wanglab/gogpt-training-data huggingface dataset:
Protein: Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) (Q8R3L2)
Organism: Mus musculus (Mouse)
Function: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12107429, ECO:0000269|PubMed:18068114}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BQ70}. Note=Mainly nuclear. {ECO:0000250|UniProtKB:Q9BQ70}.
Interaction partners:
- E3 ubiquitin-protein ligase listerin
- Ribosome quality control complex subunit NEMF
- Transitional endoplasmic reticulum ATPase
- Protein spire homolog 2
- Differentially expressed in FDCP 8
Sequence:
MSRRALRRLRGEQRGQEPLGPDALKFVLLDDDDAEEEGPKPGLGGRRPGGAGKEGVRVNNRFELINTEDLEDDLVVNGERSDCTLPDSVSSGNKGRAKHGNAETKQDGGATKAGSSEQSNASGKLRKKKKKQKNKKSCTGESSENGLEDIDRILERIEDSSGFSHPGPPPLSSRKHVLYVEHRHLNPDTELKRYFGARAVLGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFAFDHNEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLIERALYSMECAFHPLFSLTSGTCRLDYRRPENRSFYLTLYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPEHELSSARQQASLLIQQALTMFPGVLMPLLEYCSVRPDATVSNHRFFGPDAEISQPPALGQLVSLYLGRSHFLWKEPAIMSWLEENVHEVLQAVDAGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPSDVTTQSVMGFDPLPPLDTIYSYVRPERLSPVSHGNTIALFFRSLLPNYTTEGERLEEGVAGGPNRNQGLNRLMLAVRDMMANFHFNDLEVPREDNPEGEGDWD
Protein: Anaphase-promoting complex subunit 15 (20S cyclosome/APC complex protein apc15) (O94688)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
Interaction partners:
- Anaphase-promoting complex subunit 4
- Mitotic spindle checkpoint component mad3
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 13
- Anaphase-promoting complex subunit 14
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- Anaphase-promoting complex subunit 2
- RING-box protein pip1
- Anaphase-promoting complex subunit 5
Sequence:
MSFMSLMANTAHQLWYPTSFPSMKELEKEEVRLETQELAIKQFGFRTIRPIGLNRSMQEQLDLEEQEREEANQDTELDEEELGSGSFPEEGEMDDMDGDNEEVEDHDIEEVDLDADITNADASEFYEDISEYGFQN
Protein: Metabotropic glutamate receptor-like protein B (Q86HH3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Frizzled and smoothened-like protein B
- Frizzled and smoothened-like protein K
- 4-aminobutyrate aminotransferase
Sequence:
MKNLISIILLILIFFNYSKFVKSKNCKIAVLLSGDFSDLGYNYQFNEARVKAESILKLSDFSLYYKNLDESEELSEASFKDAIAQGANLIVVASSGQTEMGLKYAKLYKDSDIYWIIKTSARPVDYLPKVAVLDFNTDRAHFTLGYFAGKMSKTGVVGFVSPGAYIASNGNAFYLGAKEARSNITFVTTFTGSWFNPEVAYKAAEMLISNGADFLGMSQDDMSVQKAVIDSGSLGLGVTGYPTRLIYGSANIGLSYITDWTDVFVKYASHVINDTWPDSDYYKTSLNPGGSLLFDEYSYLVPQSIRDLVNNEIEILKNDDFNPFRCNPMYIDLGYKLDVNGCISYNEFEKNQQVLKGDKYSKTISFGTYTIPIEFVDYSSSMKLGITITSSICIFLCIISIIIVLVFRTARIIKSASPAFLFLILMGCILIFIGCIIFSQSPNEGTCRARVWLLSIGYTIFLGSLLVKNWRIWLLFDNPKLKKRSITNWKLYPWVAGILAADVLILAFWQGLGNIRSESRIGIDSLTKYQYTNVCSSNDQGSIALYILLVFHGIKLLVACFISFKIKVVDIDEFNESKPIASSVYIITFCLFIVIPLMVSPQSVTSQVTTICVCAIVTTLISIILLFGSKFYKMITQGAALNQTFASSSKSSSFSQSLEKKKTGEEDDSESSEENGKKAIVVTQQSVLAHFSSDTEDDENETQQIDEEKDEQIAGSNEDIIQPEENIEENNVSVIQSKRLSNQLNGEVEIDSNNL
Protein: Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) (Q9Y394)
Organism: Homo sapiens (Human)
Function: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum (PubMed:24246760). However, it was later shown to be facing the cytosol (PubMed:28457967). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}.
Interaction partners:
Sequence:
MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD
Protein: Uncharacterized protein (Q38CH9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVVNTRVSPNARARPPPRRPVNQHHLPPLQPTTSLQPLHSPHVRKTSEPAYRRGSTRNCCSVSATPVGADVVHYRAGNVEKDDPVSYAAKHQLPLLLNSMIRDLLRERPEVDVDGWIMRWFEREYEEQKRVNKQRLEASTVVNTAEPTKPEPQQGHRQPSLPLNEKWISQPFVTTVQKDVQPTTIISTTPSNMSSPTVVISLPQRRLSTEVMRTSTPSSLDSRSCTIVMHPPEDRKANLLQLETSHPTFTKFPSISSVSVAPTIIVPRSLPQQQERRPQRIGEEKEQQQMIVIRMPRPVDCRTKMRTTQYLDINGNDGAAPKAT
Protein: Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4) (Q96T53)
Organism: Homo sapiens (Human)
Function: Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity. In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C7A3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0C7A3}.
Interaction partners:
- Appetite-regulating hormone
- Growth hormone secretagogue receptor type 1
- G-protein coupled receptor 39
- Agouti-related protein
- Pro-neuropeptide Y
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
Protein: RNA-binding protein 6 (Q3TPF1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLKRIYRSTPPEVIVEVLEPYVHLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGNRNSDWSSDTNRQGQQSSSDCYIYDSTTGYYYDPLAGTYYDPNTQQEVYVPQDPESPDEEEIKEKKSTSQGKSNSKKETSKRDGKEKKDRGMTKFQESTSEGKPPLEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQAPPVQPRTAQPREEMTKKENEDDKLTDWNKLACLLCRRQFPNKEVLTKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKEKGNDRREKLQSFDSPERKRIKYSRETDSDRNPVDKEDTDTSSKGGCAQQATGWRKGAGLGYSHPGLGSSEEIEGRMRGPGGGPPGRTSKRQSNETYRDAVRRVMFARYKELD
Protein: Trace amine-associated receptor 2 (TaR-2) (Trace amine receptor 2) (G-protein coupled receptor 58) (Q9P1P5)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5QD04}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE
Protein: Keratin-associated protein 12-1 (High sulfur keratin-associated protein 12.1) (Keratin-associated protein 12.1) (P59990)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MCHTSCSSGCQPACCAPSPCQASCYIPVGCQSSVCVPVSFKPAVCVPVRCQSSVCVPVSCRPVVYAAPSCQSSGCCQPSCTSVLCRPISCSTPSCC
Protein: AT02057p (Uncharacterized protein, isoform C) (Uncharacterized protein, isoform F) (Q6AWD5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004283}.
Interaction partners:
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- Dynamin associated protein 160, isoform D
- AP complex subunit sigma
- Hillarin
- Adaptor protein complex 2, mu subunit, isoform A
- Amphiphysin
- Cdc42-interacting protein 4, isoform B
- AP complex subunit beta
- Clathrin heavy chain
- AP-2 complex subunit alpha
Sequence:
MTVDFNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAGTLNSTFAPVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVAVQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKPEMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALRAGNAATTASGSAVSMDQRGDALAAISLGSGSAASGSIPFAEDPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTAKQQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSEDTSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLNEQEHLQQTAAATAATTAAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLDRGNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPNAGALTNSASITAPGAASGTGTGYEVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQERRIHVSIKPLKNGQAPMSASVDELRATVENISLSPTGVFSHHSQQLQAARGAPASRQQSPEISNASTPTASVHPYAPLQSPTLSNNNNANNTTNSRYADLGDIFSELGDMSMSAPSSATLGKPPGRQIPTPTSASTGGSIAIPRPPSRRSDMIAIGPAATGTAPGRGRMSPAPVTAMNRAESIGSLEFRTAIGGVGSSRGPSPLTIGISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAKLGFRIKHVQNLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILKYQVRTKPGASSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASPLLNVTLSVPVNGSVRNVQSKPHSAWLGESNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPALLATQFNCEGTTLSGIEFELQGSGYRLSLVKRRFVSGKYVCEGDGIRSGATPTPPSVGSTSPYSAKSN
Protein: Myosin-14 (Myosin XI H) (AtXIH) (F4JM19)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
Interaction partners:
Sequence:
MACTTVNVGSCVWVEDPEVAWIDGEVIEVKGSDIKVKCTSGKTVAIKVSSAYPKDVEAPASGVDDMTRLAYLHEPGVLQNMKSRFDINEIYTYTGNILIAVNPFRRLPHLYNNHMMQQYKGAGFGELSPHPFAVADAAYRQMKNQGISQSILVSGESGAGKTETTKLLMQYLADMGGRAVSEGRTVEKKVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPPEDIKKWKLADPRKFHYLNQSQCIELERMDDAKEYRETRKAMDVVGINSEEQEAIFQVVAAILHLGNVEFGKGKEADSSAPKDDTSNYHLKTAAELFMCDEQALEDSLCKRVIVTRGETITKCLDQESAALSRDALAKTVYSRLFDWIVNKINDSIGQDPDSEYLIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQDEYNKEEIDWSYIEFVDNQEILDLIEKKAGGIISLLNEACMFPRATHETFAEKMYQTFKDHKHFSKPKLSRTDFTICHYAGDVTYQTEQFLEKNKDYVVAEHQTLLNASRCAFVASLFPLLAEDANKKSKFSSISSRFKQQLVTLLETLSTTEPHYIRCVKPNNLLKPLIFENQNVLQQLRCGGVMEAIRISCAGFPTRKKFEEFLERFSVLAPEVLDKSTDGWPLSSTDDVACKKLLEKVALQGYQIGKTKVFLRAGQMADLDARRNEVLGRAASRIQRKFRSYLSRKTFLMLRKVATNMQAVCRGQLSRLIFEGLRRDAAVLEIQRDIRMHLARKSYKELYFAAVSIQLGIRGMASRGRLRFQRQDKAAIMIQSHCRKFLAQLHYQRLKKAAITTQSAWRARLARKELRKLKMAAKETGVLEAAKSKLEKQVEELTWKLQLEKRMRTDMEESKTQENAKLRSALEEMQLQFKETKALHLQEVEAAKKMAETVPVLQEVPVVDTELVEKLTSENEKLKSLVSSLDQKIDETEKKFEERSKINEERLKQAIEAETTIVNLKTAVHELQEKILDVESENKILRQKSLIQASGHLPPTPVKGSQNGHFSSKESPFNGSEIETLARTQEQESDAKTRRYHLDRQRENIGALINCVVNNIGFNQGKPVAAFTIYKCLLHWKSFEAERTSVFDRLVQMIGSAIKDEGDNEHLAYWLSNTSTLLFMIQQSLKPGATPQQKTPVSTSLFGRMAMGFRSAPSSAETSAAAEAAAAAVIRPVVAKDPALLFKQQLTAYVEKIFGMIRDNLKNELQTLLSLCIQAPRTSTGRSLRSFRSSKTMRNNSPLDHWNGIYDGLNAILSTLQENFVPPVLIQNIFIQTFSFINVQLFNSLLLRRECCTFSNGEFVKSGLALLEEWCNETTEEYAGSSWDELKHIRQAVGFMVIHKKYRISYDDIAHDLCPILSVQQLYRICTLYWDDSYNTRSVSQDVIANMRVLMTEDSNNADSSAFLLDEDSSIPFSADDLSSSMKEKDFAEMKPAEELEENPAFSFLI
Protein: Maltose fermentation regulatory protein YPR196W (Q06595)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May regulate the transcription of maltase and maltose permease genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
- Uncharacterized protein YPR195C
Sequence:
MSIVRQSCDCCRVRRVKCDRNRPCDRCRQRNLRCTYLQPLRKRGPKSIGESNLERAAEIQMVTVNNNIMAAPVMYKKVPKKVIDQCLRLYHDQLYVIWPMLSYDDLYKLLEENYEDCSTYWFLVSLSAATLSDLHTKIEYKKGFFFAGEQLCNLCMSSRRFFDDLSNSDIFRIMTYYCLHRCYAQFADTRTSYRLSCEAIGLIKIAGFHREETYEFLPFGEQQLIRKVYYLLLMTERYYAVYIKCVTSLDTTISPPQPEIVTDSRLSLDSFLEVIKVFTVPGKYFYDALATNSVNGSYTEDSLKRIWNELHISSLDIEPYSYGYIDYLFSRHWVRTLAWKLVLNKKDMRMNFFSNTNATHIPVEIAKDMLQDTLLTPIDLYDVHGPVIPMKALEIANALVDVVSKYDHNMKLEAWNILCDVSKFVFSLKHCNHKMFQRFSTKCQSALIDLPISRPLRLNDDSKDEVDIIP
Protein: Neurotrimin (hNT) (IgLON family member 2) (Q9P121)
Organism: Homo sapiens (Human)
Function: Neural cell adhesion molecule.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Heat shock factor protein 4
- Opioid-binding protein/cell adhesion molecule
- Major prion protein
Sequence:
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q584Z8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RecQ mediated genome instability protein 1 OB-fold domain-containing protein
- Exonuclease, putative
- DNA repair protein RAD51 homolog
- Endo/exonuclease Mre11
- DNA repair protein, putative
- non-specific serine/threonine protein kinase
- DNA topoisomerase
- DNA topoisomerase
- DNA repair protein RAD50
- Flap endonuclease 1
Sequence:
MQNSYEEILFDDVASDNTPSEGEALTPVNVELVHDEKNNTEEEKEEEEYLMRVPFLAPRRASTFCNTPPSDHRNNSNGLTVCHVAHSVPQDENPVGLPANAAFPMNCIRKGVDEDDKSILQVTLERLFKETPRSNTSTIPICSYLLQSHLGVSSGEFREGQQEAVLAILQGESTLAVFPTGWGKTLCFQVPILVHRLLFQQKLMLWKQKQLENVSLPEYTAPCSRFGVVVSPLLSLMADQVERITKDGSLKAVILSSATSGARDKDLLESLSSPVCNIDLVFLSPEKIVRHRELRQVLKGQVHRIAFICIDEAHCVSQWAYDFRPSFLYVHRVLEDIVLGGDFSPPFLCLTATATPSVIDDLQSTFNIRRTVVVPYQRANLQLEAVSLLSENVTKDSPPTHSDLREKLLQTVLELPKPMLVYVQTRADADELAKFLSSKLGAAQNGKARKKGDKTRSLLFTSATHEKIQNGTVENITSGVEGRPLVIQSYHAALERHARTKCQNQFMHDRIDVLIATVAFGMGIDKPNIRSVVHASVPSSIESYVQETGRAGRDGKLSICRLLYNPYDFYALRSRLLSSLVSPTEMLSVVTHILSSPVTRFGDKLIVVSVSKISEELMMSEETVETVLFMMLTLESGVLTACHGTSPTGYRVIRWSTEINTTTSGKRKRDRDVQSGVGSALAQLEALDGVFETCRNNKRMESVVNAANALNMSLNDFNFRLDDLSASGFVSLQKLPTGYVITVGDRFVEVSSPTARQELATRLWSLYNNRLESLVKSLELTFAVLRCPTHDSVRAGLEWDPRRNLSSEFLLQKEGIPCWQAPRRSLTKVDAVMTLNDFVEKNRTRINGSYEAARALLGVLPKSLTSRGKYAGELPLALSWYVRSPHFGLLREFDLQLILKLLTPHNLDEKEET
Protein: Glucose transporter 13a (Solute carrier family 2 member 13b) (C3RUD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEDQRAYARVEDESTLIKTASKRDHELQPGPPCFVYTLAFFSALGGFLFGYDTGVVSGAMLLLKREKKLSSVWQELLVSITVGAAAVSALAGGFLNGRFGRRVCILLASFIFCAGGIILSVARNKEALLCGRLTVGLGLGIASMTVPVYIAEVSPPDLRGQLVTVNTLFITGGQFIASVVDGAFSYLPHDGWRFMLGLSVVPAALQFLGFLFLPESPRWLLQKGFTQNALLVLRQIRGDVDVEEEFESIRCSIQEEQRDVAGGPVLWRMLASPPARRALIVGCGLQMFQQLAGINTVIYYSSLFTCTAVSLMVLAAGFLLSAQASPPVTFHPSNPSIHNSTCGNYGFCESCMLDPDCGFCYGLNATAVVQSSCVPVDPANTETAALGRCFNGTQKASSVFWAYNYCPTPYSWVVLLGLILYLAFFAPGMGPMPWTVNSEIYPLWARSTGNACSAGVNWICNVLVSLTFLHVAQYLTYYGAFFLYAALALLGFVFVSGCLPETKGLRLEEIESLFSRRLCSCGAHTDQYMRVNGGNSRSDEDEDEEE
Protein: Probable serine/threonine-protein kinase WNK3 (AtWNK3) (EC 2.7.11.1) (Protein kinase with no lysine 3) (Q9STK6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate flowering time by modulating the photoperiod pathway.
Interaction partners:
Sequence:
MRQDENNSEEEFVEIDPTGRYGRYKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKCYKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDWTPSRLIGDDSAVQKCLSSPETLHLDRFPSGRKFWSSPKAGAGDSRSPFAPRSNSKLSSAQGPINQEVGVIVEKLESLLRKQREEIEEMQRDQERIVTEFLKEFPPEICEEALVRLQVKDSDNLLC
Protein: Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (Q6PBY1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P97351, ECO:0000255|HAMAP-Rule:MF_03122}. Nucleus {ECO:0000250|UniProtKB:P97351, ECO:0000255|HAMAP-Rule:MF_03122}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P61247}.
Interaction partners:
- Small ribosomal subunit protein eS17
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL13
- Ribosomal protein S10
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL39
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- Small ribosomal subunit protein uS10m
- Large ribosomal subunit protein uL23
Sequence:
MAVGKNKRLTKGGKKGAKKKIVDPFSKKDWYDVKAPAMFNIRNLGKTLVTRTQGTRIASDGLKGRVFEVSLADLQNDEVAFRKFKLVTEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRTNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSVGKDIEKACQSIYPLHDVYVRKVKMLKKPKFELGKLMELHGEGGSTSAAAKPAEGDTGAKVERADGYEPPIQESV
Protein: Precursor of CEP5 (PCEP5) [Cleaved into: C-terminally encoded peptide 5 (CEP5)] (Q058G9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signaling peptide that represses plant growth rate. Regulates shoot gravitropic responses. Represses primary root length and lateral root initiation, probably by repressing the CEP receptor CEPR1. Regulates systemic nitrogen (N)-demand signaling. Mediates up-regulation of genes involved in N uptake and assimilation pathways.
Subcellular location: [C-terminally encoded peptide 5]: Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}. Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
Interaction partners:
- Receptor protein-tyrosine kinase CEPR1
- Receptor protein-tyrosine kinase CEPR2
- Precursor of CEP9
- Precursor of CEP15
- Precursor of CEP4
- Precursor of CEP6
- Precursor of CEP8
- Precursor of CEP7
- Precursor of CEP14
- Precursor of CEP13
Sequence:
MESFMGQKKTLYACYFLMLVFFLGFNCVHGRTLKVDDKINGGHYDSKTMMALAKHNDMMVDDKAMQFSPPPPPPPPSQSGGKDAEDFRPTTPGHSPGIGHSLSHN
Protein: Klarsicht, isoform H (X2J8G9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPQSSNSNISSSNSLLQQRNHNIGNKMLPNKAHGKNIAVAVITPNSHGNTSHGHGLGHGLGHELNKSPLGLRKTRHHHNDTSKFNRSNRKSKNCAIFYFKHLDTDNEQGNAAGSDLQSEDDPSLIHRRRAGGDILKSADASTDDDDEGWLYTATAAATLEVATAATAAPTAAAATSSVDGLQSTAVSSTTATGGPLPPSDDSDKENKVALVSATTITAAATATATSIATLHSSNYDSSSACSSSNSNSNSNSNSNGRLTETSATSRVTQLQMQIHSQSQSQSQMELQINGNAIDGRHIISNNNCYSSMQHQPQNNNEGEAAEDLAKIKMGDDEAAADMANGNATKSQQMSNGVYSRADSCNFTVWAAETVASCHLPPRSPAKSAKSSKSQASNATVSGSTLVSPVKGKVSHDSIKQLVLEAEHLVRDAQETALKTPTKQKHSIIKISSTVKKREVTMPHPIKQRVEEWLEHQPSTPQLLTRSHTHELLPSCKPDDCEASGEASETDSVPQAGAGVNGGAPNGAGSDTSEGFTDSIATCMQTSTNSYGNSTERIGGSAEPIGQPVTPLGFGSSNQSLNVKIVKRSQTRRKSERPWSVSCLSQLTTDAAQLTTARIVENSPSGLASHSISESALDSLSPGPRPRAASSSGTGSNAAKKADSKGSLRRRKARKKRISAASAGRKSDSGSELGGDLTQTLMKSCESMSSQQLQEFTNALLSIQKGAVVAPLSPKGDVSGVPSLADGEGGETQLMLPKFRVGSFTTAGLLATDTRLGALAALSNYMNEDEQQAELSTEDHHSSISETAWDNYQEKYNSENYSEGFDSDAARRLLEFGDDYRNFIDSQSDCCSSLSAANNLDSFSPPRMDSLQKHELKTLHINQDTITSTVDHARRQRALELQYERRRKTLEVRRKSCQDMDESLMASPQSDQQQQQLQVTPSLSASATALMTTPKIQSTSHQISHRAESVGRKLDFGGMSHSAQSLLRRTSESDTSTRRRRTVTADERRRSSRNLEKCIKLIPATTSSSSGSDSEDGEQEMRSLLQQSRDRLDDTRALKIRCHLLRPEDYNEIINTCRDNIRCLEAVLRGPPGTVLSNHCAGQTKVSACLRRRRRRRLGTELPGPTESGDSRQMVHMVECQCAPITRFVARVIEFVLDVGNMLEHFALYRFLAGTLRSLYELVDRPVGGRLGRFFDGLRGLF
Protein: Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) (Q8N4P3)
Organism: Homo sapiens (Human)
Function: ppGpp hydrolyzing enzyme involved in starvation response.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein bS16m
- Nucleoside diphosphate kinase 3
- Large ribosomal subunit protein bL27m
- Nucleoside diphosphate kinase 6
Sequence:
MGSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILTHEAGITDIVVLQAALLHDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERKRLQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPEGWSEHRVQEYFEWAAQVVKGLQGTNRQLEEALKHLFKQRGLTI
Protein: Tryptamine 4-monooxygenase (EC 1.14.99.59) (Cytochrome P450 monooxygenase psiH) (Psilocybin biosynthesis hydroxylase) (P0DPA7)
Organism: Psilocybe cubensis (Psychedelic mushroom) (Stropharia cubensis)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product. The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD. 4-hydroxy-L-tryptophan is accepted as substrate by psiD as well. The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine. The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin. The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin.
Interaction partners:
Sequence:
MIAVLFSFVIAGCIYYIVSRRVRRSRLPPGPPGIPIPFIGNMFDMPEESPWLTFLQWGRDYNTDILYVDAGGTEMVILNTLETITDLLEKRGSIYSGRLESTMVNELMGWEFDLGFITYGDRWREERRMFAKEFSEKGIKQFRHAQVKAAHQLVQQLTKTPDRWAQHIRHQIAAMSLDIGYGIDLAEDDPWLEATHLANEGLAIASVPGKFWVDSFPSLKYLPAWFPGAVFKRKAKVWREAADHMVDMPYETMRKLAPQGLTRPSYASARLQAMDLNGDLEHQEHVIKNTAAEVNVGGGDTTVSAMSAFILAMVKYPEVQRKVQAELDALTNNGQIPDYDEEDDSLPYLTACIKELFRWNQIAPLAIPHKLMKDDVYRGYLIPKNTLVFANTWAVLNDPEVYPDPSVFRPERYLGPDGKPDNTVRDPRKAAFGYGRRNCPGIHLAQSTVWIAGATLLSAFNIERPVDQNGKPIDIPADFTTGFFRHPVPFQCRFVPRTEQVSQSVSGP