wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein uL30A (60S ribosomal protein L7-A) (L6) (RP11) (YL8) (P05737)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL33A
- Large ribosomal subunit protein eL20A
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL24A
- Large ribosomal subunit protein eL21A
- Large ribosomal subunit protein eL27A
- Ribosome biogenesis protein NOP53
- Large ribosomal subunit protein eL39
Sequence:
MAAEKILTPESQLKKSKAQQKTAEQVAAERAARKAANKEKRAIILERNAAYQKEYETAERNIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILSIDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLVKSMN
Protein: Rho GTPase-activating protein 1 (Rho-type GTPase-activating protein 1) (Q5FWK3)
Organism: Mus musculus (Mouse)
Function: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- Transforming protein RhoA
- Rho-related GTP-binding protein RhoC
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
- Ras-related C3 botulinum toxin substrate 1
- Rho-related GTP-binding protein RhoB
- Nuclear distribution protein nudE-like 1
Sequence:
MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKSPGQDPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVEVTQQVLQTLPEENYQVLHFLTAFLVQISAHCDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV
Protein: Ethylene-responsive transcription factor 8 (AtERF8) (Ethylene-responsive element-binding factor 8) (EREBP-8) (Q9MAI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ethylene-responsive transcription factor 5
- N-
- Protein OXIDATIVE STRESS 3 LIKE 1
Sequence:
MPNITMGLKPDPVAPTNPTHHESNAAKEIRYRGVRKRPWGRYAAEIRDPVKKTRVWLGTFDTAQQAARAYDAAARDFRGVKAKTNFGVIVGSSPTQSSTVVDSPTAARFITPPHLELSLGGGGACRRKIPLVHPVYYYNMATYPKMTTCGVQSESETSSVVDFEGGAGKISPPLDLDLNLAPPAE
Protein: Uncharacterized protein (Q55CK8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MVLSLLNYLVFGFKKLILFDKLVVVTGASSGIGLEITKELAKKGSKVILIARNENKLKEIIENIKIEYGNNQCYYISADLSKEEDLNNCLKEIGKISNDNGQYVEILVNCAGAGNWKFIEETSFKECNDMMSLPYFAAFNMTRLLLEPMLLHGEGTIVNINSPVSVNVWGGCIGYACSRWALKGFTECLRIDLRGTGVNVLEVIPGETKSEYFQHNGIGDDSFPLLSKFVPKVTVDQVAKGTIKAIENRKQKLILPLMLNVAKYFAFFPFSILLKYLLLSEKSRNRLIEIKLKQQQFKLKQQQFHNINNNKQE
Protein: Transcription initiation factor IIA large subunit (TFIIA large subunit) (TFIIA 32 kDa subunit) (P32773)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10525531}. Nucleus {ECO:0000269|PubMed:10525531}. Note=Imported to nucleus via interaction with KAP122.
Interaction partners:
- Transcription initiation factor IIA subunit 2
- TATA-box-binding protein
- Transcription initiation factor IIB
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIF subunit beta
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIF subunit alpha
- General transcription and DNA repair factor IIH subunit SSL1
- DNA-directed RNA polymerase II subunit RPB1
- RNA polymerase II transcription factor B subunit 3
Sequence:
MSNAEASRVYEIIVESVVNEVREDFENAGIDEQTLQDLKNIWQKKLTETKVTTFSWDNQFNEGNINGVQNDLNFNLATPGVNSSEFNIKEENTGNEGLILPNINSNNNIPHSGETNINTNTVEATNNSGATLNTNTSGNTNADVTSQPKIEVKPEIELTINNANITTVENIDDESEKKDDEEKEEDVEKTRKEKEQIEQVKLQAKKEKRSALLDTDEVGSELDDSDDDYLISEGEEDGPDENLMLCLYDKVTRTKARWKCSLKDGVVTINRNDYTFQKAQVEAEWV
Protein: Stage 0 sporulation protein A homolog (Q8XKA0)
Organism: Clostridium perfringens (strain 13 / Type A)
Interaction partners:
- Two-component sensor histidine kinase
- Two-component sensor histidine kinase
- Two-component sensor histidine kinase
- Two-component sensor histidine kinase
Sequence:
MFSIALCEDNSLQREELKNNLSKVLDEIGVEYKLLTFETGEDLLREYPENLDMLFLDIQMGELTGMETARKVRKYDDKVEIIFITALWDYIQKGYEVRAFRYLIKPVKFKELQEQVTACVENILHKRYTYITIKDKNNVLKIRTEDILFLETFERKVIIHTNSQDYIVKMSMNKLEKELNNKGFFRCHTSYIVNLIKIEEIKKDYLLINKFTLPVSKHRMKNLKLRLTSLLGDLIC
Protein: Neuromusculin, isoform A (Q9VNP2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGNMALRQSAKDVAKSNCVAVRSSISLSLVLVLCLALVDSSTAQVDTTISQQESQSVVLPCPVDAEKCGKLHSLNWFKGDDRIAAMLLGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVRWYANSTLLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAALSHFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLRGGRGPLQDIVTKDWTVEPVGLDSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSPNATLTCRIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANPEPSYKWIFKNETIANGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTVIKVQFKPRCEIERQEIDDQDTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYAISRTYRCVANNTVGYGPFCEIEVAEQLAWWQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRRRRQDKLHDKSSSLREPLTEPGEYENLPFHGLQTAPNKPINAQIFDDEFIYADLESQHYGPINYKAASLYSQVKKNKESGALDDLK
Protein: TAR DNA-binding protein 43 (TDP-43) (Q13148)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Negatively regulates the expression of CDK6. Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:17023659, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:28663553, ECO:0000269|PubMed:29438978}. Cytoplasm {ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:30464263}. Cytoplasm, Stress granule {ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:23398327}. Mitochondrion {ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:33031745}. Note=Continuously travels in and out of the nucleus (PubMed:18957508). Localizes to stress granules in response to oxidative stress (PubMed:19765185). A small subset localizes in mitochondria (PubMed:28794432). {ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:28794432}.
Interaction partners:
- RNA-binding protein FUS
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein A1
- Matrin-3
- Alpha-synuclein
- Ataxin-2
- Ribonuclease 3
- Superoxide dismutase
- E3 ubiquitin-protein ligase parkin
- Ras GTPase-activating protein-binding protein 1
Sequence:
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
Protein: Probable serine/threonine-protein kinase PLK (EC 2.7.11.1) (Polo-like kinase) (Q86HN7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- separase
- Aurora kinase
- Kinesin-related protein 12
- Probable protein kinase DDB_G0291133
- Double-strand-break repair protein rad21 homolog
- Structural maintenance of chromosomes protein
- F-box domain-containing protein
- Probable protein kinase DDB_G0277539
- Small GTPase
- Anaphase-promoting complex subunit cdc20
Sequence:
MVSINQNFKLPISMNSQPIQIQQQQFKQPQQQPQQKSNSCFSDQENYPANIQPSSSTSSSSSSSIHITKSMVIRPPLESNQPQPQQQQQQQQTLQQIHHQQVQLQQQQSLQMQQQQLQQQQQQQQQQQMPPPQSLPNKSNEPQEPIVVYETIRSGDSKRLKEYRQGEFLGKGGFAKCYLMTEVETNRIYAAKIIPKSTLQKTRARSKLKSEIKIHSSLSHENIVKFEHCFENEENVYILLELCNQKTVMDIHKKRKYLMEYETKYYVYQVIMAVQYLHNNNIIHRDLKLGNLFIDNMRIKLGDFGLSTKVEHGERKKTICGTPNYIAPEILDNSNGHSYEVDVWSIGIILYTLLIGKPPFETSDVKHTYQRIKQNQYSFPDEPIISHYGKSLIISILNPVPEQRPNLTQILEHDFFTYSPIPKYLPVSSLTTAPSQSTINQNMGRPLSEKTNIVNQQHLQLAGTTSPTKNNNHHYQQYQQQPQQQYNNNYQQSFSPKKQINNMNNNNNNNNNNNNNNNNNNNNNNNNLKQYNYSNNNINYNNNNNNINNQFANLSPNSQQKLSEVENDDFHYRKLRRLEKMKENDLKTQLLIKQQYTNMNENQQQQQQQQQQQQQQQQQQQRVNNNINNNGNTVTVTTGNNTVNVQIKELETKIANNHISDSPPVSSNNNYPQQIQKQQPNFNNEFYLGMPNNLVYISQYADFTNKYGLAYVLSNSYVGAYFNDSTKIVTLIESEIAYYMEHAKGTDGDGRRVLNVTQQHPHDTQKKVTLIKYFLNHFTNSDTTNLLINTGATSSSINNNNNNNVENVTNNNNNNSNNSSNINPIYVKKWIKFDNGIAFRLSDKTIQVNYLDKSRIIVSSKDMVTFVPYRGQIITGTLNYFKNGDKKISEKIKYIYGTLSNNLYSKKPESSFQQLPQQQYQQPQHYQQQTQQPQPQPQQQQLPQQLPQPQQSPAKQHQYQPNQIQYQQSIPQPQLINQ
Protein: Uncharacterized protein (Q382N7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLPSLIRRVAPSRVALVPLFAALKTTTLQQAPGGITQGDNRHPSCSGEDAALGALQQSPQSKLSLQEPLRPLTATAADGNSVPIVSNIARERGYIVDANRSYFSTGANKCSDATAIDGGVPQPVEDPLVHMLRCEEELLHTSVERLNAERKLAEMKRRFGDEMSALHEGLKAREEKVSRMVRRAARESGVHTHSVQPAAVVSYATATDDWGEVGKGVAGDIVDDGDNVGHRCGDDGEIADNGTQTPRLPDDTFVKLQDPEEDDASTEDDDISSSEVYADVPSPGRGQKRATSSEGTVAKRRGRPPSLKAASNKETKKHAGSRARGASARGERKDNAMRTASFARAASGSGKSPASRKVSQTKKAPQVGRASQTRKAVQAQRPLKQQQQRQSKVGANSRGRGSGVRGERGRRGTVGGDSKSITHPRGSTASGRQTAATRKRAGKK
Protein: Inner kinetochore subunit fta3 (CENP-H homolog) (Constitutive centromere-associated network protein fta3) (Sim4 complex subunit fta3) (Sim4-mal2-associated protein 3) (O94261)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore.
Interaction partners:
- Inner kinetochore subunit fta4
- Inner kinetochore subunit fta2
- Inner kinetochore subunit fta1
- Inner kinetochore subunit fta7
- Inner kinetochore subunit fta6
- Inner kinetochore subunit mis6
- Inner kinetochore subunit mis17
- Inner kinetochore subunit mis15
- Kinetochore protein mis14
- Inner kinetochore subunit mal2
Sequence:
MDNNDQISNLCLGALQLLADQPISVISNEPSEEQRNEHVLKKWENNVLRHWKILFSLFMQTCGDSVQGNAAFSILNFMTTNSLVGQLYQRLYDESNSLGFISSPLNETEHLSEENLKIESSITFTSEEIEKEKENIKSVLLPSVQSISSSLELYASKESDYRSSIEGVLADLKLARARWEIVRNVTQILLLESGISFLENKKLAYIMDLCGDREDNYSSY
Protein: Restriction of telomere capping protein 5 (O94644)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in a process influencing telomere capping.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Glutamyl-tRNA
Sequence:
MGQKESQFKVLWQLQTHEEYMKQTSSFLRDFNALERYNLKENFEALSSFDNGEKIWVEDAFTTFFGIPDVIQLSPFFYRSACSFGRDLNINRQRLTFSALARFLASYTGRHKDVWSDFESNLMIIASWCDSFPKFRVEVLKNSKQISRLIHSDVQNISNFFDQNFGIRRSNIYQLCLLLLCISKLKPGESVGCHINSFLDSMFVKEQKAAFYVLQGISPDISSNIIKPSYLLHFLESNPYFLKSLGSLFELALFPHSAHNQKVQDDVSPLNDFAILSPLIHAQICFFLPKSVWQVNGLTSLFRASFHGYSMYALERKMCNYHNPSILLIKAKKINANHKSSSRPISLDATIPRKYPPHCIGTDKAVPQKFGADFHNENILLGAYISTRWRQSHMGFFGDHSTLLFQLQPIHQVYYASNLDKNYCMFDKNVGLGFGLSRHKVTNKVQYDVPGVCMYIDDGLEYGLFRHAGDGAFKPATNYENFEYEERFLIQDLEVIGVDTTKPVEPIHIGL
Protein: X-ray repair cross complementing 6 (A0A8I5ZSS0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPTMCRVMSSIPSTAETHCDGNRLTASCLLLPSSGITDTCSIKMKQGSVPQQTLTELSVRLTLTDAFFPQCIQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKSIYVLQDLDNPGAKRVLELDRFKGQQGKKHFRDTIGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDDPHGNDSAKASRARTKASDLRDTGIFLDLMHLKKRGGFDVSLFYRDIISIAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSRLKFKLGKDVALMVGVYNLVQKANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTFGTRQIVLEKEETEELKRFDEPGLILMGFKPMVMLKNHHYLRPSLFLYPEESLVNGSSTLFSALLTKCVEKEVIAVCRYTARKNVSPYFVALVPQEEELDDQNIQVTPAGFQLVFLPYADDKRKVPFTEKVMANPEQIDKMKAIVQKLRFTYRSDSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKIAKRKADNEGSASKKPKVELSEEELKDLFAKGTLGKLTVPALRDICKAYGLKSGPKKQELLEALSRHLEKN
Protein: Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2) (Q92563)
Organism: Homo sapiens (Human)
Function: May participate in diverse steps of neurogenesis. Binds calcium.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Interaction partners:
- Matrix metalloproteinase-16
- Follistatin
- Thyroglobulin
Sequence:
MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHRIKQPTVKLHGNKDSICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPCPCPTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPASGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWREKPPCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDGGYIW
Protein: Response regulator (Q1DF43)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- Response regulator
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MMEDVAVAPARILLVDDEESLRITLAANLELEGHTVLEAANGEEALRLLEKQSVDVVLTDIRMPGLHGVELLRRIKQERPDMPVVLMTAFTAEELVDDALAEGAFTVLPKPFDVTHALDTVLRAAAAPQVLVVDDTEQVARGMVRALSTVGLRARAVYSGEEALASLRSGEYDVCVLDLVMPEMSGPELVSKVRAANLSVAIIAVSGHVVPEMLRRVAAQGAVVCMTKPVPLRELVQAIARVRGRPQQGLQGARI
Protein: Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] (P01192)
Organism: Sus scrofa (Pig)
Function: Stimulates the adrenal glands to release cortisol.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01193}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
Interaction partners:
- Melanocyte-stimulating hormone receptor
- Melanocortin-3 receptor
- Pro-neuropeptide Y
- Melanocortin 2 receptor accessory protein
- Melanocortin receptor 5
- Proenkephalin.
- Mu-type opioid receptor
- Proenkephalin-B
- Delta-type opioid receptor
- Kappa-type opioid receptor
Sequence:
MPRLCGSRSGALLLTLLLQASMGVRGWCLESSQCQDLSTESNLLACIRACKPDLSAETPVFPGNGDAQPLTENPRKYVMGHFRWDRFGRRNGSSSGGGGGGGGAGQKREEEEVAAGEGPGPRGDGVAPGPRQDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDELAEAFPLEFRRELAGAPPEPARDPEAPAEGAAARAELEYGLVAEAEAAEKKDEGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ
Protein: MIOREX complex component 11 (Mitochondrial organization of gene expression protein 11) (Q03079)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular location: Mitochondrion outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Meiotic mRNA stability protein kinase SSN3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- Transcription elongation factor SPT5
Sequence:
MTVMNLFFRPCQLQMGSGPLELMLKRPTQLTTFMNTRPGGSTQIRFISGNLDPVKRREDRLRKIFSKSRLLTRLNKNPKFSHYFDRLSEAGTVPTLTSFFILHEVTAILPLFLLWWLLYNLDLSDDFKLPNFLNGLMDSCHTAMEKFVGKRYQECLNKNKLILSGTVAYVTVKLLYPVRIFISIWGAPYFGKWLLLPFQKLKHLIKK
Protein: Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) (P35054)
Organism: Sus scrofa (Pig)
Function: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P26342}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342}.
Interaction partners:
- Transforming growth factor beta-3 proprotein
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
Sequence:
MTLHCVVALFALISSCLATAGPEPGVQCALSPVNASHPVQALMESFTVLSGCASRGTMGRPQEVHVLNLRAADQGPGQRQSEVTLHLNPISSVHIHHKPVVFLLNSPQPLVWHLKTERLAVGVSRLFLVSEGSVVHFSSGNFSLSAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPTCSIGKNFLSLNYLAEYLQPKPAEGCVVSGRPQEKEVHIIELIAPNSNPYSAFQVDIIIDIRPSRKDPELVKNLILILKCKKSVNWVIKSFDVKGNLKVLAPNSIGFGRESERSMIMTKSVRDDIPSTQEKLLRWALDNGYSPVTSYTVAPVANRFHLRLENNEEMRDEEVHTIPPELQILLDPGALPVLDHPPSGEGAARHGGLPFPFPYIPRRGRQDGGKDRLPRPKDPVVPSIQLLPGPREPQEAQGSRDVALSVRCDSEKMLVAVEKDSFQASGYPGLELTLLDPTCKAKTNGTHFILESPLDGCGTRHRRSAPDGVVYYNSIVIQAPPSGDSSGWPDGYEDLESGDNGFPGDVDEGDVALSSRPELVVFNCSLRPARHPSRAQDPPTRNVTFSMDLYTTDLFLAPAQGVFSVAENGHVYVEVSVTKADQELGFAIQTCFISPYSNPDRMSDYTIIENICPKDESVKFYDPKRVHFPIPQAETDKKRFSFVFKPVFNTSLLFLQCELTLCTKREKEPQKLPKCVLPDEACTSLDASMIWAMMQNKKTFTKPLAVIHHEVQFKGPSTKESNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGDSAGRQPVPTSPPASENSSAAHSLGSTQSTPCSSSSAA
Protein: Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) (P61924)
Organism: Mus musculus (Mouse)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit beta'
- Coatomer subunit delta
- Coatomer subunit beta
- Coatomer subunit gamma-1
- Coatomer subunit alpha
- Coatomer subunit epsilon
- Coatomer subunit gamma-2
- ADP-ribosylation factor GTPase-activating protein 2
- Vesicle-trafficking protein SEC22b
- Transmembrane emp24 domain-containing protein 10
Sequence:
MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2 (Q8LDK3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
- Transmembrane protein
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase iron-sulfur protein 8-A, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3-A
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 3-B
- NADH dehydrogenase 1 alpha subcomplex subunit 8-B
- NADH dehydrogenase 1 alpha subcomplex subunit 1
Sequence:
MGGGGHGGGITYKGVTVHTPKTWHTVTGKGLCAVMWFWILYRAKQDGPVVMGWRHPWDGHGDHGHGDHH