wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor PIF5 (Basic helix-loop-helix protein 65) (AtbHLH65) (bHLH 65) (Phytochrome interacting factor-like 6) (Phytochrome-interacting factor 5) (Transcription factor EN 103) (bHLH transcription factor bHLH065) (Q84LH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor acting negatively in the phytochrome B signaling pathway to promote the shade-avoidance response. Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin-proteasome pathway. Promotes ethylene activity in the dark. May regulate the expression of a subset of genes by binding to the G-box motif. Might be involved in the integration of light-signals to control both circadian and photomorphogenic processes. Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e.g. hypocotyl elongation in low blue light).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:26724867}.
Interaction partners:
- Phytochrome B
- Transcription factor PIF4
- DELLA protein RGA
- DELLA protein GAI
- Cryptochrome-2
- DELLA protein RGL2
- DELLA protein RGL1
- DELLA protein RGL3
- Transcription factor PIF3
- Cryptochrome-1
Sequence:
MEQVFADWNFEDNFHMSTNKRSIRPEDELVELLWRDGQVVLQSQARREPSVQVQTHKQETLRKPNNIFLDNQETVQKPNYAALDDQETVSWIQYPPDDVIDPFESEFSSHFFSSIDHLGGPEKPRTIEETVKHEAQAMAPPKFRSSVITVGPSHCGSNQSTNIHQATTLPVSMSDRSKNVEERLDTSSGGSSGCSYGRNNKETVSGTSVTIDRKRKHVMDADQESVSQSDIGLTSTDDQTMGNKSSQRSGSTRRSRAAEVHNLSERRRRDRINERMKALQELIPHCSRTDKASILDEAIDYLKSLQMQLQVMWMGSGMAAAAAAAASPMMFPGVQSSPYINQMAMQSQMQLSQFPVMNRSAPQNHPGLVCQNPVQLQLQAQNQILSEQLARYMGGIPQMPPAGNQMQTVQQQPADMLGFGSPAGPQSQLSAPATTDSLHMGKIG
Protein: Transcriptional activator/repressor MOT3 (Hypoxic gene repressor protein 7) (Modulator of transcription protein 3) (P54785)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that affects the expression of a large set of genes. Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region. Plays a major role in the repression of a specific subset of hypoxic genes (e.g. ANB1, DAN1 and HEM13) under aerobic conditions. Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes. Represses transcription of ergosterol biosynthetic genes. Negatively regulates pheromone-induced gene expression. Can act as a transcriptional activator (e.g. of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter).
Subcellular location: Nucleus {ECO:0000269|PubMed:9611199}.
Interaction partners:
- Repressor ROX1
- General transcriptional corepressor CYC8
- SWI/SNF chromatin-remodeling complex subunit SWI1
- Eukaryotic peptide chain release factor GTP-binding subunit
- 3-isopropylmalate dehydrogenase
- Sterol regulatory element-binding protein ECM22
- Transcriptional regulator URE2
- Sterol uptake control protein 2
- [PIN+] prion protein RNQ1
- Regulatory protein LEU3
Sequence:
MNADHHLQQQQQQRQQHQQQQHQQQQHQHQHQQQQHTILQNVSNTNNIGSDSLASQPFNTTTVSSNKDDVMVNSGARELPMPLHQQQYIYPYYQYTSNNSNNNNVTAGNNMSASPIVHNNSNNSNNSNISASDYTVANNSTSNNNNNNNNNNNNNNNIHPNQFTAAANMNSNAAAAAYYSFPTANMPIPQQDQQYMFNPASYISHYYSAVNSNNNGNNAANNGSNNSSHSAPAPAPGPPHHHHHHSNTHNNLNNGGAVNTNNAPQHHPTIITDQFQFQLQQNPSPNLNLNINPAQPLHLPPGWKINTMPQPRPTTAPNHPPAPVPSSNPVASNLVPAPSSDHKYIHQCQFCEKSFKRKSWLKRHLLSHSQQRHFLCPWCLSRQKRKDNLLQHMKLKHTNYLLDELKKNNIIFNYNNSSSSNNNNDNNNNNNSNSASGSGGAGAAAAAATAPENEDGNGYDTNIKTLINDGVLNKDDVKRVLNNLIVSHNK
Protein: Small ribosomal subunit protein uS11x (40S ribosomal protein S14-3) (P42036)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein uS15z
- Small ribosomal subunit protein eS26y
- Small ribosomal subunit protein uS17x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS13z/uS13y/uS13x
- Small ribosomal subunit protein eS6z
Sequence:
MSKRKTKEPKVENVTLGPAVREGEQVFGVVHVFASFNDTFIHVTDLSGRETLVRITGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITAIHVKLRATGGNKTKTPGPGAQSALRALARSGMKIGRIEDVTPIPTDSTRRKGGRRGRRL
Protein: Guanine nucleotide exchange factor VAV2 (VAV-2) (Q60992)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Interaction partners:
- Lymphocyte cytosolic protein 2
- Cell division control protein 42 homolog
- Transforming protein RhoA
- Tyrosine-protein kinase SYK
- Catenin delta-1
- Ras-related C3 botulinum toxin substrate 2
- B-cell linker protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Tyrosine-protein kinase ZAP-70
- Ras-related C3 botulinum toxin substrate 3
Sequence:
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSLEELADEHDLGEDIYDCVPCEDEGDDIYEDIIKVEVQQPMKMGMTEDDKRSCCLLEIQETEAKYYRTLEDIEKNYMGPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSMMAGGSTLAKVFLEFKERLLIYGEYCSHMEHAQSTLNQLLASREDFRQKVEECTLRVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQCSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEVIELLFHKMTDDPMHNKDIKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTRCGVGAHKECLEVIPPCKMSSPADVDAPGAGPGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLRGDPDSPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPTGRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWIHITEAKKFESLLELVEYYQCHSLKESFKQLDTTLKFPYKSRERTTSRASSRSPASCASYNFSFLSPQGLSFAPQAPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGVQ
Protein: Protein AF-9 homolog (Q10319)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376}.
Interaction partners:
- SWR1-complex protein 4
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein eaf3
- SWR complex protein 2
- Probable chromatin modification-related protein eaf7
- RuvB-like helicase 1
- NuA4 acetyltransferase complex subunit Tra2
- Histone H2A.Z
- Helicase swr1
- Chromatin modification-related protein png1
Sequence:
MAPNTRVSKCQISRPILVGNDAKPLTKEEKEKAPTDHTHTWRIFVEGVDGEDISKWVRKVVFKLHDTYNNPTRTIESPPFEVIETGWGEFDIMVRIFFAPEAHEKALTFYHHLKLHPYGPRMEEMKASGGLVESVQYEEIVFNEPFEYTYKLLSQNPIGDGHGLAVESEPDHPFSQQLEQDEADKLDFAIQEVKKTIEMYKQQVQSLQGQKSSTPVE
Protein: 17.4 kDa class III heat shock protein (17.4 kDa heat shock protein 2) (AtHsp17.4B) (Q9SYG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 23.5 kDa heat shock protein, mitochondrial
- Heat shock 70 kDa protein 8
- Chaperone protein ClpB1
- HSP20-like chaperones superfamily protein
- Ankyrin repeat family protein
- Heat stress transcription factor A-2
- Heat shock 70 kDa protein 5
- NADPH-dependent aldehyde reductase 1, chloroplastic
- DNA ligase
- Probable aldo-keto reductase 1
Sequence:
MSAVAINHFFGLPEAIEKLILPISRSGESNNESRGRGSSNNIPIDILESPKEYIFYLDIPGISKSDIQVTVEEERTLVIKSNGKRKRDDDESEEGSKYIRLERRLAQNLVKKFRLPEDADMASVTAKYQEGVLTVVIKKLPPQPPKPKTVQIAVS
Protein: Cation channel sperm-associated auxiliary subunit TMEM262 (Cation channel sperm-associated auxiliary subunit eta) (Transmembrane protein 262) (E9PQX1)
Organism: Homo sapiens (Human)
Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D3Z338}.
Interaction partners:
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated protein 4
- Cation channel sperm-associated auxiliary subunit epsilon
- Cation channel sperm-associated auxiliary subunit gamma
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated protein 3
- Cation channel sperm-associated protein 2
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated auxiliary subunit zeta
Sequence:
MWLQDRIATFFFPKGMMLTTAALMLFFLHLGIFIRDVHNFCITYHYDHMSFHYTVVLMFSQVISICWAAMGSLYAEMTENKYVCFSALTILMLNGAMFFNRLSLEFLAIEYREEHH
Protein: Jade family PHD finger 2 (PHD finger protein 15, isoform CRA_d) (G3XAA4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSKGSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
Protein: Visual system homeobox 1 (Transcription factor VSX1) (O42250)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11331779}.
Interaction partners:
- Transcription factor atoh7
- Pancreas transcription factor 1 subunit alpha
- Basic helix-loop-helix family, member e23
- Insulin gene enhancer protein isl-1
- POU domain protein
- Forkhead box protein N4
Sequence:
MTGREEATDEKPKVKLYPSFGIDKSRLNGSGFRSKGFAITDLLGLESELQPHQSGPGAGPNGEGQSAAVGGFSFPGGSLPLGLGFLCSLAAQQPPGAPCFLPSHIPLLQSRTESHFMQNLEQQRDVYSDDDCLSGDRNDGKNSGNSQKRKKRRHRTVFTSHQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESIINSAKSGMMGSCAPWLLGEPAGMHKKSMEIVKKAPGTPESTHSDTYSEEHKGKDSDTTWSSGANGADDSEDMAIDLSSTSKQENKSTLKRSPPRTENSSDSENES
Protein: Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) (Q16658)
Organism: Homo sapiens (Human)
Function: Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21706053, ECO:0000269|PubMed:9571235}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21685497}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:3525578, ECO:0000269|PubMed:9571235}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21706053}. Cell projection, filopodium {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:3525578}. Cell projection, invadopodium {ECO:0000269|PubMed:20137952}. Cell projection, microvillus {ECO:0000269|PubMed:9571235}. Cell junction {ECO:0000269|PubMed:9571235}. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q61553, ECO:0000269|PubMed:21706053}.
Interaction partners:
- Espin
- Filamin-A
- Ras-related protein Rab-35
- Catenin beta-1
- Angiopoietin-related protein 4
- Plastin-2
- RAC-alpha serine/threonine-protein kinase
- Filamin-C
- Filamin-B
- Actin nucleation-promoting factor WASL
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
Protein: Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) (Q9C040)
Organism: Homo sapiens (Human)
Function: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36481767}.
Interaction partners:
- Neurofilament light polypeptide
- Tripartite motif-containing protein 3
Sequence:
MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ
Protein: Floral homeotic protein AGAMOUS-like isoform X3 (MADS-box protein MADS4) (A2IBU9)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVYPNESLEDSPQKKMGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSNRGRLYEYANNSVKATIERYKKASDSSNTGSVAEVNAQFYQQEADKLRNQIRNLQNTNRHMLGESVGGLPMKELKSLETRLEKGISRIRSKKNELLFAEIEYMQKKEIDLHNNNQLLRAKIAENERKQESMNLMPGGSSNNFEAIHSQPYDSRNYFQVDALQPAANYYNPQQQQDQIVLQLV
Protein: Probable 9-cis-epoxycarotenoid dioxygenase NCED5, chloroplastic (AtNCED5) (EC 1.13.11.51) (Q9C6Z1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid biosynthesis from carotenoids (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:12834401, ECO:0000269|PubMed:15340011}.
Interaction partners:
- Xanthoxin dehydrogenase
- Zeaxanthin epoxidase, chloroplastic
- Abscisic-aldehyde oxidase
- Phytoene synthase 1, chloroplastic
- Molybdenum cofactor sulfurase
- Abscisic acid 8'-hydroxylase 1
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- Protein phosphatase 2C 56
- Protein ABSCISIC ACID-INSENSITIVE 5
- Abscisic acid 8'-hydroxylase 2
Sequence:
MACSYILTPNPTKLNLSFAPSDLDAPSPSSSVSFTNTKPRRRKLSANSVSDTPNLLNFPNYPSPNPIIPEKDTSRWNPLQRAASAALDFAETALLRRERSKPLPKTVDPRHQISGNYAPVPEQSVKSSLSVDGKIPDCIDGVYLRNGANPLFEPVSGHHLFDGDGMVHAVKITNGDASYSCRFTETERLVQEKQLGSPIFPKAIGELHGHSGIARLMLFYARGLFGLLNHKNGTGVANAGLVYFHDRLLAMSEDDLPYQVRVTDNGDLETIGRFDFDGQLSSAMIAHPKIDPVTKELFALSYDVVKKPYLKYFKFSPEGEKSPDVEIPLASPTMMHDFAITENFVVIPDQQVVFKLSDMFLGKSPVKYDGEKISRFGILPRNAKDASEMVWVESPETFCFHLWNAWESPETDEVVVIGSCMTPADSIFNECDEQLNSVLSEIRLNLKTGKSTRRTIIPGSVQMNLEAGMVNRNLLGRKTRYAYLAIAEPWPKVSGFAKVDLSTGEVKNHFYGGKKYGGEPFFLPRGLESDGEDDGYIMSFVHDEESWESELHIVNAVTLELEATVKLPSRVPYGFHGTFVNSADMLNQA
Protein: Alpha/beta-Hydrolases superfamily protein (F4IZK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 98A3
- F5F19.5 protein
- Flavone 3'-O-methyltransferase 1
- Shikimate O-hydroxycinnamoyltransferase
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- 4-coumarate--CoA ligase 4
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Cytochrome P450 84A1
- Probable caffeoyl-CoA O-methyltransferase At4g26220
Sequence:
MMKFKFQYEEEYIKNSRDVELFACRWLPSSSPRALVFLCHGYGMECSSFMRECGIRLASAGYAVFGMDYEGHGRSKGARCYIKKFSNIVNDCFDYYTSISAQEEYKEKGRFLYGESMGGAVALLLHKKDPSFWNGALLVAPMCKISEKVKPHPVVINLLTRVEDIIPKWKIVPTKDVIDAAFKDPVKREEIRNNKLIYQDKPRLKTALEMLRTSMDLEDTLHEITLPFFVLHGEADIVTDPEISKALFEKASTRDKTIKLYPGMWHGLTSGEPDANVDLVFADIVNWLDARTGDSASLTVTPVHDFTSNVQKVVDGVSNGQGKSKRPQASLLCGLNGGGRRLVHRSSM
Protein: Tissue factor pathway inhibitor (Q1WCN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|PIRNR:PIRNR001620}.
Interaction partners:
- Thrombomodulin.
- Antithrombin-III
Sequence:
MACDLLGALLLFISVLESAVGLTLQPKEVCLLQIEEGTCNDDIQRFYYNTISQQCEEFSYSGCGGNQNNFRSFVECQKTCFRIPKIPQICRFQKKEGPCRGLFSRYFFNMTSMQCEPFTYGGCQGNENNFRNPEECIEYCKPPKTIPVICLDNLDKGRCSASIPRYYYNSATKTCEEFMYTGCGGSNNNFISKQSCVDVCGSKRWSPTKKSVRVSKQYLRRVKPQPSREKTNK
Protein: Zinc finger protein 333 (Q96JL9)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription intermediary factor 1-beta
Sequence:
MESVTFEDVAVEFIQEWALLDSARRSLCKYRMLDQCRTLASRGTPPCKPSCVSQLGQRAEPKATERGILRATGVAWESQLKPEELPSMQDLLEEASSRDMQMGPGLFLRMQLVPSIEERETPLTREDRPALQEPPWSLGCTGLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWLQEDKVEEEAMAPGLPTACSQEPVTFADVAVVFTPEEWVFLDSTQRSLYRDVMLENYRNLASVADQLCKPNALSYLEERGEQWTTDRGVLSDTCAEPQCQPQEAIPSQDTFTEILSIDVKGEQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAGEASCECQEIRNSFFQSAHLIVPEKIRSGDKSYACNKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRHMRTHTGEKPFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRSHVRTHTGEKPFECSQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEKPYVCQECGRAFSEPSSLRKHARTHSGKKPYACQECGRAFGQSSHLIVHVRTHSAGRPYQCNQCEKAFRHSSSLTVHKRTHVGRETIRNGSLPLSMSHPYCGPLAN
Protein: Histidinol dehydrogenase (HDH) (EC 1.1.1.23) (Q9P777)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Interaction partners:
- Histidine biosynthesis bifunctional protein his7
- ATP phosphoribosyltransferase
- Imidazoleglycerol-phosphate dehydratase
- 1-
- Histidinol-phosphate aminotransferase
- Probable histidinol-phosphatase
- Tryptophan synthase
- Imidazole glycerol phosphate synthase hisHF
- Homoserine dehydrogenase
- Ergothioneine biosynthesis protein 1
Sequence:
MPEYEIQVPSYRAAALTAEERTRLLARPIQNTQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKSAVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINRVGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAIILAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLVIADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIKHAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMGDYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAHADAVRVRGVRL
Protein: 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) (P09543)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P16330}; Lipid-anchor {ECO:0000250|UniProtKB:P16330}. Melanosome {ECO:0000269|PubMed:12643545}. Note=Firmly bound to membrane structures of brain white matter. {ECO:0000250|UniProtKB:P16330}.
Interaction partners:
- Myelin basic protein
- Glial fibrillary acidic protein
- Myelin-associated glycoprotein
- Myelin proteolipid protein
- Myelin-oligodendrocyte glycoprotein
- Oligodendrocyte transcription factor 2
- DnaJ homolog subfamily C member 7
- Galactocerebrosidase
- Outer dynein arm-docking complex subunit 4
- Oligodendrocyte transcription factor 1
Sequence:
MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTII
Protein: Candida glabrata strain CBS138 chromosome H complete sequence (Q6FS27)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MVKVAIITYSCYGHITTIAREIKKGVEAAGGEVTLFRVPETLPDDVLEQMNAAEKPEDFLIANGETLTDYDAFLFGVPTRFGNVPSQWAEFWDKTGAIWVQGSLWGKPAGVFVSTGTYGGGQEATVKTCMNYLVHHGMVFVPLGYKYTFAELSNVEDIHGGSPWGAGTLAGADGSRQPSSLELRMAKTQGKTFYETASKLCDKKPSTKSSKNMDSKPSAKQNTSATGKAEVKTSGTTTQQKPTETRPKEKTKFNPSKNCVIM
Protein: Stearoyl-CoA desaturase 2 (EC 1.14.19.1) (Acyl-CoA desaturase 2) (Delta(9)-desaturase 2) (Delta-9 desaturase 2) (Fatty acid desaturase 2) (Q6P7B9)
Organism: Rattus norvegicus (Rat)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates. Important for normal permeability barrier function of the skin in neonates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13011}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13011}. Microsome membrane {ECO:0000250|UniProtKB:P13011}.
Interaction partners:
- Fatty acid synthase
Sequence:
MPAHILQEISGSYSATTTITAPPSGGQQNGGEKFEKNPHHWGADVRPEIKDDLYDPSYQDEEGPPPKLEYVWRNIVLMALLHIGALYGITLVPSCKVYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSKAAVLARIKRTGEESCKSG
Protein: Protein ZAR1-like 1.S (Zygote arrest protein 1-like 1.S) (A0A1L8HBI7)
Organism: Xenopus laevis (African clawed frog)
Function: mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation. Controls timing of meiosis during oogenesis. Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation.
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:36278895}.
Interaction partners:
Sequence:
MAGLVYPQYPVFPGYRQPYRQLPPFYKPKQPYWKPPYKGVPGPMKPTNPLDCLDGYKWAQLKALLSQLGPEFGLGRRFTKEVGVQVNPRVDACIQCSLGPRTLKNCKGGPFLFHAVPGQHAGLGIIAPVRFPRTTAVYSRLSDRRLFTLPTPTYGGKKEGGTQMDPVEEDLLLKRPTFQFLEQKYGFFQCKDCQIRWESAYVWCVSGTNKVYFKQFCHKCQKGHNPYYVESIECKRCKKAWCSCPERRHIDLKRPHCQDLCGRCKGQRLSCDKTFSFKYII