wanglab/gogpt-training-data huggingface dataset:
Protein: Photosystem II reaction center protein Z (PSII-Z) (P56790)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00644}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00644}.
Interaction partners:
- Photosystem II protein D1
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein M
- Photosystem II reaction center protein H
- Photosystem II CP47 reaction center protein
- Cytochrome b559 subunit beta
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II reaction center protein L
- Photosystem II reaction center protein I
Sequence:
MTIAFQLAVFALIITSSILLISVPVVFASPDGWSSNKNVVFSGTSLWIGLVFLVGILNSLIS
Protein: Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Q61072)
Organism: Mus musculus (Mouse)
Function: Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25795784, ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Sorting nexin-9
- Protein kinase C and casein kinase II substrate protein 3
Sequence:
MGPRALSPLASLRLRWLLACGLLGPVLEAGRPDLEQTVHLSSYEIITPWRLTRERREALGPSSQQISYVIQAQGKQHIIHLERNTDLLPNDFVVYTYDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLRCGVSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGSCLLNIPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLKSFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFSGSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDTKGYGGSVDSGPTYNAKSTALRDGLLVFFFLIVPLVAAAIFLFIKRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGGPGVSRPPGGPGVSRPPGGPGVSRPPPGHGNRFPVPTYAAKQPAQFPSRPPPPQPKISSQGNLIPARPAPAPPLYSSLT
Protein: Zinc finger protein 592 (Q92610)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Integrator complex subunit 5
- Integrator complex subunit 6
- Integrator complex subunit 3
- MYND-type zinc finger-containing chromatin reader ZMYND8
- Zinc finger protein 687
- Bromodomain-containing protein 3
- Bromodomain-containing protein 4
- Spectrin beta chain, non-erythrocytic 2
- MAU2 chromatid cohesion factor homolog
- Lysine-specific demethylase 5C
Sequence:
MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPSGRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV
Protein: Acetylcholine receptor subunit beta (P09690)
Organism: Mus musculus (Mouse)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Acetylcholine receptor subunit alpha
- Acetylcholine receptor subunit delta
- Neuronal acetylcholine receptor subunit alpha-4
- Acetylcholine receptor subunit gamma
- 43 kDa receptor-associated protein of the synapse
- Neuronal acetylcholine receptor subunit alpha-6
- Neuronal acetylcholine receptor subunit beta-2
- Syntaxin-binding protein 5
- Neuronal acetylcholine receptor subunit alpha-9
- Neuronal acetylcholine receptor subunit alpha-2
Sequence:
MALGALLLLLGVLGTPLAPGARGSEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLIQLPGDQRGGKEGHHEEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRPKPERDQLPEPHHSLSPRSGWGRGTDEYFIRKPPSDFLFPKLNRFQPESSAPDLRRFIDGPTRAVGLPQELREVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDATYHLPPPEPFP
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Somatomedin) (P07455)
Organism: Bos taurus (Bovine)
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05017}.
Interaction partners:
- Insulin-like growth factor 1 receptor
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor-binding protein 5
- Insulin-like growth factor-binding protein 1
- Tyrosine-protein kinase receptor
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor-binding protein 6
- Insulin
- Cation-independent mannose-6-phosphate receptor
- Hepatocyte growth factor
Sequence:
MGKISSLPTQLFKCCFCDFLKQVKMPITSSSHLFYLALCLLAFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKEVHLKNTSRGSAGNKNYRM
Protein: Putative voltage-and cyclic nucleotide-gated ion channel (Q9Y1J9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPALSAVAARQQQLLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSESSIAEPVQTIREGLPRPRSGEFRALFEGNTP
Protein: Surface-associated interspersed protein 4.2 (SURFIN 4.2) (Q8IFM2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MLFVVELDSRLEKSADKRISVERFRKIFEIYVEDKLEELKRSGSEKYDKDCRDFNYFIDDVKDVFINNDLVKIPVKVRKSIWETHVDKNLPKLMKNTTSCKCIRKEHNYNKEYRDMTRTLEDFCEEKTRKLEIIYQKDYDESLYVNFNEWINKKKEDILKEYEKLSNKDKYKHLLKISETCDLNHVDKLFLNISSEDMKKMKEDVKKQHLEVKVRPPVNEPIDDRGKEDALSRGGKSIILNKEENSPTEEITTEYNPVSEMGVGTTIAHSEPGPKTVNTEVRNVLRSDGKISDQGSQKSPPKELSNKQMTPAQRKNVPHFVERRGYGNSHVRGNALKKISNGDDNYKSPSSNYIEVDCAEDKYFLLEDGTNQSENSCKTKYNYFVSNDYDGTGSAIYSTDQVPSREEIKSPDSLSTLDARGSTHNLNVSNEGNPLEGGEEKNNVKISEQNGRNLESSVGTDKGSDKNEEEVAATCDPNDRNCFDGRYINVDYIRGLLKGKRSGSDGRSNIKHIISNNFDDSNMIFPTFNFDFDILKAEEEVLPVNNSDIIYGHEEVEETTQEGASIFEKHSHTSSQQNDSSASGNKYRMLSTTMELPNQQEVFGLYSPVSRTLDSAMSFLRSIISLSSAPVSRSEGQSKESKRVEISTTVQDPIGYRTSPLQMNAHSVGAGINVSSILSMLGLSSGQVRRSGGQGSETYIVGTSQSGFHKNEVIPSIKDKSGKTQIVSNEKGGIFSKGITSMMSSLPVALVTFVFLFMFLVFNKMNPFGTTIVQGKKKKKVKQKLGERKKPKRRSAKRRRGVDVNMEEEINKIIYTNEFNNYEDKIYEDVKYIKEQENEMYLRDGIEELHMDEPSGDVYFDDQDDYIFLDEQKEDVCLDEAKNDILSKESFDDVLIKVVDREINREINGKINGEINREINGEINGEMNREINREINGEINGKINREINREINGEIPLKKEKWMWKTILEIEMKVVEKCKKEEWEESKGDFLEICLDEFIKKENEYNKIHNKVIIEKSVLENQNMLWNKWIERHRYMLEKWKKEEWFYNLKNEWINEIENYEKKESDIEIILPSEKKTRNISLEKQKIIWRRWVARYVQHIDDDIIEEWFKKMMAEYEKEEYYLNKNRYKIINHIRNRNDKHDENVQCDDEESLVSSSICFDVEEKKKKNLLTKIWFQIHMMILEEYKKDECIHIKNLLLDNYIDNLKKKNELDAKKKLQKLDILNEMKKENNIIDINERNKWEGEKWFEDLNNEWNDYERTYIKNNFVIKKENDMNIKYEYIIIDEPLMKVKKDIPQMHWKNIYEKWLHDEYKYVYRCEDINKSVDEKRDNNIDIGESINVKNNEVMKEKKVKWKTIIEIYMEVMNEYKKDEWEEHRGDFLQICLEEFIKKDNDEMRNINDELYIEQSDHMEDMLMLERQKIRWLQWINRNKYMLEKWNKEEWFCKLKKDWEDEKNRYDEKLFLWKNTENDKYINPMLERQKYIWRKWIAKHLYHIDEWENEEWFKLLMSTYEKDRDDLKRDHPINKMDDMEKKKLITKLFIEIHMMVIEDFKKEECYRNKQTFVDTYINEMKKEEPCEKNREMLNILNNIKKDIKLGYENTKMNEWKEEKWFDKLKKEWKEGECKNFVDIEKENFDKTQVNVINNYMLEIQRSLLKKYWQDVEISWIDDDNQTDWLKIAIHMDDYDNKNKVYNRRHDYMRNKNLHVKKKKNIINEDHLSEDNKYLHENNHSYIKRIIEIYMERVNKIQKKEWEENKRDFLKIALAEYIKMQFDKQKNLCIEEMVIKNKNINDDNNGYLEPAFLWNQWVERKRYIMEKWKYEKWFEELKIEWVKEQGIYIKEEEINTFMKDEKKENNKIIHNDKIIHNDKIIHNDKIIHNNKIINNNNDILIESEKIVWRRWLKKQEQNIQIYKNKKWFKDIIVEFEKDEEDDMIMYSNVNDISKVNNKEVDVNNRDNLIMKIWICICMMILEECKKDEGRYNKEIFLNSFIKEIKKEKDEKIKMNMLDMILQMKEKYISKNEKDFYIYDWKKEKWFEDLKNDCKNNKNEYIYMLQNDLCKRYWKDLDKMWLENEDKIKRNMLTNIYEEYNNMDDLSKKEYIHKNINIINENMKCNSEVEKTHGEHTVEGIKNYYLEKQKEIWRQWIEKNVKHINQSTKEQEQILVDTENNKIVNSSDCKKNENKNEPYYMKKKNLKTVFLAEIHMETMDRCKGLNYKGEDKIETDENIKELKIEEGENSKTNYIHKTILPKDECKKSKLSLNEENKMCKHKNMKENKINDLDNSIYTNLYDDTNKFFFFNENCEGVKSIYQEIEENVEKRYTDDIYLLENEKHHNEFNTHMGENNYDVKEKMDDRNNKNCYMRSYIKPRDKKKNTENKT
Protein: Cullin-like protein 5 (Q9SZ75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA damage-binding protein 1a
- DNA damage-binding protein 1b
- Light-mediated development protein DET1
- RING-box protein 1a
- DET1- and DDB1-associated protein 1
- Cullin-associated NEDD8-dissociated protein 1
- Transducin/WD40 repeat-like superfamily protein
- Cullin-4
- DDB1- and CUL4-associated factor homolog 1
- WD repeat-containing protein ATCSA-1
Sequence:
MKRSISPDPFSSTKSPKLVHHSPDDGGAEGNPYRLPFTLSDENLSCLPISQAREPPPIFNLDPNSVKDTQDRNKLYLAKAWDLLKPAIKIILDDDEYKKPGDVLCFTTIFRAVKRACLGDPRQSELVFNLVKHECEPHIAELIQSLEKNCSGSDDPSVFLPHVYNRWLDFKRKMSLVSDVAMYQTLNGLTLWDVGQKLFHKQLSMAPQLQDQVITGILRLITDERLGKAANNTSDLLKNLMDMFRMQWQCTYVYKDPFLDSTSKFYAEEAEQVLQRSDISHYLKYVERTFLAEEEKCDKHYFFFSSSRSRLMKVLKSQLLEAHSSFLEEGFMLLMDESLIDDLRRMYRLFSMVDSEDYIDRILRAYILAKGEGARQEGSLQELHTSIDKIWHQCFGQDDLLDKTIRDCFEGFGLHVPGEFSDQLQWIDDDDDED
Protein: Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) (O95402)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Protein: Beta-synuclein (Q16143)
Organism: Homo sapiens (Human)
Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Subcellular location: Cytoplasm.
Interaction partners:
- Alpha-synuclein
- Metal regulatory transcription factor 1
- Synphilin-1
- Ubiquitin carboxyl-terminal hydrolase isozyme L1
- Microtubule-associated protein tau
Sequence:
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA
Protein: Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) (Q96M11)
Organism: Homo sapiens (Human)
Function: Plays a role in ciliogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15843405}. Cell projection, cilium {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
Interaction partners:
- ATP-dependent RNA helicase DDX25
- Homeobox protein PKNOX2
- Centrosomal P4.1-associated protein
Sequence:
MEELLPDGQIWANMDPEERMLAAATAFTHICAGQGEGDVRREAQSIQYDPYSKASVAPGKRPALPVQLQYPHVESNVPSETVSEASQRLRKPVMKRKVLRRKPDGEVLVTDESIISESESGTENDQDLWDLRQRLMNVQFQEDKESSFDVSQKFNLPHEYQGISQDQLICSLQREGMGSPAYEQDLIVASRPKSFILPKLDQLSRNRGKTDRVARYFEYKRDWDSIRLPGEDHRKELRWGVREQMLCRAEPQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVIPRKLPFPLSPS
Protein: Caveolin (H2L2G6)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|RuleBase:RU000680}. Membrane, caveola {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|RuleBase:RU000680}.
Interaction partners:
Sequence:
MNNHVQLNFEDIFGEADSQHSWDCVWRLNHTVFTAVRLFIYRLVSLLALPFTIIFAIFFGLLASINVFIIVPLGKLLSIPGTLLAKLWNWLIHAIFDPIASAVGLIFSNFNIRKYGINQETTAPCV
Protein: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) (Q9H4Z3)
Organism: Homo sapiens (Human)
Function: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally.
Subcellular location: Nucleus {ECO:0000269|PubMed:12565871, ECO:0000269|PubMed:18294453, ECO:0000269|PubMed:31279659}.
Interaction partners:
Sequence:
MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT
Protein: Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Fatty acid activator 4) (Fatty acyl-CoA synthetase) (FACS) (Long-chain acyl-CoA synthetase 4) (P47912)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration. Contributes, with FAA1, to the activation of imported myristate. Also involved in long-chain base (LCB) uptake. In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in LCB uptake. Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the shingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:21820081, ECO:0000269|PubMed:24868093}.
Interaction partners:
- Fatty acid synthase subunit alpha reductase
- Long-chain-fatty-acid--CoA ligase 1
- Fatty acid synthase subunit beta dehydratase; Enoyl-[acyl-carrier-protein] reductase; [Acyl-carrier-protein] acetyltransferase; [Acyl-carrier-protein] malonyltransferase; S-acyl fatty acid synthase thioesterase]
- Very long-chain fatty acid transport protein
- Acyl-CoA desaturase 1
- Acyl-coenzyme A oxidase
- Long-chain-fatty-acid--CoA ligase 2
- Triacylglycerol lipase 3
- Monoglyceride lipase
- Diacylglycerol O-acyltransferase 1
Sequence:
MTEQYSVAVGEAANEHETAPRRNIRVKDQPLIRPINSSASTLYEFALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDKPIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMSQGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPSDKRQNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHFPKPEDPACIMYTSGSTGTPKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANVKTLTPTSTRNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERNIPCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLIGYGLTEGVANACVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNNQGELLFKGAPICSEYYKNPEETAAAFTDDGWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYADENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIELLCGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVYKENT
Protein: TMDC IV protein (P70535)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MLSLTWGMKLVERSVVPRVLLLLFALWLLLLVPVRCSEGHPTWRYISSEVVIPRKEIYHSKGIQTQGRLSYSLRFRGQRHIIHLRRKTLIWPRHLLLTTQDDQGALQMDYPFFPVDCYYFGYLEGIPQSMVTVNTCYGGLEGIMMLDDLAYEIKPLNDSQGFEHIVSQIVSEPDVTGPTNTWKRLNLNTGPPLSRTEYANGTPRMSSKNYASHPAAIKGQFQATNSIYKESNNIDTAARYLFELLSITDSFLITIHMRYYAILLTVFTESDPFALEYTVPGGSIYNYYVSNFFNRLRPDASTVLNKDGPSDNDFHPVEQSLCTPAGLTIVGQHRRSFLALSVMITNRIAMSLGIKADDETYCICHRRTTCIMYKNPEITDAFSNCSLVQINQILNTPGTMSCLFYDHHVYHNITKTYRFCGNFKIDIGEQCDCGSHKACYADPCCGSNCKLTAGSICDKELCCANCTYSPSGTLCRPIQNICDLPEYCSGNNIFCPADTYLQDGTPCSEEGYCYKGNCTDRSVQCKEIFGMNAKGANIKCYDINKQRFRFGHCTRAQESLMFNACSDHDKLCGRLQCTNVTNLPFLQEHVSFHQSVISGFTCFGLDEHRGTETTDAGLVKHGTPCSQTNFCDRGACNGSLSRLDYDCTPEKCNFRGVCNNHRHCHCHLGWKPPLCREEGPSGSTDSGSPPKERRTIKQSREPLLYLRMLFGRLYLFIVSLLFGVATRAGVIKVFKFEDLQAALRAAQAKAT
Protein: Uncharacterized protein, isoform B (Uncharacterized protein, isoform C) (Q8IPV2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI20203p1
- Uncharacterized protein, isoform B
- Uncharacterized protein, isoform A
- RE58433p
- RRM domain-containing protein
- Galectin
- Putative tRNA pseudouridine synthase Pus10
Sequence:
MGVDKLPEIRALSEVVEPHVSGSRLLNYHTSSLTKPGDNYGSVLLAIHARLQKSNGESFEEQLVAKVPPIDPKYWQFFQPEQTCLTENAVYKILAPALATLQDEAGVPDESQFKGFPRFYGCRESLESNSSKVDQNAVLVLENLRSSGYVSGQRLKAFDLAHTLLALKYMAEFHALSLALRILRPEVFREQVRPFFKKFDWHAEAPEWKSVMKAETLEDIRRATNNDSRLVARMKELSDQFFEFLAAAPDRPDGPFTSIIHCDFWINNIMFRYGPTGTPVELKIIDFQTAQYDSVVHDIISFLLSSVDTAILEVEFEHMLEAYYEAFERCLRRVGAKLEVHTFKEFRLEVKRVAYIQVPHAIFMTRFILADSALIGDSEAEERPKLTDVLKNTGSERISRKLSQILNLAEKFDILY