wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin-like protein (E9PSL8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin-associated protein 3
Sequence:
MVKQTIQIFARVKPSVRKQQQGIYSIDEDEKLASSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATVRHAKLHLVDLAGSERVSKTGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIADLKAELAMVTGEQRTEALTEAELLQLEKLIASFVEDQDPESRLEVGADLRKIHYCFHHFKKLLNDKKTLENTDSSESTTQQACQEPVKDEEYTKLRSLLKQRDNEINILVNMLKKEKKKTQDALQYSSTEKSEARPPPNSPFIAGSPAGQRTSFSSSLSQTQDLSVYRHRSSLLHKKTGMREEMSLGRQEAFEIFKRDHADSVTIEDNKQVLKQRFSEAKALGESINEARSKIGQLKEAISQRHLQQVALGIAESMAPPSTPDPQEQKLRAQLEEEKSRYKTTFMRLKALKVEIEHLQLLMDKAKLKLQKEFEAWWAEEASSLQVNSPATNLQDAAKPFPQQDQTQLLSKKSSQGLEVENGAGKLDVCGRNARRILPSPCPSPHSQEPSGSSIQLQDRPSSIPLTGDRQTDSDILAFIKARQSILQKKCLGSN
Protein: 7-cyano-7-deazaguanine synthase (EC 6.3.4.20) (7-cyano-7-carbaguanine synthase) (PreQ(0) synthase) (Queuosine biosynthesis protein QueC) (P77756)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
Interaction partners:
- 7-carboxy-7-deazaguanine synthase
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- S-adenosylmethionine:tRNA ribosyltransferase-isomerase
- GTP cyclohydrolase 1
- Epoxyqueuosine reductase
- NAD-dependent dihydropyrimidine dehydrogenase subunit PreT
- Queuine tRNA-ribosyltransferase
- Queuosine precursor transporter
Sequence:
MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPEADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVSLGMAKDIRFETPLMWIDKAETWALADYYGKLDLVRNETLTCYNGFKGDGCGHCAACNLRANGLNHYLADKPTVMAAMKQKTGLR
Protein: Shugoshin-1 (ZmSGO1) (Q4QSC8)
Organism: Zea mays (Maize)
Function: Plays a central role in chromosome cohesion during meiosis I by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for maintenance of centromeric cohesion before prophase II and correct segregation of chromatids during meiosis II. Has apparently no function in mitosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:15916952}. Chromosome, centromere {ECO:0000269|PubMed:15916952}. Note=Localizes to the centromere during meiosis I. REC8 is required for centromeric localization.
Interaction partners:
- separase
- Synaptonemal complex protein ZIPPER1
- Protein BRICK1
Sequence:
MTSTAAEGAGSGSLNPPHSNPSGDGGPRIRSPPGKGNKPVALADITNTGKPNAARSITVPDLVKENTKLLTLLNEKTKIIDLSRVEIYKLRLALQASKQQNLHLTQTNSQMLAEINTGKDRIKMLQHELSCTTALLKVKDSELDRKKNAGNVQQKGVKSQVLKTKASTVAVEAHHVGDSVTSGVEHHVVESQSAVSSNTVCQEPPQDGKQKRMPQRRRSSRLNQGSCEIRGVSQNTLHENPVVPVAPSTLSLEKQYGQTTGKHMKSLQNECSATVHEVIMASEFEKTEINELPQKTDLKEIPEACSSETEVQSHKIGDKAFNSKQNHLTGSQSSLSFNTVDTPEPPEDNTVKRCSKKRSSIEDVNAKLDTITSEPLRHEEKRKSRRKISARLNSVSSEHTDIVVETEHKDVIVSLAGSTSNVSMEQRTNQEQDGDCFSRKSNENQILGRRSLRRAAEKVVSYKEMPLNVKMRRP
Protein: Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) (A0A1L8HU22)
Organism: Xenopus laevis (African clawed frog)
Function: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: recruited to replication stress sites via interaction with ubiquitinated CMG helicase and acts by mediating DNA glycosylase activity. Cleaves one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TAT5}. Chromosome {ECO:0000269|PubMed:30842657}. Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase. {ECO:0000269|PubMed:30842657}.
Interaction partners:
- FPG_CAT domain-containing protein.
- RING-type domain-containing protein.
- Endonuclease III-like protein 1 lyase)
- CTP_transf_like domain-containing protein.
- Dephospho-CoA kinase domain-containing protein
- Dephospho-CoA kinase domain-containing protein
- FA complementation group I L homeolog isoform X1
- DNA polymerase theta
- POLAc domain-containing protein.
- DNA polymerase subunit gamma-1
Sequence:
MEALPPQVLKPLDCMSIYSRHREPENRHNELSTGRCGRGHVIFSSMKALQPQVLKPTGSHANLQQVLYAPAATIITAPASSHNDLSSLTGCSYAGVETLGKELFIYFGLKAMRVHFGMNGSMRINQPMKKGQENGRPIPIAVLEVQLTKDLICFYESTVDVRNASECQEKIRFFEELDVCSSKFSFPRAECEIKKQRTRMLCDILLDQMILPGVGNIIKNEALFDSGLHPGVQAGLLTDEQVSHLVKMTRDFTLLFYKCRKSGSALYKHYKVYKRPNCGQCGTKITVCRLGEHNRMTYFCPKCQKDKPQHVDVSKLPTRNSLIGWVQRTASNANEHVATSKEEHWACAVCTLINKPSDKQCDACLTLRPEVSSLAVSDEAAELNTDLVKYPCNNFAKVLPELKLNRRTAFGNTTLVLTDFGAKEGLADKNSQQNILNRSTFDVPLNNKYYHTKTPSNKRSNENEHWTNTLNAVNGHSAASNNVFNHPQKKLKTGHTTSNTIHLSSTISSPQSKMTGDAAAKTGNPQCSAHNVPCALQVVRKEGENKGRSFYTCSLPRERRCQYFEWADLHFPFCNHGKRCIVRTVLKIGPNNGKNFYVCPMGKDKQCNFFEWAKTE
Protein: Kinase suppressor of ras 1 (A0A8I6AAT0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDRAALRAAAMGEKKEGGGGGASAAADGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQSKLSVTPSDRTAELNSYPRFSDWLYIFNVRPEVVQEIPQELTLDALLEMDEAKAKEMLRRWGASAEECSRLQQALTCLRKVTGLGGEHKEDSGWSSAEARESSSGPSVDMLSSLGRAGASTQGPRSISVSALPASDSPVPGLSEGLSDTCIPLHTSGRLTPRALHSFITPPTTPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVAPMRFELPHGSPQLVRRDIGLPVTHRFSTKSWLSQVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPLARLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSPGQRDSRFNFPDISACPQAAPLSSTADSTRLDDQPKTDVLGVPEAEAEEPEAGKSEAEDDEDEIDDLPSSRRHWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREERRENQLKLSHDWLCYLAPEIVREMIPGRDEDQLPFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVKRVLASVSLGKEVGEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL
Protein: Armadillo-like helical domain-containing protein (Q54C50)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MESKIKSIKKKIEESNHFQIQRESVLLIYQLLQNEKSTQIFDSSVILFLQLIYNPNTHVIETTIECIINLIKDKKLNREFVLNKLIESISSLERGNVGIIVKVIILLSIDIEYMSKIIKETNNKGYSIFPLNTLTKQHALSKPEIYDSFSMEIEELLSDSNIPSSLLDQRFEFLKPLVSNLLLNINELPLETSLLHNSLIRIAHNISTLYQPILSHLSSLLYLYNNNNNNKNNKNNNGSYQKIQYIRDLIDLIRFPPQSSNQLNQCNEFQKSILSIIYYLMNVFISGFNEKEISIRNMALTQIQDLIELSPISTTLLWNQSSLNSSSQNLNTPVLVVLLLYLPSSLVCFQKKILNILQSSIESLSSIDLKQILKSSDSNKQVILHTLRLSLSPIIRIISNFNQQQQQQEQEQQLQNENLKKLLKQIETLIFTISTNIERNQEINSNQDIDDEDIEELIFNQSLPTLDIYLLDNFIPINLAWNLLMMNNNDSSSRSSNGGDGGDYLKYEIIPSWLEIIKFNILNQKEIIEEQEEEEKEKEKERKSLINKSNINFSNEFLIYFLSPFLFYKFNQQNEIASEIRIKTIHLLPSICRNSIESISLIPLFFFSIQREESSNVILDLLQSLPDLANNKECLNSVVKVLSILEQQTKKQQQQQQQQQQQQQQQQQQQQSSSNSKSSSSSIIMPSFLLRLYCKLLKSSPLIFTKIEELIYSIIKETTTTTTLSTIEIENKISAAITIKEICEFDSNLGQELIQPLSQFLCKDNDPTILSISLEALSSLCENEILSFTSAWNVIKKNLGQEESFEQDKRSPMVLCSLLDFFSRGGVCDLRGEQNLEQKTIDIISDIIRRIWNLTFVKNINLQDNNHHDDSNLNENNNNINLKVQSKAFETLGNFINAPLLNLELFEKIKSKVPHLLIILSKYQKNQESIDENLIYLLNSLLKNELTEKRSLKTAHQNLKQTKSISIFSSSSGSNNNCNKIFELLNNELINESRTGIKSGILGGLLWFNNDYDSQVTTQQQQQQQENNNNEIKKRVESKKEILINFKLNNQILNESIEYLDLSRDLLTKLMITLGGWNKFMNQCFQALKKNDLMRQSLPSGTKLSIKETNEKVFNEIETMLLKNINENGSTMVKGENSVYALISLAKTQSSICYSQMESIVNQLIQWITKPEEHFKNGENYQLIQSASYLGLGILLPHLLQDSPLIKESINILEFAATSSTSKLDSSIKFNCYLSLAICSLKLSSTKHQNEKKRINLIIYNSFLNYFDNSNNDVQHALNDHDPTSSMIFGGLCLAIGYCSDSFEQLSMSTQLSKIYEIIEKKLIRNQQFSIENNLAHNLLLISFPSIIGSCFKLSLINSNEILNNLIPTIYLNQDKQQQQQQQQQQSIYQCIGYNNLIQILLSKGFTGFDLSMIQQLLISNNKIMNDANNNYSTNVIINSVISTSILIGSPILTQSSQVLFESSLESSVLNFINSNPNSRKEFQSLLNEIIISMSNLFKSPNTDSKLIRYISICLGSITLSTTYNNNNNGLSGGEPENFDHLSNDLLIKALFNTLIDSTTSSTLNDLNLTTVESCLRILNQLNQNDSIKLPIVNWSTIIKRIYSKFRDNINIKKQCITFVSKNIKLSTLSIVMSEWLSLSNFNSESQSIQLKLIKSLPLVLNQLSPIRVNSIFDEIISNIILNDPFLIWNNVLNKLFNQNDQDDDQDDDDDDDDDDDDDDDDDQDDDYKDYNNNNEILLNEIKEIISRFMILNVKNLPSPFIKENEQLSSDNMKLLKIASKSLVHLSKEQLQQCLVLLSGIVDIDSEAKIQYLYVLVLANGNGPFGKVTLSNFYKIKSWCFSSTTAEQQSKVLSILPYILTKPLIENQNSFTFDSILNDIFDSITLTQRQHVIGLELLSQLISTQINNSIFEFNSFFNLYFNFDSNEIKYNQIKSICNTSISFRYLELLPYYLQVFYNGKLNNTINTTIKVTDFIGKLSSLLQNRSSVLGLKTKSIIFSSILTLNQLKFIDSSVNSANDNQLQQLNIFNLYKILKSSPSNNSN
Protein: [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) (A0A0C4DFL8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF
Protein: Protein BTN2 (Batten disease protein 2) (P53286)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: V-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi. Modulates the rate of arginine uptake. Involved in pH homeostasis. Required for the correct localization of IST2. May be involved in ion homeostasis together with IST2.
Subcellular location: Cytoplasm. Late endosome.
Interaction partners:
- Heat shock protein 42
- Protein SIS1
- Protein BTN1
- GTP-binding protein RHB1
- Heat shock protein 104
- Hsp70 nucleotide exchange factor FES1
- 30 kDa heat shock protein
- Curing of [URE3] protein 1
- J domain-containing protein APJ1
- Protein transport protein YIF1
Sequence:
MFSIFNSPCVFEQLPSFSQPLHSRYFDCSSPVSYYPECKRRKAIKANLRAPKKSDANCSEPLRYALAETPNGYTLSLSKRIPYELFSKYVNEKLGELKENHYRPTYHVVQDFFGNQYYVEDEADEDALLRSALKDLDFRAIGKKIAKDLFQDYEIELNHRGDELSILSKKDKIFKEFSLDQVFEDVFVIGCGVENIDDGSREKYALLKIGLVKHEEEISEGGINEPKMPIIESKIDESHDDVNMSESLKEEEAEKAKEPLTKEDQIKKWIEEERLMQEESRKSEQEKAAKEDEERQKKEKEARLKARKESLINKQKTKRSQQKKLQNSKSLPISEIEASNKNNNSNSGSAESDNESINSDSDTTLDFSVSGNTLKKHASPLLEDVEDEEVDRYNESLSRSPKGNSIIEEI
Protein: ENhancer of Uncoordination (O45607)
Organism: Caenorhabditis elegans
Interaction partners:
- ENhancer of Uncoordination
- Netrin unc-6
- Netrin receptor unc-5
Sequence:
MRILRILFSLVIFGLIVHVLPTTTTPNVPVSAATNTSNVTAPAGNSTKSPNATAPAGNSTKNVNVTALSANTTQLALVSSASPETCKNGNGTHCPSRTISFHKDTPKYIGCGILIAFVIFHIFLYFYLEDQKAREQKKYFEELIAEQMAARKREEQDEKQHEDEEMLCRLRIGVSKDRKREEQDDQQHEDEAPEAVVTVDKPRD
Protein: Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) (Q55DL0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Interaction partners:
- Beta-ureidopropionase
- Dihydropyrimidine dehydrogenase [NADP
- Multifunctional protein pyr1-3
- Bifunctional purine biosynthetic protein purD
- Protein transport protein got1 homolog
- Uridine 5'-monophosphate synthase
- Dihydroorotate dehydrogenase
Sequence:
MLRVDQTGTILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDKLLLPGGIDTHTHFQLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRGQSLLEAYDQWKKWADEKVNCDYSLHVAITWWSEQVSREMEILVKERGVNSFKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQVHAENGDMVFEGQKKMLEMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQSIGAADVICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRTKGVLMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMSIVWENGVNTGKLTWCQFVRATSSEAARIFNIYPRKGRIDVGCDGDIVIWDPNQSKTISKDTHHHAVDFNIFEGIKVTGIAVTTIVAGNIVWSDNKLSCVKGSGRFVPRPPFGPVFDGIEQRDKVRNELLRKVDRKPYEDDNTKNSSK
Protein: NR2C2 protein (Q6PHZ7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQTGQKIQIVTAVDASGSPKQQFTLTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSKRKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPGKICGGDA
Protein: EF-hand domain-containing protein (Q582G2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRPCGVQLAIPARLAAIVLGAAVFTFLLKGTLWGRPTKLAAGRNCERNNTPLGSPKRRRNKEGSLGCVEMFRRFLKKLGRTSAAEKVVAIRTAKSPDAEIYRLLLLEHQKQLGITFSVAIEEVPELSGELQIVVGPLEDYRRQTSNCSPFSTTAVTERERRVGGSEQLAKVEQLLVCRIKLPERRFCCNIPPFVMRVLAAQANNSLVFSTHAAEVLYCMPRIEEETREYQNKHLLNTQGEQKQKKYKRSGLTSSSPSLTLGKGAVVLGGSSRPTSNSTFGSLQDTLQSTPSCGSITIQSQLRVQGHETAVMQNLGENIDVNAVLFSTSLLVCGDSTSSGKVGPAFCCSVPNRVQEKDEPTHTAVREALLNTLFLVSPKGLNRGPLEKLRQNPLAVWRASRQSVLTTAMLYVIDVASANGDPMVCYSRVVDEVVAQAVLLHHDGMVLDFIGALSERFGKQYTPHCTVFQQAVESRREDHSRSGNVSFQVDSPNPCENLQNILEELPYICEFILEHRNDFSNAVLTPGGSNLLEEVFGVPATVFPFLPCARESIAFITQSFNCIVETYGSLSSEGFCEFRSDVLNESKADVMASSQRCFRELNNSRSGIISFEELCHWMARKLSSDNTLSNPDARLLSIAMSLGLPMALLLGTRQEWARLGRAPIFNGEGDQGCRLAHAT
Protein: 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) (O75832)
Organism: Homo sapiens (Human)
Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}.
Interaction partners:
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory subunit 6B
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 6
- Proteasomal ATPase-associated factor 1
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome regulatory subunit 10B
Sequence:
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
Protein: Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (A0A1B0GTB8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
Sequence:
MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWAELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLGGFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS
Protein: Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho) (Q5FA35)
Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Interaction partners:
- Transcription termination/antitermination protein NusG
- Transcription termination/antitermination protein NusA
- Polyribonucleotide nucleotidyltransferase
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- Membrane protein insertase YidC
- 30S ribosomal protein S1
- CTP synthase
- Ribosome maturation factor RimP
Sequence:
MHVSELQTLHISKLLELAEEHGIENANRFRKQDLVFAIVRQMMKKGEGFTCSGTLEILPDGFGFLRSADTSYLAGPDDIYVSPTQIRRFNLHTGDTIEGSVRVPKDNERYFALVRLDSINGDHPEVCRHKILFENLTPLFPTEQLKLERDLKSEENLTGRAIDLISPIGKGQRALLVAPPKIGKTVMLQNIAHAVTANYPEVELIVLLIDERPEEVTEMSRSVRGEVVSSTFDEPAQRHVQVAEMVLEKAKRMVEHKKDVVILLDSITRLARAYNTVVPASGKILTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALVETGSRMDDVIYEEFKGTGNMELHLDRRMAEKRLFPAININKSGTRREELLVPNDQLQRMWLLRKFLHPMDEIEATEFLNGKIKASKNNDDFFELMRGK
Protein: Middleman of seventy-eight signaling (A0MSJ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKEIDTETTVVWPAWCYSGNAPTDILQQKPAKATTAIVGGRSAAQPATHDDQEAATTASTATKRKHLERLASDLRQLGKKGRRSRSVSPCSRYPAVAETARMLSERSLLLSGYGAIESSAKKLSEAATGGAGGGGGGAAGQAATPTTSQLSAPASSASSSSMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKMDNHKDAPMVTIHNNNNNNTINNNNSSSSSIINNHQSSQPSLGHSVKRERLSPGSNSSSHNGELTVSSFARSRSATPSSSSYRGGGGGAGGGVSPSHQQQQQQQQQSLQQQQRLSPPSGPSMATATTTSSLSSSSSASASASASASAATHMPLHNLSTNLLNSIQQAAASQQQLRSSNSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAGGSNSAPSSALKSASSSTGSTTTTAKKLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSGGGGSSMSQLAPPPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQQRSGSNASSPSASAAGTPRSSSTLNAALHQAAQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDSTTVAPIGDGGGGSSIASAAPLDLSSQPPAAKRFKAERRASSTATTATTATTGSSTSTPSPPPLEQHDDINSGNANATLGTGSGTGTGESSAAGSGAGVAKARRRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGPALKLRSILAKKLGGPCPCVACVAQAQQMLALQTGGAAAAAAATAGAGTVTGAVAGAGATSATTSCSIKSEIFNGGSNGSSSGSSSNQGSDVAAPPAATASSPSSNMLLPVLPCSGLQDAS
Protein: UDP-glycosyltransferase 72E1 (EC 2.4.1.-) (Q94A84)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: UDP-glycosyltransferase that glucosylates coniferyl aldehyde to form coniferyl aldehyde 4-O-glucoside. Glucosylates sinapyl aldehyde to form sinapyl aldehyde 4-O-glucoside. Is not active in presence of coniferyl alcohol or sinapyl alcohol. Can glucosylate the phytotoxic xenobiotic compound 2,4,5-trichlorophenol (TCP).
Subcellular location: Nucleus {ECO:0000269|PubMed:24320620}. Note=Colocalizes with SIS8 in the nucleus. {ECO:0000269|PubMed:24320620}.
Interaction partners:
- Cytochrome P450 84A1
- F5F19.5 protein
- Flavone 3'-O-methyltransferase 1
- Probable serine/threonine-protein kinase SIS8
- Cytochrome P450 84A4
- UDP-glycosyltransferase 72E3
- UDP-glycosyltransferase 72E2
- Peroxidase 13
- Aldehyde dehydrogenase family 2 member C4
- Peroxidase 71
Sequence:
MKITKPHVAMFASPGMGHIIPVIELGKRLAGSHGFDVTIFVLETDAASAQSQFLNSPGCDAALVDIVGLPTPDISGLVDPSAFFGIKLLVMMRETIPTIRSKIEEMQHKPTALIVDLFGLDAIPLGGEFNMLTYIFIASNARFLAVALFFPTLDKDMEEEHIIKKQPMVMPGCEPVRFEDTLETFLDPNSQLYREFVPFGSVFPTCDGIIVNTWDDMEPKTLKSLQDPKLLGRIAGVPVYPIGPLSRPVDPSKTNHPVLDWLNKQPDESVLYISFGSGGSLSAKQLTELAWGLEMSQQRFVWVVRPPVDGSACSAYLSANSGKIRDGTPDYLPEGFVSRTHERGFMVSSWAPQAEILAHQAVGGFLTHCGWNSILESVVGGVPMIAWPLFAEQMMNATLLNEELGVAVRSKKLPSEGVITRAEIEALVRKIMVEEEGAEMRKKIKKLKETAAESLSCDGGVAHESLSRIADESEHLLERVRCMARGA
Protein: Protein RecA (Recombinase A) (Q9A9A7)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
Interaction partners:
- LexA repressor
- DNA polymerase I
- DNA helicase RecQ
- DNA repair protein RadA
- DNA polymerase IV
- Cell division protein FtsZ
- Protein ImuB
- Beta sliding clamp
- UvrABC system protein B
- DNA 3'-5' helicase
Sequence:
MTSQAALKLVAKEEGDKQRALEAALAQIDRAFGKGSVMKLGEKGKVEIESVSTGSLGLDIALGIGGLPKGRIVEVYGPESSGKTTLALHVVAEVQKAGGTAAFVDAEHALDPSYAYKLGVNLDNLLVSQPDNGEQALEITDTLVRSGAVDIVVVDSVAALTPKAEIEGEMGDSLPGLQARLMSQALRKLTASINKANTIVIFINQIRHKIGVMYGSPETTTGGNALKFYASVRLDIRRTGSVKARDEIVGNNVRVKVVKNKVAPPFREVEFDIMYGEGISKLGEVIDLGVKAGIIDKAGSWFSYGSQRIGQGRDNVREFLKNNPDVAADIEKAVRKSSQKIEEELLVGGPEEGEED
Protein: Peptidase A1, pepsin (A1S3N8)
Organism: Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Interaction partners:
- Acetyltransferase
Sequence:
MSKRIIELKLTNLLAEGGYTACLRLGSEAQSVNLIIDTGSSTLVVHESGYKAGNDKELKPTTLAQEVNYGLGGWLGAVVHTSIHAGELAMADTPLALVHAEAEHTFLDADGIWGMAYHPLNRGYDLTTYLTSHGIDPASTFPWPFPDEAHPLVKQQLDDFKALLPQLPEEDVATCFTLMEERGLCANRFTLITRRSSIHVTAPNACANTLAADPLNQGLLILGSHAADAAPNHGCAVDLKVVHDRYYNVNLKAVRWQNDTDIALPTAQAAHLCRGSSNAIVDSGASLICLPAVAFTPLMQRLWARLPDSKQLTSPFMGDISQIMAAQKQGIDSSLLNLDDWPRLEFVFEGANGENVCLGVDAHHYWQVNAPDYGKAVFKLMGQLPHWPAQSILGLPLFNPYRVVFRRDLGEQGIVRFIPHPPLSQGPVSQSPLNQNPINQSKAMP
Protein: AMOT protein (A2BDD9)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
Sequence:
MPRAQPSSASYQPVPADPFAIVSRAQQMVEILSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNCQPTNVSEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGLLSHSSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGTESNKTAAVAPISVPAPVAAAATAAAITATAATITTTMVAAAPVAVAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAVAPSAAAAAAVQVAPAAPAPVPAPALVPVPAPAAAQASAPAQTQAPTSAPAVAPTPAPTPTPAVAQAEVPPASPATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMVEYLI
Protein: Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) (Q96MB7)
Organism: Homo sapiens (Human)
Function: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:18339812}. Cytoplasm {ECO:0000269|PubMed:18339812}. Note=Interaction with NAIF1 promotes translocation to the nucleus.
Interaction partners:
- Nuclear apoptosis-inducing factor 1
Sequence:
MAIPITVLDCDLLLYGRGHRTLDRFKLDDVTDEYLMSMYGFPRQFIYYLVELLGANLSRPTQRSRAISPETQVLAALGFYTSGSFQTRMGDAIGISQASMSRCVANVTEALVERASQFIRFPADEASIQALKDEFYGLAGMPGVMGVVDCIHVAIKAPNAEDLSYVNRKGLHSLNCLMVCDIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHKDSWLLGDSSFFLRTWLMTPLHIPETPAEYRYNMAHSATHSVIEKTFRTLCSRFRCLDGSKGALQYSPEKSSHIILACCVLHNISLEHGMDVWSSPMTGPMEQPPEEEYEHMESLDLEADRIRQELMLTHFS
Protein: Putrescine N-methyltransferase 1 (NaPMT1) (EC 2.1.1.53) (Q93XQ5)
Organism: Nicotiana attenuata (Coyote tobacco)
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (By similarity). Methyltransferase that mediates the conversion of putrescine to N-methylputrescine (By similarity).
Interaction partners:
Sequence:
MEVISTNTNGSTIFKNGAIPMNGYQNGTSKHQNGHQNGTSEHRNGHQNGISEHQNGHKNGTSEHQNGHQNGTSEQQNGTISHDNGNELQLLGSSNSIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPSIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPINPIDKETTQVKSKLAPLKFYNFDIHKAAFILPSFARSMIES