wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear factor of activated T-cells c3 isoform IB-deltaXa (Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_b) (B5B2S1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL
Protein: Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] (G3V918)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Multifunctional protein ADE2-like
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
- Adenylosuccinate lyase
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- Methylenetetrahydrofolate dehydrogenase
- Bifunctional purine biosynthesis protein ATIC
- Amidophosphoribosyltransferase
- C-1-tetrahydrofolate synthase, cytoplasmic
Sequence:
MAARVLVIGSGGREHTLAWKLAQSPHVKQVLVAPGNAGTASAGKISNAAVSINDHTALARFCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAALLESSKKFAKEFMDRHGVPTAQWRAFTSPEDACSFIMSADFPALVVKASGLAAGKGVIVAKSKAEACEAVQEIMQEKSFGAAGETVVVEELLEGEEVSCLCFTDGKTVAPMPPAQDHKRLLDGDRGPNTGGMGAYCPAPQVPKDLLVKIKNTILQRTVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTFDGLLSESPPVWLENHSAVTVVMASGGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDAKVVTSGGRVLTVTAVRENLMSALDEARKGLAALKFEGAVYRKDIGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVVAGIAAACRQAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERHQKLPQLERIAEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPRKLGVDLDAYTWRVPKVFSWLQQEGQLSEEEMARTFNCGVGAALVVSKDQTEQILHDIRQHQEDAWVIGSVVECPEDSPRVRVKNLIETMQTKGSVVTNGFLRSNFPSQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLVISNKAAVAGLDRAERAGIPTRVINHKLYKSRVEFDNAVDHVLEEFSVDIVCLAGFMRILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEAVPVQRDDTVATLSERVKAAEHKIFPAALQLVASGAVQLGEDGKIHWAREQ
Protein: Contig An01c0440, genomic contig (EC 1.10.3.2) (A2QB28)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MSISQSRLALLALCFVQWVSGRVVQFQLDLTYEDVSVAGDVHKAIVSNGQVPGPTLWLKQGDDVEFLVNNSMSISTTVHFHGIEQLGTPWSDGVPGLSQLQIQPGEQFLYKWKASQYGSYIYHSHTRAQIDDGLYGAIYIEPADSVERPFHLISGSDADEQQAMLAAEKNTRPVIISDWRAFSSHDILQIQNESGVEAYCANSVLINGKGSVICPSQEHINAVTTEQQKQILGNVTLTDMGCLPPTPGVVGPYPYDLSKVPKGFYEGCTPSEGPTEVFKVNVSSRYASFDLISMAGSTSLVFSIDEHPMYVYAVDGRYVEPLLVDAVTVPVAARYSVMVPLKSEDQAGDYTVRVANNYANQVINGTGVLSYDTATPKQIGSSQPYINEAGSNATATTVILNETDVVPFPVVAPAKKADRTYILNVENANSSYTWTLGNQYPMSNEELDPPVLFNLSSISQAYSAMTMNGTWVDLIINITTSGQPQHPIHKHSNKYFVIGTGNQPFIWSSVEEAMQEIPENFNFENPQMRDTFYSPSSATGPSWLAMRYHIVNPGPFLLHCHLQMHHVGGLALALLDGVDAWPTDIPEGYQLPVMPI
Protein: Contactin-associated protein 1 (Caspr) (Caspr1) (MHDNIV) (NCP1) (Neurexin IV) (Neurexin-4) (Paranodin) (O54991)
Organism: Mus musculus (Mouse)
Function: Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, paranodal septate junction {ECO:0000269|PubMed:25378149}.
Interaction partners:
- Neurofascin
- Contactin-1
- Contactin-2
- Protein 4.1
- Potassium voltage-gated channel subfamily A member 1
- Receptor-type tyrosine-protein phosphatase zeta
- Sodium channel protein type 8 subunit alpha
- Potassium voltage-gated channel subfamily A member 2
- Gliomedin
- Myelin basic protein
Sequence:
MMSLRLFSILLATVVSGAWGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSSILYFDGDDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGYAHHFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVMRHSRITFEGNVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRSNSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFCRWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLVYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYVPGYDTPGYVPGYHGPGYRLPEYPRPGRPVPGYRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDSHPGGKAPLPPSGPAQAPAPTPAPTQLPTPAPAPAPAPASGPGPRDQNLPQILEESRSE
Protein: Ribosome production factor 2 homolog (Ribosome biogenesis protein RPF2 homolog) (C8VMF9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU367086}.
Interaction partners:
- Ribosome biogenesis regulatory protein
- rRNA processing protein
- Nucleolar GTP-binding protein 1
- Ribosome assembly factor mrt4
- Ribosomal biogenesis protein Gar2
- Myosin-related protein homolog MlpA
- Ribosome assembly protein Noc2, putative
- Ribosome biogenesis protein erb1
- Nucleolar GTP-binding protein 2
- Ribosome biogenesis protein RLP24
Sequence:
MLREVKPKNPRTARILKAKEPQLIEGAKRVLLLHGSKCPTPLHTVLKVFHSLTTPHSVLFHKKNENIHPFESTESLEFLANKNDCGMVIFGSSNKKRPNCLTIARIFDSKVLDMAELLLLPDANGEGIPEMNRLSMHVAIGLRPLMLFSGSAWDDTTSTTHTMLKSMLVDLFKGETSDKIDVEGLQYALMVGAEEPTAGLAPIIHLRWYKIVTKRSGHKLPRVELEEIGPKLDFKVGRIQEAPRDVMKEAMKQGKKPNEEIKNKKNIGIDLIGDKVGRVHLAKQDLGGLQTRKMKGLKRRAGVESDDEGDADMMDVDEVSEDEKTKRARHD
Protein: Leucine-rich repeat-containing protein 3B (Leucine-rich repeat protein 15) (Q96PB8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNLVDLWLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDISTVV
Protein: SAC3 family protein 2 (Q9USI4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SAGA complex subunit Sus1
- PCI domain-containing protein C1105.07c
- Protein CSN12 homolog
- Cell division control protein 31
- 26S proteasome complex subunit rpn15
- mRNA export factor mex67
- Uncharacterized RNA-binding protein C106.12c
- Uncharacterized protein P25A2.03
- Nucleoporin nup124
- Nuclear import protein mog1
Sequence:
MSTKVKQKQKQKHRPKPSLDRSDSTKRAARAARFSTTLDANFQALKKKRKDEQESFQAKQSTNWEKSSVLVGTCRQMCPEFELEERKLQHAIHPYELDPVSKQAHPSLAVKAYHRPAAGKGPILPSDVRPPSILKNTIDYLFKVILDRYSLREAHAFVRDRTRAVRQDFSVQSSFSQDSVYCHELIARFHIISLHELAHTPNFSRQQEIEQLSKSMEILYTLGQLYDYMHLRKEHCTHEAEFRAYMVLLSLGDPSVGLDTLSWPDFVFKKPIVKTSLKLYSLAQRNNHTITTSNSISLSLVSSFNTEATSNLYTRFFKIASSFRVSYLMGCLLDLFVPSIRTGALKAMKKCYLSAHSNIPFKDLMKILAATSEDELVQCCKMHGLKIEYIGEQPSAVVLNRKTVITEPLLSSEISCRFADEKKPGTNVSDLICLDTDGSSLHRKKPKLFKKRSIVRQR
Protein: Lebercilin (Leber congenital amaurosis 5 protein homolog) (Q5U2Y9)
Organism: Rattus norvegicus (Rat)
Function: Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q86VQ0}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q86VQ0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17546029}. Note=Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium. {ECO:0000269|PubMed:17546029}.
Interaction partners:
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit 9
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 11
Sequence:
MGERDQSSDTDQERKGGKHPYSSHYSSDFGSSPQSSGPSSPVNTPPCASNREKNPKRHLSDHHVRHQTVRKVSPKAIPNKKGVRVGFRSQSLNREPLRKDPDIVTKRVLSARLLKITELQNEVSELQVKLAQLLKENKALKSLQYRQEKALSKFEDAENEISQLIHRHNGEITALKERLRKSQEKERMAEKRVKDTEGELFRTKFSLQKLKKISEARHLPERDDLAKKLVSAELKLDNTERKIKELSKNLELSTNSFQRQLLAERKRAFEAHDENKILQKELQRLHHKLKEKEKELDIKNIYANRLPKSSPKKEKEIARKHASCQSDFTDLCTKAVQTAEDFEPEEFPFTAQTVLCYENRWDGSEYLPSYLEYQERNEHGSESLSSTLEQEGKYSDDQDSCTAKQETGKSECEWEREELDKVKGKSSLLGRTEKLVLEAGSVQTESYQAQTIDKFQDEAERLKTEMLLAKLNEINKELQDPQSLSRPLLPLLPNFESKLYSPDRSLRPYTFSESLDRSFNGQHLSDMSFLTPRDEGQSPGLIRSPAPSDEFSFGSYVPSFGKTPGKSNPPSQKNSLLDFQSNMSEGLSKDSLDFISRKEKKATLMEQLFGTSASASATNTSASTTTNTTTNTNTNTNTNTNTNCNVPSKSIDSHFPAASRGDLDPLHFLSGDRSSRVREPDGEDEDLFLSEGRSFNPNRHRLKHTSTKPTVTAVDSIDEDIEEVTLR
Protein: Forkhead box protein B1 (Transcription factor FKH-5) (Q64732)
Organism: Mus musculus (Mouse)
Function: Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium. Essential for the mammillary nuclei maintenance. Negatively regulates the proliferation of oligodendrocyte progenitors and promotes oligodendrocyte maturation. Also expressed in mammary glands, plays a role in lactation, controls development of mammary glands and the inferior colliculi of the midbrain in the central nervous system that regulates the milk-ejection reflex.
Subcellular location: Nucleus {ECO:0000269|PubMed:27292133}.
Interaction partners:
Sequence:
MPRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKVLKSDHLAPSKPADAAQYLQQQAKLRLSALAASGTHLPQMPAAAYNLGGVAQPSGFKHPFAIENIIAREYKMPGGLAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVYGSAGMIDSATPISMTSGDYSAYGVPLKPLCHAAGQTLPAIPVPIKPTPAAVPALPALPAPIPTLLSNSPPSLSPTSSQTATSQSSPATPSETLTSPASALHSVAVH
Protein: Uncoordinated protein 79 (P42173)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein unc-80
- NCA Localization Factor
- Four domain-type voltage-gated ion channel alpha-1 subunit
- Voltage-dependent calcium channel type A subunit alpha-1
- Voltage-dependent L-type calcium channel subunit alpha
- Sodium leak channel NALCN
- Tetratricopeptide repeat protein 21 homolog
- WD Repeat protein
- Rx_N domain-containing protein
- PB1 domain-containing protein
Sequence:
MCLLFNRVVDMENPERHTVYLVVSLFVTFLSNKNSTPTDEKANAKKQSLVFRHFNTLLGYSSTEKCFTIPPARLRKAAVCNAFISGLPEILDMNLHTGNQLLPTVAQLLIHLPSPQKLASDQNVTNYSLALLTQHTRHLWLQSLILILYKYRFDQLPVSEYIVRLIGIVVKTLQNQVHECSDAADQSAEIDTWDEIEDDDVARAELIRPESLTVTTIQEATPAAEGMVHIGAVCVMQPTIVEPEGLAPEPLIARKRSTAVQEVRRKKSAIEVVKKSCTLRCGHCNEAIEMFDEETISLCLIALETFLHREPSMAAPILFKILYTVTRLIDTPMYPWHSTEMFVPANSRSVAKQMLRVSLHHLSTSAICLQLFDTKIPRPDAFWSVVALSLADFPELSPVYFIQILMEDLEESWPGSVKLIMKNLAFYIVEIPTDMYNNPWKDLVGHLETFFKRYHSAISADNGITPTRAEIENVIIVMTHVFKVQTFSSSKSPVTLVEAFARWLSESLHSADVSLESLLGVCTACNRALIRERDKQCITRALVTELMQAIKFKVKLHESNYVTIANMILQDAGEDIEVPLLDDQFNTAASEAIRPFLFEVLDFIADLHVIAKLKKESNSDALGGDLKVKLAEAIAVEMSRSNARDCRTVIRFIPWLMSPPSVTQAAPSAFADSVTNVRVLSWLLLGALHANHSCLPVPIECSQHMADYIHFVLAGFADQSKQSVVHMSALFHAFHLCQLWTVYCERAATYSSTTAFAHLVDFWARVTPAILQLLSHSKVLADMVNLHFLNTIQALQQVNSALLCQLYSMWAPILTAYHSQIPNQLRMKLDSCQNQPSLEAPLVTEWLKKVRYKISQVELQTSAASPYYTV
Protein: Chymotrypsin-like elastase family member 3B (EC 3.4.21.70) (Elastase IIIB) (Elastase-3B) (Protease E) (P08861)
Organism: Homo sapiens (Human)
Function: Efficient protease with alanine specificity but only little elastolytic activity.
Interaction partners:
- Carboxypeptidase A1
- Carboxypeptidase B
- Bile salt-activated lipase
- Chymotrypsin-like protease CTRL-1
- Carboxypeptidase A2
- Chymotrypsin-like elastase family member 2A
- Chymotrypsinogen B
- Chymotrypsin-like elastase family member 2B
- Pancreatic polypeptide prohormone
- Chymotrypsin-C
Sequence:
MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
Protein: cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) (P63248)
Organism: Mus musculus (Mouse)
Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Exportin-1
- cAMP-dependent protein kinase inhibitor gamma
Sequence:
MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEDDGQRSSTEQSGEAQGEAAKSES
Protein: Glycolate oxidase iron-sulfur subunit (EC 1.1.99.14) (Glycolate dehydrogenase subunit GlcF) (Glycolate oxidase subunit GlcF) (P52074)
Organism: Escherichia coli (strain K12)
Function: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:2689218, ECO:0000305|PubMed:8606183}. Note=Glycolate oxidoreductase activity was shown to be firmly associated with the cytoplasmic membranes (PubMed:2689218). And the GlcF subunit itself could only be detected in the membrane fraction (PubMed:8606183). {ECO:0000269|PubMed:2689218, ECO:0000269|PubMed:8606183}.
Interaction partners:
- Glycolate oxidase subunit GlcD
- Glycolate oxidase subunit GlcE
- Protein GlcG
- Malate synthase G
- Glyoxylate carboligase
- Malate synthase A
- Isocitrate lyase
- Glyoxylate/hydroxypyruvate reductase B
- Lactaldehyde dehydrogenase
- Phosphoglycolate phosphatase
Sequence:
MQTQLTEEMRQNARALEADSILRACVHCGFCTATCPTYQLLGDELDGPRGRIYLIKQVLEGNEVTLKTQEHLDRCLTCRNCETTCPSGVRYHNLLDIGRDIVEQKVKRPLPERILREGLRQVVPRPAVFRALTQVGLVLRPFLPEQVRAKLPAETVKAKPRPPLRHKRRVLMLEGCAQPTLSPNTNAATARVLDRLGISVMPANEAGCCGAVDYHLNAQEKGLARARNNIDAWWPAIEAGAEAILQTASGCGAFVKEYGQMLKNDALYADKARQVSELAVDLVELLREEPLEKLAIRGDKKLAFHCPCTLQHAQKLNGEVEKVLLRLGFTLTDVPDSHLCCGSAGTYALTHPDLARQLRDNKMNALESGKPEMIVTANIGCQTHLASAGRTSVRHWIEIVEQALEKE
Protein: Semaphorin-6D (Q8NFY4)
Organism: Homo sapiens (Human)
Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm.
Interaction partners:
- Plexin-A1
- Plexin-A4
- Triggering receptor expressed on myeloid cells 2
- Plexin-A2
- Neuronal cell adhesion molecule
- TYRO protein tyrosine kinase-binding protein
- Spatacsin
- Plexin-A3
- Maspardin
Sequence:
MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (C9JYN7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTYE
Protein: Testis tissue sperm-binding protein Li 93mP (A0A140VK60)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGVKYPGQDPVDLDIYQSSHMVDYQPYRKHKYSRVTPQEQAKLDAQLRDKEFYRPIPNPNPKLTDGYPAFKRPHMTAKDLGLPGFFPSQEHEATREDERKFTSTCHFTYPASHDLHLAQGDPNQVLQSADFPCLVDPKHQPAAEMAKGYLLLPGCPCLHCHIVKVPILNRWGPLMPFYQ
Protein: Tryprostatin B synthase ftmPT1 (EC 2.5.1.106) (Brevianamide F prenyltransferase ftmPT1) (Fumitremorgin biosynthesis protein B) (Tryptophan aminopeptidase ftmPT1) (EC 3.4.11.17) (Q4WAW7)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Brevianamide F prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities. The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA. Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B. FtmPT1/ftmB shows also tryptophan aminopeptidase activity with preference for linear peptides containing a tryptophanyl moiety at the N-terminus. The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively. The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B. Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties. In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
Interaction partners:
- Tryprostatin B 6-hydroxylase
- Nonribosomal peptide synthetase 13
Sequence:
MPPAPPDQKPCHQLQPAPYRALSESILFGSVDEERWWHSTAPILSRLLISSNYDVDVQYKYLSLYRHLVLPALGPYPQRDPETGIIATQWRSGMVLTGLPIEFSNNVARALIRIGVDPVTADSGTAQDPFNTTRPKVYLETAARLLPGVDLTRFYEFETELVITKAEEAVLQANPDLFRSPWKSQILTAMDLQKSGTVLVKAYFYPQPKSAVTGRSTEDLLVNAIRKVDREGRFETQLANLQRYIERRRRGLHVPGVTADKPPATAADKAFDACSFFPHFLSTDLVEPGKSRVKFYASERHVNLQMVEDIWTFGGLRRDPDALRGLELLRHFWADIQMREGYYTMPRGFCELGKSSAGFEAPMMFHFHLDGSQSPFPDPQMYVCVFGMNSRKLVEGLTTFYRRVGWEEMASHYQGNFLANYPDEDFEKAAHLCAYVSFAYKNGGAYVTLYNHSFNPVGDVSFPN
Protein: Pollux protein (Q9TY11)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMRNAQHDTSANPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPSAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYNVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTPLSPPSTASNSSGGSIFSRMGYRTTPPALSPLAQRQSYGVAITTAPCPHHMEEVAPATTMAVMPQEDVEEPQPMHPLSMVGGDVNVRFKGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAVRVAPVPVELAPPAATATTGRS
Protein: Leukemia associated gene protein (Q9EPX7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
Interaction partners:
Sequence:
MDNQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVIFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMLIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRCKLLMAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKNKPSHGSKDANKESGKASKPHKVAREHRERPRKDSESRSCSKEPEREPKSAKDAARKLPKEEKAPVPKAAFKEPKMALKETKLESLSPKGVPQPPTLPKASSKRPAATDSPKLSAKKPKKSGSKGTRRAPGTSPRASSFPDKKVARDKNSKGDKGKAESEPREAKRTLQTEDSNSEDEASFRSESAQSSPANASSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEGSDEDDSSSGEENTRKANPGRESRLSFSDSESDNSADSCLPGREPLPPQKPLPPSSKVSGRRSPEPCSKPEKMLKKATYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDESTVRKLQSCLEAVAT