wanglab/gogpt-training-data huggingface dataset:
Protein: Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1a) (Estrogen synthase) (O42145)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Subcellular location: Membrane; Peripheral membrane protein.
Interaction partners:
- Forkhead box protein L2
- Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Estradiol 17-beta-dehydrogenase 1
- 17-beta-hydroxysteroid dehydrogenase type 3
- Estrogen receptor
- Anti-Mullerian hormone
- Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
- Doublesex- and mab-3-related transcription factor 1
- Very-long-chain 3-oxoacyl-CoA reductase-A
- Hydroxysteroid
Sequence:
MAGDLLQPCGMKPVRLGEAVVDLLIQRAHNGTERAQDNACGATATILLLLLCLLLAIRHHRPHKSHIPGPSFFFGLGPVVSYCRFIWSGIGTASNYYNSKYGDIVRVWINGEETLILSRSSAVYHVLRKSLYTSRFGSKLGLQCIGMHEQGIIFNSNVALWKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQLTDAQGQLDILNLLRCIVVDVSNRLFLGVPLNEHDLLQKIHKYFDTWQTVLIKPDVYFRLDWLHRKHKRDAQELQDAITALIEQKKVQLAHAEKLDHLDFTAELIFAQSHGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVLAGQSLQHSHLSKLQILESFINESLRFHPVVDFTMRRALDDDVIEGYNVKKGTNIILNVGRMHRSEFFSKPNQFSLDNFHKNVPSRFFQPFGSGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACTVENIPQTNNLSQQPVEEPSSLSV
Protein: Cyclic nucleotide gated channel subunit alpha 3 (A0A0G2K054)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MHQMETSTMVQDNRVSRFIISIRAWAARHLHHEDPTPDSFLDRFHGAELKEVSSQERNAQPNPGGQEPPEGGKGRKKDPIVVDPSSNIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADALYVVDMLVRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGMNYPELRFNRLLRFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEYPDAKRALEEKGRQILMKDNLIDDDLVTARADARNIEEKVEYLESSLDGLQTRFARLLAEYSASQMKLKQRLSQLESQMTRRGHGFSPDRENSEDASKAD
Protein: Alpha-1,4-N-acetylglucosaminyltransferase (Alpha4GnT) (EC 2.4.1.-) (Q9UNA3)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct. May protect against inflammation-associated gastric adenocarcinomas (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Mucin-6
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
Sequence:
MRKELQLSLSVTLLLVCGFLYQFTLKSSCLFCLPSFKSHQGLEALLSHRRGIVFLETSERMEPPHLVSCSVESAAKIYPEWPVVFFMKGLTDSTPMPSNSTYPAFSFLSAIDNVFLFPLDMKRLLEDTPLFSWYNQINASAERNWLHISSDASRLAIIWKYGGIYMDTDVISIRPIPEENFLAAQASRYSSNGIFGFLPHHPFLWECMENFVEHYNSAIWGNQGPELMTRMLRVWCKLEDFQEVSDLRCLNISFLHPQRFYPISYREWRRYYEVWDTEPSFNVSYALHLWNHMNQEGRAVIRGSNTLVENLYRKHCPRTYRDLIKGPEGSVTGELGPGNK
Protein: Nuclease SbcCD subunit D (P0AG76)
Organism: Escherichia coli (strain K12)
Function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Interaction partners:
- Nuclease SbcCD subunit C
- DNA polymerase I
- ATP-dependent DNA helicase RecQ
- Flap endonuclease Xni
- Protein RecA
- DNA mismatch repair protein MutL
- Exodeoxyribonuclease I
- Single-stranded-DNA-specific exonuclease RecJ
- UvrABC system protein A
- UvrABC system protein B
Sequence:
MRILHTSDWHLGQNFYSKSREAEHQAFLDWLLETAQTHQVDAIIVAGDVFDTGSPPSYARTLYNRFVVNLQQTGCHLVVLAGNHDSVATLNESRDIMAFLNTTVVASAGHAPQILPRRDGTPGAVLCPIPFLRPRDIITSQAGLNGIEKQQHLLAAITDYYQQHYADACKLRGDQPLPIIATGHLTTVGASKSDAVRDIYIGTLDAFPAQNFPPADYIALGHIHRAQIIGGMEHVRYCGSPIPLSFDECGKSKYVHLVTFSNGKLESVENLNVPVTQPMAVLKGDLASITAQLEQWRDVSQEPPVWLDIEITTDEYLHDIQRKIQALTESLPVEVLLVRRSREQRERVLASQQRETLSELSVEEVFNRRLALEELDESQQQRLQHLFTTTLHTLAGEHEA
Protein: G domain-containing protein (Q38DB9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWWSVRLFQRGTAAGPTAMTAASPLTESCATQQVTTKNVRRPSKLQRQMFMDRMKKRHRARVKMIAAQEQSHLATVRSSNLNGRDVIMAQLADEIFSRGHKHVCCATNISFVPDGNPAMPEVALAGRGQCGKSSLLRSLFRSSREVGRSNVKLRRDAMNFFNVGGGVFNIVDLPGFGGTSVPWSTLLQHAVLLRNFVRCRPNLKMLYYCMDVHYRHGVYIQDLDLLRFLSKEVPNFTIVVTKGDQLDTTKSRNVFRLEDIRKELLFHDITHPVLVTSAYHMGGVDALRFDMVMNCLHALPTERLTITEAKRLSERLLTQREIGTVRHLPLAPTQLQDELRNWSEEVEKERAIEPVTPGSMEQKHEGESAHGLSERDTNTSGCSRGKCTSKAVAVEVGSSVTPADISLALDQAEAFTSLKKKVTNEGLMKYVRQTSPWRNPLLWPENVVPTKHPKANIMRCPEDPHNPYLTQAHFVCPRADMYFRRPNVGTRKGVEKGRYEADRPLAFLLKPYTIPYFPDVVDVKMHPLPWTFLGSREAYYESTGGRQLGVRMAQYVTNGEIRALNDNPAPTQPDLTKELQKLERKRYGSSIAMLRPPGKQVKGLTTGMPSVLIHGSECVDQVTAAPPQPLGAGK
Protein: Intron-encoded DNA endonuclease aI3 (DNA endonuclease I-SceIII) [Cleaved into: Truncated non-functional cytochrome oxidase 1; DNA endonuclease aI3 (EC 3.1.-.-) (Intron-encoded endonuclease I-SceIII)] (P03877)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with high specificity and cleaves the sequence 5'-GGTTTTGGTAACTATTTATTAC-3'.
Subcellular location: Mitochondrion. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Intron-encoded DNA endonuclease aI4
- Intron-encoded DNA endonuclease aI5 alpha
- Cytochrome c oxidase subunit 1
- Putative COX1/OXI3 intron 1 protein
- Cytochrome c oxidase subunit 3
- Intron-encoded DNA endonuclease aI5 beta
- Cytochrome b mRNA maturase bI2
- Putative COX1/OXI3 intron 2 protein
- Cytochrome b
- Cytochrome c oxidase subunit 2
Sequence:
MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNQKRYESNNNNNQVMENKEYNLKLNYDKLGPYLAGLIEGDGTITVQNSSSMKKSKYRPLIVVVFKLEDLELANYLCNLTKCGKVYKKINRNYVLWTIHDLKGVYTLLNIINGYMRTPKYEAFVRGAEFMNNYINSTTITHNKLKNMDNIKIKPLDTSDIGSNAWLAGMTDADGNFSINLMNGKNRSSRAMPYYCLELRQNYQKNSNNNNINFSYFYIMSAIATYFNVNLYSRERNLNLLVSTNNTYKTYYSYKVMVANTYKNIKVMEYFNKYSLLSSKHLDFLDWSKLVILINNEGQSMKTNGSWELGMNLRKDYNKTRTTFTWSHLKNTYLENK
Protein: Hydrogenase expression/formation protein HypD (Q72F89)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Hydrogenase expression/formation protein HypE
- Hydrogenase assembly chaperone hypC/hupF
- Hydrogenase accessory protein HypB
- Carbamoyltransferase
- Hydrogenase maturation factor HypA 2
- Periplasmic [NiFe] hydrogenase large subunit
- Periplasmic [NiFe] hydrogenase large subunit
- Hydrogenase maturation factor HypA 1
- Periplasmic [NiFe] hydrogenase large subunit
Sequence:
MSVDFTSSFKDPALCRGLLDRLHRELDRPLRFMEVCGTHTVAIFQSGIRPLLPEGVRHLSGPGCPVCVTHESEVAAYLQLAERGDVIIATFGDLMRVPGPGGRNLKLAQAQGARIEVVYSSFDALKLAADNPGEKVVFLGIGFETTAPTVAGTVQMARAQGLDNFMVLSFHKLVPPALRALLVDPECAVDAFLLPGHVSTVLGIEPYRFVATEFGTPGVIAGFDPVDILQALLIMVEQRKTGEYGIVNAYRRAVDDAGNPRARQVMDDVFMQSDALWRGIGLLPGSGLVFRPEYARFDAMQRLGLTLPEARDTPGCKCGDVLKGKMQPNECPLFGKACVPAKPVGPCMVSTEGSCAAYYKYNVEA
Protein: Uncharacterized protein (Q586T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKGGGGIVCFSQECLYFPSPLTDASIENIIELSSLLVRTEDPCENVVAFKVLSAVRNRYGVQPSVGLIFAGECVRVKFMLDIRRLRRLAARRGGVEEGAVELPDAGTRDEVFVDICVVPREVMAPYESVSGFFGGDCSRKGPSGPDVAAAFWKQRGRVQARERNAVRCALRCIYGELGVPDSLVMKRSHGKVEGLVEGCETAAVEKAPAAQPQLGSAVRNAGGEVSPPSTALRSRHSPKGAGDQTAASASPLVYSPVNCASGTVPSGRCSNGYEAAVGEASRMTNVIAPDSGREMYSLLSVFLLYKVPFPVCCILLFLSFLCGIIE
Protein: Phenylalanine ammonia-lyase (EC 4.3.1.24) (Q3M5Z3)
Organism: Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
Function: Catalyzes the non-oxidative deamination of L-phenylalanine to form trans-cinnamic acid, the first step in the phenylpropanoid pathway.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Histidinol-phosphate aminotransferase 2
- Histidinol-phosphate aminotransferase 1
- Aminotransferase
- Prephenate dehydratase
- Arginase/agmatinase/formiminoglutamase
- Imidazoleglycerol-phosphate dehydratase
- Terpene synthase
- Transaldolase
- Transaldolase
Sequence:
MKTLSQAQSKTSSQQFSFTGNSSANVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIYGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGASGDLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARACLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDILPCLH
Protein: ETS-related transcription factor Elf-1 (E74-like factor 1) (P32519)
Organism: Homo sapiens (Human)
Function: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDMITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRINNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYINDEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQTVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLGPAQVQQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPGTVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSNGFTSQVAMKQNELLEPNSF
Protein: GTP-binding nuclear protein Ran (Q96QB7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363057}.
Interaction partners:
Sequence:
MAAQGQPQVQFKLVLVGDGGTGKTTFVKHHLTGEFEKKYVATLGVEVHPLVFHTNRGPVKFNVWDTAGLEKFSGLRDGYYIQAQSTIIVFDVTSRVTYKNVPNWHRDLV
Protein: Krueppel-like factor 2 (Lung krueppel-like factor) (Q60843)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor p65
- Nuclear factor NF-kappa-B p105 subunit
- Homeobox protein NANOG
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- Sphingosine 1-phosphate receptor 1
- Steroid hormone receptor ERR2
- C-C chemokine receptor type 7
Sequence:
MALSEPILPSFATFASPCERGLQERWPRNEPEAGGTDEDLNNVLDFILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYSIPAASLGTELLRPDLDPPQGPALHGRFLLAPPGRLVKAEPPEVDGGGYGCAPGLAHGPRGLKLEGAPGATGACMRGPAGRPPPPPDTPPLSPDGPLRIPASGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAFGLFEDAAAAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYTNCGKTYTKSSHLKAHLRTHTGEKPYHCNWEGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM
Protein: RNA helicase (EC 3.6.4.13) (A0A2U3TZJ9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASRRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
Protein: Transcription factor RLM1 (Q12224)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May function as a transcription factor downstream of MPK1 that is subject to activation by the MPK1 mitogen-activated protein kinase pathway. Binds to the DNA sequence 5'-CTA[TA](4)TAG-3'. At least some RML1 target genes are involved in cell wall biosynthesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Mitogen-activated protein kinase SLT2/MPK1
- Serine/threonine-protein kinase KDX1
- Regulatory protein SWI4
- Dual-specificity protein phosphatase SDP1
- Mitogen-activated protein kinase HOG1
- Protein kinase C-like 1
- MAP kinase kinase MKK1/SSP32
- 1,3-beta-glucan synthase component FKS1
- Serine/threonine-protein kinase BCK1/SLK1/SSP31
- Regulatory protein SWI6
Sequence:
MGRRKIEIQRISDDRNRAVTFIKRKAGLFKKAHELSVLCQVDIAVIILGSNNTFYEFSSVDTNDLIYHYQNDKNLLHEVKDPSDYGDFHKSASVNINQDLLRSSMSNKPSKSNVKGMNQSENDDDENNDEDDDDHGNFERNSNMHSNKKASDKNIPSAHMKLLSPTALISKMDGSEQNKRHPENALPPLQHLKRLKPDPLQISRTPQQQQQQNISRPYHSSMYNLNQPSSSSSSPSTMDFPKLPSFQNSSFNGRPPPISISPNKFSKPFTNASSRTPKQEHKINNSGSNNNDNSNYTQSPSNSLEDSIQQTVKARRKLSARPVLRVRIPNNNFSSNSAIPSEPSSASSTSANGNSMGSSQIMKENKTSRSSKISPLSASASGPLTLQKGNNGRMVIKLPNANAPNGSNNGNGSNNNNHPYPFGSGSSPLFSATQPYIATPLQPSNIPGGPFQQNTSFLAQRQTQQYQQMSFKKQSQTVPLTTTLTGRPPSTFSGPETSNGPPTGSLPSKFVHDLMSNSPNVSSISMFPDWSMGPNSAKPGNTNNPGTFPPVQTAVNNGNSSNISSTNNTNNNNNNNNNNSSNNNSNNGNDNNSNNSNNSYYSNNEDAPVNGAAISEHTTDGDSNNQSNSSTYDAAATAYNGNTGLTPYINTAQTPLGTKFFNFSTDISGEKNSSKI
Protein: Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) (O43353)
Organism: Homo sapiens (Human)
Function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Also plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21887730}. Cell membrane {ECO:0000269|PubMed:17355968}; Peripheral membrane protein {ECO:0000305|PubMed:17355968}. Endoplasmic reticulum {ECO:0000269|PubMed:28656966}. Note=Recruited to the cell membrane by NOD2 following stimulation by bacterial peptidoglycans. {ECO:0000269|PubMed:17355968}.
Interaction partners:
- E3 ubiquitin-protein ligase XIAP
- Nucleotide-binding oligomerization domain-containing protein 1
- Nucleotide-binding oligomerization domain-containing protein 2
- Caspase recruitment domain-containing protein 6
- TNF receptor-associated factor 3
- TNF receptor-associated factor 6
- Baculoviral IAP repeat-containing protein 2
- Tumor necrosis factor receptor superfamily member 16
- NF-kappa-B essential modulator
- TNF receptor-associated factor 2
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (P73037)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Heat shock protein
- Peptidyl-prolyl cis-trans isomerase slr1251
- Putative thylakoid lumen peptidyl-prolyl cis-trans isomerase sll0408
- Circadian input-output histidine kinase CikA
- UmuC protein
- Slr0157 protein
- Translation initiation factor IF-1
- Regulatory components of sensory transduction system
Sequence:
MRGRTHGIIRPTLLRPIFLMKFFTAMRDILISLTVVTFFSLVLISVAIFGKSSPSAIAAPQEVKPVQIAQASALQTPEPSPMTAENSANIVTTESGLQYIDEVVGEGPSPTKGQKVEVHYTGRLTDGTKFDSSVDRNKPFTFTIGVGQVIKGWDEGVATMQVGGKRKLIIPPDLAYGSRGAGGVIPPNATLEFEVELLGIK
Protein: Sulfotransferase (Q57UM1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Adrenodoxin reductase, putative
- NB-ARC domain-containing protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase complex I subunit
- NADH dehydrogenase subunit NI8M
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Peptidyl-prolyl cis-trans isomerase
- NADH-ubiquinone oxidoreductase complex I subunit
- Uncharacterized protein
Sequence:
MFLKKTMSGVRDLSRGRPISRVILDRFAGSISSESFSFESVLEDACRRANVAVSAAPSSIADIKWWRKLCTACGNKTSASRCGLAMLRQRLVRALSERLATEEVFRLNGYEIGKEIVDEPVVVLGLPRCNGHQAAHVLSRSGVFLAFKQCDTISPSLLLDVERHDAFQREFRWFKSLYPDFCCVRTVNPGQIDDDLTLQLMCPQSYAWGLLHGLDEYLLECLQEDQTPVYEHIKRMCQLFQWYKRCGHFSECVSQEVNPINNVIEEQKYGTKNPLTRTRWLIFSPLALLSIESLCEVFPDVKIIWVHRALSQCIPSLCSALALHNSLYTGKPPSDTQLVTMGDKVLGMFGSGTEHAIDFLASFEKSRMVHWSNRDLKRHTTRLATKTLQHYGIEVDRYRKMQMINGQTEYTEVFRPLHDSQMRYFGLHDGIIGEVFERYIYQFEEFAFERKYGVTVEEYQPLAAASEQQSLGSMRVNSGENSLPSFTDDQPMTGHFLQEGKGFK
Protein: Protein Rv2204c (P9WMN5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible nitrogen fixation related protein
- IscS-like cysteine desulfurase
- Uncharacterized protein Rv0883c
- Uncharacterized protein Rv2205c
- Glutaredoxin-like protein NrdH
- Dihydroorotate dehydrogenase
- Uncharacterized protein Rv2206
Sequence:
MTVQNEPSAKTHGVILTEAAAAKAKSLLDQEGRDDLALRIAVQPGGCAGLRYNLFFDDRTLDGDQTAEFGGVRLIVDRMSAPYVEGASIDFVDTIEKQGFTIDNPNATGSCACGDSFN
Protein: Myosin ID heavy chain (P34109)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin id may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the process of phagocytosis.
Subcellular location: Cell projection, pseudopodium. Cytoplasm, cell cortex. Note=Highest concentration just beneath the plasma membrane in the anterior pseudopod at the leading edge of the cell.
Interaction partners:
- Myosin-IB light chain
- Myosin IB heavy chain
Sequence:
MAYKSQHGVDDMVMLSKIANDSILDNLKKRYGGDVIYTYIGNVLISVNPFKQIKNLYSERNLLEYRGKFRYELPPHAYAVADDMYRSMYAEGQSQCVIISGESGAGKTEAAKLIMQYIAAVSGKGADVSRVKDVILESNPLLEAFGNAKTLRNNNSSRFGKYMEVQFNGIGDPEGGRVTNYLLEKSRVVYQTKGERNFHIFYQLLSGANQQLKSELRLDTPDKFNYLSASGCYTVDGVDDSGEFQDVCKAMKVIGLTDSEQKEVFRLVAAILYLGNVGFKNNAKDEAAIDQQSKKALENFAFLMQTDVSSCEKALCFRTISTGTQGRSARVSTYACPQNSEGAYYSRDALAKALYSRLFDWIVGRVNSALGYKQNSQSLMIGILDIYGFEIFEKNGFEQMVINYVNERLQQIFIELTLKTEQEEYFNEGIQWEQIDYFNNKICCDLIESKKPAGILTILDDVCNFPKGDDQKFLDRLKESFSSHAHFQSAAQSSSSFTIKHYAGDVEYCAEGFVDKNKDLLFNDLVELAACTTSKLIPQLFPEINCEKDKRKPTTAGFKIKESIGALVKALSACTPHYIRCIKPNGNKRANDFDTSLVMHQVKYLGLLENVRIRRAGYAYRQTYDKFFYRYRVCCKETWPNWTGGFESGVETILKSMDLEPKQYSKGKTKIFIRAPETVFNLEELRERKVFTYANKLQRFFLRFTLMSYYYSIQKGAADSMKSNKERRRLSIERPYQGDYINYRENFELKDIVKKNGNEKIMFTHAVNKYDRRSRCQRRVLLLSDTAIYFIATEKNKDKEDRKKRPWIYVQKRRLLLAGITSVELSKLSDGFVVLKTMNEHDQIFECRRKTEFLGTLIKAYKTGTLRINYNNSIGVAIKASKQGGKGKERIILFEKGIKPGESVFKGTKVSTPSDGLPADTVPNLTPPESLPVVSIPIYKPAMNAKNAPQNSGGPASNVKPSAKALYDFDAESSMELSFKEGDILTVLDQSSGDWWDAELKGRRGKVPSNYLQLIKNAAPPRAGGPPVPTGNRAPTTTTTSGGSTRGGFNNGPSTAPSGRGAAPPSSRGGMAPRGGSVAPPSSRGGIAPRGGIAPRGGMAPRGGMAPRV
Protein: Uncharacterized protein C1orf50 (Q9BV19)
Organism: Homo sapiens (Human)
Interaction partners:
- Adenosylhomocysteinase
Sequence:
MEDAAAPGRTEGVLERQGAPPAAGQGGALVELTPTPGGLALVSPYHTHRAGDPLDLVALAEQVQKADEFIRANATNKLTVIAEQIQHLQEQARKVLEDAHRDANLHHVACNIVKKPGNIYYLYKRESGQQYFSIISPKEWGTSCPHDFLGAYKLQHDLSWTPYEDIEKQDAKISMMDTLLSQSVALPPCTEPNFQGLTH
Protein: SR-CI (Q5ELS8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSIDLDNGSINYRQRNIVRFRCNRGYTLQGTVMQTCDRDGRLRGEKPFCASRGCARPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFTTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSVPPTVTSTSTSTTRKSTTPTTTSTTTTSTTTTKRPTTAATTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTTMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSESTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLKKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: Lysine-rich coiled-coil protein 1 (Cryptogenic hepatitis-binding protein 2) (Q9NPI7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKHSKKTYDSFQDELEDYIKVQKARGLEPKTCFRKMKGDYLETCGYKGEVNSRPTYRMFDQRLPSETIQTYPRSCNIPQTVENRLPQWLPAHDSRLRLDSLSYCQFTRDCFSEKPVPLNFNQQEYICGSHGVEHRVYKHFSSDNSTSTHQASHKQIHQKRKRHPEEGREKSEEERSKHKRKKSCEEIDLDKHKSIQRKKTEVEIETVHVSTEKLKNRKEKKSRDVVSKKEERKRTKKKKEQGQERTEEEMLWDQSILGF
Protein: Syntaxin-8A (Q553P5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:12175335}; Single-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:12175335}.
Interaction partners:
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-7A
- Vesicle-associated membrane protein 7A
- Alpha-soluble NSF attachment protein
- t-SNARE family protein
- Vesicle-associated membrane protein 7B
- Vesicle-trafficking protein SEC22b
- t-SNARE family protein
- t-SNARE family protein
- V-SNARE family protein
Sequence:
MNNNNNFNSNFNSNRISSTQPYLSDDARNALFEGKDRKWGNNNNNNYDTLSNQDVFEKQKRDMEEQDKMLDALSGSISRVKDTAITINKTAQEQTDMLDELDVHVDSTSARMRNTTKNLITLTQQSKTTGYCSAICFLLLVLLVIIILASVL