wanglab/gogpt-training-data huggingface dataset:
Protein: POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7) (P31360)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes.
Subcellular location: Nucleus.
Interaction partners:
- Myelin transcription factor 1-like protein
- Transcription factor SOX-2
- Achaete-scute homolog 1
- Sal-like protein 2
- T-box brain protein 1
- Neurogenin-2
- Neurogenic differentiation factor 1
- Paired box protein Pax-6
- Forkhead box protein J2
- Oligodendrocyte transcription factor 2
Sequence:
MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
Protein: Estradiol 17-beta-dehydrogenase (EC 1.1.1.62) (A0A0A0MQS7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR000095}.
Interaction partners:
Sequence:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
Protein: ATP13A2 protein (Q8N4D4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
RDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQKRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFKLLLLGLVTLNFVGAFMLESVLDQCLPACLRRLRPKRASKKRFKQLERELAEQPWPPLPAGPLR
Protein: Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (P90526)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL15
- Elongation factor Tu
- Large ribosomal subunit protein uL22
- Eukaryotic translation initiation factor 1A
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein eL38
- Small ribosomal subunit protein uS13
Sequence:
MNSSLQISKKRKFVADGVFHAELNELFTREFNKDEGYSGVELKTSPGLTEIIIRASKTQAVVGPNARRIQELCSLVQKRFNFKEGTVVLFAEKILNRGLCAVAQAESLKLKLLAGLPVRKACYAIVHQIMTRGAKGCEVIVSGKLRAQRAKSMKFRDGYMIKSGQPSKDFIDFACRHVLLRQGTLGVKVAIMLPYDETRKIHGACNIPQPDVVVIRDA
Protein: Cytospin-A (SPECC1-like protein) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (Q2KN93)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cell junction, gap junction {ECO:0000250}. Note=Colocalizes with beta-tubulin, acetylated alpha-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MKKAGRPVGNKAASGGGKGDSVTAGNCAGKNTVKSPTSAPLSKVKSNDDLLAAMAGSSAGTNNSVAKGKKSTSTHSTSCGTNTNNPDTKTKTTSGPSGKRTTSMTSKESNSSRERLRNSRNSSSKKQSSTGASDRAQPKHSRALAQTSDSESRMSKSKSDGQLSDKVALEAKVKNLLGLAKSKDVEILQLRGELRDMRVQLGLPEEDEEEERPPEREAAAVITAADVESTLLLLQEQNQAIRGELNLLKNENRMLKDRLNALGFSLEQRLDGADKTFGFPSTSPELSSGGAGAHGDCATVASSVEGSAPGSMEDLLTGGQRSGSTDNLDSESSEVYQAVTSSDDALDAPSGCGSSSSSESEGGPPACRSSSRKGSSGNTSEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNGENERLGEEKVLLMDSLCQQSDKLEHCGRQIEYFRSLLDEHGVAYSVDEDIKSGRYMELEQRYVELAENARFEREQLLGVQQHLSNTLKMAEQDNAEAQNVIAALKERNHHMERLLDVERQERASMAAVLEECKAAVNNDQAELSRCRVLLEQERQKVAELYSIHNAGDKSDIHQLLEGVRLDKEEAEAKASKLQDDLGHARSEVACLQDTLNKLDAEYRDFQSVVQKELAEQKRAIEKQREDLQEKETEIGDMKETIFELEDEVEQHRAVKLHDNLIISDLENSMKKLQDQKHDMEREIKILHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLRRRLQEAQEKNEKLGKEIEEVKNRKQDEERGRVYNYMNAVERDLAALRQGMGLSRRPSTSSEPSPTVKTLIKSFDSASQGPGANATAVAAAAAAAAAAAAVTVTSTTPTAPLPRTPLSPSPMKTPPAAAVSPIQRHSITGSMAAAKPLSSLADKRPSYTDISMPAEHLLRAANSRPASALQRVSNMDTSKTITVSRRSSEEPKRDISTPDGGPASSLISMSSAAALSSSSSPTASVNPTARSRLREERKDPLSALAREYGGSKRNALLRWCQKKTEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELNSQDKRRNFTLAFQAAESVGIKSTLDITDMVHTERPDWQSVMTYVTSIYKYFET
Protein: Prophage integrase IntF (Putative prophage CP4-6 integrase) (P71298)
Organism: Escherichia coli (strain K12)
Function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Interaction partners:
- Prophage integrase IntR
- Uncharacterized protein YagN
- Prophage integrase IntD
- Prophage integrase IntE
- Prophage integrase IntS
- Prophage integrase IntA
Sequence:
MFIPSIYLHQQLHYCKTAILNWSRKMALSRQKFTFERLRRFTLPEGKKQTFLWDADVTTLACRATSGAKAFVFQSVYAGKTLRMTIGNINDWKIDDARAEARRLQTLIDTGIDPRIAKAVKIAEAESLQAESRKTKVTFSVAWEDYLQELRTGISAKTKRPYSTRYIADHINLSSRGGESKKRGQGPTSAGPLASLLNLPLSELTPDYIAAWLSTERQNRPTVTAHAYRLLRAFIKWSNYQKKYQGIIPGDLAQDYNVRKMVPVSASKADDCLQKEQLKSWFSAVRSLNNPIASAYLQVLLLTGARREEIASLRWSDVDFKWSSMRIKDKIEGERIIPLTPYVSELLNVLAQSPNSDVNKEGWVFRSNSKSGKIIEPRSAHNRALVLAELPHISLHGLRRSFGTLAEWVEVPTGIVAQIMGHKPSALAEKHYRRRPLDLLRKWHEKIETWILNEAGITIKNNVDMR
Protein: Resistin (Q8K4J7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- 30 kDa adipocyte complement-related protein
- Toll-like receptor 4
- Leptin
- Adenylyl cyclase-associated protein 1
- Nicotinamide phosphoribosyltransferase
- Complement factor D
- Tumor necrosis factor
- Insulin-2
- Insulin-1
- Adiponectin receptor 1
Sequence:
MKNLSFLLLFLFFLVLGLLGPSMSLCPMDEAISKKINQDFSSLLPAAMKNTVLHCWSVSSRGRLASCPEGTTVTSCSCGSGCGSWDVREDTMCHCQCGSIDWTAARCCTLRVGS
Protein: Iron-dependent repressor IdeR (P9WMH1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators.
Subcellular location: Cytoplasm.
Interaction partners:
- RNA polymerase sigma factor SigB
- Zinc uptake regulation protein
- Bacterioferritin BfrA
- Bacterioferritin BfrB
- Serine protease PepD
- PspA protein
Sequence:
MNELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMERDGLLRVAGDRHLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLVKVLNNPTTSPFGNPIPGLVELGVGPEPGADDANLVRLTELPAGSPVAVVVRQLTEHVQGDIDLITRLKDAGVVPNARVTVETTPGGGVTIVIPGHENVTLPHEMAHAVKVEKV
Protein: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) (P50136)
Organism: Mus musculus (Mouse)
Function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P12694}.
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Branched-chain-amino-acid aminotransferase, cytosolic
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase protein X component, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- L-lactate dehydrogenase B chain
Sequence:
MSAAKIWRPSRGLRQAALLLLGRSGVRGLARSHPSRQQQQQFPSLDDKPQFPGASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVLKFYRSMTLLNTMDRILYESQREGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMSQCYGNVNDPGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRIVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIKSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDHFEK
Protein: Peptide chain release factor subunit 1 (Translation termination factor aRF1) (Q97W96)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- RNase L inhibitor
- Elongation factor 1-alpha
- Large ribosomal subunit protein eL15
- Translation initiation factor 2 subunit alpha
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS4
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS2
Sequence:
MSXDEYALNKQELKALIKELKKWKAPATVLLSLYIPPGRPIPDVVNLLRQEYSIAQNIKLKRTRDAVLSAIGAAIDRLNKIPKIDGNGLVLFCGENFDTEDFKCFMFSPPDKVPLFFYRTDKEFHLEFLEDMVEDTAVYGLIIVERDEATIGLLKGARIEILEEIEGFVPGKHMMGGQSQRRIDRIIDEMYHNFLKEVGEKVNAYFMPFVQNGKMKGVLLGGPGYAKEDFYKEDYVDYRIKNLILQPLIDVSDQGEVGLREMIMKAEDLLKNQQYIEVEKLLEELKYHLAKDDGLIIYGKEQIKKAMEIGAIEAIVIHEDSTDKELEKLAQDAENYGVKVFVVGDEVPEAEWVKKTFNGIVGKLRYRLY
Protein: Protein Ac75 (Q06669)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Plays a role in nuclear egress of nucleocapsids and intranuclear microvesicle formation.
Subcellular location: Virion {ECO:0000269|PubMed:28968422, ECO:0000269|PubMed:29212928}. Host cytoplasm {ECO:0000269|PubMed:28968422, ECO:0000269|PubMed:29212928}. Host nucleus {ECO:0000269|PubMed:28968422, ECO:0000269|PubMed:29212928}. Note=Localizes predominantly in the host intranuclear rim, site of several morphogenetic processes associated with occlusion-derived virions (ODV). {ECO:0000269|PubMed:29212928}.
Interaction partners:
Sequence:
MSNLMKNFFTELVKSTTFTTKVSVVKTTLSNWLCEQVYPDKDFSLKLKRVVNMFLNNEIENNKIYKLVETVDSSNKLSRRQVDFLIHALLNNVSVTFTLHRFVDDNVLTQDELSFLANFLVTKMDEAYQLPAY
Protein: Beclin-2 (P0DM65)
Organism: Mus musculus (Mouse)
Function: Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphoinositide 3-kinase regulatory subunit 4
- Beclin 1-associated autophagy-related key regulator
- Apoptosis regulator Bcl-2
- Nuclear receptor-binding factor 2
- UV radiation resistance-associated protein
- Beclin-1
- Bcl-2-like protein 1
- RB1-inducible coiled-coil protein 1
- Serine/threonine-protein kinase ULK1
Sequence:
MSPALFLCQRCKEPLKLLQQQGGPLEVQHHANTPTEIPVSAESQVRTSGRPHSDGGRVSQGSALCTFTLLTSGGPDSEGGTTSQGNACCTFTLLGESASMRTMNTIQNTVLETFEILSDQKVVDHPLCVDCTDHLLMQLDDQLALLASDNQKYKSFQDRELLVSEEEREALHAELCAELSSLEQEEARLTQELEDLDGHHARVAAELRAAQAESKELYKQHEQHRVEYSVFKMEQLELMDQLSSVENQLTYALSQQYRLRQTNIFNATFTISDEGPLGVINNFRLGCLPGVRVGWTEISSAWGQTVLLLFSLSKIAGLQFQRYQLVPFGDHSYLKSLTGDGVLPLFSDGSHSVFLNNKFDCGMKAFLDCLQQFVEEIERDERCPCLPYRIHVKEGLMEDVWDSGECCSIRTHLNTEEEWSRALKFMLSDLKLILAWASLRFSRVQRP
Protein: Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) (Q15365)
Organism: Homo sapiens (Human)
Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:7607214}. Cytoplasm {ECO:0000269|PubMed:7607214}. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214). {ECO:0000269|PubMed:7607214}.
Interaction partners:
- Poly
- Pre-mRNA-processing-splicing factor 8
- Zinc finger protein 830
- Heterogeneous nuclear ribonucleoprotein K
- Polypyrimidine tract-binding protein 1
- Elongation factor 1-alpha 1
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein L
Sequence:
MDAGVTESGLNVTLTIRLLMHGKEVGSIIGKKGESVKRIREESGARINISEGNCPERIITLTGPTNAIFKAFAMIIDKLEEDINSSMTNSTAASRPPVTLRLVVPATQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGVPQSVTECVKQICLVMLETLSQSPQGRVMTIPYQPMPASSPVICAGGQDRCSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVARQQSHFAMMHGGTGFAGIDSSSPEVKGYWASLDASTQTTHELTIPNNLIGCIIGRQGANINEIRQMSGAQIKIANPVEGSSGRQVTITGSAASISLAQYLINARLSSEKGMGCS
Protein: Intraflagellar transport protein 52 homolog (Protein NGD5) (Q62559)
Organism: Mus musculus (Mouse)
Function: Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Required for the anterograde transport of IFT88 (By similarity).
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19253336, ECO:0000269|PubMed:31637240}.
Interaction partners:
- Intraflagellar transport protein 20 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 22 homolog
Sequence:
MEKELRSTILFNAYKKEVFTTNTGYKSLQKRLRSNWKIQSLKDEITSEKLIGVKLWITAGPREKFTAAEFEVLKKYLDSGGDILVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYYKYFHPKEALVSDGVLNREISRAAGKAVPGVIDEENSGNNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGFGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLNQIDAEDPEISDYTMVPDTATLSEQLRVCLQEGDENPRDFTTLFDLSIYQLDTTCLPKVIKAHEELNVKHEPLQLVQPQFEMPLPALQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTDEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHIFFQVVEFKKLNQEAH
Protein: Baseplate wedge protein gp10 (Gene product 10) (gp10) (P10928)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Peripheral baseplate protein that is part of the tail fiber network. Connects the short tail fibers to the baseplate. During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04106, ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:2403438, ECO:0000269|PubMed:27193680}. Note=Present in 18 copies in the baseplate. {ECO:0000303|PubMed:21129200}.
Interaction partners:
Sequence:
MKQNINIGNVVDDGTGDYLRKGGIKINENFDELYYELGDGDVPYSAGAWKTYNASSGQTLTAEWGKSYAINTSSGRVTINLPKGTVNDYNKVIRARDVFATWNVNPVTLVAASGDTIKGSAVPVEINVRFSDLELVYCAPGRWEYVKNKQIDKITSSDISNVARKEFLVEVQGQTDFLDVFRGTSYNVNNIRVKHRGNELYYGDVFSENSDFGSPGENEGELVPLDGFNIRLRQPCNIGDTVQIETFMDGVSQWRSSYTRRQIRLLDSKLTSKTSLEGSIYVTDLSTMKSIPFSAFGLIPGEPINPNSLEVRFNGILQELAGTVGMPLFHCVGADSDDEVECSVLGGTWEQSHTDYSVETDENGIPEILHFDSVFEHGDIINITWFNNDLGTLLTKDEIIDETDNLYVSQGPGVDISGDVNLTDFDKIGWPNVEAVQSYQRAFNAVSNIFDTIYPIGTIYENAVNPNNPVTYMGFGSWKLFGQGKVLVGWNEDISDPNFALNNNDLDSGGNPSHTAGGTGGSTSVTLENANLPATETDEEVLIVDENGSVIVGGCQYDPDESGPIYTKYREAKASTNSTHTPPTSITNIQPYITVYRWIRIA
Protein: Adhesion molecule with Ig like domain 2 (F1N348)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Factor XIIa inhibitor
- Hexosyltransferase
Sequence:
MSLRLHALPTLPGVVRPGCKQLLCLLVITMTVSRGASGVCPTACICATDIVSCTNKNLSRVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSLVKLNTLIIRHNNITSISTDSFSTTPNLKCLDLSSNKLKTVKSAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRISSLPMHHINLVPGKQLRGIFLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDTRHFHQVLLLQDSFLNCSDSIINSSFRALGFIHEAQVGERLMVHCDGKTGRANTDFMWVGPDNRVLEPDKEMENFHVFPNGSLVIESPRFEDAGVYSCVAMNRQRLLNETVDVTINVSNFTINKSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKHKRRKNMLNQSNVHASILTSGPDSDAPTDERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSETVIAEGILKSTRVKSDSDSVNSVFSDTPFVAST
Protein: Acanthoscurrin-2 (Q8I6R7)
Organism: Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)
Function: Antimicrobial protein. Strong activity against the Gram-negative bacterium E.coli SBS363 and yeast C.albicans. No detectable activity against the Gram-positive bacterium M.luteus.
Subcellular location: Secreted {ECO:0000269|PubMed:12818635}.
Interaction partners:
Sequence:
DVYKGGGGGRYGGGRYGGGGGYGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGRGGYGGGGYGGGYGGGYGGGKYKG
Protein: ATPase expression protein 1 (A0A1D8PPI1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLETRILRSLPQVRKYSVKRFRSPFSFLPNETKHIFDEEKLTPEENKAAIPLKPNYDNLEKIHHEVINPEEVSDLVVKLNSNDILVSILSKDGYLFGDKNYLLTGTNKPTRFKATSILNSWCRIFNNQIKDLKEISPMQFWDPVVSPQISKAIEEYGDNFEKLFQETRALKNSKLKKHGDIPPSELVDMITVDNLSLYVLNNLSSIESLAVFVGFMRNHIEYYTVEGLSEILAKLTDICYRLHGDIDYELYLSVKQKHPGVIQKLPSDTIDKLANLLASKNWELSKELIRVLIKRDVCPSETTMNEFLLNFVNSDPETKLKELSFLKSAIFSRGVNELSLQIVLTTIRNIHEFSKLIELIKTSNQCQLILSKYQHILFATLKRVTTNLPLQKAQFVRVLTENNVHVDNDLMRVLEN
Protein: Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (O60244)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 27
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 26
- Mediator of RNA polymerase II transcription subunit 29
Sequence:
MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Protein: Gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Q06145)
Organism: Rattus norvegicus (Rat)
Function: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Subcellular location: Secreted.
Interaction partners:
- Gastric inhibitory polypeptide receptor
- Glucagon-like peptide 1 receptor
- Dipeptidyl peptidase 4
- Glucose-dependent insulinotropic receptor
- Vasoactive intestinal polypeptide receptor 2
- Pro-glucagon
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- 5-hydroxytryptamine receptor 4
- Adrenocorticotropic hormone receptor
- Lutropin-choriogonadotropic hormone receptor
Sequence:
MVALKTCSLLLVLLFLAVGLGEKEEVEFRSHAKFAGPRPRGPRYAEGTFISDYSIAMDKIRQQDFVNWLLAQKGKKNDWKHNLTQREARALELAGQSQRNEEKEAQGSSLPKSLSDEDVLRDLLIQELLAWMADQAELCRLRSQ