wanglab/gogpt-training-data huggingface dataset:
Protein: Protein FAR1-RELATED SEQUENCE 7 (Q9M8J3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription activator involved in regulating light control of development.
Subcellular location: Nucleus {ECO:0000269|PubMed:15591448}. Note=The nuclear localization is independent of the light treatment.
Interaction partners:
- AT-hook motif nuclear-localized protein 14
- Histone acetyltransferase subunit NuA4-domain protein
- At3g18035
- AT-hook motif nuclear-localized protein 9
- Protein FRIABLE 1
- Flowering-promoting factor 1-like protein 1
Sequence:
MVVKTYPLGMVGTNNGIAENEGDSGLEPYVGLEFDTAEEARDYYNSYATRTGFKVRTGQLYRSRTDGTVSSRRFVCSKEGFQLNSRTGCPAFIRVQRRDTGKWVLDQIQKEHNHDLGGHIEEAQTTPRPSVQQRAPAPTKLGISVPHRPKMKVVDEADKGRSCPSGVISFKRFKGAEDSDGQTQPKATEPYAGLEFNSANEACQFYQAYAEVVGFRVRIGQLFRSKVDGSITSRRFVCSKEGFQHPSRMGCGAYMRIKRQDSGGWIVDRLNKDHNHDLEPGKKNAGMKKITDDVTGGLDSVDLIELNDLSNHISSTRENTIGKEWYPVLLDYFQSKQAEDMGFFYAIELDSNGSCMSIFWADSRSRFACSQFGDAVVFDTSYRKGDYSVPFATFIGFNHHRQPVLLGGALVADESKEAFSWLFQTWLRAMSGRRPRSMVADQDLPIQQAVAQVFPGTHHRFSAWQIRSKERENLRSFPNEFKYEYEKCLYQSQTTVEFDTMWSSLVNKYGLRDNMWLREIYEKREKWVPAYLRASFFGGIHVDGTFDPFYGTSLNSLTSLREFISRYEQGLEQRREEERKEDFNSYNLQPFLQTKEPVEEQCRRLYTLTIFRIFQSELAQSYNYLGLKTYEEGAISRFLVRKCGNENEKHAVTFSASNLNASCSCQMFEYEGLLCRHILKVFNLLDIRELPSRYILHRWTKNAEFGFVRDVESGVTSQDLKALMIWSLREAASKYIEFGTSSLEKYKLAYEIMREGGKKLCWQR
Protein: Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) (Q99536)
Organism: Homo sapiens (Human)
Function: Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).
Subcellular location: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria. {ECO:0000250}.
Interaction partners:
Sequence:
MSDEREVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAASPPLLRCLVLTGFGGYDKVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYDRLPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSVQTFLIPEAMTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVFGTASASKHEALKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLLKPMGKVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSGVVARLLALYNQGHIKPHIDSVWPFEKVADAMKQMQEKKNVGKVLLVPGPEKEN
Protein: LexA repressor (EC 3.4.21.88) (Q8Y7H7)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- Protein RecA
- DNA polymerase IV
- Lmo1301 protein
- Lmo2676 protein
- Cell division suppressor protein YneA
- DNA repair protein RecN
- 3'-5' exonuclease DinG
Sequence:
MKISKRQQDIYEFIKSEVKEKGYPPSVREIGEAVGLASSSTVHGHLARLEGKGLIRRDPTKPRAIEILSLEDEAETPNVVNIPIIGKVTAGMPITAIENIDEYFPLPEYMAAGETNVFMLEIDGESMINAGILDGDKVIVRQESSAINGEIVVAMTDENEATCKRFYKEANHFRLQPENDALEPILLNNVTILGKVIGLYRDIR
Protein: Peroxiredoxin 2540-2 (EC 1.11.1.15, EC 1.11.1.7) (RE05093p) (RH69586p) (Q7JX87)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Peroxiredoxin-5
Sequence:
MRLGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAHSVDALNSHVDWVNDIKSYCLDIPGDFPYPIIADPTRDLAVSLGMLDEEQKKDPEVGKTIRALFIISPDHKVRLSMFYPMSTGRNVDEILRTIDSLQLTDRLKVVATPANWTPGTKVMILPTVTDEEAHKLFPKGFDKVSMPSGVNYVRTTDNY
Protein: L-carnitine dehydrogenase/betainyl-CoA thioesterase (CDH thioesterase) [Includes: L-carnitine dehydrogenase (CDH) (L-CDH) (EC 1.1.1.108); Betainyl-CoA thioesterase (EC 3.1.2.33) (Betainyl-CoA thiolase)] (D7UNT2)
Organism: Rhizobium sp
Function: Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. Despite a high similarity to 3-hydroxyacyl-CoA dehydrogenases, cannot dehydrogenate 3-hydroxybutylate and 3-hydroxybutyl-CoA. Is probably involved in a L-carnitine degradation pathway that allows Rhizobium sp. YS-240 to grow on L-carnitine as the sole source of carbon and nitrogen.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20530902}.
Interaction partners:
Sequence:
MSFITKAACVGGGVIGGAWVARFALAGIDVKIFDPHPEAERIIGEVMANAERAYAMLTMAPLPPKGKLTFCKSIEEAVEGADWIQESVPERLELKRGVITKIDAAARPDALIGSSTSGLLPSDLQSEMHHPERMFVAHPYNPVYLLPLVELVGGKKTSKATIERAMQGVEQIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICHTETLDNVMRYSFGMRWAQMGLFETYRIAGGEAGMRHFLAQFGPCLKWPWTKFTDVVDLDDALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKSGNGGEGWGAGKLLADFEAKLWANARKPEADLGDVKPLRILDTKVSAAWVDYNGHMTEHRYLQVFGDTSDGVLRLIGVDLDYVRDGHSYYTVETHIRNLGDEASGEALYSTCQILSSDEKRLHIFSTIYNAATNEAVATAEQMMLHVDSKAGKAVAAPEAVLSKLRAITEAHAQLQTPDGAGRFVGQKRA
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (Somatomedin) (F2X2F1)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MGKISSLPTQLFKCCFCDFLKQVKMPITSSSHLFYLALCLLAFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKYQPPSTNKKMKSQRRRKGGPKKRPGGEQKEGTEASQQMQGKMKEQRRETGARN
Protein: LD31474p (NADH dehydrogenase (Ubiquinone) 20 kDa subunit, isoform A) (NADH dehydrogenase (Ubiquinone) 20 kDa subunit, isoform B) (NADH dehydrogenase (Ubiquinone) 20 kDa subunit, isoform C) (Q9VXK7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Complex I-49kD
- NADH dehydrogenase 23 kDa subunit
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 8
Sequence:
MLRSAMMSSTLSRALQKATQTPNASISALPALNLALVRQQQTLPVAEVAQNLPKKGYSPFGTKQSSVAEWSLARLDDLLNWGRKGSIWPLTFGLACCAVEMMHIAAPRYDMDRYGVVFRASPRQADVIIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIIPVDIYVPGCPPTAEALMYGVLQLQKKVKRMKTLQMWYRK
Protein: Small ubiquitin-related modifier 2 (SUMO-2) (Q6DHL4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- SUMO-conjugating enzyme UBC9-A
- Si:ch1073-55a19.2.
- SUMO-conjugating enzyme UBC9-B
- SUMO-activating enzyme subunit 1
- SUMO-activating enzyme subunit 2
- E3 SUMO-protein ligase PIAS4-A
- SUMO-specific peptidase 5
- Protein inhibitor of-activated STAT, 1b.
- FinTRIM family, member 52, pseudogene.
- RING finger protein 4
Sequence:
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLTMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGHRI
Protein: Putative ion channel POLLUX-like 1 (Q8VZM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- ABC transporter G family member 32
- NADPH-dependent thioredoxin reductase 3
- Protein TIC 40, chloroplastic
Sequence:
MVAVQLFTWKPLILPSQALTRDRLASFHRSLSLHSLPLGGIKSSSFRGTFKVKSQRTGDTEPPNKNFKDLNSKFYKSLPYKLVIGCIPLYAVLRIAQKIFQELPNLIQNSVKAGLPFACASNAIDKHPLLKAIPSSHDIKWGLARSSYLFNTQLEKNLGTVFVVLLITCFSFVIIGGLFFFKFRKDTSLEDCLWEAWACLVNADTHLEQKTRFERLIGFVLAIWGIVFYSRLLSTMTEQFRYHMKKVREGAHMQVLESDHIIICGINSHLPFILKQLNSYQQHAVRLGTTTARKQTLLLMSDTPRKEMDKLAEAYAKDFDQLDILTKSCSLNMTKSFERAAACMARAIIILPTKGDRYEVDTDAFLSVLALEPIQKMESIPTIVEVSSSNMYDLLKSISGLKVEPVENSTSKLFVQCSRQKDLIKIYRHLLNYSKNVFNLCSFPNLTGMKYRQLRLGFQEVVVCGILRDGKVNFHPNDDEELMETDKLLFIAPLKKDFLYTDMKTENMTVDETDDTRKQVYEEKKSRLEKIITRPSKSLSKGSDSFKGPKESILLLGWRGDVVNMIKEFDSYLGPGSSLEILSDVPLEDRRGVDQSIATGKIKNIQVSHSVGNHMDYDTLKESIMHMQNKYEKGEEDIRLTIVVISDRDLLLGDPSRADKQSAYTLLLAETICNKLGVKVHNLASEIVDTKLGKQITRLKPSLTFIAAEEVMSLVTAQVAENSELNEVWKDILDAEGDEIYVKDIELYMKEGENPSFTELSERAWLRREVAIGYIKGGKKIINPVPKTEPVSLEMEDSLIVISELEGDQVITL
Protein: Early growth response protein 4 (EGR-4) (Early response protein NGFI-C) (Nerve growth factor-induced protein C) (NGFI-C) (Q00911)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
Subcellular location: Nucleus.
Interaction partners:
- Neuronal PAS domain-containing protein 4
- Ngfi-A binding protein 2
Sequence:
MLHLSDFSGPDALLSKPTEGCAHTSPELPRLPARDAPSAAAYPGGDFLSWALSTCGAGGDLTDSCFLEGPAPTPPSGLSYSGSFFIQAVPEHPHDPEALFNLMSGILGLAPFPSPEAAASRSPLDVPFPAGPDALLPDLYSPDLSSAAFPEAFWEAAPSAGAPSQCLFEPQLSPPDVKPGLRAPPASPALDAAASAFKGPYAPWELLSAGAPGNCGSQGSFQTTPEARFSAVGTKVEDLLSISCPAELPGPASRLYPPGAYDAFSLAPGDLGEGTEGLPALLTPPGGEGGSGGEGGEFLAVPQAQLSPLGLRGAATADFSKALVADLPGGSGVAAPSSPATSFPAAKARRKGRRGGKCSARCFCPRPHVKAFACPVESCVRTFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFAAL
Protein: Smooth, isoform U (A0A0B4K8A1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPIKEIGNGRSPLLQEPLYGTRPQPYSKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN
Protein: Protein TWIN SISTER of FT (TFL1-like protein) (Q9S7R5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May form complexes with phosphorylated ligands by interfering with kinases and their effectors.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- UPF0235 protein At5g63440
- MADS-box protein SOC1
- Protein FLOWERING LOCUS T
- Protein GIGANTEA
- Small ribosomal subunit protein mS29
- Protein LEAFY
- Large ribosomal subunit protein mL46
- At1g64880
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL23m
Sequence:
MSLSRRDPLVVGSVVGDVLDPFTRLVSLKVTYGHREVTNGLDLRPSQVLNKPIVEIGGDDFRNFYTLVMVDPDVPSPSNPHQREYLHWLVTDIPATTGNAFGNEVVCYESPRPPSGIHRIVLVLFRQLGRQTVYAPGWRQQFNTREFAEIYNLGLPVAASYFNCQRENGCGGRRT
Protein: Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) (O88984)
Organism: Rattus norvegicus (Rat)
Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9UBU9}. Nucleus speckle {ECO:0000250|UniProtKB:Q9UBU9}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9UBU9}. Nucleus envelope {ECO:0000250|UniProtKB:Q9UBU9}. Cytoplasm {ECO:0000250|UniProtKB:Q9UBU9}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q9UBU9}. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles. Nucleus; nuclear rim. {ECO:0000250|UniProtKB:Q9UBU9}.
Interaction partners:
- NTF2-related export protein
- mRNA export factor
- Aly/REF export factor
- THO complex subunit 5 homolog
- Serine/arginine-rich splicing factor 3
- Nuclear pore complex protein Nup98-Nup96
- NTF2-related export protein 2
- Eukaryotic initiation factor 4A-III
- RCG43312)
- UPF3B, regulator of nonsense mediated mRNA decay
Sequence:
MADEGKSYNEHDDRVSFPQRRKKGRGPFRWKCGVGNRRSGRGGSGIRSSRFEEDDGDVAMNDPQDGPRVRFNPYTTRPNRRRDTWHDRDRIHVTVRRDRAPQERGGAGTSQDGTTKNWFKITIPYGKKYDKMWLLSMIQSKCSVPFNPIEFHYENTRAHFFVENATTASALKAVNYKIQDRENGRISIIINSSAPPYIVQNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRGCMAAALRIIEENIPELLSLNLSNNRLYKLDDMSSIVQKAPNLKILNLSGNELKSEWELDKIKGLKLEELWLDRNPMCDTFLDQSTYISTIRERFPKLLRLDGHELPPPIAFDVEAPTMLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSTPSNPQNPVRHNLAKYFNDSRNVKKIKDTTTRFRLLKHTRLNVVAFLNELPKTHHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASPEEIQRAFAMPAPTPSSSPVPTLSQEQQDMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK
Protein: Integral membrane protein 2 (Q9VPT9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU367061}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU367061}.
Interaction partners:
- GH25507p
- RH72958p
- MIP04261p
Sequence:
MTILGKLRGQPTDQEKVPLPMNLNDEALMHHGSLIAPKVAYSDNEADAESMVFNRPQHHCIKSFLLFLIAVVVMLLGVLGGWTLYRVYAPSHSSMRYHALCEIPYPEDSMEMARVYPRTVEPFALNWRSLLPELAQPMPNSGSLDESHFREDIELDGDSDDEGYARVDVPDFKDGRRGRFMHDFKENQSAIIDTTTGRCFIMPLDRDTTLPPTSFVDLIKKMSTGYYNIDTERVRRQMRVVMPRITDVSLISERIANECFDMKVYMMEKFVSGVSKRSADPLPESAKYAEFMGKGVIEYDLANIAEVEAYEANEARQQA
Protein: Probable cardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41) (Q8MZC4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UJA2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tafazzin
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phosphatidate cytidylyltransferase, photoreceptor-specific
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Lysophosphatidylcholine acyltransferase
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
- Trifunctional purine biosynthetic protein adenosine-3
- Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Sequence:
MLPAIIFRQVQRPLHHGAATLEHVLGVGGSSFVNCLNRYAAATGFIRISFLDIKRRRNYELARLRLYADEKKQSLHLRTLQGRHLLQGVIERKNFLVDDIREARHKVQERVREKIDEIREERENIMTIPNMLTISRAVLSPYIGYVIVQGDFTLGMSLLAFAGITDLLDGQIARRWPSQASKFGSFLDPMADKLLMGSLVISLCYTDLLPMWLMGIVVFRDVFLLGAGFVIRYISLPPPKTFSRYFDATHVTAQLEPTLLSKINTGVQLATIGLSLGAPIWNYLDHPALQGLWYLTGLTTAATALSYVMNRHNTFKIIQKKT
Protein: Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II) (P22532)
Organism: Homo sapiens (Human)
Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Subcellular location: Cytoplasm.
Interaction partners:
- Small proline-rich protein 2E
- Cornifin-B
- Small proline-rich protein 2F
- Small proline-rich protein 2A
- Late cornified envelope protein 3D
- Small proline-rich protein 2G
- Late cornified envelope protein 3E
- Cornifin-A
- Small proline-rich protein 3
- Late cornified envelope protein 1B
Sequence:
MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPSPKCPQPCPPQQCQQKYPPVTPSPPCQPKCPPKSK
Protein: UDP-glycosyltransferase 71D1 (EC 2.4.1.-) (Flavonol 3-O-glucosyltransferase UGT71D1) (EC 2.4.1.91) (O82383)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses quercetin 3-O-glucosyltransferase activity in vitro.
Interaction partners:
Sequence:
MRNVELIFIPTPTVGHLVPFLEFARRLIEQDDRIRITILLMKLQGQSHLDTYVKSIASSQPFVRFIDVPELEEKPTLGSTQSVEAYVYDVIERNIPLVRNIVMDILTSLALDGVKVKGLVVDFFCLPMIDVAKDISLPFYVFLTTNSGFLAMMQYLADRHSRDTSVFVRNSEEMLSIPGFVNPVPANVLPSALFVEDGYDAYVKLAILFTKANGILVNSSFDIEPYSVNHFLQEQNYPSVYAVGPIFDLKAQPHPEQDLTRRDELMKWLDDQPEASVVFLCFGSMARLRGSLVKEIAHGLELCQYRFLWSLRKEEVTKDDLPEGFLDRVDGRGMICGWSPQVEILAHKAVGGFVSHCGWNSIVESLWFGVPIVTWPMYAEQQLNAFLMVKELKLAVELKLDYRVHSDEIVNANEIETAIRYVMDTDNNVVRKRVMDISQMIQRATKNGGSSFAAIEKFIYDVIGIKP
Protein: Tetraspanin-15 (Q9XVM9)
Organism: Caenorhabditis elegans
Function: Plays a role in cuticle biogenesis. In complex with doxa-1 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dual oxidase 1
- Dual oxidase maturation factor 1
- Peroxidase mlt-7
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin
Sequence:
MGALGDSAYGARGRLIKFSYIVTALISILFSISCICYGIWLLARRSQYAELVSPSLYVDVGRILVIISILSILNYLICFYAIFKEMRCFVTSCAVASIVIAVMLIIGGCIGLNFRDQLTHYTPLNLKMLTSLRELYGTHDMKGITESWDALQSNFKCCGVNGTDNAQIWKTSKWYMHQRAPKLLIPESCCIPSEIERCRSNPFDQDAPPPYYTSTCYEPLQNDLLHVMNVASWLCITNAIVQIIPSVAGCWYSKLIRK
Protein: Gonadotropin-releasing hormone receptor-1 (B9P4N3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSGNVSLSLISLLENSSLASSSSPQSPQWETPTFTTAARYRVVATLVLFVFAAVSNLSVLISVTRGRGRHLASHLRLLIASLASADLVMTFVVMPLDAIWNITVQWYAGDAMCKLLCFLKLFAMHSAAFILVVVSLDRHHAILHPLEALDAGRRNRRVLLAAWILSVLLASPQLFIYRALKAEGVDFVQCATHGSFRHRWQETAYNMFHFVTLYVFPLLVMSFCYTRILVEINRQMPRGKGKGGEPCLRRSGADMIPKARMKTLKMTIIIVASFVVCWTPYYLLGIWYWFQPRMLQVTPVYAHHALFVFGNLNTCCDPVIYGFFTPSFRADITSCFSRRNQNCSPKSLDRLSARRGGASGEAESDPGSGDQPSGQTA
Protein: cAMP-dependent protein kinase regulatory subunit (Protein kinase A, regulatory subunit) (Rapid development protein C) (P05987)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit
- Developmentally-regulated protein kinase 1
- Protein kinase 2
- Probable serine/threonine-protein kinase DDB_G0277449
- RAC family serine/threonine-protein kinase homolog
- Probable serine/threonine-protein kinase DDB_G0286841
- Probable serine/threonine-protein kinase DDB_G0280717
- Probable serine/threonine-protein kinase DDB_G0288795
- Protein kinase 4
- 3',5'-cyclic-nucleotide phosphodiesterase regA
Sequence:
MTNNISHNQKATEKVEAQNNNNITRKRRGAISSEPLGDKPATPLPNIPKTVETQQRLEQALSNNIMFSHLEEEERNVVFLAMVEVLYKAGDIIIKQGDEGDLFYVIDSGICDIYVCQNGGSPTLVMEVFEGGSFGELALIYGSPRAATVIARTDVRLWALNGATYRRILMDQTIKKRKLYEEFLEKVSILRHIDKYERVSLADALEPVNFQDGEVIVRQGDPGDRFYIIVEGKVVVTQETVPGDHSTSHVVSELHPSDYFGEIALLTDRPRAATVTSIGYTKCVELDRQRFNRLCGPIDQMLRRNMETYNQFLNRPPSSPNLTSQKS
Protein: Inosine-adenosine-guanosine-nucleoside hydrolase (O15727)
Organism: Trypanosoma brucei brucei
Interaction partners:
Sequence:
MAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLTKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGEGKPCAHVARNPSKQMFHDLVFASTRVY
Protein: E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) (O00257)
Organism: Homo sapiens (Human)
Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
Subcellular location: Nucleus {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:19266028}. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). {ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:22467880}.
Interaction partners:
- Chromobox protein homolog 8
- Polycomb complex protein BMI-1
- E3 ubiquitin-protein ligase RING2
- E3 ubiquitin-protein ligase RING1
- Polyhomeotic-like protein 1
- Chromobox protein homolog 2
- Polycomb group RING finger protein 2
- Polyhomeotic-like protein 3
- Polyhomeotic-like protein 2
- Polycomb complex protein BMI-1
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
Protein: Repulsive guidance molecule A (Repulsive guidance molecule BMP co-receptor a) (Q1LVM8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
- Neogenin
- Neogenin 1b
- receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- receptor protein serine/threonine kinase
- Dragon
- RGM domain family, member D.
- Serine/threonine-protein kinase receptor
- Receptor protein serine/threonine kinase
Sequence:
MHSKRERRGALSRAGWMVMGKGAGPSALQVCQFLALFLSLFPAATLQCKILKCNSEFWASTSSSGPEEEFCTALRAYNSCVRRTARTCRGDLAYHSAQHGIEDLMSQHNCSKEGPTTQPRARTVPPPVLSPPQTDIHIPSDEPEVCHYERSLPHNAAPPNYTHCGFFGDPHLRTFNDDFQTCKVEGAWPLIHNKYLSVQVTNTPVVVGSSATATSKLTIIFNSFQECVDQKTYRAETEDLPAAFIDGSKNGGEGHGANTLRVVEKVPGQHVEIQARYIGTTIVVRKVGHYLTFAVRMPEEVVNSVEDQDNQDLYLCLHGCPANQRIDFRTFKARAAESHGVGRGRPGNPSHGFTYQSAMAKCKERLPVEDLYFQSCVFDLLSSGDINFTLAAYYAFEDVKMLHSNKNKYHLFEKDTIFNSASRKLAFSVLIFISFVIVQLWTDSCFICL
Protein: Uncharacterized protein (Q57TU6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAAAPAELILQELDAVLHRANKTQSELYQRVAVIGERIRSRQVLTRADELTQLARADILRRCRAIQQGRNKLLQTLRHAASLLATGDVNNLCGRSNTDAVLSTINEAAQVEHSLSRWQQPSLNIEAWRNVVSSGPQDDMAMERLLHPSGPRSGGDGNELPGWIYVPCICSIVDYCRVKKMPSAPGGSCGGSSGNGKRKAKGDNSLEEGHRGGEEASDVDGFGSNSEDVAKESKIALLMLQAAATAVDELIQRTEDEQTAAVGNGTSKCTDEEEEEAKEKAVEEKRLRVCIEIAAKAAAYTHAVKALSAGEDSALFDGVSDAAATVASLVSLPSSSAASLTHGVPVELLVLPPMESLFYCIAYTVGAAILRDEQNELRLTAPGTAGLGGGGEVGNYTESDGGDRGGSCATASAVACNEEEEVAPLDGITAGWRGDWEMWLQRSSGADCSFLGPRLLQYLLEYVFFPTGSAGHVGTVSVAPEAMRRWLMLACGGEAGVDGTVDTMMSLFMGQ