wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase ppe1 (EC 3.1.3.16) (Phosphatase esp1) (P36614)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12.
Subcellular location: Nucleus {ECO:0000269|PubMed:12773390}. Note=Associated with chromatin.
Interaction partners:
- Uncharacterized protein C63.05
- Extragenic suppressor of kinetochore protein 1
- Serine/threonine-protein phosphatase 2A activator 1
- Separin
- Protein phosphatase PP2A regulatory subunit A
- Protein phosphatase PP2A regulatory subunit B
- Securin
Sequence:
MFDLDEWIATVRKCKYLPEHQLKRLCEMVKVILMEESNIQPVRTPVTVCGDIHGQFYDLLELFRVGGELPSTNYIFMGDFVDRGYFSLETFTLFMLLKARYPDKITLLRGNHESRQITQVYGFYDECQTKYGNANVWKYCCQVFDFLTLAAVIDNKILCVHGGLSPEVRTLDQIRILARAQEIPHEGSFCDLMWSDPEDIESWTVSPRGAGWLFGSKVTTEFSQINDLTLIARAHQLVQEGYKYHFADKNLVTVWSAPNYCYRCGNVASVMKVDESLEPEFRIFSAVADEDRTVPPSRKRSEYFI
Protein: ER membrane protein complex subunit 1 (F4JXW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 6
- Membrane magnesium transporter
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 7 homolog
- ER membrane protein complex subunit-like protein
- ER membrane protein complex subunit 8/9 homolog
Sequence:
MAIRVFLTLLLFLSSAILSFSLYEDQAGLTDWHQRYIGKVKHAVFHTQKTGRKRVIVSTEENVVASLDLRHGEIFWRHVLGTKDAIDGVGIALGKYVITLSSEGSTLRAWNLPDGQMVWETSLHTAQHSKSLLSVPINLKVDKDYPITVFGGGYLHAVSAIDGEVLWKKDFTAEGFEVQRVLQAPGSSIIYVLGFLHSSEAVVYQIDSKSGEVVAQKSTVFPGGFSGEISSVSSDKVVVLDSTRSILVTIGFIDGDISFQKTPISDLVEDSGTAEILSPLLSNMLAVKVNKRTIFVNVGDKGKLEVVDSLSDETAMSDSLPVADDQEAFASVHHEGSRIHLMVKLVNDLNNVLLRETIQMDQNRGRVHKVFMNNYIRTDRSNGFRALIVMEDHSLLLLQQGAIVWSREEGLASVTDVTTAELPLEKDGVSVAKVEHTLFEWLKGHVLKLKGSLLLASPEDVVAIQDLRVKSSGKNKLTRDHNGFRKLILALTRAGKLFALHTGDGRIVWSMLLNSPSQSQSCERPNGVSLYQWQVPHHHAMDENPSVLVVGKCGSDSSAPGVLSFVDVYTGKEISSSDIGHSVVQVMPLPITDSKEQRLHLIADTVGHVHLYPKTSEALSIFQREFQNVYWYTVEADDGIIRGHVMKGSCSGETADEYCFTTRELWTVVFPSESEKIISTLTRKPNEVVHTQAKVNTDQDLLYKYVSRNLLFVATVSPKGAGEIGSVTPEESSLVVYLIDTITGRILHRLSHQGCQGPVHAVFSENWVVYHYFNLRAHKYEVTVVEIYDQSRAENKNVWKLILGKHNLTAPITSYSRPEVFTKSQSYFFAQSVKTIAVTSTAKGITSKQLLIGTIGDQILALDKRFVDPRRTLNPSQAEKEEGIIPLTDTLPIIPQAYVTHSHKVEGLRGIVTAPSKLESTTHVFAYGVDLFYTRLAPSKTYDSLTDDFSYALLLITIVALVAAIYITWVLSEKKELSEKWR
Protein: SKN-1 Dependent Zygotic transcript (Q9XVB9)
Organism: Caenorhabditis elegans
Interaction partners:
- Serpentine Receptor, class H
- Protein containing ALS2cr12
- Coiled-coil domain-containing protein 73
- DUF305 domain-containing protein
- Trichohyalin-like
- IkappaB kinase
- DUF4781 domain-containing protein
- Uncharacterized protein
Sequence:
MVYVNANVDTKVDNRKDNCDNTNTYSHTVDRKDNFDNTTTNTKTVNRNDNCNNQEEGDVNMYRRNDNCNNREATNSRSANYSIHNQGMINCYNGIAIDNRAFNSSGANTMAGTEFLRAFLDAPMSVMPGSRKNAIMDRQEGSTQPAIRYNNR
Protein: Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase) (P05089)
Organism: Homo sapiens (Human)
Function: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16141327}. Cytoplasmic granule {ECO:0000269|PubMed:15546957}. Note=Localized in azurophil granules of neutrophils (PubMed:15546957). {ECO:0000269|PubMed:15546957}.
Interaction partners:
- Ornithine aminotransferase, mitochondrial
- Ornithine transcarbamylase, mitochondrial
- Ornithine decarboxylase
- Antizyme inhibitor 2
- Nitric oxide synthase, inducible
- Argininosuccinate lyase
- Nitric oxide synthase 3
- Nitric oxide synthase 1
- Glycine amidinotransferase, mitochondrial
- Arginase-2, mitochondrial
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
Protein: Transcription factor NIGTH1 (MYB-domain transcription factor NIGT1 homolog 1) (Q5VRW2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor that may play a role in regulatory networks controlling development and metabolism.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
Sequence:
MASSSSDLTLDDHHHLTAVAAASGQATQKLQEFLSRLEEERLKIDAFKRELPLCMQLLNHAMEAYRQQLEAYQMGSQHSAAAAAAARAPLVLEEFIPVKNIGIDVVAADKAAAAGGNSVSSEKASWMVSAQLWNAPASASAADTAAKGPQTPKEHSEHHPLDTSPKLITALDGGGGGGGAFLPFSKDNAMGDGSAAAAAALPELALAPAEKAADAITIAAGEVDKKPYAHDNGVVARSREAQNGGKPPSTPSDGQAVPPPPQPHRKARRCWSPELHRRFVNALQILGGAQVATPKQIRELMKVDGLTNDEVKSHLQKYRLHTRRPMPSPAPPTAATPQLVVLGGIWVPPEYATQAAGPAIYGAHPATQPHYTAAVAAQEYYHHHHHHLQHHPAAAALVHHRAVAPPPPLPPQQQLAPPYSAKSSASARLGSPDSDGRGSGGGGGAAASGAGRDMSESIEEEGEGEEREDDDDDDEMAATNNAHAVDGDDDNDEINTTTTTSAGAINY
Protein: Heat shock 70 kDa protein 4 (Ischemia responsive 94 kDa protein) (O88600)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- STIP1 homology and U-Box containing protein 1, isoform CRA_b.
- Bcl2-associated athanogene 3.
- BAG family molecular chaperone regulator 1
- Toll-like receptor 4
- Toll-like receptor 2
- Heat shock protein beta-8
- Apoptotic protease-activating factor 1
- Hsc70-interacting protein
- Stress-induced-phosphoprotein 1
- DnaJ heat shock protein family
Sequence:
MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKVRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSILDQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQNAKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQQYMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIKELTNICSPIISKPKPKVEPPKEEPKHAEQNGPVDGQGDNPGTQAAEHGADTAVPSDGDKKLPEMDID
Protein: Protein trichome birefringence-like 32 (Q9SRL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable xylan acetyltransferase that plays a role in xylan acetylation and normal deposition of secondary cell walls. Required for 2-O-monoacetylation, 3-O-monoacetylation and 2,3-O-diacetylation of xylosyl residues in xylan. Required for the formation of 3-O-acetylated, 2-O-glucoronic acid-substituted xylosyl residues. May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:26745802}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Protein REDUCED WALL ACETYLATION 2
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 1
- Putative alpha-xylosidase 2
Sequence:
MTTALFSPSNRRKRRLTHFFFTVLAFILLAAFIYGHDFISFSRRSLHSPTIVHQSAIVVVVDEPPPPPPTSPPPPSPPPPSPPPPSPPPPSPPPPAFAVGKTPEGCDVFKGNWVKDWSTRPLYRESECPYIQPQLTCRTHGRPDSDYQSWRWRPDSCSLPSFNATVMLESLRGKKMMFVGDSLNRGMYVSLICLLHSQIPENSKSMDTFGSLTVFSLKDYNATIEFYWAPFLLESNSDNATVHRVSDRIVRKGSINKHGRHWRGADIVVFNTYLWWRTGFKMKILEGSFKDEKKRIVEMESEDAYRMALKTMVKWVKKNMDPLKTRVFFATMSPTHYKGEDWGGEQGKNCYNQTTPIQDMNHWPSDCSKTLMKVIGEELDQRAEFPVTVLNITQLSGYRKDAHTSIYKKQWSPLTKEQLANPASYSDCIHWCLPGLQDTWNELFFAKLFYP
Protein: Proteasome (Prosome, macropain) 26S subunit, ATPase, 1 (Proteasome 26S ATPase subunit 1) (cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA) (Q53XL8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
Protein: Nuclear transcription factor Y subunit C-6 (AtNF-YC-6) (Q9FGP7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear transcription factor Y subunit B-10
- Nuclear transcription factor Y subunit B-4
- Nuclear transcription factor Y subunit B-5
- Nuclear transcription factor Y subunit B-2
- Nuclear transcription factor Y subunit B-7
- Nuclear transcription factor Y subunit B-1
- Nuclear transcription factor Y subunit A-7
- Nuclear transcription factor Y subunit B-3
- Nuclear transcription factor Y subunit B-6
- Nuclear transcription factor Y subunit A-8
Sequence:
MAENNNNNGDNMNNDNHQQPPSYSQLPPMASSNPQLRNYWIEQMETVSDFKNRQLPLARIKKIMKADPDVHMVSAEAPIIFAKACEMFIVDLTMRSWLKAEENKRHTLQKSDISNAVASSFTYDFLLDVVPKDESIATADPGFVAMPHPDGGGVPQYYYPPGVVMGTPMVGSGMYAPSQAWPAAAGDGEDDAEDNGGNGGGN
Protein: Sll1784 protein (P73601)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Sll1305 protein
- Sll1307 protein
- Glucosyltransferase
Sequence:
MKTLRLSPLLSKLCLILLIVLGTLTIAIPKALAISTLDNFPHPNIEKTEKILGPAGEIFEFSTCNADGIGFTIAEAQIPPGAGPLPHIHHYTNEWFWTPKGGLQLFQSVKEYPDLENPATDEQAGNTTVYTVNTEPNQIVYGPKYRVHGFANTTTETRPLTFIWLEDGISPEYELHDGGIREYFQDVGIPIKDLKHLPAITEESKIEFVSHAPLYGINQSYYFFEYVDGVSGKLPTSLTKLENDQSLNRIIDTINAYNQGDATVKCF
Protein: NPP1 domain protein, putative (AFU_orthologue AFUA_5G00600) (Q5B8B9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MVSRTLLASLAASAAAIPLTPNAGLLTRDVIDHDAVVGFDETVPDSKIGDMYLAYKPYLKVVSGCVPFPAVDAEGNTSGGLQPSGGSSDGCDSSTGQVYARSTMTDGTDSTYGPAIMYSWYMPKDEPSTGLGHRHDWEGVIVWLSSSSSTSADNILAVCPSAHGDWNCSTDGFTLTDSTHPLIQYYNVWPVNHQLGLTSTVGGTQPLIAWESLTDAAQNALQTTDFGDATVPFKDSTFSANLGEATY
Protein: Neuroligin-3 (Gliotactin homolog) (Q62889)
Organism: Rattus norvegicus (Rat)
Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Synapse. Note=Detected at both glutamatergic and GABAergic synapses.
Interaction partners:
- Neurexin-2
- Neurexin-3
- Neurexin-1
- SH3 and multiple ankyrin repeat domains protein 3
- Disks large homolog 4
- Receptor-type tyrosine-protein phosphatase delta
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Neuroligin-1
- Neuroligin-2
- SH3 and multiple ankyrin repeat domains protein 1
Sequence:
MWLQLGLPSLSLSPTPTVGRSLCLILWFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPNSHSTTRV
Protein: ATP-dependent DNA helicase MPH1 (EC 3.6.4.12) (FANCM-like protein 1) (Mutator phenotype protein 1) (P40562)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Prevents crossovers between ectopic sequences by removing substrates for MUS81-MMS4 or RAD1-RAD10 cleavage. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable). Binds to flap-structured DNA but not to non-flap nicked DNA, and participates in Okazaki fragment processing by stimulating the endonuclease activities of FEN1 and DNA2. Involved in recombination donor preference during mating-type switching via interaction with FKH1.
Subcellular location: Nucleus {ECO:0000269|PubMed:10880470, ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent helicase SGS1
- ATP-dependent DNA helicase SRS2
- Structural maintenance of chromosomes protein 5
- DNA topoisomerase 3
- Replication factor A protein 1
- DNA repair protein RAD51
- Crossover junction endonuclease MUS81
- DNA repair and recombination protein RAD52
- DNA repair protein RAD5
- Crossover junction endonuclease MMS4
Sequence:
MASADDYFSDFEDDELDKLYEKAINKSVKETITRRAVPVQKDLHDNVLPGQKTVYEEIQRDVSFGPTHHELDYDALSFYVYPTNYEVRDYQYTIVHKSLFQNTLCAIPTGMGKTFIASTVMLNYFRWTKKAKIIFTAPTRPLVAQQIKACLGITGIPSDQTAILLDKSRKNREEIWANKRVFFATPQVVENDLKRGVLDPKDIVCLVIDEAHRATGSSAYTNVVKFIDRFNSSYRLLALTATPASDLEGVQEVVNNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLLEIEDIIEQLGMAVKPVLQQAIELGIYEECDPSQINAFKAMQQSQKIIANPTIPEGIKWRNFFILQLLNNVGQMLKRLKIYGIRTFFNYFQNKCTEFTTKYNLKKSTNKIAAEFYYHPILKNIKNQCENYLSDPKFVGHGKLQCVRDELMDFFQKRGSDSRVIIFTELRESALEIVKFIDSVADDQIRPHIFIGQARAKEGFDEVKYTRKHAPKGRKKVERLHRQEQEKFLEAERTKRAANDKLERSARRTGSSEEAQISGMNQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGEVDLIICYDTTSSPIKNIQRMGRTGRKRDGKIVLLFSSNESYKFERAMEDYSTLQALISKQCIDYKKSDRIIPEDIIPECHETLITINDENEIINEMEDVDEVIRYATQCMMGKKVKPKKAITKKKRVQENKKPKKFFMPDNVETSIVSASTLINKFLVNESGGKQLVTSNENPSKKRKIFKALDNLENDSTEEASSSLETEDEEVSDDNNVFIAEGQNGCQKDLETAIIRTGESLTTLKPLHNFERPNMALFVNDCGLPTKIEKNVKDIRGNQHNLEKEKSCTVDKNNMVLSLDDWNFFRNRYIPEGVSFDVEPNFVQYTKGVKVPHCHKVSKIITLFNDESNDNKKRTIDMNYTKCLARGMLRDEKKFVKVNDKSQVDNNSVNHDSSQSFTLSNAELDDILGSDSDF
Protein: Protein phosphatase eya (EC 3.1.3.48) (Developmental protein eyes absent) (Protein Clift) (Q05201)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:8431945}.
Interaction partners:
- Protein sine oculis
- Dachshund, isoform B
- Protein Optix
- GM13131p
- Shaven, isoform A
- Protein atonal
- Fasciclin-3
- Eyegone, isoform A
- Zinc finger protein 1
- Protein teashirt
Sequence:
MVTLMPYNYAAPRCGLIDKMIEPKVKRPKTDHTDTHERNRLCNLSQQQQQQQPQQQQTHQQQQQQQQQSHQQSHSSTVLASNGPSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQSQPLQPTIGSLASLSGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAAAAYLTPSYAASGNNNSQLYSSPYAGYNNFGQQDYGGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1) (Q9UHI8)
Organism: Homo sapiens (Human)
Function: Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- Furin
- CCN family member 1
- Amphiregulin
Sequence:
MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS
Protein: RH72336p (Vacuolar protein sorting 2) (Q9VBI3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Charged multivesicular body protein 1, isoform A
- GH14561p
- Vacuolar protein sorting 20, isoform A
- Charged multivesicular body protein 4
- Charged multivesicular body protein 5
- vesicle-fusing ATPase
- Vacuolar protein sorting-associated protein VTA1 homolog
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein sorting-associated protein 28 homolog
Sequence:
MDWLFGKKISPDEMLRKNQRALNKAMRDLDRERMKMEQQEKKIIADIKKMAKEGQMDAVKIMAKDLVRTRRYAKKFMLMKANIQAVSLKIQTLKSQNTMAQAMKGVTKAMQNMNRQLNLPQIQKILQDFEKQSEMMDMKEEMINDAIDDAMEDEGDEEETDAVVSQVLDELGLQLGEQLGDLPSASGSLSIAGGAGAQKAQAVAAGGVGGGGAAGGGGASGGGAGGPGAPGGSGASSPMSDADADLQARLDKLRKD
Protein: Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) (Q2YDF6)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11344316, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein mS31
Sequence:
MAAPSLPAWLALQTRARTLRAFSTAVSPVTGAQRLSPPTTERTSKHERAPRRKALPPRTEKMSVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKRGVPMAKEGNLELLKIPNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEIDTADYISSGPSIRNPKARVVTLRVKLSSLNLDDHAKKKLIKLVGDRYCKSTDVLTIKTDRCPLKRQNYDYAMYLLTVLYHESWKTEEWEKKKTEADMEEYVWKDSASEKNILETLFQIKAAEKNTELSKEELLSTKEVEDYKNSVVSLKNEGDNENTISQYKESVKRLLHLM
Protein: Inositol-phosphate phosphatase (EC 3.1.3.25) (L-galactose 1-phosphate phosphatase) (EC 3.1.3.93) (Myo-inositol monophosphatase) (Q9M8S8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphatase acting on L-galactose 1-phosphate (L-Gal 1-P), D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P). Can also use beta-glycerophosphate (glycerol 2-P) and, to a lesser extent, D-galactose 1-phosphate (D-Gal 1-P), alpha-D-glucose 1-phosphate (a-D-Glc 1-P), D-mannitol 1-phosphate and adenosine 2'-monophosphate as substrates. No activity with D-fructose 1-phosphate (D-Fru 1-P), fructose 1,6-bisphosphate (Fru 1,6-bisP), D-glucose 6-phosphate (D-Glc 6-P), D-alpha-glycerophosphate (glycerol 3-P), D-sorbitol 6-phosphate and D-myoinositol 2-phosphate. The C1 phosphate position in a six-member ring substrate is important for catalysis.
Interaction partners:
- L-galactose dehydrogenase
- GDP-L-galactose phosphorylase 2
- Probable inositol 3-phosphate synthase isozyme 3
- GDP-L-galactose phosphorylase 1
- Inositol-3-phosphate synthase isozyme 1
- Inositol-3-phosphate synthase isozyme 2
- Inositol oxygenase 4
- 3'
- Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2
- Inositol oxygenase 2
Sequence:
MADNDSLDQFLAAAIDAAKKAGQIIRKGFYETKHVEHKGQVDLVTETDKGCEELVFNHLKQLFPNHKFIGEETTAAFGVTELTDEPTWIVDPLDGTTNFVHGFPFVCVSIGLTIGKVPVVGVVYNPIMEELFTGVQGKGAFLNGKRIKVSAQSELLTALLVTEAGTKRDKATLDDTTNRINSLLTKVRSLRMSGSCALDLCGVACGRVDIFYELGFGGPWDIAAGIVIVKEAGGLIFDPSGKDLDITSQRIAASNASLKELFAEALRLTGA
Protein: Lysine-specific histone demethylase (EC 1.14.99.66) (F6NIA2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038051}.
Interaction partners:
- REST corepressor 1.
- Histone deacetylase 1
- High-mobility group 20B
- RE1-silencing transcription factor
- PHD finger protein 21Ab.
- Histone H3
- Histone H3.2
- Androgen receptor
- Histone H3.3
- DNA
Sequence:
MLSNKKSDPGSSSSSGGNGGDRAPETLAAPQAGPAGPSGPISADVKKKERASPSGEPGGPPLPHPPGPGGIDQDSAEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKERKQVIPPPAPPIEEENDSEPEEPSGINGVEGAAFQSRLPHDRMTSQEAACFPDIINGPQHTQKVFLYIRNRTLQLWLDNPKVQLTFEATVQQLEAPYNSDAVLVHRIHSYLERHGFINFGIYKRVKPLPTKKTGKVIVIGAGVSGLAAARQLQSFGMDVTVLESRDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKDLLNKMVTTKEKVKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELVEMQVKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTSSGCEVIAVNTRSTTQTFIYKCDAVLCTLPLGVMKQQPPAVQFVPPLPEWKTAAIQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALMAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQPVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTMPRQATANPNPQPSPSIQ
Protein: Acetylserotonin O-methyltransferase 3 (OsASMT3) (EC 2.1.1.4) (Q8VWG4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24134674}.
Interaction partners:
Sequence:
MAQRVQEEDEQMTSTDDLIQAEIELYHHCFAFIKSTALRAATDLCISDAIHRNGGAATLSDLALNIGLHPTKLSHLRRLMRVPTVSGVFAVEDHNGEAMYTLTRVSRLLLNGDGERTHALSHLVRVLVNPLTVASHFSIHEWFTIEQAAAMTPFEVAHGCTRWEIIANDAKDGSVFNTAMVEDSRVAMDIILKESCGVFQGISSLVDVGGGHGAAAAAIATAFPNIKCTVLDLPHIVAEAPTTHSNIQFVGGDFFEFIPAADVVLLKYILHAWQDDDCVKILRRCKEAILARDAGGKVIIIEVVVGIGPKEIVPKEMQILFDVFMMYVDGIEREEHEWKKIFLEAGFSDYKITPVLGARSIIEVYP
Protein: LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3) (Q8TAP4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDYEEGLMKEGYAPQVR