wanglab/gogpt-training-data huggingface dataset:
Protein: Toutatis, isoform A (A1Z8M2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNKNAGDGSDGKNSNKNSNAGGGGGAGGPHDPTGLLDAASLFAYWGRDPTGAAAAAASNPLFNSQFNAAAAAGLGLLPQAGGASANDRYSMAAAAAAAAGAHHHQNTMAVAASQAASLAGLHPASWWSMAQLAAQDYFSRLQASGLSPFPHPDLAAAFGPAGMGMGGGAGGAGAGGGGAGVLGQGGGGNGGSGNGGGGSSSGSSGSKSNKSRKEKRAAQQQQQQQQNLANSLNAAAAAAAAAAANNPAAALASMHGFGVGVPGTSIPSVSTGSGSISTNSGGHGSYKSTASAYGKPSTMTSSSMANNPGSAYDPVTLHKELLAMQAVAAAASGSGSSGSSGKKSGGGGSSSSSMHSLGMGIGGSGGMMSSGKASTSVSASNSSLGGMHPSLTSSNPLMSPHAGMGSSSSSSSKDRDKNNPSLNALNSLSQFGALGMTPQQSMQAAMNAFAASTGVSPSATVTSSPHHSSQQQQQMGGNSSTSGSGKSSSKDYMMGTGSEHPSLLGVRLPPDTEIIKYTSSIVGPKIPGTTSRGRKKTISETEQQTTQQQQKQQHQAEQHLLQQQQQAQKELDSTKNAISSLLAFPGLSPAKRARLEMEYAAMAAAAQQQHQQAQQQHQAQQQLHGMLGAAGIPGMAGLVGLPGMSGNPLDQLSVSKASSSTAPTTSTSSSSAGSNLLNQSNSDRVEVIKLPPTITSNGAYNLSSKGKEVHDLTTDMATNSGGVNLSLKSNAGSSALTPSGAVGSASNPITIDDFDAPLNLSMKPSDKSNSSSSNAAAGGSSSSSAALANLASDYQAASSGQSGNSLQSLSSITAALGGTGGMPGGSISGSGGTSPAPAGAGSGATGGGSGSGGSGGGSSSYKEGRPRNLGRGVSKPKKNTVASLLAQSRAVGLKPMLATQQLLQQGADIEKIRLALSEANAHMETSTDSESVAAESGLSESESEDANILNVAELRVPLELGWKRETVIRGLTKQGQIRGEVTYYAPGSTTPLKSNGQVFAILEQQPSNLSRENFSFSARAIVGSFLQPAPPPYANDGEYIRMTDEDVAKRLEDLKVFTRQTLNVEQRIEIAKQQQAMRDAKKLQKEELARNKEKARQEKNSKLEQQRKDKELKNQQAVEERKKRQEELDRLKQEELLKKQQEKEKRRQEAILAKEQELQKQKEMLLAAEMERERRRQHMSLIRMLELRRKFEDREKKKHQLVLDRLLLRERRMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFLHNFGETLGFDMESLPSLQNLHDALMSDSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADITNSNVSEILRIYLYATATGEVRQMHGITVDRERERRVPDHHQLDSDTTTHSHSVKNQEYYKLLHENDTWKLSQSLKDRPFVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGTDGEATKGGSPNGEKPEDGDQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTDNSLTPSKQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLSDLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWRRYWKLPKAGGIFIEALESAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDDVTEINKVEPEIVDLGDDDDDAAPPLPKIEPPRPEIKVKSEMELMGPPPTTMISTKTDFEAEIKIPSMPGILMPPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQELQISYANQNCSAQLQLQGHPWDLINNMQYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPDEHRLLEQVKLAGFPERVHGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRFLGLEQPLGVNYKLKSDIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKANCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLLMQASPTATALHVNACQSPPQQQHAQLMTMPSPPAIGVGTATNQMSPPPINIHAIQEAKEKLKQEKKEKHATKKLMKELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKFFESRWGELTDKHS
Protein: Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (O95398)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:10777494}.
Interaction partners:
- Ras-related protein Rap-1A
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Ras-related protein Rap-1b
- Adenylate cyclase type 5
- Mitogen-activated protein kinase 7
- A-kinase anchor protein 6
- Adenylate cyclase type 1
- A-kinase anchor protein 1, mitochondrial
Sequence:
MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
Protein: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta) (O15120)
Organism: Homo sapiens (Human)
Function: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21873652}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Seipin
- Membrane-bound glycerophospholipid O-acyltransferase 2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
- Phospholipid phosphatase 2
- Phosphatidate cytidylyltransferase 2
- Phospholipid phosphatase 3
- 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
- Phosphatidate cytidylyltransferase 1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
- Lysocardiolipin acyltransferase 1
Sequence:
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
Protein: U6 snRNA-associated Sm-like protein LSm8 (O74483)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable component of the spliceosome.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- LSM complex subunit lsm2
- LSM complex subunit lsm4
- LSM complex subunit lsm7
- LSM complex subunit lsm5
- LSM complex subunit lsm6
- LSM complex subunit lsm3
- U4/U6 snRNA-associated-splicing factor prp24
- Pre-mRNA-processing factor 31
- Small nuclear ribonucleoprotein Sm D2
- U4/U5/U6 small nuclear ribonucleoprotein prp3
Sequence:
MSLADFMEQRVQVITNDGRVVLGSLKGFDHTTNLILSDSFERIISMDQDMETIPLGVYLLRGENVAMVGLVNEELDSEIEWTKIRGEAIPDVVH
Protein: Curli production assembly/transport component CsgG (P0AEA2)
Organism: Escherichia coli (strain K12)
Function: May be involved in the biogenesis of curli organelles.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Curli production assembly/transport component CsgE
- Curli production assembly/transport component CsgF
- CsgBAC operon transcriptional regulatory protein
- Major curlin subunit
- Minor curlin subunit
- Curli assembly protein CsgC
Sequence:
MQRLFLLVAVMLLSGCLTAPPKEAARPTLMPRAQSYKDLTHLPAPTGKIFVSVYNIQDETGQFKPYPASNFSTAVPQSATAMLVTALKDSRWFIPLERQGLQNLLNERKIIRAAQENGTVAINNRIPLQSLTAANIMVEGSIIGYESNVKSGGVGARYFGIGADTQYQLDQIAVNLRVVNVSTGEILSSVNTSKTILSYEVQAGVFRFIDYQRLLEGEVGYTSNEPVMLCLMSAIETGVIFLINDGIDRGLWDLQNKAERQNDILVKYRHMSVPPES
Protein: TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) (Q92804)
Organism: Homo sapiens (Human)
Function: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
Subcellular location: Nucleus {ECO:0000269|PubMed:19124016}. Cytoplasm {ECO:0000269|PubMed:19124016}. Note=Shuttles from the nucleus to the cytoplasm.
Interaction partners:
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 13
- Heterogeneous nuclear ribonucleoprotein A1
- TAR DNA-binding protein 43
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 4
- Matrin-3
- Nuclear receptor subfamily 4 group A member 3
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 2
Sequence:
MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY
Protein: Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (Q9Z111)
Organism: Mus musculus (Mouse)
Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 4
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B1
- Proliferating cell nuclear antigen
- Large ribosomal subunit protein mL64
- Growth arrest and DNA damage-inducible protein GADD45 alpha
- Cellular tumor antigen p53
- Growth arrest and DNA damage-inducible protein GADD45 beta
- G2/mitotic-specific cyclin-B2
- G2/mitotic-specific cyclin-B3
Sequence:
MTLEEVRGQDTVPESTARMQGAGKALHELLLSAHGQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGADEEGGAPGDLHCILISNPNEDTWKDPALEKLSLFCEESRSFNDWVPSITLPE
Protein: Large ribosomal subunit protein uL3m (54S ribosomal protein L9, mitochondrial) (Q9P6P6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Mitochondrion {ECO:0000250|UniProtKB:P31334}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein uL6m
- Large ribosomal subunit protein uL2m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS17m
Sequence:
MQSRFLISPTLIRTFAHHANLTPRKILHDLPEAAHARKQIPLRPGVILVKKGMTNAWDEKTGMQVPLTILQFDRVQAIDVRTKEKHGYYAVQVGSGIRKPKSITKAEQGNFFSHNIYPKMHVREFRVRDASGLVSPGTIFTTDYFKPKQYVDVKGITKGKGFAGVMKRWGFSGGNASHGASLSHRTPGSTGQNTTPSRVLPGRKMAGHMGHRSRTVKNLLVWAVDADLECILVKGSIPGPNKSAVYVTDTINRSTSATN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q57W25)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein LTV1 homolog
- Glycogen synthase kinase 3
Sequence:
MSVELRVGNRFRIGQKIGSGSFGEIFRGTNIQTGDPVAIKLEQVKTRHPQLAFEARFYRVLNAGGGVVGIPNVLYHGVEGEFNVMVIDLLGPSLEDLFSFCGRRLSLKTTLMLAEQMIARIEFVHSKSIIHRDIKPDNFLMGTGKKGHHVYIIDFGLAKKYRDARTHQHIPYKEGKSLTGTARYCSINTHIGIEQSRRDDLEGIGYILMYFLRGSLPWQGLKAHTKQEKYARISDRKQTTSVETLCRSFPAEFAAYLNYTRSLHFEDKPDYSYLKRLFRELFVREGYHVDYVFDWTLKRIHDTLQEGRADQQQQQQQQQQRRGSEKEDEHPV
Protein: Cell fusion protein fus1 (Q10719)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells.
Subcellular location: Cytoplasm.
Interaction partners:
- GTP-binding protein rho5
- GTP-binding protein rho1
- Profilin
- Formin-3
- Cell division control protein 12
- Actin
- Myosin-52
- Glucan 1,3-beta-glucosidase 3
- Tropomyosin
- Ascus wall glucan endo-1,3-beta-D-glucosidase
Sequence:
MMTASFKGIRISKPIVKEISSFGSLTNIDLHTDPYEKVEAKALSRSRLKNQSVKKTDLRITNDYSSLFVSIENKKNTIPDIHCNNLSKRPVGFTDSYVPGEALLCPDDPNLVNELFDDVLKRLREEKSDSGEQFHWDANVTLSQENKWSFITGYLSRNDKFLKISSNDSELNVKASVISYIEKLSCTPLKLKYVESLAVALRTESVTWVRYFLLMGGHIVLAKILQAIHEKKHLKSPDITLEIAILKSMRCIIGQKIGTDFYLSNKYPIDSVVHCLLSTKLLVRKLAAELLTFLCYSEKPNGINAIMKCMKNFANLKVESMNVFDLWLSQWKRTLLEKVVTEEKKVLEEAALHDKITIEYIISQMLLINAFLENIPSKTALLQFKESLRIGNFKSILLILKKINDEGVLKQLEKCVKLVSLDTANEKHFLKHTPNSAAHQSLLNTNMFNDANFEFMVKEHIKNFLKLLKEHNNPVRIIKLLDCLVLTLQADKGNGNSNNDIDCFYKELKIGNEQGNNAPGYSSVTSGYGTTNSKKVVASYDNTDDNEYSVSKSELYATGDTNNTTNQGYENSERKYVESSKYETDLKNIFDCLCLLFPSEFDPQSSFSAEKIFSKLKHLLTRTRDSYISEDTKILRLLNRSSSKLQDRDQEYLISKNNVNGNGNRDWVQPVNTTSSVSAFASPRIKPKLLFQPNQDEKLKLCKLDLAKANSITLKSEPSSAVSTHSFEVHLSMPGTQIKSANLAEKMETSKHKVFNPKRIDVVSDLPLDYRKSYYGRFSITDTKRFSKIENMRIKEVIDGNPFKAPPPAPLPPPAPPLPTAMSSLQKFEKNDSQIFRKTIIIPENISIDDIFKFCSGSESEVYASKIPGELCNPSKRLKQLHWKRLEVPFEKTLWNIVVADPYLLTLKLTAEGIFKQLEDCYPLREVTVSNKKVKEYTGFMPVDLQQMVSIRLHRFNSLTPIEIAKKFFHCDHDIMELVDFFNDRKFFRQEGLKKQLKPYMSSRNEEVMEVSEKLLELSRFDQIYTLIVVDIDTYYEKRMAALKIKSFLANNFRDFRRQIRKLHCASLELKSSLHFKYFLNLVLHIGNFMNDAPRRAKGYRLESLLRASMIKNDKTGLTLLHTIEKIVRTHFPQLEAFLVDLKAIPEISRFNLEQLEQDCNDICERMKNVEKDFSNEGIFSNHKALHPDDHICEVMVPWIPSGKSMVDELNSDITELKTTLKTTLLMYGENPDEPTSSARFFNNLNEIILEYKKASTVNQKMEKEEELAFLRLQALKASVKSNNAENSGSSKNEEVSATMENLISQLQKGLCDDSLSNKTDCTESSKQTIETLMNYENDKQTLEGSNKKRQTVVLKAECMLKQLENNNELKR
Protein: Interleukin (Q575Z3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MTGFLTVLLFCIRLLERRTKKSVRWICLFWGFHYYPHQRLNIELWNCFIILSCLSATAHLPIAGAAETHGMTIDDVKELQSELKNLKSTIEKSDACLYAPTNDDIYNDHCIFKFMHCYLLELEVVLFEDMSVTDNYHDEIKTSIYHRKKHLEEHERQYNSSRCSPCEAQRVANSTIFLYNLERLLERIGQTVS
Protein: Protein BLISTER (Protein KOLD SENSITIV-1) (Q9LIQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Is required for normal leaf, flower and seed development and controls cotyledon and leaf patterning by inhibiting premature differentiation. Regulates the expression of a subset of PcG target genes. Is required for the repression of the floral specific genes PI, SEP2, and SEP3, but also for the activation of FLC. Involved in response to cold. Involved in the regulation of COR15A, COR15B, BAM3 and AMY3 transcripts, and ascorbate levels in response to prolonged chilling temperatures.
Subcellular location: Nucleus {ECO:0000269|PubMed:20647345, ECO:0000269|PubMed:20674078}. Cytoplasm {ECO:0000269|PubMed:20647345}. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000269|PubMed:20647345}.
Interaction partners:
- Histone-lysine N-methyltransferase CLF
- UDP-glycosyltransferase 76F1
Sequence:
MASATSSRRQEDVEAGRRKLEQFRKRKAAEKAKKASQNTQPVDNSQQSVIDSDGAGASISNGPLKQSAESTSNETHTKDVYNLSFSNTAMDDGSKERSRQDDGQESVGKVDFSNSLELIGSSKDLTVNTRPEVVPYSNIDKQSSESFDRASTLRETASLFSGTSMQMDGFIHGSGLTSSRKDSLQPTTRMAGSFDEVAKNQQGSGELGGSIVQKPTLSSSYLFNSPDTSSRPSEPSDFSVNITSSSPLNSAKSEATVKRSRPSFLDSLNISRAPETQYQHPEIQADLVTSSGSQLSGSDGFGPSYISGRRDSNGPSSLTSGASDYPNPFEKFRSSLYPAANGVMPGFTDFSMPKQNDDFTALEQHIEDLTQEKFSLQRDLDASRALAESLASENSSMTDTYNQQRGLVNQLKDDMERLYQQIQAQMGELESVRVEYANAQLECNAADERSQILASEVISLEDKALRLRSNELKLERELEKAQTEMLSYKKKLQSLEKDRQDLQSTIKALQEEKKVLQTMVQKASSGGKSTDLSKNSTSRKNVSTSTEGLAISDTTPESSNQETDSTTLLESDSSNTAIIPETRQLTLEGFSLSVPADQMRVIHNINTLIAELAIEKEELVQALSSELSRSAHVQELNKELSRKLEAQTQRLELVTAQKMAIDNVSPEKQQPDTHVVQERTPIADEGDEVVERVLGWIMKMFPGGPSKRRTSKLL
Protein: Protein CUSTOS (P0DPK0)
Organism: Xenopus laevis (African clawed frog)
Function: Essential for Spemann-Mangold organizer formation and subsequent anterior head development in the embryo. Inhibits canonical Wnt signaling pathway by antagonizing nuclear import of beta-catenin (ctnnb1) during embryogenesis.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:25157132}.
Interaction partners:
Sequence:
MAAPRRGTQKSDSDSSDEDLDRFREAAWVPPGAHQKVSDEQNEKIALPSLRVRPDCHEHDGNELQTTPEFRSHVAKKLAAILDSSIREVSQNEAVHISKAGNGDSEDEGFRLFRTSLPGEAGIVTSTIPRRKLASSSSEDSEEEQQRCREAAVSACDILRHSTLQQEPQSTPSNVCDNQPPKKKRKKKKKDRGDTSQINSVEETMHIEPGKNELQAKRKKKKKQKLEMAHCDELGNE
Protein: Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (GAL4 DNA-binding enhancer protein 2) (P38879)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. Nuclear import may occur via redundant pathways including one requiring the karyopherins PSE1 and KAP123, which also participate in nuclear import of ribosomal subunits.
Interaction partners:
- Nascent polypeptide-associated complex subunit beta-2
- Nascent polypeptide-associated complex subunit beta-1
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein uL22A
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL14A
- Large ribosomal subunit protein eL13B
Sequence:
MSAIPENANVTVLNKNEKKARELIGKLGLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGNYVVFGEAKVDNFTQKLAAAQQQAQASGIMPSNEDVATKSPEDIQADMQAAAEGSVNAAAEEDDEEGEVDAGDLNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLSK
Protein: Cyclin-A1 (Q61456)
Organism: Mus musculus (Mouse)
Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Note=In oocytes at least, it associates with the spindle during metaphase.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase inhibitor 1B
- S-phase kinase-associated protein 2
- Cell division control protein 6 homolog
- Transcription factor E2F1
- Cyclin-dependent kinase inhibitor 1
- G1/S-specific cyclin-E1
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 6
Sequence:
MHRQSSKSGVALPPVGQGPDACQMLSRAQLGQDPPQRTVLGVLTENEQYRRTCGQEITAIRCFSGSENVFPAAGKKVLSDHGVNEPAKRGFDIYMDDPEQGDRDTCSGKEGIIFEDVYEVDTSMLKSDLHFLLDFNTVSPMLVDPTTHAQSEEATDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPPVVLPLQ
Protein: Protein FAM222B (Q8WU58)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALAHQGLQHPHNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRVPTGYPSDLKPVTWNQHQLAHLQQMCSEASGTPAPGLTGKHAAGRELAGPGFVGKAPAYPQELCLAQSFHLKPPLEKPTPSPPVNGMAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAMPFHGGQPTGAPLDCAAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTESRSLHIQHPGYR
Protein: Bifunctional adenosine 5'-phosphosulfate phosphorylase/adenylylsulfatase HINT4 (APS phosphorylase) (EC 2.7.7.5) (EC 3.6.2.1) (5'-adenylyl sulfate phosphorylase HINT4) (Adenylylsulfate:phosphate adenylyltransferase HINT4) (Histidine triad nucleotide-binding protein 4) (Q84VV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses adenylylsulfatase activity in vitro, releasing AMP and sulfate from adenylyl sulfate. Possesses also adenosine 5'-phosphosulfate (APS) phosphorylase activity in vitro. Catalyzes the phosphorolysis of APS, leading to ADP and sulfate.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19329564}.
Interaction partners:
- ATP sulfurylase 2
- ATP-sulfurylase 3, chloroplastic
- ATP sulfurylase 4, chloroplastic
- ATP sulfurylase 1, chloroplastic
- At3g57910
- CASP-like protein 5B1
- Uncharacterized protein At2g39910
- Adenylylsulfatase HINT1
- Cytochrome b-c1 complex subunit 10, mitochondrial
- 5'-adenylylsulfate reductase 1, chloroplastic
Sequence:
MAGVNQACIFCEIVRNPTTTRLLHTDEKVIAFQDIKPAAQRHYLVIPKEHIPTVNDLQRRDEDYSLVRHMLSVGQQLLQKDAPQSIHRFGFHQPPFNSVDHLHLHCFALPYVPRWKAIKYKSLGPLGGFIEAETLLEKIRPLLSKV
Protein: Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) (P07451)
Organism: Homo sapiens (Human)
Function: Reversible hydration of carbon dioxide.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18618712}.
Interaction partners:
- Carbonic anhydrase 4
- 1,25-dihydroxyvitamin D
- Solute carrier family 2, facilitated glucose transporter member 5
- Carbonic anhydrase 1
Sequence:
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK
Protein: Arrb2b protein (Arrestin, beta 2b) (Q7T2D2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Protein smoothened
- G-protein coupled receptor 161
- Beta-arrestin-1
- G protein-coupled receptor kinase
- Kinesin-like protein
- G-protein coupled receptor 161-like
- GLI family zinc finger 2a.
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase
- GLI family zinc finger 3.
Sequence:
MGDKAGTRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVDGVLLIDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFISSFQAYPPLPDERKPLSRLQERLLKKLGQNAYPFNFTIPQNLPCSVTLQPGPEDTGKACGVDFEVRAFCAKTVDEKTHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQVEADDQVSSSSTFCKVYTLTPTLSNNREKRGLALDGQLKHEDTNLASSTIVKDVSNKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPSEQPNSRPQSAVPETDVPVDANLIEFETNNFSQDDDFVFEDFARLRLKGMKDEEDDHFC
Protein: Chs4p (A0A1D8PK97)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- chitin synthase
- Bni4p
- Protein OS-9 homolog
- Chs6p
- Chitin biosynthesis protein CHS5
- Derlin
- Chitin synthase export chaperone
- chitin synthase
- chitin synthase
Sequence:
MGDHPYRHVSNTAPYPTQDIGPSESSSSNPPSMTEVTSGLEDLHLPPNQNKNYGSGNIVNQSVNMPPQQPPGSNMQLQSISPRDQAQFNQQNIQSQRPISPRPPNQRSNNSSSSQRSFQQIQQQQQQQHQNQQQFSPSIKYASDGYSNSPYSPMDSNNLYQQDQFKASPTLNATPVKSPPVDAPYPVYDAPSPPPVFASKESIVISPPSVPLSATSSVTNLNLNQADIYHSQSENNLAVHTGNKFGHNRSVSSTSSFFYDRSDNASMIDFNQNMIQSYLGANSSHLLPRIKTLELYRKNAKKSTDPNVLFQYAQYMLQTALLLESELQNMVNNGNGNGNGSQNGNIAGINNATSSSQSSGSQNGTNSPFTRSIENSPRKGPLDNTTTTTTNGTKDKHTKSKSIDFNNIELEGNEKKLKKALLKEAVKYLKRLSDKGYVEAQYLLADAYSSGALDKIDNKEAFILFQSAAKHGHVESAFRTSFCYEEGLGTGRDSRKAVEFLKIAASRNHPAAMYKLGVYSFYGRMGLPANDMNTKKMGIKWLTRAANVATELTAAAPYELGKLYYNGFEDIVLIDKKYGLELFAQAAALGHLQSAAILGHHYEIGEIVPQDSNLSIHYYTQAALGGDPNSMLAMCAWYLVGSEPYLPKDDNEAFEWAKRAANCNLPKAQFALANFYEKGIGCIKNINEAQSWYKKAAENGDEKSLKRLTDKELVKTIQKQWKKKPPVIHNEDGTSTTNSGSLAQEKDCVIM