wanglab/gogpt-training-data huggingface dataset:
Protein: Pyruvate kinase (EC 2.7.1.40) (Q94KE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- L-lactate dehydrogenase
- Cytosolic enolase 3
- Bifunctional enolase 2/transcriptional activator
- Enolase 1, chloroplastic
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
- D-lactate dehydrogenase [cytochrome], mitochondrial
- Malate dehydrogenase 2, mitochondrial
- Malate dehydrogenase 1, mitochondrial
- Inosine triphosphate pyrophosphatase
- Malate dehydrogenase, chloroplastic
Sequence:
MHSSHLLLEEPIRMASILEPSKSSFFPALTKIVGTLGPKSRSVEALSGCLKAGMSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPINFNGLAKAVKKGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVICLSRNAATLAGSLFTLHSSQVHIDLPTLTEKDKEVISTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRVKTNQLKWSFSGAFEARQSLIVRGLFPMLADPRHPAESTSATNESVLKVALDHGKHAGVIKSHDRVVVCQKVGDASVVKIIELED
Protein: Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1) (Q9NRQ2)
Organism: Homo sapiens (Human)
Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21690087}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O15162}. Cell membrane {ECO:0000305|PubMed:21690087}; Lipid-anchor {ECO:0000305|PubMed:21690087}; Cytoplasmic side {ECO:0000250|UniProtKB:O15162}. Nucleus {ECO:0000269|PubMed:21690087}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000305|PubMed:21690087}.
Interaction partners:
Sequence:
MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGYYSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQLDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDCMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHFDIHFPLDLDVKMKAMIFGACFLIDFMYFERSPPQRSR
Protein: Transmembrane protein (Q9SZR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Actin-related protein 4
Sequence:
MTEEPEKVSSSVLHQPSGDKKPEDVGIKPQDPASSSGFRAYPNGDSPMYPVFYPGLVPGSNPVQYEEQMNRGAGIYAVPVHQFGGHVAGLPSNYLIPLTYNVPTTRPNNEAETGGENQAQAGQGQQQQLPANQRHVVERRFQIAFQLDLFLILKLAAVIFLFNQDGSRQRLAVLVIFATIIYLYQTGALAPFVRWLSQGMHRAAVPPARPHRPAVRADNDPAAAVPLNENAVLEGEENEADNGNRARANANENENVDAGNQGNQWWGIVKEIQMIVFGFITSLLPGFHNIE
Protein: Malate dehydrogenase 1, peroxisomal (EC 1.1.1.37) (Peroxisomal NAD-dependent malate dehydrogenase 1) (pxNAD-MDH1) (Peroxisomal malate dehydrogenase 1) (Peroxisomal MDH1) (O82399)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Peroxisomal NAD-dependent malate dehydrogenase involved in fatty acid beta-oxidation. Reoxidizes NADH from the beta-oxidation and provides NAD for the conversion of fatty acyl-CoA to acetyl-CoA. Does not participate directly in the glyoxylate cycle. Required for maintenance of photosynthetic rates under photorespiratory conditions, and carbon flow during photorespiration. Supplies NADH reductant to the peroxisomal hydroxypyruvate reductase (HPR), which reduces hydroxypyruvate into glycerate in the photorespiratory cycle.
Subcellular location: Peroxisome {ECO:0000269|PubMed:17376163}.
Interaction partners:
- Malate synthase
- Citrate synthase 3, peroxisomal
- Citrate synthase 2, peroxisomal
- Citrate synthase 1, peroxisomal
- Citrate synthase 4, mitochondrial
- Fumarate hydratase 1, mitochondrial
- Citrate synthase 5, mitochondrial
- Fumarate hydratase 2
- Malate dehydrogenase, chloroplastic
- NAD-dependent malic enzyme 2, mitochondrial
Sequence:
MDPNQRIARISAHLNPPNLHNQIADGSGLNRVACRAKGGSPGFKVAILGAAGGIGQPLAMLMKMNPLVSVLHLYDVANAPGVTADISHMDTSAVVRGFLGQPQLEEALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLSEAIAKCCPKAIVNIISNPVNSTVPIAAEVFKKAGTFDPKKLMGVTMLDVVRANTFVAEVMSLDPREVEVPVVGGHAGVTILPLLSQVKPPCSFTQKEIEYLTDRIQNGGTEVVEAKAGAGSATLSMAYAAVEFADACLRGLRGDANIVECAYVASHVTELPFFASKVRLGRCGIDEVYGLGPLNEYERMGLEKAKKELSVSIHKGVTFAKK
Protein: tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (F1M8H2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Tryptophan--tRNA ligase, cytoplasmic
- Tyrosine--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Tyrosine--tRNA ligase, mitochondrial
- leucine--tRNA ligase
- Lysine--tRNA ligase
- Glycine--tRNA ligase
- Leucine--tRNA ligase, cytoplasmic
- Serine--tRNA ligase, cytoplasmic
- Valine--tRNA ligase, mitochondrial
Sequence:
MALFSVRKARECWRFIRALHKGPTATAAPQKESGERVFSGIQPTGIPHLGNYLGAIESWVKLQEEYDTVIYSIVDLHSITVPQDPGILQQSILDMTAVLLACGIDPERSILFQQSQVSEHTQLSWILTCMVRLPRLQHLHQWKAKAARQKHDGTVGLLTYPVLQAADILCYKSTHVPVGEDQVQHMELVQDLARSFNQKYGELFPLPRSILTSMKKVKSLRDPSAKMSKSDPDKLATVQITDSPEEIVRKFRKAVTDFTSEVTYEPDSRPGVSNMVAIHAAVSGLSVEEVVRNSAGVDTARYKLLVADAVIEKFAPIRSEIEKLKMDKDHLRKVLLVGSAKAKELASPVFEEVKKLVGIL
Protein: Copper-sensing transcriptional repressor CsoR (Copper-sensitive operon repressor) (Q5SHL1)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPHSHLHLDPKVREEARRRLLSAKGHLEGILRMLEDEKVYCVDVLKQLKAVEGALDRVGEMVLRAHLKDHVATAHERGDVEEIVEELMEALKYR
Protein: SD06302p (Q8MQL7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MARRKGSGRGKSTVNSRKSALETAREKAKDEPTANTSQDNKFDNNMENATTTTAKHYKTAGKQYKTNKVNNTRRATAAAAAAAAAATTTVTTAATPTKKRTYRETATATTVTQRSTNKANIAAAIALAAATEATASASASATATATDATLTASKAAATAAATTDAASGNSNSSSKPSTSTRDKLGEVPLPTVDSNHIISNNNNNNNNNNTSNNNNNNHHSDNSISENNYEFKSRDKASLSDSKMTLQQMAAVSSNQEPVAPNVANTMSNSSIINSQQTTVNATPATDEAPLGDRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPPTTPLANGHHLMTQQQSHQQVQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATLSPASFAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADADDGLSDQDAELSNSSVVYTNIITIIITIIIIILIIIII
Protein: Peroxisomal ATPase PEX1 (Peroxin-1) (Q581V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Peroxisomal ATPase PEX6
- Peroxin-13
- Peroxisome targeting signal 1 receptor
- Peroxisome assembly protein, putative
- RING-type E3 ubiquitin transferase
- Peroxisomal membrane protein PEX14
- Peroxin-7
- Peroxin 19
- Polyubiquitin, putative
Sequence:
MQHSSFEVSIDPSRTDSFVLVSNEFIRGNLLPYYGRNIPFVVPLRISDGHKNTYVGCLAHRPHNFAAFKLIISVTMATSLGVTNGAIVQCTAVFKFAKAATVLVRPSSVDESEVVEQNALRIEAQLLRQVQVVFPAMTLDVAVFDGVNAKMVVERIEDREGHEVTSGCAVMAEGTEFVVATRTRHVEQSGAPTWSVLRCLTWRKEKGFNNEATAGDANVEAVSLYMNPSTAARHHWSEGLVMGFWDLAKASQLLESKEVTSSFLRSNALKAPIRLVEGMEDGVCTSPAFIQASNIVVFPTLDENIPTATDRDCPSASTSPFSNQIPYESVVEVHGTAPQELREHLVCWFEEIKKLGPHHSKYGSNGNVLLCGGSGTGKTAIVGAVLNELHGVHINVVQCKAEKLLASLQRALVECVMCAPAVLVLDNFDAVAPAQKEESVLSVTGATKAILEGTLRCFTEALSLCGAASVLVVATCANRQCVNEGLRSAYCFTKVIKVEALDRKTRVALLKQLFPKESAEALEEVGDLMGNYTPFDMRKVSQPIKSSLDGGRVPFREAARGAIAAFTPLSHTGITFLKSEKASLQSVGGLAEARKVLYDTLVLPMKHPELFARLPLKTRSGVLLYGASGCGKTFVVEAIVNSENLNCIVVNGPEVFGKYIGQSEQKIRDVFERAQAAAPCVVFFDEFDSVAPQRGVDNSGVTDRVVNQLLCYLDGVESRKDVYVVAASSRPDLIDAALLRPGRLDKAVHCPIPSLEDRVNILTICFEQLQAELTLPEIKEIAEQTINWTPADLNGLASSASMVVNRRIIEKLSKRCEEREVEHNFAVLNVGKGTTREKIEDILRPSAAAAAREEALNVANRITIKDVRQAMGMTKPSLTKEHIWEQERIHRLFSKQEKSSTREVGRKLTQR
Protein: Pinopsin (Pineal gland-specific opsin) (P-opsin) (Pineal opsin) (P51475)
Organism: Gallus gallus (Chicken)
Function: Produces a slow and prolonged phototransduction response consistent with the non-visual function of pineal photoreception.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGDFQFQRRHAVSGCAFTWGWALLWSAPPLLGWSSYVPEGLRTSCGPNWYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEMLCCGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV
Protein: Arsenical resistance protein/arsenate reductase (P71942)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTETVTRTAAPAVVGKLSTLDRFLPVWIGSAMAAGLLLGRWIPGLHTALEGVQLDGISLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLLLNWVLGPALMFALAWLLLADLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQVAMFAALGWFYLSVLPGWLGLEQTTIATSPWQIAKSVLIFLGIPLLAGYLSRRIGEKTKGRNWYESRFLPKVGPWALYGLLFTIVILFALQGDQITGRPLDVARIALPLLAYFAIMWVGGYLLGAALRLGYRRTTTLAFTAASNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVGLVYVSLALRNRLAGPNATHDADKPSVLFVCVHNAGRSQMAAGLLTHLAGDRIEVRSAGTEPAGQVNPTAVAAMAEMGIDITANAPTLLTGGQVQSSDVVITMGCGDACPYFPGVSYRNWKLPDPAGQPLDVVRMIRDDIADRVQALIAELLATAKTR
Protein: Corazonin receptor, isoform A (RE49422p) (Q9VTW7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEDEWGSFDRLPSVPSASMDLETENEVVSNWSTLANFTRLVAGAAPEIVNYTLNMIDVGVGMATDISNLSVSTTPLPAYAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHLCPGKGGKSSGGGGNNNAYSLNRGDSQRTPSMLTAVTQVDGTGGSSRQMRAFRQQSYYRSSSNGTAGPGAAPFKEQVGLLHVGPGNGTPGGSVSSGATPQLIRKGSALLARQPSCLREQEHQQRLLLHEKPSTLVLSYDSQRGGVGVGVASGLLDNNERVSSV
Protein: Large ribosomal subunit protein eL38 (60S ribosomal protein L38) (P63174)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P63173}.
Interaction partners:
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL42
Sequence:
MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK
Protein: Syndecan 4 (Q0JY12)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MLVLSAAAAVFAESVRETETWVPLKNKAAIEDLESSGNSQNEDFEFTDLNQTDDEDGFDEDDEDDYDDMSGSGFADVIDDIEDEFVNNQIPDDKGPFAPRPTVDENILVQNNEVFLRGAPNQDLDNHSNVLMTHAGDDSLFNNTEVLAAVIAGGAVGLVFAILLIILLVHFVLRIKKKDEGSYDLGKTPIYKKAPTTEIYA
Protein: Homeobox-leucine zipper protein HDG6 (HD-ZIP protein HDG6) (Homeobox protein FWA) (Homeodomain GLABRA 2-like protein 6) (Homeodomain transcription factor HDG6) (Protein HOMEODOMAIN GLABROUS 6) (Q9FVI6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the regulation of time of flowering through the photoperiod flowering pathway. May repress FT.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Transcriptional activator DEMETER
- Histone-lysine N-methyltransferase MEDEA
- DNA
- ATP-dependent DNA helicase DDM1
- DNA
- DNA-directed RNA polymerase IV subunit 1
- RNA-dependent RNA polymerase 2
- Histone-lysine N-methyltransferase family member SUVH9
- MADS-box transcription factor PHERES 1
Sequence:
MNGQGDLDAVGNIPKPGEAEGDEIDMINDMSGVNDQDGGRMRRTHRRTAYQTQELENFYMENPHPTEEQRYELGQRLNMGVNQVKNWFQNKRNLEKINNDHLENVTLREEHDRLLATQDQLRSAMLRSLCNICGKATNCGDTEYEVQKLMAENANLEREIDQFNSRYLSHPKQRMVSTSEQAPSSSSNPGINATPVLDFSGGTRTSEKETSIFLNLAITALRELITLGEVDCPFWMIDPIVRSKGVSKIYEKYRSSFNNVTKPPGQIVEASRAKGLVPMTCVTLVKTLMDTGKWVNVFAPIVPVASTHKVLSTGSGGTKSGSLQQIQAEFQVISPLVPKRKVTFIRYCKEIRQGLWVVVDVTPTQNPTLLPYGCSKRLPSGLIIDDLSNGYSQVTWIEQAEYNESHIHQLYQPLIGYGIGLGAKRWLATLQRHCESLSTLSSTNLTEISPGLSAKGATEIVKLAQRMTLNYYRGITSPSVDKWQKIQVENVAQNMSFMIRKNVNEPGELTGIVLSASTSVWLPVNQHTLFAFISHLSFRHEWDILTNDTTMEETIRIQKAKRHGNIISLLKIVNNGMLVLQEIWNDASGAMVVYAPVETNSIELVKRGENSDSVKFLPSGFSIVPDGVNGSYHRGNTGGGCLLTFGLQILVGINPTAALIQGTVKSVETLMAHTIVKIKSALDLQT
Protein: Protein TRIGALACTOSYLDIACYLGLYCEROL 5, chloroplastic (Q8VY77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Facilitates lipid transfer from the outer to the inner plastid envelope by bridging TGD4 with the TGD1,2,3 transport complex. Required for endoplasmic reticulum-to-plastid lipid trafficking as part of the eukaryotic pathway of thylakoid lipid assembly.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:26410300}; Multi-pass membrane protein {ECO:0000255}. Note=Is resistant to both thermolysin and trypsin like an inner envelope-localized protein, but physically interacts with the outer envelope protein TGD4. {ECO:0000269|PubMed:26410300}.
Interaction partners:
- Protein TRIGALACTOSYLDIACYLGLYCEROL 4, chloroplastic
- Protein TRIGALACTOSYLDIACYLGLYCEROL 2, chloroplastic
- Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic
- Protein TRIGALACTOSYLDIACYLGLYCEROL 1, chloroplastic
- Protein FATTY ACID EXPORT 4, chloroplastic
Sequence:
MVLSDFTGVGVGFGFGVGCGFGVGWGFGGMPMNILGVGAGGGCGVGLGLGWGFGTAFGSHYRSSRLTFQGIELETADKREEVVANMSKNST
Protein: Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] (Q29451)
Organism: Bos taurus (Bovine)
Function: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
Subcellular location: Lysosome.
Interaction partners:
- alpha-mannosidase
- Beta-mannosidase
- Di-N-acetylchitobiase
- Alpha-N-acetylglucosaminidase
Sequence:
MVGDARPSGVRAGGCRGAVGSRTSSRALRPPLPPLSSLFVLFLAAPCAWAAGYKTCPKVKPDMLNVHLVPHTHDDVGWLKTVDQYFYGIYNNIQPAGVQYILDSVISSLLANPTRRFIYVEIAFFSRWWRQQTNATQKIVRELVRQGRLEFANGGWVMNDEATTHYGAIIDQMTLGLRFLEETFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKKVRKKTLQMEQVWRASTSLKPPTADLFTSVLPNMYNPPEGLCWDMLCADKPVVEDTRSPEYNAKELVRYFLKLATDQGKLYRTKHTVMTMGSDFQYENANTWFKNLDKLIQLVNAQQRANGIRVNVLYSTPACYLWELNKANLSWSVKKDDFFPYADGPYMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGPAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLSEGWRPCEVLMSNALAHLSGLKEDFAFCRKLNISICPLTQTAERFQVIVYNPLGRKVDWMVRLPVSKHVYLVKDPGGKIVPSDVVTIPSSDSQELLFSALVPAVGFSIYSVSQMPNQRPQKSWSRDLVIQNEYLRARFDPNTGLLMELENLEQNLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQGGGARYRLEKAPRTQFSGLRRELPPSVRLLTLARWGPETLLLRLEHQFAVGEDSGRNLSSPVTLDLTNLFSAFTITNLRETTLAANQLLAYASRLQWTTDTGPTPHPSPSRPVSATITLQPMEIRTFLASVQWEEDG
Protein: Isopropylmalate/citramalate isomerase small subunit (EC 4.2.1.33) (EC 4.2.1.35) ((R)-2-methylmalate dehydratase) ((R)-citramalate dehydratase) (3-isopropylmalate dehydratase) (Alpha-isopropylmalate dehydratase) (Citraconate hydratase) (Isopropylmalate isomerase) (IPMI) (Maleate hydratase) (Malease) (EC 4.2.1.31) (Q58673)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.
Interaction partners:
- Isopropylmalate/citramalate isomerase large subunit
- Methanogen homoaconitase large subunit
- 3-isopropylmalate/3-methylmalate dehydrogenase
- Threonine synthase
- (R)-citramalate synthase CimA
- 2-isopropylmalate synthase
- Dihydroxy-acid dehydratase
- Methanogen homoaconitase small subunit
- Pyruvate carboxylase subunit A
- Ketol-acid reductoisomerase
Sequence:
MRSIIKGRVWKFGNNVDTDAILPARYLVYTKPEELAQFVMTGADPDFPKKVKPGDIIVGGKNFGCGSSREHAPLGLKGAGISCVIAESFARIFYRNAINVGLPLIECKGISEKVNEGDELEVNLETGEIKNLTTGEVLKGQKLPEFMMEILEAGGLMPYLKKKMAESQ
Protein: Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) (Q5T9S5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26638075}.
Interaction partners:
- Coiled-coil domain-containing protein 14
Sequence:
MESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRRSISASDLTFKIHGDEDLSEELLQDLKKMQLEQPSTLEESHKNLTYTQPDSFKPLTYNLEADSSENNDFNTLSGMLRYINKEVRLLKKSSMQTGAGLNQGENV
Protein: Protein transport protein Sec24A, putative (Q580T3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
- Protein transport protein Sec31, putative
- ADP-ribosylation factor, putative
- Protein transport protein SEC23
- Protein transport protein SEC23
- Protein transport protein sec13, putative
- Protein transport protein Sec13, putative
- Sec16 Sec23-binding domain-containing protein
- Longin domain-containing protein
- Synaptobrevin-type vesicle transport protein, putative
- Syntaxin 5
Sequence:
MNFAVPPEYLASYVNAQAVVPKTAPPANLQHRFEDPHQMQNWGPQGVAPVTTDAHTTYGTHADQPQEYLPQQYQQGGQPITAQNSNKLYKASAPPHSPQPQQYLPTAPSPQQSDTVICWDVQLAKLHEKSTFLDHPTIPRFLHSYVDQDMSRLPPSLQYIAPANRTTMRPTAQVLPNTSKLADTLQLPLGIIFQPFADTRPAEVDFSQLGGRLIRCCRCIAYINPFTTFCEGGRRWQCMLCRHMNETPNEYFCQLDQQTGLRLDLLQRPELTHCSVDIYPSREFLRNPPQRPAFILLLDCTYHAIASGNLRAICEGVLAALDTMKDEDAIYMGVIGFSSTVYFFNMASTLQSPRVIVAPDIVWDDCKVEDNFKVEPIELPSSVNELLVNVKDSYPLLKELFEKLPEMCSDTKDVGCAFGPAFAAALSMLGNSGGKILASIDTMPSIGSGKLSPRFNISKLSNQPKEYTVLTEANEWYKHRALACSNSNISVDIFAGSAQDLDLATIAPLARLTSGKIYRCTPVTLNGISRQVHRVLTRYTAFEALLRVRTSKGLTVPNFYGHCHVREPDLLALPIGDEDSSYTVELKPTHDLKGNYAYVQIAVVHTSRSRERRIRVHTFQLAISGSIGQVVNSADSLAVASFLSKMAIDSAIKNPFQKVQQRIMERLLTTIRAVKTHNESHGQRGGYFMMPDSLRFVPQLLHGFFRSAAIGFSTSTPILPDERMAAISQVVCTAPQGIVPFFIGWTFEVYSPYVPPEELPQPIFSSQSFFKPDGVYLLHIGTALVLWYGRTTDPAVLNVLGLPSNSGETQAPKGPPQSQGREPRYLITDEQLIEIRRRLDELLWKLSDITRCGFTVSLEICQQGSKTIEPVLTRMMMEDEVRSLPNYASFLRDVWQRSSLIAK
Protein: Transcription elongation factor 1 homolog (P60002)
Organism: Homo sapiens (Human)
Function: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular location: Nucleus {ECO:0000269|PubMed:34108662}. Chromosome {ECO:0000269|PubMed:34108662}. Note=Associates to RNA polymerase II (Pol II). {ECO:0000269|PubMed:34108662}.
Interaction partners:
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB3
- Parafibromin
- RNA polymerase-associated protein LEO1
- FACT complex subunit SPT16
- DNA-directed RNA polymerase II subunit RPB4
- Transcription elongation factor SPT6
Sequence:
MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ
Protein: Cystatin-M (Cystatin-6) (Cystatin-E) (Q15828)
Organism: Homo sapiens (Human)
Function: High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain. Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance.
Subcellular location: Secreted.
Interaction partners:
- Legumain
- Protein-glutamine gamma-glutamyltransferase E
- Glucosylceramide transporter ABCA12
- Loricrin
- Cathepsin S
Sequence:
MARSNLPLALGLALVAFCLLALPRDARARPQERMVGELRDLSPDDPQVQKAAQAAVASYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAAGAQQEKLRCDFEVLVVPWQNSSQLLKHNCVQM
Protein: polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase 1) (A0A8I5ZRL9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAACRPCCLCLCLRPLSCGPLGRPRRHRALSYLQVRALWSGTRSRAVTVDLGHRKLEISSGKLARFADGCAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGSSDKEILTSRVIDRSIRPLFPAGYFYDTQVLCNLLAVDGINEPDILAINGASAALSLSDIPWNGPVGAVRIGMIDGECVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQDFCHAIKVGVKYTQQIIQSIQQLVKEIGVAKRTPQKIFTPSAEIVKYTHTIAMEKLYAVFTDYEHDKVDKAFVLICLFSIEKFPEVDQLEIIESFNVVAKEVFRSIILNEYKRCDGRDLTSLRNISCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESSIKSDQIITAINGVKDKNFMLHYEFPPYATNETGKVTGVNRRELGHGALAEKALCPVIPKDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPISSAVAGVAVGLVTKSNPEKGEIEDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGVPVKIIMEAIQQATVAKREILQTMSKTISKPRASRKENGPVVETVKVPLSKRAKFIGPGGYHLKKLQAETGVTISQVDEETFSIFAPTPTAMHEARDFITEICRDDVIYILFVLTKLISFCRDTGVMVKLYPNMTAVLLHNSQLDQRKIKHPTALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVLKTLNDRSSIVMGEPISQSSSNSSP
Protein: Serine/threonine protein phosphatase 2A regulatory subunit (A0A0B4KHP7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNEALDPTIKSSTSAATPTAAASETTTTAASSVVETTTTIAAATASAAESKNETTATNNNSNTSGSISSSSSNNIVIPASATNGIKESNSNLSTTTTAAAVAAATTVEGVAPAITSTIVVTGGTPPLSSLAAQLRRQGFAQSKANKLKDNTPPYDAPPPTPISKVLNITGTPIVRKEKRQTSARYNASKNCELTALIPLNEKTAASEREELFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRTLPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQQVESLAKTNPEWTKARRFNDCLPVSDSRALCDQYSENSDSAYDQSEQRARQPPPPLPPQKQAHQEPREVRQALATLTTLNNY