wanglab/gogpt-training-data huggingface dataset:
Protein: Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) (Q6IE81)
Organism: Homo sapiens (Human)
Function: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
Subcellular location: Nucleus {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:22654112}. Chromosome {ECO:0000269|PubMed:19187766}. Cytoplasm {ECO:0000269|PubMed:12169691, ECO:0000269|PubMed:15502158}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22654112}. Note=Localizes to the ciliary transition zone. {ECO:0000269|PubMed:22654112}.
Interaction partners:
- Histone acetyltransferase KAT7
- Inhibitor of growth protein 4
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein 5
- von Hippel-Lindau disease tumor suppressor
- Nephrocystin-4
- Histone H3.1
Sequence:
MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS
Protein: Albumin (P02770)
Organism: Rattus norvegicus (Rat)
Function: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
Subcellular location: Secreted.
Interaction partners:
- IgG receptor FcRn large subunit p51
- Alpha-2-HS-glycoprotein
- Alpha-1-acid glycoprotein
- SPARC
- Low-density lipoprotein receptor-related protein 2
- Cubilin
- Prothrombin
- Alpha-lactalbumin
- Fibrinogen alpha chain
- Alpha-1-antiproteinase
Sequence:
MKWVTFLLLLFISGSAFSRGVFRREAHKSEIAHRFKDLGEQHFKGLVLIAFSQYLQKCPYEEHIKLVQEVTDFAKTCVADENAENCDKSIHTLFGDKLCAIPKLRDNYGELADCCAKQEPERNECFLQHKDDNPNLPPFQRPEAEAMCTSFQENPTSFLGHYLHEVARRHPYFYAPELLYYAEKYNEVLTQCCTESDKAACLTPKLDAVKEKALVAAVRQRMKCSSMQRFGERAFKAWAVARMSQRFPNAEFAEITKLATDVTKINKECCHGDLLECADDRAELAKYMCENQATISSKLQACCDKPVLQKSQCLAEIEHDNIPADLPSIAADFVEDKEVCKNYAEAKDVFLGTFLYEYSRRHPDYSVSLLLRLAKKYEATLEKCCAEGDPPACYGTVLAEFQPLVEEPKNLVKTNCELYEKLGEYGFQNAVLVRYTQKAPQVSTPTLVEAARNLGRVGTKCCTLPEAQRLPCVEDYLSAILNRLCVLHEKTPVSEKVTKCCSGSLVERRPCFSALTVDETYVPKEFKAETFTFHSDICTLPDKEKQIKKQTALAELVKHKPKATEDQLKTVMGDFAQFVDKCCKAADKDNCFATEGPNLVARSKEALA
Protein: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) (Q8WR09)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}. Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
Sequence:
MRFQWFLSASASLSLFLLLDFVVWIHGERDFNVNDSQVPVIEPKDVPAYKQDPYVTELMSCQNTPSEIVLSLLLKKHDWSELTATKRAHVQAKLAKFFAIPKEFISLDSVSKRELRSMHKLAMRKGGKGNKNIETLNRRLGRANFMIGCGPSYFVMGEPIAKQIAHQMKDGTIGALTEENFGLWFIWRKELKSRSNRKRRQSEGSGADEDDYDYGDDDEEVAEPSTEVPPVTTHAHRHHHGAEGGEPDAISSGNNSLANNELSTPATPTSSVATTTASTPESSSISSNFVSTDYMEPQPEENSPPIIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKANSWLQFNADKRELYGLPLDDTVSRWQYRLSATDSGNASVTETVEISVQQHRAVRTINHEISVFVRINEKPGHNIDWQLKLINAVARTLDDSTNSAVVVREIRQTPHDPHSATFVYFNETLPTSECPEKELKDIIARLDANRLSDLVQPQLGIKSITGQLIGSCQKDLTQVKPTQHMTKNVPPMPRNQVDRVNASLGQLLVYKVPADTFYDANDNQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDIGSEEYLLVAEDSGGLSAHDALVVVVSPAPKRDFGFFFKAYLSIKHERFNADLQRKFVERVAKLNGDPTTGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSCREKEVAMTRSVYLNSDLSLREAAKRALGPELNLTNFSVVPFSICHHTENIDTNQLDYIPSRPEEPTHKSSFGEDYMITFVWPIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQDEYEEKPEIGNKSPVILKDEKPPLLPPSYNTSNMNGDNDVDDYVPPPSVVVGGREVRGKSPATPSYRKPPPYVSP
Protein: Erythroid differentiation regulator 1 (Q8VEL1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPTGRTDGRTHGRTPQGRKPAPTAPLHPPQHTGHTRAPRPPRHTRHTRHTRQAGQAHASAGPAAPATQTRTSRRGQDVHPPRSRCMCHRPSPRWTDGRTHARRQRPPVTAAAHSDVTHESTHVEADAVVKMSLPSPQDGRTDSTRCACRRGRQDGAILTEEGARQQGLTAYRNAPPQ
Protein: Mesogenin-1 (Paraxial mesoderm-specific mesogenin1) (pMesogenin1) (pMsgn1) (A6NI15)
Organism: Homo sapiens (Human)
Function: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- T-box transcription factor TBX6
Sequence:
MDNLRETFLSLEDGLGSSDSPGLLSSWDWKDRAGPFELNQASPSQSLSPAPSLESYSSSPCPAVAGLPCEHGGASSGGSEGCSVGGASGLVEVDYNMLAFQPTHLQGGGGPKAQKGTKVRMSVQRRRKASEREKLRMRTLADALHTLRNYLPPVYSQRGQPLTKIQTLKYTIKYIGELTDLLNRGREPRAQSA
Protein: Trafficking protein particle complex subunit 2 (E5RFG0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
Sequence:
MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSA
Protein: DnaJ heat shock protein family (Hsp40) member A3 (A0A0G2K4Y1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAARCSPRWFRVAVGTPRLPAAAGRGVQQPQGGVVAASLCRKLCVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTASFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCSGSGMETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTVPVPAGVEDGQTVRMPVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKGIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGKRSTGN
Protein: Uncharacterized oxidoreductase C922.06 (EC 1.-.-.-) (Q9URX0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MTVEGRVVLITGAAGGIGKVLCKMFTELGDRVAGIDIVDPSKVQDAALALQADVSKADQIETAIEKVIQTLGPIDVLINNAGLADDTPFEQLSHESWDHDVSLVLRGNYLTQRYVIPHMAKQGKGGSIVNIGSVNGHIYLGSPAYSAAKAGLENLTKALAVRYGPLGIRVNVCAPGTIWSPAWDERFKKHPDVGDRMKRWYPVGRLGTPEDVARAVIFLADSKNSFITGTTLYVDGGLLAGNPCLIQDIYSENNNFVF
Protein: Protein FAM170A (Zinc finger domain-containing protein) (Zinc finger protein ZNFD) (Q66LM6)
Organism: Mus musculus (Mouse)
Function: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).
Subcellular location: Nucleus {ECO:0000269|PubMed:22231842}.
Interaction partners:
Sequence:
MKRRQKRKHLEIEESKEAGISKSQEDISHPESTGVPKAQSPGVGEVSSASEYFSCVSSPQKLIHRSKGTWKLLQDSSKPRSPLDQVPEGEATTAPSQQASSSCPSYKTCVSSLCMNKEERGMKIYYMQVQMKKGVAISWDTKETSESLEKQPRMEEATLPEGVWVGTPPSDVSTRNLLSDSEPIGEEKEHEEKPESDSPPGSPAVEERPRAKTPDWLVTMENGFRCMACCRVFATMESLQEHVQYGIREGFSCHVFHLTMAQLIGSMESESTQEEEEDHTEETEKPKEEKAEEQQPTEEDVGMKKPWSQCPGCVFDSPKDRRRRKDHCDNSGS
Protein: Na/Ca-exchange protein, isoform G (A0A0B4K6E2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Transient-receptor-potential-like protein
- Neither inactivation nor afterpotential protein C
- KCNQ potassium channel, isoform F
Sequence:
MQLLLKSIFTCALFVIFVYATAQSLLKVQETEARQAYLNVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAPDAEELRECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIRV
Protein: Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Q8BVI4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Interaction partners:
- Sepiapterin reductase
- Pterin-4-alpha-carbinolamine dehydratase
- Phenylalanine-4-hydroxylase
- Dihydrofolate reductase
- Pterin-4-alpha-carbinolamine dehydratase 2
- Tyrosine 3-monooxygenase
- Tryptophan 5-hydroxylase 1
- Tryptophan 5-hydroxylase 2
- Aldo-keto reductase family 1 member B1
- Aldose reductase-related protein 2
Sequence:
MAASGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVVVKMTDSFTEQADQVTADVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCDMMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGNKRPNSGSLIQVVTTDGKTELTPAYF
Protein: Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (G5EDM4)
Organism: Caenorhabditis elegans
Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility.
Subcellular location: Cell projection, microvillus membrane {ECO:0000269|PubMed:22916205}. Apical cell membrane {ECO:0000269|PubMed:22916205}. Note=Co-localizes with aat-6 at the apical cell membrane of intestinal cells. {ECO:0000269|PubMed:22916205}.
Interaction partners:
- Amino acid transporter protein 6
- Golgi-associated PDZ and coiled-coil motif-containing protein
- Moesin/ezrin/radixin homolog 1
- Large neutral amino acids transporter small subunit 1
- alpha-glucosidase
- Large neutral amino acids transporter small subunit 1
- FERM domain-containing protein
- Amino Acid Transporter
- Amino acid transporter
- Sodium/hydrogen exchanger
Sequence:
MVHIPSDVTPPRLCVVEKLNGENEYGYNLHAEKGRGQFVGTVDPDSPAERGGLITGDRIFAVNGHSIIGENHKKVVERIKANPNRCEMLVISEEGAKWYNENNVQITLDLPNIERVSPMSKETPVFVPPPPPPTDAMPYLPRLAELNKGTPDQEFGFNLHAERGRGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSNGYDVPPLNPHSIQVNEEREISKMTTTTRTETITNSNSAYQYKESSTAYDAYATPPVDSNDLMDEVFGRVNLPGVTMSSHTEVLPPTDDISSVSSLSSHRESAVDVPVSHQYVPSYATESHQKHEQHSQTHHHHHQHQQPSPLSNGSSHGYAASSTSGYDDDDIYHLSAREARERLRMKNRKHHLHEMSLNEKYQLVSNM
Protein: Single-strand-selective monofunctional uracil-DNA glycosylase 1 (D6RAS0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTG
Protein: Hexosyltransferase (EC 2.4.1.-) (Q8C228)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU364016}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU364016}.
Interaction partners:
Sequence:
MRLSSLLALLRPVLPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGKPGGPQNPDSKNGLDQGDEDFRPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARAPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGHAEEFIGTGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDTLGIGCVSQHQGQQYRSFELAKNRDPEKEESPAFLSAFAVHPVPEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPYPASHGSV
Protein: Homeobox protein TGIF1 (TGFB-induced factor) (Q803F0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog.
- Homeobox protein TGIF2
- ZIC family member 2 B
- Six3
- ZIC family member 2, A
- Sine oculis homeobox homolog 3a.
Sequence:
MKTKKGVLAMSGSETEDEDSLDVPLDLSSNGGVSGKRKRRGNLPKESVQILRDWLYQHRYNAYPSEQEKALLSKQTHLSTLQVCNWFINARRRLLPEMLRKDGKDPNQFTISRRGSKGGEMLSDNSQSPKHGLLANGEDRNSYEPGSPHPTSNTPTSNGYPKKALSPKTPPSPGPVLPRPSVICHTTITTATQGINTTTRLGVEGATELPLTDAASLFGCRGEGNVSPQSGLFNTPPPTPPDLTQDFSGFQLLVDVALKRAAEMELQAKKLLA
Protein: Diencephalon/mesencephalon homeobox protein 1-B (Q566X8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8NFW5, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
- Aminoadipate aminotransferase.
Sequence:
MQHYGVNGYSLHAMNSLSAMYNLHQQAAQHAQHAPDYRPSVHALTLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQRLKEAGTEGAQDEGKEEAPPVEAQAPPSPLDGRGLTSAPSCELNEEVNVTSPEQSGAESGAEDTTDREDEPLSIKDEIKEAGPPLMTDDSSPSYKPLSPKSDDPLVSPALPSSSGAVAQSNSYASSPLSLFRLQEQFRQHMAATNNLMHYPAFDVTAPSSLPYLGVNVNMASPLGSLPCQPYYQTLTQAQQMWSSPLLQGSGGLPALNSKTTSIENLRLRAKQHAASLGLDTLPN
Protein: Large ribosomal subunit protein eL31B (60S ribosomal protein L31-B) (L34) (YL28) (P0C2H9)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL21A
- Large ribosomal subunit protein eL30
Sequence:
MAGLKDVVTREYTINLHKRLHGVSFKKRAPRAVKEIKKFAKLHMGTEDVRLAPELNQAIWKRGVKGVEYRLRLRISRKRNEEEDAKNPLFSYVEPVLVASAKGLQTVVVEEDA
Protein: Probable gliding protein mglA (Q5SJ82)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Interaction partners:
Sequence:
MSTINFANREINFKIVYYGPGLSGKTTNLKWIYSKVPEGRKGEMVSLATEDERTLFFDFLPLDIGEVKGFKTRFHLYTVPGQVFYNASRKLILRGVDGIVFVADSAPNRLRANAESMRNMRENLAEYGLTLDDVPIVIQVNKRDLPDALPVEMVRAVVDPEGKFPVLEAVATEGKGVFETLKEVSRLVLARVAGGS
Protein: Phosphomannomutase (DoPMM) (EC 5.4.2.8) (A0A0U1WZ18)
Organism: Dendrobium officinale (Orchid)
Function: Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose (Probable). GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate (Probable). Involved in the biosynthesis of ascorbate and polysaccharides in response to abiotic stress during seed germination.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27987037}.
Interaction partners:
Sequence:
MTGRMPGLIVLFDVDGTLTAPRKAITPKMLEFMQDLRKVVTVGVVGGSDLVKISEQLGKSVISDYDYVFAENGLVAYKNGELIGKQNFKSFLGEEKLKELINFTLHYIADLDIPIKRGTFIEFRSGMLNVSPIGRNCSQEERDEFEKYDKVHNIRSKMVSVLREKFKHLNLTFSIGGQISFDVFPQGWDKTYCLRYLEDFPEIHFFGDKTYKGGNDYEIYESERTVGHTVTSPDDTAEQCKLHFLAKQAGDA
Protein: DNA polymerase (EC 2.7.7.7) (F4HTM5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU000442}.
Interaction partners:
Sequence:
MADSQSGSNVFSLRIVSIDYYMASPIPGYNICYSSFQGSEVNEVPVIRIYGSTPAGQKTCLHIHRALPYLYIPCSEIPLEHHKGVDGSTLALSLELEKALKLKGNAASKRQHIHDCEIVRAKKFYGYHSTEEAFVKIYLYHPPDVARAASLLLAGAVLGKSLQPYESHIPFILQFLVDYNLYGMGHVHISKMKFRSPVPHHFRPRRFDLDDCPGQRIDEVAITKANSSAAASVSFPVWSLSTIPGQWMWNLSEESDTPLSQSQHRHQHHYRRQSLCELEGDATSSGNFPDSKFNCLCFMYDRTFELASSLVDILNQQFKMYNSLSQAQSDTNMVQSLVAIWEEEYERTGVHDAPIPPDPGKPSAADVLQTMSDYVGFGNMLKEMLNKVELSPPGMKPTAVSSAGPDMHAKPEITDLQALNHMVGTCSEFPASEQLSPLGEKSEEASMENDEYMKTPTDRDTPAQIQDAEALGLFKWFASSQAAEDINSDDEILRETILSPLLPLASINKVLEMASTDYVSQSQKECQDILDSQENLPDFGSSTKRALPSNPDSQNLRTSSDKQSLEIEVASDVPDSSTSNGASENSFRRYRKSDLHTSEVMEYKNRSFSKSNKPSNSVWGPLPFTLTKNLQKDFDSTNASDKLGLTKISSYPMNEMTDNYIVPVKEHQADVCNTIDRNVLAGCSLRDLMRKKRLCHGESPVSQHMKSRKVRDSRHGEKNECTLRCEAKKQGPALSAEFSEFVCGDTPNLSPIDSGNCECNISTESSELHSVDRCSAKETASQNSDEVLRNLSSTTVPFGKDPQTVESGTLVSSNIHVGIEIDSVQKSGREQESTANETDETGRLICLTLSKKPPSLDCLSAGLQDSAHSHEIHAREKQHDEYEGNSNDIPFFPLEDNKEEKKHFFQGTSLGIPLHHLNDGSNLYLLTPAFSPPSVDSVLQWISNDKGDSNIDSEKQPLRDNHNDRGASFTDLASASNVVSVSEHVEQHNNLFVNSESNAYTESEIDLKPKGTFLNLNLQASVSQELSQISGPDGKSGPTPLSQMGFRDPASMGAGQQLTILSIEVHAESRGDLRPDPRFDSVNVIALVVQNDDSFVAEVFVLLFSPDSIDQRNVDGLSGCKLSVFLEERQLFRYFIETLCKWDPDVLLGWDIQGGSIGFLAERAAQLGIRFLNNISRTPSPTTTNNSDNKRKLGNNLLPDPLVANPAQVEEVVIEDEWGRTHASGVHVGGRIVLNAWRLIRGEVKLNMYTIEAVSEAVLRQKVPSIPYKVLTEWFSSGPAGARYRCIEYVIRRANLNLEIMSQLDMINRTSELARVFGIDFFSVLSRGSQYRVESMLLRLAHTQNYLAISPGNQQVASQPAMECVPLVMEPESAFYDDPVIVLDFQSLYPSMIIAYNLCFSTCLGKLAHLKMNTLGVSSYSLDLDVLQDLNQILQTPNSVMYVPPEVRRGILPRLLEEILSTRIMVKKAMKKLTPSEAVLHRIFNARQLALKLIANVTYGYTAAGFSGRMPCAELADSIVQCGRSTLEKAISFVNANDNWNARVVYGDTDSMFVLLKGRTVKEAFVVGQEIASAITEMNPHPVTLKMEKVYHPCFLLTKKRYVGYSYESPNQREPIFDAKGIETVRRDTCEAVAKTMEQSLRLFFEQKNISKVKSYLYRQWKRILSGRVSLQDFIFAKEVRLGTYSTRDSSLLPPAAIVATKSMKADPRTEPRYAERVPYVVIHGEPGARLVDMVVDPLVLLDVDTPYRLNDLYYINKQIIPALQRVFGLVGADLNQWFLEMPRLTRSSLGQRPLNSKNSHKTRIDYFYLSKHCILCGEVVQESAQLCNRCLQNKSAAAATIVWKTSKLEREMQHLATICRHCGGGDWVVQSGVKCNSLACSVFYERRKVQKELRGLSSIATESELYPKCMAEWF
Protein: EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) (Q9H223)
Organism: Homo sapiens (Human)
Function: ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:18331452}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:18331452}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9EQP2}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9EQP2}.
Interaction partners:
- Rabenosyn-5
- MICAL-like protein 1
- EH domain-containing protein 1
Sequence:
MFSWMGRQAGGRERAGGADAVQTVTGGLRSLYLRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEETSTPTQLVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRKSLPKAD
Protein: Emb|CAB71880.1 (Endonuclease or glycosyl hydrolase) (Q9FIC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKFGSLPSKSLLFRLSSSSTTQSHRRTITLFITNIHSSPFSTTTTSGSNFVSGSSHSPSRRPQQDEESRSVRVSVWWDFLSCNLPVDTNVYKVAQSITAAIRNSGIKGPITITAFGDVLQLPRSNQDALSATGISLTHVPNGGKNSADRSLITDLMCWVSQNPPPAHLLLISSDKEFASVLHRLRMNNYNILLASKSSAPGVLCSAASIMWDWDALIKGECVTGKHFNQPPDGPYNSWYGHYRIPLLDPFAIATTTEQSSSSVKIEELSESVNSNAVVNLRPIPKEVVDKIRSIVSLYPKGAAITELRAELSKSNLAIDKDFYGHKKFSKFLLSMPDILQVTTVSEGLFMIRAVTEKKPPMRLDSSPRLSTAVDQKIKDKETVNAPSPKLISDVELAAERRRDGLLGKKQEKVLESDKIVKEESSESSQDPILVGQKDVKANVKPVETNQVALVAWSDSSMEDGFFQKLKRLWYGSPEMELEHLPEMKSVSGSGDTHREDNDLKSSSQGSGNKHKEDKDLKSSSQGTVPMSQISPSFVAESVDEVKVGADDVDSKDKDASPGFLGRLLKSFKFWGKNTKSSKDSSGNQELVNVDSQVQDIFAKEYFWSDIESFINSPRGFAIVSHSRTREVMAKNVQEEGPSCLRLLDESSMLHLVTLLISEKKWIEETPSSSLPFRIIKGSSPGHRHASNGLSSIFSDSSKSQWQKQNGEKSGKNVAHAGVSVGSVDRKELERYKSNAIADCQKMIKKITEEHPEGYSLIRFRKDFLEEYGYHLAVDKLGYDNLQSLIRVMHGVRIASGYIFPSTPSPNAKSKEDDSDLAFAELGPVSDTTTTHPTTKKLPVYEPSLSEDEEDSGSERDNPEKKKQQMMSKEGKESSLLQILDSYYTNKDGELKENPVERKLVSNGRKQKPTKTYSFVKDSEV
Protein: Trans-2,3-enoyl-CoA reductase-like (EC 1.3.1.-) (Steroid 5-alpha-reductase 2-like 2 protein) (Q5HYJ1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:27861123}.
Interaction partners:
- Polyprenal reductase
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- Very-long-chain
- Very-long-chain
- Very-long-chain
- Very-long-chain
- Proton-activated chloride channel
Sequence:
MFKRHKSLASERKRALLSQRATRFILKDDMRNFHFLSKLVLSAGPLRPTPAVKHSKTTHFEIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAASSIVTLYATDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPCIYDGKESARRLRHPVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWGFTSWIAYYINHPLYTPPSFGNRQITVSAINFLICEAGNHFINVMLSHPNHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTLLMSIQMSLWAQKKHKIYLRKFNSYIHRKSAMIPFIL