wanglab/gogpt-training-data huggingface dataset:
Protein: Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (Q1PS67)
Organism: Oryzias latipes (Japanese rice fish) (Japanese killifish)
Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O14746}. Chromosome, telomere {ECO:0000250|UniProtKB:O14746}.
Interaction partners:
- Nucleolar protein 10
- H/ACA ribonucleoprotein complex subunit 2
- Protection of telomeres protein 1
- Uncharacterized protein
- Shelterin complex subunit TPP1/Est3 domain-containing protein
- X-ray repair cross-complementing protein 5
- DNA helicase
- H/ACA ribonucleoprotein complex subunit DKC1
- Telomerase-binding protein EST1A
- Nonsense-mediated mRNA decay factor
Sequence:
MTSGDLSSVLNILRSLYKRTRTLEEFADGVVFREGRRAALLQPSDTHSFKSFVRGVFVCSDEELQDVPSCNQTCTFPELLAFILNSLKRKRRRNVLAHGYNFLGVAQEDRDADHFRFQGDLSQSAAYIHSSDLWKKVTARLGTDVTRYLLGSCSVFVLAPPSCVFQICGVPAYDRVSMTTASSGFLLRPPSRKHKSFQVGKKTRSANLTKTGSVGDVEESRKRRRVESEVSTRKRKRESEEEESRERRRGVHHEERRQHEAVLDESTLSGKSGENDAAAVKPPPETSAAPPPLEGGPSWRSGAFPPLPSSQCFIRTLGFLYGGRGMHGFCLNRKRRTAAGPRRLQGQDLVRLVFFEGLPYLNGQERKPKKLPLRYFNMVPVFGRLLQRHRKCRYSSVLHRMCPVVELSRAAQGELSSLIPQHCAPHRVYLFVRECLTAVVPEELWGSDHNRLQFFSRVRGFLKSGKFERISVAELMWKIKVMDCDWLKLRRTAGRFPPSELAYRTRILSQFLTWLLDGFVVGLVRACFYATESVGQKNAIRFYRQEVWSKLQDLAFRRHIAKGEMEELSPAQVASLPKGTVISQLRFIPKTDGMRPITRVIGADSNTRLHHKRIRDLMSMLQARVRSAPALLGSTVWGMTDIHKVLRSLAPAQKDKPQPLYFVKVDVSGAYDSLPHDKLKEVITEALSPVQEEVFTVRHYAKIWADSHEGLKKAFARQVDFSDGSMGSTSMKGFVMSLQKSSKVHHAVLVEQAFGSNLRGKDALQFFTQMLTGSVVQHGKKTYRQCRGIPQGSVVSSLLCCLCYGHMENVLFRDIKNKGWLMRLVDDFLLITPDRNQAQSFLSILLAGVPQYGVVANPQKVVVNFQGSEGGGAFPDIRVLPPHCLFPWCGLLLDTRSLDVCKDYSSYAGLSLRYSLTLGSAHSAGQQMRRKLMSILRIKCHPLFLDLKTNSLESAYKNIHKLVLLQACRFHVCVQSLPFAQTVAKNPTYFQQMIWDMAHYANALIRRSNTGLVLGDGAQKGSVQYEAVELLFCLAFLRVLSKHRPVYKDLLPRLHKWKRRLERLLGDLRLARVRQAANPRALLDFLAMQM
Protein: MYND-type domain-containing protein (Q57XS7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPSNNSSNTSSLPLPPRPDPVTLDQIFDRLTAPYVAMEDRAYHLVALYTVAFHPSVKLFLFEHEPLRNTDATGVMGYSEENTRRREALLKGIAFFLAQRSNAVAQECRWETAALLGELCRMESVQPLRSAGANDRNSTSSINAISGARSYGIFSPKEEVVQKINHYARANLEYLARLPWFVIAVRELIGNEGDVNSAPKTTTSSLELRRALRQRLRRSVDSDGCGLNDDNGQTNLSSGVECDDDTRVALKDILAALPDIVTAEEAPDEGTATLSQTTVVRWSAEQLERACDLMFVDASTTLLHLIPLVSRSSHLLCANCQKHGVKCGGEGLLRCSSCKAVYYCSEECQREHWSAAHRVPCKNYKQRAETILAEYIAANKNVVGGKRGKRMSLQQQEELVAVLEVPLEPSLFYETRRYLYDHRDASFSGVSFYDYFMKYTVRGS
Protein: Origin recognition complex subunit 4 (O88708)
Organism: Mus musculus (Mouse)
Function: Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus.
Interaction partners:
- Origin recognition complex subunit 2
- Origin recognition complex subunit 5
- Cell division control protein 6 homolog
- Origin recognition complex subunit 3
- Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- DNA replication factor Cdt1
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM3
Sequence:
MSSRKTKSNAHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVVEDKVFGSFAENLSFLLEALQKGDRTSSCPVIFILDEFDIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFDFPQYLKIFKEQLSLPAEFPDKAFAERWNENVHCLSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL
Protein: Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) (RING-type E3 ubiquitin transferase BIRC3) (O08863)
Organism: Mus musculus (Mouse)
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- TNF receptor-associated factor 2
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Diablo IAP-binding mitochondrial protein
- TNF receptor-associated factor 3
- TNF receptor-associated factor 1
- Receptor-interacting serine/threonine-protein kinase 1
- Myeloid differentiation primary response protein MyD88
- Baculoviral IAP repeat-containing protein 2
- Tumor necrosis factor receptor superfamily member 1A
- Mitogen-activated protein kinase kinase kinase 7
Sequence:
MVQDSAFLAKLMKSADTFELKYDFSCELYRLSTYSAFPRGVPVSERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGYFSGSYSSFPSDPVNFRANQDCPALSTSPYHFAMNTEKARLLTYETWPLSFLSPAKLAKAGFYYIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFLKDLGQSASRYTVSNLSMQTHAARIRTFSNWPSSALVHSQELASAGFYYTGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQVQAGYPHLLEQLLSTSDSPEDENADAAIVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQWQILATGENYRTVSDLVIGLLDAEDEMREEQMEQAAEEEESDDLALIRKNKMVLFQHLTCVTPMLYCLLSARAITEQECNAVKQKPHTLQASTLIDTVLAKGNTAATSFRNSLREIDPALYRDIFVQQDIRSLPTDDIAALPMEEQLRKLQEERMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS
Protein: Heat shock 70 kDa protein 9, mitochondrial (Chaperone protein HscA homolog 1) (AtHscA1) (Heat shock protein 70-9) (AtHsp70-9) (Mitochondrial heat shock protein 70-1) (mtHsc70-1) (Q8GUM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chaperone involved in the maturation of iron-sulfur [Fe-S] cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HSCB and ISU1. In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19865480, ECO:0000305|PubMed:25732537}. Cytoplasm, cytosol {ECO:0000269|PubMed:19865480}.
Interaction partners:
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Iron-sulfur cluster assembly protein 1
- Chaperonin CPN60-like 1, mitochondrial
- Iron-sulfur cluster assembly protein 3
- Heat shock 70 kDa protein 10, mitochondrial
- Iron-sulfur cluster assembly protein 2
- Chaperonin CPN60-like 2, mitochondrial
- Chaperonin CPN60, mitochondrial
- Chaperonin 60 subunit beta 4, chloroplastic
- Chaperone protein dnaJ GFA2, mitochondrial
Sequence:
MASVALLRSFRRREVQMASVSAFKSVSANGKNSMFGKLGYLARPFCSRPVGNDVIGIDLGTTNSCVSVMEGKTARVIENAEGSRTTPSVVAMNQKGELLVGTPAKRQAVTNPTNTIFGSKRLIGRRFDDPQTQKEMKMVPYKIVKAPNGDAWVEANGQKFSPSQIGANVLTKMKETAEAYLGKSINKAVVTVPAYFNDAQRQATKDAGKIAGLDVQRIINEPTAAALSYGMNNKEGVIAVFDLGGGTFDVSILEISSGVFEVKATNGDTFLGGEDFDNTLLEYLVNEFKRSDNIDLTKDNLALQRLREAAEKAKIELSSTTQTEINLPFITADASGAKHLNITLTRSKFEGLVGKLIERTRSPCQNCLKDAGVTIKEVDEVLLVGGMTRVPKVQEIVSEIFGKSPCKGVNPDEAVAMGAAIQGGILRGDVKDLLLLDVVPLSLGIETLGAVFTKLIPRNTTIPTKKSQVFSTAADNQMQVGIKVLQGEREMAADNKVLGEFDLVGIPPAPRGMPQIEVTFDIDANGITTVSAKDKATGKEQNITIRSSGGLSDDEINRMVKEAELNAQKDQEKKQLIDLRNSADTTIYSVEKSLSEYREKIPAEIASEIETAVSDLRTAMAGEDVEDIKAKVEAANKAVSKIGEHMSKGSGSSGSDGSSGEGTSGTEQTPEAEFEEASGSRK
Protein: Protein CTLA-2-beta (Cytotoxic T-lymphocyte-associated protein 2-beta) (P12400)
Organism: Mus musculus (Mouse)
Function: Not known, expressed in activated T-cell.
Interaction partners:
- Protein CTLA-2-alpha
Sequence:
MMSAAPSPDPSLDNEWKEWKTTFAKAYSLDEERHRRLMWEENKKKIEAHNADYERGKTSFYMGLNQFSDLTPEEFRTNCCGSSMCRGEMAPDLPEYEDLGKNSYLTPGRAQPE
Protein: Meiotic expression up-regulated protein 18 (Q9UUB3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized membrane protein C1919.04
- Uncharacterized membrane protein C70.04c
- Meiotic chromosome segregation protein C17A2.07c
- Meiotic expression up-regulated protein 23
- Uncharacterized protein C18G6.13
- Meiotic expression up-regulated protein 1/2
- Meiotic coiled-coil protein 2
Sequence:
MIYINFYELYNIKNIRPLIPSFHVCLLIMFLILYSQEILSFFFMCSKFSMNSLKFCVLFSFKTVYSLLKLIKTLIRKLLYCFHYALDLFADEYKVTANDKHYDYRLKSHRIKDKITTKCKGTTKYFNSRHFEIKNAVENLPSFSSNLTTIGNNLRIFWKNGKIRCIKLTCTPDAEIVNFTSNPNRYRFYETNMQELIRKTICEKSDKAIEKTFLCAQLFKTFCEDGVLQTFQPGFIQLDIASNLQEIKKGTKEYSLKSLEMTTTKESNETLCSNDSKHRIARLKNEDNTQKPISKKRKSKKASHKYLSSRTAPNVDFGNFAKERHRENDVSELYSKTKRTSKIRELYKEIGYDKNEFIHELRENEGPSVLYDSGLDQNGTNYDDAFAAPEAISIEKYVSINEEDPKSPKKETSYQVQEKLSQFFQEEMIHLLEMGEACTSRESQKTRKKNLKENIRKQRTTSTAIRDIAIKFLDDAKCETEDSTNLTNREGEAEKTLNTQPWKNLIENFISELQAEEEENNITEWSDIISVRNDEENQIYELPTCQLETNLLV
Protein: Calmodulin-7 (CaM-7) (P59220)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro. Required during nonhost resistance (NHR) to the nonadapted fungal pathogens Phakopsora pachyrhizi and Blumeria graminis f.sp. hordei, probably via its Ca(2+)-dependent interaction with ABCG36.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26315018}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus {ECO:0000269|PubMed:26315018}. Note=Co-localizes with ABCG36 at the cytoplasm/plasma membrane interface. {ECO:0000269|PubMed:26315018}.
Interaction partners:
- Mitogen-activated protein kinase 8
- Calcium-transporting ATPase 8, plasma membrane-type
- Plasma membrane-associated cation-binding protein 1
- Kinesin-like protein KIN-14E
- Calmodulin-binding transcription activator 3
- Cyclic nucleotide-gated ion channel 2
- Two pore calcium channel protein 1
- CDPK-related kinase 1
- Heat shock 70 kDa protein 4
- CBL-interacting serine/threonine-protein kinase 24
Sequence:
MADQLTDDQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
Protein: La ribonucleoprotein 4B (H0Y641)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSFELGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSPSPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATVRTSCLPSCTTAARLWCEQTLRTPAPARFLITSNLVGFYLRLSVLCFLYKIPLIFANNFPLTTLVLSQTTM
Protein: aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) (A0A1B0GV49)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
Protein: Metaxin 2 (C9JNK6)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
Sequence:
MSLVAEAFVSQIAGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYFEDRGKGRLS
Protein: Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23) (Q9BV35)
Organism: Homo sapiens (Human)
Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600, ECO:0000305|PubMed:15716113}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Calcium uptake protein 1, mitochondrial
- Mitochondrial calcium uniporter regulator 1
- Calcium uptake protein 2, mitochondrial
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 2
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Calcium uniporter regulatory subunit MCUb, mitochondrial
Sequence:
MRGSPGDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGGGNPDPGAQQGISSEGDADPDGGLDLEEFSRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALGVTSR
Protein: Fascin (Q6AXQ1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
Interaction partners:
- Transmembrane protein 225
Sequence:
MAEVDWIHRHPKAEALRVGLISWAGTYLTFEAYKSTVTATAKSLGRRQTWELLVSNEHETQAVVRLKSLQGLYLLCEADGTVCYGKPRTSHHGCFLLRFHRNGKWTLQCIISGRYLESDGQDVFCNSRVLSAYHMWTPRPALHVHVILYSPTYHSYARADHTVGRVWVDAAVPCLEECGFLLHFQDGCYHLETSTHHFLSRVDRLVPKRSTQTAFHMQVRPRGLVALCDGEGGSLYPQGSHLLLGLGSTPMKGEEWFVLQHFPAWVSLKSKSRRFLSVIYDAEVCAASERLTQMSLFQYECDSESPILQLRSANGFYLAQRRHRAIIADGHPMESDTFFRVHWNCGKITLQSPNGRFLSIASNGLLMSNVTIPGPNEELGIRFANRPFLVLRGRYGYVGSSSDHDLLKCNMDQPDCIQLLPCHQGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELQGSSLLTVLAPNGFYLRADRSGTLLADSEEITKECIWEF
Protein: Neurexin-2-beta (Neurexin II-beta) (P58401)
Organism: Homo sapiens (Human)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
Subcellular location: Presynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MPPGGSGPGGCPRRPPALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGARVSSSLSTTHHVHHFHSKHGTVPIAINRMPFLTRGGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Protein: Thrombospondin-3 (Q05895)
Organism: Mus musculus (Mouse)
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.
Interaction partners:
- Leukocyte surface antigen CD47
- Integrin alpha-V
- Platelet glycoprotein 4
- Integrin alpha-3
- Integrin beta-3
- Integrin beta-1
- Syndecan-4
- Syndecan-1
- Integrin alpha-IIb
- Integrin alpha-7
Sequence:
MEKPELWGVLALLLLCSYTCGSQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSRPSPGLQLYVDCKLGDQHAGLPALAPIPPAEVSGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDDSIHNAVTSALQSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPSPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCDDINECAHADPCFPGSSCINTMPGFHCEACPPGYKGTRVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCVPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVILDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSISGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWRLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV
Protein: CBS domain-containing protein CBSCBSPB5 (P0DH79)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- CBS domain-containing protein
- DUF21 domain-containing protein At4g14240
- Putative DUF21 domain-containing protein At3g13070, chloroplastic
- Pentatricopeptide repeat-containing protein At5g10690
- Probable arabinose 5-phosphate isomerase
- CBS domain-containing protein CBSX6
- GMP synthase
Sequence:
MANQGGPSRKSLSFSGHSFQGRKKASENEGGGGGGSDLLPRRSLTSSRSSISLSGERSGERTVKRLRLCKALTVPDSTTLFEACRRMAARRVDALLLTDSNALLCGILTDRDIATKVIAKQLNLEETPVSKVMTKNPVFVLSDTIAVEALQKMVQGKFRHLPVVENGEVIALLDIAKCLYDAIARMERSVEKGKAIAAAVEGVEKNWGTSIAGPNTFMETLRERIFKPSLSTIIPENTKVLKVGLDETVLGVTMKMVEYQSSAAMVMVENKLVGILTSKDILMRVISQNLPQETTTVEKVMTPNPESATVDMAIVEALHIMHNGKFLHLPVLDKDGDVVAVIDVIHITHAAVTTAGSTAGINNETANSMMQKFWDSAMALSPNEDGDETRSEEESMKLSSEIEVTKSFSYPNTFAFKLQDKKGRMHRFMCETQSLTTLITAILQRMGDDIEPDNLPQIMYEDEDNDKVVLASDNDLGAAVEHAKSIGWKGLKLHLDYTEERGHRRGLSSEDMDYDQSNSWAAAYKTVAAGAALAAGLGVLVYLKRNSN
Protein: Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Q56XP4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes. May also exchange Li(+) and Cs(+) with a lower affinity. Involved in vacuolar ion compartmentalization necessary for cell volume regulation and cytoplasmic Na(+) detoxification.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:12047628}; Multi-pass membrane protein {ECO:0000269|PubMed:12047628}. Note=Tonoplast.
Interaction partners:
- Sodium transporter HKT1
- Calcineurin B-like protein 4
- Pyrophosphate-energized vacuolar membrane proton pump 1
- Potassium channel SKOR
- Chloride channel protein CLC-c
- Potassium channel AKT1
- CBL-interacting serine/threonine-protein kinase 24
- Cation/H
- Potassium channel GORK channel)
Sequence:
MTMFASLTSKMLSVSTSDHASVVSLNLFVALLCACIVIGHLLEENRWMNESITALLIGLGTGVVILLISRGKNSHLLVFSEDLFFIYLLPPIIFNAGFQVKKKQFFRNFVTIMAFGAIGTVVSCTIISLGAIQFFKKLDIGTFDLGDFLAIGAIFAATDSVCTLQVLNQDETPLLYSLVFGEGVVNDATSVVLFNAIQSFDLTHLNHEAAFQFLGNFFYLFLLSTGLGVATGLISAYVIKKLYFGRHSTDREVALMMLMAYLSYMLAELFALSGILTVFFCGIVMSHYTWHNVTESSRITTKHAFATLSFLAETFIFLYVGMDALDIEKWRFVSDSPGTSVAVSSILMGLVMLGRAAFVFPLSFLSNLAKKHQSEKISIKQQVVIWWAGLMRGAVSMALAYNKFTRSGHTELRGNAIMITSTITVCLFSTMVFGMLTKPLIRYLMPHQKATTSTTSMLSDDSTPKSIHIPLLDGEQLDSFELPGSHQDVPRPNSLRGFLMRPTRTVHYYWRQFDDAFMRPVFGGRGFVPFVPGSPTERSSHDLSKP
Protein: Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) (Q9WTP0)
Organism: Rattus norvegicus (Rat)
Function: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Glutamate receptor 1
- Disks large homolog 1
- Glutamate receptor 4
- Disks large homolog 4
- PRKCA-binding protein
Sequence:
MTTETGPDSEVKKAQEETPQQPEAAAAVTTPVTPAGHSHPETNSNEKHLTQQDTRPAEQSLDMEEKDYCEADGLSERTTPSKAQKSPQKIAKKFKSATCRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDHDTEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKREDDAESGGRRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKASERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDAVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGGAFEDFSRSLPELDRDKSDSETEGLVFARDLKGPSSQEDESGGIEDSPDRGACSTPELPQFESVKAETMTVSSLAIRKKIEPEAMLQSRVSTADSTQVDGGAPAAKDFMTTPPCITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Protein: Dybowskin-1CDYa (B5A9S9)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide. Has activity against the Gram-positive bacterium S.aureus (MIC=6 uM) and the Gram-negative bacterium E.coli (MIC=3 uM). Lacks hemolytic activity against human erythrocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:19539775}.
Interaction partners:
Sequence:
MFTLKKSLLLLFFLGTINFSLCEEERNAEEERRDYPEERDVEVEKRIIPLPLGYFAKKT
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (EC 3.1.4.11) (F1SDV6)
Organism: Sus scrofa (Pig)
Interaction partners:
- Platelet-derived growth factor receptor beta
- Tyrosine-protein kinase SYK
- Receptor protein-tyrosine kinase
- Lymphocyte cytosolic protein 2
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor
- Proto-oncogene vav
- Tyrosine-protein kinase receptor.
- Protein kinase C
- Tyrosine-protein kinase.
Sequence:
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTELEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEETYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLVSYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAICVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVWPAKLFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKLDIFPVKQENSDLSPFGGTSLRERGYDISGQPAHGRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL