wanglab/gogpt-training-data huggingface dataset:
Protein: G9a, isoform B (EC 2.1.1.355, EC 2.1.1.356, EC 2.1.1.367, EC 2.1.1.368, EC 2.1.1.369, EC 2.1.1.371) (M9PGH7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
- Heterochromatin protein 1
- Histone deacetylase HDAC1
- Histone H3
- CoRest, isoform G
- Histone H3.3A
- Calmodulin-lysine N-methyltransferase
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase
- Possible lysine-specific histone demethylase 1
- Polycomb group protein Pc
- Protein snail
Sequence:
MTDFVELMNSMSSTFNSDCATSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTALSPEENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCKYASQSSSTNASPTNATTAPENETGTLSSTNTEKIGHA
Protein: UPF0301 protein Rv0038 (P9WFK5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Vitamin B12-dependent ribonucleoside-diphosphate reductase
- Ribonucleoside-diphosphate reductase subunit alpha
- Probable transcriptional regulatory protein
- Uncharacterized protein Rv1359
- Uncharacterized protein Rv1488
- Putative mycofactocin biosynthesis transcriptional regulator MftR
- site-specific DNA-methyltransferase
- Possible transcriptional regulatory protein
- Possible transcriptional regulatory protein NadR
- Manganese transport regulator
Sequence:
MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIVEHNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGADPEGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWIVLSALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (Q90ZK8)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVWANGMSICARFLMWLLLLFMFIRKVVPEDNVITTEKGRVRGTNLQVLGGTVTAFLGIPYGKPPIGRLRFQKPEPFEKWSGIWKATKHANSCYQLIDTTYPGFPGTEMWNPKTNLSEDCLYLNVWIPSPKPKNATVMVWIYGGSFETGSTSLPVYDGKFLARVERVIVVSMNYRTGALGFLALPGNKEVPGNAGLFDQRLALQWVQENIASFGGNPKSVTIFGESAGSASVSYHILSPKSHPLFTRAIMQSGSANAPWAAITASEARRRTVALAKQLKCPTSDETELILCLQDKDPKDILENEVYVVKYFSLLHIYFCPTVDGDFLADMPEALIKNGIFKQTQVLVGVNKDEGTSFLVYGVPGFSKDSDSLINKTQFEVALTLSFPQVSKLAIESIIFQYTDWENEQKPEHYRDAMDDVIGDYHIICPAVEFAKTIAEVGNNVFFYFFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTKAEEILSRSMLRYWASFAKTGNPNGTLINGTRWPVFTSTEQKYLTLNTDASEILTKLRAQQCRFWNMFFPKVLEMTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKERCAGSN
Protein: G-protein coupled receptor 146 (G-protein coupled receptor PGR8) (Q96CH1)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000305|PubMed:38503280}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA
Protein: RE28849p (RE52979p) (Q8SYM6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAPGENYATLMLRISIDVELTDKSTKLVCFMLKVPHNVPQMEQMLAMANFFNSENKVYSDILPKLEELYKAKGLDITFAPKAFKLDSVKEPKLANTVLMSDLSQDGFKNLNRLECLNLEQTKFALKKLAQFHAASSMNVQVNGPYEDQFVNGVMGGNKEVLMAFYEGMVASFRTALMANLKNFKNGEEFREKLEKAFVQIFLDFEHLMTADPDEFNVLNHGDCWMNNLLFKLDSKGEVQDMLFVDFQNPKYGSPTQDLFYLILTSVHIDYKLDYFEYFIRHYHEQLTQHLGLLGFTGKQPSLRELHMLMYKHGSWAVFPSIGVLPIVLLDPNESATFENFLGDSESSAKFKNLLYTNKRYHGYIEKLLPWLDNKGFLEAYFINQVVAPETPSSEQPENPKNQILDWLNVSDFAEVISSAEPEFDKIVGGSWSSATKPGDNFASKLLKIDIETQLKDHTSKTFSYILKVQPKSTPDNFTDVNMFPKEMEMYQKYVPAFEQLYKDAGLTVTFTANSFVLNKAVKEEYLLMENLQTKGFKMADRMKGLNMEHTKSSLKKLAQWHAASIKYKELNGAYPPLYNDGIYIEQTRDVFHNMFASAKEAYIRIFGTFEGADEYLPKLEWIIDNHVDQVLEDAKINEQAFNVLNHGDAWINNIMFQYDAEGRLKETYLLDHQNAKYGNPAQDLYYFLISSAELDIKVDEFDNLIRFYHENLVEHTKLLKYNGFVPSLSELHAILIEHPAFAVGTVISTLTVCLTDEGFNPELFFVETPESEAFRTKLLGNERYKAHVEKIMPWLNRRGLLDP
Protein: Agamous-like MADS-box protein AGL12 (Protein XAANTAL 1) (Q38841)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription activator that regulates root development by controlling cell proliferation in root meristem. May mediate responses to auxin in the root. May act as promoter of the flowering transition through up-regulation of SOC, FT and LFY.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Agamous-like MADS-box protein AGL16
- AGAMOUS-like-56
- MADS-box protein
- At5g26880
- Transcription factor bHLH52
Sequence:
MARGKIQLKRIENPVHRQVTFCKRRTGLLKKAKELSVLCDAEIGVVIFSPQGKLFELATKGTMEGMIDKYMKCTGGGRGSSSATFTAQEQLQPPNLDPKDEINVLKQEIEMLQKGISYMFGGGDGAMNLEELLLLEKHLEYWISQIRSAKMDVMLQEIQSLRNKEGVLKNTNKYLLEKIEENNNSILDANFAVMETNYSYPLTMPSEIFQF
Protein: Toxin zeta (UDP-N-acetylglucosamine kinase) (UNAG kinase) (EC 2.7.1.176) (Q54944)
Organism: Streptococcus pyogenes
Function: Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first committed step in cell wall synthesis, which is then blocked. Phosphorylation is inhibited by cognate epsilon antitoxin. Part of a postsegregational killing (PSK) system involved in the killing of plasmid-free cells. The zeta toxin induces programmed cell death.
Interaction partners:
Sequence:
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYETMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQPTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
Protein: 4-coumarate--CoA ligase 4 (4CL 4) (EC 6.2.1.12) ((E)-ferulate--CoA ligase) (EC 6.2.1.34) (4-coumarate--CoA ligase isoform 5) (At4CL5) (4-coumaroyl-CoA synthase 4) (Sinapate--CoA ligase) (EC 6.2.1.-) (Q9LU36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioesters (By similarity).
Interaction partners:
- Cinnamoyl-CoA reductase 2
- Trans-cinnamate 4-monooxygenase
- Cinnamoyl-CoA reductase 1
- Cytochrome P450 84A1
- Flavone 3'-O-methyltransferase 1
- F5F19.5 protein
- Phenylalanine ammonia-lyase 1
- Chalcone synthase
- Phenylalanine ammonia-lyase 4
- Phenylalanine ammonia-lyase 2
Sequence:
MVLQQQTHFLTKKIDQEDEEEEPSHDFIFRSKLPDIFIPNHLPLTDYVFQRFSGDGDGDSSTTCIIDGATGRILTYADVQTNMRRIAAGIHRLGIRHGDVVMLLLPNSPEFALSFLAVAYLGAVSTTANPFYTQPEIAKQAKASAAKMIITKKCLVDKLTNLKNDGVLIVCLDDDGDNGVVSSSDDGCVSFTELTQADETELLKPKISPEDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNLNFTANDVILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLAFIKSPETERYDLSSVRIMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKNPFKTKSGACGTVIRNAEMKVVDTETGISLPRNKSGEICVRGHQLMKGYLNDPEATARTIDKDGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPSIDDAAVVAMKDEVADEVPVAFVARSQGSQLTEDDVKSYVNKQVVHYKRIKMVFFIEVIPKAVSGKILRKDLRAKLETMCSK
Protein: Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase) (Q9BVM4)
Organism: Homo sapiens (Human)
Function: Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.
Interaction partners:
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Fibrinogen alpha chain
Sequence:
MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSGRLVEGEVYAVDERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR
Protein: Galactosyltransferase family protein (F4JIK9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MATSRLARFVSEVAPPQFVTVMRRHRAAKQKLDTIKEEENKEDSFNGGMVVMMKTSHQHTLLIFRSCRDLAAIVGFRILLFTGFSGFYLVFLAFKFPHFIEMVAMLSGDTGLDGALSDTSLDVSLSGSLRNDMLNRKLEDEDHQSGPSTTQKVSPEEKINGSKQIQPLLFRYGRISGEVMRRRNRTIHMSPFERMADEAWILGSKAWEDVDKFEVDKINESASIFEGKVESCPSQISMNGDDLNKANRIMLLPCGLAAGSSITILGTPQYAHKESVPQRSRLTRSYGMVLVSQFMVELQGLKTGDGEYPPKILHLNPRIKGDWNHRPVIEHNTCYRMQWGVAQRCDGTPSKKDADVLVDGFRRCEKWTQNDIIDMVDSKESKTTSWFKRFIGREQKPEVTWSFPFAEGKVFVLTLRAGIDGFHINVGGRHVSSFPYRPGFTIEDATGLAVTGDVDIHSIHATSLSTSHPSFSPQKAIEFSSEWKAPPLPGTPFRLFMGVLSATNHFSERMAVRKTWMQHPSIKSSDVVARFFVALNPRKEVNAMLKKEAEYFGDIVILPFMDRYELVVLKTIAICEFGVQNVTAPYIMKCDDDTFIRVESILKQIDGVSPEKSLYMGNLNLRHRPLRTGKWTVTWEEWPEAVYPPYANGPGYIISSNIAKYIVSQNSRHKLRLFKMEDVSMGLWVEQFNASMQPVEYSHSWKFCQYGCTLNYYTAHYQSPSQMMCLWDNLLKGRPQCCNFR
Protein: SD15892p (Q8MRX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMNKLAKEVVPPAPGMVTKLKERMLLRQASTPPTASSWRRSNGWKRVTSPVHPPVAVSPKKKAAKSTEPPKSCLPKAQPTRIPTSIHSSVSSSSSMSSSCSPSPSSPSPQSPQQRSPGQQTQQQQQQQQQRKSKIPPPVPVRRSYAS
Protein: DNA-directed RNA polymerase subunit Rpo13 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit F) (Q4JAJ6)
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Ref.2). In vitro binds dsDNA but not ssDNA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B8YB65}.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase subunit Rpo1N
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo8
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase subunit Rpo4
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo10
- DNA-directed RNA polymerase subunit Rpo2
- DNA-directed RNA polymerase subunit Rpo7
Sequence:
MSEDDSKKEPEPEETEAEIKHEEISREEDDEGGEFSTVTISDIEMLLKDTEIWDKLLRNELSIEEAKKMFDDVARSYSKADKKKRRVEKKPKKGKVTKKSDEEEE
Protein: U-box domain-containing protein 4 (EC 2.3.2.27) (Plant U-box protein 4) (OsPUB4) (RING-type E3 ubiquitin transferase PUB4) (Q6EUK7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Possesses E3 ubiquitin-protein ligase in vitro.
Interaction partners:
- Chitin elicitor receptor kinase 1
Sequence:
MAAAASASSPVEFLLRRPAPRRRRLPLAGAFFAPTGLAGATLLRAVASLAASLVAGARPPSQRRNVDALARRLALLSAILESILLDTAAAGAFSDAANLCFRELYVVLFRAELLVSYVASAGRAWALLRSPHLAASFRDLDAELAVVLDVLPAASLRLSHDATGLLDLLRAHCRCRAPAQYHDPDEAALRERLMDALRQFDLGQPPDHPSLQSLLADMGISTAASCRAEIDYLEEQILSQEEDTDLPLVGSVLALLRYCLFAVFDPSNAKALRDWPLSGNRQRLLSIGGGDDTSFSVPKEFSCPISLDLMRDPVVASTGQTYDRPSIIQWIEEGHSTCPNSGQTLADHRLVPNRALRSLISQWCGVYGLQYDSPESNEGMAECVAASCSSRAAMEANKATARILVRMLEDGSENVKAVAAKEIRLLAKTGKQNRAFIADLGAIPLLCRLLLSNDWMAQENAVTALLNLSIFEPNKGRIMEQEGCLRLIVGVLQNGWTTEAKENAAATLFSLSVVHNFKKLIMNEPGAVEELASMLTKGTSRGKKDAVMALFNLSTHPESSARMLESCAVVALIQSLRNDTVSEEAAGALALLMKQPSIVHLVGSSETVITSLVGLMRRGTPKGKENAVSALYEICRRGGSALVQRVAKIPGLNTVIQTITLNGTKRAKKKASLIVKMCQRSQMPSAMALGSTLTVVDRSLVGNNTLRRAASFGSGELSNPISISVQVP
Protein: Kinesin-like calmodulin-binding protein (ZWICHEL) (F4JXM5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEGQRGSNSSLSSGNGTEVATDVSSCFYVPNPSGTDFDAESSSLPPLLSLCHSSPAPQVALSIPAELAAAIPLIDRFQVEAFLRLMQKQIQSAGKRGFFYSKKSSGSNVRERFTFEDMLCFQKDPIPTSLLKINSDLVSRATKLFHLILKYMGVDSSDRSTPPSLDERIDLVGKLFKKTLKRVELRDELFAQISKQTRHNPDRQYLIKAWELMYLCASSMPPSKDIGGYLSEYIHNVAHDATIEPDAQVLAVNTLKALKRSIKAGPRHTTPGREEIEALLTGRKLTTIVFFLDETFEEISYDMATTVSDAVEELAGTIKLSAFSSFSLFECRKVVSSSKSSDPGNEEYIGLDDNKYIGDLLAEFKAIKDRNKGEILHCKLVFKKKLFRESDEAVTDLMFVQLSYVQLQHDYLLGNYPVGRDDAAQLCALQILVGIGFVNSPESCIDWTSLLERFLPRQIAITRAKREWELDILARYRSMENVTKDDARQQFLRILKALPYGNSVFFSVRKIDDPIGLLPGRIILGINKRGVHFFRPVPKEYLHSAELRDIMQFGSSNTAVFFKMRVAGVLHIFQFETKQGEEICVALQTHINDVMLRRYSKARSAANSLVNGDISCSSKPQNFEVYEKRLQDLSKAYEESQKKIEKLMDEQQEKNQQEVTLREELEAIHNGLELERRKLLEVTLDRDKLRSLCDEKGTTIQSLMSELRGMEARLAKSGNTKSSKETKSELAEMNNQILYKIQKELEVRNKELHVAVDNSKRLLSENKILEQNLNIEKKKKEEVEIHQKRYEQEKKVLKLRVSELENKLEVLAQDLDSAESTIESKNSDMLLLQNNLKELEELREMKEDIDRKNEQTAAILKMQGAQLAELEILYKEEQVLRKRYYNTIEDMKGKIRVYCRIRPLNEKESSEREKQMLTTVDEFTVEHPWKDDKRKQHIYDRVFDMRASQDDIFEDTKYLVQSAVDGYNVCIFAYGQTGSGKTFTIYGHESNPGLTPRATKELFNILKRDSKRFSFSLKAYMVELYQDTLVDLLLPKSARRLKLEIKKDSKGMVFVENVTTIPISTLEELRMILERGSERRHVSGTNMNEESSRSHLILSVVIESIDLQTQSAARGKLSFVDLAGSERVKKSGSAGCQLKEAQSINKSLSALGDVIGALSSGNQHIPYRNHKLTMLMSDSLGGNAKTLMFVNVSPAESNLDETYNSLLYASRVRTIVNDPSKHISSKEMVRLKKLVAYWKEQAGKKGEEEDLVDIEEDRTRKDEADS
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (D3ZCD0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Angiopoietin-1
- Angiopoietin-2
- Angiopoietin 4
- Fibroblast growth factor 2
- Vascular endothelial growth factor C
- Platelet-derived growth factor subunit B
- Hepatocyte growth factor
- Placenta growth factor
- Kit ligand
- Vascular endothelial growth factor B
Sequence:
MDSLAGLVLCGVSLLLYGLVEGAMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCNRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGSEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPYGHYGPDCKLRCHCTNEEMCDRFQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTVLQPNDFNHTDHFSVAIFTVNRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPRTDYELCVQLVRPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVPGNLTSVLLNNLLPREQYSVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Protein: At1g68330 (Membrane-associated kinase regulator) (Q8RWC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAIDVCCSEASGSGISPRISFSYDLDSTDDGEVRLDSTLLDSGSEFDFCFGSSCSVQEVSPADELFSEGKILPVQIKKEESLPQTVTFRVPRSASLSSSSSSSSSSSSSSRAPEKKMRLKELLLNPESDFEDKPRGLFLQFKRSISLNYDKSRNSKGLIRSFHFLSRSNSTPNPNLDLLPKETHHPHKTHNLPKHKPPLRRSSSLSSSSVPFYSKKPLGRNSFGNGNGGVRVSPVLNFPPPAFISNVADGFFSIGSLCNGKTNTKTKL
Protein: CD4-1 molecule precursor (CD4-4 protein) (B5KH12)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLGLILIPLFITVLKAQESHEVIYAQVGGTVTLPREKIERKYSNIKTQDIYVNWFLESTLTINRNPQSSSSKGTNARVSLSADFSLQISPVEESDFVIWRCEQHVLARNYKKTYKLHKVSIPKVPALLVGGRLFLKYVKDVSSVNPSVTWISPKNEGCQEHKNAKDTVLVPSVSTCHNGVWTCQLKYENKKTEATTTVSVIDLAPSPADPIYTSISQSSTVSIPCALSSAIPWSVLNETLQGGSWSFTPLSEPRSPLSLLTLNVGSVVRWDLANGANFTDGKRVITNHNLSIQNLPVKETIRGVYKCSLKFNTKTISREVKVEVLKVSPSGSLKVFEGTRLNVTCSLGHMNTAGLEVKWTCASNCPPFNHKSPPHLSVLSFPKIRMQDKGLVKCELWKNSQKLTSAQLYLRVEKAPVDIWLCVAIGSGVVVFILLVAFAIIYIRRHKQMMMYRRRKTRFCCCNNNKQPKGFYKT
Protein: Auxin-responsive protein SAUR77 (Protein SMALL AUXIN UP RNA 77) (Q9LQI6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the regulation of ethylene receptor signaling. Promotes cell expansion and plant growth.
Interaction partners:
- F14J9.2 protein
- Plant self-incompatibility protein S1 family
- Putative purine permease 19
- Pentatricopeptide repeat-containing protein At5g12100
- Small polypeptide DEVIL 19
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Regulator of Vps4 activity in the MVB pathway protein
- Jacalin-related lectin 5
- Plant self-incompatibility protein S1 family
- Transcription factor bHLH94
Sequence:
MAIFGKLTKLKSAIKKWPSLTKNHHSTMCTASTAVSEVSKCEDLHVVYVGKSRRPYMLSSHVIAHPLFQELLDRSSRFIEERHDQETVLVACEVVLFEHLLWMLKNSSSDHGDEDDRERGSVEELAEFYTY
Protein: Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF) (O35485)
Organism: Rattus norvegicus (Rat)
Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity).
Subcellular location: Secreted {ECO:0000250}. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. {ECO:0000250}.
Interaction partners:
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Neuropilin-1
- Angiopoietin-1 receptor
- Platelet-derived growth factor receptor beta
- Platelet-derived growth factor receptor alpha
Sequence:
MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYARATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQILMIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDRVAIPHHRPQPRSVLSWDSAPGASSPADIIHPTPAPGPSAHAAPSAVSALIPGPAVAAADAAASSIAKGGA
Protein: Spn43Ac (Q6V6U3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
RFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESVIKYKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMDQPVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAVRTXASVLL
Protein: E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50) (Q86XT4)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:24308962, ECO:0000269|PubMed:29604308}. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins. {ECO:0000269|PubMed:22792322}.
Interaction partners:
- Protein deacetylase HDAC6
- Transducin beta-like protein 2
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- 28S rRNA
- Gamma-butyrobetaine dioxygenase
- Peptidyl-prolyl cis-trans isomerase FKBP10
- General transcription factor II-I repeat domain-containing protein 1
- B-cell CLL/lymphoma 7 protein family member B
- Zinc finger protein SNAI1
Sequence:
MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL
Protein: Protein teashirt (P22265)
Organism: Drosophila melanogaster (Fruit fly)
Function: Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk. Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity. Necessary, in combination with Scr, for the formation of the prothoracic segment. Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes. Required for proper development of proximal leg segments. Has differential functions along the dorso-ventral axs of the antennal and leg disks. May play a role in wing hinge development. Possible involvement in chromatin structure for modulation of transcription. Binds DNA and can act as both a transcriptional repressor and activator. Positively regulates its own expression as well as that of Dll. Negatively regulates the expression of mod. Required for Wg-mediated transcriptional repression of Ubx in the midgut. Also represses transcription of lab in the midgut and is necessary for the proper formation of anterior and central midgut structures. Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg.
Subcellular location: Nucleus. Cytoplasm. Note=Initially localized in the cytoplasm soon after the blastoderm stage, and becomes nuclear by stage 9.
Interaction partners:
- Homeobox protein homothorax
- Transcriptional coactivator yorkie
- Homeotic protein antennapedia
- Homeobox protein extradenticle
- Homeobox protein abdominal-A
- Protein sine oculis
- Protein wingless
- Protein phosphatase eya
- Brinker
- Protein distal antenna-related
Sequence:
MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSEHGGGAGSGGVGHRLDAAALSTGVMPGEGPTTLHSSFPAVPQSLPSQPPSMEAYLHMVAAAAQQYGFPLAAAAAAGAGPRLPLPLANEAAAPFKLPPQASPTASSNNSEALDFRTNLYGRAESAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAAANIFRAGQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQPTPNQNSESGGGSGGGAAGSGAVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSGNANANSDAKESHNSLSSEESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPKKREKSLPVRKLLEMKGGSGTTQEDHSNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGGSAKAAGASSVLSAIEQMFTTSFDTPPRHASLPASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKQQQGGGHDEESSKPAIKQEREAESKPVKMEIKSEFVDEPNEAEETSKMEAAVVNGSATNNNNNIVERSSPKTPSSAASPQTRLLPPRSPAESQRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDSLGSSGAGANSRAKLAAAAAAGGSESPENLTAGGNSLAALRQFCVKKEKTA