wanglab/gogpt-training-data huggingface dataset:
Protein: ADP-ribosylation factor-like protein 6 (Q0IIM2)
Organism: Bos taurus (Bovine)
Function: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization (By similarity).
Subcellular location: Cell projection, cilium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane (By similarity). {ECO:0000250}.
Interaction partners:
- Bardet-Biedl syndrome 7 protein homolog
- Bardet-Biedl syndrome 1
- Tetratricopeptide repeat domain 8
- Bardet-Biedl syndrome 5 protein homolog
- Bardet-Biedl syndrome 2 protein homolog
- Bardet-Biedl syndrome 9
- BBSome complex member BBS4
- BBSome interacting protein 1
- Leucine zipper transcription factor-like protein 1
- WD repeat containing planar cell polarity effector
Sequence:
MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQDIVPTIGFSIQKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDKLRMVVAKEELRTLLNHPDIKHRRIPILFFANKMDLRDALTSVKVSQLLCLEDIKDKPWHICASDAIKGEGLQEGVDWLQDQIQSVKT
Protein: Serine/arginine-rich SC35-like splicing factor SCL30A (At-SCL30A) (AtSCL30A) (SC35-like splicing factor 30A) (Serine/arginine-rich splicing factor 30A) (Q9LHP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in intron recognition and spliceosome assembly. Binds probably to multiple 5'-GAAG-3' repeats found in its third intron, suggesting autoregulation of alternative splicing. May be necessary for accurate splicing of the 3' region of introns.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:15133128}.
Interaction partners:
- Serine/arginine-rich splicing factor RS31
- Serine/arginine-rich splicing factor SR30
- Serine/arginine-rich splicing factor RSZ21
- Serine/arginine-rich splicing factor SC35
- Serine/arginine-rich splicing factor RS2Z33
- Serine/arginine-rich-splicing factor SR34
- Serine/arginine-rich SC35-like splicing factor SCL30
- Serine/arginine-rich SC35-like splicing factor SCL28
- Serine/arginine-rich SC35-like splicing factor SCL33
- Serine/arginine-rich splicing factor RSZ22
Sequence:
MRGRSYTPSPPRGYGRRGRSPSPRGRFGGSRDSDLPTSLLVRNLRHDCRQEDLRRPFEQFGPVKDIYLPRDYYTGDPRGFGFIQFMDPADAAEAKHQMDGYLLLGRELTVVFAEENRKKPTEMRTRDRGGRSNRFQDRRRSPPRYSRSPPPRRGRRSRSRSRGYNSPPAKRHQSRSVSPQDRRYEKERSYSRSPPHNGSRVRSGSPGRVKSHSRSPRRSVSPRKNRSYTPEQARSQSPVPRQSRSPTPVPRGAQNGDRSPSQ
Protein: Probable mannosyltransferase KTR4 (EC 2.4.1.-) (P38131)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRFLSKRILKPVLSVIILISIAVTVVLYFLTANENYLQAVKDSAKSQYASLRESYKSITGKTESADELPDHDAEVLDSIMDRLHEPLYEKDTFDPNEVLAENKQLYEEFLLQEISEPKVDNLVRSGDPLAGKAKGTILSLVRNSDLEDIISSIQQLEEEYNKNFGYPYTFLNDEEFTDEFKDGIKSILPKDRVVEFGTIGPDNWNMPDSIDRERYDQEMDKMSKENIQYAEVESYHNMCRFYSKEFYHHPLLSKYKYVWRLEPNVNFYCKINYDVFQFMNKNDKIYGFVLNLYDSPQTIETLWTSTMDFVEEHPNYLNVNGAFAWLKDNSQNPKNYDYTQGYSTCHFWTNFEIVDLDFLRSEPYEKYMQYLEEKGGFYYERWGDAPVRSLALALFADKSSIHWFRDIGYHHTPYTNCPTCPADSDRCNGNCVPGKFTPWSDLDNQNCQATWIRHSMSEEELEMY
Protein: GTPase cRac1A (Q6LC82)
Organism: Gallus gallus (Chicken)
Interaction partners:
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- TIAM Rac1 associated GEF 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Cytoplasmic FMR1-interacting protein
- BAR/IMD domain-containing adapter protein 2
- Dedicator of cytokinesis 1
- Uncharacterized protein.
- Rho guanine nucleotide exchange factor 6
- Serine/threonine-protein kinase PAK 3
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
Protein: Autophagy-related protein 11 C-terminal domain-containing protein (Q22342)
Organism: Caenorhabditis elegans
Interaction partners:
- Autophagy-related protein 13 homolog
- Serine/threonine-protein kinase unc-51
- Autophagy-related protein 101
- MRG domain-containing protein
- Beclin homolog
- Autophagic-related protein 16.1
- Autophagic-related protein 16.2
- ZZ-type domain-containing protein
- Ubiquitin-like protein atg-12
- Autophagy-related protein 5
Sequence:
MIMYHIFYMDRGQAMVFDLNAETTTFNVLQDMVSKEVGHRISDLTFLDESGTTPDGNKSLAEISTLGTETSPVYFFLKSGNERENHNGSDVTYIFQMIDDAVDQAQYVLKNQDPLKIYMELPERAKNCRKVCAETLQMCARLVQQHRFLHKGWLALINNLDISVSKMDKRGKKFKLVHSKSEELIEKSDTLLLNYSDVVEQLRRIEVPSEIFVKPASLMTSTSTPINPDEKCTLFDFIAMADPEASLDGLPDLVNEKIRQLKEQNAISVYTRLQSVHETSKNQEYRDFKGINKRFSQLEFSLKSCEERKNLVHKLVAQILETPKINDQNKLPPIIEEHRQCMLTIFENFSEFRNMVRVFDQSKQEILKNLRTRMSGFVVQNYDRLRVVLNDIVQYEYKSNAVRIHMDLIGQIRDAPILYSQSVSEIVRRRLLKTELEEWHTDHSTKCAQFSTDEEKSREQLGRKLKKHFLHALFPGLFDNLPEFYVKAPLEKYDTDLPNIAKEYIKDLRDALPELEPFLKVTLPNVASKLATKGSKQHPSFGQTRVESFLTDEPMRMARSHFNYSPAAWLSEDGGDSSPVPQPLMCRSPENALRESQCRSIPYVPSLQQLEGLDGPAPGSSAPISIPNSTSSRINFKQSGRQQSSQDLHHVGSAVSSDTSLLGHETPVKMEDTVLMTENKSELNLESNMNDSNDSIDSLLDVYEHIDYSAEDILLGLSDHTVQLEDAVKRLSKMQNIVANMTPRNEKLFKYLHQTAPRDFEIIIHDGDKLKNRVKELGESVESLETELENKKSTESNLEAKLAEMTVSHKKEIENTQAECIKRMSVEFELMTDSMSRQSKEQIESKDREIEELKAKLEKQNIAHEKALRNDPYSEEYKRTLTAEIRAELEKEFKQRIEVITKAVECKKDEAFARQEKTLEIENRVLSSENESKSKKLEAMNREKEQLESLIRQMPEGEVILDEFNALKESQPSAQIKDRFAAIRSRMERSTDGKCLDTNKVLLIDNILKVHKLQQLVNEREQYRDVIKSQPGGDQVLQFLENSTPTVPVDMEAYFNELTNFSGSFDEAGRKIAKIHEIAMETIWLQALVRANLGGPSLRDISADIHKESYQKDVETVTSIAMMDIFIDHDRDEIKKLTRTLQIWLNTNVSSLRSGGTYAIEDSPKIRECASKYKSMALKVSTYQGMEESFYQPMAASTIQVATSPSELEVERSSQNTICTQTRLCLPAMNLLVSVQDIKIGCAVIVIWHQAHNAYVIFCSSPNRYFVKESSIRRLGINTQNAATRRNWIIARVVRSDSCSIKKPVNRYNLPIGTIVRRVEVEAVNMDFEGDFNHISIA
Protein: Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] (O35314)
Organism: Rattus norvegicus (Rat)
Function: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Subcellular location: Secreted. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000250}.
Interaction partners:
- Chromogranin-A
- Secretogranin-2
- Secretogranin-3
- Neuroendocrine protein 7B2
- Pro-neuropeptide Y
- Neurosecretory protein VGF
Sequence:
MQRAMLLGLLGAAALAAVISAPVDNRDHNEEMVTRCIIEVLSNALSKSSAPTITPECRQVLRKSGKEVKGEEKGENENSKFEVRLLRDPSDASVGRWASSREETGAPVEDSPGQAKVDNEEWTGGGGHSREAVDDQESLHPSNQQVSKEAKIRHSEERGGKEEEEEEGKIYPKGEHRGDAGEEKKHTEESGEKHNAFSNKRSEASAKKKEESVARAEAHFVELEKTHSREQSSQESGEETRRQEKPQELPDQDQSEEESEEGEEGEEGATSEVTKRRPRHHHWRSQSNKPSYEGRRPLSEERKHAAGESKDANVATANLGEKRGHHLAHYRASEEEPDYGEELRSYPGFQAPQGLQYQGRGSEEVRAPSPRSEESQEKEYKRNHPDSELESTANRHSEETEEERSYEGAKGRQHRGRGREPGAYPALDSRQEKRLLDEGHDPVHESPVDTAKRYPQSKWQEQEKNYLNYDEEGDQGRWWQQEEQLEPEESREEVSFPDRQYAPYPTTEKRKRLGALFNPYFDPLQWKNSDFEKKGNPDDSFLDDDGEDGNGVTMTEKNFFPEYNYDWWEKRPFSEDVNWGYEKRSFARAPHLDLKRQYDDGVAELDQLLHYRKKAAEFPDFYDSEEQMGPHQEAEDEKDRADQRVLTEEEKKELENLAAMDLELQKIAEKFSQRG
Protein: Nitrogen regulatory protein areA (P17429)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression. Activates the transcription of uapA.
Subcellular location: Nucleus.
Interaction partners:
- Nitrogen metabolite repression protein nmrA
- Nitrite reductase [NAD
- Importin subunit alpha
- DNA-binding protein creA
- PTAB
Sequence:
MSGLTLGGGSGRVRPTQAAAAFPTSHDFADPDRSSVARNANRPSRRFAAPPQLSDDFSLESPTDSAQVHDNLLQDALFPEWKANSPRGVDSPDEMQKKDPLATQIWKLYSRTKAQLPNQERMENLTWRMMALSLRRQERERAQQQARASSQKSPVPGMSGIAQLRLSDRVSNTPTTTADTVSDAMNLDDFIIPFSPSDHPSPSTTKASEATTGAIPIKARRDQSASEATPVPASFPHPAQDQRRESEFGYVPRRVRKTSIDERQFFNLQIPSRKRPAESSPHVPPVSTSMLAHDPDFSHAVPEYTLDTSHGLSLQNQMNAQQLANAQNHTSPNMAFALDTFNLGDDPILPSAGPYQQQFTFSPSESPMTSGNPFANLYAQTPIASSLNSTDFFSPPPSGYQSTASTPQPAYDGEHSKYFDMPVDARSQRRVVPAYITQRSSNLSASLQPRYMYNQGGSSQDITQQNAHMGAQSSSMQSPGFSIPQHVDPTQVLNPNEFNGNHAAMFSFGADSDVEDDDGNQFSAGGLAMPAEFGDDSISDMNSNMAWETSYPNSFQSLPAFAAQHRKHVTIGSADMMDTPSEWNQGGSLGRTHESAASVSEVRNRDQDPRRQKIARTSSTPNTAQLLRQSMQNQSSHTSPNTPPESGLNSAAPSRPASPGGTKNGEQNGPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRNSANSLAVGSSRVSKKSARKNSVQQVTPTAPTSSRAQSNTTSESPPAMPGSSGRGSGVVPIAAAPPKSSSAATTSPGTNNGCGAVQVAPKRQRRLEKASDVDMAESPSSTSSGGRSKVVPLAPAMPPAAVNPANHSIAAGQGASQEWEWLTMSL
Protein: RecQ-mediated genome instability protein 1 (A0A0A0MSU3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNVTSIALRAETWLLAAWHVKVPPMWLEACINWIQEENNNVNLSQAQMNKQVFEQWLLTDLRDLEHPLLPDGILEIPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVTAEAQVTPKPWEAKPSRMLMLQLTDGIVQIQGMEYQPIPILHSDLPPGTKILIYGNISFRLGVLLLKPENVKVLGGEVDALLEEYAQEKVLARLIGEPDLVVSVIPNNSNENIPRVTDVLDPALGPSDEELLASLDENDELTANNDTSSERCFTTGSSSNTIPTRQSSFEPEFVISPRPKEEPSNLSIHVMDGELDDFSLEEALLLEETVQKEQMETKELQPLTFNRNADRSIERFSHNPNTTNNFSLTCKNGNNNWSEKNVSEQMTNEDKSFGCPSVRDQNRSIFSVHCNVPLAHDFT
Protein: Cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide III) (P00415)
Organism: Bos taurus (Bovine)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}; Multi-pass membrane protein {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- NADH-ubiquinone oxidoreductase chain 2
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b
- ATP synthase F
- Cytochrome c oxidase subunit 5B, mitochondrial
- NADH-ubiquinone oxidoreductase chain 5
Sequence:
MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
Protein: rRNA-processing protein cgr1 (Q9UTJ4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Ribosome production factor 2 homolog
- Ribosome biogenesis regulatory protein homolog
- Ribosome biogenesis protein nsa2
- Ribosome assembly protein 4
- Nucleolar GTP-binding protein 2
- Probable nucleolar GTP-binding protein 1
- Probable metalloprotease arx1
- Ribosome biogenesis protein rlp24
- Pescadillo homolog
- Ribosome biogenesis protein NOP53
Sequence:
MVNGTKGVCVSGKPWKTEKKAYNRSGLADAQRTPYEKRMEQKRKLDEIKEREKELKREKEEQRAAHAEKIRTRRQAKADRERMELLQAKLHQKVIDRRRRREKRNKMLKER
Protein: Glutathione S-transferase (Q22814)
Organism: Caenorhabditis elegans
Interaction partners:
- Glutathione S-transferase omega
Sequence:
MVHYKLTYFLSRGLGDVSRQLFHLADVDFEDERLEKPHFLEKKETYPFKQVPVLSVDGFQIPQSMAIARYLAKKFGFAGKTAEESAMVDAFVDQFKDFYSEIRDYYYTMLGLGLTDLDGDEQKDKVLIPARDKFLPLLTRYLEKSKSGFLVDGGLTFADLIILDNMTSLLNWWPEYANDYPVILAWRDKVMNYPRLKEYIEKRPVTMY
Protein: CHK kinase-like domain-containing protein (Q59DY2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTEPYSPVFTRENRTELFTLEECNKILANLLADKNEQGVLLNFNIVPATEHTGFLGEYFHLYFQYQLEDQKDVQTSRLFVKSVIFQNANMEFYMEKMGLIEKEIKLYDLLNELKKFSKHVWSAKCYFTRKDLFVMQNVEDMGYVALPPGTRFLNENQMGPILKSLATLHASSIAYEKQQGKTIGVEFRKWLKEVSVDPEVEWYTTGLRAVLAVAAIHPDVLDNPEAQEYIAQELPRCLDKVYCMVNPSPVHRNVFVHRDAWNANVFYHKEKPHEERSILVDFQLCRYSPPAMDFHLVTYLNLEPFSRKKMIGSLIETYYDALAEEFREMGVNPYQEQLSKQEFEQSLNDFSLFGATYNCIAATVLRLPDNYLKNLKDERPEDFHRFCNVDRSADVLRLMKNHPEFADYMYDCVGDLLALTYHKLH
Protein: Speedy protein E2 (Q495Y8)
Organism: Homo sapiens (Human)
Interaction partners:
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 2
- M-phase inducer phosphatase 3
- Speedy protein E5
Sequence:
MDRTETRFRKRGQITGKITTSRQPHPQNEQSPQRSTSGYPLQEVVDDEMLGPSAPGVDPSPPCRSLGWKRKREWSDESEEEPEKELAPEPEETWVVEMLCGLKMKLKQQRVSPILPEHHKDFNSQLAPGVDPSPPHRSFCWKRKMEWWDESEESLEEEPRKVLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGFPSWQYQRIHFFLALYLANDMEEDDEDSKQNIFHFLYRKNRSRIPLLRKPWFQLGHSMNPRARKNRSRIPLLRKRRFQLYRSTNPRARKNRSRIPLLRKRRFQLYRSMNSRARKNRSQIVLFQKRRFHFFCSMSCRAWVSPEELEEIQAYDPEHWVWARDRAHLS
Protein: Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) (Q15555)
Organism: Homo sapiens (Human)
Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10188731}. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Interaction partners:
- Putative RNA-binding protein 15B
- Microtubule-associated protein RP/EB family member 3
- Microtubule-associated protein RP/EB family member 1
- Cytoskeleton-associated protein 5
- DNA replication licensing factor MCM6
- mRNA export factor RAE1
- Zinc finger protein 24
- Cartilage acidic protein 1
- Ketohexokinase
- RNA-binding protein 15
Sequence:
MPGPTQTLSPNGENNNDIIQDNNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTPSRPSSAKRASSSGSASKSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMDILYASEEHEGHTEEPEAEEQAHEQQPPQQEEY
Protein: Protein HLB1 (HYPERSENSITIVE TO LATRUNCULIN B1) (Q9FHY8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the endomembrane trafficking machinery that is involved in protein recycling to the plasma membrane. Forms a complex with BIG5/MIN7/BEN1 and actin to modulate the function of the trans-Golgi network /early endosome at the intersection of the exocytic and endocytic pathways. May be linking post-Golgi traffic with the actin cytoskeleton.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26941089}. Endomembrane system {ECO:0000269|PubMed:26941089}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:26941089}. Early endosome {ECO:0000269|PubMed:26941089}.
Interaction partners:
- Protein Brevis radix-like 4
- Calcium-binding EF hand family protein
- Calcium-binding EF hand family protein
- AT1G11360 protein
- La-related protein 1C
- Protein phosphatase inhibitor 2
- Synaptotagmin-3
- Probable transcription factor At1g61730
Sequence:
MADTVEEPQLQNGAAPAESETEQNPIPEPQLQTEPKLTGEIPEIEADLTPEEVQSEVTDAKPEEVQSEVKPEEVKTVVTDAKPEEAQSEVKPEEVQSVVTDTKPDLTDVDLSPGGSEEIPIRSTEVEQESTTSVLKKDDDGNKTFTMRELLSELKSEEGDGTPHSSASPFSRESASQPAENNPAMDLINRIQVNDEEGRSRQRVLAFAARKYASAIERNPDDHDALYNWALILQESADNVSPDSVSPSKDDLLEEACKKYDEATRLCPTLYDAYYNWAIAISDRAKIRGRTKEAEELWEQAADNYEKAVQLNWNSSQALNNWGLVLQELSQIVPAREKEKVVRTAISKFRAAIRLQFDFHRAIYNLGTVLYGLAEDTLRTGGSGNGKDMPPGELYSQSAIYIAAAHSLKPSYSVYSSALRLVRSMLPLPHLKVGYLTAPPVGNSLAPHSDWKRTEFELNHERLLQVLKPEPREMGRNLSGKAETMSTNVERKTVKVNITEIVSVTPCADLTLPPGAGLCIDTIHGPVFLVADSWESLDGWLDAIRLVYTIYARGKSDVLAGIITG
Protein: Smooth, isoform P (A0A0C4DHD5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPKPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN
Protein: Transporter (Q9N3C7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- Serotonin-gated chloride channel mod-1
- G-protein coupled receptors family 1 profile domain-containing protein
- Aromatic-L-amino-acid decarboxylase
Sequence:
MLRWHSVRRKQHQQLQAELSSGAASMLSAPESRRVSRSMSVKAPTASEYMPLSVADKPLTLTVSTSHSIDPNEPIAALGGLTPTKEGRVAALRRRSSMVRDKWATKMEFLLAVVGYAVDLGNIWRFPSVCYKHGGGAFLIPYFIMLMIGGLPMFYMELVLGQFHRSGCVSIWRKVCPLFRGIGYGICCICTFIAIFYNAIIAQAVYFAIVSLSKIWDSEVPWASCGNPWNTPRCSDDLNVTISRNGTPLTTPSEEYYLYKVLEVQKSTGFDDLGGVKTSMAVCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYIILSILLIRGLLLPGAKNGLYYYVTPDFEKLKDPAVWSAAATQIFFSLGPGFGVLLALSSYNDFNNNCYRDAVTTSIINCATSFFSGCVVFSTLGYMSLLTNKPINEVVGEHDASLIFIVYPQALATMDYSCFWSFIFFVMLITLGIDSTFAGIEAFITGFCDESRFLSKNRKWFVLVICIIYYFLSFPAISYGGQFVIPFLDEYGVSLSVLFIVTCEMIAVCWFYGVDQFSKDIRAMLGFYPGIYWRVCWTCSPVFISVIFIMTVYNSSFKPIQMASYTFPWWSVILGWFLRLLSVLAIPVFAIIYLLSGTGTLYERFRWAITPQQRRNSATSLAADPTQIIDSSLLDPIHTLTPV
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 (A1L188)
Organism: Homo sapiens (Human)
Function: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:27499296}.
Interaction partners:
- Arginine-hydroxylase NDUFAF5, mitochondrial
Sequence:
MSANGAVWGRVRSRLRAFPERLAACGAEAAAYGRCVQASTAPGGRLSKDFCAREFEALRSCFAAAAKKTLEGGC
Protein: Homeobox C11 (J3KMZ0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPSRRPPHPQEALPLFEIPDPGTGARVFLQRVYQQREAAAAVPDAEPDGPTSENLVSEQKDERKETEQRPAAVFLGKSSAVTCRPGPFGGGGRGKLFYFIFIFYFLTRLLSAGGKLDCGQGWPPPLWPALHSGTSWTLYLTLAVGQGPGLERG
Protein: Acetylcholine receptor subunit epsilon (Q04844)
Organism: Homo sapiens (Human)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Acetylcholine receptor subunit alpha
- 43 kDa receptor-associated protein of the synapse
- Acetylcholinesterase collagenic tail peptide
- Protein Dok-7
- Muscle, skeletal receptor tyrosine-protein kinase
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit delta
- Neuronal acetylcholine receptor subunit alpha-6
- Misshapen-like kinase 1
- Neuronal acetylcholine receptor subunit beta-3
Sequence:
MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCIQP
Protein: Possible iron-regulated short-chain dehydrogenase/reductase (O05842)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein
- Aminoacyl-tRNA hydrolase
- Probable fatty acid synthase Fas
- Uncharacterized protein Rv2012
- 3-hydroxyacyl-thioester dehydratase Y
- Probable acyl-CoA dehydrogenase FadE25
- Probable conserved membrane protein
- Conserved serine rich protein
- ECF RNA polymerase sigma factor SigH
- Anti-sigma factor RshA
Sequence:
MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
Protein: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) (Q726X3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Interaction partners:
- 3-isopropylmalate dehydrogenase
- 3-isopropylmalate dehydratase large subunit
- 2-isopropylmalate synthase
- Citramalate synthase
- Ketol-acid reductoisomerase
- Dihydroxy-acid dehydratase
- Threonine synthase
- NADP-dependent malic enzyme-related protein
- L-lactate dehydrogenase
- HMGL-like domain protein
Sequence:
MRYAGTAHKVGDHIDTDAIIPARFLVTTDAQKLGENCMEGLEHGWVARVKSGDIMVGGRNFGCGSSREHAPIAILGAGMPVVVAHSFARIFYRNGFNMGLLLLEVGDDVDKIADGDDIEVDAASGVITNRTTGATITCAPVPQSMRELLDTGGLVPYVRARLERENG