Protein: Mediator of RNA polymerase II transcription subunit 12 (CeTRAP230) (Mediator complex subunit 12) (Protein dumpy-22) (Q20497)
Organism: Caenorhabditis elegans
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Required for asymmetric division of T-cells and for hypodermal development.
Subcellular location: Nucleus {ECO:0000269|PubMed:10970880, ECO:0000269|PubMed:12441291, ECO:0000269|PubMed:15790964}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 13
- Cyclin-C
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 18
Sequence:
MLRKTNLRMGTADVYKQNKNQEEDMLTTERLKKGYQMPLTQYELQSLVFNASENKLIRLEKAQKRSQSMIASVIHKKGEFHMNYDRERKIPKEQLPCFAPHNWKRILSDRVKFFSALARGTPLQQLSQRIPGFRRKELLFLEFSDYNISYDRAIWCVKLLCILGFNSSSKTQKKTLLDVATLELSQACNKTTIWLVTQLYKSFRNPIKRREATKTWNYLTGFMKYMFDDGVLDKQEFLNDLTEVFNQLFLQKNFKNPSVLSTFMKYYVYFVEDLSSSLVLARRSSTLLCQALGFLFEMAQDKRKIDAYYDSANKTFIKKEFENEDGEIYEFEDYDDFIDMLDEIPDVPYFDETDKTPEAQAEELIKQHEKRKAGSLKKSERRRRRGLSKNRPKKMPQNPSNEASLDHDKVQIKQEPMDYDEYGGQQSDNSMDYDSFSHQYDPSYEPLPFKPLHTDIPKKLTDDEEFKYMKIGKRSVTPERISGRYGSMTYPFWIQQGGVGIDPPKDEVLDFSNPTPTETVNTQPQIDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKEKSVDEHTNDLDVPINPDDAEMADANDKTDASEKQKLVEEEPTGKENEDDTSSKTAKTSTSAEKSEAPSIVDSNDKIDKEPNASSTSNDETSKDDTVPMESDPPAATEKPKESTEITTEEPLEVDKAPEVDKSEKEHEDDIMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDVADNEPEKIYTDEELAEIKIRKEKEMKIATLASHIKEKMVSDKKWKEKTSHAGWRTLDQCSQFSEALHLLSSMVQYMACVTPESFVWNDLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVMEGVEEVVDCLRLRHCEIVRRSQAAEDRWLPNAAFLQSFGRIIDTCVDVIGIMDNIDVEKPNAITNAGLRLFAFREKFEKQEALLKTMLMFKWCITEEREGSFRATYIAKLLRFGMDQNPENTIGGWQVMDLFFKFMSTEGPKHGSKMYQAHFDSTVAIMIEMMREKIFSITDILRELEKDSDLDYNAPLMERQRKQKIPKISKRHRKPETPDDTKLVHFTTEYTPKRLFMGKKMDLLERMIIILPQLDVDEDTDEYRLRRLLLFGLKPAANVYFRRARAIYKSITKEFTTRLYIEFDRSSKVTTAHKKINQNRLDDLLRQFRAQTYHDQHLILERIVYNFIDGIGGFLKKNCDDVPAPEVANIICEMYEFSMDITSIFDFFEMVNPYLKAVDDKIAHFRMDVLPDMYYTETAFIFVSFFMKHWQRFLLHPRACAIVNQCFVLIQDMIRADDHMITCWGRTVAIFVFHARKAIANAGLQNEEFLAEDSHFWRVFPNAQHVDLDVGYFNEDFAGVKLQLRGGTLRYDSYNDFKWLVSNMKPNLKKKPHLKRPNTRYSFVVRAFMEARQHGRNFDRINELANYCANITANDPPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFITCLAGKSAFYIPRLLAELTKHVFPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLSEAEPGVCLCLLIICGLCCVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTLGHISQLLEALQSRCRDANLVLPKNFPIKNPPKHQQELHREKAPYRPQYLFNIAKTVQFVICEQDWVTLRMFRFFQTRKMEAFNQDKLKQNCLGQQILRMALRRRTERENVHKLFEAHKISKKATVDKVLSFMNLWNFRATLFDLMLMIKEISPDGNSRHAQQGAIAADALMSEIGKCCRDMFLSAYKTKIKMPIAKTLTDFRLSDINKFWLIAPLVRMCPKPINIPPQYANTTVGTVAAKFLREAALLMDTPPTTPKERLLQCSWAMSKVPFINMILTCLQCEKMQQSKDVFLQSLYTQLQRETLRDHHRRSNWTNRREHRDCTIFRITLIGYIYKEILKATHVETWGLLIFQLMFHGIINPVREKLIYETCFDMLHHMVLWTLVDGDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLHRFLPIGKMQMSTISYKKYQKRPKVNQKMSKKFLAGEGLKNGKYSFLPEEKAKTNAFEHTDHLGDLIVKGGWKFRMFQTTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLAPPDIEITKIIEQPVPVIDEEEAKKRAEEEKEAAEKKEESKNAEDEKNKNNAENKKDTKEGEKGKSKDKEKDGEKEKCKDASKKDDVTSEKNELEKRASDAAAATNAPETNKDMDTSTPKPAPVTRSPATRGRGGGRKRNSGARGGGPRAKRANSRADTAQAAAATTQWNAPIANTSNPAAGGNFHAAMRGNQPPMSNGSSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAMGNTSSMPPSGPPMPMGSSMQSAGATQQLQGMQKHQMGGSMSGMNQNMGGMNQSMSHQAPPPYSSTNEMNRPLMNQYGGPHFAAPNPGPLNRSSGPVSSETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMKEQQLLERKRAIEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEAEERMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEARMREAREAELSRQRMEQQRRSQQNPYMNQQGQYSQQPPPSYQQSSYPNNYQPGQQGNQPPNYQQPSHQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQSFSGPGGINQPSQPGYSGYNQQGGQGQQGQMQQQRNPFGNQQDMQQPGAAKLMHAKPNEAHAQQYQHTQNQLSLAQKEKEKQYFQAKNLQASQANAQQQQQRFGDVVAGNVAGYGRPYGQQQLGASDQMGTSQLPGASTSRMNQGSSNPQGGMQSYQQQQPVLGQPGPIQTGQSTQQQIPAQSQQQYNSGRPQMHTTPTKNDMSARAPSGAMGQIANRMGHGTNPQGYGSTGQNVPGGYQQGQQQSGQGSYPQAQQQQPNQYSGSNQQVGQQAQQQQQQPLNQNVSQSQSAAQFGRPSQDSAYQQSGYNQTGNQSYQRPDQQQQGAQQNQWSGSNQAQNQLRSQQQAQQPLQQPQQSQQFQQPAQQAKNPMAQSAQYGGFGGQQQGYDQQQQGQIAPQQAQNPQASQSYGQQQTQQNRYGMGSSGYTANSGGSSNILNQSMEESGLNQGFSGASSNASSQQGGSSQMQQSGYGMPGNQMQMQQNQKQQVQRGMPTGMGQTNMGQSGMGQSGMGQTGMSRSGLGGGIGQQGQQSQQPQQPQVSQQQNQRGMNPGAQLPPYSTGQQQHQPQQSQISQQQQQQDQYRRMQAAQMQQQPTAQGQQNRMGMPSQQQSGAAYSNQMQFQGVRQGQQGMGGMGGSGQQQPQTQPHGSNQYYQQQQDQRMQQQPQQPGQQQQHGYGMGQYPNQQPPNQY