wanglab/gogpt-training-data huggingface dataset:
Protein: Putative D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (P87228)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Interaction partners:
- Putative phosphoserine aminotransferase
- Uncharacterized kinase mug58
- Phosphoglycerate mutase
- Transcription elongation factor spt6
- Protein arg11
- Uncharacterized transcriptional regulatory protein C1683.13c
- Putative inorganic phosphate transporter C8E4.01c
- Probable phosphoserine phosphatase
- Uncharacterized transcriptional regulatory protein C27B12.11c
- Uncharacterized protein C22G7.07c
Sequence:
MDIKGGRRGNVEDSLNKLSLSPPDNNSSFLSNHFQVRKSYSQAPARTLKPFASEDIKILLLENVNQSALSNLKDEGYQVEFLKTSMSEDDLVEKIKGVHAIGIRSKTRLTRRVLEAADSLIVIGCFCIGTNQVDLDFAAERGIAVFNSPYANSRSVAELVIGYIISLARQVGDRSLELHRGEWNKVSSGCWEIRGKTLGIIGYGHIGSQLSVLAEAMGLHVVYYDILPIMPLGSAKQLSSLPELLHRADFVSLHVPASPETKNMISSKEFAAMKEGSYLINASRGTVVDIPALVDASKSGKIAGAAIDVYPSEPAGNGKDKFVDSLNSWTSELTHCKNIILTPHIGGSTEEAQYNIGIEVSEALTRYINEGNSIGAVNFPEVSLRSLTEADRNAARVLFVHRNVPGVLRQVNELFIDHNIKSQFSDSRGDIAYLVADISDCTPGSLEALHQKLESLPCKINTRLLY
Protein: Parathyroid hormone (PTH) (Q9Z0L6)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR001832}.
Interaction partners:
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Parathyroid hormone-related protein
- Parathyroid hormone 2 receptor
- Tuberoinfundibular peptide of 39 residues
- Fibroblast growth factor 23
- Osteocalcin-2
- Osteocalcin
- Osteocalcin-related protein
- 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
- Klotho
Sequence:
MMSANTVAKVMIIMLAVCLLTQTDGKPVRKRAVSEIQLMHNLGKHLASMERMQWLRRKLQDMHNFVSLGVQMAARDGSHQKPTKKEENVLVDGNPKSLGEGDKADVDVLVKSKSQ
Protein: Dickkopf-1 (Dickkopf-related protein 1b precursor) (Q9W6D9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MMHIAMLSTACLIFMGCIKVAGSTMLNSNAIKVGSGAAGSSHPVSPSPDVSPLDSLNFALDTPQQPLICESDEECGGEEFCFQSRGVCLQCKKRRKRCIRDAMCCPGNHCSNGVCIPNDPDIIQQLGMEEFVSIAHENSTALMPKVSTQGSPQNQMLKGLEGENCLRSSDCAETLCCARHFWSKICKPVLKEGQVCTKHKRKGTHGLEIFQRCDCGEGLSCRTQRGDGGKASRSLHTCQRH
Protein: Sphingoid long-chain base transporter RSB1 (A0A1D8PHN5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ifu5p
- Pleiotropic ABC efflux transporter of multiple drugs CDR1
- Sterol esterase
- Multidrug resistance protein CDR2
- Transcription factor TAC1
- SEC14 homolog 3
Sequence:
MNTMDLAVITEWTPTSTATSTTLSTIAATYAPALQSKISGAVHTLTSKGSTIANMDYISASRIIRGAQASLSIISAEHVLETATATDVQAQATQIIWQATENLLDLAWEENVYDIPRLNRTANILFLVLFAITFAIACLMWIKSRYWWFNVAWTCGTALEFLGYLGRVLSFSDMKKFDYYLLQLIALTLSPVFLMAGIYFLFGQLVVIHGRQYSWLKPLHYSYIFITCDVVSLVIQAVGGGMTAIAAQEYDDVDPGTYTMIAGIAFQVFSMSVFLLCWLVFCWNIYFRDISVNESKPSPYQKKSFMTFIKLLLNGDDANMYKLKVLDKYYNSSYKDLRRRPLYNYYAIAITLAVIAVYIRCIYRVVELAQGFSGYLITHEVYIMTLDAAMIGICCIIFILFHPQVVMGSSNVVGLRSIAKNKDQETGDKSYEEKTNNDIVSDNEESTLQGQNIVRGDPIQENKE
Protein: DNA repair protein RAD51 homolog 2 (AtRAD51B) (Q9SK02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein XRCC2 homolog
- DNA repair protein XRCC3 homolog
- DNA repair protein RAD51 homolog 3
- Crossover junction endonuclease MUS81
- Protein CHROMATIN REMODELING 25
- ATP-dependent DNA helicase Q-like 4A
- Meiotic nuclear division protein 1 homolog
- Meiotic recombination protein DMC1 homolog
- DNA repair protein RAD51 homolog 4
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A
Sequence:
MANKLIGEMGLHTKISNIFAARNIITAKDALSMTEFELMELLDVGMKEIRSAISFISEATSPPCQSARSLLEKKVENEHLSGHLPTHLKGLDDTLCGGIPFGVLTELVGPPGIGKSQFCMKLALSASFPVAYGGLDGRVIYIDVESKFSSRRVIEMGLESFPEVFHLKGMAQEMAGRILVLRPTSLANFTESIQELKNSILQNQVKLLVIDSMTALLSGENKPGAQRQPQLGWHISFLKSLAEFSRIPIVVTNQVRSQNRDETSQYSFQAKVKDEFKDNTKTYDSHLVAALGINWAHAVTIRLVLEAKSGQRIIKVAKSPMSPPLAFPFHITSAGISLLSDNGTELKGPGINTIHARGHSDMINFHGDCS
Protein: Sp1, isoform E (R9PY21)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLTDMTPTAGQLYGSQIPAMGMNISNIATHLQKPQVNPDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPNSPAAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASIYPYSRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGGSSGSVSGSVSGSGSHPGTPTSLHAHSANGTSSSLLGGGLHLATPHQMVAAGGSPVMLHQQQQQQQHQQQQQQQQQQQHQQQQQQQHQQQQQQHQQQQQQHHQQQQQHHHQQFGQQQHPHAHHLHHHAHHAHHLATGGSPGLDPSSLVDIKPPMV
Protein: Actin-binding protein (P15891)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:11950888, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15872087}. Note=Cortical actin patches.
Interaction partners:
- Actin
- Reduced viability upon starvation protein 167
- Adenylyl cyclase-associated protein
- Actin-regulating kinase 1
- Phosphatidate phosphatase APP1
- Proline-rich protein LAS17
- Actin cytoskeleton-regulatory complex protein SLA1
- Fimbrin
- Actin cytoskeleton-regulatory complex protein PAN1
- Actin-regulating kinase PRK1
Sequence:
MALEPIDYTTHSREIDAEYLKIVRGSDPDTTWLIISPNAKKEYEPESTGSSFHDFLQLFDETKVQYGLARVSPPGSDVEKIIIIGWCPDSAPLKTRASFAANFAAVANNLFKGYHVQVTARDEDDLDENELLMKISNAAGARYSIQTSSKQQGKASTPPVKKSFTPSKSPAPVSKKEPVKTPSPAPAAKISSRVNDNNDDDDWNEPELKERDFDQAPLKPNQSSYKPIGKIDLQKVIAEEKAKEDPRLVQKPTAAGSKIDPSSDIANLKNESKLKRDSEFNSFLGTTKPPSMTESSLKNDDDKVIKGFRNEKSPAQLWAERKAKQNSGNAETKAEAPKPEVPEDEPEGEPDVKDLKSKFEGLAASEKEEEEMENKFAPPPKKSEPTIISPKPFSKPQEPVKAEEAEQPKTDYKKIGNPLPGMHIEADNEEEPEENDDDWDDDEDEAAQPPLPSRNVASGAPVQKEEPEQEEIAPSLPSRNSIPAPKQEEAPEQAPEEEIEEEAEEAAPQLPSRSSAAPPPPPRRATPEKKPKENPWATAEYDYDAAEDNELTFVENDKIINIEFVDDDWWLGELEKDGSKGLFPSNYVSLGN
Protein: Voltage-gated potassium channel regulatory subunit KCNG3 (Potassium voltage-gated channel subfamily G member 3) (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3) (Q8R523)
Organism: Rattus norvegicus (Rat)
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8TAE7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TAE7}. Cytoplasm {ECO:0000250|UniProtKB:Q8TAE7}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Retains in the endoplasmic reticulum in the absence of KCNB1. {ECO:0000250|UniProtKB:Q8TAE7}.
Interaction partners:
- Ubiquitin-like protein FUBI
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Voltage-gated potassium channel subunit beta-1
Sequence:
MTFGRGGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTHTFHAAEELGREQPRPTGPEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRAAAADNRSLDDRSRYSASPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSAEFLN
Protein: Ferric reduction oxidase 3, mitochondrial (AtFRO3) (EC 1.16.1.7) (Ferric-chelate reductase 3) (F4I4K7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ferric chelate reductase involved in iron reduction in roots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transcription factor bHLH47
- Transcription factor bHLH101
- Metal transporter Nramp4
- Probable nicotianamine synthase 4
- Protein ZINC INDUCED FACILITATOR 1
- Oligopeptide transporter 3
- Transcription factor ORG3
- Fe
- Transcription factor bHLH100
- Probable plastid-lipid-associated protein 14, chloroplastic
Sequence:
MAARGRLVVARGNRSFSSIIRKYSLKRETNKKVIKNVIKLLTMVILMGTVVIWIMMPTSTYKKIWLKSMRAKLGKSIYFGKPGVNLLVYMFPMILLASLGSIYLHLKKQTRVNQFNSRMDRKKIDKFGALKRPMLVKAGLGIVTVTEVMFLMMFMALLLWSLANYFYHTFVTITPQSLPTDGDNLWQARLDSIAVRLGLTGNICLGFLFYPVARGSSLLAAVGLTSESSTKYHIWLGNLVMTLFTSHGLCYCIYWISTNQVSQMLEWDRTGISHLAGEIALVAGLLMWATTFPAIRRRFFEVFFYTHYLYMVFMLFFVFHVGISYALISFPGFYIFMVDRFLRFLQSRNNVKLVSARVLPCETVELNFSKNPMLMYSPTSILFVNIPSISKLQWHPFTITSSSKLEPKKLSVMIKSQGKWSSKLHHMLASSNQIDHLAVSVEGPYGPASTDYLRHDSLVMVSGGSGITPFISIIRDLLYVSSTNAYKTPKITLICAFKNSSDLSMLNLILPNSTEISSFIDIQIKAFVTREKVSTCNMNIIKTLSFKPYVSDQPISPILGPNSWLWLATILSSSFMIFIIIIAIISRYHIYPIDQSSKEYTSAYTSLIYLLAISISVVATSTVAMLCNKKSYFKGLYQNVDALSPLMIESSPDQLLPEFTNIHYGERPNLNKLLVGLKGSSVGVLVCGPRKMREEVAKICSFGSAANLQFESISFNW
Protein: Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) (Q15650)
Organism: Homo sapiens (Human)
Function: Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:26924529}. Cytoplasm, cytosol {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}.
Interaction partners:
- Activating signal cointegrator 1 complex subunit 3
- Activating signal cointegrator 1 complex subunit 2
- Mediator of RNA polymerase II transcription subunit 13
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 4
Sequence:
MAVAGAVSGEPLVHWCTQQLRKTFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEELITKWQKNDQELISDPLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTREGQDRLAVLLPGRHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCLFCGTLVCTHEEQDILQRDSNKSQKLLKKLMSGVENSGKVDISTKDLLPHQELRIKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKLERETLQKREEELRELRHASRLSKKVTIDFAGRKILEEENSLAEYHSRLDETIQAIANGTLNQPLTKLDRSSEEPLGVLVNPNMYQSPPQWVDHTGAASQKKAFRSSGFGLEFNSFQHQLRIQDQEFQEGFDGGWCLSVHQPWASLLVRGIKRVEGRSWYTPHRGRLWIAATAKKPSPQEVSELQATYRLLRGKDVEFPNDYPSGCLLGCVDLIDCLSQKQFKEQFPDISQESDSPFVFICKNPQEMVVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAV
Protein: Peptidase S58 DmpA (Q2U1W2)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
Sequence:
MRVQLSPEQVPRRMRIRELLPDLDLGAYPPGPLNSITDVPGVHVHTQEIFGAQGAINTGVTCIVPRPNWSTNACYAGVFRFNGSGELTGAHLIEETGLLCSPIVLTGTFNIGAAHQGIYQYAVKHLGTNKDGQLEWLMLPVVGETFDGYLHDCTSFAVAPAHIVHGLESVVAGEPVREGNVGGGVGMVCHGLKGGTGSSSRQVLGTYTVAALVQANYGQLRDLRIAGVPVGKILTEDAASDPSRQGMYEEVAQAKAEKDGSIIVVLATDAPLHPAQLQRVAKRATVGLARVGGQGHNLSGDIFLAFSTGNEIPVNQHKRPASVARTIDVLDDSALNTLFEATADAVEEAIYNALCMAESLQGFQGHTIEALPLARLKEIMRQYQRV
Protein: Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1) (Q9R097)
Organism: Mus musculus (Mouse)
Function: Inhibitor of HGF activator.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O43278}. Cytoplasm {ECO:0000250|UniProtKB:O43278}. Cell membrane {ECO:0000250|UniProtKB:O43278}.
Interaction partners:
- Hepatocyte growth factor activator serine protease
- Suppressor of tumorigenicity 14 protein homolog
- Hepatocyte growth factor
- Prostasin
- Serine protease hepsin
- Hepatocyte growth factor-like protein
Sequence:
MAGRRLARASISAVGVWLLCALGLQATEAELPSAPAELPGGAACLSRFTSGVPSFVLDTEASVSNGATFLGSPTARRGWDCVRSCCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPKEGFINYLTQELYRSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLNEADNTDWHLLQGDSDVRVERKRPEEVELWGLKEGTYLFQLTRTDSDQPEETANLTITVLTAKQTEDYCLASYKVGRCRGSFPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVQGISPKRHHPVCSGSCHATQFRCSNGCCIDGFLECDDTPDCPDGSDEATCEKYTSGFDELQNIHFLSDKGYCAELPDTGFCKENIPRWYYNPFSERCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREGSIPTVGSAEVAIAVFLVICIIVVLTILGYCFFKNQRKEFHSPLHHPPPTPASSTVSTTEDTEHLVYNHTTQPL
Protein: Homeobox protein ceh-30 (Q22909)
Organism: Caenorhabditis elegans
Function: Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:18056428}.
Interaction partners:
- Programmed cell death activator egl-1
- Transcription factor unc-37
- Protein male abnormal 3
- Sex-determining transformer protein 1
Sequence:
MSLLDPRQFLLPAFYLDPTTQALLAQAASTSPCNKISSSSSFRISDILEQSPNNSSHSNDHDPSPQSIKSDFSTSPRASSPGGDRMGSPGSCKKSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLTDTQVKTWYQNRRTKWKRQATSGMDLLSEPGNLSAVQNLIRSSPYWANYITALPMGTQLPMMGLPMSMIVPPAHAFQPSSSSNSPSTHISSESPQLDVSSNSE
Protein: Terpene synthase 9 (ShTPS9) ((1E,4E)-germacrene B synthase TPS9) (EC 4.2.3.71) (Alpha-humulene synthase TPS9) (EC 4.2.3.-) (Beta-myrcene synthase TPS9) (EC 4.2.3.15) (Germacrene A synthase TPS9) (EC 4.2.3.-) (Limonene synthase TPS9) (EC 4.2.3.-) (Terpinolene synthase TPS9) (EC 4.2.3.113) (G8H5M7)
Organism: Solanum habrochaites (Wild tomato) (Lycopersicon hirsutum)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (1E,4E)-germacrene B, but also smaller amounts of germacrene A and C, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into alpha-humulene, germacrene A and germacrene B. Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, limonene and terpinolene.
Interaction partners:
Sequence:
MAASSANKSRPLANFHPTVWGYHFLSYTHEITNQEKVEVDEYKETIRKMLVEAPEGSEQKLVLIDAMQRLGVAYHFHNEIETSIQNIFDAPKQNNNLHIVSLHFRLVRQQGHYMSSDVFKQFTNQDGKFKERLTNDVQGLLSLYEASYLRVRDEEILEEALAFTTTHLKSIVSNMSNNNNSLKVEVSEALTQPIRMTLPRMEARRYISIYENNDAHNHLLLKFAKLDFNMLQKLHQRELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVLKMTSIIDDTFDAYATFDELEPFNDAIQRWDANAIDSIQPYMRPAYQAFLDIYSEMEQVLSKEGKLDRVYYAKNEMKKLVRAYFKETQWLNDCDHIPKYEEHMENSLVSGGYMMIPTTCLVGMEEFISIETFEWLMNDPLIVRASSLIARAMNDIVGHEVEQERGHVASLIECYMKDYGASKQEAYAKFKKDVTNAWKDINKEFFRPTEVPMFVLERVLNLTRAADTLYKEKDAYTNAKGKLKNMINSILIESVKI
Protein: Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) (Q9JI91)
Organism: Mus musculus (Mouse)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:19932097}. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Interaction partners:
- Titin
- Myozenin-1
- Myozenin-2
- Alpha-actinin-3
- Telethonin
- Troponin T, cardiac muscle
- Myosin-7
- Myosin-6
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin light chain 3
Sequence:
MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGESDL
Protein: Protochlorophyllide reductase C, chloroplastic (PCR C) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase C) (POR C) (O48741)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide).
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:22212719}. Note=Prolamellar body of etiolated seedling.
Interaction partners:
- Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic
- Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic
- Chlorophyllide a oxygenase, chloroplastic
- Chlorophyll synthase, chloroplastic
- Chlorophyllase-1
- Chlorophyllase-2
- Protochlorophyllide reductase B, chloroplastic
- Magnesium dechelatase SGRL, chloroplastic
- Magnesium protoporphyrin IX methyltransferase, chloroplastic
- Magnesium dechelatase SGR1, chloroplastic
Sequence:
MALQAAYSLLPSTISIQKEGKFNASLKETTFTGSSFSNHLRAEKISTLLTIKEQRRQKPRFSTGIRAQTVTATPPANEASPEQKKTERKGTAVITGASSGLGLATAKALADTGKWHVIMACRNFLKAEKAARSVGMSKEDYTVMHLDLASLESVKQFVENFRRTEQPLDVLVCNAAVYQPTAKEPSFTAEGFEISVGTNHLGHFLLSRLLLDDLKKSDYPSKRMIIVGSITGNTNTLAGNVPPKANLGDLRGLASGLNGQNSSMIDGGEFDGAKAYKDSKVCNMLTMQELHRRYHEETGVTFASLYPGCIATTGLFREHIPLFRLLFPPFQKYITKGYVSEEEAGKRLAQVVSDPSLGKSGVYWSWNNNSSSFENQLSKEASDAEKAKKLWEVSEKLVGLA
Protein: Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (120 kDa G protein expressed in motor neurons) (Optic atrophy protein 1 homolog) (mG120) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] (O93248)
Organism: Oncorhynchus masou (Cherry salmon) (Masu salmon)
Function: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity).
Subcellular location: [Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O60313}; Single-pass membrane protein {ECO:0000255}. Note=Detected at contact sites between endoplasmic reticulum and mitochondrion membranes. {ECO:0000250|UniProtKB:O60313}.; SUBCELLULAR LOCATION: [Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:O60313}.
Interaction partners:
Sequence:
MLRVGRAVACVACNNLASKNMGVRFRMPLQKLHPLSRAIHHRYNASANAQRPPHCSAARHFTSMSRLPMRPPKPSPGGHGGWRYQQHRSFWMLRLASRLLKLRYIVLGSAVGGGYTAKKTYEEWKDMLPDMSAYNWVIPDFVWELSDQIDLDKLTKILPELEEIAKLLPELPDFDKIGENFTFLKSILFTAEAPGDTPVKAATEAPVTATPEASDKQFKKSSDKEKVDQLQEELLRTQMKYQRMLERLEKENKDLRKVVLQKDEKGIHQRKIKKSLIDMYSEVLDILSDFDSNYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVAMFKDSSREFDLGKEEDLAALRHEIELRMRKSVKEGQTVSPETISLSVKGPGIQRMVLVDLPGVISTVTAGMAADTKETIFSISKNYMQNPNAIILCIQDGSVDAEADRHRPGQSNGPAGERTIFVLTKVDLAEKNLASPNRIQQIVEGKLFPMKALGYFAVVTGKGSAGESIDSIKDYEEDFFQNSRLLRDGMLKAHQVTTKNLSLAVSDCFWKMVRESVEQQADAFKASRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEAILQKKLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPHKALEVAWETLQEEFARFMAEYKGKDQDDIFDKLKEAVKDESIKRHKWNERAMDSLRVIQHNALEDRSITDKPQWDAAIQFMEETLQARLKDTDSVINDMVGPDWKQRWMSWKNRSPEQHTRNETRNELERLLKLHEDHTAYLANDEVTTVRKNLEGRGVEVDPALIKDTWHQLYRRHFLQKALQHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLLITANTLRQQLTNTEVRRLEKNVKEVLEDFGEDNERKVHLITGRRVQLAEDLKKVREIQEKLEAFIEALHKEK
Protein: Protein GRAVITROPIC IN THE LIGHT 1 (F4KGE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for red (R) and far red (FR) light-induced and phytochrome-mediated deregulation of negative gravitropism leading to randomization of hypocotyl growth orientation.
Interaction partners:
- Structural maintenance of chromosomes protein 3
- Sister chromatid cohesion protein SCC2
- Sister chromatid cohesion 1 protein 4
- Sister chromatid cohesion 1 protein 1
- Sister chromatid cohesion 1 protein 3
- Sister chromatid cohesion 1 protein 2
- Condensin-1 complex subunit CAP-D2
- ARM repeat superfamily protein
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- E3 SUMO-protein ligase MMS21
Sequence:
MLPGILLCSLNPRNHSKKKKSERESLETEPKDIDYWYSVQFNRDPPRFALKSENNNHHSRSKSGGDFCKKKKRGEMANKVSNFSDLIQRVTASCLLHPLSAGRQDLAVNRREEYDTEEEENEEEGEIQYEDALEKENGKDETIRAKNGRNGVSVETVQEMEMVMDEVFTAAAAMKRAYVALQEAHSPWDPEKMHDADMAMVAELRRIGSLRERFRRMRGTGSGGRRKNDAGRGMLREAVAPYEAVVKELKKEVKVKDTEIENLKEKVKVASMANGNGGKKHRLLSSRKVNCTTQIAVSPVPELFEMTMIQVKEASKSFTGILLSLMRAAHWDIAAAVRSIEAASASSDGMSASSFASSVQSSVPNQHAKFALESYICRKIFQGFDHETFYMDGSLSSLINPDQYRRDCFAQFKDMKAMDPMELLGILPTCHFGKFCSKKYLSIIHQKMEESLFGDSEQRELVVAGNHPRSQFYGEFLGLAKAVWLLHLLAFSLDPSPSHFEANRGAEFHSQYMESVVRFSDGRVPAGQVVGFPVCPGFKLSHQGKGSIIKSRVYLVPRA
Protein: Histocompatibility 2, T region locus 13 (V9GXI3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAQRTLFLLLAAALTMIETRADPPKAHVTHHPRPAEPPPSTGSNMVNIAVLVVLGAVIIIEAMVAFVLKSSRKIAILPGPAGTKGSSAS