wanglab/gogpt-training-data huggingface dataset:
Protein: ER membrane protein complex subunit 1 (O13981)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (By similarity). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P25574}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25574}.
Interaction partners:
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 4
- TPR repeat protein oca3
- UPF0620 protein C83.10
- ER membrane protein complex subunit 5
- Uncharacterized membrane protein C660.17c
Sequence:
MLRPLWPLFLTALFLNIYRAASVLIDEAGKNDFEISLLGKVNDLVYDTKNEYLYAVSQKGLLAKLNASNGDVIWRQSIAPETSQLNYNPVTNFIITVDKDYLYIWNSKNGILDRKIELADGKGKLFEVNKGFVYLNPHTRKFIELDLQASFSISIERDLQLDAISFLTYAEKNYVLFKRDGQFVLQALDHNYAVYGPETVLNVPENAQLLVTEKDVIIYSSNGVIYGIHVSMADISQLLIDEYKTFEWSSIPGKRHGYSITVDSQSTPVTYLFVIIDSEFVLIDEYIHEDTEALGYIHMEDNQTFSRVFAVANQIKFAPATVITIPNQLSRPVFRLFTFAEGEISAIVILDDGTFFSFSNTELVWKREEALAYAINPSILPTTLLTSYQKSIQDEENSSVSFLNRWYRHFNQLIDFLKHPHGFTSSSVLDDAFTTKIIIPTSTGSIFCLSSDPKQVHRILWRYDFNINPESVESWLLDISDEDPKFAFVHQWNDAFSFYILNASDGSVISQKSRDFKADEFYYVDNISKNLPNQIFAVKDYKVLPLTGDNSIFEKISQEANSIFVYTSETKVEGFSISADLTMDVQWSYNLAEGEIVIASIRRNPHEIVASFGRVLQNREVMYKYLNPNLFALFSKCKNDLVVYVMDSVTGSIVYQNKHQGIILFDKVYGVFSENWLVYSYQSDVPNLSTKIISVELFEGSHSNEKIDSNEIYSRHNDYRPYAFTKAYIFDREITTLGVTNTPQGITSRDVLLGLSSNQVAMIPQALLSPMRPVLRPNEKANDASFIPYEPIIPLNDDMVLSYNKRVYGVSQITSGITNFESTTLVLSTGLDVFFTRTAPSMPYDMLSSHFDKKQLMLTTFGILLAVLLTKPLVKKKQLNTKWYN
Protein: Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Eukaryotic translation initiation factor 3 subunit 5) (Q18967)
Organism: Caenorhabditis elegans
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit E
- COP9/Signalosome and eIF3 complex-shared subunit 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit G
Sequence:
MASNLTVNVHPGVYMNVVDTHMRRTKSSAKNTGQEKCMGTLMGYYEKGSIQVTNCFAIPFNESNDDLEIDDQFNQQMISALKKTSPNEQPVGWFLTTSDITSSCLIYHDYYVRVITEASARRESPPIVVLTIDTTFSGDMSKRMPVRAYLRSKAGIPGAAGPHCAIFNPLRVELAAFPGELVAMQLIEKALDSRRREATLESGLEQLETSTAQMIEWLERMLHYVEDVNKNGEKPGDAQIGRQLMDIVTASSNNMQPEKLDTLVKNTLRDYVMVSYLAKLTQTQLQVHERLVSA
Protein: LD39385p (Q8MR19)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
KPVGGLPETATEQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRASDKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERTRALDHGYKEAREFNDAWSGMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQSVYDGTMRTGKNLLERAPKGDRPVLDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNENGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLKTGRDLERSGNNPEVGRQLDEMQSIWEEVKSAVAKRGERLQVALVDAEKLNARVQALFDWLDHAEHKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLSIIQQRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKLIEDHKEFMENTARRQNEVDRACKPRQLPPGARKPSRSGKTPVRGSSHDLREQSPDGTLRRQSFKGSRDQGLNARKGSRITPTRDTPDRDRLPHYGPRFSPSTSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLLYLKDVERARNFSWDDWRKRFLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKPANDSDKIHDEVKRLVMLCTCRQKFRVFQVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEFLQKNDPCRAKGRTNIELREQFILADGVSQSMAAFTPRRSTPNAAATASSSPHAHNGGSSNLPPYMSGQGPIIKVRERSVRSIPMSRPSRSSLSASTPDSLSDNEGSHGGPSGRYTPRKVTYTSTRTGLTPGGSRAGSKPNSRPLSRQGSKPPSRHGSTLSLDSTDDHTPSRIPQRKPSTGSTASGTTPRPARLSVTTTTTPGSRLNGTSTITRKTASGSASPAPTRRNISGSSTPSGMQTPRKSSAEPTFSSTMRRTSRGTTPTEKREPFRL
Protein: Protein NIM1-INTERACTING 3 (Protein NIMIN-3) (Q9FNZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:11442055}.
Interaction partners:
- Regulatory protein NPR1
- Protein NIM1-INTERACTING 2
- Protein NIM1-INTERACTING 1
- At4g01895
- Putative metallothionein-like protein 1B
- Metallothionein-like protein 1C
- Transcription factor TGA2
Sequence:
MDRDRKRVKMEKEDDEEEKMEKLYTVLKNAREMRKYVNSSMEKKRQEEEERARVRRFPSFQPEDFIFMNKAEANNIEKAANESSSASNEYDGSKEKQEGSETNVCLDLNLSL
Protein: Trafficking protein particle complex subunit 2 (F5H785)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
Sequence:
MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKVWYVL
Protein: NK2 homeobox 2 (D3ZDQ2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Transducin-like enhancer protein 3
- Oligodendrocyte transcription factor 2
- Neurogenin 3
- Hepatocyte nuclear factor 3-beta
- Paired box protein Pax-6
- DNA
- Achaete-scute homolog 1
- Neurogenic differentiation factor 1
- Paired box protein Pax-4
- Insulin gene enhancer protein ISL-1
Sequence:
MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQSALDAVQSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSKSPEPSADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
Protein: Complement receptor type 2 (Cr2) (Complement C3d receptor) (CD antigen CD21) (P19070)
Organism: Mus musculus (Mouse)
Function: Receptor for complement C3d and for HNRNPU. Participates in B lymphocytes activation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20023}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20023}.
Interaction partners:
- B-lymphocyte antigen CD19
- CD81 antigen
- Complement C4-B
- Complement C3
- Interferon-induced transmembrane protein 3
- Low affinity immunoglobulin epsilon Fc receptor
- B-cell receptor CD22
- B-cell antigen receptor complex-associated protein alpha chain
- Receptor-type tyrosine-protein phosphatase C
- Complement component C1q receptor
Sequence:
MLTWFLFYFSEISCDPPPEVKNARKPYYSLPIVPGTVLRYTCSPSYRLIGEKAIFCISENQVHATWDKAPPICESVNKTISCSDPIVPGGFMNKGSKAPFRHGDSVTFTCKANFTMKGSKTVWCQANEMWGPTALPVCESDFPLECPSLPTIHNGHHTGQHVDQFVAGLSVTYSCEPGYLLTGKKTIKCLSSGDWDGVIPTCKEAQCEHPGKFPNGQVKEPLSLQVGTTVYFSCNEGYQLQGQPSSQCVIVEQKAIWTKKPVCKEILCPPPPPVRNGSHTGSFSENVPYGSTVTYTCDPSPEKGVSFTLIGEKTINCTTGSQKTGIWSGPAPYCVLSTSAVLCLQPKIKRGQILSILKDSYSYNDTVAFSCEPGFTLKGNRSIRCNAHGTWEPPVPVCEKGCQAPPKIINGQKEDSYLLNFDPGTSIRYSCDPGYLLVGEDTIHCTPEGKWTPITPQCTVAECKPVGPHLFKRPQNQFIRTAVNSSCDEGFQLSESAYQLCQGTIPWFIEIRLCKEITCPPPPVIHNGTHTWSSSEDVPYGTVVTYMCYPGPEEGVKFKLIGEQTIHCTSDSRGRGSWSSPAPLCKLSLPAVQCTDVHVENGVKLTDNKAPYFYNDSVMFKCDDGYILSGSSQIRCKANNTWDPEKPLCKKEGCEPMRVHGLPDDSHIKLVKRTCQNGYQLTGYTYEKCQNAENGTWFKKIEVCTVILCQPPPKIANGGHTGMMAKHFLYGNEVSYECDEGFYLLGEKSLQCVNDSKGHGSWSGPPPQCLQSSPLTHCPDPEVKHGYKLNKTHSAFSHNDIVHFVCNQGFIMNGSHLIRCHTNNTWLPGVPTCIRKASLGCQSPSTIPNGNHTGGSIARFPPGMSVMYSCYQGFLMAGEARLICTHEGTWSQPPPFCKEVNCSFPEDTNGIQKGFQPGKTYRFGATVTLECEDGYTLEGSPQSQCQDDSQWNPPLALCKYRRWSTIPLICGISVGSALIILMSVGFCMILKHRESNYYTKTRPKEGALHLETREVYSIDPYNPAS
Protein: Probable prefoldin subunit 4 (Q9UTD4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Interaction partners:
- Probable prefoldin subunit 2
- Probable prefoldin subunit 5
- Probable prefoldin subunit 1
- Probable prefoldin subunit 3
- Probable prefoldin subunit 6
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- Probable T-complex protein 1 subunit eta
- T-complex protein 1 subunit epsilon
- Probable T-complex protein 1 subunit beta
Sequence:
MEQVPVLAEDQRNLNEFSVLHSRKAIQELDIKNLKTQIEDIVDAKNECELLDEDDGDDIPALKVGDAFFQVSLPVLLDQLEQSEESLEKQVDVLRSSMEKDETRIQELKSMLYSKFHDQINLD
Protein: At3g27250 (Q9LK28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDQDDWLGTLRYAGKAQDKVSVDALMLRYRPIAPKPTTGQPCGVADNNNNSSYGMSKRTKRKYVRVSKNNKGTCRGKSRSDLSDDREQTDVVTLQLLPEKSDISGEYSPLDQDSLDPSVKSIIGEETQETNTWGMFNGSVTAEMETWVTVESVTSVCEGSLSSHAVGITDVEIVDNLGKDTCPAFVSDGSNRVVWVNEAYRRNVSGDDSTASVSPEVVVWLVAEEATAAMHCNYQAFTCRVRMQYTWKETKYTKTVPCDVWKMEFGGFAWRLDTTAALTLWL
Protein: MEQ (Q6USD0)
Organism: Gallid alphaherpesvirus 2
Interaction partners:
Sequence:
MSQEPEPGAMPYSPADDPSPLDLSLGSTSRRKKRKSHDIPNSPSKHPFPDGLSEEEKQKLERRRKRNRDAARRRRRKQTDYVDKLHEACEELQRANEHLRKEIRDLRTECTSLRVQLACHEPVCPMAVPLTVTLGLLTTPHDPVPEPPICTPPPPSPDEPNAPHCSGSQPPICTPPPPDTEELCAQLCSTPPPPISTPHIIYAPGPSPLQPPICTPAPPDAEELCAQLCSTPPPPICTPHSLFCPPQPPSPEGIFPALCPVTEPCTPPSPGTVYAQLCPVGQVPLFTPSPPHPAPEPERLYARLTEDPEQDSLYSGQIYTQFPSDTQSTVWWFPGDGRP
Protein: Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) (Q9H497)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm. Endoplasmic reticulum lumen.
Interaction partners:
- Torsin-1A-interacting protein 1
Sequence:
MLRGPWRQLWLFFLLLLPGAPEPRGASRPWEGTDEPGSAWAWPGFQRLQEQLRAAGALSKRYWTLFSCQVWPDDCDEDEEAATGPLGWRLPLLGQRYLDLLTTWYCSFKDCCPRGDCRISNNFTGLEWDLNVRLHGQHLVQQLVLRTVRGYLETPQPEKALALSFHGWSGTGKNFVARMLVENLYRDGLMSDCVRMFIATFHFPHPKYVDLYKEQLMSQIRETQQLCHQTLFIFDEAEKLHPGLLEVLGPHLERRAPEGHRAESPWTIFLFLSNLRGDIINEVVLKLLKAGWSREEITMEHLEPHLQAEIVETIDNGFGHSRLVKENLIDYFIPFLPLEYRHVRLCARDAFLSQELLYKEETLDEIAQMMVYVPKEEQLFSSQGCKSISQRINYFLS
Protein: E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (mLin41) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) (Q1PSW8)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity).
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:19898466, ECO:0000269|PubMed:22508726, ECO:0000269|PubMed:22735451}.
Interaction partners:
- Protein argonaute-2
- Protein lin-28 homolog A
Sequence:
MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATAEEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLMRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPPDQALYLALKSIGFVSSGAFAPLTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDGEGKLCRPWGVSVDKEGFIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIIVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVVDFGNNRILIF
Protein: Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (P16617)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00558}. Mitochondrion matrix {ECO:0000250|UniProtKB:P00558}. Note=Hypoxic conditions promote mitochondrial targeting. Targeted to the mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA mcPGK1. {ECO:0000250|UniProtKB:P00558}.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Phosphoglycerate mutase 1
- Phosphoglycerate mutase 2
- glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Triosephosphate isomerase
- Triosephosphate isomerase.
- Glucose-6-phosphate isomerase
Sequence:
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGSEVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMAKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTESSKKYAEAVARAKQIVWNGPVGVFEWEAFARGTKSLMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNV
Protein: Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide] (P20068)
Organism: Rattus norvegicus (Rat)
Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.
Interaction partners:
- Neurotensin receptor type 1
- Neurotensin receptor type 2
- Sortilin
- Neurolysin, mitochondrial
- Protachykinin-1
- Somatostatin
- Galanin peptides
- Cholecystokinin
- Gastrin-releasing peptide
- Kininogen-1
Sequence:
MIGMNLQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHASKVSKGSPPSWKMTLLNVCSLINNLNSAAEEAGEMRDDDLVAKRKLPLVLDDFSLEALLTVFQLQKICRSRAFQHWEIIQEDILDHGNEKTEKEEVIKRKIPYILKRQLYENKPRRPYILKRASYYY
Protein: AT-rich interaction domain 1B (A0A1B0GTJ8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAARAAAAAAAAAARARARAGSGERRAPPGPRPAPGARDLEAGARGAAAAAAAPGPMLGGGGDGGGGLNSVHHHPLLPRHELNMAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
Protein: Transcription cofactor vestigial-like protein 3 (Vgl-3) (P85442)
Organism: Mus musculus (Mouse)
Function: May act as a specific coactivator for the mammalian TEFs.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8N8G2}.
Interaction partners:
Sequence:
MSCAEVMYHPQPYGAPQYLPNPVAAATCPTACYHPAPQPGQQKKLAVYSKMQDSLEVTLPSKQEEEEEEEEDEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQANTLHPESAISKSKMGLTPLWRDSSALSSQRSNFPTSFWTSSYQPPPAPCLGGVHPDFQVTAPHGTFTTADPNSWPGHGLHQTGPAPPPTASESWHYPLASQVSPSYSHMHDMYLRHHHPHAHVHHRHHHHHHPTAGSALDPAYGHLLMPSVRAARIPAPQCDITKTDLTTVTTATSAWAGAFHGTVDIVPSVGFDTGLQHQDKSKESTWY
Protein: Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Q9Z2X8)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15367669, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:17903176, ECO:0000269|PubMed:27697860}. Nucleus {ECO:0000269|PubMed:15379550}. Note=Mainly cytoplasmic (PubMed:17903176). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20173742, PubMed:20421418, PubMed:20495340). {ECO:0000269|PubMed:17903176, ECO:0000269|PubMed:20173742, ECO:0000269|PubMed:20421418, ECO:0000269|PubMed:20495340}.
Interaction partners:
- Cullin-3
- Nuclear factor erythroid 2-related factor 2
- Sequestosome-1
- E3 ubiquitin-protein ligase RBX1
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- Endonuclease 8-like 2 lyase Neil2)
- Prothymosin alpha
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Partner and localizer of BRCA2
- Dipeptidyl peptidase 3
Sequence:
MQPEPKLSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
Protein: Arrestin-C (Cone arrestin) (cArr) (Retinal cone arrestin-3) (P36576)
Organism: Rattus norvegicus (Rat)
Function: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.
Subcellular location: Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9EQP6}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9EQP6}.
Interaction partners:
- Rhodopsin
- Short-wave-sensitive opsin 1
- Recoverin
- Medium-wave-sensitive opsin 1
- Clathrin heavy chain 1
- Phosphodiesterase
- Photoreceptor-specific nuclear receptor
- Cone-rod homeobox protein
- G protein subunit alpha transducin 2
- Cyclic nucleotide-gated channel subunit beta 1.
Sequence:
LKHEDTNLASSTILRPGMNKELLGILVSYKVKVNLMVSYGGILGGLPASDVGVELPLILIHPKPPHGERAVATSSEDIVVEEFTQQNSQTQS
Protein: Hnrpr protein (Q99KG1)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
SFSKRLALLLTGQAASPPLCPGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAYEDYYYHPPPRMPPPMRGRGRGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQQQRGRGSRGARGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK