wanglab/gogpt-training-data huggingface dataset:
Protein: Aggrecan a (Aggrecan core protein isoform X3) (E7F537)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLSLLLLSMCLWVFSATASFDYIDTEPESPLRVSIPNELPLRPLMGDTLVLPCYFQDNTVNDPGAPTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGYPMTPTDASIKITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFEKAKAACIQNSAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPGVRTYGVRDVNETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLAWKGGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPHPDSRYDAFCYSETGDEGSGFFPLDLELTTDGDNGVLTVDTITESHTVISKPASTESEVQGEVVTYKPSVTTSVENPYTALDISHVLPSPPTSSVEKDPDFGSGLSQSNKTEDTMSATGVVFHYRGGNCSRYPFGFVEAQLACKSIGAVIASAQQLQAAYEAGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRSYGLRPADERYDVYCYVDKLRGQVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQGFDKCRAGWLLDRSVRYSINIPRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKEDLDLPLNESESQETVTEEKIVSISSHPALHRPEGTPIIAPSPTEPSGTEESVASSSGDLLSSGSGDQPSGSSVSSGDSSGTSSTDDLLTSGSGDQSGSGSSVTSGDYSGASGTDSLFSSGSGDRSSGSFSSSGDFSGASGTDDLLGSGSGEQPSGSFVSSGDFSGASGSGDMSSGSGSSSGSGSGLDILVTFSGIDTVFSGVGSTSGQLEEAGEGSTEILTFQLDQISGSGSGLGSGSGYSSEESGSTSDLSSSSGESGESGDLSGISSGSGFSEESSGFSGFASGIFPSGGSSDISFIDGSGIIMVDRPWMKISSFLTEQELGSGQVDFSGSGLFSGSGVSGDISGLSGEISGSSGDSSGISSDISGMSGDISGMSGDISGISGDITGMSGDLSGMSSSDHSGSGSGLAFSGVTFLGSGFTDLTEQSREQEASGLVFFGSGEGSGFRSGGYAIESGERSGDSASSDVIFFSNNDMVEMSNKPLQGMELGRGEVEYSGTVRLSSGSGDDQSVFISGHEWIPVTANTPSVKSTDPPPAELFDQGPSDLYSDTAGHLGPYLKPEEIINNLDAVPLAALSSTTETASLQRPAVVERPAVNDYLNPCEPNPCGAGVCSVKDGVGLCHCPPGLHGEECQFDSHSCEKGWTKFQGNCYLHFSKRETWLDAEQRCRDLNAHLVSINTPEEQAFVNSNAQDYQWIGLNDKTVENDFRWSDGTQLQFENWRPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGNKKERYQVNSIIRYQCSENFTQRHPPVIRCMADGQWEKPKVQCIPKVKFGLHDKSVHHSHKARTALEKQL
Protein: MHD domain-containing protein (D7SFR1)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MAVTNAVSWRSEGIKYRKNEVFLDVIESVNMLASANGTVLQSEIVGSVKMRVYLTGMPELRLGLNDKVLFEGSGRGKSKSVELEDVKFHQCVRLSRFDTDRTISFIPPDGAFELMSYRLTTVVKPLIWIETSIERHSHSRVSFIIKAKSQFKRRSTANNVEIIIPVPSDADSPKFKTSIGSVKYTPEQSAFVWTIKNFPGGKEYLLTAHLSLPSVMSEESEGRPPIKVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGEYEMRMK
Protein: Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (P46972)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. The two catalytic IMP subunits seem to have non-overlapping substrate specificities. IMP2 substrates include nuclear encoded CYB2, mitochondrially encoded COX2 and cytochrome c1. Required for the stability of IMP1.
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein.
Interaction partners:
- Sugar utilization regulatory protein IMP2
- Mitochondrial inner membrane protease subunit 1
- Mitochondrial magnesium exporter 1
- Protein SOM1, mitochondrial
Sequence:
MFRAGSSKRFLRNTLIAISWVPVLLTINNNVVHIAQVKGTSMQPTLNPQTETLATDWVLLWKFGVKNPSNLSRDDIILFKAPTNPRKVYCKRVKGLPFDTIDTKFPYPKPQVNLPRGHIWVEGDNYFHSIDSNTFGPISSGLVIGKAITIVWPPSRWGTDLKLSTGRDCISKRAILE
Protein: F-box protein 3 (E9PJM3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAMETETAPLTLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYWLISEEEKTQKNQCWKSLFIDTYSDVGRYIDHYAAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVKNVVSGGFPIIRDQIFRYVHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSKDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKIFNVAIPRFHMACPTFRVSIARLGYLMTSVTVTPTLETIT
Protein: Spermatogenesis-associated protein 32 (Acrosome expressed protein 2) (Q66H17)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Spermatogenesis-associated protein 31
- Alanine- and arginine-rich domain-containing protein
Sequence:
MGVTGFSAFPCCGKNSVNIVERKNDDYHHHHHPLEDNKDEDNEMGTELSSMKPPPKVDPDPVPHLEDMVTELTSTPIPETENPEQQNYRIESIKPYEEELTTTNTFKPRGFNVNSTNKEEEEVVCGHFRSTPVQTSKHLFWSNKLIQASEHSLQTALEKHHKSPGEKKSISIAQVYTECTQRPSSTQVSRTPTPTALGLADLINFASSLAVASSSNMALPNLGTMIKGTSEKAQNTSLDFCQPIQSIKFTQATQITQISSEKQDEPPEVMAHKSWTQETRNVACSYLDINESGLKKATIQGEVKFVQAPATSPELQEDKDDSVPGTKKGTPILLKIHFKLSSPQAPEK
Protein: THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) (Q86V81)
Organism: Homo sapiens (Human)
Function: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability. Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling.
Subcellular location: Nucleus {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332, ECO:0000269|PubMed:28418038, ECO:0000305|PubMed:18974867}. Nucleus speckle {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Cytoplasm {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:28418038}. Note=Colocalizes with the core EJC, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:19324961). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}.
Interaction partners:
- THO complex subunit 1
- Spliceosome RNA helicase DDX39B
- Eukaryotic initiation factor 4A-III
- THO complex subunit 3
- THO complex subunit 2
- SAP domain-containing ribonucleoprotein
- Nuclear RNA export factor 1
- Regulator of nonsense transcripts 3A
- Nuclear cap-binding protein subunit 1
- Regulator of nonsense transcripts 1
Sequence:
MADKMDMSLDDIIKLNRSQRGGRGGGRGRGRAGSQGGRGGGAQAAARVNRGGGPIRNRPAIARGAAGGGGRNRPAPYSRPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDAQRRPAQSVNRGGMTRNRGAGGFGGGGGTRRGTRGGARGRGRGAGRNSKQQLSAEELDAQLDAYNARMDTS
Protein: Putative RING-H2 finger protein ATL49 (EC 2.3.2.27) (Protein MATERNAL EFFECT EMBRYO ARREST 16) (RING-type E3 ubiquitin transferase ATL49) (Q9ZV53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in female gametophyte development.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable E3 ubiquitin-protein ligase ARI9
- Probable E3 ubiquitin-protein ligase ARI5
- Probable E3 ubiquitin-protein ligase ARI7
- E3 ubiquitin-protein ligase UPL4
- Defensin-like protein 6
- Interferon-related developmental regulator family protein / IFRD protein family
Sequence:
MNKILPEMKSTQNLISSSPPPPLIPLKSNTSLSNLNSKITPNILLIIIILSIIFFISGLLHILVKFLLTPSRESREDYFDNVTALQGQLQQLFNLHDSGVDQSLIDTLPVFHYKSIVGLKISPFDCPVCLCEFETEDKLRLLPKCSHAFHVECIDTWLLSHSTCPLCRSNLLSGFSSHHNLSSSYLLVLESEQSSRDMVPVLESNSQLGYDVNNDSESTRIRSGRKSCDPDGDMDGLDEKVVPLEVKLGKFRNIDHVGEGSDQKKNSISGNSKNVDGRRCLSMGSYEYIMDQEATLKVHVSTKKLSGKDRVPSHRTVMSECGFDPTVKGIEKSVVERESFSLSKIWLRGKKEKQKGTSARDSDCSFVSSSSLRFPNHRIPPEESLKSENSESLETKTPSFARRTMHWLAGRQNKIVQPSTSNV
Protein: DiSHevelled related (B1Q240)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSIKLGARDRALPSPSGSSNTPSTSSDMIRSLLFTSKERKVRSTYTAPPPNRQHSPGVVSQLINKIELKTSPTNTSSRPKKKKKAPPLAKIDDLDLVDDEKTIVSEVVKSPRRKKYTGNPLGNLKILNNILPSSKASDDKENSGSQQQPSTGKKLKKSRSKSRVEPESEAPFRLKRTLTDLTNNHTPAGSTWRQMVSNALGGPLKKRLSEGALLFPGTSKASDDCNDEEGDNTKTTTKRRFLQRRKQSEKSAGGANGKESGGGSASSSFFGALIRLSHSAASLTSLTSLGGSKSRSASPSPSSSRSNTKEFKENLSPPQPPPPDLIAPAAALARPTFSLAAPDSPVSLAPPSRELRKSKTCQITTDRPPIIPSITISESRSLNRIDRCRPVTVDGSGLSSDCRPLVSRRSTMSRTMSLIPTSPSLPPLYEEETASTAAMVEEERADRAQKRRMRRYGGSNTTSTYQGRKDVAPDASPRRHLIGFLHRTSHLSLTSELSADASFYLIGHRRHLEESTIGSESDARVFSDDDDRGSTTTDFTSVSRQHEKMAKKKKNKRNFRKPSRASSFSSITESSMSLDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFENGQSCFTIPRNSREEPVRPIDTQAWIQHTNAMRGMPSIVEESAPTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARFRNEDGGPKYQWTIGMNGMSAGNGSSVMLPPPHLPGGMAGPPGAFKGMAPSMVSDGESRMYVMHI
Protein: 2-Hydroxyacid oxidase 1 (HAOX1) (EC 1.1.3.15) (Glycolate oxidase) (GOX) (Glyoxylate oxidase) (EC 1.2.3.5) (Q9WU19)
Organism: Mus musculus (Mouse)
Function: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate. The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (By similarity). Can also catalyze the oxidation glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate (By similarity). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:Q9UJM8}.
Interaction partners:
- Alanine--glyoxylate aminotransferase
- Glyoxylate reductase/hydroxypyruvate reductase
- 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- 2-Hydroxyacid oxidase 2
- Catalase
- Glycerol-3-phosphate phosphatase
- D-amino-acid oxidase
- Alpha-amylase 1
- Pancreatic alpha-amylase 2a5
- Albumin
Sequence:
MLPRLVCISDYEQHVRSVLQKSVYDYYRSGANDQETLADNIQAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREISRQIVKRAEKQGYKAIFVTVDTPYLGNRIDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDITWLRRLTSLPIVVKGILRGDDAKEAVKHGVDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
Protein: Ornithine aminotransferase (OAT) (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase) (P38021)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the interconversion of ornithine to glutamate semialdehyde.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Arginase
- 1-pyrroline-5-carboxylate dehydrogenase
- Amino-acid permease RocE
- Glutamate 5-kinase 2
- 1-pyrroline-5-carboxylate dehydrogenase 2
- Glutamate 5-kinase 1
- Catabolic NAD-specific glutamate dehydrogenase RocG
- Acetylglutamate kinase
- Transcriptional activator RocR
- Argininosuccinate synthase
Sequence:
MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEYKRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRNA
Protein: Probable conserved transmembrane protein (P96401)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable conserved transmembrane protein
- Esterase LipC
- Probable conserved integral membrane protein
- Enoyl-CoA hydratase EchA19
Sequence:
MFDIATRFKNSYGSGPLHLLAMVSGFALLGYIVATARPSALWNQATWWQSIAVWFVAAVVAHDLLLYPLYALADRILARLVGRRDVSAPRRRPELPVRNYIRIPALAAGLTLLVFLPGIIRQGAPTYLDATGQTQEPFLGRWLLLTAVAFGISAAAYAIRLVVAHVRRRRAGCSRVDAIDEE
Protein: Transmembrane protease serine 11G (EC 3.4.21.-) (Serine protease DESC4) [Cleaved into: Transmembrane protease serine 11G non-catalytic chain; Transmembrane protease serine 11G catalytic chain] (Q5QSK2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000269|PubMed:15558215}; Single-pass type II membrane protein {ECO:0000269|PubMed:15558215}.
Interaction partners:
Sequence:
MYQPGILGRRKRVCKPWTVALTTTAALLALAVLIGLLVYFLVYEEKTHYYQASFWIPSIKYSSDLSEEQSKLQINLKQKINNEIDVIFQRSSLKHHYVKSQVVNFRPSNDGVKADILIKFQIPRKNADTLRSEADSILNKKLQSSQSFLKRDISLPYLREMNAAQAEHILNSNCGLGMEYPRIARIADGKPAGSNSWPWQSSLQVEGIHLCGASLIGSQWLVTSAHCFDNYKNPKLWTVSFGRTLGNPLTTRKVESIIIHENYAAHKHDDDIAVVKLSSPVLFSENLRTVCLPEATFQVLPKSKVFVTGWGALKANGPFPNSLQEVEIEIISNDVCNQVNVYGGAISSGMICAGFLTGKLDACEGDSGGPLVISDNRNKWYLLGIVSWGIDCGKENKPGIYTRVTHYRNWIKSKTNI
Protein: Cytochrome cd1 nitrite reductase (Q3LGA9)
Organism: Hydrogenobacter thermophilus
Interaction partners:
Sequence:
MRKRKKVLIGGALVFVLFAGTYAQQQQKEELPPPPPLTKQEMERAKEIYFDRCAGCHGALRKGATGPALTPDKTRKLGTETLKTFITYGTPGGMPDWGRQGILTPEEVDLMARYIQHDPPPPPELPLGEMKKSWKVYVPPEKRPQKPEHNRNWQNFMAVILRDIGKVAIIDGDTKELVSTVDTGYAVHIARYSASGRYLYTIGRDGKVVLIDLWMKKPDKVAEVKTCYDGRSLDTSKYKGPKGDFLDKLAIIGCYWPPSFVIVDGQTLEPLKIVATSAYTYDTNEFLREARVASMVASHYDPEWVVNVKEAGQIWLVDYSNIHAPKITMIDAERFLHDGGWDASKRYFLVAANFRDTISVVDTKEKKLVKNIKVGTRPHPGRGANIDHPKYGPLWCTGHLGDNTIRCIGTDPVKHPQYAWKVVVKMEMPGEGGGNLFIKTHPKSPHLWADRALNNDPKLQRSLFVFDKNTFQIKKVIEIPPEFQGRAVHLEYNKNGDEVWVAVWSKKNEPEKQAILVYDDKTLTLKKAITGNWVATPTGHFNVYNTMKDIY
Protein: Pyridoxine 5'-phosphate synthase (PNP synthase) (EC 2.6.99.2) (Q3V891)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00279}.
Interaction partners:
- pyridoxal kinase
- Holo-[acyl-carrier-protein] synthase
- Pyridoxal phosphate biosynthetic protein PdxA
- GTPase Era
Sequence:
MPILVVNVDHVATLRQQRLGIEPDPVTAAHMAELAGARGIIVHLREDRRHIQDRDVSLLRQTLKTRLHLEMAATEEMQGIALAEKPHMVCLVPEKREELTTEGGLVVAGRVDFLQAYVKPFHEIGIATSLFIEADPDQIRAAARVGVTHVELHTGHFADAPDAAERKRQRDAIVAGIGLARTLGLKVNLGHGLNYDNIFDFEAVPGICEFSIGHSIVSRAVLTGFGPAVRDMVDIINRFPG
Protein: Signal transducer and activator of transcription (E5F1H4)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- IRF tryptophan pentad repeat domain-containing protein.
- Signal transducer and activator of transcription 2
- Interleukin-4 receptor subunit alpha
- Interleukin-13
- Interleukin-4
- Cytokine-inducible SH2-containing protein
- Tyrosine kinase 2
Sequence:
MSLWGLVSKMPPEKLQRLYVDFPQHLRHLLGDWLENQPWEFLVGSDAFCCNMASALLSATVQRLQALAGEQGEGSTILQHISTLESIYQRDPLKLVATFRHILQGEKKAVMEQFRHLPMPFHWKQEELKFNTILRRLQHRVGETRLLRKALQPGAEAGQVSLHNLLETPAKGTGPSEALATLLQETVGELEAAQALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRAALISRLDEVLQTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSMPQGPGAGAESTGEIINNSVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFVLGPNKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPEPQMPTMVPTYDLGMAPDTSMNMQLSPDMVSQMYPPHSHSIPSYPAIPREESVSVLSAFQEPHLQMPPNLSQMGLPFDQPHPQGLLPCQPQEHAVSSPEPLLCPDVTMAEESCLSQPVGGFPQGTWVGEDMFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSLYGQSGISMSHLDLRANPSW
Protein: Ribonuclease P protein subunit p29 (K7ERD7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQSLFLPLHELWKQYIRDLCSGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKLNCV
Protein: Probable Rho-GTPase-activating protein 9 (Q9UUJ3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MWDGFSNSFWSRDYITGINRAQRLINEGVEQNEKLLQLLHIRAKSASSCSDLLFKSFSKFNKHHPLNEESNDLPSDAAIHQLYESYLMEASLHKKLGEQLNILVINPFANWSKKYSRRVDEIVSAAIVKINNYNSRFSHVNSKKSNLTDRKPIPTSRKSNKSDSLASALSQLDINPSNVNKFDGLINIVDHPYTAEEFANVLLKLMKASTVKRKSYSHLGDYELVTNCSLLFEAIKTTFGLEKDSYVVKAGNQLIQHGLIRLLGIRRVFENDPEIDAQFTTKSQQLLKSYHLSILEVDPYFQVNDPITATNDDPVLQKYNLAYDNLEQCRHELELYLFMVFKDLEQAELDRLNAVKSVLVECSNYSGNFIPSLNSIFIDNLNSFKNLDSLRDMSTQINKHYTGYFIPVSNNELSTKDEYLFLQKSSLTEDNLIVSLVPKILAYLLDAYSYERDEEVLSCVWTTEVPLKDAFDLKSVLRKTDNVESVLNACVEKYTLSSITCSLRLCLLEFPDSLIRSSFYDYFKAIYTTYTDFEDLDHRLYSIKKCLLHLHSTPLHILEEIIRHLSAYAISIRMKDGQIRHLAKIISPCVLRPPDDLNIIPVEDTHPTLLVIDLINEFENLFADLERPSTPPVEIERALTPITTSPQKLKLPRSSSPCKNPSPTRRFRPF
Protein: DNA polymerase I B, chloroplastic/mitochondrial (EC 2.7.7.7) (DNA polymerase PolI-like B) (AtPolI-like B) (Polymerase gamma 1) (POLGAMMA1) (Q84ND9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria.
Subcellular location: Mitochondrion. Plastid, chloroplast.
Interaction partners:
- DNA polymerase I A, chloroplastic/mitochondrial
- DNA repair protein recA homolog 2, mitochondrial
- Twinkle homolog protein, chloroplastic/mitochondrial
- Single-stranded DNA-binding protein WHY3, chloroplastic
- DNA repair protein recA homolog 1, chloroplastic
- DNA repair protein recA homolog 3, mitochondrial
- DNA mismatch repair protein MSH1, mitochondrial
- Single-stranded DNA-binding protein WHY2, mitochondrial
- F5O8.30 protein
- 5'-3' exonuclease family protein
Sequence:
MGVSLRHLSPSSFWVSRRPRVSSSILSFLVPRRRILCTRKVAIIKGNAGYSTATDCGGSHGFHHSGHQRSSSVEFSGEWKLNLGSKTARMVPPTVKQAGAVSAWREEVNNKLRGRNREYANNQDDAFGNGSYILKGFVPKIDDVHSYGNGQNFDYNLKPGTDITTLGRELNGFMQTNSIRGSVVALPSKDIEVGETTDVTLKPLNSDTTLDNASYKKTATISKVEKCTNLSQVRANLKKIYNRVRVVDNVSSAKETVALLMNQYRNLVHACDTEVSRIDVKTETPVDHGEMICFSIYCGSEADFGDGKSCIWVDVLGENGRDILAEFKPFFEDSSIKKVWHNYSFDNHIIRNYGIKLSGFHGDTMHMARLWDSSRRISGGYSLEALTSDPKVLGGTETKEEAELFGKISMKKIFGKGKLKKDGSEGKLVIIPPVKELQMEDREAWISYSALDSISTLKLYESMKKQLQAKKWFLDGKLISKKNMFDFYQEYWQPFGELLAKMESEGMLVDRDYLAQIEIVAKAEQEIAVSRFRNWASKHCPDAKHMNVGSDTQLRQLFFGGISNSCNDEDLPYEKLFKVPNVDKVIEEGKKRATKFRNIKLHRISDRPLPTEKFTASGWPSVSGDTLKALAGKVSAEYDYMEGVLDTCLEENIGDDDCISLPDEVVETQHVNTSVESDTSAYGTAFDAFGGGESGKEACHAIAALCEVCSIDSLISNFILPLQGSNVSGKDGRVHCSLNINTETGRLSARRPNLQNQPALEKDRYKIRQAFIASPGNSLIVADYGQLELRILAHLASCESMKEAFIAGGDFHSRTAMNMYPHIREAVENGEVLLEWHPQPGQEKPPVPLLKDAFASERRKAKMLNFSIAYGKTAIGLSRDWKVSREEAQDTVNLWYNDRQEVRKWQELRKKEAIQKGYVLTLLGRARKFPEYRSRAQKNHIERAAINTPVQGSAADVAMCAMLEISNNQRLKELGWKLLLQVHDEVILEGPSESAENAKDIVVNCMSEPFNGKNILSVDLSVDAKCAQNWYAGK
Protein: DEAD-box helicase 3 X-linked (A0A0J9YVQ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGELGA
Protein: Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123) (P26952)
Organism: Mus musculus (Mouse)
Function: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (By similarity). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Expressed on the cell surface.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system; Single-pass type I membrane protein. Note=Mostly distributed inside the cells, except in the nuclei and is not transported to the cell surface.
Interaction partners:
- Interleukin-3
- Cytokine receptor common subunit beta
- Interleukin-3 receptor class 2 subunit beta
- Granulocyte-macrophage colony-stimulating factor
- GTPase NRas
- GTPase KRas
- GTPase HRas
- Tyrosine-protein kinase JAK2
- B-lymphocyte antigen CD19
- Interferon gamma
Sequence:
MAANLWLILGLLASHSSDLAAVREAPPTAVTTPIQNLHIDPAHYTLSWDPAPGADITTGAFCRKGRDIFVWADPGLARCSFQSLSLCHVTNFTVFLGKDRAVAGSIQFPPDDDGDHEAAAQDLRCWVHEGQLSCQWERGPKATGDVHYRMFWRDVRLGPAHNRECPHYHSLDVNTAGPAPHGGHEGCTLDLDTVLGSTPNSPDLVPQVTITVNGSGRAGPVPCMDNTVDLQRAEVLAPPTLTVECNGSEAHARWVARNRFHHGLLGYTLQVNQSSRSEPQEYNVSIPHFWVPNAGAISFRVKSRSEVYPRKLSSWSEAWGLVCPPEVMPVKTALVTSVATVLGAGLVAAGLLLWWRKSLLYRLCPPIPRLRLPLAGEMVVWEPALEDCEVTPVTDA
Protein: nicotinate phosphoribosyltransferase (EC 6.3.4.21) (C6KTC6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- nicotinamidase
- IMP-specific 5'-nucleotidase 1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Glutamine-dependent NAD
- Glutamyl-tRNA
- Bifunctional dihydrofolate reductase-thymidylate synthase
Sequence:
MQGNRENSKGSHNEESVSSTLGKEQTGQGKSNIIENIKVDKNKKIIYLYDVAITEDELEELLKSKRKEQKNETCNYKKVCYNYEMNGKNVEHNNVVEEKGTLCNSNVDSKCSWIDDNHKVISLMRCQKYIIENRINKDIDIPHNNTINALFMDYYHLVMAYTYFKQNKHEDKSIFEVYFRKCPFNGQFAILAGVYEVIKYINCFRFTKAQLDFIRKKMSSYNDIDSFVQYLEKISGNDLCIYGMEEGSVVFPNEPLMVIEGPLLICQILESVILNLMNYPTLISTNSIMYKFSINNKTLAEFGCRRAQGPDGALSGSKYSFCGCDFTSNVYASYLYDIPILGTMSHSFISSFHNTEKLISNLLDNHDFVSIINKNKNIVHKLYDCKYTNESELIAFSAFAQINPKNFICLIDTYDTLKSGIYNFLIVALSLYEINYKPIGIRIDSGDLRSLTNECKNIFNDISQKLNVPFNQLKICVSNDINQKIINYLNEEQNHIDIFAIGTNLITCQSQPSLGLVYKLVQINNAPCFKMTNENKKSNLPYQKNVYRIYTDQQFATLDYIQLYNEQPPILNQQTISINIHDEWKQTIIIPKKIEQKLCLIWKYGKSLITFKNIYDLKKYTQSEINNFKNEHFKTVSPVPYPVLFSDTYHKVYKDLLIKNSHINQ
Protein: Tafazzin family protein (Q810E6)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side {ECO:0000256|ARBA:ARBA00004137}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00024323}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00024323}; Intermembrane side {ECO:0000256|ARBA:ARBA00024323}.
Interaction partners:
Sequence:
MGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSTLPVLERLRAENKSAVEMRKALTDFIQEEFQRLKMQAEQLHNHFQPGR