wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphatidylinositol transfer protein SFH5 (PITP SFH5) (SEC14 homolog 5) (P47008)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10848624, ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:14562095}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16709158}; Peripheral membrane protein {ECO:0000269|PubMed:16709158}. Microsome membrane {ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:16709158}; Peripheral membrane protein {ECO:0000269|PubMed:16709158}.
Interaction partners:
- SEC14 cytosolic factor
- Phosphatidylinositol transfer protein CSR1
- Phosphatidylinositol transfer protein PDR17
- Phosphatidylinositol transfer protein PDR16
- Phosphatidylinositol 4-kinase STT4
Sequence:
MKFDNDSEKQVFDKLKKAIPGIIKEKCAGYDELYGYKLNPEGLTQEEVDKYYDEKIADRLTYKLCKAYQFEYSTIVQNLIDILNWRREFNPLSCAYKEVHNTELQNVGILTFDANGDANKKAVTWNLYGQLVKKKELFQNVDKFVRYRIGLMEKGLSLLDFTSSDNNYMTQVHDYKGVSVWRMDSDIKNCSKTVIGIFQKYYPELLYAKYFVNVPTVFGWVYDLIKKFVDETTRKKFVVLTDGSKLGQYLKDCPYEGYGGKDKKNNLTKQNVTNVHPTEYGLYILQKQIIEDVE
Protein: ATP synthase subunit a (O21786)
Organism: Oryza sativa (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU004450}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004450}.
Interaction partners:
Sequence:
MNFDHNHVVIMGLNQRDSIWKLLNDYNVNSLKRRRQAEIDAFFEPFERAQRIRFNNWQNGIELLDGAEWRNGDIFIPGGGGPVISSPLDQFFIDPLFGLDMGNFYLSFTNESLSMAVTVVLVPSLFGVVTKKGGGKSVPNAWQSLVELIYDFVLNLVNEQIGGNVKQKFFPRISVTFTFSLFRNPQGMIPFSFTVTSHFLITLALSFSIFIGITIVGFQRHGLHFFSFLLPAGVPLPLAPFLVLLELISHCFRALSSGIRLFANMMAGHSSVKILSGFAWTMLFLNNIFYFIGDLGPLFIVLALTGLELGVAILQAHVSTISICIYLNDAINLHQNE
Protein: GM02712p (Q95SD3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRKQARQRREYLYNKALTERLKSKQKIQETVVKSINENKAIGSKNVKKSLTAYKSLKYADEGVDDRTVNDEYHYAGCEDPKIMLTTSHNPSSRLKMFMKELRLIIPNAQQMNRGNYQLTTLMHACRANNVTDFLIVHEHRGILDSLVVCHLPYGPTAFFNISDVVMRHDIPDIGHMSEQKPHLIFNNFKTPIGLRTVKILKHLFPVPKENSQRVMSFLNHNDSIIFRHHQYKYVNKELELTEVGPRFSLKLYQIKLGTLENIKAADTEWINRPYMNTSQKRLIFSNDPGIINKDTEA
Protein: N-acetyltransferase domain-containing protein (O16486)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein MAK10 homolog
- Sm domain-containing protein
- N-alpha-acetyltransferase daf-31
- N-alpha-acetyltransferase 16, NatA auxiliary subunit
- N-terminal methionine N
- N-terminal methionine N
- PID domain-containing protein
- Probable small nuclear ribonucleoprotein E
- N-alpha-acetyltransferase 20
- Probable small nuclear ribonucleoprotein-associated protein B
Sequence:
MAIGVQKKTSTPLDVGTEQEPTNLEKTIGTLRRCLQIAGTSNKPGSRSAKNSISEESNDLTMEESVPEASKWPHCQHMISQDEAPRNDELASPNIRIVAYKDESQINDIMRLITKDLSEPYSIYTYRYFLHNWPEYCFLAYDQTNNTYIGAVLCKLELDMYGRCKGYLAMLAVDESCRRLGIGTRLVRRALDAMQSKGCDEIVLETEVSNKNAQRLYSNLGFIRQKRLLKYYLNGGDAFRLKLIFTSRRVRSLNNQENYQPRCRVNEDDTPDEEEGTY
Protein: Sulfurtransferase TusD (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein D) (P45532)
Organism: Escherichia coli (strain K12)
Function: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Protein TusB
- Protein TusC
- Sulfurtransferase TusE
- Sulfur carrier protein TusA
- tRNA-specific 2-thiouridylase MnmA
- Cysteine desulfurase IscS
- Uncharacterized protein YheO
- tRNA sulfurtransferase
- Protein YchN
- Iron-sulfur cluster assembly scaffold protein IscU
Sequence:
MRFAIVVTGPAYGTQQASSAFQFAQALIADGHELSSVFFYREGVYNANQLTSPASDEFDLVRAWQQLNAQHGVALNICVAAALRRGVVDETEAGRLGLASSNLQQGFTLSGLGALAEASLTCDRVVQF
Protein: Hematopoietically expressed homeobox (Q9VDF0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MDIATKSSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNLGSGSRCGQQSDEEDRMYLSEDDEDDDEDEGEADETPK
Protein: Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Q97PR0)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00534}.
Interaction partners:
Sequence:
MTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTAFFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITDIEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGFMKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTELLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPTFVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDELGMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP
Protein: Mediator of RNA polymerase II transcription subunit 32 (Mediator of RNA polymerase II transcription subunit 2) (Q84VW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 10a
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 9
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 15a
- Mediator of RNA polymerase II transcription subunit 22a
Sequence:
MDNIVDSLNKAYEKFVLASAGVLESKESAGGQKALLTDTALENFKEKWELFRVACDQAEEFVESVKQRIGSECLVDEATGLTTTAAGGQAPAAVTGAATSLPPISAVRLEQMSRAVRWLVLELQRGSGVAPGSVHSSSTGFDSRFSEDSTQ
Protein: (2Z,6E)-farnesyl diphosphate synthase (EC 2.5.1.68) (Short-chain Z-isoprenyl diphosphate synthase) (Z-FPP synthase) (Z-FPPS) (Z-Polyprenyl diphosphate synthase) (Z-isoprenyl diphosphate synthase) (P9WFF5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11004176}. Cell membrane {ECO:0000269|PubMed:11004176}.
Interaction partners:
- 
- 
- Geranylgeranyl diphosphate synthase
- Decaprenyl diphosphate synthase
- Isopentenyl-diphosphate Delta-isomerase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1
- Nonaprenyl diphosphate synthase
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase
- Dimethylallyltranstransferase
Sequence:
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRSYGR
Protein: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 (B0R0K2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Potassium voltage-gated channel, subfamily H
- Potassium voltage-gated channel, subfamily H
- Inward rectifier potassium channel 2
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
- Potassium voltage-gated channel, KQT-like subfamily, member 1.2
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- FAU ubiquitin-like and ribosomal protein S30 fusion b
Sequence:
MTSPAHSTATEASWTAGAADLQMTEALHLRNDGVRFPSSVPVDPAVITQHPPSHLHPRMSVYSATRPTLSRSFLQGRVYNFLERPTGWKCFVYHFTVFLIVLSCLILSVLSTIDEYQALANKTLFWMELVLVMFFGVEYVVRLWSAGCRSKYVGILGRLRFARKPISVIDLIVVVASIIVLAFGSNGQVFATSAVRGVRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVDDHGNSGFGSYADALWWGVVTVTTIGYGDKVPQTWIGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQASWRCFALLNPDSATYKLFVKRNLSSSGSSPKLKVKMRRKMKISDRNNGQNSPAVPSITYDSFDDGRDSRQETLTSLQQSVISDGTNTTRRYERAPSWNSLSSFQFSTPPATKPGVFEVSSRPTLQRSSSIADDMETEPEREIVLIPVAHVSQLRDSHRAAIRVIQRMYYFVARKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDHSLGKQSLFQTSSERLKDKGTNTIGSRLNRMDEKITHMDRTLNSIAESLNLMLARERRGDLARGKEQRSTMRRQSATFSLSVLDSSEQLSTTTAIHEDS
Protein: Actin interacting protein 3-like C-terminal domain-containing protein (Q3V5J3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFGCIAPPRQSRSIIRSCSQDSREFHGDPRFQRPASVDLRQPRHPLTTRGRSATPPATLHGHPSQNNKPPKMKRLDKWIGNLLSERGSSGRIPPEENVGSDWRYADDVKVRIDPVDHQRPIDSQPSRFGQHPSRATSVLQNLREQKSNLEYDERRREVSTLPSSYSSNRPDIYGNVQRFDTVSRTESHLSSDSQATRHLDDMNVVFLQANDEVKRILLPRNIHSMHQVKMSFVRTFPNVNRSFVEQPHVKIYIQEPTKGAIFYELEDPGDIKNKSVLRLREKTRVMSPVGGGYLDQPDYHSETEQDDGRRVGMMPMMRPASAMAAPSVDYMHRNTLPLKPQPPPPQVYDIYSDPYNSDTSSHDSRSVTRSGSATPVIDRESRVRMETMERQLAGLSNLVHTALVSKGMSETTQKDMAELRREILSMHPDTARESSEKPASSLSDSISSHTAYQLSVFRSKLKDTHNELKQLKNSAQVNAQTGNTLLREAGDKIGRLVADRMRGGVSVMPIEIPATEMSNESQRNEHASQLAELLHSLTSFETNVETVRGSVLANQKKLRMSEVEDMTEKLTNIGRLAANLKTDFPPIQMAIEQQIKRDMERVVREEKFIRDQSIAVDQSLRRCKALANIMVTMKKLAMVQDPSIQRRKKHVERADSAGAPGSPRLPPKPSVAQTIAMHSAPPSPLTAPIPPPPPPPPPMLPPQQSQLAQSLQLAATSSNVVKVAPMYEYKESPKSPVSDLDNVLEEVGDPGSIPRPPSRYSVQDVRQKFSKPPELPDQLRNLIEDVARRASPGPEQMNDRRQDLEERQERLAEKQRQLRSQFQQLQQLAPLP
Protein: Nicotinamide adenine dinucleotide transporter 2, mitochondrial (AtNDT2) (NAD(+) transporter 2) (Q8RWA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the NAD(+) import into chloroplast. Favors the NAD(+)(in)/ADP or AMP(out) antiport exchange, but is also able to catalyze a low unidirectional transport (uniport) of NAD(+). Transports NAD(+), nicotinic acid adenine dinucleotide, nicotinamide mononucleotide, nicotinic acid mononucleotide, FAD, FMN, TTP, TDP, TMP, UTP, UDP, UMP, CTP, CDP, CMP, GTP, GDP, GMP, 3'-AMP, ATP, ADP and AMP, has low transport activity with cAMP, NADH and alpha-NAD(+), and has no activity with NADP(+), NADPH, nicotinamide, nicotinic acid, adenosine, thiamine mono- or diphosphate, inorganic phosphate, CoA, folate, NaCl, malate, malonate, citrate, fumarate, aspartate, glutamate, S-adenosylmethionine, lysine, arginine, and ornithine.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- NAD kinase 2, chloroplastic
- Nicotinate phosphoribosyltransferase 1
- Nicotinate phosphoribosyltransferase 2
- Probable inactive nicotinamidase At3g16190
- Nicotinamidase 1
- Nicotinamidase 3
- Mitochondrial pyruvate carrier 4
- COBRA-like protein 11
- Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic
Sequence:
MIEHGNSTFDYRSIREVAANAGAGATAGAIAATFVCPLDVIKTRLQVLGLPEAPASGQRGGVIITSLKNIIKEEGYRGMYRGLSPTIIALLPNWAVYFSVYGKLKDVLQSSDGKLSIGSNMIAAAGAGAATSIATNPLWVVKTRLMTQGIRPGVVPYKSVMSAFSRICHEEGVRGLYSGILPSLAGVSHVAIQFPAYEKIKQYMAKMDNTSVENLSPGNVAIASSIAKVIASILTYPHEVIRAKLQEQGQIRNAETKYSGVIDCITKVFRSEGIPGLYRGCATNLLRTTPSAVITFTTYEMMLRFFRQVVPPETNRSDDRRREEERKNLVSRRGEEEDKDLGLRESQTQSNKISTPHIPLGSK
Protein: Ribosomal protein L7/L12, putative (Q584I9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S14
- 60S ribosomal protein L17, putative
- Large ribosomal subunit protein uL5
- 50S ribosomal protein L17, putative
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L35, putative
- 40S ribosomal protein S13, putative
- 60S ribosomal protein L5, putative
Sequence:
MPLRESAETVEAIADAYVNMDLQTMRKFHDLVSNSMPWPPGTAPVSCEEMMLQGLAPGTCGGGRVVGATPTVPDAADGSAGNGSTADATVVKKVVEKATVDVSLKGYPAGSKVKLIKELRAVTGLALQEAKAAVERCPGMVATALPRGDAEKLKVLLEGHGAEVELL
Protein: FI07231p (GEO12704p1) (Troponin C) (Troponin C isoform 4, isoform A) (Troponin C isoform 4, isoform B) (Q7K860)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Troponin I
- Flightin
- Actin, indirect flight muscle
- Troponin C, isoform 1
- Stretchin-Mlck, isoform U
- Actin, larval muscle
- Myosin regulatory light chain 2
Sequence:
MADGEYDKEQLRILRNAFKAFDHDGAGSIEHADVSSILEILGQKLEPPAVKALIKEVDKGTTGKLDFSQFCKLAARFIEVEEDVGALQNELKEAFRVYDKEGKGYLTVATLRGILHELDDKLSNQDLDMIIEEIDADGSGTVDFDEFMQVMTG
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) (O75438)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- Acyl carrier protein, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
Sequence:
MVNLLQIVRDHWVHVLVPMGFVIGCYLDRKSDERLTAFRNKSMLFKRELQPSEEVTWK
Protein: Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) (Q8K3Y7)
Organism: Rattus norvegicus (Rat)
Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- TNF receptor superfamily member 25
- Tumor necrosis factor receptor superfamily, member 14
- Lymphotoxin B receptor)
- Tumor necrosis factor ligand superfamily member 8
Sequence:
MAEELGLGFGEAVPVEMLPEGCRHRREARTGLAARSKACLALTCCLLSFPILAGLSTLLMTGQLRIPGKDCMFPTVTEERSAPSAQPVYTPSRDKPKAHLTIMRQTPVPHLKNELAALHWENNLGMAFTKNRMNYTNKFLVIPESGDYFIYSQITFRGTTSECGDISRVRRPKKPDSITVVITKVADSYPEPAHLLTGTKSVCEISSNWFQPIYLGAMFSLEEGDRLMVNVSDISLVDYTKEDKTFFGAFLI
Protein: Bifunctional pinoresinol-lariciresinol reductase (PLR-La1) ((+)-lariciresinol reductase) (EC 1.23.1.2) ((+)-pinoresinol reductase) (EC 1.23.1.1) (Q4R0I0)
Organism: Linum album (Flax)
Function: Reductase involved in lignan biosynthesis. Catalyzes the enantioselective conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol. Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
Interaction partners:
Sequence:
MGSLGKVNNEIPTKSSGGSKVLVIGGTGYLGKRLVKASLDSGHDTYVMHRPEIGVDIEKVQLLLSFKMQGAHLVSASFDDQRSLVDAVKLVDVVICAISGVHIRSHQILLQLKLVEAIKEAGNVKRFVPSEFGTDPARMENAMEPGRITFDDKMVVRRAIEEAGIPFTYVSANCFAGYFLGGLCQPGYILPSRDHVTLLGDGDKKGVYVDEDDTAAYTLRAIDDPRTLNKTIYVKPPKNVLSQREVVGIWEKYIGKELQKTILSEQDFLATMREQNYAEQVGLTHYYHVCYEGCLSNFEVDDEQEASKLYPDVHYTTVEEYLKRYV
Protein: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase (NMN/NaMN adenylyltransferase) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase) (NMN adenylyltransferase) (NMNAT) (Nicotinate-nucleotide adenylyltransferase) (NaMN adenylyltransferase) (NaMNAT) (Q9UT53)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable nicotinate phosphoribosyltransferase
- Putative glutamine-dependent NAD
- Nicotinamide riboside kinase
- NAD-dependent histone deacetylase sir2
- Uncharacterized protein C24B11.05
- NAD-dependent protein deacetylase hst4
- Uncharacterized kinase C3H5.11
- Uncharacterized kinase C24B10.02c
- NAD-dependent protein deacetylase hst2
- IMP-specific 5'-nucleotidase 1
Sequence:
MHTMNGDNFANSFPKNPLLSRNSSSSNVIQYSDEFSPDEDWLNEHAAKEHEERIRRPSVNRAWQKNSTSGGPSVSLEKREADVASLGEVMDLEEVPRGITRQARQLNEYIFPKHRFRNHLVDEGKIPLVLVACGSFSPITYLHLRMFEMATDTIQEQTNMELVAGYFSPVNDHYKKEGLAPAYHRVRMCELACERTSSWLMVDAWESLQPSYTCTARVLDHFDEEINQKRGGITLSDGTKRPCKIMLLAGGDLIASMGEPGVWSDKDLHHILGKFGCCIVERTGSDVWAFLLAHDIMFAYRGNILVIKQLIYNDISSTKVRLFIRRGMSIRYLLPNSVIQYIERYALYRDAEPVKTIFYQSPFVRMEP
Protein: NEDD4-binding protein 3 (N4BP3) (Q8C7U1)
Organism: Mus musculus (Mouse)
Function: Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By similarity). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity).
Subcellular location: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, axon {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3LUD3}. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites. {ECO:0000250|UniProtKB:Q3LUD3}.
Interaction partners:
- Glucose-induced degradation protein 8 homolog
- WD repeat-containing protein 26
- Olfactory receptor
Sequence:
MATTSGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQREFFSYLHLPKKDGKTTKRAPRNEPDYATLYYREHPRAGDFSKTSLPERGRFDKCRIRPSVFKPPVGSGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRASQARAQLLHALSLDEGGPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHINHLGGSLDRAPRSPKESGPLAVLSCLPEPPPPYEFSCPTTEEVAVLPEAREELKRDLGDQDVSNSFTQVLEERQRLWLSELKRLYVERLHEVAQKAERSERNLQLQLFMAQQEQRRLRKELRAQQGLAPEPRTSGSSMEADPNARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVHSLQEQAPREEAPGSCETDDCKSRGLLGEAGGSEAREGAEQLRAELLQERLRGQEQALRFEQERQTWQEEKERVLRYQREIQGSYMDMYRRNQALEHELRLLREPPTSWSPRLESSKI
Protein: Hes-related family bHLH transcription factor with YRPW motif 2 (G3V7S6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Hes-related family bHLH transcription factor with YRPW motif-like
- Neurogenic locus notch homolog protein 1
- Protein jagged-1
- Delta-like protein 4
- Hairy/enhancer-of-split related with YRPW motif 1.
- Notch homolog 4, isoform CRA_b.
- Neurogenic locus notch homolog protein 2
- Recombining binding protein suppressor of hairless
Sequence:
MKRPCEETTSESDLDETIDVGSENNYSGHSASSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMSHHHHPLHPHHWAAAFHHLPTSLLQPNGLHTSESTPCRLSTSSEVPPAHGSALLTATFAHADSALRMPSTGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSSGTNSKPYRPWGTEVGAF
Protein: ABC transporter C family member 7 (ABC transporter ABCC.7) (AtABCC7) (EC 7.6.2.2) (ATP-energized glutathione S-conjugate pump 7) (Glutathione S-conjugate-transporting ATPase 7) (Multidrug resistance-associated protein 7) (Q9LK62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pump for glutathione S-conjugates.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter A family member 4
- ABC transporter A family member 5
- ABC transporter A family member 7
- ABC transporter G family member 35
- ABC transporter A family member 6
- ABC transporter A family member 3
- ABC transporter A family member 2
- ABC transporter A family member 8
Sequence:
MKQSYAMDNPIVFFLLESNYFPMFSIFFNLLLLLVMFGSCVYKKRLGWENSDAFTNERFKDMSLTYNKLVVICCETLSALNSVLLLLSCFNLHKNGWDRSELMILLDLLFTALSWGAISFYIRSQFTYSHDQKFPILLRVWWVLYFMFSCYRLLVDIALYKKQELVSVHLLLSDVLAVSVGLFLCYSCLQKQGQGERINLLLEEPLLNGAESSAATSVQLDKAEDDEVVTPFSNAGFLSHVSFSWMSPLIVLGNEKIIDSEDVPQVDNSDRAEKLFWIFRSKLEWDDGERRITTYKLIKALFFSVWRDILLSTLFAFVYTVSCYVAPYLMDTFVQYLNGQRQYSNQGVVLVTTFFVAKLVECQARRNWYFRLQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEIINLMTVDAERISAFSWYMHDPWILVLQISLALLILYRSLGLGSIAAFAATFLVMLGNIPLAKLEEKFQGNLMESKDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIEAGWLKKFVYNSAAISSVLWAAPSFVSATAFGACMLLKIPLESGKIIAALATFRILQTPIYKLPDTISMIVQTKVSLDRIATFLCLDDLQQDGMERLPSGSSKMDVEVSNGAFSWDDSSPIPTLKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGKVEENILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTVIYVTHQLEFLPEADLILVMKDGRITQAGKYNEILESGTDFMELVGAHTDALAAVDSYEKGSASAQSTTSKESKVSNDEEKQEEDLPSPKGQLVQEEEREKGKVGFTVYQKYMKLAYGGALVPIILVVQILFQVLNIGSNYWMAWVTPVSKDVKPLVSGSTLILVYVFLATASSFCILVRAMLSAMTGFKIATELFNQMHFRIFRASMSFFDATPIGRILNRASTDQSAVDLRLPSQFSNLAIAAVNILGIIGVMGQVAWQVLIVFIPVIAACTWYRQYYISAARELARLSGISRSPLVQHFSETLSGITTIRSFDQEPRFRTDIMRLNDCYSRLRFHAISAMEWLCFRLDLLSTVAFALSLVILVSVPEGVINPSFAGLAVTYALNLNSLQATLIWTLCDLENKMISVERMLQYIDIPSEPSLVIESTRPEKSWPCRGEITICNLQVRYGPHLPMVLRGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGINILTIGLHDLRSRLSIIPQEPTMFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKVLILDEATASVDTATDTLIQETLRQHFSGCTVITIAHRISSVIDSDMVLLLDQGLIEEHDSPARLLEDKSSSFSKLVAEYTASSDSRFKRSSMKTN
Protein: Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) (Q54BQ3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: This protein binds to a specific region on the 26S rRNA.
Interaction partners:
- Small ribosomal subunit protein eS8
- Protein transport protein Sec61 subunit alpha
- Large ribosomal subunit protein uL11
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL43
Sequence:
MAGKKVKSNTPKQDLSVSKSKLTSIKAPAAAIKAKAAASAVKKGVSNKSTRKVRTSVIFRRPVTLNNPKKPAYPRRSVNKITKMDQFRILKAPLTTESATQKIEGSNTITFMVDMFANKSQVADAVAKMYDVKVKRVNTLITPRGEKKAFVTLSPEFEAADVANKIGLI