wanglab/gogpt-training-data huggingface dataset:
Protein: Chloride intracellular channel protein 5 (Glutaredoxin-like oxidoreductase CLIC5) (EC 1.8.-.-) (Q8BXK9)
Organism: Mus musculus (Mouse)
Function: Required for normal hearing (By similarity). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:Q9NZA1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29425878}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9NZA1}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9NZA1}. Membrane {ECO:0000250|UniProtKB:Q9NZA1}; Single-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:17021174}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O00299}. Mitochondrion {ECO:0000250|UniProtKB:Q9EPT8}. Cell projection, stereocilium {ECO:0000269|PubMed:17021174, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:37952086}. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome (By similarity). Associates with the cortical actin cytoskeleton (By similarity). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (PubMed:17021174). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (By similarity). May localize to the centrosome in lens epithelial cells (PubMed:29425878). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q9NZA1, ECO:0000269|PubMed:17021174, ECO:0000269|PubMed:29425878}.
Interaction partners:
- Taperin
- Radixin
- Ezrin
- Glutaredoxin domain-containing cysteine-rich protein 2
- Unconventional myosin-VIIa
- Rho family-interacting cell polarization regulator 2
- Moesin
- Xin actin-binding repeat-containing protein 2
- Plastin-1
- Glutaredoxin domain-containing cysteine-rich protein 1
Sequence:
MTDSATTNGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNSPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVARRLSRS
Protein: Protein PHOX4 (F4JTI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylate clamp-type tetratricopeptide repeat protein that may act as a potential Hsp90/Hsp70 co-chaperone. Contributes to polar growth of root hairs.
Interaction partners:
- Syntaxin-22
- Arabidiol synthase
- CBS domain-containing protein CBSCBSPB2
- Expressed protein
- Protein NBR1 homolog
- Protein NLP9
- PB1 domain-containing protein tyrosine kinase
Sequence:
MGKPTAKKKNPETPKDASGGGGGGGGKSGKTYHRSTSRVFDEDMEIFISRALELKEEGNKLFQKRDHEGAMLSFDKALKLLPKDHIDVAYLRTSMASCYMQMGLGEYPNAISECNLALEASPRYSKALVRRSRCYEALNKLDYAFRDARIVLNMEPGNVSANEIFDRVKKVLVDKGIDVDEMEKDFVDVQPVCAARLKKIVKERLRKSKKKKKSGGKDEELKSPKVVVVDKGDEAEGRNKPKEEKSDKSDIDGKIGGKREEKKTSFKSDKGQKKKSGGNKAGEERKVEDKVVVMDKEVIASEIVDGGGSKKEGATVTRTIKLVHGDDIRWAQLPLDSTVRLVRDVIRDRFPALRGFLIKYRDTEGDLVTITTTDELRLAASTHDKLGSLRLYIAEVNPDQEPTYDGMSNTESTDKVSKRLSSLADNGSVGEYVGSDKASGCFENWIFQFAQLFKNHVGFDSDSYVDLHDLGMKLYTEAMEDAVTGEDAQELFQIAADKFQEMGALALLNWGNVHMSKARKQVCIPEDASREAIIEAVEAAFVWTQNEYNKAAEKYEEAIKVKPDFYEALLALGQEQFEHAKLCWYHALKSKVDLESEASQEVLKLYNKAEDSMERGMQIWEEMEECRLNGISKLDKHKNMLRKLELDELFSEASEEETVEQTANMSSQINLLWGSLLYERSIVEYKLGLPTWDECLEVAVEKFELAGASATDIAVMVKNHCSSESALEGMGFKIDEIVQAWNEMYDAKRWQMGVPSFRLEPMFRRRAPKLHDILENVFSGPV
Protein: DNA replication licensing factor MCM7 (EC 3.6.4.12) (Q1PS21)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365012}.
Interaction partners:
Sequence:
MALKDYAIEKEKVKKFLQEFYYDDELGKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYLRLFADVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFQGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHRVVKMTKSEDDVSGAGELSAEELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCRERQPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV
Protein: Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (A0A1B0GV75)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
Sequence:
MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWAELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGEAGVGSMPLGLVLSAWARALTDTCLLCGIWQQPKGSSCLSSTWTLHTGR
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A0A0R4ITJ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Catenin, beta 2.
- Catenin beta-1
- Phosphoinositide phospholipase C.
Sequence:
MLRNKAFHAAVWAACGILSTMVVDATECSIEIVKVISSTESIRLTLDNANVKCQYTVSVKDRHTDSKGCRQDREHSKCQIESLDPGTWYHLDVISTLDEKQQSQRAVTLQTRPSAVENLQVSGDANSLDVSWQPGKGKTERYWIVLIDSSGRDSAWNSTVASTATSYTMKGLISGRLYNITVVTEVGELQNSASTQAQTAPASVSKLRTENNGDRNSIRVLWDKASGDVDSYLVSLTTPGSNSIEKVLPPDDTYVVFENLSPGKGYQVSVSTRSGALSNKTWITGKADPGKVSDLVIENLSVRGALKISWTPPSGEWEHIRVALSNGSEVLRNQTVGRTAKEILLSGLNLLPGRVYRMAVSVENGGLANTVIYEGEIGLPPVSQLHVRHSDETSLSALWAHAASSSSRDGYIIQLFQSNTSTVIQTRNLSRDMRECTFNVLTPGRLYDITVTTTAKIIRSSATLQGRTQPLKVNHLKLSNKGSTDSLNASWEKPLGDLDFYHMLLLRDQQTVHNITASANTTSRLLPFLRPGALHKILVTTISGSQTSKLAEAECRTVPAAVSDITVTNSGPDFLNVSWKAAEGDVDNYVVMLKDQEKIVHTLATSKATTECVFRSLVSGRLYSISIATHSGSYRNQTLLQERTKPSTVQNPTAIHSARDDFLKLYWNHASGDYDYYVVTIEHNGTRLQSQKLNRTQSDCAFSDLVPGRLYNLTVSTWSGQHYSAVSIYGRTFPGAVGNLSLTERGGTFLRVSWTSAPGDVDHYELQILFNDTQVSAAVNLSSAIGEHLFSALTPGRLYKIVLSTHSGSYQRAEILEGRTVPSQVQSVHLSAGTADGSLRVSWSSADGDLDFYSVSLFQETHLQDSRRVPKHITQAEFYNLIPGQLYSVTVQSVSGSQTNNSTTTGRTEPSTVTGLRADNELSTHSLLVSWNPAVGVHDGYRLWLLDDGGTNIHNASVPAASRHHLFENLTPGRRYQAHVRTLSGTAESKDVVAEGQTRPSAVSALHVCSNTSSDLSFCWASAVGWVDGYELYLYDRDETLHYHTTLGSDALGWSFTLLQPGTHYKMTITSKSGKLSNQSSVWAHTAPASVPELHVENQGQTDSLLLSWTPAPGGLTGYSVTVDGREQRVGPEVTQVVFHSLVAGRLYLATVQTWSEDLSNSTTAVGRTVPAAPSSVSVSCSGGSVDMKWHVPDTGDYEDFEVTWFPQDTLYISHLRPTQRILEGLHPGRLYNISLRTVSGKRHSPVTYSRPVYHTIRTPPLPAPSIHCFPLSSTSVSCSWTPPHSDYDGFVVQCHRQGSGKAVYTHTLGNHTLSQQFDRLEPFKNYTIYVAVMSGDKQSSTVKNSVITMIDRPPVPPVTVRVNEHSAVITHFTIRFKFNCSWFSDANGAIRYFTIIATESNDVDNGLPEQRHPLPSYLDYRQNHSIKAYQTGYFHSTCAEGSDGKVQVFEINLGAGMKHLGGACKLDPESIQHGSHLCDGPLRSRTSYRLSVRAFTQLFDEENREFPHPLYTDTYLSLPLLTQSAPRSGLTGGITAALFLITMVLALTALLIYRKRAHKIAVQESPVMKMCKWKALPTSQMCLRIRSPVQAANFESHLAKLQSDSSYLLSEEFEGLKDVGRIQTQNAARLLGNRNKNRYNNILPYDSTRVRLSCLEDDPCSDYINANYIPGNNFRWEYIATQGPLPGTKDDFWRMVWEQNVHSLVMVTQCVERGMVKCDHYWPTDSEPLCYGDIVVQLLSEKVFPEWTIRDFKISCESQLRYPRMVRQFHYTIWPDHGVPDTTQSLIQFVRTVRDFINRTNSPGISVVHCSAGVGRTGTFIVLDRALQQLDRNCTVDIYGCVFDLRLHRSYMVQTECQYAYIHQCVRDVLRARKLGCERDNPLFPIYNNII
Protein: G-protein coupled receptors family 1 profile domain-containing protein (A0A060YPY0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ig-like domain-containing protein
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Endothelin-3
- Neuropeptide Y
- Endothelin-1
- Endothelin-1
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MDITSTIFAAPNSSEDTNSTSAPRPLPHSQSAAVFIVLMVTVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKCMITVVWVISAVISFPPLLMPKHDEHECLLNNETWYILSSCLVSFFAPGLIMILVYCKIYRVAKQRASTVGKFEVESPSSASLGGHPRKGELDDIDLEETCAPDSKPKKCHFSKRGKSCRAPSASKRNAQLSQDQRTRQMSLSKTKLAQMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAICRDSCPIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRRSFKKIICQTSHT
Protein: Uncharacterized protein C1105.13c (Q9Y816)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MITEFIKSFLLFFFLPFFLSMPMIFATLGEFTDDQTHHYSTLPSCDLLLIRGEVKENARCFLHNPKISHQHHSFWSLIEGCLEALQFGLLAILQGLFSQFAWEACSCTFACMLLTSERTEPSYPFSEITEVSRGGLHFVKLN
Protein: COG4 transport protein middle alpha-helical bundle domain-containing protein (D6XJQ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 5
- Syntaxin 5
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 7
Sequence:
MEQYQSQSHPQQQSQQVWNSLDDRVEFLLRRVAKLTEQRQHIAQDIARSVIADGGSLSSSIEEIKAVSYGLLPQFADRGAGLARHIAISASLAESSSRRVKQLDFLLSRVRAARMVADSLQEMRRSVIAVQTMIDRDELESAVQLIRKYEEASGKLGGRSVSARILLREEEGEDEHGEEVVSGVEEEEEEEEEVQPAVKLSSDEQMEERKETVSAVTVGETLQTQGIGDEGGVLASTSSTAGGHETAAEPRVKAAAKMRRKGTWKKGSSGCDEYGGRAAHNDNDVTANRGEVDDEVDRIIVNARQTVREKLMKRFYSAKVVNDKQTIMDTVRLLTLLGFRDECCCMYCSWMCEHTIVALNKMVERELRKIDDPNEAGMSHLALVSAGLDLVVATFENEEEFVLETFGDAGLLLLLTELHSRSTSQCVPVLKDFLKKRQEVLQAVDCTNNSPSPRGESNDNSGRSAVTSPRQPRALQSRGTTLDPRRTDQILEEMSHLVSCYHLYWTFAQSKQQECTQRVREKEGGAREQNDGMNQSADSLWSSRDNPLMTAVQEILAIFVPLQTHYFEAAFHQVLQIQLDAINASSHEHPMPSTTAAVTAGNNSTKQQVGYGSTTSNKAAATLMTGLAAAIYNSTTSGSSANTGGNDASGMVGALVNSSVSGAGNNSGIAVIDEDFLSSTSSQQLAPITLPDDVFYFLRISLHRAVNTKSTQIISAVFIACGELVQSQLIPTLNRYTALPHTTQLQKLQTVHQQRAQQQQGHNYLYTVPTRILRWTAATQCTITYIRRFADELRQLSRSQFSGKDVLRFSEQADDMDGTARELSTGIQQKLEDYAERCYQAHLARHIEPFATLSYEMTEDVFYQYELSDPWVQAFIAAADAALAHFDTYLDPRSFDLLLLALVKRVVSVARSLLLRKSISAYGALQVDREVRTFRTFFTGRAHEEQLREPFIQLMDMTALLLLDHPREAEQKQDQKAFQGGGFIYGGNELTPDEKRRVLRCRVEFKQEDIDRLRL
Protein: DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) (P97386)
Organism: Mus musculus (Mouse)
Function: The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
Subcellular location: Nucleus.
Interaction partners:
- DNA repair protein XRCC1
- DNA polymerase beta
- X-ray repair cross-complementing protein 6
- Bifunctional polynucleotide phosphatase/kinase
- X-ray repair cross-complementing protein 5
- Poly [ADP-ribose] polymerase 2
- Flap endonuclease 1
- Poly [ADP-ribose] polymerase 1
- DNA repair protein XRCC4
- Tyrosyl-DNA phosphodiesterase 1
Sequence:
MTLAFKILFPRNLCALGRKELCLFPEQNRWAAISQFSQWSETNLLGGCCLLQRRKPVLALQRGHLRPRATHLTFWPGSHVGLCTGPCAMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQISQHIADLSSKAAATPKKKAAVQAKLTTTGQVTSPVKGASFITSTNPRKFSGFSAAKPNNSEQAPSSPAPGTSLSASKCDPKHKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGGFSDGFHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELVMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCKGPPSKSSASAKTTEQKLNSPSSRGGIKPIPKHSPMKPGEKLAVKSSPVKVGMKRKATDETPCLKKVLLDVFTGVRLYLPPSTPDFKRLKRYFVAFDGDLVQEFDMGSATHVLGNREKNTDAQLVSSEWIWACIRKRRLIAPC
Protein: Collagen alpha-1(I) chain (Alpha-1 type I collagen) (P02453)
Organism: Bos taurus (Bovine)
Function: Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Interaction partners:
- Collagen alpha-2
- Collagen type III alpha 1 chain
- Integrin beta-1
- Collagen alpha-1
- Integrin alpha-2
- Collagen type V alpha 2 chain.
- SPARC
- Collagen alpha-2
- Lumican
- Collagen alpha-3
Sequence:
MFSFVDLRLLLLLAATALLTHGQEEGQEEGQEEDIPPVTCVQNGLRYHDRDVWKPVPCQICVCDNGNVLCDDVICDELKDCPNAKVPTDECCPVCPEGQESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEGGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPSGPPGPKGNSGEPGAPGSKGDTGAKGEPGPTGIQGPPGPAGEEGKRGARGEPGPAGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGAPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGAPGKDGVRGLTGPIGPPGPAGAPGDKGEAGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGPKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGSKGPRGETGPAGRPGEVGPPGPPGPAGEKGAPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPIGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNGLPGPIGPPGPRGRTGDAGPAGPPGPPGPPGPPGPPSGGYDLSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKEKRHVWYGESMTGGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTYDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGFDVGPACFL
Protein: Villin-2 (O81644)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ca(2+)-regulated actin-binding protein. Involved in actin filaments bundling. Caps the barbed end of actin filaments and is able to sever them in a calcium-dependent manner. Required for the construction of actin collars in pollen tubes. Acts redundantly with VLN5 (AC Q9LVC6) to generate thick actin filament bundles and to regulate polarized pollen tube growth. Acts redundantly with VLN3 (AC O81645) to regulate directional organ growth and in sclerenchyma development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10631247, ECO:0000269|PubMed:23715472}. Note=Present in the apical and subapical regions of pollen tubes.
Interaction partners:
- T-complex protein 1 subunit zeta 2
- AT3g56990/F24I3_70
- Conserved oligomeric Golgi complex subunit 6
- Beta-adaptin-like protein C
- Conserved oligomeric Golgi complex subunit 4
Sequence:
MSTKVLDPAFQGAGQKPGTEIWRIENFEAVPVPKSEHGKFYMGDTYIVLQTTQNKGGAYLFDIHFWIGKDTSQDEAGTAAVKTVELDAVLGGRAVQHREIQGHESDKFLSYFKPCIIPLEGGVASGFKTVEEEVFETRLYTCKGKRAIRLKQVPFARSSLNHDDVFILDTEEKIYQFNGANSNIQERAKALEVVQYLKDKYHEGTCDVAIVDDGKLDTESDSGAFWVLFGGFAPIGRKVANDDDIVPESTPPKLYCITDGKMEPIDGDLSKSMLENTKCYLLDCGAEIYIWVGRVTQVDERKAASQSAEEFLASENRPKATHVTRVIQGYESHSFKSNFDSWPSGSATPGNEEGRGKVAALLKQQGVGLKGIAKSAPVNEDIPPLLESGGKLEVWYVNGKVKTPLPKEDIGKLYSGDCYLVLYTYHSGERKDEYFLSCWFGKKSIPEDQDTAIRLANTMSNSLKGRPVQGRIYEGKEPPQFVALFQPMVVLKGGLSSGYKSSMGESESTDETYTPESIALVQVSGTGVHNNKAVQVETVATSLNSYECFLLQSGTSMFLWHGNQSTHEQLELATKVAEFLKPGITLKHAKEGTESSTFWFALGGKQNFTSKKASSETIRDPHLFSFAFNRGKFQVEEIYNFAQDDLLTEDIYFLDTHAEVFVWVGQCVEPKEKQTVFEIGQKYIDLAGSLEGLHPKVPIYKINEGNEPCFFTTYFSWDATKAIVQGNSFQKKASLLFGTHHVVEDKSNGGNQGLRQRAEALAALNSAFNSSSNRPAYSSQDRLNESHDGPRQRAEALAALSSAFNSSSSSTKSPPPPRPVGTSQASQRAAAVAALSQVLVAENKKSPDTSPTRRSTSSNPADDIPLTEAKDEEEASEVAGLEAKEEEEVSPAADETEAKQETEEQGDSEIQPSGATFTYEQLRAKSENPVTGIDFKRREAYLSEEEFQSVFGIEKEAFNNLPRWKQDLLKKKFDLF
Protein: Cold-inducible RNA-binding protein (Glycine-rich RNA-binding protein CIRP) (K7EPM4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYG
Protein: Small ribosomal subunit protein mS47 (3-hydroxyisobutyryl-CoA hydrolase, mitochondrial) (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) (P28817)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS47 has enzymatic activity in vitro, and is able to catalyze the specific hydrolysis of 3-hydroxyisobutyryl-CoA (HIBYL-CoA). However, because the turnover rate of mS47/EHD3 is only a fraction of that of the homologous mammalian enzyme, the physiological function of this activity remains unclear. Has an indirect role in endocytic membrane trafficking.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein mS43
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS10m
Sequence:
MLRNTLKCAQLSSKYGFKTTTRTFMTTQPQLNVTDAPPVLFTVQDTARVITLNRPKKLNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIFNFNKEFAKSIKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATENTKWAMPEMDIGFFPDVGSTFALPRIVTLANSNSQMALYLCLTGEVVTGADAYMLGLASHYVSSENLDALQKRLGEISPPFNNDPQSAYFFGMVNESIDEFVSPLPKDYVFKYSNEKLNVIEACFNLSKNGTIEDIMNNLRQYEGSAEGKAFAQEIKTKLLTKSPSSLQIALRLVQENSRDHIESAIKRDLYTAANMCMNQDSLVEFSEATKHKLIDKQRVPYPWTKKEQLFVSQLTSITSPKPSLPMSLLRNTSNVTWTQYPYHSKYQLPTEQEIAAYIEKRTNDDTGAKVTEREVLNHFANVIPSRRGKLGIQSLCKIVCERKCEEVNDGLRWK
Protein: Lethal giant larvae homologue 2 domain-containing protein (A0A0K3ATN9)
Organism: Caenorhabditis elegans
Interaction partners:
- Syntaxin-1A homolog
- Synaptosomal-associated protein
- Putative complexin-1
- Putative syntaxin-2
- Synaptobrevin-1
- t-SNARE protein aex-4
- Soluble NSF attachment protein 29
- Protein kinase C-like 3
- Acetylcholine regulator unc-18
- Phorbol ester/diacylglycerol-binding protein unc-13
Sequence:
MDRAKKKFASAIDGLRSLHNRTEINVDEKIQSEHCRFTRVVRHGLPEDPRCFAYDPVQRLIAIGTGRGHIRIIGDAGVDYLLKHESGEPVLHMQFLVNEGGLITSCGTDSIHLWNYRQKTAEIVHTVQLSKESVSCIHLPVAGKWLFIGTDKGNVYFLCLNSFLLSPYVINWNKAIDLSCRVHPGPVRQLAVSPAENTKLLIVYDKGIVVQWNLGTREVDRYPLDPPIKSVNWHFDGRQILTGNVDGSISLYNHKKSTEAIQRTTPHGSGPCRPIQQVEWKHMSETESIIMFSGGMPTDDGLPMPALTILKGGKSATVLEMDWPIIQFIPLNQNIWNSIPQCPHSVAVLLKHDFMVLDLNQNGHPVIESPHAMNIHESPVTCMAYYSDCPLDLIGALTLVGTKQRNKEFSARSWPVTGGLGRECATGHQELVVTGHKDGSLKFWQETGEHLQILYKLKSSSHFERLEEMETSDKVSHAVKYIELCLESRQLLVAGISGQVTLFRFTKQEICGTIAVVNIPLLGNLSSNLPNNDFDKSPVPNGPGKEIRRQRKIVSRESTNSLDTSDSGDERIVPFKVRGAPVKRPPGFVPELACFVPWHSHAKVDQITTICLNSSYGIIAIGTSSGLALVDTTQCALIYSWTTNELYGSDPTPAIQLSMQLSDAASPLEIDEFENDDTLIYNTDTGNYTLRSTRNSLTPSSNGFLHPGEMPTRPKSAANSSNKSGGMMGLFRRNTAELAATIRERYQGNRSESATTDRPDVEHRGETPPPTPNEGNKVQKAGRSHSVKGSFIRRFAKSSSSKEKKEVKIEVDNQSNSGIERSRSFHSHISEEGDSQRESPSSGRQLNTSSPSTSSQSLERSMSTQPQESITSLSFIHSYSKKNDSKMSPCLWVGTSAGASLALNLILPEDRFTSTIVVAPSVRGRKHCYYGTVVRLKGQVISQSFMDNTFCIISPASESYKEAAKEQSATSPDRSLLNRVNTKASLAPQYSSSIDSNDEISQILIVAAENEVKVVALPTFSQLYVQKFDEIPLVKATPTHIRGYPCLMCLSAAGQIIMLSLPSLRILQTSTIFPHSVEIDDPLCQKTAFSDHGLGVYMASQTEMEKYTMCSEIAEQTGESLGELFVPCEMPEQPKNNSFLKGVSSIFGGTPRNDPNDIDAILSENMGVKNSSGVNPMRSVARTIPGPSVQMDRAQAGGVSAGQAAAMALQNLNERTEKLNATVDATENLKNNAMSLSSRTGKLVEKYEKKKWYNF
Protein: N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) (Q3SZM5)
Organism: Bos taurus (Bovine)
Function: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- N-acetylneuraminate-9-phosphate synthase
- N-acylneuraminate-9-phosphatase
- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
- E3 ubiquitin-protein ligase RNF10
Sequence:
MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHMAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGVFQSIWVSTDHDEIENVAKQFGAQVHRRSSEASKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWGEIQKGVREMTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLFVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVNVPDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKKVGLSGVPADACAAAQKAVGYICKSSGGRGALREFAEHIFLLMEKVINSCQK
Protein: Histone superfamily protein (F4K162)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- TATA-binding protein-associated factor BTAF1
- TATA-box-binding protein 2
- TATA-box-binding protein 1
- Protein Dr1 homolog
- AT5g08190/T22D6_130
- Protein MIZU-KUSSEI 1
- At5g23100
Sequence:
MKKKLQTRFPATRIKKIMQTDEEVGKIAMAVPLLVSKALELFLQDLCNHTYDVTLSRGAKTVNAFHLKQCVQATNVFDFLRDTVAKVPDLGGSDTEDQSATKRRKVVDGSSCNDEDMIKTTQMHEVKHTSCGRGRRGRGRGRSSGRTGSGLSLKFEEDLEDGSPESSRTPSPENGSLSHDDTSWKKVASHNNHHSSNSEVKVRNFDLNVELDENGDNATWLETQLERSPDYPLEINEMKIDPDDQQQASASDEEDYDEESIDQE
Protein: Schlafen 4 (B2RWZ6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGNTPQLEKDVNPQTSIEPSVQVKCPGDILQGGRHAKRGRWMASWKGFHLGRRDSDCKMNITVDQDTDYAELVLSVGEITLGEKTRDSMKDSQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNPLPGILHLPHDYLDFMQYNDYFFVFVKPWKPNQRGPGIATWKTNLYKRIFSFSVELKAADAVQFLKSRPSSHGKTVCNETLNECLSLFNRDWLAYEETFCFTKSTHAEVKWTPKEKISPKEKILELLPQTVSAFANTDGGYLFIGLDGKTQQIIGFEAEKSDLVLLESEIEKCIQQLPVTHFCEEKEKIKYTCKFIEVHKSGAVCAYVCAIRVEKFCCAVFAAEPESWHVEGSCVKRFTTEEWVKRQMDATAVMPGKVICSPEALCMKPFSQHEGYEQLVRTELGSLRKGTLVVSKSWALDLGLQEKQEVIWDVLHISQGSLLTLHVFVQGDENLEGNSSLLGKLGAELKGYYKQIALTLKQTLVNHCGYTAKIGIIVKITYLGHKTMCLYDSSAKICYPQIYYLTTKAVKDLEKALAEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVYFSRNVLTHIRI