wanglab/gogpt-training-data huggingface dataset:
Protein: Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)] (P22466)
Organism: Homo sapiens (Human)
Function: Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Subcellular location: Secreted {ECO:0000269|PubMed:1370155, ECO:0000269|PubMed:1722333}.
Interaction partners:
- Galanin receptor type 1
- Galanin receptor type 2
- Galanin receptor type 3
- Pro-neuropeptide Y
- Somatostatin
- Protachykinin-1
- Galanin-like peptide
- VIP peptides
- Proenkephalin-B
- Pro-opiomelanocortin
Sequence:
MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGLTSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDIERS
Protein: Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression of viral proteins) (P04325)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)
Function: Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rev itself is translated from a fully spliced mRNA that readily exits the nucleus. Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1. KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus. In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs. Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface. Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex. Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export. Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import. The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
Subcellular location: Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04077}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04077}. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm. {ECO:0000255|HAMAP-Rule:MF_04077}.
Interaction partners:
Sequence:
MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE
Protein: Protein RNA-directed DNA methylation 3 (KOW domain-containing transcription factor 1) (Protein SPT5-like) (F4JW79)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Effector of RNA-directed DNA methylation (RdDM) triggered by small interfering RNAs (siRNAs, 24-nt RNAs). Functions as an adapter protein that binds scaffold transcripts generated by polymerase V and recruits AGO4 and AGO4-bound siRNAs to form an RdDM effector complex. Promotes the expression of 24-nt RNAs. Required for the initial establishment of DNA methylation. Together with AGO4, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19410546}. Note=Localized at punctate nuclear foci. Colocalizes with AGO4 and polymerase V in the nucleoplasm. {ECO:0000269|PubMed:19410546}.
Interaction partners:
- Protein argonaute 4
- Transcription elongation factor SPT4 homolog 2
- Transcription elongation factor SPT4 homolog 1
- DNA-directed RNA polymerases IV and V subunit 4
- FACT complex subunit SSRP1
- DNA-directed RNA polymerase II subunit 4
- Transcription elongation factor SPT6 homolog
- Protein INVOLVED IN DE NOVO 2
- DNA-directed RNA polymerase IV subunit 1
- DNA-directed RNA polymerases II, IV and V subunit 11
Sequence:
MDRKGKGKQVAGSDSYSGGQKRKNSVEFRDEGLRIKKRKNPEVLQFFEESAEVGYYGGSSDEDDDGLGFLNDMEDEPEVEESSKAGKGEKGKSSFVFPKEEDLNEEEFDRIMEERYKPGSGFLRYADDDIKDAIEMDALAPTSKDPPIWKVKCAIGRERRSVFCLMHKFVELRKIGTKLEIISVFSVDHVKGFIFIEADKEHDVLEACKSLVGIYATRMVLLPKAETPNLLTVQKKTKKVSEGTWARVKNGKYKGDLAQIVAVSDTRNKALIKLIPRIDIQALTQKYGGGVTVQKGQTPAPRLISSSELEEFRPLIQVRRDRDTGITFEHLDSLMLKDGYLYKKVSLDSISSWGVIPTKDELLKFTPVDRKETGDVEWISEIYGEERKKKILPTCREGGKGEGSGGGKGEGSGGGKGEGSRGGKGEGSSDFKSESSYELYNLVCFSRKDFGLIVGVDDKGDGYKVLKEGIDGPVVVTVGKKEMQNGPFDSKFTALDLNKKQISVNDVVKISKGPSEGKQGVVRQVYRGIIFLYDESEEENGGYFCCKSQSCEKVKLFTEESNEKTGGFDGTAFEDFVSSPKSPLSPEKEWQPRERYNSSNQGDIGSTYSIGQKLRIRVGPLKGYLCRVIALRYSDVTVKLDSQHKIFTVKSEHLAEVRDRNTVLSTSGDAGTGSFQPFGMLGTESSTGDWAIGAGTSSEGGNWNIGGPSTDSHESLNIERNMVQLCREKNPWGGSKPTSDVSPTVADDNTSAWANAAAENKPASASDQPGGWNPWGKTPASEAGTVSGWGDTSASNVEASSWEKQGASTSNVADLGSWGTHGGSSGGNKQDEDSVWGKLCEASESSQKKEESSWGKKGGSDGESSWGNKDGNSSASKKDGVSWGQQDKGSDESKGGSAWSNQCGDFGSGKKKDGSSGWNKSAEDSNANSKGVPDWGQPNDGSSWGKKGDGAASWGKKDDGGSWGKKDDGNKDDGGSSWGKKDDGQKDDGGSSWEKKFDGGSSWGKKDDGGSSWGKKDDGGSLWGKKDDGGSSWGKEDDGGSLWGKKDDGESSWGKKDDGESSWGKKDDGGSSWGKKDEGGYSEQTFDRGGRGFGGRRGGGRRGGRDQFGRGSSFGNSEDPAPWSKPSGGSSWGKQDGDGGGSSWGKENDAGGGSSWGKQDNGVGSSWGKQNDGSGGGSSWGKQNDAGGGSSWGKQDSGGDGSSWGKQDGGGDSGSAWGKQNNTSGGSSWGKQSDAGGGSSWGKQDGGGGGSSWGKQDGGGGSGSAWGKQNETSNGSSWGKQNDSGGGSSWGKQDGGGGGSSWGKQNDGGGGSSWGKQGDGGSKPWNEHSGGGRGFGERRGGGGFRGGRNQSGRGGRSFDGGRSSSWKTDNQENTWKSDQSGGSDWKKGWGEDSNNSKPSGSSAGGCAGNWPSWDTNSKKETNDKPGDDSKSAWGTSNDQVNTDNNNDSWNKKPNNDVGTSGEADNAWGGKTNAVAPSPSGSAAWGTGDKKTGW
Protein: Probable short-chain type dehydrogenase (P95150)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Uncharacterized oxidoreductase Rv0927c
- Probable conserved integral membrane protein
- Possible oxidoreductase
- Uncharacterized oxidoreductase Rv1714
Sequence:
MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVAIGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGFLDAVERQLGPIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYCASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVRVTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARARGEE
Protein: Voltage-dependent chloride channel 2, chloroplastic (AtVCCN2) (BESTROPHIN-like protein 2) (AtBest2) (O80832)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-dependent chloride (Cl) channel probably contributing to proton motive force (PMF) partitioning across the thylakoid membrane by anion influx into the lumen. Influences thylakoid ultrastructure, including lumen size and organization (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:26947269, ECO:0000269|PubMed:27216227}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Chloride channel protein CLC-e
Sequence:
MYQSMNLSFSSNFTNLSFLKPRLYSGISARAPKSLHFKFNPSCVSSGPKSDDSPLSEKLISLLKAVPNWSDGIKERRMQQKRSLYTHENWVRHRSSLRHLRHVSSSPSSRVILSLIPPVFFFTTVAILIAGYNSAVDLDWLPDFFPVLRASPLPYQLTAPALALLLVFRTEASYSRFEQGRKAWVKIISGTNDLARLVISSVHGSGDELIIRDALLRYIVAFPVALKCHVIYGSDIASDLKNVIEVDDLSLILQSKHRPRCVIQFISQSLQLLNLDSTKIDMLETKMMQLQEGIGVCEQLMGIPIPLSYTRLTSRFLVLWHLTLPVILWDDCHWNVVPATFISAASLFCIEEVGVLIEEPFSMLALDELCAMVLSNSDEAVESKEVIRNRIIAKKRILEIKHSSNGWHKS
Protein: Amnesiac neuropeptides [Cleaved into: Amnesiac peptide 24; Amnesiac peptide 30; Amnesiac peptide 56] (Q24049)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Adenylate cyclase 1
- 3',5'-cyclic-AMP phosphodiesterase, isoform I
Sequence:
MRSFCCCFYPAAVALHCVLLFYTFFLLFRASALRRRVVSGSKGSAALALCRQFEQLSASRRERAEECRTTQLRYHYHRNGAQSRSLCAAVLCCKRSYIPRPNFSCFSLVFPVGQRFAAARTRFGPTLVASWPLCNDSETKVLTKWPSCSLIGRRSVPRGQPKFSRENPRALSPSLLGEMR
Protein: Protein EXORDIUM-like 1 (PHOSPHATE-INDUCED 1) (Q9C6E4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in a brassinosteroid-dependent regulatory pathway that controls growth and development under low carbon and energy availability.
Subcellular location: Secreted. Secreted, extracellular space. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Cytochrome P450 71B17
- NDR1/HIN1-like protein 10
- Senescence-induced receptor-like serine/threonine-protein kinase
- AT3g16670/MGL6_12
- Transmembrane protein
- Probable glucan 1,3-alpha-glucosidase
Sequence:
MASFVMGYFLLFAVAFMCLDARTDKTQDYTSFQYHKGALLTGDVSINLIWYGKFKPSQRAIVTDFVASLSSSRRSTMAQNPSVATWWKTVEKYYQFRKMTTTRGLSLSLGEQILDQGYSMGKSLTEKNLKDLAAKGGQSYAVNVVLTSADVTVQGFCMNRCGSHGTGSGSGKKGSRFAYIWVGNSETQCPGQCAWPFHAPVYGPQSPPLVAPNNDVGLDGMVINLASLMAATATNPFGDGYYQGPKTAPLEAGSACTGVYGKGSYPGYAGELLVDATTGGSYNVKGLNGRKYLLPALFDPKTDSCSTLF
Protein: Arginine kinase 1 (EC 2.7.3.3) (P48610)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Arginase
- arginine kinase
- arginine kinase
- Nitric oxide synthase
- HDC05827
- Dual specificity protein phosphatase
- FI08446p
- LD30155p
- FI08238p
- Protein NipSnap
Sequence:
MVDAAVLAKLEEGYAKLAASDSKSLLKKYLTKEVFDNLKNKVTPTFKSTLLDVIQSGLENHDSGVGIYAPDAEAYTVFADLFDPIIEDYHGGFKKTDKHPASNFGDVSTFGNVDPTNEYVISTRVRCGRSMQGYPFNPCLTEAQYKEMESKVSSTLSGLEGELKGKFYPLTGMEKAVQQQLIDDHFLFKEGDRFLQAANACRFWPSGRGIYHNDAKTFLVWCNEEDHLRIISMQQGGDLGQIYKRLVTAVNEIEKRVPFSHDDRLGFLTFCPTNLGTTIRASVHIKVPKLASNKAKLEEVAAKYNLQVRGTRGEHTEAEGGVYDISNKRRMGLTEFEAVKEMYDGITELIKLEKSL
Protein: Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] (Q70SY1)
Organism: Homo sapiens (Human)
Function: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BH52}; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 3
- Cyclic AMP-responsive element-binding protein 3-like protein 1
- Cyclic AMP-responsive element-binding protein 3-like protein 3
- Cyclic AMP-responsive element-binding protein 1
- Cyclic AMP-dependent transcription factor ATF-6 beta
- Cyclic AMP-dependent transcription factor ATF-1
- Cyclic AMP-dependent transcription factor ATF-4
- Cyclic AMP-responsive element-binding protein 3-like protein 4
- Histone acetyltransferase p300
- Cyclic AMP-responsive element-binding protein 5
Sequence:
MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF
Protein: DIS3 like exosome 3'-5' exoribonuclease (E9PI20)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQTACQAVQHQRGRRQYNKLRNLLKDARHDCILFANEFQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPIVMVTEDEEAIQQYGSETEGVFVITFK
Protein: Cathepsin B-like protease 1 (EC 3.4.22.-) (Cathepsin B1) (AtCathB1) (F4HVZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol protease that plays a central role in plant programmed cell death (PCD). In addition to its role in protein degradation, may cleave and/or degrade a number of target proteins, activating signaling towards PCD. Contributes to the increase of caspase-3-like activity after UV-C-induced PCD and is required for abiotic stress-induced PCD. Functions redundantly with CATHB2 and CATHB3 in basal defense and distinct forms of plant programmed cell death (PCD). Participates in the establishment of basal resistance against the bacterial pathogen Pseudomonase syringae pv. tomato DC3000. Required for full levels of PCD during resistance (R) gene-mediated hypersensitive response (HR). Involved in the regulation of senescence, a developmental form of PCD in plants.
Interaction partners:
- Vacuolar-processing enzyme beta-isozyme
- Vacuolar-processing enzyme delta-isozyme
- Vacuolar-processing enzyme alpha-isozyme
- Vacuolar-processing enzyme gamma-isozyme
- UPF0235 protein At5g63440
- Eukaryotic aspartyl protease family protein
- Eukaryotic aspartyl protease family protein
- Proteasome subunit beta type-6
- Thiamine thiazole synthase, chloroplastic
- Cysteine proteinase inhibitor 6
Sequence:
MADSCCIRLHLLASVFLLLFSSFNLQGIAAENLSKQKLTSLILQNEIVKEVNENPNAGWKAAFNDRFANATVAEFKRLLGVIQTPKTAYLGVPIVRHDLSLKLPKEFDARTAWSHCTSIRRILVGYILNNVLLWSTITLWFWFLLGHCGSCWAFGAVESLSDRFCIKYNLNVSLSANDVIACCGLLCGFGCNGGFPMGAWLYFKYHGVVTQECDPYFDNTGCSHPGCEPTYPTPKCERKCVSRNQLWGESKHYGVGAYRINPDPQDIMAEVYKNGPVEVAFTVYEDFAHYKSGVYKYITGTKIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIRRGTNECGIEQSVVAGLPSEKNVFKGITTSDDLLVSSV
Protein: HAMP domain/sigma-54 interaction domain protein (Q72FR2)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- histidine kinase
Sequence:
MRFYRPPIIGSVFRTDRSAREWSIPKRMLLVGVPLLAAVLACFAFVTYKVGAHYLTTAYSRNSLTRAKAQAHEIASRLETARNELLFMADGILDPKRLARYLQGRTEAEGLRYREIAFQGNGGKDDAFVLLNTGRGVVSIPPDTALATRFGPFTRQSAPTDPQPGQVYLSQPLEVIYPSVPVPGGVQTLPLHVIRLSTPVFAEDGTMRGMLLLSLDVVALRNVLSLYASQRSPLHIYPQESERYRSFMFDPAGWILFQSESPDLPDADLSNDVVRSGLQGDLGRTGLDIAFRPGPENENYWAMVSEVQAGRAGLSTLGSRFADAASLNRSSFVSYVPIVFRGGPGQLPSVYAGLGFIDTSFMVMASSYKLAGALSVALGLGVFVITIVMVSMGVRIARPLIQLANAIENKAAEDDMSPMQDALLPREAHLLRKGVNMILARLREVVQASSLHDARSLAARKRQKVCFDTELAVSASDMPDPDSEKMPGIVGVSPAVKSLRALIRKAASIAADVLIIGETGTGKELTAEAIHANSSRAKGPFVSINCGALDENLLLDALFGHVKGAFSEAKGERKGAFLAADGGTLHLDEIGNASPKVQQALLRALSVRRIRPLGSDDEIGFDARIIAATNVDLLESAGQGAFREDLYYRLAVITIKTPPLRERREDIPALAGYFIKLASVETGRTLMGLSRGALDALLRYPWPGNVREIRNVITRAVAFAESDIIYEEDLRFGFSDAGAEASAEADPVAAEWPGVPGLSGMPGSVTVASAGGHQQGRAGTGAGQGGEAYPASGGATGMTDASMADVSPNGGGEGVGGFPVASFPADGGAFDDAARPRRRSSTMGRGYDAPPAGDDAGGAPPTREVVERSMQGDRARPGAALRDADVLASLNPRQQSVWPRILREGGITRSAYQQALGAEVSVRTAQYDLQDFMKRGVLAKVGRGPASRYVLMEDYRG
Protein: Cytochrome b6 (Q6ENE4)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00633}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00633}.
Interaction partners:
- Cytochrome b6-f complex subunit 4
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Cytochrome c oxidase subunit 3
- Cytochrome c domain-containing protein
- Cytochrome c domain-containing protein
- Cytochrome c domain-containing protein
- NAD
- Cytochrome b6-f complex subunit 5
- Cytochrome f
- Uncharacterized protein
Sequence:
MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFSSVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
Protein: Nuclear factor Y, subunit C13 (Q9FHS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA polymerase II subunit B4
- Nuclear transcription factor Y subunit B-1
- Nuclear transcription factor Y subunit C-5
- Nuclear transcription factor Y subunit C-8
- DNA polymerase II subunit B3-1
- Nuclear transcription factor Y subunit C-7
- Nuclear transcription factor Y subunit C-10
- Proliferating cell nuclear antigen 2
- Nuclear transcription factor Y subunit A-5
Sequence:
MEEEEGSIRPEFPIGRVKKIMKLDKDINKINSEALHVITYSTELFLHFLAEKSAVVTAEKKRKTVNLDHLRIAVKRHQPTSDFLLDSLPLPAQPVKHTKSVSDKKIPAPPIGTRRIDDFFSKGKAKTDSA
Protein: Sesquipedalian (Ses) (PH domain-containing endocytic trafficking adaptor) (A0A2R8YFI2)
Organism: Homo sapiens (Human)
Subcellular location: Early endosome {ECO:0000256|RuleBase:RU369082}. Recycling endosome {ECO:0000256|RuleBase:RU369082}. Golgi apparatus, trans-Golgi network {ECO:0000256|RuleBase:RU369082}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000256|RuleBase:RU369082}.
Interaction partners:
Sequence:
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEV
Protein: Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (P22133)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The isoenzyme MDH2 may function primarily in the glyoxylate cycle.
Subcellular location: Cytoplasm.
Interaction partners:
- Malate synthase 1
- Fumarate hydratase, mitochondrial
- Citrate synthase, peroxisomal
- Pyruvate carboxylase 2
- Citrate synthase, mitochondrial
- Phosphoenolpyruvate carboxykinase
- NAD-dependent malic enzyme, mitochondrial
- Citrate synthase 3, mitochondrial
- Pyruvate carboxylase 1
- Aspartate aminotransferase, mitochondrial
Sequence:
MPHSVTPSIEQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEFVASRSASS
Protein: Protein E6 (P26554)
Organism: Human papillomavirus 51
Function: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
Interaction partners:
Sequence:
MFEDKRERPRTLHELCEALNVSMHNIQVVCVYCKKELCRADVYNVAFTEIKIVYRDNNPYAVCKQCLLFYSKIREYRRYSRSVYGTTLEAITKKSLYDLSIRCHRCQRPLGPEEKQKLVDEKKRFHEIAGRWTGQCANCWQRTRQRNETQV
Protein: Mastermind-like protein 1 (Mam-1) (Q92585)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.
Interaction partners:
- Recombining binding protein suppressor of hairless
- Neurogenic locus notch homolog protein 1
- Histone acetyltransferase p300
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 4
- Recombining binding protein suppressor of hairless-like protein
- Mastermind-like protein 2
- Mastermind-like protein 3
- Histone acetyltransferase KAT2B
Sequence:
MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHGRPATHLHDTVKRNLDSATSPQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQSDKPSGADALQSSGKHSLGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTSGQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATPAPAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQGSPGSGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGPSNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAHIPRQTNVGQNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQHQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQAYPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRTSEEWMSDLDDLLGSQ
Protein: Non-canonical heme oxygenase HOZ, chloroplastic (EC 1.14.-.-) (Protein HOMOLOG OF HugZ) (Q8LDU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000255, ECO:0000269|PubMed:33284325}.
Interaction partners:
- AT4g27390/M4I22_200
- Membrane lipoprotein lipid attachment site-like protein, putative
- AT4g20040/F18F4_140
- AT4g27380/M4I22_190
- Nematode resistance protein-like HSPRO1
- At4g20000
- Protein transport protein SEC24 A
- Dynein light chain
- Myosin-4
- ATP-dependent zinc metalloprotease FTSH 9, chloroplastic
Sequence:
MKSLVAHFSTPLITARLVPRCIIHRASISAVSFSTVRRRFSPLTMASAAQSSSQAVSYGSGNSDTDVFKLIQAHEEKAARLSPVEEIRTVLNGSICGMLSTFSQKYEGYPSGSMVDFACDADGSPILAVSSLAVHTKDLLANPKCSLLIARDPEDRTGLRITLHGDAVLVSEKDQAAVRSAYLAKHPKAFWVDFGDFSFMRIEPKVVRYVSGVATAFLGSGEFSKEEYQAAKVDPIAQYAKPVTSHMNKDHEEDTKAIVHNITSIPVESALMLDLDSLGFNVKATLQGNTFKLRVPFPRRAQDRKDVKTLIVEMLQAAKSN