wanglab/gogpt-training-data huggingface dataset:
Protein: Protein DDI1 homolog 1 (EC 3.4.23.-) (Q17569)
Organism: Caenorhabditis elegans
Function: Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27528192}. Nucleus {ECO:0000269|PubMed:27528192}. Note=Mainly localizes to the nucleus during proteasomal disruption. {ECO:0000269|PubMed:27528192}.
Interaction partners:
- UV excision repair protein RAD23
- Polyubiquitin-A
- Ubiquitin-like domain-containing protein
- Ubiquitin-like domain-containing protein
- UBA domain-containing protein
- 26S proteasome non-ATPase regulatory subunit 4
- DUF2013 domain-containing protein
- 26S proteasome non-ATPase regulatory subunit 2
- OTU domain-containing protein
- Zf-tcix domain-containing protein
Sequence:
MSFQVSVAVNDGPFQKKSVTPNTTIGDLNNDAILIWKDTAIVYDISDESKNFGPTVTLEQLGVTQISMVYIYTTAFPCPSGDLRSIVPAQVRLISQFASAASSIFNGQSSSSAQSAQRTRRVEQDDEGEKSMFSRKLLDSPATFKALSENMFFRLKNEPHKLGYGLPELVERFLAKKDMTYKEFEQMFRSYVEEEVHKEEIIKNNPNSAEAKMFLEAKRNKELIDEQYLHSMTHHPEDMIAVTMLYINLTINGVPVKAFIDSGAQKSIMSMACAERCGLNGLIDRRFQSMARGVGGTEKIEGKIHLCDVKVEDAHFSCPFEVMARREMDLLIGLNVLRKHGCCINLKTSRLEFGNGTTTPFLQSNEIDSHLKEIMALPEEEMQFEDGST
Protein: C-type mannose receptor 2 (Endocytic receptor 180) (Macrophage mannose receptor 2) (CD antigen CD280) (Q4TU93)
Organism: Rattus norvegicus (Rat)
Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs) secreted by hepatic stellate cells. May mediate endocytosis of partially degraded collagens and glycoproteins produced in the extracellular matrix by MMPs.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Macrophage mannose receptor 1
- Secretory phospholipase A2 receptor
Sequence:
MGPIRPALAPWPRHLLRCVLLLGGLRLGHPADSAAALLEPDVFLIFSQGMQGCLEAQGVQVRVIPVCNASLPAQRWKWVSRNRLFNLGAMQCLGTGWPATNTTVSLGMYECDREALSLRWQCRTLGDQLSLLLGARANNASKPGTLERGDQTRSGHWNIYGSEEDLCARPYYEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPGEENCGVIRTESSGGWQNHDCSIALPYVCKKKPNATAEPIQPDRWANVKVECDPSWQPFQGHCYRLQAEKRSWQESKRACLRGGGDLLSIHSMTELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGRLSQGTAEEDHGCRKGWTWHSPSCYWLGEDQVIYSDARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFRWLSGDEVMYTHWNRDQPGYRRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWVSDPKLRHCYKVFSSERLQEKKSWIEALGVCRELGAQLLSLASYEEEHFVANMLNKIFGESEPENHEQHWFWIGLNRRDPREGHSWRWSDGLGFSYHNFARSQHDDDNIRGCAVLDLASLQWVAMQCQTQLDWICKIPRGVDVREPDIGRQGRLEWVRFQEAEYKFFEHHSSWAQAQRICTWFQAELTSVHSQAELDFLGQNMQKLSSDQEQHWWIGLHTSESDGRFRWSDGSVINFVSWAPGKPRPIGKDKKCVYMTARQEDWGDQRCHTALPYICKRSNSSGETRPHDLPPSTLGGCPSGWNQFLNKCFRIQGQDPQDRVKWSEAQFSCEQQEAQLVTIANPLEQAYITASLPNVTFDLWIGLHGSQRDFQWIEQEPLLYTNWAPGEPSGPSPAPSGTKPTSCAVILHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAAALPAPGTELSYLNRTFRLLQKPLRWKDALLLCESRNASLAHVPDPYTQAFLTQAARGLQAPLWIGLASEEGSRRYSWLSEEPLNYASWQDGEPQHTGGCAYVDVDGTWRTTSCDTKLQGAVCGVSRGPPPPRISYRGSCPQGLADSSWIPFREHCYSFHTELLLGHKEALQRCQRAGGTVLSILDEMENVFVWEHLQTAETQSRGAWLGMNFNPKGGMLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSSSGLWRPGACTNVTMGVVCKLPRVEENGFLPSAALPENPVALVVVLTAAVLLLLALLTGALILYRRRQSAERGSFEGARYSRSSRSGPAEATEKNILVSDMEMNEQQE
Protein: Pierisin (EC 2.4.2.-) (NAD--DNA ADP-ribosyltransferase) (Pierisin-2) (Pierisin-B) (Q9GV36)
Organism: Pieris brassicae (White butterfly) (Large white butterfly)
Function: ADP-ribosylates double-stranded DNA by targeting the N2 amino group of dG residues. Induces apoptosis in a range of human cell lines (By similarity). May play a role in destroying cells during pupation and/or defense against parasites (By similarity).
Interaction partners:
Sequence:
MSNNPPYMTNGIQAAVVEWIRALDLEIISLLLSRAWPLALLTTTELRWRPTVLTDTDNVVRLDRRQRLVRWDRRPPNEIFLEGFVPIVTREDPDWEETDLYGFAKNNHPSIFVSTTKTQRNKKKYVWTPRNANRGIVYQYEIYAPGGVDVNDSFSDASPWPNQMEVAFPGGIQNIYIRSARELHNGRVQRIWINPNFLDPGDLEPIVSSSRTLQVIWRVNHPDGGNKDGRSERSTSSYDDLMYGGTGNVQEDTFGDESNNPKPIADGEFMIESIKDKNSFLDLSKNVNGGIIHSNVYSGGDNQIWVFSYDDNKKAYKIKSYQNSSLYLSWDSNASSKEIILRGYTNSGSNNQYWQIEQTGKNYRLRNLLNLNMIITAQDKSSAFGGKEVIVNTEISNSNTKSSQEWNIIPFDFRPIMDGDYNIFNLDLPNQVVDFSNQPDLLVHGHEFCDNENQTWHFTYNSTYHAYKIWSGRKSNLLLTWDSNATSKEMVVRAYTESRSKNQYWRIEQTGSKSYKLRNLENSNMILGLTNVSTSYGGLNLMVQDDSNGNSNLHSDWDIKPIIYQYVPDGDYNIFNDNFPNIAVDYTNQEGALVHGHNFCSNNNQKWSFVYDGKKKAYKIKSGVNSKLWLTWDSNASSKEMVLRAYTESGNWNQYWRLYQANDGSYIIRNLKEFKMLIALTNIDTPYGGKQLIVTDTKESGNHWYLKKLGEVPLPNRKFRIATKLNYKKVIDSSTAYNLIITHDLNFASSIWELVYDSNKKAYNIYSADINNLGWVYQNKNFFVKLDNIDGPDHGDLRYFWTIEYSMQTGCYLIRSLYDPAHAVGYTDKDSVITDTSTYSDNQLFHFILM
Protein: Zinc finger (C2H2 type) family protein (O81793)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- C2H2 and C2HC zinc fingers superfamily protein
- C2H2-like zinc finger protein
- Uncharacterized protein
- C2H2-like zinc finger protein
- Uncharacterized protein
- Hydroxyproline-rich glycoprotein family protein
- Proline-rich family protein
- Protein NETWORKED 1D
- Zinc knuckle
- Protein indeterminate-domain 11
Sequence:
MSNPNPEKTKVDVTEEEKEESDEQWSDEETNMREIVLGLPALNISSRIFGESSSVVEEDAEKARLNEQAVLAAGLILAAAEEAVMKGMNEGSGSGGKKKSRPRISTQTDDEGDGLGEGEAKKPKKKAKELTHPPKGPPVCHICGRGFGSWKAVFGHMRAHRDRNYQGFLPPPTFSAGAERFVIPGLRSAFTIATVGGGSSGGVAVGGRSSGDFSGSGGGDAPGSEGGRGSGIDLNVEPVEQVEEATESGCIAKFDLNKSPPKDEEEEDKPK
Protein: Protein broad-minded (TBC1 domain family member 32) (Q5RHR6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for high-level Shh responses in the developing neural tube. Together with cdk20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
Subcellular location: Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Cilia- and flagella-associated protein 20
- Ubiquitin-conjugating enzyme E2 variant 3
- Sodium channel and clathrin linker 1
- ADP-ribosylation factor-like protein 2-binding protein
- Fumarylacetoacetate hydrolase domain-containing 2A.
- TBC1 domain family member 9B
- Cell division cycle 16 homolog
- WD repeat-containing and planar cell polarity effector protein fritz homolog
Sequence:
MSQFSTEDEAELQTLLRKLLKSVKDRISGAPSVECAEEILLHLEETDKNFHNYEFVKYLREYVESSLGAVIEVETENFTKGEGHAVGSGQDTLVHAVTKNTRESTQYKQMMQTLKQTMMMVVESLINKFEEDQMKREEMDRKIQHQQSISQYADNCSDSDSSFNQSYAFIKHEQLQVIAEKLDPGRPREVRWEALQSLCHAPPSDVLSCESWTGLRRNLSTALTDPDPELSDKVLQFFAKTFSSSPLNVTKDIYASIGNTKTLEAHFLYHKLSFPSGTTSIDANRPDMARLLKQMRLMNDFQKEVTTFWIRHPEKYMEEIIENTLSLLALHSEQGMSSPGSEKSLEPIHLISLLDIKATWFKKWMHGYYSRTVVLRLLERKYKSLIVNALQQCIYYFDSCDALSEETLEMIHSLEHQQIGPAGRTLYTSKELEFVYFVHSLCVLGRLVMYTNGRKFFPIKVKKRRDPVTLTDLVVILINIMYQHPKPSCGETALADTMSPTNLVMEVLRTLCDRTECAVECLYQIPVIETLLAPLITLLTGKLPKLNSMESALTHTADTLARIATTERGLSLLLYDRNLVSAEGESISAAHLIVQFTQKLLAKELQVENSSSMSGAFIFVCRQMYNTCEGLQVLRPYSLHECIAQAWRTTSSMSERVPTPVPGAPPALASQELQSVVAWEEMLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRCEKFGYGVMVTQVATTAPGIVALQSSGFVQTIVVELWSALECGREDVRVVHPKSTPMDPIDRSCLKSFLSLVNLLSSPHAVWELLGHRALPNKTEYNLREMATSVLDLMDRLIIINSDAKIHSLFNYEQSHTFGLRLLSVLCCNLDSFLLLESQYKLTDLLLQGQRDNVTEPPSGEGEFIIDGLSVERNHILVRICAVGGPSERKLPPRALQKGNDPYPWPMVSTYPLPKYYIFDVPKILRTKQESEIGAFLTSSKETERDASWMDDCRRQFCKIMATKSNTLTGYVLADLLEMVVLHLSSSSNDCFFPPAEYKVVDNSVKTRSLSSVEQLGVEISLRYGKFLKLLREDSEQDLCLLLKHCQEFLSQQRVKVTSELCGYPGHDWFASTVFLLMHGDVGRSLSLLLRFSRLLPSAFLWPPRLHSSVHLPIEIAQSAIHPIYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICVQWLGQCFWNYLDWPEICQYVTTCVIMGPDYQVYMCVSALRHLQQDILQHTQTQDLQVFLKEEPIQGFRVSNYLEYMEGLERSYRSMVLSDMRSILPRSS
Protein: Jasmonate O-methyltransferase (EC 2.1.1.141) (S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase) (Q9AR07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methylation of jasmonate into methyljasmonate, a plant volatile that acts as an important cellular regulator mediating diverse developmental processes and defense responses.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9SBK6}. Nucleus {ECO:0000250|UniProtKB:Q9SBK6}. Note=Predominantly cytoplasmic (By similarity). Partially nuclear (By similarity). {ECO:0000250|UniProtKB:Q9SBK6}.
Interaction partners:
- Allene oxide synthase, chloroplastic
- Allene oxide cyclase 4, chloroplastic
- Allene oxide cyclase 2, chloroplastic
- Allene oxide cyclase 3, chloroplastic
- 12-oxophytodienoate reductase 3
- Lipoxygenase 2, chloroplastic
- Lipoxygenase 3, chloroplastic
- Allene oxide cyclase 1, chloroplastic
- Lipoxygenase 4, chloroplastic
- 12-oxophytodienoate reductase 2
Sequence:
MEVMRVLHMNKGNGETSYAKNSTAQSNIISLGRRVMDEALKKLMMSNSEISSIGIADLGCSSGPNSLLSISNIVDTIHNLCPDLDRPVPELRVSLNDLPSNDFNYICASLPEFYDRVNNNKEGLGFGRGGGESCFVSAVPGSFYGRLFPRRSLHFVHSSSSLHWLSQVPCREAEKEDRTITADLENMGKIYISKTSPKSAHKAYALQFQTDFWVFLRSRSEELVPGGRMVLSFLGRRSLDPTTEESCYQWELLAQALMSMAKEGIIEEEKIDAFNAPYYAASSEELKMVIEKEGSFSIDRLEISPIDWEGGSISEESYDLVIRSKPEALASGRRVSNTIRAVVEPMLEPTFGENVMDELFERYAKIVGEYFYVSSPRYAIVILSLVRAG
Protein: Collagen alpha-4(IV) chain (Q29442)
Organism: Bos taurus (Bovine)
Function: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255|PROSITE-ProRule:PRU00736}. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Interaction partners:
- Collagen alpha-3
- Integrin subunit alpha 10
- Integrin alpha-3
- Integrin alpha-1
- Integrin alpha-6
- Integrin beta
- Integrin subunit alpha 4
- Integrin beta
- Integrin alpha-2
- Integrin beta
Sequence:
GPPGPPGAPGKALKGDIPDPGLPGDQGPPGPDGPRGVPGPPGPPGSVDLLKGEPGDCGLPGPPGLPGPPGPPGHKGFPGCDGKHGQKGPMGFPGPQGPPGSPGPPGDKGLPGPPGRRGPLGPPGSRGEPGPPADLDACPRIPGLPGVPGPRGPEGTMGLPGMRGPPGPGCKGEPGLDGRRGEDGLPGSPGPPGHKGDMGEAGCPGAPGPPGPMGDPGPIGFGPGYLSGFLLVLHSQTDGEPTCPMGMPRLWTGYSLLYLEGQERAHNQDLGLAGSCLPIFSTLPFAYCNIHQVCHYARRNDRSYWLASTAPLPMTPLSEDEIRPYISRCAVCEAPAQAVAVHSQDQSIPPCPRAWRSLWIGYSFLMHTGAGDQGGGQALMSPGSCLEDFRAAPFLECQGRQGTCHFFANKYSFWLTTVRPDLQFSSAPLPDTLKESHAQRQKISRCQVCVKHS
Protein: Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein homolog) (Q9D7E3)
Organism: Mus musculus (Mouse)
Interaction partners:
- 2-
Sequence:
MAARQTLRVLCLAGFRQSERGFREKTGALRKTLRGRAELVCLSGPHPVPEAAAPEGSCPDSGPCSPEEQPRGWWFSEEEADVFSALEESTVCRGLQEALETVARALDTLGPFDGLLGFSQGAALAAYVCALGQAGDPRFPLPRFIILVSGFCPRGLKEPILQSPMSLPSLHVFGDTDRVIPSQESMQLASRFLGAVTLTHSGGHFIPAAASQRQAYLKFLDQFAE
Protein: MYB-like DNA-binding domain protein (O49017)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAPKKAGVSKRVFNKGSWTAEEDRRLAKYIEIHGAKRWKTIAIKSGLNRCGKSCRLRWLNYLRPNIKRGNISDEEEDLIIRLHKLLGNRWSLIAGRLPGRTDNEIKNYWNSHLSKKMINHDVRTEQTSSSEQIVPHKAWETVQMEEEEVVKGSDEIENSEFSIDVDEFFDFSTEGCFGLDWVNKFLELDDQQDPLAMV
Protein: Serine/threonine-protein phosphatase PP1-beta (EC 3.1.3.16) (CeGLC-7-beta) (Glc seven-like phosphatase 2) (P48727)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA-mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Promotes small RNA-mediated genome silencing over multiple generations. Essential for embryogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12837290}. Nucleus {ECO:0000269|PubMed:12837290, ECO:0000269|PubMed:30921322}. Note=Localizes to nuclei in the mid-pachytene to diplotene phase of meiosis. {ECO:0000269|PubMed:30921322}.
Interaction partners:
- Long arms of the bivalent protein 1
- RNA polymerase II subunit A C-terminal domain phosphatase ssup-72
- Protein phosphatase 1 regulatory subunit SDS22 homolog
- pre-mRNA 3' end processing protein pfs-2
- WD_REPEATS_REGION domain-containing protein
- Aurora/IPL1-related protein kinase 2
- Cleavage and polyadenylation specificity factor subunit 3
- Probable cleavage and polyadenylation specificity factor subunit 2
- Protein phosphatase inhibitor 2
- Probable cleavage and polyadenylation specificity factor subunit 1
Sequence:
MDVEKLNLDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKKKYPYGAGGVGSNRPVTPPRNAPAAQPKKGAKK
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (EC 2.7.11.26) (EC 2.7.11.31) (Acetyl-CoA carboxylase kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (Tau-protein kinase PRKAA1) (W5PHS9)
Organism: Ovis aries (Sheep)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRACQRNDSDAEAQGKSSEASLTSSVTSLDSSPVELTPRPGSHTIEFFEMCANLIKILAQ
Protein: PH-sensitive chloride channel 1, isoform O (M9PCN5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGCVFEAAKEQPHKPRSRQLRRNQCRGKAEKAAAGTRGKVAVRGNNDKPAEDIKIKDNYQQNHKTQTETQTEVAAVVAIATDAGAETETETEAEAQKEPATGPEHLKAAAQVLLTIRQARQENNKHSSSQVAETHKDEGEDALARQGSIVDTAAGRIGIDIAATTIQVAERHEDGQHWQQHNVRRRRRQPDPAAHPASITKLSAISLHFHALAALAKTLQKHEDLSPVQDRQPLAYRAWQEHPYAETQMPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTAAATQSETGALDKHPIFDESSSDKEILDLLLEKKRYDKRLLPPVNGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTACDQNSWRGNYSCLRVDLIFTRDRAFYFTTVFIPGIILVTSSFITFWLEWNAVPARSMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIEAEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHYKGFS
Protein: 5'-3' exonuclease XRNC, putative (Q57W91)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 5'-3' exoribonuclease 2
- 5'-3' exoribonuclease 2
Sequence:
MGVPLLLTWLRRRFAACFLPSNSNVSADCLYIDVNGLVYQAATLATSGGGDPADIEAAILRRLFDLLDDIVLRLVRPRSLVYLAVDGISPMGKLAQQRSRRRRRRRQDPHSHVRTTEWDSNSISVGTSFMSSLTDALHFYCASRAERINVERLREYKQRDVGKDVASAGFPANEKAAPSLITFVSDNVWRPGEGESKIADAIRRFRSQPSYDPNTAHVICSSDTDVTVCSLILHEPNIHVLRYEHVSASTAKGGNNNWQTYAGDSWASTFFSIYAFREELRLRLRIEQTRSNTMSAEELEKLNKQFEAALHDVVFVLLLFGNDFLPSVGCRIEEGFLDSLLEMLATDFVTRGRSIVDPVTNTIQFDAARYALESLAEMRNERSSGLQVDNGAEGAADWGFVNEQFLQRKAAEEAEKAPWCYAYWTMLQWSLQNSAGVVEHWGCYYPYSTAPPLHLLQKYCGTLSYDALMELAEKRSRRKVGHHNRAHDGTNSGSGERGVRLRGPGPTDVLVQLLVLLPTRSIALLPTAVRKGYSEIEPIVVAPVEEIDFAAVQTWCATKRGLFTEEERVRFDAYALAASDHLVAGDVHAKCVRGNEMLFVADWNAEELAAELRELEEIVQGGGGTRSDGSSSSKKQTDTLNSATGVFTSFFSARNAGKTSAAVAALLSAPKFSRNIGEGGTGNADTVTTSSGIPNINGTSNNTDRDVLQQSIDVDVLSAANFTFHTVSTSALKGESMVRRVGNITGDTFECGSYSVGPLSRNQKTMRVRLRWRVASRPPRDAAPFLPYLLSGLKPRQKSAEGDGTAGKEGVKRPRSEVAKSAGDDDAKKNVFDDFTQQTMLHDTLQEKKEALRRRLEALQGGNATLGT
Protein: LD09043p (Q95RV8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLCDECNAGTHMFCLKPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHENEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLPFRPSDMNGEVKAC
Protein: Metallothionein-3 (MT-3) (Metallothionein C) (Q9VDN2)
Organism: Drosophila melanogaster (Fruit fly)
Function: This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity).
Interaction partners:
- GEO10380p1
- Metal response element-binding transcription Factor-1, isoform C
- Metallothionein-1
Sequence:
MVCKGCGTNCKCQDTKCGDNCACNQDCKCVCKNGPKDQCCKSK
Protein: Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (P47727)
Organism: Rattus norvegicus (Rat)
Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q28960}.
Interaction partners:
- Carbonyl reductase 2
- aldose reductase
- Aldo-keto reductase family 1 member B1
- Cytochrome P450 1A1
- Prostaglandin E synthase
- Dihydrofolate reductase
- Prostaglandin E synthase 3
- Cytochrome P450 2E1
- Aldo-keto reductase family 1 member C15
- UDP-glucuronosyltransferase
Sequence:
MSSDRPVALVTGANKGIGFAIVRDLCRKFLGDVVLTARDESRGHEAVKQLQTEGLSPRFHQLDIDNPQSIRALRDFLLQEYGGLNVLVNNAGIAFKVVDPTPFHIQAEVTMKTNFFGTQDVCKELLPIIKPQGRVVNVSSSVSLRALKSCSPELQQKFRSETITEEELVGLMNKFIEDAKKGVHAKEGWPNSAYGVTKIGVTVLSRIYARKLNEERREDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPGAEGPHGQFVQDKKVEPW
Protein: Endoribonuclease Dicer homolog 1 (Dicer-like protein 1) (OsDCL1) (EC 3.1.26.-) (Q8LMR2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the RNA silencing pathway. Cleaves double-stranded RNA to produce microRNAs (miRNAs) of 21-24 nucleotides which target the selective destruction of complementary RNAs. Regulates by this way the development of the plant. May not be involved in small interfering RNAs (siRNAs) production.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein argonaute 7
- Large ribosomal subunit protein bL27c
- Protein argonaute 1C
- Os01g0220300 protein
- Large ribosomal subunit protein mL46
- Protein argonaute 2
- Large ribosomal subunit protein bL33c
- Os07g0658200 protein
- Small ribosomal subunit protein uS9c
- Protein argonaute 16
Sequence:
MAGGGGVGGGAGEHAAAAYWYDACEDGASLLCGIDFAASADFDPGLIPAMDTGADDGFVAEIDRILESINAESSPAPPPPPPPPLPEPVPVAPPELPIQEKQLQVASAPVANNAVAVVGVVQRSKGVVARKEPRRESHGCAANGGGGGEWRDGKRPRLASGGVGGPRQEWRRRPMLPPPPSRGWDDRRGRRDFDRVRKHEHHRREARGFWERDRGGKMVFRSGTWEQESDREAKRARTQDGGSMEKKAEADRMGAAQREKPVAEERARQYQLEVLEQAKSRNTIAFLETGAGKTLIAVLLIKSVCDKMLKENKKMLAVFLVPKVPLVYQVLVMTAQILLNILRHSIIKMDAIHLLILDECHHAVKKHPYSLVMSEFYHTTPKEKRPAVFGMTASPVNLKGVTSQEDCAIKIRNLESKLDSVVCTIKDRKELEKHVPMPLEVVVQYDKAATLWSLHEQIKQMESTVEEAALSSSKRTKWQFMGARDAGSRDELRLVYGVSERTESDGAANLIQKLRAINYALGELGQWCAYKVAQSFLTALQNDERANYQVDVKFQESYLKKVVDLLHCQLTEGAAMKSETSDVEMQNTEKHNTNDLEEGELPDSHGEHVDEVIGAAVADGKVTPRVQALIKILLKYQHTEDFRAIIFVERVVTALVLPKVLAELPSLSFIRCASLIGHNNNQEMRACQMQDTISKFRDGRVTLLVATSVAEEGLDIRQCNVVIRFDLAKTVLAYIQSRGRARKPGSDYILMLERGNISHETFLRNARNSEETLRKEAMERTDLSHLDGTSVLSPVDTSPGSMYQVESTGAVVSLNSAVGLIHFYCSQLPSDRYSILHPEFIMQKYEKPGGSVEYSCKLQLPCNAPFEKLEGPICSSIRLAQQAVCLAACKKLHEMGAFTDTLLPDRGSGEGEKTEQNDEGEPLPGTARHREFYPEGVADILRGEWILSGRDGYQNSQFIKLYMYSVNCVNVGTSKDPFVTQLSNFAIIFGNELDAEVLSTTMDLFVARTMITKASLVFRGRIEITESQLVLLKSFHVRLMSIVLDVDVDPSTTPWDPAKAYLFVPVGAEKCTDPLREIDWTLVNNIVNTDAWNNPLQRARPDVYLGTNERTLGGDRREYGFGKLRHGTAFGQKAHPTYGIRGAIAEFDIVKASGLVPARDRGHFSDYQNQGKLFMADSCWNAKDLAGMVVTAAHSGKRFYVDCICYNMNAENSFPRKEGYLGPLEYSSYADYYKQKYGVELIYRKQPLIRARGVSYCKNLLSPRFEHSDAREGDFSENLDKTYYVYLPPELCLVHPLPGSLVRGAQRLPSIMRRVESMLLAVQLKDIIDYPVPATKILEALTAASCQETLCYERAELLGDAYLKWVVSRFLFLKYPQKHEGQLTRMRQQMVSNMVLYQYALNKTLQSYIQADRFAPSRWAAPGVLPVFDEESREYEPSIFDEESTGCELQKESYDDYADNMQEDGEIEGDSSCYRVLSSKTLADVVEALIGVYYVAGGKIAANHLMKWIGIHAELDPEEIPPPKPYDIPESIMRSINFDTLKGVLGIEFQNKGLLVEAITHASRPSSGVSCYQRLEFVGDAVLDHLITRHLFFTYTDLPPGRLTDLRAAAVNNENFARVAVKHKLHVHLRHGSSALETQIREFVKDVQEELLKPGFNSFGLGDCKAPKVLGDIVESIAGAIFLDSGYDTSVVWKVFQPLLHPMVTPETLPMHPVRELQERCQQQAEGLEYKASRAGNIATVEVFVDGVQIGVAQNPQKKMAQKLAARNALVVLKEKETATKKEDERDGEKKNGAQMFTRQTLNDICLRRQWPMPQYRCVNEGGPAHAKRFVYSVRVNTSDRGWTDECIGEPMPSVKKAKDSAAVLLLELLNRDFPDKPDGKQP