wanglab/gogpt-training-data huggingface dataset:
Protein: RING-box protein 1A (Regulator of cullins 1a) (dRbx1) (Q9W5E1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons. The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1. Also part of an SCF complex required for caspase activation during sperm differentiation (Probable).
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Cullin homolog 1
- Supernumerary limbs, isoform B
- GEO01111p1
- Cullin-2
- Cullin 3, isoform F
- Cullin-4A
- S-phase kinase-associated protein 2
- Cullin-5
- Elongin-C
- Elongin-B
Sequence:
MEVDEDGYEVPSSSSKGDKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWDFQKYGH
Protein: Guanine nucleotide-binding protein subunit beta-like protein (Q57YU9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal protein L24, putative
- Ribosome production factor 2 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- rRNA processing protein, putative
- Ribosome biogenesis protein, putative
- Ribosome assembly factor mrt4
Sequence:
MQSGSEKRNGQKRPRHAGEAAASSPAVSLKQKKLKPKKKTDNAGEGNEDQLQQRRRQQEEKRNLPIASSSPAAAQQVKSPVLDQVQAKVPTEECRSALLVIGTYHSVMAGLLYRRRRFGLLFSIKHHVGCINAVTAGGGAKYMASAGTDERVFLFTNKSHSVQKQLKLLKKKQKRQAKRLKKGGEPCENGGEMEETLAFAGPSAETNSGSSAEPLALRLTDLGHVSPPSEVRCMKITSNSQLMLCGCTDGQLITYRTRDWSINSAIPLHEKCISSIALHPGSNNDGGSGAALAITCSAEDHHIVVVDLLRGRLLSKWRYSTSLATAISRYSANKDNGGRDNVASPAAVQTTSNSDEPGRPVKLAKWERHDEPREVHFSPVGSYFAVLSSHALLVYETATMRAVAHYRAPSPLQPHNEMHTFCFMDEQTIMIGDESGNIRCCCGPWQGACVPGIVERRIPHGSEGGNVGVCGTNNSSGDTTGSFAAGSDASQHSGRHPTKHSTRVKALHCAGRTLFSLDAAGVAIAWNVDKGGISSNNSISASGKSSDLMLHYICSANCRGRVTTMDVLRL
Protein: Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane) (Q8N292)
Organism: Homo sapiens (Human)
Function: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:18559951}; Single-pass membrane protein {ECO:0000269|PubMed:18559951}.
Interaction partners:
Sequence:
MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY
Protein: ZZ-type zinc finger-containing protein 3 (Q8IYH5)
Organism: Homo sapiens (Human)
Function: Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- SAGA-associated factor 29
- Cysteine-rich protein 2-binding protein
- MAP3K12-binding inhibitory protein 1
- Transcriptional adapter 3
- Transcriptional adapter 2-alpha
- YEATS domain-containing protein 2
- WD repeat-containing protein 5
- Histone acetyltransferase KAT2A
- Protein Dr1
- Histone H3.1
Sequence:
MAASRSTRVTRSTVGLNGLDESFCGRTLRNRSIAHPEEISSNSQVRSRSPKKRPEPVPIQKGNNNGRTTDLKQQSTRESWVSPRKRGLSSSEKDNIERQAIENCERRQTEPVSPVLKRIKRCLRSEAPNSSEEDSPIKSDKESVEQRSTVVDNDADFQGTKRACRCLILDDCEKREIKKVNVSEEGPLNSAVVEEITGYLAVNGVDDSDSAVINCDDCQPDGNTKQNSIGSYVLQEKSVAENGDTDTQTSMFLDSRKEDSYIDHKVPCTDSQVQVKLEDHKIVTACLPVEHVNQLTTEPATGPFSETQSSLRDSEEEVDVVGDSSASKEQCKENTNNELDTSLESMPASGEPEPSPVLDCVSAQMMSLSEPQEHRYTLRTSPRRAAPTRGSPTKNSSPYRENGQFEENNLSPNETNATVSDNVSQSPTNPGEISQNEKGICCDSQNNGSEGVSKPPSEARLNIGHLPSAKESASQHITEEEDDDPDVYYFESDHVALKHNKDYQRLLQTIAVLEAQRSQAVQDLESLGRHQREALKNPIGFVEKLQKKADIGLPYPQRVVQLPEIVWDQYTHSLGNFEREFKNRKRHTRRVKLVFDKVGLPARPKSPLDPKKDGESLSYSMLPLSDGPEGSSSRPQMIRGRLCDDTKPETFNQLWTVEEQKKLEQLLIKYPPEEVESRRWQKIADELGNRTAKQVASRVQKYFIKLTKAGIPVPGRTPNLYIYSKKSSTSRRQHPLNKHLFKPSTFMTSHEPPVYMDEDDDRSCFHSHMNTAVEDASDDESIPIMYRNLPEYKELLQFKKLKKQKLQQMQAESGFVQHVGFKCDNCGIEPIQGVRWHCQDCPPEMSLDFCDSCSDCLHETDIHKEDHQLEPIYRSETFLDRDYCVSQGTSYNYLDPNYFPANR
Protein: Menage a trois-like protein 1 cyclin H assembly factor isoform 1 (A0A024R688)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS
Protein: VEGF-receptor C (Q8T4L9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEKTANRCQSP
Protein: GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) (O75140)
Organism: Homo sapiens (Human)
Function: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:28199306}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61460}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P61460}. Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent. {ECO:0000269|PubMed:28199306}.
Interaction partners:
- GATOR2 complex protein MIOS
- KICSTOR complex protein ITFG2
- GATOR1 complex protein NPRL2
- KICSTOR complex protein SZT2
- GATOR2 complex protein WDR24
- KICSTOR subunit 2
- Ras-related GTP-binding protein C
- GATOR1 complex protein NPRL3
- GATOR2 complex protein WDR59
- Ras-related GTP-binding protein A
Sequence:
MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP
Protein: Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) (P57053)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- DNA
- Histone H3.2
- Histone H3.1t
- Histone H3.1
- Histone H3-7
- Histone H3.3
- Histone H4
- Histone H2A type 2-C
- Histone H2A type 2-A
- Histone H3.3C
Sequence:
MPEPAKSAPAPKKGSKKAVTKAQKKDGRKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLPHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
Protein: RH14816p (Q8MT20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGLALGVLIGPPFGGVMYEFVGKSAPFLILAALALGDGLLQLFMLQPSIQKAETEPPSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIDTRRSTAAFTPWVMWPSVLASPWVPPYLDRW
Protein: Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (O13134)
Organism: Ambystoma tigrinum (Eastern tiger salamander)
Function: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:11095641}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6R1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSSEKECLENMLNGYAESGRVLSRTSLVINQAVNRSIFTSTVSPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCIEKGTILLDLEATSLPQIVEIVINNQIELGLLKADMKENVTRTLLRKHRHQTKKSNLRSLADIGKTVSSASRLFSTPDNGSPTMTHRNLTSTSLNDVSDKPDKEQLKNKFMKKLPRDAEASNVLVGEVDFLESPFIAFVRLQQAVMLGSLTEVPVPTRFLFILLGPKGKAKSYHEIGRSIATLMSDEVFHDIAYKAKNREDLIAGIDEFLDEVIVLPLGEWDPTIRIEPPKSLPSSDKRKNMYSGGDNLQMNGDAPHDDGGGGHGDSEELQRTGRFCGGLIKDIQRKAPFFASDFYDALSIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAVSGAVFCLFGGQPLTILSSTGPVLVFERLLFNFSKDNDFDYLEFRLWIGLWSAFQCLILVATDASFLVKYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSHFKVDYITQYSCACFPPEPANSSWFNMTTAATTTQFLTNASTDMAYNGTIDWSLLSKKECLKYGGLLVGSNCKYVPDITLMSFILFLGTYTCSMALKKFKTSRYFPTTARKLISDFAIILSILIFCGLDALLGVDTPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLAAAIPALLVTILIFMDQQITGVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTVVFLLTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPPKYQPDFIYLRHVPLRRVHLFTFLQVVCLAMLWILKSTVAAIIFPVMILALVAVRKAMDYFFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSIDSDVEDSDCPYPEKVPSIKIPMDIMEKEPFLIDSKPSDRENSPTFLERHTSC
Protein: Prickle homolog 1a (Prickle-like protein 1a isoform X1) (F1Q6J9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- Vang-like protein 2
- Vang-like protein
- T-box transcription factor TBX1
- Dishevelled segment polarity protein 2.
- Cadherin EGF LAG seven-pass G-type receptor 1
- Ankyrin repeat domain 6b
- Dishevelled segment polarity protein 1b
- Dishevelled segment polarity protein 3a
- Dishevelled segment polarity protein 3b
- Protein Wnt-11
Sequence:
MELENRGGLHMGSKVNKLTLGFQRSSTSDDDSGCALEEYAWVPPGLRPEQVALYFSCLPEDKVPYVNSPGEKQRIKQLLYQLPPHDNEVRYCQSLSEEEKKELHMFSIQRKKEALGRGTLKILPRTVHHAACEHCGERLGGGEMAVCVSRAAAAGQCWHPACFTCSTCSELLVDLIYFYHDGKVHCGRHHAELLKPRCSSCDEIIFADECTEAEGRHWHMKHFSCSECEVILGGQRYIMKDGRPFCCGCFQSLYAEYCQACAQHIGVDHAQMTYDGLHWHATDACFSCAQCKSSLLGCPFLPRQGRIYCSKACSLGEDVQASDSSDSAFQSARSRESRRSVKMGKSSRSADQCRQSLLFSPASNYKFPGLSGNADDTLSKRLSQLNFADNHFWRNREDQEAPEDHEEWAEHDDYMTQLLLKFGEHGMFQDTRTDLSIWTDSELKNKTGSGGNSSLASKKYKADMYWTQSQDGLGDSAYGSHPGPASSRKLQDLDLEHGASFKHEDNKQWFNDSLECITDQLKEADLNIRDSMDSLALSNITGASVDGDIKDKPLLFSLQKFSDLDRCENTSNMGTLNSSMKSLTSDLDRTQVIEEQQEQGVPSPEVHPKPPRLPVLRRSKSQSKTQQVKFSDDVIDNGRYDELKVRQPPMSERTRRRAFQFDEQDHQRPRHHHRRRRSRMSRSDNALHLAPKEEKPRVCFKDDRRKHGLGHNGAQYGDGLRTERFTRLYEDDWCSTCSSSSSESEEEGFFLGQPIPQPRQPRYQYYASDEAAFGTRTKSKQKRGRKGKNCIIS
Protein: non-specific protein-tyrosine kinase (EC 2.7.10.2) (C9J1X3)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAARRFPGLELSFPLLARLRRRLYTRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (F6NP87)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH:ubiquinone oxidoreductase subunit V3.
- NADH:ubiquinone oxidoreductase core subunit S3
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH:ubiquinone oxidoreductase subunit B10.
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
Sequence:
MAAVTLICRPAGVLPKLSGTCSPVLLAAAPVTVQQRKIHHAVVPRGKGGRSSISGLAATVFGATGFLGRYVVNRLGRMGSQVVIPYRCDQYDLMYLRPMGDLGQIIFMEWDPRNKESIQRAISHSNVVINLVGREWETSNYKYEDVFVSIPLQIARATREAGIKKFIHMSHLNADIRSPSKYLRNKAVGEEAVRNEFPDAIIMKPSELFGREDRFLNHFANMRWFGTAVPLIAMGKKTVKQPVHVVDVAKAIINAIQDPEANGKTYALVGPNRYLLHDLVEYLYSVAHRPFMPYPLPRPLYHLVARFFEMNPFEPWTTRDKVDRLHTSDLKYPDLPGLEDLGITPASIEQKAIETLRRHRRQRFFEAAVGEAKPSKTVNF
Protein: Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (A0A8I6G4Y3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGNKIVI
Protein: General control transcription factor GCN4 (Amino acid biosynthesis regulatory protein) (General control protein GCN4) (P03069)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Master transcriptional regulator that mediates the response to amino acid starvation. Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions. During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors. Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:12455686, ECO:0000269|PubMed:14648200}. Note=Localizes to the nucleus independently of cellular amino acid levels. {ECO:0000269|PubMed:12455686}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 15
- Eukaryotic translation initiation factor 2 subunit alpha
- CRE-binding bZIP protein SKO1
- Cyclin-dependent protein kinase PHO85
- PHO85 cyclin-5
- eIF-2-alpha kinase GCN2
- Regulatory protein LEU3
- Lysine biosynthesis regulatory protein LYS14
- Myb-like DNA-binding protein BAS1
- SAGA complex/transcription factor TFIID complex subunit TAF12
Sequence:
MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIFDKFIKTEEDPIIKQDTPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDSTPMFEYENLEDNSKEWTSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFLPTPVLEDAKLTQTRKVKKPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVPESSDPAALKRARNTEAARRSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER
Protein: Retinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (P32) (Q27979)
Organism: Bos taurus (Bovine)
Function: Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9914166}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:9914166}. Microsome membrane {ECO:0000269|PubMed:7836368}.
Interaction partners:
- Retinoid isomerohydrolase
- Lecithin retinol acyltransferase
- Aldehyde dehydrogenase 1A1
- Retinol dehydrogenase 10
- Aldehyde dehydrogenase 1A1
- NADP-retinol dehydrogenase
- Retinol dehydrogenase 12
- Retinaldehyde-binding protein 1
- Diacylglycerol O-acyltransferase 1
- Aldehyde dehydrogenase 1 family member A2
Sequence:
MWLPLLLGVLLWAALWLLRDRQCLPASDAFIFITGCDSGFGRLLALRLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDVTDPQSIRQAVKWVETHVGEAGLFGLVNNAGVAGIIGPTPWQTREDFQRVLNVNTLGPIGVTLALLPLLLQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAPFGVRVSIVEPGFFRTPVTNLETLEDTLQACWARLPPATQALYGEAFLTKYLRVQQRIMNMICDPDLAKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPARLVDAVLAWVLPKPAQTVY
Protein: XH/XS domain-containing protein (Q9M150)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein SUPPRESSOR OF GENE SILENCING 3
Sequence:
MKKKQQKQEFVAETSEMNNNNECSGQDQQKRYVWPWVGLVANVPTEVEPSGRRVGKSGSTLRDEFTLKGFNPTRVKPIWNTKGHTGFALVEFAKDFKGFESAMQFEKSFDLDRHGKRDWKKGHRLRDDKLYGWLAREDDYNRSDTVGKNVKKKRDLKSISQIVEEDQRKLYHLFENMCQTIEKNKQRKQQLEQKVDETLESLEFHNLMLNNSYQEEIQKMEKNMQEFYQQVLGGHEKSFAELEAKREKLDERARLIEQRAIKNEEEMEKTRLEREMIQKAMCEQNEANEEAMKLAEKHQKEKEKLHKRIMEMEAKLNETQELELEIEKLKGTTNVMKHMVGCDGDKDIVEKIAKTQIELDARETALHEKMMTLARKERATNDEYQDARKEMIKVWKANEELMKQEKIRVKIMGELNPAPFLPAVMNKHKAMMLCSVWAAEIGDVQWTPFRVDESDGTPKQKLHISQHSKCEMQRVVDENDEKLRMLKNQYGEEVYSEVVRAKLEMEEHNASGSYETEELWNYEENRKATIEEITDVMLKIRSKLAAMKNKRKRP
Protein: ABC transporter G family member 12 (ABC transporter ABCG.12) (AtABCG12) (Protein ECERIFERUM 5) (White-brown complex homolog protein 12) (AtWBC12) (Q9C8K2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the secretion of cuticular wax from epidermal cells to the cuticle, especially in the transport of aldehydes, alcohols and acids.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15499022, ECO:0000269|PubMed:20870961}; Multi-pass membrane protein {ECO:0000269|PubMed:15499022}. Endoplasmic reticulum {ECO:0000269|PubMed:20870961}. Note=Trafficking to the plasma membrane is dependent of ABCG11. {ECO:0000269|PubMed:20870961}.
Interaction partners:
- 3-ketoacyl-CoA synthase 6
- Fatty acyl-CoA reductase 3
- Non-specific lipid transfer protein GPI-anchored 1
- Non-specific lipid transfer protein GPI-anchored 2
- Protein ECERIFERUM 2
- Exosome complex component RRP45B
- Alkane hydroxylase MAH1
- Cytochrome P450 86A2
- 3-ketoacyl-CoA synthase 1
- Long chain acyl-CoA synthetase 1
Sequence:
MELESTSNGRRPPPPAEIGRGAYLAWEDLTVVIPNFSGGPTRRLLDGLNGHAEPGRIMAIMGPSGSGKSTLLDSLAGRLARNVIMTGNLLLNGKKARLDYGLVAYVTQEDILMGTLTVRETITYSAHLRLSSDLTKEEVNDIVEGTIIELGLQDCADRVIGNWHSRGVSGGERKRVSVALEILTRPQILFLDEPTSGLDSASAFFVIQALRNIARDGGRTVVSSIHQPSSEVFALFDDLFLLSSGETVYFGESKFAVEFFAEAGFPCPKKRNPSDHFLRCINSDFDTVTATLKGSQRIRETPATSDPLMNLATSEIKARLVENYRRSVYAKSAKSRIRELASIEGHHGMEVRKGSEATWFKQLRTLTKRSFVNMCRDIGYYWSRIVIYIVVSFCVGTIFYDVGHSYTSILARVSCGGFITGFMTFMSIGGFPSFIEEMKVFYKERLSGYYGVSVYIISNYVSSFPFLVAIALITGSITYNMVKFRPGVSHWAFFCLNIFFSVSVIESLMMVVASLVPNFLMGLITGAGIIGIIMMTSGFFRLLPDLPKVFWRYPISFMSYGSWAIQGAYKNDFLGLEFDPMFAGEPKMTGEQVINKIFGVQVTHSKWWDLSAIVLILVCYRILFFIVLKLKERAEPALKAIQAKRTMKSLKKRPSFKKVPSLSSLSSRRHQPLHSLSSQEGLTSPIN
Protein: Protein cornichon homolog 3 (CNIH-3) (Cornichon family AMPA receptor auxiliary protein 3) (Q6ZWS4)
Organism: Mus musculus (Mouse)
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
Interaction partners:
- Glutamate receptor 2
- Glutamate receptor 1
- Glutamate receptor 3
- Glutamate receptor 4
- Voltage-dependent calcium channel gamma-8 subunit
- Protein shisa-9
- Leucine-rich repeat transmembrane neuronal protein 4
- Protein shisa-6
- Voltage-dependent calcium channel gamma-3 subunit
- Voltage-dependent calcium channel gamma-2 subunit
Sequence:
MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQCNPVHARERLRNIERICFLLRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHFWRYFHCPADSSELAYDPPVVMNADTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS
Protein: Calcium channel, voltage-dependent, alpha 1I subunit (F7BQ85)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XPRMPTSSPGAPGRGSGGAGVGGDTESHLCRHCYSPAQDSLEGELTIIDNLSGSIFHHYSSPAGCDKCHHDKQEVQLAETEAFSLNSDRSSSVLLGDDLSLEDPT