wanglab/gogpt-training-data huggingface dataset:
Protein: N-acetylaspartate synthetase (NAA synthetase) (EC 2.3.1.17) (Camello-like protein 3) (N-acetyltransferase 8-like protein) (Q8N9F0)
Organism: Homo sapiens (Human)
Function: Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA. Promotes dopamine uptake by regulating TNF-alpha expression (By similarity). Attenuates methamphetamine-induced inhibition of dopamine uptake.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19524112}. Microsome membrane {ECO:0000250|UniProtKB:D3ZVU9}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:19524112}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3UGX3}; Single-pass membrane protein {ECO:0000255}. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. {ECO:0000269|PubMed:19524112}.
Interaction partners:
- Aspartoacylase
- Beta-citrylglutamate synthase B
- N-acetylaspartylglutamate synthase A
- Asparagine synthetase
- Glutamate carboxypeptidase 2
- Putative aspartate aminotransferase, cytoplasmic 2
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Argininosuccinate synthase
- Multifunctional protein CAD
Sequence:
MHCGPPDMVCETKIVAAEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPAPPPAPVAQPHGGAGGAGPPGGRGVCIREFRAAEQEAARRIFYDGIMERIPNTAFRGLRQHPRAQLLYALLAALCFAVSRSLLLTCLVPAALLGLRYYYSRKVIRAYLECALHTDMADIEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYVLPGMTLSLAERLFFQVRYHRYRLQLREE
Protein: 1-aminocyclopropane-1-carboxylate synthase 2 (ACC synthase 2) (EC 4.4.1.14) (S-adenosyl-L-methionine methylthioadenosine-lyase 2) (Q06402)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
Interaction partners:
- Mitogen-activated protein kinase 6
- Mitogen-activated protein kinase 3
- 1-aminocyclopropane-1-carboxylate oxidase 4
- 1-aminocyclopropane-1-carboxylate oxidase 1
- 1-aminocyclopropane-1-carboxylate oxidase 2
- 1-aminocyclopropane-1-carboxylate synthase 6
- 5'-methylthioadenosine nucleosidase
- 1-aminocyclopropane-1-carboxylate synthase-like protein 1
- Mitogen-activated protein kinase 10
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Sequence:
MGLPGKNKGAVLSKIATNNQHGENSEYFDGWKAYDKDPFHLSRNPHGIIQMGLAENQLCLDLIKDWVKENPEASICTLEGIHQFSDIANFQDYHGLKKFRQAIAHFMGKARGGRVTFDPERVVMSGGATGANETIMFCLADPGDVFLIPSPYYAAFDRDLRWRTGVEIIPVPCSSSDNFKLTVDAAEWAYKKAQESNKKVKGLILTNPSNPLGTMLDKDTLTNLVRFVTRKNIHLVVDEIYAATVFAGGDFVSVAEVVNDVDISEVNVDLIHIVYSLSKDMGLPGFRVGIVYSFNDSVVSCARKMSSFGLVSSQTQLMLASMLSDDQFVDNFLMESSRRLGIRHKVFTTGIKKADIACLTSNAGLFAWMDLRHLLRDRNSFESEIELWHIIIDRVKLNVSPGSSFRCTEPGWFRICFANMDDDTLHVALGRIQDFVSKNKNKIVEKASENDQVIQNKSAKKLKWTQTNLRLSFRRLYEDGLSSPGIMSPHSPLLRA
Protein: Golgi-localized, gamma-adaptin ear containing, ARF binding protein (Golgi-localizing gamma-ear-containing ARF-binding protein) (LD41311p) (Q9W329)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Early endosome membrane {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004220}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004150}.
Interaction partners:
- Lysosomal enzyme receptor protein, isoform E
- LD23155p
- Rabaptin-5-associated exchange factor for Rab5
Sequence:
MTTDESIMEEMLERATNPAQKIDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLEECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAYDMLRKEGDIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDVSETLHELYKSCKKHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTASSTTATTSSNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDMLSEELFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVDSIDDVPLLSDDVEKKDEAVVAPVTVVPPAKPLSEINVELDNIQATGEQRIVLDDDDMQLSLNFTSDRPGHRVSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGDDPDPIKESIVAKGIDYVD
Protein: Amine oxidase [copper-containing] zeta, peroxisomal (AtCuAO1) (AtCuAO3) (AtCuAOzeta) (Copper amine oxidase 3) (EC 1.4.3.21) (Q8L866)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in putrescine catabolism in peroxisomes. Copper amine oxidase that can use putrescine and spermidine as substrates.
Subcellular location: Peroxisome {ECO:0000269|PubMed:23915037}.
Interaction partners:
- Polyamine oxidase 1
- Probable polyamine oxidase 5
- Tyrosine decarboxylase 2
- Probable polyamine oxidase 4
- Phenylacetaldehyde synthase
- Polyamine oxidase 3
- Polyamine oxidase 2
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Aspartate aminotransferase, chloroplastic
- Precursor of CEP12
Sequence:
MASASKKTSACPHHGGSLPPPKLVSAAPDTVAVWSDADDQRASKVSLESVIRPVDSFPDNTAKKPANKGISVMPRTETKHPLDPLSAAEISVAVATVRAAGANPEVRDGMRFIEVASVEPDKQVVALADAYFFPPFQPSLLPRTKSGPVIPMKLPPRRARLVVYNQKSNETSVWIVALSEVHAVTRGGHHRGRVVSSQVIPDVQPPMDAAEYAECEAIVKDFPPFIEAMKRRGIEDMDLVMVDPWCVGYHSEADAPSRRLAKPLIYCRTDSDSPMENGYARPVEGIYVLVDMQNMVVIEFEDRKFVPLPPPDPLRNYTPGESRGGVDRSDVKPLQIIQPEGPSFRVRGYFVEWQKWNFRIGFTPREGLVIHSVAYVDGSRGRRPVAHRLSFVEMVVPYGDPNEPHYRKNAFDAGEDGLGKNAHSLKKGCDCLGSIKYFDAHFTNFTGGVETIENCVCLHEEDHGILWKHQDWRTGLAEVRRSRRLTVSFLCTVANYEYGFYWHFYQDGKIEAEVKLTGILSLGALQPGETRKYGTTIAPGLYAPVHQHFFIARMDMSVDCKPAEAFNQVVEVNVRVDERGENNVHNNAFYAEEKLLKSEAVAMRDCDPLSARHWIVRNTRTVNRTGQLTGYKLVPGSNCLPLARPEAKFLRRAAFLKHNLWVTRYAPDEKFPGGEFPNQNPRAGEGLATWVKQNRSLEESDVVLWYVFGITHVPRLEDWPVMPVEHIGFTLMPHGFFNCSPAVDVPPNPCELETKESEVKEVVAPKALQTGLLSKL
Protein: Butyrophilin-like 6 (A2CG22)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Perilipin-2
- Xanthine dehydrogenase/oxidase
- Butyrophilin, subfamily 3, member A3
Sequence:
MENHRKPSLLFHVSCLFVLIQLLSWVTTKEFQVFGPSDPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRFSAAVLVYRDQEEQKREQLPEYSQRTSLVKEQFHQGTAAVRILNVQAPDSGIYICHFKQGVFYEEAILELKVAAMGSVPEVYIKGPEDGGVCVVCITSGWYPEPQVHWKDSRGEKLTASLEIHSEDAQGLFRTETSLVVRDSSVRNVTCSTFNPILGQEKAMAMFLPEPFFPKVSPWKPAFFVTLTMMGLLVLGTSYLFRRERSARLIVQELTGNLQRVEDNKAEEDTVRTIDALMVELAQRKAAYRAAWRKAQLYADWRKEQFQAWTFTLDPASAHTNLAISQDRLTVTRKDFTRCLEDLSCVLGIRGISSGRYYWEVKLTNIEGSKWILGVCREGVVRKNFYFETPRKGFWTVGQSSKGHWAYIDSGRTSLSVRQAPKSVGVFVDYTEGDISFYNMSDMSHMFSFPKASFSGTLFPYFRLRSGNVSMIINSMECASESSEGEEGRRGRKRSRRGGRGGGGRMGRS
Protein: Cytochrome P450 704B1 (Long-chain fatty acid omega-hydroxylase) (EC 1.14.14.80) (Q9C788)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in pollen wall development. Catalyzes the conversion of long-chain fatty acids to the corresponding omega-hydroxylated fatty acids. Omega-hydroxylated fatty acids, together with in-chain hydroxylated fatty acids, are key monomeric aliphatic building blocks for sporopollenin synthesis during exine formation.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Type III polyketide synthase B
- Type III polyketide synthase A
- Tetraketide alpha-pyrone reductase 1
- 4-coumarate--CoA ligase-like 1
- Cytochrome P450 superfamily protein
- At3g10570
- Cytochrome P450 77A4
- Tetraketide alpha-pyrone reductase 2
- ABC transporter G family member 26
- Aldehyde dehydrogenase family 7 member B4
Sequence:
MSLCLVIACMVTSWIFLHRWGQRNKSGPKTWPLVGAAIEQLTNFDRMHDWLVEYLYNSRTVVVPMPFTTYTYIADPINVEYVLKTNFSNYPKGETYHSYMEVLLGDGIFNSDGELWRKQRKTASFEFASKNLRDFSTVVFKEYSLKLFTILSQASFKEQQVDMQELLMRMTLDSICKVGFGVEIGTLAPELPENHFAKAFDTANIIVTLRFIDPLWKMKKFLNIGSEALLGKSIKVVNDFTYSVIRRRKAELLEAQISPTNNNNNNNNKVKHDILSRFIEISDDPDSKETEKSLRDIVLNFVIAGRDTTATTLTWAIYMIMMNENVAEKLYSELQELEKESAEATNTSLHQYDTEDFNSFNEKVTEFAGLLNYDSLGKLHYLHAVITETLRLYPAVPQDPKGVLEDDMLPNGTKVKAGGMVTYVPYSMGRMEYNWGSDAALFKPERWLKDGVFQNASPFKFTAFQAGPRICLGKDSAYLQMKMAMAILCRFYKFHLVPNHPVKYRMMTILSMAHGLKVTVSRRS
Protein: Bacterioferritin BfrB (EC 1.16.3.1) (Non-heme ferritin Ftn) (Nox19) (P9WNE5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Possible cargo protein of a type 1 encapsulin nanocompartment involved in protection against oxidative stress (Probable). Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. Retains ferroxidase activity inside the encapsulin nanocompartment with a slight decrease in rate. It is not known if this protein is normally found in the encapsulin nanocompartment.
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:24855650}. Note=Forms an approximately 12 nm shell inside the encapsulin nanocompartment, suggesting the latter encapsulates the entire 24-subunit homooligomer. {ECO:0000305|PubMed:24855650}.
Interaction partners:
- Bacterioferritin BfrA
- Multicopper oxidase MmcO
- Coproporphyrin III ferrochelatase
- Iron-dependent repressor IdeR
Sequence:
MTEYEGPKTKFHALMQEQIHNEFTAAQQYVAIAVYFDSEDLPQLAKHFYSQAVEERNHAMMLVQHLLDRDLRVEIPGVDTVRNQFDRPREALALALDQERTVTDQVGRLTAVARDEGDFLGEQFMQWFLQEQIEEVALMATLVRVADRAGANLFELENFVAREVDVAPAASGAPHAAGGRL
Protein: Ferredoxin--NADP reductase, chloroplastic (FNR) (EC 1.18.1.2) (P00455)
Organism: Spinacia oleracea (Spinach)
Function: May play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power.
Subcellular location: Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Stromal side {ECO:0000305}. Note=In the vicinity of the photosystem I in the non-stacked and fringe portion of the membrane.
Interaction partners:
Sequence:
MTTAVTAAVSFPSTKTTSLSARSSSVISPDKISYKKVPLYYRNVSATGKMGPIRAQIASDVEAPPPAPAKVEKHSKKMEEGITVNKFKPKTPYVGRCLLNTKITGDDAPGETWHMVFSHEGEIPYREGQSVGVIPDGEDKNGKPHKLRLYSIASSALGDFGDAKSVSLCVKRLIYTNDAGETIKGVCSNFLCDLKPGAEVKLTGPVGKEMLMPKDPNATIIMLGTGTGIAPFRSFLWKMFFEKHDDYKFNGLAWLFLGVPTSSSLLYKEEFEKMKEKAPDNFRLDFAVSREQTNEKGEKMYIQTRMAQYAVELWEMLKKDNTYFYMCGLKGMEKGIDDIMVSLAAAEGIDWIEYKRQLKKAEQWNVEVY
Protein: Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) (Q9Y6I3)
Organism: Homo sapiens (Human)
Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}.
Interaction partners:
- Epidermal growth factor receptor substrate 15
- Epidermal growth factor receptor substrate 15-like 1
- RalBP1-associated Eps domain-containing protein 2
- Epidermal growth factor receptor
- AP-2 complex subunit alpha-1
- Clathrin heavy chain 1
- Clathrin heavy chain 2
- Clathrin coat assembly protein AP180
- Huntingtin-interacting protein 1-related protein
- Intersectin-1
Sequence:
MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
Protein: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC) (P15567)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Bifunctional purine biosynthetic protein ADE1
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Orotidine 5'-phosphate decarboxylase
- 3-isopropylmalate dehydrogenase
- Amidophosphoribosyltransferase
- Phosphoribosylformylglycinamidine synthase
- Phosphoribosylglycinamide formyltransferase
- Adenylosuccinate lyase
- Uncharacterized protein C8E4.05c
- Histidinol-phosphate aminotransferase
Sequence:
MSEKQVVGILGGGQLGRMMVEAAHRLNIKCIILDAANSPAKQIDGGREHIDASFTDPDAIVELSKKCTLLTTEIEHINTDALAAVTKSVAVEPSPATLRCIQDKYLQKQHLQVFKIALPEFCDAPDQESVEKAGQEFGYPFVLKSKTLAYDGRGNYVVHQPSEIPTAIKALGDRPLYVEKFVPFSMEIAVMVVRSLDGKVYAYPTTETIQKDNVCHLVYAPARLPFSIQQRAQTLAMDAVRTFEGAGIYGVEMFVLQDGETILLNEIAPRPHNSGHYTIEACPTSQFEAHLRAICGLPFSEINTQLSTSTTHALMVNILGTDDPDYVSKIAKRSLSIPGATLHLYGKAESRKGRKMGHVTIISDSPQECERRYQMLLDVKDPVESPVVGIIMGSDSDLSKMKDAAVILDEFKVPYELTIVSAHRTPDRMVTYARTAASRGLRVIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSTLDGVDSLHSIVQMPRGVPVATVAINNSQNAGILACRILATFQPSLLAAMESFMDNMKEIVLEKADKLEKVGWKNYSA
Protein: Golgb1 protein (Q8CGE5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
LDSTLAQLAAFTKSMSSLQDDRDRVIDEAKKWERRFGDAIQTKEEEVRLKEENCIALKDQLRQMAIHMEELKITVSRLEHDKEIWESKAQTELQHHQKAYDKLQEENKELTSQLEDARQLYHDSKNELTKLESELKSLKDQTTDLNNSLEKCKEHENNLEGIIKQQEADIQNCKFSCEQLETDLAASRELTSRLHDEINAKEQKIISLLSGKEEAIQLAVEELHQQHSKEIKELENLLSQEEEENVALEEENKRALEKTNQLTEALEAIKKESFEQKAQLDSFVKSMSSLQDDRDRIVSDYRQLEERHLSAILEKDQLIQDAAAENNKLKEEMRGLRSHMDDLNSENAKLDAELVQYRRDLNEVIAIKDSQQKQLLDAQLQQNKELRNECTKLEERLKGLEAEKQSLQMSSDALQKEKQGLSKEIKNLQTQLTALQEEGTLGVYHAQLKAKEEELQRLNMALSSSQKRTADLEEELVCVQKEATRKVSEIEDQLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLTVTKENKDLMAQIQAFGRSMSSLQDSRDHATEELGDLKKKYDASLKELAQLKEWQDSSREGDVLSQAAFPLSTSENVLSRLEKLNQQLTSKDEQLLHLSSELESSHNQVQSISKAMTSLQNERDRLWSELEKFRKSEEGKQRAAAPSAASSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQMSQEMTELRPLKAQLQESQDQTKALQVMEEELRQENLSWQHELRQLRMEKNSWELHERRMKEQFLMAISDKDQQLGHLQSLLRELRSSSQAQILSTQYQRQASPETSASLDGSQKLVYETELLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNVLSTQLSDASQSLRENQHHYSNLFNHCAILEKEVQKLQAGPLNTDVAPGAPQEKNGMHRKSEPETTGEEQPSFSEVQQQLCNTKQDLRELKKLLEEERDQRLTAENALSLAKEQIRRLEHSEWESARTPIMGACGSQEQALLIDLPGHSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAIYFLMIHVLLVLCFTGHL
Protein: Flavin-containing monooxygenase (EC 1.-.-.-) (F4JY69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDFCWKREMEGKLAHDHRGMTSPRRICVVTGPVIVGAGPSGLATAACLKERGITSVLLERSNCIASLWQLKTYDRLHLHLPKQFCELPIIPFPGDFPTYPTKQQFIEYLEDYARRFDIKPEFNQTVESAAFDENLGMWRVTSVGEEGTTEYVCRWLVAATGENAEPVVPRFEGMDKFAAAGVVKHTCHYKTGGDFAGKRVLVVGCGNSGMEVCLDLCNFGAQPSLVVRDAVHVLPREMLGTSTFGLSMFLLKWLPIRLVDRFLLVVSRFILGDTTLLGLNRPRLGPLELKNISGKTPVLDVGTLAKIKTGDIKVCSGIRRLKRHEVEFDNGKTERFDAIILATGYKSNVPSWLKENKMFSKKDGFPIQEFPEGWRGECGLYAVGFTKRGISGASMDAKRIAEDIHKCWKQDEQLQCKLGKRMKRKFSESDCGGN
Protein: Receptor-like serine/threonine-protein kinase SD1-7 (EC 2.7.11.1) (Arabidopsis thaliana receptor kinase 1) (S-domain-1 (SD1) receptor kinase 7) (SD1-7) (Q39086)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of cellular expansion and differentiation. Mediates subcellular relocalization of PUB9 from nucleus to plasma membrane in a protein-phosphorylation-dependent manner. May be involved in the abscisic acid-mediated signaling pathway, at least during germination.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Protein BRASSINOSTEROID INSENSITIVE 1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Receptor like protein 23
- Elongation factor Tu, chloroplastic
- Elongation factor Tu
Sequence:
MRSVPNYHHSFFIFLILILFLAFSVSPNTLSATESLTISSNKTIISPSQIFELGFFNPASSSRWYLGIWYKIIPIRTYVWVANRDNPLSSSNGTLKISGNNLVIFDQSDRPVWSTNITGGDVRSPVAAELLDNGNFLLRDSNNRLLWQSFDFPTDTLLAEMKLGWDQKTGFNRILRSWKTTDDPSSGEFSTKLETSEFPEFYICSKESILYRSGPWNGMRFSSVPGTIQVDYMVYNFTASKEEVTYSYRINKTNLYSRLYLNSAGLLQRLTWFETTQSWKQLWYSPKDLCDNYKVCGNFGYCDSNSLPNCYCIKGFKPVNEQAWDLRDGSAGCMRKTRLSCDGRDGFTRLKRMKLPDTTATIVDREIGLKVCKERCLEDCNCTAFANADIRNGGSGCVIWTREILDMRNYAKGGQDLYVRLAAAELEDKRIKNEKIIGSSIGVSILLLLSFVIFHFWKRKQKRSITIQTPNVDQVRSQDSLINDVVVSRRGYTSKEKKSEYLELPLLELEALATATNNFSNDNKLGQGGFGIVYKGRLLDGKEIAVKRLSKMSSQGTDEFMNEVRLIAKLQHINLVRLLGCCVDKGEKMLIYEYLENLSLDSHLFDQTRSSNLNWQKRFDIINGIARGLLYLHQDSRCRIIHRDLKASNVLLDKNMTPKISDFGMARIFGREETEANTRRVVGTYGYMSPEYAMDGIFSMKSDVFSFGVLLLEIISGKRNKGFYNSNRDLNLLGFVWRHWKEGNELEIVDPINIDSLSSKFPTHEILRCIQIGLLCVQERAEDRPVMSSVMVMLGSETTAIPQPKRPGFCIGRSPLEADSSSSTQRDDECTVNQITLSVIDAR
Protein: Protein CPR-5 (Protein constitutive expression of pathogenesis-related genes 5) (Protein constitutive expression of PR genes 5) (Protein hypersenescence-1) (Q9LV85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in transcriptional processes. Regulates negatively the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (pcd). Negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI). Promotes cell division and endoreduplication (e.g. in trichomes).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:21875893, ECO:0000269|PubMed:25455564}.
Interaction partners:
- Protein ACCELERATED CELL DEATH 6
- Cyclin-dependent protein kinase inhibitor SMR1
- Regulatory protein NPR1
- Nucleoporin
- Isochorismate synthase 1, chloroplastic
- Protein EDS1
- Lipase-like PAD4
- Cyclic nucleotide-gated ion channel 2
- Nuclear pore complex protein NUP88
- Pathogenesis-related protein 5
Sequence:
MEALLLPPSPEPQNQITNPANSKPNHQSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDNDEASSSYCSTSSTSNSNSTKRVTRVVHRLRNPMRLGMARRSVGERQAEKLAKPLGFSLAAFANMVIARKNAAGQNVYVDDLVEIFATLVEESLANVYGNKLGSFATNFEQTFSSTLKILKLTNECANPHQSNNNDGGSCNLDRSTIDGCSDTELFERETSSATSAYEVMQGSATATSLMNELALFEETLQLSCVPPRSSAMALTTDERFLKEQTRANDLKTVEIGLQIRELRCKETALGLKFESNNLGKAALELDVSKAAFRAEKFKTELEDTRKEEMVTRIMDWLLVSVFSMLASMVLGVYNFSIKRIEDATSVCDQSEEKSSSWWVPKQVSSINSGFNTFICRVRVWVQIFFGVLMIIVFTYFLNKRSSGTKQTMPISFIVLFLGIFCGVSGKLCVDTLGGDGKLWLIVWEVFCLLQFVANVFTLALYGLMFGPINVTQETRSNRCNSMFPYWARRSVVYVVILFVLPVINGLLPFATFGEWRDFAMYHLHGGSDYA
Protein: Calcium-binding protein KRP1 (KIC-related protein 1) (O81831)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor that binds calcium in vitro.
Interaction partners:
- DNA repair protein RAD4
- VQ motif-containing protein
- Transcription and mRNA export factor ENY2
- Uncharacterized protein At4g36500
- Calmodulin-like protein 5
- At5g54130
- Enhanced ethylene response protein 5
- SAC3 family protein B
- SAC3 family protein C
Sequence:
MASPKSPTRPTQQNPQPNFHDFLPTMAGNLGGEGLIGELCNGFELLMDREKGVITFESLRRNAAAVLGLGDLTDEDVRCMIKEGDFDCDGALNQMEFCVLMFRLSPDLMEASRCLVTEVIEEEFGFTRRH
Protein: Protein boule (Q24207)
Organism: Drosophila melanogaster (Fruit fly)
Function: RNA-binding protein that plays a central role in spermatogenesis. Required for meiotic entry and germline differentiation, at the transition between G2 and M phases of meiosis I. Acts by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR. Essential for translation of twine (twe) mRNA. Required for the expression of various genes such as CG6784, CG17210, CG15841 scpr-B, scpr-C, and rho-6.
Subcellular location: Nucleus {ECO:0000269|PubMed:9882490}. Cytoplasm {ECO:0000269|PubMed:9882490}. Note=Nuclear in primary spermatocytes until near the end of the meiotic prophase and cytoplasmic localization from then onward.
Interaction partners:
- Cdc25-like protein phosphatase twine
- LD31543p
- FI20148p1
Sequence:
MHKIAAAPPPSATPGGGLETPLAAPKYGTLIPNRIFVGGISGDTTEADLTRVFSAYGTVKSTKIIVDRAGVSKGYGFVTFETEQEAQRLQADGECVVLRDRKLNIAPAIKKQPNPLQSIVATNGAVYYTTTPPAPISNIPMDQFAAAVYPPAAGVPAIYPPSAMQYQPFYQYYSVPMNVPTIWPQNYQENHSPLLHSPTSNPHSPHSQSHPQSPCWSIEDLRDTLPRV
Protein: Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) (P54279)
Organism: Mus musculus (Mouse)
Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P54278}.
Interaction partners:
- DNA mismatch repair protein Mlh1
- DNA mismatch repair protein Msh2
- DNA mismatch repair protein Msh6
- DNA mismatch repair protein Msh3
- Exonuclease 1
- Fanconi anemia group J protein homolog
- MutL homolog 3
- Fanconi-associated nuclease 1
- DNA polymerase delta catalytic subunit
- Serine-protein kinase ATM
Sequence:
MEQTEGVSTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATTIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHGSASVGTRLVFDHNGKITQKTPYPRPKGTTVSVQHLFYTLPVRYKEFQRNIKKEYAKMVQVLQAYCIISAGVRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLIPFVQLPPSDAVCEEYGLSTSRTPQNLFYVSGFISQCTHGAGRSATDRQFFFINQRPCDPAKVSKLVNEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDANKLNVNQQPLLDVEGNLVKLHTAELEKPVPGKQDNSPSLKSTADEKRVASISRLREAFSLHPTKEIKSRGPETAELTRSFPSEKRGVLSSYPSDVISYRGLRGSQDKLVSPTDSPGDCMDREKIEKDSGLSSTSAGSEEGFSTPEVASSFSSDYNVSSPEDRPSQETINCGDLDCRPPGTGQSLKPEDHGYQCKALPLARLSPTNAKRFKTEERPSNVNISQRLPGPQSTSAAEVDVAIKMNKRIVLLEFSLSSLAKRMKQLQHLKAQNKHELSYRKFRAKICPGENQAAEDELRKEISKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMCRPSRVRQMFASRACRKSVMIGTALNASEMKKLITHMGEMDHPWNCPHGRPTMRHVANLDVISQN
Protein: Small ribosomal subunit protein RACK1 (D6R9L0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEVVPLGSQTRERGSSPGAGRSGETQKNGGPSQEGSCQQGVGQPRGLPQKAGRGLQQASHLREAGEEAPWMRRKRPAGPAGAGTDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT