wanglab/gogpt-training-data huggingface dataset:
Protein: AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) (Q9BVN2)
Organism: Homo sapiens (Human)
Function: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15024033}. Nucleus {ECO:0000269|PubMed:15024033}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BG26}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8BG26}. Early endosome {ECO:0000250|UniProtKB:Q8BG26}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BG26}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BG26}. Note=Translocated to the nuclear envelope upon stimulation with NGF (PubMed:15024033). Associated with membranes and microtubules (By similarity). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033}.
Interaction partners:
- RUN domain-containing protein 3A
- Diphosphomevalonate decarboxylase
- Squalene synthase
- Lanosterol synthase
Sequence:
MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELQEGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQEEEGAASPSDPGCSSSLSSCSDLSPDESPVSVYLRDLPGDEDAHPQPSIIPLEQGSPLASAGPGTCSPDSFCCSPDSCSGASSSPDPGLDSNCNALTTCQDVPSPGLEEEDERAEQDLPTSELLEADDGKIDAGKTEPSWKINPIWKIDTEKTKAEWKTTENNNTGWKNNGNVNSSWKSEPEKFDSGWKTNTRITDSGSKTDAGKIDGGWRSDVSEEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPSGSPGGSSAPPREVTTFKELRSRSRAPAPPVPPRDPPVGWALVPPRPPPPPVPPRRKKNRPGLQPIAEGQSEEGRAVSPAAGEEAPAAKEPGAQAGLEVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL
Protein: L-fucose mutarotase (EC 5.1.3.29) (D-ribose pyranase) (EC 5.4.99.62) (Fucose 1-epimerase) (Type-2 mutarotase) (P0AEN8)
Organism: Escherichia coli (strain K12)
Function: Involved in the anomeric conversion of L-fucose. Catalyzes also the interconversion of beta-pyran and beta-furan forms of D-ribose.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- L-fucose isomerase
- L-fuculokinase
- L-fuculose phosphate aldolase
- L-fucose-proton symporter
- Probable hydrolase YcaC
Sequence:
MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
Protein: G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) (P63250)
Organism: Mus musculus (Mouse)
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G protein-activated inward rectifier potassium channel 2
- G protein-activated inward rectifier potassium channel 4
- G protein-activated inward rectifier potassium channel 3
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid type B receptor subunit 1
- Guanine nucleotide-binding protein G
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGPTRMEGNLPAKLRKMNSDRFT
Protein: Septin 9 (K7ENL0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSMSAGTINTLKRSFEVEEVETPNSTPPRRVQTPLLRATVASSTQKFQDLGVKNSEPSARHVDSLSQRSPKASLRRVELSGPKAAEPVSRRTELSIDISSKQVENAGAIGPSRFGLKRAEVLGHKTPEPAPRRTEITIVKPQESAHRRMEP
Protein: Protein NDNF (Neuron-derived neurotrophic-like factor) (Protein Nord) (Q9W192)
Organism: Drosophila melanogaster (Fruit fly)
Function: Secretory protein that acts as a feedback regulator of dpp/BMP, wg and hh signaling pathways. In the developing wing, is a dosage-dependent modulator of dpp/BMP signaling involved in wing growth and crossvein patterning; low levels promote and high levels inhibit dpp/BMP signaling. In the early pupal wing, inhibits dpp/BMP signaling activity to prevent the formation of ectopic crossveins in the posterior compartment. Binds to dpp and gbb to modulate their release and activity decreasing dpp/BMP signaling in the responding cells. During wing development regulates dpp/BMP coreceptor dally availability on the cell surface. Might have a role in testis development.
Subcellular location: Secreted {ECO:0000269|PubMed:35037619, ECO:0000269|PubMed:35609633}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:35037619}.
Interaction partners:
Sequence:
MQRSTMLPGVELLLLFLLSTSLHAEISHLPMASNRIILDSTELLQNPLIQDAGVPAARATPLPPQKCPSLQRYRKMLKDFDDLEDLYVDVPVHIALAERQRKRFVLNLNDSTPLTIRFSAPVGRKMYYNQTGNPLRPAAVAPGPGVAVGSLVLPCALRGQYDLFVLARHSGALKVDALAEHPQHDWPLLNATHRIAIRTQNRVRKREMIVKWERSKFDFHVMHYCLVIQRLSMDTPRMIFTNFCQAVSAYTDQQPMTPSCAAGGPLEGIWGAPPQRERRLNPRQNVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIHQGRQNLTLRLASSQVNFNRTQPLALKQQALMQLKIGGQHGKQVYSFKVPQTTRQLGEPFMRHLLIPCSGSEIRVKLLRQRSEVGKTEAFYSPTYIRQKGVLPGERYLMRFEPSNDDEALRAQKVMVALSSEALFRDLPELPQNTTVFNVRTRCSRATIAWNGSPDERELSYCIIVFNLPQRNRSVVDFTNYCMDFVPKRVMQYRYFEWMTCRERQQSPDNIETETILNLMPGSSYLVYVTANLSMGKPLPYQALTLHMASQCLDGSHESFY
Protein: Proteasome 20S subunit beta 10 (A0A8L2UK72)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLKQAVEHRGGFSFENCQRAGGLEGQPLRRSVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLNGPQLYSVHPHGSYSRLPFTALGSGQDAAVALLEDRFQPNMTLEAAQELLVEAITAGILGDLGSGGSVDACVITAGGAKLQRALSSPIEPVQRAGQYRFAPGTTPVQTQEVRALTLELLEETVQAMEVE
Protein: Mitochondrial import inner membrane translocase subunit TIM44 (Q9VDZ7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|PIRNR:PIRNR037871}.
Interaction partners:
- SD19278p
- Heat shock 70 kDa protein cognate 5
- GrpE protein homolog, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim16
- Mitochondrial import inner membrane translocase subunit Tim16
- GH27195p
- Mitochondrial import inner membrane translocase subunit TIM14
- GEO10507p1
- Mitochondrial import inner membrane translocase subunit Tim21
- Probable mitochondrial import inner membrane translocase subunit Tim17 4
Sequence:
MKATSCRPIPFINFRIVRYFYRPRRLNKYYDIYRIAALVRDRACLFTCQQASQNLQQQQPRFYSAPGRRAGFFSQFFDNMKAEMDKNKEIKDNIRKFREEAQKLEESDALKSARQKFNIVESEAQKSSSMLKEQLGAIKERVGDVLEDASKSHLAKKVTEELSKKARGVSDTISDTSGKLGQTSAFQAISNTTTTIKKEMDSASIENRVYRAPAKLRKRVQLVMSDSDRVVEPNTEATGMELHKDSKFYESWENFKNNNTYVNKVLDWKVKYDESENPVIRASRLLTDKVSDVMGGLFSKTELSETMTELVKIDPSFDQKDFLRDCETDIIPNILESIVRGDLEILKDWCFESTFNIIANPIKEAKKAGVYLDSKILDIENIELAMGKVMEQGPVLIITFQAQQIMCVRDQKSQVVEGDPEKVMRVHYVWVLCRDRNELNPKAAWRLMELSANSSEQFV
Protein: E3 ubiquitin-protein ligase SlrP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SlrP) (Secreted effector protein SlrP) (D0ZRB2)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death.
Subcellular location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 T3SS), and delivered into the host cytoplasm.
Interaction partners:
Sequence:
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAYADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSEITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEEDVNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAMNATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGITESDLDEAEIRIKMAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTTEVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR
Protein: Transcription repressor OFP16 (Ovate family protein 16) (AtOFP16) (Q9SKY9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription repressor OFP18
- Transcription repressor OFP5
- Transcription repressor OFP2
- Transcription repressor OFP7
- Transcription repressor OFP6
- Transcription repressor OFP8
- Transcription repressor OFP1
- Transcription repressor OFP17
- Transcription repressor OFP3
- Transcription repressor OFP4
Sequence:
MPKILWKSLHLCFPSNLTKCYSSPCIPPSSADPDGIIQPNRPSIVLLNNFNLLYHNDNHHHPHRVIDLPSSSTTTTPAATSSSSTSSYESDISPDVSAAFASRRFFFSSPGRSNAITDSPEPRSREFSDNYDDATITSTKKKKKKVYDNSVTTTTTRLISGGTAVTQHVDSPDPLTDFRRSMQEMIDAAIDAGELSRDPNDGYDFLDELLLTYLSLNPADTHKFVIRAFSDILVSLLSEERRIC
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q7T2F2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Heat shock protein beta-1
- MAPK-activated protein kinase 3
- mRNA decay activator protein ZFP36
- mRNA decay activator protein ZFP36
- mRNA decay activator protein ZFP36
- mRNA decay activator protein ZFP36
- mRNA decay activator protein ZFP36
- Cyclic AMP-dependent transcription factor ATF-4
- non-specific serine/threonine protein kinase
- Cyclic AMP-dependent transcription factor ATF-4
Sequence:
MLTNANSPPKFPNQQQQQQQQNPPQFMLGKGSLQIKKNAITDDYKITNQVLGLGINGRVLEIFYKRSGEKLALKMLHDCPKARREVELHWRASSCTHIVKIVDVYENLYQNRKCLLIVMECMDGGELFSRIQDRGDQAFTEREASDIMKSIGEAIQYLHAINIAHRDVKPENLLYTSKRPNALLKLTDFGFAKETTTHNSLATPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKKRIRMGQYEFPNPEWSEVSEEAKQLIRTLLKTEPTQRMTITEFMNHPWINQSMEVPQTPLHTSRVLKEEKDTWEDVKEEMTSALATMRVDYEQIKIKRIEDSTNPLLIKRRKKTTVAPENETPAC
Protein: Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) (P29120)
Organism: Homo sapiens (Human)
Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Subcellular location: Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Interaction partners:
- Pro-opiomelanocortin
- Insulin
- Pro-glucagon
- Carboxypeptidase E
- Receptor-interacting serine/threonine-protein kinase 3
- Receptor-interacting serine/threonine-protein kinase 1
- Melanocortin receptor 4
- Mixed lineage kinase domain-like protein
- ProSAAS
- Appetite-regulating hormone
Sequence:
MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
Protein: Homeobox protein Hox-D13 (Homeobox protein Hox-4.8) (P70217)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).
Subcellular location: Nucleus {ECO:0000305|PubMed:15489334}.
Interaction partners:
- Sonic hedgehog protein
- Nuclear pore complex protein Nup98-Nup96
- Homeobox protein Meis1
Sequence:
MSRSGTWDMDGLRADGGAAGAAPASSSSSVAAPGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASSFAYPGTSERTGSSSSSSSSAVIATRPEAPVAKECPAPAAAATAAAPPGAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPTNEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCAKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS
Protein: Novel plant SNARE 13 (AtNPSN13) (Q9LRP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vesicle trafficking protein that functions in the secretory pathway.
Subcellular location: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Syntaxin-73
- Syntaxin-72
- Syntaxin-71
- Syntaxin-112
- Syntaxin-related protein KNOLLE
- Syntaxin-132
- Syntaxin-52
- Vesicle transport v-SNARE 13
- Golgi SNAP receptor complex member 1-1
- Golgi SNAP receptor complex member 1-2
Sequence:
MASNLPMSPQLEQIHGEIRDHFRALANGFQRLDKIKDSTRQSKQLEELTDKMRECKRLVKEFDRELKDEEARNSPEVNKQLNDEKQSMIKELNSYVALRKTYMSTLGNKKVELFDMGAGVSGEPTAEENVQVASSMSNQELVDAGMKRMDETDQAIERSKQVVEQTLEVGTQTAANLKGQTDQMGRVVNHLDTIQFSIKKASQLVKEIGRQVATDKCIMGFLFLIVCGVVAIIIVKIVNPNNKDIRDIPGLAPPAQSRKLLYLRNQDYM
Protein: UPF0593 mitochondrial protein C806.05 (Q9UT54)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MKKEHASAFRQLWRAGMAAAISTRFPGHRFVIRDLLRNGFRQNNCSFYSKEKVENTVIFLEMAASRKSVEHLILKNRLHIQMFRRKAGQRLAHYSTAKERPYFLSAYDTYEWCLQRVGTIYNLYL
Protein: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (MoaD protein adenylase) (Molybdopterin-converting factor subunit 1 adenylase) (Sulfur carrier protein MoaD adenylyltransferase) (P12282)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD.
Interaction partners:
- Molybdopterin synthase sulfur carrier subunit
- Molybdopterin molybdenumtransferase
- Molybdopterin synthase catalytic subunit
- Cysteine desulfurase IscS
- Cyclic pyranopterin monophosphate synthase
- GTP 3',8-cyclase
- Molybdenum cofactor biosynthesis protein B
- tRNA sulfurtransferase
- Thiazole synthase
- 3-mercaptopyruvate sulfurtransferase
Sequence:
MAELSDQEMLRYNRQIILRGFDFDGQEALKDSRVLIVGLGGLGCAASQYLASAGVGNLTLLDFDTVSLSNLQRQTLHSDATVGQPKVESARDALTRINPHIAITPVNALLDDAELAALIAEHDLVLDCTDNVAVRNQLNAGCFAAKVPLVSGAAIRMEGQITVFTYQDGEPCYRCLSRLFGENALTCVEAGVMAPLIGVIGSLQAMEAIKMLAGYGKPASGKIVMYDAMTCQFREMKLMRNPGCEVCGQ
Protein: Cyclic nucleotide-gated channel beta subunit (O35788)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLGWVQRVLPQPPGTPQKTEEGAGPQPETESKPEANPQPEPEVQPEPEPEPEPEPEPEPAPEEAAPEVQTLPPEEPVEGEDVAEAGPSLQETQEADPPQPTSQAQVAVVKVNRPSSWMLSWFWKGMEKVVPQPVYSSSGGQNLAAGEGGPDQDGAQTLEPCGTGDPGSEDGSDKTSKTQDTEPSLWLLRWLELNLEKVLPQPPTPSQAWKVEPEGAVLEPDPPGTPMEVEPTENPSQPNPGPVEPEEEPAAEPQPGFQASSLPPPGDPVRLIEWLLHRLEMALPQPVLHGKAAEQEPSCPGTCDVQTISILPVEQAEHDLVLEDVDSCWEDTQQEDGASLQETELAPIYEDESEAMVEMPRELPQIQEQQEEENEEKEEEEEEKEEKEEKEEEEEKEEEEKREEEKKKEKEEEKKEKEEEENGEEEEKEEKEEKEEEEGKEEKEEKEEKEEKEEEEKEEKEEEEKEEKEEEEEEEEEEEEEEPIVLLDSCLVVQADVDQCQLERAQPETASIQELPEEEEEKEEEKKEEEEEKEEEEEKEEEEEKEEEGEATNSTVPATKEHPELQVEDTDAEAGPLIPEETIPPPERPPVSPAKSDTLAVPSAATHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGEDRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPDSAPAQKPAEAEAAEEEHYCDMLCCKFKRRPWKMYQFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHLWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNNYLKSQRFKMDLLCLLPLDFLYLKLGVNPLLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQGIGSTHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKLFNAALAAAGKMGPRGAKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGSGATDQPAPQEPSEPKEPPEPPAPSSPPPASAKPEGSTEEAAGPPEPSVRIRVSPGPDPGEQTLSVEMLEEKKEEVE
Protein: Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A) (Q86V40)
Organism: Homo sapiens (Human)
Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.
Interaction partners:
Sequence:
MSPWSWFLLQTLCLLPTGAASRRGAPGTANCELKPQQSELNSFLWTIKRDPPSYFFGTIHVPYTRVWDFIPDNSKEAFLQSSIVYFELDLTDPYTISALTSCQMLPQGENLQDVLPRDIYCRLKRHLEYVKLMMPLWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDIKSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVIFALNQTLLQQESLRAGSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPNFINATLPPQERITAQEIDSYLRRELIYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGRPIHKGKSKKTSTRPTLSTIFAPKVPTLEVPAPEAVSSGHSTLPPLVSRPGSADTPSEAEQRFRKKRRRSQRRPRLRQFSDLWVRLEESDIVPQLQVPVLDRHISTELRLPRRGHSHHSQMVASSACLSLWTPVFWVLVLAFQTETPLL
Protein: Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] (Q8I2N0)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03208}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03208}. Note=Equally found in the membrane-bound as well as in the soluble fraction. {ECO:0000256|HAMAP-Rule:MF_03208}.
Interaction partners:
- Phosphatidylserine synthase, putative
- Choline/ethanolaminephosphotransferase, putative
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Mitochondrial cardiolipin synthase, putative
- Bifunctional dihydrofolate reductase-thymidylate synthase
Sequence:
MRKGKSPSSFFSLHKKYLLTGVTILSFIFMFQYKYHEVLTVYEDKTNVQQSSRLFWTRLLFGRTRSRITGRIFNIEIPHSYRLYVYNFFIKYLNINKEEIKYPIESYKSLGDFFSRYIREDTRPIGDLNEYSIVSPCDSEIVDFGELTSNYLDNVKGIKFNIKTFLGSDMIKKYNDDSTSFYYAIFYLSPKKYHHFHAPFNFKYKIRRHISGEVFPVFQGMFKIINNLFDINERVILSGEWKGGHVYYAAISAYNVGNIKIVNDEDLLTNNLRTQLSYMGGDINTKIYDHYKDLEIGDEVGEFKVGSSIIVIFENKKNFKWNVKPNQQISVGERIGGVDQPKQPKNKFIKIRS
Protein: Telomere repeat-binding factor 2 (AtTRB2) (MYB transcription factor) (Telomere-binding protein 3) (AtTBP3) (Q9FJW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:19947985}. Nucleus, nucleolus {ECO:0000269|PubMed:19947985}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:19947985}. Note=Localized to the nucleolus during interphase.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL13x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS1y
Sequence:
MGAPKQKWTPEEEAALKAGVLKHGTGKWRTILSDTEFSLILKSRSNVDLKDKWRNISVTALWGSRKKAKLALKRTPPGTKQDDNNTALTIVALTNDDERAKPTSPGGSGGGSPRTCASKRSITSLDKIIFEAITNLRELRGSDRTSIFLYIEENFKTPPNMKRHVAVRLKHLSSNGTLVKIKHKYRFSSNFIPAGARQKAPQLFLEGNNKKDPTKPEENGANSLTKFRVDGELYMIKGMTAQEAAEAAARAVAEAEFAITEAEQAAKEAERAEAEAEAAQIFAKAAMKALKFRIRNHPW
Protein: Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain) (P69892)
Organism: Homo sapiens (Human)
Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Interaction partners:
- Hemoglobin subunit gamma 1
- Hemoglobin subunit alpha
- HBS1-like protein
- Hemoglobin subunit mu
- Mitochondrial intermediate peptidase
- Alpha-hemoglobin-stabilizing protein
- Hemoglobin subunit theta-1
- Hemoglobin subunit delta
- Hemoglobin subunit zeta
- BCL11 transcription factor A
Sequence:
MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH
Protein: Nuclear receptor-binding protein homolog (MLF1-adaptor molecule) (Q9Y0Y6)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus.
Subcellular location: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9UHY1}.
Interaction partners:
- Protein bunched, class 2/F/G isoform
Sequence:
MSNSQANAGISGSTVADEPIQHHPSLAAGPVSASCPAATPPSQSTQQPPPHIVSASTADAGSSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLLEETLKAGVMSDGAGAESSGAGVTTTATMAALEQLERNWSISSDADKQGTAVMYVPQEQQNADGDVDVEHSGTTSN
Protein: Protein EURL homolog (Q9NYK6)
Organism: Homo sapiens (Human)
Function: Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.
Interaction partners:
Sequence:
MNEEEQFVNIDLNDDNICSVCKLGTDKETLSFCHICFELNIEGVPKSDLLHTKSLRGHKDCFEKYHLIANQGCPRSKLSKSTYEEVKTILSKKINWIVQYAQNKDLDSDSECSKNPQHHLFNFRHKPEEKLLPQFDSQVPKYSAKWIDGSAGGISNCTQRILEQRENTDFGLSMLQDSGATLCRNSVLWPHSHNQAQKKEETISSPEANVQTQHPHYSREELNSMTLGEVEQLNAKLLQQIQEVFEELTHQVQEKDSLASQLHVRHVAIEQLLKNCSKLPCLQVGRTGMKSHLPINN