wanglab/gogpt-training-data huggingface dataset:
Protein: Putative gustatory receptor 28b (Q9VM08)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Transient receptor potential cation channel subfamily A member 1
- Gustatory and pheromone receptor 39a, isoform C
- Ionotropic receptor 21a
- Gustatory receptor for bitter taste 93a
- Gustatory and odorant receptor 21a
- Ionotropic receptor 25a
- Putative gustatory receptor 59c
- Putative gustatory receptor 36a
Sequence:
MDIEMAKEPVNPTDTPDIEVTPGLCQPLRRRFRRFVTAKQLYECLRPVFHVTYIHGLTSFYISCDTKTGKKAIKKTIFGYINGIMHIAMFVFAYSLTIYNNCESVASYFFRSRITYFGDLMQIVSGFIGVTVIYLTAFVPNHRLERCLQKFHTMDVQLQTVGVKIMYSKVLRFSYMVLISMFLVNVLFTGGTFSVLYSSEVAPTMALHFTFLIQHTVIAIAIALFSCFTYLVEMRLVMVNKVLKNLAHQWDTRSLKAVNQKQRSLQCLDSFSMYTIVTKDPAEIIQESMEIHHLICEAAATANKYFTYQLLTIISIAFLIIVFDAYYVLETLLGKSKRESKFKTVEFVTFFSCQMILYLIAIISIVEGSNRAIKKSEKTGGIVHSLLNKTKSAEVKEKLQQFSMQLMHLKINFTAAGLFNIDRTLYFTISGALTTYLIILLQFTSNSPNNGYGNGSSCCETFNNMTNHTL
Protein: Porin OmpL (P76773)
Organism: Escherichia coli (strain K12)
Function: Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:11080145}.
Interaction partners:
- Putative sulfoquinovose importer
- Putative 2,3-dihydroxypropane-1-sulfonate exporter
- Sulfofructosephosphate aldolase
- Sulfoquinovosidase
Sequence:
MKKINAIILLSSLTSASVFAGAYVENREAYNLASDQGEVMLRVGYNFDMGAGIMLTNTYNFQREDELKHGYNEIEGWYPLFKPTDKLTIQPGGLINDKSIGSGGAVYLDVNYKFVPWFNLTVRNRYNHNNYSSTDLSGELDNNDTYEIGTYWNFKITDKFSYTFEPHYFMRVNDFNSSNGKDHHWEITNTFRYRINEHWLPYFELRWLDRNVEPYHREQNQIRIGTKYFF
Protein: Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase 1) (Q8WZM3)
Organism: Candida tropicalis (Yeast)
Function: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11509667}.
Interaction partners:
Sequence:
MYSVLKQSIRPRLLATHNQFRTMITAQAVLYTQHGEPKDVLFTQSFEIDDDNLAPNEVIVKTLGSPVNPSDINQIQGVYPSKPAKTTGFGTTEPAAPCGNEGLFEVIKVGSNVSSLEAGDWVIPSHVNFGTWRTHALGNDDDFIKLPNPAQSKANGKPNGLTINQGATISVNPLTAYLMLTHYVKLTPGKDWFIQNGGTSAVGKYASQIGKLLNFNSISVIRDRPNLDEVVASLKELGATQVITEDQNNSREFGPTIKEWIKQSGGEAKLALNCVGGKSSTGIARKLNNNGLMLTYGGMSFQPVTIPTSLYIFKNFTSAGFWVTELLKNNKELKTSTLNQIIAWYEEGKLTDAKSIETLYDGTKPLHELYQDGVANSKDGKQLITY
Protein: Uncharacterized glycosyl hydrolase C11E10.09c (EC 3.2.1.-) (Q10427)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Probable glucoamylase
- Putative invertase
- Invertase
- Cell wall alpha-1,3-glucan synthase mok12
- Alpha-glucosidase
Sequence:
MNLICSILPKKEPSYLKLWRKQVIYQVLTDRFALDEDNFYAKASGNLYLGGTWKGITRNLDYIKSLGCTAIWISPIVKNISETTDCGQAYHGYWAQDMTQLNENFGTEEDLKELVNAIHEKNMLCMVDIVVNHMGHAGSKPVNFLLYQPFNSGKYYHNWQFVQNYDDPHETITGWLGDSHVNLPDIRTEKNEVRKFFQNWVSDLIKRYQFDGIRLDTAKHVEKSFFPTFIEAANVFTTGEVFHGDPKVVGDYQKYLPSTLNFPLFFQLRETFLDPKHSMFSFYDKAVLDVRHYFKDVTVLCNFLENHDFPRFFHETKDIALALNALTALIFMDGIPIIYYGQEQMFDGGSDPDNREGLWKSKYNTSNPMFRHLSSMIRTRQNLVETYPEFTYVLSFQLYIDDSVYVFTRPGVIIAISNEGSTSSFKVEIDLKEHWKEVPSSFTDILTQKTIPCKDHKLKIKSKSGLPKILISSDPSFL
Protein: Slowpoke 2, isoform N (A0A0B4KF87)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSMFFFRLHNLQRAEENKRKKRVEQQRQQQRQRRGAKVFKCVSDSTGHLTLAPSRLFERTPMSPSDSLDEIALQIPRVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATASENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNSRRKSNISFCSNINLGATCGPQMPQMNMNMANTAVGAGSRRGSGIAGLNPMQMQSVQTLAGYGSSSQRCSPPMQQIKSNSLSLPDSPTVVGNQRGRSNSLRIDNDILLRRSSSLRQGLPSVGVSHGRRKSSLEEIGISHFTTLMQATNHSNPIKISLNGSIGMENQISLQVTPPEEPTPMLGVPCMLGGGGGGGINPSGAGSSTGGMLGGGSSLAINTADLGPGPSTSSGASGSLQAQDSLGQQSSQVSSPQHLQGTIV
Protein: Sun domain-containing protein 1 (Q558Z2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:18266910, ECO:0000269|PubMed:19632001}; Single-pass membrane protein {ECO:0000269|PubMed:18266910, ECO:0000269|PubMed:19632001}; Nucleoplasmic side {ECO:0000269|PubMed:18266910, ECO:0000269|PubMed:19632001}.
Interaction partners:
- Lamin-like protein
- Kinesin-related protein 9
- Spindle pole body component 98
- Interaptin
- IST1-like protein
- Nucleoporin 210
- NKAP family protein
- Centrin-B
- Pre-mRNA-processing factor 19
- Brix domain-containing protein
Sequence:
MSGDYKPNYQSSPSRKRLPLQSKDQASIYKYQTPSTLNLYNNTVNNNSSNNSNNHLLHNSNPNSSYLYDSSKQYSNQINIRNNSNSNSNTNNITSKKASSSYSINNKVDHNSHNNNDDDDIEDDVDINYSTNNASSNILHNRFSNSNKDDSYIDYSTDENPKILKQPQPLYNHLNNQIQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQRNNNNNSNSSNNNNTSTTIKRNNQQIDNNSNKNIISKFIGDPWKNFYYGSNKSLWPFERNNNSNNSSNNNNKVNFKQAIWIFIFSVLFIGCLLGLFSTNFYGIHIYFPSFSTTKTNSPFNSTNNNIQFSNLITKEQLYPIIDEYFKKNEILKSYNKLFEKIENDIKYLSEREQYKDIINEIKEELKLVKLSNMDEDRVNQLISKMINHYNNNENNKQELKELLSKSIEELTKLKSDSKEQLIQISTESMNQLGQLKSESINQLGQVKSESIDKFQSTLKSLSKEEQSKIEREFNHQFNQLNKDADQLLSQHSLKIEKLREEINENQQSSLLKLTQEYKQLEERLKEFSSKLQQSISSSSMDQFESWKLVFIKDIEERINKESSKLTNQYIQLTQQFTKIQSFIKDNPSIDSLTNTIESLEGIKLLIEDILEVYSADKIAKVDYALGLAGASIEYNALHYRVSETYPPIKGSGSGSGSGGANGNSLGLYYYNLATNWIFPQPKPNPPETILDPMVNTGSCWGFYTGNGTIVIRLAKKIAITEVTMEHISSNISHHIDSAPKEFQVFGLINSSDIGQSLGVFTYDTTINRHLQTFKVNKIQSTTTTTTNQDQNDDDNIQEFSHVALRILSNHGYRYTCIYRFRVHGYQIPHPEQEQIQIIQEEQSFKQEEINQQQIEQIEQIEQIEKQQQSDEL
Protein: Myosin regulatory light chain 2, atrial isoform (MLC-2a) (MLC2a) (Myosin light chain 2a) (Myosin regulatory light chain 7) (Q9QVP4)
Organism: Mus musculus (Mouse)
Interaction partners:
- Actin, cytoplasmic 1
- Myosin-6
- Rho-associated protein kinase 2
- Natriuretic peptides A
- Actin, cytoplasmic 2
- Rho-associated protein kinase 1
- Troponin I, cardiac muscle
- Homeobox protein Nkx-2.5
- Troponin T, cardiac muscle
- Myosin-11
Sequence:
MASRKAGTRGKAAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCIDQNRDGIICKSDLKETYSQLGRVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTDPEEAILSAFRMFDPSGQGVVNKEEFKQLLMTQADKFSPAEVEQLFALTPMDLAGNIDYKSLCYIITHGDEKEE
Protein: Protein kinase A catalytic subunit isoform 1 (Q38DR5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase A regulatory subunit
- cAMP binding protein
- Cyclic nucleotide-binding domain-containing protein
Sequence:
MTTTPTGDGQLFTKPDTSGWKLSDFEMGDTLGTGSFGRVRIAKLKSRGEYYAIKCLKKHEILKMKQVQHLNQEKQILMELSHPFIVNMMCSFQDENRVYFVLEFVVGGEVFTHLRSAGRFPNDVAKFYHAELVLAFEYLHSKDIIYRDLKPENLLLDGKGHVKVTDFGFAKKVTDRTYTLCGTPEYLAPEVIQSKGHGKAVDWWTMGVLLYEFIAGHPPFFDETPIRTYEKILAGRLKFPNWFDERARDLVKGLLQTDHTKRLGTLKDGVADVKNHPFFRGANWEKLYGRHYNAPIAVKVKSPGDTSNFESYPESGDKGSPPLTPSQQVAFRGF
Protein: Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 (B1AR09)
Organism: Mus musculus (Mouse)
Interaction partners:
- Protein AF-10
- Protein AF-9
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Btk-PH-domain binding protein translocated to, 1)
- RNA polymerase II elongation factor ELL
- AF4/FMR2 family member 1
- AF4/FMR2 family member 4
Sequence:
MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGAGGGSSGGGGGGSSSASGGGGGTGGGSGNSFLSGRRSRSASPSTQPEKHPTHHEKGQKKSRKDKERLKQKHKKRPESPPSVLAPPAVPTADKVSSATSSSHHEASTQETSESSRDSKGRKSSSHSLSHKDKKLGTGKGSSLQSSPDFAAFPKLEQPEEDKYPKPADPTPPAPPSPTAPEPPKADLFEQKVVFSGFGPIMRFTTTASSSSRARAPSPGDYKSPHITGAGASAGTHKRMPALSATLGPAEEAPETTLKEKKHKASKRSRHGPGRPKGSRGKEGASGPTASLPAAQLAGFTATAASPFSGGSLVSAGLGGLASRTFGPSGSLPSLSLESSLLGAGIYTSNKDPISHGGGMLRAVCSTPLSSSLLGPTGTSALPRLSRSPFTSTLASSSASISTTQVFSLAGSTFSLPSSHIFGTPMGTVNPLLTQAESSHTEPDLEDCSFRCHGTSPQESLSSMSPISSLPALFDQTSAPCAGGQLDSTAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQVLNVQLSVPFPALPAALPATNGPIPGPYGLLPQAGSSDSLSVSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPGATGLGAMPMAEGLLGGLAGSGSLPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQMQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGSNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLPGADASGNGPKGGTADKGASTSQEKG
Protein: GTPase IMAP family member 8 (mGIMAP8) (Immune-associated nucleotide-binding protein 9) (IAN-9) (Immunity-associated protein 8) (Q75N62)
Organism: Mus musculus (Mouse)
Function: Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16088918}. Golgi apparatus {ECO:0000269|PubMed:16088918}. Mitochondrion {ECO:0000269|PubMed:16088918}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8ND71}.
Interaction partners:
- GTPase IMAP family member 6
- GTPase IMAP family member 1
- GTPase IMAP family member 4
- GTPase IMAP family member 9
Sequence:
MATSSHQGAAAGSQAEHRSCEASVGQGERPSASQGQEGNFKQNQGTSTLRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELLADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIESKESLKELIKNIGSRRCCTFNNKADKKQRELQVFKLLDAIELLMMESPEPYFEPLKMESSGVQGCGNGVTYEGDTLCGSKKRQPQITGPDCDPDMPELRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEKQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVKNHTFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKENDALYNLTQKFGERYAIFNYRASVEEEQSQVGKLLSQIEKMVQCHSNKPCVIREKELLNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTPGTEKDPSRLKEEIHHCLSLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTKNKALKKILKKCNGRVCAFNNKETGEDQETQVKGLLKIANSLKKNYDEHSNSWVGQLKSTLGQITMAFK
Protein: Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) (Q8JZR6)
Organism: Mus musculus (Mouse)
Function: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. Mediates sodium reabsorption in the renal cortical collecting ducts.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18359573, ECO:0000269|PubMed:21593314}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q2Y0W8}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:30355950}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to synaptic junction cell membrane. {ECO:0000269|PubMed:21593314}.
Interaction partners:
- Pendrin
Sequence:
MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIGVPSPKLQVPNVFKPTRDDRGWFINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN
Protein: Amino acid transporter, putative (Q381J0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSDKGKCATDVENTTSPVTQQTFPAEPSGVSKVSEPVYADDKNKRVDARGDAPPSVWQSFSAKMKHIAGTVVPYGGLASSVFNLCSVCIGAGFLGLPAAANRSGLVMAMLYLIIMALMTVFSLHILSLVMEKTGLRTFEHTARGVMGGRFVYFVIAIRLLNSFGTSTSYIITIGHVLRPIIENSCGAPEFLRTPGGIRLLTALTWMVFMLPLILPKRVNSLRYVSGFAIIFVLYFALTIVIHGAQSGLPKLTSDEEDGVKLFNSGNSAIASVGVFMFAYVCQINIYEVYWEMKKRSCARFTLYAAISMAFCGTFYGFVAFFGYGEFGGTVTNSILLMYNPITEVMMLIGSIGVVVKICISYALQTMAIRNSIYHVLGWELETLPYWKHFSFVIPLSLTVLLAGLFIPNINTVFGIVGAICGGFLSAIFPSLFYMYSGKWTRRNVGNFHFFGTYALFILGVVGLVFGTVTVVTNTIMSFIHGGGGAAVIKPPPVC
Protein: Cobalt/magnesium transport protein CorA (Q58439)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:10748031, ECO:0000305|PubMed:26051127, ECO:0000305|PubMed:9573171}; Multi-pass membrane protein {ECO:0000269|PubMed:23091000, ECO:0000269|PubMed:26051127}.
Interaction partners:
- Signal recognition particle 19 kDa protein
- Uncharacterized protein MJ1032
Sequence:
MITVIAIAKDGSIVEPKLDEISFEDYRLIWIDCYDPKDEELYKLSKKIGISVSDLQIGLDEQEIPRVEEDEDFYLIIYKAPLFEEDITTTSLGIYIKNNLLLTIHSDKIKAIGRLHKLISTKKPRIVFERGIGFLLYHILNEITRSYSRILMNLEDELEELEDKLLAGYDREVMEKILGLRKTLVYFHKSLIANRDVLVLLKRKYLPITTKEDRENFEDLYYDTLQLIDMSATYREVLTSMMDITLSLENIKMNQIMKILTMVTTIFAVPMWITGIYGMNFSYLPLANNPQGFWLVMALMVVIIMIFVYIFRRSGWI
Protein: Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) (P11166)
Organism: Homo sapiens (Human)
Function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:30197081}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:24847886, PubMed:25982116). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116}.
Interaction partners:
- Cellular tumor antigen p53
- Solute carrier family 2, facilitated glucose transporter member 4
- Solute carrier family 2, facilitated glucose transporter member 2
- Hypoxia-inducible factor 1-alpha
- Basigin
- Endothelial PAS domain-containing protein 1
- Stomatin
- Sodium/glucose cotransporter 1
- L-lactate dehydrogenase A chain
- Carbonic anhydrase 9
Sequence:
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
Protein: Histone deacetylase complex subunit CTI6 (CYC8-TUP1-interacting protein 6) (Transcriptional regulatory protein CTI6) (Q08923)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:12086626, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15133041}.
Interaction partners:
- Transcriptional regulatory protein PHO23
- Transcriptional regulatory protein RXT2
- Transcriptional regulatory protein UME1
- Transcriptional regulatory protein RXT3
- Transcriptional regulatory protein SDS3
- Histone deacetylase RPD3
- Transcriptional regulatory protein DEP1
- Transcriptional regulatory protein SIN3
- Transcriptional regulatory protein SAP30
- Transcriptional regulatory protein UME6
Sequence:
MESTAIVPKGPVVGSEDMEKAEVIASGSTDIISTTSTATTTAAIGSVQEESVKQEDVPMEGGEGEVEEEEGETRCICGELDTPDDSGFFIQCEQCSSWQHGYCVSITQDNAPDKYWCEQCRPELHQLFTTDTGEARSIYKPVQEKRRQSRRKARSAAASKSHAANEAEKSPRNTSNTDDNVDDIGDEEDEVEDEASAVALAKDGNTRSSRRRRRNSMDDASTDQYSLDPGDSDKKLLDRKRATFMAREEKQYQRMLEKALKESRRTSHQEDPESYENDADIYQGDTDNHNGTTRLQTDVMLTEGKPDSVTNDDMKESLRPSKEQSMEKTNDVEKEASQEKESSTGSAQDTEKTDEPILPLTSISSSEDDSRKASSRGSKRVSKPARKGNRTRRSNTSSDTNQNRRSADIGTDKPVKPRLPPQRTSLNEMRRRVSAILEFISRTQWELSEDQSDREEFVRFVENQHFVEKVDTIYNGYNESLSMMDDLTRELLLWEKKYSNNTNAIQ
Protein: Ufm1-specific protease (UfSP) (EC 3.4.22.-) (Odorant response abnormal protein 8) (Q94218)
Organism: Caenorhabditis elegans
Function: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins. Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23449979, ECO:0000269|PubMed:24603482}; Peripheral membrane protein {ECO:0000269|PubMed:24603482}. Cytoplasm {ECO:0000269|PubMed:24603482}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:23449979}. Note=Recruited to the endoplasmic reticulum upon interaction with odr-4. {ECO:0000269|PubMed:24603482}.
Interaction partners:
- Ubiquitin-fold modifier 1
- Ubiquitin-fold modifier-conjugating enzyme 1
- E3 UFM1-protein ligase 1 homolog
- Ubiquitin-like modifier-activating enzyme 5
- DDRGK domain-containing protein 1
- Odorant response abnormal protein 4
- ASC-1
- Serpentine receptor class r-10
- Serpentine receptor class r-10
- ApaG domain-containing protein
Sequence:
MTNSQTVSLIGPTQMAPQSTPPPPVNELWFIDAQAMFQNYANLRSFSKSNANEINTTIGGFVFGRKARKQVIHVLFAYAEDLTESNRQFLESSLSADIELVGNLNIDGQSQILPGGQFTLQLTSRMLENRSISEFLDMNVMFNNEHVLMEGASCVSRVGYEWSLRAGREQEDVKSAAERLSMASFRFTYLNAEHGLVIREQKPEAAQQKYLDKFSKGAVPYKDVIEFTAMQSLTRDTSNDTEDQKLVPTVKVTKDNKHFTRLVTIGEVVFPAFFGDSSLDLYKRSREAFNRRANNTMMVTVNGIRAGRGVTTTTSATYLPPGWVSLLHLQLPTKWTDNEQRNYRIRLHKLFNLPSSKPVLRLSQALALHSESARLTNKKLIREPHLSITNYQPVGEITTVNGPYNYHHYMQDGIDDSGWGCAYRSFQTIWSWFILNGYTDKPVPSHREIQQALVDIQDKQAKFVGSRQWIGSTEISFVLNELLKLECRFIATNSGAEVVERVRELARHFETSGTPVMIGGNMLAHTILGVDFNDTTGETKFLVLDPHYTGSEDIKTITSKGWCAWKPASFWSKDHFYNMVLPQPPSDAI
Protein: Protein mago nashi (P49028)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton.
Subcellular location: Nucleus {ECO:0000269|PubMed:12730685}. Cytoplasm {ECO:0000269|PubMed:12730685}. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.
Interaction partners:
- Eukaryotic initiation factor 4A-III
- Partner of Y14 and mago
- RNA-binding protein 8A
- Protein CASC3
- FI21285p1
- Importin-13
- LD40489p
- ATP-dependent RNA helicase WM6
- Eukaryotic initiation factor 4A
- Serine/arginine repetitive matrix protein 1
Sequence:
MSTEDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDTMIRKEAFVHQSVMEELKRIIIDSEIMQEDDLPWPPPDRVGRQELEIVIGDEHISFTTSKTGSLVDVNRSKDPEGLRCFYYLVQDLKCLVFSLIGLHFKIKPI