wanglab/gogpt-training-data huggingface dataset:
Protein: Tyrosine-protein kinase receptor (EC 2.7.10.1) (F1LRZ0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Pleiotrophin
- Midkine
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- GTPase NRas
- Echinoderm microtubule-associated protein-like 4
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- GTPase HRas
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
Sequence:
MGALGFLWLLPPLLLTAASYSGAATDQRAGSPASGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPQPPSPSEPGAGGLEARGSLALDCDPLLRLLGPSPGISWAEGASSPSPEAAPTLSRVLKGGSVRKLRRAKQLVLELGEETILEGCIGPPEEAAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASEVGREGRLSTAIRASQPRLLFQIFGTGHSSLESPSEMPSPPGNFLWNLTWTMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHTHGNQSWSWRRVPSEEASRMNLLDGPEAEHLKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKHGWTVLHGRVGRPENPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQNCAQGEDEGQLCSKLPAGFYCNFEDGFCGWTQSPLSPRVPRWQVKTLKDTHSQGHQGHALLLSTTDDPTSESATVTSATFPAPMKSSPCELRMSWLIRGVLKGNVSLVLVENKTGKEQSRTVWHVATNEGLSLWQWTVLSLLDVTDRFWLQIVTWWGPGSRATVAFDNISISLDCYLTISGEEKMSLNAVPKSRNLFEKNPNKEPKPWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGSEGPLRGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDTLYILVGQQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQSAKHEEASSAPQPSALAAPGPLVKKPSGAGAGAGAGPVPRGAADRGHVNMAFSQPNPPPELHKGPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRRAEAALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAAPGDTVLKSKTKVTQPGP
Protein: Nicotinamide nucleotide adenylyltransferase 3 (Q5XIF7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGKYQVIEGIISPVNDSYGKKDLVASHHRVAMARLALQTSDWIRVDPWESEQAQWMETASSRGAAQIRGPDGWPRPQQNTISLCGTA
Protein: RNA ligase 1 (EC 6.5.1.3) (Gene product 63) (gp63) (Rnl1) (P00971)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Involved in countering a host defense mechanism which, following viral infection, activates the host anticodon nuclease and shuts off viral translation. Repairs 5'-PO4 and 3'-OH groups in the cleaved host tRNA. The nick ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nicked duplex nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated nicked intermediate. In step 3, the RNA ligase directs the attack of the nick 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP (By similarity).
Interaction partners:
Sequence:
MQELFNNLMELCKDSQRKFFYSDDVSASGRTYRIFSYNYASYSDWLLPDALECRGIMFEMDGEKPVRIASRPMEKFFNLNENPFTMNIDLNDVDYILTKEDGSLVSTYLDGDEILFKSKGSIKSEQALMANGILMNINHHRLRDRLKELAEDGFTANFEFVAPTNRIVLAYQEMKIILLNVRENETGEYISYDDIYKDATLRPYLVERYEIDSPKWIEEAKNAENIEGYVAVMKDGSHFKIKSDWYVSLHSTKSSLDNPEKLFKTIIDGASDDLKAMYADDEYSYRKIEAFETTYLKYLDRALFLVLDCHNKHCGKDRKTYAMEAQGVAKGAGMDHLFGIIMSLYQGYDSQEKVMCEIEQNFLKNYKKFIPEGY
Protein: SKP1-like protein 11 (AtSK11) (O49484)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity). Plays a role during early flowers reproductive development.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-1
- Cullin-2
- Putative cullin-like protein 2
- Putative cullin-like protein 1
- Cullin-like protein 3
- RING-box protein 1a
- RING-box protein 1b
- F-box protein 7
- Adagio protein 3
- Coronatine-insensitive protein 1
Sequence:
MSSKMIVLMSSDGQSFEVEEAVAIQSQTIAHMVEDDCVADGIPLANVESKILVKVIEYCKKHHVDEANPISEEDLNNWDEKFMDLEQSTIFELILAANYLNIKSLLDLTCQTVADMIKGKTPEEIRSTFNIENDFTPEEEEAVRKENQWAFE
Protein: Rho-GAP domain-containing protein (H2KZV4)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Arf-GAP with ANK repeat and PH domain-containing protein cnt-2
- Rab-GAP TBC domain-containing protein
Sequence:
METPVPKPRTKFEPSSPEPTLPPRPPVKPPRAVANSTAVQNFGNVLGELRLNLNETISSQDPPGIGFIEVSPGTSMSPPQRHAPPPPRPPPPAGWKQHPVIPERIQLNRPLPSLPIDVSLTPVYSEPSTSSPSSTNCYENHNSSVVENPLYLSLDTYRSISGITPSPSNAPTTSPDCDELREWLTEEEENESCSSSRPENLNASIPAPIPGDDSRPSIDSEENPYTPCPRRSDYDNSEFIGSTIDPFDDSFYTDNTTNNSHQNLYVSPQFVKEKTKSECDRYENVVEICSSPDPPPTHLYVNVPPIYPSADNIISSESDDVFRDEGKMKIDGSSITFVGFVSLTSSKKEKRLHCRLRNMQLSFHDDEDSTEPSNGTFDIKGIYLFRHMASDTPYILIHVGEKRNVISFIPEDPPNLWMFFLSEAWLSLNYGLTSVLRDADELTICGITWIKHGTTGEWKICSAGINGLTLHYMLVDAKDRIYNRNSERSDAGTSFMSTVGSIIGDELVEVDLRKVMTMRERIDKSEFCPNARHKRGPFSITLHGVTLYIDSRDDSTTSHWYEAIEALLKRPATRLENLRLTGDNIPVIVDKCIRFVSAYGMKCEGIYRRNGKVTEAKTILTKLTEDPVGYYPVHENDETVYAVADVLRQFFRKLDAPLFPSSSQADLFDLATESQSDELCARYAQLINTFELVHRSTLKKLIGHLKNVSEHAQENRASVENLAKVFAASLFLTDAMDEKVFSESYNHQINVLIHLTTGYDVVFQISIEEELSRQMVNDAEKKSFNAKKPSPDFIVAIHVWEKENRPFNVKMSLASEEVCREAIAKRGFDGPPDSPYAIFECLAGGNLIRRLPNAQKMSKCVLQWIDWNCKDAYLLFDHDKYQFNGTDMSCFTGKIKIAEPGSRTFKSYEVKIENGTSIVAFRNEKLWKAWPMDDSIWYVGTEPTRKSPNLFNATMICSTKTGYSSSRFPGFCFSFKEETDRNRWLTALSHFTKSIDSEPLVYI
Protein: Mechanosensory protein 3 (P09088)
Organism: Caenorhabditis elegans
Function: Transcription factor. Specifies differentiation of the set of six touch receptor neurons (TRNs). May positively modulate expression of both its own gene and also of homeobox ARX homolog alr-1 in TRNs, forming a positive feedback loop with alr-1, thereby restricting the variability of expression of mec-3. Required to determine the identity of ALM sensory neurons, acting by interacting with unc-86, thereby preventing unc-86 cooperating with pag-3 to induce BDU-neuron specific genes. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. Promotes outgrowth of lateral dendritic branches on the PVD nociceptive neurons, probably acting both directly, and upstream of zinc finger protein egl-46.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor unc-86
- Serine protease inhibitor 1 protein
- Degenerin mec-4
- Tubulin beta-1 chain
- AMP-binding domain-containing protein
- Degenerin mec-10
- Alpha-tubulin N-acetyltransferase 1
- Zinc finger protein GFI1 homolog pag-3
- Transmembrane protein
Sequence:
MEMLESKPLSAISMVIDSIGVDHENQNKCNCCNEQIYDRYIYRMDNRSYHENCVKCTICESPLAEKCFWKNGRIYCSQHYYKDHSIHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCSLCGRHLSPGEQILVDDTMMTVSCMSHYPPQMDDNAPGAIGSAVDIPSCSTENPIAPYPIDESFSSAFQVKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIKQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDTTDFNAFCGNFEEEDDED
Protein: Zinc finger protein ZFEND (Q923T4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSSSFDLDPDPDVIGPVPLVLDPSNDTPSPAAPDVDSLPSGLTATPEILATSPAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAAAAAAAAGLGLGSGLSPVSMMRPGQISFLGPDAVSVLESGLGLSSGASSARSSAPTSVLGSLQNPILQTHSGSISSPDLVLSSDPKPGHVADPDVVPSPDQESDPSPNPDLVPSPDPKPKSQTDPCSPTHDSSSPALPTGESPKWVKEEGALLGPDG
Protein: Beta-toxin Cb3 (C0HLR5)
Organism: Centruroides baergi (Scorpion) (Centruroides nigrovariatus baergi)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and reduces peak current and shifts the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Has an inhibitory effect on voltage-gated sodium channels hNav1.1/SCN1A, hNav1.2/SCN2A, hNav1.4/SCN4A and hNav1.6/SCN8A. Reduces the peak current of hNav1.5/SCN5A but does not shift its voltage of activation. Also affects the inactivation processes of hNav1.1/SCN1A, hNav1.4/SCN4A, hNav1.5/SCN5A and hNav1.6/SCN8A. This toxin is active against mammals and lethal to mice.
Subcellular location: Secreted {ECO:0000269|PubMed:32479835}.
Interaction partners:
Sequence:
KEGYIVNYYDGCKYPCVKLGDNDYCLRECRLRYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCL
Protein: Neuronal pentraxin-2 (NP2) (Neuronal activity-regulated pentraxin) (Neuronal pentraxin II) (NP-II) (P97738)
Organism: Rattus norvegicus (Rat)
Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
Subcellular location: Secreted.
Interaction partners:
- Glutamate receptor 4
Sequence:
MLALLTAGVALAVAAGQAQDNPIPGSRFVCTALPPEAARAGCPLPAMPMQGGALSPEEELRAAVLHWRETVVQQKETLGAQREAIRELTSKLARCEGLAGGKARGTGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLELQLHTNASNAGLPSDFREVLQRRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTENTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL
Protein: Aminopeptidase (EC 3.4.11.-) (Q55CT4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MCKYNDHKYLVEKVDRLVLPENVVPIKYDLHLKPNLKEFTFKGEETITVQVKQPTKTITIHSIEIEIQSASIKSSSSSQSSKSITFYEPEEVVIFEFENELSVGEYCLSLVFTGLLNDKLKGFYRSKYTVKGEDRYLATTQFEATDARRSFPCFDEPAHKAVFNITLTVSECHTAISNMEEKSITPNNDGTKTYIFEQTPIMSTYLVAYIVGDLEYIEGKTKGGIRVRVYKAKGVEGESDFALDTGIRAMDYFIDYFNVPYPLTKCDHVAVPDFAAGAMENWGLITYRDVILLTSDKTTLATKQDIVGVIGHELAHQWFGNLVTMEWWSQLWLNEGFATFMGYLVTDYLYPKWNVFLEFSQSYRNSALSLDALDNSHAIEVPVRSSAEISEIFDDISYNKGSCVIQMVESRFGESFRKGLHHYLTKHSYKNTITEDLWASISHTSGADVDSFVRSFTKYPGYPVVSIQETEKEGEFSLTQKKFRSDGQVEEKSDDPIWNCFIKFQTKNGPFEFTLTKKSDTVTIPNYKKGDWLKPNYGQCGYYRIAYTSELIKALVPVIESLELPAQDRLGLLSDCYYLCKNGSTPISSYMDLVFSYHNETDSDVWTFIIKSLDEISELSFDQTYKTDLEEMIRKLLKPLSQRLGFEVKSGESSSDTLLRNKVNSYLGILGDKEIVAEARKRFEQFKVDQSSLPSDIRSSVLVTVVKNGSEAEQQEIINRYLASNDIAEKSSLLSVVCKSPSSALVLKALEFSVSKDVRTCESYMLWRVGNEFKPVVWKYFTENFKSINETFNQNVLFAYMISFALSSKMTDQQLQQVEDFFKQNPVAIADRSIKQDLEQIRNNTKWFNSFNKDLLNWIKK
Protein: Granulocyte-macrophage colony-stimulating factor (Colony-stimulating factor) (I3L8Q3)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MWLQNLLLLGTVVCSISAPTRPPSPVTRPWQHVDAIKEALSLLNNSNDTAAVMNETVDIVCEMFDPQEPTCVQTRLNLYKQGLRGSLTRLKSPLTLLAKHYEQHCPLTEETSCETQSITFKSFKDSLNKFLFTIPFDCWGPVKK
Protein: Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta) (Q0VB07)
Organism: Mus musculus (Mouse)
Function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Peptidoglycan recognition protein 3
Sequence:
MLSWLLVFSILVLLAQGVSSWENPQTDQVSEGLQQLFGNISQLFEKGILGRDDVFTMVSREEWGAEAIGCSSKLSRPVDVLVIHHIPGLECHNKTVCSQKLRELQAYHIHNSWCDVAYNFLVGDDGRVYEGVGWNVQGSHDQGYKNISLGVAFFGTQEGHSPSPVALSAMKGLISYAVKKGHLSSKYIQPLLAKSEDCLVPPQKGKQKKACPHIVPRSVWGARDSHCSRMTLPAKYAIILHTAGRTCSQPDECRLLVRDLQSFFMNRLNACDIGYNFLVGQDGGVYEGVGWNNQGSKTDSYNDISLSITFMGTFTGSPPNAAALEAAQDLIRCAVVKGYLTPNYLLMGHSDVSNTLSPGQALYNIIKTWPHFKH
Protein: tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) (Q9BUB4)
Organism: Homo sapiens (Human)
Function: Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Interaction partners:
- Probable inactive tRNA-specific adenosine deaminase-like protein 3
- tRNA-specific adenosine deaminase 2
- Lysine--tRNA ligase
- Alanine--tRNA ligase, cytoplasmic
Sequence:
MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLEPGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQVGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQNVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISWSAVPEQPLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQFK
Protein: Serine/threonine-protein phosphatase PP1-2 (EC 3.1.3.16) (Suppressor protein SDS21) (P23880)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.
Interaction partners:
- Protein phosphatase 1 regulatory subunit SDS22
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- Polyadenylation factor subunit 2
- Uncharacterized RING finger protein P8B7.15c
- Serine/threonine-protein phosphatase PP1-1
- Set1 complex component swd2
- Endoribonuclease ysh1
- Cleavage factor two protein 2
- Protein cft1
- Serine/threonine-protein phosphatase PP-Z
Sequence:
MDYDIDAIIEKLVKARNGKPSKQVQLSDAEIRYLCTTSRSIFLSQPMLLELEAPLKICGDIHGQYSDLLRLFEYGGYPPDANYLFLGDYVDRGKQSLEVICLLFAYKIKYPENFFLLRGNHEFASINRIYGFYDECKRRYSIKLWKTFTDCFNCMPVAAVIDEKIFCMHGGLSPDLNSLDQIQRIIRPTDIPDTGLLCDLVWSDPEKDLTGWGENDRGVSYTFGADVVSRFLQKHDLDLICRAHQVVEDGYEFFGKRQLVTIFSAPNYCGEFDNVGAMMSVNEDLLCSFQILKPAEKRQRVSQSSIKESKSATNSLKKSKNN
Protein: Non-specific lipid transfer protein GPI-anchored 1 (AtLTPG-1) (Protein LTP-GPI-ANCHORED 1) (Q9C7F7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lipid transfer protein that, together with LTPG2, binds to lipids and functions as a component of the cuticular lipid export machinery that performs extensive export of intracellular lipids (e.g. C29 alkane) from epidermal cells to the surface to build the cuticular wax layer and silique walls. Involved in the establishment of resistance to the necrotrophic fungal pathogen Alternaria brassicicola. Contributes to pre-invasive defense against some non-host powdery mildew pathogens by preventing the penetration of the epidermal cell wall by the fungal agents (e.g. Blumeria graminis f. sp. hordei (Bgh)). Maybe involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19321705, ECO:0000269|PubMed:22891199, ECO:0000269|PubMed:23505340}; Lipid-anchor, GPI-anchor {ECO:0000255}. Secreted, cell wall {ECO:0000269|PubMed:19366900}. Endoplasmic reticulum {ECO:0000269|PubMed:19366900}. Golgi apparatus {ECO:0000269|PubMed:19366900}. Note=Targeted to the plasma membrane via the vesicular trafficking system (PubMed:19321705, PubMed:22891199). Localized to the plasma membrane on all faces of epidermal cells (PubMed:19366900). Also detected in the periclinal cell wall (PubMed:19366900). In young meristematic cells, observed in plasma membrane and in puncta resembling the Golgi (PubMed:19366900). Localized to papillae at the sites of Blumeria graminis f. sp. hordei (Bgh) penetration (Bgh) (PubMed:30102837). {ECO:0000269|PubMed:19321705, ECO:0000269|PubMed:19366900, ECO:0000269|PubMed:22891199, ECO:0000269|PubMed:30102837}.
Interaction partners:
- ABC transporter G family member 11
- Non-specific lipid-transfer protein 1
- Non-specific lipid-transfer protein 5
- ABC transporter G family member 12
- Non-specific lipid transfer protein GPI-anchored 6
- 3-ketoacyl-CoA synthase 6
- Probable pectinesterase/pectinesterase inhibitor 44
- Serine carboxypeptidase-like 43
- Very-long-chain enoyl-CoA reductase
- Very-long-chain aldehyde decarbonylase CER1
Sequence:
MKGLHLHLVLVTMTIVASIAAAAPAAPGGALADECNQDFQKVTLCLDFATGKATIPSKKCCDAVEDIKERDPKCLCFVIQQAKTGGQALKDLGVQEDKLIQLPTSCQLHNASITNCPKLLGISPSSPDAAVFTNNATTTPVAPAGKSPATPATSTDKGGSASAKDGHAVVALAVALMAVSFVLTLPRHVTLGM
Protein: Probable galacturonosyltransferase-like 4 (EC 2.4.1.-) (Galactinol synthase 9) (AtGolS9) (GolS-9) (Q9M8J2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in pectin and/or xylans biosynthesis in cell walls.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Nuclear poly
- Hydroxyproline O-galactosyltransferase GALT4
- Galactinol synthase 5
- Galactinol synthase 10
- Galactinol synthase 7
- Galactinol synthase 6
Sequence:
MASRSLSYTQLLGLLSFILLLVTTTTMAVRVGVILHKPSAPTLPVFREAPAFRNGDQCGTREADQIHIAMTLDTNYLRGTMAAVLSLLQHSTCPENLSFHFLSLPHFENDLFTSIKSTFPYLNFKIYQFDPNLVRSKISKSIRQALDQPLNYARIYLADIIPSSVDRIIYLDSDLVVVDDIEKLWHVEMEGKVVAAPEYCHANFTHYFTRTFWSDPVLVKVLEGKRPCYFNTGVMVVDVNKWRKGMYTQKVEEWMTIQKQKRIYHLGSLPPFLLIFAGDIKAVNHRWNQHGLGGDNFEGRCRTLHPGPISLLHWSGKGKPWLRLDSRKPCIVDHLWAPYDLYRSSRHSLEE
Protein: Formin like 3 (F8W1F5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
Protein: Regulatory protein NPR1 (BTB/POZ domain-containing protein NPR1) (Non-inducible immunity protein 1) (Nim1) (Nonexpresser of PR genes 1) (Salicylic acid insensitive 1) (Sai1) (P93002)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10662863, ECO:0000269|PubMed:11148282, ECO:0000269|PubMed:12837250, ECO:0000269|PubMed:26269953}. Nucleus {ECO:0000269|PubMed:10662863, ECO:0000269|PubMed:11148282, ECO:0000269|PubMed:12837250, ECO:0000269|PubMed:26269953}. Nucleus, nuclear body {ECO:0000269|PubMed:26269953}. Note=Accumulation in nucleus after induction by salicylic acid (SA) treatment or after pathogen infection (PubMed:10662863, PubMed:11148282, PubMed:12837250). Accumulates in nuclear bodies when sumoylated (PubMed:26269953). {ECO:0000269|PubMed:10662863, ECO:0000269|PubMed:11148282, ECO:0000269|PubMed:12837250, ECO:0000269|PubMed:26269953}.
Interaction partners:
- Transcription factor TGA2
- Transcription factor TGA3
- Protein NIM1-INTERACTING 1
- Transcription factor TGA1
- Transcription factor TGA5
- Protein NIM1-INTERACTING 2
- Transcription factor TGA6
- Transcription factor TGA4
- Protein NIM1-INTERACTING 3
- Transcription factor TGA7
Sequence:
MDTTIDGFADSYEISSTSFVATDNTDSSIVYLAAEQVLTGPDVSALQLLSNSFESVFDSPDDFYSDAKLVLSDGREVSFHRCVLSARSSFFKSALAAAKKEKDSNNTAAVKLELKEIAKDYEVGFDSVVTVLAYVYSSRVRPPPKGVSECADENCCHVACRPAVDFMLEVLYLAFIFKIPELITLYQRHLLDVVDKVVIEDTLVILKLANICGKACMKLLDRCKEIIVKSNVDMVSLEKSLPEELVKEIIDRRKELGLEVPKVKKHVSNVHKALDSDDIELVKLLLKEDHTNLDDACALHFAVAYCNVKTATDLLKLDLADVNHRNPRGYTVLHVAAMRKEPQLILSLLEKGASASEATLEGRTALMIAKQATMAVECNNIPEQCKHSLKGRLCVEILEQEDKREQIPRDVPPSFAVAADELKMTLLDLENRVALAQRLFPTEAQAAMEIAEMKGTCEFIVTSLEPDRLTGTKRTSPGVKIAPFRILEEHQSRLKALSKTVELGKRFFPRCSAVLDQIMNCEDLTQLACGEDDTAEKRLQKKQRYMEIQETLKKAFSEDNLELGNSSLTDSTSSTSKSTGGKRSNRKLSHRRR
Protein: Small ribosomal subunit protein eS8z (40S ribosomal protein S8-1) (Q93VG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS19z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS10z
- Small ribosomal subunit protein eS26z
- Small ribosomal subunit protein eS1y
- Large ribosomal subunit protein eL15z
- Small ribosomal subunit protein eS6y
Sequence:
MGISRDSIHKRRATGGKQKQWRKKRKYEMGRQPANTKLSSNKTVRRIRVRGGNVKWRALRLDTGNYSWGSEATTRKTRVLDVVYNASNNELVRTKTLVKSAIVQVDAAPFKQWYLSHYGVELGRKKKSASSTKKDGEEGEEAAVAAPEEVKKSNHLLRKIASRQEGRSLDSHIEDQFASGRLLACISSRPGQCGRADGYILEGKELEFYMKKIQKKKGKGAA
Protein: DNA-directed RNA polymerase subunit, putative (EC 2.7.7.6) (Q585J9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Plastid-encoded RNA polymerase subunit alpha
- Plastid-encoded RNA polymerase subunit alpha
- DNA-direcetd RNA polymerase II, subunit 9, putative
- DNA-dependent RNA polymerases, putative
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II, putative
Sequence:
MSERDEDEVDRLSLSIGDEHESVAQSDDERSDAGAGVVVSGPAPVRGSAKRRDDRDRVTAPVLTKYERARILGTRALQISMNAPVLVALEGETDPLTIAQKELREGVIPLIIRRVLPDNTYEDWRICELDVDFDRPVDERYTNI
Protein: Histone H4 (P83865)
Organism: Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P84040}. Chromosome {ECO:0000250}.
Interaction partners:
Sequence:
MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRXXXTLYGFGG