wanglab/gogpt-training-data huggingface dataset:
Protein: Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) (Q8TBJ4)
Organism: Homo sapiens (Human)
Function: May play a role in neurite outgrowth and neurogenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6WAY2}; Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6WAY2}.
Interaction partners:
Sequence:
MAVGNNTQRSYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVHIQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAQEKTILTGECCYLNPLLRRIIRFTGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTKSSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEVT
Protein: Transketolase, chloroplastic (TK) (EC 2.2.1.1) (O20250)
Organism: Spinacia oleracea (Spinach)
Function: Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:9523694}.
Interaction partners:
Sequence:
MAASSSLSTLSHHQTLLSHPKTHLPTTPASSLLVPTTSSKVNGVLLKSTSSSRRLRVGSASAVVRAAAVEALESTDIDQLVEKSVNTIRFLAIDAVEKANSGHPGLPMGCAPMGHILYDEIMRYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVLEEDLKTFRQWGSRIPGHPENFETPGVEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEIVDHYTYVILGDGCQMEGIAQEACSLAGHWGLGKLIAFYDDNHISIDGDTAIAFTESVDLRFEALGWHVIWVKNGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGFGSPNKSNSYSVHGSALGSKEVEATRQNLGWPYEPFHVPEEVKKHWSRHTPEGASLEAEWNTKFAEYEKKYPEDATEFKSITTGEFPAGWEKALPTYTPETPGDATRNLSQQCLNALAKVIPGLLGGSADLASSNMTLLKMFGDFRRTHRKKETFRFGVREHGMGAICNGICLHSPGFVPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEALSKFPAMPNILMLRPADGNETAGSYKVAVENRKTPSILALSRKKLPNLPGTSIEGVEKGGYTITDNSSGNKPDVILIGTGSELEIAAKAGDELRKEGKAVRVVSFVSWELFEKQSDEYKESVLPSDVTARVSIEAGSTFGWHKIVGSKGKAIGIDKFGASAPAGKIYQEYGITVEAVVEAAKSVC
Protein: Meiosis regulator and mRNA stability factor 1, isoform D (Meiosis regulator and mRNA stability factor 1, isoform F) (RE61489p) (SD03440p) (Q7KWG9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFQRHTSVIDLHRWNYPECWPFDRNGKVENIYVMEHSDPVPYQQLSTLSPTTALYSNFNNSLEAGTAERLRLNKTGSQVHSLYVGDGQVQNASEPLSFPSHLNLYQYVRTPANFTINSRNRYIPYYNNRSYSASTTGFPIASTPLISSHAHIQDQQGAASYQTIVPLYQTASHCAQQHTTLASVAPIVDNSFVESTTCPMAGITSHNIKMKMIPPNVLLPCSRPTTTAVTIQRSTGEDGGDKEGHTFAKITEMSDAVTLQITNLDYSLDESHIRSFLLNQLKPITPVVSLVFEGSSYAKVTVPDLYFAKQVVSNLHRKKIGHKRMLVSYTRDSSLTEVNTLRCQVAGLLKDVPFNTLPMYKFRELFQSRFKTSISVLDLYKMQDICTINSDNNEEKFISLNPELVNTLDISPLMEGLQHSVPYCSIHFKKEQHKGWAEQEIEPLPNVFMSISEIQKLIYPLLKVHTGDIPVATLLHCVKEELNVSIMANENGVNLEHLICCVQGIQVRANNFGIKILGWLEINKEMQSGTFNASSNTCSLTASDRTNCGSYFKNSVADPLFQISREVIELLKMSPKSTMKFNRFIPAYHNHFGKQCRVADYGYTKLIELFEALSNVVQIMGDGENRQITLSHRIQIRRFTSDLLRVLRANGNNSVLLSQLPLVFTQTQNKTFDITDYGVCDLIDILDGLVSSNIVTLGAAQNGKDILISMPKRKQTNSELEKTCVFAGEMVELFQNALQYTILFQKFVRSYHYHFAYQCRLSDYGFLKLADLLDAINGLVEMKLTSDEDKKIVLSPQVARRVFAEQCENLIRNATGNSSHCMKLEQVLVLHKKKYGYQIQPKTLGVMDMATAVELLPYVELKKKEQAIWLICHNNDHEFRFLCYRVCKYVMERDPSASVWTNVRGEVKLTKSQQFVKPIEKSILVRDFNAKYKDHLSESALLAMRQAIEVYDDGGIQCIRLTRFMKFIIAIVRMLEQRPSMYLYEIKNGLNCGLSTTFEFGFPNLYSVVAAHKDLFSINNGPTQERSEVSINMNCELRQSSLSKDQCVLESQKLTNSKHRAQRSFHSHIGEHNGLPISQPPLKRSATINNCSTFQTYHADTDIFNVPANCLPPRTNLSLPNSFGSSLESGSFSNSYSNKENSMKSLHLFNSSFNSSGELNASLGAGDLTNISLGTGIAVDTSNEPSELWRRRQQNFNRPNSSNFRKSDNGTDGTYTIGNYIAPPIGSIYEPLKYNGQDKEKLPFWIDPIWSKGSEQLRHDILNIRLPKARTTKTFSNILSPYTISKNENLKRQLFSFDNHDRKIA
Protein: FI23915p1 (GluRIID) (Glutamate receptor IID) (Ionotropic glutamate receptor subunit IA) (Q9TVI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}.
Interaction partners:
- FI04462p
- Glutamate receptor IIC
- Glutamate receptor IIB
- Glutamate [NMDA] receptor subunit 1
- Glutamate receptor IIA
- Peripheral plasma membrane protein CASK
- Neuropilin and tolloid-like, isoform B
- Glutamate receptor 1
- Glutamate receptor IB, isoform B
- NMDA receptor 2, isoform C
Sequence:
MHFCWISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLKTDSEENMPVED
Protein: Bruno 3, isoform I (M9MRZ5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHIIELVGQPKVEFAQQVTLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAFVKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSPYGAYAQLPSPPELQQQQQAALMAAAATAPGSAAAYMNPMAALATQIPHGLNGTGQPPSLPSPTMPNFNMGANTPNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLHLTIPPQGLPNGDAATLQHAFPGLPPFPGVDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY
Protein: Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein) (Q9D5J6)
Organism: Mus musculus (Mouse)
Function: Acts as a modulator of macrophage activation through control of glucose metabolism.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22682222}.
Interaction partners:
- Potassium voltage-gated channel subfamily A member 3
- Potassium voltage-gated channel subfamily A member 1
- Cystinosin
Sequence:
MASRPVTLGIDLGTTSVKAALLEAAPSLPSGFVVLASCARAARAETESAVAGPQGREQDVTRIIQALNECLDALPRQQLQRVRGIGVSGQMHGILFWKAGQGCEWMEGGPAFVFEPRAVSHLVTWQDGRCNSSFLASLPKPDSHLSVATGFGCATIFWLLKNSPEFLKSYDAAGTIQDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNLDTLEKAGFPIHLLPDIAEPGSMAGRTSHTWFEIPKGTQVGIALGDLQASVYSCMGQRTDAVLNISTSVQLAASMPVGFQPLQTPDPAAPVAFFPYFDRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAAQQKDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPFQQLKEWGVARVVGSGSALSRNEVLKQEVQRAFPFPVCFGQDVDAAFGAALVMLQRDLSQKEP
Protein: Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] (P33587)
Organism: Mus musculus (Mouse)
Function: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P04070}. Golgi apparatus {ECO:0000250|UniProtKB:P04070}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P04070}.
Interaction partners:
- Endothelial protein C receptor
- Thrombomodulin
- Prothrombin
- Alpha-2-antiplasmin
- Coagulation factor VIII
- Plasminogen activator inhibitor 1
- Regulator of G-protein signaling 19
- Antithrombin-III
- Proteinase-activated receptor 1
- Alpha-1-antitrypsin 1-4
Sequence:
MWQFRVFLLLMSTWGISSIPAHPDPVFSSSEHAHQVLRVRRANSFLEEMRPGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSAPPLDHQCDSPCCGHGTCIDGIGSFSCSCDKGWEGKFCQQELRFQDCRVNNGGCLHYCLEESNGRRCACAPGYELADDHMRCKSTVNFPCGKLGRWIEKKRKILKRDTDLEDELEPDPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCVEGTKKLTVRLGEYDLRRRDHWELDLDIKEILVHPNYTRSSSDNDIALLRLAQPATLSKTIVPICLPNNGLAQELTQAGQETVVTGWGYQSDRIKDGRRNRTFILTFIRIPLVARNECVEVMKNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHTNNYGIYTKVGSYLKWIHSYIGEKGVSLKSQKL
Protein: Flavone 3'-O-methyltransferase OMT2 (EC 2.1.1.42) (Q42653)
Organism: Chrysosplenium americanum (American golden saxifrage)
Function: Catalyzes the 3'-O-methylation of the flavonoids luteolin and quercetin. Catalyzes the 3- of 5-O-methylation of the phenylpropanoids caffeate and 5-hydroxyferulate. Substrate preference is 5-hydroxyferulate > luteolin > quercetin > caffeate. Apigenin, kempferol and 3,4-dimethylquercetin do not seem to be substrates for methylation.
Interaction partners:
Sequence:
MLFAMQLACASVLPMVLKSAIELDLLEIIRGQDTCMSPTEIASHLPTTNPDAPAMVDRILRLLSCYSVVTCSVRSVDDQRVYGLAPVCKYLTKNQDGVSIAALCLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMSSFEYHGTDPRFNKVFNRGMSDHSTITMKKVFQTYQGFQGLTSLVDVGGGTGATLTMILSKYPTIRCINFDLPHVIEDAPEYPGIEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKLLKNCYDALPNNGKVILAECILPEVPDSSLATKGVVHIDVITVAHNPGGKERTEKEFEALAKAAGFQGFQVFCNAFNTYIIEFSKKICN
Protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) (O43150)
Organism: Homo sapiens (Human)
Function: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Subcellular location: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups.
Interaction partners:
- ADP-ribosylation factor 6
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
- Protein-tyrosine kinase 2-beta
- Paxillin
- ADP-ribosylation factor 5
- Poly
- SH3 domain-containing kinase-binding protein 1
Sequence:
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
Protein: Receptor-type guanylate cyclase gcy-12 (EC 4.6.1.2) (Q19187)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:21124861, ECO:0000269|PubMed:26434723}. Perikaryon {ECO:0000269|PubMed:26434723}. Cell projection, dendrite {ECO:0000269|PubMed:26434723}. Note=Localization in cilium of sensory neurons is regulated by daf-25 (PubMed:21124861). Cilia localization may be important for regulating body size (PubMed:21124861). Localizes to small puncta around the nucleus in the perikaryon (PubMed:26434723). Enriched at the proximal segment of the cilia or at the distal dendrite tip close to the cilia (PubMed:26434723). {ECO:0000269|PubMed:21124861, ECO:0000269|PubMed:26434723}.
Interaction partners:
- Probable 3',5'-cyclic phosphodiesterase pde-2
- Bis
- Inosine triphosphate pyrophosphatase
- Dauer abnormal formation protein 25
- Probable 3',5'-cyclic phosphodiesterase pde-5
- Probable 3',5'-cyclic phosphodiesterase pde-1
- Probable 3',5'-cyclic phosphodiesterase pde-3
- GTP cyclohydrolase 1
- Cyclic nucleotide-gated channel
Sequence:
MWPTSVEALRFYHTFAFSPGRRRRLFGLSIVFVIAALCVTSCDADAVPAPSPEAEPSLGAGANPYLLDSLVKRLPKKGDKKEILISYLAAVPTLMGEIDQYLLNLSASNSAQNSSKDRESFSKKLNQIVHCLTTDAYVSVVSGALVAAIVEINQDKDLIPAYQLKYVFGNTCGNDSHSTRLFMEHWQAGARVFIGPEKNCKTEAAMAASQNLPIISYRCNDQDISRDDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRKFSVVYDVKKGQVKNELFETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKSTMQTTRIYLTFDNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNVYHSMNNHFLRNTMTYLHHSWDANNSSDRKMLDYARSALSIIPTPVKLNSQRFYNFWKKAGDYMHHFGVQKADNLKGNRIACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDMRIDERGNSKGNFSLLSWQKVAPIMNKSDPSYYPLDHALDLTAIFVEAPDKDRLPNLQFKSSRIQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTLNYIRSRRFEKELSMIWKIDPYEVRRVVGGVNNESTASLMQSDVMQFAKTKTPWWSKAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGRAGYEFTETIEDKMVVPDIFPRPNLKNRGSSWGVNRESSLSLATEKSSQIMKRQSAAMNRNNQDVIYYNQPLNSGGFTSRGTSNREMPKLYEEDRESLLNQSASLLGSRTSGRKKSTASKYNGFSASRMFSSTISNASSSRPSRPSTFDHDTLALRKRSTSLPDGEKLNLEFIETTNLANNSVPAIPNNISSLEPVFRKASIIDGYSSQSESPSQSQYPSYRDLTTGPHQRKRGIATVFPVRKRSLSCGDAVPLKINENGASGSITTAVSPRSSCRALDPTMKLAARASSPDEIIFQEDDEDALIDNDSLLTSNGNSKSEDVLRTCPQPRRKNKHSFLRDPSPLAKRFRDASPFGKKKPFWNSNKSNEHTSSPADSISRLFRRFRGGSVNEYADLNHYCDDEDESGRANGYEMQEMGKMTGRQREQRNGSRTNRSVSCSPDECGTLTDSSDPHLTIPSSSIGDSSASTSLSCS
Protein: AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) (Q9BXS5)
Organism: Homo sapiens (Human)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Interaction partners:
- AP-1 complex subunit beta-1
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit gamma-1
- AP-1 complex subunit sigma-2
- AP-1 complex subunit sigma-3
- AP-1 complex subunit gamma-like 2
- ADP-ribosylation factor 1
- AP-2 complex subunit beta
- AP-1 complex subunit mu-2
- HLA class I histocompatibility antigen, A alpha chain
Sequence:
MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTQ
Protein: Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) (P60906)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Ancillary SecYEG translocon subunit
- Aspartate--tRNA ligase
- Arginine--tRNA ligase
- Leucine--tRNA ligase
- Isoleucine--tRNA ligase
- Threonine--tRNA ligase
- Methionine--tRNA ligase
- Valine--tRNA ligase
- Lysine--tRNA ligase
- Lysine--tRNA ligase, heat inducible
Sequence:
MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG
Protein: Protein lin-28 (Abnormal cell lineage protein 28) (P92186)
Organism: Caenorhabditis elegans
Function: Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Through this regulatory role, controls the timing of the sexual maturation of the nervous system. Also has a role in the fox-1-sex-1-mediated determination of sexual fate. Plays a role in governing the developmental timing of male tail tip morphogenesis. Plays a role in controlling the seam cell number during larval stages. Plays a role in vulval development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26811380, ECO:0000269|PubMed:9054503}.
Interaction partners:
- Protein lin-14
- Transcription factor sox-2
- Protein lin-41
- PAP-associated domain-containing protein
- Hunchback-like protein
- Heterogeneous nuclear ribonucleoprotein A1
- Ribonuclease 3
- Glycine-rich cell wall structural protein
- LIN-46
- Zinc finger transcription factor lin-29
Sequence:
MSTVVSEGRNDGNNRYSPQDEVEDRLPDVVDNRLTENMRVPSFERLPSPTPRYFGSCKWFNVSKGYGFVIDDITGEDLFVHQSNLNMQGFRSLDEGERVSYYIQERSNGKGREAYAVSGEVEGQGLKGSRIHPLGRKKAVSLRCFRCGKFATHKAKSCPNVKTDAKVCYTCGSEEHVSSICPERRRKHRPEQVAAEEAEAARMAAEKSSPTTSDDDIREKNSNSSDE
Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q581G5)
Organism: Trypanosoma brucei
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVTFMRELYVRDGAFTYLVFSLLLQVLTASSLANDKIQVKVYNMLYSNKISAKIYDPITAGFNASITNGNTPSGANVEVVYVPPMDDSKYADYLGKHMTTHDGKELPVILGPVGDKNTLGLLKYFKEKNVISFSPLTGSSKVRSWNPNLYFLTASPAAEMLALLRYAITQLRLHRLGFMYLKDVSYGDDEYELAVELTTRMDRKLCGVFALKSQIGKESDDSSFSAEWNKFANTRPQGVIVFGSPINDTKKFLMKSLEDERTKGGYLLIPSTLQYVIENKWEKELGRDRFVPDKIIITGTNPLAKDDGYDAIKRFKGDMAKYLKEKKDILSGTGQWNVNLNVDESNFTEQDTEAELMVDGWIAGEVLKQALSCREWLTSRDAFITSLYNQRRYVIDDIVVGDFGGECRGMAGERGASCLCNQGGNVVYMKKMGKDLRLYPMKEGVLALTSSRCYRDLSQLYAPLSGIMFKLTDDPKALRTAEAIYDGAFYVVGKGQLGHSDRFFLHWLSSKSHDTSTALYDEVEKRVVTAVFGVVDDSLLSTKGMAFIDPITLTPQLSNPRRNVIHLSPTLEQQLFVIVEHIIQNGAGKMHAIVRSGDTRGVRKVLQKTLDFFESSLSSFVASGEGSTLRDKLPTAGEVLVAGLISDDIPIILSHLGKHHNVRIFVPFFDVALLYDELVSAFRDKPFADRLLFATNLPHWGDKNTKSDMVREFHRVVRDESKWKPLSLLGYVTARAMINILQRMGHVTPEELVDAIFSQSVITVDDMRYGPFDDKCTNGASFEEKHCAVNYGATHISVWSMSRVLNPSVSPVVTHVTPSMKYGDTEGFRLKRGHIAAIAVSCVVVLALFVTVLVLVSASRRNARDNNNAPKEPTDPVTLIFTDIESSTAQWAAHPEQMPDLVATHHRLIRSLITRYECYEVKTVGDSFMIACKSPFAAAQLACDLQRDFLNHDWKTTELDESYREFERKRAEDDSDYTPPTASLDPEVYRQLWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRTSNMAARTESVGNGGQVLMTRSTYLSLSGEEREQLNVTPLGDVPLRGVPKPVEMYQLNAVPGRTFAALRLDREFEEEEDNVTGSITSGSGSPERGLTATAQQVAGCIDALLGTFPATQRQKMLATFCERWRVKKPPGMDAWNEASCRCVTRRIAAKVGCVMDFGTRNTSGSVPSFERGGSFFSLGGVAAAIMLSSSSNSFCGEGDCSGVQLIDLDNVSAAS
Protein: DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) (Q21554)
Organism: Caenorhabditis elegans
Function: Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-4
- DDB1- and CUL4-associated factor 11 homolog
- RING-box protein 1
- WD_REPEATS_REGION domain-containing protein
- CULT domain-containing protein
- DDB1- and CUL4-associated factor homolog 1
- CDT1 Geminin-binding domain-containing protein
- Uncharacterized WD repeat-containing protein F47D12.9
- Ubiquitin-like protein NEDD8
- RING-box protein 2
Sequence:
MPISYCVSAKKASVVVESVVGNFTGHENVNLIVARGNRIDVQLVSPEGLKNVCEIPIYGQVLTIALVKCKRDKRHSLIVVTEKWHMAILAYRDGKVVTRAAGCIADPTGRATDNLFSLTIHRNGLIAIRAFEGSVKMIQWESGTDLRHFNVRFDYPNVSDFKFVDTGEDDVYRVAFIYDDDHGKHLQFSDLNMHDKEFRTYSRQASIAADSSVLIPVPHAIGGVIVLGSNSVLYKPNDNLGEVVPYTCSLLENTTFTCHGIVDASGERFLLSDTDGRLLMLLLNVTESQSGYTVKEMRIDYLGETSIADSINYIDNGVVFVGSRLGDSQLIRLMTEPNGGSYSVILETYSNIGPIRDMVMVESDGQPQLVTCTGADKDGSLRVIRNGIGIDELASVDLAGVVGIFPIRLDSNADNYVIVSLSDETHVLQITGEELEDVKLLEINTDLPTIFASTLFGPNDSGIILQATEKQIRLMSSSGLSKFWEPTNGEIISKVSVNAANGQIVLAARDTVYLLTCIVDEMGALDIQLTAEKKFENEIACLDLSNEGDDPNNKATFLVLAFWSTFAMEVIQLPDLITVCHTDLPTKIIPRSIIATCIEEVHYLLVAFGDGALVYYVFDIKTGTHGEPKKSNVGTRPPSLHRVRNKNRQHLFVCSDRPVIIFSASKKLVFSNVNVKLVDTVCSLSSSAYRDCLVISDGNSMVFGTVDDIQKIHVRSIPMGESVLRIAYQKSTSTYGVCSNRTESKAERVFASKNALVTSQSRPKVASTRADMDESPPNTTSSFMVLDQNTFQVLHSHEFGPWETALSCISGQFTNDSSTYYVVGTGLIYPDETETKIGRIVVFEVDDVERSKLRRVHELVVRGSPLAIRILNGKLVAAINSSIRLFEWTTDKELRLECSSFNHVIALDLKVMNEEVAVADVMRSVSLLSYRMLEGNFEEVAKDWNSQWMVTCEFITAESILGGEAHLNLFTVEVDKTRPITDDGRYVLEPTGYWYLGELPKVMTRSTLVIQPEDSIIQYSQPIMFGTNQGTIGMIVQIDDKWKKFLIAIEKAIADSVKNCMHIEHSSYRTFVFQKRAEPPSGFVDGDLVESILDMDRSVAMDILSKVSDKGWDPSLPRDPVEILKVIEDLARMH
Protein: Putative cell agglutination protein pfl9 (Adhesin pfl9) (Pombe flocculin 9) (Q9P7Q2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular location: Cell surface {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C553.10
- Uncharacterized protein PB18E9.04c
Sequence:
MNVVKYIIFSFALAPLLLVNANTYNFTQIQKRSVNQAVLESSQDTNSVGGEASSTACPLFTTIYTNGITPGTTTIYPTSISTSGVSSNNIDETSVSSESIITSTITTTITSGSQLYTTTITGQNTPVDTVEVVIPTAGTFTTTLTSGSSYPVATTTVRTASGTQSGEVEVITPSCGCSPENSFHLKIDNDKISPSYVYMDPNAPVRTNGAGREGNMFASTNGDNEGLNLFYYDSTIQRVLTCDCQRPSYTVYIEDPIIGNGFSSAWNLIKNSDGIFTPVESRNNEPLHFHVDNNGRVWMTSQEYDTEVSSTDERNFRANDVTLQLY