wanglab/gogpt-training-data huggingface dataset:
Protein: Protein Wnt-4 (P22724)
Organism: Mus musculus (Mouse)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-3
- Frizzled-6
- Frizzled-4
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-9
- Frizzled-2
- Wnt inhibitory factor 1
- Frizzled-1
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-8
Sequence:
MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDIRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCGCRFHWCCFVKCRQCQRLVEMHTCR
Protein: ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1) (Q80T21)
Organism: Mus musculus (Mouse)
Function: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Colocalizes with FMN1 microfibrils in the eye ECM. {ECO:0000250}.
Interaction partners:
- Fibrillin-1
Sequence:
MESWLGRLWLCMMLLLPLPQPCQDQELFGPSHQLPSEEGQVPEGLWGPWGRWASCSQPCGVGVQRRSRTCELHPALPLPPRPPRHPEAHRPRGQGSRPQTPRDPQSLYRPQPRGRGGPLRAPASQVGREETQEPQGAQRFRVRDPIKPGMFGYGRVPFALPLHRSRRHPHRPGQPKNSSTGEGMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTSSFGDSRSFQGSLGPRMPPSPGSWSSPQGAERRHPPPFSPVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSPLWSIFAPSIPAPNCSGESEQMRACSQEPCPPEQPDPRALQCAAFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGSLDICVAGRCLSPGCDGVLGSGRRPDGCGVCGGDGSTCRLVSGNLTDRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYTAIGTVFQYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEDNPGVFYQYVISSPPAVLESPSTKPPALQPQPEMLRGEPLLPSAPRPVRAPGTLQRQVRIPQVPPPTRVRTAMGSSAGYWKQVGHSECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASPEPCHGPPCPPYWEAGEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQPCQLHLCGHWEISSPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREACDMGPCTTAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLRSRPPDMRACSLGPCERTWRWFTGPWSECSSECGSGTQHRDIICVSKLGAEFNVTSPSNCSHLPRPPALQPCQGQACEDKWFSTLWSPCSRSCQGGMQTREVQCLSGNQTLSSRCPPHLRPSRKRPCNSQPCNQRPDDQCKDSSPHCPLVVQARLCVYPYYTTTCCRSCAHVLEQSQLEPA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (C0H514)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Protein phosphatase PPM5, putative
Sequence:
MKFIGVLFLFLLNVIIYETNIILNDKIFERYNRSLSVFIRDNNKDEEGTKELLLRKIEKEEEVYDLKDVRNDYMNDSIKDNNNHSTNDYLKGTTTDSTKFHIYDNIKCTLQYDKNDSTKNVIYDSTNTTVIEDSNGKKNNDEGDYSLCNKKKKKRRKKKIEMKDNNNNNNSINNNNLYDEKTENVQIEKVVNRPPYVDIAKSLNEDDNVSNNSYDNFDMKTNIISDLEQEIKNKCIFNWDIGKETLLKMFDMSENFEINDVNYESWILHKVPTKNYSERSGRVQEMFKVVINSKDGSGNDIRLFVKKIPIKVWVKQYNLMKKYNGEYVFGSENFIMEAMALSFLTEYYPGIAPKLYKVLIEPDNIYYYKGITKEKMFDNMNTLNEILSKGIKDDINGNIVIVSELFGKDIKKFLFTENENILAIIDNNNKKKYLIESLKLLVRLHEAGLAHLDFTPENILIKKNGGMRLCDFGKSTPVYSYNLRHIKNENGLCYFESCIPSIGKVAYIPPECWEIKKLHKTEKIRNPYTSLRNITDQGERKRFYFDVLAADKFMVATFFIWLWNEGHLWDKATASQDEIFFKIVEKGMNLKALELTRKWPRELKSIIKNLISLESRKSFNLKDLIDHPWFTNK
Protein: Pentatricopeptide repeat-containing protein 1, mitochondrial (A2VD13)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:19651879}.
Interaction partners:
- FAST kinase domain-containing protein 2
- Pseudouridylate synthase RPUSD4, mitochondrial
- Mitochondrial ribonuclease P catalytic subunit
- Small ribosomal subunit protein mS39
- Transcription termination factor 3, mitochondrial
Sequence:
MDLLRLSRLFSGPHPIGLSVLQRLDLLRSTQWTGGREGPAWLRAASCSSSSHQKRMSSLCSDSSTPVAPQEEEEEESFGTLSEKFSSRRIFHKSTAQLYNLKLKEQGVEEEELEPRLRQGGRNTPYWYFLQCKRLLKEGKLAEALDLFERQMLKEERLQPLECNYTVLIGGCGRVGYLKKAFRLFNDMKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAQNFQLNLKTYHALLKVAAKCADLRVCLEVFKEIIQKGHAVTEETFCFLLMGCIQDKKTGFRQAMQVWRQMLSLGIKPSRHGYNLLLGAARDCGLGDPEVASRLLLTSQEETILLQPPTGRRLAGGKVQAKTRHGVSVKHVEALERQLFLEPSHKLEGPPAFPEARETSRTQPEVETKAEPGHMGALAPLALKPPDLELQVNLLSLGALSPAVVSFGTVATPADRLALMGGLEGFLGKMAEHRLQPDIKTLTLLAEVVEPGSPAESSLLSILDRHRVEADITFFNTLIRKKSKLGDLEGAKALLPILAKKGIVPNLRTFCNLAIGCHRPRDGMQLLADMKKSQVTPNTHIYSTLINAALKKLDYTYLISILKDMRRNSVPVNEVVIRQLEFAAQYPPTFDRYKEKNTYLEKIDGFRAYYKQWLKVMPAEEPPHPWQEFRDKPVRNQVITENAGGLRDG
Protein: Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) (O70318)
Organism: Mus musculus (Mouse)
Function: Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O43491}. Cell membrane {ECO:0000250|UniProtKB:O43491}.
Interaction partners:
- COP9 signalosome complex subunit 1
- Tropomodulin-1
- Brain acid soluble protein 1
- Myosin-9
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 2
- Cell adhesion molecule 1
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 4
Sequence:
MTTEVGSASEVKKGSDQAGADASKEKAKEVENEQTPVSEPEEEKGSQPGPPVERQSTPRLRKRGKDPSENRGISRFIPPWLKKQRSYNLVVAKDGGDKKEPTQADVEDQILGKEESLPEEESRAKGDAEEMAQRKHLEVQVEVREAKPALKSSVETQPAEEVRKDKEETIQDTQEEKLEGGAAKRETKEVQTSELKAEVASQKATKKTKTVLAKVTLLDGTEYSCDLEKRAKGQVLFDRVCEHLNLLEKDYFGLLFQDHPEQKNWLDPAKEIKRQLKNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEHGDYDPEEYDSIDLGDFQFAPAHTKELEEKVSELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTKFLTLGSKFRYSGRTQAQTREASTLIDRPAPQFERASSKRVSRSLDGAPIGVVDQSPPGEGSVPGPGVISYTTIQDGRRDSKSPTKATPLPAEGKKNTLRVDGDNIYVRHSNLMLEDLDKAQEAILKHQASISELKRNFMASTPEPRPSEWEKRRVTPLPFQPQASSHETLNVVEEKKRAEVGKDESVITEEMNGKEMSPGHGPGETRKVEPVAHKDSTSLSSESSSSSSESEEDVGEYQPHHRVTEGTIREEQEECDEELEEEPGQGAKVVEREAAVPDAVPDRQAGASVLPVETEAQEHVVAQKLPGEKGAHGGTAEQDPREEAEEDPHRVNGEVPHLDLDGLPEIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTITYESPQIDGGAGGDSGVLLTAQTITSESASTTTTTHITKTVKGGISETRIEKRIVITGDAALDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGEE
Protein: Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha] (P06302)
Organism: Rattus norvegicus (Rat)
Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular location: Nucleus.
Interaction partners:
- Kelch-like ECH-associated protein 1
- Parathymosin
- Sodium-dependent proline transporter
- Small ribosomal subunit protein uS3
Sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVETKKQKKTDEDD
Protein: Thymosin beta-15B (P0CG35)
Organism: Homo sapiens (Human)
Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62328}.
Interaction partners:
Sequence:
MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQTS
Protein: FMRFamide-like neuropeptides 11 [Cleaved into: AMRNALVRF-amide; ASGGMRNALVRF-amide; SPLDEEDFAPESPLQ-amide; NGAPQPFVRF-amide] (Q21156)
Organism: Caenorhabditis elegans
Function: FMRFamides and FMRFamide-like peptides are neuropeptides.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 24
- FMRFamide-like neuropeptides 1
- FMRFamide-like neuropeptides 13
- FMRFamide-like neuropeptide 18
- FMRFamide-like neuropeptides 9
- FMRFamide-like neuropeptides 14
- FMRFamide-like neuropeptides 7
- Neuropeptide-like protein nlp-8
- G-protein coupled receptors family 1 profile domain-containing protein
Sequence:
MTQFSALALLLIVFVAASFAQSYDDVSAEKRAMRNALVRFGRASGGMRNALVRFGKRSPLDEEDFAPESPLQGKRNGAPQPFVRFGRSGQLDHMHDLLSTLQKLKFANNK
Protein: Diuretic hormone 44 receptor 1 (A1Z9Q8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Diuretic hormone 44, isoform A
- Diuretic hormone receptor
- Protein hugin
- G protein alpha s subunit subunit alpha)
- G protein beta subunit 5
- Guanine nucleotide-binding protein subunit beta-1
- Pyrokinin-1 receptor
Sequence:
MSDHNHIDSVNASGSDPLLDLHNLDGIGESVELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEKYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSVQISIRSGVGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTTLVGQHAPLSLHRGSNNALHTMPTLAANAMSSGSTLSVMPRAISPLMRQGLEENSV
Protein: Vacuolar sorting protein 39 (Protein EMBRYO DEFECTIVE 2754) (Q8L5Y0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis. Believed to act in part as a component of the putative HOPS endosomal tethering complex. HOPS is required for the central vacuole formation. May play a role in clustering and fusion of late endosomes and lysosomes. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29463724}. Vacuole membrane {ECO:0000269|PubMed:29463724}; Peripheral membrane protein {ECO:0000269|PubMed:29463724}; Cytoplasmic side {ECO:0000305}. Note=Co-localizes with VPS18 and RABG3F at subdomains of the vacuolar membrane with a small number of punctate structures in the cytoplasm. Sometimes observed at the vertex zone, the ring-shaped edge of vacuole-vacuole contact sites. Strong colocalization with VAMP713 at the contact sites of two vacuoles. {ECO:0000269|PubMed:29463724}.
Interaction partners:
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar sorting protein 18
- Protein VACUOLELESS1
- Vacuolar protein-sorting-associated protein 33 homolog
- Transducin family protein / WD-40 repeat family protein
- Vacuolar fusion protein CCZ1 homolog A
- Vesicle-associated membrane protein 713
- Syntaxin-22
- Vacuolar protein sorting-associated protein 45 homolog
Sequence:
MVHNAYDSFQLLKDCPARIDAVESYGSKLFAGCYDGSLRIYSPPESSASDPSELHQETYVLEKTVAGFSKKPIVAMEVLASRELLLSLSESIAFHGLPNLETVAVITKAKGANAYSWDDRRGFLCFSRQKRVCVFKHDGGGGFVEVRDYGVPDTVKSISWCGENICLGIKKEYVILNTANGTLSEVFPSGRVAPPLVISLPSGELILGKENIGVFVDQNGKLLQTERICWSEAPTSIVIQNPYAIALLPRRVEVRLLRSPYPLIQTIVLQNIRRLVKSNNAVIVGLDNSVYVLFPVSIGAQIVQLTASGNFEEALALCKVLPPDESSLRAAKESSIHTRFAHYLFENGSYEEAMEHFLASQVDITHVLSMYPSIILPKTTIIPQPDKMVDISGDEASLSRGSSGISDDMESSSPRYFLESEDNADLESKKMSHNTLMALIKYLLKRRPAVIEKATSEGTEEVISDAVGKTYGANDSSKSKKSSKGRGMIPLNSGAREMAAILDTALLQALLHTGQSGAAIELLKGVNYSDVKICEEILMKSKNYSALLELFKSNSMHHEALKLLNQLADESKTNQSQTDVTQIFSPELIIEYLKPLCRTDPMLVLEYSMLVLESCPTQTIDLFLSGNISADLVNSYLKQHAPNMQGRYLELMMAMNDTAVSGNLQNEMVQIYLSEVLDLYAAKSAQQKWDEKDHPPERKKLLSALESISGYSPQPLLKRLPRDALYEERAVILGKMNQHELALSIYVHKLHAPDLALAYCDRIYESVTYLPSGKPSSNIYLTVLQIYLNPKKSAKDFAKRIVALGSFESSDTTKMMDSVLSSKAKGGRSKKIVAIEGAEDMRVGLSSSTDSGRSDVDTEEPLEEGDSTVMISEVLDLLSQRWERINGAQALKLLPRETKLHNLLPFLAPLLRNSSEAHRNFSVIKSLRQSENLQVKEELYKHRKGVAQVTSESMCSLCNKKIGTSVFAVYPNGKTLVHFVCFRDSQGMKAVSKTTHGRRR
Protein: Alpha-(1->3)-arabinofuranosyltransferase (EC 2.4.2.47) (Arabinofuranan 3-O-arabinosyltransferase) (P96419)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-
- Probable conserved transmembrane protein
- Terminal beta-
- Galactan 5-O-arabinofuranosyltransferase
- Polyprenol-phosphate-mannose-dependent alpha-
- Probable conserved membrane protein
- Uncharacterized methyltransferase Rv0224c
- Polyprenol-phosphate-mannose-dependent alpha-
- Probable conserved transmembrane protein
- Uncharacterized protein Rv0955
Sequence:
MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFLARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFWGLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILALRGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWLLAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNATAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLASPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAFAHPERDKRVAVAVVALTALMVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAATPTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRLFAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFGAPVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLRLDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAPGDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGDPATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTLRFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQLRHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLTVPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAWTAPQRVVQHKTPPTLTLTLPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQVGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLSAGGAPIAPADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALPAGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRVLVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLAIGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGTALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALISVSVVAASVVATSESRGQDRMQ
Protein: 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) (P00973)
Organism: Homo sapiens (Human)
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689, ECO:0000269|PubMed:3754863}. Mitochondrion {ECO:0000269|PubMed:19923450}. Nucleus {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689}. Microsome {ECO:0000269|PubMed:19923450}. Endoplasmic reticulum {ECO:0000269|PubMed:19923450}. Secreted {ECO:0000250|UniProtKB:Q29599}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000269|PubMed:19923450}.; SUBCELLULAR LOCATION: [Isoform p46]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, prenylated form localizes to membranous perinuclear structures reminiscent of the endoplasmic reticulum rich in viral dsRNA which are SARS-CoV-2 replicative organelles. {ECO:0000269|PubMed:34581622}.; SUBCELLULAR LOCATION: [Isoform p42]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.
Interaction partners:
- 2'-5'-oligoadenylate synthase 2
- 2'-5'-oligoadenylate synthase 3
- Interferon-induced GTP-binding protein Mx1
- Ubiquitin-like protein ISG15
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Signal transducer and activator of transcription 1-alpha/beta
- 2-5A-dependent ribonuclease
- Interferon-induced protein 44
- Ubl carboxyl-terminal hydrolase 18
- Antiviral innate immune response effector IFIT1
Sequence:
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
Protein: At1g07030 (Mitochondrial carrier protein, putative) (Mitochondrial substrate carrier family protein) (Q8L6Z2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Asparagine--tRNA ligase, cytoplasmic 3
- Asparagine--tRNA ligase, cytoplasmic 1
- Asparagine--tRNA ligase, chloroplastic/mitochondrial
- Phosphatidylinositol-3-phosphatase myotubularin-1
Sequence:
MATEATTVPKFQEPDLRQVSQTPDFKPEIAHDGLKFWQFMIAGSIAGSVEHMAMFPVDTIKTHMQALRPCPLKPVGIREAFRSIIQKEGPSALYRGIWAMGLGAGPAHAVYFSFYEVSKKYLSAGDQNNSVAHAMSGVFATISSDAVFTPMDMVKQRLQMGEGTYKGVWDCVKRVLREEGIGAFYASYRTTVLMNAPFTAVHFATYEAAKKGLMEFSPDRISDEEGWLVHATAGAAAGGLAAAVTTPLDVVKTQLQCQGVCGCDRFTSSSISHVLRTIVKKDGYRGLLRGWLPRMLFHAPAAAICWSTYEGVKSFFQDFNVDSNTA
Protein: Parvalbumin alpha (P32848)
Organism: Mus musculus (Mouse)
Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Interaction partners:
- Somatostatin
- Calretinin
- Calbindin
- Glutamate decarboxylase 1
- Methyl-CpG-binding protein 2
- 45 kDa calcium-binding protein
- Pro-neuropeptide Y
- Glutamate decarboxylase 2
- Neurotrophic factor BDNF precursor form
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Sequence:
MSMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES
Protein: Uncharacterized protein YEL043W (P32618)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Protein NNF2
- Uncharacterized protein YFR035C
- Bud emergence protein 1
Sequence:
MPVSVITTVLACLWLSYRLYKFLTIPVSSIVSTLKIKTPPATKVSIDKIATDSVTIHWENEPVKAEDNGSADRNFISHYLLYLNNTQLAIFPNNPNSLYTCCSITGLEAETQYQLDFITINNKGFINKLPSIYCMTKAREANEALKTRKWRRNTITSSTAMQPRNSKSEPAPLPSHYSSVSLSTFSSNITNSATSNNGSNLPAYTSLTTLKDLDSFSIDDLKKILICAQEDLHDVLSQQTSLLQDFQESKLELELELDNLKTHWSHEIDLRKSLKSNIKSLENSKLLTDLKIEKLNKKIDKSKEKISKMRNDMQKWSQEDTELLSKDTIKEKYFKLLNESNASVANINKEIESLQNEISKMEESNKRLNASKKSLITSIVVNANVENDKPIASGELSAVLKKLNDFTLEKNGFLSNAGEEFLSKLNADSSLIKMIKQELSIDQELEANWKLQRSNLLKKISALENQFNEMSLNNRNLKTKLMVQPYKNNGDSLAATNSNNSAEKNRSSGSIQLPLSNNMSRTGSIDLISNNNKSINNSNADSAPPLRLHNPVSYSPSNEPIQPSSSLLSQLTQDTDNRSMLSNHISSNNENKQQPSSYSHALPTTATANATATATATNGHSRSNLWTTAQFAQPSHQQVSTELDQAFEYDNANHLISGLQNMIYDETDYPDNISNYSKGFTTDELDNYWTKQQPQVRSTNESLFSTTGTPMSSYKANPVISPYSSSHLRQTSNATNTNPMHPQSLLAATLNDPSLQSFVRSGSFYSAPQPANSLQNNINGNETENISPRISSDFNLLVPNLSPRLSNDVPIVPGNNTTLTPSHSNILTMNHQPTADNITRRSFHASSPPFNSIWNSNTNQLSPPLEEQYHLDVPVGPKVPAKEPSPKPSHKRNQSNSSISSAWSKFKHKSASSPANADTDIQDSSTPSTSPSGRRMSKLLSKSGMNNLFNPHSHDS
Protein: Trinucleotide repeat containing adaptor 6B (F1LV37)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- WD40 repeat domain 95
- Uncharacterized protein.
Sequence:
MHTNEGEVEEESSSQVEQEDFVMEGHGKTPPPGEESKQEKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGPPPCTAPGANPNNAQVTGALLQSESGTAPESTLGGAAASNYANSTWGPGASSNNGASPNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSALPGSTTSNKGKGSQCQSASSGNECNLGVWKSDPKAKSVQSPNSTSDSNNGLGTWRSTSGQDRIGPGSGFSNFNPNSNPSAWPALVQEGTCRKGVLEAEGSSSSAQVSTVGQASREQQSKMENAGVNFVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTGSVGSWGAARGPSGADTVSGQSNSGNNGNNGKDREDSWKGASVPKPTGSQSDSWDNNNRSTGGSWNFGPQDSNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSAGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPAHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKSTGGWNDYKNNNSSNWGGGRADEKTPSSWNESSCKDQGWGGGRQPNQGWTSGKNGWGEEVDQVKNNNWESSANKPVSGWGEGGQSEIGTWGNGGNTNLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQQQPPPPQPEASGSWGGPPPPPQGNVRPSNSNWSSGPQPATPKDDEPSGWEEPSPQSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTGKSASDSKSMQDGWGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMKCSIKGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVDKKFDVDKRTMNLGDFNDIMRKDRPGFRPPNSKDLGTTDSGPYFEKGGSHGLFGNSTAQSRGLHTPVQPLSSSPGLRAQVPPQFISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQQQQQQQQQQQQQQRQPSMKHSPSHPVGPKPHLDNMVPNTLNVGLPDLPTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPASPWSSTAPRSVRGWGTQDSRIASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATEDEVSRFLAQAQPPTPAATPSAPATGWQSLETSQNQADPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGTSLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI
Protein: Vegetative-specific protein V4 (P14330)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Unknown. Its expression during growth is not required for growth but for the proper initiation of development, therefore playing a role in the transition from growth to development.
Interaction partners:
- SAC domain-containing protein
- Uncharacterized protein
- Carbohydrate-binding domain-containing protein
Sequence:
MSSINPSLYNDNGVYCSKVIVTKAIKIRDLDQIPQTVLALAATNNGANYDYASPNYITNARKRFKARLNRNPIWYPKMGDTAAIFFARSDQAGWDIRAEVDEAILYTQKQYPHIDINYAVLTPVNTHDLVDMNLIAQLFAEDDAAAAAAANQPNQPNQGQ
Protein: Nigrocin-2ISa (F1T156)
Organism: Odorrana ishikawae (Ishikawa's frog) (Rana ishikawae)
Function: Has antimicrobial activity against Gram-negative bacterium E.coli ATCC 8739 (MIC=25 ug), against Gram positive bacteria S.aureus ATCC 6538 (MIC=3.1 ug), methicillin-resistant S.aureus ATCC 43300 (MIC=12.5 ug), B.subtilis ATCC 6633 (MIC=12.5 ug) and against fungus C.albicans ATCC 90028 (MIC=50 ug).
Subcellular location: Secreted {ECO:0000305|PubMed:21193000}.
Interaction partners:
Sequence:
MFTLKKSMLLLFFLGTINLSLCQEERDAEEERRDEDNAKMEEIKRGIFSTVFKAGKGIVCGLTGLC