wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor bHLH7 (Basic helix-loop-helix protein 7) (AtbHLH7) (bHLH 7) (Transcription factor EN 92) (bHLH transcription factor bHLH007) (Q93Y00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Bromodomain testis-specific protein
- Conserved oligomeric Golgi complex subunit 8
- SNF1-related protein kinase catalytic subunit alpha KIN12
- Mediator of RNA polymerase II transcription subunit 7b
- SPX domain-containing membrane protein At4g11810
- At1g20770
- SPX domain-containing membrane protein At4g22990
- SPX domain-containing membrane protein At1g63010
- SPX domain-containing protein 4
- Transmembrane protein
Sequence:
MANNNNIPHDSISDPSPTDDFFEQILGLSNFSGSSGSGLSGIGGVGPPPMMLQLGSGNEGNHNHMGAIGGGGPVGFHNQMFPLGLSLDQGKGHGFLKPDETGKRFQDDVLDNRCSSMKPIFHGQPMSQPAPPMPHQQSTIRPRVRARRGQATDPHSIAERLRRERIAERIRSLQELVPTVNKTDRAAMIDEIVDYVKFLRLQVKVLSMSRLGGAGAVAPLVTEMPLSSSVEDETQAVWEKWSNDGTERQVAKLMEENVGAAMQLLQSKALCIMPISLAMAIYHSQPPDTSSSIVKPEMNPPP
Protein: Telomeric repeat binding factor 2 (U3KQ35)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKYEDLLCRNFGAGWWSWLGLVLLP
Protein: Transmembrane BAX inhibitor motif containing 1 (C9JW19)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIIL
Protein: Putative transcription factor bHLH056 (Basic helix-loop-helix protein 56) (AtbHLH56) (bHLH 56) (Transcription factor EN 106) (bHLH transcription factor bHLH056) (Q9SVU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MQFDESDARVWIWFEIRREDDIVELLWQSGQVVGTNQTHRQSYDPPPILRGSGSGRGEENAPLSQPPPHLHQQNLFIQEGEMYSWLHHSYRQNYFCSELLNSTPATHPQSSISLAPRQTIATRRAENFMNFSWLRGNIFTGGRVDEAGPSFSVVRESMQVGSNTTPPSSSATESCVIPATEGTASRVSGTLAAHDLGRKGKAVAVEAAGTPSSGVCKAETEPVQIQPATESKLKAREETHGTEEARGSTSRKRSRTAEMHNLAERRRREKINEKMKTLQQLIPRCNKSTKVSTLDDAIEYVKSLQSQIQGMMSPMMNAGNTQQFMPHMAMDMNRPPPFIPFPGTSFPMPAQMAGVGPSYPAPRYPFPNIQTFDPSRVRLPSPQPNPVSNQPQFPAYMNPYSQFAGPHQLQQPPPPPFQGQTTSQLSSGQASSSKEPEDQENQPTA
Protein: Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4) (Q8WW27)
Organism: Homo sapiens (Human)
Function: Putative C to U editing enzyme whose physiological substrate is not yet known.
Interaction partners:
- C->U-editing enzyme APOBEC-1
- C->U-editing enzyme APOBEC-2
- DNA dC->dU-editing enzyme APOBEC-3H
- DNA dC->dU-editing enzyme APOBEC-3C
- DNA dC->dU-editing enzyme APOBEC-3A
- Single-stranded DNA cytosine deaminase
- DNA dC->dU-editing enzyme APOBEC-3B
- Cytidine deaminase
- DNA dC->dU-editing enzyme APOBEC-3D
- DNA dC->dU-editing enzyme APOBEC-3F
Sequence:
MEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVSLTEFCQIFGFPYGTTFPQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMNGYLDSAIYNNDSIRHIILYSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHTEMDFPASAWNREALRSLASLWPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGRALADRHNAYEINAITGVKPYFTDVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPSGQLQPNLPPDLRAPVVFVLVPLRDLPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLGRLPTGRSVEIVEITEQFASSKEADEKKKKKGKK
Protein: Palmitoyltransferase ZDHHC7 (EC 2.3.1.225) (Acyltransferase ZDHHC7) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 7) (DHHC-7) (Q9NXF8)
Organism: Homo sapiens (Human)
Function: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways. Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane. In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation. Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration. Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:22031296}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVAYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPTRPRKGGPEFSV
Protein: Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor) (Q6UWN8)
Organism: Homo sapiens (Human)
Function: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8BT20}.
Interaction partners:
- Kallikrein-14
- Kallikrein-13
- Kallikrein-5
- Kallikrein-12
- Kallikrein-4
Sequence:
MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC
Protein: Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase like 1) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1) (P28650)
Organism: Mus musculus (Mouse)
Function: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Partially associated with particulate fractions.
Interaction partners:
- Adenylosuccinate lyase
- Bifunctional purine biosynthesis protein ATIC
- Inosine-5'-monophosphate dehydrogenase 2
- Inosine-5'-monophosphate dehydrogenase 1
- Trifunctional purine biosynthetic protein adenosine-3
- GMP reductase 1
- AMP deaminase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- Multifunctional protein CAD
- Inosine triphosphate pyrophosphatase
Sequence:
MSGTRASNDRPPGTGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHMGVAVKWVGVGKSRESMIQLF
Protein: UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UXS-1) (Q6GMI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Essential during embryogenesis for craniofacial development.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q5PQX0}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8NBZ7}.
Interaction partners:
- UDP-glucose 6-dehydrogenase
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- Xylosyltransferase I.
- Exostosin glycosyltransferase 2
- Glycosaminoglycan xylosylkinase
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- Protein unc-50 homolog
- FAM20C golgi-associated secretory pathway kinase a
Sequence:
MMRMSWMVTVINRRMMKILIALALIAYIASVWGTYANMRSIQEHGEMKIEQRIDEAVGPLREKIRELELSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQNEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGSRMHMNDGRVVSNFILQALQGEALTVYGSGSQTRAFQYVSDLVNGLVSLMNSNISSPVNLGNPEEHTILEFAQLIKSLVASRSHIQFLPEAQDDPQRRRPDIRKAKLLLGWEPVVPLEEGLNKTIQYFSRELEHQANNQYIPKPKAARMKKGRPRHN
Protein: Antitermination protein Q (P03047)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes. Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP. To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation. Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes.
Interaction partners:
Sequence:
MRLESVAKFHSPKSPMMSDSPRATASDSLSGTDVMAAMGMAQSQAGFGMAAFCGKHELSQNDKQKAINYLMQFAHKVSGKYRGVAKLEGNTKAKVLQVLATFAYADYCRSAATPGARCRDCHGTGRAVDIAKTELWGRVVEKECGRCKGVGYSRMPASAAYRAVTMLIPNLTQPTWSRTVKPLYDALVVQCHKEESIADNILNAVTR
Protein: NUP-1 protein (Q387M9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIEADVIRLNMEVEAAAARNADLSREVARLREELANSGLHNMDRTLVITEGTQTDSGMLREVALDLDDILFEVSELLFRLYPASSLDLSVRRDAQSSQLNDLSQRCLREVRSLKAAWEMKLDGYNQFISNIQRSQVDYHRSLDSKECQLRRKQQECDVLVGENARLSTLCSELESQLKTTQEAATRAEEQVGRLLQQTADLEAERRRLLDREAAMANTLVALRAECAFNPWSSLVGVKEAATTIESNGQLPSVREQAVAVTKAHIKPPGAVSASDVAMAFQGLDLDGQLPHMCVEPESVVDYYCKVKHSSPTRSLM
Protein: Ferredoxin (P9WNE7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Interaction partners:
- Alpha-crystallin
- Putative NAD
- Uncharacterized protein Rv1738
- Probable diacyglycerol O-acyltransferase tgs1
- Universal stress protein Rv3134c
- Universal stress protein Rv2623
- Hypoxic response protein 1
- Universal stress protein Rv1996
- Dormancy associated translation inhibitor
- Uncharacterized protein Rv0080
Sequence:
MTYVIGSECVDVMDKSCVQECPVDCIYEGARMLYINPDECVDCGACKPACRVEAIYWEGDLPDDQHQHLGDNAAFFHQVLPGRVAPLGSPGGAAAVGPIGVDTPLVAAIPVECP
Protein: HTH-type transcriptional regulator XapR (Xanthosine operon regulatory protein) (P23841)
Organism: Escherichia coli (strain K12)
Function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine.
Interaction partners:
- Purine nucleoside phosphorylase 2
- Xanthosine permease
- Probable cyclic di-GMP phosphodiesterase PdeA
- Uncharacterized HTH-type transcriptional regulator YafC
- HTH-type transcriptional activator TtdR
- Uncharacterized HTH-type transcriptional regulator YeiE
- Uncharacterized HTH-type transcriptional regulator YneJ
- HTH-type transcriptional regulator YjiE
- Uncharacterized HTH-type transcriptional regulator YfiE
- HTH-type transcriptional regulator DsdC
Sequence:
MERVYRTDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELENQLGTQLFIRHSRSVVLTHAGKILMEESRRLLVNANNVLARIEQIGRGEAGRIELGVVGTAMWGRMRPVMRRFLRENPNVDVLFREKMPAMQMALLERRELDAGIWRMATEPPTGFTSLRLHESAFLVAMPEEHHLSSFSTVPLEALRDEYFVTMPPVYTDWDFLQRVCQQVGFSPVVIREVNEPQTVLAMVSMGIGITLIADSYAQMNWPGVIFRPLKQRIPADLYIVYETQQVTPAMVKLLAALTQ
Protein: Probable LRR receptor-like serine/threonine-protein kinase MEE39 (EC 2.7.11.1) (Protein MATERNAL EFFECT EMBRYO ARREST 39) (C0LGP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor-like serine/threonine-kinase required during the endosperm development in seeds.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Cysteine-rich repeat secretory protein 59
- Alpha-1,3/1,6-mannosyltransferase ALG2
- Cysteine-rich repeat secretory protein 29
- At5g55620
Sequence:
MKNLCWVFLSLFWFGVFLIIRFAEGQNQEGFISLDCGLPLNEPPYIESETGIQFSSDENFIQSGKTGRIPKNLESENLKQYATLRYFPDGIRNCYDLRVEEGRNYLIRATFFYGNFDGLNVSPEFDMHIGPNKWTTIDLQIVPDGTVKEIIHIPRSNSLQICLVKTGATIPMISALELRPLANDTYIAKSGSLKYYFRMYLSNATVLLRYPKDVYDRSWVPYIQPEWNQISTTSNVSNKNHYDPPQVALKMAATPTNLDAALTMVWRLENPDDQIYLYMHFSEIQVLKANDTREFDIILNGETINTRGVTPKYLEIMTWLTTNPRQCNGGICRMQLTKTQKSTLPPLLNAFEVYSVLQLPQSQTNEIEVVAIKNIRTTYGLSRISWQGDPCVPKQFLWDGLNCNITDISAPPRIISLNLSSSGLSGTIVSNFQNLAHLESLDLSNNSLSGIVPEFLATMKSLLVINLSGNKLSGAIPQALRDREREGLKLNVLGNKELCLSSTCIDKPKKKVAVKVVAPVASIAAIVVVILLFVFKKKMSSRNKPEPWIKTKKKRFTYSEVMEMTKNLQRPLGEGGFGVVYHGDLNGSEQVAVKLLSQTSAQGYKEFKAEVELLLRVHHINLVNLVGYCDEQDHFALIYEYMSNGDLHQHLSGKHGGSVLNWGTRLQIAIEAALGLEYLHTGCKPAMVHRDVKSTNILLDEEFKAKIADFGLSRSFQVGGDQSQVSTVVAGTLGYLDPEYYLTSELSEKSDVYSFGILLLEIITNQRVIDQTRENPNIAEWVTFVIKKGDTSQIVDPKLHGNYDTHSVWRALEVAMSCANPSSVKRPNMSQVIINLKECLASENTRISRNNQNMDSGHSSDQLNVTVTFDTDVKPKAR
Protein: Phosphodiesterase (EC 3.1.4.-) (Q8VIE2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenine phosphoribosyltransferase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Deoxycytidine kinase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Adenylosuccinate lyase
- Adenylate kinase 8
- Adenylate kinase 2, mitochondrial
- Adenylate cyclase type 5
Sequence:
MSCLMVERCGEVLFENPEQNVKCVCMLAASSPPPLPMAGQGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENIQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSESMLNHLAHNKAQWKSLLSNQHRRRGSGQDPAGTAPETLEQTEGATP
Protein: Mucin-6 (Ovomucin, beta-subunit) (F1NBL0)
Organism: Gallus gallus (Chicken)
Function: Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Uncharacterized protein.
- CTCK domain-containing protein.
- Uncharacterized protein.
- Uncharacterized protein.
- Uncharacterized protein.
- Polypeptide N-acetylgalactosaminyltransferase.
Sequence:
CSTWGGGHFSTFDKYQYDFTGTCNYIFATVCDESSPDFNIQFRRGLDKKIARIIIELGPSVIIVEKDSISVRSVGVIKLPYASNGIQIAPYGRSVRLVAKLMEMELVVMWNNEDYLMVLTEKKYMGKTCGMCGNYDGYELNDFVSEGKLLDTYKFAALQKMDDPSEICLSEEISIPAIPHKKYAVICSQLLNLVSPTCSVPKDGFVTRCQLDMQDCSEPGQKNCTCSTLSEYSRQCAMSHQVVFNWRTENFCSVGKCSANQIYEECGSPCIKTCSNPEYSCSSHCTYGCFCPEGTVLDDISKNRTCVHLEQCPCTLNGETYAPGDTMKAACRTCKCTMGQWNCKELPCPGRCSLEGGSFVTTFDSRSYRFHGVCTYILMKSSSLPHNGTLMAIYEKSGYSHSETSLSAIIYLSTKDKIVISQNELLTDDDELKRLPYKSGDITIFKQSSMFIQMHTEFGLELVVQTSPVFQAYVKVSAQFQGRTLGLCGNYNGDTTDDFMTSMDITEGTASLFVDSWRAGNCLPAMERETDPCALSQLNKISAETHCSILTKKGTVFETCHAVVNPTPFYKRCVYQACNYEETFPYICSALGSYARTCSSMGLILENWRNSMDNCTITCTGNQTFSYNTQACERTCLSLSNPTLECHPTDIPIEGCNCPKGMYLNHKNECVRKSHCPCYLEDRKYILPDQSTMTGGITCYCVNGRLSCTGKLQNPAESCKAPKKYISCSDSLENKYGATCAPTCQMLATGIECIPTKCESGCVCADGLYENLDGRCVPPEECPCEYGGLSYGKGEQIQTECEICTCRKGKWKCVQKSRCSSTCNLYGEGHITTFDGQRFVFDGNCEYILAMDGCNVNRPLSSFKIVTENVICGKSGVTCSRSISIYLGNLTIILRDETYSISGKNLQVKYNVKKNALHLMFDIIIPGKYNMTLIWNKHMNFFIKISRETQETICGLCGNYNGNMKDDFETRSKYVASNELEFVNSWKENPLCGDVYFVVDPCSKNPYRKAWAEKTCSIINSQVFSACHNKVNRMPYYEACVRDSCGCDIGGDCECMCDAIAVYAMACLDKGICIDWRTPEFCPVYCEYYNSHRKTGSGGAYSYGSSVNCTWHYRPCNCPNQYYKYVNIEGCYNCSHDEYFDYEKEKCMPCAMQPTSVTLPTATQPTSPSTSSASTVLTETTNPPV
Protein: Heat stress transcription factor B-1 (AtHsfB1) (AtHsf-16) (Heat shock factor protein 4) (HSF 4) (Heat shock transcription factor 4) (HSTF 4) (Q96320)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Heat shock 70 kDa protein 4
- Chaperone protein ClpB1
- Multiprotein-bridging factor 1c
- Dehydration-responsive element-binding protein 2A
- Heat shock protein 90-1
- Heat shock protein 90-3
- Peptidyl-prolyl cis-trans isomerase FKBP62
- 18.1 kDa class I heat shock protein
Sequence:
MTAVTAAQRSVPAPFLSKTYQLVDDHSTDDVVSWNEEGTAFVVWKTAEFAKDLLPQYFKHNNFSSFIRQLNTYGFRKTVPDKWEFANDYFRRGGEDLLTDIRRRKSVIASTAGKCVVVGSPSESNSGGGDDHGSSSTSSPGSSKNPGSVENMVADLSGENEKLKRENNNLSSELAAAKKQRDELVTFLTGHLKVRPEQIDKMIKGGKFKPVESDEESECEGCDGGGGAEEGVGEGLKLFGVWLKGERKKRDRDEKNYVVSGSRMTEIKNVDFHAPLWKSSKVCN
Protein: Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) (P13533)
Organism: Homo sapiens (Human)
Function: Muscle contraction.
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Interaction partners:
- Myosin-7
- Myosin light chain 3
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin-binding protein C, cardiac-type
- Actin, alpha cardiac muscle 1
- Alpha-actinin-2
- Myosin light chain 4
- Troponin I, slow skeletal muscle
- Troponin T, cardiac muscle
- Myosin light chain 1/3, skeletal muscle isoform
Sequence:
MTDAQMADFGAAAQYLRKSEKERLEAQTRPFDIRTECFVPDDKEEFVKAKILSREGGKVIAETENGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDEE
Protein: Nudix hydrolase 8 (AtNUDT8) (EC 3.6.1.-) (Q8L7W2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity). May be involved in plant immunity and act as a positive regulator of defense response through salicylic acid (SA) signaling.
Interaction partners:
- Nudix hydrolase 1
- FAD/NAD
- Nudix hydrolase 24, chloroplastic
- Nudix hydrolase 13, mitochondrial
- Nudix hydrolase 11
- Nudix hydrolase 15, mitochondrial
- Nudix hydrolase 4
- Chaperone DnaJ-domain superfamily protein
- Nudix hydrolase 25
- CAP superfamily protein
Sequence:
MDSVSLSEVTVIKGTTHLGFMHSFRQPFCGVKISPKFYLSKVDGPKAISSSSNTKSQFVYGGGSIAATSDSGYKMNGVNLKSRTLMSSAVKERSLLDAYDDEYGGVIVDHGKLPSNPYAFASMLRASLSDWRRKGKKGVWLKLPVEQSELVPIAIKEGFEYHHAEKGYVMLTYWIPEEEPSMLPANASHQVGVGGFVLNQHKEVLVVQEKYCAPSITGLWKLPTGFINESEEIFSGAVREVKEETGVDTEFSEVIAFRHAHNVAFEKSDLFFICMLRPLSDKIIIDALEIKAAKWMPLAEFVEQPMIRGDKMFKRVIEICEARLSHRYCGLSPHRLVSTFDGKPSSLYYNVVDDDHDPSHSNCSTEFYR
Protein: Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) (P15884)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22777675}.
Interaction partners:
- Catenin beta-1
- Transcription factor 12
- DNA-binding protein inhibitor ID-2
- Myoblast determination protein 1
- DNA-binding protein inhibitor ID-1
- T-cell acute lymphocytic leukemia protein 1
- Transducin-like enhancer protein 1
- B-cell CLL/lymphoma 9-like protein
- DNA-binding protein inhibitor ID-4
- Myogenin
Sequence:
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM
Protein: Protein yippee-like 5 (P62699)
Organism: Homo sapiens (Human)
Function: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for normal cell proliferation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q65Z55}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q65Z55}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q65Z55}. Midbody {ECO:0000250|UniProtKB:Q65Z55}. Note=Deteted in nucleus and at the centrosome during interphase. During mitosis, detected on the mitotic spindle, at spindle poles and at the midbody. {ECO:0000250|UniProtKB:Q65Z55}.
Interaction partners:
- Ran-binding protein 10
- Ran-binding protein 9
- E3 ubiquitin-protein transferase RMND5A
- WD repeat-containing protein 26
- Armadillo repeat-containing protein 8
- Glucose-induced degradation protein 8 homolog
- E3 ubiquitin-protein transferase MAEA
- E3 ubiquitin-protein transferase RMND5B
- Muskelin
Sequence:
MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS