wanglab/gogpt-training-data huggingface dataset:
Protein: Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109) (G-protein coupled receptor 109A) (G-protein coupled receptor HM74) (Niacin receptor 1) (Nicotinic acid receptor) (Protein PUMA-G) (Q80Z39)
Organism: Rattus norvegicus (Rat)
Function: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Olfactory receptor 51E2
- Pro-neuropeptide Y
- Sodium-coupled monocarboxylate transporter 1
- Olfactory receptor
- Appetite-regulating hormone
- Endothelin-1
Sequence:
MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
Protein: Integration host factor (Mycobacterium integration host factor) (mIHF) (P71658)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30242166}.
Interaction partners:
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS10
Sequence:
MALPQLTDEQRAAALEKAAAARRARAELKDRLKRGGTNLTQVLKDAESDEVLGKMKVSALLEALPKVGKVKAQEIMTELEIAPTRRLRGLGDRQRKALLEKFGSA
Protein: Meiotically up-regulated gene 172 protein (Q9P6R4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized WD repeat-containing protein C32H8.09
- Kinesin-like protein 1
- Kinesin-like protein cut7
- Ribulose-phosphate 3-epimerase
Sequence:
MTTPIVFCNPSNIEESLLYINKSLFSKGVIQAEKLRLSHDIRDNCNIVNIIYRLLRATDEERLEKESLLDAIKNNEYEKQRDNNTIKRLKNELELYQNECQLQLNKVRTLERDQAELITQNKGLKDVNAKNELTLKALKNQLSVSLRQHEQQMETLKGNYGLVKARKGRNLNSMLIVKEPIKQNTNAPILPETASFLQQNDENSNFLNSRVNNDEFQLLKGLNNELKKSNGTLLTCLSGTLNSLVEMLSPLYERPNSNPFEVCELNAILLDAKIQNQLLFIRNLLHERKYVSIDELDAILEENEKNKHLINILQKENKRVFEFLTNMHDKF
Protein: NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1) (NADH-ubiquinone oxidoreductase subunit B14.5b) (O95298)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
Sequence:
MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR
Protein: Septin A (Septin-2A isoform X1) (B7ZR20)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cell projection, cilium membrane {ECO:0000256|ARBA:ARBA00004309}. Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Midbody {ECO:0000256|ARBA:ARBA00004214}.
Interaction partners:
- Uncharacterized protein.
- Septin-type G domain-containing protein
- Septin-type G domain-containing protein
- Septin-9 isoform X1
- Septin 9 S homeolog isoform X1
- CEP209_CC5 domain-containing protein.
- SH3 domain-containing protein.
- C2 domain-containing protein.
Sequence:
MSKQQAQFTNPETPGYVGFANLPNQVHRKSVRKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVVPGAADKIERTVDIEASTVEIEERGVKLRLTVVDTPGYGDAMNCVDCFKPIISYVDNQFERYLHDESGLNRRHIVDNRVHCCFYFISPFGHGLKPLDVEFMKALHNKVNIVPVIAKADTLTLRERERLKRRVLDEIEEHGIKIYQLPDAESDEDEDFKEQTRLLKASIPFTVVGSNQLIEAKGKKVRGRLYPWGVVEVENTEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKKGVTSSKVEHVEVTKDQILQEKEAELRRMQEMITRMQAQMQIQGQSGDAQHL
Protein: Candida glabrata strain CBS138 chromosome F complete sequence (Q6FUR5)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDRNWYYQTPYDDSARMYQVVQAPYYVYPRVIYDSQGSPSGASPNGANVPGTSVSSVSGAVPNVSGALSGVSNANGASSGVRTQSTGDYLYSYSNVPNYINSRPMLLSKDQRGSTGSIASLPHAVGSASEGTMHSVTSTGTSMSGPTTNVSMNGNAATSTMSDDMGSKKVSKLKFKSSVMKDGDVEKNEYTLDMSDTAARRRRQNREAQRAYRERKATRINELEKTVSLLQDTIKEYELQMNTIHMRLQTLQEKNDILEKINQELITNKGSQSIPQEQLQQLQQQMQAQSTQGNPPPSTHIQHVGYQHVVQADQPNRNLMESINEFKPMTAVTLKREDQVNKITEDNESQKRSADKAFLQLNPKFQKQLSTPVSPDVNSLLLANNETVNVEENEIDMNYMAKKAKTVKEGKCSGSSDCCSKKRQEAGVDPKNSNWKPGSCGTCSSDPYSKAFCQSMFAERRKLNQGREPNLTPDEVQKLRSDMMNAASETPTDQNIYAGTPAEDNVKANVERQSANASNVNDNAAGRGNAVTPISPPSVADTASATTKERKQSIEKLEVTSERDVSNWENRSNSDGSATSAQDQPTRSTFDRIKKHMEYKRNFPTNSGNSPSNLDNILAKPV
Protein: Hsc70-interacting protein 1 (C4NYP8)
Organism: Drosophila melanogaster (Fruit fly)
Function: One HIP oligomer binds the ATPase domains of at least two Hsc70 molecules dependent on activation of the Hsc70 ATPase by Hsp40. Stabilizes the ADP state of Hsc70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of Hsc70 with various target proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P50503}.
Interaction partners:
- LD28549p
- Heat shock 70 kDa protein cognate 2
Sequence:
MAFTMQTGDLKKLKYFIDFALENPTFLNMPQLQFVKDFVEKFGGTVPPGQFNGGSAGGKCPFGGVAGAKANEPANAPEDSEDEKSLSDPESDVELDMEGVIEADSDPAQPMGNYSKKATEEEVEQASELRAQAASAYGQQKFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIRDCDVALELNSDLAAGYKFRGRARRLLGDFELAAHDLRQACKLDFDEETDEWLKEVTPNAKKIEQHRLKQERRQAERKIKERQRDQRRARKEQEKHNASSGGSSGEFSGGNPGNGNMSDILGAMSDPEVSAAIQDILSNPGNITKYASNPKIYNLIKKIVPGGDVGAAFGQAGEKAGKPSEPKPKKDSADFVDDGLD
Protein: Facilitator of iron transport 1 (Q04433)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the uptake of non-siderophore sources of iron and the siderophores ferrioxamine B and ferrichrome. Has a role in the retention of iron in the cell wall and periplasmic space.
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Interaction partners:
- Siderophore iron transporter ARN1
- Facilitator of iron transport 2
- Iron transport multicopper oxidase FET3
- Iron-regulated transcriptional activator AFT1
- Siderophore iron transporter ARN2
- Siderophore iron transporter ENB1
Sequence:
MKLSSAFVLSAITVAALGESITTTITATKNGHVYTKTVTQDATFVWAGEGAAVTSAVTEASTVAATSAAAETSVAAETSIVEPSTSAQGTSADEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGERAPASTVATVETSVAAETSVAEPSTSAQGTSADEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGERAPVSTVATVETAASPVTSVAEPSASTDEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGERAPASTVATSSISAIEIPSTTEASIVEASSAVETSSAAETSSAVETSSAVETSSAVETSSAAETSSAAETSSAVETSSAVEISSAVETSAVETSSSSSTIETTSVKSLSPTQTSLSSSVQASSPIETSSAAKTSSVVPTFSSTTTENSSNSKSTSAVVASTTTSSESSATIVTPTRIGQAYTESSSRDAQSVRTHESNNWSSSSSASTKMVSSITRVQTTTAGIFTNGKSSTTPQIVNYTGAADSIAAGTGLMGAALAAVIFL
Protein: Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) (Q28362)
Organism: Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:20584908}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Recycling endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Early endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression. {ECO:0000269|PubMed:20584908}.
Interaction partners:
Sequence:
MPLGVRGTRREFRFPVWGLLLLALWMLPRALGVEEIPGPDSHEKQGFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLILGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTVWNAATTGLSLYGVYLSGIMGDLSIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNDVLFIIVFGESLLNDAVTVVLYNVFDSFVSLGADKVTGVDCVKGIVSFFVVSLGGTLIGIIFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPAIWTWNTAFILLTLVFISVYRAIGVVLQTWLLNKYRMVQLEIIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKKSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKVLSKLLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNIVNVDFSTPRPSTVEASVSYLLRENVSTVCLDMQALEQRRKSIRDTEDTVTHHTLQQYLYKPRQEYKHLYSRHELTSNEDEKQDKEIFHRTMRKRLESFKSTKLGINQTKKTAKLYKRERGQKRRNSSIPNGKIPMESPTRDFTFKEKELEFSDPEETNEYEAEEMSGGIEFLANVTQDTATDSTTGIDNPVFSPEEDQSIFTKVPPWLSPEETVVPSQRARVQIPYSPSNFRRLTPIRLSTKSVDSFLLADSPEERPRSFLPESTHM
Protein: RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) (Q9BXT6)
Organism: Homo sapiens (Human)
Function: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99MV5}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV5}.
Interaction partners:
- Piwi-like protein 2
- Tudor domain-containing protein 1
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
- Probable ATP-dependent RNA helicase DDX4
- Putative ATP-dependent RNA helicase TDRD12
- Piwi-like protein 1
- ATP-dependent RNA helicase TDRD9
- Piwi-like protein 4
- Mitochondrial cardiolipin hydrolase
- Protein maelstrom homolog
Sequence:
MLSLAAKLVAFFWRTADTPREEAGQLEPELAEGDTKLKTVRGVVTRYCSDYGMIDDMIYFSSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSRNHGSPSDCGPRVLIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAEYRIRPGTWSSEATSVKPLRYKRVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRALCMTLVKRRDAAPVHEATHFYGTILLKNKGDIEVTQVTHFGTLKEGRSKTMVIWIENKGDIPQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSFVSVPEKENSSDENINSLNSHTKNKTSQMSESSLVNNRGISPGDCTCKGENGEKDNILSRKQMTEPEPGGLVPPGGKTFIVVICDGKNPGRCKELLLLCFSDFLIGRYLEVNVISGEESLIAAREPFSWKKLKSSQALTSAKTTVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIYAEMELKEYNMSGIILRRNGDLLVLEVPGLAEGRPSLYAGDKLILKTQEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEHVIHLGVKVLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSKKNRKTMTDQAEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKPYCRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEPECLIPLGLMSDISGQIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRYCCLLAHSISSQVSASDIGVITPYRKQVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCDLPPALQSLQNCGEGVADPSYPVVPESTGPEKHQEPS
Protein: Microtubule-associated protein (O02592)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU000686}.
Interaction partners:
Sequence:
MSTPQSEPGSEPGSPGENENSMETQYSQGSFPEVAVEPEPEPEPEPEPEPEPEPEPEPEPEPKPKPEVEPVPQPEPEPEYQPEPEPEPEVEPEPEPEPVPEPEPEPEPEPEPVVEKEEEVVVESPPREQEPEKSGKSKPSSPIPDAPTMEDIAPRELESLNFSETSGTSDQQADRIMQNNENERVEEKKQMSPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKSTSTRSIDNVGRMTPKVNAKFVNVKSKVGSVTNHKAGGGNVEIFSEKRLYNAQSKVGSLKNATHVAGGGNVQIENRKLDFSAASPKVGSKTNYQPAKSDVKIVSEKLTWQAKSKVGSMDNAAHKPAGGNVQILSQKLNWKAESKVGSKDNMNHRPGGGNVQIFDEKIRYVSTDSSRNHSTLDISSL
Protein: LAMP family protein lmp-1 (Q11117)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00740}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740}.
Interaction partners:
- Target of rapamycin homolog
- Nitrogen permease regulator 2
- Protein SEC13 homolog
- DAF-15
- GATOR complex protein NPRL3
- Ras-related protein Rab-7a
- WDR59/RTC1-like RING zinc finger domain-containing protein
- DEP domain-containing protein
- Nucleoporin SEH1
- GATOR2 complex protein MIO zinc-ribbon like domain-containing protein
Sequence:
MLKSFVILFAFLASASATASHYYVTNNNTGLTCIILDGDFQFNLVFNEKNTTEKFTVTFNETVSVEGDCNGVRNNQSVQTLNIKFNPEGQSARYAKEWELDIVFGSSSNVAFEIIDYTLTTQRTDLVPYFGKFVRDANAAGDVTATQTNAYKCSTAKLGLVGGSTIDIKTSNVIAFAQMNGTVFPTDQVYEVCYLDARTNEVVPIVVGACLAALVVVVLVGYLIGRARAKRQGYASV
Protein: Cecropin-B (P14956)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Subcellular location: Secreted.
Interaction partners:
- Cecropin-C
- Nuclear factor NF-kappa-B p110 subunit
- Diptericin B
- Dorsal-related immunity factor Dif
- Diptericin A
- Defensin
- Drosocin antimicrobial peptides
- Attacin-A
- Metchnikowin
- Attacin-D
Sequence:
MNFNKIFVFVALILAISLGNSEAGWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATARG
Protein: Ataxin-3 homolog (EC 3.4.19.12) (Machado-Joseph disease-like protein) (O17850)
Organism: Caenorhabditis elegans
Function: Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By similarity). Acts as a histone-binding protein that regulates transcription (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17234717, ECO:0000269|PubMed:21526185}. Nucleus {ECO:0000269|PubMed:17234717, ECO:0000269|PubMed:21526185}. Nucleus, nucleolus {ECO:0000269|PubMed:27669035}. Note=Localizes predominantly in the cytoplasm (PubMed:17234717). In the germline, following ionizing radiation-induced DNA damage, localizes to foci within nucleoli where it colocalizes with cdc-48.1 and/or cdc-48.2 and ufd-2, proteasome alpha subunit and ubiquitinated proteins (PubMed:27669035). {ECO:0000269|PubMed:17234717, ECO:0000269|PubMed:27669035}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- UV excision repair protein RAD23
- ubiquitinyl hydrolase 1
- Transitional endoplasmic reticulum ATPase homolog 2
- Transitional endoplasmic reticulum ATPase homolog 1
- Forkhead box protein O
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin conjugation factor E4 ufd-2
- Heat shock protein 70
- Ubiquitin fusion degradation protein 1 homolog
Sequence:
MSKDDPINSIFFEHQEAALCAQHALNMLLQDALYKWQDLRDLAIQMDKMEQQILGNANPTPGRSENMNESGYFSIQVLEKALETFSLKLTNIENPAMVDYKNNPLTARAYICNLREHWFVLRKFGNQWFELNSVNRGPKLLSDTYVSMFLHQVSSEGYSIFVVQGVLPRSDADDLISLCPVVPPKVTPKKEQKLEKVMTKFFNTVGKRLGGGSGAPPDSQEEKDLAIAFAMSMETKDGSEVSRSSAEIDEENLRKAIELSQAPGPSEPAEIPLLTRSRSSTPPGASEPFSNAEQQRRDRQKFLERFEKKKEERNDEK
Protein: Probable D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD) (Q9HYN9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- L-serine dehydratase
- L-serine dehydratase
- L-threonine dehydratase
- Tryptophan synthase beta chain-like PALP domain-containing protein
- L-threonine dehydratase
- Probable 2-hydroxyacid dehydrogenase
- Aldoketomutase
- Lactoylglutathione lyase
- Lactoylglutathione lyase
- Protein/nucleic acid deglycase HchA
Sequence:
MILGTPKADWLAEFPRLADLIALRPSEWFNPAIAPSAEALADVGLGAADVADASARLQRFAPLIARLFPETAASGGIIESDLVEVATFHDALRQHYAAELPGRLWLKRDSHLPISGSIKARGGIYEVLAHAERLALEHGLVGLDDDYSRLAEADCRAFFARHRIAVGSTGNLGLSIGIIGAALGFQASVHMSADARQWKKDKLRAHGVTVVEYASDYSVAVEQGRREAAGDPYTHFVDDENSRDLFLGYAVAAERLRGQLDAAGIRVDSEHPLFVHLPCGVGGGPGGVAFGLKLAFGDAVHCLFAEPTHSPCMFLGVYTGRHEQVSVQDFGIDNRTAADGLAVGRPSGFVGRAMQRLLDGYYTVDDDELFRLLALLERSQGIRLEPSALAGATGIARVTREPQGYRERMGLTSARLANATHLVWATGGGMVPETEMRAYLERGRSLLD
Protein: Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Histone H3-K79 methyltransferase) (F7CVL0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU271113}.
Interaction partners:
Sequence:
LERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASAERKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTQLHSPNPLLVAPTPPALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFGHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNGHAASYELCNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHPKESSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSEKGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSATLEKQTGASAHGAGGAGAGSRSLAVAPTGFYAGSVAISGALASSPAPLASGMESAVFDESSGPSSLFATMGSRSTPPQHPPLLSQSRNSGPASPAHQLTASPRLSVTTQGSLPDTSKGELPSDPAFSDPESEAKRRIVFSISVGASSKQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLSTGVSPKRRALPTVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGVFTHAVPSASAHPFGAGVGSGAVCSSATLGLSPLQAAASTSASSFQAAASVETRPPPPPPLLPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSAASLQPANASLSVKLASLPHKVSRPSFTVHHQPLPRLALAQAAPAAPQASTSGPSAVWVSLGMPPPYAAHLSGVKPR
Protein: ABC transporter G family member STR2 (EC 7.6.2.-) (Protein STUNTED ARBUSCULE 2) (A9YWR6)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Together with STR, required for arbuscule development in arbuscular mycorrhizal symbiosis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20453115}; Multi-pass membrane protein {ECO:0000255}. Note=Located in the peri-arbuscular membrane of arbuscular mycorrhiza (AM). {ECO:0000269|PubMed:20453115}.
Interaction partners:
- Protein VAPYRIN
- Glycerol-3-phosphate acyltransferase RAM2
- Protein NODULATION SIGNALING PATHWAY 2
- Protein CYCLOPS
Sequence:
MKTQGLELETVIDIKHKPVSFTGGLEFESLTYTVTKKKKVDGKWSNEDVDLLHDITGYAPKGCITAVMGPSGAGKSTLLDGLAGRIASGSLKGKVSLDGNSVNASLIKRTSAYIMQEDRLFPMLTVYETLMFAADFRLGPLSAVDKRQRVEKLIEQLGLSSSRNTYIGDEGTRGVSGGERRRVSIGVDIIHGPSLLFLDEPTSGLDSTSALSVIEKLHDIARNGSTVILTIHQPSSRIQLLLDHLIILARGQLMFQGSLKDVGHHLNRMGRKIPKGENPIENLIDVIQEYDQCDFVGVEVLAEFARTGMKPPLLSDMEEIISYTNSIAPSPSPLHRGSKYEEKSQDFSYSSQISRRSLNDEFDHSIRSPYNNTPMSWSASNSAAFLKFTPSRLKNENKVQKPPSHASPGIYTYSSEILPATPTPHSSDYVVDENDYLTPTNSSQEHLGPKFANSYIGETWILMRRNFTNIRRTPELFLSRLMVLTFMGVMMATMFHNPKNTLQGITNRLSFFIFTVCLFFFSSNDAVPAFIQERFIFIRETSHNAYRASCYTIASLITHMPFLALQALAYAAIVWFALELRGPFIYFFLVLFISLLSTNSFVVFVSSIVPNYILGYAAVIAFTALFFLFCGYFLSSEDIPLYWRWMNKVSTMTYPYEGLLMNEYQTNETFGSNDGVSITGFDILKSLHIGTEEIKKRNNVLIMLGWAVLYRILFYIILRFASKNQRS
Protein: Cytochrome c (P00004)
Organism: Equus caballus (Horse)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Interaction partners:
- Cytochrome c oxidase subunit 1
- Caspase-9
- Apoptotic peptidase activating factor 1
- Caspase-3
- Cytochrome c oxidase subunit 2
- Myoglobin
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Non-selective voltage-gated ion channel VDAC2
- Apoptosis regulator Bcl-2
Sequence:
MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE
Protein: F-box protein pof14 (Q10223)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9.
Subcellular location: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Associated with vesicle-like and endoplasmic reticulum (excluding a nuclear rim) structures.
Interaction partners:
- Squalene synthase
- Elongin-A
- F-box/WD repeat-containing protein pof1
Sequence:
MLQFSFQNCKTHTCYMNTSVNEHLDQDESFLRILIDTRKKIRSSYFKPQTFDEFVHCLARVRAMKRLVSICSNFDEEDNWNGVWNTLVVDGDSHASAMIDYEGLLDKCSLSRNLLELINDYAEYTTQVLPFRKIPSSDNLDSSLNLTVASPKSNLYYRYSSESPKYAKILDCPDEILQLIFSYCYDASYIEKLPFAFSYRKQRHTLIHDLPNTCLRFKKILSPRNVSFWKRLLKVHKKNPNSAVTCSESINTSAVAKFTDIPTIIPIFLDPSYQSYAAKTIHSDTSSLASSIIQTGDGTQSCDESTYIELACNLVGRCVLCNRIPKLTKFKDCITSFYRPSVATNICDQCLEAIIDFYEPVSRYKFDVMKDRLGVGYISRPGQKFPSWLSEHVQLARDEEKAFKSIYHSQGEFARSLFRLFRAQLAELCEQ