wanglab/gogpt-training-data huggingface dataset:
Protein: AP-2 complex subunit beta (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Clathrin assembly protein large beta chain) (O43005)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).
Subcellular location: Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Interaction partners:
- AP-2 complex subunit alpha
- AP-1 complex subunit gamma-1
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
- Probable clathrin heavy chain
- AP-1 complex subunit mu-1
- AP-1 complex subunit sigma-1
- AP-3 complex subunit delta
- Clathrin light chain
- AP-3 complex subunit beta
Sequence:
MSSSSSHFSSTAADLLAVFSSDNKDKSANKRISALKKAIAGISYGYDMSSLFPSVISSMESNNLELKKLCYLYLKIYASVKPTEAKRAVKLILNDIYSSNPMIRSLALRTLTSVNIKNFWVAAMDPIVRLLDDTDPYVRKTAAIGIAKLYSYDKKMVESSGLIDHLKEMLSDESSVVVANSLAALMNIVNSSTGFKLTFSREISNKLVKSLTDCSEWLQVAILDALIFYVPQKPGEAESFAERISPWLQHGNAAVCMGAVKVILYLTNYMKDDNRVKEYFMKTQPPLVTLLARKSSATQYVILRNIQIILEQCPEMFANDIHFFYCNFDDPIYVKLEKLDILTKIADIHNLDQILPEFVEYASEIDVELVRKSVKCIGYLAIKIEERKNDCIDSLIELMNTKVTYVIQEAVIVIRDILRKYPGSYKSLVPILYENLDSLDEPDAKSAVIWILGQYAEEIEDSITLLNDYLKGFFDEPLEIQLTLLTAVIKVFLKKPTAAADMVTNVLQWCTDEVNDPDLRDRGIIYSRMLSANPELAKKVILANMPPVNVGTGMYDPDTTEQLMLNISTLSSIYHKPPNRFVKGAQVAYCEPSPVLRLRTRDSNPSNTDSRESNHKKYNHFHQKSQTRRVMEQYDRNSWNPSPFSDESNSNTFSGKFDSADQENLGMPMTPETHLMD
Protein: LD27203p (Vajk4) (Q7K0W4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RH73259p
- Cilia- and flagella-associated protein 45
- Uncharacterized protein, isoform E
Sequence:
MRMFVLPCLAVCVALAHCGGAVEDKKAEGDGKTVEKRGLHLGDYHHYQPHHEHIKTVTIEKKIPVPYTVTKHVPYTVEKKIPYEVKVDVPQPYIVEKKVPVHVKEYVKVPVHVPKPYEVIKKIPYEVKVPVDKPYEVKVPVPQPYEVIKKIPYEVKVPVPQPYEVIKKVPHEVKVEVPVPKPYEVIKKVPYEVKYEVEKPYDVEVPKPYDVEVEKPYTVVVEKKVPYEVKVPVDKPYKVEVEKPYPVHVKVPVPQPYTVEKKVPYTVEKPVPYEVKVPIEKPIPVYTEVKVPIHKEIPVPEKYHVEVPIFKHHQEDHHDYHSHGHGHY
Protein: Fibronectin type-III domain-containing protein 3A (Q8BX90)
Organism: Mus musculus (Mouse)
Function: Mediates spermatid-Sertoli adhesion during spermatogenesis.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAEHPPLLDTAQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQSPEFHPGGHTVIHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMATQYMPQYQSSQVYADVDAHSTHGRSNFRDERSSKTYERLQKKLKDRQGTQKDKMSSPPPSPQKCPSPISEHNGLIKGQNASGGNTGSARNRSGRGRSCTQVDPEMEEKDEETKAFEAFLSNIVKPVASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKEGKYRSVYIGEETSVTLNDLKPATDYHAKVQAESNSIKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAKNDYGVSDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFSTCPDKPGVPVKPSVKGKIHSHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTTREHLCDRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPQVDGGSPISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITTAPGPPDQCRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGVEGSMQMCYCGPGLSCELKGLSPATTYYCRVQAMSVVGAGPFSEVVACVTPPSVPAIVTCLQEISDDDIEYPHYSPSTCLAISWKEPYDHGSEILAYSIDLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLPPDPPRLECVAFNHQNLKLKWGEGTPKTLSTDAVQYHLQMEDRNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKSLPAALKAPKIEKINDHICEITWEYLQPMKGDPVIYNLQVMVGKDSEFKQIYKGPDTSFRYSSLQLNCEYRFRVCAIRQCQDPTGHQDLVGPYSTTVFFISQRTEPPASSNKDSVDSARTRRTLSDEQCAAVILVVFAFFSILIAFIIQYFVIK
Protein: RE71183p (Q6AWQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMFTGTNQQQDTRFSDKEKKLMKQMKFGDCLNKRVDMSKVKLDVLRPWISKKITDILHIEDDVVVEFVYNQLEEEKYPCPKKMQINMTGFLNGRNARQFMGELWALLLSAQESDSGIPAEFIQQKKDEILKREEEQRQRDRSRSRSRSRSQRDSSRRDRQRDRSKSKSRSRSRSMKPANNNGSVPSAAREAAANAAAKIRKRGSSSAARPGSRERRSSRRPRSRSRSRSRTAGKKTGSVEPAPAKTVNGRHSTDKSSPVPPASKNKSRSRSHSRSRSPRSRSRSPSAKRSRSRSSSRRSRRRGRSSSISLSPERNQDQFEHRRNKNSVQNKRQYRNNRGDSASSMERGNDRGRQFGGGGGGRRGGRRFSPRGRSPMRQDNGGGNGGNRFQRSNSRRRSRSRRLSRSPMRYSRSPRRFNNRRRSPMMNFRGGGRGGGRGGGHRQMWQHRGGSPNFRGGGRIHWQARHSPGGGGRGGGGGMGRFDRRQSPQQNRYNRDHRQSPMQQNQPFRKQFSPHQGPGRRFSSPQQRRNSRDRRPNSRERRSSPGGGGGHMNRWDNPPPARNRRSSSGSSAGGRQQRQRSASPPEKRRSSHSRSRSLSRNRSRSRSSSQHSRKRESPIGRSSVEYAGPAVNTIDLCREEQQRKNKPETIIVLDEGPAVRSSYASLSRTPSPFLKPHERLAAAKAAAAASAAVPKKSRDQSQSSSSDSSAESDDSEEQPRRKKQPTNMETSKGKKEKVRRSSESSTSSEQSDDEDNSSGDERLKKKLQQRKSKEAAALKGKEKEHEKEKDKRRSDKKSKRGAISSGDEESTSSRKRGHKKTRRDEAGDNSDSEDEHVPKKKRKKAKKPADSSDSDSEASSKRKKHKKHKKHSKKSKKHKKHKRKCSAGKSRADSSSQGSSDEDEQLPHSVAAKRNGNAGKLALLLPGASGAGVTNEDLEKQLRERALKSMKKLD
Protein: Integral membrane protein (AFU_orthologue AFUA_2G12640) (Q5B7U3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAALYRAILLLRSDHGLDGEHHLVPRQSHTVETLDGSTKAGFIAMGICGLVSFIATLSLLLFLTYRFIFWKRYYKRPLAHNQYVVLIYQLLLVDLQQATAFLLCLHWVTKGAVYYPSAACILQGWWIQTADPGSGLFVIAIAMHTGAVVLRGRQLSFRAFVACVIGLWAFILVLGFITVGLYGSKTFVISEAAWCWLSPEHENERLWGHYLWIFLAEFGTVVLYGIMFFYLRRRMVHAAKLRPNHQDSLKRLNRVVIYMVIYPFAYILLSLPLAAGRMSSARHVIPSRQYFAAAGSLMALSGLADAAVYTLTRRQLLLDTDLSQSDGPYNRYAYSGSHTYHTQVTSTTGGRERKRGRFRKGMQTLNETIQDDRDDSTEEIVKGGRNDSGDVEMVNYTGHGVYQETTIEITHEVADPREFPQRERHSG
Protein: Glutathione S-transferase GstB (EC 2.5.1.18) (P0ACA7)
Organism: Escherichia coli (strain K12)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the glutathione-dependent dehalogenation of bromoacetate.
Interaction partners:
- Glutathione S-transferase GstA
- Glutathione S-transferase YfcF
- Glutathione-specific gamma-glutamylcyclotransferase
- Thioredoxin/glutathione peroxidase BtuE
- Glutathione reductase
- Glutathione synthetase
- Glutathione hydrolase proenzyme
- Bifunctional glutathionylspermidine synthetase/amidase
- Maltose/maltodextrin-binding periplasmic protein
Sequence:
MITLWGRNNSTNVKKVLLTLEELELPYEQILAGREFGINHDADFLAMNPNGLVPLLRDDESDLILWESNAIVRYLAAQYGQKRLWIDSPARRAEAEKWMDWANQTLSNAHRGILMGLVRTPPEERDQAAIDASCKECDALFALLDAELAKVKWFSGDEFGVGDIAIAPFIYNLFNVGLTWTPRPNLQRWYQQLTERPAVRKVVMIPVS
Protein: Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (A0A060W6G8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ig-like domain-containing protein
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Endothelin-3
- Neuropeptide Y
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Motilin/ghrelin-associated peptide domain-containing protein
- Guanine nucleotide-binding protein subunit alpha-13
- Uncharacterized protein
Sequence:
MGCDNLTNSNGTLPARLPYTVQTSVPLTILVGILILLTVFGNVLVVIAVFTSRALRAPQNLFLVSLACADILVATLVMPFSLANELMGYWYFGQVWCEIYLALDVLFCTSSITHLCAISLDRYWSVTQAIEYNSKRTPRRIKCIVLFVWVLAAIISFPPLISMEKEGAKEEGPTCKINEEKWYIIFSSTASFFAPCVIMILVYVRIYQVAKKRTRAPTGERRRENNNPEKRNKRGRDGVEEDAEVNGLNMEEECSSSDGNENQCSIKMKRSKEKTKVCQVKLAEPSPKGDDAQQYVKVSRWKGRQNREKRFTFVLAVVMGVFVVCWFPFFFTYTLTAICDSCCVPESLFNFFFWFGYCNSSLNPVIYTIFNNDFRRSFKKILCKRDRRGL
Protein: Ganodermin (P84995)
Organism: Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus)
Function: Has antifungal activity against B.cinera, F.oxysporum and P.piricola with IC(50) values of 15.2 uM, 12.4 uM and 18.1 uM, respectively. Lacks hemagglutinating activity towards rabbit erythrocytes. Lacks deoxyribonuclease, ribonuclease and protease inhibitory activities.
Interaction partners:
Sequence:
AGETHTVMINHAGRGAPKLVVGGKKLS
Protein: Kinase suppressor of ras 1 (A8MY87)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
HSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPDISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL
Protein: Probable indole-3-pyruvate monooxygenase YUCCA8 (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA8) (Q9SVU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin biosynthesis. Belongs to the set of redundant YUCCA genes probably responsible for auxin biosynthesis in roots.
Interaction partners:
- L-tryptophan--pyruvate aminotransferase 1
- Aromatic aminotransferase ISS1
- Tryptophan aminotransferase-related protein 2
- Tryptophan aminotransferase-related protein 1
- Auxin-responsive protein IAA29
- Transcription factor PIF4
- Amidase 1
- Auxin-responsive protein IAA19
- Transcription factor PIF7
- Transcription factor PIF5
Sequence:
MENMFRLMDQDQDLTNNRCIWVNGPVIVGAGPSGLATAACLHEQNVPFVVLERADCIASLWQKRTYDRLKLHLPKQFCQLPKMPFPEDFPEYPTKRQFIDYLESYATRFEINPKFNECVQTARFDETSGLWRVKTVSKSESTQTEVEYICRWLVVATGENAERVMPEIDGLSEFSGEVIHACDYKSGEKFAGKKVLVVGCGNSGMEVSLDLANHFAKPSMVVRSSLHVMPREVMGKSTFELAMKMLRWFPLWLVDKILLVLSWMVLGNIEKYGLKRPEMGPMELKSVKGKTPVLDIGAIEKIRLGKINVVPGIKRFNGNKVELVNGEQLDVDSVVLATGYRSNVPYWLQENEFFAKNGFPKTVADNNGWKGRTGLYAVGFTRKGLSGASMDAVKIAQDIGSVWQLETKQPTKRSRGSLRRCISQQF
Protein: Polyhedral envelope-associated phosphoprotein (PE) (Polyhedral calyx protein) (phosphoprotein pp34) (P24728)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Major component of the polyhedra envelope.
Subcellular location: Virion membrane {ECO:0000269|PubMed:3279702}. Host cytoplasm {ECO:0000269|PubMed:2109589}. Host nucleus {ECO:0000269|PubMed:2109589}. Note=Found associated with fibrillar structures present in the host nucleus and cytoplasm of infected cells. {ECO:0000269|PubMed:2109589}.
Interaction partners:
Sequence:
MKPTNNVMFDDASVLWIDTDYIYQNLKMPLQAFQQLLFTIPSKHRKMINDAGGSCHNTVKYMVDIYGAAVLVLRTPCSFADQLLSTFIANNYLCYFYRRRRSRSRSRSRSRSRSPHCRPRSRSPHCRPRSRSRSRSRSRSRSSSPRRGRRQIFDALEKIRHQNDMLMSNVNQINLNQTNQFLELSNMMTGVRNQNVQLLAALETAKDVILTRLNTLLAEITDSLPDLTSMLDKLAEQLLDAINTVQQTCATS
Protein: Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF-like (NPAF)] (Q9WVA9)
Organism: Rattus norvegicus (Rat)
Function: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF and SF potentiate and sensitize ASIC2 and ASIC3 channels.
Subcellular location: Secreted.
Interaction partners:
- Neuropeptide FF receptor 2
- Neuropeptide FF receptor 1
- Prolactin-releasing peptide
- Pro-FMRFamide-related neuropeptide VF
- Orexigenic neuropeptide QRFP
- Prolactin-releasing peptide receptor
- Pro-neuropeptide Y
Sequence:
MDSKWAAVLLLLLLLRNWGHAEEAGSWGEDQVFAEEDKGPHPSQYAHTPDRIQTPGSLMRVLLQAMERPRRNPAFLFQPQRFGRNAWGPWSKEQLSPQAREFWSLAAPQRFGKK
Protein: Hepatoma-derived growth factor-related protein 3 (HRP-3) (Q9JMG7)
Organism: Mus musculus (Mouse)
Function: Enhances DNA synthesis and may play a role in cell proliferation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQTIQQQSSSETEGEGGNTADASSEEEGDRVEDGKGKRKNEKGGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSSEGGDAGNDTRNTTADLQKAGEGT
Protein: Transcription factor E2F4 (E2F-4) (Q16254)
Organism: Homo sapiens (Human)
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor Dp-2
- Mothers against decapentaplegic homolog 3
- Retinoblastoma-associated protein
- Transcription factor Dp-1
- Retinoblastoma-like protein 2
- Retinoblastoma-like protein 1
- Mothers against decapentaplegic homolog 4
- Histone deacetylase 1
- Protein lin-9 homolog
- Transcription factor E2F5
Sequence:
MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEASRPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQSSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTSFEPIKADPTGVLELPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL
Protein: Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (A0A1N7SYS3)
Organism: Caenorhabditis elegans
Function: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9P0S2}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9P0S2}.
Interaction partners:
- Cytochrome OXidase assembly protein
- Cytochrome c oxidase subunit 2
- asparaginase
- Glutamyl-tRNA
- Probable peptidyl-tRNA hydrolase 2
Sequence:
MSRLKFVRVGLPFFAIVLGSAYGLHFFQQVRFDFRKIKQEDDNLELLRSDLTRSGLRLREGVTVESVYKEVAELDTDNWENIRGPRDTEDLTDYNLIKKQQQEASRKVRELKSNV
Protein: Rac GTPase activating protein 1 (F8VV39)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDT
Protein: E3 ubiquitin-protein ligase SGR9, amyloplastic (EC 2.3.2.27) (Protein SHOOT GRAVITROPISM 9) (RING-type E3 ubiquitin transferase SGR9) (Q8GXF8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Modulates amyloplast dynamics and sedimentation in statocytes during inflorescence, hypocotyl and root gravitropism, probably by regulating amyloplast interaction with actin filaments (AFs) in endodermal cells.
Subcellular location: Plastid, amyloplast {ECO:0000269|PubMed:21602290}. Note=Localized at amyloplasts within gravity-sensing cells.
Interaction partners:
- Phospholipase SGR2
- Vesicle transport v-SNARE 11
- Actin-related protein 3
- Probable aspartyl protease At4g16563
- U-box domain-containing protein 45
- At1g14330/F14L17_7
- BTB/POZ domain-containing protein At2g30600
- U-box domain-containing protein 29
- Probable CCR4-associated factor 1 homolog 5
- Protein SHOOT GRAVITROPISM 6
Sequence:
MEDENTTIIMASLSALSPSHLTNLTHSILSISHHHRRRLGAVLSSPTLFSLTLRHLLSLSLPDKTHLIANHLLSLLHPLLIHRKHHSSYAVTMKLRDLDAVVLLLFLCETHQLHPDVLEASADNWREILGNTYSNNMLSNNSGLWTCDAGILMPYIETLVRCKRFVDIMGGYNHLRRRDQKEGYQVPAARAAVVALRAVEVFNVAASNAGEVECVICKEEMSEGRDVCEMPCQHFFHWKCILPWLSKKNTCPFCRFQLPTDDVFSEIQRLWEILVKSSELHVA
Protein: Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Q3T052)
Organism: Bos taurus (Bovine)
Function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
Subcellular location: Secreted {ECO:0000269|PubMed:15213118}.
Interaction partners:
- Beta-2-glycoprotein 1
- Haptoglobin
- Alpha-1-antiproteinase
- Apolipoprotein A-II
- Alpha-2-HS-glycoprotein
- Histidine-rich glycoprotein
- Plasminogen
- Zinc-alpha-2-glycoprotein
- Complement C1s subcomponent
Sequence:
MKTPAPGRIHSIVLVLLSLAVLQTSKAQKVQNDIDIYSLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVIDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDESRGSRVYLGPMRFGHSVGDRTSRKPGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL
Protein: Integration host factor subunit alpha (IHF-alpha) (A7MVH4)
Organism: Vibrio campbellii (strain ATCC BAA-1116)
Function: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Interaction partners:
Sequence:
MALTKAELAENLFDKLGFSKRDAKETVEVFFEEIRKALESGEQVKLSGFGNFDLRDKNERPGRNPKTGEDIPITARRVVTFRPGQKLKARVENLKADQ
Protein: Inositol phosphosphingolipid phospholipase C-Like (Q4QIE9)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Serine palmitoyltransferase 1
- serine C-palmitoyltransferase
- Phosphatidylinositol:ceramide inositolphosphotransferase
- sphinganine-1-phosphate aldolase
- Putative dihydroceramide synthase
Sequence:
MSHASTFAAGELPIRVLTFNLWGIFNSRMREARMKVFATKIEHYDVILLQEQFSVEDFDLIFQNASPVVQRTYTFRRFCSSFYGSGCAVISRYPISQAFFHTFPLQGYPEMVLHGDFFANKGAAMVRVMVPVTMADGGAAKAQEVTLYTTHLVAVYEKVSQLSSWRRERYLPFRISQAISFADFIVSTSRPTDPIIIGGDFNCSQRSLEVQMMLILLKRYGYDMHSVLPPPRALRDAAAAEQEREVGQRFFTYSDRNTFNSMKTSYFKLLKLEADIPSQIDHMFFSRPAFALLQFADCPDVADGYPCVLQDAPNGLVVFTKNEVHVPPHSAWYGSLWHQLFSGKRVPRGANATGQLAKLRCKAASSTEGQSADDAAHYYPMSDHFGVAALLGMRVEKVDSTTAMICSSAGTGGTAALALTPEEARAVQTVVAFLEDYVRKLRSQAKTARYMAVFSLLLVATNIWVLRRLSAKEEARSAAVLERIYDMAAAATRDTAMVVQPGKGLESIKHGFNTAKDWVNNQAHLTLHIVSKFTGGTPAPGINACDTPEGSKQPAANVADPSEPVPRTVPASTTATTAKRATTTPEGDAAARPDFRAIAEALTVRPLYASAWVSSAFNITAAVVGTVSFAIGVFQRAGNANVLEEQAHQLKKL
Protein: Zinc transporter YKE4 (P40544)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16760462}; Multi-pass membrane protein {ECO:0000269|PubMed:16760462}.
Interaction partners:
- Probable zinc transporter MSC2
- Zinc-regulated transporter 3
- Zinc-regulated transporter 2
- Zinc-regulated transporter 1
- Vacuolar zinc transporter COT1
- Metal homeostasis factor ATX2
- Protein ZRG17
- Vacuolar zinc transporter ZRC1
- Imidazoleglycerol-phosphate dehydratase
Sequence:
MKASHICSYLLSIAPLVVSHGVHHNRDHGHEANHESKQSFLILKQESIFYSLVCFLQNHLFVLGPRYNAIVAILIIQLMPCLFVLFVPGLRKNDRASLTLSLLVSFSLGTLLGDILLHVIPESLSGVTDVTMVGGAIFLGFISFLTLDKTMRILSGTSNDDGSIHSHSHSHTPQQTAEKKAGFNMSAYLNVISGIAHHITDGIALATSFYSSTQVGIMTSIAVTFHEIPHELGDFAILLSSGFTFPQAIRAQAVTAFGAVVGTSIGCWMNEIGNNSHKATSSSANASELMLPFTAGGLIYIATTSVVPQILHSSAPDSKLREFKKWALQLVFIFVGFAVMALMDEH
Protein: Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) (Q13882)
Organism: Homo sapiens (Human)
Function: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.
Subcellular location: Cytoplasm. Nucleus. Cell projection, ruffle. Membrane {ECO:0000250}. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Interaction partners:
- Signal-transducing adaptor protein 2
- Epidermal growth factor receptor
- KH domain-containing, RNA-binding, signal transduction-associated protein 1
- Transmembrane glycoprotein NMB
- Breast cancer anti-estrogen resistance protein 1
- Paxillin
- Suppressor of cytokine signaling 3
- Rho GTPase-activating protein 35
- Leucine-rich repeat serine/threonine-protein kinase 2
- RAC-alpha serine/threonine-protein kinase
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
Protein: Vang-like protein (Q95ZZ6)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSYQDNRKLPKDTRSCVGGFRYEGHKKQLRPRYAQSEIGEPFIPRFSAIASEGQKIAPPNEDWADNTTVLTGMTTDSFTMEEKVIYTPPIGRVIGRRFVWLLASSLLCIISVVSAPIMCSLPIIAPRFGFSMPAIQCDVDCEGLLFLMAIKTIFLVIAIGVLYWRKAMADMPRLYFVRAALTFLVMFILFAFWLFYIVRIMFERYDNYKYIVSYSTSLLDALLWTHYLSVVLLELRRLRAQFIVTIVRDPDGEMHTLNIGAGSIQEAATEILRFYTTRFSSFNIHLDNARQTAVAKQSGMQGGTAGFKMYNIEQFGGQETVSEVNTRALMEAAARRRIGGYAEVMQEELDFEKRLKKRKYRLIAAAEDAFSHVQNTAESGTNQKPGINNQMDSLTAAQNVFTWIVRPLTKYLKTTRLQSRHPSGEVTRHIERCLTLKLSHRTFLQRFFSDRIPQREIVGESKWSVICDEAVSSGVQHGTYLVLKSHNPDIDCGVQLVCTISSIPFFNLTEQAKPGNEKFSLKISNESAV