wanglab/gogpt-training-data huggingface dataset:
Protein: Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) (Q8WYA0)
Organism: Homo sapiens (Human)
Function: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity).
Subcellular location: Cell projection, cilium {ECO:0000305|PubMed:23990561}. Cytoplasm {ECO:0000250|UniProtKB:O35594}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:36606424}.
Interaction partners:
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 25 homolog
- Intraflagellar transport protein 172 homolog
Sequence:
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLIL
Protein: Small ribosomal subunit protein eS19 (40S ribosomal protein S19) (P17074)
Organism: Rattus norvegicus (Rat)
Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P39019}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P39019}.
Interaction partners:
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein eS12
Sequence:
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVRPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH
Protein: Large ribosomal subunit assembly factor BipA (EC 3.6.5.-) (GTP-binding protein BipA) (O06563)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00849}. Note=Binds to ribosomes. {ECO:0000256|HAMAP-Rule:MF_00849}.
Interaction partners:
- Probable helicase HelY
- Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW
- Probable respiratory nitrate reductase
- Nitrate reductase-like protein NarX
- Probable respiratory nitrate reductase
- Glutamate synthase large chain
- Pullulanase
- Nitrate reductase alpha subunit
- GMP synthase
- GTPase Der
Sequence:
MPFRNVAIVAHVDHGKTTLVDAMLRQSGALRERGELQERVMDTGDLEREKGITILAKNTAVHRHHPDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKALAAHLPVILVVNKTDRPDARIAEVVDASHDLLLDVASDLDDEAAAAAEHALGLPTLYASGRAGVASTTAPPDGQVPDGTNLDPLFEVLEKHVPPPKGEPDAPLQALVTNLDASTFLGRLALIRIYNGRIRKGQQVAWIRQVDGQQTVTTAKITELLATEGVERKPTDAAVAGDIVAVAGLPEIMIGDTLAASANPVALPRITVDEPAISVTIGTNTSPLAGKVGGHKLTARMVRSRLDAELVGNVSIRVVDIGAPDAWEVQGRGELALAVLVEQMRREGFELTVGKPQVVTKTIDGTLHEPFESMTVDCPEEYIGAVTQLMAARKGRMVEMANHTTGWVRMDFVVPSRGLIGWRTDFLTETRGSGVGHAVFDGYRPWAGEIRARHTGSLVSDRAGAITPFALLQLADRGQFFVEPGQQTYEGMVVGINPRPEDLDINVTREKKLTNMRSSTADVIETLAKPLQLDLERAMELCAPDECVEVTPEIVRIRKVELAAAARARSRARTKARG
Protein: Transcriptional regulator (TetR family transcriptional regulator) (Q9RG61)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MARKTKEESQKTRDGILDAAERVFLEKGVGTTAMADLADAAGVSRGAVYGHYKNKIEVCLAMCDRAFGQIEVPDENARVPALDILLRAGMGFLRQCCEPGSVQRVLEILYLKCERSDENEPLLRRRELLEKQGQRFGLRQIRRAVERGELPARLDVELASIYLQSLWDGICGTLAWTERLRDDPWNRAERMFRAGLDSLRSSPYLLLADA
Protein: Contig An01c0450, genomic contig (A2QB71)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTASSETQSALAESPQSIVLHVLCPSLPPPNRFTLHDISPSTTISTLKARIAQTIPSEPSPETQRLIYRGKPLTNDAVALNDVLESSNDTEYSIHLVLPPAPVPHASTSARAPAPMPRGASGNPAPQSPFSSNRFTPQHLPHGQEIRYRGPALPAVPHEAEIGLALRRNIEAIRRQIDMQERGGPLGGVAAGTAGATSHSTTSTTTTASFAQQPAWPHVTPGLSHPGHSSISSDFTMASGSSGTANVHSNLPEEVRLRLQILRNQIAFGEEQLNRGVAPPMDHIIRIRTQLFALLDDQYQNPHAERDGSIESLLTRVFNIYTRADQLRVSQARTMPTPVLSGPPNPAPGQAPLYLLSSPNGYQALVASPRGAETMQSSLDTLRAMHSPTGASAPRTGAPPEIHNANAVVMENIVRQAVLNQRIENNGQLSFTRNLRRMWLFVRLYFFCYMFSEPGTWSRVVYVTLAVLVSLLSETGIPQQLYRMLVAPVQRHLEGLVHFAPDEPTPAPPGTQSTGQGNVPTAQPTGMRHQLRRVERSLALFIASLVPGVGERHVEVRNAAEAARNAERAREEEERRRQEEEATNAGTTGEAQAQAQESSENEQRETGENAPNTIPQTEN
Protein: Probable aquaporin PIP2-6 (Plasma membrane intrinsic protein 2-6) (AtPIP2;6) (Plasma membrane intrinsic protein 2e) (PIP2e) (Q9ZV07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Probable inactive receptor kinase At2g26730
- Probable aquaporin SIP2-1
- Terminal EAR1-like 1
Sequence:
MTKDELTEEESLSGKDYLDPPPVKTFEVRELKKWSFYRAVIAEFIATLLFLYVTVLTVIGFKSQTDINAGGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANMLSDGYNVGVGVGAEIIGTFVLVYTVFSATDPKRNARDSHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQKAWDDQWIFWVGPFVGAAIAAFYHQFVLRAGAMKAYGSVRSQLHELHA
Protein: Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-14] (Q62949)
Organism: Rattus norvegicus (Rat)
Function: Neuropeptide with neuronal depressant and sleep-modulating properties.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MGGCSTRGKRPSALSLLLLLLLSGIAASALPLESGPTGQDSVQDATGGRRTGLLTFLAWWHEWASQDSSSTAFEGGTPELSKRQERPPLQQPPHRDKKPCKNFFWKTFSSCK
Protein: Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) (P02686)
Organism: Homo sapiens (Human)
Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:22609403}. Note=Targeted to nucleus in oligodendrocytes.
Interaction partners:
- Myelin-associated glycoprotein
- Myelin proteolipid protein
- Calmodulin-1
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Calmodulin-like protein 6
- Calmodulin-like protein 5
- Myelin-oligodendrocyte glycoprotein
- Mitogen-activated protein kinase 1
- Transcription factor SOX-10
Sequence:
MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR
Protein: SD02173p (Q8MQX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQAVKDVASFVLVIQKHPKLVTYKAQAYNIKCVYQTGEKNVTLGFNVSMLTTAGTIANTGPPPICQMRIITNEGEEINSAEIGDNLKLQVDVEPATIYGGFARSCIAKTMEDNVQNEYLVTDENGCATDTSIFGNWEYNPDTNSLLASFNAFKFPSSDNIRFQCNIRVCFGRCQPVNCGGYNAFGRRRRSIADNSTDATAIATNSGVEGQLREEITISSNAILTFEKRSGQGLNDANIKPAAQRVEDICVSMVGLIIALVITALLALVAVAVAVSCWLMAYRRRPKTIAPLPHPPEFPNPLFSNPDAVPEPTPDYIS
Protein: Galectin (Q9N384)
Organism: Caenorhabditis elegans
Interaction partners:
- Bacterial colonization factor
- ET module
- Galectin
- MD-2-related lipid-recognition domain-containing protein
- C-type LECtin
Sequence:
MIGGGIGISFRNEFFNPQTPVNIPVQGFSNGARLRLVLLPTSADSRFHINLRTPDDIVLHFNARFDEGAVVNNSTSGGGWQSEDRHANPFQQNKIYTLEFVSNGGIISIFVNGAHFADFVERTPSHGVHLIEIEGGVHVHSAHVSH
Protein: Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) (Q61103)
Organism: Mus musculus (Mouse)
Function: Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92785}. Cytoplasm {ECO:0000250|UniProtKB:Q92785}.
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- AT-rich interactive domain-containing protein 1A
- AT-rich interactive domain-containing protein 1B
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- SWI/SNF complex subunit SMARCC2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF complex subunit SMARCC1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Actin-like protein 6A
- Zinc finger protein neuro-d4
Sequence:
MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLEALLRTDPLEKRGAPDPRVDDDSLGEFPVSNSRARKRIIEPDDFLDDLDDEDYEEDTPKRRGKGKSKSKGVSSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSRPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNLCGTSENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS
Protein: Ammonium transporter AmtB (Ammonia channel AmtB) (Ammonium channel AmtB) (P69681)
Organism: Escherichia coli (strain K12)
Function: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)). Transport is electrogenic. Following sequestration of NH(4)(+) at the periplasmic face, NH(4)(+) is deprotonated and neutral NH(3) is transported into the cytoplasm. Neutral NH(3) and charged H(+) are carried separately across the membrane on a unique two-lane pathway, before recombining to NH(4)(+) inside the cell. In vitro can also transport the larger analogs methylamine and methylammonium. Also acts as a sensor of the extracellular ammonium concentration.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:11847102, ECO:0000269|PubMed:12023896, ECO:0000269|PubMed:15361618, ECO:0000269|PubMed:15563598, ECO:0000269|PubMed:17040913}; Multi-pass membrane protein {ECO:0000269|PubMed:15361618, ECO:0000269|PubMed:15563598, ECO:0000269|PubMed:17040913}.
Interaction partners:
- Nitrogen regulatory protein GlnK
- Nitrogen regulatory protein P-II 1
- Sensory histidine kinase/phosphatase NtrB)
- Glutamine synthetase
- Nitrogen assimilation regulatory protein nac
- Bifunctional uridylyltransferase/uridylyl-removing enzyme
- DNA-binding transcriptional regulator NtrC)
- Aquaporin Z
- Glutamate synthase large chain
- Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Sequence:
MKIATIKTGLASLAMLPGLVMAAPAVADKADNAFMMICTALVLFMTIPGIALFYGGLIRGKNVLSMLTQVTVTFALVCILWVVYGYSLAFGEGNNFFGNINWLMLKNIELTAVMGSIYQYIHVAFQGSFACITVGLIVGALAERIRFSAVLIFVVVWLTLSYIPIAHMVWGGGLLASHGALDFAGGTVVHINAAIAGLVGAYLIGKRVGFGKEAFKPHNLPMVFTGTAILYIGWFGFNAGSAGTANEIAALAFVNTVVATAAAILGWIFGEWALRGKPSLLGACSGAIAGLVGVTPACGYIGVGGALIIGVVAGLAGLWGVTMLKRLLRVDDPCDVFGVHGVCGIVGCIMTGIFAASSLGGVGFAEGVTMGHQLLVQLESIAITIVWSGVVAFIGYKLADLTVGLRVPEEQEREGLDVNSHGENAYNA
Protein: Autophagy-related protein 31 (CIK1 suppressor protein 1) (Protein CIS1) (Q12421)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Preautophagosomal structure.
Interaction partners:
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 17
- Autophagy-related protein 13
- Autophagy-related protein 29
- Autophagy-related protein 11
- Autophagy-related protein 9
- Autophagy-related protein 2
- Autophagy-related protein 20
- Ubiquitin-like protein ATG12
- Sorting nexin-4
Sequence:
MNVTVTVYDKNVKYRLEENIKNNKGPSNDDQPAYNNESKSTDGSDYAMFPTNIKYIFEDNNDELVDSSDAALTAGIDKVGDELENVIIVQLDESGSLEDITLISDQYELLSHRTNSLSLEENQMRTLSSHGDDKSNDEEEELSVDSDRFRVDSDIELDVISQFCDLSPFLRDLSLNDLIKLYVTQNEQLQMLSNSV
Protein: Phosphate transport system permease protein PstC (P0AGH8)
Organism: Escherichia coli (strain K12)
Function: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Phosphate transport system permease protein PstA
- Phosphate import ATP-binding protein PstB
- Phosphate-binding protein PstS
- Phosphate-specific transport system accessory protein PhoU
- Phosphate regulon sensor protein PhoR
- Phosphate regulon transcriptional regulatory protein PhoB
- Phosphonates-binding periplasmic protein
- sn-glycerol-3-phosphate transport system permease protein UgpA
- sn-glycerol-3-phosphate transport system permease protein UgpE
- sn-glycerol-3-phosphate import ATP-binding protein UgpC
Sequence:
MAATKPAFNPPGKKGDIIFSVLVKLAALIVLLMLGGIIVSLIISSWPSIQKFGLAFLWTKEWDAPNDIYGALVPIYGTLVTSFIALLIAVPVSFGIALFLTELAPGWLKRPLGIAIELLAAIPSIVYGMWGLFIFAPLFAVYFQEPVGNIMSNIPIVGALFSGPAFGIGILAAGVILAIMIIPYIAAVMRDVFEQTPVMMKESAYGIGCTTWEVIWRIVLPFTKNGVIGGIMLGLGRALGETMAVTFIIGNTYQLDSASLYMPGNSITSALANEFAEAESGLHVAALMELGLILFVITFIVLAASKFMIMRLAKNEGAR
Protein: Probable aryl-alcohol dehydrogenase AAD4 (EC 1.1.1.-) (Q07747)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized oxidoreductase YKL071W
- NADPH dehydrogenase 3
Sequence:
MGSMNKEQAFELLDAFYEAGGNCIDTANSYQNEESEIWIGEWMKSRKLRDQIVIATKFTGDYKKYEVGGGKSANYCGNHKHSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERKKNGEGLRTVSGTSKQTDKEVKISEALAKVAEEHGTESVTAIAIAYVRSKAKNVFPLVGGRKIEHLKQNIEALSIKLTPEQIEYLESIIPFDVGFPTNFIGDDPAVTKKASLLTAMSAQISFD
Protein: ATP synthase subunit J, mitochondrial (O13931)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit d
- ATP synthase subunit 4
- ATP synthase subunit a
- ATP synthase subunit f
- ATP synthase subunit K
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit 5, mitochondrial
Sequence:
MSFFGLKRYSTPILKPMLPFFLGGAIVFYGTVKLRDAMMDSAEYRNDPRNPKAGKYGSDH
Protein: RNA helicase (EC 3.6.4.13) (DEAD box protein 6) (E7F1G8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- m7GpppN-mRNA hydrolase
- Eukaryotic translation initiation factor 4E nuclear import factor 1
- Enhancer of mRNA-decapping protein 3
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm7
- RNA helicase
- Decapping mRNA 1A.
- DNA-directed RNA polymerase subunit
- C19orf13-like protein
Sequence:
MATARTEIPASVMPVTKQNGQAKPMSLQTGSFSSSTPSGKTPVMPQKGSSIPQSSGGIRFGDDWKKCLQLPPKDTRVRTTDVTATKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERIDLKKDYIQAIVLVPTRELALQVSQISINMSKHLGGIKVMATTGGTNLRDDIMRLDEIVHVIIATPGRILDLIKKGVAKVDKVQMAVMDEADKLLSQDFVVLIEDIISFLPKKRQILLYSATFPISVQKFMTKHLQKPYEINLMDELTLKGITQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSTQRVELLAKKITQLGYSCFYIHAKMMQEYRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLITSEDRFNLKGIEDQLMTDIKPIPSSIDKSLYVAEFHSMNPDEEEAAHKTGELN
Protein: Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) (Q96ST3)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810, ECO:0000269|PubMed:16820529}. Nucleus, nucleolus {ECO:0000269|PubMed:16820529}. Note=Recruited to the nucleolus by SAP30L.
Interaction partners:
- Histone deacetylase 1
- Inhibitor of growth protein 2
- Methyl-CpG-binding protein 2
- Histone deacetylase complex subunit SAP30
- Histone-binding protein RBBP4
- Histone-binding protein RBBP7
- Histone deacetylase 2
- Nuclear receptor corepressor 1
- REST corepressor 1
- Sin3 histone deacetylase corepressor complex component SDS3
Sequence:
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
Protein: MAM and LDL receptor class A domain containing 1 (H0Y3D6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
XECPRGRSALLKGPPQEKPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSECPLNYCRNGGTCVVEKNGPMCRCRQGWKGNRCHIKFNPPATDFTYAQNNTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTESSVYSFSNPLYGTTSGSLETLSHHLK
Protein: Probable pectate lyase A (EC 4.2.2.2) (Q4WIT0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Probable pectate lyase E
- Probable pectinesterase A
- Probable pectate lyase F
- Probable pectate lyase D
- Probable endopolygalacturonase B
- Probable endopolygalacturonase A
- Probable endopolygalacturonase AFUA_1G17220
- Probable exopolygalacturonase Cgalacturonohydrolase C)
Sequence:
MKFVATLIACGLSGLALAAPTATVNSLGKRAADDAAFGYASLNGGTTGGAGGTTTTVSSYAAFTAAVSSDAKKVVYVSGPIKQSAKQVKVGSNTSIIGKDSTAVLEGFGLLVKEKSNVIIRNLGVKKVLAENGDAIGIQYSNNVWVDHVDVSSDRDHDKDYYDGLIDVTHAADYVTISNSYIHDHWKASLVGHSDNNGDEDKGHLRVTYANNYWSNINSRAPSLRFGTGHIYNSYFENVSDGINTRDGAQVLVESNQFVGSSKALYSTDDGYAVERDNDFGGAKNTALQGTLTTVPYSYSLLGSSKVKSAVVGVAGQTLKF