wanglab/gogpt-training-data huggingface dataset:
Protein: CRM1/XPO1 protein (Q9PW90)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCDGIKKYVVGLIIKTSSDATCVEKEKVYIGKLNMILVQILKQEWPKYWPTFISDIVGASRTSESLCQNNMVILKPLSEEVFDFSTGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQNAQLVHATLETLLRFLNWIPLGYIFETKLISTLVYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHGQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYADTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSSDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMATIVNKLGVHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTHFFLLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILYTLLQNVAQEEAAAQSFYQTYFCDILQHTFSVVTDTSHTAGLTMHASILAYMFNLVEEGKINTPLNQASPLNNQLFIQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIAAFKEHLRDFLVQIKEYAGEDTSDLFLEERESSLRQAQEEKHKLQMSVPGILNPHEIPEEMCD
Protein: Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) (P30120)
Organism: Rattus norvegicus (Rat)
Function: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Subcellular location: Secreted {ECO:0000269|PubMed:1309971, ECO:0000269|PubMed:7777858}.
Interaction partners:
- Matrix metalloproteinase-9
- Matrix metalloproteinase-14
- Stromelysin-1
- CD63 antigen
- 72 kDa type IV collagenase
- interstitial collagenase
- Macrophage metalloelastase
- Collagenase 3
- Matrilysin
- Neutrophil collagenase
Sequence:
MAPFASLASGILLLLSLIASSKACSCAPTHPQTAFCNSDLVIRAKFMGSPEIIETTLYQRYEIKMTKMLKGFDAVGNATGFRFAYTPAMESLCGYVHKSQNRSEEFLIAGRLRNGNLHITACSFLVPWHNLSPAQQKAFVKTYSAGCGVCTVFPCSAIPCKLESDSHCLWTDQILMGSEKGYQSDHFACLPRNPDLCTWQYLGVSMTRSLPLAKAEA
Protein: Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1) (P37268)
Organism: Homo sapiens (Human)
Function: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02769}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Squalene monooxygenase
- Lanosterol 14-alpha demethylase
- Lathosterol oxidase
- Farnesyl pyrophosphate synthase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Methylsterol monooxygenase 1
- Lanosterol synthase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Geranylgeranyl pyrophosphate synthase
- Ergosterol biosynthetic protein 28 homolog
Sequence:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
Protein: Probable LRR receptor-like serine/threonine-protein kinase At1g12460 (EC 2.7.11.1) (C0LGE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MRKVHLFLVLVHFIYISTSRSDSISERDILLQFKGSISDDPYNSLASWVSDGDLCNSFNGITCNPQGFVDKIVLWNTSLAGTLAPGLSNLKFIRVLNLFGNRFTGNLPLDYFKLQTLWTINVSSNALSGPIPEFISELSSLRFLDLSKNGFTGEIPVSLFKFCDKTKFVSLAHNNIFGSIPASIVNCNNLVGFDFSYNNLKGVLPPRICDIPVLEYISVRNNLLSGDVSEEIQKCQRLILVDLGSNLFHGLAPFAVLTFKNITYFNVSWNRFGGEIGEIVDCSESLEFLDASSNELTGRIPTGVMGCKSLKLLDLESNKLNGSIPGSIGKMESLSVIRLGNNSIDGVIPRDIGSLEFLQVLNLHNLNLIGEVPEDISNCRVLLELDVSGNDLEGKISKKLLNLTNIKILDLHRNRLNGSIPPELGNLSKVQFLDLSQNSLSGPIPSSLGSLNTLTHFNVSYNNLSGVIPPVPMIQAFGSSAFSNNPFLCGDPLVTPCNSRGAAAKSRNSDALSISVIIVIIAAAVILFGVCIVLALNLRARKRRKDEEILTVETTPLASSIDSSGVIIGKLVLFSKNLPSKYEDWEAGTKALLDKENIIGMGSIGSVYRASFEGGVSIAVKKLETLGRIRNQEEFEQEIGRLGGLQHPNLSSFQGYYFSSTMQLILSEFVPNGSLYDNLHLRIFPGTSSSYGNTDLNWHRRFQIALGTAKALSFLHNDCKPAILHLNVKSTNILLDERYEAKLSDYGLEKFLPVMDSFGLTKKFHNAVGYIAPELAQQSLRASEKCDVYSYGVVLLELVTGRKPVESPSENQVLILRDYVRDLLETGSASDCFDRRLREFEENELIQVMKLGLLCTSENPLKRPSMAEVVQVLESIRNGFGS
Protein: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) (A0A0C4DHF6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}. Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Protein O-mannosyl-transferase 2
- Protein O-mannosyltransferase 1
- Dystrophin, isoforms A/C/F/G/H
- Sarcoglycan alpha, isoform C
- Dystrobrevin, isoform F
- EG:4F1.1 protein
- IP02644p
- EGF domain-specific O-linked N-acetylglucosamine transferase
- Beta-sarcoglycan
- LP03706p
Sequence:
MRFQWFLSASASLSLFLLLDFVVWIHGERDFNVNDSQVPVIEPKDVPAYKQDPYVTELMSCQNTPSEIVLSLLLKKHDWSELTATKRAHVQAKLAKFFAIPKEFISLDSVSKRELRSMHKLAMRKGGKGNKNIETLNRRLGRASFMIGCGPSYFVMGEPIAKQIAHQMKDGTIGALTEENFGLWFIWRKELKSRSNRKRRQSEGSGADEDDYDYGDDDEEVAEPSTEVPPVTTHAHRHHHGALEVSEKIVSPESVSSSAVPLVPDVEEEIEESVSKLESVISKTIENTKNIKELPVLGEADDGEDEEEVELQQLGVPLAAEIVPDETTSAAATRATEMVKPVDLDEQEISVDSGAVPAIDVEASATPTPSMSARETQKPFSPYDATSSVSSSFSPVASIASGSEAGEDSTSVSTPHLSPANSPTVMPTELDRNGLATTSSSSSSSASPPPSSSVPTQATQPTTSASSFSSSSSTTTTSTTATVSTTTTASSTATTTTTTTTLSESPKPNTVLNELELSTQLPIDDFEGTATATQPTGTATATAIASTAAAAAATAAAATATATTANASATTAGESEFHIESTTHRTISSKEGGEPDAISSGNNSLANNELSTPATPTSSVATTTASTPESSSISSNFVSTDYMEPQPEENSPPIIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKANSWLQFNADKRELYGLPLDDTVSRWQYRLSATDSGNASVTETVEISVQQHRAVRTINHEISVFVRINEKPGHNIDWQLKLINAVARTLDDSTNSAVVVREIRQTPHDPHSATFVYFNETLPTSECPEKELKDIIARLDANRLSDLVQPQLGIKSITGQLIGSCQKDLTQVKPTQHMTKNVPPMPRNQVDRVNASLGQLLVYKVPADTFYDANDNQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDIGSEEYLLVAEDSGGLSAHDALVVVVSPAPKRDFGFFFKAYLSIKHERFNADLQRKFVERVAKLNGDPTTGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSCREKEVAMTRSVYLNSDLSLREAAKRALGPELNLTNFSVVPFSICHHTENIDTNQLDYIPSRPEEPTHKSSFGEDYMITFVWPIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQDEYEEKPEIGNKSPVILKDEKPPLLPPSYNTSNMNGDNDVDDYVPPPSVVVGGREVRGKSPATPSYRKPPPYVSP
Protein: YY1 transcription factor (A0A8I6A7Q7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEDDDEDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGSSSGGGRVKKGGGKKSGKKSYLGSGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKVVLSCRMYCTFNT
Protein: lysozyme (EC 3.2.1.17) (F2Z7L0)
Organism: Haemaphysalis longicornis (Bush tick)
Interaction partners:
Sequence:
MKRRLAVVILFALLSASSAKKFGRCELASILTRNGIPKNKIADWICLATAESSLNSRAINRNKNGSKDYGIFQINNGYWCSPGRHNICRVACSALQSDNIAPSIKCAKKIYQRHGFDAWYGWKNKCRGKNLSSYVKGCRY
Protein: Pre-mRNA-splicing factor syf1 homolog (Pre-mRNA-splicing factor fandango) (Protein faint sausage) (A1Z9G2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of its role in promoting embryo tracheal development is also due to specifically splicing bnl transcripts which results in the activation of the BNL-FGF pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:24755291}.
Interaction partners:
- RNA helicase aquarius
- Peptidyl-prolyl cis-trans isomerase E
- Pre-mRNA-processing factor 19
- Puff-specific protein Bx42
- Pleiotropic regulator 1
- Pre-mRNA-splicing factor RBM22
- Cell division cycle 5, isoform A
- Protein crooked neck
- RE31520p
- Pre-mRNA-splicing factor Syf2
Sequence:
MVTKTIKSLNLEINFEVEDVPYEEEILRNAYSVKHWLRYIDHKAKAPNNGVNMVYERALKELPGSYKIWHNYLRTRRKQVRGKIPTDPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHVFDRALRALPITQHGRIWPLYLQFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAAQQLAHIVDNEHFVSKHGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFDRARDIYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDIDVELRLSRFEYLMERRLLLLNSVLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAVGKLHTLWVEFAKFYEANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLMQRATAMPKRKIAYYDDTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQIIINYGMFLEEHNYFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLDQCPPEHAKYFYLLYAKLEEEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRTREIYEKAIESLPEQNMRHMCVKFAELETKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHGNEDTMREMLRIKRSVQATYNTQVNMMAAQFLSTNNGAAADAGAGAGPDAMRLLEEKARQAAAESKQKPIEKAASNIMFVRGETQGGAKDKKDTVVNPDEIDIGDSDEDDEEEDDDEENEMTNENQASAAVTKTDEEGLVMKKLRFEQKAIPAKVFGSLKPSNQGDSDGE
Protein: HLA-B associated transcript 8, rat orthologue (Q6MG72)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
- [histone H3]-lysine
- Histone deacetylase 1
- DNA
- DNA
- E3 ubiquitin-protein ligase UHRF1
- Chromobox 3)
- Lysine-specific histone demethylase
- Histone H3.3
- WIZ zinc finger
- Histone H3
Sequence:
MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHGSLGDTSHSEETLPKANPDSLEPTGPSSPASVTVTVGDEGADTPVGATPLIGEEPENLEGDGGRILLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPPPATTAGQEGQPKVHRARKTMSKPSNGQPPVPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLTSGSLSEDLGSAGGSGEVILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPVGTVAPAPPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPINT
Protein: Cu(2+) suppressing and bleomycin sensitive protein 1 (Q08977)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Chromo domain-containing protein 1
- Eukaryotic initiation factor 4F subunit p150
- Eukaryotic initiation factor 4F subunit p130
- mRNA-binding protein PUF3
- Pyridoxal phosphate homeostasis protein
Sequence:
MFASAGQQHPQIVPKEEESILNYLLEVRSSLAKLKQNRTQYLNSKDVQTTYQHVLTKVRELDDIRKNSHETPAKSAATLIHSTELHNRVDSVLDDVFQLLSLCFLTVGLKNSAPATYASLSTVESLLEHLNESNVFTHHDLSPIKERLEEISKIVEQKNSSPAYDEDGNDDRLREIDNERKKNKIEEDLLLRAKLKHCKDEYDILEGKLEEIDPSLSTVMEKLFRIRRGLLSLVASAKKTMSKSDINTNSLLQEQNDLQTNNESLTDDKHLVSQEYVHEKLSVLKNELSELESNRDDSGKFKSLESHQVAEKGQSVLNGLLDDCHDLVNDLSHQKNGGLTLDPYLQPIYEQLIDIKTTLENLMITRRWTLRETDLFSYQKKLNEIDNKRINGKFPTKSQDSKGQSILLYLLRRCYAIIYKLLESSEPVSEALQPIHNQLSTVRRCLLELKRMGGVNNERELYPYQMKLASLDNLRTEGIFYDSDGNIPEGQGILNALLAECFDILHELKVEAEEKAQNSTSSDGSDDDDNGESGIDSNSNDSEPESEYQQE
Protein: Diuretic hormone class 2 (DH(31)) (Diuretic peptide) (DP) (Rhopr-DH31) [Cleaved into: Diuretic hormone class 2(1-16) (Rhopr-DH31(1-16))] (P85826)
Organism: Rhodnius prolixus (Triatomid bug)
Function: Regulation of fluid secretion. Stimulates primary urine secretion by the Malpighian tubules. Increases the frequency of contraction in the heart and hindgut. Causes a dose-dependent stimulation of cAMP levels in the dorsal vessel and hindgut, but not in Malpighian tubules. Has synergistic effects on urine secretion by Malpighian tubules with serotonin.
Subcellular location: Perikaryon {ECO:0000269|PubMed:15626502}. Cell projection, dendrite {ECO:0000269|PubMed:15626502}. Cell projection, axon {ECO:0000269|PubMed:15626502}. Secreted {ECO:0000269|PubMed:15626502}.
Interaction partners:
Sequence:
GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP
Protein: PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12) (Q9H4Q4)
Organism: Homo sapiens (Human)
Function: Involved in the positive regulation of histone H3-K9 dimethylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:26005867}.
Interaction partners:
Sequence:
MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAAAHHLPAMVL
Protein: At3g10000 (Homeodomain-like superfamily protein) (Q700D8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- At5g63780
- Thioredoxin family protein
- B3 domain-containing protein REM2
- AT-hook motif nuclear-localized protein 11
- Ribonuclease J
- 14.7 kDa heat shock protein
- Trihelix transcription factor ASIL1
- NAC
- Scarecrow-like protein 28
- Protein BEARSKIN1
Sequence:
MEDHQNHPQYGIEQPSSQFSSDLFGFNLVSAPDQHHRLHFTDHEISLLPRGIQGLTVAGNNSNTITTIQSGGCVGGFSGFTDGGGTGRWPRQETLMLLEVRSRLDHKFKEANQKGPLWDEVSRIMSEEHGYTRSGKKCREKFENLYKYYKKTKEGKSGRRQDGKNYRFFRQLEAIYGESKDSVSCYNNTQFIMTNALHSNFRASNIHNIVPHHQNPLMTNTNTQSQSLSISNNFNSSSDLDLTSSSEGNETTKREGMHWKEKIKEFIGVHMERLIEKQDFWLEKLMKIVEDKEHQRMLREEEWRRIEAERIDKERSFWTKERERIEARDVAVINALQYLTGRALIRPDSSSPTERINGNGSDKMMADNEFADEGNKGKMDKKQMNKKRKEKWSSHGGNHPRTKENMMIYNNQETKINDFCRDDDQCHHEGYSPSNSKNAGTPSCSNAMAASTKCFPLLEGEGDQNLWEGYGLKQRKENNHQ
Protein: Expressed protein (Hydroxyproline-rich glycoprotein family protein) (O64751)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F16N3.9 protein
- PAR1 protein
- Embryo-specific protein 3
- Probable cysteine protease RD19C
- Sister chromatid cohesion 1 protein 1
- Protein NUCLEOLAR FACTOR 1
Sequence:
MASSSLISVALTLILIFHLMPETTVARRLTDQKPSDEVVTTTTDEANNLPFPPGLPFGGVPPLPSLFPPFVPSPFPGNIPRLPFPFPFPTSPPAPSLPGFPGFTFPPLPFLTPPPL
Protein: Moesin (Membrane-organizing extension spike protein) (P26038)
Organism: Homo sapiens (Human)
Function: Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11728332, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:7884872, ECO:0000269|PubMed:9298994}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26041}. Apical cell membrane {ECO:0000250|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26041}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:9298994}.
Interaction partners:
- Radixin
- Na
- Ezrin
- Sodium/hydrogen exchanger 1
- CD44 antigen
- Intercellular adhesion molecule 1
- Membrane cofactor protein
- Vascular cell adhesion protein 1
- Actin, cytoplasmic 1
- Leukosialin
Sequence:
MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM
Protein: Neuropeptide Y receptor type 1 (NPY1-R) (FC5) (P21555)
Organism: Rattus norvegicus (Rat)
Function: Receptor for neuropeptide Y and peptide YY.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-neuropeptide Y
- Peptide YY
- Pancreatic polypeptide prohormone
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Appetite-regulating hormone
- Somatostatin
- Cell cycle control protein 50A
- Carboxypeptidase Z
Sequence:
MNSTLFSRVENYSVHYNVSENSPFLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKIRDSKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMNDNEKI
Protein: Regulatory protein RecX (Protein OraA) (P33596)
Organism: Escherichia coli (strain K12)
Function: Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Protein RecA
- DNA repair protein RadA
- DNA repair protein RecO
- LexA repressor
- Protein UmuD
- DNA damage-inducible protein I
- DNA repair protein RecN
- Recombination protein RecR
- DNA replication and repair protein RecF
- ATP-dependent DNA helicase RecG
Sequence:
MTESTSRRPAYARLLDRAVRILAVRDHSEQELRRKLAAPIMGKNGPEEIDATAEDYERVIAWCHEHGYLDDSRFVARFIASRSRKGYGPARIRQELNQKGISREATEKAMRECDIDWCALARDQATRKYGEPLPTVFSEKVKIQRFLLYRGYLMEDIQEIWRNFAD
Protein: Uncharacterized protein (Q555G2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSSPYPSEKKNDAQVLKEQVKGTFDQYMPISLQTKEKSKRVKAQITDLKDENSKLLKETKKFQNRLIEESSLLYFLQKEAHLLKKIVNNKNPEIKTLNQTIYDQHESIKKLKEEVEKEQNNVTMQIELKELLKQSENKLLLELTSVKDTLLIESQSHLQVKGILKETEDKLEQEIKINKEKLEKLDKEINEHKDSINQLQERLESTQDQLSKSQQENQEKSKDIEELKSQLELNLQEIERLKIEINSEKQKFENLQDTYNQLIEKNKEIIKSLEEEVKIKDELQIALNELKEKNQEITEIKEKEEIKNQELTKENQELTLELTQSQQQNKDNESKINQHQETIEQLEQEKQTLQNELNKFEQDKEILEANIKTLTIELDNKVMEVDELSQLRSNLNLEIECVRKSHIKEMEELTLQIQQLQQHLEQDKNDIQQREQEISTLQQENKETSLKIQSLTIEITNRDQSIQEKELKIQQLEEQLEQTKEELTSITRQLQKVEVQRESLEHENESIREMVSQSSIKGLDELIASQKETYQKDVQTLNFTLLEKNNTIQDKDKEIQQLNETISKLQSEIQDEKDKLEQQVKQREQDLLNFQEEKERINRKNVEDQVDSEQVTEKVVGDLKHIIDNISSEKELIQKEANNLAQRLSNEIDKSKDMEKKVKDLGKEFESMLATNDNLAKELEESQQQLSKSNQLLNQHIADGANKVSDHDHEQLLKELNDLKSKNKEIDDRIQQERQQWHSNRWEIVAELEQEKSKYKKSQDLLLDEKRRMGVVGKTVSKLLEDNEKRSFDSMTPESFYAMLEAAKKELDEGLQHRKQYYDDEDLNGQLLMEREARRLAESQVEHFAVLLEKSKVEIQKYKEIINNGGANNNNNNKSGFFSNLMNNTSNNSFIKRTFTGSTFGNNNNNNNNQK
Protein: Glycine hydroxymethyltransferase (Serine methylase) (G3V241)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMG
Protein: Junctional adhesion molecule A (Junctional adhesion molecule 1) (Q66I72)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Tight junction protein 1a
- Afadin, adherens junction formation factor a.
- Tight junction protein 2b
- Tight junction protein 2a
- Junctional adhesion molecule 3a
- Par-3 family cell polarity regulator.
- Par-3 family cell polarity regulator alpha, b.
- Occludin
- Junctional adhesion molecule 3B
- Integrin beta
Sequence:
MLTFAFVCFSLFVTGIHGFQVTVTSPVKVKENEGVDLQCSYTSDFGATPRVEWKFKDLKGSQTLVYFDGKPTGQYTGRVTMYDKGLRFNKVTRADTGDYDCEVSGSGGYGENTIKLTVLVPPAKPVSRIPSSVTTSSNVRLTCFDPVGSPPSTYKWYKDNTPLPEDPTKFPAFKNLTYKMNVFNGNLEFPSVSKMDTGSYFCEASNGEGVPQRGDEVKMEVRDLNVGGIVAGVIVALLAVGLLLFGLWYASKKGYLPKLSETKQKPQAVYTQPQTDDVDEANGFRQKSSFVV
Protein: Type I interferon 2 (Q70G08)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MCTMQSWTCLFLILCSMQSVCHCCDWIQHHFGHLSAEYLSQLEQMGGDITKQNAPVLFPTSLYRHIYDAEFEDKVRFLNETIYQIIKLFDGNRNRNRKSVTWDKKNLDDFLNILDRQFENLSSCVSPVVKPEKRLKRYFRNLNRKVLRKMNYSAEAWELIRKETKRHLQRLDILVGQMY