wanglab/gogpt-training-data huggingface dataset:
Protein: MIA SH3 domain ER export factor 2 (G3V599)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MAKFGVHRILLLAISLTKCLESTKLLADLKKCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFGYFPRDAVQIEEVFISEEIQMSTKESDFLCLLGVSYTFDNEDSELNGDYGENIYPYEEDKDEKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVVVESMEQDRIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESVIEPVQESSFRSRKIAVEDENDLEELNNGEPQTEHQQESESEIDSVPKTQSELASESEHIPKPQSTGWFGGGFTSYLGFGDEDTGLELIAEESNPPLQDFPNSISSDKEATVPCTEILTEKKDTITNDSLSLKPSWFDFGFAILGFAYAKEDKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQEIETIKIIETEDQIDKKPVSEKTDESDTIPYLKKFLYNFDNPWNFQNIPKETELPFPKQILDQNNVIENEETGEFSIDNYPTDNTKVMIFKSSYSLSEDASEFQILKYLFQIDVYDFMNSAFSPIVILTERVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
Protein: Large ribosomal subunit protein eL38 (60S ribosomal protein L38) (Q9W5N2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein uL16
- Ribosomal protein S30, isoform A
- 40S ribosomal protein S15
- Large ribosomal subunit protein eL30
- IP17351p
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL13
Sequence:
MPREIKEVKDFLNKARRSDARAVKIKKNPTNTKFKIRCSRFLYTLVVQDKEKADKIKQSLPPGLQVKEVK
Protein: Ent-pimara-9(11),15-diene synthase (PMD synthase) (EC 4.2.3.31) (Q5KSN4)
Organism: Streptomyces sp. (strain KO-3988)
Function: Involved in viguiepinol biosynthesis. Catalyzes the conversion of copalyl diphosphate (ent-CDP) into pimara-9(11),15-diene (PMD).
Interaction partners:
Sequence:
MRARHRVALKVLADLRSWAAEYPQVLEATPIEALAISTAAISPWRGANELRLSAPDVRCGPTPLDDHVEQNVRSLDELDDLFGRCEAIVRGGDRDDGHPLLASLSGWQSALERAPHYPKLAGLWGDRFAEALRGERYDWTAGLARDRGEGPSDPQEYLTYAASSNAWITHFPRWATSDRDDLLDGLPVLDNALEAIEVAVRLSNDLATFERERAEPGQNNILMYDTSPDWVHDELDRHSRKAQEQLDPLATAGFPPAVELLRLLDWSVTFYSGADFRGWGSDRDLTGPSGLPSDM
Protein: Transcription factor SCREAM2 (Basic helix-loop-helix protein 33) (AtbHLH33) (bHLH 33) (Transcription factor EN 44) (bHLH transcription factor bHLH033) (Q9LPW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA. Functions as a dimer with SPCH during stomatal initiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:18641265}.
Interaction partners:
- Transcription factor MUTE
- Transcription factor SPEECHLESS
- Transcription factor FAMA
- Protein EPIDERMAL PATTERNING FACTOR 2
- Protein EPIDERMAL PATTERNING FACTOR 1
- EPIDERMAL PATTERNING FACTOR-like protein 9
- Transcription factor MYB10
- LRR receptor-like serine/threonine-protein kinase ERL1
- LRR receptor-like serine/threonine-protein kinase ERL2
- Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
Sequence:
MNSDGVWLDGSGESPEVNNGEAASWVRNPDEDWFNNPPPPQHTNQNDFRFNGGFPLNPSENLLLLLQQSIDSSSSSSPLLHPFTLDAASQQQQQQQQQQEQSFLATKACIVSLLNVPTINNNTFDDFGFDSGFLGQQFHGNHQSPNSMNFTGLNHSVPDFLPAPENSSGSCGLSPLFSNRAKVLKPLQVMASSGSQPTLFQKRAAMRQSSSSKMCNSESSSEMRKSSYEREIDDTSTGIIDISGLNYESDDHNTNNNKGKKKGMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHTELESTPPSSSSLHPLTPTPQTLSYRVKEELCPSSSLPSPKGQQPRVEVRLREGKAVNIHMFCGRRPGLLLSTMRALDNLGLDVQQAVISCFNGFALDVFRAEQCQEDHDVLPEQIKAVLLDTAGYAGLV
Protein: Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) (P33151)
Organism: Homo sapiens (Human)
Function: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21183689, ECO:0000269|PubMed:27338829}. Cell membrane {ECO:0000269|PubMed:15980433, ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Cytoplasm {ECO:0000250|UniProtKB:P55284}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000269|PubMed:20332120}.
Interaction partners:
- Platelet endothelial cell adhesion molecule
- Vascular endothelial growth factor receptor 2
- Catenin delta-1
- Catenin beta-1
- Tight junction protein 1
- Claudin-5
- Cadherin-1
- Receptor-type tyrosine-protein phosphatase beta
- Occludin
- E-selectin
Sequence:
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY
Protein: Melanoma-associated antigen 8 (Cancer/testis antigen 1.8) (CT1.8) (MAGE-8 antigen) (P43361)
Organism: Homo sapiens (Human)
Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
Interaction partners:
Sequence:
MLLGQKSQRYKAEEGLQAQGEAPGLMDVQIPTAEEQKAASSSSTLIMGTLEEVTDSGSPSPPQSPEGASSSLTVTDSTLWSQSDEGSSSNEEEGPSTSPDPAHLESLFREALDEKVAELVRFLLRKYQIKEPVTKAEMLESVIKNYKNHFPDIFSKASECMQVIFGIDVKEVDPAGHSYILVTCLGLSYDGLLGDDQSTPKTGLLIIVLGMILMEGSRAPEEAIWEALSVMGLYDGREHSVYWKLRKLLTQEWVQENYLEYRQAPGSDPVRYEFLWGPRALAETSYVKVLEHVVRVNARVRISYPSLHEEALGEEKGV
Protein: Rabphilin-3A (Exophilin-1) (P47709)
Organism: Rattus norvegicus (Rat)
Function: Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:8060298, ECO:0000269|PubMed:8617225}. Cell projection, dendritic spine {ECO:0000269|PubMed:26679993}. Postsynaptic cell membrane {ECO:0000269|PubMed:26679993}. Membrane {ECO:0000269|PubMed:17166855}; Peripheral membrane protein {ECO:0000269|PubMed:17166855}.
Interaction partners:
- Ras-related protein Rab-3A
- Ras-related protein Rab-27A
- Glutamate receptor ionotropic, NMDA 2A
- Multifunctional fusion protein
- Syntaxin-1A
- Ras-related protein Rab-8A
- Ras-related protein Rab-27B
Sequence:
MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQEELTDEEKEIINRVIARAEKMETMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRAPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTTTRDSEGWDHGHGGGAGDTSRSPGGEQGLRRANSVQASRPAPASMPSPAPPQPVQPGPPGGSRAAPGPGRFPEQSTEAPPSDPGYPGAVAPAREERTGPTGGFQAAPHTAGPYSQAAPARQPPPAEEEEEEANSYDSDQATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD
Protein: Pyruvate kinase (EC 2.7.1.40) (Q388I8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal protein L5, putative
- Large ribosomal subunit protein uL5
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L19, putative
- Large ribosomal subunit protein eL18
- 60S ribosomal subunit protein L31, putative
- Enolase, putative
- Glucose-6-phosphate isomerase
- 40S ribosomal protein S15a, putative
Sequence:
MTLRVVSKEDDRTLKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFGVAQGVDMIFASFIRTAEQVREVRAALGEKGKDILIISKIENHQGVQNIDSIIEASNGIMVARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTRAEVSDVANAVLNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQKIPMCPEEAVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICVTTRLQTCRQLNVTRSVVSVFYDAAKSGEDKDKEKRVKLGLDFAKKEKYASTGDVVVVVHADHSVKGYPNQTRLIYLP
Protein: Haemophore haem-binding domain-containing protein (O53654)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAASEVARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLKAHFEANPKVASDLHALSQPLTDLSTRCSLPISGLQAIGLMQAVQGARR
Protein: Transcription factor (bHLH transcription factor) (Basic helix-loop-helix protein) (Q69IU0)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369104}.
Interaction partners:
Sequence:
MDELLSPCSSFSPPSPSSMFSTGAAAAAAHAVLEFTSCEVPDEWLMGDVVMAKNEEDVGGGELWPVFAGGSLSPDSELSELPRSFEAAAAQRPAKRRGRKPGPRPDGPTVSHVEAERQRREKLNRRFCDLRAAVPTVSRMDKASLLADAAAYIAELRARVARLESDARQAAAARFEPSSCGGGGNASYHGGGGGGGAAPGLDEAVEVRKMGRDAAAVRVTTTGARHAPARLMGALRSLELPVQHACVMRVHGATTVQEVLVDVPAALQDGDALRAALLQRLQDS
Protein: Uncharacterized transporter C569.05c (Q9Y7S4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein SPCC1884.01
- Probable L-asparaginase 2
Sequence:
MSTNPNAGIQPLTNSISQSASAHPELYHTTSHESVSTYQLQSQLSHSATSNLSTAANFHTRPPIANDENAQNLSTVNSSHSSELSKANLVDVEKCIQDPLLQIFPTVEDPDRFVFSIDPKSPLIAVNWPFRKKLKITCVYSYVALCSTFASSVFSVPAEAITTIFHISLTVSLLTMTVFLCGYIAGPIVWAPLSELSGRKLPLLIGMFGFGIFNISVAVAKDIQTIMMCRFFSGFFASAPLTVVAAAFADMYSNKHRGTAITIFAALVFDGPLVSPIIGGFLTKSYLGWRWTEYITSFMGFFALVIVYLFCDETYSKAIIRNKAKEYRAMSGNYFVHAKSEEEVLTVPDVAKNYLLVPMKLLFTEPIVFLITLYSSFVYAILYLLLEAYPIIFSEKRHFSMGVAELPYIGLLVGVFIGSAINISFEPWYYRRCLALGGKPDPEARLPPMMIGCFMFPAGIFWLSWSGYYSYVHWIVPTLSGLATGCGILLIFLQCLNYLIDAYLFRAASAVAANTIMRSAMAAGFPLFAVQMFHNMGVGWAGSLLGFIAVALIPMPFAFFFFGRKIREKSKMAVVL
Protein: Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] (P0ACC7)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949}.
Interaction partners:
- Phosphoglucosamine mutase
- Glutamine--fructose-6-phosphate aminotransferase
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- Ribose-phosphate pyrophosphokinase
- UDP-N-acetylglucosamine 2-epimerase
- UDP-N-acetylmuramate--L-alanine ligase
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Phosphate acetyltransferase
- ATP synthase subunit c
Sequence:
MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
Protein: Esterase P (Est-P) (EC 3.1.1.1) (Carboxylic-ester hydrolase P) (Carboxylesterase-P) (P18167)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted.
Interaction partners:
- GH07829p
- Esterase-6
- Beta-glucuronidase
- Beta-glucuronidase
- Cytidine deaminase
- cytidine deaminase
- Cytidine deaminase
Sequence:
MSIFKRLLCLTLLWIAALESEADPLIVEITNGKIRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQVLRISRNACKNEEYARFP
Protein: Serum resistance associated protein (Q70MW9)
Organism: Trypanosoma brucei rhodesiense
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MPRNSGRTTSTLALALALKLLAVPVSPSGTAFDEEPVKKVCKVEKNLADVAGIALAKINNLIKQVSAATEAEARMTLAAASTDHSNISALYAAASNIVTRCVLNAVHALTSLAPIALTAATNGAKTSGHISEVIDILQQASQGKTEGKCIVKSGGGTTTV
Protein: Cell division control protein 6 homolog B (AtCDC6b) (Q8W032)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the initiation of DNA replication.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O82387}.
Interaction partners:
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- CDT1-like protein b
- CDT1-like protein a, chloroplastic
- Origin of replication complex subunit 2
- Origin of replication complex subunit 5
- DNA replication licensing factor MCM7
- Origin of replication complex subunit 6
- DNA replication licensing factor MCM6
Sequence:
MPTNAGTSLSSYKHIVAIGTTVKSESLESAAYEIPRKRKMRSDSAAVSGNSVSTPKKLKSHLPSSVPNPGMSEKEVVEDSNEILRYPVNLAVSDCLGTKSKWSPRDEEQMRAVKEALHVSKAPSTILCREDEQIRIFEFVKGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSTQAGLPPVDTLSVNCTSLSKTTDIFSKILGEIKPGKNANTNSSPLQHLQNLFSQKQESSSSRMMLIIADEMDYLITKDRGVLYDLFMLTTLPFSRCILIGVANAIDLADRFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRVLSYVAFQPKALELCARKVAAASGDMRKALCVCRSALEILEIETRGSTGPESQGPTPDDSVVRMDHMAAALSKTFKSPVVETIQSLPQHQQIIICAAAKAFRGSKKDATVGELNKLYLEICKSWMISPAGITEFTNMCTVLNDQGILKVGQARRDKLKRVSLRVDESDITFALQEIRFFRNCLL
Protein: Uncharacterized protein (Q384A1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Enoyl-CoA delta isomerase 1, mitochondrial
Sequence:
MLSSALRFVKPVKRMTATAGRIVFSSITNTQKRVSTSSQATTKSTLVLSDEDRKLMPQGIAQPTIAEPGGVNAQQEPRNASDTMDASTAVGIGNLRRGNSGASTHAGGYAPWEIRALLVPLLPVGNTFVHISSVIHLLPSAARKEMEREGTPLQYIEKYLSDSVIVRGSLLSRITTGASSCDKGNGCNKASVAPPPPPISVGRASGPASQQQQQQQGLPPRGGAGAKTTLEVLDMLIEFIPTFFVQHQMVADQLPSEITKQFADSSFLYYLKRFRHYIDIRASHGNTEIRLRPDFSHPKRGAADSLYTTGLSSNDILSQLARGRRPPRHSEANLIQFIVPRMPIEYTPIATVLQDVSDIVSRHPSFDPRLGVTGLFEKYPEYFQITDSKLRVRPFRSAPNSLDDLNATTSPLPAIYEKVKQLVDAQAEGKDYSKESEKAAAIVPTGKLYALLTNVEKTEVKAKCRSFPRFLRLHGEEIVVSVDSMKVYKFRPTYEPCAETLMDQRLMMSSLSPSDPVLKIPATMEESSSADWAVRELYDALPLMQCAELSEVMSLVPPSIRDALPKELEKLVEHLALYPDYFATWPYPDDPTVMVVQRAKLEPLHLKNEDIVRMVLSFIPQGGIEAHKLMRRVPLPLQRHFYRHGLKRVLGELKDYFLIVGDKVMRVG
Protein: Cyclic nucleotide phosphodiesterase inhibitor (PDI) (P22549)
Organism: Dictyostelium discoideum (Social amoeba)
Function: PDI acts by binding stoichiometrically to cyclic nucleotide phosphodiesterase, changing the KM of the enzyme for cAMP from 10 uM to 2 mM.
Interaction partners:
- Tiny macrocysts protein C
- Tiny macrocysts protein B
Sequence:
MAKIIISLILLLSLFSFSYGAYNCNKLNCSSKNTKCRTFSCTSVVGCYYTDKCTSPDLCHNSACNASTGNCTLTTISCNDNNPCTDDFCHPGYGCYSVPNSCDPGVICQQNCNDNDPCTYDFCDALNICRHSETYCNDGDACTLNTCGVNGCNFTKISCDDNDPCTADYCSTLYGCYHEPIECSIKVPCNIDSDCNRNNGCETFTCNLSTNTCDYYAKNCGGWPCINNQCTTGSISN
Protein: Regulator of nonsense transcripts 3B (UPF3B regulator of nonsense mediated mRNA decay) (Up-frameshift suppressor 3 homolog B) (F1QNX7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BZI7}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZI7}.
Interaction partners:
- Regulator of nonsense transcripts 1
- Uncharacterized protein.
- Protein mago nashi homolog
- Nonsense-mediated mRNA decay factor SMG5
- Telomerase-binding protein EST1A
- Eukaryotic initiation factor 4A-III
- SMG7 nonsense mediated mRNA decay factor.
- Protein CASC3
- RNA-binding protein 8A
- RNA-binding protein with serine-rich domain 1
Sequence:
MKEDKENTRPREKKVEIKCDENDKQEKPCKEKKEAMTKIVIRRLPPTLTKEDLEEQLQPLPELDYLEFFSSDTSLFPHLFARAYLNFKNQDDIVLFRDRFDGYVFIDNRGQEYPAIVEFAPFQKVAKKRSKKKDAKSGTIDDDADYKKFLEFYNGDEEKSPSNPEILLEEIEAKTKELSSKKTTPLLDFLKNKQRIREEKKEERRRREIERKRLREEERRKWREEDRRKRKEAEKLKKVEKAFEKDKDQHKDEQPKIKLLRKPEKADDGETEKPKDKPKKQDRERQKEDRPSGGDLKKRQNGEHREEKGGKPEDVGHKEYRDRDGERERDRDRERERRQKEKERIRRQDEERRRRREHQDGENNYRKREEEGKKDKERVWEKRKNEHTGESSGSARPEKSSRDSKKEESARKDRLRNKDRPAIQLYQPGSRNRTRGGGGGGGTGGDGPAAEKRAEREAKKNQEKAAE
Protein: Mitochondrial fission 1 protein (FIS1 homolog) (rFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) (P84817)
Organism: Rattus norvegicus (Rat)
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (By similarity). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15979461}; Single-pass membrane protein {ECO:0000269|PubMed:15979461}. Peroxisome membrane {ECO:0000269|PubMed:15979461}; Single-pass membrane protein {ECO:0000269|PubMed:15979461}.
Interaction partners:
- TBC1 domain family member 15
- B-cell receptor-associated protein
- Dynamin-1-like protein
- TBC1 domain family, member 17
- Mitofusin-2
- Mitochondrial fission factor
- Mitochondrial fission factor
- Dynamin-1
- Mitofusin-1
- E3 ubiquitin-protein ligase MARCHF5
Sequence:
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
Protein: Innexin-11 (Protein opu-11) (Q23157)
Organism: Caenorhabditis elegans
Function: Structural component of the gap junctions.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction {ECO:0000250}.
Interaction partners:
- Fucose-specific lectin
Sequence:
MVMIETFLGMAKYLSPREDDDWSDRLNYLMTPNILLAFSVLISFKQFGGRPIECMFPNKFPGSWEQYAENYCWSQDTYFVEPTQDVSLLKKEERYTPDRQLSYYQWVPFFLLLQAAFFRAPSYLWKYFSNHSGIRIHEVVEKAKDSANVEEEVREKNILILKRHLSSALRFQANMERKKVQVHKTVTFLNFQYSSGFISWIYLFTKVLYFLNVFAQLYLMNYFLGTNRHHWYGFGVVQDIVQGEPWERSGYFPRAAVCDFEVRQVANIQRYSVQCVLVINIFNEKIFVLLWFWYVILLLSSTVSLVQWFIVLVFPCFSKWFVKQHLALSTLQNFNQRNSRREDSDVSKFVTQYLHKDGVFVLRMVSSHAGIIFATDLVQALYEAYDFQDKNKDVQGSPVSDDLQTISTGAESSIRQRKTRKGSRIEYKAGFPISTSLMPDKDDIESSSTSSEEDQKRVSNVITNI
Protein: CUB and zona pellucida-like domain-containing protein 1 (CUB and ZP domain-containing protein 1) (Estrogen-regulated protein 1) (Uterus/ovary-specific protein 44) (Q9QZT0)
Organism: Rattus norvegicus (Rat)
Function: Localized to zymogen granules, where it functions in trypsinogen activation (By similarity). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
Subcellular location: Zymogen granule membrane {ECO:0000250|UniProtKB:P70412}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P70412}.
Interaction partners:
Sequence:
MEVTGRLFIWAILAVSCRAQLNSTAAEGRPRCTASLGGANLGETHKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPLLGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFSSGTTIPNCGGYLQTLEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGPSTTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYASTYVQEVNTHSLSCASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDHTISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGKYNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDHTSRCNQGCVSRRKRDIPSYKWKTDSVIGPIRLKRDRLVNGDSGLLPQTHEAEISKQPLSHLHLFSFMVLALNVVIVVTATVRHFLNRWKDHGYQKLQVY
Protein: Uncharacterized protein (Q587C4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- 30S ribosomal protein S8, putative
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Trans-sialidase
- Uncharacterized protein
Sequence:
MLRRSILFRMKYADLELTTRGEFPHGMKEPAFVKKLDQNIPWYFSTYRSMYHWPITGDNWSDLNEAEKHHDLHMFYTLAWWKLGEGIFGVDEDS
Protein: Cytochrome b6-f complex subunit 4 (17 kDa polypeptide) (P56774)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01344}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01344}.
Interaction partners:
- Cytochrome f
- Cytochrome b6-f complex subunit 5
- Cytochrome b6
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Cytochrome b6-f complex subunit 8
- Photosystem II reaction center protein H
- Photosystem II D2 protein
- Photosystem I iron-sulfur center
- NAD
- Cytochrome b559 subunit beta
Sequence:
MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAAALWLGIGATLPIDKSLTLGLF