wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) (Phosphatase V) (PP-V) (Q27884)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in controlling cellularization or in regulating transcription of the genes involved in this process.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8223492}.
Interaction partners:
- LD07294p
- Fiery mountain, isoform D
- Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
- Protein phosphatase PP2A 55 kDa regulatory subunit
- Serine/threonine-protein phosphatase 2A activator
- Serine/threonine-protein phosphatase 2A activator
- Serine/threonine-protein phosphatase 2A activator
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
Sequence:
MGDVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVPDAERVIPKQNTTPYFL
Protein: Succinate-semialdehyde dehydrogenase [NADP(+)] 1 (SSADH 1) (SSDH 1) (EC 1.2.1.79) (P9WNX9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium. NAD(+) can substitute for NADP(+), but enzymatic activity is three times reduced.
Interaction partners:
- 4-aminobutyrate aminotransferase
- Succinate dehydrogenase flavoprotein subunit
- Probable succinate dehydrogenase [iron-sulfur subunit]
- Putative succinate-semialdehyde dehydrogenase [NADP
- Probable succinate dehydrogenase [iron-sulfur subunit]
- succinate dehydrogenase
- Succinate dehydrogenase 2 membrane subunit SdhC
- Probable succinate dehydrogenase SdhD
- 2-methylcitrate synthase
- Citrate synthase 1
Sequence:
MPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTVWIA
Protein: Expressed sequence AW551984 (D3Z518)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVRSGGLLTSIRDPVALKSIAVTLSINDFVAGVSATLNYENEEKSPLEAFFVFPMDEDSAVYSFEAFVDGKKIVAELQDKYQAHKRYEEALSGGYQAYLLEEDKCSRDVFCCNVGNLQPGSKVSLTLRYVQELPLEDDGALRYVLPAILNPRYHLSDGREDSNLDMKTPIVPLEELPYTLSMVATISSQLGISTIQSNCPLNPIEYTGDN
Protein: Cyclic nucleotide-binding domain-containing protein (Q7Z205)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Cyclic nucleotide-binding domain-containing protein
- Cyclic nucleotide-gated channel
- Guanine nucleotide-binding protein alpha-17 subunit
- Receptor-type guanylate cyclase gcy-10
- Receptor-type guanylate cyclase daf-11
- Ion transport domain-containing protein
Sequence:
MSTHSAQKLPNLHERKRRMSKKPDDDDLIPQHFEYENQYEKWRAANPRIEYDFSVDESGYIYWIWTFFVVCGCLYNIIVLSVLAFENIRYAYIEKILPINIAFDTVFLFDIILRSMLSFYEDGVLITSFSETWRHYVHSFYFAIDLLAIFPFDYLLIRKTSAAFCRLNRFLKIYRIANFIAQSYGKLTQVTISLSKIFTACFLLFHVNACVFYIISVNSDTSSWDGVNATFDDDEYLPWPYTPEKITDAYFVGCDGRTDCYNPYFYYDEAREDHLVELYHFWRTDNRTHIYNFSQFTKEYTLSMYWSAMTMTTLGEQPAPNTSLQNAFEIVNTLAGLLLFAVIMGSIGDLVANANAVKTFWQTLMDGLKQYMTYRNLNERLQTKVLKYCEYEMAEETIMKEHEVRDELPAKLYGHVTTSIIGASLVRSPLFRASERSFLNDISQLLEPHYFCPGDVVIEKGQLCSSMFIIVCGQMVEITEDNEIDHFEGEILGDVNLIWFNNHLNHNRHQHNVISSAFSQIHMLSRDDFFKVLSSYDPKLKRRLCDVAFYLQRQRGELDDKKRCLSENEDIESNLKRLAIDTLELHDKMTEMEEEFWDFSATAKRKLFESEMVVCDLLNNSQRRSR
Protein: Tudor domain-containing protein (Q19491)
Organism: Caenorhabditis elegans
Interaction partners:
- RSD-2 domain-containing protein
- ENTH domain-containing protein
- Systemic RNA interference defective protein 2
- RNA interference defective protein 10
- RNA interference defective protein 11
- Systemic RNA interference defective protein 1
- ENTH domain-containing protein
Sequence:
MNEKELADSVFGGLMAKAMGKMVHESEICPLVDQIEGKGQTNEELQGLRLSLSDLLLRHPDKFINCGNRNWRLNQNNHAFQQLAESISDKKSGKGGKRSARGGSNLPSFNRARSGGIPRNHNQTHGFRQSAPAHRGHHRPPAGNHGSSFRPNLNISQPNPSNDYSKMTGLHYPVSRNVLASNNGSNSRFSNQPPRREDHHEKMIMRTPYRDPSPRRGNNYGDIRGRPDSRDGYNGDRDSTRYSSPRRNEQPGRPSSRGSNISDYSQFSSDTNAESNTERRSRPDASSPDLADLARRFNSSSINVQPQPLESVASSDVLSKKIAKAVRKIMKKLNEGEKLSLENLFDEIERKNKILIPGKNGKEKEDFLKDLKKIMPKLLSALTIDTETGDLTWNEAAVTTDSPIHEYMEDDLHYYVVDYVKMLDKARFRVTDEAERLSNATGVRMERTCEKLTYVLFITFEGEYRYASGSKTEVLKISKITTVGDAPEFYQTSFEHKIFENVPANALVKCGIVRYQNVQKFAVRPEEYIKPYEKMNQEIQDFMSQIRNEKSVPFEMWRPNHACLVQLNDSTTILKWSRAMIIKIETQLIFLFILDSGFRKVVPSSDLRLMPQKFAKLPPFAIPCTLDESEDDKDNIEFGGKEYLSNGPGNLSVTCSGAATASDGILTYPIKLFSTCHGGPLTNIKDVFI
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit) (A0A0S2Z433)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU367010}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU367010}; Matrix side {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU367010}.
Interaction partners:
Sequence:
MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK
Protein: Solute carrier RCH1 (Regulator of calcium homeostasis 1) (Q05131)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Solute carrier protein that negatively regulates the cytosolic calcium homeostasis in response to high levels of extracellular calcium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26832117}; Multi-pass membrane protein {ECO:0000255}. Bud neck {ECO:0000269|PubMed:26832117}. Note=Distributes as multiple foci in the plasma membrane prior to cell division, moves toward and concentrates at the bud neck as the bud grows in size, and disperses again along the plasma membrane immediately prior to cytokinesis. {ECO:0000269|PubMed:26832117}.
Interaction partners:
- Divalent cation/proton antiporter GDT1
- Protein BOP2
- Uncharacterized protein YDR366C
- Uncharacterized protein YJL107C
- GID complex substrate-recognition subunit 10
Sequence:
MKTQYSLIRKIWAHSVTEFLKSQWFFICLAILIVIARFAPNFARDGGLIKGQYSIGYGCVAWIFLQSGLGMKSRSLMANMLNWRAHATILVLSFLITSSIVYGFCCAVKAANDPKIDDWVLIGLILTATCPTTVASNVIMTTNAGGNSLLCVCEVFIGNLLGAFITPALVQMFTNRAPFAYGNPATGNGIGALYGRVMKQVGLSVFVPLFVGQVIQNCFPKGTAYYLGFLKKYHIKIGSYMLLLIMFSSFSTAFYQDAFTSVSHVCIIFLCFFNLGIYIFFTGLSYLCARPWFILKLFPHEPIEGKSTRLYRYSYNIFRPFYYSKEDAICIMFCGPAKTAALGVSLITSQYGDKKEHLGKLLVPLVLYQVEQVMTANFFVSLFKRWIQKDAQADGSESSCANENEEVDLEKIISIGTGENQSVLSNNVPYTQPR
Protein: histidine kinase (EC 2.7.13.3) (Q89YR8)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Two-component system sensor histidine kinase/response regulator, hybrid
- histidine kinase
- histidine kinase
- Two-component system response regulator
- histidine kinase
Sequence:
MSKLKKIVIYLFFLCLGMHSAFSETPEQITFSYISINEGLSQSTVFSIDQDKRGNMWFATYDGVNKYDGYAFTVYQHNEDDPNSIANDISRIVKTDSQGRVWIGTRDGLSRYDEEKDIFQNFFYEKNGKHLQVNGIEEISPEQLLISTPEGLIMFDIKESKFIDDSFSTAMHKTIASTLYRQGDQIYIGTSTDGLYTYSITQKTFEKVIPILGTKQIQAILQQSPTRIWVATEGAGLFLINPKTKEIKNYLHSPSNPKSISSNYIRSLAMDSQNRLWIGTFNDLNIYHEGTDSFASYSSNPVENGSLSQRSVRSIFMDSQGGMWLGTYFGGLNYYHPIRNRFKNIRNIPYKNSLSDNVVSCIVEDKDKNLWIGTNDGGLNLYNPITQRFTSYTLQEDESARGIGSNNIKAVYVDEKKSLVYIGTHAGGLSILHRNSGQVENFNQRNSQLVNENVYAILPDGEGNLWLGTLSALVRFNPEQRSFTTIEKEKDGTPVVSKQITTLFRDSHKRLWIGGEEGLSVFKQEGLDIQKASILPVSNVTKLFTNCIYEASNGIIWVGTREGFYCFNEKDKQIKRYNTTNGLPNNVVYGILEDSFGRLWLSTNRGISCFNPETEKFRNFTESDGLQSNQFNTASYCRTSVGQMYFGGINGITTFRPELLLDNPYTPPVVITKLQLFNKVVRPDDETGILTKNISETKSITLKSWQTAFSIEFVVSNYISGQHNTFAYKLEGYDKEWYYLTDSRTVSYSNLPQGTYQFLVKAANSDGKWNPIPTALEIIVLPIWYKTWWALLIFFATFAGFITFVFRFFWMRKSMEAQLEIERRDKEHQEEINQMKMRFFINISHELRTPLTLILTPLQEIINKISDRWTRNQLEYIQRNANRLLHLVNQLMDYRRAELGVFELKAKKGNAHQLIQDNFLFYDKLARHKKITYTLHSELEDKEVLFDANYLELIVNNLLSNAFKYTESGQSITVTLKEENGWLLLQVSDTGIGIPINKQGKIFERFYQIESEHVGSGIGLSLVQRLIELHHGRIELDSEENKGSTFSVYLPQDLSVYKPSELASNNEQNEEEQVYSTNSKAMYFIDTEKVENESVESGDKKRGTILIVEDNNEIRRYLSNGLADLFNTLEAGNGEEALEKLKDNEVDVIVTDVMMPVMDGIKLCKNVKQNIRTCHIPVIILSAKTDIKDQMEGLQMGADDYIPKPFSLAILTTKIQNMMRTRRRMLDKYAKSLEVEPEKITFNAMDEALLKRAMAIVEKNMDNIEFSTDEFAREMNMSRSNLHLKLKAITGESTIDFIRKIRFNEAAKLLKDGRYTVAEVSTMVGFNTPSYFATSFKKYFGCLPTEYIKKSKG
Protein: Probable transcription factor At3g04930 (Storekeeper-like protein At3g04930) (Q9CAV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription factor STKL1
- Transcription factor
- B3 domain-containing protein At5g60142
- Sequence-specific DNA binding transcription factor
- Trihelix transcription factor ASIL2
- Protein LOL2
Sequence:
MTSDHRDALFSLELESPDPDEGGVADGGESDTDEDLRDNDDVVMPGTNEAEAEDDDPEEEDLNSPSTSSLPMVSTISATAVVSGTPTATSSTGAVTVALPAGSAVPVSVIPVDSDPKWHRMTEIVHQRPPIDDSRRLFQRLWTDEDEIELLRGFLDYMTMHRGSSSHPPDTAPFYEQIKSKLQLDFNKNQLVEKLRRLKKKYRNVMSKISSGKEVFFKSPHDQSTFEISRKIWNQTGKIIGFEDNNVMDFEETNNHHNTTNGNYSTFNSPSSNPTLELDSENGIEKKLTMSSSSVSRKRSRSRIGKIEEDNKPVITPSDGPIASNVNLNEAAAVGIGGNLGGLIEETVKNCVSPVIKEMMNGTTSMMMAAMGGGFPGLGGGGGGGGGHGFGSLSPMFTRPFNFGFGVEGGGNKAVADERWRKQQILELEVYSRRLELVQEQIRTTLNELKTMPSGI
Protein: Alpha-1-macroglobulin (Alpha-1-M) (Alpha-1-macroglobulin 165 kDa subunit) [Cleaved into: Alpha-1-macroglobulin 45 kDa subunit] (Q63041)
Organism: Rattus norvegicus (Rat)
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:1725450}.
Interaction partners:
- Prothrombin
- Albumin
- Beta-2-glycoprotein 1
- Histidine-rich glycoprotein
- Haptoglobin
- Vitamin D-binding protein
- Protein AMBP
- Prolow-density lipoprotein receptor-related protein 1
- Plasminogen
- Ceruloplasmin
Sequence:
MRRNQLPIPVFLLLLLLLPRDATAATGKPRYVVLVPSELYAGVPEKVCVHLNHLNETVTLNVTLEYGVQYSNLLIDQAVDKDSSYCSSFTISRPLSPSALIAVEIKGPTHHFIKKKSMWITKAESPVFVQTDKPIYKPGQTVKFRVVSVDISFRPVNETFPVVYIENPKRNRIFQWQNVDLPGGLHQLSFPLSVEPALGIYKVVVQKDSGKKIEHSFEVKEYVLPKFEVQVKMPKTMAFLEEELVVTACGLYTYGKPVPGLVTMKVCRKYTQSYSNCHGQHSKSICEEFSKQADEKGCFRQVVKTKVFQPRQKGYDMKIEVEAKIKEDGTGIELTGTGSCEIANTLSKLKFTKANTFYRPGLPFFGQVLLVDEKGQPIPNKNLTVQVNSVRSQFTFTTDEHGLANILIDTTNFTFSFMGIRVIYKQNNICFDNWWVDEYHTQADHSAARIFSPSRSYIQLELVLGTLACGQTQEIRIHFLLNEDALKDAKDLTFYYLIKARGSIFNSGSHVLPLEQGKVKGVVSFPIRVEPGMAPVAKLIVYTILPNEELIADVQKFDIEKCFANTVNLSFPSAQSLPASDTHLTVKATPLSLCALTAVDQSVLLLKPEAKLSPQSIYNLLPQKAEQGAYLGPLPYKGGENCIKAEDITHNGIVYTPKQDLNDNDAYSVFQSIGLKIFTNTRVHKPRYCPMYQAYPPLPYVGEPQALAMSAIPGAGYRSSNIRTSSMMMMGASEVAQEVEVRETVRKYFPETWIWDMVPLDLSGDGELPVKVPDTITEWKASAFCLSGTTGLGLSSTISHKVFQPFFLELTLPYSVVRGEAFILKATVLNYMPHCIRIHVSLEMSPDFLAVPVGSHEDSHCICGNERKTVSWAVTPKSLGEVNFTATAEALQSPELCGNKVAEVPALVQKDTVVKPVIVEPEGIEKEQTYNTLLCPQDAELQENWTLDLPANVVEGSARATQSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGSYSTFGDRGMRHSQGNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGVDDEVTLSAYITIALLEMPLPVTHSVVRNALFCLETAWASISNSQESHVYTKALLAYAFALAGNRAKRSEVLESLNKDAVNEEESVHWQRPKNVEENVREMRSFSYKPRAPSAEVEMTAYVLLAYLTSASSRPTRDLSSSDLTTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKYGAATFTKSNKEVSVTIESSGTVSGTLHVNNGNRLLLQEVRLADLPGNYITKVSGSGCVYLQTSLKYNILPEAEGEAPFTLKVNTLPLNFDKAEHHRKFQIHINVSYIGERPNSNMVIVDVKMVSGFIPVKPSVKKLQDQSNIQRTEVNTNHVLIYIEKLTNQTMGFSFAVEQDIPVKNLKPAPVKVYDYYETDEFAIEEYSAPFSSDSEQGNA
Protein: Phosphoprotein 85 (pp85) (Phosphoprotein UL25) (F5HGJ4)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Subcellular location: Virion tegument {ECO:0000305}. Host cytoplasm {ECO:0000250}. Note=Expressed exclusively at the cytoplasmic level during the late phase of the virus replication cycle. Also found in dense bodies (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MSSRRRSSSRRSGEPSTVIYIPSSNEDTPADEEAEDSVFTSTRARSATEDLDRMEAGLSPYSVSSDAPSSFELVRETGGTGAAKKPSEKKRSSSRRQPQIAAGAPRGSPATPKAGKSPKVSRPPSVPSLPENGAGGGGDDNSSSGGSSSRTTSNSSRSTSPVAPGEPSAAEGDEFSFCDSDIEDFERECYRVSVADNLGFEPSVVAPQHVEYLKFVLQDFDVQHLRRLNECIPMPAFALTSLVDPVLNNVAPGERDLTRRIITHAVIINYYYVAQKKARHMVEAIRTTVRGDTVRRVAAQVNNQSRSGRAAALALHFLTSRKGVTDGQYATSLRRLDEELRHRGTPESPRLTEVYQTLRDYNVLFYTAHYTSRGALYLYRQNLQRLNENHRGMLRLLSVEEICEEHTLNDLAFLVGVELMITHFQRTIRVLRCYLQHQLQSISELCYLIYVQLPSLREDYAQLSDVIYWAVSQNYDYALYASTPALFDFLRVVRQQDAFICTDYVYCALRLLACPDRPIIGDTGGSSSSQRLVGEFMVRDPLLRDPRATHLRQKLITRDICVARLQAQPSSRHIPVEHTGVSSVTLLKIFSQVPPDEREEDTLREMALKAFMEANGNHPEQICRSPPPPLPPRDYPQRDERDRHRRDRRDSGEYCC
Protein: Pyruvate dehydrogenase E1 component subunit beta (EC 1.2.4.1) (Q6FMM4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Dihydrolipoyl dehydrogenase
- Pyruvate dehydrogenase E1 component subunit alpha
- Acetyltransferase component of pyruvate dehydrogenase complex
- Candida glabrata strain CBS138 chromosome G complete sequence
- Malic enzyme
- dihydrolipoyllysine-residue succinyltransferase
- Glutathione reductase
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase
- Pyruvate kinase 2
Sequence:
MLQFRTPLTRLTPMARLATRSAVRMASTKTMTVREALNSALAEELDRDDDVFIIGEEVAQYNGAYKVTKGLLDRFGERRVVDTPITEYGFAGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQIVFRGPNGSAVGVAAQHSQDYSAWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYGEQFEVSEEALSPDFTLPYTAKVEKEGKDISIITYTRNTEFSLAAAKILEEKYGVSAEVINLRSIRPLDIDAIVKTVKKTNHLITVESTFPSFGVGAEIIAQVMESEAFDYLDAPIQRVTGADVPTPYAKELEDFAFPDPETIVRAAKEVLSIE
Protein: MDS1 and EVI1 complex locus protein EVI1-A (Ecotropic virus integration site 1 protein homolog-A) (Evi-1) (xEvi-1) (B7ZRU9)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor during pronephros development. Plays a role in regionalization of the pronephros; may promote formation of the distal tubule and duct over formation of the glomus and proximal tubule.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q03112}. Nucleus speckle {ECO:0000250|UniProtKB:Q03112}.
Interaction partners:
Sequence:
MKSEDYSYARMAPDIHEERQYRCEECDQLFESKTELSDHQKYPCVTPHSAFSLVENSFPPSLNDDSDLTEMQHTHECKECDQVFPDMQSLEKHLLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDTGKHYECENCSKQVFTDPSNLQRHIRSQHVGARAHACSDCGKTFATSSGLKQHKHIHSSVKPFVCEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGLFGQGISLPGTPAMDKASMISMNHANAGLADYFGASRHTAGLTFPTAPGFPFSFPGLFPSSLYHRPPFIPPASPVKGLPGVEQSSKSQSPHVNQPQVLPATQDILKALSKHPSVDENKALEFITESNLNQRPHEKISDHSESSDLDDVSTPSGSDLETTSGSDLESDIESDKDKLKENGKLYKDKMSPLQSLAALNSKREYNNHSVFSPCLEEQTAVTGAVNDSIKAIASIAEKYFGSTGLVGLPDKKGTTLPYPSMFPLPFFPAFSQSMYTFPDRDVRPVPLKIEPESPKETKKVQKGKTESPFDLTTKRKEEKASPNVPSKSGAPTSSNHDQPLDLSMGSRSRAATTKQTEPRKNHIFNEKKDMDPELPKTSEHCLQHARPAPFFMDPIYRVEKRKPMDPLEILKEKYLRPSPGFLFHPQFPMPDQRTWMSAIENMAEKLESFNALKPEANNLIQSVPSMFNFRASSSALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNLSGTAASSPHSEIEGTGPILDEKEDSYFNEIRNFIGNSSHNKQSPLNSDERINGSHDKIMLAGQNSDILDDDEDEAILDEDDEESDIAVKVMKEPNTSVMLEKCSVDEYEEGGKSEVNSKVSPSRYDDEDDDDDEEEDFKKSLSALDHIRHFTDSLKMRKMDDGQFNDAELSAFTASHLTDDLKHPLYRKSKSQAYAMMLSLSDQESLHPTTHTSSSMWHNLARAAAESTALHSVSHV
Protein: GM10074p (Q8MZ51)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGEVQWLRNGEEIKPDKRIQIVKDGRKRKLVIKDCKVTDAGQFKCTTNADTTESEIIINYQNRFNKKLKDTEAVEREKLILDIELQDQTAPCDWKFNGEPIVPSESIEIKNMGGGKHQLIFSSLDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSGPISAPVLLEVPFKVSGTKQTPVEAKLFKDGKPLPVKDVEVAVTDDKVTFKIKKPSRDLSGPYQIKISNGQGEDTKDVQIICQDVPQPPQDVDITDVYQTSCVVSFNPPSDDGGTPITKYVIERQDLSKKHGWESVAEVLPSEPCLKKKKKK
Protein: dynamin GTPase (EC 3.6.5.5) (Q9U9I9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSWQNQGMQALIPVINRVQDAFSQLGTSVSFELPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLIQDRNEYAEFLHKKGHRFVDFDAVRKEIEDETDRVTGQNKGISPHPINLRVFSPNVLNLTLIDLPGLTKVPVGDQPADIEQQIRDMILTFINRETCLILAVTPANSDLATSDALKLAKEVDPQGLRTIGVLTKLDLMDEGTDAREILENKLFTLRRGYVGVVNRGQKDIVGRKDIRAALDAERKFFISHPSYRHMADRLGTSYLQHTLNQQLTNHIRDTLPTLRDSLQKKMFAMEKDVAEYKNYQPNDPGRKTKALLQMVTQFNADIERSIEGSSAKLVSTNELSGGARINRLFHERFPFEIVKMEIDEKEMRKEIQYAIRNIHGIRVGLFTPDMAFEAIAKKQITRLKEPSLKCVDLVVNELANVIRQCADTMARYPRLRDELERIVVSHMREREQIAKQQIGLIVDYELAYMNTNHEDFIGFSNAEAKASQGQSAKKNLGNQVIRKGWLSLSNVSFVRGSKDNWFVLMSDSLSWYKDDEEKEKKYMLPLDGVKLKDIEGGFMSRNHKFALFYPDGKNIYKDYKQLELGCTNLDEIDAWKASFLRAGVYPEKQKAQEDESQQEMEDTSIDPQLERQVETIRNLVDSYMRIITKTIKDLVPKAVMHLIVNQTGEFMKDELLAHLYQCGDTDALMEESQIEAQKREEMLRMYHACKEALPIISEVNMSTLGDQPPPLPMSDYRPHPSGPSPVPRPAPAPPGGRQAPMPPRGGPGAPPPPGMRPPPGAPGGGGGMYPPLIPTRVPTPSNGAPEIPARPQVPKRPF
Protein: Histone H3.3B (H3.B) (C0HL67)
Organism: Drosophila melanogaster (Fruit fly)
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Interferon regulatory factor 6 (IRF-6) (O14896)
Organism: Homo sapiens (Human)
Function: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}.
Interaction partners:
- Grainyhead-like protein 3 homolog
- Homeobox protein MSX-1
- Transcription factor MafB
- Ventral anterior homeobox 1
- Receptor-interacting serine/threonine-protein kinase 4
- Nectin-1
- Paired box protein Pax-9
- U3 small nucleolar RNA-associated protein 25 homolog
Sequence:
MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ
Protein: dynamin GTPase (EC 3.6.5.5) (Q5AFB7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Mitofusin
- Mitochondrial fission 1 protein
- Fgr32p
- Clathrin heavy chain
- Rhomboid protease
Sequence:
MIPRNGRLIMKSRALPLRTFVLLRSSAHNTHFKNVSTFVPTRNLGFLKVLTRAVKMPAYIGGTMAAGGTYVAYKVEQASSYTQDKLSAFKDFADGVFDKTGDFFKNLGGTDGATGGNGAEDGASSGGAGGGGGGGGGGNDTATAVGATAAAVGLTSDEDESTEAETDIEEEDEETLIEDDSDDDDDLANDETDDHMLNLTRQMIEIRNLLSSLNHDGIKLPSIVVIGSQSSGKSSVLESVVGQEFLPKGSNMVTRRPIELTLVNTPEAAANVAEFPALKMYNLTDFQQVQKILFDLNMAVPASECISNDPIQVTIRSPTVPDLSLVDLPGYIQVEAADQPIELKTKIRELCNRYLEPPNVILAISAADVDLANSAALRASRLADPRGERTIGVVTKLDLVDPEQARKILLNKKYPLKLGYVGVITKAPHPKASASGLFSRKQVTGYQAFVAQQNFEHTFLKENKEAFFGCTVGTRNLKKKLMKVLEKTMAASLRPTHLAIQQELEETSYQFKVEFNDRPLTPQMYLANNIDMLKLGTKDLSHNFSRNELKAILKNALDQKVLDLMAERYWNKPFELKGSSVEPDLRELTQINIDNDIYWHKKLDLTTSSLTKLGVGRLSTNLITNALLTEIDNLVDNTQLRNHPMAKSAVRDAARSVLGNKYYSTADQVENCIKPYKYEIELEDREWQTSKENAVTLLKEEMRQCEEVYHDLKSQVGGRKLQQVVTYLEKLKQSNNSDVDLTTNETLGFSPTLIQRGKEAIFLKERISLLKMRYQFVKNSKKCKKKESKYQCPEIFLDAVASKITSTSILFLNVELLSDFYYNFPRELDLKFFNNLSKDEIEKFAKEDPKIKKHIELQERKDLLENALSKVESVLAVQRTTQKDNTEDRNKKSVFGW
Protein: Myocyte enhancer factor 2cb (F1QNL1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESKDKYREINDDIDLHMISRQRICAVPSSTYDMTIPVNNQIYPGNHNLLPLAHHGLQRNSMSPGVTHRPPSAGGLMGTDLSTGAGTSAGKDGIPTYYRNGYGNHRNSPGLLVSSGGMNKSMQAKSPPPVNLGMNSRKPDLRVLIPPGAKNNMPSINQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTSYGTEYSLSSADLSSISGFNSANTLHLGSMSGWQQHQIQNMQHSALSQLGNCSSSHLCQGSNLSLPSTQSLHIKSEPVSPPRDRSSSTTPGGYGQLPSHQQHQGPTSQGRQDSGRSPADSLSSCGSSHEGSDRDEHRPDFHSPLGLGRPGLDDQDSPSIKRIRLSEGWAT
Protein: Activated in Blocked Unfolded protein response (Q86S74)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRFIAIAALLASSFLLIEATATSTREKRQSCGCAPRVQPSCSCQQTTYAQPPQYSCSCQNTAPVQTSCSCAQPVQQQTYQVQASQCAPACQQSCQMQCQSAPSVSQCQSTCQQSCQASSCYTPAPVQCQPSCMPACKQSCVAPAPQIISLNLEVVPQCQQQCAPQCQQASAPQCQQCQNTCQQFAPVCQQQCAPQCTISSAPQCQQCQTTCQQFAPVCQQQCAPQCQQPSAPQCQQCQSACQSPVVAPVVAPQIVTVILEASVSQSAQCEPECQQSCQQQCVQQQQPMIQCAPACTQSCSQSCSIAQPAQMPCMTESINSCSCQQNYSPCGNGQCCKRK
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (A0A8I5ZWJ2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR000632}.
Interaction partners:
Sequence:
MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKSQYRTLTRDSAQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHYHQFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSAPDVPPCVTFDVSLLEEGEQLEPGDLQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQCEEQNTHPRERVQLLGKRQVLQEAMQGLQVALCNQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQERDGGRTPTLEIIKSHFSGIFRPKFSIPPPLQLVPEVQKPLHEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGKATDL