wanglab/gogpt-training-data huggingface dataset:
Protein: 2-Cys peroxiredoxin BAS1, chloroplastic (2-Cys Prx A) (2-Cys peroxiredoxin A) (EC 1.11.1.24) (Thiol-specific antioxidant protein A) (Thioredoxin-dependent peroxiredoxin BAS1) (Q96291)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May be an antioxidant enzyme particularly in the developing shoot and photosynthesizing leaf.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:9263459}.
Interaction partners:
- NADPH-dependent thioredoxin reductase 3
- Sulfiredoxin, chloroplastic/mitochondrial
- Peroxiredoxin-2E, chloroplastic
- Thioredoxin F1, chloroplastic
- Thioredoxin-like protein CDSP32, chloroplastic
- Thioredoxin M4, chloroplastic
- Peptidyl-prolyl cis-trans isomerase CYP20-3, chloroplastic
- Thioredoxin-like 2-1, chloroplastic
- L-ascorbate peroxidase T, chloroplastic
- Peroxiredoxin-2C
Sequence:
MASVASSTTLISSPSSRVFPAKSSLSSPSVSFLRTLSSPSASASLRSGFARRSSLSSTSRRSFAVKAQADDLPLVGNKAPDFEAEAVFDQEFIKVKLSDYIGKKYVILFFYPLDFTFVCPTEITAFSDRHSEFEKLNTEVLGVSVDSVFSHLAWVQTDRKSGGLGDLNYPLISDVTKSISKSFGVLIHDQGIALRGLFIIDKEGVIQHSTINNLGIGRSVDETMRTLQALQYIQENPDEVCPAGWKPGEKSMKPDPKLSKEYFSAI
Protein: Butyrophilin-like 8 (M0RD77)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGIYCKPSVLFQDSYLLVLTQLLCWVTTKGFRVFGPSDPVVAAPGREAILPCSVSPAMSVENMEELRWFRTRFSQAVFVYRDQEEQKEEQMIEYSWRTSLVKDKFHEGKAAVRIQNVQESDSGIYVCHFKQGHFHEEAILELKVAAMGSVPEVYIKGPEDGGVCVVCMTSGWYPEPQVHWRDSRGEILPASSETLHEDAEGLITTETSLVLRDSSVRNVTCSTFNPVLGQEKAMAMVIPEPFFPQASPWKTAFLVILTMMGLLVLGTISLFGWERFVRLKLQKEQIHIHCEKDELQTEKEDALRTASALREEL
Protein: Cell adhesion molecule-related/down-regulated by oncogenes (Q4KMG0)
Organism: Homo sapiens (Human)
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Sonic hedgehog protein
- Indian hedgehog protein
- Desert hedgehog protein
- Protein patched homolog 1
- Growth arrest-specific protein 1
- Protein patched homolog 2
- Brother of CDO
- Low-density lipoprotein receptor-related protein 2
- Cadherin-2
- Cadherin-15
Sequence:
MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPRET
Protein: RuvB-like helicase (EC 3.6.4.12) (Q9M2X5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RuvB-like protein 1
- Actin-related protein 4
- SWR1-complex protein 4
- SWR1 complex subunit 2
- SWR1 complex subunit 6
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Actin-related protein 5
- Protein EIN6 ENHANCER
- Actin-related protein 9
- Chromatin-remodeling ATPase INO80
Sequence:
MAELRLSETRDLTRIERIGAHSHIRGLGLDSVLEPRAVSEGMVGQIKARKAAGVTLELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGQETPFTMIAGSEIFSLEMSKTEALTQAFRKAIGVRIKEETDVIEGEVVTISIDRPASSGGSVKKTGKITMKTTDMESNFDLGWKLIEPLDKEKVQSGDVIVLDRFCGKITKLGRSFTRSRDFDVMGSKTKFVQCPEGELEKRKEVLHSVTLHEIDVINSRTQGYLALFTGDTGEIRSETREQSDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENDMSPILVVATNRGMTTIRGTNQISAHGIPIDFLDRLLIITTQPYTQDEIRNILEIRCQEEDVEMNEEAKQLLTLIGCNTSLRYAIHLINAAALACLKRKGKVVEIQDIERVYRLFLDTKRSMQYLVEHESEYLFSVPIKNTQEATAGEETEHEAMEV
Protein: Myosin IG (A0A3B3IU30)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEDEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAHCQG
Protein: Acyl-CoA N-acyltransferases (NAT) superfamily protein (At2g32020) (Putative alanine acetyl transferase) (Q9SKZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable inactive poly [ADP-ribose] polymerase SRO2
- At2g31940/F20M17.2
- External alternative NAD
- External alternative NAD
Sequence:
MEMDSEETNPIMSSSPPGRISLRPMTLSDVDDYMVWATDPKVARFCTWEPCTSRDEAIKYITDRVLTHPWLRAICLEDDRPIGYILIMAVDNIRKEIGYVLARKYWGKGFATEAVRLVTAEVFEEFPEIERLEALVDVDNVGSQRVLEKVGFTREGVMRKFICIKGSVRDTVMFSFLSTDTLK
Protein: Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) (O00629)
Organism: Homo sapiens (Human)
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:28760339, ECO:0000305|PubMed:29042532}. Nucleus {ECO:0000305|PubMed:28760339, ECO:0000305|PubMed:29042532}.
Interaction partners:
- Transcription factor p65
- Importin subunit beta-1
- Regulator of chromosome condensation
- Nuclear factor NF-kappa-B p105 subunit
- Exportin-2
- Importin subunit alpha-4
- Importin subunit alpha-5
- Ran-binding protein 3
- Transcription factor SOX-2
- GTP-binding nuclear protein Ran
Sequence:
MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF
Protein: Protein At-4/1 (Tomato spotted wilt virus movement protein-interacting protein 4/1) (At-4/1) (Q1PE49)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in intra- and inter-cellular trafficking through plasmodesmata (PD).
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16903353}. Cell junction, plasmodesma {ECO:0000269|PubMed:16903353}. Note=Accumulates intracellularly in a polarized fashion, into punctate spots at the cell periphery. Located at both orifices of the plasmodesmatal pore of adjacent cells. Can move through plasmodesmata.
Interaction partners:
- PRA1 family protein D
- Plasmodesmata-located protein 4
- Plasmodesmata-located protein 3
- Plasmodesmata-located protein 2
- Remorin
- Ubiquitin-like superfamily protein
Sequence:
MAATSDEQMNLLLSSFDQIYEDFKIGLNEINVYRSKSNVESSRREVLEISNKNLKEENERLKKLYTESLNNFADQLEHRTKCHSLKEELKRVNDENKSKEHEHRNALESLRQKHVTKVEELEYKIRSLLVEKATNDMVIDRLRQDLTANKSHIQAMSKKLDRVVTEVECKYELEIQDLKDCLLMEQAEKNDISNKLQSLQKELLISRTSIAEKQRDTTSNRQVETLKQKLMKLRKENEILKRKLSSS
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (B1AKC9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMME
Protein: Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5) (Q9ESS0)
Organism: Mus musculus (Mouse)
Function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y6W6}. Nucleus {ECO:0000250|UniProtKB:Q9Y6W6}.
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 11
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
Sequence:
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSASPGSGSHAPVLATAVVTLKAANLTYMPSSSGSARSLNCGCSSTSCCTVATYDKDHQAQTQAIAAGTATTAIGTSTTCPANQMVNNNENTGSVLSPSGGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVTPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHGNLCDNSLQLQECREVGGGASAASSMLPQSVPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGMETVV
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) (Q91UZ1)
Organism: Mus musculus (Mouse)
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein G
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Guanine nucleotide-binding protein subunit alpha-14
- Guanine nucleotide-binding protein G
- Inositol polyphosphate-5-phosphatase A.
- Guanine nucleotide-binding protein G
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
Sequence:
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSMMEAGESAAPASILEDDNEEEIESADQEEEAHPEYKFGNELSADDYSHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAALGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
Protein: Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (mNAT) (System N amino acid transporter 1) (Q9DCP2)
Organism: Mus musculus (Mouse)
Function: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine. The transport activity is specific for L-glutamine, L-histidine and L-asparagine. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions. Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18689705, ECO:0000269|PubMed:30017230, ECO:0000269|PubMed:32046769}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10716701}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein (PubMed:10716701). Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells (PubMed:32046769). In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling (PubMed:30017230). Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (PubMed:21364602). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10716701, ECO:0000269|PubMed:21364602, ECO:0000269|PubMed:30017230, ECO:0000269|PubMed:32046769}.
Interaction partners:
- Sodium-coupled neutral amino acid transporter 5
- Excitatory amino acid transporter 1
Sequence:
MEIPRQTEMVELVPNGKHLEGLLPVGVPTTDTQRTEDTQHCGEGKGFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEKPASVWYMDGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFQVPCPLAHNLANATGNFSHMVVAEEKAQLQGEPDTAAEAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMYFLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAIQQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAIFYFRIMPTDKEPARSTPKILALCFAAVGFLLMTMSLSFIIIDWVSGTSQHGGNH
Protein: G2/mitotic-specific cyclin-B2 (P13351)
Organism: Xenopus laevis (African clawed frog)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Interaction partners:
Sequence:
MATRRAAIPREADNILGGAMRSKVQMNSRRAALGEIGNKVTVRGKPPAVKQSSNAVAKPSKMAATKVANVKTKHVPVKPVVAEAAPKVPSPVPMDVSLKEEELCQAFSDALTSVEDIDADDGGNPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFDLGRPLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLIMKHMAKNITKVNQNLTKHVAVRNKYASSKLMKISTLPQLMAPLITELAASLS
Protein: Saposin B-type domain-containing protein (Q86FL8)
Organism: Caenorhabditis elegans
Interaction partners:
- Saposin B-type domain-containing protein
- Antitoxin
- Saposin B-type domain-containing protein
- Saposin B-type domain-containing protein
- Chitin-binding type-2 domain-containing protein
- KIF-binding protein
- TCTP domain-containing protein
Sequence:
MKTLLVLAVLVAVASGLAIPENRSALSCQMCELVVKKYEGSADKDANVIKKDFDAECKKLFHTIPFGTRECDHYVNSKVDPIIHELEGGTAPKDVCTKLNECP
Protein: Alphabet, isoform F (EC 3.1.3.16) (A0A0B4K7Q3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
Sequence:
MGGFLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRIDEVMRELPEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFPGAPKPTEEAIEAEHRLEKQIEKITRERELAEWANCQCKNKKQKAIQI
Protein: Permease IIC component (Q72XQ0)
Organism: Bacillus cereus (strain ATCC 10987 / NRS 248)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MIRFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGE
Protein: Large ribosomal subunit protein uL13 (50S ribosomal protein L13) (P0AA10)
Organism: Escherichia coli (strain K12)
Function: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Interaction partners:
- Small ribosomal subunit protein bS18
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein bL20
- Elongation factor G
- Small ribosomal subunit protein bS20
- Large ribosomal subunit protein uL15
- Alternative ribosome-rescue factor A
- Small ribosomal subunit protein uS17
Sequence:
MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI
Protein: Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) (Q69Z37)
Organism: Mus musculus (Mouse)
Function: May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.
Subcellular location: Early endosome {ECO:0000269|PubMed:24029230}. Mitochondrion {ECO:0000250|UniProtKB:Q8IVG5}.
Interaction partners:
- Interferon-induced protein 44
- Signal transducer and activator of transcription 1
- Epithelial-stromal interaction protein 1
- Protein mono-ADP-ribosyltransferase PARP9
- Interferon-induced protein with tetratricopeptide repeats 3
- HEPACAM family member 2
- Antiviral innate immune response receptor RIG-I
- Interferon-induced protein with tetratricopeptide repeats 2
- Interferon-induced helicase C domain-containing protein 1
Sequence:
MSGQVTQPKLIKDWTKEHVRKWVTEDLNIVEKYAQILFKEEVTGMVLQELTEEDLREMGLPRGPALLIKRMYNKLISSPESHNQDSRELNDKKLSTKEQQTKTKNEEENSVSSNSDHGLRETGQNEEQEPSLTKENMLGDVVTKDMEDNKPKPEQMSCTPYPFDSFCDVKQYIEHSILRVAETGPLNLIDPIHEFKAFTNTKKATEEDIKMKFSNETFRFAAACMNSRTNGTIHFGVKDKPHGEIVGVQVTSKDIFVNHFNTMITKYFEDSEISEARACIREPRFVEVLLQNNTQSNRFVIEVDVIPRHSICQEKYFYIMMQSSTGKTWKQSKDTSLFVREGASSKNILGNPNQRDREFKKFLEDLKMWTASRKAAEEELRMVTKKESEGLKLSKLLTRHQGSLDESYYDWYILVTNTCAPTQLEHLEFIKEMKLFAVLDFDPYSHIKGVVKAYRESRIANLHLPSHYEEKTTIAEKISTLKLYEQPSWIFCNGRVDLSCQPLEPHLWQRDRASGVRRLISFLTDENIIVKGKVLVVFLLLSPIENQKDPLIETFCAFYQVFNGMDNMLCICVNSAIYQQWSDLLQVRLEIKDDLAKHSISTLNIELVNNTILKLKSVIQSSRRFLPSCGSSSVILEKMDEDIMSALEILCENECKDTDIEKDESQFLEFKKSREEHFYRGGRVSWWNFYFSSENYSSAFVKRDSFEELTTLIQQCADSPKPVFVKVINLYHHPGCGGTTLAMHVLWDLKQKFRCAVLKNKATDFVEIGEQVSKLMSYKATSHEDFIPVLLLVDDFEEQENAYILQNAINAFIAEKGLRYEKTLVIILNCMRSQNPDESAKLANSISLKYQLSPKEQRAFEAKLQEIEKEHKNCENFYSFMILKGNFDTTYIKNVVKNTLKDLDAKSRRAQLISYLALLNSYVTDSTISVSQCEIFLGITYTKKYGKPETVEKNMGTYSTLLIRTEVSDYGRYTGIRIIHPLIATHCLKELEMSYRMDKCQIALNMLEENVLYDSGLGRDKFKYDVQTLLLTRQRKEHGAETDTLFSPLIEELQNEETEKVLIAGSDRFPQNAFICQALARHFYIKEKNFSTALVWANLAKRKAPKNSYISDTLGQVYKSELNSGWEVAEKASKAFKESQNQSDSKDYGTEAWSPQNSQRRYDTFNTAGFFGEIEVGLDTIQLLQLTPLFHKENEISKESMAEFLSGKGTILSDPKGEYCVVLSKFTSLLQNLHSDLERCFHFFGDYMGFLKPRNTPKELTELLLSKKVSRCFKKYVELFCHLDTNLVQGKEDLLLQKENCRKRIQAWRADTFSGLLEYLNPNHKEANNIENIVGNYTFLLQDILNKQLSKVLTKDIQNFILANIILSCLKPSSKYILPFSTLKKKLREVLQIVGLTHSYPDPYFLACLLFWPENKELDEDSTLIEKYVSSLNRSFRRQYKHMCRSRQPSTLFYLGQKKGLNSLVHKAEIERYFSEVQDSNSFWHSGVVWEKREVKDLLRLLDGQAEGKLISLEYGTEAKIKIPVTSVYSAPLRSGRNIERVSFYLGFSIEGPLAYGIKVI
Protein: Prosalusin (Torsin family 2 member A) (Torsin-2A) [Cleaved into: Salusin-beta] (P0C7W3)
Organism: Mus musculus (Mouse)
Function: Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusin may also be a potent hypotensive peptide (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MAVARHGYRPWGSILGLLGLALAAAAAWDVASLRCTFGSFCECDFWPDLPGLECDLAQHLAGQHLAKALVVKSLKAFVQDPAPSKPLVLSLHGWTGTGKSYVSSLLAQHLFRDGLRSPHVHHFSPIIHFPHPSRTEQYKKELKSWVQGNLTACGRSLFLFDEMDKLPPGLMEVLQPFLGPSWVVYGTNYRKAIFIFIRWLLAVWHHGGAPAGRCGALPPAPAASRAPLRTQ
Protein: Sorcin (A0A8I5ZTT7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MCGGAPGGPVFPGHTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFSEFRELWTVLSGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV