wanglab/gogpt-training-data huggingface dataset:
Protein: Protein arginine N-methyltransferase 1.5 (AtPMRT15) (AtPMRT5) (EC 2.1.1.319) (Shk1 kinase-binding protein 1 homolog) (Q8GWT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylates arginine residues of myelin basic protein (MBP) in vitro. Methylates symmetrically histone H4 of the FLC chromatin to form H4R3me2s, which in turn suppresses FLC expression to induce flowering. Regulates alternative splicing by methylating spliceosomal proteins. Involved in the post-transcriptional regulation of the circadian clock.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Chloride conductance regulatory protein ICln
- Flowering time control protein FY
- Histone H4
- Serine/threonine-protein kinase RIO1
- Serine/threonine-protein kinase RIO1
- Cytochrome P450 72C1
- Actin-related protein 4
- F10B6.17
- Wee1-like protein kinase
- Sm-like protein LSM4
Sequence:
MPLGERGGWERTESRYCGVETDFSNDVTHLLNFNISTGGFDYVLAPLVDPSYRPSLVEGNGVDTQVLPVCGSDLVLSPSQWSSHVVGKISSWIDLDSEDEVLRMDSETTLKQEIAWATHLSLQACLLPTPKGKSCANYARCVNQILQGLTTLQLWLRVPLVKSEGDSMDDTSEGLNDSWELWNSFRLLCEHDSKLSVALDVLSTLPSETSLGRWMGESVRAAILSTDAFLTNARGYPCLSKRHQKLIAGFFDHAAQVVICGKPVHNLQKPLDSSSEGTEKNPLRIYLDYVAYLFQKMESLSEQERIELGYRDFLQAPLQPLMDNLEAQTYETFERDSVKYIQYQRAVEKALVDRVPDEKASELTTVLMVVGAGRGPLVRASLQAAEETDRKLKVYAVEKNPNAVVTLHNLVKMEGWEDVVTIISCDMRFWNAPEQADILVSELLGSFGDNELSPECLDGAQRFLKPDGISIPSSYTSFIQPITASKLYNDVKAHKDLAHFETAYVVKLHSVAKLAPSQSVFTFTHPNFSTKVNNQRYKKLQFSLPSDAGSALVHGFAGYFDSVLYKDVHLGIEPTTATPNMFSWFPIFFPLRKPVEVHPDTPLEVHFWRCCGSSKVWYEWSVSSPTPSPMHNTNGRSYWVGL
Protein: Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20) (Q96AZ6)
Organism: Homo sapiens (Human)
Function: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16514659}. Nucleus, nucleolus {ECO:0000269|PubMed:16514659}. Cytoplasm {ECO:0000269|PubMed:31600344}. Nucleus, Cajal body {ECO:0000269|PubMed:16514659}. Cytoplasm, P-body {ECO:0000269|PubMed:31600344}.
Interaction partners:
- Ubiquitin-like protein ISG15
- Interferon regulatory factor 9
- Signal transducer and activator of transcription 1-alpha/beta
- Interferon regulatory factor 7
- Interferon-induced protein with tetratricopeptide repeats 2
- Interferon-induced GTP-binding protein Mx1
- 2'-5'-oligoadenylate synthase-like protein
- Signal transducer and activator of transcription 2
- Guanylate-binding protein 1
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
Sequence:
MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVSD
Protein: Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) (Q8VHW8)
Organism: Rattus norvegicus (Rat)
Function: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. According to PubMed:18817736, shows only specificity for GRIA2 and specifically to the form of GRIA2 for which a single amino acid in the pore region has been edited from a glutamine to an arginine residue. Thought to stabilize the calcium channel in an inactivated (closed) state.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000269|PubMed:18817736}.
Interaction partners:
- Protein cornichon homolog 2
- Glutamate receptor 2
- Glutamate receptor 4
- Voltage-dependent calcium channel gamma-4 subunit
- Glutamate receptor 1
- Glutamate receptor 3
- Voltage-dependent calcium channel gamma-3 subunit
- Protein cornichon homolog 3
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2B
Sequence:
MSTCGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGIILPQNQSTEVKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNSQMTSESTVNVLKMIRSATPFPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQFLHPDAWIRGRSPSDISSDASLQMNSNYPALLKCPDYDQMSSSPC
Protein: Rifin (Q8IEU8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYTNILLFPLKLNILVNTHKKPHTTARHTQKIPTTRSLSECELYAPVNYYSDPQMKEVMDNFNKQTQQRFHEYDERMKTTRQKCKDKCDKEIQKIILKDKLEKQMAQQFSTLHTDIQSDDIPTCICEKSLADKVEKGCLRCAQNLGGVAPGWGLLSGFGYVTWSQYISGIAAKAAADAGLKAGVKVGLVNAVKIVTKTLDGFGEVPTMDWAKLIAFGDFSDGVTLHAIFKNLNNMMNCYLDSGKYSQFSTVVQKFAENPRSYATPYSTEVTEVTKAVADAKTGVLTKAGNATSSLSTGITASIIAIVVIVLIMVIIYLVLRYRRKKKMKKKLQYIKLLEE
Protein: tRNA/rRNA methyltransferase SpoU type domain-containing protein (Q38DC9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL29m
- 50S ribosomal protein L13, putative
- 50S ribosomal protein L17, putative
- Large ribosomal subunit protein uL3m
- Ribosomal protein L11, putative
- Large ribosomal subunit protein bL21m
- KOW domain-containing protein
- Acyl carrier protein
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
Sequence:
MHWPHGKCGIVLTVRLPLLMVDAMPRKNFLRAPLSHSFMHIGFAIMSQRRWQSTIGEQRPTARRSKNAYSHPLAPKDPASRNIVVPDAVHAKVGSPDTLPAEILQKRAQRALLMQLQQNVIWEGTVISDERHHLIQHFVKLRQNPKYRSSKQMMVVGGRHLLHELHKRGYTPRHLLVREGQQKPKWATNTGVKTEIIRVDRHVADVCSPGNDGFIGDFDIPKPPPKESLIANKQRFDRVLVLDNVDDPGLLGTVLRTAAGFHYDAVIATNHCADLYDHRVIRAARGAHFQKAVPIYTLKEEDGDNVYGMLNHILQRNDLSPVCFAARDDNDATDELGDLVRQLRSGCAQPKSRTSPCGSPAVKRETLSDYCRNNFTKSDAKGQLLMVGPNHKRNSVRRWSKQLSIPVTQLLLDEVSQTDALIAFSVVLHALRPHGNWDYLPLHNNQEQQETASLELQGMKASVDIGPNRFDLNEKDLSLDEEEQVEKARLDNELMRWRRLQRAQGSDYDHWMEAETRRIQEMASNESRKQVSPWARLRTRWQKGAAGMPPWVPNIVDEYRTPLDRDALRVEREVSESHVRPENYDR
Protein: Chimaerin (Chimerin) (Q7ZUT6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Multimerin 2a.
Sequence:
MAIHVFDNDEYRPPVWKSYLYQLQQEAPHPRRVTCTSEVENRPKYYGREYHGLISREDGDLLLSVAEGSYLIRESQRQPGTYTLALRFGNQTRNFRLFYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTINPIYEHVGYTTLNREPALKKTLPVCKDLPDGKHSPAEDSGLEERLTSLVRRATLKESERVPKYEKVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHNAKRPMVVDMCIREIEARGLQSEGLYRISGFSDLIEDVKLSFDRDGEKADISVNVYEDINVISGALKLYFRDLPIPVITYDAYPRFIQAAKLTDPDERLEALHEALKLLPPAHCETLRYLMAHLKRVTQNEKDNLMNAENLGIVFGPTLMRAPDLDAMTALNDIRYQRQVVELLIKNEDILF
Protein: Proline dehydrogenase (PRODH) (EC 1.5.5.2) (Proline oxidase) (TtPRODH) (Q72IB8)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Function: Converts proline to delta-1-pyrroline-5-carboxylate. Has significant activity against O(2) producing superoxide during proline oxidation catalytic cycle.
Interaction partners:
Sequence:
MNLDLAYRSFVLGVAGHPQVERLIKHRAKGLVRRYVAGETLEEALKAAEALEREGVHAILDLLGEMVRTEEEARAFQRGLLELVWALAGKPWPKYISLKLTQLGLDLSEDLALALLREVLREAEPRGVFVRLDMEDSPRVEATLRLYRALREEGFSQVGIVLQSYLYRTEKDLLDLLPYRPNLRLVKGAYREPKEVAFPDKRLIDAEYLHLGKLALKEGLYVAFATHDPRIIAELKRYTEAMGIPRSRFEFQFLYGVRPEEQRRLAREGYTVRAYVPYGRDWYPYLTRRIAERPENLLLVLRSLVSG
Protein: Stereocilin (Q8VIM6)
Organism: Mus musculus (Mouse)
Function: Essential to the formation of horizontal top connectors between outer hair cell stereocilia.
Subcellular location: Cell surface. Cell projection, kinocilium. Cell projection, stereocilium.
Interaction partners:
- Otogelin
- Otogelin-like protein
- Cation channel sperm-associated protein 2
- Lipoxygenase homology domain-containing protein 1
- Cell adhesion molecule CEACAM16
- Protocadherin-15
- Espin
- Transmembrane channel-like protein 1
- Glutaredoxin domain-containing cysteine-rich protein 2
- pre-mRNA splicing regulator USH1G
Sequence:
MALSLQPQLLLLLSLLPQEVTSAPTGPQSLDAGLSLLKSFVATLDQAPQRSLSQSRFSAFLANISSSFQLGRMGEGPVGEPPPLQPPALRLHDFLVTLRGSPDWEPMLGLLGDVLALLGQEQTPRDFLVHQAGVLGGLVEALLGALVPGGPPAPTRPPCTRDGPSDCVLAADWLPSLMLLLEGTRWQALVQLQPSVDPTNATGLDGREPAPHFLQGLLGLLTPAGELGSEEALWGGLLRTVGAPLYAAFQEGLLRVTHSLQDEVFSIMGQPEPDASGQCQGGNLQQLLLWGMRNNLSWDARALGFLSGSPPPPPALLHCLSRGVPLPRASQPAAHISPRQRRAISVEALCENHSGPEPPYSISNFSIYLLCQHIKPATPRPPPTTPRPPPTTPQPPPTTTQPIPDTTQPPPVTPRPPPTTPQPPPSTAVICQTAVWYAVSWAPGARGWLQACHDQFPDQFLDMICGNLSFSALSGPSRPLVKQLCAGLLPPPTSCPPGLIPVPLTPEIFWGCFLENETLWAERLCVEDSLQAVPPRNQAWVQHVCRGPTLDATDFPPCRVGPCGERCPDGGSFLLMVCANDTLYEALVPFWAWLAGQCRISRGGNDTCFLEGMLGPLLPSLPPLGPSPLCLAPGPFLLGMLSQLPRCQSSVPALAHPTRLHYLLRLLTFLLGPGTGGAETQGMLGQALLLSSLPDNCSFWDAFRPEGRRSVLRTVGEYLQREEPTPPGLDSSLSLGSGMSKMELLSCFSPVLWDLLQREKSVWALRTLVKAYLRMPPEDLQQLVLSAEMEAAQGFLTLMLRSWAKLKVQPSEEQAMGRLTALLLQRYPRLTSQLFIDMSPLIPFLAVPDLMRFPPSLLANDSVLAAIRDHSSGMKPEQKEALAKRLLAPELFGEVPDWPQELLWAALPLLPHLPLESFLQLSPHQIQALEDSWPVADLGPGHARHVLRSLVNQSMEDGEEQVLRLGSLACFLSPEELQSLVPLSDPMGPVEQGLLECAANGTLSPEGRVAYELLGVLRSSGGTVLSPRELRVWAPLFPQLGLRFLQELSETQLRAMLPALQGASVTPAQAVLLFGRLLPKHDLSLEELCSLHPLLPGLSPQTLQAIPKRVLVGACSCLGPELSRLSACQIAALLQTFRVKDGVKNMGAAGAGSAVCIPGQPTTWPDCLLPLLPLKLLQLDAAALLANRRLYRQLPWSEQQAQFLWKKMQVPTNLSLRNLQALGNLAGGMTCEFLQQISSMVDFLDVVHMLYQLPTGVRESLRACIWTELQRRMTMPEPELTTLGPELSELDTKLLLDLPIQLMDRLSNDSIMLVVEMVQGAPEQLLALTPLHQTALAERALKNLAPKETPISKEVLETLGPLVGFLGIESTRRIPLPILLSHLSQLQGFCLGETFATELGWLLLQEPVLGKPELWSQDEIEQAGRLVFTLSAEAISSIPREALGPETLERLLGKHQSWEQSRVGHLCGESQLAHKKAALVAGIVHPAAEGLQEPVPNCADIRGTFPAAWSATQISEMELSDFEDCLSLFAGDPGLGPEELRAAMGKAKQLWGPPRGFRPEQILQLGRLLIGLGERELQELTLVDWGVLSSLGQIDGWSSMQLRAVVSSFLRQSGRHVSHLDFIYLTALGYTVCGLRPEELQHISSWEFSQAALFLGSLHLPCSEEQLEVLAYLLVLPGGFGPVSNWGPEIFTEIGTIAAGIPDLALSALLRGQIQGLTPLAISVIPAPKFAVVFNPIQLSSLTRGQAVAVTPEQLAYLSPEQRRAVAWAQHEGKEIPEQLGRNSAWGLYDWFQASWALALPVSIFGHLL
Protein: PHD finger protein-like protein (PHD type zinc finger protein) (C0SVJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetratricopeptide repeat
- General transcription and DNA repair factor IIH subunit TFB5
- Chaperone DnaJ-domain superfamily protein
- General transcription and DNA repair factor IIH subunit TFB1-3
- General transcription and DNA repair factor IIH subunit TFB5
- General transcription and DNA repair factor IIH subunit TFB1-1
- General transcription and DNA repair factor IIH subunit TFB4
- Chaperone protein dnaJ 6
- General transcription and DNA repair factor IIH subunit TFB2
- Probable F-box protein At3g61730
Sequence:
MASGVFEDEAEGTITINEYIERLDAEELAADLVLGGDEGDECTFPKGYMKRQAIFSCITCTPEGNAGICTACCLSCHDGHELLELWTKRNFRCDCGNSKFGTLACKLLPSKDIENSENSYNHNFKGLYCTCDRPYPDPNVEEQVEMIQCCLCEDWFHEEHLGLTPSDSVGSQIPRDEESEPIYEDFICQNCSPACSFLTLYPENLWVVAKVDSTGSANACSETIELDKNHMDSEPGQPENGTDAEKSVVGKCSETISDSEPGQPENGTEAEKSVVQKCSEKIDESEAGQPENSTEAEKFVVRKCSEKIDGSENVPAAGCVIRTDLNSCPEFEKKPLFLTKNWRNILCRCEKCLEMYKQRKVSYLLDAEDTIVEYEKKAKEKRTEKLEKQEGEALDLLNNLDHVSKVELLHGIKDFQDGLQGLMESAGPSKAITSADIEQMFSKLKNKRKRME
Protein: phenylalanine--tRNA ligase (EC 6.1.1.20) (Q382C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- phenylalanine--tRNA ligase
- 40S ribosomal protein S5, putative
- tyrosine--tRNA ligase
- Elongation factor TU, putative
- Tyrosyl/methionyl-tRNA synthetase, putative
- Large ribosomal subunit protein uL5
- Leucine-rich repeat protein
- threonine--tRNA ligase
- Uncharacterized protein
- isoleucine--tRNA ligase
Sequence:
MSTMENTILKALVGSEVIKSDVLAQELGVDHQVVVGAIKSLEAGGYVTSEIEKRPTWKLTAEAIKICEEGSPEFQLWELLAAGEMPQDAVAGKLGRDVTAVALSNGMKTKTFVLRKEDGKVIINRSPSVSSFRDTTRLVLSDAARNQHIDPKDGDMLKKRKLATLEDIKVFSVRRGPSFAPEVRGKAAGDLTKEMLLDGSWRTTEFKAYNLAAAGREVSCGQLHPLLKVRQEFREIFMEMGFQEMETDHWVESSFWNFDSLFIPQNHPARDMQDTFFISKPATSELKQQDVVENVRKMHEKNFKYTWKESEARRNVLRTHTTSCSAFWLHHLARNSPLLPDGRRAFRPGRYYSIDRVFRNEEMDRTHLCEFHQIEGCVIDRNISLANMMHTFELFFRRIGVERLRFKPVFNPYTEPSMEIFGWHTQLKRWIEVGNSGLFRPEMLVPLGFDEDVTVMAWGLSLERPTMIKYGLSSIHELFGHKVDLRFIRNSKLMRF
Protein: NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] (P55769)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
Subcellular location: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797}. Nucleus, nucleolus {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus. {ECO:0000269|PubMed:10593953}.
Interaction partners:
- U4/U6 small nuclear ribonucleoprotein Prp3
- U3 small nucleolar RNA-interacting protein 2
- Peptidyl-prolyl cis-trans isomerase H
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- U4/U6 small nuclear ribonucleoprotein Prp31
- U4/U6 small nuclear ribonucleoprotein Prp4
- Nucleolar protein 58
- Pre-mRNA-processing factor 6
- Nucleolar protein 56
- rRNA 2'-O-methyltransferase fibrillarin
Sequence:
MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV
Protein: Limpet, isoform K (Q7KUQ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAEETALTGVGELLFSLLIGYLGALEFAFVARHLYHWTFQHPGDSSVDAAADAEELPRMRERLDKQIKEAAEREALAGTNVMQDGVLYVNGIRVDPAGDKRQALAAELARQQQIEADTRRQLAEAEAKLVEERLRVQREKEESEEQQRKLVEAERQREREQAEKELQEQREAERRQLEAEENQRKQRENEEKERLENERRLIDAEREREENERRLQEAEEQREREESERRIVVAERQREQAEAEKERAEQQRILAEAEAAQAERRLFDAEIQRERDQADEEGQALRDAEIVERLLAAERELSPSATESELEEDAAIAEQSRRLISSRTDLEQKQRMIEENARRFLEAEEEMVMLQQRQLQASHSKEEADEYAGMEPVVEELCVKKVAPPRFQEPPEEPMVHKVKTQFGQGSGPEDAYSAKSKTLTFPGVSDEGSSLEPKTPFSIQQSSFSTQPSDEGNRIESERPEPEGEDQIQEVQYTEDYLRSLDGIKNRPLMREDGSGRRRAFKKRRSSGSSNSSRESRASRDEELKMFTSLEEEELRHGDREDYNPIKYTSEPTLRVKSHRRHKRSPAKDVRPTAESTTSLEMLGEESTNPWGEVVPEHYKDTEFWKREKALSIDEEEIELERPSRGEDVEEEATNEPKSSSFEEATEAQNEQAVAALKQQLSKEQLDKEAEKDNPQAVDTSDSNKSNLQTSIAAEEQSRGGSPGLRRSPRMDEMEHYPERWSASQEQQSVQQQPPRTAPAINVQQPDTAPWRDQYGLLMEGLSDFYDFTASVNPSRSRSASRNPSPAPKNVANLMDGDTERSLEVYDDTQEGVMAGELNCESVLQLLESNLNETESTNDQLQVQTVADDARDGKSILPMVHEPLESSALGAVLEERGREPSVGRIQSRSRSRSRSPLPTSENLEKSIHKRRERLIKQNDELAERLSHSSPEDSMEIETSDNGRLSPTLEVTLPQPVIEINEMADEPMEDAETTPEEMRLFVETLRAERNARSRSRSRSRSPLPTAGNIEKSLESRRLKRIQHNDEIFEKLHDQMSSPQIIIESASPPSLPLPLPTISIEIAEPPEENASHTEAEPEDTPESMARLFEQLRLNRVRSHSRSRSRSPLPTPANLEQSVQKRRERLIAQNDQFFEVLQERARTPEPETRLTVEYVYEYVQEKDEQVGEGRDKRSLSPSRSRSQSQEKALDDFHLMLNLEGSELRTLRKNSEELESVLAVGAKQREVDMDALEKLHNANEEIELRVLSPTNSELERVVEMTRENPDMDRTVSEVARDLQDELMASGFKRSTYVGESLDLGSDQFKELRREAAQFQRSRSPSPGSSMDYAREQAAAQRELQTAILDSLTESRLGAKPKTYSEERTGEFEDISAAQLDDLRHRTAEFQRSRSQSRSPLREVELTQLRDIEAESAKRELQDQLLDRLAASSINFENFSRHLNADFLDSERRASDSALMGDMEPDEYHHFRRYSLAQEQPVEEYPSDDYVYISQIEVRTLTGTRTWLKEDFYTHEPNDFSDSKSPVRDEDSWARAVLAAEAEAAEFDSTNAIYSYDIVGDHENLDQERSSSNDSEDTRQTVVEIDDEDEFEFELDEGISDNNERTQPTDESHHDTSECEEAERNADRYENRGAQDWEEVDDVEDFLDYGFDDGAVGGATPYSDPDSFIEQIYNEAIKNRKQSGILREYETIVQEQLPSDLSESEKEKSGSDSEKYALWAKTRELERSHSGTRHSDVDIALGLIPESDHRDSEMRYLGDAHVVARQSTRLRTRYGFNPKLEVGDLEDDIEVDLNYKPKREYNWRKNFRLDDNEEGERSVQVKTEEDEEQEARDQFEEEFGWQDREQELEEELYQDHEQPLYANEENGEIENVELLENRRISLGGESITLFSRSPVREILPDVPEELPQEEEALEEQPEAVAPLEDLPAEKPKKKKSKKKLRKGSKTEEELRDDNDSDTQMGSSRRSDDQEPTDPPKRKTRSRRSSRSSLTNEEPNGGSGPFSPRSSLAFVGESLEGIAEFEPQEREEEQSTKKRTKKRKKTSTKECKEEAKEETQTQAIDDSQLDRALAAALAEIAPVSVSTNLTPESTHQNLLSTISTGQSVCITPASSIEEIGGSPSSTSTTVAAVVPARSVVDTFDILKDANFYPLF
Protein: Aquaporin PIP1-3 (AtPIP1;3) (Plasma membrane intrinsic protein 1c) (PIP1c) (Transmembrane protein B) (TMP-B) (Q08733)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg(2+).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7920711}; Multi-pass membrane protein {ECO:0000269|PubMed:7920711}.
Interaction partners:
- PAMP-induced secreted peptide 1
- Probable aquaporin SIP2-1
Sequence:
MEGKEEDVRVGANKFPERQPIGTSAQTDKDYKEPPPAPFFEPGELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVFYIVMQCLGAICGAGVVKGFQPNPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHAWDDHWIFWVGPFIGAALAALYHQLVIRAIPFKSRS
Protein: Tar DNA-binding protein homolog 1 (D0VWM8)
Organism: Caenorhabditis elegans
Function: RNA-binding protein which regulates transcription, splicing and RNA-editing. Limits the accumulation of double-stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs. Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion. Plays a role in maintaining localization of chromobox protein homolog hpl-2 to gene bodies, perhaps acting via binding to nascent RNA transcripts.
Subcellular location: Nucleus {ECO:0000269|PubMed:22792076}. Cytoplasm {ECO:0000269|PubMed:22792076}. Note=Shuttles from the nucleus to the cytoplasm under stress conditions. {ECO:0000269|PubMed:22792076}.
Interaction partners:
- RNA-binding protein FUS
- ALS/FTD Associated gene homolog
- DUF1014-domain-containing protein
- Homeobox domain-containing protein
- ProGRaNulin homolog
- RRM domain-containing protein
- SUMO-conjugating enzyme UBC9
- UBC core domain-containing protein
- Serpentine Receptor, class T
- RRM domain-containing protein
Sequence:
MADETPKVKTEPAAEVKSPLDEVKEIRKEAELTQTGSDEKKTTDPEFITVQDPNGDEPIELPTVDGVVLMTTLQASFPGATGLKYKNPKTGANRAVQVDPSGLKLIAPADGWENKTFFVIVAPQSERVRALSSADATSAKRRKVGSSDDSDSDDGRDGRSGRKRAVERDSQPVDLIVLGVDFKTTDECFQKYFEDIGTVVFCEIKRKSDGNSKGFGFVRMSSVGEQNKVLAIPQHMIDGRRCDVKVPDGRSLQDKQGRPSISRIFVGRLTDKVDEHQLRKVFGDEAKSYIETAVVTDVFIPKPFRGFAFVTLSSAEAAERIVSKGSLTVNGLSVGLSIAQPREENNQSVGPDYGLPAGYRNRRERDRPDRRPIQNEAPLPMPFVRPPQDYSYRQQNSPLERRYWAPGDSRGPGW
Protein: Mitf, isoform D (H9XVQ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTESGIDLGFDMEFDLNINLLNDNDNMDFLPNVTENMEFYELKSSSRCIRHNEIPTFKTATPTSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDDCCGINCSTSCYIQHQLTSREGHPNHSHHTGIREIHSLSDSAQNSEFSRLEHCDDPLLSSSHRSLGTVDEDQHNSVDMSAVMVHDSLSSLVDDNNSETMVLASDTLDIEL
Protein: Ldb3 protein (RCG42332) (Q5XIG1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000256|ARBA:ARBA00004216}.
Interaction partners:
Sequence:
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPIQSPLPVIPHQKVVANSPANADYQERFNPSVLKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSLPVKDLAVDSASPVYQAVIKTQSKPEDEADEWARRSSNLQSRSFRILAQMTGTEYMQDPDEEALRRSRERFETERNSPRFAKLRNWHHGLSAQILNVKS
Protein: Pyruvate carboxylase (EC 6.4.1.1) (F1QYZ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Citrate synthase, mitochondrial
- Malate dehydrogenase
- L-lactate dehydrogenase A chain
- Pyruvate dehydrogenase E1 component subunit alpha
- L-lactate dehydrogenase B-A chain
- ATP-citrate synthase
- glutamate dehydrogenase [NAD
- Malic enzyme.
- Malic enzyme
- Malic enzyme
Sequence:
MLLHLGGSRAKTGILFIRRAGLFCRSAHLSSQTLEYHPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLSPVAAYLHIPDIIKVAKENNVDAIHPGYGFLSERADFAQACAEAGVRFIGPSPEVVRKMGDKVEARALAIKAGVPVVPGTDAPISCLQEAQEFAKTYDFPIIFKAAYGGGGRGMRVVRNYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPAAHLDSHLRDRLTLDSVNLAKQVGYENAGTVEFLVDKHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLEQDKIQINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAIISPHYDSLLVKVIASGKDLPTAATKMHRALTEFRVRGVKTNIPFLQNVLSNSQFLYATVDTQFIDENQNLFNLKPTQNRAQKLLHYLGHVMVNGPMTPIPVKAKPSPVDPVIPSVSLGEPPLGFREVLLREGPEGFARAIRQHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVSHNFSNLFSLENWGGATFDVAMRFLSECPWKRLQELRALIPNVPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYIPNMLLGMEAAGAAGGVVEAAISYTGDVSDPMRQKYSLDYYLKLADELVKAGTHILSIKDMAGLLKPQASRLLIEALRDRFPDIPIHVHTHDTAGAGVAAMLACAQAGADIVDVAVDSMAGMTSQPSMGAIVACTKGTKLDTGISLDKVFDYSEYWEVARGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYTEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLSLAEVEKRADELSFPLSVVEFLQGHIGIPHGGFPEPFRSKVLKSLPRIEGRPGASLPPMDFEALESGLRAAHGDEITPEDVMSAAMYPKVFQEFKEFTSTFGPVDCLNTRLFLDGPKIAEEFQVELERGKILHIKALALGDLNKSGQREVFFELNGQLRSVLVKDTAAMKEMHFHPKALKDVRGQVGAPMPGKVVEVKVKAGQKVEKGQPLCVLSAMKMETVVNSPISGIISKVHVNADSSLEGEDLILEITE
Protein: Postreplication repair E3 ubiquitin-protein ligase rad18 (EC 2.3.2.27) (RAD18 homolog) (RING-type E3 ubiquitin transferase rad18) (O74747)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 2
- Proliferating cell nuclear antigen
- DNA repair protein rad8
- DNA repair protein rhp51
- ATP-dependent DNA helicase srs2
- Ubiquitin-conjugating enzyme E2 13
- N-acetyltransferase eso1
- Ubiquitin-conjugating enzyme spm2
- Inheritance of peroxisomes protein 2
- Structural maintenance of chromosomes protein 6
Sequence:
MNELDATDPSDWNQTKIPSLKGLDSSLRCLICHEYFRAPLITSCSHTFCSFCIRDYLREHPMCPACRAPEQESRLRKNTILEEILESFKVIRPTLFEFLKVENVPKPVLQAPETVIAQDSASGDEEWEDDLASNSSPASIAKKTSRDSKKRKREDLVHCPACSNLVPHNQINQHLDSCLNSPSSPSSSSSPYKNKDNSKSNSLLSFKTDDDSITKRRLRSFNSADELPLKDRVRLPKLTYALLSESKIRSKLSEMGLPTDGHKQLLQRRHAKWVTLYNSNLDQKQPVSKRNLIRQLIDWERVQSKSIGVEKEKLGGGDWEKAYAEDFADLINRAKQSTTNKNDSLRNTAVESSTEPSTSNGFPATSVSPPLTIDLTNSQTGSDGPQS
Protein: La-related protein 1 (La ribonucleoprotein domain family member 1) (D5MCN2)
Organism: Caenorhabditis elegans
Function: RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development. Binds poly-U and poly-G stretches of RNA in vitro. Regulates target RNAs expression either by regulating their stability or translation.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:18515547}.
Interaction partners:
- Reticulon-like protein
- Putative H/ACA ribonucleoprotein complex subunit 4
- Germinal center kinase 1
- MIF4G domain-containing protein
Sequence:
MAEKQPMLSFAKVVSGQAEDASSPSQQVQHTQDSSHSSTQNENSQPEKQAHPPHNRREKENVGGRSERPRGEGKGKRRNNRKGDRKPRGETKTEKPAEKVATEEVKPVEIPVVLEPAPLPAINAWFKNKEEAEAAAAAAQKEQKSETAADQFIITATPVVQKSSAPIPEKKRAVEPTPKQAAPIKEKSKSRESKKEPWKTSTAPAATAPVTETVTVAATQDWPTLAKAELNGHVSPSNSDDNNESSSNSQHKTGGKMTKNSWKKVDISVDYGSKGKGAPRGNGGEKGTRRSANDEAVRRRSGEEDSASGDEQQYWSRSKDNKSPINEMSSDRVVDSGSNGIYYQQGGTHGWKKKVNNKAGSDMPTPPNSTSPHQSESNSPEHLPKDKAPIMNGNAKNAPAANRNGNNTSTAKTGDYWHKNGGERKEDKSQPKAYYQRNDRFQARANPHAPPKLTAAQRKERGPLPRWEDIEAGDDNFDYMTLMEAQYSQYYGAPQQFEHQLDPHQASILIQQAQQHMASFAPFRPPMPMLSPHLMSPPLDRDGGVTSPVSNGEPINTAIPFAPIYNPPTAPRPVTDDTLKEYVRKQIEYYFSEENLQKDFFLRRKMGPEGYLPVALIASFPRVRSLTEDYSLILEALKDSTKVDMSPDGLQIRAPVNPTIWPLMPTVSGADSLPGPSSQAPQQFRQNGPAATAAPVESQPQASSSKPQQPEEWEEVKTRKGKGKGRLTSGSQSTNDNKRQPQQQQKSLQQSGSDQPDLDFQFDNEISGGGGSAQTPKRPEKSKKAFLSAIDSEEIGDDVISKLIIMTPSRRTLDRTGDFSTRSQNQGEFNEEVEIGLRRYEEELWTVPQEKDIPTSKVSTISAEQFNEMRGNEDAKKTSDEPPEIPLPSGTQPTPDSVWTKKAKERAAASVTVPKSPMQRRESEEQKMNRFYPISKPTAPLDAKSPRKKKTRHSEKPPVEMPVAWVLGREDALPAAPIGIAASSSQVPANHPSISLLQEDRFVQNVYSTWRQACLKQRKSLGYDCAEMNTLYRFWSFFLRDNFNRNMYEEFRKLALEDAEIGSRYGIEALFRFYSYGLEKKFRPEIYKNFMKDVTTDVQKGELYGLEKLFAFLQRSKIAKQLVVDDYLTKELNKYKSTDDFRNLPQSTKK