wanglab/gogpt-training-data huggingface dataset:
Protein: Tequila, isoform F (EC 3.4.21.-) (E1JI93)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMAKWLLGLWLAILLVDRPGAKAYRSGSGYHSEQSEPVGLSATGNAHSSYGGDQQQPIYHRDSACPPHFTGLVAYPHDCHRYVNCFDGSPTIQTCSPGTLFNDRTQVCDHPSNVVCPSAESASTRLGRLRQLDSEPKCQPGVNGLQPHPSDCSKFLNCANGQAFIMDCAPGTAFSPASLVCVHKDLAKCGSGTGAVRDDTSGTGYPALPFDDLGCPPGTRGLRPHPHDVHKYLRCGIGVKPQVEQCPRGHIFDGSSSVCVYSDSPRTSSSSFTSAEIQVNYLLCPVGAVGQFVHPFDQTKFLSCKDGKSAVQNCQPNYVFSISRRYCQLKAQLAFTDYVTLIISEISYEYSLILNACPGNINGIFLYPYDAKKYVQCSSGGRMSILSCGPQMAFSVSQRSCLPSHQVHISDRVQFWQEVQVQTTYTSQDLRGNVQSQLSSLRSCPPNVQKNYPYPFHAGHYVRCQYGALEIICCPTGQLYSLSQRQCVPRSLLSAHDYLDYSYISAELSTEFMVDRSTLSCPPQAQGLYLHPFDCTKYVRCWNQQTFIESCTPGEIFSFSNQKCVPKEQCKGPTDHVEYLIETTTVTTYDSDGPESASSLAKTGDISCPPGASGNHAHPFDCTKFLECSNGQTFVKNCGPGTAFSTAKHICDHANQVDCSGRNSLPEQSQVTQNNIATSYPTKPLDILPILKTSPPSYPHAEHLTDLLCPSGVNGQFVHPFDQTKFLLCQAGKLAVQSCQSGYVFSISKSICQPKTQLVYSDYVTYKVSVISIDQTMILSACPDGTNGLHLYPYDAGKYVRCSDGGKMSIQSCENQMAFSLSQRACRPSRLLSTEDRVRFREELQIQTTYSSQDIQIQQSPLKECPSVLRGNYPYPFHAGHFVNCQNGHLQIVSCPPTALYSLSQRECVVRQLLSPHDYLDYAYISVQLSTNIIHDTTALSCPPQAQGYYLHPFDCTKYIVCWEKQTHIESCPQGEAFSISQQKCVARDKITQAYDRVEYLEDTQHELSHEEAEEEEQTEPESNLSLDGGNQPPGKYQAPYYSNGGYPTPSQNNGGYQTPSQNNGGYQAPFQNNGGYQPSYQGNGGYTPTYQNPFEGYHQPNQSSYQTNGGYQPPLPPHGGYQPPSQTYGGFQQPNRTYEDFHNPSQTVGGFQPPYSVKGGYQPHNQLNGGYNQPNQSSSFQANGGYQPPSQVNRGYQTSFESNGGYQPPLETNKGHQVPSQINGGYQPRVDGNRGYQPPNELNGGYQPPNELNGAYPAPSQLNGGYQPPLEGNLGYRPLSQQNSGYQPPQPSTGGYQPPFQSTGSGHYPGQDAPYAIPTPLLCPEKISGLFPNPFDATGYLTCIDGHTLPRQCQPLDVFSVSQGYCLPEQHVNKTDRVPFERTQTYQDNSLDCPRDFLGFVVYPFDCSKYLSCGPSGMKLLNCPGEQHYSISHGFCKPVDQVQREDRLYTINELHIIFEWTQKMMIVGAVTACPEGITGTLPHPRVPTKYLRCGPGQAEMYDCPSQQIFSVSRRVCVLDDKLSSYDRTDYLVRGVNSGWMDPSNDNRQSKSYETSGRDQFGNRYTTRTTTTTRVIGDRWTDMNMQRPSGVGVEQNPHHHHHGYNPGWSGQETSYVQRGPTQSTLYVEGSLQPNHARETSRTEQTLDPSTTYASTNFQRSTRRAELDPDTLTATTMKTNWHAPGHSRDYHRRHPNLPDPFTEHHPNSSPHQHHHHHRHPHEHSADFHIRHPELPNPFPLKNETPQHQDLNDDWDLLPNSNAEEVTPKLATRSSFNTQCDFDCGNGQCLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAKIEKNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQRYSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQRGRHPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCLYGSPKGAYFVRVGDHYANIAESSEVDSFIENWYLHENFRKGTHMNNDIALVVLKTPLKFSDYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMDESVDACEGDSGGPLVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYEKINESLLRF
Protein: Small ribosomal subunit protein eS17B (40S ribosomal protein S17-B) (Q9P7J6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS4B
- Small ribosomal subunit protein uS2A
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS7
- Elongation factor 3
- mRNA export factor elf1
Sequence:
MGRVRTKTTKRASRVVIEKYYPRLTLDFQTNKRIVDEVAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSELEKDKINVDQDTKDMLKALGYDSIPTVVVAASRPERPFRYRH
Protein: Signal peptidase subunit 3 (Q5AL47)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
- Signal peptidase complex catalytic subunit SEC11
- Signal peptidase complex subunit 2
- Mitochondrial inner membrane protease subunit
- Mitochondrial inner membrane protease subunit
- Signal recognition particle SEC65 subunit
Sequence:
MFNLVTRAQAAANSAFTSSIVITSVVIVLTLLQLYKDNVWSLNTTSITNIRPTASIKQSFHYGSLNRKPKENAKIQFDLSSDLTPLFNWNTKQIFIYLTAEYPGKSEGSSNKVTFWDKIITNKEDANLTLTNQRGKYSVWDVEKSFRGRNATVRLEWNIQPYVGPLIFGSTEGFGEFQFADTQKKKESTKNT
Protein: Glucanase (EC 3.2.1.-) (Q79G13)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable beta-glucosidase BglS
- Probable cellulase Cel12b
- Possible beta-1,3-glucanase
- Probable cellulase CelA2a
- Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Sequence:
MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVMSSAIGSVARWIVPLLGVAAVASIGVIADPVRVVRAPALILVDAANPLAGKPFYVDPASAAMVAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLTLYGIPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQRQERFDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVSNFYTTDEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTATAGAHADAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ
Protein: Small ribosomal subunit protein eS4B (40S ribosomal protein S4-B) (Q9USW5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS8B
- Elongation factor 3
- mRNA export factor elf1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein uS14
Sequence:
MVRGPKKHLKRVAAPHHWLLDKLSGTYAPKPSPGPHKARECLPLIVFLRNRLKYALNGREVKAILMQRLIQVDGKVRTDSTFPTGFMDVISVEKTGEHFRLVYDIKGRFTVHRITAEEAKYKLCKVKRVQLGAKGVPFLVTHDGRTIRYPDPLIKVNDTIKLNLETNKIESFIKFDTSAQVMVTGGRNMGRVGTIVHREHHLGSFEIIHVKDALDREFATRLSNVFVIGEAGKSWISLPKGKGVKLSITEERDRRRALKGLA
Protein: Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)] (Q9NZB8)
Organism: Homo sapiens (Human)
Function: Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
Interaction partners:
- Molybdopterin synthase catalytic subunit
- Gephyrin
- Sulfite oxidase, mitochondrial
- Aldehyde oxidase
- GTP cyclohydrolase 1
- Mitochondrial amidoxime reducing component 2
- Adenylyltransferase and sulfurtransferase MOCS3
- Guanylyl cyclase C
- Retinal guanylyl cyclase 1
- Atrial natriuretic peptide receptor 1
Sequence:
MAARPLSRMLRRLLRSSARSCSSGAPVTQPCPGESARAASEEVSRRRQFLREHAAPFSAFLTDSFGRQHSYLRISLTEKCNLRCQYCMPEEGVPLTPKANLLTTEEILTLARLFVKEGIDKIRLTGGEPLIRPDVVDIVAQLQRLEGLRTIGVTTNGINLARLLPQLQKAGLSAINISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYNPVKVNCVVMRGLNEDELLDFAALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTAKAFKIPGFQGQISFITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLRDHLRAGASEQELLRIIGAAVGRKKRQHAGMFSISQMKNRPMILIELFLMFPNSPPANPSIFSWDPLHVQGLRPRMSFSSQVATLWKGCRVPQTPPLAQQRLGSGSFQRHYTSRADSDANSKCLSPGSWASAAPSGPQLTSEQLTHVDSEGRAAMVDVGRKPDTERVAVASAVVLLGPVAFKLVQQNQLKKGDALVVAQLAGVQAAKVTSQLIPLCHHVALSHIQVQLELDSTRHAVKIQASCRARGPTGVEMEALTSAAVAALTLYDMCKAVSRDIVLEEIKLISKTGGQRGDFHRA
Protein: Transcription factor HES-7 (hHes7) (Class B basic helix-loop-helix protein 37) (bHLHb37) (Hairy and enhancer of split 7) (bHLH factor Hes7) (Q9BYE0)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFSALHGYLRPKPPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLCSPRAGDSGAPAPLTGLLPPPPPPHRQDGAPKAPLPPPPAFWRPWP
Protein: RuBisCO chaperone RbcX (Q31N04)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: An RbcL-specific chaperone. The central cleft of the RbcX homodimer (RbcX2) binds the C-terminus of an RbcL monomer, stabilizing the C-terminus and probably preventing its reassociation with chaperonin GroEL-ES. At the same time the peripheral region of RbcX2 binds a second RbcL monomer, bridging the RbcL homodimers in the correct orientation. The RbcX2(2)-bound RbcL dimers then assemble into the RbcL8 core (RbcL8-(RbcX2)8). RbcS binding triggers the release of RbcX2.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00855, ECO:0000269|PubMed:30389782, ECO:0000269|PubMed:31048338}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00855, ECO:0000269|PubMed:30389782}. Note=Most protein is cytoplasmic, but some is in the carboxysome. {ECO:0000255|HAMAP-Rule:MF_00855}.
Interaction partners:
- RuBisCO accumulation factor 1
- Carboxysome assembly protein CcmN
- Carboxysome assembly protein CcmM
- Ribulose bisphosphate carboxylase large chain
- CO2 hydration protein
- DUF2973 domain-containing protein
- Mo-dependent nitrogenase C-terminal domain-containing protein
- DUF1830 domain-containing protein
- TIGR02652 family protein
- Uncharacterized protein
Sequence:
MASTQRAKPMEMPRISRDTARMLVNYLTYQAVCVIRDQLAETNPAGAYRLQVFSAEFSFQDGEAYLAALLNHDRELGLRVMTVREHLAEHILDYLPEMTIAQIQEANINHRRALLERLTGLGAEPSLPETEVSDRPSDSATPDDASNASHAD
Protein: 11-beta-hydroxysteroid dehydrogenase B (EC 1.1.1.146) (17-beta-hydroxysteroid dehydrogenase B) (EC 1.1.1.-) (Steroleosin-B) (A7LB59)
Organism: Arachis hypogaea (Peanut)
Function: Has dehydrogenase activity against 11 beta-hydroxysteroid and 17 beta-hydroxysteroid. May be involved in signal transduction regulated by various sterols.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:25860789}. Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000305}. Note=Surface of oil bodies. Exists at a monolayer lipid/water interface. {ECO:0000305}.
Interaction partners:
Sequence:
MDLINSVLNLFVPPASLITLAFSWPALCFPHACEWLYNTVYGDNMDGKVVIITGASSGIGEQIAYEYALRRACLVLVARREHRLRGIAENARRMGARHVMIVAADVVKEDECRRFVNETINFYGRVDHLVNTVSLGHTFYFEEVTDTSVFPVLLDINFWGNIYPTLVALPYLHRTNGRVIINASVESWLPLPRMSLYAAAKAALVNFYETLRFELRDEVGVTIATHGWIGSEMTSGKFMLEEGAEMQWKEEREMNVIGGPVEEFARLMVAGACRGDAYVKYPSWYDVFLLYRVFAPNVLNWAFRLLIAPQGTKRTSSYVGTGRSLEGRPMLEAPSPRTALLAPYSFSGGGQLS
Protein: Copper-transporting ATPase (O26033)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236, ECO:0000256|RuleBase:RU362081}. Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- COP-associated protein
- Riboflavin biosynthesis protein RibD
- Sodium/glutamate symporter
- Methyltransferase small domain-containing protein
Sequence:
MKCSHCQLEFKESELFKEVINHKELHFCCTGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMSALELEQALEENNKGDFILNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQKEQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQTEKHPKDVAIGSVVWVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSANFQNSRLSGLLETLKKSFLEKPLIESSANQIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKVREHLAHSAILKSLDGDEVSLEKIEFFAHGLKASYQNETLLVGSLKFLGSMGVDIPMKESANIMVGFAKNETLCALFILEERLKANAKEVVQALQNKGLELEILSGDNESSVKECAKKLGISNYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A0A8I6ARJ1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMTTVCSLLCLKYRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFGKHIGELYSNSQHGFSGDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPTENTEEYGNIIVTLKSTEVHACYTVRRFSVRNTKVKKGQKGNPKGRQNERTVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSSQLHSYVNSILIPGVGGKTRLEKQFKLITQCNAKYVECFSAQKECNKEKNRNSSVVPAERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALARDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFVYKAMLSLVSTKENGNGPMTGDKNGAVLTAEESDPAESMESLV
Protein: dual-specificity kinase (EC 2.7.12.1) (Q9VE06)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH23568p
- Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog
Sequence:
MSLNQHSGPGPPSEICGLSVDQVDSSAASPFIWPSTAGMCTTATTVTTSTNGDATAEAPVKHQPLHNGGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDFVKEKIGSGFFSEVYKVTHRTTGQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGDFGLAAKIPVKSRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAFVELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEHESSAGASPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDEDGFRFPSKKSASAALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTSPSDKARCHQMQRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPVPAVLTLRKVGDPQYKPTSEKDHNGSKPNPFEALAQLRGVKKILDANPKTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATPSEPKSLPVSPHMTRKYSAIELRLPQRISNAAPPAVTSAPPPSIALPTDEDDCDDCNSEGEDPDGGGNCADAESSSDDSAVRPSTVPTARKYRANSLYAHPLFRGSNGTSMKSTSTGEFESPTLLKASASTITLTASVGATNSCEDLTESARKSKEQASSGATAAVQALPTPMSGCSTRLVETPVSVSSCTDLELDELKNTCDLNELKNSCEQLPLKTNLTRRDSIESGFFSCFNEESDAAITNNSFGRQLNGIGSLGFGCGGGGNSSNCCYEKLKTQLMLDACVSADSEINDKLASLCRCCYYATSTSNAAVTAAAAAAQQQQQSHLLNDTSSTSSSVLLIDNDPAVIGGNTSSSTALDSMDDLDADIVASRRTHQRRYTCHHALLSGNGSESQMAATASLINRLALDSEIHTLLQRSPFATNQLLYCKNRTSSIYTDSSDDISSLAGSDSLLWDDRSFTALPSTRSAQIAKIVEYFERKRQDSSPPSVHHRNGNGTVAAAVAASALGSNYLSYESRRYSDFKRHLNADGLCFDLDKKPAQQRMMVCEGAVKSKLPIFDKKKQQQGG
Protein: ZIC family member 2 (Odd-paired homolog, Drosophila) B (Zinc finger protein ZIC 2b) (Zinc finger protein Zic2) (Q9DE40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Homeobox protein TGIF1
- EPH receptor B1.
- Sine oculis homeobox homolog 3a.
- Six3
- Sonic hedgehog protein
Sequence:
MLLDAGHQISGLGVGTFTRHHSAVSETQDRDMSFMESAHMGAFKLNHPDLSPGQSAAFAPQASSYSAAALGAHAAAHAASFASSTFNSTREFLLRSRGFGDSTPASGQHPIFSSTSGSLHHSHPEGQGHLLFPGIHEQHGSHHGSPNILNGRLGLPGEVFGRTEQYHQVPNTRADPYSQYGLNMSMNMAHHPGAFFRYMRQQCIKQELICKWIDPEQLGDPKKCCSKTFSTMHELVTHVSTEHVGGPEQCNHICFWEECPRESKPFKAKYKLVNHIRVHTGEKPFACPFPGCGKVFARSENLKIHKRTHTGEKPFLCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKLCDKSYTHPSSLRKHMKVHEDQAPIADSSPAGSSGYESSTPSSLISPCSETHSTLSPDSAALNSSGHNSLTSNFNEWYV
Protein: Vomeronasal type-1 receptor 44 (Vomeronasal type-1 receptor A10) (Vomeronasal type-1 receptor B11) (Vomeronasal type-1 receptor B4) (Q9EQ47)
Organism: Mus musculus (Mouse)
Function: Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vomeronasal type-1 receptor 43
- Olfactory receptor
Sequence:
MNKANLLHIDTNIKITLLAEVSVGISANSILFIAYLCMLLGENRHKPIDLYIAFLSLTQLMLLITMGLIAVDMFMPWGRWDSTTCQSLIYLHRFLRGLTLCATCLLNVLWTITLSSRNSCLAKFKHKYPHHISGAFLFLCVLYMSFSSHFLVSMTVTPNLTSENFMYVTQSCSLLPMSYSRTSMFSTPVAIRETFLISLMALSSGYMVALLWRHKKQAQHLRSTSLSSKASPEQRATRTILLLMSFFVVFYILDTVIFHSRMKFKDGSILYCFQIIVSHSYVTVSPFVFICTEKHIIKFLRSMCGRIANI
Protein: Uncharacterized protein C29A4.14c (O14017)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein C17C9.14
- Peroxisomal biogenesis factor 11
- Peroxisome assembly protein 12
- Peroxisomal membrane protein pex13
- Peroxisomal membrane protein pex14
- Mitochondrial fission 1 protein
- Inactive metallocarboxypeptidase ecm14
- Dol-P-Man:Man
Sequence:
MLKSFEKHLNAVSRKCCNFILGSSIPVLGFYCADTCIRNAFMEFMETRNSKSKYVEAFNTVQSNGATSAISTFHILKDEIIRRIPLLPIIQELRETRMSEVSAEEKILLWNQLKFMSLVRMFTTLAVLAQCNLLCKLALTVLGREAFKEQMVKEFDPSNTLRPSGSDEDPAVFTGIAYILLNNQLDELIQQVQLAVTLTFEEVSPTDIVDRKLIEALTTRVVEVFVNNYQFSIDGNKEVLLAEIPKQYIVTGNLLYRVLELEDFATQMDASIVMKNELIALNEHMLTYLPSIPQEGIRLAKILTTFTKISENVFEAPFQEQFFQSLQMVSDVNRYMAIVFSSFDDC
Protein: Protein NLRC3 (Q5DU56)
Organism: Mus musculus (Mouse)
Function: Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination. Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells. May also affect NOD1- or NOD2-mediated NF-kappa-B activation (By similarity). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7RTR2}.
Interaction partners:
- Caspase-1
Sequence:
MRRRYSHDPPGSFRETKVFGFRGEYGCKALVDLLAGKGSQLLQVRDKMPDSPLGSQSNESRIPKHSEALLSRVGNDPELGSPSHRLASLMLVEGLTDLQLKEHDFTQVEATRGVWHPARVITLDRLFLPLSRVSIPPRVSLTIGVAGVGKTTLVRHFVHCWARGQVGKGFSRVLPLTFRDLNTYEKLSADRLIQSIFSSIGEASLVATAPDRVLLVLDGLDECKTPLEFSNTMACSDPKKEIQVDHLITNIIRGNLFPEISVWITSRPSAAGQIPGGLVDRMTEIRGLTEEEIKVCLEQMFPEEQNLLGQVLSQVQANRALYLMCTVPAFCRLTGLALGHLYRTRLAVQDIELPLPQTLCELYSWYFRMALGGEGQDKEKVSPRIKQVTQGARKMVGTLGRLAFHGLVKKKYVFYEQDMKAFGVDLALLQNTLCSCLLQREETLASSVAYCFIHLSLQEFVAATYYYSASKRAIFDLFTESGMSWPRLGFLAHFRCAAQRATQAKDGRLDVFLRFLSGLLSPRVNTLLAGSLLSQGEHQSYRDQVAEVLQGFLHPDAAVCARAINVLYCLSELRHTELACSVEEAMRSGTLAGMTSPSHRTALAYLLQMSDICSPEADFSLCLSQHVLQSLLPQLLYCQSLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNRTLEILDLRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMISEAIKTNAPTCTVEI
Protein: Drosophila multidendritic neurons sodium channel 1 (O44940)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAEIREDEEEKKSGISILPGPELLALPGFDTRASIASAALSDVPSDVIIKSRIRYGSPLSACKGLLLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLKWQESPVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARMAVAMHICDSEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGPFCKWNGRFYFCDKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKDINCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSRLSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCMRICGSCRDRRKHKIQQQNSVDLPEENSEN
Protein: Hsf (Q4KTX9)
Organism: Haemophilus influenzae
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}. Cell surface {ECO:0000256|ARBA:ARBA00004241}.
Interaction partners:
Sequence:
MNKIFNVIWNVMTQTWVVVSELTRTHTKRASATVETAVLATLLFATVQANATDEDEELDPVVRTAPVLSFHSDKEGTGEKEVTENSNWGIYFDNKGVLKAGAITLKAGDNLKIKQNTDESTNASSFTYSLKKDLTDLTSVATEKLSFGANGDKVDITSDANGLKLAKTGNGNVHLNGLDSTLPDAVTNTGVLSSSSFTPNDVEKTRAATVKDVLNAGWNIKGAKTAGGNVESVDLVSAYNNVEFITGDKNTLDVVLTAKENGKTTEVKFTPKTSVIKEKDGKLFTGKENNDTNKVTSNTATDNTDEGNGLVTAKAVIDAVNKAGWRVKTTTANGQNGDFATVASGTNVTFESGDGTTASVTKDTNGNGITVKYDAKVGDGLKFDSDKKIVADTTALTVTGGKVAEIAKEDDKKKLVNAGDLVTALGNLSWKAKAEADTDGALEGISKDQEVKAGETVTFKAGKNLKVKQDGANFTYSLQDALTGLTSITLGGTTNGGNDAKTVINKDGLTITPAGNGGTTGTNTISVTKDGIKAGNKAITNVASGLRAYDDANFDVLNNSATDLNRHVEDAYKGLLNLNEKNANKQPLVTDSTAATVGDLRKLGWVVSTKNGTKEESNQVKQADEVLFTGAGAATVTSKSENGKHTITVSVAETKADSGLEKDGDTIKLKVDNQNTDNVLTVGNNGTAVTKGGFETVKTGATDADRGKVTVKDATANDADKKVATVKDVATAINSAATFVKTENLTTSIDEDNPTDNGKDDALKAGDTLTFKAGKNLKVKRDGKNITFDLAKNLEVKTAKVSDTLTIGGNTPTGGTTATPKVNITSTADGLNFAKETADASGSKNVYLKGIATTLTEPSAGAKSSHVDLNVDATKKSNAASIEDVLRAGWNIQGNGNNVDYVATYDTVNFTDDSTGTTTVTVTQKADGKGADVKIGAKTSVIKDHNGKLFTGKGLKDANNGATVSEDDGKDTGTGLVTAKTVIDAVNKSGWRVTGEGATAETGATAVNAGNAETVTSGTSVNFKNGNATTATVSKDNGNINVKYDVNVGDGLKIGDDKKIVADTTTLTVTGGKVSVPAGANSVNNNKKLVNAEGLATALNNLSWTAKADKYADGESEGETDQEVKAGDKVTFKAGKNLKVKQSEKDFTYSLQDTLTGLTSITLGGTANGRNDTGTVINKDGLTITLANGAAAGTDASNGNTISVTKDGISAGNKEITNVKSALKTYKDTQNTAGATQPAANTAEVAKQDLVDLTKPATGAAGNGADAKAPDTTAATVGDLRGLGWVLSAKKTADETQDKEFHAAVKNANEVEFVGKNGATVSAKTDNNGKHTVTIDVAEAKVGDGLEKDTDGKIKLKVDNTDGNNLLTVDATKGASVAKGEFNAVTTDATTAQGTNANERGKVVVKGSNGATATETDKKKVATVGDVAKAINDAATFVKVENDDSATIDDSPTDDGANDALKAGDTLTLKAGKNLKVKRDGKNITFALANDLSVKSATVSDKLSLGTNGNKVNITSDTKGLNFAKDSKTGDDANIHLNGIASTLTDTLLNSGATTNLGGNGITDNEKKRAASVKDVLNAGWNVRGVKPASANNQVENIDFVATYDTVDFVSGDKDTTSVTVESKDNGKRTEVKIGAKTSVIKDHNGKLFTGKELKDANNNGVTVTETDGKDEGNGLVTAKAVIDAVNKAGWRVKTTGANGQNDDFATVASGTNVTFADGNGTTAEVTKANDGSIAVKYNVKVADGLKLDGDKIVADTTVLTVADGKVTAPNNGDGKKFVDASGLADALNKLSWTATAGKEGTGEVDPANSAGQEVKAGDKVTFKAGDNLKIKQSGKDFTYSLKKELKDLTSVEFKDANGGTGSESTKITKDGLTITPAHGAGAAGANTANTISVTKDGISAGNKAVTNVVSGLKKFGDGHTLANGTVADFEKHYDNAYKDLTNLDEKGADNNPTVADNTAATVGDLRGLGWVISADKTTGEPNQEYNAQVRNANEVKFKSGNGINVSGKTLNGTRVITFELAKGEVVKSNEFTVKNADGSETNLVKVGDMYYSKEDIDPATSKPMTGKTEKYKVENGKVVSANGSKTEVTLTNKGSGYVTGNQVADAIAKSGFELGLADAAEAEKAFAESAKDKQLSKDKAETVNAHDKVRFANGLNTKVSAATVESTDANGDKVTTTFVKTDVELPLTQIYNTDANGNKIVKKADGKWYELNADGTASNKEVTLGNVDANGKKVVKVTENGADKWYYTSADGAADKTKGEVSNDKVSTDEKHVVRLDPNNQSNGKGVVIDNVANGEISATSTDAINGSQLYAVAKGVTNLAGQVNNLEGKVNKVGKRADAGTASALAASQLPQATMPGKSMVAIAGSSYQGQNGLAIGVSRISDNGKVIIRLSGTTNSQGKTGVAAGVGYQW
Protein: Ribosome assembly factor mrt4 (mRNA turnover protein 4) (Q9USZ6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000250|UniProtKB:P33201}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:P33201}.
Interaction partners:
- Ribosome biogenesis protein rlp24
- Probable nucleolar GTP-binding protein 1
- Ribosome biogenesis protein erb1
- Ribosome biogenesis protein nsa2
- 60S ribosome subunit biogenesis protein nip7
- GTPase grn1
- Ribosome production factor 2 homolog
- 25S rRNA
- Pescadillo homolog
- Probable rRNA-processing protein ebp2
Sequence:
MPKSRRSKVLTLAQTEKKGHEGKAALFSGVQQSLDSFDYMWIFDVTNMRNTYLKRIRDDWKGSRIFMGKTKVMAKALGHTPEEEHAENVSKLTKLLHGAVGLLFTNSKPDEVIGYFESFVQNDFARAGAVAPFTHVIPAGPVYSRAGQIPVEDDILLTHTLEPQVRQLGMPTVLKNGVVTLLADFPLCTEGQQLDSRQTRLLKLFGITAAEFKVGLLGYYSKKGASVEFLQSAPGADEAME
Protein: Zinc finger protein 672 (D6RD56)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFATSGAVAAGKPYSCSECGKSFCYSSVLLRHERAHGGDGRFRCLECGERCARAADLRAHRRTHAGQTL