wanglab/gogpt-training-data huggingface dataset:
Protein: RRP12-like protein (Q5JTH9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Bystin
- Pre-rRNA-processing protein TSR1 homolog
- Nucleolar protein 14
- Nucleolar complex protein 4 homolog
- Nucleolar protein 58
- KRR1 small subunit processome component homolog
- Serine/threonine-protein kinase RIO2
- Periodic tryptophan protein 2 homolog
- RNA cytidine acetyltransferase
- Protein RRP5 homolog
Sequence:
MGRSGKLPSGVSAKLKRWKKGHSSDSNPAICRHRQAARSRFFSRPSGRSDLTVDAVKLHNELQSGSLRLGKSEAPETPMEEEAELVLTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFMDIMSAQASSGSTSVLRWVLSCLATLLRKQDLEAWGYPVTLQVYHGLLSFTVHPKPKIRKAAQHGVCSVLKGSEFMFEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLSHVLVTACAMQAFHSLFHARPGLSTLSAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQWDLGLGHLPRFFGTAVTCLLSPHSQVLTAATQSLKEILKECVAPHMADIGSVTSSASGPAQSVAKMFRAVEEGLTYKFHAAWSSVLQLLCVFFEACGRQAHPVMRKCLQSLCDLRLSPHFPHTAALDQAVGAAVTSMGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKAMDLAQAGSTVESKIYDTLQWQMWTLLPGFCTRPTDVAISFKGLARTLGMAISERPDLRVTVCQALRTLITKGCQAEADRAEVSRFAKNFLPILFNLYGQPVAAGDTPAPRRAVLETIRTYLTITDTQLVNSLLEKASEKVLDPASSDFTRLSVLDLVVALAPCADEAAISKLYSTIRPYLESKAHGVQKKAYRVLEEVCASPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCLLHIVRKLSAEHKEFITALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEEALQCYLVLIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKRLLPEEYHRVLVNIRKAEARAKRHRALSQAAVEEEEEEEEEEEPAQGKGDSIEEILADSEDEEDNEEEERSRGKEQRKLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGRKKDHGFKVSADGRLIIREEADGNKMEEEEGAKGEDEEMADPMEDVIIRNKKHQKLKHQKEAEEEELEIPPQYQAGGSGIHRPVAKKAMPGAEYKAKKAKGDVKKKGRPDPYAYIPLNRSKLNRRKKMKLQGQFKGLVKAARRGSQVGHKNRRKDRRP
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal (EC 1.1.1.8) (Q4QHG4)
Organism: Leishmania major
Subcellular location: Glycosome {ECO:0000250}.
Interaction partners:
- Dihydroxyacetonephosphate acyltransferase
- Glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase-like protein
- Glycerol-3-phosphate acyl transferase
- Dihydroxyacetone kinase 1-like protein
- Alkylglycerone-phosphate synthase
- Putative phosphatidic acid phosphatase
- Putative lipin
- Diacylglycerol kinase
Sequence:
MISTKRHINTNELLHLSKAVVFGSGAFGTALAMVLSKKCREVCVWHIKEEEARLVNEKRENDLYLRGVQLASNIIFTSDVDEAYKGAELILFVIPTQFLRGFFQKSGGNLIAYAKARQVPVLVCTKGIERSTLKFPAQIVGEFFPSNLLSVLAGPSFAIEVATGVFTCVSVASADINVARRLQRIMTTGDRSFVCWATTDTVGCEVASAVKNVLAIGSGVANGLGMGLNARAALITRGLLEIRDLTAALGGDGSAIFGLAGFGDLQLTCSSELSRNFTVGKKLGKGLSLEEIQRTSKAVAEGVATAEPLVRLAQQLKVTMPLCQQIYEVVYKKKNPRAAIADLLSCGLQDEGLPPLFKKSAATPSKL
Protein: 39S ribosomal protein L55, mitochondrial (Q9TYJ8)
Organism: Caenorhabditis elegans
Interaction partners:
- Large ribosomal subunit protein mL43
- SRR1-like domain-containing protein
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein mL51
- Small ribosomal subunit protein bS16m
- Mitochondrial Ribosomal Protein, Small
- Large ribosomal subunit protein mL41
- Small ribosomal subunit protein uS14m
- Mitochondrial Ribosomal Protein, Small
- Large ribosomal subunit protein mL49
Sequence:
MFLQMNTQISMRNLLTSCSKAITAERNNAWRASLGKISRRDYLHRYQVKFIRPDGSTIMVPAAEPRQTFQSAVDLKQLSEDERRQRLAARKPKAKITKTEVIDDTFDESEYMKFWSAPGQKSTKK
Protein: Protein RER1 (Q5T091)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWDASVCGDGRCSCKAGGGRQVPGAGCRCGANLLSPLEGMRLPRASLWLWSVLSSTLSTSRCSGRFW
Protein: Plant thionin family protein (A8MRY8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTTQTCNVFMFVAILTMMFSAHIAQSNSLTMCVKHCAHNRCLKAAKNSTPEICDETCKKICNNQLFGGKKFIVPPPKGSSHFCRWLPQFC
Protein: Rifin (Q8I4P7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLLHYCKVLLFSLPLNILVYSKNKPYITPRHTPNTTSRVLSECDINTSIYHNDPDMKSVKENFDRQTSQRLREYDERLQDKRQKRKEQRDKNIQKIIHKDKMEKKLAEKIEKGCLMCACGLGSVAGSVGLLGGFGIYVSKSAALATAIAEGAETAKAAGEAARIPAAIDAVIKGITKVFGVSTLGVQRLESLFTANIYNNVTMIARAINEQYNPSSCILPIGGSGADKSICPWVMEKYLPAQNIPEMTRGGALSMNDVIETAVKSIVTDAKTVAETAAKKATEEAIKASTDAVESAYAACQTAIIASVVAILVIVLVMMIIYLILRYRRKKKMNKKQQYTKLLNQ
Protein: Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) (Q568P9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20859253}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000269|PubMed:20859253}.
Interaction partners:
- Mitochondrial cardiolipin hydrolase
- Tudor and KH domain-containing
- ATP-dependent RNA helicase TDRD9
- Ankyrin repeat, SAM and basic leucine zipper domain-containing 1.
- Tudor domain-containing protein 1
- peptidylprolyl isomerase
- ALK and LTK ligand 1.
- Piwi-like protein 2
- ALK and LTK ligand 2a
- ALK and LTK ligand 2b
Sequence:
MTATPFSPPLYMQRYQFVIDYVKTYRPRKVIDFGCAECCLLKKLKFHRNGIQLLVGVDINSVVLLKRMHSLAPLVSDYLQPSDGPLTIELYQGSVMEREPCTKGFDLVTCVELIEHLELEEVERFSEVVFGYMAPGAVIVTTPNAEFNPLLPGLRGFRNYDHKFEWTRAEFQTWAHRVCREHGYSVQFTGVGEAAGHWRDVGFCTQIAVFQRNFDGVNRSMSNAEHLEPSVYRLLYRVVYPSLCDNNIYQKTLINEVLYEAQHLRQQWLIRENMNNNAHFYSPPLMEALHHGAEGNACEQQPVYQQGGIICVPLARVWSCPRVQALCGSLQRLREKLLEDERVRMSADGSALNLPADDDDDNVEEEEEEEEEENQQNVKAVSGAVNNMEEDWDRELGSYGDE
Protein: Precursor of the S-layer proteins (Q183M8)
Organism: Clostridioides difficile (strain 630) (Peptoclostridium difficile)
Interaction partners:
- Protein translocase subunit SecA 2
Sequence:
MNKKNIAIAMSGLTVLASAAPVFAATTGTQGYTVVKNDWKKAVKQLQDGLKDNSIGKITVSFNDGVVGEVAPKSANKKADRDAAAEKLYNLVNTQLDKLGDGDYVDFSVDYNLENKIITNQADAEAIVTKLNSLNEKTLIDIATKDTFGMVSKTQDSEGKNVAATKALKVKDVATFGLKSGGSEDTGYVVEMKAGAVEDKYGKVGDSTAGIAINLPSTGLEYAGKGTTIDFNKTLKVDVTGGSTPSAVAVSGFVTKDDTDLAKSGTINVRVINAKEESIDIDASSYTSAENLAKRYVFDPDEISEAYKAIVALQNDGIESNLVQLVNGKYQVIFYPEGKRLETKSANDTIASQDTPAKVVIKANKLKDLKDYVDDLKTYNNTYSNVVTVAGEDRIETAIELSSKYYNSDDKNAITDKAVNDIVLVGSTSIVDGLVASPLASEKTAPLLLTSKDKLDSSVKSEIKRVMNLKSDTGINTSKKVYLAGGVNSISKDVENELKNMGLKVTRLSGEDRYETSLAIADEIGLDNDKAFVVGGTGLADAMSIAPVASQLKDGDATPIVVVDGKAKEISDDAKSFLGTSDVDIIGGKNSVSKEIEESIDSATGKTPDRISGDDRQATNAEVLKEDDYFTDGEVVNYFVAKDGSTKEDQLVDALAAAPIAGRFKESPAPIILATDTLSSDQNVAVSKAVPKDGGTNLVQVGKGIASSVINKMKDLLDM
Protein: Cytochrome P450, family 3, subfamily A, polypeptide 65 (Q32LT1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
Sequence:
MFFSAETWTLLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGTMLRYKDGFHVFDMDCFEKYGRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAVSIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVDYETLMSMDYLDAALSESLRLFPVAARLERVCKKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNGLLSPKDPIKLKLQPRKLSQSPDVCNNNQKS
Protein: Nucleoid-associated protein EspR (ESX-1 transcriptional regulatory protein EspR) (P9WJB7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:22479184}.
Interaction partners:
- ESX-1 secretion-associated protein EspA
- Conserved protein
- ESX-1 secretion-associated protein EspC
- Possible two component system response transcriptional positive regulator PhoP
- ESX-1 secretion-associated protein EspB
Sequence:
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSGATMAALANFFRIKAAYFTDDEYYEKLDKELQWLCTMRDDGVRRIAQRAHGLPSAAQQKVLDRIDELRRAEGIDA
Protein: AUGMIN subunit 3 (Q0WQE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in microtubules reorganization during spindle and phragmoplast development. Required for gamma-tubulin localization during mitosis.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21750235}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:21750235}. Note=Preferentially localizes to microtubules minus ends. {ECO:0000269|PubMed:21750235}.
Interaction partners:
- AUGMIN subunit 1
- AUGMIN subunit 6
- HAUS augmin-like complex subunit
- Putative RRM-containing protein family protein)
- LYR motif protein
- AUGMIN subunit 4
- AUGMIN subunit 2
- AUGMIN subunit 5
- AUGMIN subunit 7
- Tubulin gamma-2 chain
Sequence:
MSSARLCSLVAELGYEGAGKLDPDSFEWPFQYDDARPILDWICSSLRPSNVLSLAELSLYEQFQRDGKLLEGDDLDQAYDSISAFSSRRNNQEAVFGAEESIKEVRDATLAHKAEALELQRQLRRLQTQYDLLTGQSSALIQGRRARVAATSAVSGQITAIEDSLSARNLQMNGVLGRLASTSQELAHYHSGEEDGIYLAYSDFHAYLAGDSACTKELNQWFAKQLDTGPYRLVAEEGKSKCSWVSLDDTSNMLRDLEKSQHQRVAELQRLRSIFGTSERQWIEAQVENAKQQAILLTLKSQVTSVEAHIHFDLHSLRRKHADLVEEISTLYQKEEKLLSETIPELCWELAQLQDTYILQGDYDLKVMRQELYISKQKVFINHLVNQLARHQFLKLACQLEKKNMLGAFSLLKVIESELQGYLSATRSRVGRCSALIQAASDVQEQGAVDDRDSFLHGVRDLLSIHSNTQAGLSTYVSAPAIIQQIVALQSDLSSLQSDLENSLPDDRNRCINELCTHIQNLQQLLFASSTTAQPILTPWPLMKELDEMGKINSKLSTAVEEVTLEHRNKREIVKHHAKDVELQRRVFVDFFCNPERLRNQVRELNALVRARQASSS
Protein: Intermediate cleaving peptidase 55 (EC 3.4.11.26) (Q10439)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}; Matrix side {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mitochondrial intermediate peptidase
- Probable mitochondrial-processing peptidase subunit alpha
- Mitochondrial inner membrane protease atp23
- Lon protease homolog, mitochondrial
- U6 small nuclear RNA
- ATPase synthesis protein 25
- Wtf element wtf11
Sequence:
MSGYIRTLFIRNRFSNYRLRSQIIKYKYSNVSYLNKSALRCGQATDSTHPHILQPGELTPRISAQEYKTRRDRVASLLEDNDFMIVTSAPVRHMCGAAFYEYHQDPNFYYLTGCLEPNAVLLMFKNGASGSYDCSLYLPSKNPYIEKWEGLRTGSTLGKKLFQIENVYDSSLASSVINALGKKSNRIFYNYQTGYLSKMPAASAPEFIQDTLTKLFRTSTQRSVDELLHPLRSIKSTAELECMKEAANISSNVYREIMRKRFEKEAEMSAEFNYRFCIGGCDRSAYVPVVAGGKNGLTIHYTINNDIFRPDEMVLVDAGGEFGGYVTDISRTWPINGKFSTVQRDLYQAVLNVQKKCIKYCCTSNGWSLADIHFESVKLMHEELKQVGIHGTKREITDILYPHSIGHEIGLEIHDCSTNNGYQPLRKNQVITIEPGLYVPEEDGWPQWAQGIAIRIEDSVIVGDDKPFVLTSAAPKEIEEIEALKK
Protein: Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 (EC 3.6.4.13) (Masculinization of germline protein 5) (Sex determination protein mog-5) (Q09530)
Organism: Caenorhabditis elegans
Function: Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor CWC22 homolog
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor syf-2
- TPR_REGION domain-containing protein
- Pre-mRNA-splicing factor CWC25 homolog
- peptidylprolyl isomerase
- RNA helicase
- Pre-mRNA-splicing factor RBM22
- Probable ATP-dependent RNA helicase DDX23
Sequence:
MDQLEHLSLVSKVLSEVENHFGVVEKDVAEFVIHLAQENPTFDKLKKALDSQGLGDQFDDSLTATILRIVQSMTAVKKKNKKGGDSKEDIKDSHKITLISDAKEEIKARLPALAMANTAKEKEDNEDDLMAQLEKMEGRYESEKRLQKESDSKRNRSRSRSRSRDRKRRRSRSGDRDRRRRSRSREDRRDRDRRDRDRDRDRGRGDRRGDDRQRDRRDRRDDGGARKSEVAEIGKIYDGRVNSIQSFGAFITLEGFRQKQEGLVHISQIRNERVQTVADVLKRGENVKVKVNKIENGKISLSMKEVDQNSGEDLNPRETDLNPDAIGVRPRTPPASTSSWMNPEASGVGQGPSTSIGGGKARVRISTPERWELRQMQGAGVLTATDMPDFDEEMGVLRNYDDESDGEDIEIELVEDEPDFLRGYGKGGAEIEPVKVVKNPDGSLAQAALMQGALSKERKETKIQAQRERDMDTQKGFSSNARILDPMSGNQSTAWSADESKDRNNKMKEMPEWLKHVTAGGKATYGRRTNLSMVEQRESLPIFALKKNLMEAMIDNQILVVVGETGSGKTTQMTQYAIEAGLGRRGKIGCTQPRRVAAMSVAKRVAEEYGCKLGTDVGYTIRFEDCTSQDTIIKYMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHTDVLFGLLKAAARKRPELKLIITSATLDSVKFSEYFLEAPIFTIPGRTFPVEILYTREPESDYLEAAHITVMQIHLTEPPGDVLVFLTGQEEIDTSCEVLYERMKSMGPDVPELIILPVYGALPSEMQTRIFDPAPAGKRKVVIATNIAETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPISQAAAKQRSGRAGRTGPGKCYRLYTERAFRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDFDFMDAPPLDSMITALNTLHTLSALDGDGLLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAMLNVQNIFYRPKEKQDHADQKKAKFHQPEGDHLTLLAVYNSWKNHHFSQPWCFENFIQVRSMKRAQDIRKQLLGIMDRHKLLMVSCGRDVSRVQKAICSGFFRNAAKRDPQEGYRTLTDGQNVYIHPSSACFQQQPEWVVYHELVMTTKEYMREVTAIDPKWLVEFAPSFFKIGDSTKLSTFKRNQKIDPLFDKYADANAWRITRVKKRIYNPNK
Protein: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (Phosphoinositide-3-kinase, class 2, beta polypeptide) (A2RUF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGTL
Protein: PITPNM family member 3 (A0A8I5ZTJ8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MAKAGSAGGPSPGGGAPWHLRNVLSDSVESSDDEFFDAREEVAEGKNAILIGMSQWSSNDLVEQIETMGKLDEHQGELYRVSLRRQKFPAQGSIEIHEDVEEGCSQRSCKTHVLLLVLHGGNVLDTGSGDPSCKAADIHTFSSVLEKVTRAHFPAALGHILIKFVPCPAICSEAFSLVSNLNPYSHDEGCLSTSQDHVPLAALPLLAISSPQYQDAVATVIERANHIYGEFLKSSDGIGFNGQVCLIGDCVGGLLAFDAICYSAGPSGDSPGSSSRKGSISSTQDTPVVVEEDCNLASSKRLSKSNIDVSSGVEDEDPKRPLTRKQSDSSTYDCEAITQHHAFLSSIHSSVLKDEAEAPAAGTPQLSEVSLGRFDFDVSDFFLFGSPLGLVLAMRRTVLPGIDGFQMRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQRFPLGDGQSLLLADALHTHSPLFLEGSSRGSPPLLDAPASPPQAPRSQRPERRLSEGSSHSDSSESSDSLAPMGASRITAKWWGTKRIDYALYCPDVLTAFPTVALPHLFHASYWESTDVVAFILRQVMRYESASVKESTGLDPTALSPANPREKWLRKRTQVKLRNVTANHRANDVIAAEDGPQVLVGRFMYGPLDMVALTGEKVDILVMTEPSSGRWVHLDTEITNNSGRITYNVPRPRRLGVGVYPVKMVVRGDQTCAMSYLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQRVVSWLSQHNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKITAAYGSTKDISVYSVLGLPASQIFIVGRPTKKYQTQCQFLSEGYAAHLAALEASHRSRPKKNNSRMILRKGSFGLHAQPEFLRKRNHLRRTMSVQQPDPPATNPKPERAQSQPESDKDHERPLPALSWARGAPKFESVP
Protein: Protein max (Myc-associated factor X) (P52161)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Max-interacting protein 1
- Max dimerization protein 1
- N-myc protein
- Si:ch211-195d17.2 protein.
- Mitogen-activated protein kinase 14A
- Mitogen-activated protein kinase 12
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 14B
- mitogen-activated protein kinase
- Mitogen-activated protein kinase.
Sequence:
MSDNDDIEVDSDADSPRFHGVADKRAHHNALERKRRDHIKDSFHSLRDSVPALQGEKQSIKQASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKVKGTTQLQANYSSSDSSLYTNPKGQAVSAFDGGSDSSSGSEPEEQRTRKKHRPEDS
Protein: CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) (Q91X84)
Organism: Mus musculus (Mouse)
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated. Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:30611118}. Cytoplasm {ECO:0000269|PubMed:30611118}. Note=Appears to be mainly nuclear. Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). {ECO:0000250|UniProtKB:Q6UUV7, ECO:0000269|PubMed:30611118}.
Interaction partners:
- CREB-regulated transcription coactivator 2
- CREB-regulated transcription coactivator 1
- Serine/threonine-protein kinase SIK2
- Serine/threonine-protein kinase SIK1
- Cyclic AMP-responsive element-binding protein 1
Sequence:
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRNSAPEFQPSLHQADNVRGTRHHGLVERPARNRFHPLHRRSGDKPGRQFDGNAFAASYSSQHLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENDGHAEVAAFPGPLKEENLLNVPKPLPKHLWESKEIQSLSGRPRSCDVGGGNAFPHNGQNTGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTSDHLFGSMSVGNSVGNLPAAMTHLGIRTSSGLQSSRSNPSIQATLSKMALSSSLKCHPQPSVANASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSATSPLNPYPASQMVTSEQSPLSFLPTDAQAQVSPPPPYPTPQELPQPLLQQPHAQEPPTQQPQAAPSLPQSDFQLLTAQGSALTSFFPDVRFDQQPMRPSPAFPQQVPLVQQSHREPQDSFHLRPNPYSSCGSFPGTILTEDTNSNLFKGLSGGLSGMPEVSLDMDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL
Protein: Predicted gene, EG436523 (Serine protease 1 (trypsin 1) like) (Trypsinogen 12) (Q792Y9)
Organism: Mus musculus (Mouse)
Interaction partners:
- Proteinase-activated receptor 2
- Chymotrypsinogen B
- Serine protease inhibitor Kazal-type 1
- Amyloid-beta precursor protein
- Proteinase-activated receptor 1
Sequence:
MSALLFLALVGAAVAFPVDDDKIVGGYTCRENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFVNAAKIIKHPNFNRKTLNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQCLDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALADNPGVYTKVCNYVDWIQDTIAAN
Protein: Basic transcription factor 3 (AtBTF3) (Nascent polypeptide-associated complex subunit beta) (Q9SMW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL31x
- Large ribosomal subunit protein eL31z
- Nascent polypeptide-associated complex subunit alpha-like protein 5
- Nascent polypeptide-associated complex subunit alpha-like protein 4
- Nascent polypeptide-associated complex subunit alpha-like protein 1
- Nascent polypeptide-associated complex subunit alpha-like protein 3
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL23z
- Nascent polypeptide-associated complex subunit alpha-like protein 2
Sequence:
MNREKLMKMANTVRTGGKGTVRRKKKAVHKTNTTDDKRLQSTLKRIGVNSIPAIEEVNIFKDDVVIQFINPKVQASIAANTWVVSGSPQTKKLQDILPQIISQLGPDNMDNLKKLAEQFQKQASGEGNAASATIQEEDDDDVPELVGETFETAAEEKAPAAAASS
Protein: Translation elongation factor EF1A/initiation factor IF2gamma family protein (F4KI84)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPRKGLSNFDDYDDGFDDDDDAFDYDYDVDIDEHEEEAAAEPKEEIAKTQGLWRCAICTYDNVETMFVCDICGVLRHPVAGNQSINKNTAPFKFDAPSPDDLVSNGLTSSKTGPKGSGDASMRQKEKQDSVEQKPLKKGGDSSETSSRGRHDKLDDKGGAGGIKSGKSLPKAKADMSNETSSSSKYMETSESLTGTMNKMSLIGETENSSDIKIRGPKSQSKHKPEEWMLLDKESDALSQLNLAIVGHVDSGKSTLSGRLLHLLGRISQKQMHKYEKEAKLQGKGSFAYAWALDESAEERERGITMTVAVAYFNSKRHHVVLLDSPGHKDFVPNMIAGATQADAAILVIDASVGAFEAGFDNLKGQTREHARVLRGFGVEQVIVAINKMDIVGYSKERFDLIKQHVGSFLQSCRFKDSSLTWIPLSAMENQNLVAAPSDNRLSSWYQGPCLLDAVDSVKSPDRDVSKPLLMPICDAVRSTSQGQVSACGKLEAGAVRPGSKVMVMPSGDQGTIRSLERDSQACTIARAGDNVALALQGIDANQVMAGDVLCHPDFPVSVATHLELMVLVLEGATPILLGSQLEFHVHHAKEAATVVKLVAMLDPKTGQPTKKSPRCLTAKQSAMLEVSLQNPVCVETFSESRALGRVFLRSSGRTVAMGKVTRIIQDS
Protein: BZIP domain-containing protein (A7RHZ9)
Organism: Nematostella vectensis (Starlet sea anemone)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALSLTESLRYKGRLFQGFQFIASLNYRHSGARSRENHISTQPIQSFNFSFSQQQMGMSEGDSPTSPSHRSGSVIQFCSKTRDADCSSMGEKDDHSMQIESDGKPRSSRSSSKETNEYKPLDAAIKEFYSSLSASWEGYRITSCNFQPQWPTGNLPPRQSNGHSDKPTDDSECEDHEAKRGKSNHETENQAKRPRNDEKYTRAVPDKPVTKLYNLDSDHKMLQDWMVGFDQGKGCLLDIASMRAYSAQSPSLERQHGKSELKTEPHSRRPAGDPGKGSLSKAIADVKTEQYREKRRKNNASAKRSREARKMREIHAQTAAAYLQDENAKLRALVNVLKEENVYLREIMLRDASIDWKNFETTRHATPRHGQHKRHSHARIRITVWPFYDHYTVTVYEHIMCHVKYGHAVTEQTRQGKDDSMSK
Protein: Glutaminyl-tRNA synthetase 1 (A0A0U1RQE9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQQTLGSTIDKATGILLYGLASRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPEQIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPKLEADLEKKF
Protein: Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1) (P08505)
Organism: Mus musculus (Mouse)
Function: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism (Probable). Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular location: Secreted {ECO:0000269|PubMed:27893700}.
Interaction partners:
- Interleukin-6 receptor subunit alpha
- Interleukin-2
- Interleukin-6 receptor subunit beta
- Interleukin-3
- Tyrosine-protein kinase JAK2
- Tumor necrosis factor receptor superfamily member 1A
- Nuclear factor NF-kappa-B p105 subunit
- Transcription factor Jun
- Interleukin-1 beta
- Signal transducer and activator of transcription 3
Sequence:
MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT