wanglab/gogpt-training-data huggingface dataset:
Protein: 4-aminobutyrate aminotransferase (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Q55FI1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Glutamate decarboxylase B
- Glutamate decarboxylase A
- Aldehyde dehydrogenase family 3 comG
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase
- Putative aldehyde dehydrogenase family 7 member A1 homolog
- Beta-ureidopropionase
- Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
- Pantoate--beta-alanine ligase
Sequence:
MSSSRLIKCLSSNNYIVRSFSKSSIPTTPTPDFPGEYKEPIVKTQIPGPQSKALIERLNKLQDPRAAHFFADYANSRGNYISDVDGNILLDLYCQIASIPIGYNNPELIKAAKSDRWVSAIINRPSLGVLPPKDWPALIENSFMQVSPKGLNQVFTAMCGSCANECAYKAVFMHYQHVKRGGKPFTPEELSSCMKNQEPGSPSLSILSFKKGFHGRTFGTLSTTRSKAIHKLDIPAFDWPAATFPDLKYPLAEHAKENREIEDRCLQEVEQLIKTWHIPVAGIIVEPIQAEGGDNYATPYFFQGLRDITKKHGVSMIVDEVQTGMGATGKFWAHEHWNLTSPPDIVTFSKKMQAAGFYHNLDYRPSESYRNFNTWMGDPVRALELEVVIGEIKKNHLLDNVVITGNYLKDGLFDIAARYPGLIQNIRGEGTFLAIDFPTPAERDRVISHIRLLGVEMGGCGERSIRFRPMLVCQPSHINQFLNRFDQTMKELYKN
Protein: Nucleolar protein 56 (Nucleolar protein 5A) (O00567)
Organism: Homo sapiens (Human)
Function: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9372940}. Cytoplasm {ECO:0000250|UniProtKB:Q9D6Z1}. Nucleus, nucleoplasm {ECO:0000305|PubMed:15574333}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 15 homolog
- H/ACA ribonucleoprotein complex subunit DKC1
- rRNA 2'-O-methyltransferase fibrillarin
- HEAT repeat-containing protein 1
- U3 small nucleolar RNA-associated protein 4 homolog
- WD repeat-containing protein 46
- KRR1 small subunit processome component homolog
- Nucleolar protein 58
- Transducin beta-like protein 3
- WD repeat-containing protein 36
Sequence:
MVLLHVLFEHAVGYALLALKEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVALENANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPEEAGHRSGSKKKRKFSKEEPVSSGPEEAVGKSSSKKKKKFHKASQED
Protein: Establishment of sister chromatid cohesion N-acetyltransferase 2 (E5RIE3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAEN
Protein: Histocompatibility 2, O region alpha locus (B2RST7)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MVLFVELVPVLLTVMSFLSPRGVRAIKADHMGSYGPAFYQSYDASGQFTHEFDGEQIFSVDLKNEEVVWRLPEFGDFAHSDFQSGLMSISMIKAHLDILVERSNRTRAVSVPPRVTVLPKTRVELGKPNVLICIVDDIFPPVINVTWLRNSQPITKGVAQTSFYSQPNHRFRKFHYLTFVPSAEDVYDCKVEHWGLDTPLLQHWEPQVLTPPPDTIETLICGLGLVLGLMGCLLGTVLMITGTRRPSIRR
Protein: Cilia- and flagella-associated protein 418 (P0DOC8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q3UJP5}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q3UJP5}.
Interaction partners:
Sequence:
MADDLDDLLDEVESKFCCNTSESKQTSRVMKHTDQKCDNLEERKLPRKQGRKRVENEIDIDAMLHEILDDDVDTPTSTHEPSPAKASSSAQTISKKCCPVFLGGSSVAHGIGTSVSERACNRLRCTYCDFSVITFDDHEWDSSCDYLFFRNNMPDYHKLKVHLRRRAGVRAYACQCSWISILTLSHLREQPQLKWVCGKHRA
Protein: FCS-Like Zinc finger 2 (Q8VZM9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Interaction partners:
- FCS-Like Zinc finger 16
- FCS-Like Zinc finger 11
- Protein MARD1
- MADS-box family protein
- Metalloendoproteinase 1-MMP
- Protoheme IX farnesyltransferase, mitochondrial
- Metalloendoproteinase 4-MMP
Sequence:
MEVSMRKPYFIEEEDDGFVSLSEMEAGVSSPSCYNYPQSYYYNHHHHQYSVSSPRSGKFHDFRFDNSYYGYGQPHFLDSCFLCKKRLGDNRDIFMYRGDTPFCSEECREEQIERDEAKEKKQSLSTSVKAMRRNEKRSSSSSPTRSRNYAFRTGTVAAA
Protein: Transforming growth factor beta receptor III (A0A0H3UK16)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MWLTAHIHPSAILLLTLSSLASAGPLSRSPCELLPVGVGHPVQAMLKSFTALSGCASRGTTSHPQEVHIINLRKGSAQGAREKTAEVALHLRPIQSLHVHQKPLVFILNSPQPILWKVRTEKLAPGVKRIFHVVEGSEVHFEVGNFSKSCEVKVETLPHGNEHLLNWAHHRYTAVTSFSELRMAHDIYIKVGEDPVFSETCKIDNKFLSLNYLASYIEPQPSTGCVLSGPDHEQEVHIIELQAPNSSSAFQVDVIVDLRPLDGDIPLHRDVVLLLKCEKSVNWVIKAHKVMGKLEIMTSDTVSLSEDTERLMQVSKTVKQKLPAGSQALIQWAEENGFNPVTSYTNTPVANHFNLRLREQVSDVGIMDEGMLPPFSILRNINPLPKPSARDAPPRNGFPFPFLPMDQDQSFPPLMPPHEDSVFLAGGPEEHQGSADVGFNVQCEKNKMVVSIEKETLQANGFGKPNITLQDSQCKATSNATHYILETPLSGCQTSKIPSHPSPVVLYINAIVISQSEQKDGSGWPVDDEDMEPGEVLLPGDALPELTERILPVNGHHATILFNCTYRKNQDSPFDTDAGSDDFLVDSTANVTFNMELYNNHFQFPNSQPFLTVTENRPVFVEIAATKADPNLGFMIQTCFISPDSNPAVQSEYVVIENICPKDDSVVYYPQRGDFPIPHAQMDKKRFSFTYRSKFNVSLLFLHCEMSLCSRRNDKEMNLAECMLPDEACTSLSIESILLIMMNTKTLTKPIVVISDDMPVTVKVPWDESPPRQGIIYVLDTPTVVGIAFAAFVIGALLTGALWFIYSHTGGTAAGQQVPSCPPVSENSSAAHSIGSTQSTPCSSSSNA
Protein: Minichromosome maintenance domain-containing protein 2 (MCM domain-containing protein 2) (E9Q956)
Organism: Mus musculus (Mouse)
Function: Plays an important role in meiotic recombination and associated DNA double-strand break repair.
Interaction partners:
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- DNA helicase MCM9
- DNA replication licensing factor MCM7
- DNA replication factor Cdt1
- WD repeat and HMG-box DNA-binding protein 1
- Cell division control protein 6 homolog
- Protein MCM10 homolog
- Cell division control protein 45 homolog
Sequence:
METLQMKEAALVYLDRSGGLQKFIDDCKSYNDSKQSYAVYRFSILIDPCDVVELDADLGNHILHHPLKAARVFQSVCFVAVKTLSLIGQLQTETQINIVLKLTHLPALPSYTLDLCEFPLNYASQRFYMMQGIVIAMTTITKYTQGARFLCSDGVCPLSKGFQYVRVHVPGATESATVRNDFLCSLCSSSLQEDRKFRVLGDKQIVEIITTKMFHAFQGDSKNQPFRFQSLGIFLRDELVNKMKIGNEYKIIGIPVCVKTSQTALCVEANNITPHTAKVPLGISDNFRRLLSLTSSSCWKFTAMLANVFASQIVAPGTYNLLKLCLLMSLVQTRDCNREREDCLDILVITSDTLLVDRLLNFSMNLVSRGIRHPVCTEVFPTVSRNKYGTGAVSIQAGSALLAKGGICFIGDLTSHKKDKLEQLQSALESRSVTVFIPGKKFGDDFDQQMTFPIQCSFWSFVDMDSSSRRNVQKTSTLIGQMDCSLIPANLAEAFGLLINCSEASPCHPLLPTVQHTLKKAVEPEGLLYLASKQFTTEDFEKLLAFAKSLNMEFSLEAERMIHGYYLASRRIRTDSIHGSKLSASALKYLVSLSEAHARLSLRTTVLREDALIAALLLEISLTLRYGATPFCVAPNALFPFELYNEEYLEQRDLYLTQCQQQLQQFIATCGPGTTVFSSDE
Protein: 2-oxoacid:ferredoxin oxidoreductase subunit alpha (OFOR) (EC 1.2.7.11) (A0A0E3JT70)
Organism: Saccharolobus solfataricus (Sulfolobus solfataricus)
Function: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Interaction partners:
Sequence:
MRISWMIGGAQGSGVDTSANIFGNAVAASGYYIYGNREYYSNIKGRHSYFNLTISDKPPRSIAQQIEILTSFDAETIFQHFNEVKDVLIYSTEVENTKAEQVQSMEPEITEHVVKFLKEKGYGTTVKDVINYLKKEKGVKVIPIDYMEILKKVADQAKVQLSVADRARNTIAIAASYKLLGLKEQYLINSITRTFRQEVFAKINTIAAQLAMQQIQPMYNLPELPNNEEKINLDGNTAAAIGKIYGGLRFQSYYPITPASDESVFIEAHQTVFTVDPKTGEKRKSTIVVVQAEDELAAINMASGAALTGVRAATATSGPGFSLMVEGMGWAGMNEVPVVITYYIRGGPSTGQPTRTSQADLMFALNAGHGEFPRIVIASGDHVEAFHDGTWALNLAQKYQTPVIHLVDKALANSYSIIPKKTLGMENIRIEKGKIVINTNTPELKRFEITEDGISPFAPLGTARVHYTGDEHDEYGFIAEASENREKMYEKRIKKLMTADKEIPEESRVNVYGNTDSKVAIITWGSPKGAILDAMEELENEGIKPMLIQIRMFSPFPKNLMRKLLNGKEFIIDVESNYFGQAGEVLKLNTGIEPTHYILKWNGRPMMRDEVKEGIKAVVQKGERRVVLHGGA
Protein: Gaegurin-LK2 (C3RT18)
Organism: Limnonectes kuhlii (Kuhl's Creek frog) (Rana kuhlii)
Function: Has antimicrobial activity against Gram-positive bacteria S.aureus ATCC 2592 (MIC=2.5 uM), S.aureus ATCC 43300 (MIC=2.5 uM) and B.subtilis (MIC=20.0 uM), against Gram-negative bacteria E.coli ML-35P (MIC=50.0 uM), P.aeruginosa PA01 (MIC=10.0 uM) and P.aeruginosa ATCC 27853 (MIC=5.0 uM) and against fungus C.albicans ATCC 2002 (MIC=5.0 uM).
Subcellular location: Secreted {ECO:0000255, ECO:0000269|PubMed:23054029}.
