wanglab/gogpt-training-data huggingface dataset:
Protein: Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5) (A0A1S6M251)
Organism: Sus scrofa (Pig)
Function: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Golgi apparatus {ECO:0000269|PubMed:29546034}. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Solute carrier family 35 member A2
Sequence:
MRVRRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMMQAQGILIRDNMRTIGAQVYEQVVRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDTIHELFSKDPAIKLGGHWKPSDCVPRWKVAILIPFRNRHEHLPVLLRHLIPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLVFHDVDHIPENDRNYYGCGQMPRHFATKLDKYMYLLPYNEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPYHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYFANITYDALYKNITVNLTPELAQVTEY
Protein: Large ribosomal subunit protein uL1c (Q8RWT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein eL42z/eL42y
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Large ribosomal subunit protein uL24c
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL31c
- Large ribosomal subunit protein uL5c
- Large ribosomal subunit protein bL28c
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL21m
Sequence:
MAAMKLLLSQARRQGLIKPFSSPFQQIPRLFSSSSSSSSSSSSSSDSNPSPDSNESRKKAVTIEPVSYAAKPKDQKSEPKNVESTENLQSPESANWTREEIRYVKDSPSINPVSYAQRVAPLPEDRVAGENEGDRTPEEMERERKRIELENRARRRFLRANAVEEDTSSLPLPTLLKPELKHGKKPIFDLMEAIREIKGNAKAKFDETLEAHVRLGIEKGRSELIVRGTLALPHSVKKDVKVAFFAEGADAEDAKAAGADVVGGLELIEEILKSGKIDFDRCLATPKMMPRVYKISRILNNHGLMPNPKQGSVTKDVTKAVKDAKAGHTKFRMDKTSILHVPLGKMSFSEEALRENVGAFMNALLLAKPAGLKKTSKYAGYVNAFHLCSTMGKGYPVSIQSLSRAADLHTKLQLK
Protein: LP05501p (Q8SZW9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTGGGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSNNKDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTITSSGSSSNSSSKKRKADSAKSTSSISTSGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSNATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSENLRLEEHVTSLIARRDHLLAVNARLQIPLSTIASNTKAEAHGK
Protein: Soluble inorganic pyrophosphatase 1 (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase 1) (PPase 1) (Q93V56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the irreversible hydrolysis of pyrophosphate (PPi) to phosphate. The MgPPi(2-) complex binds to the enzyme only after a free Mg(2+) ion has bound (Ref.9). No activity with glycerol-3-phosphate, glucose-6-phosphate, p-nitrophenylphosphate, ADP, NADP(+), NAD(+),NADH, NADPH or phosphoribosyl pyrophosphate as substrates (Ref.9). Controls the equilibrium of gluconeogenic reactions in the heterotrophic growth phase of early seedling establishment. Determinates the rate of cytosolic glycolysis, providing carbon for seed storage lipid accumulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15610358}.
