wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-actinin, sarcomeric (F-actin cross-linking protein) (P18091)
Organism: Drosophila melanogaster (Fruit fly)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:17353360}. Note=Colocalizes with Smn at the Z-line of indirect flight muscles.
Interaction partners:
- Vinculin
- Paramyosin, long form
- Troponin T, skeletal muscle
- PDZ and LIM domain protein Zasp
- Myosin heavy chain, muscle
- Myosin light chain alkali
- GH23568p
- Tropomyosin-2
- Titin
- Dystrophin, isoforms A/C/F/G/H
Sequence:
MMMENGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNNTALPDERAVMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL
Protein: Double homeobox protein 4 (Double homeobox protein 10) (Q9UBX2)
Organism: Homo sapiens (Human)
Function: Transcription factor that is selectively and transiently expressed in cleavage-stage embryos. Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3'. Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites. Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes. Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis. Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats. May activate expression of PITX1. May regulate microRNA (miRNA) expression. Inappropriate expression can inhibit myogenesis and promote apoptosis.
Subcellular location: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15709750, ECO:0000269|PubMed:17984056, ECO:0000269|PubMed:21060811, ECO:0000269|PubMed:26816005, ECO:0000269|PubMed:26951377, ECO:0000269|PubMed:27378237, ECO:0000269|PubMed:28459457, ECO:0000269|PubMed:29618456}. Cytoplasm {ECO:0000269|PubMed:26816005}. Note=Actively transported through the nuclear pore complex (NPC). {ECO:0000305|PubMed:15709750}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:29618456, ECO:0000305|PubMed:15709750}.
Interaction partners:
Sequence:
MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRALLEEL
Protein: Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) (AtATE1) (Protein DELAYED-LEAF-SENESCENCE 1) (Q9ZT48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Component of the N-end rule pathway with ATE2 and PRT6. The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination. The end-rule pathway regulates various aspects of leaf and shoot development. Involved in the oxygen-dependent N-arginylation of RAP2-12, an activator of hypoxic gene expression. This N-terminal modification leads to ubiquitination by PRT6 and subsequent degradation of RAP2-12 under aerobic conditions. Has an important role in the progression of leaf senescence. Involved in disease resistance. The end-rule pathway plays a role in regulating the timing and amplitude of the immune response following infection with the bacterial pathogen Pseudomonas syringae pv tomato. Regulates the biosynthesis of plant-defense metabolites such as glucosinolates, and the biosynthesis and response to the phytohormone jasmonate (JA), which plays a key role in plant immunity.
Interaction partners:
- E3 ubiquitin-protein ligase PRT6
- Protein N-terminal glutamine amidohydrolase
- Protein N-terminal asparagine amidohydrolase
- E3 ubiquitin-protein ligase PRT1
- Plant cysteine oxidase 1
- Probable nucleoside diphosphate kinase 5
- Plant cysteine oxidase 5
- Plant cysteine oxidase 4
- Ethylene-responsive transcription factor RAP2-12
- AT4G23670 protein
Sequence:
MSLKNDASSSHDGGSNRESVIDDHGRRKSTCGYCKSPARSSISHGLSAQTLTVYDYQALIDRGWRRSGTYLYKHEMDKTCCPPYTIRLKASDFVPTKEQQRVSRRLERFLDGKLDVQPREQRGASSSGDVSDTRRKTLGAAKSEENKKVEAVMDDLSKNIDQAVQLCIRSGEFPSNMQIPKASVKKVFCARRKKLAEGTEQILYTSNIAFPIAAAIKRIQTSEKEGINSAEGNRLSPETISEMLLSAMHKVGETPDVSIKVCKGHINFLSSAKDSFSDRDVVPNGNISRGANSLDGSETLHAKKDSENHQARKRKLEIHLKRSSFDPEEHELYKRYQLKVHNDKPGHVVESSYRRFLVDSPLIDVQPSGDEKVPPCGFGSFHQQYRIDGRLIAVGVVDILPKCLSSVYLFWDPDYAFLSLGKYSAIQEINWVIENQARCPSLQYYYLGYYIHSCSKMRYKAAYRPSELLCPLRFQWVPFEVARPMLDKKPYVILSDIAISHNQCSLLAGASETLVEPAASEHEDMEQGETNDNFMGCSDEDEDEDEDDDDDDDDDEEMYETESEDSHIESDPGSKDNDINNILIGLYGSQYRYKEMRQIITPVGRKQLEPMLQSYRKVVGAELSERMVYEIN
Protein: Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) (Q93045)
Organism: Homo sapiens (Human)
Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon. Golgi apparatus. Endosome {ECO:0000250}. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}.
Interaction partners:
- Short transient receptor potential channel 5
- Vacuolar protein sorting-associated protein 26C
- RE1-silencing transcription factor
- Neuromodulin
- Stathmin
Sequence:
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
Protein: UBP9-binding protein bun107 (Binding ubp9 protein of 107 kDa) (Q09731)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.
Subcellular location: Cytoplasm. Cell tip.
Interaction partners:
- Probable ubiquitin carboxyl-terminal hydrolase 9
- UBP9-binding protein bun62
- Polyubiquitin
- Ubp5-interacting protein ftp105
- Ubiquitin carboxyl-terminal hydrolase 15
- Ubiquitin carboxyl-terminal hydrolase mug105
- Ubp4-interactor sfp47
- Ubiquitin thioesterase otu2
- Probable ubiquitin carboxyl-terminal hydrolase 1
- Ubiquitin carboxyl-terminal hydrolase 11
Sequence:
MSVRKRYKVTYVLDSCNDQLGHRLDANCLVLGRYFSEQGSAPVTRALYSGGRDGQLFGWDIGYDYGKASQPLAKIQAHSAWVNDIALTHDSEGVISCSSDSTVKLWKPHVLNASCLSTIGEHTDYVKRVSIPKYSKSPLVASGGLDKRIIVWDYNVGQEVMRFEQLPDCSLVVGPRSGVYSLAANNNIIANGGLQKDIQLWDCVSKKRITDLVGHTDNVRDILISDDGRTILTASSDATIKLWSLRAQKCLFSFIAHSDSVWALYSEHPDLKVFYAGDRSGLITRTDIRNQPNNQSCTAICKQDAPVSDIVARQSFIWSTSRDGSILRWKDEPLFNQDVGAALSKHTSSHLSVSSDCPSRHSSDIRNHSCPTLYHDDAEDIYYDLHHTESYSNINLTKTPDYVIHGGIGLLKYRMLGDRRHVLTEDAVGNKCLWDILACKQAGEFDKSEDFEKIVQSLDTVQAIPRWASVNCLLGILAVTLDENHYMDAEIYADECPLLKVDSPSDKRINLGVWILKNLFREFIDAELHRDLKFRQNLDVVRSEAKKQIEAQREEARKGNVNMPSALSPLRIRSRPSPLSLPPEPLLSPTIDYSATPFPLEPPPESPGPSLQIPSNNPVYTNLTDTDSMMGAPDYFSIPARQNRNRKPHTEVVGSPTVVRTKEIIPPKVTREGSFMGRLKKLGRSKSSKSLQTDFMKASVERAASSRVFSTGTSVTSPQALSKTNNTVNNAANTENNTLAKDKQQTSEASSPGTPRELKTTGELIEDLHEQYVHFKDKDTVLSLMKPPNDDTFPMLNLSSQITVIISEESPEAGNSRDIYRSTLENMADDIDLLENIMPFWLGRLLLLNEFPSKTAPTVNFTLQPFPGSGLPLIVNENTRLSASAMLRAQKIMDYSYSKLSQQRKDVSSLQFRCKDVVVTPKMTLATVKARIWRSGDDVVFHYDVAPRSVSEIVDKTQSLNI
Protein: Glucose-6-phosphate isomerase (EC 5.3.1.9) (Q5B093)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- ATP-dependent 6-phosphofructokinase
- Phosphoglucomutase
- Glucose-6-phosphate 1-dehydrogenase
- Fructose-1,6-bisphosphatase
- Enolase
- Transaldolase
- Mannose-6-phosphate isomerase
- Pyruvate kinase
- Phosphoglucomutase, putative
- glutamine--fructose-6-phosphate transaminase
Sequence:
MPSFSQAVELPAWKELQDHHGSVGRNIVLKECFEKDPQRFEKFSRTFQNTVDNNEILFDFSKNFLTEETLALLVKLAKQAGVEELRDQMFAGEPINFTENRAVYHAALRNVSNQPMQVNGKSVVEDVNSVLEHMKEFSEQVRSGEWKGYTGKKINTIINIGIGGSDLGPVMVTEALKPYGHPDLKLHFVSNIDGTHIAEALKDSDPETTLFLIASKTFTTAETTTNANTAKSWFLEHAKDGAHIAKHFVALSTNAEEVAKFGIDTKNMFGFESWVGGRYSVWSAIGLSVALYIGYDNFHQFLAGAHAMDKHFRETPLEQNIPVLGGLLSVWYSDFFGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKAITRTGEYVKYTTGPVLFGEPATNAQHSFFQLLHQGTKLIPADFIMAAESHNPVEGGKHQRMLASNFLAQSEALMVGKTPEQVKAEGAADNLVPHKTFLGNRPTTSILAQKITPAALGALITYYEHLTFTEGAIWNINSFDQWGVELGKVLAKKIQKELETEGEGSGHDSSTSGLLLAFKKKAKLA
Protein: cDNA FLJ42001 fis, clone SPLEN2029912 (Q6ZVW3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEAQSCEQETTARRNGGARSLKGNAAGGVVKDNICFGATSGAVTKKPSTLRKKEKFGYRETPCSKCCDSKTAGFAPLAKEPTETPGAATAKPALEGLGWRKPRTETRKLCTARLAVDTNRKVSRLLSGRKRGSKPATQWREPRSH
Protein: Cis-prenyltransferase 4, chloroplastic (SlCPT4) (EC 2.5.1.-) (K4D3U9)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Uses neryl diphosphate and geranyl diphosphate to catalyze the cis-prenyl chain elongation and produce polyprenyl diphosphate with a chain of 55 carbons.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:23134568}. Note=Localizes in punctuate patterns inside the chloroplasts. {ECO:0000269|PubMed:23134568}.
Interaction partners:
Sequence:
MAFSLQLQQIFVSYTRFCSQPKSITNPLISLKLPSIHPLAFAQNAAVSNIDTGVAAIDGSAEEVSLPPQLRRELMPKHVALIMDGNRRWAKMRGLPVALGYEAGIRAVRKIIELCGNWGIMVLTLFAFSSDNWLRPKVEVDILMSLFERALNDELENFAREGIRISIIGDSSKLPKSLQDLIAKAVKTTKENSRLHLVVAVNYSGQHDVVQACQTIAQKVKDDIIETKDINSFLIEQELQTNCIDFPCPDLLIRTSGELRLSNFLLWQLAYSELFFSHSHWPDFGEAEFLEALCSFQQRQRRYGRQSS
Protein: ER membrane protein complex subunit 6 (Q380Y6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 7 beta-sandwich domain-containing protein
- MPN domain-containing protein
Sequence:
MSLGKTIYVDKELGENVGCVSRIRIMSALVAGVGAGLLGLTNLAGALFFVVSALFTSFAILCFGCEGGPERYFPSGKKELFSFGSLFTGGMTYILAWTVAYDAIYIF
Protein: ORF136 (Q35320)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MQLCLSVTLFWLVGSAYRRVTGVLRLGCKGRNSWEIPGLKETRDIQTLGTMGNEGGAERRGCAFTKPFLEKIDFSSEANETLPQLADRIDCPESLIGWWLECISYIYLFISWLNSTVNRRIFLCNFGILKCVHFFW
Protein: AT10134p (Q8IHE0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
ALVFITIYIFKVFFSKLQFTIGIMAKVLRVNLLSVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQHQLQQQFVNLNRNYEQQISANLGSQQHGFEHNGVGVGASSSGNENCFSQYNLENITSVDMELAKLQNLQRINTLKLLHAQAQQMPLINQLLQSYAGNAIGSVGGSNLGNLMSAGGSSLMTEMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRSHRMLNYSPKVFLGGIPWDISEQSLIQIFKPFGSIKVEWPGKEQQAAQPKGYVYIIFESDKQVKALLSACVLQVDDSHCGRNYFFKISSRRIKSKDVEVIPWIIADSNFVRSSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLFDGVLYAGIDTDKYKYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTKFTKKVQVDPYLEDALCSICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIVKNHKPLTRNSKSQSLVGIGPSSSNVSLPFSGQRSIRDNRMGNGQHQQHQQHQYQQQKHRQLQEYSQPHSLNVMGNSGAANAAATSMVTLQQRQIHKVRIQRQQHQAI
Protein: Xeroderma pigmentosum, complementation group C isoform A (X5DRB1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL
Protein: Nitrogen regulatory protein GlnK1 (Q60381)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Involved in the regulation of nitrogen metabolism. Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell. Regulates the activity of the ammonia channel Amt1 via direct interaction.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B8ZYW0}.
Interaction partners:
- Ammonium transporter Amt2
- Ammonium transporter Amt1
- Nitrogen regulatory protein GlnK2
- Acetylglutamate kinase
- Uncharacterized protein MJ1187
- Uncharacterized protein MJ0572
- TPR repeat-containing protein MJ0263
- TPR repeat-containing protein MJ1428
- Uncharacterized protein MJ0875
- TPR repeat-containing protein MJ0940
Sequence:
MKKVEAIIRPEKLEIVKKALSDAGYVGMTVSEVKGRGVQGGIVERYRGREYIVDLIPKVKIELVVKEEDVDNVIDIICENARTGNPGDGKIFVIPVERVVRVRTKEEGKEAL
Protein: Nucleolar GTP-binding protein 2 (P53742)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11707418}.
Interaction partners:
- Ribosome assembly protein 4
- Eukaryotic translation initiation factor 6
- Regulator of ribosome biosynthesis
- Ribosome biogenesis protein NOP53
- Bud site selection protein 20
- Large ribosomal subunit protein uL23
- Proteasome-interacting protein CIC1
- Pescadillo homolog
- Ribosome biogenesis protein RPF2
- ATP-dependent RNA helicase HAS1
Sequence:
MGTGKKEKSRRIREGDTKDGNLRVKGENFYRDSKRVKFLNMYTSGKEIRNKKGNLIRAASFQDSTIPDARVQPDRRWFGNTRVISQDALQHFRSALGETQKDTYQVLLRRNKLPMSLLEEKDADESPKARILDTESYADAFGPKAQRKRPRLAASNLEDLVKATNEDITKYEEKQVLDATLGLMGNQEDKENGWTSAAKEAIFSKGQSKRIWNELYKVIDSSDVVIHVLDARDPLGTRCKSVEEYMKKETPHKHLIYVLNKCDLVPTWVAAAWVKHLSKERPTLAFHASITNSFGKGSLIQLLRQFSQLHTDRKQISVGFIGYPNTGKSSIINTLRKKKVCQVAPIPGETKVWQYITLMKRIFLIDCPGIVPPSSKDSEEDILFRGVVRVEHVTHPEQYIPGVLKRCQVKHLERTYEISGWKDATEFIEILARKQGRLLKGGEPDESGVSKQILNDFNRGKIPWFVLPPEKEGEEKPKKKEVEKTA
Protein: Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] (Q8BH52)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17178827}; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000269|PubMed:17178827}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus {ECO:0000269|PubMed:17178827}. Note=Upon ER stress, translocated into the nucleus. {ECO:0000269|PubMed:17178827}.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 3
- Cyclic AMP-responsive element-binding protein 1
- Cyclic AMP-responsive element-binding protein 3-like protein 3
- Cyclic AMP-dependent transcription factor ATF-6 beta
- Cyclic AMP-responsive element-binding protein 3-like protein 1
- Cyclic AMP-dependent transcription factor ATF-4
- Histone lysine acetyltransferase CREBBP
- Histone acetyltransferase p300
- Cyclic AMP-responsive element-binding protein 3-like protein 4
- Membrane-bound transcription factor site-1 protease
Sequence:
MEVLESGEQSVLQWDRKLSELSEPGETEALMYHTHFSELLDEFSQNVLGQLLSDPFLSEKSESMEVEPSPTSPAPLIQAEHSYSLSEEPRTQSPFTHAATSDSFNDEEVESEKWYLSTEFPSATIKTEPITEEQPPGLVPSVTLTITAISTPFEKEESPLDMNAGGDSSCQTLIPKIKLEPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSLSPNPRLHPFSLSQAHSPARAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLVAEGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHPLSEPYTASVVRSRNLLIYEEHAPLEESSSPASAGELGGWDRGSSLLRASSGLEALPEVDLPHFLISNETSLEKSVLLELQQHLVSSKLEGNETLKVVELERRVNATF
Protein: Protein IMPACT homolog (O13997)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn2 kinase activity; impairs gcn1-mediated gcn2 activation, and hence gcn2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis. In normal conditions, it resides in a actin complex and has no activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- RWD domain-containing protein C1393.09c
- Uncharacterized ABC transporter ATP-binding protein C29A3.09c
- V-type proton ATPase catalytic subunit A
Sequence:
MENNEEFQDELLALESIYPSCLLPISEQSFTYTLSIPDSSVRLNIQFPLDYPNSAPTVLDAYGIDKTLAEDVLLSVATGDVCIFSYMDLLKELVDIDAEQAAAERESKLQEESDKETPVMLNKSHYVAKTPEIQDEPWKPKFDWKESEPITDRKSTFMAHATRVYSTEEVREALEDLYMDKKVAKANHNMVAYRIISPNGNVIQDNDDDGESAAGSRMSHLLTMMSAENVFVCVSRWFGGVHIGPDRFKHINSSAREAVLLTDAAPSQKKGTEHGKKKKK
Protein: Coiled-coil domain containing 198 (E9PSE9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGLSHSKTHLRVIKVAPLQNKEVETPSAGRVDFAFNQNLEEKTSYSLARLQDQNKALEGQLPPLQENWYGRYSTASRDMYFDIPLEHRETSIIKRHPPQRLQKLEPIDLPRVITSGRLLSQREARTMHKAKVLEKKMQTPMYTSENRQYLHKMQVLEMIRKRQEAQMELKKSLHGEARINKQSPRDHKAKKTLQSTPRNDDHDLLTMLPDEILNRGPGNSKNTEFLKHQAVNNYCPWKIGKMETWLHEQEAQGQLLWDSSSSDSDEQGKDEKKPRALVRTRTERIPLFDEFFDQE
Protein: PHD finger protein 8 (H0Y589)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMSRLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEVEFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQVKKMKLSLTDSG
Protein: MAP kinase kinase (Eurofung) (Q5B7Q8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Mitogen-activated protein kinase
- mitogen-activated protein kinase kinase kinase
- Mitogen-activated protein kinase kinae kinase bck1
- mitogen-activated protein kinase
- Mitogen-activated protein kinase mpkC
- Mitogen-activated protein kinase hog1
- High osmolarity signaling protein sho1
- mitogen-activated protein kinase kinase
- Protein kinase domain-containing protein
- Uncharacterized protein
Sequence:
MADQFKARTLKRKNVKGLALNAAPKSTSTLSNGDSQVPGAAGNGESNRTDTLEIGLEFRLDLRSEDLITLKELGAGNGGTVSKVMHASTKVVMARKIIRVDAKENVRKQILRELQVGHDCNSPNIVTFYGAFQNEARDIVLCMEYMDCGSLDRISKDFGPIRVDVLGKITESILAGLVYLYEAHRIMHRDIKPSNVLVNSRGNIKLCDFGVATETVNSIADTFVGTSTYMAPERIQGGAYTVRSDVWSVGLTVMELAVGRFPFDTTDSAAGDRASAGPMGILDLLQQIVHEPAPKLPRSDAFPPVLHEFVAKCLLKKSEERPTPLELYEKDAFLAAAKRTPVDLQEWAISMMERHNRKSYLAPPAPKSLKETRESPSPAQAPSPVQKHGTSRPSRGTTGEIPLNVARDSSSHQRQHAPQSQSHFSSNPSHYSSNSSHYSSRSSRSSPPISLEHLSLESKQDEHRPTRRPSRTPLGDSSSSLDQSLRPSIGSRSASSHNTNSRMPLQSTALPFRVAPTPGGYPTPNSTSWQRRGDHMGAL
Protein: Integrin alpha-PS5 (Position-specific antigen subunit alpha-5) (Q9W1M8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin beta-PS
- Integrin beta-nu
- Integrin alpha-PS1
- Integrin alpha-PS4
- Integrin alpha-PS2
- Integrin alpha-PS3
Sequence:
MNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTSIFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAPRFFVPKNKNYGQMRGICYWVRDTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQETITVTACYRLETTSKARQMQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCAAHVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEGNQEEINVEMHSDLEN