wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (P63330)
Organism: Mus musculus (Mouse)
Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (By similarity). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate p53/TP53 (By similarity). Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18084284}. Nucleus {ECO:0000250|UniProtKB:P67775}. Chromosome {ECO:0000250|UniProtKB:P67775}. Chromosome, centromere {ECO:0000269|PubMed:18084284}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P67775}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Centromeric localization requires the presence of SGO2 (PubMed:18084284). Recruited to chromatin and transcription pause-release checkpoint via its association with the Integrator complex (By similarity). {ECO:0000250|UniProtKB:P67775, ECO:0000269|PubMed:18084284}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Immunoglobulin-binding protein 1
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
Sequence:
MDEKLFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Protein: Stimulator of interferon response cGAMP interactor 1 (J3QTB1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000256|ARBA:ARBA00004542}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004542}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004457}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRNLQMTAASRCPRRFSGTCGRRKRKRLLWAA
Protein: ERCC excision repair 8, CSA ubiquitin ligase complex subunit (A0A8I5ZNR2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSIFLCCMCGLW
Protein: RING-type domain-containing protein (Q57YS6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Vacuolar protein sorting 33, putative
- Vacuolar assembly protein vps41, putative
- Pep3/Vps18/deep orange beta-propeller domain-containing protein
- RING-type domain-containing protein
- Vacuolar protein sorting complex subunit, putative
- Ras-related protein Rab-7b
- Vesicle transport v-SNARE N-terminal domain-containing protein
- CNH domain-containing protein
- CNH domain-containing protein
- Ras-related protein rab-5
Sequence:
MAAVWRSFKFFNAELVKNPLCRMEMTCCCCGEGLVFAGGSDGAVWAVDRSSNNEGVKCEFGAYKGPVLYMKYVQSRNVLVTIGDDDGEDVCVIRVWNLEAAAAPGRISPPPCNEHRLFSSKHPPPRERVPLCPIYDTGSTSSPTSNKRRDATDCAPTTSINTVVASFDVADDLQCMAVALVSGDVILLHDDLERKKALRLQRLRSNIAKGPIAFVGFTRATYTPDATTKKTKNQQLFTLSASRRGEEMVTHIMYSVYADCVTVWQVSSAGCEEHSCDSFGGALRGRCCMTDDGQLVVASNASDHITVFGNKETLSPRKQSQGSFVSSHFSSSQAVEVAGRKCLLLSHRGYVVVLAQSDAWSDRFVLQCYDLPNRLRCLSRSQENYCTHVEWMLADSSDILVFCREPIRHVEASNSGSVTGYESKNIRTAAHACYQVVRLVEVGLEKRLQQLFQKECYEIAQSIACRSQSTPGGRHRKNQQLLDIKKHYGDYLVSKRDYTGAMRQYVDIIGHVEPSYVIRVFVDAQQIVPLTGYLEELHNTRDNQTAQRSHTTLLLCCYIQLHDEEKLNNFIRRSDVRFDPRIAIDVCTEARYYEAALYLAEKYAKPHDYVTVQLDHLNNPKKALEFIQALCLDDAEAILRQQHGKHLVAALPRRATEVLINLCVGWSGPARRLVGNEVATSKEGGPKHHNRGDAKDFLHILSDFPVCLLHFLRAVVNSGVLDDADPKREMVIYNTLLEMYVTRELKHATRGNIIPMEEESFVAESCEERRKQAYGFFTVHSGRYDPYHALLLAEQHGFEEGVFVLLRRLNCSTELMQYHAKGLAHGVPTLVRQIAKTRLIEICLNSTNDGVEQSNDGSGNGPKSGGSARELWLSLLSMLAHTPESDAQDISQVLGHIAAQDALSPLSVLTTLNSSNPELPLHIFRDYVVRMVQREVKRSESIKARTEARLKELHELHGKLDALQTRVTTLQAFNCNHCGSPLDLPAVYFSCQHAFHQRCLNDTARCNVCSPANFEFGCVDQPQYDGEDESDKFFHCLGGFSYEKGFDVVVERFSNGVTGLQGPRKMDAPCDSSSIVHGLLNSSIDLTSSVNRSRGPSETVLLSDDDTYDESGELMKPEAVELW
Protein: Exosome complex component RRP41-like (Protein SLOWER GROWTH) (Ribosomal RNA-processing protein 41-like) (A2RVK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is a processive phosphorolytic exonuclease and requires a single-stranded poly(A) tail on the substrate RNA for its activity (By similarity). Plays an important role in seed germination and early seedling growth by mediating specific cytoplasmic mRNA decay of transcripts coding for the abscisic acid (ABA) biosynthetic enzymes NCED5 and NCED6, and the ABA signaling transcription factors ABI3 and ABI4.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23132787}. Nucleus {ECO:0000269|PubMed:23132787}.
Interaction partners:
- Exosome complex component RRP4 homolog
- Ribosomal RNA-processing protein 42
- Exosome complex component RRP41 homolog
- Exosome complex component RRP45A
- Ribosomal RNA-processing protein 43
- Exosome complex component RRP45B
- Exosome complex exonuclease RRP44 homolog A
- Nuclear nucleic acid-binding protein C1D
- Inactive exonuclease DIS3L2
- Ribonuclease II, chloroplastic/mitochondrial
Sequence:
MAAKPGAATPTYSPKIVGRSRLPIFKDSDLDWSRPDGRGFHQCRPALLQTGAVSSASGSAYAEFGNTKVIVSVFGPRESKKAMVYSDVGRLNCNVSYTNFASPTLGQGTDHKEYSSMLHKALEGVIMMETFPKTTVDVFALVLESGGSDLSVLISCASLALADAGIMMYDLITAVSVSCIGKSLMIDPVTEEEGCEDGSFMMTCMPSRYEITQLTITGEWTTPNINEAMQLCLDASSKLGEIMRDCLKQSASASDE
Protein: SET domain-containing protein (Q57WV8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRLRGQQQFLFSPAVGGQCSAALRCVHVTFSPKVPLVTSPLSTAARFFARVSPIQGTIDSPNDGFVTKDVKIDINPNIGGAYARGVFARREIGYGREIMNIPAFVMYISDSSNQSLRDQVLVVTKQIFSKLVLGTPEEQHYIKHRVATLMSGGYSYFTRERDVFEFAEEVRVPGPEGVLKNGASYLLSGEFSSYDLQKLPLIVEFNRYDVEYRGRRGICLFPEAQYFNHQCQPNVEVTITYNNLKSNFYLSARTIRPVREGEELFIDYMPGNTMPLSRLALAMKKRWGFECTCVRCKSRGIGAVMFLFVVVLIPMVAYLRSVNVRRVQNKQRGV
Protein: Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6) (Q64731)
Organism: Mus musculus (Mouse)
Function: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q12952}.
Interaction partners:
Sequence:
MSHLFSPPLAALAASPLLYVYSPERPGLPLAFAPAAALAGPGRVEPPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNECFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPAAGSPEAKRTRVEPPESEVGCDVGSPDLATALPTRAPDRSQSPAVGTARPALLPWPGPEPRDPDADLTVQGAGAVASGQLQRPAHHLGSPLCPAPSGSPKGSKSKSFSIDSILAVRPTPASGAEAPGIPKPVPGALGSSLLAASSGLAPPFNASLVFDAHVQGGFSQLGIPFLSYFPLQVPEATVLRFH
Protein: CDK5RAP3 protein homolog (Q95SK3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable regulator of cell proliferation. May regulate CDK5, NF-kappa-B-mediated gene transcription and p53/TP53 activation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96JB5}. Cytoplasm {ECO:0000250|UniProtKB:Q96JB5}.
Interaction partners:
- DDRGK domain-containing protein 1
- E3 UFM1-protein ligase 1 homolog
Sequence:
MNESEIPIDIHTLKLQDWLISRRIVPKNVQQELREIHRKISNALQDMPSNEQLIKLLARTNINYYHVKEIIEILKQTEKDTKSVFGTYGSQRMKDWQEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQMARLEQQADETQKRAHDLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLPELYDKSLVGIANIQPGIDLYAEVSGNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEGNASKDDNAVAEIDFGTDDNGGTSSTVSAEIIDYGDFGSGDLPESDGGNIDWGIESAPTDAVEINFDIPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMRIYELKQLESSSDIMFSLMDNIATHDGESIWKILVSVEKIIQQTSDKQTQHLFQLKHSPKYANMLATKLQQMTKAVEKLRATREALKQLTIELREQRQDLNPVLEELIAQTRTLQSHIEKDISKRYKNRVVNLMGGVN
Protein: Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1) (Q8BHK3)
Organism: Mus musculus (Mouse)
Function: Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11959859, ECO:0000269|PubMed:14600155}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14600155}. Recycling endosome membrane {ECO:0000269|PubMed:14600155}.
Interaction partners:
- Sodium-dependent neutral amino acid transporter B
Sequence:
MSVTKSARSPQVATPLNLDLPESAKKLQSQDPSPANGSSSESSKKTKGITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQRFCHRLNKPFMDYGDTVMHGLAFSPNAWLQNHAHWGRRVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTISCHKNETVVLTPTMDSRLYMLSFLPVLGLLVFVRNLRVLTIFSLLANISMLVSLVIIAQYIIQEIPDASQLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKDARGFPTILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPNCWLYQSVKLLYVVGILCTYALQFYVPAEIIIPLAVSQVSKRWALPVDLSIRLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVVTYYGEGISPLTVTKDALISILGFMGFVVGTYQALDELIKSGNSPALSNSTMFIQ
Protein: Estrogen-related receptor splice variant (Estrogen-related receptor, isoform B) (Q8WS79)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002527}.
Interaction partners:
- Connector of kinase to AP-1, isoform E
- Taiman, isoform G
- Cytosolic Prostaglandin E synthase
- FK506-binding protein 59
- Epidermal growth factor receptor
- Nuclear hormone receptor HR96
- Smrter, isoform G
- Palmitoyltransferase
- Superoxide dismutase
- type I protein arginine methyltransferase
Sequence:
MKFYAGEGQGTNMSDGVSILHIKQEVDTPSASCFSPSSKSTATQSGTNGLKSSPSVSPERQLCSSTTSLSCDLHNVSLSNDGDSLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKALLLANCDILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQQLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLEPLAR
Protein: Adaptor protein complex 2, mu subunit, isoform A (Adaptor protein complex 2, mu subunit, isoform B) (Adaptor protein complex 2, mu subunit, isoform C) (Clathrin-associated adaptor complex AP-2 medium chain) (Clathrin-associated protein) (SD05403p) (O62530)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane, coated pit {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004277}.
Interaction partners:
- AP-2 complex subunit alpha
- AP complex subunit sigma
- AP complex subunit beta
- Clathrin heavy chain
- AP-1 complex subunit gamma
- NECAP-like protein CG9132
- AT02057p
- AP-3 complex subunit delta
- Mucin 12Ea
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
Sequence:
MIGGLFVYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHIKRANIWLAAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSGTLKTFITQQGIKSATKEEQMQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQVLSAHVAGKVVMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPVVVIDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTKMEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGMKETQLSAEIELLETDTKKKWTRPPISMNFEVPFAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIGRSGLYETRC
Protein: Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2) (Q8WXH6)
Organism: Homo sapiens (Human)
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Cullin-5
- Elongin-C
- Ras-related protein Rab-40A-like
- PSME3-interacting protein
Sequence:
MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRMNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPSTLRSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKSSLCKVEIVCPPQSPPKNCTRNSCKIS
Protein: Uncharacterized protein (Q38BD8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFVSDNDDYLPEPQAPGDHHMHEERLRRLEENFALLLNQRSVGNASGPKESTPKARVTAVAADVQAADERSLKLTYELRELVPHLSPGFDCCSADALLLLSAIRNGSHGRGCESWEDRLAVVKAEKRSLHHQLEKKAQECEELKNAVAEMKQRLKAERQEALSSVNVLSQRREQVRKQLLLEESRSQKLQVRNGQLESELERLKDMLHSCMRR
Protein: Brevinin-2Ec (P86151)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:18280749, ECO:0000269|PubMed:18855342}.
Interaction partners:
Sequence:
GILLDKLKNFAKTAGKGVLQSLLNTASCKLSGQC
Protein: Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-phi member 1) (GST-29) (GST-I) (P12653)
Organism: Zea mays (Maize)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides.
Interaction partners:
- methionine--tRNA ligase
- methionine--tRNA ligase
- methionine--tRNA ligase
- Glutathione reductase
- Dehydroascorbate reductase
- Glutathione peroxidase
- Glutathione peroxidase
- Glutathione peroxidase
- Glutathione peroxidase
- Glutathione peroxidase
Sequence:
MAPMKLYGAVMSWNLTRCATALEEAGSDYEIVPINFATAEHKSPEHLVRNPFGQVPALQDGDLYLFESRAICKYAARKNKPELLREGNLEEAAMVDVWIEVEANQYTAALNPILFQVLISPMLGGTTDQKVVDENLEKLKKVLEVYEARLTKCKYLAGDFLSLADLNHVSVTLCLFATPYASVLDAYPHVKAWWSGLMERPSVQKVAALMKPSA
Protein: glutathione transferase (EC 2.5.1.18) (Q9SM20)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MAPLKLYGMPLSPNVVRVATVLNEKGLDFEIVPVDLTTGAHKQPDFLALNPFGQIPALVDGDEVLFESRAINRYIASKYASEGTDLLPATASAAKLEVWLEVESHHFYPNASPLVFQLLVRPLLGGAPDAAVVEKHAEQLAKVLDVYEAHLARNKYLAGDEFTLADANHASYLLYLSKTPKAGLVAARPHVKAWWEAIAARPAFQKTVAAIPLPPPPSSSA
Protein: Ribosome biogenesis protein YTM1 (Q5APF0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
Interaction partners:
- Ribosome biogenesis protein NSA1
- Ribosome biogenesis protein ERB1
- Pescadillo homolog
- ATP-dependent RNA helicase HAS1
- 60S ribosome subunit biogenesis protein NIP7
- rRNA-binding ribosome biosynthesis protein
- Cic1p
- rRNA-binding ribosome biosynthesis protein
- Csi2p
- mRNA-binding ribosome synthesis protein
Sequence:
MSSTGENKNQIKIKFFTNEEDESLQVADTPLYVPVTLKRFGLSEVVNHLLGNFKGEDETKAPIPFDFLIDGVLLRTSIEDYLTKNGLSNEAFLTLEYTRAILPPSFLASFNNDDWISSIDSINPTTKIVMSSQLSISQPKILSGSYDGIVRTYNMSGKVEKQYVGHSAPVKAVKWISPTRIVSAGNDRQVRLWKTSYEEIIDEDEEEIEDGKTLALLEGHKAPVVDLAVDTQTNRILSAGYDQNIGFWSTNYKEMTSIQPLEYDSNVVSSSSKKRRKMAVQDATIRRRAPLSLLQGHSEPVEGVIFDAKDSTVGYSVSQDHTIKTWDLVTSRCVDTRTTGYSLLSVLQLPQVNLIASGSSARHINLHDPRVTTTSDQTISKLVGHTNFVVGLTASPHNQNMFASSSHDGTVKVWDVRAEKSLYTITRQDGSTNAKIFDVCWDDRIGIISGGEDKKLQINKGSDIAK
Protein: UBP1-associated proteins 1A (UBP1-interacting protein 1a) (Q9SHZ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as component of a complex regulating the turnover of mRNAs in the nucleus. Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs. May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus. However, unlike UBP1, UBA1A does not stimulate pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:12024044}.
Interaction partners:
- Probable LRR receptor-like serine/threonine-protein kinase At1g51810
- Carboxyl-terminal proteinase-like protein
- Uncharacterized protein T14D3.50
- Probable serine protease EDA2
- Ubiquitin carboxyl-terminal hydrolase 1
- Pathogenesis-related thaumatin superfamily protein
- DGCR14-like protein
- Probable disease resistance protein At1g63360
- Putative disease resistance protein At1g63350
- Probable lysophospholipase BODYGUARD 2
Sequence:
MAKTLDKSKKRKLVKSKSTNFDKKQKINKQQQQPESSTPYSSSSSSSDSSDSESDNEFDPEELRELLQPYSKDQLVDLVCSASRIGSSIYSAVVEAADRDVTHRKIFVYGLPWETTRETLVGVFEGYGEIEECTVVIDKATGKAKGFGFVMFKTRKGAKEALKEPKKRILNRTATCQLASMGPAASGKGHDQPGPVKISMGSMANHGQPQQQQVQGQHVFNGGGMAASPFMLGNQYHPLYGAGMLGNPALAAAAAAGGGYMYPMLAGALAHGGLGSDMVQSSQMGGIGVDPSVGAAGLSALGSYFRGQSLPSTYPDSDAGGKRGTGKDSDAGGSSFHGYSNYS
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-) (Q9UKP5)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Furin
Sequence:
MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
Protein: Dynein axonemal assembly factor 19 (Coiled-coil domain-containing protein 103) (Q8IW40)
Organism: Homo sapiens (Human)
Function: Dynein-attachment factor required for cilia motility.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6DGB6}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q6DGB6}.
Interaction partners:
- Dynein axonemal intermediate chain 2
- Dynein axonemal intermediate chain 1
- Outer dynein arm-docking complex subunit 1
- Dynein regulatory complex protein 1
- Dynein axonemal heavy chain 5
- Dynein axonemal assembly factor 3
- Dynein axonemal assembly factor 11
- Dynein axonemal assembly factor 1
- Dynein regulatory complex subunit 2
- Coiled-coil domain-containing protein 40
Sequence:
MERNDIINFKALEKELQAALTADEKYKRENAAKLRAVEQRVASYEEFRGIVLASHLKPLERKDKMGGKRTVPWNCHTIQGRTFQDVATEISPEKAPLQPETSADFYRDWRRHLPSGPERYQALLQLGGPRLGCLFQTDVGFGLLGELLVALADHVGPADRAAVLGILCSLASTGRFTLNLSLLSRAERESCKGLFQKLQAMGNPRSVKEGLSWEEQGLEEQSGGLQEEERLLQELLELYQVD
Protein: Platelet-derived growth factor receptor-like protein (D6RG11)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETP
Protein: Mitochondrial thiamine diphosphate carrier 2 (A0A1D6N272)
Organism: Zea mays (Maize)
Function: Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:22426856}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGSGEEPSQMRRALVDSLAGAISGGISRTVTSPLDVIKIRFQVQLEPTTSWGILRRDIYGPSKYTGLLQATKDILREEGLPGFWRGNVPALLMYMPYTAIQFTVLHKLKTFASGSSKTEDHLHLSPYLSYVSGALAGCAATIGSYPFDLLRTILASQGEPKIYPNMRSAFVDIIKTRGVQGLYSGLSPTLVEIIPYAGLQFGSYDTFKRSMMTWNRYKYSHLNFGSEDDSVSSFQLFLCGFAAGTFSKAACHPLDVVKKRFQIEGLKRHPRYGARIESSTYKGMYHALKEIVAKEGFGGLYKGLFPSLVKSAPAGAVTFVAYEYISDWIGSKAGVE
Protein: CD4-like protein 2 (Q1W650)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
MFRSKNILWITFAFCLTSGSCTDIFQQSGSDAKMDCSGGDPKKAIEWKRGNVLLIGKAPSGTVRRGIMETTSRARIDGTTLKITQLKTSDNGVYTCNSYTYKLYVVSASANPSSVLYSSETTLSCDVAGDFKGTFQWLESGSKPYSQSREVTVKNVTSDTARIWTCLIKNEKSKEIIRLDVNIGVVGPLNTPREVKTHEGGSAVLPCFLPTKSQLPITGGSWKRESHSDIRFPVLMRKQNAVQWNSTDVSIDKVTFTEQEVMTNFSVTLKKVKVADAGVYVCSLKFENGKALTSSLNLTVSKRDGDDPDMDSRGSTVTKNNMWNKRVWGMQLWVWIAVSASSFVLIGLVVIILLIHCRNKRMKKKMMKLKSMRQPHTSRNYCKCDRPVSQAGTGKRGRPPPLPRHQYSSLNE