wanglab/gogpt-training-data huggingface dataset:
Protein: Solute carrier organic anion transporter family member 1A4 (Brain digoxin carrier protein) (Brain-specific organic anion transporter) (OATP-B1) (Sodium-independent organic anion-transporting polypeptide 2) (Solute carrier family 21 member 5) (O35913)
Organism: Rattus norvegicus (Rat)
Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, prostaglandin E2, estrone 3-sulfate, L-thyroxine (T4), the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides. Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Hepatic sodium/bile acid cotransporter
- Bile salt export pump
- ATP-binding cassette sub-family C member 2
- Solute carrier family 22 member 7
- ATP-binding cassette sub-family C member 3
- Organic anion transporter 3
- Cytochrome P450 3A1
- Nuclear receptor subfamily 1 group I member 2
Sequence:
MGKSEKRVATHGVRCFAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSIVGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMGQYEYETILPTSNVSSNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEKRGITKDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPPICLGYLIGGLIMKKFKVTVKKAAHLAFWLCLSEYLLSFLSYVMTCDNFPVAGLTTSYEGVQHQLYVENKVLADCNTRCNCSTNTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIQSSGNSSAVLGLCNKGPDCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKSEEKSLGVGLHAFCIRILAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRLYLGLPAALRGASFVPAFFILRLTRTFQFPGDIESSKTDHAEMKLTLKESECTEVLRSKVTED
Protein: Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (RNA polymerase II alpha initiation factor) (P62915)
Organism: Mus musculus (Mouse)
Function: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q00403}. Chromosome {ECO:0000250|UniProtKB:Q00403}. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis. Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle. {ECO:0000250|UniProtKB:Q00403}.
Interaction partners:
- TATA-box-binding protein
- DNA-directed RNA polymerase II subunit RPB1
- General transcription factor IIF subunit 1
- General transcription factor IIF subunit 2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- General transcription factor IIE subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- DNA-directed RNA polymerase II subunit RPB4
Sequence:
MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPSDFKFDTPVDKLPQL
Protein: ATP-dependent DNA helicase 2 subunit 1 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit dp70) (ATP-dependent helicase Irbp) (Inverted repeat-binding protein) (Yolk protein factor 1 subunit beta) (Q23976)
Organism: Drosophila melanogaster (Fruit fly)
Function: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- ATP-dependent DNA helicase II subunit 2
- DNA ligase 4
- Double-strand break repair protein
- RecQ-like DNA helicase Blm
- DNA repair protein RAD50
- Replication protein A 70 kDa DNA-binding subunit
- Aprataxin and PNK-like factor
- Exonuclease 1
- Poly [ADP-ribose] polymerase
- LD28027p
Sequence:
MSTWNPENDVDLLSGSEDEEDVSMKRDYHGREAILFVVDANLQTAGVERLLEALNIIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYLEFMGGVETQFADVYGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVREPHPSNSNHFQAALQKASDLEGKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQMLREILSDRKLKQDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTKRVITVQKQKDDGSQDIEHEYQIKVTGGWYTCNVGERDLRISMDQLNRVRNLHKPQMMLLGFKHRSSLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVALVPVEAPDNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTENTADEQKVEFFQKIIKKLRVDYQPNLINDPSLDALQANLLALSLDFSTDTKGLDNLLDTSQQDKRIEKLLPDYEMFAPEAEPHKKRAAKSTTAGASGPKMAKIDDDQLKEFEFVKSLNKDEALTSCTAAQLHFILQHHFDVTMPKSSKKAKLVAKIEELHK
Protein: Protein EARLY STARVATION 1, chloroplastic (MpESV1) (A0A2R6W1B1)
Organism: Marchantia polymorpha (Common liverwort) (Marchantia aquatica)
Function: Binds preferentially to highly ordered alpha-glucans, such as starch and crystalline maltodextrins (By similarity). Involved in the organization of the starch granule matrix, thus influencing starch turnover by modulating the accessibility of starch polymers to modifying and degrading enzymes. Required for the control of starch degradation in leaves and starch distribution in nonphotosynthetic parts. Promotes gravitropic responses, negative in shoots but positive in roots, by facilitating starch granules (statoliths) formation in hypocotyls and roots columella.
Subcellular location: Plastid, chloroplast stroma {ECO:0000250|UniProtKB:F4I9G2}. Note=Binds to starch granules in chloroplasts. {ECO:0000250|UniProtKB:F4I9G2}.
Interaction partners:
Sequence:
MALDVLGRLGFFNCGSGSVVTPCSASARLSSELEPSKQRNRSWFRSPGSGGSTWAVANILCFDKDTIPESFRNGRLRSRARQKTLLEGASRSSLSSAARLWISKTAGIPSSRTGCRGSVLNGGWSGGEVAGEGRKSLLPIKRHSSCSSQSLPQQQRRTKDAGRVVCYSHRKRNLGSLLGSRVVEEPWSWILEGYVLKGLTGRRNDGPSELELGRGSYRGGPVHGANHIRPLQRPDSVHPQPLTSARPRRGTEHDELPLRRTLRNCIPHSRDTPPKRDTGIASEKDWGINLKNEKTSESGVNEDGSTWYRESGEDLGDNGYRCRWTVMGGKNADGTSEWKEAWWEKSDWTGYKELGAEKSGKNAQGDTWWETWQEILRQDDWSNLARIEKSAQKQAKSGSGTAGWYEKWWEKYNAKGWSEKGAHKYGRLNDQGWWEKWGEQYDGRGAVLKWTDKWAETDMGTKWGDKWEERFNVGIGTRQGETWHYSATGERWSRTWGEEHFGNGKVHKYGKSTSGESWDSVVEEGTFYQAEPHYGWADAVGNSGQLLSIVALERPPGIYPDLDLGMNKEQQ
Protein: Epsilon 3 globin (Globin b2) (Hemoglobin subunit gamma 1) (Hemoglobin, gamma A) (O88754)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Hemoglobin subunit zeta
- Globin b1
- Globin c1
- Hemoglobin alpha, adult chain 2
- Hemoglobin subunit beta-1
- Hemoglobin subunit alpha-1/2
- Apolipoprotein E
- Protein Z-dependent protease inhibitor
Sequence:
MVHFTAEEKAAIISIWEKVDLEKIGGETLGRLLIVYPWTQRFFDKFGNLSSALAIMGNPRIRAHGKKVLTSLGSAVENMDNLKETFAHLSELHCDKLHVDPQNFKLLGNMLVIVLSTHFAKEFTPEVQAAWQKLVMGVANALSHKYH
Protein: Tetraspanin-2 (Tspan-2) (Tetraspan NET-3) (O60636)
Organism: Homo sapiens (Human)
Function: May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- CD63 antigen
Sequence:
MGRFRGGLRCIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGAIKELSSEDKSPEYFYVGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKGVAIRHVQTMYEEAYNDYLKDRGKGNGTLITFHSTFQCCGKESSEQVQPTCPKELLGHKNCIDEIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRNSRDVI
Protein: Glutathione S-transferase omega (GSTO) (EC 1.20.4.2) (EC 1.8.5.1) (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (Monomethylarsonic acid reductase) (C1BFQ9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MASEKCFAKGSSAPGLVAKGQIRLYSMRFCPFAHRTRLVLHAKGIKHDTVNINLKDKPEWFLKKNPLGLVPTLETSSGQVIYESPITCDYLDEVYTDKKLLPADPFQKAQQKMMLENFSKVTPYFYKIPMGKKNGEDISVLEGELKEKFVKLSEDLVNKKFFGGNAITMIDYMMWPWFERLEIFELKHCLDGTPELKKWTEHMSEDQTVKATMFPTETYKAFYKTYADGKPNYDYGL
Protein: At2g15240/F15A23.2 (Expressed protein) (UNC-50 family protein) (Q9SKL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLPTTSRSRSSSSSSRANPMFLQYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLLVVATVAYCVTYDHSSSHAVVVVVSVLFTHFLITGAVIATCCWFLTNSYLREETPNSHVVEQRVEWLYTFDVHCNSFFPMFVLLYVVHYFLSPLLIAHGFIPLLLSNLLFMVGASYYHYLNFLGYDVLPFLERTTFFLYPIGVVIVLSPILILSGFNPSRYFMNMYFSQRL
Protein: Uncharacterized protein (Q383V3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cleavage and polyadenylation specificity factor 30 kDa subunit
- Cleavage and polyadenylation specificity factor subunit, putative
- Suppressor of forked domain-containing protein
- C3H1-type domain-containing protein
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor-like protein, putative
Sequence:
MSSPYQRKITISAGEECTLSGSCVVGLQLLSGVVEVAGVLLKAKEPPTFRLLTDRYSLVMYTLEGGCVLATSTKQFEVSKAATGMASVGQLCRGALATVTRSKVLVIGRRASGKTLTAHTICNILREDASAVELGAASTSVFLMDLNAESNSIYAPGCISTVLVEHILWPDTSASPTLLPFSLFVGETAPPGNESVASFLSFVEQLNECTDALIGAANTERAHVVIDAPSPQEGVMEGVYFRRLVELLRPTHVVMVSTQGESDLCSNVLQEDIQRVLPECDVSYVAPVSQRCNSSVREQRLCGYFSGNPQCPLACAKIVLPLAQVQLVRYVRSESGVTCSKVTPSATIIGCICAVSHAEVIEEVPLAPIAGLLLLFAIDEEHEELVAVVPASEPLPRRFLILPNEPTRSCPPSALFSGEVAAHVEEAVAI
Protein: Ras-related protein Rab-2A (EC 3.6.5.2) (P36409)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
Sequence:
MYSFLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDNKAIKLQIWDTAGQESFRSITRSYYRGSAGALLVYDITRRDTFNHLTCWLKDARSYANSNMTIILIGNKSDMESKRAVSYEEGRQFADENGLIFLETSAKTASNVEEAFVNTASKIYEKIQKGDFDINNESFGIKLGAPTSKQDGTDQKPAGGGCCK
Protein: Neuroblastoma suppressor of tumorigenicity 1 (Cysteine knot secreted protein DAN) (cDAN) (Q90YC9)
Organism: Gallus gallus (Chicken)
Function: May act as a tumor suppressor.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Bone morphogenetic protein 2
- Bone morphogenetic protein 7.
- Bone morphogenetic protein 4
- Bone morphogenetic protein 6.
- Growth/differentiation factor 5
- TGF_BETA_2 domain-containing protein.
- Growth differentiation factor 6
- TGF_BETA_2 domain-containing protein.
- Growth differentiation factor 7.
- BMP5
Sequence:
MLWFVVGALFPALLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCESKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLDCPGNDEIPRVDKLVEKILHCSCQACGKEPSHEGALFNVYLNAEENMPAEGPGPHHYAHHQQEVEEPPASSHHHHEEEGDE
Protein: Protein AIG2 A (EC 2.3.2.-) (Avirulence-induced gene 2 protein) (Avirulence-induced gene 2 protein A) (AvrRpt2-induced gene 2) (Protein AIG2) (Putative gamma-glutamylcyclotransferase) (P54121)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative gamma-glutamylcyclotransferase.
Interaction partners:
- CAP superfamily protein
- Probable carboxylesterase 3
- Immune-associated nucleotide-binding protein 8
Sequence:
MTSSDQSPSHDVFVYGSFQEPAVVNLILECAPVMVSAQLHGYHLYRLKGRLHPCISPSDNGLINGKILTGLTDSQLESLDMIEGTEYVRKTVEVVLTDTLEKKQVETIVWANKDDPNMYGEWDFEEWKRLHMEKFIEAATKFMEWKKNPNGRSREEFEKFVQDDSSPASA
Protein: Tumor necrosis factor receptor superfamily member 22 (Decoy TRAIL receptor 2) (TNF receptor family member SOBa) (TNF receptor homolog 2) (Tumor necrosis factor receptor p60 homolog 2) (Q9ER62)
Organism: Mus musculus (Mouse)
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MFGFFCSLVSSLSRWFLWRRLLLLLLLLLLNLPLQVKFAMLELHSFKCPAGEYWSKDVCCKNCSAGTFVKAPCEIPHTQGQCEKCHPGTFTEKDNYLDACILCSTCDKDQEMVADCSATSDRKCQCRTGLYYYDPKFPESCRPCTKCPQGIPVLQECNSTANTVCSSSVSNPRNRLFLLLSPLSVLIVSVVVFRIIRR
Protein: Inosine-5'-monophosphate dehydrogenase 3 (IMP dehydrogenase 3) (IMPD 3) (IMPDH 3) (EC 1.1.1.205) (P50095)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Inosine-5'-monophosphate dehydrogenase 4
- GMP synthase
- Inner kinetochore subunit NKP2
- Protein NAM8
- Adenylosuccinate synthetase
- Inosine-5'-monophosphate dehydrogenase 2
- Bifunctional purine biosynthesis protein ADE16
- Bifunctional purine biosynthesis protein ADE17
- AMP deaminase
- Hypoxanthine-guanine phosphoribosyltransferase
Sequence:
MAAVRDYKTALEFAKSLPRLDGLSVQELMDSKTRGGLTYNDFLVLPGLVDFPSSEVSLQTKLTRNITLNTPFVSSPMDTVTESEMAIFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKERFGFSGFPVTEDGKRNGKLMGIVTSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGKLLIVDDNGNLVSMLSRTDLMKNQNYPLASKSATTKQLLCGAAIGTIDADKERLRLLVEAGLDVVILDSSQGNSIFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVCEFANQFGIPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGYKSLTLLKENVQSGKVRFEFRTASAQLEGGVHNLHSYEKRLHN
Protein: Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (B0QYD3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQVRASSLCLVPHRPPPPPRSPVPCLPLCSEPPLGSLLPTGRPAPSLPFLLTASFSFPPPASLPPLPSLSLSPGHLPVPSFHSLTSCSIQPPCSSRIRETEGWASVSKEGRDLG
Protein: Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) (Q642A2)
Organism: Rattus norvegicus (Rat)
Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. {ECO:0000250}.
Interaction partners:
- Angiotensinogen
- Type-1 angiotensin II receptor A
- Type-1 angiotensin II receptor B
- Renin
- Angiotensin-converting enzyme
- Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Sequence:
MELPAVNLKVILLVHWLLTTWGCLAFSGSYAWGNFTILALGVWAVAQRDSVDAIGMFLGGLVATIFLDIIYISIFYSSVAVGDTGRFSAGMAIFSLLLKPFSCCLVYHMHRERGGELPLRSDFFGPSQEHSAYQTIDSSDSPADPLASLENKGQAAPRGY
Protein: RNA polymerase II holoenzyme cyclin-like subunit (Suppressor of RNA polymerase B srb11) (O94503)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Cdk8 module/Srb8-11 module which is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Serine/threonine-protein kinase srb10
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 13
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 31
Sequence:
MAANYWASSQLTQLFLSTDLESLEPTCLSKDTIYQWKVVQTFGDRLRLRQRVLATAIVLLRRYMLKKNEEKGFSLEALVATCIYLSCKVEECPVHIRTICNEANDLWSLKVKLSRSNISEIEFEIISVLDAFLIVHHPYTSLEQAFHDGIINQKQLEFAWSIVNDSYASSLCLMAHPHQLAYAALLISCCNDENTIPKLLDLIKSTDAFKVILCVQRIISIYYFEDIE
Protein: B2 bradykinin receptor (B2R) (BK-2 receptor) (P25023)
Organism: Rattus norvegicus (Rat)
Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30411}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Kininogen-1
- Guanine nucleotide-binding protein G
- Angiotensinogen
- B1 bradykinin receptor
- Endothelin-1
- Guanine nucleotide-binding protein subunit alpha-11
- Prothrombin
- Guanine nucleotide-binding protein subunit alpha-15
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
Protein: Small ribosomal subunit protein uS8 (40S ribosomal protein S15a) (P62245)
Organism: Mus musculus (Mouse)
Function: Structural component of the ribosome. Required for proper erythropoiesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62244}.
Interaction partners:
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein eS10
Sequence:
MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF
Protein: HTH-type transcriptional repressor CytR (P0ACN7)
Organism: Escherichia coli (strain K12)
Function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors.
Interaction partners:
- DNA-binding transcriptional dual regulator CRP
- Uridine phosphorylase
- Protein Sxy
- Deoxyribose operon repressor
- Deoxyribose-phosphate aldolase
Sequence:
MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALRRCGIMVDPQYIARGDFTFEAGSKAMQQLLDLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP
Protein: Nucleotide binding protein-like isoform A (X5D2R5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSPSE
Protein: Hepatocyte growth factor receptor (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (Tyrosine-protein kinase Met) (F1QLR7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Hepatocyte growth factor
- Hepatocyte growth factor
- Catenin beta-1
- Cbl proto-oncogene, E3 ubiquitin protein ligase.
- GRB2-associated-binding protein 1
- Protein tyrosine kinase 2ab
- Plexin-B1
- Growth factor receptor-bound protein 2
- Catenin, beta 2.
- Catenin
Sequence:
MTIHYSEAASILIILQSLWWGLNCQCEEPIESSKLDLSVTYDLPYFVSDTPIQKLLEINGTVYVGAVNRLYALSKDLKKKHEYKTGPVHEGPDCKTPTDQCSGCENKPRNINNTNMALLMETFYDLELFSCGSVGNGVCSRHVLEDGPLGAEVTCMYTKKNEGSSHGCPDCLAGPAGTQILNIMSGRVVRFFVANSEPLESNGPRLHHTISIRKMRETQDGFEFFSDQSYMDLAPSLRGNYPLHYVYSFQSGPYVYFLTVQREGGNSKAFHTRIVRMCSSDSEILRYVEMPFECIYSERRRKKRSAQVVFNVLQAAHVAKVGYDFQQEMGLKEGEDVLFAAFARSKPDSPEPTASSAVCLISITDINEFFKVFIQKGYTRKLHHFPGSEEKTFNQTFVGDSFSCGKHERGYRLEVTSTNPRRDYFHGRFRNVLLTSIAVVPIQNHTVVSLGTAEGRVIQVVVSRFGKTEPHVDFRLDTLPVSSEMALLSPQHHNGSLLLITGNKVSKLPVIGPGCEQLWTCSSCLLAPGFMGCGWCRTSNLCTRAPRCPQSQWIQDSCPLLITSISPSSAPLRGQTNITICGKNFGFNKKDRFDTKLIDVVVAGTKCKLERKDSNNNRLVCGLDHVNWSSVDSVVTVRSGKEQAQKDGFSFVNPVIIEIFPEFGPQSGGTMLTISGSFLDSGNVQTVTVGNATCVLQSVSATMLTCRTPPQPSPSQHKVQLHIDGVIFEAPVSYTYNKNPHISSVQPKHSFISGGSTVTVNGFYLHSALQPQMVLTAATEGKLFQVTCSHDEDKRNILCITPSLKGLSVQPPVATKMTFVLDGFSTDQYDLLYVEDPKFEEFQKPTVTPRGKKNILEIKVPPVNQEAVKNGEVLRVSNRTCESVTLVGNTLECTVPMELQTAAKELEVEWKQATSSVILGRVILAQDQDYRILITGGVCVSILLLLLIAVFVWIKRKKHINDLAKTMVWYDGRAHIPHLDMLANARSVSPTNEMVSHESVDYRTTLLEDQNLPLSQTESCRPHLYAHSHVDLSPMLGPMEGDLASPLLPSTAPIDLGSLHPELLKEVQHVVIAREDLLLHVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIMKDFSHPNVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRDESHNPTVKDLMGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKHGVKLPVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVMIECWHPKPERRPTFSELVSRISAIFSSFSGEHYILLNTTYVNIDKMTPYPSLISSQSNLDRDCCT