wanglab/gogpt-training-data huggingface dataset:
Protein: Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5) (Q5TGI4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28388653}.
Interaction partners:
- SAM and SH3 domain-containing protein 1
Sequence:
MCTNIVYEWLKALQLPQYAESFVDNGYDDLEVCKQIGDPDLDAIGVLAPAHRRRILEAVRRLREQDANAAGLYFTLEPQPAPPGPPADAVPTGRRGEPCGGPAQGTRGDSRGHTTAPRSRELVSYPKLKLKIMIRDKLVRDGIHLSKPPYSRKVPMAGILEYLMNWPKSSQSR
Protein: A1 cistron-splicing factor aar2 (Q6LA53)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor brr2
- LIN1-like protein
- Pre-mRNA-splicing ATP-dependent RNA helicase prp28
- Protein ecdysoneless homolog
- Pre-mRNA-splicing factor cwf17
- Small nuclear ribonucleoprotein-associated protein B
- Ubiquitin-like modifier hub1
- Small nuclear ribonucleoprotein Sm D3
Sequence:
MSIEFVGWLNTYYVGIDQSSYEASKLPGIRNVKGGIHLFTWSPTYPAGLISGVFAMVHEDMKYSIDFDSKSETASLQKLDVLYDENFYPFESTKDWDLLTKFITVQDLQRIFATEGEFFYLDTSTYVNADLVSQDPEFSKPSRDDKLLNFAEFNLRRSWSPSATGPERSKQAIDKSFLFQRLVQSVWNDNPISALAELSISFLSYSILSHYGALEHWKNMLSLLLQSYELAETEPEFYASFLELFKLQLSSLSESDLETSAIFEKGVLLSCLDSLSERKVDGSFGSLVNEAIENLLKTISELLNSHEEQAGLMQKGDLYSAADYEAEVHETGDYVIDVSTEEDPIH
Protein: Cation/H(+) antiporter 21 (Protein CATION/H+ EXCHANGER 21) (AtCHX21) (Q9SKA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Operates as a Na(+)/H(+) antiporter that plays a role in regulation of xylem Na(+) concentration and, consequently, Na(+) accumulation in the leaf. Required for pollen tube guidance, but not for normal pollen development. May also be involved in the development or function of the female gametophyte.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16513816}; Multi-pass membrane protein {ECO:0000269|PubMed:16513816}.
Interaction partners:
- Sodium/hydrogen exchanger 8
- Potassium channel AKT6
- Subtilisin-like protease SBT3.17
- Membrane lipoprotein
- COBRA-like protein 10
- Inositol transporter 4
- Transcription factor MYB97
- K
- F-actin-capping protein subunit alpha
- Cyclic nucleotide-gated ion channel 18
Sequence:
MADPAAESIDASSSRFGRVVCYNQTAMHGSNTISAAAPFFMTQLSVANLTYRILYYFLKPLCLPPFVAQILCGLLFSPTVLGNNEVVLKLIFPYKYTMLLETFANLALVYNVFLLGLGLDLRMIKIKDIKPVIIAIVGLLAALLAGAGLYYLPSNGEADKILAGCMYWSIAFGCTNFPDLARILADLKLLRTDMGHTAMCAAVVTDLCTWILFIFGMAIFSKSGVRNEMLPYSLASTIAFVLLCYFVIQPGVAWIFNNTVEGGQVGDTHVWYTLAGVIICSLITEVCGVHSITGAFLFGLSIPHDHIIRKMIEEKLHDFLSGMLMPLFYIICGLRADIGYMNRTVSVGMMAVVTSASVMVKILSTMFCSIFLRIPLRDGLAIGALMNTKGTMALVILNAGRDTKALDVIMYTHLTLAFLVMSMVVQPLLAIAYKPKKKLIFYKNRTIQKHKGESELCVLTCVHVLPNVSGITNLLQLSNPTKKSPLNVFAIHLVELTGRTTASLLIMNDEAKPKANFADRVRAESDQIAEMFTALEVNNDGVMVQTITAVSPYATMDEDICLLAEDKQACFILLPYHKNMTSDGRLNEGNAVHAEINQNVMSHAPCSVGILVDRGMTTVRFESFMFQGETTKKEIAMLFLGGRDDREALAYAWRMVGQEMVQLTVVRFVPSQEALVSAGEAADEYEKDKHVDEESIYEFNFKTMNDPSVTYVEKVVKNGQETITAILELEDNNSYDLYIVGRGYQVETPVTSGLTDWNSTPDLGIIGDTLISSNFTMQASVLVVQQYSSANRQTAENNNQEPVQGKAKTDHEATPFMEDEDDEVEHQYSMRR
Protein: Aromatic ring hydroxylation dioxygenase A (Benzoate 1,2-dioxygenase ISP alpha subunit) (Q932V1)
Organism: Rhodococcus jostii (strain RHA1)
Interaction partners:
Sequence:
MTDTLYTAPSDDVRAKLADALIEDAETGRYQVRRSVFTDEDLFELEMKHIFEGNWIYLAHESQIPNVGDYFTTYMGRQPIVISRNKEGELNALVNACSHRGAMLCRRKTDNRTTFTCPFHGWTFNNSGKLLKVKDPREAGYPEQFNKDGSHDLTKVARFENYRGFLFGSLNADVPPLEEHLGDTTKIIDMIVDQSPDGLEVLRGASTYTYDGNWEAADENGADGYHVSATHWNYAATTSAWESGESTNATKAMDAGKWSKQQGGYYSFDNGHLLLWTKWADPANRPLNERRDELVAEYGEDRADWMIGVSRNLCLYPNVYLMDQFGSQIRHFRPISVDKTEVTIYCIAPKGESRTARAARIRQYEDFFNATGMATPDDLEEFRSCQKTYQAGAAPFNDLSRGVTHQLQGPDEESKKIGINPIVRGVKTEDEGLYPIQHGYWVQALTKALDADVAANNR
Protein: Lysine histidine transporter-like 4 (Q9SS86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Amino acid transporter.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase UPL7
Sequence:
MAGIPDHIQDQHLVEEDQPFDLEDWLPITASRNANWYYSAFHNVTAIVGAGVLGLPYAMSELGWGPGVVVLILSWVITLYTLWQMIEMHEMFEGQRFDRYHELGQAAFGKKLGLYIIVPLQLLVEISVCIVYMVTGGKSLKNVHDLALGDGDKCTKLRIQHFILIFASSQFVLSLLKNFNSISGVSLVAAVMSVSYSTIAWVASLRKGATTGSVEYGYRKRTTSVPLAFLSALGEMAFAYAGHNVVLEIQATIPSTPENPSKRPMWKGAVVAYIIVAFCYFPVALVGFKTFGNSVEESILESLTKPTALVIVANMFVVIHLLGSYQVYAMPVFDMIESVMIRIWHFSPTRVLRFTIRWTFVAATMGIAVGLPYYSALLSFFGGFVFAPTTYFIPCIMWLILKKPKRFSLSWCMNWFCIIFGLVLMIIAPIGGLAKLIYNIQKGTLPNSRCNLPKH
Protein: Metallo-beta-lactamase family protein (Q8RWE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein LURP-one-related 15
- At4g24090
- LRR receptor-like serine/threonine-protein kinase RGI2
- 10 kDa chaperonin 2, chloroplastic
- Outer envelope pore protein 16-1, chloroplastic
- Lactoylglutathione lyase
- Probable lactoylglutathione lyase, chloroplastic
- Transmembrane ascorbate ferrireductase 1
Sequence:
MASASFSAVSSLSYQFRSKEAIFSSKASCFSSTALSGRRVFGSIKAAQVTSHENPRRRTQNVEGDIFVDNTCIDCDTCRWMVPDLFTRVDNMSAVTKQPTCKEERLNALQALLSCPTGSIRTQTPPADIGEAQETFPLVVDKDTLPGVFHCGFHSKKSYGATSYLILHREGNILVDSPRYVEKLAGKIEMKGGVRYMFLTHRDDVADHKKWADRFKSTRILHSDDVEPSTSDVELKLEGSGPWSIYEDVELIHTPGHSEGSVCMFHKSLKALFTGDHVIMTESGLSILEQYNHGSVPLQLENVEKLINLDFNWLIPGHGRRVHFKDGDEKAKNLEALVQKHREKQLVSFSKSGKA
Protein: Protein spaetzle (Protein spatzle) [Cleaved into: Protein spaetzle C-106] (P48607)
Organism: Drosophila melanogaster (Fruit fly)
Function: The activated form, spaetzle C-106, acts as a ligand for the Toll receptor. Binding to Toll activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo.
Subcellular location: [Isoform 8.19]: Secreted. Note=Secreted in a cell culture system.; SUBCELLULAR LOCATION: [Isoform 8.29]: Secreted. Note=Secreted in a cell culture system.; SUBCELLULAR LOCATION: [Isoform 11.15]: Secreted. Note=Secreted in a cell culture system.; SUBCELLULAR LOCATION: [Isoform 11.6]: Secreted. Note=Secreted in a cell culture system.; SUBCELLULAR LOCATION: [Isoform 11.7]: Secreted. Note=Secreted in a cell culture system.
Interaction partners:
- Protein toll
- Spaetzle-processing enzyme
- Serine protease ea
- NF-kappa-B inhibitor cactus
- LD20892p
- Dorsal-related immunity factor Dif
- Toll-like receptor 7
- Serine protease persephone
- Modular serine protease
- Protein immune deficiency
Sequence:
MMTPMWISLFKVLLLLFAFFATYEAKEYERIIKELFTITNDEGVVLFNTSADSAPFMPIPTQHDDPTQKQKQNQNQSPIPETNRHYHQYHSLIQPDQYFKVQRSPNGKLNLVFNDTFVSLQRTDTEVQSEQPIPPRHPSDTFVFPDSPIAKYRPPQSPARPLRNDTKEHNPCAKDESQHLRNFCTNVDDYPDLSGLTHKLKNNFAKFFSNDLQPTDVSSRVGGSDERFLCRSIRKLVYPKKGLRADDTWQLIVNNDEYKQAIQIEECEGADQPCDFAANFPQSYNPICKQHYTQQTLASIKSDGELDVVQNSFKIPSCCKCALKTG
Protein: Putative cryptic C4-dicarboxylate transporter DcuD (P45428)
Organism: Escherichia coli (strain K12)
Function: May have a role in the transport of dicarboxylates from the periplasm across the inner membrane. Seems not to be essential for growth. It is likely to be a cryptic gene, as no or low expression has been found under a number of growth conditions and when tested with a large number of potential substrates.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Anaerobic C4-dicarboxylate transporter DcuB
Sequence:
MFGIIISVIVLITMGYLILKNYKPQVVLAAAGIFLMMCGVWLGFGGVLDPTKSSGYLIVDIYNEILRMLSNRIAGLGLSIMAVGGYARYMERIGASRAMVSLLSRPLKLIRSPYIILSATYVIGQIMAQFITSASGLGMLLMVTLFPTLVSLGVSRLSAVAVIATTMSIEWGILETNSIFAAQVAGMKIATYFFHYQLPVASCVIISVAISHFFVQRAFDKKDKNINHEQAEQKALDNVPPLYYAILPVMPLILMLGSLFLAHVGLMQSELHLVVVMLLSLTVTMFVEFFRKHNLRETMDDVQAFFDGMGTQFANVVTLVVAGEIFAKGLTTIGTVDAVIRGAEHSGLGGIGVMIIMALVIAICAIVMGSGNAPFMSFASLIPNIAAGLHVPAVVMIMPMHFATTLARAVSPITAVVVVTSGIAGVSPFAVVKRTAIPMAVGFVVNMIATITLFY
Protein: ATP synthase subunit 9, mitochondrial (Q2F919)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion membrane {ECO:0000256|RuleBase:RU004221}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004221}.
Interaction partners:
Sequence:
MLEGAKSIGAGAATIALAGAAVGIGNVLSSSIHSVARNPSLAKQLFGYAILGFALTEAIALFAPMMAFLISFVFR
Protein: Probable calcium-binding protein CML20 (Calmodulin-like protein 20) (Centrin 1) (AtCEN1) (O82659)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- SAC3 family protein B
- Ubiquitin receptor RAD23b
- DNA repair protein RAD4
- Probable ubiquitin receptor RAD23a
- Transcription and mRNA export factor ENY2
- Ubiquitin receptor RAD23d
- Ubiquitin receptor RAD23c
- SAC3 family protein C
- Protein DAMAGED DNA-BINDING 2
- SAC3 family protein A
Sequence:
MSSIYRTVSRKEKPRRHHGLTTQKKQEIKEAFELFDTDGSGTIDAKELNVAMRALGFEMTEEQINKMIADVDKDGSGAIDFDEFVHMMTAKIGERDTKEELTKAFQIIDLDKNGKISPDDIKRMAKDLGENFTDAEIREMVEEADRDRDGEVNMDEFMRMMRRTAYGGN
Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) (Q9V3I1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Thymidylate synthase
- Thymidylate kinase
- Probable deoxycytidylate deaminase
- Proliferating cell nuclear antigen
- Inosine triphosphate pyrophosphatase
- Ribonucleoside-diphosphate reductase large subunit
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase-like domain-containing protein
- FI21821p1
- Nucleoside diphosphate kinase
Sequence:
MPSTDFADIPAAKKMKIDTCVLRFAKLTENALEPVRGSAKAAGVDLRSAYDVVVPARGKAIVKTDLQVQVPEGSYGRVAPRSGLAVKNFIDVGAGVVDEDYRGNLGVVLFNHSDVDFEVKHGDRIAQFICERIFYPQLVMVDKLEDTERGEAGFGSTGVKDLPAAKAQNGNGEKAAEPEGAAPAPVAT
Protein: Nudix hydrolase 10 (AtNUDT10) (EC 3.6.1.-) (ADP-ribose pyrophosphatase) (EC 3.6.1.13) (NADH pyrophosphatase) (EC 3.6.1.22) (Q6NPD7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May mediate the hydrolysis of some nucleoside diphosphate derivatives. In vitro, uses both ADP-ribose and NADH as substrates; however the relevance of such substrates in vivo is unclear.
Interaction partners:
- Nudix hydrolase 1
- Nudix hydrolase 11
- Nudix hydrolase 25
- Nudix hydrolase 4
- Nudix hydrolase 9
- Nudix hydrolase 19, chloroplastic
- Nudix hydrolase 3
- Nudix hydrolase 24, chloroplastic
Sequence:
MSDQEAPLRNGVEHKIFEVLPFVDDDYGGVIVEMKTPMDTKNFVAALRDSFEQWRLQGKKGVWLNLPLSHVNLVEPAVKEGFRYHHAEPTYLMLVYWIPEAESTIPLNASHRVRVGAVVLNHNKEEKYGSLCGSGIWKIPTGVVDEGEEIFAAAIREVKEETGIDTEFLEILAFCQTHESFFAKSDLFFVCLLRPTSFDIQKQDLEIEAAQWMRFEDSASQPITHKNDLFKDIHHICSMKMEKSYSGFSKKPITTFFDDKLGYLYLNKQEDMEQPIS
Protein: Putative transcriptional regulator (Q936X4)
Organism: Pseudomonas sp. (strain ADP)
Interaction partners:
Sequence:
MRAQRPSAIQAISIPSFLLRPPMQHLRFLHYIDAVARCGSIRAAAEQLHVAASAVNRRVQDLEYELGTPIFERLPRGVRLTAAGELFVAYARRRNADLEQVQSQIQDLSGMKRGRVTLAASQALAPEFLPRVIHAFQAQRPGIAFDVKVLDRERAVLAVTDFAADLALVFNPPDLRGLTVIAQARQRICAVVASDHPLAKRTSLRLKDCLDYPLALPDSSLSGRNVLDELFDKSSARPRPQLVSNSYEMMRGFARETGGVSFQIEIGAGSTEGEVAIPIDERSLASGRVVLVALRERVLPVASAAFAEFVAGKLADTTHNAT
Protein: E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Erythroblast macrophage protein) (Macrophage erythroblast attacher) (Q4VC33)
Organism: Mus musculus (Mouse)
Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17071116}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7L5Y9}. Nucleus matrix {ECO:0000269|PubMed:17071116}. Cell membrane {ECO:0000269|PubMed:17071116}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16707498, ECO:0000269|PubMed:17071116}. Note=Detected in a nuclear, speckled-like pattern (PubMed:17071116). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (By similarity). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages (PubMed:17071116). Colocalizes with F-actin in macrophages (PubMed:16707498). {ECO:0000250|UniProtKB:Q7L5Y9, ECO:0000269|PubMed:16707498, ECO:0000269|PubMed:17071116}.
Interaction partners:
- Armadillo repeat-containing protein 8
- WD repeat-containing protein 26
- E3 ubiquitin-protein ligase RMND5A
- E3 ubiquitin-protein transferase RMND5B
- Ran-binding protein 9
- Glucose-induced degradation protein 8 homolog
- Ran-binding protein 10
- Muskelin
- Glucose-induced degradation protein 4 homolog
- Vitronectin
Sequence:
MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSSCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASMWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELVRQNKRLDAVRHARKHFSQAEGSQLDEVRQVMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNSSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
Protein: Ascaphin-5 (P0CJ29)
Organism: Ascaphus truei (Coastal tailed frog)
Function: Antimicrobial peptide. Synthetic peptide shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very week hemolytic activity.
Subcellular location: Secreted.
Interaction partners:
Sequence:
GIKDWIKGAAKKLIKTVASHIANQ
Protein: Condensin complex subunit 2 (Q9VIP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein
- Chromosome associated protein G, isoform F
- Structural maintenance of chromosomes protein
- Condensin-2 complex subunit
- Chromosome associated protein H2, isoform E
- DNA topoisomerase 2
- Structural maintenance of chromosomes protein 5
- Structural maintenance of chromosomes protein
- Aurora kinase B
Sequence:
MTLPRLETPLRRSAVGSYQEGVSRMLTPFNDDEAERREARRRTLLQQHHRSSTLESIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHHKRMSNFKMAGSSLEASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQGEQATGEGQDSAQQAAKEAAPKPKRQKKPISTVTKNRETLNSRLDTAPLQDPVFGKLNSTVGSINASNRLMHNILPSFDSELRLRTTYNFWNSEESTEEVQDHTTLNAEMEQWPATSLMSTNLMRKLLPHAERSNLRPLHTGYIITSAPNPKSANEKAAEVVQDEDHDEGLDNADDMCVNEISMAFDINAECEPMPDLDGPPPLVLEVDSNELEELTAEEQMVINNCRRLRKQTEFIEDLRPVDGNSKLEYSYRPMDQISQFWAGPSHWKFKRTRPRSTFSQTNGQVDTQPIRTQRAKKSAHLNANRRAKALDYGNVTENFFQQLDTTIRQRKANFQKKWDPRKLILPTKFELDPDLFFKYESAPSIKLSKRAGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVIAAIAAEQAAEASMMNVSAGEIGLTQMNATCNNTVFEIGTEFEGAPSQVAKVIVPFAKRAKVIDMKNLKKSCNSLIQKQLLNAVPEETIPSHPKKKGEHYSKGFASFQQVYQKLPDLLTTKMSDSLSPSVAFYAVLHLANDLKLRLIPQEDLEDFQIRQVLD
Protein: LDL receptor related protein 8 (D3ZE75)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
- Reelin
- Disabled homolog 1
- Apolipoprotein E
- Very low-density lipoprotein receptor
- Apolipoprotein B-100
- C-Jun-amino-terminal kinase-interacting protein 1
- C-Jun-amino-terminal kinase-interacting protein 2
- Spondin-1
- Beta-2-glycoprotein 1
- Clusterin
Sequence:
MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISSYDRPLWAEPCLGETRDLEDPAPAHKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP
Protein: Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) (Q99567)
Organism: Homo sapiens (Human)
Function: Component of nuclear pore complex.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:30543681}.
Interaction partners:
- Nuclear pore glycoprotein p62
- Nuclear pore complex protein Nup214
- Nuclear pore complex protein Nup98-Nup96
- E3 SUMO-protein ligase RanBP2
- Nuclear pore complex protein Nup85
- Exportin-1
- Nucleoporin NUP35
- Nuclear pore complex protein Nup205
- Nuclear pore complex protein Nup155
- Nuclear pore complex protein Nup153
Sequence:
MAAAEGPVGDGELWQTWLPNHVVFLRLREGLKNQSPTEAEKPASSSLPSSPPPQLLTRNVVFGLGGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLLCINPPLFEIYQVLLSPTQHHVALIGIKGLMVLELPKRWGKNSEFEGGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYPSEILDPHVVLLTSDNVIRIYSLREPQTPTNVIILSEAEEESLVLNKGRAYTASLGETAVAFDFGPLAAVPKTLFGQNGKDEVVAYPLYILYENGETFLTYISLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVLEGEEEDDHTSEKSWDSRIDLIPSLYVFECVELELALKLASGEDDPFDSDFSCPVKLHRDPKCPSRYHCTHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELSTEQKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTMICITSTYECLIWPLLSTVHPASPPLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVNF
Protein: ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (MIG-6) (Q99JZ7)
Organism: Mus musculus (Mouse)
Function: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16648858}. Cell membrane {ECO:0000269|PubMed:16648858}; Peripheral membrane protein {ECO:0000269|PubMed:16648858}; Cytoplasmic side {ECO:0000269|PubMed:16648858}. Nucleus {ECO:0000305|PubMed:16648858}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
Interaction partners:
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
Sequence:
MSTAGVAAQDIRVPLKTGFLHNGQALGNMKSCWGSHSEFENNFLNIDPITMAYNLNSPAQEHLTTVGCAARSAPGSGHFFAECGPSPRSSLPPLVISPSESSGQREEDQVMCGFKKLSVNGVCTSTPPLTPIKSCPSPFPCAALCDRGSRPLPPLPISEDLCVDEADSEVELLTTSSDTDLLLEDSAPSDFKYDAPGRRSFRGCGQINYAYFDSPTVSVADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDEDKPEVPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSANKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKYFKEAEETNPSTQIQPLPAACGMASATEKLASRMKIDMGSHGKRKHLSYVVSP
Protein: Mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (LmxMKK5) (Q0PKV7)
Organism: Leishmania mexicana
Function: Protein kinase which phosphorylates and activates MPK4 in vitro.
Interaction partners:
Sequence:
MSRLKINLDAIERDGASATEGFCADGVRIGSLLVSSEGVRDNQGNLCVLSLSDLEVVPETEGGFLGKGSSGSVRRAVHRGSNKVVALKEIKVTGQTHINEIRRELETLHAGDFATPYLVSFYGAFAHEGSVFIAMEAMDGSLHELYKPVPPPVLACITRLMLKGLTYLHRNRHLIHRDLKPSNVLYNSRTGDIKISDFGVSSNLECTKADAHSFVGTVTYMSPERLRGEHYSYGADIWSLGLVVAELAVGVCPYAGLRGGSSEARFWALLQHLNGDGTALELPPEMDSDLADFISACVVKSPDRRPTCTELLRHPFIVRYTGAAPEAEAKPFSTTTPTVLAPGGLSSLLNRASPAAGSALPLASEGGTPKATSPSPAPVSPLTLSCPLERHDGETDADIADRTVVARWIHAVMKRAVLHKARGHGREELHQEPLAAVSASVATDSGEGGGAAGVSAASLDNGQAAQHREFRAERNLDGHSGDGGSAPVEEDCTAGVRSLTCDDLRWTSTGEPSVNLDDELNRLLF
Protein: Desmin (P48675)
Organism: Rattus norvegicus (Rat)
Function: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:23615443}. Cytoplasm {ECO:0000250|UniProtKB:P17661}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P17661}. Nucleus {ECO:0000250|UniProtKB:P31001}. Cell tip {ECO:0000250|UniProtKB:P31001}. Nucleus envelope {ECO:0000250|UniProtKB:P31001}. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes. Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes. Interacts with ASB2; the interaction targets DES for proteasomal degradation (By similarity). PKP2 is required for correct anchoring of DES at the cell tip and nuclear envelope (By similarity). {ECO:0000250|UniProtKB:P17661, ECO:0000250|UniProtKB:P31001}.
Interaction partners:
- Vimentin
- Uncharacterized protein.
- Myosin light chain 1/3, skeletal muscle isoform
- Histocompatibility 2, class II antigen E alpha
Sequence:
MSQAYSSSQRVSSYRRTFGGAPGFSLGSPLSSPVFPRAGFGTKGSSSSVTSRVYQVSRTSGGAGGLGSLRASRLGTTRAPSYGAGELLDFSLADAVNQEFLATRTNEKVELQELNDRFANYFEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEEMRELRRQVEVLTNQRARVDVERDNLIDDLQRLKAKLQEEIQLREEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTFSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL