wanglab/gogpt-training-data huggingface dataset:
Protein: Intraflagellar transport protein 140 (Q388F5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
- WD repeat-containing protein 19
- Intraflagellar transport protein 122 homolog
- Uncharacterized protein
- Uncharacterized protein
- Intraflagellar transport protein 80
- Intraflagellar transport protein IFT88, putative
- Intraflagellar transport protein component, putative
- IFT80/172/WDR35 TPR domain-containing protein
- C2H2-type domain-containing protein
- Intraflagellar transport protein 57/55
Sequence:
MSLYFVNNIASRGAVSATHVVAHPQLPLVASVWTNPLHVLVTDSEGESVADHTPKPQSQSDGTKATDDVTCLAWHPARPVLAIGTRSGKLLVWTLPPTKPTDANFTLHPPVDVESARVQHVNGSVTACEWSGSGAYLVTAADSKRAVMWVFDSGATAAEGEADSAGKPASHSTVAPQWSVTTDETVTHAMRVSTPPVVARERSQRQQRKPAAEGENAEGSTTANLQAAGLDDGESECVFILASSKGKTIFGLSEEQKLFPLATMEETAAAVLYDPVERYLVALSLTHMLTVYRVTPTIVAELVMRRKLSIPVPGASANRNPLAMEWVSAGVLVFGCGDDRVRFFNVQSDRMYVVMHPSAPSAHVVHIATLTKKGLLVMATAEGSVAVFQKPSFVCQGSSSPYDAMGVSAFDVGMRSGSAASSNAFNKGTEKAGAFESNGDPAAEWELLTVVKVEDRVERLCFSGNNYIYVTLSNGKLQMLRETVRKRAWDGVAAATQISMEVAVVESVTGCQCLLKSSSKIYGVSIAFPIIGLWNGYQIDLYTVNEATSTATLTSSVPSKNPAFAIHQSGIFYVRDTHRIVFSSFQMIMIGQIAFTEAEGVPTLVDVMSDVVVALSSENAMRLAIVNSNEVTPLGPPRLLPKLGNDLVVTSIKVNAEGRRVALMARCVSNDQPDTRVWVYDADTDLMFSYDFMERMEIPHAVYWNTPEPNGNSLGEPGYLLLACETHQLKGVSQPDEQKPTGPQGNVDGRDTCSPPEHRESGVRSPKRTSQPTESKSKEATNGAMPDLENFADAKGKSAAEDAENGFSAVNPLAHRSHNLVTLFATNRGLVVHNSVELKRYHICLVGLTIPDFLLTSVRINGDPGNPEDYMIEQKRLRDFEGLKTEKDAAVLEALMKFSYYSTVGNMDEAYRCVKTIKTATVWQSLAKMCVASGRLDVASVCLAQMQDGVAASALRVARTNYPGEKEVQVATLACSLGLVRECEELLRKAKRFDLITDLFIACGKFEQAQRHAREHDRIRVYPVAYKYAQFMESFSNFDAAVMWYCNARCLDTDVVRLYFQNGRLSDLRLLVTPPEKKRESAEVATVDKGRSNAEAEAPANPASSLTDPKSVGIAGDGEVRAASAGGNPKSDDRGHDDNQVQPILQKLFAHNPELLHWWARQAERRKKFSEATNFYTLAGDVFNTVRLLFNESPPKTQEAIDIVDNEIKKRRSEAESSRTPLMQSSPNQSIEPVGAAYFVGKHYERNGDVTSALKYYQHAGAWRAAAKVAKSHERHSELLTIAQNSEDTHLMLDCAAFLEHNGVYEMSVDLYHRIGDIQKAIDVCIKGKQYDAMHRISSTLNAEKDAEVFLQMASHFVESGHYTKAAEMYIFAREYPSALTLCVERGVGLTDEMADAITAEAKRRQLSDDQKTELERQIAGIARDQGNWNLACRKYTQLGERVKAMKMLMRGGDVKKVIFFANHSRSTEIYTLAGNFLQSQNWHTDANIHKHIVLFYTRSKAFTNLISYIDSYAQLQIDENRNYYDAWCALDECIGQVERNRDAMCDVNITGKMEGLRVRRDIVAQAVKAVKLLADSGKGEEQAKEFIAVCSDLVKRSRPSHKDHADITSSIRIGDIFALLVRHYHENMKASTDAMRVIDSMVKHGAEPQFFVERDLLESVCKSNGRRLSEFVSGDNITDNTKDDGVKGGRQMEGI
Protein: Actin-related protein 6 (hArp6) (hARPX) (Q9GZN1)
Organism: Homo sapiens (Human)
Function: Required for formation and/or maintenance of proper nucleolar structure and function. Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P45890}. Nucleus {ECO:0000269|PubMed:16487625}. Nucleus, nucleolus {ECO:0000269|PubMed:26164235}. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin. {ECO:0000269|PubMed:16487625}.
Interaction partners:
- Helicase SRCAP
- RuvB-like 1
- Zinc finger HIT domain-containing protein 1
- RuvB-like 2
- DNA methyltransferase 1-associated protein 1
- Histone H2A.Z
- E1A-binding protein p400
- Vacuolar protein sorting-associated protein 72 homolog
- YEATS domain-containing protein 4
- Splicing factor 3B subunit 4
Sequence:
MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI
Protein: 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) (Q62758)
Organism: Rattus norvegicus (Rat)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q13639}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P97288}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250|UniProtKB:P97288}.
Interaction partners:
- Pro-opiomelanocortin
- VIP peptides
- Gastric inhibitory polypeptide
- Pro-glucagon
- Pituitary adenylate cyclase-activating polypeptide
- 5-hydroxytryptamine receptor 7
- Natriuretic peptides A
- Neuroendocrine secretory protein 55
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
Protein: Dendrite extension defective protein 1 (P41950)
Organism: Caenorhabditis elegans
Function: Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. Promotes seam cell remodeling during the dauer phase. Plays a role in positively regulating locomotion during the dauer phase.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:19344940}. Secreted {ECO:0000269|PubMed:30409788, ECO:0000305|PubMed:19344940}. Note=Located at dendritic tips. When transmembrane anchor domain is absent, secreted in vitro. {ECO:0000269|PubMed:19344940, ECO:0000305|PubMed:19344940}.
Interaction partners:
- Protein dyf-7
- Cuticlin-5
- PAN domain protein
Sequence:
MLAHTHRINKCLYGQNQMRNRHALLGALPPIFLLLLPLISCMKFDPERIAARLRIDEKWDQLDAFQSIKSRRGRQIQPKEISIQVTAPLFSSRLFDYGTTAGDEELPQALDVGKKLDLVHPISFFGSDYKTIYILSNGAVGFEASSRSYKSGILPSSTRFLAPFWNRNDLRNGGKVYYREVTKGRVLERGQSEIRYQYDKNVKVKSALIITWDKMQPLNTAALPEENTNTFQAAIFITANGTFANFIYSNIGWTQGAEAGFNAGDATNHFKLPTSGTPNIMYLEEYGNTGIPGEWMFELSELRVISCKSGIKGDTCDQECSNGEWGPDCAYCCHCSEGTCHPISGDCQRGCATCWDGVACQTRQEKCATKTQCASNALSFNDYDRCGEPIQRCQCLNGYKGDGYNNCEDVDECKTNSTICHKNAICTNTPGRYFCMCKEGFSGDGQNDCSQSFLFQYDTHHQLPRKKNSKMEWNLKKPLKIFGETTEKLTVTSTGLIAINEVNRDNGRLEDMQLVGIAPFFGPIDLSRNGAVSVEEVDDVEVLRRVTRTIGENYNDPTFVAKSALVVTFSNVTDGRQTKGNTFQALLIDGSNSKNEKMTFVELMYRDLPWASGAEAGILSSDASSSILLPASGTEAISQLSKNSNIKQPGTWLYRIDKAQLMPCAQPIQVPPYCDRLLSTAPRLPSKLLEEKKEGLTLPSPGAFLVDQPSETIVPTLVRGGGTVTRGRNVLTVTTSPIGNQQRQQTTKAVTRPRPNFSSTPHRPIVSLSDEDFELGPDAFEVTFPPFVTVQPELFRPNQRNGVQKSTQRPLPDFSIRTPLKEEATTSVPREKTSSAAPAHSPIEEMSENEESPFEAGSFDGEAVKFNEELEAIDKALQTTKKQRPELSVTPQPEDLSGDARVIETTEEDEEEAEISTETTTEMSSTTTTTKAHTTTTTMMIPTEAPPSIFVFTTTQKPRAQSTTQKRIIVQQPSIVVNSQPPKQRNDNQPTVNVGHAEEQSPRLAILLPVMIILAWLVILVCIGAVVCCKRRNSRESSQLRAMYGAAYGVRPTAYESKRKESTYEDHLERAARLSGQPALSGQQAGKVSLYGSYWNLEPLSNHSPARLSTQERQSPPSFVNNGYTNQTTRYTYAGHY
Protein: Neurofibromin 1b (Neurofibromin isoform X1) (E7FFY1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- GTPase NRas
- HRas proto-oncogene, GTPase a.
- small monomeric GTPase
- small monomeric GTPase
- RAS-related 2
- Muscle RAS oncogene homolog
- RAS-related
- Ras-related protein M-Ras
- Neurofibromin 1a.
- Oligodendrocyte myelin glycoprotein a.
Sequence:
MAAQKPVEWVQAVISRFDEQLPVKVGVQNTHTKISTEHNKECLINISRYKFSLVISGLTNILKNVNNMRIFGDTAERNLYLSQLIILDTLEKCLAGQPKDSMRLDETMLVKQLLPEICHFIHTYREGNQHAAELRSSACGVLFSLSCSNFNAVFSRISTRLQELTVCSEDTVDVHDIELIQYINVDGCKLKRLLQETVFKFKALKKPAQLSVIFNLEKAFWNWVENYPDEFTRLYQRPQTDMADCAEKLFDLVDSFAESTKRKAAVWPLQIILLILCPDITQDMSRDAAEDAKDNKKLFLENLRKALTGHGGSKQLTESAAIACVKLCKASTYISWEDHSVIFLLVQSIVMDLKGLLFNPVKPFSRGAGSQSADLDLMIDCFVSCFRINPHNNQQFKVCLASSSPSTFHFVLVNSLHRIITNSPLDWWPKIDTVYCYSGELRLMFAETLGRVVQGCSHTTLRLTPSLTFKEKMSSLKFKEKTTDLDTRSLKYLLLALVKLIHADPKLMLHNPGKQGLEVHSSTAELITGLVQLVPLANMGEISQEAMEALLVLHQPESIELWNPDAPMETFWDISSQVLYFICKNLFGHPLVSSTEILKWLREILICRNKFLLRNKDRATVGSNIATCRQAQTKLEVCLYMFLWSPDMEAVLVAMSCFRYLCEEAEIRCGVEDIPVQSLLPNYNTFMEFASVSNMMVTGRSALQKRVMALLRKIELPTPGNTEAWEDTHAKWEHATKLILSHPKTKLEDGQEWINMTGFLCALGGVCLQQRHVSALATYSPPMGTLNDRKGSMVSMSSCEGSPETPLGRFLDRLLSLMVCSHEKGHQIRTNVKDLVGLELSPVLYPMLFNKLKNSISRFFDAQGPVPINETNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRILGNMVHAIQIKTKLCQLVEVMMERRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDEGQPVVGRKRGMSRRLASLRHCTILAMSNLLSANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETALADRFERLVELVTMMGDQGELPIAMALASVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLEPLLRSVIAGTEWHMLSFEVDPTRLENGENLEENQRNLLRMTERFFKAIISSSGEFPPQLRSVCHCLFQATCHSLLSKASVKDRKEVRKAVVSQRFPQNSIGAVGSAMFLRFVNPAIVSPYEAGILDKKPQPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPASDSLNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLHIFYQAGTSKNGNPVFYYVTRRFKTGQINGDLLIYHVLLTLKPYYAKPYELVVDLTHAGPSNRFKTDFLSKWFVVFPGFAYENVAAIYIYNCNTWVREYTKYHERLLTGLKGSKKLLFIDSPARLAEHVEPEQQKLPAATLALEEDLKVFHNALKLAHRDTKVSIKVGSTAVQVTSAERTRVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECESIVHSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISQTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLLNLVRFCKHSDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIIRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTLLVATGPLSLRASTHGLVINIIHSLCTCSQLSFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALSSLETVTEALLEIMEACMRDIPGCKWLDQWTDLAQKFAFQYNPSLQPRALVVFGCISKRVTHTQMKQIIRILSKASLLLSIDRGLESCLKGPDNCNSQVLIEATVIALTKLQPLLNKDSAMHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRVFNDKSPEEVFMEIRQPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGFRHPSPTTVARTIRILHMLLALVGKHQNCDKFEVNTQSVAYLAALLPVSEEVRSRCSLKHRKLLLFSDVTMENVQMDPYSVHHEDPSGRTLRENELWASPKVSERYLVAHFPIMGQISPRTRKSMSLDMGQPSQVNTKKLLGTRKSFDLLLSDSKAPKRPEIETGITTPPKMRRVAENEYEIETPRISHHHLRKVSVSESNVLLNEEVLTDPKIQALLLTVLATQVKNTSDEFEQRILYEFLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPHLLNPVHGIVQSVVYHEESPPQYQPSYLQTFGFNGLWRFAGPFSKQTQFPDYAELIVKFLDALIDTYLPGIDEETSEEGLRTPTSPYPPPVQSQLSITANLNLSNSMTSLATSQHAPGMDKEKVDLSPTTGLAAGGRTRHGSASQVQKQRSTGSFKRPSIKKIV
Protein: Eye-enriched kainate receptor, isoform B (Q0KIF2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}.
Interaction partners:
Sequence:
MLIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWCMNKQKRPALTRTCSKCTIPKGQRINKL
Protein: Myocardin (Q8R5I7)
Organism: Rattus norvegicus (Rat)
Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes (By similarity). Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12392995, ECO:0000269|PubMed:19237536}.
Interaction partners:
- Serum response factor
- Calponin
- T-box transcription factor TBX5
- Homeobox protein Nkx-2.5
- Myosin-10
- KLF transcription factor 4
- Transgelin
- Myocyte-specific enhancer factor 2C
- Transcription factor GATA-4
- Heart- and neural crest derivatives-expressed protein 2
Sequence:
MTLLGSEHSLLIRRKFRSVLQLRLQQRRTQEQLANQGLIPPLKSPTEFHDPRKKLDSAKTEDSLRRKVRNRSDRASLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPMDSSVKEAIKGTEVSLSKAADAFAFEDDSSRDGLSPDQARSEDPQGSGGSTPDIKSTEAPLAGPLDTIQDLTPGSESDKNDTASQLSNQSDSGKQVLGPLSTPIPVHTAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQQQQQQQQQQQQQQRFSYPGMHQAHLKEPNEQMTRNPNSSSTPLNNTPLSPVKNSLSGQTGVSSLKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALVDRLRPFQDCAGNPVPNFGDITTVTFPVTPNTLPSYQSSPSGFYHFGSTSSSPPISPASSDLSAAGSLPDTFTDASPGFGLHASPVPACTDESLLSSLNGGSGPSEPDGLDSEKDKMLVEKQKVINQLTWKLRQEQRQVEELRMQLQKQKSGCNDQKPLPFLATTIKQEDVSSCPFAAQQASGKGQGHSSDSPPPACETAQLLPHCVESSGQTHVLSSTFLSPQCSPQHSPLGTLKSPQHISLPPSPNNHYFLASSSGAQRENHGVSSPNSSQGCAQMTGLQSSDKVGPTFSIPSPTFPKSSPTVPEITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKIPKIPGSSCSPTTILPKSSASFEQASSGGQISFDHYATDSEEHLEVLLNSHSPIGKVSDVTLLKIGSEEPPFDGIMDGFPGKAAEDLFSAHELLPGPLSPMHTQLSPPSVDSSGLQLSFTESPWETMEWLDLTPPSSTPGFSNLTSSGPSIFNIDFLDVTDLNLNSPMDLHLQQW
Protein: ADAM metallopeptidase domain 9 (ADAM9 protein) (A0AVL1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNGQMAKIKQTLLDSRGVFLDMFLQ
Protein: Protein unc-93 homolog B1 (Unc-93B1) (Q8VCW4)
Organism: Mus musculus (Mouse)
Function: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Colocalizes with LAMP5 in large endosomal intracellular vesicles (By similarity). Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides. {ECO:0000250}.
Interaction partners:
- Toll-like receptor 3
- Toll-like receptor 7
- Toll-like receptor 8
- Toll-like receptor 9
- Toll-like receptor 13
- Protein canopy homolog 3
- Myeloid differentiation primary response protein MyD88
- Syntenin-2
- Endoplasmin
- Serine/threonine-protein kinase TBK1
Sequence:
MEVEPPLYPVAGAAGPQGDEDRHGVPDGPEAPLDELVGAYPNYNEEEEERRYYRRKRLGVVKNVLAASTGVTLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMSQKYYEYSHYKEQDEQGPQQRPPRGSHAPYLLVFQAIFYSFFHLSFACAQLPMIYFLNNYLYDLNHTLINVQSCGTKSQGILNGFNKTVLRTLPRSKNLIVVESVLMAVAFLAMLMVLGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDFRLRHLVPFFIYSGFEVLFACTGFALGYGVCSMGLERLAYLLIAYSLGASASSVLGLLGLWLPRSVPLVAGAGLHLLLTLSLFFWAPAPRVLQHSWIFYFVAALWGVGSALNKTGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFVVYLGSSLPMKAKLAVLLVTLVAAAASYLWMEQKLQQGLVPRQPRIPKPQHKVRGYRYLEEDNSDESDMEGEQGQGDCAEDEAPQAGPLGAEPAGPCRKPCPYEQALGGDGPEEQ
Protein: Olfactory receptor 2L13 (Olfactory receptor 2L14) (Q8N349)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Olfactory receptor 2C1
Sequence:
MEKWNHTSNDFILLGLLPPNQTGIFLLCLIILIFFLASVGNSAMIHLIHVDPRLHTPMYFLLSQLSLMDLMYISTTVPKMAYNFLSGQKGISFLGCGVQSFFFLTMACSEGLLLTSMAYDRYLAICHSLYYPIRMSKMMCVKMIGGSWTLGSINSLAHTVFALHIPYCRSRAIDHFFCDVPAMLLLACTDTWVYEYMVFVSTSLFLLFPFIGITSSCGRVLFAVYHMHSKEGRKKAFTTISTHLTVVIFYYAPFVYTYLRPRNLRSPAEDKILAVFYTILTPMLNPIIYSLRNKEVLGAMRRVFGIFSFLKE
Protein: Ryanodine receptor 3 (O35209)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
KSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVRED
Protein: Enhanced ethylene response protein 5 (Nuclear mRNA export protein THP1) (AtTHP1) (Q8GWE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of ethylene response. Probable TREX-2 component required for nuclear RNA export. The TREX-2 complex (transcription and export complex 2) functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Subcellular location: Nucleus {ECO:0000269|PubMed:19843313}.
Interaction partners:
- SAC3 family protein B
- SAC3 family protein A
- SAC3 family protein C
- Transcription and mRNA export factor ENY2
- Protein DSS1 HOMOLOG ON CHROMOSOME V
- Protein DELETION OF SUV3 SUPPRESSOR 1
- Nuclear pore complex protein NUP1
- Phosphoinositide phosphatase SAC3
- THO complex subunit 7B
- Transcription initiation factor TFIID subunit 12b
Sequence:
MAYVSMGEAHRRITEYLNRFCDAVSYQDSSTLCRLLSFSSNSPPLLSLADALNVFQDSSSLIRQSDRFSEYGEILAHVFRSLQSYRVGNLVEAYLAFDKFANAFVQEFRNWESAWALEALYVVCYEIRVLAEKADKDLTSNGKSPEKLKAAGSLLMKVFGVLAGKGPKRVGALYVTCQLFKTYFKLGTVNLCRSVIRSIETARIFDFEEFPRRDKVTYMYYTGRLEVFNENFPAADTKLSYALQNCNPKRERNIRMILKYLVPVKLSLGIIPKDELLRNYNLHEYTKIVQALRKGDLRLLRHALQEHEDRFLRSGVYLVLEKLELQVYQRLMKKIYINQKLSDPARAHQLKLEGIAKALRWLDMDMDLDEVECIMTILIYKNLVKGYLAHKSKVVVLSKQDPFPKLNGKPVSS
Protein: Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial (IDH-I) (Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1) (Q8LFC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Performs an essential role in the oxidative function of the citric acid cycle.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022}.
Interaction partners:
- Peroxisomal isocitrate dehydrogenase
- Isocitrate dehydrogenase, chloroplastic/mitochondrial
- Cytosolic isocitrate dehydrogenase
- Isocitrate dehydrogenase catalytic subunit 5, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase catalytic subunit 6, mitochondrial
- Aconitate hydratase 1
- 2-oxoglutarate dehydrogenase, mitochondrial
- Aconitate hydratase 3, mitochondrial
- Aconitate hydratase 2, mitochondrial
Sequence:
MSRRSLTLLKNLARNANGSGIQTRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSRVPPEVMESIRKNKVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPSITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGKDKIVLENKANPVALLLSSAMMLRHLQFPSFADRLETAVKKVIAEGKCRTKDLGGTSTTQEVVDAVIAKLD
Protein: Tetraspanin-5 (Tspan-5) (Transmembrane 4 superfamily member 9) (Q68VK5)
Organism: Rattus norvegicus (Rat)
Function: Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P62079}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 10
- Glutamate-rich 3
Sequence:
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
Protein: AP-1 complex subunit gamma (Q86V28)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MDRRIENRMGTPAHRRRVVHTHRHTRNRLSCPWPPPFTSPTLTPGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLPVESWQ
Protein: Zinc finger protein 554 (Q86TJ5)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MVTCAHLGRRARLPAAQPSACPGTCFSQEERMAAGYLPRWSQELVTFEDVSMDFSQEEWELLEPAQKNLYREVMLENYRNVVSLEALKNQCTDVGIKEGPLSPAQTSQVTSLSSWTGYLLFQPVASSHLEQREALWIEEKGTPQASCSDWMTVLRNQDSTYKKVALQEEPASGINMIKLIREDGGWKQLEDSHEDPQGLLSQKASLHVVAVPQEKATAWHGFGENGNLSPALVLSQGSSKGNHLCGSELDITSLASDSVLNHHQLGYADRRPCESNECGNAIRQNSHFIQHGGKMFVYLENGQSLNHGMALTIHNKINTAEKPFECHQCGKVFNRRHSLSEHQRIHTGEKPYECQECGRAFTHSSTLTRHLRTHTGEKPYGCGECGKAFNRISSLTQHQRIHTGEKPYKCEDCGKSFCQSSYLILHKRTHTGEKPYECSECGKAFSDRSSLNQHERTHTGENPYECKQCGRAFSQRSSLVRHERTHTGEKPYRCQECGKAFSQSSSLVTHQKTHSSQKTYKIIDCGKAFYQNRHLIGY
Protein: Proton pump-interactor BIP131 (BRI1-interacting protein 131) (Q6ZBF6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May regulate plasma membrane ATPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O23144}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEATGAEATLSQVTAVDGEDNLFQDKESRATAKERGEAAVFGLENIVTANGATSAADLAPPKDVVDEWPEPKQTHTFFFVRICSYEDPSLKAKLEQADKECQKKIQARSHIFEALRTKRSERSNIISELKPLAAENKQYNEVVSGKLKEIEPLQKSLGKFRSENNAMRAQGAGLCSSIEELDQLIKSLNDRISHESISLDEEKRLVKEIKQLNGTRSKVIENAAKRAKMQDTVVERGTIHDQVKQIGVGIDEVKRDRQAVRDKIKVLEDQIHAVDGEIAALQDDLTAATARKDKAFEALNELRKTRDLNNTSFHQYRTISNSVRDLSARGEVEAVQQLCQNEVEKFMAQWCSSKSFREDYEKRILVSLNSRQLSRDGRMRNPDEKPIVLETQVAPPAEQEPAPLKKPAKQAKEAPAPRADVTPKDEIRAKAPAKAAKAKQPLDIDDIPDVHDDEPPKEKTKPKVDEAKLKEMKRQEEIEKNKLALERKKKQAEKQAMKAAARAEKEAEKKLKEKEKKARKRSATAGGAESEEAAESDAKSDEAEAQEEEPAAPVTIKKNARHRSTVTKTKTPLPKAVLKRKKSQAFWSWGAPMAALAAALVALLGALVYYQYYYLPASTSN