wanglab/gogpt-training-data huggingface dataset:
Protein: Erythropoietin (P07321)
Organism: Mus musculus (Mouse)
Function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Subcellular location: Secreted.
Interaction partners:
- Erythropoietin receptor
- Thrombopoietin
- Granulocyte colony-stimulating factor
- Leptin
- Prolactin
- Prolactin-6A1
- Prolactin-5A1
- Ciliary neurotrophic factor
- Tyrosine-protein kinase JAK2
- Thrombopoietin receptor
Sequence:
MGVPERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILEAKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMEVEEQAIEVWQGLSLLSEAILQAQALLANSSQPPETLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDTTPPAPLRTLTVDTFCKLFRVYANFLRGKLKLYTGEVCRRGDR
Protein: glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (Q8IDD3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Small ribosomal subunit protein eS30
- Glutamyl-tRNA
- 40S ribosomal protein S11
- 40S ribosomal protein S11, putative
- 60S ribosomal protein L6, putative
- 60S ribosomal protein L38
- 60S ribosomal protein L30e, putative
- 60S ribosomal protein L23
- 60S ribosomal protein L29
- 40S ribosomal protein S24
Sequence:
MIFIYFFFVTLIIINLNTIESKYLFGYSYNGNPKCPINILYDKKYIYSFILNNNKRNTYNSRIKCAKKSSIIPNEIVEGKVRLRFAPSPTGFLHVGGCRTFLYNYILSKQMNGSLILRLEDTDIKRNTKDSLDEIIKDLNWLNLTWDEGPDKVGEYGPYKQSEKIQLYKKIAHQFVNEGKAYFCFCSKEELQEIKEKSKMMKKKYIYNRKCRDMNNEQIKMKLEQNIAYTIRFKSPLKRKIILKDILKGDIIDEVLEDFIILRSNELPTYNFSVSVDDYLMKITHVIRGVEHISNTFKQILILETLNADIPHYAHIPVITTEEKKKISKRNNEYLIRNLREEGFKPECVVNYMTTLGWGSISKKEIYTMSELIDTFNIHKLNKSSVVFDIKKLKWMNKKYMLEQDNETYVREAEEYMINNNILSSNEYKEFVELCVDIFKYEVHNYSELKECILNALKYEHHVNDPLNTDDIYLKQVSFLLYDWFRKNDVKDNTEYLEMKMIDDFDSLIDDIVKSTNLKKNQVLLKIRLLLTFQSKGIPFIYLIKLWASARKHNIPNYFSLKKRFLHLKNLFKF
Protein: UDP-galactose transporter (SD16302p) (UDP-galactose transporter, isoform A) (UDP-galactose transporter, isoform C) (Q9W4W6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNSIHMNANTLKYISLLTLTLQNAILGLSMRYARTRPGDIFLSSTAVLMAEFAKLITCLFLVFNEEGKDAQKFVRSLHKTIIANPMDTLKVCVPSLVYIVQNNLLYVSASHLDAATYQVTYQLKILTTAMFAVVILRRKLLNTQWGALLLLVMGIVLVQLAQTEGPTSGSAGGAAAAATAASSGGAPEQNRMLGLWAALGACFLSGFAGIYFEKILKGAEISVWMRNVQLSLLSIPFGLLTCFVNDGSRIFDQGFFKGYDLFVWYLVLLQAGGGLIVAVVVKYADNILKGFATSLAIIISCVASIYIFDFNLTLQFSFGAGLVIASIFLYGYDPARSAPKPTMHGPGGDEEKLLPRV
Protein: WD40 repeat-containing protein SMU1 (Q9VE18)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
- Beag
- Microfibrillar-associated protein 1
- Grasp65
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- U6 snRNA-associated Sm-like protein LSm8
- Pre-mRNA-processing-splicing factor 8
- Splicing factor 3B subunit 3
- LD44732p
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein Sm D3
Sequence:
MSIEIESADVIRLIQQYLKESNLMKTLQTLQEETGVSLNTVDSVDGFVQDISNGHWDTVLKVTQSLKLPDKKLLNLYEQIVLELIELRELGAARSLLRQTDPMTMLKQQEPERYIHLENMLQRAYFDPREAYAEGSSKEKRRTVIAQELSGEVHVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAMKDQEEEMYPTQLFRQIKFGQKSHVECAQFSPDGQYLITGSVDGFLEVWNFTTGKVRKDLKYQAQDQFMMMEQAVLALNFSRDSEMVASGAQDGQIKVWRIITGQCLRKFEKAHTKGITCLQFSRDNSQVLSASFDYTVRLHGLKSGKMLKEFKGHSSFVNEATFTPDGHSVLSASSDGTVKVWSLKTTECVATYKPLGNELAVNTVLILPKNPEHFIVCNRSNTVVIMNMQGQIVRSFSSGKREGGAFISATLSPRGEFIYCAGEDQVLYCFSVSSGKLERTLNVHEKDVIGLTHHPHQNLLASYSEDGLLKLWKP
Protein: CUB domain-containing protein (Q21330)
Organism: Caenorhabditis elegans
Interaction partners:
- NT-3
- CUB_2 domain-containing protein
- SNF2 N-terminal domain-containing protein
- CUB_2 domain-containing protein
- ShKT domain-containing protein
- SCP domain-containing protein
- Potassium channel domain-containing protein
Sequence:
MVSILFFLATLVASAFADGYTCANIMRNPTQNLSEPYYYPETWRENMEPTKYAPNQICNWQINVPEGLYATVIFYKKTDSESGIKCTYPNGEQVYIEDNDQNPYKFTYPRFQIDLQVGDKQGEFSFKVVWSEYPDGRSMYIGLDGVHSIASVPTSYYTTVTAVNQVMLVGFSVPDVPLALLRQSAIYEGGYTNGTYLGNLVNARSGQIYSTSNKLGVYTFGLEKFINQTVFMVLDSRAAGDIVQYTGTNCPTDPNKSCGIFLNSQKNVSAVATISRQPDYLTLPKGFANSITLKIYGETMEESNLFATINSNYQSMFPLRVTNSLKIYHSDTGLLTVPVAKNADAAKWNSVFDGRYIIVRSFDFNRQSYAQDTTETFVTDPNNQMYFKFNVKYLDTNGPTTLDVNVYKNGVAVFTATYTATNPPLPFPNGILGDKMEVNYQTYGNYTQGFQVDILTTKNGDASPSSQSPVSTPSTVTMSPSTLTTKIITSTKSDSPTTFPTLAPGASTTIGTGATRGTTQRYESTTKSGINKFSLTTLAIVGFVMLV
Protein: Present in the outer mitochondrial membrane proteome 34 (Q57XA5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTGPSTTLAGSGCLTVALAGAAVVVSAVTYISNKRRSALSTIAANRGGFQSVSVQPQTKGNVAGQDASSANNRGVPHSTFPQSNTGPTNRSYYYAFAERHVKRHNATTMEWRDDVLGVRMLFSPILFAVETEERQAPLLLVGLRYLRQPEHRVAITFEYCETEETAENYRELSLERVCDCAKLLSGTGNIRIGSAQLPSAEYCYLDRGNKLRFALSVFLTSKRLAVTAQYIADTRVKSVLPTAFNELVRSIQFSEPRSSPSYLLCAEPRLGLGFRLPLDFVMDEHLRELLTIAEETTVTSATPRASGGEGPNGSASHSALRRIDKEGRNSSNGPRAAGNAAPSTPDVLWGFSVPHQLPDLCAVEHATGGGRYGFLGNGETNGNSDSVSVQFVTISSLGPRRIVVVACYEPLPAGNFSWQTFFEHHLRAVVRRFSVHHSTDGSNAYSVSVVRSNDELQCAKSGKQRNFVVQLQQIMVPTNGDSAGEDDPNPTLQLEGALCVQEVLIDPNNVCAAHLRHPQGRRSDGDALSPTDLMHMHTDKAGPSGEAFISAYLSVFCLRIRSECVSMCFLFPTACHTLEEVVTFCRRTIDTMSLGNHYGQSTSLIYCNKRHEVLPFSILLNPACAAAAATVVVREPIMGEPLAAFCVGGMDGLTVHLRVFPIPFVAHTSQVARRRATSRLEKLVRDYLLRLPGRVCVHHWETTMLGASAALEVHYEQLCDSDDDDGDSDSFVMDNDMGRFNPFSFLGSPYCHEGHDMEGAECPQEQHTPVIGMSASAVGSSVLSRSAEHMLLRAPSLDSREESTTLQVAVVVCCEGCAFLFLASLEGYPLAAVRQVVRQFASNLSVSTGVTA
Protein: Putative lipoprotein LpqT (P9WK59)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Ribose-phosphate pyrophosphokinase
- Bifunctional protein GlmU
- Large ribosomal subunit protein bL25
- Peptidyl-tRNA hydrolase
- Lipoprotein LpqB
Sequence:
MAGRRCPQDSVRPLAVAVAVATLAMSAVACGPKSPDFQSILSTSPTTSAVSTTTEVPVPLWKYLESVGVTGEPVAPSSLTDLTVSIPTPPGWAPMKNPNITPNTEMIAKGESYPTAMLMVFKLHRDFDIAEALKHGTADARLSTNFTELDSSTADFNGFPSSMIQGSYDLHGRRLHTWNRIVFPTGAPPAKQRYLVQLTITSLANEAVKHASDIEAIIAGFVVAAK
Protein: Beta galactosidase, isoform A (EC 3.2.1.23) (LP09580p) (Q9VMJ5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Alpha-galactosidase
- Glucosylceramidase
- Glucosylceramidase
- beta-N-acetylhexosaminidase
- beta-N-acetylhexosaminidase
- Aldose 1-epimerase
- Aldose 1-epimerase
- Galactose mutarotase
- Aldose 1-epimerase
- Aldose 1-epimerase
Sequence:
MSGCRRNRKLTMAVSGCLIIAVMALTVGLCVGLSGDTDAPEEQPRFTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALDTYVEWSLHNPHDGEYNWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSIKMRTNDPNYISEVGKWYAELMPRLQHLFVGNGGKIIMVQVENEYGDYACDHDYLNWLRDETEKYVSGKALLFTVDIPNEKMSCGKIENVFATTDFGIDRINEIDKIWAMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRDGQEVANALRTILSYNASVNLYMFFGGTNFGFTAGANYNLDGGIGYAADITSYDYDAVMDEAGGVTTKYNLVKAVIGEFLPLPEITLNPAKRLAYGRVELTPKLTLLSTEGRAALSKGDPVESIKPKTFEELDLYSGLVLYETELPSMDLDPALLKIDQINDRAHVFVDQELVGTLSREAQIYSLPLSKGWGSTLQLLVENQGRVNFYISNDTKGIFGEVSLQLHNGGYLPLENWRSTAFPLEQSAVELWRREHTDEKALDPLLARQRILRNGPILYTGSLTVTEVGDTYLNMAGWGKGVAYVNGFNLGRYWPVAGPQVTLYVPNEILKVGENSLVILEYQRANKTATGEDLPAVQFDAVAQLDGESGDVPLK
Protein: Cytokine induced apoptosis inhibitor 1 (H3BPG7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADFGISAGQFVAVVWDKSSPVEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEILAEIARILRPGGCLFLKEPVETALQREPLTPEEVQSVREHLGHESDNLLFVQITGKKPNFEVGSSRQLKLSITKKSSPSVKPAVDPAAAKLWTLSANDMEDDSMHLWPCRRTGKREVKGTDELPTQVSLWKLLPGRCLPLCQLPLPWDASLQTWGKGASE
Protein: Zinc finger protein 59 (Zfp-59) (Zinc finger protein Mfg-2) (P16373)
Organism: Mus musculus (Mouse)
Function: May have a role during differentiation processes.
Subcellular location: Nucleus {ECO:0000269|PubMed:8547218}.
Interaction partners:
Sequence:
MASTNSQDMVCGSVTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAVVGSCISKPDLIVLLEQEKEPWMAVNEETGRPSPDLEADYDAENISPQNRIYNRKFSKQSIKQLSRTFDPKGSWFSNGPNYSTFHGLRDCQSDAGQQITNKEGVPPHTCQTLAHNTEKPYECKECGKCFGCRSTLTQHQSVHTGEKPYECKECGKAFRLPQQLTRHQKCHSGEKPFSHNEGRQAFQHPNLLKYPKAIHTGAKAFACRECGKSFNRVSSLVEHGLIHADVKPYECNECGKAFKRHRSFVRHQKIHSGERPFQCKDCGKGFIVLAHLTRHQSSHSEEKPFECEECGKKFRTARHLVKHQRIHSGEKPFECNVCGSAFRLQLYLSEHQKTHMEEKYLECNVCGKAFRLQVYLSEHLKTHTEENPFKCKLCGSAFPNKYQLNKHLTVHTDGKPYQCKECGKCFRQRSKLTEHESIHTGKKPFQCEECGKFFRLNTLLIHHQKSHSGERPFECKECGKAFLLPSQLNSHKIVHTSKRPFECKVCGKSFKRESNLIQHGAVHAGVKSYECSECGKGFIHRSSLFHHRKIHSDEKPFKCQECGKAFVVLAYLIQHQSIHTGEKPFECELCGSAFRCRSQLNKHLRIHTDVKLFQCVED
Protein: Intraflagellar transport protein 46 homolog (Q9VJ72)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
- No mechanoreceptor potential B, isoform D
- Intraflagellar transport 52
- Intraflagellar transport protein 57 homolog
- GH11140p
- Outer segment 5
- TRAF3-interacting protein 1
- Intraflagellar transport 20
- Intraflagellar transport protein 122 homolog
- Outer segment 6
- Intraflagellar transport protein 172 homolog
Sequence:
MNFYDEEITIGGPDSKHLSSVQMEPRNGGTGGGRGGAGGGGPGAVGGEGAVRRAAAGRHRRMFQNNSTDDDGLLQDIIDHDDEAEDSEDDDDSEMQLPQGMTMGVGMTGLVPGPNMQKRPGSNRSSKQVPDDTLSSGSEEAAMGGRMGSGGARGGAKLPHQKLTLPMRGSASGAGRSKRQDDQSFIMSADKWEDLSVPGELKELFPYIVKYTPQTIDTPFHLQPFIPEFVPAVGDVDALLKVQAPPLLQPQRQKDLNDHLEKLGLWLLDEPSGAQSEPSLLNMKLRSVLSGSMGRNPRHASSASLVPTARSGKDIEKWITEVEQVHMTQSMYDVQPRKDIDALLEDWPRSFGDEQTINALDQAYRSCLQQNISVAEYVGVLCERFGVEGPLESQADYIHNVQTLFALYLAASQAWE
Protein: Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein) (Q9Z186)
Organism: Mus musculus (Mouse)
Function: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Hexokinase-4
- Hexokinase-1
- Hexokinase HKDC1
- Hexokinase-3
- Hexokinase-2
- Phosphoglucomutase-1
- Glucose-6-phosphatase catalytic subunit 1
- GDH/6PGL endoplasmic bifunctional protein
- Glucose-6-phosphate isomerase
- Glucose-6-phosphatase 3
Sequence:
MDFLHRSGVLIIHHLQEDYRTYYGFLNFMSNVGDPRNIFSIYFPLWFQLNQNVGTKMIWVAVIGDWFNLIFKWILFGHRPYWWIQETEIYPNHSSPCLEQFPTTCETGPGSPSGHAMGSSCVWYVMVTAALSYTISRMEESSVTLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGVHMASLSVYLKTNVFLFLFALGFYLLLRLFGIDLLWSVPIAKKWCANPDWIHIDSTPFAGLVRNLGVLFGLGFAINSEMFLRSCQGENGTKPSFRLLCALTSLTTMQLYRFIKIPTHAEPLFYLLSFCKSASIPLMVVALIPYCVHMLMRPGDKKTK
Protein: Leucine-rich repeat-containing protein 18 (Q8N456)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of spermatogenesis and sperm maturation.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- WD repeat- and FYVE domain-containing protein 4
Sequence:
MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNLISPNSMAKDSWEDWRIRLTSS
Protein: PMS1 homolog 1, mismatch repair system component (Postmeiotic segregation increased 1 (S. cerevisiae)) (Q8K119)
Organism: Mus musculus (Mouse)
Interaction partners:
- DNA mismatch repair protein Mlh1
- DNA mismatch repair protein Msh6
- DNA mismatch repair protein Msh3
- DNA mismatch repair protein Msh2
- MutS protein homolog 4
- Mismatch repair endonuclease PMS2
- MutS protein homolog 5
- MutL homolog 3
- DNA excision repair protein ERCC-1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
Sequence:
MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGATSIEVKLENYGFDKIEIRDNGEGIKAVDVPVMAVKYYTSKISSHEDLGNLTTYGFRGEALGSICNVAEVVVTTRTSADDFSTQYVLDGSGHILSQKPSHLGQGTTVTALKLFKNLPVRKQFYSTAKKCKDELKNVQDLLISYGVLKPDVRITFVHNKAVIWQKSRVPDHRMALMSVLGTAVMGNMESVEQHCEQSQIYLSGFFPKHDADHNSTSLSTPERSFIFINSRPVHQKDILKLIRRYYNLKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLMMTCYGPLPTTESSENNRVDISSANMVVSQTAETDVLFNKMESFGNNYPNADTSAIHFQKDESRKNIDHHLNEQINIGNYFDGHFSGDINKDTFQNIPMNNLSSETNQSNHSETHSVGSMEHIQGENGRNGTGGSGGDGRETLPEKALEICADDWSKGNLCNSMGENIEPVKILVPQKSLSCKVTSSHPRLEPETLSDGPCSRTSDVIHNRSGRLTAYDLISSRAVKKPMSASALFIQDHRTQFLTENPKTGLEDATEQIKARWETLSEEEKHKYEEKAKKDLERYNNQMKKAIEQETQVSLKDGRKKRATSSWGWTQKHKVKDSSNQPKLDELFQSQNEKKKSENIKITEIPFSMENLKANLKKQKEVDLEEKDEIYLIHSLKFPDSWLVTSRADVMLLNPYRVEEALLFKRLLENHKLLAEPLEKPIILTESLLNGSHYLEVLYKMSTVEERGSGSAYLCDPRLTANGFKIRLTPGVSSTENYLEIEGMAQCLPFYGIMDLKEILNAIVNKNAKEIYECRPRKVINYLEGEAVRLSRQLPMYLPREDVQDLIYRMKHQFGKEIKGCVHGRPFFHHLTHLPGTS
Protein: Paired immunoglobulin-like receptor B (Q8K4V6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MSCTFTALLCLGLTLSLWIPVLTGSLPKPILRVQPDSVVSRWTKVTFFCEETIGANEYRLYKDGKLYKTVTKNKQKPANKAEFSLSNVDLSNAGQYECSYSTQYKSSGYSDPLKLVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGPQKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELLVSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEGSQKTQSTQTLQQPGNKGKFFIPSMTRQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEHYKPRLSVLPSPVVTAGGNMTLHCASDFHYDKFILTKEDKKFGNSLDTEHISSSRQYRALFIIGPTTPTHTGTFRCYGYFKNAPQLWSVPSDLQQILISGLSKKPSLLTHQGHILDPGMTLTLQCYSDINYDRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVKPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQNSSFYLLSSASAPVELTVSGPIETSTPPPTMSMPLGGLHMYLKALIGVSVAFILFLFILIFILLRRRHRGKFRKDVQKEKDLQLSSGAEEPITRKGKG
Protein: Dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic (EC 2.3.1.12) (Dihydrolipoamide S-acetyltransferase component 5 of pyruvate dehydrogenase complex) (Protein EMBRYO DEFECTIVE 3003) (Pyruvate dehydrogenase complex component E2 5) (PDC-E2 5) (PDCE2 5) (Q9C8P0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Subcellular location: Plastid, chloroplast stroma {ECO:0000250}.
Interaction partners:
- Dihydrolipoyl dehydrogenase 2, chloroplastic
- Dihydrolipoyl dehydrogenase 1, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic
- Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic
- Dihydrolipoyl dehydrogenase 1, chloroplastic
- Dihydrolipoyl dehydrogenase 2, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic
- Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial
Sequence:
MSRLLQTPFLPSVSLPTKTRSSVTGFRVKPRIIPIQAKIREIFMPALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEEGGVAPVGSAIALLAETEDEIADAKAKASGGGGGGDSKAPPASPPTAAVEAPVSVEKKVAAAPVSIKAVAASAVHPASEGGKRIVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAVAAGGGVQAAVAVKEVVAAPGVELGSVVPFTTMQGAVSRNMVESLGVPTFRVGYTISTDALDALYKKIKSKGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNSSINVAVAVAIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMAVGASQPSVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIEDPKDLTF
Protein: Mucin (F4IL92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Rhomboid-like protein 20
- Rhomboid-like protein 18
- Autophagy-related protein 8f
Sequence:
MEGDGFKEKLSDSVLIDEKLEEYSDCDQTSTTSPSPVQDKVANTRSFRSNSMKVNQDEFFIEDFDVGPMYTIDLYDMTFREDPSDFDDNLLYAMRDRTKQLRSFKRKIMDAIKSKRRREKEYEQLAIWFGDADMGCDLVDNKEHATTSIDSKSSQSNVPVVSEDSEWELL
Protein: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) (Q09171)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- Probable pyruvate dehydrogenase protein X component, mitochondrial
- Probable dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Glutathione reductase
- Pyruvate kinase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Pyruvate carboxylase
Sequence:
MIRLQKFGEIVGTSRSWKLLSSTIAKRYSSSSNGVKEMTVRDALNSAMEEEMKRDDRVFLIGEEVAQYNGAYKISRGLLDKFGPKRVIDTPITEMGFTGLATGAAFAGLRPICEFMTFNFSMQAIDHIVNSAARTLYMSGGIQACPIVFRGPNGPAAAVAAQHSQHFAPWYGSIPGLKVVSPYSAEDARGLLKAAIRDPNPVVVLENEILYGKTFPISKEALSEDFVLPFGLAKVERPGKDITIVGESISVVTALEAADKLKADYGVEAEVINLRSIRPLDINTIAASVKKTNRIVTVDQAYSQHGIGSEIAAQIMESDAFDYLDAPVERVSMADVPMPYSHPVEAASVPNADVVVAAAKKCLYIK
Protein: Cytokine-inducible SH2-containing protein (B5XCB4)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- Elongin-C
- Cullin-5
- Cullin-5
- Cullin-5
- Elongin-B
- RING-box protein 2
- RING-box protein 2
- Cullin-2
- Erythropoietin receptor
- Erythropoietin receptor
Sequence:
MILCVQGPRPLLSGTPTEGHLGMRTGSVSSPHCIHSTSPQWDPTKDLRTIANNTFYLDTSGWYWGAITAGQAHAALQTASEGAFLIRDSSHPLYMLTLSVRTARGPTSIRIQYSGARFLLDSSSPARPSLLSFPDVPSMVQYYVGPGRKVQQGKVEETHCGKPAQRTVQESTVLLKLKRALHKPQAFPSLQHLARLTINCSTDCPDQLPLPRPLVRFLQDYPFQV
Protein: 2-O-methyltransferase NoeI (EC 2.1.1.-) (FkbM family methyltransferase) (U0002kb) (P95136)
Organism: Mycobacterium tuberculosis
Interaction partners:
- Glycosyl transferase
- Glycosyl transferase
- FkbM family methyltransferase
- FkbM family methyltransferase
- Fucose synthetase
- Glycosyl transferase family protein
- Fucose synthetase
- Class I SAM-dependent methyltransferase
- Glycosyl transferase family protein
Sequence:
MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVFDVGANSGQYAAGLRRAAYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGTVTINIAGNAGQSSSVLPMLKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFLKVDVQGFEKQVLAGGKSTIDDHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTGLLPCFIDANNGRMLQADGIFFREDD
Protein: Protein sprouty (Spry) (O44783)
Organism: Drosophila melanogaster (Fruit fly)
Function: Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10089881, ECO:0000269|PubMed:9458049}; Peripheral membrane protein {ECO:0000269|PubMed:10089881, ECO:0000269|PubMed:9458049}; Cytoplasmic side {ECO:0000269|PubMed:10089881, ECO:0000269|PubMed:9458049}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Growth factor receptor-bound protein 2
- Raf homolog serine/threonine-protein kinase Raf
- GTPase-activating protein
- Threonylcarbamoyladenosine tRNA methylthiotransferase
- Mitogen-activated protein kinase ERK-A
- Epidermal growth factor receptor
- Protein giant-lens
Sequence:
MDRRNGGDPLAPPRPPKLLPRVHRPRAPEPTLSGVDHNAGATASALASGASSAAPVAIHNNNSQQQLSISAAASNNNTISIIPASPDFDDYQIHHLTFLPQRPSSLSRNSSTASSTTATGISVSGSGSVSGSSSSFTRRRPPAPVPLNNSISNNNNNSINNNFLSHFQSAEPASNALGQPPASPVTLAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTTHHLLLLPQRNQHLHLQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTDGLLHSHLQNSTTKPPASKQPAPPRLGMGLGLGLGLGLNQPIITKQPTPATQKERMHALEELLQPGGAGGNGGPLVMAGDPSLLNPIVCPRCGRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCLCCAKALFYHCARDNDLDCDDGNGTPCVDNPCSCGPYKRTQRWGWLGALSIFLPCLWFYWPMRGCMKLCEKCYGRFAGRGCRCQGIGGGGAGSGGGVGSIGSTSSMLPIVPLGVNGSGLGGGVSLSGGVTDGGLNQANGKAMDHGCSAARSILRKGDLTPEKRLLDSSPDY
Protein: V-type proton ATPase subunit e1 (V-ATPase subunit e1) (Vacuolar H(+)-ATPase subunit e isoform 1) (Vacuolar proton pump subunit e1) (Q9FLN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18507826}; Multi-pass membrane protein {ECO:0000269|PubMed:18507826}.
Interaction partners:
- V-type proton ATPase subunit c''1
- V-type proton ATPase subunit c''2
- V-type proton ATPase subunit H
- V-type proton ATPase subunit C
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit F
- V-type proton ATPase subunit D
- V-type proton ATPase subunit c3
- V-type proton ATPase subunit c1
- V-type proton ATPase subunit a1
Sequence:
MGFLITTLIFVVVGIIASLCVRICCNRGPSTNLLHLTLVITATVCCWMMWAIVYIAQMNPLIVPILSETE
Protein: Protein FAM110A (Q9BQ89)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:17499476}. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.
Interaction partners:
- Centrosome and spindle pole-associated protein 1
Sequence:
MPVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLSKQPLFSPETRRTVLTPSRRALPGPCRRPQLDLDILSSLIDLCDSPVSPAEASRTPGRAEGAGRPPPATPPRPPPSTSAVRRVDVRPLPASPARPCPSPGPAAASSPARPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPGSSEGGCSRRSSVTVEERARERVPYGVSVVERNARVIKWLYGLRQARESPAAEG
Protein: small monomeric GTPase (EC 3.6.5.2) (B5XGC1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSVTAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGRNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPIEKKKEKKSNCTLL