wanglab/gogpt-training-data huggingface dataset:
Protein: Calmodulin-binding transcription activator homolog 1 (H2KY84)
Organism: Caenorhabditis elegans
Function: Transcription factor. Positively modulates neuronal levels of the ubiquitous Ca2+ sensor calmodulin/cmd-1, probably by direct binding to the cmd-1 promoter, thereby regulating Ca2+ signaling, physiology, and behavior.
Subcellular location: Nucleus {ECO:0000305|PubMed:34499028}.
Interaction partners:
- Uncharacterized protein.
- Putative serine/threonine-protein kinase C01C4.3
- MADF domain-containing protein
- C3H1-type domain-containing protein
- Uncharacterized protein
- Probable glycerol kinase
Sequence:
MNNSVTRLLFKRLLTLQLCHHFDIIPHRDQSFDCVQMQQPQNETANNFIPSIQLLWSTDPPQIRPDGTYPQAVELFPCFKDKWNTKEEILNIILAANADPKSNCVTVQSSPRPCSSSQFIYPRLDNAWYKNDGYIWKKRTNGKQNREDHLNLKISGHPHISAKYIHSAIVPTFHRRSYSVPDSDCHVLVHYLNVKTNNKIDDQAEEIARSMIENKVFISLSQLHDQLSPIFLQTLNVNQLVAEINEHLKKKGVNLPTSPLPQEPSSSTSRELERRNSCSSAFRKGLSSVALRRQPSANSEIDANHIGTMLKRFGCNGSSSDRISIIQPTMQNFQSIRSHQNHVAMESRSPSGDGDSRPITFEEDASYQQLSIKSSTNVSTPASAFAEKMKIRSGSQESPMGPPSSSSVTSTSLIPIIEMTPSSSSLKGGQKMLVVGGYYRKGHEYKISFGRGRMMPAVLIHAGVLSCVIPPSAKPEVVQIRVFCNGQAISTASEFTYEPQSAHLIKENDDTLVQIFEKIRIMACAFNAYSSIENIQSSSCMESLLANIVQQIDNEVSSQNLNYKTELLNGSAHFPSKTVLHLVASLDYDRLFEALIDLSRKVPACREFDIFARDNDGSTPLHTACKNSASRIARLIISIDSSAIDVVDDRGRTPVEVAPEHSIDMLSDKNNEEERVNATELWVMTNGKAFTTDKILDGKISRAPIAEKPDDLLREATSSYSIMSEMYEGPMLQAGTSRECDEDCESCCDPDSTQQLHVEIAMDTDVHVPDSPKMARLFHAVTSPGIVVPPNARARMADLARQIIEALPDRIKRNSEVSMCPDEEDPGQNHHGGVEPMFYQQASCSMSTDSPNMMDDYFDMMATETRNDIFTEPRSTETTETSASKSAQLFATHCNFFDDRSFASSSTRANTFESDTLDFDKDLGEFFTIHVDRFVDPIQQRLANLKYNDDEQRDVYEAAMVIQRAYRVYRARSTTRRQEDIERRAALKIQGCYRRYKQFCYFKKLHNAAIVVQKHFRMRKRDDKEEGAVEAVIASVPEHPTLDGQSICIQVPKTNSTMLRERAATTIQVAYRYRHRKRQAAARKIQNFMRQNRNNVNIDDGHTQHLIAENACAKRRRYVACPQTSGDQRNKRDSDGERKRDAHHDAPEFIPIGATPSSTTIPHRPTQRHHPWDQLKPPYGCGTLA
Protein: PHAryngeal gland Toxin-related (Q22373)
Organism: Caenorhabditis elegans
Interaction partners:
- ShKT domain-containing protein
- Zinc metalloproteinase nas-14
- Putative tyrosinase-like protein tyr-1
Sequence:
MTACRLVAILFLVFTVGEAAEDCVDLLSTCESLQSICIGSVLEYHFNVISDLSKQLNSSSLPALETSLPLIQSGLPLVLGSNGGDEGSAEGSAVEGSGSSSSSSVFDEQNLKNALPLLKESLPLIRESLPLIRESLPLIRQYLDPLVGKSYCQRKATCRSCKDCPKLRDSIVDFVQALCPRTCKVCTTGSDLLASSAALTAFFS
Protein: phosphatidate phosphatase (EC 3.1.3.4) (Q5XIM8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Phospholipid phosphatase 2
- Diacylglycerol O-acyltransferase 1
- Phospholipid phosphatase 3
- Diacylglycerol O-acyltransferase 2
- Peroxisome proliferator-activated receptor alpha
- phosphatidate phosphatase
- Serine/threonine-protein kinase mTOR
- Choline/ethanolaminephosphotransferase 1
- Lipoprotein lipase
- phosphatidate phosphatase
Sequence:
MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMYLATSPILSEGASRMESQLKRNSVDRIRGLDPTTAAQGLPPSDTPSTGSLGKKRRKRRRKAHLDNLKRDDNVNTSEDEDMFPIEMSSDEDTALMDGSRALPNDVPPFQDDIPKENLPSISTYPQSASYPNSDREWSPSPSSLVDCQRTPPHLAEGVLSSSCPLQSCHFHASESPSGSRPSTPKSDSELVSKSADRLTPKNNLEMLWLWGELPQAAKSSSPHKMKDSSPLGGRKMADKIHFQTIHSESSDTFSDQSPTMARGLLIHQSKAQTEMQFVNEEDLEALGAAAPPLSVAEELKAPASSTAQTSSKSDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPGGLPKQASDNGARSANQSPQSVGSSGIDSGVESTSDSLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFADNPAIIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNATIKEESKPEQGLPGKGHNTGEQPAQLGLTTRIKHESSSSDEEHSATKPSSSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSCDFPCSDTFSNFTFWREPLPPFENQDVHSASA
Protein: Protein cornichon homolog 4 (CNIH-4) (Cornichon family AMPA receptor auxiliary protein 4) (Q9P003)
Organism: Homo sapiens (Human)
Function: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:24405750}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:24405750}.
Interaction partners:
- Voltage-dependent calcium channel gamma-8 subunit
- Glutamate receptor 1
- Glutamate receptor 3
- Glutamate receptor 2
- Cytosolic 5'-nucleotidase 1A
- Protein shisa-9
- Glutamate receptor 4
- Voltage-dependent calcium channel gamma-2 subunit
- Germ cell-specific gene 1-like protein
Sequence:
MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMILALIND
Protein: Pcdh11x protein (Protocadherin 11 X-linked) (A0JNT1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MDLLSGTYIFAVLLACVVFQSGAQEKNYTVREEMPENVLIGDLLKDLNLSLIPDKSLTTPMQFKLVYKTGDVPLIRIEEGTGEIFTTGARIDREKLCAGIVLDARCFYEVEVAVLPDEIFRLVKIRFLIEDINDNAPLFPTTVINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADTNDNHPIFIEKEIEVSIPENAPIGSSVTQLHATDADIGENARIHFYFSNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTPARATVLVNVTDINDNVPSIDIRYIVNPTNGTVLLSENAPLNTKIALITVMDKDSEHNGRVTCFTDHEVPFRLRPVFSNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDENDNAPVFTQSFISLSVPENNSPGAQLTKISATDADSGQNAEISYMLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPPLMSNATVFVTVLDQNDNSPIFTHNEYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVSRSSTARVTINVVDVNDNKPIFIDPPSNYSFEWVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPDSLFNVVNVNFFINESVPNATLIYELVRRSIDAPANQNTETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVRCRQPPHLKASQKNKQNSEWVTPNPENRQMIMMKKKKKKKKKHPPKNLLLNFVTIEEAKPDDGENERNSVTLDLPIELEEQTMGKYNWGTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNSKHHIIQELPLDNTFVGCDSISKCSSSSSDPYSVSECSYPVTTFKAPVSVHIRPTMKEVVRSHTPMKEATTVEIWTHPHPQSQRRVTFHLPEGSQESISDGGLGDHDAGSLPSTSHALPLGYPQEEYFDHAAPNNRTEGDGNSDPESIPLHPSKTTASRSFHIHHTLLSN
Protein: Large ribosomal subunit protein bL28m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (Q9D1B9)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q13084}.
