wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein bL19m (54S ribosomal protein IMG1, mitochondrial) (Integrity of mitochondrial genome protein 1) (PetCR46) (P25626)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bL19m is essential for respiration.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein uS12m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL13m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL34m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL6m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein mL46
Sequence:
MWSRNVRLLGSWTRSYMVPATKRKTIPVYPPVQRIASSQIMKQVALSEIESLDPGAVKRKLISKKNKDRLKAGDVVRIVYDSSKCSYDTFVGYILSIDRKQLVQDASLLLRNQIAKTAVEIRVPLFSPLIERIDLLTPHVSSRQRNKHYYIRGTRLDVGDLEAGLRRKK
Protein: Snaclec coagulation factor IX-binding protein subunit A (IX-bp subunit A) (Q7LZ71)
Organism: Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Function: Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factor IX (F9) (but not factor X) in the presence of calcium with a 1 to 1 stoichiometry.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
DCPSGWSSYEGHCYKPFKLYKTWDDAERFCTEQAKGGHLVSIESAGEADFVAQLVTENIQNTKSYVWIGLRVQGKEKQCSSEWSDGSSVSYENWIEAESKTCLGLEKETGFRKWVNIYCGQQNPFVCEA
Protein: Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) (Q9Y561)
Organism: Homo sapiens (Human)
Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Subcellular location: Membrane {ECO:0000269|PubMed:12809483}; Single-pass type I membrane protein {ECO:0000269|PubMed:12809483}. Membrane, coated pit {ECO:0000269|PubMed:12809483}.
Interaction partners:
Sequence:
MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC
Protein: Prolylcarboxypeptidase (cDNA FLJ57232, highly similar to Lysosomal Pro-X carboxypeptidase (EC3.4.16.2)) (B7Z7Q6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
Protein: Odorant-binding protein 2a (Epididymal-specific lipocalin-13) (Q8K1H9)
Organism: Mus musculus (Mouse)
Function: Involved in the regulation of systematic glucose homeostasis and insulin sensitivity. Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Epididymal-specific lipocalin-8
Sequence:
MKSLLLTILLLGLVAVLKAQEAPPDDLVDYSGIWYAKAMVHNGTLPSHKIPSIVFPVRIIALEEGDLETTVVFWNNGHCREFKFVMKKTEEPGKYTAFHNTKVIHVEKTSVNEHYIFYCEGRHNGTSSFGMGKLMGRDSGENPEAMEEFKNFIKRMNLRLENMFVPEIGDKCVESD
Protein: Uncharacterized protein YIL092W (P40497)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YDL129W
- Tubulin-specific chaperone C
Sequence:
MVQMRSKNMAYESGTNNYSDTIANGNTLPPRSKKGHSGRRKRSETLPIACNNFCVTRQIDDDEQAFKMLDKVSHLKKFSAEDGDDNNIFVQWADDITDILFGLCCTGTFLKLLISSALSGRAKTWFDSTTEGIDDHVIKAYSFEKFLALLSEEFDGARSLRREIFTELLTLSIDSEKSLEAFAHKSGRLTPYYLSSGAALDLFLTKLEPQLQKQLENCAFPMTLNLALLITACEFAKRASNHKKYRYKNTRDSDICTPKSKNTAIVSKLSNTKTISKNKVIEKSDKKNYFDKNSQHIPDPKRRKQNEPGMRLFLVMDEEKNILTSRNVSANAYTSKNGHTNLSDLHTNLKNSKSQQCAVEPISILNSGSLVTGTINIDLINDEVLGTKEETTTYDERMDGNSRSLNERCCAVKKNSLQPITSNIFQKNAEIQGTKIGSVLDSGISNSFSSTEYMFPPTSSATVSNPVKKNEISKSSQVKDIAQFNPFMTNEKEKKLNPSESFKSPGVSMEINRLSRIAGLRNIPGNIYEDSKMLNLKTRKCYPLHNFAVRTRSAHFNDRPSNYISPHETINATLRSPASFDSIQCITRSKRVDAETNKATGSAKSENIETKSRKFPEVINPFLVNTTNKKESD
Protein: Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) (P20594)
Organism: Homo sapiens (Human)
Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24001744, ECO:0000269|PubMed:26980729}; Single-pass type I membrane protein {ECO:0000305|PubMed:26980729}.
Interaction partners:
- Natriuretic peptides A
- C-type natriuretic peptide
- Natriuretic peptides B
- Atrial natriuretic peptide receptor 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Bis
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- Inosine triphosphate pyrophosphatase
Sequence:
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL
Protein: Zinc finger protein CONSTANS (Q39057)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that acts in the long day flowering pathway and may mediate between the circadian clock and the control of flowering. Plays a role in the regulation of flowering time by acting on 'SUPPRESSOR OF OVEREXPRESSION OF CO1', 'TERMINAL FLOWER 1' and 'FLOWERING LOCUS T'. Also regulates P5CS2 and ACS10 (involved in proline and ethylene biosynthesis, respectively). Regulates the expression of NAKR1 by binding to the 5'-TGTG(N2-3)ATG-3' motif.
Subcellular location: Nucleus {ECO:0000269|PubMed:24127609, ECO:0000269|PubMed:27015278}.
Interaction partners:
- Protein FLOWERING LOCUS T
- Protein GIGANTEA
- Nuclear transcription factor Y subunit C-9
- Adagio protein 3
- MADS-box protein FLOWERING LOCUS C
- Glycosyltransferase
- AT5g15260/F8M21_150
- Nuclear transcription factor Y subunit C-3
- Protein FD
- Protein TWIN SISTER of FT
Sequence:
MLKQESNDIGSGENNRARPCDTCRSNACTVYCHADSAYLCMSCDAQVHSANRVASRHKRVRVCESCERAPAAFLCEADDASLCTACDSEVHSANPLARRHQRVPILPISGNSFSSMTTTHHQSEKTMTDPEKRLVVDQEEGEEGDKDAKEVASWLFPNSDKNNNNQNNGLLFSDEYLNLVDYNSSMDYKFTGEYSQHQQNCSVPQTSYGGDRVVPLKLEESRGHQCHNQQNFQFNIKYGSSGTHYNDNGSINHNAYISSMETGVVPESTACVTTASHPRTPKGTVEQQPDPASQMITVTQLSPMDREARVLRYREKRKTRKFEKTIRYASRKAYAEIRPRVNGRFAKREIEAEEQGFNTMLMYNTGYGIVPSF
Protein: Allatostatin A receptor 2, isoform A (Allatostatin A receptor 2, isoform C) (Allatostatin G-protein coupled receptor) (RE51580p) (Q9NBC8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Allatostatin-A
Sequence:
MENTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSCARTSTTGL
Protein: GatB/YqeY domain-containing protein (O69656)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MAELKSQLRSDLTQAMKTQDKLRTATIRMLLAAIQTEEVSGKQARELSDDEVIKVLARESRKRGEAAEIYTQNGRGELAATEHAEARIIDEYLPTPLTEGELADVADTAIAEVAEELGHRPSMKQMGLVMKAATVIAAGKADGARLSAAVKERL
Protein: 2-oxo-acid reductase (EC 1.1.99.30) ((2R)-hydroxycarboxylate-viologen-oxidoreductase) (HVOR) (Q9R4Y1)
Organism: Proteus vulgaris
Function: Oxidoreductase with an extremely broad substrate specificity that can reduce reversibly 2-oxocarboxylates to (2R)-hydroxycarboxylates.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8026480}.
Interaction partners:
- Putative oxidoreductase.
- Hypothetical protein.
- 4Fe-4S dicluster domain protein.
- Hydrogenase-4 component A.
- Frd operon probable iron-sulfur subunit A
- Prokaryotic cytochrome b561 family protein.
Sequence:
MINGWTGNILRINLTTGAIS
Protein: Adenosine receptor A1 (P25099)
Organism: Rattus norvegicus (Rat)
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Kininogen-1
- Adenosine receptor A3
- Adenosine receptor A2a
- Adora3 protein
- P2Y purinoceptor 1
- Appetite-regulating hormone
- Pro-neuropeptide Y
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
Protein: Erythrocyte membrane protein band 4.1-like 3 (A0A0G2K1Q9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MPSSICLCSKSLLGFGEQSTMTTESGSDSESKPDQEAEPQEAAGPQEQAGAQAAPEPAGGNVEEQPGLEQFPEAAAHSTPVKREVSDKDRDFAAAAAKQLEYQQFEDDKLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGNDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDRRKKAEEATPVAALRHEGKTDSERTDTAADGETSATESDQEEDAELKAQELDKTQDELVKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTETIETEVEPTPHPQPLSTEKVLQETVLVEERHVMNVHASGDASHTARDDVDATESAPADRHSGNGKEGSSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVESISVGSVSPGGVKLETSTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED
Protein: Serine protease/ABC transporter B family protein tagB (EC 3.4.21.-) (Prestalk-specific protein tagB) (P54683)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Intercellular communication via tagB may mediate integration of cellular differentiation with morphogenesis.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MKFQFSSPSKIFLFSSVILILIFIGIKFELLEDTNSNRNDKFNNIINRFINYNIDDSIYKNKQQQQQFSNKIYSNEKKILLKNKIIDTTIKPSININNNNNNNNKLNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYNSIEYYSSFVSRLLKSNDDDGIYYDDYQSKYKKNHYIVQFKDRINDETREQLKEFLIGTDITILKEQPFKSHIVHYIPHDSFLVFMTKEQSVLLSSKEWISWIGEHEPSNKIHLNYHEKSIGYPVYIILSGSTNSLIQRWENTLNSILTSYNSKVKLTLINQKKLKSIVYCNDESPSSSSSSSCSLIGSEKIVYKWISEQSESNYIERSEKLQTANRLSPTVIFGTKDKLVNNDRIDIPLRGKGQILSIADTGLDGSHCFFSDSKYPIPFNQVNENHRKVVTYITYHDNEDYVNGHGTHVCGSAAGTPEDSSWAISSFSGLATDAKIAFYDLSSGSSEPTPPEDYSQMYKPLYDAGARVHGDSWGSVSLQGYYGGYSDDAGGIDAFLYEYPEFSILRAAGNNELFASLLAQATAKNAITVGAEQTAHVNYVSDALEYYDFSDNANFQRPCLFDKKYCNYTTAKCCSEVSNVKGLQLCCPASIKQNASDSFTTQPQFYNENNMGSFSSKGPTHDGRLKPDIVAPGEYITSARSNGENSTDQCGDGSLPNANGLMSISGTSMATPLATAATTILRQYLVDGYFPTGESVEENKLLPTGSLLKALMINNAQLLNGTYFWSASSTNPSNAIFEQINGANLIQGWGALRMNNWLYVKSSNPTPPSRWIGIGGLGKNQKATEWKEDSLSSGLNKSYCFTYKPSSSSSGSGGGGGTPRIVATLVWTDPPSYSGAKFNLVNNLDLLLLNSDDDSIITIGNSGGSLQPAGKVAQPDTLNNVEGIIINPTKAMNYKFTIAGTNVPIGPQKFSFVFHGENGQFDWADSCPQCVDGVQFPCLITNGIGIQSCGSDLLWTKCIVQSCNEGYNYNSLKNTCDKFLSYNYIIIIVAGGTMVLIILLLMWIKYQEYKESKRDSFRRFDDGTGIFVRPKDKDAKVTPPDLYNLVSPFIIELTIATACSLVATAASILQPFYIGNIVNNIPTTKSIGEFKSDFIIIFILAFIEFLFTNVGSWISGIVNEKMVMRLQNKVFRALIAQDMGFFQRNNSALLMNVLIVDTPMLRSALTGILLSIATGVCKLVGSLVFIFTISWKLSLAFFAAVPILGLVTQIQSQFTKRLTRQLLFHNSKASQHGTESLTNMHVVTNYCKQEKEMVKYSDQLMNVFITARKLIITNTFAGTGKWLLIESLTFVILYFSAYLVIQKQFTVGLMISFSLYIGYVVDASSSLFGVYVSYIQCLASATRVFMILRSAPRKRTTLEEEEADRLAGLSGGGGGGGDNGDDKKDKQNIENGKDVLPSNIITPIDNVENSNGKQDDPNNNNNNIGNLDYSEQLDGVSTVADSTVGLTKRELKKQKEKEQKEYFKQTGISVAETPTFLPSSYTELTECRGEIEFKNVSFRYPTRPDVQVLHNINMKFEAGKCYGLVGPSGSGKSTTLELISKFYPLHGETGGKIYMDGIDIAKIRPNNLRSFVTNVHQHPFLFDATIGENIGYAIDNPTQEDIIEAAKLAYAHEFINDLPKKYDTQIGEAGNLSGGQKKRIAVARAICAKRKIMLLDEITAELDPESEEAITQSIKVLTQGHTVVMVAHKVAAVRDCDKIFVLEKGYLVEEGTHDELMANKGKYYRMFSEDKDDTPLQNNNNNKNNNNNNNNNEPSSSSTPPNDQPTPPPQEQQEQKNDQPPPPPPQEQQEQQEQQQQQQQEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNDQPPNDYDQVPPPPPLPSESPSPPTGNNDGQPLVQMDEENDEER
Protein: DnaJ homolog subfamily C member 17 (Q9NVM6)
Organism: Homo sapiens (Human)
Function: May negatively affect PAX8-induced thyroglobulin/TG transcription.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:D3ZSC8}. Nucleus {ECO:0000250|UniProtKB:D3ZSC8}. Note=Predominantly nuclear. {ECO:0000250|UniProtKB:D3ZSC8}.
Interaction partners:
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor SYF1
Sequence:
MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQKLDEKRKKVKLDLEARERQAQAQESEEEEESRSTRTLEQEIERLREEGSRQLEEQQRLIREQIRQERDQRLRGKAENTEGQGTPKLKLKWKCKKEDESKGGYSKDVLLRLLQKYGEVLNLVLSSKKPGTAVVEFATVKAAELAVQNEVGLVDNPLKISWLEGQPQDAVGRSHSGLSKGSVLSERDYESLVMMRMRQAAERQQLIARMQQEDQEGPPT
Protein: Ascaphin-3 (P0CJ27)
Organism: Ascaphus truei (Coastal tailed frog)
Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very week hemolytic activity.
Subcellular location: Secreted.
Interaction partners:
Sequence:
GFRDVLKGAAKAFVKTVAGHIANI
Protein: Mitogen-activated protein kinase kinase kinase zak-1 (Mitogen-activated protein kinase kinase kinase 20 homolog) (EC 2.7.11.25) (H2KZW3)
Organism: Caenorhabditis elegans
Function: Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to ribotoxic stress. Acts as the proximal sensor of ribotoxic stress: directly binds to the ribosome, thereby acting as a sentinel for colliding ribosomes (By similarity). Upon ribosome collisions, activates the stress-activated protein kinase signal transduction cascade, leading to programmed cell death (By similarity). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NYL2}. Nucleus {ECO:0000250|UniProtKB:Q9NYL2}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase mek-1
- Palmitoyltransferase
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Ubiquitin-conjugating enzyme E2 13
Sequence:
MSTPTSNESTSSSSNNSDQRVLFPDIQRDDIQVGDHIGVGTFGAVFSGNWTLPDGSQRTIALKKVFVLEKEAEILSKIRHKNIIQFYGICKATGNDFFIVTEYAEKGSLYDFIHSEESQSFASSSGGNSFDVVVKWASQIASGIQYLHYDAVDTIIHRDLKSKNVVLDKNLVCKICDFGTSKDLTHSCTAPSWGGTAAWMSPEMILQSEGLTTATDVWSYGVVLWEILSKEVPYKDYSEFRIFTMITQSGITLAIPPSCPAPLKQLMSNCWKMTPKDRANMRQIQGELNRLAGNQKVMDECEKFMGLEDWKTEIEKQEKNVEKMRKDLEKRREQLEIREKALKQRMKVEQAVLDSARHPPEDVHQWSEHHTSHWVETVLGRVANDKKFLDRVNAAVFRNRITGARLLGMTQNDLEHLGVHKVGSRIELMKMIRKLADTQKALHNFPTLEQAKRIEMTLKTEKEAAGQLANDVDIVIIVGMYVRKMNATRRKFKFYADSDWIDDTDIPAKSKSKHASSLIKTVCFSVLDENTKKPINEPACSISSGMTTNPDWITVDTEDDVKIRVIVSVYYADIVTQPRNTEVIKVVTSLEESKILEERHVHLRLRRSSSSASISTPSPVIAPVYHPFGHLNNGFHHTTSSPQLRGFWHRKQTGMNRHGLTETELSSLQEQLRTPSPDKKVVDENVIIHVPKLTRRRRTTTTNSEDTEKSDTNNKTPESQARRVHVHGGKDKWNWKKGKSRPKFT
Protein: Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) (EPSP phospholyase) (P12008)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN.
Interaction partners:
- 3-phosphoshikimate 1-carboxyvinyltransferase
- T-protein
- 3-dehydroquinate synthase
- Bifunctional chorismate mutase/prephenate dehydratase
- Bifunctional protein TrpGD
- Anthranilate synthase component 1
- Shikimate kinase 1
- Shikimate dehydrogenase
- Isochorismate synthase MenF
- Shikimate kinase 2
Sequence:
MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLDIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
Protein: Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) (Q9Y608)
Organism: Homo sapiens (Human)
Function: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Interaction partners:
- Protein flightless-1 homolog
- Myeloid differentiation primary response protein MyD88
- Segment polarity protein dishevelled homolog DVL-1
Sequence:
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSRLSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ
Protein: Stress enhanced protein 1, chloroplastic (Q9M7I9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in non-photochemical quenching, a process that maintains the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage (By similarity). May play a photoprotective role in the thylakoid membrane in response to light stress (Probable).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:10725357}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Stress enhanced protein 2
- Light-harvesting complex-like protein OHP1, chloroplastic
- Kinesin-like protein KIN-14E
- Developmental protein SEPALLATA 3
- Photosystem II stability/assembly factor HCF136
- Photosystem I chlorophyll a/b-binding protein 3-1, chloroplastic
- Photosystem II 22 kDa protein, chloroplastic
- Chlorophyll a-b binding protein CP29.1, chloroplastic
- Protein CURVATURE THYLAKOID 1B, chloroplastic
- Floral homeotic protein APETALA 3
Sequence:
MALSQVSASLAFSLPNSGALKLATITNPTSTCRVHVPQLAGIRSTFASGSPLLPLKLSMTRRGGNRAASVSIRSEQSTEGSSGLDIWLGRGAMVGFAVAITVEISTGKGLLENFGVASPLPTVALAVTALVGVLAAVFIFQSSSKN
Protein: Myelin expression factor 2 (Q592E5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADTEQVADLTEIKDEETGDSPADECEQEPEQNQDDTNGDKTDTEDKSESKEKNSGGRKSHRYHPYKERSGGADKKTTHRNRVFISNIPYDKKWQAIKDLMREKVGEVTYVELFKDGEGKSRGCGVVEFKDEEFVKKAIEVMSKHDLNGRPLNIKEDPDGEHARRVLQRSGRMYGGGRGQDSSGINIPPSIANNPNIPHEIISALQAGRLGATIFVANLDFKVGWKKLKEVFGMAGTVRRADVKEDKDGKSRGMGTVTFEQPLEAVQAISMFNGQMLFDRQMHVKMDDKSLPPDDFRPVEKSPQLPRGLGGIGMGLGPGGQPINANCLSGSSMGPGGMDGGCSNMNRMSGMGGGFSGIDCMAGMGGFSGRDMSMGRMGDMYRSGMGGMDRDFGRNDLGMSRSFGDSFSSLGGGFGGMGNSGMGPMGSGLGMGNMGMDRMNSGFDRMSSSMDMSRGFGQFGGSGYMGGMSDRSKGGCQIFVRNLSYDLSWQKLKEKFSHCGQVMYAEIKMENGESKGCGTVRFDSPESAEKAFRLMNGTKINGREVDVRLDRNA
Protein: BcDNA.GH12174 (Q7KMJ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLLSLTDVMMIIFTLEAVYALSALGARPCSMLMQVRGLIDQLVTLITVEAQSYGTGGCILMRVVEVFPGNMAASLAQNMPAILAPGPTSLTTLPTSLQVAVKPPAVLPTPTPAQTQVLPHGEQTPLVTALPGLPMPSLPQVQLPVPSLPQVQLPPIAATVTLPSLPSASQSFTHEDEQYALAWLGATYERAGNGNDLRVEQAELYRIYLSHCQKAGKLSVVNHMQFPRLVRLIFNQSVGPVIVRHLDGIELPGTYYVGIRMRAQPLAMQQRPTPSIVPVKKDTPILPKQPFSDPVQTEVASEESVSSAVTPPPSSSLIKSLLANKVTERQQKQKAQAQTPQPPALVATTASGTNATQPIKVTSTAISAFVNNPLMQHTPVKVGQTTIKPLHPQMAIEKKPITDSAPPPLAPLSGANVVTKDASGRTLIIASAAAKRKLTIDEEQNKRLALDAAASSSSSSSSGGKEEAQVTPSKNAANLYADLAASILEDEDMDDVPPLAKPSQEQSQQHPQQAQQLQLIPAKVQPTQRQLVFPGSNVVSPAPHSQLKLATTATIKTDQGLQTVPVILQPKTAMDSTPAPQTQYVLATNQQGQTYLVAQQPTIPTSTQSAPPTLLVTQTPQQQTKTIIILQQPGGVSAANVAGTQKMIMTTAQGQQVLVTTTTAPQLAQPRTSTPQQQIFIAPQRPVPALGAGQMSPSLLSQLNQIPATIKLHQPQPQPQLVSPQLAPQQRLVAAKPGASLPIPQLQQHQSIIQQHIISGPSTPTSTVGGTVGGEKRQVILGGIKETTLITQTSATPAPLQQSQLNSQTIITQSPTSTAIVGGVALQQQHHIRSVLDQQQQHHPSIIQQKITMPAISEATKPKIAPVPVSPTVTLLAKKPAPPQPAQVSSPKPSVTQAVVVTTSGTSDSTEGGKTVVLATSEAKPAESEVVAQTVVPPAVVTTGPSSSSLVVSQSVYAASGPNANPTPSPMPVDANWLYICDWRNCPRKKFKSLNELQYHVCSVHCPDHLDSDADIYCQWGSGPNFCDNRARKRYSLMTHLIDRHLTTENLRASVQRRLATGIHNVAPTQAPVTIVRNEGHAQRLAGGATGSPSGPASAVPVVGSAAMQAMNRHTTDYTNAKELMDENEGPVTKSIRLTAALIIRNLVTYSATAKRSLKRYESRLANVAFSNVEASGVLSHIMYELSQ
Protein: EPH receptor A6 (H0Y9V0)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
XEEEEEEEDVDKDPHPTQNTCLRCRHFSLRERKREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHGASKGRCF