wanglab/gogpt-training-data huggingface dataset:
Protein: AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Q9JME5)
Organism: Mus musculus (Mouse)
Function: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Interaction partners:
- AP-3 complex subunit delta-1
- AP-3 complex subunit mu-2
- AP-3 complex subunit mu-1
- AP-3 complex subunit sigma-2
- AP-3 complex subunit sigma-1
- AP-3 complex subunit beta-1
- AP-4 complex subunit epsilon-1
- AP-1 complex subunit gamma-1
- AP-1 complex subunit gamma-like 2
- AP-2 complex subunit alpha-1
Sequence:
MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENPEKAFYGSEEDEAKGPGSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPKIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKPAPILESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSEPESESESESKSSSGSGSGESSSESDNEEEDEEKGGGSESEQSEEEDEKKKKTKKKKASEGHREGSSSEEGSDSSSSSESEVTSESEEEQVEPASWRKKTPPGSKSAPVAKEISLLDLEDFTPPSVQPVSPPMVVSTSLAADLEGLTLTDSSLVPSLLSPVSSIGRQELLHRVAGEGLSVDYAFSRQPFSGDPHMVSLHIYFSNNSETPIKGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQAANFQLCTQTRQFYVSIQPPVGELMAPVFMSENEFKKEQGKLTGMNEITEKLTLPDTCRSDHMVVQKVTATANLGRVPCGTSDEYRFAGRTLTSGSLVLLTLDARAAGAAQLTVNSEKMVIGTMLVKDVIQALTQ
Protein: Neurogenic locus protein delta (P10041)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Neurogenic locus Notch protein
- Protein neuralized
- E3 ubiquitin-protein ligase mind-bomb
- Echinoid, isoform A
Sequence:
MHWIKCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCEHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECLMYGGYVASVADNNNANSDFCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSAKGASGGGPGAAEGKRISVLGEGSYCSQRWPSLAAAGVAGACSSQLMAAASVAGSGAGTAQQQRSVVCGTPHM
Protein: Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) (A0A0R4IQG1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase.
- Farnesyl pyrophosphate synthase
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase 2
- Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
- Squalene synthase
- 3-hydroxy-3-methylglutaryl-CoA lyase.
- Acetyl-CoA acyltransferase 2
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
Sequence:
MPGSLPAICESMWPKDVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDQCYSVYKNKIHARWQREGTEGRCSLEDFGFMVFHSPYCKLVQKSLARLMLNDFLCHPSPNMESGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASSELFDDKTKASLLISNQNGNMYTPSVYGCLASVLAQHTPQQLAGQRIGVFSYGSGFAATLYSIKVTQDGTPGSALDKLVSSLCDLPARLDSRQKVSPGVFAETMKLREETHHLANYIPQGSVDELFPGTWYLTRVDEKHRRQYARRSMNDDRPLEAGLVSSSMAAEHIPSPLKKMPRIPTTTAGPEVVVMSNGDH
Protein: Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 7 (Q2YDQ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASYSPTPAEEASPEVSNGNLKASSSQESMKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSGSYGLSLVVWTIGGIFSVFGALCYAELGTTITKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFSNYMVQPIFPTCIAPYVANRLLAAACICLLTFVNCAYVKYGTRVQDFFTYVKVVALIAVIITGLVKIFQGYTQNFEGLFSDSSHDPGDVALALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIAISMPIVTVIYILTNLAYYTILPIPAILDSDAVAVTFADQVFGYLNWTIPVAVAFSCFGGLNASIVAASRLFFVGSREGHLPDYLCMIHITRFTPIPALLFNGAMALVYLCVEDVFKLINYYSFSYWFFVGLSILGQLYLRWKQPDRPRPLKLSLFFPIIFCLCTVFLVVVPLYSDTINSLIGIGIALPGVPVYFLCCHLPATRRPMWLRKFIASSGVLIQKVCFCVLTEMDKEEEKTE
Protein: Histone H3 (C1BEZ2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Histone H4
- Retinoblastoma-binding protein 5
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Alpha-1,2-mannosyltransferase 1 (EC 2.4.1.-) (Q4WV44)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18708564}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSSGPKYMRYLLFAAVGLAVFFLISRSSIPIPENIGSKLSPANYKDTISQSDKAHNDAPPKPPVKETPGSANTAPVGRVNATFVTLARNSDVWDIAKSIRQVEDRFNRNYHYDWVFLNDKPFDDTFKKVTTSLVSGKTFYGEIPKEHWSYPDWIDQEKAKKVREEMGQKKIIYGDSESYRHMCRYESGFFFRHPLMLNYEYYWRVEPSIELYCDISFDPFKLMKEQNKKYSFVLSLYEYYDTIPSLWDSVKKFMGNHPEHIAEGNAMGFLSDDGGKTYNKCHFWSNFEIGSLEWLRSKQYLDYFDALDHDGGFFYERWGDAPVHSIAAGIMLKKEEIHFFNEIAYYHIPFTHCPTSEQMRLDLKCHCNPSENFDWKGYSCTSRWFQINDMEKPEGAEEQS
Protein: Cyclic AMP response element-binding protein A (cAMP response element-binding protein A) (dCREB-A) (Box B-binding factor 2) (BBF-2) (P29747)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'.
Subcellular location: Nucleus.
Interaction partners:
- Cyclic AMP response element-binding protein B
Sequence:
MEFYDGDLKDIWDSDLDPESLKISPDHDMHDWLFDRDVKDPTVILNDKLISDALLNGTQPIKTEHSYSLSSDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHATPISRLSSNPALNTSVADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPIHTPLISSQPKGSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALVSKHNVKKS
Protein: Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1) (B8ZXI1)
Organism: Mus musculus (Mouse)
Function: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:19414587}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:19414587}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:19414587}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:19414587}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:19414587}.
Interaction partners:
- Queuine tRNA-ribosyltransferase catalytic subunit 1
- 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial
- Threonylcarbamoyl-AMP synthase
Sequence:
MKLSLIKVVNGCRLGKIQNLGKAGDCTVDIPGCLLYTRTGSAPHLTHQTLRNIHGVPGIAQLTLSSLAEHHEVLAEYKKGVGSFIGMPESLFYCSLHDPVTPGPAGYVTSKSVSVWGFGGRVEMTVSKFMAIQEALQPDWFQCLSDGEASCAETTSIKRARKSVDRSLLFLDSCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGDPAVTETRLHLLSSVTAELPEDKPRLICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFTFDCQLNPEETLLQQNGIQEKIKGLDQAKKIEATGCNQEMTSFEINLKEKKYQEDFDPLVRGCSCYCCKNHTRAYIHHLLMTNELLAGVLLMMHNFEHYFGFFCSIREALKNDTLAQLKELICRQMF
Protein: AAA-ATPase At3g28600 (EC 3.6.1.-) (F4J0C0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ulp1 protease family protein
- Jacalin-related lectin 33
- Secreted transmembrane peptide 6
- Geranylgeranyl pyrophosphate synthase 11, chloroplastic
- AT5g19120/T24G5_20
- DnaJ domain protein
- At2g17880
- Glycine--tRNA ligase, chloroplastic/mitochondrial 2
Sequence:
MMMGNTFGSSLASLFFLWATIQQIFPNHLRIAIKEFLISTIQQLSFVQRFSDRFINFFSPYVEISFSQYEDYQFNHAFAAIETYLGAKATDKAKHLRASQVKESKGLVLKRDETKVRDEYEGGTVWWEMETDSTGYRTFKLTFHRRSRDIVTDSYIKYVFEEGKSIQAKSKQMKLFTNNPSSHWGTSKKSFWRYIDFEHPASFHTLAMDTKKKEEILNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNNSELRKLLTATSSKSIIVIEDIDCSLDLTGKRKKEKNLMTSREDGEQGTEEDKSFVTLSGLLNFIDGIWSACGQERIIIFTTNHFEKLDPALIRRGRMDMHIELSYCSFEAFKILAKNYLDLDTHPLFKKIESLLKETKIAPADVAENLMKKNTEIDADGSLKDLIQALEGKKKIHGAQVDEPKDKYTKKFYKAFCMSSKA
Protein: Prohibitin-6, mitochondrial (Atphb6) (Q9SIL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:12837548, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17883375, ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:21841088}; Single-pass type II membrane protein {ECO:0000269|PubMed:12837548, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17883375, ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:21841088}.
Interaction partners:
- Prohibitin-3, mitochondrial
- Prohibitin-4, mitochondrial
- Prohibitin-5, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8-A
- ATP synthase subunit beta-2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8-A, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8-B
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
Sequence:
MNFKNVKVPKGPGGGVIAAVVIGGLSLYGATHTLYNVDGGHRAIVFNRLVGIKDKVYPEGTHLMIPWFERPIIYDVRAKPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEVYRSLGENYRERVLPSIIHETLKAVVAQYNASQLITQRESVSREIRKILTLRAANFHIALDDVSITGLTFGKEFTAAIEGKQVAAQEAERAKFIVEKAEQDKRSAVIRAEGEAKSAQLIGQAIANNQAFLTLRKIEAAREIAQTISRSANKVYLSSNDLLLNLQAMDLDVKPKK
Protein: Probable endo-1,4-beta-xylanase B (Xylanase B) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase B) (Endo-1,4-beta-xylanase G1) (Xylanase G1) (A2Q7I0)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MLTKNLLLCFAAAKAALAVPHDSVAQRSDALHMLSERSTPSSTGENNGFYYSFWTDGGGDVTYTNGDAGAYTVEWSNVGNFVGGKGWNPGSAQDITYSGTFTPSGNGYLSVYGWTTDPLIEYYIVESYGDYNPGSGGTYKGTVTSDGSVYDIYTATRTNAASIQGTATFTQYWSVRQNKRVGGTVTTSNHFNAWAKLGMNLGTHNYQIVATEGYQSSGSSSITVQ
Protein: Apelin receptor A (Angiotensin receptor-like 1a) (xAngio1) (Angiotensin receptor-related protein A) (G-protein coupled receptor APJ-A) (APJa) (Mesenchyme-associated serpentine receptor) (x-MSR) (P79960)
Organism: Xenopus laevis (African clawed frog)
Function: Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (By similarity). Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure (By similarity). Acts upstream of the i/o type of G-alpha proteins in the differentiation of endothelium, erythroid cells, myeloid cells and cardiomyocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17412318}; Multi-pass membrane protein {ECO:0000269|PubMed:17412318}. Note=Internalized to the cytoplasm after exposure to apelin (apln) (PubMed:17412318). After exposure to apelin receptor early endogenous ligand (apela), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P35414, ECO:0000269|PubMed:17412318}.
Interaction partners:
Sequence:
METEGLSPMLYEDDYYYGNETGLQPCDETDWDFSYSLLPVFYMIVFVLGLSGNGVVIFTVWKSKPKRRSADTYIGNLALADLAFVVTLPLWATYTALGFHWPFGSALCKLSSYLVLLNMFASVFCLTCLSFDRYLAIVHSLSSAKLRSRSSIIVSLAVIWLFSGLLALPSLILRDTRVEGNNTICDLDFSGVSSKENENFWIGGLSILTTVPGFLLPLLLMTIFYCFIGGKVTMHFQNLKKEEQKKKRLLKIIITLVVVFAICWLPFHILKTIHFLDLMGFLELSCSTQNIIVSLHPYATCLAYVNSCLNPFLYAFFDLRFRSQCFFFFGFKKVLQGHLSNTSSSLSAQTQKSEIHSLATKV
Protein: Protein TIFY 4A (Protein PEAPOD 1) (Q7XA73)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the arrest of dispersed meristematic cells during lamina development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Fanconi anemia group I-like protein
- AT5G65740 protein
- GATA transcription factor 28
- Fanconi-associated nuclease 1 homolog
- GATA transcription factor 25
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- Ubiquitin-ribosomal protein eS31y fusion protein
- Large ribosomal subunit protein uL1c
- Uncharacterized protein At3g24150
Sequence:
MDVGVSPAKSILAKPLKLLTEEDISQLTREDCRKFLKDKGMRRPSWNKSQAIQQVLSLKALYEPGDDSGAGIFRKILVSQPVNPPRVTTTLIEPSNELEACGRVSYPEDNGACHRMDSPRSAEFSGGSGHFVSEKDGHKTTISPRSPAETSELVGQMTIFYSGKVNVYDGIPPEKARSIMHFAANPIDLPENGIFASSRMISKLISKEKMMELPQKGLEKANSSRDSGMEGQANRKVSLQRYREKRKDRKFSKAKKCPGVASSSLEMFLNCQPRMKAAYSQNLGCTGSPLHSQSPESQTKSPNLSVDLNSEGI
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 6 (Protein BRAWNIN) (Q8BTC1)
Organism: Mus musculus (Mouse)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand. Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:32161263}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q69YU5}.
Interaction partners:
Sequence:
MPGGVPWSAYLKMLSSSLLAMCAGAQVVHWYYRPDLTIPEIPPKPGELKTELLGLKERRHEPHVSQQ
Protein: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic (EC 1.17.7.1) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein CHLOROPLAST BIOGENESIS 4) (Protein CONSTITUTIVE SUBTILISIN 3) (F4K0E8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Is essential for chloroplast development and required for the salicylic acid (SA)-mediated disease resistance to biotrophic pathogens.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:11943178, ECO:0000305|PubMed:18236010}.
Interaction partners:
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase
- Hydroxymethylglutaryl-CoA synthase
- 1-deoxy-D-xylulose-5-phosphate synthase
- Phosphomevalonate kinase, peroxisomal
Sequence:
MATGVLPAPVSGIKIPDSKVGFGKSMNLVRICDVRSLRSARRRVSVIRNSNQGSDLAELQPASEGSPLLVPRQKYCESLHKTVRRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLVQLNYNIPLVADIHFAPTVALRVAECFDKIRVNPGNFADRRAQFETIDYTEDEYQKELQHIEQVFTPLVEKCKKYGRAMRIGTNHGSLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMYVHGWDYPLHLGVTEAGEGEDGRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGTKAAKLQQGVAPFEEKHRHYFDFQRRTGDLPVQKEGEEVDYRNVLHRDGSVLMSISLDQLKAPELLYRSLATKLVVGMPFKDLATVDSILLRELPPVDDQVARLALKRLIDVSMGVIAPLSEQLTKPLPNAMVLVNLKELSGGAYKLLPEGTRLVVSLRGDEPYEELEILKNIDATMILHDVPFTEDKVSRVHAARRLFEFLSENSVNFPVIHHINFPTGIHRDELVIHAGTYAGGLLVDGLGDGVMLEAPDQDFDFLRNTSFNLLQGCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTVVKRGIAMTEATDALIGLIKEHGRWVDPPVADE
Protein: RING-H2 finger protein ATL80 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ATL80) (Q9LM69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the early steps of the plant defense signaling pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-1,3/1,6-mannosyltransferase ALG2
- Pectin lyase-like superfamily protein
- Alpha/beta-Hydrolases superfamily protein
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- Cysteine-rich repeat secretory protein 59
- non-specific serine/threonine protein kinase
- Probable protein phosphatase 2C 61
- At1g04210
Sequence:
MARLLFRLLVESNTPSPAIDNSTAALNSDLVVILAALLCALICVLGLIAVSRCVWLRRLAAGNRTVSGSQTQSPQPPVAAANKGLKKKVLQSLPKLTFSPESPESEKFAECAICLAEFSAGDELRVLPQCGHGFHVACIDTWLGSHSSCPSCRQILVVARCHKCGGLPGSSSSGLESEPEIEIRIKQGEDDPNSFLP
Protein: Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) (P11798)
Organism: Mus musculus (Mouse)
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (By similarity). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (By similarity). Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity.
Subcellular location: [Isoform Alpha KAP]: Cytoplasm {ECO:0000305|PubMed:8524307}.; SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:28642476}. Postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9UQM7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9UQM7}. Note=Postsynaptic lipid rafts. {ECO:0000250|UniProtKB:P11275}.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor 1
- Calmodulin-1
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- Calmodulin-like protein 4
- Calmodulin 5
- Calmodulin-4
- Calmodulin-like protein 3
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Glutamate receptor ionotropic, NMDA 1
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH