wanglab/gogpt-training-data huggingface dataset:
Protein: TGFB induced factor homeobox 1 (F8VVS9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEME
Protein: (R,R)-butanediol dehydrogenase (EC 1.1.1.4) (Acetoin reductase/2,3-butanediol dehydrogenase) (AR/BDH) (O34788)
Organism: Bacillus subtilis (strain 168)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21856851}. Secreted {ECO:0000269|PubMed:21856851}. Note=Present in the cytoplasm early in growth, as cells become stationary protein also accumulates in the medium; secreted protein is not processed (PubMed:21856851). {ECO:0000269|PubMed:21856851}.
Interaction partners:
- Alpha-acetolactate decarboxylase
- HTH-type transcriptional regulator AlsR
- Acetolactate synthase
Sequence:
MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHGHQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYAVRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIKEKSQVKILVRPN
Protein: Ankyrin 2 (A0A5F9ZHG3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEDNNE
Protein: polynucleotide adenylyltransferase (EC 2.7.7.19) (Q9NIR7)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEWMYGPTKPLEVPRPQDHDYDESEMLYGVLAECPSISPNPVLTLVESMALRIVQRHSQNTQEQWARAYPFGSCGLSAAVAESDLDVALICPSVLTTDIFFDEFPRLLYNSVGPVSVVAARVPVVKFEYRGTAVDVVFVSVGLPQPPTEEQMLDDSFLLKVARETRPSANGIRFTFEIKRRLPVPYDVFTAVLKTVKLWAMRRMVYGNVYTYPNGAVLAIMVARVCQVLPSSHPSTLLRFFFLFYTQWMSRHDRISPVYLTATLEGRGRIPGLPDSWKPSKDKICCDLFPVISPAYPYVNDASSVGRCGLEALYSEITRVQCILTEARTLPLEEMWEPYRIEEEYSTFLVVGVSCAGHSMAETEQALSVWSSYVASRLRILIYSIERHAQARPCPRKIRLKKDNHVGGSSCFLSVNFLIGVKAKEGGPTPQPSLFTEACGEFHHAVKEGCNNDSIPWSFQRNDRAMHWPRVKFLEVHQVLHLLQDLK
Protein: Protein ARABIDILLO 1 (F-box only protein 5) (O22161)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes lateral root initiation and development, independently of auxin (IAA) and abscisis acid (ABA).
Subcellular location: Nucleus {ECO:0000269|PubMed:16434475}.
Interaction partners:
- Protein REDUCED CHLOROPLAST COVERAGE 1
- F-box protein SKIP28
- U-box domain-containing protein 27
- Probable serine/threonine protein kinase IREH1
- Importin subunit alpha-4
- Importin subunit alpha-1
- Armadillo repeat only 1
- GATA transcription factor 7
Sequence:
MSRRVRRKLEEEKGKDKVVVLPSYPETSISNEEDLVAPELLHGFVDWISLPYDTVLQLFTCLNYRDRASLASTCKTWRCLGASSCLWTSLDLRPHKFDASMAASLASRCVNLHYLRFRGVESADSLIHLKARNLIEVSGDYCKKITDATLSMIVARHEALESLQLGPDFCERITSDAIKAVAFCCPKLKKLRLSGIRDVTSEAIEALAKHCPQLNDLGFLDCLNIDEEALGKVVSVRYLSVAGTSNIKWSIASNNWDKLPKLTGLDVSRTDIGPTAVSRFLTSSQSLKVLCALNCHVLEEDESLISYNRFKGKVLLALFTNVFDGLASIFADNTKKPKDIFAYWRELMKTTKDKTINDFIHWIEWIISHTLLRTAECNPEGLDDFWLNEGAALLLNLMQSSQEDVQERSATGLATFVVVDDENASIDCGRAEAVMKDGGIRLLLELAKSWREGLQSEAAKAIANLSVNANIAKSVAEEGGIKILAGLAKSMNRLVAEEAAGGLWNLSVGEEHKNAIAQAGGVKALVDLIFRWPNGCDGVLERAAGALANLAADDKCSMEVAKAGGVHALVMLARNCKYEGVQEQAARALANLAAHGDSNNNNAAVGQEAGALEALVQLTKSPHEGVRQEAAGALWNLSFDDKNRESISVAGGVEALVALAQSCSNASTGLQERAAGALWGLSVSEANSVAIGREGGVPPLIALARSEAEDVHETAAGALWNLAFNPGNALRIVEEGGVPALVHLCSSSVSKMARFMAALALAYMFDGRMDEYALMIGTSSSESTSKNISLDGARNMALKHIEAFVLSFIDPHIFESPVVSSTPTMLAQVTERARIQEAGHLRCSGAEIGRFVTMLRNPDSTLKACAAFALLQFTIPGGRHAMHHVSLMQNGGESRFLRSAAASAKTPREAKIFTKILLRNLEHHQAESSI
Protein: Deoxyuridylate hydroxymethyltransferase (Deoxyuridylate hydroxymethylase) (EC 2.1.2.-) (Gp29) (dUMP hydroxymethylase) (dUMP-HMase) (P31654)
Organism: Bacillus phage SP01 (Bacteriophage SP01)
Function: Catalyzes formation of 5-hydroxymethyldeoxyuridylate (5HMdUMP) as a step in the pathway that replaces dTMP by thymidine hypermodifications in the viral genome. As a final result of the pathway of hypermodification, hydroxymethyluracil substitutes for a subset of thymidines in the viral DNA. These modifications probably prevent degradation of viral DNA by the host restriction-modification antiviral defense system.
Interaction partners:
Sequence:
MYTFSGSKPTQLYMDILSTVIKEGDVLAPRGKRIKEIRPVMIEFKNPIRRTTFLKGRNINPFFQVAESLWILAGRSDVGFLLDYNKNMGQFSDDGVFFNAPYGERLRFWNRSDANNFIYNPLDQLRDVYEKIKADPDTRQAVAVIYNPLFDNINNDTKDRPCNLLLSFKLRNGKLDLSVYNRSNDLHWGTFGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVYLDDYGAKITEDIQKVYGVNLETDEAPVVEDFEELLDPNPRMSYTMNELNQFLNEYFGIVDSLMRDDETYMHDGDCAQMLLNQIRHEPDEYIKVTLLLMVAKQALNRGMKDTVATAMNWIPLCEIKVSALRFLYKSYPEYINQYDLDEKLMKYIRREE
Protein: tRNA (mnm(5)s(2)U34)-methyltransferase, chloroplastic (EC 2.1.1.61) (5-aminomethyl-2-thiouridine methyltransferase) (MnmC-like methyltransferase) (atMnmM) (Q8GUP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MAAGFFQAEMSILSSTLARSYSLPIRKTLMTFDFRIAMQRNPCLRIRRSCVAAFSSTPSHSRNFPIRGLEDVFVGYLFGRKKATEVAHVVWEQVIQKGDTVIDATCGNGNDTLAMLKMVMHDSVGCGGYVYAMDIQKDAIESTSSLLDQAVGSKEKECVKLFNLCHSKMGEIVPENARVRMVAFNLGYLPGGNKSIITLSDTTLSALKAAERILKPGGLISLVVYIGHPGGREELEVVEAFGSGLPVSDWICCKFQMLNRPLAPVLVFMFKREN
Protein: Dual specificity protein phosphatase 1 (AtDsPTP1) (EC 3.1.3.16) (EC 3.1.3.48) (Q9ZR37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Dephosphorylates MPK4 in vitro.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein-tyrosine-phosphatase PTP1
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 6
- Mitogen-activated protein kinase 3
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
- acid phosphatase
- Inositol diphosphatase DSP4
- Probable protein phosphatase 2C 10
- Mitogen-activated protein kinase 4
- Metal ion-binding protein
Sequence:
MSSRDRGSPSSSSSSSSLPGIEKYNEKVKNQIQALVRVIKVARTYRDDNVPSLIEQGLYLGSVAAASNKNVLKSYNVTHILTVASSLRPAHPDDFVYKVVRVVDKEDTNLEMYFDECVDFIDEAKRQGGSVLVHCFVGKSRSVTIVVAYLMKKHGMTLAQALQHVKSKRPVASPNAGFIRQLQDLEKSMQVSDQFFSF
Protein: Vacuolar fusion protein MON1 (Autophagy-related protein 12) (Monensin sensitivity protein 1) (P53129)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking. The CCZ1-MON1 complex acts as a guanine nucleotide-exchange factor (GEF) for Rab-type GTPase YPT7, promoting nucleotide exchange on YPT7 and triggering endosomal maturation by activating YPT7 on late endosomes.
Subcellular location: Endosome, multivesicular body membrane {ECO:0000305|PubMed:12387888}; Peripheral membrane protein. Prevacuolar compartment membrane {ECO:0000269|PubMed:12364329}; Peripheral membrane protein. Vacuole membrane {ECO:0000269|PubMed:12364329, ECO:0000269|PubMed:14662743}; Peripheral membrane protein. Note=The association of the MON1-CCZ1 complex with the vacuole is regulated by the C-Vps/HOPS complex. {ECO:0000269|PubMed:14662743}.
Interaction partners:
- Vacuolar fusion protein CCZ1
- Ypt/Rab-type GTPase YPT7
- Vacuolar protein sorting-associated protein 41
- Vacuolar morphogenesis protein 6
- Syntaxin VAM3
- Ras-related protein SEC4
- Vacuolar morphogenesis protein 7
- E3 ubiquitin-protein ligase PEP5
- Vacuolar protein sorting-associated protein 21
- Vacuolar membrane protein PEP3
Sequence:
MNLNESYLDAEIPKGQLKHSKSGNFEGIPIVATTSEPTTSVNLDETFFKKAPIAMPICDDHSVSKSTSVNSLNTTSLASRRSPLQTKKLQAKNNLLSADLAKSNDDTTRALNSPKKDFGPYLDSENDIRSRLAESIYSMETSIRGSELQRRPYVSNEIPNVFKFSKFNSNCKLNESQTLCDKNFFIFTSAGKPIYCMHGKDEQIMSYTGLVNTVISYFQVNGPSELKTISTLTSGKRLTFLDKSPILLMAQSERGESSNELLNQLDFLYSYILSSLSERQLLRLFSKRENFDLRNYLESTDFENLDEICSLICNRMFPDLLLNSLQCLPFNHSSRLKLQNVVLQQLEKRQDIPRGTLLYGLIIAPQNKLCCVLRPRGHTLHTTDLHLLFCLISHQFQNLDETQELWVPICFPKFNSSGFLYCYIKFLPNDTHSNEKSALVLISAQKDAFFSLKSFSDELIIKLEEEKLLKKINTSKGFKLSDIPAPMVHHFIYKSKQNVQYVMPHFEVNSNIALDSSQGLEYELKLKTYYQQLHGTVVRDNGNLLSRSMLNFVRWSSKDNEDLAMDETQMDFSELDEYIIGNSSFKQESVNMVGMAWVTPTFELYLIGNNGIVDKRVLFKSARKVANWCQKHESRLFISDGAVF
Protein: KLTH0C07942p (C5DEB9)
Organism: Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Interaction partners:
- Autophagy-related protein 29
- Autophagy-related protein 17
- Autophagy-related protein 13
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 9
Sequence:
MSSEANPPVLEPFTVTVVDRNVKHQVEGEPEEEGHPDHEVQGVMFATNVKYIFEDDQELLPEQEDPAIENVVIIEADESLRVTQVELISDQFKQVGYEVRDGNEVCIDALSRFETPRQLGNLPLEKLVQLYKLQNDQLHSLFNTL
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (Q682I4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Complex I assembly factor TIMMDC1, mitochondrial
- Putative methyltransferase At1g22800, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13-B
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
- NADH dehydrogenase 1 alpha subcomplex subunit 8-A
- NADH dehydrogenase 1 alpha subcomplex subunit 8-B
- Probable complex I intermediate-associated protein 30
- NADH:ubiquinone oxidoreductase intermediate-associated protein 30
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
Sequence:
MAVRQKAMATLPKLIQSMRNEVTKQPSLVLPSLRRAFSLYDQINLIDNVPEDQLRFQEFDETSFTVNGVKYEGSLLCVGNLLMSWSPRYFSDITTDSLSIFQTVRPIPELLIVGCGRYNHPLNPQVRQFVKSIGMKLETVDSRNAASTYNILNEEGRIVAAALLPYGVTS
Protein: H+ coupled di/tri-peptide cotransporter 2 (A5A4L7)
Organism: Sus scrofa (Pig)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Membrane {ECO:0000256|RuleBase:RU003755}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003755}.
Interaction partners:
Sequence:
MNPFQKNESKETLFLPVSTEEVPPRPPSFPKKPSPKICGSNYPLSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWSEDTSTSVYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGHMIHTILSMVGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFVTPMLRGDVQCFGKDCYALAFGVPGMLMIIALVVFSMGSKIYKKPPPEGNIVTQVVRCIWFAISNRFKNRSGDIPKREHWLDWASEKYSKQLIMDVKALTRILFLYIPLPMFWALLDQQGSRWTLQATRMNGNLGFFVLQPDQMQVLNPFLVLIFIPLFDLVVYRLVAKCGINFTSLRKMAVGMILACLAFAVAAAVEIKINGMAPPQPDSQEGFLQVLNLANDEVKVTVLGNENSSLLEESIKSFQTMPHYSKLHLKTKREDFHFQLKYHNLSVYTEHSVEEKKLYTLIIREDGKSISSMMVKDAESRATNGMTAMRFVNTLHEEVNISLGTDTSFSVGKDYGVSAYRTVQRGEYPVVHCRTKDENFSLNLGLLDFGAAYLFVITNSTGQGPRVQKIEYTPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGLVQWAEFILFSCLLLVVCLIFSIMGYYYIPIKPEDIQGSADKQIPQIQGNMINLETKKTKL
Protein: Non-selective voltage-gated ion channel VDAC1 (Voltage-dependent anion-selective channel protein 1) (E1BYN7)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane raft {ECO:0000256|ARBA:ARBA00004314}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004314}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
Sequence:
MAVPPAYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANSETSKVSGSLETKYRWVEYGLMFTEKWNTDNTLGTEITLEDQLARGLKLTFDSSFSPNTGKKSAKIKTGYKREHINMGCDMDFDIAGPSIRGALVLGYEGWLAGYQMTFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNEKLETAVNLAWTAGNSNTRFGIAAKYQIDPDASFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFEA
Protein: Probable monoxygenase (P71662)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative cytochrome P450 132
- Uncharacterized HTH-type transcriptional regulator Rv1395
Sequence:
MMPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMRIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRISS
Protein: F-box/kelch-repeat protein At3g16580 (Q9LUS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAHEEKRPWEFSLSLPWELIEEILSRVPPESLLRFKTVSKQWNALFRDKTFINNHKMTFRFILATKSKIYSVSIDPKIVVRELTLDIPGLESHEIPKKLVDCDKLLLCDMEKGVVLWNPWLRHSTWIDQGSNHTRMESYGIGYNNKGSYKIFAFCDRKENHTQRLLTIHDSASDAWKDREPIDNSQGKQIVHNIYTKISGVSLNGNLYLVTYFETTDLVYHLIEINSSSESVVKFCDLPCGTSNFLKDAFVLRVFEGDRFSLLKQCHATKKIEIWVSKYKINNNLDRDVEWIKFMEVSSPNLPDLVDGFDSQPSYFIEDKRLVVCSCNETGRAWIYVFGENKLISKTQIDSVVDLWPSHWTFIPSLVPVPRAQREEPAELQV
Protein: Evolved beta-galactosidase subunit alpha (Beta-gal) (EC 3.2.1.23) (Lactase) (P06864)
Organism: Escherichia coli (strain K12)
Function: The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme.
Interaction partners:
- Evolved beta-galactosidase subunit beta
- Inner membrane transporter YgjI
- HTH-type transcriptional regulator EbgR
- Alpha-galactosidase
- Aldose 1-epimerase
- Beta-galactosidase
- Uncharacterized protein YihR
- Glucokinase
- Xylose isomerase
- Glucosidase YgjK
Sequence:
MNRWENIQLTHENRLAPRAYFFSYDSVAQARTFARETSSLFLPLSGQWNFHFFDHPLQVPEAFTSELMADWGHITVPAMWQMEGHGKLQYTDEGFPFPIDVPFVPSDNPTGAYQRIFTLSDGWQGKQTLIKFDGVETYFEVYVNGQYVGFSKGSRLTAEFDISAMVKTGDNLLCVRVMQWADSTYVEDQDMWWSAGIFRDVYLVGKHLTHINDFTVRTDFDEAYCDATLSCEVVLENLAASPVVTTLEYTLFDGERVVHSSAIDHLAIEKLTSASFAFTVEQPQQWSAESPYLYHLVMTLKDANGNVLEVVPQRVGFRDIKVRDGLFWINNRYVMLHGVNRHDNDHRKGRAVGMDRVEKDLQLMKQHNINSVRTAHYPNDPRFYELCDIYGLFVMAETDVESHGFANVGDISRITDDPQWEKVYVERIVRHIHAQKNHPSIIIWSLGNESGYGCNIRAMYHAAKALDDTRLVHYEEDRDAEVVDIISTMYTRVPLMNEFGEYPHPKPRIICEYAHAMGNGPGGLTEYQNVFYKHDCIQGHYVWEWCDHGIQAQDDHGNVWYKFGGDYGDYPNNYNFCLDGLIYSDQTPGPGLKEYKQVIAPVKIHARDLTRGELKVENKLWFTTLDDYTLHAEVRAEGETLATQQIKLRDVAPNSEAPLQITLPQLDAREAFLNITVTKDSRTRYSEAGHPIATYQFPLKENTAQPVPFAPNNARPLTLEDDRLSCTVRGYNFAITFSKMSGKPTSWQVNGESLLTREPKINFFKPMIDNHKQEYEGLWQPNHLQIMQEHLRDFAVEQSDGEVLIISRTVIAPPVFDFGMRCTYIWRIAADGQVNVALSGERYGDYPHIIPCIGFTMGINGEYDQVAYYGRGPGENYADSQQANIIDIWRSTVDAMFENYPFPQNNGNRQHVRWTALTNRHGNGLLVVPQRPINFSAWHYTQENIHAAQHCNELQRSDDITLNLDHQLLGLGSNSWGSEVLDSWRVWFRDFSYGFTLLPVSGGEATAQSLASYEFGAGFFSTNLHSENKQ
Protein: La-related protein 1 (dLarp) (Q9VAW5)
Organism: Drosophila melanogaster (Fruit fly)
Function: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:30772175}. Cytoplasm, cytosol {ECO:0000269|PubMed:10878606, ECO:0000269|PubMed:14668392, ECO:0000269|PubMed:17951964}.
Interaction partners:
- Polyadenylate-binding protein
- ATP-dependent RNA helicase DHX15 homolog
Sequence:
MSSKEETPSTGGAAPVATVAASGSATTSYANVVQNLETKKSGTSNTTTTTARATVDNKENQPNLKSFKSWSEEAAAAEAAGESPIVGSVSLAQTGEKRAAASGGDNTAENSSELDDNNDFVPVLSHHRRDRKKARKEKPRDQQPAGGRGDGQKPQQAGGRRVPGSSDTERKSVRPRAPRGGSPRKSAAGAAGAAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAGAAPPPKRFIAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQEQLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKEVKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAPPSAQCHAEKEELDFQFDEELMDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGRAPKHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWTTTNVVADYKTVNVISQADFEKLAGGRNKSVLPPQVVPPPPPFEEDLDETLVGDTTLNSTLNNTLKSRRARFYAAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGSSAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDETIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSLNPGRQLNRHRSVSESDGTAVIAAGGRRLNTTITNRSDYVGRLLQQQHQQQQQQQHHQYQQGYGGYNQQQNRRRTGSFGSTTVRIRSGSLGNKPQVANRNQGSQHELRRGGSNSGLAPHKRQQQQKPKPGAGSQTGSTRATTSAAATATTAASAATSTAATPAVTVSSGSSSSKK
Protein: SUN domain-containing protein 3 (Sad1/unc-84 domain-containing protein 1) (Q5SS91)
Organism: Mus musculus (Mouse)
Function: As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:20711465}. Nucleus inner membrane {ECO:0000305}. Note=Localized to spermatid nucleus posterior pole lateral regions excluding the implantation fossa during entire sperm head elongation. {ECO:0000269|PubMed:20711465}.
Interaction partners:
- Nesprin-3
- Nesprin-1
- Protein KASH5
- Nesprin-2
- Nesprin-4
- SUN domain-containing protein 1
- SUN domain-containing protein 2
- SUN domain-containing protein 5
- Sperm-associated antigen 4 protein
Sequence:
MLTRSWKIILSTVFISTFLLVGLLNHQWLKETEFPQKPRQLYTVIAEYGSRLYNYQARLRMPKEQQELLKKESQTLENNFREILFLIEQIDVLKALLKDMKDGVHNHSLPVHRDAVQDQATTDVLDEEMSNLVHYVLKKFRGDQIQLADYALKSAGASVIEAGTSESYKNNKAKLYWHGIGFLNYEMPPDMILQPDVHPGKCWAFPGSQGHILIKLARKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGVMKKCEGEEIFLGQFIYNKMEATIQTFELQNEASESLLCVKLQILSNWGHPKYTCLYRFRVHGIPSDYT
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 (Oligosaccharyl transferase subunit KCP2) (Keratinocyte-associated protein 2) (KCP-2) (Q5RL79)
Organism: Mus musculus (Mouse)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N6L1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N6L1}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Oligosaccharyltransferase complex subunit OSTC
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Sequence:
MVVGTGTSLALSSLLSLLLFAGMQIYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKITGKGKKRN