wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleoporin nup146 (Nuclear pore protein nup146) (Q09847)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular location: Cytoplasm. Nucleus. Note=Nuclear rim.
Interaction partners:
- Nucleoporin nsp1
- Nucleoporin nup107
- Nucleoporin nup189
- ATP-dependent RNA helicase dbp5
- mRNA export factor gle1
- Exportin-1
- Nucleoporin nup85
- Nucleoporin nup44
- Nucleoporin seh1
- Probable nucleoporin C890.06
Sequence:
MNAENTFSILNTNEPNAGGSQVTESEIEEEDIEFLSFAALKIGATSSLSNSSLGLPEYSNLFAINNLKSLFVAGVPNYLIIGSTLDLQKSLIDADENVDANVLKDSASIRHVSLPDAKFSMVSFSSNGEFVIAYDFVSFELSVYETDALLKNSATSIYKAVFPDLVQVLPNPEINNLVILRNLKLEVFLLSLSKFQVESPLAKDATCAAWSRRGKQCVIGFNNGTMSQYTPAGEIKLRIPRPPSLENYFVECISWIENREFVVFYSPLTSLSNESDEPPHESECFVISVGMNGHFNFGKAGDPTPPFGAVNRRDHHYIASLHAWKPDLRSLVVVANTASADLGVLALSMEKNQWSILNIVDETKRASLPYSNKKDSDSSPTALVMDFTATDRISKPLDPTEAPADCSPLPIVWVFNDEFQLVAYRIFYADAISKSIDYPEMNVIKDKNKDSTVRASNNENIPTPDKQASPFVKNLSSTSSPFSQSSAFGNFKFGQATSFDKGLSTDASSGAKSNTPVFGQPSTFGQAPVFGQPSAFGQAPVFGQPSAFGQSSFSFGTSNMNQKLDFGTFKSPLSGAATGEAKTNLEKAVTSASGKASFTGFAPSQSTTSGLNFDSIPKDNEAASIFGSSQVSTKNTSGFQFSNNTLLADNVDEDIESDHDTKIEELANSDVEPSTEQNIGGDVSWGASTFQSKPQPSFSFGLTLDDKSNTPGKNFSIFGKTAETQVEQKKPENNVLTKPFSFAPSDKSMFAANIPSAGEGLDQQKTSKALPSTGITKLSENDNEKAEESNETKGFNTTIAKQNDKSSKSEGKASVANMSALNKSTNNETSDSKPSLKSPLFNFSADAPTFTFNKPSETPPFSFNKPLVEKESKQDVSDTSDRSPFSFKAFGIDSKKSPTPEPTEMAESNISEESEGWKLIEQPNVESEIEDQDEESSDLNGKRRSTPPKIHEVGVNKMLDVVPKEKRDLNSFFPKQPLVVQSTDKNKKEPQESLEDEILSAEGFSEVEAANKISRFEPFSSPKLKLATSDNAPEKYVFEESESSDLEEGPVPLRNLESLADLPEAESNEKLPMVNTFERLYLQFKNELDLVWQNINIIAEYIEGQTSTPSAVSEQATMAMLSQNTEELEDLLDTVTSFSAFCSDYSKQIDYLEACLVRINAKRIQVTRLLKALTNPAFEKQMELRQLGPEALRRQKELRLKMEKVLKSLSTLEQQAVDARMSDTRRFKKPTLGSIEVAYSRIATLLGQRLKQLYKLEKDIKRMATKKKMITKKSMSSDMMTQFRALGISQSSTKQVSAHYLREFERQDAFRNGVFKRLTSLKKAD
Protein: DNA replication licensing factor MCM5 (EC 3.6.4.12) (A0A8U0WNY5)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368063}.
Interaction partners:
Sequence:
MEGVLAVSDGHDLYTNDVGSVRGNLEPKIISFVKNFSKHKNNIFDYREQLQRNIRMGKYFLEIDIMDLQNFDESLKEALFKHASEFISIFENVLSVQVLSMRGWEKKEDYIESDTGGPMMQVIIKDTQSKMIQPRMLQSSFLSKVIRVSGIIVSISRVEPKVTKAILRCRSCQKEIAVIVPSCCGIINYPKSCDGVSPVTGKKCPPDPYDVVTEKCKFVDRIVLKLQETPENVAPGEVPRTVTVILERYLVVGLTAGQRICIEGIFGASLQRKGTISTSYIRAIGIEISGQVVSQDDRRMKEVARTITKEKLIKSIAPAICGYDDIKEAVLCLMLGGSGKALPDGTHLRGDINVLLMGDPGTAKSQLLKFVQMATPIGVYTSGKGSSAAGLTAAVNKDSSTGEFYLEGGALVLGDGGVVCIDEFDKMNEVDRVAIHEAMEQQTISIAKAGITAVLNARSAVLAAANPSFGRFNERASFGDNVNLKTTILSRFDMIFMIRDKHDAKRDKEIVKHIMDIHRQDVKVDNLSTDILKEYIAYCKAYCIPRLTENASNKLSNYFVSIRQKVRENKLENDNDEGIPITVRQLEAIIRISEALAKMTMSDIADENHVDEAIRLFELSTMNSAVRQKEKHKKRRDDK
Protein: Probable disease resistance protein At4g19520 (EC 3.2.2.6) (F4JT82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable disease resistance protein.
Interaction partners:
- Ankyrin repeat family protein
- Phosphatidylinositol 3-and 4-kinase family protein
- Nucleic acid-binding, OB-fold-like protein
- Putative cysteine-rich repeat secretory protein 24
- Probable disease resistance protein At5g47260
- Probable disease resistance protein RF45
- Protein disulfide-isomerase 5-4
- Probable disease resistance protein At1g62630
Sequence:
MVDGKEVYISFNRWEDTIRHSFVSHLSAEFQRKGVSVFASEDSASDDRFAEESDAAIAKARVSVVIFSENFASSKGCLNEFLKVSKCRRSKGLVVVPVFYGLTNSIVKKHCLELKKMYPDDKVDEWRNALWDIADLRGGHVSSHKRSDSELVEKIVADVRQKLDRRGRIGVYSRLTKIEYLLCKQPGCIIRSLGIWGMAGIGKTTLARAAYDQLSRDFEASCFIEDFDREFQEKGFFGLLEKQLGVNPQVTRLSILLKTLRSKRILLVLDDVRKPLGATSFLCEFDWLGPGSLIIVTSQDKQVLVQCQVNEIYKVQGLNKHESLQLFSRCAFGKDVPDQNLLELSMKFVDYANGNPLALSICGKNLKGKTPLDMKSVVLELKRHLSDKIFVKLKSSYDALSVSEKEIFLDIVFTFRGANVDNVMQSLAGCGFFPRVGIEALVDKSFVTVSENRVQVNNLIYDVGLKIINDQSDEIGMCYRFVDASNSQSLIEHKEIRESEQGYEDVKAINLDTSNLPFKGHIAFQHMYNLRYLTIYSSINPTKDPDLFLPGDPQFLPPELRLLHWTCYPLHSFPQNFGFQYLVELNMPCSKLKKLWGGTKNLEVLKRITLSCSVQLLNVDELQYSPNIEKIDLKGCLELQSFPDTGQLQHLRIVDLSTCKKIKSFPKVPPSIRKLHLQGTGIRDLSSLNHSSESQRLTRKLENVSSSNQDHRKQVLKLKDSSHLGSLPDIVIFESLEVLDFSGCSELEDIQGFPQNLKRLYLAKTAIKEVPSSLCHHISKLVKLDMENCERLRDLPMGMSNMKYLAVLKLSGCSNLENIKELPRNLKELYLAGTAVKEFPSTLLETLSEVVLLDLENCKKLQGLPTGMSKLEFLVMLKLSGCSKLEIIVDLPLNLIELYLAGTAIRELPPSIGDLALLDTLDLKNCNRLRHLPMEMHNLNPLKVLDLSNCSELEVFTSSLPKVRELRPAPTVMLLRSKLPFCFFIFYEHRVTLSLYKARLQYIPEEIRWMPSLKTLDLSRNGFTEVPVSIKDFSKLLSLRLRYCENLRSLPQLPRSLQLLNAHGCSSLQLITPDFKQLPRYYTFSNCFGLPSHMVSEVLANAPAIVECRKPQQGLENALACSFCLPSPTSRDSKLYLQPGSSTMIILNPKTRSTLVGFAILVEVSFSKDFHDTAGLGFRCVCRWNDKKGHAHKRDNIFHCWAPGEVVPKINDDHMFVFFDLKMHPSILFEGDVFGILADLVVFEIFPVNKQEMHVGDSCTITKCGVYVINDAAGSSSGNTMTPQCSSMDSLKLLDGKGKKRLRVNYAGLKQREKALFLYIACLLGGEKADLLAQFLASTDFVIESTLEDLAGRYLIDISSNGEVMMPPLQRNFSREIIHMLPASTKELVSMASGSPCNRNNDVFVSFHGKDFRKQFISDFLKKLVYKGIRICIGDKILSRSLINKVIKESSIAVVVFSENYASSSLCLLQLMEIMKCWEELGQVVMPIFYKVNPSDIRNQSGHFGKGFKKTCKKTINDERQRWSRALTDAASIAGECSLNWASDADMIEKVANDIRKKLISSKKLGKQIQRVDCDHDNPWETEFNKCIERFFQLPYDGNHDESLVSLTTEKVIDMKQTLKEIYQITKVKLKNNLVGRRHINNICFMHILYEKCEERSSFNPTSLHTLYDNGIPYQVYTKRKKHMSGEEKAPIGGCVGCFYMGQNQGITKAGGGRTMPTAYPAAPQANQGYNAGAQPYPPTAYAV
Protein: Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) (P85091)
Organism: Bos taurus (Bovine)
Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TMB8}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
Interaction partners:
Sequence:
MYLTPSEKRINLSKVHPTDKLADQIFAYYKEGERDGKDEIIKNVPLKRIRK
Protein: Zinc finger protein 286A (Q9HBT8)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
METDLAEMPEKGALSSQDSPHFQEKSTEEGEVAALRLTARSQETVTFKDVAMDFTPEEWGKLDPAQRDVMLENYRNLVSLWLPVSKPESYNLENGKEPLKLERKAPKSSYSDMETRPQSKDSTSVQDFSKAESCKVAIIDRLTRNSVYDSNLEAALECENWLENQQGNQERHLREMFTHMNSLSEETDHKHDVYWKSFNQKSVLITEDRVPKGSYAFHTLEKSLKQKSNLMKKQRTYKEKKPHKCNDCGELFTYHSVLIRHQRVHTGEKPYTCNECGKSFSHRANLTKHQRTHTRILFECSECKKTFTESSSLATHQRIHVGERPYECNECGKGFNRSTHLVQHQLIHTGVKPYECNECDKAFIHSSALIKHQRTHTGEKPYKCQECGKAFSHCSSLTKHQRVHTGEKPYECSECGKTFSQSTHLVQHQRIHTGEKPYECNECGKTFSRSSNFAKHQRIHIGKKPYKCSECGKAFIHSSALIQHQRTHTGEKPFRCNECGKSFKCSSSLIRHQRVHTEEQP
Protein: Outer envelope pore protein 21A, chloroplastic (Chloroplastic outer envelope pore protein of 21 kDa A) (Q6ID99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-dependent rectifying anion channel that facilitates the translocation between chloroplast and cytoplasm of phosphorylated carbohydrates such as triosephosphate, 3-phosphoglycerate and inorganic phosphate (Pi) depending of ATP to triosephosphate ratio in the plastidial intermembrane space; in high triosephosphate/ATP conditions (e.g. photosynthesis), export of triosphosphate from chloroplast (outward rectifying channels), but in high ATP/triosephosphate conditions (e.g. dark phase), import of phosphosolutes (inward rectifying channels) (By similarity).
Subcellular location: Plastid, etioplast membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Plastid, chloroplast outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Present in non-green root plastids. {ECO:0000250}.
Interaction partners:
Sequence:
METSLRYATNSRSLKIHAKEKFPVNSKTRLQLHGELDTGAGVPSYFCAMIRYFFHEASTNLGVGLHYDKREKLRCLVRGKKKFPVITDEVVTFNIKGRCDFDQDLVQRNAKGAAEFDWNIWKFQKDQDLRLRIGYEMFEKVPYMQIRENNWTFNTNLKGKWNVRYDL
Protein: Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32) (Q9Y5X9)
Organism: Homo sapiens (Human)
Function: Exerts both phospholipase and triglyceride lipase activities. More active as a phospholipase than a triglyceride lipase. Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins.
Subcellular location: Secreted {ECO:0000269|PubMed:10318835}.
Interaction partners:
- Gastric triacylglycerol lipase
- Patatin-like phospholipase domain-containing protein 2
- Monoglyceride lipase
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Pancreatic triacylglycerol lipase
- Bile salt-activated lipase
- Hepatic triacylglycerol lipase
- Pancreatic lipase-related protein 3
- Phospholipid phosphatase 5
- Lipoprotein lipase
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
Protein: Upstream transcription factor 1 (F7FDQ5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLRVAVLRQSHTVPTVSFSELRQLLASGRARLFDVRSREEAAAGTIPGALNIPVSELEMALNMDPAAFQTSYCAEKPKLEDKNLIFFCQMGRRGLQATQLAQGLGYTGARNYAGAYKEWLEKEG
Protein: MYB proto-oncogene, transcription factor (A0A087WTI6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAPTGVQWHDFGSLQPLPPGFKRFSCLSLPRSWDYRHPPPRPANFEFLVETGFLHVGQAGLELLTSGDLPASASQSARITGVSHRARPGGIFLQAPF
Protein: Fibroblast growth factor 5 (FGF-5) (Heparin-binding growth factor 5) (HBGF-5) (Smag-82) (P12034)
Organism: Homo sapiens (Human)
Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Pro-epidermal growth factor
- Klotho
- Fibroblast growth factor receptor 3
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Fibroblast growth factor-binding protein 1
- Vascular endothelial growth factor receptor 2
- Epidermal growth factor receptor
Sequence:
MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG
Protein: Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (H0YEM1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATATIALVNGQQGGGSEPAAAAAVVAAGDKWKPPQGTDSIKMENGQSTAAKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLGTLGTPGLVSPALTLAQPLGTLPQAVMAAQAPGVITGVTPARPPIPVTIPSVGVVNPILASPPTLGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQERFDNSDLSA
Protein: Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) (O26708)
Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01571}.
Interaction partners:
- Fused uL13/uS9 ribosomal subunit protein
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL32
Sequence:
MQKPIKKDPNRYHGEKMTEFSEWFHNILEEAEIIDQRYPVKGMHVWMPHGFMIRKNTLKILRRILDRDHEEVLFPLLVPEDELAKEAIHVKGFEDEVYWVTHGGLSKLQRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYETKHTRPLIRVREITTFKEAHTIHATASEAEEQVERAVEIYKEFFNSLGIPYLITRRPPWDKFPGSEYTVAFDTLMPDGKTLQIGTVHNLGQTFARTFEIKFETPEGDHEYVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVPIIFKKAAEEVMEACRELRSRLEAAGFRVHLDDRDIRAGRKYYEWEMRGVPLRVEIGPRDLEKGAAVISRRDTGEKVTADLQGIEETLRELMKDILENLRTRAWERMESEIREAETLEEASRIVDEKRGIISFMWCGEEECGMDVEEKVRVDILGIQEEGSGTCINCGREAPTGLTLPEHIS
Protein: Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 8) (Q9EQH4)
Organism: Mus musculus (Mouse)
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity). TAF8 is involved in forming the TFIID-B module, together with TAF5 (By similarity). Mediates both basal and activator-dependent transcription (By similarity). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.
Subcellular location: Nucleus {ECO:0000269|PubMed:11076765}. Cytoplasm {ECO:0000269|PubMed:11076765}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.
Interaction partners:
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 13
- TATA-box binding protein associated factor 4
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 7
Sequence:
MADTAAGPGGSGTRPGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQILREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEIQQMEETDSSEQEEQTDTENNALHISTDDSGAEKESASVLQQSSSLSGSRNGEESVIDNPYLRPVKKPKIRRKKSLS
Protein: Transcription factor DUO1 (Myb-related protein 125) (AtMYB125) (Protein DUO POLLEN 1) (A0A178VEK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression. Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization. Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon. Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:15694308}. Note=Accumulates in sperm-cell nuclei. {ECO:0000269|PubMed:15694308}.
Interaction partners:
- Homeodomain-like superfamily protein
- Zinc finger protein ZAT2
- Zinc finger protein ZAT3
- Protein GAMETE EXPRESSED 2
- Protein HAPLESS 2
- F-box/LRR-repeat protein 17
- Protein PLANT CADMIUM RESISTANCE 11
- At4g35700
- Protein DMP9
- Transducin/WD40 repeat-like superfamily protein
Sequence:
MRKMEAKKEEIKKGPWKAEEDEVLINHVKRYGPRDWSSIRSKGLLQRTGKSCRLRWVNKLRPNLKNGCKFSADEERTVIELQSEFGNKWARIATYLPGRTDNDVKNFWSSRQKRLARILHNSSDASSSSFNPKSSSSHRLKGKNVKPIRQSSQGFGLVEEEVTVSSSCSQMVPYSSDQVGDEVLRLPDLGVKLEHQPFAFGTDLVLAEYSDSQNDANQQAISPFSPESRELLARLDDPFYYDILGPADSSEPLFALPQPFFEPSPVPRRCRHVSKDEEADVFLDDFPADMFDQVDPIPSP
Protein: Synaptobrevin homolog 2 (P33328)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.
Subcellular location: Endomembrane system; Single-pass type IV membrane protein. Note=Post-Golgi vesicle membrane. {ECO:0000305}.
Interaction partners:
- Protein SSO1
- Integral membrane protein SED5
- Syntaxin PEP12
- Protein transport protein SEC9
- Vacuolar morphogenesis protein 7
- Protein SSO2
- t-SNARE affecting a late Golgi compartment protein 1
- t-SNARE VTI1
- Syntaxin VAM3
- t-SNARE affecting a late Golgi compartment protein 2
Sequence:
MSSSVPYDPYVPPEESNSGANPNSQNKTAALRQEIDDTVGIMRDNINKVAERGERLTSIEDKADNLAISAQGFKRGANRVRKQMWWKDLKMRMCLFLVVIILLVVIIVPIVVHFS
Protein: Low molecular weight protein-tyrosine phosphatase A (LMW-PTP) (PTPase) (EC 3.1.3.48) (Low molecular weight tyrosine phosphatase PtpA) (MPtpA) (P9WIA1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Key virulence factor required for mycobacterial survival within host macrophages. Exhibits protein tyrosine phosphatase activity. Shows no detectable activity towards substrates containing phosphoserine/threonine residues.
Subcellular location: Secreted {ECO:0000269|PubMed:10986245, ECO:0000269|PubMed:12066895, ECO:0000269|PubMed:18474358}. Host cytoplasmic vesicle, host phagosome {ECO:0000269|PubMed:18474358}. Host cytoplasm {ECO:0000269|PubMed:18474358, ECO:0000269|PubMed:28811474}. Host nucleus {ECO:0000269|PubMed:28811474}. Note=Translocates into the host cytosol by crossing the host phagosomal membrane during human macrophage infection. Colocalizes with host VPS33B in macrophage cytosol and associates with phagosomes. {ECO:0000269|PubMed:18474358}.
Interaction partners:
- Triple specificity protein phosphatase PtpB
- Tyrosine-protein kinase PtkA
- Uncharacterized SURF1-like protein Rv2235
- Phosphatidylinositol-3-phosphatase
- Bifunctional protein Rv2228c
- GTP cyclohydrolase 1 type 2 homolog
- Uncharacterized protein Rv2229c
- Histidinol-phosphate aminotransferase Rv2231c
- Nucleoside diphosphate kinase
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
Protein: RNA-binding motif protein, X-linked 2 (Q9Y388)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the activated spliceosome.
Subcellular location: Nucleus {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316}.
Interaction partners:
- BUD13 homolog
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 2
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Smad nuclear-interacting protein 1
- Splicing factor 3B subunit 3
- Splicing factor 3B subunit 4
- Splicing factor 3B subunit 1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
- Serine/arginine repetitive matrix protein 2
Sequence:
MNPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRIRDRGRSSDAHSSWYNGRSEGRSYRSRSRSRDKSHRHKRARRSRERESSNPSDRWRH
Protein: Rhodomycin D methylesterase DnrP (EC 3.1.1.-) (10-carbomethoxy-13-deoxycarminomycin esterase) (4-O-methylrhodomycin D methylesterase) (Q54809)
Organism: Streptomyces peucetius
Function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the removal of methyl group from the carbomethoxy group of rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 4-O-methylrhodomycin D to yield 10-carboxy-13-deoxycarminomycin and 10-carboxy-13-deoxydaunorubicin, respectively. Could be also involved in the decarboxylation of 10-carboxy-13-deoxycarminomycin and 10-carboxy-13-deoxydaunorubicin to yield 13-deoxycarminomycin and 13-deoxydaunorubicin, respectively. It seems that DnrK may influence the ability of DnrP to carry out the decarboxylation (Probable).
Interaction partners:
Sequence:
MPTRMITNDEVTLWSEGLGDPADAPLLLIAGGNLSAKSWPDEFVERLVAAGHFVIRYDHRDTGRSSRCDFALHPYGFDELAADALAVLDGWQVRAAHVVGMSLGNTIGQLLALDAPERLLTLTVMLGGALDVDFDADLEAALKGEPSVSGLPVPSQRFLDMMTMLQQPAETDEELLERRVEKWRLLNGEGVPFDADEFRRRELLAAGHAGTFDEPIVHHMIPLPPVSRGAELSRVTTPVLAIQAMCDPAAPPPHARHLANRIPGARVVEIENMGHALPLAVHEPLAAAICAHTRAATV
Protein: FI14601p (Hand) (Q9VL05)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Muscle-specific homeobox protein tinman
Sequence:
MFKNSVALTCEYSTMYYNSIYNTSNMFDMKHSESQVQQQIYNTSHLGYVPTSNTRIVKKRNTANKKERRRTQSINNAFSYLREKIPNVPTDTKLSKIKTLKLAILYINYLVNVLDGDLDPKGGFRAELKPVSRKICSEKKHCLKSEIQNVPLSTKGRTGWPQDVWASELIPEHN
Protein: Hemoglobin subunit beta-2 (Beta-2-globin) (Hemoglobin beta-2 chain) (P83625)
Organism: Pseudaphritis urvillii (Congolli) (Freshwater flathead)
Function: Involved in oxygen transport from gills to the various peripheral tissues.
Interaction partners:
Sequence:
VEWTDFERATIKDIFSKIEYEVVGPAALARCLVVYPWTQRYFGKFGNLYNAEAITGNPMISKHGTTILHGLDRAVKNMDDIKNTYAELSVLHSETLHVDPDNFKLLSDCLTIVVAGQLGKDFTGEVQAAFQKFLAVVVSSLGRQYH