Interaction partners:
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL66
- Small ribosomal subunit protein mS26
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein uL3m
Sequence:
MPLHRYPVHLWQKLRLRQGICARLPAHFLRSLEEERTPTPVHYKPHGTKFKINPKNGQRERVEDVPIPVHYPPESQQGLWGGEGLILGYRYANNDKLSKRVKKVWKPQLFTRELYSEILDKKFTVTVTMRTLDLIDEAYGFDFYILKTPKEDLGSKFGMDLKRGMLLRLARQDPHLHPENPERRAAIYDKYRSFVIPEAEAEWVGLTLEEALEKQRLLEEKDPVPLFKVYVEELVQRLQEQVLSRPAVVQKRAGDHA
Protein: Transcription factor PU.1 (31 kDa-transforming protein) (SFFV proviral integration 1 protein) (P17433)
Organism: Mus musculus (Mouse)
Function: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition. Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box. In vitro can bind RNA and interfere with pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P17947}.
Interaction partners:
- Interferon regulatory factor 8
- Transcription factor Jun
- Interferon regulatory factor 4
- CCAAT/enhancer-binding protein alpha
- Erythroid transcription factor
- Runt-related transcription factor 1
- Macrophage colony-stimulating factor 1 receptor
- Endothelial transcription factor GATA-2
- Integrin alpha-M
- Retinoic acid receptor alpha
Sequence:
MLQACKMEGFSLTAPPSDDLVTYDSELYQRPMHDYYSFVGSDGESHSDHYWDFSAHHVHNNEFENFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHTGLSHQVSYMPRMCFPYQTLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH
Protein: Potassium channel tetramerisation domain containing 10, isoform CRA_a (Potassium channel tetramerization domain containing 10) (cDNA FLJ41739 fis, clone HSYRA2002590, highly similar to BTB/POZ domain-containing protein KCTD10) (B3KVY5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYEAQDGRGPDNALLEATGGAAGRSHHLDEDEERERIERVRRIHIKRPDDRAHLHQ
Protein: NADH-cytochrome b5 reductase-like protein (Q384X4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Dihydroorotate dehydrogenase
Sequence:
MDPSSGNGGGTSSSGFSTFSDSKYHEARRRKRQQLQQPQRWSYTLQDIPGIIRKAFNDVNTGYAARVAAFFGVTTGVSFSLYKFFFVRLQNDRPLAKRSRFAPHVPVTLLDKERIKGTDMFLFRFALPNSYDYCGYEPISSVQVTTGTVRSMTPVTRWFTPTSHPQQRGIIEFAVKERDPGRMAARLRSLQRGEQVYLGRWMREFPYQNNTYGELGLICTTSGASIALQLMNVMDKDKQDNTQLKFLYCHHTAKDIPFRSTFEAYAKRNPGRISVKYDVMSLGRPAADDGLHLGENVFLGHIDPTIVRKTLPPPVVTNGETGEPVRPKILICGPQRMLLPLCGRVNMLGNYTYWQGPFYKYCGFLKDMGYLRNQVYKFGVSTHLTAYQ
Protein: Centrosomal protein of 63 kDa-A (Cep63-A) (Xcep63) (B9V5F5)
Organism: Xenopus laevis (African clawed frog)
Function: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response: following DNA double strand breaks (DSBs), it is delocalized from centrosomes due to phosphorylation by atm and atr, leading to inactivate spindle assembly and delay mitotic progression.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q96MT8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P0CB05}.
Interaction partners:
Sequence:
MEALLQGLQRQDRMGALQDSCEAELQELMKQIDIMLDHKRSQWEAETETMKTRLELKEQELNCALDREERLNQEVRRLRQQLIQQEEETQNKTTQYEAQLSGFKEELNRLKKSYEKVQKKHLRSEMKAKAEEERSEVSRLTRRLEEFRQRSLDWEKQRLLYQQQLAGLEAQRKTLIEQTEMYQHQSHNRKQMLEQTSLVGRSELQNLSGQLHRANDSLCAKEEELETLKIQLRCAVEGQKRAEHETELSKQAVQALKEEKAELRATLQAHTEFLQGSRVQKHELLPEGYRGSEVLRENNSIRSVEERLQEMGQVGGETEVEAIRSKLSVSRMNEHRLQAEVTCLEDSVESVTSQCQLLAKELKGKEEYFHGVKEDHQKCLSENKKLKGQLSQAELTHKSVLDGMRKEISQLTQELHQRDIRMASSAGIDWERKIKAERQRAEREAAEHRMSLNALENLRQENCRLSELLQTQEPDVAQALVNLEQANQRLQRELLQTQEKLELIAQRRESEIQNAVDSISQELLNKQEQELRIMQERLKVYEQEMQTFRSQQDAASSGSSLESIFSEVWKEQATGSPISAASVDSAIEPVEDLASSLPVPPTSPANAVASRFLQEEEQRSHELLQRLNAHIEELKQESQRTVEHFTQAR
Protein: Protein ACTIVITY OF BC1 COMPLEX KINASE 1, chloroplastic (ABC1-LIKE KINASE 1) (EC 2.7.-.-) (EC 2.7.11.1) (Protein ABC1-LIKE KINASE RELATED TO CHLOROPHYLL DEGRADATION AND OXIDATIVE STRESS 1) (AtACDO1) (Protein BLEACHING AND DWARF IN RED LIGHT 1) (Protein PROTON GRADIENT REGULATION 6) (Q8RWG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Kinase that can phosphorylate the tocopherol cyclase VTE1, a key enzyme of tocopherol (vitamin E) metabolism and involved in the recycling of oxidated alpha-tocopherol quinone, possibly stabilizing it at plastoglobules. Regulates also plastoglobule protein composition. Prevents photodamage of chloroplasts under continuous red light, thus working in opposition to ABC1K3. Together with ABC1K1, contributes to plastoglobule (PG) function in prenyl-lipid metabolism, stress response, and thylakoid remodeling. Involved in chlorophyll degradation and in the maintenance of the number of chlorophyll-binding photosynthetic thylakoid membranes. Ensures photosynthetic electron transport by regulating the homeostasis of plastoquinone, beta-carotene and xanthophyll lutein, as well as membrane antioxidant tocopherol metabolism. Seems to affect specifically stability or turnover of D1 protein, product of psbA, one of the four core subunits of the photosystem II (PSII). Required for photooxidative stress responses, including the induction of oxidative stress response genes (e.g. FSD1, CSD1, CAT1, and UTG71C1), to prevent photosystem II core and chlorophyll degradations.
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16461379, ECO:0000269|PubMed:22274653}. Plastid, chloroplast {ECO:0000269|PubMed:22447966}.
Interaction partners:
- Tocopherol cyclase, chloroplastic
- Gb|AAD30234.1
- At1g79420/T8K14_16)
- Replication factor C subunit, putative
- DUF620 family protein
- Glutamyl-tRNA
- Rho GTPase-activating protein 3
- Lipase, putative
- Emb|CAB81597.1)
- Protein kinase superfamily protein
Sequence:
MESIHCNSLLNPNFSLNQRRRRINHAVLNRRDALLRSLNAVELRRSRTFSAVRTSNFSVTAAATDVGGRNSTDASVMTTAMSGVERGVRVGKSSSALEQLDIERGVCVPFRKYSPETVRSKVLESRGAVVSLVSRGVEIVWTLGLYWSTLTYDFLVGRDEEVVPFRARQLRNLLCNLGPSFIKAGQVLANRPDIIREDYMNELCILQDDVPPFPNEVAFNIIEEELGQPLENIFSKISSQTIAAASLGQVYRATLRATGEDVAIKVQRPQIEPIIYRDLFLFRTLASFLNGFSLQKLGCNAELIVDEFGEKLLEELDYTLEARNIEDFLENFKDDPTVKIPGVYKNLCGPRVLVMEWIDGIRCTDPQAIKDAGIDLNGFLTVGVSAALRQLLEFGLFHGDPHPGNIFAMQDGRIAYVDFGNVAVLSQQNKQILIDAVVHAVNEDYGEMANDFTRLGFLAKDTDVSPIVPALEAIWQNSAGKGLADFNFRSVTGQFNKLVYDFPIRIPERFSLVIRSLLTQEGICFTLKPDFKFLEVAYPYVAKRLLTDPNPALRERLIQVLFKDGVFQWKRLENLLSLAKENVAKMSSNPNLRVKRVESKLDLTDTIKDGARLFLLDEGIRRKLILALTEDSKLHVEELVDVYRLVEDEVDIPTLAMQVVQDLPNVFRDFVLSWSNSVLSDR
Protein: WD repeat-containing protein 37 (Q8CBE3)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y2I8}. Nucleus {ECO:0000250|UniProtKB:Q9Y2I8}. Note=Primarily localized in the cytoplasm with the highest concentration in the perinuclear region and in small clusters at the leading edge of the spreading cells. {ECO:0000250|UniProtKB:Q9Y2I8}.
Interaction partners:
- Phosphofurin acidic cluster sorting protein 1
- Armadillo repeat-containing protein 8
Sequence:
MPTESGSCSTARQAKQKRKSHSLSIRRTNSSEQERTGLPREMLEGQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDTLNERLAGEGQAIDGAELSKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAICQLVKEYIGHRDGIWDVSVTRTQPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYVVQLPTPQPVADTSQQISGEDEIECSDKDEPDIDGDVSSDCPTVRVPLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPICNLFTCGFDRQAIGWNINIPALLQEK
Protein: Scarecrow-like protein 1 (AtSCL1) (GRAS family protein 4) (AtGRAS-4) (Q9SDQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein PAT1 homolog
- At4g02725
- UDP-glycosyltransferase 79B9
- Probable non-intrinsic ABC protein 5
Sequence:
MVEQTVVREHIKARVMSLVRSAEPSSYRNPKLYTLNENGNNNGVSSAQIFDPDRSKNPCLTDDSYPSQSYEKYFLDSPTDEFVQHPIGSGASVSSFGSLDSFPYQSRPVLGCSMEFQLPLDSTSTSSTRLLGDYQAVSYSPSMDVVEEFDDEQMRSKIQELERALLGDEDDKMVGIDNLMEIDSEWSYQNESEQHQDSPKESSSADSNSHVSSKEVVSQATPKQILISCARALSEGKLEEALSMVNELRQIVSIQGDPSQRIAAYMVEGLAARMAASGKFIYRALKCKEPPSDERLAAMQVLFEVCPCFKFGFLAANGAILEAIKGEEEVHIIDFDINQGNQYMTLIRSIAELPGKRPRLRLTGIDDPESVQRSIGGLRIIGLRLEQLAEDNGVSFKFKAMPSKTSIVSPSTLGCKPGETLIVNFAFQLHHMPDESVTTVNQRDELLHMVKSLNPKLVTVVEQDVNTNTSPFFPRFIEAYEYYSAVFESLDMTLPRESQERMNVERQCLARDIVNIVACEGEERIERYEAAGKWRARMMMAGFNPKPMSAKVTNNIQNLIKQQYCNKYKLKEEMGELHFCWEEKSLIVASAWR
Protein: (RS)-norcoclaurine 6-O-methyltransferase (Ps6OMT) (EC 2.1.1.128) (Q6WUC1)
Organism: Papaver somniferum (Opium poppy)
Function: Involved in the biosynthesis of (S)-coclaurine, the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or papaverine. Catalyzes the transfer of a methyl group to norcoclaurine to form coclaurine. Methylates (R,S)-norcoclaurine, (R)-norprotosinomenine, (S)-norprotosinomenine and (R,S)-isoorientaline.
Interaction partners:
Sequence:
METVSKIDQQNQAKIWKQIYGFAESLVLKCAVQLEIAETLHNNVKPMSLSELASKLPVAQPVNEDRLFRIMRYLVHMELFKIDATTQKYSLAPPAKYLLRGWEKSMVDSILCINDKDFLAPWHHLGDGLTGNCDAFEKALGKSIWVYMSVNPEKNQLFNAAMACDTRLVTSALANECKSIFSDGISTLVDVGGGTGTAVKAISKAFPDIKCTIYDLPHVIADSPEIPNITKISGDMFKSIPSADAIFMKCILHDWNDDECIQILKRCKEALPKGGKVIIVDVVIDMDSTHPYAKIRLTLDLDMMLNTGGKERTKEEWKTLFDAAGFASHKVTQISAVQSVIEAYPY
Protein: Cell adhesion molecule CEACAM2 (Biliary glycoprotein 2) (BGP-2) (Carcinoembryonic antigen-related cell adhesion molecule 2) (CEA-related cell adhesion molecule 2) (Q925P2)
Organism: Mus musculus (Mouse)
Function: Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23070997}; Single-pass type I membrane protein {ECO:0000269|PubMed:23070997}. Note=Localizes to sites on the plasma membrane of elongating spermatids where Sertoli cells make contact.
Interaction partners:
- Cell adhesion molecule CEACAM1
- Transforming growth factor beta-1 proprotein
- Tyrosine-protein kinase SYK
- TGF-beta receptor type-2
- TGF-beta receptor type-1
- T-cell surface glycoprotein CD3 delta chain
- T-cell differentiation antigen CD6
- Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
- Tyrosine-protein kinase ZAP-70
- Tyrosine-protein phosphatase non-receptor type 6
Sequence:
MELASAHLHKGQVPWFGLLLTASLLASWSPPTTAQVTVMAFPLHAAEGNNVILVVYNMMKGVSAFSWHKGSTTSTNAEIVRFVTGTNKTIKGPVHSGRETLYSNGSLLIQRVTMKDTGVYTIEMTDQNYRRRVLTGQFHVHTLLLKSNITSNNSNPVEGDDSVSLTCDSYTDPDNITYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCETRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLINEKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPSLQVTNTTVKELDSVTLTCLSKDRQAHIHWIFNNDTLLITEKMTTSQAGLILKIDPIKREDAGEYQCEISNPVSVKRSNSIKLEVIFDSTYDISDVPIAVIITGAVAGVILIAGLAYRLCSRKSRWGSDQRDLTEHKPSASNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPRATETVYSEVKKK
Protein: RING finger protein 121 (E7EYE4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF185
- Ubiquitin-conjugating enzyme E2 G1
- NACHT, LRR and PYD domains-containing protein 16
Sequence:
MAGVFEVEVDGVEHDHGHGHHEDGKIDLSRLSPEEKWRLDHAKLHAKHKGHEAMHAEMVLILIVTLVVAQLALVQWKQRHQKSYNMVTLFQMWVIPLYFTSKLHWWRFMVVWFTFSIITAFVTFRATRKPLACTTPRLVYKWFLLFYKINYGTGIVGYAIVMLTLFGINLLFGIKPDDCMDLGVSLLFYGLYFGVLGRDFAEICADVMASTIGYYTESGMPTKHLSDSICAVCGQTTLVDANQEGIIENTYRLTCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFRNPWERPHMMYGQLLDWLRYLVAWQPIIIGLVQLINYILGLE
Protein: Myelin-associated glycoprotein (Myelin-associated glycoprotein isoform X2) (A0A0R4IQ16)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKGLELLLLPLLLLLKDASAQWNVWMPRDISAMTNSCVVIPCSFTYPSGIRPYRGVHGIWYFGHPYPQLFPPVVLKSRTDIVHESYKGRTKLLGDLTQKNCTLLISNIGVEHSGKYYFRADLGGANIYTFPDFTKLQVLDQPNIDVPEEIVSDQSLDLTCYVPDNCPDMSPEIHWMYTDYLPDPVFTPDQVEEGNTAVLSSTLTFTPKPMHNGQLLGCRVNFPNTTYVYERLITLDIRYAPRTVWVNVSQEVMEGSSVVLHCDVDSNPAPMITWYFGDKELMSETASNSSLSLENLTPEQEGVYTCVGDNGYGNMNTSMYLAVNYPPREPWINESLTVLEGSSVSLQCTSKGNPMPTLTWLKDGELVGTITAEEGSVLELHEIMPQADGVYRCLAENEHGRASSSLNITVEFAPVLLDDSKCTIVREGVQCVCIASGNPEPAIEFYLPDLNVTINNSNNRFNYYTHSDGYTSTGVIKLQDKGERGNNGDTAVHVHCSITNIYGSETIRLELQQEKKYMMAVIVGTIGGVAVIAFIIAAVRYVGQNNKKENGNPGQDVGSKVENPSMFYSAVKKDKQSLRKKVGDDSDYQSVGPMAGMERQELNYAALEFLHGRHREGVFRRADGDGSDYTEIKAK
Protein: Eukaryotic translation initiation factor 4E binding protein 2 (A0A8I6A0I3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSASAGGGHQPSQSRAIPTRTVAISDAAQLPQDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGALMEDSKVEVNNLNNLNNHDRKHAVGLCEAARAPDVD
Protein: LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (mLdb1) (Nuclear LIM interactor) (P70662)
Organism: Mus musculus (Mouse)
Function: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.
Subcellular location: Nucleus {ECO:0000269|PubMed:8876198, ECO:0000269|PubMed:9315627, ECO:0000269|PubMed:9391090}. Note=Colocalizes with SLK at leading edges (PubMed:19675209). {ECO:0000269|PubMed:19675209}.
Interaction partners:
- Rhombotin-2
- T-cell acute lymphocytic leukemia protein 1 homolog
- Erythroid transcription factor
- LIM/homeobox protein Lhx3
- Transcription factor E2-alpha
- Endothelial transcription factor GATA-2
- Insulin gene enhancer protein ISL-1
- Rhombotin-1
- LIM/homeobox protein Lhx2
- Single-stranded DNA-binding protein 2
Sequence:
MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
Protein: Forkhead box protein O3B (Forkhead protein FKHR) (Q9W7F8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MAETTLEPLSSLDIAIDPDFEPQKRPRSCTWPLPESSMAKPASNDTDIIPEEEDDEDDSAMTINANGMGEGEDNGSPSLAEELISINGQENTGSPLSSQAASATTASPEVASQQQTPRKSSSRRNAWGNLSYADLITKAIESTPDKRLTLSQIYDWMVSSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGRGGKAPRRRAVSMDNGNKYTKTARGRAAKKKAALQAAQEGSLENISAGGLSKWPGSPTSRSSDEQESCWTDFRSRTNSNASTVSGRLSPILANPELDDVSDGPPLSPILYSSPSSLSPPSSTSSNSKTCPGELPVLADLTGTMNLNEADNLMVDLLDNIATQVQVVQESSPFSFGSKSTASPPSTSTSQTVSNNTGGFSNPIFGPSPGSLRQKPMQTIQENKQTSFSSISCFETSLQDLLNSDSLVSHSHSDVMMTQSDPLISQASAAVTSQNYRLRNNPMLRNDPMMSSFSSVLNGRSGHLQNKQHHQGSNGQGSLRSLSNNRAQSLVNDANNLVSAKQLLQPQPTMLMTETPLYSGMNGSNGLGICHPSGTDRFPSDLDLDIFNGSLDCDVDSIIRSELMDSDGLDFNFDALMQNAVSLNPVGNFTGTKQSNHSWVPG
Protein: H6 family homeobox 4 (Q0P3T9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MRSESADSCDDAQQKNNGKKNKLMTKKKTRTIFSKRQIFQLESTFDMKRYLSSAERACLANSLQLTETQVKIWFQNRRNKLKRQLSTELEGPNSEFGDIGKTVPLPALYKENNLLGRCMLPMPLPVVYPGGSAPYFYFSNASKYFSLFDGDI