Protein: Polycystin-2 (Curly up) (Cup) (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2) (Q6IVV8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By similarity). Required for normal temporal variation of the intracellular Ca(2+) levels in the heart. Plays a role in fluid-flow mechanosensation (By similarity). Required for normal specification of the body left-right axis during embryogenesis, most likely via its role in ciliary Ca(2+) oscillations in Kupffer's vesicle.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:16943304}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13563}. Cell membrane, sarcolemma {ECO:0000269|PubMed:16943304}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:16943304}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:23376035}. Apical cell membrane {ECO:0000269|PubMed:16943304}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13563}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:26432887}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13563}. Cell projection, cilium {ECO:0000269|PubMed:16943304, ECO:0000269|PubMed:26432887}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26432887}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16943304}. Note=Detected at the basolateral cell membrane and on apical, lumenal cilia in anterior, proximal pronephric ducts, and in intracellular vesicles in the posterior part of the pronephric duct. Detected on apical cell membranes on epithelial cells in the ear. {ECO:0000269|PubMed:16943304}.
Interaction partners:
- Polycystic kidney disease 1b.
- Exocyst complex component 5
- Polycystic kidney disease 1a.
- Transient receptor potential cation channel, subfamily C, member 1
- Transient receptor potential cation channel, subfamily V, member 4.
- Intraflagellar transport protein 20 homolog
- small monomeric GTPase
- Intraflagellar transport 88 homolog.
- ADP-ribosylation factor-like protein 13B
- Inversin
Sequence:
MSSSRVRPQAPQSPAASASASPPPHEGIEMEKMHHEEVGLGVPDETPSSPPTSSSRQAWSRDNPGFEPEEGMMEADWPPESQGRRSVSTTSSSSSGGVPGNFSGISARINRGLYPTPPAQEHRSCGKRILEKMRVLWDTRLLGESNSNREMYLKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFLDTPLSSGEPTNFKSLSTMEDFWKFTEGPFLNGMYWELWYNNKSLPENQSLIYYENLLLGVPRLRQLRVRNESCSVHEDLRDEVYDCYNVYSPANEDKAPFGPKNGTAWRFKDESSLGESSYWGQVSTYGGGGYYQDLSRTREKSANQLQELKNNLWLDRGTRAVFLDFSIYNGNVNLFCIVRLLVEFPATGGAVPSWQFQTVRLLRYVSSWDYFVGMCEVSFCLFVLYYLVEEALEIRLHRLRYFKSLWNCLDVLIVALSVPAIIMNICRTSAVSHRLHFLLENHSTYPNFEPLARLQVHFNNLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVFGTQVNDFSTFQACIFTQFRIILGDFDFSEIEEADSVLGPIYFTTFVFFIFMILLNMFLAIINDTYSEVKADMAQQRSEMEITDLIKKSYNRAMVKLKLKKSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAKYDLDGDQELTEHEHQQMRDDLEKEREDLDLEHSSLPRPASGRSFSRSQDDSEEDDDEDSGHSSRRRGSSSGGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEAMERAKMKRRDVLGRILDGVMEDERMGRDPELQREQMDRLVRDELERWESDDTMSQVSHHHHQATPIISSAQLRPRSSRPPSSLSNEGPDAAASGPAHL