wanglab/gogpt-training-data huggingface dataset:
Protein: Ty transcription activator TEC1 (P18412)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: TEC1 is involved in the activation of TY1 and TY1-mediated gene expression. It is not involved in mating or sporulation processes.
Subcellular location: Nucleus.
Interaction partners:
- Down-regulator of invasive growth 1
- Protein STE12
- Mitogen-activated protein kinase KSS1
- Mitogen-activated protein kinase FUS3
- Flocculation protein FLO1
- Flocculation suppression protein
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Down-regulator of invasive growth 2
- Serine/threonine-protein kinase STE11
- Flocculation protein FLO11
Sequence:
MSLKEDDFGKDNSRNIESYTGRIFDVYIQKDSYSQSALDDMFPEAVVSTAACVKNEAEDNINLIDTHPQFELVNTGLGAKSDDLKSPSAKATFTDKQRKNEVPNISVSNYFPGQSSETSSTTESWTIGCDKWSEKVEEAFLEALRLIMKNGTTKIKIRNANFGRNELISLYIKHKTNEFRTKKQISSHIQVWKKTIQNKIKDSLTLSSKEKELLHLIEHGAEQTTENSNLFYDIFEEIIDSLPSVSDSGSLTPKNLYVSNNSSGLSVHSKLLTPITASNEKKIENFIKTNAASQAKTPLIYAKHIYENIDGYKCVPSKRPLEQLSPTELHQGDRPNKASFSNKKAILESAKKIEIEQRKIINKYQRISRIQEHESNPEFSSNSNSGSEYESEEEVVPRSATVTQLQSRPVPYYKNNGMPYSLSKVRGRPMYPRPAEDAYNANYIQGLPQYQTSYFSQLLLSSPQHYEHSPHQRNFTPSNQSHGNFY
Protein: NADH:ubiquinone oxidoreductase intermediate-associated protein 30 (F4I7I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MSRFRSLLQASVNATKKALTWNVEEWVPPAEKHIFKFHSKEDLKKWHLYSDSEYGGLSSASLEIPDKGDGSDCTGVFSGNLSVDLSEGSKWNISRSGFCGMRSKKFDGFIDLDGYDAIALRIRGDGRCYISTIYTENWVNSPGQSEDNSWQAFVFAPKDSWYTAKASPTTSIDIPLARYLPTWRGNVIDVEMEMNPGRVLGMSLSVNAEGGAVGAKSGAGDFRQCMIVFVVLGFSL
Protein: Meiotic recombination protein SPO11 (EC 5.6.2.2) (Cancer/testis antigen 35) (CT35) (Q9Y5K1)
Organism: Homo sapiens (Human)
Function: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Type 2 DNA topoisomerase 6 subunit B-like
- Superkiller complex protein 8
- DNA repair protein RAD51 homolog 1
- Histone-lysine N-methyltransferase PRDM9
- Meiotic recombination protein DMC1/LIM15 homolog
- Meiotic recombination protein REC8 homolog
- Serine-protein kinase ATM
- HORMA domain-containing protein 1
- MutS protein homolog 4
- Meiosis inhibitor protein 1
Sequence:
MAFAPMGPEASFFDVLDRHRESLLAALRRGGREPPTGGSRLASSSEVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSPKSAQKFSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI
Protein: RNA polymerase II-associated protein 3 (Q86PC1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSAQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNKEKELQKSPLSAANKDLPVRSHVQTDKSRKESASSSAASSPTEKQDLPVDPVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPHDPIYHINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRLRKIATKSGPNFTPDRPGMIEILPIEKPAYKRSKKAMRSVPVVDVVSPRATIDDSNQLRISDEDIDKIFNSNCGIIEEVKKTNPKPTPMPDTSGPPKAETIAKTSKEVKPTKQTAVKVAPAVETPKETETRKDTKIVPESDNEAKPSAPKKTAVEVPKVQTQVSPPKTTIERSPEVNTVQTEKIEQASSNNAMSPSPIERFLPPAPTSTAQFHVTWKELSGPQKYQYLKSIEVPNLCKILGAGFDSDTFADLLRTIHDFFVPNKEPNTAAVLLEISKNDEFTILAMLMSAEEKKMVSSILNAIKNWPSKNPAVLDNLFKEYGVA
Protein: Glycerol-3-phosphate acyltransferase 4, isoform C (EC 2.3.1.15) (RE02778p) (Q9W1B5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MIAVLLDIFWIPIGGFLSFLIFISAINKSIGVRKAYVNLLLRIFEYGRVSIETASKENQHIQNPKTDDKQGVQLVDDADSKEGTNGATLITRDAVLLPQPQEPAPEKPVSSTKDEINFDFEKCLDYVKSGVEAIIEDDVTSRFEAEELKSWNMLTRTNRHYEFISWKITSIWVFGFFIRYVILMPLRVLVCFVGVLFAVLSSSIVACLPFRFVRLSLASLSFKITFRLISSSMSSFIKFHNKQYKPTVSGFCVANHTSPLDVAILSTDCTYSLIGQRHGGFLGVLQRALARASPHIWFERGEAKDRHLVAERLKQHVSDPNNPPILIFPEGTCINNTSVMQFKKGSFEVGGVIYPVAIKYDPRFGDAFWNSAKYSMMQYLYMMMTSWAIVCDVWYLPPMYRQEGESAIDFANRVKSVIAKQGGLIDLVWDGQLKRMKPKKEWREIQQVEFANRLKSDST
Protein: Transcription initiation factor TFIID subunit 10 (Protein SALT TOLERANCE DURING GERMINATION 1) (TBP-associated factor 10) (AtTAF10) (TBP-associated factor II 15) (O04173)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Involved in osmotic stress adaptation during the germination stage and in gene expression related to meristem activity and leaf development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 12b
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 6b
- Ubiquitin C-terminal hydrolase 22
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 12
Sequence:
MNHGQQSGEAKHEDDAALTEFLASLMDYTPTIPDDLVEHYLAKSGFQCPDVRLIRLVAVATQKFVADVASDALQHCKARPAPVVKDKKQQKDKRLVLTMEDLSKALREYGVNVKHPEYFADSPSTGMDPATRDE
Protein: Probable serine/threonine-protein kinase PBL28 (EC 2.7.11.1) (PBS1-like protein 28) (Q84M95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in plant defense signaling.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9ZUF4}.
Interaction partners:
Sequence:
MHFPLVSAWNKRRRSKSYDTDPCTFLFSIIFARWHKRVYRTAECWQIEDQASQPRKRRFGSSVYTLKEMEEATSSFSDENLLGKGGFGRVYQGTLKTGEVVAIKKMDLPTFKKADGEREFRVEVDILSRLDHPNLVSLIGYCADGKHRFLVYEYMQNGNLQDHLNGIKEAKISWPIRLRIALGAAKGLAYLHSSSSVGIPIVHRDFKSTNVLLDSNYNAKISDFGLAKLMPEGKDTCVTARVLGTFGYFDPEYTSTGKLTLQSDIYAFGVVLLELLTGRRAVDLTQGPNEQNLVLQVRNILNDRKKLRKVIDVELPRNSYSMEAITMFADLASRCIRIESKERPSVMDCVKELQLIIYTNSKGGLGGTIPTFRRL
Protein: Ferritin (EC 1.16.3.1) (O16453)
Organism: Caenorhabditis elegans
Interaction partners:
- Ferritin
- NRAMP-like transporter smf-3
- Solute carrier family 40 member
- Solute carrier family 40 member
- NRAMP-like transporter smf-1
Sequence:
MSLARQNYHDEVEAAVNKQINVELYASYVYLSMSAHFDRDDIALRNIAKFFKEQSDEERGHATELMRIQAVRGGRVAMQNIQKPEKDEWGTVLEAFEAALALERANNASLLKLHGIAEQRNDAHLTNYIQEKYLEEQVHSINEFARYIANIKRAGPGLGEYLFDKEEFSD
Protein: T. brucei spp.-specific protein (Q384I3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEANGFPQWFAAWKRIRKAKEASVCVFKKKGGEGHEEGNKDGNRALHHRDTVNCGFADVDLHITRCGECRFFFVFFLVFYWYCYLFSFVRRYVKMPRWRARNVPCLSSCNSFPRFGSDLYLVEEQINKNNILLLPYV
Protein: Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Q383C1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03004, ECO:0000256|PIRNR:PIRNR016255}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit 8, putative
- protein-synthesizing GTPase
- Translation initiation factor, putative
- CSN8/PSMD8/EIF3K domain-containing protein
- RNA-binding protein, putative
- Elongation initiation factor 2 alpha subunit, putative
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Eukaryotic translation initiation factor 3 subunit L
Sequence:
MTEMLSCLVPYLDKHLVLGLLYFYDDQGVDVGDALRFVQATTALTPEGEVSLEQENKIRETAERARPALDMFFEQNVSDNCTYQLCLTESRIDELRGKGELSRGFLEKEGITPKVMTAVMDLAFLYYDAARYGDASELLSLLQCVTGYELGESKLLWGRLVCDTCSCRWPSAIAAAEKLWKQQGADGSENKSGKTTLRGDNGTSVTERVWLLHWALFPFFKGGNQYSTHLLNIVFDNKTDSIYQCVVETVCPHYLRYICAAAILNTHRRSALRRAAEMVGRIYEYSDPLTQLVREITNYRSFEDTLELLPKVSELAQGDYFLNLHADNLVENAKRLIFTQYVVTHSVVSIPYMAERLEMSAAGAEVWLADLISETKQRAKIDAVTGQMFVGSQVRSVHQTVLDRLEPVDHGRR
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (Q6IAU5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD
Protein: Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (Q9VZU8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367136}; Single-pass membrane protein {ECO:0000256|RuleBase:RU367136}.
Interaction partners:
- ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
- GDP-Man:Man
- Crossover junction endonuclease MUS81
- UDP-glucose 6-dehydrogenase
- Dolichyl-phosphate beta-glucosyltransferase
Sequence:
MVRVLFLHPDLGIGGAERLVVDAALALKERGHQVSFLTNHHDSTHCFKETADGTFPVHVVGDWLPRGLFGRFYAICAYLRMLYAAIYASFFMPQREQVDVVVCDLISVCIPVLRFAPHRPKVLFYCHFPDQLLSSREGLLKRLYRLPINWLEEHTIGLADKVLVNSKFTLRVFQDTFRRLSTVPDVLYPSLHTQYFDQMQKKLEQRSALLDEPVHPRVPLNAFIYLDINRYERKKNHALALHSLRLLGDMLPATDFKRCRLIIAGGYDTRCMENVEHFAELEHLTEELKLQDHVVLLRSPTDEEKCRLLFAAHCLLYTPENEHFGIVPLEGMYCSKPVVALNSGGPTETVVSTSTGFLCEKTEKSFGGAMLQLFRDEQLRVKMGDQGHKRVQQKFSFQAFADRLNGIIRDLVPISRESSAKKNK
Protein: FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) (Q13158)
Organism: Homo sapiens (Human)
Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24204270}.
Interaction partners:
- Caspase-8
- Caspase-10
- Receptor-interacting serine/threonine-protein kinase 3
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Tumor necrosis factor receptor superfamily member 10B
- Receptor-interacting serine/threonine-protein kinase 1
- TNF receptor-associated factor 2
- Tumor necrosis factor ligand superfamily member 6
- CASP8 and FADD-like apoptosis regulator
- Tumor necrosis factor receptor superfamily member 1A
Sequence:
MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS
Protein: HMG-box (High mobility group) DNA-binding family protein (Q58FU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPELSCTQHSKERKRLKLLFTVRNRKNRRCALMAIRPRTRKRVQAVRRAADGSAFKKCEECGVMIAIALYDMHECGEKRREVKRFKYIASGNIDNISKPIGSFEDEPRSPFVFFLEEFRENYNGDLVDASRICFNVWKNMSAEDQKPFNARAMEVDSAHSRKLNEEAKTIYKADEEADSKTVGRYDKFYESYVQIEEEEDYDSSDHFGHEFWEDDTMLDY
Protein: Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (U3JAG9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cilium-specific protein required for the regulation of cilium/flagellum formation. Involved in centriole duplication (By similarity). May play a role in melanosome trafficking.
Subcellular location: Chromosome, centromere {ECO:0000269|PubMed:19254375}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q9UPN4}. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q62036}.
Interaction partners:
- Centrosomal protein 70.
- Serine/threonine-protein kinase PLK
- Pericentriolar material 1.
- Centrosomal protein of 290 kDa
- Centrosomal protein of 72 kDa
- Si:ch73-162j3.4.
- Serine/threonine-protein kinase PLK4
- PDZ domain containing 4
- Sb:cb649.
- Centriole and centriolar satellite protein ofd1
Sequence:
MHTTRSPSASIQAGAAGDALDLSLNGSQLTMGRRPSSASPGKHFSRSISVSVAYDGRGKRNTLTDAGLGSSRAIKNLRRSNSTTQVNQQANTSLSSEGHTEDFLALFNSSSDGRRKLASLSKMSKDRTTWNILDDQPRVFPVPSSSHSTCSMDSPTGLKKREAGVSLAANFTANNRSNKAAVGNAVTAILHNNHSEKPLTPKSSNQKPSFNNLIKATVNDDVTLDVSGSLTKSQKNFSSASSSSNNNAPRSPRSPGQPRRREVTEEEAERYIQQVNHAAIIIQRWYRRHVNSKRANENIIKQLLASKKKEREQRAEEAKTTESLKKKEDDRKRIREEKARLARLTAIQELQQKRAQRAAEVQQIAEQETEALRHPGKVGRKKLTKSSPTSPTDIKAKNTDSNVNVVSDLDDVTNLRAASPAGSACRVSQCSQEILQRSVSMEDQRQGASSSRAQSKTTLNDLLDTLKLLEEEPERLSEPKSYRKDKYSWIDEDGDSNSLTTDNVERHRQLSQTPALPDGGALLSEAKLQSIMSFLDEMEKSEQERPRSVTSGSHREVVLSEEDLAVVEQASATAAEVTGSMMRLRLELDEKKRTVNMLQTALAQQRELTIRHVKETEKELNHTFQLQKEQYEATIQRHLTFIDQLIDDKKALSERCEEVVGELKQVDQKYTKKIAQMQEQHELVWQILGPMCEEIKKLKELMSATEKVRREKWINEKTKKIKEITVKGLEPEIQKLISKHKQELKKLRVLHEAELLQADERAAQRYVRQSEELRQQLEKEKDEQCQRERELAKQRFEKQLQEEENVLQQQRRRLYKEVSEEKERLTQLAARQHAELEDLRKQLEDNSSLAGRALREELEKSRDEQERRHQVEIKALKERLEIEKQTWEENYMKKEEAWLLSRERELKEEVRRGRDKEIELAIQRLEVETREAREECERAADNRMKRVREKYEAELRDLERSERTSLQKQQEMREKHSEMEAELLRLQSLLRQREQEISDLTQVTARDKLSEERRSLSEVIRQEFAERLIELEEENRRMKMEVSEAKARLRLEVERVTREKEEELAEVHQRVKSAILKKEETVNNLRKQHEAAVKRADHLESLLEQQRKQLLGK
Protein: Probable tRNA-splicing endonuclease subunit sen54 (tRNA-intron endonuclease sen54) (O74908)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).
Interaction partners:
- Probable tRNA-splicing endonuclease subunit sen34
- Probable tRNA-splicing endonuclease subunit sen15
- Probable tRNA-splicing endonuclease subunit sen2
- tRNA ligase 1
- Probable tRNA
- Pre-rRNA-processing protein las1
- RCC1 repeat-containing protein C10F6.04
- Ribonucleases P/MRP protein subunit pop3
- Decapping nuclease din1
- Large ribosomal subunit protein uL30C
Sequence:
MDAQDEDNPFTNLETTVDVTEEIQDWRFLSNVEKDQGTYTIPKRGQKDFEPDGTNKQHSALDLSRKAMFDALSVERLISAKHAIIATWNAQNGMSCVEKAHGPLFKTMGTADSQNRMWLLPEETLYLVERGSMECWSEEGLPMSLQAVYSASIPLCGSLENYLVYAHLRRCGFSVIRSNLVPVKEDEYRCDSKIMNFKDLLFLGLGKASQILQTFNFRKLAFPFSKRRRQSILLHDTFYTYEEVYHDLQIVRGYVPIACNLITSSDSLFQITFHAYKPSASFKKSALSEPDFRICVVSSQDTLLPTIFEIDALFSSTPLRQNMPQHMFQRLKEGYRNIIIAIVDYGVISYIRLSDVCFEEKVYTDFSKKGSKRKRVSKKFQQLV
Protein: Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7) (P23639)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-3
- Probable proteasome subunit alpha type-7
- Proteasome subunit beta type-7
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 7 homolog
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-1
- Proteasome subunit beta type-2
Sequence:
MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL
Protein: Unconventional myosin-VI (Unconventional myosin-6) (A0A590UJ40)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
Interaction partners:
Sequence:
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRSLDSYPVTSKNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQNAIESRQARPTYATAMLQSLLK
Protein: P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor) (Q93086)
Organism: Homo sapiens (Human)
Function: Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular location: [Isoform 6]: Cell membrane {ECO:0000269|PubMed:17001079, ECO:0000269|PubMed:20223879}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=The absence of the exon 10-encoded amino acids substantially results in subunit aggregation and retention in the cell cytoplasm. {ECO:0000269|PubMed:17001079}.
Interaction partners:
- P2X purinoceptor 3
- P2X purinoceptor 1
- P2X purinoceptor 4
- P2X purinoceptor 2
- P2X purinoceptor 6
- P2X purinoceptor 7
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2C
Sequence:
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKAGKFSIIPTIINVGSGVALMGAGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
Protein: Gamma-hemolysin component B (A0A0H3JX61)
Organism: Staphylococcus aureus (strain Mu50 / ATCC 700699)
Interaction partners:
Sequence:
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQICWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
Protein: Aminopeptidase N (EC 3.4.11.2) (Alanine aminopeptidase) (Lysyl aminopeptidase) (Q7D736)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MALPNLTRDQAVERAALITVDSYQIILDVTDGNGAPGERTFRSTTTVVFDALPGADTVIDISAHTVRRASLNDQDLDVSGYDEAAGIPLRGLAQRNVVVVDADCHYSNTGEGLHRFVDPVDGETYLYSQFETADAKRMFACFDQPDLKATFDVRVTAPAHWKVISNGAPLAAANGVHTFATTPRMSTYLVALIAGPYAAWTDTYIDDHGEIPLGIYCRASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAFGKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWDDLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLERFLAGLRDYFRTHAFGNASFDDLLAALEKASGRDLSNWGEQWLKTTGLNTLRPDFEVDAEGRFTRFAVTQSGAAPGAGETRVHRLAVGIYDDDGSKSSGKLVRVHREELDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSLQTALDRIADIAEPLPRTLVWSAAWEMTREAELRARDFVSLVSGGVHAETEVGVAQRLLLQAQTALGCYAEPGWARERGWPQFADRLLELAREAEPGSDHQLAYINSLCSSVLSPRHVQTLGALLEGEPAACGLAGLAVDTDLRWRIVTALATAGAIDADGPETPRIDAEVQRDPTAAGKRHAAQARAARPQFVVKDEAFTTVVEDDTLANATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARRSSEVAQSVVIGLYPHWDISEQGITAAEEFLSDPEVPPALRRLVLEGQAAVQRSLRARNFDADG
Protein: Potassium voltage-gated channel KQT-like subfamily member 5 (Q8K3W7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
IVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIG
Protein: von Hippel-Lindau tumor suppressor isoform 2 (A0A024R2F2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD