wanglab/gogpt-training-data huggingface dataset:
Protein: CRAL-TRIO domain-containing protein (Q1ZXS6)
Organism: Caenorhabditis elegans
Interaction partners:
- Dietary restriction over expressed
Sequence:
MSLLPLNTLSEAGCLFIEARLLGGPGNIISQIGLTVDAPNTSIAVFSRTSGVLLVAGVGSFFAYRVASNLLGNRFVWECMDARRVDQLPTADRRLLYSFAAAEEEDAEDDEDAEVDAEHGGIRRRRTDSEGSRISVGQASLGRLNRIRKSTRTPRGLLGSLQETPRRRAGIVSRQSSRHSVASGHSLASIPFSSNSSVKSASFRIVWEGSQPSWDDFDTPSTSAGVQRGTPGAPQPSVLSRLGHVASTSSLRRFEDGQSVGDLCSVFNDVMSVRSLAEGSDDPLLDDEFRYDEEDSDGIWKKCTDDAKYMYQSIAIEASEAGSEGGGSPIKRQLLELGIDNDDDRTETLLSPPDSEGAMSRSQHSKGQRSSMYDSAIGAEISSSEEGSTCPKRLYVLQESDNMSIVAPSCASLEWCDDIDRNGPSRIGFDEEGSSPQRLRRANLDWDLESEVAVQRALSIASSSVTREIEPKFAPKMSRDLMVMACEIFQPYSPPFRDLQTIYHKRRLKRVAVPSVTESNESCVSLFMRSALYHKCSLLRDATWSIIEKRFDNAVQECDFMNKWPGYSPSSMRKDLKKLHDLASTDSLSGLEEDHHKAYQVLMVLEAKRAYDERLAGLFCEDWFNVDSPADIFKILVDRGDDDLPPKILWNILCRISGVSIEIIDARGLSEHPKINRFSASASPISAPCLTWLRLGKRPVPLFYIPDDE
Protein: Pre-mRNA-splicing factor cwf22 (Complexed with cdc5 protein 22) (Q9P6R9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in pre-mRNA splicing.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-processing factor 19
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cwf14
- ATP-dependent RNA helicase fal1
- Pre-mRNA-splicing factor brr2
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf4
- Pre-mRNA-processing protein 45
Sequence:
MEKEDKSFGIGMLDYNRENPESSGHSRVAVIRKQKTEQENNNLSWEDRHYIPDLHKSNKIKTPTSLADEKKSHNELDPKAQIKKLMETRSGGTYIPPAKLKALQAQLTDVNTPEYQRMQWEALKKSINGLINKVNKSNIRDIIPELFQENIIRGRALYCRSIMKAQAASLPFTPIYAAMTAVINTKFPQIGELLLTRLIVQFRKSFQRNDKSMCISSSSFIAHLINQKIAHEIVGLQILAVLLERPTNDSIEIAVMLLREIGAYLAEVSTRAYNGVFERFRTILHEGQLERRTQFIIEVLFQTRKDKFKNNPTIPQELDLVEEEDQITHYISLDDNLDVQESLGIFHYDPDYEENEKKYDAIKHEILGEEDDDENEEDEEDSEETSESEEDESVNDEKPQVIDQTNASLVNLRKSIYLTIMSSVDFEECCHKLLKIDLPEGQEIELCNMVIECNSQERTYAKFYGLIGERFCKLSRTWRSTYEQCFKNYYETIHRYETNRLRNIALFFANLLSTDSIGWEVYDCVRLTEDDTTASSRIFLKIMFQEIVEALGLKSLVERLHDPNLVPYLHGLFPVDEARNVRFSINYFTSIGLGALTEEMREYLLTMPKSEPKEQDSEGYSSGSETGSTYSSSYSSTYSRGRSYSRSTRSYSKSRSYSRSRSVTPINNINHKKYIRKDRELSPRGRERSSNRNSYSDLSRSSSLSRGRSRSYTPEGRLIESEDKGYRSRSSSPASRKYRSRQRYRRSYAGSTSRGRSFSRSPSYRRRLSMSCSVSYSRSPSPAARPISRSPARNKRSYDSLSYNRQYSPKVSRKRSNESRSPSPYTLRKQKTYHLNKRNEDFVVKMDKKGSESPVILAPWLREVDDGELYKDRNSESDSVRKQPRAD
Protein: WAP four-disulfide core domain protein 12 (Putative protease inhibitor WAP12) (Whey acidic protein 2) (Q8WWY7)
Organism: Homo sapiens (Human)
Function: Antibacterial protein. Putative acid-stable proteinase inhibitor.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- WAP four-disulfide core domain protein 5
- Semenogelin-2
- Semenogelin-1
- Elafin
Sequence:
MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGERKCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK
Protein: Secretoglobin family 3A member 2 (Pneumo secretory protein 1) (PnSP-1) (Uteroglobin-related protein 1) (Q96PL1)
Organism: Homo sapiens (Human)
Function: Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:12847263}.
Interaction partners:
- Uteroglobin
- Pulmonary surfactant-associated protein A1
- Surfactant protein C
- Macrophage receptor MARCO
- Pulmonary surfactant-associated protein B
- Forkhead box protein J1
- Homeobox protein Nkx-2.1
Sequence:
MKLVTIFLLVTISLCSYSATAFLINKVPLPVDKLAPLPLDNILPFMDPLKLLLKTLGISVEHLVEGLRKCVNELGPEASEAVKKLLEALSHLV
Protein: Type II methyltransferase M.AplI (M.AplI) (EC 2.1.1.37) (Cytosine-specific methyltransferase AplI) (Modification methylase AplI) (D4ZX35)
Organism: Arthrospira platensis (strain NIES-39 / UTEX 3086 / IAM M-135) (Spirulina platensis)
Function: A methylase, recognizes the double-stranded sequence 5'-CTGCAG-3', methylates C-4 on both strands, and protects the DNA from cleavage by the AplI endonuclease.
Interaction partners:
Sequence:
MSNRLSYWEYLHQELKLNADIQSQLVVLDLFAGCGGFSLGFKAAGFQTIGYEMLADAAATYTRNLQDPCYCQTLEIGQDLCNHPDVIIGGPPCQPFSVGGLQKGPRDSRDGLPIFIDAIARYQPEIAIFENVRGMLYKNRQYLEKIVAELERLNYRVDIKLINAVNYGVPQKRERLFVVAYQTAWNWPEAETLAIPYTAGDAIYDTASTIPIGAKFLTPSMLEYIGRYEAKSKCVKPRDIYLDIPCRTLTCRNLSGATSDMLRLLLPDGRRRRLTVREAARLQSFPDWFELVGSENSQFNQIGNAVPPLLAKAIAKSVKMTLENKPSRPTDYFSPFPQQLKLPFA
Protein: Integrator complex subunit 1 (Q9W1C5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Required for the normal expression of the Integrator complex component IntS12. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:23288851}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:39032490}.
Interaction partners:
- Integrator complex subunit 5
- Integrator complex subunit 11
- Protein asunder
- Integrator complex subunit 10
- Integrator complex subunit 7
- Integrator complex subunit 9
- Integrator complex subunit 4
- Integrator complex subunit 2
- Integrator complex subunit 12
- Integrator complex subunit 3
Sequence:
MDRGKGSGSNRSQKKVPLGGELFALGKSVRDDSKSKILPIKGMSSSDRKREASTALASSSKRFRGNLKDAGAPDMSSGSSQCETWEQFAVDCDLDTVVETIYAALEQNDSETVGRLVCGVIKQTTTSSSRSKVDNIALLALIYVAKVQPSIFCTDIVACALLSFLRREANVKMRYNTNLHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICAAFKTRTPHISLLRWDVSSSLPSGQAHRDSMTVDDDSGDNSTQSLDASPLNTESEPIPDAMCTTKSRFSDAVVQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWIHNGKLVKFAQQLLSYICFNIKGRNTQDNEVLLVLVKMRLKTKPLINHYMSCLKEMIFLQPEILSTVMKLVVQNELSNTRNPNNMGMLATMFQTSADQSAATLAEIYQEFLLQRDDCLRTLRVFLRELVRMLRFDVNLVKFCKTFLSEREDLTPQIEMFEFKERIFNSMVDIVCLCMFLSATPQAREASLSLKTNRDTKNNHALLKLYNQMSQIQLDTVSWMYETVPTLFKIPAAEYHQALHKLLLLDSPEQYSRCDQWPSEPERGAILRIISETPIHEETLLRIILIGITKDIPFSIANTFDVLLLVIKRVSGMKATNIPAVQANKFDIIDFLFSMSEYHHPENIRLPAEYEPPKLAIIAFYWKAWLILLMISAHNPSSFGAFCWDHYPTMKMMMEICITNQFNNSSATKDELQIITMERDHILQFETYLAAQTSPHAVITEETAILITQLMLMDPMGTPRKVPSMVLDQLKFLNQTYKLGHLFCRCRKPDLLLDIIQRQGTTQSMPWLSDLVQNSEGDFSHLPVQCLCEFLLFNAHIINEENSRDAELVNFLRNLIFDGNLSHQIVCELLDYIFRRLSSTVKQSRVAALSGLKIIFRHSGDFENEWLLKSLQQIPHFYEVKPFIIPQLRAACQVENCPELIMAYIQFITAHTLNDPVNEMLDHVIDMAQLIVERSTMFQHIIISQEDYDYVPDENRIQTLKCLFVMFNNYIIKLREYHEPYEWTEYPDLLMVQFDDGVQLPLHINIIHAFIILLTYSNSNMPESIPILDYWFPPGRPAPVAFLPSMPQEQVQLLPDWLKLKMIRSSVDRLIEAALNDLTPDQIVLFVQNFGTPVNSMSKLLAMLDTAVLEQFDLVKNAILNKAYLAQLIEIQQARGAKNGHYTVQALDLHSHSQTVPDLPKISVVIQEAVEIDDYDSSDSDDRPTNFLATKEVAQTILTQPDQLTESRSDCRSLIQKLLDMLASPNSNRADVVNAITEVLAVGCSVTMSRHACTFLRTFFSCMLHSDKYHILENALQKNLSMFKHTFADSSLLQKSELYHESLVFMLRNSREIYAQQFKANTALVARKRIVRAIVQSFDQTKDSKTVAKSKSDQLFHNGLFIDWLSEMDPEIVSTQLMKERFLFSKSCSEFRFYLLSLINHQTNWDTIERIAEYLFKNFHEDYDYATVLNYFEALTTNPKLWKGRDKYMSKNVRPDAFFMLRTSELEPFSHFILHEGLSEVKLDSKNYDFKLCSRMNLLFKLTEKRRDLMVKVMEHVEKSSVSDYLKLQVLQQMYIMYPRIKFLKPGKTGEQAYKLQNLKGCQADKVSNNLITCLGSLVGKKDFETLSTDTELLLRKLAASHPLLFLRQLGVLSSIMQGRAQLSMKALREEHHFHRFVQILRTLELLQPTIFEEAYKNEIQNTLSCYFNFFKHHSNVKEACQMLNKFVQMLQAYINYNPSSALLFIEQYVGILKELAAKYTSLGKLQVLVQAVALLQHKSHSATELDDEEVKYEYDLDEHFDVKPSASKPVVTEDPIEVNPQTPIDPSSSRGPLSVLTLGSYSRSNYTDISPHFLDLVKIIKQSNTEDVVLGPMQELECLTSKRFVFINELFERLLNLIFSPSAQIRSIAFIILIRHLKHNPGNSDINLCTLNAYIQCLRDENSSVAATAIDNLPEMSVLLQEHAIDILTVAFSLGLKSCLNTGHQIRKVLQTLVIQHGY
Protein: Small nuclear ribonucleoprotein-associated protein (Q66K91)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037187}.
Interaction partners:
Sequence:
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMGRGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGLL
Protein: Interleukin-6 (ChIL-6) (IL-6) (Q90YI0)
Organism: Gallus gallus (Chicken)
Function: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05231}.
Interaction partners:
- Uncharacterized protein.
- Interleukin-6 receptor subunit beta
- Interleukin-1
- Interleukin-10
- Signal transducer and activator of transcription 3
- Interferon gamma
- Uncharacterized protein.
- Toll-like receptor 4
- Interleukin-4
- Uncharacterized protein.
Sequence:
MNFTEGCEATGRRPGSAGSRRRRAPRPGPVALLPLLLPLLLPPAAAVPLPAAADSSGEVGLEEEAGARRALLDCEPLARVLRDRAVQLQDEMCKKFTVCENSMEMLVRNNLNLPKVTEEDGCLLAGFDEEKCLTKLSSGLFAFQTYLEFIQETFDSEKQNVESLCYSTKHLAATIRQMVINPDEVVIPDSAAQKSLLANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYLKKTRSFSA
Protein: Uridine 5'-monophosphate synthase (EC 2.4.2.10) (EC 4.1.1.23) (F7FPV0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEVARQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTARNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHSVCTLSEMLEILEQQKKIDAEMVGRVKRFIQENVFTAANHNGVPPPEKKACKELSFGARAELPGVHPLASKLLTLMQKKETNLCLSADVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTTLAKRHEFLIFEDRKFADIGNTVKKQYESGIFKIASWADVVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGDYTKAAVGMAEEHCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVVGKRGSDVIIVGRGILAAANRLEAAEMYRKAAWEAYLSFTAVNRHHDQGKSYKNSM
Protein: Puratrophin-1-like, isoform D (M9PEF7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWISIFMTGDASTMAYVIWKIFMKQYARLHYDPRPLSPKLIWHSYAAIQTADTNIETGRAEAAVTGSGAGAELAEILVPSDTQIDVPGGGIPGGQIPSLESTDRDMKEARAAPIARDDEDQEAGDPEEHGEEEDEEPPEVEQLSANANYVCCRYPGTTSSSTSGAADTLNRSKSRVQKYLKKCKQRLTGQAKMPTSSSTTTTTITLIRNEPAPTTIAERESEQALAEQEEELLEVEDLTEGSNGSYTDALPIECSLSASIAEEQQQGVDELEPPKEEEVPLETELTEPSSTPPPQSNPEGIPAPERFRLTADVDATLARLIDSHLSHIYPVYWARTRAILIQQARERLVCGFDGSLVRFEQRFLCKFAQIAATLRTAHQIGESWLWHPGWPLATSNGALVLQLSDAEIAHALRPSELYLCIKLESTESDADCKPRLYAVWRSSRKEESVQSHCIDHENPGELPLSVLQLEMSTAAAALMASDCGELPQLLQNLLVSVERSIERVSLNELQMPMHHDRGEDSLDEANNNGCNNNLLGSPKCALRRSDLITKNKLFNSRYMLRRLTNRQDSMNSTSSGNSNVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNSVGNEASGASTSPALPLYCLGNSFPHIDSDEEASDSIGPGKHHSLETCETELLPSSSIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAACVASAGINCYEMATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMRKTHTLPVASSTPAAAAGKRVSYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSLSSGTSTTSGSSISGGSSSGHNDGGGRHSLHFGKLPGAHSASSTNCSATLELINETQALKLAKSPSGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQLSMESGIVSDMCVTPDQEQSAAESSRSSWSTSTTGASGASTTSASTVILRRYRSYAHAAESASPESGK
Protein: 3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1) (Q06136)
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15328338, ECO:0000269|PubMed:19141869}; Multi-pass membrane protein {ECO:0000269|PubMed:15328338}.
Interaction partners:
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase 2
- Serine palmitoyltransferase 3
- Ceramide synthase 6
- Ceramide synthase 2
- Sphingolipid delta
- Ceramide synthase 3
- Sphingolipid delta
- Ceramide synthase 5
- Ceramide synthase 4
Sequence:
MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA
Protein: Phosphatidylglycerophosphate phosphatase PTPMT2 (EC 3.1.3.27) (Protein TYROSINE PHOSPHATASE LOCALIZED TO THE MITOCHONDRION 2) (Putative dual specificity protein phosphatase PTPMT2) (EC 3.1.3.16, EC 3.1.3.48) (Q6NKR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exhibits phosphatidylglycerophosphate phosphatase activity. Involved in root growth and columella cells organization. May possess protein phosphatase activity (By similarity).
Interaction partners:
- Probable protein phosphatase 2C 10
- Metal ion-binding protein
- acid phosphatase
- Mitochondrial carrier protein MTM1
- Dual specificity protein phosphatase PHS1
- Inositol diphosphatase DSP4
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
- Inositol diphosphatase DSP2
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B
- Inositol diphosphatase DSP5
Sequence:
MTDETEEDDTTQQRSSRNDGVSKNKGKGFKGDKAKRALIGAGGRILFYPTLLYNLVRFKLQSQFRWWDQIDEYLLMGAVPFRKDVPRLKKLGVGGVITLNEPYETLVPSSLYSAYEMEHLVIPTRDYLFAPSIVDITLAVNFIHKNALLGKTTYVHCKAGRGRSTTVVLCYLIEHKSMTVAAAFEHVRSIRPRVLLHPSQRKVVEEFSRLQSPLSESTFIATSGDIVS
Protein: Dynactin subunit 3 (X6RLR1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQIPILTLTYNQTMLLSKQFVQWDELLCQLEAATQVKPAEE
Protein: CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) (A0A1D8PF32)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 2
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Phosphatidate cytidylyltransferase
- Phosphatidylethanolamine N-methyltransferase
- Lysophospholipid acyltransferase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Tryptophan synthase
- Cardiolipin synthase
Sequence:
MSDSSATGFSKHQESAIVSDSEGDAIDSELHMSANPPLLRRSSSLFSLSSKDDLPKPDSKEYLKFIDDNRHFSMIRNLHMADFITLLNGFSGFYSIISCLRYTLTGQTHYVQRAHFFILLGLFFDFFDGRVARLRNKSSLMGQELDSLADLVSFGVSPATIAFAIGFRTTVDVLFLAFWVLCGLTRLARFNISVNNIPKDKHGKSQYFEGLPIPTNLFWVGFMALLVYKDWIHDNLPFGIVFQDTSFEFHLVTIGFVLQGCAEISKSLKIPKP
Protein: AT07931p (Q8IHF0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDMNALDYEQQTESEAESEDEEQLKVKPPNKQDIRVEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPPRRQQRSPARRPGQNYNQNQNQNQNQNQNQLNRGNRRNPFADRDRRRRSRSQDNEYRNRYPLSPIRGRGSPGGDRRRQQRSRSQNRRQDSPSQRRQLSPGRKRQDSPSKKRPNSTERKWRDSPERKREASPNWKRDDSPARKRKDSANRKREDSQDKKIQDSKRQEDSAGKKREDSPSKKRKDSDKKRQDSPVKRQESPGRKRQDSPERKRRDSPDRRRKDSPARRRQESSGRRRQDSDGRRRRESSGNRRSRSRGRWHSSSRSRSPSTSRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQKRAEAAMLMKEHMRNEIAKEEERRMEKQRQDDLDKERTTRELNELERLKAETLRKLHEEDSVDPDAAASAGSASKTDATSTGAKSKRDSSSENRHREKKRKHKKSKKSSGRSDND
Protein: Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) (Q96EK6)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Phosphoacetylglucosamine mutase
- Glutamine--fructose-6-phosphate aminotransferase 1
- Glutamine--fructose-6-phosphate aminotransferase 2
- N-acetyl-D-glucosamine kinase
- Glucosamine-6-phosphate deaminase 1
- Glucosamine-6-phosphate deaminase 2
- Hexokinase-1
- N-acetylglucosamine-6-phosphate deacetylase
- Hexokinase-3
- Hexokinase HKDC1
Sequence:
MKPDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCRRFLK
Protein: PML nuclear body scaffold (A0A8I6GKM3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPPPEEPSEDHEHSQSPAEQAIKEEFQFLRCPGCQTQAKCPKLLPCLHTLCSGCLEAPGLQCPICQAPGSANANAEALDNVFFESLQRRLAVFRQIVDAQAACTRCKELADFWCFECEQLMCGKCFDAHQWYLKHEARPLAELRDNSVREFLDSTRKSNIFCSNTNHRTPAQTNIYCRGCAKPLCCECALLDRNHSHLQCEIGKEIQQLHEELGTMTQALEEQGRTFDSAHAQMHSAIGQLDDARSDTEKQIRARVRQVIEHVQAQERELLEAVNVRYQRDYQEIAGQLGHLEAVLQRIRTGGALVKRMKLYASEQEVLDMHGFLRKALCRLRQEEPQNHKVQLRTSGFEEFKLCLQDLVSFITQRTDVAVAGRASPEAASTHPEAASAQPEAASAQPEAASAHPESASTPGNSTDLEQPKEVQRAQAQAMELSKTQPVAMVKSVPGAHPVPVYAFSMQGPTYREEASQTVSPMKRKCCHIDCCRKIIKMESTDENEDRLSTSSPEQPRPSTSKAISPPHPDGTSSTESTIPEKETPLPNNNHVASDAGETEERIVVISSSEDSDAENLPSHELDDSSSESSSIQLEGPNSLKALDESLAEPHLEDRTLVFFDLKIDNETQKISQLAAVNRESKFRVLIQPEAFSVYSKAVSLESGLQHFLSFLNSMHRPLLACPRLWGPGLPIFFQALNDINKLWEFQDAISGFLAVLPLIQERIPSASSFKLRNLAKTYLARNMSERSALAAVLAMRDLCCLLEVSPGLQLAQHIYSFSSLQCFASLQPLIQAQVLPQPEARLLALHNVSFLELLTAYRSNRQEGLKKYVHYLSLQTTPSSASTQIAQFLQALSAYMDGQLEGHIPAGAEGTALSLSGRAENKGCLA
Protein: Succinate dehydrogenase subunit 3-1, mitochondrial (P0DKI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Succinate dehydrogenase subunit 5
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Succinate dehydrogenase subunit 4
- Succinate dehydrogenase subunit 6
- Succinate dehydrogenase subunit 3-2
- Succinate dehydrogenase subunit 7A
- Succinate dehydrogenase subunit 7B
- Succinate--CoA ligase subunit alpha-1, mitochondrial
Sequence:
MAATALFRSIRRRDVVSAPLSVYKSLAGNAQPSWGSSYIGQNYASFSRAFGSKPVVNDILGTGLGTNNAIREEREKSKSTEAAIVGAQLTRSFRALDVGTSKRLFSTISGDIKTTQEEPKIKSFRPLSPHLSVYQPQMNSMLSIFNRISGVYLTGVTFAGYLLYLKMGMICLTYPSFYQVLYHTQQQLPVITSVTALAAIYHTIKSTHSLLTH
Protein: Aspartate aminotransferase (AspAT) (EC 2.6.1.1) (O69689)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Main aspartate aminotransferase that couples nitrogen assimilation to aspartate synthesis. Has a weak, but significant, side activity toward kynurenine (Kyn). Oxaloacetate and 2-oxoglutarate, but not pyruvate, serve as amino acceptors, while Asp, Glu and Kyn serve as the best amino donors. Essential for axenic growth and survival of M.tuberculosis in macrophages and in mice.
Interaction partners:
- DNA polymerase III subunit gamma/tau
- UPF0073 membrane protein Rv1085c
Sequence:
MSFDSLSPQELAALHARHQQDYAALQGMKLALDLTRGKPSAEQLDLSNQLLSLPGDDYRDPEGTDTRNYGGQHGLPGLRAIFAELLGIAVPNLIAGNNSSLELMHDIVAFSMLYGGVDSPRPWIQEQDGIKFLCPVPGYDRHFAITETMGIEMIPIPMLQDGPDVDLIEELVAVDPAIKGMWTVPVFGNPSGVTYSWETVRRLVQMRTAAPDFRLFWDNAYAVHTLTLDFPRQVDVLGLAAKAGNPNRPYVFASTSKITFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDADGVRLHMLRHQQILAPKFALVAEVLDQRLSESKIASWTEPKGGYFISLDVLPGTARRTVALAKDVGIAVTEAGASFPYRKDPDDKNIRIAPSFPSVPDLRNAVDGLATCALLAATETLLNQGLASSAPNVR
Protein: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase (EC 2.4.1.153) (Dol-P-GlcNAc synthase) (B3VA58)
Organism: Methanococcus voltae
Function: Involved in the assembly of an N-linked disaccharide that decorates the S-layer glycoprotein and flagellins. AglK initiates N-linked glycosylation through the formation of alpha-linked dolichyl monophosphate N-acetylglucosamine. It catalyzes the transfer of GlcNAc from the donor substrate UDP-GlcNAc to dolichyl phosphate C55 (Dol-P) to yield Dol-P-GlcNAc. AglK reaction proceeds with retention of stereochemistry. The reaction is specific for UDP-GlcNAc. AglK shows a stronger preference for short dolichol (C55-60 Dol-P) substrates compared with the longer (C85-105 Dol-P).
Subcellular location: Cell membrane {ECO:0000305|PubMed:23624439}; Single-pass membrane protein {ECO:0000305|PubMed:23624439}.
Interaction partners:
Sequence:
MADKLIYLIIPAYNEEKMIKNVVNNLQNHNYDNIIIVDDGSKDNTYKIMKELEEESKQNNNNNNNNNNNKVIAIKHEQNKGVGGATITGLKKAYELGADIAVTFDADGQHAPDDIAKVIQPIINDSKEYVVGSRIKNPKEFKNMPLTKKVGNLGLSFITFLLGGYYVTDSQSGLRAFSKSALKVLSEQLRAKRYETCSEALIIAKKNKLNIGEVPIKTIYTEYSMARGTNVMIGFKIFYRLLMLKMGKVLD
Protein: Ectopic P granules protein 4 (Q20123)
Organism: Caenorhabditis elegans
Function: Involved in autophagy. Thought to act in autophagasome and omegasome formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20550938}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Forms a reticular pattern throughout the cytoplasm.
Interaction partners:
- Ectopic P granules protein 3
- Ectopic P granules protein 5
- Ectopic P granules protein 2
- Ovule protein
- Ectopic P granules protein 6
Sequence:
MVKFQIIARDFYHGFIDSFKGITFVRRIREEEAKEVKVEPPKPVERTVLMMRREKQGIFKRPPEPPKKKDSFLKKLWQIYAMNIGFLVLWQVCILILGLFFSFFDRTDLGHNIGYILIIPIFFASRIIQALWFSDISGACMRALKLPPPPVVPFSSMLAGTLISALHQIFFLIQGMLSQYLPIPLITPVIVYLHMALLNSMYCFDYFFDGYNLSFLRRKDIFESHWPYFLGFGTPLALACSISSNMFVNSVIFALLFPFFIITSYPANWNRKYEEEIPKIAFCRISYMFTELVGKFVKSITPTNNPTAARNNAQN
Protein: SWI/SNF complex subunit SMARCC2 (H8ESF3)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- SWI/SNF Subunit INI1 DNA binding domain-containing protein
- Bromo domain-containing protein
- HMG box domain-containing protein
- SWI/SNF chromatin-remodeling accessory subunit 2
- Actin-related protein 4
- SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4
- SWI/SNF chromatin-remodeling accessory subunit 1
- SWI/SNF chromatin remodeling complex subunit swsn-7
- ARID domain-containing protein
- Bromo domain-containing protein
Sequence:
MKKGASKRRRDDDDGDVSMTGDDDDSRSGAAVKVEVPKGKEKDAEFSAPKGQKLTDLDEEGVQSTKEAPQLAEGNVIEQTHYIVVPSYAGWFDYNAIHQIEKRAMPEFFNGKNKSKTPDVYVAYRNFMVDTYRLNPFEYVSATACRRNLAGDVCSIVRLHSFLEQWGLLNYQVDSDARPAPVAPPPTSHFMVLADTPTGIQPMNPPGKESAGASGEPPKEEIKTEIESISTPGLKIDQYQKQAIAMRTKGAPPGRDWTEQETCLLLEALEMFKDDWNKVCDHVGTRTQHECVLKFLQLPIQDPYLTENLSSDKAEAAPGGAAKEVLGPLAFQPVPFSQSGNPVMSTVAFLASVVDPQVAAAATKAAMEEFGKLKEEIPPLVAEAHEKNVAAMAEKTGQVDGAVGLTKSGLKPAEEAAGDSDEKMDTNTNDDVPSTTEAKSAIDKGVQAAAASCLAAAAVKAKHLAQIEERRIKSLVAQLVETQMKKLEMKLRHFDELEQIMDKERESLEYQRHQLILERQAFHMDQLKYLENRAKHEAHSRMTSSGALPAGLPPGFEVTGPPQPTPQVQISAQEAAIPEKMDTSEAATAARPPSTPQAPQAPPVQAAPAPVQAPQAPQAPPQAYQGYGGPGGPPQQAYRYPPQQGQQYSPYPPPQQQQQHQAQQAQSQAHYGPPGGGQGPPPPPQGQQYYGGPPPPGQPYGPPGGYPPQQQRPPYQAQPYPGPPPPQQQRGYGYPPPPQPVFSGHPYQQPYGQMPPPPHGQYQPQQQQGGPMGPPGGHHEGGDGGDSQQKQE