wanglab/gogpt-training-data huggingface dataset:
Protein: Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6) (Q96DN6)
Organism: Homo sapiens (Human)
Function: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Subcellular location: Nucleus {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}. Chromosome {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}. Note=Associates with heterochromatin containing chromocentres in a subset of cells in a DNA methylation-independent manner (PubMed:20700456). Localizes to sites of DNA damage independent of the PR-DUB complex (PubMed:24634419). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}.
Interaction partners:
- Putative Polycomb group protein ASXL2
- AOF1 protein
- Ubiquitin carboxyl-terminal hydrolase BAP1
Sequence:
MNGGNESSGADRAGGPVATSVPIGWQRCVREGAVLYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPAKNKRRKLAP
Protein: Alcohol dehydrogenase 3, mitochondrial (EC 1.1.1.1) (Alcohol dehydrogenase III) (ADHIII) (YADH-3) (P07246)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:1101965, ECO:0000269|PubMed:2188098, ECO:0000269|PubMed:2943982}. Mitochondrion inner membrane {ECO:0000269|PubMed:2937632}.
Interaction partners:
- Alcohol dehydrogenase 4
- S-
- Alcohol dehydrogenase 1
- Alcohol dehydrogenase 5
- Alcohol dehydrogenase 2
- Pyruvate decarboxylase isozyme 1
- Pyruvate decarboxylase isozyme 3
- Pyruvate decarboxylase isozyme 2
- Aldehyde dehydrogenase [NAD
- Magnesium-activated aldehyde dehydrogenase, cytosolic
Sequence:
MLRTSTLFTRRVQPSLFSRNILRLQSTAAIPKTQKGVIFYENKGKLHYKDIPVPEPKPNEILINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVKLGSNVKGWKVGDLAGIKWLNGSCMTCEFCESGHESNCPDADLSGYTHDGSFQQFATADAIQAAKIQQGTDLAEVAPILCAGVTVYKALKEADLKAGDWVAISGAAGGLGSLAVQYATAMGYRVLGIDAGEEKEKLFKKLGGEVFIDFTKTKNMVSDIQEATKGGPHGVINVSVSEAAISLSTEYVRPCGTVVLVGLPANAYVKSEVFSHVVKSINIKGSYVGNRADTREALDFFSRGLIKSPIKIVGLSELPKVYDLMEKGKILGRYVVDTSK
Protein: Polycomb protein Pcl (Polycomblike protein) (Q24459)
Organism: Drosophila melanogaster (Fruit fly)
Function: Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. Required for the correct spatial expression of the homeotic genes of the Antennapedia and Bithorax complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:7956837}. Chromosome {ECO:0000269|PubMed:7956837}. Note=Associated with chromatin. Colocalizes with many PcG sites on polytene chromosomes. It also associates with many unique sites on polytene chromosomes.
Interaction partners:
- Polycomb protein Su
- Histone-lysine N-methyltransferase E
- Polycomb protein esc
- Chromatin assembly factor 1 p55 subunit
- Jumonji, AT rich interactive domain protein 2
- Polycomb group protein Pc
- Histone deacetylase HDAC1
- Integrator complex subunit 1
- Integrator complex subunit 3
Sequence:
MMNNHFHLQHDHPPQNVAHPFMQQPSTAVPSAPPATYGYLAQPAGQQPQWMTTTYQILPPSVGPATVAKRYYATTGPQTTHPTHPSTIQITNSFAQQSTPPKQQAATSCSPFKANNIRIISTAPSVYSLNKPPQEAHSTYAPVQSYYLPSGGGQTAGQINLLAASGTGKQLQPPPLVPVTNSTSPPSTVVLDRINICINNHYTETPTSLSSSLTTAQQPSPIIPAIQHKAILPLIDSSTADSSSCSSSSVSSSSYSGTATTSAAVVIVDEPDSTTTTPQTPPTTPEAMSSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPPPAPPVAAPSPAVTYALQEDVFIKCNDGRFYLGTIIDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTESTNTSPSGPMCVACKRSDIEDVVEICERCGRGYHRGCTVEIVTGSGIWSCKRCAKPMKMQQPVSHKITKPAGICRQLPYHADKLSWDEKHRVNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMERLKQTLKDYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELPKRVPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGGDTATTAIGLLGN
Protein: Metabotropic glutamate receptor-like protein M (Q54LG8)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
Sequence:
MIKLILSLIFLIICCNINPSESFKLITLTTGPTSDLGFNNMVNQGRIGVSKAMNIEDSRIFIVSGRNETYALLLPLIQNDDIDLVICSSQDHGDACKEIAAMYIDSPTIKTQFLVRGSGAATKNLIQITYNYASVNYISGMFAGLQTVKNKIGFLSPGSAANNNDSFVYAFWIGAKQVNPDVKFYYYNIGSYLDQDKTIAATQDLINIYGCDVIADTLDDFSAGNVAIQNNQYAMGTNGFPQRDVYGENVIFSYAYNWTKYFLPIAGSVANGTVPGKWYADFNKEDNYNFYDLSFGFKVSQNTKDLLIQKSRVLATTPRAGHPYYCNEYIEQYTKKYNLPTQAANSSCISTAGFFYINQPVGDMIYLGSYNIRLSKIEFSSSVQKGFSIVSGCLIAFVILMMVGIVYYKDTPSIRSASPIFLNFSLIGGIIIYIGIIIWVGPISTHQCNARFWLVTLGFSTLIGSLVVKNFRIWLIFDNPELKAIKITNYQLFPWVGLCLVINIVLMAILTSVGDLKAIEAQGIDSLGKYEYMTVCKMNSAGASTLYSILAYFAALLLVGVFVSWKIRIVDIEEFNESKAIANTLYAVSFCLFVIVPLMISPQEKQSETIILCVAGLFITTAALLIVFIPKFWRVFIYGKEGTNEMFKQKKSSSVATARAESLSKNSSNGGAHSGGGAVKTNRRGNIVSGDFTDDSESSLSEPNKPTKNNDGNVNVTAGAVLAEFTDDTISEFDENEVNEEPVKTESQE
Protein: Sorting nexin-7 (A0A0R4IIY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Sorting nexin 4.
- Sorting nexin 2.
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
Sequence:
MSVPAVDNTVSSGNASVAIPADMSGQMLDLDEDDDLEVFSKDTTITDGSSFNASMQTSPASMINQYKFEEEEEDVGTKDIFVTVDNPESHVTAIETYITYRVMTKTTRSEFDSSEFEVRRRYQDFLWLKGRLEEAHPTLIVHPLPEKFVMKGMVERFNEDFIETRRRALHRFLNRIAEHPIFSSTEDFKIFLTAASEELISHKKQGPGFLSRMGETVKAVAASVRGVRNRPEEFNDMQEYVEAFSQKINSLDKVTQRIIREQREYLEELKECGPTYTLWSNSEQELAEPLKNMADCLDRCYKETDEQVKQLNDQLSPALHEYVLCTETLKAVIRRRDNIQADFEAKTEALATKKADREAMKDDLEKLEDRLEWANNALKSDWTRWNKVMRTDLRSAFVDTAERNVSYYEKCLAIWESFLHSQRTDAEANGKADFS
Protein: Protein toll (P08953)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for the cleaved activated form of spz, spaetzle C-106. Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo. Promotes heterophilic cellular adhesion. Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by tey. May also function in embryonic neuronal survival and the synaptic targeting of SNa motoneurons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15373972, ECO:0000269|PubMed:1879347}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:15373972}. Note=In the fat body, detected in puntate structures along the cell periphery. Becomes evenly distributed in the cytoplasm 1 hour after bacterial infection. {ECO:0000269|PubMed:15373972}.
Interaction partners:
- Protein spaetzle
- LD20892p
- Dorsal-related immunity factor Dif
- Serine/threonine-protein kinase pelle
- NF-kappa-B inhibitor cactus
- Protein Tube
- Tehao, isoform A
Sequence:
MSRLKAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNGKSHGNGHINGAFIINTNAKQSDV
Protein: AP complex subunit beta (Q3ZB97)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}.
Interaction partners:
Sequence:
MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN
Protein: No poles, isoform B (A0A0B4KFV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLNLNCVICAELFGQADEVFATVCGHMFHHNCLNQWLDRSKTCPQCRNKCTTRNIFRVYFNLANLDVSHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRDLKETQKKCLKTIAGLEQKVQKKDFLISSYVEQIGVLKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADADRLLKNEADPHVLANWVSTLKRELRQCESKKTELRNVVKVVQNDLRKEIELKRKLEERVSHLESDLYQAQEKLQAFENKTAYLDSPNASCGLNSNILALKREERRTTISPTVENIKRIEESTSPYLNIKSSSVGLAHLLNTKGNIGLAKSKISPIKGVGGGVSMTSGTIRKTSSDLSEKYSIFKKPRLLLGSSSSSALTATTGSNFVYNGMGGSEKVDPFAQRAEEEGLSTIRSSTALSRNVNQRLKAGSLRNFNLGK
Protein: Protein let-756 (Lethal protein 756) (Q11184)
Organism: Caenorhabditis elegans
Function: Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.
Subcellular location: Nucleus {ECO:0000269|PubMed:16495308}. Membrane {ECO:0000269|PubMed:9331368}; Peripheral membrane protein {ECO:0000269|PubMed:16495308}.
Interaction partners:
- Myoblast growth factor receptor egl-15
- Receptor tyrosine-protein kinase let-23
- EGL-17
- Protein ver-1
- Probable syndecan
- Tyrosine-protein kinase receptor ver-3
- Insulin-like receptor
- Tyrosine-protein kinase receptor svh-2
- receptor protein-tyrosine kinase
- Protein kinase domain-containing protein
Sequence:
MAVPAASSIVSYGGAATSNFLTTPVTPFLAGFYNSNFVTDRINSCAPYRVDRIRKQLQDEEENGYPPADDRRRGALFCRSGTWLEMLPIENPDDGSTRVKVHGTKEESSKFSIVEFVSVAMSLVSIRGVETKNFICMDPSGKLYATPSSNYSTECVFLEEMMENYYNLYASCAYGDRFNPWYIELRRSGKPRRGPNSKKRRKASHFLVVHHDLDRLRSPVPNGNDVTDLVVASLFHQPPSHPLFRQQTVTKPPNPHRISNLRAKVEMTNQAEKQRLLEEKKRRREKKKRRREDRLRKEEQIREARRQELKSLREEELRRRYQQQQQQQASTQTRYNRPQNPANPYPTYRPLPTRSTVQSPRPAYNPYWQSPVTQAPHHNSHHHHHHHPRVSSSSDPQQRHQSQQHYLAQTVSNPNRQNVNYQRYP
Protein: Uncharacterized protein (Q586Q0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWPSPLILPPFFLLFLPLATHEVYIRNLLEVRNRYFFLLPRQHKHDFYTYSLQHWISGNDMALQRRGAFLLRQIRTEFSLDDMKKKAKEINRRNRSILQKRKRFAEPYPYSKAQYIDAFVQAQSARLAREQRLQELSTREKSLLTTIESSNPSPIIRNEGRHSLSCFSSTAGANTPVVFGSWRDGTTEVERACNFMDRNFHCIMRGATTPPAFSTPSLRRNLPMTLACVQQLLKYAGGDGPQGNTGETWSNRRIKTFNRTFASCVESACLKERDAILKLMGVVLQTAGERDWAVALQLYNKSVLPYFERHWIQQNHEKRREAVSFLVAVLCESIRSGCGGSMCGRCFNSTHTHPPYKAIEKLVKASREPLLPVAAAPVFSVLHPSDDTNAARGGSQTKATWVDAVKLVQCFQPQGQARTYLPSLAWAELLRAIRRLGGSLKEVQMVVDIITNPTCTKHGERHMHDTRIWNAYLASSDWHHALDLFSNQWKHYGVKETAETSAALMESLLRDGEWERSLDVFRRLQGKEGQLITFTSSVFTAAFRALEQQRDWNSFASLLLDSERFLAPLDISHDWELLSKLQAQRKQKGTPRSTDEIELWRTFVNELRGFNNVTKEMQLAISNALLACDPVKQREMQGEVEKRESLITAEELYSIM
Protein: MICOS complex subunit MIC10 (A0A3B3IRY5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU363011}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU363011}.
Interaction partners:
Sequence:
MWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ
Protein: Importin beta-like protein KAP122 (Karyopherin-122) (Pleiotropic drug resistance regulatory protein 6) (P32767)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:10525531, ECO:0000269|PubMed:10617640}.
Interaction partners:
- SUMO-conjugating enzyme UBC9
- GTP-binding nuclear protein GSP1/CNR1
- GTP-binding nuclear protein GSP2/CNR2
- Eukaryotic translation initiation factor 5A-1
- Importin beta-like protein KAP120
- Eukaryotic translation initiation factor 1A
- Importin subunit beta-4
- Importin subunit beta-3
- Importin subunit beta-5
- Nonsense-mediated mRNA decay protein 5
Sequence:
MSSIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQLNTRGENDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDPQLNNAGNENMIKQWNNPINTFIQLMSVQNQNINADQLLLDSINCSLTYEQLSQFVSLSQKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQAVFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQNLIDLMYQSTEGSDGYENAEKILTIFGNVFANDPLLMSYDLRQQIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSELKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQEFFSVRMVDFWLDLSDAYTNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIEEEGESTSVNEFEDFRNAVSDLAQSLWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVLFRIETMCFVLNTILVDMTLSESPWIKNIVDANKFFNQNVISVFQTGFQTSASTKVSQILKLDFVRTSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMVIKTVSTLCETCREELTPYLMHFISFLNTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNGPEEQAKYILQLTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQPTEIIENDALLQRLSEFQSFWSSDPLQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYFLKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLISEFRKELTPQEFDFMFEKILLVYYDAYIINDPDLLQMTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIVAVAKFWTKLINNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQRSDLNSYTDLLRALVAKFPIEAREWLVAVLPQICNNPAGHEKFINKLLITRGSRAAGNVILQWWLDCTTLPNYQG
Protein: Ras association domain-containing protein 10 (Q8BL43)
Organism: Mus musculus (Mouse)
Function: Plays an important role in regulating embryonic neurogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
Interaction partners:
- Ras association domain-containing protein 7
- Ras association domain-containing protein 6
- Ras association domain-containing protein 8
Sequence:
MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRCRQRRGQRRGLTEDPSGQLELPEPPDENDEDDDDAMPPGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWTAWGDEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCLARGAPARPSLALTQEKQRRVVRKAFRKLAKLNRRRQQQPSSPCSSTSSSTASSCSSSARTHESASVERMETLVHLVLSQDHTIRQQVQRLRELDREIDRYEAKVHLDRMRRHGVNYVQDTYLVGAGIDLDGQTPEGEPEDATLEEKGTEPAAPLDSEAQAAALEELARRCDDLVRLQEERAQQEELLERLSAEIQEELNQRWMQRRNEELAAREESLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLSTDLEAVKADLDYSQQQRDIKERELQGLLQSLHTFEQTVVHDGALGSSGPSREPQPQTCAEMWVDQARGLAKSCPGNDEDSDTGLSSMHSQDSDSVPPVCESLV
Protein: Pituitary homeobox 2 (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (Q9W5Z2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality.
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P97474}.
Interaction partners:
- Left-right determination factor.
- Left-right determination factor
- Southpaw.
- T-box transcription factor TBX5-A
- Catenin beta-1
- Zinc finger homeobox 3.
- DAN domain family, member 5.
- T-box transcription factor 3a
- Insulin gene enhancer protein isl-1
- Bone morphogenetic protein 4.
Sequence:
MTSMKDPLSLDHHHHNHHVTGSKHAPLSMASSLQPLQRSVDSKHRLDVHTVSDTSSPESVEKEKGQSKNEDSNDDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPSYTYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQTMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSNPSLNSGVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
Protein: Phosphotransferase (EC 2.7.1.-) (Q53Y25)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Protein: Glutathione S-transferase U3 (AtGSTU3) (EC 2.5.1.18) (GST class-tau member 3) (Glutathione S-transferase 21) (Q9ZW28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase DHAR2
- Glutathione S-transferase DHAR1, mitochondrial
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Glutathione synthetase, chloroplastic
- Glutathione S-transferase DHAR3, chloroplastic
- Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic
- Ubiquinol oxidase 3, mitochondrial
- Glutathione reductase, chloroplastic
- Probable glutathione peroxidase 8
- Probable glutathione peroxidase 5
Sequence:
MAEKEEGVKLIGSWASPFSRRVEMALKLKGVPYDYLDEDYLVVKSPLLLQLNPVYKKVPVLVHNGKILPESQLILEYIDQTWTNNPILPQSPYDKAMARFWAKFVDEQVTMIGLRSLVKSEKRIDVAIEEVQELIMLLENQITGKKLFGGETIGFLDMVVGSMIPFCLARAWEGMGIDMIPEEKFPELNRWIKNLKEIEIVRECIPDREKHIEHMMKIVGRIKAV
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q7JQ37)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MFCFLLVFGVNVVLVHLTTGEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRNEPRLINSMCNSQLSPLSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLETDCLIDVPIKIV
Protein: Zinc finger protein 334 (Q9HCZ1)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MKMKKFQIPVSFQDLTVNFTQEEWQQLDPAQRLLYRDVMLENYSNLVSVGYHVSKPDVIFKLEQGEEPWIVEEFSNQNYPDIDDALEKNKEIQDKHLTQTVFFSNKTLITERENVFGKTLNLGMNSVPSRKMPYKCNPGGNSLKTNSEVIVAKKSKENRKIPDGYSGFGKHEKSHLGMKKYRYNPMRKASNQNENLILHQNIQILKQPFDYNKCGKTFFKRAILITQKGRQTERKPNECNECRKTFSKRSTLIVHQRIHTGEKPYVCSDCRKTFRVKTSLTRHRRIHTGERPYECSECRKTFIDKSALIVHQKIHGGEKSYECNECGKTFFRKSALAEHFRSHTGEKPYECKECGNAFSKKSYLVVHQRTHRGEKPNECKECGKTFFCQSALTAHQRIHTGEKPYECSECEKTFFCQSALNVHRRSHTGEKPYECSQCGKFLCTKSALIAHQITHRGKKSYECNECGKFFCHKSTLTIHQRTHTGEKHGVFNKCGRISIVKSNCSQCKRMNTKENLYECSEHGHAVSKNSHLIVHQRTIWERPYECNECGRTYCRKSALTHHQRTHTGQRPYECNECGKTFCQKFSFVEHQRTHTGEKPYECNECGKSFCHKSAFRVHRRIHTGEKPYECNQCGKTYRRLWTLTEHQKIHTGEKPYECNKCEKTFRHKSNFLLHQKSHKE
Protein: F420H(2)-dependent biliverdin reductase (F-BVR) (EC 1.3.98.-) (P9WLL7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the F420H(2)-dependent reduction of biliverdin-IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection.
Subcellular location: Cell surface {ECO:0000305|PubMed:27364382}. Secreted {ECO:0000305|PubMed:27364382}.
Interaction partners:
- Uncharacterized oxidoreductase Rv2073c
- Precorrin-6A reductase
- Precorrin-4 C
- Precorrin-6Y C
Sequence:
MAMVNTTTRLSDDALAFLSERHLAMLTTLRADNSPHVVAVGFTFDPKTHIARVITTGGSQKAVNADRSGLAVLSQVDGARWLSLEGRAAVNSDIDAVRDAELRYAQRYRTPRPNPRRVVIEVQIERVLGSADLLDRA
Protein: Ectonucleotide pyrophosphatase/phosphodiesterase 1 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1) (Si:ch211-142e24.2 protein) (B0JZL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- 5'-nucleotidase, ecto
- nucleoside diphosphate phosphatase
- NAD kinase b.
- NAD kinase a.
- Nucleoside diphosphate kinase 6
- Adenosine kinase
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase 3
- Nucleoside diphosphate kinase
- Ectonucleoside triphosphate diphosphohydrolase 1
Sequence:
MDSAKRDEHMSEHAANLLGTGQRYTRTHNTAKVQSRYLKILCAVLLLGLLALILTIIFLLKLRCSDKVIDSCKNRCISKSHDGNAGCRCDAACVNEGTCCLDYEEVCLQPTQLWTCSKFRCGEDRLPSSLCSCSADCVKVGDCCANYKRTCEGEKSWLQEDCEDIRTPQCPAGFSKSPLLLVSLDGFRAGYMNAYSALLPAIRKLRECGTSTPYMRPAYPTKTFPNHYTIVTGLYPETHGIVDNKMYDVNRNASFSLKVDEKFNPLWYQGEPVWITAMKNHLKTATFFWPGSDVKVHGRYPDYWIKYNRNILFEKRIAQIFQWLHLPEGERPDFYTLYFEEPDASGHKYGPMSTQVIEALINVDRLIGMLMDGLKERNLHKCVNVVLVSDHGMEEASCKKAAYVSNYLDNINDITVIQGPAARVRPRHVPEEFFSFDYEGLVKNLSCREPNQPMKPYLKEHLPKRLHFAKNIRIERAHLYMQPQWQAALKPSEIKYCRGGFHGSDNVFKNMQAIFIGYGPGIHYNTTVPPFENIEVYNLLCDLLGISPAANNGTHGSLNHILKKPRYQPVFPAERSAPSTCSAVSSSLRDPRGCTCDSLTEAEVNRLNQRLINSNSDSNVKPVHLPFGIPRVLQDQSDYCILHHSSYISGYSRDILMPLWVSYSLNTTVVLHPSAEWCVRADVRVQASDRQSCSIYKNNSSMSFGLLHPPNFSPAGTEPDSLITSNMVPMYPGFKDIWTHFHNFLLIKFSEEMNGINVVSGPIFDNDFDGNYDFMNKGVLNGAPIPTHFFIILTSCKNSSLSVRQCEGPLDAVSFILPHRPDHLETCHNGTDYSWFQDWVQLHVARIRDIELLTGLSFYHDRISVAETLQLKTRLKTF