Protein: Nonribosomal peptide synthetase 8 (EC 6.3.2.-) (Q4WVN4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence. However, contarary to other nonribosomal peptide synthases, NRPS8 does not encode a secreted peptide, but has more a structural role since it is involved in germ tube formation.
Interaction partners:
Sequence:
MSNNTMVNMSIEMKYDNDDTTSPDQKLPGLEALEMVKGAASVVAEIEPSSSASSIMGSREHHERMLGPLEVCVHDLVQEQSRQHGQTIAVHSIEKDLTYAELERYADWMAKYLMVKRDIQAGHIIPFCLKKSVWTMVAMLAIMKTGAACAALDPSQPVSRIKRILDDTEAPLVIVHRDYLGLAETLDVPSIVLGPDLWEGTSSGDTDKPLPVVDATQPAYIAFTSGSTGEPKGIVVPHRSIATSMREHGPATRVDTETRALQFASYTFDMSFQEMFTTLTHGGCVCVPSEAERWNDLAGAMERLGVNWAKLTPTVVRLLHPEQVPSLRTLVVGGEPITQDIIQTWAHRVDLIVSYGPAEASIMAAVSDPLAPTALPRVIGRQVGGTLHVVDAGNHDRLVEGSGEGELLIEGPILATGYLKDQSRTDATFIIDPKWVSCDSENVTTAPRRFLKTGDLVHRDEDGVLYHLGRKDFRLKLNGRLIDLAAIETCLLGSAQIASAVVIATREDTFWQQSLVAVISAKPTPSSRPDPHDAGHIRIQTQHDLMLPLIRDLKDVAQSALPDYMVPTVWLVVDSVPRLPSGKIHRRRVVQWLENLDEFTVQEIRSMQNHTPHCEPETAMERRLRDIWAEVLNMPVSTVSTMASFTGLGGDSVAAMRLARRCAAQGLEIDVQMILQNLSITELAPRVKVAEHSTDTSADNERFSIGISLDQLCQSLPPRLRSSITLDDVVDTYRCSPMQEAILLSRSRFQGYYDVRWVAEVVSIDQDTPISLQRVRDAWVDVVRRHPALRTFFVQDASTGNRLLTQVILGSFPPLVSIDHSQATLDGIMGVNAAESSDPLHQEPHRLSLFSLPTGQVFLKLELNHALSDGVSTALIFRDLSLAYSKALPSSPAPSFGGFIRRLNLGEAEASSTALKYWTDRLTGMVPCLFPVLREAAWTGPSAVQHVEIPIHGSQGALRRFCTQHGTTIANVFQTAWALVLSIYTGTDDVSFCYLVSGRDASVDNVDEIVGPLISIMVHRLTLSRSLALLQVLRQVQSDFTVALGHQHCSLAQIAHSLNLRGQPMSNTVVNVQRRFSQGGPDGVADVYIRGIDCCNPTEFAIAVDVEDWETYMTARLSYWESCISQTQAEGIAETLAEVIRNIQTNPLQTVGEVALVGDAVLAKLSTWNAVLPEANEACLPELVERQVISQPSAVAIDTDAEQITYISLWNLSGLLAGRLIDSGVQPRDLVAVCVPQSSWAVIAMLAIQRAGGACVPLDPKAPAQRWWEIISRTGISTVVTSETKKHIMSSQLPGLQVVSADGTEIDQHHLQGSGRVLPVLSVDSTAYVLFTSGSTGSPKGIDVPHRAICTSLCAHCPVLGITNETRSLQFAAYTFDASIEETFGVLVHGGCVCIPSEDTKMNGLVDFINRKAISWAFFTPSLVRLIDPDLVPSLQTIVLGGEAVGNDIFNTWSHRVDLINGYGPAEASICCAAAHLSLRQTQSPSTIGRAVGCRIWVVDPQNINRLLPPDCVGELLIEGHIVANGYWGDEERTASSFLPPPEFLQSLSLEYPADNFRRCFYRTGDLVRQRHDGSLIYVGRSDWQTKVNGQRVEIGEVEAQLSFHMAKNHSNHLSMVCVPKSGPWMKRLVAILSLDPEECTVGNRSNVVFCLDKPETAAMIRTISKGIESSLPPFMIPTVWIPVKQLPTLASGKINRRCVQEWVETSNEGIFLSVSRINSEAFGTSSTETTRGLTPTETVIRAIWSRVLNIPLHSIGLDNTFLSLGGDSISAMQVVYQAHREGLTISVQDIFHCKTVAKLGRHADHSSKNTSSSNLLAPPVDEVEVPFALSPIQQWFFESVPHKPAILNHYNQSAHFRVMKEIDHSQLFKALQHVVQRHAMLRSRFILDSWSWQQKITTDIEGSFRLEVESIDAITAFRSCCERAQKMIDIIHGPLLVAILVKVAEPAQHFLVLIGHHLSMDVVSWSIIHRELEAFLAGGQVIAPLSSTSFQQWARLHYEPNIVPAEPREVLPFSVLEADLDYWGMRDTANEYRHGEYITTSVDEETTASIFKEANIAIGTEPVELIMAAVLYSFGRIFHDRSLPALYMEAHGREGDEFGLDLSGTVGWFTTICPLQLHRESLHTWARAVAQVKDRRRSIPAKGWAYFACRTVSPKGQASFNHHQQMEILFNFTGSTGDINDEHDRFLSPVRLMEDSRSDFDPKTPRVALFAIEASVENRQLRFSVSYHRSMRHVPRVKQWIHSLPSTLQEGVQMLSTIGRQPTLYDCPLAALNYSDLDSILARIQQSQADMVVEEIYPCSHIQEGILLSSMRNPGHYQVRWLVKVEARRGLPVSTQRLAKAWQSVVRKHSILRTIFVDDPSGTSSFLQVVVEDPRYPASIVEVQHRDSVASLDEDIDFTVGELPYRATIYQLHDGNVFFLLDISHAILDGTSMGILAHELVRGYDGSLTGDEAPHYRDYIRLLQTMPRNETLAHWKAYLQDIEPCKMISRNNCVEKVITPEVRKVAVQLPSTESLQQFCKTYEVTFANILQAVWAVVLMHYSGSETVCFGYLSSGRDLPIPHVDRAVGPYINILPCAVRLQQSSSRLDVVKAIQADLYQNLAHEHCSLWQIHKELGLKGTTLFNTLVNFQKTTAAVEDASISLTTVASRDPSEYDLAFNVTDEGSSMTAELAFWSSFMDEPDANDLSRAVSRVFNEFVRSPEAVLHDLSPIGPLNVEQIVRLMPSPISGEQQCLHWLIEQWVCRTPDAPAVCSTELEWSYAKLHQLTTSLSHHLCQLGVGRNDRAAICMEKSPWVIVAMLAVLQAGAAFVPLDPSHPRTRRESMISSLDAQVLLISLDADEDAHLTMSSCRQVRVGSTRGAGSDTGVSSNLPKNEPDDAAYILFTSGSTGQPKGVVVPHRAVCSSIKAWSDMLNIRSTTRSLQFAAYTFDAAIGEIFAVLANGGCVCVPSESERLNFLPETITQLDVNWSFLTPSVIRQIDPSSVPTLQTLALGGEPLSKEVIETWCDRVHLINVYGPTETCVFSHANPITDSKQEPSLIGPPILGRSWVVSPFNIDILVPRGCIGELVIESPAVAAGYFNNPEQTAKAFIAPPRWWKLAQDALSGSNKRTEDELPRFYLTGDMVRQNVDGSITYLGRRDTQTKINGQRVELGEIEYHILRLPAVLHAFVGVPKGGPYESRLVAVVSLRSEDGSGRGEAVLPEDFRLEVVEPQIAARYTSDLIVHLERNLPAYMVPAFLVVVRQLPLQPSGKINRRMILSWLSEPTMAGLQKTQHNFTRREEEPTTLGPVEKQMREIWSEVLNLPVTRIRLDQSFFDLGGDSITAMQVVSRCRRSGLQLTVQDLLRWKTITKVTPRTISLSQVTGERVYSLTSAGSVVDMRSIASKLEAIGLPGRAGVKGVYACSPMQEGILLAALKSPGKYEVVLMLEIRATGSQDRVDLELLESAWLQVVDRHDMLRTVFLQEKTATGVFSQVVYKHIDPPIEITTVDDLDTLRSASFSAGHFDCIPYRVTLCKLSGSSLAYVRLDISHAVVDGWSLSILSRDLQQAYDGQLPSQPVAQYCELIQYLESQPQETSMEFWRHLLTGMVPCHLPNMISNSGSHSTQEVKLHQTRLEVDRNQELRDFCAAHDITIANVFQLAWAVVLYRYTGMEDVCFGYLISGRDAPIDNLEDAVGPFINILVARATLRQGISVKEFLGEIRDTFLAMSAHQHTSLTQIQHELAVGNLGLFNTALNVQHRALTQQNPHSDIEICELSGRDPSEFGAILNVIDAGNTLEFALSYWSDLLSEETGREICSFLSCILSAVLDNSGCSVKTVSQTAADAARSFIDRKGDGDISSTPRGNPAPECYRPLKEPTNLIALTVQQVCAEVLDLSVSSLSLDETFLSLGGDSLLAMKVVSRCREHGVALTVQHMLQNQTIREVFEHARFSDSFSYRQLRHTPDPTGIPFPLSPIQKLHFHLMPTGQNYYNQSFFLRVTERLEASAIERAVRLLVLRHSVLRARFNQQIDGAWAQVISPDIEGSYHFSATSLISWDDLWPLVEGAQKRLNIRQGPLLSVDVLNLQGGDQHIYLVGHHLVVDLVSWRIILADLEIILRGGELSHDPPLSFQTWIRLATEYAQDNIDPATTLPFQLRPGNFAYWGMAGIPNLAKDVSSLSFTLPTDITSSLLGPANASLGTEPTDLMIAALAHTFSLVFHDHSGLTIFQESHGREPWTPEIDLSATCGWFTVLTPLSVETDKVEFRNTLKRVKDLRRRIPGKGWPYFASRFASRRRTGQKLDEKDEIEVLFNFVGLYQQFNRNDSLFVRPVADVSLPPDFSPDSIRLALIEINSLVDGQGRMVMHVTYNSRMKRQEGLTAWLERSQQVLEEEMPKLLTAAPERTPSDFQLLSLSYNELSALESHCHKQFGLDLNAVEDIYPCSPMQEGILLSQVRDPSLYRVEWVADVRCVGGEAVDLGQLKQAWGQVVRRHPILRTIFVERDHDAGAYLQLVLNQSLFPSSCNSASAYKVLLHLPYHITFQCLPETDTVRITLQANHAIIDGVTLAILARDLGSAYGGELPDVSGPPFSDFVKFLRTRTIDKDLQYWSEFLSDSQPTLFPSLGSQLGPTPGAEDDLFVEKHIHFADGAKMHEFCATFGVTVLNLFQVAWALVLRLYTGQDDVCFGYLASGRDSNVSGIDDIAGPMINMLVCRLQPTRDKTPRELLKQAHKHLTLALSHQHVPLAEVQNRLRTHGTPLFNTLVNLQKSNVGQGISHLTISTIGANDPNEFTIGLQIADNGQSIDVLFGHWLSRVSVDQADLLASLLSSTVNNIMARPRARLGTINFCNGVHAQKMAEWNEQARRPVVESTLHSIIQDQARQRPSTIAIASTEAMWTYEELERAADQTARYLLRQGVQPGTILPFCMAKSPRAIVVMLAILKVGCACAALDPAHPPDRLKLIVQQTGAKFVISEPVVMDSLILDGTANILSLTDCGGSINEPGLTPCQLPSVKPTDIAFIMFTSGSTGTPKGVLIQHDSICTSIQYNGEAEMVTSSTRGLQFSSYAFDTSVDEIFTVLSRGGCVCVPTEAERMNHLAAFISRFDVNWLSITPTVARLIAPGEVPSVRTIVLGGEEIDPGVVNHWKDHAELVASYGPAEASIACAASPVTSVVGDALLGRPVASSLWVVDPSDHDALMPIGTAGELVIGGPLVARGYLNDPDRTSLAFVCPKWSTELNLPFNRFYRTGDMARWNVDGTLSYVGRLDTQVKLNGQRVELGEVERHLLAQPCLQCSTCAVPQSGLLANRLVGVIGLQTPQISAADGFHCLEISQARTLVPYASDAEESLRAKLPPYMVPTVWIGVQSLPLNASGKLDRRKVNKWLESFQDEDTLNIFQLVGSEQEAEDEPPLTPIQQTIRNIWADVLGRTSESIGLQRSFFALGGDSVAAIRVVAQCRQANLQLTVQDVFQARTIQSLAACATAIIEKPVETVSSLLEPSQCENPESELAKLDSEVLSGLGGPENIEEIYPCSPMQEGILFSRSSIGGSYDTRLVVEVLPRDGAEVDLDRLKNAWAAVVQRHPILRTVFADRPSDDSAFIQVTFRKYRPVIMGCETSEQSLDDMIAMPVQPFDDRRNPPHRFTICTSSQQRVFILLEISHVLTDAVSIDIIWRDLQLAYEGALTTSKAPRYSRFVSYLQGTSQKDHMAYWLKFLKDAEPCLFPHLGTGNQKGATRAVSVTISRAMTDHIRQFCASLQITVANLIQVMWSMVLRSYTGMDDVSFGYITSGRDLPLDGIDDLVGPLISMMISRVRYTPSMKVADVIKQVGQDTVASMAHQHCSLAAIHREVGLKSRSLFNTVLTVVRPHSTQSIDSSLQLTQIASSAGTSEFDVVLEVSDSGVELDTTLAYSESALRSEDATNLSQAIMCALNWIIAHPESLVDHLSLCSPDLISQMTAMNNASPEWELRQCLHELISLRAHRQPDSPALWTGQGTMTYSELDSKSTMLARQLISLGVRPGSLVPICLSKSTVAVLAMLAIMKAGGAFVPLDPLHPTQRLADLVQRTGAKLILSSANTRNSAEFAGPRVVEVEQLLSRVTSVNEIDGVCPAPDPEGIAYVLFTSGSTGVPKGVVVPHRAVCCSIRAHSEAMNINTTSRSLQFASYTFDACICEIFSVLVAGGTVCIPSEEERVHDLAGFITRSQANWAFFTPTVIRTLGLSPSQVPSLRTLVLGGEVVTVHDARTWAGHVSLFNGYGPTETCVFCATTPIHPDGVTYGRIGRPIGCAAWVVRPDNHDILLPPGCPGELLIEGPIVSQGYLNDPVRTQEAFITHPAWAQNRKLSQNQSSARRFYKTGDLVRQSPDGTLVYMARLDSQVKINGQRLDLGEIRHQIHSVVSEDVQVFIDLLPPTCLPNEKALLVAFLASTRFEPEQTSGFSPPIKALTSQLEQDLPRLLPRYMIPSVYLPLSAIPLTSGGKVDRQALRRRVSRMSMKELLVYTGEEQGTKLPISTAEEQQMQMLWAEVLRIPPETIGASDHFFRLGADSIDGMKLVALAQRHGILITLADIFRSPRLSDLATLLESPAHPDDSKHDLKSIIPAFSLLNVHSRNTVLKEIKADYALDVSQIEDIYPCTPLQESLMAASIQSHGAYVHHLVEKLPPSGEVPAIMSAWQSVIKMTPILRTRIVQTVSAGLLQVVLKESVQWLHRRQAIQEYLDEDARHSMTLGDPLLRLACLHDPGTPHTGHIVITIHHSIYDGWSLPHIRKLVYATQNGHPCSTSLPFNRFIHYLERKSDSRASDSFWQSFLYRSQPLAFPPLPSTGYQPVGTDSVQLSVHWPSTFPPSAFTLSTFVRVAWALVLGSYSGTDDVIFGLSLSGRDTPIPGILDILGPTICTVPFRVKFSGESIGALLERAHADSAAMLPYQHIGLHHIRQLGPDCQLACDFQTLLVIQPARDPSDPEPHSELTFTSSGGLTYAFALICQPHPSGIELHGDFDSNCVSRPVAERLLSQMKSVMGTLIFGDRRKLAAEVDVIDISQKATLATWQREPLQPGEGRVEDLIISRAQQAPDDLAIHAWDGELTYNELVEESATLAENLKRRGIGPGMLVPLCFVKSIYYVVTLLAVTRTGAAFVPIDPDAPIERMQKILKLTNACCILTSASLAEQTRAKAPARVAVFAIPLDRSARMSTDSDLMPGQSIVSHEAVYVLFTSGSTGIPKGVVVTHSSMKASLKAHGRRLGLSESSRVLQFSNHTFDVSLLEILTTLAYGGCVCIPSDGDRVNRLSEYMRDAKVNFAILTPSVARILSPVSVPDLRTLALAGEAWGQEIVNIWRDSVRLFNAYGPTEATILSAIGEVDAQCFRPNNIGSGSGALCWVTSPTDPTRLMAIGAAGELLLEGPILAQGYLGEEEKTRAAFIDPPMWRRELSSHGAPPCRSSLYRTGDLARYEEDGSITYLGRMDGQVKIRGQRTELSEIEHHILASDAVRNAVVLLRKNKLVCVLSLQSTSLTPAPSRPGDIRPVSDDDRDAALRICLSIRAGLARKVPEYMVPDLWVPVIDLPLSSSGKLARKGVDDWLASVDTKHLINLSLQKIPLSTTSPSPNIASSSVERAIRQVIAGALQLPVQQVSVDAPFTALGGDSITAILVASKLRNMGILLTMRDILEFPSIQHLASREDLTAPSPANLPLDVEQVNVPFELTPIQRFFFCFFPDGANHFNQSILVRVARRFTYDQWITSLRALVQRHGMLRARFSNVDNNLQQRITDESEGACCVKWHTLEAMDPSYISTALDRCERRIDIFQGPICAVEIFDFPHEQIFFIAAHHLVMDFVSQQILLKDLDSLLAGEELSTPRPLSFQAWSLKQIEYGSNLALSPQAVLPHHENVPLANLNYWGIAAMDSCYADSAVRVLEFDSTVTSSLVGDANRAFNSEPIELFIASLLHSFANTFTDRSAPAIFKEGHGRQTREPRLDPSSTVGWFTTITPIALAVSPQLSTFEDTLRRVKDICRAIPANGFDYFTSRFLNASGSSAFQSHGPMMEIVLNYAGVLNNVQQGGTLFCPIATEEQRQMRYHDINPQLRRFAVFDIYAQVAGGKLSFTFAYSPSLNYQDRISAWIESLRRLLEAISVDLPAKQPQKTLADYPRARLDYTALERLHKDIIPSLYPAKLDDVWECSPTQTVMLRARSYQPLFFSPHFIWKIAGTKASEGNRERLTKAWKRIVARHSVLRSVFTSQLTATYHQIVLANPPFFITWADMAGKESPSEALRRLPPLPSDELHLAFRLTASEDDEGDLFCRLDINHALIDHVSINVILSDVIAVYGGQPMDSDSAFSTFRDYVEYSHLRLVDGEPYWQDRLHDACPCVLTQRPYRQIPGVLFSKSVSVNASALKALCLSSGFTLASLFQACWAVLLQRYVGSDDVLFGYIASNRGLPIRGIDRMVGPLISILPRRVRLSPSASSVSEQVRAIAKHIHEQLHDDLEHHMSAGNTMAEVIQRGRCIEELLFPFDTAINFRSQPSAAVNSVSSDPTSPLQFADGQDPMPVSHQP