wanglab/gogpt-training-data huggingface dataset:
Protein: Tricyclene synthase EBOS, chloroplastic (EC 4.2.3.105) ((E)-beta-ocimene synthase) (LjEBOS) (LjEbetaOS) (EC 4.2.3.106) (Terpenoid synthase 2) (LjTPS2) (Q672F7)
Organism: Lotus japonicus (Lotus corniculatus var. japonicus)
Function: Promotes the emission of terpenes volatile organic compounds (VOC) in response to damage mediated by arthropod herbivores (e.g. Tetranychus urticae), probably to attract natural enemies of the herbivores.
Subcellular location: Plastid, chloroplast stroma {ECO:0000250}.
Interaction partners:
Sequence:
MAQSFSMVLNSSFTSHPIFCKPQKLIIRGHNLLQGHRINSPIPCYASTSSTSVSQRKSANYQPNIWNYDYLQSLKLGYADAHYEDMAKKLQEEVRRIIKDDKAEIWTTLELIDDVKRLGLGYHFEKEIREVLNKFLSLNTCVHRSLDKTALCFRLLREYGSDVSADIFERFLDQNGNFKTSLVNNVKGMLSLYEASFLSYEGEQILDKANAFTSFHLKSIHEEDINNILLEQVNHALELPLHRRIHRLEARWYTESYSRRKDANWVLLEAAKLDFNMVQSTLQKDLQEMSRWWKGMGLAPKLSFSRDRLMECFFWTVGMAFEPKYSDLRKGLTKVTSLITTIDDIYDVHGTLEELELFTAIVESWDIKAMQVLPEYMKISFLALYNTVNELAYDALREQGHDILPYLTKAWSDMLKAFLQEAKWCREKHLPKFEHYLNNAWVSVSGVVILTHAYFLLNHNTTKEVLEALENYHALLKRPSIIFRLCNDLGTSTAELQRGEVANSILSCMHENDIGEESAHQHIHSLLNETWKKMNRDRFIHSPFPEPFVEIATNLARIAQCTYQTGDGHGAPDSIAKNRVKSLIIEPIVLNGDIY
Protein: Phenolic glucoside malonyltransferase 1 (BtPMaT1) (EC 2.3.1.-) (EC 2.3.1.116) (P0DUQ3)
Organism: Bemisia tabaci (Sweetpotato whitefly) (Aleurodes tabaci)
Function: Phenolic glucoside malonyltransferase that neutralizes phenolic glycosides in host plants. Catalyzes the transfer of a malonyl group from malonyl-CoA to the phenolic glycosides, leading to their detoxification. Phenolic glycosides, which are among the most abundant plant secondary metabolites, act as plant defense compounds: they strongly affect growth, development and behavior of insect herbivores. Has malonyltransferase activity against flavonoids kaempferol 3-O-glucoside, kaempferol 7-O-glucoside, isoquercetin (quercetin 3-O-beta-D-glucopyranoside), apigetrin (apigenin 7-O-beta-D-glucoside) and prunin (naringenin 7-O-beta-D-glucoside). Also has activity toward non-flavonoid rhaponticin, but with lower efficiency.
Interaction partners:
Sequence:
MSISSSVAVLNVVQVSPPTAPVNNAFQDRISLTHFDLLALRAPPNQRLFFYETHLPISAFAETVIPKLRDSLSLTLQNFRPLAGTLIWSLHSDEPYIRIKDDDSVPLTIAETDADPQKLFDDPFQQETDLQQLLPPLRVSETEASLLALQITLFPSGDICLGITFHHAAQDGASLALFLKSWAHICRHGDDPPLPQNLIPIFDRDFIDDPKNIKQLFLDHLLTPLTPGGPRNRSVKPMEKPFNDRMHGSFRLTVDDIENLRRRITSLQVQNTSQEPPVRMSTVVVTCAYVLTCFVKAGLTKKHVRFILPADLRKRLQPPVPDNYYGNCVFGCTVDMSSDDLAGQDGLVVAAKTISSVVSELDANDHRTFFENFLLNNTISQEETKVGVGGSIYFSLDEKDFGWGGPKHLKNVPPWPNHIYLAERRDGDKGVDFCLMLAKQEMAEFESKFLDDLKLLEKRSC
Protein: Elongation of fatty acids protein (EC 2.3.1.-) (Q4QFS0)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Putative stearic acid desaturase
- Putative fatty-acid desaturase
- Fatty acid elongase 6
- Polyprenol reductase
- Elongation of fatty acids protein
- very-long-chain
- Delta-12 fatty acid desaturase
- beta-ketoacyl-[acyl-carrier-protein] synthase I
- Uncharacterized protein
Sequence:
MQWLDNYGDHHYDGHAVQMWLASNVDVCAYIAGAYLAFVFTGPRLMEALFHGKPPTGIKKAWALWNLGLSVFSLYGWLRVGPPLLRRLMHDGLHNTLCTFHEDEFYTTKVGFAIGMFAISKVPEFIDTVFLLMSGVKLAFLSWFHHVTTYLFAWYSYQQGTSIFICAAAMNYFVHSIMYMYFALSEAGFKKLVKPFAMYITLLQITQMVGGLFVSGYVLVQKLTEGAGNPCSGTSMSAARTQLVIYIFNFYLFSEMFIKAYVLPRKAGAALRRPSPSKRS
Protein: Tumor necrosis factor ligand superfamily member 14 (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form] (Q9QYH9)
Organism: Mus musculus (Mouse)
Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted {ECO:0000250}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 3
- Tumor necrosis factor receptor superfamily member 14
- CD160 antigen
- Lymphotoxin-beta
- Tumor necrosis factor receptor superfamily member 5
- Tumor necrosis factor receptor superfamily member 1B
- Tumor necrosis factor ligand superfamily member 13B
- CD40 ligand
- Tumor necrosis factor ligand superfamily member 12
Sequence:
MESVVQPSVFVVDGQTDIPFRRLEQNHRRRRCGTVQVSLALVLLLGAGLATQGWFLLRLHQRLGDIVAHLPDGGKGSWEKLIQDQRSHQANPAAHLTGANASLIGIGGPLLWETRLGLAFLRGLTYHDGALVTMEPGYYYVYSKVQLSGVGCPQGLANGLPITHGLYKRTSRYPKELELLVSRRSPCGRANSSRVWWDSSFLGGVVHLEAGEEVVVRVPGNRLVRPRDGTRSYFGAFMV
Protein: Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Ubiquitin thiollesterase 6) (Ubiquitin-specific-processing protease 6) (Q92353)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Subcellular location: Nucleus {ECO:0000269|PubMed:15533439, ECO:0000269|PubMed:16823372}.
Interaction partners:
- 26S proteasome regulatory subunit 4 homolog
- Probable 26S proteasome regulatory subunit rpn9
- Probable 26S proteasome regulatory subunit rpn6
- 26S proteasome regulatory subunit rpn10
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit rpn7
Sequence:
MMIPIAIRWQGKKYDLEIEPNETGSTLKHQLYSLTQVPPERQKVIVKGGQLKDDVLLGSVGIKPNATLLMMGTAGELPTAMPIPAVESVEQEESEDDGYPSGLINLGNTCYMNSTVQMLRAIPELSDAVSQFNSSGGLVAEYRTLLNSMQSNAPVTPMRFLQSLRMEYPQFAEMSRETGGYAQQDAEECWSFLLSVLQRSLSSEWVQKNMAGKLLSTMKCDENEVQEQPSISHDTFLSLPCHISMHTSYMTQGILEGLTQKISKHSDVLNRDAMYSKISRISRLPNYLTVNFVRFYWKASIGKKAKILRKVKFPFELDAVEFCTPELSQKLIPVRDKLREIEKNDEEHERAAKRIKIQPSEDEKEAEAECRLTQVATCQSLVDPELADDEGANPTGLYDLVGVLSHAGASASSGHYQAWIRNSNNRAEWFRFNDAKVSIVPAEKIETLDGGGEADSAYILLYKAKDIA
Protein: Homeobox protein Hox-A2 (Homeobox protein Hox-1.11) (P31246)
Organism: Rattus norvegicus (Rat)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRQSAGAGGRPKSSPAGSRGSPVPARALQPPEYPWMKEKKAAKKTALPPAAASTGPACLGHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKFKNLEDSDKVEEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQTFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVPSLQDFNVFSTDSCLQLSDALSPSLPGSLGSPVDISADSFDFFTDTLTTIDLQHLNY
Protein: Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Q8VCC8)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity).
Subcellular location: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Adenylate cyclase type 5
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Adenylate cyclase type 1
- Beta-arrestin-2
- Adenylate cyclase type 6
- Adenylate cyclase type 8
- Beta-arrestin-1
- Adenylate cyclase type 9
- Mitogen-activated protein kinase 7
Sequence:
MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEDSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRKYHLRLYRHCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPEPTGTQDVEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQEHSTYICNKRQQILRLVGRWVALYSPMLHSDPVATSFLQKLSDLVSRDARLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWLPNQEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERLFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQEHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDVTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
Protein: Leucine-rich repeat protein (LRRP) (Q584H4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Uncharacterized protein
- Anaphase-promoting complex subunit 4 WD40 domain-containing protein
- Protein phosphatase 2C, putative
- Ubiquitin-conjugating enzyme E2, putative
- RRM domain-containing protein
Sequence:
MGSDVDLRNETEAKNSNHFGKRTNLDRSSVKRQRDGKGGDSLHRACPNAADVQRAVACGGGEAKDAADGGKLSRTRVGRLSDPVYRIMHMLPRSDVLEVVKCRFGPEECQRAASYFDKSFMENPLRHLRLQIGCDRATGLNLFFPKLQHHRGTLRHLDLSRNRLDEDDVATLVQVLDIRRDETNNNSSALEVLDLSYNRHIGDRGGVMLLSALRGNDRIRAVILKGISLSDAGAFGIAALLPQRPKPLLCGEGGGCDYPLSSSASVSQNPTFFLNLNENIIGVKGIGALGKGIPSYVSVTASRQYPSFSSRRSARVIR
Protein: Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) (Q8N6F7)
Organism: Homo sapiens (Human)
Function: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Subcellular location: Cytoplasm. Cell membrane {ECO:0000269|PubMed:31570756}. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
Interaction partners:
Sequence:
MGNSLLRENRRQQNTQEMPWNVRMQSPKQRTSRCWDHHIAEGCFCLPWKKILIFEKRQDSQNENERMSSTPIQDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTDPRHARSPEDEYELLMPHRISSHFLQQPRPLMAPSETQFSHL
Protein: Digalactosyldiacylglycerol synthase 1, chloroplastic (EC 2.4.1.241) (Q9S7D1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha-glycosidic linkages. Responsible for the final assembly of galactolipids in photosynthetic membranes. Digalactosyldiacylglycerol (DGDG) provides stability to the photosystem I (PSI) complex, especially to the PsaA, PsaB, PsaC, PsaL and PsaH subunits.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:11429410}.
Interaction partners:
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
- Monogalactosyldiacylglycerol synthase 2, chloroplastic
- Monogalactosyldiacylglycerol synthase 1, chloroplastic
- Galactolipid galactosyltransferase SFR2, chloroplastic
- Digalactosyldiacylglycerol synthase 2, chloroplastic
- Sulfoquinovosyl transferase SQD2
- UDP-sulfoquinovose synthase, chloroplastic
- Alpha/beta-Hydrolases superfamily protein
- Protein DGS1, mitochondrial
- Phospholipase A1-Igamma3, chloroplastic
Sequence:
MVKETLIPPSSTSMTTGTSSSSSLSMTLSSTNALSFLSKGWREVWDSADADLQLMRDRANSVKNLASTFDREIENFLNNSARSAFPVGSPSASSFSNEIGIMKKLQPKISEFRRVYSAPEISRKVMERWGPARAKLGMDLSAIKKAIVSEMELDERQGVLEMSRLRRRRNSDRVRFTEFFAEAERDGEAYFGDWEPIRSLKSRFKEFEKRSSLEILSGFKNSEFVEKLKTSFKSIYKETDEAKDVPPLDVPELLACLVRQSEPFLDQIGVRKDTCDRIVESLCKCKSQQLWRLPSAQASDLIENDNHGVDLDMRIASVLQSTGHHYDGGFWTDFVKPETPENKRHVAIVTTASLPWMTGTAVNPLFRAAYLAKAAKQSVTLVVPWLCESDQELVYPNNLTFSSPEEQESYIRKWLEERIGFKADFKISFYPGKFSKERRSIFPAGDTSQFISSKDADIAILEEPEHLNWYYHGKRWTDKFNHVVGIVHTNYLEYIKREKNGALQAFFVNHVNNWVTRAYCDKVLRLSAATQDLPKSVVCNVHGVNPKFLMIGEKIAEERSRGEQAFSKGAYFLGKMVWAKGYRELIDLMAKHKSELGSFNLDVYGNGEDAVEVQRAAKKHDLNLNFLKGRDHADDALHKYKVFINPSISDVLCTATAEALAMGKFVVCADHPSNEFFRSFPNCLTYKTSEDFVSKVQEAMTKEPLPLTPEQMYNLSWEAATQRFMEYSDLDKILNNGEGGRKMRKSRSVPSFNEVVDGGLAFSHYVLTGNDFLRLCTGATPRTKDYDNQHCKDLNLVPPHVHKPIFGW
Protein: DNA polymerase epsilon subunit 3 (Chromatin accessibility complex 14kD protein) (Histone-fold protein CHRAC subunit) (Q9V444)
Organism: Drosophila melanogaster (Fruit fly)
Function: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf. Has a role in DNA damage response by preventing cid mislocalization to chromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:10856248, ECO:0000269|PubMed:11447119, ECO:0000269|PubMed:18327268, ECO:0000269|PubMed:24703848}.
Interaction partners:
- ATP-dependent chromatin assembly factor large subunit
- Chromatin-remodeling complex ATPase chain Iswi
- Chromatin accessibility complex 16kD protein
- DNA polymerase epsilon catalytic subunit 1
- DNA polymerase epsilon subunit 4
- DNA polymerase epsilon subunit 2
- Protein Dr1
- Ada2a-containing complex component 2
- Molybdopterin synthase catalytic subunit
- Ada2a-containing complex component 1
Sequence:
MVERIEDLNLPNAVIGRLIKEALPESASVSKEARAAIARAASVFAIFVTSSSTALAHKQNHKTITAKDILQTLTELDFESFVPSLTQDLEVYRKVVKEKKESKASKKDSNTAENANASATATAEEAPE
Protein: Protein CDC73 homolog (Protein PLANT HOMOLOGOUS TO PARAFIBROMIN) (Q9LJ87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus.
Subcellular location: Nucleus {ECO:0000269|PubMed:20363855, ECO:0000269|PubMed:20463090}.
Interaction partners:
- Protein LEO1 homolog
- Protein CTR9 homolog
- Protein PAF1 homolog
- FACT complex subunit SSRP1
- Protein RTF1 homolog
- FACT complex subunit SPT16
- FACT complex subunit
- WD repeat-containing protein VIP3
- Transcription elongation factor SPT6 homolog
- DNA-directed RNA polymerases II, IV and V subunit 11
Sequence:
MDPLSVLKEFTIRGDIDKIERVGANYRFGSEYSFPCATETAYRSKSGSLYTLEALVHYVKNQQLKHGEYMQSTVKNSVPAVTLPDRKPLLDYLTGRVASSDSIDFLLLQQQNAQSQKQNEEYRPDQDNSAFVSRENAIADMEVEDFGKSGEDVDYIMLIRSNERPLKSRDAILQCKNRDFYSVLVNSTKREEERQRIESHQRKDGLVAKSRLMGAEERGIVGFSSGGGDDNGYDANPKSKLHFKAGKIGEGVPIILVPSAFQTLITIYNVKEFLEDGVYIPNDVKAKEMKGLKPDCITVQKKFSRDRERVVTAYEVRDKPSALKPDDWDRVVAVFVLGKDWQFKDWPFKDHVEIFNKIIGFFLRFEDDSIESAKTVKQWNVKIISISKNKRHQDRAAALEVWEKLEEFVRSRSHS
Protein: Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) (Q02153)
Organism: Homo sapiens (Human)
Function: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P16068}.
Interaction partners:
- Guanylate cyclase soluble subunit alpha-1
- Guanylate cyclase soluble subunit alpha-2
- cGMP-dependent protein kinase 1
- cGMP-dependent protein kinase 2
- Nitric oxide synthase 1
- Inosine triphosphate pyrophosphatase
- Pyruvate kinase PKLR
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Pyruvate kinase PKM
Sequence:
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
Protein: Dehydrodolichyl diphosphate synthase CPT5, chloroplastic (EC 2.5.1.87) (Cis-prenyltransferase 5) (SlCPT5) (K7X479)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:23134568}.
Interaction partners:
Sequence:
MAFSFQLQQVFPFPVKFCSQPKSIKLQIFPNLTKRLPIHPLASAQNNATSNIDHNYIAMDESSINEEEVPLPTELSRELMPKHIAVIMDGNRRWAKRRGLPVALGYAAGIRVLRNFVKLSYNWGISALTLFAFSSENWFRPKAEVDLLMGLFDKVLKDELENLARTGIRLSIIGDASQLPKSLQDLIDKAVMATKANSRLHILVAINYSGQYDVVQACQTIAQRVKDGNIEPEDINSLLVEQELQTKCTEFPSPDLLIRTSGELRLSNFLLWQLAYTELFFSHSQWPDFGEAEFLEALCSFQQRQRRYGGQSS
Protein: DUF724 domain-containing protein 7 (AtDUF7) (ABAP1-interacting protein 1) (Q8H0V4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a link between DNA replication, transcription and chromatin remodeling during flower development. May participate in the repression of LHP1-targeted genes during flower development by direct interaction with LHP1. May be involved in the polar growth of plant cells via transportation of RNAs (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:19795213, ECO:0000269|PubMed:26538092}.
Interaction partners:
- ARMADILLO BTB ARABIDOPSIS PROTEIN 1
- CDT1-like protein b
- Protein EMSY-LIKE 3
- Vacuolar protein sorting-associated protein 53 A
- Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 2
- Proliferating cell nuclear antigen 2
Sequence:
MLLTTGRKEKLSVSKGSEIEISSQEYEYGSGNVWYCVILEENLAKSKRKKLSVRHLDPLLKYDYSPPLIKTTVHRFMRPVPPPDPFPEVDFEEGDVVDAAYKGGWCSGSVVKVLGNRRFLVYLRFQPDVIELLRKDLRPHFVWKDEEWFRCEKQQLIESDFSAGKSVEVRTKVDKLGDVWAPAMVIKEDEDGTMLVKLKTLKEEEVNCTKISVSYSEIRPSPLPIGLRDYKLMENVDALVESGWCPGVVSKVLAGKRYAVDLGPNRESKEFSRLQLRPSIEWKDGIWHRKEKVSGSEESSHAVEETAASTRIRITVRTALKEKKALGTGINVRTTRSSSGAMHNPLPASFNGGDVAEAGRVSVTVNETPLFETAALSGELGNSLADVVMNESAPVTSQPEIAAPKEFHPSVVLGVAAAVKTQGKTTPKKKLQAMKNQKSSTNDSVGEKVSVNKRKRGQPRKFIVAEPKQKIGVSGNNSKAATIEHADMTDDDRPLASWVHTGNSSSGQSVSRTPDIGLNTVVEKHVDIVETPPGRESTMVLPFVKKSQLWKVLESMEVFKVVPQSPHFSPLLESEEECREGDAIGRMVMFSSLLEKVNNLQVDDPISSINRIDECFLKLEKHGFNVTTPRSRIAKILSIKERQTCALEELKAVEEKITENDNKRRKYEEDIVELQRQEVLMKEAKVTLDNEIARMQSQAAVLDQEVQNVDHEFQAILAAPWK
Protein: Protein cornichon homolog 2 (CNIH-2) (Cornichon family AMPA receptor auxiliary protein 2) (Cornichon-like protein) (Q401C0)
Organism: Gallus gallus (Chicken)
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs) (By similarity). Plays an important role in the proper development of cranial nerves by facilitating the secretion of HBEGF.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glutamate receptor
- Glutamate receptor
- Germ cell-specific gene 1-like protein
- Receptor expression-enhancing protein.
- Gamma-tubulin complex component
- Glutamate receptor
- Uncharacterized protein.
- Uncharacterized protein.
- Calcium voltage-gated channel auxiliary subunit gamma 7.
- Shisa family member 9.
Sequence:
MAFTFAAFCYMLTLVLCASLIFFVIWHIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYCIHGLFCLMFLCAAEWVTLGLNLPLLLYHLWRYFHRPSDGSEGLFDAVSIMDADILGYCQKEAWCKLAFYLLSFFYYLYSMVYTLVSF
Protein: Protein NRD1 (P53617)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear polyadenylated RNA-binding protein 3
- Helicase SEN1
- Poly
- DNA-directed RNA polymerase II subunit RPB1
- Exosome complex exonuclease RRP6
- Nuclear cap-binding protein subunit 2
- mRNA cap guanine-N
- Protein PCF11
- Nuclear cap-binding protein complex subunit 1
- Protein AIR2
Sequence:
MQQDDDFQNFVATLESFKDLKSGISGSRIKKLTTYALDHIDIESKIISLIIDYSRLCPDSHKLGSLYIIDSIGRAYLDETRSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLNAIRSKCFAMDISNNTANTASQQLSLDPKQRSKQILSNLKKSPPLNLNISLPTDLTSTDPAKQQAALFQVIAALQKHFKTLPSHTSVGTVAPPQAHTITEYGSRRERERERERYNSRRNRSRSPPAPFSQPSTGRKDRYPSVAQDQYSIGAPNTTFGTNNHHLYPDELNVSNNPHYRPKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKPFAEVQSVILNNSRKHAFVKVYSRHEAENVLQNFNKDGALPLRTRWGVGFGPRDCCDYQHGYSIIPMHRLTDADKKWSVSAQWGGTSGQPLVTGIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGKPNKSGSISSISPVPYGNAPLASPPPQQYVQPMMQQPYGYAPNQPLPSQGPAAAAPPVPQQQFDPTAQLNSLMNMLNQQQQQQQQS
Protein: Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) (A0PK84)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N966}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8N966}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein FAM163B
- Palmitoyltransferase ZDHHC23
- Zinc finger C2HC domain-containing protein 1B
- Palmitoyltransferase ZDHHC11
Sequence:
MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYVLVIQNSPDDLGTCQGTMSQRPQCPPPSTHFCRVCSRVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGMAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK
Protein: DM domain-containing protein mab-23 (G5ECK3)
Organism: Caenorhabditis elegans
Function: Probable transcription factor that plays a role in the development of the dopaminergic neurons of the male-specific genital sensilla (simple sense organs) known as rays, by negatively regulating the activity of the transcription factor ast-1. Involved in male mating behavior, probably as a result of a role in the differentiation of male-specific diagonal muscles. Required for development of the male proctodeum. May be dispensable in hermaphrodites.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- Protein male abnormal 3
- DM domain-containing protein.
- Doublesex- and mab-3-related transcription factor dmd-5
Sequence:
MPKEQYMCQLCANHGIFNQPKKGHKQKCPYRTCPCSLCALNTKRRALDQIERQLKHTNEPMTGQTATSMASPTPECPLSPTTPKMTPHTPTSGKDTFRNSISSSNMAFTVQLPATITKKELKLLRRDDTPLQNSLERPFPRSIDEAIETIKKEKMSSIFHSAEMLAVGESATSLI