wanglab/gogpt-training-data huggingface dataset:
Protein: Syndecan 4-A (Syndecan-4.1) (xSyn4.1) (Q1AGV7)
Organism: Xenopus laevis (African clawed frog)
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates non-canonical Wnt signaling, being necessary and sufficient for fibronectrin-mediated translocation of dvl2/dsh to the plasma membrane. Required for proper convergent extension movements during gastrulation, which shape the neural plate, and for subsequent neural tube closure.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSPTLMFVLLLCGVAAESIRETETMDPTSMLEYESSGSFPDEVFDDDEIDEDDDYAIDEDDEDYSGSGTDKFDIDDNDEDEEEEETATLGNQIPELDFDQTKTGRKIETNEIDNEIWSPTKPKILEPSNEISMASTGSEGFFQRTEVIVAIVAGTLVGLVVAISFIVFLVIRRNQNGDLVKKPIYKKTSTMEV
Protein: Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12) (Q3J125)
Organism: Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides)
Subcellular location: Cell inner membrane {ECO:0000256|RuleBase:RU365020}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Cyclic di-GMP-binding protein
- Cellulose synthase-like protein
- Beta-mannanase
- UTP--glucose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Trehalose-6-phosphate synthase
- Glucose-1-phosphate cytidylyltransferase
- Glucose-1-phosphate adenylyltransferase
- ADP-glucose pyrophosphorylase
- Lipoprotein
Sequence:
MTVRAKARSPLRVVPVLLFLLWVALLVPFGLLAAAPVAPSAQGLIALSAVVLVALLKPFADKMVPRFLLLSAASMLVMRYWFWRLFETLPPPALDASFLFALLLFAVETFSISIFFLNGFLSADPTDRPFPRPLQPEELPTVDILVPSYNEPADMLSVTLAAAKNMIYPARLRTVVLCDDGGTDQRCMSPDPELAQKAQERRRELQQLCRELGVVYSTRERNEHAKAGNMSAALERLKGELVVVFDADHVPSRDFLARTVGYFVEDPDLFLVQTPHFFINPDPIQRNLALGDRCPPENEMFYGKIHRGLDRWGGAFFCGSAAVLRRRALDEAGGFAGETITEDAETALEIHSRGWKSLYIDRAMIAGLQPETFASFIQQRGRWATGMMQMLLLKNPLFRRGLGIAQRLCYLNSMSFWFFPLVRMMFLVAPLIYLFFGIEIFVATFEEVLAYMPGYLAVSFLVQNALFARQRWPLVSEVYEVAQAPYLARAIVTTLLRPRSARFAVTAKDETLSENYISPIYRPLLFTFLLCLSGVLATLVRWVAFPGDRSVLLVVGGWAVLNVLLVGFALRAVAEKQQRRAAPRVQMEVPAEAQIPAFGNRSLTATVLDASTSGVRLLVRLPGVGDPHPALEAGGLIQFQPKFPDAPQLERMVRGRIRSARREGGTVMVGVIFEAGQPIAVRETVAYLIFGESAHWRTMREATMRPIGLLHGMARILWMAAASLPKTARDFMDEPARRRRRHEEPKEKQAHLLAFGTDFSTEPDWAGELLDPTAQVSARPNTVAWGSN
Protein: Gustatory and pheromone receptor 39a, isoform C (P58957)
Organism: Drosophila melanogaster (Fruit fly)
Function: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Gustatory and pheromone receptor 33a
- Gustatory receptor 23a
- Putative gustatory receptor 89a
- Gustatory receptor for bitter taste 93a
- Gustatory receptor for bitter taste 66a
- Putative gustatory receptor 28b
- Putative gustatory receptor 28a
- Putative gustatory receptor 9a
Sequence:
MDFQPGELCAYYRLCRYLGIFCIDYNPTKKKFRLRRSVLCYIVHFALQAYLVGCISVMVTYWRRCFKSELTTTGNHFDRLVMVIALGILVVQNAWLIWLQAPHLRIVRQIEFYRRNHLANVRLLLPKRLLWLIIATNVVYMANFIKTCIFEWLTDASRLFVITSLGFPLRYLVTSFTMGTYFCMVHIVRLVLDWNQSQINAIIDESADLKMTSPNRLRLRVCLEMHDRLMLLCNDEISLVYGFIAWLSWMFASLDVTGVIYLTMVIQTKKSIVLKLITNVVWLSPTFMTCAASFMSNRVTIQANKTAKMLTKVPRTGTGLDRMIEKFLLKNLRQKPILTAYGFFALDKSTLFKLFTAIFTYMVILVQFKEMENSTKSINKF
Protein: Zinc carboxypeptidase, putative (Q389Q3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Katanin p60 ATPase-containing subunit A-like 2
- CFA20 domain-containing protein
Sequence:
MARVCKREKKEVKCGEGCGRGRSSTGALLEPCKANGTMATSCSRRSPVRGGSKAAMSKHSTKHVAKSNGDVGQQPTLRDPFPPVLWIAPVKMMYSPGQITAAGLDNGRSVAAAVRSVSSRGNSVVSMYLRQMRVACTSFSGKLLSESGNVAASSFGGGFGSLSVTAGLSLYSHIYELHQWFFSGGALHSNGRPRVVKNGWQALCNKKNSSWRILMDVLDSELVLSDENAACSALTLVFNLLRSLPSRRRKRVVRLCARLQLPRLCDSILKVYDPAFTDALKVRWDNPRKDSRNLADDDYCDSESGGQEVQNLVFHTIPLRSLGPVRVYEAVALLMGLCGTVSGKVLSAVRRLRLLSLLLRASRQLFATIQKMLTNMDISGEDSIASHSVTSLPSVNYHQRMAAVGCVKNISDALLHMFVAFYQLSACSSIAESMCLQGVTLSIQVGRMVQSHLVQSPASQRTVHTPLDRCIEALGLWSVELLSRLCCNMKRSKRGLEVARQQRVVDLLIAFSTLHAENGDLMLSALDVLHVVTEMDAGCNEQLHDESGALSSLVSGAVAASEAMKHPATHWHKLFLAFYKLFGIVTLPGELSVLQCVEQVSSTVRVVPTLPLLPQHQRKARGEQEDSLSHIHLPPGAKVATEVHAPPLVDAEPSFFSPELRVDRCARGYMSLLPPANASAMAGAAHIPSTFTAPNGLPWDFFDEGIPLCQEFVSSDRPAADHPVLSSDYSLSLDEQPKLLLQPSLETRVRVMKRLIGRLSMCPRFSDCVVYERPPLTVASQPQDVFNMCDREAKRLESSLRFPPPLPSGDFKGVLKFRSNFESGNLQRAIAVDDMEYDLVLSPDTNTNCHVQWFCFSVEDYAPGATYHFNILNMEKSSSTFNEGQQPLMLFFESSGSMGAASQAPQWKHCGHDIFYYRNSYQRPARSTTTPAVDNSPAPSVEEGEGPKNSNKQQSSDRPKKKKATNKKRSSQRKEEPSHCYTLSFSIQFPERKGCVFIANCYPYTYSNLLSDVERWKLQASAVFGPSLLFAVQELCCTPGGLPVPILTLTASDIRGNVGVEDDSSAIHTEVAETPRERKLGSSNMDPEEFRPIKERPVLLVTARVHPGESNSSWVLRGLMSFLLSNRDNSHALRNRYVWKVIPMLNPDGVVLGNHRCSIGGADLNRDYANPNPATNPVVYSLKQIARHIIEKEQRRVPLFVDLHGHSRSKNFLMYGCMRSVATSKKRPAVKLPASIPGTVGSAYSIPSSNNRKQSLNSTASPAADSVTPEKLLPILLSQLSAAFSLPQCSFAVQKSKRHTGRVVMYRQFGIRMSYTLEATMMGGLDDAIEGLPGCNMRGLMKPGDYHDQRQQSKANAFEGVSGTTLREVSYGTRHFENMGARLARGVGLLSTNFSDSSSGYRALVERAWLILATAGSSDGIQTHIIANFGGSYALATRKERRTDQKGMNREKSCSFNVSLAELRAEVLRTLSLQPRLGDAPPAVSGSTLHGVISDDESSNDDDDDDDDDDDDQVVAGDVGEDCESSASGDNDDEDDDEDDDDDYDDDDDDFDELDVEDNASEDGDGDVLY
Protein: DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) (Q8IXB1)
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:23769672}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Hypoxia up-regulated protein 1
- Protein sel-1 homolog 1
- Endoplasmin
- Calreticulin
- Protein OS-9
- Calnexin
- Heat shock 70 kDa protein 4
- FAD-dependent oxidoreductase domain-containing protein 2
Sequence:
MGVWLNKDDYIRDLKRIILCFLIVYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWNYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKNSILFLNSLDAKEIYLEVIHNLPDFELLSANTLEDRLAHHRWLLFFHFGKNENSNDPELKKLKTLLKNDHIQVGRFDCSSAPDICSNLYVFQPSLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANDKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFIEDLMNPSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQGKRNKDEL
Protein: 60 kDa chaperonin (Q8I0V3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock protein 70
- 20 kDa chaperonin
- 10 kDa chaperonin
- Heat shock protein 60
- T-complex protein 1 subunit theta
- Endoplasmic reticulum chaperone GRP170
- GrpE protein homolog
- indole-3-glycerol-phosphate synthase
Sequence:
MRMKRIHILLLVIFLLCLRYGYSIKKKRSPNNKNRLFINKRLKYINSKIISRRKENYVKMKMTENKVKGKDIIYGNECRNELLKGILTVSDVVKLTLGPRGRNVLLEKEYGSPLIINDGVTIAKNISLKDRKKNNGVKLMQESTNISNDKAGDGTSSTALMTATITKKGIEQVNRNHNPIPIQRGIQLASKMIIEKIKSLSTPIKTYKDILNIATIASNNDVHMGQIIANAYDKLGKNAAIILDDNADINDKLEFTEGYNFDRGIINPYLLYNENKDYIEYSNVSTLITDQNIDNIQSILPILEIFAKNKQPLCIIADDFSNEVLQTLIINKLKGAIKVVPIRAPSFGDRRKDYLKDLCIVTNSKYISADVGLDLNNLHNNMSSFDNNYLSLLGSANTLIVKKDRTSLITKEEYKKEIDERINVLKKEYEETTSKYDKEKLNERIAALSGGIAKILIGGNSETEQKERKFKYEDATNAVKSAIDIGYVPGGGVTYLEIIKSNFIQEIHKKIEEDLQISSNNDEKKYLELIGNLESEMELQKMGANIVVSSLDVITKQIADNAGVNGDNVVKIILNSKDKYGFGYDVNTNKFVNMVEKGIIDSTNVIISVIKNSCSIASMVLTTECMMVDHEKKDKGILDSSINSPNYLSKHRRTYKHKLHDDEDTDEDDEEDEDDEDDEDDEDDDDYDDEDEEDEEDEEDEDDEDDEDSMNDGYNYDE
Protein: Occludin (Q91049)
Organism: Gallus gallus (Chicken)
Function: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q16625}; Multi-pass membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q16625}.
Interaction partners:
- Tight junction protein 1
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- Proto-oncogene tyrosine-protein kinase Src
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
- Uncharacterized protein.
- Claudin
Sequence:
MFSKKSYDGPPAGYGPPTGYGAPTADYGYGSPPPGSYYVDDAPQLFYKWTSPPGAVRGLQAGVLVLCIAIFACVASTLAWDYGYGLGGAYGTGLGGFYGSNYYGSGLSYSYGYGGYYGGVNQRTANGFMIAMAVLCFLAQLGLLVAALSKSGATRSRRFYLAVLVLSAVLAFVMLIASIVYIMGVNPQAQMSSGYYYSPLLAMCSQAYGSTYLNQYIYHYCTVDPQEAVAAVCGFLIVILLCLICFFAQKTRSKIWRYGKANIYWDRAPVVQEGPDVEEWVKNVADGASVQDETATLAYSEKPTSPVAAPPYSYVPPPSAGYYPSGTYSSRGDQPDRALSASPVHGEEEEEKGKDQPSRPPARRGRRRRRNPELDESQYETDYTTAVESSDERDQEQWASLYPPITSDGARQRYKQEFDTDLKRYKQLCAEMDSINDRLNQLSRRLDSITEDSPQYQDVAEEYNQLKDLKRSPDYQSKKQESKVLRNKLFHIKRMVSAYDKVRG
Protein: Serpin family H member 1 (E9PRS3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDK
Protein: Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein) (Q768S4)
Organism: Mus musculus (Mouse)
Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells.
Subcellular location: Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the exocytic secretory vesicles by RAB27A.
Interaction partners:
- Double C2-like domain-containing protein beta
- Ras-related protein Rab-27A
- Double C2-like domain-containing protein gamma
- Ras-related protein Rab-3A
- Ras-related protein Rab-3D
- Ras-related protein Rab-3B
- Ras-related protein Rab-8A
- Double C2-like domain-containing protein alpha
Sequence:
MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRSQCLSPGELEIILQVIQRAERLDILEQQRIGRLVERLETMQRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTETQPPSAETSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPLPSGVKGTKGDKPRGDSGASMESPRLGPARPPSHLSGSQSSLGSEAGTGATEPQGGTPAQPEPRVPGKRHTWATPRY
Protein: Phospholipase A2 A2-actitoxin-Cgg2a (A2-AITX-Cgg2a) (EC 3.1.1.4) (CgPLA2) (Phosphatidylcholine 2-acylhydrolase) (D2X8K2)
Organism: Condylactis gigantea (Giant Caribbean anemone) (Condylactis passiflora)
Function: Sea anemone phospholipase A2 (PLA2). When incubated with plasma, this protein shows a moderate anticoagulant activity (0.15 ug of enzyme/200 uL of plasma), inhibiting clotting induced by thrombin. This enzyme also induces myotoxicity, and edema. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular location: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
Interaction partners:
Sequence:
GVWQFAYMIAKYTGRNPLDYWGYGCWCGLGGKGNPVDAVDRCCYVHDVCYNSITQGPRPTCSRIAPYHKNYYFTGKKCSTGWLTSKCGRAICACDIAAVKCFRRNHFNKKYRLYKKNIC
Protein: Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (Q8K2Q5)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion intermembrane space {ECO:0000305}.
Interaction partners:
- Zinc finger protein PLAG1
- Epidermal retinol dehydrogenase 2
Sequence:
MPMVTRRLRDPDINPCLSESDASTRCMDENNYDRERCSSYFLKYKNCRRFWNSVMIQRRQNGVQPSMPTAAERDEILGAMQKMPY
Protein: Ff1b (Steroidogenic factor 1a) (Q9IAI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MDFRADEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCTQNQDCGIDKTQRKRCPFCRFQKCLSVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKRALIRASGFKLEANGTLLSGQTEFSSVGLQSPYDCPPPALGVALQNYGSFPAQYQYTAPSLPKSIKAEYPDAYPSSPDSTLGYSYADGCLSASPHSVPINPALPPLVLELQSCDPDEEQVRGKICAYLHQEQSGRGKLEKSRPSSLLCVMADQTLFSIVEWARSCVFFKELKVGDQMRLLHNCWSELLLLDHICRQVHHGRDGSLLLITGQEVELSAVLDAGPPLSSMVERGQDLSRRLQLLQVDSREMACLKFLILFNPNVKLLENPQFVESVQEQVNGALLEYTLFSYPQCVERFSQLILRLPELRSLSAEAEDFLCYKHLCGEVPCNNLLIEMLHAKGSSAQ
Protein: GPI mannosyltransferase 2 (EC 2.4.1.-) (GPI mannosyltransferase II) (GPI-MT-II) (Glycosylphosphatidylinositol-anchor biosynthesis protein 18) (Q09712)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GPI mannosyltransferase 1
- GPI mannosyltransferase 3
- GPI ethanolamine phosphate transferase 1
- Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit gpi15
- Dolichol-phosphate mannosyltransferase subunit 3
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase
- Large ribosomal subunit protein bL19m
- V-type proton ATPase subunit G
Sequence:
MYYIGHPSYYRKHIEHVCFQHSGILKKRNYQKNQKKYIMKLNESAMKNAEKKSNSYLAIRMTRSGYNYFKGICVCTFLLSTILYLGIAVIMSHLCVFDDTAMLYLRQNRSRLAESNIFRTLFISWIRWDAIYFVDMAVNGSLFEQEWAFSSLWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMSVGYTESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCPGVAWCNKSLPLIYPAVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPPA
Protein: Probable two-component-system connector protein YmgA (P75992)
Organism: Escherichia coli (strain K12)
Function: Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB.
Interaction partners:
- Probable two-component-system connector protein YcgZ
- Probable two-component-system connector protein AriR
- Uncharacterized protein YmgC
- Blue light- and temperature-regulated antirepressor BluF
- HTH-type transcriptional repressor BluR
Sequence:
MKTSDNERIKYEITGQAVLQILRMKINFSLQTLIKQLLVMKSAEEDAFRRDLIDSIIRDFSNSDSGGPNRRTATADNKSMFNGKKINRIH
Protein: Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) (Q13107)
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.
Interaction partners:
- Spliceosome associated factor 3, U4/U6 recycling protein
- TNF receptor-associated factor 6
- E3 ubiquitin-protein ligase TRIM21
- DNA endonuclease RBBP8
- Ubiquitin carboxyl-terminal hydrolase 15
- TGF-beta receptor type-1
- Polyubiquitin-C
- U4/U6 small nuclear ribonucleoprotein Prp3
- Ubiquitin carboxyl-terminal hydrolase 11
- TNF receptor-associated factor 2
Sequence:
MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSMDTN
Protein: Multidrug resistance protein MdtE (P37636)
Organism: Escherichia coli (strain K12)
Function: Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium.
Subcellular location: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Multidrug resistance protein MdtF
- Outer membrane protein TolC
- Probable aminoglycoside efflux pump
- Multidrug efflux pump subunit AcrB
- Multidrug export protein AcrF
- Transcriptional regulator GadE
- Multidrug resistance outer membrane protein MdtP
- Putative magnesium transporter YhiD
- Probable multidrug resistance protein EmrK
- Glutamate decarboxylase alpha
Sequence:
MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8Y425)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKGILKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Protein: MKIAA1489 protein (Q6ZPP6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
WNTIMSTQEERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAAALQMIIAYAYTGNLAVNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYRQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRVKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSPDGTEEFELDGEMVALPPV
Protein: RabX6, isoform B (M9PE35)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI01544p
- RE60063p
- non-specific serine/threonine protein kinase
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- General vesicular transport factor p115
Sequence:
MATMRIPKQKVILCGDYGVGKSSLFRRFATNTFITDTDRKSTLGLDHIDREYSVNEKQIKLQLWDTGGMERVASVTSSYYKFAEGAILVFALDNAASFHSLSQHLLDIVTYAENAKIFICGNKSDLDGREPEVSDEEVEAFCEQCHSLISATYKTSCRSGAGVEEMFRDISRQLVHANRSKMELQALEHKSFQVDTASSGAATNEEDASSCGCXQLGNIEFG
Protein: SNAPIN protein homolog (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (O44445)
Organism: Caenorhabditis elegans
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein
- KxDL domain-containing protein
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- BLOC-1-related complex subunit 8 homolog
- Dysbindin protein homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- BLOC-1-related complex subunit 5
Sequence:
MSSTAGGEVSINSGDLLLGTLSTSITKLEQQIRATQLSQKKLNSDCETMAEYLRDLSEYKQPVDLLPYVGKLNDSTIRVNNTHQKLDDLLERLTKLQRQIARETYKKKNSIKEQEPPVQPEN