wanglab/gogpt-training-data huggingface dataset:
Protein: DNA topoisomerase 2 (EC 5.6.2.2) (Q1LUT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Structural maintenance of chromosomes protein
- DNA topoisomerase I
- Condensin complex subunit 2
- Proliferating cell nuclear antigen
- DNA topoisomerase I
- Putative deoxyribonuclease tatdn3
- TatD DNase domain containing 3-like
- DNA topoisomerase I
- Structural maintenance of chromosomes protein
- Baculoviral IAP repeat-containing 5a.
Sequence:
MSNGAAGSGGLTWVTLFDKNNGAKKEEMNGRGDAGKSEVVKKESSKKMSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNLREISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDNEKKVTGGRNGYGAKLCNIFSLKFTVETACKEYKRSFKQTWTENMGKSNEAKIKYFDGEDFTCVTFQPDLAKFNMEKLDKDIVALLTRRAYDVAGSCRGVKVILNGKKLPVNSFRSYVDFYVKDKLDETGVALKVVNETVNERWEVCLTMSEKGFQQISFVNSIATTKGGRHIDYIVDQIVGKLIEVVKKKNKAGVSVKPFQVKNHLWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKILGLQYKKSYDDPESLKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSSLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGTIHELGQNQYLVSGEVSVLDKNTIEISELPVRTWTQAYKESVLEPMLQGTDKTPPLISDYKEYHTDTTVKFVVRMTEEKLAQAEAAGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQEILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKLSIENKSKRDLIRMLVQRGYESDPVAAWNKAQEKSLEEEDGGGNDSDSSVDSGSFSGPNFNYILNMPLWCLTKEKVEELLKQRDLKKAELNELQSKTSENLWREDLAVFIEELDRVEEQEKESVNLGKAVKLVKGKVGKPKVKKMQLEETLPSPFGRRVEPQITLAMKADASKKLTKKKKGEIDAAVKLEIDDDSALGSNGGENSLISPSGLPNPGAKPKAPRVKREKKEPGTPRQRKPAGAKGPAKKVKKRNPWSDDDEGGDDDRSDIELDECEPVIPRDSTSRRASAVKAKYTFDFSEEEEEEEDGDEEQENDASASPVHSFKNTEQHDDEVDDDDDIFPPKTTFTLPTSTAKKKNPEPVLPSKTTYDDKISDDDMKSDSDGDRGPVFSSYSSSSAFEKPAKKTAKKPVDTPPKPKKAPVKAKKPDTSVWDSDSDTGTKKPPASKGSGKGRSKKRKQSSLEEDEYSPMKKHGKSATSRKPKKAASDDEDDDDDDETGFNSFSHLDSGRDRSGRAKKEVKYFAESDNDDDDDMFD
Protein: Transmembrane protein 127 (O75204)
Organism: Homo sapiens (Human)
Function: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}; Multi-pass membrane protein {ECO:0000269|PubMed:20154675}. Cytoplasm {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}.
Interaction partners:
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Succinate dehydrogenase assembly factor 2, mitochondrial
- Succinate dehydrogenase assembly factor 2
- Neurofibromin
- Kinesin-like protein KIF1B
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Protein max
Sequence:
MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEPYPAEYEVINQFQPPPAYTP
Protein: Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20) (EC 3.1.3.48) (Q4JDL3)
Organism: Homo sapiens (Human)
Function: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
Subcellular location: Nucleus {ECO:0000269|PubMed:15790311}. Cytoplasm {ECO:0000269|PubMed:15790311}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15790311}. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.
Interaction partners:
- FERM and PDZ domain-containing protein 2
Sequence:
MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKVFENKVNSEKVKLSLRNFPHNDYEDVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAAGPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLTLD
Protein: Beta-carotene 4-ketolase (PbBKT) (EC 1.14.99.63) (G3F5K2)
Organism: Protosiphon botryoides (Green alga)
Function: Involved in the biosynthesis of ketocarotenoids which are powerful anti-oxidative molecules. Catalyzes the conversion of beta-carotene to canthaxanthin via echinenone.
Interaction partners:
Sequence:
MPHSIDMEDSSAIAERSKHAGLALEPEACFNLPQPTAEDRQDNWQTQYHSSEGAQGGSRKAQAADATTGNPTVDDASQQNGLLQQWVKQGYFMPAEHGSKAGNDVKHKYSPPKSDVWGVLVACTVITTWAALFYHSIFQIKLPSIEQLRSGNYNPSDFTSWPHVLLAFFSLEFLYTGLFITTHDAMHGTIAMRHRKLNDFLGSFAISLYAWFDYKMLHKKHWEHHNHTGKVGADPDFHRGNPSILPWFARFMMEYSSLWQFAKIAWWATGMQLLGAPFQNILMFMTAAPILSAFRLFYYGTYIPHHPEPGPASDKVEMDWTMSRTSTAPSLLSFLTCYHFDLHWEHHRWPYAPWWQLPVCRKLAGRTNPLHTEALQTAEPSRLEHGG
Protein: Ubiquitin-like modifier-activating enzyme 1 (EC 6.3.2.19) (Q6P9P3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSSPLSKKRRVSGSETKTGSHCSSSNSVRTELSHTPANGMAKNGNDAEIDEGLYSRQLYVLGHDAMKRMQSSNVLISGLRGLGVEIAKNVILGGVKSVTLHDQGVAEWKDLSSQFYLREEDLGKNRADVSQPRLAELNSYVPVTSYTGTLTNEYLTKFQVVVLTNSSLDEQTRIGEFCHSNGIKLIVADTRGLFGQLFCDFGEVMIVFDTNGEQPLSAMISMITKDSAGVVTCLDEARHGFESGDYVTFTEVQGMTELNGCDPVEIKTLGPYTFSICDTSSFSDYVRGGIVTQVKMPKKIAFKSLSSSMAEPEFLLTDFAKFDRPGQLHVGFQALHAFEKKHSRLPKPWNQADADELMTLAEEVNAAQTGSAKQEELDQAVIKKLACVAAGDLAPVNAFIGGLAAQEVMKACTGKFMPIMQWLYFDALECLPEPEEVILTEEECAPRNCRYDGQIAVFGSKLQELLAKQRYFLVGAGAIGCELLKNFAMMGLASGEGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSETAAAAVKQMNPSVRITGHQNRVGPDTEKVYDDDFFECLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFITESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENALQYLTDSKFMERTLKLPGAQPLEVVESVYKSLVTDRPRNWDDCVTWARNHWQCQYNNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLEFSTNNDLHMDYILAAANLYALSYGLPSCNDRSALTKLLQDIKVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKTLLPSLEASSQFKLCPIEFEKDDDTNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELLKIVQGHKKLESYKNGFMNLALPFFAFSEPIAAPKHKYYEIDWTLWDRFKVKGIQPNGEEMTLRQFLDYFKNEHKLEITMLSQGVSMLYSFFMPAAKLKERLELPMTEIVTKVSKKKLGKHVKALVFELCCNDDTEEDVEVPYVRYTIR
Protein: Protein THO1 (P40040)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Unknown; suppressor of the transcriptional defect of HPR1 by overexpression.
Interaction partners:
- ATP-dependent RNA helicase SUB2
- RNA annealing protein YRA1
Sequence:
MADYSSLTVVQLKDLLTKRNLSVGGLKNELVQRLIKDDEESKGESEVSPQEQNQEQGSEPAAIEEPASQNITEKKEVSSEPKETNEPKEENKDVQKPSDGPSATASENEQAAASTAAPALSPEEIKAKALDLLNKKLHRANKFGQDQADIDSLQRQINRVEKFGVDLNSKLAEELGLVSRKNEPESGNNGKFKNRNKNANNRSRVSKNRRGNRSGYRR
Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (P52029)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase
- Enolase
- Phosphoglucomutase 1
- Pyruvate kinase
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Phosphoglycerate mutase
- Probable transaldolase
- Phosphoglycerate kinase
- transketolase
Sequence:
MAGPLPPLNQEAAFQKLQEYYDSKGKDLNIKDLFVKDSKRFSKYSLRLHTQNDGEILLDYSKNRINDEVWDLLLTLAKVRRVNAARDAMFSGQHINITENRAVLHTALRNRGTDPVLVDDKDVMPDVRAELAHMKEFTNMVISGVWRGCTGKQITDVVNIGIGGSDLGPLMVTEALKPYGKGLHSHFVSNIDGTHLAEVLKKVNYETTLFIVASKTFTTQETITNATSAKTWLLEHSKEPESVAKHFVALSTNKEKVTEFGIDSTNMFGFWDWVGGRYSLWSAIGLSICLSIGFENFEQLLDGAHFMDNHFKTTPFEKNAPVILALLGVWYSNFFKAETHALLPYDQYLHRFAAYFQQGDMESNGKFVSKSGKPVKYSTGPIVWGEPGTNGQHAFYQLIHQGTRLIPCDFIAPAQTHNPIAGGKHHKILLSNFLAQTEALMAGKTVDEARTELSKAGLCGNELDNLLPHKVFVGNRPTNSIVVKKVSPFTLGALIALYEHKIFVQGIIWDINSFDQWGVELGKQLAKAIEPELDHCNEVSTHDSSTNGLINFIKANWK
Protein: WASH complex subunit 5 (WASH complex subunit strumpellin) (Q8C2E7)
Organism: Mus musculus (Mouse)
Function: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q12768}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q12768}. Early endosome {ECO:0000250|UniProtKB:Q12768}. Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. {ECO:0000250|UniProtKB:Q12768}.
Interaction partners:
- WASH complex subunit 2
- WASH complex subunit 4
- WASH complex subunit 3
- WASH complex subunit 1
- Sorting nexin-27
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha-1
- Vacuolar protein sorting-associated protein 35
- DnaJ heat shock protein family
- FK506-binding protein 15
Sequence:
MLDFLAENNLCGQAILRIVSCGNAIIAEVLRLSEFIPAVFLLKDRADQQRYGDIIFDFSYFKGPEFWESKLEAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLSEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGAKRPPNYPESYFQRVPINETFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLADAWEPYKAAKTALNNTLDLANVKEQASRYASVSDRVRAQVQQFLKEGYLREEVLLDNIPRLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILADSRYNPKILFQLLLDTAQFEFILKEMFKQMLSEKQSKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITVQIIGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIMEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFAPVDESITFIGRLCREILRITDPKMTCYIDQLNTWYDVKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILKERTVQETLKMLMSAVNPLKSIVANSSKVYLSAITKTQKIWSAYLEAIMKVGQMQILRQQIANELNSSCRFDSRHLAAALDNLNKALLADIEAHYRDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPADPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSTMEQCTSQKMPEMPADAVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL
Protein: Mono-ADP ribosylhydrolase 2 (A0A2R8YFN3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSEGLEPKGLSPPYKKSKAKKPECSKDSSEDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK
Protein: Lactoperoxidase (LPO) (EC 1.11.1.7) (P80025)
Organism: Bos taurus (Bovine)
Function: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (Probable). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (Probable). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism. The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against some streptococci strains. The lactoperoxidase-I(-)-H2O2 system shows antibacterial properties against E.coli. May protect the udder from infection and may promote growth in newborns (By similarity). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:2050150}. Cytoplasm {ECO:0000250|UniProtKB:Q5SW46}.
Interaction partners:
- Alpha-lactalbumin
- Lactotransferrin
- Beta-lactoglobulin
- Albumin
- Kappa-casein
- Beta-casein
Sequence:
MWVCLQLPVFLASVTLFEVAASDTIAQAASTTTISDAVSKVKIQVNKAFLDSRTRLKTTLSSEAPTTQQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN
Protein: TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (X6RGC9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK
Protein: Protein Aatf (Apoptosis antagonizing transcription factor ortholog) (Q9VM95)
Organism: Drosophila melanogaster (Fruit fly)
Function: May function as a general inhibitor of the histone deacetylase HDAC1.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nucleolar protein 10
- RNA cytidine acetyltransferase
- FI04466p
- LD31322p
- Nucleolar protein 14 homolog
- FI03455p
- LD41718p
- LD38375p
- U3 small nucleolar RNA-associated protein 18 homolog
- DDB1- and CUL4-associated factor 13
Sequence:
MLRKSKKQPQTVAEKVSKLLAHPNESDSAEDSDFDVATGPRLVDFEEEEYDLPDARSTDFRKRNVKLLSEQSDRYKGKISSRKELDDDEDKDDEQEVSYEESDEDDENLTNFKQKLNAGGAEDSEEETAAGHSESGEESEEIESNLTDFKKKFEAGDFKYDDDEEEDDDSEEEDHSQESEGDDDDSEDDEAEDDAIKPSDVMSKTNHQAEIQKGLAVQNQLRIWERLLELRINTQKFTSKANQLPAPETLTKLASESDELQSVLNEAQERSSKLLQQLLSLQSALHQQYSEMKKSVKRKQPTEDSGPAVKKFGSVLQSNFQQMIGYRNEVLLKWDDRTKLLTPGAGVKRKSLQEDYDIIKKIGSALANREALVEKSQTPKNSQAEQQENTPVQRLKHIYDDSDFYHQQLRELIEYKASTSSNMSEITKQFVELQKLRQKMKKKVDTRASKGRKLRYVVHNKLINFMAPNESSDWTDASKSELYKSLFV
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (F1QWX8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription.
- Leptin receptor.
- Suppressor of cytokine signaling 3
- Suppressor of cytokine signaling 3
- Tyrosine-protein phosphatase non-receptor type
- Signal transducer and activator of transcription
- Tyrosine-protein phosphatase non-receptor type
- Signal transducer and activator of transcription.
Sequence:
MMLANTENEQKQASGAALQVRLYCCRDGAGVISYPAGEYTAEELSVTAAKQCGVSPVHCALFGLMRERDRVWLPPNHIFKIEPSANETLLFRVRFYFPGWYGSGCSSARRYGLSRSSEAPVCDDITTAYLCAQWRSDFLSGAVSVPVSLEFQEECLGLAVLDIMRLAKEKGKSPVDIYNHSSYKSFLPKNMREHIQNQHLVTRKRIRFRFRRFLQQFGSCKAAPRELKLKYVVSLETLQPAFYSEHFRVSEASAGSVTIVVSGDRGIQWCRAAAPEPEDLQVYCDFSDVIDISIKQGTKDGSVENRIVTINRQDSQTLELEFQSLSEALSFVSLIDGYYRLTTDAHHYLCKEVAPPRLLEAIQINCHGPLSTEFAVSRLRRCEGQPGVYILRCSPKDYDRYFLSFMVEAEGQLELKHCLVLRSLSGEFVLSGARCSFSSLSELLARYQKEALRSDTHVFQLRRCCPPRSKDKSNLLVCRTHQGSEVCAPSSEHRLVNQMIFHKIHREDLQTTEGLGQGTFTQVFRGIRREVGDYGEVHKMEVVMKILDKSHRNYTESFFESASMMSQLSHKHLLLNYGICVCADEHIMVQEYVRFGSLDTYLKRNRNTINITWKLEVAKQLAWALHHLEEKSLTHGNVCARNVLVTREEDRKTGTPPFIKLSDPGISITVQPREILLERIPWVPPECVKDSRNLSLAADKWSFGTTLWEIYCGGEQPLAAYDTAKKLLFYEDKHQLPAPKWTELASVINSCMDYEPLHRPSFRALIRDLNSLYTPDYELLVESDTVPSRHRGPGLAGAFESQEPTQFQARHLIFLQLLGKGNFGSVEKCRYDPLQDNTGEVVAVKKLQHSTAEHLRDFEREIEILRSLQHENIVRYKGVCYSAGRNNLRLVMEFLPFGSLRDYLSKNRERFDHSKLLLYASQICKGMDYLAEKRYVHRDLATRNILVESEFRVKIGDFGLTKVLPQDKEYYTVREPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYSEKSCSPPAVFMEQMGEDKQGQMIVYHLIDLLKRNYRLPAPDGCPAEIHALMKQCWAPEPADRPLFRDLARTVEDIQDSQSG
Protein: Protocadherin alpha 3 (Q91Y16)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MVFSQREDRHLLLWLLLFAAWEAGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPVATKNLFIYESRPLGSRFSLEGASDADIGTNSLLSYSLNSSEYFSLDVKRKDEEIKSLGLVLKKLLNREDIPEHNLLITAVDGGKPELTGTTQVKITVLDVNDNAPAFEKTFYKVRLPENAPNGTVVVDVDASDLDEGVNKDIVYSFHQDMSLEILSKFHLDPISGYITVKGNIDFEETKSFEIQIEAADKGTPPMTDHCTVLVEIVDVNDNVPELVIKSLSLPVLENSAPSTVIALISVSDRDSGANGQVTCSLTPQVPFKLVSTFKNYYSLVLDSVLDRETISNYNVVVTARDGGSPSLCTTASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLGPHAGSAVSELVSRTVGAGHVVTKVRAVDADSGYNAWLSYELQSAAGSGRLPFRVGLYTGEISTTRVLDETDAPRQRLLVLVKDHGEPVLTATATLLVSLVESGHTPNTPSRTLVDSAGREASLVDINVYLIIAICAVSSLLVLTLLLYLALRCSTAPTEGGPGKPMLVCSSAVGTWSYSQQRRQRVCSGEGPPKTDLMAFSPSLTPCPVNQDKEDKLVGDIDFSIKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1) (O75177)
Organism: Homo sapiens (Human)
Function: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). {ECO:0000250}.
Interaction partners:
- Zinc finger protein DPF3
- Zinc finger protein ubi-d4
- Zinc finger protein neuro-d4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- SWI/SNF complex subunit SMARCC2
- Actin-like protein 6B
- AT-rich interactive domain-containing protein 1A
- B-cell CLL/lymphoma 7 protein family member C
- Protein SSX1
Sequence:
MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILEYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQNMNLGPGALTQSGSSQGLHSQGSLSDAISTGLPPSSLLQGQIGNGPSHVSMQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGSQGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYSQQQAGYQQGAAQQQTYSQQQYPSQQSYPGQQQGYGSAQGAPSQYPGYQQGQGQQYGSYRAPQTAPSAQQQRPYGYEQGQYGNYQQ
Protein: Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) (Q8CGV2)
Organism: Mus musculus (Mouse)
Interaction partners:
- Aromatic-L-amino-acid decarboxylase
- Pterin-4-alpha-carbinolamine dehydratase
- Pterin-4-alpha-carbinolamine dehydratase 2
- Indoleamine 2,3-dioxygenase 2
- Indoleamine 2,3-dioxygenase 1
- Dihydropteridine reductase
- Sepiapterin reductase
- Tryptophan 2,3-dioxygenase
- Tryptophan 5-hydroxylase 1
- Dihydrofolate reductase
Sequence:
MQPAMMMFSSKYWARRGLSLDSAVPEDHQLLGSLTQNKAIKSEDKKSGKEPGKGDTTESSKTAVVFSLKNEVGGLVKALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPESIWTEEEDLEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNLPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKSFDPKTTCLQECLITTFQDAYFVSDSFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
Protein: Serine/threonine-protein kinase HAL4/SAT4 (EC 2.7.11.1) (Halotolerance protein 4) (P25333)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Promotes K(+) uptake, by the potassium transporter TRK1-TRK2, which leads to the subsequent cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+).
Interaction partners:
- Serine/threonine-protein kinase HAL5
- Low-affinity potassium transport protein
- High-affinity potassium transport protein
- Phosphopantothenoylcysteine decarboxylase subunit SIS2
- Serine/threonine-protein phosphatase PP-Z1
Sequence:
MTGMNDNNAAIPQQTPRKHALSSKVMQLFRSGSRSSRQGKASSNIQPPSNINTNVPSASKSAKFGLHTPTTATPRVVSNPSNTAGVSKPGMYMPEYYQSASPSHSSSSASLNNHIDINTSKSSSAASLTSSVSALSLSPTSAINISSKSLSPKFSHHSNSNTAITPAPTPTASNINNVNKITNTSAPICGRFLVHKDGTHEHHLKNAKRQEKLSTMIKNMVGASKLRGEAKSAVPDIIMDPKTTLKSNKNPPTLFAGFMKQVVDMDDKYPEGAPTSGALNCPERDIYRSDQKDSKNNTHNITTTKKDRQCFAEKYGRCQEVLGKGAFGVVRICQKKNVSSQDGNKSEKLYAVKEFKRRTSESAEKYSKRLTSEFCISSSLHHTNIVTTLDLFQDAKGEYCEVMEYCAGGDLFTLVVAAGKLEYMEADCFFKQLIRGVVYMHEMGVCHRDLKPENLLLTHDGVLKITDFGNSECFKMAWEKNIHLSGGVCGSSPYIAPEEYIKEEFDPRPVDIWACGVIYMAMRTGRQLWSSAEKDDPFYMNYLKGRKEKGGYEPIESLKRARCRNVIYSMLDPVPYRRINGKQILNSEWGREIKCCHNGRALK
Protein: NINAD (Q8I7X2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MCCSCCGVTQQKAWVFGLGTFFAVSGLLAIICWPGFIDSEIMKALPLTPTSKTFEKWEELPIPVYVYMYLWNWTNAADVQANGVKPIFAQLGPYVYREERKKMDLEWHDNGTVTFNPRRTWFWEEELSGGKQTDLITAPHLPSLAASNQMRNSNVFLKFMFNEALNANGGHLFVTHTAAEWLFESFYDEFLHYAMTLNNPLVPKIESDHFAWFLNRNGSKDFEGPFTVHTGVGDIKEMGEIKYWKGQNHTGWYDGECGRLNGSTTDLFVPDEPKEKALTIFIPDTCRIINLEFTGQSETIQGITGWKYEITPNTFDNGQINGNAKCWCPLERQPDNCPATGATDLGPCADGVPMYLSADHFMYADESYGSTISGYNPNYDQNNFYIIMERKMGVPLKVNANVMITLYIEPDSVIDILKGLPSFYAPLFTTASRAEIDEALASELRLALNLPAIGRYTGVGFLCLGCILIAVGILLTIKRKWYGQAELDKLALKDNEETPYEPEVPANVVERNF