wanglab/gogpt-training-data huggingface dataset:
Protein: Putative inactive carboxylesterase 4 (Inactive carboxylesterase 1 pseudogene 1) (Placental carboxylesterase 3) (PCE-3) (Q9UKY3)
Organism: Homo sapiens (Human)
Function: Has no esterase activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MWLPALVLATLAASAAWAGHLSSPPLVDTLHGKVLGKFVSLEGFAQPVAVFLGIPFAKPPLGPLRFTLPQPAEPWNFVKNATSYPPMFTQDPKAGQLISELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSPGNWGHLDQLAALHWVQDNIASFGGNPGSVTIFGGSVGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEVGLRLVRLRLDTPTSLALCS
Protein: Tetraspanin (Q9V3E5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
Interaction partners:
- Uncharacterized protein, isoform N
Sequence:
MVFDCGVWCAKYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQLAYVLLVIGAVMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKNFLQTTITSYSLGENVDATSLMWNQLMGNFGCCGINDYHDFDASPAWVNGKGNRTIPDACCILKDVAKLVPRDEDCTTNPSDSNSFYKKGCYEVFTEWLIRQRELVIVAIAVGIVHLVLIILAFALCKAFAKYNDMRL
Protein: Fork head domain protein FKD2 (Hepatocyte nuclear factor 3-gamma) (O73778)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MLSSVKMESHEIPEWNPFYSEANEMYSSPSAMNSVSSLNSYINLNSACSTSSMNMGYPSAGLNSSPLSSMGGGPNHMSLSPVGSSLNPSSLTQLGSSASTLGPLSHYQSMGQPMSQISYPSPTSLNRTKEMPKPYRRSLTHAKPPYSYISLITMAIQQSQSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPNSGNMFENGCYLRRQKRFKIEEKAGKKSSSKSQDGSSTKGTHSSEGMQEEHSPTTGSDGAESAHSDSSHAGSTSEEQQRSLVQLDCPSQAPNLLHSSPVPIPSSVSASMPPSSSHLHSQGMGNSPHLLGSPMHHLDLQNDPLKSMDPHFNFNHPFSITNLMSNEQKMDLKSYQDQVMAYNSYATSSPVAAKQIYDNAGPSAIDSGAYYQTLYSRSVLNAS
Protein: Uncharacterized protein (A0A384KVW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGACASRESRRTETAKLILPDGTLQEFSTPVKVWQILQKNPTSFVCNSDDMDFDDAVLAVPGSEDLRPGELYFVLPLTWLNHPLRADEMAALAVKASSALAKSGGGGLSYNDEDVGECRVRRVKRNGCGGRGCGGGGKGRRKFTAELSSIAE
Protein: Calcium channel YVC1 (TRP homolog) (Yeast vacuolar conductance protein 1) (Q12324)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for release of calcium ions from the vacuole in response to hyperosmotic shock.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:11427713, ECO:0000269|PubMed:11781332}; Multi-pass membrane protein {ECO:0000269|PubMed:11427713, ECO:0000269|PubMed:11781332}.
Interaction partners:
- Calcium-channel protein CCH1
- Endoplasmic reticulum transmembrane helix translocase
- Calcium-transporting ATPase 2
- Stretch-activated cation channel MID1
- Vacuolar calcium ion transporter
- ATP-dependent RNA helicase DHH1
- Protein ECM7
- Calmodulin
- Calcium-transporting ATPase 1
- Polyphosphoinositide phosphatase
Sequence:
MVSANGDLHLPISNEQCMPENNGSLGFEAPTPRQILRVTLNLKYLIDKVVPIVYDPNDIVCDHSEILSPKVVKLAYEACGGNPKDKANKRKYQSVIIFSLLKVCEWYSILATMEVHNAKLYETRNLASQQLCKLLIEREETRDLQFLFMQLLLRRYVINENDEDQEPLNALELATDMHCTTVIGSSGFQRCLKWIWRGWIVQNGLDPTTFIKDDSLAEVSLISHFNPVRLKAPVYQNYLQMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAHLSFWNLFNDTTYLIITFAMGFRAMSVTPLNAKYSSEDWDKISYRVLSCAAPFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGLDSADGKRDITGPILGNLTITVLGLGSFDVFEEFAPPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIRAPDEDVYVSPLNLIEVFMTPIFRILPPKRAKDLSYTVMTIVYSPFLLLISVKETREARRIKYNRMKRLNDDANEYDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQRTAEQEDVHFKVPKKWYKNVKKCSPSFEQYDNDDTEDDAGEDKDEVKELTKKVENLTAVITDLLEKLDIKDKKE
Protein: Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) (P06400)
Organism: Homo sapiens (Human)
Function: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:20940255}. Cytoplasm {ECO:0000250|UniProtKB:P13405}. Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization (PubMed:20940255). Localizes to the cytoplasm when hyperphosphorylated (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000269|PubMed:20940255}.
Interaction partners:
- Transcription factor E2F1
- Transcription factor E2F2
- E3 ubiquitin-protein ligase Mdm2
- Transcription factor E2F4
- Cyclin-dependent kinase 2
- Transcription factor Dp-1
- Histone deacetylase 1
- Cyclin-dependent kinase 4
- Cyclin-A2
- G1/S-specific cyclin-D1
Sequence:
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
Protein: Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1b) (FLK-1b) (Kinase insert domain receptor) (Kinase insert domain receptor-B) (Protein-tyrosine kinase receptor flk-1b) (Vascular endothelial growth factor receptor 2 homolog B) (VEGFR-2 homolog B) (Q5GIT4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35968}.
Interaction partners:
- Vascular endothelial growth factor C
- Vascular endothelial growth factor A-A
- Neuropilin-1a
- C-fos induced growth factor
- Neuropilin 1b.
- Vascular endothelial growth factor Ab
- Protein tyrosine kinase 2ab
- Cadherin 5
- Paxillin
- Paxillin
Sequence:
MAKTSYALLLLDILLTFNVAKAIELRFVPDPPTLNITEKTIKINASDTLQITCRGRQILEWSTPHNRTSSETRLTISDCSGDGLFCSTLTLSKAVANETGEYRCFYKSLPKEDGKTSVAVYVFIQDYRTPFVRIAQDYDVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELSTDGKEVIWDSRRGFILPSRVVSYAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHTELNVGIDFQWTFPHEKRSVNGSMSTSRYKTSSNKKKLWNSLELSNTLTVENVTLNDTGEYICTASSGQMQKIAQASLIVYEKPFIALSDQLWQTVEAKAGDAEAKILVKYYAYPEPAVRWYKNDQLIVLRDEYRMKFYRGVHLTIYGVTEKDAGNYTVVMTNKITKEEQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTASGGSSPVTIKWQWMPREDCPVRFLPKSDTRMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIATNKMGQDQRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLRWYRVANVANHDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQGLYACQVEIVGTNEKTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGSGVILKRSNRVLTIQRVKKEDSGLYICTACNQQGCESSEARISVDGAEEKMNVELIMPIGAVVIAMFLWLLIVFVIRNRKRPNDGDLKTGYLSIILDSDDMPMDEHCERLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTYKTLQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDYIPLTNGEMEEELVAPHLNVTSKRSFYAGNTEAQLHYDNAPPLGFPQQMNSSGVPVNMTGFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESLASESSNQTSGYQSGYHSDDAEAPIYANEEMILKRDIRKKPPLPKRNDKFSAEVRYSAPPV
Protein: Probable betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) (Meiotic expression up-regulated protein 8) (O59808)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTIDLNVIQSDIISARRAPENSLFIDGKFVSPIEPAAKPIPLINPATEEIIGTCANASAKDVDSAVENAYNTFRSGIWAKWPGKQRGLVLRKIAKMMREKRELLAGIDTINCGKPTPYALFDIDSCADMFEYYAEVAETDNPTVKVPLPNNPGFCAFEKRFPRGVIGVITPWNFPLKMALWKLVPAIASGNCVVLKPSELAPWSCLEFALICKEAGLPDGVLNVIIGSGKESGAALSCHPKIAYLAFTGSLATGKKIMHAAAENIVPLTLELGGKSPLIICEDADLSLAIPSAAFAIFFNQGEACTAASRLIVHESVADEVLGGLVSEANKLIIGNGLDPQVTLGPVVSKTQFEKIVSYIQSAINEGCKCVVGGLPRSEQKGYFIPPTVFTNVQTHNKIWREEIFGPVLAVKTFHTNEEALELANDSEYGLGSGVFSTNPKTLEFFSNNIEAGMCSLNNYHVVTHELPWIGWKHSGLGVGLSKHGYNEYMRLKQITQYVG
Protein: Radixin isoform (T1SRT4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLRQIEEQTMKAQKGCIIKVLMVYIQKKKH
Protein: MYCL proto-oncogene, bHLH transcription factor (E9PQS5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDYDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPPWGLGPGAGDPAPGIGPPEPWPGGCTGDEAESRGHSKGWGRNYASIIRRDCMWSGFS
Protein: Protein lag-3 (Abnormal cell lineage protein 3) (Abnormal germline proliferation protein 3) (Q09260)
Organism: Caenorhabditis elegans
Function: glp-1/Notch and lin-12/Notch proteins promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator, probably as part of a complex with a Notch intracellular domain (NICD) and the transcription regulator lag-1. Involved in the p53-mediated germ-cell apoptotic response to DNA damage, perhaps acting as a transcriptional activator. May regulate phosphatase lip-1 mRNA transcription downstream of glp-1.
Subcellular location: Nucleus {ECO:0000269|PubMed:10884418}.
Interaction partners:
- Suppressor of hairless protein homolog
- Protein lin-12
- Anterior pharynx in excess protein 1
- Protein lag-2
- Putative transcription factor sel-7
Sequence:
MDDLSEFFVIEEMFISEPSVAGMKPSTSKTTHSPPPEEPTAPFVNDNLPNPEDEPTIGDLNAFHSGEELHRQRSELARANYEKARPEMIANQRAVTAHLFNRYTEDEERKRVEQQKNKEAMNASTSAPTSSRNGGQSVENRKRRNDVVVAPPTSEEEWKRAQQQHWMGQQQPQMQFQMQQQYHSQQQQYIMMQQQHHHMTGMQQIHHQMPSTSSADSIRSVPTPASSMHQPSPAEMRNGCGMSRNATMDMTCSPMSGGQPIVDENNLAVPEGEWFDKLALAVAEQYNVDTILGPDTYDTFLAELDFSSSESPTKQSPMEMNGDRMPSTAPPPAQNPQHIAQLQQQQNKMRLMQQQQQEMQRIEQQRRQQIMQQQQQQQQQEHQRQQMLLQQQQQQQQMQQHHQMNGGGQFATQAHQQAAYMQQMQRMEQIRHQQQQAQQHQQAQQQHQQQAQHHQMGYGIPNGYPQQMHMHPPAYGAHHMPQPTAFANIN
Protein: GPI-anchored micronemal antigen (Q8IBB9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Gametocyte-specific protein
Sequence:
MKYYTSLYVALIIALCQAVSALIRNSNTPQAFLIPELNNNEKNEFNNNEKNEMNNNLNNEFNNNEENCDIQKIAEEMMENLLNENDMYTNIMLSLQNRLSDDYLCSEPKYENICIHEKDKISLSFPCSNPKYEKLIHKFTFKKLCNSKAAFNNTLLKSFIEEDEEQNTFSLMLKQFKILLTCVDDELKDIYKESIDLLVDLKTSITELTQKLWSGKMVNVLKKREFLITGILCELRNGNKSPLISKSLEFENLGILKMNNEELLNEAYNAFSDYYYFFPYFIQKLLEKGGMIERLIKIHENLTKYRTKDMVNKINAQSKGEVLNNEDILNKLNAYKHYTKHGATSFIQSREVKIVNQNVNNDDTTKNQQQNVNNNEKLNNNNNNNNNQQVNNNNNNNNQQVNNNNNNNNNQVNNNNNNNNNQVNNNNYNNNNQVNNNNNNNQQVNNNNNYNNQLNNNNFNNNLQVNKNDKHVPKNNHTTATHTNNILYNPLYSINPEKPKDIIKLLKDLIKYLHIVKFENNEPTTNIDEEGIRKLLENSFFDLNDDILIVRLLLKPQTVILTVIQSFMLMTPSPSRDAKAYCKKALINDQLVPTNDTNILSEENELVNNFSTKYVLIYEKMKLQELKEMEESKLKMKYSKTNLSALQVTNPQNNKDKNDASNKNNNPNNSSTPLIAVVTDLSGEKTEDIINNNVDIATLSVGVQNTFQGPNAKAGSLINHLSYATFLFFSFILINLLN
Protein: Heat shock protein 23 (P02516)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heat shock protein 26
- Heat shock protein 67B3
- Heat shock protein 68
- Heat shock protein 83
- Heat shock protein 27
- Major heat shock 70 kDa protein Aa
- Major heat shock 70 kDa protein Ba
- Heat shock factor protein
- Major heat shock 70 kDa protein Bbb
- MAP kinase-activated protein kinase 2
Sequence:
MANIPLLLSLADDLGRMSMVPFYEPYYCQRQRNPYLALVGPMEQQLRQLEKQVGASSGSSGAVSKIGKDGFQVCMDVSHFKPSELVVKVQDNSVLVEGNHEEREDDHGFITRHFVRRYALPPGYEADKVASTLSSDGVLTIKVPKPPAIEDKGNERIVQIQQVGPAHLNVKENPKEAVEQDNGNDK
Protein: Nostrin, isoform H (X2JAX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cdc42-interacting protein 4, isoform B
Sequence:
MSQFRDNSWLANARSYGVLKSLRSSARYAKAKSKSAINLNAHLKKQQKLEEGHPEKKRQDKKILRQSVSEDQPIYANVDEVIPIHLEPETGTEVDALMGNAQPSKMNHLRVHKFKLGGKDNAAMADLPQSENTTNNNNNIGSNNNQKGGAKGFLGRIKRYSVLGNKLGRRNLGSMNLNPPNNVVDNSVSPTKLHTGSYNMTGSHSDDHRLEIGAPILISTTTLDTDRFDVTEARLKQIGGGIAQTSSIVRTLTPRSSDEEEFVDARSSPQQMERDEDLQIADDQVEKNDRDQYGHQFQLPKKQHREEEMGDLKYLDDLEEPEQFETPKHEVEEKLLTANQDVKRPITPITIAIDPPIRRPRIARQQRQSQSVQNLHRSELKVYLHKSNSVALDMNVTAPAKLGLDLNLPELPELYGASELSLAASDNKENLPAVKPSAERSPIPNGGFMAQQPHFKSLDSFHLNTRSHSNQSSQQSSRQSLACSSSNGEYDFDLKSVSYQSLNAQNLFVSIDELQELTRQINETEDFGKEIDLEYCAHRDQLRPSERRITLLKNKNQTLINFNHNKEKLRKGWHGMKHWLGEEGSKIKEAVRQQTPLKRLAQSRSNLNQSTADASRQSMSPERTQRDVTESCEDVTERTEMESSMSHRNSEEDLSPHAKRFKDEGQNGFEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPGSVADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARVLGEWRASEAKAKKASHTAARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRADVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMNPILGGLSTRLQPQLDACNVAKDMQVVRHIRRNSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLERERRSRDGLRGLSQSLNHQEHQNITDKLYHIRSMLTYLEGARLKLHSALLELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPDENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQNPTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGWWLGALRNHIGIFPATYVEECA
Protein: TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase (EC 2.4.1.325) (4-alpha-L-fucosyltransferase) (TDP-Fuc4NAc:lipid II Fuc4NAc transferase) (Fuc4NAc transferase) (P56258)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Lipid III flippase
- UDP-N-acetyl-D-mannosaminuronic acid transferase
- dTDP-fucosamine acetyltransferase
- dTDP-4-amino-4,6-dideoxygalactose transaminase
- Probable ECA polymerase
- Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- UDP-N-acetylglucosamine 2-epimerase
- UDP-N-acetyl-D-mannosamine dehydrogenase
- Glucose-1-phosphate thymidylyltransferase 2
- ECA polysaccharide chain length modulation protein
Sequence:
MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVVGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPTLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLFFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNEHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQILSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIAAREVA
Protein: Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) (Q6ZQ11)
Organism: Mus musculus (Mouse)
Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q86X52}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q86X52}. Secreted {ECO:0000250|UniProtKB:Q86X52}.
Interaction partners:
- Chondroitin sulfate synthase 2
- Chondroitin sulfate synthase 3
- Chondroitin sulfate N-acetylgalactosaminyltransferase 2
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Hexosyltransferase
Sequence:
MAARGRRAWLSMLLGLVLGFVLASRLVLPRASELKRVGPRRRPSPEGCRPGQEASQPGGARGDARGAQLWPQGSAAEGVPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVEFFSSEGSDTSIPIPVVPLRGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLESFLRSLNSSEPLFLGQTGLGTTEEMGKLALEPGENFCMGGPGVILSREVLRRMAPHIGKCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQLFYENYEQNKKGYIRDLHSSKIHRAITLHPNKNPPYQYRLHSYMLSRKIAELRHRTIQLHREIVLMSKYSSTEIQKEDLQLGIPPSFMRFQARQREEILEWEFLTGKYLYSATDGQPPRRGMDSAQREALDDIVMQVMEMINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKMQFVEHEELDAQELADRINQDSGSLSFLSNSLKKLVAFQLPGSKTEHKEPKEKKINILIPLSGRFDMFVRFMGNFEKTCLIPNLNVKLVILLFNSDSNPDKAKQVELMRDYRVKYPKADMQVLPVSGGFSRALALEVGSSQFNNESLLFFCDVDLVFTAEFLQRCRANTVLGQQIYFPIIFSQYDPKIVYSGKVPSDNHFAFTQKTGFWRNYGFGITCIYKGDLVRVGGFDVSIQGWGLEDVDLFNKVVQAGLKTFRSQEVGVVHIHHPVVCDPNLDPKQYKMCLGSKASTFGSTQQLAEMWLEKNDPSYSKGGSHGSARTA
Protein: Transcription factor 20 (W5ZR30)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMASETSGHQGYQGFRKEAGDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQPMQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNVNAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVRSPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKGGASEKAGSSPAQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKGSQEDDPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSKSPGSLRYSYKDSFGSAVPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNKSIGSLLENPHWGPWERKSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGRNDRLNPTLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGPQDSRPTPMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHTPFSPNSETLASAYHANTRAHAYGDPNAGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCWDLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRRVRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPAVTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAVQDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEEWRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQEGFPPKGYFPSGKKKGRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESKALPASSFMLQGPVVTESSVMGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCSHCQEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTEQSERG
Protein: Pre-rRNA-processing protein ESF1 (18S rRNA factor 1) (Q06344)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14690591}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 22
- Something about silencing protein 10
- Pre-rRNA-processing protein ESF2
- ATP-dependent RNA helicase HCA4
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 6
- Probable ATP-dependent RNA helicase DHR2
- RNA cytidine acetyltransferase
- ATP-dependent rRNA helicase RRP3
- ATP-dependent RNA helicase HAS1
Sequence:
MAGENPKKEGVDARFAGIYSDPKFKNTKTKDHKIKLDSRFSKKDLEVQHKSKVDKYGRKIKNAQNNRELEDFDKYFEKEAENDEDSEVNAKTVVDRARGEVPDDYVSSSDEFTSSDSESSGESEVESEEENEVEIENAKPESGDISKNLAVVNLDWDHVKSEDLMITFSSFVPKGGKIERVAIYPSEFGKERMQREEVEGPPKELFQKKNKNKTSKKKKTDDSDSDMDIGIKDLYEEGDADKDVDSRALRQYQLDRLRYYYAIVYCSDTTTSKAIYDNCDGTEYESTANMFDLRYVPDGMTFDDDVRDECSILPKNYRPHQFSTDALQHSSVKLTWDETPADRVEVAKRAFTQKEIDDMDFKAYLASDSDESDGQVDEEAKNKLKSLVGDFGFNSKKETPNDEDEEVDMEITFTPALEGGNEKSSEDKEETTIEKIRRKEKERRKARKQKVKELKQQSEKDKKSKLKSVNKKHTNDEEEIEKNAKSKAELELLMDDDDDTETQGTINNKAHFNMNEILRSEKEKHKKGRYQKKERIVEDTFTPDLEDPRFKEVFEDHDFAIDPTQPEFKGTQAMSKILKERSKRVKNKKRKLGGSENNMTNNADDNEDIGNLVNKLKKKSKSSKKVKV
Protein: Alcohol O-acetyltransferase (A0A1D8PJI2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MLIQPNHRRKPEFNERYYICRTIENYSTNFSIIVQYNRQISHNLLSNALYSLIKKNSWFVQNFFQIDQRNPATANGHNFEVRILEHVKFNDVVKFHQIDKFDEIIMESLNDHIFSMNNATLPLWKINVFEEMRPNGNQFISVSFDHSNYDGLSGVQFQKDLAKELLTAKDDLFYDVLFDYQRDFGNLPAKILPAVDNLTDLFDLGVLSSSSSILKKWVPFYDTICGFIWPSDPPIFDTDTPVTKNLQTKYKFLKLTSNQIGQISKYCRSHGITLTTYFDIICICALQETVFSVVKSSATHTSSLVAINGRRYYSDEIKNFLYGTLVCGAPIILPTIENKLEAMQIFHQEMTNDINTKKSFQSTGNLLKHANVWEYFQNKINKIGGRFTLTISNLGKISNSNDIFKFEQMYFVSNTGVVYNFVLNITTLPNGELTAVVGYIPEFEKYELNNKPIMNTFMEKFYDLLILTSS
Protein: UPF0053 inner membrane protein YfjD (P37908)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane protein YpjD
Sequence:
MEHISTTTLIIILIIMVVISAYFSGSETGMMTLNRYRLRHMAKQGNRSAKRVEKLLRKPDRLISLVLIGNNLVNILASALGTIVGMRLYGDAGVAIATGVLTFVVLVFAEVLPKTIAALYPEKVAYPSSFLLAPLQILMMPLVWLLNAITRMLMRMMGIKTDIVVSGSLSKEELRTIVHESRSQISRRNQDMLLSVLDLEKMTVDDIMVPRSEIIGIDINDDWKSILRQLSHSPHGRIVLYRDSLDDAISMLRVREAWRLMSEKKEFTKETMLRAADEIYFVPEGTPLSTQLVKFQRNKKKVGLVVNEYGDIQGLVTVEDILEEIVGDFTTSMSPTLAEEVTPQNDGSVIIDGTANVREINKAFNWHLPEDDARTVNGVILEALEEIPVAGTRVRIGEYDIDILDVQDNMIKQVKVFPVKPLRESVAE
Protein: Epidermal growth factor receptor pathway substrate 8 splice variant B (SH3 domain-containing protein) (G5EFE0)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MRRGGSMGPPSGDPYQSRPSPGGYYYNRSTPGGQPAPSPSHSQQSASSHHPRGVPMSQPIARRSDYRTGSEQMTPRSDHRGPSMGYGNGGSVDQRVDDVTPSYYVEHLATFAVGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDDNGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRVRNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPTVASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGFAPYGVADRAMATPNQIHRGHSAPPEHFRQPPPRERNMVDTAPNTPQSMQRTPKSRPPHRNMSVDNLEFDRLTLERERLEFEKAKIMERESRLRHEEKQIEDEKRRMHAEKDLITKETTQPVPPPAAVVTHQPITKRYDPPISISPPPQRNNYSHVKVTVDSDTSPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKNMHQRVGYVPHTILSMVPFEQQQYASPNHHNNSSSTGGYNNGHHQGPGMLPEDAPSYVKERQGKRGEFRYF