wanglab/gogpt-training-data huggingface dataset:
Protein: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III) (P21217)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme.
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:1977660}. Note=Membrane-bound form in trans cisternae of Golgi.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
- Beta-1,3-galactosyltransferase 5
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
- Type 2 lactosamine alpha-2,3-sialyltransferase
- Beta-1,4-galactosyltransferase 1
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
- Beta-1,3-galactosyltransferase 1
Sequence:
MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLRTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADMVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT
Protein: p4c (Q8BDF8)
Organism: Vaccinia virus
Subcellular location: Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MANIINLWNGIVPTVQDVNVASITAFKSMIDETWDKKIEANTCISRKHRNIIHEVIRDFMKAYPKMDENRKSPLGAPMQWLTQYYILKNEYYKTMLAYDNGSLNTKFKTLNIYMITNVGQYILYIVFCIISGKNHDGTPYIYDSEITSNDKNFINERIKYACKQILHGQLTIALRIRNKFMFIGSPMYLWFNVNGSQVYHDIYDRNAGFHNKEIGRLLYAFMYYLSISGRFLNDFALLKFTYLGESWTFSLSVPEYILYGLGYSVFDTIEKFSNDAILVYIRTNNRNGYDYVEFNKKGIAKVTEDKPDNDKRIHAIRLINDSTDVQHIHFGFRNMVIIDNECANIQSSAENATDTGHHQDSKINIEVEDDVIDDDDYNPKPTPIPEPHPRPPFPRHEYHKRPKLLPVEEPDPVKKDADRIRLDNHILNTLDHNLNFIGHYCCDTAAVDRLEHHIETLGQYAVILARKINMQTLLFPWPLPTVHPHAIDGSIPPHGRSTIL
Protein: Putative uncharacterized protein ANKRD13C-DT (ANKRD13C divergent transcript) (HERV-H LTR-associating protein 3) (Human endogenous retrovirus-H long terminal repeat-associating protein 3) (Q9XRX5)
Organism: Homo sapiens (Human)
Interaction partners:
- HERV-H LTR-associating protein 2
Sequence:
MFGACYKQPLKPSGSEPPAEECRMTPRHAGCDVTEMQRILSQPTFTEHLLRAVCTKLANMYSTSTDCREHCRRGMKAKQLKAEAGRSCQRKGVPIQTPREHSWISCKKEFEANP
Protein: SLACS retrotransposable element (Part) (Q38C16)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MESLIKNIQSDLDLVRGALARAAFNQNPTSASKEGIGGESQEDAKSCQRSPQRGGDTVLVQPVDDREPEALAVASAAELSALREQVAALSAVELQRSKLEAQLAARDAALRHYTQSHLALSTKEQKQRRELEQTASTLKEAEAELVMWRERHQRLQREVQVLQHELEALAAQCDRLQSSVLELRELSRRAIDDNNALRKEKRELREECETLQSVRAALNDSVAREEALTQELQALRDASTESEAYFKAAVAEVEARRQYWAAVQGQHESLLEALALTQKTAQMWEDRFASECTPKVFGVNEVPADLPVDDFERPKEELLISTTEDGGSQREVNKGGDEAVDRESASLVAALEAKVVDLALHLQEQRAEAEAAKDAYNTLAAVVERESCDLLELRRKLAAQRPECMNLIDTNTRLQAALLARESYVEALQDFVVAILDDLTGLTFHCYELEVQLAISGAATPVTVSGDGREPVARRSTALNLIQSKQQRCQESWRITVPRGKRGSKGI
Protein: Acyl-CoA-binding domain-containing protein 2 (Acyl-CoA binding protein 2) (Q9STP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds medium- and long-chain acyl-CoA esters with very high affinity. Can interact in vitro with palmitoyl-CoA, but not with oleoyl-CoA. Binds to lead ions (Pb). May function as an intracellular carrier of acyl-CoA esters. Required for proper phospholipid and, to a lower extent, galactolipid composition.
Subcellular location: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Interaction partners:
- Ethylene-responsive transcription factor RAP2-12
- Heavy metal-associated isoprenylated plant protein 26
- Ankyrin
- Ethylene-responsive transcription factor RAP2-3
- Caffeoylshikimate esterase
- AT3G13950 protein
- Ankyrin repeat-containing protein BDA1
- Ethylene-responsive transcription factor RAP2-2
Sequence:
MGDWAQLAQSVILGLIFSYLLAKLISIVVTFKEDNLSLTRHPEESQLEIKPEGVDSRRLDSSCGGFGGEADSLVAEQGSSRSDSVAGDDSEEDDDWEGVESTELDEAFSAATLFVTTAAADRLSQKVPSDVQQQLYGLYKIATEGPCTAPQPSALKMTARAKWQAWQKLGAMPPEEAMEKYIEIVTQLYPTWLDGGVKAGSRGGDDAASNSRGTMGPVFSSLVYDEESENELKIDAIHGFAREGEVENLLKSIESGIPVNARDSEGRTPLHWAIDRGHLNIAKVLVDKNADVNAKDNEGQTPLHYAVVCDREAIAEFLVKQNANTAAKDEDGNSPLDLCESDWPWIRDSAKQAD
Protein: Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15) (O35468)
Organism: Mus musculus (Mouse)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:O14905}. Secreted {ECO:0000250|UniProtKB:O14905}.
Interaction partners:
- Protein-serine O-palmitoleoyltransferase porcupine
- Palmitoleoyl-protein carboxylesterase NOTUM
- Wnt inhibitory factor 1
- Glypican-3
- Cerberus
- Frizzled-4
- Frizzled-2
- Frizzled-5
- Low-density lipoprotein receptor-related protein 6
- Low-density lipoprotein receptor-related protein 5
Sequence:
MRPAPALALAALCLLVLPAAAAAAAYFGLTGREVLTPFPGLGTAAAPAQAGAHLKQCDLLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRQERWNCSLEGRTGLLQRGFKETAFLYAVSAAALTHALARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKGLAPRPGDLVYMEDSPSFCRPSKYSPGTAGRVCSRDSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCKR
Protein: Flagellar transcriptional regulator FlhC (P0ABY7)
Organism: Escherichia coli (strain K12)
Function: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Flagellar transcriptional regulator FlhD
- Motility protein B
- Motility protein A
- Chemotaxis protein CheA
- RNA polymerase sigma factor FliA
- Flagellin
- Flagellar protein FliL
- Flagellar biosynthesis protein FlhA
- Flagella basal body P-ring formation protein FlgA
- Chemotaxis protein CheW
Sequence:
MSEKSIVQEARDIQLAMELITLGARLQMLESETQLSRGRLIKLYKELRGSPPPKGMLPFSTDWFMTWEQNVHASMFCNAWQFLLKTGLCNGVDAVIKAYRLYLEQCPQAEEGPLLALTRAWTLVRFVESGLLQLSSCNCCGGNFITHAHQPVGSFACSLCQPPSRAVKRRKLSQNPADIIPQLLDEQRVQAV
Protein: tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase) (Q382R4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFDLMADACAAYMEDSEPTKARIEKNTEGEGRERKGRTSQCPKERCVRPKNNLAQGDKEFKEHKQRVMSNLSSNMCDHSPKGGVDRKCLKVMELLNNHQDYVTVSSCSGRIALFHSTPILETLHDSVNGSSSTKSAAVVGKRGSKDALGWLVVKHGELTEEEINQIVKGLCGDEAEDSSNTHSSPQVREVAERKFNGDEDELDGVWMQTGVLAPIPLPSFGTVTLKMEPFVMHVACRTMESGKRLLTAAATEAGFRNSGVTPPGKRVVCAIRNATGVGLDIPLVVDGVNYARGQHSYVRRLLLLANEKMRNNDLRRHRLEVGVAAFLERGHETPQCSHEERMRLPPPCVLGKHPDA
Protein: Metallo-beta-lactamase type 2 (EC 3.5.2.6) (B2 metallo-beta-lactamase) (Beta-lactamase II) (Carbapenem and cephamycin resistance) (CCRA) (Cephalosporinase) (Imipenem-cefoxitin hydrolyzing enzyme) (Metallo-beta-lactamase type II) (Penicillinase) (Zinc-requiring beta-lactamase) (P25910)
Organism: Bacteroides fragilis
Function: Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Subcellular location: Periplasm {ECO:0000269|PubMed:2110145}.
Interaction partners:
Sequence:
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYANQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVNQYIESTSKP
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (F4JNK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSIQHEIYFLHNEPHKYTRVFNLIFVITMDTHICIALISVTIILSLTVKTLSYQRMGCCCCLPSIPESSRTIDEHLPLSRATPSSLSNAYSSPLSPPIPLAITNINLQTSPPKLPRTQGNSSEASPGLTQVVPEKKTWHVDDLTDFELKKQYREAIDECPICLEEYEIDNPKLLTKCGHDFHLACILAWMERSEACPVCDKELVLTES
Protein: G-protein coupled receptors family 1 profile domain-containing protein (Serotonin receptor) (G5EGH0)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- G-protein coupled receptors family 1 profile domain-containing protein
- Serotonin-gated chloride channel mod-1
- G-protein coupled receptors family 1 profile domain-containing protein
- Transporter
- Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
- Dopamine receptor 3
- G-protein coupled receptors family 1 profile domain-containing protein
- GLutamate Receptor family
- GLutamate Receptor family
- Acetylcholine receptor subunit alpha-type acr-15
Sequence:
MIDETLLNLTASPSSQPATLLSAVARGTHLVDQFPAHAEIFSDIERPLVQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSITDICYVQNRTPKRITLMLAVIWFTSLLISLAPFAGWKDEGFSDRVLKSHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKKRFKRERDRRTVIRPPPDAIDEKKAMMPKKSKKCPLPPAVVISDIQANGGTGGKTNSIKNPPRHNESSSSASEEERTMTQTNHAPGDVTTQETKIDEENGRSKPGIVKRRRRTKESNEMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGCQISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRIIKRMCLIHDY
Protein: Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) (Q8IZ73)
Organism: Homo sapiens (Human)
Function: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.
Interaction partners:
- Pseudouridylate synthase 7 homolog
- Pseudouridylate synthase PUS7L
- Pseudouridylate synthase 1 homolog
- Pseudouridylate synthase TRUB1
- tRNA pseudouridine
- 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial
- rRNA methyltransferase 3, mitochondrial
- Pseudouridylate synthase TRUB2, mitochondrial
- tRNA pseudouridine synthase Pus10
- Mitochondrial mRNA pseudouridine synthase RPUSD3
Sequence:
MWLDRRGWLRVLGHWRYDLRRPSFTRTWSGDKGPMAETVSTQVGTEGGLRASHQQNGDAGGDAKVELSPGPPKPAGREVEPAPVGGEHPSAAAPGPGKHKKRRGATRERVVPPPKKRRTGVSFGDEHFAETSYYFEGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEAAVRAGRLQLNEKPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEEVTCKEPILVVSYKVGVCRVDPRGKPCETVFQRLSYNGQSSVVRCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQAKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIALASEKAVETDVMNQETDPLCAECRLVRQDPLPQDLVMFLHALRYKGPGFEYFSPMPAWAQDDWQKD
Protein: Protein E7 (P06788)
Organism: Human papillomavirus type 18
Function: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004}. Note=Predominantly found in the host nucleus. {ECO:0000255|HAMAP-Rule:MF_04004}.
Interaction partners:
Sequence:
MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
Protein: Small ribosomal subunit protein eS10B (40S ribosomal protein S10b) (Q9VWG3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein eS17
- GEO07453p1
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS7A
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS4
Sequence:
MFMPKAHRVAIYEYLFKEGVIVAKKDFHAQKHPELESIPNLHVIKAMQSLHSRGLVKEQFAWRHYYWYLTNEGIEELRSYLHLPPEIVPSTLKRPARSETVRPRPAVGGPRGPGDASKTGEDRSAYRRAPGGSGVDKKGDVGPGAGEVEFRGGFGRGSRN
Protein: MDIS1-interacting receptor like kinase 2 (AtMIK2) (Probable LRR receptor-like serine/threonine-protein kinase At4g08850) (EC 2.7.11.1) (Q8VZG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a receptor of SCOOP peptides from Brassicaceae plants regulating multiple processing including plant growth, development and stress responses. Perception of SCOOP peptides induces the association of MIK2 with the coreceptors BAK1/SERK3 and SERK4 and relays the signaling through the activation of receptor-like cytosolic kinases (RLCKs) BIK1 and PBL1. Also able to detect SCOOP-like proteins (SCOOPL) present in fungal Fusarium spp. and bacterial Comamonadaceae to elicit various immune responses, including growth inhibition, ROS production, calcium Ca(2+) influx, MAPK activation and MYB51 promoter activation in roots, thus being required for resistance to several root pathogens. Involved in the pollen tube perception of the female signal. Required to trigger defense responses toward generalist herbivores such as Spodoptera littoralis, probably via the activation of jasmonate and indole glucosinolate biosynthesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15308754, ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000269|PubMed:15308754, ECO:0000305|PubMed:17644812}.
Interaction partners:
- Protein MALE DISCOVERER 1
- Protein LURE 1.2
- Protein LURE 1.1
- Uncharacterized protein At3g28850
Sequence:
MNKTNPERKISLTSFKERMACKEKPRDLQVLLIISIVLSCSFAVSATVEEANALLKWKSTFTNQTSSSKLSSWVNPNTSSFCTSWYGVACSLGSIIRLNLTNTGIEGTFEDFPFSSLPNLTFVDLSMNRFSGTISPLWGRFSKLEYFDLSINQLVGEIPPELGDLSNLDTLHLVENKLNGSIPSEIGRLTKVTEIAIYDNLLTGPIPSSFGNLTKLVNLYLFINSLSGSIPSEIGNLPNLRELCLDRNNLTGKIPSSFGNLKNVTLLNMFENQLSGEIPPEIGNMTALDTLSLHTNKLTGPIPSTLGNIKTLAVLHLYLNQLNGSIPPELGEMESMIDLEISENKLTGPVPDSFGKLTALEWLFLRDNQLSGPIPPGIANSTELTVLQLDTNNFTGFLPDTICRGGKLENLTLDDNHFEGPVPKSLRDCKSLIRVRFKGNSFSGDISEAFGVYPTLNFIDLSNNNFHGQLSANWEQSQKLVAFILSNNSITGAIPPEIWNMTQLSQLDLSSNRITGELPESISNINRISKLQLNGNRLSGKIPSGIRLLTNLEYLDLSSNRFSSEIPPTLNNLPRLYYMNLSRNDLDQTIPEGLTKLSQLQMLDLSYNQLDGEISSQFRSLQNLERLDLSHNNLSGQIPPSFKDMLALTHVDVSHNNLQGPIPDNAAFRNAPPDAFEGNKDLCGSVNTTQGLKPCSITSSKKSHKDRNLIIYILVPIIGAIIILSVCAGIFICFRKRTKQIEEHTDSESGGETLSIFSFDGKVRYQEIIKATGEFDPKYLIGTGGHGKVYKAKLPNAIMAVKKLNETTDSSISNPSTKQEFLNEIRALTEIRHRNVVKLFGFCSHRRNTFLVYEYMERGSLRKVLENDDEAKKLDWGKRINVVKGVAHALSYMHHDRSPAIVHRDISSGNILLGEDYEAKISDFGTAKLLKPDSSNWSAVAGTYGYVAPELAYAMKVTEKCDVYSFGVLTLEVIKGEHPGDLVSTLSSSPPDATLSLKSISDHRLPEPTPEIKEEVLEILKVALLCLHSDPQARPTMLSISTAFS
Protein: Monothiol glutaredoxin-S1 (AtGrxS1) (Protein ROXY 16) (Q9SA68)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- U-box domain-containing protein 6
- At2g17660 family protein)
- Vacuolar iron transporter homolog 2.1
Sequence:
MEKISNLLEDKPVVIFSKTSCCMSHSIKSLISGYGANSTVYELDEMSNGPEIERALVELGCKPTVPAVFIGQELVGGANQLMSLQVRNQLASLLRRAGAIWI
Protein: T-cell leukemia homeobox protein 3 (Homeobox TLX-3) (Homeobox protein Hox-11L2) (Respiratory neuron homeobox protein) (O55144)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein lyl-1
- LIM homeobox transcription factor 1-beta
- T-cell acute lymphocytic leukemia protein 1 homolog
- Rhombotin-1
Sequence:
MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGAAYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV
Protein: Pre-rRNA-processing protein crb3/ipi3 (Q10272)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for both pre-rRNA processing and heterochromatic gene silencing.
Subcellular location: Nucleus {ECO:0000269|PubMed:21385875}. Chromosome {ECO:0000269|PubMed:21385875}.
Interaction partners:
- Pre-rRNA-processing protein ipi1
- Polynucleotide 5'-hydroxyl-kinase grc3
- Pre-rRNA-processing protein rix1
- Nucleolar GTP-binding protein 2
- Ribosome assembly protein 4
- Probable metalloprotease arx1
- Cell division control protein 18
- Cell division cycle protein cdt1
- DNA replication licensing factor mcm4
- Origin recognition complex subunit 2
Sequence:
MELLLSGCEAIEGEPSNVLCHNLHTGTLVSTFRQSSPAKNATCTTLNHLLSAQHTRPQLNIHNFGKEILDQSIILPEILICVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLVDQNSTFETSNSSVKAISHFSGHKRSIVSMEIGPGPIVSGRLYTASEDNTIRIWDVSTGNLLTTIALPSTPSCMTVDPSERVVYVGNEKGIIWIPLYTGSSTFSNNVKEKKRVTSVDNTTIPNAIGGMGRVVDYNDSRESSIISCQSPITTLTVSFDASLLISGDKDGNVLVWDSVSRQVLRRLVQYYSPVSFLQCKVDKISFYSNSSLSFPVLKRMITNEYLNSDVRICIQDDGVEQLMQPENILKISSDIVTQGSESSWRAKAETSEMQLKEAKRLFYELKQIHQALWEKYLQK
Protein: GATA-type domain-containing protein (D3YT69)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTPAATRSGSLWDSQSSLSQSGNSGDQWSPLFSPSTWSNNTNANPRLTSLTPLSSMNETLLSGVNYNSLLAMPPSAKNERSIGVQADDFLDRMSYNPIGRTGCTCQCQCGRGGAAIIGNTRGSSSRASGGSASPPSADGASQIDRFSPSNHAGSIGDRTLTAAALGVGLVDQQPAAPNHDGSANQPQRYYDPFGTADLLNGTRLNSLRIGN
Protein: IP20336p (TipE homolog 2, isoform B) (B6IDT8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP11896p
- RT03134p
Sequence:
MKKSSTLTTTTSMPASPTLSAQTLSASKISLNSSRCGSAGSGCGSASGSMRSACQSPVRPGSGCVDAIKAKREEIEMDTLLEKAKFYTSVCLGTTAILSVFTFLFLIPFVVDPAISTIIADYDPVPVTCIVIDHIYAEGIKNCSWSSCREGCTSSLTKCHQLFVNYTRIPFSEWERNPRDLDTVNWDVSYTKFLINSEGCGYPPTTNCSIFARQYGFSHIGEPFPCFYSRAYPEVVIGRYSWENNLYHLILSLIIPNVLFAISIGVLSYWYCPCCEKACNKSSRVYAEKFPTKEEIVNCMKCNTEKSLSLNVF
Protein: Methyltransferase type 12 domain-containing protein (I6X5U4)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Cyclo
- Conserved protein
- Secreted protein
- PPE family protein PPE10
- Ribonuclease VapC24
- Isoniazid-induced protein IniB
- Probable membrane protein
- PPE family protein PPE55
- Uncharacterized protein Rv2209
Sequence:
MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHLSRPAEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPSQAITGTGCRPSRVWVMNRLREKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVFVASRAPLNLPTLVEELPMVQRRC
Protein: Dynein light chain Tctex-type 1 (Activator of G-protein signaling 2) (AGS2) (T-complex testis-specific protein 1) (TCTEX-1) (P51807)
Organism: Mus musculus (Mouse)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility.
Subcellular location: Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to mitotic spindles. {ECO:0000250}.
Interaction partners:
- Dynein light chain
- Dynein light chain roadblock-type 1
- Cytoplasmic dynein 1 intermediate chain 1
- Dynein light chain 2, cytoplasmic
- Dynein light chain roadblock-type 2
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynein light chain 1, cytoplasmic
- Cytoplasmic dynein 1 heavy chain 1
- Dynein light chain Tctex-type 2A1
- Dynein light chain Tctex-type protein 2
Sequence:
MEDFQASEETAFVVDEVSSIVKEAIESAIGGNAYQHSKVNQWTTNVLEQTLSQLTKLGRPFKYIVTCVIMQKNGAGLHSASSCFWDSSTDGSCTVRWENKTMYCIVSTFGLSI
Protein: Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) (Protein EMeg32) (Q9JK38)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:10777580}; Peripheral membrane protein {ECO:0000269|PubMed:10777580}. Endosome membrane {ECO:0000269|PubMed:10777580}; Peripheral membrane protein {ECO:0000269|PubMed:10777580}.
Interaction partners:
- Phosphoacetylglucosamine mutase
- Glutamine--fructose-6-phosphate aminotransferase 1
- N-acetyl-D-glucosamine kinase
- Glucosamine-6-phosphate deaminase 1
- Glutamine--fructose-6-phosphate aminotransferase 2
- Glucosamine-6-phosphate deaminase 2
- Hexokinase-1
- Hexokinase HKDC1
- Hexokinase-3
- Hexokinase-2
Sequence:
MKPDETPMFDPSLLKEVDWSQNTAIFSPAISPTHPGEGLVLRPLCTADLNKGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFDYTVSEENYMCRRFLK