wanglab/gogpt-training-data huggingface dataset:
Protein: Testis-specific gene 10 protein (Testis development protein NYD-SP7) (Q9BZW7)
Organism: Homo sapiens (Human)
Function: Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Z220}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28905369}. Note=In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity). {ECO:0000250|UniProtKB:Q9Z220, ECO:0000269|PubMed:28905369}.
Interaction partners:
- Polyamine-modulated factor 1-binding protein 1
Sequence:
MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF
Protein: CWF19-like protein DRN1 (Debranching enzyme-associated ribonuclease 1) (P53255)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in branched RNA metabolism, modulating the turnover of lariat-intron pre-mRNAs by the lariat-debranching enzyme DBR1. Enhances the debranching activity of DBR1 in vitro.
Subcellular location: Nucleus. Cytoplasm. Note=Relocalizes to the cytoplasm in response to hypoxia.
Interaction partners:
- Pre-mRNA-splicing factor CEF1
- Lariat debranching enzyme
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor SPP382
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Pre-mRNA-splicing factor NTR2
- Pre-mRNA-splicing factor ISY1
- Pre-mRNA-splicing factor SYF2
Sequence:
MTNAKILVAHISESDADEAIRKIKKVNEKSGPFDLIIIFSNSYDENFELNTDGLPQLILLSCDKANNSKSKKINENVTLLHNMGTYKLANGITLSYFIYPDDTLQGEKKSILDEFGKSEDQVDILLTKEWGLSISERCGRLSGSEVVDELAKKLQARYHFAFSDEINFYELEPFQWERERLSRFLNIPKYGSGKKWAYAFNMPIGDNELKDEPEPPNLIANPYNSVVTNSNKRPLETETENSFDGDKQVLANREKNENKKIRTILPSSCHFCFSNPNLEDHMIISIGKLVYLTTAKGPLSVPKGDMDISGHCLIIPIEHIPKLDPSKNAELTQSILAYEASLVKMNYIKFDMCTIVFEIQSERSIHFHKQVIPVPKYLVLKFCSALDRQVHFNNEKFTRNAKLEFQCYDSHSSKQYVDVINNQSNNYLQFTVYETPEADPKIYLATFNASETIDLQFGRRVLAFLLNLPRRVKWNSSTCLQTKQQETIEAEKFQKAYRTYDISLTEN
Protein: Transmembrane protein, putative (DUF707) (Q8VYF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2-like protein
- H/ACA ribonucleoprotein complex subunit 3-like protein
- H/ACA ribonucleoprotein complex subunit 1-like protein 2
- Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1
- Nucleolar protein 56
- Nucleolar protein 56
- Probable ribosome-binding factor A
- At4g22380
- At4g01790
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein
Sequence:
MANRTDNSNRCSNGKKPNDGMRLIIATFVGIVVGFFLGISFPTLSLTKLNFPSGILPSVDITYVEDETPETSSETLLHTWSSRGPLHGANSSDAPHWKIWVPSNPRGAEMLTPGIIAPESDYYLRRLWGLPEEDVPVKPKYLIAFTVGFGQKVNVDACVKKFSKDFTIVLFHYDGRTTEWEELEWSKRAIHVSVPKQTKWWYAKRFLHPDIVAPYDYVFIWDEDLGLENFDVEEYIRLIKKHGLEISQPAVESKKKITWEITKRKTKGEVHKDAKEKPGRCNDPHLPPCAAFIEIMAPVFSRDAWRCVWHMIQNDLVHGWGLDFALRKCVEPAHEKIGVVDSQWIIHQSLPSLGSQGEAQDGKAGWQGVRDRCKREWTMFQSRMASSEKQYLKEIANSTIH
Protein: TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) (Q9BSI4)
Organism: Homo sapiens (Human)
Function: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Subcellular location: Nucleus {ECO:0000269|PubMed:19279399}. Chromosome, telomere {ECO:0000269|PubMed:19279399}. Note=Associated with telomeres.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus matrix {ECO:0000269|PubMed:19229133}.
Interaction partners:
- Telomeric repeat-binding factor 2
- Telomeric repeat-binding factor 1
- Protection of telomeres protein 1
- Adrenocortical dysplasia protein homolog
- Telomeric repeat-binding factor 2-interacting protein 1
- Tripeptidyl-peptidase 1
- Poly [ADP-ribose] polymerase tankyrase-1
- CST complex subunit CTC1
- H/ACA ribonucleoprotein complex subunit DKC1
- Telomerase reverse transcriptase
Sequence:
MATPLVAGPAALRFAAAASWQVVRGRCVEHFPRVLEFLRSLRAVAPGLVRYRHHERLCMGLKAKVVVELILQGRPWAQVLKALNHHFPESGPIVRDPKATKQDLRKILEAQETFYQQVKQLSEAPVDLASKLQELEQEYGEPFLAAMEKLLFEYLCQLEKALPTPQAQQLQDVLSWMQPGVSITSSLAWRQYGVDMGWLLPECSVTDSVNLAEPMEQNPPQQQRLALHNPLPKAKPGTHLPQGPSSRTHPEPLAGRHFNLAPLGRRRVQSQWASTRGGHKERPTVMLFPFRNLGSPTQVISKPESKEEHAIYTADLAMGTRAASTGKSKSPCQTLGGRALKENPVDLPATEQKENCLDCYMDPLRLSLLPPRARKPVCPPSLCSSVITIGDLVLDSDEEENGQGEGKESLENYQKTKFDTLIPTLCEYLPPSGHGAIPVSSCDCRDSSRPL
Protein: Ribosome biogenesis protein erb1 (Eukaryotic ribosome biogenesis protein 1) (O74399)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:16823372}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
Interaction partners:
- ATP-dependent RNA helicase has1
- Ribosome biogenesis protein brx1
- Ribosome biogenesis protein nsa1
- Ribosome biogenesis protein ytm1
- Eukaryotic translation initiation factor 6
- Ribosome biogenesis protein rlp24
- GTPase grn1
- Ribosome assembly factor mrt4
- Pescadillo homolog
- Probable nucleolar GTP-binding protein 1
Sequence:
METGMNRKRSRSKRANSNVGVEKDKEKEKSKGVSNVPNEVETESSSHEPSFKKDVDEEIPSLTAELSEEEEGEYSSESGRSTPELSPDDFEDADDEEEFEEIDAGYSSDSSTEDVAPGLYESPYDENLYINYDIDGKKITRPATPAALDSLIASIDKDKGWTGIVDPMTGKPVNLTTEELGLLKRLAQSEIPDENFDPYPDYDDFFTNTVRETPLSSAPEPKRRFAPSKHEQKRILQLAYAIRKGRILTSEQRAERERESQSNYADHDLWADDDQATVNQRKLDYAPAPKLPPPSHEESYNPPEEYLKQSSDFPKKYKSLRVVPAYSNLIKEKFERCLDLYLAPRVRRTKLNIDPESLLPKLPTPSELRPFPTRCTNVFIGHKGRVRCLSVHVSGNWLASGGDDGVLRIWEVMTGRCVWKCSLDSFGNAHNIDSDEDAVNESLSHSTKSSIIQSLAWGPLSDSPVLAVAVDETVYFITPPIFSDEQIEASKELFTSAPYQESSAIWRRGAKQSLQLHGGIVHATVSTPSSIKSLSWHRRGDYLATSSPTSSSQAVLIHQLSRGASQSPFSKSKGSVQAVTFHPTMPYLLVATQRYVRIYNLVKQELVKTLLTGVKWVSSLSVHSSGDHVIIGSYDKRLCWFDLDFSSKPYKNLRYHSRALRDVSYHPSLPLFCSGSDDGDVQVFHGRVYSDLLANPLIVPLKILRNHKVVDNVGVLSTCWHPKEAWLFSAGAGGEIRMWT
Protein: Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Q5ZME2)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P40925}.
Interaction partners:
- Citrate synthase, mitochondrial
- Fumarate hydratase, mitochondrial
- Malate dehydrogenase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Malic enzyme
- Malic enzyme.
- ATP-citrate synthase
- Lipoyl-binding domain-containing protein.
- Phosphoenolpyruvate carboxykinase, mitochondrial
Sequence:
MGEPIRVLVTGAAGQIAYSLLYSIAKGDVFGKEQPLVLVLLDITPMMTVLEGVVMELQDCALPLLREVIPTDKEEVAFKDLDIAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKTVKVVVVGNPANTNCLIASKSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTSNDVKNVIIWGNHSSTQYPDVNHAKVNVKGKEVGVYEAIKDDSWLKGDFILTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPAGEFVSMGVISDGNSYGVPEDLLYSFPVVIKDKTWKFVEGLPINDFSREKMDLTAKELTEEKETAVEFLSSA
Protein: Transcription elongation factor (Q6IB64)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00649, ECO:0000256|RuleBase:RU368078}.
Interaction partners:
Sequence:
MMGKEEEIARIARRLDKMVTKKSAEGAMDLLRELKAMPITLHLLQSTRVGMSVNALRKQSSDEEVIALAKSLIKSWKKLLDASDAKARERGRGMPLPTSSRDASEAPDPSRKRPELPRAPSTPRITTFPPVPVTCDAVRNKCREMLTAALQTDHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCNECGNRWKFC
Protein: Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (Myosin heavy chain, skeletal muscle, adult 2) (I6L963)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, myofibril {ECO:0000256|ARBA:ARBA00004657}.
Interaction partners:
Sequence:
MSSDAEMAVFGEAAPYLRKSEKERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATLTVKEDQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDDLAKSEAKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTSQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKPAMQKRKPRKPSLMPP
Protein: Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct) (P56402)
Organism: Mus musculus (Mouse)
Function: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:16641094, ECO:0000269|PubMed:16735444}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Basolateral cell membrane {ECO:0000250|UniProtKB:P34080}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Cell membrane {ECO:0000269|PubMed:10191086}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10191086}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P41181}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:16735444). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. {ECO:0000250|UniProtKB:P41181, ECO:0000269|PubMed:16735444}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Vasopressin V2 receptor
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Aquaporin-12
- Aquaporin-11
- Uromodulin
- Urea transporter 2
- Epithelial sodium channel subunit alpha
- Epithelial sodium channel subunit gamma
Sequence:
MWELRSIAFSRAVLAEFLATLLFVFFGLGSALQWASSPPSVLQIAVAFGLGIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAAILHEITPVEIRGDLAVNALHNNATAGQAVTVELFLTMQLVLCIFASTDERRSDNLGSPALSIGFSVTLGHLLGIYFTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAVIGSLLYNYLLFPSTKSLQERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGSKA
Protein: Superoxide dismutase [Mn] 3.4, mitochondrial (EC 1.15.1.1) (P41980)
Organism: Zea mays (Maize)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Superoxide dismutase 4A
- superoxide dismutase
- Superoxide dismutase
- Superoxide dismutase 2
- Superoxide dismutase 4AP
- Superoxide dismutase
- superoxide dismutase
- Superoxide dismutase
- Large ribosomal subunit protein uL23m
- Ribosomal protein S5 family protein
Sequence:
MALRTLASKNALSFALGGAARPSAASARGVTTVALPDLSYDFGALEPAISGEIMRLHHQKHHATYVGNYNKALEQLDAAVAKGDASAVVQLQGAIKFNGGGHVNHSIFWKNLKPISEGGGEPPHGKLGWAIDEDFGSFEALVKRMNAEGAALQGSGWVWLALDKEPKKLSVETTANQDPLVTKGASLVPLLGIDVWEHAYYLQYKNVRPDYLNNIWKVMNWKYAGEVYENVLA
Protein: HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) (Q9UGU5)
Organism: Homo sapiens (Human)
Function: Negatively regulates Wnt/beta-catenin signaling during development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- BPTF-associated chromatin complex component 1
- Nucleosome-remodeling factor subunit BPTF
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Histone-binding protein RBBP4
- Target of Myb1 membrane trafficking protein
- Chromatin remodeling regulator CECR2
- Bromodomain adjacent to zinc finger domain protein 1A
- DNA replication licensing factor MCM5
- Tyrosine-protein kinase BAZ1B
Sequence:
MAYDDSVKKEDCFDGDHTFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHKKKRKHSSDDYYYGDISSLESSQKKKKKSSPQSTDTAMDLLKAITSPLAAGSKPSKKTGEKSSGSSSHSESKKEHHRKKVSGSSGELPLEDGGSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQATVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDAHSSPGPEGCGSDASQFAESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSLGLSAVPVGEVTVTSGPPPSIPYAGAAAPPLPLPGLHTDGHSEKKKKKEEKDKERERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSVGVLSPQKKSPPTTMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL
Protein: Choline transporter BetT (Q9HTI9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- HTH-type transcriptional regulator BetI
- Oxygen-dependent choline dehydrogenase
- NAD/NADP-dependent betaine aldehyde dehydrogenase
Sequence:
MFFGSTALILVLTAALILYPDSAGALLGRIQEWLSHSFGWYYMLAIGAYLFFVAWVAFSRFGTLKLGEEHEKPDFSYGAWAGMLFSSGIGISLLYFAASEPIDHLYHPPEGVPGSPQAARQALQLTFLHWGLHGWAIYALVGLAVGYFAYRHRQPLALRSALYPILGERWVKGAAGHAVDCFGIFVTLLGLVTNLGIGALQVSSGLEYLTGMPHSKGTLLAVILAMSLVATLAAVSGVEKGIRRLSNLNIVLFSSLLLFVLVCGSTLELLNGFVQNLGDYLDGLVLKTFDLYVYTGAGAGKSEEWLGLWTLFYWAWWISWAPFVGMFIARISRGRSVRELVCGVLLIPLGFTLAWLSVFGNSALDLVMNHGATDLGKAALEQPSMSIYLLLEHYPLSKIVIGLSIFVGFVLFLTPADSGSVMLANLSRSGGELDEDAPNWLRILWSAVVTLVTIGLLFAGNFTAMQTVVVLAGLPFSAVLILFMFGLHKAMRADYEAQVGDRRTYQPVPAPTQPQT
Protein: (-)-kolavenyl diphosphate synthase, chloroplastic (SdKPS) (EC 5.5.1.28) (Clerodienyl diphosphate synthase) (Kolavenyl diphosphate synthase CPS2) (SdCPS2) (A0A1S5RW73)
Organism: Salvia divinorum (Maria pastora) (Diviner's sage)
Function: Involved in the biosynthesis of clerodane diterpenoids natural products, including salvinorin A with potent agonistic activity on brain kappa-opioid receptors, thus confering hallucinogenic properties. Diterpene synthase that catalyzes the formation of (-)-kolavenyl diphosphate from geranylgeranyl diphosphate (GGPP) as the first reaction in salvinorin A biosynthesis.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSFATSLPRPTTTGAAGFGLPLATCISLSVSHSFSPKFGICNNTSLRLKSKAGSGCYEGIHRSQLAASTILEGHTPINPEVESEKIRLIERIRLMFRSMDDGEISVSPYDTAWVALVEDIGGSGGPQFPTSLEWISNNQLDDGSWGDRKFVLYDRILNTLACVVALTTWKMHPNKCEKGLRFISDNIEKLADEDEELMPVGFEIALPSLIDLAKRLCIEIPDNSASIKNIYAKRDSKLKRIPMDLMHKKPTSLLFSLEGMEGLNWDKLLDFQSEGSFLSSPSSTAYALHHTKDELCLEYLLKAVKKFNGGVPNAYPVDMFEHLWSVDRLRRLGISRYFQVEIDECLDYVYRYWTNKGICWARNMCVQDSDDSSMGFRLLRLYGYDVSIDVFKQFEEGGQFCSIPGQMTHAITGMYNLYRASQLMFPQEHILADARNFTANLLHQKRVTNSIVDKWIITKDLPGEVAYALDVPFYASLPRLEARFFLEQYGGDDDVWIGKTLYRMLYVNCNTYLELAKLDYKHCQTVHQLEWNSMQTWYRECNLGEFGLSERSLLLAYYIAASTAFEPEKSSERLAWAITTILVETIMSQELSDEQKREFVDEFVNISIINNQNGGRYKPGNRLVEVLINTVTLMAEGRGTDQQLSNAWKNWLKTWEEGGDLGEAEARLLLHTIHLSSGLDESSFSHPKYQQLLEATSKVCHQLRLFQNLKANDAQGSTSRLVTVTTFQIEAGMQELVKLIFTKTLEDLTSATKQSFFNIARSFYYTAYCPADTIDSHINKVLFEKIV
Protein: Probable calcium-binding protein CML21 (Calmodulin-like protein 21) (Q52K82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML34
- Probable calcium-binding protein CML25
- Probable calcium-binding protein CML49
- Probable calcium-binding protein CML14
- Probable calcium-binding protein CML13
- Probable calcium-binding protein CML35
- Probable calcium-binding protein CML36
- Probable calcium-binding protein CML16
- Probable calcium-binding protein CML29
- Probable serine/threonine-protein kinase PBL16
Sequence:
MGGAVTKSETLQKEWVPETKLEAKIIEAVQRRASRGTTMKSFNSIVLKFPKIDDGLRNCKAIFQEFDEDSNGSIDHTELKNCIRKLEISFDEEEINDLFKACDINEDMGITFTEFIVLLCLVYLLKDDSSTLQKKWTMGMPKLEPTFETLVDTFVFLDENKDGYVSREEMVRAIDESGERSSGRIAMKRFEEMDWDKNGMVNFKEFLFAFTQWVGIDENEEEEEEDNNEKA
Protein: DNA polymerase III subunit epsilon (EC 2.7.7.7) (P03007)
Organism: Escherichia coli (strain K12)
Function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. Contacts both the beta sliding clamp (dnaN) and the polymerase subunit (dnaE), stabilizing their interaction.
Interaction partners:
- DNA polymerase III subunit tau
- DNA polymerase III subunit alpha
- DNA polymerase III subunit theta
- Beta sliding clamp
- DNA polymerase III subunit delta
- DNA polymerase III subunit psi
- DNA polymerase III subunit chi
- Ribonuclease HI
- DNA polymerase III subunit delta'
- Protein UmuD
Sequence:
MSTAITRQIVLDTETTGMNQIGAHYEGHKIIEIGAVEVVNRRLTGNNFHVYLKPDRLVDPEAFGVHGIADEFLLDKPTFAEVADEFMDYIRGAELVIHNAAFDIGFMDYEFSLLKRDIPKTNTFCKVTDSLAVARKMFPGKRNSLDALCARYEIDNSKRTLHGALLDAQILAEVYLAMTGGQTSMAFAMEGETQQQQGEATIQRIVRQASKLRVVFATDEEIAAHEARLDLVQKKGGSCLWRA
Protein: Light-induced protein, chloroplastic (Drought-induced stress protein CDSP-34) (P80471)
Organism: Solanum tuberosum (Potato)
Function: Required for normal plant growth. May be both photoprotective and play an ancillary role in photosynthesis. May structurally stabilize thylakoids during osmotic and oxidative stress.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:8717138}.
Interaction partners:
Sequence:
MASISSLNQIPCKTLQITSQYSKPTSKISTLPISSTNFPSKTELHRSISVKEFTNPKPKFTAQATNYDKEDEWGPEVEQIRPGGVAVVEEEPPKEPSEIELLKKQLADSLYGTNRGLSASSETRAEIVELITQLESKNPNPAPTEALTLLNGKWILAYTSFSGLFPLLSRGNLPLVRVEEISQTIDSESFTVQNSVVFAGPLATTSISTNAKFEVRSPKRVQIKFEEGIIGTPQLTDSIVLPENVEFLGQKIDLSPFKGLITSVQDTASSVAKSISSQPPIKFPITNNNAQSWLLTTYLDDELRISRGDAGSVFVLIKEGSPLLKP
Protein: Rho guanine nucleotide exchange factor 9 (Collybistin) (Rac/Cdc42 guanine nucleotide exchange factor 9) (Q9QX73)
Organism: Rattus norvegicus (Rat)
Function: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10607391, ECO:0000269|PubMed:11727829, ECO:0000269|PubMed:15215304}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UTH8}.
Interaction partners:
Sequence:
MQWIRGGSGMLITGDSIVSAEAVWDHVTMANRGVAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGDDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVIDIEDGRDDDFNVSMKNAFKLHNKETEEVHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKASKQKGRVGEEENQSLELKRACEVLQRLWSPGKKS
Protein: Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47) (A1A4Y4)
Organism: Homo sapiens (Human)
Function: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate pro-inflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:28389568}. Cell membrane {ECO:0000250|UniProtKB:Q60766}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q60766}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:29420192}. Lysosome membrane {ECO:0000250|UniProtKB:Q60766}. Late endosome membrane {ECO:0000250|UniProtKB:Q60766}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q60766}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q60766}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes. Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Also detected in late endosomes and lysosomes. {ECO:0000250|UniProtKB:Q60766}.; SUBCELLULAR LOCATION: [Isoform IRGMd]: Mitochondrion {ECO:0000269|PubMed:21102437}.
Interaction partners:
- Autophagy protein 5
- Ubiquitin-like-conjugating enzyme ATG10
- Autophagy-related protein 16-1
- Nucleotide-binding oligomerization domain-containing protein 2
- Beclin-1
- Endophilin-B1
- Zinc finger protein 300
- Antiviral innate immune response receptor RIG-I
- SNARE-associated protein Snapin
- Tetraspanin-8
Sequence:
MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERVCEY
Protein: Prefoldin subunit 3 (Genes involved in microtubule biogenesis protein 2) (Gim complex subunit 2) (GimC subunit 2) (P48363)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Interaction partners:
- Prefoldin subunit 4
- Prefoldin subunit 5
- Prefoldin subunit 2
- Prefoldin subunit 6
- Prefoldin subunit 1
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit delta
- Phosducin-like protein 1
Sequence:
MDTLFNSTEKNARGIPQAPFIENVNEIIKDPSDFELCFNKFQERLSKYKFMQESKLATIKQLKTRIPDLENTLKICQSLRNHSDEGDESDEPILLHYQLNDTLYTKAQVDIPEDRADLKVGLWLGADVMLEYPIDEAIELLKKKLADSEQSLTVSTEDVEFLRENITTMEVNCARLYNWDVQRRQDLKQAQEGTKNLKI