wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease 2) (F4JNY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro. By contrast, another report show that APE2 has no biochemical activity. Unable to catalyze the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH. Has no in vitro 3'-phosphatase activity. Redundant with APE1L and at least one functional allele is required for seed viability. Has a strong non-specific affinity to DNA.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00764}.
Interaction partners:
- Adenine DNA glycosylase
- Flap endonuclease 1
- DNA polymerase delta small subunit
- N-glycosylase/DNA lyase OGG1
- Uracil-DNA glycosylase, mitochondrial
- Polynucleotide 3'-phosphatase ZDP
- Formamidopyrimidine-DNA glycosylase
- Endonuclease III homolog 2, chloroplastic
- Exonuclease 1
- DNA-repair protein XRCC1
Sequence:
MKIVTYNVNGLRQRVSQFDSLLKLLDSFDADIICFQETKLRRQELTADLAIADGYESFFSCTRTSEKGRTGYSGVATFCRVKSASSSCETALPVTAEEGITGLVNSNSRGGKSETSTVAEGLEEYEKEELLMIDQEGRCVITDHGHFVVFNVYGPRAVADDADRIEFKHRFYGVLERRWECLLRQGRRVFVVGDLNIAPFAMDRCEAGPDFEKNEFRKWFRSLLVERGGSFSDVFRSKHPERKDAFTCWSSSSGAEQFNYGSRIDHILVAGSCLHQDEDKQGHSFLACHVKECDILTEYKRFKNENMPTRWKGGLVTKFKGSDHVPVFISFDDLPDIPEHSTPPLASRYLPMIYGFQQTLVSVFKKRRANEEAKAIEVSCSSSTQSNTSSICGDISTGPLRNCGSMGISLEKSCSFENKSTSGVTEAETVAATGSIDNLSDGIRASSVRALNISRDGDRKKARKIQSSQLSLKSFFTTNSKVNNVEDSSSSYVSSSPSSQVESITEPNVSGKEDSEPTTSTQEQDQTGSSAKQKNDAALMEWQRIQNLMQNSIPLCKGHKEACVARVVKKPGPTFGRRFYVCSRAEKQTVVISNGLHQNSETSKRVMRSK
Protein: Chaperone ric-8 (Resistance to inhibitors of cholinesterase protein 8) (Synembryn) (Q9GSX9)
Organism: Caenorhabditis elegans
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors. While it acts as a GEF for goa-1, it has no GEF activity toward gpa-16. In addition to its GEF activity, it is required for cortical subcellular localization of G-alpha proteins such as gpa-16. Also required for the interaction of goa-1 and gpr-1/2, suggesting that it may act by generating G-alpha proteins free from G-beta-gamma subunits, enabling gpr-1/2 to mediate asymmetric cell division.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:15479638, ECO:0000269|PubMed:15479639, ECO:0000269|PubMed:9851916}. Note=Localizes to the cell cortex. Excluded from interphase nuclei and becomes localized around what appeared to be kinetochore microtubules at the onset of mitosis, becoming more diffuse during anaphase.
Interaction partners:
- Guanine nucleotide-binding protein alpha-16 subunit
- Guanine nucleotide-binding protein G
- Probable delta-1-pyrroline-5-carboxylate synthase
- Guanine nucleotide-binding protein subunit alpha
- Regulator of G-protein signaling rgs-7
- Mss4 protein
- Guanine nucleotide-binding protein subunit beta-1
- Protein let-99
- Regulator of G-protein signaling egl-10
- Guanine nucleotide-binding protein G
Sequence:
MSEELHSDLIASIFGGKPAKIEEFFSKWNFANAAVSKFDMANSAKNELGDRICEVIENGELTHVLLETIKILSREKDGLEGLLNDPLCDKILAFAELSSNENNSKTVHTLMEAQKCLINTLFHSQRMRDRFYANPKTGENLQFFLGEFEENRRKTSSIDWIRLLNPVQAAEIWYFYHRIAFIATALGREFQKNWANDPKTIDSLLLAVEICTNRSENSTQDINRATEALKTFFNVFCHFHGDVKAIDHKNAAKTCQILRDAICSDVLTDDVVQSAIHCLSVPPLPMVLSVLCGKNSKNNGGENEEEKFFVEELSNMQLTEAILMHLDKQLTKVVALLLNDAPNQQQNPMLSAEASTLTDLVGPYFQVLARLCTDSKYVRRYCRIRVIPPLVSEEVQKRPEENNTLRGRIARIMMLPSSTKDVAAEFLFIICKRSVNRMIKYLGFGHSAGHLANLGLLGQINQPKHASDSEDSETEDYNQIKDSVNPVTGAIYPSDHGSALAGMSEEQKEYEAMKLVDAMNQMMETGIVKPGTIGDDGKIREVSHVLELLKNAPEPAPAENSDSDEE
Protein: La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) (Q92615)
Organism: Homo sapiens (Human)
Function: Stimulates mRNA translation.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20573744}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment. {ECO:0000269|PubMed:20573744}.
Interaction partners:
- Polyadenylate-binding protein 1
- ATP-binding cassette sub-family F member 1
- Large ribosomal subunit protein eL31
- ATP-dependent RNA helicase A
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS28
Sequence:
MTSDQDAKVVAEPQTQRVQEGKDSAHLMNGPISQTTSQTSSIPPLSQVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGHHADRGPQGSDANGDGDQGHENAALPDPQESDPADMNALALGPSEYDSLPENSETGGNESQPDSQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDVSLYAQQRYATSFYFPPMYSPQQQFPLYSLITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAGPGRVEPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSPSPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATELRKPSYAEICQRTSKEPPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGAPRDQRRPAGGRPSPSAMGKRLSREQSTPPKSPQ
Protein: Signal recognition particle receptor FtsY (SRP receptor) (EC 3.6.5.4) (A0A0H2UQF6)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00920}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_00920}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_00920}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00920}.
Interaction partners:
Sequence:
MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVDPTFTEVEEVSQEEAEVEIVEQAVFQEEEIQDTVEESQDSEPAVGVSQEEIEELPNSEELPEEEKLEHEGTVEENNSEVLEPEAPQTEETVQEKYDRSLKKTRTGFGARLNAFFANFRSVDEEFFEELEELLIMSDVGVQVASNLTEELRYEAKLENAKKPDVLRRVIIEKLVELYEKDGSYDESIHFQDNLTVMLFVGVNGVGKTTSIGKLAHRYKQAGKKVMLVAADTFRAGAVAQLAEWGRRVDVPVVTGPEKADPASVVFDGMERAVTEGIDILMIDTAGRLQNKDNLMAELEKIGRIIKRVVPEAPHETFLALDASTGQNALVQAKEFSKITPLTGIVLTKIDGTARGGVVLAIREELNIPVKLIGFGEKIDDIGEFNSENFMKGLLEGLI
Protein: Synaptopodin 2-like b (Synaptopodin 2-like protein) (U3JAM7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVAEEVVVTLSGGAPWGFRLQGGAEHQKPLQVAKVRKRSKACRAGLRETDELLSINDVSCGSLSHAEAMNLIDSGRGTLHLRIKRAPAPYQSVVLVGRAPSPRIDKEYRAALRALSPPLSSKPSGVNRASLMSPTGLEWLTSPPDSEAYYGETDSDADVAAQERQRRQKRRSPSTSPAKIPGQTSPQEEETSGLSGYESTQDVMYPQTQSWPVPDVEGMGTLQKQVMHGVARREVVFQPQQNEWSQQGENSSENSDQSPSGAAEVDSGFQEPPTVPPPLVSPERAKEALMLASHRQMVPMVGPVDNPVDEELTVTYMDKARQAKLHRGESLQDKQVKEARSKCRTIASLLTDAPNPHSKGVLMFKKRRQRAKKYTLTCFGSVDGESNSNTEGETEDESLFPGSESELDEDGFSAAPDPTWDSGYLDVLDKRTSACIVPDREAEISPGLNATSGKGAQLFEQQRKRAEEHVSNLNTFSMPQHQGDSTLTYTPVAPYTPQSTSSLSTSMVNGEPLVVSRTSVVLSSPGQTPMPSLTGALPEQIDSSAASSVHNRTARPFAPGCVSNRAATAPVVFRPSPAKKAGSQSQAVSVATLPAAFSPVVSEGKKAISTSSLYIPARPATYNGPSSLLSPSSVISSPFSPPPSNAPLYSPTYSSTSAPFSPTTSHVTSLSLPSGMAQTYSQPQAMPFSPPHPTVSSQFQPPPPVNVPAQPFSSSFMNAPGFPNVPVHPPTSLNMQPSPSHKVSFNPYISVASTTPETPNAPIAQQYPLSNSTDGISSREQRLSVPAGRTGILQEACRRSTKKPMFSAQEEKKAPSFNPELLSLVQNFDDRSRSGVEAGFESGPEEDFLNLGAEACNFMQAQKNRLPPPVAPKPGHPAPEMPQMRGKGAELFARRQSRMDRYVVDKQPKSPAQPRDPSPTPSLPGNWKYSPNIRAPPPINYNPLLSPSCPLVAQRSTKANDATKVGVKTMHGHNKQGIKALDFVSKQPYQLNPSLFSYGANPQNNTTCQQQQQNGVGITGQFLNPPKQVPIKAGRVYEIKRFSTPTPMSAPTSLTPTVIAPRSATTLGEPMWRSDVTSPPPVAPRPAAPFSPPPPAPTAALPALPKISSAANSGPITQPNQGQAYTPFQTAKQFKSAPELSPLSAGVRSSGSASGLNLRVPRPRFCTSSMGLQPNVWRPGSIHY
Protein: CaDmium Responsive (Q18832)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MISSCAIKVVFILSVIGIIIYKKFFKKPSIRAKPEPYKKDYNRGTVYLYQFKRTKKCPNLSPFCMKVEVLCRAYKVPYEICDEKLIWSRNGTLPFIELNGEHIADTDLIEVRLREHFNISSLPKEKEAQSVAITRLADNHLFNVLLRYKTSDNDFYYTLLGNMGVPKILQPICLPFIKAAFVKKAYERSTRAIGDFEQTDLDDILHRDLQTIQDYLGEQKFLFGDEVKAADAAVFGQLATVIYPFRCKINDILENDFPQLLEYCERVRKEIYPNDFVE
Protein: Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1) (Q9Y5J5)
Organism: Homo sapiens (Human)
Function: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
Interaction partners:
Sequence:
MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS
Protein: Extracelllular iron oxide respiratory system periplasmic decaheme cytochrome c component MtrA (Q8EG35)
Organism: Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Interaction partners:
- Extracellular iron oxide respiratory system surface decaheme cytochrome c component MtrC
- Extracellular iron oxide respiratory system outer membrane component MtrB
- Extracelllular iron oxide respiratory system surface decaheme cytochrome c component OmcA
- Tetraheme c-type cytochrome CymA
- Extracellular respiratory system surface decaheme cytochrome c component MtrF
- Fumarate reductase
- Aromatic amino acid permease
- Extracellular respiratory sytem outer membrane component MtrE
- Cytochrome c-552
- Outer membrane beta barrel protein
Sequence:
MKNCLKMKNLLPALTITMAMSAVMALVVTPNAYASKWDEKMTPEQVEATLDKKFAEGNYSPKGADSCLMCHKKSEKVMDLFKGVHGAIDSSKSPMAGLQCEACHGPLGQHNKGGNEPMITFGKQSTLSADKQNSVCMSCHQDDKRMSWNGGHHDNADVACASCHQVHVAKDPVLSKNTEMEVCTSCHTKQKADMNKRSSHPLKWAQMTCSDCHNPHGSMTDSDLNKPSVNDTCYSCHAEKRGPKLWEHAPVTENCVTCHNPHGSVNDGMLKTRAPQLCQQCHASDGHASNAYLGNTGLGSNVGDNAFTGGRSCLNCHSQVHGSNHPSGKLLQR
Protein: Thioredoxin domain-containing protein (Thioredoxin-like protein DPY-11) (G5EC91)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
- Prolyl 4-hydroxylase subunit alpha-1
- Cuticle collagen dpy-5
- Homeobox protein unc-42
- Actin-depolymerizing factor 1, isoforms a/b
- UNC-76
Sequence:
MLLRLLAVLGLFAVGVSGGPTRSSKLVFLNEENWTDLMKGEWMIEFHAPWCPACKDLQKAWNAFADWSDDLGIKVGEVDVTVNPGLSGRFLVTALPTIYHVKDGVFRQYSGARDKNDFISFVEDKKYRVIDPVPDYKHPNSKQMAVVAVFFKLSMSVRDLHNHLVEDKGIPSWASYGLFAGVTLALGCVLGFFIVIIIDQVFPTGPRKSQQAKKTEKKDAKKDSGTESPTKKNGNNNNGKETKKTK
Protein: F8L10.9 protein (Protein kinase superfamily protein) (Q9LNN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein NETWORKED 2D
- NADP-dependent malic enzyme 4, chloroplastic
- Protein DA1-related 4
- Protein EXPORTIN 1A
- Hypersensitive-induced response protein 1
- Cytochrome c oxidase subunit 5b-2, mitochondrial
Sequence:
MGCVCGKPSAIEDSKDSPRERFSSKSSSEFRVSRPVASSRREEPLRIKERSDVVSVRPVLSNKQSNVSLHLRGENLSRREKRIENVAATSPLAMSITIAKATEGEYVAAGWPPWLASVAGEAIRGWVPRRADSFEKLDKIGQGTYSNVYRARDLDQKKIVALKKVRFDNLEPESVRFMAREIQILRRLDHPNIIKLEGLVTSRMSCSLYLVFEYMEHDLAGLASHPAIKFSESQVKCYLQQLLHGLDHCHSRGVLHRDIKGSNLLIDNSGVLKIADFGLASFFDPRQTQPLTSRVVTLWYRPPELLLGATRYGAAVDLWSAGCILAELYAGKPIMPGRTEVEQLHKIFKLCGSPTEDYWVKSRLPHATIFKPTQPYKRLVGETFKEFPQPALALLETLLSVNPDDRGTATAALKSEFFSTRPLPCDPSSLPKYPPSKELDARMRDEESRRQVGGNRDQRHQERRGTKESRAIPAPDANAELVASMQKRQSQSTNRSRSEKFNPHPEEVASGFPIDPPRPSSQAFEPNRESQGNIIPHKRASHSGPLSRRSASAKGRRNYQDSQKVSSIADYSAMPGFAATRTGAPQQETCRGMTRLPGSFKETSEEANQEENGRSNKKDPILLGYGSKGHKIHYSGPLVVPSGNMDQVLKDHDRHIQEAVRRARIDKARVKKLQADEASSQQVATNHPSSVSSR
Protein: Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) (Q9UNL2)
Organism: Homo sapiens (Human)
Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Translocon-associated protein subunit delta
- Translocon-associated protein subunit beta
- Translocon-associated protein subunit alpha
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit alpha isoform 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Protein transport protein Sec61 subunit gamma
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Sequence:
MAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK
Protein: Ubiquitin-like modifier-activating enzyme 1 Y (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) (Ubiquitin-activating enzyme E1 Y) (P31254)
Organism: Mus musculus (Mouse)
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like modifier-activating enzyme 7
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-conjugating enzyme E2 S
- Ubiquitin-conjugating enzyme E2 N
- Histone demethylase UTY demethylase UTY)
- Ubiquitin-conjugating enzyme E2 C
Sequence:
MSSSVLSKKRKVSGPDSSLDSSWSPTYSVMFGVPPGPTNEMSKNKEMDIDESLYSRQLYVLGHEAMKHLQASSVLISGLQGLGVEIAKNIILGGVKAVTLHDQGIAQWADLSSQFCLREEDIGKNRAEISQPRLAELNSYVPVFAYTGPLIEEFLSGFQVVVLTNTPLEYQLQVGEFCHSHGIKLVVADTRGLVGQLFCDFGEEMILTDSNGEQPLSAMVSMITKENPGIVTCLEDSRHGFESGDFISFTEVQGMSELNGIGPIEIKVLGPYTFSICDTSSFSEYIRGGIVSQVKVPRKINFKPLLASLAEPEFVVTDFAKCCHPAQLHIGFQALHQFCTQHSRPPRPHNEEDAEELVTLAQSVNAQALPAVQQDCLDIDLIRKLAYVAAGDLAPMNAFFGGLAAQEVMKACSGKFMPIRQWLYFDALECLPEHRVAFMEDKCLPHQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEDGEITVTDMDTIEKSNLNRQFLFRPWDITKLKSETAAAAVRDINPHIRIFSHQNRVGPETEHVYDDDFFQKLDGVANALDNVDARLYVDRRCVYYRKPLLESGTLGTKGNVQVVVPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTVQWARDEFEGLFKQSAENVNQYLTDPKFMERTLQLAGTQPLEVLEAIHCSLVLQRPQTWADCVTWAYQHWHTQYSHNIQQLLHNFPPAQLTSSGALFWSGPKRCPHPLTFDINNPLHLDYVMAAANLFAQTYGLGGSQDCAVVAKLLQSLPVPKFAPKSGIRIHVSEQELQSTSATTIDDSHLEELKTALPTPDKLLGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYGISPADRHKSKLIAGKIIPAIATTTSAIVGLVCLELYKVVQGHQQLESYKNSFINLALPLFSFSAPLAPECHQYYDQEWTLWDRFDVQGLQPSGEEMTLKQFLDYFKTEHKLEVIMLSQGVSMLYSVFMPASKLKERLDQPMTEIVSCVSKQKLGHHVKSLVFELCCNSDSGDDIEVPYVRYIIR
Protein: Transmembrane and coiled-coil domains protein 1 (O94876)
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to contact sites between the endoplasmic reticulum and endosomes that are spatially and temporally linked to endosome fission. {ECO:0000269|PubMed:30220460}.
Interaction partners:
- Podocalyxin-like protein 2
- Cilia- and flagella-associated protein 100
- Krueppel-like factor 15
- Plexin-D1
Sequence:
MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR
Protein: Glandular kallikrein KLK13 (Kallikrein l) (Kallikrein related-peptidase 13) (Q8CGR6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Serine protease inhibitor Kazal-type 6
Sequence:
MWPLVATIACLTLALSEGISRDYPKILNGTNGTSGFLPGGYTCLPHSQPWQAALLIRGRLLCGGVLVHPKWVLTAAHCRKDGYTVHLGKHALGRVENGEQAMEVVRSIPHPEYQVTPTHLNHDHDIMLLELKSPVQLSSHVRTLKLSADDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECRQVYPGKITANMLCAGTKEGGKDSCEGDSGGPLICNGKLYGIISWGDFPCGQPNRPGVYTRVSKYLRWIREIIRNTPEQRWTKGTQ
Protein: alcohol dehydrogenase (EC 1.1.1.1) (G8BGN6)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- S-
- Pyruvate decarboxylase
- Aldehyde dehydrogenase domain-containing protein
- Pyruvate decarboxylase
- Aldehyde dehydrogenase domain-containing protein
- MADS-box domain-containing protein
Sequence:
MPIGSTHFFHFKSFIRSIAVNKVTTIPIKAFTTTTTKTKTKITTTTTTNSFISTMPEIPKTQKAVVFETSGGKLEYKDIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVGMGDNVKGWEIGDYAGIKWLNGSCLNCEFCEQGAEPNCPQADLSGYTHDGSFEQYATADAVQAARIPKNADLAKAAPILCAGVTVYKALKTAQLKAGEWVCISGAGGGLGSLAIQYAIAMGYRVIGIDGGAEKGEYIKSLGAEAYIDFTKEKDIVEAVKKATNGGPHGVINVSVSEKAINQSVEYVRPLGKVVLVGLPAGSKVVAPVFDAVVKSVEIKGSYVGNRKDTQEALDFFARGKVNCQIKIVGLSELPEVFKLMEEGKILGRYVLDTSK
Protein: Zinc finger protein 660 (Q6AZW8)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MRRKTRNFKHKTVKDNKVLTEGSDQESEKDNSQCCDPATNERVQAEKRQYVCTECGKAFSQSANLTVHERIHTGEKPYKCKECGKAFSHSSNLVVHRRIHTGLKPYTCSECGKSFSGKSHLIRHQGIHSGEKTYECKECGKAFSRSSGLISHHRVHTGEKPYSCIECGKAFSRSSNLTQHQRMHRGKKVYKCKECGKTCGSNTKIMDHQRIHTGEKPYECDECGKTFILRKTLNEHQRLHRREKPYKCNECGKAFTSNRNLVDHQRVHTGEKPYKCNECGKTFRQTSQVILHLRTHTKEKPYKCSECGKAYRYSSQLIQHQRKHNEEKETS
Protein: Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) (Q9Y4W2)
Organism: Homo sapiens (Human)
Function: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20647540}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:A2BE28}. Cytoplasm {ECO:0000250|UniProtKB:A2BE28}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250|UniProtKB:A2BE28}.
Interaction partners:
- Polynucleotide 5'-hydroxyl-kinase NOL9
- Proline-, glutamic acid- and leucine-rich protein 1
- Testis-expressed protein 10
- Sentrin-specific protease 3
- WD repeat-containing protein 18
- WD repeat-containing protein 5
- Transcription initiation factor TFIID subunit 1
- Microspherule protein 1
- Chromodomain-helicase-DNA-binding protein 8
- Histone-lysine N-methyltransferase 2A
Sequence:
MSWESGAGPGLGSQGMDLVWSAWYGKCVKGKGSLPLSAHGIVVAWLSRAEWDQVTVYLFCDDHKLQRYALNRITVWRSRSGNELPLAVASTADLIRCKLLDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKVPLKCLAQEVNIPDWIVDLRHELTHKKMPHINDCRRGCYFVLDWLQKTYWCRQLENSLRETWELEEFREGIEEEDQEEDKNIVVDDITEQKPEPQDDGKSTESDVKADGDSKGSEEVDSHCKKALSHKELYERARELLVSYEEEQFTVLEKFRYLPKAIKAWNNPSPRVECVLAELKGVTCENREAVLDAFLDDGFLVPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLNDVLVPKPFSQFWQPLLRGLHSQNFTQALLERMLSELPALGISGIRPTYILRWTVELIVANTKTGRNARRFSAGQWEARRGWRLFNCSASLDWPRMVESCLGSPCWASPQLLRIIFKAMGQGLPDEEQEKLLRICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVKPASSSFGSEAKAQQQEEQGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEEDEDDEDDEEEDRMEVGPFSTGQESPTAENARLLAQKRGALQGSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYLLDQPVLEQRLEPSTCKTDTLGLSCGVGSGNCSNSSSSNFEGLLWSQGQLHGLKTGLQLF
Protein: Hermes, isoform A (Hermes, isoform B) (RE60337p) (Q7JWI7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform C
Sequence:
MHKEKIINSQNASKINQKDHKPNGNTNESRHKTVSLINKKDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSVVSATDLIGRIGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAWTYSSVCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLTLLAGASLWSFMPWINRRKANAEEQLDAQIEKAAVDSY
Protein: Novel Thioesterase superfamily domain and Saposin A-type domain containing protein (0610012H03Rik) (Thioesterase superfamily member 7) (Q9DCP4)
Organism: Mus musculus (Mouse)
Interaction partners:
- Fatty acid synthase
- Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Sequence:
MAMRRLLRNICLPWNHRNSDAAITMIPWAWRLLPRNAARSVSTSSANQRAEDPHRQLEAYGYFLPIQTRWQDNDQNSHVNNAVYYSYFDTVISHYLIRYCGLKTSLLTSPQVGFMVTNQCKFHTPISFPQTPLAALAVEKVGRSSVCYRLALFPPKPTKELPSVNHHDLIDGLFAGHPKLAQFDTLACTTGSSVHVFVNPATNKPENLPEDFRRGLQKLMSPA