wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein uS17 (30S ribosomal protein S17) (P0AG63)
Organism: Escherichia coli (strain K12)
Function: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. Also plays a role in translational accuracy; neamine-resistant ribosomes show reduced neamine-induced misreading in vitro.
Interaction partners:
- Large ribosomal subunit protein uL14
- DNA-directed RNA polymerase subunit alpha
- Large ribosomal subunit protein uL30
- GTP pyrophosphokinase
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS7
- Alternative ribosome-rescue factor A
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein bS6
- Large ribosomal subunit protein uL24
Sequence:
MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
Protein: Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3) (Q8IVF7)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21834987}. Cell membrane {ECO:0000269|PubMed:22275430}; Lipid-anchor {ECO:0000255}. Note=Enriched in lamellipodia.
Interaction partners:
- Rho-related GTP-binding protein RhoC
- Actin, alpha skeletal muscle
- Cell division control protein 42 homolog
- Rho-related GTP-binding protein RhoJ
- Protein diaphanous homolog 3
- Profilin-1
- Pre-mRNA-processing factor 40 homolog A
- Transforming protein RhoA
Sequence:
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
Protein: Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin) (Q9UMF0)
Organism: Homo sapiens (Human)
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin alpha-L
- Integrin beta-2
Sequence:
MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGGPEAAGGAAESPAEGEVFAIQLTSA
Protein: Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (HPK) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (P70218)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (By similarity). Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production.
Interaction partners:
- GRB2-related adaptor protein 2
- Mitogen-activated protein kinase kinase kinase 11
- C-Jun-amino-terminal kinase-interacting protein 1
- C-Jun-amino-terminal kinase-interacting protein 2
- Lymphocyte cytosolic protein 2
- Growth factor receptor-bound protein 2
- B-cell linker protein
Sequence:
MALVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLVSQPGLNRGLILDLLDKMKNPGKGLPVDIEDEEPEPPPAIPRRIRSTYRASSLGIPDADCCRRQMEFQRPRCVDCRPQAETVRLYPPAHFGSTSPRSQLSDSDDDYDDVDIPAPSENIPPPLPPKPKFRSPSDDGSGGIRDDGQLSPGVLVRCASGPPPRTPRPGPPPATCSPHLTARSDPSLWNPAAPEPGQPPLVPPRKEKMRGKMENEKRREKYPLLVKLFNGCPLQIHSTAAWTHPSTKDQNLLLGAEEGIFILNRNDQEATLEMIFPGRTTWLYCINNLLMSLSGKTPYLYSHSILGLLERKDGRTGSPIAHISPHRLLARKNMVSSKIQDTKGCRACCVAESASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLPVFTLLTTPGSELPAVCIGVSPGQAAKSVLFHTVRFGALSCWLDDSSTEHKGPVQVIQVKEDMVMVLMDGSLKLVTPEGAPAPGLRTPEIPMTEAVEAVAMVEDRLEAFWKHGVQVWAPGLKQPLQELRDPTLTFRLLCSPRPVVVETRPTDDPTAPSNLYIQE
Protein: Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) (P54296)
Organism: Homo sapiens (Human)
Function: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subcellular location: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
Interaction partners:
- Plasminogen
- Antiviral innate immune response receptor RIG-I
- Albumin
- TNF receptor-associated factor 3
- Fibronectin
- Serine/threonine-protein kinase TBK1
- Membrane cofactor protein
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Titin
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Sequence:
MSLVTVPFYQKRHRHFDQSYRNIQTRYLLDEYASKKRASTQASSQKSLSQRSSSQRASSQTSLGGTICRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQRFLSELAHLEEDVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFLFVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIAIYQDDLEGDAQVPGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYFIEKSVVGSGSWQRVNAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQTTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKEISAGVDEQGNIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKEDLGTYSVSVSDTDGVSSSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKGRVRFWLQAEHLSPDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFSIENEGTYTVQIHDGKAKSQSSLVLIGDAFKTVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETETLPNLERGICELLIPKLSKKDHGEYKATLKDDRGQDVSILEIAGKVYDDMILAMSRVCGKSASPLKVLCTPEGIRLQCFMKYFTDEMKVNWCHKDAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAFAEFQQFKAAAFAEKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKNKYGGEKIDVTVSVYKHGEKIPDMAPPQQAKPKLIPASASAAGQ
Protein: Fatty acid-binding protein, intestinal (B5X744)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- Fatty acid binding protein 6
- Gastrotropin-like
- hydroxymethylglutaryl-CoA lyase
Sequence:
MTYNGTWKVDHSENYEKFMEQMGVNMVKRKLATHDNLKITLEQTGDKFVVKEASTFRTLDMEFTLGVTFEYALADGTMLSGSWGMEGDMMKGTFTRKDNGKVLTTTRAIVGDELVQSYSYDGVEAKRIFKRG
Protein: NorF protein (Q51667)
Organism: Paracoccus denitrificans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDLTRIWLILLGLTGATTALAFVPGPVAAAALLAVALFKARAILGGFLHLERGSGWWAAFVVPLTIWLVLIWGLHVI
Protein: Global transcriptional regulator Spx (Redox-responsive transcription factor Spx) (Suppressor of clpP and clpX) (Spx) (O31602)
Organism: Bacillus subtilis (strain 168)
Function: Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator proteins and repress transcription. Exhibits no DNA-binding activity.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- ClpXP adapter protein SpxH
- DNA-directed RNA polymerase subunit alpha
- RNA polymerase sigma factor SigA
- DNA-directed RNA polymerase subunit beta'
- Putative acetyltransferase YjbC
- DNA-directed RNA polymerase subunit delta
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit epsilon
- DNA-directed RNA polymerase subunit beta
- Adapter protein MecA 1
Sequence:
MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRKVRSFQLREAQRLAN
Protein: PsbP domain-containing protein 4, chloroplastic (OEC23-like protein 5) (O49292)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}.
Interaction partners:
- PsbP domain-containing protein 5, chloroplastic
- Thylakoid lumenal 17.4 kDa protein, chloroplastic
- Probable inactive purple acid phosphatase 24
- UPF0603 protein At1g54780, chloroplastic
- Thylakoid lumenal 29 kDa protein, chloroplastic
- Probable inactive purple acid phosphatase 27
- Thioredoxin-like 1-1, chloroplastic
Sequence:
MMETALLRYCVNFSGHKKISAHQRSNSEIPKTSPGGCEDEWCARVLSRRSVMASGLVSSTTALAFPREGLAVVKQGLLAGRVPGLSEPDEEGWRTYRRPDEKSGGHGVGWSPIIPYAFSVPQDWNEVPVSIADLGGTEIDLRFASPKEGRLSVIVAPVLRFADNLGDDVKIENIGQPAKVINAFGPEVIGENVEGKVLSSNVAEHDGRLYYQFELEPPHVLITATAAGNRLYLFSVTGNGLQWKRHYKDLKRIASSFRIV
Protein: ICP27 (Q3MU88)
Organism: Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
Interaction partners:
Sequence:
MATDIDMLIDLGLDLSDSDLDEDPPEPAESRRDDLASDSSGECSSSDEDMEDPHGEDGPEPILDAARPAVRPSRPEDPGVPSTQTPRPTERQGPNDPQPAPHSVWSRLGARRPSCSPEQHGGKVARLQPPPTKAQPARGGRRGRRRGRGRGGPGAADGLSDPRRRAPRTNRNPGGPRPGAGWTDGPGAPHGEAWRGSEQPDPPGGPRTRGVRQAPPPLMTLAIAPPPADPRAPAPERKAPAADTIDATTRLVLRSISERAAVDRISESFGRSAQVMHDPFGGQPFPAANSPWAPVLADQGGPFDAETRRVSWETLVAHGPSLYRTFAGNPRAASTAKAMRDCVLRQENFIEALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLDNLATRLRPFLQCYLKARGLCGLDELCSRRRLADIKDIASFVFVILARLANRVERGVAEIDYATLGVGVGEKMHFYLPGACMAGLIEILDTHRQECSSRVCELTASHIVAPPYVHGKYFYCNSLF
Protein: TATA box-binding protein-like 2 (TBP-like 2) (TATA box-binding protein-related factor 3) (TBP-related factor 3) (Q5UE94)
Organism: Xenopus laevis (African clawed frog)
Function: TATA box-binding transcription factor. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Required for gastrulation. Regulates a large subset of genes that are ventrally expressed. Binds to a subset of promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:15345743}.
Interaction partners:
Sequence:
MDGESSLERYLDQCDAEDVLASSHMFTPMTPYDDLAIQPLPGTSYSSTLEHSKELSTDFSSVDLSFLPDDLNQENEDQQEQTPSQSLEHDSGICLDASNLSQPFTPSECRDATQDSSNLCTMPITPMTPMTPMTPVAESSGIVPQLQNIVSTVNLACKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKKTT
Protein: Fez family zinc finger protein 1 (Q0VDQ9)
Organism: Mus musculus (Mouse)
Function: Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDSSCLNATTKMLATAPARGNVMSTSKPLAFSIERIMARTPEPKALPVPHFLQGAVPKGDPKHSLHLNSSIPCMIPFVPVAYDTNSKAGVNGSEPRKASLEVPAPPAVAPSAPAFSCSDLLNCALSLKGDLARDALPLQQYKLVRPRVVNHSSFHAMGALCYLNRGDGPCHPAASVNIHPVASYFLSSPLHPQPKTYLAERNKLVVPAVEKLPSGVAFKDLSQAQLQHYMKESAQLLSEKIAFKTSDFSRGSPNAKPKVFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTHTRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQFKCNICNKAFHQVYNLTFHMHTHNDKKPFTCPTCGKGFCRNFDLKKHVRKLHDSSLGLTRTPTGEPSSDPPPQLQQPPPAPLPPLQPTLPPPGPLPSGLHQGHQ
Protein: T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) (P48643)
Organism: Homo sapiens (Human)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}.
Interaction partners:
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit zeta-2
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling 7
Sequence:
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
Protein: SmcR-like protein VvpR (Q7MHU7)
Organism: Vibrio vulnificus (strain YJ016)
Interaction partners:
Sequence:
MDSIAKRPRTRLSPLKRKQQLMEIALEVFARRGIGRGGHADIAEIAQVSVATVFNYFPTREDLVDEVLNHVVRQFSNFLSDNIDLDLHAKENIANITNAMIELVVQDNHWLKVWFEWSASTRDEVWPLFVTTNRTNQLLVQNMFIKAIERGEVCDQHNPEDLANLFHGICYSLFVQANRTNNTAELSKLVSSYLDMLCIYKREHE
Protein: BZIP domain-containing protein (A7T4J9)
Organism: Nematostella vectensis (Starlet sea anemone)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEEQFADPLDLSSLRDENVDKIYTYLFKSQEPSEADMELDSNSTSSSLSEGVTVDSRDISEVSSVGMQDLDSAVSSPENGMWGREVLGEGVVAYSCDASVVTIPKEQLVGLMNMALAVLSGLVQGSNKRPSSGDDTDGATPVKVSKMDLQREAEKRRKNNEASKRTREKRRNKEQELLKEKEIKEKENKALRTQVEDLEKQIKDIRSALDQRLTATS
Protein: Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) (Q9Y2W7)
Organism: Homo sapiens (Human)
Function: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18957440}. Cell membrane {ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:18957440}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:18957440}. Golgi apparatus {ECO:0000269|PubMed:11278424}. Nucleus {ECO:0000269|PubMed:21070824}. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:21070824}.
Interaction partners:
- Voltage-gated potassium channel KCNC1
- A-type voltage-gated potassium channel KCND2
- Presenilin-2
- A-type voltage-gated potassium channel KCND3
- Presenilin-1
- Battenin
- A-type voltage-gated potassium channel KCND1
- Transcriptional enhancer factor TEF-5
- Inactive dipeptidyl peptidase 10
Sequence:
MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
Protein: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (FP) (Q09508)
Organism: Caenorhabditis elegans
Function: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q0QF01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q0QF01}; Matrix side {ECO:0000250|UniProtKB:Q0QF01}.
Interaction partners:
- Putative succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Probable fumarate hydratase, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit
- Probable NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- Bifunctional glyoxylate cycle protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Uncharacterized protein F42A8.1
- Probable NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
Sequence:
MLRAASNGLRNTVAARSVSLSAANHSDAKRSDIAQYKVVDHAYDAVVVGAGGAGLRAAMGLAEGGLKTAVITKLFPTRSHTVAAQGGINAALGNMNPDNWRWHFYDTVKGSDWLGDQDAIHYMTREAERAVIELENYGMPFSRTTDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQYNCNYFVEYFALDLIMENGVCVGVIAMDLEDGTIHRFRSKNTVLATGGYGRAFFSCTSAHTCTGDGTALTARAGINNSDMEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSAGERFMERYAPNAKDLASRDVVSRSMTVEIMEGRGVGPDKDHIYLQLHHLPAEQLQQRLPGISETAMIFAGVDVTKEPIPVIPTVHYNMGGVPTNYKGQVLNYTPKKGDEVVPGLYAAGECGAHSVHGANRLGANSLLDLVIFGRACAIDILKNTSAGVGVPELPKNAGEASVANIDKLRHNKGDISTAELRLTMQKSMQNHAAVFRRGDILKEGVKVLSKLYKDQAHLNVADKGLVWNSDLIETLELQNLLINATQTIVAAENREESRGAHARDDFPDRLDELDYSKPLEGQTKKELKDHWRKHSIIRSNIETGEVSLDYRPVIDTTLDKSETDWVPPKVRSY
Protein: Syndecan (F1MP76)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
Interaction partners:
Sequence:
MDKGSEAQRWRSENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAMSTTPAVLPTMDIQPVGTPFEELPSERPTPEPATSPPLVTEVPEEPSQRATTVSTPTATTTATTTGPPTVATVPATVATAVPSIPAAPPSAATTSVVRTTGVRRLLPLPLTTAATARATTPAVPSPPTTVAVLDTEAPTPRLVSTATSRPRALPRPATTQKPDIPEKSTLPLGTTAPGPTEVAQTPTPESFLTTIRDEPEMPVSGGPSGDFELSEEETTQPDTANEVVAVGGAEAKPSPPPGTLPKGAHPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA
Protein: F-box only protein 5-A (Early mitotic inhibitor 1-A) (Q90Z80)
Organism: Xenopus laevis (African clawed frog)
Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activator cdc20 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:11389834, ECO:0000269|PubMed:17159919}. Cytoplasm {ECO:0000269|PubMed:11389834, ECO:0000269|PubMed:17159919}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11389834}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17159919}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11389834, PubMed:17159919). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:11389834). At metaphase, localized at mitotic centrosomes. Decreases centrosome localization as cells progressed through telophase (PubMed:17159919). {ECO:0000269|PubMed:11389834, ECO:0000269|PubMed:17159919}.
Interaction partners:
Sequence:
MMCGFASNQSPKKLSSKKSSATNVHLEISPVKHHPPCKVYENVQGSCLDSAICTTVAKCADLTDDLPVHNKENLLHRLNDLETNSYEEYSALQDSGYSSILQNDSPCQDETDRKVSDIQVRETPKNFMSYQRPFHTLSKINLPILRFEEAVCSTLKKMRKTNKKIDWNAVDVVCGGNYGLEHLIGKSMGLERFDILAELFHRDFKHLLTKILRHLSAMDLINVISVSTTWRKLLQKDNWAYNAYKLGCKELCEKRAKVSSHTATRDESLCRVPLASVQKVAASSLCTSKKQSKNKNGGLSCNRLAEFIEVAQTLKNDQSLKVCVDCGSPAKHDPCLHRAICTRESCKLDFCTRCSCKYHFSKSCLMSKPGSYRIPSEPLPGSKKSKQNLRRL
Protein: Eukaryotic translation initiation factor 4 gamma 1 (E7EUU4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPQAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Protein: Conserved protein (P95144)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative L-lactate dehydrogenase
- Diacylglycerol acyltransferase/mycolyltransferase Ag85A
- Endonuclease
- RNA polymerase-binding transcription factor CarD
- Elongation factor Tu
- Probable cold shock protein A
- Probable reductase
- ESAT-6-like protein EsxN
- Small ribosomal subunit protein bS1
- ESAT-6-like protein EsxO
Sequence:
MNAAMNLKREFVHRVQRFVVNPIGRQLPMTMLETIGRKTGQPRRTAVGGRVVDNQFWMVSEHGEHSDYVYNIKANPAVRVRIGGRWRSGTAYLLPDDDPRQRLRGLPRLNSAGVRAMGTDLLTIRVDLD