wanglab/gogpt-training-data huggingface dataset:
Protein: Serrate RNA effector molecule (Q9ZVD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:16889646, ECO:0000269|PubMed:17442570, ECO:0000269|PubMed:17675322, ECO:0000269|PubMed:19245862}. Nucleus speckle {ECO:0000269|PubMed:26227967}. Note=Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm involved in miRNA processing.
Interaction partners:
- Nuclear cap-binding protein subunit 1
- Nuclear cap-binding protein subunit 2
- Double-stranded RNA-binding protein 1
- Phosphorylated adapter RNA export protein
- Endoribonuclease Dicer homolog 1
- G patch domain-containing protein TGH
- Peptidyl-prolyl cis-trans isomerase CYP65
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7
- At2g29210/F16P2.41
- Peptidyl-prolyl cis-trans isomerase CYP18-2
Sequence:
MADVNLPPSDSVDNRLPEKSTSSSPPPPPPSSSLPQQEQEQDQQQLPLRRERDSRERRDERDIERPPPNRRERDRSPLPPPRRDYKRRPSLSPPPPYRDRRHSPPQRRSPPQKRYRRDDNGYDGRRGSPRGGYGPPDRRFGYDHGGGYDREMGGRPGYGDERPHGRFMGRYQDWEGGRGGYGDASNSGNPQRDGLMSYKQFIQELEDDILPSEAERRYQEYKSEYITTQKRAFFNTHKEEDWLKNKYHPTNLLSVIERRNDLAQKVAKDFLLDLQSGTLDLGPAVTALNKSGRTSEPNSEDEAAGVGKRKRHGMGGAKENELLSAAPKAPSFTSDPKRILTDVEQTQALVRKLDSEKKIEENVLQGSETEKSGREKLHSGSTGPVVIIRGLTSVKGLEGVELLDTLVTYLWRVHGLDYYGKVETNEAKGLRHVRAEGKVSDAKGDENESKFDSHWQERLKGQDPLEVMAAKEKIDAAATEALDPHVRKIRDEKYGWKYGCGAKGCTKLFHAAEFVYKHLKLKHTELVTELTTKVREELYFQNYMNDPNAPGGQPATQQSGPRDRPIRRKPSMENRLRDDRGGRRERDGRANGNDRNDRSEDQQRGDNDGGNPGEVGYDAFGGQGGVHVPPFLSDINPPPMLMPVPGAGPLGPFVPAPPEVAMQMFRDPSGPNPPFEGSGRGGPAPFLLSPAFRQDPRRLRSYQDLDAPEEEVTVIDYRSL
Protein: Opsin Rh6 (Rhodopsin Rh6, long-wavelength) (O01668)
Organism: Drosophila melanogaster (Fruit fly)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Transient-receptor-potential-like protein
- Opsin Rh5
- FI01102p
- Homeotic protein ocelliless
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Phosrestin-2
- Chaoptin
- Phosrestin-1
Sequence:
MASLHPPSFAYMRDGRNLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGKDDLTSDSRTQATAEISESQA
Protein: Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1) (Q16099)
Organism: Homo sapiens (Human)
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Subcellular location: Cell membrane {ECO:0000305|PubMed:8263508}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q8BMF5}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8BMF5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 1
- Glutamate receptor ionotropic, kainate 2
- Glutamate receptor ionotropic, kainate 3
- Glutamate receptor ionotropic, kainate 5
- MAP/microtubule affinity-regulating kinase 4
- Complement C1q-like protein 3
- Glutamate receptor ionotropic, NMDA 3A
- Glutamate receptor ionotropic, NMDA 2D
- MAP/microtubule affinity-regulating kinase 3
- Glutamate receptor 4
Sequence:
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE
Protein: Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) (Q969W9)
Organism: Homo sapiens (Human)
Function: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
Subcellular location: Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Interaction partners:
- E3 ubiquitin-protein ligase NEDD4
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Androgen receptor
Sequence:
MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
Protein: Semaphorin-5A (Semaphorin-F) (Sema F) (Q62217)
Organism: Mus musculus (Mouse)
Function: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Plexin-B3
- Semaphorin-5B
- Plexin-A3
- Plexin-A1
- Plexin-A2
- Plexin-A4
- Plexin-B2
Sequence:
MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLELEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMARCPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRPARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQGTFFLPELDLIYGIFTTNVNSIASSAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHLAVDVVQGRETLVHIIYLGTDYGTIKKVRAPLSQSSGSCLLEEIELFPERRSEPIRSLQILHSQSVLFVGLQEHVAKIPLKRCHFHQTRSACIGAQDPYCGWDAVMKKCTSLEESLSMTQWDQSIPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCRSRSCDRPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGSNVEYHPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKFGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQTCPESWSEWSDWSVCDASGTQVRARQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMFHMMAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
Protein: Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (Q5XIE9)
Organism: Rattus norvegicus (Rat)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 6
- Mediator complex subunit 12
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 10
Sequence:
MGVTCVSQMPVAEGKSVQQTVELLTKKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQAGKLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPTVFGNRHDAVYGPADTMVQYMELFNKVRKQQQVPVAGIR
Protein: Arginine exporter protein ArgO (P11667)
Organism: Escherichia coli (strain K12)
Function: Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine. May also be involved in the export of canavanine (a plant-derived antimetabolite).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01901, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:27645388}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01901, ECO:0000269|PubMed:27645388}.
Interaction partners:
- HTH-type transcriptional regulator ArgP
- Uncharacterized membrane protein YahN
- Lysine exporter LysO
Sequence:
MFSYYFQGLALGAAMILPLGPQNAFVMNQGIRRQYHIMIALLCAISDLVLICAGIFGGSALLMQSPWLLALVTWGGVAFLLWYGFGAFKTAMSSNIELASAEVMKQGRWKIIATMLAVTWLNPHVYLDTFVVLGSLGGQLDVEPKRWFALGTISASFLWFFGLALLAAWLAPRLRTAKAQRIINLVVGCVMWFIALQLARDGIAHAQALFS
Protein: CBFA2/RUNX1 partner transcriptional co-repressor 3 (H3BNH2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHFRDAYRHPDPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRSSSAGPEGPQLGKHGLVCQEAWS
Protein: Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) (P61244)
Organism: Homo sapiens (Human)
Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Subcellular location: Nucleus. Cell projection, dendrite {ECO:0000250}.
Interaction partners:
- Myc proto-oncogene protein
- Max dimerization protein 1
- Max-interacting protein 1
- N-myc proto-oncogene protein
- MAX gene-associated protein
- Transcription factor E2F6
- Mitogen-activated protein kinase 14
- E3 ubiquitin-protein ligase RING2
- Protein L-Myc
- RuvB-like 2
Sequence:
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
Protein: Transmembrane protein 18 (Q96B42)
Organism: Homo sapiens (Human)
Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}. Nucleus membrane {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glucosamine-6-phosphate deaminase 2
- BTB/POZ domain-containing protein KCTD15
- Neuronal growth regulator 1
- Melanocortin receptor 4
- Mitochondrial carrier homolog 2
- SH2B adapter protein 1
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Protein transport protein Sec16B
- Protein lifeguard 2
Sequence:
MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCLSSRSYRLQIGHFLCLVILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLLVNAMIIVVMWVWKTLNVMTDLKNAQERRKEKKRRRKED
Protein: Intraflagellar transport 43 (Q9VK67)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- WD repeat-containing protein 35
- Intraflagellar transport protein 122 homolog
- Reduced mechanoreceptor potential A, isoform B
- Outer segment 6
- Outer segment 5
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport 52
- Intraflagellar transport 20
- No mechanoreceptor potential B, isoform D
- Intraflagellar transport protein 57 homolog
Sequence:
MDWAEELKMTIRKTTARKGRRSKSRDVLKEEDVQAAGGSKDISIDITLNVQAGTPPTTSDTATSSTYNNEFESHRPPIRRISGGWADSGLKGLKSKKNSFDDERFKQTKSATNSIPTDDIPVIPDMDDVKDEIMLNEIVEPPTIGTSRSAVLKEANSDLLSQYAFSAVDGFDLSILTDCLVPQESLNEKDDLWQWDKLFTEVTAEIHSDKVPNMGMKIGPDVIPPTQYT
Protein: Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] (Q9JI10)
Organism: Mus musculus (Mouse)
Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21145499}. Nucleus {ECO:0000269|PubMed:21145499}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (By similarity). {ECO:0000250|UniProtKB:Q13188}.
Interaction partners:
- MOB kinase activator 1A
- Protein salvador homolog 1
- Ras association domain-containing protein 1
- Ras association domain-containing protein 2
- Serine/threonine-protein kinase 4
- Serine/threonine-protein kinase LATS1
- Serine/threonine-protein kinase LATS2
- Ras association domain-containing protein 6
- Ras association domain-containing protein 4
- MOB kinase activator 1B
Sequence:
MEQPPASKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFIKNAKPVSILRDLIAEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSSESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEEEEEEEEEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCDQSMREPGPMSNSVFPDNWRVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKRRQQNF
Protein: Tyrosine-protein kinase Dnt (EC 2.7.10.1) (Protein doughnut) (Q9V422)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play an essential role in neuronal pathway recognition and ventral muscle attachment site selection.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tyrosine-protein kinase Drl
- Frizzled
- Frizzled-3
- Frizzled-4
- Frizzled-2
- Protein Wnt-5
- Protein wingless
Sequence:
MESVNKCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPVPANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV
Protein: Mitochondrial fission process protein 1 (Q385C2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- MICOS complex subunit MIC10
- Thioredoxin domain-containing protein
- Transmembrane protein
Sequence:
MSLKDCGVMSQWEGEWPWLRHSVSSVRKYVWAAAAYLGPALNVSGHVATAKLYAEQADRFVAVPVSAVGETVRTKQWVIPSLGIGAASAFITAKSASWGTYRAMRNGGVTAVALTVLLFPREIISWADASLPFRVQHPKADIEDD
Protein: FUN14 domain-containing protein 1 (Q9DB70)
Organism: Mus musculus (Mouse)
Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IVP5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IVP5}.
Interaction partners:
- Microtubule-associated protein 1 light chain 3 beta
- Gamma-aminobutyric acid receptor-associated protein
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
- Microtubule-associated protein 1 light chain 3 alpha
- Serine/threonine-protein kinase ULK1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
- Gamma-aminobutyric acid receptor-associated protein-like 1
- Casein kinase II subunit alpha'
Sequence:
MASRNPPPQDYESDDESYEVLDLTEYARRHHWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQVASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNIIEEATDFIKQNIVISSGFVGGFLLGLAS
Protein: Phenylacetaldehyde dehydrogenase (PAD) (EC 1.2.1.39) (P80668)
Organism: Escherichia coli (strain K12)
Function: Acts almost equally well on phenylacetaldehyde, 4-hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde.
Interaction partners:
- Primary amine oxidase
- Transcriptional activator FeaR
- Phenylacetate-coenzyme A ligase
- Acyl-coenzyme A thioesterase PaaI
- Methionyl-tRNA formyltransferase
- 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase
Sequence:
MTEPHVAVLSQVQQFLDRQHGLYIDGRPGPAQSEKRLAIFDPATGQEIASTADANEADVDNAVMSAWRAFVSRRWAGRLPAERERILLRFADLVEQHSEELAQLETLEQGKSIAISRAFEVGCTLNWMRYTAGLTTKIAGKTLDLSIPLPQGARYQAWTRKEPVGVVAGIVPWNFPLMIGMWKVMPALAAGCSIVIKPSETTPLTMLRVAELASEAGIPDGVFNVVTGSGAVCGAALTSHPHVAKISFTGSTATGKGIARTAADHLTRVTLELGGKNPAIVLKDADPQWVIEGLMTGSFLNQGQVCAASSRIYIEAPLFDTLVSGFEQAVKSLQVGPGMSPVAQINPLVSRAHCDKVCSFLDDAQAQQAELIRGSNGPAGEGYYVAPTLVVNPDAKLRLTREEVFGPVVNLVRVADGEEALQLANDTEYGLTASVWTQNLSQALEYSDRLQAGTVWVNSHTLIDANLPFGGMKQSGTGRDFGPDWLDGWCETKSVCVRY
Protein: DCAPL3 (Q966U9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
Sequence:
MGQEHTQSTTGTAMFAPKFKARAPPGSGVWTPYGSSGDLNQSGATSATPPPPPPPSLPVWTPQPSPVLSGRKEFRPVRFESPTLPRRYTAQQQQKTTTTIPPWSSAENGEGAPPPTAPASLNSVNSNSDYAETDCSGHFGPVAPSASVSDKIRTFERSSSNSELQRPFVRRQLSDASRPAYRPNEVIYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVERA
Protein: chitinase-like effector (A0A385MIS5)
Organism: Moniliophthora perniciosa (Witches'-broom disease fungus) (Marasmius perniciosus)
Subcellular location: Secreted {ECO:0000305|PubMed:30220500}.
Interaction partners:
Sequence:
MFTPLSSVTALLALSSAFLGAQAGCKPKNYGPEKPHGGNGGNRGSGNGNSTSKFIAKGYYTGWNSDDFKPEQVSWSKYTQLAYAFGIPTDSANFNLSLDASNAESLDPFVTAAHEHGVQVTLSVGGWTGSLHLSYAVANAQNRTTFVKTLVDFVVKHKLDGLDVDWQSPNKLGLPCNAINANDTANLLLFLQELRKDPVGAKMILSATGNIVPWTDANGNPSADVSAFGKVLDHVTPLLYDVWGSWSDSVGPNSPLNDTCAAPDKQQGSVVSAVAKWNKAGIPLEKIVLGVGAYGHAFSVNKTKAYVNGTKELAAYPPFNKDIHPKGDKWDDPAGVDPCGVATPDGGIFTFWGLIEHGYLNEDGSPKRPYRFDNCSRTAYAYNEEEQVMVSFDDAQAFKEKGAFIKSQGLGGFSVWNAGSDHKDILLDAIRSGAGLSK