wanglab/gogpt-training-data huggingface dataset:
Protein: Inactive deaminase YJL070C (P40361)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- AMP deaminase
- Inactive deaminase YBR284W
- IME2-dependent-signaling protein
Sequence:
MQAVERRPSLLFDEYQNSVTKPNETKNKEARVLSENDGDVSPSVLKQKEISVDDMDMISLPTEFDRQMVLGSPMFFDLEDEENKIDPLPSVSHHYGNGESDSFVSSYTPSNLKTGEETKDLFINPFELVSQMRKRYIAASKQDGISNIKNDTEKWFLYPKPLPKFWRFEDDKRFQDPSDSDLNDDGDSTGTGAATPHRHGYYYPSYFTDHYYYYTKSGLKGKGNIKVPYTGEYFDLEDYKKQYIYHLSNQENTQNPLSPYSSKEESLEEEFLTDVPTFQEFRDDFAYIIELIQSHKFNEVSRKRLSYLLDKFELFQYLNSKKEILANKNVPYRDFYNSRKVDRDLSLSGCISQRQLSEYIWEKINLEPERIVYQDPETSRKLSLRDIFQFGCSSNDQPIAIGLKLIDDEFLDWYRNIYLIDYHLTPNKVAKLVGKEMRFYLLAKVFLEFDNFIEGEYLAEIFIKYVIHILEKSKYQLAQVSVNFQFYSSGEDWYKKFSQWLLRWKLVSYNIRWNIQIARIFPKLFKENVVSNFQEFLDLIFNPLFTLEKEQLPIDSSVNTDIIGLQFFLSNVCSMDLVIKESDEYYWKEFTDMNCKPKFWTAQGDNPTVAHYMYYIYKSLAKVNFLRSQNLQNTITLRNYCSPLSSRTSQFGVDLYFTDQVESLVCNLLLCNGGLLQVEPLWDTATMIQYLFYLFQIPILAAPLSSVSLLNSQKSTFLKNKNVLLEHDYLKDQETAKINPSRDITVGEQRSYETNPFMKMFKMGLKISLSSKSILYNSSYTLEPLIEEYSVAASIYLLNPTDLCELSRTSVLSSGYEGWYKAHWIGVGVKKAPYFEENVGGIDNWYDTAKDTSIKHNVPMIRRRYRKETLDQEWNFVRDHFGVINSIW
Protein: Uveal autoantigen with coiled-coil domains and ankyrin repeats (F5H2B9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC
Protein: N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) (F4JTK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Ornithine transcarbamylase, chloroplastic
- Arginine biosynthesis bifunctional protein ArgJ
- Acetylornithine aminotransferase, chloroplastic/mitochondrial
- Acetylornithine deacetylase
- Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
- Arginase 1, mitochondrial
- Arginase 2, chloroplastic/mitochondrial
- Aminoacylase, putative
- At1g44820
- Argininosuccinate synthase, chloroplastic
Sequence:
MSLLRLLLVVVVLHLSAVAGDDAIVSRFQEYLRINTVQPNPEYYKAVDFIISQAKPLSLESQTIEFVKGKPLLLLKWVGSDPTLPAFLLNSHTDVVPFEDSKWTHHPLQAHMDHHGDIYARGSQDMKCVGMQYLEAIRKLQASGFKPLRSVYLSFVPDEEIGGHDGAEKFAESQLFKSLNIAIVLDEGLPSPTESYRVFYGERSPWWLVIKAKGPPGHGAKLYDNSAMENLLKSIESIRRFRASQFDLLKAGGIAEGDVVSVNMAFLKAGTPSPTGFVMNLQPSEAEAGFDIRVPPSVDAEALERRLVEEWAPAARNMSFELGQFKQKLTGKQFLTAADDSNPWWGLLENAVKEAGGRTSKPEIFPASTDARYFRKAGVPAFGFSPISNTPSLLHDHNEYLGKAEYLKGIEVYVSIIKAYASYESKSGSRDEL
Protein: Coiled-coil domain-containing protein 9 (Q9Y3X0)
Organism: Homo sapiens (Human)
Function: Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation.
Interaction partners:
- Eukaryotic initiation factor 4A-III
- Protein mago nashi homolog
- RNA-binding protein 8A
- Protein CASC3
- Regulator of nonsense transcripts 1
- Regulator of nonsense transcripts 2
- Regulator of nonsense transcripts 3B
- Partner of Y14 and mago
- Regulator of nonsense transcripts 3A
- Protein mago nashi homolog 2
Sequence:
MAATLDLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWPFESV
Protein: Centrin-2 (Caltractin isoform 1) (Q9R1K9)
Organism: Mus musculus (Mouse)
Function: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P41208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:11250075}. Nucleus {ECO:0000250|UniProtKB:P41208}. Nucleus envelope {ECO:0000250|UniProtKB:P41208}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P41208}. Note=Localizes to the inner scaffold in the central region of centrioles and to the distal end of centrioles. {ECO:0000250|UniProtKB:P41208}.
Interaction partners:
- UV excision repair protein RAD23 homolog B
- PCI domain-containing protein 2
- Germinal-center associated nuclear protein
- Transcription and mRNA export factor ENY2
- DNA repair protein complementing XP-C cells homolog
- UV excision repair protein RAD23 homolog A
- Serine/threonine-protein kinase PLK1
- DNA excision repair protein ERCC-1
- Nuclear pore complex protein Nup153
- DNA excision repair protein ERCC-8
Sequence:
MASNFKKTTMASSAQRKRMSPKPELTEDQKQEIREAFDLFDADGTGTIDIKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFSDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEQEFLRIMKKTSLY
Protein: BcDNA.LD27979 (Q7KK29)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, P-body {ECO:0000256|ARBA:ARBA00004201}.
Interaction partners:
Sequence:
MVRLGGNGERVRKRPAESSGNTDFADQGNGAFLRHANPLSSAPSSSGSTPAPLNAPFRQSRHIGDSDLELNISSMKLDDMDLSSFTTDSEAGGLSNRIKLDSGVWGSQPFPNNQHLFREPMRSAFKPQQQQHQQHQPQQMKPPQEANANFALNPQPFPKITTLEDIERNMIIQQAIPKQQQQSQQQAERKMFDDFSLGNRQQVPTPTMLQQQMLQQQHHQKQQSQQQPPQQAQHKVPPGFLGTPHTSPPRPNLGFPGPELLPTPSSQQQLNGIGGNRVPPGFIYPQGLPGNIPQLPQHPLMQQHMPHNFPLPGGNQRPLPNPQALPTALNNFAMHPSFNAMRAAGIHPGAFMQPPHPHQMLPPRMPPHPLQAATSLLGQQPPNSMYNMFNMRLVQEIQQNHPLLQQAAVVRQMQQSRAGSVASDRQRSQAQQQQQGRRPDGTGNYPLEEYDEYANLMSTRDKHWLIGIQLSQLNTDTPYIDDYYYTVFRERKAQQNGQMRNSQAHKDNQLNHPLTQPRGHAQLILVQLGNKNGTRNGHGRERRNSENTNSTSGNTNNGSGGNNNNLTGYIFSPLKFENSLGKLQYGSVTAPRKIIDADIMSGESNAAAEANATSSSKSSTPLPTSASHDVNPSSMRKSRHILLLIETLYRYLLKLEDLESPEVMATIELKKKKEAERIAALEQLEMANKTPEERAAEAANPQTMNPQLKNKFNYEVETKAALVNKLKAGLAFDKVIAMMNVRKGKILIRRIMPFIADQSIRWVVWSGVFCSLQTVVKKDKDDVEGVLYALYPEFKKHVNKATFELLVSISSAITLNDKKLAGIFCSRFGILSLVALILRAEEIYVSRTDATLSEENRQKWREFLAQVASCLNRTIQNQTISAAIESDAIQPLMDHFERFKDLKLDALLALITEARHQID
Protein: Serpin domain-containing protein (O17365)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSDNATSQTDFALKLLATLPHSGSVVLSPLSISLGLALIHAGACGSTQKELEDVLGGSRIFEEFSGLMEAVGDTDNGVETKIVNRVFVNQAYTIHQDYLETVEKLYKASGESLDFSQTEQAAKTMNTFVENHTNGKIKDLIPADSANNAFAFLVNAMYFKADWQSKFAKESTTGREFFTSEAESRQIPFLTELDEHRDYTEDVLFQVLSLKYADPKFTLAIFLPKQRFGLVDALEKINGEYIQNLLNDLKSSYVSVQIPKFKIEKELDLKETLEAIGIKEIFAEGADLSGIADKVFISSGIHKAIIEVDEDGTTAAAASAFKVQLEMMIMAEPTQFVADHPFLFAVLFENHTLFLGVHA
Protein: Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4) (Q9CWX4)
Organism: Mus musculus (Mouse)
Function: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q96CM3}. Nucleus {ECO:0000250|UniProtKB:Q96CM3}. Cytoplasm {ECO:0000250|UniProtKB:Q96CM3}. Note=Mainly localizes to mitochondrion. Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Also found in nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q96CM3}.
Interaction partners:
- Neugrin
- Mitochondrial assembly of ribosomal large subunit protein 1
- rRNA methyltransferase 3, mitochondrial
- FAST kinase domain-containing protein 2
- Pseudouridylate synthase TRUB2, mitochondrial
- rRNA methyltransferase 1, mitochondrial
- Probable ATP-dependent RNA helicase DDX28
- Pseudouridylate synthase PUS7L
- Mitochondrial ribosome-associated GTPase 1
- Pseudouridylate synthase 1 homolog
Sequence:
MAAPCLRTPGVQLLSMSSRPGRLFTPGSWSFCSSATSSRPLNAQRLAEKLRAQKQEQKAKEVRVPTNPVQRRVQELVRFTQQLQRVHPNVLAKELSRRILHQDNDLVVINKPYGLPVHGGPGVQLCISDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWEKDMAHQVQELFRTRQVEKKYWAITVRVPLPSAGVVDIPIKEKEVQGPQQHHKMTLSPSYRLDNGKMVKVRASRDAHVAVTQYQVLSSASSSALVELQPVTGIKHQLRVHLSFGLDCPILGDHKYSDWTRLAPQKLSAGTLKKLGLQQSKARYIPLHLHARQLILPALGSRTEELLLTCKLPHFFARSLLRLGLDMPNQDQSRGNKARHVEAR
Protein: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) (E9QE09)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Aldose 1-epimerase
- UDP-glucose 4-epimerase
- Galactokinase 1.
- N-acetylgalactosamine kinase
- UTP--glucose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Phosphoglucomutase 1
- Phosphoglucomutase 5
- Phosphoacetylglucosamine mutase
- UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1.
Sequence:
MDMNNKPTFDPKEHQHLRYNPLRDSWVLVSAHRMKRPWKGQVEKPPEDNIPRHDPNNPLCPGSVRANGELNPEYDSTFMFDNDFPALQPDAPDPGSDHHPLFQSKAARGVCKVMCFHPWSDITLPLMQPAEIRKVIDKWADLTVELGATYAWVQIFENKGAMMGCSNPHPHCQVWASNFLPNEASLAERCQRDFLQKHGEPMLVQYARMEAQAQERVVVENEHWLVVVPYWATWPFQTLLLPRRHVLRLPDLTTQERDSLASIMKRLLTKYDNLFEVSFPYSMGWHGAPTGSHLNKNMSHWQLHAHYYPPLLRSANIRKFMVGYEMLANEQRDLTPEQAAEQLRKLSEEHYKVKKAEGKSGVEN
Protein: CALM3 protein (Q9BRL5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDESLSMPLISSFCPRLFHPCLPRPDAFIS
Protein: Meiotic recombination protein DMC1/LIM15 homolog (Q61880)
Organism: Mus musculus (Mouse)
Function: Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Subcellular location: Nucleus {ECO:0000269|PubMed:21307306}. Chromosome {ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22549958, ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:30949703, ECO:0000269|PubMed:32463460}.
Interaction partners:
- Breast cancer type 2 susceptibility protein homolog
- DNA repair protein RAD51 homolog 1
- Meiotic recombination protein SPO11
- Homologous-pairing protein 2 homolog
- Serine-protein kinase ATM
- Histone H2AX
- MutS protein homolog 4
- DNA repair protein RAD52 homolog
- DNA repair protein XRCC3
- Breast cancer type 1 susceptibility protein homolog
Sequence:
MKEDQVVQEESGFQDDEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGTGGYSGGKIIFIDTENTFRPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE
Protein: Splicing factor U2af small subunit B (U2 auxiliary factor 35 kDa subunit B) (U2 small nuclear ribonucleoprotein auxiliary factor small subunit B) (U2 snRNP auxiliary factor small subunit B) (Zinc finger CCCH domain-containing protein 60) (AtC3H60) (Q9FMY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for the splicing of pre-mRNA (By similarity). Probably active at the 3' splice sites.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:16407443, ECO:0000269|PubMed:22563826}.
Interaction partners:
- Splicing factor U2af large subunit A
- RNA-binding
- Splicing factor U2af large subunit B
- Splicing factor U2af small subunit A
- U1 small nuclear ribonucleoprotein 70 kDa
- Serine/arginine-rich splicing factor SC35
- Serine/arginine-rich splicing factor SR45
- Zinc finger C-x8-C-x5-C-x3-H type family protein
- RNA-binding
- Nuclear protein-like
Sequence:
MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHNRPTISPTLLLSNMYQRPDMITPGVDPQGQPLDPSKIQDHFEDFYEDIFEELNKFGEVESLNVCDNLADHMIGNVYVLFKEEDHAAAALQALQGRFYSGRPIIADFSPVTDFREATCRQYEENSCNRGGYCNFMHVKQISRELRRKLFGRYRRSYRRGSRSRSRSISPRRKREHSRERERGDVRDRDRHGNGKRSSDRSERHDRDGGGRRRHGSPKRSRSPRNVREGSEERRARIEQWNRERDEGV
Protein: Transcription initiation factor TFIID subunit 5 (TAFII-80) (Transcription initiation factor TFIID 85 kDa subunit) (p85) (P49846)
Organism: Drosophila melanogaster (Fruit fly)
Function: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery.
Subcellular location: Nucleus.
Interaction partners:
- Transcription initiation factor TFIID subunit 8
- IP01149p
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 6
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 4
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 11
Sequence:
MSLEVSNINGGNGTQLSHDKRELLCLLKLIKKYQLKSTEELLCQEANVSSVELSEISESDVQQVLGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDSFDAQHYEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLDGYYIEGLFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQEVVADIVSKYLHFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAPAPEEEDDDPDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKRLALSKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKDADSLRELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTLLRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDVYLMRTFPSKNSPFVSLHFTRRNLLMCVGLFKS
Protein: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) (P22682)
Organism: Mus musculus (Mouse)
Function: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Ubiquitinates SPRY2 (By similarity). Ubiquitinates EGFR (By similarity). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA.
Subcellular location: Cytoplasm. Cell membrane {ECO:0000250}. Cell projection, cilium {ECO:0000269|PubMed:29237719}. Golgi apparatus {ECO:0000269|PubMed:29237719}. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane. {ECO:0000250}.
Interaction partners:
- SH3 domain-containing kinase-binding protein 1
- Protein sprouty homolog 2
- Epidermal growth factor receptor
- Adapter molecule crk
- Crk-like protein
- Growth factor receptor-bound protein 2
- Hepatocyte growth factor receptor
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Proto-oncogene vav
- Tyrosine-protein kinase SYK
Sequence:
MAGNVKKSSGAGGGGSGGSGAGGLIGLMKDAFQPHHHHHHLSPHPPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVPASTSVLGTASKAASGSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSMTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRPLEATQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSASGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGATANPVATAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT
Protein: Syncrip, isoform A (Q8IN47)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNKFVSHNLGRDPYRTFSPEMYPLSSPLGPHGTEMAEGNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKEFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLDNHEIKPGKCLKINISVPNLRLFVGNIPKSKGKDEILEEFGKLTAGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGNLSPTHPSIMSLTPMRPGARMPLRTPIPREYVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPLGTNGEQWYMDTFSAWS
Protein: Plasmid partition protein A (P07620)
Organism: Escherichia coli
Function: This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. ParA is trans-acting.
Interaction partners:
Sequence:
MSDSSQLHKVAQRANRMLNVLTEQVQLQKDELHANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRYSEAYVIFISNLKGGVSKTVSTVSLAHAMRAHPHLLMEDLRILVIDLDPQSSATMFLSHKHSIGIVNATSAQAMLQNVSREELLEEFIVPSVVPGVDVMPASIDDAFIASDWRELCNEHLPGQNIHAVLKENVIDKLKSDYDFILVDSGPHLDAFLKNALASANILFTPLPPATVDFHSSLKYVARLPELVKLISDEGCECQLATNIGFMSKLSNKADHKYCHSLAKEVFGGDMLDVFLPRLDGFERCGESFDTVISANPATYVGSADALKNARIAAEDFAKAVFDRIEFIRSN
Protein: Double hit, isoform B (LD40005p) (Q8T017)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- G protein alpha i subunit subunit alpha 65A)
- G protein alpha o subunit subunit alpha 47A)
- G protein beta subunit 5
- Guanine nucleotide-binding protein subunit alpha
- Chaperone Ric-8
Sequence:
MSCTVSELPSGCRLRGMTASSQQSAANNSGNNGNGNGNGGGGGVVGGGGSLGGVSPTVGGSVGILGSTSNVLQESNATTFQRPQSQKPCCFCWCCCCSCSWAKCLAIKNADENAPTKRDLVNAEFLDGEQPTLEEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACEDLKKENSPELVEEKARLIYEDYISILSPREVSLDSRVREIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYPRFLNSQKFKTLAQLQDNSNAGSKADSPT
Protein: Meiosis protein 5 (P32489)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots.
Subcellular location: Nucleus {ECO:0000269|PubMed:15620352}.
Interaction partners:
- Pachytene arrest protein SAE3
- Meiotic recombination protein DMC1
- DNA repair protein RAD51
Sequence:
MHNQEEWLDKDKTLVNEEENTCINHSYTKKDTNNYRVGKSGIKDLKKPTNQKEIAIKNRELTKQLTLLRQENNHLQQACKILSENKIIENRKSIEKWRTICEMELSFILNSTLIKINRMGGYKDFLEKEMEAKKRRLEYQIDNGMEDQICEIKESDDFRQLSEVEKQEWESQMNEQLKELEKKKIAELEKLNKVLHDSEGKDFGMAELCTRLKLDYSLIFPQ
Protein: Probable metabolite transport protein YDR387C (Q04162)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Putative metabolite transport protein YDL199C
Sequence:
MSTDESEDVYSDLYSIISQVTSNTANDIEQLPYALTFKTSLIFVGATIGGLLFGYDTGVISGVLLSLKPEDLSLVVLTDVQKELITSSTSVGSFFGSILAFPLADRYGRRITLAICCSIFILAAIGMAIARTLTFLICGRLLVGIAVGVSAQCVPLFLSEISPSRIRGFMLTLNIIAITGGQLVSYVIASLMKEIDNSWRYLFALSAIPAILFLSILDFIPESPRWSISKGDILYTRDSLRMLYPTASTYHVNSKIKQLIIELDKLRLYEDASEPLLVQSQSVIRYMDSSTSGTLSPPNIKRLSSNTERTSNTMSSSSAYLSALRGPAPNGALASNKKKRHRMEPRTIRALIVGCMLMFFQQITGFNAFMYYAAIIFSKFNIKNPLLPPILIASTNFIFTFFAMYTMDSLGRRAILLRTILIMTVGLLLCSVGFGHDQVNLLLISVVIYVAAYASAMGSVPWTCVEFLPLNRRSFGASCIACTNWLTNAFVSMTYLSTINTIGDENTMLIFAFFTVCAWFFVYFWYPEVKGLSLEEVGRVFDNGIDVHYVFRTYH
Protein: Cellular tumor antigen p53 (Tumor suppressor p53) (P79734)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Protein Mdm4
- E3 ubiquitin-protein ligase Mdm2
- protein acetyllysine N-acetyltransferase
- non-specific serine/threonine protein kinase
- Checkpoint kinase 2.
- Apoptosis regulator Bcl-2
- histone acetyltransferase
- Serine/threonine-protein kinase CHK1
- Bcl-2-like protein 1
- CREB-binding protein b.
Sequence:
MAQNDSQEFAELWEKNLIIQPPGGGSCWDIINDEEYLPGSFDPNFFENVLEEQPQPSTLPPTSTVPETSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPDGDNLAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRKTEESNFKKDQETKTMAKTTTGTKRSLVKESSSATLRPEGSKKAKGSSSDEEIFTLQVRGRERYEILKKLNDSLELSDVVPASDAEKYRQKFMTKNKKENRESSEPKQGKKLMVKDEGRSDSD