Protein: Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: N7-guanine methyltransferase (EC 2.1.1.56) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2); 3C-like serine proteinase (3CLSP) (EC 3.4.21.-) (M-PRO) (nsp3) (p27); Non-structural protein 4 (nsp4); Non-structural protein 5 (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp9); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp10); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp11); Non-structural protein 12 (nsp12); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp13); Putative 2'-O-methyl transferase (EC 2.1.1.57) (nsp14)] (Q008X6)
Organism: White bream virus (isolate Blicca bjoerkna L./Germany/DF24/00) (WBV)
Function: Catalyzes the RNA N7-guanylyltransferase reaction to methylate the core cap structure GpppN-RNA into the type-0 cap (m)GpppN-RNA.
Subcellular location: [N7-guanine methyltransferase]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Non-structural protein 2]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Non-structural protein 4]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSILFGNRQANATKRSDMASVARAVYEVDLISTKYARRTQERLAHNKHAKPSYPSVFFGRRMKAVKEPTFTPSTLFFEEATLPKVLASKAKPDTGIKTRRVYVADSLTINGHTYPIVGHFVEMAVSKKEAFPIQPKRVKPKPLMAKPIPNIRRTFLTPEERTNTPTTPTTTTTTPFVAGETAGPTIEYTPTSIDLPFAMPTVKQIKENAHTILREQDDCLRFAQTALFKHLGTVTHTTPNHATTFQVKGRTSLLTFEWRKTTQSPLTDGHFYLQTANNHAELMQPVEGKLTTIFTTTIQQGTTHSLHLIKQESARTLKTRKPLKLVTYKQETPTTTITPQSLKKTITYIPGSFCINVAEPTLQSVMRRQPLTPTPNDALLQIYHKLGCTTKSPNHASTFELFGNTYTWYPVQHTNNLLHKDPNRRFFLHITGQTPQLLIRTERKTFLTLQDEVTYISGKLFVMNHAPIQGEYKTQTAEWVGSYNMAKTPKAIKPAKTVEYINTTPCHKPATMPAPITYRQCPYTWTLHEPSISKVQRNLFHIPKTATNCLDRIQKALFPEIVTSNQHFPIGFTIQTDTTMQSYEWAILCKKVTRTYYLAVQNHHATLWYKCAQVYMCLSDDIAPTTELQGSVYILNKVTDPGFYQNTRQWCGSNDDLHEPKHLIKNLANGDVNNIAHCSLTPWTTTPLVYSTQKNKLTRKLIHYYNATYTVQVPKENPNAQPSTMKCAYKAYIDLATPTELQIHLDLEIQGKLYSQTAQKKGSKFNKLDIPTFGDILKGTLYVFSSKVLLYEQPKRCTSVCFHLPNNAQSFFFNTETIQTFEDLFARISSEEVEDNLVLIKGFVPCLGAIYITKDLKFIQPELKEDFKHPTTYYTFTTTVDPEQVLYSLHPSFTDIVPPHGFPYYTFAKLNNHIDAWNITDDQADTLAEAQPIIFQWPTEEATITTPYKVLHYEHLEGLDYISLSSFNTVECPEETQSAHDSSSESESEDEELPAHPLSNAPSQASLSSVASTAPPTSPTSSPTPSPTPLQQQVGLKGKEVPVGGWVLVSEEETPSEEVDSPKLLPNEVPLSFDFDLPIEPITRPISPELQQPILTHYEHPTSPTPSVEIEIDFGSYENLTLQTEETVTTEVQPEPTPAPTPEPTIVTETVQETPVPTETTQESTPESTPESTPEPTPESTSESTLEPEHVATPSQSPTHITVTEITHEPETPDSWSERYDSTSNIPEVFNQLSFGSTDSVKITTPKTETPDEPQQPTVETVSAAQQLLQIVQTATPDIAQLMSELPPYRLICIGSYCPILAENISKQLPTAVTTPTDADIPTVIFNVSEETMDTVINTVKTKHQANHLTFSLTTIIALDVPKDKSLPLQQIYDKLTQQDYNTDFIYESHHRQPKESLTHASVLSAYTASYKTTAIKSIADNAVVLDIGYGKGNDGPRYAVRPLTVTGIDTAARMLAIADQNKPENVTLVKQGFFTHITKTSNTYTHVIAFNSLHYPLASSHPDTLVQRLPTCPANILIPCHHLLEGIQTPTYSVVKDEDMWCVKVTKNEFIESSYNYDVFVKALESKYHVTIGSLLDCVEKPSTRSITPTLWTAMRNFVNNDQEMQRILSGYITFNLTPLPPKVEIINDWLDNNATVTINNPFASNEGVTFAVHNIGAITTTEGEFIVNAANKQLNNGTGVTGAIFAAHDKELKLTQAIKALPTYGASDKLESHQHVVQTIIKNNNSTHAINILHAAAPIKVKCTSKNPEVLLAHNETAQSELKETYKAIVDYAQLNKLTHIYLPLFGAGAYGHKPLDSLEAFLDAMRNRSPQSTTQYTLLLSDPVKPLDNPSFSYEFLNLLVTNLNINKQFAQLIVNKYHNTCALQSAIQMNTTTDTHNFLATFIYLLYTMPYSMNTFRQTHTPEEPFTPGKMVTVVDTTIAFLTTLDILPPCGQPCGYLPPSITKDGEYICACQKTSNWSLPFHFYNARYNKVYHTGLNNILTHKHSAFHKSRNAAHFIAKTGPSTSSYPVYMAPVPEILAYNASYRDSCQDNAIEEQSDSQASQSPSSPVTIPVSLPTASPASSVKSALRSDIPITTDQQSTTSASISTATTASTIPTAPLTSSDSNTSVVTSLYGNMEELTYLDASGTSQDFILSETTPFIAHIYHNNEATFIPPGYQLLDTNTNDPIEMYITPPRPIDGSPMISLASTASTTPMTYPLLSIRLTTEELTSFFKTKTDKFHLISHKSCLTVHLFDSPTLNSIAADSTSDAHLYQQHLKDLYTFSDCCSMYTRTEVYNCIEADTPLIRQSEQTKFHPINLDTLIEMVATFPPIVKRYSQTTTPDFTNLTVYFVSNGDIITTPTGSTSEQPPQLKIFLDYQTSSKFTTLVDLTLHEQTEANTIITYHHGEHQLLKPNPSAFYIEFQTYSSFFSRFQTFSTNFFWTLFINFLINVRFCITADSAYFHWQGKPIETTNLNIVYSIGRLDFVLSKHTTPWLTKPTDTLNPLTLIKNTLVQPIAINFHGRIRPLQSTNTRFGATHTPTKLPVHLLNTSLRTHYLSLLSLFQCTFSVFLAYIALLYSFSGHGIFTVVAYFTMLFARYYITSFINFCTSQLTATQVTQWFAAIKAKYTGIYESSQDRVLTVNVTGTNVPYIVKYSTILTVTMYVAFMAFVWTVSTYAAQYTAGERYDRPPYQTVFQKTLNVLGLTETVTYYYPYASLNEACAASTSILCRLGSPFNFHYPSDYTQVRTVQTDTSSPFWLFIIFMPPSFLFIVLPWLILCTITPTVSIAQLLVPSIILNATIVFIYIRRKFTGHCCGPHTCIKHADISRSLQFRPTSQIQHSLTFCGTLCAKHNWYCNNSDSPTHTLGIQLAQLIETTYKLQPGTIKPDSSYTHTTETATLPIMKVSTTSTDFTTSEPNTTVEHLHLQVIAHVTGTRISIESSSNKVQQQNTQHTRLTNKPVTGFMHTTLLQKLKRQHKDELSSYLCNFVPSDNKKDCILPHSVVHMTLTENQRTFLLKNFTFSTNVTVDPTTTGFIPSSLNISTLPHKHFMINVIESAMLAKLPKEVQDTLRTTHLETTTLERQAMSLTTQAILTTFALIMATFVVAFLAFFSTAQVGKTPYAGLNPTMVGNVNAEPYIQPTTLENSILIPLHGASKVCWRAQNGTLFFTDAIPTTECARAAVPYIGYKSEFTQTCASSNLRYPFTVYLGSIKVMYLRDGISYLTSTLSHNSNTKKLCVQVGSNAVRCASVLPTGASSNVAALLMASVVVISMVLFYLYLLQIFKFYTNSVIMSFVIQLLTLLATTVSTPLAVTVQLFVITYGYTNWILLTLSLLNLTVLLSTPVGITFVVIYGLYKAYTLFTSSGQGCVYNEGGTIRFSGSFEQVANSTFPLTNASCVQLLSDLGITYQQLNVYASSRDRNVRRLAQALLHRQLDSASECILYEGCSGNTITRQALQRIRQAVTVVVTPASQNLCKITSNQANGIGLSCTGTFFTSTEIITCAHGIGTSDITAVHKGITYDCKVKSINNDIAILITTTVNLSVQNIKLDSSFSQKSDNYQRNFVQFVSFVDQQNSDAVTINNTVMLPSGHFFAIGTEAGESGSPYTLNGNIIGIHYGIDNAGSWMLASRPDGSFYVPATQHGNSAKVTFSTDAFAQQFPAIVTNKTSDQLVNEIAATNNTAFELDTTDVSHLSNLLKHLKNNNETPKSLSDYLPVAPVTQQTSVTVGQTLTSPVNNMQTALYTLMLVSEVITYILTPNSDLSVLISMFVTSAFLKFGASKLFYNTEMLRNTITTFVVYRYTTLLIALVFSQYYLHILSYALKLNTLVLTVIALTFLVTPLVLLTIRRVYYYSQNYLISCVFIISCFASHTYTLYILTDTTVDFQTFIISEPIFSTLLCNLFIGFTLISVVPNPLYVCVVFMYILLDCEALGFIVTCFMASYLCPKPLRSLTTFLCTDTLVLTAPAYLHWYGAKGTQREYSVIYAVFDSILTPETTIQIPVTIMEGIEQQVKFIFAVPKSANIQDEEEAYVEYNQNSDIKDLAIKNEEKVCTITGMFRKTRTIKGTLMESFYPRHQPDSYILNQVVRHNYVLAHDPETIILTTVNPTHLESEPFQTIVKKVRKLHALYQEISEQSSDDTELCHAYILALIKSTVLEAQMPTEKINFVSSQTMLSPAMILIFAEAYQILTESRSFTNHITPQSDIGSMQTTLASLAEMDTDEMTPQERKIHIKRMNVLKQEIAKMESASLKLEKFLDNMHKAEISKRGKEDILLKVSNMLRLHLNKVANAAHCTIQTPSAGLITLASAFDVHSLCVTQHSESVLIQTPDDDTFLVYVDGQIYTCYNPTDITGKKLVPINVMSPDNVQFPTYPVVFSLSKQDYAEEITEQNNIGYTERTHNFKLKELASGLAVTLDGLVVVTETKELATAFKIGQRYFKFLNTNKTPVARNNTHAIIQLLRNNISQQAVVRIGGSRVSNDHIAISQVPVQTIGYLTYAGISVCRQCATKQDHTCQYAGYFVQIPREHVSNIFNLTDTPPCLHNKFTCTTCQPLQQQSKTQQPPLNLVGQCLGLTLDTAFCPFQTGEYKPSSREFYINILNNNVASLRKVFKKNTASIPSENGTIMLKDTGTAHEIYVAKQLLAKGLPVLQHARFNHDGTDYLIRYYTTPYSLGDLVYAYMVGDFKHMLLALDITDETCLDPGNYSSYYNFKEQLRNKLASVIPNVNKILAAELPLAITLDNIDLNGFLYDFGDYPTNGKVTNYHVVSCMRQIATFCSLDITQFPSPLGYTVDRPKLQQTLITGSYIDKLLAINALVASNPETPATASTLFIEASAPTTQTAAISNPILGMHVLDWDLIKANHTGVELDLIQTQDPSIYAKPDVLSVGDTIFYYGRRRYKHDAYKRPFYDLDLIQRMNSAGLNLSETTGYHYQCGTTTEAVEDFMYYNYNSPKSFDPSYLKSVYTYMRDKFMKIISTDEKLNHQSGAPRMSSMGVGVSGFFQKTVWNALPEDFSPRLLDTASKTVMPFSTNIVKKFQRQKKTRVRTLGGSSFITSSIFRMLHKPVTNKMVQTAQANIGPFLIGISKFNLGFHKYLSAHHPNGIEDCQVMGADYTKCDRSFPVVCRALSAALFYELGHLEPNNHWFLNEMFAFLLDPSFISGHIFNKPGGTTSGDSTTAFSNSFYNYFVHLYIQYLTFLTTEMPPSYQPLCNLAHQAFSTGNTETYDLYFSMADDLNSTEYFLHFLSDDSFIISKPTAFPIFTPANFSMKLQNVLGCYVDPAKSWSADGEIHEFCSSHICKINEKYQYVPDPNNMLAGLICAPEPTPQDKLIWKLVATCAELAVFHFVNPTLFNNIFHLLQSLHAEFVSEHSVNLLPPKLLEIDFYTDLIDSEDVEQYSFLADTLTEKNIIMQSASQCYFCDNATVSTCSDCTVQYPMCAHCAYEHLMLTDHTPTQVLPCHVCDQTDPRHLNHTFVMGTVKVACDNHVEGMALPLVDHARKLVKIPLYQKCEQQKTSVSAIKYTKLFDENDQPLDPNFFFYDHEQSAEHNYLKILNDCYLLDEHTVQTSTTYDFQCLEGNTIQVFHKPAETFGNTAYAEILDSKGRVVLKVTLDPISAQNPNHYYITTTKGVLYRKYSKIRRTIHKPRLANRHILNTLKKATFIIGPPGTGKTTYVMKNFIDTASPANKVAYIAPTHKLVQSMDQAIWDKYNHTVSVSVVKSELNNNKYNYPLNSATKTIMLGTPGAVCTHAGCTLIFDEVTLSQLNTIINAISVVKPSQVIFLGDPLQLGPVTHMRSLSYSYTNFPLFQFCNDSRVLSICYRCPSNIFNLWVKPYTDSNVRIDPHAAGGDAKIIVSDQCSNPDAYQYVQKLARNNPDKVLLCNYKKPIIGLENAVTIDSSQGKTYKHTIVVLLGNTNFTQVINRAIVAMSRSTHSIEVHCSPFIHTKFSELFGWPQNVEKENQITKQLHEYSVTSNITLLPVSELPNHLGSLVVCDLEFFHVRHETTPKVKCTLEVGEMAIITTSLLKQIIIPRKSAFTAETHHKHTFGVPKGKPDMNWDYMKSHKAISQQINTDRTHKIFSHMAATTLNRVVYVLYGAGNDLRALTNLNIVGDYTCEKCTKEATFYTIHREIVHTFCNHHAPSQFPLMGTINAQAIDIQHASANKQSLTNTHAEVCNQQHGDAHTASADTIMTGCLASNFLMKSAIKLDNILTTSAFKPYAPYIQTGSHLTVSSIKFRTLGTGVFSMIDDKLYHFDILPHHSKLSHFLQHSSNQPHSTIVTEIPAGYPSCVKIKGKGCTFCANTIAVITELYEDLAKLGLTLSRPIIQQAYTQVETQILQNITNVSYNQFGEMLIQLKDDTVIPFINDFQTSIHNYSLRSNQPLPNPAIFKNLGIKATLGFSTPWVPVTTTTTEPHIMSTKILKDNNDYYHLSPVQLKASPHAFSSITAGYYIYTTPMINIPNETPAYYLTHFVHGQSTPLDLGYTSTNRLTTKQFIYTPNEDEYKSKLGHHVSVGDTSNVSWTIGGMHVLTAFQNITNYQLVSGPANPIMRINVALERGNKVETTALDTTLQDYYKIATTNKVTVSKTTFFTLDGGQYRMMNFANPDGTIQTSYPVAQAQSQLITNYRIYPSYITWPTFFTNEATDCWAIPNYNAPPKNQTCNINIQKYDQMCDLFAIDLKIPVKGHIHHLGNAGNKYSPGDVVLRQYFDQAHLTSYDLREVVSDIPVLHPNDEWKAHFILSDVYAPDTDFTSLALEYMQNHLRLGGSIMWKMTETSILQVNEIVKYFGSWKAVTFAVNYSSSETFLFCAGYTGVEYNTSIVQNGYMSLLGGYRKDLLFVPFCNDYTGSKAYKDTGRVKVVANHLADKLTPAHYATASIFLNTALH