wanglab/gogpt-training-data huggingface dataset:
Protein: Geraniol synthase Tps-5073G30, chloroplastic (PfTps-5073G) (EC 3.1.7.11) (C0KWV6)
Organism: Perilla frutescens (Beefsteak mint) (Perilla ocymoides)
Function: Monoterpene synthase (mono-TPS) involved in the biosynthesis of monoterpenes natural products. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into geraniol.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MCSISQKVVIGLNKAAANNNLQNLDRRGFKTRCVSSSKAASCLRASCSLQLDVKPAQEGRRSGNYQPSIWDFNYVQSLNTPYKEERYLTRHAELIVQVKPLLEKKMEAAQQLELIDDLNNLGLSYFFQDRIKQILSFIYDENQCFHSNINDQAEKRDLYFTALGFKLLRQHGFDVSQEVFDCFKNDNGSDFKASLSDNTKGLLQLYEASFLVREGEDTLEQARQFATKFLRRKLDEIDDNHLLSCIHHSLEIPLHWRIQRLEARWFLDAYATRHDMNPAILELAKLDFNIIQATHQEELKDVSRWWQNTRLAEKLPFVRDRLVESYFWAIALFEPHQYGYQRRVAAKIITLATSIDDVYDIYGTLDELQLFTDNFRRWDTESLGIPPYSMQLFYMVIHNFVSELACEILKEKGFIVIPYLQRSWIDLAESFLKEANWYYSGYTPSLEEYIDNGSVSIGAVAVLSQVYFTLANSIEKPKIESMYKYHHILRLSGLLVRLHDDLGTSLFEKKRGDVPKAVEICMKERNVTEEEAEEHVKYLIREAWKEMNTATAAAGCPFMDELNVAAANLGRAAQFVYLDGDGHGVQHSKIHQQMGGLMFEPYL
Protein: Hairy/enhancer-of-split related with YRPW motif protein 1 (Q8AXV6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional repressor which functions as a downstream effector of Notch signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Protein jagged-1a
- Hairy/enhancer-of-split related with YRPW motif-like protein
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Delta-like protein
- Protein jagged-1b
- Recombination signal-binding protein for immunoglobulin kappa J region a.
- Delta-like protein
- Neurogenic locus notch homolog protein 2 precursor
- Notch receptor 3.
Sequence:
MKRNHDFSSSDSELDENIEVEKESADENAGANSPLGSMSPSTTSQVQARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHAAGGKGYFDAHALAMDYRGLGFRECLAETARYLSIIEGLDNTDPLRIRLVSHLNSYASQREAHSGLGHLAWGSAFGTPPSHLAHHLLLQQQQQQGAPLARSTSSPPSSNSSSPSSSSPSAPSTEPRLSGTVISEAGQTGPLRVPPSTSLPPGLTPPTASKLSPPLLTSLSSLSAFPFPLSAFPLLSPSSLGPATPSSSLGKPYRPWSMEIGAF
Protein: Uncharacterized protein (Q57Y62)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTRVVGDGVLSRPPFAFLTVSVIIAALATHAFVEASVEATPHNLSELNEQLFKSSEFLVPNVSSSPCSVHHGCPHASMVWATGTFTAPDVLTPASFLVSANLTLQLNLCCGYKFNGRLLREQSRYDTFLYDLLRSTPFHTLTLGEKRRMFPRDRVVIFDTQRQPPHRYESSHVPSAEEMQRGNDGDGDVIVLVTGAVGPGIRRVPLQQPPTTTALNLPLSGLRGGFDMPLGSRTGNSSVGSGSAVDGAVGTSADIQLRVSNVAIKCKCPHTLLVMPVLHARPDTLPPISIVGLGSHCGVGQKLRSVTPEMDVKGKVLRQPVIQLANGGWAASLTLQPALLPATLVHWIITDTTAVTGAANAVLNVSLYTALREEVEGSGMVQPQITTSGYFSVIPHHTYNVMVTVSRGAATQTLSGLFVLRLPLTLEGKAAQFSNVTQPHFGVGRRLRLSRITREREELKQAFAMLPDEGRPSHTGYWIRTQTSDEVRGSDGSPPHVPHNPFSEAFVWYPLTVGRNVLSYYVRDMDEVCEPVLLEMQELWAVQALLLEPVTSPVTVCDDRISLEAFELRGLLETMRSRQRMLIRLAGDLPWEDLARSGGTQEVVEGHFKCTESGVGPCRIATGMGGSHFGVLQMLKRGVAELMWVVRVEVDTSYLQHIEQLRQRQGSDVVDDDNDNEGPFGGFLDPSLSRVISSDGRLTVIEVRSPSVLIVRRMSALPRRVDVKLPMHERRLTVRPPHPVIGQHEESLDERDKDTDIQITGRWVVNPPISLISVDETYAAELNTSAVPNIRQVLPEGTLQFIAEDPGEAVQDKLLAAPYTSRCPPRVVEYIVSLVAVPAPPVAPEFVPVYTEDGCVALSPPREPQKDEEVRWDIRPCQEASAPPYFSKEKQKVDLTKGYNGSADALVVVCGVEVDRWCEAMWSARNLVGSVTQTFSLRRCQRPPHLLFHKFSGGDRRGSGSPIDTLALPSVEWLDGGITTGDESQHTVTRSGDNSNTTDETMVHHEAQPRYFARRVIPIAGYAAAVHYTFNYSGSQGDYEVDFAYEHDAAHQLHVTASHFARTGLAVSDDRSGKSDEPNTFTDPDDSAAATTAGPLLLRRFVRPPTVGVSGSHEHGSNGKDNNEGIFSDEAAYWEMERHHRDYNIDRECDARFSHNNSQTGQYMQLHGLSNSSNYPFQYNVRLSLAAVAAAAELPSRKGAAAEFARRGMCLSRPGNISFLALNPRGLVDVIGVRDIAFCESTFNFSRHPWLHTKYHYDFTWTCENTATGRSSTDSNTADGVMMVEKRSPTFSILYQGSAGATPCKLTVYNALTETLESETFMLKRVHPAPVTLNFSVLSDNWAPGNCPMRRSGRQSNSFGSQSRTTAGKEGGEPLGKHQSSAAGMRTHWIVGKRAVLHVDAPADGRTSQWRAVTVVPAETTSVGTQRLLDSIQIIPLRQPHPRAILRGAGGATVLLNNIRVPGMYTLSHQHLDPVHPNVCPNVTVTETLHVTHARVLENELTVCGDTAVLTAAPLPQAINCSFTTRWEVVSVQTADNITLTDETNFSGIKFEDVSSPHTVVKGLPFGIVTVRWSVYASARTTDDDERRQKGQPGILVDYDTVRLLVLTENLRTTRLVTLSSSVEMLITGSTLGWVLVEPADRRASALLSARDPTLRVGRVYKNQTTSGIGGGGNNSGRSEDAPEETALFVGNLPVGTTHLQYELHASPRLFGAMLRKRCPFVQQRLLTIERVSAFLSVNTTLDHECDAYSGRGRFSICLHAEGIKPASSSNAVAAQEKPSSSNLGVHLVAPGDFENSIKSSAERLTASGCSLPWWVARTTRWSDIKVDNSRQCISFTVIATEHHLQSKEVSHHLFLAQEHLSMSQPCHHTGGDFVPSEVIEGASTWSVGGSAEDSSWFRFRSRPAAEASDGLSKFLPFMNPSTLVREDRAMRPLLGQLGVADIVASELDISERTYMHWERSNATDRGAGMKNGSRSVDVVFHLDRSQPGRMASFLHATSSHPYAGQKGEGSHDHHQEREVMESFLAKCVRGTLRGSEVLTYWTEVNHPDGAAGGTAPEWEEYVRHVGGAEVTCEPLFASLEQLLRLPDDTESTLRSRRASFVPSKEQKFVSQEVVEQQLKALREEFRLTREGIDVTGLRPEVQQALARRRITKSQLDEIEKARREKAEKDRQHAQQQQQLVLTAATAAMTAEERFVAAARLYEGVTGEGVYAIRVKLPYYASFSVPHNLFLRTALHKDLICGTNISVTSTAPASLVLFSRVEVMDEPPAVGASPPAIKQCEVEGRVPTIFINVSGTRFVSGGAFPPQNVLLEELQNPDVIEEGGGPEGSTAGVGLASCLAQMRAGMDVSVDSATRKHLRLQLSPCPSFQMLSPIEYNEQQESGQLLKRLQLPRLLRITMRDALVQDSHTQGRTTISFVVEVRPTLALLHLRSLPSQGDSLPVVWAATGRKRPLLLCEADMRRKGVELGVELIGDTWNEHVGEDEEGAANPGDYGYSSDDYDADDDSNAPIVEGSGGWAVVNAGSSLNTRRLRPGQSEGRSRAGVGKRKRSPHSVALLNSFSIVEHHSFDSVHHLFLQQGGVYRSHFVSYFFSEVLKDPGNGQQQRLIYRYNDTFIGVRITSERNMQKDTLSSGTHDKYYMGASLVVDDGTNLLPPIRPFSTIEEILFAVPGIATECQGCLLADSTFFVAGDLTGLWSSPSMLQTRYLQSSQPARSTFSAPLRIPFYDAAVVPREWRFTTMCPTAALVALRSLWHSWNNQGVQPFLVMELVVYSLRDMLGGEVPLARRPAAILTSVSVPLGHLLKQTHVKTAQGEEMIPEIMFNVNTSAAARAYAMMAADFVRYGRAHVHSVHDYVRDEPQSGGALAVNGSVFLKVCVPAIPHSSTRGDGTPSQVNLDPQCSVVSFTHSLLLMEEPYAGAPYASWYRILWGLIYYPLLLLHHVVTAVVGYAALQQLPVRRLLLLRSPQDLHTASIGLTTMLFVALLFLCPLVEWLWVSLVLSLWAFVLYHERRLATAIVMIIHGLLWTFIL
Protein: Uncharacterized protein (A0A0H2UQ84)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSFIFNGIGRSNCVCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKAQKKEKIKVNKSNFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEPKKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAKQYADNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERAIKAKQYQKELEKDQRIASQDPIERKQKQTWILNSYFRELPEEKARFSRLLLEYRKSGEVPFSTEYLSDHLIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLERLVI
Protein: Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin) (Q9BVP2)
Organism: Homo sapiens (Human)
Function: May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12464630}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
Interaction partners:
- Probable rRNA-processing protein EBP2
- Pescadillo homolog
- Nucleolar GTP-binding protein 2
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Ribosome biogenesis protein BOP1
- GTP-binding protein 4
- Ribosomal L1 domain-containing protein 1
- Ribosome biogenesis protein WDR12
- ATP-dependent RNA helicase DDX18
- mRNA turnover protein 4 homolog
Sequence:
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEALLREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKSDLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGLWKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRNSLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERKQEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDDAYDFSTDYV
Protein: CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) (P27701)
Organism: Homo sapiens (Human)
Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19497983, ECO:0000269|PubMed:23897813, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:34530889, ECO:0000269|PubMed:8757325, ECO:0000269|Ref.4}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P40237}.
Interaction partners:
- CD63 antigen
- Tetraspanin-7
- CD81 antigen
- CD9 antigen
- Atypical chemokine receptor 1
- T-cell surface glycoprotein CD4
- Vang-like protein 1
- T-cell surface glycoprotein CD8 alpha chain
- Immunoglobulin superfamily member 8
- Leukocyte surface antigen CD53
Sequence:
MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISVLQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCRHVHSEDYSKVPKY
Protein: Radixin (ESP10) (P26043)
Organism: Mus musculus (Mouse)
Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus {ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:9472040}. Cell projection, stereocilium {ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668}. Note=Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (PubMed:30159668). Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. {ECO:0000269|PubMed:30159668}.
Interaction partners:
- Ezrin
- Na
- Moesin
- CD44 antigen
- Intercellular adhesion molecule 2
- Sodium/hydrogen exchanger 1
- Leukosialin
- Chloride intracellular channel protein 5
- Na
- Actin, cytoplasmic 1
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLRQIEEQTVKAQKELEEQTRKALELEQERQRAKEEAERLDRERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEQDENSAEASAELSSEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Protein: Pericentrin-like protein, isoform D (M9NFV3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MNLYTIYDWITSLLRPHGASVSYKAIEAATLEELPATSVATATSTAATSRATGGAAATCVDVEFIPTLNIIFEKPTSSSEQLQCAEKSEHVAGGVSDKEPADDCDSDNDSTRTYIISRSSWTGVTSSSSTPYAVTSTDTAELLRRQNNLSLTEEDQSVSSFSIEQPTSSITIEMADQRTTTTTTTTATTATTPSSANILATTATTTTTTSSSIEEEIEEAIEISEVEEQLNTPLESLSEAAAYARPKDEQSSAKSLSSNPAEDEDADEFRIDDAQLSGGQLAQHFLVDEDESEEGSDLPAASKVEVSLSSNDDDFDISLPLEQRKPVHSLHEDDESVDQSLSNQSTTDDVSELVEEPVHEMDDKTDGSAAISASAPQETQVDESQITDEQDHSMEEIVATNESIEVTYEAEETVNTSQKQDLITDLDEESEDQVHVDNRPTSTLQALKLPALQQPQIVERKAATALTTLRLQADVLEPLELTILEMDDDENEEDDDDEESSLQLMKLRLMAMNQQMIVDNAPKLSPTEAEQTQVTSSSNNLEIKQMERVPLTEFSKDVLEDITEESERLLSMSTTMEEEQDPPSLSLDESKTLLQPGAHKTGGSSSSLVSLNMLKQLEAKVQELHTQLETKDNCLASLNLQLETARRESSAGPASARDSSSLMTNSTEYRTLQEELGGPTLDIYVEMSRRDELIAKLTDSLQQSLNVRDKLQVDADRLGGEVQNLRRQLQETLDAVKRSSAVWPDQECNPGQRISEISMDLISESDDDLDRHFLTDNEERGSRSSKERQLTQLQTNEELGLQASNPEWTPTFSKQIEQFHTYLLPTEQRIFQMVQRKFDDYLNQQITLCRDLGAQELKIARDQWESEKLTSEQNQQAAHAKQMEDLRKYFEHKCADLEKQFSDDVFSHKSQHQTGDSSSECSEVDQLPEEGAAAVSSKEPSPRKRKRAELLLSPSHRQMTPCGLDSLGENTGKTEKDNTADIADLKIFYQTHIKELKRAHEDQVRKLSDRIKFYERQQGDDDYKSLLSENTVDDQHWPKELILLREKFTAKSQLEITQLNIKHAEEMSRLKLEFEKQLNRKNKRHLTFDAARDLEQVICERDGLRELSKSFRSVLCRLAKCVAHCEEDLNATLSEEVQRLLFHSRSQDGGDDLEATISSSLNNTKHMLRVPDVHSLLEVVEDPSLVQFIDSKSNEEPSEDFDLNDCLERLKSEASYLLHLSEDLHKQRTHDESSEHLDEPEKQEHELCCEAEDGLKTTGAVNQQVLSKFLRTNSLNDQQMGVANQRKNSNPEAGKTHSSLPPDLQEHAGNASELSFQLVQLKNRLIKSEADRQNLQQQLSRTIDRNAELGQELQALRDQLSQLNSLNHTDYNEGYGLGTMKSLQEQGLDQSSASFLALQERARHLLSSSPVKEQPSRDHGNSTVILLQMIEDFCREGDKVVEFSKKDREDLQSQYAQLESQFREVNQQLCESNAKRDKFEVELKASIDKIFVLREIISELETQVQTKALNEEVLAEKAQQLEEYVSLQMRDNDILQQEVHSLKTDIGEGYQSRIRVLEEKLKQSGPTAEQGVVLSQVAEKLRDIETTLDQKTKALESLHNSNATSNSASLSVTEDVSIHGSKEPTAVGSPSHPSLTVEGVQRVTEKLDRHTRVEEAAIKRIRDLEMQVHQMRAGCVELQHERDTLQGRMEEQTQRISTLQNRLEEQRQRAEQLHRTGTSDLNTRVHELQGEVQNLYEQLAARDKQMANMRQQLQRSKEEITRLETEVEVRTQPDRSLVNKLQAEVQQKGAEIVKLKDKIRTEMINRLAIPDLMETMLADKNDEIDHLRDQLEAKEKELQASQQEASQISSPSGAAGKQEGSGGKLSARTLSDIGSITEFPEPDVERRAAMRSLTALQMSEGAGGFLHQTMETSKEAVANLTHKRTDDLSGFIVPYPVNTFEHPHYFQALGVTAQSTDGLTPGLVPRQINFSNLTEDSKLKTTSLLMHTPELPRPTTPPEIHQLRVKLSDLQTEKQRQQSELEKKLQDLQKELEQEKEKLSRQAQTLQSYEESEAKYRLRIENLESKVLETAAQAASDRENLRKELNCVSAAHEQCENAAAARKRELEKLNSEVKVKADQLHAALRRCADLELQVLTLERDLERLKNSDNSSKQYSVDEIAQQVEKELNYSAQLDSNILKAIESEEENNLDKKLQKGVQTEEETLPGTGNGTDDENFTGERELLNQLEALRAQLAVEREQCEAMSKELLGEKQHSQDIQEQDVIIIEAMRKRLETALDAEDELHKQLDQERERCERLQTQLTSLQRAESRRNSSLLLKSPGDSPRKSPRADFESELGDRLRSEIKLLVAQNERERERSADAQRSSERERQRYEKELQERVAYCERLKQEMEKLSRDKESAETELEHFNERLTLQASEIESLEARLVTLQEAETRRANTRTRQHQENVKLQAEIHELKSKLLAAEAARDCLDQKVTQLRFDVSRSGQREAKLAEALAQANDRLAHSTDDNVPAQFMQKMKEINALLAENTQENRQMAETVQFLVGERIALQKKCEELGGAGNTNVTELEERCRQLIGRYLRVESHRKALVYQKRYLKLTLEGYQASEQLALQNLRGGAEQPPQRNIKKKFKTVALAIIAIQRIKYIGRIWHTGKRIVSKSVFTITQQRSPGLNLNVAPPQSPLPGPNSNLPTNNNNLMGRLSYAPLSPPMVNFSTVQPIMLPSDFTLQAPTTSLQTTIANNNSENTLPSLARLDWPTMQKPKRAHARHH
Protein: Uncharacterized protein, isoform N (M9PCX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNKVEFKNKNKDQGPCARVRKIRPINMGGNVEQRPWTPTVRIGKIAAETTNPGPATVQLPTLIGSKVPDSKKKAAPSYSFGHKLGGKYDTSGPGPAQYNVTGMRAKGRDYPRAATLQSRPKELTRFSNPGPGEYDVVPAAKAVIDATPKYTFGQRPVALKTFQIPAPGAYCPEKVKLNKTPEFSFGIKHHEQRPDYTPAPGTYKPEQVVLEHIPAYSFGLKTKHIQVSDTPAPGAYSPEKSRLHSAPAYSIAGKASQDVVDCTPAPGAYEPEKCVLSRTPAFSFGHRAELAKSSDTPAPGTYNPEKVRLDHTPAFTLSGRPETRSVSETPAPGSYAPEKYRNDRTPAFTFGGKHEQRLESSTPAPGDYCPEKVRHDHNPAFSFAGRHDLHKPSDTPAPGAYDTEKVRQDHNPAFSFAGRHDLHKPSETPAPGAYSPEKVRQDHNPAFSMAGKHSQKVTSDSPAPGDYCPEKVRLDHTPAYSFGVKSDPKVENNTPAPGDYHPEKVRQDHNPAYSFAGRHDLQKPDNTPAPGAYFPEKVRLDHNPAFSMAGKYDAKVTNDTPAPGDYSPEKVRQDTNPAYSFAGRHDLHKPSETPAPGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGDYSPEKCRLDHTPAYSFGGKNDPKVENNTPAPGDYHPEKVRLDHNPAYSFAGRHDLQKPSDTPAPGAYSPEKVRQDHNPAFSMAGKPVEKLTNGTPAPGDYSPEKVRLNHTPAYTFGGKNDPKVENNTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPNDTPAPGAYCPEKVRQDHNPAFSMAGKYTQKVANDTPAPGDYSPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHPEKVRQDHNPAFSFAGRHNLQKPSDTPAPGAYSPEKVRQDHNPAFTMAGKHDPKVSNDTPAPGDYSPEKVRLDYTPSFTFAGKNNPKVENDTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPSDTPAPGAYSPEKVRQDHNPAFSMAGKYIEKITNGTPAPGDYCPEKVRLDHTPAFTFGGKNDPKVENNTPAPGDYHPEKVRQDHVPAFSFAGRHDLHKPNETPAPGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGDYHPEKVRLDHNPAFSFAGRHDLHKPSETPAPGDYFPEKVRQDFNPAFTFAGKHDPRSLSESPAPGDYSPEKVRLDHAPAFSFGGKHDPKTEHLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAPCDYHPEQCQVDSTPAFTFGMRLGRERISDTPVRNNAECTTTTTNHTNNNAGSSTTTTTTTTTTTKTFINGVEQPELQKKETTKQVNGTHKELKSAPQAPLSNGNIVSNGNHSKMVSTTTRIQEVAHGQKESGNLKVVASGKSDASATKAAAVSHQTVVQADGAIVTSGQSSRMQTVKYAVEASSVQEKIISS
Protein: Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) (Q15393)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular location: Nucleus {ECO:0000269|PubMed:10490618, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000269|PubMed:28781166}.
Interaction partners:
- Splicing factor 3B subunit 6
- 116 kDa U5 small nuclear ribonucleoprotein component
- Splicing factor 3B subunit 1
- Splicing factor 3A subunit 3
- RNA-binding motif protein, X-linked 2
- Splicing factor 3B subunit 4
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
- Microfibrillar-associated protein 1
- Splicing factor 3B subunit 5
- Small nuclear ribonucleoprotein G
Sequence:
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF
Protein: Nicotinate dehydrogenase subunit A (EC 1.17.2.1) (Nicotinate degradation protein A) (Nicotinate dehydrogenase small subunit) (Q88FX9)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Function: Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6-hydroxynicotinate (6HNA).
Interaction partners:
- Nicotinate dehydrogenase subunit B
- Promiscuous aromatic aldehyde dehydrogenase, molybdopterin-binding subunit
- 6-hydroxynicotinate 3-monooxygenase
- Xanthine dehydrogenase subunit XdhB
- Isoquinoline 1-oxidoreductase, beta subunit
- Isoquinoline 1-oxidoreductase, beta subunit
- Nicotinate phosphoribosyltransferase
- Aldehyde oxidase and xanthine dehydrogenase
- Putative metabolite transport protein NicT
- Xanthine dehydrogenase accessory factor
Sequence:
MQTTISLQVNGQPVEVSAMPDTPLLLILRNDLCLNGPKYGCGLGECGACTVIIDGVAARSCVIPLAGAAGRNITTLEGLGSKAAPHPVQQAFIDEQAAQCGYCMNGMIMTAKALLDRIPEPSDEQIRNELSANLCRCGTHVEILRAVRRAAETRRKP
Protein: Major urinary protein 8 (E9PVW0)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKMLLLLCVGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIRVLENSLVLKVHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNAMDLVPEHVLVLTRQIAASRPENEEWPEPPVLSGDFSPGLHHHPFLSIQHPQYKFCDLHSILSH
Protein: Cobalamin biosynthesis protein CobD (P9WP93)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Adenosylcobinamide kinase
- Probable cob
- Cobyric acid synthase
- Precorrin-6Y C
- Cobalamin biosynthesis protein CobN
- Cobalamin biosynthesis protein CobIJ
- Corrinoid adenosyltransferase
- Precorrin-8X methylmutase
- Hydrogenobyrinate a,c-diamide synthase
- Precorrin-3B synthase CobG
Sequence:
MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDGRVAGAVHVGLLVGAVGLLGAALQRLPGRSWPVAATATATWAALGGTSLARTGRQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAENTADAQVVPLLWAASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAARLDDWANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHPSPNAGVVEAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQAGAAVLAVMLVYRRRP
Protein: Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40) (Q5PSV4)
Organism: Homo sapiens (Human)
Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- AT-rich interactive domain-containing protein 4A
- Histone deacetylase complex subunit SAP30
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
- Inhibitor of growth protein 2
- Inhibitor of growth protein 1
- Histone-binding protein RBBP4
- Histone-binding protein RBBP7
- SIN3-HDAC complex-associated factor
- AT-rich interactive domain-containing protein 4B
Sequence:
MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS
Protein: Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (P71832)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGVAVADSVLADYERVVDDVDLASISARERVLRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAAVARLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFLGFATVFNSVGQVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVALPDSFFAVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAVRAGMGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPRLTLGRDALEAALADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL
Protein: Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Q9GYZ3)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365053}.
Interaction partners:
Sequence:
MSVTTKQMVKPTVVVHRYLKESQRVCVWLVHETKMKIEGVLLGYDEFMNVVLGDATEVHLKTGEVVQLGKILLRSDNVGVIHPIGI
Protein: Growth hormone (Q0QBF8)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTLLCLLWTQEVGAFPAMSLSCLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTSKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F2X9C2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
PGGYFSKLSSGVDYCHRHMVVHRDLKPENVLLDHSKNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYMPEYLTRPVASLLLLMLQVDPLKRATIKDIREHEWFKQDLPGYLFPEDPSYDSTILDEEAVREVCDKFESTESEVMSSLYSGDPQDQLAVAYHLIIDNR
Protein: Multidrug resistance protein PmpM (H(+)/drug antiporter) (Multidrug-efflux transporter) (Q9I3Y3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Multidrug efflux pump that functions as an H(+)/drug antiporter. Confers resistance to benzalkonium chloride, fluoroquinolones, ethidium bromide, acriflavine and tetraphenylphosphonium chloride.
Subcellular location: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
- O-antigen translocase
- Pyoverdine export ATP-binding/permease protein PvdT
Sequence:
MNSPALPLSRGLRIRAELKELLTLAAPIMIAQLATTAMGFVDAVMAGRASPHDLAAVALGNSIWIPMFLLMTGTLLATTAKVAQRHGAGDQPGTGPLVRQALWLALLIGPLSGAVLWWLSEPILGLMKVRPELIGPSLLYLKGIALGFPAAALYHVLRCYTNGLGRTRPSMVLGIGGLLLNIPINYALIYGHFGMPKMGGPGCGWATGSVMWFMFLGMLFWVNKASIYRASQLFSRWEWPDRATIGPLVAVGLPIGIAVFAESSIFSVIALLIGGLDENVVAGHQIALNFSALVFMIPYSLGMAVTVRVGHNLGAGLPRDARFAAGVGMAAALGYACVSASLMLLLREQIAAMYSPDPAVIAIAASLIVFSALFQFSDALQVTAAGALRGYQDTRVTMIMTLFAYWGIGLPVGYSLGLTDWFQEPTGPRGLWQGLVVGLTGAAIMLCIRLARSARRFIRQHERLQREDAEAASVLGR