wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase PCRK1 (EC 2.7.11.1) (Protein PTI-COMPROMISED RECEPTOR-LIKE CYTOPLASMIC KINASE 1) (Q9SF86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the activation of early immune responses. Plays a role in pattern-triggered immunity (PTI) induced by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Contributes to PTI in response to the bacterial pathogen Pseudomonas syringae pv maculicola strain ES4326. Contributes to PTI in response to the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000. Functions redundantly with PCRK2 in basal resistance against bacterial pathogens and in regulation of plant immunity. Functions together with PCRK2 downstream of the PAMP receptor FLS2. Contributes to the induction of SARD1 and CBP60G, which are transcriptional activator of ICS1, an enzyme involved in salicylate (SA) biosynthesis upon pathogen attack.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27208222}; Peripheral membrane protein {ECO:0000305|PubMed:27208222}.
Interaction partners:
- At1g32920/F9L11_25
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
Sequence:
MKCFLFSGGDKRGEQKTPISVSLTSIFSDREINRSGSEFNSRDVSGTSTESSMGRKNSYPPVSTRASNLREFSITDLKSATKNFSRSVMIGEGGFGCVFRGTVRNLEDSSVKIEVAVKQLGKRGLQGHKEWVTEVNFLGIVEHTNLVKLLGYCAEDDERGIQRLLVYEYMPNRSVEFHLSPRSLTVLTWDLRLRIAQDAARGLTYLHEEMEFQIIFRDFKSSNILLDEDWKAKLSDFGLARLGPSEGLTHVSTDVVGTMGYAAPEYIQTGRLTSKSDVWGYGVFLYELITGRRPVDRNRPKGEQKLLEWVRPYLSDTRKFKLILDPRLEGKYPIKSVQKLAVVANRCLVRNSKARPKMSEVLEMVNKIVEASSGNGSPQLVPLNSVKASRDARGKNNGGGGEGGWFGKLWNPKTIRAC
Protein: Vacuolar protein-sorting-associated protein 25 (O74967)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Endosome membrane {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein sorting-associated protein 20
- Vacuolar-sorting protein dot2
- Vacuolar protein sorting-associated protein 28 homolog
- ESCRT-III complex subunit did4
- Vacuolar protein sorting-associated protein 24
- Vacuolar-sorting protein snf7
- Vacuolar protein sorting-associated protein 27
- Vacuolar protein-sorting-associated protein 46
- Charged multivesicular body protein 7
Sequence:
MRVPSIYNFPPFFTRQLNDNTWHSQKAAWQMWILLWCRENRQTSITINPELLESSLLHNSTIHRTLPLSVFREIVEDMVKQNLAEWTEKRNPKDVFWVYWRSISEWGNMILKWLSDMGREGSICTFYELQEQYKEVDCLDEVLLHKVLELLMKKGNIELMKGSSGKYSGFKVLKA
Protein: WRKY transcription factor WRKY71 (OsWRKY71) (Q6QHD1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription repressor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Represses specifically gibberellic acid (GA)-induced promoters in aleurone cells, probably by interfering with GAM1. Regulates, probably indirectly, the activation of defense-related genes such as GF14E during defense response. Modulates plant innate immunity against X.oryzae pv. oryzae (Xoo). Confers resistance to the virulent bacterial pathogen Xoo 13751, probably via the regulation of NPR1 and PR1b defense signaling pathways.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223, ECO:0000269|PubMed:15047897, ECO:0000269|PubMed:16919842, ECO:0000269|PubMed:18175928}. Note=Localized in nuclei of aleurone cells. {ECO:0000269|PubMed:15047897}.
Interaction partners:
- Os09g0101800 protein
Sequence:
MDPWISTQPSLSLDLRVGLPATAAVAMVKPKVLVEEDFFHQQPLKKDPEVAALEAELKRMGAENRQLSEMLAAVAAKYEALQSQFSDMVTASANNGGGGGNNPSSTSEGGSVSPSRKRKSESLDDSPPPPPPPHPHAAPHHMHVMPGAAAAGYADQTECTSGEPCKRIREECKPKISKLYVHADPSDLSLVVKDGYQWRKYGQKVTKDNPCPRAYFRCSFAPACPVKKKVQRSAEDNTILVATYEGEHNHGQPPPPLQSAAQNSDGSGKSAGKPPHAPAAAPPAPVVPHRQHEPVVVNGEQQAAAASEMIRRNLAEQMAMTLTRDPSFKAALVTALSGRILELSPTKD
Protein: Carboxylic ester hydrolase (Q86KU7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Lipase
- Lipase
Sequence:
MGLIIVSILRTIWRWSQLYLTLSILIAERITRFFVTTIFGFVPFKYYFDNISFSKPVSKDATEAEKDLERDAIEMITARGYPVEEHFVTTPDGFILGLHRITGPKQFNTPPDSPPTSPRSNNNNNHNHSRSSNNSNGTSSSSTTTTTTTNRKSKLAQKLQQHVDIDQEIHNSNANTTTTTTTSSGNNNNNNNNMTSTDMMSSASSTSNFSIYNGKPVVVIMHGFMQTSEAWLCRSDPKDSLPFILADAGFDVWLGNNRGNKYSFKHTNYTPNQEGFWNWSLDELVRYDYPSIVNFICERTGAPSISYIGFSQGTAQGWAALSTNTVISKKINLFIALAPVATVKGFSNPMIDSLARSRPDFIFLLFGKKSMLPSTIFWRNFLPKDVFVRVIDTSVRFLFGWTTENISQQEKKMLYSHIFSYTSVKSVVHWFQIIQTNRFQMFDDILLGITPNENSKKPHRYHGRVIPGYHPAQILTKCALFYGGSDNLPNTKALLSHLPRDRVVMVHEEPSYEHLDFMWGKDAAEKVFSKVVSLLKSNHFDLTNGTYNGNTNGNNLNNNNCSSNSSPMVNTNNGSYYNSPMLTSQQNNNNNTNNNSIPLKFN
Protein: Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) (Q9Y2V2)
Organism: Homo sapiens (Human)
Function: Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21177848}. Cytoplasm, P-body {ECO:0000269|PubMed:21177848}. Cytoplasmic granule {ECO:0000269|PubMed:21177848}. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MSSEPPPPPQPPTHQASVGLLDTPRSRERSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKHETWSGHVISS
Protein: Adenylate kinase isoenzyme 6 homolog FAP7 (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (POS9-activating factor 7) (Q12055)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (By similarity). Involved in 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:10692169, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Small ribosomal subunit protein uS11A
- 20S-pre-rRNA D-site endonuclease NOB1
- Adenylosuccinate lyase
- Small ribosomal subunit protein uS11B
- Ribonucleoside-diphosphate reductase large chain 1
- Ribonucleoside-diphosphate reductase large chain 2
- Serine/threonine-protein kinase RIO2
- Adenylate kinase
- GTP:AMP phosphotransferase, mitochondrial
- Nucleoside diphosphate kinase
Sequence:
MEARRYGPNIIVTGTPGCGKSSTCEFLKNKLKDYKYYNISDFAKDNDCFEGYDEGRKSHIVDEDKLLDMLEPLLRQGNSIVDWHVNDVFPERLIDLVVVLRCDNSNLYSRLHARGYHDSKIEENLDAEIMGVVKQDAVESYEPHIVVELQSDTKEDMVSNVSRIVAWEKMWLEQHPDGVTNEYQGPRSDDEDDEDSE
Protein: Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) (P17735)
Organism: Homo sapiens (Human)
Function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Aspartate aminotransferase, mitochondrial
- Phenylalanine-4-hydroxylase
- Putative aspartate aminotransferase, cytoplasmic 2
- Aspartate aminotransferase, cytoplasmic
- Acireductone dioxygenase-requiring))
- S-adenosylmethionine synthase isoform type-1
- S-adenosylmethionine synthase isoform type-2
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- Betaine--homocysteine S-methyltransferase 1
Sequence:
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK
Protein: Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) (Q86TB3)
Organism: Homo sapiens (Human)
Function: Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:28668886}.
Interaction partners:
Sequence:
MKDSEGPQRPPLCFLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISNYEFFENQYIHVLHLSCCTKNDAAVYQISAKNSFGMICCSASVEVECSSENPQLSPNLEDDRDRGWKHETGTHEEERANQIDEKEHPYKEEESISPGTPRSADSSPSKSNHSLSLQSLGNLDISVSSSENPLGVKGTRHTGEAYDPSNTEEIANGLLFLNSSHIYEKQDRCCHKTVHSMASKFTDGDLNNDGPHDEGLRSSQQNPKVQKYISFSLPLSEATAHIYPGDSAVANKQPSPQLSSEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRNLLGTEHVFLLESDDEEMEFGEHCLGGCEHFLSGMGCGSRVSGDAGPMVATAGFCGHHSQPQEVGVRSSRVSKHGPSSPQTGMTLILGPHQDGTSSVTEQGRYKLPTAPEAAENDYPGIQGETRDSHQAREEFASDNLLNMDESVRETEMKLLSGESENSGMSQCWETAADKRVGGKDLWSKRGSRKSARVRQPGMKGNPKKPNANLRESTTEGTLHLCSAKESAEPPLTQSDKRETSHTTAAATGRSSHADARECAISTQAEQEAKTLQTSTDSVSKEGNTNCKGEGMQVNTLFETSQVPDWSDPPQVQVQETVRETISCSQMPAFSEPAGEESPFTGTTTISFSNLGGVHKENASLAQHSEVKPCTCGPQHEEKQDRDGNIPDNFREDLKYEQSISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPEPTDTALTLENVCDEPRDREAVCAMECFEAGDQGTCFDTIDSLVGRPVDKYSPQEICSVDTELAEGQNKVSDLCSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFTSTFTLNISHTASEGATGENLAKVENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGGDKSPSPSAADTTATPASYSSIVSFPWEKPTTLTANNECFQATRETEDTSTVTIATEVHPAKYLAVSIPEDKHAGGTEERFPRASHEKVSQFPSQVQLDHILSGATIKSTKELLCRAPSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQQSLSQQGSLSAPDFQQSLPTTSAAQEERNLVPTAHSPASSREGAGQRSGWGTRVSVVAETAGEEDSQALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESKASDGGLIIPDKVWAVPDSLKADAVVPELAPSEIAALAHSPEDAESALADSRESHKGEEPTISVHWRSLSSRGFSQPRLLESSVDPVDEKELSVTDSLSAASETGGKENVNNVSQDQEEKQLKMDHTAFFKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSNDGNMGHEAEIQPAILQVPCLQGTILSENRISRSQEGSMKQEAEQIQPEEAKTAIWQVLQPSEGGERIPSGCSIGQIQESSDGSLGEAEQSKKDKAELISPTSPLSSCLPIMTHASLGVDTHNSTGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPSSPDLTRFPCTSSPEGNVTDFLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKAPKLLQDPCQKGTLGCAKKSREREKSLEARAGKSPGTLTAVTGSEEVKRKPEAPGSGHLAEGVKKKILSRVAALRLKLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDPKKPSCKREGRAPVLLKKIQAEMFPEHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGPETPGEKKT
Protein: Uncharacterized protein C13G7.11 (Q10275)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Large ribosomal subunit protein mL61
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein uL22m
- Meiotically up-regulated gene 82 protein
- Large ribosomal subunit protein uL13m
Sequence:
MNVLRTQKYWVNQFAINFACRNTYVNPMFLRYFHCAVPRAISQRALKPMDIPFLQCYIEPIDNTSFFLHPFKKIRFWWRYLFYGWWNLKKNQFLIKRTFPDRDFSIAEIIQNALKLHSGVNKALANHDLQQLEELCTLRTAQILKQQALNQPKCIWKLEKHISKPKLLNLSRAQADLKGEEFFVQAVVRLHTLQSLRTDKGSPKIEKPDIENVVIQQRSWTSPIRWQLWGSVPSTPVNTVRKTLPDGQVTFVAKPSKKSFLKQLFSGKE
Protein: Myosin light chain alkali (P06742)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Myosin heavy chain, muscle
- Tropomyosin-2
- Myosin regulatory light chain 2
- Paramyosin, long form
- Troponin T, skeletal muscle
- Troponin I
- Muscle-specific protein 20
- Troponin C, isoform 2
- Troponin C, isoform 3
- Actin-57B
Sequence:
MADVPKREVENVEFVFEVMGSPGEGIDAVDLGDALRALNLNPTLALIEKLGGTKKRNEKKIKLDEFLPIYSQVKKEKEQGCYEDFIECLKLYDKEENGTMLLAELQHALLALGESLDDEQVETLFADCMDPEDDEGFIPYSQFVQRLMSDPVVFD
Protein: Crossveinless 2 (FI20152p1) (Q9W2H2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Dorsal-ventral patterning protein Sog
- Protein twisted gastrulation
- Protein decapentaplegic
- Crossveinless
- Protein 60A
- Dorsal-ventral patterning protein tolloid
- FI03225p
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
Sequence:
MCCQSSGQWKFPAQQPRKSLASRRRHTGFRPSTQLLILIAVLLALLQGRTVDAGAGDSLSGVRQSCSNEGEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPVNDCYILDKSNGTCCRRCKGCSFRGMSYESGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRCPQNHSFLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSGDCHCDSFAAYAHECRRLGVQLPDWRSATNCPAGWRRNATLSSFKGNQFYGDPSFSRMKGRRQKNHQLRLQLQQEQQQRSKQGQKGRHKPGGHNQLDRQGHNGLDKDQLQKEFILKHVPSSFLYPRAPDRTPPPLH
Protein: RNA-binding protein FXR2 (FXR2P) (Q9WVR4)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein.
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q61584}. Cytoplasm {ECO:0000269|PubMed:11875043}. Postsynapse {ECO:0000269|PubMed:27770568}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Localization to the post-synaptic region is dependent on FMR1 (PubMed:27770568). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:27770568}.
Interaction partners:
- Cytoplasmic FMR1-interacting protein 2
- Cytoplasmic FMR1-interacting protein 1
- RNA-binding protein FXR1
- Fragile X messenger ribonucleoprotein 1
- Protein argonaute-2
- Poly
- Cytoplasmic polyadenylation element-binding protein 1
- Transcriptional activator protein Pur-alpha
- FMR1-interacting protein NUFIP1
- Heterogeneous nuclear ribonucleoprotein K
Sequence:
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWCLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNSSSLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRDLVGKVTGKTGKVIQGIVDKSGVVRVRVEGDNDKKNPKEGGMVPFIFVGTRENISNAQALLEYHLSYLQEVETLRLERLQIDEQLRQIGAGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSDPSTASETESEKREESNRAGPGDRDPPSRGEESRRRRLGPGKGPPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGALESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPLGRTEPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS
Protein: Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Q62682)
Organism: Rattus norvegicus (Rat)
Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase gamma
- Amyloid-beta precursor protein
Sequence:
MMLSWKQLILLSFIGCLAGELLLQGPVFVKEPSNSIFPVGSEDKKITLNCEARGNPSPHYRWQLNGSDIDTSLDHRYKLNGGNLIVINPNRNWDTGSYQCFATNSLGTIVSREAKLQFAYLENFKSRMRSRVSVREGQGVVLLCGPPPHSGELSYAWVFNEYPSFVEEDSRRFVSQETGHLYIAKVEPSDVGNYTCVVTSTVTNARVLGSPTPLVLRSDGVMGEYEPKIELQFPETLPAAKGSTVKLECFALGNPVPQINWRRSDGMPFPTKIKLRKFNGVLEIPNFQQEDTGSYECIAENSRGKNVARGRLTYYAKPYWVQLLKDVETAVEDSLYWECRASGKPKPSYRWLKNGDALVLEERIQIENGALTIANLNVSDSGMFQCIAENKHGLIYSSAELKVLASAPDFSRNPMKKMIQVQVGSLVILDCKPSASPRALSFWKKGDTVVREQARISLLNDGGLKIMNVTKADAGIYTCIAENQFGKANGTTQLVVTEPTRIILAPSNMDVAVGESIILPCQVQHDPLLDIMFAWYFNGTLTDFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAAELIVRGSPGPPENVKVDEITDTTAQLSWTEGTDSHSPVISYAVQARTPFSVGWQNVRTVPEAIDGKTRTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAAPEVAPSEVSGGGGSRSELVITWDPVPEELQNGGGFGYVVAFRPLGVTTWIQTVVTSPDNPRYVFRNESIVPFSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSHISAHSLSSSEIEVSWNTIPWKSSNGRLLGYEVRYWNNGGEEESSSKVKVAGNQTSAVLRGLKSNLAYYTAVRAYNTAGAGPFSATVNATTKKTPPSQPPGNVVWNATDTKVLLNWEQVKALENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELLLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDARGSTSAISDIHPVSGYISVLLFFIVNALW
Protein: Adhesion G protein-coupled receptor L3 (Latrophilin-3) (Lectomedin-3) (Q80TS3)
Organism: Mus musculus (Mouse)
Function: Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22405201, ECO:0000269|PubMed:24739570}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:22405201}. Cell junction {ECO:0000269|PubMed:22405201}.
Interaction partners:
- Leucine-rich repeat transmembrane protein FLRT3
- Teneurin-2
- Teneurin-1
- Netrin receptor UNC5D
- Teneurin-3
- Teneurin-4
- Netrin receptor UNC5C
- Netrin receptor UNC5A
- Vascular endothelial growth factor B
- UNC5C-like protein
Sequence:
MWPPQLLILTMLLAPVVHGGKHNERHPALAAPLRHAERSPGGALPPRHLLQQPAAERSTAHRGQGPRGAARGVRGPGAPGAQIAAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGPVHHGQVSYISPPIHLDSELERPPVRGISTTGSLGMGSTTTSTTLRTTTWNIGRSTTASLPGRRNRSTSTPSPAVEVLDDVTTHLPSAASQIPAMEESCEAVEAREIMWFKTRQGQVAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIAGGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNMMNKLVNNLGSGSEDDAIVLDDAASFNHEESLGLELIHEESDAPLLPPRVYSTDNHQPHHYSRRRFPQDHSESFFPLLTDEHTEDLQSPHRDSLYTSMPALAGVPAADSVTTSTQTEAAAAKGGDAEDVYYKSMPNLGSRNHVHPLHAYYQLGRGSSDGFIVPPNKDGASPEGTSKGPAHLVTSL
Protein: FI18806p1 (Uncoordinated 79, isoform D) (E1JIQ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTGSFKVQLINMGTRAAAFQAKLRALHEYHVRLLHNVLPAPSGVDIANNIKYFSQTLLTVLKDVRTSPHELIRDPLEDPTRMSAYPNLEYGNLYNALTMLIDVAPCIQYGQIVFGKALLQCLSCILPFLDKDLIDNLPYLVSSTISVLPPALHQCIINALCYYILPFTITRRSSDEQECQACQSVSSVIMMVLQYSNNPAHHCQLLECLMTLKHNVVKDILCVVAYGTAVSRTSAAKLLFYYWPAFNANLFDRKVLLSKLTNDLVPFTCQREHCPNSGNAEAAKVCYDHSISIAYAPDCPPPLYLCIECANEIHREHGSLEFGDILHPMQQVSMVCENKNCRSNEKSAFSICFSTECASFNGNHPIRYCSQCHSNRHNSRRGGDHVVHRSLQPAWQMDPEMQMHMVESVVSLLREAKPLNFEPGKESSSSESKKNGSGITADNISLEERQRLGRYGIWLLVGRCTPTADTPVEVLGRILSMLFHWFHVTAYSYDAAGQVESTIEKLKVDHVCNWLKDICRIHYNVFISCLLPHPPEYARVGGHWETLASRTSHLKEGLQRLICLVPYEVITSEIWDYVMPHWMEAITNDVAEKELNELKIVLSKILDPEMSPLGFDAKTMYNFVAIRFEKTTAKVQQQALHWLQILTKLEILIPLVQLFAMFGDGVRIMKYGIQHELMREKDAQSQSLAKAPKTPCKESKETKADMANPPRRSSISPVVEDDSGNTSAISDDEAPTNRHTEFSTDAEHNLTCCILMLDILLKQMELQDVEQHMGIHTSVCENVSRLIKCMVTAARVGLSSHVCALKVAECAYCEASIMWHQLATKLVQFMAPLNPVRPPDVPIEDIIEEEKSSRKSPPESDKEKTRDRDVSLSMAPLPIPLGPLGGFAGTLQAFQRISPFTSRPLNEPPLYHKVYKVPTKFLFQNQPKTYPLINKLTTVTVKQ
Protein: Protein interacting with Ttk69 and Sin3A, isoform D (B7Z143)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- FI11056p
- Tondu-domain-containing growth inhibitor, isoform A
Sequence:
MSLQTKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAPDGSAGNSLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSFDASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHVSSTTVTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNSVAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES
Protein: Probable TonB-dependent receptor (Q9HWM5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}.
Interaction partners:
- Luciferase-like domain-containing protein
- Probable transcriptional regulator
Sequence:
MNARTHRKLNRGIGVVTLSTLLASPSALARENPPAEDEPAALEALVVTGEKRERSLKDTASSVSLTSARDIDRKQTGNASVAEVINGSPNVVYTDSVGAPIIRGQDTQGPNNGQNVFWGGTVPRATINLDGHYLNYNEMFFGATSVWDVDSIEVFRGPQTTSQGANAIAGAIIVNTKDPTFSPEAAYQAEIGSYHSRRSSIAVSGPLAQDFAGRLAVDYAGRDTFIDYDNPKFQDSGTDQDFRALNARAKLLWLPSGIPGLESKFTFSHNDNNRPTQEAATRPFDKLDHRSTTMPSWEQDTNTSILDVAYDLDNGIRLFNQAQYSLSSVHRTTGAGGEGDADIRQKNASNESRISFGEQEDRISGMGGVYYARTRTDETLHLRGLSAFDDTKKNLGVFGELNYRLSDRWTLTTGLRYQEDRIERSGNSVLAPRPLDYQKTFSAFLPKVSLAFAATPDWTVGGLVSRGYNPGGVSLNLTTRNWAYFKEETIWNYELFTRASLLDGRLLLNGNLFFMDFKDAQYNIPVVVSPGVAQSYTINAEKAHAYGMELDLDYRLRDDLRLKASAGVLRTRIDEMSGNTGYEHNEFARSPGYTLSFGPSWDVTERLNLNAQVRYLDGYYSDTANTKAYSIKAYTLTDARASYRFNDQVQLYGYVKNVFDDRSPTYMQENRGIGGIEASMTQPRTLGIGIKGTF
Protein: Phospholipid phosphatase 4 (EC 3.1.3.4) (EC 3.6.1.75) (Q0VBU9)
Organism: Mus musculus (Mouse)
Function: Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q5VZY2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
- Phosphatidate phosphatase LPIN1
- 2-acylglycerol O-acyltransferase 1
- Phosphatidate phosphatase LPIN3
- Phospholipid phosphatase 2
- Phosphatidate phosphatase LPIN2
- Patatin-like phospholipase domain-containing protein 2
- Diacylglycerol O-acyltransferase 1
- Diacylglycerol O-acyltransferase 2
- 2-acylglycerol O-acyltransferase 2
Sequence:
MRELAIEIGVRALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMNSEMRCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLRVPTSLKKEERPTADSAPSLPLEGITEGPV
Protein: Odorant-binding protein 56i, isoform B (A0A0B4JD42)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVCVQRTQVQAGPIKDQCMAAAGITAQDVANRHETDDPGHSVKCFFRCFLENIGIIADNQIIPGAFDRVLGHIVTAEAVERMEATCNMIKSETSHDESCEFAWQISECYEGVRLSDVKKGQRTRNHRG