wanglab/gogpt-training-data huggingface dataset:
Protein: Serpin family A member 5 (F7EMJ6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Prothrombin
- Vitamin K-dependent protein C
- Urokinase-type plasminogen activator
- Plasminogen activator inhibitor 1
- Serine
- Aa1018
- Tissue-type plasminogen activator
- Antithrombin-III
- Cathepsin B
- Caspase-1
Sequence:
MAATMRFFPILCLVLFFSHGVASRQRSHSKEKKKSKESSVGAVGTSRSRDFAFRLYRALASEAPGQNVFFSPMSVSMSLGMLSLGSGLKTKAQILEGLGLSLQQGQEDMLHKGFQQLLQQFSQPSDGLQLSLGSALFTDPAVHIRDHFLSAMKTLYMSDMFSTNFGNPESAKKQINDYVAKKTNGKIVDLIKDLDSTHVMVVVNYIFFKAKWQTAFSSTNTHKMDYHVTPKKTIQVPMMNREDIYSYILDQNISCTVVGIPYQGNTFALFILPSEGKMKRVEDGLDERTLRNWLKMFTKRQLDLYLPKFSIEGTYKLEKILPKLGIQDIFTTHADLSGLTDHTNIKLSEMVHKSMVEVDESGTTAAASTGILFTLRSARPSSLKVEFTRPFLVVIMDGTNLYFIGKVIQP
Protein: Uncharacterized protein, isoform A (Q9VB53)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNCKLRRLDLLRNGQKSDCELHVSQPDKLKEGKRCPCIFRCHQVMLISASAEFERLIRDPEFQKNKRVISVDDASPTAYEALLLYIYTYEVCNAVTIDMCGDLMLLAERYEMLDFIDCYIDKLAHQEWPMEVVLQVFHLASEHHHPALMDLVAKKILPVATQVLMDNSFLKLSVKELKALMIILKKDGDLSDHELLTSLKNYQDVNNLRYEDMEQFQQLVEVTQLFGHVLFEVDGTIVVPEEEKPSPEE
Protein: X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP/AP lyase Ku70) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (DNA repair protein XRCC6) (Ku autoantigen protein p70 homolog) (Ku70) (O93257)
Organism: Gallus gallus (Chicken)
Function: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P12956}. Chromosome {ECO:0000250|UniProtKB:P12956}.
Interaction partners:
- DNA ligase 4
- DNA-dependent protein kinase catalytic subunit
- Uncharacterized protein.
- X-ray repair cross-complementing protein 5
- Non-specific serine/threonine protein kinase.
- Double-strand break repair protein MRE11
- DNA repair protein RAD52 homolog
- Uncharacterized protein.
- Protein artemis
- Aprataxin and PNK-like factor
Sequence:
MEMWVLGEVGMAVLSAAAMADWVSYYRGDGPDEEEDGEQQEEEGPEAVADYRFSGRDSLIFLVDASKAMFEPYENEEAATPFDMTMQCIRNVYTSKIISSDKDLLSVVFYGMENNKNSADFKHIYVLQELDNPGAKRILELDQYRGDEGRVLFRETFGHNADYSLGEALWACSNLFSDVRVRLSHKRIMLFTNEDNPHANDSAKAKLARTRAGDLRDTGIILDLMHLKKPGGFDISLFYRDIINVAEDEDLGIQPDESGKLEHLMKKVRAKETRKRALSRLNLYLNKDLSFSVGVYNLIQKAYKPYPVKLYRETNEPVKTKTRVFNGKTGSLLLPSDTKRAQTYGNRQIAMEKEETEEVKRFDSPGLFLIGFKPLSMLKQHHHIRPSQFMYPEESLVTGSTTLFNALLMKCLEKEVMALCRYIARRNTPPRIVALIPQEEEVDEQKVQIAPPGFHIIFLPYADDKRNVDFTEKVPANREQVDKMKGIIQKLRFKYRTDSFENPVLQQHFRNLEALALDMLEPEQAEDLTMPKTEEMSRRLGNLVEEFKQLVYPPDYSPEGKAAKRKQAGDAQAEKRPKIEISEDSLRSYVQNGTLGKLTVSALKDTCRHYGLRSGGKKQELIDALTEYFSGR
Protein: Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (Q9Z2W9)
Organism: Mus musculus (Mouse)
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P19492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19492}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P19492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19492}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P19492}.
Interaction partners:
- Glutamate receptor 2
- Voltage-dependent calcium channel gamma-2 subunit
- Glutamate receptor 1
- Glutamate receptor 4
- Glutamate receptor-interacting protein 1
- PRKCA-binding protein
- Disks large homolog 4
- Protein shisa-9
- Voltage-dependent calcium channel gamma-3 subunit
- Disks large homolog 3
Sequence:
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
Protein: Alpha-amylase A type-1/2 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (Taka-amylase A) (TAA) (P0C1B3)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- 1,4-alpha-glucan-branching enzyme
- Glucoamylase
- Probable alpha/beta-glucosidase agdC
- Glycogen debranching enzyme
- Alpha-glucosidase
- glucan 1,4-alpha-glucosidase
- Alpha-glucosidase
- Alpha-1,4 glucan phosphorylase
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- Glycosyl hydrolase family 13 catalytic domain-containing protein
Sequence:
MMVAWWSLFLYGLQVAAPALAATPADWRSQSIYFLLTDRFARTDGSTTATCNTADQKYCGGTWQGIIDKLDYIQGMGFTAIWITPVTAQLPQTTAYGDAYHGYWQQDIYSLNENYGTADDLKALSSALHERGMYLMVDVVANHMGYDGAGSSVDYSVFKPFSSQDYFHPFCFIQNYEDQTQVEDCWLGDNTVSLPDLDTTKDVVKNEWYDWVGSLVSNYSIDGLRIDTVKHVQKDFWPGYNKAAGVYCIGEVLDGDPAYTCPYQNVMDGVLNYPIYYPLLNAFKSTSGSMDDLYNMINTVKSDCPDSTLLGTFVENHDNPRFASYTNDIALAKNVAAFIILNDGIPIIYAGQEQHYAGGNDPANREATWLSGYPTDSELYKLIASANAIRNYAISKDTGFVTYKNWPIYKDDTTIAMRKGTDGSQIVTILSNKGASGDSYTLSLSGAGYTAGQQLTEVIGCTTVTVGSDGNVPVPMAGGLPRVLYPTEKLAGSKICSSS
Protein: Solute carrier family 49 member A3 (Major facilitator superfamily domain-containing protein 7) (Myosin light polypeptide 5 regulatory protein) (MYL5) (Q6UXD7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAGPTEAETGLAEPRALCAQRGHRTYARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSCILAVFFHTPYRRLQAESGEPPSTRNAVGGADSGPGVDRGGAGRAGVLGPSTATPECTARGASLEDPRGPGSPHPACHRATPRAQGPAATDAPSRPGRLAGRVQASRFIDPAGSHSSFSSPWVIT
Protein: Heavy metal-associated isoprenylated plant protein 21 (AtHIP21) (AtHIPP21) (Q9LF57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heavy-metal-binding protein. Binds cadmium. May be involved in cadmium transport and play a role in cadmium detoxification.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9SZN7}.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 12
- Heavy metal-associated isoprenylated plant protein 39
- Heavy metal-associated isoprenylated plant protein 9
- Heavy metal-associated isoprenylated plant protein 3
- At2g28660
- Protein CutA, chloroplastic
- Heavy metal-associated isoprenylated plant protein 16
- Heavy metal-associated isoprenylated plant protein 1
- Heavy metal-associated isoprenylated plant protein 10
- Metallothionein-like protein 1A
Sequence:
MGAFDYISSFCSYTYANAKTKRKPLQTVDIKVKMDCDGCERRVRNVVRRMKGVKSVEVNRKQSRITVNGHVDPNKVLKRVKSTGKKAEFWPYIPQHMVYYPFAPGMYDKRAPAGHIRNPTQSFPTANAPEENYVSLFSDDNVHAACSIM
Protein: Indole-3-pyruvate monooxygenase YUCCA2 (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA2) (Q9SVQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin biosynthesis. Converts the indole-3-pyruvic acid (IPA) produced by the TAA family to indole-3-acetic acid (IAA). Unable to use tryptamine (TAM) as substrate. Required for the formation of floral organs and vascular tissues. Belongs to the set of redundant YUCCA genes probably responsible for auxin biosynthesis in shoots.
Interaction partners:
- L-tryptophan--pyruvate aminotransferase 1
- Tryptophan aminotransferase-related protein 2
- Tryptophan aminotransferase-related protein 1
- Aromatic aminotransferase ISS1
- Amidase 1
- Indole-3-acetaldehyde oxidase
- Auxin efflux carrier component 3
- Auxin transporter protein 1
- Nitrilase 3
- Protein TRANSPORT INHIBITOR RESPONSE 1
Sequence:
MEFVTETLGKRIHDPYVEETRCLMIPGPIIVGSGPSGLATAACLKSRDIPSLILERSTCIASLWQHKTYDRLRLHLPKDFCELPLMPFPSSYPTYPTKQQFVQYLESYAEHFDLKPVFNQTVEEAKFDRRCGLWRVRTTGGKKDETMEYVSRWLVVATGENAEEVMPEIDGIPDFGGPILHTSSYKSGEIFSEKKILVVGCGNSGMEVCLDLCNFNALPSLVVRDSVHVLPQEMLGISTFGISTSLLKWFPVHVVDRFLLRMSRLVLGDTDRLGLVRPKLGPLERKIKCGKTPVLDVGTLAKIRSGHIKVYPELKRVMHYSAEFVDGRVDNFDAIILATGYKSNVPMWLKGVNMFSEKDGFPHKPFPNGWKGESGLYAVGFTKLGLLGAAIDAKKIAEDIEVQRHFLPLARPQHC
Protein: Protein ERD1 homolog 2 (Q10151)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDLEVVEFPLHHKLALPFRIGLLVIVGTWLWSVCYHLIYILNRYQPISPNPRGSLNSKWYHLLQIPLSNRHTDLEENTEFKANLVSPVDFHAGYCFAAILSISWATGFILFLKKTQGDIGGLYSHPIYPLLWVITAFILIVFPFPWRYRSSQRGLRKSIIRVFLFFQADFRSPYKDFIVSEIFTSYAKALGDFYIFGCVLQGHISKFTLRPDLKCDGTFFVPLAMAYPFIVAILQCLHYGLSRRKHTFKINLLSALKHATALPVIYLSAIIHAKQTKFTLTSGHGYLFWLWILSALLSSAYTFLWDVFIDWRIRFPFHKSINHKRFPMFIYAIGCFINFILRVTWSMKLHPRLHQFHEYEMGIFSFEMLEILRRFLWLFFHLDAISS
Protein: Mce-family protein Mce1F (L0T2W6)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Mce-family protein Mce1B
- Conserved integral membrane protein YrbE1A
- Mce-family protein Mce1A
- Possible Mce-family lipoprotein LprK
- Conserved integral membrane protein YrbE1B
- Mce-family protein Mce1C
- Mce-family protein Mce1D
- Probable conserved Mce associated transmembrane protein
- Probable conserved Mce associated membrane protein
- Conserved hypothetical integral membrane protein YrbE2A
Sequence:
MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVHSVSAVGEQYIDLVSTGAPGKYFSSGQTITKGTVPSEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSPADTSPRPLPSGTYCKIPQDAQLQVRGARNIPCVDVLGKRAATPKECRSKDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
Protein: Hillarin (D-Hillarin) (D-hil) (Q0E908)
Organism: Drosophila melanogaster (Fruit fly)
Function: May act as a modulator of septin function during cytokinesis in the developing nervous system.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:15818553}. Cleavage furrow {ECO:0000269|PubMed:15818553}. Note=During mitosis, detected at the cell cortex in metaphase but is concentrated at the cleavage furrow at telophase. Colocalizes with pnut at the cell cortex. {ECO:0000269|PubMed:15818553}.
Interaction partners:
- AT02057p
- Uncharacterized protein, isoform C
- chitin synthase
Sequence:
MYRPNFYESTCLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHVPKSGPGHLDQTSVGIRQALNAPRTNKFVNEQIRGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDYKYGRFDASALHIAHALKQTEIQKAYNKAREKPIDFYLAREEQAHLEMKHRKEEDDLYRKFASKRAEEDRKIQDEFQDEWERELQRLTHKFEKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETAALVDRQSSEMLELISARRSEYMQSESIFLDDEFSEGAVPVEYPLNAPIPAPPAVSKFQIYTDPIEFEDVDRIAISVAQEDQKTFTDLVRQLVGRCTTDIEKARTIFRWITVKNLNAMHFDDDLRGDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPGVKFQDSRFRNSWNAVYVAGAWRFVQCNWGARHLVNAKEAPKQGRGKNDSLRYEYDDHYFLTDPREFIYEFYPLQEEWQLLKRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATVRIAMPTDMQSCLIFHYNLKFYDSDEELSYDGVSLKRFVMQSVIGNIVAFRVHAPCSGAFLLDIFANAVTPQEYLTGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKATRLFGLIPITHQDPLIFAGRSLDLQFRMSRPLTDFMATLHKNGIEEKKLAKYVTHSTLDDIVTFIINFPEEGQYGLDIYTRELGGPQHHHHHNNNNSSSSSGEKHLLTHCCKYLINSSKRN
Protein: Bidirectional sugar transporter SWEET11 (OsSWEET11) (Disease resistant allele Xa13) (Q19VE6)
Organism: Oryza sativa subsp. indica (Rice)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Required for pollen viability. Confers sensitivity to bacterial blight mediated by X.oryzae pv. oryzae (Xoo) in its Xa13 allelic form (e.g. cv. IR24), probably by providing the sugar required for the pathogen growth. However, a recessive resistance can be associated with the xa13 allele (in which the promoter is mutated leading to reduced induction upon pathogen infection, e.g. cv. IRBB13), specifically toward Xoo Philippine race 6 and Indian race PXO8.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
Interaction partners:
Sequence:
MAGGFLSMANPAVTLSGVAGNIISFLVFLAPVATFLQVYKKKSTGGYSSVPYVVALFSSVLWIFYALVKTNSRPLLTINAFGCGVEAAYIVLYLVYAPRRARLRTLAFFLLLDVAAFALIVVTTLYLVPKPHQVKFLGSVCLAFSMAVFVAPLSIIFKVIKTKSVEFMPIGLSVCLTLSAVAWFCYGLFTKDPYVMYPNVGGFFFSCVQMGLYFWYRKPRNTAVLPTTSDSMSPISAAAAATQRVIELPAGTHAFTILSVSPIPILGVHKVEVVAAEQAADGVAAAAAADKELLQNKPEVIEITAAV
Protein: Xylose isomerase (EC 5.3.1.5) (P24300)
Organism: Streptomyces rubiginosus
Function: Involved in D-xylose catabolism.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MNYQPTPEDRFTFGLWTVGWQGRDPFGDATRRALDPVESVRRLAELGAHGVTFHDDDLIPFGSSDSEREEHVKRFRQALDDTGMKVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTIRNIDLAVELGAETYVAWGGREGAESGGAKDVRDALDRMKEAFDLLGEYVTSQGYDIRFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQNGIKYDQDLRFGAGDLRAAFWLVDLLESAGYSGPRHFDFKPPRTEDFDGVWASAAGCMRNYLILKERAAAFRADPEVQEALRASRLDELARPTAADGLQALLDDRSAFEEFDVDAAAARGMAFERLDQLAMDHLLGARG
Protein: Probable ribonucleases P protein subunit pop8 (EC 3.1.26.5) (Q7Z996)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ribonuclease MRP protein subunit rmp1
- Ribonuclease P protein subunit rpr2
- Ribonucleases P/MRP protein subunit POP7
- Ribonuclease P/MRP protein subunit POP5
- Uncharacterized protein C6C3.09
- Probable ribonuclease P protein subunit 1
- Probable ribonuclease P protein subunit 3
- Ribonucleases P/MRP protein subunit pop3
- Ribonucleases P/MRP protein subunit pop1
- Uncharacterized protein C16C4.19
Sequence:
MVLHQRLKSEWSYIILEVVGGTTPIDEIDDISLRHLITLALNQSFGIFGSAIPIDFLHRQSKFLYLRCHKEDKKKVLVALGSYVREPEQIRLMVLHASDFPCQAVPFS
Protein: Ferric uptake regulation protein (Q8EFN3)
Organism: Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU364037}.
Interaction partners:
- Flavodoxin
- DNA-directed RNA polymerase subunit alpha
- Ribbon-helix-helix protein repressor CopG family YbfE
- Superoxide-responsive transcriptional repressor of superoxide stress response AzrR
Sequence:
MTDGNQALKKAGLKITLPRVKILELMQGPENQHISAEDLYKKLLDLGEEIGLATVYRVLNQFDDAGIVSRHHFESGKAVFELSTQHHHDHLVCLSCGKVIEFSDEVIERRQDEIASKYNIKLTNHSLYLYGHCTNDNCEHNDE
Protein: Ecotin-like protein 4 (Q57ZP2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine peptidase, putative serine peptidase, Clan SC, Family S9D
Sequence:
MFGSRKASRRRSYRSRSTMGSRVDIDFCKFEEPPSPREGERRCLFVLDPLEHYVESKDRMVELLPGRVETVDGVNTYYINGCTTEEKFPGLDYTCYRVDLRDTYRSRCAVPPEATPEEKFISHRHRKLIPYNSRKPVVVYLPEDAQLHYRIWTGGQEVVAKKAEE
Protein: RH73259p (Vajk1, isoform A) (Q9V3G8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD27203p
- Cuticular protein 64Aa
- RE11315p
- Uncharacterized protein, isoform E
Sequence:
MKSMRTATSLALVLLLATSYVRAEDEKAAAPAEEKKAEPEAKAAEAAASEDTTKSKRGLHHYEDYHHHHVPHFPVHEEKTLTVIKKVPVPVPIEKIVHVPVEKHIHVPVKVKVPKPYPVIKHIPYEVKEIVKVPYEVPAPYPVEKQVHVPVHVHYDRPVPVKVHVPAPYPVEKKVHVPVKVHVPAPYPVEKIVHYNVEKHVHVDKPYPVEKVVHYPVKVPVDKPVPHYIDKPVPHYVDKPVPVPVIKKVPVPVHVPYDRPVPVHVEKPVPYEVKVHVPAPYPVIKEVPVKVEKHVPYPVKIPVEKPVHVHIEKHVPEYHEKHVTYKEPEFHHKHIEEDHHHAPIHHHSHPIVEHEHEVEHEFASHDYHSYYGY
Protein: Golgin subfamily A member 7B (Q9D428)
Organism: Mus musculus (Mouse)
Function: Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5. May be involved in protein transport from Golgi to cell surface.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q2TAP0}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q2TAP0}; Lipid-anchor {ECO:0000250|UniProtKB:Q2TAP0}.
Interaction partners:
- Palmitoyltransferase ZDHHC5
- Palmitoyltransferase ZDHHC9
Sequence:
MATEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNGFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSGSSSGSGSSSAGGGGAGAR
Protein: Probable U2 small nuclear ribonucleoprotein A' (U2 snRNP A') (Masculinization of germline protein 2) (Spliceosome-associated protein mog-2) (Q9BLB6)
Organism: Caenorhabditis elegans
Function: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:21504747}. Note=Expressed in the transition zone and pachytene region of mitotic nuclei.
Interaction partners:
- Splicing factor 3B subunit 1 domain-containing protein
- Splicing factor 3B subunit 3
- Splicing factor 3B subunit 4
- Probable small nuclear ribonucleoprotein Sm D2
- Matrin-type domain-containing protein
- Pre-RNA processing 21
- PSP proline-rich domain-containing protein
- Splicing factor 3A subunit 2
- Probable small nuclear ribonucleoprotein G
- Probable small nuclear ribonucleoprotein-associated protein B
Sequence:
MVRLTTELFAERPQFVNSVNMREINLRGQKIPVIENMGVTRDQFDVIDLTDNDIRKLDNFPTFSRLNTLYLHNNRINYIAPDIATKLPNLKTLALTNNNICELGDIEPLAECKKLEYVTFIGNPITHKDNYRMYMIYKLPTVRVIDFNRVRLTEREAAKKMFKGKSGKKARDAIQKSVHTEDPSEIEPNENSSGGGARLTDEDREKIKEAIKNAKSLSEVNYLQSILASGKVPEKGWNRQMDQNGADGEAMES
Protein: Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] (P31394)
Organism: Rattus norvegicus (Rat)
Function: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P04070}. Golgi apparatus {ECO:0000250|UniProtKB:P04070}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P04070}.
Interaction partners:
- Thrombomodulin
- Endothelial protein C receptor
- Prothrombin
- Serpin family F member 2
- Coagulation factor VIII
- Plasminogen activator inhibitor 1
- Proteinase-activated receptor 1
- Serpin family A member 5
- Alpha-1-antiproteinase
- Antithrombin-III
Sequence:
MWQFRIFLLFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCRCAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL
Protein: Cyclin-C (Q62447)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 13
- Mediator of RNA polymerase II transcription subunit 12
- Cyclin-dependent kinase 19
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 12-like protein
- Mediator of RNA polymerase II transcription subunit 13-like
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAATTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS