wanglab/gogpt-training-data huggingface dataset:
Protein: Wolframin ER transmembrane glycoprotein (A0A8I6A452)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSSGTPPPSPSGPPPPPAPQPQARARLNATTSLEQDKIEPPRAPRPQPDSSAGRSAGEATTPEPWAPHASSREGTDKAGPMKADVEIPFEEILEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPNNLFLQDEDEDEDELSGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVVSAFFTVTSYMSLSSSAEPYTRRALVTEVAAGLLSLLPTMPVDWPFLKALGQTFFTVPIGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICSVPLLFRWWTKANFSVVGMVKSLTRSSIVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKCLLPIPVCRLRSVCHWRTPRCMLL
Protein: DNA repair protein RAD51 homolog 3 (J9PFC8)
Organism: Oryza sativa (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEIADLPIATSHRANLLAAGYSSLAALSAASPPRLARDLSIEVHEAEEILKVAVGANKSKGADGPSTSSVLKGVQNAWDMLSDEQSRRHINTGSADLNNILGGGIHCKEVTEIGGVPGVGKTQLGIQLAINVQIPVEYGGLGGKAVYIDTEGSFMVERVYQIAEGCISDILEYFPHCHDKAPAGQEKLKPESFLADIYYFRICSYTEQIAVINYLEKFLGEHKDVRIVIIDSVTFHFRQDFDDMALRTRVLSGLSLKLMKLSKAYNLAVVLLNQVTTKFTEGSFQLTLALGDSWSHSCTNRLILYWNGNERYGFLDKSPSLPVASAPYAVTVKGVRDAVNSNSKRVRVM
Protein: Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (Q658N3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
Protein: FUN14 domain-containing protein fndc-1 (Q22252)
Organism: Caenorhabditis elegans
Function: Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage.
Subcellular location: Mitochondrion outer membrane {ECO:0000305|PubMed:31233739}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Serine/threonine-protein phosphatase Pgam5, mitochondrial
- Protein lgg-2
- Protein lgg-1
- Tyrosine protein-kinase src-1
- Casein kinase II subunit alpha
- Casein kinase II subunit beta
- Mitochondrial prohibitin complex protein 2
- Serine/threonine-protein kinase pink-1, mitochondrial
- E3 ubiquitin-protein ligase parkin
- TBC1 domain family member 15
Sequence:
MVDLSKNDGGSGKAGKGVSDAIDTVLYYVVDLKKQQPMVQLGVGAGFGTVTGYFVTKGGRLVAATVGISFLLAQFAIHKGYITLNESKIERDMKNLHKSVMNKVSGKKVINISDSFVSEYRWILGGFAAGMLIGFSVA
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (A0A151CBU1)
Organism: Bifidobacterium bifidum
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00318}. Secreted {ECO:0000256|HAMAP-Rule:MF_00318}. Cell surface {ECO:0000256|HAMAP-Rule:MF_00318}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. {ECO:0000256|HAMAP-Rule:MF_00318}.
Interaction partners:
Sequence:
MAAIESVYARQILDSRGNPTVEVILDTEDGAEGRGLVPSGASTGEAEAWERRDGDKSVYGGKGVLNAVKAVNEVIAPKVIGMDATDQRALDDLMIELDGTPNKGKLGANAILGVSLAALYASAESAELPLYRYIGGTNGHILPVPNMNIMNGGAHADFATDIQEYMISPYGFDTYSEALRAGVEVYHTLKNVLKKEGLNTGLGDEGGFAPKMKSNEDSLKYIMDAISAAGYEPGKQIGICLDVASSEFYNKETGKYRFDGEERDSAYMLDYYENLINEYPIVSIEDPFNEEGWEDWAEITRRLGDRLQFVGDDLLVTNPARLRKAIDMGAANSLLVKLNQIGSVTETLDAIELATENGYTSMVSHRSGETPDTTISDLAVAKNTRQIKTGAPARGERVAKYNRLLEIEEELGSTAQYAGYSAFKACKKYIAK
Protein: NADPH--cytochrome P450 reductase 2 (CPR 2) (P450R 2) (EC 1.6.2.4) (Q9SUM3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and dichloroindophenol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
Interaction partners:
- Carotene epsilon-monooxygenase, chloroplastic
- Assimilatory sulfite reductase
- Ferredoxin--nitrite reductase, chloroplastic
- Anamorsin homolog
- Zim17-type zinc finger protein
- Cytochrome P450 97B3, chloroplastic
- MND1-interacting protein 1
- At1g47620
- AT2G17320 protein
Sequence:
MSSSSSSSTSMIDLMAAIIKGEPVIVSDPANASAYESVAAELSSMLIENRQFAMIVTTSIAVLIGCIVMLVWRRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW
Protein: Protein TIFY 6a (OsTIFY6a) (Jasmonate ZIM domain-containing protein 3) (OsJAZ3) (OsJAZ9) (Q6ZJU3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Repressor of jasmonate responses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Transcription factor MYC2
- Coronatine-insensitive protein homolog 1b
- Os10g0506950 protein
- Coronatine-insensitive protein homolog 1a
- Transcription factor BHLH062
- Coronatine-insensitive protein homolog 2
- Protein NINJA homolog 1
- Transcription factor
- Transcription factor
- Protein TIFY 9
Sequence:
MERDFLGAIWRKEEAAGKPEEHSDYRGGGGGASAAMQWQFPATKVGAASSAFMSFRSSAAAAREEDPKEAAVFDRFSLSGFRPPPRPSPGDAFDGAAAMKQRQFGFNGRQQYAAAAQHGHREQGVDSYGVAAPHHFPSPSPSPRHPVPFGHANPMLRVHSLPNVAGGSPYRNQSFSVGNSVAGSTVGVYGGPRDLQNPKVTQMTIFYDGLVNVFDNIPVEKAQELMLLASRASIPSPPSAARKSDSPISAAAKLTVPEALPARQIVVQKPEASVPLVSGVSNPITIVSQAVTLPKSFSSSNDSAGPKSGGLPLAVTPLSQASPSQPIPVATTNASAIMPRAVPQARKASLARFLEKRKERVSSVAPYPSSKSPLESSDTIGSPSTPSKSSCTDITPSTNNCEDSLCLGQPRNISFSSQEPPSTKLQI
Protein: GRAS family protein RAD1 (Protein REQUIRED FOR ARBUSCULE DEVELOPMENT 1) (MtRAD1) (G7JMM0)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Transcription factor acting as a regulator of arbuscular mycorrhiza (AM)-related genes (e.g. STR). Required for the morphogenesis of arbuscules upon symbiosis with AM fungi (e.g. Glomus versiforme). Also involved in restricting mycorrhizal colonization of the root meristem (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:G7L166}.
Interaction partners:
- Blue copper protein 1a
- Inhibitor of trypsin and hageman factor-like protein
- Elongation factor 1-alpha
- 1-phosphatidylinositol 4-kinase
- Peroxidase
Sequence:
MSPALYASTFKCEVDENPSLMGSYYASLYPNLPILENSATSTWILNPFSDHETETIRDHKKLKRSTVTIPIWFANFSSHSNSFFNNINSNNNSVNSIPRLHFRDHIRTYKQRYFASEAVEEAAEDNFNYNNCEAEEDGSCADGMRLVQLLIACAEAVACRDKSHASVLLSELKSNALVFGSSFQRVASCFVQGLTERLTLIQPIGNNSAGSDTKSMMNIMDAASEEMEEAFKLVYENCPHIQFGHFVANSIILEAFEGESFLHVVDLGMSLGLPHGHQWRGLIQSLADRSSHRVRRLRITAIGLCIARIQVIGEELSIYAKNLGIHLEFSIVEKNLENLKPKDIKVNEKEVLVVNSILQLHCVVKESRGALNAVLQMIHGLSPKVLVMAEQDSGHNGPFFLGRFMESLHYYSAIFDSLDAMLPKYDTKRAKMEQFYFAEEIKNIVSCEGPLRMERHEKVDQWRRRMSRAGFQGSPIKMVVQAKQWLVKNNVCDGYTVVEEKGCLVLGWKSKPIVAVSCWKC
Protein: Cold shock-like protein CspLA (CspL) (P0A355)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit beta
Sequence:
MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQGDGFKSLDEGQAVTFDVEEGQRGPQAANVQKA
Protein: Neuronatin (Q62649)
Organism: Rattus norvegicus (Rat)
Function: May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.
Interaction partners:
- Apoptosis inducing factor BLCAP
- Epsilon-sarcoglycan
- Lost on transformation
Sequence:
MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAHTVSRTGRQVLGERRHRAPN
Protein: Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) (P82347)
Organism: Mus musculus (Mouse)
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:9864373}; Single-pass type II membrane protein {ECO:0000269|PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9864373}.
Interaction partners:
- Alpha-sarcoglycan
- Dystroglycan 1
- Beta-sarcoglycan
- Dystrophin
- Gamma-sarcoglycan
- Sarcospan
- Dystrobrevin alpha
- Utrophin
- Epsilon-sarcoglycan
- Filamin-C
Sequence:
MPQEQYSHHRSTMPSSEGPHIYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIKSRPGNALYFKSARNVTVNILNDQTKVLTQLVTGPKAVEAYGKRFEVKTVSGKLLFSADDSEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEAICRSELRLESKDGEIKLDAAKIKLPRLPRGSYTPTGTRQKVFEVCVCANGRLFLSQAGTGSTCQINTSVCL
Protein: AbiTii domain-containing protein (Q8NPJ8)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Cell wall synthesis protein Wag31
- DUF4287 domain-containing protein
- UPF0324 membrane protein Cgl0015/cg0018
Sequence:
MIFSMTDSLLVSIRKGLIEERPLTELLRACIFLGSDTNSDSLQEWAKNELNGYGSIDGIPEYRKLKGPPVFAKIQAGNSIMSNMVLGPHNVPERARKYFPEELHFDQPIQTLIEWSTRQDGINLSPPNLLRVRDLHNDQYAPLNQILNLNVYLDNSYFSGIVDRIRTLMTSMIADLTHATPLDELPSSEKVNATVMKHIENNYETTITQANGAVAIGNSAKAVQKGLSVDDLLKIMQTINPEKFDLGEARAEAEESIQSIADELKKESPNKGFIQNAFEKLKELSIKAGDKAFTTMLNLVGKQIIENIPQLVSGG
Protein: Wiskott-Aldrich syndrome protein family member (WASP family protein member) (Q9VKM2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}.
Interaction partners:
Sequence:
MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIGDRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQCDKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAAGRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGNMGVYDTRPPRPNSIELNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQMYDAGMYQSHALYGQTGQGVMSPEPIYGPGTPSRNKPRPSQPPPAPPSNGSGGGTPTASNANTPTRGRSMSTSRDALPPPPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNTFHSIGMTGNQLNSLSDLPPPPPVPDQHSPKMSPPNAAPPPPPPPPPVEEGMGSGNQHTLRPHQILPKSLANGEMQQPGQQNGVPHIVAPKKMLPPFHDPRNDLMKAIRDGITLRKVEKSEQKEIERNAAPLDVASILARRVAIELSESEDSDSEDDSEGWMEPNETSA
Protein: Protein N-terminal and lysine N-methyltransferase EFM7 (EC 2.1.1.-) (Elongation factor methyltransferase 7) (Nicotinamide N-methyltransferase-like protein 1) (Q05874)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3'. May be involved in rDNA silencing and in lifespan determination.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03223, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein-lysine N-methyltransferase EFM6
- Protein-lysine N-methyltransferase EFM5
- Protein-lysine N-methyltransferase EFM4
- Protein-lysine N-methyltransferase EFM2
- Protein-lysine N-methyltransferase EFM1
- Alpha N-terminal protein methyltransferase 1
- Elongation factor 1-alpha
- Ribosomal lysine N-methyltransferase 5
Sequence:
MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWGHLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQNIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEHHKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFDEDEETIEVRSRVYAYYLTHEK
Protein: Glucan 1,3-beta-glucosidase 2 (EC 3.2.1.58) (Exo-1,3-beta-glucanase 2) (P52911)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Glucan 1,3-beta-glucosidase
- Glucan 1,3-beta-glucosidase I/II
- Sporulation-specific glucan 1,3-beta-glucosidase
- 1,3-beta-glucan synthase component FKS1
- Invertase 2
- 1,3-beta-glucan synthase component FKS3
- 1,3-beta-glucan synthase component GSC2
Sequence:
MPLKSFFFSAFLVLCLSKFTQGVGTTEKEESLSPLELNILQNKFASYYANDTITVKGITIGGWLVTEPYITPSLYRNATSLAKQQNSSSNISIVDEFTLCKTLGYNTSLTLLDNHFKTWITEDDFEQIKTNGFNLVRIPIGYWAWKQNTDKNLYIDNITFNDPYVSDGLQLKYLNNALEWAQKYELNVWLDLHGAPGSQNGFDNSGERILYGDLGWLRLNNTKELTLAIWRDMFQTFLNKGDKSPVVGIQIVNEPLGGKIDVSDITEMYYEAFDLLKKNQNSSDNTTFVIHDGFQGIGHWNLELNPTYQNVSHHYFNLTGANYSSQDILVDHHHYEVFTDAQLAETQFARIENIINYGDSIHKELSFHPAVVGEWSGAITDCATWLNGVGVGARYDGSYYNTTLFTTNDKPVGTCISQNSLADWTQDYRDRVRQFIEAQLATYSSKTTGWIFWNWKTEDAVEWDYLKLKEANLFPSPFDNYTYFKADGSIEEKFSSSLSAQAFPRTTSSVLSSTTTSRKSKNAAISNKLTTSQLLPIKNMSLTWKASVCALAITIAALCASL
Protein: Solute carrier family 3 member 2 (F5GZS6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSETGSDCVTQAGLQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA
Protein: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (A0A0R4IR84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00037848}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00037848}.
Interaction partners:
- D-glucuronyl C5-epimerase B
- heparosan-N-sulfate-glucuronate 5-epimerase
- Exostosin glycosyltransferase 2
- Exostosin-like 3
- [heparan sulfate]-glucosamine N-sulfotransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Heparan sulfate 2-O-sulfotransferase 1
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Extracellular sulfatase.
Sequence:
MMLMCGRVRRLFRQLTLQTSLLLLFLFCMVSVLISAYFLYGVKRELEPAGAGGVVVPEEGTADWEDPRATPSPPSARVLPARTAKPADMSRTDPVVLVFVESLYSQLGQDIVAILESGRFRYQTEIAPGKGDMPTLTDKNRGRFTLVIYENILKYVNLDAWNRELLDKYCVEYGVGIIGFFKANENSLQSAQLKGFPLFLHSNLGLRDCSVNPKSPLLFITKAREVEHGPLPGDDWTVFQSNHTTYEPVLLARGRSTEASGAPGPLHAAVVQDLGLHDGIQRVLFGNNLNFWLHKLVLVDAVSFLTGKRLSLALERYILVDIDDIFVGKEGTRMKVSDVKALLETQNELRNHVPNFTFNLGFSGKFFHAGTDEEDLGDDLLLSYSKEFWWFPHMWSHMQPHLFHNQSVLAEQMLLNHKFAEEHGIPTNMGYAVAPHHSGVYPIHLQLYEAWKKVWGIKVTSTEEYPHLKPARFRRGFVHSGISVLPRQTCGLFTHTIFYNEYPGGSKELDKLIYGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKNLVKFVQMWTNLSLQTLPPVQLAQKYFQIFPEERDPIWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLSMHSDLTSNYPSKETFEEIQFFNGRNYHKGIDWYMEHFPLPSNTSSDFYFEKSANYFDSEVAARRAAALLPKAKIITILINPADRAYSWYQHQRAHDDPVAQKYTFHDVITAGRDAPIKLRVLQSRCLVPGLYATHLQRWLTHYHPSQILVLDGQMLRTEPASVMDKIQKFLGLINTLNYHKILAFDPKKGFWCQLLDGGKTKCLGKSKGRRYPDMDVDSRTFLREYYHEHNIELSKLLYKMGQPLPSWLREELLHSR
Protein: Chorismatase (EC 3.3.2.13) (Chorismate hydrolase) (Q9KID9)
Organism: Streptomyces hygroscopicus
Function: Involved in the biosynthesis of the macrocyclic amino acid-linked polyketides FK506 and FK520 which are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Catalyzes the hydrolysis of chorismate via a 1,4-conjugate elimination of water to yield (4R,5R)-4,5-dihydroxycyclohexa-1,5-dienecarboxylic acid (DCDC).
Interaction partners:
Sequence:
MTDAGRQGRVEALSISVTAPYCRFEKTGSPDLEGDETVLGLIEHGTGHTDVSLVDGAPRTAVHTTTRDDEAFTEVWHAQRPVESGMDNGIAWARTDAYLFGVVRTGESGRYADATAALYTNVFQLTRSLGYPLLARTWNYVSGINTTNADGLEVYRDFCVGRAQALDEGGIDPATMPAATGIGAHGGGITCVFLAARGGVRINIENPAVLTAHHYPTTYGPRPPVFARATWLGPPEGGRLFISATAGILGHRTVHHGDVTGQCEVALDNMARVIGAENLRRHGVQRGHVLADVDHLKVYVRRREDLDTVRRVCAARLSSTAAVALLHTDIAREDLLVEIEGMVA
Protein: Myeloblastin (EC 3.4.21.76) (Proteinase 3) (PR-3) (Q61096)
Organism: Mus musculus (Mouse)
Function: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P24158}. Secreted {ECO:0000250|UniProtKB:P24158}. Cell membrane {ECO:0000250|UniProtKB:P24158}; Peripheral membrane protein {ECO:0000250|UniProtKB:P24158}; Extracellular side {ECO:0000250|UniProtKB:P24158}. Membrane raft {ECO:0000250|UniProtKB:P24158}; Peripheral membrane protein {ECO:0000250|UniProtKB:P24158}; Extracellular side {ECO:0000250|UniProtKB:P24158}. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils. Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration. Following secretion tethered to the cell membrane by CD177. {ECO:0000250|UniProtKB:P24158}.
Interaction partners:
- Myeloperoxidase
- Cathepsin G
- Neutrophil elastase
- CD177 antigen
- Lactotransferrin
- Cathelicidin antimicrobial peptide
- Antileukoproteinase
- Endothelial protein C receptor
- Matrix metalloproteinase-9
- Neutrophil gelatinase-associated lipocalin
Sequence:
MSGSYPSPKGIHPFLLLALVVGGAVQASKIVGGHEARPHSRPYVASLQLSRFPGSHFCGGTLIHPRFVLTAAHCLQDISWQLVTVVLGAHDLLSSEPEQQKFTISQVFQNNYNPEENLNDVLLLQLNRTASLGKEVAVASLPQQDQTLSQGTQCLAMGWGRLGTQAPTPRVLQELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLICNGILHGVDSFVIRECASLQFPDFFARVSMYVDWIQNVLRGAEP
Protein: Transducin/WD40 repeat-like superfamily protein (F4KIH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transducin/WD40 repeat-like superfamily protein
- At5g57460
- Vesicle-associated protein 4-2
- Calcium-binding EF hand family protein
- Calcium-binding EF hand family protein
- Protein transport protein SEC31 homolog B
- Transducin/WD40 repeat-like superfamily protein
- Beta-adaptin-like protein B
- Vesicle-associated protein 2-1
- AP-2 complex subunit alpha-1
Sequence:
MLRARAFRQTNGKIVKIQVHPTHPWLVTADDSDHVSVWNWEHRQVIYELKAGGVDERRLVGAKLEKLAEGESDYKAKPTEAIRGGSVKQVKFYDDDVRYWQLWRNRSAAAESPSAVNHLTSAFTSPAPSTKGRHFLVICCENKAIFLDLVTMRGRDVPKQELDNKSLLCMEFLSRSSGGDGPLVAFGSTDGVIRVLSMITWKLARRYTGGHKGSIYCLMNFMASSGEALLVSGGSDGLLVLWSADHGADSRELVPKLSLKAHDGGVVAVELSRVSGSAPQLITIGADKTLAIWDTMTFKELRRIKPVPKLACHSVASWCHPRAPNLDILTCVKDSHIWSIEHPTYSALTRPLCELSSLVPPQVLATHRKLRVYCMVAHPLQPHLVATGTNVGIIVSEFDPRAIPSAAPLPALPGSRENSAIYILGRELKLLNFQLSNTANPSLGNNSALSESGLSKGDPGEQLTVKQTKKQIVAPVPHDSYSVLSVSSSGKYVAVVWPDILYFSIYKVSDWSIVDSGSARLLAWDTCRDRFAILESVLPHRMPIIPKGGSSRKAKEAAAAAAQAAAAASAASSASVQVRILLDDGTSNILMRSVGGRSEPVIGLHGGALLGIGYRTSRRISPVAATAISTIQSMPLSGFGNSNVSSFSSYDDGFSSQKSAESAPLNYQLYSWENFEPVGGMLPQPEWTAWDQTVEYCAFAYQQYMVISSLRPQYRYLGDVAIAHATGAVWHRRQLFVATPTTIECVFVDAGVSEIDIETRKMKEEMKLKEAQARAVAEHGELALITVEGSQAAKQERISLRPPMLQVVRLASFQNAPSVPPFLSLPRQSRGDSDDIMDERRVNEVAVGGGGVSVAVTRFPVEQKRPVGPLVVAGVRDGVLWLIDRYMCAHAISLNHPGIRCRCLAAYGDAVSAVKWASRLGREHHDDLAQFMLGMGYATEALHLPGISKRLEFDLAMQSNDLKRALHCLLTMSNSKDIGQDGVGLDLSDILSLTATKKEDVVEAVEGIVKFAKEFLDLIDAADATGHADIAREALKRLATAGSVKGALQGHELRGLSLRLANHGELTRLSGLVNNLISIGLGRESAFSAAVLGDNALMEKAWQDTGMLAEAVLHAHAHGRPTLKNLVQAWNKTLQKEVEKAPSSKTDAASAFLASLEDPKLTSLSDASRKPPIEILPPGMSSIFASITAPKKPLLTQKTAQPEVAKPLALEEPTKPLAIEAPPSSEAPQTESAPETAAAAESPAPETAAVAESPAPGTAAVAEAPASETAAAPVDGPVTETVSEPPPVEKEETSLEEKSDPSSTPNTETATSTENTSQTTTTPESVTTAPPEPITTAPPETVTTTAVKPTENAATERRVTNYPPIRSQPIDFDFLNG
Protein: Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3767c (EC 2.1.1.-) (P9WFH5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Interaction partners:
- Phosphoribosylformylglycinamidine synthase subunit PurS
- Probable short-chain type dehydrogenase/reductase
- Uncharacterized protein
- S-adenosyl-L-methionine-dependent methyltransferase
Sequence:
MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDAAGDGIWSMYTNRTLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFLATADAGVRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATLRQHGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPARAQDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMRAAAAKLVETEISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPELLARYGRSIPHSGEDSIPPNLFVSAQRATS
Protein: Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB (P32011)
Organism: Streptomyces peucetius
Function: Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9006006}; Multi-pass membrane protein {ECO:0000269|PubMed:9006006}.
Interaction partners:
Sequence:
MTTSPGTVESTTPVSGQLRTVLSAGERPARATAVSATLTHLWRAMMAFKHFPVQLIDIVLMPLIFLLMFTYLFGGAFADSTEEYLQFYLPGVTVQAVVMMTVYTGTSLNTDIHKGVFDRFRTLPFWQPATLAGSLLGDVLRYVVALATTVSLGLLLGFRADGGFLGVVGAMLVLIVFGFSVSWIFAALGVVASEPERVSGTSMIVLYPLLFMSNIFVMPETMPGWMQAIVDANPMSHAATASRELMHGTAGFWDVGLVLCVSAGLVAVFAPLTMRLYRNKNAH
Protein: tRNA A64-2'-O-ribosylphosphate transferase (EC 2.4.2.-) (Initiator tRNA phosphoribosyl-transferase) (P23796)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: tRNA backbone modifying enzyme that mediates initiator/ elongator tRNA discrimination. This enzyme modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. Recognize the stem-loop IV region that is unique in eukaryotic cytoplasmic initiator tRNAs.
Interaction partners:
- Exportin-T
- tRNA wybutosine-synthesizing protein 3
- Putative uncharacterized protein YMR031W-A
Sequence:
MVSRLSKRYRSRVQFSISVMDENIYLSLSQINKDIRKENKSVRNRLQSILLDNKFLQDRVIPIFPHYPLIPNERCGLWYCNPSSFKQTSYFKSTDGHVNQWDFSTRRLNFHLLETIRDNKGIIIVDSTRRGKKIPDALSKTVPIWCAVLNTLMLQETEKNVAIDKVLYLPPETVPKSEYDMIKRKIPELVAKLQKLNIIDSKKLNELFMGKLLRPIWVHPGSSLLDHSVDYFTGEVQEYEAWETPEDQNIIPIILCTVSYQAQDGMDKRYGFTYVQGAADDHELWSFGLDSNMFWAHIEYLGDASYSDDQLHDYIMDLAAAKLRNQCYIQDKGSLDEVFGNIDKITNEISLGKVSSGLTINKNLKQKLKSEYGKVIIFSNSVTVAEDTDDEEESGTDPFISIYKLQSGDKKSSKALRSTFPRIHGEIQSLFTNRDEKIKPMLICCNTGTDMSIGVILSILCTKYTEEWMLTSELPDISKLIVRKHLTKLISHLKGRNVNPSRATLNSVNSFLM