wanglab/gogpt-training-data huggingface dataset:
Protein: Armadillo repeat-containing protein 2 (Q8NEN0)
Organism: Homo sapiens (Human)
Function: Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).
Interaction partners:
- Cilia- and flagella-associated protein 43
- Sperm flagellar protein 2
- Cilia- and flagella-associated protein 70
Sequence:
MLSPNDKMLGKLDPFYQPSVSKQKTSAEIISEARNALRTVRTQRPFTPQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVPASPTREEDSCFSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVESKETVMMGDSMVKINGIYLTKSNAICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPSHLKNGGDQGKRHARASSCPSSSDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPILRELEKEENIETVCAACTQLHHALEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLKLAKIILALKVSRKNLLNVCKLIFKISRNEKNDSLIQNDSILESLLEVLRSEDLQTNMEAFLYCMGSIKFISGNLGFLNEMISKGAVEILINLIKQINENIKKCGTFLPNSGHLLVQVTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYKGDKDVCTNIARIFSKLTSYRDCCTALASYSRCYALFLNLINKYQKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKPVAQQLLNRIQRHHTFLEPLPIPSF
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q7KTC7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
Sequence:
MADDTSSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQVLSKYLSGLALAIGGLHCSMNVFNKLLNTGLKWPMELFDTTPLGRILSRYSKDVDTVDSVLPAITVQLLNTCFGVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV
Protein: NADP-dependent oxidoreductase domain-containing protein (Q2UHY1)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- L-fuconate dehydratase
- Dihydrodipicolinate synthase/N-acetylneuraminate lyase
Sequence:
MSLGKKVTLNSGAEIPTLGFGTWQSAPGEVGEAVYQALKAGYRHLDLATIYQNQKEIAVGIKRAFEEFNIKREDVFITSKLWNSQHHPDVVEKALDDCLAECGLDYLDLYLVHWPVAFKTGNEYFPLVEGSTVPGGDCIIDDSISIVDTWKAMTKLPKSKARAIGVSNHMVEHLEAIINATGVVPAANQIERHPVLQSPKLIQYCKEKGIHVTAYSAFGNNMIGEPLLITRPEIKAVAEEAGKRLGKEVSPAQVILAWSQVGGHSVIPKSVTPARIAANFQEIELTPEEIAKVTALGTERRYNVPYVANKPRWNINVFGEPEEAPADHKVIL
Protein: Homeodomain protein (Q9YHB7)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
VDAVQTLPLKPPFYDNSDNPYTRWLASAEGIQYSLHGLAAGAGGPEAGSKSPEPSADESPDNEKEAAGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEKEHLASLIRLTPTQVKIWFQNHRYKMKRAPKKGMEVNPLPSPRRVAVPVLLRDGKPCHTLKAQDLAAATFQTGIPFSAYSAHSLQHMQYNAHYSAAGSPHYPTAHHLVQAQQWTW
Protein: Cyclin-dependent kinase inhibitor CIP1 (CDK1-interacting protein 1) (Q02606)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:28676626}. Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:28676626}. Note=Localizes to the nucleus upon osmotic stress. {ECO:0000269|PubMed:28676626}.
Interaction partners:
- G1/S-specific cyclin CLN2
- Cyclin-dependent kinase 1
- G1/S-specific cyclin CLN3
Sequence:
MLLERLHKRLHAGSSRRSQENKDKNCKPEDALPIQPEAQHQTQDPQPLLNCDYDDMIAFDRNLSTPVFTPVMTPINNSSSNQAKSSDASYFPPYLNANRTRQNSASSLASSVSDFAQNFKQHTFYNNNAQFTSFTPQFVGLLLEVYQNTCSDPTITPFDTTNPPSGILNRVAKAAIQQSELQQLDIGCDRNSWLLTLVRQRLLQEVRKDGYLSRNTSLTSLPPPPPPQFSEMLRVPSPFVNADITDPIPLSNTNSNPNVSSTTSLTNTLNWYSLQRSNVSMKNRNGSSQYISELQPQPILARTNSNNSVSNSNAFSLLTPTPTTDSAFNFNIALLSRQRSNIISSPLASTRLPTANVSTEESSILPNESLKLKRDLLRLKR
Protein: Phosphoinositide phosphatase SAC7 (AtSAC7) (EC 3.1.3.-) (Protein ROOT HAIR DEFECTIVE 4) (Protein SUPPRESSOR OF ACTIN 1C) (AtSAC1c) (Protein SUPPRESSOR OF ACTIN 7) (SAC domain protein 7) (SAC1-like protein AtSAC1c) (Q9C5G5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphoinositide phosphatase that preferentially hydrolyzes PtdIns(4)P. Regulates the accumulation of PtdIns(4)P on membrane compartments at the tips of growing root hairs leading to proper root hair development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12713536}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18281508}; Multi-pass membrane protein {ECO:0000255}. Note=Associated to tip-localized membranes in growing root hairs (PubMed:18281508). {ECO:0000269|PubMed:18281508}.
Interaction partners:
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
- Phosphatidylinositol 4-kinase beta 2
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C
- Phosphatidylinositol 4-kinase alpha 2
- Phosphatidylinositol 4-kinase alpha 1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B
- Phosphatidylinositol 3-kinase VPS34
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
Sequence:
METVDSRNKLHSRLRLWEFPDQYIIEPADGSGSSCLDISRVDASMKLIDQVPESNSVRVPKIRSIFGVVGMLKLLAGSYLVVVTESERVGSFLGHPIFKVTTLKVLPCDHSLKNSPEEQKKMETEFSKLLSVAEKTTGLYFSYEVNLTLSSQRLHEMGDESKSLPLWRQAEPRFLWNNYMLEVLIDNKLDQFLLPVIQGSFNSFETAIGRDIVDITLIARRCTRRNGTRMWRRGADLDGYVANFVETEQIVQMNGYTSSFVQVRGSMPFMWEQVVDLTYKPKFEIVQPEEAKRIAERHFLDLRKKYGSVLAVDLVNKQGGEGRLCEKYATVMQHITGDDIRYLHFDFHQICGHIHFERLSILYEQIEGFLEKNGYFLLNEKGEKMKEQLGVVRSNCIDCLDRTNVTQSMIGRKMLEVQLKRIGVFGAEETISSHLNFDEHYKILWANHGDEISIQYSGTPALKGDFVRYGHRTAHGVLKDGWSSLRRYYLNNFADGTKQDAIDLLQGHYIVAVSRDMAPVPQKGGLEAVANFPVALFVVLMSFWFATMSLKQTGSDYKHKHLFFSLLWTGICVGMAALVRANGRIFCNRPRLHKPRG
Protein: Cathelicidin-derived antimicrobial peptide 2 isoform A (Q08G22)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKALVRSLLLLAVANLLVRGQTQTETRYEDIITAASNQLLPMEEQAFHPLLNQLEVETLNTEDVDQSEVSVRLSFPLQETLCSKAQGQRGQPCPLKKNGKRMMCSMEVRHPILEIGNTLNTDRSDISCEYMEAEVQKIRTRRGKDSGGPKMGRKDSKGCWRGRPGSGSRPGFGSGIAGASGVNHVGTLPASNSTTHPLDNCKISPQ
Protein: S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) (P10768)
Organism: Homo sapiens (Human)
Function: Serine hydrolase involved in the detoxification of formaldehyde.
Subcellular location: Cytoplasm. Cytoplasmic vesicle.
Interaction partners:
- Alcohol dehydrogenase class-3
- Carboxylesterase 5A
- Lactoylglutathione lyase
- Alcohol dehydrogenase 6
- All-trans-retinol dehydrogenase [NAD
- Sorbitol dehydrogenase
- Alcohol dehydrogenase 1A
- Cocaine esterase
- All-trans-retinol dehydrogenase [NAD
- Alcohol dehydrogenase 1C
Sequence:
MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
Protein: Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) (Q549C5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
Sequence:
MAAAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPSLPGKI
Protein: Protein arginine methyltransferase 2 (A1L1Q4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MIESESRDCNEGEEYVGLVDFVAEGDEQLSFSVGDRLLVHDRSSDVWWWAEMQGHFGYVPSSYLHQRTEDMEDAWQDDEYFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCALLAKPAGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLPTKVDVLVSEWMGNCLLFEYMLESVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQKVEFWENPYGLNFSYLQSLAQKEFLSKPKFSHHLQPEDCLSTPADVITLDMVTIQVSDLERLKGEFTFTVEKSGMFHGFTVWFSAHFQCLEEDGPSIELNTGPYSEITHWKQTLFMLDAPVSVEEGDIIAGSIRLQRNPIWRRHLSITFLWNINSTEVSTVKTKCFPMWR
Protein: AAA ATPase, putative (Q385D4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- FACT complex subunit
Sequence:
MVVTRSQTKLSAQLHTGDAGPHTTNANKFSNFITNAPQTPPREEPLGRGCRIPRPAAPTYDSLYVSEALTRRSKQPAVQELQINTRYPERDAAKRAVTKLSDTLELLDGSGAGPSESSDDSDGNDRCAMHTDGTPTRKVPHGRFRCNGTPGKVVTRKRDRDESVDSSITDESLRRGSPEEEAGGLLFEHSSLDLSSEEPLSDCEVQRAKKNAKVCVSKNKPINHYLSAEIKETSLEDKKGLFGASRGSRQRRTEDVLLGLSGADDAAHRREPGLSKEGNNNALGDITPLNLDTSVTFEKVGGLSGHIVLLREMVLLPLMYPGMLQAMSLSPPRGVLFVGPPGTGKTLMARALANEGMLHANQKITFFMRKGADILSKWVGEAERQLILLFEEAKRQQPSIIFFDELDGLVPVRHAKAEQSQAALVATLLALIDGLDDRGRVVVIGATNRPDTIDPALRRPGRFDRELYFPLPDGAARRHILDIVTKPMLPADRLDREEILQELTDRCAGWTGAEIQAVCTEAGLNRLRTALPQIYTTSKKLQIPEGALIVQREDFFIAAHRVKNSARRVTTAVGDGLDEHLEHLLNSTRCKLLSFVAARWPSASTALAKEKRDCSNSADAVRELSSFPISNVAHPFLLFLTTEAVGCATDREDSEFAVQKAAIALTKGLPSIRAFTLYLPHLVVDRDASGLLGVRTTGDLGPLSGNLTCGEGGDDLRDSNRFDTGHIYSCIAAVRRCSGPSLVILKGLEEWLADHAPEVDASFGCGNKCGIGRSNDVDNLCYYLNCLRDTDALIIAPTVRRDVSSTFFAGNRLSIQLRTAVCEVPCTPSDDDLRRFLSYLLRVVDLALKTSAPINLQELPEDLSPPPPLSPKQVRAAWLDEVDLWRRVDFRRRQLRHVLTKWVGQYINNKKFSVFVSRNLDLTPTHDLYNHWQQHTNGRQISLSDVMMKLENEEYTSLSQYNNDIDMLVNNVRSFFRTVSAFDLRYRVRASELKELTVLNLYKINRAVVSFCEKHKDLVMPGAPPPCSTADKALQEPPKTPQRGTTGATPTQRKKPRYYGMRRRRRPANRGGRSCQKKAPVENVERDQPREAEIDVLGSSGSRDDNHDREEKARRKTENMEVEVKKMVEEEMVEVDGAPVDESIPRRLEVELPQQCDIAGLAPEDGEGTEHAAEHHSPDGTYGSADEWMGVMLLKLRGFSFLRLHLVMQAAMRLLESEVQMRRVRGEHQQTTEFEPASSSREVSPFKSSMTFCSWMLLKAVQEVEVVSSNG
Protein: t-SNARE affecting a late Golgi compartment protein 1 (Syntaxin tlg1) (Q9HGN3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Probably shuttling between TGN and early/late endosome. {ECO:0000250}.
Interaction partners:
- Vesicle transport v-SNARE protein vti1
- Synaptobrevin homolog 1
- Integral membrane protein sed5
- t-SNARE affecting a late Golgi compartment protein 2
- Protein transport protein sec22
- Syntaxin pep12
- Synaptobrevin homolog ykt6
- Protein transport protein gos1
- Syntaxin-like protein fsv1
- Vacuolar protein sorting-associated protein 45
Sequence:
MEDPFYEVKADASNQMEQVRKLYNSFMAARNSGVLSPNTELTYAIDELSETLKDLKAAVEIAMKNSEHFGLDEEELKSRRRFVSELDIELNNIQLKMGAAPSTPVSTEPYTVDNGASAGLSEEDHAVNRQYQEQLYQQQDVMLDGVYDTIGNIRGQAALMGEELGQQADLLDTLDNSIETTNSKLRRGMKRLKDFTIASADSKSGCCITVLIIILIALLVLVIVL
Protein: Ras-related protein Rab-40A-like (Ras-like GTPase) (P0C0E4)
Organism: Homo sapiens (Human)
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:22581972}. Mitochondrion {ECO:0000269|PubMed:12145744, ECO:0000269|PubMed:22581972}.
Interaction partners:
- FYVE and coiled-coil domain-containing protein 1
- Ras-related protein Rab-40A
- Ras-related protein Rab-40B
- Elongin-C
- Cullin-5
- Rab-3A-interacting protein
- Guanine nucleotide exchange factor MSS4
- Serine/threonine-protein kinase ULK1
- PSME3-interacting protein
Sequence:
MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGTAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRLNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPIALRSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKRSSLCKVKIVCPPQSPPKNCTRNSCKIS
Protein: Uncharacterized protein (Q584F3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIHICNPTEERCRMDLIFPEEAHTVTVRHFSVPEPPGAPELRQQSNFPITSNPQISPAPDPVVVAAIQRRIECGSGLSSCGESGDSMDNASDPARRLAHLQSALSILCHTAAMDKSQFFLYRKQVSKKSTNDNAECASTTDYSITDIYTTVRALKLEYDEAVKHSRDEKGTQTANAEVLELARRRTECRVDDCLRLLEPTITELILDFTHVKKVPVAYTEEMLQGLPQVFAMERWPCTILRKETDDFVGQKRPRVSSRPLAGESGRGESFFEHNDVAHAATAVVFKALRDLRKNDYMCLLGDKTLTSAPKAADVSRSHLTYGELVERTLSGVYRERGLLAALYDVKRLLYGAYDAAPAEHAPTIKSLHAQFEQDLRRHYSAFLSKTGLRCRANDFVLQVKTMFDINPLPASREVKDGEGGVPLYSETQKKCLKLLGHLRAVDSKGWFEYPAFDLANIELSSIERWICGPPFSTKTDREAFVALRDVLEQMVDNCVLSYGPTSQYSRVITMVRQRLVEASQEVGLL
Protein: NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (NAD-dependent protein delactylase sirtuin-3) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) (Q9NTG7)
Organism: Homo sapiens (Human)
Function: NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
Interaction partners:
- Acetyl-coenzyme A synthetase 2-like, mitochondrial
- Forkhead box protein O3
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- Nicotinamide phosphoribosyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Histone H3-7
- Histone H3.3
- Histone H3.1t
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
Protein: IgE-dependent histamine-releasing factor, putative (Q57TT7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GST N-terminal domain-containing protein
- 60S acidic ribosomal protein P0
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S8
- 60S ribosomal subunit protein L31, putative
- Translation elongation factor 1-beta, putative
- Translation elongation factor 1-beta, putative
- Translation elongation factor 1-beta, putative
- 40S ribosomal protein S15, putative
- 40S ribosomal protein S4
Sequence:
MKIFRDILTNAEVVCDNDKPMDVLDEIVYAVQGRYIEIGGEDYGISANADEDAAEGAAGDVADEKQRVIDVVHNNRYTETNYDKNSYMAHIRGYMKQLLEKIEDEGAKKAFQTNAAAFVKKVIKEIDEYQFFIPEGNEEDPDNGMIVLCKWDGETPTFYFWKDGLKGERV
Protein: Isonitrile hydratase (EC 4.2.1.103) (Cyclohexyl-isocyanide hydratase) (Q8G9F9)
Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
Function: Catalyzes the hydration of cyclohexyl isocyanide to N-cyclohexylformamide. Acts on various isonitriles, but not on nitriles or amides. Probably involved in detoxification.
Interaction partners:
Sequence:
MALQIGFLLFPQVQQLDLTGPYDVLASLPDVQVHLVWKDLVPVTSSTGLQLKPTTTFEDCPVLDVICVPGGAGVGPLMEDEQTLDFIRSQAAQARYVTSVCTGSLVLGAAGLLQGKRATTHWAYHDLLPTLGAIPVKDRVVRDGNLFTGGGITAGIDFALTLAQELVGVDTAQLVQLQLEYAPAPPFDSGSPDTAPSAVVDEARKRAAPSLKLRTEITERAAAKLNLR
Protein: N(4)-bis(aminopropyl)spermidine synthase (EC 2.5.1.128) (Branched-chain polyamine synthase A) (Q5JIZ3)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. Can also use spermine to produce N(4)-aminopropylspermine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01947, ECO:0000269|PubMed:24610711}.
Interaction partners:
- S-adenosylmethionine synthase
- Flagellin B2
- Xaa-Pro dipeptidase
Sequence:
MREIIERVKEKTTIPVYERTIENVLSAIQASGDVWRIVDLSEEPLPLVVAVVTALYELGYVAFENNQVILTRKGKELVEKYGIGPRADYTCSHCQGRTVEIDAFSELLEQFKEITRDRPEPAHQFDQAYVTPETTVARVALMHSRGDLENKEVFVLGDDDLTSVALMLSGLPKRIAVLDIDERLTKFIEKAADEIGYENIEIFTFDLRKPLPDYALHKFDTFITDPPETVEAIRAFVGRGIATLKGPGCAGYFGITRRESSLDKWREIQRVLLNEFGVVITDIIRNFNEYVNWGYVEETRAWRLLPIKVKPSYNWYKSYMFRIQTLEGSKGFEDEITVGQELYDDEESSTT
Protein: Diencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1) (Q8NFW5)
Organism: Homo sapiens (Human)
Function: Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O35137, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
Sequence:
MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLRLRAKQHAASLGLDTLPN
Protein: RNA polymerase-associated protein RTF1 (P53064)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of SPT15, the TATA box-binding protein, and the relative activities of different TATA elements.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15643076}.
Interaction partners:
- FACT complex subunit POB3
- FACT complex subunit SPT16
- RNA polymerase-associated protein LEO1
- RNA polymerase-associated protein CTR9
- Transcription elongation factor SPT5
- RNA polymerase II-associated protein 1
- Cell division control protein 73
- Transcription elongation factor SPT4
- Transcription elongation factor SPT6
- Antiviral protein SKI8
Sequence:
MSDLDEDLLALAGADESEEEDQVLTTTSAKRAKNNDQSLSKKRRIEVGSVEDDDEEDDYNPYSVGNADYGSEEEEEANPFPLEGKYKDESDREHLESLPEMERETLLFERSQIMQKYQERKLFRARGRDMKEQQQRAKNDEDSRKTRASTRSTHATGHSDIKASKLSQLKKQRARKNRHYSDNEDEDDEEDYREEDYKDDEGSEYGDDEEYNPFDRRDTYDKREEVEWAEEEDEQDREPEISDFNKLRIGRSFVAKFCFYPGFEDAVKGCYGRVNVGTDKRTGKTSYRMVRIERVFLQKPYNMGKFYTNQYFGVTQGKDRKVFQMNYFSDGLFAEDEYQRYLRALDNSQMIKPSLHSLSNKTKEVMDFVNTPLTDKTTDEVVRHRMQFNKKLSGTNAVLEKTVLREKLQYAKETNNEKDIAKYSAQLRNFEKRMSVYEKHHENDQSDIKKLGELTSKNRKLNMSNIRNAEHVKKEDSNNFDSKSDPFSRLKTRTKVYYQEIQKEENAKAKEIAQQEKLQEDKDAKDKREKELLVAQFRRLGGLERMVGELDIKFDLKF
Protein: Autonomous glycyl radical cofactor (P68066)
Organism: Escherichia coli (strain K12)
Function: Acts as a radical domain for damaged PFL and possibly other radical proteins.
Interaction partners:
- Pyruvate formate-lyase 1-activating enzyme
- Pyruvate formate-lyase 2-activating enzyme
- Putative pyruvate formate-lyase 3-activating enzyme
- UPF0304 protein YfbU
- Putative electron transfer flavoprotein subunit YgcR
- Putative glycyl-radical enzyme activating enzyme YjjW
- Probable dehydratase PflD
Sequence:
MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKAGYAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
Protein: Chitin synthase 3 complex protein CSI2 (Q08054)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Appears to be a structural component of the chitin synthase 3 complex.
Interaction partners:
Sequence:
MRLPEISIWKVILLLHLFALQEFQLVSAANLPSLSSSTKAADSSSKGSSSAKTTTSLGKSSVTSKDVSSSHNVTSSTKMPKITTSASTSLYTNSSLWSNNSVISTSSITPSSVYIPVTDGNKFLYQAHHPNGTVFIAFAGCLGAILLSLTGAWIALNIKSWRSARKENKLRNLENQYQHDPFYFQTNINDDESETSSHSDDSDISEKVLKNNSSRMSLYTLGSTSVLNLLNNKTDANDNFRSSMFISPTEILQSDANNSNTWSQSNESAIYDSLSSTPREPGATQILGKFTDSTNPFNYTSYNLSPDSEDRSTPKSNVSQGKVKKYRPPSVHLDQLLDGKE
Protein: Catalase (EC 1.11.1.6) (P04040)
Organism: Homo sapiens (Human)
Function: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Subcellular location: Peroxisome matrix {ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:8769411}.
Interaction partners:
- Peroxisomal multifunctional enzyme type 2
- Sterol carrier protein 2
- 2-Hydroxyacid oxidase 2
- 2-Hydroxyacid oxidase 1
- Superoxide dismutase
- Kynureninase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Superoxide dismutase, mitochondrial
- Extracellular superoxide dismutase
- Superoxide dismutase
Sequence:
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL