Protein: Dynamin-2 (EC 3.6.5.5) (P39052)
Organism: Rattus norvegicus (Rat)
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21210813}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:9438853}. Cell projection, uropodium {ECO:0000250|UniProtKB:P50570}. Endosome {ECO:0000250|UniProtKB:P50570}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15048127}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P50570}. Recycling endosome {ECO:0000250|UniProtKB:P50570}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:P39054}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P39054}; Peripheral membrane protein {ECO:0000250|UniProtKB:P39054}. Cell projection, podosome {ECO:0000250|UniProtKB:P39054}. Cytoplasm {ECO:0000269|PubMed:21210813}. Cell junction {ECO:0000269|PubMed:21210813}. Postsynaptic density {ECO:0000269|PubMed:11583995}. Synapse, synaptosome {ECO:0000269|PubMed:11583995}. Midbody {ECO:0000269|PubMed:21195118, ECO:0000269|PubMed:9725914}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:19995918}. Note=Localized in recycling endosomes fragment to release nascent autophagosomes (By similarity). Co-localizes with PIK3C3 and RAB5A to the nascent phagosome. Localized at focal ahesion site upon induction of focal adhesions and stress-fiber formation, when interacts with SDC4 (By similarity). Exists as a dynamic component of the centrosome (PubMed:15048127). Associates with clathrin-coated vesicles at both the plasma membrane and the trans-Golgi network (TGN) (PubMed:9438853). {ECO:0000250|UniProtKB:P39054, ECO:0000250|UniProtKB:P50570, ECO:0000269|PubMed:15048127, ECO:0000269|PubMed:9438853}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:9725914}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:9725914}. Note=Sequestered to clathrin-coated pits and vesicles at the plasma membrane and the Golgi apparatus. {ECO:0000269|PubMed:9725914}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:9725914}. Note=Localized to numerous punctate spots on the plasma membrane. {ECO:0000269|PubMed:9725914}.
Interaction partners:
- Hematopoietic lineage cell-specific protein
- Activity-regulated cytoskeleton-associated protein
- Caveolin-1
- Src substrate cortactin
- Dynamin-3
- Myc box-dependent-interacting protein 1
- Amphiphysin
- Endophilin-A3
- Dynamin-1
- Endophilin-A1
Sequence:
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQNTSSHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPVGATSSFSAPPIPSRPGPQNVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPSRPTIIRPAEPSLLD