wanglab/gogpt-training-data huggingface dataset:
Protein: tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) (Q9VK89)
Organism: Drosophila melanogaster (Fruit fly)
Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Interaction partners:
- LD47550p
- tRNA-uridine aminocarboxypropyltransferase 2
- tRNA
- Ribosome production factor 2 homolog
- tRNA
- LD41718p
- Lethal
- Nucleolar complex protein 2
- tRNA
- Ribosome biogenesis protein BOP1 homolog
Sequence:
MEVDEEKPQIIAENPNENVIRERNAEIVSGGNVFYNPVQEFNRDLSIAALNVYRQRLTKERSEKALKKQRKKVKEQEDEKTTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYAQEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYGCPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIESHANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNPTAGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQRRIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAPPAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENPTPHWGPGTRATIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQDTPQAVDEYDGDVEHLPKQPKLEATA
Protein: Decapping protein 1, isoform A (Decapping protein 1, isoform B) (Q9W1H5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- m7GpppN-mRNA hydrolase
- Enhancer of mRNA-decapping protein 4 homolog
- 5'-3' exoribonuclease 1
- Enhancer of mRNA-decapping protein 3
- ATP-dependent RNA helicase me31b
- Protein associated with topo II related - 1, isoform A
- Trailer hitch, isoform H
- NAD
- Regulator of nonsense transcripts 1 homolog
- U6 snRNA-associated Sm-like protein LSm1
Sequence:
MADESITRMNLAAIKKIDPYAKEIVDSSSHVAFYTFNSSQNEWEKTDVEGAFFIYHRNAEPFHSIFINNRLNTTSFVEPITGSLELQSQPPFLLYRNERSRIRGFWFYNSEECDRISGLVNGLLKSKDQGTNGQAQRHVSAPQQPKQDSSQPASIFNMLTKAQKDYNAQVSGGQPKTPSAENVTAGNVLKFFESAKQATAESLFHRVQPLSVDQLEKQQRAATPGEDLLPPAGRDNHESRLSPFQKMQQLNIQLLSDLKIGKSYATAQSPTVAPSSSALMANDDAGKCLRRLLAGDKPGPALMPPTMFDAPNNGNPEPQQPQQPQQPLLNSTQFVQAFTYLIQNDKEFANKLHKAYLNGCSNLLLDSSSTYQ
Protein: Probable glucan endo-1,3-beta-glucosidase BG3 (EC 3.2.1.39) (Beta-1,3-glucanase 3) (AtBG3) (F4J270)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in plant defense against pathogens.
Subcellular location: Endoplasmic reticulum {ECO:0000305|PubMed:23656331}. Secreted {ECO:0000250|UniProtKB:P33157}.
Interaction partners:
- Insecticidal crystal toxin domain-containing protein
- Putative purine permease 15
- Actin-related protein 4
Sequence:
MKMCNGSSFLASLPLLLLLLSFILASFFDTAVGQIGVCYGRNGNNLRPASEVVALYQQRNIRRMRLYDPNQETLNALRGSNIELVLDVPNPDLQRLASSQAEADTWVRNNVRNYANVTFRYISVGNEVQPSDQAASFVLPAMQNIERAVSSLGIKVSTAIDTRGISGFPPSSGTFTPEFRSFIAPVISFLSSKQSPLLVNNYPYFSYTGNMRDIRLDYTLFTAPSTVVNDGQNQYRNLFHAILDTVYASLEKAGGGSLEIVVSESGWPTAGGAATGVDNARTYVNNLIQTVKNGSPRRPGRATETYIFAMFDENSKQGPETEKFWGLFLPNLQPKYVVNFN
Protein: Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) (H3BRL8)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU363109}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU363109}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKKIH
Protein: Interleukin 18 binding protein (Q9JLN2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRHCGCAADPSPWWVLLLYVHVVILARATSAPLTTATVLTRSSKDPCSSWSPAVPTKQYPTLDVIWPEKEVPLNGTLTLSCTACSRFPNFSILYWLGNGSFIEHLPGRLREGHTSREQRNASTWLHRALVLEELSPSLLSTNFSCLFVDPGQVAQYHVILAQLWDGLKTAPSPSQETLSSHSPGPRSAGPGAP
Protein: Sarcosine/dimethylglycine N-methyltransferase (EC 2.1.1.157) (ApDMT) (Dimethylglycine N-methyltransferase) (Dimethylglycine-betaine methyltransferase) (Q83WC3)
Organism: Aphanothece halophytica
Function: Catalyzes the methylation of sarcosine and dimethylglycine to dimethylglycine and betaine, respectively, with S-adenosylmethionine (AdoMet) acting as the methyl donor. Activity with sarcosine is much weaker than activity with dimethylglycine.
Interaction partners:
Sequence:
MTKADAVAKQAQDYYDSGSADGFYYRIWGGEDLHIGIYNTPDEPIYDASVRTVSRICDKIKNWPAGTKVLDLGAGYGGSARYMAKHHGFDVDCLNISLVQNERNRQMNQEQGLADKIRVFDGSFEELPFENKSYDVLWSQDSILHSGNRRKVMEEADRVLKSGGDFVFTDPMQTDNCPEGVLEPVLARIHLDSLGSVGFYRQVAEELGWEFVEFDEQTHQLVNHYSRVLQELEAHYDQLQPECSQEYLDRMKVGLNHWINAGKSGYMAWGILKFHKP
Protein: Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) (P9WMM1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phosphoribosyl isomerase A
- Histidinol dehydrogenase
- Imidazole glycerol phosphate synthase subunit HisF
- Imidazoleglycerol-phosphate dehydratase
- Histidinol-phosphate aminotransferase
- Phosphoribosyl-AMP cyclohydrolase
- ATP phosphoribosyltransferase
- Probable inositol 1-monophosphatase ImpA
- Phosphoribosyl-ATP pyrophosphatase
- Bifunctional purine biosynthesis protein PurH
Sequence:
MTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADGLVVPGVGAFAACMAGLRKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPGCGHWPGAVIRLEAPVIPHMGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPDALLTWATYRAPFLAAVEDGALAATQFHPEKSGDAGAAVLSSWVDGL
Protein: Core binding factor alpha 1 (Q9DDG3)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASNSLFSSVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSEVSPVVVAQQQQQQQQQQQQEAAVPRLRPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVLTNPPQVAPYHRAIKVTVDGPREPKRHRQKLDDSKPSLFPERLSDLGGIPHPSMRVGVPP
Protein: Hexosyltransferase (EC 2.4.1.-) (Q57ZV2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MFARVKRVRQKRSMFLTVIALIIGIVVLRKLIHYSVQKHQEMSDEYADRRARYDPSPHVDTPFQYISPEVLETWKSRDYLVALGVLSPDISVRRRRRFLQRMTCWTFPDVATKRNNFTGAMIPLYVLARHPVHNFKYSDILKEEARHWEDIITLPIDEGRVSTNKKMGDGTFWGPETEVGMSRKTFMWLDLALNLFGTATFISKADDDMYLRVPQQLANIRVLPTHKLYYGYSMPNRYPYQFRYADGSVFTISRDIAEKVVGYRPLRRLANQSYDRAYLKHYLLLFMDHEDMMVGHTIFRVAKDVTYATVRRCHFHNIYGRFDVSPLTFNSIMLHNIKESEYADLMRHFSNIKPTPTRYVKTSEGIFFECEFHSGRPLHLGGRW
Protein: Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II) (P20155)
Organism: Homo sapiens (Human)
Function: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.
Subcellular location: Secreted {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28554943}.
Interaction partners:
Sequence:
MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC
Protein: RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) (Q9P260)
Organism: Homo sapiens (Human)
Function: Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes.
Subcellular location: Recycling endosome {ECO:0000269|PubMed:29514919}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29514919}. Note=Translocated to the trans-Golgi network area in an OSBP-dependent manner (PubMed:29514919). Colocalizes with RAB11A in recycling endosomes (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). {ECO:0000250|UniProtKB:Q148V7, ECO:0000269|PubMed:29514919}.
Interaction partners:
Sequence:
MAAMAPGGSGSGGGVNPFLSDSDEDDDEVAATEERRAVLRLGAGSGLDPGSAGSLSPQDPVALGSSARPGLPGEASAAAVALGGTGETPARLSIDAIAAQLLRDQYLLTALELHTELLESGRELPRLRDYFSNPGNFERQSGTPPGMGAPGVPGAAGVGGAGGREPSTASGGGQLNRAGSISTLDSLDFARYSDDGNRETDEKVAVLEFELRKAKETIQALRANLTKAAEHEVPLQERKNYKSSPEIQEPIKPLEKRALNFLVNEFLLKNNYKLTSITFSDENDDQDFELWDDVGLNIPKPPDLLQLYRDFGNHQVTGKDLVDVASGVEEDELEALTPIISNLPPTLETPQPAENSMLVQKLEDKISLLNSEKWSLMEQIRRLKSEMDFLKNEHFAIPAVCDSVQPPLDQLPHKDSEDSGQHPDVNSSDKGKNTDIHLSISDEADSTIPKENSPNSFPRREREGMPPSSLSSKKTVHFDKPNRKLSPAFHQALLSFCRMSADSRLGYEVSRIADSEKSVMLMLGRCLPHIVPNVLLAKREELIPLILCTACLHPEPKERDQLLHILFNLIKRPDDEQRQMILTGCVAFARHVGPTRVEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKEIRSSLVLSMLQQMLMEDKADLVREAVIKSLGIIMGYIDDPDKYHQGFELLLSALGDPSERVVSATHQVFLPAYAAWTTELGNLQSHLILTLLNKIEKLLREGEHGLDEHKLHMYLSALQSLIPSLFALVLQNAPFSSKAKLHGEVPQIEVTRFPRPMSPLQDVSTIIGSREQLAVLLQLYDYQLEQEGTTGWESLLWVVNQLLPQLIEIVGKINVTSTACVHEFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENIDSSAGNGVLTKATVPIYATGVLTCYIQEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYGVVHTSALVRCTAARMFELTLRGMSEALVDKRVAPALVTLSSDPEFSVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLRCLRTDMEHLSPEHEVILSSMIKECEQKVENKTVQEPQGSMSIAASLVSEDTKTKFLNKMGQLTTSGAMLANVFQRKK
Protein: Tuberous sclerosis gene product-1 homolog (Q9U9A9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVIEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGYIFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCIITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIAYLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSLPVLLPETSNEDGSYAYPMTPGYSRMTSNTSNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWSPHNEIATTSSGIPLTPTTSFILPLQPAMNSQLMVGMTGSSPPEAAVEATPETTPLKDMRDIKQPGRAVNSHAVRAIFAVSHPSSPMRKDQQSQFSFPDVSREAEESSHSYLEVNRGTAYDRRLSQVIQDRHNVERSVNTPCPSSLPEINSDLSLVGGSVYPSVTQEVAAVCGECNETDRNLCSVGGLHMPTSRSMHQLAKKRRNRMASYSGNGSCADSRSSAAKKASWSTEAENPMRRTKSCSALSGMRQQHLEENDDEADCSSQRQRGENGNTQKTGSRLQRSGRNLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLIELLLECKEQRIDYERNLLYPQDILDEYIKHAIKANESFDAEQGQLMCLQLEYESYRRSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQNIHQEELGEMRAKYQHELEEKKCLRQANDDLQTRLTSELARHKEMNYELESLRGQVFSLGTELQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQESSNLELKDLRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQKKIIMQMEEKLMMMMQQPQGTTGHNTCSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVDTPTIPDVLNSMAGGAQFEDEVRPPAVDLASSASTASAINIVPHALDLPSTSGGIGHTLTHPHPHPHLHLQQQQQDQLQ
Protein: Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) (Q61462)
Organism: Mus musculus (Mouse)
Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P13498}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13498}.
Interaction partners:
- NADPH oxidase 1
- Neutrophil cytosol factor 2
- NADPH oxidase organizer 1
- NADPH oxidase 4
- Neutrophil cytosol factor 4
- Ras-related C3 botulinum toxin substrate 2
- NADPH oxidase activator 1
- NADPH oxidase 2
- Neutrophil cytosol factor 1
- NADPH oxidase 3
Sequence:
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIAAGVLICLLEYPRGKRKKGSTMERCGQKYLTSVVKLFGPLTRNYYVRAALHFLLSVPAGFLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPPAEVRKKPSEGEEEAASAGGPQVNPMPVTDEVV
Protein: Gamma carbonic anhydrase-like 2, mitochondrial (AtCAL2) (GAMMA CAL2) (Q9SMN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in complex I assembly in mitochondria and respiration.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15821992}; Peripheral membrane protein {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15821992}; Matrix side {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15821992}. Note=Probably integral to the membrane. {ECO:0000250}.
Interaction partners:
- Gamma carbonic anhydrase 2, mitochondrial
- 2Fe-2S ferredoxin-like superfamily protein
- Gamma carbonic anhydrase 1, mitochondrial
- Acyl carrier protein 2, mitochondrial
- Excitatory amino acid transporter
- At2g31490
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Acyl carrier protein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8-A, mitochondrial
Sequence:
MATSLARISKRSITSAVSSNLIRRYFAAEAVAVATTETPKPKSQVTPSPDRVKWDYRGQRQIIPLGQWLPKVAVDAYVAPNVVLAGQVTVWDGSSVWNGAVLRGDLNKITVGFCSNVQERCVVHAAWSSPTGLPAQTLIDRYVTVGAYSLLRSCTIEPECIIGQHSILMEGSLVETRSILEAGSVLPPGRRIPSGELWGGNPARFIRTLTNEETLEIPKLAVAINHLSGDYFSEFLPYSTIYLEVEKFKKSLGIAI
Protein: Alpha-galactosylglucosyldiacylglycerol synthase (EC 2.4.1.-) (Q8DPV9)
Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Function: Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl-glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D-galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). It can only use UDP-Gal as sugar donor and alpha-glucosyl-DAG is the preferred sugar acceptor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9150233}.
Interaction partners:
- Alpha-monoglucosyldiacylglycerol synthase
- Phage shock protein PspC N-terminal domain-containing protein
- Extracellular protein
- Sensor protein CiaH
- DNA primase
Sequence:
MRKFPLFSSSLSFLLLILFKENDIIVVMEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVTENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVKRYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLRTDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYKTIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRDLDLYKVILEGNYRATAGREEMKEAILEYQANPAVLKDLKEKAKNISREYSEEHLLQIWLDFYEKQAALGRK
Protein: Fibronectin type III domain containing 1 (J3KNQ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKASKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW
Protein: Antifungal protein 1 (MAF-1) (P86696)
Organism: Musca domestica (House fly)
Function: Antifungal activity against C.albicans ATCC 76615.
Subcellular location: Secreted {ECO:0000269|PubMed:19728925}.
Interaction partners:
Sequence:
ESAPAPEVSGDAVFSAIQNGXLKNLGNAFFW
Protein: Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Q3SX44)
Organism: Bos taurus (Bovine)
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O95865}. Mitochondrion {ECO:0000250|UniProtKB:O95865}. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes. {ECO:0000250|UniProtKB:O95865}.
Interaction partners:
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- type I protein arginine methyltransferase
Sequence:
MGTPGEGLGRCSHALIRGVPESLASGEGAAAGLPALDLAKAQREHGVLGGKLRQRLGLQLVELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVTSTSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGQPGLPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHN
Protein: CCR4-NOT core DEDD family RNase subunit (Q5A8L5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- General negative regulator of transcription subunit 1
- CCR4-NOT core subunit
- CCR4-NOT core ubiquitin-protein ligase subunit
- CCR4-NOT core subunit
- mRNA decay factor PAT1 domain-containing protein
- General negative regulator of transcription subunit 3
- General negative regulator of transcription subunit
- ATP-dependent RNA helicase DHH1
- DNA-directed RNA polymerase subunit
Sequence:
MNVNPHLQYLQQQQQQQQQQQQQQQQSQPSQSNQSQSNQSPQFSQLQLQQLQRQQLLNQHLQQQQSQSQSSQVPPQLTQQSMGTPTSTNPLLAVLNGGANSNATSTGNGSLSSNPVLQQLQLQQLQQQVQLQQLQAQQQQQQQQQQQQQAIPIIKEVWSSNLEHEFQALRTFINDKTSKVFIAIHQEIPGIVARPVGTFKSSSDYHFQTLRANSDLLNLIQLSLCVIKISKNETISTPVIWQFNFLYDLTKEMYNEEHLAMLAQTSQINFQLLSTHGIPHFEFAELMIESGLILDDNINWVSFHAGYDLGFFVSLLSNDDLPVDEPDFYWWCAKYFPNFYDLKYIGNQILNKSTTNGAGGTNSNTLDEKTNKPSIEYLAEELHLLPISPAIRQHFTNSTFHSQQLTSTLHAYLSMECFKELLRRSNMTLLSSFKGTIWGLGTFSGGTSINNTNNNGVTEDEIVASRINGISTPSTPVGIISKSGMVHFGGRV
Protein: Small ribosomal subunit protein uS13B (40S ribosomal protein S18-B) (P0CX56)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQHTKTTGRRRA
Protein: Segmentation protein paired (P06601)
Organism: Drosophila melanogaster (Fruit fly)
Function: Pair-rule protein expressed in a segmentally repeating pattern to define the polarity of embryonic segments. Capable of sequence-specific DNA-binding.
Subcellular location: Nucleus.
Interaction partners:
- Segmentation protein fushi tarazu
- Protein odd-skipped
- Protein bowel
- Protein sister of odd and bowel
- Mitochondrial import inner membrane translocase subunit Tim22
- Fork head domain transcription factor slp1
- Zygotic gap protein knirps
Sequence:
MTVTAFAAAMHRPFFNGYSTMQDMNSGQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISRLVRGRDAPLDNDMSSASGSPAGDGTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGAPGGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVSSAFGQLPPTPNSLSAVVSGAGVTSSSGANSGADPSQSLANASAGSEELSAALKVESVDLIAASQSQLYGGWSSMQALRPNAPLSPEDSLNSTSSTSQALDVTAHQMFHPYQHTPQYASYPAPGHAHSHHGHPHAPHPHAHPHPQYAGAHPHYPPPSSSAHFMPQNFNAAAFPSPSKVNYTTMPPQPFYPSWY
Protein: Paired box protein Pax-6 (Oculorhombin) (P63015)
Organism: Mus musculus (Mouse)
Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:23990468}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P63016}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:21084637}. Cytoplasm {ECO:0000269|PubMed:21084637}.; SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}.
Interaction partners:
- Transcription factor SOX-2
- Barrier-to-autointegration factor
- T-box brain protein 1
- Transcription factor Maf
- Histone lysine acetyltransferase CREBBP
- Forkhead box protein G1
- Neurogenic differentiation factor 1
- Transcription factor SOX-1
- Oligodendrocyte transcription factor 2
- Homeobox protein NANOG
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