wanglab/gogpt-training-data huggingface dataset:
Protein: Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) (Q9CZX7)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:29378918}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8N4L2}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29378918}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:29378918}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Inositol polyphosphate 5-phosphatase OCRL
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Myotubularin
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Synaptojanin-1
Sequence:
MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPGTSGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA
Protein: Leucine-rich repeat protein kinase family protein (Leucine-rich repeat receptor-like protein kinase) (Putative receptor-like protein kinase; 33719-31696) (Q9C9E4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- NAC domain containing protein 50
- NAC domain containing protein 52
- Lysine-specific demethylase JMJ14
Sequence:
MAVAWLIWPIVLSLTALSANSITESESLLKFKKSLNNTKSLDSWTPESEPCGASQRWIGLLCNKNSVFGLQIEQMGLSGKVDVAPLKDLPSLRTISIMNNSFSGDIPEFNRLTALKSLYISGNRFSGNIPSDYFETMVSLKKAWLSNNHFSGLIPISLATTLPNLIELRLENNQFIGSIPNFTQTTLAIVDLSNNQLTGEIPPGLLKFDAKTFAGNSGLCGAKLSTPCPQPKNSTASITIEGTMKDANKSKYFLAFSTLGVLLIVVLVSLAFRKKKKKRRRKKARRTSEQDNSDDQQIQVTVEGSNSSRQSRSSRSGELNKGVAGTSDLVMVNKEKGVFRLSDLMKAAAHVLGNPGGGSNRPRSSGGVGSAYKAVLSNGVTVVVKRVTVMNQVSVDVFDKEIRKLGSLQHKNVLTPLAYHFRQDEKLLVFEFVPNLNLLHRLHGDHEEFQLDWPSRLKIIQGIARGMWYLHRELGFLNLPHGNLKSSNIFLAEDGEPLISEFGLQKLINPDAQSQSLVAFKSPEADRDGTVSAKSDVFSFGVVVLEILTGKFPSQYAGLNRAGGANLVEWLGSALEQGGWMDLLHPMVVTAAAEDKIMEEEIENVLRIGVRCTREDPDQRPNMTEVVDELTIEDSNDDFITIET
Protein: Auxin-responsive protein IAA9 (Indoleacetic acid-induced protein 9) (Q6K846)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ubiquitin-related modifier 1 homolog
- Auxin response factor 11
- Ubiquitin-like protein ATG12
- Autophagy-related protein 3.
- Os10g0560450 protein
- Os02g0517366 protein
- Auxin response factor 7
- Molybdopterin synthase catalytic subunit
- Os01g0694200 protein.
- Auxin response factor 9
Sequence:
MELELGLAPPNSGHLVVDELSSSSSSGGGSGSAPVSASSAGKRGFREAFQETLLLFDDGSCCNTSDDDCRRRKKTVVGWPPVSSARRACGGANYVKVKKEGDAIGRKVDLALHSSYDELAATLARMFPTNDHQGEKKMANDDHGDAAGPVVTYEDGDGDWMLVGDVPWDDFARSVKRLKILG
Protein: tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) (O42912)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Deaminates adenosine-37 to inosine in tRNA-Ala.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C1734.10c
- SUMO-conjugating enzyme ubc9
- 18S rRNA aminocarboxypropyltransferase
Sequence:
MEEFTLDRNSNVGNLIALAVLNKFDELARHGKPIIRANGVREWTTLAGVVIQKKMENEFICVCLATGVKCTPAGIIKNEQLGSVLHDCHAEILALRCFNRLLLEHCILIKESKKDTWLLEVADNGKFTLNSNLLIHLYVSECPCGDASMELLASRLENNKPWNLTVDSEKLMRGRADFGLLGIVRTKPGRPDAPVSWSKSCTDKLAAKQYLSILNSQTSLICEPIYLSCVVLYKKVIVKSAIDRAFGPFGRCAPLAEFGEKDNPYYFHPFTVLETDENFLYSRPLNQAEKTATSTNVLIWIGDKMQCTQVIHNGIKAGTKAKDVEKSQTLICRKSMMNLLHQLSQSLTNEKNYYEWKKLNIKRCQQKQILRNILKNWIPNGGNEFQWI
Protein: Small ribosomal subunit protein bS18c (30S ribosomal protein S18, chloroplastic) (P56807)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS19c
- Small ribosomal subunit protein uS11c
- Small ribosomal subunit protein bS16cz
- Large ribosomal subunit protein bL36c
- At1g64880
- Large ribosomal subunit protein bL20c
- Small ribosomal subunit protein mS29
- Ribosomal protein S7.
Sequence:
MNKSKRLFTKSKRSFRRRLPPIQSGDRIDYRNMSLISRFISEQGKILSRRVNRVTLKQQRLITIAIKQARILSLLPFLNNQKQFERSESTPRTTSLRTRKK
Protein: Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (D4-GDP-dissociation inhibitor) (D4-GDI) (Ly-GDI) (Rho-GDI beta) (Q9TU03)
Organism: Bos taurus (Bovine)
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10802295}.
Interaction partners:
- Transforming protein RhoA
- Tumor necrosis factor receptor superfamily member 16
- Ras-related C3 botulinum toxin substrate 1
- Cell division control protein 42 homolog
- Ras-related C3 botulinum toxin substrate 2
- Rho GDP-dissociation inhibitor 1
- cAMP-dependent protein kinase catalytic subunit alpha
- Ras-related C3 botulinum toxin substrate 1.
- cAMP-dependent protein kinase catalytic subunit beta
- Rho-related GTP-binding protein RhoH
Sequence:
MTEKAPEPHVEEDDDELDGKLNYKPPPQKSLKELQEMDKDDESLTKYKKTLLGDGPVVADPTAPNVTVTRLTLVCESAPGPITMDLTGDLEALKKETFVLKEGVEYRVKINFKVNKDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPIEEAPKGMLARGTYHNKSFFTDDDKHDHLTWEWNLSIKKDWTE
Protein: Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67) (Q14994)
Organism: Homo sapiens (Human)
Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.
Interaction partners:
- Nuclear receptor coactivator 1
- Retinoic acid receptor RXR-alpha
- Mediator of RNA polymerase II transcription subunit 1
- Cytochrome P450 3A4)
- Nuclear receptor coactivator 2
- Nuclear receptor subfamily 0 group B member 2
- Cytochrome P450 2B6
- Cytochrome P450 7A1
- Solute carrier family 53 member 1
- Cytochrome P450 3A7
Sequence:
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
Protein: NAC domain-containing protein 105 (ANAC105) (Protein VASCULAR RELATED NAC-DOMAIN 3) (Q9FH59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9C8W9, ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- Uncharacterized protein
- At1g01310 superfamily protein)
- CAP superfamily protein
- CAP superfamily protein
- Small ribosomal subunit protein uS19y
Sequence:
MMKVDQDYSCSIPPGFRFHPTDEELVGYYLKKKIASQRIDLDVIREIDLYKIEPWDLQERCRIGYEEQTEWYFFSHRDKKYPTGTRTNRATVAGFWKATGRDKAVYLNSKLIGMRKTLVFYRGRAPNGQKSDWIIHEYYSLESHQNSPPQEEGWVVCRAFKKRTTIPTKRRQLWDPNCLFYDDATLLEPLDKRARHNPDFTATPFKQELLSEASHVQDGDFGSMYLQCIDDDQFSQLPQLESPSLPSEITPHSTTFSENSSRKDDMSSEKRITDWRYLDKFVASQFLMSGED
Protein: Claudin-1 (O88551)
Organism: Mus musculus (Mouse)
Function: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:10508613, ECO:0000269|PubMed:10562289, ECO:0000269|PubMed:9647647}. Cell membrane {ECO:0000269|PubMed:11889141}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:O95832}. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000250|UniProtKB:O95832}.
Interaction partners:
- Occludin
- Tight junction protein 1
- CD81 antigen
- Tight junction protein 2
- Tight junction protein ZO-3
- Junctional adhesion molecule A
- Scavenger receptor class B member 1
- Claudin-5
- InaD-like protein
- Cadherin-1
Sequence:
MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYEFGQALFTGWAAASLCLLGGVLLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV
Protein: Syndecan 4-B (Syndecan-4.2) (xSyn4.2) (Q1AGV6)
Organism: Xenopus laevis (African clawed frog)
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates non-canonical Wnt signaling, being necessary and sufficient for fibronectrin-mediated translocation of dvl2/dsh to the plasma membrane. Required for proper convergent extension movements during gastrulation, which shape the neural plate, and for subsequent neural tube closure.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNRLLLLLALVLSGVAAESIRETETMDPTSMLEYESSGSFTDEVFVDEDDDDDYEDGVDYEIDSESDNDEDYSGSGDDDFDDEDNVEDEDEEETTTLGNQIPEHDFDETKTGRKFDTFNENNEIDNDIRHPAKPKTLEPSNEIPMASIGSSGFFQRTEVIVAIIAGTLVGLVVAVSFIVFLVIRRNQNGDLVKKPIYKKTSTMEV
Protein: Major biofilm matrix component (Spore coat-associated protein N) (Translocation-dependent antimicrobial spore component) (P54507)
Organism: Bacillus subtilis (strain 168)
Function: TasA is the major protein component of the biofilm extracellular matrix. It forms amyloid fibers that bind cells together in the biofilm. Exhibits an antibacterial activity against a variety of Gram-positive and Gram-negative bacteria. In laboratory strains, is also involved in proper spore coat assembly.
Subcellular location: Secreted {ECO:0000269|PubMed:10049401, ECO:0000269|PubMed:10368135, ECO:0000269|PubMed:10658653, ECO:0000269|PubMed:16430696}. Forespore intermembrane space {ECO:0000269|PubMed:10049401, ECO:0000269|PubMed:10368135}. Note=In undomesticated strains, is secreted and primarily associated with the extracellular matrix (PubMed:16430696). In laboratory strains, is secreted into the medium early in sporulation and is also incorporated into the spore. Processing, export and incorporation into spores depend on SipW (PubMed:10049401). {ECO:0000269|PubMed:10049401, ECO:0000269|PubMed:16430696}.
Interaction partners:
- Signal peptidase I W
- TasA anchoring/assembly protein
- Uncharacterized protein YveK
- Sporulation cortex protein CoxA
- Putative pyridoxal phosphate-dependent aminotransferase EpsN
Sequence:
MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTLDLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSPEDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPKFLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQGNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN
Protein: Transcriptional regulatory protein RcsB (Q8GM84)
Organism: Klebsiella pneumoniae
Interaction partners:
Sequence:
MNTMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPDLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISASGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVSLSATDKE
Protein: 40S ribosomal protein S19 (Q8IFP2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 60S ribosomal protein L27
- 40S ribosomal protein S23, putative
- Small ribosomal subunit protein eS30
- 40S ribosomal protein S15
- 60S ribosomal protein L13
- 60S ribosomal protein L35ae, putative
- 40S ribosomal protein S6
- 60S ribosomal protein L6, putative
- 60S ribosomal protein L26, putative
- 40S ribosomal protein S27
Sequence:
MAEQFTEDIGVVNKRLLEPVPFVKTNNCIKDVDADLFIRSYATHLKLHNKITYPKWCTFVKTGKGRKLAPLNEDWYFIRASSILRRLYLHPDIGVGFLRRQFSSKQRRGVAPNHTSLASGKILRSILQQLENLGYVEQNPKKKGRRLTTKGENAINNFARYINKKVYNKE
Protein: Glycosyltransferase family 2 protein (WbcL protein (EC 2.4.1.212)) (Q56915)
Organism: Yersinia enterocolitica
Interaction partners:
Sequence:
MISVTVFTPTFNRAHVLKRCYLSILEQDRDDIEWLIVDDGSTDNTAEVVDSFKIENKLNIKYIYQDNSGKQAAWNKAVENASGEYFIGLDSDDAFIAGSINKLLSMNAVFDDKEIIGIRAISVSSETLKPNNYYLSNEDKKSSWFDEFSSGIRGERIDFFKTELLRKYLYPVASGINFIPEIWFYSTVAKEYCFYYSSIPVRIFFDDDKNNRLSKSSIKKNAIGHYISRKALLENMPKTIWLYRPVDFIKSVLRLNQTLTMIDNKYIDHSKSSFLVKIVALPSIIINKIKRR
Protein: Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1) (P49326)
Organism: Homo sapiens (Human)
Function: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity).
Subcellular location: Microsome membrane {ECO:0000305|PubMed:20947616}. Endoplasmic reticulum membrane.
Interaction partners:
- Cytochrome P450 3A4)
- Cytochrome P450 2D6
- Cytochrome P450 2C9
- Gap junction alpha-5 protein
- Lysophosphatidic acid phosphatase type 6
Sequence:
MTKKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRALSQHPTLNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDAVIFATGYSFDFPFLEDSVKVVKNKISLYKKVFPPNLERPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDKRYVESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSMTSTMTIGKFMLALAFFAIIIAYF
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (A0A2R8YF80)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKKITGKDIHDTASSVARGLQFQRGLQFCTRASKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED
Protein: Pachytene checkpoint protein 2 homolog (Protein CENTRAL REGION COMPONENT 1) (Q7XK25)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Plays a key role in chromosome recombination during meiosis. Required for the initiation of meiotic recombination and the recruitment of PAIR2 onto meiotic chromosomes. Essential for meiotic DNA double-strand break (DSB) formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:23943860}. Chromosome {ECO:0000269|PubMed:23943860}. Note=Appears as punctuate foci on chromosomes at leptotene. Colocalizes with ZEP1 to the central region of the synaptonemal complex. {ECO:0000269|PubMed:23943860}.
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Exonuclease 1
- Origin of replication complex subunit 1
- NPL4-like protein
- DNA replication licensing factor MCM7
- SKA complex subunit 1 homolog
- Kinetochore protein NDC80
- Ubiquitin thioesterase OTU
- Nuf2 family protein, expressed
- Os09g0277600 protein
Sequence:
MSAPMEVSFSAPPPPDAASAAAAAPSLVPAVSAAAVAATTVSCSPQPPTGSPSADDRILVSVEVLLHATSTARAEDVCAAVERMLEARSLSYVDGPVPIPNDDPFLLANVKRIQICDTDEWTENHKVLLFWQVRPVVHVFQLSEDGPGEEPGEDDTLSSFNEWALPAKEFDGLWESLLYEVGLKQRLLRYAASALLFTEKGVDPCLVSWNRIVLLHGPPGTGKTSLCKALAQKLSIRFKSRYSMCQLIEVNAHSLFSKWFSESGKLVAKLFQKIQEMVEEESNLVFVLIDEVESLAAARQAAISGSEPSDSIRVVNALLTQMDKLKSWPNVIILTTSNITTAIDIAFVDRADIKAYVGPPTLQARYEILRSCLQELLRVGILTHTQGGNSLCLLSYFSLMENQHCPEVADPHGSVHLSGLLHKAAEICEGLSGRTLRKLPFLAHASVANPSCCDASAFLHALIQTAQRELSESRG
Protein: 1,3-beta-glucanosyltransferase gas1 (EC 2.4.1.-) (Q9P378)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:17230583}. Membrane {ECO:0000269|PubMed:17230583}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17230583}. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Interaction partners:
- Cell wall protein ecm33
- Alkali-sensitive linkage protein 1
- Uncharacterized GPI-anchored protein SPAC212.12
- 1,3-beta-glucan synthase component bgs2
Sequence:
MKFSILSLAVAGLVGLAKASVSPVHVDGRYFFYENGTRFFLKGIAYQPNVDDSDTEGTLFVDPLSDGDACSRDVPYFQELSVNAIRVYAVNASLDHSACMQAFQDAGIYVLSDLAQPYEAISSSDPTWTVDLFSRYTEVVDSLAPYDNMLGFIAGNEVIQNNTNTNAAAFVKAAVRDVKSYIKSSGYRQIPVGYSTNDEEVTRDPMAYYFDCGDDDDHVDFYGINIYEWCGDSDFVSSGYQERTEEFSNMTVPMIFSEFGCIEVRPRTFSEIVALFSDNMTDVWSGGIAYQYFESENEYGVVTVSGDSVSTLTDFPYLSSRYASVIPSASYESTMSATLTATMSCQATNSAWMAATSLPPTPSEAVCECMDSTRSCVINDDVSSDDYSDLFSYVCNEISCDGITANGTYPGQYGSYSYCDAKQQLDYVLDAYYSAKGDCDFSGSATLVSASSATGTCASYLSAAGSSATNAISLTADSNAVSRNSSASTMSTSYTSGSGSSNSSGSSSNSSSKSSSGASSYNLNMVITFLSVVIGGTAVLFI
Protein: Kinesin-like protein (Q8MQ03)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Rac GTPase-activating protein 1
- Protein ECT2
- Incenp-like protein ICP-1
- Protein regulator of cytokinesis 1
- Kinesin-like protein
- Aurora/IPL1-related protein kinase 2
- Calponin-homology
- Anillin-like protein 1
- Serine/threonine-protein kinase plk-2
- Serine/threonine-protein kinase plk-1
Sequence:
MSSRKRGITPSRDQVRRKKLSIEETDSIEVVCRLCPYTGSTPSLIAIDEGSIQTVLPPAQFRRENAPQVEKVFRFGRVFSENDGQATVFERTSVDLILNLLKGQNSLLFTYGVTGSGKTYTMTGKPTETGTGLLPRTLDVIFNSINNRVEKCIFYPSALNTFEIRATLDAHLKRHQMAADRLSTSREITDRYCEAIKLSGYNDDMVCSVFVTYVEIYNNYCYDLLEDARNGSRVLTKREIRHDRQQQMYVDGAKDVEVSSSEEALEVFCLGEERRRVSSTLLNKDSSRSHSVFTIKLVMAPRAYETKSVYPTMDSSQIIVSQLCLVDLAGSERAKRTQNVGERLAEANSINQSLMTLRQCIEVLRRNQKSSSQNLEQVPYRQSKLTHLFKNYLEGNGKIRMVICVNPKPDDYDENMSALAFAEESQTIEVKKQVERMPSERIPHSFFTQWNSELDGSVRMEDDGSREIPCPPTFCLTDCNDKDTVDSMYKYARKLSSLQNSSEEGPSSTLLTMIRQYMMEADYQRVEIARLKDSLNDKDEEIKKLRGFCSRYKRENASMKERIASCEQGEQENALVMEKLMEQKMEDRKIIQSQKKAMRNVRGIIDNPSPSVASLRSRFDQENVAHPTAPIQTPPPPYQTPGRAPVFKKRLEATTSTTVMSGSSSGGSGQQGYVNPKYQRRSKSASRLLDHQPLHRVPTGTVLQSRTPANAIRTTKPEMHQLNKSGEYRLTHQEVDDEGNISTNIVKAPSKPPELQLEDSQSSSYSPCTDVKSITIYSNHDVEEEDE