Protein: General negative regulator of transcription subunit 1 (P87112)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- General negative regulator of transcription subunit 2
- Poly
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- Cell differentiation protein rcd1
- General negative regulator of transcription subunit 3
- Putative general negative regulator of transcription C16C9.04c
- Putative ATP-dependent RNA helicase ste13
- ABC transporter domain-containing protein C20G4.01
- Mitochondrial division protein 1
- Deadenylation-dependent mRNA-decapping factor pdc2
Sequence:
MKSQEQQTPETREKSSSTSESGHPISLDSKTPPPNDSKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGTGKSSDGLATYKLLLDELKSLTKSWVMAKRFSDAISGSDSEVFEDFDIEAFLDHFQFSPLERTNLLIGLTTSVKPTLAKKASALLKNTFQSLLNQLSDPTQQQSIDKNDLDLLREGLFTTDYDRIPLIKVPKFDAIIEKKLANSRPLTALFGPMKASKATLKSMKEAILKKYPPGTATETDVAYLINSLVAIHDYGAWDTVLMGKAIVSSFENLNWEAMLSMFDNPKFMITGTPSLVLFFTIFTNAYKLRQTNFTLDFLWVLWRNPLPQLSIISHIILSPTSMFDIREFNVNPVVSVDSLKDYSEELVNYAKIYEKSNLNCIELVQILLRLLSEVVTYETSLFLNFLDEKVSAELLLLGTLQLPLAWNPVQESLAFQWCSDFFSNFKEHKFVFVRIERTNPQFLFAFLRSLWLKDSSSVNQVVEFIIENDFTSHIGNIQPNRFALEIAALAAARKALSFQDWLDKKMLEFEDADGLNVFLVEVLDFLMSRAALQKNESEQKEESVVLSIDTVNVLLTTLMDNVSISEEVSEHIKDVQILCLQVYPRLFSLGHDRDSIVIATNTTNSFSPDVESEVESYFQALYERRISIGKIVLTLQNFKKSENPRDLDLFACLQHSLFDEYRFFPDYPLEALALTAVLFGSLIQFELLSFVPLGVALRYVYQALLMPTDSKMFRFGMQALVQFQEKLPKYINYCNLILGIPSLQLVRPDIYDSIREMIASNENTEVEKDKLDSFSALANPASPKAPEYTFVSIHVPPLNVPNAEGEIEESVCDNILFAINNLSQLNFNEKLKDVKDNLTPAYLPWFSHYIVTQRVSREANFLSLYGKFLEELKSSDLYKIVFRDTLQAILDIMNNNAETLSPSEKTNLKNLGSWLGSITLLRNKPITTLQVSFKDLLLEGIDSGRIDRVLPFVCKVLEKASSSVIFKPPNPWLMGILKLLVELYQFADFRLNLKFEIELLLNNLNVKMDNIEPSEMYRNHLVQKADLEKELPEDVLNAEFPDGTDVITQYIVAASSQITVTDAVAQVFGKPKPAIKNITQLIIQQSVLEIISAVVRRSVGIAAITTKSLLQKDFAAESNPSRLLLAARQMAKTLAGNLAMVTCREPLQMLMINNFRTIALQDVENVHAAVAQAIDELVSQNLFVASSVIESVASETAIAEIDAEIEHMIVERVRHRKTTPNLPFVDPAGAANLHLNLPSVLKLSSELTPQQFQLYENFDRLSLSTIMSNNSFTSLNGLRTDSADSTDALNSNLNNTVENEANQTALNYARNLLIIIGQLFQLAAQMPYTSMQEVPADHELHELVNQFLTGVASINHPIADHVFLLCAQECCRILLTDSKSPFILEVFSAILEYICQASTKTAINVSLYWNFSNDLEKLNLPIILSLIRFGILTSGEVDYHVARGVRSEQGSGPVTDFAIELLRTAVGGENPMALPGNFVNSITSLYEISESFSGETKQAYEQLVETMNKSVSPASEILSDLDNKQQLNDQIIIVFVSWVHLLRNSATNDETKAAFVYQLHKQGILSEPELCIQFFRCNLEAVLVAFLEAASVNAPDYFNVDAYASLLVNVVKYTEGSTEGTVSSKSVLFRKIIALIIGVFAELHNSMAEFVHQKTFFRLFSSILSELDDAKDVLESCFVDIYSVILECFLAIQPRSFPAFTFAWLSLISHSYLLPKVLLVNNDKINDLFSEILMSFLKFLDLKDDIDKAQFKLLYNGFLRIILVLLHDFPGFLATHCYQLIPYIPLECVQLRNMVLSAFPSDLHLPDPFAQGLKVGRLPEVTRAPLISNSVSASLEKFASALDLEACFSSSKPAEVAKLLLEVYSSQDTPTKLNEWANYFMLCLIRHATRDSPAKQAPQFQSKSPECVIISTMNRSCDSKCRYFLLTAIANQLRYPSSHTYYASCCFLYLFKSSSNNPQELLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLFDSLHEHVMAPSSANNVSTEEATELMGQV