wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) (Q9CQR6)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (By similarity). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D13 During mitosis, regulates spindle positioning (By similarity). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity). Acts as a regulator of innate immunity by mediating dephosphorylation CGAS, STING1 and RIGI. Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (By similarity). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-420' impairs its ability to bind GTP, thereby inactivating it.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:O00743}. Cytoplasm {ECO:0000250|UniProtKB:O00743}.
Interaction partners:
- Serine/threonine-protein phosphatase 6 regulatory subunit 3
- Serine/threonine-protein phosphatase 6 regulatory subunit 1
- Immunoglobulin-binding protein 1
- Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
- Immunoglobulin-binding protein 1b
- Serine/threonine-protein phosphatase 6 regulatory subunit 2
- Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
- Serine/threonine-protein phosphatase 2A activator
- eIF-2-alpha kinase GCN2
- TIP41-like protein
Sequence:
MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
Protein: [histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356) (A0A8I6AHI4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLDDSRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (O18182)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
- Phospholipid-transporting ATPase
Sequence:
MSKKSVDVEASTSNSSSALYDTTVTKGHHRRTSSLWVPPTRPIFSSPTQVIKEKAENGGRILKTHPVTRWLFPTQPMLPQQRLVVPNNQKEPPPRYEQPNRKYCGNRISTTKYSVLTFIPKNLFEQLHRAANLYFIFIVILNMIIGAFGKYISVLPIAFVLGITAIKDAFEDYRRYKSDQKINHSTCRVWDASQQRYRKLEWQNILVGDFVHLSHDEIIPADILLLRSSDVNGVCYVETCNLDGESNLKQRQAIRSMGKYHNANVPLEYSPAEFNYRIACEQPTTDVYKFEGRLEAIEGGPPLAREFTILAKENVLLRGCVVKNTDFVEGIVLYAGKDTKAMLNNNGPRYKRSSLEKMTNVDILWSVCTLLALCVIGAVLSGVWLRTFSTPYIVPFLVFIHPNSSYHNNNDSQYKYSPSYESWFSFWSYIIVLQVMIPISLYVSIEFIKIFQVWFMSQDRNMYYDKVDKRLQCRALNITEELGQIQYVMSDKTGTLTENQMVFRRCSVNGNDYGGRPVVDAVDSSLELVASTLRSDQPTEKKLQMAALAEAAAKTRRLRPSRDPALESQLASSVLKLGADIDDPVFAFFLTMAICNTVVVNAKPHEDLMDPDGDIVNSRFAPEEVSPRRGSSLEDGFKYLADVEEESPASTQASTPVMITEENDGFEEIELIEFPEVKTDETQMTEKEETISAEVAAKKSGSDEKDNNYNGERKEGKGFGILHRPSILSVPFAKLKGMKSPFRRSVDKRSSSSTETAVAPPLHSFYDSESPDELALVEAAREYGIRLLRRRFDDVIVYLRHSTSSVKYKVLHTLPFDADRKRMSVIIRESSGLKRIIVLTKGADATVIPVLSEAFSTSARGEEVIFKSQEHLTQYAKEGLRTLCLSMKIWTEEEYQGWKEKHEEAELDMMDKETMLAESTLRAEQDLELLGVTAIEDRLQDGVPECIHSLREAGIRVWVLTGDKIETAVNIAYSSRLFSPSMDLLNIGANGVRAVSDLLTEHLKRIARAYEVSADAADSFGLVLNASTMSYCLDPHNLERFVKLLRGCRSVLCCRATPLQKAQLVNLAKNHLKGKVLAIGDGANDVSMIQGADVGIGLSGQEGMQAVMSSDFAMARFRFLSNLLLVHGHWNYYRLAQTILYFFYKNAMLVFVIFWYQIFNGFSAQVPIDPVYLMVYNLIFTSVPPLLFGCLDQDASAELLLDCPRLYEQGRLGKRYRWYSFWINMLDAVWQSLVVFFICYFTYRGSNVDMWTFGHLLVTQLIIVNTFHLALFVQYWTWPMFWSMFLSVLLFFICALLYNGFVTANWTWTNVKDPPSMVSLKSFSSLEFWMALIISVVLCLTPRYVLTTVVNTVSPSTTLRTRLGAEDGFKKKTESRFTACAVGCLSAPFKCARMCCQKTKPADVHIEEVHH
Protein: Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27) (P13635)
Organism: Rattus norvegicus (Rat)
Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense. involved in iron transport across the cell membrane (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1.
Subcellular location: Secreted {ECO:0000269|PubMed:14707133}. Note=Colocalizes with GCP1 in secretory intracellular compartments. {ECO:0000269|PubMed:14707133}.
Interaction partners:
- Ferroportin
- Heme oxygenase 1
- Ferrochelatase
- Heme oxygenase 2
- Copper-transporting ATPase 2
- Hephaestin
- Albumin
- Alpha-1-antiproteinase
- Alpha-2-macroglobulin
- Copper-transporting ATPase 1
Sequence:
MKFLLLSALLFLHSSLAWTREKHYYIGITEAVWDYASGSEEKELISVDTEQSNFYLRNGPDRIGRKYKKALYSEYTDGTFTKTIDKPAWLGFLGPVIKAEVGDKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLRANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHKEKEENIDQEFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHSELFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWMLSCQNLNHLKAGLQAFFQVRDCNKPSPDDDIQDRHVRHYYIAAEETIWDYAPSGTDTFTGENFTSLGSDSRVFFEQGATRIGGSYKKLVYREYTDDSFTNRKERGPDEEHLGILGPVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYGPDGRSSKQASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGLIGPMKICKKGSLLADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDEDFQESNKMHSMNGFMYGNLPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMTPDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDVTLYQGERTYYIAAVEVEWDYSPSRDWEMELHHLQEQNVSNAFLDKEEFFIGSKYKKVVYREFTDSTFREQVKRRAEEEHLGMLGPLIHADVGAKVKVVFKNMATRPYSIHAHGVKTKSSTVAPTLPGEVRTYIWQIPERSGAGTEDSPCIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKMEFSLLFLVFDENESWYLDDNINTYPDHPEKDNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGDEVNWYVMAMGNEIDLHTVHFHGHSFQYKHRGIHSSDVFDFFPGTYQTLEMFPQTPGTWLLHCHVTDHIHAGMVTTYTVLPNQETKSG
Protein: Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) (Q3UZ18)
Organism: Mus musculus (Mouse)
Function: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Subcellular location: Nucleus {ECO:0000269|PubMed:15606750}. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). {ECO:0000250}.
Interaction partners:
- Little elongation complex subunit 1
- Zinc finger CCCH domain-containing protein 8
- RNA polymerase II elongation factor ELL
- ELL-associated factor 1
- RNA polymerase II elongation factor ELL2
- RNA polymerase II elongation factor ELL3
- ELL-associated factor 2
- AF4/FMR2 family member 4
- AF4/FMR2 family member 1
- Cyclin-dependent kinase 9
Sequence:
MSSSITMSEPRLNWDVTPKNGLKAFFSPENYKDHSMAPSLKELYILSNRRIGENLSVSASSVENEPAVSSATQAKEKVGMILLPKPRVPYPRFSRFSQREQRTYVDLLAKYAKLPSSSKTVGTNTNEYLQYLDMKKHVNEEVNEFLKFLQNSAKKCAQDYNMLSDEARLFTEQLLRACIEQVKKYPEFYTLHEVTSLMGFFPFKTEMGLKLEKTLLVLGSAKFVKTAFPSMPVKLQLSKEDMSSIETPQQKAEVMHCDISKDPNAEKLVSRYHPQIALTSQALFTLLNNHGPSYKEQWEIPVCVEMIAVEGSKPVKVIYINSPLPRKQMTMRERNQIFHEVPLKHIISKNTSVPVSAVFMDKPEEYTSEVDMPTEAGECRKIETLENLDMDFDGDVTELETFGVTTTSPPRSPSSESDSSAPLMTDVHAVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATPNITDDSRSLCQILMKQLQKEKQLFSGVEGGPEGCKNKDDQGLEPCGEEVPSANAKSLTQDNEVHRTEGISKESDVGVLCTNDERQGGQGNANNPNNTATASEAAESEKGIPCGSDTDEDCLIIDTESRSCDGKTADLGSRPNSSAQASAGNQATTTVSEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPVSRKVPELPLTNSEESKQPPASEQPSAALDAAPWPKSSWPSAFQKPKGRLPYELQDYVEDTSEYIAPQEGNFVYKLFSLQDLLLLVRCSIQRVETRPRSKKRKKIRRQFPVYVLPKVEYQGCYGVEALTESELCRFWTESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYKTSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPPKPLRPAAQAKVGGTRMPTRNHRNPVSMETKSSCLPVQQVENEGVARNKRKIM
Protein: Protein PHTF1 (F1M8G0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12604659}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:12604659}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASNERDAISWYQKKIGAYDQQIWEKSIEQTQIKGFKNKPKKMGHIKPDLIDVDLIRGSTFAKAKPEIPWTSLTRKGLVRVVFFPLFSSWWIQVTSLRIFVWLLLLYLMQVTAIVLYLMMPIVSVSEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRKLRKTVNGDGTRDNGNNSPDKIRAVETLDSAPSVGGFWGTLFGNRIKRVKLVSNKGTETDNDSGCFHPIIKKRQGRPEIRMWQAREKAKVSDGEKCRREAYRRLGNGVSDDLSSEEDGEARTQMILLRRSVEGASSDNGCEVKNRKSILSRHLNSQVKKTATRWCHIVRDSDSLAESEFESAAFSQGSRSGMSGGSRSLNLSRRDSESTRHDSETEDMLWDDLLHGPECRSSVTSDSEGAHVNTLHSGTKRDPKEDVFQQNHLFWLQNSSPASERVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYEQGVGYQMLGNAVTIGLALFPFLYRLFREKSFDQLKSISAEEVLTLFCGAPPVTPVVILSIINFFERLCLTWIFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYLKRRGPQRSVDVVVSSVFLLTLSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLRLASLGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPFRLYGLTMNPLIYNITRVVILSAVSGVISDLLGFNIRLWKIKS
Protein: Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) (P15207)
Organism: Rattus norvegicus (Rat)
Function: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:9725910}. Cytoplasm {ECO:0000250|UniProtKB:P10275}. Note=Detected at the promoter of target genes. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. {ECO:0000250|UniProtKB:P10275}.
Interaction partners:
- Catenin beta-1
- E3 ubiquitin-protein ligase Mdm2
- Nuclear receptor coactivator 2
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Hepatocyte nuclear factor 3-alpha
- Nuclear receptor corepressor 1
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Endoplasmin
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQETSPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQQQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPSTGSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFSASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
Protein: [Ribosomal protein uS5]-alanine N-acetyltransferase (EC 2.3.1.267) (Acetylating enzyme for N-terminal of ribosomal protein S5) (P0A948)
Organism: Escherichia coli (strain K12)
Function: Acetylates the N-terminal alanine of ribosomal protein S5. Also plays a role in maturation of the 30S ribosomal subunit. Plays a role in the temperature regulation of pap pilin transcription.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- UPF0502 protein YceH
- Ribosomal-protein-serine acetyltransferase
- [Ribosomal protein bS18]-alanine N-acetyltransferase
- Putative oxidoreductase YceM
- Ribosome maturation factor RimM
- L-amino acid N-acetyltransferase AaaT
Sequence:
MFGYRSNVPKVRLTTDRLVVRLVHDRDAWRLADYYAENRHFLKPWEPVRDESHCYPSGWQARLGMINEFHKQGSAFYFGLFDPDEKEIIGVANFSNVVRGSFHACYLGYSIGQKWQGKGLMFEALTAAIRYMQRTQHIHRIMANYMPHNKRSGDLLARLGFEKEGYAKDYLLIDGQWRDHVLTALTTPDWTPGR
Protein: NADH dehydrogenase subunit 2 (Q2F9A4)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFNLFLAVSPEIFIINATFILLIHGVVFSTSKKDDYPPLVSNVGWLGLLSVLITLLLLAAGAPLLTIAHLFWNNFFRRDNFTYFCQILLLLSTAGTISMCFDSFEKERFDASEFIVLIPLPTRSMLLMIPAHDLIAMYLAIELQSLCFYVIAASKRKSEFSTEAGSKYLILGAFPSGILLFGCSMIYGSTGATHFDQLAKILTGYEITGAQSSGIFMGILFIAVGFLFKITAVPFHMWAPDIYEGSPTPVTAFLSIAPKISISANMSRVSIVASYGGTLQQIFFFCSIASMILGALAAMAQTKVKRPLAHSSIGHVGYIRTGFSCGTIEGIQSLLIGIFIYASMTIDAFAIVPALRQTRVKYIADLGALAKTNPILAMTFSITMFSYAGIPPLAGFCSKFYLFFAALGCGAYFLAPVGVVTSVIGCFYYIRLVKRMFFDRPRTWILYEPMDRDKSLLLAMTSSFITSSFPYPSPLFDLTHQMALSSYL
Protein: G-protein coupled receptor 62 (Q80UC6)
Organism: Mus musculus (Mouse)
Function: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9BZJ7}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q9BZJ7}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2 in the endosome. {ECO:0000250|UniProtKB:Q9BZJ7}.
Interaction partners:
Sequence:
MANGSGLSVTELAGSVGFILAVLVEVGAVLGNGTLLVVVLRTPDLQDAFYLAHLCVVDLLAAASIMPLGLLAAPPGLGTVPLDPSSCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGARPAPALVLTAVWSAAALLGALSLLGPPPAPPPAPARCSVLAGGLGPFRPLWAMLAFALPALLLLAAYGSIFLVARRAALRPPRGTRPRSDSLDSRLSFLPPLRPRLLGGKAALAPALAVGQFAACWLPYGCACLAPAARAAAAEATVTWVAYSAFAAHPFLYGLLQRPVRLALGRLTRRALPRAPKACTSQAWHLQTLLRRLQELRKDPVLGPSEAPEQARELARQTPSVSEAT
Protein: Peptidoglycan-recognition protein LC (Immune response deficient 7 protein) (Q9GNK5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns.
Subcellular location: Membrane {ECO:0000269|PubMed:11106397, ECO:0000269|PubMed:11872802, ECO:0000269|PubMed:22496930}; Single-pass type II membrane protein {ECO:0000269|PubMed:11106397, ECO:0000269|PubMed:11872802}.
Interaction partners:
- Poor Imd response upon knock-in, isoform A
- Protein immune deficiency
- Peptidoglycan-recognition protein LF
- Peptidoglycan-recognition protein LE
- Peptidoglycan-recognition protein LA
- Fas-associated death domain protein
- Peptidoglycan-recognition protein LD
- Nuclear factor NF-kappa-B p110 subunit
- Diptericin B
- Diptericin A
Sequence:
MPFSNETEMSQCSNAKRRVNDPLTGPKNCSTSSTDSGVILNDNVAAFRPEKETKDRGTGEGQFQSKSEEKTESKRISVEHTVNITTENVGKTSSPAVSIRSTTISVVSIDDNAIDSSSIDSDSEAEAEDYTVQKLGHQVTYPPNSSHLRDLNQGLTVISRHVAPGEAAVPPPNPLEAGIVAKQILNGNLAVATPTSPAGGATQGIGSIALTNSTDVTFGDKHFYEGPVTIQQFLIDNRDKWKPGEGPAGGQDNPAFNGGPSTNGSAPGSKHEDPAQTPPICPFLPNTVGRKAVTVTVVFVTLTFLLGIVLATTTNLFGKTLNQSKIRDDDDYRQNIPINSTIDLDNIGGGLILRFVERQQWLAQPPQKEIPDLELPVGLVIALPTNSENCSTQAICVLRVRLLQTYDIESSQKCDIAYNFLIGGDGNVYVGRGWNKMGAHMNNINYDSQSLSFAYIGSFKTIQPSAKQLSVTRLLLERGVKLGKIAPSYRFTASSKLMPSVTDFKADALYASFANWTHWS
Protein: Phosphoglycerate mutase (EC 5.4.2.11) (EC 5.4.2.4) (Q7T3G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphoglycerate kinase.
- Glucose-6-phosphate isomerase
- Glucose-6-phosphate isomerase
- phosphopyruvate hydratase
- Beta-enolase
- Glycerate kinase
- D-3-phosphoglycerate dehydrogenase
- Triosephosphate isomerase B
- Enolase 1a
- Triosephosphate isomerase A
Sequence:
MAAAHRLVIVRHGESSWNQENRFCGWFDADLSEKGLEEAKRGAQAIKDAGMKFDVCYTSVLKRAIKTLWTIMEGTDQMWVPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDKDHPYHKIISESRRYKGLKEGELPICESLKDTIARALPFWNEVIVPEIKAGKNVIIAAHGNSLRGIVKHLESMSDAAIMELNLPTGIPIVYELDKDLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK
Protein: Tyrosine-protein kinase receptor (EC 2.7.10.1) (G1K218)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MKSSSGGGSPTSLWGLLFFSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAASNNYIVGNKPPKECGDLCPGTMEEKPLCEKTTINNEYSYRCWTTNRCQKMCPSACGKRACTETHECCHPECLGSCSAPDNATACVACRHYYYAGVCVPSCPPNTYRFEGWRCVDRDFCANIPNAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNAIFVPRPERKRREVMQIANTTMSSRSRNTTVLDTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTTYENFIHLMIALPIAVLLIVGGLVIMLYVFHRKRNSSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSVKDEMEAGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSASLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
Protein: G-protein coupled receptors family 1 profile domain-containing protein (A0A0K3AYF5)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- FMRFamide-like neuropeptide 18
- G-protein coupled receptors family 1 profile domain-containing protein
- FMRFamide-like neuropeptides 1
- FMRFamide-like neuropeptide 21
- FMRF-Like Peptide
- FMRFamide peptide receptor frpr-18
- FMRFamide-like neuropeptides 14
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 7
Sequence:
MLLEIGTITIGNITRARKFGERMNGSDCLNLNSELWLYREDLSSRWYIMLVFAFLYLIIIAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPITAFKKEWIFGEALCRIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAFAATITSPIMFKQKLGEFENFCGQYCTENWGANESQRKIYGAALMFLQLVIPLTIIIISYTAISLKIGQSMILKGAKKQKTDNWEMELSDQQRIAVKRRQRTNRMLIGMVVAFACSWIWSVTFNILRDYEYLPELIKTQEYIFGIATHCIAMTSTVWNPLLYAVLNLQLRAAFIDLMPHWLRRHLNLEGDNSSPLLNHPTMTITNKYGSTATKTVKATYINTSNGQPYVSTSLVGKVQPEAPSFKFNGSGRKKSAMMRILVQKRNAEEEEQLITKESPSPPEIQMDTLCAASIIPRRKSAQPRSTNEKVVLPRKASF
Protein: Testis-expressed protein 22 (Testis-expressed protein of 22 kDa) (Q9D9U4)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12359214}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12359214}. Note=Localizes in the acrosomal region of early elongating spermatids. During late stages of elongating spermatids, no longer detected in the acrosomal region, while it mainly localizes in the cytoplasm. Incorporated into the midpiece of spermatids and is also present in the mitochondrial sheath of mature spermatozoa.
Interaction partners:
Sequence:
MDSRQQRPQRKTLQWQLAQEQRQQSPPQGLAVASSQPDTKSKPQDDLQTQDWVCEPQELRRPGSRWNISIDERRRLALQRMQERTDTARAPSGDPLGLHPEGQQTETSPSTQSVPTPPLQACETMADPLQDIAHVLAELMSEGVERDVLISQPLRSTENSNAFQDFLAQDAPLWKDENFEAQTSRWPHS
Protein: T. brucei spp.-specific protein (Q57U07)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTRYSLALCMVLSLVFAVVFLRPIAAAPQESNGSNTISVPPIDGDTMLLNQNVILFACIVDTPFTQFDADEFIEKALGILTQLPKGEFNRTSQFELLEYCSWDTRVADEKSFCGAEDEGPTYAAQTLVRFGVAGVDGESLKRLSFSSLSAILPPFIQGEDPALFPPDKRQHFVERMMNSDNTFDVVAVVVLFLYPILLFYYLLTSCTRERIRDKQCVEFLRNSINSELAYRQHMKCAEMYASSGQTVQKCGSDAYNVELEDMDPHNRVNVMSREGMASGEVACNDGRDGGMQKPTQL
Protein: Reduction in Cnn dots 1, isoform D (EC 3.-.-.-) (A0A0B4KEP1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSFFDCFNDFLQSGGNLVQNVSQEQEQKIADQELDGVIELMPPTTPTPSESSSTISAPSESSFSEKMEHSYMRDTPVRSDVHNGLTPARNILVRHPPQCPSCHTYPPQHEELSEIQQAHVPPYDEVVAKEAMNECARIAKYVKNNNSDEQDWVARVNKFNWTPMQEMVFEKVCSILDQDQLARLANDKRQHEPIHRRISSDKSASRFRKLLASVAWESRITQWIHALLMEHLSPSYMASYLEILQTLKTKLPTLVDKMLFGRPLNNSQELLAPVMKKRWEPNIMPKSRQLTHNAIMVVLPNMPTTGTVSDRMQKWYQALSTITQVVQISLPNTNNRIGNQNLDHVAETIVSITRVKINELRTENPSRGIILVGFNAGAALALQVALSESVACVVCMGFAYNTIRGPRGTPDDRMLDIKAPILFVIGQNSARTSQEEMEGLRERMQSESSLVVVGSADDALRVPKSKRRIEGVTQSMVDYMVVEEIFEFVNRTLSNPPGPRMPTCLMHQQGYQRLPKQSPHILADGNANKAVQQMRKRKMDGGLDDSMGQPSKTKFVPHNRVHKPKPPRLIDPFAVKRKVGRPRTRPLPNVGGSARSVSQKGAPHPDQPKLSGEEPNQSIEFILDDAQDYGDAQTTAGGSASLPKVITPGVLGKQLPPVNLAAGTKIKMIPSSQFVQIKSLPSQSKLINYTLNKPSVGTSSTANIGSVVKTLPCSSVSGQQIITLKTPSGQTQQFATAATSTGAAGSSTSTGTGQKKYTVFKNANGMTMLHLTKSVPTTGSSSGSANMDLSNIIDMPIVFADNEGNIPEHQQADKDIKPAPIRSANKSPLIISQKIIKEANKPSGMVTSGSITAVSKPGNIVLNKGLQQLLNSSPGGTLATQNKVVYLNRSTIKPMGNVAPGTHRVPIRIVSTPNTGGAVTTTASSSPIMVDPATGSKVAKTVNVQTIKPTGSVLAQGTIRQAGNVGTKSYLQMINTAPGASKTVAGDGKGSVRNIYFKSATGLKQLPVQMLGNRIPGGAVISSTASASSGSPGLRRVVNIGPVSKVTATSTTSSSIAATLTHNKM
Protein: CLE-1B protein (Collagen alpha-1(XVIII) chain) (G5EDV5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLLPRHHLGGLLYFCALYLLRASQAQPPTFFALNALPGDSETEVDLLAPVKASLNADARVFRAKGIESLPAIGLQRGVEIAVPYRLYLPRNFFKQFSLLATIKPMDKRGGYLFAAVNAYDSAVDIGLLIEPAGTKQTNISLIVRSVAIVSFLVEDFSQQWTQFALEVVDQTVTFYFKCRRFASRQVTSLPDFSFDEAEKLYIASAGPIIDNGFEGAIQELKLIDDATQGSRQCDEQWGAEGSGTPEEFKKTQESSELQKISDFPPTPAPPPPYPTPQLAPHDLRSYEQQAATTPFQGAPPSNQCTQVCRGEPGPQGPSGNDGIPGSHGAPGHQGERGADGAPGLHGSRGDQGLPGPPGMPGLAGPPGPPGSGTGHGSGADGPQGPPGLPGAPGRDGTSGVEGQRGPQGPPGPKGDDGVSMESLTDDDIERIARRVASIQKESNEPMRGDLPEYNSKVHSFTTKGEKGERGAPGAPGAPAPPAYGTLTTGTAVNVHATTVELFASARSTSVGQLAFATSSQQLFIRVTNGWKEIQLTHFHPFVETRHSTQNSRQNDASHAGRSRTGSAAAPWYPKANLDEPQRDAGVHNKDRVIHMIALSQPFSGNLHGLRGADLQCYREARAAGYTTTFRAMLSSNVQDLVRIVHSVDFDTTVVNVAGHHLFPSWRSFVNGAQMNPHAKLFSFDRHDVLNDSRWPDKRVWHGSKDGGIRAEQYCDGWRRADSSLTSLAGHISSNTSIFQSSGSEKCENKLVVLCVENMSKYHGDRILRLHRITSDFKK
Protein: XphA (Q9I2M8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004533}.
Interaction partners:
- Secretion protein XqhA
- Type II secretion system protein N
- Secretin XcpQ
- Type II secretion system protein GspC N-terminal domain-containing protein
Sequence:
MQRARLPESACCMSRHLPSSFVSLRSLAGHAPAVLCVLLLALLSASLASQTRSLRRELAELPAAAAPAPPANPSAAPRAALAGLFGGAPSPRGATAGERLQLRLLACFLARREDRSAALIAVAGRSQRFLPGAEVRPGTVLLAVHRDHVVLRDQGYEERLYFPKAEGAETTHATL