wanglab/gogpt-training-data huggingface dataset:
Protein: Secretion system effector (H9L4A0)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Interaction partners:
- Secretion system apparatus
- Secretion system apparatus protein
- Type 3 secretion system secretin
- Secretion system apparatus
- Salmonella pathogenicity island 2 protein C
- Secretion system effector
- Secretion system apparatus lipoprotein SsaJ
- SPI-2 type 3 secretion system needle filament protein
- Secreted effector protein SseB
- Secretion system chaparone
Sequence:
MTTLTRLEDLLLHSREEAKGIILQLRAARKQLEENNGKLQDPQQYQQNTLLLEAIEQAENIINIIYYRYHNSALVVSEQE
Protein: Replicative helicase loader DnaC (EC 3.6.4.-) (DNA replication protein DnaC) (P0AEF0)
Organism: Escherichia coli (strain K12)
Function: This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
Interaction partners:
- Chromosomal replication initiator protein DnaA
- Replication restart protein DnaT
- Replicative DNA helicase DnaB
- DNA primase
- Replication restart protein PriC
- Replication restart protein PriB
- DNA polymerase III subunit alpha
- Uncharacterized protein YjjA
- Single-stranded DNA-binding protein
- Beta sliding clamp
Sequence:
MKNVGDLMQRLQKMMPAHIKPAFKTGEELLAWQKEQGAIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFRNSGTSEEQLLNDLSNVDLLVIDEIGVQTESKYEKVIINQIVDRRSSSKRPTGMLTNSNMEEMTKLLGERVMDRMRLGNSLWVIFNWDSYRSRVTGKEY
Protein: Uncharacterized protein (Q389L5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MADRLPDVASRTILCPLFSRRLIQQTERSSALHILSSMCRLAIAQQRRYDAEIRGESGNCEKEGKVVTAVDEVTFAAQIVGSFINTSVLDLSTAFLPFSGTQRPHHLTILASRTQEATEYFHKLCKNEGCARVAPTAVRRTFSLLPAKREPRLSRHPLPFSRRYNLPACMTALHCVAQDIRPAEQRGLLRKLDTAGPALRVHSRDTLNEKLARKRRLEKKAVPSSLSRPAPQLIRRETSAPDAPPTPDPQCTTDQSEPVHSKPSSVPQEPIPNATWVKDGDLRVVNGKIVYFEEKLDDSDNKNDIPIEASEIETMKTRQDQSKKKKDSTKKSNRIIDKNVRKDRKHNASPKIKHNRHPQQSIPLKSREELIEMVEALDVSSRLRQTFWIGLAKREDK
Protein: Histone deacetylase complex subunit SAP30L (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) (Q6NYV5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Required for normal expression of numerous target genes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9HAJ7}.
Interaction partners:
- BRMS1 transcriptional repressor and anoikis regulator.
- Histone deacetylase complex subunit SAP130a
- Histone deacetylase complex subunit SAP18
- Paired amphipathic helix protein Sin3a
- AT-rich interactive domain-containing protein 4A
- Family with sequence similarity 60, member A
- SIN3-HDAC complex-associated factor,-like.
- Histone-binding protein RBBP4
- Inhibitor of growth protein
- Histone deacetylase 1
Sequence:
MNGFSTEEDSHDGPPAPPFFGQSCCLIEDAERCGRPAGNASFSKRIQKSISQRKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGESPDHEVEVPEVDLFQLQVNTLRRYKRHYKIQTRPGLNKAQLAETVSRHFRNIPVNEKETLTYFIYMVKSSKSRLDQKSDSSKQVE
Protein: GH23568p (Parvin, isoform A) (Parvin, isoform B) (Q9VWD0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Integrin linked kinase, isoform A
- LIM domain-containing protein
- Paxillin, isoform F
- Ras suppressor protein 1
- Rhea, isoform B
- Rho-type guanine nucleotide exchange factor, isoform F
- Vinculin
- dual-specificity kinase
- Unc-112-related protein
- Alpha-actinin, sarcomeric
Sequence:
MSTLNRPKSPHTPTAIKKGEKEDSFWDKFSTLGRKRGTREVKKVQEEGKYAIDSPGSPSQYDIPPEDYALREHEQRAVIDPQSISDPQVIKLQRILVDWINDELAEQRIIVQHLEEDMYDGQVLHKLWEKLTGKKLDVPEVTQSEQGQHEKLNIVLKAVNHTLGFHQKIPKWSVASVHSKNIVAILHLLVALVRHFRAPVRLPENVFVTVVIAEKNAGVLNAQKFQEQITSEYDDLGMRCEKDAFDTLIDCAPDKLAVVKKSLITFVNKHLAKLNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQDVDQMVSNVAFAFDLMQDVGLPKPKARPEDIVNMDLKSTLRVLYSLFTMFRDFA
Protein: Ribonuclease P protein subunit p38 (RNaseP protein p38) (P78345)
Organism: Homo sapiens (Human)
Function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10444065}.
Interaction partners:
- Ribonuclease P protein subunit p25
- Ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p40
- Ribonuclease P protein subunit p21
- Ribonuclease P protein subunit p29
- Ribonuclease P protein subunit p30
- Ribonuclease P protein subunit p20
- Ribonucleases P/MRP protein subunit POP1
- Ribonuclease P protein subunit p14
- Ubiquitin-like protein FUBI
Sequence:
MAAAPQAPGRGSLRKTRPLVVKTSLNNPYIIRWSALESEDMHFILQTLEDRLKAIGLQKIEDKKKKNKTPFLKKESREKCSIAVDISENLKEKKTDAKQQVSGWTPAHVRKQLAIGVNEVTRALERRELLLVLVCKSVKPAMITSHLIQLSLSRSVPACQVPRLSERIAPVIGLKCVLALAFKKNTTDFVDEVRAIIPRVPSLSVPWLQDRIEDSGENLETEPLESQDRELLDTSFEDLSKPKRKLADGRQASVTLQPLKIKKLIPNPNKIRKPPKSKKATPK
Protein: Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) (P22443)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Subcellular location: Membrane; Peripheral membrane protein.
Interaction partners:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- Estradiol 17-beta-dehydrogenase 1
- 17-beta-hydroxysteroid dehydrogenase type 3
- Steroid 17-alpha-hydroxylase/17,20 lyase
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- Estradiol 17-beta-dehydrogenase 2
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- Cytochrome P450 1A1
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
Protein: E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B) (A2A7Q9)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity).
Subcellular location: Cytoplasmic granule membrane {ECO:0000250|UniProtKB:Q6ZMZ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6ZMZ0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6ZMZ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6ZMZ0}.
Interaction partners:
Sequence:
MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE
Protein: Smooth muscle archvillin (Q6U1J6)
Organism: Mustela putorius furo (European domestic ferret) (Mustela furo)
Interaction partners:
Sequence:
MKRKERIARRLEGIETDTQPILLQSCTGLVTHRLLEEDTPRYMRATDPASPHTGRSNEEEDTSDSSVEKQTRSKLCTETSGIHAESSCGSGLMDTQALESKAERIARYKAERRRQLAEKYGIALDSEADSESPSRYTKSRKDADAADKGGGKGDRQAEPGKESCSLYSKDYALSGGDGLSDTEVLLNVENQRRGQEPSTTGQARDLAPTVESSSSFPFPGRDCAFSEVPRSPKQMHSVSLSSPRPPASPSHSAGDPPLPPEARTRVKVREKMVKEESARSSPEVASEPFTQRRHQPVPIHCSSFQSENSAFDRVLSKAASSAGQPIRDYVQPADPIHTATLVTSEILKNVSECSWGGSAAQNVRKPPTLKVLESERRDTPVLHICESKAEEDMLFTEALEKSRKSLLALEDHGLMRSHEDPSGNDDVGKPAGSPVPSEHQKEPESLSHPPPSQQLPAERISRQEMVLYVQSQPVSQDARATGHRQEALVKKRKVLTRSLSDYTGPPPLQALKGKDPASRQELEPQSYKAEGPPPEVGVLDTKVSVAQLRNAFLESVHASKKPELSASHSEMPAAEDEEKVDERAKLSVAAKRLLFREMEKSFDEKNVPKRRSRNAAVEQRLRRLQDRSHTQPVTTEEVAIAATLQASAHHKALARDQANEGKDSAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDMRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPTVNTSVSTVASMVTPMYAGDLRTKLSVDDNTSATDYKFPSSIENSDSPVRSILKSQAWQPSAESSGSRGMLREFGEAESKRVLTGGDGGKKYGSFEEAEPPCPTFNRVREGDSHKEPKYAVPRKGSLELGHPPVAHLGDELKEFSMGKSLAQGSPDLKDRQHFEEKVDMENVPRRKFSLRAAEFGEPPSEQTGLAAGKTVAPTAAPVSWRQQDPAEPGQEKYSRSPCAMFAAGEIKVPAVEGILDSAGKTMSIKERLALLKKSGEEDWKNRLIRKQEYGKASVTSSLHIQETEQSLKKKRVTESRESQMTIEERKHLISVREEAWKTKGKGAANDSTQFTVAGRMVKKGLASPTAITPVASPLCSKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGETVLTVTGKSVKEVMKLDDDETFARFYRSMDDTIPRSPVELDEDFDVIFDPYAPKLPLWAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSANSNFSEVTLAGLASKENFSNISLRSVNLTEQNSNNSAVPYKKLMLLQIKGRRHVQTRLVEPRASSLNSGDCFLLLSPHYCFVWVGEFANVIEKAKASELASLIQTKRELGCRATYVQTIEEGINTHTHAAKDFWKLLGSQTSYQSAGDPKEDELYETAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRPNEKSASELAQPKEDPRAEAKPYDVALMVPVPQATAGTVLDGVNVGRGYGLVEGDDRRQFEIASVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKYMVSTAVGSRQKGEHSVRVAGKEKCVYFFWQGRQSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENAQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGNFNFTPRLFILSSSSGDFAATEFMYPARDPSVVNSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPTENKITGSARIRWASDRKSAMETVLRYCKGKNIKRPPPKSYLIHAGLEPLTFTNMFPSWEHREDIAQITELDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTREEYNTLPAWKQVNLKKAKGLF
Protein: Patellin-6 (Q9SCU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier protein that may be involved in membrane-trafficking events associated with cell-plate formation during cytokinesis. Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly membrane-associated. Also cytoplasmic (By similarity). {ECO:0000250}.
Interaction partners:
- Sec14p-like phosphatidylinositol transfer family protein
- SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein
- AT3g10210/F14P13_19
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH14
- At4g35750
- Appr-1-p processing enzyme family protein
Sequence:
MDASLSPFDHQKTQNTEPKKSFITSLITLRSNNIKEDTYFVSELKPTEQKSLQELKEKLSASSSKASSMWGVSLLGGDDKADVILLKFLRARDFKVADSLRMLEKCLEWREEFKAEKLTEEDLGFKDLEGKVAYMRGYDKEGHPVCYNAYGVFKEKEMYERVFGDEEKLNKFLRWRVQVLERGVKMLHFKPGGVNSIIQVTDLKDMPKRELRVASNQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKEGNAAETLYKFIRPEDIPVQYGGLSRPTDSQNGPPKPASEFSIKGGEKVNIQIEGIEGGATITWDIVVGGWDLEYSAEFVPNAEESYAIVVEKPKKMKATDEAVCNSFTTVEAGKLILSVDNTLSRKKKVAAYRYTVRKSTTTV
Protein: Van1p (A0A1D8PKT1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Alpha-1,6-mannosyltransferase
- Mannan polymerase complex subunit MNN9
- Alpha-1,6-mannosyltransferase
- Alpha-1,6-mannosyltransferase
- Initiation-specific alpha-1,6-mannosyltransferase
- Anp1p
- GDP-Man:Man
- GDP-mannose transporter
Sequence:
MSFRALTPDLYGKKSKNSDLPVFNKFTPKKHSDRVLIKRVLYTLVFLLVTYTIYSRVLTGDSRIPQSQDRQQSPTNDNNHEVYKVTKDGVYKQEVTGVVEEVEEEELKEVTTEDLYKSNVDIFDLNDYQGSQEGAKNGDILLFLMPLRNAEHVLPMAFYNLMNLTYDHRLIDIAFLVSDCSPDDTTLETVFEYSVALQNGTLVDKLKHEEELKNSGNVRGTSDLYQSYMEPSYIESVKKAYSNPESHHPNYRTPFRSVTIFKKDFGQVIGQGFSDRHAVKVQGIRRKLMGRARNWLTSAALKPYHSWVYWRDADIETCPGDVIEELMSHNYDVMVPNVWRPLPTFLGNEQPYDLNSWVESDAGLELAKTLNEDDVIVEGYAEYPTWRAHLAYIRDANGDPREVIDLDGVGGVSILARAKIFRQGVHFPAFTFLNHAETEAFGKMAKKMGFSVGGLPHYTIWHIYEPSEDDLKEIARLERKKRRQKS
Protein: Invertase/pectin methylesterase inhibitor family protein (Plant invertase/pectin methylesterase inhibitor superfamily protein) (Putative pectinesterase) (O80720)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g50030
- At1g10770
- Probable pectinesterase 50
- Probable pectinesterase/pectinesterase inhibitor 21
- At5g48140
- Bnm1 like protein
- Probable pectinesterase 67
- Expressed protein
- Glycoside hydrolase family 28 protein/polygalacturonase family protein
- Probable pectinesterase 49
Sequence:
MNTPIKLAFLILCIALTATAFIVPAKRDAVSPHHQKAVDGICSVVQDKRLCSITLRNVPSDDPAVLVRYLATAAEASVKKGLKFLSGIKPKYKGNAFATTCITGCEKQLHNALDDFADFWKAAGKNLTSMAENYFTCKKKMTSIFTYHSTCLDDIYDKTLHKVVEGGIGLGKRMSGESVDVFAGMGKVFNTFNIKTKLNQKDTDTLLPPPLSFYYY
Protein: Lon protease homolog, mitochondrial (EC 3.4.21.53) (O44952)
Organism: Caenorhabditis elegans
Function: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mitochondrion.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 1, mitochondrial
- AFG3-like protein spg-7
- Transcription factor atf-4 homolog
- ATP-dependent zinc metalloprotease YME1 homolog
- Stress activated transcription factor atfs-1
- Chaperonin homolog Hsp-60, mitochondrial
- GrpE protein homolog
- GTPase Era, mitochondrial
- Heat shock protein 70
- ATP-dependent Clp protease ATP-binding subunit clpX-like
Sequence:
MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ
Protein: Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) (Q99K30)
Organism: Mus musculus (Mouse)
Function: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H6S3}. Cell projection, stereocilium {ECO:0000269|PubMed:23918390}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells. {ECO:0000269|PubMed:23918390}.
Interaction partners:
- Twinfilin-2
- Whirlin
- Espin
- Unconventional myosin-XV
- Myosin-IIIa
- Espin-like protein
- Myosin-IIIb
- Epidermal growth factor receptor kinase substrate 8
- Peripheral plasma membrane protein CASK
- Gelsolin
Sequence:
MSQSASMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAIASVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFPLPTVQHSQTVLNQLRYPSVLLLVCQDSDQNKPDIHFFHCDEVEAELVQEDIESALADYRLGKKMRPQTLKGHQEKIRQRQSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPVPFSEPGYRRRESQDEEPRAVLAQRIEKETQILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIARSVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKNRLSVRHSPKHSLSSESQAPEDIAPPGSSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQKYWGPASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVCGEEGSRVYSQLTVQKAFLEKQQSGSELEKLMSKIRRAEDSYTSQHTSPESEGAPHL
Protein: Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) (P41093)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein eS19A
- IP17351p
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL15
- 40S ribosomal protein S15
Sequence:
MRAKGLLKEYEVVGRKLPSEKEPQTPLYKMRIFAPDNIVAKSRFWYFLRQLKKFKKTTGEIVSIKQVYETSPVKIKNFGIWLRYDSRSGTHNMYREYRDLTVGGAVTQCYRDMGARHRARAHSIQIIKVDSIPAAKTRRVHVKQFHDSKIKFPLVQRVHHKGNRKLFSFRKPRTYFQ
Protein: Neuronal pentraxin with chromo domain (Q6TKP2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGPGGGSTAQGTGALARPKVPSRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLAPSTAGKADVASSGPGLLLATPAAAPFDAHSSSSSGCPSPTLQSSDPDDAPPKLLPETLSDLSIPPEAAATGQRVPPDVTGAADQALHTALEPTGAGSSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCSPEDFEQELPARGNLSSAPAPAMPTALHSKMDELECQLLAKVLALEKERAALSHGSHQQRQEVEKELNALQGRVAELEHGSSAYSPPDAFKVSIPIRNNYMYARVRKALPELYAFTACMCVRSRSGGSGQGTPFSYSVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICISWTTRDGLWSAYQDGELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGMANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA
Protein: Small ribosomal subunit protein eS7 (40S ribosomal protein S7) (Q5AJ93)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS7A is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS17
Sequence:
MSSKILSENPTELELKVAQAFVDLESQADLKAELRPLQFKSIKEIDVNGGKKALAVFVPPPSLQAYRKVQTRLTRELEKKFPDRHVVFLAERRILPKPARKARKQQKRPRSRTLTAVHDKILEDLVFPTEIIGKRVRYLVGGNKIQKVLLDSKDSTAVDYKLDSFQQLYSKLTGKQVVFEIPGESH
Protein: Probable phospholipid-transporting ATPase 7 (AtALA7) (EC 7.6.2.1) (Aminophospholipid flippase 7) (Q9LVK9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in transport of phospholipids and in regulation of pollen plasma membrane lipid asymmetry.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9SLK6}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q9SLK6}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ALA-interacting subunit 1
- Adenine phosphoribosyltransferase 4
- ALA-interacting subunit 3
Sequence:
MGRRRIRSRIRKSHFYTFKCLRPKTLEDQGPHIINGPGYTRIVHCNQPHLHLAKVLRYTSNYVSTTRYNLITFLPKCLYEQFHRVANFYFLVAAILSVFPLSPFNKWSMIAPLIFVVGLSMGKEALEDWRRFMQDVKVNSRKATVHRGDGDFGRRKWKKLRVGDVVKVEKDQFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRCLDVTLPLERDDTFQSFSGTIKCEDPNPNLYTFVGNLEYDGQVYPLDPSQILLRDSKLRNTSYVYGVVVFTGHDTKVMQNSTKSPSKRSRIEKRMDYIIYTLFALLVLVSFISSLGFAVMTKMHMGDWWYLRPDKPERLTNPRNPFHAWVVHLITAVLLYGYLIPISLYVSIELVKVLQATFINQDLQMYDSESGTPAQARTSNLNEELGQVDTILSDKTGTLTCNQMDFLKCSIAGTSYGVRASEVELAAAKQMAIDLDEEQGEEVTHLPRTRGRMHGYAKMPSKTSSDIELETVITATDEGDQTQSTGIKGFSFEDQRLMGGNWLNEPNSDDILMFLRILAVCHTAIPEVDEDTGKCTYEAESPDEVAFLVAAGEFGFEFTKRTQSSVFISERHSGQPVEREYKVLNVLDFTSKRKRMSVIVRDEKGQILLLCKGADSIIFERLSKNGKNYLEATSKHLNGYGEAGLRTLALSYRKLDETEYSIWNSEFHKAKTSVGADRDEMLEKVSDMMEKELILVGATAVEDKLQKGVPQCIDKLAQAGLKIWVLTGDKMETAINIGYACSLLRQGMKQIYIALRNEEGSSQDPEAAARENILMQIINASQMIKLEKDPHAAFALIIDGKTLTYALEDDIKYQFLALAVDCASVICCRVSPKQKALVTRLAKEGTGKTTLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQMICYFFYKNITFGLTLFYFEAFTGFSGQAIYNDSYLLLFNVILTSLPVIALGVFEQDVSSEVCLQFPALYQQGPKNLFFDWYRIIGWMANGVYASVVIFSLNIGIFHVQSFCSGGQTADMDAMGTAMFTCIIWAVNVQIALTMSHFTWIQHVLIWGSIVTWYIFLALFGMLPPKVSGNIFHMLSETLAPAPIFWLTSLLVIAATTLPYLAYISFQRSLNPLDHHIIQEIKHFRIDVQDECMWTRERSKAREKTKIGVTARVDAKIRQLRGRLQRKHSILSVMSGLSGVSASTDTTSTTQHS
Protein: Dehydrodolichyl diphosphate synthase complex subunit SPAC4D7.04c (EC 2.5.1.87) (Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)) (O14171)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: With nus1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35196}; Peripheral membrane protein {ECO:0000250|UniProtKB:P35196}.
Interaction partners:
- Dehydrodolichyl diphosphate synthase complex subunit nus1
- Farnesyl pyrophosphate synthase
- Geranylgeranyl pyrophosphate synthase
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein farnesyltransferase subunit beta
- Decaprenyl-diphosphate synthase subunit 1
- Squalene synthase
- V-type proton ATPase subunit a
- Isopentenyl-diphosphate delta-isomerase
- Saccharopine dehydrogenase [NADP
Sequence:
MGNLSGWFIHCPPLQWTLDQLETMMINTIKRGKVPQHIAFVMDGNRRWARQRRMETIEGHSSGFEALKSLLKVCLKLGVKEVSAFTFSIENFKRSKYEVDMLMEIAKNSLTQITAHGDLVDQYGIRIRIVGDLSRLQPDVLETALKAVEITKHNTKATLNVCFPYTSRHEIATSVQSIVKMAEDGTITPEDIDEDIFEKNLLIKDSLPLDLLIRTSGVERLSDFMLWQCHKNTEIKFIDFYWPDFSIWKFFPMLIQYQLQNQPA