wanglab/gogpt-training-data huggingface dataset:
Protein: Serpin H1 (Collagen-binding protein) (F1QQ04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Collagen, type I, alpha 1a.
- Collagen alpha-1
Sequence:
MWVSSLIALCLLAVAVSGEDKKLSTHATSMADTSANLAFNLYHNVAKEKGLENILISPVVVASSLGMVAMGSKSSTASQVKSVLKADALKDEHLHTGLSELLTEVSDPQTRNVTWKISNRLYGPSSVSFAEDFVKNSKKHYNYEHSKINFRDKRSAINSINEWAAKTTDGKLPEITKDVKNTDGAMIVNAMFFKPHWDEKFHHKMVDNRGFLVTRSHTVSVPMMHRTGIYGFYEDTENRFLIVSMPLAHKKSSMIFIMPYHVEPLDRLENLLTRQQLDTWISKLEERAVAISLPKVSMEVSHDLQKHLGELGLTEAVDKSKADLSNISGKKDLYLSNVFHASSLEWDTEGNPFDPSIFGSEKMRNPKLFYADHPFIFLVKDNKTNSILFIGRLVRPKGDKMRDEL
Protein: Cytochrome c isoform 1 (Iso-1-cytochrome c) (Cytochrome c aerobic isoform) (P00044)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of ubiquinol-cytochrome c oxidoreductase. Cytochrome c then transfers this electron to the dinuclear copper A center (CU(A)) of the COX2 subunit of cytochrome oxidase, the final protein carrier in the mitochondrial electron-transport chain. Isoform 1 (CYC1) is the predominant cytochrome c during aerobic/normoxic growth.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289, ECO:0000269|PubMed:9866716}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c peroxidase, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome b
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
Sequence:
MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE
Protein: Inositol phosphorylceramide synthase regulatory subunit KEI1 (ICP synthase regulatory subunit KEI1) (KEX2-cleavable protein essential for inositol phosphorylceramide synthesis) [Cleaved into: KEI1N; KEI1C] (Q06346)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19726565}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19726565}.
Interaction partners:
- Inositol phosphorylceramide synthase catalytic subunit AUR1
- Inositolphosphotransferase 1
Sequence:
MRSSLLTLPKSFLGFMPLYLAVEIVLGISILNKCSGAYGILALFTGHPLDFMQWIAYLWSVFTLIVFSQGLYLIHKPNLLVFSQICVLYTIDTISTCFFTLWFTTQWFTLEDTANIDGNNALQSNPISTGKLTERGIDISKQSATESYEYTMTILITLVSLIFRFYFNFILASFVQELLHHPKYLVDRDDVEQNLKNKPIWKRLWAKSQKGCYKLCKNLLE
Protein: Thymopoietin a (A0A2R8Q454)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSEFLEDPSVLTKDKLKSALLANNVALPNGDQRKDVYVQLYLKNLTVQNKKSSGSPDVFSSDEELPPAPVVSNRSRSGRKATRKTDKVRPDDVDVTELSNEGLKDLLLKYGLNAGPIVEPVAPAPVTVPEPEVEAELIPVVERPVRSRGKTPVTSRTRSGQHTRVEKVSAIDQTPRAVERDVLKEIFPTENLNTPTGISATCRRPIRGAAGRPLIDTWLNESRQRLSDLKQTTSSSSFSSTSSYTESRSVPRVSSIPLSASKSTAPPTVKSRSRRSLPVWVQLVLLSAVAGFLFFIYQAMETNDVGLFKQSGTDDSTSK
Protein: Cell division control protein 24 (Calcium regulatory protein) (P11433)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.
Interaction partners:
- Cell division control protein 42
- Ras-related protein RSR1
- Guanine nucleotide-binding protein subunit beta
- Cyclin-dependent kinase inhibitor FAR1
- Bud emergence protein 1
- Serine/threonine-protein kinase STE20
- Guanine nucleotide-binding protein subunit gamma
- High osmolarity signaling protein SHO1
- Serine/threonine-protein kinase STE11
- Serine/threonine-protein kinase CLA4
Sequence:
MAIQTRFASGTSLSDLKPKPSATSISIPMQNVMNKPVTEQDSLFHICANIRKRLEVLPQLKPFLQLAYQSSEVLSERQSLLLSQKQHQELLKSNGANRDSSDLAPTLRSSSISTATSLMSMEGISYTNSNPSATPNMEDTLLTFSMGILPITMDCDPVTQLSQLFQQGAPLCILFNSVKPQFKLPVIASDDLKVCKKSIYDFILGCKKHFAFNDEELFTISDVFANSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAENQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLEILDKYRQQLLDSNLITSEELYMLFPNLGDAIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKMRVDESQRFIINNKLELQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKELEAALDISKNIARSINENQRRTENHQVVKKLYGRVVNWKGYRISKFGELLYFDKVFISTTNSSSEPEREFEVYLFEKIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNGSPHHSYHKRHSNSSSSNNIHLSSSSAAAIIHSSTNSSDNNSNNSSSSSLFKLSANEPKLDLRGRIMIMNLNQIIPQNNRSLNITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKARHHSSTSTTSSTAKSSSMMSPTTTMNTPNHHNSRQTHDSMASFSSSHMKRVSDVLPKRRTTSSSFESEIKSISENFKNSIPESSILFRISYNNNSNNTSSSEIFTLLVEKVWNFDDLIMAINSKISNTHNNNISPITKIKYQDEDGDFVVLGSDEDWNVAKEMLAENNEKFLNIRLY
Protein: Large ribosomal subunit protein eL27 (60S ribosomal protein L27) (P61354)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61353}. Cytoplasm {ECO:0000250|UniProtKB:P61353}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:A1XQU5}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:A1XQU5, ECO:0000250|UniProtKB:P61353}.
Interaction partners:
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein uL4
Sequence:
MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
Protein: Uncharacterized protein (Q384B8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BRCT domain-containing protein
- Leucine-rich repeat protein
- BD-FAE-like domain-containing protein
Sequence:
MVFSIPSYLCLGDRPKKVVDERLHGVNFLTSRPKTGHYPDALFDKEFRYVYNGDRYPDPETMARREQMENRKRYITATGFISVFRPKKGEGLGSNYGLLQQEPYIHMPDHPQTRGPQPFPKVKPRQIYTSPSKAGSYGTPGLAITDIGNEYIATIYDQERINAKKERDVWRQRMPPVPFKPVGRRGYTFDEGPATGVSMCYIMTCPFREKRVQPVMKHFIIDKMWLPAGYIPDRPPPVEYWEDPYNGFDPRVDPKSRLKKSEDSIFRTGFRGDNFFYTRSIVFRRL
Protein: Homeobox protein Meis2 (Meis1-related protein 1) (P97367)
Organism: Mus musculus (Mouse)
Function: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:9710595}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21059917}.
Interaction partners:
- Pre-B-cell leukemia transcription factor 1
- Homeobox protein DLX-2
- Pre-B-cell leukemia transcription factor 2
- Pre-B-cell leukemia transcription factor 4
- Paired box protein Pax-6
- Pre-B-cell leukemia transcription factor 3
- Protein cereblon
Sequence:
MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
Protein: L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (Hepatic serine dehydratase) (hSDH) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (P20132)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P09367}.
Interaction partners:
- Serine hydroxymethyltransferase, mitochondrial
- Serine hydroxymethyltransferase, cytosolic
- Alanine--glyoxylate aminotransferase
- Cystathionine beta-synthase-like protein
- Phosphoserine phosphatase
- Serine racemase
- Cystathionine gamma-lyase
- Branched-chain-amino-acid aminotransferase, cytosolic
- Serine dehydratase-like
- Branched-chain-amino-acid aminotransferase, mitochondrial
Sequence:
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
Protein: ADAM metallopeptidase with thrombospondin type 1 motif 6 (A0A286YCZ1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QQQHIYDHSHCGVSDLTGSGKPWWLNKTSSFPSLPPINDTHIHHRKRRSVSTERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVRLPNFIVTPV
Protein: Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) (Q06496)
Organism: Rattus norvegicus (Rat)
Function: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q06495}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10370077, ECO:0000269|PubMed:8691716, ECO:0000269|PubMed:9058191}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation (By similarity). {ECO:0000250|UniProtKB:Q60825, ECO:0000269|PubMed:8691716, ECO:0000269|PubMed:9058191}.
Interaction partners:
- Na
- Sodium-dependent phosphate transport protein 2C
- Sodium-dependent phosphate transport protein 2B
- Klotho
- Na
- Fibroblast growth factor 23
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Sodium/hydrogen exchanger 3
- Parathyroid hormone
- 1,25-dihydroxyvitamin D
Sequence:
MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGTTTYAISSLSPVALTEHSCPYGEVLECHDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTKLIIQLDKSVITSIAVGDESLRNHSLIRIWCQPETKEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL
Protein: p2 aminopurine transporter (B2ZWB0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLGFDSANEFIVYVTFLFFGMSVVVVTNSIFSMPFFFIEYYKYAQGKPDAKPEDPKFWKHMFTYYSIAAFLVELVLASLMLTPIGRRISVTVRLGVGLVIPIVLVFSVMMVTIVTTTETGAKVTIMLIAIANGVAMTLCDAGNAALIAPFPTKFYSSVVWGIAVCGVVTSFFSIVIKASMEGGYHNMLIQSRIYFGLVMFMQVISCALLVLLRKNPYAQKYAAEFRYAARKGIDDKGAGGDEGNGAAKGPADQDDDPHGGDDTDKGNVMTATVDPDTMKDMDQVENITTSQQMLMARVWNVFWRVWPMLFACFMVFFTTFLVYPAVYFAIKADTGDGWYLTIAAALFNLGDFLSRLCLQFKALHVSPRWVLIGTFARMLLIIPLVLCVRSIITGPWLPYILVHAWGFTYGYYGGISQIYAPRTGSLTTAGERSLAANWTIISLLGGIFVGAMFALAVNEGLPK
Protein: Sialoadhesin (J9S2W1)
Organism: Sus scrofa (Pig)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MDFLLLLLLLASSALAGLASWTVSSPETVQGIKGSCLIIPCTFGFPANVEVPHGITAIWYYDYSGKRLVVSHSRNPKVVENHFQGRALLLGQVEQRTCSLLLKDLQPQDSGSYNFRFEISEGNRWSDVKGTVVTVTEVPSVPTIALPAKLHEGMEVDFNCSTPYVCPTEPVNLQWQGQDPTRSVTSHLQKLEPSGTSHMETLHMALSWQDHGRILSCQVSAAERRMQKEIHLQVQYAPKGVEILFSHSGRNVLPGDLVTLSCQVNSSNPQVSSVQWVKDGTKLKDQKRVLQLRRAAWADAGVYTCQAGNAVGSSVSPPVSLHVFMAEVQVSPVGSILENQTVTLACNTPKEAPSELRYSWYKNHALLEGSHSRTLRLHSVTRADSGFYFCEVQNARGRERSPPVSVVVSHPPLTPDLTAFLETQAGLVGILQCSVVSEPPATLVLSHGGLILASTSGEGDHSPRFSVASAPNSLRLEIQDLGPTDSGEYMCSASSSLGNASSTLDFHANAARLLISPAAEVVEGQAVTLSCRSSLSLMPDTRFSWYLNGALILEGPSSSLLLPAASSTDAGSYHCRAQNSHSTSGPSSPAVLTVLYAPRQPVFTAQLDPDTAGAGAGRQGLLLCRVDSDPPAQLQLLHRGRVVASSLSWGGGCCTCGGCFHRMKVTKAPNLLRVEIRDPVLEDEGVYLCEASSALGNASASATLDAQATVLVITPSHTLQEGIEANLTCNVSREASGPANFSWFRDGALWAQGPLDTVTLLPVARTDAALYACRIVTEAGAGLSTPVALNVLYPPDPPKLSALLDVDQGHTAVFVCTVDSRPLAQLALFRGEHLLAASSALRLPPRGRLQAKASANSLQLEVRDLSLGDSGSYHCEATNILGSANTSLTFQVRGAWVRVSPSPELQEGQAVVLSCQVPIGVLEGTSYRWYRDGQPLQESTSATLRFAAITLSQAGAYHCQAQAPGSATTDLAAPVSLHVTYAPRQATLTTLMDSGLGRLGLLLCRVNSDPPAQLRLLHGSRLVASTLQGVEELAGSSPRLQVATAPNTLRLEIHNAVLEDEGVYTCEATNTLGQTLASAAFDAQAMRVQVWPNATVQEGQLVNLTCLVWTTHLAQLTYTWYRDQQQLPGAAHSILLPNVTVTDAASYRCGILIPGQALRLSRPVALDVLYAPRRLRLTHLLESRGGQLAVVLCTVDSRPAAQLTLSHAGRLLASSTAASVPNTLRLELWEPRPSDEGLYSCSARSPLGQANTSLELRLEGVQVALAPSATVPEGAPVTVTCEDPAARPPTLYVWYHNSRWLQEGSAASLSFPAATRAHAGAYTCQVQDAQGTRISQPAALHILYAPRDAVLSSFWDSRASPMAVVQCTVDSEPPAEMTLSHDGKVLATSHGVHGLAVGTGHVQVARNALQLRVQNVPSRDKDTYVCMDRNSLGSVSTMGQLQPEGVHVVAEPGLDVPEGTALNLSCRLPSGPGHIGNSTFAWFRNGRQLHTESVPTLTFTHVARAQAGLYHCQAELPAGAATSAPVLLRVLYPPKTPTMTVFVEPEGGIQGILDCRVDSEPLASLTLHLGSRLVASSQPQAAPAKPHIRVSASPNALRVDMEELKPSDQGEYVCSASNALGSASAATYFGTRALHRLHLFQHLLWFLGLLASLLFLLLGLGVWYAWRRGNFYKLRMGEYSVEMVSRKETTQMSTDQEEVTGIGDDAGSVNQAAFDPAHLCENTQSVKSTV
Protein: Gap junction protein (A0A654IBU3)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
Sequence:
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
Protein: Hemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C) (Q8N7M5)
Organism: Rattus norvegicus (Rat)
Function: Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Also released in the extracellular space. {ECO:0000250|UniProtKB:Q6ZVN8}.
Interaction partners:
- Neogenin
- Transferrin receptor protein 2
- Hereditary hemochromatosis protein homolog
- Transferrin receptor protein 1
- Bone morphogenetic protein 6
- Bone morphogenetic protein receptor type-1A
- Transmembrane protease serine 6
- Activin receptor type-1
- Serine/threonine-protein kinase receptor
- Bone morphogenetic protein 2
Sequence:
MGDRGRSPSLRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSFTLSLRGGGSPDTPRGGGRGGPASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTASPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRTPGFLHCASFGDPHVRSFHNHFHTCRVQGAWPLLDNDFLFVQATSSPVASGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSVNGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIVRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQSALDDARVFLTDLENLHLFPVDAGPPLSPATCLVRLLSVLFVLWFCIQ
Protein: Uncharacterized protein (Q385L5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Uncharacterized protein
- GTP-binding protein, putative
- Pseudouridylate synthase RPUSD4, mitochondrial
- tRNA/rRNA methyltransferase SpoU type domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MKRLFPSAGVSVVLTSSSIVMSCPCNHIFISRRAYYWPYNEDFVPEGAETSRFQSSGSPGTRRRVLQEYALSPLFGARVPCCVVGTLRTAKEIIVLKRDIQSLLCELMELPQGSVTLGPLQQMREMMLYRHGTSLSPRLGDERQLNMDAYARRPIAARTMMDVFLAEDMSLDEIVNFGRLSLGKLQIALNNLRKESAEKSSADCEDGSAVEPAQLLVDRMGISYCEIPSLDESDYVFEEVGGVAVTDEEAERVAQRWAERCE
Protein: Small-subunit processome (P91280)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Protein BFR2
- Bms1-type G domain-containing protein
- U3 small nucleolar ribonucleoprotein protein MPP10
- Putative ATP-dependent RNA helicase rha-2
- RNA cytidine acetyltransferase
- KRR1 small subunit processome component
- WD repeat-containing protein 46
- WD_REPEATS_REGION domain-containing protein
- Nucleolar protein 6
- Nucleolar protein 14
Sequence:
MSDDSDLDDVAHQKLLQSIHTPGTVKKNRLKKASKTKTDATSLLSHLTVSRPSTNKAKQSLGIGGLESTEKTGKKRKSEATADETTTKKKLKSKTLIPLKDVEARKEIEGKIAFTDLKKEVTQNWTELVQSNRVSDQLIFPLTKPDGIMWGDEKTEPVLTEKEMELMKATDIKMAKDRLSQMQRMRAIVGIQEAKNRYMKKIKSKGYHRILKREKRKQLLKEFDDLVARDPSAAHEKLAEMDLQRIMERGSLKHRGQNQKFKQMLEKHASRNPEVKKLLDEHLRMGRELKAKVATTAEDSDGEAPTSTEDPQNKKKSIHELIKDAAQEAEKESRKQVGTALVDTFLEDSDAQKVTLAQMRAKKRQEAAITRSISANTGASRENPLFDVDDTWQEKEDAKKAKQKKKKLLKAKESARKGTIGKVSYVDKNYDPKMEAKRAETFDEKVEKAVDSAGVHAAEKRQKEIEIDPSKFLELNTNDLTQVSSDFVEKMDQFDEEAAQVINEAFKDDDVIGDFEDMKEGVKEKEKVKDVDLNLAGWGSWVGPGMTEKKRRQNFVIKAKEKRRRDGERNGVIIAENMTAKDGIGKIQPRSLPFPYSRVEDYEAVLKQPLGLEWNMEKMRDELCKPAVVVEAGRAIRPINKKHLLGE
Protein: Insulin-like growth factor 2 (Insulin-like growth factor II) (W5P082)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MSSDLPVGSRRWPCARRLGQGCPAGAEEMVSPDPQMTVVAPGAEPESTQVQRIEDGGTIIRIFWVGPKGELLRRTPVSSAIQTSMGITAGKSMLALLAFLAFASCCYAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPSSRINRRSRGIVEECCFRSCDLALLETYCAAPAKSERDVSASTTVLPDDFTAYPVGKFFQSDTWKQSTQRLRRGLPAFLRARRGRTLAKELEALREAKSHRPLIALPTQDPATHGGASSEASSD
Protein: RRM domain-containing protein (Q9XVS2)
Organism: Caenorhabditis elegans
Interaction partners:
- BED-type domain-containing protein
- Heterogeneous nuclear ribonucleoprotein K homolog
- Tar DNA-binding protein homolog 1
- Heterogeneous nuclear ribonucleoprotein A1
- RRM domain-containing protein
- RRM domain-containing protein
- Glucosamine 6-phosphate N-acetyltransferase
- Importin N-terminal domain-containing protein
- B30.2/SPRY domain-containing protein
- DZF domain-containing protein
Sequence:
MNRNRRDGPQRDVKRERRSRSRSPRRSRIGAAVGSNNGNSSSNNRMVFITNIAYEARWVDLKSLVREKGGEVAFCELLEDRNGKPKGNAVVEFETREGAEKCVENLQKFDWKGRTIIAKEIRDPNAFFRTIKTETGIDYLSRTGGGGAGGRGPPPKDLDRPTRTGTYDLFGLNMEFLRQHNIEPPLCERIFIANLAFNVGTDKLYEVFGMAGKITWMDFRIDKEGKSKGVCVIQYTHPIEAVQAVSMLNGQRLFDRNLVVKMDRFDKELEHKEGGLPRGLESIGMGLGAEGAPLSNVHGMFPGDASVPFTAPAAPFVGGPQVVSAGGFGGVVEQANFARSVMNNGPFGGNAGVGGAGGATFAQPDVFGVNGAGGLAGAATPQATRVIIIRNLPSDYTWQIVRDRVRNFGEVDSVDMMAPGAARIRFATFQDAERARAALYGSTVEGRMISVDYA
Protein: Alcohol acyltransferase 1 (AdAT1) (EC 2.3.1.-) (A0A068BGA5)
Organism: Actinidia deliciosa (Kiwi)
Function: Involved in the biosynthesis of volatile esters which confer kiwifruit flavor. Alcohol acyl transferase that can use a wide range of alcohols as substrate to produce esters. Exhibits benzoyl-CoA:alcohol O-acyltransferase activity.
Interaction partners:
Sequence:
MASFPPSLVFTVRRKEPILVLPSKPTPRELKQLSDIDDQEGLRFQVPVIMFYKRKLSTEGEDPVKVIREALAEALAFYYPFAGRLIEGPNRKLMVDCTSEGVLFIEADADIELNQLIGDTIDPGTYLDELLHDVPGSEGILGCPLLLIQVTRFRCGGWAFAIRLNHTMSDTLGLVQFLTTIAEFTRGAEGAPSVPPVWQREFLAARQPPFIPFQHHEYEQVIDTTPDDNKKSMTHKSFFFGPKEIRAIRSHLPLHHRSTSSTFDVLTACLWRCRTCALVLDPKKTVRISCAASGRGKHDLHVPRGYYGNVSAFPATVLRAGMISTSPLEYAMEGVKKAKARMTGEYLRSVADLMVTKGRPLYTVVGNYIVSDMTRVGLDTIDFGWGKPVYGGPARAFPLISFYGRFKDNKGEDGIVVLICLPEAAMKRFQEELKKMTGEHVDGPFDYKPIKVVSKL
Protein: Nuclear receptor co-repressor 2 (D3ZXN9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Histone deacetylase 3
- Paired amphipathic helix protein Sin3a
- BCL6, transcription repressor
- Histone deacetylase 2
- Estrogen receptor
- Histone deacetylase 4
- Histone deacetylase 1
- Peroxisome proliferator-activated receptor gamma
- Estrogen-related receptor gamma
- Recombining binding protein suppressor of hairless
Sequence:
MSGSTQPVAQTWRAAEPRYPPHGISYPVQIARPHTDVGLLEYQHHPRDYTSHLSPGSIIQPQRRRPSLLSEFQPGSERSQELHLRPESRTFLPELGKPDIEFTESKRPRLELLPDTLLRPAPLLATGQPSGSEDLTKDRSLAGKLEPVSPPSPPHADPELELTPSRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQRFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMDDPMKVYKDRQVTNMWSEQERDTFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQQMARSSQEEKEEKEKEKEADKEEEKQDAENEKEELSKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANHEETATPQQSSELASMEMNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKTPAAASEETAFPPAAEDEEMEASGASANEEELAEEAEASQASGNEVPRVGECSGPAAVNNSSDTESVPSPRTEATKDAGPKPASTEALPAATQPPVPPPEEPATVPDEPCPAPDASGPPSPVASPPPAAPPAAVDKDEQDQAATVPQTEDAKEQKSEAEELVIDVGKTEEPEAPEEPPESVKSDHKEETEEEPEDKAKGPEAIETVSEAPLKVEEAGSKAAVTKGSSSGATQDSDSSATCSADEVDEPEGGDKGRLLSPRPSLLTPAGDPRASTSPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDTVPPKPAPPVPPPTQHLQPEGDVSQQSGGSPRGKCRSPVPPAEKEAEKASFFPAFPAEGPKLPTEPPRWTSGLPFPIPPREVIKTSPHAADPSAFSYTPPGHPLPLGLHDSARPVLPRPPISNPPPLISSAKHPGVLERQLGTISQQGMSVQLRVPHSEHAKAPMGPLTMGLPLAVDPKKLGTALGSTASGSITKGLPSTRTADGPSYRGSITHGTPADVLYKGTISRIVGEDSPSRLDRAREDTLPKGHVIYEGKKGHVLSYEGGMSVSQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRTITSASIEGLMGRAIPEQHSPHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPPRDLTETYKTRPLDPLGPLKLKPTHEGVVATVKEAGRSIHEIPREELRRTPELPLAPRPLKEGSITQGTPLKYDSGVPSSGSKKHDVRSIIGSPGRPFPALHPLDIMADARALERACYEESLKSRSGTSSGAGGSITRGAPVVVPELGKPRQSPLAYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVTGVDLYRGHIPLAFDPTSIPRGIPLEAAAAAYYLPRHLAPSPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAASAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAIDRLAYLPTAPPPFSSRHSSSPLSPGGPTHLAKPTATSSSERERERERERDKSILTSTTTVEHAPIWRPGTEQSSGAGGSSRPASHTHQHSPISPRTQDALQQRPSVLHNTSMKGVVTSVEPGTPTVLRWARSTSTSSPVRPAATFPPATHCPLGGTLEGVYPTLMEPVLLPKETSRVTRPERPRVDAGHAFLTKPPAREPASSPSKSSEPRSLAPPSSSHTAIARTPAKSLAPHHASPDLPAPTSASDLHREKTQSKPFSIQELELRSLGYHSGAGYSPDGVEPISPVSSPSLTHDKGLSKPLEELEKSHLEGELRHKQPGPMKLSGEAAHLPHLRPLPESQPSSSPLLQTAPGIKGHQRVVTLAQHISEVITQDYTRHHPQQLSGPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGTPARGSPHSEGGKRSPEPSKTVLSSSEDAIEPVSPPEGMTEPGHARSTAYPLLYRDGEQGEPRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNIGQPGTEIFNMPAITGAGLMTCRSQAVQEHASTNMGLEAIIRKALMGKYDQWEEPPPLGANAFNPLNASASLPAAAMPITTADGRSDHPLTSPGGGGKAKVSGRPSSRKAKSPAPGLAPGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLAAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE