wanglab/gogpt-training-data huggingface dataset:
Protein: Chromatin modification-related protein EAF6 (Q59QC2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Enhancer of polycomb-like protein 1
- SWR1-complex protein 4
- Histone acetyltransferase
- Chromatin modification-related protein YNG2
- Chromatin modification-related protein EAF3
- Protein AF-9 homolog
- Histone acetyltransferase ESA1
- Chromatin modification-related protein EAF7
- Chromatin modification-related protein EAF1
- NuA3 HAT complex component NTO1
Sequence:
MSTKDTNDVKPTSSKSNEISSSGTATPKKTSSVPAKEDRKDTTKKDIANERTSSSKSKDDSEKYVELKNKLIQQILKKQELTRKLTTLEDSIYQKEIDYFEESPLGNIVKGFENFSKTSGGGGANKRKIVYSEDDHIFSLSSVNYIKSLMKRQGHTSNGGSSKDDFDDYEDSVDPTTASAGSKANSIEKNETPSGSSGTPSRKRKARVLED
Protein: Protein STRICTOSIDINE SYNTHASE-LIKE 8 (AtSSL8) (Strictosidine synthase 5) (AtSS5) (Q9M1J7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Vacuole {ECO:0000250}.
Interaction partners:
- Probable starch synthase 4, chloroplastic/amyloplastic
- starch synthase
- Starch synthase 3, chloroplastic/amyloplastic
- Starch synthase 2, chloroplastic/amyloplastic
- Protein PTST, chloroplastic
- Starch synthase 1, chloroplastic/amyloplastic
- Phosphoglucan phosphatase DSP4, chloroplastic
- 1,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic
- DEAD-box ATP-dependent RNA helicase 9, mitochondrial
- Granule-bound starch synthase 1, chloroplastic/amyloplastic
Sequence:
MPISRRVLTPITAAPVILAVLCFFFWSSIIGPDNLKGTKHVLQDAKTIPLPVDGPESLEFDPQGEGPYVGVTDGRILKWRGEELGWVDFAYTSPHRDNCSSHEVVPSCGRPLGLSFERKTGDLYICDGYFGVMKVGPEGGLAELVVDEAEGRKVMFANQGDIDEEEDIFYFNDSSDTYHFRDVFYVSLSGTKVGRVIRYDMKKKEAKVIMDKLRLPNGLALSKNGSFVVTCESSTNICHRIWVKGPKSGTNEVFATLPGSPDNIRRTPTGDFWVALHCKKNLFTRAVLIHTWVGRFFMNTMKMETVIHFMNGGKPHGIVVKLSGETGEILEILEDSEGKTVKYVSEAYETKDGKLWIGSVYWPAVWVLDTSVYDSI
Protein: Prolyl carboxypeptidase like protein (Serine carboxypeptidase S28 family protein) (Q94CC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine carboxypeptidase-like 26
- Serine carboxypeptidase-like 34
- Serine carboxypeptidase-like 42
- Proteasome subunit alpha type-5-B
- Alpha/beta-Hydrolases superfamily protein
- Alpha/beta-Hydrolases superfamily protein
- Prolyl endopeptidase
- Serine carboxypeptidase-like 46
- Proteasome subunit beta type-2-B
- Proteasome subunit alpha type-5-A
Sequence:
MLSALGFALLSIFAILLSLSTLSNGLLQPRRISHGLTESSKYLTRDELWFNQTLDHYSPSDHREFKQRYYEYLDHLRVPDGPIFMMICGEGPCNGIPNDYITVLAKKFDAGIVSLEHRYYGKSSPFKSLATENLKYLSSKQALFDLAAFRQYYQDSLNVKFNRSGDVENPWFFFGASYSGALSAWFRLKFPHLTCGSLASSAVVRAVYEFPEFDQQIGESAGPECKAALQETNKLLELGLKVNNRAVKALFNATELDVDADFLYLIADAEVMAIQYGNPDKLCVPLVEAQKNRDDLVEAYAKYVREFCVGVFGLSSKTYSRKHLLDTAVTPESADRLWWFQVCTEVAYFQVAPANDSIRSHQINTEYHLDLCKSLFGKGVYPEVDATNLYYGSDRIAATKIIFTNGSQDPWRHASKQTSSPELPSYIVTCHNCGHGSDLRGCPQSPMVIGGDSKNCSSPDAVNKVRQHIVDHMDLWLSECRGGIRSSM
Protein: Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase) (P79282)
Organism: Sus scrofa (Pig)
Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Interaction partners:
- Beta-1,4-galactosyltransferase
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-mannosidase
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B.
- Beta-1,4-galactosyltransferase
- Beta-1,4-galactosyltransferase
- Mannosyl
- Beta-1,4-galactosyltransferase
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
- MGAT4 family member D.
Sequence:
MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHSDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGPASGRVRALEEQFMKAKEQIENYKKQTKNGPGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLSDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLALESHNWRYATGGWETVFRPVSETCTDRSGSSTGHWSGEVKDKNVQVVELPIVDSVHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGAEAAFHPIEEYTVHVEEDFQLLARRMQVDKKRVYLATDDPALLKEAKTKYPSYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQALHPDASANFRSLDDIYYFGGPNAHNQIAIYPHQPRTEGEIPMEPGDIIGVAGNHWDGYPKGVNRKLGRTGLYPSYKVREKIETVKYPTYPEADK
Protein: RNA polymerase II transcriptional coactivator SUB1 (P54000)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in the release of TFIIB from the transcription complex during transcription initiation. Binds to TFIIB and specifically inhibits the formation of the TBP-TFIIB-promoter complexes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-tRNA-processing protein PTA1
- Transcription initiation factor IIB
- DNA topoisomerase 1
- TATA-box-binding protein
- Transcription elongation factor SPT5
- ATP-dependent RNA helicase SUB2
- RNA polymerase II subunit A C-terminal domain phosphatase
- DNA-directed RNA polymerase II subunit RPB3
- mRNA 3'-end-processing protein RNA15
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MSYYNRYRNKRRSDNGGGNLSNSNNNNGGMPSGLSASDAIFDLGKNKRVTVRQFRNINLIDIREYYLDSSTGEMKPGKKGISLTEDLYDELLKHRLNIDEALRRLGSKRPKTKMVRLLSDDEYEDDNNNDSTNNDKDKNGKDKNSPKKRREDKSKASNESHDLEPRSKKKKPAPPTLLPHEENIQNAEREANATLIIPGQAGRKQQEERKQKEKEEAEEAKAKAVAEQEKEAKAKEKIAEPEPEPVPTLQAKKEDIVSNINESKDANSSDEEFAQSLEAEMNKAEDDISEEE
Protein: Zgc:63600 (Q7SY20)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDNIKDGWFTETCTLWPGQAMSLQVEEVLYHKKSKFQDVMVFKSKTYGNVLILDGVIQCTERDEFSYQEMIANLPLCCHPCPKKVLIIGGGDGGVLREVVKHPLVESVVQCEIDEDAINVSKKYLPGMAKGFFSPKLTLHVGDGFEFMKKNQDAFDIIITDSSDPVGPAESLLKESYYQLMKTALCEGGILCCQGECQWLHLELIKEMRTFCKTLFPVVDYAYCTIPTYPSGQIGFMLCSKNSKTNFREPLRELTRDEIESMSLKYYNPEIHRAAFILPEFARKVLSEA
Protein: Uncharacterized protein (Q9TZE4)
Organism: Caenorhabditis elegans
Interaction partners:
- Transmembrane protein 53
- BTB domain-containing protein
- Serine or cysteine protease inhibitor
- Trafficking protein particle complex subunit 11 domain-containing protein
- TUG ubiquitin-like domain-containing protein
- Homogentisate 1,2-dioxygenase
Sequence:
MGKFSNQKKNRVKNKVAVTVKKAQRMKADAKNAKKDGEVDVEMKEEVVRVRGLAVSSLKKLASGELQNVPKVNEKKIIRKTELPVRENKKILDAPTGKRGTTAQYITKKKAKKMYKKMTHDARDKYRKIQAELAGDGEDDEEGEAEVMEQ
Protein: Protein mago nashi homolog 2 (Q96A72)
Organism: Homo sapiens (Human)
Function: Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:30705154}.
Interaction partners:
- Protein CASC3
- RNA-binding protein 8A
- Eukaryotic initiation factor 4A-III
- Partner of Y14 and mago
- Regulator of nonsense transcripts 3A
- Regulator of nonsense transcripts 3B
- Protein mago nashi homolog
- Small nuclear ribonucleoprotein E
- Pre-mRNA-splicing factor CWC22 homolog
- Small nuclear ribonucleoprotein F
Sequence:
MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
Protein: L-asparaginase 2-1 (EC 3.5.1.1) (L-asparaginase II) (L-asparagine amidohydrolase II) (ASP II) (P0CZ17)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Secreted. Periplasm.
Interaction partners:
- Aspartate aminotransferase, cytoplasmic
- Asparagine synthetase 2
- Asparagine synthetase 1
- Multifunctional protein URA2
- Aspartate aminotransferase, mitochondrial
- Argininosuccinate synthase
- L-asparaginase 1
- Adenylosuccinate synthetase
- Transcriptional regulator URE2
- Nitrogen regulatory protein GLN3
Sequence:
MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
Protein: Cruzioseptin-13 (CZS-13) (C0HK09)
Organism: Cruziohyla calcarifer (Splendid leaf frog) (Agalychnis calcarifer)
Function: Has antimicrobial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:27321580}.
Interaction partners:
Sequence:
GFLDVVHVGKAVGKAALNAVNDLVN
Protein: Ethylene-responsive element binding factor (Ethylene-responsive transcription factor ERF106-like) (Q5YLQ7)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPATFEESTTLEFIRQHLLGDFATVDAFINTLDFGLSHLQPQSHQLPEIFTHGVEPAPITKEPFCEEKRHYRGVRRRPWGKFAAEIRDPNRKGIRVWLGTYDSDVDAAKAYDCAAFKMRGQKAILNFPLEAGEGSQPPAVTTGRKRRREKRVWLPESDITSPGSSEMAWEVKEEEGELDDDDRNGLSLLTRKRVIVTC
Protein: Corrinoid adenosyltransferase MMAB (EC 2.5.1.-) (ATP:co(I)rrinoid adenosyltransferase MMAB) (Methylmalonic aciduria type B protein) (Q96EY8)
Organism: Homo sapiens (Human)
Function: Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable).
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Methylmalonic aciduria type A protein, mitochondrial
- Cobalamin trafficking protein CblD
- Methylmalonyl-CoA mutase, mitochondrial
- Lysosomal cobalamin transport escort protein LMBD1
- Cyanocobalamin reductase / alkylcobalamin dealkylase
- Methionine synthase reductase
- CD320 antigen
- Methionine synthase
- Iodotyrosine deiodinase 1
- E3 ubiquitin-protein ligase CBL
Sequence:
MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTLARYAAMKEGNQEKIYMKNDPSAESEGL
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (M0R7E7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGGAYVAPSVGVRRCPVWLWRRPPRTLGTVASVSPVAHRLPPLPATSNHERARPRCSLLSSRLVLSSATVRSMESPAASPPASLPQTKGKSKRKRDLRISCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Protein: MsrB domain-containing protein (Q38CG0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHPEIEALKRRNRAAGKRLVPIEPDHTNRQSRSTSCSVRRNGSISSLTARTPQSLEQSAERVHEERRQVSSLTSRFTATAPISVNKSYNNRNDGMYTVANGRMGQKPQLSIPRVPARPPVGVRGKTRNNLGSFVRTPTNGEDPVACVSGPAVANVSKVGNKISPEMCHMPSSGGLSSTSVHPAEKDVIEEEYRQHVEESLNDGDEVSSLGGHLAKHEFKSVPDHIRRMLEGDRIEEPYTTKLWEQINTDEGRRTNGYYECIRCGMPLVSPKHQIRFFTRGIAAFSLMHWDGVEVRVGGVASSNNKSKSRGTSEALQLQVRCKCCSGFVGILVPDPEGEPRNIFVVNSCCLSYVKDKTTRCKLSKPCGAHGDDGDGSGMKRLNSRNSRASEGDVEIDFNDPDIFEID
Protein: Two-component response regulator-like APRR7 (Pseudo-response regulator 7) (Q93WK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357, ECO:0000269|PubMed:14563930}.
Interaction partners:
- Protein CCA1
- Protein LHY
- Protein GIGANTEA
- Transcription factor LUX
- Protein EARLY FLOWERING 4
- Protein EARLY FLOWERING 3
- Adagio protein 1
- Protein REVEILLE 8
- Adagio protein 3
- Transcription factor PIF3
Sequence:
MNANEEGEGSRYPITDRKTGETKFDRVESRTEKHSEEEKTNGITMDVRNGSSGGLQIPLSQQTAATVCWERFLHVRTIRVLLVENDDCTRYIVTALLRNCSYEVVEASNGIQAWKVLEDLNNHIDIVLTEVIMPYLSGIGLLCKILNHKSRRNIPVIMMSSHDSMGLVFKCLSKGAVDFLVKPIRKNELKILWQHVWRRCQSSSGSGSESGTHQTQKSVKSKSIKKSDQDSGSSDENENGSIGLNASDGSSDGSGAQSSWTKKAVDVDDSPRAVSLWDRVDSTCAQVVHSNPEFPSNQLVAPPAEKETQEHDDKFEDVTMGRDLEISIRRNCDLALEPKDEPLSKTTGIMRQDNSFEKSSSKWKMKVGKGPLDLSSESPSSKQMHEDGGSSFKAMSSHLQDNREPEAPNTHLKTLDTNEASVKISEELMHVEHSSKRHRGTKDDGTLVRDDRNVLRRSEGSAFSRYNPASNANKISGGNLGSTSLQDNNSQDLIKKTEAAYDCHSNMNESLPHNHRSHVGSNNFDMSSTTENNAFTKPGAPKVSSAGSSSVKHSSFQPLPCDHHNNHASYNLVHVAERKKLPPQCGSSNVYNETIEGNNNTVNYSVNGSVSGSGHGSNGPYGSSNGMNAGGMNMGSDNGAGKNGNGDGSGSGSGSGSGNLADENKISQREAALTKFRQKRKERCFRKKVRYQSRKKLAEQRPRVRGQFVRKTAAATDDNDIKNIEDS
Protein: Cell division protein FtsY homolog, chloroplastic (Chloroplast SRP receptor homolog, alpha subunit CpFtsY) (Fused signal recognition particle receptor) (O80842)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Signal recognition particle receptor protein. Binds GTP specifically. The GTPase activity is inhibited by the N-terminus of the protein until binding to the thylakoid membrane. Activates the GTPase activity of FFC/cpSRP54 when bound to the cpSRP complex. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids. Might be also functionally linked to the Sec translocation machinery.
Subcellular location: Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=The membrane-binding domain is capable of partial insertion into the lipid bilayer.
Interaction partners:
- Signal recognition particle subunit SRP54, chloroplastic
- Inner membrane protein ALBINO3
- Signal recognition particle 14 kDa protein
- Signal recognition particle 9 kDa protein
- Signal recognition particle 43 kDa protein, chloroplastic
- Signal recognition particle 19 kDa protein
- Preprotein translocase subunit SCY1, chloroplastic
- Signal recognition particle subunit SRP68
- AT4g30600/F17I23_60
- Sec-independent protein translocase protein TATA, chloroplastic
Sequence:
MATSSAHLSFLAGRISPFSSERIGLFPLRGEFRPRMTRFRCSAGPSGFFTRLGRLIKEKAKSDVEKVFSGFSKTRENLAVIDELLLFWNLAETDRVLDELEEALLVSDFGPKITVRIVERLREDIMSGKLKSGSEIKDALKESVLEMLAKKNSKTELQLGFRKPAVIMIVGVNGGGKTTSLGKLAHRLKNEGTKVLMAAGDTFRAAASDQLEIWAERTGCEIVVAEGDKAKAATVLSKAVKRGKEEGYDVVLCDTSGRLHTNYSLMEELIACKKAVGKIVSGAPNEILLVLDGNTGLNMLPQAREFNEVVGITGLILTKLDGSARGGCVVSVVEELGIPVKFIGVGEAVEDLQPFDPEAFVNAIFS
Protein: Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase) (P27786)
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05093}. Microsome membrane {ECO:0000250|UniProtKB:P05093}.
Interaction partners:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- 17-beta-hydroxysteroid dehydrogenase type 3
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6
- Aromatase
- Estradiol 17-beta-dehydrogenase 2
- 17-beta-hydroxysteroid dehydrogenase type 6
- Cholesterol side-chain cleavage enzyme, mitochondrial
Sequence:
MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLPRRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST
Protein: Ribonucleoside-diphosphate reductase large chain 2 (EC 1.17.4.1) (Ribonucleotide reductase DNA damage-inducible regulatory subunit 2) (Ribonucleotide reductase R1 subunit 2) (Ribonucleotide reductase large subunit 2) (P21672)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12732713}.
Interaction partners:
- Ribonucleoside-diphosphate reductase small chain 2
- Ribonucleoside-diphosphate reductase small chain 1
- Ribonucleoside-diphosphate reductase large chain 1
- Nucleoside diphosphate kinase
- Thymidylate kinase
- Guanylate kinase
- Adenylate kinase isoenzyme 6 homolog FAP7
- Uridylate kinase
- GTP:AMP phosphotransferase, mitochondrial
- Adenylate kinase
Sequence:
MYVIKRDGRKEPVQFDKITSRITRLSYGLDPNRIDAVKVTQRIISGVYSGVTTVELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVIEDLHDWINPATGKHAPMISDEIYNIVMENKDTLNSAIVYDRDFQYTYFGFKTLERSYLLRLNGEVAERPQHLVMRVALGIHGSDIESVLKTYNLMSLRYFTHASPTLFNAGTPHPQMSSCFLIAMKDDSIEGIYDTLKECAMISKTAGGVGLHINNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALFLEPWHADIFDFVDIRKTHGKEEIRARDLFPALWIPDLFMKRVQEDGPWTLFSPSAAPGLDDVWGDEFEELYTRYEREGRGKTIKAQKLWYAILQAQTETGTPFMVYKDACNRKTNQQNLGTIKSSNLCCEIVEYSSPDETAVCNLASIALPAFVEVSEDGKTASYNFERLHEIAKVITHNLNRVIDRNYYPVPEARNSNMKHRPIALGVQGLADTYMMLRLPFESEEAQTLNKQIFETIYHATLEASCELAQKEGKYSTFEGSPASKGILQFDMWNAKPFGMWDWETLRKDIVKHGLRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDDSMKQYLITQNGSIQGLPNVPQELKELYKTVWEISQKTIINMAADRAIYIDQSHSLNLFLQAPSMGKITSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQEVADQAATHIASVSELDRPVYVPKGTKFSEQKAASALTESSDNEKDASPVPSEQSSVSSAMSNVKLEDSVAPAVPTETIKEDSDEKKCDIYNEKVIACTAPTPEACESCSG
Protein: DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) (A5PJW8)
Organism: Bos taurus (Bovine)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P30876}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
Sequence:
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Protein: Ectopic P granules protein 3 (Q9XWU8)
Organism: Caenorhabditis elegans
Function: Involved in autophagy. Thought to act in autophagasome and omegasome formation.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:20550938}.
Interaction partners:
- Beclin homolog
- Autophagy-related protein 13 homolog
- Ectopic P granules protein 4
- Ectopic P granules protein 5
- Ubiquitin-like protein atg-12
- Autophagy-related protein 9
- Autophagy-related protein 5
- Ectopic P granules protein 2
- Autophagy-related protein 18
- Autophagy-related protein 2
Sequence:
MAKKQKKSTEKSERTVEFKEPPKPANSEERLKPAGRGMKPSPSQNTLNRMERETIVFWRRPHIVIPYALMEIAHLAVELFFKILAHKTVLLLTAISIGLAVYGYHAPGAHQEHVQTIEKHILWWSWWVLLGVLSSIGLGSGLHTFLIYLGPHIAAVTMAAYECQSLDFPQPPYPESIQCPSTKSSIAVTFWQIVAKVRVESLLWGAGTALGELPPYFMARAARISGQEPDDEEYREFLELMNADKESDADQKLSIVERAKSWVEHNIHRLGFPGILLFASIPNPLFDLAGITCGHFLVPFWSFFGATLIGKALVKMHVQMGFVILAFSDHHAENFVKILEKIPAVGPYIRQPISDLLEKQRKALHKTPGEHSEQSTSYLAWGLSLMVTFMILFFFLSIVNSLAKDYHKRLWERKRRQNKDLIDEENQSFEEEEEEAVTPPSSCPLLLSDGFEGVVVKK
Protein: Cycloartenol-C-24-methyltransferase (EC 2.1.1.41) (24-sterol C-methyltransferase 1) (Sterol C-methyltransferase 1) (Protein CEPHALOPOD) (Protein STEROL METHYLTRANSFERASE 1) (Q9LM02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol.
Interaction partners:
- Cycloartenol synthase
- Probable 3-beta-hydroxysteroid-Delta
- Delta
- Methylsterol monooxygenase 1-2
- Methylsterol monooxygenase 1-1
- Methylsterol monooxygenase 1-3
- Sterol 14-demethylase
- Delta
- 7-dehydrocholesterol reductase
- Cycloeucalenol cycloisomerase
Sequence:
MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGWGESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALKQAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE