wanglab/gogpt-training-data huggingface dataset:
Protein: Polyamine aminopropyltransferase (Putrescine aminopropyltransferase) (PAPT) (Spermidine synthase) (SPDS) (SPDSY) (EC 2.5.1.16) (P9WGE5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00198}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00198}.
Interaction partners:
- S-methyl-5'-thioadenosine phosphorylase
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- UPF0719 transmembrane protein Rv2600
- Uncharacterized protein Rv2598
- Uncharacterized protein Rv2597
- N
- Probable amino acid decarboxylase
- Arginine deiminase
Sequence:
MTSTRQAGEATEASVRWRAVLLAAVAACAACGLVYELALLTLAASLNGGGIVATSLIVAGYIAALGAGALLIKPLLAHAAIAFIAVEAVLGIIGGLSAAALYAAFAFLDELDGSTLVLAVGTALIGGLVGAEVPLLMTLLQRGRVAGAADAGRTLANLNAADYLGALVGGLAWPFLLLPQLGMIRGAAVTGIVNLAAAGVVSIFLLRHVVSGRQLVTALCALAAALGLIATLLVHSHDIETTGRQQLYADPIIAYRHSAYQEIVVTRRGDDLRLYLDGGLQFCTRDEYRYTESLVYPAVSDGARSVLVLGGGDGLAARELLRQPGIEQIVQVELDPAVIELARTTLRDVNAGSLDNPRVHVVIDDAMSWLRGAAVPPAGFDAVIVDLRDPDTPVLGRLYSTEFYALAARALAPGGLMVVQAGSPYSTPTAFWRIISTIRSAGYAVTPYHVHVPTFGDWGFALARLTDIAPTPAVPSTAPALRFLDQQVLEAATVFSGDIRPRTLDPSTLDNPHIVEDMRHGWD
Protein: FI18194p1 (Myosin binding subunit, isoform I) (Q8IQN4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSLDARNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFANATTKNSLSELEKRERRAMERKLSELEEELKQLDAYKSDNHRLKEENAALIRVISKLSK
Protein: Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) (P35348)
Organism: Homo sapiens (Human)
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:24567387}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:24567387}. Membrane, caveola {ECO:0000269|PubMed:24567387}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-12
- Alpha-1B adrenergic receptor
- Alpha-1D adrenergic receptor
- Rho guanine nucleotide exchange factor 12
- C-X-C chemokine receptor type 4
- Angiotensinogen
- Guanine nucleotide-binding protein G
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Protein: Putative transposase for insertion sequence element IS986/IS6110 (ORFB) (P9WKH9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the transposition of the insertion sequence.
Interaction partners:
- Insertion element IS6110 uncharacterized 12.0 kDa protein
Sequence:
MPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q7KTC1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
Sequence:
MADDTSSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQVTSYFFCSLTLALGCIFCSKVLHETLLSYVFRWPMELFDTTPLGRVVNRFSKDVDTIDNVLPMLWRMVISQAFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV
Protein: Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cytoplasmic tRNA adenylyltransferase 1) (Q99J10)
Organism: Mus musculus (Mouse)
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03053}.
Interaction partners:
- Cytoplasmic tRNA 2-thiolation protein 2
- Adenylyltransferase and sulfurtransferase MOCS3
- Ubiquitin-related modifier 1
- Elongator complex protein 3
- Elongator complex protein 4
- Cysteine desulfurase
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- tRNA
- WD repeat-containing protein 74
- Elongator complex protein 5
Sequence:
MPAPTCFSCHKTRAALRRPRSGQALCGSCFCAAFEAEVLHTVLAGHLLPPGAVVAVGASGGKDSTVLAHVLRELAPRLGITLHLVAVDEGIGGYRDAALEAVRSQAARWELPLTIVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARLVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGVLGSTGEGCALPRCRPLQFASQKEVVLYAHFRHLRYFSEECVYAPEAFRGHARDLLKLLEAARPSAVLDLVHSAERLALAPAAKPPPPGTCSRCGALASHKLCQACALLDGLNRGLPRLAIGKGRRVLQVEPPQPGNPSLVTSDPVAPAGPCTCKQPKDKANPCGNGGDRAGATCVSQCDLSPGNGEDRAGATCVSQRDLSLGNGGDRAGATCVSQCDLSPVAE
Protein: Glycerophosphodiester phosphodiesterase GDPDL1 (EC 3.1.4.46) (Glycerophosphodiester phosphodiesterase-like 1) (ATGDPDL1) (Glycerophosphodiesterase-like 3) (Protein SHV3-LIKE 2) (Q7Y208)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine in vitro.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Glycerophosphodiester phosphodiesterase GDPD4
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- Fasciclin-like arabinogalactan protein 7
- Protein NRT1/ PTR FAMILY 2.5
Sequence:
MNSRPSNPTKLVIRSSTLLFCGVVLIHLFAAQIDAQRSTSRWQTLNGDAPLVIARGGFSGLYPDSSIAAYQLATLTSVADVVLWCDLQLTKDGLGICFPDLNLANASTIDRVYPNREKSYSVNGVTTKGWFPNDFSLTELQNFLLIRGILSRTDRFDGNGYLISTIEDVVTTLNREGFWLNVQHDAFYEQQNLSMSSFLLSVSRTVSIDFISSPEVNFFKKITGSFGRNGPTFVFQFLGKEDFEPTTNRTYGSILSNLTFVKTFASGILVPKSYILPLDDEQYLVPHTSLVQDAHKAGLQVYVSGFANDVDIAYNYSSDPVSEYLSFVDNGDFSVDGVLSDFPITASAAVDCFSHIGRNATKQVDFLVISKDGASGDYPGCTDLAYEKAIKDGADVIDCSVQMSSDGVPFCLRSIDLRNSIAALQNTFSNRSTSVPEISSVPGIFTFSLTWPEIQSLTPAISNPFRVYRIFRNPREKNSGKLISLSQFLDLAKTYTSLSGVLISVENAAYLREKQGLDVVQAVLDTLTEAGYSNGTTTTKVMIQSTNSSVLVDFKKQSKYETVYKIEETIGNIRDSAIEDIKKFANAVVINKDSVFPNSDSFLTGQTNVVERLQKSQLPVYVELFRNEFVSQAYDFFSDATVEINAYIYGAGINGTITEFPFTAARYKRNRCLGREEVPPYMLPVNPGGLLNVMSPLSLPPAQAPNQDFIEADVTEPPLSPVIAKAPTSTPGTPSTIAQAPSGQTRLKLSLLLSVFFLSLLLL
Protein: UPF0598 protein CG30010 (Q8MKL1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLFLDDAKMKNFTSCFKEKDFLKFFFNRLRLNKTSRYESEFPYISLCGRERNFIRCDDTPVVFTEQLRKDDTEVLSYAHAGQVLTLPYEPHKLYMDPRNGRVYHPAAPQVGGIGLVRSKLAIELSQHFEFLAGEASPTHFQWNGERLELQNEWVNNTQRFPMNEDCK
Protein: Kinesin-like protein (Q386I3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MERQLRELLEQGGLSHTIQGFVDGGVLTLQQLKQLTMQDYQSVGVIVMTDRRKLFELIQYMKREQANPPSVLNTSDAPRVPEHTPQAVTGARNTTPNCRNATPSSAQRKAENENARMNESRQLSGAGGRRDPLHVIDDMELSAMKMTPNSRPLSRVARASPTAATRKPGESGTTKRKASRITVVVRKRPLSTSEINDGLYDILATDPDNLQAIALLEPKQKVDLTKYIEKHRFTYDLVLDDKYSNRDVYEKACKPLIETVFEGGCATCFAYGQTGSGKTYTMLGKGDQEGIYLMAARDLYARLESGMSIMVSFFEIYGGKLFDLLNEREKLACREDSRGVINVCGLTEHRVEDTGHLMRVIDYGNSIRAAGSTGMNADSSRSHAILHITVLNSKNRFFGRFTFIDLAGSERGADTLDSDRTTRLEGAEINKSLLALKECIRALDQNHRHIPFRGSKLTAVLRDCFTGNSRTVMIGNVSPASGSCEHTLNTLRYADRVKELKKDKSSRIAAEEIMIGQMPSEEIETLGLSSNFAQRRAREKKAGTRSSSHLSQREPGTPNAKSHSSYGSGYRLKGQHSRVSMSCKEEDYPNFSDSIRSGKVPSSGGTKSFNRVTPKHSRVGSEISIRDASPYEMTSFASGDSLDEEEDNTILGHRRHIDAMMELLKQEMTELNGVEMPGASIEVYCKNVESILNRQAKSISSVRNMIRQLLNRLESRQRR
Protein: MICOS complex subunit Mic60 (Mitochondrial inner membrane protein) (Mitofilin) (Q3KR86)
Organism: Rattus norvegicus (Rat)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q16891}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000250|UniProtKB:Q16891}.
Interaction partners:
- MICOS complex subunit Mic25
- Coiled-coil-helix-coiled-coil-helix domain containing 3
- MICOS complex subunit Mic10
- MICOS complex subunit
- Sorting and assembly machinery component 50 homolog
- MICOS complex subunit
- Metaxin-2
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- DnaJ
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Sequence:
MLRACQLSGVTVAAQSCLCGKFVLRPLRPCRRYSTSSSSGVTAGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPLPKKPIQSGPLKISSVSEVMTDSELPMAQTQETNGDTPASAAGDPAPEVEHEDTINTECPNTDEGTSTFVTAALAKSLEDALNQTATVTRQTITAQNAAVQAVKAHSSTLKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGATPYITAAEEKLHSMIVDLDSVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGTLSTDDLNALIAHAHRRIDQLNRELAQQKATEKQHIELALERQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKFEFEQDLSEKLSEQELEFHRRSQEQMDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVSCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLAGRVAMIDETKNSLYQ
Protein: Uncharacterized MFS-type transporter C947.06c (O43081)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Copper-binding regulatory protein cuf2
- Putative fatty acid elongase 1
Sequence:
MKENDHLNSVSSSEIEKCDEDVEEELYSYPDSDFLVTFNGEDDPEKPLNWPVSIKLLNTALYGLTTFAAQFNSTTMSPTTSHLVNAYPIGHEVAVLPTCLYILGIAFGPMIFAPFSEVNGRKIGVLVPFFLSILFTIGTASSDSVAAIMCTRFFAGLFAGAPVVSSGGVMADLWCPAQRGTALIFYAFFVVSGADFGPIISSLVTEHSDTAWRWPLWTIVIIECFILTLDVFLIKETFGPVILATKAKNLRLTTKNWGLHAAHDEYRLDFKEFVTLHLVRPFAMLATPIVFFIAMFASYVYGILYLVLTTIPYTFGMTKNWQGTISTLPMIAMFTGVVIGGSFNIMWNQRYAKLITANGGKPLPEQRLPLMMAVGWLMPAGIFVFAWTNSPNIHWIAPFIGISMMGAGFFVIFQGCLNYLVDTFTKFAASAIAANTFTRSIFAGTFPLFSEIMFKKLGVHWGGSLVGFIALGMIPIPFIFYMMGDKLRRKNRFIKLIT
Protein: AT5g57120/MUL3_6 (Nucleolar/coiled-body phosphoprotein) (Q9LU74)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT5g05210/K2A11_8
- Nucleolar protein 56
- Guanine nucleotide-binding protein-like NSN1
- Nucleolar protein 56
- Uncharacterized protein
- Nucleic acid-binding protein
- Centromere protein O
- Serine/Threonine-kinase
- Protein BIG GRAIN 1-like B
- At5g10060
Sequence:
MGNESKTSALESEQKALLLRSVAQYLERCGFSKCFKKLLSEAEIEKKELNTSLPDLEEIFSEFLNKRDHEAAANGNTEANVVEAVENVKKDKKKKKNKETKVEVTEEEKVKETDAVIEDGVKEKKKKKETKVKVTEEEKVKETDAVIEDGVKEKKKKKSKSKSVEADDDKEKVSKKRKRSEPEETKEETEDDDEESKRRKKEENVVENDEGVQETPVKETETKENGNAEKSETKSTNQKSGKGLSNSKEPKKPFQRVNVDEIVYTENSNSYYSKGGAEIGYGLKAQEVLGQVRGRDFRHEKTKKKRGSYRGGLIDQESHSTKFNNSDDEE
Protein: dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) (Pyruvate dehydrogenase complex component E2) (Q9VM14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit alpha
- Dihydrolipoyl dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- [Pyruvate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit alpha
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha
- 2-oxoglutarate dehydrogenase, mitochondrial
Sequence:
MLRSLATTRNELGALRSVLLRSNNATYVRRSTGNVVVRALSSQLINSRKLQSIRSKLNTSQSPVTWSYNFARAYANLPEHIRVPLPALSPTMERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILIQGGTKDVPVGQLLCIIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAPAAAAPPPAPAAAPAAAGTGRVYASPMAKRLAEAQQLRLQGKGSGVHGSIKSGDLAGQKAAAKPAAAAPAKAPRAAGARYEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDKLLKFRAKVNKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAWMDTVIRKYDDVDVSVAVSTDKGLITPIVFNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQFAAVINPPQSCILAIGTTTKQLVADPDSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL
Protein: Ac2-248 (Serpin family C member 1) (Q7TPI9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MVHMLVNASTREVEIEDRSLAGQPSYPNEPAPEQPSITSIPEPSRVLTQANAVRMLVTRRCTILGPLGVRNYQEDISLSSEKAPCIRLQSLEDLVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSNLVSANRLFGDKSLTFNESYQDVSEIVYGAKLQPLDFKENPEQSRVTINNWVANKTEGRIKDVIPQGAIDELTALVLVNTIYFKGLWKSKFSPENTRKEPFHKVDGQSCLVPMMYQEGKFKYRRVGEGTQVLEMPFKGDDITMVLILPKPEKSLAKVEQELTPELLQEWLDELSEVMLVVHVPRFRIEDSFSLKEQLQDMGLVDLFSPEKSQLPERFGSGMTVMTAQWRVLAEHTPDSQAPHPVLKGQGERDLSKAQVAQQTGQMGMSGSGVTKAQCSSKTEEELSQGKVETPKDLKMSNSLISISDQRTAGFRHRCPHGTGEEKARTLRTSSLLSEPTVAPQLLTKGGNTSFSKAISICFKMRLQAELNPQVVATHSSWCDCPLKGKEDCQSIGLSFACLALFLCNHPRSTNWRPRDSREVLNEYNMPGHGLLNPVLTQALGICFAESYTQAQWFTRQPLAVLS
Protein: 14-3-3-like protein, putative (Q384Y3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein DPCD
- Small GTPase, putative
- Uncharacterized protein
- 1-phosphatidylinositol 4-kinase
- Eukaryotic translation initiation factor 4E, putative
- Prohibitin
- SH3 domain protein, conserved
- Rab GDP dissociation inhibitor
- uracil phosphoribosyltransferase
Sequence:
MAGFQIPEKREQLTVMARIAEQCERYDEILVCMKRVVKLNPVLSSEERNLLSVAYKNVIGARRACWRSISALEQKEDLKKEKNVTLIKAFKRQIEKELSDICIDILELIEKHLLPNAETDETKVYYLKMKGDYHRYYAEIETNTEEQKDKALEAYTQAMQYNASLKPTSPIRLGLALNFSVFYYEILKSPDRGCQLAREAFEEALSDPDVLDEEQHKEAALIMQLLRDNLALWTEDAHPEGRDDGTAMEELE
Protein: ITPR interacting domain containing 2 (E9PHV5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLEEQLRAVRMPSPFRSSALMVTELMQEQSYLKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH
Protein: Protein TILLER ANGLE CONTROL 1 (ZmTAC1) (Leaf angle-associated protein) (C4IZI7)
Organism: Zea mays (Maize)
Function: Involved in the regulation of leaf growth angle. Promotes horizontal shoot growth.
Interaction partners:
Sequence:
MGLKVFHWLNRRMHSNTEYCSIHGSKAMEDKDSVPHSVVEKDTEALLLHDVLLNGILAIGTLGHHVDSLCPVACIEEDDLFIMDDEKAIVEERDDEEPRNDQVKEDVALETEPCEPVWPIVEPAKMHSLSMKEDNFTCFVAEEILIREVEDGGGANIQERPLLMLEKVEKVRTTLADLFAAEVFSSSSPREYSCQDIIDVAVASTSKHASCMEKMHQKKPRKPTPKPLKATRKLSRVMRKMLGKKIHPEQLNGRSNAEGPLTA
Protein: Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) (P23772)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Subcellular location: Nucleus {ECO:0000269|PubMed:15662016, ECO:0000269|PubMed:34644537}.
Interaction partners:
- T-box transcription factor TBX21
- Hepatocyte nuclear factor 3-alpha
- Runt-related transcription factor 1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Forkhead box protein P3
- Estrogen receptor
- Histone acetyltransferase p300
- Interferon regulatory factor 4
- Protein C-ets-1
- Nuclear receptor-interacting protein 1
Sequence:
MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG
Protein: Serine/threonine-protein phosphatase 4 regulatory subunit-like protein (Q8VY58)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine/threonine-protein phosphatase PP-X isozyme 2
- Serine/threonine-protein phosphatase PP-X isozyme 1
- Binding protein
- Serine/threonine-protein phosphatase 4 regulatory subunit-like protein
- Serine/threonine-protein phosphatase 2A activator
- Phytochrome-associated serine/threonine-protein phosphatase 3
- Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
- Serine/threonine-protein phosphatase PP1 isozyme 6
- Serine/threonine-protein phosphatase PP1 isozyme 7
- Phytochrome-associated serine/threonine-protein phosphatase 1
Sequence:
MENPSSSETSEISSVVHPNDGVHPNDGVHPNDGVQRQDHAVLPEVLEHPGAEQIADMSEEEVKRTLEAVASTGKFWQDWEILKGTLSYWLKKVLSEYSEAKMTDEQQKEALGEPYSELVSRLDEALLRFDDGPPFTLQRLCEILLAARSIYPKLSKLALALEKNLLVTSMLAISTEPQSQTTEDPNTATSETITSAASCDPNVIESMGGDKDEIMTEVEEADVDDAMTVDMETIDEPSETMTTTSESETLSENTAAQPLSDSMVAEEGDSRLPTTCA
Protein: Protein-arginine N-acetylglucosaminyltransferase SseK1 (Arginine GlcNAcyltransferase SseK1) (EC 2.4.1.-) (Salmonella secreted effector K1) (A0A0H3NK84)
Organism: Salmonella typhimurium (strain SL1344)
Function: Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling, apoptosis and necroptosis. Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins TRADD and, to a lower extent, FADD: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNF-alpha receptor complex, thereby disrupting TNF signaling. Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host GAPDH protein, thereby preventing GAPDH interaction with TRAF2, leading to inhibit NF-kappa-B signaling (By similarity). Catalyzes GlcNAcylation of host tubulin-folding cofactor TBCB, thereby promoting microtubule stability (By similarity). Also mediates auto-GlcNAcylation, which is required for activity toward death domain-containing host target proteins.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9L9J3}. Host cytoplasm, host cytosol {ECO:0000305|PubMed:32432056}. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 T3SS). {ECO:0000250|UniProtKB:Q9L9J3}.
Interaction partners:
Sequence:
MIPPLNRYVPALSKNELVKTVTNRDIQFTSFNGKDYPLCFLDEKTPLLFQWFERNPARFGKNDIPIINTEKNPYLNNIIKAATIEKERLIGIFVDGDFFPGQKDAFSKLEYDYENIKVIYRNDIDFSMYDKKLSEIYMENISKQESMPEEKRDCHLLQLLKKELSDIQEGNDSLIKSYLLDKGHGWFDFYRNMAMLKAGQLFLEADKVGCYDLSTNSGCIYLDADMIITEKLGGIYIPDGIAVHVERIDGRASMENGIIAVDRNNHPALLAGLEIMHTKFDADPYSDGVCNGIRKHFNYSLNEDYNSFCDFIEFKHDNIIMNTSQFTQSSWARHVQ