wanglab/gogpt-training-data huggingface dataset:
Protein: Histone H3.3 (Histone H3.2) (P59169)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000269|PubMed:17439305, ECO:0000269|PubMed:25086063}. Chromosome {ECO:0000269|PubMed:17439305}. Nucleus, nucleolus {ECO:0000269|PubMed:25086063}. Note=Localized at rDNA loci in the nucleolus. {ECO:0000269|PubMed:25086063}.
Interaction partners:
- Histone H4
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
- Protein TONSOKU
- Protein SAWADEE HOMEODOMAIN HOMOLOG 1
- Histone H2B.6
- Chromo domain-containing protein LHP1
- Lysine-specific demethylase ELF6
- Histone acetyltransferase GCN5
- DNA
- Chromatin remodeling protein EBS
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPTTGGVKKPHRYRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSHAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Actin-related protein 3 (Actin-like protein 3) (Q99JY9)
Organism: Mus musculus (Mouse)
Function: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61158}. Cell projection {ECO:0000250|UniProtKB:P61158}. Nucleus {ECO:0000250|UniProtKB:P61158}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). {ECO:0000250|UniProtKB:P61158}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 1B
- Actin nucleation-promoting factor WASL
- Src substrate cortactin
- Actin-related protein 2/3 complex subunit 1A
- Actin nucleation-promoting factor WAS
Sequence:
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
Protein: BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) (M0R3F4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTF
Protein: L-tyrosine degradation gene cluster protein hmgX (Pyomelanin biosynthesis cluster protein hmgX) (Q4WHU0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin. The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisic acid (HGA). The protein hmgX is crucial for this conversion and thus, probably functions as an accessory factor to mediate specific activity of hppD. The homogentisate 1,2-dioxygenase hmgA is then involved in the cleavage of the aromatic ring of HGA and its conversion to 4-maleylacetoacetate. When hmgA activity is lowered by the cell wall integrity (CWI) signaling pathway, HGA accumulates and leads to the production of pyomelanin through benzoquinone acetic acid after oxidation and polymerization. On the opposite, in non-stress conditions, both hppD and hmgA activities are balanced and HGA is degraded into 4-maleylacetoacetate. 4-maleylacetoacetate is further converted to 4-fumarylacetoacetate by the maleylacetoacetate isomerase maiA, which is degraded into fumarate and acetoacetate by the fumarylacetoacetase fahA (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22046314}.
Interaction partners:
Sequence:
MASGTTIQPSRPSLTSNDSAVLQALFDAESSPSSAVAIDPSLSPFPEYLHISASDHESLKARELSIIRSLQSDDVSMDTITSAIRDLDALITEHPTYPSAYVNRAQALRLHIEKTAEASTDPEEAIFTPGNTESASRLFSDLGQAISLCTPRSPADPVSTVQARILADSHTHRGYLLLKAARLKKNANGNEMVGGPDKLRDMGPDQLEEMASRDFFFGGRYGNKVAQQLAVQTNPYAKMCGAIVKEALRKEVEGVI
Protein: Myosin VIIA (A0A8I5ZWB0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDKRRKKRKEVRREEGREADRLEGWSRRLEGIMDGQWPLAQGSASAGAWYLILFGYKNTEALPSSYKGDYVWMDLKSGQEFDVPIGAMVKLCESGQIQVVDDEGNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSSEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILKLLAAILHMGNLQYEARTFENLDACEVLFSPSLATAASHLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSIGLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKGTDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQGFLEKNRDTLHGDIIQLVHSSRNKFVKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIKFQARCRAYLVRRAFRHRLWAVITVQAYARGMIARRLHRRLRVEYWRRLEAERMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLQQMERARHEPINHSDMVDKMFGFLGTSSGLPGQEGQAPSGFEDLERGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQLSEGQKKTSVKHKLVHLTLKKKSKLTEEVTKRLHDGESMVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLADSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLVPTYIPDREITPLKNLEKWAQLAIAAHKKGIYAQRRTDAQKVKQDVVNYARFKWPLLFSRFYEAYKFSGPPLPKSDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRGAKLMAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRTKPYTLEEFSYDYFRSPPKHTLSRVMVSKARGKDRLWSHTREPLKQALLKKIVGSEELSQEACMSFIAVLKYMGDYPSKRTRSVNELTDQIFEWAVKAEPLKDEAYVQILKQLTDNHIRYSEEKGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIASRLLLKSSEGFSLFVKIADKVISVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEILLIAINKYGISLIDPRTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRNSRSGR
Protein: Oxytocin receptor (OT-R) (P30559)
Organism: Homo sapiens (Human)
Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Oxytocin-neurophysin 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Vasopressin-neurophysin 2-copeptin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- D
Sequence:
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
Protein: leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (A0A6I8PRS0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q6AYJ0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGRRPQFSTTERVIKAVPFPPTRRLTLKEVFENGKPKMDVLKNHLVKEGRVEEDVALKIINDGAAILKQEKTMLEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKYSELVYEACMHTFDCLPLAALLNQQFLCVHGGMSPEITCLDDIRKLDRFAEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEMSLVEEEGATSVRKEVIRNKIRAIGKMARVFTVLREESENVLILKGLTPTGTLPLGVLSGGKQTIETAKLQAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAGKTHPHPSKRSDHGKKAL
Protein: Oxidation resistance protein 1 (H2L003)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MGSFGSVSSVPPGSAKIPAFQMDYTITETDTLERVAASHDCTVGELMKLNKMASRMVFPGQKILVPLANADDVFDPPSSASSLKSSGNQISGIENAEDGIRKGPGGAVPAHVRRGSFTKTQSAPIPRGSNDEADTDCLQRFLKIKVKQVTESDGTVSGTLLVTPNCLMFDPDVSHPLVKENGPDLYGMVANMDEIQSVSVYKEISGLTGDKAEKKRDIFDPDHLRTPEDSPKKQIKQNGEIEIAKNEEVAFEAGSVDSNHSPKFGSDIALPAISEETKDSPCEEAKGDLSRNRSATLGDEEIQLRARSRTSSQASSNDERPRSFSELDTPSEGKNIGRFSPNAARRSFGKLGRTLSARAKSIQGTVTSGAEKVVGTAVQGTKTVAHGVVTHTKSAADTLQSGIENGAKAAADVAGRVVDKGQSLMSESINGVTEIFSVPDFEQPAKSPLAMKREQSLAKLQDLRRQTAEARENSAKENHAGVFACATSSDEAPDLFAAVDEIMERNRIQSNDSTASQSPILPFYMAVRLTRNKKKKKSSTSSPSYDEDIAFGNKLKREFWFAVPRNQADNIYHFLLQWSPDKYGLDTTTSTTEEPSSVMSNDGQDKGFIVLGSNADESLGGEKSTPLFGSSLLNREWELVTVSEMCRRLSLDQELELPIPDGAATSQILDELMIRQVMDILPPRAEGYPWVNIYNSEKHGFSLATMYRKMAEFDEDLSPVLLIIRDTKEHVFGAVVSSAIRPNDHFFGTGDSCLLWRFTGEVPHTRELRQYNWTGDNQYFVNAAKDSLSIGAGSGRNGLWLDADLNHGSSQKCETFDNEPLCGDDQDFIIQFIEAYGFRM
Protein: ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3) (P0DTC6)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Function: Disrupts bidirectional nucleocytoplasmic transport by interacting with the host RAE1-NUP98 complex. Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (By similarity). Prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities. Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation. Might induce accumulation of host HNRNPA1.
Subcellular location: Host endoplasmic reticulum membrane {ECO:0000269|PubMed:33060197, ECO:0000269|PubMed:35187564}; Peripheral membrane protein {ECO:0000269|PubMed:35187564}. Host Golgi apparatus membrane {ECO:0000269|PubMed:33060197, ECO:0000269|PubMed:35187564}; Peripheral membrane protein {ECO:0000269|PubMed:35187564}. Note=Localizes to virus-induced vesicular structures called double membrane vesicles.
Interaction partners:
Sequence:
MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (F4K8T6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MNLEFCFLQAYSILRDFRRNDKLIDVFEFLPDLDRFVYINDDEASKELCCDNRISNRKYTLWNFLPKNLWEQFSRFMNQYFLLIACLQLWSLITPVNPASTWGPLIFIFAVSASKEAWDDYHRYLSDKKANEKEVWIVKQGIKKHIQAQDIQVGNIVWLRENDEVPCDLVLLGTSDPQGVCYVETAALDGETDLKTRVIPSACVGIDLELLHKMKGVIECPVPDKDIRRFDANMRLFPPFIDNDVCSLTIKNTLLQSCYLRNTEWACGVSVYTGNQTKLGMSRGIAEPKLTAMDAMIDKLTGAIFVFQIVVVLVLGIAGNVWKDTEARKQWYVQYPEEAPWYELLVIPLRFELLCSIMIPISIKVSLDLVKGLYAKFIEWDVEMIDQETGTASYAANTAISEDLGQVEYILTDKTGTLTDNKMIFRRCCIGGIFYGNENGDALKDAQLLNAITSGSTDVIRFLTVMAICNTVLPVQSKAGDIVYKAQSQDEDALVIAASKLHMVFVGKNANLLEIRFNGSVIRYEVLEILEFTSDRKRMSVVVKDCQNGKIILLSKGADEAILPYARAGQQTRTIGDAVEHYSQLGLRTLCLAWRELEENEYLEWSVKFKEASSLLVDREWRIAEVCQRLEHDLYILGVTAIEDRLQDGVPETIETLRKAGINFWMLTGDKQNTAIQIALSCNFISPEPKGQLLMIDGKTEEDVSRSLERVLLTMRITASEPKDVAFVIDGWALEIALKHHRKDFVELAILSRTAICCRVTPSQKAQLVEILKSCDYRTLAIGDGGNDVRMIQQADIGVGISGREGLQAARAADYSIGRFRFLKRLILVHGRYSYNRTAFLSQYSFYKSLLICFIQIFFSFISGVSGTSLFNSVSLMAYNVFYTSVPVLVSVIDKDLSEASVMQHPQILFYCQAGRLLNPSTFAGWFGRSLFHAIIVFVITIHAYAYEKSEMEELGMVALSGCIWLQAFVVAQETNSFTVLQHLSIWGNLVGFYAINFLFSAIPSSGMYTIMFRLCSQPSYWITMFLIVGAGMGPIFALKYFRYTYRPSKINILQQAERMGGPILTLGNIETQPRTIEKDLSPISITQPKNRSPVYEPLLSDSPNATRRSFGPGTPFEFFQSQSRLSSSSGYTRNCKDN
Protein: Uncharacterized protein (Q57X70)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSIHQTKVCSVNEPLSNPDDSALEYCVEAQSPVNRTTSTWEFRSKLFPHAFAAVLDTDLSESETTQRELAEWTRKRCRNYERQGDILRSQLGVLVSSGAANGKRSDADDGDDEAFLVGLGEWSLQESSSQYLNSAKKKKCHRQLRCKDSYESALLLERQWSERHAVSLKHSCMKGAHPTPAAQNFELGCAKDLCRDASSVEIHSITPAASVVAAEKTRSVTACEPPTEQERKKNRGVASEHEGTQNFAEHLVVQYFIPDGSEAESGKSSNDTRGGACGRGLYSMPLSVFRYHYPQLLLDFLLQHSVVMESS
Protein: Rifin (Q8I212)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYTNILLFPLKLNILVNTHKKPSISPHHIQTTRLLCECELYMSNYDNDPEMKSVMQQFHDCTTQRFQEYDERLQEKRQICKDKCDKEIQKIILKDKIEKELTEKFSSLHTDIQGDDIPTCICEKSLADKVEKGCLRCAQNLGGIVVPSSGVLGEIAAFAVNAWKTTEIAAATELAKQAGAAAGKIAGEAMGVKTIIRIFEKIFSIDKLKGTTLKSFFTTTRYNDVKTIASVIDTEMNTSCVLNSFGNHAICGLRTKLDLVAKPGQVMVIQKDAITRMITDVVHKAEITAEAAKTQVAASKTAAAIKTNIEAIEAATTPYYTPIIASIVAVVVIILIMVIIYLILRYRRKKKMKKKLQYIKLLEV
Protein: Uncharacterized protein PB1A10.13 (Q9HDX7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Localizes at the cell tip and barrier septum.
Interaction partners:
Sequence:
MSSSKIKELREGLMSSSKWSMAPGMMMQQNQPRPATTTPPISRGNEDADEGLNTARSFSSFQDLKGMSGDAKEQESATLVHLTKGRAHPRSRRPPRQISIDSAKKEETKNTGSTKAADTKSSVEATISPLKDTKSPSNASVFPIKPTESKTSTTKDSETAKEEDDASSSTTKAVEATTSKASSAHTDTLATSASNSDRGASTPEMVVKAEKREGSTSPIPYSSLSIAERIKQAQNTPFLESKVLPQNNETSDEENVDVKPAAGTVKNVMQAFLQPATPAKDTASKEPSKSSQQPVRTKPRIAQSPFLAQDAKENGGNVEVSSPLSFSASKSPAAVDSSTKTPTEQVNVVSKQAPTTSSTSVISPDPLQTAAPSANVNEVIASLESKVVTRRTGSGNNYRVGLRNVSGSERTKSLSKESPVEPEKPALPDATSSSTPTTENKESWTNQGIKSSQQRSANASPATSPSNQASIHASFTKESSTHSSPSFTLESLFSGAPRVVELTRFSQPSPACSRALLARWKEEYRTSIH
Protein: 14-3-3-like protein GF14 chi (General regulatory factor 1) (P42643)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes. Involved in the regulation of nutrient metabolism.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P48349}. Cytoplasm {ECO:0000250|UniProtKB:P48349}. Note=Translocates from the cytosol to the nucleus when phosphorylated. {ECO:0000250|UniProtKB:P48349}.
Interaction partners:
- Isocitrate dehydrogenase regulatory subunit 3, mitochondrial
- Malate dehydrogenase 1, cytoplasmic
- Dual specificity phosphatase Cdc25
- Malate dehydrogenase 2, cytoplasmic
Sequence:
MATPGASSARDEFVYMAKLAEQAERYEEMVEFMEKVAKAVDKDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVSLIRDYRSKIETELSDICDGILKLLDTILVPAAASGDSKVFYLKMKGDYHRYLAEFKSGQERKDAAEHTLTAYKAAQDIANSELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDVADDIKEAAPAAAKPADEQQS
Protein: Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) (Q3UM45)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of protein phosphatase 1.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- E3 ubiquitin-protein ligase PPP1R11
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Leucine-rich repeat protein 1
Sequence:
MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHGGGGIVANLSEQSLKDGVDRGAEDPEEEHELAVDMETINLDRDAEDVDLTHYRIGKIEGLEVLKKVKSLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEVLDISFNMLRNIEGIDKLTQLKKLFLVNNKINKIENISNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSVQSNRLAKIEGLQSLVNLRELYLSNNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATYVRF
Protein: Large ribosomal subunit protein uL13 (60S ribosomal protein L13a) (Q9VNE9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein uL1
- 40S ribosomal protein S15
- Large ribosomal subunit protein eL30
Sequence:
MTGLTNRTVVIDGRGHLLGRLASVVAKYLLQGGKVAVVRCEELNLSGHFYRNKIKFLAYLRKRCNVNPARGPFHFRAPSRIFYKAVRGMIPHKTKRGQAALARLRVFDGIPSPYDKRRRVVVPIAMRVLTLRSDRKYCQVGRLSHEVGWHYQDVIKSLERKRKAKLRVTLKHNRELKKLTVKARENIAKAAEPFNKIIKSYGYEV
Protein: Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (PP1bp175) (Protein phosphatase 1 regulatory subunit 9A) (p180) (O35867)
Organism: Rattus norvegicus (Rat)
Function: Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction.
Subcellular location: Cytoplasm, cytoskeleton. Synapse, synaptosome.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sequence:
MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKPDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPNENAAIIAKTRGKGRPSSPQKRMKPKEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSGHESGQNNRHSPKKEKAGEAEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSESPGAITPGKAENSNYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSRPSSNKQATDTEEPEKSEAVPVPEVAQKGTSLASLPSEERQLSTEAEDVTAQPDTPDSTDKDSPGEPSAESQAMPKSNTLSRPKEPLEDAEANVVGSEAEQPQRRDLTGGGDLTSPDASASSCGKEVPEDSNSFEGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEGDDSDENNYYQPDMEYSEIVGLPQEEEIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQYDADDDETGEYATDEEEDEVGPILPGGDMAIEVFELPENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQLQQNIEENKERMVKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIRRQEVERKKLEEVEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPTRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHTQSQSRAVHEWSVQQVSHWLVGLSLDQYVSEFSAQNISGEQLLQLDGNKLKALGMTSSQDRALVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKSEKMTSTTEQP
Protein: RRM domain-containing protein (Q8I7K5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSGARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEKRGNSNNAARSGGGGGGNRGGAERGIAPAQQPYDNNGGHRSGGGGGRSGGGGTSFNGAAFTESQLMDEVPKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLSGKGFAFLRLDTRAHAESAKEAIDGRIIHGRQVRVRFAVHGAAIRVKELSPTVSNEMLYHAFSHFGDVERAVHIVDEKGRPTGEGIVEFERKPNCNEAMAAIRDKVFLLTASPKPLICEVLEPRDEDDGLAERMIPRTPGLSKERELGPRFPTPNSFEYVYGMKWKELYVVEQKRRAQLDEELRESRRRLESDMELAYQDYQAQMLREGYLMFFLLFFWFRALFFFF
Protein: Fucolectin-4 (Q9I928)
Organism: Anguilla japonica (Japanese eel)
Function: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Subcellular location: Secreted {ECO:0000269|PubMed:10924498}.
Interaction partners:
Sequence:
MEVKTIMLLFQILAISTLKQGSAHVPDGYVEENVALRGRATQSAQLRGEHAALAHASNAIDGNRDSNYHHGSCTHTEGANPWWRVDLLQVYTIASVTITNRGDCCGERISGARILIGNSLENNGINNPQCSVIGSLATGETRTFHCPQPMIGRYVTVYLPKIESLQLCEVEVNALLPVN
Protein: BET1 homolog (rBET1) (Golgi vesicular membrane-trafficking protein p18) (Q62896)
Organism: Rattus norvegicus (Rat)
Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14742712}; Single-pass type IV membrane protein {ECO:0000269|PubMed:14742712}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:14742712}. Golgi apparatus membrane {ECO:0000269|PubMed:14742712}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.
Interaction partners:
- Golgi SNAP receptor complex member 2
- Vesicle-trafficking protein SEC22b
- Golgi SNAP receptor complex member 1
- Syntaxin-5
- Sec1 family domain-containing protein 1
- Synaptobrevin homolog YKT6
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 7
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Alpha-soluble NSF attachment protein
Sequence:
MRRAGLGDGAPPGGYGNYGYANSGYNACEEENDRLTESLRSKVTAIKSLSIEIGHEVKNQNKLLAEMDSQFDSTTGFLGKTMGRLKILSRGSQTKLLCYMMLFSLFVFFVIYWIIKLR
Protein: MYB47 (A0A178W4W9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRTTWFDVDGMKKGEWTAEEDQKLGAYINEHGVCDWRSLPKRAGLQRCGKSCRLRWLNYLKPGIRRGKFTPQEEEEIIQLHAVLGNRWAAMAKKMQNRTDNDIKNHWNSCLKKRLSRKGIDPMTHEPIIKHLTVNTTNADCGNSSTTTSPSTTESSPSSGSSRLLNKLAAGISSRQHSLDRIKYILSNSIIESSDQAKEEEEKEEEEEERDSMMGQKIDGSEGEDIQIWGEEEVRRLMEIDAMDMYEMTSYDAVMYESSHILDHLF