wanglab/gogpt-training-data huggingface dataset:
Protein: Major DNA-binding protein (P03227)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.
Subcellular location: Virion tegument {ECO:0000269|PubMed:15534216}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04007, ECO:0000269|PubMed:15731235}. Note=In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments). {ECO:0000255|HAMAP-Rule:MF_04007}.
Interaction partners:
Sequence:
MQGAQTSEDNLGSQSQPGPCGYIYFYPLATYPLREVATLGTGYAGHRCLTVPLLCGITVEPGFSINVKALHRRPDPNCGLLRATSYHRDIYVFHNAHMVPPIFEGPGLEALCGETREVFGYDAYSALPRESSKPGDFFPEGLDPSAYLGAVAITEAFKERLYSGNLVAIPSLKQEVAVGQSASVRVPLYDKEVFPEGVPQLRQFYNSDLSRCMHEALYTGLAQALRVRRVGKLVELLEKQSLQDQAKVAKVAPLKEFPASTISHPDSGALMIVDSAACELAVSYAPAMLEASHETPASLNYDSWPLFADCEGPEARVAALHRYNASLAPHVSTQIFATNSVLYVSGVSKSTGQGKESLFNSFYMTHGLGTLQEGTWDPCRRPCFSGWGGPDVTGTNGPGNYAVEHLVYAASFSPNLLARYAYYLQFCQGQKSSLTPVPETGSYVAGAAASPMCSLCEGRAPAVCLNTLFFRLRDRFPPVMSTQRRDPYVISGASGSYNETDFLGNFLNFIDKEDDGQRPDDEPRYTYWQLNQNLLERLSRLGIDAEGKLEKEPHGPRDFVKMFKDVDAAVDAEVVQFMNSMAKNNITYKDLVKSCYHVMQYSCNPFAQPACPIFTQLFYRSLLTILQDISLPICMCYENDNPGLGQSPPEWLKGHYQTLCTNFRSLAIDKGVLTAKEAKVVHGEPTCDLPDLDAALQGRVYGRRLPVRMSKVLMLCPRNIKIKNRVVFTGENAALQNSFIKSTTRRENYIINGPYMKFLNTYHKTLFPDTKLSSLYLWHNFSRRRSVPVPSGASAEEYSDLALFVDGGSRAHEESNVIDVVPGNLVTYAKQRLNNAILKACGQTQFYISLIQGLVPRTQSVPARDYPHVLGTRAVESAAAYAEATSSLTATTVVCAATDCLSQVCKARPVVTLPVTINKYTGVNGNNQIFQAGNLGYFMGRGVDRNLLQAPGAGLRKQAGGSSMRKKFVFATPTLGLTVKRRTQAATTYEIENIRAGLEAIISQKQEEDCVFDVVCNLVDAMGEACASLTRDDAEYLLGRFSVLADSVLETLATIASSGIEWTAEAARDFLEGVWGGPGAAQDNFISVAEPVSTASQASAGLLLGGGGQGSGGRRKRRLATVLPGLEV
Protein: Long-chain-fatty-acid--CoA ligase (Q9VKU1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGWIFAVLVALVALLLTKPGWRWFYIAGATASRDLTALWAYIKLLRYTKRHERLNYTVADVFERNVQAHPDKVAVVSETQRWTFRQVNEHANKVANVLQAQGYKKGDVVALLLENRAEYVATWLGLSKIGVITPLINTNLRGPSLLHSITVAHCSALIYGEDFLEAVTDVAKDLPANLTLFQFNNENNNSETEKNIPQAKNLNALLTTASYEKPNKTQVNHHDKLVYIYTSGTTGLPKAAVISHSRYLFIAAGIHYTMGFQEEDIFYTPLPLYHTAGGIMCMGQSVLFGSTVSIRKKFSASNYFADCAKYNATIGQYIGEMARYILATKPSEYDQKHRVRLVFGNGLRPQIWPQFVQRFNIAKVGEFYGATEGNANIMNHDNTVGAIGFVSRILPKIYPISIIRADPDTGEPIRDRNGLCQLCAPNEPGVFIGKIVKGNPSREFLGYVDEKASAKKIVKDVFKHGDMAFISGDLLVADEKGYLYFKDRTGDTFRWKGENVSTSEVEAQVSNVAGYKDTVVYGVTIPHTEGRAGMAAIYDPERELDLDVFAASLAKVLPAYARPQIIRLLTKVDLTGTFKLRKVDLQKEGYDPNAIKDALYYQTSKGRYELLTPQVYDQVQRNEIRF
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) (C8VTT9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate acyltransferase Sct1, putative
- Glycerol-3-phosphate dehydrogenase [NAD
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Vacuolar protein sorting protein Vps66, putative
- Patatin-like phospholipase domain-containing protein
- Dihydroxyacetone kinase
- PAP2 domain protein
- PAP2 domain protein
- MBOAT family protein, putative
Sequence:
MRLCQLLRSRANPVIPRLRPSQQFRSIQIIRNSLPRSTSLKLSGPSCLRPPSKSISSYYPTTTTAANNMGSLGPYKQKHKVTVVGSGNWGTAIAKIVAENTASNPAVFEKDVQMWVFEEKVEIPKSSKHYDPASSLCQGPQNLTDIINHTHENIKYLPGITLPENLIANPSLVDAVQDSTILVFNLPHQFIINICEQIKGKIVPYARGISCIKGVDVNEEGVHLFSETIGKILGIYCGALSGANIANEVAQEKWSESSIGYDPPHFDSKAPSPPNRSPSASTDNILHFEHKDVSGQLSRVKLQALPSEFPPIDHALLKSLFHRPYFHIGVVSDVAGVSLGGALKNVVAVAAGWVVGKGWGDNAKAAIMRVGLLEMVKFGEQFFGATINTRTFTEESAGVADLITSCSGGRNFRCAKLSIERNQPIEKIEETELNGQKLQGTLTAVEVNSFLKKQGLEEEFPLFTAVYRVLQGTMSVDEIPSFIER
Protein: Centrosome-associated protein Alms1a (Alstrom syndrome protein 1 homolog a) (Q5BI31)
Organism: Drosophila melanogaster (Fruit fly)
Function: In asymmetrically dividing germline stem cells (GSCs), plays a critical role in ensuring centrosome duplication, which is essential for the production of centrosomes and centrioles in all downstream germ cells. Might recruit SAK for daughter centriole duplication.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32965218}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:32965218}. Note=In male germline stem cells, gonialblasts and spermatogonia, localizes to the proximal end of the mother centrioles (PubMed:32965218). Only in male germ stem cells (GSCs), localizes asymmetrically to the mother centrosomes and within it with higher levels at both mother and daughter centrioles (PubMed:32965218). Colocalizes with SAK at the mother centrosome in GSCs (PubMed:32965218). {ECO:0000269|PubMed:32965218}.
Interaction partners:
Sequence:
MRAKRGAVGKVMMSGSRHNKLAESSRVPPLAREYISAMATDRELDRFMALSSTASSGASGSTHSCALGSVPPPGCASMEHESRPESGHRRRTKSSDHRSPDERGEAKEQLRELSVSPPPSKHKISQFTSPKSEVTKTKPNEYTIIPIVLASSPSFRSVAVTQTMSQSAEDIRTPTKSPQMQNKKTQTPESVLKSHKRLEWDPSADVGYCKRAMSMSNISTLERSVLEDCSWRQPTQQRPEANLDGVQPLLAEEPSPMLDKPTPPLACSTFVNRSERTKSLNSGMESSLSSNKGDPRKKCQRKSRRQDSEVSSCQTDCRSSSQKESTQGSSEAKDIRGNFTTEGTQCSYNRNDTEIDSIMEEEESIDRRKKDDLRISSRVQDPQISSRRPSVSSSRRESLSSYRRDDSRLNSPNSSRLGSEVSSRVESSRSSSRRESQTNSVYGSLSASSFDYHMHMAQEVEVLKHNQRRQQEMEVEPKKQLEKEQHQNDMQQGEPKGRELKDKNHHSGREQQEIQPLMRDQRKAEQRHEKDHQLEREQQGIQQLSKGQRKAKKREKEREQERQYTAAQFEKIRSNRRHVNKENQKPENPVVNPSTGVTASTSTTSLDVGSGSRPGGELDLGIDLLCSLVKSRSLSQGQKKKLVRDIARRISCLELTESSTSSRSLSSSSKEQLKVPTGSLQQVAATNTNQSNARSSSKAERIAPPVPAPRKRAAIGSSSPLPESVSYSGSTSGSGEVITQKTNIPNRNASTDADIEPLDLQDWLNPMTLSEIEFEERLKGGTDSERRRQLHWVKTEINRMQEFKNLLENISLPSKSQKKANTESATAAQIPSSMRCMGDQKERPDKEYLLRQEMSAEAESKEMENSETTTTPPPPVRIESVGVNVTNSDPSTLPAPPPTQPPPPPPHLNQRNLQNRKKMATPLLVSGSSTSGGGRSESVCSFVQQRQRQFREHYQNQQQQQFVLLQQQKLYQLQKQLNQQKDILIQRQQHCGQCAQCGHQRTCIHQQNCPRRQQEAEEQPDEREQYMQMQYAQAAGSAYATPHQSGSSGADKNEAIYYQVVNSQGVASYVQATMVSTETQNEASATGGAGGSAITRSTTTTTNSSSSMMCISSDMSVPMGMMNTCETTTTTTTHQYDDVACQRVRRGHKETTMNAESMQRQTLQVRPRAISYVIQFTPTGSSEVIEKPPSLQDQLQLARPEFCANAKQRKAILNEMQMIRNARRQELDNVLSQSTSMEALNRHLEQLPPPANTRVRLFTTREMKAITSKRCKNLPEVLAAQSRQEEEQRRRSNRLMRDVFNKRLKSRVASGQISLNHSMAIM
Protein: PDZ domain-containing protein 11 (Q9CZG9)
Organism: Mus musculus (Mouse)
Function: Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q5EBL8}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cell membrane {ECO:0000269|PubMed:30463011}.
Interaction partners:
- Sodium-dependent multivitamin transporter
- Copper-transporting ATPase 1
- Afadin
- Tetraspanin-33
- Pleckstrin homology domain-containing family A member 7
- Copper transport protein ATOX1
- Disintegrin and metalloproteinase domain-containing protein 10
- ADP/ATP translocase 2
- ADP/ATP translocase 1
- ADP/ATP translocase 4
Sequence:
MDNRIPYDDYPVVFLPAYENPPAWIPPHERVYHPDYNNELTQFLPRIVTLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
Protein: Transcription factor Sox-11-A (xSox-11) (XLS13A) (Q91731)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor that binds to the DNA sequence 5'-AACAAT-3'. Acts as a transcriptional activator (By similarity). Plays a role together with nlk in neural induction during early embryogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
Sequence:
MVQRADMDSSQHTEPSTDTEEGEFMACSPVSLDESDPDWCKTATGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLNDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKVDPSASSKPPALTQSPEKSPKSRSAGRKCPKLKPSHSGSGSKSLSIKSEYSGGSDEYVFGSPKASGKAAAAAVKCVFMDEDEEEEEEEEDDEEEEDELQIRIKQEEDDEPLRQYNVAKVPASPTLSSSSAESVEGASMYEDIRNGTRLYYNFKNITKQSTIPQATITLAPRPAPTTTSPAASHELLFDLSLNFTQQNPQLPDPNSGNVSLSLVDKDLDSCSEGSLGSHFDFPDYCTPELSEMIAGDWLEANFSDLVFTY
Protein: Inner membrane ABC transporter permease protein YcjP (P77716)
Organism: Escherichia coli (strain K12)
Function: Probably part of the binding-protein-dependent transport system YcjNOP. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane ABC transporter permease protein YcjO
- Putative ABC transporter periplasmic-binding protein YcjN
- D-glucoside 3-dehydrogenase
- D-guloside 3-dehydrogenase
- 3-dehydro-D-guloside 4-epimerase
- Kojibiose phosphorylase
- Glucosylglycerate phosphorylase
- sn-glycerol-3-phosphate transport system permease protein UgpA
- sn-glycerol-3-phosphate import ATP-binding protein UgpC
- Maltose/maltodextrin import ATP-binding protein MalK
Sequence:
MATNKRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKEAISLHPTLLPQQWTLEHYVDIFNPMIFPFVDYFRNSLVVSVVSSVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPDYIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG
Protein: GH23228p (Q8SZT5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMQLAQDAAGPVSQDSASEDGFSAAIASAIASLDNDSAGNTPKRASSMSEDETVANGLNHSLKRRLPGSFSSTGEESDNPPESSGEKRARSGQELPVPVAVPVAASAAASN
Protein: GATA transcription factor 8 (Q9SV30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- GDSL esterase/lipase At1g29670
- Disease resistance protein
- Actin cross-linking protein
- Ribosomal protein L19 family protein
- GATA transcription factor 28
Sequence:
MIGTSFPEDLDCGNFFDNMDDLMDFPGGDIDVGFGIGDSDSFPTIWTTHHDTWPAASDPLFSSNTNSDSSPELYVPFEDIVKVERPPSFVEETLVEKKEDSFSTNTDSSSSHSQFRSSSPVSVLESSSSSSQTTNTTSLVLPGKHGRPRTKRPRPPVQDKDRVKDNVCGGDSRLIIRIPKQFLSDHNKMINKKKKKKAKITSSSSSSGIDLEVNGNNVDSYSSEQYPLRKCMHCEVTKTPQWRLGPMGPKTLCNACGVRYKSGRLFPEYRPAASPTFTPALHSNSHKKVAEMRNKRCSDGSYITEENDLQGLIPNNAYIGVD
Protein: Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (NKCC1) (Na-K-CL symporter) (P55013)
Organism: Squalus acanthias (Spiny dogfish)
Function: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.
Subcellular location: Basolateral cell membrane {ECO:0000305|PubMed:8134373}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEPAFPASSAGVQSQSGPEPGAGQQEPPPPATPLRPVASQSRFQVDLVTEGGGGGDGQKGQTAAQPAAAAKDKDRGDGGAAAPSPASPAAAAEPPAAAAEEAKGRFRVNFVDPASDEPPLSSQQQPPPPSSASSAHGGHQPPSESMNGYPQNGDTMMSEGSLHSSGTGAHHYYDTHTNTYYLRTFGHNTIDAVPRIDHYRHTVAQLGEKLIRPSLAELHDELDKEPFEDGYVNGEESSPAEEAVSKHVADNKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGHAGIGLALLVIGTATVVTTITGLSTSAITTNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVRDLLVEHNALMIDEMSDIRIIGSVTIVVLFGISVAGMEWEAKAQIVLLGILLLAIVNFTVGTFIPANDKRAKGFFNYRGEIFSENFVPDFRDGEDFFSVFAIFFPAATGILAGANISGDLADPQLAIPKGTLLAILITTIVYAGAAVSVGSCIVREATGNLTDAIIPGTVTNCTNVACKLGFNFSSCATNKCSYGLMNDFQVMSLVSGFGPLITAGIFSATLSSALASLVSAPKIFQALCKDNIYPGLHVFSVGYGKNNEPLRGYVLTFFIGLGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFRFYNMWISLIGAILCCGVMFVINWWAALLTNVIVLALYIYVTYKKPDVNWGSSTQALTYLNALQHAIRLTGVEDHVKNFRPQCLLMTGAPTSRPALLHLVHAFTKNVGLVVCGHVHTGPRRQALKEISTDQAKYQRWLIKNKMKAFYAPVYAEDLREGTQFLLQAVGLGRMRPNTLVFGFKKDWRQALMKDVENYINAIHDAFDYQYGVVVIRLKEGFNISHLQAQEELCTSQEKSAHPKDIVVNLEHSDADSSKPSSKSVSETNSPAVCQDQKDEEDDGKASTQPLLKKEVKDPSVPLNMTDQKLLQASSQFQKKQGKGTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRTMATLLSKFRIDFSDITVLGDMNTKPSKDNITAFEEMIEPFRLHEDDKEQEASEKMKEEEPWRITDNELEIYRMKTYRQIRLNELLRENSGTANLIVMSLPVARKGAVSSALYMAWIETLSKDLPPILLVRGNHQSVLTFYS
Protein: glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39) (G8BGZ3)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MKFSTATLIAVLSSIVNASCSYDGGNYYCSETKKVVYKGIGFSGSYQDVTNMDEDSGSCSQESYSFSGNLSPLDEELSVHFRGPLKLLQFGVYYPSGSNSKRQVEDCNTQHIHHKHKRATEIVQVTQTVLIDGNGNTVTSQTTETSTADDNQGGSSSPADGSSGTTSITNLAGQGKAYRSISTSSAPTTTSSDSSSSETASADGAWQRDSYYTPGNADNCVFLNYYGGSGSGVWSSKFGNSLSYANSDNSGGSSSAVALEEVTIGSNTEFVVMSGEKCSGNSCGYYREGTVAHHGFGGSNKIFIFEFEMPSDGSSGFNADMPAVWLLNAKIPRTLQYGDSSCSCWKTGCGELDLFEILSSGSNKLISHLHDGQGASSNTNNGGGGSQDYFARPTSGSLKAAVIFTSNEIHIVQVDDSTNFGSSLDEDTVNSWLQQSGSAATIGY
Protein: Zinc finger protein castor homolog 1 (Castor-related protein) (Q9CWL2)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDLGTAESTRCTDPPAGKPPMAAKRKGGLKLNAICAKLSRQVVVEKGAEAGSQAEGSPLHPRDKERSGPESGVSRAPRSEEDKRRAVIEKWVNGEYCEDPAPTPVLGRIARDQELPPEGVYMVQPQGCSDEEDHAEEPSKDNSVLEEKESDGTASKDDSGPSTRQASGETSSLRDYAASTMTEFLGMFGYDDQNTRDELAKKISFEKPHAGSTPEVAASSMLPSSEDTLSKRARFSKYEEYIRKLKAGEQLPWPAHGSKAEDRAGKEVVGPLPSLRLPSNTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIHKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPTKIPPAPSLVPTPLTNVPSAPSTPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCMYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPASLLGAKDTEHEESSNDDLVDFSALSSKNSSLSASPTSQQSSASLAAAAAATTAEAIPSATKPPNSKMAGLLPQGLSGSIPLALALSNSGLPTTTPYFPLLPNRGSASLPVGSPGLLGSMSSGATTSATPDMPALMASRAGDSAPTAATSLSVPPASIIERISASKGLISPMMARLAAAALKPSATFDPGSGQQPTPTKFPQAQVKQEPDSAGTPGPHEASQDRSLDLTVKDPSNESNGHAVSANSSLLSSLMNKMSQGNPSLESFLSIKTEAEGSPAGEPSPFLGKAVKALVQEKLSEPWKVYLRRFGTKDFCDAQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGTAKGTPEASFPTSAAETKPPLAPSSLPAPPGTMVAGSSLEGPAPSPVSVPSTPTLLAWKQLASTIPQMPQIPSSVPHLPTSPLATTSLESAKPQVKPGFLQFQDNDPCLATDCKYASKFHFHCLFGNCKYVCKTSGKAESHCLDHINPSNSLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPSLMDAETDEGMDYTGCSPGAASSESSTMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDTACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFSSSADCAVPDCKYKLKCSHFHCTYPGCRHTVVGMSQMDSHKRKHEKQERGEPPAASPGAPVNLDGSLTLAAEQGSLLFLQTAAAGLGLLGDTGDPGPPVTASGTRDGPAAPTPAAAATTTTTTTATATATAGESSQEDDEELELPEEEAEDDDEDDDEEDDDDEDDDDDDDDEDLRTDSEESLPEAAGEAGARTPLAALGGPGPAPTAAS
Protein: Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III (Beta-ketoacyl-ACP synthase III) (KAS III) (EC 2.3.1.301) (3-oxoacyl-[acyl-carrier-protein] synthase 3) (3-oxoacyl-[acyl-carrier-protein] synthase III) (MtFabH) (P9WNG3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Possesses a clear preference for long-chain acyl-CoA substrates rather than acyl-ACP primers. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall. In vitro, when AcpM (the natural partner) is used as the carrier, malonate incorporation increases with acyl chain length to reach an apparent maximum with primers ranging in length from C:14-CoA to C:20-CoA. However, the initial acylation step shows preference for dodecanoyl-CoA, suggesting a role for AcpM in determining the specificity of the mtFabH reaction. Shows only very weak activity with acetyl-CoA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01815}.
Interaction partners:
- Probable fatty acid synthase Fas
- Malonyl CoA-acyl carrier protein transacylase
- Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Enoyl-[acyl-carrier-protein] reductase
- 3-oxoacyl-[acyl-carrier-protein] reductase MabA
- Meromycolate extension acyl carrier protein
- 1,4-dihydroxy-2-naphthoate octaprenyltransferase
- Polyketide synthase Pks13
Sequence:
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
Protein: Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) (Q9D819)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
- Potassium-transporting ATPase alpha chain 2
- Potassium-transporting ATPase alpha chain 1
- Potassium-transporting ATPase subunit beta
- Inorganic pyrophosphatase 2, mitochondrial
- ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
Sequence:
MSGFSSEERAAPFTLEYRVFLKNEKGQYISPFHDVPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHSDKHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINVDDPDAANYKDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKDFAVDIIKSTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACSLPTDVDKWFHQQKN
Protein: Dachshund b (F1R4Z6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTMAVPATLPVHSGTSAVSGKLFRTEPFFSSPAEAPRIINSLPSGGTTNECKIVEVHGVKVASFSVDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDINPVVCTVEQVRVLRGLGAIQPGVNRCKLISRKDFEALYNDCTNASSRPGRPPKRSYGASVQESPRILHHRANLLSPALLSPTGLTTAAMAEALKIQKMKMMMNLHKTHNGSEFDSDELNSNAGTVCSTLSWEREKHSSPASEKTQHSLNNSQLNSLQHTHLLANRLELPFMMMPHPLLPVGLPPASVAMAMNQMNHLNTIANMVASAQVHSPVSRPTSAIKQERFEESPSLTPSVEGIVSQKTEPSPQQSSSVPSSPTHPYTHSPLKTAYDAHDEQRETDSALHVNRLSNDRVEQNAVKPALFEKVPAQTFPSGFPASLLFTDGLSSVETLLTNVQGLLKVALENARLQEKQLQQERRELKMELYREREMRESLERQLTSELRTRATIQRRLKKEKKAKRRLQEALEYESKRRGQIEQALQQATSSDSLTHDPISLEMETERCRSPEDNCLLQESRTYTKNPIIY
Protein: Lysozyme-like protein 7 (O16202)
Organism: Caenorhabditis elegans
Function: Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection.
Interaction partners:
- Saposin B-type domain-containing protein
- Pathogenesis-related protein 5-like
- VWFA domain-containing protein
- C-type lectin domain-containing protein 87
- Antibacterial factor-related peptide 2
- Saposin B-type domain-containing protein
- CUB-like domain-containing protein
- Forkhead box protein O
- Mitogen-activated protein kinase pmk-1
- C-type lectin domain-containing protein
Sequence:
MAHKSIVIFSVLAVLCHSASVKVPPIVDSSLPVKFSEVIAEPAPNVPSNLASYAYALDIYVQTTLSQLQCIKQAGYCAVFVRAYNPAGQGSFDTSSCVTIQNAYKAGLGIEIYMTPQPVSNKQGYQQLDEIIQGLTARAITVRAIWIQVTSPTNWPNNANSNINFINSIVSRARQSGLTVGIYTSYYDWNQITTGWSNIGNDVLLWYWNVYSGGVTGETPANFNDFRKFGCWTAPSVKQFAQDETVCGITVNRDVYLAGNVLKAVEEDGKIYAGGFVQGSLKI
Protein: Monocarboxylate transporter 1 (Solute carrier family 16 member 1) (Q5T8R3)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}.
Interaction partners:
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSE
Protein: Protein DCL, chloroplastic (Defective chloroplasts and leaves protein) (Q42463)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Has a function in the early stage of chloroplast development and palisade cell morphogenesis. Required for correct plastid ribosome assembly. Required for processing and maturation of 4.5S rRNA.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:8861949}.
Interaction partners:
- Uncharacterized protein
- Protein SUPPRESSOR OF GENE SILENCING 3
- AGO7
- AGO5
- AGO6
- RNA-dependent RNA polymerase
- RNA-dependent RNA polymerase
- RNA-dependent RNA polymerase
- RNA-dependent RNA polymerase
- RNA-dependent RNA polymerase
Sequence:
MASICTSNFHFLCRKNNSSPISHHLLLSPSSLSFSRCGGLRLCRCAAVKTGSEGGGIRSDNAELLRKPVISTELETTSESEELVKEESDDEVGKKSGDGEGWVDWEDQILEDTVPLVGFVRMILHSGKYAIGDRLSPDHQRTILQRLLPYHPECDKKIGPGVDYITVGYHPDFENSRCLFIVRKDGETVDFSYWKCIKGLIRKNYPLYADSFILRHFRKRRRND
Protein: ATP-binding cassette protein (Q9JL44)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
GRTGSGKSSFSLAFFRILDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTSRHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSSSPPSSARTNDSASAXVPPRTSLACLVFRTVNHL
Protein: Protein FUN14 (P18411)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Autophagy-related protein 8
- Altered inheritance of mitochondria protein 19
- Uncharacterized protein YBR053C
- Serine/threonine-protein kinase ATG1
- ULP1-interacting protein 4
- Mitochondrial outer membrane protein OM45
Sequence:
MTLAFNMQRLVFRNLNVGKRMFKNVPLWRFNVANKLGKPLTRSVGLGGAGIVAGGFYLMNRQPSKLIFNDSLGAAVKQQGPLEPTVGNSTAITEERRNKISSHKQMFLGSLFGVVLGVTVAKISILFMYVGITSMLLCEWLRYKGWIRINLKNIKSVIVLKDVDLKKLLIDGLLGTEYMGFKVFFTLSFVLASLNANK
Protein: D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) (P30729)
Organism: Rattus norvegicus (Rat)
Function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (By similarity). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10832611}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21917}.
Interaction partners:
- D
- Guanine nucleotide-binding protein G
- Catechol O-methyltransferase
- Guanine nucleotide-binding protein G
- Sodium-dependent serotonin transporter
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- Sodium-dependent dopamine transporter
- Guanine nucleotide-binding protein G
Sequence:
MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC