wanglab/gogpt-training-data huggingface dataset:
Protein: 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) (Elastase 2',3'-cyclic-nucleotide 3'-phosphodiesterase) (P06623)
Organism: Bos taurus (Bovine)
Function: Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates. May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P16330}; Lipid-anchor {ECO:0000250|UniProtKB:P16330}. Melanosome {ECO:0000250|UniProtKB:P09543}. Note=Firmly bound to membrane structures of brain white matter. {ECO:0000250|UniProtKB:P16330}.
Interaction partners:
- Myelin basic protein
- Myelin-associated glycoprotein
- Glial fibrillary acidic protein
- Oligodendrocyte transcription factor 2
- Myelin proteolipid protein
- Myelin-oligodendrocyte glycoprotein
- Galactocerebrosidase
- NADH dehydrogenase 1 beta subcomplex subunit 7
- Platelet-derived growth factor receptor alpha
- Nestin
Sequence:
MSSSGAKDKPELQFPFLQDEETVATLQECKTLFILRGLPGSGKSTLARFIVDKYRDGTKMVSADSYKITPGARGSFSEEYKQLDEDLAACCRRDFRVLVLDDTNHERERLEQLFELADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSAALWKTGQTFLEELGNHKAFKKELRHFVSGDEPREKIELVTYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQDVVKKSYCKAFTLTISALFVTPKTTGARVELSEQQLALWPNDVDKLSPSDNLPRGSRAHITLGCAGDVEAVQTGIDLLEIVRQEKGGSRGEEVGELSRGKLYSLGSGRWMLSLAKKMEVRAIFTGYYGKGKAVPIRSGRKGGSFQSCTII
Protein: Calcium-dependent protein kinase 5 (EC 2.7.11.1) (PbCDPK5) (A0A509AQE6)
Organism: Plasmodium berghei (strain Anka)
Function: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). Plays a central role in host erythrocytes and hepatocytes infection cycles. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK4. Involved in merosome egress from host hepatocytes, probably together with CDPK4. Required for the release of hepatic merozoites from merosomes in the host blood stream. During the asexual blood stage, required for merozoite egress from host erythrocytes by triggering microneme secretion (By similarity). Phosphorylates transporter NPT1 at late schizont stage (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0A5K1K8H0}. Cytoplasmic vesicle, secretory vesicle, microneme membrane {ECO:0000250|UniProtKB:A0A5K1K8H0}; Peripheral membrane protein {ECO:0000250|UniProtKB:A0A5K1K8H0}; Cytoplasmic side {ECO:0000250|UniProtKB:A0A5K1K8H0}. Cell membrane {ECO:0000250|UniProtKB:A0A5K1K8H0}; Peripheral membrane protein {ECO:0000250|UniProtKB:A0A5K1K8H0}; Cytoplasmic side {ECO:0000250|UniProtKB:A0A5K1K8H0}. Note=During the late stages of schizogony, localizes to the cytoplasm in immature daughter merozoites, co-localizes with AMA1 to a subset of micronemes and to the apical region in maturing daughter merozoites, and near the plasma membrane in mature daughter and free merozoites. {ECO:0000250|UniProtKB:A0A5K1K8H0}.
Interaction partners:
Sequence:
MCEHKANNKNDGEFVNLKEKNENNHCGNTKSTIADCDDDYSIITLCTKCLSTKTEVNKNKIILDSKALKDSRTKRRSSVNINIDILNNNLNLSPYFDRSQIVQETILMNNDDLEKLYELDKYKLGKGSYGNVVKAINKKTGQAKAIKIIDKKRINNIERLKREILIMKQMDHPNIIKLYEVYEDNEKLYLVLELCTGGELFDKIVKHGSFSEYETYKIMKQIFSALAYCHSKNIIHRDLKPENILYVDSSDDSPIQIIDWGFASKCMNNHNLKSVVGTPYYIAPEILKGKYDKKCDIWSSGVIMYILLCGYPPFNGKNNDDILKKVKKGEFVFDSNYWSKISLDAKELICECLNYNYKERIDVHKIVNHKWFIKFKNYNHITINKHLSKELIEKFKKFHKLCKIKKLAITCIAYQLNKKKFGKMKKTFEAFDHNGDGVLTISEIFQCLKVGDNEIDRDLYYLLKQLDTDGNGLIDYTEFLAACLDHSILEQDAVCRNAFKIFDANGDGIITKDELLNVLSFSNDQMPFSKEIIENVIKEVDANNDGYIDYDEFYKMMSGRQS
Protein: MYND-type domain-containing protein (Q20741)
Organism: Caenorhabditis elegans
Interaction partners:
- Cell surface receptor daf-1
Sequence:
MSEEAEAGPSPKVNGENGNGTNTFDDLYVDDKMRRMIVDLQRQWLTDYHDSREKSLVALTEKLHQEFMEDQERVRRDLLVQFKIELDQTKEELEKKHAENLKEEIEKLSEKHQRELAVAKKKQWCWQCNSEAIYHCCWNTAYCSVECQQGHWQIHRKFCRRKKSNGGAPGPVQPIAEPTQSQQ
Protein: CX chemokine ligand 34b, duplicate 11 (F1Q6N2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- C-C motif chemokine
- Chemokine
- C-C motif chemokine 19a.2 precursor
- C-C motif chemokine
- Chemokine
- C-C motif chemokine 25
Sequence:
MHLSSVSHQMVISSHLLLLLYAFTSVVFISVSEGWSSTDKNFDNRPGVCFKVLTTKEPKANIKRCYNLPKTNNCLKCVLFVDASNRMKCIDPNASWLAERLYRLKEKGVTCRGEA
Protein: ERCC1-like central domain-containing protein (Q93456)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA repair endonuclease XPF
- Crossover junction endonuclease MUS81
- XPA C-terminal domain-containing protein
- Structure-specific endonuclease subunit SLX1 homolog
- DNA mismatch repair proteins mutS family domain-containing protein
- SAP domain-containing protein
- DNA mismatch repair protein
- XPC
- Exonuclease 1
- DNA ligase IV
Sequence:
MKHTEESLMSTTEKSRKAEEDDEKDMKKRTQFPSSSTSSDPPVGIGGSGALVVNRRRQEGNPVLKYVRNVRYEWGDIGPDFECGPTFGVVYLSFKYHKQHPEYVYTRINGNAENRYRNKVLLGYCNMEEPRHVLRELNMICFREAWTFVVVYTVEEAAEYIELFKTTQKKEITIKKKAIDDGGDSSMSDERRRNREAAIGFLTAARSITKTDADRLLFHFGTLQAISTASETSISACPGVGPIKAKNLHSFLHAIISPNEQD
Protein: V-type proton ATPase 21 kDa proteolipid subunit c'' (V-ATPase 21 kDa proteolipid subunit c'') (Vacuolar proton pump 21 kDa proteolipid subunit c'') (Q2TA24)
Organism: Bos taurus (Bovine)
Function: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32764564}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase subunit S1
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit F
- V-type proton ATPase subunit D
- V-type proton ATPase subunit H
- V-type proton ATPase subunit d 1
- Renin receptor
- V-type proton ATPase catalytic subunit A
Sequence:
MTGLVLLYSGVFVAFWACLLVVGICYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD
Protein: Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) (Q8TCW9)
Organism: Homo sapiens (Human)
Function: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prokineticin-1
- Prokineticin-2
- Adenylate cyclase type 3
- Melanocortin-2 receptor accessory protein 2
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
Protein: Lethal(2) giant larvae protein (P08111)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:12545176, ECO:0000269|PubMed:18948416, ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:26481050}. Note=In larval and embryonic neuroblasts, detected in the cortex with apical enrichment from late interphase to metaphase, and uniform cortical localization during anaphase and telophase (PubMed:12545176). Localizes to the posterior cell cortex of the developing oocyte in a process dependent on the type-1 phosphatidylinositol 4-phosphate 5-kinase sktl (PubMed:18948416). {ECO:0000269|PubMed:12545176, ECO:0000269|PubMed:18948416}.
Interaction partners:
- Atypical protein kinase C
- LD29223p
- Disks large 1 tumor suppressor protein
- Bazooka, isoform B
- Protein numb
- Ras-like protein 1
Sequence:
MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSYATWSIDNPEPPSNVNYVPYGPDPCKSINRLYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPNQANETISSSIGDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQTNKASTTVNMSEIPNINISNLEDLESKRNTTETSTSSVVIKSIITNISHEKTNGDNKIGTPKTAPEESQF
Protein: Large ribosomal subunit protein eL6x (60S ribosomal protein L6-3) (Q9C9C5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein eL32z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL6z/uL6y
- Large ribosomal subunit protein eL13x
- Small ribosomal subunit protein eS6y
Sequence:
MPAKQRTPKVNRNPDLIRGVGKYSRSQMYHKRGLWAIKAKNGGVFPRHDAKSKVDAPVEKPPKFYPAEDVKKPLPNRRTAKPTKLRASITPGTVLIILAGRFKGKRVVFLKQLASGLLLVTGPFKINGVPLRRVNQAYVIGTSTKVDISGVTLDKFDDKYFGKVAEKKKKKTEGEFFEAEKEEKKEIPQVKKDDQKAVDAALIKAIEAVPELKTYLGARFSLKQGMKPHELVF
Protein: Serine protease 2 (EC 3.4.21.-) (Protein Jonah 99Ciii) (C0HKF8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Major function may be to aid in digestion.
Interaction partners:
Sequence:
MKLFVFLALAVAAATAVPAPAQKLTPTPIKDIQGRITNGYPAYEGKVPYIVGLLFSGNGNWWCGGSIIGNTWVLTAAHCTNGASGVTINYGASIRTQPQYTHWVGSGDIIQHHHYNSGNLHNDISLIRTPHVDFWSLVNKVELPSYNDRYQDYAGWWAVASGWGGTYDGSPLPDWLQSVDVQIISQSDCSRTWSLHDNMICINTDGGKSTCGGDSGGPLVTHDGNRLVGVTSFGSAAGCQSGAPAVFSRVTGYLDWIRDNTGISY
Protein: Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) (Q8NDH3)
Organism: Homo sapiens (Human)
Function: Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Interaction partners:
- Syntaxin-16
Sequence:
MANVGLQFQASAGDSDPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPCRVSRHNSPSAAHFITRLVRTCLPPGAHRCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVTVEFFLVGQDNGPVEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGFGGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAAIKQGFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDMATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLGCEVDVEEGDLGRDSKRRRLV
Protein: BK channel (H8ESD6)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGEIYSPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPSETDPFLKQQEEKHLGWMTEDSLAMQLYRSIRDRRAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSQTTPDWLNLYLCGAGMEMYTDTLSHSFVGMTFPEAVDLLFNRLGLLLLAIELKDEENKECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRNTKHSTAARDYSDFDALFYQNDARATDVLQQFQPQAPAGPMGHLGQQVQLRMINQQRPSSGGRRNSMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASLNIKAMQFDDTLGFFPMRHQTGDRSPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDNPDSMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEPGKRHF
Protein: Regulator of chromosome condensation (RCC1) family protein (Regulator of chromosome condensation-like protein) (Q9M2S1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 3-oxo-5-alpha-steroid 4-dehydrogenase family protein
- DNA repair RAD52-like protein 1, mitochondrial
Sequence:
MNGEGKLETGGTSAAATPKEEKEEEEVVSQRVVYMWGYLPGASPQRSPLMSPVEVKIPPAVESSWKDVSGGGCGFAMATAESGKLITWGSTDDLGQSYVTSGKHGETPEPFPLPPEVCVQKAEAGWAHCVAVTENQQVYTWGWRECIPTGRVFGQVDGDSCERNISFSTEQVSSSSQGKKSSGGTSSQVEGRGGGEPTKKRRISPSKQAAENSSQSDNIDLSALPCLVSLAPGVRIVSVAAGGRHTLALSDIGQVWGWGYGGEGQLGLGSRVRLVSSPHPIPCIEPSSYGKATSSGVNMSSVVQCGRVLGSYVKKIACGGRHSAVITDTGALLTFGWGLYGQCGQGSTDDELSPTCVSSLLGIRIEEVAAGLWHTTCASSDGDVYAFGGNQFGQLGTGCDQAETLPKLLEAPNLENVNVKTISCGARHTAVITDEGRVFCWGWNKYGQLGIGDVIDRNAPAEVRIKDCFPKNIACGWWHTLLLGQPTL
Protein: SIN3 transcription regulator family member A (H3BT34)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQV
Protein: Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (mCPEB) (mCPEB-1) (P70166)
Organism: Mus musculus (Mouse)
Function: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity). Required for cell cycle progression, specifically for prophase entry (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Membrane {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Strongly enriched in postsynaptic density (PSD) fractions. Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin. Membrane-associated. Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs. In P-bodies and stress granules (By similarity). Recruited to stress granules (SGs) upon arsenite treatment (By similarity). {ECO:0000250}.
Interaction partners:
- Poly
- Symplekin
- Fragile X messenger ribonucleoprotein 1
- Aurora kinase A
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- G2/mitotic-specific cyclin-B2
- Poly
- Polyadenylate-binding protein 1
- RNA-binding protein FXR2
Sequence:
MAFSLEEAAGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSLDFSKVCTTPINRGIHDQLPDFQDSEETVTSRMLFPTSAQESPRGLPDANGLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTQSVLSMLQNPLGNVLGKAPLSFLSLDPLGSDLDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGNGPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGASVWPSWDLLGAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKN
Protein: IP19005p (IP19111p) (Q7KT36)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein
- Chorion protein S19
- Chorion protein S16
- RE05851p
- Femcoat
- IP19013p
- Uncharacterized protein
- Chorion protein S36
- GEO10373p1
- Chorion protein S38
Sequence:
MRVRLTLLTICIYLCAAAAEDLDSIHEIRSEVEELIKGTEELNHGLQKVKDVQKGIEEKFKHQRDEIELIAGLEVAIAKLESNVQSSFQATASGVGNLTAIVNAIQGQNENSIRNLTKVELEIRKALEQVAANQNKYEQNLNEVASSVNSHLSEIQQLLSQAVIGELIGLDNKAKVLQEQQRNIVGQVGYLGELKALADRANRKVNQLEWGLVILNRTQSESLNSIEHTVHGVQVATSQVDHKLAALLNNQKNIERTLDGCKHKNPSHQKPHEIWTHPEHAPIYKPKPEGNQGYENVYASQEEAEYLYKLWYGKGQ
Protein: Putative G3BP-like protein (O94260)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable scaffold protein that may be involved in mRNA transport.
Interaction partners:
- Probable ubiquitin carboxyl-terminal hydrolase 3
- UBA domain-containing protein 6
- Putative ubiquitin thioesterase otu1
Sequence:
MTAENATLLEPVLGKDEIGWMFVQEYYTYLNKEPNRLHCFYTKKSTLIHGDEGESISLCHGQQEIHNKILDLDFQNCKVLISNVDSLASSNGGIVIQVLGEMSNKGKLSRKFAQTFFLAEQPNGYFVLNDIFRFLREDVEEEEESPDAVEKEKKDVASEPYVNGVQSQEHLPSAKEEGHYQDPAATENNFATAALISNETDSLNQATLAVPEEPVIQVTEASVPSFVSQQENQLQDEALTSNSKNADAIGASDANVATAPKSWADLIARNHPDVKSQASVSSTASTTGQTVKGVNADQTQQPTAPYTQSNELLETSVFVKNIPPETSDVSLKSAMSIFGPVKAIEFARRKGTAYVDFVNHECVQLALNKKTLQINNATLNIEERRRLFSGKFNKSGDKKSNDNYNGMKRNFRKGNRGAFDGRSKEVTTSKKQNN
Protein: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) (P32861)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a central role as a glucosyl donor in cellular metabolic pathways.
Interaction partners:
- Phosphoglucomutase 2
- Galactose-1-phosphate uridylyltransferase
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Phosphoglucomutase 1
- Glycogen [starch] synthase isoform 2
- Glycogen phosphorylase
- Glycogen [starch] synthase isoform 1
- Bifunctional protein GAL10
- Glycogen debranching enzyme
- Alpha,alpha-trehalose-phosphate synthase 56 kDa subunit
Sequence:
MSTKKHTKTHSTYAFESNTNSVAASQMRNALNKLADSSKLDDAARAKFENELDSFFTLFRRYLVEKSSRTTLEWDKIKSPNPDEVVKYEIISQQPENVSNLSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNTFLDLSVRQIEYLNRQYDSDVPLLLMNSFNTDKDTEHLIKKYSANRIRIRSFNQSRFPRVYKDSLLPVPTEYDSPLDAWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDNLGATVDLKILNHMIETGAEYIMELTDKTRADVKGGTLISYDGQVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNLWINLKAVKRLIESSNLEMEIIPNQKTITRDGHEINVLQLETACGAAIRHFDGAHGVVVPRSRFLPVKTCSDLLLVKSDLFRLEHGSLKLDPSRFGPNPLIKLGSHFKKVSGFNARIPHIPKIVELDHLTITGNVFLGKDVTLRGTVIIVCSDGHKIDIPNGSILENVVVTGNLQILEH
Protein: Endoribonuclease YBEY, chloroplastic (EC 3.1.-.-) (Q8L5Z4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endoribonuclease required for chloroplast ribosomal RNA (rRNA) processing and essential for normal growth and development. May be involved in maturation of both the 5' and 3' ends of 16S, 23S, and 4.5S rRNAs. Cleaves chloroplast rRNAs, mRNAs and tRNAs in vitro.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:21365755}.
Interaction partners:
- Oligoribonuclease
- Large ribosomal subunit protein uL24c
- Small ribosomal subunit protein mS29
- 2-succinylbenzoate--CoA ligase, chloroplastic/peroxisomal
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL43
- At3g16220
- Eukaryotic LigT
- Small ribosomal subunit protein uS17c
Sequence:
MLSRVCPTLRYNRIWSAHAREMPRATLLLLQPNFFHSSPKTALVNRLDVTSSEFSSMFRRSFHALRSTVGDWRKLPKPPGQVFAERREYRKIRRRAPKKKQELELSVSICIEEQLPDDLEIQNIAEMLRLNVPMAMTLAFNGLKDSKYKTRETDIEDLGGYETVELSVMLCNDDFICKLNKEWRGEDHATDVLSMSQHVPELKLPVLMMGDLVISVETAARQAAERGHTLLDEIRILVIHGLLHLLGFDHEISDEAEQEMEEEEELLLKNLGWKGKGLIQSAYDIQKTTTVQPEKSDDRKEGDGLRLYKPKFSYIFCDMDGTLLNSKSQISEANAKALKEALLRGLKVVIATGKSRPGAIRILKTADLTGSDGIISESSPGVFVQGLLVYGRQGKEVYRGNLDRDVCRETCLYSLEHRIPLIAFSQDRCLTLFDHPLVDSLHTIYNEPKAEIISSVDQLIAEADIQKVIFMDTTEGVSSVIRPYWSEATGDRANVVQAQSDMLEIVPPGTSKGNGVKMLLNHLGVSPDEIMAIGDGENDIEMLQLASLGVALSNGAEKTKAVADVIGVSNDQDGVADAIYRYAF
Protein: Elongation factor 1-alpha (EF-1-alpha) (EC 3.6.5.3) (Elongation factor Tu) (EF-Tu) (Q9YAV0)
Organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
Interaction partners:
- Peptide chain release factor subunit 1
- Elongation factor 1-beta
- Protein pelota homolog
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL18
- Elongation factor 2
Sequence:
MAEKPHMNLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESFKFAWILDKMKEERERGITIDLTFMKFETKKYVFTIIDAPGHRDFVKNMITGASQADAAILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQIIVAVNKMDAPDVNYDQKRYEFVVSVLKKFMKGLGYQVDKIPFIPVSAWKGDNLIERSPNMPWYNGPTLVEALDQLQPPAKPVDKPLRIPVQNVYSIPGAGTVPVGRVETGVLRVGDKVVFMPPGVVGEVRSIEMHYQQLQQAEPGDNIGFAVRGVSKSDIKRGDVAGHLDKPPTVAEEFEARIFVIWHPSAITVGYTPVIHVHTASVSSRIIEIKAKLDPKTGQVVEQNPQFLKAGDAAIVRFKPVKPLVVEKFSEIPQLGRFAMRDMNRTVGIGIVTDVKPAKVDIKAK
Protein: Chordin-like protein 1 (Kohjirin) (Neuralin-1) (Neurogenesin-1) (Ventroptin) (Q76LD0)
Organism: Rattus norvegicus (Rat)
Function: Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MEGIKYIASLVFFFVFLEASKTEPVKHSETYCMFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPTLHCLSPVHIPHLCCPRCPDSLPPMNSKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDADIFRQPANREARHSYLRSPYDPPPSRQAGGLPRFAGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKLDGKCCKVCPEEPPSQNFDSKGSFCGEETMPVYEAVLVEDGETARKVALETEKPPQVEVHVWTIRKGILQHFHIEKISKEMFGGLHHFKLVTRTTMNQWKIFAEGEAQLSQMCSSRVCRTELEDLVQVLYLERPEKDHC