wanglab/gogpt-training-data huggingface dataset:
Protein: Cold-regulated protein 27 (Q8L8T7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with COR28, involved in central circadian clock regulation and in flowering promotion, by binding to the chromatin of clock-associated evening genes TOC1, PRR5, ELF4 and cold-responsive genes in order to repress their transcription. Negative regulator of freezing tolerance.
Subcellular location: Nucleus {ECO:0000269|PubMed:27990760}.
Interaction partners:
- Histone H4
- Lysine-specific demethylase ELF6
- Two-component response regulator-like APRR1
- Two-component response regulator-like APRR5
- Zinc ion binding / DNA binding protein
- PHD finger family protein / SWIB complex BAF60b domain-containing protein / GYF domain-containing protein
- Transcription factor HY5
- Protein CCA1
- Ubiquitin-ribosomal protein eL40z fusion protein
- Zinc finger protein CONSTANS-LIKE 1
Sequence:
MVGDYRGRFSSRRFSDDSDDSSDDASSVEGETTSSMYSAGKEYMETEWTNEKHSLYLKSMEASFVDQLYNSLGALGKNENVSESTRFGSGRKPSQEQFKVLHDGFWQKINVKQPEHRINGRHGGNSHEFLRSPWIKHYKPLVKTQIPVTDEPENQVVSSSNGKKGICSSGSASSLKQLSSHSRDHDQISVGEAEVSDQNFVNEGIKGENGSSKKMKTVMMSESSSTDQVVPLNKLLQHDVNLKSVS
Protein: Auxin response factor 9 (Q9XED8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin-responsive protein IAA27
- Auxin-responsive protein IAA8
- Auxin-responsive protein IAA29
- Auxin-responsive protein IAA34
- Auxin-responsive protein IAA28
- Auxin-responsive protein IAA17
- Auxin-responsive protein IAA10
- Auxin-responsive protein IAA32
- Auxin-responsive protein IAA30
- Auxin-responsive protein IAA11
Sequence:
MANRGGEYLYDELWKLCAGPLVDVPQAQERVYYFPQGHMEQLEASTQQVDLNTMKPLFVLPPKILCNVMNVSLQAEKDTDEVYAQITLIPVGTEVDEPMSPDPSPPELQRPKVHSFSKVLTASDTSTHGGFSVLRKHATECLPPLDMTQQTPTQELVAEDVHGYQWKFKHIFRGQPRRHLLTTGWSTFVTSKRLVAGDTFVFLRGENGELRVGVRRANLQQSSMPSSVISSHSMHLGVLATARHATQTKTMFIVYYKPRTSQFIISLNKYLEAMSNKFSVGMRFKMRFEGEDSPERRYSGTVIGVKDCSPHWKDSKWRCLEVHWDEPASISRPNKVSPWEIEPFVNSENVPKSVMLKNKRPRQVSEVSALDVGITASNLWSSVLTQPHEFAQSCITSQWSSPQQCHRDANEDAKKSDWLNNSYSVSNVAKDSTLNDQMVSPVEQKKPETTANYRLFGIDLMSSSLAVPEEKTAPMRPINISKPTMDSHSDPKSEISKVSEEKKQEPAEGSPKEVQSKQSSSTRSRTKVQMQGVPVGRAVDLNALKGYNELIDDIEKLFDIKGELRSRNQWEIVFTDDEGDMMLVGDDPWPEFCNMVKRIFIWSKEEVKKMTPGNQLRMLLREVETTLTTTSKTDNHSN
Protein: SELI protein (Selenoprotein I) (Q8WU57)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGCALCVTLPMSLLNFFSVDPLVTFRYFRATS
Protein: Large ribosomal subunit protein eL8 (50S ribosomal protein L7Ae) (Ribonuclease P protein component Rpp38) (RNase P component Rpp38) (EC 3.1.26.5) (Ribosomal protein L8e) (P62426)
Organism: Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
Function: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, this subunit dramatically stimulates RNase P activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00326, ECO:0000269|PubMed:20675586}.
Interaction partners:
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein eL42
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS15
Sequence:
MAVYVKFEISQELEEKTAEVVANAEKIKKGANEVTKAVEKGIAKLVVIAQDVQPEEIVAHIPVICDEKGIAYSYSSTKEALGKAAGLEVPTSAIAVVAEGSADELKDLVEKLNGLKA
Protein: RAB18A, member RAS oncogene family (Ras-related protein Rab-18a) (Q6P129)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
Interaction partners:
- NHL repeat-containing 2.
Sequence:
MNDDILTTLKILIIGESGVGKSSLLLRFTDDTFDAEIGATIGVDFKVKTLAVDGNRAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVSRRETFAKLDNWLSELETYCTRNDLVKMLVGNKIDKDDREIEREEGLKFARKHSMLFIESSAKTRDGVQCAFEELVEKILQTPGLWESMHKSRGVALSELSESSQGGCGAYCSLL
Protein: FC gamma 2 receptor (Q28109)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MAPTLPALLCLGLSVGLRTQVQAGTFPKPIIWAEPSSVVPLGSSVTILCQGPPNTKSFSLNKEGDSTPWNIHPSLEPWDKANFFISNVREQQAGRYHCSHFIGVNWSEPSEPLDLLVAGEEPAGRLRDRPSLSVRPSPSVAPGENVTLLCQSGNRTDTFLLSKEGAAHRPLRLRSQDQDGWYQAEFSLSPVTSAHGGTYRCYRSLSTNPYLLSQPSEPLALLVADYTMQNLIRMGLAASVLLLLGILLCQARHDHGGAREAARS
Protein: Cullin 3, isoform F (FI19425p1) (Q8IP45)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RING-box protein 1B
- Protein roadkill
- FI11917p
- RING-box protein 1A
- Ubiquitin-like protein NEDD8
- AT19737p
- Insomniac, isoform B
- S-phase kinase-associated protein 2
- Cullin-associated NEDD8-dissociated protein 1
- Supernumerary limbs, isoform B
Sequence:
MQGRDPRQQQPEPLNNLNANGRYHNRMVAGSNNFNGATVGNVDSAVPCRIARQNVLGQQARSMNINVPNASSMQQHQQSQNRLSAQGLASASRRSYHLAASGGRVRADNRINTNHPLTPTPLSMPVPAPAAPAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA
Protein: tRNA-dihydrouridine synthase 4, putative (Q583Y8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGVEPEPRARTDLASMLKEAQSAILRLVKEAPELRDATIEPSQYEWACQRMEKAYGSILKIQAPMVRCSRPAFRKLCRLWGTDISYTHMIMADSFACSEAARQAEFSIYSGETRLITQLASSSGPTAATAAAIVAPWCDAIDLNCGCPQRRVMADGLGAALLRNPEVVADTVRCVRNALEGGVELPCVVKMRVKDDVRLSVDFARQCEAAGAAWITVHGRTPNCSAHAPVRFDAINTIREALGVPVVANGGVRDPSTALQAALTAGVGGVMSGMGLLANPACFYVPGADEKFHFEPQHIAYGTGSCPWESGSEVREEHIDARKRCLSTGHSGGERDAKTVWPKGFSHCPLEVLSDFIRLSCVTDLGSKATSMHLLKMGGNYLSPVERTFIAEMHSSFSVIAAFQQLGLYVREGRFQVE
Protein: Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) (P23007)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P00889}.
Interaction partners:
- Malate dehydrogenase
- Aconitate hydratase, mitochondrial
- Cytoplasmic aconitate hydratase
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- ATP-citrate synthase
- Malate dehydrogenase, cytoplasmic
- Acetyltransferase component of pyruvate dehydrogenase complex
- Malic enzyme.
- Fumarate hydratase, mitochondrial
- Malic enzyme
Sequence:
ASSTNLKDVLAALIPKEQARIKTFRQQHGGTALGQITVDMSYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKGGXGGEPLPEGLFWLLVTGQIPTGAQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGILRTKYWEMVYESAMDLIAKLPCVAAKIYRNLYRAGSSIGAIDSKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLGWLAQLQKAXXXAGADASLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPGDPMFKLVAQLYKIVPNVLLEQGAAANPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLIAL
Protein: Steroid C26-monooxygenase (EC 1.14.15.29) (Cholest-4-en-3-one 26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 125) (Steroid C27-monooxygenase) (P9WPP0)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function: Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
Interaction partners:
Sequence:
MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH
Protein: 25S rRNA (adenine(2142)-N(1))-methyltransferase (EC 2.1.1.286) (Base MethylTransferase of 25S RNA) (P38278)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03044, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:23558746}.
Interaction partners:
- 25S rRNA
- Protein-lysine N-methyltransferase EFM2
- Large ribosomal subunit protein uL23
- Eukaryotic translation initiation factor 5B
- Translation initiation factor IF-2, mitochondrial
- Exosome complex exonuclease RRP6
- DNA-directed RNA polymerases I and III subunit RPAC1
- Large ribosomal subunit protein bL17m
- CTP synthase 1
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MHSRKSKSITGKRKQVGSNVTRVIKPQKTRRIIRRFHHLINKRQSICKFLCLKENLDDSNEEKNDKIIRLSIKGNVRLGKYYEDGKSQSFNDAMESQLLRLHSLIKNESKSKDTSDLAVMYTLLGYIMNQINKLGGLETYQIASQNGQLKERGGDTSKLLEKWIRSSFENCPGAVALEIGSLSSGNRISRCALFRNVVRIDLEEHEGVIKQDFMERPLPRNENDKFDLISCSLVLNFVKNHRDRGAMCHRMVKFLKPQGYIFIVLPQACVTHSRYCDKTLLQNLLGSIGLIMLNSHQSNKLYYCLYQLQVVPPQPSSFSKRIKVNDGPGLNNFGITL
Protein: Fatty acyl CoA syntetase 1 (EC 6.2.1.3) (Q38FC0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Long-chain-fatty acid-CoA ligase protein, putative
- Monoglyceride lipase, putative
- Monoglyceride lipase, putative
- Fungal lipase-type domain-containing protein
- Lipase-like protein, putative
Sequence:
MGMYVTKLLSLWSHWFEVDDEVIIARQKFGPLAHICGPAEGENCSPVYRSIGVTDEEQARITREWYYGEHFLKQLEQTCTSRRDTLAVAYRTINKVEKEWREDHNGKRREWQVTHLNDPVYMTYGELWENSVAFGKGLREYGAKEGDRVAIYEDTRWEWLASAIGVWTQLMVTVTVYANLCREGLMHALKETECAAIICNGQNIKDLITLLKEVNLTNTTLVYLDSLPDGLNDEGMRLIPWKQVLETGMKSNLGYTIPGNCDTTALIMYTSGTVAAPKGVMHTFGSLTASKNGLADRFLECIGPKEEGETYVSYLPLAHILEFIADVVMLSRGTLVCFGSPRTLTDDTARPRGDLKEFKPVFIVGVPRIFETIRKVVESRLPPVGSFKRTLFDTAYADRLRALKEGKDTPFWNEKVFKVPRDMFGGRLRGVVCGGAPLADRTQEFMRVVFGLPLGQGYGLTETCCNGSIQRLGELYPSVGQLLKGVEGRLLDTDEYKHTDKPFPRGELCLRGSFMFKGYYKQEAMSKEVLIPGGWFRTGDVVEIGEDNALRVIGRVKALVKNLLGEYIQLEYLEVIYSQHPLSAPNGVCILVNQRRAYICALVITDEERAKKFAQENGIGGTWPEILKDPTFHQRAAKSLSNFGASIGRKPFELLRQVRVIADEWTAKNGMLTVSMKIRRNKVEERYGDVIEQLFKYE
Protein: Thioredoxin-like 1-1, chloroplastic (Atypical cysteine/histidine-rich thioredoxin 4) (AtACHT4) (Lilium-type thioredoxin 1-1) (O64654)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19109414}.
Interaction partners:
- 2-Cys peroxiredoxin BAS1, chloroplastic
- Thioredoxin-like 4, chloroplastic
- NADPH-dependent thioredoxin reductase 3
- Thioredoxin-like 3-1, chloroplastic
- PsbP domain-containing protein 4, chloroplastic
- Protein disulfide-isomerase 5-4
Sequence:
MTEVISKTSLFLGACGNHHRVDDFSFSPVSFGGFGLKKSFSCLKLKSQKPLRSVFYGKQIVFGDSQDESFRRSSAITAQTTLRIGTAQKWWEKGLKDNMREISSAQELVDSLTNAGDKLVVVDFFSPGCGGCKALHPKICQFAEMNPDVQFLQVNYEEHKSMCYSLGVHVLPFFRFYRGSQGRVCSFSCTNATIKKFRDALAKHGPDRCSLGPTKGLEEKELVALAANKELNFTYTPKPVPVEKEAATPDSNPSLPVPLPSMSSNDEKTLVSAGR
Protein: MSTA protein (Q5ASJ3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MADAVIAGQRVEAPVTWKAYLMCVFAAFGGIFFGYDSGYINGVMGMDYFIQEFTGKVKSETPAAQFVISSSNKSLITSILSAGTFFGAIIAGDLADWYGRRITIINGCGVFMAGVAFQIASTTVPMLVVGRLIAGVGVGFVSAIIILYMSEISPRRFRGAIVSGYQFCITIGLMLASCVNYGTENRNDSGSYRIPIALQLLWAIILGIGLFVLPESPRYYVRKNNLAEAAKTLARVRGQPPESEYITQELAEIVANNEYEMQVIPQGGYFATWLNCFRGGLRSPNSNLRRVILGTSLQMMQQWTGVNFVFYFGTTFFQNLGTIDDPFLISMITTIVNVFSTPISFYTMEKLGRRPLLLWGALGMVVCQFIVAIAGTVDGDNSKTVSAQISFICIYIFFFASTWGPGAWVVIGEIFPLPIRSRGVALSTASNWLWNCIIAVITPYMVDIDKGNLKSRVFFIWGSLCACAFVYVYFLIPETKGLTLEQVDKMMEETTPRTSAKWKPHSTFATEMGMTEKNASTTVESAA
Protein: Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (Neuroprotective protein 6) (Thorase) (Q505J9)
Organism: Rattus norvegicus (Rat)
Function: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8NBU5}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000250|UniProtKB:Q8NBU5}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5T0}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- UBX domain-containing protein 7
- UBX domain-containing protein 7
- Peroxisomal membrane protein PEX16
- Acyl-CoA-binding domain-containing protein 5
- Peroxisomal membrane protein PEX14
- Peroxisomal membrane protein 2
- Peroxisomal membrane protein 4
- Peroxisomal membrane protein PEX13
- ATP-binding cassette sub-family D member 1
- Aldehyde dehydrogenase family 3 member A2
Sequence:
MVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQSVLTHVCLD
Protein: Protein-arginine N-acetylglucosaminyltransferase NleB1 (Arginine GlcNAcyltransferase NleB1) (EC 2.4.1.-) (Non-LEE-encoded type III effector B1) (Q8XBX8)
Organism: Escherichia coli O157:H7
Function: Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling, apoptosis and necroptosis. Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins such as FADD: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNF-alpha receptor complex, thereby disrupting TNF signaling. Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host GAPDH protein, thereby preventing GAPDH interaction with TRAF2, leading to inhibit NF-kappa-B signaling. Catalyzes auto-GlcNAcylation, which is required for activity toward death domain-containing host target proteins (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:A0A482PDI9}. Host cytoplasm {ECO:0000250|UniProtKB:B7UI21}. Note=Secreted via the type III secretion system (T3SS). {ECO:0000250|UniProtKB:A0A482PDI9}.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase C
- Glyceraldehyde-3-phosphate dehydrogenase A
- Protein-arginine N-acetylglucosaminyltransferase NleB2
- Glyceraldehyde-3-phosphate dehydrogenase A
- Protein-arginine N-acetylglucosaminyltransferase NleB2
- Glyceraldehyde-3-phosphate dehydrogenase C
- Cysteine S-methyltransferase NleE
- T3SS secreted effector NleA/EspI
- T3SS secreted effector NleC
- T3SS secreted effector NleD
Sequence:
MLSSLNVLQSSFRGKTALSNSTLLQKVSFAGKEYPLEPIDEKTPILFQWFEARPERYEKGEVPILNTKEHPYLSNIINAAKIENERIIGVLVDGNFTYEQKKEFLSLENEYQNIKIIYRADVDFSMYDKKLSDIYLENIHKQESYPASERDNYLLGLLREELKNIPEGKDSLIESYAEKREHTWFDFFRNLAMLKAGSLFTETGKTGCHNISPCSGCIYLDADMIITDKLGVLYAPDGIAVHVDCNDEIKSLENGAIVVNRSNHPALLAGLDIMKSKVDAHPYYDGLGKGIKRHFNYSSLHDYNAFCDFIEFKHENIIPNTSMYTCSSW
Protein: Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Q54735)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation, supplies CO(2) to RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) in the carboxysome.
Subcellular location: Carboxysome {ECO:0000269|PubMed:11859847, ECO:0000269|PubMed:17993516, ECO:0000269|PubMed:9617794}. Note=This cyanobacterium makes beta-type carboxysomes. Associates with the shell portion of carboxysomes. {ECO:0000269|PubMed:17993516}.
Interaction partners:
- Carboxysome assembly protein CcmM
- Low affinity sulfate transporter
- Bicarbonate transporter BicA
- carbonic anhydrase
- Cyanate hydratase
- Slr1229 protein
- Bifunctional pantoate ligase/cytidylate kinase
- Carboxysome assembly protein CcmN
- Carboxysome shell vertex protein CcmL
- Ribulose bisphosphate carboxylase large chain
Sequence:
MQRLIEGLQKFREGYFSSHRDLFEQLSHGQHPRILFICCSDSRVDPNLITQSEVGDLFVIRNAGNIIPPYGAANGGEGAAMEYALVALEINQIIVCGHSHCGAMKGLLKLNSLQEKLPLVYDWLKHTEATRRLVLDNYSHLEGEDLIEVAVAENILTQLKNLQTYPAIHSRLHRGDLSLHGWIYRIEEGEVLAYDGVLHDFVAPQSRINALEPEDEYAPHPNSPLISYDAFKVPGKERPGREKATESPAPQLSPLPGFGHLPREQAERIYRGSR
Protein: Epoxide hydrolase (EC 3.3.2.9) (Q7KB18)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR001112}. Microsome membrane {ECO:0000256|ARBA:ARBA00004111}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004111}.
Interaction partners:
- Carboxylic ester hydrolase
- Juvenile hormone acid O-methyltransferase
- Epoxide hydrolase
- Epoxide hydrolase
- Carboxylic ester hydrolase
Sequence:
MANIWPRILVGALTILVAVGYKNYRDLSAPGKRPDLDNNAYWGPTLKEPYRENKAILPFDISVKPEVIEDLIGQLSRPLKAQAPLEGVGFQYGFNANELAKVVKYWRDTYLPKWSEREEYLKKLDHYQTEIQGLKIHFIHAKPSQVKGQKPKKVLPLLLMHGWPGTVREFYDFIPLLTTPSDKSDYVFEVIAPSLPGYGWSQGSSKTGFGVAQVAVVMRNLMLRVGFDKFLVQGGDWGSIIGSNVASLFPENVLGYHSNMCGNNSPMGQLKMVLASFFPSWFVDSEYADFYKGLGHLFSTIMEEMGYAHIQASKPDTIGNALIDNPTGLASYILEKFSTWTNTAFRSLPDGGLTKRFTYDQLLDNVMIYYVTNSITTSMRLYSESMVASQFALAVDSVPIKAKAGCTRFAHEITHFSDSVLANKFPNLVHSTHHRDGGHFPAFELPQQLYDDFVSFVQKANFS
Protein: Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (P56519)
Organism: Gallus gallus (Chicken)
Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Also deacetylates non-histone proteins. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92769}. Cytoplasm {ECO:0000250|UniProtKB:Q92769}.
Interaction partners:
- Histone-binding protein RBBP4
- Histone-binding protein RBBP7
- Histone deacetylase 1
- C-terminal binding protein 1
- Paired amphipathic helix protein Sin3a
- Retinoblastoma-associated protein
- SIN3 transcription regulator family member B
- Uncharacterized protein.
- Nuclear receptor corepressor 2.
- Recombination signal binding protein for immunoglobulin kappa J region
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSEVSMVNNFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKADVKEEDKSKDNSGEKTDTKGAKSEQLSNP
Protein: Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) (P70284)
Organism: Mus musculus (Mouse)
Function: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Homeobox protein TGIF2
- Mothers against decapentaplegic homolog 4
- Retinoic acid receptor alpha
- Ski-like protein
Sequence:
MKSKKGLVAASGSDSEDEDSMDSPLDLSSSAASGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISEASSIEAAMGIKNFMPTLEESPFHSCVVGPNPTLGRPVSPKPPSPGSILARPSVICHTTVTALKDGPFSLCQPIGVGQSTDVPQIAPSNFTDTSLVYPEDTCKSGPSPNPQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA