wanglab/gogpt-training-data huggingface dataset:
Protein: Fibronectin type III domain-containing protein 1 (Activator of G-protein signaling 8) (Q2Q0I9)
Organism: Rattus norvegicus (Rat)
Function: May be an activator of G protein signaling.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MAPEARASPRLLLRAALLLLAALLPVASSAGPPVDHPLKPRHVKLLSANMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKSIKVNAETHSFLIKDVEKEVPNKPLRMRVRASDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTNSQGQSQPVYRAALTKRKNAEEDELDVPEDISVRVMSSQSVLVAWVDPLVEKQKRVVASRQYTVRYREKGESARWDYKQVSNRRALVDSLIPDTVYEFAVRISQGERDGKWSASVFQRTPESAPTTAPENLRVWPVNGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNRRGQGPHSKAFIVAIPTTSSTEASVQPNGRDNGKPEKPQQPSSSAPKVAASSQHMPPAKNVKDALSDLKNKIQTNGVAPGRTQLHSKVGELDPQSTEVTGEEELDSLENPRSSRLETLNQKQPLRVPSRSGHGALAPGRTPARAGLPVLSRKEGMDRRGPSLDPHPHPRVEPSASSAYHQLSSTDNDSVDRKEDDQAGSPDPKAASSGSSPKNPGRSRPTSAPSRHAASNMLRDKSRVHPGTKAASSSTSRQSHSSTSEEDSSAQPSRHFPLHRGSSTSPLSRGWKDRQDTHASSSHTTSRTASSSHPSALTEGSEEEDGGADSDRAAEDTIRRAEATAQIQQTRPGLGHFSLIRNKPFTPHSRNPNRFPRLRGPRLQPSVSPQSTSASKVLTRSPSLPASHTRPGSDVYGDGEDEEPLPATVINDRTPSYPRHPISGSSDTLRRGPQRGASLYRKEPIPENSKAAGADVPPGGRSPLSSKAQGFQQSTTDEGAPQTSPASTSRQPSPARPPASRSQPSPGSTVPRRMTPDRSSELSSSQSKDRSLSQPKLSVAHAGHDHPHTANSRGVLPSAPQNQNEGAQSTYEDNSTEIEGPDSRTPTHSARAKDTTPPILKPRQVGSQSWSSDNRPQPSQAGASERPIRPGSTHPRAQVPGRAGVQATSVKKVSPSKRPLPLESQQSVFAEEEEENEGMLKGKEDSLSTSVKKWPSSSSPRDKYADRNLDKDKAAIGLLVQEENTVPGRRPPGSPAIASHPSTRHQPRNPATASPIANTHSWPRYTTRAPSSYSSTTPMLSLRQRMQRRFRTPVSRQPPPPRPVLTPGYNGRPNAEENIPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRLGGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLEVVRTTTQVPTTTMPPSTTTTTVPPTTTLPPTTTTTRRTTTTRRTTTTRRPTTTTRATRRTTTTTTTPEPTTPSPTCPPGTLEHRDEAGNLIMGSNGIPECYPEEDDFSGLEIDTALPTEEDYVVYDDDYGLETTRPPTSTMPSTTAATPKVVPEQGTVSSFPEEEFDLAGKRRFVAPYVTYLSKDPAAPCSLTDALDHFQVESLDELIPNDLTKNDLPPQHAPRNITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGHIGFGTPYYYVGWYECGVSIPGKW
Protein: Aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) (P13035)
Organism: Escherichia coli (strain K12)
Function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor.
Subcellular location: Cytoplasm.
Interaction partners:
- Glycerol kinase
- Glycerol uptake facilitator protein
- Anaerobic glycerol-3-phosphate dehydrogenase subunit A
- Anaerobic glycerol-3-phosphate dehydrogenase subunit B
- Glycerol-3-phosphate dehydrogenase [NAD
- Anaerobic glycerol-3-phosphate dehydrogenase subunit C
- Glycerol-3-phosphate acyltransferase
- Probable glycerol-3-phosphate acyltransferase
- Glycerophosphodiester phosphodiesterase, periplasmic
- Uncharacterized protein AzuC
Sequence:
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARRENGLWIVEAEDIDTGKKYSWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLNVYNTHFKKQLSRDDIVWTYSGVRPLCDDESDSPQAITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYARTYGSNSELLLGNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNADQQSRVSQWLVEYTQQRLSLAS
Protein: Cytochrome P450 2C29 (EC 1.14.14.1) (Aldehyde oxygenase) (CYPIIC29) (Cytochrome P-450 MUT-2) (Q64458)
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of 14,15 double bond of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 14,15-epoxyeicosatrienoic acid (14,15-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 3A11
- Cytochrome P450 1A2
- Epoxide hydrolase 1
- Cytochrome P450 2U1
- Polyunsaturated fatty acid lipoxygenase ALOX15
- UDP-glucuronosyltransferase 2A3
- Cytochrome P450 2E1
- Bifunctional epoxide hydrolase 2
- Polyunsaturated fatty acid 5-lipoxygenase
- UDP-glucuronosyltransferase
Sequence:
MDLVVFLALTLSCLILLSLWRQSSGRGKLPPGPTPLPIIGNFLQIDVKNISQSFTNFSKAYGPVFTLYLGSKPTVILHGYEAVKEALIDRGEEFAGRGSFPMAEKIIKGFGVVFSNGNRWKEMRRFTLMTLRNLGMGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQNRFDYKDKEFLILMDKINENVKILSSPWLQVCNSFPSLIDYCPGSHHKIVKNFNYLKSYLLEKIKEHKESLDVTNPRDFIDYYLIKQKQVNHIEQSEFSLENLASTINDLFGAGTETTSTTLRYALLLLLKYPDVTAKVQEEIDRVVGRHRSPCMQDRSHMPYTDAMIHEVQRFIDLLPTSLPHAVTCDIKFRKYLIPKGTTVITSLSSVLHDSKEFPNPEMFDPGHFLNGNGNFKKSDYFMPFSTGKRICAGEGLARMELFLILTTILQNFKLKSLVHPKEIDITPVMNGFASLPPPYQLCFIPL
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB1 (TFIIH subunit XPB) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB1) (ERCC3 homolog 1) (Protein araXPB) (RAD25 homolog 1) (AtXPB1) (XPB homolog 1) (Q38861)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription (By similarity). Required during the early stages of development, including seed germination.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- General transcription factor IIH subunit 2
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit TFB2
- General transcription and DNA repair factor IIH subunit TFB4
- Cyclin-H1-1
- General transcription and DNA repair factor IIH subunit TFB1-3
- General transcription and DNA repair factor IIH subunit TFB1-1
- DNA excision repair protein ERCC-1
- Pentatricopeptide repeat-containing protein At4g30825
- DNA repair protein UVH3
Sequence:
MGNGERGRPNKKMKYGGKDDQKMKNIQNAEDYYDDADEDSRDGEGEEKKRDFTKLELKPDHGNRPLWACADGRIFLETFSPLYKQAYDFLIAIAEPVCRPESMHEYNLTPHSLYAAVSVGLETETIISVLNKLSKTKLPKEMIEFIHASTANYGKVKLVLKKNRYFIESPFPEVLKRLLSDDVINRARFSSEPYYGGDGFSVGRTCGELEAGPGELLNEAEFAAAAEEKETHSFEIDPAQVENVKQRCLPNALNYPMLEEYDFRNDNVNPDLDMELKPHAQPRPYQEKSLSKMFGNGRARSGIIVLPCGAGKSLVGVSAAARIKKSCLCLATNAVSVDQWAFQFKLWSTIRDDQICRFTSDSKERFRGNAGVVVTTYNMVAFGGKRSEESEKIIEEMRNREWGLLLMDEVHVVPAHMFRKVISITKSHCKLGLTATLVREDERITDLNFLIGPKLYEANWLDLVKGGFIANVQCAEVWCPMTKEFFAEYLKKENSKKKQALYVMNPNKFRACEFLIRFHEQQRGDKIIVFADNLFALTEYAMKLRKPMIYGATSHIERTKILEAFKTSKDVNTVFLSKVGDNSIDIPEANVIIQISSHAGSRRQEAQRLGRILRAKGKLEDRMAGGKEEYNAFFYSLVSTDTQEMYYSTKRQQFLIDQGYSFKVITSLPPPDAGSSLSYHSQEEQLSLLGKVMNAGDDLVGLEQLEEDTDGMALQKARRSMGSMSVMSGSKGMVYMEYNSGRHKSGQQFKKPKDPTKRHNLFKKRYV
Protein: P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) (P41231)
Organism: Homo sapiens (Human)
Function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Ectonucleoside triphosphate diphosphohydrolase 1
- P2X purinoceptor 1
- P2X purinoceptor 4
- P2X purinoceptor 2
- P2X purinoceptor 5
- P2Y purinoceptor 6
- P2X purinoceptor 3
- Proto-oncogene tyrosine-protein kinase Src
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Sequence:
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
Protein: At3g17830 (Molecular chaperone Hsp40/DnaJ family protein) (Q058J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock protein 70
- Chaperone DnaJ-domain superfamily protein
- Heat shock protein DnaJ with tetratricopeptide repeat-containing protein
- Heat shock protein DnaJ with tetratricopeptide repeat-containing protein
- Heat shock 70 kDa protein 7, chloroplastic
- Heat shock 70 kDa protein 6, chloroplastic
- Chaperone DnaJ-domain superfamily protein
- Similar to part of disease resistance protein domain family protein)
- Heat shock protein 90-1
- Major latex protein-like
Sequence:
MAAMARCALIPSINPAHSFRHQFPQPNASFYLPPTLPIFSRVRRFGISGGYRRRVITMAAGTDHYSTLNVNRNATLQEIKSSYRKLARKYHPDMNKNPGAEDKFKQISAAYEVLSDEEKRSAYDRFGEAGLEGDFNGSQDTSPGVDPFDLYSAFFGGSDGFFGGMGESGGMGFDFMNKRSLDLDIRYDLRLSFEEAVFGVKREIEVSYLETCDGCGGTGAKSSNSIKQCSSCDGKGRVMNSQRTPFGIMSQVSTCSKCGGEGKTITDKCRKCIGNGRLRARKKMDVVVPPGVSDRATMRIQGEGNMDKRSGRAGDLFIVLQVDEKRGIRREGLNLYSNINIDFTDAILGATTKVETVEGSMDLRIPPGTQPGDTVKLPRKGVPDTDRPSIRGDHCFVVKISIPKKLSERERKLVEEFSSLRRSSSSTGPTETRQEEQSFGSEPRKEPSLWHKMKNFIRPEDSRTKFGTMSLNPSLPLRRMKVSETSIAFSVLALCVITSAVALVQKKGNRLKQKKET
Protein: Ceramide transfer protein (Collagen type IV alpha-3-binding protein) (A0A2U3TZL3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
XLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
Protein: Os06g0496400 protein (Q651K2)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAMVAGDEAMSVPWHDVGVVVDPEAAGTAPFDAGAGYVPSYGQCQYYYYYDDHHHHPCSTELIHAGDAGSAVAVAYDGVDGWVHAAAAATSPSSSSALTFDGHGAEEHSAVSWMDMDMDAHGAAPPLIGYGPTAATSSPSSCFSSGGSGDSGMVMVTTTTPRSAAASGSQRRARPPPSPLQGSELHEYSKKQRANNKETQSSAAKSRRERISERLRALQELVPSGGKVDMVTMLDRAISYVKFMQMQLRVLETDAFWPASDGATPDISRVKDALDAIILSSSSPSQKASPPRSG
Protein: Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) (Q9JJW5)
Organism: Mus musculus (Mouse)
Function: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11114196}. Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.
Interaction partners:
- Telethonin
- Alpha-actinin-2
- Cysteine and glycine-rich protein 3
- Myosin light chain 3
- LIM domain-binding protein 3
- Leiomodin-2
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Creatine kinase S-type, mitochondrial
- Titin
- Myotilin
Sequence:
MLSHSAMVKQRKQQASAITKEIHGHDVDGMDLGKKVSIPRDIMIEELSHFSNRGARLFKMRQRRSDKYTFENFQYESRAQINHNIAMQNGRVDGSNLEGGSQQGPSTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAELRDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLLTDPRFLAFANPLSGRRCFNRAPKGWVSENIPVVITTEPTEDATVPESDDL
Protein: Activin_recp domain-containing protein (Q9GUJ2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSHHLLLYFVLIAGFLLTVETKNECYSCSGVCHNENCNCQMGSCESSQCFIEKKPTEIPGSMKITKGCLRRTSRIHHGCEHDHFSDHILCVCQGSYCNDRIVMNTTRQKYTRTIQCRECSEKNPNCGSSCEGHWCHEDMSTGASGCGYGPPALPFYYRGPELFYYRSKVCITLSRGAGKPRRHCICNTANCNNVYNFQYIARDREKESSLRSRSLTLSATDYTLPLQTCYNCETNTQDATAMSHTTNCRSNRCLGHYCTYAAQRHTSKSSMGRSNLVHAVSELQGCMNVSDKTHIQIGCSKKWISDEYEEIHCACRGNLCNSDSLTATSPKLLQIVHVLLLLPAVLYHHFLA
Protein: Antimicrobial peptide Ar-AMP (Q5I2B2)
Organism: Amaranthus retroflexus (Redroot amaranth) (American pigweed)
Function: Chitin-binding protein that inhibits the growth of the fungal pathogens B.cinerea, F.culmorum, H.sativum and A.consortiale, but not that of R.solani. Induces morphological changes in the fungal pathogens F.culmorum, H.sativum and R.solani, but not in A.consortiale and B.cinerea. Has antibacterial activity against the Gram-positive bacterium B.subtilis, but lacks antibacterial activity against the Gram-negative bacterium E.coli.
Interaction partners:
Sequence:
MVNMKSVALIVIVMMAFMMVDPSMGAGECVQGRCPSGMCCSQFGYCGRGPKYCGRASTTVDHQADAAAAAATKTANNPTDAKLAGAGSP
Protein: Coilin (A0A8I5ZUZ7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSKMAASETVRVRLQFDYPPPATPHCTVFWLLVDLNRCRVVTDLISLIRQRFGFSSGALLGLYLEGGLLPPSESARLVRDNDCLRVKLEDQGLPEALIVSNGGDSNFPCRKSKKRAFKLVEDEETDQGYKYPDKYWKRQEDSGPNEKASDLETKLFPDEVRRTKNKRKSKVAGIPAEEDEEETKKKSSKRKEKCEQKKQTRASKSPKQQTHKEGGSQNCSFPRASYRSSLAKARRRSSTGAKGSPSYLSESESCPDSVSDGHCSVTTMQGVTLSEKLSAELLKDGATKTAAANRQSSKPSFTFSSGKGKASRASSSSSDSSSESEDQFLVSKNMLEGASDFLKTTGLFAGQGCSSPGLSLETPGIMGWKPSDSNRGRQAPGPNVPVPTSLGRGWGRGEDFLFGKGLRGRGIRGRGRGRGQTVSCILNRSSESQKQKQLNDILTNSSTVIQNPVETSKKDYSLLPLLAAAPQVGEKIAFKLLELTSDYSPDVSDYKEGKILSHDPETQQVDIEVLSSLPALKEPGKFDLVYHNENGTEVVEYAVTQEKRITVFWKELIDPRLIIDSSSSISSK
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (A0A1D8PHG7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Mitogen-activated protein kinase kinase kinase
- Mitogen-activated protein kinase MKC1
- Spa2p
- GTP-binding protein RHO1
- mitogen-activated protein kinase kinase kinase
- Mitogen-activated protein kinase HOG1
- Rho family guanine nucleotide exchange factor
Sequence:
MASVPPLFKVPNTKRTSNNKVLPNLSIPPTSNNKNGNPNTKPSLSLNQNIINHDSQQHENLNPLSYQPHQLQHQQYQNPQGLKLSTSPSSVSSSKSTKRKPPPIDTKVISHSPDMMDVDQQGSADESVNVDENEYSVKHHLEQLTPYDWHLIANANKIVEISSLGEGNGGAVTKCYIPQLPNKQIFALKLVMCDPNPDLQKQIFRELEVAKKCQHPNIVKYYGTFLLEKQSMIGIAMEFMDGQSLDSIYKEVLKRDKTNRINEKVLGKIANSILSGLDYLHSKNIIHRDIKPSNILLDTKGNVKLCDFGVSGEAVNSFASTFVGTQYYMAPERITGGNYSITSDIWSLGMSLLEVANGCFPIIQSLGPIEVVEIISRSNLELKDCEEDNIFWTREFKQFIAKCLTKDYLRRPKPSDLLAHDEWCLIQSKEKVKMDKFVKVVWELNE
Protein: B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) (O00512)
Organism: Homo sapiens (Human)
Function: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Catenin beta-1
- Pygopus homolog 1
- Pygopus homolog 2
- Hepatocyte nuclear factor 4-alpha
- Transcription factor 7-like 2
- B-cell CLL/lymphoma 9-like protein
- Transcription factor 4
- Transducin-like enhancer protein 1
- LIM domain-binding protein 1
- Histone H3.1
Sequence:
MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
Protein: Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) (A2ABH1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFPPSGSTGLIPPSHFQARPLSTLPRMAPTWLSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQMSS
Protein: Microtubule-associated protein (Q9VB15)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU000686}.
Interaction partners:
- Cyclin-dependent kinase 5 homolog
- Presenilin homolog
- TAR DNA-binding protein 43
- Microtubule-associated protein futsch
- E3 ubiquitin-protein ligase CHIP
- Protein kinase shaggy
- Tyrosine-protein kinase-like otk
- Huntingtin, isoform A
- Caspase-8
- Methionine aminopeptidase 2
Sequence:
MYGTGKDRSGQEIISPQDYPVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESSDSSVERKKEQPSAQLSTDYTNSNTTSDSASYGSDSVSKQQIRSQQNPEYQNNAYEAPRDDRSQLQPQRSQPATDYSAYERQQRPPPTTLDYTTGYNAPPKDRTTLSRTNSRPTLSSPNPKLQSIPNTEYVRPPQNFVLPPQMRPAVGPPQPRPPFAGARPMVGMGPRPPMPPNMAARPPPLRSTDSKSNLLMGPPMRPGMPPQLNMQQARLPNAGGQLSPPGQGPPRPPGGFPWNPAGAPGMPPGARPPQNMTRPPPPTFARPPPGQPLQAPFNRPPFNQPPMQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASAHNNNDDDDDVVMGPAVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPAGESKKGPGFKGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSSKPDKSGTSRPPSATPSNKSAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKGGEKKIVTTKLQWNAKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEIKAQSKVGSLDNVKHKPGGGEKKIFDDKDYLKNVEHSVALTTPPTQSPLPSMTASGADENLNQQS
Protein: Mammary gland factor STAT5A (Q9R0X9)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
ELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRITRADRRGAESVTEEKFTVLFESQFSVGSNELVF
Protein: Lariat debranching enzyme (EC 3.1.4.-) (Q923B1)
Organism: Mus musculus (Mouse)
Function: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- CWF19-like protein 1
- Exportin-5
- Ribonuclease 3
Sequence:
MRVAVAGCCHGELDKIYETLALAERRGSGPVDLLLCCGDFQAVRNEADLRCMAVPPKYRHMQTFYRYYSGEKKAPVLTIFIGGNHEASNHLQELPYGGWVAPNIYYLGLAGVVKYRGVRIGGISGIFKSHDYRKGHFECPPYNSSTIRSIYHVRNIEVYKLKQLKQPVHIFLSHDWPRNIYHYGNKKQLLKTKSFFRQEVENSTLGSPAASELLEHLQPAYWFSAHLHVKFAALMQHQATDKDQAGKETKFLALDKCLPHRDFLQVLEIEHDPSAPEYLEYDVEWLTVLRATDDLINVTGGLWNMPEDNGLHTRWDYSATEETMKEVMEKLNHDPKVPCNFTMTAACYDPSKPQTQVKLVHRINPQTTEFCAQLGITDINVMIQKAREEEHHQCGEYEQQGDPGTEESEEDRSEYNTDTSALSSINPDEIMLDEEEEEEEEEEEAVSAHSDMNTPSVEPASDQASDLSTSFSDIRNLPSSMFVSSDDASRSPASGEGKCGETVESGDEKDLAKFPLKRLSDEHEPEQRKKIKRRNQAIYAAVDDGDASAE
Protein: Heat shock 70 kDa protein BIP1 (Luminal-binding protein 1) (OsBiP1) (Q6Z7B0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Key chaperone involved in folding of secretory proteins in the endoplasmic reticulum (ER) lumen (Probable). Involved in ER quality control for seed storage proteins during seed maturation. Functions as a sensor of the ER stress response, and provides suitable conditions for the production of secretory proteins by alleviating ER stress.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:19567376, ECO:0000269|PubMed:9177027}. Note=Localizes close to the endoplasmic reticulum (ER) membrane complex of developing endosperm cells. Localizes to the periphery of the prolamine protein bodies which originate directly from the ER. {ECO:0000269|PubMed:9177027}.
Interaction partners:
- Os02g0710900 protein
- Endoplasmin homolog
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Calnexin
- Protein disulfide isomerase-like 1-1
- DnaJ protein ERDJ2
- Co-chaperone Hsc20 family protein, expressed
- Os09g0512700 protein
- Derlin-1
- Protein disulfide isomerase-like 1-4
Sequence:
MDRVRGCAFLLGVLLAGSLFAFSVAKEETKKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDSERLIGEAAKNQAAVNPERTIFDVKRLIGRKFEDKEVQRDMKLVPYKIVNKDGKPYIQVKIKDGENKVFSPEEVSAMILGKMKETAEAYLGKKINDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLATNGDTHLGGEDFDQRIMEYFIKLIKKKYSKDISKDNRALGKLRREAERAKRALSNQHQVRVEIESLFDGTDFSEPLTRARFEELNNDLFRKTMGPVKKAMDDAGLEKSQIHEIVLVGGSTRIPKVQQLLRDYFEGKEPNKGVNPDEAVAYGAAVQGSILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSMTKDCRLLGKFDLSGIPAAPRGTPQIEVTFEVDANGILNVKAEDKGTGKSEKITITNEKGRLSQEEIDRMVREAEEFAEEDKKVKERIDARNQLETYVYNMKNTVGDKDKLADKLESEEKEKVEEALKEALEWLDENQTAEKEEYEEKLKEVEAVCNPIISAVYQRTGGAPGGGADGEGGVDDEHDEL
Protein: Receptor activity-modifying protein 3 (Q7YS88)
Organism: Sus scrofa (Pig)
Function: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. {ECO:0000250|UniProtKB:O60896}.
Interaction partners:
- Calcitonin gene-related peptide type 1 receptor
- Pro-adrenomedullin
- Receptor activity-modifying protein 2
- Receptor activity-modifying protein 1
- Calcitonin receptor-stimulating peptide 1
- Calcitonin receptor-stimulating peptide 3
- Calcitonin receptor-stimulating peptide 2
- Calcitonin receptor
- GNAS complex locus
- Islet amyloid polypeptide
Sequence:
MEATAPRRRHLLPLLLLLLLLCGECPPVSGCNEKRMLAMLPRCGKTFAEMMKKVEVWKWCNLSEFIVYYESFTNCTEVETNVVGCYWPNPLAQSFITGVHRRHFHNCSVDRQQWQDPPDEILIPLIVVPILLTLAMTGLVVWRSKRAAQVV