wanglab/gogpt-training-data huggingface dataset:
Protein: Protein unc-45 homolog A (Unc-45 homolog A (C. elegans)) (Unc-45 myosin chaperone A) (Q567I0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSQDSSALREEGNNHFKAGDVQQALTCYTKALKISDCPSESAVLYRNRSACYLKLEDYTKAEEDATKSLDVDPGDIKARFRRAQALQKLGRLDQAFMDVQKCAQLEPKNKAFQDLLRQLGAQIQQKATQLSSTDSRVQQMFKLLLDSSAPIADRQKAAQNLVVLSREDAGAEQIFRNDGVKLLQNLLESKQEELILSALRTLVGLCTGHQSRTEFGHP
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (P39656)
Organism: Homo sapiens (Human)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29381}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29381}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
- Protein transport protein Sec61 subunit alpha isoform 1
Sequence:
MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
Protein: Ventral anterior homeobox 1 (Q2NKI2)
Organism: Mus musculus (Mouse)
Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Interferon regulatory factor 6
- Homeobox protein SIX3
Sequence:
MFGKPDKMDVRCHSDTEAARVSKNAHKESREIKGAEGSLPAAFLKEPQGAFSGSGASEDCNKSKSNSSADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLRLLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAAATAPGPAGAASQHQPAVGGAPGPGPAGPGGLHAGAPTASHGLFSLPVPSLLGSVASRLSSAPLTMAGSLAGNLQELSARYLSSSAFEPYSRTNNKEGAEKKALD
Protein: MIOREX complex component 5 (Mitochondrial organization of gene expression protein 5) (P47007)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Mitochondrial translation factor ATP22
- ATPase expression protein 3
- Nuclear control of ATPase protein 2
Sequence:
MRRTFSQLATRLLKSKDDELKSTLKYLTKGPVKLLGPLFESSEVNEQGSLLNRSRTKENNLQNHHIENILRILNSNLPEVESKKQKVAVHYDVLFSHLNSIVTQATDNKSSSSKELQGSSSEDLYDRLLLLQYVGKLTNVRQITEILLSKKFNKFDKVWEHRALFDEYQRVVISILLYYRTHDVQIRKDYEPRWLSDYSDLPFPLRRLLWRCLTSNVSEDNIRQNIIHYIKLLGANWRNNDLILIYQSLYEKSHILPDLTVLNHNKDDGFSFTQNQILLVRILRAISKCVEEEPKLVKKWLIDIVKLSIQSKIMLESPKKPSTPIMDQYKFIRSLDISIRSIHRTCQDKLIFEDLQVNLGSVLKMINEEEHELKTHLPLNLI
Protein: Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) (P49585)
Organism: Homo sapiens (Human)
Function: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P19836}. Membrane {ECO:0000250|UniProtKB:P19836}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10480912}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Nucleus {ECO:0000269|PubMed:10480912}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000250|UniProtKB:P19836}.
Interaction partners:
- Choline kinase alpha
- Choline/ethanolaminephosphotransferase 1
- Cholinephosphotransferase 1
- Choline/ethanolamine kinase
- Choline-phosphate cytidylyltransferase B
- Phosphoethanolamine/phosphocholine phosphatase
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 9
Sequence:
MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED
Protein: RuvB-like helicase (EC 3.6.4.12) (Q9FJW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Actin-related protein 4
- SWR1 complex subunit 2
- SWR1-complex protein 4
- RuvB-like protein 1
- SWR1 complex subunit 6
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Protein EIN6 ENHANCER
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Actin-related protein 5
Sequence:
MAELKLSESRDLTRVERIGAHSHIRGLGLDSALEPRAVSEGMVGQVKARKAAGVILQMIREGKIAGRAILIAGQPGTGKTAIAMGMAKSLGLETPFAMIAGSEIFSLEMSKTEALTQSFRKAIGVRIKEETEVIEGEVVEVQIDRPASSGVASKSGKMTMKTTDMETVYDMGAKMIEALNKEKVQSGDVIAIDKATGKITKLGRSFSRSRDYDAMGAQTKFVQCPEGELQKRKEVVHCVTLHEIDVINSRTQGFLALFTGDTGEIRSEVREQIDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENEMSPILVVATNRGVTTIRGTNQKSPHGIPIDLLDRLLIITTQPYTDDDIRKILEIRCQEEDVEMNEEAKQLLTLIGRDTSLRYAIHLITAAALSCQKRKGKVVEVEDIQRVYRLFLDVRRSMQYLVEYQSQYMFSEPIKNDEAAAEDEQDAMQI
Protein: Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Pr22 protein) (Prosolin) (pp17) (P13668)
Organism: Rattus norvegicus (Rat)
Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Signal transducer and activator of transcription 3
- Cyclin-dependent kinase inhibitor 1B
- Serine/threonine-protein kinase Kist
- Serine/threonine-protein kinase Kist
Sequence:
MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHVEEVRKNKESKDPADETEAD
Protein: Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) (P20742)
Organism: Homo sapiens (Human)
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular location: Secreted.
Interaction partners:
- Chymotrypsinogen B2
- Chymotrypsinogen B
Sequence:
MRKDRLLHLCLVLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLESGRENRSLFTDLVAEKDLFHCVSFTLPRISASSEVAFLSIQIKGPTQDFRKRNTVLVLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQITNTGFEMKLRVEARIREEGTDLEVTANRISEITNIVSKLKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSISVNKLFVRVFTVHPNLCFHYSWVAEDHQGAQHTANRVFSLSGSYIHLEPVAGTLPCGHTETITAHYTLNRQAMGELSELSFHYLIMAKGVIVRSGTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKVFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGEESYCICGNERQTLSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGIEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVTNPIVRNALFCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLTAQPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTNFQVDNNNLLLLQQISLPELPGEYVITVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLTISYTGNRPASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDYYETDESVVAEYIAPCSTDTEHGNV
Protein: Pumilio-repeat, RNA-binding protein, putative (Q384Z6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGKKGTLQRSQQRQVRHTRENRERKSIVAKAVRRGDFAATTERLVKRTTPQRAAVSEEKKALLIAQFAQACRLPAACDDLCSLLLCETSAGEEQAGVSRKRPRDDGKLDEETLSHILDVFISLDRQAATTDEDEGEEPLTLLEDLVQDECGGRVVCALLNALGAPSCDEKRKLMVLDVVMRLFEENEALHEHYVACKVMSSLVLNGDHEIQRRALHVLCQGAETLDLIQVKLRNRHTAVTIRRLIERFPTETVSWLKDALGLVETSGGGGKKKQGKTNEHKDGKQDVLLYLANDPVASPVMRTFILHCPSRAAVLRGIDVAALLGSKRGCKFLQEILSHDLTELASNEAAEIFNVVLSACEANIVEMCSSGDANFVVQAAISLIPHTGQKEAVTNFKHLLQLLGPQLSSLVDHPISVHVVVCVVVTANSLPNKAIVEEVAAMLVKRSNVGDLLSDARGSLVVRKLLPLCKVKESKVGELLVSAIERDITALMYDSIGNVMVQEYIKVFGAEKIARSLIKADELLRMCQHVYASHVVVCLFDHVGASTHTALCNALRAHVVTLTRHNNGRFVVEKAIPASRDICDVLLRNFVSLACEKGSQHVLCTLMASLDQQGKGRVVELVLSGLAQMATQQSSSIVLQKLLQMDDLLLQKVREKLKQDPRLRNNLAQNFYGKFVVQISEST
Protein: Ubinuclein-1 (AtUBN1) (Ubiquitously expressed nuclear protein 1) (Q8RX78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be required for replication-independent chromatin assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:25086063}. Nucleus, nucleolus {ECO:0000269|PubMed:25086063}. Note=Localized at rDNA loci in the nucleolus. {ECO:0000269|PubMed:25086063}.
Interaction partners:
- RUN/FYVE domain protein
- Probable transcription factor At1g11510
- Forkhead-associated
- Calcineurin-binding protein 1
- At4g31270
- Chromatin modification-related protein EAF1 A
- Homeobox-leucine zipper protein ATHB-23
- La-related protein 1C
- Peptidyl-prolyl cis-trans isomerase FKBP53
- G-box-binding factor 2
Sequence:
MSEVNEMSGGSIGGELLRASPKVLTAGDRKLLKVELRPGDTTYVSWKKLMRDAGKVNGLSASVPDPPPNANPNLEFRIAPGHPVEIETNEQPHSNRFNAVIEKIERLYKGNDSSDGEELDGAPDDDEYDTEDSFIDDAELDEYFEVDNSTVKHDGFYVNRGKLERMEPSTTSNQQPKKRRRKDSAKPCRDAVDVSDKHTKLSITARKKDQSTAPGSWKTQESPLPSGAQDANTSVPLDDVKHSDRANHQSRNDTSHKSRETGSSSALHQKYSNKSLHQQSTSLLGKSPPNVFAEVTVVRQKENNGMHQLANVTGSRQSSQASKKDGSNVKSKTSILEKAIRELEKVVVESRPPAITENQEADTSSQAVKRRLPRDVKLKLAKVARIAQASQGKHSTELINRLMSIVGHLIQLRSLKRNLKIMIDMGDSATREKDTRFKQINNEVLDMIKAKVSLMESQAIKPEGATSDDFQDSVEKPSLKKFVMDAALEDKLCDLYDIFIDGLDEDQGPQTKKLYVNLAELWPNRLMDYRGIKHAIFRAKERRKALYGNLAKEMDQTKMKKSMKQLVPRTDCTAQPNTELVVQRQHSGEKKLIVDPNATSTSVVTSQTMVDRSNQQQPEKLKGISSSCNPTEETRVVKRKNEAVMAEKQVVLALKKPEHPQTRVIPAPQNLNIPRTTPDLNLPS
Protein: Venom nerve growth factor (v-NGF) (vNGF) (P61899)
Organism: Naja kaouthia (Monocled cobra) (Naja siamensis)
Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases. Binds a lipid between the two protein chains in the homodimer. The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:12359255}.
Interaction partners:
Sequence:
EDHPVHNLGEHSVCDSVSAWVTKTTATDIKGNTVTVMENVNLDNKVYKEYFFETKCKNPNPEPSGCRGIDSSHWNSYCTETDTFIKALTMEGNQASWRFIRIETACVCVITKKKGN
Protein: Inner membrane protein YjgN (P39338)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YjgL
- Uncharacterized protein YfdF
- Putative colanic acid biosynthesis glycosyl transferase WcaC
- Colanic acid biosynthesis protein WcaK
- UPF0153 protein YeiW
Sequence:
MAQVINEMDVPSHSFVFHGTGERYFLICVVNVLLTIITLGIYLPWALMKCKRYLYANMEVNGQRFSYGITGGNVFVSCLFFVFFYFAILMTVSADMPLVGCVLTLLLLVLLIFMAAKGLRHQALMTSLNGVRFSFNCSMKGFWWVTFFLPILMAIGMGTVFFISTKMLPANSSSSVIISMVLMAIVGIVSIGIFNGTLYSLVMSFLWSNTSFGIHRFKVKLDTTYCIKYAILAFLALLPFLAVAGYIIFDQILNAYDSSVYANDDIENLQQFMEMQRKMIIAQLIYYFGIAVSTSYLTVSLRNHFMSNLSLNDGRIRFRLTLTYHGMLYRMCALVVISGITGGLAYPLLKIWMIDWQAKNTYLLGDLDDLPLINKEEQPDKGFLASISRGVMPSLPFL
Protein: GDP-mannose 4,6-dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (Q1LVF8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- GDP-L-fucose synthase
- GDP-L-fucose synthase
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- GDP-L-fucose synthase
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-A
- Fucose kinase.
- Fucose-1-phosphate guanylyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.
Sequence:
MAQCTATTTGGGMNGDSKRKRKVAIITGITGQDGSYLAELLLAKGYEVHGILRRSSSFNTGRIEHLYHNPQTHTEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLTDTVRFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVINFREAYNLFAVNGILFNHESPRRGSNFVTRKISRSVAKIHLGQLECFSLGNLDSMRDWGHAKDYVEAMWLMLQQEEPVDFVIATGEVHSVREFVERAFKHVGKTIVWEGKDEKEVGRCQETGVIHVRVDPKYYRPTEVDYLQGDSSKAFKVLGWKPRVTFEELVKEMVDADIKLMQNNPNA
Protein: SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) (P82979)
Organism: Homo sapiens (Human)
Function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Subcellular location: Nucleus. Nucleus speckle.
Interaction partners:
- ATP-dependent RNA helicase DDX39A
- THO complex subunit 4
- Spliceosome RNA helicase DDX39B
- Chromatin target of PRMT1 protein
- Polymerase delta-interacting protein 3
- THO complex subunit 1
- THO complex subunit 7
- UAP56-interacting factor
- THO complex subunit 5
- THO complex subunit 2
Sequence:
MATETVELHKLKLAELKQECLARGLETKGIKQDLIHRLQAYLEEHAEEEANEEDVLGDETEEEETKPIELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLESKKAARAARFGISSVPTKGLSSDNKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA
Protein: Alanine--glyoxylate aminotransferase (AGT) (EC 2.6.1.44) (Serine--pyruvate aminotransferase, mitochondrial) (SPT) (EC 2.6.1.51) (P41689)
Organism: Felis catus (Cat) (Felis silvestris catus)
Function: Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification.
Subcellular location: [Isoform Peroxisomal]: Peroxisome {ECO:0000250|UniProtKB:P21549}.; SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion matrix {ECO:0000305|PubMed:8168541}. Note=More than 90% are mitochondrial. {ECO:0000305|PubMed:8168541}.
Interaction partners:
- Threonine aldolase 1
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Phosphoserine phosphatase
- (S)-2-hydroxy-acid oxidase
- 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- (S)-2-hydroxy-acid oxidase
- Aminomethyltransferase
- Pipecolic acid and sarcosine oxidase
- Peroxisomal targeting signal 1 receptor
Sequence:
MFRALARASATLGPQVAGWARTMATCQLLVAPPEALLRPLSIPNRLLLGPGPSNLAPRVLVAGGKQMIGHMHKEMFQIMDDIKQGIQYVFQTKNPLTLAISGSGHCALEAALFNILEPGDPFLVGVNGIWGQRAADIGERIGARVHPMIKDPGNHYTLQELEEALAQHKPVLLFLTQGESSSGVLQPLDGYGELCHRYNCLLLVDSVASLCGTPIYMDQQGIDVLYSGSQKVLNSPPGTSLISFSDKAKNKIYTRKTKPVSFYLDMKWLANIWGCDGKPRIYHHTTPVVSLYSLRESLALIAEQGLENSWRQHREVTAYLHGRLQGLGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVNYVMDHFDIEITGGLGPSMGKVLRIGLLGCNATRENVDRVIQALQEALQRCSRNKL
Protein: Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (Q54NP6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May be required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in vesicle fusion with nsfA and probably SNARE proteins.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10727946}; Peripheral membrane protein {ECO:0000269|PubMed:10727946}.
Interaction partners:
- Vesicle-fusing ATPase
- Sec1 family domain-containing protein 1 homolog
- Vesicle-trafficking protein SEC22b
- t-SNARE family protein
- V-SNARE family protein
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Synaptobrevin-B
- Synaptobrevin-A
- Syntaxin-7A
- Gamma-soluble NSF attachment protein
Sequence:
MGDDAKAKEFLDAADKRLRGGNFFKMFGGGSSRYDDAASDYTKAANLFKMSKKWDQAGAAFQKAAECFLKGSSKHDAASSYVLAAGCYKKGNVIDAITCLKAAIEYYTDEGRFAISAKHQKEIAELYEAEGDFDQAIASYQIASDYFDGENSTVSSHQCLLKIALFSAQLERYEKSIEIYEQVAAASLDNNLTQWGCKEYFLRACLCYLAADDVVGAERALQRYKDMQASFNSTRECRLLDGIIQACRNNNVEDFTNEVAEFNSISPLDSWKTSILLRIKNTINRETESVV
Protein: N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP) (P25090)
Organism: Homo sapiens (Human)
Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts as a receptor for humanin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11689470, ECO:0000269|PubMed:15465011}; Multi-pass membrane protein. Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011). {ECO:0000269|PubMed:11689470, ECO:0000269|PubMed:15465011}.
Interaction partners:
- Annexin A1
- Cathelicidin antimicrobial peptide
- Amyloid-beta precursor protein
- fMet-Leu-Phe receptor
- Guanine nucleotide-binding protein G
- N-formyl peptide receptor 3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Humanin-like 8
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Protein: 14-3-3-like protein 1 (Partitioning defective protein 5) (P41932)
Organism: Caenorhabditis elegans
Function: Required to modulate lifespan, in concert with hcf-1, acting redundantly with 14-3-3-like protein ftt-2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16777605}. Nucleus {ECO:0000269|PubMed:16777605}.
Interaction partners:
- Forkhead box protein O
- WW domain-containing protein
- Raf homolog serine/threonine-protein kinase
- Partitioning defective protein 3
- Ribonuclease kappa
- Ribonuclease kappa
- NAD-dependent protein deacetylase sir-2.1
- Kinase suppressor of Ras A
- Yes-associated protein homolog 1
- Dual specificity mitogen-activated protein kinase kinase mek-2
Sequence:
MSDTVEELVQRAKLAEQAERYDDMAAAMKKVTEQGQELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSEKKQQLAKEYRVKVEQELNDICQDVLKLLDEFLIVKAGAAESKVFYLKMKGDYYRYLAEVASEDRAAVVEKSQKAYQEALDIAKDKMQPTHPIRLGLALNFSVFYYEILNTPEHACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDVGAEDQEQEGNQEAGN
Protein: RNA-binding protein 42 (RNA-binding motif protein 42) (Q9BTD8)
Organism: Homo sapiens (Human)
Function: Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. {ECO:0000250}.
Interaction partners:
- U4/U6.U5 tri-snRNP-associated protein 1
- U1 small nuclear ribonucleoprotein A
- Heterogeneous nuclear ribonucleoprotein K
- Ubiquitin carboxyl-terminal hydrolase 39
- U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
- U4/U6 small nuclear ribonucleoprotein Prp31
- U4/U6 small nuclear ribonucleoprotein Prp3
- Pre-mRNA-processing factor 6
- U6 snRNA-associated Sm-like protein LSm5
- Probable ATP-dependent RNA helicase DDX23
Sequence:
MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVPGIPTAVPAVPTVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR