wanglab/gogpt-training-data huggingface dataset:
Protein: UPF0669 protein C6orf120 (Q7Z4R8)
Organism: Homo sapiens (Human)
Function: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:22340178}. Note=Secreted by hepatocytes.
Interaction partners:
- Erlin-1
Sequence:
MAAPRGRAAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHPSFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDASQEEESVLWTILISILKLVLEILF
Protein: Triacylglycerol lipase (EC 3.1.1.3) (Extracellular lipase) (Triacylglycerol ester hydrolase) (P0DUB8)
Organism: Burkholderia plantarii
Function: Catalyzes the hydrolysis of triacylglycerol.
Subcellular location: Secreted {ECO:0000305|PubMed:1476423, ECO:0000305|PubMed:8412704}. Note=Correct periplasmic folding, necessary for secretion, requires the lipase-specific foldase LifO (also called lipB). Secretion probably occurs via a type II secretion system. {ECO:0000269|PubMed:8412705, ECO:0000305|PubMed:8412704}.
Interaction partners:
Sequence:
MVRSMRSRVAARAVAWALAVMPLAGAAGLTMAASPAAVAADTYAATRYPVILVHGLAGTDKFANVVDYWYGIQSDLQSHGAKVYVANLSGFQSDDGPNGRGEQLLAYVKQVLAATGATKVNLIGHSQGGLTSRYVAAVAPQLVASVTTIGTPHRGSEFADFVQDVLKTDPTGLSSTVIAAFVNVFGTLVSSSHNTDQDALAALRTLTTAQTATYNRNFPSAGLGAPGSCQTGAATETVGGSQHLLYSWGGTAIQPTSTVLGVTGATDTSTGTLDVANVTDPSTLALLATGAVMINRASGQNDGLVSRCSSLFGQVISTSYHWNHLDEINQLLGVRGANAEDPVAVIRTHVNRLKLQGV
Protein: Sporozoite invasion-associated protein 2 (Q8IBC9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNMYVIYYYFLILIFINSCHLYLSSENQKKTIATVHNNTRTNTLKKNNSNNNNTNDIFGLSPSEVPNLIDDEEEYEILEGVKNNSDLTRSTNIDHPSPSSTMIDLDNIITEISKLKKKKLKKEMNNKLEQQTNQNNNTIHHNNENEINTFTQNIKTNSNELKNQDSSNSLISTNSNTMDELLLYSTNSEDNLDISFGELQLYENSDEDTSDYEYVNEDYSVNHIFSNDTEESFNILEDVENISLSSSNRYQYSPIGPYKKKHTKVFENFKMTRNYDEFLKLYNLKDSSDNQEEYYELLAGEPFKLNSYYYRDVKYENVKKYIFKEIYDNIQNISTENKIIVSKKEELFFYFIKSLLKNNFICLSYEEEENLLSESKLLLEAMISKKIQ
Protein: Voltage-dependent calcium channel alpha13 subunit (Q963J0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
LLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH
Protein: Protein S40-7 (AtS40-7) (Q9LKA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20238146}.
Interaction partners:
Sequence:
MNKNPRLDFSSPSSLATISDSADGELNEDDIFAIDISHAPPQARHSPVSSPAKQQTPARQLQRSKSGLKNVEASGILAALPESSGSSSYLSHVFHHKPAAALSTSVSSTASSSSSSGGGASAGSSSSARAIPTAPKPPQERLPFSASFVGGGKYPQSAPVQVPLVSSAMMNRHKKEFKLTDVVDDDEEEEEGEMLPPHEIVARSLAQSSLLSCSVLEGAGRTLKGRDLRQVRNAVFRRTGFID
Protein: Dopamine beta-hydroxylase (EC 1.14.17.1) (B3DGL8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000256|ARBA:ARBA00004553}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000256|ARBA:ARBA00004351}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004351}.
Interaction partners:
- Uncharacterized protein.
- Aromatic-L-amino-acid decarboxylase
- Amine oxidase.
- Amine oxidase [flavin-containing]
- Catechol O-methyltransferase B
- Catechol O-methyltransferase A
- Tyrosine 3-monooxygenase
- Transmembrane O-methyltransferase homolog
- Amine oxidase.
- Paired-like homeobox 2b
Sequence:
MRLINKDLRLQDVTLMYLTVLATVVVLLVASYQAPAGQSRPTLAYHIPLDPSGQLELSWNISYPKQEVLLEVKVKELHHGIILGMSDRGEPTNADLVILWDDGHKSYFGDAWSDSEGRVTLDTQQDYQLLETHQSTEGFFLLFKRSFSTCDPHDYIIEEGTVHIIYTMLEHPILSLHELNISRLQPGVQRVLLLRPDTPSPHLPKDVRTLEVLAPDVIIPTQETTYWCHIYQLPPNLPKNHIVMYESVITPGNEAIVHHIEVFECSPQMDIVPQYSGSCDSKMKPRNLNYCRHVLAAWAMGAEPFYYPADAGLPMGGEGSSRFLRLEVHYHNPLLLSGRRDSSGIRLWYSPSLRRFDAGIMELGLVYTPVMAIPPRQRSFQLTGYCTAKCTQTALPVGGIHIFASQLHTHLAGLGVRTVLVRGGQEVEVVQEDKHFSTHYQIIRVLQKMVTVLPGDALLTTCRFNTEDRSKVTVGGFGIMEEMCVNYVHYYPRTQLELCKSHVDTDYLQKYFSLINRFQGRESCSCPQTSVEEQFSSVSWDSFSGEVLNSLYVTAPFSMHCNQSTAQLFPGDWEKQEIPVVTAQLQRAPYPCEINRRVASNNDSPTEVRADSSG
Protein: Ras-related protein Rab-2B (EC 3.6.5.2) (P59279)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (By similarity). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:28930687, ECO:0000269|PubMed:34714330}; Lipid-anchor {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:34714330}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28063257}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000269|PubMed:34714330}.
Interaction partners:
- Golgi-associated RAB2 interactor protein 1A
- Golgi-associated RAB2 interactor protein 5A
Sequence:
MTYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRETFNHLTSWLEDARQHSSSNMVIMLIGNKSDLESRRDVKREEGEAFAREHGLIFMETSAKTACNVEEAYINTAKEIYRKIQQGLFDVHNEANGIKIGPQQSITSSVGPCSPQQNVSDIGPDSGCC
Protein: GTP-binding protein RHO1 (EC 3.6.5.2) (Rho-type GTPase 1) (P06780)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7.
Subcellular location: Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Peroxisome membrane; Lipid-anchor. Note=Plasma membrane-associated at sites of polarized growth such as incipient bud sites, bud tips, the bud neck during cytokinesis, and the neck and tip of mating projections. Also found on internal membranes of endosomes and peroxisomes.
Interaction partners:
- Protein kinase C-like 1
- 1,3-beta-glucan synthase component FKS1
- 1,3-beta-glucan synthase component GSC2
- RHO1 GDP-GTP exchange protein 2
- Exocyst complex component SEC3
- Protein BNI1
- GTPase-activating protein SAC7
- Rho GDP-dissociation inhibitor
- Rho1 guanine nucleotide exchange factor TUS1
- RHO1 GDP-GTP exchange protein 1
Sequence:
MSQQVGNSIRRKLVIVGDGACGKTCLLIVFSKGQFPEVYVPTVFENYVADVEVDGRRVELALWDTAGQEDYDRLRPLSYPDSNVVLICFSIDLPDSLENVQEKWIAEVLHFCQGVPIILVGCKVDLRNDPQTIEQLRQEGQQPVTSQEGQSVADQIGATGYYECSAKTGYGVREVFEAATRASLMGKSKTNGKAKKNTTEKKKKKCVLL
Protein: Energy-coupling factor transporter ATP-binding protein EcfA1 (ECF transporter A component EcfA1) (EC 7.-.-.-) (Q5M243)
Organism: Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Function: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity). Expression of the complex plus RibU in de-energized E.coli allows riboflavin uptake.
Subcellular location: Cell membrane {ECO:0000305|PubMed:23359690}; Peripheral membrane protein {ECO:0000305|PubMed:23359690}.
Interaction partners:
- Energy-coupling factor transporter transmembrane protein EcfT
- Energy-coupling factor transporter ATP-binding protein EcfA2
- Biotin transporter
- Biotin transporter
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- ABC transporter membrane-spanning protein
- DUF4115 domain-containing protein
- Conserved hypothetical, predicted membrane protein
- Cobalamin biosynthesis protein, putative transporter
Sequence:
MIEIKNLKFKYNQDQTSYTLNDVSFHVKHGEWLSIVGHNGSGKSTTARLIGGLLVADSGQIIVDGQELTEETVWDIRDKIGMVFQNPDNQFVGATVEDDVAFGLENKGLPYKEMVSRVQEALSFVGMMDFKDREPARLSGGQKQRVAIAGIIAMRPSILILDEATSMLDPEGRQELIQYIEDIRQQYGMTVLSITHDLDEVAMSNRVLVLKQGKVESISSPRELFSRGSELVDLGLDIPFSALLTQKLKNQGLIDCEGYLTEKELVEQLWEYLSKM
Protein: Transcription factor Nkx2-4a (Q58A07)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MSLSPKHTTPFSVTDILSPIEETYKKFSGMDGAGNLTSPLGAYRQPQVSQTGMQQHSMGHNATVATTYHMPHTVSQFSHSAMGGYCNGSIGNMGDLPSYQETMRNSAAATGWYGANTDPRYSTSMNMTGMGTLTGMGDASRSMPPLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQESNMCQQQQSPRRVAVPVLVKDGKPCQNGSNTPTPNQQQVQQQQQQQHNGSGVLPASSNAINQHQNQQVHSLVQAQDLEEISPSPPSLHSQINMAQIDTSAIDYTNNMVSSNLLYGRTW
Protein: Uncharacterized mitochondrial carrier C4G8.08 (Q09834)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDVQTLMAASAGAVASRLLCHPIDTITVHKQTIGKFSFKTMPLKAYYRGLPISLTLITPATCLYLSTYVEAKRRFKPSVGEGAILYSICGMTAEVVSSFVWTPLEVIKARTQISQKGSVINTISTLARSEGLKGFYRGYWMGVAIYLPTTVSWWVCYEESKKYLQKQSNWDISVIAPICSALGTVVATTISTPLDIVKTRYQVATSSAMRKAEYGLQAEKELGILEIAKLLFSKHGVKGFTRGLFTRMCYIMPSGMISMSVFESFKSKDID
Protein: Mitochondrial ribosomal protein S11 (RE01527p) (Q9VEN6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS10m
- LD06441p
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS15m
- 28S ribosomal protein S14
Sequence:
MSLKSVFLSALRSITMPAVPLQTSRIHTSACWRKAEDRKEMLASLPAKDEGTVGEKTVDIDTLINRKAKFFPDASTANTLFNGIPFNELPICNIRVSPNNTIISVTDHKGVLRLIRSCGIEGFKNTRKGTNIAAQATAVTISGKAIELGWKTVRVKVRGLGPGRMSAIKGLQMGGLNIVSITDNTHVSFNPPRPRKQRSL
Protein: Ionotropic receptor 92a (Q9VDN3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ionotropic receptor 25a
- Ionotropic receptor 64a
- Ionotropic receptor 8a
- Ionotropic receptor 84a
- Ionotropic receptor 31a, isoform C
- IP13856p
- Ionotropic receptor 21a
- Ionotropic receptor 75d
- Ionotropic receptor 40a
- Ionotropic receptor 75a
Sequence:
MLLQPLVMHLSQLLRIIVGQYFAEFPSILIVYNNSASTTPLQLEYLSALELVLRELSKPIRLQWINVAFLKDLNDLEDQVMGALNSSVTEGFITILSQTHHFIHARYYATRNANVRLKDKRYLFLCEDESPAELLCMDILQFYPHHLMVRPGTETAPTGPTGPHPDPRRGGGASVSTKNKDDGEGGAGNKTTSPYRDINFELWTQKFVGAVGNLDALLLDAFLPNETFANRVELYPNKLLNLQRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPNRSLTFDGAEANVMKTFCQVHNCHLRVEAYGADNWGGIYDNESSDGMLGDIYEQRVEMAIGCIYNWYDGITETSHTIARSSVTILGPAPAPLPSWRTNIMPFNNRAWLVLISTLVICGTFLYFMKYVSYRLRYSGTQVKFHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPRFFLATILCATITLENIYSGQLKSMLTFPFYSAPVDTIEKWAQSGWKWSAPSIIWVHTVQSSDLETEQILARNFEVHDYSYLSNVSFMPNYGFGIERLSSGSLSVGDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDKKKQEVLMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAELLIHRMDLSK
Protein: One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) (O95948)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
Subcellular location: Nucleus.
Interaction partners:
- Synaptotagmin-like protein 4
- Hepatocyte nuclear factor 3-beta
Sequence:
MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLHNAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLSTGGSSSTSSTCTKA
Protein: Zinc transporter 33D, isoform B (Q9VKA3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- FI23527p1
- Zinc transporter ZIP11
- Zinc/iron regulated transporter-related protein 102B, isoform E
- Zinc/iron regulated transporter-related protein 42C.2
- IP18018p
- FI24038p1
- Metallothionein-2
Sequence:
MSKKSLKRQDEHTKDNDCEEEDEEELQAAIREMVKIPDIDIIPRKSSESVREKESTGNVLKKNHDERGSQTGDGKDTTSKTRQKKLESDDSWAALLRKRFAWTKDNKTDAVNQNIPNTKGSSKDFTENKGSGNKHSTVTSNEKLIRSEYYENSQTKSDAIKSLSNNQLSEESPEFLNKLRRIEEASKPKTWKRPTPVVLKSNQNYSANKNSENALDAKPQTATNTEETHGCINILKVPFQSNLYYVPEKPSRQDKGSGTSDFQPGAPETPIVENSAVDSDRKAVEIMPENVKNSEEKKIDNSDSTKTVTITGHSHITAKWDGHCHFKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLASFLISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIMLITSALAILFNVIMAMQLQHGHSHSLPGVHKMSKDAGSVLGSKMILLLGKSVSMQYAAKGHENINVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRDVLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAISKDADPQLILEEATTLIHKRFKFFETTIQIEEYSPGMENCGQCLSPSDKSGKRKSSDPEKGEGKAGRKRGSDVGKIKNHSGSE
Protein: Homeodomain protein Hb9 (Motor neuron and pancreas homeobox 1) (Motor neuron and pancreas homeobox protein 1) (Q6SYZ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Insulin gene enhancer protein isl-1
- DNA-binding protein RFX6
- Pancreas transcription factor 1 subunit alpha
- Paired box 4.
- Oligodendrocyte lineage transcription factor 2.
- Neurogenic differentiation factor 1
- Insulin gene enhancer protein isl-2a
- Neurog3 protein
Sequence:
MEKSKNFRIDALLAVDPPKVQTSPLALVTSLPTSSISSSSDSVQAVELTTNSDALQTESPSPPRISSCGLIPKPGFLNSPHSGMVGLHPQSSTGIPPQALYGHPMYTYSAAALGQHPALSYSYPHGSHHHHHPSDPLKLTASSFQLDHWLRVSTAGMMLPKMADFNGQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQDAEKQKGKGNHDKMDGLEKDYQKVDSGKSNRIRDFRDSDDEEGDNYMLNSSDCSSEDERTNDISPQP
Protein: Putative cytochrome P450 2D7 (EC 1.14.14.1) (A0A087X1C5)
Organism: Homo sapiens (Human)
Function: May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine. However, another study could not confirm it.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000305|PubMed:15051713}. Mitochondrion {ECO:0000269|PubMed:18838503}.
Interaction partners:
Sequence:
MGLEALVPLAMIVAIFLLLVDLMHRHQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLPHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVGNLFLAGMVTTSTTLAWGLLLMILHLDVQRGRRVSPGCPIVGTHVCPVRVQQEIDDVIGQVRRPEMGDQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWKKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRVVSFLVTPSPYELCAVPR
Protein: Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) (P25296)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit A2
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
- FK506-binding protein 1
- Transcriptional regulator CRZ1
- Calcium-channel protein CCH1
- Calcium/calmodulin-dependent protein kinase II
- Calcium-transporting ATPase 2
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Serine/threonine-protein phosphatase PP1-1
Sequence:
MGAAPSKIVDGLLEDTNFDRDEIERLRKRFMKLDRDSSGSIDKNEFMSIPGVSSNPLAGRIMEVFDADNSGDVDFQEFITGLSIFSGRGSKDEKLRFAFKIYDIDKDGFISNGELFIVLKIMVGSNLDDEQLQQIVDRTIVENDSDGDGRLSFEEFKNAIETTEVAKSLTLQYDV
Protein: N-acetylglucosamine-1-phosphate transferase subunit gamma (A0A8I5Y9M2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKVVEEPNTFGLNNPFLPQASRLQPKREPSAVSGPPHLFRLAGKCFSLVESTYKYEFCPFHNVTQHEQTFRWNAYSGILGIWHEWEIVNNTFKGMWMTDGDSCHSRSRQSKVELTCGKTNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLSEALQQRWDQVEQDLADELITPQVGAHSGWGGPLSYATRYSSYLLHLQGYEKLLRALFEDAGYLKVPGETHPTQLAGDSKGLGLETLDICRKAHAELSREVQRLTSLLEQHGIPHTQPTETTHSQLLGQQLPVGEISEQLRGDPGLRGNIL
Protein: Biotin attachment protein (Q729X3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha
- biotin carboxylase
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Bifunctional ligase/repressor BirA
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Conserved domain protein
- Uncharacterized protein
- Biotin--acetyl-CoA-carboxylase ligase
- Malonyl CoA-acyl carrier protein transacylase
- Riboflavin biosynthesis protein RibD
Sequence:
MLDVTKLLEEIKASPYEEIQVVAPHCGVVTFGDLAVGTRVRGVSGMWKEKPGTLLATIEREHNKKPIHAGEKGEVTSIETSLEGRFVEARTPLMVIRHFLSRDEVLRIILQRTLNLFNAPERAKYYFTPDVDKKIKASGSRSVTVHDGMELFIMSRMKREVSLGYSGPDGVIYAVYFQHNENVDAGQPLIGVCPQEQLPLIEEVVARVQTEWEERE
Protein: Primary cilium assembly protein FAM149B1 (Q96BN6)
Organism: Homo sapiens (Human)
Function: Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development.
Subcellular location: Cell projection, cilium {ECO:0000305|PubMed:30905400}.
Interaction partners:
- DnaJ homolog subfamily C member 9
- Protein broad-minded
- Cilia- and flagella-associated protein 20
Sequence:
MISRYTRKAVPQSLELKGITKHALNHHPPPEKLEEISPTSDSHEKDTSSQSKSDITRESSFTSADTGNSLSAFPSYTGAGISTEGSSDFSWGYGELDQNATEKVQTMFTAIDELLYEQKLSVHTKSLQEECQQWTASFPHLRILGRQIITPSEGYRLYPRSPSAVSASYETTLSQERDSTIFGIRGKKLHFSSSYAHKASSIAKSSSFCSMERDEEDSIIVSEGIIEEYLAFDHIDIEEGFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDSVWCKVVSCMEQLTRSHWEGFASDDESNVAVTRPDSESSCVLSELHPLVLPRVPQSKVLYITSNPMSLCQASRHQPNVNDLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTILSTRNWPNRAVEFSTSSLSYTVQSTRRRNPPPRTLHPISTSHSCAETPRSVEEILRGARVPVAPDSLSSPSPTPLSRNNLLPPIGTAEVEHVSTVGPQRQMKPHGDSSRAQSAVVDEPNYQQPQERLLLPDFFPRPNTTQSFLLDTQYRRSCAVEYPHQARPGRGSAGPQLHGSTKSQSGGRPVSRTRQGP
Protein: Origin recognition complex subunit 3 (Origin recognition complex 62 kDa subunit) (P54790)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
Subcellular location: Nucleus.
Interaction partners:
- Origin recognition complex subunit 6
- DNA replication licensing factor MCM2
- Nucleolar complex-associated protein 3
- Minichromosome maintenance protein 5
- Origin recognition complex subunit 5
- Cell division cycle protein CDT1
- Origin recognition complex subunit 1
- Origin recognition complex subunit 2
- Cell division control protein 6
- Origin recognition complex subunit 4
Sequence:
MSDLNQSKKMNVSEFADAQRSHYTVYPSLPQSNKNDKHIPFVKLLSGKESEVNVEKRWELYHQLHSHFHDQVDHIIDNIEADLKAEISDLLYSETTQKRRCFNTIFLLGSDSTTKIELKDESSRYNVLIELTPKESPNVRMMLRRSMYKLYSAADAEEHPTIKYEDINDEDGDFTEQNNDVSYDLSLVENFKRLFGKDLAMVFNFKDVDSINFNTLDNFIILLKSAFKYDHVKISLIFNINTNLSNIEKNLRQSTIRLLKRNYHKLDVSSNKGFKYGNQIFQSFLDTVDGKLNLSDRFVEFILSKMANNTNHNLQLLTKMLDYSLMSYFFQNAFSVFIDPVNVDFLNDDYLKILSRCPTFMFFVEGLIKQHAPADEILSLLTNKNRGLEEFFVEFLVRENPINGHAKFVARFLEEELNITNFNLIELYHNLLIGKLDSYLDRWSACKEYKDRLHFEPIDTIFQELFTLDNRSGLLTQSIFPSYKSNIEDNLLSWEQVLPSLDKENYDTLSGDLDKIMAPVLGQLFKLYREANMTINIYDFYIAFRETLPKEEILNFIRKDPSNTKLLELAETPDAFDKVALILFMQAIFAFENMGLIKFQSTKSYDLVEKCVWRGI
Protein: Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16) (Q969J5)
Organism: Homo sapiens (Human)
Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Subcellular location: Secreted {ECO:0000269|PubMed:12700595}.
Interaction partners:
- Interleukin-22
- Interleukin-10 receptor subunit beta
- Interferon lambda-3
- Interferon lambda-1
- Interleukin-19
- Interferon lambda-2
- Interleukin-24
- Interleukin-22 receptor subunit alpha-1
- Interleukin-10
- Interferon gamma
Sequence:
MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVYFVQYKIMFSCSMKSSHQKPSGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP
Protein: Interferon gamma2 (E3P8T4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDVLSRAVMCFCLMGWMTLGWSNAAQYTSINMKRNIDKLKVHYKISKDQLFNGNPVFPKDTFEDSEQRVLMSVVLDVYLSIFSQMLNQTGDQEVRERLDQVKGKVQETQKHYFLGRIPELRTHLQNLWAIKTSDTTVQGKALSEFITIYEKASKLAHEIHLKKDNRRKRRQAQRLKSHIM
Protein: Probable trans-aconitate 2-methyltransferase (EC 2.1.1.144) (P9WGA3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00560}.
Interaction partners:
- Conserved protein
- Possible conserved exported protein
- Conserved protein
Sequence:
MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLTRYLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG
Protein: RING/U-box superfamily protein (RNA-binding protein-like protein) (Q8L8N5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
Sequence:
MAKLSFKDSLKALEADIQHANTLALDYPREKDGARVQMRLSYSPTAQFFLFLVQWTDCKLAGFLGLLRVLIYMTYADGKTTMSVYERKASIREFQAVILPSLSQLQRGVTDIDDSKQKEVCKMRYRKKDESEMSEIEIEREEECGICMEMNSKVVLPNCTHSLCIKCYRDWRGRSQSCPFCRDSLKRVDSGDLWMFLDQNDTVNLTAIARENQKRLFMYIEKLPLVVPDQVYASSPYDFHVR