wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) (P59923)
Organism: Homo sapiens (Human)
Function: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance.
Subcellular location: Nucleus {ECO:0000269|PubMed:30602440}. Note=Binds various differentially methylated regions (DMR). {ECO:0000269|PubMed:30602440}.
Interaction partners:
- Transcription intermediary factor 1-beta
- Zinc finger protein 396
Sequence:
MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQTLNRPGQELFRQLFRQLRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQETMTFKDVEVTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGPFTKPALISWLEAREPWGLNMQAAQPKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHTGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARHMKNHIRD
Protein: Opacity protein opA67 (Q05034)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
Interaction partners:
Sequence:
ASEGNGRGPYVQADLAYAAERITHDYPEATAQKKGTTISTVSDYFRNIRTHSVHPRVSVGYDFGGWRIAADYARYRKWNNSKYSVSIKKLQNQYNKKTENQENGTFHAASSLGLSAVYDFKLNDKFKPYIGARVAYGHVRHSIDSTKKTTGFLTTAGARGAAPTVSSPYKNTQDAHQESNSIRRVGLGVIAGVGFDITPNLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (O44130)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Rho GTPase-activating protein syd-1
Sequence:
MPHTPPPNKKLSRATSLDSPPEKTIFRIDTVDLDLPSTNNGSTSMAADDQSQDEEHSAHSVLFPSMRLMLAAMLCCCFITLSISSSNLAVALICMTSCPVHGYGGTLEWQSQQEGLVLAAQNAGSLIMIVTGMWADRLNGKWMVFIGLLLCCIGNLMLPLLASKSFWFAVLARISIGASDACLMPAVNSLITRWFPQAERPAAIGLISGGRQIGTLFILPTAGYLCTRKDILDGWPAIFYLSATISVLVTVFWIPFGADKPAKQICISSREKEFIETRIACESIGKRTDRTRRVPYGAMLHSKPLWACIFALICHEYPLVIMLQFLPNYMRDVLEFAPTKNGIIAALPILCLFLSKTFSSSLSSYLTTKLRLDKTFVCKGFNAVASAGLAICISFVPFFNKESAFLAVFCLCGAMIFAGLHTPGVITAMVQIAPAFSGIITGWSFFAVAWFSIGNKILTKYIVQSGSVTEWGMVFRVSALVAALPVIVFTIWGSADREWWAAPSSKCSVASFHRPSIRDRSREMSRATSSTSLGQQSRVSSTR
Protein: WD repeat-containing protein 26 homolog (Q7K0L4)
Organism: Drosophila melanogaster (Fruit fly)
Function: G-beta-like protein involved in cell signal transduction (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H7D7}. Mitochondrion {ECO:0000250|UniProtKB:F1LTR1}.
Interaction partners:
- Ran-binding proteins 9/10 homolog
- GH10162p
- Houki
- Homeobox protein goosecoid
- LD41464p
- FI21269p1
- E3 ubiquitin-protein transferase MAEA
- Ubiquitin-conjugating enzyme E2 H
- RH01588p
- Protein yippee
Sequence:
MQSTSSTSSGSCSRPLEGSTLNSGGSAENVARDGGSGDDSVGIGDENPSGSSAATNGHDSKHNGFIVNNNGSSSRIVDGENNRENTSCSGVQLDKSNQEIIRLIGQYLHDVGLDKSVQTLMLESGCYLEHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKLATITEMKFILLEQKYLEHLDDGNPLDALHVLRSELTPLQHNITRVHQLSSYMMCSTNQDLYQRAKWEGKGILSRALVMERLQTFMPPSVMMSPRRLRTLLQQAVELQSQHCPCHDMAWETNLETVSLLTDHCCTTDGFPMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDPYKLTLKHRRVLDGQAQLSVSFVSWSPDSKLILVGGTEDSHELYIWNVDDGKLVVKFSQSLEDSLACGAFSRDGARFVCGGQKGQLYLCDLNGTIVDSWEGVRVNSIAFRADNKTILAADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIHSCFGGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSATTESDDCSSSSSSSSWNMT
Protein: U3 small nucleolar ribonucleoprotein protein imp3 (U3 snoRNP protein imp3) (O13835)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein imp4
- KRR1 small subunit processome component homolog
- Uncharacterized protein C3B8.09
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar RNA-associated protein 6
- U3 small nucleolar ribonucleoprotein protein mpp10
- Probable U3 small nucleolar RNA-associated protein 18
- Uncharacterized protein C18B11.06
- Nucleolar protein 58
- mRNA export factor elf1
Sequence:
MRILKHHEQKLLRKVDFLNYKNDDNNHRDVMVMRRYHISKREEYQKYNIICGKFRQLAHRLSLLDPTDPFRLQYENLLLEKLFDMGILPSKSKMSDIENKANVSAICRRRLPVIMCKLRMSQVVSEATRLIEQGHVRVGPHVITDPAYLVTRSLEDFVTWTDTSKIKRTIAKYNDKLDDYDLL
Protein: SSD domain-containing protein (Q09938)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ground-like domain-containing protein
- Ground-like domain-containing protein
- Ground-like domain-containing protein
Sequence:
MRCRIPTLDKKLEKVFAWYTKHLLVDYYYVFLIAPVILTAICSCGFYWIKELTLLDARKLYTPVSAPSWKEEQVFSELWPVKSYEFLPERTFQWNRYLYLVVHGRPYENGTYPNILEGSYLNDIAKIEEELVTNVSFPREAALEDNPALMRKRHLNETEIEENRNITITFKDVCMNWYGDCYREKNVIELLKRRHELNKRGISVTFPQVNQEGTPIYIAFVIGGVDTYPNDTIKYARAMRLWYFLKFDDEEQEQLAKFWEDTAEKFVRETYADHPTIQCHIKHSRIVDQGLTRNANRLKPYFNVTIAVLVLFTAFYSVKWYFRMDHSWPLHIDWLRSKPMLALGGVLSSVLAILSGIGLLLWFGMFFAEITLIAPFLVLSIGVDDMFIAVAAWHNTEMKYPGRSPKVMKKRMIEAMSESAVAIFITSFTDVLSFGAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALMVISAKAQMSGRNSCMPCITAGDIYTIEDGSLQPNLKKKKSKSRKDAKAEKEKKDEAKNDKNMEIEENAENAEKSSYDSSPDPSQIHIPVKSRGAMGHFFRDYYVPWLLNWKTKLFMFVTFIIYLGISVYGICVMEQGLDYDKLLLHSDPLVEALKREIELFHGGDQIEIAIQNCPNITIAESRDRIELVAQEFENISYSLGGKGTSFWMREYKKYSNLTGSYLNDNRESWIVGVYEWSQLFAFYKLWSQDFVWANESDYDTLELKSYRFRIGVHRLSTPTDLVLITEELRGVADRHPDLNIVTYQQSRAIADQLNVILSSTITNDTLAMFCMFCVALIFIPNPICALFITFAMVTIDIGVIGFLSLWSVKLDPISMITIIMSIGFSIEFSAHITHGFVSNDSNLSAFDRCVDAMEKLAWPVVHGSLSTILGVFVLAFIDSYMVLVFFKTISLVLIIGAWHALMLLPILLSMCIPVIERLSDASKKASDRRRKLKENKNSVYAINLPVNVSS
Protein: Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET) (P55145)
Organism: Homo sapiens (Human)
Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
Subcellular location: Secreted {ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914, ECO:0000269|PubMed:22637475, ECO:0000269|PubMed:29497057}. Endoplasmic reticulum lumen {ECO:0000305|PubMed:29497057}. Sarcoplasmic reticulum lumen {ECO:0000269|PubMed:22637475}. Note=Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057). {ECO:0000269|PubMed:22637475, ECO:0000269|PubMed:29497057}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Protein disulfide isomerase CRELD2
- DnaJ homolog subfamily B member 11
- Stromal cell-derived factor 2-like protein 1
- Endoplasmin
- Protein disulfide-isomerase A4
- Ubiquitin-conjugating enzyme E2 N
- X-box-binding protein 1
- Reticulon-1
- Hypoxia up-regulated protein 1
Sequence:
MRRMWATQGLAVALALSVLPGSRALRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
Protein: NBPF9 isoform 1 (A0A2K7P776)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
Protein: Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein (Q9FKZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein bL31c
- Large ribosomal subunit protein bL21m
- 50S ribosomal protein L33
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL9c
- Large ribosomal subunit protein bL28c
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- At5g09770
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS9c
Sequence:
MAKWWRGLRSVTAEVADLPASSFGRSIRCIHQYQTIQAIPREATGRGVSARDRTIGRIPAVVFPQSLLDTDASKRGVSRKQLLTADKKQIKSIIDSVGLPFFCSTTFQLQIRAGQGSSTLVESGRVLPLKVHRDEETGKILNLVFVWADDGEKLKVDVPVVFKGLDHCPGLQKGGNLRTIRSTLKLLGPAEHIPSKIEVDVSNLDIEDKVLLQDVVFHPSLKLLSKNETMPVCKIVATSPVKEPEAVQA
Protein: Kinesin-like protein KIFC1 (Kinesin-related protein 1) (Q5XI63)
Organism: Rattus norvegicus (Rat)
Function: Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9QWT9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9QWT9}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9QWT9}. Early endosome {ECO:0000250|UniProtKB:Q9QWT9}. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000250|UniProtKB:Q9QWT9}.
Interaction partners:
- Kinesin-like protein KIF11
- DLG associated protein 5
- Cell division cycle protein 20 homolog
- Kinesin-like protein KIF2C
- Kinesin-like protein
- Kinesin-like protein KIF18B
- Kinesin-like protein KIF15
- Kinesin-like protein
- Sperm-associated antigen 5.
- Mitotic spindle assembly checkpoint protein MAD2A
Sequence:
MRGRGSRDTGTQSAAFASRPVRTTVDMQAQRAPLMEVKRNLELSTTLVKSSSRLPLPGSRLKRGPDQMEDGLEPAKKRTRGMGTVTKVDTSRPRGPPLSAVSTAAQKGPRKTGPRGCSAVGPVLRNQKPAPAAPAQKPGTSTAPAVAGKKPGKRPAWDLKGQLCDLHEELKQYREKTQTLDRENQGLREQLREVQEQATTLGTERNTLEEELASVRRRAEQSQQKLETLGARVLELEECLGTKERLVQELQTERLQLQEERSTLSTQLEEREREFQASEAALSSSRAEVLCLRQKTAAQVTLLAEQGDRLYGLEMERRRLHNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFPPGPAGPSDPPTRLCLSRSDDRRSTLTRAPAAATRHDFSFDRVFPPGSKQEEVFEEISMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQEMSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGDCEIRRAGPGSEELTVTNARYVPVSCEKEVEALLHLAQQNRAVARTAQNERSSRSHSVFQLQISGEHAARGLQCGAPLNLVDLAGSERLDPGLTLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK
Protein: 6-phosphofructo-2-kinase 2 (6PF-2-K 2) (EC 2.7.1.105) (Phosphofructokinase 2 II) (Q12471)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Synthesis of fructose 2,6-bisphosphate.
Interaction partners:
- ATP-dependent 6-phosphofructokinase subunit alpha
- Fructose-1,6-bisphosphatase
- Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W
- ATP-dependent 6-phosphofructokinase subunit beta
- 6-phosphofructo-2-kinase 1
- Fructose-2,6-bisphosphatase
- Hexokinase-2
- Hexokinase-1
- Glucokinase-1
- N-acetylglucosamine kinase
Sequence:
MGGSSDSDSHDGYLTSEYNSSNSLFSLNTGNSYSSASLDRATLDCQDSVFFDNHKSSLLSTEVPRFISNDPLHLPITLNYKRDNADPTYTNGKVNKFMIVLIGLPATGKSTISSHLIQCLKNNPLTNSLRCKVFNAGKIRRQISCATISKPLLLSNTSSEDLFNPKNNDKKETYARITLQKLFHEINNDECDVGIFDATNSTIERRRFIFEEVCSFNTDELSSFNLVPIILQVSCFNRSFIKYNIHNKSFNEDYLDKPYELAIKDFAKRLKHYYSQFTPFSLDEFNQIHRYISQHEEIDTSLFFFNVINAGVVEPHSLNQSHYPSTCGKQIRDTIMVIENFINHYSQMFGFEYIEAVKLFFESFGNSSEETLTTLDSVVNDKFFDDLQSLIESNGFA
Protein: Pre-mRNA-splicing factor CWC22 homolog (Nucampholin) (Q9VJ87)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q9HCG8}.
Interaction partners:
- Eukaryotic initiation factor 4A-III
- Pre-mRNA-processing factor 17
- Cwc25
- Spliceosome-associated protein CWC27 homolog
- Protein BUD31 homolog
- Splicing factor YJU2
- Cell division cycle 5, isoform A
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-processing-splicing factor 8
- CG4973 protein
Sequence:
MGESDAESDSSSNSSSSDTSSGSDSDARSESSSSESSGREEEEAKQEESAKDAKKTDDTDRGEKRAKERDAGQDEQPTEQKKTPAAEPRSERQHISHSAGVEKQQEEAVAAAEAESEKLNEAKKVETPVQRKEEAEASSVTKELNSPKAQEENAARELEERRKDEEQPVTTNGSSKESPVEAAAETVKPPTADHIEEGEITDKDEDDLPTKEEKKAVASKSPPKETQRKQSRSPDGKRRRPRSSSRSPSPSSRRRRRSRSKGSRTRSRSKSPIRRRSNSLERRRVERQRRHEERDKRDEERAKEREKRHQKGEPTSSRRRDDSREKKRSPERKRDRSSSTPKSKSSKTPRHTETTETNADNETVTEPAAKITERQRKTVDVLTSRTGGAYIPPAKLRMMQSQITDKSSAAYQRIAWEALKKSIHGYINKVNVTNIAIITRELLRENIVRGRGLLSRSIIQAQAASPTFTHVYAALVSIINSKFPNIGELLLKRLVIQFRRAFRRNDKMVCMSATRFIGHLVNQRVAHEILALEILTLLVETPTDDSVEVAIAFLKECGMKLTEVSSKGIGAIFEMLRNILHEGKLDKRVQYMIEVLFQIRKDGFKDHQAVVPELELVEEDDQFTHLMMLDEATETEDILNVFKFDDNYAENEDKYKGLSREILGSDDGSSSGSGSGSDSDSDSDGESGSDAEKKAEAGDIIDSTETNLIALRRTIYLTINSSLDYEECAHKLMKMQLKPGQEIELCHMFLDCCAEQRTYEKFYGLLAQRFCNINKIYIPPFEEIFKDTYQTTHRLDTNRLRNVSKFFAHLLFTDAISWDVLECIQLNEDDTTSSSRIFIKILFQELAEYMGLGKLNAKLKDDVLVESIAGLFPKDNPRNTRFSINFFTSIGLGGLTDDLRRFLKNAPKSVPAINAEILANAGGNPFRDGSAPAGNTKVAPSSSSSSSSSSDTDSEDSSEEDSSSDSSSESSSSDSSSEPKKKRKRKDKDKKKSKKATKEKSKKTKNKKKKKKAEKEQEKEKEKQRKSKKEKEKDKKRKKEEKKAAKKKSKHRRKSQESSDSSGSEDSDKSTSESSDSSNSSSDESDAEPQAKIKRQEHVEKNKFRGRTQDSDEFNLEGPGSKNRFQPNGNGQRRRDNSTGRERNRENSSYDRERNRGNSSYDRERKRGNSSYDRERNRESSYDKERKNRNAVAHDRQRKRDRSRSYERPTIRENSAPREKRMESSRSEKDSRRGDRSSRNERSDRGERSDRGERSDRGERSDRGERSDRGERSDRGERSDREKERSRAKERERDRDRDLKGQRERKRERDDGSRDRSRRERSSRRSKGRS
Protein: Forkhead box protein F (FOXF homolog) (P91278)
Organism: Caenorhabditis elegans
Function: Transcription factor that is required for cell fate of coelomocytes which are non-muscle mesodermal cells. Acts in concert with, and by activating expression of, the homeodomain gene ceh-34. Binds to the sequence motif 5'-ATAAA[T/C]A-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:20335356}.
Interaction partners:
- Putative forkhead-related transcription factor fkh-5
- C2H2-type domain-containing protein
- Homeobox protein ceh-34
Sequence:
MECSTAIYSLANALGPLKLDSTAPNNSHRTIKAENYFNEDEEDYNENSHEDSEDSKEDSDGQGCRSRKRKEKPPFSYIALIAMAISKRPDKKATLAEIYSYLQENFEFFRGEYAGWRNSIRHNLSLNECFVKLPKDTGESYRGRKGHKWTISDSCEFMLEENGFRRRPRGYKARKRTHFPGVTASNEMGIGGATFDYPSSTTELTDSGTSSLNTDVKNILLNGGEDFGPSISDQLVSSTTSAVLPSLNGPDQSPIYPNYFGYGTAEFPMQWASPTYDWPYYATPHIGLCSSDFPGISPSPTVTPQVSPYFYPPAITTASSFMDDWRFGVSSAAVGAYDSSASFLAAETTAGDVAIPQDLSDC
Protein: Terpene synthase 6, chloroplastic (IrTPS6) (EC 4.2.3.-) (A0A1W6QDI6)
Organism: Isodon rubescens (Rabdosia rubescens)
Function: May be involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities.
Subcellular location: Plastid, chloroplast {ECO:0000250|UniProtKB:A0A0U4CDK4}.
Interaction partners:
Sequence:
LLNKDVLSSTLASILALHKWGLGQHHIAKGLHFLELNFASATDNSQITPLGFDIVFPAMLDHAADLSLNLRLDPTTLNDLMNRRDLELQRCTENGSAETEVYMAYIGEGMGKLHDWESVMKYQRKNGSLFNSPSTTAAAFIALRNSDCLNYLYSALNKFGSAVPAVYPLDIYSQLCIVDNLERLGISRFFSTEIQSVLDETYRCWLQGDEEIFMDASTCGLAFRTLRMNGYNVTSDPITKILQECFSSSFRGNMTDINTTLEIYRASELILYPEERDLDQHNLRLKTFLEQELSSNGFIQSCQLGRNINAEVNQAIEYPFYAIMDRMAKRKNIENYNIDNTRILKTSYRSPNFGNKDFLSLSVEDFNRCQVIHREELRELERWVIENRLDELKFARSKAAYCYFSAAATIFSPELSDARMSWAKNALMTTMVDDLFDVTGSVEEMKNLIQLVELWDVDVSTECCSHKVQILFSALKRTICEVGDRAYQLQGRSIRSHIIVIWLDTLHSMMKEVEWTRDKFVPTMDEYVSNAYVSFALGPIVLPALYLVGPKLSEEMVNHSEYHNLFKLMSTCGRLMNDIRGYEREHDDGKLNAMSLYIMNNGGEITPEVAILEIKSWNDRQRRDLLSLVLEEKSVIPKACKDLFWHMCSVVHLFYNKDDGFWSQELIEVVNQVIHQPILLN
Protein: Glutathione S-transferase alpha-4 (EC 2.5.1.18) (GST 8-8) (GST A4-4) (GST K) (Glutathione S-transferase Yk) (GST Yk) (P14942)
Organism: Rattus norvegicus (Rat)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular location: Cytoplasm.
Interaction partners:
- Glutathione S-transferase Mu 1
- Glutathione S-transferase Mu 7
- Glutathione S-transferase theta-1
- Glutathione S-transferase omega-1
- Glutathione S-transferase
- Glutathione S-transferase kappa 1
- Glutathione peroxidase 1
- glutathione transferase
- Glutathione S-transferase Mu 4
- Microsomal glutathione S-transferase 1
Sequence:
MEVKPKLYYFQGRGRMESIRWLLATAGVEFEEEFLETREQYEKLQKDGCLLFGQVPLVEIDGMLLTQTRAILSYLAAKYNLYGKDLKERVRIDMYADGTQDLMMMIIGAPFKAPQEKEESLALAVKRAKNRYFPVFEKILKDHGEAFLVGNQLSWADIQLLEAILMVEEVSAPVLSDFPLLQAFKTRISNIPTIKKFLQPGSQRKPPPDGHYVDVVRTVLKF
Protein: Pseudin-4 (P83191)
Organism: Pseudis paradoxa (Paradoxical frog)
Function: Possesses antifungal activity against C.albicans and is also active against E.coli and S.aureus.
Subcellular location: Secreted {ECO:0000269|PubMed:11689009}.
Interaction partners:
Sequence:
GINTLKKVIQGLHEVIKLVSNHA
Protein: Uncharacterized protein (Q381C4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLTRKLRNMLEKPPTKGRSGGTVKSQVFIVGKRMVPTGCESLVCLSSRKPEMRQQRRVVFHGLAPGDVIRAPARFFNMIVEERRLPKPQHCWLIRANCMKRGPLWTRPSPPPCAHHMSVSSCTRCPWMSVVPAVAPDIKAGNLRHALESLPHVSPIGGEGFAGSEEFGGVRVDSTGCRPLPRLSLNFLEPFSPPIKLHLMREVEFHFHHTHDPKDVNRGTASKSVPVGGRFRFLDSQPDATGCLLCTLEQDRLLKLLNLWADCLPLHVQKCLCSVFVLQHPHEAAEHSWDCDLHVALLLQKDTVMCGEQSPLCGPSQPDTTLSREEQQFVDAVLSAAPLTTNIGVSTVCTDGSVAHLYPHARRVDVFASTELAALSLPFVAAAAAVNSCFPCKALHGPTERAVTASLPFMHSVLAFALEGRDLGSLQSTRCPSAWRHAASLEAVGSVVLSLISERRISGDGNVMLLGGGSVARGGRRGSGSQLLLAGLVQWLGALFPQCAVHVLGENRGEGGLPVVCIFVIDNEADVDLLMGSLRDGKGFGLRESVTQLSQLVLLQLSFDGEFRFLVDGLSAIQRCLAGKKALHVDAGIIDVDPWAATVVGYAAVEI
Protein: Cathelicidin-derived antimicrobial peptide 1 isoform B (H8PHH9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKVQVRSLILLAVAVLQVRSQNQTETRYEDIILVALPQLLPGEEQAFRPILNQLQVETLNTEDVDQSEVSVRLTFPIQETFCSKSQGQPGKPCPLKKNGKLMMCSMKVRHPILEASNNLNTDLSTFVCEYMDAEDALQQKIRTRRSKVRICSRGKNCVSRPGGGSVIGRPGGGSPPGGGSFNDEFIRDHSDGNRFA
Protein: Chromosome 10 open reading frame 90 (Q5T025)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPKEERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKVMASSPAGVMCVVHRCRIST
Protein: Rho-related GTP-binding protein RhoB (P62747)
Organism: Rattus norvegicus (Rat)
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity).
Subcellular location: Late endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Nucleus {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity). {ECO:0000250}.
Interaction partners:
- Rho-associated protein kinase 1
- Rho-related GTP-binding protein RhoH
- Rho-associated protein kinase 2
- Protein diaphanous homolog 3
- Intersectin-1
- Serine/threonine-protein kinase N1
- Rho guanine nucleotide exchange factor 12
- Protein diaphanous homolog 1
- Rho guanine nucleotide exchange factor 2
- Rho guanine nucleotide exchange factor 11
Sequence:
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
Protein: Putative carboxymethylenebutenolidase (EC 3.1.1.45) (Dienelactone hydrolase) (DLH) (Q07505)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Delta
Sequence:
MLITETFHDVQTSYGTTLRIYVYSPKIAGYPQAKFPGVILYSEIYQVTGPVRRFGQRIASEGYVVVAPAIYHNFMGPEALPYDVQGTDIGNEYKIKKPLESYDEDNKLCCDLLFQLPQFDGKRIGSTGMCLGGHLAFRALLDKRVTCATCFFPTDIHSRTLGLGQNDNSLERVSKELGNNQEMVLIFGTADTHVDPQGRDLIRKTLRDHGVKFTFLEILAAQHAFIRDEFSKGRFDSAITQSCLGFLFEQFNRKLRIDLGEFVDDNTPLEHVC
Protein: S58 family peptidase (Q9I3M6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable amino acid permease
Sequence:
MRARQLGITLGLGTPGPFNAITDVPGVRVGHSTLNQRIDGRQVRTGVTLVQPRAGAARLQPCFAGCHVLNGNGDATGLEWIREAGLLTTPIAITNTHSVGAVRDALIAEERAELGDSGLYWCMPVVMETFDGLLNDIWGQHVGARQVGEALACAESGPVREGSVGGGTGMICHEFKGGIGSASRRLPAEQGGWTVGALVQANHGQRRELRVDGYPVGRRLGDIPSPFSEEGTPGMGSIVVILATDAPLLPHQCQRLAQRASIGIARTGGGTEDSSGDVFLAFATGNQDLPPADYARKDLPQSTPLRMLNNDHISPLFAAAAEAVEEAIVNVLLAGEDMRTEDGRLVPALKGERLLAALRETGWPGR