wanglab/gogpt-training-data huggingface dataset:
Protein: LD36341p (SMG5 protein) (Smg5 nonsense mediated mRNA decay factor, isoform A) (Smg5 nonsense mediated mRNA decay factor, isoform B) (Smg5 nonsense mediated mRNA decay factor, isoform C) (Q9V414)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- FI21285p1
- GH14566p
- Regulator of nonsense transcripts 1 homolog
- Serine/threonine-protein kinase Smg1
- RE04053p
- 5'-3' exoribonuclease 1
- Eukaryotic translation release factor 3, isoform A
- Eukaryotic translation initiation factor 4G1, isoform B
- Nuclear cap-binding protein subunit 1
- Polyadenylate-binding protein
Sequence:
MEVTFSSGGSSNASSECAIDGGTNRCRGLEPNNGTCILSQEVKDLYRSLYTASKQLDDAKRNVQSVGQLFQHEIEEKRSLLVQLCKQIIFKDYQSVGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYLIDFSIISDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRIDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLNKLFAKHTEYLERMDPEKLDFNIEDFFARFYLIVDIFFFDKEVPDFNALCHCVLIDLRKILCSQQLRVPEPSIFKIVSILFFCLSKLKMINSPKVYSLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGECERKDKKLMPRPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKSKRRGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGEERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSFEVLQLNFKSAEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINPNIVIDCLHNEPTIRALKMLFDWLRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVELFDVRANVPLTEDFAFKNFDIFQSTQITLDWETIIRERVTPQEESILRIFKMVDFGFFICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRTRRYSDRKNGIVRKSYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATGTSVAGGTSASTTTNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSPFVVVDSKALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKRSENVRHVIRWLEQEFKQGNRHLRAQRDNESQPLSLLKISRKMDRDASVFLQIAQFCNHLVANHADPHVSELQKSVVTYLSGDNLHEKNRQQQNFSYTGILDSIPVRYAQIQSFYAKFKANKK
Protein: Neurotransmitter-gated ion-channel transmembrane domain-containing protein (D7SFP2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLVIVSWVSFWIDRTAVPARVTLGVTTLLTMTTQSSGINAKLPPVAYIKAIDVWIGACMTFIFCALLEFAWVTYIANKQDANKRARTEREKAELPFLQNSHNDVWVPREVAEQEREVMTVRMNRRQTNSVWKWIKTKTEWNDKSKRADLISRVMFPVLFLTFNISYWTHYGQYGVAIST
Protein: Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1) (P00452)
Organism: Escherichia coli (strain K12)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
Interaction partners:
- Ribonucleoside-diphosphate reductase 1 subunit beta
- Ribonucleoside-diphosphate reductase 2 subunit beta
- Uncharacterized ferredoxin-like protein YfaE
- Glutaredoxin 1
- Nucleoside diphosphate kinase
- UPF0301 protein YqgE
- Ribonucleoside-diphosphate reductase 2 subunit alpha
- Thymidylate kinase
- Cytidylate kinase
- Adenylate kinase
Sequence:
MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI
Protein: Ran binding protein 7 (Q7KIF8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNLINSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWPQVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQSEQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVPDSSHLDDDERTEFPYWKTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRVLTDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDYATPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQHLATTFSQVLESEEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHNITDFYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNPNRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQIDSVIHMFVELALSRLTREVQSSELRTMCLQVVIAALYYNPQLLLSILDKMSQQNNDSISAHFIKQWLHDTDCFLGIHDCKLCVLGLCTLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQEEEEDEEEEDGDDCEEALSSDEDDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQGGFAFPQTAVPTSFKFGS
Protein: Mitochondrial distribution and morphology protein 35 (O60200)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17095012, ECO:0000269|PubMed:20622808, ECO:0000269|PubMed:20657548, ECO:0000269|PubMed:22984289}.
Interaction partners:
- Protein UPS1, mitochondrial
- Protein UPS2, mitochondrial
- Protein UPS3, mitochondrial
- Mitochondrial intermembrane space cysteine motif-containing protein MIX14C motif protein of 14 kDa)
- Cardiolipin synthase
- Phosphatidate cytidylyltransferase, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylglycerophosphatase GEP4, mitochondrial
- Cytochrome c oxidase copper chaperone
- Mitochondrial intermembrane space import and assembly protein 40
Sequence:
MGNIMSASFAPECTDLKTKYDSCFNEWYSEKFLKGKSVENECSKQWYAYTTCVNAALVKQGIKPALDEAREEAPFENGGKLKEVDK
Protein: Importin subunit alpha-1 (J3QLL0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCS
Protein: Tumor necrosis factor receptor superfamily member 10b (B8YBG7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLQAFLLLSFFVPVTAKLAQDRPADLQRLKQSPLECPAGQYLSKEDGSCKACIDGENYTSGPNVLPSCLSCRVCKEDKVIKSRCVKARNTECECKPGSFEDKDSTEICQTCSNCTDGEDEVIPCTPKANRKCVPKNTQIPQHNLGLLIGLLASVISVVLFVAVIWKTKAWESVCLFMARVYPGCEQDHENTVGLSLLDAQTSRKTNGSHHNTEPDRTQSSPLGRKLLVLANGNNPADALKLIFERCSTEVPFNSWDRLMRHMGLTDNQIQMVRAETQVPCEVLYQMLLKWLYQTGLGASINHLLGALEAVGERCALEEIEDYAVKSGKFVYQNTTA
Protein: Voltage-dependent T-type calcium channel subunit alpha (Q5SUG4)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
- Calmodulin-like protein 4
- Voltage-dependent T-type calcium channel subunit alpha-1H
- Calmodulin-1
- Voltage-dependent T-type calcium channel subunit alpha
- Voltage-dependent calcium channel subunit alpha-2/delta-2
- Short transient receptor potential channel 1
- Calmodulin-like protein 3
- Calmodulin-4
- Calmodulin 5
- Estrogen receptor beta
Sequence:
MDEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAVGVRAGLLSSPVARGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRWLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPEMLKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHEMPDSDSEAVYEFTQDAQHSDLRDPHRRRRPSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDTSGQLSCIQLPVNSQGGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHSELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGKSASGRLARTLRADDPPLDGDDGDDEGNLSKGERLRAWVRARLPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGPRPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTDLDP
Protein: 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (cAMP-specific phosphodiesterase 4D) (P14270)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Subcellular location: Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Deoxycytidine kinase
- Adenosine kinase
- Adenine phosphoribosyltransferase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- A-kinase anchor protein 7 isoforms delta and gamma
- Adenylosuccinate lyase
Sequence:
MEAEGSSVPARAGSHEGSDSSGGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEDGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPQTGVADDCCPDT
Protein: CHp/Wrch Rho-like protein homolog (Q19739)
Organism: Caenorhabditis elegans
Interaction partners:
- Serine/threonine-protein kinase max-2
- Serine/threonine-protein kinase pak-1
- Major sperm protein
- Serine/threonine-protein kinase pak-2
- BPTI/Kunitz inhibitor domain-containing protein
- Unconventional myosin-IXa-like
- Calponin-homology
- ShKT domain-containing protein
- Partitioning defective protein 6
- Intersectin-1
Sequence:
MAKEEDEKCLKCIFVGNAAVGKTSMIVSYTTNVYPHNYVPTAFDNFSVVVLVDKKPIRLQLHDTAGQSSFDTLRPLCYTDADVFVIVYSVVDLQSFEDVSHHWYPEVTKRNPGTKLILVGTQADQRWQVRGNTVTQLRGKALADRLGAEFFECSALTQHNLKQMFDAAILAGLEGKKNREKRSNFYTKSSKIKERVARFITRTRNLI
Protein: Speedy protein C (Rapid inducer of G2/M progression in oocytes C) (RINGO C) (hSpy/Ringo C) (Q5MJ68)
Organism: Homo sapiens (Human)
Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20605920}. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.
Interaction partners:
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 2
- M-phase inducer phosphatase 3
- Nuclear transcription factor Y subunit beta
- Nuclear transcription factor Y subunit alpha
- DNA polymerase epsilon subunit 3
Sequence:
MSDSQDPTTSPVVTTQVELGGCSRQGGGNGFLRFRQHQEVQAFLSLLEDSFVQEFLSKDPCFQISDKYLLAMVLVYFQRAHLKLSEYTHSSLFLALYLANDMEEDLEGPKCEIFPWALGKDWCLRVGKFLHQRDKLWARMGFRAVVSRQCCEEVMAKEPFHWAWTRDRRPHHGGVQRVCPQVPVRLPRGPGLSPPHCSPCGLPQHCSSHLLKPVSSKCPSLTSECHRPPSQNYLSRVKNAWGGDFLIVLPPQMQLEPGTYSLRIFPKPPARPGH
Protein: Mitochondrial inner membrane protein OXA1L (Oxidase assembly 1-like protein) (OXA1-like protein) (Q8BGA9)
Organism: Mus musculus (Mouse)
Function: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q15070}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q15070}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Large ribosomal subunit protein mL45
- Small ribosomal subunit protein mS37
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein bL12m
Sequence:
MARNLVCGRWQLLRLLRPQRSYHSVAVSLRPLAAELLAARRGNGRPPCALLAVFTPRCISTSATLFAEAQVQAPPVIPATSIPAAVPEVASGGAADVVQCATEPSFTELGLGSYTPVGLIQNLLEYIHVDLGLPWWGAIATCTVLARCLVFPLIVKGQREAAKIHNHMPEMQKFSARIREAKLAGDQAEFYKATIEMTRYQKKHDIKLLRPLILPLTQAPVFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYVLPLVVTATMWCVLELGAETGVQSNDLQFMRNIIRVMPLVVLPVTIHFPSAVFMYWLSSNVFSLCQVACLRIPAVRTVLKIPQRVVHDPDKLPPREGFLKSFKKGWKNAEIAQQLREREQRMQKHLDLAARGPLRQTFTHNPLLQHDPSHPPKAPNSNNSSIKANAKKPWQDTLG
Protein: Large ribosomal subunit protein uL6 (50S ribosomal protein L6) (BL10) (P46898)
Organism: Bacillus subtilis (strain 168)
Function: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Interaction partners:
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein bL27
- Large ribosomal subunit protein bL36
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS2
Sequence:
MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEIKVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGNKLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKGKGIRYEGEVVRRKEGKSAK
Protein: E3 ubiquitin-protein ligase siah-1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Q965X6)
Organism: Caenorhabditis elegans
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Interaction partners:
- Beta-catenin/armadillo-related protein 1
- Beta-catenin-like protein hmp-2
- Armadillo repeat-containing protein wrm-1
- Ubiquitin-conjugating enzyme E2 13
- Ubiquitin-conjugating enzyme E2 variant 1
- Ubiquitin carboxyl-terminal hydrolase
- Glyceraldehyde-3-phosphate dehydrogenase 4
- Glyceraldehyde-3-phosphate dehydrogenase 1
- USP domain-containing protein
Sequence:
MSNRNGGGGGGDYQDVIESLRRTQLIFEEDDNNSSDSAPQANHLSRHQTSNSLVEDMVNHSNGNPPPVPPGITQQQCQIGLTPRMSASPPSAVSTISGTAVLGKTMARVQSNPPGSIPHNTTTTAQGIQSVAPHIPIGGGGATDDSSAEILSVFECPVCLEYMLPPYMQCSSGHLVCSNCRPKLQCCPTCRGPTPSVRNLGLEKIANTVRFPCKFSTSGCPLNFHHADKTEHEELCEFRPYCCPCPGASCKWQGGLSDVMEHLKKIHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFDYNFMLVLEKQEKYDPAQPTQMFYAVVQLIGSKKEADNFVYRLELSASRRRMSWEATPRSIHEGVVVAIQQSDCLAFDSNAAQLFAENGNLGINVTISRIDTPQRRHPNELENSDLEYD
Protein: Zinc finger CCCH domain-containing protein 21 (AtC3H21) (Q9SK74)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Developmentally-regulated G-protein 3
- Developmentally-regulated G-protein 1
- Developmentally-regulated G-protein 2
- Probable transcription factor At1g61730
- Zinc finger CCCH domain-containing protein 53
- Large ribosomal subunit protein uL18y
- Zinc finger CCCH domain-containing protein 5
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL23y
Sequence:
MPPKQQPKADLAKKQKQVEDKTFGLKNKNKSKNVQKYVQSLKQSVQPKPDATKAAAKKKKEEEKAREQELNELFKVAISQPKVPVGVDPKSILCEFFKAGQCQKGFKCKFSHDLNIQRKGEKIDIYSDTRDEDGDMDEWDQETLEKVVESKKNEYNQNKPTDIVCKYFLDAVEKKQYGWFWSCPNGGKECHYRHALPPGYVLKSQMKALLEEESSKKLAVEDEIENERAKLQTATQMTPALFMEWKRKKIAERDAGLAASQAERAKNDRMSGRELFLSNASLFVDDAEACEEYEREREQEETEQKAKNKEAEAGTSKSSGDAEQSSKEVNEEEEDDDDDDDDLDMDELDELEASLSKTSIQIREPNDEGSS
Protein: 14-3-3-like protein 2 (Q20655)
Organism: Caenorhabditis elegans
Function: Required for extension of lifespan by sir-2.1. Required to modulate lifespan, in concert with hcf-1, acting redundantly with 14-3-3-like protein par-5. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16777605, ECO:0000305|PubMed:21531333}. Nucleus {ECO:0000269|PubMed:16777605}.
Interaction partners:
- Forkhead box protein O
- NAD-dependent protein deacetylase sir-2.1
- Raf homolog serine/threonine-protein kinase
- Beta-catenin-like protein hmp-2
- Importin N-terminal domain-containing protein
- Yes-associated protein homolog 1
- mitogen-activated protein kinase kinase
- Dual specificity mitogen-activated protein kinase kinase mek-2
- Kinase suppressor of Ras B
- Kinase suppressor of Ras A
Sequence:
MSDGKEELVNRAKLAEQAERYDDMAASMKKVTELGAELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSEKKQQMAKEYREKVEKELRDICQDVLNLLDKFLIPKAGAAESKVFYLKMKGDYYRYLAEVASGDDRNSVVEKSQQSYQEAFDIAKDKMQPTHPIRLGLALNFSVFFYEILNAPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDAATDDTDANETEGGN
Protein: Aminoglycoside N(6')-acetyltransferase type 1 (EC 2.3.1.82) (AAC(6')-Iy) (Aminoglycoside resistance protein) (Q9R381)
Organism: Salmonella enteritidis
Function: Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. Able to acetylate eukaryotic histone proteins.
Interaction partners:
Sequence:
MDIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC
Protein: Sphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2) (Spinster homolog 2) (Spns2) (Q91VM4)
Organism: Mus musculus (Mouse)
Function: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking. S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking. Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph. Also required for the egress of immature B-cells from the bone marrow. In contrast, it does not mediate S1P release from red blood cells. Involved in auditory function: S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea. In addition to export, also able to mediate S1P import.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:A2SWM2}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:A2SWM2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sphingosine-1-phosphate transporter MFSD2B
- Sphingosine 1-phosphate receptor 2
- Sphingosine kinase 1
- Sphingosine kinase 2
- Sphingosine 1-phosphate receptor 1
- Sphingosine 1-phosphate receptor 3
- Sphingosine-1-phosphate lyase 1
- Sphingosine 1-phosphate receptor 5
Sequence:
MMCLECASAAAGGAEEEEADAERRRRRRGAQPGAGGSACCGARGVGGAGVVSADEEVQTLSGSVRRVPSGLPSIPSTPGCAAAAKGPSAPQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFLSDRAKAEQQVNQLVMPPASVKV
Protein: Probable methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS) (O14000)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:16823372}.
Interaction partners:
- tRNA-aminoacylation cofactor arc1
- Probable methionine--tRNA ligase, cytoplasmic
- Putative methionyl-tRNA formyltransferase
- Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Probable arginine--tRNA ligase, cytoplasmic
- Putative leucine--tRNA ligase, cytoplasmic
- Putative leucine--tRNA ligase, mitochondrial
- Tyrosine--tRNA ligase, cytoplasmic
- Exportin-T
- Asparagine--tRNA ligase, mitochondrial
Sequence:
MLRKGICRLIHQVSESSKKPYFLTTPIFYVNAAPHLGHLYSLVLTDAIARFQNLKPDVSVISSTGTDEHGLKVQTVAQTEGVSPLQLCDRNSKRFADLAVAANTKFTHFIRTTNPKHQASVQEFWKTIQKAGMISFERHEGWYCVSDETFYPESAIQKVVDPATKQEKRVSMETGKEVQWSSEMNYHFLLSKFQSRLIEHYNKNPNFVQPSIFHTQVLEELKTGISDLSISRPKQRLSWGIPVPGNSQQTIYVWLDALINYISVIGYPWLNEKSSLSAGWPANMHVIGKDIIRFHCIYWPAFLMAAGLPLPEKILVHSHWTMNKVKMSKSLGNVVDPFWLIEKYGVDTIRYYLLKRGRLTSDSNFDIEELEKDEEHDLRRSLGVLLSRLQSKKLFISNEIQKQWHKKDDFTEYEDIVHELIELPVVCAQSIDGGCVYEVINLVQSVLRRVTKLFQLKEPWKLSDDSQEKIDTLMLVAHSLRISGILLQPIMPTKSTELLDQLGIPKNQRSLQNATNVFEPTEFTFHSGNNSHLFDKRTQ