wanglab/gogpt-training-data huggingface dataset:
Protein: Rifin (Q8I4P5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFALPLNILIYNQRNHKSTTHHTLKIPITRLLCECELYTPANYDNDPQMKEVMDNFNRQTQQRFHEYDERMVEKRMQCKDKCDKEIQKIILKDKLEKQMEQQLTTLETKIDTNDIPTCVCEKSMTDKVEKGCLRCGRNLGVAVPGLGVLGAYGAHSIVKVAMATAEKVGIQLGIDAGNAAGIKAVIEALNSSLNIDNLGGITLDTVLKGNNFKNIDFLVYILTDKYNTTCTVSNTEVETLLCYIGKEKPTLPYTLIQSNVRKAVAEATEVATSTTEEMTTIYTTQELSKVTSTGAILSNPIIISFIVIVIVVIIFLIIYLILRYRRKKKTKKKLQYIKLLKE
Protein: Transcription factor E2-alpha (Transcription factor 3) (TCF-3) (Transcription factor XE12/XE47) (Q01978)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between tcf3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with tcf15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P15806}.
Interaction partners:
Sequence:
MNQQQRMTAVGTDKELSDLLDFSMMFPLPVANGKTRPTTLASTQFGGGSGLEERTGSAPWGTEDHNGSTFDQGRGYGDGTHYGEHRELPSHEGNLSAPFLASGLVGKNDRPPYSTFGRDSGMTMNQTGFLSGDLAMNSPSALSPNAGKAGSQYYTYPNNSRRRPGDSNLDAQPKKVRKVPPGLPSSVYPANSGDEYCGDRGSYASTKTPNSVYPGAFYMADGLHSSDIWASSGGIGQGGYSSVLNSSQSSVSQTTGFSSLHPHERMGFPMHSGEVNPSVTSSFSSTPAQYGVSSHTPPISTGDTIIGNRGTATGSSGDALGKALASIYSPDHSSTNFSSTPSTPVGSPQGITGSGQWPRANGPGALSPSYDGTLHTLQNKMEDRLDEAIHVLRSHAVGQTGALPGGHDDIHSLLSATASVLGSGFPAAVLSLANRHSMLNSHTEEALPSASNMLHSQVTVPAQPGSLPDLTRPQDSYSGLPGLGRAIPPGRVPDIKRESKEDEENRSVADLSDDEKKESKPQRSRTRCSINSQDEDEDEDDDNLPPEQKAEREKERRVANNARERLRVKDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVILSLEQQVRERNLNPKAACLKRREEEKVSGVDPQMGLSGGHPGVGDSHNPVGHM
Protein: Solute carrier organic anion transporter family member (Q961X2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362056}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362056}.
Interaction partners:
Sequence:
MLPAASGYSRERFTKDLPIKLLTLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQHEEEANNEKNTEI
Protein: EP1-like glycoprotein 4 (Curculin-like (Mannose-binding) lectin family protein) (Q9ZVA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000269|PubMed:23738689}. Secreted, cell wall {ECO:0000269|PubMed:18796151}.
Interaction partners:
- Tetratricopeptide repeat
- At4g30500
- Subtilisin-like protease SBT2.1
- Putative glucuronosyltransferase PGSIP8
- Zinc finger CCCH domain-containing protein 17
Sequence:
MEFSTTLALFFTLSIFLVGAQAKVPVDDQFRVVNEGGYTDYSPIEYNPDVRGFVPFSDNFRLCFYNTTQNAYTLALRIGNRAQESTLRWVWEANRGSPVKENATLTFGEDGNLVLAEADGRVVWQTNTANKGVVGIKILENGNMVIYDSNGKFVWQSFDSPTDTLLVGQSLKLNGQNKLVSRLSPSVNANGPYSLVMEAKKLVLYYTTNKTPKPIGYYEYEFFTKIAQLQSMTFQAVEDADTTWGLHMEGVDSGSQFNVSTFLSRPKHNATLSFLRLESDGNIRVWSYSTLATSTAWDVTYTAFTNDNTDGNDECRIPEHCLGFGLCKKGQCNACPSDIGLLGWDETCKIPSLASCDPKTFHYFKIEGADSFMTKYNGGSTTTESACGDKCTRDCKCLGFFYNRKSSRCWLGYELKTLTKTGDTSLVAYVKAPNASKKSALAI
Protein: b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) (P82251)
Organism: Homo sapiens (Human)
Function: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:12167606, ECO:0000269|PubMed:16609684}; Multi-pass membrane protein {ECO:0000269|PubMed:16609684, ECO:0000305|PubMed:12167606}. Cell membrane {ECO:0000269|PubMed:16825196, ECO:0000269|PubMed:32817565}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A1
- Amino acid transporter heavy chain SLC3A2
- Sodium-dependent neutral amino acid transporter B
- Autoimmune regulator
Sequence:
MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVVPPEEDPE
Protein: Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) (O15085)
Organism: Homo sapiens (Human)
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha-12
- Transforming protein RhoA
- Guanine nucleotide-binding protein subunit alpha-13
- Plexin-B1
- Plexin-B2
- Rho guanine nucleotide exchange factor 12
- Rho-related GTP-binding protein RhoC
- Rho guanine nucleotide exchange factor 1
- A-kinase anchor protein 13
- Excitatory amino acid transporter 4
Sequence:
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASPGP
Protein: ER membrane protein complex subunit 3 (Altered inheritance rate of mitochondria protein 27) (P36039)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:29809151}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P0I2}.
Interaction partners:
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 5
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 2
- Ubiquitin-conjugating enzyme E2 7
- Endoplasmic reticulum membrane protein complex subunit 10
- Protein SOP4
- Mitochondrial inner membrane protein OXA1
- Golgi to ER traffic protein 1
Sequence:
MLLDDQLKYWVLLPISIVMVLTGVLKQYIMTLITGSSANEAQPRVKLTEWQYLQWAQLLIGNGGNLSSDAFAAKKEFLVKDLTEERHLAKAKQQDGSQAGEVPNPFNDPSMSNAMMNMAKGNMASFIPQTIIMWWVNHFFAGFILMQLPFPLTAKFKEMLQTGIICQDLDVRWVSSISWYFISVLGLNPVYNLIGLNDQDMGIQAGIGGPQGPQGPPQSQVDKAMHAMANDLTIIQHETCLDNVEQRVLKQYM
Protein: Dof zinc finger protein DOF4.6 (AtDOF4.6) (Q8LAP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00071}.
Interaction partners:
- Transcription factor bHLH93
- AT3g15350/K7L4_15
- Protein EFFECTOR OF TRANSCRIPTION 2
- GATA transcription factor 7
Sequence:
MDTAQWPQEIVVKPLEEIVTNTCPKPQPQPLQPQQPPSVGGERKARPEKDQAVNCPRCNSTNTKFCYYNNYSLTQPRYFCKGCRRYWTEGGSLRNIPVGGGSRKNKRSHSSSSDISNNHSDSTQPATKKHLSDHHHHLMSMSQQGLTGQNPKFLETTQQDLNLGFSPHGMIRTNFTDLIHNIGNNTNKSNNNNNPLIVSSCSAMATSSLDLIRNNSNNGNSSNSSFMGFPVHNQDPASGGFSMQDHYKPCNTNTTLLGFSLDHHHNNGFHGGFQGGEEGGEGGDDVNGRHLFPFEDLKLPVSSSSATINVDINEHQKRGSGSDAAATSGGYWTGMLSGGSWC
Protein: DNA polymerase zeta processivity subunit (Revertibility protein 7) (Q0E7J8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA repair protein rev1
- DNA polymerase zeta catalytic subunit
- DNA polymerase subunit delta-2
- DNA polymerase delta catalytic subunit
- N-acetyltransferase eso1
- DNA polymerase kappa
- DNA polymerase alpha catalytic subunit
- Autophagy-related protein 101
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase delta subunit 3
Sequence:
MENDTGWSVKKCIDIFGEFLLVSIHCILYARRLYPQDLFIKARKYNTIVWQSRHPILCEYIEEVVQSCIEELQTGSVHQVALSIINKEQREEERYVFSTDSIPIIPDFLLEKQISTNEPFTDAYVEYMRASLIQLLNITNGLPLIEQECTWTLRVTLKDGFPRPKQWEEWFLPPQARETDATRQFKGITIPVRNVDIGPMMTEIWVEKYTNSD
Protein: Solute carrier family 2 member 6 (Solute carrier family 2, facilitated glucose transporter member 6) (F1RB41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- P3 protein precursor
- Solute carrier family 15 member 4
Sequence:
MADRSDEATPLINNSPPRISHGKLYLAVFSAVLGNFNFGFALVFPSPVIPQLKQGDDTRLQMNVHQISWFGSIFTLGAAAGGLSAMFLNDRVGRKISIMISGLPSVLGLLVMGSAQNFWMLLWGRFLTGIAGGITAGSIPVYVSEISHPSVRGALGSCPQITAVFGSLALYAFGLILPWRWLAVAGEVPVVIMMLLLCCMPTSPRYHIMKGNRAKAVKSLEWLRGPNSDYMTEFNKIERSITTQGVQWSDLKTKSYYKPILISVVMRFLQQMTGITPILVYLEPIFHLTAISLEPKYDAALVGAVRLISVAIAASLMDKAGRKALLFTSGFLIYIAMLSMTMYTHQTPCSQGNLTLTDGLNISSEVQAGAAFDPKTLIPLISAMVIIFGYAMGWGPITWLLMSEILPLGARGVASGLCVGVSWITAFVLTQLFMHVVVAYGLYVPFLFFCVVSVVNIIFTAKCVPETKGRTLEEIENYFRTGRSFTIHDP
Protein: Non-structural protein 1 (NS1) (B2BUF1)
Organism: Influenza A virus (A/Wyoming/03/2003(H3N2))
Subcellular location: Host nucleus {ECO:0000256|RuleBase:RU362113}. Host cytoplasm {ECO:0000256|RuleBase:RU362113}.
Interaction partners:
Sequence:
MDSNTVSSFQVDCFLWHIRKQVVDQELSDAPFLDRLRRDQRSLRGRGNTLGLDIKAATHVGKQIVEKILKEESDEALKMTMVSTPASRYITDMTIEELSRNWFMLMPKQKVEGPLCIRMDQAIMEKNIMLKANFSVIFDRLETIVLLRAFTEEGAIVGEISPLPSFPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKNLQRFAWRSSNENGGPPLTPKQKRKMARTARSKV
Protein: Succinate dehydrogenase assembly factor 3, mitochondrial (Q581U4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Translation initiation factor IF-2
- Uncharacterized protein
- Acyl carrier protein
- Uncharacterized protein
- Uncharacterized protein
- Dehydrogenase-like protein
- PROP1-like PPR domain-containing protein
- Uncharacterized protein
- Metallo-beta-lactamase domain-containing protein
- Mitochondrial SSU ribosomal protein
Sequence:
MNCSSTLACHAVVSAPSTASLITSCWTPQQHCYRQLMKSLRAAYFHDRSKLFWSRHRVLVEFYKYSEEANEEAVKQLVAIGLEVAAFIDHHMRTDVERIVKHNETMMALPVAQAKKFRSDYLLAEKQHDSWCKQKIKNIMKRRPPPPYPFF
Protein: Eukaryotic translation initiation factor 4 gamma 2 (H0YCH5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQISLRPAQSFLM
Protein: DNA polymerase alpha subunit B (O74946)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit pol1, an accessory subunit spb70/pol12 and two primase subunits, the catalytic subunit spp1/pri1 and the regulatory subunit spp2/pri2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:15314153}. Chromosome {ECO:0000269|PubMed:15314153}. Note=Present both in soluble and chromatin-bound form. {ECO:0000269|PubMed:15314153}.
Interaction partners:
- DNA polymerase alpha catalytic subunit
- DNA primase small subunit
- DNA primase large subunit
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase epsilon subunit B
- DNA polymerase delta catalytic subunit
- Uncharacterized RNA-binding protein C126.11c
- DNA polymerase zeta catalytic subunit
- DNA polymerase epsilon subunit D
- ATP-dependent DNA helicase pfh1
Sequence:
MEFPIDDEELLDERNKLLQICNMDEQTMFYKWESWCLQRGNTPKLDLDTFKAFAKDMKFQMERQVKATLKQNPERKSIKQIPGMNIDSILGLPVKTTASGDSLMQESKPSTETFELNSSDAGRVLEVLNKELKIVTSKPSAPSKLVIVANFDLKAFNYRIMYQKLYDSSEVLDDRIELFSALTCRKYNISDEDLANPSELTQEPVVVVGRIVVESTNLGGRLNQNSILLESSRRLGAGVRVRLKVDDLPSYSIFPGQIVSVKGSNPSGNMFIAKEILPIPPLPFPSSSKQEHATFVANTNNQPISIYIASGPWSLRDDLSFSPLKSMISYVNKNPVDLVILCGPFLDINHILIRTGNITGTSATSLEELFKERVTPILSQLTCPCILIPHINDAASDHPAWPQDAFNRVALGLPSNFKCFPNPCMFSINDVVFGVSTNDILLHTSREELFRLPSHGNLFARLVSHVLHQRHFYPLFPGGSLEKCNPSNLDIAHLKLGEFLNTMPDILILPSDLRYFVKNVENVVSLNPGKATKGINLGTFAKLTIAPLELGDNGSSNHYSHRVWLRTKAEILKL
Protein: Glutathione S transferase E5 (EC 2.5.1.18) (A1ZB70)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glutathione S transferase E6
- Glutathione S transferase E8, isoform A
- Glutathione S transferase E7
- Bifunctional glutamate/proline--tRNA ligase
- Uncharacterized protein, isoform C
- GH16740p
- Glutathione S transferase T2
- Glutathione S transferase O1
- FI01423p
- Glutathione S-transferase S1
Sequence:
MVKLTLYGVNPSPPVRAVKLTLAALQLPYEFVNVNISGQEQLSEEYLKKNPEHTVPTLEDDGNYIWDSHAIIAYLVSKYADSDALYPRDLLQRAVVDQRLHFETGVVFANGIKAITKPLFFNGLNRIPKERYDAIVEIYDFVETFLAGHDYIAGDQLTIADFSLISSITSLVAFVEIDRLKYPRIIEWVRRLEKLPYYEEANAKGARELETILKSTNFTFAT
Protein: Bruno 3, isoform H (M9MS36)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHIIELVGQPKVEFAQQVTMNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAFVKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSPYGAYAQLPSPPELQQQQQAALMAAAATAPGSAAAYMNPMAALATQIPHGLNGTGQPPSLPSPTMPNFNMGANTPNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLHLTIPPQGLPNGDAATLQHAFPGLPPFPGVAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY
Protein: HL04910p (Q95RZ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMLYTRSYVALPSENVAEIRVVLANRSATLYHMQKYQECLIDIKRALDLSYSKDLIYKLYERQARCYMALKDYPHTIDSFKKCITAMDDSTLASDKRAKLNLDAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPVACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGGYFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDACIDNWPKFDDLPRDVIRFRCDAPNNCSAVIEVPPSCNDFMVKCVTCGEITNILKGLKVMQDTEMMTRTAKRLYETGEYPKALAKFVDLIRIMYEVLAPPFPDFCESQQHLKDCFLNLGNVYTLD
Protein: Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) (Q8BFZ9)
Organism: Mus musculus (Mouse)
Function: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250}.
Interaction partners:
- Erlin-1
- E3 ubiquitin-protein ligase AMFR
- Transmembrane and ubiquitin-like domain-containing protein 1
- Protein sel-1 homolog 1
- E3 ubiquitin-protein ligase RNF170
- Protein OS-9
- Transitional endoplasmic reticulum ATPase
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- FAS-associated factor 2
- E3 ubiquitin-protein ligase RNF185
Sequence:
MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQFEGLSDDKLGFGLEDEPLEAPTKEN
Protein: Aryl-hydrocarbon-interacting protein-like 1 (F1T0B6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDAALLLNVEGVKKTILHGGTGELPNFITGSRVIFHFRTMKCDEERTVIDDSRQVGQPMHIIIGNMFKLEVWEILLTSMRVHEVAEFWCDTIHTGVYPILSRSLRQMAQGKDPTEWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLVFVIELLQVDAPSDYQRETWNLSNHEKMKAVPVLHGEGNRLFKLGRYEEASSKYQEAIICLRNLQTKEKPWEVQWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYVRARAHAEVWNEAEAKADLQKVLELEPSMQKAVRRELRLLENRMAEKQEEERLRCRNMLSQGATQPPAEPPTEPPAQSSTEPPAEPPTAPSAELSAGPPAEPATEPPPSPGHSLQH
Protein: Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) (Q9ERQ6)
Organism: Rattus norvegicus (Rat)
Function: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11929867}; Single-pass type I membrane protein {ECO:0000269|PubMed:11929867}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Cell surface {ECO:0000250|UniProtKB:Q71M36}. Secreted {ECO:0000250|UniProtKB:O95196}. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts (PubMed:11929867). {ECO:0000250|UniProtKB:Q71M36, ECO:0000269|PubMed:11929867}.
Interaction partners:
- Glypican-2
- Neuronal cell adhesion molecule
- Receptor-type tyrosine-protein phosphatase zeta
Sequence:
MGRAGGGGPGWGPPPVLLLLGVTLVLTAGAVPAREAGSAIEAEELVRSGLAWESRANDTREEAGLPAAGEDETSWTERGSELAAVGPGVGPEETLEASAAVTGTAWLEADGTGLGGVTAEAGSGDAQTLPATLQAPDEALGSSTMPPAIPEATEASGPPSPTLRDKPSLVPELPKEIPLEVWLNLGGSTPDPQRPEPTFPLQGTLETQPASDIIDIDYFEGLDSEGRGTDMGRFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLEEEEEEEEDKDAVGGGDLEDESDLLLPSQKPGVGPGTGQPTSRWHAVPPQHTLGMVPGGSISLRPRPGDPGKDLATSENGTECRVGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCDTPCVSSPHARALAHCDNIVCQDDPSAPHKIQEALKSRLKEEESFNIQNSMSPKLEGGKGDQDDLEVNCLQNNLT
Protein: Golgin candidate 4 (AtGC4) (Q8VYU6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:18182439}. Note=Probably located to cisternal rims of cis or medial Golgi.
Interaction partners:
- Golgin candidate 2
- Golgin candidate 5
- Golgin candidate 1
- Golgin candidate 6
- Golgin
Sequence:
MWSSVANLKENLNKIAHDVHDDDEDDDEDLTIYGSTNGGTDRRNSNGFRYSRSPMANGFESPVNPEIERYKAEINKLQKSESEIKALSVNYAALLKEKEDQISRLNQENGSLKQNLTSTNAALKESRLDLSRASNNNAIKGNGDHSPNRSQRSPTNWKNRNQMNNGIASKPNGTENDSESHKKEKEFAEMLEERTRSMASAQARELEKEREKSANLQILLQEERKQNETFKEELQSLRLDKEKTLMESNKVRRELDAKLAEIRQLQMKLNGGEQHAFGISRENLKEVNKALEKENNELKLKRSELEAALEASQKSTSRKLFPKSTEDLSRHLSSLDEEKAGTFPGKEDMEKSLQRLEKELEEARREKDKARQELKRLKQHLLEKETEESEKMDEDSRLIDELRQTNEYQRSQILGLEKALRQTMANQEEIKSSSDLEIRKSKGIIEDLNQKLANCLRTIDSKNVELLNLQTALGQYYAEIEAKEHFERELAVAKEDAMKLSARLKDVDEQLESSKKEKEEITSKVLHAENIAAEWKNRVSKVEDDNAKVRRVLEQSMTRLNRMSMDSDFLVDRRIVIKLLVTYFQRNHSREVLDLMVRMLGFSEEEKQRIGLAQQGAAGKGVVRGVLGFPGRLVGGILGGGGGSPDSHPNMASDNQSFADMWVEFLLKDAEERERREAEDAANKEQEKATVSSTQRPKYEQSDSEFSTVPLTSSNSNHRLSRLLT