wanglab/gogpt-training-data huggingface dataset:
Protein: ABC transporter-related protein (Non-transporter ABC protein AbcF1) (Q8T6B8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL23
- eIF-2-alpha kinase activator GCN1
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL30
Sequence:
MVSKEIKSVIEKTLGDKTKDIDETIIDYISGVFEDEGVNSDMDELTEILSPLLLDTCFADDESGVNSAINGIVEALVNEKLITIKQKQTITQLSQPVALQRLDDRVGAAVSWMKAEEGISIVNKDQLEANEKRYNARKEARLAKEERKKLRQNAALAALNSLKEQQTMMASTIRGTNQSRDIHVDAFNVTYGKNDLIINSDLNLNYGRKYGLIGRNGTGKTTLLRHIASREIGIDNNLSILHVEQEVNGNETTVIECVLEADVERDRLLKEEKRLNALPESEKNNLSEKLNSIYEKLNHIDAHTAESRAAAILSGLGFTEEMQQQPTKSFSGGWRMRISLARALFIQPDVLLLDEPTNHLDLFACLWLESYLVNWNRTLVIVSHQREFLNAVCTDIMHLNNKKIDYYKGNYSVFERTRSDRLKAQQRSFEAQQSQKKHIQAFIDRFRYNAKRAKMAQSRIKQLERMEDIGEVLDDPTVTLQFLEPEPLAPPILQFQDVSFGYTPDKLLFKNLNLGIDMGSRVALVGANGAGKTTLLRLLCGELEETNGLVIRNGKLRFSRFSQHFVDQLDLSKSPLDNFLAKYPGTTAQTARSHLGKFGLSGDIALRTVNTLSGGQKSRVVLAQISYTKPHILLLDEPSNHLDIDTVDALCHALNVFEGGILLVSHDERLISLVCDEIWYFDGEEGEPKEVKNFDGDWNDYKKAIWNL
Protein: Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29) (Q9DB91)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 11
Sequence:
MAAPQPQAAAVSSASGVSGPGSAGGPGPQQQPQPTQLVGSAQSGLLQQQQQDFDPVQRYKMLIPQLKESLQTLMKVAAQNLIQNTNIDNGQKSSDAPLQRFDKCLEEFYALCDQLELCLRLAHECLSQSCDSAKHSPTLVPTATKPDAVQPDSLPYPQYLAVIKAQITCAKDIHTALLDCANKVTGKTTAPSTGPGGSL
Protein: Polyadenylation factor subunit 2 (P42841)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Integral and essential component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May bridge the CPF and CFIA complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:12819204, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Poly
- Protein MPE1
- Protein PTI1
- COMPASS component SWD2
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Pre-tRNA-processing protein PTA1
- Serine/threonine-protein phosphatase PP1-2
- mRNA 3'-end-processing protein YTH1
- Pre-mRNA polyadenylation factor FIP1
- Endoribonuclease YSH1
Sequence:
MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI
Protein: LiPid Depleted (Q22641)
Organism: Caenorhabditis elegans
Interaction partners:
- Mitochondrial proton/calcium exchanger protein
- PRELI/MSF1 domain-containing protein
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import receptor subunit TOM22 homolog
- Probable mitochondrial import inner membrane translocase subunit tin-44
- Large ribosomal subunit protein mL44
- Probable NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- Complex I-B12
- Mitochondrial import inner membrane translocase subunit tim-16
Sequence:
MSGLSHAGRQVARIAVRQASSHSHDSHAVWKEINRLGSEGKWDNVNNMPKMFLFGEAKQETTAAYRAINKDPDFFRQSPYGQYLKIVWRLALLFGIIKAGTVVYDFAVPEEQRLKYKYRNHGHHGHDDAHD
Protein: Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) (Q86TG7)
Organism: Homo sapiens (Human)
Function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region. Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1. Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
Subcellular location: Extracellular vesicle membrane {ECO:0000269|PubMed:34413232}. Cytoplasm {ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:17621626}. Nucleus {ECO:0000269|PubMed:12810624}. Note=Forms virion-like extracellular vesicles that are released from cells (PubMed:34413232). Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line (PubMed:12810624). {ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:34413232}.
Interaction partners:
- Epsilon-sarcoglycan
- Paternally-expressed gene 3 protein
- Mesoderm-specific transcript homolog protein
- Retrotransposon Gag-like protein 8B
- Retrotransposon Gag-like protein 8A
- Retrotransposon Gag-like protein 8C
- Centrosomal protein of 290 kDa
- Growth factor receptor-bound protein 10
- Protein LDOC1
- Zinc finger protein PLAGL1
Sequence:
MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPAGKLPGPAVEGPSATGPEIIRSPQDDASSPHLQVMLQIHLPGRHTLFVRAMIDSGASGNFIDHEYVAQNGIPLRIKDWPILVEAIDGRPIASGPVVHETHDLIVDLGDHREVLSFDVTQSPFFPVVLGVRWLSTHDPNITWSTRSIVFDSEYCRYHCRMYSPIPPSLPPPAPQPPLYYPVDGYRVYQPVRYYYVQNVYTPVDEHVYPDHRLVDPHIEMIPGAHSIPSGHVYSLSEPEMAALRDFVARNVKDGLITPTIAPNGAQVLQVKRGWKLQVSYDCRAPNNFTIQNQYPRLSIPNLEDQAHLATYTEFVPQIPGYQTYPTYAAYPTYPVGFAWYPVGRDGQGRSLYVPVMITWNPHWYRQPPVPQYPPPQPPPPPPPPPPPPSYSTL
Protein: Zinc finger protein 229 (Q9UJW7)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
METLTSRHEKRALHSQASAISQDREEKIMSQEPLSFKDVAVVFTEEELELLDSTQRQLYQDVMQENFRNLLSVGERNPLGDKNGKDTEYIQDEELRFFSHKELSSCKIWEEVAGELPGSQDCRVNLQGKDFQFSEDAAPHQGWEGASTPCFPIENFLDSLQGDGLIGLENQQFPAWRAIRPIPIQGSWAKAFVNQLGDVQERCKNLDTEDTVYKCNWDDDSFCWISCHVDHRFPEIDKPCGCNKCRKDCIKNSVLHRINPGENGLKSNEYRNGFRDDADLPPHPRVPLKEKLCQYDEFSEGLRHSAHLNRHQRVPTGEKSVKSLERGRGVRQNTHIRNHPRAPVGDMPYRCDVCGKGFRYKSVLLIHQGVHTGRRPYKCEECGKAFGRSSNLLVHQRVHTGEKPYKCSECGKGFSYSSVLQVHQRLHTGEKPYTCSECGKGFCAKSALHKHQHIHPGEKPYSCGECGKGFSCSSHLSSHQKTHTGERPYQCDKCGKGFSHNSYLQAHQRVHMGQHLYKCNVCGKSFSYSSGLLMHQRLHTGEKPYKCECGKSFGRSSDLHIHQRVHTGEKPYKCSECGKGFRRNSDLHSHQRVHTGERPYVCDVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFSYSSGLLIHQRVHTGEKPYRCQECGKGFRCTSSLHKHQRVHTGKKPYTCDQCGKGFSYGSNLRTHQRLHTGEKPYTCCECGKGFRYGSGLLSHKRVHTGEKPYRCHVCGKGYSQSSHLQGHQRVHTGEKPYKCEECGKGFGRNSCLHVHQRVHTGEKPYTCGVCGKGFSYTSGLRNHQRVHLGENPYK
Protein: Keratin-associated protein 21-2 (Q3LI59)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 21-3
- Keratin-associated protein 21-1
Sequence:
MCCNYYRNCCGGCGYGSGWSSGCGYGCGYGCGYGSGCRYGSGYGTGCGYGCGYGSGCGYGCGYSSSCCGYRPLCYRRCYSSCY
Protein: Dopamine receptor D2 (H0YPR8)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- G protein subunit alpha i3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Neuronal calcium sensor 1
- Dopamine receptor D4
- Adenosine receptor A2
- G protein subunit beta 4
- G protein subunit beta 1
- catechol O-methyltransferase
Sequence:
MDPLNLSWYDGDRNWSRALNASEAAQRPHYNYYAMLLALLIFIIVFGNVLVCMAVSRERALQTTTNYLIVSLAVADLLVATLCMPWVVYMEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAVVWVLSFAISCPLLFGLNNTDEKECIIGNPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLRRRRKRVSTKRSSHVLDSDTQAPLKQPWEGGEEWPCQRIPPHSQGLRDPLPAQRQDEELAQGRDQEETVPAEGEESHPDAGHRARCFHHLLAPLLHHSHPEHALRLQHPAGHVQRLHVARLRQQRCQPDYLHHLQHRVSQGFHEDPPLLKPQTAPAFFLGWEEEAMPFTHGGAAGDGLELLSRAALGARAPGGDGTRQEGLSPRWVTSGPAPRALFRATLAPCWKWKCENRGALARFSPVAARPGVHWTRWTQSGHGASRR
Protein: Zinc finger Ran-binding domain-containing protein 2 (E7F1Q7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037956}.
Interaction partners:
- Cocaine-and amphetamine-regulated transcript protein-like 1
- CD59B glycoprotein
- Splicing regulatory glutamine/lysine-rich protein 1
Sequence:
MSGKSFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCGNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENLVYNEREESDGEYDEFGRIKKKFRGKTKKDSDKKEEPKKVDQDDEEEDDDDEDGDLSKYKLDDDDEDDDDDDDDEDDADLSKYDLDDGDEKKGSHSGSSRSSSRSSSSSSRSRSRSRSRSSSSSRSRSRSRSKSRSSSRSGKGSASSKKRSRSPSSSPEGGQKRSRSRSSSGGRKKRRARSHSSERRRGSSGSSHSGSSSKQN
Protein: Major urinary protein 18 (A0A8I5Y2J8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLLLLLLCLGLTLVCGHAEEASFERGNLDVDKLNGDWFSIVVASNKREKIEENGSMRVFMQHIDVLENSLGFKFRIKENGECRELYLVAYKTPEDGEYFVEYDGGNTFTILKTDYDRYVMFHLVNFKNGETFQLMELYGRTKDLSSDIKEKFEKLCVAHGITRDNIIDLTKTDRCLKARG
Protein: GTPase-GDP dissociation stimulator arz1 (O60077)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). May be involved in the control of polarized cell growth via CDC42-mediated signaling (By similarity). May also be involved in the control of cell-wall organization via RHO1-mediated signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Zinc finger protein zfs1
- Transcription factor cbf12
Sequence:
MTASDTVYLFQSLADRSKNPQERSLFRNYISEALELLRETPSSPTVVHEQCFRFLANSCSDNNENRAAFFNLGGIDVLKPYCSKDNEYSALAFAVIHNCILDSREYRAQVADAQILNLAITYWIDWQHKLKAPFFNMLSFVCEMLYPFCKDCSLVFMGLQLLPSMVREGIDPFTIFAKAFDNSLVCVSFAQNPSMLIDSIDLVRNMPDFTKKTDMLNLFPRIAEHDAVLSTSLHADPQFLDFLESCFRSDDSNSITMASLFIGNLVRRDDIAKQLMQKDFLNMLISCIMQEKDVDGNVERVYACCAALRHFMIPVSSRAHFAPTAILLQEKLASSRFTQLHYISASMIRLSMPYILCELADHPERFYKLKDWSKSPDFNLALESNRTLLGFVKHYLTVPKSKEKISAFFKNNINLFEESVVTVLSTESKYPIVIGEAVFVAILMIKHGYANVAQTIIASPVYEALKSYRDDPNLAYQLKQNVRSLLVLVEHR
Protein: HTH-type transcriptional regulator ArgP (Q9HW38)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Controls the transcription of genes involved in arginine and lysine metabolism.
Interaction partners:
- Probable transporter
- Transcriptional regulator CynR
- Probable transcriptional regulator
- Acetylpolyamine amidohydrolase 2
- ADP-ribose pyrophosphatase
- Transcriptional repressor NrdR
Sequence:
MILFDYKLLAALAAVVEQGGFERAAQALGLSQSAVSQRIKLLEARVGQPVLVRETPPHPTDLGRRLLNHVQQVRLLEGDLQRWVPNLDEGGAPERLRIALNADSLATWWAAAVGDFCAERRVLLDLVVEDQEVGLKRMRAGEVAGCVCGSARPVAGARSLLLGAMRYRGLASPDFIARHFPRGVEAAALAGVPAIVFGPDDLLQHRFLKDLGVEGGFIHHLCPSSEGFVRLTAGGLGWGLVPERQVQGELARGELVELLPGQVIDVPLYWHYWRNGGELLASLTEHLLARAGDGLVRVSG
Protein: Rho GTPase-activating protein syd-1 (Axon identity specification protein syd-1) (Synapse defective protein 1) (Q86NH1)
Organism: Caenorhabditis elegans
Function: Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1.
Subcellular location: Synapse {ECO:0000269|PubMed:12379863}. Note=Presynaptic terminals. {ECO:0000269|PubMed:12379863}.
Interaction partners:
- Liprin-alpha
- ELKS/RAB6-interacting/CAST family member 2
- Neurabin-1
- Arginine/serine-rich protein PNISR
- Synaptogenesis protein syg-1
- Ras-related protein Rab-3
- Serine/threonine kinase SAD-1
- Major facilitator superfamily
- Neurexin-3-beta
- Rab-3-interacting molecule unc-10
Sequence:
MLISTSLKFLTMLTSNGFGGTNPPKGMPYPPTYLYTEEPQNECCCCWLCRLLCCCSPVDQTASRSRMNASQPPPGGGGRLPDEVFRKITAVDQGQSTLTQSGIQGLSARTLSSEPRGDLVFQLVEIIKKPGQSLGLYLREGNGKDRSDGVFVSRFGDNSELAKYGEVMRPGDEILTINNVEVSMMSIDDVVLILSIPRRLLLRIRYSKSMRHEIISSRSRESERPVVVFHKYDDRRDSETNAPILSQPTSTANTWLGKKSRQQMEEMRNATTSSTLRTHASTSSPRNHFAPRLVNGHSHSIGVPSASTTSHDHQYQRFASEPSDSVSRTARVPPPRLASATVRRTESFNSAPGVSTSAPMYTLPRSSTAVPPPDILGSIPYSARDPLMRSSADLPYDPMTGRLSSSVPTDPLLSRSLCSPILPRTLRQANDSNKSNSLPRRRIMTGGRNVKWRNDVVSTSDLCGEESDGAISAPEYSSPPFSRLTQQQQFRLSNGSPGRTVNDIFSAAEYRNWAGPYDPRGMYGPFPPGQRATRWSHTYGEQRAPRTSSLPGRTVLAQSLVGSPVLPRHPPPIVQDRPSAVFDRYHVSPLMNRRAPLRAAGPGINVDRLSVSSLTGILYVHIVEGRGLKIPEKQKGLTEEMYCVLEVDEQHRARTGVSTIEQKFKWRETFHIDVVNATVSNFFVYSWHPQFRHKLCHKGSLKLLEAFVVDQLNDDRVFALNLEPRGQLIVRIGFHDLQAVFRRTVNPRLNGVFGISLSRLVQRERRDTPIVLTRLIQEIEKRGVDYSGLYVLCGSVEKKKMLRAELESNPLGTELAAESIPDTNVIACLIKDFLRELPEPLISPQIHGMLLEAASVALPNDVQTNRHLVLKIIDCLQLSAKNCLLLVLDHLSTVLCSSPHNGLTPTRLSLIFAPLLFFCLDTFSPYTISPTSKMAAVRTLDINQASSSLQMILSIWPSRVNSESGSDSPATTCQKGGVIAYVSESQC
Protein: Protein Skeletor, isoforms B/C (Q9VGY6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Provides structural support to stabilize and organize the microtubule spindle during mitosis (within embryonic somatic cells) and meiosis (within spermatocytes). The role in mitosis regulation depends on the Ran pathway.
Subcellular location: Cytoplasm, cytoskeleton, spindle. Nucleus, nucleolus. Chromosome. Note=Part of a macromolecular complex forming the spindle matrix. During mitosis, associated with chromatin at interphase, redistributes to the spindle structure at prophase (preceding the formation of the microtubule spindle) through to anaphase. Extends from one end of the spindle to the other during metaphase and anaphase, coaligns with the microtubule spindle.
Interaction partners:
Sequence:
MLAMKDKPWLLLFGLLAALSCLASFGDAAYPYYGTKIGALTRLHHGVSGDVYAVDSRTIFIKKFNYDGEAPAAYFYVGNTARPSNEGAARLRDERGGTASLTRRYRNKDVTLSLPEGKTLRDIKWFSVWCDEFAVNFGDVSIPPNLDFPRPQKISALRGVHGVSSDNIVIVDAQTLLVPNFSYDGEAPDAKFWVGRGQRPTSDGLRIPDENGKENPLRRYERKTIVLTLPEDLTIFDIGHFGVWCEAFTVDFGHVRLPEGLNVPPSLKMLGISPQSKLNCEVLYDDLAFEVRWAVAGESIVVQLVAKLEPNHYMSFGISPNKNISQMIGADAVVAWVDPQTGNGFATDYFLEGKAQCSGGRGACPDTKISEKTNSIRLLNAAMVNGYSIVTYQRSLAATDRLDLPISITGAESVVWAIGPLNDYQEVSFHTFYNKHLHQIEFGRQPKWNCPLPEGARGNSNSSEQEDSAPAAQSSTGGAGYPPAGRPNVEPDEEFYENRAEALHRQPPQRRQETAIITQRRPVPTPKPVNSNGAWDIPAIQCHEPEDGVFYAQMGPTGGKHGYPAITGHVGWGISWYINGLLIPEIHVVRGKTYTFVVEGGNNPDIPAKYHPFYISDDPVGGYEHKREEEKKAVRIYAGVHRSRSGQVTPTGVGRLCNWTPDVEGPPADDYQSFGAYQRTLTLKCDAGEPGVITWKPDRNTPDTVYYHCFTHRYLGWKIHVHDSCDSEAGGLKGAASERHEIRLPAKATVAEPAPVHEDYAGEASVRHETKMASALLRLSRRAY
Protein: Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1) (P09758)
Organism: Homo sapiens (Human)
Function: May function as a growth factor receptor.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Claudin-7
- Claudin-1
- Insulin-like growth factor 1
- Receptor tyrosine-protein kinase erbB-2
- Zinc finger protein 92
- Thyroglobulin
Sequence:
MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPSL
Protein: histidine kinase (EC 2.7.13.3) (Q9HZ34)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Probable two-component response regulator
- LTXXQ domain protein
- Transcriptional activator protein PfeR
- Two-component response regulator
- Transcriptional regulatory protein AruR
- Probable two-component response regulator
- Probable two-component response regulator
- Probable two-component response regulator
- DNA-binding dual transcriptional regulator OmpR
- Response regulator protein CarR
Sequence:
MRSLFWRILAAFWLALLLVAGLSILLGRALNQDTWIIARHPGLKDLAEQWTALYEEQGSYAAQGLLEQRRRDYGISIQVLDESGQRLVDGTYLPRPHHRPPRTSDRNLPRFPWRQLSQEYVSPQSNHTYLFIYRIPHPELEAWHRGSLLWPLSALGIALVVLTLFSLLLTLSITRPLNRLRRAVHDLGQTAYQKDSLARLARRGDELGTLARDFNRMGERLQSLIGSQRQLLRDVSHELRSPLARLRIALALAERAEPEARAQMWPRLEQECDRLEALIGEILALARLDAEPGASQRIALLPLLQRLREDALLLAPEQDIRLEVAPDLSIDGWPDMFERAVDNLLRNAVRFNPVGQPLEVRASSAGDYLRLSVRDHGPGIAAELQEQLGEPFFRAPNQSSPGHGLGLAIARRAIERHGGHLRLGNHPDGGFIATLSLPLRRKATE
Protein: Csad protein (Cysteine sulfinic acid decarboxylase) (Q5U3I6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDESDGKLFLTEAFNIIMEEILNKGRDLKEKVCEWKDPDQLRSLLDLELRDHGECHEKLLQRVRDVAKYSVKTCHPRFFNQLFAGVDYHALTGRLITETLNTSQYTYEVAPVFVLMEEEVISKLRSLVGWSEGDGIFCPGGSMSNMYAINVARYWAFPQVKTKGLWAAPRMAIFTSQQSHYSVKKGAAFLGIGTENVFIVQVDESGSMIPEDLEAKIVQAKSQDAVPFFVNATAGTTVQGAFDPLKRIADICERNGMWMHVDAAWGGSVLFSKKHRHLVAGIERANSVTWNPHKMLLTGLQCSVILFRDTTNLLMHCHSAKATYLFQQDKFYDTSLDTGDKSIQCGRKVDCLKLWLMWKAIGASGLSQRVDKAFALTRYLVEEMEKRENFQLVCKGPFVNVCFWFIPPSLKGKENSPDYQERLSKVAPVIKERMMKRGTMMVGYQPMDEHVNFFRMVVVSPQLTTKDMDFFLDEMEKLGKDL
Protein: Zinc finger protein 273 (Zinc finger protein HZF9) (Q14593)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription intermediary factor 1-beta
Sequence:
MSSAPRGPPSVAPLPAGIGRSTAKTPGLPGSLEMGPLTFRDVAIEFSLEEWQCLDTSQQNLYRNVMLDNYRNLVFLGIAVSKPDLITCLEQGKEPCNMKRHAMVAKPPVVCSHFAQDLWPKQGLKDSFQKVILRRYGKYGHENLQLRKGCKSADEHKVHKRGYNGLNQCLTTTQSKIFQCDKYVKVLHKFSNSNIHKKRQTGKKPFKCKECGKSCCILSQLTQHKKTATRVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEECGKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVFSVLTKHKIIHTGTKPYNCEECGKGFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYTKEKPYKCEECGKAFSVFSTLTKHKIIHTGAKPYKCEECGSAFRAFSTLTEHKRVHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNRSSNLTRHKKIHTGEKPYKPKRCDSAFDNTPNFSRHKRNHMGEKS
Protein: Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (Protein EHM2) (Q9JMC8)
Organism: Mus musculus (Mouse)
Function: Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (By similarity). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H329}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9H329}. Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. {ECO:0000250|UniProtKB:Q9H329}.
Interaction partners:
- Protein kinase C zeta type
- Protein kinase C iota type
- Rho guanine nucleotide exchange factor 18
Sequence:
MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSVLPAAPGGSVFPAGGGPLLTGGAAVHISASGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVTHWLDHAKPIKKQMKVGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSARSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKANPEVHNYQPQYHPDVHPSQPRWRPHSPNVSNHSICKQNKPCFQDDRPHWKTSASGDGSHFDYVQDQNQRNLGGAYSVTYRDKLMTAL
Protein: Ras-related protein Rab-9B (EC 3.6.5.2) (Q8BHH2)
Organism: Mus musculus (Mouse)
Function: Involved in the transport of proteins between the endosomes and the trans Golgi network.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250}.
Interaction partners:
- GRIP and coiled-coil domain-containing protein 2
- Ras-related protein Rab-9A
- Pleckstrin homology domain-containing family M member 2
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Rab GDP dissociation inhibitor alpha
- DENN domain-containing protein 2B
- Rab GDP dissociation inhibitor beta
Sequence:
MSGKSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQKEFIYYADVKDPDHFPFVVLGNKVDKEDRQVTTEEAQAWCMENGNYPYLETSAKDDTNVTVAFEEAVRQVLAVEEQLEHCMLGHTIDLNSGSKASSSCC