wanglab/gogpt-training-data huggingface dataset:
Protein: Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1) (Q9H2V7)
Organism: Homo sapiens (Human)
Function: Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol. Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids. Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin. Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively. Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine. Essential player in lysosomal homeostasis. May be involved in necrotic or autophagic cell death.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:12408844}; Multi-pass membrane protein {ECO:0000269|PubMed:12408844}. Mitochondrion inner membrane {ECO:0000269|PubMed:12815463}; Multi-pass membrane protein {ECO:0000269|PubMed:12815463}. Note=Ocassionally localizes to mitochondria. {ECO:0000269|PubMed:12815463}.
Interaction partners:
- Sphingosine-1-phosphate transporter MFSD2B
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
Sequence:
MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI
Protein: Cortexin-3 (Kidney and brain-expressed protein) (Q4LDR2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein KIBRA
Sequence:
MDGGQPIPSSLVPLGNESADSSMSLEQKMTFVFVILLFIFLGILIVRCFRILLDPYRSMPTSTWADGLEGLEKGQFDHALA
Protein: 4-aminobutyrate aminotransferase PuuE (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (P50457)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). PuuE is important for utilization of putrescine as the sole nitrogen or carbon source.
Interaction partners:
- Gamma-glutamylputrescine oxidoreductase
- Succinate semialdehyde dehydrogenase [NAD
- Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD
- Succinate-semialdehyde dehydrogenase [NADP
- NADP/NAD-dependent aldehyde dehydrogenase PuuC
- Glutamate decarboxylase beta
- Glutamate decarboxylase alpha
- 4-aminobutyrate aminotransferase GabT
- Gamma-aminobutyraldehyde dehydrogenase
- Aspartate 1-decarboxylase
Sequence:
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEVQSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLCERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAVEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALSD
Protein: Glycolytic genes transcriptional activator GCR1 (P07261)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional activator required for the expression of glycolytic and ribosomal genes. Forms a transcriptional activation complex with RAP1, RAP1 providing the specific DNA-binding function and GCR1 providing the activation function. Can also bind itself to DNA to a core 5'-CTTCC-3' sequence (CT box). CT box-binding is not essential, but enhances the activation function of the RAP1-GCR1 complex in promoters that contain both DNA signals (only glycolytic genes). CT box-dependent transcriptional activation requires GCR2.
Subcellular location: Nucleus.
Interaction partners:
- Glycolytic genes transcriptional activator GCR2
- DNA-binding protein RAP1
- Triosephosphate isomerase
- Transcription factor TYE7
Sequence:
MVCTSTSSNFYSIAQYILQSYFKVNVDSLNSLKLVDLIVDQTYPDSLTLRKLNEGATGQPYDYFNTVSRDADISKCPIFALTIFFVIRWSHPNPPISIENFTTVPLLDSNFISLNSNPLLYIQNQNPNSNSSVKVSRSQTFEPSKELIDLVFPWLSYLKQDMLLIDRTNYKLYSLCELFEFMGRVAIQDLRYLSQHPLLLPNIVTFISKFIPELFQNEEFKGIGSIKNSNNNALNNVTGIETQFLNPSTEEVSQKVDSYFMELSKKLTTENIRLSQEITQLKADMNSVGNVCNQILLLQRQLLSGNQAIGSKSENIVSSTGGGILILDKNSINSNVLSNLVQSIDPNHSKPNGQAQTHQRGPKGQSHAQVQSTNSPALAPINMFPSLSNSIQPMLGTLAPQPQDIVQKRKLPLPGSIASAATGSPFSPSPVGESPYSKRFKLDDKPTPSQTALDSLLTKSISSPRLPLSTLANTAVTESFRSPQQFQHSPDFVVGGSSSSTTENNSKKVNEDSPSSSSKLAERPRLPNNDSTTSMPESPTEVAGDDVDREKPPESSKSEPNDNSPESKDPEKNGKNSNPLGTDADKPVPISNIHNSTEAANSSGTVTKTAPSFPQSSSKFEIINKKDTKAGPNEAIKYKLSRENKTIWDLYAEWYIGLNGKSSIKKLIENYGWRRWKVSEDSHFFPTRRIIMDYIETECDRGIKLGRFTNPQQPREDIRKILVGDLEKFRINNGLTLNSLSLYFRNLTKNNKEICIFENFKNWNVRSMTEEEKLKYCKRRHNTPS
Protein: Septin-14 (Q6ZU15)
Organism: Homo sapiens (Human)
Function: Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17922164}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17922164, ECO:0000269|PubMed:31450874}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DA97}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DA97}. Perikaryon {ECO:0000250|UniProtKB:Q9DA97}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9DA97}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32249155}. Note=Colocalizes with actin stress fibers (PubMed:17922164). Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9DA97, ECO:0000269|PubMed:17922164}.
Interaction partners:
- Septin-7
- Neuronal-specific septin-3
- Septin-10
- Septin-9
- Septin-6
- Septin-2
- Uncharacterized protein C17orf47
- Septin-5
- Septin-8
- Septin-11
Sequence:
MAERTMAMPTQIPADGDTQKENNIRCLTTIGHFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKSTLIDTLFNTNLKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYIDAQFEAYLQEELKIKRSLFEYHDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQTFKNKIMSELISNGIQIYQLPTDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVRGRHYPWGVLQVENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEAKRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTDTKKDKHRKK
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (Q8ILM0)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA-splicing factor CEF1, putative
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor CWC22, putative
- Pre-mRNA-splicing factor CWC24, putative
- Pre-mRNA-splicing factor BUD31, putative
- RNA helicase
- Pre-mRNA-processing protein 45, putative
- FHA domain-containing protein, putative
- Pre-mRNA-processing-splicing factor 8, putative
- RNA-binding protein, putative
Sequence:
MSEVYSIEPKTHGKVIIYTSLGELEIHLFSNECPEACRNFIQHCLNNYYNKNEFFRVIPRFLIQTGDHTNTGLHNEYAFSSPFKNEYNSRLKFLYTGCLSFANLNIDKPSNGSQFFITLDKAEYLNNKNTLFGKVAKHSIYNLLKFNNIKTNKHDKPIEDIPYIEYVKIIENPFHHLVPSINYEYNTKNQNVKDKNEYLNKTKKKKEQNLLSFDYDQEISDDSETFFRGDKDQTVKQKNVSSYDKFGNVEDNKGEDDKGEDDKGEDNKGEDNKGEDNKGEDDKGEDIKGEDIKGEDIKRDEKNNKTTEDKINTLKKRTCDIENSNRKKNKTSSSIKDIINMDEEYLKNMKKYNKMSKKEREKLSLKKLQDFDNRLKDLFSRENNEESTKHNWLNKSGLKFHIDSSNAYEYEDVKKNMVDTMEREKKNSYHSKYKTEKYLKQKNEFK
Protein: GH11066p (Q9VBS3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- CHK kinase-like domain-containing protein
Sequence:
MPPQTNDENVCEREVPIPGWVKPEVFEDLLKDNVKDYKKTKALRAKAGVAAGENYATIMLRLELDVETKDKSEVTKAFMLKTPHDTDAYRKLLQETNIFDVERGMYLVVVPELEQMYRDVGLEVKFGAEAYEIKVSENYVLLEDLRPRGFKNVDRLQGLDQAHTESVLRKFAQWHAASAVRVDLKGPYEEKYTNGFFKSKEIMNFFCDRSAKILLNNIDQYDGHAAYIKDLQSVSEKLFDIYNDIKEPKSDEFNALNHGDGWSNNIMFQYNDKNEISNTYFVDLQLPKWGSVAQDLYYFLLSSTSLDIKTEKFDYFVWFYHSELVKHLKLLNYSKKLPTLRSIRNALNKYSGWAFICSISVMGVVLLDPTDDADFDKIISNEHSNFTNSIYTNPRYRRHMKVVLPWLQHRGALE
Protein: Glutamate decarboxylase 1 isoform 2 (A0A0S2Z4D9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNQSPDDGVRYDHGWLPAPRGQGQLLPDGHLQPSRYPV
Protein: Peptidoglycan glycosyltransferase RodA (EC 2.4.99.28) (Non-canonical transglycosylase RodA) (P9WN99)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Transglycosylase involved in peptidoglycan cell wall formation. Required for the regulation of cell length. Plays critical roles for the survival of the pathogen inside the host. Required for both bacterial survival and formation of granuloma structures in a guinea pig infection model.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peptidoglycan D,D-transpeptidase PbpA
- Serine/threonine-protein kinase PknB
- Serine/threonine-protein kinase PknA
- Penicillin-binding protein PbpB
- Serine/threonine protein phosphatase PstP
- Cell division protein FtsQ
- Cell division protein FtsZ
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- FHA domain-containing protein FhaB
- Cell division protein SepF
Sequence:
MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQDQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPITAAGTEVIERV
Protein: Small ribosomal subunit protein eS7 (40S ribosomal protein S7) (S8) (P62083)
Organism: Rattus norvegicus (Rat)
Function: Required for rRNA maturation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P62081}. Cytoplasm {ECO:0000250|UniProtKB:P62081}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62081}. Note=Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. Colocalizes with NEK6 in the centrosome. {ECO:0000250|UniProtKB:P62081}.
Interaction partners:
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS3
Sequence:
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
Protein: Kinesin, putative (Q387X4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin, putative
- Kinesin, putative
Sequence:
MCDRLNTMSIISPRSAAPSSGRRLSASRRGQDREYRRTNSSRSVLSQRQKLSDSIHGTGNAMDVYVRVRPFSERELSMNAPQHSTVRIEVDNPCVLTLLDPQKDFKPRQSYSFTRCFWSVLESDSADCGNAGDILSAIGTYIDRRVASPRSNRQRQATGNSSRSHSARGKGSGDFSGFVETSGSNAALLTVNTVPHPPYSSQADVYNEVGRPLLENSLLGYNGCIFAYGQTGSGKTFTMLGYTPKASDFRRSSRRQQISIDEADGEHLFNSSSPRRTATPLTSNRLRRTSWKSNMVSPRDTRSLSGTFRVEAEQSGAGDDNKPSVDPNELQGIIPRITRDLFQGLHEVRHREASHSFRVELEFYEIYNEKVYDLINPQKDADLKIRQNPLTGPYVEGLSSLVVVNEVQVAEVINRGSVDRHTSCTRMNDRSSRSHAIITINILQLSLDGKNSSCQKRSKLNLVDLAGSERIGATGVEGLHFKESTKINLSLTTLGRVIDCLAELSQSKVPSVTAPYRDSNLTWLLMDSLGGNSKTSMVATISPHCSNFEEMRQTIRYASRARQIVNVAVVNEDPHVRQINMLTNEVENLKKVIRENGMNEFTRDYVIDLRQRYSDLEKRCVEQQLSLVQLRAEIEENTTYNRQDEPTPVSGRATRVFRADLNGRRTRNNVNGDEADALTVSPRVPESRRSAAAAWPTPPKSSPCNNTSRNSNAEVTAELRTQIKRLKDELNTVRVDSCLQQYHVKEFALSYTTAVSNAICDTVIKKNKEFLDQATLLFGTRAGRRDPHLRPLSRTPRRDVDDSKKVPDCRSWRPADKAENDSRCVTPSRAGKAKRGDPDAALAIECAKYQTELQRVRDELGSAIVESQRTSEVLRRLQYEREDLKRKNEEISSKYEEKDREVRQLKRLLESGARSREEGEGGVGSATDWKKQADEELNCLRAALQKICEEHSRVEQQHQAEIHSLISQQDRLFNISSSLLANWESRSAALDSSFAQLRALLHNKEYQSQHQRLRDSMLERRNYSAEVAAVDERKRRDTQRLREIMEQLKQNQKDSKASIQKFEEDVRQHFSGVRTAREGNGGESSFANPHSSRPR
Protein: Uncharacterized protein YjeI (P0AF70)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Inner membrane transporter YjeM
Sequence:
MHVKYLAGIVGAALLMAGCSSSNELSAAGQSVRIVDEQPGAECQLIGTATGKQSNWLSGQHGEEGGSMRGAANDLRNQAAAMGGNVIYGISSPSQGMLSSFVPTDSQIIGQVYKCPN
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Q9FGK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- At2g31490
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- Uncharacterized protein At2g27730
- NADH dehydrogenase 1 beta subcomplex subunit 2
- Transmembrane protein
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- Excitatory amino acid transporter
- NADH dehydrogenase 1 beta subcomplex subunit 3-A
Sequence:
MAGRLSGVASRIMGGNGVVARSVGSSLRQRAGMGLPVGKHIVPDKPLSVNDELMWDNGTAFPEPCIDRIADTVGKYEALAWLSGGLGFFVGLGLLAVLNDKASKVPFTPRVYPYDNLRVELGGEP
Protein: Structural maintenance of chromosomes protein 5 (Q8T386)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGDRALSSKQLAGRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYIQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLVKKQKRLEQVTKCVDEVQNFNSYLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDVSSYEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRCSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGILILNSVLCILGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKDFDSYGIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPKLLRDLNYNEHLCVSIVHNSKTVCHGMQFPMA
Protein: Histone-lysine N-methyltransferase, putative (EC 2.1.1.43) (Q8IDE8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- SET domain protein, putative
- Histone H3
- Histone H3
Sequence:
MFKIEYKEDRGKCVVAVNQIRAGYCLVESHPEIFIPLCVKYMAPRIIDQNNKKNNFKIINTCFYCLEKFNKCICCPNCKYVVYCSDMCLERAWKSHREECDIFRSNIFDRYCPSITMRLVINCYLNHFNFYDYCGSSTDISKEKYERLKYPAYVVAVALMSKRKKIFHNFDNNESILKNIIEKFIKISKNSLQIIDNELEPAGLAIYKKPVPFFNHSCLSNCVTVFRNQKLYIRTLMDVYPGEELTISYIDIAFDRCTRLSICMDQYFFTCSCKLCKVNIASECHNIFNTEIVCTNSENCKKFLGYMEIVLISELERKQCYINKSSFKTYPVLRKSNIDNVWRCMLCKAEVGDNIIKGLVDKEKETFKETVYLETLFNEKYTYDNKSVLQSLNKIKSKIDYLTNYYHHAKYSLQKMRAKILYISIQLHEFKLAYNIANQYLKSIEVSYGKYSPIYGYYIFLTGKLALFLDLKNEGLGLIHKAKKNIIKTYGPDSLIYKDLEKFLYTNKY
Protein: Uncharacterized protein (Q389Y0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTAGLVSSFGRCGGAAAALSTVLHTRQPLPFVFFTKWAMHDFHTSRWSRARSDSQLRRTHLGRKCTETPMMEMVSVNRYGGNAKREALALAFRTYRSVCQSSETLQAGREAVSQVQLDDFAFGDDEMEEVATDFACLYLNATVLFVSPPSEEMMVGLLSCLSKVLHNSFHWECVLSVLVALLHPEATSARVFVTAFTMMLRESLGESVPKTFSRDGVVLLLLSVARATAILRENEASSKDMVYLLALQQNALVELCCTPGAAPLPREELLVLTDAICWRFAATGGCLHLREPSLDSVVKQLQLSSKAVLDVLVVSECTKLFCASCLALVPPSSEGNPRPQCQHQWQTTLDPLVSHLDRLVRVHSIVDALCVFVGLSVNGDARARYRKYPLALLEHLQEEQDVGNIFTELLRSGGSDVFAALTSTLTELRNSGEDDLADAVSPLLNALSTEVPRAAASSS
Protein: Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97) (P79398)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Interaction partners:
- Eukaryotic translation initiation factor 4E
- Eukaryotic initiation factor 4A-I
- RNA helicase
- RNA helicase
- Eukaryotic translation initiation factor 4 gamma 1
- Eukaryotic translation initiation factor 4 gamma 3
- Eukaryotic translation initiation factor 4B
- RNA helicase
- Eukaryotic translation initiation factor 3 subunit B
- YTH domain-containing family protein
Sequence:
MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLQDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVKEMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIGTSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
Protein: Flavone 3'-O-methyltransferase 1 (OsOMT1) (EC 2.1.1.42) (Acetylserotonin O-methyltransferase COMT) (EC 2.1.1.4) (Caffeate O-methyltransferase 1) (OsCOMT1) (EC 2.1.1.68) (OsCOMT) (Quercetin 3'-O-methyltransferase 1) (Q6ZD89)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Methylates OH residues of flavonoid compounds. Can methylate eriodictyol, luteolin, quercetin and taxifolin. Methylates caffeate to produce ferrulate. Catalyzes the methylation of monolignols, the lignin precursors. Functions cooperatively with CAD2 in the culm internodes for the biosynthesis of monolignols. May be involved in lignin biosynthesis in leaves and roots. Involved in syringyl lignin biosynthesis. Can function as 5-hydroxyconiferaldehyde O-methyltransferase in the biosynthetic pathway to syringyl lignin (Ref.16). Involved in melatonin biosynthesis. Can function as acetylserotonin O-methyltransferase. Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26276868}.
Interaction partners:
- Probable inactive methyltransferase Os04g0175900
- Os04g0175600 protein
- Os04g0176200 protein
- Cinnamyl alcohol dehydrogenase 2
- 4-coumarate--CoA ligase 2
- Os01g0688200 protein
- Hydrolase, alpha/beta fold family protein, putative, expressed
- Os02g0207900 protein
- Os01g0837200 protein
- Os01g0315700 protein
Sequence:
MGSTAADMAAAADEEACMYALQLASSSILPMTLKNAIELGLLETLQSAAVAGGGGKAALLTPAEVADKLPSKANPAAADMVDRMLRLLASYNVVRCEMEEGADGKLSRRYAAAPVCKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDARFNRVFNEGMKNHSVIITKKLLDLYTGFDAASTVVDVGGGVGATVAAVVSRHPHIRGINYDLPHVISEAPPFPGVEHVGGDMFASVPRGGDAILMKWILHDWSDEHCARLLKNCYDALPEHGKVVVVECVLPESSDATAREQGVFHVDMIMLAHNPGGKERYEREFRELARAAGFTGFKATYIYANAWAIEFTK
Protein: Hyccin 2 (Q8IXS8)
Organism: Homo sapiens (Human)
Function: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYI3}. Cell membrane {ECO:0000250|UniProtKB:Q9BYI3}.
Interaction partners:
Sequence:
MLGTDRCVVEEWLSEFKALPDTQITSYAATLHRKKTLVPALYKVIQDSNNELLEPVCHQLFELYRSSEVRLKRFTLQFLPELMWVYLRLTVSRDRQSNGCIEALLLGIYNLEIADKDGNNKVLSFTIPSLSKPSIYHEPSTIGSMALTEGALCQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPRQHEKHWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDSTQEGQKVLKVEVTPTVPRISRTAITTASIRRHRWRREGAEGVNGGEESVNLNDADEGFSSGASLSSQPIGTKPSSSSQRGSLRKVATGRSAKDKETASAIKSSESPRDSVVRKQYVQQPTDLSVDSVELTPMKKHLSLPAGQVVPKINSLSLIRTASASSSKSFDYVNGSQASTSIGVGTEGGTNLAANNANRYSTVSLQEDRLGQAGEGKELLSPGAPLTKQSRSPSFNMQLISQV
Protein: Proline-serine-threonine phosphatase interacting protein 1 isoform 1 (A0A0S2Z5P3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMPQLQFKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTEINSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEKL
Protein: Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein) (Q9Y4X0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:27811305}.
Interaction partners:
- Long-chain-fatty-acid--CoA ligase 4
- Potassium voltage-gated channel subfamily E regulatory beta subunit 5
- Collagen alpha-5
- NTF2-related export protein 2
- Retinal guanylyl cyclase 2
Sequence:
MAAGCCGVKKQKLSSSPPSGSGGGGGASSSSHCSGESQCRAGELGLGGAGTRLNGLGGLTGGGSGSGCTLSPPQGCGGGGGGIALSPPPSCGVGTLLSTPAAATSSSPSSSSAASSSSPGSRKMVVSAEMCCFCFDVLYCHLYGYQQPRTPRFTNEPYPLFVTWKIGRDKRLRGCIGTFSAMNLHSGLREYTLTSALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYLDWEVGVHGIRIEFINEKGSKRTATYLPEVAKEQGWDHIQTIDSLLRKGGYKAPITNEFRKTIKLTRYRSEKMTLSYAEYLAHRQHHHFQNGIGHPLPPYNHYS
Protein: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase) (O75752)
Organism: Homo sapiens (Human)
Function: Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development (By similarity).
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein.
Interaction partners:
- Lactosylceramide 4-alpha-galactosyltransferase
- Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
- Alpha-1,3-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 4
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- Alpha-N-acetylgalactosaminidase
- Beta-1,4-galactosyltransferase 1
- Beta-hexosaminidase subunit alpha
- Alpha-galactosidase A
Sequence:
MASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDFHFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYNNLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGYIMSRDLVPRIYEMMGHVKPIKFEDVYVGICLNLLKVNIHIPEDTNLFFLYRIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY