wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-dependent Clp protease proteolytic subunit 2, mitochondrial (EC 3.4.21.92) (ATP-dependent Clp protease proteolytic subunit 1, mitochondrial) (Endopeptidase ClpP2) (nClpP7) (Q9FN42)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the mitochondrial ATP-dependent Clp protease. Cleaves peptides in various proteins in a process that requires ATP hydrolysis (By similarity). Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11352464, ECO:0000269|PubMed:14593120, ECO:0000305|PubMed:25732537}.
Interaction partners:
- CLP protease regulatory subunit CLPX1
- ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic
- CLP protease regulatory subunit CLPX3
- ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
- ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 5, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- CLP protease regulatory subunit CLPX2
- Clp protease adapter protein ClpF
Sequence:
MMRGLVSGAKMLSSTPSSMATSIATGRRSYSLIPMVIEHSSRGERAYDIFSRLLKERIICINGPINDDTSHVVVAQLLYLESENPSKPIHMYLNSPGGHVTAGLAIYDTMQYIRSPISTICLGQAASMASLLLAAGAKGQRRSLPNATVMIHQPSGGYSGQAKDITIHTKQIVRVWDALNELYVKHTGQPLDVVANNMDRDHFMTPEEAKAFGIIDEVIDERPLELVKDAVGNESKDKSSS
Protein: Leucine-rich repeat LGI family member 4 (LGI1-like protein 3) (Leucine-rich glioma-inactivated protein 4) (Q8K1S1)
Organism: Mus musculus (Mouse)
Function: Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 22
- Disintegrin and metalloproteinase domain-containing protein 23
- Disintegrin and metalloproteinase domain-containing protein 11
Sequence:
MGGAGILLFLLAWAGAGVAWSPPKGKCPPHCSCSKENTLCEGSPELPESFSTTLLSLSLVRMGVSRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPPAVAQIQLNHLDPKKFKCRATELSWLQTVGESALSVESFSYQGEPHMVLAQPFAGRCLILVWDYSLQRFRPEEELSAPSVVSCKPLVLGPRLFILAARLWGGSQLWSRSSPDLRLTPVQVLAPQRLLRPNDAELLWLDGQPCFVVADASKAGSTTLLCRDGPGFYPRQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWVGGRFERRTDIPEAEDVYATKHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGSHVFQPLLIARDQLAILGSDFAFSQVFRFESDKGILEPLQELGPPALVAPRAFAQVTVAGRRFLFAACFKGPTQIYQHHELDLSA
Protein: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) (O94331)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Interaction partners:
- Dihydroorotate dehydrogenase
- Orotidine 5'-phosphate decarboxylase
- Protein transport protein got1
- Probable dihydroorotase
- Ribose-phosphate pyrophosphokinase 2
- Ribose-phosphate pyrophosphokinase 5
- Ribose-phosphate pyrophosphokinase 1
- Uridylate kinase
- Putative purine permease C1399.01c
- NADH-cytochrome b5 reductase 1
Sequence:
MSYKLELLRRALEHNVLKFGTFTLKSGRKSPYFFNSGNFTHGADLCALAEAYAETIIAMNVDFDVIFGPAYKGISLAAITAVKLYEKTGKSYGFAYNRKEAKSHGEGGNLVGAEMEGKKVLLLDDVITAGTAIREAISFLEPKHVKLAGIVLLLDRQERLDPEVNESTIGRLKKELNLPVSSILTLDDIVDFTKSDLTAAESKAMDAYRQQYQAK
Protein: Cadherin domain-containing protein (Q3UTK9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
DPDLGPSGNVTFSFSGHTPDRVRNLFSLHPTTGKLTLQGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPHITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSPVTAGPLDREARSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGSPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLVTKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAACGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSEDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Q4KWZ7)
Organism: Gallus gallus (Chicken)
Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD2B
- REV3 like, DNA directed polymerase zeta catalytic subunit.
- DNA polymerase kappa
- Proliferating cell nuclear antigen
- DNA polymerase eta
- DNA polymerase delta subunit 3
- Uncharacterized protein.
- DNA repair protein RAD51 homolog 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MRRGGWRKRAGEGDGWGGWGGYMSAKVKKLEDQFRSDSAIQHQRDGNSSSIFSGVAIYVNGFTDPSADELRRLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVVRPEWIVESIKAGRLLSHIPYQLYTKQSSVQKGLSFNSICKPEDAMPGPSNIAKDLNRVNHIKQCEMESEITPNGISSWNEEEEEDSDGLGFTKLDQILPERKQNGIQSHKDSTAIFNGHTHNTCISALKTQDCLVPSSNSVASRFSPGPVQEEGKPEKGIVDFRDCTMQQLQQSNKNTDFSWNPHRTMSNSSSSSSLHSNTKINGAHHSTVQGPSSTKSTSVPTPSKAASLSVSKPSDCSFISDFYSRSRLHHISTWKCELTEFVNSLQRKNSGVFPGREKLKKWKAGRSALKTDTGNVSVASSAKPQSCIMHVDMDCFFVSVAIRNRPDLKGKPVAVTSNRGAGKAPLRPGANPQLEWQYYQNKLLNGKAEIRIPDKLDSLVWEHSDSAHMNGVDCDLTVLSMAEIASCSYEARQAGIKNGMFFGQAKKLCPNLQAVSYDFNAYKEVAQTVYEILASYTHNIEAVSCDEALVDITEILTETRLTPDELANAIRDEIKAQTKCTASVGMGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGRSMESKLASLGIRTCGDLQCASMSKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEAAGMKGKRLTLKIMVRKAGAPVEPAKYGGHGICDNIARTVTLDHATDSAKVIGKETLNMFHTMKLNISDMRGVGIQVQQLVPISKTTSAQSAVQSGRLPGGSHSVIDLLHVQKAKKCSEEEHKEVFVAAMDLEISSDSRTCTVLPSRGTHLTAGLNSNVSKTDSAVKLNGLHSPISVKSRLNLSIEVPSASQLDKSVLEALPPDLREQVEQIYTIQQGETYGDSKREPINGCNTALLSQPVGTVLLQVPELQEPNANMGINVIALPAFSQVDPEVFAALPAELQAELKDAYDQRQKQPEQQPANAFVSKNPCLQLKHATTKNKKKIRKKNPVSPVKKIQSPLKNKLLGSPAKNMPAASGSPQKLIDGFLKQEGAAAQLEAVPSTSDASDPSALQTEQCGSFRPQAPNLAGAVEFNDVKTLLKEWITTISDPMEEDILQVVKYCTDLIEEKDLEKLDLVVKYMKRLMQSSVESVWNMAFDFILDNVQVVLQQTYGSTLKVI
Protein: Short transient receptor potential channel 4b (Transient receptor potential cation channel subfamily c member 4a) (U3N7D8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKSTRANKSDTSASDVSHPEGSLQYSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSAVVLTEPILKDKARSDFPKDFTDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLAGKVEQDVNESKCLMEEDERVLEEQEMEHIASSHEH
Protein: Cytochrome P450 2J5 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ5) (O54749)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 2U1
- Cytochrome P450 1A2
- Cytochrome P450 2E1
- Polyunsaturated fatty acid lipoxygenase ALOX12
- Polyunsaturated fatty acid 5-lipoxygenase
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Prostaglandin G/H synthase 2
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Polyunsaturated fatty acid
- Prostaglandin G/H synthase 1
Sequence:
MIMFLSSLVTTFWEALHLKTLVLAVVTFLFLINILRSRHPKNYPPGPWRLPFVGNFFQIDTKQTHLVLQQFVKKYGNVFSLELGQSPVVVVSGLPLIKEMFTHLDQNFVNRFMTPVRERITGKNGLVVSNGQTWKEQRRLALMALRNFGLGKKSLEERIQEETHHLVEAIREEGGQPFNPHLKLINAVSNIICSVTFGERFDYEDCQFQELLQLLDETMHLMGSSAGQLYNGFPCIMKYLPGPHQKIFRNWGKLKLFVSHIVKKHEKDWNPDEPRDFIDAFLIEMQKDPDRTTSFNEENLISTTLDLFLGGTETTSSTLRWALLYMSSYPEIQENVQAEIDRVIGHKRQVSLSDRESMPYTNAVIHEVQRMGNIVPLNSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLAKSELFIFFSALMQKFTFKPPINEKLSLKFRMGLILSPASYRICAIPRV
Protein: RE26062p (Q8SYZ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAELLFPQLERPLPSLPSLHYTLFAYREELRRRDAPFMKMSTIKLHLTDNLILQTIKNIRQYDTIEIMNLNQEIKLQAAADQTNEEGAQTGEARLAHRSPETQRGRQMALKSD
Protein: C-X-C motif chemokine 11-6 (B0R191)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for cxcr3.2. Chemotactic for macrophages.
Subcellular location: Secreted {ECO:0000305|PubMed:25573892}.
Interaction partners:
- Chemokine
- Chemokine
- C-C motif chemokine
- C-C motif chemokine 21
- Atypical chemokine receptor 3a
- Stromal cell-derived factor 1
- Chemokine
- C-C motif chemokine
- Chemokine
Sequence:
MKTLAAFLLLSCLIAGEVNGQDRSSRARCFCVDKGLNMVLLKNLDKVEIFPPSPSCNKHEIVVTLKNGAGQKCLNPDSKFTKNVVLKAIGKRMQQSVPHSTTTGTVKSSMTSSTSAPTAFK
Protein: Guanine nucleotide exchange factor VAV3 (VAV-3) (Q9R0C8)
Organism: Mus musculus (Mouse)
Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
Interaction partners:
- Lymphocyte cytosolic protein 2
- Tyrosine-protein kinase SYK
- Cell division control protein 42 homolog
- B-cell linker protein
- Ras-related C3 botulinum toxin substrate 2
- Tyrosine-protein kinase ZAP-70
- Transforming protein RhoA
- Tyrosine-protein phosphatase non-receptor type 11
- Tyrosine-protein kinase TXK
- SH3 domain-binding protein 2
Sequence:
MEPWKQCAQWLIHSKVLPPNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETRVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDQNLYQVFINYKERLVIYGQYCSGVESAISNLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTGTPAPGLHEGPPLHIQAGDTVELLRGDAHSVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEQPAGQRGNRTGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
Protein: Crt homolog 1 (Chloroquine resistance transporter paralog 1) (DdCRTp1) (Q9GSB0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May regulate endogenous transporter.
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:Q9N623}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTNNDKEKQPLLSSINNEDDNGATINIVEPVPWYSNIPQKIKNSMSKETITILIYVVLYVTSGVINSVLLKKVMNKFTNYAFFLSQLTNFGYVPIFGAVTAYKIFFTKDIPQETRDFPTRKFAIMGALDAITGFFVVIGGVSTSGPLQQLLNQAIIPFTMIASFIFLKERYSLIQLGGALVIIGGVVTSLIPSLLGGSSGGNKPFWNFFYLLSVIPGALSNVYKDIGFQAVADMDVWYLQYWDSLYQSIFGLFLFPVNNWLPPPATVKFEQILPFMKEGAECLAGINSIIPSYINGTSSFTATSCTYAPDATITCDDCHNAWIVIILYMTINIIYNIFILLVLKHAGATVYSIANTLRLPLTNIVFSIHFIMGSAVSPFSGLSVAGLVIILVGLGGYRVGSMIKQKKAAAAGGAIKVIPSYGPAGMDNIIPVQKEYIEPKSQAHLRNQFFGKLGINVPEARYRAANNNNYGDA
Protein: 6,7-dimethyl-8-ribityllumazine synthase (Q9LHC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Rhodanese-like domain-containing protein 11, chloroplastic
- Zinc finger/BTB domain protein
- Outer envelope pore protein 21B, chloroplastic
- Myb/SANT-like DNA-binding domain protein
- YlmG homolog protein 2, chloroplastic
- Inner membrane localized protein
- Alpha/beta-Hydrolases superfamily protein
- Uncharacterized protein At5g03900
- Low-density receptor-like protein
- Mitochondrial substrate carrier family protein
Sequence:
MQLSLVQVSSVSNFRSQSTIPTLSNSNPSCLLLQKSIFPGSKLTLHRIFRYPKKISNGSTRASLLETPILWAGRICVFYALVKAGFAGSKSNPIVSGLDTGGVDVEYDDGADLGFSKWLQNIKGNKPDKDAADKRKLVSKWHPTTKGTLRRNYRIPSKAEGNRLLKAIASLLSDDDHFRDATSHKGCQIRRESAHGQSVCCNNVRALFDELPTPHLVVEITPFPAGPLTENDYLKAEKLERILRSGANI
Protein: Histidinol dehydrogenase (HDH) (EC 1.1.1.23) (P06988)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Interaction partners:
- Imidazole glycerol phosphate synthase subunit HisF
- Histidine biosynthesis bifunctional protein HisB
- Histidine biosynthesis bifunctional protein HisIE
- ATP phosphoribosyltransferase
- Imidazole glycerol phosphate synthase subunit HisH
- 1-
- Histidinol-phosphate aminotransferase
- Bifunctional aspartokinase/homoserine dehydrogenase 1
- Chorismate synthase
- Uroporphyrinogen-III synthase
Sequence:
MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
Protein: N(6)-adenosine-methyltransferase IME4 (EC 2.1.1.348) (P41833)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation. M6A, which takes place on the adenosine of 5'-[AG]GAC-3' consensus sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24269006}. Nucleus, nucleolus {ECO:0000269|PubMed:24269006}. Note=Localizes in the nucleolus during the period of m6A mRNA accumulation.
Interaction partners:
- Karyogamy protein KAR4
- Sporulation-specific with a leucine zipper motif protein 1
- Protein MUM2
- Meiosis-inducing protein 1
- Meiosis induction protein kinase IME2/SME1
- Meiosis-specific transcription factor NDT80
- D-3-phosphoglycerate dehydrogenase 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- Zinc finger protein RME1
- Methylated RNA-binding protein 1
Sequence:
MINDKLVHFLIQNYDDILRAPLSGQLKDVYSLYISGGYDDEMQKLRNDKDEVLQFEQFWNDLQDIIFATPQSIQFDQNLLVADRPEKIVYLDVFSLKILYNKFHAFYYTLKSSSSSCEEKVSSLTTKPEADSEKDQLLGRLLGVLNWDVNVSNQGLPREQLSNRLQNLLREKPSSFQLAKERAKYTTEVIEYIPICSDYSHASLLSTSVYIVNNKIVSLQWSKISACQENHPGLIECIQSKIHFIPNIKPQTDISLGDCSYLDTCHKLNTCRYIHYLQYIPSCLQERADRETASENKRIRSNVSIPFYTLGNCSAHCIKKALPAQWIRCDVRKFDFRVLGKFSVVIADPAWNIHMNLPYGTCNDIELLGLPLHELQDEGIIFLWVTGRAIELGKESLNNWGYNVINEVSWIKTNQLGRTIVTGRTGHWLNHSKEHLLVGLKGNPKWINKHIDVDLIVSMTRETSRKPDELYGIAERLAGTHARKLEIFGRDHNTRPGWFTIGNQLTGNCIYEMDVERKYQEFMKSKTGTSHTGTKKIDKKQPSKLQQQHQQQYWNNMDMGSGKYYAEAKQNPMNQKHTPFESKQQQKQQFQTLNNLYFAQ
Protein: RAN binding protein 3 (K7EIJ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSDDDDVLAPSGATAAGAGDE
Protein: CDPK-related kinase 1 (AtCRK1) (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase 3) (Calmodulin-binding protein kinase 3) (AtCBK3) (CaM-binding protein kinase 3) (O80673)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Serine/threonine kinase that phosphorylates histone H3. Confers thermotolerance; involved in the heat-shock-mediated calmodulin-dependent signal transduction leading to the activation of heat-shock transcription factors (HSFs); phosphorylates HSFA1A.
Subcellular location: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Calmodulin-7
- Heat stress transcription factor A-1a
- Calmodulin-1
- Calmodulin-6
- Calmodulin-like protein 10
- Calcium-binding protein CP1
- Calmodulin-2
- Calmodulin-3
- Serine/threonine-protein phosphatase 7
- Probable cyclic nucleotide-gated ion channel 6
Sequence:
MGICHGKPVEQQSKSLPVSGETNEAPTNSQPPAKSSGFPFYSPSPVPSLFKSSPSVSSSVSSTPLRIFKRPFPPPSPAKHIRAFLARRYGSVKPNEVSIPEGKECEIGLDKSFGFSKQFASHYEIDGEVGRGHFGYTCSAKGKKGSLKGQEVAVKVIPKSKMTTAIAIEDVSREVKMLRALTGHKNLVQFYDAFEDDENVYIVMELCKGGELLDKILQRGGKYSEDDAKKVMVQILSVVAYCHLQGVVHRDLKPENFLFSTKDETSPLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRTYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVLKAEPNFEEAPWPSLSPEAVDFVKRLLNKDYRKRLTAAQALCHPWLVGSHELKIPSDMIIYKLVKVYIMSTSLRKSALAALAKTLTVPQLAYLREQFTLLGPSKNGYISMQNYKTAILKSSTDAMKDSRVFDFVHMISCLQYKKLDFEEFCASALSVYQLEAMETWEQHARRAYELFEKDGNRPIMIEELASELGLGPSVPVHVVLQDWIRHSDGKLSFLGFVRLLHGVSSRTLQKA
Protein: (+)-alpha pinene synthase 1, chloroplastic (EC 4.2.3.121) (Terpene synthase (+)alphapin1) (PbTPS-(+)alphapin1) (R9QMR1)
Organism: Pinus banksiana (Jack pine) (Pinus divaricata)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (+)-alpha-pinene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALVSAVPLNSKLCLCRTLFGFSHELKAIHSTVPNLGMCRGGKSIAPSMSMSSTTSVSNEDEAPRRIAGHHSNLWDDDSIASLSTSYEAPSYREGADRLIGEVKNIFDLMSVEDGVFTSPLSDLHHRLWMVDSVERLGIDRHFKDEINSALDHVYSYWTEKGIGRGREGGVTDLNSTALGLRTLRLHGYTVSSHVLDHLKNEKGQFTCSAIQTEGEIRDVLNLFRASLIAFPGEKIMEAAEIFSTMYLKDALQKIPPSGLSQEIEYLLEFGWHTNLPRMETRMYIDVFGEDTTFETPYLIREKLLELAKLEFNIFHSLVKRELQSLSRWWKDYGFPEITFSRHRHVEYYTLAACIANDPKHSAFRLGFGKISHMITILDDIYDTFGTMEELELLTAAFKRWDPSSIECLPDYMKGVYMAVYDNINEMAREAQKIQGWDTVSYARKSWEAFIGAYIQEAKWISSGYLPTFDEYLENGKVSFGSRITTLEPMLTLGFPLPPRILQEIDFPSKFNDLTCAILRLKGDTQCYKADRARGEEASAVSCYMKDHPGITEEDAVNQVNAMVDNLTKELNWELLRPDSGVPISYKKVAFDICRVFHYGYKYRDGFSVASVEIKNLVTRTVVETVPL
Protein: Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase) (Q14642)
Organism: Homo sapiens (Human)
Function: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:8626616, ECO:0000305|PubMed:8006039}; Lipid-anchor {ECO:0000269|PubMed:8626616, ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TNC9}.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- Inositol polyphosphate 5-phosphatase K
- Inositol-trisphosphate 3-kinase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
- Inositol-trisphosphate 3-kinase B
- Inositol-trisphosphate 3-kinase C
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Multiple inositol polyphosphate phosphatase 1
- Inositol polyphosphate-4-phosphatase type I A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Sequence:
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
Protein: G-protein coupled receptor 81 (Hydroxycarboxylic acid receptor 1-2) (C6EVZ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNNSSLCCTYETPLLDAYLPPVLFSEFVLGLMGNGLALCMFFFHRDSWKPNSIYLAHLALADSLVLFCLPFRADYYRRGKHWVYGDAFCRVLLFLLAANRAAGIFFLTAVAVDRYLKIVHPLNRINQMGLRYALWVSVGLWALIIAMTVYLLADKHFYYLNNHTQCESFNICFGSNSRFTWHNVFYVIQFFVPTFIVIYCSTCITWQLKGKTIDKHGKIRRAVRFVLAVALVFIICFFPSNISRISMYVLKLWYNECQYFSDANDAFKTTVCFTYFNSVLNPVVYYFSSPAVSGSLRKIYMRMLGQKIEE
Protein: Forkhead box protein C2-A (FoxC2-A) (FoxC2a) (Fork head domain-related protein 4) (FD-4) (xFD-4) (xFD4 A) (Forkhead protein 7) (FKH-7) (xFKH7) (Q9PVY9)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional activator (By similarity). May be involved in the dorso-ventral patterning of the mesoderm.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q99958}.
Interaction partners:
Sequence:
MMQARYSVADPNALGVVPYLSEQNYYRAAGTYGSMATPMSVYPTHEQYTQGMGRSYGPYHHHQPTAPKDLVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWSLDPDSYNMFENGSFLRRRRRFKRKDVCREKEDRLLKDQGKAQGPISSLELPKHEKKIVIKSESPELPVITKVENLSPDGGSAMQDSPRSVASTPSVSTDNSIPDQHPASNGFSVENIMTLRTSPHGDLSPVPQVPCRTGMVPSLPINYTAQTQSSVYSQACTQSMDTSGSYQCTMRAMSLYAGDRPSHMCAPSSLEEATSEHHNGTSSPLTSMSLGSGQESVLTSSHHQQTATGGQTAAPWYLNPGADIGHLSGHNFGSQQQTFPNVREMFNSHRLGIESSALSEHQVSGNTNCQIPYRSAPSIYRHSSPYAYDCTKY
Protein: Forkhead box N2 (E9PYQ6)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MGPVIGMTPDKRAETPGAEKVAGLSQIYKMGSLPEAGDAARPKATLVGSESADDELTNLNWLHESSNLLTNLRLGSEGLPMVSPLYDIEGDEMPSFGPSCYQNPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDRFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKPFLQNLRSHSQSFIVHDSEEENAYFLFSS
Protein: p-benzoquinone reductase (EC 1.6.5.6) (NAD(P)H dehydrogenase (quinone)) (C1I202)
Organism: Pseudomonas sp. (strain WBC-3)
Function: Involved in the degradation of para-nitrophenol (PNP). Catalyzes the reduction of p-benzoquinone to hydroquinone.
Interaction partners:
Sequence:
MPTKIQIVFYSSYGHIYKMAEAIAAGAREVGDVEVTLLQVPELMPEEVQVKSGIKGYRAAFGSIPYATPEVLAEADAIIFGTPTRFGNMCSQMRNFLDQTGGLWMSGGLIGKVGSVFTSTASQHGGQETTITSFHTTLLHHGMVIVGVPYSEPGLTNMTEISGGTPYGASTLAGADGSRQPSENELQIARFQGKHVATIAKRLANNK