wanglab/gogpt-training-data huggingface dataset:
Protein: Hamartin (Tuberous sclerosis 1 protein homolog) (Q9Z136)
Organism: Rattus norvegicus (Rat)
Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity).
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q92574}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92574}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q92574}. Note=Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients. In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol. {ECO:0000250|UniProtKB:Q92574}.
Interaction partners:
- TBC1 domain family member 7
- Tuberin
- GTP-binding protein Rheb
- RAC-alpha serine/threonine-protein kinase
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Serine/threonine-protein kinase mTOR
- Glycogen synthase kinase-3 beta
- DNA damage-inducible transcript 4 protein
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
Sequence:
MAQLANIGELLSMLDSSTLGVRDDVTTIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKMNEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENVETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKTLETHDVVIECAKISLDPTEASYEDGDAVSHQLSACFPHRSADVTTSSYVDTQNSYGGATSTPSSTSRLMLFSTPGQLPQSLSSLSTRPLPEPLQASLWSPSAVCGMTTPPTSPGNVPADLSHPYSKAFGTTTGGKGTPSGTPATSPPPAPPCPQDDCAHGPASQASATPPRKEERADSSRPYLPRQQDVPSDRGLEDLPGSKGSVTLRNLPDFLGDLASEEDSIEKDKEEAAISKELSEITTAEADPVAPRGGFDSPFYRDSLSGSQRKTHSAASGTQGFSVNPEPLHSSLDKHGPDTPKQAFTPIDPPSGSADASPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQLPPYDHLFEVALPKTACHFVSKKTEELLKKAKGNPEEDCVPSTSPMEVLDRLLEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYSQLQQQRDTMVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRSMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQSKHPDTTKEVEMMKTAYRKELEKNRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKITRVLELEILDLYGRLEKDGRLQKLEEDRAEAAEAAEERLDCCTDGCSDSLLGHNEEAAGHNGETRTSRPGGTRASCGGRVTGGSSSSSSELSTPEKPPNQRFSSRWEPTMGEPSSSIPTTVGSLPSSKSFLGMKTRELFRNKSESQCDEDGMTMSSFSETLKTELGKDSAGMENKTPPSLDAPHPSSPSSDSMGQLHIMDYNETHHEHS
Protein: CD209 antigen-like protein E (DC-SIGN-related protein 4) (DC-SIGNR4) (CD antigen CD209) (Q91ZW7)
Organism: Mus musculus (Mouse)
Function: Putative pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Intercellular adhesion molecule 2
- Lymphocyte-specific protein 1
- Butyrophilin subfamily 2 member A2
- CD209 antigen-like protein D
- Scavenger receptor cysteine-rich type 1 protein M130
Sequence:
MRAPQMGSLGFLDKGHIPLVLQLLFLILFTGLLVAIIIQVSKMPSSEEIQWEHTKQEKMYKDLSQLKSEVDRLCRLCPWDWTFFNGNCYFFSKSQRDWHDSMTACKEMGAQLVIIKSHEEQSFLQQTSKKNSYTWMGLSDLNKEGEWYWLDGSPLSDSFEKYWKKGQPNNVGGQDCVEFRDNGWNDAKCEQRKFWICKKIATTCLSKW
Protein: Roundabout 1, isoform A (Roundabout 1, isoform C) (Q9W213)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Protein slit
- Protein commissureless 1
- Protein son of sevenless
- Tyrosine-protein kinase Abl
- Dreadlocks, isoform B
- Roundabout 2, isoform B
- receptor protein-tyrosine kinase
- FI24025p1
- Syndecan
- Rho GTPase-activating protein 39
Sequence:
MHPMHPENHAIARSTSTTNNPSRSRSSRMWLLPAWLLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVSTNEKKSHRVQFKDGALFFYRTMQGKKEQDGGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYHNNGNIPPGDINPTTHKKTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVVSDNEITALNINSKESLWIDHHRGWRTADTDKDSGLSESKLLSHVNSSQSNYNNSDGGTDYAEVDTRNLTTFYNCRKSPDNPTPYATTMIIGTSSSETCTKTTSISADKDSGTHSPYSDAFAGQVPAVPVVKSNYLQYPVEPINWSEFLPPPPEHPPPSSTYGYAQGSPESSRKSSKSAGSGISTNQSILNASIHSSSSGGFSAWGVSPQYAVACPPENVYSNPLSAVAGGTQNRYQITPTNQHPPQLPAYFATTGPGGAVPPNHLPFATQRHAASEYQAGLNAARCAQSRACNSCDALATPSPMQPPPPVPVPEGWYQPVHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQSHKRQLQLEEHGSSAKQRGGHHRRRAPVVQPCMESENENMLAEYEQRQYTSDCCNSSREGDTCSCSEGSCLYAEAGEPAPRQMTAKNT
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (O77347)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- UBX domain-containing protein, putative
Sequence:
MSDNIENPRDDNENEDRNNIFLYNNEISNEGSDSCNVLCLFLFFLSLFFIMIISADNNTAHTFSSPTNNNNNNNNNNTDNNDNSNNSNNSNINNKKNYINNNNNHSNYNNYFDDDPSIKYRKNNNIYKDNINDEFLKKEDNDNIMNNMLDNILIQCLHFKGAYKIRNKNNNNMSDGIFEAKLVTLKLALNNVTKSYIFFYFNPYDNNNTNHNIYILNDIPKQYKYLGFNGININKENRYIFNGQGYNISTFCQLKNNVKKKNEAYKYAHTNIYNNNDNNNNNNNNINGVNENCLCNYTININQYINKYESVSLREVDESYLYSLKGYILDEQEYYKNYLQNEYIKLYKNYISYIQKYYHTHYIEKENMIHFHSLGNVNEEIIKHQSKLESAKQNDKELSYVTLKKVKHESGTIPNHNTEREYTSNVDNNDGNNKNNDGNNKNNDENNNNSDGNNNNNDGNNKYNDVNNKYNDVNNKNNDVNNKYNDGHNKNNNEHVTNAHYDGYIYSNNCNLLISFEGIDIDKKYISTKVLNFSILFNIKSIIEISLFWSQIGTSGSIPGASRISLISICLNSLIDIFESLLLLYEVLLSKLLLIHFILMILLKFLLFTIMEVRYVLIVWKANHQHEVNEGWEHMQRKLSKLYKYYYGSIFLLILLFYYVFPFFPYILLILYLCWLPQILLDIWRGQRNSVDIKFVFILSLCRLYLPIYIYLYPHNIFQLDNFSQLIDTSNTMFSILIIFIVFIQCIYMLLQRIYGPRYFVNIDLLPHVHNYYKTIDVNFEAGIPECVICMYDIVLKPNKYCVTPCYHIFHEKCLQQWMDIKLECPTCRGPLPNFS
Protein: Tropomyosin 1 (H0YK48)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Protein: Rab family GTPase (A0A1D8PFT9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34
- Pep7p
- Rab family GTPase
- Rab GDP dissociation inhibitor
- Vacuolar protein sorting-associated protein 45
Sequence:
MSNKQSNQRFAQFKLVLLGESAVGKSSIVHRFVKNTFDDMRESTIGAAFLTQTITIPESETTIKFEIWDTAGQERYKSLAPMYYRNANAALCVYDITSRSSFQKAQDWIKELKKQAPEGIVIALVGNKSDLDDEREVESSEVQEYVQEQNSDGCSIITAECSAKSGDGVLDVFNKIGRALPVDEVIDASRSRQGAGAGGRRPGGVDLNRPRGQVNQSNSCC
Protein: Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) (P53563)
Organism: Rattus norvegicus (Rat)
Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Subcellular location: [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes to the centrosome when phosphorylated at Ser-49 (By similarity). After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. {ECO:0000250}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Beclin-1
- Bcl-2-like protein 11
- Phorbol-12-myristate-13-acetate-induced protein 1
- BCL2 interacting protein 3
- Cellular tumor antigen p53
- Cytochrome c, somatic
- Bcl2-associated agonist of cell death
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- BCL2-antagonist/killer 1, isoform CRA_b.
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (O62609)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
- Mothers against decapentaplegic homolog
- Sno oncogene, isoform B
- Protein mothers against dpp
- E3 ubiquitin-protein ligase Smurf1
- Protein decapentaplegic
- receptor protein serine/threonine kinase
- Protein pangolin, isoform J
- Transcription factor E2F2
- Forkhead box protein O
- Zinc finger FYVE domain-containing protein
Sequence:
MGGGSGACPPAHMYGAVAPQDIIVRDMVQMPPPPSNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPRAAA
Protein: Mitotic spindle checkpoint component mad3 (O59767)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in transducing the anaphase inhibitory signal to the anaphase promoting complex (APC). Forms part of the mad2 feedback control.
Subcellular location: Nucleus {ECO:0000269|PubMed:11909965, ECO:0000269|PubMed:22660415}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11909965, ECO:0000269|PubMed:22660415}.
Interaction partners:
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 3
- Anaphase-promoting complex subunit 4
- Spindle assembly checkpoint protein bub3
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 8
- WD repeat-containing protein slp1
- Mitotic spindle checkpoint component mad2
Sequence:
MEPLDAGKNWVHMDVIEQSKENIEPRKAGHSASALAKSSSRNHTEKEVAGLQKERMGHERKIETSESLDDPLQVWIDYIKWTLDNFPQGETKTSGLVTLLERCTREFVRNPLYKDDVRYLRIWMQYVNYIDEPVELFSFLAHHHIGQESSIFYEEYANYFESRGLFQKADEVYQKGKRMKAKPFLRFQQKYQQFTHRWLEFAPQSFSSNTNSVNPLQTTFESTNIQEISQSRTKISKPKFKFSVYSDADGSGKDGQPGTWQTLGTVDQRRKENNISATSWVGEKLPLKSPRKLDPLGKFQVHCDEEVSKE
Protein: Outer dense fiber protein 2 (84 kDa outer dense fiber protein) (Cenexin) (Outer dense fiber of sperm tails protein 2) (Q6AYX5)
Organism: Rattus norvegicus (Rat)
Function: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15340007}. Cell projection, cilium {ECO:0000269|PubMed:15340007}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15340007}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15340007}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A3KGV1}. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. {ECO:0000250|UniProtKB:A3KGV1}.
Interaction partners:
- Ninein
- Centrosomal protein of 164 kDa
- Centrosomal protein 170
- Centrosomal protein of 170 kDa
- Centrosomal protein of 83 kDa
- Coiled-coil domain containing 120
- Sodium channel and clathrin linker 1
- Fas binding factor 1
- Coiled-coil domain containing 68
- Rab-3A-interacting protein
Sequence:
MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLELAREKHQASQKENKQLSQKVDELERKLEATSTQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDVDRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYTSSYLTSSPIRSRSPPA
Protein: Dynein regulatory complex subunit 3 (Flagellar-associated protein 134) (A8IVX2)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Required for normal flagellar waveform.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
Interaction partners:
Sequence:
MPSLERLIAEVEPNVITESLTRECIQIQGGEPDTAANKKRTMPFRDVECLAFSFKNLACVDNLRGLDTLTKLQLDNNQITKIENLAHLTNLTWLDLSFNKITAISGLETLTKLVDLSLFNNQIAKIENLDTLVNLNVLSLGNNQLSQLDNVMYLRQFKQLRLVNLAGNPICKSHDYRSYVLSHIKDLIYLDYRRVNPADVQAAREQHQDEMIELQEREEQQSQEEKLNAERESHEKLMKQANLEGVETLIDDMVKEDLEWPRLSQVPSLLDPWNEIRDKFNTYTDEFKVAILEQHNKKKAEYEEWLGVVRSYLDEKDAEARKLIVEYEKAKKRTARVVVDQPLMAESQIDNLKVKLMALKDQLMAIEMEAVEVLDGLVQEFDRAYSELAEINKGQYNGYFTQVRDLQNSFFNQLTSVAMTVFEKYNQENSDIESLPEEARTLLQDKDSLMNALQASHDAHMGKIDSLEDRLVSNELRSANDLTSSNATWATKRNRDRISEIINYLERNVLELEELAGEEEGGEM
Protein: Abi_C domain-containing protein (Q9U379)
Organism: Caenorhabditis elegans
Interaction partners:
- Regulator of G-protein signaling 7
- G-protein coupled receptors family 1 profile domain-containing protein
- Regulator of G-protein signaling rgs-7
- Regulator of G-protein signaling rgs-6
Sequence:
MRQHSMANPKKIQELVHECNVQLALFRVATQGIGTAQDGASLRREVETAGRACQKAVEAANNVVLPQLRADEAEIARHGSLFIGCVGAYLIEMKRCVKLEKTFPAPTEPSVTPQQVERVEVILDTLENLITVHYSTNEQPCLDKLQVTPRRRRATSCRPQCVCSKLKTSYA
Protein: Glutamine synthetase (EC 6.3.1.2) (Q8JI33)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Aldehyde dehydrogenase domain-containing protein
- Uncharacterized protein
- Delta-1-pyrroline-5-carboxylate synthase
- Delta-1-pyrroline-5-carboxylate synthase
- Serine hydroxymethyltransferase
- Lengsin
- Succinate-semialdehyde dehydrogenase
- glutamate--tRNA ligase
- Bifunctional glutamate/proline--tRNA ligase
- glutamate--tRNA ligase
Sequence:
MAMSASAELSKAVKQQYMELPQGDKVQVMYVWIDGTGEGLRCKTRTLDSEPKSIEELPEWNFDGSSTYQSEGSNSDMYLIPSAMFRDPFRKDPNKLVLCEVLKYNHKPAETNLRLTCKKVMDLVENQIPWFGMEQEYTILGTDGHPFGWPNNGFPGPQGPYYCGVGSDKAYGRDIVEAHYRACLYAGVMICGTNAEVMPAQWEFQVGPCEGITMGDHLWVARFILHRVCEDFGVVASFDPKPIPGNWNGAGCHTNFSTKEMREEGGLKAIEESIERLGRRHSYHIRAYDPKGGLDNARRLTGHHETSNIHEFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPYAVTEALIRTCLLSEEGDEPVDY
Protein: Trafficking protein particle complex subunit 14 (cDNA FLJ30310 fis, clone BRACE2003431) (B3KNS5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPDGSVLLVDNVCHQSGEVSMGSFCRLPGTSGCFPCPLNALEEHNFLFQLRGGEQPPPGAKEGLEVPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCKSPVRTYERFTVTYTLLNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSVVCHTPLNNLGFSRKGSALTFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERHQASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKIAKRECKVLVVEPVK
Protein: Xylose operon regulatory protein (P0ACI3)
Organism: Escherichia coli (strain K12)
Function: Regulatory protein for the xylBAFGHR operon.
Interaction partners:
- Xylose isomerase
- D-xylose-binding periplasmic protein
- Xylose transport system permease protein XylH
- Xylulose kinase
- Xylose import ATP-binding protein XylG
- D-xylose-proton symporter
- DNA-binding transcriptional regulator NtrC)
- Lactose operon repressor
- Multiphosphoryl transfer protein 1
- Multiphosphoryl transfer protein 2
Sequence:
MFTKRHRITLLFNANKAYDRQVVEGVGEYLQASQSEWDIFIEEDFRARIDKIKDWLGDGVIADFDDKQIEQALADVDVPIVGVGGSYHLAESYPPVHYIATDNYALVESAFLHLKEKGVNRFAFYGLPESSGKRWATEREYAFRQLVAEEKYRGVVYQGLETAPENWQHAQNRLADWLQTLPPQTGIIAVTDARARHILQVCEHLHIPVPEKLCVIGIDNEELTRYLSRVALSSVAQGARQMGYQAAKLLHRLLDKEEMPLQRILVPPVRVIERRSTDYRSLTDPAVIQAMHYIRNHACKGIKVDQVLDAVGISRSNLEKRFKEEVGETIHAMIHAEKLEKARSLLISTTLSINEISQMCGYPSLQYFYSVFKKAYDTTPKEYRDVNSEVML
Protein: Serine/threonine-protein kinase D6PKL3 (EC 2.7.11.1) (D6 protein kinase-like 3) (Serine/threonine-protein kinase AtPK7) (Q05999)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein kinase that regulates the auxin transport activity of PIN auxin efflux facilitators by direct phosphorylation. D6PK-mediated PIN phosphorylation promotes auxin transport in the hypocotyl and this is a prerequisite for PHOT1-dependent hypocotyl bending.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with PIN1 to the basal (lower) membrane of root cells. {ECO:0000250}.
Interaction partners:
- Protein INAPERTURATE POLLEN1
- Peptidyl-prolyl cis-trans isomerase Pin1
Sequence:
MDSSSSVVYVGSSSKSRNFQSKSKGSITSFSIDSRGTKKSMKTLLIPEPEPTSPEVIESSVSSVSAESETPISIIRKKKQSEPRFYSSPTNTFYTEAKQSFTNTEFSECASISTIGIGGIDLEKNGVMIYRGSIGSDVSDESSSSGLSNAAYKPHRDNNDKRWVAIQEVRSRVGSSLEAKDFKLIKKLGGGDIGNVYLAELIGTGVSFAVKVMEKAAIAARKKLVRAQTEKEILQSLDHPFLPTLYSHFETEMNSCLVMEFCPGGDLHSLRQKQRGKYFPEQAARFYVAEVLLAMEYLHMLGIIYRDLKPENVLVREDGHIMLSDFDLSLRCAVSPTLVRFAAITLESKSSSYCIQPTCVDQSSCIVQPDCIQPVCFTPRFLSKGKHRKKSNDMSRQIRPLPELIAEPTSARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGITPFRGGDNRATLFNVVGQPLRFPEHPNVSFAARDLIRGLLVKEPQHRLAYRRGATEIKQHPFFQSVNWALIRCTSPPQIPQPVKPMDQAHSVRHGFSQGHGHVGYDKPPTVDVKPSGNYLEIDFF
Protein: 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) (O54950)
Organism: Mus musculus (Mouse)
Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity).
Interaction partners:
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- 5'-AMP-activated protein kinase subunit beta-1
- 5'-AMP-activated protein kinase subunit beta-2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- Calcium/calmodulin-dependent protein kinase kinase 2
- Serine/threonine-protein kinase STK11
- 5'-AMP-activated protein kinase subunit gamma-2
- 5'-AMP-activated protein kinase subunit gamma-3
- Regulatory-associated protein of mTOR
- Acetyl-CoA carboxylase 1
Sequence:
MESVAAESSPALENEHFQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLQELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALVLTGGEKKP
Protein: At2g44240/F4I1.5 (Expressed protein) (NEP-interacting protein (DUF239)) (O64859)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 18
- Regulator of Vps4 activity in the MVB pathway protein
- Dirigent protein 23
- Cyclin-D4-2
- Protein RALF-like 30
- Gibberellin 20 oxidase 5
- Nematode resistance protein-like HSPRO2
- Probable pectinesterase/pectinesterase inhibitor 17
- GDSL esterase/lipase 1
- UDP-glycosyltransferase 72E2
Sequence:
MMGVAGFAVALMVTSLLIATCADGKEFFHHREIKVQRFLKQLNKPALKSIKSEDGDIIDCVLITSQPAFDHPLLKNHTIQVKPSFIPEGEGDSTYTKKETKATQVWQKYGECPENTIPIRRTKKEEILRAKSLESFGKKNHQYIPEDTSSPNYHHEYAFMGVRNGKFYGTKASINVWKPDVATPSEFSLSQTWIVSGDGTSRNTIEAGWQVYPGMYGNNDPRLFVYWTSDGYQKTGCYNLVCGGFVQTTNQYTVGGSYVTASQYDGAQLVLNLLIWKDPKTGNWWLKINDNDVIGYWPGSLFNSLGDGAIKVEWGGEIFAPTSDRHTTTDMGSGHFAEEGIKKASYVKNIMIVDGTNALREPQGLYSYADNRNCYSVVPGNAGTSFGTHFFYGGPGQNVKCP
Protein: UPF0213 protein SP_1535 (Q97PR7)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MDHKAYMYVLECRDGSYYIGYTTDMRRRLAIHNSGKGAKYTRARLPVKLIYAQGFASKEEAMSAEALLKRKKRPQKEEFLSENQDRNLLSYFEESWGVL