wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-binding cassette sub-family C member Sur (Sulfonylurea receptor) (Dsur) (Q9VL32)
Organism: Drosophila melanogaster (Fruit fly)
Function: May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Inwardly rectifying potassium channel 2, isoform D
- Inwardly rectifying potassium channel 1, isoform F
- Inwardly rectifying potassium channel 3, isoform D
Sequence:
MKQLFNIIHCDHLNGHVRSIYDNLNTDICGIDRVRRVFTFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKGASKW
Protein: Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (P51569)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
Subcellular location: Lysosome.
Interaction partners:
- Beta-galactosidase
- Galactocerebrosidase
- Beta-hexosaminidase subunit alpha
- Neutral alpha-glucosidase C
- Arylsulfatase A
- Lactosylceramide 4-alpha-galactosyltransferase
- Beta-hexosaminidase subunit beta
- Lysosomal alpha-glucosidase
- 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
- Galactosylceramide sulfotransferase
Sequence:
MKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRFPSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGSFGSYDIDAQTFADWGVDLLKFDGCHCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNKDVIAINQDPLGKQGYCFRKENHIEVWERPLSNLAWAVAVRNLQEIGGPCPYTIQISSLGRGLACNPGCIITQLLPEKVHLGFYEWTLTLKTRVNPSGTVLFRLER
Protein: Secretory leukocyte peptidase inhibitor (A0A096MJ68)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Elastase, neutrophil expressed
Sequence:
MRLQDAIKIGACPARKPAQCLKREKPECGTDWECPGKQRCCQDTCGFKCLNPVPIRGPVKKKPGRCLKFQGKCLMLNPPNKCQNDGQCDGKYKCCEGMCGKVCLPPV
Protein: WHAMM and JMY related, isoform A (WHAMM and JMY related, isoform C) (Q9VH71)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQVSSDVFAHPPPAVRPPPHYADNVSINASLDGMKSSSSSNSLDRYLGAPPSVALAGPSFATSVLVSSKGSKYEISGPVNFQHVSGDVTRDRTRNAFDLNADPNDKVLRKYMMERGITEADISDMRRQEVIKKIIHSNFTWMPPKSDLQAQPKVQDHARPLLYATISTNNQITPPPSPPPPPIATISRPTEAPNFSNYASLTSRFVDISDMDLPAPTPAAPTPFQPAEVGSVIPVQVQPQQSVKPKVPPPPSAVMAKNTHGYPAAIDIRQVRPSVAPKVANETYATISPQRKVGSMRVPPPAPPKPTIVPHTNSTISNGSLYAVSPVQYAPVAKPAPPAAPAKPTSRSSAVYMTPLSAQKTQISSTPVPVSPPPPTAASVGVPPPPPAPPAGVPPAPPPMPVFGAGGAPPPPPPPSSGMAGVPPPPPMQKSQPKAVSAASTGGDPRDAFLESIRQGVKLKKVDQKAATISGIKPRPERKPVTTDFLSELKLGITLRRVKNPADNPYSEESESQA
Protein: Fibroblast growth factor 1 (FGF-1) (Acidic eye-derived growth factor II) (EDGF II) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) (Prostatropin) [Cleaved into: Endothelial cell growth factor beta; Endothelial cell growth factor alpha] (P03968)
Organism: Bos taurus (Bovine)
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity).
Subcellular location: Secreted. Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity). {ECO:0000250}.
Interaction partners:
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor
- Protein S100-A13
- Fibroblast growth factor 2
- Insulin-like growth factor 1
- Fibroblast growth factor
- Fibroblast growth factor-binding protein 1
- Fibroblast growth factor
Sequence:
MAEGETTTFTALTEKFNLPLGNYKKPKLLYCSNGGYFLRILPDGTVDGTKDRSDQHIQLQLCAESIGEVYIKSTETGQFLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKHWFVGLKKNGRSKLGPRTHFGQKAILFLPLPVSSD
Protein: Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) (Q9D1Q6)
Organism: Mus musculus (Mouse)
Function: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:15652484}.
Interaction partners:
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- ERO1-like protein alpha
- DnaJ homolog subfamily B member 11
- Peroxiredoxin-4
- Protein ERGIC-53
- ERO1-like protein beta
- Endoplasmic reticulum chaperone BiP
- Protein RER1
- Calreticulin
- Calreticulin
Sequence:
MNPAVFLSLADLRCSLLLLVTSIFTPITAEIASLDSENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEYPDKNQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSNPVHEIQSLDEVTNLDRSKRNIIGYFEQKDSENYRVFERVASILHDDCAFLSAFGDLSKPERYNGDNVIYKPPGRSAPDMVYLGSMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKDDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQDQDVASSPPESSFQKLAPSEYRYTLLRDRDEL
Protein: Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase eta) (DGK-eta) (Q64398)
Organism: Mesocricetus auratus (Golden hamster)
Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth (By similarity). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86XP1}. Cell membrane {ECO:0000250|UniProtKB:Q86XP1}. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. {ECO:0000250|UniProtKB:Q86XP1}.
Interaction partners:
- Lysophospholipid acyltransferase 1 isoform X1
- Lysophospholipid acyltransferase 2 isoform X1
- Phosphatidate cytidylyltransferase
- diacylglycerol kinase
- Phospholipase
- Phosphoinositide phospholipase C
- Phosphatidate cytidylyltransferase
- Phosphoinositide phospholipase C
- Acyltransferase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Sequence:
MAGAGYQHHPPGGAAVGTSAVSPTAAGPGEDSSDSEAEQGGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQSREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKAMVHTACKDLYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPAKASLLPEPPEASGGFYMTIYEDSVANHLTKILNSDEHAVVISSAKILCETVKDFVAKVEKAQDKTLENTVVAEAVANKCSVLNEKLEQLLQALHADAQASRVPPGVGPAIPEEDAVESSSEESLGESKDQLVNDIAKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDEQTVQPCEPVSPSCDYDSPEADDSKDNDTKESPAAKSTSQAPEAQAIRGHFQTDSVAGSAMATTKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTNLYIHPAADLATEEVSQMRLCSQAAEELITRICDAATIHCLLGAGTGSSVNACSHALNKANPRFPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSSALHSVEVELQKLTEIPWLYYILRPNEDEEPPMDCTKRNSKSTVFRIVPKFKMEKAQKQKTSSQPGPGDTESGSYEANSPGN
Protein: Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12) (Q8IYM2)
Organism: Homo sapiens (Human)
Function: Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. May play a role in cell differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:35104454}. Cytoplasm, cytosol {ECO:0000269|PubMed:35104454}.
Interaction partners:
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Sequence:
MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGYVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKGSLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT
Protein: Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Q9WVH9)
Organism: Mus musculus (Mouse)
Function: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9UBX5}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14745449}. Note=co-localizes with ELN in elastic fibers. {ECO:0000250|UniProtKB:Q9UBX5}.
Interaction partners:
- Elastin
- Lysyl oxidase homolog 1
- Fibrillin-1
- Protein-lysine 6-oxidase
- Fibronectin
- Lysyl oxidase homolog 3
- Lysyl oxidase homolog 2
- Microfibrillar-associated protein 2
- Latent-transforming growth factor beta-binding protein 2
- Microfibrillar-associated protein 5
Sequence:
MPGLKRILTVTILALWLPHPGNAQQQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYSGPYPAAAPPVPASNYPTISRPLVCRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECETENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECVNQPGSYFCSCPPGYVLLDDNRSCQDINECEHRNHTCTSLQTCYNLQGGFKCIDPISCEEPYLLIGENRCMCPAEHTSCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
Protein: Transcription factor MYB90 (Myb-related protein 90) (AtMYB90) (Production of anthocyanin pigment 2 protein) (Q9ZTC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of phenylpropanoid-derived compounds such as anthocyanins.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TT8
- Transcription factor GLABRA 3
- Transcription factor EGL1
- Protein TRANSPARENT TESTA GLABRA 1
- Dihydroflavonol 4-reductase
- Leucoanthocyanidin dioxygenase
- Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Flavonoid 3'-monooxygenase
- Chalcone synthase
Sequence:
MEGSSKGLRKGAWTAEEDSLLRLCIDKYGEGKWHQVPLRAGLNRCRKSCRLRWLNYLKPSIKRGRLSNDEVDLLLRLHKLLGNRWSLIAGRLPGRTANDVKNYWNTHLSKKHESSCCKSKMKKKNIISPPTTPVQKIGVFKPRPRSFSVNNGCSHLNGLPEVDLIPSCLGLKKNNVCENSITCNKDDEKDDFVNNLMNGDNMWLENLLGENQEADAIVPEATTAEHGATLAFDVEQLWSLFDGETVELD
Protein: Hemoglobin cathodic subunit alpha (Hemoglobin cathodic alpha chain) (B3EWR7)
Organism: Ophisurus serpens (Serpent eel) (Muraena serpens)
Function: Involved in oxygen transport from the gills to various peripheral tissues.
Interaction partners:
Sequence:
SLSDKDKTFVKAFWGKLKGKADDVGAEALARMFGAFPATKSYFAHWPDLSAGSGPVKKHGKIIMAGVGDAVDKIDNLVSGLSKLSDLHATKLRIDXXXXXXXXXXXLVTLAANFPADFTPELHVSLDKFFAAVGAALSDKYR
Protein: Protein NSP-INTERACTING KINASE 3 (EC 2.7.11.1) (LRR receptor-like serine/threonine-protein kinase NIK3) (Q93ZS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in defense response to geminivirus infection.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15489295}; Single-pass type I membrane protein {ECO:0000269|PubMed:15489295}.
Interaction partners:
- LRR receptor-like Serine/Threonine-kinase
- L10-interacting MYB domain-containing protein
- Nematode resistance protein-like HSPRO1
- Ternary complex factor MIP1 leucine-zipper protein
- Putative RRM-containing protein family protein)
- Protein OXIDATIVE STRESS 3 LIKE 3
Sequence:
MEGVRFVVWRLGFLVFVWFFDISSATLSPTGVNYEVTALVAVKNELNDPYKVLENWDVNSVDPCSWRMVSCTDGYVSSLDLPSQSLSGTLSPRIGNLTYLQSVVLQNNAITGPIPETIGRLEKLQSLDLSNNSFTGEIPASLGELKNLNYLRLNNNSLIGTCPESLSKIEGLTLVDISYNNLSGSLPKVSARTFKVIGNALICGPKAVSNCSAVPEPLTLPQDGPDESGTRTNGHHVALAFAASFSAAFFVFFTSGMFLWWRYRRNKQIFFDVNEQYDPEVSLGHLKRYTFKELRSATNHFNSKNILGRGGYGIVYKGHLNDGTLVAVKRLKDCNIAGGEVQFQTEVETISLALHRNLLRLRGFCSSNQERILVYPYMPNGSVASRLKDNIRGEPALDWSRRKKIAVGTARGLVYLHEQCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLLDHRDSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQKALDFGRSAHQKGVMLDWVKKLHQEGKLKQLIDKDLNDKFDRVELEEIVQVALLCTQFNPSHRPKMSEVMKMLEGDGLAERWEATQNGTGEHQPPPLPPGMVSSSPRVRYYSDYIQESSLVVEAIELSGPR
Protein: NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 3) (NADH-plastoquinone oxidoreductase subunit 3) (P0C321)
Organism: Oryza sativa subsp. indica (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01394}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01394}.
Interaction partners:
- 4Fe-4S ferredoxin-type domain-containing protein
- Uncharacterized protein
- 4Fe-4S His
- NADH:ubiquinone reductase
- Plus3 domain-containing protein
- Photosystem I iron-sulfur center
- NADH-quinone oxidoreductase subunit L
- NADH dehydrogenase flavoprotein 2
- NAD
- NAD
Sequence:
MFLLHEYDIFWAFLIIASLIPILAFWISALLAPVREGPEKLSSYESGIEPMGGAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGISVFIEAFIFVLILVVGLVYAWRKGALEWS
Protein: Protein kinase, putative (Q38BL0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTSTTEFTGSSLLQDEKVVLKDYVASQRLGEGGYASVFLVKYVPSGECFAMKIIPNNYLMGSESLIIQEATVMQSLEHPHVVKLYKFLQSTSAFYLIMELAECGELFDLVIAEKYFREATARLYFQQLMSAIDYCHSNGVAHRDLKAENLLLGKDNRLLVCDFGFCSKYRTEGEDGDDGSPNETLQPIGTLHYTSPEMVTRTTGSLAVDVFQQDLWCAGIILFFMLTGRLPFSGRDDEETLHLIQMGSFSFTEEEEARLTPGARSLVRGMLALEPTERPSISQILESEWFVVDIKADLFPHRPELKRGAAFLDFSTQHRATEQEEAAIRKAFKKINIDGYGDITRDQLRDMLTTLHGKKVSAEGVSELVHLFTGKKDSMFVTFKQFHDAWVIRDLAHSSFKHSDDFQLPKIIDTEMDGVERKVVRQVRTAFDCVDELHTGVIDMNQLKRLFERCQTDVNDEEIRSLIRFFDEHEVGNRGEITFRMFLKGVVSRDMLVRHPMGRKLAAATNLAALYRYCELRESVRRGVFVSGVWDNIVKKLMKHADRLVLIRDVVNMSDVERVYSFCYVGKSAAQTTPLTMSATPPAIESEGCFLTPKDLSHNALLGSSFCTSSIPMLPHSTGHAGQYSNVNDAHHGNLASSYEESSRWAESLKAGSVSPPQRTIAYGSGPTPKNQVTGTCTIDVLLSSGAFEYTLVRFCRISGRTHDFHEAVAYVAKLLEPERLRAMEDTLPRGESVLI
Protein: Cation/proton antiporter, putative (Q7D5V5)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGNGGILGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPDSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFLGIGLSVDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN
Protein: Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen) (Q9Y215)
Organism: Homo sapiens (Human)
Function: Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
Subcellular location: Synapse.
Interaction partners:
- Acetylcholinesterase
- Muscle, skeletal receptor tyrosine-protein kinase
- Cholinesterase
- Protein Dok-7
- 43 kDa receptor-associated protein of the synapse
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Acetylcholine receptor subunit epsilon
- Agrin
- Proline-rich membrane anchor 1
- Acetylcholine receptor subunit beta
Sequence:
MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT
Protein: Annexin A10 (Annexin-10) (Q9QZ10)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFCGEYVQGTIFPAPNFNPMMDAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGLMYPPPSYDAHELWHAMKGPGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQANREEGYSDPAMAAQDAMVLWEACQQKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAIVRCIQDKPSYFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAICAGDVEDY
Protein: SD01586p (Q95TI5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLTSSSPNGSRHGAMSINTPPSTPSISSSTPASTSIYCYLCGLHSDLTLARVLYASKEGSRPYFPLLLKHNSLPNAEQLRNNSALVCTFCYHSMLNQWRKYEAQSPSVNPADRKYNWHDYNCHLCGITTYRKRVRALPVNEFPFVKHQKSDDGLLLENGEYAVVCLDCYESLRQQASQHDRFGVPISRRAYNWVPQPPPPEDSPESAVARLPCGERSDRIHINNALRPVPGKKTTSPKQYDKSKEVPPKAGQKRPATSPAPHIPVPHHLQTPPGGGAGGLPGSSVANSPIPSSAGGNALMNHALPNNHIGTPSPQQQHQHQQHQQQQQQQQHQAQQQAQQQAVAAAVQQQLAAGVGLPPGAIGAASASSRGSFAAALRTLAKQADIKEEDVGGDRSVPTSGAGGPPPSSSGPGSLNSVAGRVGSERPGEDRVSSNKKRSPPSPQPPEKIARLSHTPQTASLQPELLARSGFQPYRSDERLMHPAGAFPLEAYSHFAGLPGIPPAFLNPAGLPYTEQLYLEHRYQLFRAAGAHPSHPHAAALYPQMASPYSHLYSMMPGAALGISPAMHDRMKLEEEHRARLAREEEREREIQREKERELREQREKEQREKEQREKEQREREQREKEQREKEARERKLRDEERERERERQQLLTASHHYSNQLYSPLNRNLLGSMIPHLNMSLRGPPGALHGLPGMSHYHAAAANAQRQSPHGAMGLNLGMAGLPGVPPLGGHGPNLQHHLQQAAMGLAHPGAAGLTHPGFSAAALGLGAHPHSLNLSHPHMSPHHPASLAHQLPPHTSSAGGGGLSNSIPVTASSSLSASSPHTSLNLTSSVKLSADQVPTSTPSGGVSGSGMPPTTSSSHIPNMGHYYHHGHLAAMHAAAAAASGMTPTAAHQQQPLSLPSSPKITPPITPSSSANGGRAGGSPHAMRHHIAAAVAAAAQQSAMIDKAATPVTHEPTTLDLTGSNSNSSNQAPSNASSGQPTNHEVNGAESNGASQTESKEHLAIKEDGHKSSPPPVALEKKPATPNAAADKPIHPDSSPENSSRRSASPQSDANNSLPAVSVTAAASGKCKEETPKILDSDTTATTKTDIEEEKQRARLSVSPTPTAPKIMVASPDTVSTSGGVTSTTSGTTPPPVVSSSTSSAGKAPALTSDEVSTSAATSAAEPTR
Protein: Protein kinase C (EC 2.7.11.13) (Q4JG04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPVSNGSMMDLPSEYVKIKAHYGGDMLISDLDLALTYTEVCKEVREMCGVRKETPITLKWIDDEGDPCTISSQMELEEAFRIYSRSRHSGLLLHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGLGRQGYKCINCKLLVHKRCHKLVPLTCQRHMDPVMPSQEPLVDDDKSGEEVELPPEDPEDTDAIPVPFLAHNRKVEKAEDDSEDLKAVVDGIEGIQISQCLGLGDFDLIRVIGRGSYAKVLLVRLKKNEQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSTEETV
Protein: S-gicerin (Q90989)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAGGRRAAPRCGWGWGGGWGCCPFLCLLLCCGAAGRPEVYMPSSAGSGDREHSQAGVQLLHPWECLLHLRRVVLCQPRPLRSGEAVRHHASGVRIDETEYSERLSVGEDKALSISKVTRQDNARTFICQVGADSQGVGESRTELYTYKIPAPPEITPNSAGIPAQSNDMLKIAQCTSENSFPSPNITWYKNGEPLLQEEDKTKILTTLVRESNGLYTVVSTLFSKVTREDRNSLFHCTVHYWLQGQMRTKDSPRVNVTVFYPTEHVELRVATNAGIVKEGDDVKLVCDADGNPAPVFSFFRRELGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQTLDLDDMTQHEGDVELVVNYIEGVQVKMEPSSPLHEGDSVRLSCTAHSPVKLDYQWRDARGRKVAEGNQLLLTNLTFETSSNFSCRVKARSVPGLEQSKQVAVAVKGKPRIVAISAPLYVRQDEVINLTCKAIAFPQPSFHWSVNGTTHEYMENQHMASNLTVRVSHDLLRAGAMCRVSNALGVSEKHIQLLDQKPSESKGIIIVAIIVCILVVAVLGSIIYFLHKKGKISCGRSGKQDIARNTSI