wanglab/gogpt-training-data huggingface dataset:
Protein: C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JIP-1-related protein) (JRP) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) (Q9R237)
Organism: Rattus norvegicus (Rat)
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus. Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus.
Interaction partners:
- Mitogen-activated protein kinase 8
- Dual specificity mitogen-activated protein kinase kinase 7
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 9
- C-Jun-amino-terminal kinase-interacting protein 2
- Kinesin light chain 1
- Mitogen-activated protein kinase kinase kinase 11
- Mitogen-activated protein kinase kinase kinase kinase
- Amyloid-beta precursor protein
- C-Jun-amino-terminal kinase-interacting protein 3
Sequence:
MAERESGLSGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAASDTPGAEDDEEDDDELAAQRPGVGPSKAESGQEPASRSQGQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRTAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFLPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPEQAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADEAQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
Protein: Transcription factor bHLH130 (Basic helix-loop-helix protein 130) (AtbHLH130) (bHLH 130) (Transcription factor EN 69) (bHLH transcription factor bHLH130) (Q66GR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH93
- Kinesin-like protein KIN-14E
- Transcription factor GLABRA 3
- Transcription factor bHLH112
- Transcription factor bHLH111
Sequence:
MDSNNHLYDPNPTGSGLLRFRSAPSSVLAAFVDDDKIGFDSDRLLSRFVTSNGVNGDLGSPKFEDKSPVSLTNTSVSYAATLPPPPQLEPSSFLGLPPHYPRQSKGIMNSVGLDQFLGINNHHTKPVESNLLRQSSSPAGMFTNLSDQNGYGSMRNLMNYEEDEESPSNSNGLRRHCSLSSRPPSSLGMLSQIPEIAPETNFPYSHWNDPSSFIDNLSSLKREAEDDGKLFLGAQNGESGNRMQLLSHHLSLPKSSSTASDMVSVDKYLQLQDSVPCKIRAKRGCATHPRSIAERVRRTRISERMRKLQELVPNMDKQTNTSDMLDLAVDYIKDLQRQYKILNDNRANCKCMNKEKKSI
Protein: GTP binding protein-like (GTP-binding protein, HflX) (Q9FJM0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GTPase Der
- Large ribosomal subunit protein bL28c
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL27c
- Large ribosomal subunit protein bL21c
- AT5g15220/F8M21_110
- Large ribosomal subunit protein bL21m
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL9c
- Large ribosomal subunit protein bL20c
Sequence:
MSSFYLSSSPIFKLQWHANHKPKPNRAIVSFPPSRLHANCYSWRLSCNLAQHGIELEETVEEDEILQVLDLPTEETNLDNETIASPSKMLRKKKGDEESLDDRFKLRNGKEIFEEKAYLVGVERKGDGECLFNIEESLEELEQLADTAGLAVVGSTYQKLASPNPRTYIGSGKVAEIKSAINALDVETVIFDDELSPGQLRNLEKAFGGDVRVCDRTALILDIFNQRAATHEAALQVALAQMEYQLPRLTRMWTHLERQSGGQVKGMGEKQIEVDKRILRTQIGVLKKELESVRKHRKQYRSRRVAIPVPVVSLVGYTNAGKSTLLNQLTGANVLAENRLFATLDPTTRRVQMQNGKEFLLTDTVGFIQKLPTTLVAAFRATLEEIAESSLLVHVVDISHPLAEQQIEAVEKVMSELDVSSIPKLVVWNKVDRVDDPQKVKLEAEETGDTICISALTGEGLDDFCNAVHEKLKDSMVWVEALLPFDKGDLLSTIHKVGMVKETEYTENGTLIRAHVPLRFAQLLKPMRHLVKDTSISQRG
Protein: DNA-binding protein VF_0530 (Q5E7H1)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Function: Binds double-stranded DNA (dsDNA).
Interaction partners:
Sequence:
MALIMTQQNNPLHGITLQKLLTELVEHYGWEELSYMVNINCFKKDPSIKSSLKFLRKTDWARERVENIYLKLQRHKERNQ
Protein: Probable beta-D-xylosidase 6 (AtBXL6) (EC 3.2.1.-) (Q9LXA8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Uncharacterized protein At2g41810
- Putative serine carboxypeptidase-like 30
- F8A5.27 protein
Sequence:
MNLQLTLISLLFFTSAIAETFKNLDSHPQFPCKPPHFSSYPFCNVSLSIKQRAISLVSLLMLPEKIGQLSNTAASVPRLGIPPYEWWSESLHGLADNGPGVSFNGSISAATSFPQVIVSAASFNRTLWYEIGSAVAVEGRAMYNGGQAGLTFWAPNINVFRDPRWGRGQETPGEDPKVVSEYGVEFVRGFQEKKKRKVLKRRFSDDVDDDRHDDDADGKLMLSACCKHFTAYDLEKWGNFTRYDFNAVVTEQDMEDTYQPPFETCIRDGKASCLMCSYNAVNGVPACAQGDLLQKARVEWGFEGYITSDCDAVATIFAYQGYTKSPEEAVADAIKAGVDINCGTYMLRHTQSAIEQGKVSEELVDRALLNLFAVQLRLGLFDGDPRRGQYGKLGSNDICSSDHRKLALEATRQGIVLLKNDHKLLPLNKNHVSSLAIVGPMANNISNMGGTYTGKPCQRKTLFTELLEYVKKTSYASGCSDVSCDSDTGFGEAVAIAKGADFVIVVAGLDLSQETEDKDRVSLSLPGKQKDLVSHVAAVSKKPVILVLTGGGPVDVTFAKNDPRIGSIIWIGYPGETGGQALAEIIFGDFNPGGRLPTTWYPESFTDVAMSDMHMRANSSRGYPGRTYRFYTGPQVYSFGTGLSYTKFEYKILSAPIRLSLSELLPQQSSHKKQLQHGEELRYLQLDDVIVNSCESLRFNVRVHVSNTGEIDGSHVVMLFSKMPPVLSGVPEKQLIGYDRVHVRSNEMMETVFVIDPCKQLSVANDVGKRVIPLGSHVLFLGDLQHSLSVEF
Protein: Cellular tumor antigen p53 (Tumor suppressor p53) (P25035)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MADLAENVSLPLSQESFEDLWKMNLNLVAVQPPETESWVGYDNFMMEAPLQVEFDPSLFEVSATEPAPQPSISTLDTGSPPTSTVPTTSDYPGALGFQLRFLQSSTAKSVTCTYSPDLNKLFCQLAKTCPVQIVVDHPPPPGAVVRALAIYKKLSDVADVVRRCPHHQSTSENNEGPAPRGHLVRVEGNQRSEYMEDGNTLRHSVLVPYEPPQVGSECTTVLYNFMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRKTEEINLKKQQETTLETKTKPAQGIKRAMKEASLPAPQPGASKKTKSSPAVSDDEIYTLQIRGKEKYEMLKKFNDSLELSELVPVADADKYRQKCLTKRVAKRDFGVGPKKRKKLLVKEEKSDSD
Protein: Protein POOR HOMOLOGOUS SYNAPSIS 1 (Q45GQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for accurate chromosome segregation in meiosis. Required for pairing to occur between homologous chromosomes. Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks. Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus. May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19918061}. Note=Localizes to the cytoplasm during leptotene, zygotene and pachytene. {ECO:0000269|PubMed:19918061}.
Interaction partners:
- RNA polymerase II C-terminal domain phosphatase-like 4
- Protein PARTING DANCERS
- Dual specificity protein phosphatase PHS1
- Protein gamma response 1
- Meiosis-specific protein ASY1
- DNA repair protein RAD51 homolog 1
- Protein MULTIPOLAR SPINDLE 1
- Protein PUTATIVE RECOMBINATION INITIATION DEFECT 1
- Type 2 DNA topoisomerase 6 subunit B-like
- Protein DOUBLE-STRAND BREAK FORMATION
Sequence:
MAGSLTASNRRRNAEDSSEIYRWTIGFARFVHYPSSPSPHPVLKPLGKREQYHSPHGTWLSASSSTVSLHIVDELNRSDVILSVKLGQKVLEEHYISKLNFTWPQMSCVSGFPSRGSRAIFVTYMDSANQIQKFALRFSTCDAALEFVEALKEKIKGLKEASTQNQKNKTRCDVSFQSDYNPSDAIIPRATQKEPNMVRPLNSYVPEMLPRIVYEAQYQKSETRSEVSFQSDYNPSIEIFPRATEEEPNMVRFFDSSVPEVLPRPEYEAGQALYPSQSTLNQIPSLPPSFTTLLSGCFPDSTLDAGQTTVKQNPDLKSQILKYMEDSSFQDMLQKVERIIDEIGGNWIT
Protein: Probable WRKY transcription factor 7 (WRKY DNA-binding protein 7) (Q9STX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable pectate lyase 13
- Hydroxyproline-rich glycoprotein family protein
- LRR receptor-like serine/threonine-protein kinase FEI 2
Sequence:
MTVELMMSSYSGGGGGGDGFPAIAAAAKMEDTALREAASAGIHGVEEFLKLIGQSQQPTEKSQTEITAVTDVAVNSFKKVISLLGRSRTGHARFRRAPASTQTPFKQTPVVEEEVEVEEKKPETSSVLTKQKTEQYHGGGSAFRVYCPTPIHRRPPLSHNNNNNQNQTKNGSSSSSPPMLANGAPSTINFAPSPPVSATNSFMSSHRCDTDSTHMSSGFEFTNPSQLSGSRGKPPLSSASLKRRCNSSPSSRCHCSKKRKSRVKRVIRVPAVSSKMADIPSDEFSWRKYGQKPIKGSPHPRGYYKCSSVRGCPARKHVERALDDAMMLIVTYEGDHNHALVLETTTMNHDKTL
Protein: Tight junction protein 2 (A0A8I6GLX8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MPVRGDRGFPLRRELSGWQRGPGMEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSRHSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRDYDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLRSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFKPEPPKVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL
Protein: Rab GDP dissociation inhibitor (Q9VLB7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU363124}.
Interaction partners:
- Ras-related protein Rab6
- Rab11
- Ras-related protein Rab7
- FI01544p
- Ras-related protein Rab5
- LD44762p
- LD39986p
- CG2885
- LD21953p
- Ras-related protein Rab-3
Sequence:
MNEEYDAIVLGTGLKECILSGMLSVSGKKVLHIDRNKYYGGESASITPLEELFQRYGLEPPGERFGRGRDWNVDLIPKFLMANGQLVKLLIHTGVTRYLEFKSIEGSYVYKGGKIAKVPVDQKEALASDLMGMFEKRRFRNFLIYVQDFREDDPKTWKDFDPTKANMQGLYDKFGLDKNTQDFTGHALALFRDDEYLNEPAVNTIRRIKLYSDSLARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDKPIDEIVLGEGGKVVGVRSGEEVAKCKQVYCDPSYVPEKVRKRGKVIRCICILDHPVASTKDGLSTQIIIPQKQVGRKSDIYVSLVSSTHQVAAKGWFVGMVSTTVETENPEVEIKPGLDLLEPIAQKFVTISDYLEPIDDGSESQIFISESYDATTHFETTCLDVLNIFKRGTGETFDFSKIKHELGDEEQ
Protein: Uncharacterized protein (Q57XV6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RNase III domain-containing protein
- Argonaute-like protein
Sequence:
MIFGEDIGPQDSVAVSCGSTNMVNDTPKEALVLQRRGRWVMKLAVALFLSGKDLQSEGELSIMHSEIWSYAALGNEAVRRGYVPLGTPVAGAQSVWKRKLGELWLEKGFEPCMIQLEPYFQQEFERLLAKGILKPQSGTEKDSNCSAVRPVDTPEPARLSSRNNGAVEEFAKPLASLYEASLRYLRNVGMKTTASTNGWVSAEELYSYLKDRKHSLIVKVPDDIVSECDVLPTTPARLLVVLSQLDLIGRLQFRWERSSKVDGKRDGERMSLGDEQVECSVSVRAAWAHKDSSLASKVVSDHPKMALEKALEIFSPCREIYDFVESVERWEVAAKLHGREIPTFRPFLMLAVGDSIRARIPKDPVRRAAALLASKVTTKSAFLSVSRSFLGLHLQRPVCVVHSNIFEGGAMHLRQTAGHGQPPRGVLLLHLSDIVYNAISNVDTKRGALFVKSEILYCGDASSVRSESIKSLCLETEEPKTCTEPPSTSALLFARLAEKSITFNVPAESPRVSSPTLANRILTLKRPTPTTNATEFLCGLRSLSHGMGNFAREAFFKKWIEDILALLRARNNRNGSDRSNSCRTPTEKVLSITPDCVYTDFSLIIAGKQKKDNSRPPGLRSLSKELINGIAEGGCDPLYIKSKQEGTIVVYFQSTVSDERDVTEIFFSSPLLLLRSSYTVGDNEGKQTEEETSVANHRSALFLRVDKSSDSFAEGDTFRSLTVVELDREQKKVAEALRSDCNTEVTLRSVELCVDEWCLEVLVPLEKVVEEYIFAPIKQCLYGRGNSESPFLLLSEADQAKLEQSLMEQLLLAVTPVKNEALEYLGDAVLDFVVAQEKLNSWTGGPIVDATCNASLAKCLFPQLRNYFEMKLGISNQKRQADMVEAIFGAVAMALWVIPRRKVLESSTDTTVTGGGGGETPAAGGLLPFAALLSVTKALMDALNITTQ
Protein: Thioredoxin domain-containing protein PLP3A (Phosducin-like protein 3A) (Q6NPL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Tubulin-binding protein involved in microtubule formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18390592}. Nucleus {ECO:0000269|PubMed:18390592}.
Interaction partners:
- Patatin-like protein 3
Sequence:
MDPDAVKSTLSNLAFGNVMAAAARNYQKEVLANEKAQGSNPVNEEVDLDELMDDPELERLHADRIAALKREVEKRESFKRQGHGEYREVSEGDFLGEVTRSEKVICHFYHKEFYRCKIMDKHLKTLAPRHVDTKFIKVDAENAPFFVTKLAIKTLPCVVLFSKGVAMDRLVGFQDLGTKDDFTTNKLENVLLKKGMLSKKKKEEDDEDAEYQESIRRSVRSSENLDSDSD
Protein: Hsp90 co-chaperone Cdc37 (Cell division control protein 37) (Hsp90 chaperone protein kinase-targeting subunit) (P06101)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Involved in both the HOG and the PKC MAP kinase signaling cascade necessary for adaptation to stress conditions due to high osmolarity or cell wall perturbation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent molecular chaperone HSC82
- ATP-dependent molecular chaperone HSP82
- Hsp90 co-chaperone AHA1
- Co-chaperone protein SBA1
- Heat shock protein STI1
- Cyclin-dependent kinase 1
- Peptidyl-prolyl cis-trans isomerase CYP7
- Peptidyl-prolyl cis-trans isomerase CPR6
- Serine/threonine-protein phosphatase T
- Mitochondrial protein import protein MAS5
Sequence:
MAIDYSKWDKIELSDDSDVEVHPNVDKKSFIKWKQQSIHEQRFKRNQDIKNLETQVDMYSHLNKRVDRILSNLPESSLTDLPAVTKFLNANFDKMEKSKGENVDPEIATYNEMVEDLFEQLAKDLDKEGKDSKSPSLIRDAILKHRAKIDSVTVEAKKKLDELYKEKNAHISSEDIHTGFDSSFMNKQKGGAKPLEATPSEALSSAAESNILNKLAKSSVPQTFIDFKDDPMKLAKETEEFGKISINEYSKSQKFLLEHLPIISEQQKDALMMKAFEYQLHGDDKMTLQVIHQSELMAYIKEIYDMKKIPYLNPMELSNVINMFFEKVIFNKDKPMGKESFLRSVQEKFLHIQKRSKILQQEEMDESNAEGVETIQLKSLDDSTELEVNLPDFNSKDPEEMKKVKVFKTLIPEKMQEAIMTKNLDNINKVFEDIPIEEAEKLLEVFNDIDIIGIKAILENEKDFQSLKDQYEQDHEDATMENLSLNDRDGGGDNHEEVKHTADTVD
Protein: Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) (Q5ZIH3)
Organism: Gallus gallus (Chicken)
Function: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (Probable). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6NXT4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter ZIP9
- Zinc transporter ZIP13
- Solute carrier family 30 member 9.
- Solute carrier family 39 member 12.
- Solute carrier family 39 member 11.
- Solute carrier family 39 member 10.
- Solute carrier family 39 member 14.
- Solute carrier family 39 member 6.
Sequence:
MGTIHLFRKSQRSLVGKLTHEFRLVAADRRSWKILLFGAINLICIGFLLMWCSSTNSIALTAYTYLTIFDLFSLITCLISYWVMVKKPSPVYSFGFERFEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALFFNLFTMLSVRNKPFAYVSEAASTSWLQEHVADLSRSICGIIPGLSSIFLPRMNPFVLIDIAGALALCITYMLIEINNYYAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVFGQLDKLLREVSTLDGVLEVRNEHFWTLGFGTLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPTLSSVPIANNMLNLSDHHVITMPSLKAADNLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGLGLNHGSTPYSSVLNQGFGIPGMGATQGFRTGFTNVPSRYGTNTRGQSRP
Protein: Candida glabrata strain CBS138 chromosome J complete sequence (Q6FNP2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Large ribosomal subunit protein uL1
- Ribosomal protein L15
- Large ribosomal subunit protein uL2
- Candida glabrata strain CBS138 chromosome M complete sequence
- 60S ribosomal protein L20
- Small ribosomal subunit protein uS12
- 40S ribosomal protein S27
- Large ribosomal subunit protein eL43
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS28
Sequence:
MSTFEKVVVIDAKGHLVGRLASIVAKQLLNGQKIVVVRAEALNISGEFFRNKLKYHDFLRKATAFNKTRGPFHFRAPSRIFYKAVRGMISHKTARGKAALERLKVFEGVPPPYDKKKRVVVPEALRVLRLKPGRKYTTLAKLSTSVGWKYEDVVAKLEEKRKVRSAEYYAKKRAFNKKVTAATASAAETDAAKKLATLGY
Protein: Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) (Q8BJM5)
Organism: Mus musculus (Mouse)
Function: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (Probable). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11997387}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A5
- Proton-coupled zinc antiporter SLC30A1
- Probable proton-coupled zinc antiporter SLC30A4
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Proton-coupled zinc antiporter SLC30A2
- Probable proton-coupled zinc antiporter SLC30A3
- Zinc transporter SLC39A7
- Zinc transporter ZIP11
- Zinc transporter ZIP9
- Zinc transporter ZIP1
Sequence:
MGTIHLFRKPQRSFFGKLLQEFRLVAADRRSWKILLFGAINVLCTGFLLMWCSSTNSIALTAYTYLTIFDLFSLITCLISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGLIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVSNRLCTLVSTLTVQIFKDDWIRPALSSGPVAPNVLNFSDHHVIPMPLLKNVDERTPVTSTPAKPSSPPPEFSFNTPGKNVSPVILLNTQTRPYSLGLNRGHTPYSSVFSQGLAFPGVGAGQGLRPTFPHIPSRYGINRMGQPRP
Protein: 14-3-3 protein zeta/delta (Mitochondrial import stimulation factor S1 subunit) (Protein kinase C inhibitor protein 1) (KCIP-1) (P63102)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (By similarity). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (By similarity). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P63104}. Melanosome {ECO:0000250|UniProtKB:P63104}. Note=Located to stage I to stage IV melanosomes. {ECO:0000250|UniProtKB:P63104}.
Interaction partners:
- 14-3-3 protein epsilon
- M-phase inducer phosphatase
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase A-Raf
- 14-3-3 protein beta/alpha
- Forkhead box O3
- M-phase inducer phosphatase 2
- Bcl2-associated agonist of cell death
- 14-3-3 protein theta
- ADAM metallopeptidase domain 22
Sequence:
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Protein: MaoC family protein (L7N5I2)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTQPSGLKNLLRAAAGALPVVPRTDQLPNRTVTVEELPIDPANVAAYAAVTGLRYGNQVPLTYPFALTFPSVMSLVTGFDFPFAAMGAIHTENHITQYRPIAVTDAVGVRVRAENLREHRRGLLVDLVTNVSVGNDVAWHQVTTFLHQQRTSLSGEPKPPPQKKPKLPPPAAVLRITPAKIRRYAAVGGDHNPIHTNPIAAKLFGFPTVIAHGMFTAAAVLANIEARFPDAVRYSVRFAKPVLLPATAGLYVAEGDGGWDLTLRNMAKGYPHLTATVRGL
Protein: Nuclear matrix constituent protein 1 (AcNMCP1) (I0J0E7)
Organism: Allium cepa (Onion)
Function: Architectural component of nuclear structure that plays different roles in controlling nuclear size and morphology (By similarity). Involved in the organization of multimeric complexes in the peripheral nucleoskeleton (Probable).
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:23378381}. Nucleus lamina {ECO:0000269|PubMed:23378381}. Note=Localizes at the nuclear periphery and is associated to the nucleoskeleton. {ECO:0000269|PubMed:23378381}.
Interaction partners:
Sequence:
MLTPQRSAWSLKSKVSSEKPRSKGKGITKNLDSAATPFPPLGLLNGGDLDRGGEDMEAWKRFKDEGLLDESICYKKDRESLASRIIELEKDLHEYQYNMGLLLIEKKEWSSHFEEMKMRLAEAEEILKREQAAHIIALTESEKREDNLRKALGVEKQCVTDLEKALREMRSEIAEVKYTAEKKMTEAFALEASIEEKRLDTERKLHSADAKLAEASRKSSEINRKLEDVEDRERKVQRELNSINSERKALEKDISEQKEHLREWEKKLQDGQNRLLDGQRHINEREERINEAEGGLKKKEEELEEAKRSIEGTRNTLKRKEEDLDVRLRSLVSKEKEIELKMKNLQKKEKDLHEIAEKLDHREREEIQKLLDEHRATLDTKKREFELELESKRKSVDEELKSKFAAVNKAEKEVNRKQGLISEGEKELESKMDKIKIKEKDLETKSKALKKWEESLKSDEKKLVAEKDQIMKDTHELKVSINELESLRDALNAEQHQIAEEREKLEISKEEREQYIQKQSELKQEIEKYRNMQEELSKGIESLREEREKFEKEWESLDEKKITLQRETKKIHEEKEKLEKWHHKDQERLRNEEANAKADIERQLEDIKLQKEAFENTMKHERLMAQEEVARRLADVTRELELRKHDLEMNMQKKQEEIERKLQGKEREFETRKEAELSRITSLINLNNSKLQKLRIEQDRLDREKEEVELQKKKLQEDQSEIQRDVDTLRQLSKNLKNQRAEFIKEKECFLAAAERCKTCQNCGVSISELEMVGIIQSSAEIENADIVLPSLTDDHIEQHMKNKGSHVTSPQTGSRVFGSGFLQKCTKIFKFSPGKNAETSATTTPLVFGEELDIAASEDAAANDNNPAADVERVTVNPSLVFGEQLDTAASEDAAANDNNPAADVERVTVNPPPLAPVATEQNETEESSLPPENDSPPKQRGGRQSTRRGRGGKTVRRTRTMEAVVDDAKAILGDTLIVEEAKESSQQNDEQSQGASVHTGGTSNTRQKRRRAPASEMTNSEHDVEESESQSQSISIGRGRRKKRQTSAASEVQAPVVERRYNLRHSTVAKNSVAATLAVSDQAKVQTKASHQASHDNNQISMGDDPALEGSHKVTHTVQKTTTASVMEVSSKPAMEETHEENIVVRSVEISEMSASEEAEGEVQGVPPIAEEPATPSSGSSTSGDIGNDDDMDDDDEEERHNASIGKKLWNFFTT