wanglab/gogpt-training-data huggingface dataset:
Protein: Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) (P12063)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Has both an aminoacyl-tRNA synthetase activity and is involved in the splicing of group I introns. It acts in intron splicing by stabilizing the catalytically active structure of the intron.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Tyrosine--tRNA ligase
- Leucine--tRNA ligase, mitochondrial
- Leucine--tRNA ligase, cytoplasmic
- ATP-dependent RNA helicase cyt-19, mitochondrial
- glutamine--tRNA ligase
- arginine--tRNA ligase
- Valine--tRNA ligase, mitochondrial
- Tryptophan synthase
- NADH-ubiquinone oxidoreductase chain 1
- glycine--tRNA ligase
Sequence:
MLLRTKALIRSGGSIAKYAAANPSCFILQRRGLRREFGPKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIAELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGSTAKIGDPTGRLKSRDHLSSSDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNNNHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPIMQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKYVTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYFVRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTLVHGKQEASAAEDQHRMMYTGQMTIPQVSRAKDAATGGDQYKTISDQPVTLNNAPRIDMILPESLIMGKSIGRILYAAGLASSTTEGHKLAAAQGCYVGGAHRAGGENVTMNPDLISFMPVKLWFPGETQRYLINGNLLILRKGKHNVRVIQMVSDVEYAASGQTYPGQSFTGAVRKLNEIMKNLKEKKLTPEEAKNAVNELQKSSQEKQQGQQIIFPEEKSRQKKDMETKLKQEMIASVKTIDGMMDEKPSVRGDGVKKQTQDDRDPYKW
Protein: Spermidine hydroxycinnamoyltransferase 1 (EC 2.3.1.-) (Q2QRK9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydroxycinnamoyl transferase that catalyzes the transfer of an acyl from p-coumaryol-CoA to spermidine, to produce coumaroyl spermidine. Can use feruloyl-CoA as acyl donor. Contributes to the natural variation of spermidine-based phenolamides in rice cultivars.
Interaction partners:
Sequence:
MKLDSFMVTRRGNPELVAPARATPRGTKPLSDLDDDWDLRYLQPCLEFFRAVDDGERRKPARPGDAIRAALAEALVYYYPIAGRLRELPKGGRLAVECTGEGVVFVEAEADVRIEDLGEPPLPTFRGAESFLCDVGDAGVVVGRPLFYMQITHLKCGGFVLGTHICHCIADAFGTLQFLKAIVDIARGEAKPTTLPVWEREHFVATSLPPNIKEEQEKLFDELENTTCDDIMVTMPAENMVSEYFTISQRDMIALRRHVPFNLTKTVTSFELLTAVLWRSRTMALGYKPCQIVRLMITVNARGRWKKLPLGYYGNGLLCPVIEITVNDLCTNSLGHTIELVRKAKHEMKTKENMQLMVDLLPLWREKPYIKVERIFETCDIKWIGQDTLDIGWAKRIGGGIPTVSLPDMTSYQFMCKNEKGDHILVFHTTNAVMHLPLVIKRK
Protein: CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase) (Q4GZ95)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase, putative
- Nucleoside diphosphate kinase, putative
- GMP synthase
- Large ribosomal subunit protein uL5
- 60S ribosomal protein L13a, putative
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L2, putative
- 60S ribosomal protein L4
Sequence:
MEGSATAKAYMLPSPELRPVSGTGACKYIVVTGGVCSSLGKGVTTSATGALLRAEGYQVCSIKIDPYINMDAGLMSPYEHGEVYVLDDGGEVDLDLGNYERWMSVQLRREHNITTGKVYQKLINKERQGGFLGKTVQLVPHFTNDVVESIFRVSQSPVDESGAQPEICMIELGGTVGDMESQPFVEALRRLRCLVGPDEFCLMHTTYLPVFGGSQKTKPTQHSTRTLLSMGLQPDILICRSENRLTPDAKEKLSNLCGVRSGDIVSAPNVSCLYEVPVVFTKDGLVDRLVEKLRLVKRTPATDVPRIDTYKTYVKILRNMSNPTVRIAFVGKYLQDAGDTYFSVLQCFEHCQIALQVRLDILYVDSEELEGPNADEARKALLGCDGIFVPGGFGNRGVDGKCAAAQVARMNNIPYFGVCLGMQVAVIELSRNVVGWSDANSEEFNKESTHQVVRIMDCDRNKMGANMHLGACDVHIVEKSSIMAKIYSKSNIVVERHRHRYEVNTAYFEDLRKAGLCISAVTDPTFSSRCRVEAVENPSLRFFLAVQFHPEFISTPMDPAPTYLSFMAAAAKKDYVWPQKCSQRRLKQA
Protein: POU domain protein 2, isoform B (Miti-mere) (Pdm-2) (Protein didymous) (dOct2) (dPOU-28) (Q9VK71)
Organism: Drosophila melanogaster (Fruit fly)
Function: DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
Subcellular location: Nucleus {ECO:0000255}.
Interaction partners:
- Protein nubbin
- Protein hunchback
- SOX domain-containing protein dichaete
- Transcription factor btd
Sequence:
MPLLLATTLANNSHHQHLSTTATETAAAAATAKAAATAAAAATATMLLTSPTAATHCLAAATSAAGVNVQITGQGVSATLNDDQLQLPANYAANVGHLNGFNPKDNCPPVPPTSERAFEGLLRLPQIQVKQEFMESPPERPSCHPMNHQQAPANSALATSCRGKTILNPWYLRPADGIGYHNYNSNNNNSGSGEINKDVSQQMTSACGGSDGQTCLPVSYFGMETLASVKQRQKSLPDFLIPLHEIMFQQQHHYQQRTMGTLINSLPPGLVGYPPQKTETFKSLTPPKALQHHQNNQNHQIPQNHTGDHSFVRHFHERDRLIREHQLKHQQLRDVEEVLQEQEQDEEQEHETLRKPHVVPSELEHNHHWHGVVCDANGHATRLLHIAPPRAGPTPLPTHQQPPVGEVLPPNSTSFSTIVDPPKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLSSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLHSYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTPLAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDSPTGTPLSSHAFGYPPQALNMSHMQMEGGSGSFCGSSISSGE
Protein: Endoglucanase 5 (EC 3.2.1.4) (Endo-1,4-beta glucanase 5) (Q9M995)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Protein SEED AND ROOT HAIR PROTECTIVE PROTEIN
- Peroxidase 7
- At5g05500
- Pollen Ole e 1 allergen and extensin family protein
- Peroxidase 44
- COBRA-like protein 9
- Glucuronoxylan 4-O-methyltransferase 2
- Extensin-like protein
- Putative disease resistance protein At3g15700
- Uncharacterized protein
Sequence:
MRKFGGSLFGVSLLLSVLLAAATAAAEYYNYGSALDKTFLFFEAQRSGKLPAAQRVKWRGPSGLKDGLAQGVSLEGGYYDAGDHVKFGLPMAFAVTMLSWAAVDNRKELSSSNQMQQTLWSIRWGTDYFIKAHPQPNVLWGQVGDGESDHYCWERPEDMTTSRTAYKLDPYHPGSDLAGETAAALAAASLAFKPFNSSYSALLLSHAKELFSFADKYRGLYTNSIPNAKAFYMSSGYSDELLWAAAWLHRATGDQYYLKYAMDNSGYMGGTGWGVKEFSWDNKYAGVQILLSKILLEGKGGIYTSTLKQYQTKADYFACACLKKNGGYNIQTTPGGLMYVREWNNLQYASAAAYLLAVYSDYLSAANAKLNCPDGLVQPQGLLDFARSQADYILGKNRQGMSYVVGYGPKYPIRVHHRGSSIPSIFAQRSSVSCVQGFDSWYRRSQGDPNVIYGALVGGPDENDNYSDDRSNYEQSEPTLSGTAPLVGLFAKLYGGSLGSYGGGSYKPYETTKPAASSYKATPTTYSPKQSGAQIEFLHSITSNWIAGNTRYYRHKVIIKNNSQKPISDLKLKIEDLSGPIWGLNPTGQKYTYQLPQWQKTLRAGQAYDFVYVQGGPQAKVSVLSYN
Protein: Uncharacterized protein (Q38D74)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Interaction partners:
Sequence:
MRRIMSPRVMCEVKFGSRPAPLACSRMFFIPPQLAKLIVTSGLLIVKAFLVAHQQEAKRLREEEEKEGHSATNAQVGTGSAALMTSSEALQILGLQPNMSVPLTAESDRQLAAVRFEHLFAIATRCKNVFLQGKLSGAYRVCVDPEWDLKDEVKDSHGNSRGNDAMW
Protein: Down syndrome cell adhesion molecule 1, isoform BJ (A0A0B4K7T5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVNQYYEAEVVSEYVIRGNTAVLKCTIPSFVADFLRVEAWVASDGTEYAPEEDFDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVAPKVDPNDRIKWVDKPRGSSLNLLCPAQSFPMPSARWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMEPPMLSPLLLSASVCDVGDYVQLTCIASRGSTPIMFEWWLDGRQVHDDGNDDVTQATVGEHTSLLLINRAGEGHAGNYSCRAINQVGVAERRTRLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Zinc finger CCCH domain-containing protein 14 (G3V5I6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus speckle {ECO:0000256|RuleBase:RU369058}. Note=Colocalizes with poly(A) RNA in nuclear speckles. {ECO:0000256|RuleBase:RU369058}.
Interaction partners:
Sequence:
MSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADSGVHLNRLQFQQQQNSIHAAKQLDMQSSWVYETGRLCEPEVLNSLEETYSPFFRNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEKNQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTINVPPRHALKWIRPQTSE
Protein: Dihydrodipicolinate reductase-like protein CRR1, chloroplastic (4-hydroxy-tetrahydrodipicolinate reductase 3) (HTPA reductase 3) (Protein CHLORORESPIRATORY REDUCTION 1) (Q9FJ82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dihydrodipicolinate reductase (DHPR)-like protein that may not function as DHPR in lysine biosynthesis. Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. May function in assembly or stabilization of the NDH complex.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:17727612}.
Interaction partners:
- aspartate-semialdehyde dehydrogenase
- NAD
- Photosynthetic NDH subunit of lumenal location 1, chloroplastic
- Protein CHLORORESPIRATORY REDUCTION 7
- NAD
- Protein NDH-DEPENDENT CYCLIC ELECTRON FLOW 5
- Protein CHLORORESPIRATORY REDUCTION 6
- Photosynthetic NDH subunit of subcomplex B 3, chloroplastic
- NAD
- Diaminopimelate decarboxylase 1, chloroplastic
Sequence:
MAAVNCHFFQLSRHLKPSRPSFSCSASQPSQNNIKVIINGAAKEIGRAAVVAVTKARGMELAGAVDNHFVGEDIGLLCDMEEPLEIPVVSDLTMVLGSISQGKEVGVVIDFTDPSTVYENVKQATAFGMKSVVYVPRIKPETVSALSALCDKATMGCLVAPTLSIGSILLQQAVIMASFHYNNVELVESRPNAADLPSPEAIQIANNISNLGQIYNREDSSTDVQARGQVIGEDGVRVHSMVLPGLPSSTQVYFSSPGDVYTVKHDIIDVRSLMPGLLLAIRKVVRLKNLVYGLEKFL
Protein: RAN GTPase activating protein 1 (F1MAA5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- E3 SUMO-protein ligase RanBP2
- SUMO-conjugating enzyme UBC9
- Small ubiquitin-related modifier 1
- Ran-specific GTPase-activating protein
- GTP-binding nuclear protein Ran
- Small ubiquitin-related modifier
- Regulator of chromosome condensation
- Small ubiquitin-related modifier 2
- Exportin-1
- Small ubiquitin-related modifier
Sequence:
MASEDIAKLAETLAKTQVAGGQLSFKGKGLKLNTAAKDVIKEIEEFDGLEALRLEGNTVGVEAARVIAKALEKKSKLKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLTLKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVADKAELEKLDLNGNALGEEGCEQLQEVLDSFNMAKVLASLSDDEGEDEDEDEEGEDDEDEEDEEEEEEEEEEEEEEEEEPQQRGSGEEPATPSRKILDPNSGEPAPVLSSPPPTDLSTFLSFPSPEKLLRLGPKVSVLIVQQTDTSDPEKVVSAFLKVASVFRDEASVKTAVLDAIDALMKKAFSSSSFNSNTFLTRLLIHMGLLKSEDKIKAIPSLHGPLMVLNHVVQQDYFPKTLAPLLLAFVTKPNGALESCSFARHSLLQTLYSI
Protein: Glucan endo-1,3-beta-glucosidase 8 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase 8) ((1->3)-beta-glucanase 8) (Beta-1,3-endoglucanase 8) (Beta-1,3-glucanase 8) (Q6NKW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000305}. Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 36
- Beta-glucosidase 8
- Protein STRICTOSIDINE SYNTHASE-LIKE 3
- Phosphatidate phosphatase PAH2
- Actin-related protein 4
Sequence:
MSNLLALVVGFVIVIGHLGILVNGLGVNWGTMATHKLPPKTVVQMLKDNNINKVKLFDADETTMGALAGSGLEVMVAIPNDQLKVMTSYDRAKDWVRKNVTRYNFDGGVNITFVAVGNEPFLKSYNGSFINLTFPALANIQNALNEAGLGNSVKATVPLNADVYDSPASNPVPSAGRFRPDIIGQMTQIVDFLGKNNAPITINIYPFLSLYGNDDFPLNYAFFDGAEPINDNGIDYTNVFDANFDTLVSSLKAVGHGDMPIIVGEVGWPTEGDKHANAGSAYRFYNGLLPRLGTNKGTPLRPTYIEVYLFGLLDEDAKSIAPGPFERHWGIFKFDGQPKFPIDLSGQGQSKFLIGAQNVPYLPNKWCTFNPEAKDLTKLAANIDYACTFSDCTALGYGSSCNTLDANGNASYAFNMFFQVKNQDESACYFQGLATITTQNISQGQCNFPIQIVASSASSFSCSSYSLVVLIVWFLLSGMMF
Protein: Acyl-CoA oxidase C-terminal domain-containing protein (Q586U0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- propanoyl-CoA C-acyltransferase
- Nonspecific lipid-transfer protein, putative
- Electron transfer flavoprotein subunit alpha
- Electron transfer flavoprotein subunit beta
- Peroxisome targeting signal 1 receptor
- MaoC-like dehydratase, putative
- Probable enoyl-CoA hydratase, mitochondrial
- Peroxin-13
- Peroxisomal membrane protein PEX14
- RING-type E3 ubiquitin transferase
Sequence:
MMCKGLFSKLPPNIVYRFLYANTGLKSCCWKAPLTAQRRTFHRSPQLHFELNPSQQMYSMEHAFEEPTFRFICEGIDIDYKEEVRRALMEVLPRNPSNFVVRDDLPQSQGSSVQRTVQLLRAIAKKRLLSFAQVNSTPQLFCTFYEVIAMCCTPLALLAADHFTFAAMIALYGSKEMKALLLDHVDSCHIVGAIAHRELIAEGVPLNTEARYNRGENVFVLRGSGKFAVVGAVCADWAIVTATLTLNKDDNMGIHAFAVQLREGGVLKKGVSARPINGENEAMTAAGVGVLHFENVTIPVTSLLLPSEIVDGKLVFAGGAATLTSVQALTRQMRLASGALYVGTLKRSLTNIVRYVAQKWMVGPDGRRNYPVFGVQHVQSPLVKLLCTSYVYMTLWRRVLPAFTKPEAQPADYEDEMKLAGTLYFLTDNLSTLKSFADDFMDVHSSLRSTGTCDVLLTVQMRRDGLDHSSLIREVAFKSVVKNVGTTHWGWWLSSCFQSFAALDRFVKNPFYSPRIADLGRHRIFFSHKHYREKKRLRQSREIERRKGGSEHQWYDWVMFRHEQVVHCGEAYMEMFALEVMMDETQACTDPRARKILRDMGWIFALSRQQDRLDYFLTQQMMSPSKSCILSSHLDNIVTVMAPQCVNLVDAFQVPRALRAPCAAEDMESYWTIPGTDTGIQRGDKVLLFGDRKPFGNTKAEQEKMEESREDFDLFHGLAGKQSFAQEK
Protein: Olfactory receptor 2T4 (Olfactory receptor OR1-60) (Q8NH00)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MDNITWMASHTGWSDFILMGLFRQSKHPMANITWMANHTGWSDFILLGLFRQSKHPALLCVVIFVVFLMALSGNAVLILLIHCDAHLHTPMYFFISQLSLMDMAYISVTVPKMLLDQVMGVNKISAPECGMQMFFYVTLAGSEFFLLATMAYDRYVAICHPLRYPVLMNHRVCLFLSSGCWFLGSVDGFTFTPITMTFPFRGSREIHHFFCEVPAVLNLSCSDTSLYEIFMYLCCVLMLLIPVVIISSSYLLILLTIHGMNSAEGRKKAFATCSSHLTVVILFYGAAIYTYMLPSSYHTPEKDMMVSVFYTILTPVVNPLIYSLRNKDVMGALKKMLTVEPAFQKAME
Protein: Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) (O12990)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (By similarity). Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Wholly intracellular, possibly membrane associated. {ECO:0000250}.
Interaction partners:
- Signal transducer and activator of transcription.
- Signal transducer and activator of transcription.
- Suppressor of cytokine signaling 3
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription
- Suppressor of cytokine signaling 3
- Interleukin 10 receptor, beta.
- Cytokine receptor family member b4.
- Gp130 protein
- Interferon gamma receptor 1-like.
Sequence:
MPELAVMDLGRQLCVKMKKQRKAEMTIPTAMKGLEIHFYLADTHQLEFFKACYTAEDLCVEAAKRCRISPLCHNLFALYEESQDLWYAPNHVFKVTDETSIKLHYRMRFYFTNWHGTSEIESPVWRHTLSKQKSVLNSQKTTEGTPLLDAASLDYLFAQGQYDFLRGLSPVRPTQTDEEHHEIENECLGMAVLAITHHAKSNNLPLSGAGAETSYKRFIPDSLNRTIKQRNFLTRIRISNVFKNFLNEFNSKTIQDSNIGLYDLKVKYLSTLETLTQGVGREIFKPKNLKVTGESEGSPAQMLPLGDNGMGYEVQVYGTTGISWRRKPAPNQLILKDKPKSKKIKGDKQWNDKKKDSGWTLFSDFHEITHIVIKDCCVTIYRQDNKTMELDLFYRDAALSFAALVDGYFRLTVDAHHYLCTDVAPSSVVQNLENGCHGPICTEYAIHKLRQEGNEEGTYVLRWSCTEYNFIIMTVVCIELDLCESRPVPQYKNFQIETSPQGYRLYGTDTFRPTLKELLEHLQGQLLRTDNLRFQLRRCCPPQPREISNLLVMTTDREPVPQKKTQVSQLSFDRILKEEIVQGEHLGRGTRTNIYAGILKPKSDDEDDLGGYSQEVKVVLKVLGSGHRDISLAFFETASMMRQISHKHTALLYGVCVRHQENIMVEEFVQYGPLDLFMRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNILVARDGLDGEGGPFIKLSDPGIPITVLSREECVDRIPWIAPECVKDTANLTIAADKWSFGTTLWEICYNGEIPLKDKKLSEKERFYAAQCQLATPDCDELAKLMTHCMTYDPRQRLFFRAIVRDIVMVEKQNPSIQPVPMLEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRNKAHINLKTLHNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPMSVFLKLIGPTHGQMTVTRLVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRIDFKSLIANFQQMLDNL
Protein: RAB GTPase Ypt5, putative (AFU_orthologue AFUA_4G08040) (Q5B6I8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34
- RAB GTPase Vps21/Ypt51, putative
- Vacuolar segregation protein
- Rab GDP dissociation inhibitor
- Vacuolar protein sorting-associated protein 45
- Golgi complex component
- Guanine nucleotide exchange factor Vps9, putative
Sequence:
MASRAAAGARPGARFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTISLDESTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKSWVKELQRQANENIVIALAGNKLDLVTENPDKRAIPTADAEAYAREAGLLFFETSAKTSSNVRELFTAIAKKLPLDQAGPRNMRTAPRPGVDLRPEAPGTQSGGACNC
Protein: Protein Aster-B (GRAM domain-containing protein 1B) (Q80TI0)
Organism: Mus musculus (Mouse)
Function: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000269|PubMed:30220461}.
Interaction partners:
- NPC intracellular cholesterol transporter 1
Sequence:
MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPIEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEVMEGDGSLEKELAIDNIIGEKIEIMAPVTSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFLRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGFVKTFIEKNFWSGLEDYFRHLETELTKTESTYLAEIHRQSPKEKASKSSAVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPDGFHLQSVSKLLLVISCVICFSLVLLVVLNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVLLLDQMKDSLINLQNGIRSRDYTAESDEKRNRYH
Protein: Coiled coil domain containing 88A (D3ZYD7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELAEAPQKSLGHEVNELTSSKLLKLEMENQSLTKTVEELRSTMDSAEGSTSKILKVEKENQRLSKKVEILENEIIQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSGKLSKIEFEKRQMKKELELYKEKGERAEELENELNRLGKENELLQKKITNLKITCEKLETLEQENSELERENRKFKKTLDSFKNLTFQLESLEKENSQLDEENLELRRSVESLKCASMKMAQLQLENKELESEKEQLKKGLELMKASFKKTERLEVSYQGLDTENQRLQKALENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLFKEISVYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLQDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRHELKTVKKNYEALKQRQDEERMVQSSLPISGEDDKWGRESQEATRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESIMKEREDLKSLYDALIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHKDLEDRYNQLLKQKGQLEDLEKMIKVEQEKMLLESKNHEMVAAEYKKLCGDNDRLNHTYSQLLKETEILQTDHKNLKSVLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAAFRSKQLVNNKDTTSFEDVSPQGISDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAANIQSRPQSHSSGDFSLLHDHETWSSSGSSPVQYLKRQTRSSPMLQHKMSETVDSQAHHKMNAGSPGSEVVTLQQFLEESNKLTSIQLKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCTLARSVSGKAPGDFYDRRTAKPEFLRTGPQKTEDAYSISSAGKPTPSTQGKIKLVKETSVLRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLSKDSRLPVSVEPAPPPAGGSSTAASSDTCEHKNSKCIMWSYSRICCIKSIVLPGVCL
Protein: Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Q61189)
Organism: Mus musculus (Mouse)
Function: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54105}. Nucleus {ECO:0000250|UniProtKB:P54105}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P54105}. Note=A small fraction is also associated with the cytoskeleton. {ECO:0000250|UniProtKB:P54105}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D1
- Protein arginine N-methyltransferase 5
- Methylosome protein WDR77
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein G
- Survival motor neuron protein
- Small nuclear ribonucleoprotein F
- U7 snRNA-associated Sm-like protein LSm10
Sequence:
MSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNAKLGEESKEPPSDEDEEDNDDIEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRNYEDGMEVETTPTVAGQFEDADVDH