wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) (Q9BZE0)
Organism: Homo sapiens (Human)
Function: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).
Subcellular location: Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein CBFA2T3
- Killer cell immunoglobulin-like receptor 2DL4
- Nephrocystin-1
- BBSome complex member BBS1
- Natural cytotoxicity triggering receptor 3
Sequence:
MHSLDEPLDLKLSITKLRAAREKRERTLGVVRPRALHRELGLVDDSPTPGSPGSPPSGFLLNSKFPEKVEGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPERQGNGDLPPVPSASDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLTPPKDKCLSPDLPLPKQLVCRWAKCNQLFELLQDLVDHVNDYHVKPEKDAGYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPAPDGGPYVSGAQIIIPNPAALFGGPGLPGLPLPLAPGPLDLSALACGNGGGSGGGGGMGPGLPGPVLPLNLAKNPLLPSPFGAGGLGLPVVSLLAGAAGGKAEGEKGRGSVPTRALGMEGHKTPLERTESSCSRPSPDGLPLLPGTVLDLSTGVNSAASSPEALAPGWVVIPPGSVLLKPAVVN
Protein: Beclin-1 (F1RCP1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity). Involved in endocytosis including endosome formation in neuronal cells (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14457}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome {ECO:0000250|UniProtKB:Q14457}. Cytoplasmic vesicle, autophagosome {ECO:0000305}.
Interaction partners:
- UV radiation resistance-associated gene.
- Apoptosis regulator Bcl-2
- Beclin 1-associated autophagy-related key regulator
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphoinositide-3-kinase, regulatory subunit 4.
- Nuclear receptor binding factor 2
- Bcl-2-like protein 1
- Autophagy protein 5
- Activating molecule in BECN1-regulated autophagy protein 1A
- non-specific serine/threonine protein kinase
Sequence:
METLRFSSNTMQVSFVCQRCNQPLKLDTSFNVLDRMTIHELTAPLVMVTANKQQDSGESSSFPEETFLENKQDGVARKFIPPARMMSAESTNSFTLIGEASDGGTMENLSRRLKVTSNLFDIMSGQTDIDHPLCEECTDTLLDHLDTQLNITENECQNYKSCLELLSQLPEEEEASLLNALQQLKQEEESLIQELESIETKREAVAKELDEGRNHSQLMDTEELRYQKEYCEFKRQQLELDDDLKSVDNQMRYCQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALASKMGLCFQRYQLVPYGNHSYLESLSDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKDDTGFCLPYRMDVDKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNR
Protein: PflI (Polar flagellum linked protein) (Q9A6M7)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Magnesium transporter MgtE intracellular domain-containing protein
- Endoglucanase
Sequence:
MSVVALAMNGFLAVLLIAALIFGWRLERRLKALRDSHEGFAKAVADLDQAAARAEQGLADLRAATDEAAETLAVRIERAQALAAQLEDRVNRPAPPKAQAAPEREAPPRPSRAIEAPPVPPPGERRLSAADFERLLEREDRVERAARGEPAPRPAPRPNLSQETPRSRARVDDDLFDGPVDPPRPTSNPRVPRR
Protein: Cell division protein FtsZ (P47466)
Organism: Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00909}.
Interaction partners:
- Protein P200
- Ribosomal RNA small subunit methyltransferase H
- Transcriptional regulator MraZ
- Protein translocase subunit SecA
- Uncharacterized protein MG223
- Phenylalanine--tRNA ligase beta subunit
- Chromosome partition protein Smc
- ATP-dependent zinc metalloprotease FtsH
- Chaperonin GroEL
- Chaperone protein DnaK
Sequence:
MDENETQFNKLNQVKNKLKIGVFGIGGAGNNIVDASLYHYPNLASENIHFYAINSDLQHLAFKTNVKNKLLIQDHTNKGFGAGGDPAKGASLAISFQEQFNTLTDGYDFCILVAGFGKGTGTGATPVFSKILKTKKILNVAIVTYPSLNEGLTVRNKATKGLEILNKATDSYMLFCNEKCTNGIYQLANTEIVSAIKNLIELITIPLQQNIDFEDVRAFFQTKKTNQDQQLFTVTHPFSFSFDSKDSIEQFAKQFKNFEKVSYFDHSIVGAKKVLLKANINQKIVKLNFKQIQDIIWTKIDNYQLEIRLGVDFVTTIPNIQIFILSEHKNPVSLPIDNKSTENNQNKLKLLDELKELGMKYVKHQNQIY
Protein: Putative ion channel POLLUX-like 2 (Q940Y9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome P450, family 705, subfamily A, polypeptide 4
- Cytochrome P450 76C4
- Cytochrome P450
- Cytochrome P450, family 706, subfamily A, polypeptide 4
Sequence:
MMVAVQLFTWKPLVLLPSQSSRLDRFASFNRSLSLKSLPLGGIGSFRCPGTFKVKSQRTGDTEPSSSVNLNDFSSILHKSLPYKVVIGCIPLYAVFRIAQKICQELPRLVQNSVGAGLPFACASNSLPTPLKLDVSFPSFQDIRWGLARFLYLFNIQLEKNIGTFLVALMIACVSFVIIGGLLFFKFRKDLPLEDCLWEAWACLISSSTHLKQKTRIERVIGFVLAIWGILFYSRLLSTMTEQFRYNMTKLREGAQMQVLEADHIIICGINSHLPFILKQLNSYHEHAVRLGTATARKQRLLLMSDTPRKQMDKLAEAYSKDFNHIDILTKSCSLNLTKSFERAAASMARAIIILPTKGDRYEVDTDAFLSVLALQPIQKMESIPTIVEVSSPNTYDLLKSISGLKVEPVENVTSKLFVQCSRQKDLIKIYRHLLNYSKNVFNLCSFPNLVGTKYRQLRLGFQEVVVCGLLRDGKVNFHPNDNEELMETDKLLFIAPLNWKKKQLLYTDMKLENITVPTDTRKQVFEKKRSRLSKIIMRPRKSLSKGSDSVKGPTESILLLGWRGDVVQMIEEFDNYLGPGSSMEILSDVSLEDRRRVGDSIGSVKIKNIQVSHKVGNPLNYDTLKQTIMRMKSKYRKGKNIPLTILVISDRDWLLGDPSRADKQSAYSLLLAESICNKLGVKVHNLASEIVDSKLGKQITGLKPSLTFIAAEEVMSLVTAQVAENSELNEVWKDILDADGDEIYVKDVELYMKEGENPSFTELSERAWLRREVAIGYIKGGKKMINPVPKNEPLSLEMDDSLIVISELEGDQPITL
Protein: Ribonuclease 4 (RNase 4) (EC 3.1.27.-) (Q9JJH1)
Organism: Mus musculus (Mouse)
Function: This RNase has marked specificity towards the 3' side of uridine nucleotides.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P34096}. Note=Detected in urine. {ECO:0000250|UniProtKB:P34096}.
Interaction partners:
- Angiogenin-2
- Angiogenin ribonuclease 6
Sequence:
MMDLQRTQSLLLLLVLTLLGLGLVQPSYGQDRMYQRFLRQHVDPQATGGNDNYCNVMMQRRKMTSVQCKRFNTFIHEDIWNIRGICSTTNILCKNGQMNCHEGVVKVTDCRETGNSKAPNCRYRARTSTRRVVIACEGDPEVPVHFDR
Protein: 9-cis-epoxycarotenoid dioxygenase NCED2, chloroplastic (LeNCED2) (SlNCED2) (EC 1.13.11.51) (Nine-cis-epoxycarotenoid dioxygenase 2) (K4CJJ1)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid (ABA) biosynthesis from carotenoids.
Subcellular location: Plastid, chloroplast stroma {ECO:0000250|UniProtKB:Q9LRR7}. Note=Partially bound to the thylakoid. {ECO:0000250|UniProtKB:Q9LRR7}.
Interaction partners:
- Neoxanthin synthase, chloroplastic
- Xanthoxin dehydrogenase
- Uncharacterized protein
- Zeaxanthin epoxidase, chloroplastic
- indole-3-acetaldehyde oxidase
- indole-3-acetaldehyde oxidase
- Abscisic acid 8'-hydroxylase CYP707A1
- Abscisic acid 8'-hydroxylase CYP707A2
- Zeta-carotene desaturase
- Prolycopene isomerase, chloroplastic
Sequence:
MTSTIANYRVSHSFSPSTSYSLDFTLPSKSISMKNHTTTKTKIHSALLTLPKQNNTPKNQPQFQTSHWNFFQKAAAKALDIVESALVSRELQNPLPKTADPRVQIAGNFAPVPEQSVRHNLPVTGTIPDCINGVYVRNGANPLFEPVAGHHLFDGDGMVHAVTVENGSVSYSCRFTETERLVQERELGHPVFPKAIGELHGHSGIARLLLFYARGVFGLVDHSHGTGVANAGLVFFNNRLLAMSEDDVPYHVQVLPSGDLQTVGRYNFDDQLKSTMIAHPKIDPVSGELFALSYDVVQKPYLKSFKFSPDGEKSPDVEIPLDVPTMMHDFAITENYVVIPDQQVVFKLQEMIKGGSPVIYDKNKKSRFGILPKNAENSENIIWVESAETFCFHLWNAWEEPETDEVIVIGSCMTPPDSIFNECNENLKSVLSEIRLNLKTGESTRRQLLSPSDQVNLEAGMVNRNKLGRKTQFAYLAIAEPWPKVSGFAKVDLSTGEIKKHIYGDKRYGGEPLFLPRNVNSEKEDDGYILAFCHDEKTWKSELQIVNAMTLELEATVKLPSRVPYGFHGTFISSKDLQNQV
Protein: DUF724 domain-containing protein 1 (AtDUF1) (Q9ZVT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the polar growth of plant cells via transportation of RNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:19795213}.
Interaction partners:
- Protein trichome birefringence-like 3
- DUF4228 domain protein
- Protein trichome birefringence
- E3 ubiquitin-protein ligase RDUF2
- Putative F-box protein At4g22180
- KIB1-4 beta-propeller domain-containing protein
- Putative F-box protein At5g55150
- Uncharacterized protein At4g25920
- F3H9.15 protein
- F-box protein At2g16300
Sequence:
MAIFKDCEVEIFSEEDGFRNAWYRAILEETPTNPTSESKKLRFSYMTKSLNKEGSSSPPTVEQRFIRPVPPENLYNGVVFEEGTMVDADYKHRWRTGVVINKMENDSYLVLFDCPPDIIQFETKHLRAHLDWTGSEWVQPEVRELSKSMFSPGTLVEVSCVIDKVEVSWVTAMIVKEIEESGEKKFIVKVCNKHLSCRVDEAKPNMTVDSCCVRPRPPLFFVEEYDLRDCVEVFHGSSWRQGVVKGVHIEKQYTVTLEATKDKLVVKHSDLRPFKVWEDGVWHNGPQQKPVKESPSNAIKQKPMCSSSGARPMTPKMATKHARISFNPEENVEELSVAETVAATGKLEKMGIAEESVSCVTPLKQTEANAEGNKLEPMRNQNCLRNDSTQQMLPEEENSKDGSTKRKREEKHNSASSVMDEIDGTCNGSESEISNTGKSICNNDDVDDQPLSTELPYYQSLSVVNSFAADAEETPAKSARTISPFAKKLPFWKSYETDELYKSLPQSPHFSPLFKAKEDIREWSAVGMMVTFYCLLKEVKDLQLDDSSSKLSSLSSSLAELEKHGFNVTDPLSRISKVLPLQDKRAKKAEERKCLEKKIECEEIERKRFEEEFADFERIIIEKKRQALVAKEKKEAADKRIGEMKTCAETIDQEIKDEELEFQTTVSTPW
Protein: Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase) (P42682)
Organism: Mus musculus (Mouse)
Function: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (By similarity). Within the complex, phosphorylates both PARP1 and EEF1A1 (By similarity). Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells. {ECO:0000250}.
Interaction partners:
- Proto-oncogene vav
- Guanine nucleotide exchange factor VAV3
- Tyrosine-protein kinase ITK/TSK
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Guanine nucleotide exchange factor VAV2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit gamma
Sequence:
MILSSYSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELSEKHSQRQRPWFAKLMGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVLTEIAETW
Protein: Sterol O-acyltransferase 1 (Acyl-coenzyme A:cholesterol acyltransferase 1) (Cholesterol acyltransferase 1) (B1APM4)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQ
Protein: Tetratricopeptide repeat domain 4 (Q6IQE3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAAPTQGEDSDDGMDEFMEKFKTQKYHNAFNESNWEEEFEKVPMFMKTAPENIDPEKHPDLACIQHIIHDDDRTPEEKARSLKDEGNEYFKEKKYKKAVVSYTEGLKTSCVNPELNAVLYTNRAAAHFHLGNMRSALNDATAAKKLKPDHNKAIIRGAQCLLELRNYAGALQWCDEGLKLFPTDKKLQELRATADKQKREADRDARKAKVKAKKQQNEKEALLAAIKERGIKLLKTEKPPHRASDSEDEDRDEDTSRALADLQLDGISSQEATGARVYMDEQGVLHWPVMFLYPEHSQTDFFSAFSEDASFIDHLAVMFGEELPPWDIDQKYQPQNLQMFFEDPEKGNLYQVDLQESLLRVLQHQRCSVKAGTPSFIVLVSESPFSRQFLSGKKVQRLKLLK
Protein: Inactive heparanase-2 (Hpa2) (Q8WWQ2)
Organism: Homo sapiens (Human)
Function: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}.
Interaction partners:
- Syndecan-1
- Heparanase
- Iduronate 2-sulfatase
- Leucine-rich repeats and immunoglobulin-like domains protein 2
Sequence:
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTLILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR
Protein: Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) (Q9NVC3)
Organism: Homo sapiens (Human)
Function: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BWH0}. Note=In neurons, located in soma. {ECO:0000250|UniProtKB:Q8BWH0}.
Interaction partners:
Sequence:
MAQVSINNDYSEWDLSTDAGERARLLQSPCVDTAPKSEWEASPGGLDRGTTSTLGAIFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQASNERTYQEVVWAVCGKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGASGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYASFLSVVGTWYVTAIVIIKYIWPDKEMTPGNILTRPASWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYQGVPVEEDVGRERRRRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFIFVFPGLCLIQAKLSEMEEVKPASWWVLVSYGVLLVTLGAFIFGQTTANAIFVDLLA
Protein: Glutamate dehydrogenase 1, mitochondrial (OsGDH1) (EC 1.4.1.3) (Q852M0)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Ferredoxin-dependent glutamate synthase, chloroplastic
- Glutamate synthase 1, chloroplastic
- Glutamate synthase 2, chloroplastic
- glutamate synthase
- Delta-1-pyrroline-5-carboxylate synthase 1
- Delta-1-pyrroline-5-carboxylate synthase 2
- 3-methyl-2-oxobutanoate dehydrogenase
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase
Sequence:
MNALAATSRNFKQAAKLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASYVGFRVQHDNARGPMKGGIRYHHEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPGDLSISELERLTRVFTQKIHDLIGIHTDVPAPDMGTNSQTMAWILDEYSKFHGYSPAVVTGKPVDLGGSLGRDAATGRGVLFATEALLAEHGKGIAGQRFVIQGFGNVGSWAAQLISEAGGKVIAISDVTGAVKNSNGLDIAKLMKHSSENRGIKGFDGGDAIDPRSLLTEECDVLIPAALGGVINKDNANEIKAKYIIEAANHPTDPEADEILSKKGVLILPDILANSGGVTVSYFEWVQNIQGFMWDEEKVNNELKTYMTRGFRDVKEMCRSHHCDLRMGAFTLGVNRVARATVLRGWEA
Protein: Prefoldin subunit 2 (Genes involved in microtubule biogenesis protein 4) (Gim complex subunit 4) (GimC subunit 4) (P40005)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Prefoldin subunit 4
- Prefoldin subunit 3
- Prefoldin subunit 5
- Prefoldin subunit 6
- Prefoldin subunit 1
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Bud site selection protein 27
Sequence:
MEQRNNVFQAKYNEYKQILEELQTKIIELGHDKDEHTIVIKTLKDAEPTRKCYRMIGGALVESDVQTSLPILETKKENIEGTISKMKETLIQTAKEFEKWKKDNKIQVVKN
Protein: Meiotically up-regulated gene 132 protein (O13699)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MLSFGGSLLSHSDIASRNKFSIDYSQFKAFFPGNWKFSNSKDKKPVRSPTLDEPVGDVDIDIFDVSKFYPLKRLSSIPEKIRANYHEELQTTSYDLVRNPFTHGLFCVVFYHQNKSYLKMGVTDNFNAFEEDSRVYQYGVNHKLSCKNLLLAINYSPKTYTKIFDFLRNGRAPLQVLVHHCMLYNFYPEDFQDALWCAVQAHVMNQVRLGRATLLHARACYQKIGDIRMYLIDPHDLYFSPNSLKWLIICSKQFQALVHLEVKMDTLKIFRRRSKYFNLARSCVSGFELSWLIMMTSIGSNASAVPVHAYLASKRILYPSIIPEEIFFMRKFDSSLFKDIKNIHELLGFLGRLFMDLQDCEKFHHDYTEYHCYRIGKPLYQNYEEEALRKKSQGVKDADFIKPLVTNTRTAEKYKAFFEYKRNIVLKKQS
Protein: Protein YecM (P52007)
Organism: Escherichia coli (strain K12)
Interaction partners:
- PF03932 family protein CutC
- Outer membrane protein assembly factor BamC
- Lipopolysaccharide assembly protein A
Sequence:
MANWQSIDELQDIASDLPRFIHALDELSRRLGLNITPLTADHISLRCHQNATAERWRRGFEQCGELLSENMINGRPICLFKLHEPVQVAHWQFSIVELPWPGEKRYPHEGWEHIEIVLPGDPETLNARALALLSDEGLSLPGISVKTSSPKGEHERLPNPTLAVTDGKTTIKFHPWSIEEIVASEQSA
Protein: shikimate kinase (EC 2.7.1.71) (F4IIJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEAAITQRIQYPSWVDCRKVECKPQRGSLRYSQQVKVDRRFRGLSLARLQPERRNDQRRAVSPAVSCSDNNSSGALLETGSVYPFDEDILKRKAEEVKPYLNGRSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNGTSVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGGAVIRPINWKYMHKGISIWLDVPLEALAHRIAAVGTDSRPLLHDESGDAYSVAFKRLSAIWDERGEAYTNANARVSLENIAAKRGYKNVSDLTPTEIAIEAFEQVLSFLEKEETMEIPDGDL
Protein: Coiled-coil domain-containing protein 184 (Q52MB2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEDGLLEIMTKDGGDMPAPLEVSTVPAVGDVISGEYNGGMKELMEHLKAQLQALFEDVRAMRGALDEQASHIQVLSDDVCANQRAIVSMCQIMTTAPRQGGLGVVGGKGSFQSDPQEPETPSPGIGDSGLLGRDPEDEEEEEEEKEMPSPATPSSHCERPESPCAGLLGGDGPLVEPLDMPDITLLQLEGEASL
Protein: Malic enzyme (A0A1W2PQT3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKYLLIDHF
Protein: Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) (Q80ZF8)
Organism: Mus musculus (Mouse)
Function: Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O60242}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- E3 SUMO-protein ligase RanBP2
- Complement C1q-like protein 3
- C1q-related factor
- Dedicator of cytokinesis protein 1
- Engulfment and cell motility protein 1
Sequence:
MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLLRKNHSIMQLCSSKNAFVFLQYDKNFIQIRRVFPTDFPGLQKKVEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLVLLNNVVLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQWSACSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSHCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRMRTCQGAAVTGQQCEGTGEEVRRCSEQRCPAPYEICPEDYLISMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVASWEQPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLVSVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVVIPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNYTVVNSKVIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKSNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILAQQPREIVMESSGTPSVTLIVGSGLSCLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSMNELSNPCLKKENTELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVSTQPSMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLDQHLAPQEHMQNLPFEPRTAVKNFMASELDDNVGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKPPSEYQHYTTINVLDTEAKDTLELRPAEWEKCLNLPLDVQEGDFQTEV
Protein: PRELI domain containing protein 3A (Protein slowmo homolog 1) (Q96N28)
Organism: Homo sapiens (Human)
Function: In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- TP53-regulated inhibitor of apoptosis 1
- PRELI domain-containing protein 1, mitochondrial
Sequence:
MKIWSSEHVFGHPWDTVIQAAMRKYPNPMNPSVLGVDVLQRRVDGRGRLHSLRLLSTEWGLPSLVRAILGTSRTLTYIREHSVVDPVEKKMELCSTNITLTNLVSVNERLVYTPHPENPEMTVLTQEAIITVKGISLGSYLESLMANTISSNAKKGWAAIEWIIEHSESAVS