Protein: Protein SON (Negative regulatory element-binding protein) (NRE-binding protein) (Q9QX47)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:P18583}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2. {ECO:0000250|UniProtKB:P18583}.
Interaction partners:
- RNA-binding protein 39
- Protein PRRC2C
- Probable ATP-dependent RNA helicase DDX5
- RNA-binding protein 25
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Serine and arginine-rich splicing factor 11
- Splicing factor 3B subunit 1
Sequence:
MAADIEQVFRSFVVSKFREIQQELSSGRSEGQLNGETNPPIEGNQAGDTAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEASRKSRCVSVQTDPTDEVPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKLKSHHDGNLESDSFLKFDSEPSAAALEHPVRAFGLSEASETALVLEPPVVSMEVQESHVLETLKPATKAAELSVVSTSVISEQSEQPMPGMLEPSMTKILDSFTAAPVPMSTAALKSPEPVVTMSVEYQKSVLKSLETMPPETSKTTLVELPIAKVVEPSETLTIVSETPTEVHPEPSPSTMDFPESSTTDVQRLPEQPVEAPSEIADSSMTRPQESLELPKTTAVELQESTVASALELPGPPATSILELQGPPVTPVPELPGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPVPQLSQELPGPPAPSMGLEPPQEVPEPPVMAQELSGVPAVSAAIELTGQPAVTVAMELTEQPVTTTEFEQPVAMTTVEHPGHPEVTTATGLLGQPEAAMVLELPGQPVATTALELSGQPSVTGVPELSGLPSATRALELSGQSVATGALELPGQLMATGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAQESHMLASNTMETHMLASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLASSTMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLASGAMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMMGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRVSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTDRSMMSMAADSYTDSYTDSYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALSTEQSALTADNTWSTEVTLSTGESLSQPEPPVSQSEISEPMAVPANYSMSESETSMLASEAVMTVPEPAREPESSVTSAPVESAVVAEHEMVPERPMTYMVSETTMSVEPAVLTSEASVISETSETYDSMRPSGHAISEVTMSLLEPAVTISQPAENSLELPSMTVPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVVKTPAVAVPEPLVAAPEPPTMATPELCSLSVSEPPVAVSELPALADPEHAITAVSGVSSLEPSVPILEPAVSVLQPVMIVSEPSVPVQEPTVAVSEPAVIVSEHTQITSPEMAVESSPVIVDSSVMSSQIMKGMNLLGGDENLGPEVGMQETLLHPGEEPRDGGHLKSDLYENEYDRNADLTVNSHLIVKDAEHNTVCATTVGPVGEASEEKILPISETKEITELATCAAVSEADIGRSLSSQLALELDTVGTSKGFEFVTASALISESKYDVEVSVTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSTNFVCKDVEDSLPIKESAQAVAVALSPKESSEDTEVPLPNKEIVPESGYSASIDEINEADLVRPLLPKDMERLTSLRAGIEGPLLASEVERDKSAASPVVISIPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKAARARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSAVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEESKDDDNVFSSSLPSEPVDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRKGLVAVGERAQKRSGNFSAAMKDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRKHFLFRVLRNGSPYQPNCMFFLNRY