wanglab/gogpt-training-data huggingface dataset:
Protein: Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5) (O55234)
Organism: Mus musculus (Mouse)
Function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P28074}. Nucleus {ECO:0000250|UniProtKB:P28074}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P28074}.
Interaction partners:
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-4
- Proteasome subunit beta type-4
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-2
Sequence:
MALASVLQRPMPVNQHGFFGLGGGADLLDLGPGSPGDGLSLAAPSWGVPEEPRIEMLHGTTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSSVSVP
Protein: Protein tyrosine kinase 2 (H0YB16)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
IAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
Protein: Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1) (Q9Y272)
Organism: Homo sapiens (Human)
Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
- Nitric oxide synthase 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Calmodulin-1
- Calmodulin-like protein 6
- Calmodulin-like protein 4
Sequence:
MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLRQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVDQREIEQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGGDPGDAFGIVAPFARRPSVHSDLMYIREKASAGSQAKDKERCVIS
Protein: Pentatricopeptide repeat-containing protein At3g60980, mitochondrial (Q9LEX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
Sequence:
MSLIGRLNLGRRFCTAVPRRSEDIMSNPDCRPSDLCLRVSYLIRCVGDLDTAAKYARLAVFTSIKSESTTTICQSIIGGMLRDKRLKDAYDLYEFFFNQHNLRPNSHCWNYIIESGFQQGLVNDALHFHHRCINSGQVHDYPSDDSFRILTKGLVHSGRLDQAEAFLRGRTVNRTTYPDHVAYNNLIRGFLDLGNFKKANLVLGEFKRLFLIALSETKDDLHHSNYENRVAFLMATFMEYWFKQGKQVEAMECYNRCVLSNRLLVCAETGNALLKVLLKYGEKKNAWALYHELLDKNGTGKGCLDSDTIKIMVDECFDMGWFSEAMETYKKARPKNDYLSDKYIITRFCENRMLSEAESVFVDSLADDFGYIDVNTYKTMIDAYVKAGRIHDAIKTSNKMIDATLKEVSHLF
Protein: DNA-directed RNA polymerases II and V subunit 6B (Q9SJ96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerase V which mediates RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase I subunit 2
- DNA-directed RNA polymerase II subunit 4
- DNA-directed RNA polymerases II and IV subunit 5A
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases II, IV and V subunit 9A
- DNA-directed RNA polymerases IV and V subunit 3B
- DNA-directed RNA polymerase II subunit 7
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases II, IV and V subunit 8B
- DNA-directed RNA polymerase subunit 10-like protein
Sequence:
MADDDYNEVDDLGYEDEPAEPEIEEGVEEDADIKENDDVNVDPLETEDKVETEPVQRPRKTSKFMTKYERARILGTRALQISMNAPVMVELEGETDPLEIAMKELRQRKIPFTIRRYLPDMSYEEWGVDELIVEDSWKRQVGGD
Protein: DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase III) (P46588)
Organism: Candida albicans (Yeast)
Function: This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSHSIPITSSPPPALKKLKLPNGSEEPSEFERELLDITQAVHDSTDQTWDRPPLPSSFEDISFQQLDAEEYHDRGNTYARFFGITQEGHSVLCNVTGFIHYFYCPVPKGFEENLTEFTNYLKATFDGIERVEITSKESIWGYSNNIKTPFFKIFAKNNISKIRSAFQNGQVHNIDPCITYDNINYLLRLMIDCKITGMSWITLPRDKYKIVNNKISTCQIECSIDYRDLISHPPEGEWLKMAPLRILSFDIECAGRKGVFPEAEHDPVIQIANVVQKSGESKPFVRNVFTVNTCSSIIGSQIFEHQREEDMLMHWKEFITKVDPDVIIGYNTANFDIPYVLNRAKALGLNDFPFFGRLKRVKQEIKDAVFSSRAYGTRENKVVNIDGRMQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDVQHSIITDLQNGTKETRRRLAVYCLKDAFLPLRLLDKLMCLVNYTEMARVTGVPFSYLLSRGQQIKVISQLFRKCLQEDIVIPNLKSEGSNEEYEGATVIEPERGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLNKNSIKAFGLTEDDYTKTPNGDYFVHSNLRKGILPTILDELLTARKKAKADLKKETDPFKKDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAFGREMIEKTKNEVQEYYSKKNGHPYDAKVIYGDTDSVMVKFGYQDLETCMKLGEEAANYVSTKFKNPIKLEFEKVYFPYLLINKKRYAGLYWTRPEKFDKMDTKGIETVRRDNCRLVQNVITKVLEFILEERDVPKAQRFVKQTIADLLQNRIDLSQLVITKAYSKHDYSAKQAHVELAERMRKRDPGSAPTLGDRVAYVIIKTGGDKNYEKSEDPLYVLENSLPIDVKYYLDQQLTKPLERIFIPILGETKTKELLTGSHTRTIKVAAPKTGGLLRFAKKSEVCVSCRTPLKKDNLGALCPNCIKDGKGPDLYGNALSQMNYLENKFSRLWTECQRCQGSLHQEVLCSNKDCPIFYMRTKAQKDVHQQALELVKWDNTNW
Protein: Epididymis luminal protein 25 (V9HWG0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
Protein: Letm1 RBD domain-containing protein (Q38CI8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Transmembrane protein
- ATP synthase alpha chain
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MQGSWSVLKKNCSNFFPGLLAFAQQTQEAYGIWLRIYNRQQKYGPTDFVEQSETFSPDYHKRFHSQDKNMWVDKELCTEVSQKEVARLMTYKLDMWRMAHCAGALLATGGYAIPFGLFWLANDTWVPSSFNLTGEELRAWREAQDLYRYRSAPSYLTDTKWHFDFHAYPWNETQERAWDDLFEKNDVRRDPKVVRPAAEMYDGFIKFELIRRKSLRHLCRSMNIPTFPMLARLCNGTRVRDYWNLAWCEDYMVITQRLHESMTDEELYDYAWRRYLAPYDKNLNREQLMERVEDYFEFLGPDFVAHGKAPNLVILTNYVLGYYNDPAYLEGDISELDKNDYDHLASWGKDAFLRRLEFENGPLRDQVEAHTQRLLAERAAIAKGDNAAAVEGRHTA
Protein: Thrombospondin type-1 domain-containing protein 7B (Q9C0I4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFPKSNLTVTCWVWRSMRKLFLLLSLLLSHAAHLEGKKDNQFIWKPGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKGWSLQPLDPDGRVKIWVYGVSGGAFLIMIFLIFTSYLVCKKPKPHQSTPPQQKPLTLAYDGDLDM
Protein: Rho guanine nucleotide exchange factor (GEF) 7b (Rho guanine nucleotide exchange factor 7b isoform X4) (F1QA07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}.
Interaction partners:
Sequence:
MSENSAPQVLVKARFNFQQTNEDELSFSKGDIIQVTRQEEGGWWEGALNGKTGWFPSNYVKEIKGSDKPVSPKTGTLKSPPKAIESANFCKTYYNVVVQNILQTETEYCKELQNLLSVYLRALQPTDRLSVSDISHIMGNLEEISSFQQTLVHSLEENVKVSDSQQRIGGFFLSLLTQMRSLYVTYCSNHPSAVNVLTQHSEELGEFMESKGANTPGILTLTTGLSKPFLRLEKYPTLLKEMERHMEPLHPDYPDIQKSMTLFKNLSAQCQEVRKRKELELQILMESIRGWEGEGIKTLGTVLFMSQVIIQNHGAEEKNERYLLLFPHILLMLSASPRMSGFIYQGKLPLTGMSVSKTEDSDGTKHAFEISGNMIERIQVICNNQQDLQDWVDHLHRQTKRISTSSLKPQSVPCHTLPSHPLTPSRHSESRGVSGSPVYHTLPHLSSLGTPHSGMMWGPLEPPKTQKPWSLSCLRPAPPLKPSAALCYKEDLSKSPKNMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSRSRKESGPHMLFPEEEKIIVEETKSNGQTVIEERSLVDTVYALRDEVQELKQDNKRMKRTLEEEQKARKELEKVVRRVLKSMNDPSWDETNL
Protein: RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (O57513)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MNEVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPKPNTFIIRCLQWTTVIERTFHVETPEEREEWTKAIQTVADSLKKQEEEMMDFRSGSPSDNSGAEEMEVSMTKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLSPEAKSLLSGLLKKDPKQRLGGGPDDAKEIMQHKFFAGIVWQDVYGKKLVPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMDCVDNERRPHFPQFSYSASGTA
Protein: Kinesin-related protein 10 (Kinesin family member 10) (Kinesin-8) (Q6S002)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with kif8 and dynein to organize interphase microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Kinesin-related protein 2
- Microtubule-associated protein RP/EB family member 1
- Kinesin-related protein 8
- Kinesin-related protein 13
- Kinesin-related protein 12
- Uncharacterized protein
Sequence:
MNNNNNNNNNKTTMNSMIVTVRIRPESQSEILNKNCKTIVRVIDDNMLVFDPNDIDIGAFNNNRNNKQSQQPVEQKYIFDRVFDQYATQEEVFENTTKELVSYVISGHNASVFAYGASGAGKTHTMVGGINTGPGIMVLTMKELFSLIEKDRSNQYIVSMSYLEVYNETIRDLLITNTGGGGNSNNKVLELCEDENKQIVIRDLSWEYPTSADQVFKLLKYGNLNRKQSPTQTNQTSSRSHAVLQITVKQQNLQDKSKISFGKLSLIDLAGSERASKTLNTGDRLKEGTSINKSLLALGNCIKALGELCKNQQSQQQSSNPNFIPYRDSKLTRILKDSLTGSCKTIMIANISPNSSSFEETHNTLKYAQRAKSIKTQITKNVFASSTNLITQYNEIIKEQREEIKQLKLKLIQATSNNNNSNNNNNNNNNNYFSNSFGSCGNKNQPIKQPTPPTSLFHQQNQKYYRNDDDDDDDNDQEENNDEVLINEDDEEVDGEDSNNRDNDESMIQQLEEMSLLINSNLQDTLTLKKTQSIQRQRKRELENELKSLEKQQQSILNENNNVDIIKRTNEIGSQILKIKTLESSINEKLEMNNQWRRKLQSELTLKFVNSPKNLKILIQQARAATLELDRFDLTERMIDDRSKLNLKTNECKSLKDSLSWMFGILSDGFKLLTENNLATDDFLKDFLKSGDLINNLDNSFIINENNDSNNNNIIENDDIDLSFNNDINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNVPLNCNNSNSNINNKNQNIINPSPLKPRRIMSGSNNIIKSTNSNSRMTSTATTTAASTATATTTTIGKEKKGEIRSIVNPINKISSSTSLLPSSSTKISNTTPLYSRTSILRKRTLEIDDSTDSNPRTKKINVSSPVVTKPKQLLPSTTTATTTTLSSPLVNKPKQILPTTSSLQPKPHTKIQPHKNNNNNNNNIAPQMNMNIQIPNPIPIPIPMHVQIPISNPIPMPSPSSMNLKEKLDSLSQLCNNRSAKNENYNHNNSFNSQNPFVHPLQMHPPQLQLPLHPPQTMIMQSNMDLKMKLDSLSFFNNNNNNHQAQNDLSFDYGQNTLSNENLILHNKIASLSSTLINQPHPMRVKKLTPTSTISSSISTRPITTSTTTSTTVPSVVSNRIKSLVHSNSPIKENLYKEKLSSTASATLTPNRNNSQIVQPFKRGVLGNGPTSSSSRLLPSSRTTVNTSRKIIK
Protein: U-box domain-containing protein 14 (EC 2.3.2.27) (E3 ubiquitin-protein ligase PUB14) (Plant U-box protein 14) (Prototypical U-box domain protein 14) (RING-type E3 ubiquitin transferase PUB14) (Q8VZ40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase with specific E2 ubiquitin-conjugating enzymes. Undergoes auto-ubiquitination.
Interaction partners:
- E3 ubiquitin-protein ligase SINAT2
- E3 ubiquitin-protein ligase ATL6
- Pre-mRNA-processing factor 19 homolog 1
- Pre-mRNA-processing factor 19 homolog 2
- E3 ubiquitin-protein ligase RGLG2
Sequence:
MGLTNCCSHEELMSRLVDSVKEISGFSSSRGFIGKIQGDLVRRITLLSPFFEELIDVNVELKKDQITGFEAMRIALDSSLELFRSVNGGSKLFQLFDRDSLVEKFRDMTVEIEAALSQIPYEKIEVSEEVREQVQLLHFQFKRAKERWEESDLQLSHDLAMAENVMDPDPIILKRLSQELQLTTIDELKKESHAIHEYFLSYDGDPDDCFERMSSLLKNLVDFVTMESSDPDPSTGSRIVSRHRSPVIPEYFRCPISLELMKDPVIVSTGQTYERSSIQKWLDAGHKTCPKSQETLLHAGLTPNYVLKSLIALWCESNGIELPQNQGSCRTTKIGGSSSSDCDRTFVLSLLEKLANGTTEQQRAAAGELRLLAKRNVDNRVCIAEAGAIPLLVELLSSPDPRTQEHSVTALLNLSINEGNKGAIVDAGAITDIVEVLKNGSMEARENAAATLFSLSVIDENKVAIGAAGAIQALISLLEEGTRRGKKDAATAIFNLCIYQGNKSRAVKGGIVDPLTRLLKDAGGGMVDEALAILAILSTNQEGKTAIAEAESIPVLVEIIRTGSPRNRENAAAILWYLCIGNIERLNVAREVGADVALKELTENGTDRAKRKAASLLELIQQTEGVAVTTVP
Protein: AF4/FMR2 family member 4 (Q9ESC8)
Organism: Mus musculus (Mouse)
Function: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:22195968}. Note=Associates to transcriptionally active chromatin but not at snRNA genes.
Interaction partners:
- Cyclin-dependent kinase 9
- RNA polymerase II elongation factor ELL2
- RNA polymerase II elongation factor ELL
- Cyclin-T1
- Protein AF-9
- Btk-PH-domain binding protein translocated to, 1)
- AF4/FMR2 family member 1
- Cyclin-T2
- RNA polymerase II elongation factor ELL3
- ELL-associated factor 1
Sequence:
MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDYIGDRSIPKLVAIPKPAVPTTTDEKANPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSALQSGHSSQRSGAGGSGASSSGQRHDRDSYSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLSSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRGPFSSGQHSSQSFPPSLMSKSSSMLQKPTAYVRPMDGQESVEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSRPLDASVSGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGPGEQKRYSTAKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQAYKKEGREQGTASNYTDPGGTKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKPEKSAAEEPRGGLKIESETPVDMAASMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSASKPSQKSREIIETDTSSSDSDGSESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHSREVQKQASEKASNKGKRKHKNDDDTRASESKKPKTEDKNSSGHKPSSSRESSKQSSTKEKDLLPSPAGPILSKDSKTEHGSRKRTVSQSSSLKSSGTSSKENSGSSSKSSSSSTAKQKKTEGKGPSSSKEAKEKAPNSSSNCPPSTPTSESSKPRRTKLAFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSDTVELIKYTMKLKNYLAPDATAADKRLTVLCLRCQSLLYLRLFKLKKENALKYSKTLTEHLKNSYSNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGSYSSGGSSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLARYTRQGLHWLRQDAKLIS
Protein: STXBP4 protein (Q08AL9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITRAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEETYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQKS
Protein: Coiled-coil domain-containing protein 124 homolog (O94389)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative uncharacterized protein C1347.14c
- Uncharacterized transporter C36.02c
- Putative inorganic phosphate transporter C23D3.12
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS3
Sequence:
MGNPKKRAEKAEAAKSRKQDEEKKKKDAEEDEKWSKGVKTNKKEQEAEKRKAALERKAERERLEKEEMESLPSKGGKGSKKAAKKNSSLDAFLNETPQTASYSARNIDDALDLLSLNNSSSKDKIDRHPERRFKAALTEYKQSRLPELRKEQPGLRLNQYEDIMYKEFQKHPDNPFNKMNVSYNTSQDEVEQLRKARKAELEARLRE
Protein: Exocyst complex component EXO70C1 (AtExo70C1) (Exocyst subunit Exo70 family protein C1) (Q9FY95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28356503}. Note=Localized in the cytoplasm of pollen tubes and trichoblast cells. {ECO:0000269|PubMed:28356503}.
Interaction partners:
- Exocyst complex component SEC6
- Exocyst complex component SEC8
- Exocyst complex component SEC5A
- Exocyst complex component SEC5B
- Exocyst complex component SEC3A
- Exocyst complex component EXO84C
- Exocyst complex component SEC10a
- Exocyst complex component EXO84B
- Exocyst complex component SEC10b
- Exocyst complex component SEC15B
Sequence:
MEKSGNHHHANESSENHDHKSEDHENKQHSDELHSSTPESQSESSEHSLVEVMEAVVDFIQTLSSEKDPLGEISPAVESFPEAVDSLVSKMESSGLGRDETEDSVFIDAVNRISKSVMRLRELKLDSTPVSSWLNRASSVQHRAVSLLDEEFRHLLDRSREEEKKNNNNNNHHDGSNSDHNNSSTNDSDRCVLQDHEEAEEESFHDFSPESISTLKKIAGAMISAGYEAECCMSYEMSRRHAFKEELTEVGFEGINVEDVQRIGWESLEGEIASWISIVRRCSTVLFPGELSLCNAVFPDQDHSSVRKRLFTGLVSAVTIRFLDFSGAVVLTKRSSEKLFKFLDMYETLRDLIPAVEQSDSDLIQEIKLAQTRLGEAAVTIFGELEKSIKSDNGRTPVPSGAVHPLTRYTMNYLKYACEYKETLDQVFQHYEANQTDNKPEPETKPRQQQREDDEEYKVSAFARQMIRVMELLDANLEIKSRLYRDPSLRFIFLMNNGRYILQKIKGSIEIRDLMGQSWTRKRSTELRQYHKSYQRETWGKVLQCMNQEGLQVNGKVSKPVLKERFKIFNAMFDEIHKTQSTWIVSDEQMQSELRVSISSLVIPAYRSFFGRYKQHLDSGKQTDKYVKYQPEDIESFIDDLFDGNPTSMARKR
Protein: Uncharacterized protein VPS63 (O13549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Putative uncharacterized protein VPS61
- GTP-binding protein YPT6
Sequence:
MKEVTKMLYCALLVTKVIYQMKGKSQPKRERKKQNYWVLKSLWKRPQRQAIMSKLYSKRLPNRCLNFKTASQLLWIAKMQIVQTKINRESLIFLQQRSRNKALVSVST
Protein: Jerky protein (Q60976)
Organism: Mus musculus (Mouse)
Function: May bind DNA.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583}.
Interaction partners:
Sequence:
MASKQAAAKGKGEKRKRVVLTLKEKIDICTRLERGESRKALMQEYNVGMSTLYDIKAHKAQLLRFFASSDSRQALEQRRTLHTPKLEHLDRVLYEWFLVKRAEGIPVSGPMLIEKAKDFYKQMRLTEPCVFSGGWLWRFKARHGIKKLDASSEKQAADHQAAEQFCGFFRSLAAEHGLSPEQVYSADETGLVWRCLPNSAPDDGTVPHFKQGKDRLTVLMCANATGSHRIKPLAIGKGGGPRAFRGIQHLPIAYKAQGNAWVDKEIFSDWFHHIFVPSVREHFRTIGLPEDSKAILLLDHSRAHSQESELVSENVFTIFLPSSVTSLLQPTEQGIRRAFMRLFINPPVAFQGFPTRHNINDAIVNVARAWNAVPSQVFQRAWRKLWPTVTFTEGSSSEEEAECCAIKPHKTFAHILGLVKEGPTCSGSRLQDSRVEERVVAGRDIDEAPAIVAPSQATRCTKKSEKDTGETEEAAWEQAATSFEALVRFAERQPCFSVQEMGQLQALHTVFRRQQQLRQPRVALRAVIKLEALQEHPGVCVATTHPTLPCSSTAGDN
Protein: At1g27700/T22C5_14 (Syntaxin/t-SNARE family protein) (Q940U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046280}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00046280}.
Interaction partners:
Sequence:
MTTSLDRWEKDPFFPAAEEVQESADRMESAYRTWLNGKRDSSKVWDSEQLHRDLHAALGTTKWQLDEFQKAVKSSYDNRLSDETRDRHREFTFVMEAQVSKIEKSLKEAAQSDGKGTPRWVRLDEDDRNELALFLTGPSESAKANPNGHRRTASAAEFSAWNIAVSDDGLVKKSCDEPVVRPPRKVPSFSGFLNYMDPVSKHCNRKWKGLDRQGDSDAALLPIQANQQDMNGCSERGKSCMECEEDCYEKQLHGWYGALQRQLQRSQYRMRYSKSVHAAIWIILLVFLIVVVAVHSM
Protein: Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT) (P35761)
Organism: Mus musculus (Mouse)
Function: Phosphorylates proteins on serine, threonine, and tyrosine (By similarity). Probably associated with cell proliferation (By similarity). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (By similarity). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (By similarity).
Interaction partners:
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Kinetochore protein NDC80 homolog
- Mitotic spindle assembly checkpoint protein MAD1
- Mitotic spindle assembly checkpoint protein MAD2A
- Kinetochore protein Nuf2
- Kinesin-like protein KIF11
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Disks large-associated protein 5
- Non-SMC condensin I complex, subunit G
- Kinesin-like protein KIF2C
Sequence:
MEAEELIGSSVTIDSIMSKMRDIKNKINEDCTDELSLSKICADHTETVNQIMRVGNTPENWLNFLLKLEKNSSPLNDDLLNKLIGRYSQAIEVLPPDKYGQNESFARIQVRLAELKAIQEPDDARDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPLQMLETAMRNLHLQKKQLLPEEDKKSVSASTVLSAQEPFSSSLGNVQNRSISCESRGQAGAARVLYGENLPPQDAEVRHQNPFKQTHAAKRSCPFGRVPVNLLNSPDFYVKTDSSAVTQLTTRLALSSVPLPYVTCLLHLQLLALAGLAKGSGPDRDAILPGSRPRGSDSYELRGLKPIQTIYLKDSLVSNEKSSELMSDLIALKSKTDSSLTKLEETKPEIAERRPMQWQSTRKPECVFQNPAAFAPLRHVPDVTPKADKESPPISVPKWLDPKSACETPSSSSLDDYMKCFKTPVVKNDFPPACPSSTPYSQLARLQQQQQQGLSTPLQSLQISGSSSINECISVNGRIYSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEITEQYIYMVMECGNIDLNSWLKKKKSINPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPFQHIINQVSKLHAIINPAHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLTHPYVQIQPHPGSQMARGATDEMKYVLGQLVGLNSPNSILKTAKTLYERYNCGEGQDSSSSKTFDKKRERK