wanglab/gogpt-training-data huggingface dataset:
Protein: Kappa-actitoxin-Bcs3a (Kappa-AITX-Bcs3a) (Potassium channel toxin BcsTx1) (BcsTx1) (C0HJC2)
Organism: Bunodosoma caissarum (Sea anemone)
Function: Inhibits voltage-gated potassium channels (IC(50)=405.0 nM for rKCNA1/Kv1.1, IC(50)=0.03 nM for rKCNA2/Kv1.2, IC(50)=1.31 nM for rKCNA6/Kv1.6, IC(50)=74.11 nM for hKCNA3/Kv1.3, and IC(50)=247.69 nM for insect Shaker IR). Binds the Shaker IR channels in a voltage-independent manner.
Subcellular location: Secreted {ECO:0000269|PubMed:23466933}. Nematocyst {ECO:0000269|PubMed:23466933}.
Interaction partners:
Sequence:
ACIDRFPTGTCKHVKKGGSCKNSQKYRINCAKTCGLCH
Protein: FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (E7F221)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BZ67}. Cell membrane {ECO:0000250|UniProtKB:Q9BZ67}.
Interaction partners:
- Protein ZNRD2
- Uncharacterized protein
- Integrin beta-1-binding protein 1
- Potassium channel, subfamily K, member 7
- Family with sequence similarity 89 member B.
- FERM domain-containing protein.
- Phenazine biosynthesis-like protein domain-containing.
- CDC42 effector protein
Sequence:
MEGDDGDFPPEPSEHSLSQRGSVASSVTRAQDLLVYLANDSAVHLTLEGLGCMNAQELGRSVREALNIPNSAADVFAFWFCSPLLELQLKPKHLPYKLCRQWQDLLYRFTEAPTEDISLDEPSLLFKRSVFYPRAKELQIEDEGVLRLLYDEAKMNILEGRYPCDPEHWLTLGALSCAIELGTELDDQALTAAIREKKLSSFLPAHAALGGGGFLSTLRGRGGRNAEMEQNLVKECRSVCSSAASGSSQEPIALLRQYLRSCHNLPYYGCAFFAGEIDKPAQGLLHRGGRKAVSVGISLEGVYVMDVKEKHVLLGLKFTELSWDHSYPETEGDSHILWLEFDGEEAGTPVNKLLKIYSKQAELMSGLIEFCVELRSVSESAATGTDGEVTPSHEPTSPETNNKTRERRQGKLRRQNSVVCSRVHSLSTINYVDDGKEIKRLKPKRAASFFTRQAQPPTYSAVQVTESLEQG
Protein: Maestro heat-like repeat family member 5 (Q9DA96)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVVNKIKNMMVMEQGQVLDTICHFLEKENQLWEKPEVSFWNPSVEKLLEFLNLDPRKATDKAFFFHLYGMILRECPSVEKVQCHLASLLDLSHQHSRQREGIALAVGLASTKHLEEVWALLEHLGRTKFLQSVAATEDSQDEILKSSFLSATILLTRSLQAEYSSQRYKFTQTPELIQCLLGILQKEPNSLTNFLRQKIILVIIGLSNLRPRFKPLLKSQILKTCLQTVYMLPPAKDSRNDLFSAEQASDTTVLYKKTVRALDLLLQNFISENPSMDEVCFLLQHIEYWLMSDKIHERSRAVQSIYLLLQYVVDSLKLAKEAVPSLLGHQIGILILLWRDKDKITQQHSHFCVYLLMELVFQQKGKLVESAQWSKMKHFESNVFREWEMKLYHLVKVFKEDLTVAQHTQLILTLVHSLGSYNHLHSDLAAKLLLLICVEPGFRKEQIAELLQGLFQELPNIQSKSVQQAISQATLALGTQHIQEVVEVILSLCQPSERWILPLWKALAANYQVARDVITLLYIKLKLRPPRRLLQSTYRARLVSLMALGTIYELLYTKEYRNTVCWAFSGILLGLLTELYYLLEVGLVQGLFDYQEDDLGSKPLGPCRICLEALKGLFWTTEYWEVFADVKLIQGWELFGQLETFPKGVTLLARAMAHYNCEIKAVLGQALISLKSSEERDNIVGICIITEFLNSPDVSQHMSWKTMYNSLNLGLSSRNQMVRAMSLKGLGSTLMHPKKATLLRSKLMELLDNFLQPEFKDPAGLMKIMGHLLHCLSAQGIGIVSLKIAQHLLSLFTDERAAVREGAIFLFGDVIHYGGKKLRQSLKDVASQATVPLLFNMADPCQEVAMKARFTFLRCAILLKWEFRKELFGKLAWGQGLGAANDIFIYMLESNVGNYQQFLSQALTYLDSSHMTVKLAAMKFIGALLQDYFNDLCIYLRKKDVIFLKNCLEALRHDTDSRTRRFYLNYWNDAVELSYYVQD
Protein: Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase (EC 3.1.4.57) (Cyclic phosphate dihydrolase) (cPDH) (C8WJZ5)
Organism: Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (Eubacterium lentum)
Function: Involved in degradation of methylphosphonate. Catalyzes the hydrolysis of the phosphate ester at carbon-1 of 5-phospho-D-ribose 1,2-cyclic phosphate to form ribose 2,5-bisphosphate. This intermediate is then hydrolyzed to ribose-5-phosphate and inorganic phosphate.
Interaction partners:
- Phosphonate metabolism PhnJ
- Ribonuclease 3
- Phosphonate metabolism
Sequence:
MIEDLHVHSTMSDGSDTFEQVLEQAAQRGVERLAFTNHDTTAGLTAARELGERLGVQVVGGIEVSAYDFERGRKVHILGLGVEEGAPALAALCGSTLERRHANSLWQLDRLVEAGYEVDVERALELGRASTCLYKQHLMAALTSEPYPSAAYRTLYRSLFKNGGICDRDIDYVDARDAVRVVVEDGGLAVLAHPGQLDSYDLLPDLVECGLGGIERFHPDHTLADHARCAELAVRYRLVCTGGSDYHGKFGRVPHVGFRVPA
Protein: Protein transport protein YIF1 (YIP1-interacting factor 1) (P53845)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11157978}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:10970842, ECO:0000269|PubMed:16107716}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000269|PubMed:11157978}. Note=Also found in ER-derived COPII-coated vesicles. {ECO:0000269|PubMed:11157978}.
Interaction partners:
- Protein transport protein YIP1
- Prenylated Rab acceptor 1
- Protein transport protein YOS1
- Protein BTN2
- GTP-binding protein YPT1
- Protein BTN1
- Protein YIP4
- Integral membrane protein SED5
- t-SNARE affecting a late Golgi compartment protein 1
- Protein YIP5
Sequence:
MSYNPYAYATSEQNGVNDRFSHTPQQQRPMQIPRNTPVNGQGNANMNANVNGSGGGFPFQDPRGSMAFQLGQSAFSNFIGQDNFNQFQETVNKATANAAGSQQISTYFQVSTRYVINKLKLILVPFLNGTKNWQRIMDSGNFLPPRDDVNSPDMYMPIMGLVTYILIWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSLVELLCYVGYKFVPLILAQLLTNVTMPFNLNILIKFYLFIAFGVFLLRSVKFNLLSRSGAEDDDIHVSISKSTVKKCNYFLFVYGFIWQNVLMWLMG
Protein: TID1 (Q2TVU3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAWCSPRWLRVAVGTPRLPAAAGRGVQQPQGGVVAASLCRKLCVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTASFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCSGSGMETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTVPVPAGVEDGQTVRMPVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKGIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGKRSTGN
Protein: Large ribosomal subunit protein eL30y (60S ribosomal protein L30-2) (Q8VZ19)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- At1g43860
- Large ribosomal subunit protein uL16z
- Large ribosomal subunit protein eL32z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL39z/eL39x
- Large ribosomal subunit protein eL24y
Sequence:
MVTEKKTKKSHEGINSRLALVMKSGKYTLGYKSVLKSLRGSKGKLILISTNCPPLRRSEIEYYAMLAKVGVHHYNGNNVDLGTACGKYFRVSCLSIVDPGDSDIIKSIPGDQ
Protein: Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase XNP) (X-linked nuclear protein) (d-xnp) (dXNP) (Q9GQN5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Global transcriptional regulator. Modifies gene expression by affecting chromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:28320872}. Chromosome {ECO:0000269|PubMed:28320872}. Note=Localizes to pericentric heterochromatin associated with the X chromosome. {ECO:0000269|PubMed:28320872}.
Interaction partners:
- Daxx-like protein
- ADD domain-containing protein 1, isoform A
- DNA repair protein Rad51 homolog
- Heterochromatin protein 1
- THO complex subunit 2
- DNA replication-related element factor, isoform A
Sequence:
MGKKNPNARHTDAATPLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQELNQNQVIQLVPTYLQQLYNEMNNGDPTMYKDLLNLHSNIVHPSGMYMNPLLYANQNPNAAGYNQGTGGVPPMAGGSVAHGPPAAPAPGFEPDKVYEID
Protein: DNA transformation protein TfoY (DNA transformation protein TfoX2) (Q5E4H8)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Function: Required for efficient DNA transformation jointly with TfoX1.
Interaction partners:
- Macrodomain Ter protein
- NAD-dependent protein deacylase
Sequence:
MDKPVLKDSLRLLSSLGKITSRSMFGGFGIFIDDTMFALVVQDKLHLRASDETINLFKEQGFEPYVYKKRGFPVVTKYFAISPECWDEPDSILIQAVVALDVAKKDKEKQKSAGPSRIKDLPNLRLATERMLKKAGITTVEELKNTGSVNAYKAIQQTHSSSVSDELLWSLEGAIKGMHWSVISAETRNELRKQL
Protein: Thymidine kinase 1 (TK1) (EC 2.7.1.21) (Calmodulin-binding protein ThyB) (Q27564)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Thymidylate kinase
- Probable cytidine deaminase
- Flavin-dependent thymidylate synthase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- Uridine phosphorylase
- Uridine phosphorylase
- dihydrofolate reductase
- Cytosolic purine 5'-nucleotidase
- CTP synthase
- Peptide chain release factor 1
Sequence:
MIVTQIAGKIQVIFGPMFSGKTTELIRRIKRFNFANKKCLLIKYSKDTRYNDNIDKSFLVTHDKQNYQAFPCSILEDVKEQAQNYDVIGIDEGQFFPDVVQFSEDLANQGKTVIIAALDGTFQRKPFQSVIDLVSKAEYITKLTAVCMVCYNEAAFSKRIVESDDIELIGGIDKYISVCRGCYNSDQNEGNSTKPSKTARHSHSQSAPSVAPLAVNINPDDHLNNDY
Protein: Peroxisomal biogenesis factor 3 (Peroxisomal assembly protein PEX3) (Q9VUL8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Peroxin-19
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX16
- Peroxin 11
- RING-type E3 ubiquitin transferase
- Peroxisome biogenesis factor 2
- Peroxin-7
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX14
Sequence:
MLSRLQDFLSRHRRKFIVTGVLVGGTIFAARYAQRRFVEFQEKQAREFFERTRRTTHFESTEKTCNQVILGMGEEMCQAVLRECSTDELLEQLRQNPKNKLELWEDMKIVAFTRLATYVYASSMLVIALRVQLNLLGGYIYRDIMTEQKQVTDELKQQYLSLIRHFITDSGIRDLARYIRTQVIAVTKTIPLSEQLSLSDLEQLFWSLQMAINADTRRDPNSRMSKYLLPSQNPSHSPLLQKMVNETLDLLESEDAVGVCSHNVSRGFVLACDAIAESMGETLQHLPQAKVQTQQEQSVKFNQAGSLGASTSKSQNGLENNNLLNINRVLLALAKLIPIISGLTSRGFDTTSRPHNLPTQLLTFYVVAEKTKTLGANVYESFSSA
Protein: P-type Cu(+) transporter (EC 7.2.2.8) (F1QEG1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004166}. Membrane {ECO:0000256|RuleBase:RU362081}.
Interaction partners:
Sequence:
MALSTNLCRVTLGVEGMTCGSCVQSIEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIEDMGFESSLTNATSTPVQTETKVFSKAGCSADSVQQALSTLAQIKGVIETQESADNQGLAVTFVPSLVSEDQLGEVLKCLAPDTACRPPLSPKEGSTSRSFSGVEAVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVAGFKATVKSKPRQLKLSASEVERLLSAPKQTEEKLSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEALPPGNFKAIIPASPEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVKKDRPGSHLDHSREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTITYGAPKVVQVKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGIRCLVSNTENLLKREDSDSEENQHNAVLIQISDARAHSTEHPLIMDPQPLTVVQTASYTVLIGNREWMRRNALQVRADVDEAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIAAQVGIRKVFAEVLPSHKVAKVEQLQQEGKRVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEKLKRRLGDVRTHGSLSDVSVHIGMGELRRPSPKLSLLDRFVNYSRASINSLRSDKHSMNSMALSEPDKHSLLVGDDHCDNEIV
Protein: Pyocin-S2 (EC 3.1.-.-) (Killer protein) (Q06584)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Causes breakdown of chromosomal DNA as well as complete inhibition of lipid synthesis in sensitive cells.
Interaction partners:
- Pyocin-S2 immunity protein
- Ferripyoverdine receptor
- DUF2784 domain-containing protein
- Pyocin S5
Sequence:
MAVNDYEPGSMVITHVQGGGRDIIQYIPARSSYGTPPFVPPGPSPYVGTGMQEYRKLRSTLDKSHSELKKNLKNETLKEVDELKSEAGLPGKAVSANDIRDEKSIVDALMDAKAKSLKAIEDRPANLYTASDFPQKSESMYQSQLLASRKFYGEFLDRHMSELAKAYSADIYKAQIAILKQTSQELENKARSLEAEAQRAAAEVEADYKARKANVEKKVQSELDQAGNALPQLTNPTPEQWLERATQLVTQAIANKKKLQTANNALIAKAPNALEKQKATYNADLLVDEIASLQARLDKLNAETARRKEIARQAAIRAANTYAMPANGSVVATAAGRGLIQVAQGAASLAQAISDAIAVLGRVLASAPSVMAVGFASLTYSSRTAEQWQDQTPDSVRYALGMDAAKLGLPPSVNLNAVAKASGTVDLPMRLTNEARGNTTTLSVVSTDGVSVPKAVPVRMAAYNATTGLYEVTVPSTTAEAPPLILTWTPASPPGNQNPSSTTPVVPKPVPVYEGATLTPVKATPETYPGVITLPEDLIIGFPADSGIKPIYVMFRDPRDVPGAATGKGQPVSGNWLGAASQGEGAPIPSQIADKLRGKTFKNWRDFREQFWIAVANDPELSKQFNPGSLAVMRDGGAPYVRESEQAGGRIKIEIHHKVRIADGGGVYNMGNLVAVTPKRHIEIHKGGK
Protein: Novel spermatogenesis regulator, isoform A (Novel spermatogenesis regulator, isoform B) (Q9W224)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
METQSEFTEEQNQDQPTQDQPTYQPRLNEVAQKFLADLDEERKRLSAEFPLCALLIDESVDRVFSTGRIPGKEFYADVYHQRPMKITQKVFVPVNKFPKFNFARKILGPKGNSVRRLKEETNCKIVIKGRSSMRDRNKEEELRSSGDPRYAHLHKDLFLEVSAVAPPAECYARIAYALAEIRKYLIPDDNDDVWHEQQRELMEMNPESAKKSNGLNMAPYRSIFDKTIGGNRNGAPKYNNQIRRVTENPREVADMEEVEYDYDEHRMPPSRPSLGFEYSKPPPSMTATNATPFKRAYPYPTDMNRTREPPIKSYKPNPYTILNKYINNRAPSDFVAQRYN
Protein: Transmembrane protein 248 (Q9NWD8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFSINPLENLKVYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTTTPESTMTSGQARASTQSPQALEDSGPVNISVSITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPTAWSSDDCALHGHCEQVVFTACMTLTASPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALAEA
Protein: Adenine permease AdeQ (P31440)
Organism: Escherichia coli (strain K12)
Function: High-affinity transporter for adenine.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}.
Interaction partners:
- Uric acid transporter UacT
- Xanthine permease XanQ
- Putative purine permease YbbY
- Putative pyrimidine permease RutG
- Xanthine permease XanP
- Uncharacterized protein YgjJ
- Adenine deaminase
- Uracil permease
Sequence:
MNNDNTDYVSNESGTLSRLFKLPQHGTTVRTELIAGMTTFLTMVYIVFVNPQILGAAQMDPKVVFVTTCLIAGIGSIAMGIFANLPVALAPAMGLNAFFAFVVVGAMGISWQTGMGAIFWGAVGLFLLTLFRIRYWMISNIPLSLRIGITSGIGLFIALMGLKNTGVIVANKDTLVMIGDLSSHGVLLGILGFFIITVLSSRHFHAAVLVSIVVTSCCGLFFGDVHFSGVYSIPPDISGVIGEVDLSGALTLELAGIIFSFMLINLFDSSGTLIGVTDKAGLIDGNGKFPNMNKALYVDSVSSVAGAFIGTSSVTAYIESTSGVAVGGRTGLTAVVVGVMFLLVMFFSPLVAIVPPYATAGALIFVGVLMTSSLARVNWDDFTESVPAFITTVMMPFTFSITEGIALGFMSYCIMKVCTGRWRDLNLCVVVVAALFALKIILVD
Protein: Gamma-aminobutyric acid receptor subunit beta (Ionotropic GABA receptor subunit UNC-49C) (G5EE10)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MARPFTLIVLLSAHLCLHVVVTQDEDSHINTQLLSSVLDRLTNRTTYDKRLRPRYGEKPVDVGITIHVSSISAVSEVDMDFTLDFYMRQTWQDPRLAFGSLDLGLSKEIDSLTVGVDYLDRLWKPDTFFPNEKKSFFHLATTHNSFLRIEGDGTVYTSQRLTVTATCPMDLKLFPMDSQHCKLEIESYAYSTAEIEYKWCTSKEPNCSTAVKADANIELSSYKFTKICQKRTLASTSSGTYSRLRVSFIFDRDSGFYFLQIFFPASLVVVLSWISFWINRDSAPSRTLIGTMTVLTETHLMTGTNRRLPPVAYVKAVDVFLGFCYLLVILALIEYACVAYSKKKNEDRRRREKKTEHKPAPPTPDILHDVRLAECTCNAAPTSIIAVIKQSNRFCVSHSHIDIVSRAAFPLVFILFNTLFWLILLYKSKRLPYISEHEGDRCDAPDLH
Protein: E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5) (P39940)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other cell surface proteins like GAP1, FUR4, MAL61, PMA1 and STE2. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription, pressure-induced differential regulation of the two tryptophan permeases TAT1 and TAT2 and sorting efficiency into multivesicular bodies. The RSP5-UBA1-UBC5 ubiquitin ligase complex ubiquitinates RPO21 forming 'Lys-63'-linked polyubiquitin chains. Plays a role in tolerance to o-dinitrobenzene. Involved in actin cytoskeleton organization and dynamics. Ubiquitinates the LAS17-binding proteins LSB1 and PIN3/LSB2 without directing them for degradation and affects LAS17 levels in a SLA1-dependent and LSB1/2-independent manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22000681}. Nucleus {ECO:0000305}. Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:22000681}.
Interaction partners:
- Polyubiquitin
- Ubiquitin ligase-binding protein BUL1
- Ubiquitin ligase-binding protein BUL2
- Protein SNA3
- Ubiquitin-ribosomal protein eS31 fusion protein
- Protein ROD1
- Ubiquitin carboxyl-terminal hydrolase 2
- Protein ROG3
- Ubiquitin-conjugating enzyme E2 4
- Protein SPT23
Sequence:
MPSSISVKLVAAESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKKTLNPYWNETFKFDDINENSILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITRDLKKSNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSSTTRTNGHSTSSTRNHSTSHPSRGTAQAVESTLQSGTTAATNTATTSHRSTNSTSSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNTRTTTWKRPTLDQTEAERGNQLNANTELERRQHRGRTLPGGSSDNSSVTVQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE
Protein: Uncharacterized protein (Q57WH4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRRAAPAGGIIARWGLSNCNVSIRHGRHGLTRHDFSNVFSRSLTEEEMKALQQQQEYRPVSAVVPGKLFMRHWIAGEQATESVVDRVISGFVFVCFMLWGCGFATLGFNGNSCAHTAVLVFIAYWLYLQTHCRLLISALATLAVLHLIVN
Protein: Malate synthase (EC 2.3.3.9) (C5MBE7)
Organism: Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
- Isocitrate lyase
- Citrate synthase
- malate dehydrogenase
- Acetyl-coenzyme A synthetase
- Acetyl-coenzyme A synthetase
- Malate dehydrogenase
- Phosphoenolpyruvate carboxykinase
- Malate dehydrogenase
- Malate dehydrogenase
- fumarate hydratase
Sequence:
MSTPFPKTADKVKGVQILGPIPDDAKHIFNQETLAFVATLHRGFEARRQELLNNRKEQQKLRDQGFLPDFLPETEYIRNDPTWTGPALAPGLIDRRCEITGPTDRKMVINALNSNVATYMADFEDSLTPAWKNLVEGQVNLYDAVRRNLTANINGKQYALNLDKGRHIPTLIVRPRGWHLTEKHVLVDGTPVSGGIFDFAVYFYNSAKEAIAQGFGPYFYLPKMEHHLEAKLWNDIFNYSQDYIGLKRGTIRASVLIETIPAVFQMDEIIYQLREHSAGLNCGRWDYIFSYIKCLRNHPDFILPDRSQVTMAAPFMSSYVKLLVHTTHKRKVHALGGMAAQIPIKDDEARNRAALENVTKDKLREVTLGCDSCWVAHPALVPVVLKVFNEHMKGPNQISLPPKEPFKPITQRDLLSPFVPGAKITEQGIRANIVIGISYIEAWLRNVGCVPINYLMEDAATAEVSRTQIWQWVTHGAKTDTGKVITKDYVKQLLDEEYDKLVKNAKPGNKFKRAFEYFAPEALGEKYSDFVTTLIYDDVTTIGRALPGERL
Protein: Aldehyde reductase, putative (EC 1.1.1.21) (Q8ID61)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Nucleoporin NUP221, putative
- Protein transport protein SEC13
- Aquaglyceroporin
- Uncharacterized protein
- Ribosomal protein L37
Sequence:
MPRLVIFYFLIFVFMKINCINYNSFSKRKINYHLIRDKQENIKYKYLREDEKLNLSRRNRTKRTKETNGGTQRIKRIKRIKRIKRIKRNNLSNIFYNKNDYMIKKINVPRTYFIKNMGNSSLKGCIYKEKKTIFNIYNIYDDKNIMNPKNFGNEDGNLLNKLGNDYSDKDSYNKNMNDKKQIVLDNKNEKMYIENMKKNLSRTDEVTYKYVEEMELKKINIKGVDIQYRLYNLEEGIYIVDKENYEKIKKLWDKDELKKAKENFEDTFDIKKQGIKDEDWIMLPFEYEENKNIKLVKADFDNPTYDYILTYYDKERNYYWEYKRRNYYKMFKNTVHETPPYKSDLEEDKRYYGKEIIIPKKKLDNDIFRQPMLSDVMTSGCNREPLGFESWRFVKYPYGNLIESQKYSKLYCVKKNDKDKPSMKYHYLGNSNLAVSEICLGTMNFGNYVNEKLAHELFDYAFEEFQVNFFDTAEIYPLPASENYYGHSEEILGNWLEAKGKANRHKFVIATKICGRTDKLPWMKKYKIRTEQKNILNKRNADIYNDNNYKKDHYITNSKSNEYSHRNNNHMLDKEDNKNGYDKLKELKEKEELYLKKDYDKINKFEEYEKERLDNSANLITLNKENIINSVDNCLKRLKTSYIDLLQLHWPDRYYPDQSSGDFSHVLYDYNKYYDDFIPFIEQLQALDELKKKGKIREWGLSNETPFGLLKFYELCKHLHISPPVSVQLEYNLLCRNDVEKGFPEICRPQNTNISILAYSPLCAGILTGKYLEYTDYTTKGRMQKFPSYMKRLRGSIATYIIRELYYLSQKYYFPNLTVAALKWVYTRSFITSTIIGVSDFLQLRENLYSLTNEVLFTDKLEREINALHWKFRDPIRIIQ
Protein: Neuronal acetylcholine receptor subunit alpha-6 (P43143)
Organism: Rattus norvegicus (Rat)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000269|PubMed:21325521}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuronal acetylcholine receptor subunit beta-3
- Tyrosine-protein kinase JAK2
- Neuronal acetylcholine receptor subunit alpha-4
- Acetylcholine receptor subunit alpha
- Acetylcholine receptor subunit epsilon
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit alpha-3
- Neuronal acetylcholine receptor subunit alpha-7
- Neuronal acetylcholine receptor subunit alpha-5
- Neuronal acetylcholine receptor subunit alpha-2
Sequence:
MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS
Protein: Insulin gene enhancer protein ISL-2 (Islet-2) (Q96A47)
Organism: Homo sapiens (Human)
Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- LIM/homeobox protein Lhx4
- LIM/homeobox protein Lhx3
- LIM domain-binding protein 1
- Single-stranded DNA-binding protein 3
- Single-stranded DNA-binding protein 2
- Single-stranded DNA-binding protein 4
- Motor neuron and pancreas homeobox protein 1
- Neurogenin-2
- Isopentenyl-diphosphate delta-isomerase 2
- Glycerophosphodiester phosphodiesterase domain-containing protein 5
Sequence:
MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET