Protein: Nipped-B-like protein scc-2 (Prion-like-(Q/N-rich) domain-bearing protein 85) (SCC2 homolog) (Q95XZ5)
Organism: Caenorhabditis elegans
Function: Plays an important role in the loading of the cohesin complex on to meiotic chromosomes. Forms a heterodimeric complex (also known as cohesin loading complex) with mau-2/SCC4 which mediates the loading of the cohesin complex onto chromatin (By similarity). Plays an essential role in cell division during embryonic development. Promotes normal chromosome organization during meiosis. Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during meiosis. Required for chromosome segregation during mitosis and meiosis. Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites.
Subcellular location: Nucleus {ECO:0000269|PubMed:21856158}. Chromosome {ECO:0000269|PubMed:21856158}. Note=Localizes to pachytene nuclei in germlines (PubMed:21856158). Localizes to the axial element of meiotic chromosomes in germlines (PubMed:21856158). {ECO:0000269|PubMed:21856158}.
Interaction partners:
- Structural maintenance of chromosomes protein 3
- Maternal uncoordinated protein 2
- Cohesin subunit scc-3
- Cnd1 domain-containing protein
- Rad21_Rec8 domain-containing protein
- Structural maintenance of chromosomes protein 1
- Sister chromatid cohesion protein 1
- Protein pid-4
- Structural maintenance of chromosomes-like protein 1
- Wings apart-like protein homolog 1
Sequence:
MDPNNLQNSLNGTGNPNFQPVQTNAGGFGHQMAQTGAAAAAAATGQYNPMLLQQQYLNFGFGMNYNNQLFDFQAQQQQQQQYLMQQQQQQQQLHHQQQQQHQNIAQPQAQHHQMNMFTQHQMLQLMQQQQQQQQQQPVQQIQRQQPIAQPIPQHTIPPSTSNQFQQQIQSAASSIFDSSVISSHQKLYEEQCRQIEKERKEQEERKRKQELEEQRKRNEELKRLRIAEEKRLLEEQQRLREQMERERLAEIKRLEEAARLEDERRIAADIEAQKQAMLQKMQAEQNKHIAEVERQRSELEERFARVSQPMTLVGTHFLPNFLDMIPFPYESMVDSTLPQVFDMERDSAILESCDPQMVATISNILNATNIDDIITRMDKLRPDDKETNDLFLDKLPPIIQAVVNYNTSALDVDSHNDMELLENEDVMMTEDITRTTAPSTSSSSYNNHHQNSIVMMTSSSVSMSEATQSSSVTMNHHDVDEEGPAPISIEKRRQMMSVGKAPKAGGGGGQNQRKKRDMVENLYDSLTDNFVPTDTGRRGRRRGRGSDDDEDELLQRDLKLIEEMEKGVKLPASVTGFTTTEEDVQHFFGSQKKRRKEDRIRKDRSPTPEDVIESRDAEWQERLRLKMEREKSRKADEESQNAWSLQALADNETFTRFCQTVDGVLEQGDSLDTELKMPKNKKRRSGGDHHHKGDENSDESDEEEEMDEIDPDLRIELYILEELRRGSARLRENHALQAVGADKLLKLVAMLDRNIRDAISADNQRLLVPCDDDVDVGDVLEKEICEERVKRASDAAVVALNIMSSHRMHKQVIIEDVIDRCVGLTRLLLIHLIYPASDSIYKSVNSKKKDRAPEEARRRKKAGVCTRDKFSEYIYERITEAIGLLAVLVKSESMTDTSVHNVASVALTPFFVANVGSLQITAMLLASNIFSRAEDSLRFSMITDLLSSLHRAPQFTQKNSNNGYSLPDGSWISTTTALFIQLVQSTIKIPKFKKHADEDELAKRSKKEEAMVKEGFLKASKVTNAFLNGFLAKCSQKGNKMDGEEDYRILFSNFLQELLSALYSPEWPAAEMILTALGSLLVKNFRSKSSDMTIRQASLDYLGNITAKLRKDQKEAIAGERRLDAVVKKSFLLLSDKGVEDYESVDISNLKQNDKLKVLETSLIDYLVITNSSDIIVYACNFYVGEWYKEVAEDLESARSKLKQTVDTNESEKDVKKAERKYEKIQYRGAEMKVFLSKILDKKEIKRRLEKSNKVKMLDSDAFWAVKFLAQSREFTHSFDTYLKHIVFGAGSETIVALRSKALKCLSSIIEADSSVLILEDVQQAVHTRMVDSHAQVRESAVELIGRFVLYDEEYVRKYYSQIAERILDTGVAVRKRVIRIMREICEKFPTFEMIPDMLARMIRRVTDEEGVKKLVFETFTTLWFQPVDTRIYTNAVATKVTTMCSVAQHCIKDAMSDYLEQLILHIVKNGQEGSGMSVAVKQIIDSLVDHILNLEQHKSSENVSEVELMRRKEQEEKYMAYLSTLAVFSKIRPLLLTSHVEVLLPYLTFSGAKTNAENQVTKEMIGMLERVIPLVPFPSNIVLDSIDENLCKVIMFNGMALVVSAVSCVASIYKKFKRGATKTIDVFSTYLKHLEVIKRNFDSNPRYDLDPKLFPILSRSIFTLGVLSRYFQFEEFVKEDPTEEKVEALKEKVFITLEFFSRYHKGGLRQKALTAMGHFCAQHSTYLTKRQLTNTYLEILNAANSPQQQQQRILVLQNLEMFLQCEEQKLAASHDKWDENKEAQNLKEMELSGSGLGSSVIQKYWKAVLESYVDADIQLRRAAVQVVWLTLNQGLVTPGASIPTLIAMTTDPVDVIRNRIDILLKEIDSKYSGMVQSKAMQGVRLSYKLHLKLRMLQQEKFVRGFRFCDFHLNTLPNALPEKTHDGMAVLSGLYQSLRTNRQQRRSFLQSMVKLFSEEFSHDKPQLMEYIFIADNLAMFPYQMIDEPLYVMRQIDQNIAQTGQSLLVQYKLQLRMQESEDEDIVFLDENMMSRLSQLGQIETFHQLFLDSQVPSLLLYVRTFLMQLYGFNETKVAEYQPSEAAKVYEKAVTRRNIHMFKPITALEALNFPFEWGSFQHTAFLAEKICSFRKMLLSLDQVEEVEVSNTITAANDDYDEEEDGGEDSRGPIMEQMEH