wanglab/gogpt-training-data huggingface dataset:
Protein: Actin-related protein T1 (ARP-T1) (Q8TDG2)
Organism: Homo sapiens (Human)
Function: Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:28869610}. Cytoplasm {ECO:0000269|PubMed:28869610}. Nucleus {ECO:0000269|PubMed:28869610}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:31429579}. Note=Both detected in the nucleus and cytoplasm, localizes to the nucleus where it binds chromatin upon stimulation of the Hedgehog pathway. {ECO:0000269|PubMed:28869610}.
Interaction partners:
Sequence:
MFNPHALDVPAVIFDNGSGLCKAGLSGEIGPRHVISSVLGHCKFNVPLARLNQKYFVGQEALYKYEALHLHYPIERGLVTGWDDMEKLWKHLFERELGVKPSQQPVLMTEPSLNPREIREKLAEMMFETFSVPGFYLSNHAVAALYASACVTGLVVDSGDGVTCTVPIFEGYSLPHAVTKLCMAGRDITEHLTRLLFASGFNFPCILNKAVVNNIKEKLCYIALEPEKELRKSRGEVLGAYRLPDGHVIHFGDELYQVPEVLFAPDQLGIHSPGLSKMVSSSIMKCDTDIQNKLYADIVLSGGTTLLPGLEERLMKEVEQLASKGTPIKITASPDRCFSAWIGASIMTSMSSFKQMWVTSADFKEYGTSVVQRRCF
Protein: Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt) (P82931)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:11402041, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS15m
Sequence:
MPRYELALILKAMQRPETAAALKRTLEALMDRGAVVRSLENLGERTLPYKMSAHSQRHTRGGYFLVDFYAPTTTVASIMEHLSRDIDVIRPNVVKHPLTQEVKECEGIVPVPLEEKLYSTKKRK
Protein: C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368) (Q8WXI8)
Organism: Homo sapiens (Human)
Function: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23911656}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- High affinity immunoglobulin epsilon receptor subunit gamma
- C-type lectin domain family 4 member E
- C-type lectin domain family 6 member A
- C-type lectin domain family 7 member A
- Tyrosine-protein kinase SYK
- C-type lectin domain family 9 member A
- Caspase recruitment domain-containing protein 9
Sequence:
MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN
Protein: Uncharacterized protein (Q57ZW1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- HYDIN/VesB/CFA65-like Ig-like domain-containing protein
- Dynein arm light chain, axonemal, putative
- Sperm-associated antigen 6
- Uncharacterized protein
Sequence:
MTESAYLKCSVGPVLAKAVAETVLAQPSNPQEYIALYLLHVLQEEQNAAIAATRQAKVEALRQAWAGRRALREKRAADTIQRFFRQCQAVLRARRAEEEELWNKYEEAEAEADDLLGDVAGEKDHSGDALPDAADVDDAAAAVEDARVEFYKAHRFMLYIRKALLGMLKKELVDRREEVRMEQDKMHDALEVATEEAQKKDEAEAIAAATKGTLPSSDAMEKLVRQVTLRQHEKISAPMILFRVLRCWCYFLFDSTPKQVSTPADVAALLKPFKLMQLLRAFNPVGSYQRSRPLRLEDNLQNANDMNSGDDMQDGDVPIPQPKPRQARRVGRVLRVLLHDGEYICGVNPADHIDAEGSGADEEHEALEAAAAAADRAANITSRVEETAKKHSVILYALLRLLRTASAYRDARDKWLQLLTQAGREVPATVELPEEDVNDPNDEEALRDEDDEVDEAAVRRLLLQIGVDTDEALAKLWIEADSVERAKWEGIAAARLEEEGQEEGSGGDGEGSDGDEGN
Protein: histidine kinase (EC 2.7.13.3) (Q1CWA4)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Sensory box histidine kinase
- Response regulator/chemotaxis protein CheW
Sequence:
MASGPFLPDTAGDMRTPGQRARALGRGFIGWFFVVGLVLATPGMALDPQRRVSQYSQDMWRSDDGLPQNSLLSMVQTRDGYLWLGTWEGLARFDGARFTVFDKRNAPELRNHTIKALAEDASGTLWVGTGQGLVAYRKGHFERAPGAAASLDSARVETLVAADGVLWVGTTTGLWQVPLGEGVARQYTEADGLPASHITALTPGEGTSLWVGTPEGLARWVDGRVEPAPFPFPGPESRPYVMALRRDATGVLWLGTKAGLYSWNGLVASRFTTDEGLPSLSVNALYADGDGNLWVGTHRGGLTRHNSKGFSEPVPGMEWMAESAVLSLLEDRDGHLWVGTYSGLMRLRDGPFATYGIPEGLADETVSAVLEDRRGTLWVGTTSGLFRYENRTFHHVGTEQGLPESVIPAMHEAHDGTLWVGTLTGAYRYDGQRFTRVSRAQGLPHDVVTAILVDSRGDTWLGTQAGLARMHGGGVTVYGPKHGFTNPIIVMVEDSRGRVWFGSDTGLVRWDGEQKGFQRFTQQDGLPGDLVLALHADPDGTVWVGTETGLGRWREDTWARFTVAQGLYDDAVFSLVPDGDGSLWMSSNKGVSRVSRRDLEDVAAGVRPRLTTMDFDTRDGMRSAECNGNTQPSAWRGEDGRLWFTNLRGAIVVDPVRVRESRQPPEVRIEEVRVQGTPVPMEGPVELEPGASRLEIRFTAFTPVDAARLPFRYRLAGHDDTWVHAESRRALYNGLRPGSYRFEVQAKGRDGGWTEPVSLDVVLEPKLWQRTGFWLLCVLGVGILGVSVYLLRVGQLKDRERWLAERVKDRTQALARANAELEANMHTLRQAQAQLVQTGRLAAVGQLAAGVGHEINNPLAYIVSNLEHASEEADALARELDGTRDVGARLKDVNQALRDALLGADRVRRIVQDLKMFSRPDDEKQGPVELHAVLDSAVKIAMGELRPRAKLVRDYGDVPRVEGNEARLAQVFLNLLINAAQALPEGQAGTNEVRLVTRRGPDGRVVTEVRDTGSGISLELLGRIFDPFYTTKPVGVGTGLGLSLCHAYLTAMGGTIAVDSEAGRGSVFRVTLRAAAEAQRVGGDGASVEPPATSDRGVPGAAVPVTPASSGDIATVPDVSVEHGVAASDATTMRLRGEAAPRAELDSTPQASAPERTQGAGWGITPPQAKSTDGRAADSAALAASQENGGRMAAQNASVTSGMSRSSEAGTVGSHQGEPSSTHASAEGSPPDRMGEDGRFSATEAATRGRVLVVDDDALVSGAIRRTLARENDVDVLVSARRALEKLTGTEARYDVVLCDLMMPEMTGMDLYDALAQVDSRAAERIVFITGGAFTATARTFLERVANPRVEKPFDPEALRQLVRSEVARARREASGRAA
Protein: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) (O60658)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.
Interaction partners:
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
- Deoxycytidine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Adenosine kinase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Alpha-aminoadipic semialdehyde dehydrogenase
- Adenylate cyclase type 6
Sequence:
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (ABC23) (DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide) (P20435)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerase I subunit RPA34
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
Sequence:
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
Protein: G-protein coupled receptor 78 (Q96P69)
Organism: Homo sapiens (Human)
Function: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Lysophosphatidic acid receptor 1
- Cyclic AMP-dependent transcription factor ATF-6 alpha
Sequence:
MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVGFVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQQTH
Protein: Pentatricopeptide repeat-containing protein At3g12770 (Q9LTV8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phosphoglycerate mutase family protein
- Beta-1,4-N-acetylglucosaminyltransferase family protein
- Beta-1,4-N-acetylglucosaminyltransferase family protein
- At5g14480
- Beta-1,4-N-acetylglucosaminyltransferase family protein
- Beta-1,4-N-acetylglucosaminyltransferase family protein
- Beta-1,4-N-acetylglucosaminyltransferase family protein
- Beta-1,4-N-acetylglucosaminyltransferase family protein
- Bidirectional sugar transporter SWEET6
Sequence:
MSEASCLASPLLYTNSGIHSDSFYASLIDSATHKAQLKQIHARLLVLGLQFSGFLITKLIHASSSFGDITFARQVFDDLPRPQIFPWNAIIRGYSRNNHFQDALLMYSNMQLARVSPDSFTFPHLLKACSGLSHLQMGRFVHAQVFRLGFDADVFVQNGLIALYAKCRRLGSARTVFEGLPLPERTIVSWTAIVSAYAQNGEPMEALEIFSQMRKMDVKPDWVALVSVLNAFTCLQDLKQGRSIHASVVKMGLEIEPDLLISLNTMYAKCGQVATAKILFDKMKSPNLILWNAMISGYAKNGYAREAIDMFHEMINKDVRPDTISITSAISACAQVGSLEQARSMYEYVGRSDYRDDVFISSALIDMFAKCGSVEGARLVFDRTLDRDVVVWSAMIVGYGLHGRAREAISLYRAMERGGVHPNDVTFLGLLMACNHSGMVREGWWFFNRMADHKINPQQQHYACVIDLLGRAGHLDQAYEVIKCMPVQPGVTVWGALLSACKKHRHVELGEYAAQQLFSIDPSNTGHYVQLSNLYAAARLWDRVAEVRVRMKEKGLNKDVGCSWVEVRGRLEAFRVGDKSHPRYEEIERQVEWIESRLKEGGFVANKDASLHDLNDEEAEETLCSHSERIAIAYGLISTPQGTPLRITKNLRACVNCHAATKLISKLVDREIVVRDTNRFHHFKDGVCSCGDYW
Protein: Histidine-rich metal-binding polypeptide (P0A0V6)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Strongly binds nickel and zinc. Binds other metals less strongly: cobalt > copper > cadmium > manganese. May act to increase, or at least to preserve, urease activity. Exact function is still unknown.
Interaction partners:
Sequence:
MAHHEEQHGGHHHHHHHTHHHHYHGGEHHHHHHSSHHEEGCCSTSDSHHQEEGCCHGHHE
Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) (A0A384MR42)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL
Protein: ATP-dependent RNA helicase HCA4 (EC 3.6.4.13) (DEAD box protein 4) (Helicase CA4) (Helicase UF1) (P20448)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Something about silencing protein 10
- U3 small nucleolar RNA-associated protein 22
- U3 small nucleolar RNA-associated protein 14
- Pre-rRNA-processing protein ESF2
- U3 small nucleolar RNA-associated protein 18
- ATP-dependent RNA helicase HAS1
- Suppressor of glycerol defect protein 1
- Pre-rRNA-processing protein ESF1
- rRNA biogenesis protein RRP36
- Protein BFR2
Sequence:
MAKKNRLNTTQRKTLRQKEDEYIENLKTKIDEYDPKITKAKFFKDLPISDPTLKGLRESSFIKLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEFDGLGALIISPTRELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFELERISRINILIGTPGRILQHLDQAVGLNTSNLQMLVLDEADRCLDMGFKKTLDAIVSTLSPSRQTLLFSATQSQSVADLARLSLTDYKTVGTHDVMDGSVNKEASTPETLQQFYIEVPLADKLDILFSFIKSHLKCKMIVFLSSSKQVHFVYETFRKMQPGISLMHLHGRQKQRARTETLDKFNRAQQVCLFATDVVARGIDFPAVDWVVQVDCPEDVDTYIHRVGRCARYGKKGKSLIMLTPQEQEAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQKAFISYVRSIYVQKDKQVFKFDELPTEEFAYSLGLPGAPKIKMKGMKTIEQAKERKNAPRQLAFLSKANEDGEVIEDKSKQPRTKYDKMFERKNQTILSEHYLNITKAQAQEDEDDDFISVKRKDHEINEAELPALTLPTSRRAQKKALSKKASLASKGNASKLIFDDEGEAHPVYELEDEEEFHKRGDAEVQKTEFLTKESAVMADIDNIDKQVAKEKKQEKKRKRLEAMRREMEAAMEEEISGDEEEGKTVAYLGTGNLSDDMSDGDMPDSEGHLKKKARTVDYSHGHNPSNSVDDDIIEVEEPQTLEDLESLTAKLIQG
Protein: DH domain-containing protein (Q95Q51)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRRSQTVEGSTDSEGGGGTTPTKSSKKERWSFAIKRRWFSSSTSRHSHDHDVAIVQPTKTTLGGTDNNNAESGSVPDRPDDSNASGSTVSKRKSLRRIFANSSKERAAAANSSSSNNNSPATRQSTSTSSPVTANGHTTESSTSAPIGVLSSGEPTSSNSIPSSSTPTHTVPSSVPATVIPIVVAEDEKAEDCLPPPMENITINNSIDEKDMNEDSVAASDAVEPEVALPAKVEKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMDLPADLVGKDKIIFANIVNILEFHKTNFLKEIEKCSENYEAAGAAFVKYERRLHTLYVTYCQNKPKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILKFTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRLQNFDKSLSAQGKLIHQGTLQISESIAGNVQKPKDRRIFLFEQSAIIADHIPPKKEFGNPTYIFKSQFMVNKMVFEPNVPDDPLRFVIKSSDPTQPTSFIANAQSQEEKDEWNRKMSELLDQQKRLLAALVDPRRYNDMSSGMGDLSLGAPGGDRRGAPSSANRSAASSSKKPAESPKKEGKSKSSLFSFGKKPAKSPTSPPPVGK
Protein: WD repeat-containing protein 19 (Q387M5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
- Uncharacterized protein
- Intraflagellar transport protein 122 homolog
- Intraflagellar transport protein 140
- Intraflagellar transport protein 80
- Uncharacterized protein
- Intraflagellar transport protein IFT88, putative
- Intraflagellar transport protein component, putative
- Intraflagellar transport protein A1
- Intraflagellar transport protein 57/55
- IFT80/172/WDR35 TPR domain-containing protein
Sequence:
MSIQKKFELTAEDLDRGVPQFAWDPHSSKLAVYCPNGKVRIISSEGKGLHTFSLPNVSRLGWDPTRAVLALIQQDSSNVSLLMSNEAGPDSIDTGLQGLCFMAWSPVASLLAVGNTGGDLMVINSETMKKVPVTGTHDNRIIDGVWTASNNLVVIGEDQVLSVSDAAGNVQQRVTVKNVPSSLSVIDFPGHGDPSSLANVVALVNCGTVLEHYNLETLQPHVLTFDAKLGNITVCRCLAGGLTCVGFTSGAMALVQINHQNSKVYGVTRPFEDAVCGMSCSGGSGTCVAVAGSSIKFFSLADKRITEIKSDSIQLEGALGALQDVQHSGNGMNITVVTDQPHLISFKRSVPVSSVVCGPNIYSLTGSRTVTVKSVKDDRVVFTATLDMDPTLLAASRDVLAVCSRNTGAYYKAGEGEAKLVNTVNYPSNVSALKVSNNHAAALCDGKVQLHEVWSGADSITLPESGGADVISIGISDSLFMYATPEKIFIVNLADYQCVMEHTPTTGIKRAFPNFSCTRIALIDKYDVMFILNPITLVSTQTEGFEQGHKDILWDQGDYGVLVSYNASTMVTYVYAPHSRYGPTAESVVVKDSKTVNLITNIPSGFTPLGVMKGTVTLQGPCNAVESLTLASHNRATSRVPNSEAFYNNFSLNHLRWASQNISTPQEAEDLAVKALHMLDVELAIRLYRQLSQPSLVMYIESIKHINEKNLLIGHVSMIMGYFKDAQNFFLRSSQPLCALQMRHDLMQWEPALTLAKQLAPEKLPILSKEYAQQLEYRGEYANALEMYRAGEMAMPKGHASTELTAAQGEVKKHNAECLQGSARCLLRTGGVQEGVKLAEQSNDLAFVTECAEILESLRHCDEAAHLYEKALNFEHAAKLYIVDARNLKAASRIIPRITSRNIIGMFAKGKEEEGAFSEAEKAYTQAEDWDNVVRIRVEKLNNLQGAYDIVRQTRSVAAASVVANMCKKRGEFSVAVEFFVLAKAFFEGFELAKEKGCMTALESALLSQVQLTDGVAPAANQNEFSAIARHYEQNVKPGQAGLFYHIAGNFPYALKNYLEAGQPEDIEKAIEVVGRSRSDTLTNKLIDYLMGETDGEPKEPSYIFKLYMALGSYEKAAKTSVLIATKEQEVGSYMAAHRTLVEAFRILRDRKMRVPNDLRRSLMLLHSYVIVKHLIKVMNDDETASRMLLRVVRNIQRFPQHISTLYTSTALQCLKSGFKKSAFDNACIIIQNERYRTELDDKNRKKIEAIVRRRGKEELEDPQEDTSPCPFCDAGVLETELECGSCKNTLPFCIVTGKHMVKQNYSECPVCHFPALYTSFITLLRQSQVCPMCENMVDLNQVQRQIDPDLKTHLL
Protein: Dedicator of cytokinesis 5 (H0Y7N4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
XVNPAEPRFAGPVHLQYHPHLWPLCELQELCLQHRGRCRVVYGPLRPRPVHFYQDLSSMDLIRPRVSLVCQIVRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIHGKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKELQASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLFCKFIQSIPDNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIALLQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEAAYTLLLHAELLQVNGSESLFQQGGVQCPFRLNSIHFMILMGKNFIPGISFYTSFFSSF
Protein: Transcription factor MYB48 (Myb-related protein 48) (AtMYB48) (Q9LX82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:16531467}. Note=Isoform MYB48-2 and isoform MYB48-3 (harboring both NLS1 and NLS2) are nuclear, werheas isoform MYB48-1 (harboring NLS2) and isoform MYB48-4 (harboring NLS1) are partially nuclear.
Interaction partners:
Sequence:
MMQEEGNRKGPWTEQEDILLVNFVHLFGDRRWDFIAKVSGLNRTGKSCRLRWVNYLHPGLKRGKMTPQEERLVLELHAKWGNRWSKIARKLPGRTDNEIKNYWRTHMRKKAQEKKRPVSPTSSFSNCSSSSVTTTTTNTQDTSCHSRKSSGEVSFYDTGGSRSTREMNQENEDVYSLDDIWREIDHSAVNIIKPVKDIYSEQSHCLSYPNLASPSWESSLDSIWNMDADKSKISSYFANDQFPFCFQHSRSPWSSG
Protein: BTB/POZ domain-containing protein 1 (Glucose signal-repressing protein) (P58544)
Organism: Mus musculus (Mouse)
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15486563}. Note=Localizes to punctate or elongated cytoplasmic bodies. {ECO:0000250|UniProtKB:Q9H0C5}.
Interaction partners:
- Cullin-3
Sequence:
MASLGSAAAGEPATGAEAEPGPPAPPPPPPPPPAPSPSALGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTVDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAIVRWAEAECQRQQLAVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISVVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFLFFSSPGNNNGTSIEDGQIPEIIFYT
Protein: TIL domain-containing protein (Q21248)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRLLLLCALIAVASASLFHHHHNKRRILPRHRVRSPATRTRIHVRSERKAEECQKHEHHLICGPERHCDRTCENLFSPPHCLNHLHHAKCYFPRCVCNDGYVRSEKGICIRPSHCPNTYYEPASMLMDETEDNDMMIQFKPVKFSRVGNHRVMRISRKSRVHRPSELAIRI
Protein: Putative amidase AmiD (EC 3.5.1.4) (P9WQ93)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Aspartyl/glutamyl-tRNA
- Probable enoyl-CoA hydratase EchA18.1
- Glutamyl-tRNA
- Acylphosphatase
- Probable enoyl-CoA hydratase EchA18
- Cholesterol ring-cleaving hydrolase IpdA subunit
- Probable methyltransferase/methylase
- Phosphatase Rv3376
- Peptidase M20 domain-containing protein 2
- Uncharacterized protein
Sequence:
MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIERLDPQLKSYAFVMPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAPTAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLSVIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDWSQTTSFDEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETAIAHADTYPARADEYGPIMRAMIDAGHRLAAVEYQTLTERRLEFTRSLRRVFHDVDILLMPSAGIASPTLETMRGLGQDPELTARLAMPTAPFNVSGNPAICLPAGTTARGTPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV
Protein: Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) (P54999)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O59734}. Cytoplasm {ECO:0000250|UniProtKB:O59734}.
Interaction partners:
- LSM complex subunit LSM4
- Cold sensitive U2 snRNA suppressor 1
- Small nuclear ribonucleoprotein Sm D3
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor SNU114
- LSM2-LSM8 complex subunit LSM8
- Spliceosomal protein DIB1
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-splicing factor SNT309
- Pre-mRNA-splicing factor CLF1
Sequence:
MSESSDISAMQPVNPKPFLKGLVNHRVGVKLKFNSTEYRGTLVSTDNYFNLQLNEAEEFVAGVSHGTLGEIFIRCNNVLYIRELPN