wanglab/gogpt-training-data huggingface dataset:
Protein: Reticulocyte-binding protein 2 (PvRBP-2) (Q00799)
Organism: Plasmodium vivax (strain Belem)
Function: Involved in reticulocyte adhesion. Specifically binds to human reticulocyte cells.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEKNVLWVIFYNFLVILLASCNDSNRSKSNSLKSESKSLPTYANLMRNGQDKYNNAKTEDNIGNQINNDNNHNGYNDNRINSEYPKTSHLQHSPSLVHLNDHKFTTKPSRHSYVQRNSIYKRNTNNNMENTNNELHVVPNFFIQEKKAAPQKPSVQNTPTATQIVYNNLDYLNAFDDTNNIISAFKPHHPIIYYFKQLEHFANSYYDLRNKIKDYFALPMKQASDVVEKNVKDCLQNINESRILMTQLENPQNYNDISDKYDEKVKEYKKKIEDMQICLKDSYIKNFKAIMSANLKMNLALNGIYIHWWYLTCSTKTYDDIVKEYAIEINDFDEKKSISFMDNMKKIHKSAIDTLKKMKAELNTSLDSKRTEFIIGEIGHMIEKFNLHLTKIRYASAFIKSIPLQKVESDIYRVELKTLFYVAAKHYADFKFSLEHLKMFENLSKSKEKMLYSTFEKLEGDLLNKINTLMGSEQSTSDLTSIIADSEKIIKSAESLINSSSEEIAKYALDSNEKINEIKKNYDQNILKVREFINKSNGLITSVKGTSQLSESDKQQIETKIEEIKKKKKDILERGKEFINIMNEIKKKKKSNSSNSSTNSKEFTDKLKELETEFEGLNKTVKGYLQEIEDIKVKENEDRSLKNQIEQHLKYTSDNRDNVKTLISKNDEIQKYIEKIEKLINDAPSGKDKFTTEKTNLQNKVKKIIDEFHKEDLQLLLNSLSKFYEEHQKLYNEASTIEKIKDLHQKTKEEYEKLEKMKFSNFGQILDKLNTELDNLKTLEKNIVEEQTNYINKVMSDSLTNLTAEVDNLRSALDGYRADETELKTYKNRINERKEKFLSTLKEQEDDIPDGKNIYEEYNNHKNVMVNKEHKISSDINQCNENIIKAEKNLETFNTLVQTLDAHTGKKDQKVHDLLQKFKTNLEKLNLNELESGFKSLNGSASTTNKQIENIRKNIDTIKSLNFAKNSSESSKLSLENIIKNKADLIKKLDQHTQEIEKHTFIENEEMSPLLSVIKKEKNRVESDMSEELIKQLNTKINAILEYYNKSKDRFNGDDETNLEELDDFKKQCQDAQQEIKKLTTNYNVLDNGINVIIKEQHEKVIILSENHITEKDKKINEKIQQNVNSLNEMKTKLGLLKINEDIKNSRDTTIKSKIQEFEKKVQTIFGSIDVANKKIDAIKKEHDVNKDEFDKEKVKDTSFDEKKKSIEKAYEKMGNTLKELEKMDDEKNIEKEVEEAQIQYKRIFIDHDVNLMNDEVEKSKIVMEKIELYKKEIDEIKQKTNEYKQGDTSNFYYTEQYNSATQSKAKIEQFINIATTKKGTSDTSQDINELESIKEEVHKNLQLVKQESNSMEEMRKQILSMKDLLILNNSETIAKEISNNTQNALGFRENAKTKLNKTDELLQRVAAMIEEAKAHKNNIDIALEDAQIDTEVSKIEQINREIMNKKDEIKSYLSEIKEYKDKCTTEISNSKRGKDKIEFLEKFKPNEESNSNKVNINEINENIRNSEQYLKDIEDAEKQASTKVELFHKHETTISNIFKESEILGVETKSQKKINKAEDIMKEIERHNSEIQTQVKGFQENLNKLNEPHNYDNAEDELNNDKSTNAKVLIETNLESVKHNLSEITNIKQGGEKIYSKAKDIMQKIKATSENTAEKTLEKVKDDQSNYVNYLNQITTERNLIVTEKNRLNGIDSTITNIEGALKESKGNYEIGFLEKLEEIGKNRKLKVDITKKSINSTVGNFSSLFNNFDLNQYDFNKNINDYENKMGEIYNEFEGSLNKISENLRNASENTSDYNSAKTLRLEAQKEKVNLLNKEEEANKYLRDVKKVESFRFIFNMKESLDKINEMIKKEQLTVNEGHGNVKQLVENIKELVDENNLSDILKQATGKNEEIQKITHSTLKNKAKTILGHVDTSAKYVGIKITPELALTELLGDAKLKTAQELKFESKNNVVLETENMSKNTNELDVHKNIQDAYKVALEILAHSDEIDTKQKDSSKLIEMGNQIYLKVVLINQYKNKISSIKSKEEAVSVKIGNVSKKHSELSKITCSDKSYDNIIALEKQTELQNLRNSFTQEKTNTNSDSKLEKIKTDFESLKNALKTLEGEVNALKASSDNHEHVQSKSEPVNPALSEIEKEETDIDSLNTALDELLKKGRTCEVSRYKLIKDTVTKEISDDTELINTIEKNVKAYLAYIKKNYEDTVQDVLTLNEHFNTKQVSNHEPTNFDKSNKSSEELTKAVTDSKTIISKLKGVIIEVNENTEMNTIESSAKEIEALYNELKNKKTSLNEIYQTSNEVKLQEMKSNADKYIDVSKIFNTVLDTQKSNIVTNQHSINNVKDKLKGKLQELIDADSSFTLESIKKFNEIYSHIKTNIGELEQLQQTNKSEHDNVAKHKEKIVHLINRVESLKGDVKNHDDDQYMKKLNASLLNDNIKNTNSINISDEELKKLLKKVEENDQLCKNNNTQNFISDIMKRVEDLNRRFTENLPEKEKLHQIENNYNEISSIFSEINLQDVDEFVAKIHKQIDAEKASVNNVREAEKIRTAIQNVTSYDTEIISRLSEMNNVLERITTRKTKMDQLLKSLSPDNTSLNLNARTHVRKSEDIIKQLNSHIGEITELNTYAHEVMTYLENELNKLLKQLEIERAKLETKTSPSGMKAKEEKVPPKETENRAQDNLASVPQKTLEDNTQQMPENSVQDNLASVPQKTLEDNTHQMPENRVQEDSISAPQEQVEYSTLAVPENDETTEEESEHDDAHDDTHDDTHDDTHDDTHDDTHDDTHDDTHDESQTGRDSTAKEAIGKTRLAGAVIIAMSVLSGFIIIVFKDKDEEEKDHNEHGYNEAFGEHDEYNMHDKEEVIEVCFNEED
Protein: Esculetin O-methyltransferase (EC 2.1.1.-) (Bergaptol O-methyltransferase) (EC 2.1.1.69) (Isoscopoletin O-methyltransferase) (EC 2.1.1.-) (Scopoletin O-methyltransferase) (EC 2.1.1.-) (Xanthotoxol O-methyltransferase) (EC 2.1.1.70) (A0A4P8DY91)
Organism: Kitagawia praeruptora (Peucedanum praeruptorum)
Function: O-methyltransferase involved in the biosynthesis of methoxylated coumarins natural products such as isoscopoletin, scopoletin, xanthotoxin and bergapten, photosensitizers used for medical purpose such as treating psoriasis and vitiligo or facilitating resistance to microbial infection and other stresses. Catalyzes the methylation of esculetin, bergaptol and xanthotoxol, but seems inactive on scopoletin and isoscopoletin.
Interaction partners:
Sequence:
MTTTELIPPTIQVDEEEEEACMFAMQLASASVLPMVLKSAIELDLLESIAKAGPGAYVSPSELAAKLPSSQPDTPVMLDRILRLLASYSVLKCKVQDLPQGGVERLYALAPVCKFLTKNSDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDPRFNKVFNLGMSNHSTITMKKILQTYNGFAGLKTVVDVGGGTGATLNMIISKYPNIKGINFDLPHVVEDAPSYPGVEHVGGDMFVSVPEGDAIFMKWICHDWSDAHCLSFLKNCYKALPQNGKVILAECILPEAPDSKLTTKNVIHIDVIMLAHNPGGKERTEKEFEALGKMAGFKSFNKVCCAHNTWIMEFLK
Protein: Protein Cep89 homolog (Q7JVA5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for mitochondrial complex IV activity. May be involved in non-associative learning.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}.
Interaction partners:
- Centriolar coiled coil protein 110kDa, isoform B
- Twitchy
- Centrosomal protein Cep290
Sequence:
MSTRNVMITDLDQPDPNQQQHHQNPKKNRKVLQTLSGNFNRRSRSVEVEVKRQDNLGVVHKDRKKDRSFNSLLQAKDQQLEQLVQRLATLHRYNDQFAKENDQLRKDSGQLERRLTEAEQQVANCSRCQQLGQRLDTVLAQNRTLAGDVDMLKTLVFRLNVQIESYQDQRRLGEGAPTCGGSTKVSSSSAPYPPLPTHTLGPLLQAYDESLRDKDALLAQYNTEFEHFTGELKRALEENTKLLQSQEQLRRDLGGWREERVCLQAQLGVCRSKAEAQTRKTDLAKEKLVEVMHCYEQRMQTLILDMDHLQAAYARTKSELAALKSASSAAPAAVAPPVPAESEALHQCKALLEQLRQEHARERTCLQEQLQATTARAASLVRSTEKAKHSRDRLKARLRMALQWAQKLEAGQAEVRDTYEAVRRLEVLVQHKESQLRGLHARNAEEMDKLRHKLQQKEETICALLRGKMERRPAVD
Protein: Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (F8VZN8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, stress fiber {ECO:0000256|ARBA:ARBA00004529}.
Interaction partners:
Sequence:
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE
Protein: Homeobox protein orthopedia B (Q6DGH9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138, ECO:0000269|PubMed:17180684}.
Interaction partners:
- Single-minded homolog 1-A
- SIM bHLH transcription factor 1b
- Oxytocin
- Corticotropin-releasing hormone b.
- Corticotropin-releasing hormone a.
- Aryl hydrocarbon receptor nuclear translocator 2
- Arginine vasopressin
- Tyrosine 3-monooxygenase
- Helix-loop-helix protein 2
Sequence:
MLSHADLLDTRLGMKDAAAELLVHREALKCRLGGTDSGHPGDLTSATETVEGTTLLPGEEISNGGSNPNGMQQVNAKDQEKQQQQNSNQTGGQQNQQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTHGLPQFPSAAAAAMGDSLCSFHANDTRWAAAGMPGVSQLQIPPSLGRQQAMAQSLSQCSLGAGPPPNNMGLSGSLSSNGSGLQSHLYQPTFPGMVPASLSGPTNVTGSPQLCSSPDSDMWRGTSIASLRRKALEHTVSMSFT
Protein: protein acetyllysine N-acetyltransferase (EC 2.3.1.286) (A0A8I6APP5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MCKARRIFDPPEELECKVWELARLMWQSSTVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDITFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDALPDRDLTLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLCIHGYVDEVMCKLMKHLGLEIPTWDGPRVLEKALPPLPRPVAPKAEPPVHLNGSYKPKPDSPVPHRPPKRVKTEAAAS
Protein: Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1) (Q04742)
Organism: Mus musculus (Mouse)
Function: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Subcellular location: Nucleus {ECO:0000269|PubMed:29263200}.
Interaction partners:
- T-box brain protein 1
- Forkhead box protein G1
- Neurogenic differentiation factor 6
- DNA-binding protein SATB2
Sequence:
MFQPAAKRGFTIESLVAKDGGTGGSPGSGGAGSHPLAVAASEEPLRPTALNYPHPSAAETAFVSGFPAAAAAGAGRSLYGGPELVFPEAMNHPALTVHPAHQLGSSSLQPPHSFFSAQHRDPLHFYPWVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLAGSLSLSETQVKVWFQNRRTKYKRQKLEEEGPESEQKKKGSHHINRWRIATKQANGEDIDVTSND
Protein: Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) (Q5VTQ0)
Organism: Homo sapiens (Human)
Function: Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).
Interaction partners:
Sequence:
MDAVLACRLRGRGNRVAALRPRPRPGGSAGPSPFALLCAGLSPEPRAGVGSEFPAWFLGGSSQRRNMALLGSRAELEADEDVFEDALETISISSHSDMATSSLHFASCDTQQAPRQRGASTVSSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPWAKESMYHALGYSTIVVLQAVLTFEQQDIQNGISAMKDALQTCQKYRKKYTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHEIQKNKLQQEFFYEFEGGVKLGSGAFNLMLSLLPARIIRLLEFIGFSGNRELGLLQLREGASGRSMRSALCCLTILAFHTYISLILGTGEVNVAEAERLLAPFLQQFPNGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD
Protein: Elongation factor Tu 1 (EF-Tu 1) (EC 3.6.5.3) (Bacteriophage Q beta RNA-directed RNA polymerase subunit III) (P-43) (P0CE47)
Organism: Escherichia coli (strain K12)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Between 50-80% of the protein is associated with the cell inner membrane. Localization to the membrane has been suggested to follow nutrient stress.
Interaction partners:
- Large ribosomal subunit protein bL36A
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL25
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein bL34
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL3
Sequence:
MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG
Protein: Serine/threonine-protein kinase STN8, chloroplastic (EC 2.7.11.1) (Protein STATE TRANSITION 8) (Q9LZV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Light-dependent serine/threonine protein kinase that specifically phosphorylates N-terminal threonine residues in psbA/D1, psbD/D2, psbC/CP43 and psbH, which are components of the core antenna complex of photosystem II. Phosphorylation of PSII core components facilitates the exchange of chlorophyll proteins between the grana and the stroma lamellae. Also involved in the phosphorylation of the calcium-sensing receptor (CaS).
Subcellular location: Plastid, chloroplast thylakoid {ECO:0000305|PubMed:16237446}.
Interaction partners:
- Dual specificity phosphatase Cdc25
- Origin of replication complex subunit 2
- Cyclin-dependent kinases regulatory subunit 1
- Cyclin-dependent kinases regulatory subunit 2
- Retinoblastoma-related protein 1
- Cell division control protein 6 homolog B
- Cell division control protein 6 homolog
- Wee1-like protein kinase
- F10B6.17
- Serine/threonine-protein kinase ATR
Sequence:
MASLLSPATPTATSAAFHSCSTAGFSTPTHISSQNSSLSLLSRRGCMMRCSFSPQDIPVDSLSHLPPFLDFQNSLATFSDTQKWGFFVSAGIVWFYLTARPGVLIGAIDAYLLAPLQLGLDTLIGRRLKRSDFLVTEKLGEGSFGVVYAGVLLPKNSTLVDDVRVSKARAKAMDFTGEFKQRVILKKVKVGVRGAEEFGEYEEWFNYRLSRAAPDTCAEFLGSFVADKTNTMFTKGGKWLVWRFEGDRDLADYMKDRSFPSNLESIMFGRVLQGVESVKRRALIIKQIMRQIITSLRKIHGTGIVHRDVKPANLVVTKKGQIKLIDFGAAADLRIGKNYIPERTLLDPDYCPPELYVLPEETPSPPPEPIAALLSPILWQLNSPDLFDMYSAGIVLLQMAVPTLRSTAGLKNFNLEIKSVEYDLNRWRERTRTRPDLSILDLDSGRGWDLVTKLISERGSLRRGRLSAAAALRHPYFLLGGDQAAAVLSKLSFSK
Protein: Rhomboid-like protein (Q582A1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAGEGAVSGAIAAVLCGTALLSTFSTVVPRVLGFIPAHTFSARSYPWNLITYVVVETNIVLAVCSAVYMLTFGVAVESIIGTRALVRLIAASTVSASLTLLILSALLYNVGFTWFLQCYCGVWPAASGILVPWVGVSPRSPAFPSQLPRQVQRQHVPTALLAITLVIDWLFRGQHRITENDVGGTKVFLGSVFTPALLGLLTTWYLQSALNTPSVVPLSVLLEPLLKLCGMVSKAPRQQGSGDGSRAGSGSGGITDTVAVPVLQGAAAGALLPGSTEEEAQRRRNIALAALSSRVQQTTADTAATQHDAAVV
Protein: Zgc:175135 protein (B0BLX6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSFSSSIAGPKAFSDSSANGAVSGDAIHIGRLSIGGQSVEPDNKKDKSRPASAEQTIEDERFRLARAKLQRLGPSLQCGNDSMTLNIKGHRTPHFLVERGEGSPVSLSEMPASCGFSLKRARRDVSLVAPYTGCNVRQQGGSYVLPLIIMGAPVQMSCPVSPRLPVVSCTSSGMIVSFGVREDDVLVKVSGSWMPLSLTSSMCSFTLDNFGGSMVLTAPFTGSCWDSQDTDWNLTLLLGDREVVLSCPKATDTPTVPPTPFPQGYPYFPFGYPWWYPWNQAPPAAPPTTPAPVKAPVYNPFPMYYPYYYGGFPHRRHHHRHWYPESQESWFPMLPPYEFAQFQPPPTPAAPQVQQYPVFPMPFNPVNTGFKNPFWPPVPQSVSNPQSLNSPWNIWARKQKR
Protein: p44-16b outer membrane protein (Q2GIK9)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MRSRSKLFLGSVMMSMAIVMAGNDVRAHDDVSALETGGAGYFYVGLDYSPAFSKIRDFSIRESNGETKAVYPYLKDGKSVKLESHKFDWNTPDPRIGFKDNMLVAMEGSVGYGIGGARVELEIGYERFKTKGIRDSGSKEDEADTVYLLAKELAYDVVTGQTDKLTAALAKTSGKDIAQFANAVKITNSTIDGKVCSGKHAALVTGKGKTYHEKPGTTEDNSAQCSGLGDGSAGADQKFLSKFVSAVGLSENKNWPTGQAGKSTSGPEVGAPNSNANAVAKDLVALNRDEKTIVAGLLTKTIEGGEVVEIRSVSSTSVMVNACYDLLSEGLGVVPYACVGLGGNFVGVVDGHITPKLAYRLKAGLSYQLSPEISAFAGGFYHRVVGDGVYDDLPAQRLVDDTSPAGRTKDTAIANFSMAYVGGEFGVR
Protein: Junctophilin-4 (JP-4) (Junctophilin-like 1 protein) (Q80WT0)
Organism: Mus musculus (Mouse)
Function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16809425}; Single-pass type IV membrane protein {ECO:0000269|PubMed:16809425}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Triadin
- Ryanodine receptor 1
- Aspartyl/asparaginyl beta-hydroxylase
- Ryanodine receptor 3
- Synaptophysin-like protein 2
- Junctophilin-3
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Stromal interaction molecule 1
Sequence:
MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPACRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGVQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEVEEPAPTERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT
Protein: Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2 homolog) (Q8JHF0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Cell membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250|UniProtKB:Q9NZ42}.
Interaction partners:
- Gamma-secretase subunit Aph-1b
- Presenilin-2
- Presenilin-1
- Ncstrn_small domain-containing protein.
- Zgc:114200.
- Neurogenic locus notch homolog protein 1
- Notch receptor 1b.
- Amyloid beta
- Amyloid beta
- Beta-secretase 1
Sequence:
MNLERIPNEEKLSLCRRYYLGGFAFLPFLWLVNILWFFKEAFLKPAYTEQPQIKSYVKKSALGLLLWVAVLTTWITVFQHFRAQWGEVGDYLSFTIPLGTA
Protein: E-beta-caryophyllene synthase (TpCarS) (EC 4.2.3.57) (F8UL81)
Organism: Tanacetum parthenium (Feverfew) (Matricaria parthenium)
Function: Sesquiterpene synthase involved in the biosynthesis of beta-caryophyllene, a sesquiterpene with anti-inflammatory and anti-carcinogenic activities.
Interaction partners:
Sequence:
MSAKEEKVIRPIVHFPPSVWADQFLIFDDEQAEQANVEQVVNELREDVRKDIVSSLDVQAEHTNLLKLIDAIQRLGIAYYFEGEIEQALQHIYDTYGDDWKGRSPSLWFRIFRQQGFYVSCDIFKNYKEEDGSFKESLTNDVEGLLELYEATYLGVQGEGILDDALVFTRTCLDKLAKDLVHSNPTLSTHIQEALQQPLHKRLTRLEALRYIPTYEQLSSHNESLLKLAKLGFNLLQSLHRKELSEVSRWWKGLDIPNNLPYARDRMVECYFWALGVYFEPKYSRARIFLAKVISLATVLDDTYDAYGIYEELKIFTEAIQRWSITCIDTLPEYMKLLYKGVLNIYKEMEEIMGKEGKAHHLSYAKESMKEFIRSYMMEAKWANEGYVPTAEEHMSVAFVSSGYSMLATTCFVGMGDIVTDEAFEWALTKPPIVKASCAIARLMDDIHSQKEEKERIHVASSVESYMKQYDVTEEHVHKVFHKKIEDAWKDITRESPVCKDIPMPLMTRVINLARVMDVLYKHKDGFTNVGQELKDHIKSLLVHPIPI
Protein: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (Malate dehydrogenase [quinone] cytochrome b560 subunit) (QPs-1) (QPs1) (Q9CZB0)
Organism: Mus musculus (Mouse)
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99643}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q99643}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Fumarate hydratase, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
MAAFLLRHVSRHCLRAHLNAQLCIRNAAPLGTTAKEEMERFWKKNTSSNRPLSPHLTIYKWSLPMALSVCHRGSGIALSGGVSLFGLSALLLPGNFESYLMFVKSLCLGPTLIYSAKFVLVFPLMYHSLNGIRHLLWDLGKGLAIPQVWLSGVAVVVLAVLSSGGLAAL
Protein: Seminal vesicle secretory protein 2 (Q8C1W4)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKSSVFVLSLLLILERQSAVVGQYGATKGNFQSSSSEGFMLGQKGRLSFGIKGGSDEAAEESLFMQSQRRVYGQGGGDMTQTRVSQEHTSVKGAALCRNGQVSQLKSQESQIKSYGQVKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGQLKSGGPAFGQVKSQESQIKSYGPLKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGSQVKSYGQTKSYGEEGQLNSFSQLKSQGAQLKSYGQQKSQQQSSFSQVKSQSSQLKSYGQQKSLKGFSQQTQHKGFAMDEGMSQVRKQFSDDDLSVQQKSTQQMKTEEDLSQFGQQRQYGQERSQSYKGYLEQYRKKVQEQQRKNFNPGNYFTKGGADLYQAQLKG
Protein: Olfactory receptor (Q8VFV6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MIGERNITKITQFILLGFSDFPRITVPLFVMFLMIYTLAVTWNFSLIALIRLDSHLHTPMYFFLSNLSIIDICYITSTAPKMLSNFFQEKQTISFVGCIVQYFILSTMGLTESCLMTAMAYDRYAAICNPLLYSSVMSPTLCAQMVMGSYTAGLTGSVSQICALLQLYFCGPNVIRHFFCDISQLLNLSCSDAFFVQVLLAILTMCFGIANALATMLSYGFIVLSILKITSAKGRSKAFNTCASHLTAVSLFYSTAIFVYLRSSSGGSSSFDRFASVFYTVVIPMLNPLIYSLRNKEIKDAMKRLQKKKICS
Protein: CD59 glycoprotein (MAC-inhibitory protein) (MAC-IP) (Membrane attack complex inhibition factor) (MACIF) (Protectin) (CD antigen CD59) (P27274)
Organism: Rattus norvegicus (Rat)
Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Decay accelarating factor 1, isoform CRA_d.
- Membrane cofactor protein
- Membrane cofactor protein
- Complement component C9
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- Complement component receptor 1-like protein
- Plasma protease C1 inhibitor
- Complement component C8 beta chain
- Aa1018
- Complement C4
Sequence:
MRARRGFILLLLLAVLCSTGVSLRCYNCLDPVSSCKTNSTCSPNLDACLVAVSGKQVYQQCWRFSDCNAKFILSRLEIANVQYRCCQADLCNKSFEDKPNNGAISLLGKTALLVTSVLAAILKPCF
Protein: ATP-dependent DNA helicase fml1 (EC 3.6.4.12) (FANCM-like protein 1) (Q9UT23)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinantion during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. FANCM-MHF also promotes non-crossover recombination in meiotic cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Inner kinetochore subunit mhf1
- ATP-dependent DNA helicase srs2
- Inner kinetochore subunit mhf2
- Crossover junction endonuclease mus81
- DNA repair protein rhp51
- F-box DNA helicase protein 1
- DNA topoisomerase 3
- ATP-dependent DNA helicase hus2/rqh1
- Uncharacterized protein C553.01c
- Serine/threonine-protein kinase mph1
Sequence:
MSDDSFSSDEDWDELDTQVVDKIENEYHNNTIGLNGYSVDEYFDANDSNRYRLQHELDESAAQQWVYPINVSFRDYQFNIVQKALFENVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTKPLVTQQMEACYKITGIPKSQTAELSGHVPVTTRNQYYQSRNVFFVTPQTILNDIKHGICDRTRISCLVIDEAHRSTGNYAYVEVVHLLSLSNKNFRILALSATPGNKLEAIQNVIDSLHISRIEIRTENSIDISQYVQKKEVDFFPVDLSAEITDIRDRFSSILEPMLQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNFPANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKLREVEEECFVGRSGYKKRIINHENYRPLMDDIEILLRDQSFVGHPKLEHLERIVTEYFEKEQTKDTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVRKAAGMSQKLQNETVKQFQKGEVNTLIATSIGEEGLDIGEVDMIICYDASASPIRMLQRMGRTGRKRKGYIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEKFRPVCDKRVIEIPKENEEVVVAPKKVQLRTKIKKKFFMPENALNGFITASALGKPKRALAKSEESPFEICPVTYSIEQEKKLEKYKRVCLRGLDIHRNRRLSQLSVTGRIPHSLATKSIHSFLKHLNTIDSQKAQEWRREINNQFQVSNINSTDRDTKQPKMHDFRQPLHPNPMTTLKRKGQHNSFSYDKSTLFYDNNNNLEEDLPDVNISISSRNEEASKTKPFDDRQQRLQQLVEKRKRMKGMLI
Protein: Olfactory marker protein (Olfactory neuronal-specific protein) (P47874)
Organism: Homo sapiens (Human)
Function: May act as a modulator of the olfactory signal-transduction cascade.
Subcellular location: Cytoplasm.
Interaction partners:
- Protein O-mannosyl-transferase TMTC1
- Cyclic nucleotide-gated channel alpha-2
- Neuromodulin
- Unconventional myosin-VIIa
- Adenylate cyclase type 3
- Protein BEX1
Sequence:
MAEDRPQQPQLDMPLVLDQGLTRQMRLRVESLKQRGEKRQDGEKLLQPAESVYRLNFTQQQRLQFERWNVVLDKPGKVTITGTSQNWTPDLTNLMTRQLLDPTAIFWRKEDSDAIDWNEADALEFGERLSDLAKIRKVMYFLVTFGEGVEPANLKASVVFNQL