wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (dSpt5) (Q9V460)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development.
Subcellular location: Nucleus. Chromosome. Note=Localizes predominantly to transcriptionally active regions of polytene chromosomes.
Interaction partners:
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB3
- Transcription elongation factor SPT6
- FACT complex subunit spt16
- DNA-directed RNA polymerase II subunit RPB7
- Hyrax
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB2
- Cyclin-dependent kinase 9
- FACT complex subunit Ssrp1
Sequence:
MSDSEVSNMSDSGSEDGSISNKSQRSARSKSRSRSRSGSRGSRSVSRSRSRSQSGHSRSGSESPQRRDNRGKSDESGEEEEEPPGEDIDSEEYDEEENDDHPRKKKKKERFGGFIIDEAEVDDEVDEDDEWEEGANEIGIVGNEIDELGPTARDIEIRRRGTNLWDTQKEDEIEEYLRKKYADESIAKRHFGDGGEEMSDEITQQTLLPGIKDPNLWMVKCRIGEEKATALLLMRKYLTYLNTDDPLQIKSIIAPEGVKGYIYLEAYKQTHVKTCIDNVGNLRMGKWKQEMVPIKEMTDVLKVVKEQVGLKVKQWVRLKRGLYKDDIAQVDYVDLAQNQVHLKLLPRIDYTRMRGALRTTATESDDSKRKKKRRPAAKPFDPEAVRAIGGEVHSDGDFLLFEGNRYSRKGFLYKNFTMSAILSDGVKPTLAELERFEESPEEVNLEIMGTVKDDPTMAHSFSMGDNVEVCVGDLENLQAKIVAIDGTMITVMPKHQDLKDPLIFKASELRKYFKTGDHARVLAGRYEGETGLIIRVEPTRVVLVSDLTNHELEVLPRDLQLCSDVATGVDCLGQFQWGDMVQLDSQNVGVIVRLERENFHVLGMNGKCIECKPTALHKRKENRHTVALDADQNQIRRRDVVKVMEGPHAGRSGEIKHLYRSLAFLHCRMYTENGGIFVCKTRHLQLAGGSKTTVSNAGIVGGLGFMSPRIQSPMHPSGGRGARGGARGGRGGFRVTRDREILGKTIKISGGPYKGAVGIVKDATESTARVELHTSCQTISVDRNHIAIVGVTGKEGSVSTYGRTPARTPGYGAQTPSYTAAGSKTPLVGSQTPNWDTDTRTPYGTMTPSHDGSMTPRHGAWDPTANTTPARNNDFDYSLEEPSPSPGYNPSTPGYQMTSQFAPQTPGTLYGSDRSYSPFNPSPSPAPSPYPVGYMNTPSPSTYSPNTPGGIPQSPYNPQTPGASLDSSMGDWCTTDIEVRIHTHDDTDLVGQTGIIRTVSNGVCSVFLRQEDRSVSIVSEHLAPVLPCNGDEFKIIYGDDRESVGRVLSKDGDVFVCRINEEIKLLPINFLCKMKSID
Protein: Phosphoribulokinase, chloroplastic (PRK) (PRKase) (EC 2.7.1.19) (Phosphopentokinase) (P25697)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
- Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
- Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic
- Calvin cycle protein CP12-2, chloroplastic
- Ribulose-5-phosphate-3-epimerase, chloroplastic
- Ribulose-phosphate 3-epimerase
- Ribulose-phosphate 3-epimerase
- Sedoheptulose-1,7-bisphosphatase, chloroplastic
Sequence:
MAVSTIYSTQALNSTHFLTSSSSSKQVFLYRRQPQTNRRFNTLITCAQETIVIGLAADSGCGKSTFMRRLTSVFGGAAKPPKGGNPDSNTLISDTTTVICLDDYHSLDRYGRKEQKVTALDPRANDFDLMYEQVKALKNGIAVEKPIYNHVTGLLDPPELIQPPKILVIEGLHPMFDERVRDLLDFSIYLDISNEVKFAWKIQRDMAERGHSLESIKASIEARKPDFDAFIDPQKQYADAVIEVLPTTLIPDDNEGKVLRVRLIMKEGVKYFSPVYLFDEGSTISWIPCGRKLTCSYPGIKFNYEPDSYFDHEVSVLEMDGQFDRLDELIYVESHLSNLSTKFYGEVTQQMLKHADFPGSNNGTGLFQTIVGLKIRDLYEQLIANKATARAEAKA
Protein: Paired box 2 (G3V5S4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGPCCVWGVVFFSCLSPAGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGR
Protein: Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) (P50219)
Organism: Homo sapiens (Human)
Function: Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Insulin gene enhancer protein ISL-1
- Limb region 1 protein homolog
- Insulin gene enhancer protein ISL-2
- Growth/differentiation factor 11
- DNA-binding protein RFX6
- Oligodendrocyte transcription factor 2
- Sonic hedgehog protein
- Glycerophosphodiester phosphodiesterase domain-containing protein 5
- Pancreas transcription factor 1 subunit alpha
- LIM/homeobox protein Lhx3
Sequence:
MEKSKNFRIDALLAVDPPRAASAQSAPLALVTSLAAAASGTGGGGGGGGASGGTSGSCSPASSEPPAAPADRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYGYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFNSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDEDEDDEDHFPYSNGASVHAASSDCSSEDDSPPPRPSHQPAPQ
Protein: Purple acid phosphatase 15 (EC 3.1.3.-) (EC 3.1.3.2) (Phytase) (Q9SFU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acid phosphatase activity with p-nitrophenyl phosphate (pNPP), D-myoinositol 1-phosphate (Ins(1)P1), phytic acid and Myo-inositol hexakisphosphate. Low or no activity with Glc-6-P and ATP. Confers shoot growth stimulation, enhanced salt and osmotic stress tolerance, and ABA insensitivity. May modulate ascorbic acid (AsA) levels by controlling the input of myoinositol into this branch of AsA biosynthesis.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Multiple inositol polyphosphate phosphatase 1
- Nicotianamine synthase 1
- Probable inactive purple acid phosphatase 16
- Protein LOW PSII ACCUMULATION 1
- Inositol-tetrakisphosphate 1-kinase 1
- Protein LPA2
Sequence:
MTFLLLLLFCFLSPAISSAHSIPSTLDGPFVPVTVPLDTSLRGQAIDLPDTDPRVRRRVIGFEPEQISLSLSSDHDSIWVSWITGEFQIGKKVKPLDPTSINSVVQFGTLRHSLSHEAKGHSLVYSQLYPFDGLLNYTSGIIHHVRITGLKPSTIYYYRCGDPSRRAMSKIHHFRTMPVSSPSSYPGRIAVVGDLGLTYNTTDTISHLIHNSPDLILLIGDVSYANLYLTNGTSSDCYSCSFPETPIHETYQPRWDYWGRFMENLTSKVPLMVIEGNHEIELQAENKTFEAYSSRFAFPFNESGSSSTLYYSFNAGGIHFVMLGAYIAYDKSAEQYEWLKKDLAKVDRSVTPWLVASWHPPWYSSYTAHYREAECMKEAMEELLYSYGTDIVFNGHVHAYERSNRVYNYELDPCGPVYIVIGDGGNREKMAIEHADDPGKCPEPLTTPDPVMGGFCAWNFTPSDKFCWDRQPDYSALRESSFGHGILEMKNETWALWTWYRNQDSSSEVGDQIYIVRQPDRCPLHHRLVNHC
Protein: Cyclic nucleotide-gated channel alpha-1 (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated cation channel subunit alpha) (cGMP-gated cation channel alpha-1) (P29974)
Organism: Mus musculus (Mouse)
Function: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P29973}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel beta-1
- Cyclic nucleotide-gated channel beta-3
- Calmodulin-1
- Calmodulin-like protein 4
- Calmodulin 5
- Calmodulin-like protein 3
- Calmodulin-4
- Guanine nucleotide-binding protein G
- Cyclic nucleotide-gated channel alpha-4
- Guanylyl cyclase-activating protein 2
Sequence:
MKTNIINTWHSFVNIPNVIVPAIEKEIRRMENGACSSFSDDDNGSLSEESENEDSFFRSNSYKRRGPSQREQHLPGTMALFNVNNSSNKDQEPKEKKKKKKEKKSKADDKNENKKDPEKKKKKEKEKEKKKKEEKTKEKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDRMKLIEKYKANLQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYIFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINIANMGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIETEFSALEEPGGESELTESLQD
Protein: Indole glucosinolate O-methyltransferase 2 (EC 2.1.1.-) (Q9LPU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in indole glucosinolate biosynthesis. Catalyzes methoxylation reactions of the glucosinolate indole ring. Converts the hydroxy intermediates 4-hydroxy-indol-3-yl-methylglucosinolate (4OH-I3M) and 1-hydroxy-indol-3-yl-methylglucosinolate (1OH-I3M) to 4-methoxy-indol-3-yl-methylglucosinolate (4MO-I3M) and 1-methoxy-indol-3-yl-methylglucosinolate (1MO-I3M), respectively.
Interaction partners:
- Cytochrome P450 81F2
- Cytochrome P450 81F4
- Cytochrome P450 81F3
- Cytochrome P450 81F1
- Transcription factor MYB51
- Transcription factor MYB122
- Probable inactive 2-oxoglutarate-dependent dioxygenase AOP2
- Flavin-containing monooxygenase FMO GS-OX2
- Cytosolic sulfotransferase 16
- Flavin-containing monooxygenase FMO GS-OX5
Sequence:
MGYLFEETLSSNPKTPIVVDDDNELGLMAVRLANAAAFPMVLKASLELGVFDTLYAEASRTDSFLSPSEIASKLPTTPRNPGAPVLLDRMLRLLASYSMVKCEKVSVGKGERVYRAEPICRFFLKNNIQDIGSLASQVIVNFDSVFLNTWAQLKDVVLEGGDAFGRAHGGMKLFDYMGTDERFSKLFNQTGFTIAVVKKALEVYQGFKGVNVLVDVGGGVGNTLGVVTSKYPNIKGINFDLTCALAQAPSYPGVEHVAGDMFVDVPTGDAMILKRILHDWTDEDCVKILKNCWKSLPENGKVVVIELVTPDEAENGDINANIAFDMDMLMFTQCSGGKERSRAEFEALAAASCFTHCKFVCQAYHCWIIEFCK
Protein: Bifunctional dihydrofolate reductase-thymidylate synthase 2 (DHFR-TS 2) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] (Q05763)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Interaction partners:
- Thymidine kinase b
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase 1
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Thymidine kinase a
- Dihydrofolate synthetase
- dCMP deaminase
- Thymidylate kinase
- Folylpolyglutamate synthase
- Folylpolyglutamate synthase
Sequence:
MRCLQNSAKTLPLAFKSALLPLSQRWFCKFSPKPSSLTNIFKVSISTMANTLNGNVIMTSKPQSTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDLTLSTSDSAKKNAVVMGRKTWESIPKKYRPLSGRLNVVLSRSSGFDIANTENVVTCSSIDSALDLLAAPPFSLSIEKVFVIGGGDILREALNKPSCEAIHITEIDTSIDCDTFIPTVDTSAYQPWCSSFPICENGLRFSFTTHVRVKSSSAGEASDESDGSKVLQVDWKKFSSVLPKMIFDRHEEYLYLNLVKEIISNGNLKDDRTGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGIRIWDGNASRAYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVINKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYSLLTCILAHVCDLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPEKKDIDSFVADDFELIGYDPHKKIDMKMAV
Protein: Candida glabrata strain CBS138 chromosome F complete sequence (Q6FTV4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Elongation factor 1-alpha
- Small ribosomal subunit protein eS1
- Translationally-controlled tumor protein homolog
- Candida glabrata strain CBS138 chromosome D complete sequence
- 60S acidic ribosomal protein P0
- Candida glabrata strain CBS138 chromosome J complete sequence
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
Sequence:
MAFTDFSKIDTVKELNTVLGEKSYVEGTSATQADVEAYKAFRTAYPNFSRWFNHIAAKADEFDSFPAASGASAAAEEEDDDDVDLFGSDDEVDEEAEKLKAQRLEEYNKRKAAKGPKPAAKSIVTLDVKPWDDETDLEEMLANTKAVQMDGLNWGAHQFIPIGFGIKKLQINCVVEDAKVSLDDLQQAIEDDEDHVQSTDIAAMQKL
Protein: Transmembrane protein 126A (Q9H061)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:19327736, ECO:0000269|PubMed:23500070, ECO:0000269|PubMed:38199007}; Multi-pass membrane protein {ECO:0000269|PubMed:19327736, ECO:0000269|PubMed:23500070}.
Interaction partners:
- L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
- ATP synthase F
- Tumor necrosis factor ligand superfamily member 9
- NAD
Sequence:
MENHKSNNKENITIVDISRKINQLPEAERNLLENGSVYVGLNAALCGLIANSLFRRILNVTKARIAAGLPMAGIPFLTTDLTYRCFVSFPLNTGDLDCETCTITRSGLTGLVIGGLYPVFLAIPVNGGLAARYQSALLPHKGNILSYWIRTSKPVFRKMLFPILLQTMFSAYLGSEQYKLLIKALQLSEPGKEIH
Protein: EG:BACR42I17.11 protein (RE55560p) (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform D) (Q9V3X8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein, isoform A
- LD23875p
- LD41913p
- Uncharacterized protein, isoform B
Sequence:
MTEVQYKEAEILALLPHTYEDEELSLNTEELQFEELNERSQHQQGGSPSFVCRRCPALFLTREELAAHRPTHRYQGGQQTPASEHACDACGRVFQKHNALVDHMNAHNDVRNYPCPECPARFVQRSNRECHLKNVHRKVYLHSCPEPGCKKRFQQRRECDQHVKTVHQNERNLVCDTCSARFSHPVNYRKHLASHGSAKSYGCPICGKLFGRPENRDVHLFVHSICKAYICSVCGADYMRRNQLIRHGLASGHHNDPIVRQKPQFSPALAAKNRSQRSAIDESQDEELQWLKGVDALDSAGYLENSQFSNTGKMTAIFAEDENESELFN
Protein: H-2 class I histocompatibility antigen, K-B alpha chain (H-2K(B)) (P01901)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Beta-2-microglobulin
- Killer cell lectin-like receptor 3
- T-cell surface glycoprotein CD8 alpha chain
- T-cell surface glycoprotein YE1/48
- T-cell surface glycoprotein CD8 beta chain
- H-2 class I histocompatibility antigen, D-B alpha chain
- Tapasin
- Killer cell lectin-like receptor subfamily A member 9
- Histocompatibility 2, O region beta locus
- Antigen peptide transporter 1
Sequence:
MVPCTLLLLLAAALAPTQTRAGPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNMATVAVLVVLGAAIVTGAVVAFVMKMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Protein: Protein SCO2, mitochondrial (P38072)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}.
Interaction partners:
- Cytochrome c oxidase assembly factor 6
- Cytochrome c oxidase copper chaperone
- Heme A synthase COX15
- Cytochrome c oxidase assembly protein COX11
- Protoheme IX farnesyltransferase, mitochondrial
- Cytochrome c oxidase subunit 2
- Cytochrome oxidase assembly protein SHY1
- Cytochrome c oxidase assembly protein COX18, mitochondrial
- Protein PET100
- Protein PET117
Sequence:
MLNSSRKYACRSLFRQANVSIKGLFYNGGAYRRGFSTGCCLRSDNKESPSARQPLDRLQLGDEINEPEPIRTRFFQFSRWKATIALLLLSGGTYAYLSRKRRLLETEKEADANRAYGSVALGGPFNLTDFNGKPFTEENLKGKFSILYFGFSHCPDICPEELDRLTYWISELDDKDHIKIQPLFISCDPARDTPDVLKEYLSDFHPAIIGLTGTYDQVKSVCKKYKVYFSTPRDVKPNQDYLVDHSIFFYLIDPEGQFIDALGRNYDEQSGLEKIREQIQAYVPKEERERRSKKWYSFIFN
Protein: Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) (Q08920)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the CBC complex, which binds co-transcriptionally to the cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.
Subcellular location: Nucleus. Cytoplasm, perinuclear region. Note=Predominantly nuclear, is able to exit the nucleus in an RNA-dependent manner.
Interaction partners:
- Pre-mRNA-processing factor 39
- U2 small nuclear ribonucleoprotein A'
- Protein LUC7
- U1 small nuclear ribonucleoprotein A
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein component PRP42
- Small nuclear ribonucleoprotein Sm D2
- Protein NAM8
Sequence:
MSLEEFDEVKYDHSTKRLDTPSRYLLRKARRNPNGLQELRESMKSSTIYVGNLSFYTSEEQIYELFSKCGTIKRIIMGLDRFKFTPCGFCFIIYSCPDEALNALKYLSDTKLDEKTITIDLDPGFEDGRQFGRGKSGGQVSDELRFDFDASRGGFAIPFAERVGVPHSRFDNSSSQSNTNNYIPPPDAMGTFRPGFDEEREDDNYVPQ
Protein: Tubulin beta-3 chain (Neuron-specific class III beta-tubulin) (Q4QRB4)
Organism: Rattus norvegicus (Rat)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9ERD7}.
Interaction partners:
- Tubulin alpha-1B chain
- Microtubule-associated protein tau
- Gap junction alpha-1 protein
- Tubulin alpha-4A chain
- Tubulin alpha-8 chain
- Tubulin alpha-1C chain
- Tubulin alpha-1A chain
- Tubulin alpha chain
- Tubulin alpha-3 chain
- Neuronal migration protein doublecortin
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDDEESEAQGPK
Protein: Protein RecA (Recombinase A) (E7CG23)
Organism: Deinococcus murrayi
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00268}.
Interaction partners:
Sequence:
MSKDNPKDFGTPSDSKERLKAIETAMTQIEKAFGKGSIMRLGAESKLDVQAVSTGSLSLDLALGVGGIPRGRITEIYGPESGGKTTLALSVIAQAQKAGGTCAFIDAEHALDPVYARSLGVNTDELLVSQPDNGEQRLEIMELLVRSGAIDVVVVDSVAALTPRAEIEGEMGDSLPGLQARLMSQALRKLTAILSKTGTAAIFINQVREKIGVMYGNPETTTGGRALKFYASVRLDVRKIGQPVKMGNDAVGNTVKVKTVKNKVAPPFKEVELTLMYGKGFDQLSDLVTLASDMDIIKKAGSFYSYGEDRLGQGKEKAIAYIAERPELEAEIRERVLSAIKEGRAGDVPGVASVPAVAE
Protein: At5g40430 (Myb domain protein 22) (Transcription factor) (Q9SPH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH9
Sequence:
MGEPQLFDVPVLEGIKNTTNEIMNQLEDDKMKKTYENKKEASTSKYLKKSDITKKRWTESEDIKLKEMVALEPKKWTKVAKHFEGRTPKQCRERWHNHARPNVKKTTWSEEEDQILIEVHKVIGAKWIQISEQLPGRSYNNVKNHWNTTKRRVQNKSGRTVNRVGNNILENYIRSITINNDDESDGEPTNIENYHDDSEDMLYGEMNLSPEAITQTTKPLTDASTISPYIPMPKENYTLEVCESLEDYLELLRWWD
Protein: Putrescine hydroxycinnamoyltransferase (EC 2.3.1.-) (Q7XXN4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydroxycinnamoyl transferase that catalyzes the transfer of an acyl from p-coumaryol-CoA to putrescine, to produce coumaroyl putrescine. Can use feruloyl-CoA, caffeoyl-CoA and sinapoyl-CoA as acyl donors. Seems to be able to transfer the acyl group from feruloyl-CoA to the acyl acceptors agmatine and spermidine.
Interaction partners:
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- 4-coumarate--CoA ligase
Sequence:
MEVKVLSSRLVRPSYPASAAAPEEEFVPSSMFDKVTYDMQMAIIYAFRPPGPSVADIEKGLAAVLGVYRLFAGQVVRGGGGELRGVVLNDHGARLVEACVDGSLADIAPAKPSPVVLRLHPSLEGEIEEVVQVQLTRFACGSLAVGFTANHAVADGHATSDFLVAWGRAARGLAVAATAAAPPHHHPGMFRPRDPPLVEFEHRGVEYYRPPPPAAGVDGDVGGDHKQQHGHGGEEASHGIVIHKAHFTKDFIARLRAAASEGRGRPFSRFETILAHVWRTMTRARGLGNPLQSSTIRISVDGRQRLSAPAGYFGNLVLWAFPRATVGDLLGRPLKHAAQVIHDAVARADAAYFRSFVDFASSGAVEGEGLAPTAVLKDVLCPDLEVDSWLTFPFYELDFGGGCPTYFMPSYFPTEGMLFLVPSYLGDGSVDAFVPVFDHNLEAFKQSCYSIE
Protein: Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (O35716)
Organism: Mus musculus (Mouse)
Function: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (By similarity). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O15524}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O15524}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. {ECO:0000250|UniProtKB:O15524}.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Non-receptor tyrosine-protein kinase TYK2
- Elongin-B
- Tyrosine-protein kinase JAK1
- Elongin-C
- Cullin-2
- Interferon gamma receptor 1
- Cullin-5
- Interferon alpha/beta receptor 1
- Suppressor of cytokine signaling 3
Sequence:
MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI