wanglab/gogpt-training-data huggingface dataset:
Protein: HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) (Q3TC93)
Organism: Mus musculus (Mouse)
Function: May be a modulator of IL-2 signaling.
Interaction partners:
Sequence:
MQSPAVLRTSRQVQNAHTGLDLSVPQHQEVRGKMMSGHVEYQILVVTRLAVFKSAKHRPEDVVQFLVSKKYSEIEEFYQKLYSCYPAASLPPLPRKVLFVGESDIRERRAMFDEILRCVSKDAQLAGSPELLEFLGTRAPGATGLATRDPSVLDDTASQPGDSDEAFDFFEQQDEVQPPTLGLSSKDVEKSLVGEEEEEEEEEEVLDPLGIMRSKKPKKRPEVAVRPKPAPRLTIFDEEVDPDAGLFSSDKKVSETRRPLETTQDSLKLFDDPDLGGAVSLGDPLLLPAASESRGPTSRPEHGDASKELFRVEEDLDLILNLGSEPKPKPQTKPKPLVPAKPALPRKPTLPASVGPSEPGSGPQKQQQIQAMDEMDILQYIRDHDTLAQDSPSLF
Protein: Photosystem I assembly protein Ycf4 (P0C514)
Organism: Oryza sativa subsp. indica (Rice)
Function: Seems to be required for the assembly of the photosystem I complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00437}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00437}.
Interaction partners:
- Cytochrome b559 subunit alpha
- Cytochrome b559 subunit beta
- Photosystem II CP43 reaction center protein
- Photosystem II D2 protein
- Photosystem II CP47 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II reaction center protein H
- Photosystem I P700 chlorophyll a apoprotein A1
- Photosystem I P700 chlorophyll a apoprotein A2
- Photosystem I iron-sulfur center
Sequence:
MNWRSEHIWIELLKGSRKRGNFFWACILFLGSLGFLAVGASSYLGKNIISVLPSQQILFFPQGVVMSFYGIAGLFISAYLWCTILWNVGSGYDRFDRKEGVVCIFRWGFPGIKRRVFLRFLMRDIQSIRIQVKEGLFPRRILYMEIRGQGAIPLTRTDEKFFTPREIEQKAAELAYFLRIPMEVF
Protein: Protein-arginine kinase activator protein (Q2G0P7)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Activates the phosphorylation activity of the protein-arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs.
Interaction partners:
- Protein-arginine kinase
- Transcriptional regulator CtsR
- ATP-dependent Clp protease ATP-binding subunit ClpC
- Low molecular weight protein-tyrosine-phosphatase PtpB
Sequence:
MLCENCQLNEAELKVKVTSKNKTEEKMVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFVVKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIVRRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAESEVQHDDA
Protein: Transcriptional coactivator hfi1 (O94301)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SAGA complex/transcription factor TFIID complex subunit Taf10
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex subunit Spt7
- SAGA complex/transcription factor TFIID complex subunit Taf6
- SAGA complex subunit Sgf73
- SAGA complex subunit Ngg1
- SAGA complex/transcription factor TFIID complex subunit Taf9
- SAGA complex subunit Spt3
- SAGA complex/transcription factor TFIID complex subunit Taf5
- Probable ubiquitin carboxyl-terminal hydrolase 8
Sequence:
MTEGVTVQKVQSASSNGHKPNTVISQIISEMQSLLGSSFEVYTKTMTDFLIGQLSRKEMKSMLLTFAGKSNFDKLHNSIIFHILKLMQKNNDTFSALHHLPWFKRKKVDNSLFLHKKISSQNAQVRLIKRIVMSLSYKDRARIKTALKEKPVTPSLISGLLLETRIAKLPKIPVSRDKLNSVFVNDIKAGYVAPLACETLELPDSESLKERITAISLENGLLGGVQKGVSDIILAGLESHLKNILSRCFSILNKNIRQKNTENDAAGFTINDLNLAWTIEPHAFVEQYPQKLRMPFLLHDSYTEDEISICAESPSYMLASNDAQSDRNSVASLLDEVLS
Protein: L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) (Q6ZMR3)
Organism: Homo sapiens (Human)
Function: Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme. Significantly increases the transcriptional activity of JUN, when overexpressed.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18351441}.
Interaction partners:
- Pyruvate kinase PKLR
- Pyruvate kinase PKM
- Putative aspartate aminotransferase, cytoplasmic 2
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Pyruvate carboxylase, mitochondrial
- NADP-dependent malic enzyme, mitochondrial
- NADP-dependent malic enzyme
- NAD-dependent malic enzyme, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Sequence:
MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKL
Protein: Auxin response factor 16 (Q93YR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin-responsive protein IAA31
- B3 domain-containing transcription factor ABI3
- Auxin-responsive protein IAA5
- Auxin-responsive protein IAA33
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin-responsive protein IAA17
- Auxin transporter protein 1
- Protein AUXIN SIGNALING F-BOX 2
- WUSCHEL-related homeobox 5
- Auxin-responsive protein IAA12
Sequence:
MINVMNPMKGGTEKGLDPQLWHACAGGMVRMPPMNSKVFYFPQGHAENAYDCVDFGNLPIPPMVLCRVLAIKYMADAESDEVFAKLRLIPLKDDEYVDHEYGDGEDSNGFESNSEKTPSFAKTLTQSDANNGGGFSVPRYCAETIFPRLDYNAEPPVQTILAKDVHGDVWKFRHIYRGTPRRHLLTTGWSNFVNQKKLVAGDSIVFMRAENGDLCVGIRRAKRGGIGNGPEYSAGWNPIGGSCGYSSLLREDESNSLRRSNCSLADRKGKVTAESVIEAATLAISGRPFEVVYYPRASTSEFCVKALDARAAMRIPWCSGMRFKMAFETEDSSRISWFMGTVSAVNVSDPIRWPNSPWRLLQVAWDEPDLLQNVKRVNPWLVELVSNVHPIPLTSFSPPRKKMRLPQHPDYNNLINSIPVPSFPSNPLIRSSPLSSVLDNVPVGLQGARHNAHQYYGLSSSDLHHYYLNRPPPPPPPSSLQLSPSLGLRNIDTKNEKGFCFLTMGTTPCNDTKSKKSHIVLFGKLILPEEQLSEKGSTDTANIEKTQISSGGSNQNGVAGREFSSSDEGSPCSKKVHDASGLETGHCKVFMESDDVGRTLDLSVLGSYEELSRKLSDMFGIKKSEMLSSVLYRDASGAIKYAGNEPFSEFLKTARRLTILTEQGSESVVV
Protein: 26S proteasome regulatory subunit, putative (RPN5) (B3H6B0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGDSGKLEATIDRLLNEEKQMRLAENVAGTRKAATEILQLCFDAKDWKLLNEQILNLSKKRGQLKQAVQSMVQQAMQYIDQTPDIETRIELIKTLNNVSAGKIYVEIERARLTKKLAKIKEEQGQIAEAADLMQEVAVETFGAMAKTEKIAFILEQVRLCLDRQDFVRAQILSRKINPRVFDADTKKDKKKPKEGDNMVEEAPADIPTLLELKRIYYELMIRYYSHNNEYIEICRSYKAIYDIPSVKETPEQWIPVLRKICWFLVLAPHDPMQSSLLNATLEDKNLSEIPDFKMLLKQVVTMEVIQWTSLWNKYKDEFEKEKSMIGGSLGDKAGEDLKLRIIEHVKYPRCLKVLRKDNLKETCRAFMPEHGGGGEASIGDGSVKSTDCKNRQTIWNCVLPDRKGQQRDSKLVGREFGEASRSCGKELPPNSQGNHGSQSRSQTLKTCGLLHENFSGSSSLSY
Protein: Enterotoxin type A (SEA) (P0A0L2)
Organism: Staphylococcus aureus
Function: Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, waves of cellular activation, cytokine production, and migration into the lung tissue and airways occur via alphabeta T-cells. Causes also the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death (Probable).
Subcellular location: Secreted.
Interaction partners:
Sequence:
MKKTAFTLLLFIALTLTTSPLVNGSEKSEEINEKDLRKKSELQGTALGNLKQIYYYNEKAKTENKESHDQFLQHTILFKGFFTDHSWYNDLLVDFDSKDIVDKYKGKKVDLYGAYYGYQCAGGTPNKTACMYGGVTLHDNNRLTEEKKVPINLWLDGKQNTVPLETVKTNKKNVTVQELDLQARRYLQEKYNLYNSDVFDGKVQRGLIVFHTSTEPSVNYDLFGAQGQYSNTLLRIYRDNKTINSENMHIDIYLYTS
Protein: NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (Q2F948)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYLLIVFLPLLGSSVAGFFGRFLGSEGTAIMTTTCVSFSSILSLIAFYEVALGASACYLRIAPWISSEMFDASWGFFFDSLTVVMLIVVTFISSLVHLYSISYMSEDPHSPRFMCYLSIFTFFMLMLVTGDNFLQLFLGWEGVGLASYLLIHFWFTRLQADKAAIKAMLVNRVGDFGLALGIFGCFTLFQTVDFSTIFACASAPRNEWIFCNMRLNAITLICILLFIGAVGKSAQIGLHTWLPDAMEGPTPVSALIHAATMVTAGVFMIARCSPLFEYSPTALIVITFAGAMTSFLAATTGILQNDLKRVIAYSTCSQLGYMIFACGISNYSVSVFHLMNHAFFKALLFLSAGSVIHAMSDEQDMRKMGGLASSFPLTYAMMLMGSLSLIGFPFLTGFYSKDVILELAYTKYTISGNFAFWLGSVSVLFTSYYSFRLLFLTFLVPTNSFGRDRLRCHDAPIPMAIPLILLALGSLFVGYLAKDMMIGLGTNFWANSPFVLPKNEILAESEFAAPTITKLIPILFSTSGASLAYNVNLVADQFQRAFQTSTFCNRLYSFFNKRWFFDQVLNDFLVRSFLRFGYSVSFEALDKGAIEILGPYGISYTFRRLAERISQLQSGSVYHYAFAMLLGSTPFVTFSRMWDSLSSWVDSRSSFILLVSSFLINKSSQE
Protein: Ankyrin repeat family A protein 2 (RFXANK-like protein 2) (Q9H9E1)
Organism: Homo sapiens (Human)
Function: May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q99PE2}. Membrane {ECO:0000250|UniProtKB:Q99PE2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99PE2}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 2
- Histone deacetylase 4
- Coiled-coil domain-containing protein 8
- DNA-binding protein RFX7
- DNA-binding protein RFX5
- Histone deacetylase 5
- Proline-rich protein 19
- Aryl hydrocarbon receptor repressor
Sequence:
MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE
Protein: Pentatricopeptide repeat-containing protein At1g31920 (Q9C6T2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g27290
- Tropinone reductase homolog At2g29290
- Kelch repeat-containing protein At3g27220
- Lon protease
- Calvin cycle protein CP12-2, chloroplastic
Sequence:
MIKAPILQSLLASRDDLTHNPEVNNFGGKEQECLYLLKRCHNIDEFKQVHARFIKLSLFYSSSFSASSVLAKCAHSGWENSMNYAASIFRGIDDPCTFDFNTMIRGYVNVMSFEEALCFYNEMMQRGNEPDNFTYPCLLKACTRLKSIREGKQIHGQVFKLGLEADVFVQNSLINMYGRCGEMELSSAVFEKLESKTAASWSSMVSARAGMGMWSECLLLFRGMCSETNLKAEESGMVSALLACANTGALNLGMSIHGFLLRNISELNIIVQTSLVDMYVKCGCLDKALHIFQKMEKRNNLTYSAMISGLALHGEGESALRMFSKMIKEGLEPDHVVYVSVLNACSHSGLVKEGRRVFAEMLKEGKVEPTAEHYGCLVDLLGRAGLLEEALETIQSIPIEKNDVIWRTFLSQCRVRQNIELGQIAAQELLKLSSHNPGDYLLISNLYSQGQMWDDVARTRTEIAIKGLKQTPGFSIVELKGKTHRFVSQDRSHPKCKEIYKMLHQMEWQLKFEGYSPDLTQILLNVDEEEKKERLKGHSQKVAIAFGLLYTPPGSIIKIARNLRMCSDCHTYTKKISMIYEREIVVRDRNRFHLFKGGTCSCKDYW
Protein: FHA domain-containing protein (Q582I8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMEGATQSSLSQIPVHDRVLLSGNMDSVDDDLETVIFSDGEDNLETCTVVTETDSDGDAGQHLRGATNGGAANRLHSQHTLGDYSDHTVQRTNNIPPTPAPAMAPVSASSLVTSIVPEPQLPVSFSSQAFPVILPVMQMTWELLAPVAAEEGVEREGEVGKQQSGGKFCVRYCLASKYGEPLRPTDINESALPERLTCACRMGRDDIPQPMKALRTNGRNQQTLLYKHTISREHCVVRFHFKLQCAPQGSAAAAPSGQKPFYKWTSFDVTDLSSSNGTYCRTVRLFPSHRYSFPLTRTNAAQCVELQLGTHYQCTIRVLGGNSIANCSRLVSSSDASSTAVAAVDASVQFSPSPEVVLTNFPPPKKVPRIYNGCSPFYVEDEYDNDNSNNNNNIDGVSSSLATKPGYTQQEPKEKLGCATVEESPMPRPVRQSCEEVSNTAPSTLPKQTTVEAEGTSGNAHRTSTNQTDSRRGTVTPSVEVLSSKVKEPKCSLTVVTTGIHCKQGVMQSLLHMNIYMNPDISNYKKVTHLVIKGPLVRSIKLLTVLPYVHHLVNVEWFEGILSCIPKDPMKRPPNLAAVLEKFNPSDFTYSEEPSADSIEVLNDFSLKALMDTPPEKRQALFEGLVFYLHPAAKPQSDADNNLRRVIVASGGTVTRRAALASVAILPEANMCGTGVAWEGVAKCRKEPLCIFVTTEDLFRSVLQQRRLTATTVQRPPGCTALPPSPQSRQKRKRS
Protein: Probable mediator of RNA polymerase II transcription subunit 15c (Q9SHV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- P300/CBP acetyltransferase-related protein-like protein
- Mediator of RNA polymerase II transcription subunit 15a-like protein
- ATP-dependent DNA helicase Q-like 3
- Histone acetyltransferase HAC12
- Histone acetyltransferase HAC5
- Uncharacterized protein At3g24150
- Histone acetyltransferase
Sequence:
MEGNTNWKPNEQGGNRDAANNRIDWRSQHEPELRQKVLSKIVEKFKEKFHAHEEYKINDIASKFEENFYSIATDKTTTSQQWLQQNTQSNLCVICFAKSGPYNRSRFSKTDTCSVTAAATSSAKFVETTYSTAFSSIKLTKHSITDQKSVFDTTEQKRQEQEQLINQLTNLPTSRPNNRDQQGAFQVSSSQQNNNVTLHAMSQQKNNLQSMTRGQQVGQSQPMMSQQYRQQYPMQQDPQNRNLQKHLDFVQNNTNQFQAASSLRQTQNITDQQNQPQQLERANPSILIMNIIVASQDSTGKTVNVNAGNWQEETYQKIKKLKEMCLPVLSLMHQRVAEKLRETESLPPQPMQAQWIEKLKAGKLSMEHLMFFLNVHRSSVSEKHRDKFSQYEYHILKFTKSQTMVLRPTQQQQGQFPPSQTAMQTQSPQVHVSQSLYKEQRRSRLMPSSQNEASSLLQIRPKLDPRDENIIMASSGNVMLPSVKQNPRAVNTNISSVQSLQKQKRFHHRQMQQQQPQQGNHQHQMQTNEMNDVRMRERVNIKARLLEQQVSSSQRQVPKQESNVSSSQIQNHSSPQLVDQHILPATINKTGTPLNSSGSAFVAPAPSPVPGDSEMPISVESPVSGVDEINSTLDSSSKLGTQETPLLFVPPPEPITERPIDRLIKAFQAASPKSLAESVSEISSVISMVDMIGGSFPSSGGSRAGLGEDLSERTRNFTTHEETNLSKRMKRSINIVPPDMSSQIDSYEQLSSLESEVVSTTSSGLKVNNIAPGYALLQEIKETNGRLVETVVEICDEDSLGTIVTCTYAPVALSATFKDHYKSGKIIFYVSKCLMQAQIQPLRLLFPMDYPYSSPIVLEEISFDTSVHKYEDLSARTRSRFSLSMKEFSEPGFSKGIAQTWNDCARATMVEYAERHGGGTFSSKYGAWETVLRAS
Protein: Calcium/calmodulin dependent protein kinase kinase 2 (F5H4I7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPS
Protein: Testis-specific expressed protein 55 (Testis-specific conserved, cAMP-dependent type II PK-anchoring protein) (A6X8Z9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000269|PubMed:19821082}.
Interaction partners:
- Serine protease 44
- Protein SPMIP9
- Inactive serine protease 54
- Disintegrin and metalloproteinase domain-containing protein 24
- Serine protease 55
- EF-hand calcium-binding domain-containing protein 10
Sequence:
MDEPPDESLNHENTTRAPDNEKNNIEGAGQALHRGSEHAGVGSSEPTGDKVSGQANAGSRQTGRRTSEEAEQRSSQPTEHRLPGHAERRASQQAERRLSERRTSQPPNQQLPSHSERKTSGKIDGQESLLSEQTDQETSEFDDLIPSASTDYLSARSQQQEYNQHGYWTEDSSDPHRLSEDLEKDYTRVKHITEKQAGYRSYYKTLAHIESRTLTDTNDYRETGQRLQPCTFEDSEAELPSKVSTTEETESATTIQAYNTQDTELTTSTSHEKLPSITTKVYYSSSPEKIQTTEYTSDTTPVFDQGRSSQRSSQSSRWRFPPIVFEDPYHVALRYVEKHNILHIFQQITENLVYERPDDPLYFMLDQVQNMIKHRDERQSD
Protein: FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (PPIase) (EC 5.2.1.8) (Metallochaperone SlyD) (Q9KNX6)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS3
Sequence:
MKIEKNTVASLAYQLTIEDGVVVDQSTVDAPLDYLHGHNNLITGLERELEGKVAGDKFTVTIAPEDAYGEHNEDLVQRVPADVFQGVDELEVGMRFLADTDQGPIPVEITEVDGDEVVVDGNHMLAGQSLTFTVEVVAVRAATEDEIAHGHIHQAGGCGHDHDHDHDHEGGCCGGEGHGHDHHGHGKKEGGCCGGGGCGSH
Protein: MEF2-activating motif and SAP domain-containing transcriptional regulator (MEF2-activating SAP transcriptional regulatory protein) (Q0ZCJ7)
Organism: Mus musculus (Mouse)
Function: Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16818234}.
Interaction partners:
Sequence:
MTLAASSQRSQIIRSKFRSVLQLRIHRRNQDCTSDSDPWISASGPALAPALPTVPASFLVSPGVLSPEPAYCPWRAPKKESPKNSQHWKEPKVRGNLTYHLYMPPEQRQGPRANLQVERSTLGPPDPPLWEKNSQRPHPRMKPSSAGVSSPSPPSHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKAMLLERMRGGTPPRERPKPRREDKEAAAPWPRLKPKALGTTRLPSTVKASATNRRLKFSGATDPLGAAPAPASVPAPTPSPALAPTPTPAPVPAPAPAPFPTPPASLTLEEELQEAIRRAQLLPNRNIDDILEDQVEPDDLLPPVPLDFPGSFDLLSPSPDSEGFSSVFSSSLPSPTSSLSPSPRALTDSLDWLEALSGGPPLGSGPPGPSIFSADLSDPSGSLLWELLPDPW
Protein: Eukaryotic translation initiation factor 3 subunit M (eIF3m) (PCI domain-containing protein 1) (Q99JX4)
Organism: Mus musculus (Mouse)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit H
Sequence:
MSVPAFIDISEEDQAAELRAYLKSKGAELSEENSEGGLHVDLAQIIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWKLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT
Protein: DNA-binding transcriptional repressor YiaJ (YiaKLMNOPQRS operon repressor) (YiaK-S operon repressor) (P37671)
Organism: Escherichia coli (strain K12)
Function: Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L-gulonate.
Interaction partners:
- 2,3-diketo-L-gulonate reductase
- L-xylulose/3-keto-L-gulonate kinase
- Putative L-ribulose-5-phosphate 3-epimerase SgbU
- Uncharacterized protein YjbD
- Uncharacterized HTH-type transcriptional regulator YhjC
- 3-keto-L-gulonate-6-phosphate decarboxylase SgbH
- 2,3-diketo-L-gulonate-binding periplasmic protein YiaO
- HTH-type transcriptional dual regulator CecR
- Protein YiaL
Sequence:
MGKEVMGKKENEMAQEKERPAGSQSLFRGLMLIEILSNYPNGCPLAHLSELAGLNKSTVHRLLQGLQSCGYVTTAPAAGSYRLTTKFIAVGQKALSSLNIIHIAAPHLEALNIATGETINFSSREDDHAILIYKLEPTTGMLRTRAYIGQHMPLYCSAMGKIYMAFGHPDYVKSYWESHQHEIQPLTRNTITELPAMFDELAHIRESGAAMDREENELGVSCIAVPVFDIHGRVPYAVSISLSTSRLKQVGEKNLLKPLRETAQAISNELGFTVRDDLGAIT
Protein: Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) (Q8R023)
Organism: Mus musculus (Mouse)
Function: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BSM1}.
Interaction partners:
- E3 ubiquitin-protein ligase RING2
- Lysine-specific demethylase 2B
- E3 ubiquitin-protein ligase RING1
- RING1 and YY1-binding protein
- S-phase kinase-associated protein 1
- YY1-associated factor 2
- Chromobox protein homolog 2
- BCL-6 corepressor
- Chromobox protein homolog 7
- Chromobox protein homolog 8
Sequence:
MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVSQPSGEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQYSVKEKRR
Protein: Photosystem I iron-sulfur center (EC 1.97.1.12) (9 kDa polypeptide) (PSI-C) (Photosystem I subunit VII) (PsaC) (P0C359)
Organism: Oryza sativa (Rice)
Function: Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01303}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01303}; Stromal side {ECO:0000255|HAMAP-Rule:MF_01303}.
Interaction partners:
Sequence:
MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLGPETTRSMALSY