wanglab/gogpt-training-data huggingface dataset:
Protein: NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf) (Q3UP24)
Organism: Mus musculus (Mouse)
Function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22885697}. Inflammasome {ECO:0000269|PubMed:21874021, ECO:0000269|PubMed:21918512, ECO:0000269|PubMed:26585513}.
Interaction partners:
- Caspase-1
- NACHT, LRR and PYD domains-containing protein 1a
- Baculoviral IAP repeat-containing protein 1a
- NACHT, LRR and PYD domains-containing protein 1b allele 2
- NACHT, LRR and PYD domains-containing protein 6
- Baculoviral IAP repeat-containing protein 1e
- Interferon-inducible protein AIM2
- Pyrin
- Apoptosis-associated speck-like protein containing a CARD
- NACHT, LRR and PYD domains-containing protein 3
Sequence:
MNFIRNNRRALIQRMGLTVTKQICDDLFALNVLNNQEANVIYCEPLEQEAARKIIHMTMQKGSAACNLFLKSLENWDYFVYQDLTGQNLSYQVTEEDLNVLAQNLKDLYNSPAFLNFYPLGEDIDIIFNLEKTFTEPIMWKKDHRHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVITCAIQMGRQEFQAHTQTMLFQTFYDLLIQKNSHRYRGGASGDFARSLDYCGDLALEGVFAHKFDFEPEHGSSMNEDVLVTIGLLCKYTAQRLKPTYKFFHKSFQEYTAGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYTCGSSTEATRAVMRHLAMVYQHGSLQGLSVTKRPLWRQESIQSLRNTTEQDVLKAINVNSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFVKLDFYERATESQDKAEENVPGVHTEGPSETYIPPRAVSLFFNWKQEFKTLEVTLRDINKLNKQDIKYLGKIFSSATNLRLHIKRCAAMAGRLSSVLRTCKNMHTLMVEASPLTTDDEQYITSVTGLQNLSIHRLHTQQLPGGLIDSLGNLKNLERLILDDIRMNEEDAKNLAEGLRSLKKMRLLHLTHLSDIGEGMDYIVKSLSEESCDLQEMKLVACCLTANSVKVLAQNLHNLIKLSILDISENYLEKDGNEALQELIGRLGVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLKNWRLRDEEIKSLGEFLEMNPLRDLQQLDLAGHCVSSDGWLYFMNVFENLKQLVFFDFSTEEFLPDAALVRKLSQVLSKLTLLQEVKLTGWEFDDYDISAIKGTFKLVTA
Protein: RNA-splicing ligase RtcB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) (P46850)
Organism: Escherichia coli (strain K12)
Function: GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
Interaction partners:
- RNA 3'-terminal phosphate cyclase
- Transcriptional regulatory protein RtcR
- Multifunctional CCA protein
- RNA 2',3'-cyclic phosphodiesterase
Sequence:
MNYELLTTENAPVKMWTKGVPVEADARQQLINTAKMPFIFKHIAVMPDVHLGKGSTIGSVIPTKGAIIPAAVGVDIGCGMNALRTALTAEDLPENLAELRQAIETAVPHGRTTGRCKRDKGAWENPPVNVDAKWAELEAGYQWLTQKYPRFLNTNNYKHLGTLGTGNHFIEICLDESDQVWIMLHSGSRGIGNAIGTYFIDLAQKEMQETLETLPSRDLAYFMEGTEYFDDYLKAVAWAQLFASLNRDAMMENVVTALQSITQKTVRQPQTLAMEEINCHHNYVQKEQHFGEEIYVTRKGAVSARAGQYGIIPGSMGAKSFIVRGLGNEESFCSCSHGAGRVMSRTKAKKLFSVEDQIRATAHVECRKDAEVIDEIPMAYKDIDAVMAAQSDLVEVIYTLRQVVCVKG
Protein: Protein MRH1 (Membrane protein related to HSP30) (Q12117)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane; Multi-pass membrane protein. Mitochondrion. Bud. Note=Localized primarily to the plasma membrane. Also found at the buds.
Interaction partners:
Sequence:
MSTFETLIKRGGNEAIKINPPTGADFHITSRGSDWFWTCFCCYLLFGLILTFLMFRKPVNDRFFYLTGIAPNFFMCIAYFTMASNLGWIPVKAKYNHVQTSTQKEHPGYRQIFYSRFVGWFLALPWPIIQICMLAGTPFWQMAFNVCITEFFTVCWLIAACVHSTYKWGYYTIGLGAAIVVSISVMTTSYNLVKQRDNDIRLTFLVFFSIIMFLWIIAYPTCFGITDGGNVLQPDSAGIFYGIIDLILMCFIPTLLVPIANHFGADKLGYHFGPSDAEAVMAPKAPVASPRPAATPNLSKDKKKKSKKSKKSKKSKKSEE
Protein: 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (Q90611)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Interaction partners:
- Metalloproteinase inhibitor 2
- Collagen alpha-1
- Proheparin-binding EGF-like growth factor
- Metalloproteinase inhibitor 3
- Transforming growth factor beta-1 proprotein
- Actin, cytoplasmic 1
- Decorin
- LRRNT domain-containing protein.
- Signal peptide, CUB domain and EGF like domain containing 3.
- Link domain-containing protein.
Sequence:
MKTHSVFGFFFKVLLIQVYLFNKTLAAPSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFKVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTKDFDADGKYGFCPHESLFTMGGNGDGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFIFLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIKGIQELYEVSPDVEPGPGPGPGPGPRPTLGPVTPELCKHDIVFDGVAQIRGEIFFFKDRFMWRTVNPRGKPTGPLLVATFWPDLPEKIDAVYESPQDEKAVFFAGNEYWVYTASNLDRGYPKKLTSLGLPPDVQRIDAAFNWGRNKKTYIFSGDRYWKYNEEKKKMELATPKFIADSWNGVPDNLDAVLGLTDSGYTYFFKDQYYLQMEDKSLKIVKIGKISSDWLGC
Protein: AP2 domain transcription factor (C6KSN9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MEDNLVKESNEIIGSCTVDGVHSSIMQKNMCSSDIILDDTNSKSLCDSNKLKKDNEKGIDENIKETSTCTYTVDENVMKSNEEKNDEDDDGSNNVDVVGDNIGNLPNENMDNRNNNDNNNINNNIQYDNVNNNNNINNNDSGGYSHSNDILNSNINQIVPFVNNANNEEQNKMREHIGSQEPVILIDKIERCLVVEWYENNIRREQRISYKKYGNDKAKLRAKELIEKLKSGITFEQLYPDKGPPIVRVFENVGVYNVSLIRDRIEREWRVEWLENGVPMKARWSCKKVGNDEAQKRADTFAQSMIKGIFNPILLHKATGTRFSRSDKSVVKINVYMNKNIKCLTNGIEDDLNTDHHHHHHNNNNNNCVKTFSIKGEVPSSTLNHKVTRSYRRRKKKNDINNTMEIQDGNVRSMTYLVNNNSSYLNHSNNMNPNLCNMNLMDYQMNEMYQGNNMSNMMLLDNNMKNMIHHNNVNNDLLLNSDLYNDKKRTRSSRTTRKRNICKTEKSMITKNGNKYMINNDKNIQMNKNDILVNTYLVKNELCNNYQNEPNNNNNNNNNNIMMMMNNNKKKVKTQLNNNIKNSYYIPSEQYEMFCSANNIVSGNRNKRANKSAYKITKNNKNNDFVNYNNISNTIPDNVTDEVQNYQYMLNDNMNGEYLNLNEYPMRNTEDGVDNYYQNKNYYYLYNNNNGMLVKTYVVDQEGNHNLVKNNNFVKIENTDYLYGGTSTNKCQPIADKRINNNYDSSSNKYKQNMLEYNNNYNLNVDKKGMNFTGSVSSLDAKKKKRKNSRSSKNRNTLETPYDNYTINYNVTCTKDKRGKNKKDTCENINDNIYENRNNDENLVGAKRRTKRVIATRKKKNARGKYKNNDNEDNNDIDGNEKNIGNEKDKENYEEKIEQGYIKEEYIVHGCEEEVKGLEENKGRKRRRIKSSKFYDNDEYIYSLDKTYNKKKASQYNNNNNDNNNDNNDNNNNNNNDNNNYGNTMVQNEFNRYFMNNNNYMVMNNMHTNNMLNNEGHYLNNNIYCKNEMQNVSFNNISRENMNMMNIPNMVNMNNLTNINSAYNVKTIENYNNGDKMNNPSFVNNCIEFVENPRGYRVPYEYQSQRFYEYFEVPLNSRKEFEMQQKYFANLFSLHILAVGWNVNKGDGMENNNIPQLTDQNMIPNGNNNNNNNTYELVPYNEKENIMNNKELLSSKEQINGPYIPYNYKPIYHVEPFSSDVNNNMNSNCNYYIDLENMNSTKIDGKEYTYNEVQTMNNYRAINKKESLENVANYENMMNYDNISNYNNPDDVINQRSNVANISDHNNNLNNISAVNDVHNIIDKNNMNHIPYYNDMNNNITNYANMTGIQNLNNMNPIMIDPNNNADSVEEFYDAIDGCNVVDTNYMVGTNNMIDQIHFNDVTSNVGNMNNNLTNFSNPYNSVKVINDLNNTGEMNNNMIHLNNKNEMTGLGNMNDNVHINNASVIKENGNSNSSKEMNHMNMEKLYVSQMNYSTNDLIHMNNNNNKNNNNNKNNNNNNNNNNNSNVNVVGIENSVNSTVYDNMNNYIPMNTINVNYMNDSRSDLMNGKNNINVEYKNVRGYDETLSNRSDMISYNMSGLDHFNDNRYRNDMDPLGKTNILNNHNNIGSVNIYNNQTDLINNYFNNNNNNNNNKYANINSSDMYKEQYYNTHMNHLINDNKEISNNFDDSKKNVKGITNGDNKDLLNVHNNANIKINNTCNINDTSNMLQENNIATNKKDLQVINKNMVLTYTCNNDDMINSLNGVNDLSNDPNDGSLKENRKNEPSFINTNVNVNVNNTNKNKVNGDNDIESNTLLGEDNNKINEKTIHSNSIYKNCNGSSDDANVPYENSDHLYFMEKEKYASDNVVNRNAHNQFKDSYYNLLSNEDVNNNITNENNNNSDDMSCNQYMKKNNNTSNKIIKEMNNYDFYSNKKMIDKLRSTSNSSTINTEYLPSNLLNSISINNVSQSNQINEHVDK
Protein: Probable calcium-binding protein CML44 (Calmodulin-like protein 44) (Q9LPK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- F14J8.16 protein
- Calcium-binding protein CML39
- Probable calcium-binding protein CML33
- Calcium-binding protein CML38
- Probable calcium-binding protein CML34
- Probable calcium-binding protein CML14
- Probable calcium-binding protein CML50
- Probable calcium-binding protein CML40
- RING-H2 finger protein ATL60
- Calcium-binding protein CML19
Sequence:
MDCSFITTNDLRRMFKTLDKNQDGLVTLDELLWILDKLGWAEHTPDELELIVGKQSLDLDEFLRFYYDAVLDSKGSKKNIDVVADNDEAIARAFNVFDVNGDGYISAEELRDVLERLGFEEEAKAWDCGRMIRVHDKNLDGFVDFEEFKNMILHV
Protein: 14-3-3-like protein GF14-12 (Q01526)
Organism: Zea mays (Maize)
Function: Is associated with a DNA binding complex to bind to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
Interaction partners:
Sequence:
MASAELSREENVYMAKLAEQAERYEEMVEFMEKVAKTVDSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEEGRGNEDRVTLIKDYRGKIETELTKICDGILKLLESHLVPSSTAPESKVFYLKMKGDYYRYLAEFKTGAERKDAAENTMVAYKAAQDIALAELAPTHPIRLGLALNFSVFYYEILNSPDRACSLAKQAFDEAISELDTLSEESYKDSTLIMQLLHDNLTLWTSDISEDPAEEIREAPKHDLSEGQ
Protein: glutathione-specific gamma-glutamylcyclotransferase (EC 4.3.2.7) (Q57YD2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Glutathione synthetase
- Glutathione peroxidase
- Cytosolic leucyl aminopeptidase, putative
- Trypanothione synthetase, putative
- Protein kinase, putative
Sequence:
MRAEKVTVSPAGEGAAPLFVFGYGSILWKQQFEYLRALPCCVHGYKRVFYQGSTDHRGVPARPGRVVTLLTCGDPEAWVGGVAFELPVEEEKREKILAQLDDRESGGYEREEVTLYDIKTHERLHLPPGAVCLCYRATEDNPEYLGEAKDEAIAEQILSCEGLSGPNSEYLFKLAEALRKLESADQHVFAVETAALHIMKAQNVPE
Protein: At2g36220/F2H17.17 (Expressed protein) (Q9SJN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPQVDIEAFVSSVCIGGSDHRKIVCETLADDSTIPPYYNNSAVSPSDFPPESYFLSNDAQLEWLSDNAFFDRKDSQKGNSGILNSNPNSNPSSQRFLLKSKASIIGLPKPQKTCFNEAKQRRHAGKNRVILKRVGSRIKTDISLLEPSSPKVSCIGRVRSRRERSRRMHRQKSSRVEPVNRVKKPGFMASFRAIFRIKGGCKDVSARETHTSTRNTHDIRSRLPAEADEKSVFDGGEPVVPGLGGMTRFASGRRADLLGGGGC
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (J3QRU1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLDLIMGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
Protein: Vimentin (P02544)
Organism: Mesocricetus auratus (Golden hamster)
Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08670}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08670}. Nucleus matrix {ECO:0000250|UniProtKB:P31000}. Cell membrane {ECO:0000250|UniProtKB:P20152}.
Interaction partners:
- H-2 class II histocompatibility antigen, E-U alpha chain
- Rano class II histocompatibility antigen, A beta chain-like
- Desmin
- Glial fibrillary acidic protein
- Barrier-to-autointegration factor
- Immunoglobulin lambda-like polypeptide 5.
- Nestin
- HLA class II histocompatibility antigen, DO beta chain
- HLA class II histocompatibility antigen, DO alpha chain isoform X1
- Caspase-7
Sequence:
MSTRSVSSSSYRRMFGGPGTSNRQSSNRSYVTTSTRTYSLGSLRPSTSRSLYSSSPGGAYVTRSSAVRLRSSMPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAESTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHDEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESNEYRRQVQSLTCEVDALKGTNESLERQMREMEENFALEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLESLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
Protein: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (Q387Q3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenylosuccinate synthetase
- GMP synthase
- AMP deaminase
- Adenosine monophosphate deaminase, putative
- AMP deaminase, putative
- Adenylosuccinate lyase
- Hypoxanthine phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
- Inosine-5'-monophosphate dehydrogenase
- Nucleoside diphosphatase, putative
Sequence:
MDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVRSVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLLGIVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGYLPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKGRVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQDQAKNLIDAGADSLRIGMGSGSICITQEVLACGRPQATAIYKVARYAASRGVPCVADGGLRNVGDVCKALAVGANVAMLGSMIAGTSETPGEYFFKDGMRLKGYRGMGSIDAMLQGRESGKRYLSENETLQVAQGVAGAVLDKGSVLKLLAYIHKGLQQSAQDIGEVSFDAIREKVYEGQVLFNRRSLTAQSEGAVHSLHHYERKLFASKL
Protein: Ras-related protein RSR1 (EC 3.6.5.2) (P52498)
Organism: Candida albicans (Yeast)
Function: Ras-related protein which binds GDP/GTP and possesses intrinsic GTPase activity (By similarity). Involved in both yeast and hypha development. In the yeast phase, it is required for normal (polar) bud site selection and is involved in cell morphogenesis; in the yeast-mycelial transition it is involved in germ tube emergence; and in the development of the hyphae it is involved in cell elongation.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
Sequence:
MRDYKVVVLGAGGVGKSSITVQFVQGVYVESYDPTIEDSYRKQIEVDGRACDLEILDTAGVAQFTAMRELYIKSGKGFLLVYSVTDENSLKELLALREQVLRIKDSDNVPMVLVGNKCDLEDDRVLSIEDGVKVSQDWGLVPFYETSAMYKTNVDEAFIDVVRQIMRKEAAISAEKKQQKELQKQQQQQQQEQDAEGQQQQQKSGKSKSSATQKDATADGQTDVNARLKQSINDHPKSSSGSKFCTII
Protein: Cadherin C-terminal catenin-binding domain-containing protein (Q8BRP3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
PDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Forkhead box protein D3-B (FoxD3-B) (FoxD3b) (Fork head domain-related protein 6') (xFD-6') (Q9DEN3)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor that is an essential upstream regulator of neural crest determination and mesoderm induction. Functions by recruiting the transcriptional corepressor tle4. Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MTLSSSGSASDMSGQTVLSADDADIDVVGEGDEALDKDSECESPVGHHDEVDALGGKEIPRSPSGSSTDAEGKGESQQQQQEGIQNKPKNSVVKPPYSYIALITMSILQSPQKKLTLSGICEFISSRFPYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRQQQDTLREQTALMMQSFGAYSLASPYGRHYGLHPAAYTHPAALQYPYIPPVGPMLPPAVPLLPSSELTRKAFSSQLSPSLQLQLSSLSSTAASIIKSEPSSRPSFSIENIIGVSAASSVAPQTFLRPPVTVQSALMSHQPLVLSRSTAAIGPILSVPTNLISGQFLPTAATAVAKWPAQ
Protein: Glutathione S-transferase (EC 2.5.1.18) (A0A140VKE2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAKLALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
Protein: DNA-3-methyladenine glycosylase II (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (Q1W6H1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
Protein: Repressed By RIM101 protein 1 (Predicted GPI-anchored protein 20) (Q5A6M0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Probable cell wall protein required for filamentation at low pH.
Subcellular location: Secreted, cell wall {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MKFSTTLLALTASIAAVMSADSSAAASGAASAASGAKSGATSAASGAKSGASSVASAAKSGVSSAASAAKSGASSATGGSSAAKSGSSSGAGFAPVAGAGSLAAIAGLLLL
Protein: Transcription factor SOX-11 (Q7M6Y2)
Organism: Mus musculus (Mouse)
Function: Transcription factor that acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron. Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:15456859}.
Interaction partners:
- Sulfhydryl oxidase 1
- POU domain, class 3, transcription factor 3
Sequence:
MVQQAESSEAESNLPRDALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKTDPAAKPSAGQSPDKSAAGAKAAKGPGKKCAKLKAPAGKAGAGKAAQPGDCAAGKAAKCVFLDDDDEDDDEDDELQLRPKPDADDDDDEPAHSHLLPPPTQQQPPQLLRRYSVAKVPASPTLSSAAESPEGASLYDEVRAGGRLYYSFKNITKQQPPPAPPALSPASSRCVSTSSSSGSSSGSGAEDADDLMFDLSLNFSQGAHSACEQPLGAGAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY
Protein: LD20458p (Nicotinic acetylcholine receptor alpha4, isoform E) (Q95RL8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYIDSAYNVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFSGTSAGRCRPPQ
Protein: Sodium/hydrogen exchanger 2 (H7) (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) (P48763)
Organism: Rattus norvegicus (Rat)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q9UBY0}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the brush-border membrane throughout the intestinal tract. {ECO:0000269|PubMed:7685026}.
Interaction partners:
- Chloride anion exchanger
- Sodium bicarbonate cotransporter 3
Sequence:
MGPSGTAHRMRAPLSWLLLLLLSLQVAVPAGALAETLLDAPGARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENLGTIFWYAVVGTLWNSIGIGLSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSLNRERRASTSTSRYLSLPKNTKLPEKLQKKNKVSNADGNSSDSDMDGTTVLNLQPRARRFLPDQFSKKASPAYKMEWKNEVDVGSARAPPSVTPAPRSKEGGTQTPGVLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP
Protein: Mitochondrial import receptor subunit TOM20-2 (Translocase of outer membrane 20 kDa subunit 2) (P82873)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:14730085, ECO:0000269|PubMed:17981999, ECO:0000269|PubMed:31118221}; Single-pass membrane protein {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:14730085, ECO:0000269|PubMed:17981999}.
Interaction partners:
- Mitochondrial import receptor subunit TOM9-2
- Mitochondrial import receptor subunit TOM20-3
- Mitochondrial import receptor subunit TOM20-4
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Mitochondrial import inner membrane translocase subunit TIM44-1
- Mitochondrial import inner membrane translocase subunit TIM17-2
- Mitochondrial import receptor subunit TOM40-1
- Outer envelope pore protein 24A, chloroplastic
- Mitochondrial import receptor subunit TOM9-1
- Succinate dehydrogenase subunit 7B
Sequence:
MEFSTADFERLIMFEHARKNSEAQYKNDPLDSENLLKWGGALLELSQFQPIPEAKLMLNDAISKLEEALTINPGKHQALWCIANAYTAHAFYVHDPEEAKEHFDKATEYFQRAENEDPGNDTYRKSLDSSLKAPELHMQFMNQGMGQQILGGGGGGGGGGMASSNVSQSSKKKKRNTEFTYDVCGWIILACGIVAWVGMAKSLGPPPPAR
Protein: Alpha-1-antitrypsin-related protein (AAT-related protein) (Protease inhibitor 1-like) (Serpin A2) (P20848)
Organism: Homo sapiens (Human)
Function: Putative serine protease inhibitor.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:23826168}.
Interaction partners:
Sequence:
MPFSVSWGILLLAGLCCLVPSSLVEDPQEDAAQKTDTSHHDQGDWEDLACQKISYNVTDLAFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRTEILEGLNVNLTETPEAKIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTEEAKEQINNYVEKRTGRKVVDLVKHLKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDKTIIRVPMINHLGRFDIHRDRELSSWVLAQHYVGNATAFFILPDPKKMWQLEEKLTYSHLENIQRAFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQEAPLKLSKAVHVAVLTIDEKGTEATGAPHLEEKAWSKYQTVMFNRPFLVIIKDDITNFPLFIGKVVNPTQK
Protein: Fucolectin-3 (Q9I929)
Organism: Anguilla japonica (Japanese eel)
Function: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:10924498}.
Interaction partners:
Sequence:
MEVKMIILLFQILAISTLKSDSADIPEGYIQENVALRGRATQSAQLKGEFAGFAHASNAIDGNRDSNYHHGSCSHTEGDNSWWRVDLKQVYTITSVTITNRGDCCGERISGARILIGKHLENNGINNPECSTINIMAAGETKTFHCPQPMIGRYVTVYLPKAESLQLCEVEVNVLFPAPC
Protein: Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) (P34900)
Organism: Rattus norvegicus (Rat)
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Syndecan-4
- Glypican-1
- Syndecan-1
- Ezrin
- Peripheral plasma membrane protein CASK
- Fibronectin
- Radixin
- Moesin
- Fibroblast growth factor 2
- Transforming growth factor beta-1 proprotein
Sequence:
MQRAWILLTLGLMACVSAETRAELTSDKDMYLDSSSIEEASGLYPIDDDDYSSASGSGAYEDKGSPDLTTSQLIPRISLTSAAPEVETMTLKTQSITPTQTESPEETDKKEFEISEAEEKQDPAVKSTDVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA