Protein: ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) (Q9ESR9)
Organism: Rattus norvegicus (Rat)
Function: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. May play a role in myelination, perhaps as a transporter for certain kinds of myelin chemical components. May play an important role in gamma-secretase processing of APP and thus in amyloid-beta peptide generation. Regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism.
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q9BZC7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BZC7}. Lysosome membrane {ECO:0000269|PubMed:11157071, ECO:0000269|PubMed:12210128}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BZC7}. Note=Forms discrete, punctate intracellular vesicles. {ECO:0000250|UniProtKB:Q9BZC7}.
Interaction partners:
Sequence:
MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEAFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLNRVVEESNLFDPERPSLGSELEALHQRLEALSSGPGTWESHSARPAVSSFSLDSVARDKRELWRFLMQNLSLPNSTAQALLAARVDPSEVYRLLFGPLPDLDGKLGFLRKQEPWSHLGSNPLFQMEELLLAPALLEQLTCAPGSGELGRILTMPEGHQVDLQGYRDAVCSGQATARAQHFSDLATELRNQLDIAKIAQQLGFNVPNGSDPQPQAPSPQSLQALLGDLLDVQKVLQDVDVLSALALLLPQGACAGRAPAPQAGSPSGPANSTGVGANTGPNTTVEEGTQSPVTPASPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEADHVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLHWLQQYVADLRLHPEAMNLSLDELPPALRLDYFSLPNGTALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMIERAIINTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVLIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTETWEWSWPWAHAPRLSVMEEDQACAMESRHFEETRGMEEEPTHLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSMAQEEIRKEMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPSGRPQLSNCSEMQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQASLQSASSVGSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGWWLKMRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNTSLPPTAGPETWTWAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNIQKSIPAPIGTRTPLMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEIAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTIMCQYNFLRQPQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKLELTKCADKPAGSYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYSVSQTTLDNVFVNFAKKQSDNVEQQEAEPSTLPSPLGLLSLLRPRPAPTELRALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC