wanglab/gogpt-training-data huggingface dataset:
Protein: PH and SEC7 domain-containing protein (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for Arf 6) (E1JIT7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Guanine nucleotide exchange factor for Arf6. Regulates axon growth and branching by inhibiting microtubule polymerisation at the cortex. Together with shot, promotes axonal microtubule bundle integrity. Required for normal ethanol-induced tolerance and preference. Probably by activating Arf6, counteracts ethanol-induced sedation.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:31718774}. Cytoplasm {ECO:0000269|PubMed:31718774}. Cell membrane {ECO:0000269|PubMed:31718774}; Peripheral membrane protein {ECO:0000269|PubMed:31718774}. Cytoplasm, cell cortex {ECO:0000269|PubMed:31718774}.
Interaction partners:
- ADP-ribosylation factor 6
- Rho GTPase activating protein at 18B, isoform C
Sequence:
MSEELKVVLRRSEQHSGFGFSLLGTTGPPHVIYDIVENSPAADCGAVEAGDVILKVNGTDVHRYTTKEVLKCLRLSEQLVTLELKRDPKLKARIKEQLANTQSPHYVDIESPNIYDYHSSSTNSSPNHRPNAGGKGAATTPSQTGLRYKSPTHLPSLRQNSSPLLASGSTTTTTTATHTHSHSRNSSASSTKIKVVETSITTSTTNVVGLTSPTGSVGGGVGGEATSPTFRPSRIPQALTKCAVPKPVPVLHSPQNKRPRPSQIPTKAANGNGNGHTAHLPPQSLQHSNSYSGSPVTRQRFADREPEREPEPNSAPPQPAKAPRFEAYMMTGDLILNLSRTPQTSNPLPAQAKKIDSLRDSPSRLVNPRINGALAPRASGESSPTSSSSVDSPTNTSSDSVKREAKLLQKQQQQQQQTYQQQQQRDSINNSYNRKDSLTNDTLLMCEELEPDEEGEYVLEEDNKQQRQRQQQQRYRQQQNQQRYEYYQNEDELEEQEEVEEEREEDQTHYDITNIETYQSGVGRGDDDDSDRQCLVDDDDDDDAYDDEENDAGDEDYSTNSLGSGSAKQRLRALKQRTATRQQQRNRDAVDCAGRSGSGSSSTTVKSEAGGLGLDETSFSVPTSPISLSTPLIDKETANSVPTSPEPSSLVPESSSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPIDIDEDVNSSLNTLLDTRQDSEDSQSMATVIVNNSSLASNNNEGEQTDNRSSSSSSNSSDNNNCSSNTGEPATSETATATATIITATSTRTMNCSSKLNYILCKKASDRDRIVWTYNAPLQPHQLAALQRQQQQQEQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQQSHSNSHSSSISSSPQHSAVGSPASPTSVSSSVMSSSGSKGALGLGSSSNGPMAAVQQQQLREREQGGQVAQPPSGIPGLLSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDILGGMVLSDPSDSDSTILVSDAAAHQRQQLKQQLRAQQQQQRERERDRDRDREQSEHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVESLHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEEAGDLQQQRANNSALGNVGLNPFLDPPELATAVEYKKGYVMRKCCYDSSFKKTPFGKRSWKMFYCTLRDLVLYLHKDEHGFRKSQMSDNLHNAIRIHHALATKANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSWVETINYVCAAISAPPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLDSHEVQLAQLDQELNEHKKGPIPSKGLALQNYKEKESYLQYELRRYRTYVSILSAKMLADQQQLELQAQQPSPASHEEEADTFPVGTTACTPPTPQSINQKDQQKEQQQQQPTNRKEKKKK
Protein: Ribosome biogenesis protein Nop10 (P81303)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
Interaction partners:
- Probable tRNA pseudouridine synthase B
- Large ribosomal subunit protein eL8
- Uncharacterized protein MJ0782.1
- Translation initiation factor 2 subunit alpha
- DNA-directed RNA polymerase subunit Rpo11
- KH domain-containing protein MJ0443
- tRNA pseudouridine synthase A
- DNA primase small subunit PriS
Sequence:
MVEMRMKKCPKCGLYTLKEICPKCGEKTVIPKPPKFSLEDRWGKYRRMLKRALKNKNKAE
Protein: LIM domain-containing protein (Q501W5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLGVSEMTGSNMANALANASCERCKSGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPDCFCCDICQAVLADVGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIEEQPLIFKNDPYHPDHFNCSDCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCYHCNRVIEGDVVSALNKAWCVNCFSCSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK
Protein: Cortactin (Q1RMR3)
Organism: Bos taurus (Bovine)
Interaction partners:
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
- Dynamin-2
- Cofilin-1
- Tyrosine-protein kinase
- Cofilin-2
- Actin-related protein 2
- Protein deacetylase HDAC6
- Dynamin-1
- Actin-related protein 3
Sequence:
MWKASAGHTVSITPDDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQVDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQSDRVDKSAVGFDYQGETEKHGSQRDYSRGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKPQLHESQKDYKTGFGGRFGVQSERQDSCAVGFDYKEKLAKHGSQQDYSKGFGGKYGVQKDRMDKNASTFEDVAAVSSSYQKTVPVEAVNSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAQERQEQEAARRQLDEQARAQKPTPPASPTPQPAQERPPSSPVYEDAAPFRAEPSPSREPELGYSVETTEYPEAYVSEGVYESTEAPGHYRAEEGTYDEYENDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGLCKGRYGLFPANYVELRQ
Protein: Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5) (Q925E0)
Organism: Mus musculus (Mouse)
Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane.
Interaction partners:
- Dystrophin
- Utrophin
- Dystrobrevin alpha
- Beta-1-syntrophin
- Alpha-1-syntrophin
- Beta-2-syntrophin
- Dystrobrevin beta
- Dystroglycan 1
- Delta-sarcoglycan
Sequence:
MSAEGSQSLAAPRGRPSHLLVPARTKTALALLYDEGLENAYDVRLKLTKEVLTIQKQDVVCIGGAPPGANHRTVTLRRQPVGGLGLSIKGGAEHGVPVVISKIFKDQAADQTEMLFIGDAVLQVNGINVENATHEEVVHLLRNAGDDVTITVEYLREAPSFLKLPLGSPGPSSDHSSRASSPLFDSGLHLNGHCSHTAPSSPSSPIANEPKYEKRWLDTLSVPLSMARISRYKAGTEKLRSSALEVLALDGASTGVLQFSTAQDCADWLRSISTNISDLTLQHMKMANKCCSPCDQVVHMGWVNERLQGADNSQNFRPKFLALRGSSFYIFGAPPVSTLDWGRAERAYNLCEVLFKVHKFWLSDNYWLQANLYLGLQDFDCEDPRSYCFSVLANHGKSHIFSVELGSELAVWEKAFQRATFMEVQRTGSKTYLCSWQGETLCFTVDFALGFTCFDGKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDTKQIETKELEFQDLTAVLHCIHSFIAAKVASLDPVFMDSQSMARRYLCSS
Protein: Metallo-hydrolase/oxidoreductase superfamily protein (Q682P6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGNLKLALIIKSPRDDVEFLLEKQKQPAKFGDEAYDSFVDSDLWDLPSTDLQALEDGVRSGFSISILDSCSEEVDLMNFDFESTLILLLENLGIDISDVGEWRFVRSVEEPEFGPDSCVRTCFISGKLLNTDQSLQDNCKWMSMESCFDSLIDVKLGSDRVGPLVLLGLGDGSRQSMKHKLSSSLAIQEYPPGVMIVPMHSKTLKPFRTTNLVVFAPENGLGDHQGADFVAHGDALIVDPGCLSKLHVELKKIVDALPRKLIVFVTHHHRDHIDGLSAIQESNPDAILVAHAKTRHRIGGWSGNYTPVSGGENIYVNGQKLTVIFAPGHTDGHMSLLHTSTQSLIVGDHCVGQGSAFLDIRAGGNMTDYFQSTYKFLELSPNVVIPMHGRVNLWPKHMLCGYLKNRRSREKSILKATVDGAQTLYDIVAKVYSSVDRKFWWAASSNVRLHIEKLAVENKLPEGFSIQKFKASCGLRFAIRCTVGYIISKIPFKINKPGFIMSVMAAGAGYFLLYTSKKKNQIES
Protein: Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) (Q58AU6)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAAEGHNVDANLVDMRPNHGHYFVKKTFGKPAYCHHCCDKIWGMLTTGYSCEMCNFVCHEKCLRTVVSYCSSVALQLIKNPVAHTWSAPCLIKRKYCCVCRKRTDDALSVECEVCEYYVHVDCSDLAVSDCKEAATYVANMESANTVQYHHMREGNLPKESKCIVCRKTCFSTECLAGMRCEWCGQTAHAVCYRQMDKECDFGVLRKIMLPPMCLTIPRTELPMEQLLNISSHDQPQSLSSPSKIQADDVSTSGEDVKEREDFEIIRVFDGNNSYRSQDSLRRYHVVRFYVQEKEDPHDHAVFVGNLPVSLAQRQYERILLKLLGAKEKPFTAIGPIYFEYGSLIITFNTPKAATAAVQKLQSAIYEEKKLIVLCLPNVQPQMIPKDVEPLLVLVNVKSGGCQGTELIQSFRKLLNPFQVFDVLNGGPLVGLYVFRNIPKYKILACGGDGTIGWVLQCLDIAKQDAACFSPPCGIVPLGTGNDLARVLRWGGGYTGEENPMDILKDVIEADTVKLDRWAVVFHEEERNQPTSSGNQTEMNEQTMNNPEDQTSMIIMNNYFGIGIDADVCLKFHNKRDANPEKFQSRLFNKTQYAKIGLQKMFFERTCKDLWKRIELEVDGRIIELPNIEGIVVLNLLSWGSGANPWGTSKEEGNFSKPTHYDGLLEVVGISDVSRLGLIQSKLAAGIRIAQGGSIRITTHEEWPVQVDGEPHIQPPGTITILKSALKAQMLKKAKKSRRGGATNATSLTHPHPETSESMSGPLGVPSTLGDPNHGKTTPDNTAADSDEEGDAFL
Protein: Fatty acid binding protein 1-B.1 (Fatty acid-binding protein 1b, liver, tandem duplicate 2) (A0A0R4IRM6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Fatty acid-binding protein 10b, liver basic
- Brain-type fatty acid-binding protein b
- Fatty acid-binding protein 2, intestinal
- Adipocyte fatty acid-binding protein
- Fatty acid binding protein 11a
- Fatty acid-binding protein 3, muscle and heart
- Brain-type fatty acid-binding protein
Sequence:
MPFSGKFELEKYEGWEEFMTAIGHQELLKKANDGKTQFEIQENGNDYCLTTRSGGKVLNNSFTIGQDTEIQMLSGDKVKTVVHKDGQKLKAALGNITLTWELLDENTLLITLSTADNVAYKRFSKRVA
Protein: SFRS2 protein (Q6NXQ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGADPGVGAVPGLAADLATAARSLGPALVLDLGRPPSPDPHEGPSPSPRRSPDLVRGPGPGLGPGVLPQCPRGNPNPGRDRRVPPSLLKRKERCPLKKMLRSPV
Protein: GyrI-like small molecule binding domain-containing protein (Q7JPE4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFELAFIAVLVAGAVYVFMTLRKNGFFVTVEPSVTTSPKNLDKPLTVYYKYHLGPYQNVMNVIGEAKQLLASSPTPATFFGIYYDNPEVTDSHFLQSAVGVVFGSDGNDFHSEKYSKDLTDNGFEKLVLPNVERAVQVTQPSTGGFASFLALVWFTYSTIRKYISENKLETTYAVEFYTNTEINVIFPLDNANEFLVKDYQSIDKLESEAAKKRFDSSEEDSESEPEGAEEPATEENEQ
Protein: Adhesin (Q9U7F6)
Organism: Entamoeba histolytica
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endosome {ECO:0000256|ARBA:ARBA00004177}.
Interaction partners:
- Cysteine protease, putative
- Cysteine proteinase
- SNF7 family protein
- Cysteine protease 9
- Cysteine protease 8
- Cysteine proteinase, putative
- Cysteine proteinase, putative
- Cysteine proteinase, putative
- Cysteine protease 10
- Ubiquitin-like domain-containing protein
Sequence:
MNRQFIPEFPVIPMRKSDPADVTYAFTYALQNCVLEKKAILALQSLSQLRQQIISVEPCQQLRDVSWKYYQYLNQLSGRVTINLQFTWYDTYLQEDSKPKKFIYSTLDFEKANVMYNMGCCCMALGSSFSKTTDANSLKSAVQSFQQAAGAFQKAADCAQLCAAGSGDLHPRRLQTLTTLALGCAHLIMHINAVAQGKSESLQTKLAAAAANQLIPSVDAFKTFYKITVGFNFLSNFIIIKDYAIYCVQTLAAKGAEEKMEYGEQVKRLKWAMKAMYQACNIAYSSANKDALKKIYTEAKAAYTQAEKNNNNIYMNNLPRRRDLPPITEVLAAKPIELETIENLFDNILPANLSKALNEYNSKAQVILNDSKKVCESKTNEGNRIINSLKENSCDIPQDIIINANRLKQLNTYNSICQQMEFITTIEAETTASFEKGITALDSEAAEERRLRGQYPYQWKRTASEMAAYNYRRESEKYRASLKQAKSIDDNMINKFRQFENDIKLLCEGNIQQLFGTSNINIEQTEMKWKEIIQERQTALENMIKIYEKNEKEKVGVIKGGNGSNQCVINLLKEFDNTKNIIQQSLFKQNNLFREINNGNRSAAITGMVQRLRVAINAADEILKTLPQSIQFHRDAKNKIDTFQNECIKFQNQRQQEALSMVRSITGNSQPQQQPYSYGTNPMFPSL
Protein: Collagen alpha-1(II) chain (Alpha-1 type II collagen) (P02459)
Organism: Bos taurus (Bovine)
Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Interaction partners:
- Aggrecan core protein
- SRY-box transcription factor 9
- Collagenase 3
- A disintegrin and metalloproteinase with thrombospondin motifs 5
- Cartilage oligomeric matrix protein
- Collagen alpha-1
- Integrin beta-1
- Integrin alpha-1
- Integrin alpha-2
- Runt-related transcription factor
Sequence:
MIRLGAPQTLVLLTLLVAAVLRCHGQDVQKAGSCVQDGQRYNDKDVWKPEPCRICVCDTGTVLCDDIICEDMKDCLSPETPFGECCPICSADLPTASGQPGPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQMGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKSGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGAAGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGAGPAGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGSQGLQGARGLPGTPGTDGPKGAAGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGTAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGDPGLQGPAGPPGEKGEPGDDGPSGPDGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPIGKQGDRGEAGAQGPMGPAGPAGARGMPGPQGPRGDKGETGEAGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGQREKGPDPLQYMRADEAAGNLRQHDAEVDATLKSLNNQIESLRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPASVPKKNWWSSKSKDKKHIWFGETINGGFHFSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRAEGNSRFTYTVLKDGCTKHTGKWGKTMIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVCFL
Protein: Tegument protein UL46 (Tegument protein VP11/12) (P10230)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates host LCK and thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to activate the PI3K pathway by phosphorylating host AKT on its activating residues. This mechanism is inhibited by the viral protein US3 that instead promotes incorporation of UL46 into virions. Plays a role in the inhibition of TMEM173/STING-mediated type I interferon production. Interacts with host DOK2 and induces its degradation. This immune evasion mechanism to inactivate T-cells may play an important role during pathogenesis.
Subcellular location: Virion tegument {ECO:0000269|PubMed:18596102}. Host cytoplasm {ECO:0000269|PubMed:28592536}. Host cell membrane {ECO:0000269|PubMed:18452963}; Peripheral membrane protein {ECO:0000269|PubMed:18452963}.
Interaction partners:
Sequence:
MQRRTRGASSLRLARCLTPANLIRGDNAGVPERRIFGGCLLPTPEGLLSAAVGALRQRSDDAQPAFLTCTDRSVRLAARQHNTVPESLIVDGLASDPHYEYIRHYASAATQALGEVELPGGQLSRAILTQYWKYLQTVVPSGLDVPEDPVGDCDPSLHVLLRPTLAPKLLARTPFKSGAVAAKYAATVAGLRDALHRIQQYMFFMRPADPSRPSTDTALRLNELLAYVSVLYRWASWMLWTTDKHVCHRLSPSNRRFLPLGGSPEAPAETFARHLDRGPSGTTGSMQCMALRAAVSDVLGHLTRLANLWQTGKRSGGTYGTVDTVVSTVEVLSIVHHHAQYIINATLTGYGVWATDSLNNEYLRAAVDSQERFCRTTAPLFPTMTAPSWARMELSIKAWFGAALAADLLRNGAPSLHYESILRLVASRRTTWSAGPPPDDMASGPGGHRAGGGTCREKIQRARRDNEPPPLPRPRLHSTPASTRRFRRRRADGAGPPLPDANDPVAEPPAAATQPATYYTHMGEVPPRLPARNVAGPDRRPPAATCPLLVRRASLGSLDRPRVWGPAPEGEPDQMEATYLTADDDDDDARRKATHAASARERHAPYEDDESIYETVSEDGGRVYEEIPWMRVYENVCVNTANAAPASPYIEAENPLYDWGGSALFSPPGRTGPPPPPLSPSPVLARHRANALTNDGPTNVAALSALLTKLKREGRRSR
Protein: UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) (A0A1D8PNG6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Phosphoacetylglucosamine mutase
- chitin synthase
- chitin synthase
- Glucosamine 6-phosphate N-acetyltransferase
- chitin synthase
- chitin synthase
- Glutamine--fructose-6-phosphate aminotransferase
- mRNA-binding translational activator
- Protein transport protein SEC61 subunit alpha
Sequence:
MTVKSQHPIIDSFKQANQDQLFQYYDSLTINQQQEFIDQLSTIEEPAKLISTVEQAIQFSQTNSTSRNFTQLPNEQTASTLDLSKDILQNWTELGLKAIGNGEVAVLLMAGGQGTRLGSSAPKGCFNIELPSQKSLFQIQAEKILKIEQLAQQYLKSTEKPIINWYIMTSGPTRNATESFFIENNYFGLNSHQVIFFNQGTLPCFNLQGNKILLESKNSICQSPDGNGGLYKALKDNGILDDLNSKGIKHIHMYCVDNCLVKVADPIFIGFAIAKKFDLATKVVRKRDANESVGLIVLDQDNQKPCVIEYSEISQELANKKDPQDSSKLFLRAANIVNHYYSVEFLNKMIPKWISSQKYLPFHIAKKKIPSLNLENGEFYKPTEPNGIKLEQFIFDVFPSVELNKFGCLEVDRLDEFSPLKNADGAKNDTPTTCRNHYLERSSKWVIQNGGVIDNQGLVEVDSKTSYGGEGLEFVNGKHFKNGDII
Protein: Iron-sulfur cluster assembly protein 2 (AtISU2) (Protein ISCU-LIKE 2) (NifU-like N-terminal domain-containing protein ISU2) (NifU-like protein ISU2) (Q9MAB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:15792798, ECO:0000269|PubMed:17417719}.
Interaction partners:
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Frataxin, mitochondrial
- Cysteine desulfurase, mitochondrial
- Molybdenum cofactor sulfurase
- Molybdenum cofactor sulfurase-like protein
- Pyridoxal phosphate
- Pyridoxal phosphate
- Emb|CAB16785.1
- Pyridoxal phosphate
- Heat shock 70 kDa protein 9, mitochondrial
Sequence:
MMMLRQTSRKAYLGLQASPLGLGRRLYHENVIDHFENPRNVGSFNRNDPNVGTGLVGAPACGDLMSLQIKVDDSGQIIDTRFKTFGCGSAIASSSVASEWIKGKTLDEVMTIKNAEIAKHLRLPPVKLHCSMLAEDAIKSAVRDYKEKQAKTNAAAAEETVKA
Protein: G-protein alpha 12 (Guanine nucleotide binding protein (G protein) alpha 12) (Guanine nucleotide-binding protein (G protein) alpha 12a) (Guanine nucleotide-binding protein subunit alpha-12a) (Q5YKG4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Lysophosphatidic acid receptor 1
- Rho guanine nucleotide exchange factor
- Lysophosphatidic acid receptor 4
- Rho guanine nucleotide exchange factor
- Rho guanine nucleotide exchange factor
- Rho guanine nucleotide exchange factor
- C-X-C chemokine receptor type 4b
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Lysophosphatidic acid receptor 2b
Sequence:
MAGVVRTLSRCLLPAEAAHDDRSTGKDRTRERDVNREREAKRRSREIDSMLKRERRSIRRLVKILLLGAGESGKSTFLKQMRIIHGKEFDQKALLDFRDTIFENVIKGMRVLVDARDKLGISWQNSENEKHGMFVMSFENKAGMAVEPCTFQLYVPALQALWNDSGIQEAYGRRSEFQLSESVKYFLDNLDRIGQLSYVPSRQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFSNVSIILFLNKMDLLVEKVRKVSICKHFSDFRGDPHRLVDVQAYLVQCFNRKRRNRIKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ
Protein: Autophagy-related 16, isoform A (LP08352p) (Q95TJ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQYKSKDADKLNEENESIIRKRSAKLKRDLEDAVREPSSSSNAASSPGAASLQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSADGAIYIWNVNGFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYSES
Protein: Early transcribed membrane protein 8 (C0H4Z2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVFIFFAFVNFLFVLNLFSPCTCKKDYGKEWVKDKLSLVNLKLEKYDKKKKFALISGAAIGALALITLIGGIYMTKGRKSSIWHNSEINDTLYDVVLETVNQGNTDVKLAFQRGVKLDDAVPSEATFKKYLKQNIKDRNLNLTWQEERELYRMLPYIRFNVERLAVFLR
Protein: Anaphase-promoting complex subunit 6 (Cell division cycle protein 16 homolog) (CDC16 homolog) (Cyclosome subunit 6) (Protein NOMEGA) (B3DNN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 7
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 1
- Cell division cycle protein 27 homolog B
Sequence:
MREEEIEKIRGVVRDCVSKHLYSSAIFFADKVAALTNDPSDIYMQAQALFLGRHYRRAFHLLNASKIVLRDLRFRYLAAKCLEELKEWDQCLLMLGDAKVDDDGIVYDAKDGNVIDFDKDGEDREINISSAICFLRGKAYGALQNRSQARQWYKAAIKADPLCYEALECLIESHMLTSEEESSLLSSLQFSPEDGWLSSFYSCLIKKYDKESTVELKFKKLENETSGSVSGSSMITLANNTDLLACKAEYYHQCCEYQKCFELTAALLEKDPFHLKCTLVHLAAAMELGNSNELYLMACNLVKDYPSKALSWFAVGCYYYCIKKYAEARRYFSKATGIDGSFSPARIGYGNSFAAQEEGDQAMSAYRTAARLFPGCHLPTLYIGMEYMRTHSYKLADQFFMQAKAICPSDPLVYNELGVVAYHMKEYGKAVRWFEKTLAHIPSALTESWEPTVVNLAHAYRKLRKDREAISYYERALTLSTKSLSTYSGLAYTYHLQGNFSAAISYYHKALWLKPDDQFCTEMLNVALMDECQNGVDSKVELC
Protein: Sonic hedgehog protein (SHH) (EC 3.1.-.-) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)] (Q63673)
Organism: Rattus norvegicus (Rat)
Function: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
Subcellular location: [Sonic hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Sonic hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (By similarity). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides. {ECO:0000250|UniProtKB:Q62226}.
Interaction partners:
- Cell adhesion molecule-related/down-regulated by oncogenes
- Patched
- Patched 2
- Protein smoothened
- Hedgehog-interacting protein
- Brother of CDO
- Low-density lipoprotein receptor-related protein 2
- Growth arrest-specific 1.
- Protein dispatched homolog 1
- Hedgehog protein
Sequence:
MLLLLARCFLVALASSLLVCPGLACGPGRGFGKRQHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKARIHCSVKAENSVAAKSDGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSGPTPGPSPLFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEAAGAYAPLTADGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAPQSVAEARGAGPPAGIHWYSQLLYHIGTWLLDSETLHPLGMAVKSS
Protein: Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (Q38BA0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|HAMAP-Rule:MF_03061}.
Interaction partners:
- Diphthine--ammonia ligase
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L5, putative
- 40S ribosomal protein S18, putative
- Large ribosomal subunit protein uL5
- 40S ribosomal protein S15a, putative
- 60S ribosomal protein L17, putative
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S5, putative
- Ribosomal protein
Sequence:
MRRFCDVVFYPNRFYRLASSAFLKNIDKLRNIGISAHIDSGKTTVTERILFYTGRIDKIHEVKGGSEVGATMDSMELEKERGITIRSAATQCKWGDHLINIIDTPGHVDFTIEVERALRVLDGAVMLMCGVGGVQSQTLTVDRQMKRYGVPRVCFINKLDRDNANPRRALEMARERLGVNAAFIHLNMGVAQDFEGVVDVIESRAVYFDGKNGEKIRFEDIPSYIADDVVATRKELISRLADCDAEMEDVFLNDVEPTAEQIHSAIRRTTIANKFVPVLVGSAYKNKGIQLLLDAVCRYLPSPMEKPNSGYSVTKVKDDEGNVANVKGEIVPLATDDEKPLVAAIFKLEETKKTGLLNYIRVYQGKMRREHLMNVRSGKTFLPQKLVRMHANSTDQIDEVRAGDICAIQGEIDASSGDTIVKAGVTAGQLITCEDMYVPPRVISASVKINNDRDSSKLRERMGAFMREDPTFCFYRNTETNEDIVEGMGELHLDIYIERLKREYDLEVVLGKPTVNYREVITERKEFDFVYKRQSGGAGQWAQLKGFIDVLPIDMSVEKGVKNKVTVKCSNGDVREALQKSVVKQLERKIFVKGELMGAPVWGVHFHLSGGAMHEVDSTDLAFRNATQELWETLLPQLKPTLVEPYMVVEITVPSTCMTDVSTEFAKREGVVTETTISGTDAIIRGETALDTMFGFISDLRRLTKGQGDFGMQFKEYRPMQQYKAQCRMDERNKDLGRKLYRLSGQ