Protein: SCO-spondin (Q8CG65)
Organism: Mus musculus (Mouse)
Function: Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity).
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:P98167}.
Interaction partners:
- Platelet glycoprotein Ib alpha chain
- Ubiquitin-like protein FUBI
- Coagulation factor VIII
Sequence:
MLPLALLFGMLWTQANGHWCEQIETVHVEEEVTPRQEDLVPCTSLYHYSRLGWQLDLSWSGRVGLTRPPALGLCAIYKPPETRPATWNRTVRACCPGWGGAHCTDALAETSPKGHCFVTWHCQPLAGSANSSAGSLEDPADELGVWPLTLNDPILFPGMSLQWQGDWLVLSGGLGVVVRLDRSSSISISVDHEFWGRTQGLCGLYNGRPEDDFVEPGGGLATLAATFGNSWKLPGSEPGCLDAVEVAWGCESLLGGTLTDLEAVKLQAQAQDMCHQLLEGPFWQCHGQVQPDEYHETCLFAYCVGATAGNGPEGQLEAVCATFANYAQACARQHIYVHWRKPGFCERVCPGGQLYSDCVSSCPPSCSAVAQGEEGSCGKECVSGCECPTGLFWDGALCVPAAHCPCYHRRQRYAPGDTVKQQCNPCVCQDGRWHCAQALCPAECAVGGDGHYFTFDGRSFFFRGTPGCHYSLVQDSVKGQLLVVLEHGACDTGSCLHALSVFLGNTHIQLRYSGAVLVDGEDVDLPWIGVEGFNISWASSTFLLLHWPGAWVLWGVAEPAAYITLDPRHAYQVQGLCGTFTWKQQDDFLTPAGDIETSVTAFASKFQVSGDGRCPLVDKSPLFCSSYSQHLTFTEAACAILHGHAFQECHGLVDREPFRLRCLEAVCGCAPGRDCLCPVLSAYTRHCAQEGVLLQWRNETLCPVSCPGGQVYQECAPVCGHHCGEPEDCKELGICVAGCNCPPGLLWDLEGQCVPPSMCHCQFGGHRYTINTTTVRDCSHCICQERGLWNCTAHHCPRQWALCPRELIYVPGACLLTCDSPRANHSCWAGSTDGCVCPPGTVLLDKHCVSPDLCPCRHNGQWYPPNATIQEDCNICVCQGQRWHCTGQRCSGWCQASGAPHYVTFDGLVFTFPGACEYLLVREAGGRFSVSVQNLPCGASGLTCTKALVVRLDSTVVHMLRGQAVTVNGVSIRLPKVYTGPGLSLHHAGLFLLLTTRLGLTLLWDGGTRVLVQLSPHFHGRVAGLCGNFDSDASNDLRSRQGVLEPTAELTAHSWRLNPLCPEPGDLPHPVNAHRANWARARCEVILQPIFAPCHTEVPPQQYYEWCVYDACGCDTGGDCECLCSAIATYADECARHRHHVRWRSQELCPLQCEGGQVYEPCGSTCPPTCHDHHSELRWHCQVITCVEGCFCPEGTLLHGGACMKLAACPCEWQGSFFPPGTVLQKDCGNCTCQGSQWHCDRGGAPCEDMEPGCAEGETLCRENGHCVPLEWLCDNQDDCGDGSDEEGCATSVCGEGQMSCQSGHCLPLSLICDGQDDCGDGTDEQGCLCPHGSLACADGRCLPPALLCNGHPDCLDAADEESCLGPVSCISGEVSCVDGTCVRTIQLCDGVWDCPDGADEGPSHCSLPSLPTPPGGIGQNPSTSSLDTAPSPVGSTSPASPCSLLEFQCNSGECTPRGWRCDQEEDCTDGSDELDCGGPCMLYQVPCAHSPHCVSPGQLCDGVTQCPDGSDEDPDVCEEQSASGGANRTGAPCPEFSCPDGTCIDFLLVCDGNPDCELADETEPSLDEQGCGAWGSWGPWAPCSQTCGSGTRSRNRNCSTSSLQVLQNCPGLQHQSQACFTEACPVDGEWSSWSPWSPCSEPCGGTTTRHRQCRPPQNGGQDCALLPGSTHSTRQTSPCPQEGCLNATCFGELVFRTCAPCPLTCDDISGQAACPPDRPCSSPGCWCPDGKVLNTEGQCVRPRQCPCLVDGAHYWPGQRIKMDCQLCFLDCGWSSWSPWAECLGPCSSQSLQWSFRSPNNPRLSGHGRQCRGIHRKARRCQTEACEGCEQWGLMYNVGERWRGGPCMVCECLHSSITHCSPYCPIGSCPQGWVLVEGMGESCCHCALPEKNQTVIHMTTPAPAPASAPSPQIGAHLVTYVLPPTADACYSPLGLAGLPMWAPSQHWEHITRADPVEAPMAGPGPREGASAEWHTQPLYLQLDLRRPRNLTGIIVQRAGSSAAYVSTLSLQFSSDNLQWHNYVNSLSSTLSPPKPSPESSNHMAPEVWTFDQMVQARYIRVWPHSGHLRDNNQHDIFLWVELLGLSPLAPLCPGSRHRCASGECAPKGGPCDGAVDCDDGSDEEGCGSLHASTTSRTPALSPTQPGKFPREVSEDLRQGAEAMTSHSPPSSGETAGLIPASEGTLPVSGQPMQTLSATSTFPPGAKSLHPGMAAVTVHPPHSVTPGAPVGQTVSPRPFPPMPCGPGQVPCDVLGCVEQEQLCDGREDCLDGSDEQHCASAEPFTVPTTALPGLPASKALCSPSQLRCGSGECLPFEHRCDLQVNCQDGSDEDNCVDCVLAPWSGWSDCSRSCGLGLIFQHRELLRLPLPGGSCLLDQFRSQSCFVQACPVAGAWAEWGPWTACSVSCGGGHQSRQRSCVDPPPKNGGAPCPGPSHEKAPCNLQLCPGDTDCEPGLVHVNAELCQKGLVPPCPPSCLDPEANRSCSGHCMEGCRCPPGLLLQDSHCLPLSECPCLVGQKLIQPRLAFLLDNCSQCICEKGTLLCKPGACSQSCGWSAWSPWTACDRSCGSGVRARFRSPTNPPVAFGGSPCEGDRQELQACYTDCGTEIPGWTPWTSWSSCSQSCLVPGGDPGWRQRSRLCPSSRDTFCPGEATQEEPCSPPVCPVPSAWGLWASWSTCSASCNGGIQTRGRSCSGSAPGNPVCLGPHTQTRDCNMHPCTAQCPGNMVFRSAEQCLEEGGPCPQLCLAQDPGVECTGSCAPSCNCPPGLFLHNASCLPRSQCPCQLHGQLYAPGAVAHLDCNNCTCISGEMVCTSKRCPVACGWSPWTPWSPCSQSCNVGIRRRFRAGTEPPAAFGGAECQGPNLDAEFCSLRPCRGPGAAWSSWTPCSVPCGGGYRNRTQGSGPHSPIEFSTCSLQPCAGPVPGVCPEDQQWLDCAQGPASCAHLSIPGEANQTCHPGCYCLSGMLLLNNVCVPVQDCPCAHRGRLYSPGSAVHLPCENCSCISGLITNCSSWPCEEGQPAWSSWTPWSVCSASCNPARRHRHRFCARPPHRAPFSLVLLTTVAAPTTLCPGPEAEEEPCLLPGCNQAGGWSPWSPWSGCSRSCGGGLRSRTRACDQPSPQGLGDFCEGPQAQGEACQAQPCPVTNCSAMEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPLGKVLSADGAICVKPSYCSCLDLLTGKRHHAGTQLMRPDGCNHCTCMEGRLNCTDLPCQVSGDWCPWSKWTACSQPCRGQTRTRSRACVCPAPQHGGSPCPEESGGTGVQHQMEACPNATACPVDGAWSPWGPWSSCDACLGQSYRSRVCSHPPISDGGKPCLGGYQQSRPCRNSSTLCTDCGGGQDLLPCGQPCPHSCQDLSLGSTCQPGSAGCQSGCGCPPGQLSQDGLCVFPVDCHCHFQPRAMGIPENRSRSVGSTLSSWESLEPGEVVTGPCDNCTCVAGILQCHEVPSCPGPGIWSSWGPWEKCSVSCGGGEQLRSRQCARPPCPGLAQQSRICHIHVCRETGCPAGRLYRECQPSDGCPFSCAHVTGQVACFSERCKEGCHCPEGTFQHHVACVQECPCVLTVLLLQELGLASAALGSYPTLLGDEGKPLGPGVELLPGQMLQTDCGNCSCVHGKLSCSMVECSRVHGSFGPWGMWSLCSRSCGGLGTRTRTRQCVLPTLAPGGLSCRGPLQDLEYCFSPECPGTAGSTVEPVTGLAGGWGPWSPWSPCSHSCTDPAHPAWRSRTRLCLANCTVGDSSQERPCNLPSCAALLPCPGPGCGSGNCFWTSWAPWEPCSRSCGVGQQRRLRAYHPPGPGGHWCPDILTAYQERRFCNLRACPVPGGWSHWSPWSWCDRSCGGGRSLRSRSCSSPPPKNGGTSCVGERHHVRPCNPMPCEEGCPAGMEMVSCANHCPYSCSDLQEGGMCQEDQACQLGCRCSEGFLEQDGGCVPVGHCECTDAQGRSWAPGSQHQDACNNCSCQAGQLSCTAQLCSPPAHCAWSHWSAWSSCSHSCGPQGQQSRFRSSTSGSWALECQKEQSQSQPCPEVPCPPLCLHEAHLHELGDNWLHGECQQCSCTPEGAICKDTDCAVPRGWTLWSSWSYCSVSCGGGSQVRTRSCTVSAPPHGSLSCEGPDTQTRHCGQQLCLQKLERCSWGPWGPCSRSCGTGLASRSGSCPCLLTKEDSKCNDTFLGLDTQACYSGPCQDDCTWGDWSSWTRCSCKVLVQQRYRHQVPAPGQAGEGTPCTRLDGHFRPCTIGNCSEDSCPPPFEFQSCGSPCAGLCATHLNHRLCQDLPPCQPGCYCPKGLLEQAGSCILPEQCNCWHISGEGARVTLAPGDRLQLGCKECVCRRGELQCSSQGCEGLLPLTGWSEWSPCGPCLPQSALAPASRTALEGHWPLNTSDLPPPSVTLLASEQYRHRLCLDPETRRPWAGDPALCTVPLSQQRLCPDPGACNDTCQWGPWGPWSPCQMPCSGGFKLRWRVARDTSAGECPGPWAQTESCNMGSCPGESCETRDTVFTLDCANQCPRSCADLWDGVQCLQGPCSPGCRCPPGQLVQDGHCVPISSCRCGLPSANASWELAPTQVVQLDCHNCTCINGTLMCPHLECPVLGPWSAWSECSAVCGKGTMVRHRSCEEHPDREPCQALDLQQWQECNLQACPECPPGQVLSTCATMCPSLCSHLWPGTICVREPCQLGCGCPGGQLLYNGTCIPPEACPCTQFSLPWGLTLPLEEQARELPSGTVLTRNCTHCTCQGGAFICSLTDCQECAPGEIWQHGKLGPCEKTCPEMNMTQAWSNCTEAQAPGCVCQLGYFRSQTGLCVPEDHCECWHHGSPHLPGSEWQEACESCRCLHGKSVCIRHCPELSCAQGEVIMQEPGSCCPICQQDTLKEEPVSCRYLTELRNLTKGPCHLDQIEVSYCSGHCRSSTNVMTEEPYLQSQCDCCSYRLDPDSPVRILNLLCPDGHTEPVVLPVIHSCQCSACQGGDFSKH