wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclo(L-leucyl-L-leucyl) synthase (EC 2.3.2.22) (Cyclodileucine synthase) (Cyclodipeptide synthase) (CDPS) (Q65EX3)
Organism: Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)
Function: Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L-phenylalanine, L-leucine and methionine, into cyclodipeptides.
Interaction partners:
- Cytochrome P450-like enzyme CypX
- Sigma-E controlled sporulation protein
- Putative cellulose synthase
- Pectin lyase-like protein
- Hypothetical phage related protein
- Putative permease YtrC
- YdaL
- YvfB
- Response regulator aspartate phosphatase
- TuaE
Sequence:
MTELIMESKHQLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHTFSDFANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEYVIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEADERVESKSMQEERV
Protein: Ankyrin repeat domain-containing protein 1 (A0A384NYH5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF
Protein: Forked, isoform C (Q86B49)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, stereocilium {ECO:0000256|ARBA:ARBA00004645}.
Interaction partners:
Sequence:
MTTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVHSSSTGSEIGDGGQGNTSLIEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGDQDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLYVRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAKLSLDKYGKSPINDAAENQQVECLNVLVQHGTSVDYNGKSSSQRHKSQQQLHQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAGGSGGSGMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEKLYNGSSSLGGNPGGNSSSGGGGVGGGGGSGGALLPNDGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQDIIYNRVRDLFVDSDCSSSVKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSGAGSGSDESVSISSSFNSPKQQQQLRSQSFNRHGSSSNISASGNIKNNNYKAHKGKPSNQNGGGDHDYEDIYLVREESRKQHQQQQQHQLQQQQQLQHQATQQQQQQQQQQQQLQHKYNVGRSRSRDSGSHSRSASASSTRSTDIVLQYSNHHLNNKRNMNNNSNMNNSSSNIAQSSSSNNNNNSLLNRNKSHSIIGLHSSKYESSLKDNYSAKNVNLKNQLLNGGIKSDTYESVCPPEDVAERTKQTHKNSMIRNNLADASSNNNTSGSINNISNIGNMNGGNQSSRNLKRVSSAPPMQNLAVVNGPPPPPLPPPLRAPVQQQRNNLSVDQPNSMTGNNGIYKKNVFGPNQGPTNANGTGGAAPPPVPAPNPVATEAVDSDSGLEVVEEPSLRPSELVRGNHNRTMSTISANKKAKLLNAGSTNGSSIAASSDDSQSRYGGSVHAANGSAANGHFYGYSEGNKNQGSNGNGNGNGNGGGGNYHSHPNQPHYATGQPHQYTPSLYGGGSSAEDHYELTQQQQQIYGETHLPSGQRTGGPNLVNKQLVLPFVPPSFPNKSQDGVTHLIKPSEYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQPPLPPPPPPLPHGMLPPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGSAPNSQDTATRKQHQPLSAISIQDLNSVQLRRTDTQKVPKPYQMPARSLSMQCLTSSTETYLKSDLIAELKISKDIPGIKKMKVEQQMASRMDSEHYMEITKQFSGNNYVDQIYLQIPERDQAGNAIPDWKRQMMAKKAAERAKKDFEERMAQEAESRRLSQIPQWKRDLLARREETENKLKAAIYTPKVEENNRVADTWRLKNRAMSIDNININLAGMEQHYQQIQFQQKQQQLQLGNKENHVDPKGADQDQEHGVGIGSGVGNANSGVIGGQELIDPSEGSQGRAEEEEDNIIPWRAQLRKTNSRLSLI
Protein: Transmembrane protein 50A (Small membrane protein 1) (O95807)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Blood group Rh
- Leptin receptor gene-related protein
- Leptin receptor overlapping transcript-like 1
Sequence:
MSGFLEGLRCSECIDWGEKRNTIASIAAGVLFFTGWWIIIDAAVIYPTMKDFNHSYHACGVIATIAFLMINAVSNGQVRGDSYSEGCLGQTGARIWLFVGFMLAFGSLIASMWILFGGYVAKEKDIVYPGIAVFFQNAFIFFGGLVFKFGRTEDLWQ
Protein: Tetraspanin 26A, isoform B (Q9VMJ6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPAAVRKFRRETSEISCCLKYLLFASNVILWLSALLVLSVGIWAWSEKGMFRNIARLHFIALDPAFVLIILGGVTFLLGFMGSVGALRENTCLLGAYAIFLSVLLIAEIGFCAVAFVLKDKGWIKDQATEGLKAFIRHYREDADQQNLIDWIQEDWLQCCGIDGPKDWDSNNYFNCSSIAIGSREACGVPFSCCRRRPQEVIKNKQCGYDVRKEGYPVDRNIHERGCLRAGEDWLEAHLISVAIGCVALLVLQGMELSKIIYEKGCVQAGEEWMEHNLIIISATVIVVMFFQILGICFAQNLRADIYTQKSKWH
Protein: Nicotinic acetylcholine receptor Dalpha6 subunit variant type V (Q8T7R9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKMDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ
Protein: Alcohol dehydrogenase-like protein (NAD(P)-binding Rossmann-fold superfamily protein) (Putative short chain alcohol dehydrogenase) (Q9LW35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Remorin family protein
- TORTIFOLIA1-like protein 3
- F16N3.9 protein
- S-protein homolog
- WD40 domain-containing protein
- PAR1 protein
- Remorin 4.2
- Carbohydrate-binding X8 domain-containing protein
- NAD
- Eukaryotic aspartyl protease family protein
Sequence:
MWRSFARSFKLINVPNGLISKPIRSTLLYSTSSRKLEGKVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATELGSAAHFLRCDVTEEEQIAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNVRGTVLGIKHAARAMIPAGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVVKTVASELCKHGLRINCISPAGIPTPLTLRMFREAFAGHSIREEQLLAIVNATGELKGEKCEEIDVAKAALYLASDDAKFVTGHNLVVDGGFTCFKSLNLPSA
Protein: EGF-like-domain, multiple 7 (Epidermal growth factor-like protein 7 isoform X1) (Epidermal growth factor-like protein 7 precursor) (Zgc:136669) (Q1RLZ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Sprouty-related EVH1 domain-containing 1.
- Phosphatidylinositol 3-kinase regulatory subunit beta)
- Epidermal growth factor.
Sequence:
MYTALLLSSSLFLLHVTSTPQTHSHHGRRVCVGDVWSRRVSYSTESFLQPVHKPYITMCQNHRMCSTYKTIYKVSYRQVSRAAPNLQIYPECCPGWRRMHSHNCNQAVCEQSCANGGSCVRPNHCACLRGWTGRFCQIDVDECKEAQSCSQKCVNTLGSFQCVCEEGFSLDEDKVTCSKNPASSRNTGGGLGLVENVTEEVQILKNRVELLEQKLEMVLAPFTTLLPLDGAGDTNSFLSERTNFLSHSLQQLDRIESLSEQVGFLEERIGACGCQEN
Protein: GDT1-like protein C17G8.08c (Q10320)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKNPIKWAIIAVLLSTVVAKKIVGEGMADVSAIKHPEEVHPTNRDFLRSLIFSISMIFGCEIGDKTFIVAALLAFENSRLTVFAGSYSALFIMTLLGVLLGHAAPLLFPRKLTDILGGVLFVIFGIKMLMEAKEVMDSKESMSDEFQNVRNEIAANGPIDQLLEEGAAPSHYTGHRSRSGHTLMSQLKSKGRNVMATLFSPLFIKAFALTFVSEWGDRSQIATIAMAASDNVYGVFMGANVGHACCTALAVISGKYISTKIKVHKVMFIGGILFIAFGLVYFYQGFF
Protein: Neuralized E3 ubiquitin protein ligase 1 (D3ZZE6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGSSFPVPSHRCHHKQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLGTQTLHTGRASSSLSFLIWKMGHG
Protein: Mbd2 protein (B0BNM2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAARGGGVCGRGRGRGRGRGRGRGRGRGRGRPQSGVSGLGGDGGAGGCGVGSSGGVAPRRDPVPFPSGSSGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPNNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDDDIRKQEERVQQVRKKLEEALMADILSRAVDTEEVDIDMDSGDEE
Protein: RE34668p (Q8MKL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MELSLFTLNLFDVVSVVLTFLVIFLVQILNVYLHILDDNADNGKSIDVVDKAPAKECPLLESQSPSSPIATTLPKSQASSNGKLEKQISLLDSDSHEDEDTLSLENLFPCDQTEIYASKKISFIIDELIQTEVNYVNNLKKGMLNYGQLKDVEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSFTMGKKSSMQLRQDNRLWLQTYQTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYKSGISCKPVLTAVCKLETRMRRALDVVNQAEEIPNIEELNELDVLQLGNFRRATEFDAQHFPTRKKYRSKVFLFDRCLVCTEVRKKRLAYRQHYNWEHVELQRPLDSVSSNANKIINLLVKQEEGGSSVGSKREEYSFMAAEASVVKQWLQATHKIIEIARNEHARRNTFSLPMDLVLGVVLAIWLIWQYL
Protein: 8-amino-7-oxononanoate synthase (At3g09050) (MZB10.8 protein) (Q9SS82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMNTLHAFQTTLTPNFHVLFNASRHSLSRPQFLCLSKSGDGTSDSDSDPDPPKPEGDTRRQELLARIAMIQTSKVRLTDFLDERSEYLTKFAEEANAEFDKVGEDAMKDLDEASTRILENIESKMQAFEESAGLNRLEIEENDNKLAEFEEKIQVDRNEGLFFKSLRDKKPVDREQAREETEKIQEVTKESAGSKSRRNIYLGLIGIVVLAIADSFVSSPDWRKVAILGAILVPLLTQFVYEQTLLSEADKGKENKKE
Protein: Gap junction protein (Q8JFD6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
- Tight junction protein 1a
- Cyclin-dependent kinase 1
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Neurobeachin b.
- Neurobeachin
- Tight junction protein 1b
- Gap junction alpha-1 protein
Sequence:
MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQSMFVCNTLQPGCNQACYDKAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQKERRYSTIYLSLDKDPDTMRRDDSKKIKNTIVNGVLQNTENSTKESEPDCLEVKEIPNSAMRTTKSKMRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFNVPAVYECDRYPCIKDVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKTAVRGVQARRKSIYEIRNKDLPRMSMPNFGRTQSSDSAYV
Protein: Rac GTPase-activating protein 1 (Q9XUS9)
Organism: Caenorhabditis elegans
Interaction partners:
- Kinesin-like protein
- Protein ECT2
- Protein regulator of cytokinesis 1
- Anillin-like protein 1
- Kinesin-like protein
- Ras-like GTP-binding protein rhoA
- Anillin-like protein 2
- Kinesin-like protein klp-19
- Aurora/IPL1-related protein kinase 2
- Incenp-like protein ICP-1
Sequence:
MKSSTSKEKVCGENSRHIFNMILNSQRPQFDIKDIGMFHLIDEIERLRKLWKDSEESKKRLNADMREAEEALAKARKKLAMFDIDVKDTQKHLRALMEENKALKLDLNVYETREKQLKDAMKNGIFNSLTKEDRDQFKFLHEPLVRTYSKRVQQRHPHLMEDTQDDEDDSEVDYDETGDSFEEVIHLRNGREVRRSSAAGNAVGGKRRSASAHAITAAANSKRSRSRVMTATIDEEPNEGGTPPKRCRDDGSTPHQEMTTTTTTTTTTTIHNSRAQNQDPPRVSLHRQLTRRSLSCGSIPSCDQTPGQTTNNIGLGMSSAILTKSTLDIRTLKRGTPAWTNGTTRDIAMRPHTFIEAGIKAMRKCDKCATALKLATSMKCRDCHQVVHRSCCNKLHLPCIPRPKTMMTPKSALRGAKPGAGEFRLQDFCTSAKPMIPAAVIHCVVALEARGLTQEGIYRVPGQVRTVNVLLDELRSKTVPNVGLHDVEVITDTLKRFLRDLKDPLIPRTSRQELIVAANLYSTDPDNGRLALNRVICELPQANRDTLAYLFIHWRKVIAQSSRNKMNCEAMARMVAPAVMGHPVKQSQSQAIAGRDATDCHRAMTALFEFDDVYWQRFLGTSAVSMASNQIETARHQDNFALCDRSILGPVTTSPATPLLARSANATRARGAHLLGSMFHD
Protein: Rho GTPase-activating protein 20 (Q9XW53)
Organism: Caenorhabditis elegans
Interaction partners:
- DH domain-containing protein
- Rho-associated protein kinase let-502
- Ras-like GTP-binding protein rhoA
- cGMP-dependent protein kinase interacting domain-containing protein
- Seven TM Receptor
- Formin HOmology Domain
- SH3 domain-containing protein
- Serine/threonine-protein kinase pak-1
Sequence:
MISSNSSSTSLNVETDYPTNGKKPLKEGSVQLTSLSTLLSHHRYFFLYHETLIISKQKGACSYKLKEKLRLEKVWIASSNTADSFLIGWPFTNYLVHFRNTEEKDEWFELLSCCVQQCLRPLFTTISMEINVRGRKQTIRRRVDNGKKSGEIVVDTAGDLGLPHTSYQLTLSFGDNSHRQLQGPENVYVAIMSEIERQGTRLSESQKQALDTCPIANCRLILSTIKSTSGPSAKQLVNSIKKKVLTRTDSRSIFGKGLNGPTPPQPIMTIVDHLRMDGFDAEGIFRKSPKQSTFKELKCELDKGVVPDFHKYNTHVLASILKEYLRSIPGKILLSGNYELWMREIADEPNTEKKVSCCRALLSHLPTSHSILLANVLKLLNKISNSPSSKMNASSLSVCLAPSFLESPDPMEGGKKIPPLIEFLISHAAQVMPGFSTDNVFAIMTSPMVDHNANMVCSPAPSSSHSDDGGSSQKTPIIEELNDADDATSQSSLAESDLPDEPRGTSAHLETISEISEPPTNDERLVFSSSEDEDDDDEDELRVYRPKSSTSTSSCFARTSFVSETLKTSADDGDKGLNKETPRSPCLKRIHFQRTEAQHRNKEGNIKLDFEALKFHRPSVRKSSLEEVARKNSAEFFHHSREPSDAAVTPTPPKNGSTMRKESREEATQTADCGLPHISSNDDSDSRFPAFKSSSVAMLTEPYKSSSSSSSSTSSIPSDPAPRPYFLKEEYTSLANKPTVQVAPFSQEPSLKTINDRLNALRQNSILAQEVPQEPVMTSSRLRSEATKSLTNSPIMPRSYGGSLMQKDREEHSFVADDFYKASSRKPELQRSSSQRGLTSMNNNNNSTKQIYGARPSSLKTPRRFAGAGGVEACVGMDPLEINWSVSQLKTLFQDTKAPSIDTTYNMN
Protein: Transcription factor PDR3 (Pleiotropic drug resistance protein 3) (P33200)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pleiotropic ABC efflux transporter of multiple drugs
- Protein SNQ2
- Transcription factor PDR1
- ATP-dependent permease PDR15
- Oligomycin resistance ATP-dependent permease YOR1
- ATP-dependent permease PDR10
- Zinc finger transcription factor YRR1
- Hexose transporter HXT11
- Ribosome-associated complex subunit SSZ1
- AP-1-like transcription factor YAP1
Sequence:
MKVKKSTRSKVSTACVNCRKRKIKCTGKYPCTNCISYDCTCVFLKKHLPQKEDSSQSLPTTAVAPPSSHANVEASADVQHLDTAIKLDNQYYFKLMNDLIQTPVSPSATHAPDTSNNPTNDNNILFKDDSKYQNQLVTYQNILTNLYALPPCDDTQLLIDKTKSQLNNLINSWNPEINYPKLSSFSPRPQRSIETYLLTNKYRNKIHMTRFSFWTDQMVKSQSPDSFLATTPLVDEVFGLFSPIQAFSLRGIGYLIKKNIENTGSSMLIDTKETIYLILRLFDLCYEHLIQGCISISNPLENYLQKIKQTPTTTASASLPTSPAPLSNDLVISVIHQLPQPFIQSITGFTTTQLIENLHDSFSMFRIVTQMYAQHRKRFAEFLNQAFSLPHQEKSVLFSSFCSSEYLLSTLCYAYYNVTLYHMLDINTLDYLEILVSLLEIQNEIDERFGFEKMLEVAVTCSTKMGLSRWEYYVGIDENTAERRRKIWWKIYSLEKRFLTDLGDLSLINEHQMNCLLPKDFRDMGFINHKEFLTKIGTSSLSPSSPKLKNLSLSRLIEYGELAIAQIVGDFFSETLYNEKFTSLEVSVKPTIIRQKLLEKVFEDIESFRLKLAKIKLHTSRVFQVAHCKYPEYPKNDLIEAAKFVSYHKNTWFSILGAVNNLIARLSEDPEVITEQSMKYANEMFQEWREINQFLIQVDTDFIVWACLDFYELIFFVMASKFYVEDPHITLEDVINTLKVFKRITNIISFFNNNLDEKDYDCQTFREFSRSSSLVAISIRIIFLKYCYAEQIDRAEFIERLKEVEPGLSDLLREFFDTRSFIYRYMLKSVEKSGFHLIIRKMLESDYKFLYRDKLATGNIPDQGNSSQISQLYDSTAPSYNNASASAANSPLKLSSLLNSGEESYTQDASENVPCNLRHQDRSLQQTKRQHSAPSQISANENNIYNLGTLEEFVSSGDLTDLYHTLWNDNTSYPFL
Protein: Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit) (P08543)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Ribonucleoside-diphosphate reductase holoenzyme that provides the precursors necessary for viral DNA synthesis (By similarity). Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Prevents host necroptosis by targeting host RIPK1 and RIPK3, thereby hampering the formation of necroptotic RIPK1-RIPK3 complexes. Forms hetero-amyloid structures with host proteins RIPK3 or ZBP1 which may prevent RIPK3- and ZBP1-mediated necroptosis. In addition, inhibits extrinsic apoptosis by targeting host CASP8.
Interaction partners:
Sequence:
MASRPAASSPVEARAPVGGQEAGGPSAATQGEAAGAPLAHGHHVYCQRVNGVMVLSDKTPGSASYRISDNNFVQCGSNCTMIIDGDVVRGRPQDPGAAASPAPFVAVTNIGAGSDGGTAVVAFGGTPRRSAGTSTGTQTADVPTEALGGPPPPPRFTLGGGCCSCRDTRRRSAVFGGEGDPVGPAEFVSDDRSSDSDSDDSEDTDSETLSHASSDVSGGATYDDALDSDSSSDDSLQIDGPVCRPWSNDTAPLDVCPGTPGPGADAGGPSAVDPHAPTPEAGAGLAADPAVARDDAEGLSDPRPRLGTGTAYPVPLELTPENAEAVARFLGDAVNREPALMLEYFCRCAREETKRVPPRTFGSPPRLTEDDFGLLNYALVEMQRLCLDVPPVPPNAYMPYYLREYVTRLVNGFKPLVSRSARLYRILGVLVHLRIRTREASFEEWLRSKEVALDFGLTERLREHEAQLVILAQALDHYDCLIHSTPHTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGREGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNKATLRAITSNVSAILARNGGIGLCVQAFNDSGPGTASVMPALKVLDSLVAAHNKESARPTGACVYLEPWHTDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWTLFDRDTSMSLADFHGEEFEKLYQHLEVMGFGEQIPIQELAYGIVRSAATTGSPFVMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDLESAEFQDLNKHIAEVMLLSAMKTSNALCVRGARPFNHFKRSMYRAGRFHWERFPDARPRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFSGKRLLEVMDSLDAKQWSVAQALPCLEPTHPLRRFKTAFDYDQKLLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFGGDDNIVCMSCAL
Protein: AP-3 complex subunit mu (Q20736)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- AP-3 complex subunit beta
- AP-3 complex subunit delta
- AP complex mu/sigma subunit domain-containing protein
- AP-1 complex subunit gamma
- AP-2 complex subunit alpha
- Homolog of Hedgehog AcylTransferase
- ACid Phosphatase family
- Ras-related protein Rab
- X-linked retinitis pigmentosa GTPase regulator homolog
- Uncharacterized protein.
Sequence:
MLNSLFFVNSSGDVLLEKHWKSVIHRSICDYFFDIQKKSIHPEDVPPIISTPHHYLINVYQNNLFLVAVITVETPPLMVIEFLHRVIQTFTQYFDEFSDSSMKENCVMVFELLDEMLDNGFPLVTEMNILQDLIKPPNFLRNIANQVTGRTNLSETLPTGQLSNIPWRRQGVKYTNNEAYFDVIEEIDVIVDKQGSTVFAEIQGYVDVCCKLSGMPDLTMTLINPRLLDDVSFHPCVRYKRWENEKVLSFVPPDGNFRLLSYHIAAQNMVAIPIYVRQVISLKPNAGKLDLTVGPKLSMGKVLEDVVLEITMPKCVQNCNLVASHGRIAFDPTTKLLQWTIGKIEVGKPSTLKGSVAVSGTTVAENPPISLKFKINQLVLSGLKVNRLDMYGEKYKPFKGVKYITKAGKFTIRT
Protein: diguanylate cyclase (EC 2.7.7.65) (A0A0H2X5F3)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Interaction partners:
Sequence:
MPETWMRLYAGLSRLFPRSFSAKLLAVTFVGIHLPLLLLIAWLAAQSELDGRPLWSVVIVALLATLAGTALTLSALYRLLAPLRIAADALDAYYADQRLPTLPEHGDDELGRLLRGINRSLRGIDAGMRDLKRHALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEREDAEEAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRDGHDAPRSHPVA
Protein: Small ribosomal subunit protein uS9A (40S ribosomal protein S16-A) (RP61R) (P0CX51)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS26A
- Small ribosomal subunit protein uS2A
- Small ribosomal subunit protein eS10B
- rRNA 2'-O-methyltransferase fibrillarin
- Serine/threonine-protein kinase RIO2
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS14B
Sequence:
MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR
Protein: Transcription factor E2F1 (E2F-1) (Q61501)
Organism: Mus musculus (Mouse)
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (By similarity). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (By similarity). It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10 (By similarity). Positively regulates transcription of RRP1B (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q01094}.
Interaction partners:
- Transcription factor Dp-1
- Cyclin-A2
- Retinoblastoma-associated protein
- Cyclin-A1
- Transcription factor Dp-2
- Histone deacetylase 1
- Forkhead box protein O3
- Cyclin-dependent kinase 2
- Myc proto-oncogene protein
- Retinoblastoma-like protein 2
Sequence:
MAVAPAGGQHAPALEALLGAGALRLLDSSQIVIISTAPDVGAPQLPAAPPTGPRDSDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSRSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTMVGIGKRLEGLTQDLQQLQESEQQLDHLMHICTTQLQLLSEDSDTQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAVDSSETFQISLKSKQGPIDVFLCPEESADGISPGKTSCQETSSGEDRTADSGPAGPPPSPPSTSPALDPSQSLLGLEQEAVLPRMGHLRVPMEEDQLSPLVAADSLLEHVKEDFSGLLPGEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF
Protein: Splicing factor YJU2 (A8WHR3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BW85, ECO:0000255|HAMAP-Rule:MF_03226}.
Interaction partners:
- Pleiotropic regulator 1.
- Cell division cycle 5-like protein
- CWC25 spliceosome-associated protein homolog
- DEAH
- Pre-mRNA-splicing factor SYF1
- Protein BUD31 homolog
- Pre-mRNA-splicing factor CWC22 homolog
- Pre-mRNA-processing factor 19
- Activating signal cointegrator 1 complex subunit 3
- Crooked neck-like protein 1
Sequence:
MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNELYLGLPIFRFYIKCTRCLAEITFKTDPENTDYAMEHGATRNFQAEKLIEEEEKKIQQEREDEELNNPMKVLENRTRDSKLEMEVLENLQELKELNQRQAQVDFEGMLGQYKELEQRQKQREQEEDEQETKEMLERALVKRLRDSDSEEEAENAKERSKKHIADKPTDILTTDTSTSSQGLSSAVAKKQSWDRSVGGLSVKGALGSLVVRKKPADSASKPSHAAPPPAAAAAGTQTGAVKPESSITSSSASSNIQPVSCQNGSSLGLLGAYSDSDDSSSD
Protein: Insulin-like growth factor 2 (Insulin-like growth factor II) (B8QGI3)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MGITAGKSVLVLLAFLAFASCCYAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPSSRINRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSASTTVLPDDVTAYPVGKFFQYDIWKQSTQRLRRGLPAFLRARRGRTLAKELEALREAKSHRPLIALPTQDPATHGGASSKASSD
Protein: HCG40295, isoform CRA_d (Tetratricopeptide repeat domain 39A) (F6WE04)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTALDLFLTNQFSEALSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLLQRAALTFLQDENMVSFIKGGIKVRNSYQTYKELDSLVQSSQYCKGENHPHFEGGVKLGVGAFNLTLSMLPTRILRLLEFVGFSGNKDYGLLQLEEGASGHSFRSVLCVMLLLCYHTFLTFVLGTGNVNIEEAEKLLKPYLNRYPKGAIFLFFAGRIEVIKGNIDAAIRRFEECCEAQQHWKQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATYIYMKAAYLSMFGKEDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGLCLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENSSRSMVSSVSL
Protein: signal peptidase I (EC 3.4.21.89) (Q9LW08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Cyanate hydratase
- Signal peptidase complex subunit 1
- Signal peptidase complex subunit 1
- Signal peptidase complex subunit 3B
- Signal peptidase complex subunit 3A
- Probable galacturonosyltransferase 7
- Signal peptidase complex catalytic subunit SEC11
- Probable glutamyl endopeptidase, chloroplastic
- Probable thylakoidal processing peptidase 2, chloroplastic
- Thylakoidal processing peptidase 1, chloroplastic
Sequence:
MGFIGETVDSIKSIKIRQVLTQAITLGMIVTSALIIWKALICVTGSESPVVVVLSESMEPGFQRGDILFLRMTDEPIRAGEIVVFSVDGREIPIVHRAIKVHERGDTKAVDVLTKGDNNDIDDIGLYAEGQLWLHRHHIMGRAVGFLPYVGWVTIIMTEKPIIKYILIGALGLLVITSKD