wanglab/gogpt-training-data huggingface dataset:
Protein: cAMP-dependent protein kinase type I-beta regulatory subunit (P12849)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Subcellular location: Cell membrane {ECO:0000250}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit PRKX
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- cAMP-dependent protein kinase type II-beta regulatory subunit
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Hormone-sensitive lipase
- A-kinase anchor protein 1, mitochondrial
- Serine/threonine-protein kinase Sgk2
- A-kinase anchor protein 10, mitochondrial
Sequence:
MASPSCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIGGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV
Protein: Multiple organellar RNA editing factor 9, chloroplastic (RNA editing-interacting protein 9) (Q9LPZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in organellar RNA editing. Required for the processing of multiple editing sites in plastids.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:25583991, ECO:0000269|PubMed:28213559}.
Interaction partners:
- Protoporphyrinogen oxidase 1, chloroplastic
- Organelle RRM domain-containing protein 6
- Pentatricopeptide repeat-containing protein DWY1, chloroplastic
- Zinc finger protein VAR3, chloroplastic
- Pentatricopeptide repeat-containing protein At5g13270
- NAD
- Pentatricopeptide repeat-containing protein At5g48910
- Pentatricopeptide repeat-containing protein At3g63370, chloroplastic
- Pentatricopeptide repeat-containing protein At1g08070, chloroplastic
- Putative pentatricopeptide repeat-containing protein At3g11460, mitochondrial
Sequence:
MASFTTTSSSSLLLKTLLPVSHLNRFSTLSGIRVGDSWTPLLRNISTAGSRRRVAIVKAATVDSDYSSKRSNSNEQRETIMLPGCDYNHWLIVMEFPKDPAPSRDQMIDTYLNTLATVLGSMEEAKKNMYAFSTTTYTGFQCTIDEETSEKFKGLPGVLWVLPDSYIDVKNKDYGGDKYINGEIIPCTYPTYQPKQRNNTKYQSKRYERKRDGPPPPEQRKPRQEPAASDSS
Protein: Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193) (A0A0H2URA2)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR015601}.
Interaction partners:
Sequence:
MQQYFVKGSAISPVTIEDKETSKHMFQVMRLKEEDEVTLVFDDGIKRLARVLDMENRQFELVQELNDNVELPVQVTIASGFPKGDKLEFIAQKVTELGASQIWAFPADWSVAKWDGKKLGKKVEKLEKIALGAAEQSKRNIVPSIKLFEKKADFLAQLDQFDSIIVAYEESAKEGEAAALLQAVTGLETGAKLLFIFGPEGGLSPAEIESFEAKGAVLAGLGPRILRAETAPLYALSALSVLVELEK
Protein: Spliceosome-associated protein CWC27 homolog (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (Q9VTN7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA-splicing factor CWC22 homolog
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- CG4973 protein
- Cell division cycle 5, isoform A
- Pre-mRNA-processing factor 17
- Pre-mRNA-processing factor 19
- RNA helicase
- BUD13 homolog
- Eukaryotic initiation factor 4A-III
- FI23980p1
Sequence:
MSNIYIQEPPTSGKVLLKTTVGDIDIELWARECPKACRNFVQLCLEGYYKNTEFHRLVKGFIVQGGDPNGDGTGGESIYGQPFKDEFHSRLRYTRRGLVGMANSGKDDNGSQFFFTFAPTPELQNKNTLFGKITGDTIYNMLKLEDGIVDHQERPMHAHRIVSTEVLSNPFDDIVPRILSQPSTKSKKTKKERQGVKNFGLLSFGEEAEGDEEETNVYVKQNAGKAKSLHDVTDDPKLSKEPIRVPKVEKADIEEHLSDDCPEDSVKDKPSTASSDLIKMKLSKRSKSGADKKVQPVEEKSDSEDDEDVLLTREEEQSRKVSEEKSKIREEIASLKKQYQMDKQSKDKLVNGQEKAAKSNEIKGSSENHYINDFIESKEKYTAKVKLQPKGQSREAFTLSLLSKFRTKLDNLKQKSSSDDGESEPKDIDDRVVEQEIIGDDWLSHTLNFNSTTPVLAKDANKKGDDWYDAYDPRNPLNKRKRGETGSSKSSSGKSKSSKRDF
Protein: Outer envelope pore protein 16-2, chloroplastic (Chloroplastic outer envelope pore protein of 16 kDa 2) (AtOEP16-2) (OEP16-2) (Outer plastid envelope protein 16-S) (AtOEP16-S) (Seeds outer plastid envelope protein 16) (Q0WMZ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars (By similarity). Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:17098851, ECO:0000269|PubMed:17202255}; Multi-pass membrane protein {ECO:0000269|PubMed:17098851, ECO:0000269|PubMed:17202255}.
Interaction partners:
- Outer envelope pore protein 16-4, chloroplastic
- Putative F-box/kelch-repeat protein At2g29800
- Outer envelope pore protein 37, chloroplastic
- NADH dehydrogenase 1 beta subcomplex subunit 3-A
- Late embryogenesis abundant protein 6
- Transducin family protein / WD-40 repeat family protein
- Mitochondrial import inner membrane translocase subunit TIM22-3
- Chloroplastic import inner membrane translocase subunit TIM22-2
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
- Mitochondrial import inner membrane translocase subunit TIM22-1
Sequence:
MEKSGGRIVMDEIRSFEKAHLFDLGHPLLNRIADSFVKAAGVGALQAVSREAYFTVVDGAGFDSNNVGPPSEITGNKKHRFPNLRGESSKSLDALVKNTGKESLQWGLAAGLYSGITYGMTEVRGGAHDWRNSAVAGALTGAAMAMTTSERTSHEQVVQSALTGAAISTAANLLSSVF
Protein: 2-oxoglutarate-dependent dioxygenase DAO (EC 1.14.11.-) (Protein DIOXYGENASE FOR AUXIN OXIDATION) (Q7XKU5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: 2-oxoglutarate-dependent dioxygenase essential for auxin catabolism and maintenance of auxin homeostasis in reproductive organs. Catalyzes the irreversible oxidation of indole-3-acetic acid (IAA) to the biologically inactive 2-oxoindole-3-acetic acid (OxIAA).
Interaction partners:
- Os12g0178000 protein
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase ALDH2b
- Mitochondrial aldehyde dehydrogenase ALDH2a
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase
- Bifunctional nitrilase/nitrile hydratase NIT4
- Os02g0635000 protein
Sequence:
MVEIPAIDLRLAGGGGGAEETARLRDACARLGCFRVSGHGVPPGLQAEMKAAVRALFDLPDDAKRRNADIIPGSGYVPPGTANPLYEAFGLCDAAAPADVDAFCARLDAPPHVRETVKAYAERMHSLIVDVAGKVAASLGLHGASFQDWPCQFRMNRYNYTQDSVGSPGVQVHTDSGFLTVLQEDECVGGLEVLDPAAGEFVPVDPLPGSFVVNVGDVGQAWSNGRLHNVKHRVQCVAAVPRVSIAMFLLAPKDDTVSAPGELVDGEHPRRYREFKYDDYRRLRLSTGERAGEALARLAA
Protein: Translocase of outer mitochondrial membrane (Q76P15)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim17
- Uncharacterized protein
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit tim50
- 60 kDa heat shock protein, mitochondrial
- Bacterial surface antigen
- Mitochondrial import inner membrane translocase subunit tim16
- Probable mitochondrial Rho GTPase gemA
- SMP-LTD domain-containing protein
- Mitochondrial-processing peptidase subunit alpha-1
Sequence:
MEATADNNNNIDSQEQEIIGEPNFFQSFLVKNLPFYKSLPYPGKAEDMISEVKGLVNDDIYEGAKVDVTFKISPFFETSHQLNVYTPNENSRTPKYSNQNVYSKDSTLLYGKIDSERRLFGRFDQGFFNNSIRVSLTNMMDKSFKNNLAGELEFKLPFMNFCLKADTENQRGFSFLTSISKKLAIGYENSYLFNHSQSIKQIQFFVNNPLSTWSLVVGNTAQIGSSYVYRQKNLHIGTDLVMGISQEGKFMSEYSFGVRYAFQQSLVKFRADSHGSIFGSYDQMINSFTKLNLSGSLNYFAQDYKFGLGLTFQK
Protein: Squalene monooxygenase (EC 1.14.14.17) (Q386I4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- NAD
- C-8 sterol isomerase, putative
- Lanosterol synthase
- squalene synthase
- Lanosterol 14-alpha-demethylase
- Delta
- Hydroxymethylglutaryl-CoA synthase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- Cytochrome P450, putative
- C-5 sterol desaturase, putative
Sequence:
MEAAIIGSVVFLAVTVTFLFVLFDHAVSGVRLKEARLNYDYDVIIVGGSIAGPVMAKALADQNRRVLLLERSLFTKPNRIVGELLQPGGMDVLRKLGMDECAKSVGMPCHGYVVLDERGDEIRLPYAAGLQGFSFHFGDLVNNLRKYVWQNCQPAVTMLEATVTEVLVERVAPCVNRAYGVVYTTAAEYNVPESPFTGAPPSRTDSTSMSEEVQKTATAPLIIMCDGGSSKFKAMYQHYDPAANYHSHFVGLIIRNARLPQEGYGTVFFGKKGPILSYRLDPNELRVLVDYNKPALPSLVEQSRWLSEEIAPCLPSNMREDFIKAAQSTQNIRSMPIAFYPATFPSIRGYVGIGDHANQRHPLTGGGMTCAFSDAFLLAEKLLEIKEMRSSDVVEMADIEDSIQNAIVSYARGRVVHSSSINILSWALYAVFGTRLLRNACLEYFARGGECVSAPMALLAGVDHSPQRLLWHYTRVMFNGALNLATLSGPRNCRGKDTPSFGRRCINAATFFVSPFRVLEALYLLIAAACVAVPVAYSEFVSIWRLINPTGFLSSIYKTVRVAVCRSLLNGRKRKPIGL
Protein: Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein (Protein kinase, putative; 86372-89112) (Q9C890)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alpha-1,3/1,6-mannosyltransferase ALG2
- Cysteine-rich repeat secretory protein 59
- Cysteine-rich repeat secretory protein 29
- Sphingoid long-chain bases kinase 1
- Sphingosine kinase 2
- Probable protein phosphatase 2C 61
- Sphingosine kinase 1
- Alpha/beta-Hydrolases superfamily protein
- Pectin lyase-like superfamily protein
- At1g04210
Sequence:
MSREKQGKRSGSNGTEKVLVAVKASREISKTAFVWALTHIVHPGDCITLIVVVTSYNAGRKLWTFPRFAGDCATGHWKLHSDPMSEIKSDLTDTCSQMILQLHDVYDPNKVNVRIKIVSGSPCGAVAAEAKKSQANWVVLDKHLKHEEKRCIDELQCNIVAMKRSEAKVLRLNLVGSSTKEPELASEKNKNRLLDSVKAVVTTTPMSSPEVETSFTGTEAWTSSVSSSDLGTSSPVFTAEVRKDETLVVKENESDSDSESENLSLPSLSKRFQPWISEYLSTHCVSMQESTRGDDKAVQVSTKKALLEKISKLDEGEEAAMSSKRKDLEEYSGTLRALSRNAPPVSPPLCSICQHKAPVFGKPPRFFSYKELELATNGFSRANFLAEGGFGSVHRGVLPEGQIVAVKQHKVASTQGDVEFCSEVEVLSCAQHRNVVMLIGFCIEDTRRLLVYEYICNGSLDSHLYGRHKDTLGWPARQKIAVGAARGLRYLHEECRVGCIVHRDMRPNNILITHDYEPLVGDFGLARWQPDGELGVDTRVIGTFGYLAPEYAQSGQITEKADVYSFGVVLIELITGRKAMDIYRPKGQQCLTEWARSLLEEYAVEELVDPRLEKRYSETQVICMIHTASLCIRRDPHLRPRMSQVLRLLEGDMLMNEISGRFNGRLSTEKGLRDHN
Protein: Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) (P9WHV1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00412}.
Interaction partners:
- Glutamate 5-kinase
- Pyrroline-5-carboxylate reductase
- Glutamate synthase large chain
- Glutamine synthetase
- Probable glutamine synthetase GlnA4
- L-glutamate gamma-semialdehyde dehydrogenase
- Probable glutamine synthetase GlnA3
- Phosphoribosylformylglycinamidine synthase subunit PurQ
- Glutamine synthetase
- ATP synthase subunit alpha
Sequence:
MTVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSLNPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLELPADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTIETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAETALPRLLAALQHAGVTVHLDPDEADLRREYLSLDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
Protein: Opacity protein opA66 (Q05033)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
Interaction partners:
Sequence:
AGEGNGRGPYVQADLAYAYEHITHDYPKPTDPSKGKLSTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWNDSKYSVSIKNLQRRTSNGNRRDRKTENQENGSFHAVSSLGLSAVYDFKLNDKFKPYIGARVAYGHVRHSIDSTKKTTEFLTTAGARGTDPTVSSPYKNTQDAHQESNSIRRVGLGVIAGVGFDITPNLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
Protein: Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) (P83782)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07257}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07257}; Matrix side {ECO:0000250|UniProtKB:P07257}. Note=Localized in detergent-resistant membrane fractions. {ECO:0000269|PubMed:16534748}.
Interaction partners:
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome b-c1 complex reductase subunit, mitochondrial
- Cytochrome b-c1 complex catalytic subunit, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b
- Cytochrome c oxidase subunit
Sequence:
MLSRASIRAYSSIPNSVKIAAKESATDLTKLSVIINNAGSKTGKSGVSHLLSKFTFLNNGAKSALRFTRESELLGGTFESKVTRDALILNTTFLKQDLPYYVEALGNVVSNTQFAPHEFNEIVLPTANAETKLANANPAFKGVEKLHEITFRRGLGNPLFYNESTPIKLEEVAQFSKEQFSGENISIVAEGANEEDLTKFVSESAFCYLPSSSSNGAKALPTNTFTGQEARVPSSGASSALIGIPVKPADFGKYEVLSAAIGTSTLPSTSTPLAQIPGATSHLYKYQDAGLFVISVSGEASQVAQGIKQAKSVAESVSSSALSEAVKAAELSVALQSTVDSPLNVKVVAEEAPISKFNYVAVGDLDVLPYADEL
Protein: Histone H2A (Q0Z946)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
Interaction partners:
- Helicase SRCAP isoform X2
- RuvB-like 1
- Peptidyl-prolyl cis-trans isomerase
- AT-rich interactive domain-containing protein 4B
- AT-rich interactive domain-containing protein 4A
- YEATS domain-containing protein 4
- Actin-related protein 6
- DNA methyltransferase 1-associated protein 1.
- RuvB-like 2
- SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 1b.
Sequence:
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
Protein: Growth hormone (Q91160)
Organism: Oncorhynchus keta (Chum salmon) (Salmo keta)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MGQVFLLMPVLLVSCFLSQGAAMENQRLFNIVVNRVQHLHLLAQKMFNDFEGTLLSDERRQLNKIFLLDFCNSDSIVSPIDKQETQKSSVLKLLHISFRLIESWEYPSQTLTISNSLMVRNSNQISEKLSDLKVGINLLIEGSQEGVLSLDDNDSQHLPPYGNYYQNLGGDGNVRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL
Protein: Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) (Q9BZF3)
Organism: Homo sapiens (Human)
Function: Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:26941018, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:14593528}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:26941018}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8BXR9}.
Interaction partners:
- Vesicle-associated membrane protein-associated protein B/C
- Vesicle-associated membrane protein-associated protein A
Sequence:
MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW
Protein: BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) (D6REL5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF
Protein: Protein BRICK1 (Q8RW98)
Organism: Zea mays (Maize)
Function: Promotes multiple, actin-dependent cell polarization events in the developing leaf epidermis. Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Protein PIR
- Brick3
- Uncharacterized protein
- Protein NAP1
- Dirigent protein
- Protein ABIL1
- Protein ABIL1
- Protein ABIL3
- Chaperonin
- Actin-related protein 2/3 complex subunit 4
Sequence:
MGRGGGMGNPVNVGIAVQADWENREFISNISLNVRRLFDFLLRFEATTKSKLASLNEKLDILERKLEVLEVQVGSATTNPSVFN
Protein: Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) (Q8BTW9)
Organism: Mus musculus (Mouse)
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O96013}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. {ECO:0000250|UniProtKB:O96013}.
Interaction partners:
- Cell division control protein 42 homolog
- Rho guanine nucleotide exchange factor 6
- Rho-related GTP-binding protein RhoU
- Ras-related C3 botulinum toxin substrate 2
- SH2/SH3 adapter protein Nck1
- Rho guanine nucleotide exchange factor 7
- Ras-related C3 botulinum toxin substrate 3
- LIM domain kinase 1
- Cytoplasmic protein NCK2
- Dual specificity mitogen-activated protein kinase kinase 1
Sequence:
MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLIDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRESPPPPARAHQENGMLEERAAPARMAPDKAGSRARATGHSEAGSGSGDRRRVGPEKRPKSSRDGPGGPQEASRDKRPLSGPDVSTPQPGSLTSGTKLAAGRPFNTYPRADTDHPPRGAQGEPHTMAPNGPSATGLAAPQSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLMRQHRTR
Protein: Protein Wnt-7b (P56706)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Frizzled-4
- Low-density lipoprotein receptor-related protein 5
- Frizzled-7
- Frizzled-10
- Secreted frizzled-related protein 1
- Frizzled-2
- Protein-serine O-palmitoleoyltransferase porcupine
- Low-density lipoprotein receptor-related protein 6
- Frizzled-9
- Frizzled-1
Sequence:
MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK
Protein: glucan 1,3-beta-glucosidase (EC 3.2.1.58) (Exo-1,3-beta-glucanase) (Q4WSV9)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Probable glucan endo-1,3-beta-glucosidase eglC
- Probable glucan 1,3-beta-glucosidase A
- Probable glucan 1,3-beta-glucosidase D
- 1,3-beta-glucan synthase
- Exo-beta-1,3-glucanase, putative
- Exo-beta-1,3-glucanase Exg0
- Beta-fructofuranosidase, putative
- Exo-beta-1,3-glucanase, putative
- Exo-beta-1,3-glucanase, putative
- Exo-beta-1,3-glucanase, putative
Sequence:
MRVSTLLPLALAAGTAAASKNGTLGFALGNKNEGGKCKVQSDYETDFDTLKEVTSLVRIYSASDCDTAKHIIPAAKAKNFKVVLGVWPDYDKSFTDDFNALKEAVPGNEEVIDAITVGSEVLYRKSLTPQALLARIQQVQKEFPKITVGMVDSWNKFADGTADPIIQGGVTYFLANGFAYWQGQELSNATNTYFDDMAQALGHIEQVAGSNADKIRFGNGETGWPTTGGTNYGPAVASTANAADYYKSAVCGMLAWGVDVFYFEAFDESWKPKTKGDNGEMQDETHWGAFTADRKAKFDLTCPKH
Protein: Uncharacterized protein YbjC (P46119)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Oxygen-insensitive NADPH nitroreductase
- Ribosomal protein bS6--L-glutamate ligase
- Multiple antibiotic resistance protein MarA
- Uncharacterized protein YbjN
Sequence:
MRAIGKLPKGVLILEFIGMMLLAVALLSVSDSLSLPEPFSRPEVQILMIFLGVLLMLPAAVVVILQVAKRLAPQLMNRPPQYSRSEREKDNDANH