wanglab/gogpt-training-data huggingface dataset:
Protein: Probable disease resistance protein At5g63020 (pNd11) (Q8RXS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable disease resistance protein.
Interaction partners:
- F-box/kelch-repeat protein SKIP6
- Disease resistance protein
- LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.2
- Probable disease resistance protein At4g19060
Sequence:
MGGCVSVSISCDQLTKNVCSCLNRNGDYIHGLEENLTALQRALEQIEQRREDLLRKILSEERRGLQRLSVVQGWVSKVEAIVPRVNELVRMRSVQVQRLCLCGFCSKNLVSSYRYGKRVMKMIEEVEVLRYQGDFAVVAERVDAARVEERPTRPMVAMDPMLESAWNRLMEDEIGILGLHGMGGVGKTTLLSHINNRFSRVGGEFDIVIWIVVSKELQIQRIQDEIWEKLRSDNEKWKQKTEDIKASNIYNVLKHKRFVLLLDDIWSKVDLTEVGVPFPSRENGCKIVFTTRLKEICGRMGVDSDMEVRCLAPDDAWDLFTKKVGEITLGSHPEIPTVARTVAKKCRGLPLALNVIGETMAYKRTVQEWRSAIDVLTSSAAEFSGMEDEILPILKYSYDNLKSEQLKLCFQYCALFPEDHNIEKNDLVDYWIGEGFIDRNKGKAENQGYEIIGILVRSCLLMEENQETVKMHDVVREMALWIASDFGKQKENFIVQAGLQSRNIPEIEKWKVARRVSLMFNNIESIRDAPESPQLITLLLRKNFLGHISSSFFRLMPMLVVLDLSMNRDLRHLPNEISECVSLQYLSLSRTRIRIWPAGLVELRKLLYLNLEYTRMVESICGISGLTSLKVLRLFVSGFPEDPCVLNELQLLENLQTLTITLGLASILEQFLSNQRLASCTRALRIENLNPQSSVISFVATMDSLQELHFADSDIWEIKVKRNETVLPLHIPTTTTFFPNLSQVSLEFCTRLRDLTWLIFAPNLTVLRVISASDLKEVINKEKAEQQNLIPFQELKELRLENVQMLKHIHRGPLPFPCLQKILVNGCSELRKLPLNFTSVPRGDLVIEAHKKWIEILEWEDEATKARFLPTLKAFPENIDADGYEISF
Protein: Uncharacterized protein (F4JKZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Lipase class 3 family protein
- Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein
- F17A9.5 protein
- At2g47310
- U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Sequence:
MIALSLSVSLTSLPFSFAFSSTPCKSRASPPRSTVSLSSSRRRQDRRRSIEAMSQVMELEDESDFEKLLSSDNRISITGFGSLLSERSARSTFPDLENFRIAKLQGFRRVFAHSAPIFFERGIANPETKEISSLSVEPCEGESLVVTVFEIKSSEIPAFIGRELEFRFLAVVPETLEGKPYTNSAVLCGRYSDEEFFQIRCKGNKGIYFQHYGRFKIDKIWRDDILPCRLYLRHCVLAAKNLGDEAYNNFLDHTFLGDRKTTIREYLSSTGSGIMEEEPPEALKSRYGG
Protein: Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Q59RQ6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- dihydrolipoyllysine-residue succinyltransferase
- Pyruvate dehydrogenase E1 component subunit beta
- Acetyltransferase component of pyruvate dehydrogenase complex
- Glycine cleavage system H protein
- 2-oxoglutarate dehydrogenase, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha
- Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex
- Aminomethyltransferase
- Succinate--CoA ligase subunit beta, mitochondrial
- Glycine cleavage system P protein
Sequence:
MLRSFKSIPANGKLAQFVRYASTKKYDVVVIGGGPGGYVAAIKAAQLGLNTACIEKRGALGGTCLNVGCIPSKSLLNNSHLLHQIQHEAKERGISIQGEVGVDFPKLMAAKEKAVKQLTGGIEMLFKKNKVDYLKGAGSFVNEKTVKVTPIDGSEAQEVEADHIIVATGSEPTPFPGIEIDEERIVTSTGILSLKEVPERLAIIGGGIIGLEMASVYARLGSKVTVIEFQNAIGAGMDAEVAKQSQKLLAKQGLDFKLGTKVVKGERDGEVVKIEVEDVKSGKKSDLEADVLLVAIGRRPFTEGLNFEAIGLEKDNKGRLIIDDQFKTKHDHIRVIGDVTFGPMLAHKAEEEGIAAAEYIKKGHGHVNYANIPSVMYTHPEVAWVGLNEEQLKEQGIKYKVGKFPFIANSRAKTNMDTDGFVKFIADAETQRVLGVHIIGPNAGEMIAEAGLALEYGASTEDISRTCHAHPTLSEAFKEAALATFDKPINF
Protein: 26S proteasome non-ATPase regulatory subunit 13 homolog B (26S proteasome regulatory subunit RPN9b) (AtRNP9b) (26S proteasome regulatory subunit S11 homolog B) (Q8GYA6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome regulatory subunit 7 homolog B
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit-like protein
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 7 homolog A
- Proteasome subunit beta type-6
- Proteasome subunit beta type-1
- 26S proteasome regulatory subunit 6A homolog B
- 26S proteasome regulatory subunit RPN13
Sequence:
MAALQYLESQKNAHPELGEWYNSLADLYQKKLWHQLTLKLEQFIALSVFQAGDALIQLYNNFITDFETRINLLKLAHFAVVVSRQYPEKEAAVSYLEGVIEKLKATKESRINEPISYIETQIALFKLEQGDQKECKKILDDGKSLLDSMTDIDPSVYANFFWVSSQYHKVRQEFSEFYKNALLYLAYTSVDSLSESFKLDLAFDLSLSALLGENIYNFGELLAHPILKSLLGTNVEWLYHILQAFNHGDLVQYQELCRVHNASLSAQPALVENEKKLLEKINILCLIEIIFSRPAEDRTIPLSVIAERTKLSIEDVEHLLMKSLSVHLIEGILDQVNGTVYVSWAQPRVLGIPQIKSLRDQLDSWVDKVHTTLLSVEAETPDLVAA
Protein: Phospholipase C D (PLC-D) (EC 3.1.4.3) (P9WIA9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in virulence. Induces cytotoxic effects on mouse macrophage cell lines, via direct or indirect enzymatic hydrolysis of cell membrane phospholipids. Hydrolyzes phosphatidylcholine. Does not have hemolytic activity.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:20736081}. Note=Remains associated with the cell. {ECO:0000269|PubMed:20736081}.
Interaction partners:
- Phospholipase C B
- Phospholipase C C
- Phospholipase C A
- Phosphatidylinositol-3-phosphatase
- Probable inositol 1-monophosphatase ImpA
- Diacylglycerol kinase
- Phosphatidylserine decarboxylase proenzyme
- Inositol-1-monophosphatase SuhB
- Putative cardiolipin synthase
- CDP-diacylglycerol--serine O-phosphatidyltransferase
Sequence:
DAGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLANRLPRVSWVIPNVLESEHPAVPAAAGAFAIVNILRILLANPAVWEKTALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPYRVPDPQIMPTQETTPTRGIPSGPC
Protein: Uncharacterized protein (Q38FP7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- uracil phosphoribosyltransferase
- Uncharacterized protein
- Probable eukaryotic initiation factor 4A
- BTB domain-containing protein
- Protein arginine N-methyltransferase 7
Sequence:
MLNYTYVEKGVTAPLSCDVSSKSQLSSSSADGLQCVMDASAGNGDCSRVFVEAPTCRSGPPALIGGPIPSFQKHQPQQKQPSQSQRPWLMKIAQRAPCVAASPGSAESSMVSGQQVHRWGQFGEGPRPVPQPPQPLPLPDATSFVDMSMENCVQNPSQQRVGPFHQVPPFVGMPPPGCGGLVPPLLAPAMLGTSGNGHNHQWRSTPRHYGYLSRSAPTAIATGPSTNDDAYIYHQIRQQMDEQNRYREHQQQQQHRYHQPHQVYHNFHHNSHHQQCFGGTINPSPPTFFYGEAPRTDERVMLPSDSAVSGGNKGIIPSYVDGRRCDTGDGSTSRETPPFFVEGSMRGPGVGQEDCSDALDRSVETEKSVAGPPGDSRYLNERRNSHGKNSNDGSRENNRTFGGTKHCSLDEGGHRGLPLHPNDAGKRCNQNACQYKSDGLFPLGENGGQGESYASTKINTTEKTNKLPGKVDEQGAAGCEVTAGQKTSQTDQGKPKAREGNLCISCNQELKPPALTMLGDHGHDTEMLHNQRQPYGEPTNLFGHTPTGVSPTCGPPAAEALGTKHHQGCSHKSPTAHRASQWEPVPPKDLQHYRSNIAVGIAYQGGYSCTESCASGERSGPVLLAGGGGHETVRSVAGNYMWKSPTSQHRRQPLEGSPTQMSGLTCGDGGGRATAQTPSSASPWSHARAPGHARHLPLHPPMYEQHGALEDLFDEGGADIPFEPQVYGNIVSFVCAVSPILLATRLVESPTASPKSATPGNEERTPSRGGHPPTFVEPLIPLRCIWESLDMPFACAVRLAQPVPLTPMRFPQETVVYSPFLSGFRLRFLESSATYAELKAMQSRSGDDSCNAFQRRPASGRTSPTCVCTGESGQGDTDHEPPLACTYPAITKSATGKDCATPRGSVETASTVRDGSEEMDDSSGVGWLTWGAAERPDQRSLVLEQVRDLAAQDPRYSVLLTANVTELDYQSWIAVLWRPVFDQNHCAKHNCGSFIVYYAPRPPRHEIAPLSQSSSALECMNKSWMSPVFRADRAALRWDMWAPSRREVSVAEQTTAQTPKSASPGCTAPLSPALSPSVAAGGIAAGGSAVVSNFEKPVDLNGSSADAAAAREASITSGVAHETTHTSPSLSFVDSTTNTASLGSHCGPTLQSADQPFYARIPVVGIIPNRCRADVWFMPCFRDGVPDPGHRRDIGATGVPPCGYYCAPLFLLTAALQLMSWNAVEEYERQLAKKVALHGGGGGDSSGLGTEGSASASVNGGGPPSGNAVAAGVSSFRAAQDEKPSGVKLLIDAAKYYRQYRESAHTDAQAGTPTPKLNLSGQEAGEVNGRCRTISPSVASNISSTPFTEPGAVVGGLPDFYQWAQFDGPLLKFAERYV
Protein: Methyl-CpG-binding domain-containing protein 4 (AtMBD4) (MBD04) (Methyl-CpG-binding protein MBD4) (Q9LYB9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing.
Subcellular location: Nucleus {ECO:0000269|PubMed:14605234}.
Interaction partners:
- Methyl-CpG-binding domain protein 4-like protein
- Heptahelical transmembrane protein 1
- N-glycosylase/DNA lyase OGG1
- Methyl-CpG-binding domain-containing protein 6
- Methyl-CpG-binding domain-containing protein 8
- Methyl-CpG-binding domain-containing protein 5
- DNA-
- Methyl-CpG-binding domain-containing protein 7
- Methyl-CpG-binding domain-containing protein 11
- Transcriptional activator DEMETER
Sequence:
MKEEEEIGKPAKPKAKKDVAPGRLIDTYAAQCDNCHKWRVIDSQEEYEDIRSKMLEDPFNCQKKQGMSCEEPADIDYDSSRTWVIDKPGLPKTPKGFKRSLVLRKDYSKMDTYYFTPTGKKLRSRNEIAAFVEANPEFRNAPLGDFNFTVPKVMEDTVPPDPKLGSPFPSTTTTTSEKSSVKQSHN
Protein: Multicopper oxidase 3 (EC 1.-.-.-, EC 1.16.3.1) (Q9VBK7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein Malvolio
Sequence:
MGQNFLRRLPANRVASCPWRFAMSKRESKSFASLVLIVLLIFASNPSQCESSKDDFPQAKFEWPSFAWMRNKTTKGTPALDLKNDYSQMELANFGDFDRHPCRRVCQQGQSQNCYYQLVVHNYQRLGPECQRCQFDERACASEHCIYGDGVANPVMAVNRMVPGPSIELCENDTVVVDVLNYLSEPTTMHWHGVHMHRTPEMDGAPFITQYPLQPGEVQRHEFKVDRSGSLWYHSHVGWQRGFGVAGAFVVRQTSQENQHSQLYDYDLVEHTLMIQDIFYEYNLQDVRNILVNGKGRNHLSQLPDNDNRHRYERLRVTPGYRYRMRVILNGIANCPVEFSIEQHRLLMISTDGNDIEPVLADGFFLTSAERFDFVLEANQYKKNYWIRIKGYEQCENRNIYQGAVLSYRGSARSELPQGDILDKPSSRAADEDLILVNDFRFKPANSTAISSLRQSLDKDNNVGTVALRSVDPVPWTRYTKFLTHYSSFGSRTAPNGEVLFQISDISYNSPGISLLQGRHLYQDDRYFCNKSSLAAEGRNCERELCECVNVMRLPAYRPLEMVVANYLDSTHPFHIHGFTFRLVGQGVLGNLNDLRNIQELDRRGRLPRLSEDSAAVAKDTVQIPGQGYIIVRFISNNPGFWLYHCHVEAHAVQGMVAVLKIGEDHQMKNIPARVRC
Protein: Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) (O15151)
Organism: Homo sapiens (Human)
Function: Along with MDM2, contributes to TP53 regulation. Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Subcellular location: Nucleus.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Cellular tumor antigen p53
- 14-3-3 protein sigma
- Ubiquitin carboxyl-terminal hydrolase 7
- Casein kinase I isoform alpha
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-C
- Cyclin-dependent kinase inhibitor 2A
- Polyubiquitin-B
- Serine-protein kinase ATM
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Protein: LD38919p (Ubiquilin, isoform A) (Ubiquilin, isoform B) (Q9VWD9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 14
- Ubiquitin-ribosomal protein eS31 fusion protein
- FI07626p
- Ubiquitin-ribosomal protein eL40 fusion protein
- 26S proteasome non-ATPase regulatory subunit 13
- Polyubiquitin
- UV excision repair protein RAD23
- 26S proteasome regulatory subunit 7
- Presenilin homolog
Sequence:
MAEGGSKRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTDTLQMHNIKDNLTVHLVIKAPTRNNEQPARQPADVRQTPFGLNQFGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPWGGANSGTNGTVGGSGAGNPTGDLPPNNVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAARLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSGASTNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSNNADNTQPPEVRYQSQLEQLNAMGFVNRDANLQALIATFGDINAAVERLLSLNQLSLS
Protein: Zinc finger protein 805 (F1MY86)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
MSHRGTARKAGGMQHAVAAAGQTVPGAPTARRFTVDDFEIGRPLGKGKFGNVYLARLKKNHFIVALKVLFKSQIEKEGLEHQLRREVEIQAHLQHPNILRLYNYFHDARRVYLILEYAPKGELYKALQRSHTFDEQRTATIIEELADALIYCHERKVIHRDIKPENLLLGLMGEVKIADFGWSVHTPSLRRRTTCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGNPPFESASTSETYRRILKLSVTFDDVAVTFTQEEWGHLDPAQRTLYQEVMLENCGLLVSLGCPVPRPELIYRLEHGQELWTVKRDLSRSTCAGDKGKPKTRESTTSEPSLFEGASVQEQLTQRVSEDSQLGQINNQEEPLERHEGCLRPEIEPQNGKLPGNPSCERGSLGTAGGVCSRIVEEQVPLGGAVHDRDSCGSGKDPLIQEEESLFKCNECGKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCTECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECTECGKAFNRRSGLTRHQRIHSGEKPYECMECGKTFCWSTNLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRVHTGRNPVNVTEVGRPFTSGQTSVNLQELLLGKDFLNVTTEENLLPEETSYSESDHSYQRETPQFSSL
Protein: Zinc finger 30C (O44122)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
METESMAPSSSAAAAATKLLVEITTDGIPKLHCPVCNKALVSLAGYVKHVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAGQERNAFVCEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHRRSRPDTCGQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSDSGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIYHIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAHDKELLYCEKCDKYMTGHDSLKNHERNFHSKKEPRTQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVHADTCGQLPLNAKATQYMGVQRGKLLMGAKPEAGMEYEETKTLIAQDVIDRDMPMAQELNFPSDGSAPLATAPLNYASTHLVPHIVLQTMQAEARRME
Protein: Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) (Q8NFM4)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21228062}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11549699}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Rap guanine nucleotide exchange factor 4
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 6
- Adenylate cyclase type 8
- Rap guanine nucleotide exchange factor 3
- Protein kinase C delta type
- Cannabinoid receptor 1
- Ectonucleoside triphosphate diphosphohydrolase 2
- Cancer-related nucleoside-triphosphatase
Sequence:
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG
Protein: Interleukin-15 (IL-15) (P48346)
Organism: Mus musculus (Mouse)
Function: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-2 receptor subunit beta
- Cytokine receptor common subunit gamma
- Interleukin-15 receptor subunit alpha
- Tyrosine-protein kinase JAK3
- Interleukin-2 receptor subunit alpha
- Interleukin-7 receptor subunit alpha
- Interleukin-9
- Interleukin-7
- Tyrosine-protein kinase JAK1
- Interleukin-21 receptor
Sequence:
MKILKPYMRNTSISCYLCFLLNSHFLTEAGIHVFILGCVSVGLPKTEANWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFINTS
Protein: Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) (Q6DRL4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with topbp1 by participating in cdk2-mediated loading of cdc45l onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Subcellular location: Nucleus {ECO:0000250}. Note=Associates with chromatin.
Interaction partners:
Sequence:
MASQNVVFAIDVDYRPEGTQNTTNAYQDHLKQWILRVLLSLGHRYGLEKVRWGYKFFNSRTVKSATLITRGSDFKELQEKVFSDFEEELHVKFTTEGKSPRSQEKSHKLKPSPACCVQNALKEILLDFQWDRPDLTSPTKVTLRPRRSSRSGRNIPLQDCDMLSVDKNVLFVVSECPRSKAELEDYLSMRREDSRHHKDINEQMLPKGLIDMLMQRNVVLHWADSGVFKADHVAKDYTGIETLMERLGLVGGQVVPMLSPCLPLMDQHPKMNSLLALGVDAFPIDSTNSYLHLSKRMQQQLFPPLGASFSWIADGTKRSCNVTLEPVSYRQRSLRAPVDVLLKGVLQSLDILSLSHSAIETWILQCPDAELGQEAFQHLKQLSTGGHAMLAEVSEGDVVCSAVLSVLSSCTAQITVLQPLLAQEGQLLPADLVSLDTTDISGDLPDVVSSVLSVMYDIMEEDDCSDHEKMPLVPDWANQELKQQSSSRSNGMVEGWFPLSDQSGISCHLMESMRLLHAAPEEKEKGEEYSDTQQEITSSLSEFYQSSTAGSSGSLRSKKRGTQCTPVRQKMKTMSRSLQMLNFARLNVKAQKTQGDSGSAGSGKGTEKGGKKSSGDRTKPGLLHFSSEEELLSHLGLTYQKAVENRTMSVPSQVQDLLSVVKSFLKSNTEASLLNLVQKHVLKSCQSIRQHYGNSSDDESKIRECQLQAVLRLELCKQTEQEDEEVVEQRVEDVADMLRNISRSKDAVYLSRFMQEEVLPLYMNSIPKVLADVYHSLGTQLPEALVAVLPSDFFSDESLAKDSVSVSLSSFSATQSNISSVGDHLEELRNRSAKKRRQSMITRHKSMTEAPQALRQIEMPRKSTRLAKPKLCVPIEKTAVEQPPLPKQPVQEVTKVRRNLFNQVTVSPSKKSKMPRSQSVSAVEGIKKRKRSDVDNDDRHTLLTKKVSETPLHKQVSSRLLHRQRTGRKSGESDVCIIEESPIKPAADLRRSPRIKSLTRRHSSVFYSSSQPRSRNLDRVVSSSQLSHSEGKGKFSVSSVRSPVRLLFGATQSPGRLRHTTVSSLEDQASKGLPLRCSSFENQNKTPQKLRSDALASAVGCRTPQSPRTPNRTVGDNGMALRGSPFQSPAAKSIVVETPMKSPLKGILKTPIKKSLLDCVSPNGAWLRSPGCKTPKKCVTWSPSPRKPVPENQVNVPDSPVFAKRHSPRLVTPGKNSSPEEKIVFKTPDKVPQRKSKTSPEIILRRLEIPVNIDPETCKSITRSGKIRTLSLPYKTSKGSDEFLPQSESGSFPFCNSPLKPNIQKTIQSPIPTHRMCTRSGNTPVKESCSPSSNSQGITGTSPSPRKSLSSAVAKSSPSPSFGPSRSGVGNQNNSSISNVEKHTDDDKIIVQNKANDEKAEEASSSDSQQFDCSEFSITTDDESIDISEAAVVKTQLVGGIKMNIAFSRKPSKSDVFEFEGKQTTSTGTPLTRSYGFRQTPDRRQREAEARLGYSSGKPKISTPRTRRTPACGKQSSPQPLTYEVEMEMQASGLPKLKLRRTDSFNAGDLPSSATKGMTSHLVHRNKTNLKAPQIDSPLVQSSRHPGCISPSLCSRATPAKGTPGKGVQTYICQSITPTHHPTSSQSPLASPLTPSPQSRGWPTPENLNSWPRKKRARIETCGNKEQVIKGVPLLEKTGVIEDPELEGIFRIQGVEELKESLSTPISQRKLGLRSSQVMDHQGSPEGMDWTETMAQMCDAKDSTKTEQFAWMGRKVDTPKVKKQVSASGIFALTQSPLLYKKSAVIKEATQFSGSKSELEISPLCQPRRRRTPSRTYSRKKLLD
Protein: Cyclic nucleotide gated channel beta 1 (cDNA sequence BC016201) (Q91WA8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLGWVQRVLPQPPGTPQKTVETAGPQPETESKPEANPQPEPEPQQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPVPEEAPPEVQALPPEEPMEGEGEAEAGPSLQETQVADPAQPTSQAQVAVAKVNRPSSWMLSWFWRGMQKVVPQPVCSNGGQNLAAGERDPDQGGAQIPEPCGTGDPGSAEASGTQDTEPSLWLLRWLEQNLEKVLPQPPPPSLAWKVEPEAAVLDPDPPGTPMQMEPTESPSQPNPGPLEPEEEPAAEPQPGFQSSSLPPPGDPVRLIEWLLHRLEMALPQPVLHGKAAEQEPGCPGMCDVQTRATAAGGL
Protein: Probable serine/threonine-protein kinase ireA (EC 2.7.11.1) (Inositol-requiring protein A) (Q55GJ2)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Seven transmembrane domain-containing tyrosine-protein kinase 1
- Seven transmembrane domain-containing serine/threonine-protein kinase 2
Sequence:
MTFSKTRNKIIFLLFLIIINIFNINAYIKDENEDDLSLLISTLDGNIYSFNYESGELNWDLKPNGGDSLYSTSQFDRKQQQSTSTSTEITKSSPSILIPTLDGSGLLFQYSNDRLHQVPFSLQELVNTSPLFLKELEDKSSTSSTSTTSESSKDENKVTMFIGNKKTSITVVDSQTGEIIKSMSKDGLWLTDEDDCPVNIIPDEALMFTRSDYQIIALDPKSGVEKWNLSVGEYIPHSTKSFYNSEISLNFEGLIEVASLSQRMYKIYIKKPEKTVVGISHNYWEHILTSSPVSIYAYSSKKHILKKLDFHRKVSPYSNSLIPVASTDLMIPSNFDRTFMFDDYYGQLFIVSPPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNNKNESDKSNLTPLTPYDPSKPNGANNNNNNNNDLLDSNKLKNYDIYLYSSIVILITSIIVFIRSKKNFNLINVNNNNNQNNNQNSNQNNNINNKKTPKKKKKKQKNKNNKNNNDEDDENEIENYNDNQNDLIDEFISTNSVIQQQQQQQQQLINSSNKINNGSGKIILDNGNVKIGKLEIITNKILGTGSCGTIVYEGKMEGRKVAVKRMLSQFVKFADREVSILIHSDEHTNVVRYYAKEEDDEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRVKISDMGLGKLLDNDDQSLTFTSDSHGWQPAEYLNGTNRNTKKVDIFSLGCVVYYLLTGAHPFGHRYNREKNVLKGKFDIDQIKHLPDIHQLVHSMIQFEPEKRPDIGECINHPFFWEVHKKLSFLVAASDYLEFEKPTSPLNLEIDSHVDLVTDGSGDWWLKIDQVLIDNIGRYRKYNGKSIRDLLRVIRNKFNHYRDLSPEEQTCLGILPDGFFNYFDLKFPQLFIVTYLFILKNLKNDQYFVQYYY
Protein: 3-hydroxybenzoate 4-monooxygenase (EC 1.14.13.23) (3-hydroxybenzoate 4-hydroxylase) (M-hydroxybenzoate hydroxylase) (Q6SSJ6)
Organism: Comamonas testosteroni (Pseudomonas testosteroni)
Function: Converts 3-hydroxybenzoate (m-hydroxybenzoate), and to a lesser extent p-hydroxybenzoate, to 3,4-dihydroxybenzoate (protocatechuate). Also acts on a number of analogs of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.
Interaction partners:
Sequence:
MQFHLNGFRPGNPLIAPASPLAPAHTEAVPSQVDVLIVGCGPAGLTLAAQLAAFPDIRTCIVEQKEGPMELGQADGIACRTMEMFEAFEFADSILKEACWINDVTFWKPDPAQPGRIARHGRVQDTEDGLSEFPHVILNQARVHDHYLERMRNSPSRLEPHYARRVLDVKIDHGAADYPVTVTLERCDAAHAGQIETVQARYVVGCDGARSNVRRAIGRQLVGDSANQAWGVMDVLAVTDFPDVRYKVAIQSEQGNVLIIPREGGHLVRFYVEMDKLDADERVASRNITVEQLIATAQRVLHPYKLDVKNVPWWSVYEIGQRICAKYDDVADAVATPDSPLPRVFIAGDACHTHSPKAGQGMNFSMQDSFNLGWKLAAVLRKQCAPELLHTYSSERQVVAQQLIDFDREWAKMFSDPAKEGGQGGVDPKEFQKYFEQHGRFTAGVGTHYAPSLLTGQASHQALASGFTVGMRFHSAPVVRVSDAKPLQLGHCGKADGRWRLYAFAGQNDLAQPESGLLALCRFLESDAASPLRRFTPSGQDIDSIFDLRAIFPQAYTEVALETLPALLLPPKGQLGMIDYEKVFSPDLKNAGQDIFELRGIDRQQGALVVVRPDQYVAQVLPLGDHAALSAYFESFMRA