Protein: NAD(+) hydrolase tir-1 (NADase tir-1) (EC 3.2.2.6) (Neuronal symmetry protein 2) (SARM1 homolog) (Sterile alpha and TIR motif-containing protein tir-1) (Q86DA5)
Organism: Caenorhabditis elegans
Function: NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant receptor expression. Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp-31. Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway. Involved in the response to anoxic conditions probably by activating the p38 pathway composed of nsy-1/sek-1/pmk-1. Involved in regulation of the serotonergic response of ADF neurons to pathogenic food. In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15625192}.
Interaction partners:
- Mitogen-activated protein kinase pmk-1
- Mitogen-activated protein kinase kinase kinase nsy-1
- Dual specificity mitogen-activated protein kinase kinase sek-1
- Calcium/calmodulin-dependent protein kinase type II
- TIR domain-containing protein
- Mitogen-activated protein kinase pmk-2
- Transcription factor atf-7
- Clc-like protein
- Cullin-1
- Mitogen-activated protein kinase pmk-3
Sequence:
MLPNRKPPRPSPSFQSLNNNNQRFPLRRSLKIAQAHSLPTVPSEDAKDDDLITPELSTDFDFREIQHRYLMALQNEQDGETTSTDDAFFELDDDDDLSSPSVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIHEARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFTPTGSQERATSTRRKIQPSASTTSDRN