wanglab/gogpt-training-data huggingface dataset:
Protein: Fibroblast growth factor receptor (EC 2.7.10.1) (Q9JHX9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MVVPACVLVFCVAVVAGVTSEPPGPEQRVGRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTLWAKDGVGLVASHRILVGPQRLQVLNATHEDAGVYSCQQRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSIPWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDRELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELMEVDEAGSVYAGVLSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGGPRT
Protein: Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Human epidermal retinol dehydrogenase) (hRDH-E) (Microsomal NAD(+)-dependent retinol dehydrogenase 4) (RoDH-4) (Short chain dehydrogenase/reductase family 9C member 8) (Sterol/retinol dehydrogenase) (O75452)
Organism: Homo sapiens (Human)
Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.
Subcellular location: Microsome membrane {ECO:0000269|PubMed:9677409}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O54909}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Lecithin retinol acyltransferase
- Cytochrome P450 26A1
- Retinal dehydrogenase 2
- Retinaldehyde dehydrogenase 3
- Aldehyde dehydrogenase 1A1
- Beta,beta-carotene 15,15'-dioxygenase
- Aldehyde oxidase
- All-trans-retinol 13,14-reductase
- Diacylglycerol O-acyltransferase 1
- Cytochrome P450 27C1
Sequence:
MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIMYWVSPSPAKAL
Protein: GTP-binding nuclear protein GSP2/CNR2 (P32836)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Not essential for cell viability.
Subcellular location: Nucleus.
Interaction partners:
- Exportin-1
- Guanine nucleotide exchange factor SRM1
- Exportin-T
- GTP-binding nuclear protein GSP1/CNR1
- Ran GTPase-activating protein 1
- Nucleoporin NUP2
- Protein MSN5
- Ran-specific GTPase-activating protein 1
- Importin beta-like protein KAP122
- Importin subunit beta-1
Sequence:
MSAPAQNNAEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMHQYQQEMDQATALPLPDEDDADL
Protein: GH03582p (Q8MRR2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
HGHIQEDIKPVPPPIETIPGKKPAEKRQRPTLPKLYIKNAHSAGSSSNGNSTGTTHSTSHSHSHSHSHVHSHSHGQSQSQQQPPTPNGNTGNAVANAAASAVAAAHHGSHGSHGSHLHPHPHASVHPHPHPHHGKVLTPNNHLPSKEALEPQSPLFHIRYKSLSSLQLTPDNNNCSSVTPPTISAHGKSSGAGVGSGATASGTPGTPGTPPDVGLKCGSILNVHGYLSSPHPLPLPLPHSRSSSSNNHHNPREGTLDSSRSGGRTSGDSNKLPEKKTRRLSRPRSLSNLVWDLRPSKEKSKKKLYIHHFDQRQQATLYL
Protein: Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) (Q9NWZ3)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21325272}.
Interaction partners:
- Toll-like receptor 4
- Myeloid differentiation primary response protein MyD88
- NF-kappa-B essential modulator
- Interleukin-1 receptor-associated kinase-like 2
- TNF receptor-associated factor 6
- Interleukin-1 receptor-associated kinase 1
- Interferon regulatory factor 7
- Interleukin-1 receptor type 1
- E3 ubiquitin-protein ligase pellino homolog 1
- Toll/interleukin-1 receptor domain-containing adapter protein
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Protein: PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27) (O75915)
Organism: Homo sapiens (Human)
Function: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ES40}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ES40}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. {ECO:0000250|UniProtKB:Q9ES40}.
Interaction partners:
- Excitatory amino acid transporter 3
- Prenylated Rab acceptor protein 1
Sequence:
MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLTDYISKVKE
Protein: Guanine nucleotide-binding protein subunit alpha (B7Z581)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYGGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Protein: Ribonuclease E (RNase E) (EC 3.1.26.12) (P21513)
Organism: Escherichia coli (strain K12)
Function: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Can also process other RNA species, such as RNAI, a molecule that controls the replication of ColE1 plasmid, and the cell division inhibitor DicF-RNA. It initiates the decay of RNAs by cutting them internally near their 5'-end. It is able to remove poly(A) tails by an endonucleolytic process. Required to initiate rRNA degradation during both starvation and quality control; acts after RNase PH (rph) exonucleolytically digests the 3'-end of the 16S rRNA. Degradation of 16S rRNA leads to 23S rRNA degradation. Processes the 3 tRNA(Pro) precursors immediately after the 3'-CCA to generate the mature ends.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11134527}. Cell inner membrane {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}; Peripheral membrane protein {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}; Cytoplasmic side {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}. Note=Associated with the cytoplasmic membrane via the N- and C-terminal regions. {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase
- Enolase
- ATP-dependent RNA helicase RhlB
- RNA-binding protein Hfq
- Ribonuclease R
- Transcription termination factor Rho
- ATP-dependent RNA helicase SrmB
- Regulator of ribonuclease activity A
- Ribonuclease P protein component
- Poly
Sequence:
MKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPANYSAHGRPNIKDVLREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDDRTELKEALASLELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLSYMLPKLHEEAMALPSEEEFAERKRPEQPALATFAMPDVPPAPTPAEPAAPVVAPAPKAAPATPAAPAQPGLLSRFFGALKALFSGGEETKPTEQPAPKAEAKPERQQDRRKPRQNNRRDRNERRDTRSERTEGSDNREENRRNRRQAQQQTAETRESRQQAEVTEKARTADEQQAPRRERSRRRNDDKRQAQQEAKALNVEEQSVQETEQEERVRPVQPRRKQRQLNQKVRYEQSVAEEAVVAPVVEETVAAEPIVQEAPAPRTELVKVPLPVVAQTAPEQQEENNADNRDNGGMPRRSRRSPRHLRVSGQRRRRYRDERYPTQSPMPLTVACASPELASGKVWIRYPIVRPQDVQVEEQREQEEVHVQPMVTEVPVAAAIEPVVSAPVVEEVAGVVEAPVQVAEPQPEVVETTHPEVIAAAVTEQPQVITESDVAVAQEVAEQAEPVVEPQEETADIEEVVETAEVVVAEPEVVAQPAAPVVAEVAAEVETVAAVEPEVTVEHNHATAPMTRAPAPEYVPEAPRHSDWQRPTFAFEGKGAAGGHTATHHASAAPARPQPVE
Protein: ADP-ribosylation factor 2-A (AtARF2) (Q9LQC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular location: Golgi apparatus.
Interaction partners:
- Auxin response factor 2
- Kinesin-like protein KIN-14E
- Auxin response factor 7
- Auxin response factor 1
- Auxin transporter protein 1
- Auxin response factor 5
- Auxin response factor 6
- Auxin response factor 12
- Auxin response factor 8
- Auxin response factor 22
Sequence:
MGLSFAKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIAGKA
Protein: Periodic tryptophan protein 2, putative (Q388S0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- CCAAT-binding factor domain-containing protein
- Nop14-like protein
- Uncharacterized protein
- Bystin, putative
- DDB1- and CUL4-associated factor 13
- Nrap protein domain-containing protein
- PNO1 second type I KH domain-containing protein
- Sas10 C-terminal domain-containing protein
- Uncharacterized protein
- RNA cytidine acetyltransferase
Sequence:
METNFQLASVHGMLYTGGNVAFSPDGRQLYSPVNNYISSIKLQQEGHHSLPCSNSNIQCFDISSDGDLIVAIGRRGVGFFYSLSAAVVLDTISFPPDCEVSCVKFSPCGRYVALALDTTLQVYTAPAQRIVSYHGCHRVENLHNALTLPIMCIEWTPDSEHILLSGQDARMKICPRQCRVQQKGMALQHNALVGHRAAVCGAWFVDSACNRVVSVSVDNVVMTWKQTRTTRQEVMRAIASAKLNARVGAQSEEDEYTHAEDDEGAAIPKSFLEKQRLEQLKIEGVRVSVADDTFLPDILRYAFEVDKKHMLTHKGNVSVTAFHRPRGLLAIGYNSGIFAIHSLGGSGEAEFPLVHLLSISAQSLTAAAFNASGDFIAFGSAHLKQILVWDWKSEAYVLKEQSHYYDINRTAITADASSIISGGDDGKVKVWRASTGQCYVTFTEHTAPVTGIATSAATNAFFTCSRDGTARGYDLVRYRHFRVYSAPEQAQLSCVAVDPSGEVLAVGSGQTDRIYLFAVQTGKLIDQLQGHEAPIACVAFHPSGTALVSGSLDHNLAVWDLFAHGDGGDRLKGTVEVTNVGSEVLSLSFSNSGRYLAVLTMKQEVTVYETLVPTEPIVIKTFQTSFDAAGGWCKSVGPRSANYNARFTTIAFSPEGEKIVAGGDSKWIVLYHAKQGYMLKKWPITTNLDVQGAEEQYQWRQMTEAGHIDDIDVDDTDIHLRRGKLLEMPGSKHRHFATGKRQTALSARTMSVAFASTGTEFVAATSVGLLVFSTHVARPRFQPLQLTANITTQQVRDQLARGESVMALIGALNLGDRMLGIECMRRMPQSAIPVAVSSVPSVLFSLLLKWVSSEVEESRGLERALLWAQSILLHSSECAGSFSCDRSLIIPPLKVLQRSLQRHRALGDLARENYFSLQYIIDMTKMQRDVLKPAAEVTE
Protein: Proton channel OTOP3 (Otopetrin-3) (Q80UF9)
Organism: Mus musculus (Mouse)
Function: Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:37023615}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A9JTM7}.
Interaction partners:
Sequence:
MASQTSAPAEPAPMPSPEAKTTEGASSYDQADMETKHAGSPCPPKQKSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVSVTLGDVWILLAALKVLSLLWLLYYTVGTTRKPHAVLYRDPHAGPIWVRGSLVLFGSCTVCLNIFRMGYDVSHIHCKSEVELIFPAIEIVFMIIQTWVLWRHCKDCVQVQTNFTRCGLMLTLATNLLMWVLAVTNDSMHREIEAELDALMEKFSGNGTNTCMCLNTTVCEVFRKGYLMLYPFSTEYCLICCAVLFVMWKNVSRSLAAHTGAHPNRSPFRLHGTIFGPLLGLLALVAGVCVFVLFQIEASGPDIARQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTLKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVATQPHELLNQLILAYSLLLILQHITQNLFIIEGLHRRPLWEPAVSGVMEKQDVELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRMLKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTIVNFGLPLGVFYRMHSVGGLVEVYLGA
Protein: AT03545p (Wampa) (Q9VCN4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Armadillo repeat-containing protein gudu
- Dynein axonemal assembly factor 4
- Uncharacterized protein
- Protein kintoun
- Uncharacterized protein, isoform C
- Lethal
- Dynein axonemal assembly factor 1 homolog
- GH13165p
- FI13205p
- Dynein axonemal intermediate chain 4
Sequence:
MEEIKKFDKLAFLESYLLKHKELGKRQREYKKILSSKLKTRKETIIEASFETAIDQLEEEKNDLRAQIWVASGTTHKKQNNRWLELIRCHVECQENLSQDINSLKTSISNMEKEISRMSKQIYNLNRLTIPDQQHQAYVMRARKRMTILENSLEVGVRQECGFTAANADLREQLIRILNHRTFFNDSYTKMVQKLNSEKKYLIDLIEYALNTFDGCIEVYEKIDLLAKREAKERDMRRVEMQGIMRKVAADGDNTAFLNCKSKPRELADLQPKEYKRRDEFRRVHNKKINLYNSVLQKILQYTESSNMDEVIDKFQQQESLYYSFFNYANEMSYHITMLNNSVNRLFEDIVNLKKDNSNTLQDQLDQISSLENKVRNKQESNMELHKARENNDARLENLLQGVETVCEMCSIDASPLTKLLGDHTHVNLVNVNRFLKLLETRVQELTASVYVMERQEEGRFDYVVKQIEKICELPTDLNDIVLTQQCPECAEGEAFNMDEGGDGVLVHTVAEAKKKLYEKVTQPEMQYRLHSISQCRLPRSRLLAAKRNM
Protein: Uncharacterized protein (Q5A785)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- NADH dehydrogenase iron-sulfur protein 4
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Fgr39p
- Uncharacterized protein
- NADH dehydrogenase 1 alpha subcomplex subunit MCI4
Sequence:
MLSGVRQQSKLFTKSISQVSKRYNSSHNHHHHEPESKPLEITFAKIFGVAAIAGGLLVYKNKDKTDKPLFSSKFFDEITTGERSHLRDEQYERKYKIGYLRTFDRDNGGIGQQLNKVSAYELPNNNLIPAHSPFGNQFGVGIKTNELGPRRERAQRFAPLQQPAEN
Protein: Transcription factor PCF1 (Proliferating cell factor 1) (O23875)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription activator. Binds the promoter core sequence 5'-GGNCC-3', especially at sites IIa (5'-GGGCCCAC-3') and IIb (5'-GGTCCCAC-3') (essential for meristematic tissue-specificity expression) of the PCNA gene promoter. Can target the TCP motif 5'-TGGGCC/T-3'.
Subcellular location: Nucleus {ECO:0000269|PubMed:24170127}.
Interaction partners:
- Two-component response regulator-like PRR1
Sequence:
MMASSDLILYNLVPAQPLNPSAIPNPNPDLSIAAAEPPSSDGATPRRVRPRKSPSSSDRHSKVAGRGRRVRIPAMVAARVFQLTRELGHRTDGETIEWLLRQAEPSIIAATGTGVTPEEAPPAAVAIGSSSVAAAAAAGGHGGAFVHVPYYTALLMQPPNADEPPMASAASASGTTAADENNN
Protein: Transmembrane 9 superfamily member 10 (Endomembrane protein 3) (Transmembrane nine protein 10) (AtTMN10) (Q8RWW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:P32802}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAKVRILIFTLVLFFSLNVHIHGFYLPGVAPQDFQMGDALMVKVNKLTSTKTQLPYSYYSLPYCRPEHIVDSAENLGEVLRGDRIENSPFVFKMRESQMCAAVCRVKLDKKTAKAFKEKIADEYRVNMILDNLPLVVPVQRPDQDNVVVYQHGFHVGLKGIFAGKKEEKYFIHNHLTFTVRYHRDIQTDSSRIVGFEVKPFSVKHEYEGQWNEKARLTTCDPHTKRAVTNSESPQEVEEGNEIIFTYDVDFQESEVKWASRWDTYLLMADDQIHWFSIVNSMMIVLFLSGMVAMIMLRTLYRDISNYNQLESHEEALEETGWKLVHGDVFRPPTNPELLCVYAGTGVQCFGMILVTMIFACLGFLSPSNRGGLMTAMLLLWVFMGLLAGYASSRLYKTLRGTEWKRNALKTAFMFPATVFVAFFVLNAIIWGQKSSGAVPFGTMFALVVLWFGISVPLVFIGGYIGFRKPAPEDPVKTNKIPRQIPTQAWYMNPIFSILIGGILPFGAVFIELFFILTSIWLHQFYYIFGFLFIVFIILIITCAEITVVLCYFQLCSEDYQWWWRSYLTSGSSAVYLFLYAVFYFYTKLEITKLVSAVLYFGYMLIVSYVFFVFTGAIGFYACFWFTRLIYSSVKID
Protein: Transmembrane protease serine 11F (EC 3.4.21.-) (Airway trypsin-like protease 4) (Q8BHM9)
Organism: Mus musculus (Mouse)
Function: Probable serine protease.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Transmembrane protease serine 4
Sequence:
MMYAPVEFSQTAYPRIEYQRRQQQFWDPIRLALFTLAIVAIVGITIGIVTHFVVEDDKSFYYLASFQVTSIKYRENYGIRSSREFIERSHQIERMMSRIFRRSSGVGRFIKSHVIKISPDEQGVNILIVLMFRYPSTDSAERIKKRIERTFYQSLKIKQLPLTISMPSFSLTPIDSKKMRNLLNSRCGIRMSSSNIPLPASSSTERIVQGRETAMEGEWPWQASLQLIGAGHQCGATLISNTWLLTAAHCFWKNRDPTKWIVTFGTTITPPLVKRSVGKIIIHEEYHRDTNENDIALAQLTTRVEFSNVVQRVCLPDSSMKLPPKTSVFVTGFGSIVDDGPTQNKLRQARVETIGSDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNRDIWYIVGIVSWGQSCALPNKPGVYTRVTKYRDWIASKTGL
Protein: Protein-arginine deiminase type-4 (EC 3.5.3.15) (PAD-R4) (Peptidylarginine deiminase IV) (Peptidylarginine deiminase type alpha) (Protein-arginine deiminase type IV) (O88807)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (By similarity). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UM07}. Nucleus {ECO:0000250|UniProtKB:Q9UM07}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9UM07}. Note=Cytoplasmic granules of eosinophils and neutrophils. {ECO:0000250|UniProtKB:Q9UM07}.
Interaction partners:
- Histone H3
- Histone H3.1
- Myeloperoxidase
Sequence:
MAQGAVIHVAPEEPTHAVCVVGTATPLDIRGSAPRGSTSFSITASPEVVVDVIHGPPSKKSTTGASKWPLDPKLEVTLQMKAASSRIDDQKVRISYYGPKTSSTQALLYLTGVELSLSADVTRTGKAKPAPAGKDQSTWTWGPDGHGAILLVNCDKEDPKSSGMDFEDDKVLDNKDLQDMSPMTLSTKTPKDFFDKYQLVLQVPKAKMNKVRVFRATRGKLPSRYKVVLGPQQFSHRLELLGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDTVMFRVAPWIMTPNTQPPQEVYVCRFSDNEDFLKSLATFTKKAKCKLTVCPEEENQDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRGLYRAEVTGLDAFGNLEVSPPVTVRGKEYPLGRILIGSSGYSSSESRDMHQILQDFLGAQQVQAPVRLFSDWLFVGHVDEFLSFVPARGKQGFRLLLSSPRACYQMFQELQTEGHGEASLFEGLKRKRQTISDILSSQKLRDQNAYVESCIDWNREVLKRELGLTEGDIIDIPQLFRIVGNSRGNPKAEAFFPNMVNMLVLGKHLGIPKPFGPIINGRCCLEEKVCSLLEPLGLHCTFINDFYSYHMYHGEVHCGTNVRRKPFAFKWWHMVP
Protein: Cyclic di-GMP phosphodiesterase RocR (c-di-GMP PDE) (EC 3.1.4.52) (Response regulator RocR) (Q9HX69)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Diguanylate cyclase TpbB
- histidine kinase
- Diguanylate cyclase
- GGDEF domain-containing protein
- diguanylate cyclase
- diguanylate cyclase
- Diguanylate cyclase
- diguanylate cyclase
- Two-component response regulator RocA1
- diguanylate cyclase
Sequence:
MNDLNVLVLEDEPFQRLVAVTALKKVVPGSILEAADGKEAVAILESCGHVDIAICDLQMSGMDGLAFLRHASLSGKVHSVILSSEVDPILRQATISMIECLGLNFLGDLGKPFSLERITALLTRYNARRQDLPRQIEVAELPSVADVVRGLDNGEFEAYYQPKVALDGGGLIGAEVLARWNHPHLGVLPPSHFLYVMETYNLVDKLFWQLFSQGLATRRKLAQLGQPINLAFNVHPSQLGSRALAENISALLTEFHLPPSSVMFEITETGLISAPASSLENLVRLRIMGCGLAMDDFGAGYSSLDRLCEFPFSQIKLDRTFVQKMKTQPRSCAVISSVVALAQALGISLVVEGVESDEQRVRLIELGCSIAQGYLFARPMPEQHFLDYCSGS
Protein: 10 kDa chaperonin (Q8I5Q3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock protein 60
- 60 kDa chaperonin
- GrpE protein homolog
- Endoplasmic reticulum chaperone GRP170
- Heat shock protein 70
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit eta
- CCT-beta
Sequence:
MSSTITRKFIPLMDRILISKIVPKTTTKSGLFLPESATEPSYTGKVLAVGPGRVTSNGTKISPSVKEGDVVVLPEYGGSSLKIDGEEFFVYRDDDIIGIIKDE
Protein: Bridging integrator 1 (Q9BTH3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLRAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVP
Protein: Nuclear receptor subfamily 4 group A member 2 (F1D8N6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
Protein: Uncharacterized protein (Q57Z33)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNSSLVFDKDGNECSVGDVVDEIIDKLSLYRSCGGDGSSVVLRKKNRNVAHDSLVNSVKRGVNPFYVNVRSSARFRRRKRCKYIVPSNVSAKSSVEPKNSLFSCKVGNVLPVMSHGASVVAPGRAITGRKVFAACRGITKAVLLFKLFKAESLPGGSKRVRCYRKRMLKKEASVLGSFDHSAASAGLDTLFWGAVASVVRYRDLYKRRLCVIWNDKLNSGEKIPHPLLLLRSLPLFGLVVEVQKLWWRCRDAECGCSPEVVESSMGIVLHESGGFIGVALLGSLESLRIGLENLRKNPEQPISGREEPRSEECGVTHFSSFCSTFPAARVIQVAKVCASGLGPAVPAAVRKPQSGELVVARVAADEVTAPDCPFKELIGRFL
Protein: Iodothyronine deiodinase (Q802F6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGSAVGFALRKLFVYISAVLMVCAAILQMSMLKLLSFISPGRMRKIHMKMGERSTMTQNPKFRYEDWGPAFFSLAFIKTLFFVNWCSLGLEAFEGHAAPDSALITLDRQKTSVHRFLKGNRPLVLSFGSCTUPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHATDAWAFKNNVDISVHKNLEERLAAARTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIYQASDLGGQA