wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1) (Q16280)
Organism: Homo sapiens (Human)
Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Subcellular location: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q00195}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel beta-1
- Cyclic nucleotide-gated channel alpha-4
- Calmodulin-like protein 4
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Calmodulin-like protein 6
- Calmodulin-1
- Adenylate cyclase type 3
- Cyclic nucleotide-gated channel alpha-3
- Anoctamin-2
Sequence:
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP
Protein: Substance-P receptor (NK-1 receptor) (Tachykinin receptor 1) (I6UDB5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDPLYITSPNSSADNGSAGSPVNDTEVFGNQFVQPVWQIVLWAIAYCTIVLVSVVGNITVIWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFIYAVHNEWYFGLVYCRFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQQRLSSAETKLVVCVIWALALMLAFPQYYFSSTAQLPGRVVCYINWPEYSMWDFQKTYYVCVVVLIYFLPLLVMGCAYLVVGCFLWASEIPGDSSDRYREQLIAKRKVVKMMIVVVCTFATCWLPYHVYFIVHQFLPHLFEERYIQQVYLGIMWLAMSSTMYNPIIYCLLNDRFRAGFQQAFSWCPCVPQGSYEGLELKSTRYLQTQASIFRASRMETTVSTVMPTGDGELPENPNRSSVDLTSNGSSRSASKTVSESSFYSSNNVA
Protein: Unconventional myosin-Vb (Q9ULV0)
Organism: Homo sapiens (Human)
Function: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P70569}.
Interaction partners:
- Ras-related protein Rab-11A
- Rab11 family-interacting protein 2
- Ras-related protein Rab-8A
- Optineurin
- Ras-related protein Rab-25
- Ras-related protein Rab-10
- Rab11 family-interacting protein 5
- Exocyst complex component 6
- Rab11 family-interacting protein 1
- Ras-related protein Rab-11B
Sequence:
MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV
Protein: Polycomb group protein FIE1 (Protein FERTILIZATION-INDEPENDENT ENDOSPERM 2) (OsFIE2) (WD40 repeat-containing protein 153) (OsWD40-153) (Q6ZJX0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in the regulation of seed endosperm development, grain filling and seed dormancy. FIE2-containing PcG complex in seed endosperm regulates the expression of various transcription factors by trimethylation on histone H3 'Lys-27' (H3K27me3) of target genes. Involved in the overall expression regulation of a large number of nutrient metabolism genes. Involved in the regulation of seed endosperm development. Involved in the regulation of vegetative development, particulary in stem cell maintenance in the root system, where it maintains the suppression of key differentiation regulators.
Interaction partners:
- Polycomb group protein EMF2B
- Histone-lysine N-methyltransferase CLF
- Histone-lysine N-methyltransferase EZ1
- Polycomb group protein EMF2A
- Probable lysine-specific demethylase SE14
- Histone-binding protein MSI1
- Os06g0275250 protein
- Os02g0708600 protein
- Os02g0708500 protein
- Os03g0640201 protein
Sequence:
MAKLGPGQGLGCEAAVGLLAPSRKREYKACNKLTEGKRPLYAIGFNFLDFHYYEVFATVGGNRVTTYSCLKDGNFAILQAYIDEDKDESFYTLSWACDLDGTPLLVAAGSNGIIRVINCATEKLLKTFVGHGDSINEIRTQALKPSLIISASKDESVRLWNVHTGICILIFAGAGGHRNEVLSVDFHPSDIYRIASCGMDNTVKIWSMKEFWPYVEQSFTWTDLPSKFPTKYVQFPVLVAVVHSNYVDCTRWLGDFILSKSVDNEIVLWEPKTKEQSPGEGSIDILQKYPVPECDIWFIKFSCDFHFNQLAIGNREGKVFVWEVQSSPPVLTARLTNPQCKSAIRQTAVSFDGSTILACSEDGSIWRWDEVDHPKA
Protein: Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) (Q8R431)
Organism: Rattus norvegicus (Rat)
Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Fatty-acid amide hydrolase 1
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
Protein: adenylate cyclase (EC 4.6.1.1) (M9PID8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDVELEEEEERICLRTAEEGQLANMDDDKLVSDEVHLRQLSATPSSAFSLQHSRGSDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQASSSYMPSFRRIDQIETTISKSHNDALXPSTRTHWV
Protein: Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma) (Q9U9R7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May be required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in vesicle fusion with nsfA and probably SNARE proteins.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10727946}; Peripheral membrane protein {ECO:0000269|PubMed:10727946}.
Interaction partners:
- Alpha-soluble NSF attachment protein
- Vesicle-fusing ATPase
- Uncharacterized protein
- Golgi SNAP receptor complex member 1
- Syntaxin-7A
- V-SNARE family protein
- Vesicle transport through interaction with t-SNAREs homolog 1A
- t-SNARE family protein
Sequence:
MSDKLKSNKKLEGETFMKEGDKLSKTNIFRWKADWDSAALAYEKAANAFRSAKIYDSAKYCFLRLSLCQTHMDVYYLAAKSMENASAMAKELKETQECANLLLESCKLYRTNGNSFQAADTMTKAAKLLEDIDLNQTIKLLTDACELFELDDKDHFSGDTFKQTISMLLKHKKYTEAVDLMILQNRVFVKLEQNHDLHKSCLSVITISLATDDIVASKKYYEQFLDYPSFIHSQEGTTAQELITAFDNHDVDGVKKIVSRHIFNFLDNQVAKIAKNLSISKDSLNPTINSTAPQQQYSNTTTTTTNNTNNNNPTSQQDDDEDVL
Protein: Probable membrane-bound hydrogenase subunit mbhJ (EC 1.12.7.2) (Q8U0Z8)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Probable subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane, thereby conserving the redox energy in a proton gradient.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10852873, ECO:0000269|PubMed:11054105}.
Interaction partners:
- Membrane-bound hydrogenase subunit alpha
- Mbh13 NADH dehydrogenase subunit
- Membrane-bound hydrogenase subunit beta
- Mbh14 iron-sulfur protein
- Mbh8 NADH dehydrogenase subunit-integral membrane protein
- Hydrogenase
- Na+/H+ antiporter MnhB subunit-related protein domain-containing protein
- MrpA C-terminal/MbhE domain-containing protein
- Cation:proton antiporter
- Cation:proton antiporter
Sequence:
MTNNSERKRLEKRIAQLCKFIGRSPWVFHVNSGSCNGCDIEIIAALTPRYDAERFGVKLVGSPRHADILLVTGPVTNQSLERVKLVYEQTPDPKIVIAIGACPTGGSVFYESPFTNAPLDRIIPVDVFVPGCPPRPEAILHGVVLALEKLAKMIKGEVPPEEGEENE
Protein: Squamosa promoter-binding-like protein 10 (Q8S9L0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- AP2-like ethylene-responsive transcription factor TOE2
- Ethylene-responsive transcription factor RAP2-7
- AP2-like ethylene-responsive transcription factor TOE3
- AP2-like ethylene-responsive transcription factor SNZ
- AP2-like ethylene-responsive transcription factor SMZ
- Auxin response factor 17
- Endoribonuclease Dicer homolog 1
- Agamous-like MADS-box protein AGL8
- Floral homeotic protein APETALA 2
Sequence:
MDCNMVSSFPWDWENLIMSNQSKTENEKKQQSTEWEFEKGEGIESIVPDFLGFEKVSSGSATSFWHTAVSKSSQSTSINSSSPEDKRCNLASQSSPGDSSSNIDFLQVKPSTALEVPIASAESDLCLKLGKRTYSEEFWGRNNNDLSAVSMNLLTPSVVARKKTKSCGQSMQVPRCQIDGCELDLSSSKDYHRKHRVCETHSKCPKVVVSGLERRFCQQCSRFHAVSEFDEKKRSCRKRLSHHNARRRKPQGVFPLNSERVFDRRQHTSMLWNGLSLNTRSEEKYTWGTTYETKPTQMESGFTLSFQRGNGSEDQLFTGSTLSFSAFQTSGGFSAGKSNIQLPDKGVGECSGGLHESHDFYSALSLLSTTSDSQGIKHTPVAEPPPIFGTFPSHFI
Protein: Probable cationic amino acid transporter (Solute carrier family 7 member 14) (B0UYF2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May be involved in arginine transport.
Subcellular location: Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MSGLFAKLDPRRVQWGANWFAFRSRVLRTKPVESMLETSGGTGAHGTKLARVLSTVDLVSLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHSISGFMINHIGTLNGLGKGEQSYPDILALVIGILVTVIVALGVKNSVGFNNVLNVINLVVWVFIMIAGLFFVSGSNWDEGRFLPYGWSGVMQGAATCFYAFIGFDIIATTGEEAKSPNTSIPYAITASLVTCLTAYVSVSVILTLMVPYTEIDSDAPLMEMFSLHGFQTAKYIVAIGSIAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSTYTETPAVACVVSGFLSALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPEGDIHGFVNFLSEQNSKRKEGVLAECEKEACSPVSEGDDYGGVPTNTCGAKNLPSLGDNEMLIGKPDKSTYTASHPNYGTVDMSSGIESDETDSAYLLKLKKLLGPRYYTMRIRLGLPGKMDRPTVATGRIVTRCVVLLFILIFCFCSLIIFGSGQIADGQWWAVLLLVVLLLVLTLLVFIIIQQPENPKRLPYMAPCVPFVPASAMLVNVYLMLKLSTITWIRFGVWCFVGVLIYFGYGMWNSTLEITAREEEAHASTYQRYDMGVDDNFAVDDDLYPSGDQGPFQNWGKGGQQKQPQQEQSEPQSDGLDRLDNHRTSSSSSHSRAKSKASKPSPGFEALVVDDDLDDPLE
Protein: 16 kDa phloem protein 1 (AtPP16-1) (Phloem protein 16-1) (Elicitor-responsive protein FIERG2) (Q9M2T2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to both sense and antisense RNA. Can also bind sheared DNA and dodecamer DNA with a low affinity. Interacts with mesophyll plasmodesmata to mediate its own cell-to-cell transport and potentiate RNA trafficking (By similarity). May play a role in plant defense signaling (By similarity).
Interaction partners:
- Probable inactive leucine-rich repeat receptor-like protein kinase At3g03770
- Ribosomal L18p/L5e family protein
- G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Probable protein phosphatase 2C 79
- Translationally controlled tumor protein 2
- Uncharacterized protein At1g15430
- Beta-hexosaminidase 2
Sequence:
MAVGILEVSLISGKGLKRSDFLGKIDPYVEIQYKGQTRKSSVAKEDGGRNPTWNDKLKWRAEFPGSGADYKLIVKVMDHDTFSSDDFIGEATVHVKELLEMGVEKGTAELRPTKYNIVDSDLSFVGELLIGVSYSLLQDRGMDGEQFGGWKHSQVD
Protein: Endoplasmic reticulum junction formation protein lunapark-1 (ER junction formation factor lunapark) (Q17667)
Organism: Caenorhabditis elegans
Function: Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000269|PubMed:18279315}. Note=Localizes to three-way ER tubule junctions. {ECO:0000250}.
Interaction partners:
- DUF38 domain-containing protein
- Uncharacterized protein T19C3.4
- Replication factor A protein 1
- non-specific serine/threonine protein kinase
- BTB domain-containing protein
- Reticulon-like protein
- Nematode Specific Peptide family, group D
- F-box domain-containing protein
- Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
- GB1/RHD3-type G domain-containing protein
Sequence:
MGNLFSRNKSPATELERVALSIDDLKKRLQTISSSNTNTLYYYYMSIVVILSIAMAHTWLRFEDPQKTYVACALMLGAIGIVLAGRYVINGFFSWRTNRTTQKLENAISQKTTLLDLVKETLKFKEAKEILDRYEKIEQNTTIDKNDSTLKSPSPIKKLTADSSMFATPKQEQKRVETPTAQGPNSAMNSMNMTPYHQRNRNAVPIRPFLRQTTAFDRVLDYFMSDGPNCRNALICSICHTHNGMSTPAEYPYISFRCFECGHLNPAKKMGPQIPLTRPPMGPKGIQHNGRVGPSENTHNMMENQKPSTDLTPSASQNGSEKGSDSENEKVPESKTMETEFH
Protein: D-2-hydroxyglutarate dehydrogenase (D2HGDH) (EC 1.1.99.39) (P77748)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HGA) to 2-oxoglutarate. Appears to be the only D2HGDH in E.coli, providing the way to recycle D-2-HGA produced during L-serine synthesis by SerA, by converting it back to 2-oxoglutarate. The physiological molecule that functions as the primary electron acceptor during D-2-HGA oxidation by YdiJ in E.coli is unknown. Shows strict substrate specificity towards D-2-HGA, since it has no detectable activity on L-2-hydroxyglutarate, L-malate, D-malate, L-lactate, D-lactate, L-tartrate, D-tartrate, L-glycerate, D-glycerate, glutarate, or pyruvate.
Interaction partners:
- 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
- L-lactate dehydrogenase
- Uncharacterized protein YpjK
- Uncharacterized protein YggL
- NADH-quinone oxidoreductase subunit C/D
Sequence:
MIPQISQAPGVVQLVLNFLQELEQQGFTGDTATSYADRLTMSTDNSIYQLLPDAVVFPRSTADVALIARLAAQERYSSLIFTPRGGGTGTNGQALNQGIIVDMSRHMNRIIEINPEEGWVRVEAGVIKDQLNQYLKPFGYFFAPELSTSNRATLGGMINTDASGQGSLVYGKTSDHVLGVRAVLLGGDILDTQPLPVELAETLGKSNTTIGRIYNTVYQRCRQQRQLIIDNFPKLNRFLTGYDLRHVFNDEMTEFDLTRILTGSEGTLAFITEARLDITRLPKVRRLVNVKYDSFDSALRNAPFMVEARALSVETVDSKVLNLAREDIVWHSVSELITDVPDQEMLGLNIVEFAGDDEALIDERVNALCARLDELIASHQAGVIGWQVCRELAGVERIYAMRKKAVGLLGNAKGAAKPIPFAEDTCVPPEHLADYIAEFRALLDSHGLSYGMFGHVDAGVLHVRPALDMCDPQQEILMKQISDDVVALTAKYGGLLWGEHGKGFRAEYSPAFFGEELFAELRKVKAAFDPHNRLNPGKICPPEGLDAPMMKVDAVKRGTFDRQIPIAVRQQWRGAMECNGNGLCFNFDARSPMCPSMKITQNRIHSPKGRATLVREWLRLLADRGVDPLKLEQELPESGVSLRTLIARTRNSWHANKGEYDFSHEVKEAMSGCLACKACSTQCPIKIDVPEFRSRFLQLYHTRYLRPLRDHLVATVESYAPLMARAPKTFNFFINQPLVRKLSEKHIGMVDLPLLSVPSLQQQMVGHRSANMTLEQLESLNAEQKARTVLVVQDPFTSYYDAQVVADFVRLVEKLGFQPVLLPFSPNGKAQHIKGFLNRFAKTAKKTADFLNRMAKLGMPMVGVDPALVLCYRDEYKLALGEERGEFNVLLANEWLASALESQPVATVSGESWYFFGHCTEVTALPGAPAQWAAIFARFGAKLENVSVGCCGMAGTYGHEAKNHENSLGIYELSWHQAMQRLPRNRCLATGYSCRSQVKRVEGTGVRHPVQALLEIIK
Protein: Cytochrome c oxidase assembly factor 5 (Q86WW8)
Organism: Homo sapiens (Human)
Function: Involved in an early step of the mitochondrial complex IV assembly process.
Interaction partners:
- Cytochrome c oxidase copper chaperone
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
- Mitochondrial intermembrane space import and assembly protein 40
- Cytochrome c oxidase assembly protein COX19
- Protein PET117 homolog
- Protein SCO1 homolog
- Cytochrome c oxidase assembly factor 6 homolog
- Mitochondrial import inner membrane translocase subunit Tim9
- Cytochrome c oxidase assembly protein COX11
- Cytochrome c oxidase assembly protein COX14
Sequence:
MPKYYEDKPQGGACAGLKEDLGACLLQSDCVVQEGKSPRQCLKEGYCNSLKYAFFECKRSVLDNRARFRGRKGY
Protein: UV-stimulated scaffold protein A homolog (Q23088)
Organism: Caenorhabditis elegans
Function: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity).
Subcellular location: Chromosome {ECO:0000250|UniProtKB:Q2YD98}. Note=Accumulates at UV DNA damage sites. {ECO:0000250|UniProtKB:Q2YD98}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 7
- DNA repair and recombination protein RAD54-like
- BSD domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- DNA damage-binding protein 1
- XPA C-terminal domain-containing protein
Sequence:
MLKRRQPKYCSFMDSIDNSTTIIRKNLNRFIRELTDDGKLDFESIPYQNLQKEVANQDEEGCENVIEVLLDTTSRSGCPDRKLILQLFNSFFLQFPIFRENLLNDPSEFLELMFETNPIRNPLPGSKKHGNELKVEAITVIKSWEKEKCVKNDARMKCLVVTLKKTKFVDYENGAKKIEAERKRKKILEERKMKMIENSVNVYSSKYHEIKNDAETLSMELTTTMQMLVPSFTTADPEVPSTSTSTPSAISDSKSFEIFIPDLTPEISVSSENDAIVEAFLGAKLSLIHRVQTLRKLVKRLQLLKQPGEKLAQEIIDYRDGIKNLVLKADELRIINPRPPKNKRKKSDDDFIDVDISIDDILMVQYAEKLEVDVKSKDESEKITESPEKHKIEMKNEKPVKIKTVPFGLDLKYWGEERKDVEVPKNNADCHRFWRSADEGTVAGKAQQSIYTQRQYTFIGKAPDNRKVCLAKMKSGKLCPRKDYYTCPLHGKIVDRDDEGRPINEEDRLEENYRKEQNHLKEADKIRQMIEKEYESKTKRRKKHDVDTTASEDVRNRLQKKLLDPKTIQRVSADLDASRKNRLEKNFGQQFSHF
Protein: Cardiolipin synthase B (CL synthase) (EC 2.7.8.-) (P0AA84)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate.
Subcellular location: Cell membrane {ECO:0000305|PubMed:10634942}; Peripheral membrane protein {ECO:0000305|PubMed:10634942}.
Interaction partners:
- Inner membrane protein YbhN
- Uncharacterized protein YbhP
- Phosphatidylglycerophosphatase A
- Cardiolipin synthase C
- Cardiolipin synthase A
- Phosphatidylglycerophosphatase C
- Phosphatidylglycerophosphatase B
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phosphatidylserine decarboxylase proenzyme
- Phosphatidate cytidylyltransferase
Sequence:
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHALRKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRVETENTGVKP
Protein: Nicotinic acetylcholine receptor alpha6, isoform C (Q8IPE2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQLLITNLWLSLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