wanglab/gogpt-training-data huggingface dataset:
Protein: Transmembrane 4 L6 family member 4 (Q9EQL5)
Organism: Rattus norvegicus (Rat)
Function: Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (By similarity).
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MCTGGCARCLGGTLIPLAVFAVLANILLFFPGGKVVDDNSHLSDEVWYFGGILGSGVLMIFPALVFLGLQNNDCCGCCGNESCGKRFAMFTSTLFAVVGFLGAAYSFIVSAVSINKGPKCFMTNNTWGYPFHDGDYLNDQALWSKCEEPRDVVPWNLTLFSILLVIGGIQMVLCAIQVINGLLGTLCGDCQCCGCCGGDRPV
Protein: Ras-like protein 1 (EC 3.6.5.2) (Ras homolog type B) (P0CY32)
Organism: Candida albicans (Yeast)
Function: Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
Sequence:
MLREYKLVVVGGGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKQCTIDDQQVLLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSINSLNSFQELNSFYDQILRVKDSDNVPVLVVGNKCDLEMERQVSYEDGLALANSFNCPFLETSAKQRINVEEAFYGLVRNINQYNAKIAEAEKQQQQQQQQQNANQQGQDQYGQQKDNQQSQFNNQINNNNNTSAVNGGVSSDGIIDQNGNGGVSSGQANLPNQSQSQSQRQQQQQQQEPQQQSENQFSGQKQSSSKSKNGCCVIV
Protein: Uncharacterized protein (Q38FD1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASEAALSLPADDEKVQADAATNHGTTTPPSSVETAPSTATGAVAPTGSSERESNVVMPAVAVVPALEASECQVQTEPGGNDPITSGELSLVNDHTAPQKLNADVKLFSGDNRPSKSLAAPFRGPSNRPQGIPPGGGTPLWPPNAPLGQTVMSLPHPPMPPHQLYQPPLMIPTLVPNMHPLMAPFISGMAHAPQPPPPPPPPPGFGPPPGSFGPLPFPAALNGPLGAPPPPLMMPNPPDLAVFQPRFPGDKMAASQSSQGPALSKQKSHVLSASSPSAKIIVGNASLAAHVSNDPPKFSCVLLSGISAVGKTTMGRELVNELQADGLGWVFFSGADFISAPTTRRAVWETTKEVFDALEKQLERLLDQQKEKRDLKGLVIDKNVKNVEDIFYLAALLRSKQIPFVGIVGMEADDDEVLLQRMGGERELHEKLKYHRVIHYRIRNLARKAAMYREIDANKPRQEVLNALRTKVLGCCAQPPQNGILSDLYVKSASISMVDDYAEYYTVVTQLFDLIKPLNGSAHFPGTTNYVPLSTRDMADKNRVSAIKESYGARRFNKGTRYLLMYDKGKLYLISTHLRAVLRLSPKALLGDKMASVTCAVFEGDLVRIREDPQTEIFLVFDVLFWNNAADPEGNEVTQMSMEQRHALLSAHLCSESSAFSPTGTDCVVAYRATVKLEEIPKLLEPCGFPGEGIIFQPTSSVHNLNKVYLWRPASSISVDFRIGALRGTREESAVSESGELCADAGSPTLNDSANPGATAGQSQSQLSNSSNPAGQSAVGSGGSSHVRCNEGGPTRTFELEVYDKQEKEYTQFEDCTVDVRHPDVVEGCICTCALADEKGRKWSFQNICYDAVRPAYKRDVSSLLEHSIIPKSKLLQWLASEKITPPLPSGTVPQAATSSAPQQQFWEAVSNSIRQPPPHAPPAYASAVLMQHAMPRPNPSGAHGGGTNLAALAEVVAPTEISKGHQPVLTSTSSAGVGSPPRGLSIGQPPSYKMHGLLQQGLSTSPGTKKVVGVAPDNTVAAVGGSSAAGGSATNTYVVQLLTSMVRSVRTVRKDGVGDECQSTAGATRQEQHPSCVDRSDGDQHRRGHTRFDDVKDRRERGHGKMRRATSGTPGRCMGCGKDKPAEELRFRPKDNLYCYDCWAAKGWETCRECGEFSRGYHERTRECVGEFYCNNCWEKFKEGDNQKKEGRKEDTENQQGERRRRRPKRQIQTVEVKDEGESKTASDFTAEAAGRDGAAKRRARRGQKNDTKDRAAVDIHVGCEEVSEGRTAANDTNAAEQAQEDGTKSNKRHGVESRSNKRHRRKEAVRGE
Protein: Aminopeptidase (EC 3.4.11.-) (B0BCZ6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEIPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
Protein: Protein EARLY FLOWERING 4 (Protein ARRHYTHMIC 44) (O04211)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. Increases ELF3 nuclear distribution and localization in nuclear bodies. Required for responsiveness to continuous red, by regulating phytochrome B (phyB) signaling (including during seedling de-etiolation) and gene expression. Mediates both entrainment to an environmental cycle and circadian rhythm sustainability under constant conditions. Controls flowering time. Necessary for light-induced expression of both CCA1 and LHY.
Subcellular location: Nucleus {ECO:0000269|PubMed:14605220, ECO:0000269|PubMed:22327739}. Note=Diffuse distribution. Targeted to nuclear bodies after interaction with ELF3 (PubMed:22327739). {ECO:0000269|PubMed:22327739}.
Interaction partners:
- Transcription factor LUX
- Protein EARLY FLOWERING 3
- Two-component response regulator-like APRR1
- Protein CCA1
- Protein LHY
- Two-component response regulator-like APRR9
- Two-component response regulator-like APRR7
- Protein GIGANTEA
- Two-component response regulator-like APRR5
- Adagio protein 1
Sequence:
MKRNGETKRRRNVAEEAEQGEDPAMWENLDRNFRQVQSVLDRNRSLIQQVNDNHQSRMADNMSKNVALIQELNGNISKVVNMYSDLNTSFSSGFHGGKNGHDGGGAAGTRA
Protein: TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription initiation factor SL1/TIF-IB subunit A) (P97357)
Organism: Mus musculus (Mouse)
Function: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q15573}.
Interaction partners:
- TATA box-binding protein-associated factor RNA polymerase I subunit D
- TATA box-binding protein-associated factor RNA polymerase I subunit B
- TATA box-binding protein-associated factor RNA polymerase I subunit C
- TATA-box-binding protein
- DNA-directed RNA polymerase I subunit RPA49
- Nucleolar transcription factor 1
- RNA polymerase I-specific transcription initiation factor RRN3
- DNA-directed RNA polymerase I subunit RPA34
- DNA-directed RNA polymerase I subunit RPA1
- General transcription factor IIH subunit 4
Sequence:
MMSDFGEELTKLAVAEDNPETSVLSKTGMHFPWLHKHVEAVVTGGKKRKDFAQTTSACLSFIQEALLKHQWQQAAEYMHSYLQTLEDSDTDKRQAAPEIIWKLGSEILFYHPKSNVETFNSFADRMKNIGVLNYLKISLQHALYLLHHGMLDDANRNLSKAETWRYGEKSSSQEVLINLVQAYKGLLQYYTWTRKKMELSKLDEDDYAYAAKTRTMLSQSCKTSTNICALVKTPGVWDPFVKSYVEMLEFYGDQDGAREMLTNYAYDEKFPSNPNAHVYLYEFLKREKAPRAKLISVLKILHEIVPSHTLMLEFHTLLRKSDTEEHQKLGLSVLFEVLDFAGCNKNITAWKYLAKYLKQILVGSHHEWVEEEWKSRRNWWPAFHFSFFWAKSDWKADTDLACEKAFVAGVLLGKGCKYFRYILKQDHETLKKKIKRMKKSVKKYTIVNPGVHT
Protein: tRNA:m(4)X modification enzyme TRM13 (EC 2.1.1.225) (tRNA methylase 13) (OsTRM13) (Q10B19)
Organism: Oryza sativa subsp. japonica (Rice)
Function: tRNA methylase that catalyzes 2'-O-methyladenosine (Am) nucleoside formation on tRNA(Gly)(GCC) in vitro. May 2'-O-methylate cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). Involved in salt stress tolerance.
Subcellular location: Nucleus {ECO:0000269|PubMed:28369540}. Cytoplasm {ECO:0000305|PubMed:28369540}.
Interaction partners:
- tRNA
- 4-coumarate--CoA ligase
- DEAD-box ATP-dependent RNA helicase 18
Sequence:
MGRAPAKRKPSSPPPPPPPGRCHFWLPNKRRHCANTPLPTSQYCGNHLPDSASDAGAPFRRLVPCPVDPSHTVLEENLEAHVGKCPLKKQAAALAAQPFYSKGINSGGGEGGGGVTSAAKRALVHKLTKDELRALIEKIKLAHASAAMAMRDSFLVTDACDNWMRNQVDRKVPYQEKHVTQQASIIGNMEAFGLLQKGGEVAEENGVKNAPAVVEFGAGRGYLTQMLADCYGIRNVFLVERRSYKLKLKI
Protein: Uncharacterized protein, isoform K (M9PDE6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- TweedleK
Sequence:
MVTICSLSAALSCNIAYRFPIYEMEHLDLAGYLGHTPQSWNTLGTFQDQDAVYLSSSRQMLEPILEETSEDEERARSSLIVSLDRRSTLWSSTESETGSVLRIETIKADIDAVSERDFVCPPKRPRRSHDLNSGQISEDCVQLRRPMPYDPEYHNSFERFLALEACARDSFGSQGQRSSIGSRRGGTFEDFYSDRDSSHSLSRSSSLVQFESLERQLTLQEQHQSMNSLGNSSPSLTCESGASTRARTRDSSPESRKGSAPTLSLLKRYESSDCSHLHQTYYELNNLNFEYKQQQELLSRSLREAELKSDLESSSSSSSSSDSSGHSLLSSCLVPGDAVATERGKQDGTNSRRIPPNSAENLSEDSGYCEPRTLKREKSKSIPKNFEKLCEEEEELLLLEEGAPHSRDFKDEHDLCQTEIEQTADTAALACSPSSINSSPERASSESESASPLPSPTGSASTSSAASFTWLHNSLPDIREPRGPLSVEINNSKPKTNGSVLATTRQNSGSTRSSSSADSCDGISLLGPTHSLNELQVLERRRRPRHIRPSQRNCHSNSSSEELEELDNLFVACHTPPRIRRSCSWNERARKVVGVASAGYLNASYQNLTLLNYTDNWLPAEILQKNHKRSPAEEMSKQSSNTCGNYEHMICKGNFLLDEISKVYDKNVSILTDKPVLDTKLPAPVECDLNEPIECSKVQHVQLNIKPPPRQKRLTQQPPAAMTFNGLVKTFDQDPTNLRTSYTQSLEQCHLDEQETAKPASYPPSAISQRFLPKRRFQSQTSAAKQRSLVSSTPNLAASDDGQPESEYDIYVSSAHASMHQLPQTTTLPKPLGILLPAGSRHSFGKEVSFCPVVSKYCWQEQSSEEPTEDQFHSSEGEQGPPSDDELMDPTLVHNTRENENIAALFEPEPEQAHRLREPAIAQKFTGFHTNALLSASTHAEKNLSCEESANVKNKANLATPDCRDQRTEAKTTLEPEPALSSTVSLKPCAVANSSCREETPSDAINEPASATARPLSLPILSEPPTNRAHRILYSSQQLRRYEPKASPINKMPPANELSPQAAAVARTDEKHPTSRSLFSRFTHGLRFSLRRKKKQQQQEPSQVKESPKELRQSPEESQPVDFVHIPLKPPRSSQCGRLDDTIVSETSSGHVHSWQQQEQLGKTSTLQKVTGKPPLPKMPPRSGILTHAPQETTGETVNCHRTEALPSVEREHCNQLTGQLVAKVQAQRMRDTGLSSQIVVAEETHTVNRLAGHGDATRPTVVTAVPVSVAPVAEVDKMGLIETNLDTHETVISGKTRSLMDITCNPLSMPHKRYIVKRLNVNSVAYDVDELDAEVKPSPGGMASVRRPHKSMEFLLDKENQKNILPPENELQKSHDHNPGALSEHQLRVQASLQRLNIPDWFRHYNKGPEKAADGENACTSATGGGYRPGNFTRKRAQESGRWQGLNSKTTSLSSLGSQRSDRSPLLMSPSAHSHHGGQSSYSCGSTTIHGPAPVQIGMGATRWSTSHLNSTQMSPGASQRGSFTRGAPINSSFISVASGSGLLRNSYRQPYLGWRSTEKLSQRTPHERLANSLLTQRTAPPSTRAGNETRTLHSVSTEIQSSIKEVTSAIVHFVNDQQQSQHPRSRSTSPNSRCWLESSFVGTRTLDSPQTPVIDNSPPELARKQQQLHPHQVHLDVGLSPVVSAGQLPHRMNGINRIGNGGVPTRNIAPERSLSSASLEDVLASLLGLPTTLLSGQNSNSYSSYTPNAATTACAASRQQLEVQSAAELQRLRRRSEGDAPTQEKHYSKEQSHKSNSHSVEAVDSAQPNNPKESRRASLGDPALAATRSDIGSGQLQLIEGPTTGFGSGQHVRCRNTKCDQSTSPSDAKKLYKSCHNCSHLYCSRECRRAHWEKHRKACLHSRASNICRQVLATCKDDIDSQRHLSLLARKGSLSQGRGVVRVLFRSAEAAEGFIKNGFQCMGEASYVRWPDLMPAEMGLELYSELLKLSTEYKPETKMLIYVAICVVSEAPGMGQAPVRWERQLVSRCAKLKLCKTVLAELEQHQAALLQPVSVVAVPERTEILILTFNPGQHSNRELILSNILDILSRRGVMLSKHYPEVFERLQTYSEGQSDKFNPVTLHPRDTQTGQNFVCIIMAVHTDNELTKLPSAADGGNRVTTIDVGSTSALVQLELGDDQICKTKSRES
Protein: Uncharacterized ACR (Q8NSE2)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- SAV-6107-like HEPN domain-containing protein
- Hypothetical membrane protein
- GTPases
- ABC-type transporter, periplasmic component
- DUF2188 domain-containing protein
- ABC-type transporter, permease components
Sequence:
MRGDVQKITKVYDGKHRTLEIPVYQRNYDWTEKQCSRLFDDLSEVVKENHRQHFFGAVVGKPQGSWTWVVIDGQQRLTTISLFMLALVHSLRASEVEEGEFNAGYNIDLATLIEDDYLRSGNEGNLKFKLKPVKNDNEAYQKLFGPESEFIESSNLTANYRYFRNVLKATDLTAAQLWEAIEKLRVMYLDLEEFDDPQRIFESLNSTGLELSEADKVRNLVLMDQELKTQEKLYEQRWNPIEVCVKFDTDNFIRWYLTLKTARTPRKQDVYEEFKKFIRNSKLPVEFILDDMYEYAKLYRDLLGATTGFIAADRCLKRFVPVMGDVVLPFLLPVLKDAKDGIITESDFLGVLKVLESYLFRRFAVGVASNALSKIFSTAYSDIKKFWTPGQSYSSLLAYILKRRDGSGRFPSDSEFRENFATKNFWNIHNENRRYLFDCLENADSNDVRDIQTSLDEGSLSIEHIMPRSLNDQWRAELGPEYARIHETWINRIGNLTITGYNSAYSNSSYERKRTMENGFLVSPYRINNFIKKQKHWSEEQLIERTELLTQAALDYWPLPKETFQPPQAVLPTESLDSDLSFRGREIVAFEYEDYKETVTSWADMLQSVLKVLNQSFRQELIALTNEEICLATSNNSNSSLREIDHGLFVDTGSSTSVKIGFLRRVFTQLGLEQEALVFTLRPLANDVEPRDDELEVEVEKKYSDLTKFIPQLEEAENLEGADTEVIPLLSKLKEQLTAFSPENPQAALGGLPVPEFLKQNVIEQLSAEHILAVLTQHFNIASMMGDDYLLEELRSGRLRELLQRLEELDS
Protein: Polypyrimidine tract-binding protein homolog 2 (Q9FGL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in pre-mRNA splicing. Binds to the polypyrimidine tract of introns. May promote the binding of U2 snRNP to pre-mRNA (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- AT3g17120/K14A17_24
- At3g06330
- At4g21720
- Small nuclear ribonucleoprotein SmD3a
- DEAD-box ATP-dependent RNA helicase 11
- Serine/arginine-rich splicing factor RS41
- Splicing factor U2af large subunit A
- Large ribosomal subunit protein eL18z
- Serine/arginine-rich splicing factor SR30
- starch synthase
Sequence:
MSSVSSQPQFRYTQPPSKVLHLRNLPWECTEEELIELGKPFGTVVNTKCNVGANRNQAFIEFEDLNQAIQMISYYASSSEPAQVRGKTVYLQYSNRQEIVNNKTTADVVGNVLLVTIEGDDARMVSIDVLHLVFSAFGFVHKITTFEKTAGYQALVQFTDAETATAAKLALDGRSIPRYLLAETVGQCSLKITYSAHTDLTVKFQSHRSRDYTNPYLPVAPSAIDSTGQVAVGVDGKKMEPESNVLLASIENMQYAVTLDVLHMVFAAFGEVQKIAMFDKNGGVQALIQYSDVQTAVVAKEALEGHCIYDGGFCKLHITYSRHTDLSIKVNNDRSRDYTMPNPPVPMPQQPVQNPYAGNPQQYHAAGGSHHQQQQQPQGGWVQPGGQGSMGMGGGGHNHYMAPPSSSSMHQGPGGHMPPQHYGGPGPMH
Protein: Growth hormone (Q2V0C8)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MSLSGLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: Transducin-like enhancer protein 3 (ESG) (Grg-3) (Q08122)
Organism: Mus musculus (Mouse)
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). May play an important role during spermatogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q04726}.
Interaction partners:
- Homeobox protein Nkx-2.2
- Hepatocyte nuclear factor 3-alpha
- Histone deacetylase 1
- DNA
- Transducin-like enhancer protein 1
- Nuclear receptor-interacting protein 1
- Lymphoid enhancer-binding factor 1
- Histone acetyltransferase p300
- Transcription factor 7-like 2
- Catenin beta-1
Sequence:
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPITLTSSYPAPFAMMSHHEMNGSLTSPSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
Protein: ARM repeat superfamily protein (Q94K48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Eukaryotic translation initiation factor 5A-2
- Eukaryotic translation initiation factor 5A-3
- Eukaryotic translation initiation factor 5A-1
- Elongation factor P
- Deoxyhypusine synthase
- Elongation factor P
Sequence:
MFLSQFRSCKPLLESRLPLLRLSLSKCLDQSFKTTASSEYGSKINKVTKHVNEEDGATFYVTRRGAIDSSAPAESKAYPKAANISSIHSMRESLLEETEEDYYRRLALFALRNHGGEDAINVIIESLGVESSMIRIEAAFVLGQLESKTAIASLSKILRDVKEHPMVRVEAAKALGFIADEKSREVLQELSGDLDPIIAKGCDSSLSILEFKNSKKYDPLI
Protein: Probable dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Probable dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (O94681)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- 2-oxoglutarate dehydrogenase, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Aconitate hydratase, mitochondrial
- Fumarate hydratase, mitochondrial
- Probable citrate synthase, mitochondrial
- Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial
- Probable isocitrate dehydrogenase, mitochondrial
Sequence:
MTSYGNGFRMMAKCLLSLRSGYSVTAPVSKSMANVLWARYASTRIKTPPFPESITEGTLAQWLKQPGEYVNKDEEIASVETDKIDAPVTAPDAGVLKEQLVKEGDTITIDQDIAVIDTSAAPPEGGSAGPKKDEVKTADADAAKDLSTPQDSSKPIEEKPMPDLGAEQKESAPSSTKPAPDAKEPEFSSPKPKPAKSEPVKQSKPKATETARPSSFSRNEDRVKMNRMRLRIAERLKESQNRAASLTTFNECDMSAVVALRKKYKDEILKETGVKIGFMSFFSKACTQAMKQIPAINGSIEGEGKGDTLVYRDFCDLSIAVATPKGLVTPVIRNAESMSLLEIESAIATLGSKARAGKLAIEDMASGTFTISNGGIFGSLYGTPIINLPQTAVLGLHAIKERPVVINGQVVPRPMMYLALTYDHRMVDGREAVTFLRLVKEYIEDPAKMLLV
Protein: Candida glabrata strain CBS138 chromosome D complete sequence (Q6FVW0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome K complete sequence
Sequence:
MGEQVEDMDKLYETPIDMQTTIFDQVDNYLHMVNSGLQHDEKEDEHREHEDAIDGGASLNMHLYNINDTLNGVSTDNGHFDMVDLHFGPTLTTDDDPTKMAELQHTTIHHGHLDVNGNRSDSLFSPFDSPLVHDTPSLEARNSIQLTNEGSTSALTTPFLSGKNHYDDHGNSINSQSFNYHNRNSSLSKVSGKFSPISSPALTSTNQEQQHWNTSSRRASNSSSRSKRVLPSGNSSVSSTSNKVIKNSPYMNASSRRLQKTISNGNSKRDEWDEFMFSLPESSLANDLTTGNDENMDISLPAGHSPTKEYNSYPKVILPSHAAENESMETDNYERASLLEDSQPDETQNNNPQNNNPHSNGSSISPVGKNDSVMLASGSPVLKPQNSSSNILQTPYSSKRVFKSPADISSTEQTADEASNDASNDAKSKDKKQRKPSSSGPNKLKRTNTGGSIGRVRSDSASQNSDYVQRKKEVHKYAEQERRNRLNNALSDLNSLLPQDWKDAVTVPSKAITAELACKYIRTLLEELEQYKK
Protein: YTH domain-containing family protein 3 (DF3) (Q7Z739)
Organism: Homo sapiens (Human)
Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:32492408, ECO:0000305|PubMed:28106072}. Cytoplasm, P-body {ECO:0000269|PubMed:32492408}. Cytoplasm, Stress granule {ECO:0000269|PubMed:32451507}.
Interaction partners:
- Eukaryotic translation initiation factor 4 gamma 2
- N
- YTH domain-containing family protein 2
- YTH domain-containing family protein 1
- Protein virilizer homolog
- N
- Pre-mRNA-splicing regulator WTAP
- RNA demethylase ALKBH5
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Heterogeneous nuclear ribonucleoproteins C1/C2
Sequence:
MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ
Protein: IP17195p (P130CAS, isoform D) (A4IJ58)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Adapter molecule Crk
- Paxillin, isoform F
- Vinculin
- Focal adhesion kinase, isoform D
- Rhea, isoform B
- Tyrosine-protein kinase
- Guanine nucleotide-releasing factor 2
- Myoblast city, isoform B
- Zyx102 protein
- Integrin beta-PS
Sequence:
MECQSENRVPENSISNVATYHTLPESQTSSVLAKHQQRQLKEPQQPPQYVINSVAMHAKTTTANSITGGTLHRAKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLNSYDSGCFSPSPASSPVPSLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGASSGLGSESVSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIYSNQSIYQNFAMMSSPRQNASGSEFETYDIPKPATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRFETLKSVAASIAEESYDVPRPLILGSNQLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQLTVGHNGGSGTGVLEGSRGSAEWLEDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESSAMGAGSGSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDLKSVMLQAVHLSTAAGVGA
Protein: DnaJ homolog subfamily C member 14 (J domain protein interacting with viral protein) (Jiv) (Q95J56)
Organism: Bos taurus (Bovine)
Function: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity). Promotes cleavage of pestivirus polyprotein.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11533209}; Multi-pass membrane protein {ECO:0000269|PubMed:11533209}.
Interaction partners:
- Spermatosis associated serine rich 1
Sequence:
MAQKHPGEGGLCGAHHSGGASLRTLGPSVDPDILSFSGLRDSAGSAPNGTRCLTEHSSPKYTQPPNPAHWSDPSHGPPRGPGPPLAEEDPDQSEASSEESGVDQELSRENETGYQDDGNSSFLSIPSTCNCQGTPGIPEGPYSEGRDSSSSNFCHHCTSPALGEDEELEGEYDEEEPLKFPSDVSRVPSEKKPAPRRQRHRVPAKEDTREGGRRDPRSPGRHRLGRKRSQADKRRGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKGSDLDLLRVWVGVWAGRLRGWAQVMFQFLSQGFCYGAGLFTRFLRLVGALLLLALALLLGCLQLGWRFLVGLSDRLGWRDKATWIFSWLASPTWQRCLILLRESRPWQQLVRIVQWGWLELPWVKQRTNRQANAPVAGGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRMPGTSGRQRATPDAPPADLQDFLSRIFQVPPGQMSNGNFFAAPQPGPGATAASKPNSTVPKGEAKPKRRKKVRRPFQR
Protein: Steroid isomerase, putative (P71817)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTQTTQSPALIASQSSWRCVQAHDREGWLALMADDVVIEDPIGKSVTNPDGSGIKGKEAVGAFFDTHIAANRLTVTCEETFPSSSPDEIAHILVLHSEFDGGFTSEVRGVFTYRVNKAGLITNMRGYWNLDMMTFGNQE