wanglab/gogpt-training-data huggingface dataset:
Protein: Leucine-rich repeat-containing protein (Q54B43)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
- Formin-G
Sequence:
MSSELSTGEKRFVFDLEGCDPDFILWVKKTNKKDVVQDRLFVLTKYRIYSIKRNKVGGKKQVQRESHLYNLVEIRTDDIDRVVLKFTTFSIDMTGGNIGITIPKLLINAFHRISFTFSNEALPNLLILPPERTAPEVDEIDPGQSHGFFEVYRAQCNYYDTPVNQDLIDYLEETVSKGSRVFNLDDFAGIDRNSEGAVNLTPVLAALRHNTFFDTFVCHNKTRKEIPLLLADVFHHNRTLVRVDLSGIESDDGWVQLGDALKENQTNQLVSLNCSDNRVSDKGMNSLANAIRSFNRPFLEFIASNVDLQSKGASIFFRTLQSNYSSSGAIVHLDVSRNDLEKIGSESLHDWIILLNTSIPSPRKPLVHINLEETQLDTTKVTMALKQGQLESLEYINLSGNKFTPEAVANLCSIIAKCDSLAQIKLSKCSITGDQVNNILNACTSGIQVHDRTLDLSSNNLEQKGALSFAQTIKSSSNIAHLNLANNSFRKKGITFIVQALEENSTLQSIDLSSNFKSSSKAEPIVDHIARTVHHHVSIRKLVLAGSVSKGFYLGKELLPLVKSLVNDCKLVELDISGNNMGDDICRELFESLKKNTCLKTLHLDNNSLGLAGFQAMKRTFTTNRTLIDIPVPTADITKILNSNSKDKKQINDKIGEILADVQTCLSNNKNGIAYTDIPSTTKTTVAISSISTPNFRASTYHNSSSNNLGNSDDTYNRAASTHNLSYSSPSPSTYAPPPPLPDVYANHYQQPPPPPPQETYDYSQQHQQYDYSQQQQQQQQQYDYSQQHTDQQQYDYQAQDYQEGATTNDYDQQYQQQDYSQQQQYDDQQQQQQQYDDQQQHYDDQQQYEDENRMPPPPEY
Protein: Zinc finger protein 148 (Beta enolase repressor factor 1) (G-rich box-binding protein) (Transcription factor BFCOL1) (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) (Q61624)
Organism: Mus musculus (Mouse)
Function: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSAVSGELQESVLQDRSLPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMDTHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQVREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESVLDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQSQTISPLSSYEDSKVSKYAFELVDKQALLDSEGSADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILDSQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKPNGQHEISFSVADTEVTSSISINSSDVPEVTQSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNPPAFSSIDKQVYAAMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHPFPFSGDETNHASATSTADFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAGMTSSPDATTGQTFG
Protein: Calreticulin-3 (Calreticulin-2) (Calsperin) (Q96L12)
Organism: Homo sapiens (Human)
Function: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:21590275}.
Interaction partners:
- Endoplasmin
- Endoplasmic reticulum chaperone BiP
- Protein disulfide-isomerase A6
- Protein disulfide-isomerase A3
- Protein disulfide-isomerase-like protein of the testis
- Hypoxia up-regulated protein 1
- Calnexin
Sequence:
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL
Protein: Probable WRKY transcription factor 41 (WRKY DNA-binding protein 41) (Q8H0Y8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable WRKY transcription factor 51
Sequence:
MEMMNWERRSLLNELIHGLKAAKQLQGSSSPSLSASSSYLTTEIKENLLHNIVSSFKKAILMLNGSTTQHNPTIELAPDPLAHPGKVPGSPASITGNPRSEEFFNVRSKEFNLSSKKRKMLPKWTEQVRISPERGLEGPHDDIFSWRKYGQKDILGAKFPRSYYRCTFRNTQYCWATKQVQRSDGDPTIFEVTYRGTHTCSQGIPLPEKRETKPKHTVAVNYQNLRASLTVRTGGLGSEAFSFPVTSPLYTYESINGGGTFYHHVGSSGPSDFTGLISTNTSTGSSPIFDVNFQFDPTAEINTGFPTFFHNSI
Protein: Cytochrome c oxidase assembly protein COX19 (Q3E731)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the assembly of mitochondrial cytochrome c oxidase.
Subcellular location: Cytoplasm. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Mitochondrial intermembrane space import and assembly protein 40
- Cytochrome c oxidase copper chaperone
- COX assembly mitochondrial protein
- Cytochrome c oxidase assembly protein COX11
- Cytochrome c oxidase-assembly factor COX23
- Mitochondrial intermembrane space cysteine motif-containing protein MIX17C motif protein of 17 kDa)
- Mitochondrial intermembrane space cysteine motif-containing protein MIX14C motif protein of 14 kDa)
- Mitochondrial FAD-linked sulfhydryl oxidase ERV1
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial protein PET191
Sequence:
MSGNPGSSLSALRPTPPERGSFPLDHDGECTKYMQEYLKCMQLVQNENAMNCRLLAKDYLRCRMDHQLMDYDEWSHLGLPEDAPGNNGKTIKDATDNK
Protein: Delta-1 crystallin (Delta crystallin I) (P24057)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Function: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase.
Interaction partners:
Sequence:
MASEGDKLMGGRFVGSTDPIMQMLSTSISTEQRLSEVDIQASIAYAKALEKAGILTKTELEKILSGLEKISEELSKGVIVVTQSDEDIQTANERRLKELIGDIAGKLHTGRSRNEQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAGNPLDIDREMLRSELEFASISLNSMDAISERDFVVEFLSVATLLLIHLSKMAEDLIIYSTSEFGFLTLSDAFSTGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQEDKEAVIDVVDTLTAVLQVATGVISTLQISKENMEKALTPEMLATDLALYLVRKGMPFRQAHTASGKAVHLAETKGIAINNLTLEDLKSISPLFSSDVSQVFNFVNSVEQYTALGGTAKSSVTTQIEQLRELMKKQKEQA
Protein: Septin (Q9U277)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSDIEHKLQHLPPHQPPPPVPHHHQNQPTHNNTTTISSATSSINTTTTSKKPTIAAPTAPSPIKSLSDHTGRVMQLNGHVGFDSLPHQLVKKAVEAGFQFNLMCVGETGTGKTTLIESLFNMKLDFEPCNHELKTVELRTCTKDVAEGGIRVKLRLVETAGFGDQLDKDKSAKVIVDYLESQFETYLQEELKPRRMLQYFNDSRIHACLYFISPTGHGLKALDLVTLRELAKRVNVIPVIAKSDTTCKDELLRFKAKILSELKSQKIDIYTFPTDDETVSTTNKEMNKSVPFAVVGSIDFVKKENGQMVRARQYPWGIVEVENESHCDFVKLREALLRTNVDEMRQRTHESLYENYRRDRLRQMKIGDGETGPKIIEKLAQKHREHQDEFSRRELTLREEFQKKLDVTEGDMRKVEEGLAAREREVHENYNREASKLDMEIRQLTEERMKLMTKVSKKLRK
Protein: Immunoglobulin heavy variable 1-69 (Ig heavy chain V-I region EU) (Ig heavy chain V-I region SIE) (Ig heavy chain V-I region WOL) (P01742)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
Sequence:
MDWTWRFLFVVAAATGVQSQVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCAR
Protein: DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1) (Q8C7R7)
Organism: Mus musculus (Mouse)
Function: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:20148032}.
Interaction partners:
- Homeobox protein Nkx-6.1
- Motor neuron and pancreas homeobox protein 1
- Neurogenin-3
- Paired box protein Pax-4
- Neurogenic differentiation factor 1
- Homeobox protein Nkx-2.2
- Pancreas transcription factor 1 subunit alpha
Sequence:
MAKVRELEEAFVQEQPSPQLPSEIAEECCAQLLGKGLLVYPEDSAYLLAETAAGARSSGEKGGDPGLQVGVKSEMQLNNGNFSSEEEDADTQESKTKAADPQLSQKKSITQMMKDKKKQTQLTLQWLEDNYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSSLKRQTSFLHLAQIARPALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDTESDIYSEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKMSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKASSLASDTVKNESHVETSYVPLPSSQPGAIPPALHPFSTEDTDNMPLPGQIELSQSTGHLMTPPISPAIASRGSVINQGPMASRPPSVGTVLSAPTHCSTYAEPIYPTLSPANHDFYGTNSNYQTMFRTQSHPASSLYAHRAEHGRCMAWTEQQLSRDFFGGSCAGSPYNCRPPSSYGPSTHTQESHSMQVLNTGSFNFLSNAGAGSCQGSTLPSNSPNGYYGNNINYSEAHRLGSMVNQHVSVISSVRSLPPYSDIHDPLNILDDSSRKQNNSFYADTLSPVACRTTVVASNLQTQIPSSSSQCMYGTSNQYPVQDSLDSNAASNREMVSSLPPINTVFMGTAAGDT
Protein: Methylcrotonoyl-CoA carboxylase 1 isoform 1 (A0A0S2Z693)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDKRESE
Protein: SPbeta prophage-derived UPF0714 protein YoqZ (O31913)
Organism: Bacillus subtilis (strain 168)
Interaction partners:
- SPbeta prophage-derived uncharacterized protein YorA
- PGA biosynthesis protein CapC
- PGA synthase CapB
- SPbeta prophage-derived uncharacterized protein YorB
Sequence:
MLKFKNRIVEKRVKGAEKASFGGPVLLYRTLRKVTKLYKYITDKKSFPILVTSLFALFNPNSVLAADKYSNFEELKENESPLSYNILTTDVDRRVLILAPHGGGIEGGTSELARELSKSYSAYLFEGLRIPGASELHITSTNFDEPQALDLLSKHDLTISIHGYASSKKHTLVGGTDREKAAKITSLLTDAGFSAELLSEDSRLAGTNEQNIANKNSTGMSIQLEISTEQRREMFNTFTLAGRNGTQNQVFYDYIAVLTKFINENVYCMAGVAP
Protein: DNA-directed RNA polymerase subunit Rpo11 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit L) (P46217)
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00261}.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo1N
- DNA-directed RNA polymerase subunit Rpo3
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase subunit Rpo7
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo10
- DNA-directed RNA polymerase subunit Rpo2
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo4
Sequence:
MEIKVIKEEQNYLELQIDGEEHTIGNLLKGMLLKVPGVKFAAYSLPHPLITSITIKILTDGSISAREALIKAIELAENYANLFIDEVKKI
Protein: Monopolin complex subunit pcs1 (Chromosome segregation protein 1) (O13684)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S.cerevisiae ortholog CSM1, is not required ofr mono-orientation during meiosis I.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12689592}. Chromosome, centromere {ECO:0000269|PubMed:12689592}. Note=Nucleolar during G2 (PubMed:12689592). Localizes to the centromeres throughout most stages of vegetative growth and meiotic development apart from the horse tail stage of prophase I (PubMed:12689592). Localizes to the central core of the centromere (PubMed:17627824).
Interaction partners:
- Monopolin complex subunit mde4
- Kinetochore protein mis13
- Ubiquitin-like-specific protease 2
- Inner kinetochore subunit cnp3
- Kinetochore protein spc25
- Kinetochore protein spc24
- Inner kinetochore subunit fta1
- Monopolar attachment protein 1
Sequence:
MRKNNMQTSKDSELKEQAKGKSSKLIHKLPKQRTRISQGQMHSTQDFVNNEDQDAYSVRENENELHINNSGMSELNKKLQLPNVELSTLSHTQEQEFNELNKLIRKINELQEFYLLEDLAKPVTNAGADADDTIVKDLKKELENEKKANHSLKNELLKTREQIKNYSKINILIKELFGLEVADCIEDEDGYRFNCKNTGRRGTLEYQLLLDDQNFTFTPRLNVQTDEELMKHLPDYLLEEIIFTKEQGKLFSARLMKALQD
Protein: Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein) (Q7Z3S9)
Organism: Homo sapiens (Human)
Function: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:14673143, ECO:0000269|PubMed:29856954}. Cytoplasm {ECO:0000269|PubMed:14673143}.
Interaction partners:
Sequence:
MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
Protein: ADAM metallopeptidase with thrombospondin type 1 motif 9 (E9PUN6)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MQLVSWATLLTLLVPDLVEMRSPDSAAAVRKDRLHPRQVKLLESLSEYEIASPIRVNPLGEPFPTNVHFKRRRRSINSASDPWPAFASSSSSSTSSQEHYRLSAFGQQFLFNLTAHTGFIAPLFTVTLLGEPGVNQTKLYSEEEMELRHCFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYFIEPLQSVDEQEDEEEQNKPHIIYRHSTPQREPSTGKHACATSELKNSHSKDKRKIRMRKRRKRNSLADDVALLKSGLATKVLSGYSNQTNSTRDRWNHKRTKRFLSYPRFVEVMVVADHRMVLYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQHSKNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPASRTYPLPSQLPGLLYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVDGAHKGCRTQHTPWADGTECEPGKHCKFGFCVPKEMEGPAIDGSWGGWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCMKQKRDFREEQCAHFDGKHFNINGLLPSVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHILNSKARKDKCGICGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATSIDVRQHSFSGKSEDDNYLALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGSDNVVERLNCTDRIEEELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERRRKLVCTRESDQLTVSDQRCDRLPQPGPVTEACGTDCDLRWHVASKSECSAQCGLGYRTLDIHCAKYSRMDGKTEKVDDSFCSSQPRPSNQEKCSGECSTGGWRYSAWTECSRSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVVVQSCNEFSCPHWKTGDWSECLVTCGKGHKHRQVWCQFGEDRLSDRMCDPEAKPEPMQTCQQPECAAWQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASCHPSILALEPRRNAQSIPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEDGSVADESACATLPKPVAKEECSVTPCGQWKALDWSSCSVTCGQGKATRQVVCVNYSDHVIDRSECDPDYIPETDQDCSMSPCPQWTGLAHPFQNEDFRPRSDSPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGSWGECTKLCGGGMRTRLVVCQRANGDRFPDLSCEVLDKPTDREQCNTHACPQDAAWSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESDNCKHLPKPHGHRRCRGGRCPRWKAGAWSQCSVSCGQGVQQRHVGCQIGTHKAARESECSSYSRPESERVCQASPCPLYTWRAEQWQQCTKTCGEGSRYRQVVCVAEDQSEVHSTHCDSDQRPPDRESCSLQPCEYVWITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYSYQTTVNCPGAQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGIGVMHRSVQCLTNEDQPSHLCPTDTKPEERKACRNVYNCELPQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHCRKDYTAAGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVS
Protein: Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate terminal protein (iTP); Terminal protein (TP)] (P03269)
Organism: Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Function: Protein covalently bound to the viral DNA that acts as a primer for viral genomic replication by DNA strand displacement. Assembles on the viral origin of replication in an initiation complex with viral polymerase, DBP, host NFIA and host POU2F1/OCT1. During initiation, the polymerase covalently couples the first dCTP with Ser-580 of pTP. The terminal protein stimulates the template activity over 20 fold compared to protein-free templates. Neo-synthesized viral genomes are linked to two preterminal proteins, one for each 5' end. These new genomes are encapsidated in the nucleus, and during capsid maturation by viral protease, preterminal protein is first cleaved into intermediary (iTP), then into mature TP. May play a role in host nuclear matrix localization of genomic DNA.
Subcellular location: Host nucleus matrix {ECO:0000255|HAMAP-Rule:MF_04061}.
Interaction partners:
Sequence:
MALSVNDCARLTGQSVPTMEHFLPLRNIWNRVRDFPRASTTAAGITWMSRYIYGYHRLMLEDLAPGAPATLRWPLYRQPPPHFLVGYQYLVRTCNDYVFDSRAYSRLRYTELSQPGHQTVNWSVMANCTYTINTGAYHRFVDMDDFQSTLTQVQQAILAERVVADLALLQPMRGFGVTRMGGRGRHLRPNSAAAVAIDARDAGQEEGEEEVPVERLMQDYYKDLRRCQNEAWGMADRLRIQQAGPKDMVLLSTIRRLKTAYFNYIISSTSARNNPDRHPLPPATVLSLPCDCDWLDAFLERFSDPVDADSLRSLGGGVPTQQLLRCIVSAVSLPHGSPPPTHNRDMTGGVFQLRPRENGRAVTETMRRRRGEMIERFVDRLPVRRRRRRVPPPPPPPEEEEEGEALMEEEIEEEEAPVAFEREVRDTVAELIRLLEEELTVSARNSQFFNFAVDFYEAMERLEALGDINESTLRRWVMYFFVAEHTATTLNYLFQRLRNYAVFARHVELNLAQVVMRARDAEGGVVYSRVWNEGGLNAFSQLMARISNDLAATVERAGRGDLQEEEIEQFMAEIAYQDNSGDVQEILRQAAVNDTEIDSVELSFRFKLTGPVVFTQRRQIQEINRRVVAFASNLRAQHQLLPARGADVPLPPLPAGPEPPLPPGARPRHRF
Protein: Esculentin-1R (P86018)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:18855342}.
Interaction partners:
Sequence:
GIFSKLAGKKLKNLLISGLKSVGKEVGMDVVRTGIDIAGCKIKGEC
Protein: Protein DOP1 (Q03921)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16219684, ECO:0000269|PubMed:16301316}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16219684, ECO:0000269|PubMed:16301316}. Note=Late Golgi.
Interaction partners:
- Protein MON2
- Scramblase ANY1
- Phospholipid-transporting ATPase NEO1
- ADP-ribosylation factor-like protein 1
Sequence:
MSLPLKPLTIDSNNKQLDSKQKKFRANVERALERFDSVTEWADYIASLGTLLKALQSWSPKFQNVRYYVPSPYQVSRRLTSSLSPALPAGVHQKTLEVYTYIFEHIGLETLATECNIWIPGILPLMTYASMSVRSHLIELYDNYILLLPQTTLRLLIRPLISSLLPGIDDESNDFLPLTLKLIETLQENLDDDSLFWQTLFLVMTANKGRRLGGLTWLTRKFPSLNAVPHLVNKIKMEAEENPSETETNDSHLDRKKRKEEAFKVLLPAAKDLVTPEPGLLIRCLVGCLEDENDILIKRSVLDLLLQRLRLDSPVLNVLITSEDKKLLIMSCCRTTLSKDMSLNRRIWNWLLGPTAGGMLNNNGGNSMEYTTSVKSANEESNVYFTKYGLSALLEGLSDLLSEEESVLTAFRISMAVMDRWEIGSLVIPELFIPLLYSSEKFKQNEQIMKTARTFFDNTETNIIWGKLFQELEDIKNLKILDFVLTNFNIGNDEEIIVRHLPLILLTLLALPSNDKDFDNIYKLQKFSLYNKLLNYIPERALLPLSHSKLKHDDEVSCEELLAKIRGFYTNVSNPSSILEKENIAERLPPFTTEDLTFLIADLIQKKLLSSLWDLENINESSKLFIAIFEKIPESEELKGRSHISWSDKKITQSIFEAIPRLCESNNDAKSEEIVGIVEIFGNYLYSRMEFIESMKLLKVVMMAVWKSLKDPRHQILGVKNLKTLNRFIPSKFIESALVYTFVEEEDISERLSVLDLLWTQLDSDSNLIRRPLELILGELFDDQNPFYLTVSKWILSILNSGSASRLFYILTDNILKVNRLEKERLDERDDLDMLTYEFQMLAYVLKTNNGRTRKVFSTELTSIKSSTIWKNEDVSTYKSLLLVTLMRFLNIKSNTHAKSIRSALILLDILLDGTEQNFKDIVIFLLQMSSKYIAEEGIEPELIAVSLLDIVSKVLRLSHDNGIKLDIFDDNAAHLKYIDFLVTSVSNMKSPLIVTAYVKLLSESIVYFENSIFRMILPLSASLVQCVQRLFLLEKREGGYYQPIALLLGGLEELLEISHGYLVTEEREGYFSGSNLKGDFIQSVVSNVFSSDSSNEESKIQGERDVILQSFRQVISCCLDIWYWAHNISCKSNDDSSLDATNHNSYKFKFRSKKLLETLFLLEPLELLENLISIRSDNTTVTLVHVLDGNKPAITIPHLLYGVIIRYNRTASVKFSNRDGSRSSTTKLTKGEPSMLKRLSGESIIAFLFNYVDSVENSAMEEFYGDFLLFFREVATNYNLYSDVSLSILKLVALISGKVSKTQFGEQKRVRREISDVFFKYLPNAFINFTNLYRGHPDSFKDLEFVVWRVQYIVNDQIGGDKFNTTLATIVNQCLTPYIKPKSEKTIPGYVLELAAVVSHLGSKVKSWRLLIAELFQNDKKLSVIGSDQTWEKIIYEWSIYPENKSKILNDLLLEIGSKRSSVTPTLITFNLGSDSEVEYKCQNLLKISYLLMVSPNDAYLLHFSSLISCIFHYLVSKDIKLKGSCWILLRVLLLRFSESHFNDYWSMISYCLQTNLQEFYESLQIQSEVDPQTILQVCKTLDLLLLLNMEGFTSTNEWIFVIDTINCVYKTNSFVALVDEIAEFKDYEITKTDDLELPTTLKDGLPLLRGIHKIERHTQLRSFFQNLSYLHYEKVYGLGSVDLYGCGEDLKKDILS