wanglab/gogpt-training-data huggingface dataset:
Protein: Nicotinic acetylcholine receptor Dalpha6 subunit variant type IV (Q8T7S0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLDEKNQLLITNLWLSLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKRSGSCLYVPPGIFKSTCKMDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ
Protein: Acetylserotonin O-methyltransferase 1 (OsASMT1) (EC 2.1.1.4) (Q6EPG8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24134674}.
Interaction partners:
- Serotonin N-acetyltransferase 1, chloroplastic
- Serotonin N-acetyltransferase 2, chloroplastic
Sequence:
MAQNVQENEQVMSTEDLLQAQIELYHHCLAFIKSMALRAATDLRIPDAIHCNGGAATLTDLAAHVGLHPTKLSHLRRLMRVLTLSGIFTVHDGDGEATYTLTRVSRLLLSDGVERTHGLSQMVRVFVNPVAVASQFSLHEWFTVEKAAAVSLFEVAHGCTRWEMIANDSKDGSMFNAGMVEDSSVAMDIILRKSSNVFRGINSLVDVGGGYGAVAAAVVRAFPDIKCTVLDLPHIVAKAPSNNNIQFVGGDLFEFIPAADVVLLKCILHCWQHDDCVKIMRRCKEAISARDAGGKVILIEVVVGIGSNETVPKEMQLLFDVFMMYTDGIEREEHEWKKIFLEAGFSDYKIIPVLGVRSIIEVYP
Protein: Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6) (P05182)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein. Microsome membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein. Mitochondrion inner membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein {ECO:0000305|PubMed:19401463}. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000305|PubMed:19401463}.
Interaction partners:
- UDP-glucuronosyltransferase 1A1
- Aldehyde dehydrogenase
- Cytochrome P450 1A2
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Cytochrome P450 7A1
- Cytochrome P450 3A
- UDP-glucuronosyltransferase
- Cytochrome P450 3A1
- UDP-glucuronosyltransferase 2B15
- UDP-glucuronosyltransferase
Sequence:
MAVLGITIALLVWVATLLVISIWKQIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVIPRS
Protein: Protein RER1 (Q5T094)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS
Protein: Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (Q9CPX6)
Organism: Mus musculus (Mouse)
Function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NT62}.
Interaction partners:
- Microtubule-associated protein 1 light chain 3 beta
- Autophagy-related protein 16-1
- Ubiquitin-like protein ATG12
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy protein 5
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Gamma-aminobutyric acid receptor-associated protein-like 1
- Microtubule-associated protein 1 light chain 3 alpha
- CASP8 and FADD-like apoptosis regulator
Sequence:
MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTDKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLESKDSIKLQDCSALCDEEDEEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKADAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM
Protein: PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (O75475)
Organism: Homo sapiens (Human)
Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Subcellular location: Nucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
Interaction partners:
- Menin
- Histone-lysine N-methyltransferase 2A
- Serine/arginine-rich splicing factor 1
- Pogo transposable element with ZNF domain
- Histone H3.2
- DNA endonuclease RBBP8
- Cell division cycle-associated 7-like protein
- Histone H4
- Retinoblastoma-binding protein 5
- Bromodomain-containing protein 4
Sequence:
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
Protein: Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) (Q8R0F3)
Organism: Mus musculus (Mouse)
Function: Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q8NBK3}.
Interaction partners:
- Inactive C-alpha-formylglycine-generating enzyme 2
- Arylsulfatase A
- N-acetylgalactosamine-6-sulfatase
- Arylsulfatase B
- Heparan N-sulfatase)
- Arylsulfatase G
- Iduronate 2-sulfatase
- Arylsulfatase I
- Arylsulfatase J
- N-acetylglucosamine-6-sulfatase
Sequence:
MAAPAREPALRCCIRLARVFLLLVLACEVAGSDEAEAREGAASLAGSCGCGTPQRAGAHGSSAAAQRYSREANAPGLTSGPRPLALTKMVPIPAGVFTMGTDDPQIRQDGEAPARRVTVDGFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEQVKTHIHQAVAAAPWWLPVKGANWRHPEGPDSSILHRSNHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGKFPVSNTGEDGFQGTAPVDAFPPNGYGLYNIVGNVWEWTSDWWTVHHSVEETFNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAD
Protein: Peptidase_M13_N domain-containing protein (O45569)
Organism: Caenorhabditis elegans
Interaction partners:
- C-type LECtin
- Carboxypeptidase
- MARVEL domain-containing protein
- C-type LECtin
- Carboxypeptidase
- G-protein coupled receptors family 1 profile domain-containing protein
- Nuclear Hormone Receptor family
- Protein irg-7
- Amine oxidase domain-containing protein
- Fungal lipase-like domain-containing protein
Sequence:
MAGPGSGNIVHTLLLVAGIVLTAGVLGVVIAILVNENNTNTNTNTIYNGTNTYNSTIQYNSTYVYNSTIIEIDIASKVLNVAQPAKVSPGTDKYNSYQQVVQLFKASVNLSVDPCNDFYAYTCGNFKGDMSFDISDNSNTNDMVTRLTNDTYISTAPLPVQQTRWYFDTCVNARQNWNTIADGSVVTAAINQLAAGNPGKHENSTKFPFPMLDQKTDVTTFPDRFGLGYLTGSLTAQGVDTIISAGVDTNWKDPAGPEGFAYLIDQPTTFAPNTYYLKDFDALNASLTYQITENMLQLAKVQNKTLDANILAKDVQDIIKLDYLLATKFSTDDTTRRQYDRSYNPNTLPQLLTQYHKDVFSWHMFLPIAVGTAEHVLDKLLDQGSGYNYYITMEPTKLNMLLTSLNKDNTLGITPRALVNYFYYRLVDSLSEFLPAPPAGNMIRPFVKIERQPVGRPRHVLPEDRKYERKLIEDLTEAQYSCAQETIDIQYANARLFIDQIYPTATDRKNVREHVAKVASSIVIGFRSMIDQLNWMTPSTKKGAYNKIENLVKNIAYPDWITDDAQLTAYHAPMNFTKTDTYVDMFFNVQNFNLYSQWDQLVQGPADRTGFNGPPGITNAWYQPELNSITFPAGILKKPFYDFNWPASVNFGAMGVIAGHELTHGFDDQGVQWNGVGTLSGWMDATSKVSFTNMAQCVVNEYSGFCPLDKATYGSAACIDGAQTQGENIADNGGIHSAFRAYKNYVDLYGPDPVLPDPQLQYFNPDQLFFLSFAQVWCQMPYTDAQFLRQILVDVHSPSIYRVLGTIQNFPAFKTAFNCPSSTYAPDNHCNVWVSDIDTTFGLPNVKTDINVVPEAPITSTNVDKMNAYQMAVDYYAKSVNTAIDPCDDFYSYACGNFNQSVSFYTARAQNLVYMAQKLEDPTYQTTINSSPALKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKLPSAKQIGDALGYLSFEQGIDTLISPLVDTYWIDNSKGYQMFIDQNTAYLSKTYYQPAAWKIEKPKYLKMALDVVTRYAREQNITLPAGASDLLSNVLDYEQNIAVKYSTDDNTRRQFQRSWNLTKTSDLVTKYNFMDWMTYLSHAPNAVKAKITDANYQVSVMEVDRLTHFSADYLQQSPELLVNLLFVRLLLGNAQYIPSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASVANNLMQFANGRVFVDYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNIAFPDWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFNIFVQYNQLNAAQTDRTDFLGQPGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHELTHGFDDQGVQWGPTGNLARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENIADNGGVHAAFNAYKTHQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHSPSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVWVPGKYQ
Protein: Xylan O-acetyltransferase 6 (EC 2.3.1.-) (Protein trichome birefringence-like 15) (OsTBL15) (Q10MX2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan. Catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q2QYU2}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MQQRRKSVFASAPFAMKQAALGAGVAARRNGAPLSLAAVVFALFVFATFLYNEDIKSIADFPFGAGALRAKSPDLHVLQETVGAAHLAAGSIAKRGEEVIVRVLDAPASTAMAAAAGSSSNNSTIEVAKANANANANAADAGVKVDEGQERERDVTLPSVKEGGADEARRREDEEAAEKESSAKAAAATAALRTVVSVPDTCDLYRGNWVYDEVNAPVYKESQCEFLTEQVTCMRNGRRDDSYQKWRWQPTDCDLPRFDARLLLERLRNKRLMFVGDSLNRNQWESMVCLVQSVIPKGKKTLTKFVNGGNSNIFYAHEYNATVEFYWAPFLVESNSDNPQVHSVPDRVIQWHSIAKHAHNWLGVDYLIFNTYIWWLNTLDMKVLKGSFDQGATEYVEVDRPVAYKEVLKTWAKWVDRNIDPNRTTVFFMSMSPNHITPEAWGNYGGIKCAMETLPITNRTTSLDVGTDWRLYAGAQEVLQTFRRVPVHLVDITALSELRKDAHTSVHTLRQGKLLTPEQQSDPKTYADCIHWCLPGLPDTWNQFLYARIASAPWSSDQ
Protein: Developmental pluripotency-associated protein 4 (Embryonic stem cell-associated transcript 15-1 protein) (ECAT15-1) (Q8CCG4)
Organism: Mus musculus (Mouse)
Function: May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage.
Subcellular location: Nucleus {ECO:0000269|PubMed:17855347, ECO:0000269|PubMed:21896782}. Note=Associated with transcriptionally active chromatin.
Interaction partners:
- POU domain, class 5, transcription factor 1
- Developmental pluripotency-associated protein 5A
- Zinc finger protein 42
- Undifferentiated embryonic cell transcription factor 1
- Homeobox protein NANOG
- Growth/differentiation factor 3
- Developmental pluripotency-associated protein 2
- Sal-like protein 4
- Developmental pluripotency-associated protein 3
Sequence:
METAGDKKWSAEEPKEEVELQMSSQPSTAPAKAKATGKKQKKSETDNGCKPKEGKPQDTETPGQTRRKVPIPPIPEYLPPVNLIHRDVLRAWCQKKRVSSKGQKLDAYKRLLARAFPEQMLELRNVPDSAKDARLKTAHKKMKTEPGEESEVTVPLEMVPVPEEQIPALIDPPMLYEEVSTTVVTTPATEAVLASWARIASNAKKYEAVPADASSSSEVKGEMWCVVHGTSLPGNSRGWVRLQFHAGQAWVPDKKGKAIALFLLPACTFPPPHLEDNMLCPKCVHKNKILTKSLEG
Protein: Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function) (Q9D5U8)
Organism: Mus musculus (Mouse)
Function: Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24339785}.
Interaction partners:
Sequence:
MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQIKLSWSQKIKSWTAKKKRKLYQLVIDIIMMNRVCKMFRQGLRGFREYQIIEPVHKKHPDFSFWDKKKQGRISFVTEDFAAQEGHFPPRAISITQKKPSWRTHQEIQDLCNILQALDCYRSYTESLQLLLAKVIRFERFGRRRVIVKKGQMGNSFYFIYLGTVAITEDEDGSSAFLDPHPTLLHRGGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALGRIERFSYGQMVSKDFMNSAFITFICQGNCEILRLVALGDCSAYYKWVWQQLELLDHKPLRIHDNEISPKERFKELQIKSYPLQDFTYLKLLRLQKAREQQGIDFHGKINKVENTLPKLLGPKIKSRFGHLVKCSMVNTKFGELPKEAIVGVYMKIHKTEEGEIVGLHQAFVPEIQRDCRPFILLSLGSELIQVRKEKFYDMVDEETRAKIIKMDVDYPSDEDLCQSFLKENDYIVFRKDLLRLLVEPLNKSPFIPVQTKKKEIYNHKSLFLDLCSLEKKVKQHYPIFLAPQKYLPPLRVVQAISAPRHKIQELLPQYKNAGVLI
Protein: Fre7p (A0A1D8PTG2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Fre30p
Sequence:
MTYHRHIARVMFMLIVIHAVCYTIRLKATYAQDMKETYLIWGVIATVCGGIILFQALLYFRRNWYETFLLIHIVMAALFVAGTWIHVVDFGYVWFVYPTVAVWCFDRLVRIIRLIYFGFPVAEVKLLTDDYSEEVVLRVTIPKPKYWKSIAGGHVFIHFLKPAYFWQSHPFTFVDSTVSDGHIVCYCKIKAGITRALYQMLMNTPDRCMPIRVGVEGPYGESTPARYADTCVFIAGGNGIPGIYSEIVDIANKQQSSKEEGCKRRLELIWVIRKCNMLSWFHNELANLKNTNIEVTIYVTQATQKDLGDHDNDKFTKSSESLSKSANDTDSSLSTISHAKFIHGRPCLEDIIKQEISESNGSVAFVSCGHPAMVDEIRYQISQNINNDERKRVDFYEQLQIWA
Protein: Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) (Q8C078)
Organism: Mus musculus (Mouse)
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching (By similarity). May be involved in hippocampal activation of CREB1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96RR4}. Cytoplasm {ECO:0000250|UniProtKB:Q96RR4}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96RR4}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000250|UniProtKB:Q96RR4}.
Interaction partners:
- Calmodulin-like protein 4
- Calmodulin-1
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 3
- 5'-AMP-activated protein kinase subunit gamma-1
- 5'-AMP-activated protein kinase subunit gamma-2
- 5'-AMP-activated protein kinase subunit gamma-3
- 5'-AMP-activated protein kinase subunit beta-2
- 5'-AMP-activated protein kinase subunit beta-1
Sequence:
MSSCVSSQPTSDRVAPQDELGSGGGSREGQKPCEALRGLSSLSIHLGMESFIVVTECEPGRGVDLNLARDQPPEADGQELPLEASDPESRSPLSGRKMSLQEPSQGGPASSSNSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTVESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGARPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTREWEPLSEPKEARQRRQPPGPRAGPCGGGGSALVKGGPCVESWGAPAPGSPPRMPPLQPEEVMEPE
Protein: Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (E7F8M2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- Sodium channel protein
- Transmembrane phosphatase with tensin homology
- Voltage-gated hydrogen channel 1
- Transient receptor potential cation channel subfamily V member 1
Sequence:
MTVATGDPSDEAAAHPGLPQDYDPGTEQECCERVVINISGLRFETQLKTLSQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVTLDVFSEEIRFYELGDEAIEIFREDEGFIKEEERPLPDNEFQKQVWLLFEYPESSGPARIIAIISVMVILISIVSFCLETLPIFRSDEEEMHKVPVNVNNSTTSYTSTYFTDPFFILETLCIIWFSFEFLVRFFACPSKASFFVNIMNMIDVVAIIPYFITLGTELAEKAEDGQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADEPESQFYSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVNVPKADSQEELKGSRSGSTISKSDYMEIQEGVNNSNEDFQEENLKTANCTLANTNYVNIKKMLTDV
Protein: Protein disulfide-isomerase (EC 5.3.4.1) (Q1HGL1)
Organism: Conus marmoreus (Marble cone)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}.
Interaction partners:
Sequence:
MKFSSCLVLTLLVFVSADDIKQEEGVYVLTKKNFDSFITENEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNIKLGKVDATVEEDLASKFEVRGYPTIKFFHKEKPNKPADYNGGRQAVDIVNWLKKKTGPPAKELKEKEEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKDGIVLLKKFDEGRNDFDGEFEEEAIVKHVRENQLPLVVEFTQESAQKIFGGEVKNHILLFLKKEGGEDTIEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLAEDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEGVDYNGERTLDAFVKFLESDGTEGAGVPEDEEEEEEDEEGDDEDLPRDEL
Protein: Protein GltF (P28721)
Organism: Escherichia coli (strain K12)
Function: Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized fimbrial chaperone YhcA
- Glutamate/aspartate import permease protein GltK
- Glutamate synthase small chain
- Glutamate synthase large chain
- Sodium/glutamate symporter
- Uncharacterized outer membrane usher protein YhcD
Sequence:
MFFKKNLTTAAICAALSVAAFSAMATDSTDTELTIIGEYTPGACTPVVTGGGIVDYGKHHNSALNPTGKSNKLVQLGRKNSTLNITCTAPTLIAVTSKDNRQSTIVALNDTSYIEKAYDTLVDMKGTKNAFGLGSAPNGQKIGAASIGIDRSNGGIHAADDTGEIPVDLIQTDHWSAATPTWKASSNGAFCSLTSCSAIERGYSVAKTGELTPVAITAVTFPLLIDAAVNDNTILGSDETIKLDGNVTISVQYL
Protein: ADP-glucose pyrophosphorylase family protein (F4IFA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mannose-1-phosphate guanylyltransferase 1
- Phosphomannomutase
- ADP-glucose pyrophosphorylase family protein
- GDP-mannose 4,6 dehydratase 1
- GDP-mannose 3,5-epimerase
- GDP-mannose 4,6 dehydratase 2
- Nudix hydrolase 14, chloroplastic
- Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase
- Mannose-6-phosphate isomerase 1
- Mannose-6-phosphate isomerase 2
Sequence:
MSEEKVVAVIMVGGPTKGTRFRPLSFNTPKPLIPLAGQPMIHHPISACKKISNLAQIFLIGFYEEREFALYVSSISNELKIPVRYLKEDKPHGSAGALYYFRDRIMEEKPSHVFLLNCDVCCSFPLQGILDAHRRYGGIGTMLVIKVSAEAASQFGELIADPDTKELLHYTEKPETFVSDLINCGVYVFTSDIFNAIEEVYSQIRDTSSNYQSATRSVPADFVRLDQDILSPLAGKKQLYTYENKDFWEQIKTPGKSLKCSALYLSQFRETSPHILASGDGTNRKPTIIGDVYIHPSVKLHPTAKIGPNVSISANVRVGPGVRLISCIILDDVEIKENAVVINSIIGWKSSIGRWSRVQASGDYNDRLGITILGEAVTVEDEVAVIGSIVLQNKTLNVSVQDDIIL
Protein: Neprilysin-2 (EC 3.4.24.-) (O44857)
Organism: Caenorhabditis elegans
Function: Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity.
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Presenilin spe-4
- Presenilin sel-12
- Presenilin hop-1
- Cathepsin B-like cysteine proteinase 5
- Peptidase C1A papain C-terminal domain-containing protein
- Cathepsin B-like cysteine proteinase 4
- Peptidase C1A papain C-terminal domain-containing protein
- Cathepsin B-like cysteine proteinase 6
- Peptidase C1A papain C-terminal domain-containing protein
- Insulin-degrading enzyme
Sequence:
MRPDEEDGTTKSPGSRWTRIWAIIALILLILFLLVLGAAIYFYINYKDSSDVCLSPGCIKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETSAVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW
Protein: Neuropeptide Y receptor type 2 (NPY-Y2 receptor) (Q6PR57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Peptide YY-A
- Pro-neuropeptide Y
Sequence:
MGQSDQVNGSEDTVLHDGNQETSLGNDSVNTYKPAFVDDITKHLSVQISLILAYSLIILLGLVGNTLVIYMIILYRNMRTVTNYFIANLALADLMVDTVCLPFTLVYTLLDEWKFGAVMCHMVPYSQALSVHVSILTLTIIALERYRCIVFHLGQRLNRCTSFIIIGLTWAFAAILAGPLAIFREYRYEEIPYIDLRIAVCSEKWPNGTNRDAVIYSLSMLLLQYVVPLAIISYAYVCIWIKLKNHVSPSNRNDGIVRRKKTTKMLALVVVVFAVCWLPFHMFQLASDLDLILKFKEYKLIYTLFHIVAMCSTFVNPLLYGWMNQNYRNGFLMFFRCEHKPDSIYPDGSFRTRSLRGMIVNGYNDGQPAAAV