wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor ATOH7 (Atonal bHLH transcription factor 7) (Helix-loop-helix protein cATH-5) (cATH5) (Protein atonal homolog 5) (Protein atonal homolog 7) (O57598)
Organism: Gallus gallus (Chicken)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract. Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8N100}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5}.
Interaction partners:
- Visual system homeobox 2
- Visual system homeobox 1
- POU domain protein.
- Homeobox protein SIX3
- Paired box protein Pax-6
- POU domain, class 4, transcription factor 1
- Uncharacterized protein.
- Forkhead box N4
- Homeodomain transcription factor
- Cone-rod homeobox
Sequence:
MKTCQSSHLDSGVESDIQCRSGSGCVVKCSTERMESAAKRRLAANARERRRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERYSTEREWINLHCEHFHPESYHHYTGQKVATDSDPYAQRIFSYHPEHFQIAN
Protein: Uncharacterized protein YHR202W (P38887)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Vacuole {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized acyltransferase YDR018C
- Uncharacterized protein YHR127W
- Uncharacterized protein YGL081W
- Subtilisin-like protease 3
- Uncharacterized protein YBR138C
- Dihydroorotate dehydrogenase
- Purine nucleoside phosphorylase
- Probable guanine deaminase
- Uridine nucleosidase
- NAD-capped RNA hydrolase NPY1
Sequence:
MILKLVHCLVALTGLIFAKPYQQQQAVLAPSQDVPLRDIHIGDINFIHTTDTHGWLGSHLSQNDYDADWGDFVAFVDILREKILRQSRDVIVIDTGDKRDGNGLSDATWPPGLRSSEIFNMMDYDLLTLGNHELYTAESAILEYRGTSQSSKFKDKYVCSNVEFIEDDGTRVPFGNKYITFETPIMKQRVLALSFLFSFQRANNRAIVTPPLEEITQKSWFQNMVETNREEEIDLIIVFGHLPATDPTEREMHKIHALIRKYYPNTVIQYFGGHTHIRDFVQLDSKSTCLQSGRFAETVGFLSINMTDPVDAESPIFSRRYIDFNKEAFKYHLSKLGHDSNVPVSTKKGKTISRLVNDLRHELNLNEKLGYIPQTYYVSTRPLNSEENLYHLITHKILPNLIPPKNYEPSMSRFILINTGSVRYDLYKGPFTKDTEYIVMPFNNDWRFITVPLVVASRVETYLNKGPVIASLGIPSSSHHKQHFGGFQKCPFINNPNLSEGYTTEDDFGCHGDDTPHNSQREYDIPNVVQCKEVKKVQEEEADPSKMVHVIFYSFMELDILNAVNSIINDLGLRMENLTTNDCSHYGGDSTKKLLRDYFSQF
Protein: Uncharacterized RING finger protein C2A9.04c (Q9Y7K6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 4
- Ubiquitin-ribosomal protein eL40A fusion protein
Sequence:
MDSNTNENNSHASSNERQSSEGHDDYLNRNPNSEATEGEEGTHPTTGTQPVAFSIGTMFIITPQANFEGGENDPFANPFQPPVKRAVKEAWDSFEPLSNDQLMDLTCPICYDDMNENDEKQATKMPCGHIFGKNCLQKWLENHCTCPLCRKEVPHETVGSAHPPILFIIPHSHTLRGNQGNTAVSQENASNGVHSDFHPSEELNNANTDGRTGVDEPARQLHRIAFNRIRFILAPNRSATNTPVENTHPENPDSNTSTPTTRSEPLAGEGASIDAENASSRQETTPSDSRPSTLTSLFNAFFSSMPDRPSSNEPMTSNLTSNSGSMTNSTSTDLPTSNLPSQNAPARPVEPSPSIQPPNLLNLPTASPESTSWLPGSQTNIPANTNRSERPFTQLMTFHGLPSLADLPAVLESMFRPSGNNNLLNLNGIFHPDHNAQTENGQTLPENTDDTNSNATSAVPNLQNLNQQNAVTMGTNTPNNGSSPAVHPVIHIYLSRPPLQPAVSEQETPSEAVSREGTRSTDATMEDSSRPPSNGSFQGPGITHLSEMGQRILQRFQEEMENRMNQTRSESSTPAQQSAAGSSINVDTAGRQPSDEINIPGEYENSSEVAGSRNQTPTHSSIAVDTLSNVAVDQPAISTPSDVVGSDAGDTSKVSSGTSTPRMAAPIARRSNRHHPYSRPSSTRPQCQLEDQGICDPNDRFVHFECGHSVHERCQQSTSNSENQMDEEIGECPKCRNEEHK
Protein: ATP synthase subunit beta (EC 7.1.2.2) (Q8I0V2)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Interaction partners:
- ATP synthase subunit O, mitochondrial, putative
- ATP synthase subunit alpha
- ATP synthase subunit delta, mitochondrial, putative
- ATP synthase subunit gamma
- ATP synthase subunit C, putative
- ATP synthase subunit epsilon, mitochondrial, putative
- V-type proton ATPase proteolipid subunit
- Cytochrome c1, putative
- Reticulocyte-binding protein homolog 2b
- V-type proton ATPase 21 kDa proteolipid subunit, putative
Sequence:
MHKLKLFNHWKKLPMFMKFGGSPNLRMNCRYVSSSEHLNMKKNISVGNKNTEVSNKIKIGKIAQVIGAVVDVEFEDTPPSILNALEVELDNKKLILEVAQHLGNKVVRTIAMDATDGLVRGQEVKDSGNPICVPVGKETLGRIMNVIGEPIDECGHINHKKTLPIHRDPPLFTDQSTEPALLITGIKVVDLIAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKKHGGYSVFAGVGERTREGNDLYHEMITTGVIKKKKIGNNEFDFNGSKAALVYGQMNEPPGARARVALTGLTVAEYFRDEENQDVLLFIDNIYRFTQAGSEVSALLGRIPSAVGYQPTLATDLGALQERITTTKNGSITSVQAVYVPADDLTDPAPATTFSHLDATTVLSRSIAELGIYPAVDPLDSTSRMLTPDIVGAEQYQVARNVQQILQDYKSLQDIIAILGIDELSEQDKLTVARARKVQRFLSQPFAVAEVFTGKPGRFVELEDTIIGFSELLKGNCDDLPEMAFYMVGGLEEVKSKALEMAKQVS
Protein: Uncharacterized protein (Q38BC2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSHDGDDGSLQDVNPDLLELCKDPVAWREQRRRALREKVFGRGTGEDSGIAGSRVGNIDRSTAVSALDPLPNTPGPNGPTRKSAEDQEAYVLQQIMSHKRKREEATAIFGNTVAVEAPTVKTSVKEKLLLKLQKGK
Protein: Solute carrier family 41 member 1 (E7EXX2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (By similarity). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8IVJ1}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8IVJ1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Transient receptor potential cation channel, subfamily M, member 7.
- Transient receptor potential cation channel, subfamily M, member 6.
- Metal transporter
- Metal transporter
- Dephospho-CoA kinase domain-containing protein
- Solute carrier family 13
Sequence:
MVLWLKDQDKLSDMSTGTERIEMKKEGVPPAYHHSNGSVHPVILPDSPEEVPQTPGEYELTEVTSLPDCGDQENERPDMVVLDCRANAKGQREEDALLENASQSNESDDTSTDQSPVPPAPLKETSFSIGLQVLIPFLLAGFGTVAAGMVLDIVQHWTVFTEVTEVFILVPALLGLKGNLEMTLASRLSTAANIGQMDTAKDMWKMIMGNLALIQVQATVVGFLASIAAVIFGWIPEGNFRMGHAILLCASSVATAFIASLALGLIMIGVIIASRKVGINPDNVATPIAASLGDLITLSLLAGISTGLYKELEFNNYANPMVCAFFVALTPIWVLIARRIPSTREVLYSGWEPVIIAMAISSVGGLILDKTVSNPNFAGMAVFTPVINGVGGNLVAVQASRISTYLHMNALPIVEPNPAPRKCPTPWGTFFGSGVNSRSAKVLFLLVAPGHLVFLYTINSMRGGHTTLTYIFIAFYLAAALLQVIILLYLADWMVNWMWRRGMDPDNFSIPYLTALGDLLGTGFLALCFHILWLIGDRDTDVGD
Protein: Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) (P00949)
Organism: Oryctolagus cuniculus (Rabbit)
Function: This enzyme participates in both the breakdown and synthesis of glucose.
Subcellular location: [Isoform 1]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 2]: Sarcoplasmic reticulum {ECO:0000269|PubMed:1328221}. Note=Localizes to the junctional skeletal sarcoplasmic reticulum, probably by association with phospholipids and/or other proteins. {ECO:0000269|PubMed:1328221}.
Interaction partners:
- UTP--glucose-1-phosphate uridylyltransferase
- Alpha-1,4 glucan phosphorylase
- Glycogen phosphorylase, muscle form
- Alpha-1,4 glucan phosphorylase
- Phosphoglucomutase 2
- GDH/6PGL endoplasmic bifunctional protein
- Glucose-6-phosphate isomerase
- Phosphoglucomutase 2 like 1
- Glycogen debranching enzyme
- hexokinase
Sequence:
MVKIVTVKTKAYPDQKPGTSGLRKRVKVFQSSTNYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIVRIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAICPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRNIFDFNALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVANATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWHKFGRNFFTRYDYEEVEAEGATKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYHDPVDGSVSKNQGLRLIFADGSRIIFRLSGTGSAGATIRLYIDSYEKDNAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
Protein: Chaperonin CPN60-1, mitochondrial (HSP60-1) (P29185)
Organism: Zea mays (Maize)
Function: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
Subcellular location: Mitochondrion.
Interaction partners:
- Heat shock 70 kDa protein
- CLP protease regulatory subunit CLPX1 mitochondrial
- ATP-dependent Clp protease ATP-binding subunit clpX
- CLP protease regulatory subunit CLPX3 mitochondrial
- CLP protease regulatory subunit CLPX3 mitochondrial
- 20 kDa chaperonin, chloroplastic
- 20 kDa chaperonin, chloroplastic
- CCT-theta
- Putative TCP-1/cpn60 chaperonin family protein.
- Leucine aminopeptidase 2 chloroplastic
Sequence:
MYRAAASLASKARQAGNSLATRQVGSRLAWSRNYAAKDIKFGVEARALMLRGVEELADAVKVTMGPKGRNVVIEQSFGAPKVTKDGVTVAKSIEFKDRVKNVGASLVKQVANATNDTAGDGTTCATVLTKAIFTEGCKSVAAGMNAMDLRRGISMAVDAVVTNLKGMARMISTSEEIAQVGTISANGEREIGELIAKAMEKVGKEGVITIADGNTLYNELEVVEGMKLDRGYISPYFITNSKTQKCELEDPLILIHDKKVTNMHAVVKVLEMALKKQKPLLIVAEDVESEALGTLIINKLRAGIKVCAVKAPGFGENRKANLQDLAILTGGEVITEELGMNLENFEPHMLGTCKKVTVSKDDTVILDGAGDKKSIEERAEQIRSAIENSTSDYDKEKLQERLAKLSGGVAVLKIGGASEAEVGEKKDRVTDALNATKAAVEEGIVPGGGVALLYASKELDKLQTANFDQKIGVQIIQNALKTPVHTIASNAGVEGAVVVGKLLEQENTDLGYDAAKGEYVDMVKTGIIDPLKVIRTALVDAASVSSLMTTTESIIVEIPKEEAPAPAMGGGMGGMDY
Protein: ATP-dependent lipid A-core flippase (EC 7.5.2.6) (Lipid A export ATP-binding/permease protein MsbA) (P63359)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01703}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01703}.
Interaction partners:
- Tetraacyldisaccharide 4'-kinase
- Recombination protein
- 3-deoxy-manno-octulosonate cytidylyltransferase
Sequence:
MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGIALILNAASDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMILRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILVVLAPIVSIAIRVVSKRFRSISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGKRVIDRATGDLEFRNVTFTYPGREVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGHILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGIIVERGTHSELLAQHGVYAQLHKMQFGQ
Protein: Cation transporter HKT2;1 (OsHKT2;1) (Cation transporter HKT1) (OsHKT1) (Ni-OsHKT1) (Q0D9S3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Seems to be involved in regulation of potassium-sodium homeostasis. Functions as a high-affinity sodium transporter, which mediates increased sodium uptake in roots under potassium deficiency and contributes to sodium accumulation and salt toxicity. Involved in nutritional sodium uptake and distribution in potassium-starved roots to allow plant growth. Functions as sodium-potassium cotransporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17541409}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane. {ECO:0000269|PubMed:17541409}.
Interaction partners:
- Os04g0643100 protein
- Probable V-type proton ATPase subunit d
- V-type proton ATPase subunit F
- Vacuolar proton pump subunit B
- Vacuolar proton pump subunit B
- Na+/H+ antiporter
- Na+/H+ exchanger
- Delta-1-pyrroline-5-carboxylate synthase 1
Sequence:
MTSIYHDFIHNKLQSFGRIGRYFVNFVVLAHRFIALHIHPFWIQLSYFLLISILGSVLLMFLKPSNPEFRPGYIDMLFLSTSALTLSSLITIEMEVLSSSQIVVITLLMLLGGEVFVSFLGLMLRLNHKHNPEFSGDKVSSVPIELDTINSASTVISCEELQLEAAIPEVPSSTIKDLKRSKRLRWFLGFVVFSYFVVIHVAGFLLVLWYISRVSSAKAPLKKKGINIALFSFSVTVSSFANVGLVPTNENMAIFSKNPGLLLLFIGQILAGNTLYPLFLRLLIWFLGKVTKLRELKLMIKNPEELQYDYLLPKLPTAFLASTVIGLMASLVTLFGAVDWNSSVFDGLSSYQKIINALFMAVNARHSGENSIDCSLIAPAVLVLFIILMYLPPSTTFALSNGDEKTANKKAKRKLGLVVQNLAFSQLACISVFVIVAFITERSRLRNDPLNFSALNMIFEIISAYGNVGLSTGYSCSRLQKLHPGSICQDKPYSLSGWWSDEGKLLLVFVMLYGRLKAFTKGTGEYWRLW
Protein: Nanchung, isoform A (TRP channel protein nanchung) (Q9VUD5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGNTESNVTSGVKKQAGVSTQALYKFVNLKGGGLLVDMMKRACQTKQFAEIDHAIKTKVEPFLYNKGAGRYFPISKLVLLRNRDRPRTRQLPEIRALENPDDDFNIHDYCPEVSEAEYISNPTAYRFVCWDLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEECFRLVLARGADPDFQDTNGNTVLHMLVIYEKIEMFDVGYEVGTNIHIKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGDKLEHLELLDGVVIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYLLVALREARFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRRALVLRLNMTEEKEEMKEVQEMKRIHQRFAKKRQMEREARALRRQQEYEKFFGTAPKSECSDNNNF
Protein: Chromosome associated protein H2, isoform G (A0A0C4DHE3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MERILPEEAEAAYLSEAREQILEIAKNRPGTQVAKCIRAYDEQQDLASLVVLLEELSKNTDYSTDLRISLGYYIEELLRHCLGRNDVSRRSAIVAAGSALQYCGKIYGDRVEYLCQVVEHQIEALLTSELQKETPSGSAAPEKNERRPEETRKRHPKKLTNKEVDPYLLTLEPKRFKTMSDDKRFNAAGFVKCTRNRTIEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKMFTYHVEHRYNTLLPDIPFERLNLIKEYVHTNQVNTTEILNEHMTTKEYLDEYIALENQMLAARYGAIVTRRRRLVDSARFMEDNLDEGLAKKMCMDKNLPMDTNETVLIDQSLVDENSRSLTTAESTMGISQAENSTLKSSEVEATLSVSHIENSLSDSQEENPPLSSTLAINESSVLDSTRVDPIKDLTLDELLLIDSGISMEELSDIQMHTGQSFDDEGVVLSDLEDQRQLSPMLQMVSPSMEAKTLNIIEMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLPPEFDLFRQARLPIKREGQQKSPTTPRTVLQIGREAPQNEREPGSPCSLEFDEDLNFLGFRQRRPTFDSGFDIEEPRVSSCVSTIGEVKTELEDEIEANTNNLTDASASDALNENVNDTKESGLGDSLAQELNASTEPNAENNTANSSQLEVTATESSGTLSGLETTVDLGMESALVSSVLDLSTEPSAMDSNIINVTQPDNSDLEISTVQDQDTLHDEADANDLSAETPNPIADSAVDDCSLIRDWHRRLAPALEAAHERQNFNIKDLGTEILDICKAGNRTATLADVMADKDPSIMCRYMLASLVLTNHGNVSLDFENRDKSKPIDMSQFRMHLKSMKRMEINPEDDVGNINAAQSKSTPRSKQLNDSAHKPRTSTTASAPTKRKSAENSLSEVFAKTVRLIQPIPKMWPTPSDADSGISSMGSSLASTARLK
Protein: T-box transcription factor TBX3 (T-box protein 3) (O15119)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Transcription factor SOX-2
- POU domain, class 5, transcription factor 1
- Homeobox protein NANOG
- Krueppel-like factor 4
- Homeobox protein Nkx-2.5
- Probable RNA-binding protein 19
- Sal-like protein 4
- Steroid hormone receptor ERR2
Sequence:
MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSGLEAKPDRSRSASP
Protein: Cardiac hormone (Q9YGJ1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003686}.
Interaction partners:
- Atrial natriuretic peptide receptor 3-like
- Atrial natriuretic peptide receptor 3-like
- Atrial natriuretic peptide receptor 3-like
- Guanylate cyclase
- Guanylate cyclase
- Guanylate cyclase
- Guanylate cyclase
- Guanylate cyclase
- Guanylate cyclase
- Guanylate cyclase
Sequence:
MESRMVRTAVSWGLLLLLCQQTLVAAHVLGRPYPDSDLAQLKNLLERFEENLAAVATADDPAVDYEGPNPEPEHSKASPEWDRAPEAPQRPLLSDVRELAADESYSRAQSQRSRLQDLLMATRSKAMSGCFGARMDRIGTSSGLGCSPKRRS
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (Q582C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Polyubiquitin, putative
Sequence:
MHHGRKVLEAQKKRDTAPQQEYFPLSKEKVRHDRVHRAEEGKRDRENIGDMNLDDRREDNRGNCVSGRDASPGSSSRSKGVCSEYQYGEHKRQRLSPEGHDFKVSATQSSHGSTDAYLSSDRSIGNLRNKSRATDASMRNMVVGTSPLSTGKYNISMRNRATRSALADHDGEFTPKVNAPPAIGSSGQLPSQATDFHLPLKLYDTMKPSPRVGVGEKYPIKPSFQASHGSRDAYSHGPQLGMSDMAPAALKRSSAPSYGEVFSGAHVASLSRGRKMEGRNTPRSVRLGEWRTSHSRSGDGAVSEHAERRHRQANHPLQDHLFAPRRRALEIPPSDPFSFRGISSTESGSHSSSRTGNFTQHSEQHDGRVSSSYTQSPETGFEMWRGDKTPYNASQSGSPGCDAGYAPGSTNASSAVESHPSYLGSLSWAAPHVYQHQQEVPCIPRPHVEYSGFINPENDCYACSVLTLLLRSPLFCRALLASPTVECVRPVKSVNNTAATSSSSLTTSYDPTPAGVDHDTVREDPPPVSLHHVLKYFAGLLQCPQDIEGGIDMRPLRHFFRGNFFSGQQEDAHEFFLAVIDKLTEESKMFLKSTDASGGFDNPAVEEGEASKEISTDGQGTAAEGTPRSSGNESMPLWINTLITGQLLSIIRCGNAACGHEIATVDPFINLLVNIRKGEETNETLRQSNPNSSPCQESEHCAPNSEPVGSHGSLLYASPISPKPYYDVLSLLTYSFRFSALDSYVCDACGSSNQQLQGGCLLGALPPLLVVQMKRFATTYSPELGASVTKDVSPVLVNRNIVLYSLDEEHYNREEKTLRSSVLHAEQKAKQHSEGEAVDESATHVKATRCSYRLQGVVRHLGKSLYGGHYTTEFAQERVDRKEEEEEEEEEEGDGSTDGTKDGCGHQVDGERTGEGSVEREKHISSDQCAKRSWYMADDERVSALSEEYSMKEASRSCTCYLLLYEKVGEEAVSSHVWDILPRGSE
Protein: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) (Q14376)
Organism: Homo sapiens (Human)
Function: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Galactokinase
- UTP--glucose-1-phosphate uridylyltransferase
- N-acetylgalactosamine kinase
- Galactose mutarotase
- UDP-glucose 6-dehydrogenase
- UDP-glucose--hexose-1-phosphate uridylyltransferase
- Interleukin-11 receptor subunit alpha
- Beta-1,4-galactosyltransferase 1
- Galectin-10
Sequence:
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Protein: Aspartate aminotransferase (EC 2.6.1.1) (B9DG21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASLMLSLGSTSLLPREINKDKLKLGTSASNPFLKAKSFSRVTMTVAVKPSRFEGITMAPPDPILGVSEAFKADTNGMKLNLGVGAYRTEELQPYVLNVVKKAENLMLERGDNKEYLPIEGLAAFNKATAELLFGAGHPVIKEQRVATIQGLSGTGSLRLAAALIERYFPGAKVVISSPTWGNHKNIFNDAKVPWSEYRYYDPKTIGLDFEGMIADIKEAPEGSFILLHGCAHNPTGIDPTPEQWVKIADVIQEKNHIPFFDVAYQGFASGSLDEDAASVRLFAERGMEFFVAQSYSKNLGLYAERIGAINVVCSSADAATRVKSQLKRIARPMYSNPPVHGARIVANVVGDVTMFSEWKAEMEMMAGRIKTVRQELYDSLVSKDKSGKDWSFILKQIGMFSFTGLNKAQSDNMTDKWHVYMTKDGRISLAGLSLAKCEYLADAIIDSYHNALLYWETPIEL
Protein: Aldo-keto reductase yakc [NADP(+)] (EC 1.1.1.-) (Q09923)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Zinc-type alcohol dehydrogenase-like protein C16A3.02c
- Zinc-type alcohol dehydrogenase-like protein C2E1P3.01
- Putative S-
- Probable hydroxyacylglutathione hydrolase glo2
Sequence:
MSIPTRKIGNDTVPAIGFGCMGLHAMYGPSSEEANQAVLTHAADLGCTFWDSSDMYGFGANEECIGRWFKQTGRRKEIFLATKFGYEKNPETGELSLNNEPDYIEKALDLSLKRLGIDCIDLYYVHRFSGETPIEKIMGALKKCVEAGKIRYIGLSECSANTIRRAAAVYPVSAVQVEYSPFSLEIERPEIGVMKACRENNITIVCYAPLGRGFLTGAYKSPDDFPEGDFRRKAPRYQKENFYKNLELVTKIEKIATANNITPGQLSLAWLLAQGDDILPIPGTKRVKYLEENFGALKVKLSDATVKEIREACDNAEVIGARYPPGAGSKIFMDTPPMPK
Protein: LOC553223 protein (Q6DHB3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
HNLTRQRYRLWSTSSTMSDGRITSRPLQNEATGIDLHVPLYQEIRGSVITGHVEYQIVVVTCLSSFKSAIHKTGDVLQFVVSKKYSEIEQLYYSLKTKYPSIHLPPMPRKALFVSETDLCNRRVAFDELVKFLSKHPLLANCPELLEFLGAKTTAVEVKTINKPDFIEKEVDDGLDFFESGDPLQKPSEDVELLDPLGSEWLKKDVKPKDVCPVGKCVPKPKSETLFEEEDDTELFSPAKKGHVMLFDNTPLRSIDSSPFSNTSNGIKMTESKVDEDIEELLSVEMDLHKHLSVSKTVRCRPDTAMNPMKPKVKSKPVASERTSNLTQATDLQLSGTEVMNQMDILQYIQQNDLPASEDLDLFKS
Protein: Putative inositol monophosphatase 3 (IMP 3) (IMPase 3) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 3) (Myo-inositol monophosphatase A3) (Q9VYF2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- PAPS synthetase, isoform D
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- 3'
- Inositol-1-monophosphatase
- Inositol polyphosphate 1-phosphatase
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
- Palmitoyltransferase
- RE68347p
- FI09726p
- tRNA-dihydrouridine
Sequence:
MSEDKMNGRSIRINRLPATIVAILLTFVLVYFLNFHQEERPAIYGMLRSENPSRVNLRKMLIAAIQAAQRGGLEVLDVARSRQLKERSKGKTDEGVNDPFTDADGRSHCVMKQGLQRIFPRVQIFSEEDKEHCKQAHGYDLDPTVLHETAQIPDVTVNAQDVTVWVDPLDATKEFTEELYEYVTTMVCVAVAGRPIIGVIHSPFNGQTAWAWVGNSMSEYLSNLHPQHSPNNQAPIITVSRSHTAGAKDLARGIFGENVSLLTAAGAGYKVLQVVANNATAYLHTSKIKKWDICAGDAILHALGGTMTTLNDQLINYGPEESPVNTEGLLATLEQHDEYMDKLSKYREAHNGKLA