wanglab/gogpt-training-data huggingface dataset:
Protein: DNA polymerase eta (EC 2.7.7.7) (Radiation-sensitive protein 30) (AtRAD30) (Y-family DNA polymerase H) (AtPOLH) (Q8H2D5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro.
Subcellular location: Nucleus {ECO:0000250}. Note=Accumulates at replication forks after DNA damage. {ECO:0000250}.
Interaction partners:
- Proliferating cell nuclear antigen 2
- DNA polymerase zeta catalytic subunit
- DNA repair protein REV1
- Proliferating cellular nuclear antigen 1
- DNA polymerase zeta processivity subunit
- N-glycosylase/DNA lyase OGG1
- Replication protein A 32 kDa subunit B
- Replication factor C subunit 5
- Replication factor C subunit 2
- Replication factor C subunit 3
Sequence:
MPVARPEASDARVIAHVDMDCFYVQVEQRKQPELRGLPSAVVQYNEWQGGGLIAVSYEARKCGVKRSMRGDEAKAACPQIQLVQVPVARGKADLNLYRSAGSEVVSILAKSGKCERASIDEVYLDLTDAAESMLADAPPESLELIDEEVLKSHILGMNREDGDDFKESVRNWICREDADRRDKLLSCGIIIVAELRKQVLKETEFTCSAGIAHNKMLAKLASGMNKPAQQTVVPYAAVQELLSSLPIKKMKQLGGKLGTSLQTDLGVDTVGDLLQFSETKLQEHYGVNTGTWLWNIARGISGEEVQGRLLPKSHGSGKTFPGPRALKSLSTVQHWLNQLSEELSERLGSDLEQNKRIASTLTLHASAFRSKDSDSHKKFPSKSCPMRYGVTKIQEDAFNLFQAALREYMGSFGIKPQGNKLETWRITGLSVSASKIVDIPSGTSSIMRYFQSQPTVPSRSADGCVQGNVAMTASASEGCSEQRSTETQAAMPEVDTGVTYTLPNFENQDKDIDLVSEKDVVSCPSNEATDVSTQSESNKGTQTKKIGRKMNNSKEKNRGMPSIVDIFKNYNATPPSKQETQEDSTVSSASKRAKLSSSSHNSQVNQEVEESRETDWGYKTDEIDQSVFDELPVEIQRELRSFLRTNKQFNTGKSKGDGSTSSIAHYFPPLNR
Protein: RNase L inhibitor (Q980K5)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Interaction partners:
- Peptide chain release factor subunit 1
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS17
- Translation initiation factor 2 subunit alpha
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS4
- Translation initiation factor 2 subunit gamma
- Small ribosomal subunit protein eS24
Sequence:
MRVAVINYDFCKPDKCNLECINFCPVDRSGGKAIELSEIVKGKPVIYEETCIGCGICVKKCPYEAISIVNLPDELEGEVIHRYKVNGFKLFGLPTPKNNTILGVLGKNGVGKTTVLKILAGEIIPNFGDPNSKVGKDEVLKRFRGKEIYNYFKELYSNELKIVHKIQYVEYASKFLKGTVNEILTKIDERGKKDEVKELLNMTNLWNKDANILSGGGLQRLLVAASLLREADVYIFDEPSSYLDVRERMNMAKAIRELLKNKYVIVVDHDLIVLDYLTDLIHIIYGESSVYGRVSKSYAARVGINNFLKGYLPAENMKIRPDEIKFMLKEVSDLDLSKDLKTKMKWTKIIKKLGDFQLVVDNGEAKEGEIIGILGPNGIGKTTFARILVGEITADEGSVTPEKQILSYKPQRIFPNYDGTVQQYLENASKDALSTSSWFFEEVTKRLNLHRLLESNVNDLSGGELQKLYIAATLAKEADLYVLDEPSSYLDVEERYIVAKAIKRVTRERKAVTFIIDHDLSIHDYIADRIIVFKGEPEKAGLATSPVTLKTGMNEFLRELEVTFRRDAETGRPRVNKIGSYLDRVQKERGDYYSMVLSTQ
Protein: Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (Q9VUZ0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
- Translocon-associated protein subunit delta
- Translocon-associated protein subunit gamma
- Protein transport protein Sec61 subunit beta
- Translocon-associated protein subunit alpha
- Protein transport protein Sec61 gamma-2 subunit
- DSec61alpha
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Inactive rhomboid protein 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Electron transfer flavoprotein subunit beta
Sequence:
MFKHLLTLFALCAVFSTCLSEDETRARLLVSKQILNKYLVEKSDLLVRYTIFNVGSGAATKVRLVDSGFHPEAFDVVGGQPTAVVDRIAPQTNFTHVLVVRPKAFGYFNFTAAEVSYKAVEESETLQLAVSSEPGEGGIVNLNEYNKRFSSHFFDWVAFAVMTLPSLAIPLALWHQSKSKYERSGKNKKH
Protein: Chitin synthase-like protein 2 (O74756)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in septum formation. Has no chitin synthase activity.
Subcellular location: Membrane {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:12914947, ECO:0000269|PubMed:15449309}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:12914947, ECO:0000269|PubMed:15449309}. Note=Septum.
Interaction partners:
- Probable UDP-N-acetylglucosamine pyrophosphorylase
- Chitin synthase 1
- cytokinesis protein 3
- Actin
- Cell division control protein 15
- 1,3-beta-glucan synthase component bgs1
- GTP-binding protein rho1
- Septation protein imp2
Sequence:
MSFQNPSYINAKHRSFLQPKDTQDSQDLRNWVSHSSVDEETAYSSSTLSSSSSKSFPCYDEYDEIKSPDDQKVEYMKTLRTLEEDAFSYTDSVYDFEERSFDEHEPPIPPLHKTGVFSVPLQPTHTVNSNSDDGYENSSKNEYLDFNSEISASPVNEPMTHSQSYTSIDRLNSSSSHYSKDVPLLCGSLTIDCPTPIDLRGMLGPFMQKNPDEASFLRYSAITCQPEDMNNNGLQLRTWSTGRDIQIAVCLTLSDEDLASFAISLSSIMNNLKHLCSRSKSRVWGNESWEKVLVCVVIDGRNTVHQNVLDLLASIGVYQPHIAKGRVNGKRTLSHMYEFTSTINVDEKLNLTTATGDGNVPMQMLLCVKDRRLGTYNSHRWFLNGIASLARPKVCLFVRNGARLGPTSIYHAWKAFDVDSTIGGMCGKTSIDTGKFGFRLLNPFIASQHFDQMIHNNLRLPYDSCMGYISNALNAIYGFRYVALQDSYPNPGPLADYFEQDQYEIPRRGILQSNAFLAQEQLLFWKVITRKDAKWHLQYVPEACATIEAPNSMAGILESKKSEINSSFSLAVYVIVDFFSLWTTRHKFFRFLLLTVQSLVFAIEKLVNFFSMANFFLAFYFVCNATSYSSLNPYGNWARPLFLVFEYILICLIFSQFMLAMGNRPRSCRVLLFISTALFSIIMIYFVFCVFYISLIPLHNSDNSEIVLGNNYFTTLIFSSLLILACYAFVSLICMDPFFIFTCIVQYILLMPTRIYTEQIYALCHLDDASISKDDNQQEFNFDTGITHCSMNDEGYTTISIPKANVLNSVYNSSLKNFSSSNDTSVYHDVQDHCYRKPQSYEDHYQDIRTRYVLVWAVSNLILAIVLIQVFDGMRFINNGYMKYIFWSIVAFTAWKTMGAVTFIATKIISRIANCVKSKLYIFNDP
Protein: E3 ubiquitin-protein ligase RGLG1 (EC 2.3.2.27) (RING domain ligase 1) (Q9SS90)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance. Together with RGLG5, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA. Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling. Acts as a negative regulator of drought stress response.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000269|PubMed:22095047}.
Interaction partners:
- Ethylene-responsive transcription factor ERF053
- Protein phosphatase 2C 37
- U-box domain-containing protein 12
- Ubiquitin-conjugating enzyme E2 13
- U-box domain-containing protein 13
- Ubiquitin-conjugating enzyme E2 35
- BTB/POZ and MATH domain-containing protein 3
- E3 ubiquitin-protein ligase AIP2
- E3 ubiquitin ligase PARAQUAT TOLERANCE 3
- E3 ubiquitin-protein ligase KEG
Sequence:
MGGGNSKEESSSPSSSSWASHQSYPQYGPDSYNYPPPPTYAPAPSPAPAPAPVPAPSPASSYGPQYSQEGYASQPNNPPPPTYAPAPSPASSYGHQYSQEGYASAASQPNYPPPPSQSQVADRKKFDRRYSKISDNYSSLLQVSEALGRAGLESSNLIVGIDFTKSNEWTGAKSFNRKSLHHLSNTPNPYEQAITIIGRTLAAFDEDNLIPCYGFGDASTHDQDVFSFYPEGRFCNGFEEVLARYREIVPQLKLAGPTSFAPIIEMAMTVVEQSSGQYHVLVIIADGQVTRSVDTEHGRLSPQEQKTVDAIVKASTLPLSIVLVGVGDGPWDMMQEFDDNIPARAFDNFQFVNFTEIMSKNKDQSRKETEFALSALMEIPPQYKATIELNLLGVRNGNIPQRIPLPPPVQSGSSFSSSRIPNFEPSVPPYPFESKQMSSADDIQLCPICLSNPKNMAFGCGHQTCCECGPDLKVCPICRAPIQTRIKLY
Protein: Histocompatibility antigen 60a (Q3TDZ7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAKGATSKSNHCLILSLFILLSYLGTILADGTDSLSCELTFNYRNLHGQCSVNGKTLLDFGDKKHEENATKMCADLSQNLREISEEMWKLQSGNDTLNVTTQSQYNQGKFIDGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEQWKNKNLEKDMRNFLITYFSHCLNKSSSHFREMPKSTLKVPDTTQRTNATQIHPTVNNFRHNSDNQGLSVTWIVIICIGGLVSFMAFMVFAWCMLKKKKKRCSLLLLFFCSPHYQL
Protein: DER1-like family member protein 1 (Q12743)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15093775}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15093775}.
Interaction partners:
- U1 SNP1-associating protein 1
- UBX domain-containing protein 2
- Protein OS-9 homolog
- Cell division control protein 48
- Ubiquitin fusion degradation protein 1
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- ERAD-associated E3 ubiquitin-protein ligase component HRD3
- Nuclear protein localization protein 4
- Degradation in the endoplasmic reticulum protein 1
- Endoplasmic reticulum chaperone BiP
Sequence:
MAGPRNVRTLHGNGGRNNDVMGPKEFWLNIPPITRTLFTLAIVMTIVGRLNLINPWYFIYVWNLTFKKVQIWRLLTSCVMLSSRAMPALMELYSIYDRSSQLERGHFGPGLSNRRGPMVTVDYAYYLCFCILAITTATTIIYGSYYPVVLTSGFISCITYTWSIDNANVQIMFYGLIPVWGKYFPLIQLFISFVFNEGDFVISLIGFTTGYLYTCLDTHTLGPIWGMISRKADPTYGISPNGKFSTPWWFTSLYARITGAHNETATFNNNFANVPSSQRETRTFSGRGQRLGTAPATLSQTSGTDSGRASGSQLRSGPSNLNQFQGRGQRVGQTNSPSDSQ
Protein: Surface antigen SasC (C7BUR8)
Organism: Staphylococcus aureus
Interaction partners:
Sequence:
MNLLKKNKYSIRKYKVGIFSTLIGTVLLLSNPNGAQALTTDNNVQSDTNQATPVNSQDKDVANNRGLANSAQNTPNQSATTNQATNQALVNHNNGSIVNQATPTSVQSSTPSAQNNNHTDGNTTATETVSNANNNDAVSNNTTLNVPNKTNENGSGGHLTLKEIQEDVRHSSDKPELVAIAEPASNRPKKRSRRAAPADPNATPADPAAAAAGNGGAPVAITAPYTPTTDPNANNAGQNAPNEVLSFDDNGIRPSTNRSVPSVTVVDNLPGFTLINGGKVGVFSHAMVRTSMFDSGDNKNYQAQGNVIALGRINGTDTNDHGDFNGIEKTLTVNPNSELIFEFNTMTTKNGQGATNVIIKNADTNDTIAEKTVEGGPTLRLFKVPDNVRNLKIQFVSKNDAITDARGIYQLKDGYKYYSFVDSIGLHSGSHVYVERRTMEPTATNNKEFTVTTSLKNNGNSGASLDTDEFVYKIQLPEGVEYVNNSLTKDFPSNNSGVDVNDMNVTYDAANRVITIKSTGGGTTNSPARLMPDKILDLKYKLRVNNVPTPRTVTFNDTLTYKTYTQDFINSAAESHTVSTNPYTIDIIMNKDALQAEVDRRIQQADYTFASLDIFNDLKKRAQTILAENRNNVPLNKRVSQADIDTLTNQMQHTLIRSVDAENAVNQKADQMEDLVNQNDELTDEEKQAAIQVIEEHKGNIIGDIGDQTTDDGVTRIKDQGIQTLSGDTATPVVKPNAKKAIRDKATKQREIINATPDATEGEIQDAINQLATDETDAIDNVTNATTNADVETAKNNGINTIGAVVPQVTHKKAARDAINQATATKRQQINSNREATQEEKNAALNELTQATNHALEQINQATTNADVDNAKGDGLNAINPIAPVTVVKQAARDAVSHDAQQHIAEINANPDATQEERQAAIDKVNAAVTAANTNILNANTNADVEQVKTNAIQGIQAITPATKVKTDAKNAIDKSAETQHNTIFNNNDATLEEQQAAQQLLDQAVATAKQNINAADTNQEVAQAKDQGMQNIVVIQPATQVKTDARNTVNEKAREAITNINATPGATREEKQEAIDRVNALKNRALTDIGVTSTTAMVNSIRDDAVNQIGAVQPHVTKKQTATGVLNDLATAKKQEINQNTNATTEEKQMALNQVDQDLATAINNINQADTNTEVDQAQQLGAQAINAIQPNIVKKPAALAQINQHYNAKLAEINATPDATDDEKNAAINTLNQDRQQAIESVKQANTNNEVDQAATTAENNIDAVQVDVVKKQAARDKITAEVAKRIEAVKQTPNATDEEKQAAVNQINQLKDQAFNQINQNQTNDQVDTTTNQALNAIDNVEAEVVIKPKAIADIEKAVKEKQQQIDNSLDSTDNEKEVASQALAKEKEKALAAIDQAQTNSQVNQAATNGVSAIKIIQPETKVKPAAREKINQKANELRAKINQDKEATAEERQVALDKINEFVNQAMTDITNNRTNQQVDDTTSQALDSIALVAPEHIARAAARDAVKQQYEAKKQEIEQAEHATDEEKQVALNQLANNEKLALQNINQAVTNNDVKRVETNGIATLKGVQPHIVIKPEAQQAIKASAENQVESIKDTPHATVDELDEANQLISDTLKQAQQEIENTNQDAAVTDVRNQTIKAIEQIKPKVRRKRAALDSIEENNKNQLDAIRNTLDTTQDERDVAIDTLNKIVNTIKNDIAQNKTNAEVDRTETDGNDNIKVILPKVQVKPAARQSVGVEAEAQNALIDQSDLSTEEERLAAKHLVEQALNQAIDQINHADKTAQVNQDSINAQNIISKIKPATTVKATALQQIQNIATNKINLIKANNEATDEEQNIAIAQVEKELIKAKQQIASAVTNADVAYLLHDEKNEIREIEPVINRKASAREQLTTLFNDKKQAIEANFQATVEERNSILAQLQNIYDTAIGQIDQDRSNAQVDKTASLNLQTIHDLDVHPIKKPDAEKTINDDLARVTALVQNYRKVSDRNKADALKAITALKLQMDEELKTARTNADVDAVLKRFNVALGDIEAVITEKENSLLRIDNIAQQTYAKFKAIATPEQLAKVKALIDQYVADGNRMIDEDATLNDIKQHTQFIVDEILAIKLPAEAMKVSPKVIQPAPKVCTPIKKEETHESRKVEKELPNTGSEGMDLPLKEFALITGAALLARRRTKNEKES
Protein: Maturase (Q9MV26)
Organism: Oryza coarctata (Wild rice) (Porteresia coarctata)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
PFDKPRNISLSLIQVEIQMEKFEGYSEKLKFPRQYFVYPLLFQEYIYVFAHDYGLNGSELVEIIGSNNKKFSSLLVKRLMIRMYQQNFWINLVNHPNQDRLLDYNNYFYSEFYSQILSEGFAIVVEIPFSLREQSCPEEKEIPKFQNLRSIHSIFPFVEDKFLHLHYLAHIEIPYPIHLDILLQLLQYRIQDVPSLHLLRFFLNYYSNWNSFITSMKSIFFLKKENKRLFRFLYNSYVSEYEFFLLFLRKQSSCLRLTSSGTFLERIHFSRKMEHFGVMYPAFFRKTVWFVMDPLMHYVRYQGKAILASKGTPLLKKKWKCYLVRLWQYSFSFWTQPQRIHLNQLANSCFDFLGYFSSVPINSLLVRNQMLENSFLIDTQMKKFDTKVPATPLIGSLAKAQFCTGSGHPISKPIWTDLSDWDILDRFGRICRNLFHYHSGSSKKKTLYRLKYILRLSCARTLARKHKSTVRAFMQWLGSVFLEEFFMEEEQVFSLMFAKTTYFSFRGSHSERIWYLDIL
Protein: ERAD-associated E3 ubiquitin-protein ligase doa10 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase doa10) (O60103)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Also recognizes the N-terminally acetylated residue of proteins as degradation signal (degron).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cell division cycle protein 48
- ERAD-associated E3 ubiquitin-protein ligase hrd1
- CUE domain-containing protein 4
- E3 ubiquitin-protein ligase ubr1
- Protein OS-9 homolog
- UBX domain-containing protein 10
- Ubiquitin-conjugating enzyme E2-18 kDa
- Nuclear protein localization protein 4
- Ubiquitin fusion degradation protein 1
- Ubiquitin-conjugating enzyme E2 6
Sequence:
MNADDEICRVCRCEGAPDSPLFHPCKCTGSIRYVHQECLVEWLGHSKKTHCELCKAKFEFTKVYSESMPRTIPFTILCRKLASTLKQRVIFFTRVLLTFFCWTVLLPLIFKHVWNLNFKIGDTYTIHARNKTFTAPQKPGYFESISQITSSPRLNTLIANTAEGQVLTFVVTFILITAFLVREWVLQNAVQVADELQGQQFENVNQNNQAQAAAAAAQNLREVREARQRLAMVMEHLRERQEQRNLELQRNGSFEEIERARQRFALLGDNIREPQEEENDVDVDEIFNRQQLNQPALDLNDANSSNSVPVEFNSLHSQNVDYRDEVDSLRPQFNVDEQSSISHSSNASENIVDGAVTQANGIESDFTRVDHEPIIVNNDDENGNNESENEEVIEEDNLNRNVIAEAQNQVVADEERNAVARAAQIAEADDADDFDGILEFLGLRGPITGFLQNCLVIAFVVSVFLTTAVGIPYMSGRLMVEWILFIIHRPTFILRFILSFVNILFDWTVGGAFNIVKILTKLPLLSTVFVKLKLQGIFSSSFQQVSNNMYSWIYDHVFSSSDHAYESLIYYMKTGHKQVVQSFSIFPVFRVCQMFAVILKDFVENYSNRPVDRVFTTLIGYCMFTFLGISYLNRKQFLFNDPQIRNVELAFREVLRQCGSIAKFGIIFSIELVVFPIFCGILLSMCLIGTFKKLAAENLLNVMTVYPAQSIFLAWFIGITFMFEFAVFISMVRKIVRPGVLYFLRDPNDPQFHPIREILEKPMLFQLKKIGFSAILYFAFIIGCVGSVIHLLKSTGIIFPIEFTTKPAVFEAPIDLLALEILIFLSIKLFKPLELTRSFWRTLVSTFCRCLRLSSYVMGQRYSDEEGYYPKQYFSFLRRIISKPSDTENQDDGDKQKAKKDFVQDGFFLWCPSKDVVPVRQGAMLIPVTENGYEIFGEKKKVEENADYTITYAPSNFYKRLIALLLFCWICSTLVTVLLVFVPLSLGRAIYAWCFPNVVKHDFYAYAIGFYSISFPMYAIHASVKFLKLDYLRSLMNKLNLKIVMRSLVMALKYLLLAFLGIFILPLLLGAIWELYVAIPFRTIFNRGTLALDAFQNWVIGLFMLRMIYFTVTSNEERFVSRLFQDAFRDRWTNPQILPLLKNVLIPFTSALIAAVVLPSVFTYVTYPFLSSIFPSASKTLMYRLMHPIFLALLGLALLGRRFVETSSKWSQGIRDDLYLVGTRLHNFGESAPPAISESAEK
Protein: Sclerostin (Q99P68)
Organism: Mus musculus (Mouse)
Function: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 6
- Low-density lipoprotein receptor-related protein 5
- Dickkopf-related protein 1
- Tumor necrosis factor ligand superfamily member 11
- Transcription factor Sp7
- Parathyroid hormone
- Osteocalcin
- Bone morphogenetic protein 4
- Osteocalcin-related protein
- Osteocalcin-2
Sequence:
MQPSLAPCLICLLVHAAFCAVEGQGWQAFRNDATEVIPGLGEYPEPPPENNQTMNRAENGGRPPHHPYDAKDVSEYSCRELHYTRFLTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVRLVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPGARGAKANQAELENAY
Protein: Presenilin (EC 3.4.23.-) (B7Z090)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361148}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361148}.
Interaction partners:
Sequence:
MAAVNLQASCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI
Protein: Ankyrin 2, isoform W (M9PHP8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAQFVTHIQPTLMEASQGHVPHHHGHQVGVQHSSHLPHSGHNMPSPPTHNHHHAHGHGHHTSSGGHHGGAGGHSQKQAAHHSTTSGHAAKGQHHSPPSRIHSPPTEHHPDHVGHYEYFQHQHEQIFHHEGANGGASHKQQTHHHPNKHEHCPTGHQSAGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQVNLFKPRKGVAPEKLRKISVNHVPKKKRFSLIW
Protein: protein disulfide-isomerase (EC 5.3.4.1) (H0Y3Z3)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}.
Interaction partners:
Sequence:
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTGFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
Protein: Protein angel homolog 1 (Q9UNK9)
Organism: Homo sapiens (Human)
Interaction partners:
- Tubulinyl-Tyr carboxypeptidase 1
- Protein O-mannosyl-transferase 2
- Eukaryotic translation initiation factor 4E
Sequence:
MIASCLCYLLLPATRLFRALSDAFFTCRKNVLLANSSSPQVEGDFAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEENAASEDRWSSRQLSDLRAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQPPAVEIPYHEILWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERRKYGRDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVGTIQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHRLYRDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASFGMEVTAP
Protein: Protogenin (Protein Shen-Dan) (Q2VWP7)
Organism: Homo sapiens (Human)
Function: May play a role in anteroposterior axis elongation.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMPMIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQPGTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLSSVISTTPPNL
Protein: SH3 domain-containing protein (Q54DS6)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- ELMO domain-containing protein F
- ELMO domain-containing protein E
- RasGTPase-activating protein
Sequence:
MASVSSSSSRLSVSTPRKLDEWTNVTKTGIVLFPFNATHKFQLPLSVGDFVQIHAQTSQEQIGWYSGVSVTTQESGIFPQSFVVILPEQTDIDDPLSLPNHIPICSKLTLTNDEMSNSSIVNEITSTIVEWATLLKIYSTGKQYNEFKVLSQKISQLVQYRNQILLYKSPKEITYDLRDRILSVIDEGRRDTGMTIVLRKEIPNTYSSLACQQASQRTSINIPPTVATDLILADAENSGVFTLCTMYQEKKLEIVALNNSFRDSFEYDSLEISGANLNNSLNNVNSNNNNNINNSNIAAAGGLQSSLSTNNLLNGANVILSQSPSPMNSSSTATSLSQQQSPNSSSIGQSPISSGQSSPTNSSSTTLPGSSPSNGNNILGSSMNGGGGIGGANGSPLSNSNKDLQFSSSQSQTSILQQTQSQSQLIQQQQQQSQQQQQQQQQQQQQVQYSSSPSSQSSSSFSSSPGNSSFLSSKLNKQGSSKNFLSNVLLKSKGSSSSTSSLSMSGGMLPPSNGSPNGLNSSGGFSNHGNGLSNSNNGIQPSSSSSSSPSSSSPSSSSMVSSSYVSVSAQSPSSISSPNVNGGLNQSLSSLNLNSPILSNSPNKKMQTIKMKSRQYLLQQQQIQQQQQQQQGGNSNSSGGNSNNNNNNGEMITKFNSQLLISLNNFLYSSGDNIDIVLSIYNRSENKFLSESYCGIVPPHGIFVEPENPNERIRTIFRDLELKDLNSDLYLVAKLYRKTNSLSSKDPNSSPTLTRSNANMSSSSNLNNLGGPTKLFRKFVGCGVKRLDLSNEGVSELMITLNTTSSENNFYNLHEQIINEQTTIYEPITRAKGVVFTVQLFTGDYQQFLQEFPDFRSVTTSLKLQLPEVVLPGGERNDMYIQLEEGDFSDKNIEVQLQVRTESGQIIHDAIKFANGQSSTSEFKTPLIPSALCKWNEIVKIWVTAKTFEKSHLFFLFRQCSEKKDKERQTIGFGYLKFMSDEGSIIKDQQYTINVYKSNTDDVPVSSYINGGVVDNEKSSKSTKKLDSIKVRTTFVSNCLTQNPSVVNLSRWQQYGGDLSSLIKDITFLNSQDLVRNLQEIFYNFLSILDQQLNDSPLSMEIFRAIVFIIGVLVESRTSNYRPALDLYASKYFGTPLSSSNNKQDSFTGITAHTHLLRSVVKNLENFEIPANASKISSSLKALEYIFKLVVASKTKFTANKMDTLGGSNNESYQTNLKSVVDILCEIMLSGSPSLIGAKTIALKNFESMFTDLKKFFTVEEMGIIALKFMKSIQHDEKKKTFSILKLKLLSSYINGPMMLCKETRKQLLPLVFQLLHFHFSKSSEETDMCLMILGLIVDIMITKSELRGKDKDPWLMEMLHFFVPILELLQLLNNGNNINNLTTTNNTTTTTTTTTTTTTTTTTTTTTTTNSTVDEKRKSLSSITSQLSIMISTMNEENQNNLRIKIYAFILGTARLSGVQHWEMVNKSVTQLNKNFFINLYDSLQLIFESPKFPSDFWTFTVFQLKTILRMTRILEDVIFYLPSNVVPAATATATSTLTNNNNNSNNNNSITITNNNNNNNNNNNNNNDIGSSANTGGSGNSLINQSQFEFTQWRSFFLLTSSYLNCKDLQFESVNPAKAVFIKTRCGDVRIEMARVFERVWATVPIKERSTFIPVLIGPIVKLSISDTMDAKRVATKIFYDMLESEIIQTNGYTDLFYHTIDSLLEISTERLNRKGWPIVCRSVDGKLPFTLRSFSTFFNVKCMSLVLNKSTDAIKTKSEQFIHDINHFLYLITSFMNDVKSGDEEEIFSSVSKLLYYLQEHKRTAHFIRFVHMTSRRHYEMGNYIEAAVTLMLHASLYQWDANKVIAQTASEYGSFPEQKESERKELLYKEILLCFNNGKAWDRAIPLVKELVHHFTMNICDMNSAATYLRQQGAFYQKINESADPVFEDYFRVGYYGKGFPSSIQNKEFIYKGNQFDRLSDFISKIQDKWPKSELLKTTEVPSQQIQDSDGQYLLITSVNISNIGETQKRHDSANAESITNKKRVPHRVQQFNARNKVNVFVYSKPFKKNATATKSQNEFEDLWVMNLYFVCENSFPCTERRCLIVERKQVEISPIENALNSIVQKNDELAARIDRHQANTQESISPLTMLLNGIIDASVNGGVSRYETFMSEDYLKQNPEYKNIAELLKSALDQQLVIVEQGLKLHSQLRPPEMAAMQDKLETFFITMKNSRQKLN