wanglab/gogpt-training-data huggingface dataset:
Protein: Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344) (F6Q1T7)
Organism: Bos taurus (Bovine)
Function: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent, fucosylates glycolipids gangliosides GA1 and GM1a.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:O09160}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O09160}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250|UniProtKB:O09160}.
Interaction partners:
Sequence:
MWAPGHHHLCLIFLLTCVFACVFFLLIHQNLFHSGLDLFLPCPDRSRVRSPVAILCLSGTLMNPNATFTCPRHSASVSGTWTIDPKGRFGNQMGQYATLLALAQLNGRQAFIQPSMHAVLAPVFRITLPVLAPEVDRHAPWQELELHDWMSEEYAHLKEPWLKLTGFPCSWTFFHHLRDQIRSEFTLHEHLRQEAQRSLSGLRFPRTGGRPSTFVGVHVRRGDYLQVMPLHWKGVVGDRAYLQQAMDWFRARHKAPIFVVTSNGMKWCRENIDTSRGDVIFAGDGQEGAPNKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTIYLANFTLPDSSFLKIFKPEAAFLPEWVGINADLSPLQ
Protein: UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase (UDP-3-oxo-D-GlcNAcA aminotransferase) (EC 2.6.1.98) (UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronic acid transaminase) (UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase) (Q9HZ76)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the amination of UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA) to UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid (UDP-GlcNAc3NA), using L-glutamate as the preferred amine donor.
Interaction partners:
- UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase
- UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
- UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase
- UDP-N-acetyl-D-glucosamine 6-dehydrogenase
- Probable glycosyl transferase WbpJ
- O-antigen translocase
- LPS biosynthesis protein WbpG
- Probable glycosyltransferase WbpH
- Putative imidazole glycerol phosphate synthase subunit hisF2
- Imidazole glycerol phosphate synthase subunit HisH 2
Sequence:
MIEFIDLKNQQARIKDKIDAGIQRVLRHGQYILGPEVTELEDRLADFVGAKYCISCANGTDALQIVQMALGVGPGDEVITPGFTYVATAETVALLGAKPVYVDIDPRTYNLDPQLLEAAITPRTKAIIPVSLYGQCADFDAINAIASKYGIPVIEDAAQSFGASYKGKRSCNLSTVACTSFFPSKPLGCYGDGGAIFTNDDELATAIRQIARHGQDRRYHHIRVGVNSRLDTLQAAILLPKLEIFEEEIALRQKVAAEYDLSLKQVGIGTPFIEVNNISVYAQYTVRMDNRESVQASLKAAGVPTAVHYPIPLNKQPAVADEKAKLPVGDKAATQVMSLPMHPYLDTASIKIICAALTN
Protein: Chorion protein S18 (P07184)
Organism: Drosophila melanogaster (Fruit fly)
Function: Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
Subcellular location: Secreted.
Interaction partners:
- Chorion protein S16
- Chorion protein S15
- Chorion protein S19
- Chorion protein S36
- Chorion protein S38
- Femcoat
- Uncharacterized protein
- Mucin 12Ea
- Vitelline membrane protein Vm34Ca
- Vitelline membrane protein Vm26Aa
Sequence:
MMKFMCICLCAISAVSANSYGRSRGGYGGAPVGGYAYQVQPALTVKAIVPSYGGGYGGNHGGYGGAYESVPVPVSSAYSGANVGSQYSGSGYGGAPPVDAQAIALAKLALAAPSAGAPLVWKEAPRYAQPVYPPTSYVNQEYGHSEKVKGGSAAAAASSVAAGKKGYKRPSY
Protein: Cellulose synthase A catalytic subunit 5 [UDP-forming] (AtCesA5) (EC 2.4.1.12) (Q8L778)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Fasciclin-like arabinogalactan protein 4
- Cellulose synthase A catalytic subunit 3
- LRR receptor-like serine/threonine-protein kinase FEI 2
- Cellulose synthase A catalytic subunit 1
- Protein CELLULOSE SYNTHASE INTERACTIVE 1
- LRR receptor-like serine/threonine-protein kinase FEI 1
- Peroxidase 36
- Beta-galactosidase 6
- COBRA-like protein 2
- Transmembrane E3 ubiquitin-protein ligase FLY1
Sequence:
MNTGGRLIAGSHNRNEFVLINADESARIRSVEELSGQTCQICGDEIELSVDGESFVACNECAFPVCRPCYEYERREGNQSCPQCKTRYKRIKGSPRVEGDEEDDGIDDLDFEFDYSRSGLESETFSRRNSEFDLASAPPGSQIPLLTYGEEDVEISSDSHALIVSPSPGHIHRVHQPHFPDPAAHPRPMVPQKDLAVYGYGSVAWKDRMEEWKRKQNEKYQVVKHDGDSSLGDGDDADIPMMDEGRQPLSRKVPIKSSKINPYRMLIVLRLVILGLFFHYRILHPVNDAYALWLISVICEIWFAVSWVLDQFPKWYPIERETYLDRLSLRYEKEGKPSELAGVDVFVSTVDPMKEPPLITANTVLSILAVDYPVDRVACYVSDDGAAMLTFEALSETAEFARKWVPFCKKYTIEPRAPEWYFCHKMDYLKNKVHPAFVRERRAMKRDYEEFKVKINALVATAQKVPEEGWTMQDGTPWPGNNVRDHPGMIQVFLGNNGVRDVENNELPRLVYVSREKRPGFDHHKKAGAMNSLIRVSGVLSNAPYLLNVDCDHYINNSKALREAMCFMMDPQSGKKICYVQFPQRFDGIDKSDRYSNRNVVFFDINMKGLDGLQGPIYVGTGCVFRRQALYGFDAPKKKKTKRMTCNCWPKWCLFCCGLRKNRKSKTTDKKKKNREASKQIHALENIEEGTKGTNDAAKSPEAAQLKLEKKFGQSPVFVASAGMENGGLARNASPASLLREAIQVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHSHGWRSVYCTPKIPAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPIWYGYGGGLKWLERLSYINSVVYPWTSIPLLVYCSLPAICLLTGKFIVPEISNYASILFMALFGSIAVTGILEMQWGKVGIDDWWRNEQFWVIGGVSAHLFALFQGLLKVLAGVETNFTVTSKAADDGEFSELYIFKWTSLLIPPTTLLIINVIGVIVGISDAISNGYDSWGPLFGRLFFAFWVILHLYPFLKGLLGKQDRMPTIILVWSILLASILTLLWVRVNPFVAKGGPILEICGLDCL
Protein: Mannosyl-oligosaccharide alpha-1,2-mannosidase IA (EC 3.2.1.113) (Alpha-1,2-mannosidase) (Class I alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) (SfManI) (O18498)
Organism: Spodoptera frugiperda (Fall armyworm)
Function: Involved in the maturation of Asn-linked oligosaccharides. Converts Man(9)GlcNAc(2) to Man(5)GlcNAc(2) primarily through the Man(7)GlcNAc(2) isomer C processing intermediate.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:11222938}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8H116}. Note=Localizes in cytoplasmic punctate structures representing Golgi elements. {ECO:0000269|PubMed:11222938}.
Interaction partners:
Sequence:
MTGILPTYQRFVNGVPVPSISRRSFRLREKYLIVSVLLTFGIVWLGALFYLPEFKSSNSVNDSVYNVYKRIQKAGPELLMPPPLAQNDVGDFPVIGIAHHGEGGDDPHVIEDRNRLRAKIEEDMGMKVLERPQFDVAPSVSSSRGPSKPPVDAIEEPAVGNNAANKDVSPSGPKAESSDKFVAVALAPGADPEIKHKLETVKKMMLHAWYNYKLYAWGKNELKPMSKRAHLSSVFGAGELGATIVDGLDTLYLMGLNDEFREGRDWVAEHLHINEIDSDLSVFETTIRFVGGLLSCYALTGDTMFRDKAAEVGDALLPAFDTPTGLPYALINPSTKASRQYHWAGPNSILSELGTLHLEFTYLSDVTGRDIYRQKVSRIREVLDQIDKPGDLYPNFINPRTGQWGQRHMSLGALGDSFYEYLLKAWLMSGGADEQARIMFDTAMQAALDKMLRVSPSGLAYLAELKYGRIIEEKMDHLSCFAGGMFALASTTLDNSMSERYMDVAKKLTNTCHESYARSETKLGPEAFRFSNAAEARAQKSNEKVYLLRPETFESYFIMWRLTKQQMYRDWAWEAVQALEKHCRVEGGYTGLVNVYHANPQGDDVQQSFFLAETLKYLYLIFGDDSFLPLDEWVFNTEAHPFPIRGKNPLYRAVDKPVLPEPAHAQNNRI
Protein: Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1) (P03564)
Organism: Tomato golden mosaic virus (strain Yellow vein) (TGMV)
Function: Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus. Begomoviruses use 2 proteins to transport their DNA from cell to cell. The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall (By similarity).
Subcellular location: Host nucleus {ECO:0000250}. Host cytoplasm {ECO:0000250}. Host cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocated to the plasma membrane by the movement protein BC1. {ECO:0000250}.
Interaction partners:
Sequence:
MYSTKYRRGFLANQGRGYPRHSTGKRSRNVSRIDFKRRSSKYVHGNDDSKMANQRIHENQFGPEFVMVHNTAISTFITFPSLGKTEPSRSRSYIKLKRLRFKGTVKIERVHVDLSMDGPSPKIEGVFSLVVVVDRQPHLSPTGCLHTFDELFGARIHSHGNLAVSSALKDRFYIRHVFKRVISVEKDSTMIDLEGMTSFTNRRFNCWSAFKDFDRQACNGVYGNISKNAILVYYCWMSDIVSKASTFVSFDLDYVG
Protein: Large ribosomal subunit protein mL42 (S4R360)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGR
Protein: Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Fructose-1,6-bisphosphatase isozyme 3) (FBPase 3) (Liver FBPase) (Q9QXD6)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Interaction partners:
- Fructose-bisphosphate aldolase B
- Glucose-6-phosphate isomerase
- Transaldolase
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
- Transketolase
- Hexokinase-2
- ATP-dependent 6-phosphofructokinase, liver type
- Transketolase-like protein 1
- ATP-dependent 6-phosphofructokinase, platelet type
- Transketolase-like protein 2
Sequence:
MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK
Protein: Thiazole synthase (EC 2.8.1.10) (P30139)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Subcellular location: Cytoplasm.
Interaction partners:
- Sulfur carrier protein ThiS adenylyltransferase
- Sulfur carrier protein ThiS
- Thiamine-phosphate synthase
- 2-iminoacetate synthase
- Phosphomethylpyrimidine synthase
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
- tRNA sulfurtransferase
- 1-deoxy-D-xylulose-5-phosphate synthase
- Hydroxyethylthiazole kinase
- Thiamine-monophosphate kinase
Sequence:
MLRIADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILEPLIAAGVTLLPNTSGAKTAEEAIFAAHLAREALGTNWLKLEIHPDARWLLPDPIETLKAAETLVQQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETRAMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVNMAKAFRLAVEAGLLARQSGPGSRSYFAHATSPLTGFLEASA
Protein: Basic endochitinase B (EC 3.2.1.14) (Pathogenesis-related protein 3) (AtChiB) (PR-3) (P19171)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Defense against chitin-containing fungal pathogens. Seems particularly implicated in resistance to jasmonate-inducing pathogens such as A.brassicicola. In vitro antifungal activity against T.reesei, but not against A.solani, F.oxysporum, S.sclerotiorum, G.graminis and P.megasperma.
Subcellular location: Vacuole {ECO:0000269|PubMed:23738689}.
Interaction partners:
- Osmotin-like protein OSM34
- CAP superfamily protein
- Pathogenesis-related protein 1
- Pathogenesis-related protein 1
- Pathogenesis-related protein 5
- Defensin-like protein 16
- Glucan endo-1,3-beta-glucosidase, acidic isoform
- Regulatory protein NPR1
- Pathogenesis-related protein 1
- Class V chitinase
Sequence:
MPPQKENHRTLNKMKTNLFLFLIFSLLLSLSSAEQCGRQAGGALCPNGLCCSEFGWCGNTEPYCKQPGCQSQCTPGGTPPGPTGDLSGIISSSQFDDMLKHRNDAACPARGFYTYNAFITAAKSFPGFGTTGDTATRKKEVAAFFGQTSHETTGGWATAPDGPYSWGYCFKQEQNPASDYCEPSATWPCASGKRYYGRGPMQLSWNYNYGLCGRAIGVDLLNNPDLVANDAVIAFKAAIWFWMTAQPPKPSCHAVIAGQWQPSDADRAAGRLPGYGVITNIINGGLECGRGQDGRVADRIGFYQRYCNIFGVNPGGNLDCYNQRSFVNGLLEAAI
Protein: 2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein) (A1L0T0)
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28289220}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Alanine--glyoxylate aminotransferase
- Citrate synthase, mitochondrial
- Myocardin-related transcription factor A
- Guanosine-3',5'-bis
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- 2-iminobutanoate/2-iminopropanoate deaminase
- Cytochrome c oxidase subunit 3
- Branched-chain-amino-acid aminotransferase, mitochondrial
- 2-Hydroxyacid oxidase 2
Sequence:
METPAAAAPAGSLFPSFLLLACGTLVAALLGAAHRLGLFYQLLHKVDKASVRHGGENVAAVLRAHGVRFIFTLVGGHISPLLVACEKLGIRVVDTRHEVTAVFAADAMARLSGTVGVAAVTAGPGLTNTVTAVKNAQMAQSPILLLGGAASTLLQNRGALQAVDQLSLFRPLCKFCVSVRRVRDIVPTLRAAMAAAQSGTPGPVFVELPVDVLYPYFMVQKEMVPAKPPKGLVGRVVSWYLENYLANLFAGAWEPQPEGPLPLDIPQASPQQVQRCVEILSRAKRPLMVLGSQALLTPTSADKLRAAVETLGVPCFLGGMARGLLGRNHPLHIRENRSAALKKADVIVLAGTVCDFRLSYGRVLSHSSKIIIVNRNREEMLLNSDIFWKPQEAVQGDVGSFVLKLVEGLQGQTWAPDWVEELREADRQKEQTFREKAAMPVAQHLNPVQVLQLVEETLPDNSILVVDGGDFVGTAAHLVQPRGPLRWLDPGAFGTLGVGAGFALGAKLCRPDAEVWCLFGDGAFGYSLIEFDTFVRHKIPVMALVGNDAGWTQISREQVPSLGSNVACGLAYTDYHKAAMGLGARGLLLSRENEDQVVKVLHDAQQQCRDGHPVVVNILIGRTDFRDGSIAV
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q8ILM8)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- UBX domain-containing protein, putative
- Cell division cycle protein 48 homologue, putative
- Putative cell division cycle ATPase
- AAA family ATPase, putative
- Zinc finger protein, putative
- Ubiquitin-protein ligase, putative
- Ubiquitin-protein ligase, putative
- Sel1 repeat-containing protein, putative
- Nuclear protein localization protein 4, putative
Sequence:
MELNMRLYILLSHLGLAFILMYAFMKYDEFYLAVVYLSTEKFPRTIIYNFFLMVFIVLCKLLLNVFIGELRYLEVEQLIDNARAFIMDTILFLVLSKPTINGKEVSSIILIKYLSIIVILKAYHLVLYSRVSNIFELGVPRTRVLVKLFIFMCLLSIANLSLFTYFYKNSLKNSTMYLWLFFECLSIFESCQISICKFFVNVIDLRSQNGLSSKATILFFLDILHDIMSLIIFLVFILVFVLNNFSNLPLHMTADIIHVVKTLISRFKSFQKYRELTKNIETKFANATEEELKEAGTCIICRDDLKEGSKKLSCSHIFHVDCLKSWFIQQQTCPICRTEIKPYAKNEQNKSENDTTQKEKQEEKIEQPTIQEIITKPNFLINDQHLYLNDTNVMGTLNINQQYYPPINKNINTKEQIKILMDLCNYYRELSLVCLKEIDKINHSSIPANVMLRNIYGSIHYNILNNMEDDEVQKYLNKISHIPQMKGLKEYIEKVLITDMKYTKDICSSL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0A6YYC0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
TEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAP
Protein: Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2) (Q8N2K1)
Organism: Homo sapiens (Human)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y385}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9Y385}.
Interaction partners:
- E3 ubiquitin-protein ligase TM129
- E3 ubiquitin-protein ligase MARCHF6
- Derlin-1
- Adaptin ear-binding coat-associated protein 1
- Adaptin ear-binding coat-associated protein 2
- Transitional endoplasmic reticulum ATPase
- Ubiquitin-conjugating enzyme E2 G2
- Selenoprotein S
- Ubiquitin-like modifier-activating enzyme 1
- Beta-1,3-galactosyltransferase 6
Sequence:
MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE
Protein: Transmembrane protein 234 (B8A4M3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFRPGEVFCLLLVAILWGGTNPFLKKGTEGIEEVQKKNKLLQFLAELKFLFLNFKYLVPFLLNQSGSLVFYFTLASTDLSLAVPVVNSLTFLFTLLMGKVLGEEFGGKGAIMGMLLIMCGVTVCVLSSVSETHGIGARNISET
Protein: Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein-coupled receptor kinase 2) (P26817)
Organism: Rattus norvegicus (Rat)
Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1403099}. Cell membrane {ECO:0000250|UniProtKB:P21146}. Postsynapse {ECO:0000269|PubMed:1403099}. Presynapse {ECO:0000269|PubMed:1403099}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
- Beta-arrestin-1
- Protein smoothened
- ARF GTPase-activating protein GIT1
- Mu-type opioid receptor
- Beta-2 adrenergic receptor
- non-specific serine/threonine protein kinase
- C-X-C chemokine receptor type 2
- Casein kinase I isoform gamma-2
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFYLNHLEEAKPLVEFYEEIEKYEKLETEEERVVRSREIFDSYIMKELLACSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFHKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEIKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEDEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL
Protein: Vacuole membrane protein 1 (K7ELS2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQRLNSEEKTK
Protein: Cbp/p300-interacting transactivator 2 (Q99MA1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone lysine acetyltransferase CREBBP
- Forkhead box O3
- Hypoxia-inducible factor 1-alpha
- LIM/homeobox protein Lhx2
- TAL bHLH transcription factor 2
Sequence:
MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGAGGSGTPGGSGGTSGGAGGSSAGGSGGGSTMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC
Protein: Spermidine/putrescine import ATP-binding protein PotA (EC 7.6.2.11) (P69874)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01726, ECO:0000269|PubMed:1939142, ECO:0000269|PubMed:7592703}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01726, ECO:0000269|PubMed:1939142, ECO:0000269|PubMed:7592703}.
Interaction partners:
- Spermidine/putrescine transport system permease protein PotC
- Spermidine/putrescine transport system permease protein PotB
- Spermidine/putrescine-binding periplasmic protein
- Putrescine transport system permease protein PotH
- Putrescine transport system permease protein PotI
- Putrescine-binding periplasmic protein PotF
- Nickel import ATP-binding protein NikD
- sn-glycerol-3-phosphate transport system permease protein UgpA
- sn-glycerol-3-phosphate transport system permease protein UgpE
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydC
Sequence:
MGQSKKLNKQPSSLSPLVQLAGIRKCFDGKEVIPQLDLTINNGEFLTLLGPSGCGKTTVLRLIAGLETVDSGRIMLDNEDITHVPAENRYVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLETFAQRKPHQLSGGQQQRVAIARAVVNKPRLLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVAGFIGEINMFNATVIERLDEQRVRANVEGRECNIYVNFAVEPGQKLHVLLRPEDLRVEEINDDNHAEGLIGYVRERNYKGMTLESVVELENGKMVMVSEFFNEDDPDFDHSLDQKMAINWVESWEVVLADEEHK
Protein: Precursor of elicitor peptide 1 [Cleaved into: Elicitor peptide 1 (AtPep1)] (Q9LV87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Elicitor of plant defense. Induces the production of plant defensin (PDF1.2) and of H(2)O(2). Promotes resistance to the root fungal pathogen P.irregulare. Triggers the expression of several PROSCOOP genes (e.g. PROSCOOP2, PROSCOOP7, PROSCOOP8, PROSCOOP12 and PROSCOOP13).
Interaction partners:
- Leucine-rich repeat receptor-like protein kinase PEPR1
- Leucine-rich repeat receptor-like protein kinase PEPR2
- Elicitor peptide 3
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Phytosulfokine receptor 1
- Protein BRASSINOSTEROID INSENSITIVE 1
- Wall-associated receptor kinase 1
- Serine/threonine-protein kinase BIK1
- LRR receptor-like serine/threonine-protein kinase EFR
- Elicitor peptide 7
Sequence:
MEKSDRRSEESHLWIPLQCLDQTLRAILKCLGLFHQDSPTTSSPGTSKQPKEEKEDVTMEKEEVVVTSRATKVKAKQRGKEKVSSGRPGQHN
Protein: G protein-coupled receptor 177 (Q7T357)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}.
Interaction partners:
Sequence:
MAGAIIENMSTKKLVILGVILMLFQAFSFMVGGLIAPSPTAAVSYLATKCVDNEKTHHKNPKWFTPWGPDQCSKIKDFDEAMVKKIEANNIVFAIHIPPPNTEMSTWFQFLLLILHFDIAFKIQNQIADGASITIDVRLAYRDDKLSEWTQMAHSVEQRKLSCNFTAAKTIENEGRLYDCDLLPFMELGSVAHKYYLLNVRLPVNERKKVNIGIGEINDMRLVGIHQNGGFTKVWFAMKTFLTPSVLIIMIWYWKRITQMTRPPVLLEKVIFALGISMTFINIPVEWFSVGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHLMDQTERNRFSVYWKQVIPIVFGSFCLFIFDMCERGVQLKNPFYSIWASDVGTELAMAFIIVAGICACLYFLFLCFMVFQVFRNISGKRSCLPAMTKARRLHYEGLIFRFKFLMLVTLACAAMTVIFFIISQVSEGHWLWGGHTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKRYGDEQSSADQVGNSGEDTQLTTTITHVDGPTEIYKMTGKEAQE