wanglab/gogpt-training-data huggingface dataset:
Protein: Flagellar protein FlhE (P76297)
Organism: Escherichia coli (strain K12)
Function: Not essential for flagellar formation and function.
Interaction partners:
- Flagellar biosynthetic protein FlhB
- Flagellar biosynthesis protein FlhA
- Peptidoglycan hydrolase FlgJ
- Flagellar biosynthetic protein FliP
- Flagellar protein FliO
- Flagellar FliJ protein
- Flagellar biosynthetic protein FliR
- Flagellar L-ring protein
- Flagellum-specific ATP synthase
- Flagellar motor switch protein FliG
Sequence:
MRTLLAILLFPLLVQAAGEGMWQASSVGITLNHRGESMSSAPLSTRQPASGLMTLVAWRYQLIGPTPSGLRVRLCSQSRCVELEGQSGTTVAFSGIAAAEPLRFIWEVPGGGRLIPPLKVQRNEVIVNYR
Protein: Nematode resistance protein-like HSPRO2 (AKINbetagamma-interacting protein 2) (Ortholog of sugar beet HS1 PRO-1 protein 2) (Protein Hs1pro-2) (O04203)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Positive regulator of basal resistance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17028154}.
Interaction partners:
- Poly polymerase
- At1g25400
- O-fucosyltransferase 20
- AT3g10020/T22K18_16
- F21O3.6 protein)
- At3g48450 family protein)
- Mitochondrial uncoupling protein 4
- Pollen Ole e 1 allergen and extensin family protein
- Uncharacterized methyltransferase At1g78140, chloroplastic
- At2g44240/F4I1.5
Sequence:
MVDMDWKRKMVSSDLPNSPKLSSKLHVTIPSPFKIVPVSSPISCSAPALCSAYELYLRLPELRKLWSSRDFPQWTSEPILKPALQALEISFRLVFAVCSDTRPYINHREWNRRLDSLITKQIQLVAAICEDEEEEGISAEAPVGGGRSSLSLLPQLATWRRSEALGKKILYTIDNEMSRCKYTLGLGEQNIAGKPNLRYDAICRPNEIYSLKDNPYADHIDNHENQTLYIIHQILESWIYASGNLLNRIVSSIEEEKFGKASNDVYLLEKIWKILAEIEDLHMLMDPEDFLKLKKQLQIKSTGKNDAFCFRSKGLVEMMKMSKDLRQKVPAVLAVEVDPTGGPRLQEAAMKLYARKTECDKIHLLQGMQAVEAAAKSFFFGYRQLVAAMMGSAEMNATASQESCDSLSQIFMEPTYFPSLDAAKTFLGEFWSHLG
Protein: Elongation factor 2 (B5X1W2)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Elongation factor 1-gamma
- Ubiquitin-like protein FUBI isoform X1
- 40S ribosomal protein S30
- 40S ribosomal protein S15
- 60S acidic ribosomal protein P0
- 60S acidic ribosomal protein P0
- 60S ribosomal protein L18
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein uL11
Sequence:
MVNFTVDQIRAIMDKKSNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSRAGETRFTDTRKDEQERCITIKSTAISMYYELSENDMAFIKQCKDGVGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEDLFQTFQRIVENVNVIIATYGEDESGPMGAIMIDPVIGTVGFGSGLHGWAFTLKQFAEMYVMKFAAKGDAQLGPAERCKKVEDMMKKLWGERFFDPATGKFSKSANGPDGKKLPRTFSQLVLDPIFKVFDAIMNFKKEETAKLIEKLDIKLDNEDKEKEGKPLLKAVMRRWLPAGEALLQMITIHLPSPVTAQKYRCELLYEGPGDDEAAMGIKNCDPKAPLMMYISKMVPTTDKGRFYAFGRVFSGCVSSGQKVRIMGPNFTPGKKEDLYLKPIQRTILMMGRYIEPIEDVPCGNIVGLVGVDQYLVKTGTITTFEQAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLYMKARPFPDGLAEDIEKGDVSARQELKVRARFLADKYEWDVSEARKIWCFGPDGTGPNLLMDVTKGVQYLNEIKDSVVAGFQWAVKEGALCEENMRAVRFDVHDVTLHTDAIHRGGGQIIPTARRVLYACQLTAQPRLMEPVYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVMGTPMFIVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILQGDPQDTSTKISQIVADTRKRKGLKEGIPALDNYLDKL
Protein: Glucosyl-3-phosphoglycerate phosphatase (EC 3.1.3.85) (Mannosyl-3-phosphoglycerate phosphatase) (EC 3.1.3.70) (P9WIC7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate, but GpgP also exhibits low dephosphorylation activity on mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3-phosphoglycerate (MGPG) in vitro. Shows only trace of phosphoglycerate mutase (PGM) activity.
Interaction partners:
- Diglucosylglycerate octanoyltransferase
- DegV domain-containing protein Rv2417c
- Conserved protein
- Glucosyl-3-phosphoglycerate synthase
- Ribosomal silencing factor RsfS
- Probable nicotinate-nucleotide adenylyltransferase
- Probable S-adenosylmethionine-dependent methyltransferase Rv3030
Sequence:
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHGGLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL
Protein: Oligodendrocyte transcription factor 3 (Oligo3) (Class B basic helix-loop-helix protein 7) (bHLHb7) (Oligodendrocyte-specific bHLH transcription factor 3) (Q6PFG8)
Organism: Mus musculus (Mouse)
Function: May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11091082, ECO:0000269|PubMed:11960707}.
Interaction partners:
Sequence:
MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHHQESRLNSVSSTQGDMVQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANAVHPVHPILGGALSSGNASSPLSATSLPTIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSAESKDLLK
Protein: Meiotic expression up-regulated protein 1/2 (Q9UTJ3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Meiotic expression up-regulated protein 23
- Meiotic expression up-regulated protein 18
Sequence:
MSIPANVLMEISFQELTSKKSEEYERKRLNEIGDLLTPQKIEEVLNCKDTKQRNVSLEDIFQDFLNFIITKNQEMFSMDCNSICKSYVLKVAEEKIEKLLKENGTLKNEEKCLRMQIVAQEEYVAPLIQKLEIIEKKLDKSFRKNMEDELRITRLASENNVLISRIDRTKRHFSELFTQKQMLQLQNENFKDDYEKIKEENKRLYKERKSFLSKIEKSACEIHDLKESDSFKDHEILRLKEERTAAMQAIDDISGTIETIKSDCYKVESENKGLINEVMDMRNFVQQLEQELYAFEDDYSRIQNDEELLKVGMIHLNKSENRTVEEMKIGDFGNTEEAKDVCVSDEDIHNVNIKQITTLIGKMSQVQIECKRLRKENLFLQSERTHLLRELEELRHLATSAKEDFVKVEKLNKIIKDENENLKEYIRNNSLSFQATAGELTQCKQLPQPRITGNDQENSHYTGAGNNCLELVGKENNCKNQYPQYFSNIDESNAFINNQCLELEALNRKNDLIRGELDSLKEKNLVAQKQLKSANNTLHVRAKHIQILENTNQSLKKNLENGRAEFRLKEIALIDLANQQIKNQDKTIHDLNTELCSLTLDYCNTAVERDTLRFRALEYLDHNKQTNPLPYHIVYMFSFETSPTVFQTSPEEDKENVNNIKISQPRNSLQTNGYIEGMANNVLDASFNVEDESHAISDSELGYFCEDQSNIYEVEDMRYYLFYTEEEKNMLPGFIVNARPANLDLFPCCYETTDKRSKHLKNMLNKKKLIKHIFHL
Protein: Protein rof (P0AFW8)
Organism: Escherichia coli (strain K12)
Function: Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination.
Interaction partners:
- UPF0253 protein YaeP
- Transcription termination factor Rho
- Uncharacterized protein YahJ
Sequence:
MNDTYQPINCDDYDNLELACQHHLMLTLELKDGEKLQAKASDLVSRKNVEYLVVEAAGETRELRLDKITSFSHPEIGTVVVSES
Protein: HD domain protein (Q727F2)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Bifunctional ligase/repressor BirA
Sequence:
MTQPFKDAISICKTILRNGYDAYVVNMRLQSELMAEDKRMEIDLACECDFDEIARLFPNATRSDEEGVLAMLEEGGVAHRFYLTDTEESSYPDRTLMRITPHMVARLQALGKAHSSLTLPYGAAAPHDSDDFESFDKGIIRLRGLPDETLRRNYLLAVRAIRYAANLDMEIDPVTWIAIVRSAGRVLDYVPVSDIVAEWQMVEAETMWKFVRLLFDAQLLHGLLPEVAALARVRQSRNDSGDTETVLDHTIECMRHYPEEGFHHDWYGTLAMLFHDVGKLFTADFHDGQWTFYQHHRVGAKVTRRLLHRLHLPAQEVDLICHLVRHHMRFHFMLTDKGIRRFAALDEYPRLMEMARADIKARDGSYTYFNHNQKYLERAATPEQMLEPLLNGNEIMQHTGLHPGPQVGLIRDALLNAQVTGAVADVNDAVAFIKEYKRQYFS
Protein: Cytochrome P450 703A2 (EC 1.14.14.130) (Laurate 7-monooxygenase) (Q7EZR4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in pollen exine and anther epicuticular layer development. Catalyzes the in-chain hydroxylation of lauric acid (C12:0) preferentially on position 7, generating 7-hydroxylated lauric acid. Does not possess activity with other fatty acids (C14:0, C16:0, C16:1, and C18:0). Participates in a conserved pathway of in-chain hydroxylation of lauric acid required for anther cuticle and pollen exine formation. Directly regulated by TDR, a known regulator of tapetum programmed cell death (PCD) and pollen exine formation.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- 4-coumarate--CoA ligase-like 9
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- 4-coumarate--CoA ligase
- Transcription factor UDT1
- Chalcone and stilbene synthases, N-terminal domain containing protein, expressed
Sequence:
MDPFLLSIILCSWIFVVVSWKKLNCMRRRLPPGPPRWPIFGNLLQLSPLPHKDFARFCTKYGPLVYLRLGTIDAITTDDPEVIREILIRQDEVFASRPRTLAAVHLAYGCGDVALAPLGPNWKRMRRVCMEHLLTTKRLESFAAHRALEAEHLCQFVWAKAQSGKPVNLREVLGAFSMNNVTRMLLGKQYFGLQSAGPGEAMEFMHITHELFWLLGLIYLGDYLPAWRWLDPYGCEKKMREVEKKVDDFHQKIIDEHRKAREAKKSASLDDDNKEDMDFVDVLLSLPGENGKEHMDDVEIKALMQDMIAAATDTSSVTNEWVMAEVIKNPRVLRKIQEELDGVVGRGRMVAESDLGQLTYLRCVVRESFRMHPAGPFLIPHESLKPTTIMGYDIPARTRIFINTHALGRNTRIWDDVDAFRPERHLPASADGGRVEISHLPDFKILPFSAGKRKCPGAPLGVILVLMALARLFHCFDWSPPDGLRPDDIDTQEVYGMTMPKAKPLVAVATPRLPPQMYGRHGKQV
Protein: Microtubule-associated protein 9 (Aster-associated protein) (Q3TRR0)
Organism: Mus musculus (Mouse)
Function: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity).
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis. {ECO:0000250}.
Interaction partners:
Sequence:
MSDEIFSTTLAYTKSPKATKRTSFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGEFSDTSTDESLVRKKMNDFHISDDEEKNSPRLSFLKTKKVNRAISNDALDSSTPGSEGSSPDAQEDVTGDSLPKSQNDDREVGREIITVKPTPRMHPVKRSTSSGETSSGLDADGHFKPSPQPRSMLKKSSHTEEGVRPGVDKEHSISEASAPTPSLPRQNGTELQTEEKIYSENLDLEDSLLQSLTSSSFKESPGGCTSPGSQEKVPIKDHDGEPTEIWDSLLSNENEGSSVLVNCVTPELEQPKDGQVAADDLEEEREKGGFTEDDLTTDPLLSTSPSVITPTEPAEPAKKANEDRNTKNKKTTNNRVSSASGRLMTSEFLKRSGPTKRSPSAATSSHYLGSLKVLDQKQPRKQSLEPDKADHIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKRIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKEKKLEYLKEKTRREKEYERAKKQKEEEAVAEKKKDSLTAFEKWSERKEALLKQKEKEKINERRKEELKRAEKKDKDKQAISEYEKWLEKKERQERIERKQKKRHSFLESETHPPWSPPSRTAPSKVF
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (Q8INJ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Tyrosine-protein kinase Src64B
- Focal adhesion kinase, isoform D
- Paxillin, isoform F
- DShc protein
- DE-cadherin
- Tyrosine-protein kinase Src42A
- Heat shock protein 83
- Breast cancer anti-estrogen resistance protein 1
- Cdc42 homolog
- Vinculin
Sequence:
MVTTIKITCDGVFIQSNSYLMPTPSPSGADATVSSSLERVLKPASASASPSNSNNESDNSQTSSGSQTASSASKRSNRSVGRSHRGSIAQDTRRRYYFGSKDIYWCKQSREAAAAATLSGSGLTRSASSVTHKEASTHATHTGGQVISRARRKPILLCSSLSAAYAPPRRREFYFCDKYAPGPARSTPTTTTTSATSAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIASSEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEGDLITVEIKQGLLRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNATA
Protein: RNA transcription, translation and transport factor protein (Q549M8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAIDWLLGLAVRLEYGDNAEKYKDLVPDNSKTADNATKNAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR
Protein: No long nerve cord, isoform F (EC 3.4.24.-) (X2JEX4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSVNMNWTSPKIWAALFVTTLCLLDTQAAWAKKLNASQAFDDTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGSCRGESTRYRICNMQPCPEQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQCRPRQPSYVGIPHVIAVMPGPWACVDFIATS
Protein: Transcription factor BTF3 (D6RDG3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKETIMNQEKLAKLQAQVRIGGKVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAPLATGEDDDDEVP
Protein: Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) (Q9QXZ7)
Organism: Mus musculus (Mouse)
Function: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15190009, ECO:0000269|PubMed:19186166}.
Interaction partners:
- Cone-rod homeobox protein
- Rhodopsin
- Recoverin
- Arrestin-C
- Homeobox protein OTX2
- Short-wave-sensitive opsin 1
- Neural retina-specific leucine zipper protein
- Peripherin-2
- Medium-wave-sensitive opsin 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Sequence:
MSSTVAASTMPVSVAASKKESPGRWGLGEDPTGVGPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSMAQVHLDAMETGSDPRSEPVVASPALAGPSPRGPTSVSATRAMGHHFMASLITAETCAKLEPEDAEENIDVTSNDPEFPASPCSLDGIHETSARLLFMAVKWAKNLPVFSNLPFRDQVILLEEAWNELFLLGAIQWSLPLDSCPLLAPPEASGSSQGRLALASAETRFLQETISRFRALAVDPTEFACLKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFLTAERIELLFFRKTIGNTPMEKLLCDMFKN
Protein: Magnetosome protein MamB (MM33.3) (Probable iron transporter MamB) (V6F510)
Organism: Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)
Function: Plays a dual, essential role in magnetosome formation; required for magnetosome vesicle formation as well as biomineralization (Probable). Requires heterodimerization with MamM for stability. Probably binds and transports iron (Probable). One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:22007638}; Multi-pass membrane protein {ECO:0000255}. Magnetosome membrane {ECO:0000269|PubMed:11571158, ECO:0000269|PubMed:14766587, ECO:0000269|PubMed:22007638}; Multi-pass membrane protein {ECO:0000255}. Note=Purified magnetosomes remain attached to each other (PubMed:11571158). Tagged protein has several locations; most is in 1-3 dots in the cell, also seen as patchy membrane localization, while about 20% localizes with magnetosomes in a straight line running through the center of the cell (PubMed:22007638). {ECO:0000269|PubMed:11571158, ECO:0000269|PubMed:22007638}.
Interaction partners:
- Magnetosome protein MamQ
- Magnetosome protein MamR
- Magnetosome protein MamT
- Probable membrane transporter protein MamO
- Protein p34
- Magnetosome protein MamN
- Actin-like protein MamK
- Magnetosome protein MamH
- Multi-heme protein MamP
- Magnetosome formation protease MamE
Sequence:
MKFENCRDCREEVVWWAFTADICMTLFKGILGLMSGSVALVADSLHSGADVVASGVTQLSLKISNKPADERYPFGYGNIQYISSAIVGSLLLIGASFLMYGSVVKLISGTYEAPSIFAALGASVTVIVNELMYRYQICVGNENNSPAIIANAWDNRSDAISSAAVMVGVIASVIGFPIADTIAAIGVSALVGHIGLELIGKAVHGLMDSSVDTELLQTAWQIATDTPLVHSIYFLRGRHVGEDVQFDIRLRVDPNLRIKDSSMVAEAVRQRIQDEIPHARDIRLFVSPAPAAVTVRV
Protein: Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) (P52565)
Organism: Homo sapiens (Human)
Function: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23434736}.
Interaction partners:
- Cell division control protein 42 homolog
- Transforming protein RhoA
- Ras-related C3 botulinum toxin substrate 1
- Ras-related C3 botulinum toxin substrate 2
- Tumor necrosis factor receptor superfamily member 16
- Rho-related GTP-binding protein RhoC
- Rho-related GTP-binding protein RhoG
- RAC-alpha serine/threonine-protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVVVTGLTLVCSSAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPVEEAPKGMLARGSYSIKSRFTDDDKTDHLSWEWNLTIKKDWKD
Protein: RNA polymerase sigma-54 factor (P49988)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Plays a role in the regulation of many virulence factors, motility, quorum sensing, mucoidy, a general mechanism for maintaining lytic phage in populations of bacteria, and biofilm formation. Positively controls the T6 secretion system by directly binding to the promoter regions of hcpA and hcpB genes, leading to their expression. Thereby, allows to colonize several hosts efficiently including mammals, insects, nematodes and plants (By similarity).
Interaction partners:
- Response regulator protein PilR
- DNA-binding transcriptional regulator NtrC)
- Transcriptional regulator FleQ
- Probable transcriptional regulator
- Sensor protein kinase PilS
- Response regulator protein FleR
- RNA polymerase sigma factor RpoD
- RNA polymerase sigma factor RpoS
- RNA polymerase sigma factor FliA
- Alginate biosynthesis transcriptional regulatory protein AlgB
Sequence:
MKPSLVLKMGQQLTMTPQLQQAIRLLQLSTLDLQQEIQEALESNPMLERQEDGDDFDNSDPLADGAEQAASAPQESPLQESATPSVESLDDDQWSERIPSELPVDTAWEDIYQTSASSLPSNDDDEWDFTARTSSGESLHSHLLWQVNLAPMSDTDRMIAVTIIDSINNDGYLEESLEEILAAIDPELDVELDEVEVVLRRIQQLEPAGIGARNLRECLLLQLRQLPSTTPWLNEALRLVSDYLDLLGGRDYSQLMRRMKLKEDELRQVIELIQCLHPRPGSQIESSEAEYIVPDVIVRKDNERWLVELNQEAMPRLRVNATYAGMVRRADSSADNTFMRNQLQEARWFIKSLQSRNETLMKVATQIVEHQRGFLDYGEEAMKPLVLHDIAEAVGMHESTISRVTTQKYMHTPRGIFELKYFFSSHVSTAEGGECSSTAIRAIIKKLVAAENAKKPLSDSKIAGLLEAQGIQVARRTVAKYRESLGIAPSSERKRLV
Protein: P25 protein (Brefeldin A resistance protein) (P30821)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Unknown. Target of pap1 transcription factor. Confers brefeldin A resistance in S.pombe.
Interaction partners:
- Uncharacterized oxidoreductase C663.08c
- Catalase
Sequence:
MSTANTVAIVIYSTYGHVVKLAEAEKAGIEKAGGKAVIYQFPETLSPEILEKMHAAPKPNYPVVTLDVLTQYDAFLFGYPTRYGTPPAQFRTFWDSTGGLWVQGALHGKYFGQFFSTGTLGGGQESTALTAMTSFVHHGMIFVPLGYKNTFSLMANVESIHGGSSWGAGSYAGADGSRNVSDDELEIARIQGETFFKTVFRK
Protein: Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (P35438)
Organism: Mus musculus (Mouse)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12008020, ECO:0000269|PubMed:1532151, ECO:0000269|PubMed:8060614}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35439}. Postsynaptic cell membrane {ECO:0000269|PubMed:36058615}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P35439}. Synaptic cell membrane {ECO:0000269|PubMed:26041915, ECO:0000269|PubMed:36058615}. Note=Synaptic cell membrane targeting is dependent of GRIN2B/GluN2B subunit (PubMed:26041915). Association with GRIN3A occurs in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P35439, ECO:0000269|PubMed:26041915}.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 3B
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2D
- Disks large homolog 4
- Glutamate receptor ionotropic, NMDA 3A
- Calmodulin-1
- Nitric oxide synthase 1
- Calmodulin 5
Sequence:
MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES