wanglab/gogpt-training-data huggingface dataset:
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (Q5HV33)
Organism: Campylobacter jejuni (strain RM1221)
Function: Acts as a chaperone.
Interaction partners:
Sequence:
MSKVIGIDLGTTNSCVAVYERGESKVIPNKEGKNTTPSVVAFTDKGEVLVGDSAKRQAVTNPEKTIYSIKRIMGLMINEDAAKEAKNRLPYHITERNGACAIEIAGKIYTPQEISAKVLMKLKEDAEAFLGESVVDAVITVPAYFNDAQRKATKEAGTIAGLNVLRIINEPTSAALAYGLDKKDSEKIVVYDLGGGTFDVTVLETGDNVVEVLATGGNAFLGGDDFDNKLIDFLANEFKDETGIDLKNDVMALQRLKEAAENAKKELSSANETEINLPFITADASGPKHLVKKLTRAKFEGMIDSLVAETITKINEVVSDAGLKKDEIKEIVMVGGSTRVPLVQEEVKKAFNKDLNKSVNPDEVVAIGAAIQGAVIKGDVKDVLLLDVTPLSLGIETLGGVMTKIIEKGTTIPTKKEQVFSTAEDNQSAVTINVLQGEREFSRDNKSLGNFNLEGIPPAPRGMPQIEVTFDIDANGILTVSAKDKATGKAQEIKITGSSGLSEEEINNMVKDAELHKEEDKKRKEAVDARNAADSLAHQVEKSLSELGEKVAAADKENIQKALDDLRETLKNQNASKEEIESKMKALSEVSHKLAENMYKKDEPNTANDKKKKDDDVIDAEVE
Protein: Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1) (Q01713)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13886}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
- Progesterone receptor
Sequence:
MSAAAYMDFVAAQCLVSISNRAAVPEHGGAPDAERLRLPEREVTKEHGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQTPSVCSDSLESPDEDIGSDSDVTTESGSSPSHSPEERQDSGSAPSPLSLLHSGVASKGKHASEKRHKCPYSGCGKVYGKSSHLKAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHLTKHARRHTDFHPSMIKRSKKALASPL
Protein: Putative eukaryotic translation initiation factor 3 subunit 8 (Q4Q055)
Organism: Leishmania major
Interaction partners:
- 40S ribosomal protein S3
- Putative eukaryotic translation initiation factor 1A
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Translation initiation factor-like protein
- Eukaryotic translation initiation factor 3 subunit E
- Putative 40S ribosomal protein S27-1
- RRM domain-containing protein
- Helicase-associated domain-containing protein
- Uncharacterized protein
- CSN8/PSMD8/EIF3K domain-containing protein
Sequence:
MNFFAISSSDSDSESEKSLLREEVSEAQINPFWFEWTDEEELEERQEVIPKKEKAANSIQALCDTFDYNAGNESWREALEAFKRMCDEVHTFVRKYKVAPQGLQNCLQDMPNLAEHLEGKGREDFANRLEFKSLKELVALVEETEKLYKKELEELAKGPENDDGAQDEDEDAGAELTEAEYAQILEDISGSREVNLVGKVEKVIRACARKGYTNLEISAMGIAVSAVLRRDSRKLLVSSDTWERAFKWGAKFFSRMIAATNVRFVEDSSSVNARNIVVPGGIHGFLTYLHTELVNKSKFEEVASQEYLKIITFENELAVLADRALGYYQARKRIEPSKACISILFDILGQRRQEAHQLFYDSLSSTDSLTIISKSVFDTVRALHKLSLQLRPSVALSASGVCHVAYQYGLRGLYREGRDYLLRTGVVNSIAVSDAPLAILLNRAIAQLGLAAFIAGDIPTAHQLLRTIWGLRSNQVLIGQSPPPKSVLDDEHAEMEYRNLLLPPHMHMPVAQLELASVLSGLLMGVKMEAQNPYERNHMERYVYNTVTRTPDLMGKPFSFKEQVAVAYEHLKAGNYIGAKEQVEAMTTFDTLPLGKETRKRYLQRLKEVALLVFCYTNRTNFSTMSVVNLAIKFDMEESDVRRAVNEILSENTTLSAYWDRDDAYLYLDRNNATRLQHLVKGTSESISNLAKHCESRLRANGGRGRGRGGMAGGRGGAGVRGAGGRGRGSR
Protein: Novel protein similar to vertebrate Ras family (RAB11a, member RAS oncogene family) (Rab11a protein) (Ras-related protein Rab-11A (EC 3.6.5.2)) (Q5U3E1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Myosin VB
- RAB3A-interacting protein
- RAB11 family-interacting protein 5a
- Rab11 family-interacting protein 2
- RAB11 family-interacting protein 1
- RAB11 family-interacting protein 1
- Phosphatidylinositol 4-kinase beta
- Rab11 family-interacting protein 3
- Rab11 family-interacting protein 5-like
- Rhodopsin
Sequence:
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFLETSALDSTNVETAFQTILTEIYRIVSQKQMSDRRDNDMSPSNNVVSIQVQPTENKPKMQCCQSI
Protein: Major outer membrane lipoprotein (Outer membrane lipoprotein I) (P11221)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane; Lipid-anchor.
Interaction partners:
- Outer membrane porin F
- Peptidoglycan-associated lipoprotein
- B-type flagellin
- Type III secretion protein PcrV
- Exotoxin A
- DNA-binding protein HU-beta
- Outer membrane protein OprG
- Glycine zipper 2TM domain-containing protein
- Azurin
- Porin D
Sequence:
MNNVLKFSALALAAVLATGCSSHSKETEARLTATEDAAARAQARADEAYRKADEALGAAQKAQQTADEANERALRMLEKASRK
Protein: SPX domain-containing protein 1 (Protein SPX DOMAIN GENE 1) (OsSPX1) (Q69XJ0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in plant adaptation to phosphate (Pi) starvation. Inhibits PHR2 DNA-binding activity via a Pi-dependent protein interaction. Suppresses the regulation on expression of PT2 by PHR2 and accumulation of shoot Pi. Optimizes growth under phosphate-limited conditions through a negative feedback loop of the PSI (phosphate starvation-induced) signaling pathway. Regulates the expression of SPX2, SPX3 and SPX5. May be an important link between signal transduction pathways related to phosphate starvation and cold stress. Together with SPX2, plays a negative role in the regulation of leaf inclination by preventing RLI1 transcription factor activity in Pi depleted conditions.
Subcellular location: Nucleus {ECO:0000269|PubMed:19566645, ECO:0000269|PubMed:25271318}.
Interaction partners:
- Protein PHOSPHATE STARVATION RESPONSE 2
- Protein PHOSPHATE STARVATION RESPONSE 1
Sequence:
MKFGKSLSSQIVETLPEWRDKFLSYKDLKKRLKLIGGGGGGEERQAKRARVAADGGEEEAAAAAMTPEEAGFMRLLEAELDKFNSFFVEKEEEYIIRQKELQDRVARAAGRESKEELMRVRKEIVDFHGEMVLLENYSALNYTGLVKILKKYDKRTGALIRLPFIQKVLQQPFFTTDLLYKLVKQCEAMLDQLLPSNELSVSSEDGRGDSTNEDKPSNPSSSLVNGGTIPELDEIEYMESMYMKGTVAALRSLKEIRSGSSTVSAFSLPPLQGDSSPEEQQELWNKIPVIEQAAK
Protein: Olfactory receptor 4M1 (Olfactory receptor 734) (Q8VFT4)
Organism: Mus musculus (Mouse)
Function: Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release. Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity. In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP.
Subcellular location: Cell membrane {ECO:0000269|PubMed:31230984}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU363047}.
Interaction partners:
- Fibrillin-1
- Guanine nucleotide-binding protein G
Sequence:
MEPANDTTVTEFILTGLSQTREVQLVLFVIFLSFYLFILPVNILIICTIRLDSHLSSPMYFLLANLAFLDIWYSSITAPKMLVDFFVERKIISFGGCIAQLFFLHFVGASEMFLLTVMAFDRYAAICRPLHYATIMNRRLCCILVALSWTGGFVHSIIQVALIVRLPFCGPNELDNYFCDITQVVRIACANTFLEEMVMIFSSGLISVVCFIALLMSYAFLLTMLKKHSSSGESTSRAISTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFHTVIFPLLNPIIYTLRNKEVKAAMRKLVNRYIFCKEK
Protein: Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.7) (Cation transport regulatory protein ChaC) (P39163)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Interaction partners:
- Glutathione S-transferase GstB
- Glutathione S-transferase YfcF
- Glutathione synthetase
- Thioredoxin/glutathione peroxidase BtuE
- Glutathione hydrolase proenzyme
- Aminopeptidase N
- 5-oxoprolinase subunit B
- Glutathione S-transferase GstA
- 5-oxoprolinase subunit A
- 5-oxoprolinase subunit C
Sequence:
MITRDFLMNADCKTAFGAIEESLLWSAEQRAASLAATLACRPDEGPVWIFGYGSLMWNPALEFTESCTGTLVGWHRAFCLRLTAGRGTAHQPGRMLALKEGGRTTGVAYRLPEETLEQELTLLWKREMITGCYLPTWCQLDLDDGRTVNAIVFIMDPRHPEYESDTRAQVIAPLIAAASGPLGTNAQYLFSLEQELIKLGMQDDGLNDLLVSVKKLLAENFPDGVLRPGFA
Protein: Methylcrotonyl-CoA carboxylase subunit 1 (E9PHF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDKRESE
Protein: Protein root UVB sensitive 2, chloroplastic (Protein WEAK AUXIN RESPONSE 1) (Q9SJX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in a root UV-B sensing pathway and in the protection against the hypersensitivity to very low-fluence-rate (VLF) UV-B. RSU1 and RUS2 are probably both negative modulators of the same UV-B perception pathway, which when overstimulated in the roots causes a block to postgermination development. Required for polar auxin transport and to maintain the normal levels of PIN proteins in the root.
Subcellular location: Plastid {ECO:0000269|PubMed:20562234, ECO:0000303|PubMed:19515790}. Note=May be localized to the plastid as a consequence of its interaction with RUS1. {ECO:0000303|PubMed:19515790}.
Interaction partners:
- Aspartate aminotransferase, cytoplasmic isozyme 1
Sequence:
MQFLQEKVKLIKKEDPVMLKSPEDFPVYWFETSDSVSHRYQFQSDGHLSMKVVDDARPVPQKMVESFLNKFFPSGYPYSVNEGYLRYTQFRALQHFSSAALSVLSTQSLLFAAGLRPTPAQATVVSWILKDGMQHVGKLICSNLGARMDSEPKRWRILADVLYDLGTGLELVSPLCPHLFLEMAGLGNFAKGMATVAARATRLPIYSSFAKEGNLSDIFAKGEAISTLFNVAGIGAGIQLASTICSSMEGKLVVGSILSVVHVYSVVEQMRGVPINTLNPQRTALIVANFLKTGKVPSPPDLRFQEDLMFPERPIQDAGNVKVGRALHKAVKPSEVQRLKQVFVEEKFLLSHGKSWTDMVLEHDATGEDALRGWLVAAYVKSMTKIYNDPDDIILQDAYDKMNDVFNPFLSQVQAKGWYTDRFLDGTGTRFAW
Protein: Lysophospholipase-like protein 1 (EC 3.1.2.22) (Q5VWZ2)
Organism: Homo sapiens (Human)
Function: Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
Subcellular location: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.
Interaction partners:
- Protein phosphatase 1 regulatory subunit 3B
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Transmembrane 6 superfamily member 2
Sequence:
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
Protein: X-ray repair cross complementing 6 (B1AHC9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKKQRKNKKRTLKQVCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQD
Protein: Probable proteasome subunit beta type-1 (EC 3.4.25.1) (O43063)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable proteasome subunit beta type-7
- Probable proteasome subunit alpha type-3
- Probable proteasome subunit beta type-2
- Probable proteasome subunit beta type-4
- Probable proteasome subunit beta type-3
- Probable proteasome subunit alpha type-5
- Probable proteasome subunit alpha type-2
- Probable proteasome subunit alpha type-7
- Probable proteasome subunit alpha type-1
- Probable proteasome subunit alpha type-6
Sequence:
MATTVKDTMNVDINAIKKGEIRMGTTITALRYKDGVILAADSRTTMGAYIANRVTDKLTQLTDNIWCCRSGSAADTQTVADLLKYYLSMYRIQFGHDPSVHTAATLASEMCYQNKNMLSAGLIVAGYDEKTGGDVYSIPLGGSLHKQPLAIGGSGSAFIYGFCDANFRENMTQEEAVEFLKNAVALAMERDGSSGGTIRMVILNKDGMERKFFAIDTANPIPVFTH
Protein: Peroxisomal ATPase pex1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis protein pex1) (O74941)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the pex1-pex6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the pex5 receptor from peroxisomal membranes, an essential step for pex5 recycling. Specifically recognizes pex5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the pex2-pex10-pex12 retrotranslocation channel. Extraction by the pex1-pex6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from pex5.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}. Peroxisome membrane {ECO:0000250|UniProtKB:P24004}; Peripheral membrane protein {ECO:0000250|UniProtKB:P24004}; Cytoplasmic side {ECO:0000250|UniProtKB:P24004}.
Interaction partners:
- Peroxisomal ATPase pex6
- Peroxisomal membrane protein pex13
- Peroxisomal targeting signal receptor
- Peroxisome assembly protein 12
- Peroxisomal membrane protein pex14
Sequence:
MRCIVSYKSLRSCLVNVPELLLESISEPVQNYAVQAVVCKNDIKKTFYFGISGIPSQFSFEIDSTYAHTLKLAENQEINLSIIDCTHEIEQLEIEPVTSNDWEIAERNAAWLEENLLVQYRVATTERFIIYLPSGTFIQFQPLKLIPSSLCGRLLRTTEVLITPKPNTSAIEVKENRKVNLRCVVENRLLPDSVTADSPALCVFLPLNFPDRPDVVYMDGGNLKSTIVCQCVSCPFQIPGHFFISKSLALSYSIKTGFKFQIWKAHNPPSSSKFILEQKGLPPESNLSSELVAAKLKNSYLMDGMTLKLVDIAVSYSVSGLSGVVKNPIQDIKITSDTNVPVNAGIRNNSPRLSMQPFPHEFAQVRNAVFLHQNIYINGPKGCGKSNLVHSLFDYYSLNSIYFQMIVSCSEIDRSSFAKFQSFWNNVFIQAERYEPSIIYLDDVHCLISSSNENGELGFVEEREIAFLQHQIINLKRKRKIIFIGFGEEFLTFSENLVLPLLFQIKIALPSLAVTRRKEILTTIFQENFSDITMDSIEFISVKTEGYLMTDLVLFVKRLLSEAFVEKIQNGPKHLMNKGLIEKTLKDFVPLQLRKAKFVKSSIRWIDIAGMQEAKEAVRDIIESPVKYSLIYKQCRLRLPTGILLFGYPGCGKTYLASAISSTFPVQFISIKGPELLDKYIGKSEQGVRDLFSRAQMAKPCVLFFDEFDSVAPRRGQDSTGVTDRVVNQILTQMDGAESLDGVYIVAATTRPDMIDPALLRPGRLDKLIFCDLPNEEERLEVLQKLANRFHIENAAMLKKLSTLTDGYTYADLSSLLYDAHLIAVHKLLKRVSINAVDPSQTTSSFTNLTTESKRNASMLALPPESRYNQNMQSMSDSKSVVIEDYMLMEALKKNSPSLNSEEFEHLSNLYRDFRSKLFEPELNARNTDVGSKTRQI
Protein: Histone H2A variant 1 (H2A.F/Z 1) (H2AvAt) (HTA11) (O23628)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Variant histone H2A which may replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Histone H4
- SWR1 complex subunit 6
- SWR1 complex subunit 2
- SWR1-complex protein 4
- Histone H2B.6
- Histone H3-like centromeric protein CENH3
- Histone H3.1
- RuvB-like protein 1
- Actin-related protein 6
Sequence:
MAGKGGKGLVAAKTMAANKDKDKDKKKPISRSARAGIQFPVGRIHRQLKTRVSAHGRVGATAAVYTASILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDTLIKGTIAGGGVIPHIHKSLINKTTKE
Protein: Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) (Q9BXL6)
Organism: Homo sapiens (Human)
Function: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21302310}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21302310}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21302310}.
Interaction partners:
- B-cell lymphoma/leukemia 10
- Caspase recruitment domain-containing protein 10
- Protein kinase C theta type
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
- Caspase recruitment domain-containing protein 11
- Protein kinase C beta type
- Alpha/beta-tubulin-N-acetyltransferase 9
- Interleukin-36 receptor antagonist protein
- AP-1 complex subunit sigma-3
- Nucleotide-binding oligomerization domain-containing protein 2
Sequence:
MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVRPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR
Protein: Angiotensin-converting enzyme (EC 3.4.-.-) (D8WU01)
Organism: Rousettus leschenaultii (Leschenault's rousette) (Pteropus leschenaultii)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|PROSITE-ProRule:PRU01354}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|PROSITE-ProRule:PRU01354}. Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLGSFWFLLSLVAVTAAQSTPEELAKTFLEKFNTEAEDLFYQSSLASWDFNTNIIDENVQKMSKARATWSAFYDEQSKLAKTYQLDEIQDPELKLQLRILQQSGSSTLSADKTKRLNDILNTMSTIYSTGKICQPNNSQECLLLEPGLDDIMENSKDYSQRLWAWESWRSEVGKQLRPYYEEYVVLKNEMARGENYEDYGDYWRGDYETEGINGSAYTRDQLIEDVDRIFTEIKPLYEQLHAYVRTKLMDAYPSHISPTGCLPAHLLGDMWGRFWINLYPLTVPFEQKPNIDVTDEMVNQNWNAKRIFKEAEKFFVSLGLPNMTETFWEKSVLTEPDNDQKVACHPTAWDLGKGDFRIIMCTKVKMEDFLTAHHEMGHIQYYMAYATQPYLLRDGANEGFHEAVGEVISLSVATPNHLKNMGLLPPDFYEDNETEINFLLKQALNVVGTLPFTYMLEKWRWMVFKGEIPKEQWMEKWWEMKRELVGVVEPLPHDETYCDPASLFHVANDYSFIRYYTRTIFEFQFLEALCQIAQHEGPLYKCDIANSTEAGKKLHQMLSLGKSKPWTLALESIAGTKNMDVRPLLNYFEPLFTWLKEKNRNSFVGWSTDWSPYSGQSIKVRISLKAALGEKAYEWNDNEMYLFKSSIAYSLREYFLKVKNLTIPFGEEDVWVSDLKPRISFNFFVTSPQNVSEFIPRTEVEGAIRMSRSRINDAFRLDDDTLEFLGIEPTLGTPYQPPVTIWLIVFGVVMGLVVVGIVLLIFVGIRDRRKKNQERSEENPYSSVDLSKGENNAGFQNNDDVQTSF
Protein: ENL/AF9-related, isoform A (ENL/AF9-related, isoform C) (FI01302p) (Q9VF92)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
Interaction partners:
Sequence:
MAVKVQFEIGHTSKLRSKKTPHPQAFTHDWEIYVQGVNKADISAFVEKVVFVLHESFPKPKRVVKEPPYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTGPPQHHVEVKTHIFEAPSEEFRTKLMRGGGVPVFGANIGAGSLARTLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGKKHKSRSEDPGKSNAFSALFGPPITKTSVTANNMAQVPVSKHSPEAKSAAVGGKGVFHEGREKASKDRDKSSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSKKDKSRDKEREREQGSGNTTSANALTVATSVGTAGGLVKHTASPKPGKPNEMGAPSPKKTANDSAAGAVAPTSRSKERDEHKSVKSESKDKERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQSDSPASGNLQSAHLQQQSQVASTGKATPTSVGSNSSSSMVSNIGKQKEEATGKHSEKAAESKGDKSTSNGNATDTKKSHKHKKKEKSKDKEKERNDRDKDKDKERDKDKLKEREKDKQHVTGSEKSSTVDPSPKLEGASPATEGGAPDKTPVSASASSGSKKEKHKKSKEKSSGKDEKRQREAVDKQADTKHTGKSQQSQSGQSKTPSNLDLSDMDSAQSAPDLAATNALAAAAAATLQHSDSSNSSFPDLPARSSSQQKPTKGNTGSGKETKSTVKEHKGKSKQNDKTLEKNTDKTEKPDKTPDPKVDKSEKSEKEDKKRNRRSSQSSNSGSGAGVTGAFIEPPVKASKKEQGKAAGEKSKSPSLRPPRETNSTGTGGGTPNAGAGFLAPPSSSPSNNHSAAVAASLNNNNNNNNNNTNSNSSHSPGEMTTPGQLQLPTEYLSELQELHHKIMTLQDNEELQHVVEMIAATGCYEITHKTFDFDLCKLDRGTVQRLQEFLATSVS
Protein: Myb domain-containing protein (Q54UZ8)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSIENSNVQPTRKKGAKILNLWKGEQDILNYSGLSRRSIAALKNKEILENNNDSDSDNNNNKNKKSTKSKNSKKSNLSGEDSENDDNDVEKDENENNDVEMKDEEEEEEEEEELEEEEEEDDSEDSDDLSKKSRGRPKASVSKPPPPKVPKSKPIAKTNNKKNSNTKEVIIKEKSKITTTTTTTTTATTTATITPPPPKPVSKPVGKPKGSVSKKAAALAKKKNNVQSESEESEESESESEEDEEEEEEKGANKNKKKNEKENQVKGEGEDDDNEKEEDGENNTIDESDDEIDKFKQMDPIERIKKEYSIEKILDKRYIKPNKDDNNNNNNNNNNNNNNNNNNNNNNNNNNEEILEVLVKWKDLSYIHSSWINSKLMNQTRSSKMRLQRFIQKNIENEDNSDLLVSSTQPSWEEFTEVEKVLDVRTVSVTSNKFKADKQYLIKWKSISYSLSTWEYQDDFKDDLKIEQYYKLNEMPSKEELRDKPRPPRTAWKKIDQSPDYFTKGNKLRPYQLEGLNWLSFCWHEQRNSILGDEMGLGKTVQSVSILETLRKVHGIRGPFLVVAPLTTIPHWKREFENWTDMNALVYHDSGAGRPICRNYEFYLKDKDGGGGGASGGASGKITKFNVLITTYEMAITDRTHLSRIPWKYLVIDEAHRLKNKSCKLTIELRSYSFDHLLLLTGTPLQNNTQELWSLLNFLDPKQFSNLDQFLLEYGDLKESSQVESLQAILKPYLLRRMKERVEKSIAPKEETIVEVELTTVQKKYYRAIYEKNFSFLRKGGKSNQGPSLLNIMMELRKCCNHPYLTKGVEQSETSSIKDKDQIFQKLIQASGKLVLIDKLLPKLKLGNHKVLIFSQMVSVLDILDDYLTYRGYPHERIDGSIKGNDRQAAIDRFSKPDSDRFVFLLCTRAGGIGINLTAADTVIIFDSDWNPQNDLQAQARCHRIGQDKMVKVYRLVTKNTYERLMFDKASKKLGLDRAVLTKMNSLADSNNGNNSSSSSTTKDELPDKETINSLLKFGVYAIKDDDTSSEKFYEEDIDQILDRSLVVKQETVGDPLASSFSTASFCSSSATTQIDVNDPNFWDKFEPELNKKKDVILQPRQRKNVQRFGTFKDHEESSDDEEQSDFEPDEDDESTRDIGGINGTIGGQNSINKSWTAGERNKLKSAMLAYGSSRWDLIKTVAGLKRWSVEQVRQYGRAFLHKVLSNYNSDKEIPENNKFTMDMMNALVVELEPSIHSYHLEKKRLFDLELKQNEEEENNNNNDNDKVNSDSIEKESSSSSSSSPSSNINQDNSIEKKEENDTTVKDEKMVDIHELQETKVEPNVNANTNSTTTTTTTTTTTTTLLTEFNDNDNNDEGYHEYLNHITLNDSYFTEYLNRNTKKITRKLHNMALVSQILKLGYLSVAELLGDLSDAPFSWWKSDKDNDLLIGTYKHGFGEYEMIRNDPTLSFSKYKWKLSTDDDGGDDSKSKTESTTTTTIDEEEEDNEEEGVKKWPSAKVLSHRVKRLLRTMDFFKNKLEKESKNEKKKIEKEKKQEEKLKKRQEPKVEWTKREKDSFYRCITMYGIFEEESSLPTTTTTTTTTTTTLETTTTTATTIPTTKIELNWDLIKEKASLKKKSSELIELYYNELISKCESAVQEEKKFRSNVLFNTKENQMKLKQDKLQKGGLSSSTSSTDLQQQQQQSTGDDDDLLEDDEKGGNIDKKPSGSDELSLVQCKRVLSRIQFFQKLRNVVLKIKDLEEVFKNLPSPYHGFPSWWKTGTHDISLLQGVSKHGYSQYEDICNDQSLPFHELAQSLRLDKEKEKGSGGDSGVDDDASDKKRKRKENILDLINFPKDKSISKRLDFIVFYALNPPKPQSKHSAFDKILLPIDSGDNSNIQDNNNNNNNNNNNNKNNNNKNNDNENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNANNNNNNINDNNNTNNANNNNNNDNNAKNNNTFTYGKSTKSKNRPPSSPMKSNRNQNVNNNHKNINNTNGIVVEKKASLINILHSEEEFSDNEGFKRIDTTDDRLKKKQKSSPYKKHKQPTYQRPNLECGSDLETEYSDDDFGDSNTHDKYIHIPTNPKNKQSTQLSETLFSIKPTTSLFNHNKNFNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNSLFTKNNNNNNSNSVLNIKNINSSNNGNNISTEFDFSPRTNKNNYSNNNNNDINNNNNDNNNNNNNNLPRLPSISSLSDNGSFFGLPNKLGPIPKPYRDNRDTNNKSSFHFQNNEEFENQPNFSNKSFMGNSSISYQSNNNNNNTNSFNNFNNNNNNNNNSNNSNDNNYNKNNNGYNKNNNNRFEYKRNSQIQDDGDYEYEEDDGYINDDMIYIPRK
Protein: Uncharacterized protein (Q38FW3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- SET domain-containing protein
- NADH dehydrogenase 1 beta subcomplex subunit 7
- Flavoprotein monooxygenase, putative
- Sulfotransferase
- Uncharacterized protein
- FAD-binding domain-containing protein
- Complex 1 LYR protein domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Complex 1 LYR protein domain-containing protein
Sequence:
MYRRLCARSCIRQSLLMHVRLLRTSCVENVDPVGEDSLKDSSVREAVVISEVNIPNQIYEDKHGGIKLGDVHPVSEKENVFVEMNQLKYLFSQEGPYIGSKRKDATSDSVSDRGRRKVVRVPQPEVSYVPNETSFRRLPKNTRIPNEYELRALYPMSTGLALVEGQADCVDHSAFSPDEDPSPMVFSMIVPSGWSKTDQCPYMVVLPDHRGVARDFEDVCANFFERPVHRQLMTEQKWVVVAPVINIKHNFQIPVEAIVARFCDWIVENFNVEHGRVHLFGKGNGAYVALRTVMEHKDVAISVTAILGRSGTPFRPLDRPQDKIRNLNGVHSLVFVPGLLRKQDWYYKFKFMMDMGRVRPALRNVHFADVRDHQVYYAINPYEFWNYMNFFRQHNIKMVTESGYGLH