wanglab/gogpt-training-data huggingface dataset:
Protein: Putative methyltransferase YMR310C (EC 2.1.1.-) (Q04867)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative methyltransferase YGR283C
- H/ACA ribonucleoprotein complex subunit CBF5
- 25S rRNA
- H/ACA ribonucleoprotein complex subunit GAR1
- Protein arginine N-methyltransferase SFM1
- H/ACA ribonucleoprotein complex subunit NHP2
- 25S rRNA
- Protein-lysine N-methyltransferase EFM2
- U3 small nucleolar ribonucleoprotein protein IMP4
- Ribosome assembly protein RSM22
Sequence:
MSSTRKFKKVEKPLSQTRHYSLCIPTTLVSDCRNLSQITHKVYQVAKFASLFNVSEVVILEDNSQVDATKKKISTAKLILALLQYFVTPPYLRNTVFNEKFRPYLTAASKLPRLSTLPFTRYQKQDHGRYREGLTIKMQKPTLARKKIGKVFKQTKYINIGKSKALALQSQLVPINARVTIDTITRKIVSPQEAYGDFTGLDSQYGYYTRIASSFTDLFMKGPLKEGYTQSVYVPLTTRDTSIPELSSLPTAETNPHILLVFSTWDTLARAFKLDQDQFVDCQGPQEFFDAQLPCPVSNSDVADAIPMTLTTLSTVF
Protein: Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (Protein kinase for splicing component) (Q3MJK5)
Organism: Rattus norvegicus (Rat)
Function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity). Required for RNA splicing, possibly by phosphorylating SRSF1/SF2.
Subcellular location: Nucleus {ECO:0000269|PubMed:16537916}. Nucleus speckle {ECO:0000269|PubMed:16537916}. Note=Colocalized with nuclear speckles throughout interphase.
Interaction partners:
- Cyclin-K
- Cyclin T1
- Cyclin T2
- Cyclin-T1
- DNA damage-binding protein 1
- DNA-directed RNA polymerase subunit
- Cyclin-H
- Cyclin-dependent kinase 13
- Transcription elongation factor SPT5
- RNA polymerase-associated protein LEO1
Sequence:
MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDMAFKSDRRENDERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRLSGSSKRSVEGNDDYGKAQLSKSSSKESRSSKMHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPISSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKLDGKESKGSPIILPKKEKFEVKESGLESKKLPRGIKSEKSTPDTELVNVAHSNTEVKNCLDTGKVKLDENLQKHPVKDLKAQGTKDTKPVALKEVIVTSKETETSEKEALPPLPTITSPPPLPSTTPPPQTPPLPPLPPLPAVPLQPPLPPPQPPFSQVPVSNTSTLPSSPHPRTSTLSSQTNSQPLVQVSMKTQLSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKEMLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGIVIEEQPPSKASRKETTSGTAAEPVKNSSPAPPQPAPVKAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEASSQQQDSESIAPEESLKEVPSVSVVLPPAEQTTPEASNTPADMQNMLAVLLSQLMKTQEPAGNLEENTSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRSHPNRTYGNTDGPETGFSATDTDERSSGPALTESLVQTLVKNRTFSGSVSHLGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQWGGPAQSFGKPYRGAARVPPRGGRGRGVPY
Protein: Probable N-acetyltransferase camello (EC 2.3.1.-) (Xcml) (Q9I8W5)
Organism: Xenopus laevis (African clawed frog)
Function: Plays a role in regulation of gastrulation, possibly by controlled reduction of cell adhesion which is necessary for optimal cell motility.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11397015}; Multi-pass membrane protein {ECO:0000269|PubMed:11397015}.
Interaction partners:
Sequence:
MANVSIRKYKNSDYETVNFLFVEGTKEHLPAACWNTLKKPRFYFIIIVACASIFMCTSSYVLSLTSLVALLAVGWYGLYLEFHGYASRCQREDMLDIENSYMMSDNTCFWVAEIDRKVVGIVGAKPLKEADDELFLLHLSVARDCRQQRIGTKLCQTVIDFARQRGFKAVCLETANIQDAAIKLYEAVGFKKSLVAIPPFLLNQYTSFTVIYYRYDIKS
Protein: Relaxin-3 receptor 2 (RLN3 receptor 2) (G-protein coupled receptor 100) (Insulin-like peptide INSL5 receptor) (Relaxin family peptide receptor 4) (Q7TQP4)
Organism: Mus musculus (Mouse)
Function: High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Relaxin-3
- Insulin-like peptide INSL5
- Relaxin receptor 1
- Prorelaxin 1
- Relaxin receptor 2
- Insulin-like 3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Relaxin-3 receptor 1
- Guanine nucleotide-binding protein G
Sequence:
MATSNSSASLPTLFWVNGSGDSVLSTDGAAMPVQFLVLRIMVALAYGLVGIIGLLGNLAVLWVLGNCGQRVPGLSSDTFVFSLALADLGLALTLPFWATESAMDFHWPFGSALCKVVLTTTVLSIYASTFLITALSIARYWVVAMAVGPGSHLSVFWARVVTLAVWVAAALVTVPTAIFGAEVELWGVCLCLLRFPSRYWLGAYQLQRVVLAFIVPLGVITTSYLLLLAFLERQQRCRPRQWQDSRVVARSVRVLVASFALCWVPNHVVTLWEILVRFDLVPWDSTFYTFHTYILPITTCLAHSNSCLNPVIYCLLRREPQQVLVSSFRALWSRLWPQRKACMEQMALKEVGGRTVASTQESGSSRTHTNTMEHLDEGCSLNTLLSETYQGQSPQILGRSSCSLSQAAVSPGEV
Protein: Bactofilin A (Q9A753)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Peptidase, M23/M37 family
- thioredoxin-dependent peroxiredoxin
- Cytochrome c biogenesis ATP-binding export protein CcmA
- Oxidoreductase, Gfo/Idh/MocA family
- Lysozyme
Sequence:
MFSKQAKSNNKAPARIEPLPTPMAATPAEPARRAPPKVASLLSADLTIEGGVTGEGELQIDGVVKGDVRVGRLTVGETGHVEGSVYAEAVEVRGRVVGAITSKQVRLYGTSYVDGDITHEQLAMETGAFFQGRSLKFQRPAPAPSQPAPHPEHLAIAKSAG
Protein: DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein (H2KMJ3)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSQFGGGKPPGQWHRPAAPGGAPQLSGFSAVNFGGVPMVGMGVPMGMVNQAAFSSQGVLGMQGIMGAVPQQSLPQQQPNFQQQNSLQQGTNMQQNSGAKNQRTFVGVVTKMLDTYGFVDDDVFFQHSVIRGSHPRVGDKVMVEANYNPSMPFKWNAYRIQLLNAATQQEPARQAPQQQQMHQPQRGGQESQRWGAAPASGTSDRADRNGGARGNDSPLHRSSAARRHSPPPRRASPPRRTSSPKRDARPAREIRDSREPREVRRSPPPRRAASPRKASSPSAPAKNDRKRERSPSGSVAPSVRRESASPPRRRARIIPRYECRAQKPALLSPIVSGSVLRHRYSKLYLPSDYVDLSFDWVRSFQLDLSLDLSNPIQFHVFNKDVDFIGEEEIQDLDPEDADHRHQVKVLLLSHAGKSEVVKKAFCLMADGTTDDHQEPQSLLKNLHFLVGARGKETMGIGGSWSPSQDGADPNSATTMIRTAVRTTKSLTGIDLSSVSQWFSMVQIRYYRADKQRIDHVNYLLPDTQSLALDDAQWMLAETKIAEQLKAKLANVDALKIEEDEPPVVMMVEESESVVAAAAAAADVVPEQSIPDVKKEEELQAEEPKVLDNVKESIVLLWVSHFNFAIFFPKIYCALFLFVCVRACVLFVFLSQAFTPN
Protein: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) (P09147)
Organism: Escherichia coli (strain K12)
Function: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. It is only active on UDP-galactose and UDP-glucose.
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Galactokinase
- Aldose 1-epimerase
- UTP--glucose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- UDP-galactopyranose mutase
- UDP-glucose 6-dehydrogenase
- D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
- Beta-galactosidase
- dTDP-4-dehydrorhamnose 3,5-epimerase
Sequence:
MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD
Protein: DNA replication helicase (EC 3.6.4.-) (P10189)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
Subcellular location: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030, ECO:0000269|PubMed:2535726}.
Interaction partners:
Sequence:
MAAAGGERQLDGQKPGPPHLQQPGDRPAVPGRAEAFLNFTSMHGVQPILKRIRELSQQQLDGAQVPHLQWFRDVAALESPAGLPLREFPFAVYLITGNAGSGKSTCVQTINEVLDCVVTGATRIAAQNMYAKLSGAFLSRPINTIFHEFGFRGNHVQAQLGQYPYTLTSNPASLEDLQRRDLTYYWEVILDLTKRALAASGGEELRNEFRALAALERTLGLAEGALTRLAPATHGALPAFTRSNVIVIDEAGLLGRHLLTAVVYCWWMINALYHTPQYAARLRPVLVCVGSPTQTASLESTFEHQKLRCSVRQSENVLTYLICNRTLREYARLSYSWAIFINNKRCVEHEFGNLMKVLEYGLPITEEHMQFVDRFVVPENYITNPANLPGWTRLFSSHKEVSAYMAKLHAYLKVTREGEFVVFTLPVLTFVSVKEFDEYRRLTHQPGLTIEKWLTANASRITNYSQSQDQDAGHMRCEVHSKQQLVVARNDVTYVLNSQIAVTARLRKLVFGFSGTFRAFEAVLRDDSFVKTQGETSVEFAYRFLSRLIFSGLISFYNFLQRPGLDATQRTLAYARMGELTAEILSLRPKSSGVPTQASVMADAGAPGERAFDFKQLGPRDGGPDDFPDDDLDVIFAGLDEQQLDVFYCHYTPGEPETTAAVHTQFALLKRAFLGRFRILQELFGEAFEVAPFSTYVDNVIFRGCEMLTGSPRGGLMSVALQTDNYTLMGYTYARVFAFADELRRRHATANVAELLEEAPLPYVVLRDQHGFMSVVNTNISEFVESIDSTELAMAINADYGISSKLAMTITRSQGLSLDKVAICFTPGNLRLNSAYVAMSRTTSSEFLRMNLNPLRERHERDDVISEHILSALRDPNVVIVY
Protein: Late embryogenesis abundant protein (LEA) family protein (Similar to seed maturation protein PM27) (Q9SKA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- F6D8.10
- Stress-induced protein KIN1
- Probable desiccation-related protein LEA14
Sequence:
MTKLLALSLVLSALFTVGHCTGSEDDIIVRDGHRVVVVEYDRDGETNTRVLISPPGKEVDQKSRDEGEVFGNEKRETASSLPEEEEREHHATPGELICDAIGKCKHKLGTVLGRVKDRTASDLSDETPEMTVAREALEVEEKVSWKAREARGKVNERATKKAHRVQKVLEKVQIAVRGIGTVVATALGLTKIGSVVGIVGIAAAYGMCVWVTFVSGYVLASVLGEQQFGVVQSKMYPVYFKAVSVGILVGLLGHVIGRRRKVFTDAVDMWQSVNLLSSILMVEANASFVYTRATKAMFELIKAEKEDGRGFDTSDQSQSSESAGRTRGKKKVTEKTDEDVVKQRLTKLSERMRKLNAYSSRLNLLTLMSLTWHFVYLGYRLSLTC
Protein: P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor) (Q15391)
Organism: Homo sapiens (Human)
Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- P2X purinoceptor 1
- P2Y purinoceptor 12
- P2Y purinoceptor 13
- P2X purinoceptor 6
- P2X purinoceptor 5
- P2X purinoceptor 2
Sequence:
MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
Protein: Probable WRKY transcription factor 36 (WRKY DNA-binding protein 36) (Q9CAR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
Interaction partners:
- Transcription factor BIM1
- RNA-binding
- Putative F-box protein At1g59675
- F-box/LRR-repeat protein At1g52650
- Gb|AAF63169.1/surp domain-containing protein)
- Transcription factor HY5-like
- Transcription factor HY5
- At5g38760 family protein)
- E3 ubiquitin-protein ligase COP1
- WD repeat-containing protein RUP2
Sequence:
MIKEETVSYFQTFDGVMAESDKEEELDATKAKVEKVREENEKLKLLLSTILNNYNSLQMQVSKVLGQQQGASSMELDHIDRQDENNDYDVDISLRLGRSEQKISKKEENKVDKISTKNVEESKDKRSALGFGFQIQSYEASKLDDLCRQVKLANAENKCVSSRKDVKSVRNENHQDVLEEHEQTGLKKTRVCVKASCEDPSINDGCQWRKYGQKTAKTNPLPRAYYRCSMSSNCPVRKQVQRCGEEETSAFMTTYEGNHDHPLPMEASHMAAGTSAAASLLQSGSSSSSSSTSASLSYFFPFHHFSISTTNSHPTVTLDLTRPNYPNQLPDDYPLSSSSFSLNFSSPDPPPPSSHDHTLNFSGLRTQAPLSTDSLLARYRTRLSGQQ
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (Q9BMT7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIRKSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSVLLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVASEFQTDRVNLWSHILNEK
Protein: Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3) (O43281)
Organism: Homo sapiens (Human)
Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).
Interaction partners:
- Tyrosine-protein kinase Fyn
- Exportin-2
- Caspase-3
- Apoptosis regulator Bcl-2
- Adapter molecule crk
Sequence:
MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQALQFTTLLTSLAP
Protein: Sporulation-specific protein 6 (Q9Y7J1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May act as a kinase regulator. Essential for progression of meiosis II and sporulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10886372}.
Interaction partners:
- Cell cycle protein kinase spo4
- Cell cycle serine/threonine-protein kinase hsk1
- DNA replication licensing factor mcm4
- DNA replication licensing factor mcm2
- DNA replication licensing factor mcm5
- DNA replication licensing factor mcm6
- Serine/threonine-protein kinase plo1
- Origin recognition complex subunit 2
- DNA replication licensing factor mcm3
- Serine/threonine-protein kinase cds1
Sequence:
MDFYSVKSQPFVRSPLVDQNPSIQNINEEVKRDIQNPLSYKTETSDKELCQTAACATSCSDWYPQQQTHMPHQNAFDSAKATAKMALPPTAFSNYCVKPSLTRNKDIPRTSIRVSKLRYWQRDYRLAFPNFIFYFDNVDEEIKRRVTQKINNLGAKVATLFTFEVTHFITTRTTDPEMCQPNDVLYLSKTANMKIWLLDKLLNRILFTLLNSDSLVNTSASCLQSLLDGEKVYGTSDKDFYVPSKNVEYFREYFLCIRDLSQYYKPIAVREWEKTLDSGEILWPSLAITAQGRCPFNTGRRRELKITKHNHPAHEIRKQLLSCTNQTNQNNVVKNSASVLVRQIMGDYNITESAVDGAKQMPTEFPKPENLLPVEKRAAMSPLNLLEPRLINKQNTLANQSPRQPPNAFDADPLAHKKVKIETKSGYCENCCERYKDLERHLGGKHHRRFAEKDENFQGLDDLFLLIRRPIRTN
Protein: Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) (P83362)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:3511473, ECO:0000269|PubMed:8632014}; Multi-pass membrane protein {ECO:0000269|PubMed:8632014}.
Interaction partners:
Sequence:
MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQDSGSEDKKPGERKIKRHAKNN
Protein: Ubiquitin-activating enzyme (EC 6.2.1.45) (Q8IDZ6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-60S ribosomal protein L40
- Ubiquitin-conjugating enzyme E2, putative
- Polyubiquitin
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ribosomal protein S27a, putative
- Small ribosomal subunit protein eS30
- Ubiquitin-conjugating enzyme E2
Sequence:
MNILCIHIVYCFIACLLLCNINQVFTLHVLNYNNGYLYKNLSFSIPLYKNLFQQKTTCKKRKQLLHIKSRGSTYNECSKNCDAYFELNKTNKNITKRIGNIPNVLRKEEKKGRHIINNTKESNNENCRYKEEKNIIINENGDKSFYQGDDIEEDLFNSNLNILESEKKYSRQIYTHGYNEEKKIRGSKIIIIGLNGISCEICKNLSLCGVHEIGIYDNNLLTYEDIDNLYLCNKKLVNEQIKSISCVDNIQKLNESCKIKAITTNLYDNILNYDIVVTVNQKTNFNIKLNNYCRENKKKFICVNTCGLFGRVFIDYGDFYYTNNIDTNTTYDNHNNIISDLYKINNLEFLKNNTIVLSYLPFYNMQLNESDKVKLLLNNNSGKNIQLDNLIIDRICRKNHKIYLSISKNKCNNSIFKIFNHIFQPFFINQLFPYFFNSFFYTYPLNLISYLFKFNKNKFLYNNYSHFFNIKKFVQENKLNYSIRLIKLPEQFRLKYISLEEYIKKQKKKTKIYNIYNNMFNIYNNVFNIYYIYIYIIKNTLKLIKENIRFVLKNIYRKLYGIRKNEHEYKNVDKLKDEEICFMIYDEIMKNKNNKELSDDDIKKFTYLCKKEKKDISNEIINQFCSCAHIELSPFSFFWGALLSQQILKGITHKFKPIHQMFYYDRRDLFPFSNISKMYYGKYMHEKNFFGEEFHKFLKKLNILLIGSGALGCEFLKLLAISGVSSNMDKISNQIHNNKQNNDFNNIKNKDKLDSTSSNLLHTNQNTNVYVPSNMEKKNNHVILQNKENNIQGCVQVVDYDYIEESNLSRQFLFRTKDINKLKCQIACENIKMINDDINCDFLKMKVDDTIFDNKDFLLKRYLLFTNKKNEIVKKQKTKNIRENPLICILCLDNLKSRILMDKFCLLNSIPLIESGIEGLKASSQVVYPFCSETYSSDSNNNTSSSNLFDEEKSNSCTITSFPRNHKHIIEFAKSVYNNMFYENVVKMNKFINDPLYFLGELCKYENILDVNNLLHFFKLTKLFFHFNLHSNIQTLWNSIFVHNILNLLKNSKQEEIVQYFDSLHKLPQPIYFNKDNKYHINFFKYAMNNYKKVFKKFMKIKDEMNEDIFYYKKEDILFTNQQDDSSLSFEKVITNLIEKNNIHMDVRKIFYFLDVIKKNATIQLYELLKKELLELFNNPLFLLSLKYVQNKKLAVNIMRDKTKIPSTLNSGDKLDHRVDTVGEMELNTIRRNIPGNISNKKNNNNNNNNYNNYNNYNNYDNNNVDVDLFCPLIYNLESNKDDINFIYSVTNIRCENYNFKKLNMFDFLKISNNIIPSIVTIVSMISALAFFEMYKIVFFLLNKNKKSKNRSTSYEQKYNVHEKELLKDLNTKKSDHKSELKKVLRHDISNVNVNNNFTESNRSCSNMNNIEMLPYKKLNIYIYNNQIIVRNNDNKNLFYFFNANYEKLKEKSKVIYNQYVNLEDDFITISELKNVDTWTYDNPIFVKKNIFFSIWNYLYIDIFCKNKNVAKDTCPLGCSGINPSHLLDNNNNNNNNNNNNNIYYNTFNILSKEKQNNMKIYINKINEHIEYILNLIKNYKEKENYENNKTYNKEESYNVLVSMLKKICDEYINVIINNIDILSSYVNKKKKNIKENRTTFDDTLQFVLHLKKTLCNIKDKIESINKNNVNPNINIKNNDHNKYISDNIKKLDNKDEREPRISNILFMLNNIKKEIENVKENILKYIDKNNLDVNTYTNNITLNELVESIEIVFNVNIQTICVQDKIIYSKFNIPSFKLYNHKYLYDILCDIFKNDKKFQARELPRTFILSIYAYDKLTNKEVVLPDVQVNVHNHADG
Protein: GM03763p (Q8T9K2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTVFINSRKSPNVLKKQGTDQWVKLNVGGTYFLTTKTTLSRDPNSFLSRLIQEDCDLISDRDETGAYLIDRDPKYFAPVLNYLRHGKLVLDGVSEEGVLEEAEFYNVTQLIAAEGVHPAQGSATPNGQEARLSCAAVPRAGTNPDDLNAVGWLEVRAADQHAVHELRALRKQ
Protein: Sperm associated antigen 9 (A0A8I5ZJK4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSEQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKVSHSPEPLKAVEQEDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGLVKGTDTPNKAEISKHIEVQVAQETRNVSTDSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNAAKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVANGQGENKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVSALESEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSDSGQVDRASLCGSMTSNSSAEMDSLLGGITVVGCSTEGVTGAAASPSTNGASPVIEKPPEVEAENSEIDENIPTAEEATEATEGNAGSTEDAVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGLDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETVILHQGRLLGLRANKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVVSPQSSSSGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
Protein: Annexin Gh1 (Anx(Gh1)) (P93157)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Binds to phospholipid vesicles in a calcium-dependent manner in vitro. Prefers phosphatidyl-serine containing membranes. May have a role in the membrane cytoskeleton scaffolding or exocytotic processes. May be involved in oxidative stress response (Probable).
Subcellular location: Membrane {ECO:0000305|PubMed:16331990, ECO:0000305|PubMed:18441010}.
Interaction partners:
Sequence:
ATLTVPTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELSNDFERLVLLWALDPAERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDINKDLKADPKDEFLALLRSTVKCLVYPEKYFEKVLRLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLAGHVEN
Protein: GTPase activating protein and VPS9 domains 1 (F8W9S7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
Sequence:
MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTEVMGDGESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
Protein: Glycoprotein hormone beta-5 (Thyrostimulin subunit beta) (Q86YW7)
Organism: Homo sapiens (Human)
Function: Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
Subcellular location: Secreted.
Interaction partners:
- Glycoprotein hormone alpha-2
- Glycoprotein hormones alpha chain
- Follicle-stimulating hormone receptor
- Lutropin-choriogonadotropic hormone receptor
- Thyrotropin receptor
Sequence:
MKLAFLFLGPMALLLLAGYGCVLGASSGNLRTFVGCAVREFTFLAKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAHHRVCTYNETKQVTVKLPNCAPGVDPFYTYPVAIRCDCGACSTATTECETI