wanglab/gogpt-training-data huggingface dataset:
Protein: Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) (Q96AQ6)
Organism: Homo sapiens (Human)
Function: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. Nucleus {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403}. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
Interaction partners:
Sequence:
MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG
Protein: Large ribosomal subunit protein mL46 (54S ribosomal protein L17, mitochondrial) (YmL17/YmL30) (P36528)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL4m
- Small ribosomal subunit protein uS11m
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL38
- Large ribosomal subunit protein mL43
Sequence:
MKVNLMLKRGLATATATASSAPPKIKVGVLLSRIPIIKSELNELEKKYYEYQSELEKRLMWTFPAYFYFKKGTVAEHKFLSLQKGPISKKNGIWFPRGIPDIKHGRERSTKQEVKLSDDSTVAFSNNQKEQSKDDVNRPVIPNDRITEADRSNDMKSLERQLSRTLYLLVKDKSGTWKFPNFDLSDESKPLHVHAENELKLLSGDQIYTWSVSATPIGVLQDERNRTAEFIVKSHILAGKFDLVASKNDAFEDFAWLTKGEISEYVPKDYFNKTEFLLADN
Protein: Alhambra, isoform K (A0A0B4KGB4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCERNNNKQVTSSNKIPSSFNAKLELDSSKDDTIHSTSLNKKLVKIKKFKLDDMKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSISTSGSALEDNNRWGTRNAKKSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSNATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSENLRLEEHVTSLIARRDHLLAVNARLQIPLSTIASNTKAEAHGK
Protein: N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP) (P51606)
Organism: Homo sapiens (Human)
Function: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
Interaction partners:
- N-acetyl-D-glucosamine kinase
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- N-acetylneuraminate lyase
- N-acetylneuraminate-9-phosphate synthase
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- Chitotriosidase-1
- Acidic mammalian chitinase
- N-alpha-acetyltransferase 10
- Renin
Sequence:
MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYDDLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQLQGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVSEGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHGGLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQFRDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPTPACRGAE
Protein: Heterochromatin protein 1-binding protein 3 (B0QZK4)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
KKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKN
Protein: Multiplexin, isoform F (E1JI50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAMVISTRAKLVITALILFFLLGIVLVTGSTKGWFNPNRYNGERVAARIQATDIFDASGMQPPGQTQYTHERPYRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAKGVPGEKGDAGQKGERGDPGHKGAHGPSGAKGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGRPGMTGPKGEMGPKGPKGDSGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPKGEPGVDSRSSFFGDASYYGRPEPPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTFTTAPEYETLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVEALSQDRKRKKREIGDGSSHGESESREFKTADEYAAHLENLLL
Protein: ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) (Q5W0B1)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.
Subcellular location: Chromosome {ECO:0000269|PubMed:31160578}. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase. {ECO:0000269|PubMed:31160578}.
Interaction partners:
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 11
Sequence:
MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPSKINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFAVAALQSKVEQYERETNRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALSADGKGSKGSEEDVVSKNQGDSARKQPGSSTSSSSHLAKPSSSRLCDTSSARQESTSKADLNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTPLSLSCLQLSTPENRESSVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRSENEKKSECFSSPKTGFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGLCLSKRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNEDFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSLHNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSSASPSKATKS
Protein: Guanylate cyclase domain-containing protein (H2L2G4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MESNGIQCKIHVSETGKLNGLKANPSYVFIDRGNTEIRGKGMMYTYFLERNDRKSVWELCSRPRSGEQTIDGYMELHDQSIYQEEGGQQENLTVENGNSAQNNHNNNNNTHHSGRKLMNGSSVDPGSHHIRSPTCTIS
Protein: Protein SGM1 (Slow growth on galactose and mannose protein 1) (P47166)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for normal growth rate on galactose and mannose.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Golgin IMH1
- GRIP domain-containing protein RUD3
- GTP-binding protein YPT6
Sequence:
MSKKLSLEERLSLATKKGRKKNKRSTSNLSSPSPVVLSNNEQESARTSIDDAAAGVVSIDNAENIDDPAVRSESTVEGDTGKADSIAVDDVVHPDHNRTDCFDDTMVSLPTWLPKNYTEFTVEELVKEISPEYLRLNKQIDDLTNELNRKSQIETTDSSFFKLIKEKDDLIDQLRKEGAKLAETELRQSNQIKALRTKVKDLEYEVSELNDSSAQSVENYNELQSLYHNIQGQLAEATNKLKDADKQKESLETLEKNIKEKDDLITILQQSLDNMRTLLEKEKSEFQTEKKALQEATVDQVTTLETKLEQLRIELDSSTQNLDAKSNRDFVDDQQSYEEKQHASFQYNRLKEQLESSKANWDSIEYALNTKIVNLENRFESTMKEKNDIEEKYQTALRSSETLGKQLEKEKENHSKAVLEVKDLERRAETLKSSLQSISDDYNLLKKKYEIQRSQLEQKENELKPHQENSNEKIIDKIPVELTDSLNSMEGNIEDEWTLPQENSMLSLSMSKLGELESDPSLKPIYNESHETICSEESQHFDRKNVDFSIDDIPEEAAALQAIREGESMNSLNNTSIPYRRASVQLSNSNGHISAHLVNKLSTELKRLEGELSASKELYDNLLKEKTKANDEILRLLEENDKFNEVNKQKDDLLKRVEQMQSKLETSLQLLGEKTEQVEELENDVSDLKEMMHQQVQQMVEMQGKMR
Protein: Neurite extension and migration factor (A0A2R8YEQ5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDNQQDKAIVASANGENTLINGVKENDSEDQDVAMKSFAALEAAAPIQPTPVAQKETLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGIAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDAVDPEPGISLKVGDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRRETEKPDIDLEDPAQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEDKGVEKKDGKDNGEKPALNKPCSGTEVEQLKNPKQGHLANSLETSGSFSDDSSFIEISYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPVGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIPSIEISASSKQISLCNDQRHASNHKEDGGLKGTLKSAPLGAPSCANGSHLNDITGPDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQESKPIVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPLSSANVTTNIPVIPGGYLQTLLDASDLSNNTSISYFSHHSPEQNEGSLTQTEKSFVPLQPTQDCVLTSSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNGEICFPFQQGPVNMDDGRLFSFDSMAPLSVSSSNYCSLSLKSCEKDGDDDITDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCESMKTLGTLKGFQEGVPGPLDSVEKIKWDCSTLSRQVQMEDGFTLNNHQFQFHMFNDEDSVSLLQKNPCLSTFNDPSGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNTRKKSLKGNNKGIEKPPGKNSRQVPKSTKKGKYMAAINGEKMQIGIGRGGSQTNTISSTGKTLAECIQHGGPMASMKMPSQKGLSGDWALGKESSPGWSDMSMGTNTNSLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKINSGSQGATKNHRSIKGVSKSNGKTAIGDPGRANMPGYNEDSRSTFFDKKYSNMSTLGNNGPTHKKLYRHKSSSKALRDEKCKGKHMEREQVHKDESGTASFEKLR
Protein: Probable FEIII-dicitrate-binding periplasmic lipoprotein FecB (O53291)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
- Probable periplasmic iron-transport lipoprotein
- Putative glyoxylase CFP32
Sequence:
MRSTVAVAVAAAVIAASSGCGSDQPAHKASQSMITPTTQIAGAGVLGNDRKPDESCARAAAAADPGPPTRPAHNAAGVSPEMVQVPAEAQRIVVLSGDQLDALCALGLQSRIVAAALPNSSSSQPSYLGTTVHDLPGVGTRSAPDLRAIAAAHPDLILGSQGLTPQLYPQLAAIAPTVFTAAPGADWENNLRGVGAATARIAAVDALITGFAEHATQVGTKHDATHFQASIVQLTANTMRVYGANNFPASVLSAVGVDRPPSQRFTDKAYIEIGTTAADLAKSPDFSAADADIVYLSCASEAAAERAAVILDSDPWRKLSANRDNRVFVVNDQVWQTGEGMVAARGIVDDLRWVDAPIN
Protein: Calcineurin binding protein, putative (AFU_orthologue AFUA_2G13060) (C8V1J5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit
- Calcineurin subunit B
Sequence:
MHQRNEMTGTLSPQSAPSSPSISTRRSSRSSQKPSLSIDLSSLPPLSQPSPPTNTLLITELNDLYLFQPSSLSQIRQLIESIAPLNSFSPLPSFRRIVASFRNEDDATRVRKLLDRESLLNRSVRTRIYFGEPTPLLETDDAGGIKHKLLEAPQVDKLFFISPPPSPPHGWVMRQEDPPNKEVHASDLAQALAKLKTQTEGSTYATSTVPASQQQTDPDTPMSLSSDKRTGSWPLLQQRSRSSTLIYNPEEHGGSPNLPAVMVEDTSADPDDMDVEMSPIDMPVKQTPPFKTARPPVELMV
Protein: DEAD-box ATP-dependent RNA helicase 1 (EC 3.6.4.13) (Q7FGZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- mRNA-decapping enzyme-like protein
- Protein decapping 5
- ATP-dependent RNA helicase DEAH13
- mRNA-decapping enzyme subunit 2
- Nucleolar protein
- DEAD-box ATP-dependent RNA helicase 16
- Peter Pan-like protein
- Uncharacterized protein At3g06530
- Enhancer of mRNA-decapping protein 4
Sequence:
MGRDKEDKTEMDSVVPWMRAPVDVSNVENCALDTLPCLNPKLKKALENMGISSLFPVQVAVWHETIGPGGFERDICVNSPTGSGKTLSYALPIVQLLASRPVRCLRALVVLPTRDLALQVKDVFDAIAPAVGLSVGSAVGQSSIAGEISQLIKTPKLDAGICYDPDDLSQNLESAVDILVATPGRLMDHINNTKGFTLEHLRYLVVDETDRLLREAYQSWLPTVLQLTQTSDDSLFPSFTPFVPSAFGSLQTVRRQSVERGFKGKPYPRLVKMVLSATLTQDPSKLIQLDLHHPLFMTTGGSRYRLPEKLECLRLICETGMKPVYLVALLKSWEGEKCIIFTSSVETTRRLCKLLNFFGDPKIKAKEYSGGLNQSLRSKELKAFRKGDIQVLVASDALTRGMDVKGVTNVINYDMPPFAKTFIHRAGRTARAGQAGRCFTLLSNHEVRRFSKLLEKVGSDSCPIYPIPPTSLDSIRATYTPALEKLKELVESEAPKKGRQAFRHNSRTGNSQTKLNKPRSEA
Protein: Nudix hydrolase 19, chloroplastic (AtNUDT19) (NAD-capped RNA hydrolase NUDT19) (DeNADding enzyme NUDT19) (EC 3.6.1.-) (NADH pyrophosphatase NUDT19) (EC 3.6.1.22) (Q94A82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives. Has a high affinity for NADPH compared with that for NADH.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18815383}.
Interaction partners:
- NAD kinase 2, chloroplastic
- NADH kinase
- Glutamine-dependent NAD
- Haloacid dehalogenase-like hydrolase
- Nicotinate phosphoribosyltransferase 2
- Nicotinate phosphoribosyltransferase 1
- NAD
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Alkaline-phosphatase-like family protein
- Nudix hydrolase 15, mitochondrial
Sequence:
MLALFLSSSSYPTLSFLSRSVTLNLARTTTLSALTMSMNLKTHAFAGNPLKSKTPKSTDPFSPTSAFESLKTLIPVIPNHSTPSPDFKVLPFSKGRPLVFSSGGDANTTPIWHLGWVSLADCKVLLASCGVDLNEDSLVYLGPKLEEDLVYWAVDLAEDGFVSELGGRKLCFVELRTLMVAADWADQRAMDELAIAGNARALLEWHNVSQFCGSCGSKTFPKEAGRRKQCSDETCRKRVYPRVDPVVIMLVIDRENDRALLSRQSRYVPRMWSCLAGFIEPGESLEEAVRRETWEETGIEVGDVVYHSSQPWPVGPSSMPCQLMLGFFAFAKTLDINVDKEELEDAQWHSREEVKKALAVAEYRKAQRTAAAKVEQICKGVERSQSLSTDFNLESGELAPMFIPGPFAIAHHLISAWVNQAPDDVHSKQQAGVSLSSL
Protein: Zinc finger protein GIS3 (Protein GLABROUS INFLORESCENCE STEMS 3) (Q9C9H1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Acts upstream of GIS, GIS2, ZFP8, and the trichome initiation factors GL1 and GL3. Binds the promoter region of GIS and GIS2, which may be direct targets of GIS3.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SLB8}.
Interaction partners:
Sequence:
MEELDFSSKTTTSRLKLFGFSVDGEEDFSDQSVKTNLSSVSPERGEFPAGSSGRSGGGVRSRGGGGGGGERKYECQYCCREFGNSQALGGHQNAHKKERQQLKRAQLQATRNAAANFSNAGSASQFLRNPIVSAFAPPPHLLSSSAVPQPMGGPWMYLPRVSPSQLHVSHGCVIQDGSGGAGAGGFSYEYGARDSGFGVVGAQMRHVQAHGPRPSVNGFSREVGTTFDDGLGLDLHLSLAPAGH
Protein: Centromere protein J (E7FCY1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- SCL-interrupting locus protein homolog
- Spindle assembly abnormal protein 6 homolog
- Serine/threonine-protein kinase PLK4
- Centrosomal protein of 135 kDa
- Abnormal spindle-like microcephaly-associated protein
- WD repeat domain 62
- Pericentrin
- Centrosomal protein of 63 kDa
- CDK5 regulatory subunit-associated protein 2.
- Intersectin 2a.
Sequence:
MMSSPAGLQQGQINFISHWVPDSTRAGVILHGSPGDASSGSVRSSGSLVVQDPDDSFISQFAPLPISRSSSCASVDMCSLGGGSKTPGETQLSDASLNSEMQSIQDILRNTRDLPLIAKLEQLKQMQYRMQEQLKAHQQEQLLRQQREPQRLLAIPQNTAETTVCNREPSVVALNTEHDSHYEFEESLQSTTEDQTMYRKESDSEPQDRPIKSGFGGRTFEEILEEQLKMENQKLTNENPPAKSVKVKRPFLKRGEGLARFTRGKATVPSNRKSPPNPKPSSGQNPKKSQVLDMKSKRNSINKSEGSKSTHPMIQRKTAVLNKENFPQNKTTGPVTKMTLQPHVLVAHQGQNMGSISAQILPKPDPLSNMKINNATPTDCNKERECNRIKDNASVAENSFEVWFTERREHWEQDHKRERAELGEFELLERAADEISFSSNSSFISTLLQRDRRRLSSTPIKSTGQSTLPSQALGPTAAPGLMLGHRAPAPPINTAIQKDIVSIELKELCHEETDEKFDDSSCSNSELEPLSNISNPPINHFQVPITLPYDKRTYQDRDGASSPEGDDRNSSHNEDSTLKDSRTQLEFDDDDTWNDPEDESSCPVEESPSERMLKRKVAFSKGVKPVGGSPKAGANRNEAPSTSQLVAKLFPALKPKPSPVMMPEPQNKPSEEGAAQSRLLRERLVELETEIERFKSENAALARLKQENQDIRENLKKDKADFEKKRIEETAKWEEYKSEEYKKMQREKKLFEKHAATVRARPDKQERDEIQALKQQLNMMQEDLRKREARWSNTQKRLRQQVESLSSENTSLRDQVRTLEKLRLSAWKSAEKEKEKGRSSTSSSRTSTGSKPTDSKSPSHSSKGNSSRKGSPETQISLTDSAFFPEVKETQSFKSELSPLVNQSSGVLVMNERSQDAPLNNSFPKLTITGQTNEKQEEIMQSDSKIEKMLPDGGRLVVFPNGTRKELSADGQTVKVMFFNGDVKHTMPDQRVIYYYAEAQTTHITYPDGMEVLQFPNNQTEKHFPDGRKEITFPDQTVKTLHPDGREESVLTDGTIIQLNPDGSKVIQFNTGQREIHTADFKRREYPDGTVKTVYSDGRQETQYPTGRVRLKDPQGKVIMDTKA
Protein: Synaptogyrin-1 (O43759)
Organism: Homo sapiens (Human)
Function: May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62876}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62876}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
Interaction partners:
- Synaptoporin
- Synaptophysin
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Synaptotagmin-1
Sequence:
MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPTGPDPAGMGGTYQQPANTFDTEPQGYQSQGY
Protein: Probable pectinesterase 48 (PE 48) (EC 3.1.1.11) (Pectin methylesterase 48) (AtPME48) (Q9LY19)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular location: Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Cellulose synthase-like protein D4
- Cellulose synthase-like protein D1
- Probable galacturonosyltransferase 13
- Proline-tRNA ligase
- Polygalacturonase QRT2
- Protein RALF-like 22
- Probable galacturonosyltransferase 14
- Pectinesterase inhibitor 1
- Pectinesterase inhibitor 2
- Probable pectate lyase 3
Sequence:
MRYTNVSILLGMLVIFVSPMVFADDLTPIPEGKPQVVQWFNTHVGPLAQRKGLDPALVAAEAAPRIINVNPKGGEFKTLTDAIKSVPAGNTKRVIIKMAHGEYREKVTIDRNKPFITLMGQPNAMPVITYDGTAAKYGTVDSASLIILSDYFMAVNIVVKNTAPAPDGKTKGAQALSMRISGNFAAFYNCKFYGFQDTICDDTGNHFFKDCYVEGTFDFIFGSGTSMYLGTQLHVVGDGIRVIAAHAGKSAEEKSGYSFVHCKVTGTGGGIYLGRAWMSHPKVVYAYTEMTSVVNPTGWQENKTPAHDKTVFYGEYKCSGPGSHKAKRVPFTQDIDDKEANCFLSLGYIQGSKWLLPPPAL
Protein: Paired immunoglobulin-like type 2 receptor beta (Activating receptor PILR-beta) (Cell surface receptor FDFACT) (Q9UKJ0)
Organism: Homo sapiens (Human)
Function: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Paired immunoglobulin-like type 2 receptor alpha
- Tyrosine-protein phosphatase non-receptor type 11
- CD99 antigen-like protein 2
- CD99 antigen
- Leukocyte-associated immunoglobulin-like receptor 1
Sequence:
MGRPLLLPLLLLLQPPAFLQPGGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRRSGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRVALAVAVLKTVILGLLCLLLLWWRRRKGSRAPSSDF
Protein: Integrator complex subunit 14 (Q9VPY0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5.
Subcellular location: Nucleus {ECO:0000269|PubMed:23097424, ECO:0000269|PubMed:39032490}.
Interaction partners:
- Protein asunder
- Integrator complex subunit 1
- Integrator complex subunit 10
- Integrator complex subunit 11
- Integrator complex subunit 9
- Integrator complex subunit 6
- Integrator complex subunit 5
- Integrator complex subunit 12
- Integrator complex subunit 3
- Integrator complex subunit 8
Sequence:
MPTLIALDASLSMLRPVPGRNEHTYQSLATKGIQHLLDNLTAAGKLEHVALLSYSTTAELKVDFTRDYDQVRQAVKKVEPVDKACLMSMLKAVVSIMSPWGNQNILQVVVFTDCGLGFGNTSITGFLEAYAEKESEPEFGFLKTLANYNLNFICLGLHGDYYFTRGLAVYQQLLDKVSLKGQLFMTKPAKSSDAVEGNPNPNPNPSHKSELGRTTVFELIERLCEASYKSSEVTLKCGSYFRMEASVLLWPPTAPYEQKSHIFGREPTIRHTDQKIEVCGFLSLSDIGSPATLSRHWVLPKVEREKSGSSRRSGNLSAAAKPPKLNLDTSNPNYELEKLEADIKEFYAKDSKDTEESGDDDVTIVLKPGPQTEQQKENLCVLLHGALKMENMAALVRVGDKWYGFIYAFTDSKKKSNLMLNILPPGTNVIPWLGDLESLGFPEDLAPGETASFPVRADRRSYSQSSVVWIRQASLQSDVQKVLRHAKKMPDKTQHFYKELNRIRRAALALGFVELLEALAMLLEKECAHLSLNGASNDCTLQLQHAATELRKTSNRDMKSMIVPLQKVGASDAGSTAATAPAPAYMY