wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B) (O95096)
Organism: Homo sapiens (Human)
Function: Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Transducin-like enhancer protein 3
- Neurogenin-3
- Histone deacetylase 1
- Insulin
- LIM homeobox transcription factor 1-beta
- Paired box protein Pax-4
- Oligodendrocyte transcription factor 2
- Insulin gene enhancer protein ISL-1
- Paired box protein Pax-6
- Achaete-scute homolog 1
Sequence:
MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
Protein: Transcriptional regulator Nrg1 (Q197G0)
Organism: Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii)
Interaction partners:
Sequence:
MSTEASPHQTQHLPSSYPHHPACLPSNEPPRMPNPASSLPDAANGSHSFTADLSINSIKTEDSMSDHSAVAGQPSQPSKGKNGATGPAEGKAKPHVCPICQRGFTTGGHLQRHHRIHTGVKAFKCPFPGCETRTSRQDNLQQHYRTHLSPTLRRGSGSAARAAVNAAMEAAGLKSSSSRQPRKSKSATGTPTSATASHFPSPYATNPGPNPYAAYMYDQQHGYPPPYPLPPGVTMTQPQSAASSRVPSPVNGHSAAGSLPPAHQQSFFSQPYTPTYASYPSVHQQPPYRYPTGGIPYPAGPYSHHSLYSSSIAPEHSQHMYSPMQSSFAAHSREGSYGLSASAYGGRSPASGAYGHPRR
Protein: GEO08311p1 (RH30069p) (Q9W569)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- phospholipase A2
Sequence:
MPIDTRELMEAIAIVADERNVRVAVKQSGKGAAICAACSFAGGMLLGPVGLAVGGAAGGIAAYKMTSGTFRPLGEVILNDLTDAQREQLVQHVTMAVADIHPTDVVMLLPLIVQNASIQQAVLNTVMSFVTNELRMQIVD
Protein: ARM repeat superfamily protein (F4ILW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein NPGR1
- Protein NPGR2
- Hyccin
- At5g64090
- Protein NPG1
- Phosphatidylinositol 4-kinase alpha 2
- Phosphatidylinositol 4-kinase alpha 1
Sequence:
MSAVSGVISRQVLPVCGSLCILCPALRARSRQPVKRYKKLIAEIFPRNQEEGINDRKIGKLCEYAAKNAVRMPKISDSLEHRCYKELRNENFHSAKIAMCIYRRLLVTCKEQIPLFSSGFLRTVQALLDQTRQDEMQIVGCQSLFEFVINQKDGSSLFNLEGFLPKLCQLGLEGGDDDRSRSLRAAGLQALSAMIWLMGEYSHIPSEFDNVVSAVLENYGHPKILTNANDSGRKWVDEVLKNEGHVAYEDSLINVPSWRTVVNDKGELNVKMEDSLDPSFWSKVCLHNMAKLGEEATTMRRILESLFRNFDEGCLWSTENSIAFPVLRDLQFLMEISGQRTHFLLSMLIKHLDHKSVLKHPSMQLNILEVTSSLSETAKVEHSATIVSAISDIMRHLRKCMHSSLDEANLGTDAANCIRMVSVAVDKCLVQLTKKVGDAGPILDAMALMLENISAVTDVARTTIAAVFRTAQIIASIPNLQYQNKAFPEALFHQLLQAMVHPDHKTRIGAHRIFSVVLVPTSVCPRPSSTTTDLKKGMGLPRSLSRTASVFSSSAALFEKLKKDKFSSMLTSDHSQNGMPEEERGSSTGEILDRLKSSYRQAYSTWNQPLTSVVDNSVDLLNSELDVVHIRLSSHQIGLLLSSIWAQSISPANTPDNYEAIANTYSLVLLFSRVKNSSHDALIRSFQMALSLRDISLMEGGPLPPSRRRSLFTLAASMVLFSSKAFNLFSLADFTKVTLQGPRLDPFLNLVDDHKLKAVNSDQLKVAYGCEKDDASALDTLSNIALSTEHSRGTLVYEIVKSLEDMCNSEMDKMREQLLTEFMPDDACPLGTRFLEDTHKTYQIDSGDVKPRKEDAEDQEFGDGTETVTKNNHVTFSEIPDLLTVNQILESVVETTRQVGRISFHTAADASYKEMTLHCENLLMGKQQKISSLLNSQLRHESSVNCSPRQHDEEIKIASFHPMINSAFHTGVEVPLLSKEFDMKSPRTPVGTIQSPCYAELQNNPQAFRLPASSPYDNFLKAAGC
Protein: Uncharacterized protein ycf72 (ORF137) (Q6ENC9)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Uncharacterized protein
- 40S ribosomal protein S16
- Large ribosomal subunit protein uL4 C-terminal domain-containing protein
- Small ribosomal subunit protein eS31 domain-containing protein
- Small ribosomal subunit protein eS21
- 40S ribosomal protein S30
- Small ribosomal subunit protein uS10 domain-containing protein
- Small ribosomal subunit protein uS10 domain-containing protein
- 40S ribosomal protein S15
- 40S ribosomal protein S15
Sequence:
MGAFPSPPPWGWSTGFITTPLTTGRLPSQHLDPALPKLFWFTPTLPTCPTVAKQFWDTKRTSPDGNLKVADLPSFAISFATAPAALANCPPLPRVISMLCMAVPKGISVEVDSSFLSKNPFPNCTSFFQSIRLSRCI
Protein: Arrb2a protein (Arrestin, beta 2a) (Q6PFK2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGDKAGTRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYIFTFQAYPPIPEESKPHSRLQERLLKKLGQNAYPFHFSIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSMEEKNHKRNSVRLVIRKAQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQIEADDQVASSSTFCKVYTLTPTLNNNREKRGPALDGKLKHEDTNLASSTIVKDVSNKEVLGVLVSYRVKVKLVVSRGGDVSVELPFVLMHPKPSESSLSHSTSAVPMLDPPIDTNLIEFDTNSLIPDDDIVFEDFARLRLKGVIDKEEDC
Protein: ORF 45 (ORF45) (Q77UV9)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MAMFVRTSSSTHDEERMLPIEGAPRRRPPVKFIFPPPPLSSLPGFGRPRGYAGPTVIDMSAPDDVFAEDTPSPPATPLDLQISPDQSSGESEYDEDEEDEDEEENDDVQEEDEPEGYPADFFQPLSHLRPRPLARRAHTPKPVAVVAGRVRSSTDTAESEASMGWVSQDDGFSPAGLSPSDDEGVAILEPMAAYTGTGAYGLSPASRNSVPGTQSSPYSDPDEGPSWRPLRAAPTAIVDLTSDSDSDDSSNSPDVNNEAAFTDARHFSHQPPSSEEDGEDQGEVLSQRIGLMDVGQKRKRQSTASSGSEDVVRCQRQPNLSRKAVASVIIISSGSDTDEEPSSAVSVIVSPSSTKGHLPTQSPSTSAHSISSGSTTTAGSRCSDPTRILASTPPLCGNGAYNWPWLD
Protein: Calcium uniporter protein C-terminal domain-containing protein (Q38C29)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- EF-hand domain-containing protein
- EF-hand domain-containing protein
Sequence:
MVGTVLRVYTHRTRCIGELCSVAPLCVILEQRRPGPSFGIRSQSREDNSVHFLPCEGAVDLSLRALSTIEGLRNYREHRLRPQLLVKRAELRQADDVKTRCDALGLRYADRCIAIAVALILIRNVVLFYWVYFLFDWNLVEPITYLLERGAVCLGFLWYGATSSDARFESFRQFLVSRRTQRLYAQHNFNAGHWKELVVEVEGLEEQLRGLETV
Protein: Choline kinase (EC 2.7.1.32) (ATP:choline phosphotransferase) (P20485)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. Also exhibits ethanolamine kinase activity but it is a poor substrate at 14% efficiency compared with choline.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Choline-phosphate cytidylyltransferase
- Ethanolamine kinase
- Cyclin-dependent kinase 1
- Target of rapamycin complex 1 subunit KOG1
- Glycerophosphocholine phosphodiesterase GDE1
- SEC14 cytosolic factor
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Phosphatidylethanolamine N-methyltransferase
- Uncharacterized transporter YBR287W
- Ethanolamine-phosphate cytidylyltransferase
Sequence:
MVQESRPGSVRSYSVGYQARSRSSSQRRHSLTRQRSSQRLIRTISIESDVSNITDDDDLRAVNEGVAGVQLDVSETANKGPRRASATDVTDSLGSTSSEYIEIPFVKETLDASLPSDYLKQDILNLIQSLKISKWYNNKKIQPVAQDMNLVKISGAMTNAIFKVEYPKLPSLLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNSQRIARRMKELHVGVPLLSSERKNGSACWQKINQWLRTIEKVDQWVGDPKNIENSLLCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPSSTSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDYNNAKAPHQCHADRYPDKEQVLNFLYSYVSHLRGGAKEPIDEEVQRLYKSIIQWRPTVQLFWSLWAILQSGKLEKKEASTAITREEIGPNGKKYIIKTEPESPEEDFVENDDEPEAGVSIDTFDYMAYGRDKIAVFWGDLIGLGIITEEECKNFSSFKFLDTSYL
Protein: Muscarinic acetylcholine receptor M4 (Mm4 mAChR) (P32211)
Organism: Mus musculus (Mouse)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Kininogen-1
- HMW kininogen-II
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MANFTPVNGSSANQSVRLVTTAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPPTELSTTEAATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGSECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
Protein: Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (Q61206)
Organism: Mus musculus (Mouse)
Function: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Platelet-activating factor acetylhydrolase IB subunit beta
- Platelet-activating factor acetylhydrolase IB subunit alpha1
- Platelet-activating factor acetylhydrolase 2, cytoplasmic
- Platelet-activating factor acetylhydrolase
- Lysophosphatidylcholine acyltransferase 2
- Lysophosphatidylcholine acyltransferase 1
- Lysophospholipid acyltransferase LPCAT4
- Lysophosphatidylcholine acyltransferase 2B
- Choline/ethanolaminephosphotransferase 1
- Cholinephosphotransferase 1
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
Protein: Cell surface A33 antigen (Glycoprotein A33) (Q99795)
Organism: Homo sapiens (Human)
Function: May play a role in cell-cell recognition and signaling.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Heat shock factor protein 4
- Sterol 26-hydroxylase, mitochondrial
Sequence:
MVGKMWPVLWTLCAVRVTVDAISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNVALYVGIAVGVVAALIIIGIIIYCCCCRGKDDNTEDKEDARPNREAYEEPPEQLRELSREREEEDDYRQEEQRSTGRESPDHLDQ
Protein: HTH-type transcriptional regulator RcdA (Regulator of csgD) (P75811)
Organism: Escherichia coli (strain K12)
Function: Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators: csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes.
Interaction partners:
- Inner membrane protein YbjJ
- 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
- Elongation factor Tu 2
- DNA topoisomerase 4 subunit A
- 5-amino-6-
- Uncharacterized protein YciQ
- Cold shock-like protein CspC
- Elongation factor Tu 1
- Cell division topological specificity factor
- Uncharacterized protein YaeQ
Sequence:
MRRANDPQRREKIIQATLEAVKLYGIHAVTHRKIATLAGVPLGSMTYYFSGIDELLLEAFSSFTEIMSRQYQAFFSDVSDAPGACQAITDMIYSSQVATPDNMELMYQLYALASRKPLLKTVMQNWMQRSQQTLEQWFEPGTARALDAFIEGMTLHFVTDRKPLSREEILRMVERVAG
Protein: Mitochondrial membrane protein FMP33 (P46998)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
Interaction partners:
- Putative uncharacterized protein YJL009W
- Uncharacterized protein YJL028W
- Uncharacterized protein YJL027C
- Uncharacterized protein YJR056C
- Protein HIT1
- VPS10 homolog 2
Sequence:
MLYTRLLRHNSQFTKFSGTSPNLGSKPLFSKGNLYTSLLVTTLYGTGLACLYLESNSLNKSKEQEDPHAIAEDDIVNIVHDAPNRIFKPALDTYQEKELDLQKSDLHKVLHSLTYSDVSQFSIVWGFLIQLSSLIGNSTLGKKSILYKGSVVSVLGFPPLIYMALKLRMKQLEKAGVRFE
Protein: Glycosyltransferase (Q9HTB4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Methyltransferase type 11 domain-containing protein
- Class I SAM-dependent methyltransferase
- Acyltransferase 3 domain-containing protein
- Glycosyltransferase WbpX
- Glycosyltransferase
- ABC subunit of A-band LPS efflux transporter
- D-rhamnosyltransferase WbpZ
- GDP-6-deoxy-D-mannose reductase
- Alginate biosynthesis protein AlgA
- DUF1127 domain-containing protein
Sequence:
MLIIIHSETNKTTIRQNLGRPEYSYYFVLKEFRPLLEEIGQVVEVSDPDELVDRLYHDCRKRGEPCVFLSFSPPHRTPIHHACPTIPVFAWEFSTLPSETWHGEPRHDWRHVLRHSGRAITHSSFTVDVVRAAMGRDYPVLSVPAPVWDRFANRASQQAGRPEARDVRLRLDGLLVDSRQLDLAVHADPEPSAEVLALPDRAAKQVELSLDGVIYTSVFNPYDGRKNWQDMISAFCATFRDEPDATLVLKLTHHNVGEALADMLHHLYKNQSYRCRIVLIHGYLADPDYERLVEATSYVVNTSYGEGQCLPLMEFMSSGKPAVAPRNTAMIDYIDADNAFIVDSSEEATAWPHDPRAAYRTLRYITDWESLCRAYRASFEVARQEPERYARMSAHASASLERFCSRKLAVERLRRFFDEAAQGDPSALQSIPA
Protein: Cytosolic heat shock protein 90 (Q7XJ80)
Organism: Hordeum vulgare (Barley)
Interaction partners:
Sequence:
MATETETFAFQAEINQLLSLIINTFYSNKEIFLRELISNSSDALDKIRFESLTDKSKLDAQPELFIHIIPDKATSTLTIVDSGIGMTKSDLVNNLGTIARSGTKEFMEALAAGADVSMIGQFGVGFYSAYLVAERVVVTTKHNDDEQYVWESQAGGSFTVTRDTSGEQLGRGTKMVLYLKDDQMEYLEERRIKDLVKKHSEFISYPISLWTEKTTEKEISDDEDEEEKKDTEEGKVEDVDEEKEEKEKKKKKIKEVSHEWNLVNKQKPIWMRKPEEINKEEYAAFYKSLTNDWEEHLAVKHFSVEGQLEFKAVLFVPKRAPFDLFDNKKKANNIKLYVRRVFIMDNCDELIPEYLSFVKGIVDSEDLPLNISRETLQQNKILKVIRKNLVKKCIELFFEIAENKEDYNKFYEAFSKNLKLGIHEDSQNRTKIAELLRYHSTKSGDELTSLKDYVTRMKEGQNEIYYITGESKKAVENSPFLEKLKKKGYEVIYMVDAIDEYAIGQLKEFEGKKLVSATKEGLKLDESEDEKKKQEELKEKFEGLCKVIKEVLGDKVEKVIVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDSSMAGYMSSKKTMEINPENAIMDELRKRADADKNDKSVKDLVMLLFETSLLTSGFSLEDPNTFGTRIHRMLKLGLSIDEDDEAPENDTDMPPLEDDAGESKMEEVD
Protein: Glutathione reductase (GR) (GRase) (EC 1.8.1.7) (P70619)
Organism: Rattus norvegicus (Rat)
Function: Maintains high levels of reduced glutathione in the cytosol.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P00390}. Cytoplasm {ECO:0000250|UniProtKB:P00390}.
Interaction partners:
- Glutathione synthetase
- Glutathione peroxidase
- Glutathione peroxidase 1
- Glutathione peroxidase 2
- Epididymal secretory glutathione peroxidase
- Glutathione peroxidase 6
- Glutathione peroxidase
- Glutathione peroxidase 3
- Glutathione hydrolase 7
- Glutathione hydrolase 6
Sequence:
VNVGCVPKKVMWNTAVHSEFIHDHVDYGFQNCKSKFNWHVIKEKRDAYVSRLNNIYQNNLTKSHIEVIHGYATFRDGPQPTAEVNGKKFTAPHILIATGGVPTVPHENQIPGASLGITSDGFFQLEDLPSRSVIVGAGYIAVEIAGILSALGSKTSLMIRHDKVLRSFDSLISSNCTEELENAGGVEVLTVKKFSQVKEVKKTSSGLELHVVTALPGRKPTVTTIPDVDCLLWAIGRDPNSKGLNLNKLGIQTDDKGHILVDEFQNTNVKGVYAVGDVCGKALLTPVAIAAGRKLAHRLFEGKEDSRLDYDNIPTVVFSHPPIGTVGLTEDEAVHKYGKDNVKIYSTAFTPMYHAVTTRKTKCVMKMVCANKEEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNRVAIHPTSSEELVTLR
Protein: Homeobox protein ARX (Aristaless-related homeobox) (O35085)
Organism: Mus musculus (Mouse)
Function: Transcription factor (By similarity). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (By similarity). Positively modulates transcription of KDM5C. Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). Required for normal brain development. Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain. May also be involved in axonal guidance in the floor plate.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
Sequence:
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRADQEKAMQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELSGPGGVAHPEERLSAASGPGSAPAAGGGTGAEDDEEELLEDEEDEEEEEELLEDDDEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
Protein: Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Q5XIC0)
Organism: Rattus norvegicus (Rat)
Function: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.
Subcellular location: Peroxisome matrix {ECO:0000269|PubMed:11781327}. Mitochondrion {ECO:0000269|PubMed:11781327}.
Interaction partners:
- Enoyl-CoA delta isomerase 1, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase A, peroxisomal
- Peroxisomal bifunctional enzyme
- Acetyl-CoA acetyltransferase 2-like 1
- Peroxisomal acyl-coenzyme A oxidase 1
- Acetyl-CoA acetyltransferase, mitochondrial
- Cocaine- and amphetamine-regulated transcript protein
- Acetyl-CoA acetyltransferase, cytosolic
Sequence:
MAAVTWSRARCWCPSLLQVLRLPVTKLHLGRPAMRATQQDFENAMNQVKLLKKDPGNEVKLRLYALYKQATEGPCTMPKPGVFDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEASSQGKGGADGKAQESKGILVTSEGGITKITFNRPSKKNAITFQMYQDIILALKNASTDDTVITVFTGAGDYYSSGNDLTNFTSASGGMEEAANKGAIVLREFVNTFIDFPKPLVAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNSMRISKELIRKNEKEKLHAVNEEECTTLRARWLSEECINAIMSFVTRKPKL
Protein: Non-specific lipid transfer protein GPI-anchored 20 (AtLTPG-20) (Protein LTP-GPI-ANCHORED 20) (Q9LJ85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable lipid transfer protein.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Non-specific lipid transfer protein GPI-anchored 7
- Non-specific lipid transfer protein GPI-anchored 30
- At4g33550
- Protein PELPK1
- At3g53980
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- At1g12090/T28K15.14
- Glycine-rich cell wall protein-like protein
- At5g05960
Sequence:
MSKIISLVVAMIAVLALPIRGQQQPLSQCTPSMMTTVSPCMGFITNSSSNGTSPSSDCCNSLRSLTTGGMGCLCLIVTGTVPFNIPINRTTAVSLPRACNMPRVPLQCQANIAPAAAPGPAATFGPSMSPGPETDPIVPEPTPAAQTPQSDTTRPFTPSVDGGAPTSDDGGSTSRPSETPSSAYALSPSLLFFSIALVALKFY
Protein: Anthrax toxin receptor (A0A8I6A6B8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MVAGRSRARSPGSWLFPGLWLLTVGGPGSLLQAQEQPSCKKAFDLYFVLDKSGSVANNWIEIYNFVHQLTERFVSPEMRLSFIVFSSQATIILPLTGDRYKISKGLEDLKAVQPVGETYIHEGLKLANEQIQNAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKKSRSLGASVYCVGVLDFEQAQLERIADSKDQVFPVKGGFQALKGIINSILAQSCTEILELSPSSVCVGETFQVVLSGRAVMSIRDDGSVLCTFTANSTYTKNEKPVSVQPGSILCPAPVLNKAGETLEVSIAFNDGKSAVSRSLTITATECSNGIAAIIAILVLLLLLGAALMWWFWPLCCKVVIKDPPPPPSPPKEEEPLPNKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVMIPEEEIPVPSRPPRPKPTHQAPQTKWYTPIKGRLDALWALILKQYDRVSLMRPQEGDEGRCINFSRVPHQ
Protein: Cytoplasmic polyadenylation element-binding protein (CPE-binding protein) (CPEB) (Q967R6)
Organism: Aplysia californica (California sea hare)
Function: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation. In its amyloid-like oligomeric form, acts as a translational activator. Up-regulated at activated synapses where it is required for the late phase of memory-related long-term synaptic facilitation. Sustained CPEB-mediated protein synthesis for at least 72 hours after neuronal stimulation is required for the persistance of synaptic facilitation. Activates translation of atypical protein kinase C. Required for the relocalization of syntaxin mRNA to the axon hillock from the opposite pole in the cell body of sensory neurons during long-term facilitation.
Subcellular location: Synapse, synaptosome {ECO:0000269|PubMed:12480159}. Cytoplasmic granule {ECO:0000269|PubMed:19887896}. Note=In sensory neurons, detected in cytoplasmic granules composed of proteins and RNA. {ECO:0000269|PubMed:19887896}.
Interaction partners:
Sequence:
MSQSPQTVDQAISVKTDYEDNQQEHIPSNFEIFRRINALLDNSLEANNVSCSQSQSQQQQQQTQQQQQQQQQQQQQQHLQQVQQQQLLKQQQQQAQQQQIQQQLLQQQQQKQQLQQQQQQEQLQQQQLQLQQQLQQQLQHIQKEPSSHTYTPGPSPELQSVLNYANVPLSKSAAFNCNNSSSYSVGPTPVQSPVTPSPAASAVTVNSPSYGNFQLFGENAFDSTTPFQSDGTSQSHSRSLANDSDPMVVMSPGRDSIIPLSPTEKILYQNFLLSKQAQGENTALPPSPPHEIMPLSPLEKKLYSNLLSKHTQGMRAINSTSPLQTPLTPPRSPQEVLYASMPAAQVGESSSVIDMMSRMDLSGRNQQADYSGTLAFLDAHNVLRRRTPSSSRSRSVMERSAPSSYFANLDPYAIDRAARLHRNAAAVGEASCTWSGHLPPRNHENPVYSPKVFLGGVPWDITESGLQAAFSKYGHLKIEWPGKDGYVHLLFDVEKSVRSLLQACTHDFSNGDYFYKISSRRMRSKEVQVIPWVLADSNHVFQPSQRLESNKTVFVGALHGMITAEALGRIMSDLFGNVVYAGIDTDKHKYPIGSGRVTFSSRKSYMKAVQAAFVEIKTPKFTKKLQVDPYLGDAICSLCNSHQGNYFCRDLLCFKYLCRSCWYWQHAPDSMRQHRPLTRNTKSSLSL
Protein: Olfactory receptor 8K3 (Olfactory receptor OR11-181) (Q8NH51)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MEQHNLTTVNEFILTGITDIAELQAPLFALFLMIYVISVMGNLGMIVLTKLDSRLQTPMYFFLRHLAFMDLGYSTTVGPKMLVNFVVDKNIISYYFCATQLAFFLVFIGSELFILSAMSYDLYVAICNPLLYTVIMSRRVCQVLVAIPYLYCTFISLLVTIKIFTLSFCGYNVISHFYCDSLPLLPLLCSNTHEIELIILIFAAIDLISSLLIVLLSYLLILVAILRMNSAGRQKAFSTCGAHLTVVIVFYGTLLFMYVQPKSSHSFDTDKVASIFYTLVIPMLNPLIYSLRNKDVKYALRRTWNNLCNIFV
Protein: Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (CLICK-I and II-related) (CLr) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) (Q8BWQ5)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16684769}. Nucleus {ECO:0000269|PubMed:16684769}.
Interaction partners:
Sequence:
MPAAPVLRPPPPPATPAPPAPSRPAPPIPGHRGPCDHSLKCLSSKISERKLPGPWLPAGRGPLEKPVLGPRGAVMPLFSPQSSLHSVRAEHSPLKPRVVTVVKLGGQPLRKATLLLNRRSVQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLKSIQLAMEELYPKNRALALAPHSRVPSPRLRSRLPSKLLKGSHRCGEAGSYSAEMESKAVSRHQGKTSTVLAPEDKARAQKWVRGKQESEPGGPPSPGAATQEETHASGEKHLGVEIEKTSGEIVRCEKCKRERELQLGLQREPCPLGTSELDLGRAQKRDSEKLVRTKSCRRPSEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSESQDSHPQGAPKAQKDLVEGPPAVEEGPIDMRREDRHTCRSKHAAWLRREQQAEPPQLPRTRGEEKQAEHEKKPGGLGERRAPEKESKRKLEEKRPERPSGRKPRPKGIISADVEKHYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQHPWIEMVGHTNTGNSQKEESPNS
Protein: GH02222p (Q8MSK6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSWLISAVFLLLSLCAFSMGQDTISAMCLSDERCTSLKRCEDSDDSGRRGIRPRSSRICGTQRVCCEKAQLDSYDRWLVERTTTVPSTIRNKVSSVLEPPPNESCGQNMECVPRKLCRDNIINDSGISLINPRISPIQCSKSLYRCCAVDQKVDDSESPYLVKQANFKYKNCGYSNPKGLIPDNDKFPYSEDVSIFGEFPWMVGIFTGRQEFLCGGTLIHPRLVVTTSHNLVNETVDTLVARAGDWDLNSLNEPYPHQGSRIKEIIMHSEFDPNSLYNDIALLLLDEPIRLAPHIQPLCLPPPESPELTNQLLSVTCYATGWGTKEAGSDKLEHVLKRINLPLVEREECQAKLRNTRLRLASDCDRVSSAPAEILARTPARATAAHRFSAKCLAKWIGTSWWASCPGASSAPWKTFRRCTSTCPICAAGLTRRSEDLESCCRRNKLKP