wanglab/gogpt-training-data huggingface dataset:
Protein: Xanthine dehydrogenase (EC 1.17.1.4) (Purine hydroxylase I) (Q12553)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).
Subcellular location: Peroxisome {ECO:0000250}.
Interaction partners:
- Uricase
- Purine nucleoside phosphorylase
- Guanine deaminase
- Nicotinate hydroxylase hnxS
- Positive regulator of purine utilization
Sequence:
MAPGVLLQPSQSELEAASPPKAAASLLQLTEEWDDTIRFYLNGTKVILDSVDPEITLLEYLRGIGLTGTKLGCAEGGCGACTVVVSQINPTTKKLYHASINACIAPLVAVDGKHVITVEGIGNVKNPHAIQQRLAIGNGSQCGFCTPGIVMSLYALLRNDPKPSEHAVEEAFDGNLCRCTGYRPILDAAQSFTSPIGCGKARANGGSGCCMEEQKGTNGCCKGSSEETTEDVKHKFASPDFIEYKPDTELIFPPSLWKHELRPLAFGNKRKKWYRPVTVQQLLEIKSIHPDAKLIGGSTETQIEIKFKQMRYGASVYLGDLAELRQFAFHDNYLEIGANISLTDLESVCDQAIERYGSARGQPFAAIKKQLRYFAGRQIRNVASPAGNLATASPISDLNPVFVATNTTLVARSLDKETEIPMTQFFRGYRSTALPPDAIISSLRIPTASEKGEYLRAYKQSKRKDDDIAIVNAALRVSLSSSNDVTSVSLVFGGMAPLTVSARNAEAFLTGKKFTDPATLEGTMGALEQDFNLKFGVPGGMATYRKSLALGFFYRFYHDVLSQIEARSSDLDNSVVAEIERAISTGEKDNEASAAYQQRVLGRAGPHLSALKQATGEAQYTDDIPAQKNELYGCMVLSTKAHAKLLSVNTEAALEIPGVIDYVDHKDLPSPRANWWGAPNCDEVFFAVDKVTTAGQPIGMILANTAKAAEEGARAVKVEYEELPVILSIEEAIEAQSFFERFRYIKNGDPESAFRDADHVFEGVSRMGGQEHFYLETQACVAIPKAEDGEMEIWSSTQNPTETQSYVAQVTGVAANKIVSRVKRLGGGFGGKETRSVQLAGICATAAAKVRRPVRCMLNRDEDIATSGQRHPFYCKWKVGVTREGKLLALDADVYANGGHTQDLSGAVVERSLSHIDNVYRFPNIYVRGRICKTNTVSNTAFRGFGGPQGLFFAESIISEVADHLDLQVEQLRILNMYEPGDMTHFNQELKDWHVPLMYDQVLQESEYFERRKAVEEYNRTHKWSKRGMAIIPTKFGISFTALFLNQAGALVHIYHDGSVLVAHGGVEMGQGLHTKMTMIAAEALGVPLSDVFISETATNTVANTSSTAASASSDLNGYAIYNACTQLNERLKPYREKMPNATLKDLAHAAYFDRVNLSAQGYYRTPDIGYTWGENKGQMFFYFTQGVTAAEVEIDTLTGDWTPLRADIKMDVGRTINPSIDYGQIEGAYIQGQGLFTTEESLWHRTTGQIFTKGPGNYKIPGFRDIPQIFNVSLLKDVEWENLRTIQRSRGVGEPPLFMGSAAFFAIRDALKAARKEWGVTDVLSLVSPATPERIRVSCADPIIERARVKAEEGEKSFFVAI
Protein: Nucleoporin 54 (Zgc:77551) (Q6NYN9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Nuclear pore glycoprotein p62
- Nucleoporin 214.
- Nuclear pore complex protein
- Nucleoporin 205.
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup93
- Nucleoporin 155.
- Nuclear pore complex protein Nup153
- Nuclear pore complex protein Nup98-Nup96
- Nucleoporin NUP35
Sequence:
MAFNFGGASGSASAPGFSFKSSSSTPFGFGASTTTTASSATGFGLTGTGFGAPTTTSASTGFGFGTGGTAGAFGGFGSTTTSAGTGSSFSFSTPANTGSSLFNTQSKGFGFSSAPAPASGFTGALGGGALGFGGFGALQNTQQGGVFGQQAPPPCSQLFNTASALSAPAVLSDERDSILARWNQLQAFWGIGRGYYCSTTPPVEFSQENPFCRFKAVGYSCVPDVRDEDGLLALALGKREADVRLQQQQLVESLHKLLGGAHTLSVNVEGVRALPDDQTEVIIYVVERSPNGSSKRVPASTLYNFLEQVNIKTQLQQLSVIMTVSRTALSPAQLKQLLQNPPRRCGPHHLGTG
Protein: Signal transducing adapter molecule 1 (STAM-1) (Q92783)
Organism: Homo sapiens (Human)
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Subcellular location: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}.
Interaction partners:
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- STAM-binding protein
- Tumor susceptibility gene 101 protein
- Polyubiquitin-C
- Signal transducing adapter molecule 2
- Ubiquitin-ribosomal protein eS31 fusion protein
- Tyrosine-protein kinase JAK3
- Vacuolar protein-sorting-associated protein 36
- Polyubiquitin-B
- Tyrosine-protein kinase JAK2
Sequence:
MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNAQMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAPVYSPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL
Protein: Uncharacterized protein YahC (P77219)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YaiA
- Medium-chain fatty-acid--CoA ligase
Sequence:
MNGLTATGVTVGICAGLWQLVSSHVGLSQGWELLGTIGFVAFCSFYAAGGGKSGFIRSLAVNYSGMVWAFFAALTAGWLASVSGLSAFWASVITTVPFSAVVVWQGRFWLLSFIPGGFLGMTLFFASGMNWTVTLLGFLAGNCVGVISEYGGQKLSEATTKRDGY
Protein: Calcium-binding protein CBP (OsCBP) (Q2QY10)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Potential calcium sensor.
Interaction partners:
- Calpain-type cysteine protease ADL1
- Os03g0322000 protein
- Os07g0686400 protein
- Putative nitric oxide synthase
Sequence:
MAGYPPNPGSGYPYGGAGGYGAPPPPYGSSPAPSAPPYGAKPPKEGKTSSSSAPYYGGGGGYGAPPSTQPYGSGGGYGAPPSSQPYGAPYGAPPPSSAPYGAPGGYGSPFASLVPSAFPPGTDPNVVACFQAADRDGSGMIDDKELQSALSGYSQSFSLRTVHLLMYLFTNTNVRKIGPKEFTSVFYSLQNWRSIFERFDRDRSGKIDATELRDALLSLGYSVSPTVLDLLVSKFDKTGGKNKAIEYDNFIECCLTVKGLTEKFKEKDTAFSGSATFTYEAFMLTVLPFLIA
Protein: Syntaphilin (O15079)
Organism: Homo sapiens (Human)
Function: Inhibits SNARE complex formation by absorbing free syntaxin-1.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Synapse, synaptosome.
Interaction partners:
- Syntaxin-1A
- Trafficking kinesin-binding protein 1
- Synaptosomal-associated protein 25
- Mitochondrial Rho GTPase 1
- Kinesin-1 heavy chain
- Protein bassoon
- Trafficking kinesin-binding protein 2
- Disrupted in schizophrenia 1 protein
- Syntabulin
- Synaptophysin
Sequence:
MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPASNTYEKLLCGMEAGVQASCMQERAIQTDFVQYQPDLDTILEKVTQAQVCGTDPESGDRCPELDAHPSGPRDPNSAVVVTVGDELEAPEPITRGPTPQRPGANPNPGQSVSVVCPMEEEEEAAVAEKEPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCRSLSQPSPSPAGGGSQL
Protein: Cytochrome P450 2D4 (EC 1.14.14.1) (CYPIID18) (CYPIID4) (Cytochrome P450 2D-29) (Cytochrome P450 2D-35) (Cytochrome P450 2D18) (Cytochrome P450-CMF3) (Cytochrome P450-DB4) (Debrisoquine 4-hydroxylase) (Q64680)
Organism: Rattus norvegicus (Rat)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 7A1
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- Steroid 17-alpha-hydroxylase/17,20 lyase
- UDP-glucuronosyltransferase 2B37
- UDP-glucuronosyltransferase 2B15
- Nuclear receptor subfamily 1 group I member 2
Sequence:
MRMPTGSELWPIAIFTIIFLLLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQIDFQNMPAGFQKLRCRFGDLFSLQLAFESVVVLNGLPALREALVKYSEDTADRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQRRFSVSTFRHFGLGKKSLEQWVTEEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEEESGFLPMLLNVFPMLLHIPGLLGKVFSGKKAFVAMLDELLTEHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTTSTTLTWALLFMILRPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQGFLIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSNYGVFGALTTPRPYQLCASPR
Protein: Heparanase-like protein 1 (EC 3.2.-.-) (Q9FF10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans (By similarity).
Subcellular location: Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}.
Interaction partners:
- Heparanase-like protein 3
- Heparanase-like protein 2
- F-box protein At1g47056
- Exosome complex exonuclease RRP44 homolog A
Sequence:
MGFRVCVIVVFLGCLLLVPEKTMAQEMKRASIVIQGARRVCETDENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIKAFKPLRIRIGGSLQDQVIYDVGNLKTPCRPFQKMNSGLFGFSKGCLHMKRWDELNSFLTATGAVVTFGLNALRGRHKLRGKAWGGAWDHINTQDFLNYTVSKGYVIDSWEFGNELSGSGVGASVSAELYGKDLIVLKDVINKVYKNSWLHKPILVAPGGFYEQQWYTKLLEISGPSVVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGPWASPWVGESGGAYNSGGRHVSDTFIDSFWYLDQLGMSARHNTKVYCRQTLVGGFYGLLEKGTFVPNPDYYSALLWHRLMGKGVLAVQTDGPPQLRVYAHCSKGRAGVTLLLINLSNQSDFTVSVSNGINVVLNAESRKKKSLLDTLKRPFSWIGSKASDGYLNREEYHLTPENGVLRSKTMVLNGKSLKPTATGDIPSLEPVLRSVNSPLNVLPLSMSFIVLPNFDASACS
Protein: Peptidoglycan recognition protein 6 (A0A0R4IJX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMGRQFISVCLRKGQDGFKRRASSEANTQSDFIIRGYLALNYSVFMMDLRLFSLLMLFACGIAEATTLKRMDDFISAVESIEAVNPALSMLDVLKGLRKASGLETDLSQQLLGDAHPELTMDPSVASNIHELINHHVSDITEEGVVLTLDGSNVALAPLLLGLEAGLQSIDLYPLTLTENLLNSFVHHVQNQESSALLGTKGYWDSIKSPRVYTLSGLPSLATDALIIGGMDGFILGSEMASSDHPEESLSSLLRSYYSQKLDDAAPRLISQKRRMNFRNMADFSLMKTQVVRALTVRRNLNQDERKKLDDVVNEGFEEFVHVYAVCPNIITRSQWGAASYIGSPSYLSLPVRYLFIHHTYQPSKPCTTFEQCAAEMRSMQRYHQQSNGWSDIGYSFVAGSDGNLYEGRGWNWVGAHTYGYNSIGYGVCFIGDYTSTLPASSAMNMVRYDFTYCATNGGRLSKSYSLYGHRQAAATECPGNTLYRQIQTWERYQSYLP
Protein: Zinc finger protein ZIC 3 (XZic3) (XlZic3) (Zinc finger protein Zic3-A) (Zinc finger protein of the cerebellum 3) (O57311)
Organism: Xenopus laevis (African clawed frog)
Function: Probably acts as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development. Involved in establishing left-right asymmetry in the embryo.
Subcellular location: Nucleus. Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MTMLLDGGPQFPTLGVGGFGTARHHEMSNRDAGMGLNPFTEPSHAAAFKLSPASHDLSSSQSSAFTPQASGYASSLGHHAGQVPSYGGAAFNSTRDFLFRNRNSGIADSSSAGSQHGLFANHGPPGIGEPPGHLIFPGLHEQSSSHTSSNGHVVNGQMHLGLRGDIFGRPDPYRAVPSPRTDHYAAAQFHNYNHMNMSMNVAAHHGQGAFFRYMRQPIKQELSCKWLEESTMNHPQKTCDRTFSSMHELVTHMTMEHVGGPEQNNHICYWEECPRGGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESATPPAMVSANSEEPSKNSSATHQTNNNSHNTGLLPPNFNEWYV
Protein: EHMT2 (A0A024RCN9)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
Sequence:
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
Protein: Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) (Q9NY59)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:10823942}; Lipid-anchor {ECO:0000269|PubMed:10823942}. Cell membrane {ECO:0000269|PubMed:15051724}; Lipid-anchor {ECO:0000269|PubMed:15051724}. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:10823942). Localizes to plasma membrane in confluent contact-inhaibited cells (PubMed:15051724).
Interaction partners:
- Sphingomyelin phosphodiesterase 2
- Sphingomyelin phosphodiesterase 4
- Sphingomyelin phosphodiesterase
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Ceramide synthase 2
- Ceramide glucosyltransferase
- Ceramide synthase 6
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
- Ceramide synthase 4
Sequence:
MVLYTTPFPNSCLSALHCVSWALIFPCYWLVDRLAASFIPTTYEKRQRADDPCCLQLLCTALFTPIYLALLVASLPFAFLGFLFWSPLQSARRPYIYSRLEDKGLAGGAALLSEWKGTGPGKSFCFATANVCLLPDSLARVNNLFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGVARAVPGSIKRTASVEYKGDGGRHPGDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANSKLLYKASVVKKAAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMDVAYHCYPNKCNDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAIRCGQLDLLQDWLADFRKSTSSSSAANPEELVAFDVVCGDFNFDNCSSDDKLEQQHSLFTHYRDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSSGQKGRKELLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSSGEEEA
Protein: Probable nucleolar protein 5-2 (MAR-binding NOP56/58 homolog 2) (Nucleolar protein 58-2) (Q9MAB3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for 60S ribosomal subunit biogenesis.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein At3g06530
- Nucleolar protein 56
- Nucleolar protein 56
- Nucleolar protein
- rRNA 2'-O-methyltransferase fibrillarin 2
- Putative WD-repeat membrane protein
- Transducin family protein / WD-40 repeat family protein
- H/ACA ribonucleoprotein complex subunit 2-like protein
- U3 small nucleolar RNA-associated protein 18 homolog
- rRNA 2'-O-methyltransferase fibrillarin 1
Sequence:
MVLVLYETAAGFALFKVKDEGKMANVEDLCKEFDTPDSARKMVKLKAFEKFDNTSEALEAVAKLLEGAPSKGLRKFLKANCQGETLAVADSKLGNVIKEKLKIDCIHNNAVMELLRGVRSQFTELISGLGDQDLAPMSLGLSHSLARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGNRVNAAKLDFSEILADEIEADLKDAAVISMGTEVSDLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSLLNLSKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASLVGQAAPKHKGKISRSLAAKTVLAIRVDALGDSQDNTMGLENRAKLEARLRNLEGKDLGRLSGSSKGKPKIEVYNKDKKMGSGGLITPAKTYNTAADSLLGETSAKSEEPSKKKDKKKKKKVEEEKPEEEEPSEKKKKKKAEAETEAVVEVAKEEKKKNKKKRKHEEEETTETPAKKKDKKEKKKKSKD
Protein: Bromodomain-containing protein bet-1 (Q95Y80)
Organism: Caenorhabditis elegans
Function: Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants. Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells. Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway. Involved in adult locomotion. Acts together with the sumoylation pathway to prevent muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression. May play a role in vulva development.
Subcellular location: Nucleus {ECO:0000269|PubMed:20181741}. Chromosome {ECO:0000269|PubMed:20181741}. Note=Localizes to granular structures in interphase and co-localizes with chromosomes during metaphase. {ECO:0000269|PubMed:20181741}.
Interaction partners:
- Probable cyclin-dependent kinase 9
- RRM domain-containing protein
Sequence:
MSEGSGDQSQQRPWASPRQQPIKGIVQPRVLPPFGKPTRHTNKLDYIMTTVLKEAGKHKHVWPFQKPVDAVALCIPLYHERVARPMDLKTIENRLKSTYYTCAQECIDDIETVFQNCYTFNGKEDDVTIMAQNVHEVIKKSLEQAPREEHDMDVYWGKNKKKPAKSDGGSKSSSSKKNDARGPSEAPSEAGSEVSSVTTASAAAPTVSESASVAAKPERKVAGKKTGKRKAESEDDEKPEPLRAKREVAVVKKEVHQPLLPSMKPCLKLLNDFSTKKYQEFAWPFNEPVDAEQLGLHDYHKIIKEPMDLKSMKAKMESGAYKEPSDFEHDVRLMLRNCFLYNPVGDPVHSFGLRFQEVFDRRWAELGDSSSRASSVAPQSAPIAPTPKVAKSSAPKEPKESRKEHKKETTFEASGAKSEDLMQINNALSMIREREEKLKAELAAAQAIKDKLTSVKNRREDNPNEPFPEKLINETRALCTTQVGQNASSSSASSAALRNGRSKKAASARLYGYEFDSDDEDNKMALTYEEKRNLSNLINNLPNNQLNTIISIIQRRERSALMQQQLDDSEVELDFESLGDMCLREMGAFIKTIPTLNGNGDDEKPKTSSNPTSSGATGSKGSSSLESKNGKKKKNFNMSESSDDETSNSRKRRKRESSESQSSSSSDDDSDDEDRPSIPRKSGQPPSTSREWNQSSAPPPRMGGMGGQPPMSRVPASSSTSVSAIGKNNAAASSNSYQAPKPAPVPAPTSSRPPAAPRPPSKPKKTGGASILDTLLPDTFGASPPQFFQSQPTTSATIRSPTESQPGNGEDEQTRIQRMRMEAKRARQKEDEGSVSLSNQMEMMAAFEFDNTY
Protein: ESX-3 secretion system protein EccD3 (ESX conserved component D3) (Type VII secretion system protein EccD3) (T7SS protein EccD3) (P9WNQ3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:B2HSU6}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ESX-3 secretion system ATPase EccB3
- ESX-3 secretion system protein EccC3
- ESX-3 secretion system protein EccE3
- ESX-3 secretion-associated protein EspG3
- Mycosin-3
- ESX-5 secretion system ATPase EccB5
- ESAT-6-like protein EsxG
- ESX-3 secretion system protein EccA3
- PPE family protein PPE4
- ESX-5 secretion system protein EccC5
Sequence:
MSGTVMQIVRVAILADSRLTEMALPAELPLREILPAVQRLVVPSAQNGDGGQADSGAAVQLSLAPVGGQPFSLDASLDTVGVVDGDLLVLQPVPAGPAAPGIVEDIADAAMIFSTSRLKPWGIAHIQRGALAAVIAVALLATGLTVTYRVATGVLAGLLAVAGIAVASALAGLLITIRSPRSGIALSIAALVPIGAALALAVPGKFGPAQVLLGAAGVAAWSLIALMIPSAERERVVAFFTAAAVVGASVALAAGAQLLWQLPLLSIGCGLIVAALLVTIQAAQLSALWARFPLPVIPAPGDPTPSAPPLRLLEDLPRRVRVSDAHQSGFIAAAVLLSVLGSVAIAVRPEALSVVGWYLVAATAAAATLRARVWDSAACKAWLLAQPYLVAGVLLVFYTATGRYVAAFGAVLVLAVLMLAWVVVALNPGIASPESYSLPLRRLLGLVAAGLDVSLIPVMAYLVGLFAWVLNR
Protein: Galactofuranosyltransferase GlfT1 (GalTr 1) (EC 2.4.1.287) (Arabinogalactan galactosyltransferase 1) (Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase) (UDP-Galf:alpha-3-L-rhamnosyl-alpha-D-GlcNAc-pyrophosphate polyprenol, galactofuranosyl transferase) (A0R5Z2)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP-galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho-decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl-galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha-GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 continues with the subsequent polymerization events.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P9WMX3}. Secreted, cell wall {ECO:0000250|UniProtKB:P9WMX3}.
Interaction partners:
- O-antigen export system, permease protein
- O-antigen export system, ATP-binding protein
- Galactofuranosyltransferase GlfT2
- Bacterial proteasome activator
- UDP-galactopyranose mutase
- Decaprenyl-phosphate N-acetylglucosaminephosphotransferase
- Galactan 5-O-arabinofuranosyltransferase
- Primosomal protein
- Alpha-
- Uncharacterized protein
Sequence:
MTHTEVVCAVVVTHRRRELLATSLDAVVSQDRKPDHLIVVDNDNDPQVRELVTGQPVPSTYLGSRRNLGGAGGFALGMLHALALGADWIWLADDDGRPADTTVLSTLLSCAHTHSLAEVSPMVCNLDDPQRLAFPLRRGLVWRRLTSELRTDSSSSSGDLLPGIASLFNGALFRADTVDAVGVPDLRLFVRGDEVELHRRLVRSGLPFGTCLTASYLHPCGTDEFKPILGGRMHTQYPDDETKRFFTYRNRGYLLSQPGLRKLLPQEWLRFGWYFLVSRRDLAGLREWIRLRRLGRRERFQR
Protein: Troponin T type 2a (cardiac) (Troponin T, cardiac muscle isoform X2) (F1R0K6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDNEEVEEYEEQEEAQQEENAGGDEETTQEHDGEEETEDGGEEAKPKFLKPFMLPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQTLIEAHFESRKKEEEEIISLKDRIEKRRSERAEQQRIRSERERERQKRLEEERARKEEEEAKKRAEDDAKKKKTLTSLHFGGYMQKIERRSGKKQTEREKKKKILGDRRKPLDIDNANESALREKAKELWSWMRELEAEKFELQYQFGKQKYEINVLRNRVSDHQKLSKRTKRGLRK
Protein: Temporin-CDYb (B3VZU4)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus (MIC>100 uM) and the Gram-negative bacterium E.coli (MIC>100 uM). Has weak hemolytic activity against human erythrocytes.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P56918}.
Interaction partners:
Sequence:
MFTLKKSLLLLFFLGTINLSLCEEERDADEEERRDDPEERAVQVEKRILPILAPLIGGLLGK
Protein: CCAAT enhancer binding protein alpha/gamma homolog (Q4H3U0)
Organism: Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASRSNPNLNSGAGAHKNYMSADNTLDFTDLYQNEESFDLSCYMSTSPNLELCNDDLFENLFPPTSPSLPADLKKEKFEDFEEELDNWYYTTTSEPPSNCASACSSAAPSPVPYNFYNTPPVTPQRPQSPHHLQFDGLTTPMSSSRFAAVMAEDRQVLQQRQVPQRINESNMPISTPIIVKPDPEEQMYLTEQSFANMKDEPVTANHVPTSIASQPDIDTKTMKRPAPIDYSSSKKTKILIKGSKEYVQKRERNNVAVRRSRDKAKRKAAETQVKVDQLQNENLKLHEKVAELTHELTTLKNLLKALPHAQS
Protein: Probable E3 ubiquitin-protein ligase EDA40 (EC 2.3.2.27) (Protein EMBRYO SAC DEVELOPMENT ARREST 40) (RING-type E3 ubiquitin transferase EDA40) (F4JSV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable E3 ubiquitin-protein ligase involved in female gametophyte development. Required for fusion of polar nuclei in the embryo sac.
Interaction partners:
- Magnesium-chelatase subunit ChlI-2, chloroplastic
- Magnesium-chelatase subunit ChlI-1, chloroplastic
- Magnesium-chelatase subunit ChlH, chloroplastic
- Pollen Ole e 1 allergen and extensin family protein
- Dof zinc finger protein DOF4.4
- Defensin-like protein 97
- Uncharacterized protein
- Protein CLP1 homolog
- Probable methyltransferase PMT5
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Sequence:
MMNGLRRTFWSSIHKKKDNNRVDDSLDRQKPTTTSRFGFFSNPSTPRSETRPDSVTCSPTIPCQSWSATAISTPSPSLPASPKLQCDTSGDVTPTRNRSPLSFLSVSSSSSTPSSPKSPASFSLLKSKLCFTKVRILNRNNQVNIFKNNSKLTFLRLCYEQSSISSSKCGICLQSAKAGRGTAIFTAECSHTFHFPCVASRAGDRNLLSDCPVCGASWRETSLLPLSLSSSLHESGSESDSKIRESKNNNKSLRVYNDDEPLISSPISRTGFNTIPESNEDEEEEDNDDGEFKGFYVNTPSPLTTKKMLTDSVTGHVDVKLSSEAAIVAVGRGNETYSVLMKIKSPSLPTARRSPVDLVTVIDVSGGNIEMVKRAMRQVISSLRETDRLSMVSFSSSSKRLTPLRRMTANGRRLARRIVDDISGDGDGMSVNDAVKKAAKVIEDRRQKNLFTTIFVLTDRNRNSAHQAQLAQPDFVTSTRFSHLEIPTHTIWLGACNHALPEDVFAKRIKSLLSLSVQDLTLNLGLVSGSGQGKVTSVYSLSGRPVWLGSGLIRLGDMYGDEEREVLVELKSPSSSRSQRIMTVRSRHVDPTTQEIKNYEDRALMIPRPTTVRSSDPSIARLRNLHVSTRAVAESRRLVEVNDYSGAERMLTSARALLVQYGLSSSDSCLRGLEAELADLNRLRGRHVAVKSPEPVVQKSEPLTPTSAWRAAERLAKVAIMRKHMNRVSDLHGFENARF