wanglab/gogpt-training-data huggingface dataset:
Protein: F-box/LRR-repeat protein 15 (Q6NW95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway (By similarity). Required for dorsal/ventral pattern formation.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- Cullin 1b
- F-box only protein 33
- F-box only protein 11
- F-box only protein 2
- E3 ubiquitin-protein ligase RBX1
- F-box and WD repeat domain-containing 10
- F-box/SPRY domain-containing protein 1
- F-box and WD repeat domain-containing 2.
Sequence:
MDQKPDERVQSHRCELLDLPWEDVLVSHVFCHLPLRLLVSLQRVSKSFRSLIQVYLDNCRTFDPAQTGPHIPREAFCSILRHNQVLQHLSVTNCSDWITDTDLLPVIGQNQQLQHVDLRGCAQLSRRALVAVSLSCPRLQHLSLAHCEWVDSLALRSLADHCPMLRSLDLTACRQLKDPAVCYLAGKCPELRALSVAVNANITDTAVEEVAKKCREMERLDLTGCLRVRNEAIRTLAEYCPKLQSLKVNHCHNVTESSLGVLRRRNVEIDVEPPLQRALVLLQDVVGFAPFINLQI
Protein: UDP-glycosyltransferase 78D3 (EC 2.4.1.-) (Q9LFK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses low quercetin 3-O-glucosyltransferase activity in vitro.
Interaction partners:
- Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1
- UTP--glucose-1-phosphate uridylyltransferase 3, chloroplastic
Sequence:
MAKPSQPTRDSHVAVLVFPFGTHAAPLLAVTCRLATAAPSTVFSFFSTARSNSSLLSSDIPTNIRVHNVDDGVPEGFVLTGNPQHAVELFLEAAPEIFRREIKAAETEVGRKFKCILTDAFLWLAAETAAAEMKASWVAYYGGGATSLTAHLYTDAIRENVGVKEVGERMEETIGFISGMEKIRVKDTQEGVVFGNLDSVFSKTLHQMGLALPRATAVFINSFEELDPTFTNDFRSEFKRYLNIGPLALLSSPSQTSTLVHDPHGCLAWIEKRSTASVAYIAFGRVATPPPVELVAIAQGLESSKVPFVWSLQEMKMTHLPEGFLDRTREQGMVVPWAPQVELLNHEAMGVFVSHGGWNSVLESVSAGVPMICRPIFGDHAINARSVEAVWEIGVTISSGVFTKDGFEESLDRVLVQDDGKKMKVNAKKLEELAQEAVSTKGSSFENFGGLLDEVVNFG
Protein: bZIP transcription factor RISBZ1 (Rice seed bZIP1) (bZIP transcription factor 58) (OsbZIP58) (Q6ZLB0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional activator that binds to the DNA specific sequence 5'-TGAGTCA-3' found in seed storage protein gene promoters. Involved in the endosperm-specific regulation of storage protein genes. Can activate the expression of genes encoding for the seed storage proteins glutelin, prolamin, globulin and the allergen RAG1. Functions synergistically with DOF3/RPBF to positively regulate quantitatively many seed storage protein genes. Functions synergistically with DOF3/RPBF to positively regulate some metabolic enzymes, such as alanine aminotransferase and pyruvate phosphate dikinase, that are expressed in developing seeds. Functions synergistically with DOF3/RPBF to positively regulate genes that are key players in the development of aleurone layers. Functions synergistically with DOF3/RPBF to positively regulate the glutelin GLUD-1 gene in endosperm of developing seeds. Can activate the expression of the bifunctional lysine-degrading enzyme, lysine ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH), one of the key regulators determining free lysine content in plants. Functions as a key regulator of starch synthesis in seeds, by direct binding to the promoters of starch-synthesizing genes, such as AGPL3, WAXXY and SBE1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:19473328}.
Interaction partners:
- Transcription factor HY5
- Os02g0202950 protein
- Os01g0587900 protein
- Transcription factor HY5
- Transcription factor HY5
- bZIP transcription factor 60
- bZIP transcription factor 39
- protein-serine/threonine phosphatase
- Os07g0692800 protein.
- Eukaryotic translation initiation factor 2 alpha subunit family protein, expressed
Sequence:
MEHVFAVDEIPDPLWAPPPPVQPAAAAGVDDVGAVSGGGLLERCPSGWNLERFLEELDGVPAPAASPDGAAIYPSPMPAAAAEAAARWSRGYGDREAVGVMPMPAAALPAAPASAAMDPVEYNAMLKRKLDEDLATVAMWRASGAIHSESPLGNKTSLSIVGSILSSQKCIEGNGILVQTKLSPGPNGGSGPYVNQNTDAHAKQATSGSSREPSPSEDDDMEGDAEAMGNMILDEEDKVKKRKESNRESARRSRSRKAARLKDLEEQVSLLRVENSSLLRRLADANQKYSAAAIDNRVLMADIEALRAKVRMAEESVKMVTGARQLHQAIPDMQSPLNVNSDASVPIQNNNPMNYFSNANNAGVNSFMHQVSPAFQIVDSVEKIDPTDPVQLQQQQMASLQHLQNRACGGGASSNEYTAWGSSLMDANELVNMELQ
Protein: Uncharacterized protein (Q38AM6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAVDCLAGEWMRYVREWLQQHDFSKKNSGVGGLTYTDLLNLLQDGPPAPPSLCATWEKRVWNLQDEPLALYYLRCLASSFENVYSFSECAFLISATSSSPFPRLPHGSDIHGVLHRRPIRVVALRLLPTTTDIVQLGWRGTDFVSSSTERLQPALCSRTHFVIQLLDSMRHFSAWAYGDVGTQMRLGDVLCAVMYASSMDDGSTAYVIHNTERCSDVEWVMRPMLATAEVTRDPFSLVSATPPLTFKQLTRAFAPEIAGQELCKSMLLLVATHTIYRSLRCRSRRPLHLLLLGPSRSGKSALLRAFLHFLGSCATLVGAHVMRGGQRSTVASQAITAAYPHVHQQLLMAGAVSAVDSLVIDELPANGSGAFTNHVGGLLCGLCPINSGGGSGTGGAATLRGGVVRTRAQITAASNDDNLGIAAIVPQFTLVARTTANLLLQNAALVGDEVIAASVARSQSKSAPRSRSTSLGSSRVSMCHGPLSSATLHIIVKEAPCAASLEAAIPVNEFTAFYLSRLSERCQYGVTECEKTFGSHLVVLWELNIARLILNGICNVEAEAQSGDCRRACVAGWNETLAEEVWLCYKHHLWTADTAASASSTTLQSAVSVATTSAGLSSLDHFVSEGPVYGPASRSAAGAHKRKRVGKKAACLVLLRQMLAEQRACNGSAVPEEVVRCLFERMGGEHHIGMCLSSVIQQLLDAGLIIRRLNAYAVVAEV
Protein: RNA-binding (RRM/RBD/RNP motifs) family protein (T4P13.10 protein) (Q9MAD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MYPCGYVAQVTNLSPQATEKDVHRFFSHCGIVELVEITGCQGDALTAYVTFRDAYALDMAVLLSGATIVDQTVWISVYGVYLHESNNLRQEEDYSVTVTRSDAFASSPGEAITVAQQVVQTMLAKGYVLSKDAIGKAKALDESQRFSSLVATKLAEISHYLGLTQNIQSSMELVRSADEKYHFSDFTKSAVLVTGTAAVAAATITGKVAAAAATSVVNSRYFANGALWFSDALGRAAKAAAHIGGGGSN
Protein: Natalisin, isoform D (E2QD54)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Trissin
- Adipokinetic hormone
- Cardioactive peptide
- Tachykinin-like peptides receptor 86C
- Tachykinin-like peptides receptor 99D
Sequence:
MRLTLAWLSLCLAIYCGGGHGHGNVVLSLPPSLIATATKAALSHQRQQKQQQQHQKKDARVLFDSPADALRDMMHNGNGNGNGPMDSGKFSLSDVEQPAAQRSEDFNRNAYDLGARQSAPQEIAMGMELGMGLGLGPNNYRTTPPHRYWGQRCQGRSGGSGTSKCPQEYYRTMLAARNKEALSRLHMQLSSMQDSDSGASSSSDSEEEHVDDEEQSNNEVFMLLTGEQDLMKFLHWAMQVLYPIERPLGNLSDGAAENYYPGMFLWKKLNLSGHLEPPLIVDEPQYVLVRREKLFDGYQFGEDMSKENDPFIPPRGRKHSGSLDLDALMNRYEPFVPNRGKRDKVKDLFKYDDLFYPHRGKKHRNLFQVDDPFFATRGKKLQLRDLYNADDPFVPNRGKRHLTASAGKLGETMAGGGKWPDDSNNYWPLRMSTHKINGYDQSVRPSLSVEDAAASLASWRLPANRLHSTRSMSADLRQQLLLPHVRFIGNPNMRQQQQQQQQHQVKTSSWQAEERLRRSILAPGESNDAHETQLTLSHPANPHLVTDTDNLNI
Protein: Homeobox protein MSX-1a (Homeodomain protein MsxE) (Q90455)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MAPVVTMSSQAAEEDAGVMLAGQTEMQTRVTVQEDAQRPKILPFSVEALMADRRPNRGSPDADARLGFSVEVLQLPVKAESPERSTWVPRARFSPSRLSPPACPLRKHKTNRKPRTPFSTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPLLPPAFGISFPAGAHIPAYSAGSHPFHRHSANVSPVGLYTHMGYSMYHLA
Protein: Protein CLEC16A (Q80U30)
Organism: Mus musculus (Mouse)
Function: Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:24949970}; Peripheral membrane protein {ECO:0000269|PubMed:24949970}. Lysosome membrane {ECO:0000269|PubMed:24949970}; Peripheral membrane protein {ECO:0000269|PubMed:24949970}. Note=Associates with the endolysosome membrane. {ECO:0000269|PubMed:24949970}.
Interaction partners:
- E3 ubiquitin-protein ligase NRDP1
- Dexamethasone-induced protein
- GPN-loop GTPase 1
Sequence:
MFGRSRSWVGGGHSKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENPDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYTKPAQDVPRSSAKPSIRCFIKPTETLERSLEMNKHKGKKRMQKRPNYKNVGEEEDEERGSAEDAQEDAEKTKEIEMVIMKLGKLSEVAAAGTSVQEQNTTDEEKSAATNSENAQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPVPSEAEKTTYNHLLAERLIRIMNNAAQPDGRIRLATLELSCLLLKQQVLTSSGCVIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLCSSSSSSQHLPFRFYEQCRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSPSPPFASGSPGGSGSTSHCDSGGSSSAPSATQSPADAPTTPEQPQPHLDQSVIGNEMDVNSKPSKNSSARSSEGETMHLSPSLLPAQQPTISLLYEDTADTLSVESLTIVPPVDPHSLRALSGISQLPTLPAADTETPAEGAVNPEPAEPTEH
Protein: Uncharacterized protein (Q38BP8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLFTCSSRRLVGRTLTLYLLRRNCSALTASVSRTVPSDESVATSGGRIVSAAPAPNLARKETQRKQVRRSKPSTAATAKGESTGEEGTESVEHILSLVSASQVRACIESHEPEVSSSFAASPQTPVTQALQLHRRLASEKQQPHIGIGETTVSSSASIASERVERRRKKWTVAESEFDAGITERLLPEIRRLAALHELHYGDAVMREVDSSTYFASLGGATASVADMRADDDINDADLTDDEFLKFEAEQVEVAGGPVLYNTSSSGIIEKCQKKEEITNAANDEEKVCAHSLQTPWFVPAGGVVRLEPLPPEDVLCLLKFLMHLRQQTLDQLPVPLQAKVSATERVLRSVHQEEKSKEIPIVPRAVADGGTTCISFEDVMVYLDKAPSPILGFTENLPPGESPAFVFVLYTENVSLQNAIGHMSALFEIPQRAFLTCTAVSKMSCGAVLCAVTPNQVRREHLLLLNTMRHPGFVIRVGSIQEVKDAERIASLFGDLARWQPLHEVEVLLRRVSCRSRQELEHRLRAIKEVGAVFFCSNREASLVRAATDLLHGFYRSALLSALHRRHAPLELRQFIKRPNVITAARARRASTDPTIRQALKNYELTQGNWEQTVARIPYVWRRRWLNALRSSVWNVMASRRLSLDGASRRVIPGDIVFRPEYRADVHHRMIPTVKAEHVMVVRDEEEAALCSVEDICIPFLRGTYPPELFAPEETKHPIMTNTSMLAILRELHAPQLLLGMNDACRQLMDIRCDCAPLLFRRLIIRPIAVSFTVLEDKPPVKSVHFDAARLLLNDRLMHQNALRRNPLQKSDPSKRCGVGADGEASLPSCSSLANQDVVLDQTTIGARLMSGVLAEEFFTTPDRSDYVTLGHVTRKLHGNFVAAAPQTPEDALGTVDRLYSVHIHAVLRYGVGAMSQLLREYFILGGVEAESDSALQHKVHRMRRELDNETQYLTAPTFCTACYSRCHDALNSCAEYQHKHGKHLGRKRREETLQQLQFMGKTLPSVADTSPLSSREAATVPGGGEISAVSGVNGSAVETQQTTKGVTNASHTQLELELLLRRRNGEQKWGVHLTSSLCLANIDDVSVVAGGRLRCVCGDVTSAISPKQLCRVLLQGSVEDISSTSNEINKHHMLALRRFVAVSTGEKVDTIYESSNKTWDNGCEAASILDENSDGVKLTKVAEVFSVSSPRHPQTLTTESRGEIDTVVGDSRTLLHNCRWALKGINDAEVADRKQVAAVFVTIGKQREVRLRFRTTIDLPLSHINEHGNDSNNAGGTERCELPAVAELTLSIAEGNGSCGKSGWGVMIDKSSLALLNLSELLQQRQVGVSGRLNPPIPSYINPSAADGMYVLHALDGIPVASQQEVSLHMGKRRQALKGVSNGKCSSLRLQLRRLQGHPQKGVATVETAKLPGATMKTIVAAGVEADGKRDKVTTVVNSTTTVEDVSDAAESESGLTPLLPCSPQCVPLTSVQLRRSVFTIAINRSAGAPRGRWGIRVQRGTRRLQYIQHNQYFTFQVYTAKQNQAVRIADNLRLHTHQLKSSGTSEPDDGTVASETEEKERTTAASFSYFIYMIAGVNYRHVGTNEELRASLTEAGRSHEESVILHVQQYRLAYIALSVKRKEVAGGGALEPVGLCISKDMVIKSVVAGSAVARAIIAATHEDCSLRGLIVEDPSSSGGNFSSPNQTWRFDLDEDEEGQHIQTNSPVGDAGARNVPGNSNSDAVLGRRVAHWNMVDGVALCATHDKVESSAGGESRNRFVWRILYAARAGPLRTPQDVARTFASNIQEDTIFVQQCVMDD
Protein: KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) (Q7Z3B3)
Organism: Homo sapiens (Human)
Function: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:20018852}. Nucleus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Mitochondrion {ECO:0000269|PubMed:27768893}.
Interaction partners:
- PHD finger protein 20
- WD repeat-containing protein 5
- KAT8 regulatory NSL complex subunit 2
- Microspherule protein 1
- Histone acetyltransferase KAT8
- KAT8 regulatory NSL complex subunit 3
- Host cell factor 1
- Retinoblastoma-binding protein 5
- Histone-lysine N-methyltransferase 2A
- Chromodomain-helicase-DNA-binding protein 8
Sequence:
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGKRALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGAPIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCVAARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAERLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR
Protein: Flavin-dependent monooxygenase, oxygenase subunit HsaA (EC 1.14.14.12) (3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit) (3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase) (P9WJA1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Can also use 3,17-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one (3,17-DHSA), but it has higher specificity for 3-HSA than for 3,17-DHSA. Can use either FADH(2) or FMNH(2) as flavin cosubstrate. Also catalyzes the o-hydroxylation of a range of p-substituted phenols to generate the corresponding catechols.
Interaction partners:
- Iron-dependent extradiol dioxygenase
- Flavin-dependent monooxygenase, reductase subunit HsaB-triene-9,17-dione 4-hydroxylase, reductase subunit)
- 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1
- 3-ketosteroid-9-alpha-monooxygenase, oxygenase component
- 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
- 3-oxosteroid 1-dehydrogenase
- (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase (HIEC-CoA hydrolase)
- 4-hydroxy-2-oxohexanoate aldolase
- 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase beta subunit
- HTH-type transcriptional repressor KstR
Sequence:
MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV
Protein: Transcription factor bye1 (Q9Y7V2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Negative regulator of transcription elongation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00651, ECO:0000269|PubMed:10759889}.
Interaction partners:
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Sister chromatid cohesion protein mis4
- DNA-directed RNA polymerase II subunit RPB3
- Transcription elongation factor S-II
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit rpb7
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MVRKSTRRTAKASEKPPETVVRCVCKSQEDIGDTWVQCDGCDCWQHASCVGLADKDIPESYYCEVCHSRSDVSSQVQNSPNKDEEHQTADLLASNEGNEKNNEENNVVSSDSKEAITKESGAELESSEPASTNSNVGMTTRSGRQSPRTPIGSTTPKSSHSPPSTRKRRGSVGTTATHTKRSKNAPKTSPKDASNETADQEKELSLHTSIDEIQNPVRKSVAKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVLSYTTDHSLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFNDLVNLSSEEMANPDLKNLAEEIRQQSTENTVIKQHLIAPRDRLLDEDKLTQQDELGIAENDDAMFPKPPGELVAPISIAEEEPTIDSKSPTLPEHNPLSEDDTSNGDKAAKRKGSFNDTKPIVNVPSIVEIDDPTILDIVEEEPLARNDSFSSPYSPAEDMAEESEFFGMKEKIWTGKVKMATVSEFHANALNLFGDVSASHLFEILSATALIEGRISVSSVLQYFHALRKTPSKEIIAVLFVPTEQNSQGFDILYDYFVKRNRYGVLHSKSNSVKDAYIIPMPSGNSVPELLDLLPKVDLPKDRNFQYFMGLFVLNKSSSRHESVERATPITTSTNGIPSTYQSASGTPTNPVHSYPSLESIINALTPSDMLLIKDVVENNPQIRANPSLAINPQFMQNAISAAQKKASKQ
Protein: Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) (Q86SJ2)
Organism: Homo sapiens (Human)
Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST
Protein: Anaplasma Translocated Substrate 1 (Ats-1) (Q2GJL5)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
- HIT family protein
Sequence:
MLIRRILTTSRNVAARIVSGFTAPATENTSARTSRNLLGTTGNFFNGLMGKGKPFYHRASEMQNLPWDKERGTKISSHYAQTGQLVLQIGDGRVSEGALQMLEALDNSDVGELDPSSKGLNPGMDIGARMDHNRAKNECGALLDLRKKLEETGGKISVERTGDGFTRMLVIKIDTKNKSEEEVEKEVQLVLGTLGVGSKILAKSIAKELMHQAKTKDMNALAPVSHTPPAQSKPDSDIQENSEKSASADAKNRSQAPDQEENSPRDTTRRNSTTNGEERIFSLSGDASPSRPSSGAGTDQAVQQAHFLRDSEDRVHGSSGITNQGAAAMQQAVLSAARGLSDVSHDDSAQTQGNPTVTPLVSAQNRGPETHGKGTR
Protein: Protocadherin 9 (A0A0A6YWM0)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNENFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKALHTLVLVFLYVNDTAGNTSYIYDLIRRTMETPLDRNIGDSGQPYQNEDYLTIMIAIVAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKK
Protein: Nitrogen regulatory protein (Enzyme IIA-NTR) (PTS system EIIA component) (Phosphotransferase enzyme IIA component) (P69829)
Organism: Escherichia coli (strain K12)
Function: Seems to have a role in regulating nitrogen assimilation.
Subcellular location: Cytoplasm.
Interaction partners:
- Phosphocarrier protein NPr
- RNA polymerase sigma-54 factor
- Ribosome hibernation promoting factor
- Phosphoenolpyruvate-dependent phosphotransferase system
- RNase adapter protein RapZ
- Ribosome-associated inhibitor A
- Sensor protein KdpD
- Ribulose-phosphate 3-epimerase
- DNA topoisomerase 4 subunit A
- Cell division topological specificity factor
Sequence:
MTNNDTTLQLSSVLNRECTRSRVHCQSKKRALEIISELAAKQLSLPPQVVFEAILTREKMGSTGIGNGIAIPHGKLEEDTLRAVGVFVQLETPIAFDAIDNQPVDLLFALLVPADQTKTHLHTLSLVAKRLADKTICRRLRAAQSDEELYQIITDTEGTPDEA
Protein: Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef) (Q8NFM7)
Organism: Homo sapiens (Human)
Function: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Cell membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Interaction partners:
- Interleukin-17 receptor C
- Interleukin-17 receptor A
- Interleukin-17 receptor B
- Interleukin-17 receptor E
- Protein sprouty homolog 4
- Interleukin-17B
- Interleukin-17C
- Interleukin-17F
- Interleukin-17D
- Interleukin-25
Sequence:
MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYFVKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYKLKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDTNTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESSESSTYTAALPRERLRPRPKVFLCYSSKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNYKHKGGGRGSGKGELFLVAVSAIAEKLRQAKQSSSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFVPFHPPPLRYREPVLEKFDSGLVLNDVMCKPGPESDFCLKVEAAVLGATGPADSQHESQHGGLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPRDSGIYDSSVPSSELSLPLMEGLSTDQTETSSLTESVSSSSGLGEEEPPALPSKLLSSGSCKADLGCRSYTDELHAVAPL
Protein: F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) (Q9BQ87)
Organism: Homo sapiens (Human)
Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:30341416}.
Interaction partners:
- F-box-like/WD repeat-containing protein TBL1XR1
- G protein pathway suppressor 2
- Histone deacetylase 3
- Nuclear receptor corepressor 1
- Catenin beta-1
- Nuclear receptor corepressor 2
- Putative serine/threonine-protein kinase PRKY
- F-box-like/WD repeat-containing protein TBL1X
- Amelogenin, Y isoform
- S-phase kinase-associated protein 1
Sequence:
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL