wanglab/gogpt-training-data huggingface dataset:
Protein: enoyl-CoA hydratase (EC 4.2.1.17) (A7YT47)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
- Acetyl-CoA acyltransferase 2
- Acyl-CoA dehydrogenase very long chain.
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- 3-ketoacyl-CoA thiolase, peroxisomal
- Acyl-CoA dehydrogenase long chain.
- Acyl-coenzyme A oxidase
- Acetyl-CoA acetyltransferase 2
- Acetyl-CoA acetyltransferase, mitochondrial
Sequence:
MASARLLLARGCTGVKSSFTGHGQRSLSVSSAVLARTHVSYEVKDNVAVVRINDPTSKVNTLSKHMQAEMVEVMNEVWGNSSVKSAVLISRKPGCFIAGADINMIQACTTAEEVTSLSQAGQKMFEQIEKSPIPIVAAINGSCLGGGLEFAIACQYRIATKSKKTVLGTPEVMLGLLPGAGGTQRLPKMVGLPAAFDMMLTGRNIRADKAKKMGLVHQLVDPLGPGLKSPEERTIEYLEEVAVDFAKGLAAKKVTLEKKKGLMQKVQDFVMGLSLVRQQIYKTVHGKVMKQSKGLYPAPLKIIECIQTGIEKGNAAGYLAEAQNFGQLAMSSESRALIGLYHGQVACKKNHFGKPEREVKNLAILGAGLMGAGIAQVTIDKGVATILKDTTLEGLARGEQQVYKGLNDKTKKKSLTTFERDGIMSKLSGQLDYHGFEKADMVIEAVFEDLAIKHKVLKEVEAVIPPHCIFATNTSALPIKDIAAASKRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAIGLKQGKLIVVVGDGPGFYTTRCLAPMLAEAVRILQEGVGPKKLDSLTTGFGFPVGLATLADEVGIDVAAHVAEDLGKAFGARFGGGNVDFLKTMVQKGFKGRKSGKGCYVYGAKSKEKKVNSEAEEILKSFKLTAPPAVSSDEDIQYRLVSRFVNEAVLCLQEGILADPIQGDIGAVFGLGFPPCLGGPFRFVDSYGADKLIQKMKRFEEVYGNQFSPCQLLLDHAKNTSKRFHK
Protein: Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) (Q3UHZ5)
Organism: Mus musculus (Mouse)
Function: Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function.
Subcellular location: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q6P5Q4}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:Q6P5Q4}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q6P5Q4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6P5Q4}. Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line. {ECO:0000250|UniProtKB:Q6P5Q4}.
Interaction partners:
- Myozenin-2
- Cysteine and glycine-rich protein 3
- Nebulin
- Nebulin-related-anchoring protein
- Heat shock protein beta-7
- Creatine kinase S-type, mitochondrial
Sequence:
MSTFGYRRGLSKYESIDEDELLASLSPEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGNFSREALMAYWEKESQKLLEKERLGECGKVAEEDKEESEEELIFTESNSEVSEEVCTEDEEESQEEEEDSEEEEDSEEEEETTEATKHINGTVSYNSVNTDNSKPKTFKSQIENINLTNGNSGRTQRNSESPAAIHPCGNPTVIEDALEKIRNNDPDTTEVNLNNIENITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRMQEQKQQEGHDGGAALRTKVWQRGTPGSSPYASPRQSPWSSPKVSKKVHTGRSRPPSPVAPPPPPPPPPLPPHMLPPPPPPPAPPLPEKKLITRNIAEVIKQQESAQRALQNGQRKKKGKKVKKQPNNILKEIKNSLRSVQEKKMEDSSRPSTPQRSVHENLMEAIRGSSIRQLRRVEVPEALR
Protein: Gp130 protein (Interleukin 6 cytokine family signal transduce) (Interleukin-6 receptor subunit beta isoform 1 precursor) (A8WH79)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Interleukin 11a.
- Interleukin-6
- Tyrosine-protein kinase JAK1
- Interleukin 11 receptor alpha chain
- IL-6 subfamily cytokine M17.
- Cardiotrophin-like cytokine factor 1
- Interleukin 6 receptor.
- Ciliary neurotrophic factor receptor
- Signal transducer and activator of transcription
- Prolactin receptor
Sequence:
MDTSHHWLLVLMLLHYAKGSNSSCVLKILPDSKTKIPVELERNFTATCHLQGGSEFTSNDIKWSFSNKETTDILSKTFYHKINETSVSVTVNLSKNMGHMLMCEASRESLTYMGKCAYGIYLDAGYPPMKPKNLTCIALQRKKDISPDLNCYWEPGLRDPLLATNYTLYAQVGQDLYNSTCKQSLARSCTVNLSTYPVHMTLKVWVEVKNSLGSERSDEHEYDSLSLVKPNPPNVEVKVEEDFPTSFVVKWEYDIEDTTMRFSSAIRYCQVGSSDWKKVPENYTNVHITSYRLQSLEPYTEYVVQMRSIGEHYTIWSEWSSNVTVRTPEAREFPLPFLKCVALCEVVNASLYEQTLDLSILTKPPVKANGKMCNYSLIISQDNQAFESHVIKADQLNQRYSLEVPPEENASIEITAFNSAGGSPKTILFIPRSNDEFLGVASMRWWVHDGKLHVEWGPLKQHPPHGIHISEYLLEWVNEKDVQPQWQRVPKNVNTTILNGNLAKYKQYNISVYPIYKFYYDGRWHFQAGTPVTKPAYVQQGAPEKGPTVTDTISKKNSVTLIWEEIPLDHRYGFIQNYTIFYRTGNAEWQSVLVAANIHSYVLTDLVSERDYVVHIMASTEAGSKNGTDFNFKTMKFADGEVEMIVVLVCLGFLFLSVFTIMLCLRKREVIKKLLWPQVPDPSDSSIAHWSPDFPVKTEMPKEDVSVVEVDVFDGKSLCEEDKVVLPLKKDKYLSEEHSSGIGGSSCMSSPRHSVSDSDEGDSGQTTASTVQYSSVVASGYKGQTPNHQPPTFARSESTQPLLDCEEHPENHPGERNSYFRRGRELEPQSIDEPVFSAVQEEEASPVVDDAPALSYMPQQSGYRPQ
Protein: LD21576p (MIP15604p) (Nucleosome assembly protein 1, isoform A) (Nucleosome assembly protein 1, isoform B) (Nucleosome assembly protein 1, isoform C) (Q9W1G7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cytoplasmic FMR1-interacting protein
- FI14118p
- Histone H2A
- Histone H2A.v
- Vig2, isoform B
- Histone H3
- Histone H4
- Nucleoplasmin-like protein
- Importin-9
- Histone H2B
Sequence:
MDAPAEGHVDPESCNEIEDEKSGSDCQSMPAYMNSVMRRQYLQQMVKMLPAPVQNRIVFLKNLQLQHLNIEAQFFEDVYKLEQKYQVQYQPLFDKRREIIEGKVDPAEEKPQWKEPESSTDNEADAEHFREALSSLKSIPKDAKGIPGFWLTVFRNTAIMSEMVQPHDEPAIRKLIDISIKYDNGHSYTLEFHFDKNEYFSNSVLTKQYVLKSTVDPNDPFAFEGPEIYKCTGCTINWEKKMNLTVKTIRKKQKHKERGAVRTIVKQVPTDSFFNFFSPPEVPSDQEEVDDDSQQILATDFEIGHFLRARIIPKAVLYYTGDIVDDEDDEDEEEYDENEEDEYDDDDAPPPKGPKSAGIKKQSPNDCPNQ
Protein: ACT domain protein (Q72BM3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Indolepyruvate ferredoxin oxidoreductase, beta subunit, putative
- Phenylacetate-coenzyme A ligase
- Indolepyruvate oxidoreductase subunit IorA
- Phenylacetate-coenzyme A ligase
Sequence:
MKVEQISVFLENKAGRLAEVTGTLAEAGINIRALSLADTSDFGILRLIVNDHEKAKSVLKDKGFTVGRTNVVAVEVPDHPGGLHGILQTLSGQGVNVEYMYAYVQPGGSNALLIFRFDRTEQAIEVLQQNGIPIVPGEKLYAG
Protein: Interferon gamma (Q5QSL2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDVLSRAVMCFCLMGWMTLGWSNAAQFTSINMKRNIDKLKVHYKISKDQLFNGNPVFPKDTFEDSEQRVLMSVVLDVYLSIFGQMLNQTGDQEMIESLKYVKGKIQDLQKHYFLGRIPELRTHLQNLWAIETSDTTVQGKALSEFITIYEKASKLALKFHLKKDNRRKRRQAQRLKSHIM
Protein: Large ribosomal subunit protein uL13m (39S ribosomal protein L13, mitochondrial) (L13mt) (MRP-L13) (Q3SYS1)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:16510155}.
Interaction partners:
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL19m
- Ribosomal protein
- Large ribosomal subunit protein uL4m
- MRPL41 protein
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein uL14
Sequence:
MASLSRAPQQWATFARVWYLLDGKMQPPGKLAALASVRLQGLHKPVYHQLSDCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFKQVTAAQLHRKDPVAIVKLAIYGMLPKNLHRRTLMQRLHLFPDEDIPEDILKNLTEELPQPRKVPRRLDEYTQEEIEAFPRVWSPPEDYRL
Protein: AmgR (Q9HTY9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- histidine kinase
- Tim44-like domain-containing protein
- Sensor protein
- histidine kinase
- Sensor protein
- histidine kinase
- histidine kinase
- Sensor protein
- Sensor protein
- histidine kinase
Sequence:
MSNPAALAEGEKILVVDDDARLRRLLERFLDEQGYRVRAVENTEQMDRLLSRELFQLVVLDLMLPGEDGLTACRRLREQNNQVPIIMLTAKGDEGSRIQGLELGADDYLAKPFNPRELLARIKAVLRRQAPLVPGAPAGADEVVTFGDYQLFLATRELKKGDEVHMLTTGEFAVLKALVQHAREPLTRDKLMNLARGREWDALERSIDVQISRLRRLIEPDPSKPRYIQTVWGVGYVFVPDGNARKA
Protein: DUF4192 domain-containing protein (O07211)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTKYRGQFELNRPATLIAALPAILGFVPEKSLVLVSLAAGELGSVMRADLCDELADRVGHLAELVAAANPAAAIAVIVDANGAQCPRCNEEYRQLCAALAAALSQRDIVLWAAHVVDRVAAGGRWHCVDGCGCSGVIDDPSASPLAMAAVLDGRQLYPRRSDLQAVIAVDDPVRSAELAVALGHQAADREIAHRADSVGCSRQDVENALAAAARVADGQSLSDTELARLGCALGDARVRDMLYALAVGENAGAAESLWALLARVLPEPWRVEALVLLAFSAYARGDGPLAGVSLQAALCCEPGHRMAGMLDTALQSGLRPEHIRDIAVTGYQRAEQLGIRLPPRRAFGQRAG
Protein: Centrocin 2 (EeCentrocin 2) [Cleaved into: Centrocin 2, heavy chain; Centrocin 2, light chain] (A0A144LVL3)
Organism: Echinus esculentus (Sea urchin)
Function: Has antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and against fungi with minimum inhibitory concentration (MIC) between 0.78 uM and 50 uM. Shows little hemolytic activity at concentrations up to 12.5 uM but >50% lysis at 100 uM.
Interaction partners:
Sequence:
MMIKIAVVLCAVMATSMVFANDVKEQELADLLDLLISEEVSSPDDAVAESWGHKLRSSWNKVKHAVKKGAGYASGACRVLGHSPQEARAKVLEAFPEMKESDLDEEQVGKYCAVAHAIHGR
Protein: WW domain-containing protein WWM1 (WW domain-containing protein interacting with metacaspase) (P43582)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in apoptosis. May play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. Causes impaired growth when overexpressed.
Subcellular location: Cytoplasm. Nucleus. Mitochondrion.
Interaction partners:
- ATP-dependent RNA helicase DHH1
- Poly
- Protein CAF40
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- Coupling of ubiquitin conjugation to ER degradation protein 1
- Deadenylation-dependent mRNA-decapping factor PAT1
- General negative regulator of transcription subunit 2
- RNA exonuclease NGL1
- General negative regulator of transcription subunit 3
- General negative regulator of transcription subunit 5
Sequence:
MAQSKSNPPQVPSGWKAVFDDEYQTWYYVDLSTNSSQWEPPRGTTWPRPKGPPPGVNNEKSSRQQADQAPPPYSSQSTPQVQAGAQAQQPRYYQPQQPQYPQYPQQQRYYPQQAPMPAAAPQQAYYGTAPSTSKGSGHGGAMMGGLLGVGAGLLGGAMLEHAFDDHNYDGPDTVVVENNYYGDDAGGSDGGFDDAGGFDGGFDDGFDGSDF
Protein: V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (PL16) (Vacuolar proton pump 16 kDa proteolipid subunit c) (P63082)
Organism: Mus musculus (Mouse)
Function: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit d 1
- V-type proton ATPase subunit F
- V-type proton ATPase subunit H
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit S1
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit D
- Renin receptor
Sequence:
MADIKNNPEYSSFFGVMGASSAMVFSAMGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANSLTDGITLYRSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK
Protein: SD11312p (Q8MRZ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESRDRKTSNEDDSSEISELDVGSDRFNPLRALYEPNFRVTDAVPKVIYQNLAAFESALKKFGIWQLNKRQKPGSAEGGDQGTSKKASTSEAVDILPPERRFEPHQMPTTSSRKKHHRNIFTYMEAAVGPLELLTKCISPASHNESNERIRVRVVIRKHGSVGGSVEGELLAFDKQWNLLLRNVTETWKRRKYNYGEQNICDTPVDCTGRLKELGITLPRTVVKNLNRKNVEIRRELPQILIRGENVVLVSLIPTK
Protein: UPF0588 membrane protein C20F10.02c (O42972)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- UPF0612 protein C569.01c
Sequence:
MHRAAAVDTTPKIVFYYKCLLNKNWNEPINNIFWGEFFLLQPRLEVLSQLLRECPKQELTVNGPKFHSMYLYISEILKSKAESLRIRNSLATLQTFLAELSVRKPTDVNFTIFLLLGNIDSIDIQFSAFIKNLCQLVKDSEDVQSVEISLRFVLHFVSFLYNSSFISHIYGNYDVFSTLYTVILKRKFGFETAVYAIGLLSACDKFETVNTFRLGLSKIVDEEFFSSVLSSSAQQLISLRDFYVSIKPDNPLTGSFFNLFSLRSSSNNPDSDQESQFSRLPDERATMFFTIYELCCCNKLFLKKLVEGGEKNGEAPLEALLSLLSYINTHQRQSERSHHFSILSLILFHIIIDDRSLLYRLTDKKFKISVRVCSQRYPYPPNATKPATPLGYMLDICCIGIQHNMKLNLSATMYFLYFSFVYRAMTSLVQDGIRMEYHWLELWRVLFSFLDFVSVLINTSPTEDVTRLLELILDVLAYIISNGDALVIRSDELVDLFYKLLHSSKNFSSFSSKIPDERLGALNYLLEVTEYLTSKTVDLPRSTADEVESVIKLELESIPVAKQNAFGGVPPFKESQYRLFHKRASRGMADLLRRKSEAAN
Protein: Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2) (Q9BWQ8)
Organism: Homo sapiens (Human)
Function: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269|PubMed:17635665}. Postsynaptic cell membrane {ECO:0000250}.
Interaction partners:
- Glucosamine-6-phosphate deaminase 2
- Protein transport protein Sec16B
- RNA 5'-monophosphate methyltransferase
- Bcl-2-like protein 1
- BTB/POZ domain-containing protein KCTD15
- Transmembrane protein 18
Sequence:
MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE
Protein: Charged multivesicular body protein 2B (A0A087WW88)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MISAQRNHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
Protein: Fibrinogen beta chain (Liver regeneration-related protein LRRG036/LRRG043/LRRG189) [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] (P14480)
Organism: Rattus norvegicus (Rat)
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Subcellular location: Secreted.
Interaction partners:
- Fibrinogen alpha chain
- Fibrinogen gamma chain
- Prothrombin
- Plasminogen
- Antithrombin-III
- Albumin
- Integrin subunit alpha 2b
- Serpin family F member 2
- Heparin cofactor 2
- Protein AMBP
Sequence:
MRHLWLLLLSVSLVQTQAATTDSDKVDLSIARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKVDAGQKKVERKPPDAGGCVHGDGDMGVLCPTGCELRQTLLNHERPIKNSIAELNSNINSVSETSSVTFQYLTLLKDMWKKKQAQVKDNENVINEYSSILEDQKLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQTEYCHTPCTVNCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSSKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDTKKYCGLPGEYWLGNDKISQLTRIGPTELLIEMEDWKGDKVKAHYGGFTVQTEANKYQVSVNKYKGTAGNALMEGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPVFPQQ
Protein: Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Q9R1V6)
Organism: Mus musculus (Mouse)
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20089912}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:20089912}.
Interaction partners:
- Leucine-rich glioma-inactivated protein 1
- Disks large homolog 4
- Disks large homolog 2
- Leucine-rich repeat LGI family member 4
- Leucine-rich repeat LGI family member 3
- Disintegrin and metalloproteinase domain-containing protein 23
- 14-3-3 protein zeta/delta
- Leucine-rich repeat LGI family member 2
- Contactin-associated protein-like 2
- Potassium voltage-gated channel subfamily A member 1
Sequence:
MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLERQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDVLLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFYDGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRLKRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI
Protein: TAP binding protein-like variant (Q53FW8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLVKDGAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPTIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANVQVSGGGPSISLVMKTPRVAKNEVLWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLSTLICDIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS
Protein: Enhancer of rudimentary homolog (Q22640)
Organism: Caenorhabditis elegans
Function: May have a role in the cell cycle.
Interaction partners:
- Protein tost-1
- Protein pid-1
- Protein pid-3
- Embryonic developmental protein tofu-6
- Eukaryotic translation initiation factor 4E-3
- Schlafen-like protein 2
- Schlafen-like protein 1
- Large ribosomal subunit protein eL19
Sequence:
MSHTILLLQPTDNIESRSWSDYENTTECLEGICRVYEEYLKKKVPAQNEITYDISHLFEFIDDLKDLSMLVLDNTTYTYVPHNKQYVKESIYKLMNNRLNNQH
Protein: Myeloid differentiation primary response protein MyD88 (A5HNF6)
Organism: Gallus gallus (Chicken)
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18582498}. Nucleus {ECO:0000269|PubMed:18582498}. Note=Predominantly cytoplasmic, with some expression in the nucleus.
Interaction partners:
- Toll-like receptor 2 type-1
- TNF receptor-associated factor
- Toll-like receptor 4
- Protein kinase domain-containing protein.
- TLR7
- TIR domain-containing protein.
- Toll-like receptor 2 type-2
- Toll-like receptor 3
- Toll-like receptor 5
- Interferon regulatory factor 3
Sequence:
MATVPVGAGSAPGPEPADLHSVPMVALNYGVRRRLGLYLNPRAATAADWTALAEKLGHDYLEIRRLEALPDPTAALLEEWQSRCPGGATVGQLLELLRQLGRHDVLLELGGSVEEDCKKYLRRKQQEAEQPLQVPAVDSSVPKTSELMGITTRDDPYGHGTEMFDAFICYCQKDLQFVQEMIRELEQTEFKLKLCVFDRDVLPGTCVWSISGELIERRCRRMVVVISDDYLESDECDFQTKFALSLSPGARLKRLIPVKCKTMKNEFPSILRFITICDYTNPCTKKWFWTRLAKSLLLP
Protein: Protein-tyrosine sulfotransferase A (EC 2.8.2.20) (Tyrosylprotein sulfotransferase A) (TPST-A) (O77081)
Organism: Caenorhabditis elegans
Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O60704}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O60704}.
Interaction partners:
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Sulfotransferase domain-containing protein
- Sulfotransferase domain-containing protein
Sequence:
MRKNRELLLVLFLVVFILFYFITARTADDPYYSNHREKFNGAAADDGDESLPFHQLTSVRSDDGYNRTSPFIFIGGVPRSGTTLMRAMLDAHPEVRCGEETRVIPRILNLRSQWKKSEKEWNRLQQAGVTGEVINNAISSFIMEIMVGHGDRAPRLCNKDPFTMKSAVYLKELFPNAKYLLMIRDGRATVNSIISRKVTITGFDLNDFRQCMTKWNAAIQIMVDQCESVGEKNCLKVYYEQLVLHPEAQMRRITEFLDIPWDDKVLHHEQLIGKDISLSNVERSSDQVVKPVNLDALIKWVGTIPEDVVADMDSVAPMLRRLGYDPNANPPNYGKPDELVAKKTEDVHKNGAEWYKKAVQVVNDPGRVDKPIVDNEVSKL
Protein: Type-4 uracil-DNA glycosylase (EC 3.2.2.27) (Pa-UDG) (Pa-UDGa) (Q8ZYS2)
Organism: Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
Function: Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.
Interaction partners:
- Type-5 uracil-DNA glycosylase
- DUF2070 domain-containing protein
- Uncharacterized protein
Sequence:
MDLQKLHELIKNCDKCPLHKYRKNAVPGEGEMKLGVMIVGEAPGASEDEAGRPFVGAAGQLLTEALSRLGVRRGDVFITNVVKCRPPNNRTPNREEVEACLPYLIQQIGILKPRRIIALGLISAKALMELMGRRAEKLGDVKGKCYQGRIAGVQVELCITYHPAAVLRKPALRGEFQKDLAMFFGGGLDRFLDPSK