wanglab/gogpt-training-data huggingface dataset:
Protein: GH28601p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Q9W468)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA/RNA non-specific endonuclease domain-containing protein
- Transmembrane channel-like protein
- Notopleural, isoform A
Sequence:
MMRPRCLVSFLGICLVISLGMRCDARAVNVSNTWTMPQEGLNVFYRFFRDRISWFEADAVCQFHHANLVTVDNSFQFDATRDLLRELDVNDIVWIGLMRPQNSDRFMWSNSRPLVADTGYWAESLPLMDAPLCAVIDPIRDYRWHALRCGGPETASFLCEMPVPSWADACILKDMPNLTMQYMADTASIELIRNCQEEGLLRHTCKGKEDRERAIRQLICPKERLEAQRINDITNSHFKSLQIINNIHTDNKENNDIDLLPNYGRRSGMAINIEVAPPVPPVSVPGLGELMQADAPGAVSLSGLYRIPDLVPKPVKKAAKKVITPDFAKKLQGSHQQQHNQQQQQQQQQKSRKSLVHQHEEELMMGDQPALSEEQLPPGMGMGLGIRMPLNEDDSNSDASNEIFEHLPHKKKILPQDLRTMAPIPEAKSPAMTTTTLKTTTLATPATATTTTPATTTTATAATEVVTTPKAVDTTSSQAPATTTRPTTTVRTTTITTTTTTATTTPKTEETTTTTTKKPEPTTMVAPRTTKTSAIEAAAAAAAAAAATGTTTVATSAETPTTTTSTAAAATATTTSHATPTDKSNSNNMAHPIHPSQQQHHQQQQILHEGATLQQQHATHVNESADNTRFIPPMLLVKSHYVPPAKHASEHATTTTRATTTSSTTTAAATATTPAAAAAETSTKVEVQPSTVTSSKELTAATAAATTSAATVADTVATSTVTATTGAAVEVTTSVKVTEDTAATSAATVIASEAPPAAAATTTATRAAAANEIKSNATAAAATTTAAATTTTSIPKPVREFRYPRVNQGSFKVDNNGMGSPEEEEEDEEGHLKTEAATTRHNFLEETEAPFKPNRRRSLTKPETVSYFKKILG
Protein: starch synthase (EC 2.4.1.21) (Q8GWC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MQATANLPTIWNLSLRGSSSKVHIVNPRHRKSHALHCLRSEGHEEFDNSQKSLGQSSITKEAKHKDIWNLFREAQKNIMILNKQRLAAVDELEQLKKDKEELLERINQLEAESQIVIKKDKSSLFWELLLRIDSMVINGLVNIEEASSMRKLVKEHEANISVFPLDVLQQGDAEILAELRRFTNKGKRNGLHVIHICTEMAPLVSVGPLASYITGLSCALQEEGYMVEVILPKYSTLDLDEIEGLREIEADAYSYFDGQLHANRIWNGVVSGIGVTLIQPVYYSSMFSRDKVYGYQDDFDRFAYFSRASLDYIAKSGKQPDVLHIHNWQTAIVGPLFWDVFVNQGLEGTRILLTCQDFDKGLVPPEKLELCGLDPAELHRLDRLQDNTNPHFVNILKGGVVYSNKVVIMSSSHSSIPGLEPTLAIHKDKLFFAPFGMDNSMEKDLCCDLHVSAYTSIKNL
Protein: TBC1 domain family member 7 (Q9VCC4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}.
Interaction partners:
- Gigas, isoform A
- LD23779p
- GTP-binding protein Rheb homolog
- RAC serine/threonine-protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Mitogen-activated protein kinase ERK-A
- Putative glycogen synthase kinase-3 homolog
- Protein kinase shaggy
Sequence:
MNTDERNFRSIYYEKCQINSVEEQKSLNKLLQDDIRNLSKLKQFCMNYTVPNNNRSYLWALVMGILPLHKASTAYVRDQRREMYEDLRRAVTVLRFTDHKQKEQPFMWLIDHKKKAQVMHTMWLIESNRLWHGNTSASLQADDMHFIEIVRTLLQIFDDNVETYWIAKGFYKYTRELKKECVKLKEQTQNILKREDLSLLNHLELLGLFDGNSTLLDNWYITCFAGIICTTHLVKIWDKVCGGSRKIVVFLFVELVKDIRSSILKQTSLADVKRLIETVKDLDGVIIVNKAIKSLQNNSSEVEYTH
Protein: Zinc finger protein 281 (Q99LI5)
Organism: Mus musculus (Mouse)
Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein NANOG
- Nuclear receptor subfamily 0 group B member 1
- Steroid hormone receptor ERR2
- Nucleus accumbens-associated protein 1
- POU domain, class 5, transcription factor 1
Sequence:
MKIGSGFLSGGGGPSSSGGSGSGGSSGSASGGSGGGRRAEMEPTFPQSMVMFNHRLPPVTSFTRPAGTAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQPSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSLLHQHAQQQPAQHHRDVLLSSGSRTDEHGNQEPKQDANVKKAKRPKPESQGIKAKRKPSASSKPLVGEGEGAVLSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEAIAKGAASAEPGSSNHNSMGNLAVLSQGNTSSSRRKSKSKSIAIENKEHKTGKTNESQMSNNINMQSYSVEMPTVSTSGSIIGTGIDELQKRVPKLIFKKGSRKNADKSYLNFVSPLPDVVGQKSLSGKPGGSLGIVSNNSVETISLLQSTSGKQGPISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSGKSETQKEDPFNLTEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKTSMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR
Protein: General transcription factor IIIC subunit 5 (General transcription factor IIIC, polypeptide 5, 63kDa, isoform CRA_c) (Q5T7U1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAEAADLGLGAAVPVELRRERRMVCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQKGVLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYLAVHTEAGGKHTSMYDKVLMLRPEKEAFFHQELPLYIPPPIFSRLDAPVDYFYRPETQHREGYNNPPISGENLIGLSRARRPHNAIFVNFEDEEVPKHLWIRFGYDPRKNPDAKIYQVLDFRIRCGMKHGYAPSDLPVKAKRSTYNYSLPITVKKTSSQLVTMHDLKQGLGPSGTSGARKPASSKYKLKVSLQTLRDSVYIFREGALPPYRQMFYQLCDLNVEELQKIIHRNDGAENSCTERDGWCLPKTSDELRDTMSLMIRQTIRSKRPALFSSSAKADGGKEQLTYESGEDEEDEEEEEEEEEDFKPSDGSENEMETEILDYV
Protein: Biofilm regulator BssR (P0AAY1)
Organism: Escherichia coli (strain K12)
Function: Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway.
Interaction partners:
- Biofilm regulator BssS
Sequence:
MFVDRQRIDLLNRLIDARVDLAAYVQLRKAKGYMSVSESNHLRDNFFKLNRELHDKSLRLNLHLDQEEWSALHHAEEALATAAVCLMSGHHDCPTVITVNADKLENCLMSLTLSIQSLQKHAMLEKA
Protein: Protein GOLVEN 3 (Root meristem growth factor 4) (AtRGF4) [Cleaved into: GLV3p] (Q9LI64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Signaling peptide (root growth factor) required during root gravitropism in a PIN2-traffic dependent manner, thus influencing the formation of auxin gradients. Maintains the postembryonic root stem cell niche.
Subcellular location: [GLV3p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
Interaction partners:
- Protein GOLVEN 9
- Protein GOLVEN 10
- Protein GOLVEN 1
- Protein GOLVEN 7
- Protein GOLVEN 5
- CLAVATA3/ESR
- Protein GOLVEN 6
- Protein GOLVEN 11
- Protein GOLVEN 2
- CLAVATA3/ESR
Sequence:
MMRFTIIVIAFLLIIQSLEEEHILVYAHEGGEAGHKSLDYQGDQDSSTLHPKELFDAPRKVRFGRTTRAEKEQVTAMNNDSWSFKISGEHKQTNILADHDTTKNTFCKKMMIIVNDLTSLPTLEPSTSTNDMEKLARLLRDDYPIYSKPRRKPPVNNRAPDKF
Protein: Probable protein-L-isoaspartate O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) (Q9URZ1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MFWSFNLSSNAALVQHLVESKFLTNQRAIKAMNATSRSFYCPLSPYMDSPQSIGYGVTISAPHMHATALQELEPVLQPGCSALDIGSGSGYLVAAMARMVAPNGTVKGIEHIPQLVETSKKNLLKDINHDEVLMEMYKEKRLQINVGDGRMGTSEDEKFDAIHVGASASELPQKLVDQLKSPGKILIPIGTYSQNIYLIEKNEQGKISKRTLFPVRYVPLTDSPDDSSDY
Protein: Melanocortin receptor 4 (MC4-R) (P32245)
Organism: Homo sapiens (Human)
Function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Subcellular location: Cell membrane {ECO:0000269|PubMed:25163632}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Pro-opiomelanocortin
- Agouti-related protein
- Leptin
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Guanine nucleotide-binding protein G
- Transmembrane protein 18
- Pro-neuropeptide Y
- BTB/POZ domain-containing protein KCTD15
- Appetite-regulating hormone
- Leptin receptor
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Protein: Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) (P27773)
Organism: Mus musculus (Mouse)
Function: Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (By similarity). Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Association with calcitriol does not affect its enzymatic activity (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:P30101}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P11598}. Melanosome {ECO:0000250|UniProtKB:P30101}.
Interaction partners:
- Calreticulin
- Tapasin
- Calnexin
- Calreticulin
- Beta-2-microglobulin
- Endoplasmic reticulum chaperone BiP
- Endoplasmin
- Antigen peptide transporter 2
- Antigen peptide transporter 1
- Protein disulfide-isomerase A6
Sequence:
MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL
Protein: Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) (Q7LFX5)
Organism: Homo sapiens (Human)
Function: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305|PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
Interaction partners:
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Carbohydrate sulfotransferase 13
- Carbohydrate sulfotransferase 7
- Carbohydrate sulfotransferase 12
- Carbohydrate sulfotransferase 14
- Carbohydrate sulfotransferase 3
- Carbohydrate sulfotransferase 11
Sequence:
MRHCINCCIQLLPDGAHKQQVNCQGGPHHGHQACPTCKGENKILFRVDSKQMNLLAVLEVRTEGNENWGGFLRFKKGKRCSLVFGLIIMTLVMASYILSGAHQELLISSPFHYGGFPSNPSLMDSENPSDTKEHHHQSSVNNISYMKDYPSIKLIINSITTRIEFTTRQLPDLEDLKKQELHMFSVIPNKFLPNSKSPCWYEEFSGQNTTDPYLTNSYVLYSKRFRSTFDALRKAFWGHLAHAHGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLHPEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQASSAKEQSKMNTIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPNARLIVMLRDPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPVRLQVGLYAVYLLDWLSVFDKQQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEALMTKSPASNARRPEDRNLGPMWPITQKILRDFYRPFNARLAQVLADEAFAWKTT
Protein: Response regulator receiver (Q2YRH9)
Organism: Brucella abortus (strain 2308)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- histidine kinase
- Cell-division control histidine kinase PdhS
- histidine kinase
- PAS domain:GGDEF:PAS-associated C-terminal domain:PAC motif:EAL domain
- Blue-light-activated histidine kinase
- histidine kinase
- diguanylate cyclase
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
- histidine kinase
Sequence:
MTLSTRIAPHLPYLRRFSRALTGSQSSGDAYVAAALEALIADVGIFPEASSDRIGLYRLFCNLYKNASIRMPETSSEFAWETHAARNLAHIAPLPRQAFLLVAVEGFNDHEAAEILEVDQAEFGRLLSTASGEISRQVATRLMIIEDEPLIAMDIEQMVESLGHEVVGIARTKDEALALYEKEKPRMVLADIQLADGSSGIDAVNEILHDNTIPVIFITAFPERLLTGERPEPTFLVTKPFNPDMVKALISQALFFEEASQVAA
Protein: Paired box protein Pax-8 (Q06710)
Organism: Homo sapiens (Human)
Function: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Subcellular location: Nucleus.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma
- Homeobox protein Nkx-2.1
- Forkhead box protein E1
- Thyroglobulin
- Protein kinase C beta type
- Thyrotropin receptor
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Protein kinase C alpha type
Sequence:
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL
Protein: Uncharacterized protein RclB (Reactive chlorine resistance protein B) (P75687)
Organism: Escherichia coli (strain K12)
Function: Probably involved in reactive chlorine species (RCS) stress resistance.
Subcellular location: Periplasm {ECO:0000305}.
Interaction partners:
- Inner membrane protein RclC
- Probable pyridine nucleotide-disulfide oxidoreductase RclA
- RCS-specific HTH-type transcriptional activator RclR
- Uncharacterized protein YjfY
- Uncharacterized protein McbA
Sequence:
MFKKSVLFATLLSGVMAFSTNADDKIILKHISVSSVSASPTVLEDTIADIARKYNASSWKVTSMRIDNNSTATAVLYK
Protein: Anion exchange protein (M9PF01)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Membrane {ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362035}.
Interaction partners:
Sequence:
MAEKNEYIELPWTMNSSSGDDEAPKDPRTGGEDFTQQFTENDFEVTPPAQRVQFILGEDVDDGTHVSHPLFSEMGMLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDMEAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSSKTDTSTHLGAIGVTTWFHAGASPQHQAQNHAQNQGRPQSQAIPKDMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPELPKEEVDEEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLGVPTQKLEVPNELKPTLSTRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRELKILDDIMPEMTKRAAADDLHKLDAEVGLLARIFPWGKGSRSRVVTKPPGLDDGIVGSGGAVGAGLITCTTSNANEKEFEAQSSLLKK
Protein: Nuclear protein (T24D18.18 protein) (Q9S9M7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Dem-like protein
- Phospholipase A1-IIdelta
- Uveal autoantigen with coiled-coil/ankyrin
- Photosynthetic NDH subunit of subcomplex B 2, chloroplastic
- Dehydrodolichyl diphosphate synthase 2
- Acyl-CoA N-acyltransferases
- Peptidyl-prolyl cis-trans isomerase CYP19-1
- GCN5-related N-acetyltransferase 10, chloroplastic
- Kunitz trypsin inhibitor 2
- Pyridoxal 5'-phosphate synthase subunit PDX1.3
Sequence:
MAKASSTLFAVSCSASARFSFLRRSESLKPSVSRARFAVPMAMAAASAATAKKLAPAVIVGGGRVGRALQEMGNGEDLLVKRGEAVPVDFEGPILVCTRNDDLDAVLEATPQSRWKDLVFFQNGMMEPWFESKGLGDTDQVLAYFAVSKLGEPPVDGKTDTNPEGLTAAYGKWASEIAARLQSGGLSCKVLDKEAFQKQMLEKLIWICAFMLVGARHPGASVGTVEKEYRDEVSRLIQELAAAAAAEKGLTFEENMVERLCAYSRAVSHFPTAVKEFKWRNGWFYSLSEKAIAEGQPDPCPLHTEWLKELKVI
Protein: EF-hand domain-containing protein 1 (Myoclonin-1) (Q5JVL4)
Organism: Homo sapiens (Human)
Function: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D9T8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22926142}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19734894, ECO:0000269|PubMed:22926142}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28370826}.
Interaction partners:
- Parkin coregulated gene protein
- Membrane progestin receptor beta
- Chloride channel protein 2
- Enkurin
- Cilia- and flagella-associated protein 52
- Cilia- and flagella-associated protein 45
- Tektin-1
- EF-hand domain-containing family member B
- WD repeat-containing protein 90
- Cilia- and flagella-associated protein 20
Sequence:
MVSNPVHGLPFLPGTSFKDSTKTAFHRSQTLSYRNGYAIVRRPTVGIGGDRLQFNQLSQAELDELASKAPVLTYGQPKQAPPADFIPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQVNIYYYLEDDSMSVIEPVVENSGILQGKLIKRQRLAKNDRGDHYHWKDLNRGINITIYGKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQPLRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLLMNRQRVPKVLVENAKNFPQCVLEISDQEVLEWYTAKDFIVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITDLPRIDVSKREPPPVKQELPPYNGFGLVEDSAQNCFALIPKAPKKDVIKMLVNDNKVLRYLAVLESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTVDNPVYYGPSDFFIGAVIEVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRKREAPAPEAESKQTEKDPGVQELEALIDTIQKQLKDHSCKDNIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYNFVRAFSN
Protein: Pro-thyrotropin-releasing hormone (Pro-TRH) (Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone (TRH) (Protirelin) (TSH-releasing factor) (Thyroliberin) (Thyrotropin-releasing factor) (TRF)] (P20396)
Organism: Homo sapiens (Human)
Function: As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.
Subcellular location: Secreted.
Interaction partners:
- Thyrotropin-releasing hormone receptor
- Prolactin
- Thyrotropin-releasing hormone-degrading ectoenzyme
- Thyrotropin subunit beta
- Pyroglutamyl-peptidase 1
- Neurotensin/neuromedin N
- Pro-opiomelanocortin
- Progonadoliberin-1
- Corticoliberin
- Somatoliberin
Sequence:
MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDDFLRQVERLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEEEEEEGGAVGPHKRQHPGRREDEASWSVDVTQHKRQHPGRRSPWLAYAVPKRQHPGRRLADPKAQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQGAYGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPLEE
Protein: Rqc2 homolog RqcH (RqcH) (Ribosome-associated protein quality control protein H) (O34693)
Organism: Bacillus subtilis (strain 168)
Function: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. Selectively binds tRNA(Ala)(UGC), which is presumably the sole source of tRNA(Ala) used for Ala tailing directed by this protein. May add between 1 and at least 8 Ala residues; detection of the Ala tail requires either deletion of clpP or its inhibition. Binds to 50S ribosomal subunits, at least 30% of which contain a P-site tRNA and thus are obstructed.
Interaction partners:
- RQC P-site tRNA stabilizing factor
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL22
Sequence:
MSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAKGKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIMIFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLPGQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAGLANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELLDRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELLTANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVVEEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNPVLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQTIMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTVIKLKKS
Protein: Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) (Q90955)
Organism: Gallus gallus (Chicken)
Function: Molecular chaperone.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
Interaction partners:
- Heat shock cognate protein HSP 90-beta
- Prostaglandin E synthase 2
- Uncharacterized protein.
- Prostaglandin E synthase
- Heat shock protein HSP 90-alpha
- Lipocln_cytosolic_FA-bd_dom domain-containing protein
- peptidylprolyl isomerase
- Uncharacterized protein
- peptidylprolyl isomerase
- Stress induced phosphoprotein 1.
Sequence:
VFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFNNIDPNESKHKRTDRSILCCLRKGESGQAWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDDDVDLPEVDGADDDSPDSDDEKMPDLE
Protein: Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6) (G2XKQ0)
Organism: Homo sapiens (Human)
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs.
Subcellular location: Nucleus {ECO:0000269|PubMed:27211601}. Note=Forms prominent non-membrane-bound structures in the nucleus. {ECO:0000269|PubMed:27211601}.
Interaction partners:
Sequence:
MSDLEAKPSTEHLGDKIKDEDIKLRVIGQDSSEIHFKVKMTTPLKKLKKSYCQRQGVPVNSLRFLFEGQRIADNHTPEELGMEEEDVIEVYQEQIGGHSTV