Interaction partners:
Sequence:
MFTMKKSLLLIFFLGTINLSLCEEERNAEEEKRDGDDEMDVEVQKRFLGPIIKMATGILPTAICKGLKKC
Protein: FGF1 intracellular binding protein (E9PSD3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSELDIFVGNTTLIDEDVYRLWLDVTDAVALRVRSGILEQTGATAAVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQALLIERYYAFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVDSQMDDMDMDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMEANFKNLSRGLVNVAAKLTHNKDYSLGPAVCGTLPLRPLATQRRAVLPESVFSVCPLPRWLPTPGPLGPLHGHPPRLPPAPVS
Protein: Prothoracicotropic hormone, isoform E (Q9VPR8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPWLPISIMAMALLSLTNKGIASQYASDEGLDEMVGLRSLEHRAEEQQPDRSTSKMLSALFGFSPSTPHPTEMAMVMPHQLPPMYYNDFYEDLVTTKRNDVHSAGCDCKVTNELVDLGGLHFPRFLMNAVCESGAGRDLAKCSHGSNCRPLEYKVKVLAQTSQSDHPYSWMNKDQPWQFKTVTVTAGCFCTK
Protein: Cytochrome P450, family 94, subfamily D, polypeptide 2 (Cytochrome P450-like protein) (Q9LXX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g08430
- ABC transporter D family member 1
- Mediator of RNA polymerase II transcription subunit 31
Sequence:
MEHFILISLLCFPIVIFFIFFPKNSSSEFGFKSYPIVGSLPGLVNNRHRFLDWTVETLSRCPTQTAIFRRPGKLQFVMTANPANVEYMLKTKFESFPKGERFISILEDFLGRGIFNSDGEMWWKQRKTASYEFSTKSLRDFVMSNVTVEINTRLVPVLAEAATNGKLIDLQDILERFAFDNICKLAFNVDSACLGDDGAAGVNFMQAFETAATIISQRFQSVISYSWKIKKKLNIGSERVLRESIMIVHKFADEIVRNRIEQGKVSDHKEDLLSRFISKEEMNSPEILRDIVISFILAGRDTTSSALSWFFWLLSMHPEVKDKILQELNSIRERTGKRIGEVYGFEDLKLMNYLHAAITESLRLYPPVPVDTMSCAEDNVLPDGTFIGKDWGISYNAYAMGRMESIWGKDCDRFDPERWIDETNGGFRGENPYKFPAFHAGPRMCLGKEMAYIQMKSIVAAVLERFVVEVPGKKERPEILMSVTLRIRGGLNVRVQERS
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q585I7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTLVQTLLERMLSAKGNTAQRQILIREEDIRTILNAVRDVFMSQPVVLDITPPVRICGDIHGQYYDLLRVFEKCGFPPYSNYLFLGDYVDRGRHSVETITLLFCYKIVYPENFFLLRGNHECASINKMYGFFDDVKRRYNAKLFKAFTDVFNTMPVCCVVGEKIICMHGGLSPDMTSLACVSEIERPLDVPDKGILCDLLWADPEEEVKGFLESDRGVSYLFGEDIVTDFLDMVDMDLVVRAHQVMERGYGFFANRQLVTIFSAPNYCGEFDNDAAVMNVDEKLQCSFAIIAAR
Protein: L71-8 protein (Q24059)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKLTLCFLVILGGVIVHGQSPDCKEIKDICSKCIQRLNDPYNKVDFINKGCRNRVRGSYVWKDQNLCELQAIPPNRAMNCVVIADVAKMRRVTPRPPG
Protein: Uncharacterized protein (Q38BS0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRRVRPLRAWNNRQHSDRERDRIARERQRHILYDNAGNVKLYGILFLLWEEFRVPIIAVATGFFVLLAYNKIVLYYSARQLAGERELDQKSESEARLSGKLKGDRYLIKPWRQVEDPDFLNIPSYAGKGVYSSKLFEDDVASTDPLFSERRRN
Protein: Periostin, osteoblast specific factor (A0JMK0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKKATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSITRVIEGGVRRRT
Protein: Growth hormone receptor type II (Q50H41)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MATSHILFICLVLILTVVSQEPPTSEQALPQIRPQITGCVSHDMNTFRCRWNVGTFQNLTEPGDLRMFYYINDTNISPKEWSECPNYMADRIDECFFNESYTKVWITYSVQLRSGDQDNLYDEVIFTVEDIVEPDPPIALNWTLLNVGLTGSHFDIMVSWEPPHSADVSMGWMTLQYEVQYREVNSTLWRMVNLEKGRQRSLYGLRTNTDHEVRVRCKTLASRNFGEFSDPIVIHIPTKESRFPVTVLLVFAALGLAVILILVIYSQQQKLMMILLPPIPGPKIKGIDPELFKKGKLAELTSILGDHPDLRPELYCEDPWVEFIELDMEEPNDRLTELDTQCLMDRTPSSDCPPLTIGFGDDDSGRASCCDPDLPEPEAFPLSNTSPSLEPSGASTEASSPVQTPTKGMTLWAVPGREDLYTQVSEVRPTGEVLLMPEEQSKVEKDAQEKAKEGKEKEKPRKEFQLLVVNADGGGYTTELDAGKMSAKLPTGRGSQPAPTEDSRLVQGQPFGEYQSLYFEAEMPPIPPASPVSSLLPLSVYTMVEGVDRQNSLLLKPSPPPAPQPVLTKLPLPTPTPEGYLTPDLLGNVTP
Protein: Aspartyl-phosphate phosphatase Spo0E (EC 3.1.3.-) (Stage 0 sporulation protein E) (Stage 0 sporulation regulatory protein Spo0E) (P05043)
Organism: Bacillus subtilis (strain 168)
Function: Aspartyl-phosphate phosphatase which specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation.
Interaction partners:
- Stage 0 sporulation protein A
- Sporulation initiation phosphotransferase F
- Sporulation initiation phosphotransferase B
- Aspartyl-phosphate phosphatase YnzD
- Aspartyl-phosphate phosphatase YisI
- Response regulator aspartate phosphatase B
- Sporulation kinase E
- 5-oxoprolinase subunit B
- Transition state regulatory protein AbrB
- RNA polymerase sigma-H factor
Sequence:
MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDCLINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK
Protein: Arrestin, beta 2a (Beta-arrestin-2 isoform X1) (A0A286YBG8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGDKAGTRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYIFTFQAYPPIPEESKPHSRLQERLLKKLGQNAYPFHFSIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSMEEKNHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQIEADDQVASSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKDVSNKEVLGVLVSYRVKVKLVVSRGGLLSSLLERDVSVELPFVLMHPKPSESSLSHSTSAVPMLDPPIDTNLIEFDTNSLIPDDDIVFEDFARLRLKGVIDKEEDC
Protein: Uncharacterized protein (A0A178WEI8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMTNSDSDHCTPAKTSISGDGLEKESDFKKQLNSEIDPQASSSQNDAITMEDGAVSVNNRDLQEIKESSFSKGSEQYRVDGALEESLNFEEKEQESEAQRLLEAEKRRLLAEIELGSIFRKSVDVDTLPKIEETMDNDVDKIELVDHTALVDVVHHPKRPGTAQNEKDTPRKLKKIGDKRNVIEGSGVENNGKQFRRLYTRKQLESMRFAHIVNQKNLWSEMYSRILPEVVTEYESLVYVKNYKSSKSNRVRGRTESGNEENLGTEEGTEDPEDYTDDNDDYNSILRPAFEVDGEPDFSTGPPEDGLEYLRRVRWEAKGIPNVRVAKIDESTYIKKEQSVYMPLIPEIPKCPEYLLPMKEWEDSLLLDFVHLRQTLTQSANSCEDEIISSQCVEDLLVEMFNKHLHTEEDESFGEVVTDIQGMDSVTRVSKLKKRICLVEKESGLQSSDCKWVVALCASLETPLDADTCACLRGLLRKCASVRAETSLEVGDEEVITMANMLITIAGRYFGQMGQ
Protein: LP11802p (Q8IGZ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRGLVEDTKRTKLSSANNNNLSSTSGSGRIKSSSLATGSSASGSSSKPLRSAVKTPTSGSATSLSSGTMAAKKAPQTGQQQVGKSAKSATAATPTGTTATAIGATATTRAQAAAAKSQKGQNPPSQQVQPKQQPPQPQQTQQQPLVLQQQQASNSSNTIALPKASHANTSEELAGGVQDTIYLCNFRVSVDGEWLCLKELQDIDVAGGTGNQAAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSKRFSGLSTGSGSGGNAGGGGGLDITDNGIMAIENLIGRRLCDMVNSGSSALGQSQSAK
Protein: E2F transcription factor 6 isoform 1 (E2F transcription factor 6, isoform CRA_c) (A0A0S2Z3K8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU003796}.
Interaction partners:
Sequence:
MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN
Protein: Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D) (Q3U2K5)
Organism: Mus musculus (Mouse)
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Interaction partners:
- Histone-lysine N-methyltransferase SUV39H1
- Histone H3.1
- Histone H3.2
- Lysine-specific demethylase 6B demethylase 6B)
Sequence:
MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQSYDNISNILIATPLQQVVSGQAGVFTQYHKKKKGMTVGEYRELANSKKYQTPPHLDFEDLERKYWKNRLYESPIYGADVSGSLFDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGRRLERLARELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRILQPERYELWKRGQDQAVVDHTETMVSTSQELTTRRVTKAPRKTWGLKRLRLRQVSRSLLPIATVSNVPCNMQVCHTSRQPSDVKGDDVQKSDSARASPHPLSLPSSGHMSTRRCSLGRRPCELGAQESSNGAPVKRQLPAGRDDTSPSPELQPQAVSGDLIVDSGLVNPGPQHLMTASEGGLTSDP
Protein: UDP-glucuronosyltransferase 1A1 (UGT1A1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-1) (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (UDP-glucuronosyltransferase 1A isoform 1) (P22309)
Organism: Homo sapiens (Human)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17179145, ECO:0000269|PubMed:17187418}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17187418}.
Interaction partners:
- UDP-glucuronosyltransferase 1A3
- UDP-glucuronosyltransferase 1A9
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1A8
- UDP-glucuronosyltransferase 1A10
- UDP-glucuronosyltransferase 1A7
- Cytochrome P450 3A4)
- UDP-glucuronosyltransferase 1A4
- Cytochrome P450 1A1
- UDP-galactose translocator
Sequence:
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A1B0GW84)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLPSSCEYLTLGKVARFRSAYVHGSPYAINMPIDIKPQRRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
Protein: F-box only protein 32 (Q7ZTY2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPFLGQDWRSPGQSWVKTEDGWKKTTKDDNETNNNVLERKSYCKEEHDKENLILSINYDVAAKKRKKDLPNNNTKIPYFYKDKWIYVHKGSTKERHGYCTLGEAFNRLDFCSAIKDTRRFNYVVRLLELIAKSQLPSLSGVAQKNYMNILERVVQKVLDDQQNVRPIKELLQTLYASLCSLVQDMGKSVLVGNINIWVHRMENILQWQQQLDNIQINRPKNTGMTLLELPVSLQLNIMQRLSDGRDLVSLGQVCPDLSMLTEDRLLWKKLCQYHFTDRQIRKRLMVSDKGQLEWKKMYFKLCRCYPHKEQYSDTLQFCTHCHILFWKDTDHPCTANNPESCCKAVSPQGFINLFKF
Protein: RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) (Q96PM5)
Organism: Homo sapiens (Human)
Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19483087}. Nucleus speckle {ECO:0000269|PubMed:14701804}. Cytoplasm {ECO:0000269|PubMed:15781263, ECO:0000269|PubMed:18006823}.
Interaction partners:
- Cellular tumor antigen p53
- RAB6-interacting golgin
- DNA polymerase eta
- Ubiquitin-conjugating enzyme E2 D2
- Androgen receptor
- E3 ubiquitin-protein ligase Mdm2
- N-terminal kinase-like protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Histone acetyltransferase KAT5
Sequence:
MAATAREDGASGQERGQRGCEHYDRGCLLKAPCCDKLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQHAQQTCEECSTLFGEYYCDICHLFDKDKKQYHCENCGICRIGPKEDFFHCLKCNLCLAMNLQGRHKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEGYRCPLCMHSALDMTRYWRQLDDEVAQTPMPSEYQNMTVDILCNDCNGRSTVQFHILGMKCKICESYNTAQAGGRRISLDQQ