wanglab/gogpt-training-data huggingface dataset:
Protein: NADP-dependent oxidoreductase domain-containing protein (Q2U2M0)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- pyridoxal kinase
- NADP-dependent oxidoreductase domain-containing protein
- NADP-dependent oxidoreductase domain-containing protein
- NADP-dependent oxidoreductase domain-containing protein
- Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein
- pyridoxal 5'-phosphate synthase
Sequence:
MPSLVGRDVGHTGYGLMRMTWVPQPPPQEQCFEALNTALAHGSNFWNAGELYGTPEYNSLHLLHSYFAQHPENADKVVLSIKGGLKPGQLVPDGSEANIRRSVDECLRVLDGKKKIDIFECARQDPKTTVEQTVTVLAQLVKEGKIGGIGLSEVDAETIRRAHKVHPIAAVEVEMSLFDLTILQNDVAKVCAELNIPIVAYSPLGRGVLAGAFTTAADIPDGDFRKTLPKFQDEAMKQNIKLVNEVNDLAARKGVAPVQIALAWVLTLSGKPGMPTIIPIPGGTTSAKVAQNLQAPRLTDAEMAEIDAILKRNEIVGTRY
Protein: Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (A8E7C6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|PIRNR:PIRNR000631}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- GDNF family receptor alpha-1
- Glial cell line-derived neurotrophic factor
- GDNF family receptor alpha
- Docking protein 1b.
- Neurturin
- Neurturin
- GDNF family receptor alpha 4a.
- Artemin a.
- Artemin b.
- GDNF family receptor alpha 2b.
Sequence:
MGSTRGIVWGVLLLLLSEGSFGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSHRDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSPKDLTLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISNPHITENREPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSPYVNGTDTEDVLVEFDRSEGTVFGTLFVYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGNVRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGPEGTVLLHFNVTVLPVPIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDGYCDAIESKNISICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFEGKCFCERDEPEDDICNDMCKTVIATGIILSFIVSVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPSTWIENKLYGMSYPNWPEKSPVPLNRLDATNPVFTRYANDSVYANWMALHSPAKIVDTIDS
Protein: Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] (P00747)
Organism: Homo sapiens (Human)
Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Subcellular location: Secreted {ECO:0000269|PubMed:10077593, ECO:0000269|PubMed:14699093}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Interaction partners:
- Histidine-rich glycoprotein
- Alpha-2-antiplasmin
- Tissue-type plasminogen activator
- Alpha-enolase
- Fibronectin
- Annexin A2
- Tetranectin
- Vitronectin
- Pigment epithelium-derived factor
- Angiomotin
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Protein: Hypoxanthine/guanine phosphoribosyltransferase (HGPRTase) (EC 2.4.2.8) (Hypoxanthine (guanine) phosphoribosyltransferase) (O33174)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- GMP synthase subunit B
- Adenylosuccinate lyase
- GMP synthase subunit A
- Predicted ribokinase
- 2-
- 5'-nucleotidase SurE
- Adenine deaminase
- Putative adenylate kinase
- 5-formaminoimidazole-4-carboxamide-1-
- Adenylate kinase
Sequence:
MLDKLKESLRNSPVIKKGEYDYFVNPVTDGIPLTEPELLEEIADEIVRRFNPDPASVDKIVCIEAMGIHHATVLSLKTRIPFVVVRKRRYGLPGEVAVHQMTGYSEGELYINGVDGDDRVMVIDDVVSTGGTLLAVLEALREMEVEVVDVVTVIDKGEGSRVVKERTGFTVRSLVKADVVDGRVTVEDIPDGG
Protein: Expressed protein (Q8RUI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g49990
- Bystin
- Serine/threonine-protein kinase RIO2
Sequence:
MMLESSSKKRWNVNVLSSASSHRETIVLGRYSKSCREQKQHQRRERLLPKWKVLLMKLKLLPSRASSTKVVAYEPCDYSLNFDQGPGWHDHDEPENLSRSFSCRFADPTRIRETRFLLY
Protein: ATP citrate synthase (EC 2.3.3.8) (F4I5V8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQADDVFWLHSCFGFSDIRHHVINETTDLNELVEKEPWLSSEKLVVKPDMLFGKRGKSGLVALKLDFADVATFVKERLGKEVEMSGCKGPITTFIVEPFVPHNEEYYLNVVSDRLGCSISFSECGGIEIEENWDKVKTIFLPTGASLTPEICAPLVATLPLEIKAEIEEFIKVIFTLFQDLDFTFLEMNPFTLVDGSPYPLDMRGELDDTAAFKNFKKWGDIEFPLPFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASELGNYAEYSGAPKEDEVLQYARVVIDCATANPDGKSRALVIGGGIANFTDVAATFNGIIRALKEKEAKLKAARMHIFVRRGGPNYQKGLAKMRALGDDIGVPIEVYGPEATMTGICKEAIQYITAAA
Protein: Zinc finger and BTB domain containing 38 (A0A1B0GV48)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLEDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREHDGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGGSFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAPGTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEALKMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHSSQFSS
Protein: UPF0659 protein C216.03 (Q9Y7K0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial
- NADH-ubiquinone oxidoreductase 24 kDa subunit homolog C11E3.12, mitochondrial
- RNA polymerase I-specific transcription initiation factor rrn11
- Putative acyl carrier protein, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome b-c1 complex subunit 7
- Heme A synthase-mitochondrial ferredoxin fusion protein
- Cytochrome b-c1 complex subunit 8
Sequence:
MTVFVVFGGHGKVALLFTKIATEAGHIVYNVVRDYVQNEDIEKVHGRTSVCSLEKATPNDIAQFLAEIHPDVVIFAAGAGGKGGPERTRAVDYEGAIKVYDAMRIAGIRRLIMISAIDNRDMSQPPPPYYTAADIELSEKIHQSIGTYYHYKYLADQELVRRSSDIDWTILRPSGMTDEKGSGKVALGKISINCMMSRENVARTVLLFALDNQSIHLVVDMTDGNVPIYKAIAGFVVKGESSYTYSV
Protein: Nuclear polyadenylated RNA-binding protein nab2 (O13713)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24081329}.
Interaction partners:
- Uncharacterized RNA-binding protein C660.15
- Nuclear cap-binding protein subunit 2
- mRNA export factor mex67
- Importin subunit beta-2
- ATP-dependent RNA helicase uap56
- Polyadenylate-binding protein, cytoplasmic and nuclear
- mRNA export protein mlo3
- Polyadenylate-binding protein 2
- mRNA export factor gle1
- Poly
Sequence:
MTTLLETPGYSEKLHDSIEKKLSEYGWGEEAASLADFVLVMLSNGKTQTEINEELVDLIGSDFDTSFSLWLFNQIEELEKSKNASVESVSKIDEIDFIEKESTDKSQQSFSVPETSIQPQSSQTPNITSLREEKELPTGRVGQKLKLTSQKQRFNPMAASFNYSKSVMPAAKRALTQTQEVPLCKYADKCSRANCIFAHPTPAAAPGEGMVLSSEMCASGKECKAADCVKGHPSPATVTTLPPFMSMSTIPIPCKYKPCLNPACRFIHPTKSRNMTWRPPSKTEETSLSERSFAVNESEEQLHVPSV
Protein: Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Protein C10) (P26452)
Organism: Bos taurus (Bovine)
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:1849001}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). {ECO:0000255|HAMAP-Rule:MF_03016}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL10
- 60S ribosomal protein L18.
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL24
- Small ribosomal subunit protein eS10
Sequence:
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPSTEDWSAAPTAQATEWVGTTTEWS
Protein: Transposon Ty2-DR1 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) (Transposon Ty917 protein A) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)] (Q12472)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLSQNSPNLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDLKNQHSEIPQAKTKVGNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYQRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTHTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQDKQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEKNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSINPLQLDKEPVQKVRAPKEVDADISEYNILPSTIRSRTPHIINKESTEMGGTIESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAACDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTNKSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNEDNKEKDRYIEAYHKEINQLLRMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGEGDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: CHK kinase-like domain-containing protein (Q8IMS4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAWLTAEYLEAALRRYYQNNELRVESMVINPALGKGENYGAILTRIHLVYSSIVEEHLIAKTVLEYEDAETKMKKAPYDIYNRELEIYEQVLPKLQELAGEQLCPKILHIDRQRGALIMEDLSYKGFVMAPRLQRLDEQHVSLVLRKLAKMQAASAVLENNLLENNFSLTEYDKGFFNRYTESFSAYFLGCLKSCANYLKTQAGYEHHAKLLDELAPYYMGLGLRCFKQEQTHINVLTHGDLWTNNMMFKYEAGVPSDVLLIDFQYAFWGSPTLDIHHLLNTSAVEQVRSELQMKMRGVYHDVFVGELQRLGFKGQRLPSRKQFHLESEQKRFYAVHCGLLLLPVLLNTDETDADFAALLSDQPRGMDMKRRLYLNPGIQDSIKQMVKHFELEGLLDPWQYEGL
Protein: Transcription factor elt-1 (P28515)
Organism: Caenorhabditis elegans
Function: Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses expression of eff-1 to prevent fusion of seam cells with the hypodermal syncytium. Involved in regulating expression of elt-3, a probable downstream target in hypodermal development pathways, in dorsal and ventral hypodermal cells. During postembryonic development, has a role in sperm development. Specifically, binds the bipartite consensus sequence 5'-AGATCTx(8)GATAA-3' found in genes with sperm-specific expression. Furthermore, regulates timing of developmental steps, possibly in parallel with daf-12, by controlling the expression of the let-7 family of miRNAs which in turn determines the transcription of heterochronic genes such as lin-41.
Subcellular location: Nucleus {ECO:0000269|PubMed:9224715}. Perikaryon {ECO:0000269|PubMed:16303852}. Cell projection, axon {ECO:0000269|PubMed:16303852}. Note=Expressed in pachytene nuclei during the first stage of meiosis. {ECO:0000269|PubMed:19591818}.
Interaction partners:
- Runt-related transcription factor rnt-1
- GATA-type domain-containing protein
- Transcription factor lin-26
- Nuclear hormone receptor family member nhr-25
- Defective pharyngeal development protein 4
- GATA-type domain-containing protein
- Serum response factor homolog
- GATA-type domain-containing protein
- T-box transcription factor tbx-8
- Transcription factor elt-6
Sequence:
MDYEGKPVEFTLGTSSGGASLAPTSSTTAASIAPFSYNTSATNYYNTTPSSYPMFLNYQYAGGTTVTTDMDAFSGMDMSMNNGVFGTQNNPSYFYPTTQLNTYGYDTLAAATTASGITVNNNQLNVNIVQGNGTIVPQPITQNIISTVSNVQSSVPINNSQPLTPTGLAGCSTSSGSSSASSSSANSTSTPKNTISKANRSSGGANNSQFSTEDRECVNCGVHNTPLWRRDGSGNYLCNACGLYFKMNHHARPLVKPKKRQQNAQKRTGIECVNCRTNTTTLWRRNGEGHPVCNACGLYFKLHKVERPITMKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN
Protein: GM05229p (Q95S93)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGDVQPRKRKDKRRKRDDDESSHGVHITKMGNEDLHLHVHHDHGTGGHWCAKIIFFALMAVLLGLVGLIIMENRGLEDLDTPLSESRFSKVFDGWVDEHRDEHDGHDVQEPSGEALDDHDEHDDHDDHEDEDEEPLTEELEEELEEEEEPTEEDEPAADEEYEEDEDEENNAGENITAEDAVEEEEEEDNDDEGTVEATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEEDDDEDEEEQEIEESVEPARSQYAAQSAPATDNNDDDDDDDDQDKNDADDGDDDEFESLDQQFENDPEDTEPAKAVESEEQDQDQADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIATAEDHIPDDVEELPPLDDEYSEEEIEIEEEIEVEISDIEEEEEEVRHDNDDNVASMASYVPETFEQLSAMYKYAQEPTKDAKPEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVSDEEITDEEDEISDVDDADLMNRLEAKYGRLPVKEFESDPDSDDPSWTRNY
Protein: Poly(A) RNA polymerase GLD2 (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Q5U315)
Organism: Rattus norvegicus (Rat)
Function: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q91YI6}. Nucleus {ECO:0000250|UniProtKB:Q91YI6}.
Interaction partners:
- Symplekin
- Cytoplasmic polyadenylation element-binding protein 1
- Poly
- polynucleotide adenylyltransferase
- Poly
- Neuroguidin
- 5'-3' exoribonuclease
Sequence:
MFPNSILGRPPFTPTHQQHNNFFALSPTLYSHQQLIDAQFNFQNVDLSRAVSLQPLTYGTVSPIQTSTSPLFRGRKRISDEKAFRLDGKRQRFHSPHQEPTIINQLVPLSGDRRYSMPPLFHTHYVPEIVRCVPPLREIPLLEPREITLPEAKDKLSQQILELFETCQQQASDLKKKELCRAQLQREIQLLFPQSRLFLVGSSLNGFGARSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNTVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHEINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSTSVQLHLVHHAPCNVPPYLSKNESSLGDLLLGFLKYYATEFDWNTQMISVREAKAIPRPDDMEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWQRLKNKRDLNSVLPLRAATLKR
Protein: B box-type domain-containing protein (H0Y626)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRVLLRFRRPSLGTGFCLVSLSDLLPGFPPSLQPLPPFQGPPLQPQMKDGRKGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRLFSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKLELNNQSKCLAHSQGSTALPCTSARSL
Protein: Syntaxin 5 (Q388I2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
- Golgi SNARE protein-like
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Sec1 family transport protein, putative
- Vesicle-associated membrane protein, putative
- SNARE protein, putative
- Vesicle tethering protein Uso1/P115-like head domain-containing protein
- t-SNARE coiled-coil homology domain-containing protein
- Golgi vesicular membrane trafficking protein, putative
- Longin domain-containing protein
- Synaptobrevin-type vesicle transport protein, putative
Sequence:
MVVERDRSNELHSIFNGMKHGEVLLHNGVRHIDPSRGELLQSNSGLRSSNETQIFNRFAQAFAADLAKVSESIMRLTQLTQRQTVFEDRSSEVTALTQVVKTSLQRLHADLNTLDELKARALDAEKVVLARTRASSGSEAHSLWGGRADVDSLVQSQTKHSDTIVETLRTRLARTGQTFRSTLQQQTKEMKSNAQRRHMFTTGDRPQTFESALFHDQEMQQQQQMQLASRGENVQYYKQRSEAVREIEAAVVEVGEMFNDFTRLVHEQNEIVLRIDTNVETSLRHVNAGSNELLRYLANLTSNRGLIIKIFAVLFFFLLFFGFLVVR
Protein: Ran GTPase-activating protein 1 (Protein involved in RNA production/processing) (P11745)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase activator for the nuclear Ras-related regulatory protein GSP1 (Ran), converting it to the putatively inactive GDP-bound state.
Subcellular location: Cytoplasm.
Interaction partners:
- GTP-binding nuclear protein GSP1/CNR1
- Ran-specific GTPase-activating protein 1
- Guanine nucleotide exchange factor SRM1
- SUMO-conjugating enzyme UBC9
- Ubiquitin-like protein SMT3
- GTP-binding nuclear protein GSP2/CNR2
- Nucleoporin NUP2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2
- U4/U6 small nuclear ribonucleoprotein PRP4
- Ubiquitin-like-specific protease 1
Sequence:
MATLHFVPQHEEEQVYSISGKALKLTTSDDIKPYLEELAALKTCTKLDLSGNTIGTEASEALAKCIAENTQVRESLVEVNFADLYTSRLVDEVVDSLKFLLPVLLKCPHLEIVNLSDNAFGLRTIELLEDYIAHAVNIKHLILSNNGMGPFAGERIGKALFHLAQNKKAASKPFLETFICGRNRLENGSAVYLALGLKSHSEGLKVVKLYQNGIRPKGVATLIHYGLQYLKNLEILDLQDNTFTKHASLILAKALPTWKDSLFELNLNDCLLKTAGSDEVFKVFTEVKFPNLHVLKFEYNEMAQETIEVSFLPAMEKGNLPELEKLEINGNRLDEDSDALDLLQSKFDDLEVDDFEEVDSEDEEGEDEEDEDEDEKLEEIETERLEKELLEVQVDDLAERLAETEIK
Protein: NADH-cytochrome b5 reductase-like protein (B5R) (EC 1.6.2.2) (P83291)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Desaturation and elongation of fatty acids.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:21896887}.
Interaction partners:
- Cytochrome b5 isoform B
- Cytochrome b5 isoform A
- Cytochrome b5 isoform E
- Cytochrome B5 isoform D
- Cytochrome B5 isoform C
- Dihydroorotate dehydrogenase
- Dihydropyrimidine dehydrogenase
- NADH--cytochrome b5 reductase 1
- Uridine 5'-monophosphate synthase
- Cytochrome B5-like protein
Sequence:
MATSFFRRLARSAPITFPVAFGSQSKSGSGAFRFSTGAIAALSGGFSYYYLTSGNNLVYLDQAKEETGPKTALNPDKWLEFKLQDTARVSHNTQLFRFSFDPSAELGLHVASCLLTRAPLGYNAEGKTKYVIRPYTPISDPEAKGYFDLLIKVYPDGKMSQHFASLKPGDVLEVKGPVEKFKYSPNMKKHIGMIAGGSGITPMLQVIDAIVKNPEDNTQISLLYANVSPDDILLKQKLDVLQANHPNLKIFYTVDNPTKNWKGGVGYISKDMALKGLPLPTDDTLILVCGPPGMMEHISGGKAPDWSQGEVKGILKELGYTEEMVFKF