Interaction partners:
- ATP synthase subunit b, chloroplastic
- Pyrophosphate-energized vacuolar membrane proton pump 1
- Putative ATPase, plasma membrane-like
- ATPase 5, plasma membrane-type
- ATPase 9, plasma membrane-type
- ATPase 8, plasma membrane-type
- ATPase 6, plasma membrane-type
- ATPase 11, plasma membrane-type
- ATP synthase subunit delta, chloroplastic
- V-type proton ATPase subunit c''1
Sequence:
MSEETKDNQRLQRPAPRLNERILSSLSRRSVAAHPWHDLEIGPGAPQIFNVVVEITKGSKVKYELDKKTGLIKVDRILYSSVVYPHNYGFVPRTLCEDNDPIDVLVIMQEPVLPGCFLRARAIGLMPMIDQGEKDDKIIAVCVDDPEYKHYTDIKELPPHRLSEIRRFFEDYKKNENKEVAVNDFLPSESAVEAIQYSMDLYAEYILHTLRR
Protein: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) (Uridine 5'-monophosphate synthase) (UMP synthase) (P14965)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Phosphoribosylaminoimidazole carboxylase
- Dihydroorotate dehydrogenase
- 3-isopropylmalate dehydrogenase
- Orotate phosphoribosyltransferase
- Uridylate kinase
- Uracil phosphoribosyltransferase 1
- Protein transport protein got1
- Histidinol-phosphate aminotransferase
- Uridine kinase
- Uracil phosphoribosyltransferase 2
Sequence:
MDARVFQSYSARAEGMKNPIAKELLALMEEKQSNLSVAVDLTKKSEILELVDKIGPYVCVIKTHIDVVEDFDQDMVEKLVALGKKHRFLIFEDRKFADIGNTVKLQYASGVYKIASWAHITNCHTVPGEGIIQGLKEVGLPLGRGLLLLAEMSSKGSLATGSYTEKTLEWFEKHTDFCFGFIAGRRFPNLQSDYITMSPGIGLDVKGDGLGQQYRTPEEVIVNCGSDIIIVGRGVYGAGRNPVVEAKRYREAGWKAYQQRLSQH
Protein: Olfactory receptor 10A6 (Olfactory receptor OR11-96) (Q8NH74)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MERQNQSCVVEFILLGFSNYPELQGQLFVAFLVIYLVTLIGNAIIIVIVSLDQSLHVPMYLFLLNLSVVDLSFSAVIMPEMLVVLSTEKTTISFGGCFAQMYFILLFGGAECFLLGAMAYDRFAAICHPLNYQMIMNKGVFMKLIIFSWALGFMLGTVQTSWVSSFPFCGLNEINHISCETPAVLELACADTFLFEIYAFTGTFLIILVPFLLILLSYIRVLFAILKMPSTTGRQKAFSTCAAHLTSVTLFYGTASMTYLQPKSGYSPETKKVMSLSYSLLTPLLNLLIYSLRNSEMKRALMKLWRRRVVLHTI
Protein: Period 1-like protein (Q6E2N4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDDNSDSAPSNDADSGAGGIEKKAGRSCGMSESSPSSNPESSGSGGLSGPKGSAGGNRGVNSDDTDGLSSGNDSGERESEGGMQRGSGSRGRQSNRSYQSSSSQNGKDSAMGMETTESNKSSNSHSPSPPSSSLAYSLLSASSEQDPPSTSGCSSDQSARVQTQKELMRALNELKIRLPPERKMKGRSSTLNALKYALSCVRQVRANQEYYHQWNVEECHGCSLDLSTFTVEELDNITSEYTLKNTDTFTMAVSFLSGKVVYISPQGSSLLRSKPERLHGVLFSELLAPQDVSTFYSNTAPCKLPAWASCIGSVSPPMECTQEKSMFCRISGDVSSSSDVRYYPFRLTPYLLTLRDSDMAFPQPCCLLIAERVHSGYEAPRIPLDKRIFTTSHTPSCVFQEVDERAVPLLGYLPQDLVGTPVLLCIHPDDRHIMVAIHKKILQFAGQPFEHSPLRMCARNGEYMTIDTSWSSFINPWSRKVAFIVGRHKVRTSPLNEDVFTPPRGLEERALTPDIVQLSEQIHRLLVQPVHCGSSQGYGSLPSNGSHEHQPSAASSSDSSGPGLEDPSQLHKPMTFQQICKDVHMVKTNGQQVFIDSRNRPPPKKHSTAGALKAGQSAEVCRSLVPCAAPPSKSSAPSLIVQKEPPTTFSYQQINCLDSIIRYLESCNVPNTVKRKCGSSSCTASSTSDDDKQQEAPGNAKGPSVSLVDDSALLPPLALHNKAESVASVTSQCSFSSTIVHVGDKKPPESDIVMEEAPPTPNTALPVTQPQFPPMATPSLPLSPAPDRDAGRRGGPGASAGGERLGLTKEVLSAHTQQEEQNFMCRFGDLSKLRVFDPTSAVRRRPNAPLSRGVRCSRDYPAAGSSGRRRGRGGKRLKHQESSEQTGSCSPAGPIRGLLPGVPALGRPSNPSIPMGPTASSSSWPTSGSQASVPNVQYPPTVLPLYPVYPPISHPVSDPSMQSGLRFPLQNSQMAPPMVPPMMALVLPNYMFPQPSVGMAQPFYSPNSAFPFAAANMGSPAPCQIQTPIQRAHSRSSTPHSYSQRENGAEREGAESPLFQSRCSSPLNLLQLEESPSNRFEVASGQQTTSPMVGQGGGAGGQASSNQRGSAVDSKTNENGETNESNQDAMSTSSDLLDLLLQEDSRSGTGSAASGSGSSGTGSSGSGSGSSGSGSNGCSSSGSGTRSSQSSNTSKYFGSVDSSENSHSRKQTAEGDGEAQFIKCVLQDPIWLLMANTDEKTMMTYQLPIRDRDSVLKEDRAALRAMQKHQPRFTEEQKSELSQVHPWIRTGRLPRAINISACAGCRSPPSVPSATPFDVEIHEMEFCSVLAVAEEKQTPTDTVMEKSETDGQNETCKENNGTVTTAQINDQEMLTEEQEMTSQIEEEMGASHTQMTH
Protein: Protein stunted (Q9VXN2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Activates the G-protein coupled receptor mth in vitro, leading to increased intracellular calcium ion levels.
Interaction partners:
- ATP synthase subunit O, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase subunit b, mitochondrial
- ATP synthase subunit g
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit beta, mitochondrial
- ATP synthase-coupling factor 6, mitochondrial
- ATP synthase subunit alpha, mitochondrial
- Putative ATP synthase subunit f
Sequence:
MTAWRAAGITYIQYSNIAARILRESLKTGLRADAAKRDASHVKFTPWANGKPAQRQTQSES
Protein: POU domain protein CF1A (Chorion factor 1A) (CF1-A) (Protein drifter) (Ventral veins lacking protein) (P16241)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
Subcellular location: Nucleus.
Interaction partners:
- SOX domain-containing protein dichaete
- FMRFamide receptor
- Inhibitory POU protein
- Aryl hydrocarbon receptor nuclear translocator homolog
Sequence:
MAATSYMTPPSGDLDMALGGGGYHTSSPRSAADAGEMKYMQHHHHHHAAAAAAAHHQLPSSPSPNGQGNGGGLGLGSGSGLGSWSALHPDPWMQTHHTHHLPAAAAVASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPHAGHYAPTGGSPLQYHHAMNGMLHHPAHAVAAAHHQSVAPLHHTLRGESPQLHIHHHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGDMMDGMPPGHMHHGGYHPHHDMHGSPMGTHSHSHSPPMLSPQNMQSSAVAAHQLAAH
Protein: Vacuolar protein sorting-associated protein 53 (P47061)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Interaction partners:
- Vacuolar protein sorting-associated protein 54
- Vacuolar protein sorting-associated protein 52
- Vacuolar protein sorting-associated protein 51
- GTP-binding protein YPT6
- t-SNARE affecting a late Golgi compartment protein 2
- Conserved oligomeric Golgi complex subunit 4
- t-SNARE affecting a late Golgi compartment protein 1
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 3
Sequence:
MLEGTVDYDPLEDITNILFSKESLNNIDELISITRSYKKQLQEDILKEENELKEHPKNSAEIEASLRKVFQDFKETQDVSASTELTISNLTEGISYLDIAKKNLTHSLTLFQNLKILTDSYIQCNELLSQGSFKKMVSPYKIMCSLAENTFISYKSLDEINYLLSSISRLKGDTLSKIKQNYNALFSGGNISEHDTALTMELREGACELLDCDTSTRAQMIDWCLDKLLFEMKEIFRVDDEAGSLENLSRRYIYFKKILNNFNSKFADYFLKDWEMAVRLTTTFYHITHKDLQTLLKREFKDKNPSIDLFMTALQSTLDFEKYIDVRFSKKIKEPKLSSCFEPYLTLWVSHQNQMMEKKFLSYMSEPKYPSNETESLVLPSSADLFRTYRSVLTQTLELIDNNANDSILTSLANFFSRWLQTYSQKILLPLLLPDNIEVQDKLEAAKYTVLLINTADYCATTIDQLEDKLSEFSGNREKLANSFTKTKNIYDDLLAKGTSFLLNRVIPLDLNFVWREFINNDWSNAAIEDYSRYMVTLKSVLKMPALTDASIKQQQEQPSTLAFILSQFNRDVYKWNFLDKVIDIITTNFVSNTIRLLQPVPPFSLAGSKRKFETRTVVNIGEQLLLDLELLKEIFHTLPESVSNDSDLRENTSYKRVKRHADNNIDQLLKFIKLLMAPLDSADDYYETYSKLTNNNPDSAVWSFVLALKGIPWDLALWKKLWSAYNLETDDTDEGSRPDSNRDLFIFKWDKVLLGQFENNLARMQDPNWSKFVRQDLKISPPVMKRIVSTPQIQQQKEEQKKQSLSVKDFVSHSRFFNRGT
Protein: Oligomycin resistance ATP-dependent permease YOR1 (ABC transporter YOR1) (ABC-type Cd(2+) transporter) (EC 7.2.2.2) (ABC-type glutathione-S-conjugate transporter) (EC 7.6.2.3) (Yeast oligomycin resistance protein 1) (P53049)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol. Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups. Required for tolerance to reveromycin A, tautomycin and leptomycin B. Required for oligomycin resistance. Required for rhodamine B resistance. Mediates the ATP-dependent efflux of rhodamine B. Involved in cadmium detoxification. Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex. Confers resistance to rhodamine 6G and to doxorubicin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10082567, ECO:0000269|PubMed:12107161, ECO:0000269|PubMed:9575223}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Pleiotropic ABC efflux transporter of multiple drugs
- Protein SNQ2
- Transcription factor PDR1
- ATP-dependent permease PDR15
- ATP-dependent permease PDR10
- Transcription factor PDR3
- Metal resistance protein YCF1
- ATP-dependent permease PDR12
- Bile pigment transporter 1
- ATP-dependent permease PDR11
Sequence:
MTITVGDAVSETELENKSQNVVLSPKASASSDISTDVDKDTSSSWDDKSLLPTGEYIVDRNKPQTYLNSDDIEKVTESDIFPQKRLFSFLHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYFMSIVFAILANCTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNIFASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGYPWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCSLFSSVWLSYWTENKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSMCSRSGIVENDFENRS
Protein: Tetrahydromethanopterin S-methyltransferase subunit B (EC 7.2.1.4) (N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit B) (Q59584)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tetrahydromethanopterin S-methyltransferase subunit E
- Tetrahydromethanopterin S-methyltransferase subunit C
- Tetrahydromethanopterin S-methyltransferase subunit H
- Tetrahydromethanopterin S-methyltransferase subunit G
- Tetrahydromethanopterin S-methyltransferase subunit D
- Tetrahydromethanopterin S-methyltransferase subunit F
- Tetrahydromethanopterin S-methyltransferase subunit A 1
- Tetrahydromethanopterin S-methyltransferase subunit A 2
- Methyl-coenzyme M reductase I operon protein C
- Methyl-coenzyme M reductase I subunit alpha
Sequence:
MEMLPLVKIAPEYNLTLDPSTGMIGAALGREVIILSMDEINEQIAALEATADDLINSLDPTTIPEGSYPGREGVYLTAGKLTNIVYGFILGLIILFALLL
Protein: Inhibin beta B chain (Activin beta-B chain) (P09529)
Organism: Homo sapiens (Human)
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular location: Secreted.
Interaction partners:
- Activin receptor type-2A
- Activin receptor type-1C
- Activin receptor type-2B
- Inhibin beta A chain
- Follistatin
- Bone morphogenetic protein receptor type-2
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
- Transforming growth factor beta-3 proprotein
Sequence:
MDGLPGRALGAACLLLLAAGWLGPEAWGSPTPPPTPAAPPPPPPPGSPGGSQDTCTSCGGFRRPEELGRVDGDFLEAVKRHILSRLQMRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYFFISNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNMVEKRVDLKRSGWHTFPLTEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA
Protein: Keratinocyte differentiation factor 1 (A2A9F4)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24075906}. Cell junction {ECO:0000269|PubMed:24075906}. Note=Localized at cell borders in single layered keratinocytes. Localized at cell borders in the basal and spinous layers but is more diffusely localized in the granular layer. Colocalized with actin near the cell membrane, especially in cellular protrusions.
Interaction partners:
- Receptor-interacting serine/threonine-protein kinase 4
Sequence:
MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC
Protein: Unk like zinc finger (A0A0A0MRZ1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGVCPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCHSRTEQQFHPEIYKSTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGSGSSSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVNIASLEKDLEEQDGHDLGAAGPRSLAGSAPVAIPGSLPRAPSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQPPPLRSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPSPILSAGPPSSSSASPNGAELARVRRQLDEAKRKIRQWEESWQQVKQVCDAWQREAQEAKERARVADSDRQLALQKKEEVEAQVKQLQEELEGLGVASTLPGLRGCGDIGTIPLPKLHSLQSQLRLDLEAVDGVIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCAATAPECPYCKGQPLQW
Protein: ASTRA-associated protein 1 (Q9UTR9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ASTRA complex probably involved in chromatin remodeling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RuvB-like helicase 1
- TEL2-interacting protein 1
- RuvB-like helicase 2
- SAGA complex/NuA4 acetyltransferase complex subunit Tra1
- DNA replication checkpoint protein tel2
- Tel2-interacting protein 2
- NuA4 acetyltransferase complex subunit Tra2
- Heat shock protein 90 homolog
Sequence:
MVVPTPFYVLRGHSSSVTSVLFDANEYLYSGDEAGFVICWCLTSMRPKCAWRAHTKTILGMQIVKGGALCTHGRDCRLVTWKIDFNCMTDNFMSLSKLAELQNYGPEASSETEKSSAFISIHSNIVVNSLTFCPFSYSPQSKIVVLCNTLNFEELDVYDDESLYHPQTHKEDCGKRLQTRIQPEESVGKTGSVMSTSVTVTDEKYVLLAAGYESGHVVQYICSLENVKTVTLDFKAVWKMVYAYKSHSQPVLSVEYAGSKLFSTGADDCICLHPTPSSIADDLGSLPHPIFRKTKHCGQQNIRIRSDNKILATAGWDGRGRVYSCQTLAPLAVLKYHSDGINSLAFHPGSNVIALASKDTRISLWKLY
Protein: 5'-nucleotidase (EC 3.1.3.5) (Ecto-5'-nucleotidase) (Q7SXU4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMMMNVLSALLLLFIHCQLCWSADFQLTLLHTNDVHARVEETNKDSGKCSKPPCFAGVSRRSTKIKEIRSKEKNVLLLDAGDQFQGTVWFNYYKGAEAAYFMNQLKYDAMALGNHEFDNGVDGLLKPFLQEVNCTVLSANIKADETLAPRISGYYFPYKIFTLGSEKVGVVGYTSAETPALSLPGPHLKFEDEITALQPQVDKLLTLGVNKIIALGHSGFLMDQMIAKKVQGVDVVIGGHTNTFLYTGDPPSTEVPAGPYPLMVKSDDGRQVPVVQAYAFGKYLGFLKVTFDANGNVLESTGNPILLNSSVEPDPDIQAKVDSWRMNLANYSSQQVGQTLVFLNGTFEECRFRECNLGNLICDAMVHHNIKYADELQWNHVSSCILNGGGIRGPIDERNRNGSITMEDLIAVLPFGGTFDLVQLNGSTLLEAFEHSVRRHGGNTGEFLQVSGFQVVYDLSKAPGSRVKSVKVLCTQCRVPHYEPLVPNKVYKVVLPSYLVDGGDGFTMIKEKKLKHDSGDLDISVVAGYISERKRVHPAVEGRFQFSSSCAGLRGYTSTVLLLWAVWLMLV
Protein: Embryogenesis-like protein (AtEML) (EMB-like protein) (Q9M9H3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activates gene expression by recruiting HAG1/GCN5 and triggering subsequent histone H3 acetylation of target genes promoters.
Subcellular location: Nucleus {ECO:0000305|PubMed:17151888}.
Interaction partners:
- Transcriptional adapter ADA2b
- Centromere/kinetochore protein zw10 homolog
- At3g24315
- Histone acetyltransferase GCN5
Sequence:
MRLHSAITLRNLFTRKSLRIPQNLSITASPLLIGDVSGQIKPSSTSHYSKSSLSEASSSSSSSLIFQIPNNASFFLENQRRYSTGSSSGSPPDVNKVVDEINLKFAEAREEIEMAMDAKETVYFNEEAECARDAVAEVLEMFQGLLGKVTEKEKASLQRSMGLKIEQLKAELEQLNE
Protein: Paxillin (F1NB68)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MKDALLADLESTTSHISKRPVFLTEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVIDPLDQWQPSVSRYGHQQPQSQSPIYSSSAKSSSASVPRDGLSSPSPRASEEEHVYSFPNKQKSAEPSPTMTSTSLGSNLSELDRLLLELNAVQHNPPSGFSADEVSRSPSLPNVTGPHYVIPESSSSAGGKAAPPTKEKPKRNGGRGIEDMRPSVESLLDELESSVPSPVPAITVSQGEVSSPQRVNASQQQTRISASSATRELDELMASLSDFKFMAQGKAGGSSSPPSTTPKPGSQLDTMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGVFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFINGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMGKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
Protein: G protein-coupled receptor kinase (EC 2.7.11.-) (Q1XHM0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Recoverin
- Recoverin a
- Recoverin b
- Recoverin 3
- Rhodopsin
- Green-sensitive opsin-2
- Rhodopsin
- Green-sensitive opsin-3
- Green-sensitive opsin-4
- Rhodopsin.
Sequence:
MDIGGLTTVVANSAYISARGSFDGTANPASNRDKKYHSKLKLPHITVCEDLRETLDLQFRSICVEQPIGKRLFQEYLETANEYKGPCRLWRDVEEYDTAEDKDRTQKAAKILQRYMEPSAKHFCPFLPENGITKVKERHQEAADDLFVEILACVFDFLKEVPFTFYLETMYFKRFLQWKWLEMQPVAEDWFLDFRVLGKGGFGEVSACQMRATGKLYACKKLNKKRLKKRKGYEGAMVEKRILARVHSRFIVSLAYAFQTKTELCLVMTIMNGGDLRYHIYNVDENNPGFSEPRACYYAAQIIQGLEHLHQKKIIYRDLKPENVLLDNEGNVRISDLGLAVELADGQEKTKGYAGTPGFMAPELLKGEEYDYSVDYFTLGVTLYEFIAAKGPFRTRGEKVENKEVKKRILNDPVTYSEKFSENAKSICEGLLAKEVDKRLGFKNGTCDEIRTHPFFSQLNWRKLDAGILPPPFVPDSKTVYAKDLDDVGAFSTVKGVCLEDDDKCFFDEFASGNISIPWQEEMIETGIYGELNVWGPGGAVPNDLRRESILEQPPKSSTCSVS