wanglab/gogpt-training-data huggingface dataset:
Protein: Sucrose isomerase (D9MPF2)
Organism: Erwinia rhapontici (Pectobacterium rhapontici)
Interaction partners:
Sequence:
MDSQGLKTAVAIFLATTFSATSYQACSAGPDTAPSLTVQQSNALPTWWKQAVFYQVYPRSFKDTNGDGIGDLNGIIENLDYLKKLGIDAIWINPHYDSPNTDNGYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDIVINHTSDQHAWFVQSKSGKNNPYRDYYFWRDGKDGHAPNNYPSFFGGSAWEKDDKSGQYYLHYFAKQQPDLNWDNPKVRQDLYDMLRFWLDKGVSGLRFDTVATYSKIPNFPDLSQQQLKNFAEEYTKGPKIHDYVNEMNREVLSHYDIATAGEIFGVPLDKSIKFFDRRRNELNIAFTFDLIRLDRDADERWRRKDWTLSQFRKIVDKVDQTAGEYGWNAFFLDNHDNPRAVSHFGDDRPQWREHAAKALATLTLTQRATPFIYQGSELGMTNYPFKKIDDFDDVEVKGFWQDYVETGKVKAEEFLQNVRQTSRDNSRTPFQWDASKNAGFTSGTPWLKINPNYKEINSADQINNPNSVFNYYRKLINIRHDIPALTYGSYIDLDPDNNSVYAYTRTLGAEKYLVVINFKEEVMHYTLPGDLSINKVITENNSHTIVNKNDRQLRLEPWQSGIYKLNP
Protein: Keratin, type II cytoskeletal 8 (Cytokeratin endo A) (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) (Q10758)
Organism: Rattus norvegicus (Rat)
Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16128803}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16128803}. Nucleus matrix {ECO:0000269|PubMed:16128803}.
Interaction partners:
- Keratin, type I cytoskeletal 18
- Keratin, type I cytoskeletal 19
- Dystrophin
- Dystroglycan 1
- Uncharacterized protein
- Ubiquitin conjugating enzyme E2 V1 like 1
- Epithelial cell adhesion molecule
- Cadherin-1
- Utrophin
- Sequestosome-1
Sequence:
MSVRVTQKSYKMSTSGPRAFSSRSFTSGPGARISSSSFSRVGSSSSSFRGSLGGFGGAGVGGITAVTVNQSLLNPLKLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTSRSNMDNMFESYINNLRRQLEALGQEKLKLEVELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQIHEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVRAQYEEIANRSRAEAETMYQIKYEELQTLAGKHGDDLRRSKTEISEMNRNISRLQAEIDALKGQRATLEAAIADAEQRGELAVKDANAKLEDLKNALQKAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSSYGGLTSPGFSYGMSSFQPGFGSVGGSSTYSRTKAVVVKKIETRDGKLVSESSDIMSK
Protein: V-type proton ATPase subunit d2 (V-ATPase subunit d2) (Vacuolar H(+)-ATPase subunit d isoform 2) (Vacuolar proton pump subunit d2) (Q9LHA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
Subcellular location: Vacuole membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit F
- V-type proton ATPase subunit B2
- V-type proton ATPase subunit D
- V-type proton ATPase subunit H
- V-type proton ATPase subunit C
- V-type proton ATPase subunit B1
- V-type proton ATPase subunit a3
- Vacuolar ATP synthase catalytic subunit-related / V-ATPase-related / vacuolar proton pump-like protein
- V-type proton ATPase subunit a2
Sequence:
MYGFEALTFNIHGGYLEAIVRGHRAGLLTTADYNNLCQCENLDDIKMHLSATKYGPYLQNEPSPLHTTTIVEKCTLKLVDDYKHMLCQATEPMSTFLEYIRYGHMIDNVVLIVTGTLHERDVQELIEKCHPLGMFDSIATLAVAQNMRELYRLVLVDTPLAPYFSECLTSEDLDDMNIEIMRNTLYKAYLEDFYNFCQKLGGATAEIMSDLLAFEADRRAVNITINSIGTELTREDRKKLYSNFGLLYPYGHEELAICEDIDQVRGVMEKYPPYQAIFSKMSYGESQMLDKAFYEEEVRRLCLAFEQQFHYAVFFAYMRLREQEIRNLMWISECVAQNQKSRIHDSVVYMF
Protein: Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8 homolog) (Gy1) (Q9EQM6)
Organism: Mus musculus (Mouse)
Function: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WYQ5}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8WYQ5}. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies. {ECO:0000250|UniProtKB:Q8WYQ5}.
Interaction partners:
- Ribonuclease 3
- Endoribonuclease Dicer
- Probable ATP-dependent RNA helicase DDX17
- Heterogeneous nuclear ribonucleoproteins A2/B1
- N
- N
- Probable ATP-dependent RNA helicase DDX5
- Protein argonaute-2
- RISC-loading complex subunit TARBP2
- Protein argonaute-1
Sequence:
METYESPSPLPREPAGEAMMENRACPFQVLPHEQSPPPPLQTSSDAEVMDVGSGGDGQSEPPADDPFNFYGASLLSKGSFSKGRLLIDPNCSGHSPRTARHAPAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGVERSTRPECGQLLSPVSGDVHACPFGGSVGNGVGLGGESADKKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGTGGFTAKAIVQRDRVDEEALNFSYEDDFDNDVDALLEEGLCAPKKRRMEEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKDNEEREQNCDLAPSGEVSPVKPLGRSAELDFPLEEPDSMGGDSGSMDEKDPLGAEAAAGALGQVKAKVEVCKDESVDLEEFRNYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQYAKKNRPNLHILSKLQEEMKRLAAEREETRKKPKMSIVASAQPGGEPLCTVDV
Protein: Uncharacterized protein C12B10.15c (Q10448)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Ribonuclease H2 subunit B
- Ribonuclease H2 subunit A
Sequence:
MDSVKPIVKLEQAGSSNLEKASLLPCHISYDGPAPVFEYFHDKIQISNNTHSKTTVCLRGRELNGEELDLPENYTGQVVLCDDGLENDETSEKEIPESTWCINSTFEKVMLWNRDNMRSSEKDQWKRGVLEWIQFASKVKFNCSLYN
Protein: Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) (O00311)
Organism: Homo sapiens (Human)
Function: Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.
Subcellular location: Nucleus {ECO:0000305|PubMed:27401717}.
Interaction partners:
- DNA replication licensing factor MCM4
- Protein DBF4 homolog A
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM3
- Protein DBF4 homolog B
- Serine/threonine-protein kinase ATR
- Cell division control protein 45 homolog
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (A0QQC8)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Acts as a chaperone.
Interaction partners:
- Protein GrpE
- Chaperone protein ClpB
- Chaperone protein DnaJ
- Chaperone protein DnaJ
- Chaperonin GroEL 2
- Chaperonin GroEL 1
- Transcriptional regulator, MerR family protein
- Co-chaperonin GroES
- Heat-inducible transcription repressor HrcA
- ATP-dependent zinc metalloprotease FtsH
Sequence:
MARAVGIDLGTTNSVVAVLEGGDPVVVANSEGSRTTPSVVAFARNGEVLVGQPAKNQAVTNVDRTIRSVKRHVGTDWNIEIDDKKYTPQEISARVLMKLKRDAESYLGEDITDAVITVPAYFNDAQRQATKEAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQTILVFDLGGGTFDVSLLEIGDGVVEVRATSGDNHLGGDDWDDRIVTWLVDKFKGSSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRQPFQQVIKDAGISVSDIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIASHNKLLGSFELTGIPPAPRGVPQIEVTFDIDANGIVHVTAKDKGTGKENTIKIQEGSGLSKEEIDRMIKDAEAHAEEDRKRREEADVRNQAESLVYQTEKFVAEQRGAASDGGGSKVPEETLAKVDSAIADAKKALEGTDISAIKSAMEKLGVESQALGQAIYEATQAEQPAGGSDNGAPGDDNVVDAEVVDDDAGKENK
Protein: Cytochrome P450 71B23 (EC 1.14.-.-) (Q9LTM0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Carboxylesterase SOBER1
- Receptor-like protein 39
- PAMP-induced secreted peptide 2
- Class V chitinase
Sequence:
MSIFLCFLLLLLLLLVTIIFTRKSQSSKLKLPPGPPKLPIIGNLHYLNGLPHKCLLNLWKIHGPVMQLQLGYVPLVVISSNQAAEEVLKTHDLDCCSRPETIASKTISYNFKDIGFAPYGEEWRALRKLAVIELFSLKKFNSFRYIREEENDLLVKKLSEASEKQSPVNLKKALFTLSASIVCRLAFGQNLHESEFIDEDSMEDLASRSEKIQAKFAFSNFFPGGWILDKITGQSKSLNEIFADLDGFFNQVLDDHLKPGRKVLETPDVVDVMIDMMNKQSQDGSFKLTTDHIKGIISDIFLAGVNTSATTILWAMTELIRNPRVMKKVQDEVRTVLGEKRDRITEQDLNQLNYFKLVIKETFRLHPAAPLLLPREAMAKIKIQGYDIPEKTQIMVNVYAIGRDPDLWENPEEFKPERFVDSSVDYRGLNFELLPFGSGRRICPGMTMGIATVELGLLNLLYFFDWGLPEGRTVKDIDLEEEGAIIIGKKVSLELVPTRRQ
Protein: Sorting nexin lst-4 (Lateral signaling target protein 4) (Q8I4E2)
Organism: Caenorhabditis elegans
Function: Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21148288, ECO:0000269|PubMed:21494661, ECO:0000269|PubMed:22272187}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21148288, ECO:0000269|PubMed:21494661, ECO:0000269|PubMed:22272187}. Note=Recruited to phagosomal surface by phosphatidylinositol trisphosphate. BAR and PX domains are required for the phagosomal localization. {ECO:0000269|PubMed:21148288, ECO:0000269|PubMed:21494661, ECO:0000269|PubMed:22272187}.
Interaction partners:
- Dynamin
- PX domain-containing protein
- PX domain-containing protein
- Phosphatidylinositol 3-kinase piki-1
- Intersectin-1
- EHS-1
- NECAP PHear domain-containing protein
- Rho-GAP domain-containing protein
- AP-2 complex subunit mu
- UDENN FLCN/SMCR8-type domain-containing protein.
Sequence:
MAQVKAEYDFQSQPNTGELSISAGEVLTVIRENIDGGWIEGRNVRGSVGLFPESYVTPYQASRPPPVLPPPLPPTSSGPPAASSRPFDDWGGASEVAAPPSYGAQHHHQPTPSVPEVTRSSYPSQNDDFDDEWTDEDDEQEPTRPNVQSSIGSNSRRDLSRSHSEHGGPDRGSNKVNKNINRFSNFVKSGVEAYVIGESKTTSQISERHEVVMNNGIIQWKPIQQYYTCIVDKPKKESKLKGLKSFIAYSITSSLTNIQRQVSRRYKHFDWLHEQLSAKYVLIPIPPLPEKQVAGRYEEDLIDHRKHILQLWVNKICRHPVLSQSEVWLHFISCTDEKDWKNGKRRAEKDEYIGGAFLNCITVPHQPLDPNNVDMQVERFQRSVKTSEEAMRVMQERMNMFQKVFAGPVKQNWQKMGSAFKTLQQSFEIDETVASRRLTEALAYTASEYHEIGQVFDAHTKNDMEPVLENLYSYKGTVQNVPDIIQVHKQAVQKFRDSEGRLSSAEAEKMKQRIDAMSYTVIAEVQHQTAEKVEDMKSTMGTYLKKQAMFYQEVATKLTSLAARYD
Protein: HopF (Q88A90)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Interaction partners:
- Effector protein HopAB2
- ShcF
- Type III effector HopU1
- Type III effector HopAI1
Sequence:
MGNICGTSGSRHVYSPSHTQRITSAPSTSTHVGGDTLTSIHQLSHSQREQFLNMHDPMRVMGLDHDTELFRTTDSRYIKNDKLAGNPQSMASILMHEELRPNRFASHTGAQPHEARAYVPKRIKATDLGVPSLNVMTGSLARDGIRAYDHMSDNQVSVKMRLGDFLERGGKVYADASSVADDGETSQALIVTLPKGQKVPVERV
Protein: Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90) (P04216)
Organism: Homo sapiens (Human)
Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Integrin alpha-M
- Integrin beta-2
- Endoglin
- Syndecan-4
- 5'-nucleotidase
- Hematopoietic progenitor cell antigen CD34
- Receptor-type tyrosine-protein phosphatase C
- Rho GTPase-activating protein 35
- Rho GTPase-activating protein 5
- Ephrin type-A receptor 4
Sequence:
MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNVTVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMSL
Protein: Sestrin 1 (Sestrin-1 isoform X2) (U3JAG5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDVRDAAGRWDALSSRDASSRNAAMELIQQEVIKKIESIGPMPDPQCSSPPPTMDDSLSSDLNALLAHVLMLSKRCPYEDVREKCICLLQRVQDVGVRIPRPVGNGPSRFIPEKEILQVSKLDERTQSIFEDAFAVLGRLDNISLVMGFHPQYLESFLRTQHYLLQMDGPLSLHCRHYIGIMAAARHQCTYLVNLHVNDFLQVGGDPKWLNGLEEAPRKLQALGELNKILAHRPWLLTKEHIERLLKAEEHSWSLAELIHAVVLLTHYHSLASFTFGCGITPDIHTDGGHTFRPPSLSGYCVCDIANGNGAQEDMFGNQQVSESSGEVEVLMERMKQLQECRDEEEASQEEMATRFEREKTECMLVVTSEDEECVPSRDVSRHFEDPSYGYKDFSRRGEHVPTLRVQDYSWEDHGFSLVNRLYSDFGQLLDEKFQIAFNLTYNTMATHQGVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTMVCSPEKITKRMYESFWRQFRHSEKVHVNLLLMEARMQAELLYALRAITRYMT
Protein: TrwG protein (O50335)
Organism: Escherichia coli
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MSKKQPKPVKAEQLKSYYEESRGLERDLIGEFVKSRKTAWRVATASGLFGLLGMVCGIVGFSQPAPAPLVLRVDNATGAVDVVTTLREHESSYGEVVDTYWLNQYVLNREAYDYNTIQMNYDTTALLSAPAVQQDYYKLFDGSNARDRVLGNKARITVRVRSIQPNGRGQATVRFTTQQHNSNGTVERPQHQIATIGYTYIGAPMRSSDRLLNPLGFQVTSYRADPEILNN
Protein: Vacuolar fusion protein MON1 homolog (Q9SKN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in membrane trafficking through the secretory apparatus. In complex with CCZ1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
Subcellular location: Endosome {ECO:0000269|PubMed:24824487}. Prevacuolar compartment {ECO:0000269|PubMed:24824487}.
Interaction partners:
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar fusion protein CCZ1 homolog A
- Vacuolar fusion protein CCZ1 homolog B
- Ras-related protein RABG3b
- Ras-related protein RABG3f
- TIP41-like protein
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- AT4g33380/F17M5_140
- Ras-related protein RABG3c
- Aquaporin TIP4-1
Sequence:
MATSDSRSSPSSSDTEFADPNPSSDPETNSERVQSQLESMNLSQPSEVSDGSHTEFSGGGDDNDDEVASANGNEGGVSNGGLLREGVAGTSGGEVLLRAENPVEMEAGEEPPSPTSSGYDGERGSSGGATSTYKADDGSEDEIREANVDGDTASQHEAAWLPGKRHVDEDDASTSWRKRKKHFFILSNSGKPIYSRYGDEHKLAGFSATLQAIISFVENGGDRVNLVKAGNHQVVFLVKGPIYLVCISCTDETYEYLRGQLDLLYGQMILILTKSIDRCFEKNAKFDMTPLLGGTDAVFSSLVHSFSWNPATFLHAYTCLPLPYALRQATGTILQEVCASGVLFSLLMCRHKVVSLAGAQKASLHPDDLLLLSNFVMSSESFRTSESFSPICLPRYNAQAFLHAYVHFFDDDTYVILLTTRSDAFHHLKDCRVRLEAVLLKSNILSVVQRSIAEGGMRVEDVPIDRRRRSSTTNQEQDSPGPDISVGTGGPFGLWHFMYRSIYLDQYISSEFSPPVTSHRQQKSLYRAYQKLYASMHVKGLGPHKTQYRRDENYTLLCWVTPDFELYAAFDPLADKAMAIKICNQVCQRVKDVENEVFLQGASPFSW
Protein: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) (Q9HCC0)
Organism: Homo sapiens (Human)
Function: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11170888, ECO:0000269|PubMed:16023992}.
Interaction partners:
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- Propionyl-CoA carboxylase alpha chain, mitochondrial
- Isovaleryl-CoA dehydrogenase, mitochondrial
- Pyruvate carboxylase, mitochondrial
- Harmonin-binding protein USHBP1
- Enoyl-CoA hydratase, mitochondrial
- Methylglutaconyl-CoA hydratase, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- Peroxisomal bifunctional enzyme
- Negative elongation factor C/D
Sequence:
MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAKDGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAANVLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGIFRM
Protein: Innexin inx1 (Innexin-1) (Protein optic ganglion reduced) (Protein ogre) (P27716)
Organism: Drosophila melanogaster (Fruit fly)
Function: Structural component of the gap junctions. Essential for generation and/or maintenance of postembryonic neuroblasts and normal development of optic lobe.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction. Basolateral cell membrane. Note=Accumulates in the basolateral membrane of follicle cells in oocytes and epithelial cells in embryonic salivary gland and hindgut.
Interaction partners:
- Innexin inx3
Sequence:
MYKLLGSLKSYLKWQDIQTDNAVFRLHNSFTTVLLLTCSLIITATQYVGQPISCIVNGVPPHVVNTFCWIHSTFTMPDAFRRQVGREVAHPGVANDFGDEDAKKYYTYYQWVCFVLFFQAMACYTPKFLWNKFEGGLMRMIVMGLNITICTREEKEAKRDALLDYLIKHVKRHKLYAIRYWACEFLCCINIIVQMYLMNRFFDGEFLSYGTNIMKLSDVPQEQRVDPMVYVFPRVTKCTFHKYGPSGSLQKHDSLCILPLNIVNEKTYVFIWFWFWILLVLLIGLIVFRGCIIFMPKFRPRLLNASNRMIPMEICRSLSRKLDIGDWWLIYMLGRNLDPVIYKDVMSEFAKQVEPSKHDRAK
Protein: Probable spore germination protein GerPA (P62164)
Organism: Bacillus anthracis
Function: Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor (By similarity).
Interaction partners:
- Spore gernimation protein GerPB
- Spore gernimation protein GerPC
- Spore germination protein GerPE
- Spore gernimation protein GerPD
- YhcN/YlaJ family sporulation lipoprotein
- Probable spore germination protein GerPF
Sequence:
MPAMVGHIRIVNIGSSGIFHIGDVFAIRPISYSRAFAGAGSFNVGDNVSVYNYQSATTVNDSDVVDQAIIGST
Protein: Gtpbp5 protein (Mitochondrial ribosome associated GTPase 2) (I6L986)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVSTRLVLARTCTVFEGVLKWAPSTRAVLRPSHLLLQASCRLLSVGIVDHAKHREPSGKKVLSEKKLKRHFVDHRRVLVRGGSGGSGMSCFHSEPRKEFGGPDGGDGGNGGHIILRVDQQVKSLSSVLSQYQGFSGEDGGSKNCSGRGGATLYIQVPVGTLVKEGDKIVADLSNLGDEYVAALGGAGGKGNRFFLANDNRAPVTCTPGQPGQERVLYLELKTMAHAGMVCP
Protein: P2X purinoceptor (B1AUD7)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000681}.
Interaction partners:
Sequence:
MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLTILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDTDCHAGESVVAGHGLKTGRCLRVGNSTRGTCEIFAWCPVETKSMPTDPLLKDAEGFTIFIKNFIRFPKFNFSKANVLETGNKHFLKTCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIHIEWDCDLDKAASHCNPHYYFNRLDNKHTQSISSGYNFRFARYYRDPHGVEFRDLMKAYGIRFDVIVNGKGAFFCDLVLIYLIRKSEFYRDKKFEKV
Protein: Adenomatous polyposis coli homolog (Protein APC) (P70039)
Organism: Xenopus laevis (African clawed frog)
Function: Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator.
Interaction partners:
Sequence:
MAAASYDQLVKQVEALTMENTNLRQELEDNSNHLTKLETEATNMKEVLKQLQGSIEDEAMASSGPIDLLERFKDLNLDSSNIPAGKARPKMSMRSYGSREGSLSGHSGECSPVPVGSFQRRGLLNGSRESAGYMEELEKERLLLIAEHEKEEKEKRWYYAQLQNLTKRIDSLPLTENFSMQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRVQTRVGKIHQIEEEILRIRQLLQSQVAEAAERTPQSKHDAGSRDAEKLPDGQGTSEITASGNVGSGQGSSSRADHDTTSVMSSNSTYSVPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARASGSAALDNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLINDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKSCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALDVKKESTLKSVLSALWNLSAHCTENKADICSVDGALAFLVSTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNAKDQEGLWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSVPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTTHRNKQRHKQNLCSEYALDSSRHDDSICRSDNFSIGNLTVLSPYINTTVLPGSSSPRPTMDGSRPEKDRERTAGLGNYHSTTESSGNSSKRIGIQLSTTAQISKVMDEVSNIHLVQENRSSGSASEMHCMSDERNSQRKPSSNHPQSNPFTFTKAESSTRGCPVAFMKMEYKMASNDSLNSVSSTEGYGKRGQVKPSVESYSEDDESKFFSYGQYPAGLAHKIQSANHMDDNDTELDTPINYSLKYSDEQLNSGRQSPTQNERWSRPKHIIDSEMKQSEQRQPRTTKTTYSSYTENKEEKHKKFPPHFNQSENVPAYTRSRGANNQVDQSRVSSNLSNNSKASKPHCQVDDYDDDKTTNFSERYSEEEQQEDETERQNKYNIKAYASEEHHGEQPIDYSRKYSTDVPSSAQKPSFPYSNNSSKQKPKKEQVSSNSNTPTPSPNSNRQNQLHPNSAQSRPGLNRPKQIPNKPPSINQETIQTYCVEDTPICFSRGSSLSSLSSAEDEIEGRERNSRGQESNNTLQITEPKEISAVSKDGAVNETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSGSSLDSFESHSIASSIASSVASEHMISGIISPSDLPDSPGQTMPPSRSKTPPPPQTVQAKKDGSKPIVPDEERGKVAKTAVHSAIQRVQVLQEADTLLHFATESTPDGFSCASSLSALSLDEPYIQKDVQLKIMPPVLENDQGNKAEPEKEFIDNKAKKEDKRSEQEKDMLDDTDDDIDILEECIISAMPRKPSRKNKKVPQPTPGKPPPPVARKPSQLPVYKLLSSQNRLQTQKHVNFTHSDDMPRVYCVEGTPINFSTATSLSDLTIESPPSEPTNDQPNTDSLSTDLEKRDTIPTEGRSTDDTDASKPLNPTTVLDEDKAEEGDILAECIHSAMPKGKSHKPYRVKKIMDQINHTSAATSSGNSRSMQETDKNKPTSPVKPMPQSIGFKERLKKNTELKLNPNSENQYCDPRKPSSKKPSKVANEKIPNNEERTKGFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFEDDDIDLSKEKAELRKEKGTKDTDQKVKYKHENRAINPMGKQDQTGPKSLGGRDQPKALVQKPTSFSSAAKGTQDRGGATDEKMENFAIENTPVCFSRNSSLSSLSDIDQENNNKETEPLKQTGTSETQLGLRRPQTSGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKRKPSKIKNEVGKSRSNSVGGILAEEPDLTLDLRDIQSPDSENAFSPDSENFDWKAIQEGANSIVSRLHQAAAAGSLSRQGSSDSDSILSLKSGISLGSPFHLTLDKEEKTITSNKGPKILKPAEKSALENKKTEEEPKGIKGGKKVYKSLITGKSRSSSDFSSHCKQSVQTNMPSISRGRTMIHIPGVRASSPSTSPVSKKGPVFKNVPSKGSNENPSSSSSPKGTKPLKSELVYGSRPSSTPGGSSKGNSRSGSRDSASSRPSPQPLSRPLQSPGRNSISPGKNGISPPNKFSQLPRTTSPSTASTKSSGSGRMSYTSPGRQLSQPNLSKQSGLPKTHSSIPRSESASKSLNQNVNTGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSSSSRADSPPRSQTQTPALSPSLPDMALSTHSIQAGGWRKMPPNLNPAAEHGDSRRRHDISRSHSESPSRLPITRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKQQVCSFPGPRSECSSSAKGTWRKIKESEILETPSNGSSSTIAESNCSLESKTLVYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNSPPVIDNVLDQGQKEEAAKDCHTRHNSGNGNVPLLENRQKSFIKVDGLDTKGTDPKSLINNQQETNENTVAERTAFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSNGENSTSRPSQIPTPVTNSTKKRDSKTETTDSSGSQSPKRHSGSYLVTSV
Protein: Uncharacterized protein (Q4GZA1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRQLIPLKYCCVADSIYRVCFVSLCFSPSPNFHCSPLFPPFFLLLATKYRVRVCSRHGFHFWVVFNRRRTSIFDPQARSMLSYTVKEEVKDEKLPGANNFADVGGSLEDEEPMTLYTCANCTRVVALCPSSQLMCTHCVHRTGSSTVFYKVRQQPTTYDTI