Protein: Unconventional myosin ID (MyoID) (Brush border myosin IA) (BBMIA) (Myosin 1D) (Myo1D) (Myosin-IA) (MIA) (MyoIA) (Q23978)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unconventional myosin that functions as actin-based motor protein with ATPase activity. Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer. Generates left-right asymmetry at the level of single cells, organs and the whole body via its interaction with the actin cytoskeleton, both in the embryo and the adult. Normal left-right asymmetry of the larval midgut and hindgut requires expression in the embryonic hindgut epithelium during a critical time period, 10 to 12.75 hours after egg laying. This period corresponds to a late stage of germband retraction, and precedes left-right asymmetric morphogenesis. Expression in segment H1 of the imaginal ring is required at 0 to 24 hours after pupation for changes of cell shape and orientation in the H2 segment, which then gives rise to normal, dextral looping of the adult hindgut. Required during a critical period, 126-132 hours after egg laying, for normal, dextral rotation of the adult male genitalia. Has a double role by promoting dextral rotation in the posterior compartment of segment A8 of the male genital disk, and in repressing sinistral looping in the anterior compartment.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16598258, ECO:0000269|PubMed:22491943, ECO:0000269|PubMed:7589814}. Cytoplasm, cell cortex {ECO:0000269|PubMed:16598258, ECO:0000269|PubMed:22491943, ECO:0000269|PubMed:25659376, ECO:0000269|PubMed:7589814}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16598258, ECO:0000269|PubMed:16598259, ECO:0000269|PubMed:7589814}. Cell membrane {ECO:0000269|PubMed:26073018, ECO:0000269|PubMed:30467170}; Peripheral membrane protein {ECO:0000269|PubMed:26073018, ECO:0000269|PubMed:30467170}; Cytoplasmic side. Cell junction {ECO:0000269|PubMed:26073018}. Cell junction, adherens junction {ECO:0000269|PubMed:16598259}. Cell projection {ECO:0000269|PubMed:16598258}. Note=Detected throughout the cytoplasm. Detected primarily in the basolateral cytoplasmic region of immature enterocytes. Detected also in the apical cytoplasmic region in midgut enterocytes and follicle cells (PubMed:7589814). Colocalizes with the actin cytoskeleton (PubMed:16598258, PubMed:16598259, PubMed:25659376, PubMed:7589814). Colocalizes with arm at adherens junctions (PubMed:16598259). Colocalizes with ds at cell junctions (PubMed:26073018). {ECO:0000269|PubMed:16598258, ECO:0000269|PubMed:16598259, ECO:0000269|PubMed:25659376, ECO:0000269|PubMed:26073018, ECO:0000269|PubMed:7589814}.
Interaction partners:
- Paramyosin, long form
Sequence:
MAMQREAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTEKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFEVPAAYCV