wanglab/gogpt-training-data huggingface dataset:
Protein: Spindle pole body component (Q584R6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000256|ARBA:ARBA00004267, ECO:0000256|RuleBase:RU363050}.
Interaction partners:
- Spindle pole body component
- Gamma tubulin complex component protein N-terminal domain-containing protein
- Gamma-tubulin complex subunit, putative
- Tubulin gamma chain
- Tubulin delta chain
Sequence:
MEELQCALLGFHSASLPFEILKDSPCDAGVTGTFSQLHPSERSLVGEVLPLGEMCQTLRALATDFAVGRTDGLYISAIASAVVQILRSYEESVRAAVTPSSVVSLRPTYFLAFSLIMEMVQQQKNADLLLVTIQSFLSNREIPQKFRLWMGEAVWMSLLYTIGHYVAHGVVLHGRRDFFISVKSKGGKEDHTLHSDLLPHGIPMELGLLILSVGKERRVLLSDAESHGKEYLEQLALGAQDEAADAVFRAIYHPSLCVNGFLVVDELETRVEETHALWSKALWLKVSKQVDLRKHIDAMRAMFLCHRGDFWHTFVETAFSTFVDDTISRSTVTEAVVNRTAADAFAYALEMSGLGDVRVFERFSTFVRLPIEAEEGEGSGTLRSIEDTARAILSCMRGLGLHYVPPRGLQLVVSPKAMEYYQRIFSFHIVRRFSLHALHSVRGLFSEALLTNKNPSPELRRAFAIMQLLLFLQTTLGYYLQVDVIVLRNAELDKAMAKCKSVQDAKRCLDRYVWHITEGSFIAEGSNALFSACEALFQCSFALYVLCKRYRLVSWAVEGSRIPIEVLAALAALETRVHQEIIAAFTGHLSGSSTRGNERALWARLDFNRFLSAGLYGGPSTVFQQPQRPVPSRSLSSSLKSLRGPTQSRLRGERTTKGTSSPTPKAGHR
Protein: Nucleolar RNA-binding protein, putative (Q57YF7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
Sequence:
MAPMFHGFEVVPGKEHKLVLEKHHSFHLSVVSVKHGVKGRSTLYVTVDGESFSLLTLDVSQQLMQTPVDIVFGYEQEVVFRVKGNAVLHCCGYQQESEGMLSAALSGSGEYDNAEEEEEEEEGEDTGLDDGDDMAGVPLTDGKKNGNAATKRQQVVDRTDDSDDDDDEDEEDDEDDEDDEDEDDEDEDEDDDDQEKEEDEDEEPPAKKQKVGKSEGHVAQQSKQQQRGVQEPPRNKSKPNFNGNNNDRKRGRF
Protein: Inositol phosphoceramide mannosyltransferase 2 (EC 2.4.-.-) (IPC mannosyltransferase 2) (Q9UT67)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: With imt1 and imt3, is required for the synthesis of mannosyl phosphorylinositol ceramide (MIPC). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole.
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Interaction partners:
- Mannan polymerase complex subunit mnn9
- Mannan polymerase II complex anp1 subunit
- Glutathione S-transferase omega-like 2
- Uncharacterized kinase C24B10.02c
- Initiation-specific alpha-1,6-mannosyltransferase
- Alpha-1,2-galactosyltransferase
- General alpha-glucoside permease
- Dolichol-phosphate mannosyltransferase
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 3
Sequence:
MVKVIYKFAVFAAVNFFLMSSIVLYFNNEFLMFADRCTKDIIPSEELRYLRQVLNDSIPSKDEPLPTLKLDSLNDISGEPVIPKIIHQTWKTTEVPEGWKGAQQSCIDLHPDYEYILWTDEMSRNFIADNYPWFLPYFDAYPFNVQRADVIRYFVLYHYGGNYIDLDDGCRQRLDSLLYYPVWVRRTDPVGVSNDVMGSVPHHPYFELIIQNLEKNAKSYWLPYLTIMLSTGPLSISFLWEKYKRQLPNPPAFYDHIRVLLERDYKFSNDSYFTFYEGSSWHNNDAGIILWANRHLAYVIVAGFCLYFILSYMFFSKLLDSRYVQRFVTSKRKQPTLPLALQEDV
Protein: Uncharacterized protein (Q384N5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRALRGGLVKRDVERLERELKSYTEQLERERVRLDVLRARQAGRADGKSGESESDAEKRRLTRENAALRRKLAKLRSNGGSMVRHPDVADLHNQTVAVLQEVRQINMEVESLGIAHSNLTTAIVEAQADERVRDDLRSKQYNEQHALRDRLKELNEEWRAVEKRDVQLHERCAALQKQVLFNVPEKEAAALRTEYEQQEESIKCLKKRHEYLKALNYGLLGEDKLSSTKEGRAKLNAEKKLRELRQLLESREKEYDNLKGTIHASYGRSR
Protein: Syntaxin-4 (P70452)
Organism: Mus musculus (Mouse)
Function: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Cell projection, stereocilium {ECO:0000269|PubMed:36355422}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850}.
Interaction partners:
- Vesicle-trafficking protein SEC22b
- Vesicle-associated membrane protein 7
- Syntaxin-binding protein 3
- Vesicle-associated membrane protein 2
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 4
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 1
Sequence:
MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLGSPDDEFFQKVQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLKAIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMIAICVSVTVLILAVIIGITITVG
Protein: Carnitine O-octanoyltransferase (C9J3D7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRC
Protein: Dual specificity protein phosphatase YVH1 (PfYVH1) (EC 3.1.3.16) (EC 3.1.3.48) (O77334)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Dual specificity protein phosphatase which dephosphorylates both phosphotyrosine and phosphoserine residues.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14698441}. Nucleus {ECO:0000269|PubMed:14698441}. Note=Localizes to the cytoplasm at the ring stage, translocates to the nucleus in the trophozoite stage and returns to the cytoplasm at the schizont stage. {ECO:0000269|PubMed:14698441}.
Interaction partners:
Sequence:
MIVKVFDYIYISNVYNANDIYELIKLNIGGVLTCFDCTCIEWCHHNDTNVTNKIFYKDIFVNTKKDLIKCDVPIITNKSVNSDIIGGTHQINNYYNEQNNNYHDNTYKEFTQTHKTNIDPSQIKSDHINEERKEHYDYIIFPSDIINNTQCNNNNLKDYIKSMLILKEDAYIDFDVIHMDQLKNKHNNNNNNNNNNNNNNNNNNNNNNCCTFKNPDISNTSQHHVEHIQIHKSNSHSNIPSDNINFCNKKYDKNLSRSVEISEKDKHPENSLLYEFVNKDKLNYKINQEEDTVSSEKNKLCDNNNNNNMVHTRHIYNVCELNKCLRENKLIPYNNIYKMKHLYLNILDTFDENILKHVNKAHLFIDSVIQKKKNILIHCMAGISRCSSIILSYVSKKNKKGIEYNFNLLKSKYPFAHPNENFYRQLLLYEKMNYTLDGCTDYHNIYKKIKMNRENLEELKILNLKNDKQPIYNFRCKHCNYVLFNDNEIIKHDFKISKIKKNYGNSCTSIFIEKKEWILTENKMKGVLNCPNVNCNIKLGKWSWTGICCSCGYLQIPAFMINSSNVDRMNISKTV
Protein: Putative BPI/LBP family protein At1g04970 (Q9MAU5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serinc-domain containing serine and sphingolipid biosynthesis protein
- Protein C2-DOMAIN ABA-RELATED 10
- GrpE-like protein
- Dormancy-associated protein homolog 4
Sequence:
MDVGRCFLFLLLPSFFFLPSQTQSTDSFTSVLVSQNGLDFVKNLLVNKAIASIIPLQIPRIEKSMKIPFLGGIDVVVSNLTIYELDVASSYVKLGETGVVIVASGTTCNLSMNWHYSYSTWLPPIEISDQGIASVQVQGMEIGLSLGLKSDEGGLKLSLSECGCHVEDITIELEGGASWFYQGMVNAFKDQIGSSVESTIAKKLTEGVSDLDSFLQSLPKEIPVDDNADLNVTFTSDPILRNSSITFEIDGLFTKGETNQVLKSFFKKSVSLVICPGNSKMLGISVDEAVFNSAAALYYNADFVQWVVDKIPEQSLLNTARWRFIIPQLYKKYPNQDMNLNISLSSPPLVKISEQYVGANVNADLVINVLDANQVIPVACISLMIRGSGALRVMGNNLGGSVSLEDFSMSLKWSNIGNLHLHLLQPIVWTVIQTVFVPYANDHLEKGFPLPIMHGFTLQNAEIICSESEITVCSDVAYLDSSQQPQWL
Protein: NADPH-dependent codeinone reductase 1-3 (PsCor1.3) (EC 1.1.1.247) (Q9SQ68)
Organism: Papaver somniferum (Opium poppy)
Function: Reduces codeinone to codeine in the penultimate step in morphine biosynthesis. Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11079569}. Note=Present in the cytosolic part of laticifer cells that secrete latex (PubMed:11079569). Localized to the parietal region of the sieve element cytoplasm (PubMed:14508000). {ECO:0000269|PubMed:11079569, ECO:0000269|PubMed:14508000}.
Interaction partners:
Sequence:
MESNGVPMITLSSGIRMPALGMGTAETMVKGTEREKLAFLKAIEVGYRHFDTAAAYQSEECLGEAIAEALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLDYLDLYLIHHPVSLKPGKFVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVCNFSCKKLQELMAAAKIPPVVNQVEMSPTLHQKNLREYCKANNIMITAHSVLGAICAPWGSNAVMDSKVLHQIAVARGKSVAQVSMRWVYQQGASLVVKSFNEGRMKENLKIFDWELTAENMEKISEIPQSRTSSADFLLSPTGPFKTEEEFWDEKD
Protein: Uncharacterized protein YOR289W (Q12012)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Putative uncharacterized protein YML089C
- Unfolded protein response-inducible protein 1
Sequence:
MALRLFRKSSFFAKISMEGPKGSSPFAFYAFYQLYSHLNPGKSSSLSLEDIRRRLYPDFKIDYNEKTSLFITWKKKSNKHHTIDTNEENYILRGCIGTFAKMPIAHGIEKYSLIAALEDRRFSPIQKRELVDLKCSCNILGNFKTIFRGGGNPNGDIFDWELGKHGIELYFKHPKTGTTCSATFLPDVMPEQHWNKEDTFANLIEKAGYWGNISEVMDNFETYFIEVIRYEGKKSSITYEEFNKQLKDIEA
Protein: IP10585p (Q9VAN9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- UDP-sugar transporter UST74c
- UDP-galactose transporter senju
- AMP deaminase
- GDP-fucose transporter, Golgi
- Solute carrier family 35 member B1 homolog
Sequence:
MNLSIRAISAICGVFLGCCSGVVFLELLVKLDPGAGNLITGAQFAFIALEGFIFTSKFGLAQRVISLRDYALLVAMFFLTSVCNNYVFKFKVPMTLHMIIRGGSLISNMCLCTLILKRSYRLSQYISVLMISVGIFVCTYFSSPDLVGKMENLDSGAEADTFWWLLGVALLVLALFVSSYMGITQELLYRRHGKCAREALYYTHLLPLPAFLLMHDDIRTHWLLAFTGESYQLPLLGVAVPLILLYLLGNVLAQHLCISSVYTLTTECSSLTVTLILTLRKFISLVFSIVYFRNPFTWWHWLGTALVFVGTLMFANVIRVPK
Protein: Multidrug resistance ABC transporter ATP-binding and permease protein (Q72J05)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTEDTYSKAFDRALFARILRYVWPYRLQVVLALLFLLVVTLAAAATPLFFKWAIDLALVPTEPRPLAERFHLLLWISLGFLAVRAVHFAATYGETYLIQWVGQRVLFDLRSDLFAKLMRLHPGFYDRNPVGRLMTRVTSDVDAINQFITGGLVGVIADLFTLVGLLGFMLFLSPKLTLVVLLVAPVLLAVTTWVRLGMRSAYREMRLRLARVNAALQENLSGVETIQLFVKEREREEKFDRLNRDLFRAWVEIIRWFALFFPVVGFLGDFAVASLVYYGGGEVVRGAVSLGLLVAFVDYTRQLFQPLQDLSDKFNLFQGAMASAERIFGVLDTEEELKDPEDPTPIRGFRGEVEFRDVWLAYTPKGVEPTEKDWVLKGVSFRVRPGEKVALVGATGAGKTSVVSLIARFYDPQRGCVFLDGVDVRRYRQEELRRHVGIVLQEPFLFSGTVLDNLRLFDPSVPPERVEEVARFLGAHEFILRLPKGYQTVLGERGAGLSTGEKQLLALVRALLASPDILLILDEATASVDSETEKRLQEALYKAMEGRTSLIIAHRLSTIRHVDRILVFRKGRLVEEGSHEELLAKGGYYAALYRLQFQEA
Protein: Protein IL-40 (Interleukin-40) (IL-40) (Q9CX63)
Organism: Mus musculus (Mouse)
Function: Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q6UX52}.
Interaction partners:
Sequence:
MALLQLLLFAMLAACGFSEEQTEGITIAYKVLEVYPQSRRVLITCDAPEASQPITYSLLASRGILVAKKVVHDSVPASFNINITIKSSPDLLTYSCQATSNSGTYGPSSRLQMYQELWAKPVSQLQADFVLRHGDSGPTVELSCLASSGSPPITYRLVGNGGRVLAQQRPLHGKPANFSLPLSQTTGWFQCEAENDVGVDSSARIPLPRAEARAKLVTTLAGELPLTPTCILAGSLVSIAVIASRMLSSTGL
Protein: Cellular retinoic acid-binding protein 2, b (Cellular retinoic acid-binding protein 2b) (Q5G9L7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- All-trans-retinol 13,14-reductase
- All-trans-retinol 13,14-reductase
Sequence:
MESNTEKTFADFSGSWKMKSSENFEELLKALGVNVFLRKIAVAAASKPAVEISQQGESLSVQTSTSVRTTHVSFTVGESFNETTVDGRPCTSFPKWETDCKISCEQTLQKGEGPETSWTRELTNDGQMILTMRAGDVVCTRVYERD
Protein: Uncharacterized protein C1271.08c (O94341)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLISRSSMPNLQKRHSDFKTPVYISRSISILNKIFHPCMYIYSRGITNDTYSSDTYELDWYDLGFVHFSKWVELAWCFLTLATWSFMKLLKTLRIVIYICTSDHWTHSLRFYYIELSKILLYLLICGVSLYGAIRIFINL
Protein: Medium/long-chain acyl-CoA thioesterase YigI (EC 3.1.2.20) (P0ADP2)
Organism: Escherichia coli (strain K12)
Function: Displays thioesterase activity against medium- to long-chain acyl-CoA substrates. Is involved in the thioesterase-dependent beta-oxidation pathway of (9Z,11E)-octadecadienoate (conjugated linoleic acid or CLA), along with TesB and FadM. In vitro, is active against decanoyl-CoA and palmitoyl-CoA (hexadecanoyl-CoA), but not with acetyl-, butyl- or benzoyl-CoA. Lacks general lipase or amidase activity. Likely plays an important and specific role under natural conditions in permitting the metabolism of unusual carbon sources.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35876515}.
Interaction partners:
- Protein RarD
Sequence:
MSAVLTAEQALKLVGEMFVYHMPFNRALGMELERYEKEFAQLAFKNQPMMVGNWAQSILHGGVIASALDVAAGLVCVGSTLTRHETISEDELRQRLSRMGTIDLRVDYLRPGRGERFTATSSLLRAGNKVAVARVELHNEEQLYIASATATYMVG
Protein: DNA-binding protein rap1 (Q96TL7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE). Unlike yeast, exhibits no effect in transcription regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}. Chromosome, telomere {ECO:0000269|PubMed:11676924, ECO:0000269|PubMed:19948484}.
Interaction partners:
- Protection of telomeres protein tpz1
- Telomere length regulator taz1
- Protection of telomeres protein poz1
- Bouquet formation protein 4
- Coiled-coil quantitatively-enriched protein 1
- Telomere bouquet protein 1
- Telomere bouquet protein 2
- Telomerase reverse transcriptase
- Protein stn1
- Protein ten1
Sequence:
MSFTFTKSDGSSILFAVSKNFEHIRGFKNAIDCFKGKIEFLSFDKVDPTKHDYYLVAEDERVSDLDIPKGFFERNPEFRHKMLKIAWITQCIEQGKLLPTESFEVELNQDDVNRTHDGFRKRELFTLEDEKILIDHVHKNDINRFGTKVYEELARKYPQHSLESWRQHYKYMKKRLPPVSDSDESNYCQRIIVKPYSSQKDYTQSTHEQTLSSPISKSASVSKSENKALVNNKRYSDSYFYFSKMRRISIDVDYVDEDLNLINAYLSQFGKKRSLNELCALLSRRFSNRHTFSEWRALFMHFFPFINSEGVDPAILSDRETSAMLDETSDNEVADIDDQMIERKYLFSASEPNTVKSTNRLIFSERKAYAADDSIDNTPSKVPIVNSLSDPRTNRPFFYSNPDSMYRSISNPLHLVDSQHLSPLNRKTHFNNPIGQPQFTCLDDHEKTLRETSFRSLDDMSLRKSNSDNIFVKPGEDLEIPLLSDYSDSENISEKSSDDEEAFEKQVTSSYSSPIKVKSQGKSSKGSSGLDVREHEGSDDDAEVFVDRSPESFGATKVAHTSLEGNAASHKKVEENMQQPVTKKQKKYRMVNEEAHTGPTIIIPSDNNEKVTTLPAGHVPSEEKGKFINLAMHELQNEVSILRSSVNHREVDEAIDNILRYTNSTEQQFLEAMESTGGRVRIAIAKLLSKQTS
Protein: Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) (Q9WTU0)
Organism: Mus musculus (Mouse)
Function: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:O75151}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O75151}.
Interaction partners:
- AT-rich interactive domain-containing protein 5B
Sequence:
MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGPTPDVKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWRSASNHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAAASSDEVCDGDREKEEPPSPVETTPPRSLLEKVSKKKTSKTVKMPKPSKIPKPPKSPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDMERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKALRPPSSPGVFGALQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKSAPKRDLSFLLDKKEALLMPTSKPKLDSAVYKSDDSSDEGSLHIDTDTKPGRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKIGGGNKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPAPNTASPSISTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFSGSQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
Protein: Forkhead box protein O4 (Fork head domain transcription factor AFX1) (P98177)
Organism: Homo sapiens (Human)
Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Subcellular location: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Interaction partners:
- Cellular tumor antigen p53
- RAC-alpha serine/threonine-protein kinase
- CREB-binding protein
- Histone acetyltransferase p300
- Ubiquitin carboxyl-terminal hydrolase 7
- Ataxin-3
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
- Serine/threonine-protein kinase Sgk1
- Mitogen-activated protein kinase 8
Sequence:
MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP
Protein: Amino acid transporter AATP5 (Q57WK1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSNVRGNITPAVVYASNEPNALNASDDGIKNYEAYEDIQSNNSESKFAPFSKLSKKIAAVIPPGGIFASAFNIAATTLGAGIFGLPSTANGSGLVMGILYLVIINCMTIYSMYNLALAAERSKALTYEGVTFVVLGRWAAYAIAAVRAFDGFTSCIAYVISVGDIFSSILKGTDAPEFWKGNTGNRLLTALLWLCCMLPLVIPRHVDSLRHVSTCAVTFMVYFVIVIVVHSCLNGLPENIKDVSVGKSDTAAIILFNSGNAAVEGLGVFMFSYTCQDTAYEIYMDMKDRSVRKFVISSAIAMCMCTVLYILTVFFGYMDFGRDVTGSILLMYDPVNEPAVMVGMIGVLVKLIASYALLAMACRNALYSIAGKNADVLPFWKHCASVVTLSVAALVLGLFIPKVNTVLGFAGSITGGSLGYIFPSLLLMYSGGFTWQRVGPFHYLVAYGLLISGVVGVVFGTGATIWGTIVG
Protein: Cullin (A0A1D8PDR1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- SCF ubiquitin ligase complex subunit
- COP9 signalosome complex subunit 5
- Cullin-associated NEDD8-dissociated protein 1
- DNA excision repair protein ERCC-8
- DNA damage-binding protein CMR1
- F-box protein COS111
- NEDD8 family protein
- JAB1/MPN/MOV34 metalloenzyme domain-containing protein
- Centrin
- Defective in cullin neddylation protein 1
Sequence:
MSIDDITDKILDFNNSSSSNTLSSLSTGNTRIPPQQRKLSHLVSNSPSSKLYQKSFEDDNVTNNTSDINNKHKNLNKPTNDELTTRIKSIQQLADRTIDSILKGLPLERSFGYLNYEFTKLCRYKHVEQSKLSDLIFEKIINDFKTNLKPSIIEILHDNYQDTDSIIQSVKNFLNLFTNWYFRMSDLSKVFIYLDNHYLVQHRTKHPIMSFAIDLFINEVFVEDKQLAKKVLNTEFQLLCKWREQIEIEMEIDDDDDEENDLINMDVIDQSLSFTTVLVDLHNQGFKFDFNEQLLSSIITHYNHLKISWLKNDPTTYLSKVLGTINENLRFFKAVGKNINFIKNLFMKLRWNLIFYDFNNLLPKVLPSLLKNEQELGIIYQYCCHSVEDFGYDSISIFIYQWGVYTKSVFESIVDVYDKSTKSSNNNVIEQVVNKYKELISLIITSLPDNDKFEFEVRNSLIKTINNTTSINSMIIYQLCKYCDNFFKGKSSSLLFPEFEKNVLIIFKSINNKQDFINFYKKDLSKRLLLLNQKFKFENEQKFINSLIKVVGENDDVLSLTVMFKDLTDSKDIYKSLITVPTANYTLLNNSFEFNPLILEKKQWPNIPNNEDLHEFKLPVVLQDILTEMTNQYQTLDVKYKNRQLDWTNYKLHQITMSAQFDQGEKEITGNLLQIVLLLLFTAEDDNGYTIEQLSSMTGINNTQFLTKIVNSITNDKYAILRYDGNRYYYNSSFKDKSTRIKLPMIKELSRSEQQQQQQEKQVKGMNDIDSVESTVQANRDDEIKSCVVKIMKQERQLTIIELLNKSISVLQNRRPVTMTNLKTIIENLIELEYLKRDDHNKNIIIYIP
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F6XUP1)
Organism: Macaca mulatta (Rhesus macaque)
Interaction partners:
- Cell division control protein 42 homolog
- Rho guanine nucleotide exchange factor 7
- Cytoplasmic protein
- small monomeric GTPase
- Rac/Cdc42 guanine nucleotide exchange factor 6
- Cytoplasmic protein
- small monomeric GTPase
- small monomeric GTPase
- LIM domain kinase 1
- non-specific serine/threonine protein kinase
Sequence:
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTSTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQPKGESCLRRSTGLSARGIRQENEKNLIHGFHASSTTNAMSPSLLAAIVAFGNSDNGKK
Protein: Putative alcohol dehydrogenase D (EC 1.1.1.1) (P9WQB9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.
Interaction partners:
- Putative acetyl-hydrolase LipR
- Putative oxidoreductase SadH
- Long-chain-fatty-acid--CoA ligase FadD13
- Putative FAD-containing monooxygenase MymA
- Probable diacyglycerol O-acyltransferase Tgs4
- Putative diacyglycerol O-acyltransferase Rv3087
- R2-like ligand binding oxidase
Sequence:
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGSFRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH
Protein: Alpha-soluble NSF attachment protein 2 (Alpha-SNAP2) (N-ethylmaleimide-sensitive factor attachment protein alpha 2) (Q9SPE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Binds to SNARE complex and then recruits NSF to disassemble it (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Vesicle-fusing ATPase
- Syntaxin-32
- VAMP-like protein YKT61
- Syntaxin-31
- Gamma-soluble NSF attachment protein
- VAMP-like protein YKT62
- Vesicle transport v-SNARE 12
- Syntaxin-21
- Vesicle transport v-SNARE 11
- Vesicle transport v-SNARE 13
Sequence:
MGDHLVRAEEFEKKAEKKLNGWGIFGSKYEDAADLLEKAANSYKLAKSWDQAGKAYLKLADCHLKSDSKHDAANAYAEAAKCYKKVDTNEAASCLERAVNIFCEIGRLNMAARYYKEIAEYYESDQKFEQAIAYFEKAAEFFQNEEVTTSANQCNLKVAQYAAQLEQYEKAIKIYEDIARHSLNNNLLKYGVKGHLLTAGMCHLCKADVVSITNALEKYQDLDPTFTGTRECKFLADLASAIDEEDIAKFTDVVKEFDSMTPLDSWKTTMLLRVKEKLKAKELEEDDLT