wanglab/gogpt-training-data huggingface dataset:
Protein: Protein FEV (Protein Pet-1) (A3FEM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Functions as a transcriptional regulator. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Tryptophan hydroxylase 1b.
- Tryptophan hydroxylase 2
- Transporter
Sequence:
MKAYPFTSTTATTMRQNCGGSLMFNMYLSDPTENLLKESKSPSWTPINTGVQKGSGQIQLWQFLLELLSDSANMTCIAWEGTNGEFKLIDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFNGLAQVCQPSSTEQAIYKFQSNFAPIQFSGISKLNLVAPGVGPSGFSYWPGSPPTLYHSHNLQPPGPFGAVSASHLSCVNNINSLNNLNNINNHYN
Protein: GH01508p (Jonah 65Aiii (EC 3.4.21.-)) (Q9VRS7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- trypsin
- Jonah 65Aiv
- Trypsin beta
- Trypsin alpha
- Uncharacterized protein
- Zinc carboxypeptidase A 1
- GH20109p
- Trypsin epsilon
- RE65433p
- Jonah 25Bii, isoform A
Sequence:
MKVLVVFALALATASAGLLPQQVPIHPRDLPAVTNIEGRITNGKTATSGQFPYQVGLSFASTSGSWWCGGSIIDNTWVLTAAHCTSGASAVTIYYGATVRTSAQLVQTVSADNFVQHASYNSIVLRNDISLIKTPTVAFTALINKVELPAIAGTYSTYTGQQAIASGWGKTSDSATSVANTLQYEVFEVVSVSQCQNTYGSLVATNNVICVATPNKVSTCNGDSGGPLVLVSDSKLIGVTSFVSSAGCESGAPAGFTRVTSYLDWIKTNTGVSY
Protein: Probable glutathione peroxidase 3, mitochondrial (EC 1.11.1.9) (O22850)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May constitute a glutathione peroxidase-like protective system against oxidative stresses. Involved positively in abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Oxidizes and represses target proteins (e.g. the phosphatase activity of ABI1 and ABI2) when oxidized by H(2)O(2), probably after ABA signaling. Modulates the calcium channel activity in guard cells in response to ABA or H(2)O(2). Confers tolerance to drought stress, by enhancing the ABA-dependent stomatal closure.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Glutathione reductase, chloroplastic
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase DHAR2
- Glutathione synthetase, chloroplastic
- L-ascorbate peroxidase 3
- Monodehydroascorbate reductase 3
- Glutathione S-transferase T1
- Glutathione S-transferase F6
- Glutathione S-transferase U19
- Glutathione S-transferase F9
Sequence:
MPRSSRWVNQRATSKIKKFILFLGVAFVFYLYRYPSSPSTVEQSSTSIYNISVKDIEGKDVSLSKFTGKVLLIVNVASKCGLTHGNYKEMNILYAKYKTQGFEILAFPCNQFGSQEPGSNMEIKETVCNIFKAEFPIFDKIEVNGKNTCPLYNFLKEQKGGLFGDAIKWNFAKFLVDRQGNVVDRYAPTTSPLEIEKDIVKLLASA
Protein: Stretch-activated cation channel MID1 (Mating pheromone-induced death protein 2) (P41821)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Calcium-permeable, cation-selective stretch-activated channel (SAC). Required for calcium influx and for vitality of MATa cells in a late, pheromone-induced event of the mating process requiring calcium induced signaling. Functions together with CCH1 to ensure that adequate levels of Ca(2+) are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments. Together with CCH1, essential for tolerance to iron stress, which leads to an increased oxidative poise, and to cold stress.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14729456, ECO:0000269|PubMed:16202999, ECO:0000269|PubMed:7526155}; Single-pass type I membrane protein {ECO:0000255}. Note=Trafficking to the plasma membrane is dependent on the N-glycosylation and the transporter protein SEC12. {ECO:0000269|PubMed:16202999}.
Interaction partners:
- Calcium-channel protein CCH1
- Protein ECM7
- Vacuolar calcium ion transporter
- Calcium-transporting ATPase 2
- Calcium-transporting ATPase 1
- Calcium channel YVC1
- Transcriptional regulator CRZ1
- MAP kinase kinase PBS2
- Calcineurin subunit B
- CRE-binding bZIP protein SKO1
Sequence:
MIVWQALFVVYCLFTTSIHGLFQDFNPFANKNISLKFPSLNRWEKNVMATGQQTIINSDSIYEWTPILSNITAGKKDSFVFTIDAEASGYGFAPTYEVLMFISGNICQMPMNRSDVDLTIYYSFNETVLENPNIGQSAVFQDGYIQALAISPVQSSSSNATSTYSNLYVVAELVNSTTEQPLSSSDASENWEYRLSISENDLVFQWDVRPWVEVLDTDMNSALLSTGNVTADAKVYHNYSIYDPSLYDLYVYSYEDSVQLNQNYNLSLCAVKNGPYLVSSQNTSNATVTSNSTNPLERTDLAIQKKITEYGGSVTEMFYVTGLNASTTYVAYLTKKISNGDGLSSVGGILFSHVYFTTRSTDVCSLIFGLDFCSDVAYSVPTSSFSVGNKTLMAQTYDHIAEALYANFSKALQLISCDADKDARYSPVMTCDDCAEAYRDWVCAVSIPRCTTTSSQYYIHRDKSHNRNDYLNKFIKPLDDYYEILPCIDMCYTLVRNCPSDFQFSCPNDLTTEDLLYQSYNFYMDTDYSTCNYIGNSSLMVIHPLDDT
Protein: Transcription initiation factor TFIID subunit 9 (TBP-associated transcription factor family member taf-9) (O45784)
Organism: Caenorhabditis elegans
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-9 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:11566890}.
Interaction partners:
- Transcription initiation factor TFIID subunit 2
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 4
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 1
- Transcription-associated protein 1
Sequence:
MADTGEKDTETTASGTDGHSKEALAVISMLHECGIQEFDPRVVSMLMDVQYAVTSKILQMSSGLSRHAEKAQIEAEDVQTAADMLGVLTTNAPDREKILQLANDKNQQPLPQIRHNYGLKLPNDRFCQLQQNFVYKADDSYQPMEMQQVTHQPHIIEPPTQVLRPEHVQNMLKRRAPDDDFDS
Protein: At2g29590 (Expressed protein) (Thioesterase superfamily protein) (Q9ZW37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 2-carboxy-1,4-naphthoquinone phytyltransferase, chloroplastic
Sequence:
MMEKIMEYLQLSDEVVDDGEAPRVEEFLGEGKSFYENFSLRGIRVNRVEPGFISCSFKVPLRLTDRDKNLANGAIANLVDEVGGALVHGEGLPMSVSVDMSIAFLSKAKLGEELEITSRLLGERGGYKGTIVVVRNKMTGEIIAEGRHSMFGRQASKL
Protein: Transcription factor DICHOTOMA (Q9SNW8)
Organism: Antirrhinum majus (Garden snapdragon)
Function: Transcription regulator involved in the dorsovental asymmetry of flowers. Promotes dorsal identity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00701}.
Interaction partners:
Sequence:
MFNKKRYLQYPQVPPSLNPRASTSVVSLNGNEILLHHHDVISGYYLASNPQNLEPDALFNGFHHDVGGTNGDPLVLANTLAKKHTPKKDRHSKINRPQGPRDRRVRLSIGIARKFFDLQEMLGFDKPSKTLDWLLTKSKEAIKELVQSKSSKSNISNSPSECDQEVLSADLPYIGSSKGKAAVGLNSNKCKGGRDAVDLAKESRAKARARARERTKEKMCIKQLNQERNKSYEWNPSVLFQSKSSQQFEVSGPSTNYEELNQESIMIKRKLKQNHPSMFGFQPENATENWDYYSNFTSQSNQLCAILDQHKFIN
Protein: 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (E9AFC6)
Organism: Leishmania major
Interaction partners:
Sequence:
MHPIFDYILSIHYLPAGASVLLSCLAAAWGVDWKVCIMMTCVGSLVTCAVFYVQPLQCFSPLGGSFNVGTREVCGERGAMKPPVTIVYPTASGTPRSGIQYIPFGERSYLVGIASYSKVPYALVKDLWLLRKKMRPNAEPAPLFQRDGMPRPMIVFSHGLGGFPHLYSTLLMDLAVRGAVVFALSHMDGSAAFCRDAEREIRIPLNTQVGWTSEDRAPQLEVRIRETLNTIKRIRSGELLLALGYDKETVDKYIEKEPRIHLLGHSFGGATCLAAALADTQAASERGGVSSIASTVVYDPWMIPLQKTMFYDKLTDRKQPVHFTTPTLQIFSEEWVRSKEQHAFFEEVKAIVDAQPRTTEESALVSAVDAKLKVMKTSWYTIKDYRGTGHLTCTDVSLFSPVLYRAAYMTASPRGCIVAFAAETMRFIEKVSGPLPLDTKLLNDSALAAALRG
Protein: TBC1 domain family member 24 (A0A0G2K5B0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Ras-related protein Rab-35
- ADP-ribosylation factor 6
Sequence:
MDSPGYNCFVDKDKMDASIQDLGPKELNYTELQELKQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVPTYCLNPRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPGKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKSVSLSKRQFVHLAVHAENFRSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERNKFGGKLSFFGTGECFVFRLQPEVQRYEWVVIKHPELTKAASFKSSEAAANPCLISHSVSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGGGGQALYIDGDLNRGRTGHCDTFNNQPLCSESFLIAAVEAWGFQDPDTQ
Protein: Alpha-D-galactose-binding lectin (Galactose-binding lectin) (Lectin) (MytiLec) (MytiLec-1) (R-type lectin) (B3EWR1)
Organism: Mytilus galloprovincialis (Mediterranean mussel)
Function: Alpha-D-galactose-binding lectin. Binds D-GalNAc, but not glucose or its derivatives. Has hemagglutinating activity towards rabbit erythrocytes. Agglutinates bacteria. Has bacteriostatic activity on both Gram-positive and Gram-negative bacteria including B.subtilis, S.aureus, E.coli and V.parahaemolyticus, respectively. Has a dose-dependent cytotoxic effect on the human globotriaosylceramide (Gb3)-expressing Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (Raji) cell line. Has dose-dependent cytotoxic effect on another Burkitt's lymphoma (Ramos) cell line, which does not possess the EBV genome, but also expresses Gb3. Binds to Gb3 in these cells leading to phosphorylation of MEK1/2, ERK1/2, JNK and p38 kinase, activation of caspase-9/3 and to expression of p21 and tumor necrosis factor (TNF)-alpha. No cytotoxic effect on the human chronic myelogenous leukemia (K-562) cell line, which does not express Gb3. May be involved in innate immunity acting as an antibacterial or antifungal agent. May be a pattern recognition receptor (PRR) involved in recognition of glycans found on parasitic or symbiotic microorganisms.
Interaction partners:
Sequence:
MTFAKQSCFNSIILLSIATSYFKIGHKISELGNRIEKMTTFLIKHKASGKFLHPKGGSSNPANDTNLVLHSDIHERMYFQFDVVDERWGYIKHAASGKIVHPLGGKADPPNETKLVLHQDRHDRALFAMDFFNDNIIHKAGKYVHPKGGSTNPPNETLTVMHGDKHGAMEFIFVSPKNKDKRVLVYV
Protein: proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) (P96833)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- NAD
- NAD
- Probable soluble pyridine nucleotide transhydrogenase
- NAD kinase
- Glutamine-dependent NAD
- NAD-dependent protein deacylase
- Probable nicotinate-nucleotide adenylyltransferase
- NAD-capped RNA hydrolase NudC
- Possible transcriptional regulatory protein NadR
Sequence:
MYNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGIVVLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAKPDRDEALR
Protein: Neuregulin 2a (Zgc:162973 protein) (A5D6U9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Erb-b2 receptor tyrosine kinase 3a.
- Receptor protein-tyrosine kinase.
- Erb-b2 receptor tyrosine kinase 3b.
- Receptor protein-tyrosine kinase.
- Receptor protein-tyrosine kinase.
- Neuregulin 2
- Receptor protein-tyrosine kinase.
- Ribonuclease/angiogenin inhibitor 1
Sequence:
MKNPVLADEGSRLIVKCEATGSPAPEYKWYKDGAELKRSKEIKIRNNKKNSKVQIGSAKLEDSGNYTCVAENILGKANGTSTVHVQSITTTVSPGSGHARRCNDTEKTYCVNGGDCYYIHGINQLSCKCPDGYFGPRCLQTEPLRLYMPKPNKKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKKMHNHLRQNIYVDHPNRNLANGPNHPGPGPEEIPMVDYISKNVPATERVIRHGAEAPFPGSRQSSRSHNSSTRAHSSTHRYVSALTTPARLSPVDFHYSLPPQVPTFQITSPNASHAMSLPPAAHAPYPPEEDQPLLRRYQVPLHEARGHEPYRQQQRGSYLRDSTGSLPSSPYRLAQEDEYESTQEYLSSMEQPKRSSRRWRRSRLNGHVAPRGYQPSRDLGSRSCLSDSDSEEEEGESTPFLSMQNMNAAEPSALYRPVPDTRTSHAQSGRHGSRANTQTRLTHSRSKPDNAPH
Protein: Solute carrier family 15 member 3 (F5H251)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEMERLHYIHHNETVSQQIGEVLYNAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQGPASHSRFSRDRG
Protein: TATA-binding protein 2 (TATA sequence-binding protein 2) (TBP-2) (TATA-binding factor 2) (TATA-box factor 2) (Transcription initiation factor TFIID TBP-2 subunit) (Q8W0W4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (Probable). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor IIA subunit 2
- Os01g0510800 protein
- Transcription initiation factor TFIID subunit 13
- Os05g0292200 protein
- Os01g0680400 protein
- Os03g0840500 protein
- Os09g0431500 protein
- Transcription initiation factor IIF subunit alpha
- Os09g0110400 protein
- Transcription initiation factor IIB
Sequence:
MAAEAAAALEGSEPVDLAKHPSGIIPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEQQSKLAARKYARIIQKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYSHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVLTGAKVRDETYTAFENIYPVLTEFRKVQQ
Protein: Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Gastrointestinal glutathione peroxidase) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Glutathione peroxidase-related protein 2) (GPRP-2) (Phospholipid hydroperoxide glutathione peroxidase GPX2) (EC 1.11.1.12) (P18283)
Organism: Homo sapiens (Human)
Function: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:8428933}.
Interaction partners:
- Glutathione reductase, mitochondrial
- Peroxiredoxin-6
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Glutathione synthetase
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Polyunsaturated fatty acid 5-lipoxygenase
- Thioredoxin
- Glutathione peroxidase 7
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Probable glutathione peroxidase 8
Sequence:
MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI
Protein: Preferentially expressed antigen in melanoma-like protein 1 (Prame-like 1) (Q99MW3)
Organism: Mus musculus (Mouse)
Function: May play a role in acrosome development and also in sperm maturation and motility.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23565261}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:23565261}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:23565261}. Note=Located in the cytoplasm of spermatocytes and in the acrosomal vesicle region of round, elongating and elongated spermatids. Detected in the main piece of the flagellum in testicular spermatozoa. Detected also in the connecting piece, middle piece and cytoplasmic droplets of epididymal spermatozoa. {ECO:0000269|PubMed:23565261}.
Interaction partners:
- Preferentially expressed antigen in melanoma-like protein 7
- Cullin-2
- PRAME like 6
- PRAME like 47
- PRAME like 13
- Oog4 protein
- Oogenesin-1
- 4732496O08Rik protein
- PRAME like 31
- PRAME like 19
Sequence:
MSCKTPPTLQELAENSLLKNQDLAISALDDIPSLFFPSLFKKACRNRYVGIIKAMVQAWPFPCLPLGAMISRKTAYRRILEIILYGLDALLSQKVPHSRCKLQVLDLRVMPLKLWNRLPVFGTAGCSENPAVVGHSGTEVKQPVKVLVDLVLKESPLDSTESFLVQWVDNRNGLVSLCCCKLQIWAMSMYYHRKLLEILDLDSVQELRMYCISNPVCLLNFAPYLGRMRNLRCLILSHLWQTFSMTPVEKQQVITQFTSQFLKLKCLQILHLDTVFFLEGHLDELFWWLKTPLETLSVIDCNLSKSDWFHISEFQCTSQLKHLNLKWVKLTHLSPEPLRVLLLKSASTLTSLDLEGCQMMDSQLSAILPALRCCTQLTKFNFHGNYISMPILRELAYNVVKQKSQQSKIRFIPSCSHHSGLEFEAISQPHIVFVDVDRTTGEQEQVLFYAICSGEYVL
Protein: Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) (Q5VV42)
Organism: Homo sapiens (Human)
Function: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23048041}; Single-pass membrane protein {ECO:0000255}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. {ECO:0000269|PubMed:23048041}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A8
- Hematopoietically-expressed homeobox protein HHEX
- Insulin-like growth factor 2 mRNA-binding protein 2
- Transcription factor 7-like 2
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- ATP-sensitive inward rectifier potassium channel 11
- MMS19 nucleotide excision repair protein homolog
- Potassium voltage-gated channel subfamily KQT member 1
- Melatonin receptor type 1B
- A disintegrin and metalloproteinase with thrombospondin motifs 9
Sequence:
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
Protein: ESX-5 secretion system ATPase EccB5 (EC 3.6.-.-) (ESX conserved component B5) (Type VII secretion system protein EccB5) (T7SS protein EccB5) (P9WNQ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:B2HST3}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- ESX-5 secretion system protein EccD5
- ESX-5 secretion system protein EccC5
- ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein
- Mycosin-5
- ESX-5 secretion system protein EccE5
- ESX-3 secretion system protein EccD3
- ESX-3 secretion system protein EccC3
- ESX-4 secretion system protein eccD4
- ESX-4 secretion system protein EccC4
- ESX-3 secretion system protein EccE3
Sequence:
MAEESRGQRGSGYGLGLSTRTQVTGYQFLARRTAMALTRWRVRMEIEPGRRQTLAVVASVSAALVICLGALLWSFISPSGQLNESPIIADRDSGALYVRVGDRLYPALNLASARLITGRPDNPHLVRSSQIATMPRGPLVGIPGAPSSFSPKSPPASSWLVCDTVATSSSIGSLQGVTVTVIDGTPDLTGHRQILSGSDAVVLRYGGDAWVIREGRRSRIEPTNRAVLLPLGLTPEQVSQARPMSRALFDALPVGPELLVPEVPNAGGPATFPGAPGPIGTVIVTPQISGPQQYSLVLGDGVQTLPPLVAQILQNAGSAGNTKPLTVEPSTLAKMPVVNRLDLSAYPDNPLEVVDIREHPSTCWWWERTAGENRARVRVVSGPTIPVAATEMNKVVSLVKADTSGRQADQVYFGPDHANFVAVTGNNPGAQTSESLWWVTDAGARFGVEDSKEARDALGLTLTPSLAPWVALRLLPQGPTLSRADALVEHDTLPMDMTPAELVVPK
Protein: Volume-regulated anion channel subunit LRRC8C (Leucine-rich repeat-containing protein 8C) (Q498T9)
Organism: Rattus norvegicus (Rat)
Function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28833202}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TDW0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TDW0}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000250|UniProtKB:Q8TDW0}.
Interaction partners:
- Volume-regulated anion channel subunit LRRC8A
- Protein tweety homolog
- Protein tweety homolog
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
Sequence:
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQTVINTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEGSLVKSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVREQMKAD