wanglab/gogpt-training-data huggingface dataset:
Protein: Histone-lysine N-methyltransferase ASHR1 (EC 2.1.1.-) (ASH1-related protein 1) (Protein SET DOMAIN GROUP 37) (Q7XJS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Calmodulin-lysine N-methyltransferase
- Mediator of RNA polymerase II transcription subunit
- Uncharacterized protein At2g34170
- non-specific serine/threonine protein kinase
- Histone-lysine N-methyltransferase ASHR3
- Histone-lysine N-methyltransferase ASHH2
- RBR-type E3 ubiquitin transferase
- Trihelix transcription factor DF1
- Histone-lysine N-methyltransferase ASHH1
- Ribose-phosphate pyrophosphokinase 3, chloroplastic
Sequence:
MADLQRFLQDRCLGVSNLPQKGRSLFTARDFRPGEVILSQKPYICVPNNTSSESRCDGCFKTNNLKKCSACQVVWYCGSSCQKSEWKLHRDECKALTRLEKEKRKFVTPTIRLMVRLYIKRNLQNEKVLPITTTDNYSLVEALVSHMSEIDEKQMLLYAQMANLVNLILQFPSVDLREIAENFSKFSCNAHSICDSELRPQGIGLFPLVSIINHSCSPNAVLVFEEQMAVVRAMDNISKDSEITISYIETAGSTLTRQKSLKEQYLFHCQCARCSNFGKPHDIEESAILEGYRCANEKCTGFLLRDPEEKGFVCQKCLLLRSKEEVKKLASDLKTVSEKAPTSPSAEDKQAAIELYKTIEKLQVKLYHSFSIPLMRTREKLLKMLMDVEIWREALNYCRLIVPVYQRVYPATHPLIGLQFYTQGKLEWLLGETKEAVSSLIKAFDILRISHGISTPFMKELSAKLEEARAEASYKQLALH
Protein: Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) (Q16555)
Organism: Homo sapiens (Human)
Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
Interaction partners:
- Protein numb homolog
- Dihydropyrimidinase-related protein 5
- Glycogen synthase kinase-3 beta
- Cyclin-dependent kinase 5
- Dihydropyrimidinase-related protein 3
- Numb-like protein
- Tyrosine-protein kinase Fes/Fps
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Ras-related protein Rab-27A
- Dihydropyrimidinase-related protein 1
Sequence:
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
Protein: Rab11 interacting protein, isoform E (X2JFP6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.
Interaction partners:
Sequence:
MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPDQGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYDRPRAKWFKLESKPGKEKKNKERGELEVRIAFVVKSGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLHIRSKKKNQEAGADDSSSFGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEADPGVISEDEDEFVFDNLSHKSSGSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVGSGSAKGKQAVLPATLDEDASIDAEMEQLELDFSVRAHARANANASASGNASTLPPPSKPPRIPLSQVDEQPAAGSLEREKPKEKPAEVESDKDEWASKLYGGGKYLEIGSSNSLKRRSWEDRVPLPASVEEPPPLHSSSSSSSSSSDSDDDDEKPPQAAPPPVPVPASLPVPSAAASTASADPVVATSSSLFSPDVEHRNFDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPKPQPRATADLRAEEEKAKEEAARQLRAEEDARLEAELRLNEERLREEEEAMQRELEEEKERQKQLQMDEQQRREAKRWEEDQRLLSFAKRSTSLEEPVPEKQELKHERELVAKQEPEKTLDTAEPEPEHNFLTPEQSPKEFQTNGSGSGSGERWEKRLGKFKYGNKRDKYNNDNDSNSPSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEGKSREELMLIANGMENEALLQRQRVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKSG
Protein: Adipolin (Adipose-derived insulin-sensitizing factor) (Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12 (Adipolin fCTRP12) (Adipolin full-length form); Adipolin gC1QTNF12 (Adipolin cleaved form) (Adipolin gCTRP12)] (Q8R2Z0)
Organism: Mus musculus (Mouse)
Function: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
Subcellular location: [Adipolin fC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362, ECO:0000269|PubMed:22942287}.; SUBCELLULAR LOCATION: [Adipolin gC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362, ECO:0000269|PubMed:22942287}. Note=In serum is the predominant form. {ECO:0000269|PubMed:22275362}.
Interaction partners:
Sequence:
MWAWGWAAAALLWLQTAGAGARQELKKSRQLFARVDSPNITTSNREGFPGSVKPPEASGPELSDAHMTWLNFVRRPDDGSSRKRCRGRDKKSRGLSGLPGPPGPPGPPGPPGSPGVGVTPEALLQEFQEILKEATELRFSGLPDTLLPQEPSQRLVVEAFYCRLKGPVLVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLHVDHSELQGRGRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQSGQYVSVFVDNSSGAVLTIQNTSSFSGMLLGT
Protein: Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1) (Q8N2U9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEAEGLDWLLVPLHQLVSWGAAAAMVFGGVVPYVPQYRDIRRTQNADGFSTYVCLVLLVANILRILFWFGRRFESPLLWQSAIMILTMLLMLKLCTEVRVANELNARRRSFTAADSKDEEVKVAPRRSFLDFDPHHFWQWSSFSDYVQCVLAFTGVAGYITYLSIDSALFVETLGFLAVLTEAMLGVPQLYRNHRHQSTEGMSIKMVLMWTSGDAFKTAYFLLKGAPLQFSVCGLLQVLVDLAILGQAYAFARHPQKPAPHAVHPTGTKAL
Protein: Urease (EC 3.5.1.5) (Urea amidohydrolase) (O00084)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:8742356}.
Interaction partners:
- Ureidoglycolate lyase
- Probable allantoicase
- Uncharacterized urease accessory protein ureG-like
- Uncharacterized urease accessory protein ureD-like
- Arginase
- Arginase
- Alpha-ketoglutarate-dependent xanthine dioxygenase xan1
- Uricase
- High-affinity nickel transport protein nic1
- Uncharacterized urease accessory protein UreF-like
Sequence:
MQPRELHKLTLHQLGSLAQKRLCRGVKLNKLEATSLIASQIQEYVRDGNHSVADLMSLGKDMLGKRHVQPNVVHLLHEIMIEATFPDGTYLITIHDPICTTDGNLEHALYGSFLPTPSQELFPLEEEKLYAPENSPGFVEVLEGEIELLPNLPRTPIEVRNMGDRPIQVGSHYHFIETNEKLCFDRSKAYGKRLDIPSGTAIRFEPGVMKIVNLIPIGGAKLIQGGNSLSKGVFDDSRTREIVDNLMKQGFMHQPESPLNMPLQSARPFVVPRKLYAVMYGPTTNDKIRLGDTNLIVRVEKDFTEYGNESVFGGGKVIRDGTGQSSSKSMDECLDTVITNAVIIDHTGIYKADIGIKNGYIVGIGKAGNPDTMDNIGENMVIGSSTDVISAENKIVTYGGMDSHVHFICPQQIEEALASGITTMYGGGTGPSTGTNATTCTPNKDLIRSMLRSTDSYPMNIGLTGKGNDSGSSSLKEQIEAGCSGLKLHEDWGSTPAAIDSCLSVCDEYDVQCLIHTDTLNESSFVEGTFKAFKNRTIHTYHVEGAGGGHAPDIISLVQNPNILPSSTNPTRPFTTNTLDEELDMLMVCHHLSRNVPEDVAFAESRIRAETIAAEDILQDLGAISMISSDSQAMGRCGEVISRTWKTAHKNKLQRGALPEDEGSGVDNFRVKRYVSKYTINPAITHGISHIVGSVEIGKFADLVLWDFADFGARPSMVLKGGMIALASMGDPNGSIPTVSPLMSWQMFGAHDPERSIAFVSKASITSGVIESYGLHKRVEAVKSTRNIGKKDMVYNSYMPKMTVDPEAYTVTADGKVMECEPVDKLPLSQSYFIF
Protein: DNA polymerase (EC 2.7.7.7) (Q77CC8)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Subcellular location: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
Interaction partners:
Sequence:
MDRDCEQGTAPPRAGFFNPYLAPRGRGAPARQGPDIPDGAGEAPADEAAGRGGGRAAESYCTAASSFRFIAPRCLDADGADGGTDDEAAGAAAPRRRGVHIGTAERAPKVYLDGEEHDILDFAGHCCWPRRVSVWAGRAAPERAALDPRFERFHVYDIVETTEYPSAGDASRFAAEARPGGATVVTLLGMSEDGKRVAVHVYGVRHYFYMEKAAVDLACGVRDEGQLIDAMVAALRSSALAAGAAQQDAAGRAGARRPGGYLGRASRDSLSVAVVEAADVYFYDTRPQLFYKVSSASARLGGYLCDNFLPGVTKYEGHVDVTTRFLLDNEGFTSFGWYRLRPGRAGARALRAPAQHATSCDVEVNCTADNLEPIAGAEADAWPDYKLLCFDIECLSCAGDGLAFPAAANAEDLVVQISCLTYSLRTQRHEHTLLFSLGSCDLPPAFLGACAAAGLPAPAVLEFDSEFELLLAFMTFLKQYSPEFVTGYNIVNFDWAYISEKLTAVYDVRLDGYGKLNRGGLFRVFDAGQNRFQKQSKVKINGVVSLDMYRTAVEKLKLPSYKLNAVAEEALRERKVDLDYKDIPRHFAAGPEGRGVIGEYCIQDSALVGKLFFKYLPHLELSAVARLAGITVSRAIFDGQQIRVFTCLLRLARARGFLLPDTQKRLAGAEAGAARGAGRGRGERFACWADAARGEEEEEDEGGEEDGGNEGRAGAADRPRAAGGRAVGYQGAKVLDPESGFHVDPVMVLDFASLYPSIIQAHNLCFTTLVRREAAPAGLTPGADYATFDVGGRALHFVRAHVRESLLSVLLRDWLAMRKAIRARIPTAAPEEAVLLDKQQAAIKVVCNSVYGFTGVSNGLLPCLAVAATVTTIGRDMLLETRRYIHERWATPEALVRDFPAAGPAAAAAGRYRVRVVYGDTDSVFVKFAGMPYDAVCALGDGMARRVSAALFRPPIKLECEKTFAKLLLITKKKYLGLVGGGKMLMKGVDLVRKNNCRFINAYTRRLVDVLMHDDAVSRAAAEASAVPPSEWPGRQLPPGFARFGAVLAEAHAKIADPALDIGDFVMTAELSRPPEAYANKRIAHLTVYYKLLLRSEARPNVKDRIPYVIVAPGEGVERDAAAVNALRGTAPSAPPGGGARPGRLLISDMAEDPGYARAHAVPLNTDYYFSHLLGTVGATFKALFGNDTRTTENLLKRFIPETRACDRRLQGRLAAAGFAALTPAAQSRQTLRTAFGILAAAPHQS
Protein: Protein transport protein SEC9 (Q59XP0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Late secretory t-SNARE protein required for secretion and proper cytokinesis. Plays an important role in the secretion of virulence-associated extracellular enzymes and vesicle-mediated polarized hyphal growth.
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- SNAP receptor
- Protein transport protein SSO2
- Uncharacterized protein
- Sec1p
- V-SNARE coiled-coil homology domain-containing protein
- Protein transport protein SEC22
- SNAP receptor
- Ras-related protein SEC4
- Rab GTPase-binding protein
- SNAP receptor
Sequence:
MGIKKMFQKKEPTEQEIREELSRVGISTRSNNTRQEKFGAFKNYAQERANMKPQLGPVGGNPYANINPGTNNNNNNPYANDNGNNSTGNPNNNSNSNNGGNPYGGGVTNNNPYGGSGGNGRGSSPSPYAPTTSTTTRSSNPYGNNNGSRSSQNTSSPYAKSTNNSSYSNSPYSGSTVNNGNRGGHSNNSNSSAGGNPYAAGGRSSQSQNSRDNVYTAPATRTSTRQTQGYGGGDTDSTLDLNAIPSHQMFDNKKPIKRNQQSSQQPANDYNLDLNDEYGEEEDLNLDISEVPEEQQQINSEDEEVEAIKQDIKFVKQESVQSTRNTLRMAQEADASGTNTLGMLGSQSERLYNAEQNLLLAETQTQIADEKVKELKRLNRSIFIPANGNPFNKKSRLRQQEEKIKNQKLQEKYIRENNRQEMFASEQRIKQGITNNSTNNDVYNKYQDEKNLSAAKRYQFENDSEDDDMEKEIASNLNQIDQYAKKLKGLANTMGTEVDNQNTRLKKIEESADKLDINVHMNTTRLNNIR
Protein: LD16414p (Slowdown, isoform A) (Slowdown, isoform B) (Q95RQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPEMIYSSSFLLLCCTILLLGTVQNAGSNSTSPHPHQNQTHRGHGHSHRTRHQGNYLATHQRQQRRLQSLNQAKSDVELLPGVTMHEVTRLRRVQPHNPYNKVQTRRLHQSRNPTEWDYNTYNIMTNTFGPPPPPMPLSPRYGKGEDNTQDVEFIGVRERGRGYSFVPSVTVTTAPPPNLNRRSASPGSRSSIGTIPPLVPARRGYSYTTTTSSPPVNTITTDNPFETNTIGRGYPTDPKEMERRHICMQQRTVTMPVKRTEVYSRPTWKHVATPCQPPTFSGQKCTRVQVVHEQAYRDVIDHKTAQQMTYDCCTGWSRENPRSDSCMKPICSARCQNGGNCTAPSTCSCPTGFTGRFCEQDVDECQTEKPCDQQCINTHGSYFCRCRQGFVLQSDQQSCKKVSTNADDAFEARDLENDIDDTDAEVATRLQKIEKSLANERVHTNELQKSLQATYSVVDTLKSRLSTLEKQAQDVSRLQTNLYKTESRTNKLEGMLNLLLKCRNGPNANCP
Protein: short-chain 2-methylacyl-CoA dehydrogenase (EC 1.3.8.5) (C8VQF1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
- Probable electron transfer flavoprotein subunit alpha
- Probable enoyl-CoA hydratase, mitochondrial
- Probable electron transfer flavoprotein subunit beta
Sequence:
MTMASITRVLRPLSRTVPSLRPAAIRPLASRPLQSTYAFSTTCRRREADLTGLTPTPITHLSETESMMAETVSKFAEEQIGPKVREMDEAETMDPALVEHLFEQGIMGIEIPEEFGGAGMNFTAAIVAIEELARVDPSVSVLVDVHNTLVNTAFIKWGDAQVQRTWLPKLATGTVGSFCLSEPVSGSDAFALQTKAEKTADGYKLNGSKMWITNSMEAGVFIVFANLNPSKGYKGITAFIVEKDTPGFSIAKKEKKLGIKASSTCVLNFDDVVIPKGNLLGEEGQGYKYAIGLLNEGRIGIAAQMTGLALGAWENAAKYVWNDRRQFGQLVGEFQGMQHQIAQAYTEIAAARALVYNAARKKEAGQDFVQDAAMAKLYASQVAGRVAGSAVEWMGGMGFVREGIAEKMFRDSKIGAIYEGTSNIQLQTIAKLLQKQYTR
Protein: ER-derived vesicles protein ERV14 (P53173)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.
Interaction partners:
- Endoplasmic reticulum vesicle protein 25
- Protein SVP26
- ER-derived vesicles protein ERV29
- Protein transport protein SEC24
- Protein ERP1
- Protein transport protein GOT1
- Endosomal protein P24B
- Axial budding pattern protein 2
- Protein EMP47
- Na
Sequence:
MGAWLFILAVVVNCINLFGQVHFTILYADLEADYINPIELCSKVNKLITPEAALHGALSLLFLLNGYWFVFLLNLPVLAYNLNKIYNKVQLLDATEIFRTLGKHKRESFLKLGFHLLMFFFYLYRMIMALIAESGDDF
Protein: Probable serine/threonine-protein kinase drkD (EC 2.7.11.1) (Receptor-like kinase D) (Q54TM7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MEGSFQFNKSKQTNNNSSLDSNNIINDNINNNLNFENNNNNNNNNNNNNNNNNNNNNNNNTNNNNTTNDTSKTSANSTSTEDDEEDILGNRKKDTTGSRVLPMDTSLTGAAEPSKKRKNTQDDSEVEVQYHPQKRASFSLNISPTQLQNDLSLNIFNVSNSNNNNNSNNNNNNNNNNNNNNNKINNNSNLILNSSVDSTTSSNNNNNKNSNDNQQPQQQPEEIEGELNRERQERDKMLHEEAEIEQYKYGDGEEGENYEIMVTPHHRTSFGHITSANSDETTNNESGSPINSRKMVTDEEDPHSSHNEDHQSDQDNHGQFMNDEHQSTDDDQNKSDNEKESESARNSGDLQQKVHNSKDESTVSTPQHIFNNGNGEGEEEDDDDEEYDVPLRIQTVANNKSTKLSLSNCWLKVIPTDVWSILELRDLDLSANQLKKVSKSIGLLVHLKRLRLNHNQLTALPKELYSLPRLTTLYLNNNNFKVVPKEINRLTSLKTLDLSFNQITDISPQTNLHQMTNLVELRLRYNQLSSLPQNMLESNHLQVLWLEGNRLPLNKAILKKSPSEILSFLRGYKPPNKKVNDKVINKAHVNPALPPIDTASTIAVAQVFAQKELDTKKRKKENLDDFKKQHIETELKLKQLEEELQIANAKATKFEEEASLLQQQFNNPNTPTGPSLNLPSILLNQPHLGWDQQQQQQQQQSPNVSTPPISTSPVLTGGQQVVNGISQISLLSPTQQINNPPSPVTQFNQASPQHNNNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNGSPQQPHVNNNNNNNIQQNKDHQFPVPTIPAKIIEVEKPFEWEVPLSEIAIGARIGRGGYGQVFRGSWRGTEVAVKMLFNDNVNLKLISDLRKEVDLLCKLRHPNIVLFMGACTEPSSPCIVTEYLSRGSLANILLDESIEMDWGLRLQLGFDCARGMTYLHSRNPIIIHRDLKTDNLLVDDSWQVKVADFGLATVKSHTFAKTMCGTTGWVAPEVLAEEGYTEKADVYSYAIVLWELLTRLIPYAGKNTMQVVRSIDRGERLPMPAWCPPKYAALMNRCWETDPTHRPSFPEILPIMEGMISEFQKEKKESIAQGRPIPYVGPPEKDPSNKQPPQNMATTIQQQLAQQQPQQLLEQQILLQVQQQAQLQHLQQQLEQQQKLQQQLQQQIAHPNNPNNFYFQQQLQQQQFQQQLQQHQQHFQQQQQQQQQQQQQQQQQQQQQQQQLQQTGSPIDNRLNYNFNNSNNSDIQPMQQENNYRMNINDKK
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) (P04843)
Organism: Homo sapiens (Human)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:E2RQ08}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:E2RQ08}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Protein transport protein Sec61 subunit alpha isoform 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
- Malectin
Sequence:
MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGGGSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDAL
Protein: Geranylfarnesyl diphosphate synthase (GFPS) (EC 2.5.1.81) (Farnesylgeranyl diphosphate synthase) (FGPP synthase) (Q3IPL1)
Organism: Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Function: Probably involved in biosynthesis of the precursor for C25 (sesterterpanyl chain) moiety of C20-C25 diether (2-O-sesterterpanyl-3-O-phytanyl-sn-glycer) membrane lipid. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylfarnesyl diphosphate (GFPP). Geranylgeranyl diphosphate (GGPP) is the preferred substrate, but dimethylallyl diphosphate (DMAPP) and farnesyl diphosphate (FPP) can also be used as allylic substrate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Tritrans,polycis-undecaprenyl-diphosphate synthase
- Tritrans,polycis-undecaprenyl-diphosphate synthase
- Ribonuclease J
- isopentenyl-diphosphate Delta-isomerase
- Phytoene synthase
- Bifunctional short chain isoprenyl diphosphate synthase
- Isopentenyl phosphate kinase
- Isopentenyl-diphosphate delta-isomerase
- Bifunctional short chain isoprenyl diphosphate synthase
- Large ribosomal subunit protein uL15
Sequence:
MTSADHVESAIAERREIVNEAVSEQLPVQKPERLYSASRYLLDAGGKRLRPTILLLAAESLADVEPLSADYRQFPSLPGDEVDVLSAAVSIEVIQSFTLIHDDIMDDDDLRRGVPAVHREYDLETAILAGDTLYSKAFEYMLDTGAPAERSVEALDELATTCTEICEGQALDVDFENRSDVTTEEYLEMVEFKTAVLYAAAASIPAILLGSDDETVEALHGYGLDIGRAFQIQDDLLDLTAPSDELGKQRGSDLVENKRTVITLHARDQGIDVEGLVSDDPSDAEIEAAVQTLEDAGSIDFAREMALDLVTSGKERLDVLPENEARQLLEDIADFLVERSY
Protein: Putrescine transport system permease protein PotI (P0AFL1)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex PotFGHI involved in putrescine uptake. Responsible for the translocation of the substrate across the membrane (Probable). Imports putrescine for maintenance of the optimal concentration of polyamines necessary for cell growth in the presence of glucose.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Spermidine/putrescine transport system permease protein PotB
- Putrescine-binding periplasmic protein PotF
- Putrescine transport system permease protein PotH
- Putrescine transport ATP-binding protein PotG
- Spermidine/putrescine import ATP-binding protein PotA
- Spermidine/putrescine-binding periplasmic protein
- Inner membrane ABC transporter permease protein YdcU
- sn-glycerol-3-phosphate import ATP-binding protein UgpC
- sn-glycerol-3-phosphate transport system permease protein UgpE
- sn-glycerol-3-phosphate transport system permease protein UgpA
Sequence:
MNNLPVVRSPWRIVILLLGFTFLYAPMLMLVIYSFNSSKLVTVWAGWSTRWYGELLRDDAMMSAVGLSLTIAACAATAAAILGTIAAVVLVRFGRFRGSNGFAFMITAPLVMPDVITGLSLLLLFVALAHAIGWPADRGMLTIWLAHVTFCTAYVAVVISSRLRELDRSIEEAAMDLGATPLKVFFVITLPMIMPAIISGWLLAFTLSLDDLVIASFVSGPGATTLPMLVFSSVRMGVNPEINALATLILGAVGIVGFIAWYLMARAEKQRIRDIQRARRG
Protein: Septin homolog spn3 (P48008)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:15385632, ECO:0000269|PubMed:28914606}. Note=Localizes to the medial ring at the cell cortex of dividing cells. {ECO:0000269|PubMed:15385632, ECO:0000269|PubMed:28914606}.
Interaction partners:
- Septin homolog spn4
- Septin homolog spn1
- Septin homolog spn2
- Septin homolog spn6
- Septin homolog spn5
- Septin homolog spn7
- Small ribosomal subunit protein eS32A
Sequence:
MRTTKKSSKKGIPLNLMVVGDVGLGRTAFINTLCEKPLIRHNNNFDPAEASSVSPVEIVPYQTDIILEDGTKINLTVLDTPHFGEAIDNENNFDIILQYIESQYDNVLEEESRIKRNARFCDDRVHALIYFISPTGHGLRELDIELMRRLAPRVNIIPAIAKADSLTAQELQTTKEMINADIEYYKIPVYDFPYDIEEDEEAIINLSQQLRATIPFAIVSSDRLIEMNGQTVRGRAYPWGVVEVDNPRHSDFLALRSALFATHIEDLHNITSNQLYETYRTEKLSTSQLLLDSTVGLDGKNLSQHDQVLREDRLRAIELSVQKEIEEKRRQLLAREEALRALEEKLAASTAAMANASVSTLPSSVSSTNHSQS
Protein: Anaphase-promoting complex subunit 11 (Q7KA43)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Shattered
- Anaphase-promoting complex subunit 2
- Polycomb group protein Psc
- Cyclosome subunit 8
- Fizzy-related protein homolog
- Ubiquitin-conjugating enzyme E2 C
- Anaphase-promoting complex subunit 5
- Polycomb group protein Pc
- Cell division cycle protein 20 homolog
- E3 ubiquitin-protein ligase RING1
Sequence:
MKVTIKSWTGVATWRWIANDENCGICRMSFESTCPECALPGDDCPLVWGVCSHCFHMHCIVKWLNLQPLNKQCPMCRQSWKFNVH
Protein: Interleukin 15 receptor subunit alpha (A0A8I5ZP92)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASPQLRGCGVHALPMLLPLLLLLLLLLPLRVTPGITCPTPISIEHADIRVKNYSVNSRERYVCNSGFKRKAGTSTLTECVINKNTNVAHWTTPNLKCIMAIPTSVLLVAAGIGLVFLTRYIKSRQASQPRRVEVETMETVPMTVRARSKEDEDHTTSETQGDQPTRGV
Protein: Transcriptional regulatory protein ChvI (P50350)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Function: Member of a two-component regulatory system ChvG(ExoS)/ChvI involved in regulating the production of succinoglycan.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MQTIALVDDDRNILTSVSIALEAEGYKVETYTDGASALEGLLARPPQLAIFDIKMPRMDGMELLRRLRQKSDLPVIFLTSKDEEIDELFGLKMGADDFITKPFSQRLLVERVKAILRRAANREAAAGGTGPAKNADTPSRSLERGQLVMDQERHTCTWKNESVTLTVTEFLILHALAQRPGVVKSRDALMDAAYDEQVYVDDRTIDSHIKRLRKKFKMVDNDFDMIETLYGVGYRFRETA
Protein: DEAD-box ATP-dependent RNA helicase 47, mitochondrial (EC 3.6.4.13) (Protein EMBRYO DEFECTIVE 1586) (Protein INCREASED SIZE EXCLUSION LIMIT 1) (Q8W4E1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis. Required for mitochondrial metabolism. Necessary for normal plasmodesmata (PD) development and aperture regulation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19805190}.
Interaction partners:
- DExH-box ATP-dependent RNA helicase DExH15 chloroplastic
- Protein DECREASED SIZE EXCLUSION LIMIT 1
- Regulator of nonsense transcripts 1 homolog
- GTP-binding protein At2g22870
- Pentatricopeptide repeat-containing protein At1g12300
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit I
- Probable elongation factor 1-gamma 2
- Pentatricopeptide repeat-containing protein At1g12620
- Eukaryotic translation initiation factor 3 subunit E
Sequence:
MAASTSTRFLVLLKDFSAFRKISWTCAATNFHRQSRFLCHVAKEDGSLTLASLDLGNKPRKFGKGKAMKLEGSFVTEMGQGKVRAVKNDKMKVVKEKKPAEIVSPLFSAKSFEELGLPDSLLDSLEREGFSVPTDVQSAAVPAIIKGHDAVIQSYTGSGKTLAYLLPILSEIGPLAEKSRSSHSENDKRTEIQAMIVAPSRELGMQIVREVEKLLGPVHRRMVQQLVGGANRMRQEEALKKNKPAIVVGTPGRIAEISKGGKLHTHGCRFLVLDEVDELLSFNFREDIHRILEHVGKRSGAGPKGEVDERANRQTILVSATVPFSVIRAAKSWSHEPVLVQANKVTPLDTVQPSAPVMSLTPTTSEADGQIQTTIQSLPPALKHYYCISKHQHKVDTLRRCVHALDAQSVIAFMNHSRQLKDVVYKLEARGMNSAEMHGDLGKLGRSTVLKKFKNGEIKVLVTNELSARGLDVAECDLVVNLELPTDAVHYAHRAGRTGRLGRKGTVVTVCEESQVFIVKKMEKQLGLPFLYCEFVDGELVVTEEDKAIIR
Protein: Uncharacterized protein (Q3U289)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLSRLSGLANNVLHELSGDYTDWNLMASSDADSSQETAMESNNRIMESTQEDALHRLAEAEKLVVELKDIISQKDVQLQQKDEALQEEKKAAENKIKKIKLHAKAKIMSLNKHMEEIKTQGGAALPPEAQAEELSKHNKSSTEEET
Protein: Gir2p (Q5AGV1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ribosome-interacting GTPase 2
- GTP-binding protein
- Translation machinery-associated protein 22
- Zinc finger CCCH domain-containing protein 15
- Gcn1p
- MAP kinase kinase kinase
- Elf1p
- Elongation factor 3
Sequence:
MDPIEEQAQEIEVLQSIYPDELTLINNTHFIIRIDLDTPSKRKHSLNLIVKYPPTYPEVIPQLSIELAESPEDKDNYDNGDSDEGDSDDDDDDDENADLKLALNMAETIEFDPKTDLNDTLMNKLLEESELNLGIPMIFNLITILKEESENLFNEKLNIKQCEFDEQQKIKELNEQKKFHGTKVTKQSWLNWRNNFRKEMKYELYDKQRFENMHKGKLTGKQIFEKGLANQNDDDEEEEGENQTIQEQEKDIVDGIKRL