wanglab/gogpt-training-data huggingface dataset:
Protein: Lysosomal associated membrane protein 3 (E7ETP9)
Organism: Homo sapiens (Human)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane {ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane protein {ECO:0000256|PROSITE-ProRule:PRU00740}.
Interaction partners:
Sequence:
MRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGNVDECSSDYTIVLPVIGAIVVGLCLMGMGVYKIRLRCQSSGYQRI
Protein: Polyprenyl synthetase (A0R029)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Interaction partners:
- 
- Phytoene synthase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
- Bifunctional short chain isoprenyl diphosphate synthase
- Isopentenyl-diphosphate delta-isomerase
- Alpha-
- Decaprenyl diphosphate synthase
- Phytoene dehydrogenase
- 1-deoxy-D-xylulose-5-phosphate synthase
Sequence:
MDTAAPSAVELAGAVTEQLREYLRERRSDCAYIGPVYAELTAGVEEFVLRGGKRVRPAFAYWGWRSVIEPADAVAGPDVLRLFSALELLQACALIHDDVIDDSATRRGLPTVHRLFTEQHHERGWLGSERQFGLSAAILAGDLALSWADDIVAGADLPVDAHRRVQTVWRHIRTEVLGGQYLDIVTESSGDESVASALNVNTFKTASYTVARPLQLGAAAAADRPDVQELFHRIGNDLGVAFQLRDDVLGVFGDPAVTGKPSGDDLRSGKRTVLLAEALELADASDPAAAALLRRSVGTELSDTQVRELCDAIESVGALAAVEQRIETLTRDALDVLAAANVHPQAKAGLSELARSAANRTA
Protein: ER membrane protein complex subunit 3 (Q9VKR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 7
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 8/9 homolog
- Membrane magnesium transporter
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 2
- Dynactin subunit 4
Sequence:
MTELLIDPDIRVWVFLPIVLITFLVGIVRHYVSILISTQKKAEITQIQDSQAMIRARLLRENGKYLSAQSFSMRKNYFNNEETGYFKTQKRAPVAQNSSAMLTDMVKGNFINVLPMVVIGGWINWMFSGFVTTKVPFPLTLRFKPMLQRGVELASLDAAWVSSASWYFLNVFGLRSIYTLVLGENNHADQTQAQADAMTGAAMTMPQDPKAAFKAEWEALEITEYHNALKNIDADMLAIASAPAASS
Protein: Phosphoglucosamine mutase (EC 5.4.2.10) (Q6LYB4)
Organism: Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Also catalyzes the isomerization of glucose-1-phosphate to glucose-6-phosphate, but at a 5-fold lower rate.
Interaction partners:
- Bifunctional protein GlmU
- Glutamine--fructose-6-phosphate aminotransferase
- Diadenylate cyclase
- dUTP diphosphatase
Sequence:
MKLFGTSGIRMKNLDPLIAYKVGFAISKNFKKAVIGRDTRTTGNLIESAITAGLLNGGCDVTTIGMVPTPVLGYSAKDYDLGIMITASHNPPEYNGIKLFNKNGTAFDPKQEKELENIINNDDFNECTWDNIGCVVEDKTAVKKYFEYILQNLNLNTNFNVVVDCANAAGCVVSPNIFTEAGCKVISVNSHCDGRFVGRMPEPNETNLKETVDIIKGLNSNGRNYVGIAHDGDADRMIAIDELGRVTDFDKLLAAFCKYLVQKTGADKIVTTVDASMAIEEYLNEFGAKVIRTKIGDVAVAEELEKTGAIFGGEPSGTWIHRDIHLTPDGILSGLRVLEMMEFYGKKLHEIIDEVPSYCNMREKISCPDNLKQNVMDYVSKEGEKIFEKKPETLDGVRFSFENGWILIRPSGTESYVRVRVEAKEKDFAEKLMKTGISMVKTGISGK
Protein: Acyl-CoA binding domain containing 4 (Acyl-Coenzyme A binding domain containing 4, isoform CRA_b) (K7EM05)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVFCDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEAAAQAQCSAMAPWAPGARAALLPPVALRRPVALPNVSDPKEVTVSGGVSAAN
Protein: Uncharacterized protein (Q57UV8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGSCCGANAMPVVDNSENSKPQRKRNVTFSTFPALDIEVHRPGGDADSMLSLTRRSSTFPMDQTMYTVSEFNATLADTVRSLNLTPRDDVGRSLVTNGLDEVSERDVDSFVDDVLHIGLLDSLVTVEERVGNGYGLGSRCLSPSGGLGGPVWLSKEQLQYLERAPDTSERLARLAELEEMSRQEIFAAWLMNSTLLKMGAARVIPTIRRCRAANEKASKNRDVIVIHAKDINVRANDDPGLERNWNSPRFEALGHTGSFSPPDESGVDEPSPEVTEHYQILALTGRAVNVKNKVRSHIVSDTWDFLSRCEASEVLNKGDVFFRFVCSPITNLSEDSLKIIDTLINLSSFRDELGENNVPRVDVYSNEEQRKYVSILVKTMNLLPGVSISSITPELVASLDYQRSCQPGENKFEPSDDPHTFRQVKTLIRFIYSITIQMKVSEITDSNVLLNLKEIDGMVPAKALMLERTKKNIMSSDSTVKVRSFLLYYPVNEGVLVNNQTIVINKSLPRVASKLLQTFGSQGASDAVKTAVQTRNYFFNRFGDGRTGGI
Protein: CTCF (GH14774p) (Q9VS55)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Centrosome-associated zinc finger protein Cp190
- FI11703p
- Boundary element associated factor
- Structural maintenance of chromosomes protein
- Modifier of mdg4
- DNA-directed RNA polymerase II subunit RPB3
- TBP-associated factor 3
- Enhancer of yellow 2 transcription factor
- Histone H3.3A
- Histone H3
Sequence:
MPRRTKKDEDPEDLQTFLNNFHKEIEGNSDEKVVNTILEAISAEAIDLDENGAEAGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQARLAASEKQPMIINQRLRSQRGTKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGDEEVLVKHEPSANSKISAKNCFGFEDDDDYEEYGDGENEVDGASQEFLQLMDMIEQDS
Protein: ATP-dependent DNA helicase Q-like 2 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ2) (RecQ-like protein 2) (AtRQ2) (AtRecQ2) (AtRecQl2) (Q9FT73)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 3'-5' DNA helicase that may play a role in the repair of DNA. Its DNA unwinding activity in vitro is dependent on magnesium, and ATP or dATP. Can use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors. Catalyzes Holliday junction branch migration and replication fork regression. Disrupts D-loop structures.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 22a
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 22b
- Mediator of RNA polymerase II transcription subunit 9
- Mediator of RNA polymerase II transcription subunit 32
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MESEAIQEDLQNLDVELKDVQGQISALIEHQDRLYERKSELKTLLKALAASGSPVASSGGSSAIENWSETFEWDSRADDVRFNVFGISKYRANQKEIINAIMTGRDVLVIMAAGGGKSLCYQLPAMLRGGTTLVVSPLLSLIQDQVMGLAALGISAYMLTSTSGKENEKFVYKALEKGEDDLKILYVTPEKVSKSKRFMSKLEKCHNAGRLSLISIDEAHCCSQWGHDFRPDYKNLSILKTQFPKVPMVALTATATQKVQNDLIEMLHIPKCVKFVSSVNRPNLFYSVREKSAVGKLVVDEIAEFIRESYSNNESGIVYCFSRKECEQIAGDLRERGISADYYHADMDANMREKVHMRWSKNKLQVIVGTVAFGMGINKPDVRFVIHHSLSKSMETYYQESGRAGRDGLPSECILFFRSADVPRQSSMVFYEYSGLQNLYDIVRYCQSKTKCRRSAFFRHFGEPSQDCNGMCDNCALSSEVKEVDVSDLSKLVVSMVQETQAKDQRVTMLQLGDKLRNKHKDLIAELKRDEVEHLVIKLIVDSVLKEEFQHTPYSTNAYVTMGPLANQLLQGRKTIKMETSSRQTKKLKRSITFSGLELKLDELRKEISAADGSILPHTVLSTQQIGSISSQKPVSLQELESIIGKLKTEKYGDRILEEVMRHEAVSEQLVEDPTKEETCKSRLRKRAKTQKDVVLVESSGEEEA
Protein: Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) (Q8R3G1)
Organism: Mus musculus (Mouse)
Function: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development.
Subcellular location: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Mainly, but not exclusively, nuclear.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Splicing factor 3B subunit 1
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase 1 regulatory subunit 10
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Sequence:
MAAAVNSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRMEGSGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSETGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVAINPTPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
Protein: Fe2OG dioxygenase domain-containing protein (B1V8J3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MYPIYIFFIYSTYIFNFLTPFTDETLEFNDKIWDKCGKELRGDSSRDGRLVCYRLHKHLLIRKVEILSSEPFILQYHNQVHRRLAKRAVQEAEALRLEQLKISGFTTTPEKSQVRAANGTWLIHTGRPSFARIFEGLQANINSLDLSTAEPWQILSYNADGYYAPHYDYLNPATNVQLVEGRGNRIATVLVILQIAKKGGTTVFPRLNLNIRPKAGDVIVWLNTLSTGESNSQTLHAACPIHEGTKIGATLWVHEKKQEFSLPCALTNKLYNTKHFFS
Protein: Heterogeneous nuclear ribonucleoprotein R (hnRNP R) (O43390)
Organism: Homo sapiens (Human)
Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
Subcellular location: Nucleus {ECO:0000269|PubMed:31079900}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250|UniProtKB:Q7TMK9, ECO:0000269|PubMed:17289661}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Heterogeneous nuclear ribonucleoprotein M
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoprotein L
- Heterogeneous nuclear ribonucleoprotein Q
- Heterogeneous nuclear ribonucleoprotein U
- Heterogeneous nuclear ribonucleoprotein H
- RNA-binding motif protein, X chromosome
- Serine/arginine-rich splicing factor 1
Sequence:
MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK
Protein: C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (CC chemokine ST38) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) (P97884)
Organism: Rattus norvegicus (Rat)
Function: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P78556}.
Interaction partners:
- C-C motif chemokine receptor 6
- C-C motif chemokine receptor 7
- C-C chemokine receptor type 5
- C-X-C chemokine receptor type 3
- Macrophage inflammatory protein-1 alpha receptor
- C-C motif chemokine 2
- Growth-regulated alpha protein
- C-C motif chemokine receptor 8
- C-C chemokine receptor type 10
- C-X-C chemokine receptor type 6
Sequence:
MACKHLPFLALAGVLLAYLCSQSEAASNFDCCLTYTKNVYHHARNFVGFTTQMADEACDINAIIFHLKSKRSVCADPKQIWVKRILHLLSLRTKKM
Protein: Codeine O-demethylase (EC 1.14.11.32) (Thebaine 6-O-demethylase) (EC 1.14.11.31) (D4N502)
Organism: Papaver somniferum (Opium poppy)
Function: Non-heme dioxygenase catalyzing the conversion of codeine to morphine. Catalyzes also, with lower efficiency, the 3-O-demethylation of thebaine to oripavine and of (S)-scoulerine to 3-O-demethylscoulerine. No activity with (S)-reticuline, salutaridine, papaverine, (S)-corytuberine, oripavine, pavine or noscapine.
Interaction partners:
Sequence:
METPILIKLGNGLSIPSVQELAKLTLAEIPSRYTCTGESPLNNIGASVTDDETVPVIDLQNLLSPEPVVGKLELDKLHSACKEWGFFQLVNHGVDALLMDNIKSEIKGFFNLPMNEKTKYGQQDGDFEGFGQPYIESEDQRLDWTEVFSMLSLPLHLRKPHLFPELPLPFRETLESYLSKMKKLSTVVFEMLEKSLQLVEIKGMTDLFEDGLQTMRMNYYPPCPRPELVLGLTSHSDFSGLTILLQLNEVEGLQIRKEERWISIKPLPDAFIVNVGDILEIMTNGIYRSVEHRAVVNSTKERLSIATFHDSKLESEIGPISSLVTPETPALFKRGRYEDILKENLSRKLDGKSFLDYMRM
Protein: Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas) (D6RGH6)
Organism: Homo sapiens (Human)
Function: Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1.
Subcellular location: Nucleus {ECO:0000269|PubMed:21543332, ECO:0000269|PubMed:25048963}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:21543332}.
Interaction partners:
- Geminin
- Transcription factor E2F4
- Cyclin-O
- Geminin coiled-coil domain-containing protein 1
- Transcription factor E2F5
- Forkhead box protein J1
Sequence:
MQACGGGAAGRRAFDSICPNRMLALPGRALLCKPGKPERKFAPPRKFFPGCTGGSPVSVYEDPPDAEPTALPALTTIDLQDLADCSSLLGSDAPPGGDLAASQNHSHQTEADFNLQDFRDTVDDLISDSSSMMSPTLASGDFPFSPCDISPFGPCLSPPLDPRALQSPPLRPPDVPPPEQYWKEVADQNQRALGDALVENNQLHVTLTQKQEEIASLKERNVQLKELASRTRHLASVLDKLMITQSRDCGAAAEPFLLKAKAKRSLEELVSAAGQDCAEVDAILREISERCDEALQSRDPKRPRLLPEPANTDTRPGNLHGAFRGLRTDCSRSALNLSHSELEEGGSFSTRIRSHSTIRTLAFPQGNAFTIRTANGGYKFRWVPS
Protein: Calcineurin B-like protein 5 (SOS3-like calcium-binding protein 4) (Q7FZF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a positive regulator of salt or drought responses.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19832944}. Nucleus {ECO:0000269|PubMed:19832944}. Note=Targeted to the cell membrane when interacting with CIPK24.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 11
- CBL-interacting serine/threonine-protein kinase 24
- Calcium-dependent protein kinase 21
- Peptidyl-prolyl cis-trans isomerase FKBP12
- CBL-interacting serine/threonine-protein kinase 23
- CBL-interacting serine/threonine-protein kinase 6
- Guard cell S-type anion channel SLAC1
- Potassium channel AKT2/3
- Calcium-dependent protein kinase 23
- CBL-interacting serine/threonine-protein kinase 14
Sequence:
MGCVCSKQLEGRRQEDISLLASQTFFSEAEVEVLHGLFIKLTSCLSNDNLLTKEKFQFILIKNTKKRSLSAERIFGLFDMRNDGAIDFGEFVHTLNIFHPNSSPRDKAIFAFRLYDTRETGFIEPEEVKEMIIDVLEESELMLSESIIDSIVSKTFEEADWKKDGIIDLEEWENFVATYPLTLKNMTIPFLKDIPRIFPTFLR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0B8RZS0)
Organism: Sus scrofa domesticus (domestic pig)
Interaction partners:
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGAGEDPMDYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLTVNWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIRE
Protein: Histone-lysine N-methyltransferase KMT5C (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) (Q6Q783)
Organism: Mus musculus (Mouse)
Function: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
Subcellular location: Nucleus {ECO:0000269|PubMed:15145825}. Chromosome {ECO:0000269|PubMed:15145825}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
Interaction partners:
- Histone H4
- N-lysine methyltransferase KMT5A
- Histone-lysine N-methyltransferase SUV39H2
- Histone-lysine N-methyltransferase SUV39H1
- Histone-lysine N-methyltransferase EHMT2
- Chromobox protein homolog 5
Sequence:
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRRQHHLRSALEAFLRQRDLEAAFRALTLGGWMAHYFQSRAPRQEAALKTHIFCYLRAFLPESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREEDEDLLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNTACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECYTCERKGEGAFRLQPREPELRPKPLDKYELRETKRRLQQGLVSSQQSLMSRWACSHLSPLRPDPFCAACQPSCLLPASPHMDYLPLWLQRAPQPQPIVPPRKRHRRRRPRIRQASLPPVLRTACVPLHRWGGCGPHCQLRAEAMVTLHLRPQTRWTPQQDWYWARRYGLPSVGRVELTRLAPALPAAPAPAGNPGPVPTPDFIPKQALAFAPFCPPKRLRLVVSHGSIDLDINSGEP
Protein: 40S ribosomal protein L14, putative (Q583T1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L27, putative
- 60S ribosomal protein L19, putative
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L6, putative
- 60S ribosomal protein L13a, putative
- 60S ribosomal protein L27a
- 60S ribosomal protein L39, putative
- 60S ribosomal protein L35A, putative
Sequence:
MVKANYIRAGRLVRILRGPRQNRVGVIVDIVDANRVLVENPCEQKMWRHVQNLKNVEPLKFCVSISRNCSTKALKEALESKKVLEKYAATKSAVRIAAKKAFAESTDFERYQLRVAKRSRAYWARKIFDENDKKNPVSWHKVALKKLLKNAKKVDSTPAAKKRVEKARAARKARVASGKTKAKSTAGKN
Protein: NADP-dependent 3-hydroxy acid dehydrogenase (L-allo-threonine dehydrogenase) (EC 1.1.1.-, EC 1.1.1.381) (Q05016)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Low specificity L-threonine aldolase
- L-2-aminoadipate reductase
- Alcohol dehydrogenase 4
- Aldehyde reductase YPR1
Sequence:
MSQGRKAAERLAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTALINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINTKIRVILIAPGLVETEFSLVRYRGNEEQAKNVYKDTTPLMADDVADLIVYATSRKQNTVIADTLIFPTNQASPHHIFRG
Protein: Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) (Q63117)
Organism: Rattus norvegicus (Rat)
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
Interaction partners:
- Ubiquitin-like protein 7
Sequence:
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
Protein: Thaumatin-like protein (allergen Act d 2) (P81370)
Organism: Actinidia deliciosa (Kiwi)
Function: Has antifungal activity.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MSTFKSLSLSALLFIAFLFTCARGATFNIINNCPFTVWAAAVPGGGKRLDRGQNWIINPGAGTKGARVWPRTGCNFDGAGRGKCQTGDCNGLLQCQAFGQPPNTLAEYALNQFNNLDFFDISLVDGFNVAMEFSPTSGGCTRGIKCTADINGQCPNELRAPGGCNNPCTVFKTDQYCCNSGNCGLTNFSKFFKDRCPDAYSYPKDDQTSTFTCPAGTNYKVVFCP