wanglab/gogpt-training-data huggingface dataset:
Protein: Capsid vertex component 2 (P10209)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP. May mediate the capsid docking to the nuclear pore allowing entry of the viral genome into the host nucleus through binding to host nucleoporins NUP214.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04025, ECO:0000269|PubMed:16775316}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04025, ECO:0000269|PubMed:16775316}.
Interaction partners:
Sequence:
MDPYCPFDALDVWEHRRFIVADSRNFITPEFPRDFWMSPVFNLPRETAAEQVVVLQAQRTAAAAALENAAMQAAELPVDIERRLRPIERNVHEIAGALEALETAAAAAEEADAARGDEPAGGGDGGAPPGLAVAEMEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGATGSSGVVFGTWYRTIQDRTITDFPLTTRSADFRDGRMSKTFMTALVLSLQACGRLYVGQRHYSAFECAVLCLYLLYRNTHGAADDSDRAPVTFGDLLGRLPRYLACLAAVIGTEGGRPQYRYRDDKLPKTQFAAGGGRYEHGALASHIVIATLMHHGVLPAAPGDVPRDASTHVNPDGVAHHDDINRAAAAFLSRGHNLFLWEDQTLLRATANTITALGVIQRLLANGNVYADRLNNRLQLGMLIPGAVPSEAIARGASGSDSGAIKSGDNNLEALCANYVLPLYRADPAVELTQLFPGLAALCLDAQAGRPVGSTRRVVDMSSGARQAALVRLTALELINRTRTNPTPVGEVIHAHDALAIQYEQGLGLLAQQARIGLGSNTKRFSAFNVSSDYDMLYFLCLGFIPQYLSAV
Protein: HCG1820408, isoform CRA_a (cDNA FLJ40392 fis, clone TESTI2036913) (Q8N7T0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKKQGVSPKPLQSSRPSPSKRPCGASPAREREVEKSALGGGKLPGGARRSSPGRIPNLKKRKGLELKVVAKALLGPFQFVCNSLAQLREEVHELQARWFPSRTTLHRRLCGNSTLVTFSNTF
Protein: Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) (P69744)
Organism: Mus musculus (Mouse)
Function: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:12660155}; Multi-pass membrane protein {ECO:0000269|PubMed:12660155}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells. {ECO:0000269|PubMed:12660155}.
Interaction partners:
- Mucolipin-3
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Protein kinase C alpha type
- Protein kinase C beta type
- Protein kinase C gamma type
- Protein S100-A10
- Klotho
- Serine/threonine-protein kinase WNK4
- Transient receptor potential cation channel subfamily M member 6
Sequence:
MGAKTPWIQLQKLLNWWVRDQDWNQHVDQLHMLQQKSIWESPLLRAAKENDMCTLKKLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMEAAPYLVTESTLCEPFVGQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKRIQWSFGPLTSSLYDLTEIDSWGEELSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGALYIFYMVCFTTCCVYRPLKFRDANRTHVRDNTIMEQKSLQEAYVTYQDKIRLVGELVTVIGAVIILLLEIPDIFRVGASRYFGQTVLGGPFHVIIITYASLVLLTMAMRLTNVNGEVVPMSMALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTEDPDNLGEFSDYPTAMFSTFELFLTIIDGPANYRVDLPFMYSVTYATFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFLRVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLSRTTSLSSNSHRGWEILRRNTLGHLNLGLDPGEGDGEEIYQF
Protein: Neuronal membrane glycoprotein M6-b (M6b) (P35803)
Organism: Mus musculus (Mouse)
Function: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane. Note=Colocalizes with SERT at the plasma membrane.
Interaction partners:
Sequence:
MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQYRPVPNLGDRAGPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQSNGTSGVEQICVDVRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT
Protein: At1g65020 (Plasma protein) (Q5XF12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
Sequence:
MWIEIICGLVIYKLVRRFFYDDEFSDVETSDSTALFSVAHRLEKLYGGKAYVGLRIPDADTASRQDIDVVLVTKGDVVVISVKNLSGIVTVTSDGSWVCEGGKHHTTETFPDPLAEVKKQASVLESYLEQRGVTLLEGNVSCKVVIPNPSFRTIHAFPSEVITYEDWQQLKPVSKSKISGWVKGAFSTGKEMQESSHQKLNFILGTAPTWDRVELKSSKIVLGEFLEFKGKQEDTLALRNIKRSKVDRVSIQKTSMFGLAPSRLQVLYSYRDYRSEGSSGAESKEVTVRSSTEVLFQPRDSTKMKKFKLSSLVSISLSA
Protein: Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Q99986)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation. Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:31090908}. Cytoplasm {ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:31090908}. Nucleus, Cajal body {ECO:0000269|PubMed:21920476}. Note=Enriched on chromatin during mitosis. {ECO:0000269|PubMed:35390161}.
Interaction partners:
- Histone H2B type 2-E
- Ankyrin repeat and LEM domain-containing protein 2
- Barrier-to-autointegration factor
- Histone H2B type 1-C/E/F/G/I
- Histone H2A type 1
- Histone H3.2
- Histone H4
- Cellular tumor antigen p53
- B1 bradykinin receptor
- Barrier-to-autointegration factor-like protein
Sequence:
MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK
Protein: Aldo-keto reductase family 1, member C1 (Type 5 17beta-hydroxysteroid dehydrogenase (EC 1.1.1.62)) (Q3MHS3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- UDP-glucuronosyltransferase 2B1
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- UDP-glucuronosyltransferase
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- UDP-glucuronosyltransferase 2B15
- Steroid 17-alpha-hydroxylase/17,20 lyase
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- UDP-glucuronosyltransferase 2B37
- Cytochrome P450 1A1
- Polyprenal reductase
Sequence:
MNSKQQTVRLSDGHFIPVLGFGTYAPREVPKSKALEATKIAIDAGFRHIDSAAVYQNEKEVGLAIRSKIADGTVKREDIFYTSKVWCTFNHPERVQVCLEQSLKQLQLEYVDLYLIHFPMALKPEEDLKAKDENEKLLFDVVDICDTWKAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKHRPVCNQVECHPYLNQRKLLDFCKSKDIVLVAYSALGSHRETRCVDKSLPVLLADPVLCAIAKKYNWTPALIALRYQLERGVVVLAKSFTEKRIKENMQVFEFQLTSEDMKVLDGLNKNIRYMSGSRFQGHPDFPFLDEY
Protein: Transcription factor MYB87 (Myb-related protein 87) (AtMYB87) (F4JSU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that functions as regulator of genes affecting cell wall organization and remodeling. Activates genes related to the primary cell wall and represses genes related to the secondary cell wall and expansins. Required for the regulation of longitudinal cell growth in stems, leaves, petioles, roots, flowers and siliques.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Proline-rich family protein
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Protein BEARSKIN1
- Endo-1,4-beta-xylanase 5
- Berberine bridge enzyme-like 26
- UPF0496 protein At3g28300
- Protein RESPONSE TO ABA AND SALT 1
- AT-hook motif nuclear-localized protein 11
Sequence:
MGRAPCCDKMAVKKGPWSTEEDAVLKSYIEKHGTGNNWISLPQRIGIKRCGKSCRLRWLNYLRPNLKHGGFTDEEDYIICSLYITIGSRWSIIASQLPGRTDNDIKNYWNTRLKKKLLSKQGKAFHQQLNVKFERGTTSSSSSQNQIQIFHDENTKSNQTLYNQVVDPSMRAFAMEEQSMIKNQILEPFSWEPNKVLFDVDYDAAASSYHHHASPSLNSMSSTSSIGTNNSSLQMSHYTVNHNDHDQPDMFFMDGFENFQAELFDEIANNNTVENGFDGTEILINNNYLDHDISSFIDYPLYDNE
Protein: Transmembrane BAX inhibitor motif containing 1 (C9IZ27)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLI
Protein: E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3) (Q9Y6X2)
Organism: Homo sapiens (Human)
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O54714}. Nucleus {ECO:0000250|UniProtKB:O54714}. Nucleus speckle {ECO:0000250|UniProtKB:O54714}. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250|UniProtKB:O54714}.
Interaction partners:
- Signal transducer and activator of transcription 3
- Small ubiquitin-related modifier 1
- SUMO-conjugating enzyme UBC9
- Signal transducer and activator of transcription 1-alpha/beta
- Small ubiquitin-related modifier 2
- Transcription factor p65
- Sentrin-specific protease 1
- Signal transducer and activator of transcription 5B
- Histone acetyltransferase p300
- Signal transducer and activator of transcription 5A
Sequence:
MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHCSATPAPPPGRVSSIVAPGGALREGHGGPLPSGPSLTGCRSDIISLD
Protein: RRM domain-containing protein (Q93194)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MCLPTATPQTSLLYSQQMPMKNLYSQFPAGLLDTQSIQSLDTCPLLLQTASLPSLSHIGLPHSLESAVLHSASEPPMEMRIDTSKHFHVFVGDLSKDVSNELLKSTFTKFGEVSEAKVIRDVQTQKSKGYGFVSFPNKQNAENAIAGMNGKWIGKRAVRTNWAARKNSEENRDKLTFEQVFNSTKADNTSVYVGNISQQTTDADLRDLFSTYGDIAEVRIFKTQRYAFVRYEKKECATKAIMEMNGKEMAGNQVRCSWGRTQAVPNQALNPLPIDLSSLMMPTMLPTTIPLIQNPFLNYEPATLLYSSFPQW
Protein: Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) (Q9WTR2)
Organism: Mus musculus (Mouse)
Function: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 3
- Dual specificity mitogen-activated protein kinase kinase 6
- Thioredoxin
Sequence:
MAGPCPRAGVLERAGSCWQDPLAEALSRGRSSPAVTGRGCARSRPLSVVYVLTREPGPGVEPGSGTEAEPLPLRCLREACAQLQGTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLEVSSSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGAGTEALLTPLVGRLVRLLEATPTDSCGYFRETIRQDIRQARERFSGQQLRQELARLQRRLDSVELLSPDIVMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKYEGPVAPDLYCMCGRIYKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSEELRLIGMKLACLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPSGGPPLRAHFWLHFLLQSCQPFKMAPPQEDQCLVLVLEINKVLLPARLEIQGTDPMSAVTLSLLEPETQEDPSSWTFPVTSICGISTSKLDQRCCFLYALPPAQDVQLCFPSVERCQRFCGLIQVLVMNPDSSAPTEEAEGAREVLEFDYEYSETGERLVLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTPRPSGAPSGPSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQEVPTLAENLLEQEQDSRLSKIHVELLLRCLGAQIHTPNRRQLAQELRTLQAQLRAQSLGPALLKGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDAESEKKAVLPRSEESSKEESQQKPQESQALQSQLPPEQGPPSLMVELGLLRAETDRLRDLLAEKERECQALVQQALHRVHAETRKYAPASETPATLPKDQNLVRWLQELSVDPATIQTLLSHSFTLQTLLTCATQDDLVYTRIRGGMVCRIWRAILAQRAGATSVTPVPRDAE
Protein: Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (P09739)
Organism: Rattus norvegicus (Rat)
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Interaction partners:
- Troponin I, fast skeletal muscle
- Troponin C, skeletal muscle
- Troponin I, slow skeletal muscle
- Calcium-transporting ATPase
- Myosin regulatory light chain 11
- Actinin alpha 3
- Myosin light chain 1/3, skeletal muscle isoform
- Troponin I, cardiac muscle
- Tropomyosin beta chain
- Troponin C, slow skeletal and cardiac muscles
Sequence:
MSDEETEQVEEQYEEEEEAQEEEVQEEAPEPEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLSDDKLRDKAKELWDTLYQLETDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGATAKGKVGGRWK
Protein: Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.31) (Ditrans,polycis-undecaprenylcistransferase) (Undecaprenyl diphosphate synthase) (UDS) (Undecaprenyl pyrophosphate synthase) (UPP synthase) (P60472)
Organism: Escherichia coli (strain K12)
Function: Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
Interaction partners:
- Phosphatidate cytidylyltransferase
- Octaprenyl diphosphate synthase
- Farnesyl diphosphate synthase
- Undecaprenyl-diphosphatase
- Putative undecaprenyl-diphosphatase YbjG
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase
- Regulator of sigma-E protease RseP
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Ribosome-recycling factor
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Sequence:
MMLSATQPLSEKLPAHGCRHVAIIMDGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTSRFNSRLQERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQLAEKVQQGNLQPDQIDEEMLNQHVCMHELAPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDEQDFEGALNAFANRERRFGGTEPGDETA
Protein: RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Protein kinase B) (PKB) (Q8INB9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex. Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth.
Subcellular location: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation.
Interaction partners:
- Forkhead box protein O
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Raptor, isoform B
- 3-phosphoinositide-dependent protein kinase 1
- Gigas, isoform A
- LD23779p
- phosphatidylinositol 3-kinase
- FI03615p
- Serine/threonine-protein kinase mTor
- LOBE
Sequence:
MNYLPFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSWPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDMASTLGTSSHISTSTSLASMQ
Protein: Protein Tat (Transactivating regulatory protein) (P12506)
Organism: Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)
Function: Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs.
Subcellular location: Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04079}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04079}. Secreted {ECO:0000255|HAMAP-Rule:MF_04079}. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type. {ECO:0000255|HAMAP-Rule:MF_04079}.
Interaction partners:
Sequence:
MDPVDPNIEPWNHPGSQPKTACNRCHCKKCCYHCQVCFITKGLGISYGRKKRRQRRRPSQGGQTHQDPIPKQPSSQPRGDPTGPKE
Protein: Elongation factor Tu, mitochondrial (Q9Y700)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL36m
- Elongation factor Ts, mitochondrial
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein bS16m
Sequence:
MNSAKATSLLFQGFRKNCLRLNRISFASGLINRFTVPARTYADEKVFVRKKPHVNIGTIGHVDHGKTTLTAAITKCLSDLGQASFMDYSQIDKAPEEKARGITISSAHVEYETANRHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQMPQTREHLLLARQVGVKQIVVYINKVDMVEPDMIELVEMEMRELLSEYGFDGDNTPIVSGSALCALEGREPEIGLNSITKLMEAVDSYITLPERKTDVPFLMAIEDVFSISGRGTVVTGRVERGTLKKGAEIEIVGYGSHLKTTVTGIEMFKKQLDAAVAGDNCGLLLRSIKREQLKRGMIVAQPGTVAPHQKFKASFYILTKEEGGRRTGFVDKYRPQLYSRTSDVTVELTHPDPNDSDKMVMPGDNVEMICTLIHPIVIEKGQRFTVREGGSTVGTALVTELLD
Protein: Malignant T-cell-amplified sequence 1 homolog (Multiple copies in T-cell lymphoma 1 homolog) (MCT-1) (Q9W445)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulates translation as part of a complex with DENR. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR.
Subcellular location: Cytoplasm {ECO:0000255|PIRNR:PIRNR005067}.
Interaction partners:
- Density-regulated protein homolog
- Eukaryotic translation initiation factor eIF1
- Obg-like ATPase 1
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS17
Sequence:
MFKKFEEKDSISSIQQLKSSVQKGIRAKLLEAYPKLESHIDLILPKKDSYRIAKCHDHIELLLNGAGDQVFFRHRDGPWMPTLRLLHKFPYFVTMQQVDKGAIRFVLSGANVMCPGLTSPGACMTPADKDTVVAIMAEGKEHALAVGLLTLSTQEILAKNKGIGIETYHFLNDGLWKSKPVK
Protein: DNA 5'-3' helicase (EC 5.6.2.3) (A0A8I6AH26)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRVSGLLSARNGMGKGLDGAEATCHPQAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDTHGRQVPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTITNPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL