wanglab/gogpt-training-data huggingface dataset:
Protein: Autophagy-related protein 20 (Q9USM8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Sorting nexin C1711.11
- Sorting nexin-4
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 9
- Taz1-interacting factor 1
- Autophagy-related protein 8
Sequence:
MAQDDSYEEKPEVISSDSGGSGYSTEIQIVGTVTSSDGSYVEYEIVHQKRSVWRRYSDFESLVKLMRRQYPAAIVPPIPGKQSLLSYAKHPRKAKSDAEFLNFRSRMLELFLRQCLLHPCIRSNPIFDKFIHSTVSWHVTLSSLDLPKDSNTDPLRLPPIATEHDPFAHLRSSMPLVMANSLSPPSSRALKPIHSLSNPSTASSLEPSSPLGSEDECHPPTSDMQPTHELNESPSTPTAPDFPHYNSSPSELSPTQRRSSISNGKDAPSPVLKDLTSYTQEVIVCRKFLHHSLSPSIHSTLSSISKMESCLSKLGSAFHSLTALNEIQLANHLQVIANAFEFSGMYAKEFEQEFNSSVYEKMVQSMQLAKCAADALKYKQLKIQQRDFLQDQLIHSNTMSATDSMVAASPTIHPATRLNTIQRAVVSQAKKGYTIFGRLQNVLHDFVEGETSISKESLQQHKNTIENQLAAANWDCQKIDEFMDAELKFYKECQTSQWEEIIKSVHECIYKWAQTNLQRWLRTREELENLSKDI
Protein: Alpha-crystallin B chain (Alpha(B)-crystallin) (P23) (P23927)
Organism: Mus musculus (Mouse)
Function: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P02511}. Nucleus {ECO:0000250|UniProtKB:P02511}. Secreted {ECO:0000250|UniProtKB:P02511}. Lysosome {ECO:0000305|PubMed:31786107}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P02511}.
Interaction partners:
- Alpha-crystallin A chain
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Caspase-3
- Heat shock 70 kDa protein 1B
- BAG family molecular chaperone regulator 3
- Titin
- DnaJ homolog subfamily B member 1
- Heat shock protein beta-1
- Gamma-crystallin S
Sequence:
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVAAAPKK
Protein: phosphatidate phosphatase (EC 3.1.3.4) (A0A0B4JD00)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSLARVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVDIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNKYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSYCSMTYIVDQLFPPVKLDEASAEFSNFNYWRDPIPDLEIPELETALVPPSTKVDMATLRPIPEK
Protein: Vesicle-associated membrane protein 4 (VAMP-4) (O70480)
Organism: Mus musculus (Mouse)
Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles (By similarity). {ECO:0000250}.
Interaction partners:
- Syntaxin-6
- Syntaxin-5
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-16
- Syntaxin-4
- Synaptosomal-associated protein 23
- Syntaxin-12
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Syntaxin-3
- Syntaxin-7
Sequence:
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALAAAILLLMIIILIVVKFRT
Protein: Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein) (Q96M53)
Organism: Homo sapiens (Human)
Function: May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
- BOS complex subunit NCLN
Sequence:
MATDVQLADYPLMSPKAELKLEKKSGRKPRSPRDSGPQKELVIPGIVDFERIRRALRTPKPQTPGTYCFGRLSHHSFFSRHHPHPQHVTHIQDLTGKPVCVVRDFPAPLPESTVFSGCQMGIPTISVPIGDPQSNRNPQLSSEAWKKELKELASRVAFLTKEDELKKKEKEQKEEPLREQGAKYSAETGRLIPASTRAVGRRRSHQGQQSQSSSRHEGVQAFLLQDQELLVLELLCRILETDLLSAIQFWLLYAPPKEKDLALGLLQTAVAQLLPQPLVSIPTEKLLSQLPEVHEPPQEKQEPPCSQSPKKTKISPFTKSEKPEYIGEAQVLQMHSSQNTEKKTSKPRAES
Protein: Zinc finger MYND-type containing 8 (H7C4X9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD
Protein: La protein (Q38C07)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS2
- Uncharacterized protein
Sequence:
MPLSSENKQKLQKQVEFYFSDVNVQRDIFLKGKMAENAEGFVSLETLLTFKRVNSVTTDVKEVVEAIRPSEKLVLSEDGLMVRRRDPLPESIQTDHQTVYVKPVPPTATLEQLTEFFSKHGTVQAVWRRYFAGKKDAPPESRTKPSVFVVFNSSEEAEAFQKAPPMYDDVQLTAEMKTTYLERKAEEIAAKKSSKTKNGGATDRAEKKTPPMPLGSSYRVSGCGEMESFATVKNLWPVEEQKGIRYVFMPDKESALLIFQDTQTGEKMVADLKSRGTTLNGKQPDIKKLEGDDEQKLLENVEKEIVDRAMQSANNRSGRGGRGGRGGRGHKRSRE
Protein: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinate-coenzyme A transferase) (Succinyl-CoA:3-oxoacid CoA transferase) (Q29551)
Organism: Sus scrofa (Pig)
Function: Key enzyme for ketone body catabolism (By similarity). Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (Probable). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
Interaction partners:
- D-beta-hydroxybutyrate dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase 2
- hydroxymethylglutaryl-CoA lyase
- Dehydrogenase/reductase SDR family member 6
- Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Acetyl-CoA acyltransferase 1
- Uncharacterized protein
Sequence:
MAALTLLSSRLRLCASAYRSGGAWSQGCAGYFSTSTRRHTKFYTDAVEAVKDIPNGATVLVGGFGLCGIPENLIGALLKTGVKELTAVSNNAGVDNFGLGLLLQSKQIKRMISSYVGENAEFERQYLAGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSIAIASKPREVREFNGQHFILEEAIRGDFALVKAWKADQAGNVTFRKSARNFNLPMCKAAETTVVEVEEIVDIGSFAPEDIHIPKIYVHRLVKGEKYEKRIERLSVRKEEDVKTRSGKLGDNVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGILGLGPYPLQNEVDADLINAGKETVTVLPGASYFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKLVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDSKKGLTLIELWEGLTVDDIKKSTGCDFAVSPKLIPMQQVTT
Protein: Transmembrane protein (Q1PF01)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- E3 ubiquitin-protein ligase ATL6
- Dynamin-2B
- E3 ubiquitin-protein ligase ATL31
- Phosphoinositide phospholipase C 2
Sequence:
MSLLLLFCCFFTSLSISHSHGASTIHISPTQPPAASSEKTGSVMKFIVAEAPLLGPAGFNNPQVIEVASVALAAQRTYRKDPLNGFEKYTGGWNISNQHYWASVSYTAVPLFVLAAVWFLGFGICLLVICMCHICHRTNSVGYSKVAYVVSLIFLLIFTVIAIIGCVLLYSGQIRYNKSTTETLEYVMSQADSTISQLRAISDYLASAKQAAVLQVLLPANVQTEIDQIGVKLDSSVATITEKSTNSSNHIRHFLDSVRVALIVVSIVMLVVTFLGLVSSIFGMQVIVYTLVILGWILVTGTFILSGTFLVLHNATADTCVAMSEWVERPSSNTALDEILPCTDNATAQETLMRSREVTGQLVELINTVITNVSNINFSPVFVPMYYNQSGPLLPLLCNPFNHDLTDRSCSPGDLDLNNATEAWTSFVCQVSQNGTCTTTGRLTPALYSQMASGVNISTGLIRDAPFLVQLQDCSYAKQTFRDITNDHCPGLQRYGYWVYVGLAILATAVMLSLMFWIIYSRERRHRKEALPEFSESKEIVRVNF
Protein: Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (mNKCC1) (P55012)
Organism: Mus musculus (Mouse)
Function: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:A0A0G2KTI4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- STE20/SPS1-related proline-alanine-rich protein kinase
- Serine/threonine-protein kinase OSR1
- Serine/threonine-protein kinase WNK1
- Serine/threonine-protein kinase WNK3
- Serine/threonine-protein kinase WNK4
- Gamma-aminobutyric acid receptor subunit gamma-2
- Anion exchange protein 2
- Sodium bicarbonate cotransporter 3
- Cystic fibrosis transmembrane conductance regulator
Sequence:
MEPGPARPRLAPAARPGWGRAAGCRRRGGPARHGRASGQEDATTAGRQAGGGVRGEGTPAAGDGLGRPLGPTPSQSRFQVDPVSENAGRAAAAAAAAAAAAAAAGAAGKETPAAGKAGGESGVAKGSEEAKGRFRVNFVDPAASSSADDSLSDAAGVGGDGPNVSFQNGGDTVLSEGSSLHSGGGSGHHQQYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVAYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIADFVIGTFISLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRDATGNVNDTITTELTNCTSAACKLNFDFSYCESNTCSYGLMNNFQVMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVNVDYSKKSDQDTCKSSGEKSITQKDEEEDGKTPTQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFDDMIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPVLLVRGNHQSVLTFYS
Protein: GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) (Q9H116)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14522971}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:17674968}. Nucleus, nucleolus {ECO:0000269|PubMed:17674968}. Note=Nuclear localization depends upon NCL. {ECO:0000269|PubMed:17674968}.
Interaction partners:
Sequence:
MESGAVLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVADFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLESVLLELQNFSESQEVEVSSGSQVSAAPAPRASVATDGPHPSGLTDSLDYPGERASNGMSSDLPPKKSKDKLDKKKEVVKPPYPKIRRASGRLAGRKVFVEIPKKKYTRRLREQQKTAEGDVGDYRCPQDQSPDRVGTEMEQVSKNEGCQAGAELEELSKKAGPEEEEEEEEEDEEGEKKKSNFKCSICEKAFLYEKSFLKHSKHRHGVATEVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCELCGKKFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTHTGDRPYGCTECGARFSQPSALKTHMRIHTGEKPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHNRIHTGSKPFKCEVCFRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQLNALQRHRRIHTGERPFMCNACGRTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSPKNDDGHKTEQPDEEYVSSKLSDKLLSFAENGHFHNLAAVQDTVPTMQENSSADTACKADDSVVSQDTLLATTISELSELTPQTDSMPTQLHSLSNME
Protein: SAC3/GANP/THP3 conserved domain-containing protein (Q585F7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- Transcription initiation protein, putative
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Plastid-encoded RNA polymerase subunit alpha
- DNA-direcetd RNA polymerase II, subunit 9, putative
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- Spt4/RpoE2 zinc finger domain-containing protein
- Telomerase-associated protein, putative
Sequence:
MSGLSVRAALSTPPFSTFCEFKVDEPPRRGQLAALCGGNRANNTGDGISQLPAVEPYGRSAAGVVVEPAHLRTPTALEKSMHFLVQHYLRKPHGSAVFLAPFDVWRYLWDRMRQVRTNWVPQLPPVGAELRDDGCGERIEGNVNEGGDLRGGILQQQCETITTKQMVRRESRRRLRWLEFTVAALSVGGANLCRSVEGCRHFVQEKQNFFESIAQCFSDLVVSYRAEQRLRNSEMFSAVILFYGLSQLTKIENRAGFFRVSQVTVSSVSGGTTVAAPTSVFEPPSSSVDFGSVYRELSYIPCMARSRHVRIALKIIHCWCQREWFRFFYLCRTARLTVLQRAILSHSFSYARFRAVVDLVTANVVVYGKGRVRGSMAVSELAELLLFTPKHCVELLLTMGLGPQLSEDRTVLRLSQQDSSPYTTQEQIFRHLEETGGKPRLCLPTLSSFVGFTVWQRAFELFPSAFDGDAAGTVSGASSPPVTDLENMRCPVNLMQLLEPYCPPYNEDVAALELLDAGSEWFDGIQASRERMLAWCVNNASRAEVKREGMETEAQDDSRWGGNATMGCEYDGVSGSMKGDELGEELREVVAEMDRESVSTRSSVFDDDDETELTHNETGFGLHAEEVCGEEDVLNNESDYGEEDEALREANILINSLQNSSIYQLASSNMQKETTKELPDTAAATDPIKGADEAHAAAQGSSQRNNEDEKQEQQKLDENASELVLYKPSSGAETAVTPLPSDHPGVMSPTLHATVEAPESESSRSTENSEVEIVAVAERPQQANKKECESGERNETLAQDQSNRSMLFGSQSAVPAFFGVSKFPPISFGNLHSGFPGSPTQQKANVEENVQGKGDSALKRSRSEEIDNNATIPGSYLSRQQVDTVLDTTTSSVDDRIMLLPSEVEEESEQRTLKAEVQQKEDAPRQRMRAERGKVDTDTSERSVPTTSHCATSSDVDPAPRLPEAGGPSLVSYKDVIKACVDEMKGKEQRWPRMSEADVSLLPRAPSKPSREQSLQVHSPLPFCFSTGAEYSAVALLLQELPQWVDTFTSYLVSFYSASYSDVTACRHLTDIICRGSRSQEITGWMCRGFTPSMIPYSETGEDSLLNFNEELSHDESTNAPTRETPILRLTSKIIVFGSDLREHDDRDEHTGTDGASLFASSGLSGGAGSRFVSSQLSDRQHPSLGHWIAALMLPPAERARVLREGILYHSKTPQSTDMDACFDEGGGSAAELGKSRDSDHIGIWEQMHVLRAADAKTTPAAWRLLSTAAAAWRRPLPSGSTKMLLQTQIALHAVDFRDVPRLRWTQDTQTSSPAACKVAACECQREHPTVIIALDTTRHKEFAAGMEVLRSLISQSVEQRAVLLAGVIVVLYTESVQEDEEKKKTVEEFFWSTWERCSKVAEESELQAAATLYDDKMPPWRAMYQNTIRRAVVKARSQAQMCSGSSPDGSFLSATSLPSSIESGDGVDSNMKRSLPYRIQKLIKSRRVMPSGAPPDPTLLVVPIHSLMDKNTRAFRSQYGNGGFTAFGVIALKEMLNSSVHSLLQDYEVRCRDFLRKNKFDAW
Protein: Uncharacterized protein, isoform A (Uncharacterized protein, isoform C) (A1Z9I6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- MIP04834p
- Ubiquitin-conjugating enzyme E2-17 kDa
- Nuclear pore complex protein Nup214
Sequence:
MDALQDEVESLEAILMDDVCIKRTPSGEVEQIETTVLPLTGEEEEQQYVCVTLQVHPTPGYPEESPTFKLLRPRGLDDARLEAIRSACNAKIKESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFADGDEFTRTECFHYLHSYCLARHLNALRRNYQEEFDKLPAWLQKTADPFQALCPVCREHIGDETDSLKCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGSAVISIETEEDIRRRRRREEAEAAKKLEGPSKEEVIKPTTSSTFAPVVQETHRIMPEPTNNNYHHNRRHYRGGRRHHHHHQHGHHHRAERERGEQNAAAAPANAGGSTSNAVNTNSKQAKAQSASSGLAR
Protein: Kekkon 5, isoform A (Kekkon 5, isoform B) (Kekkon 5, isoform C) (Kekkon 5, isoform D) (LP23752p) (Q9VWI6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Disks large 1 tumor suppressor protein
- Reticulon-like protein
- Protein tyrosine phosphatase 36E, isoform A
- Tyrosine-protein phosphatase Lar
- Flotillin-2
- Flotillin-1
Sequence:
MMGNRTERSGRRLGMILLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRAPSWAPSTSGAAGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQGGAGQQYSMRDRPLPATPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQQQQQQRLGSMDTEPLYGVRQQGITILPGSSISGAGLGHAAYLSPGSGAAVSPSHASSSGDSPKAAKIPPRPPPKPKKKMSVTTTRSGQGSTSQLFDDEGEDGTEV
Protein: Eukaryotic translation initiation factor 4 gamma 2 (D3DQV9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
Protein: HrpX protein (Q8PBF5)
Organism: Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Interaction partners:
- Serine kinase
- DUF3313 domain-containing protein
- Acidic amino acid rich protein
- Kinase
Sequence:
MILSTYFAAISALSYADRLPIYTSRMLVGAWPQGLQHLQQRREGQAAPDGSDDEVALLGASADALLILEYQEEAEDAYRQASKAMRGHQRQLRLLSCRNTAWLMLSQRRLSAALNCFAQLAMDRDTPAVLCGESLLGKALTHFHLGQSTLALQTLERAQEVVSELELGAADWTRVVGALRLDLIAQLRIRRGERMSDHVFWQATLRQEDAAHTFEASELRACIADLSESMPVLAQRMRHVRNLLRIAGGDIFGFDAQIDALPAAATGCPPCARQDAQVELALAALAVGRADLAERALAGAGRHHAPRWNLEFEYCQAKISQALGRAEQALLLYNRYALGAVQCLRSEVQAPRLLESGTPAHVSDDISARLPAKYRRAYAYMITNAHRSDLSINEVAAQIGVTGRALQQAFKSATGLSPTQVLRRYRMQGIRDELLADGGCGSVLQAASRWGVGSRSALAKGYRQHFNEAPMETLQR
Protein: Bcl-2 (ORF 16) (ORF16) (Q76RI8)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MDEDVLPGEVLAIEGIFMACGLNEPEYLYHPLLSPIKLYITGLMRDKESLFEAMLANVRFHSTTGINQLGLSMLQVSGDGNMNWGRALAILTFGSFVAQKLSNEPHLRDFALAVLPVYAYEAIGPQWFRARGGWRGLKAYCTQVLTRRRGRRMTALLGSIALLATILAAVAMSRR
Protein: Phenazine 1,6-dicarboxylic acid hydroxylase PhzS (EC 1.14.13.-) (Flavin-containing monooxygenase) (Phenazine 1-carboxylic acid hydroxylase) (EC 1.14.13.218) (A0A172J1S0)
Organism: Lysobacter antibioticus
Function: Involved in the biosynthesis of phenazine natural products including myxin, an N(5),N(10)-dioxide phenazine antiobiotic, which has antimicrobial activity. Catalyzes the decarboxylative hydroxylations of phenazine 1,6-dicarboxylic acid (PDC) to produce 1,6-dihydroxyphenazine (DHP). Low activity with phenazine 1-carboxylic acid (PCA) to produce 1-hydroxyphenazine.
Interaction partners:
Sequence:
MTTATQTDIVIAGAGIGGLTTALALHAQGIERVVVLESANEIRPLGVGINVQPAAIAQLFALGLGEAIAATGIATRELRYLDHAGITLWTEPRGLAAGDPYPQYAIHRGELQMLLLAAVRERLGADTVRTGLRVQDFEHTRTGIRVHAQERGNGGSTVSFEATALVGADGLHSAVRARLHPDRCELLPARIQMWRGLTEVDEFLDGRSMIVANDDRSTRLIAYPCSARHAQHGRALINWVCMVPDVAQDLTREASWDCSGQLKDVLPYFADWKFGWLDVPDLLSRSTQILEYPMVDRDPLPRWGIGRATLLGDAAHLMYPVGANGASQAILDAVSLANELGDNSDTVEALQRYEAVRRPPTTAIVQANRDRDTAERAIATRPDPEKTAALAAITSSYRSIVDRSHVQ
Protein: Advanced glycosylation end-product specific receptor (Q5SSZ2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVVEESRRSRKRPCEQEVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRH
Protein: DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs) (Zinc finger protein-associated with nuclear matrix of 75 kDa) (O88291)
Organism: Mus musculus (Mouse)
Function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). May also play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:10798446, ECO:0000269|PubMed:9809746}.
Interaction partners:
- Cell cycle and apoptosis regulator protein 2
Sequence:
MDFEDDYVHSTCRGAYQDFNGMDRDYGPGSYGGLDRDYGHGSYGGQRSMDSYLNQSYGMDNHSGGGGGSRFGPYESYDSRSSLGGRDLYRSGYGFNEPEQTRFGGSYGGRFESSYRNSLDSFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRENYSSYSSFSSPHMKPAPVGSRGRGTPAYPESTFGSRSYDAFGGPSTGRGRGRGHMGDFGSFHRPGIIVDYQNKPANVTIATARGIKRKMMQIFIKPGGAFIKKPKLAKPMDKMNLSKSPTKTDPKNEEEEKRRIEARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESSSHQETLDHIQKQTKFDKVVMEFLHECMVNKFKKASIRKQQTLNHPEAYKIIEKDIMEGVTADDHMMKVETVHCSACSVYIPALHSSVQLHLKSPDHSKGKQAYKEQIKRESVLTATSILNNPIVKARYERFVKGENPFEIQDHPQDQQIEGDEEDEEKIDEPIEEEEEEEEEEEEEGEEAGSVEEEGDVEGEEGTAEAAAAGEADAVGEAEGAGEAEEAEEEEEEEGTQEFAAQACATEQCEHRQM