wanglab/gogpt-training-data huggingface dataset:
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (E6EK17)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}.
Interaction partners:
Sequence:
MATIDGRPAQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSDKKPRAGQILWIRGLTRLQTQISVPIRVVNAFRQGLDARYGDHTNTSLAEVLRKQTSLSKRLSETSSIEYADNIPDELTIPEIDVERLSSHSHTETAV
Protein: Senescence-specific cysteine protease SAG12 (EC 3.4.22.-) (Cysteine proteinase SAG12) (Protein SENESCENCE-ASSOCIATED GENE 12) (Q9FJ47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cysteine protease that may have a developmental senescence specific cell death function during apoptosis, heavy metal detoxification, and hypersensitive response.
Subcellular location: Vacuole {ECO:0000269|PubMed:15743448}. Note=Localized in senescence-associated vacuoles (SAVs) with intense proteolytic activity that develop in the peripheral cytoplasm of mesophyll and guard cells. {ECO:0000269|PubMed:15743448}.
Interaction partners:
- Senescence-associated protein 13
- NAC domain-containing protein 92
- Xyloglucan endotransglucosylase/hydrolase protein 24
- Bidirectional sugar transporter SWEET15
- UPF0235 protein At5g63440
- Probable LRR receptor-like serine/threonine-protein kinase At4g30520
- Protein S40-3
- Magnesium dechelatase SGR1, chloroplastic
- NAC transcription factor 29
- Pheophorbide a oxygenase, chloroplastic
Sequence:
MALKHMQIFLFVAIFSSFCFSITLSRPLDNELIMQKRHIEWMTKHGRVYADVKEENNRYVVFKNNVERIEHLNSIPAGRTFKLAVNQFADLTNDEFRSMYTGFKGVSALSSQSQTKMSPFRYQNVSSGALPVSVDWRKKGAVTPIKNQGSCGCCWAFSAVAAIEGATQIKKGKLISLSEQQLVDCDTNDFGCEGGLMDTAFEHIKATGGLTTESNYPYKGEDATCNSKKTNPKATSITGYEDVPVNDEQALMKAVAHQPVSVGIEGGGFDFQFYSSGVFTGECTTYLDHAVTAIGYGESTNGSKYWIIKNSWGTKWGESGYMRIQKDVKDKQGLCGLAMKASYPTI
Protein: Squamosa promoter-binding-like protein 2 (Q9S840)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- AT3g20370/MQC12_13
- At3g27200
- Large ribosomal subunit protein P2x
- Carbon catabolite repressor protein 4 homolog 4
Sequence:
MECNAKPPFQWELENLISFGTSTAEVPRKLKPMEWEIDGFDCTSLYSSSFAYAGSSGSDIAHAFSKSSKSTSISSSSAEVRTHNFTSETGESLPGEFAKGIDTSPSLELSFGSGDPVLGLKLGKRTYFEDFWEVENAKGLGLPVTLASSSVSPVKKSKSIPQRLQTPHCQVEGCNLDLSSAKDYHRKHRICENHSKFPKVVVSGVERRFCQQCSRFHCLSEFDEKKRSCRRRLSDHNARRRKPNPGRTYDGKPQVDFVWNRFALIHPRSEEKFIWPSSKHVPSRVLMPQPAKTEISDTEHNRFGLLDPKTKTARAELFSKEKVTISSHMGASQDLDGALSLLSNSTTWVSSSDQPRRFTLDHHPSSNLQPVAHRSAAQLNSVSGYWQPDPPAVEGPTALHRNGVGQFNENYFSLNQFYN
Protein: Protein Wnt-5a (XWnt-5a) (P31286)
Organism: Xenopus laevis (African clawed frog)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context (By similarity). Plays a role in normal embryonic development.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P41221}. Secreted {ECO:0000250|UniProtKB:P41221}.
Interaction partners:
Sequence:
MRKNLWTFQFGGEASGLVGSAMVSQHFVVLLMSLYCLTQSVVESSSWWSLGMNPVQMPEVYIIGAQPLCSQLSGLSQGQKKLCQLYQDHMQFIGDGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAISAAGVVNAVSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNLDYGYRFAKEFVDAREREKIHQKGSYESSRIMMNLHNNEAGRRAVSTLADVACKCHGVSGSCSLKTCWLQLADFRKVGDHLKEKYDSAGAMKLNTRGKLVQVNNKFNSPTMNDLVYIDPSPDYCVHNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEVVDQFACK
Protein: Calcium-binding protein G (Calcium-binding protein 7) (Q54QT8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSTCGDNSKIFQDIQNFIQDYDLNKDYSVTSSEIYQSFLKKMNGDSLKASQAAGVLCSTVDMDNDGKFSYYEISKYCADQAKKQIEQNAETAALADVEALLLRLDKDKDKKLNKTEFVKFFKEQGYNPYSDPDYVLKIIDLDKDGYVSASELQEWFKQKRLAYARGPIC
Protein: alanine transaminase (EC 2.6.1.2) (A0A0G2JV84)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGLYAMSCSPSFWARVNLGRFAMQRAAVLVRRGSCPRASGPWGRSHSSAAAEASAALKVRPERSPRDRILTLESMNPQVKAVEYAVRGPIVLKAGEIEMELQRGIKKPFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLNSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDGVPADPDNIYLTTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEDNCWALNVDELRRALRQAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVPGEESFEQFTREKESVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLHKVKDFHLKFLEKYS
Protein: Aquaporin-4 (V9PBN7)
Organism: Homo sapiens (Human)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell projection {ECO:0000256|ARBA:ARBA00004316}. Endosome membrane {ECO:0000256|ARBA:ARBA00004608}.
Interaction partners:
Sequence:
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV
Protein: Biotinidase (Biotinase) (EC 3.5.1.12) (Q8CIF4)
Organism: Mus musculus (Mouse)
Function: Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:P43251}.
Interaction partners:
- Biotin--protein ligase
- Alpha-aminoadipic semialdehyde synthase, mitochondrial
Sequence:
MSGARTAPALFFLGCSALALGVSSASQEHREAEYYVAAVYEHPSVLSPNPLELVSRQEALELMKQNLDVYEQQVMAAAQKGVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPKLVRWNPCLEPFRFNDTEVLQRLSCMAIKGGMFLVANLGTKQPCLSSDPGCPQDGRYQFNTNVVFSDNGTLVDRYRKHNLYFEAAFDTPANVDLITFDTPFAGKFGVFTCFDILFFDPAVRLLRDFEVKHIVYPTAWMNQLPLLAAIEIQKAFATAFGVNVLAANIHHPTLGMTGSGIHTPLKSFWYHDMDDPKGHLIIAQVATNPQGLTGTGNTTSEMDPSHRKFLKILSGDPYCEKDAQEVHCDEAAKWNVNVPPTFHSEMMYDNFTLVPVWGTEGHLQVCSNSLCCHLLYERPTLSKELYALGVFDGLHTVHGTYYIQTCALVKCGGLGFDTCGQEITEAEGLFDFHLWGNFSTLYIFPLFLTSGMTLDTPDQLGWENDHYFLRKRGLSSGLVTAALYGRLYERK
Protein: Probable transcriptional regulatory protein (O53238)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- 3-isopropylmalate dehydratase large subunit
- 3-isopropylmalate dehydratase small subunit
Sequence:
MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRLAAALEVHRLLGRGQDGHWRLGPAITELATHVDDPLLVACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGLRDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFSARALAEVCRRGWAQSVAEREPGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRWAADLLSAADALTRRL
Protein: Rad, Gem/Kir family member 2, isoform C (A0A0B4LFV4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Straightjacket, isoform C
- non-specific serine/threonine protein kinase
Sequence:
MAQQQRSWDEGAVGGGSYGHPHSSHHKVPARAASNPLPCKGATPKLPRQYHGGPTSSYNYGGYDTPRSPKITTTFAQDSCDDVSSSTPSSYYQTPPSGSIDDSASLLSGRTTARSPKSQCQFVFDAVSPSHGRKFEYYEPISPDDGALYYDPPSSPRRQGSKKLMRTKTPLDPVPQLTTTGVDESMAVAMAMGGAGGGGYAQGGPNKRQRDEWELPVISKIEARNLSAAAGSSSAGGSYYGLKRDSCVTDCTQLSMESGETGTQHTNSTMVTHTTTSFSFTEPEMEQEAGQPQLRRQRRHAINITSNPGYQVLHSSHSTLDRTCSDSVVSLRYRKSTSDLTQDAEHELSGCKPNKPKAHVEHKPRRRGSSKGGLAYLASRRSSRESMKSACSNASIVSNDDVGPLAFQSSNRGRQRRTSNFLELPVPDHVRPRVCSLPERPYNPRASDDLYRLRHFSISKGNVVNCGDSIISRRSRSNTSVNSTNSRASERSPFEGSCCGAGYANVDSLPATPDDSENLDPPPPARYRVVMLGDAGVGKTALVNQFMTSEYMHTYDASLVLDDEFGEKTVSVLLDDEESDMVFIDHPSVEMSVENSLSTYEPHGCVVVFSVVDRSSFRVAEEIINYLWQENYTKDKAVILVGNKADLARARLITSQEGKALAASRDAKFIETSSGIQHNVDELLVGILKQMRLKEKREKKATASKMKTSRTHISLHLAKELLQKICLSDISKSKSCENLHVL
Protein: Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) (P43252)
Organism: Mus musculus (Mouse)
Function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Prostacyclin synthase
Sequence:
MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDSREMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPLSRPASGRRDPPAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPLTGGDGCSVGMPSKSEAIAACSLC
Protein: Solute carrier family 25, member 27, isoform CRA_d (Uncoupling protein UCP-4, isoform c) (Q9EPH5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MPFPEEESLQPLTQRWPRTSKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAKLGDGAMESAPYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGDLTTYDTVKHYLVLNTALEDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRMVKTGRFCFFLCFLYISLTCTLQVFFILLSDVWPHERPIHLPFKNLYCRGFFFFQPFLRIMFPFLTD
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) (G1TRG8)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
- G protein subunit beta 1
- Adenosine receptor A1
- G protein subunit alpha i3
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 1
- D
- Apelin receptor
- Regulator of G-protein signaling 9
- G protein subunit beta 4
- Sphingosine-1-phosphate receptor 3
Sequence:
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADTSRNDDARQLFALSAAAEEQGVLPEDLSGVIRRLWADQGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSHLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Protein: Large ribosomal subunit protein uL15y (60S ribosomal protein L27a-2) (Q9LR33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL13x
- Large ribosomal subunit protein eL28y
- Large ribosomal subunit protein uL30x
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein eL18x
- Large ribosomal subunit protein eL32z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL3z
Sequence:
MATALKKNRKKRGHVSAGHGRIGKHRKHPGGRGNAGGMHHHRILFDKYHPGYFGKVGMRYFHKLRNKFFCPIVNLDKLWSLVPEDVKAKSSKDNVPLIDVTQHGFFKVLGKGHLPENKPFVVKAKLISKTAEKKIKEAGGAVVLTA
Protein: Probable 6-phosphogluconolactonase 1 (6PGL1) (EC 3.1.1.31) (Q9LMX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24008768}.
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- Gluconokinase
- Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic
- Inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 5, cytoplasmic
- Glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic
Sequence:
MALTWTHKDRGEIRVHENLEELSIDLVDYIAEISEASIKEHGAFCIVLSGGSLISFMGKLIEPPYDKIVDWAKWYVFWADERVVAKNHDDSNYKLAKDNLLSKVNVFPRHICSINDTVSAEEAATEYEFAIRQMVRSRTVAASDNSDSPRFDLILLGMGSDGHVASLFPNHPALEVKDDWVTFLTDSHKPPPERITFTLPVINSAANVVVVATGESKANAIHLAIDDLPLPDSSLSLPARLVHPSNGNLIWFMDKQAGSKLDRFKFSE
Protein: Copper transporter 1 (AtCOPT1) (Q39065)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Copper transporter involved in copper acquisition and transport in leaves. Required for copper homeostasis and normal plant growth and development.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Squamosa promoter-binding-like protein 7
- Probable copper-transporting ATPase HMA5
- Ferric reduction oxidase 4
- Metal transporter Nramp3
- Ferric reduction oxidase 5
- Zinc transporter 2
- Metal-nicotianamine transporter YSL2
- Metal-nicotianamine transporter YSL3
- Zinc transporter 11
- Metal transporter Nramp4
Sequence:
MDHDHMHGMPRPSSSSSSSPSSMMNNGSMNEGGGHHHMKMMMHMTFFWGKNTEVLFSGWPGTSSGMYALCLIFVFFLAVLTEWLAHSSLLRGSTGDSANRAAGLIQTAVYTLRIGLAYLVMLAVMSFNAGVFLVALAGHAVGFMLFGSQTFRNTSDDRKTNYVPPSGCAC
Protein: Thioredoxin like 1 (K7ER96)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVSLLK
Protein: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) (P24140)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P23338}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H3H5}.
Interaction partners:
Sequence:
MWAFPELPLPLLVNLFGSLLGFVATVTLIPAFRSHFIAARLCGQDLNKLSRQQIPESQGVICGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDYRDDHVFSLYFMIPFFFTTLGLLYHNWYPSQVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFIPQVFNFLYSLPQLLHAIPCPRHRIPRLNPKTGKLEMSYSKFKTKNLSFLGTFILKVAERLQLVTVHRGESEDGAFTECNNMTLINLLLKIFGPIHERNLTLLLLLLQILSSAVTFSIRYQLVRLFYDV
Protein: Monocarboxylate transporter 8 (MCT 8) (Solute carrier family 16 member 2) (Q8K1P8)
Organism: Rattus norvegicus (Rat)
Function: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormone across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12871948, ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000255}. Note=Detected at the luminal and abluminal membrane surfaces of microvessels. {ECO:0000269|PubMed:18687783}.
Interaction partners:
- Solute carrier organic anion transporter family member 1C1
- Monocarboxylate transporter 10
- Solute carrier organic anion transporter family member 4A1
- Sodium/iodide cotransporter
- Thyroid hormone receptor alpha
- Thyrotropin receptor
Sequence:
MALPSPASEEAEGPCQEANQEYQEPVCSPVPEPEPEPEPEPEPEPEPVPVPPPEPQPEPEPQPLPDPAPLPVLGFEAEPVQEPEPTPTVETRGTARGFQPPEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDRIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGNYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRESSKDKMLSHDPDPNGELLPGSPTPEEPI
Protein: Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog) (Q3V0J1)
Organism: Mus musculus (Mouse)
Function: Component of the transition zone in primary cilia. Required for ciliogenesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:22152675}. Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone.
Interaction partners:
- Transmembrane protein 231
- Transmembrane protein 17
- Nephrocystin-1
- Meckelin
- B9 domain-containing protein 1
- Coiled-coil and C2 domain-containing protein 2A
- Nephrocystin-4
- Protein fantom
- Transmembrane protein 107
- Tectonic-1
Sequence:
MRDDSGPPLEEDQARPPRALPPVPSAIQVCSSFVENNSRMDQQDDLVGEDDIPLSHPKKKKSRTKSSLATASSEGHAEPVVNRRAEGSEPPAAELKEHPEAPAPRRQKKIRPPPELETSLTERPSSPSLLRNENGIDAEPREEAVIPKPRRKAKKTQPAEPQYASELGVEDEDILTDEQSTLEHHSRFTAPTGVSQPVGKVFVEKSRRFQAADRSELIKTTENIDVSMDVKPSWTTRDVALSVHRAFRMVGLFSHGFLAGCAVWNTVVIYVLAGDQLSNVSNLLQQYKPLAYPFQSLLYLLLALSTVSAFDRTDFAKISVAIRNFLALEPTALASFLYFTALILSLSQQMTSDRIHLYEPSVNGSLWAAEAEEPILVPWIIVNLVVALLVGLSWLFLSYRPGMDLSEELMFFSDVDEHPETGTKASP
Protein: Monothiol glutaredoxin-S15, mitochondrial (AtGrxS15) (Q8LBK6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides. Participates probably to the maturation of iron-sulfur proteins and to the regulation of the redox state of the BOLA proteins.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12954611}.
Interaction partners:
- Protein BOLA4, chloroplastic/mitochondrial
- Anamorsin homolog
- Protein BOLA1
- Protein BOLA2
- SufE-like protein 1, chloroplastic/mitochondrial
- NifU-like protein 5, mitochondrial
- NifU-like protein 4, mitochondrial
- Iron-sulfur cluster assembly protein 1
- Glutaredoxin-C1
- Adrenodoxin-like protein 1, mitochondrial
Sequence:
MAASLSSRLIKGIANLKAVRSSRLTSASVYQNGMMRFSSTVPSDSDTHDDFKPTQKVPPDSTDSLKDIVENDVKDNPVMIYMKGVPESPQCGFSSLAVRVLQQYNVPISSRNILEDQELKNAVKSFSHWPTFPQIFIKGEFIGGSDIILNMHKEGELEQKLKDVSGNQD
Protein: Cytochrome c oxidase assembly protein COX19 (Q387T5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MANGVTANSMRVSVKAPDLGAFPLDHYRECKSEIEEYYTCLRSNDYVTPMCREQVRAYLQCRMDRGLMKPADIEGFGIPETEFVPMRQHRADIRQQWLRQKMNQVTAVWESYRRDDLNVPDGYERPRGSDSGGRPQPLPGETNKT
Protein: Xanthoxin dehydrogenase (EC 1.1.1.288) (Protein ABSCISIC ACID DEFICIENT 2) (Protein GLUCOSE INSENSITIVE 1) (Protein IMPAIRED SUCROSE INDUCTION 4) (Protein SALOBRENO 3) (Protein SALT RESISTANT 1) (Protein SUGAR INSENSITIVE 4) (Short-chain alcohol dehydrogenase ABA2) (Short-chain dehydrogenase reductase 1) (AtSDR1) (Xanthoxin oxidase) (Q9C826)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of abscisic acid. Catalyzes the conversion of xanthoxin to abscisic aldehyde.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12417697}.
Interaction partners:
- Abscisic-aldehyde oxidase
- 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic
- 9-cis-epoxycarotenoid dioxygenase NCED6, chloroplastic
- 9-cis-epoxycarotenoid dioxygenase NCED9, chloroplastic
- Probable carotenoid cleavage dioxygenase 4, chloroplastic
- Probable 9-cis-epoxycarotenoid dioxygenase NCED5, chloroplastic
- 9-cis-epoxycarotenoid dioxygenase NCED2, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Molybdenum cofactor sulfurase
- Ethylene-responsive transcription factor ABI4
Sequence:
MSTNTESSSYSSLPSQRLLGKVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSLLRGESKETAFFIHGDVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNVKGAFLSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIRVNCVSPYAVATKLALAHLPEEERTEDAFVGFRNFAAANANLKGVELTVDDVANAVLFLASDDSRYISGDNLMIDGGFTCTNHSFKVFR
Protein: Peptidoglycan-recognition protein LB (EC 3.5.1.28) (Q8INK6)
Organism: Drosophila melanogaster (Fruit fly)
Function: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
Subcellular location: [Isoform C]: Secreted {ECO:0000305}.
Interaction partners:
- Nuclear factor NF-kappa-B p110 subunit
- Protein immune deficiency
- Poor Imd response upon knock-in, isoform A
- Diptericin B
- Diptericin A
- Peptidoglycan-recognition protein LD
- Cecropin-B
- Attacin-D
- Cecropin-C
- Defensin
Sequence:
MTALGLVLLSMMGYSQHMQQANLGDGVATARLLSRSDWGARLPKSVEHFQGPAPYVIIHHSYMPAVCYSTPDCMKSMRDMQDFHQLERGWNDIGYSFGIGGDGMIYTGRGFNVIGAHAPKYNDKSVGIVLIGDWRTELPPKQMLDAAKNLIAFGVFKGYIDPAYKLLGHRQVRDTECPGGRLFAEISSWPHFTHINDTEGVSSTTAPVVPHVHPQAAAPQKPHQSPPAAPKV
Protein: Serine/arginine repetitive matrix 2 (A0A087X1W1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEVCS
Protein: Target of rapamycin complex 2 subunit MAPKAP1 (Stress-activated map kinase-interacting protein 1) (E7EZP2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Early endosome membrane {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004220}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004633}. Lysosome membrane {ECO:0000256|ARBA:ARBA00023765}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00023765}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004450}.
Interaction partners:
- Serine/threonine-protein kinase TOR
- Target of rapamycin complex subunit lst8
- RPTOR-independent companion of MTOR, complex 2b.
- RPTOR-independent companion of MTOR, complex 2 a.
- AKT1 substrate 1
- Serine/threonine-protein kinase SMG1
- DNA-dependent protein kinase catalytic subunit
- Proline-rich 5a
- Regulatory-associated protein of mTOR
- DEP domain-containing MTOR-interacting protein.
Sequence:
MAFLDNPAIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKCHLSAASAGGGSSGGSYGDSSGGGVDGQTCDLSQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERSSSQSADDLSSLFEKKDFKDRPRSTGSKSTLSLRLEQCPQQLNNPFNEYSKFDGKGHVGTTATKKIDVYLSMQSTQEKLHPMTVVTMANARVHDLIGLICWQYTCEGREPKLTENVNTYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLGPKQSLFVRINAAHGFSLIPVDSLKVTMKDILQKALKKRKGSQKGSGPLYRLEKQMEPNVAVDLDSSLENQGTLEFCLVRENSSRGEESSEEDPPIDITTVQDMLSSHHYKSFKISMIHKLRFTTDVQLGISGEKVEIDPVTNQKTSTKFWIRQKPISIDSDLLCACDLVEEKSPNHAIFKLTYLSNHDYKALYFECDAATVNEIVLKVNYILESRASTSRADYFAQKQRKLSRRTSFSFQKDKKSGQ