wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein Helios (Ikaros family zinc finger protein 2) (P81183)
Organism: Mus musculus (Mouse)
Function: Associates with Ikaros at centromeric heterochromatin.
Subcellular location: Nucleus.
Interaction partners:
- Forkhead box protein P3
Sequence:
METDAIDGYITCDNELSPEGEHANMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETSDSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDRQSYQGNPALNPKRKQSPAYMKEDVKALDATKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH
Protein: Trafficking protein particle complex subunit 11 (Q960U6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222}.
Interaction partners:
Sequence:
MKRRDAAMEAYAAMQASSEATPTPIQNPLSLYTEFFGIRAVKTGDLVAEQQANMQLCDQERSYNHSAAIIALLSQAMAQFKIYKCLRFRKKLAIDMAEEYLKSGDHAKALTLYSLMLPDYRQEKWTTIFTDVLLKTLRCALLSGSVADYIACSVEALSLRHQSDQSERILILENLWQVFQGVPPMPKTQLTPEAQALWTSALANVKSPIQIDLDKVNDVVEMCATFERVQLSNDDLLQLQLIVRVLTDIPLRIRSFHVILADAGNPQNSYKLEALKYFCFPTLTQLRGQKQPDDEQLENPSQEPKNFEKNMRLEPGSYYQLFCSTEAQQFHENTQLRIVRLEAHMGTDQVAALLTCSSNYSRQLFRHHTRSRDLDDNVTINPICYIAPTFHLDTQTNLGHGHDNGLTDDKEMVATKMLVNEYFPVVTTVSNPYNVYLQNVGVHISIPVGLRNSVFLTTDISPGRQKLHSQIQIDVGELSAHGSNTATFYIFSLTEAEIKLAQRLSYTLDVDRGPGGGGSNARVSTAPNSSESTPDHEVKSVIPSVAAISPVQIEYLDETRLRKSREDTLTVRCYGDFKFNARFYTMDRKPLNQVYRGENFLLRANTEVVAVDDVEILDSFFICDHNLVQSNYSFKQKKYTNKYSAGEQLESVIVLRTNATLRDWATARDLDHRGKLEGKAVASKFIRPVPKPSSEEPLAPTPPAGISAYMSKSLVTKIPTTMTIINSNSAVSNALQVANAGVMSNSTQSDDVNVAEEAINTHEGIKTTRLIYNKALEAVQGTGHCRGFIKKIYTLEGNPSAVPIFGVFCIRWRRANCKEENESKFVIRGLDIAEPPLNIYCTIEEKMFVKMPMAFKVVLKNPTTHVLHLIANLSISKTDNFICSGHKQLDISIMAYEEKELVYNLYPLQVGWQELPVLSLEYNTKADPQKKDSQNALLDELVQRALPKRVFVLPPLKQQNK
Protein: Serine protease ea (EC 3.4.21.-) (Protein easter) (P13582)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo.
Subcellular location: Secreted {ECO:0000269|PubMed:9477324}.
Interaction partners:
- Protein spaetzle
- Serine protease snk
- Serine protease inhibitor 27A
- Serine protease gd
Sequence:
MLKPSIICLFLGILAKSSAGQFYFPNEAAQVPNYGRCITPNRERALCIHLEDCKYLYGLLTTTPLRDTDRLYLSRSQCGYTNGKVLICCPDRYRESSSETTPPPKPNVTSNSLLPLPGQCGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDWRLSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRLAQQVEYTDFVRPICLPLDVNLRSATFDGITMDVAGWGKTEQLSASNLKLKAAVEGSRMDECQNVYSSQDILLEDTQMCAGGKEGVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVGKYVDWIQNTIES
Protein: Uncharacterized protein C13G1.09 (O60071)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Ribosome biogenesis protein enp2 homolog
- Ribosome biogenesis protein bms1
- Serine/threonine-protein kinase rio2
- Small ribosomal subunit protein uS3
- KRR1 small subunit processome component homolog
- Ribosome biogenesis protein tsr1
- U3 small nucleolar RNA-associated protein 20
- rRNA processing protein rcl1
- Probable nucleolar complex protein 14
- Protein LTV1
Sequence:
MPKAPKTKLHHAPLYKDIAESSESGVLRQKPSKQKKSKESNTGNGFLDAKTSKKILQLAREQKEELDEEENGKPSQISAFISNGHQKDTLENPAIESSYEESEHARNVSDSESITSQEEEEYEELEIDDADRDLFDRFLPTVSGEEGDLTEEKTTSLSDLIMQKINEAEARARGEYIPSAEEEENALPPLPPKVIEVYSKVGVLLSKYRSGKIPKAFKIIPTLSNWEDILYLTRPDMWTPHACYEATRIFISNLKPVQAQHFLTVIILERVRDDIRENKKLNYHLYMALKKALYKPSSWFKGFLFPLVQENCTLREAAIIGSILQKVSVPVLHSAAALLRLTEFDLSGATSVFIRILLDKKYALPYKVLDSLVFYFMRWKSLERPLAVLEHQSMLVFAQRYKFDITPEQKDALLEVVRLKGHYSIGPEIRRELLNSASRGEEIPVEMEY
Protein: Amino-acid acetyltransferase, mitochondrial (EC 2.3.1.1) (Arginine-requiring protein 6) (Glutamate N-acetyltransferase) (N-acetylglutamate synthase) (AGS) (NAGS) (O94330)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Arginine biosynthesis bifunctional protein ArgJ
- Protein arg11
- Putative alanine aminotransferase
- Probable NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Argininosuccinate synthase
- Probable argininosuccinate lyase
- Argininosuccinate lyase
Sequence:
MQKPSLSQDLIWILKSVQSRRSTKGFLQKHSSLKDGSPNKKSFAQPISSSFLNRISITKIDDVDSLSDNTLYGIGRSINSLARLGIQSVIVPTSNPIGMTSPFKYLENGTVVAKKRKLSIFEELQQQQNRVIRVSEIFSKAGVLTRPSYSSVCQLGPEGPSVENVQGIFQALSSLYTVIVPSSILMPNVIEVPIDGNEVLAGLTYSLHKPNFGFWVDRIVILDKNGGMPCSKRQTGSSHVLINLAQEFDELAKTLPPYHRKNLILVRRCLKMLPDDASALITTPEDAMLTNPVLDKNPLIHNVLTDRSIISCSLPRDRSPITKTTVLRSGVPVYTFLGPKCLTDGSVSWERLWVLINDSFKRTLDMDAYLDRLKNSLAAVIIAGDYLGTAIVTYEQPDGTTNEKVPYLDKLAVSQGAQGSAAISDVMFNVMTDLFPKELIWRSRLTNPVNKWYFERSVGSLKSSKTPWKLFWTGDSHVRNLDRVNQYMSVIDKIQPTWLN
Protein: Ubiquitin carboxyl-terminal hydrolase, putative (EC 3.1.2.15) (Q38F03)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Polyubiquitin, putative
Sequence:
MNQNNLSCEDSDVSTNPGNASPGSGDDSGTSSEGHPSCVDNSVSPSVSSLLSQAEKSATDSVHAEEEHLEKDTELRQGMKQGGFVKSAGRGSKDPLALDQAVAPAIPVPFVGLINEGCTCYLNSLLQMLFHLCYFRNAVYLTPTDANDESCSIPRALQSVFHEMEIRRTPVHTKKLTAAFDWTESELYSQHDIQEMATLLRDNLEERMKGSVSEGAINRMFEGYGEQVVATLDKSFCSRSRDTFYDIHLPLEGHTNLMDSLRSLTARDMLVGDNKYRVEEPGREPQYKDAQKSYEFRRFPPVIWFHLKRFEMDLTSPILETKKVNSYLEFPVELSLEELEHETPSNWGEYATQVFAGDMGDEKKMTGDDGGEKRKRRKGDNEVATAIARPFSRDTPAVYDLQGVIVHKGSVRSGHYYCYIREWDATEKRFTRWLEFDDERVTVVSQEVAVNDNFGVPVPTEGRPLWHMPTNNAYMLSYVRRADCQRMFERPKNNIVPQCVRDQLREEIQEEKRREEEANMRRRKLVLYVLTDEIISEHVKRVQRETFPSDPRIWEEVCFRVEVEKTTPLQMVYVSVAECVPNVKKRFRFDDFRLWLSPWTSHIHVAVPLQLTESTKNCSLTEYLNYRNDDKSPLMHFLVYLQRRTTLPQLYVPNTASLFVNQRLGAEAVAACNGCTIILPKPTPISSITFYTIYFSDYAAPCNVHICLYAADDQKTPCESKTCTLSRDLCMFDVNSTGQKIALIRCAVRGSLAWVYLLANERPSMSSLRVTYGCEGEGIEETNISSLPRIDRCAVLVFLKYFNPVTRHVAYAGSAMIPLHATVADCGRVLLRLLGEDPDLVDTLLIYEESQCQNVLLDNEKTLQNSGIIVGSVLIAQQRNSRVHSYTDVNDYLLSLPNFIHVKATHSVFEERYMFSEEDSGYEADNVEGSDDCVVPARPAVVEASIPMSDADSEVRGQTTFYPPRNFHVIKAYMLTLDSQLKYDEVCEAIGTASGHDPAFIRLYKGTCGGNPNCGEILTPEVDPAPSDMVLSGLLWGNRVDVIFFEVLREPRRVVECRPRLVVTVRGRKNEAIYKEKLVVPQGTTVGDVVEQAVRRCAITVERTFCSDGGAGVALDAGGSVNRCSRSRSNNSEVISSQVITPFVISPHYLALVVDPRERLINCIIEVPVMEDGTCDCNCFIDDLVSQAVAAYGTAGLCAPVEPLTIFVVPAPPLQKDQFRIACCHGEVFADRDDSLPLMFGQPFVVTADYHATVETLRDILLEYTGVPANEVVPLQRGVVVIATRRSVFLPWSECFFEFVRREERKRGPFTPSLLLNHRRPREKPGSRYVAQAAPALRISRR
Protein: LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1) (Q9R1R0)
Organism: Mus musculus (Mouse)
Function: Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein Nkx-2.1
- Homeobox protein DLX-1
- LIM domain-binding protein 1
- Homeobox protein DLX-2
- Calretinin
- T-box brain protein 1
- Somatostatin
- Parvalbumin alpha
- Homeobox protein MSX-1
- Pro-neuropeptide Y
Sequence:
MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIYCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPTRLPSALSDDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADLDGPLSSRGEKVILFQY
Protein: NK1 transcription factor-related protein 1 (Homeobox protein SAX-2) (NKX-1.1) (G3UXB3)
Organism: Mus musculus (Mouse)
Function: May be required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis, possibly by regulating the transcription of specific factors involved in energy balance.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MSTSGPAAPGDVPALPPPPPGPGSGPAPPAPAATARDTMDGRAELPIFPRAGVPPLAASDTVPAVPEGAGAARPAAPPRPTSFSVLDILDPNKFNSRRRRCVLLGPVVPATCAPCAPAACVAVPAASGRSPRAELERRALSAATGVAAAAGAEPTSAGDSYRADEAEANGYSSGSGRSPTADSEDEAPEDEDEEEAPEVQDAQGTEEPRGGSGGLGARGSGCPGAAEVEASPVDDTAAPGPRGNSPGAPGPPATATGAGSAGSTPQGAAVTTKPKRKRTGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTGGGGGPGPGAGPGAGLPGGLSPLSPSPPMGAPLALHGPAGYPAHSPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPAFYAPHL
Protein: Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) (P67828)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P48729}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P48729}. Nucleus speckle {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton. {ECO:0000250|UniProtKB:P48729}.
Interaction partners:
- Glycogen synthase kinase-3 beta
- RGS domain-containing protein
- Catenin beta 1
- Axin 2
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
Protein: Candida glabrata strain CBS138 chromosome A complete sequence (Q6FXS8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Topoisomerase 1-associated factor 1
Sequence:
MSTAASNDHPDGGGKQSTTKKATKRASKSEESGQKKKVKKESTSKISSPDDNHSVTSTSTVLSQHMNGSMSSNGANLGTTHRPVTSCTHCRQHKIKCDASQNFPAPCTRCAKNGFHCEINPQFRPKKGSMMQMLAHEVDELKYKVSYLIRNDGLIAKALANHKEGQDILRVLNTNPPGYYQEGKSEINTNSPSVNHALTPNHETNSNSSPNTKISVQTYLAGDHPLVSQDTKSPTASGNAVPTQAMNMNRNDIIGTKYTTSVNKPILPPILNDSTPTNNSSKAQINSGLLQMAFHRNSSTTGSPSTSRPLSPLVPNGATSHGMINNDIGLQQAGQVGAKKSPIIATTTTMDPLPSPQANIDEFVLGDIRLSINKADELHSTFLTKYLPYFPIMSSNSATELFGQSQLLFWTVMLTASMSEPEPTLYMKLSTLIKQLAIETCWIRTPRSTHISQALLILCNWPLPNQKVLDDCSYRFVGLAKSLSYQLGLHRGEFIYEFTRTQTSMPDAEKWRTRTWLGIFFSENCWSSILGLPPNSKPDYLTEKAKKAEIYEDNVDKTSEITSKESNKGKAKETNGHANEISDNKMTLPKRFKQMLILADFQGKLCNIMGTSVTSPDGLMEPSYRSDALSVLDKELEELNTTYKFDTDDVVNIYYLYIRLMIYCFAFLPGTPAQDQLVYVNPAYTAATKIVTLLTQLLKDQQLIELPIYIRQSASYASLILFKLQLSPALSDKCFESARQSIVTIHRCYRNQLSAWATVVENDISRTASMLEKLNFVLITHPEVLVEEAGIISRMRSHMTGSLFYDLVWCVHEARRREVDPEYNRQVLEDVKKSHEKDGSKQSYHIPASKLYPLPLYNQISKEDFKTVTKTTPNGTTVTTLVPTRSALRQAESNSNNDGGAVAINGIPLAMLDENGSLDMDNLFSLQNIAPVNGDGAIYPRMIDSIIRPEDIPDRPNSAMATIAPSDRQDFGNKGDVNSSTQQGVNPPNDFMMERQASFPPTQNPRTTGSSLASLPEIPKNGKSFKDFANIAQWGNFASNPTSGPNKNNKNDIPSANSRLQLNQLSDFFQQQSAGWIEGNLGNDDFFGWLDMNMEPKF
Protein: Docking protein 7 (A0A2R8Y701)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVAGAGVFFLSSAEGEQISFLFDCIVRGISPTKGPFGLRPVLPDPSPPGPSTVEERVAQEALETLQLEKRLSLLSHAGRPGSGGDDRSLSSSSSEASHLDVSASSRLTAWPEQSSSSASTSQEGPRPAAAQAAGEAMVGASRPPPKPLRPRQLQEVGRQSSSDSGIATGSHSSYSSSLSSYAGSSLDVWRATDELGSLLSLPAAGAPEPSLCTCLPGTVEYQVPTSLRAHYDTPRSLCLAPRDHSPPSQGSPGNSAARDSGGQTSAGCPSGWLGTRRRGLVMEAPQGSEATLPGPAPGEPWEAGGPHAGPPPAFFSACPVCGGLKGAAASAPGPATAHSGSPGPVAVDSPGPERPRGESPTYVNIPVSPSSRKQLHYMGLELQEASEGVRGAGASLYAQIDIMATETAHRVGVRHARAREEQLSELEQRKAAPQ
Protein: RNA exonuclease 3 (EC 3.1.-.-) (Q12090)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Oligoribonuclease, mitochondrial
- RNA exonuclease 1
- Exosome complex exonuclease RRP6
- PAN2-PAN3 deadenylation complex subunit PAN3
- RNA exonuclease NGL2
- Proliferating cell nuclear antigen
Sequence:
MGSLLRPVDLVNQPLGFQERYKILQKLFKQLQKAYAHTKGTNIDLERLATRLEVHVAKNSLSGQSYKFNMSILLRDVLKYKGDLSKIKINGRPLKGAKPHLSSIGNANSITTKSKAMEALKALILDSKVLEKNGYIVKEMQNKTNDDNSTQLYAPCLRCSSNFKKTDIMEKTLCRYHPLKRIYNRDTKNHQYPCCGETTDSVSFLRLGCKTFFHHVFRGESYDELCKISKFSSTDDIDGVENVLSLDCEMAFTSLGYEMIRLTIVDFFTGKTLFDHVIQPIGDIVDLNSDFSGVHEIDRTNCPTYKEALDVFLSENLINKNSILIGHGLENDLNVMRLFHNKVIDTAILYSRTKFKVSLKNLAFEVLSRKIQNGEHDSSQDAIATMDVVKVKIGISPSQNKWEK
Protein: Endothelial PAS domain-containing protein 1 (EPAS-1) (HIF-1-alpha-like factor) (HLF) (mHLF) (HIF-related factor) (HRF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (P97481)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:21546903}. Nucleus speckle {ECO:0000269|PubMed:21546903}. Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles. {ECO:0000269|PubMed:21546903}.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator
- Histone lysine acetyltransferase CREBBP
- Hypoxia-inducible factor 1-alpha
- Egl nine homolog 1
- von Hippel-Lindau disease tumor suppressor
- Aryl hydrocarbon receptor nuclear translocator 2
- Prolyl hydroxylase EGLN3
- Prolyl hydroxylase EGLN2
- Hypoxia-inducible factor 3-alpha
- RNA-binding protein 4
Sequence:
MTADKEKKRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKNGSGFGKKSKDVSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCPPHSSLCGSKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSDDVAVTEKSNYLFTKLKEEPEELAQLAPTPGDAIISLDFGSQNFDEPSAYGKAILPPGQPWVSGLRSHSAQSESGSLPAFTVPQADTPGNTTPSASSSSSCSTPSSPEDYYSSLENPLKIEVIEKLFAMDTEPRDPGSTQTDFSELDLETLAPYIPMDGEDFQLSPICPEEPLMPESPQPTPQHCFSTMTSIFQPLTPGATHGPFFLDKYPQQLESRKTESEHWPMSSIFFDAGSKGSLSPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWPVGDQSAESLGALPVGSSQLEPPSAPPHVSMFKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLEYEEQAFQDTSGGDPPGTSSSHLMWKRMKSLMGGTCPLMPDKTISANMAPDEFTQKSMRGLGQPLRHLPPPQPPSTRSSGENAKTGFPPQCYASQFQDYGPPGAQKVSGVASRLLGPSFEPYLLPELTRYDCEVNVPVPGSSTLLQGRDLLRALDQAT
Protein: Eukaryotic translation initiation factor 5 (eIF-5) (Q07205)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Eukaryotic translation initiation factor 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2, subunit 2
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit I
Sequence:
MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEKKNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKDIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI
Protein: GH04191p (Q8T0U9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEERHSRGRSHSHYPYEGETEDSVRGAAHHETKSLRETHHKRNHDSARSRRHQDPKVERERERDRERDRTWRRRSNKYHSGGEDPDRSYDHSRRYNNSNYEGESDNPEYNHMGDAELDGSGGRSSKTSRHRRSAAEEDFDDYERERNRSRRSTKPQSSAEKSRSSGGRRNYENSGRSARADDGRRRYQDQRNPGAQYPVSATGYVPYGMYEQMSRNPQVYADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERAAADAAPSTYGGVAGTAGPVTNTAVARPPRRRTPLQFSRPHLVASYAMSLLTLDTWNGNYQTTNNHPTTQTL
Protein: Si:ch211-149p10.2 (A4JYN9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRRFSELIVCLVTLVVAEDQRPEIRAIAGEDAVLSCSAKSETGVQYRSVIWYKVDEAEPSQQLTGLVRKRLTKDDGKVEKYNGVEREVVLLEDSKNLILSNVTAEDSGIYRCFLSAPLGYQNQRGDIILTVYKPQTVERMEFNKSSLVYLGEIAAIAGLFLGFLFFGISYVYIRSFNQRGKKLSLLKMPSPGKNLITSNHLICKTLPEVYV
Protein: SET domain-containing protein (Q38AF4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone H3 variant
- Histone H3, putative
- NAD-dependent protein deacylase SIR2rp3
Sequence:
MICKVLERIVRQILQRACIAMTARRLADILHGVVSVDNMTAVCLKMTESGVLERWGDDAFVLKDSSNAAVRNILVTPEYQDLGMTVLRVGERKVVKYIPREAEHRFFEVRQSILGRRAGLGLFLRSSRALRQGTVMCEYTGRLLRRPPKEHEQSIYVVRLRTAAYFVDGVDENGEHLSLATFINDNGPEAANAAMQEYDMLAGRVFVVAARDIDPGEEVFCTYGSTYWGCSSYDELHHKINGGQRKRPRDDDPDEFSCDFFYRCRRCGEEVTKRLMSLHARTCGDKLVKKKLISLNCLPFNEFTAMENSSKVLPASRQRMLRRAKHFVDLEEPQTFGLSHEDVVGDVTFTWSAS
Protein: Early transcribed membrane protein 4 (Q8IFM9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Merozoite surface protein 11
Sequence:
MKLSNLFYVFALLISMNVFVPGFMNVLGKNVNVDSIVMSKIDEMQKKKQQQKIIMISTVVTGLALLLGSALGFGYLSKSNKKPEVSGDEKDESKKVDAGKNNKESKADKSEEKLHKSDDRESKSSSSKSTAVPTTV
Protein: Mitochondrial transcription factor 1 (EC 2.1.1.-) (Q9US51)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA-directed RNA polymerase, mitochondrial
- Probable citrate synthase, mitochondrial
- Uncharacterized 91 kDa protein in cob intron
- Probable isocitrate dehydrogenase, mitochondrial
- Cytochrome c oxidase subunit 3
- Uncharacterized cox1 intron-2 37.2 kDa protein
- Serine/threonine-protein kinase srk1
- Zinc finger protein C25B8.19c
- Non-histone chromosomal protein 6
Sequence:
MKLPKILYDAAAFGGPRSTGFVKILNLNGRSSYKSSYLVNQNLMDEALVKSNLLKEYNSEKMTILEMAPGPGVTTTSLFNYFQPKSHVVLESREVFSKPLQKLCTLSDGRIKWVHQDGYYWQTYEDVYVSKVLDPRIQTEEEQKLSPHRELLFFAHLPHGYAGLLFVSQILDFLSARDWLGIFGRVRVLLWLPCSPTVTLLGSRGFSKRSKTSVFREAFTDSRVLAASESTLQKLCMGYSKEAKENYQISPNPLLVSPTPITSEPHKEDLTLVEMCSKPQDKQLSIPVFESIVRILLTCKATSLSKSIYYLGPGAETLLPSFTQCGINIDMPVGLLSAADFLTISKIIQKYPFKHHLHLGTIIEDS
Protein: Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain protein) (Q9I9N5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q3U0V2}. Cytoplasm {ECO:0000250|UniProtKB:Q15628}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q15628}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q3U0V2}.
Interaction partners:
- FAS-associated death domain protein
- Tumor necrosis factor receptor superfamily, member 1a.
- Tnf receptor-associated factor 5.
- Receptor
- TNF receptor-associated factor
- TNF receptor-associated factor
- Receptor-interacting serine-threonine kinase 3.
- Caspase 8, apoptosis-related cysteine peptidase
- Caspase 22, apoptosis-related cysteine peptidase
- RING-type E3 ubiquitin transferase
Sequence:
MDSIDTKRLNDSNASDRALSGCAVLFLGCSSLEHNFLSLYKDERGKFSVFKVIKLTLSDSVGGLEGYEILKLHDADPYLGVELKFMAMPPCQRFLESYACGSLTQFLSQHASRLLALPDGVEIETQLKAGVHTLDHSLQDIEICLDHIRQSQPVRLRDDEVTQLEQQLQNSYGPPSQPPQELPRNCFLFQKRVFDDRPLTPADQQRFAAHVGRDWKRVGRALQKNCRALKGPAIDNLAYEYEREGLYEQAYQLLGRFIQSEGRSAKLSRLISALEETKMTSMAEIMLGIQPRD
Protein: Vacuolar cation-transporting ATPase YPK9 (EC 7.2.2.-) (PARK9 homolog) (Q12697)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Vacuolar transporter which plays a role in sequestration of divalent heavy metal ions.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:19345671}; Multi-pass membrane protein {ECO:0000269|PubMed:19345671}.
Interaction partners:
- Proteasome subunit beta type-4
Sequence:
MDIPSSNQIQHGQRSERNRRMPRASFSSTATTSTAATLTSAMVLDQNNSEPYAGATFEAVPSSIVSFHHPHSFQSSNLPSPHSSGNLEQRGRRLTESEPLVLSSAEQSRSSSRNPSHFRFFTQEQISNAEGASTLENTDYDMAWDATPAYEQDRIYGTGLSSRRSSIRSFSRASSLSNAKSYGSFSKRGRSGSRAPQRLGENSDTGFVYHSATHSSSSLSRYTTRERIPIELESQTDEILEDESSTHSLESSDSRRSASENNRGSFSGHDDVHNQHSEYLKPDYHEKFYPQYAPNLHYQRFYIAEEDLVIGIAAYQTSKFWYIIYNLCCFLTFGLVYLLTRWLPHLKVKLYGVKVPLAKAEWVVIENEFGEFVIQPIDRQWYNRPLSTVLPFENYPNPSYEPNDINLSHHHANEINPNVPILITFEYRYIKFIYSPLDDLFKTNNNWIDPDWVDLSTVSNGLTKGVQEDRELAFGKNQINLRMKTTSEILFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISVLSIFDSLNEQKKVSRNLAEMSHFHCDVRVLRDKFWTTISSSELVPGDIYEVSDPNITILPCDSILLSSDCIVNESMLTGESVPVSKFPATEETMYQLCDDFQSTQISSFVSKSFLYNGTNIIRARIAPGQTAALAMVVRTGFSTTKGSLVRSMVFPKPTGFKFYRDSFKYIGFMSLIAIFGFCVSCVQFIKLGLDKKTMILRALDIITIVVPPALPATLTIGTNFALSRLKEKGIFCISPTRLNISGKIDVMCFDKTGTLTEDGLDVLGVQISEPNGVRGQKFGELLSDIRQVFPKFSLNDCSSPLDFKSRNFFMSLLTCHSLRSVDGNLLGDPLDFKMFQFTGWSFEEDFQKRAFHSLYEGRHEDDVFPENSEIIPAVVHPDSNNRENTFTDNDPHNFLGVVRSFEFLSELRRMSVIVKTNNDDVYWSFTKGAPEVISEICNKSTLPADFEEVLRCYTHNGYRVIACAGKTLPKRTWLYSQKVSREEVESNLEFLGFIIFQNKLKKETSETLKSLQDANIRTIMCTGDNILTAISVGREAGLIQCSRVYVPSINDTPLHGEPVIVWRDVNEPDKILDTKTLKPVKLGNNSVESLRECNYTLAVSGDVFRLLFRDENEIPEEYLNEILLNSSIYARMSPDEKHELMIQLQKLDYTVGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSKIFNISCVLDVIREGRAALVTSFACFQYMSLYSAIQFITITILYSRGSNLGDFQFLYIDLLLIVPIAICMSWSKSYEKIDKKRPSANLVSPKILVPLLISVFLVFLFQFIPWIIVQKMSWYIKPIVGGDDAVQSSDNTVLFFVSNFQYILTAIVLSVGPPYREPMSKNFEFIVDITVSIGASLLLMTLDTESYLGKMLQLTPISNSFTMFIIVWVILNYYAQLYIPPSIKGWLKKKKSSKKYKLLIQEEMKLKEV
Protein: CAP, isoform E (CAP, isoform N) (DCAPS) (Q966U7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVERA