wanglab/gogpt-training-data huggingface dataset:
Protein: Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) (Q9H3M0)
Organism: Homo sapiens (Human)
Function: Putative voltage-gated potassium channel.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14721}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ubiquitin-like protein FUBI
- V-type proton ATPase subunit C 2
- Voltage-gated potassium channel subunit beta-3
- Heterogeneous nuclear ribonucleoprotein K
- Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-1
- RNA-binding protein Nova-2
Sequence:
MDGSGERSLPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPAGKEAPSCSSRLKLSHSDTFIPLLTEEKHHRTRLQSCK
Protein: Thioredoxin reductase 1 (TR-Se) (TRR) (EC 1.8.1.9) (Q17745)
Organism: Caenorhabditis elegans
Function: Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Thioredoxin
- Thioredoxin domain-containing protein
- Probable selenide, water dikinase
- Kynurenine--oxoglutarate transaminase
- Kynurenine--oxoglutarate transaminase
- Putative cystathionine gamma-lyase 2
- cystathionine gamma-lyase
- Selenocysteine lyase
- Probable glutathione reductase 2
- Glutaredoxin domain-containing protein
Sequence:
MKSLTELFGCFKRQPRQQEASSPANPHVSDTLSMGVAASGMPPPKRPAPAESPTLPGETLVDAPGIPLKEALKEAANSKIVIFYNSSDEEKQLVEFETYLNSLKEPADAEKPLEIPEIKKLQVSRASQKVIQYLTLHTSWPLMYIKGNAVGGLKELKALKQDYLKEWLRDHTYDLIVIGGGSGGLAAAKEASRLGKKVACLDFVKPSPQGTSWGLGGTCVNVGCIPKKLMHQASLLGHSIHDAKKYGWKLPEGKVEHQWNHLRDSVQDHIASLNWGYRVQLREKTVTYINSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYPEIPGVKEYTITSDDLFQLPYSPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHMIAYGMKFEAGVPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTDDVGLTTIGVERAKSKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIFDGANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISERMDKDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAENFTTLTLEKKEGDEELQASGCUG
Protein: Rho guanine nucleotide exchange factor 8 (AtRopGEF8) (Rho of plants guanine nucleotide exchange factor 8) (Q9LV40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. Active as homodimer.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16415208, ECO:0000269|PubMed:22500990}. Note=Localizes to the apical region of the pollen tube plasma membrane.
Interaction partners:
- Rac-like GTP-binding protein ARAC5
- Rac-like GTP-binding protein ARAC2
- Pollen receptor-like kinase 6
- Pollen receptor-like kinase 5
- Kinesin-like protein
- Serine/threonine-protein kinase AGC1-7
- Serine/threonine-protein kinase AGC1-5
- Pollen receptor-like kinase 2
- Protein RALF-like 3
- Fimbrin-5
Sequence:
MVAALERGLSASKSFNFKRMFDSSSTKQQQSQTIVVENGDSHIVESNTPESQNSDSFVESPVESSLPMISPLTRPGKRSERQQADMEMMKDRFAKLLLGEDMSGGGKGVSSALALSNAITNLAASIFGEQTKLQPMPQDRQARWKKEIDWLLSVTDHIVEFVPSQQTSKDGVCTEIMVTRQRGDLLMNIPALRKLDAMLIDTLDNFRGHNEFWYVSRDSEEGQQARNDRTNDKWWLPPVKVPPGGLSEPSRRMLYFQKDSVTQVQKAAMAINAQVLSEMEIPESYIDSLPKNGRASLGDSIYKSITEEWFDPEQFLAMLDMSTEHKVLDLKNRIEASVVIWKRKLHTKDTKSSWGSAVSLEKRELFEERAETILVLLKQKFPGLPQSSLDISKIQFNKDVGQAVLESYSRILESLAYTVMSRIEDVLYTDTLALKQTLLAEETSDGGRTTETDSESAGSSNSGEEAEKHDPHSKTLLDFMGWNDNSSKGGDKPTKSPNLTPKKLSYLEKLENLNGFRSPKDRH
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q504C0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Ubiquitin-like protein NEDD8
- Ubiquitin-ribosomal protein eS31 fusion protein
- SUMO peptidase family member, NEDD8-specific
- NEDD8-activating enzyme E1 catalytic subunit
- Polyubiquitin-B
- Polyubiquitin-C
- Ubiquitin-specific peptidase 43a
- Proteasome subunit alpha type
- Si:ch211-202a12.4.
- Ubiquitin carboxyl-terminal hydrolase.
Sequence:
MEGQRWLPLEANPEVMNQFLRQLGLVPTWQFGDVYGLELEVLSLVPRPVCAVLLLFPITEKYETFRQEEEAKIKGQGQEVSSDVYFMKQTIGNACGTIGLIHAVANNQNHLEFELNSPLKTFLLQSAKMSPEEKAAFLEKDESIRVTHESSAQEGQTEAPGLDEKVDLHFIAFVNVDGHLYELDGRKPFPIVHGKTTEDTFLEDSAEVCKKFMARDPQELRFTVVALSKA
Protein: NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) (Q64669)
Organism: Mus musculus (Mouse)
Function: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05982}.
Interaction partners:
- Vitamin K-dependent gamma-carboxylase
- Vitamin K epoxide reductase complex subunit 1
- Ornithine decarboxylase
- Vitamin K epoxide reductase complex subunit 1-like protein 1
- Heme oxygenase 1
- Glutamate--cysteine ligase regulatory subunit
- Nuclear factor erythroid 2-related factor 2
- Glutamate--cysteine ligase catalytic subunit
- Kelch-like ECH-associated protein 1
- Quinone oxidoreductase
Sequence:
MAARRALIVLAHSEKTSFNYAMKEAAVEALKKRGWEVLESDLYAMNFNPIISRNDITGELKDSKNFQYPSESSLAYKEGRLSPDIVAEHKKLEAADLVIFQFPLQWFGVPAILKGWFERVLVAGFAYTYAAMYDNGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARMQILEGWKKRLETVWEETPLYFAPSSLFDLNFQAGFLMKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK
Protein: RAB30, member RAS oncogene family (E9PS06)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVSQQRAEE
Protein: Quinolinate synthase, chloroplastic (EC 2.5.1.72) (Protein ONSET OF LEAF DEATH 5) (Protein SULFUR E 3) (Q9FGS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. Can complement nadA-deficient E.coli mutant. Essential for the de novo synthesis of NAD. Participates also in cysteine desulfurization mediated by NFS2. Can activate the cysteine desulfurase activity of NFS2 in vitro.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16698895, ECO:0000269|PubMed:17452319}.
Interaction partners:
- Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic
- L-aspartate oxidase, chloroplastic
- Nicotinate phosphoribosyltransferase 2
- Nicotinate phosphoribosyltransferase 1
- Cysteine desulfurase 1, chloroplastic
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Nicotinamidase 1
- NifU-like protein 5, mitochondrial
- Monothiol glutaredoxin-S14, chloroplastic
- NifU-like protein 4, mitochondrial
Sequence:
MALALSVAPTSSSLSSLLSRTPNPSPNFRTTHLNFGSQRRIYTINPLLRSFKCLQSSSRDVNASPFSISAIASSSSSSQTTELVPYKLQRLVKEFKSLTEPIDRLKWVLHYASLLPQMPESSKTESNRVMGCTARVWLDAELGQDGKMRFCADSDSDVSKGMCSCLIQVLDEASPVEVMELKTEDLAELNVGLLGGERSRVNTWYNVLVSMQKKTRRLVAEREGKVPSFEPFPSLVLTAHGIEAKGSFAQAQAKYLFPEESRVEELVNVLKEKKIGVVAHFYMDPEVQGVLTAAQKHWPHISISDSLVMADSAVTMAKAGCQFITVLGVDFMSENVRAILDQAGFEKVGVYRMSDETIGCSLADAASAPAYLNYLEAASRSPPSLHVVYINTSLETKAFAHELVPTITCTSSNVVQTILQAFAQMPELTVWYGPDSYMGANIVKLFQQMTLMTNEEIANIHPKHSLDSIKSLLPRLHYFQEGTCIVHHLFGHEVVERIKYMYCDAFLTAHLEVPGEMFSLAMEAKKREMGVVGSTQNILDFIKQKVQEAVDRNVDDHLQFVLGTESGMVTSIVAVIRSLLGSSANSKLKVEVVFPVSSDSMTKTSSDSSNSIKVGDVALPVVPGVAGGEGCSIHGGCASCPYMKMNSLSSLLKVCHKLPDLENVYGGFIAERFKRQTPQGKLIADVGCEPILHMRHFQANKELPDKLVHQVLSCESKR
Protein: Replication factor C, subunit 5, putative (Q38AG5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Replication factor C, subunit 4, putative
- Proliferating cell nuclear antigen
- Replication factor C, subunit 2, putative
- Replication factor C, subunit 3, putative
- Chromosome transmission fidelity protein 18 homolog
- Checkpoint protein HUS1
- Replication factor C, subunit 1, putative
- DNA polymerase eta
- DNA primase large subunit
- Sister chromatid cohesion protein DCC1
Sequence:
MLWVDKYRPRTLDDVDLYPELTEVLKRLAESQDLPHLLLYGPSGTGKKTRAMAVLQQVYGPSVYSLRLEHKSVQVTDSKVVDIATLSSPHHIDINPSDAGNHDRVVVMQMIREIAQTVPLQSGTPGAAKYKVVVLNEVDKMGRAAQHALRRTMEKYMATCRLVLICNSTSRLIAPLRSRCLAVRVPSHSQENITKVIRTVCEKEGRMPPSPAFLAALSNQSEGNLRRAQLMLEAAAMTKVDFSGSGANIPQADWQVFLEEIANDILTEQTPKKLFEIRGKFYDLLGQCISGEVIMRGVLEALLNSVKPAMRPAVVSLAAKYDHNMKLGTKPILHLEAFASGVMQLLKRN
Protein: Cop9 signalosome complex subunit 12 (P47130)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 26S proteasome complex subunit SEM1
- Protein THP3
- COP9 signalosome complex subunit 9
- Nuclear mRNA export protein SAC3
- Cop9 signalosome complex subunit 11
- Cell division control protein 31
- SAGA complex subunit SUS1
- Cop9 signalosome-interactor 1
- 26S proteasome regulatory subunit RPN3
- Nuclear mRNA export protein THP1
Sequence:
MDVDIGCYFEEKRYDDKLLDFIRYDVKTPKKTKYILQRPTATDEESVRLQRFYQLGVDLKLKYSKRRSLKKQGRIKNATEELLRLANEQLKLFNRIVERETNWIIYPLWVMAKQLIRLANESSELNKDSIEECGRTIHRSFTICLNDRNPRLNENKKIGCYMFANLEFSIYHRLSNKDMIKNLVKVLESRVNARDIPPLNKSLAMEHKSQVVLYNYYLGQYYGCLENDHERGFFHLNEALLQCPMLYVESTGKFVLQGQMEKIMILLVPLALLTKRLYPHWDHPVIAGVITRSKRLSQVYPTLVRSVISGNLSLYEATAASHERFFLSQGLHVVITLLREVVFTRLVQRCWQWGNDRKSIMPLKILLATKQHDSSANEDEEEQLDALECRLASAIASGLLRAYLSHSNRCIVFSKKEPFPHSK
Protein: Pre-rRNA-processing protein TSR2 homolog (Q9VBI0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein eS26
- Ribosome production factor 2 homolog
- RNA-binding protein NOB1
- RNA polymerase I subunit F
- FI04466p
- Probable ribosome biogenesis protein RLP24
- Pre-rRNA-processing protein TSR1 homolog
- Glutamate-rich WD repeat-containing protein 1
- FI08810p
- Ribosome biogenesis regulatory protein
Sequence:
MAAAQQTEFQKNFRVIVEKIFNHWQDLRLAVEHGMGGRNGQQVAIEIMDYTYQYCVSNENITQGELVEVLEELMDQEFNTLCDDDSIPEICRNLLRYKLMAQQNQFPQIEAELSKLPAGKEWLRPDVKITYTPIDGDSSSDEDMDDSDEEDDNEMGQGDEETPSGSGRMTRSQARKQQAEEFVEPEDGWTTVRRK
Protein: Uncharacterized protein (Q587H8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL3m
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Mitochondrial RNA binding complex 1 subunit
- 50S ribosomal protein L17, putative
- 50S ribosomal protein L16, putative
- AB hydrolase-1 domain-containing protein
Sequence:
MYQRTRFLWSSWRDYPLGSRDRRGRFNMDEAAAALQLNPAYAAALYRPLNYTFHIRGQLYPAQKGRPSRPGSLAASQGRMFPLYQRNDRLDKELFRLNSRGLTTE
Protein: Oxidation protein CepF/oxidation protein CepG (OxyB protein) (Q70AY8)
Organism: Actinoplanes teichomyceticus
Interaction partners:
Sequence:
MSGDGSPPIHTRRQGFDPADELRAAGTLTKISIGSGADAETTWLAAGHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRDDQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLTSLLVAW
Protein: Protein NUCLEAR FUSION DEFECTIVE 4 (F4I9E1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable sugar phosphate/phosphate translocator At2g25520
- Metal tolerance protein C1
- Guanine nucleotide-binding protein-like NSN1
- BTB/POZ and TAZ domain-containing protein 3
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- At4g34150 family protein)
- Protein POLLEN DEFECTIVE IN GUIDANCE 1
- Tetratricopeptide repeat
- Subtilisin-like protease SBT4.10
Sequence:
MRPRIRDVSDKLRPNRASFDDGETKFHRKHLPPLRTMFGRWRKWTVLVAAIWIQASTGTNFDFSAYSSHLKSVLGISQVRLNYLAVASDLGKAFGWSSGIALGYFPLSVVLFAAAAMGFVGYGVQWLVITNIITLPYSLVFLCCLLAGLSICWFNTACFILCIRHFPNNRALALSLTVSFNGISAALYSLAFNAINPSSSNLYLLLNSLVPLVVSFAALYPVLTKPSLDTTPDYDSRRHDSHVFTILNVLAVITSFHLLLSSSSTSSARLNFIGAVVLLVFPLCAPLLVYARDYFLPVINARLNHESSGYVMLNIDELKNQKTSVSSKTGYEHMGTAKEGNTVRLGDEHSFRLLISRLEFWLYYIAYFCGGTIGLVYSNNLGQIAQSLGQNSTTLVTIYSSFSFFGRLLSAAPDFMHKRFRLTRTGWFAIALLPTPIAFFLLAVSSSQQTALQTATALIGLSSGFIFAAAVSITSDLFGPNSVGVNHNILITNIPIGSLLYGYIAASIYEANASPDITPIVSDSIVCIGRDCYFKTFVFWGCLSILGVVSSLSLYIRTKPVYHRLEQDKVSLTSSYKDLDPL
Protein: TNF receptor associated factor 2 (B1AMX7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCC
Protein: Olfactory receptor 10D3 (Olfactory receptor 224-9) (Olfactory receptor 958) (Q8VEY3)
Organism: Mus musculus (Mouse)
Function: Potential odorant receptor.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEIKNCSVVTEFILLGIPHTEGFETLLFVLFLPFYACTLVGNVSILVAVISSTRLHTPMYFFLGNLSVFDMGFSSVTCPKMLFYLMGLSRLISYQDCVSQLFFFHFLGSIECFLYTVMAYDRFAAICHPLRYSVIMNSKICVALAVGTWLLGCFHSSVLTSLTFTLPYCGPNEVDHFFCDIPAILPLASADTSLAQRVSFTNVGLVSLVCFLLILLSYTRITISILSIQSTEGRQRAFSTCSAHLIAILCAYGPIITIYLQPTPNPMLGTVVQILMNLVGPMLNPLIYTLRNKEVKIALKKILHGKGSVSEG
Protein: Albumin (C9JKR2)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
Protein: Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (Intestinal guanylate cyclase) (P23897)
Organism: Rattus norvegicus (Rat)
Function: Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P25092}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25092}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P25092}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25092}. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. {ECO:0000250|UniProtKB:P25092}.
Interaction partners:
- Guanylate cyclase activator 2B
- Guanylin
- Inosine triphosphate pyrophosphatase
- cGMP-specific 3',5'-cyclic phosphodiesterase
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
- Molybdenum cofactor biosynthesis protein 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase
- Phosphodiesterase
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
- Phosphodiesterase
Sequence:
MTSLLGLAVRLLLFQPTLMFWASQVRQKCHNGTYEISVLMMDNSAYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDRKMGCVLMGPSCTYSTFQMYLDTELNYPMISAGSFGLSCDYKETLTRILPPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLLFGHMLQTFLENGESVTTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPGLGPQILMIAVFTLTGIVVVLLLIALLVLRKYRRDHELRQKKWSHIPSENIFPLETNETNHVSLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYTLSCRDQNEKIFRVENSYGTKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTPPTVENQQRLQTEFSDMIVSALQKRQASGVKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF
Protein: Photosystem II reaction center protein J (PSII-J) (P12189)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01305}.
Interaction partners:
- Photosystem II reaction center protein L
- Photosystem II reaction center protein I
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein T
- Os08g0433350 protein
- Cytochrome b559 subunit alpha
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein H
- Photosystem II reaction center protein K
- Photosystem II D2 protein
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: Fanconi anemia group I-like protein (F4K4R1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Fanconi anemia group D2 protein
- AT5G65740 protein
- Protein TIFY 4A
- Protein TIFY 4B
- Fanconi-associated nuclease 1 homolog
- Holliday junction resolvase
- AT3g05090/T12H1_5
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
Sequence:
MTVAAAAEEPSQRPLTDKDIIRLAQYHHCQTGFSLPPYLLSPSSHDSLLSYLKSRSSSPSPSKQVSEYVIALLSLISLSPTTPSLCSLLASLLISYTQIFNSCKIPSDSDSLKTIQLFGTLLRYLHVKEVKSVVDSILSGVTRVITVDEAQVFDLLPVCFDLLRREGKASEIDFVNSAIDRVLSCEWNKALLTKMVSLAKEFSFLDKGRKSELVEKVFVGIKLIDLQDLPSLVYQLLVLASKGFCKREVIGGVVGYFGSKAETRVASVVRQIEGTVLLHVNFAVKQDPSLGQEVVALVKSDLRAFNHFTVAVLFSVARVRKFGESSLGMLRTALLTAYNDYRLSKDCKWLPVELKEESFLHAKLVEKSLLRAVSECRYGREHVVPSVIQFGFMLLESVEEGRSNEFGDSKGVLGIEKLSIQILGTLFEVHDMTRNEIIEQCKFRILSLKCAKSKPIVRLLGYLVQRYSLIMLEFVHHLKELLDYFTFMEGHISCFLVSAVIPLIKFSRDLQDYTILVIRKAMFRREDTVRVAATKVITDLILAEKLAKRDSSFTFQDSASQASSSQQTEMSCIVRGNLFTELNGLLQRCLYQQARVKEVVYDGLVKLVLIDPSSGGHVLDFLMPHFLRFFGQDTDFQLGITSCIRVEGDKFTIEEPLDRLLFCVSWILLLQQQNSSDRPSDAAWPCFGFSLSQDNEQQVGRNLSHEAYSSALVKIRSFLLGKKLGDIVGQSQDTVSASLEEDKRKSYCLIILGIVQVLLNYIIVDLEKQPEGKKGSVRKEIVDLIDLYESLEKDVGKSKQSNVGKRVRFSACNDTDLGNTSINEEREKVPFLATSSIYQLFLLSFKLYSSKSVGTQSGSQDHSHSSPAKTEKSIFSFTLHVCVGHINSSLCMKEENPLKPLVCGDMKVLGPPLLKVVYLLKPEPPLATGQTNKEKKGRKDVDGRKQCLHLALLSLKELLNIYSSGSGLTGLLEDLLAVPASEDATLEECREASKIEDPLIKSIEIFMAKIMKPMITDFIAQNSNDVEEAKTIIFNCTVQILCDIMLKLGNNLPDKFKQRHGSWAHQICRSCETSNTTVAKSVLKLAISFTTSPGDLCIAVEVAQELQNIMGLDKSDTLEVSESYMVINQSTSASVTSCILQSIDSAIVDMDWATKKLKNFYVVSQKNIHLSDDTESTVGSVLEEALYSMAESTVRILSSFVLMNLKESQAAQFLRLAVRFYKQLAQIVKLRIAPKGCKQILPSLKFQKLVELTCKSLTVPLYPFLSEMQKVKVVQAVITLMFLRIQKREVLLLFQIQEQQESVSHNSKGIINKIKQENKCIPDLIFQIEDCERYLIQLSKVTKLNLLRHAKRSTARDFKIIEDSDPPAGGEDGGNQEEETETQNNNIGEDDLRQESDDDGSEEMLSPRNASSVSSPGLDSDKTIAAATEEDDEEEQEQDEGEEESGDNRPKKMARKSWVVEDSDEDSETF
Protein: Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2) (Q9UKL6)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53808}.
Interaction partners:
- Acyl-coenzyme A thioesterase 13
- StAR-related lipid transfer protein 5
- StAR-related lipid transfer protein 4
- StAR-related lipid transfer protein 3
- StAR-related lipid transfer protein 6
- Sodium-coupled neutral amino acid transporter 5
- Ceramide transfer protein
- Steroidogenic acute regulatory protein, mitochondrial
- Paired box protein Pax-3
Sequence:
MELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKKTGLYEYKVFGVLEDCSPTLLADIYMDSDYRKQWDQYVKELYEQECNGETVVYWEVKYPFPMSNRDYVYLRQRRDLDMEGRKIHVILARSTSMPQLGERSGVIRVKQYKQSLAIESDGKKGSKVFMYYFDNPGGQIPSWLINWAAKNGVPNFLKDMARACQNYLKKT
Protein: Myosin 1 light chain cam2 (Calmodulin-2) (O14008)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:17202724}. Prospore membrane. Note=Accumulates at the cell poles in interphase cells and at the medial septation site in post-mitotic cells, colocalizing with myo1 and F-actin patches. During the mating process, a single dot is detected a the tip of the mating projection. During meiosis I, dots disperse into the cell periphery and the cytoplasm. At metaphase II, intense signals appear near meu14 rings which are formed at the leading edge of expanding forespore membranes. Localization is dependent upon myo1 with the exception of the localization to mating projections. {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:17202724}.
Interaction partners:
- Myosin-1
- Calcium-channel protein cch1
- Actin
- Calmodulin
- Calcium/calmodulin-dependent protein kinase type II
- Peptidyl-prolyl cis-trans isomerase
- Tubulin beta chain
- Calcium/calmodulin-dependent protein kinase type I
- Calcineurin subunit B
- Serine/threonine-protein phosphatase 2B catalytic subunit
Sequence:
MPASKEQTDEMKEAFVLYDIDKDGLIPTSHVGSVLRSLGINVTDAELAKLSNELGDAIDEKKFMSFVSNKLRETESEEEYIKAFRVFDKDNSGYIETAKFADYMKTLGEKLSDNEVQLMVQEADPTNSGSFDYYDFVQRIMAK