wanglab/gogpt-training-data huggingface dataset:
Protein: DNA repair protein REV1 (AtREV1) (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (A3EWL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Deoxycytidyl transferase involved in DNA repair and translesion synthesis (TLS). Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. Mediates also the insertion of dTMP or dGMP when the opposite base is G, and, with a low efficiency, dGMP insertions opposite G, T, and C, dAMP insertions opposite G, A, and T, and dTMP insertion opposite A. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (e.g. UV and gamma ray), mostly via G to T transversions, and of spontaneous mutations in somatic cells. Confers resistance to ultraviolet-B (UV-B) and various DNA cross-linkers (e.g. mitomycin C MMC and cisplatin). Promotes stem growth.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA polymerase zeta processivity subunit
- DNA polymerase zeta catalytic subunit
- DNA polymerase eta
- Proliferating cell nuclear antigen 2
- Proliferating cellular nuclear antigen 1
- DNA polymerase kappa
- Myosin heavy chain-like protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- Ubiquitin-ribosomal protein eL40z fusion protein
- Replication factor C subunit 5
Sequence:
MKRSLGSNSSNNSGSGSNKKSKKNNNPSNQKTLGAAWGAASSRSSFRSSPFSDFGSYMEVKNRKLQNQFETEASAASRGVSGSEKLIFQGVSIFVDGFTIPSHQELKGYMMKYGGRFENYFSRRSVTHIICSNLPDSKVKNLRTFSRGLPVVKPTWIVDSISANRLLGWVPYQLDQLNDTQPKLSAFFAPRSHLTPQMASPVTSFQPDTGYSEAEEGSSIRADDSEEARDHIDDEIDGVYIENTTPELTEQTGTGDLKSSEMNAEGLGNYDIEEKEVSSELQSTTNLHSTSDNKSVHANGKNGGKSIATAAGSSTRRHSTLEDPNFVENYFKNSRLHFIGTWRNRYRKRFHGSSNGLKWADSGQNTAEMAKKSTIIHIDLDCFFVSVVIKNRLELHDKPVAVCHSDNPKGTAEISSANYPARAYGVKAGMFVRHAKDLCPQLVIVPYNFEAYEEVADQFYDILHRHCRKVQALSCDEAFLDVSDLSDVETEVLASTIRNEILETTGCSASAGIGGTMLMARLATRVAKPAGQLYISAEKVEEFLDQLPVGTLPGVGSVLKEKLVKQNIQTCGQLRLISKDSLQKDFGVKTGEMLWSYSRGLDLRSVTAVQESKSIGAEVNWGVRFRDQQDVFILVQHFLQCLCKEVSLRLQGCEMIGRTFTLKIKKRKKDAEEPTKYMGCGDCDNLSRSITVPAATDDIEVLQRISKKLFGSFCLDVKEVRGVGLQVSKLDSADPSNKGSRTLKSWLSSAPAVVQIEQDDNVFAAKVRENSDCNRPVTGGVSRLRESNSEESSIQSGDTNSSLPPMCYLDMEVLENLPPELLSELDGTYGGKLFELIEKKRGKRRINCNSPHVSLDGTAASIKELKSLSVKIHGLSTSGEKEYKEPYVPHPSIARTSNQHTIEMTDLLPSSLSQVDVSVLQELPEELRADVLGAFPSHRRQQSSSDVPKETCKKQDEEPIDLKGTENEIGLSFSSLWFGNPPLWTEKFKVSGNCTMEKLSAIYFKVAQSRPMLSLVLQHAISEMSSFPDAASASDLDKAIYDVCELLKQYINLKVGGDIEEIYLCFRLLKRLAARSQLFLQVYEILSPFIQASISEHYGGSLSIP
Protein: Inositol diphosphatase DSP5 (EC 3.6.1.52) (Inositol pyrophosphate phosphatase DSP5) (Protein PLANT AND FUNGI ATYPICAL DUAL-SPECIFICITY PHOSPHATASE 5) (AtPFA-DSP5) (Q9FFD7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses low phosphotyrosine phosphatase activity in vitro. Hydrolyzes O-methylfluorescein phosphate in vitro. Dephosphorylates the phosphoinositides PI(3,5)P2.
Interaction partners:
- Photosystem I reaction center subunit III, chloroplastic
- Photosystem I reaction center subunit VIII
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- acid phosphatase
- Photosystem I reaction center subunit IX
- Photosystem I subunit O
- Photosystem I chlorophyll a/b-binding protein 5, chloroplastic
- At3g27200
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
Sequence:
MGLIVDDDNDGEVLIPPPNFSMVEDEIYRSGFPELENFGFLSTLNLRSIIYLCPEPYPEDNLKSLASNNIKLFQFGIEGKTDPPTPMPKDTVLSALRVLVDVRNHPILIHCKRGKHRTGCLVGCLRKVQNWCLSSVLEEYQKCAGLKWRQRDLRFIEDFDVLRLKQCLYSIIYQYNGYGLKRRKLLYQEENVVQEQQKPQATKG
Protein: Leucine-rich repeat protein (Q580Z9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDAEENFLNAIQQAFDENATTLHFSYQEGTTAVPPEIRALRGTLEILHIDNNYSLGSLPSAIGELGRLRWLNASYCRLTTVPREMGRLSHLERLHLGNNLLQELPMEMWQLKSLQELRVENNQLRVLPGGLLFLPRLEVLLLENNPLLLPEEVNGAAPITIAPRLYSVDCSNCCVRMRDHEVLVTVNNKSGHRDIPFVHCVCSDACKQHLQTRLQGYDAANSA
Protein: O-fucosyltransferase family protein (F4HTC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVKVSSSTTSSSSSSSPDEESDLQNLLEESDSQIDQFRISDEAAEQRPTFDVESLRSRLRRSFKLNLTKKQSIFIFLPIVIILIYLSTDFSNYFSVKVPNSAFRSNTLTGRVHESDLQALYLLRKQESDLFSIWNHTVSNLSTIDDVKSAVFRQISLNRQIQNALLSPHKTGNVDIGGSSDGYFAGGSCRKVDQKLNGRKTIQWKPRPDKFLFAICLSGQMSNHLICLEKHMFFAALLKRVLVIPSHRFDYHYSRIIDIDRINTCLGRTVVVSFEEFWKKDKNRKKHHHVHINRFICYFSKPEPCYVDKEHITKLKALGITVGGKLDTPWEEDIARPSNKTAEEVEANFRSDDDVIAIGDVFYANVEREWVMQPGGPVAHKCRTLIEPNRLILLTAQRFIQTFLGKNYIALHFRRHGFLKFWYDLFSTSLLHSTFDDNVVHFITKIKSGTLAKKFSWCASNAKNPSCFFPIPQAASCITRLIEKVEAPVLYLSTDAAESETGLLQSLLILNGKTVPLVKRPARDSAEKWDALLYRHGLEGDSQVEAMLDKTICALSSVFIGASGSTFTEDILRLRKDWGTASECDEYLCANEQPNFIADHE
Protein: Neuronal acetylcholine receptor subunit alpha-5 (Q2MKA5)
Organism: Mus musculus (Mouse)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:P32297}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P32297}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuronal acetylcholine receptor subunit alpha-4
- Neuronal acetylcholine receptor subunit alpha-3
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-9
- Acetylcholine receptor subunit gamma
- Acetylcholine receptor subunit beta
- Neuronal acetylcholine receptor subunit alpha-6
- Acetylcholine receptor subunit delta
- Neuronal acetylcholine receptor subunit alpha-2
Sequence:
MAARGSRRRALRLLLMVQLLAGRWRPAGAARGARGGLPELSSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPCITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFTQREEAEKDGGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK
Protein: Phosphatidylinositol N-acetylglucosaminyltransferase subunit gpi15 (EC 2.4.1.198) (PIGH homolog) (Q9Y7L7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
- Meiotically up-regulated gene 84 protein
- Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1
- GPI mannosyltransferase 2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Putative holo-[acyl-carrier-protein] synthase
- Uncharacterized deaminase C1683.02
Sequence:
MLTIKRYPGAIEFTVHTSKSYGTQMFALCFISFVIGATSLAIGRSPKIIITLVELSFLLSLFHIISGVNHESLFVIRDLGVQTNCHSIVPWKSSSKLIPLDSIRDIFINEGFRKFDVCYYMGIAIESETEIHVVFPTLLPRHDVLQKVYKETVILLANNS
Protein: Sinapine esterase (BnSCE3) (EC 3.1.1.49) (Lipase 2) (BnLIP2) (Q3ZFI4)
Organism: Brassica napus (Rape)
Function: Sinapine esterase that catalyzes that hydrolysis of sinapine, releasing choline and sinapate. Sinapine (O-sinapoylcholine) is the predominant phenolic compound in a complex group of sinapate esters in seeds of oilseed rape (B.napus). Sinapine has antinutritive activity and prevents the use of seed protein for food and feed. Shows broad substrate specificity towards various other choline esters, including phosphatidylcholine.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MASSLKKLITSFLLFFFYTIIVASSEPSCRRYKSIISFGDSIADTGNYLHLSDVNHPPQAAFLPYGETFFSVPTGRDSDGRLIIDFIAEFLGLPYVPPYFGSQNVSFEQGVNFAVYGATALDRAFFIEKGIVSDFTNVSLSVQLNTFKQILPTLCASSSRDCREMLGDSLILMGESGGNDYNYPFFEDKSINEIKELTPLIIKAISDAIVDLIDLGGKTFLVPGSFPVGCSAAYLTLFQTAKEKDYDPLTGCLPWLNDFGKHHDEQLKTEIRRLRKLYPHVNIMYADYYNSLYRLYQKPTKYGFKNRPLAACCGVGGQYNFTIGEECGYEGVGYCQNPSEYINWDGYHITEAAHQKMAHGILNGPYATPAFNWSCLDAASVDNESSFGS
Protein: Serine/threonine-protein kinase WNK (EC 2.7.11.1) (Protein kinase with no lysine 1) (X5M5N0)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H4A3}. Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress. {ECO:0000250|UniProtKB:Q9H4A3}.
Interaction partners:
- Solute carrier family 12 member 1
- Germinal center kinase 3
- K+/Cl-Cotransporter
- Skp1-related protein
- Transcription factor jun-1
- Chloride channel protein clh-3
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
Sequence:
MPDSITNGGRPPAPPSSVSSTTASTTGNFGTRRRLVNRIKKVDELHPAQENPTMGSHWLSEQERSRLEAVQQDWRRTRPMKFQWTSKKRPDDPTTSSPSTVSISNALENSTPSLNNVSSITNSSSPFSLSSAATSTASAIIPFTSNVATNHPHLNHHVSRIPQAIVTGGTNGSLPPLLISPTSAAAATPLISGKAGPMSPSTGSPINVAATVLQNAVSSPQHSIFDRSRLNKIPPNTSLASSSSPSDAANNDKPIQQRHSILSNVRTLTQAMVNDGPRTLTGDDMDKMVSEEERARKEQEKREEEEKAARRIDVEDDFDAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFKRINIKVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLNDLNVEIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDEDTRMITKLIKDKVDAFRRDRDHRLLEIKRAKEEEERIREEAEIKEELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNPTPIPPTPATPHSSAQQQPIPPPLSTQTSAEIQQSAQQPSVPVTMIANIPAMSPTSAQPQPVLSPTSAAVPVPTTMIHVPKPSEIPVQNVATTAAPVAANNVPPSPAPFKTEDIQTPTLAQNTVPRTISTDASGLVINTPASIASPSPAPSATDVASTTAPVTPAPTPTTTTDGGAAAASTTTENKEEKRKSNKRKVVMEILGCDESRNFALVSCRLDTSHKSVTFQFAPGTDKPCTIATKLLAEDCLLKVHVHIVEAQLGEVIQLINSDGKKGVGTKLATVLDPNSTEPPTITAVMPKDSSAATASNTKPKIEIEKTPPTRDASQEPNNVQVTNVRKVSQESNAESVQSIPRPGGIIVMSPTNQTDSAPPPTGAAAKPSRFQVTKSADPIATPISSSISTATVIPIVAATPTNITSEPVIVQPITAQVITHLATPSPVSHSLSSNSSPSATTHSNMSSIQSTTSVPGRRFTVQPVSQAESGISSSISTPHPEPTPAITSCPPPVPSVPPVVSNGTLNLEVAPKQTPSATNQNVDTQHSSSTASTATLVSETPATVHVTPISVPAPVQEPLVIDHHSDVLTQLDSELRKCFQVSGVSHSASPSTVVESLTSMTPQTIPLACQTVPASIGQAPAVIAAAHAASLIPNASVPQSPSRLDAETGLAGLHEKLEALKMEQDRREDMGDDAIGTTTTDGKDEIPIDTLKGLAEALGKVIHADGRETTPMPPDHPDLTDASTQQLISPSNPDVLTTMSSAVEGSASSTMIEDIDASTSAVDASMMNSMPPGAQNSTDQIPAAMTLSMDQECAQSMTSSITRNTTGTKLATFENLETALSSTLGTHIRQPNAPSSRDETTAPMTPSFTNERIGGGGGGGATSFSIGTPPSHSPFPVSECDYDLKGQMDLESEDPEVIQMIVRHRMEQHKLLEKQRVEIERLRSKIRVPRATSVNPEMIGDDEADTTLTALQSALGNASLSLPASPPPNTEIPDNEGQHHCNSFRCIGDPNDNVSIVNQIKQRLGIIPSSRQSVRSATSSSPSTPPSSSSAPPKSLSSPTKSYVSHCSLSIGYGSTASSEQQQREPSPSATTSSFLSDPATGVIENV
Protein: GAS (Human Growth Arrest-Specific) Related (Q18689)
Organism: Caenorhabditis elegans
Interaction partners:
- Cilia- and flagella-associated protein 157
- Fas-binding factor 1 C-terminal domain-containing protein
- TALPid3
- SET domain-containing protein
- Girdin homolog
- ADP-ribosylation factor-like protein 13B
Sequence:
MKTAGTSRDTSSNIQNKRVMKKPKAIRSTLSTNAASRRKPAIGSAAKKKVQVVEPIQNQNADSRKIAEVEKKLNAIQITKDRLKDRADKLSGELTKTRVELNAAQQERGRIQQFWRIAENGLGEERERTRDVEKSMFDMKTHQATHIQKLQQRIRSLVFHAKMHRNAGTQSEAIAPSGGLESVECQTMEELTKEKAANILRQSDDLLVTFIAELEKEKLEAQSDLKYAIVHLEQRMKEEQETQMQAMKEEREIEIEEIGLKHMEQIRTIESGNSEQTAMMQGKIDFLQSEVSNLRDLRDSISADLIDSREKLKDQAVLLGQNQANIDEMSKEIARLQDYKRNFQRDMRNVENMRKEVEKYKELNDIVMGEFEKLEKERDQLLIEVERNVGRLEISNQQKFEKLEERGRRF
Protein: Kininogen 2 (Kng2 protein) (LMW kininogen-II) (Q6S9I0)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
Sequence:
MKLITTLLLCSGLLLTLTQGEEAQEIDCNDEAVFQAVDASLKKLNARLQSGNQFVLYRVTKRAKMDGSATFYSFNYQIKEGNCSAQRGLAWQDCDFKDSEEAATGECTATMGKKENKFFIVTQTCKITPGKGPIVTEEYHCASCVHPISADNPDLEPVLKHAIEYFNNNTGHSHLFALREVKSAQGQVVGGLNFDIIYTIVQTNCSKERFPSLRGDCVALPNGDGGECRGNAFLDTDNKIEDFTQSCDLHPGDDLVEALPKPCPGCPRDIPVDSPELKEVLGHSIAQLNTENDHPFYFKIDTVKKATSQVVAGTNYVIEFIARETKCSKESNTELTEDCEIKHLGQSLDCNANVYMRPWENKVIPTVKCQALDKTIPIRRRPPGFSPFRSAKVQETKAGTTRLLRACEYKGRLSKAGAEPAPERQAESSQVKQ
Protein: Kinesin light chain 1 (KLC 1) (P37285)
Organism: Rattus norvegicus (Rat)
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Subcellular location: Cell projection, growth cone {ECO:0000269|PubMed:14970196}. Cytoplasmic vesicle {ECO:0000269|PubMed:14970196}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14970196}.
Interaction partners:
- Kinesin-1 heavy chain
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- C-Jun-amino-terminal kinase-interacting protein 1
- Kinesin light chain
- Kinesin light chain 4
- Kinesin light chain 3
- C-Jun-amino-terminal kinase-interacting protein 3
- Calsyntenin-1
- Alpha-synuclein
Sequence:
MHDNMSTMVYMKEEKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDSDSSKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAEVLNDPENVEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGMRKMKLGLVK
Protein: Caveolin (Q6YLH7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|RuleBase:RU000680}. Membrane, caveola {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|RuleBase:RU000680}.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase Src
- Tyrosine-protein kinase fyna
- Caveolin
- Dysferlin
- Tyrosine-protein kinase fynb
- Caveolae-associated protein 1b
- Caveolae-associated protein 1
- Actin alpha 1, skeletal muscle b.
- Popeye domain-containing protein 1
- Early endosome antigen 1
Sequence:
MADQYNTNEEKILRDSHTKEIDLINRDPKQINEDVVKVDFEDVIAEPDGTHSMDGVWKASYTTFTVSKYWCYRVLSAVFGIPVALLWGFCFACISFCHIWAVMPCIKSYLIETQCLSRIYSLCIHTFCDPLFEALGKIFSSVRVALRKEV
Protein: S-adenosylmethionine synthase (EC 2.5.1.6) (Q586F9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- Homocysteine S-methyltransferase, putative
- DNA
- S-adenosylmethionine decarboxylase proenzyme-like, putative
- S-adenosylmethionine decarboxylase proenzyme
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
- NAD
Sequence:
MSVRQIFFTSEHVSEGHPDKLCDQVSDAVLDACLEQDPLSKVACETCSKTGMVLVFGEITTKAVIDYQKVVRDTVKEIGFDNTEKGLDYRSLNLLVAVEQQSPDIYQGLGDFGGENLGAGDQGMMFGYATNETETLMPLSYELARGLAMTYSELRRNGGLPWARPDAKTQVTVQYEYDTRGGKQLLTPKRVAVILVSAQLDDGVSNETIREDLVKKVISTTIPAKFLDENTKYHLNPSGRFVIGGPHGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSLVAAGLADRCLVQLSYAIGVAEPLNIHVDTYGTGKRDDEYILGIVQKNFRLRPYDIIKELDLRRPIYRQTACFGHFGRVDTNGKGGFTWEVPKTLEGLSDVQ
Protein: Desiccate (RE68889p) (Q9VGX0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD25952p
- Lipase
Sequence:
MNRNYIVILQLLGVLVVLTYASAIPKYEDSHKFYADKAQRDRSYFNENKTQPSEPQTASTKDRLERLGYTTGYGSLNGYPGGTGLSAYNPIKLDLGGVVLGTLVGIGAIILIPKILSAFHGGYGGYGRSEDSDLTPLSSMINKIDDVLGQNNIDSTSCMQRAVCGYVRSTEYNMKIGSSDQMDEFIHMLAENALVDYLLDGTAIKEALEHGKRANDRACEEVYSNCPLDSKSATDILMKLMPKKNPQGKGKSSGISREKKV
Protein: Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) (Q12429)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Diphthine methyl ester synthase
- Elongation factor 2
- Diphthine methyltransferase
- 2-
- 2-
- Diphthamide biosynthesis protein 4
- Diphthamide biosynthesis protein 3
- Protein HMF1
Sequence:
MKFIALISGGKDSFYNIFHCLKNNHELIALGNIYPKESEEQELDSFMFQTVGHDLIDYYSKCIGVPLFRRSILRNTSNNVELNYTATQDDEIEELFELLRTVKDKIPDLEAVSVGAILSSYQRTRVENVCSRLGLVVLSYLWQRDQAELMGEMCLMSKDVNNVENDTNSGNKFDARIIKVAAIGLNEKHLGMSLPMMQPVLQKLNQLYQVHICGEGGEFETMVLDAPFFQHGYLELIDIVKCSDGEVHNARLKVKFQPRNLSKSFLLNQLDQLPVPSIFGNNWQDLTQNLPKQQAKTGEQRFENHMSNALPQTTINKTNDKLYISNLQSRKSETVEKQSEDIFTELADILHSNQIPRNHILSASLLIRDMSNFGKINKIYNEFLDLSKYGPLPPSRACVGSKCLPEDCHVQLSVVVDVKNTGKEKINKNKGGLHVQGRSYWAPCNIGPYSQSTWLNDDANQVSFISGQIGLVPQSMEILGTPLTDQIVLALQHFDTLCETIGAQEKLLMTCYISDESVLDSVIKTWAFYCSNMNHRSDLWMDKSDDVEKCLVLVKISELPRGAVAEFGGVTCKRLIVDDNDSDKKEREENDDVSTVFQKLNLNIEGFHNTTVSAFGYNRNFITGFVDSREELELILEKTPKSAQITLYYNPKEIITFHHHIGYYPVEKLFDYRGKEHRFGLHIRS
Protein: TATA-box-binding protein (TATA sequence-binding protein) (TBP) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) (P26355)
Organism: Dictyostelium discoideum (Social amoeba)
Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular location: Nucleus.
Interaction partners:
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor IIB
- Transcription initiation factor TFIID component TAF4 C-terminal domain-containing protein
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 9
- TATA-binding protein-associated-factor
- Transcription initiation factor TFIID subunit
Sequence:
MSTATTTSTPAQNVDLSKHPSGIIPTLQNIVSTVNMATELDLKAIALGARNAEYNPKRFAAVIMRIREPKTTALIFKSGKMVCTGAKSEDASRFAARKYARIIQKLDFPARFTDFKIQNIVGSCDVKFPIKLELLHNAHTSFTNYEPEIFPGLIYKMIQPKVVLLIFVSGKIVLTGAKVREEIYEAFENIYPVLSAFKKVNAITQ
Protein: Large ribosomal subunit protein uL22c (50S ribosomal protein L22, chloroplastic) (Q6END4)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: This protein binds specifically to 23S rRNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- 60S ribosomal protein L35a
- 60S acidic ribosomal protein P1
- Large ribosomal subunit protein uL23 N-terminal domain-containing protein
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
- Uncharacterized protein
- Large ribosomal subunit protein bL33c
- Large ribosomal subunit protein uL23 N-terminal domain-containing protein
- KOW domain-containing protein
- 60S ribosomal protein L13
Sequence:
MTSFKLVKYTPRIKKKKSGLRKLARKVPTDRLLKFERVFKAQKRIHMSVFKVQRVLDEIRWRYYEETVMILNLMPYRASYPILKLVYSAAANATHYRDFDKANLFITKAEVSRSTIMNKFRPRARGRSSPIKKTMCHITIVLNIVKKSK
Protein: Hexosyltransferase (EC 2.4.1.-) (Q57WM1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MSLSEPRKREFRQRSIARRSICATVLLLSLCTVAIYLTPRRDNGMKHREKAVMQVPSVRSHVVNVPSKYPLWIREALAYVPSTVLRQWEDAEYLVVFGVPSVDINVRRRRRHLQRMTCWAYGGVARRANDFVGSMLPLYILARHPDNNYVFTSAALEEAEKWNDVITLPMNEGRVSTKKQVGQDGKWGVEAEVGMSRKTFMWFDLSLIVFSRAAYIAKGDDDMFLRVPQYLVDLRDLPRRGVYWGTIDRYTVGRTRFNYAFGWCYTLARDVAKQFVSYGPLRKVVNSSSSVLSMFTIKRFYLLAEDAMVGLTLQRAGYASKILYIREKKCSFHNVHAGPTVVAVTDSSVMVHHVREDEYEKLKQRFANERDVAPRFIYSIYEGMKGFSCR
Protein: Chondroitin sulfate synthase mig-22 (EC 2.4.1.175) (Abnormal cell migration) (Chondroitin-polymerizing factor) (ChPF) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (EC 2.4.1.226) (P45895)
Organism: Caenorhabditis elegans
Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransferase activity is weak.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:16982046}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Chondroitin sulfate synthase sqv-5
- Carbohydrate sulfotransferase chst-1
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
- Exostosin-like-3 homolog
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 1
- Probable syndecan
Sequence:
MVGGGRTGIHLLLGFLIGAALALFFFSSTPSIDLTSSLAAFTSCQNQETETNVLEPSALEKGRVYKDLSEHWIVHQDDMPAPPHNQDATPKVTRTRFAATELGTRERVMAAVMAESALALSINATLGRHVPRVHLFADSSRIDNDLAQLTNLSPYKLNGQKTHSMVLGLLFNMTVHNNYDWFLLAKDSTYINPFVLLRMIDTMNWNEPVVMGEAAEDGSGRCRLDTGMLLSQPAMHALMNNRNACNNFALAADDDQLAFEKCIQIATNLTCKPLHQGVRYEVWRGAERADSPAAHDSIEDWKHSPAFKRALAVPRLLSDADASALHDYFVRVEMQRADREIIKMEAELSRLAEQEARETGEAISWPPALPPYAKPPNRYQVSTWEYFTMTELFRSEPNQNVRRLEGKDFDDVAEVVVAARQQVESEEPELEFVQLRNGYRVFDPRRGMDYMVDLTYRKTVNEMPEVDNRFESDNEAAHEESLKEIVVERRVHVSRMIASTQLMNQAPYVKEDTDVTVVIPVASEKDVLPARKLLARQARLCLFPTEEARKTRMVVAVFPLIESRSVTAITNDMEELKRRCKRSLLETDVLPVHPAVSTEGKGTAAAAALDDAVDRYGANTIYLLLSPHADVQKEFFDRARINTIKHYQVFFPVPFVEYHPTISGMEMTEKEEKETPTEQAREAALSRLRDGVEPKRKRTLIVQKEHGRFDSQDFSCFAVYGVDYVTARAKFGQNERRNDLISAFLGQDSIHVLRAVEPTLRIRYHKRSCDMESIDTEDIARCLDSKKENVAAKDQLAKLLFHEK
Protein: Fra mauro, isoform F (Fra mauro, isoform G) (Q9W4B8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
- IP12942p
- Hadley, isoform B
- GH23891p
- GH14155p
Sequence:
MHFKLRLLELIVGLLVVQVKSHPQADPCQNFYKVACGNWSASHATDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFYTACRKPLSQDQVLRILEHLIVMENIQNEELSVGLTAAFRLQVLIDLNDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILPRNSSAQSMVRRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAVDRELDRNPRFQQELGCLRRRFGRKRYEKFADASGLELAYSAYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSDKELLQAHDHGSDRKRVNDAVAHFEPFREAFSCGPSPRRRQCRLY
Protein: SD08104p (Q960C0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWITGQFVFFLLVALVAAKSKTSAVQDDIAEYKDFKKLLRTKNNVLALYVTSAKSAAAELKIFREAAEAIRGTGTMLLLDCGQQDRKKLCKKLKVSPDPYAIKHYKDGDFHKDYDRQLSVSSMITFMRDPSGDLPWEEDPAGKDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPDYGKASTELKTKGGYILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRFTYEGENNKEALVSFMLNPNAKPTPKPKEPEWSADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGLLAALDATKEPSIAEKYKVKGYPTVKFFSNGVFKFEVNVREASKIVEFMRDPKEPPPPPPPEKSWEEEEDSKEVLFLDDDNFSSTLKRKKHALVMFYAPWCGHCKHTKPEFTAAATALQDDPRIAFVAIDCTKLAALCAKYNVRGYPTILYFSYLKTKLDYNGGRTSKDFIAYMNNPPTSADRTEL