wanglab/gogpt-training-data huggingface dataset:
Protein: Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) (Q7SZC2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). Negatively regulates fluid secretion and plays a role in fluid homeostasis by down-regulating cftr activity.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:20933420}. Nucleus {ECO:0000250|UniProtKB:P55060}. Apical cell membrane {ECO:0000269|PubMed:20933420}; Peripheral membrane protein {ECO:0000305|PubMed:20933420}. Basal cell membrane {ECO:0000269|PubMed:20933420}; Peripheral membrane protein {ECO:0000305|PubMed:20933420}. Lateral cell membrane {ECO:0000269|PubMed:20933420}; Peripheral membrane protein {ECO:0000305|PubMed:20933420}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:P55060}.
Interaction partners:
- Importin subunit alpha
- Importin subunit alpha
- Karyopherin alpha 1
- Exportin-T
- GTP-binding nuclear protein Ran
- Adhesion G protein-coupled receptor D1
- Exportin-6
- Importin subunit beta-1
- Exportin 1
- Exportin-4
Sequence:
MELNDGNLQTLTEYLQKTLSADPAVRRPAEKFLESVEGNQNYPILLLAVLEKSQNEVIRVCSAVTFKNYIKRNWRIVEDEPNKISDPDRTAIKANIVNLMLTSPEQIQKQLSDAISIIGREDFPLKWPDLLTEMVNRFQSGDFHIINGVLRTAHSLFKRYRHEFKSNELWSEIKLVLDTFAQPLTELFKATIELCQTHATDINALKVLFSSLTLISKLFYSLNFQDLPEFFEDNMETWMTNFHNLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQPYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKHLFEDQNVLTSICEKVIVPNMEFRSADEEAFEDNSEEYIIRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLAEYAKNPGVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLSEFFLNHILIDLKSPNVNEFPVLKSDAIKYVMTFRSQLPKEQLLQAVPLLVSHLQAESIVQHTYAAHALERLFTMRGGNNTTLITPTEMAPFTEQLLNHLFKALAIPGSSENEYIMKAIMRSFSLLQEAIVPYIPTLIGQLTHKLLLVSKNPSKPHFNHYLFESLCLSIRITCKANPDTVSSFEEALFPVFTEILQNDVQEFVPYVFQVMSLLLEIHSNSIPSSYMALFPHLLQPVLWERTGNIPPLVRLLQAYLEKGAAAIANTASDKIPGLLGVFQKLIASKANDHQGFYLLNSIVEHMPAEAITQYRKQIFILLFQRLQSSKTTKFVKSFLVFINLYSVKYGAIALQEIFDDIQPKMFGMVVEKIVIPEVQKVSGQVEKKICAVGIIKILTECPAMMDTEYTKLWAPLLQALIGLFELPEDDSIPDDEHFIDIEDTPGYQTAFSQLAFAGKKEHDPIGDAVSNPKILLAQSLHKLSTACPGRVPSMLSTSLPTEALQFLQGYLQAATVQLV
Protein: Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6) (P47880)
Organism: Mus musculus (Mouse)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Subcellular location: Secreted.
Interaction partners:
- Insulin-like growth factor 2
- Insulin-like growth factor 1
- Insulin-like growth factor-binding protein 1
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor-binding protein 5
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- Insulin-2
- Insulin-1
Sequence:
MTWDGLPTQPLLMLLMLLFAAGSGSALAGCPGCGAGMQTGCRGGCVEEEDAGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQCQPRENEEAPLRALLIGQGRCQRARGPSEETTKESKPQGGASRSRDTNHRDRQKNPRTSAAPIRPNPVQDSEMGPCRRHLDSVLQQLQTEVFRGGARGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPMGQPLPVSPDGQGSTQCSARSSG
Protein: Collagen type V alpha 2 chain (A0A8I6AII1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MMANWVVARPLLILFVLLGYCVSIKAQEQENDDYDEEIACTQHGQMYLNRDIWKPSPCQICVCDNGAILCDKIECQEVLNCANPVTPPGECCPACPQTSGGGDTSFGRGRKVKGLPGYYEIVTGIRGRPGPAGPPGSQGPRGDRGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPIGPRGPQGLQGQQGGVGPAGPPGEPGEPGPMGPIGARGPEGPPGKPGEDGEPGRNGNTGEVGFSGSPGARGFPGAPGLPGLKGHRGNKGLEGPKGEVGAPGAKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGVKGEAGPTGARGPEGPQGQRGETGPPGPAGSHGLPGAVGTDGTPGAKGPTGSPGTSGPPGLAGPPGSPGPQGSTGPQGIRGQLGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPGTVGPPGPMGERGAPGNRGFPGSDGLPGPKGAQGERGPIGSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDLGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGEPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGNPGPTGTIGDTGPPGLQGMPGERGIAGTPGPKGDRGGVGEKGAEGTAGNDGARGLPGSLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPHGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPIGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGSPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGEPGSRGPVGPPGRAGKRGLPGPQGPRGDKGDNGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGLLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDENMPDPLPEFTEDQAAPDDTNKTDPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHPTKQSGEYWIDPNQGSAEDAIKVYCNLETGETCISANPASVPRKTWWASKSPDNKPVWYGLDMNRGSQFTYGDYKSPNTAITQMTFLRLLSKEASQNLTYICKNTVGYMDDQTKNLKKAVVLKGSNDLEIKGEGNIRFRYTVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDIGPVDIGNADQEFGFEIGPVCFM
Protein: Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (O13947)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Putative thiosulfate sulfurtransferase, mitochondrial
- Biotin synthase
- tRNA modification GTPase mss1
- Probable cysteine desulfurase, mitochondrial
- Adenylyltransferase and sulfurtransferase uba4
- Protein MTO1 homolog
- Mitochondrial oxaloacetate transport protein
Sequence:
MRVSLFLQKQIIECSKAFQPHSTRLQWPKSQDKVFVAMSGGVDSSFSAYLLKSQGYNVEGVFMRNWLDEDSAPSGCPAERDWATVQKVCKKLNISCRRFNFEKEYWNLVFEPSLDLYENGLTPNPDVSCNRQVKFGALFDALKKHCENNVKGDWWLASGHYAKSVVNIETNESHMCIPTDKRKDQTLFLCTIRKEALEKTIFPLHNWTKENVKKQASSAGFKEIAEKQESQGLCFVSPNVGRKFRKFLQRYLNFSDRPIKVIAGKNVVGEFSGNHGIWSLTVGERCGLSLPQAQSEYFGRWYVWKKDIKNNALYICRGTNNELLMSKCIYLKDWKWCGTKLQNLEKSALSCFVRVRHQQPLQPAKVTWRNPESVKIHFQDKQRAVTPGQVIAVYVNDVCLGGGMVDTVEPEKDFD
Protein: Metallo-beta-lactamase domain-containing protein (O17598)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRRNLLYNFYITFYILLSISSFFVECCDKGLTQLRHKDTLQLMRCVPTLPGHPDPCILQTGGQMSFCQPDGSQDYVCCGTPELLVRLVGNQNKQSYPENWNFYPRQSHYDYSVYIRSSKEQLESDAAFKNQVILTTPKTTTTTVTTTRKRQPVKKSNVVLQMLTIPSLSRGNYSNSLKLHTNSVLVRDGACVFVVDTGLPSQKKQISKNLASYGAPAKKIKFVVVTSSQPQFSGNLNLFPFSQFIMADATMYKDNIVFMKRFEKHSILELCSPNSLIQSTPGPTPNSITVIIRNVDLMGTIAIAGALFPNGNDLNVFDRNSVYDIDKLIESRNQVICEVDWIVPASSSPFRVTQLHRTNANC
Protein: Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD) (Q91ZW6)
Organism: Rattus norvegicus (Rat)
Function: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11431483}.
Interaction partners:
- 4-trimethylaminobutyraldehyde dehydrogenase
- Organic cation/carnitine transporter 2
Sequence:
MWYHKLLHQQSRLQNLMKRGDIAHGLRLSGFKSLFPFSLHWCHTASKSVNCTWHQHEDHLELQYASTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDESTLFFTWPDGHVTRYDLDWLVKNSYEGQKQEVIQPRVLWNAKLYQDAQLPSVDFQGFLETKEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLARRVSLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAQQVLQRAPEEFDLLSQVPLKHEYIENVGQCHNHMIGVGPILNIYPWNKELYLIRYNNYDRAVINTVPYDVVRRWYAAHRTLTTELRRPENELWVKLKPGKVLFIDNWRVLHGRESFTGYRQLCGCYLTRDDVLNTARILGLHA
Protein: MYB-like transcription factor ETC2 (Protein ENHANCER OF TRY AND CPC 2) (Q84RD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MYB-type transcription factor involved in epidermal cell fate specification. Acts as a negative regulator of trichome development, by mediating lateral inhibition. Promotes the formation of hair developing cells in H position in root epidermis, probably by inhibiting non-hair cell formation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor EGL1
- Transcription factor GLABRA 3
- Homeobox-leucine zipper protein GLABRA 2
- Protein TRANSPARENT TESTA GLABRA 1
- Transcription factor MYC1
- Uncharacterized protein At2g30430
- Protein TORMOZ EMBRYO DEFECTIVE
- Zinc finger protein GIS2
- Zinc finger protein 8
- Transcription factor MYB21
Sequence:
MDNTNRLRLRRGPSLRQTKFTRSRYDSEEVSSIEWEFISMTEQEEDLISRMYRLVGNRWDLIAGRVVGRKANEIERYWIMRNSDYFSHKRRRLNNSPFFSTSPLNLQENLKL
Protein: Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like) (Q9BXA5)
Organism: Homo sapiens (Human)
Function: Receptor for succinate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15141213}; Multi-pass membrane protein {ECO:0000269|PubMed:15141213}.
Interaction partners:
- Pro-neuropeptide Y
- Hydroxycarboxylic acid receptor 2
- Renin
Sequence:
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
Protein: Traffic jam, isoform B (Q9VIW0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKMEDPTINDTYVQEFDLHHLEVGGNGAGQSHGAGAASQVTTLGHVKREDHSPPQPVAVKWTTIHGDPTNPDDDPDSLPLSGPEPAGAVEVSPSPHIKLRSFSGHHQWHMDERRLQPLSPPPEQYGPLPGQAILVNTSSGAGVPGGVPSTPPETPPVVGSPTGSSSCPAQTYAHHYARTPGSSVSVSASAAAAAAASAGAASVSAGLSHDMMWLTNSIRADQQPLDLRPLPYPGSQEEAEEWDRQRDYALQAAAAHHHHHGQPLMQAQHHPHGHGGHPHQVMLQQSKYPHHHHHHFHNLELTPINMHSNSYGSASGALTPTCLPQVPSNGSGSSGGGGGSGSGSGGPGSVGGGSCVITRAALQPCRPLSASSTRSSNNMSPRTCSGAYSNATLEDCLNDDMLTTLTVRELNKRLHGCPREEVVRLKQKRRTLKNRGYAQNCRSKRLHQRHELEKANRVLNQDLHRLKLEYSRVCQERDALMQRLQRAANGGVGAGGATAGGDSQSSPEFYL
Protein: UPF0060 membrane protein YnfA (P76169)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00010, ECO:0000269|PubMed:11867724, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00010, ECO:0000269|PubMed:11867724, ECO:0000269|PubMed:15919996}.
Interaction partners:
- UPF0482 protein YnfB
- Starvation-sensing protein RspA
- Probable D,D-dipeptide transport system permease protein DdpC
- Inner membrane protein YiaB
Sequence:
MIKTTLLFFATALCEIIGCFLPWLWLKRNASIWLLLPAGISLALFVWLLTLHPAASGRVYAAYGGVYVCTALMWLRVVDGVKLTLYDWTGALIALCGMLIIVAGWGRT
Protein: E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) (O75928)
Organism: Homo sapiens (Human)
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q8C5D8}. Nucleus, PML body {ECO:0000269|PubMed:12716907, ECO:0000269|PubMed:22406621}. Nucleus {ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12393906}. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). {ECO:0000250|UniProtKB:Q8C5D8, ECO:0000269|PubMed:22406621}.
Interaction partners:
- Small ubiquitin-related modifier 1
- SUMO-conjugating enzyme UBC9
- Small ubiquitin-related modifier 2
- Signal transducer and activator of transcription 3
- Androgen receptor
- E3 SUMO-protein ligase NSE2
- Signal transducer and activator of transcription 1-alpha/beta
- Parkinson disease protein 7
- Cellular tumor antigen p53
- Signal transducer and activator of transcription 4
Sequence:
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSSHESSTHVSSSSSRSETGVITSSGSNIPDIISLD
Protein: Uncharacterized protein YPL071C (Q02864)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MSSRFARSNGNPNHIRKRNHSPDPIGIDNYKRKRLIIDLENLSLNDKGPKNGHADDNNLIHNNIVFTDAIDDKVLKEIIKCSTSKRGDNDLFYDKIWERLREKRLQIIKWVDYKEIAYLSWWKWFHNQMTSKYTYDGEADTDVEMMAVDTDVDMDA
Protein: UL37 protein (Q8UZ12)
Organism: Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Interaction partners:
Sequence:
LQAATVLRPVERFLARWDLVSAALRRAVDERGVLALVATLRETWTEAREEQAPPAPAFTPEELREAADRVLGDYHEVAGDGEAGPDAVPLSASVNVRDWAAVNLEVLRRGARAPDDASAGVPLLAQTWVPVDRLLAEVDAVSK
Protein: Dual specificity protein phosphatase 1-A (EC 3.1.3.16) (EC 3.1.3.48) (XCL100) (XCL100-alfa) (Q91790)
Organism: Xenopus laevis (African clawed frog)
Function: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-188' and 'Tyr-190', regulating its activity during the meiotic cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:7593328}.
Interaction partners:
Sequence:
MVNMETCAMDCCVLKALLAERAHKCLILDCRSFFSFSSCSIVGSSNVRLSTIVKRRAKGSMGLEHIVPNEEQRCRLVAGMYEAVVLLDERTSELDMLRKDSTMMLAVNALCRDSRGSSIYFLKGGYETFSAQCPEFCTKNSPPVGLSLPLCANNVPGSADSNCTPCGTPLYDQGGPVEILPFLYLGSAYHASRKDMLDTLGITALINVSANCPNHFEGHFQYKSIPVEDSHKADISSWFNEAIDFIDSVKNSGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPSCSAEAGSPTISVLDRGTSTTTVFNFPVSIPVHSGANSLSYLQNPITTSPSC
Protein: Trans-acting factor D (REP-antagonizing factor) (Recombinase-activating factor) (RAF) (Q06891)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in 2-micron plasmid partitioning. Antagonizes transcriptional repression of recombinase FLP by REP1-REP2. Regulates both stability and copy number of the plasmid by blocking the formation of the REP1-REP2 repressor complex.
Interaction partners:
Sequence:
MPYKTAIDCIEELATQCFLSKLTDDDVSTFRRVCSKENDIIKLALRIPRTIDYTSILRLLYDTLPLRSLSFNEALPLFCYSIDPAQQRQCDLRFYLRDVVKLARPRKRLEMQKALLQWLPSLLSDVTLQLLNDIRIRFEEIQPNIRQTVLQIYDRTCYPSLNFEHPNLGVFPETDSIFEPV
Protein: Bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (EC 2.7.1.24, EC 2.7.7.3) (Q9VRP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- pantothenate kinase
- Phosphopantothenoylcysteine decarboxylase
- 4'-phosphopantetheine phosphatase
- Phosphopantothenoylcysteine synthetase, isoform C
- L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
- LD38259p
Sequence:
MASSTGLLVVSNIKHLGKSLRAIEKYVNSLYIHLNVAGSTSTTSPVPPPPVWGRLISQLYANSSSYVGKQLDLRVLVSPLRPGANGSLKLRQPVDLIFSDAHHPELCDRLRADLNISKPTIFLDDSVISDLSAQQDDTQPPKVYPSVVLGGTFDRIHLGHKIFLTQAVLRTCKRLVVGVTTSAMTKGKTLPDLILPVEERIARLREFLVDIDDTLQYEIVPIDDPFGPTQVDPDLDMIVVSAETLRGGQKVNEVRSAKQLRELEIFVIDIVESNVHDGIHETKVSSSNTRIDLLGTRWRRPEPRPQLPPRPYIIGLTGGIASGKSKMGERLANMGAHVIDCDKVAHDVYEPGQLCYTRIVQHFGQGIVSDDGRIDRSKLGPLVFADPKQLQALNGIVWPELIAEVNRRLDALRSQADVPRVVVLEAAVLLRAGWETNCHEVWSMIVPPDEAVRRIIERNKLSEVEAQKRLASQVPNSEIVAKSHVIFSSQWDHEFTQKQAERAWKMLTKELDSYQSSL
Protein: Carbonic anhydrase-related protein (CARP) (Carbonic anhydrase VIII) (CA-VIII) (P28651)
Organism: Mus musculus (Mouse)
Function: Does not have a carbonic anhydrase catalytic activity.
Interaction partners:
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Sequence:
MADLSFIEDAVAFPEKEEDEEEEEEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGQEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQMQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ
Protein: Cadmium-induced protein CadI (P9WIR5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable arsenic-transport integral membrane protein ArsC
- Possible transcriptional regulatory protein
- Probable cation efflux system protein Rv2025c
- Multicopper oxidase MmcO
- Possible transcriptional regulatory protein
Sequence:
MSRVQLALNVDDLEAAITFYSRLFNAEPAKRKPGYANFAIADPPLKLVLLENPGTGGTLNHLGVEVGSSNTVHAEIARLTEAGLVTEKEIGTTCCFATQDKVWVTGPGGERWEVYTVLADSETFGSGPRHNDTSDGEASMCCDGQVAVGASG
Protein: Amphiphysin, isoform C (A0A0B4KFR7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTENKGIMLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQAASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPEMKKKVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPALYDSRILFLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATESQRGSNTLRKQTSNPIKTSSPVQSPVNKLNNANINSNYQNQITTNGGSSLANSHANTADLPPGVLYRVKATYGYAKEDVDELSFEIGDLIRVIEYDDPEDQFFIANLQEEGWLMGQKEGTNEKGLFPANFTRPI
Protein: Vomeronasal type-1 receptor 53 (Pheromone receptor VN5) (Vomeronasal receptor 5) (Vomeronasal type-1 receptor B3) (Q9EP93)
Organism: Mus musculus (Mouse)
Function: Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Olfactory receptor
Sequence:
MNKANLLHTDINLKITLFSEVSVGISANSILIFAHLCMLLGENRPKPIDLYIAFFSLTQLMLLITMGLIAVDMFMPWGRWDSTTCQSLIYLHRLLRGLTLSATCLLNVLWTITLSPRSSCLTKFKHKSLQHISCAFLFLCVLYMSFNSHLFISIIAYPNLTLENFMYVTQSCSLIPLSYFRKSMFSIPMAIREALLIGLMALSGGYMVAHLWRHKKQAQHLHRTSLSSKASPEQRATRTIMLLMSFFVVLYILDLVIFHSRMKFKDGSILYGVQIIVSHSYATVSPFVFICTEKRITNFLRSMCGRIVNI
Protein: Vacuolar protein sorting-associated protein 45 (P38932)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for vacuolar protein sorting. Function in membrane traffic between the Golgi and the vacuole.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12756236}. Vacuole membrane {ECO:0000269|PubMed:12756236}; Peripheral membrane protein {ECO:0000269|PubMed:12756236}; Cytoplasmic side {ECO:0000269|PubMed:12756236}. Note=Cycles between the cytoplasmic side of the vacuolar membrane and the cytoplasm.
Interaction partners:
- t-SNARE affecting a late Golgi compartment protein 2
- Vacuolar segregation protein PEP7
- t-SNARE affecting a late Golgi compartment protein 1
- t-SNARE VTI1
- Syntaxin PEP12
- Integral membrane protein SED5
- Syntaxin VAM3
- Synaptobrevin homolog 2
- Synaptobrevin homolog YKT6
- Alpha-soluble NSF attachment protein
Sequence:
MNLFDVADFYINKIVTSQSKLSVANVNEHQRIKVLLLDKNTTPTISLCATQSELLKHEIYLVERIENEQREVSRHLRCLVYVKPTEETLQHLLRELRNPRYGEYQIFFSNIVSKSQLERLAESDDLEAVTKVEEIFQDFFILNQDLFSFDLQPREFLSNKLVWSEGGLTKCTNSLVSVLLSLKIKPDIRYEGASKICERLAKEVSYEIGKNERTFFDFPVMDSTPVLLILDRNTDPITPLLQPWTYQSMINEYIGIKRNIVDLSKVPRIDKDLEKVTLSSKQDAFFRDTMYLNFGELGDKVKQYVTTYKDKTQTNSQINSIEDIKNFIEKYPEFRKLSGNVAKHMAIVGELDRQLKIKNIWEISEIEQNLSAHDANEEDFSDLIKLLQNEAVDKYYKLKLACIYSLNNQTSSDKIRQLVEILSQQLPPEDVNFFHKFKSLFSRQDKMTQSNHDKDDILTELARRFNSRMNSKSNTAENVYMQHIPEISSLLTDLSKNALFRDRFKEIDTQGHRVIGNQQSKDIPQDVILFVIGGVTYEEARLVHDFNGTMNNRMRVVLGGTSILSTKEYMDSIRSAK
Protein: Tropinone reductase homolog At2g29290 (EC 1.1.1.-) (Q9ZW13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING-type E3 ubiquitin transferase
- Myosin
- ATP binding / ATPase
- Pentatricopeptide repeat-containing protein At1g31920
- At5g27290
- ARM repeat superfamily protein
- 1-aminocyclopropane-1-carboxylate oxidase homolog 5
- F3F19.21 protein family protein)
- Probable cytochrome c oxidase subunit 5C-3
- At3g12510
Sequence:
MDKRWSLQGMNALVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSICDVSLREQREKLMETVSSLFQGKLNILVNNVGTLMLKPTTEYTAEEFSFLMATNLDSAFHISQLAHPLLKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNIRTNAICPWLITTPLISDLLSVEEMKKEAEERTPMGRVGEANEVSPLVAFLCLPAASYITGQVICVDGGLTVNGFSYQPHA
Protein: Serine/threonine-protein phosphatase 1 (EC 3.1.3.16) (P55798)
Organism: Escherichia coli (strain K12)
Function: Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates.
Interaction partners:
Sequence:
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQSLRCLQLLEQHWVCAVRGNHEQMAMDALASQQMSLWLMNGGDWFIALADNQQKQAKTALEKCQHLPFILEVHSRTGKHVIAHADYPDDVYEWQKDVDLHQVLWSRSRLGERQKGQGITGADHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ
Protein: Cathepsin D (EC 3.4.23.5) (Ddp44) (O76856)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Protease that may act during cell growth and/or development.
Subcellular location: Lysosome {ECO:0000269|PubMed:10523518}. Secreted {ECO:0000269|PubMed:10523518}.
Interaction partners:
- Cysteine proteinase 1
- Peptidase C1A papain C-terminal domain-containing protein
- Cysteine protease
- Cathepsin B
- Cysteine proteinase 7
- Cysteine proteinase 5
- Battenin
- Cysteine proteinase 4
- Ceroid-lipofuscinosis neuronal protein 5 homolog
- Cysteine proteinase 2
Sequence:
MKLLILTLFLATIVLAQALTVPLNFHQASRESRRRVPQKWSNRLSALNAGTTIPISDFEDAQYYGAITIGTPGQAFKVVFDTGSSNLWIPSKKCPITVVACDLHNKYNSGASSTYVANGTDFTIQYGSGAMSGFVSQDSVTVGSLTVKDQLFAEATAEPGIAFDFAKFDGILGLAFQSISVNSIPPVFYNMLSQGLVSSTLFSFWLSRTPGANGGELSFGSIDNTKYTGDITYVPLTNETYWEFVMDDFAIDGQSAGFCGTTCHAICDSGTSLIAGPMADITALNEKLGAVILNGEGVFSDCSVINTLPNVTITVAGREFVLTPKEYVLEVTEFGKTECLSGFMGIELNMGNFWILGDVFISAYYTVFDFGNKQVGFATAIQG
Protein: GH17339p (GM10914p) (Rab27) (Q9W585)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Late endosome {ECO:0000256|ARBA:ARBA00004603}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTGANIDYDYLLKFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPNIAYGQPEDLVRLHDRREEPCSRRNCRNC
Protein: Uncharacterized RNA-binding protein C365.04c (Q9Y7Y3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome biogenesis protein bms1
- rRNA processing protein rcl1
- Putative ATP-dependent RNA helicase PB1A10.06c
- U3 small nucleolar RNA-associated protein 4
- rRNA biogenesis protein rrp5
- Uncharacterized protein C1604.06c
- U3 small nucleolar RNA-associated protein 20
- U3 small nucleolar RNA-associated protein 10
- ATP-dependent RNA helicase dbp10
- rRNA biogenesis protein rrp36
Sequence:
MSSKLSKKKLKSLEYRSKKFDKKSQSLEEHEKKVQQKNEELEKKAADKISRDELPEKQLAQSNDKDKHSVSNPPHKTLKSKRQKGKNNDRKVILFVGNLPKDSSVETLQLHFKRAGQVPSVRIPTDKTSGRQKGYAFVEFINPKTDVISKALKFHHTIYKERKINIELTAGGGGKTEARMNKIKEKNRKWKEEMRQRVASEEQQAGEEKMARKAVADEGLESGIHPDRLRLLQ