wanglab/gogpt-training-data huggingface dataset:
Protein: 11-hydroxysugiol 20-monooxygenase (EC 1.14.14.67) (Cytochrome P450 76AK1) (A0A125QZE2)
Organism: Salvia miltiorrhiza (Chinese sage)
Function: Monooxygenase that oxidizes 11-hydroxysugiol to produce 11,20-dihydroxysugiol. Can oxidize 11-hydroxyferruginol to produce 11,20-dihydroxyferruginol. These products are intermediates in tanshinone biosynthesis.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MQVLIVASLAFLAAWLVYSRWSDSRRRRGGGGSLPPGPPRLPIIGNMHQLGPNPHKSLAHLAKTYGPLMSLKLGNQLAVVASSPEMAREVLIKQGVALCRPFTPNAVCIHGHGEVSVLMLPATSNIWKRIRRIAREKLFSNPALQGTQDIRRERLRKLTDYAAGCSREGRAMNVGEATFTTMSNLMFATLFSIELTEYGASDAGANRKFREHVNAITTNMGVPNVADFFPIFAPLDPQGLRRKLTHHLGSLLELVQNLIDQRLQARDSSDYRKKKDFLDTLLDLSQGNEYDLSIKEIKHFFVDIIIAGSDTSAATAEWGMVELLLHPDKLEKLKAEMKSVVGEKSIVEESDIARLPYLRATVNEVFRLHPAAPLLAPHVAEEEARVNEYIIPKDTKVFVNVWAITRDPSIWKNPDSFEPERFLESDINFEGQHFELIPFGSGRRSCPGIPLASRMLHCMVGTLCHNFDWELEKGAESKQLQRQDVFGLALQKKVPLKAIPVKV
Protein: Lethal(2) giant larvae protein homolog SRO77 (Sodium protection protein 2) (Suppressor of RHO3 protein 77) (P38163)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.
Interaction partners:
- Protein transport protein SEC9
- Protein SSO1
- Lethal
- GTP-binding protein RHO3
- Protein SSO2
- Exocyst complex component EXO84
Sequence:
MFKKSRHLKNVSNAIKSARVHDVSNGINSKFFDTKKICTYGINGRITVTTFDYTQSLLAVATTAGEIHVYGQKQIEVVFTLKNRPQIKHMRFIKGIYLIAVDEKSNIIVLSVHSKQILTTVFCPNSITCIETDPSLDWMLIGLESGSILIYDVDRNQMSKLKIENFQKSVFLPKERLSPVISIQWNPRDIGTILISYEHITVIYSFIDYKVKQHFFYQLEPYAPGGDLSTNIEKKRTPKVIQSLYHPNSLHILTVHEDNSLVFWDVNSGKLIHARSIFETHVNFPNPALKDCSFTETPAIFKVSWLCQRNPEYTSLLIATKATENPCLPQEITMIDLGGTPMYSVTSFDAMSKYYAKPVQQKLFSLIGKAPLINFLPLPKASPYFGGCHDTNLILLLLEDGELETLIYPAGSFSSKASIFPRSLAWVRPTVTTCIAQSVQKNLWLGMMTIAQSESFLKGGIPATRNIRRHETRSALLTGHSNGSVRIWDASHSEVTDNAVFEVNTAKVLNRATNLAIKNISFASETLELAVSSEVGDVILFKFETNKFYGQLPKSDALQLKFSRFSLDDSKTILVDVSDRGPTNVKQGFIPSTVIHAKKGAVSAIMNSNIGFVAVGFIEGTLIILDRRGPAIIFNENIRVISKAGSSYVSTVHFCVMEYGDDGFSSILMLCGTDIGELMTFKILPATNGRFEVKFTDATKTNNQGKILGINSFAKDTGYSCSATISKMQGLSKGIAIPGFVTISGANDIRLVSPGKSKDTHALFKYPIATSGLSFIPIIDGKGERKLSTIMIVLLINGDIKVLTVPELKEVKNLRCPVPLSAQYVENSSILENGDIVIRTGKFQASLISVLNESATGTNHTADISQHTPIDTLYNPDLKIGYRPQVNSLQWARGTIYCTPYQLDELLGGIERPESKYEESAIARGCISSSSSNAARKLPPGTEDHRYARPVRSSGRSNGYGVLKSVSRAIETRLDTVETTINDYATTMGQTMNDAMEETGRDMMKSAVGF
Protein: SLC35A4 upstream open reading frame protein (SLC35A4 microprotein) (SLC35A4-MP) (L0R6Q1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38580077}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MADDKDSLPKLKDLAFLKNQLESLQRRVEDEVNSGVGQDGSLLSSPFLKGFLAGYVVAKLRASAVLGFAVGTCTGIYAAQAYAVPNVEKTLRDYLQLLRKGPD
Protein: Protein VTE6, chloroplastic (F4IBS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MATISSTLLLNSSRSALPLRFPKFSGFSSSSPFARSYRFGRRNLEPLSNGMLSSGSRADGATAAAASMEGVMTEAMKLIQSASPTWKSAVANNLLIFVLGSPLLVTGLSASGIAAAFLLGTLTWRAYGSAGFLLVAAYFVIVSAFVINLNGTAATKVKMTQKEAQGVAEKRKGRRGPRSVIGSSAAGCVCAFLSIYQVGGAAFSQLFRLGFVSSFCTKVSDTVSSEIGKAYGKTTYLATTFKIVPRGTEGAMSLEGTLAGLLASFFLASVGCFLGQITPPEAAVCVLASQIANLGESIIGASFQDKEGFKWLNNDVVNVINISLGSIVAILMQQFILQNWVK
Protein: Probable fructoselysine utilization operon transcriptional repressor (HTH-type transcriptional regulator FrlR) (P45544)
Organism: Escherichia coli (strain K12)
Function: May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.
Interaction partners:
- Fructoselysine 6-kinase
- Fructoselysine 3-epimerase
- Fructoselysine 6-phosphate deglycase
- Pseudouridine kinase
- Probable fructoselysine/psicoselysine transporter FrlA
- Trifunctional NAD biosynthesis/regulator protein NadR
- Threonine dehydratase operon activator protein
Sequence:
MSATDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQLFQERFDTRVVSDKKTIDIFAATRPQAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRITLTIDNKRH
Protein: Plasmepsin V (EC 3.4.23.-) (Plasmepsin 5) (W7JPD9)
Organism: Plasmodium falciparum (isolate NF54)
Function: During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence. Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including RESA, EMP2, EMP3, KAHRP, RIF/Rifin and STEVOR (By similarity). Also, by regulating protein export, plays an essential role in gametocyte development and thus parasite transmission to the mosquito vector.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31851913}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8I6Z5}. Note=During gametogenesis, localizes to the perinuclear ER in stage I-II gametocytes, and relocalizes towards the cell periphery as the ER redistributes in the cell in stage III-IV gametocytes. {ECO:0000269|PubMed:31851913}.
Interaction partners:
Sequence:
MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENKNDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTGSSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEGSQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPTFVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNVSIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKELDMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDFKTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCKGLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIFLKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
Protein: Polyketide cyclase/dehydrase/lipid transport superfamily protein (F4K3U7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- B3 domain-containing protein At5g06250
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
- Folylpolyglutamate synthase
Sequence:
MQKKREICGYRDKLDKTLSSPELTNHETLKSLLRNQLEECDENILDKRTDDVSKLLSKLRSVSMTDHQVSKLTNDGDWKLKHDLEDCRVMYREGLDGSPFHTLLVEGYMDGPIHECLCVSWESTLYKKWWPQYAFPPFRILKSTCLQKVGVGEQICLARFVHIENKDEVPWPLTEREMILHYFSFEYFKDGLVVILLNTISDLNSIGVSSTDIIIPESPDAVRMDLVGGFVLQKVTPQRSYFRTIGDMDIKLDLMPPSLMNFISRQLIGNGFRLYKKSVASVAKFDEDYSRALTDPLYTKIRRALYSTDEAVEEEPKLETNEVNGVTLPKHEHENNGDASVNKPVHCRRTVPEIEEEEESEESVYSEDGNEIAKTHVDMRRRFCVSPEVEQALGTLDRVIFMVRNITPVPETEELSPNRADDQAKQVSVLENIESVPQTQESSSDFSEEEKREEDTGQNQGMLNKGKNSSLQRKRKARCFAFRSWL
Protein: Glycine hydroxymethyltransferase (Serine methylase) (G3V4T0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGG
Protein: Avenacosidase 1 (EC 3.2.1.188) (26-desgluco-avenacosidase 1) (Protein As-Glu1) (Protein As-P60) (Q38786)
Organism: Avena sativa (Oat)
Function: Beta-glucosidase acting as a preformed defense system. Hydrolyzes the bisdesmosides avenacosides A and B to 26-desgluco-avenacosides exhibiting fungicidal activity. Can use beta-fucoside > beta-glucoside > beta-galactoside > beta-xyloside as substrates, but not alpha-glycosides, beta-thioglucosides and disaccharides.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:24226684, ECO:0000269|PubMed:8000004}. Note=Found in a fibrillar spherulite called stromacentre.
Interaction partners:
Sequence:
MALLCSALSNSTHPSFRSHIGANSENLWHLSADPAQKSKRRCNLTLSSRAARISSALESAKQVKPWQVPKRDWFPPEFMFGAASAAYQIEGAWNEGGKGPSSWDNFCHSHPDRIMDKSNADVAANSYYMYKEDVRMLKEIGMDSYRFSISWPRILPKGTLDGGINHEGIQYYNDLLDCLIENGIKPYITLFHWDTPQALADEYKDFLDRRIVKDYTDYATVCFEHFGDKVKNWFTFNEPHSFCGLGYGTGLHAPGARCSAGMTCVIPEEDALRNPYIVGHNLLLAHAETVDVYNKFYKGDDGQIGMVLDVMAYEPYGNNFLDQQAQERAIDFHIGWFLEPMVRGDYPFSMRSLVGDRLPFFTKSEQEKLVSSYDFVGINYYTSRFAKHIDISPEFIPKINTDDVYSNPEVNDSNGIPIGPDVGMYFIYSYPKGLKNILLRMKEKYGNPPIYITENGTADMDGWGNPPMTDPLDDPLRIEYLQQHMTAIKEAIDLGRRTLRGHFTWSLIDNFEWSLGYLSRFGIVYIDRNDGCKRIMKKSAKWLKEFNGATKKLNNKILGASSCCSGVTHGGGTA
Protein: Homeobox protein ceh-39 (Q22812)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways. Directly binds to 5'-ATTGAT-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development. Associates with condensed DNA during mitosis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:17720939, ECO:0000305|PubMed:23666922}. Chromosome {ECO:0000269|PubMed:17720939}. Note=During mitosis, localizes to metaphase and anaphase chromosomes (PubMed:17720939). In the hermaphrodite gonads, localizes to the nucleus from late pachytene to diakinesis (PubMed:17720939). Localizes to condensed diakinetic chromosomes (PubMed:17720939). {ECO:0000269|PubMed:17720939}.
Interaction partners:
- T-box transcription factor 18
- RNA-binding protein ASD-1
- XO lethal protein 1
- Steroid hormone receptor family member cnr14
- Signal element on autosome protein 2
- Sex determination protein fox-1
- Nuclear hormone receptor family member nhr-2
- C2H2-type domain-containing protein
Sequence:
MDFSNTYRNYGEVVDFPEDFLSDYVPTVKSEPEPAAIAPSVCEPPISTTRNYGTDFGRASSMCGSSSSSSSSSYSSGSSPNYLTENGGDTEEPRFEELVSRKMSFDSENVAQVSNQMDYARDTYADSRIPFASIDSNDALLPYPVNNYVAALPVPVPAKKSRGRTAPRTPKSLETSKPGRGVKRPASKEIDAKDLGIGDLSAHMNRQIGDDEELDTQLIAHRILDELKEQCIPQASLAVKVLGRSQGTLSDLLRKPKPWGIMKNGRGTFQRMANWLDLDPVVRRALCFMKKEDVARITGMAEPTPAKRARQTTPSDERIRRFTFTQTQLDSLHTVFQQQDRPNREMQQALSATLKLNRSTVGNFFMNARRRLPKAAPVSQNLVAEHAIDHNQPGPSHHY
Protein: Myogenic factor (Q9DDW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDVFSTSQIFYDSTCASSPEDLEFGASGELTGSEEDEHVRAPGAPHQPGHCLQWACKACKRKASTVDRRRAATMRERRRLKKVNHAFEALRRCTSANPSQRLPKVEILRNAIQYIESLQELLREQVEQYYSLPMESSSEPASPSSSCSESMVDCNSPVWPQMNQNYGNSYNFDAQNASTMERTPGVSSLQCLSSIVDRLSSVDPAGMRNMVVLSPTGSDSQSSSPDSPNNRPVYHVL
Protein: Voltage-gated calcium channel alpha 1A subunit (Q704P2)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
KGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYDKNEVKAKDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSILYVVYCVVFPFFFVNILVALIIITFQEQGDKMMEEYSLEKNERACIDFAISVKPLTRHIPQNKQSYQYRMWQFVVSPPIEYTIMAMIALNTIVLMMKFYGASVALRMLMRVFNIVFTSLFSL
Protein: Protein transport protein sec39 (O14266)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MNEDKLESKWLFSLTESQKLYLLISLIINKKLPEAKFVYKLLDYTKGNWLSLLLRFLPETTDPECYIPYIDIDSHYGNIKASVNDIEPIVLPDEELCQLRLTNMKLWNCKLPSLKDEAEFYSLFSKKIVEETDLVDLAYQLTKNSQAPAEIQQWNSGTFTVFHKLSQFAAVPINLEEMEAATIRDVISLAFPVLDSKNCVFIMDEIITVFINNSSNDPNLISENWDFVWKKLLQLVKTDGLAVVHTLVLNWNTIEPKLFLKLAKVALASCYISDDSSLYSVSLARDITEAIQNKLNFSDVNFGDLLKKPHDFSADGLLSLQNDLTTPSSLSTSLLMEITKAIALLTQLKVPAPTFKTSVSISCSNFDSQIKYLENVLLNALGTIQSPDYKDWHDLYSYIERFKQLSLFFLNISEDAISVVFLKQMLQEKSFLALKQMRNEIGLKDIEPKVLIDCLKTSFYENFRAASNMNKNRGKLALACKVLDVFVDCEPTIDLRRRLNSLVNACSLIQPFKLILEPGKPLSPSLVEANLNPDKLIKTIFSQNPSAYTLYDDILALDIELHKAAGDFDYSQVFTELRRITEHMITLTIDVSLEKDDIEYAKQIVEDRLMTLAEASEDVKFFLYEIAYKIGKFPSNHPNAKVIRLDMLQIAIANAPRQKLDEVVSYWTDFQSNSKVLEENLNTTDVEFHSSKKIKDYEDLEDANFDEEWSKAADLMSDDPENQVLYEGNLNSSLSLNEDPSVSDENLTQKVTSKLTNGLGWVLGVPPRK
Protein: Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] (O54824)
Organism: Mus musculus (Mouse)
Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Subcellular location: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:10479680}. Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
- T-cell surface glycoprotein CD4
- Caspase-3
- Interleukin-10
- Interleukin-1 alpha
Sequence:
MEPHGHSGKSRKSTKFRSISRSLILCNAKTSDDGSSPDEKYPDPFETSLCQGKEGFFHSSMQLADTFEAGLSNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSGKPEAQSSSFLFPKACHQRTRSNSTSVNPYSAGEIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYPILGTARPTRSLSTAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVEGVKFGKDRHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSSSDSSYMSGSPGGSPCSAGAEPQPSEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRLKKSFEILVRKPTSSKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHTLPTCSQETRELLPLLLQEDTAGRAPCTAACCPGPAASTQTSSSTEGESRRSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMSENHSHTPLQPNTSLGEEDGTQGCPEGGLSKMDAANGAPRVYKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRAPDPRRPPEVASAIQPTPVSRDPPGPQPQASSSIRQRISSFENFGSSQLPDRGVQRLSLQPSSGETTKFPGKQDGGRFSGLLGQGATVTAKHRQTEVESMSTTFPNSSEVRDPGLPESPPPGQRPSTKALSPDPLLRLLTTQSEDTQGPGLKMPSQRARSFPLTRTQSCETKLLDEKASKLYSISSQLSSAVMKSLLCLPSSVSCGQITCIPKERVSPKSPCNNSSAAEGFGEAMASDTGFSLNLSELREYSEGLTEPGETEDRNHCSSQAGQSVISLLSAEELEKLIEEVRVLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGATHNDALAILRQARDPRQAVIVTRRTTVEATHDLNSSTDSAASASAASDISVESKEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKGTEQGEMVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTIVIRRTSLQCKQTTASADS
Protein: DDB1 and CUL4 associated factor 13 (E5RHM4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIEVMFFFKYVLLIMA
Protein: Amidase 1 (AtAMI1) (EC 3.5.1.4) (Translocon at the outer membrane of chloroplasts 64-I) (AtTOC64-I) (Q9FR37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Amidase involved in auxin biosynthesis. Converts indole-3-acetamide to indole-3-acetate. Converts phenyl-2-acetamide (PAM) to phenyl-2-acetate. Substrate preference is PAM > IAM. Can also use L-asparagine and 1-naphtalene-acetamide as substrates, but not indole-3-acetonitrile or indole-3-acetyl-L-aspartic acid.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12620340, ECO:0000269|PubMed:14741350, ECO:0000269|PubMed:16738862, ECO:0000269|PubMed:27135507}. Nucleus, nucleoplasm {ECO:0000269|PubMed:27135507}.
Interaction partners:
- Glutamyl-tRNA
- Nitrilase 1
- Nitrilase 3
- Nitrilase 2
- Indole-3-acetaldehyde oxidase
- Probable amidase At4g34880
- Aldehyde dehydrogenase family 2 member B4, mitochondrial
- Aldehyde dehydrogenase family 3 member H1
- Aldehyde dehydrogenase family 2 member B7, mitochondrial
- Aldehyde dehydrogenase family 7 member B4
Sequence:
MATNNDFGAFIEKVTISPTSTSSSPPSLQGLTFAIKDIFDVEGRVTGFGNPDWLRTHSAATSTAPVVSSLLEAGATALGITIMDEMAYSINGENAHYGTPRNPIAFDRVPGGSSSGSAVAVAARLVDFSIGTDTGGSVRVPASYCGIFGFRPSHGAVSTVGLTPMAQSFDTVGWFARDTATLKRVGCVLLQQHHLNPIEPSQLIIADDCFKLCSVPHDLLVQPLVGSVEKSFGGNTVVKKVNLGEYIGQNVPSLKHFMTSDDVTTQQEFCIPSLMALSSSMRLLQRHEFKINHGAWISSVKPEFGPGISERIEEAIRTSDEKIDHCRSVKSELITALSTLLGEKGVLVIPTVPGPPPHLQANVAALESFRSRAFSLLSIAGVSGFCQVSIPLGLHENLPVSVSLVAKYGSDGFLLSLVDSLAAFI
Protein: Peptidoglycan glycosyltransferase MrdB (PGT) (EC 2.4.99.28) (Cell elongation protein RodA) (Cell wall polymerase) (Peptidoglycan polymerase) (PG polymerase) (Rod shape-determining protein) (Shape, elongation, division and sporulation glycosyltransferase RodA) (SEDS GT RodA) (P0ABG7)
Organism: Escherichia coli (strain K12)
Function: Peptidoglycan polymerase that is essential for cell wall elongation. Also required for the maintenance of the rod cell shape. Functions probably in conjunction with the penicillin-binding protein 2 (mrdA).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02079, ECO:0000269|PubMed:6348029, ECO:0000305|PubMed:37620344}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02079, ECO:0000305|PubMed:37620344}.
Interaction partners:
- Peptidoglycan D,D-transpeptidase MrdA
- Rod shape-determining protein MreD
- Cell shape-determining protein MreC
- Cytoskeleton protein RodZ
- Penicillin-binding protein 1A
- Cell shape-determining protein MreB
- Peptidoglycan D,D-transpeptidase FtsI
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Penicillin-binding protein 1B
- Lipid II flippase MurJ
Sequence:
MTDNPNKKTFWDKVHLDPTMLLILLALLVYSALVIWSASGQDIGMMERKIGQIAMGLVIMVVMAQIPPRVYEGWAPYLYIICIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAVPLMVARFINRDVCPPSLKNTGIALVLIFMPTLLVAAQPDLGTSILVALSGLFVLFLSGLSWRLIGVAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPESDPLGAGYHIIQSKIAIGSGGLRGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLVGILILLALYILLIMRGLWIAARAQTTFGRVMAGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSV
Protein: Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] (P21177)
Organism: Escherichia coli (strain K12)
Function: Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
Interaction partners:
- 3-ketoacyl-CoA thiolase FadI
- Acetyl-CoA acetyltransferase
- 3-ketoacyl-CoA thiolase FadA
- Acyl-coenzyme A dehydrogenase
- Probable acetyl-CoA acetyltransferase
- Fatty acid oxidation complex subunit alpha
- Acetyl-coenzyme A synthetase
- 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase
- Acetate CoA-transferase subunit beta
- Long-chain-fatty-acid--CoA ligase
Sequence:
MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLVDGVVKAEKLVEGAKAVLRQAINGDLDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDVETPKQAAVLGAGIMGGGIAYQSAWKGVPVVMKDINDKSLTLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDIVVEAVVENPKVKKAVLAETEQKVRQDTVLASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDANRFGQKNGLGFWRYKEDSKGKPKKEEDAAVEDLLAEVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALVYGLGFPPFHGGAFRWLDTLGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGDLKTA
Protein: AT3g50910/F18B3_190 (Netrin receptor DCC) (Q94BX2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable glucan endo-1,3-beta-glucosidase BG1
- GDP-mannose 4,6 dehydratase 2
- Probable boron transporter 7
- Probable boron transporter 6
- Galactinol synthase 3
- Beta-D-glucopyranosyl abscisate beta-glucosidase
- Probable boron transporter 2
- Fucosyltransferase
Sequence:
MPTFSAIALDRMLEPGASTSVESVPSTTNLFYSKPPISKLEKGKGKLPNERTVTRPLMSPALYATPDAIPLPNSPSSFPPSPYIINHKSRGPPRLLKSSSEANVVSSSHQKTLEEETITAETDVKVSPRRRSTSFSFPITEVTEDDYSNGVHARTVGNYNFDGIVDGPVGNWSPLDGKSGNGKSELDNAANGLERVNGLSEPVPIKTDKESESEDFYDPGESASFTSNTDVEGDAGDESSQRLATPVGEFYDAWDELSTDSGMQSSVNNIESELSEIRLSLLMEIEKRKQTEEALEQMQIHWQRLREQMAQVGLFVPIDPTASTNNMNLSEELRCQLEIARFVSDSLGRGMAKAEVEMEMESMLETKNFEITRLSDRLHYYEAVNREMSQRNQEAIEVARRERQKRKKRQRWIWGSIAATITLGSAALAWSYIPAAKPSSEVSLKDE
Protein: Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Q9Y6I4)
Organism: Homo sapiens (Human)
Function: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:37971847}. Cytoplasm {ECO:0000269|PubMed:37971847}. Note=Localizes preferentially with monoubiquitinated H2A to chromatin (PubMed:17980597). Upon NF-kappa-B signaling activation, exits the nucleus (PubMed:37971847). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:37971847}.
Interaction partners:
- Polyubiquitin-C
- Histone H2A type 2-A
- Histone H2A type 2-C
- Histone H2B type 2-E
- Transformation/transcription domain-associated protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Transcription initiation factor TFIID subunit 10
- Antiviral innate immune response receptor RIG-I
- Ubiquitin-ribosomal protein eL40 fusion protein
- Transcriptional adapter 3
Sequence:
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL
Protein: Defensin-like protein A (AhSCRA) (S locus cysteine-rich-like protein SCR04) (AhSCR04) (Q19MC2)
Organism: Arabidopsis halleri subsp. gemmifera (Arabis gemmifera)
Function: Involved in male-mediated self-incompatibility.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MRCVVLFMVSCLLIVLLINHFEEVEAQKWKECNLRDIFPGKCEHDANAKLRCKEDIAKNFRPSRPFECDCQTFDQGRICYCKKCLV
Protein: F-box C protein (O17100)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNSSKPLSYPSIGSILQHLKPDKKFQLSQQCRTITSIDKSRPLYLKSLKLNENSIKLNGTTYELNVIENSLKPRAFPYDVNSQGSIDLEMVVPDQEQEQEILVDDRTDNPTSYNEQRISRADLKNAPSSSYTHYIRFSVGNHSEQLQYNERKLHDAMKYLIDKLLGGRPTIKARQFCVENSGILRIPRHLKIRAKVVQLNGLIREKLLNATQHLLDIKSLPLSGVIISDPLMNAPNLDIDFIQTAEMLLLYCEVISGEGLLKVRHKRVYINAYLYDATFRLFEDWMEHGREVGTHFSFAMRNEGNIIDVLDKIRINYNVEEGTAENQLTIHINNFTDIVVSHKVDTWILEYKVQQREVM
Protein: G1/S-specific cyclin-E1 (P39949)
Organism: Rattus norvegicus (Rat)
Function: Essential for the control of the cell cycle at the G1/S (start) transition.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P24864}.
Interaction partners:
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase 4
- cyclin-dependent kinase
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1
- S-phase kinase-associated protein 1
- Cyclin-dependent kinase inhibitor 1C
- F-box/WD repeat-containing protein 7
- Retinoblastoma-associated protein
- S-phase kinase-associated protein 2
Sequence:
MPRERKERDSKDHTKMKEEGGSDLSVRSRKRKPNVPVFLQDPDEEIAKIDKTVKSQDSSQPWDDDSACVDPCSFIPTPNKEEDNELEYPKTAFQPRKIRPPRASPLPVLNWANREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLSPLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWCDIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMEDSHNIQTHTNSLDLLDKAQAKKAILSEQNRISPPPSGVLTPPHSSKKQSSEQETE