Protein: Condensin-2 complex subunit hcp-6 (Holocentric chromosome-binding protein hcp-6) (Holocentric protein 6) (Q95Y84)
Organism: Caenorhabditis elegans
Function: Chromosomal protein which is recruited to mitotic chromosomes by hcp-3 (CENP-A) and hcp-4 (CENP-C). Involved in chromosome segregation during mitosis, playing a role in chromosome condensation and in maintaining chromosome morphology, rigidity and orientation during mitosis.
Subcellular location: Nucleus {ECO:0000255|PIRNR:PIRNR036508}. Chromosome, centromere {ECO:0000269|PubMed:12080088, ECO:0000269|PubMed:15767665}. Note=Localizes to the centromere during mitosis (PubMed:12080088). Co-localizes with hcp-3 (CENP-A) at prophase, metaphase, and anaphase chromosomes (PubMed:12080088, PubMed:15767665). Mitotic chromosome localization is dependent on hcp-3 (CENP-A) and hcp-4 (CENP-C) (PubMed:12080088, PubMed:15767665). Localizes along two parallel lines on individual prophase chromosomes (PubMed:12080088). At metaphase, localizes at the poleward faces of the metaphase plate (PubMed:12080088). During anaphase, localizes with the separating groups of sister chromatids (PubMed:12080088). {ECO:0000269|PubMed:12080088, ECO:0000269|PubMed:15767665}.
Interaction partners:
- CAP-G condensin subunit
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin-2 complex subunit kle-2
- Structural maintenance of chromosomes protein 4
- Condensin complex subunit 1
- Condensin complex subunit capg-1
- Chromosome condensation protein dpy-27
- Condensin complex subunit dpy-26
- Aurora/IPL1-related protein kinase 2
- Structural maintenance of chromosomes protein 3
Sequence:
MSNINEKDLSEFLESNLRSLNDIDDAVATSSAECNYEDYEEFTNSVDLTFFEQDLSGVLKELKKLAESVVISGKKCDIRNIFEESDVATMKFNLFVWYFLENGQRSDSSEEDVDKGVSAASSYIAMCSLPGAISDLYQIGLYNQCLKIIRNCCHTVRIGETVVTKKSSGAKKKKAGGKSDETNVDGEMTVTTGAADPIIGPPRIAVDSAERYLHHLTTQLFAFLHSNTFSIDTPTLMSTLEVVEDIGRLDLDNRTAGRAIRANSVHEFRSLERFTDRYCAFVHSLVESKYKTRAEVAYGRLIRPRLALMPYPDESNKSSKISTERKRSGELHVNLILSRISRNPEARELKYIQTVTVMVYSQCPDLAEFRTNIATFIHKILEALPYTYTYDFVQFMNVLFKGRGAGVKSLSTELSSILISSFDFTAPDPGAIPNLDAEQNEEEDEEEEGEDEEEEEENEQDDVAVKEEEQSDKSDEENDGDNEENVSKKKEEKKKEKKAKEVKEVGRMDAMSVLYNIVYMACLDKAAAMRLHGANSLTKILQSQSHREAFQLFCATINAEMDEKFGAVGDNLSESLEDLNVSGKAPSSKTKKPTDLLLDEQQIIQKFNKLKLMNKGETRVEKDIVYMIVRRLSTDDKAPVKKAACSLLKSYLSYCDEASKFEVVLSILQMLCRDRMVSVRKTGADAFTELMLRDAILFKESLSSKWLHTLISMLNDTDNDVTEHARKLIMKVLTPLLENSSDLTWTLLDTIESVTNHRQYLMSTLKDAVREKLVKRTVMDSMKQHIISGSEKLDGAWMVFSQLCVQFEQNVDFAIETFSRVDLSRESNLVQYMIHVIENNIKKIDDDTKSDLVNTLQGTFRDYCLHPSHSRSIYHCLGKLMDGIGDRSLHGKEFSDFGETLLIKCFDTIVQSFEMFKDKDEWKRNSESQERLLCTALNVASEVFSYSPQLVPRHERLGKTLSLIVNSTENGSSDASTVNPDMPSVHHTRPPTQLSEVPSSQKSSKGGMMSHEGAMFSDKVRAVGVVTLANMILAHDRLLKLMPMLVKQLQYNTAHQIRSNIVLAIGDICSSYKTDRYAPMLAASLCDPSVIVRRHAINQIARLISFGIFRFNGEIMIRMMLASLDANEDVRNDAKLYISEVLQSEEPNFFPLNFVQYMIALTQARRLVGVGHDEDDRGQVDVAIGGGDPLARPSRIAIYTFMIDSLDDRSRFDVKMSICQRIFTPIVNGEYDFSDYNVQCLLDDALLIMASNEMQVKMDVGKNPNENAMDDPSPEVLEAATGFMQKVYLDHYMKTIVPSILSLREFLNQHRSPLQRKCLLAIRMICIEHKNDIDEILQDNRQLKDEMMFELQRVKQRTEEANRILDEYLKRVAEFKKQQKRLSKSPAPMELDAEPVQESAEAVEMGSPARRIEEDQENVEEEVEMRTPQKKNPDADVPRTPLNALRSTTEEKSTPNARLLSPKTIKKIRRSLGALIHTEMRLNPPNLEETKIDDTTINRSKQADKTEEKTIVEEEPMEEAAAEKTVTAENDHVDAEKTVIAVEIPPATEAEEDEVVDVQSESRRSRRRKTPNYDDEESVDADGKIWKKPKIVNKSPEKEVNISANVTLRRSRRGQSTEPPVVKENSNRKRKSVDEEEENVPTSSSGNTENDPLSRGVTPLIFDESKLGAGRHCSTPIRSREDADPSDVTFSLNLSAITEKEDLKNRSKKVKLITFTISSKRMKRKADQCHCINLPSKFVLFISTVCIIVRLSAVFSLN