wanglab/gogpt-training-data huggingface dataset:
Protein: Meiotic driver wtf36 (A0A482AQK7)
Organism: Schizosaccharomyces pombe (Fission yeast)
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus; the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, leading to poisoning of all progeny that do not inherit the allele.
Subcellular location: [Isoform 1]: Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. {ECO:0000250|UniProtKB:A0A218N034}.; SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm {ECO:0000250|UniProtKB:A0A218N034}. Cytoplasm {ECO:0000250|UniProtKB:A0A218N034}. Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1. {ECO:0000250|UniProtKB:A0A218N034}.
Interaction partners:
Sequence:
MKNKYYPLRSSMDEMSAKNDNEIDLEKGPLPEYNSEDGSTLPPYSDLNNPKQMGQNITKLFNWNKSTTPPDYDENRLHITDEGNNPPNTHRENHSSGTADNSSPFLIKLLISFTPIVLLNAPAVCYLKYKDAFFKNYGAAEWTLFGFWCLVCTLALIFLTYFYETWTKAVKVTVIFLAQCVKVTVIFLAKCVKVTVIFLAKCVKVTAISLAKCIKVTAIFLAQCVKVTAVGLYNSREKWVVIIWLLWVVICYTLFLRSKFGNLNLNKALICSTCSISAALLLFLLYVRLPFWTLKHMFSGLFQVLGVQSCVVIVTKGLTYLFDKHIDATGYEIEASSLFVIGNFLFFYEMECPGALKRMPKFIRNGIASFLEGIGNIGNAIGRIGNAIGRIGNAFRGANDNNDIPLGEMEVESEV
Protein: AT3g05090/T12H1_5 (Transducin/WD40 repeat-like superfamily protein) (Q93ZS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 4
- Ubiquitin carboxyl-terminal hydrolase 3
- Fanconi anemia group I-like protein
- Transducin/WD40 repeat-like superfamily protein
- Transducin/WD40 repeat-like superfamily protein
- Protein DWD HYPERSENSITIVE TO UV-B 1
- WD repeat-containing protein 76
- Cullin-4
- Protein ALTERED SEED GERMINATION 2
- Probable Ufm1-specific protease
Sequence:
MHRVGSAGSNGGSVRTRKEKKLTYVLNDANDTKHCAGINCLDVLKSSVSNDQSYLFTGSRDGTLKRWAFDEDATFCSATFESHVDWVNDAALAGESTLVSCSSDTTVKTWDGLSDGVCTRTLRQHSDYVTCLAVAAKNNNVVASGGLGGEVFIWDIEAALSPVTKPNDANEDSSSNGANGPVTSLRTVGSSNNISVQSSPSHGYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSDSMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTDLATRESVLLCTKEHPIQQLALQDNSIWVATTDSSVERWPAEVQSPKTVFQRGGSFLAGNLSFNRARVSLEGLNPAPAYKEPSITVPGTHPIVQHEILNNKRQILTKDAAGSVKLWDITRGVVVEDYGKISFEEKKEELFEMVSIPSWFTVDTRLGCLSVHLETPQCFSAEMYSADLKVSGRPEDDKINLARETLKGLLGHWLAKKKHKPKPQVLASGDTLSVKDTKKNLSASKTEESSAASDPVYPPFEFSSVSPPSIITEGSQGGPWRKKITEFTGTEDEKDFPLWCLDAVLNNRLPPRENTKLSFFLHPCEGSSVQVVTLGKLSAPRILRVHKVTNYVVEKMVLDNPLDSLAIDAASVSGGQPQPLFSGNGLLQSGLKPWQKLRPSIEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYRVAIAR
Protein: UPF0382 inner membrane protein YgdD (P0ADR2)
Organism: Escherichia coli (strain K12)
Function: May be a peptide transporter or a protein that facilitates peptide internalization.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Ribosomal RNA large subunit methyltransferase M
- Glycine cleavage system transcriptional activator
- Peptide antibiotic transporter SbmA
- Uncharacterized protein YjiL
- Sulfur acceptor protein CsdE
- Multidrug resistance protein MdtM
- Inner membrane protein YqjF
Sequence:
MTSRFMLIFAAISGFIFVALGAFGAHVLSKTMGAVEMGWIQTGLEYQAFHTLAILGLAVAMQRRISIWFYWSSVFLALGTVLFSGSLYCLALSHLRLWAFVTPVGGVSFLAGWALMLVGAIRLKRKGVSHE
Protein: Anion transporter SULP-5 (STAS domain-containing protein) (O17951)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDIPPSTPSTPTMIHVEEEEYDQLRSFYAKKRRAPMNQVEYDEKYGYQKRLKDGGKFKKRSTKVASRYYVPFTSVTNFKIFLLNLFPIFGWLPKYDWKNSLTSDVVGGITVGVLQIPQGIAYAILSRQDPIVGLYTSIYPVFLYIFFGTSKHASLGTFAVVALMTGLAVEREAFIPSDNLNSTLLPGDEALPSPIEVSCALVLGVGLIQFLMGVFRLQFLTTYLSDQLIAGFTTGSAVHVLVSQFKELFGLRGLVKHSGPGYLIRNVYDTVTNLPKANFMCCAISLATMILLHCGKEYINPIMKRKMKSNIPIPWELVAVIISTIFVALIDANELYNVKIVNKIPTGLPELSLPNPNLIPRVLPDAISIAVVVVAVHLSLSKMLAKKYEYEIDAGQELYALSFTAIGGSFFPTFPTSIGLGRTMVGVESGVKTQVATFFSCLFVLSVSLYFGRFLETLPMCVLSAIIVIALKSMLWKLRDLKGIWKLSKIDCCIWMVAFFATVLVDVSEGLLIAIFFALFTTILREQYPKWHLLANVKDTDEFSDTQQYQETIFYKGICIFKFDAPLLFHNVECFKKCIEKVYDEWKKSSEFNFVKEPNAGKGSKFTFEGMHRIAPITEIPLHPGINRDPILPRHFVIDCSGFTFIDLMGVSALKEVFSDLRKKRVQVYFASTKVPVREMFEKCSFFDFVSKENFYPTLRDATGIARLRQTEFGSLDTTSIPEFDEISNVTNNYPTQ
Protein: Mycosin-2 (EC 3.4.21.-) (MycP2 protease) (O05458)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000269|PubMed:10974545}; Single-pass membrane protein {ECO:0000255}. Note=Cell wall-associated. {ECO:0000269|PubMed:10974545}.
Interaction partners:
- ESX-2 secretion system protein eccD2
- Probable conserved membrane protein
- ESX-2 secretion system protein EccE2
- ESX-2 secretion system protein EccA2
- ESX-5 secretion system ATPase EccB5
- ESX-4 secretion system ATPase EccB4
- ESX-2 secretion system ATPase EccB2
- Tat
- ESX-5 secretion system protein EccD5
- ESX-4 secretion system protein eccD4
Sequence:
MASPLNRPGLRAAAASAALTLVALSANVPAAQAIPPPSVDPAMVPADARPGPDQPMRRSNSCSTPITVRNPDVAQLAPGFNLVNISKAWQYSTGNGVPVAVIDTGVSPNPRLPVVPGGDYIMGEDGLSDCDAHGTVVSSIIAAAPLGILPMPRAMPATAAFPPPAGPPPVTAAPAPPVEVPPPMPPPPPVTITQTVAPPPPPPEDAGAMAPSNGPPDPQTEDEPAVPPPPPGAPDGVVGVAPHATIISIRQSSRAFEPVNPSSAGPNSDEKVKAGTLDSVARAVVHAANMGAKVINISVTACLPAAAPGDQRVLGAALWYAATVKDAVIVAAAGNDGEAGCGNNPMYDPLDPSDPRDWHQVTVVSSPSWFSDYVLSVGAVDAYGAALDKSMSGPWVGVAAPGTHIMGLSPQGGGPVNAYPPSRPGEKNMPFWGTSFSAAYVSGVAALVRAKFPELTAYQVINRIVQSAHNPPAGVDNKLGYGLVDPVAALTFNIPSGDRMAPGAQSRVITPAAPPPPPDHRARNIAIGFVGAVATGVLAMAIGARLRRAR
Protein: At4g35700 (Zinc finger (C2H2 type) family protein) (Zinc finger family protein) (O81801)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Zinc finger protein ZAT2
- DNA binding protein
- Protein PLANT CADMIUM RESISTANCE 11
- C2H2 and C2HC zinc fingers superfamily protein
- C2H2-like zinc finger protein
- Protein kinase superfamily protein
- C2H2-like zinc finger protein
- Transcription factor DUO1
- Protein RALF-like 4
- Protein indeterminate-domain 11
Sequence:
MSNPEKSKIAEEENENFDESDYLWSDEEGDIREIVLGLPALRLSESLNVDESIRNEAVSAAKLIVAAAKEATGNTEQSASGTGDVSGTPEIIKVGKPRVLLEALAEASGCTPIGVTTTEGEVVKKPRKKGSTQLTHLPQGPPMCNVCGKGFASWKAVFGHLRQHKDRGYLGFLPPPTFNAAEEGFGGVATASTGGAVATAISVGEVPTASSAGGLATASSDGEGLVSSIGRARIDLNADPVEEEDKVIGVGSKRKFDLNRSPPPDGDEENDDKVE
Protein: Neuritin-like protein (Candidate plasticity gene 15-2 protein) (Q8C4W3)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MMCNCCHCHWRRRCQRLPCALTLLLLLPLAVASEGPNRCDTIYQGFAECLIRLGDGMGRGGELQTVCRSWNDFHACASRVLSGCPEEAAAVWESLQQEARRAPHPDNLHILCGAPVSVRERIAGPETNQETLRATAPALAPAPAPVLLAAALALACLLGPLA
Protein: Proline-rich protein 14 (Q9BWN1)
Organism: Homo sapiens (Human)
Function: Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit. Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha. Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2.
Subcellular location: Chromosome {ECO:0000269|PubMed:24209742}. Nucleus {ECO:0000269|PubMed:25906157}. Nucleus lamina {ECO:0000269|PubMed:24209742}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24209742}. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. {ECO:0000269|PubMed:24209742}.
Interaction partners:
- Chromobox protein homolog 5
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Chromobox protein homolog 1
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Sequence:
MDLPGDSSPPGQPRLCRQPLTRALWGARSPKRPRLQLPGAPSPLEKASRRVLAVVLEDVMAVHMVPVVPSKQTSIPQHHSYHQDPVHRQPPASPPRQAGWSSQARPPDPLCLCREPLSRIHRTSSTLRRRSRTTPGPEEGPSQKVDRAPQPTLVVMLEDIASPRPPAEGFIDETPNFIIPAQRAEPMRIVRQPTPPPGDLEPPFQPSALPADPLESPPTAPDPALELPSTPPPSSLLRPRLSPWGLAPLFRSVRSKLESFADIFLTPNKTPQPPPPSPPMKLELKIAISEAEQSGAAEGTASVSPRPPIRQWRTQDHNTPALLPKPSLGRSYSCPDLGPPGPGTCTWPPAPPQPSRPRPRRHTVGGGEMARAPPPPRPCLRKEVFPLGGVGASPSLTTSCSSTASTSFSEPAEPRLGSTKGKEPRASKDQVLSEPETKTMGKVSRFRIRRTPARPQLNLTPMGLPRPIRLNKKEFSLEEIYTNKNYQSPTTRRTFETIFEEPRERNGTLIFTSSRKLRRAVEFRDSSLPRSRRPSRGVRAAGGRTVPPNVAPSPDVGPLLQQRLEELDALLLEEETVDREQPHWT
Protein: Chemosensory protein B 93a (Q9VDA3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription initiation factor IIA subunit 2-2
- Chemosensory protein B 93b
Sequence:
MGCETSVLCTLLIFFQIIGRSFEMSHDFVPIKDDLLSKCEDKPEMGYLDAFVDLSNFSRKRGPGGVNISGNITTIWDVDPSDVVEIDVSILKFEGDKWIPTIIKGNVKDFCKSFYDKNTLYYSYSTKHVVNKKEAKEKCITTPGAILLWEPYLLKISFSYAVPLNVGRHKAVLIFTAIDKAGVKRDRDICMEIVGDIVNA
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9VBM5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein, isoform A
- CCDC113/CCDC96 coiled-coil domain-containing protein
- AT13609p
Sequence:
MCYVNRFCHYFANRYPKNFVRIVHPLSIVFVLCSTAFFFSLQMFYIAPKVFGDIAYKLYWILVTFITHNILGNMLACYMTSSSVNTLSKDSRCPNPEDEPLWHYCESCKKLRSPRSWHCVLCNTCILRRDHHCIFTGTCIGHNNQRFFFWFTFYLTLGLVTSFATFCMFILQNGGNFMSLSSVIFNLITRTFFQNYTGNTFETIAFLLNISASYMPAFMLAYQMQILSQNSTYYNIFDCTYDLGFRKNCQTIMGQRGLWTFISPLLKSPLPHDGAHWQMKQSH
Protein: Formate acetyltransferase 1 (EC 2.3.1.54) (Pyruvate formate-lyase 1) (P09373)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of pyruvate to formate and acetyl-CoA. In addition, may be involved in the control of the activity of the formate channel FocA, via direct interaction with FocA.
Subcellular location: Cytoplasm.
Interaction partners:
- Bifunctional aldehyde-alcohol dehydrogenase AdhE
- Pyruvate formate-lyase 1-activating enzyme
- Phosphate acetyltransferase
- D-lactate dehydrogenase
- Phosphate acetyltransferase EutD
- Pyruvate dehydrogenase
- Pyruvate formate-lyase 2-activating enzyme
- Putative pyruvate formate-lyase 3-activating enzyme
- Acetaldehyde dehydrogenase
- Formate channel FocA
Sequence:
MSELNEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDESFLAGATEATTTLWDKVMEGVKLENRTHAPVDFDTAVASTITSHDAGYINKQLEKIVGLQTEAPLKRALIPFGGIKMIEGSCKAYNRELDPMIKKIFTEYRKTHNQGVFDVYTPDILRCRKSGVLTGLPDAYGRGRIIGDYRRVALYGIDYLMKDKLAQFTSLQADLENGVNLEQTIRLREEIAEQHRALGQMKEMAAKYGYDISGPATNAQEAIQWTYFGYLAAVKSQNGAAMSFGRTSTFLDVYIERDLKAGKITEQEAQEMVDHLVMKLRMVRFLRTPEYDELFSGDPIWATESIGGMGLDGRTLVTKNSFRFLNTLYTMGPSPEPNMTILWSEKLPLNFKKFAAKVSIDTSSLQYENDDLMRPDFNNDDYAIACCVSPMIVGKQMQFFGARANLAKTMLYAINGGVDEKLKMQVGPKSEPIKGDVLNYDEVMERMDHFMDWLAKQYITALNIIHYMHDKYSYEASLMALHDRDVIRTMACGIAGLSVAADSLSAIKYAKVKPIRDEDGLAIDFEIEGEYPQFGNNDPRVDDLAVDLVERFMKKIQKLHTYRDAIPTQSVLTITSNVVYGKKTGNTPDGRRAGAPFGPGANPMHGRDQKGAVASLTSVAKLPFAYAKDGISYTFSIVPNALGKDDEVRKTNLAGLMDGYFHHEASIEGGQHLNVNVMNREMLLDAMENPEKYPQLTIRVSGYAVRFNSLTKEQQQDVITRTFTQSM
Protein: Epididymis secretory sperm binding protein (A0A384ME25)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADLANEEKPAIAPPVFVFQKDKGQKRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWLLRHPHPSHPAVGPCLCGEQPALCPCPGLPNYRPGTPAQLGGLLVRV
Protein: Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) (Q64131)
Organism: Mus musculus (Mouse)
Function: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (By similarity). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13761}. Cytoplasm {ECO:0000250|UniProtKB:Q13761}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000250|UniProtKB:Q13761}.
Interaction partners:
- Core-binding factor subunit beta
- T-box transcription factor TBX21
- Zinc finger homeobox protein 3
- Runt-related transcription factor 1
- Proto-oncogene tyrosine-protein kinase Src
- Catenin beta-1
- Zinc finger and BTB domain-containing protein 7B
- Nuclear receptor ROR-gamma
- Cellular tumor antigen p53
- Transforming growth factor beta-1 proprotein
Sequence:
MRIPVDPSTSRRFTPPSTAFPCGGGGGGKMGENSGALSAQATAGPGGRTRPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKIEDQTKAFPDRFGDLRMRVTPSTPSPRGSLSTTSHFSSQAQTPIQGSSDLNPFSDPRQFDRSFPTLQSLTESRFPDPRMHYPGAMSAAFPYSATPSGTSLGSLSVAGMPASSRFHHTYLPPPYPGAPQSQSGPFQANPAPYHLFYGASSGSYQFSMAAAGGGERSPTRMLTSCPSGASVSAGNLMNPSLGQADGVEADGSHSNSPTALSTPGRMDEAVWRPY
Protein: Protein spinster homolog 3 (Q6ZMD2)
Organism: Homo sapiens (Human)
Function: Sphingolipid transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Solute carrier family 22 member 1
Sequence:
MAGGMSAECPEPGPGGLQGQSPGPGRQCPPPITPTSWSLPPWRAYVAAAVLCYINLLNYMNWFIIAGVLLDIQEVFQISDNHAGLLQTVFVSCLLLSAPVFGYLGDRHSRKATMSFGILLWSGAGLSSSFISPRYSWLFFLSRGIVGTGSASYSTIAPTVLGDLFVRDQRTRVLAVFYIFIPVGSGLGYVLGSAVTMLTGNWRWALRVMPCLEAVALILLILLVPDPPRGAAETQGEGAVGGFRSSWCEDVRYLGKNWSFVWSTLGVTAMAFVTGALGFWAPKFLLEARVVHGLQPPCFQEPCSNPDSLIFGALTIMTGVIGVILGAEAARRYKKVIPGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGHILGDAGSPYLTGLISSVLRARRPDSYLQRFRSLQQSFLCCAFVIALGGGCFLLTALYLERDETRAWQPVTGTPDSNDVDSNDLERQGLLSGAGASTEEP
Protein: Sulfurtransferase (A0A384NKQ2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
Protein: Xyloglucan endotransglucosylase/hydrolase protein 22 (At-XTH22) (XTH-22) (EC 2.4.1.207) (Touch protein 4) (Q38857)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues. Its induction in case of mechanical stress, suggests that it may contribute in the adaptive changes in morphogenesis by being recruited to alter tissues tensil strength, or flexibility, enabling adaptation to mechanically stressful environments.
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Calcium-binding protein CML24
- Protein BRASSINOSTEROID INSENSITIVE 1
- Cyclin-D3-1
- Protein BRASSINAZOLE-RESISTANT 1
- Calmodulin-like protein 12
- Auxin transporter protein 1
- Steroid
- Protein EXORDIUM
Sequence:
MAITYLLPLFLSLIITSSVSANFQRDVEITWGDGRGQIKNNGELLTLSLDKSSGSGFQSKNEYLFGKVSMQMKLVPGNSAGTVTTLYLKSPGTTWDEIDFEFLGNSSGEPYTLHTNVYTQGKGDKEQQFKLWFDPTANFHTYTILWNPQRIIFTVDGTPIREFKNMESLGTLFPKNKPMRMYSSLWNADDWATRGGLVKTDWSKAPFTASYRGFQQEACVWSNGKSSCPNASKQGTTTGSWLSQELDSTAQQRMRWVQRNYMIYNYCTDAKRFPQGLPKECLAA
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (A6NJA2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
Protein: Myosin regulatory light chain 2, atrial isoform (MLC-2a) (MLC2a) (Myosin light chain 2a) (Myosin regulatory light chain 7) (Q01449)
Organism: Homo sapiens (Human)
Interaction partners:
- Myosin light chain kinase 3
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
- Rho-associated protein kinase 1
- Rho-associated protein kinase 2
- Natriuretic peptides A
- Myosin-6
- Myosin-11
- Myosin light chain 4
- Troponin T, cardiac muscle
Sequence:
MASRKAGTRGKVAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCIDQNRDGIICKADLRETYSQLGKVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTDPEEAILSAFRMFDPSGKGVVNKDEFKQLLLTQADKFSPAEVEQMFALTPMDLAGNIDYKSLCYIITHGDEKEE
Protein: Chromatin modification-related protein rik1 (Silencing protein rik1) (Q10426)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Clr4 methyltransferase complex (ClrC) which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me. ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity for the methylation of H3K9. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Rik1 is involved in the RNAi-mediated targeting of ClrC to heterochromatic repeat elements. Rik1 has also a function in meiotic telomere clustering.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18345014}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}. Chromosome {ECO:0000269|PubMed:18345014}.
Interaction partners:
- Rik1-associated factor 2
- Rik1-associated factor 1
- Cullin-4
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- RING-box protein pip1
- Cell division cycle protein cdt2
- Chromo domain-containing protein 1
- Meiotic chromosome segregation protein P8B7.28c
- Protein argonaute
- WD repeat protein iqw1
Sequence:
MALCVHSFWATAVDTATSCHFISSENCLVLLQALKINIYLCSEVHGLQFFTSIPLFSTVKHIRPYRPPGLDRDYLFVVLNDDTYFSIYWDEDYQKVIVDHPPVRYRVTFPWNRNAKSYCLVDLRMRAIFLSIDEISMICIRILSAEERLKTGRSIDSGFPFSFPVHLIYDMCILNDSSTPTLVVLHSDGLDCYVTAFLLDLSSKSLGKGIRLFERVKPSMIMPFGKRGLLVFESLFIHCMYRGNFVTINGPCTTYMHWTPLKGQKMHYIVCDTNGYLFGVYSSILGKNKWSLVMERLPIPPFDFITSLNSIHEGLLFIGSKNSESKLINLSTLKDVDSIPNLGPIHDLLVLKNDIEKSFLVCAGTPRNASLIYFQHALKLDILGQTKISGILRAMVLPSYPEHKLFLGFPSETVAFNIKEDFQLELDPSLSTKERTIALSGTNGEFVQVTSTFLCIYDSAKRSRLVYIEKITNAACYQEYSAIVINGTALAIFKKDTEVARKVFESEISCLDFSAQFQIGVGFWSKQVMILTFSDNSSISCAFQTNVPSLPRNIILEGVGVDRNLLLVSSGSGEFKSYVLFKNNLVFSETKHFGTTPVSFRRFTMNIGTYIICNNDCPHMVYGFNGALCYMPLSMPQSYDVCQFRDNSGKDFLISVSLGGLKFLQLNPLPELTPRKVLLEHVPLQAIIFQNKLLLRTLENRYEDYESYKENYHLELVDSYDDNSFRVFSFTENERCEKVLKINESSLLVGTSIIEQDKLVPVNGRLILLEFEKELQSLKVVSSMVLSAAVIDLGVYNDRYIVAFGQQVAIVKLTEERLMIDSRISLGSIVLQLIVEGNEIAIADSIGRFTIMYFDGQKFIVVARYLFGENIVKAALYEGTVYIIATNSGLLKLLRYNKDAKNFNDRFICESVYHLHDKVSKFQNFPITNTNSFLEPKMLFATEIGAIGSIVSLKDKELELEELTRKIRKLKFSYLSSMDYESIEADLISPVPFIDGDLVIDVKRWASSELFRLCRSVEHRESLNSYQKVQALLEEIQSLC
Protein: Uncharacterized fimbrial chaperone YqiH (P77616)
Organism: Escherichia coli (strain K12)
Function: Could be required for the biogenesis of a putative fimbria.
Subcellular location: Periplasm {ECO:0000250}.
Interaction partners:
- Uncharacterized outer membrane usher protein YbgQ
- Outer membrane usher protein YraJ
- Outer membrane usher protein YehB
- Probable outer membrane usher protein ElfC
- Outer membrane usher protein HtrE
- Uncharacterized outer membrane usher protein YhcD
- Outer membrane usher protein SfmD
- Outer membrane usher protein FimD
- Uncharacterized protein YqiI
- Type-1 fimbrial protein, A chain
Sequence:
MRYLNTKNIIAAGVLLSCMSSIAWGAIIPDRTRIIMNESDKGEALKLTNQSKNLPYLAQTWIEDTKGNKSRDFIVTVPPMVRLNPSEQIQIRMITQEKIAQLPKDRETLFYFNVREIPPKTDKKNVMQVTMQHALKLFWRPKAIELEDDGVMTYEKVEIIRRNDGSIRFNNKMPYHVTLGYIGTNGVTMLPQTQSLMVTPFSYANTQFKNVPSTFQVGYINDFGGLSFYEINCPVVNNICNISVANRDQ
Protein: Neurexin-1-beta (Neurexin I-beta) (P58400)
Organism: Homo sapiens (Human)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
Subcellular location: Presynaptic cell membrane {ECO:0000250|UniProtKB:P0DI97}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MYQRMLRCGAELGSPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Protein: Zinc finger protein 418 (Q8BFS8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000269|PubMed:33249983}.
Interaction partners:
Sequence:
MAALKHLAQVPRSTEKGMVCIQGCVTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSLAHWSEAEAEDKTCAPQIRTAKEGLPTKKPHPSDICSTVLKDILHLSDLPGQKPHLTEVCTDLLDQKHHRAKNWLKKDVDSLVKNCIFHVAGNPSVCSKIGEKFPAVWNLLQPKAIPKGEKQNQIKCRKAFHSEKNNSKSDKYNKSSSPQHRLHEYPRLCSGKEGFESNSCEQDLNKYSIAPSQTDQTENRPYGCHDCGKWFGQKATLRIHQRRHTGEKPYRCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEWPYECGDCGRLFRQIVSLITHQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYKCGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFKQYFYLIEHSRIHTTTEFYECGQCGKSYTQNATLIRHQRVHTGESPYKCKECGKAFEYKSRLNRHQRTHTGERPYECAKCGKFFRESYNLAEHQKIHTKAKPYNCDQCGKCFSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQLLHTGEKSYKCSK