wanglab/gogpt-training-data huggingface dataset:
Protein: C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)] (P13501)
Organism: Homo sapiens (Human)
Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Subcellular location: Secreted.
Interaction partners:
- C-C chemokine receptor type 1
- Platelet factor 4
- C-X-C chemokine receptor type 3
- C-C chemokine receptor type 2
- C-C chemokine receptor type 3
- C-X-C motif chemokine 9
- C-X-C motif chemokine 2
- C-X-C motif chemokine 10
- C-X-C motif chemokine 6
- C-C motif chemokine 2
Sequence:
MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS
Protein: Magnetosome protein MamQ (Q93DY8)
Organism: Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)
Function: Essential for magnetosome formation. Not essential for formation of magnetosome membrane vesicles. One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:14766587, ECO:0000269|PubMed:27286560}; Single-pass membrane protein {ECO:0000255}. Cell inner membrane {ECO:0000269|PubMed:27286560}; Single-pass membrane protein {ECO:0000255}. Note=Tagged protein is more abundant in cell inner membrane, is visible as puncate spots all throughout inner and magnetosome membranes. {ECO:0000269|PubMed:27286560}.
Interaction partners:
- Magnetosome protein MamB
- Probable membrane transporter protein MamO
- Magnetosome protein MamR
- Magnetosome protein MamT
- Multi-heme protein MamP
- Actin-like protein MamK
- Magnetosome protein MamM
- Magnetosome protein MamL
- Magnetosome formation protease MamE
- Magnetosome protein MamH
Sequence:
MAVSDADASSVDKVESITLQRVKQSEELLAQLYVVEESPRRMGRGPVQLMLAISVLSLVAFITTLLMRYNAFVTMYEDAQAKRSNFEVMIQRRDNLFGNLVKLTLNHAALEHSIFSHTSDKRKESVEAGKGGPIGSAIEQLMKQGGIGKLLGDGGAGKALLGADGGFGNALGRLMAIVEQYPTVQSADTYKHMMTSLVDMEDRIASKREEFNASAATYNVAITKWPWDYLAMITGFKRVEYFHEKPAGDTPIITPQIFQELLPLTHSQESKN
Protein: Uga32p (Q5ABD2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFYVFDLTSNETIATDTSQAHELQPTTTPSNQQHIKLRTILNTSKRSRTGCLQCRARKKKCNEEHPVCGSCKRRKVNCSWRVTSKFKILKNGHQENSTSSEEIQESNYTRVDNQSTNDDPPDQNILRGSDKALHQKSDNTDIISLDKNLSSISPKYLSEPGYDFSDLSFLEHCIPSPINSHIFQPFKYLNVQGLYFLDGFIANVAKKFSIGHESSNYILKTFYQLSEEHEAVSYALAAWGGIFIEGGFTENVNHFLGEAIFKMSQEYPNLNNISKKDVYILLNYYLVYIGLQVCAGDVSQWHQIFHRTIDLVKRQGGLSSIIEMFDCSNEIKWLLSDIQYHDILSSNTFQKGTMLPMEEYNSVFKEAKILELGNYGLDPFQGCIQPIYLVLGEITSSAVDLRLRQHEIEIDGDITSRLEFYHEADKCYRDLSYKISNCIPNIEQMKLIKDDRYELELHLTLFEVYSLTCQLCLNYLIKKLPANTLDMQLLVLNCLASIDILIDTKMKSALSFSLLVCGITCCSKNDRSSMLNRFKIVSDDYKAGNVTLIKSIVEKVWERNQNGQLCVDWLTICQENNWNISFC
Protein: Poliovirus receptor related immunoglobulin domain containing (A0A1B0GS01)
Organism: Mus musculus (Mouse)
Interaction partners:
- Nectin-2
Sequence:
MRTGNTQAAHATNMGQMQTLVLFSTLLTLCVSEASPEVWVQVQMEATNLSSFSVHCGVLGYSLISLVTVSCEGFVDAGRTKLAVLHPEFGTQQWAPARQAHWETPNSVSVTLTMGQSKARSSLANTTFCCEFVTFPHGSRVACRDLHRSDPGLSAPTPALNLQADLVRILGTSGVFLFGFIFILCLRWQQRHWCLSKSQPSLTSTQAQVETQPPHLASTHSSFISMENGLYALA
Protein: Interferon lambda receptor 1 (IFN-lambda R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (K9JA28)
Organism: Gallus gallus (Chicken)
Function: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Uncharacterized protein.
- Tyrosine-protein kinase
- Tyrosine-protein kinase.
- Interleukin-22 receptor subunit alpha-1
- Uncharacterized protein.
- Signal transducer and activator of transcription.
- Signal transducer and activator of transcription
- Interferon lambda-3
- Uncharacterized protein.
Sequence:
MSAWRIRVLATLCFLWQPRVHGQLPPPQNVTLLSKDFDMILTWTPGEGSPPDVLYTVRYESKTRMDKWIKVPHCRNIHSVSCNLTCVIPNFFIKFRAQVKATSGRFHSPWVKSQFKEYHLDVELAPPLLNVNVKENVIHVNATFPMAICVESLPWMYDFNLWEAGSEDKKQYKSIFRKKAVTIDTTALRGNYCFNARSSIQSIDFKHSKFSQPVCMQLNYEGEWKFPFSATIPVFVLLILLTSASIIWLLKQDAKHKKMPQTLDLSNCKIAGPTFCCELRENEFLTDCLICTDKPMSQGKKNKTLAQNNQMWMASFLPSSSSEEEEEEEEEDSSSFIPYTEMLQFPRKHFNFQTPRTADAETILDSTSGVLSVVGGSTLDLSALGFSFFPIRKNEMDTSGSQGNEKASHSHSSSLGRISLTDVRFPGPREHGQHGTDSNDCLEVSLLHTLMNSSCTRLPADEHCLYKKDHDFTICYQKPTLDQPVQVSENPLLNEDPSMEKFIYLQTLQVAEDEGFASDCDSGNFTEGTPPASTVLSDELRISDMEKRYDKKFKFKGYQHSHYMRRS
Protein: Metacaspase-1 (EC 3.4.22.-) [Cleaved into: Large subunit p20; Small subunit p10] (Q08601)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cysteine protease that cleaves specifically after arginine or lysine residues. Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pro-apoptotic serine protease NMA111
- Apoptosis-inducing factor 1
- Mitochondrial nuclease
- Bax inhibitor 1
- Cell division control protein 48
- Cytochrome c isoform 2
- Cytochrome c isoform 1
- Chromosomal passenger complex protein BIR1
- Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial
- Pheromone-processing carboxypeptidase KEX1
Sequence:
MYPGSGRYTYNNAGGNNGYQRPMAPPPNQQYGQQYGQQYEQQYGQQYGQQNDQQFSQQYAPPPGPPPMAYNRPVYPPPQFQQEQAKAQLSNGYNNPNVNASNMYGPPQNMSLPPPQTQTIQGTDQPYQYSQCTGRRKALIIGINYIGSKNQLRGCINDAHNIFNFLTNGYGYSSDDIVILTDDQNDLVRVPTRANMIRAMQWLVKDAQPNDSLFLHYSGHGGQTEDLDGDEEDGMDDVIYPVDFETQGPIIDDEMHDIMVKPLQQGVRLTALFDSCHSGTVLDLPYTYSTKGIIKEPNIWKDVGQDGLQAAISYATGNRAALIGSLGSIFKTVKGGMGNNVDRERVRQIKFSAADVVMLSGSKDNQTSADAVEDGQNTGAMSHAFIKVMTLQPQQSYLSLLQNMRKELAGKYSQKPQLSSSHPIDVNLQFIM
Protein: Fluconazole resistance protein 3 (Q8X229)
Organism: Candida albicans (Yeast)
Function: Transcription factor that confers fluconazole resistance in S.cerevisiae by activation of the PDR5 gene. Can also activate the transcription of S.cerevisiae genes involved in 4-nitroquinoline-N-oxide resistance.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MNFKTENSTTPNGDWSQSKAFTNSGSSFPVLNGTCELDQENLALSNSGQPESIFTQDSGLHGIDVAAPSDITDLNNQSGYQYNNNLAHDLYFTGSMEMPTTQHPYITNTNNHLSYSNSSEEFSPIGNNMSPDSTGGANSNNFTSGNKRKASNESFSPLSGHHYGTESGNNNNNNGTSRSSQSSSHKSRKKLLDEKDAALIARDDSELTEEELQMKRKAQNRAAQRAFRERKESKLKELEAKLLASEEERQKLLDELEQIKKQNISIATENEILKHNGMGNINNDVQIGNLSSYGRLQVDKFNFPKTQKDFIEHVLQGTNHQLKDENKDKVYNDNQGHKLLALGAVWDYLQIKAEEADLDFNSIDFNDVMEKLKGNEKCHGYGPAYPLELVNEAIESSLN
Protein: RSD-2 domain-containing protein (Q2EEN1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSDSQVIAIILFDNEETNSAICYSEQLESSIKVHLPVGSPAKAGQLILFTEYNYENDTYFPDPRPDAIEYRECEMTRIENGELLISAKAACSSIETHITYPQSVAFADTFGKVNVAAESMERGVTYRVELAINIIDSEANNVPLFKISDIGEKLTGEENEAFLRKLNDFEELQGTWEDWTPEEIAVELEPVAAAEEPADPEVEEAKIEENGVNDESLTQSESDSVFLPQIESSASSEETMSESNSAENSEKPKKTFGRMPQSLSESSSSTISSSKVGVDHSVIVLNVDNDECVGFETTQLKLMTICTAGVTVPLRPYGIFQFIAAGNNYGKTSIQTQSARVSECEGAVFSSDDVPKISANVIFSSNPKHKSYNKEVGVSDRYGFVEIPRITGDFEFGTVYSTQITMVQYGDPLKACFKAVAPLKRQFIDDLDHYLQVMGKYEDNIYQLSRKNGLGAKSISRLPNEPRNGSKHGSTKRFTTPHVTGLVVDMEKRGNYFGCVWTCFGDVVFKSTPTFSQNGGYPSVGDLVNIRVEILSPGTKDQKNLGASMTEKPASLSTTVIWRNNGFIVKAYLIMKPEKLIYSEDNNRFYEHDQLGIVVADSSIYGSDNEQSKVFEFERLRNPITLGFTTNLMNKCYWAARLPMIHREPSPPEPINKYNDENVYDDFQKGGPQSVNSYRSDRQYQEKPPMQYQSYHDPADTISIHSQDNHRPMETRSNAGTSVSSVDRKEVGVVMKKVDKNTQIVYLSGQKAAAIHHWNTHSQSTIVGNSYIFMYRPIEVHKATHYAPFEITQVVEILNTENHGRVDRSEFSSLFTFDLCNVDQRYVERLAFGEALVLRSNDVGHVVMASNVKTPLNPSMTAVEVCQTYKGKRESENLVGYCRLVYGKVPREIVDGHFSDQFVSAYYFELHEILATSNAYIVRNENLDRRNLRGNTIEEVRDDISIQKRIAHMNFGQNEQQQQQSSLSSRGPTRPYSPVGSYQSSHQNFDNRSAAHNGDGRSTSQSHHSAGGSMNHQNFYQPPVYQSSSSQQSYQPRYNGAPSGPLPPPSSQSSFNGAPAPPHYSEMSNDYNRMVRKLAELTDTAAQMIINNDIRQQIKNISPDLLDDLERNIDACQREKRHYYEKYGN
Protein: Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (E7ESI2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}.
Interaction partners:
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Protein: Retinol-binding protein 5 (Cellular retinol-binding protein III) (CRBP-III) (HRBPiso) (P82980)
Organism: Homo sapiens (Human)
Function: Intracellular transport of retinol.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MPPNLTGYYRFVSQKNMEDYLQALNISLAVRKIALLLKPDKEIEHQGNHMTVRTLSTFRNYTVQFDVGVEFEEDLRSVDGRKCQTIVTWEEEHLVCVQKGEVPNRGWRHWLEGEMLYLELTARDAVCEQVFRKVR
Protein: Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (P68220)
Organism: Ovis aries (Sheep)
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-23 subunit alpha
- Interleukin-12 subunit alpha
- Interleukin-12 receptor subunit beta-1
- Interleukin-23 receptor
- Interleukin-12 receptor subunit beta-2
- Interleukin-2 receptor subunit alpha
- Protein disulfide-isomerase
- Interferon gamma receptor 1
- Interleukin-27 receptor subunit alpha
- Interleukin-6 receptor subunit beta
Sequence:
MHPQQLVVSWFSLVLLASPIVAIWELEKNVYVVELDWYPNAPGETVVLTCDTPEEDGITWTSDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSRSLLLLHKKEDGIWSTDILKDQKEPKAKSFLKCEAKDYSGHFTCSWLTAISTNLKFSVKSSRGSSDPRGVTCGAASLSAEKVSMDHREYNKYTVECQEGSACPAAEESLPIEVVMEAVHKLKYENYTSSFFIRDIIKPDPPKNLQLRPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKNKREKKLFTDQTSAKVTCHKDANIRVQARDRYYSSFWSEWASVSCS
Protein: Protein Wnt-5b (P22726)
Organism: Mus musculus (Mouse)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Tyrosine-protein kinase RYK
- Frizzled-3
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-4
- Frizzled-2
- Frizzled-6
- Wnt inhibitory factor 1
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-9
- Protein Wnt-5a
Sequence:
MPSLLLVVVAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRALMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELANSRFNQPTPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDRFKSVQVERCHCRFHWCCFVRCKKCTEVVDQYVCK
Protein: Dpr-interacting protein beta, isoform G (X2JCW3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMNLLVVKESGERIADISCSQEHTTKFSPKLSQVAKHRKLAQLEIASGSGLVGLGTGTGTGSGCGPAIRWQLLLLLLLGNCIVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKDRAPDQHPASGSDQLLGRGTMRLIGTFLLALLVLFTALAEAGPTTLSCRTKGGRQKKAKETSWNGRRARDGREDGHAAEWRQCWERSALSWRRSAPPELDYYSLIQL
Protein: Large ribosomal subunit protein eL43A (60S ribosomal protein L43-A) (L37a) (YL35) (P0CX25)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL2A
- Ribosome biogenesis protein NOP53
- Small ribosomal subunit protein eS21B
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein eL34B
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein uS19
Sequence:
MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA
Protein: Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (Amino acid starvation-induced protein) (ASI) (L23) (P24049)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P18621}.
Interaction partners:
- Large ribosomal subunit protein eL18
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein uL30
Sequence:
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE
Protein: Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3) (Q9P021)
Organism: Homo sapiens (Human)
Function: Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.
Subcellular location: Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with DLG4 in asymmetric synapses. {ECO:0000250}.
Interaction partners:
- Disks large homolog 4
- Armadillo repeat-containing protein 7
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 1
- Splicing factor 3B subunit 3
- E3 ubiquitin-protein ligase RNF113A
- Pre-mRNA-processing-splicing factor 8
- Splicing factor 3B subunit 2
- RNA-binding protein 48
- Sodium channel modifier 1
Sequence:
MVCEKCEKKLGTVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV
Protein: F-box protein 2 (G3V774)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- S-phase kinase-associated protein 1
- Beta-transducin repeat containing E3 ubiquitin protein ligase
- F-box only protein 4
- Cullin-1
- F-box/WD repeat-containing protein 7
- S-phase kinase-associated protein 2
- F-box only protein 6
Sequence:
MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQPREEEEEETEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADDERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSEHEDVLAEFNTGQVAVPEDGSWMEISHTFTDYGPGVRYVRFEHGGQDSVYWKGWFGARVTNSSVWVEP
Protein: Uncharacterized protein Rv1588c (P9WLT9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved 13E12 repeat family protein
- Uncharacterized protein Rv2100
- HicA-like toxin
- Partial REP13E12 repeat protein
- Probable PhiRv1 integrase
- Possible phage PhiRv1 protein
- Uncharacterized protein Rv3466
- Conserved 13E12 repeat family protein
Sequence:
MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL
Protein: Delta-6 fatty acyl desaturase (Q6QDP0)
Organism: Scophthalmus maximus (Turbot) (Psetta maxima)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQLTEQGETGSKRAGCVYTWEEVQSHSSRTDQWLVIDRKVYNTTQWAKRHPGGFHVISHYAGQDATEAFTAFHPDLKFVQKFLKPLLIGELAATEPSQDRNKNAALVQDFHTLRVKAESKGLFQARPLFFCLHLGHIVLLEALAWLIIWVWGTNWILTFLCALLMTIAQSQAGWLQHDFGHLSVFKQSRWNHLLQKFAIGHLKGASANWWNHRHFQHHAKTNIFRKDPDVNMLNIFVIGATQPVEYGVKKIKHMPYHRQHQYFFLVGPPLLIPVYFQMQLMNSIISRHDWVDLGWSMSYYLRFFCCYIPMYGLFGSVALIIFVRFLESHWFVWVTQMNHLPMDIDHEKHKDWLTMQLQATCNIEQSFFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPQVRALCAKYGITYQVKTMWQGLADVFRSLKTSGELWRDAYLHK
Protein: Fasciclin-like arabinogalactan protein 14 (A9XTL9)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MGSSIYGVSSSHISLFLFFSFLSLSTAALPQNPSGKSSPSGQINSNSVLVALLDSHYTELAELVEKALLLQTLEEAVGKHNITIFAPRNEALERQLDPEFKRFLLEPGNLKSLQSLLMFHIIPKRVGSHQWPDPKTGPVKHNTLCNDHIRLTSQSTGKKTVDSAELVRPDDVIRPDGVIHGIQQLLIPRSVIEDFNRRRNLRSITAVLPEGAPEVDPRTHRLKNPAPIPVGAPPVLPIYDAMAPGPSLAPAPAPGPGGPRHHFDGESQVKDFIQTLLHYGGYNEMADILVNLTSLATEMGRLVSEGYVITVLAPNDEAMAKLTTDQLSEPGAPEQIIYYHIIPEYQTEESMYNAVRRFGKVKYDTLRLPRKVVAQEADGSVKFGHGEGSAYLFDPDIYTDGRISVQGIDGVLFPEEETQTVKKPAAVKVVSKPRRGKLLEVGCWMLGSLGGGSGFRWCQ
Protein: Alpha-endosulfine (Q7ZXH9)
Organism: Xenopus laevis (African clawed frog)
Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MSDKYIGDSHLEETGEEKQDSQEKEAVTPEKAEEQKLKAKYPNLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKIKNKQLPCAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGHVEDLHHV
Protein: Interleukin enhancer-binding factor 3 (Q9JIL3)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q12906}. Cytoplasm {ECO:0000250|UniProtKB:Q12906}. Nucleus {ECO:0000250|UniProtKB:Q12906}. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:Q12906}.
Interaction partners:
- Interleukin enhancer-binding factor 2
- ATP-dependent RNA helicase A
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein M
- Interferon-induced, double-stranded RNA-activated protein kinase
- Heterogeneous nuclear ribonucleoprotein Q
- ELAV-like protein 1
- Heterogeneous nuclear ribonucleoprotein Q
- Heterogeneous nuclear ribonucleoprotein D0
- RNA-binding protein FUS
Sequence:
MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNSATAGYSQFYSNGGHYGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSGGSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR