRGSSGNKNYRM
Protein: Cytoskeleton assembly control protein Sla2 (Q2U538)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Clathrin light chain
- Clathrin heavy chain
- ENTH domain-containing protein
- ENTH domain-containing protein
- non-specific serine/threonine protein kinase
- Actin associated protein Wsp1
- WH2 domain-containing protein
- Actin binding protein
- ENTH domain-containing protein
- GED domain-containing protein
Sequence:
MNCRHAFNFSTLSVLIIHHPFFCNSIDFSIALHCRSAQVLPVRAQSNCAVWTRAHRLPPHIVVCSPDPTPRQFTGLQPVTMSRTEADLAINIRKATSIEESAPKRKHVRSCIVYTWDHKSSAAFWAGMKVQPVLADEVQTFKALITIHKVLQEGHPIVVREAQQHANWIDSLMRGVGGDGIRGGIGYGPLIREYVFFLESKLAFHRNHPEFNGLFEYEEYISLKTINDPNEGYETISDLMTLQDQIDAFQKLIFSHFQSGTNNECRISALVPLVQESYGIYKFITSMLRAMHTSRSYLPSCCLATGDAEALEPLRGRYDAQHYRLVRFYYECSNLRYLTSLITIPKLPQNPPNLLSDDDERPALPRRPTKEIEQEPTPPPKAPPADPEPINDFWTTEAKRQQEEFEAEQRRLQQQWEEQQRQQILAQQQAQHDFEEQQRLQAEQQRLAQEQLLRDQYQTQTQGRLAELEQENLNARAQYERDQLMLQQYDRRVKDLEEQMNQLTSNLNMQSASKDEQIRSLQEQVNTWRSKYEALAKLYSQLRQEHLDLLQTTKSLKLKAASAQEAIERREKLERELKTKNLELADMIRERDRALHDRDRLTGNNKEELEKVKRELRLAIERAENAERQKGTEISTLLSKYNREMADLEEALRNKNRALEDISSRNADRQGDHDAVLREKDEEIEVYKSGMEQALMELEELKMNQGDVDNALDSQIDTVLHSTVAKINDIIDSVLQTGVQRVDDALYELDSSMQAGNQNASPPYVLSQIEKASASATEFSTAFNNFIADGPNSTHAEIIRTVSIFSGSVADVLSNTKGLTRFANDDKSADQLINAARKSAQATVRFFRGLQSFRLEGLEADHKTDVVINNNLEVQRDLQSLSKLVETFAPKSTKISTNGDLGDLVDQELTKAADAIDAAAARLAKLKKKPRDGFSTYELRINDVIVEAAIAVTNAIAELIKAATESQQEIVREGRGSSSRTAFYKKNNRWTEGLISAAKAVATSTNTLIETADGVISGRNSPEQLIVASNDVAASTAQLVAASRVKASFMSKTQDRLEAASKAVGAACRALVRQVQEIIAERNQDGSEKVDYAKLSSHEFKVREMEQQVEILQLENSLAQARQRLGEMRKISYQED
Protein: Late embryogenesis abundant domain-containing protein / LEA domain-containing protein (Putative seed maturation protein) (Q9SIN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alpha/beta-Hydrolases superfamily protein
- Late embryogenesis abundant protein 29
- Late embryogenesis abundant protein
- Late embryogenesis abundant domain-containing protein / LEA domain-containing protein
- AT1G27990 protein
- Late embryogenesis abundant protein 6
- Oleosin
- At5g19070
- Defensin-like protein 205
- Late embryogenesis abundant protein 7
Sequence:
MASEQARRENKVTEREVQVEKDRVPKMTSHFESMAEKGKDSDTHRHQTEGGGTQFVSLSDKGSNMPVSDEGEGETKMKRTQMPHSVGKFVTSSDSGTGKKKDEKEEHEKASLEDIHGYRANAQQKSMDSIKAAEERYNKAKESLSHSGQEARGGRGEEMVGKGRDSGVRVSHVGAVGGGGGGEEKESGVHGFHGEKARHAELLAAGGEEMREREGKESAGGVGGRSVKDTVAEKGQQAKESVGEGAQKAGSATSEKAQRASEYATEKGKEAGNMTAEQAARAKDYALQKAVEAKETAAEKAQRASEYMKETGSTAAEQAARAKDYTLQKAVEAKDVAAEKAQRASEYMTETGKQAGNVAAQKGQEAASMTAKAKDYTVQKAGEAAGYIKETTVEGGKGAAHYAGVAAEKAAAVGWTAAHFTTEKVVQGTKAVAGTVEGAVGYAGHKAVEVGSKAVDLTKEKAAVAADTVVGYTARKKEEAQHRDQEMHQGGEEEKQPGFVSGARRDFGEEYGEERGSEKDVYGYGAKGIPGEGRGDVGEAEYGRGSEKDVFGYGPKGTVEEARRDVGEEYGGGRGSERYVEEEGVGAGGVLGAIGETIAEIAQTTKNIVIGDAPVRTHEHGTTDPDYMRREHGQR
Protein: Candida glabrata strain CBS138 chromosome E complete sequence (Q6FV55)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MQLNHLLLSALISVASAANTTVPDVPSSCSFTTTTATAQSDLDKLAGCENIVGDVVISGSLGNAALANVKAIYGSFKVNNATSLNNLAADSLQKVTGTLALQSLTILTSASFGSLEEVDTINLITLPAISTFSSNLKSANNILISDTSLESIDGFSDLEEVAVFNINNNRYLTSLKSSVKTVSDSLQFSFNGDQSSLTFDDLLWANNITLRDVDEVSFKKLESVNSSLGFINNSISSLSVDNLKSVGQSFSIVSNDDLTSVSFANLSTIGGALVVANNTNLKDLSTFKNVQTIGGALIVTGNFTTLDMSSLKSVRGGADIETKAGNFSCDPFKKLQSKGGIQGDNFVCKNGATSTSISLTSRSSSASQSSSSQRASATASGNSSNSASTAASTSSANKQKSKGAAAGLADSFQGSSLMGALAAVALALI
Protein: Carboxylesterase 1F (EC 3.1.1.1) (Carboxylic ester hydrolase) (Triacylglycerol hydrolase 2) (TGH-2) (Q91WU0)
Organism: Mus musculus (Mouse)
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (By similarity). Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis.
Subcellular location: Lipid droplet {ECO:0000305|PubMed:16804080}. Cytoplasm, cytosol {ECO:0000269|PubMed:16804080}. Endoplasmic reticulum {ECO:0000269|PubMed:16804080}. Microsome {ECO:0000250|UniProtKB:Q64573}.
Interaction partners:
- Cytochrome P450 2E1
- Myeloperoxidase
- Beta-glucuronidase
- Arylamine N-acetyltransferase 2
- Arylamine N-acetyltransferase 1
- Cytidine deaminase
- Arylamine N-acetyltransferase 3
- Phosphoenolpyruvate carboxykinase, cytosolic
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1A1
Sequence:
MFLSTLFLVSLATCVICGNPSSPPVVDTAHGKVLGKHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGDTKNSDQFVTSVLDGVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFASMTGIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSPQRPKNVVGDHADDVYSVFGAPILREGASEEEINLSKMVMKFWANFARNGNPNGKGLPHWPKYDQKEGYLHIGGTTQQAQRLKEEEVTFWTQSLAKKQPQPYHNEL
Protein: Conserved ATPase (P96281)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Phosphatidylserine decarboxylase proenzyme
- Uncharacterized HIT-like protein Rv0759c
- Molybdopterin molybdenumtransferase 2
- Mycobactin import ATP-binding/permease protein IrtB
- Thioredoxin-like reductase Rv2466c
- Proteasome subunit beta
- Mycobactin import ATP-binding/permease protein IrtA
- Proteasome subunit alpha
- Glycerol kinase
Sequence:
MTHPDPARQLTLTARLNTSAVDSRRGVVRLHPNAIAALGIREWDAVSLTGSRTTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGARSVTLSGSTLATQSVPPVTLRQALLGKVMTVGDAVSLLPRDLGPGTSTSAASRALAAAVGISWTSELLTVTGVDPDGPVSVQPNSLVTWGAGVPAAMGTSTAGQVSISSPEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRLVTLDGPEIGALAAGDRVKAVASAVQAVRHEGGVLLITDADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTGDLNLDEIASRTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSRSASDEVTVGDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAANVTAADLATARETVRASLDPLQVASLRKFGTKGDLRS
Protein: Crumbs homolog 3 (Drosophila) (Q4V8I0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATPGLGLLLAFGLPMLPSGWSQETPDSFTNSTTQPPDGGGSNGGLSSEAIVAITVVFSILGTLLIAVGLFLLMRKLREKRQTEGTYRPSSEEQVGARAPPPPNLKLPPEERLI
Protein: Large ribosomal subunit protein uL13m (54S ribosomal protein L23, mitochondrial) (YmL23) (Q12487)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL33m
Sequence:
MSQKIGHSGLAFARLWHHVDVARDKRTLGRLASAIAITLIGRHKPVYHPSQDCGDYVVVTNCQKIRVTGKKFEQKTYWSHSGRPGQLKLQTMNKVVADKGFGEILKKAVSGMLPKNKLRKQRLDRLKVFDGSENPYKQNITAFAHEQSSIPEPLKESIFNQLK
Protein: Mitochondrial glycine transporter (Appoptosin) (Solute carrier family 25 member 38) (Q91XD8)
Organism: Mus musculus (Mouse)
Function: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23115192}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03064}.
Interaction partners:
- Glutaredoxin-related protein 5, mitochondrial
- Protoporphyrinogen oxidase
- Uroporphyrinogen-III synthase
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- ATP-binding cassette sub-family B member 6
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Uroporphyrinogen decarboxylase
Sequence:
MGVSAEPRSLSVAGAGLASPVIEKARSALLQSQDVEDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQALQPSDLGPRRVGMLAVFLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSSKQYFLRGHPPTALESVILGMGSRSVAGVCMSPITVIKTRYESGTYSYESIYAALRSIYCSEGHRGLFRGLTATLLRDAPFSGLYLMFYSQTRTAVLHGTAQLDAALIPLINFSCGIFAGVLASLVTQPADVIKTHMQLSPVKFQWIGQAATLIFKNHGLRGFFHGSVPRALRRTLMAAMAWTVYEEMMARMGLKS
Protein: Cytochrome P450 84A4 (EC 1.14.-.-) (F4JW83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cytochrome P450 involved in the production of catechol-substituted substrates needed for the arabidopyrones biosynthesis. Converts p-coumaraldehyde into caffealdehyde.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- 4-coumarate--CoA ligase 1
- Flavone 3'-O-methyltransferase 1
- 4-coumarate--CoA ligase 2
- F5F19.5 protein
- 4-coumarate--CoA ligase 4
- Aldehyde dehydrogenase family 2 member C4
- 4-coumarate--CoA ligase 3
- 4-coumarate--CoA ligase-like 7
Sequence:
MLTLMTLIVLVPLLLFLFPHLLLRRQMLLKPYPPGPKGLPVIGNILMMNQFNHRGLAKLSRIYGGLLHLRLGFSHIFVVSSPDIARQVLQVQDHVFSNRPTTIAIRYLTYGGSDLAFCNYGPFWRRMRKLYVMMLFSRKRAESWVSVDEEVHKSVRLVASNVGKPLNICKLAFSLSRDITFRAAFGSSSSTSDESRLDEFLEIIQEFSKLFGEFNVADYVPSWLSWIDPQGINGRVEKARKSLDGFIESVIDDHLHKKKREHDNVDEETDMVDQLLAFYEEEVKVNNSVTKINLDNIKGIIMDVMFGGTETVALAIEWVLTEILRSPENMKRVQDELTSVVGLDRWRVEDTHLEKLTFLKCILKETLRLHPPFPLLLHETVKDTEISGYFIPKGSRVMVNTYALGRDPNSWSDPESFNPGRFLNPIAPDLKGNNFEFVPFGSGRRSCPGMQLGLYAFELAVAHLLHCFTWSLPDGMNPGDVDTVEGPGLTVPKAIPLVAVPTTRLLCPIVVS
Protein: Beta-1,3-N-acetylglucosaminyltransferase radical fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) (Q6KFX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Regulates neurogenesis in the hindbrain; involved in boundary cell specification via Notch-mediated activation of wnt1 expression.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Notch receptor 3.
- Neurogenic locus notch homolog protein 2 precursor
- Notch receptor 1b.
- Beta-1,3-N-acetylglucosaminyltransferase manic fringe
- Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
- Rac family small GTPase 3b
Sequence:
MHLSHVASNKTCFLLSLAFCALLVLLIPSLQPPQRQADLPQPRPHAKPAKHPLKNSLYRPNEDTRGGGFTQTPPPDNLEKMDDLNSHYRDFLDLRDIFIAVKTTRKYHKSRLQLLSQTWVSRAKEQTFIFTDGEDKELRLKAGLNIINTNCSAAHTRQALCCKMSVEYDKFIESQKKWFCHVDDDNYVILPSLLELLSSYSHTQDVYLGRPSLDHPIEAAERVKSDGSVSVKFWFATGGAGFCISRGLALKMSPWASLGNFITTAEKIRLPDDCTIGYIIEALLEVPLTHTGLFHSHLENLQRLPAENILRQVTLSYGGFENRRNVVSVGGAFSLAEDPTRFKTVHCKLYPDTEWCPRKTRH