wanglab/gogpt-training-data huggingface dataset:
Protein: Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) (Q86X95)
Organism: Homo sapiens (Human)
Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Subcellular location: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Interaction partners:
- Recombining binding protein suppressor of hairless
- Histone deacetylase complex subunit SAP30
- SNW domain-containing protein 1
- Recombining binding protein suppressor of hairless-like protein
- Nuclear receptor corepressor 2
- Histone deacetylase 2
- Histone deacetylase 1
- Protein FRG1
- Pre-mRNA-splicing factor CWC25 homolog
- Spliceosome-associated protein CWC15 homolog
Sequence:
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE
Protein: Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (D3YXJ0)
Organism: Mus musculus (Mouse)
Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27643686}. Cell membrane {ECO:0000269|PubMed:27643686}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27643686}. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS. {ECO:0000250|UniProtKB:Q86XP1}.
Interaction partners:
Sequence:
MAGAGSQHHPQGVAGGAVAGASAVSPTAAGPGEDSSDSEAEQEGPQKLIRKVSTSGQMRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEVWISSLKSVQSREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDVYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPAKSSLLPEPVAATEEFYMTIYEDSVANHLTKIVNSDEHAVVISSAKILCETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHADSQASRVPPGIGPAIPEEDTVESASDESLGESKDQLVNDIGKPSSQKAVKPREIMLRANSLKKAVRQVIEEAEKVMDEPAVQPSEPVSPSCDYDTETDEAKEDDAKESLSAKTTSQSPDAQASCGHPQTDSVAGPAMATTKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTNLYIHPAPDLATEEVSQMRLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRFPESLTRDTATEIAINVKALYNETEALLVGRVPLHLESPHEERVSSALHSVEMELQKLTEIPWLYYILRPSEDEEPPLDCTKRNNKSTVFRIVPKFKKEKAQKQKTSSQPVQNWGTEEVAAWLDLLNLGEYKEIFIRHDVRGAELLHLERRDLKDLGIPKVGHMKRILQGIKELERNPPNLV
Protein: Aldehyde dehydrogenase, cytosolic 1 (EC 1.2.1.3) (ALDH class 1) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A7) (Aldehyde dehydrogenase phenobarbital-inducible) (P13601)
Organism: Rattus norvegicus (Rat)
Function: Can oxidize benzaldehyde, propionaldehyde and acetaldehyde. No detectable activity with retinal.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MSSPAQPAVPAPLANLKIQHTKIFINNEWHNSLNGKKFPVINPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGCLLNKLADLMERDRVLLATMESMNAGKIFTHAYLLDTEVSIKALKYFAGWADKIHGQTIPSDGDVFTYTRREPIGVCGQIIPWNGPLILFIWKIGAALSCGNTVIVKPAEQTPLTALYMASLIKEAGFPPGVVNVVPGYGSTAGAAISSHMDIDKVSFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDSAVEFAHQGVFFHQGQICVAASRLFVEESIYDEFVRRSVERAKKYVLGNPLDSGISQGPQIDKEQHAKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDEVIKRANNTPYGLAAGVFTKDLDRAITVSSALQAGTVWVNCYLTLSVQCPFGGFKMSGNGREMGEQGVYEYTELKTVAMKISQKNS
Protein: Mediator of RNA polymerase II transcription subunit 31 (Cell separation protein sep10) (Mediator complex subunit 31) (Soh1 homolog) (Q9USH1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 4
Sequence:
METKWLLSKVPDDKSRFEIELEFVQMLSNPWYLNFLAQHKYFEDEAFLQYLEYMEYWREPEYVKFIIYPTCLHMLTLLKNPQFRNDISRADLSKQVNDEIYYEWLGKGLQQYGSADDATLSQPQQEEDEKKVDVKKENE
Protein: Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like) (Q7Z5L2)
Organism: Homo sapiens (Human)
Interaction partners:
- Cystathionine beta-synthase
- Cystathionine beta-synthase-like protein
Sequence:
MQQESERCRVRARRPDMALYVPKARRGAVLLKTGDEEESCGSPNSVVKEKQKESSLSQKEVFKDKPEARRLNINPDRKEHNCREEKKSSTKLRMDTCLQKTNRVCSKRGTTESKEVLSQGQQQGAPNAGVITNAPLQRHFKPKKVECLEVETTDVTGHERILLSQACLEISEAQVPSKPFQNVEFCDFSRHEPDGEAFEDKDLEGRIETDTKVLEILYEFPRVFSSVMKPENMIVPIKLSSDSEIVQQSMQTSDGILNPSSGGITTTSVPGSPDGVFDQTCVDFEVESVGGIANSTGFILDQKDTDSIPATMGHISLSESTNDTVSPVMIRECEKNDSTADELHVKHEPPDTAVLAHETHRDSGFKNVGDITNKACMMDTTGMSCSDHVTVDSPYVVAVRIADETSINTRSFSKFVGMSADATPLHVARSGNDTEDFSNPSACSDIYGESISSHFTESTGKLIESLSDCASSLPIKKIAGSNYNTFLDSELSMLNGTKVLSDSAVGIDLGSTGDTTEALHELRTAEEFKTEEQDDSGSIEFGVSFPDRESSSMETSIEPKATETSHTEGITAIEESWESMFNDDGDCLDPRLLQEGILMHIKPENHCSKLSGNTKSRESIQEPRSDYYNHEVPDIDLSDCEFPHVIEIYDFPQEFHTEDLLRVFCSYQKKGFDIKWVDDTHALGVFSSPITARDALGIKHTMVKIRPLSQATRAAKAKARAYAEFLQPAKERPETSAALARRLVISALGVRSKQSKTEREAELKKLQEARERKRLEAKQREDIWEGRDQSTV
Protein: Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2) (P70172)
Organism: Mus musculus (Mouse)
Function: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Organic solute transporter subunit alpha
- Bile acid receptor
- Organic solute transporter subunit beta
- Cytochrome P450 7A1
- Bile salt export pump
- Fibroblast growth factor 15
- Gastrotropin
- Nuclear receptor subfamily 0 group B member 2
- 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
- G-protein coupled bile acid receptor 1
Sequence:
MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAMVMFSMGCNVEVHKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFVYTKMWVDSGTIVIPYDSIGISLVALVIPVSFGMFVNHKWPQKAKIILKIGSITGVILIVLIAVIGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVFAAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRPSFDETNKGFQPDEK
Protein: Lysosomal dipeptide transporter MFSD1 (Major facilitator superfamily domain-containing protein 1) (Q9DC37)
Organism: Mus musculus (Mouse)
Function: Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:31661432, ECO:0000269|PubMed:32959924, ECO:0000269|PubMed:38507452}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycosylated lysosomal membrane protein
- Solute carrier family 49 member A3
- Major facilitator superfamily domain-containing protein 8
Sequence:
MEDEDGEDRALLGGRREADSAVHGAPRALSALCDPSRLAHRLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIFGIRWGTVIFSCFVCIGQVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIEALLGSAGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAVVCLYLVNRAQGGNLNYSAKQRERMKLSHPE
Protein: Early transcribed membrane protein 10.1 (Q8IK21)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKISKILFFFVAIIAVKLFIPGYVLGGSSGSGGVKKLTDAQKKKKNIIIFSSVASVLAALIGAGVGFGIYYKNHKSDNKDEGNDKKGSNDSKNKSQEGSTPLLTAKA
Protein: SufE-like protein 2, chloroplastic (Protein SULFUR E 2) (Q9FXE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Participates in cysteine desulfurization mediated by NFS2. Can activate the cysteine desulfurase activity of NFS2 in vitro. Cysteine desulfurization mobilizes sulfur from L-cysteine to yield L-alanine and supplies the inorganic sulfur for iron-sulfur (Fe-S) cluster formation.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:17452319}.
Interaction partners:
- Cysteine desulfurase 1, chloroplastic
- Molybdenum cofactor sulfurase
- Cysteine desulfurase, mitochondrial
- Iron-sulfur cluster assembly protein 1
- Iron-sulfur cluster assembly protein 3
- Molybdenum cofactor sulfurase-like protein
- Emb|CAB16785.1
- Pyridoxal phosphate
- Pyridoxal phosphate
- Pyridoxal phosphate
Sequence:
MNTSSSFKALASPPLISTSRPTTKSFPNPRFTSRFSPKPITCMRDSLNLGSNPKAPSPFSLATVSVDAPLGTKTSDKLRILVSEFRSLTEPIDRVKRLLNYAATLAPLDESARISENRVTGCTTQVWLEIKMDEFGRMRFKADSDSEISKGFCSCLIWILDGAKPEEVMGVRSEDLSEMNVGVHGKEQSRVNTWHNVLMSMQKRTMTLVATDVAHQRGQRPPHQHDLLFKYVNGSYMESSKVHDYSISLLPLYYDFII
Protein: Transcription elongation factor SPT6 (Chromatin elongation factor SPT6) (Q3MNT0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription elongation factor SPT5
- Transcription factor IWS1
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase subunit
- FACT complex subunit SPT16
- Transcription elongation factor
- FACT complex subunit POB3
- RNA polymerase II subunit A C-terminal domain phosphatase
- RNA polymerase-associated protein CTR9
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MMKKKISAKKKNQQQQQLHQPTMSEVTEEERTRYEEEEDVRDSPSDSSEESEDDEEEIQKVREGFIVDDEEDEVQTKKRKSHKRKRDKERPHYDDALDDDDLELLLENSGLKRGSSSSGKFKRLKRKQIEDDEDEIESQDHQGEQQLRDIFSDDEEVEEEAAPRIMDEFDGFIEEDDFSDEDEQTRLERREQRKKKKQGPRIDTSNLSNVDRQSLSELFEVFGDGNEYDWALEAQELEDAGAIDKEEPASLDEVFEHSELKERMLTEEDNLIRIIDVPERYQMYRSALTYIDLDDEELELEKTWVANTLLKEKKAFLRDDWVEPFKQCVGQVVQFVSKENLEVPFIWNHRRDYLEYVDPDAPIPGSVRELMISEDDVWRIVKLDIEYHSLYEKRLNTEKIIDSLEIDDELVKDIKTLDSMVAIQDMHDYIQFTYSKEIRQREETQNRKHSKFALYERIRENVLYDAVKAYGITAKEFGENVQDQSSKGFEVPYRIHATDDPWESPDDMIERLIQDDEVIFRDEKTARDAVRRTFADEIFYNPKIRHEVRSTYKLYASISVAVTEKGRASIDAHSPFADIKYAINRSPADLIAKPDVLLRMLEAERLGLVVIKVETKDFANWFDCLFNCLKSDGFSDISEKWNQERQAVLRTAISRLCAVVALNTKEDLRRECERLIASKVRHGLLAKIEQAPFTPYGFDIGSKANVLALTFGKGDYDSAVVGVYIKHDGKVSRFFKSTENPSRNRETEDAFKGQLKQFFDEDETPDVVVVSGYNANTKRLHDVVYNFVSEYGISVKSEFDDGSSQLVKVIWGQDETARLYQNSERAKKEFPDKPTLVKYAISLGRYLQDPLLEYITLGDDILSLTFHEHQKLISNDLVKEVVESAFVDLVNAVGVDINESVRDSRLAQTLKYVGGLGPRKASGMLRNIAQKLGSVLTTRSQLIEYELTTRTIFINCSAALKISLNKSINVKDFEIEILDTTRIHPEDYQLAMKMAADALDMDEESELHEKGGVIKELLENDPSKLNLLNLNDFANQIYKLTHKLKFRSLQAIRLELIQGFAEIRSPFRILTNEDAFFILTGEKPQMLKNTVIPATITKVTKNHHDPYARIRGLKVVTPSLIQGTIDENAIPRDAEYVQGQVVQAVVLELYTDTFAAVLSLRREDISRAMKGGVVREYGKWDYKAEDEDIKREKAKENAKLAKTRNIQHPFYRNFNYKQAEEYLAPQNVGDYVIRPSSKGASYLTITWKVGNNLFQHLLVEERSRGRFKEYIVDGKTYEDLDQLAFQHIQVIAKNVTDMVRHPKFREGTLSVVHEWLESYTRANPKSSAYVFCYDHKSPGNFLLLFKVNVSAKVVTWHVKTEVGGYELRSSVYPNMLSLCNGFKQAVKMSSQQTKSYNTGYY
Protein: Early transcribed membrane protein 10.2 (Q8IJ76)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVGKIFFLLNILVVCHFIISCLCRNGQTTRGNLLALKAIEQDLQQKKNRKRNLILYSLGSAALIAALVVTGIGLNMYMKKKNVDSEVQEIIDEKDEKVKEKPAEKKKTTVKIVSKRVPVKSKSSNGKSKARTVNSEVSPKLDDEKKEDLLKFNDNDLLLAAESLKELNPKYDENTQGNDSFKNINEPRKLASFSLYDALADASEQNKNKDAESSTGQIPTPTESSHGISDGKKDTSTNDMDPLNPYGSSKRNSSEDKPTSESKGTTPESNFDSKTPEIKEINEPIIVPSYYPTTGPNPNTHGPPSRRISTSRSSGSSNRSSSGTSTRSKGPSSPLRDSSGRSSGRSTTPRVRKE
Protein: Diacylglycerol kinase (DAGK) (EC 2.7.1.107) (Diglyceride kinase) (DGK) (P0ABN1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis. In vitro, phosphorylates various substrates, including sn-1,2-dioleoylglycerol, sn-1,2-dioctanoylglycerol, sn-1,2-dipalmitoylglycerol, sn-1,2-dipalmitate and ceramide. Catalyzes direct phosphoryl transfer from Mg-ATP to diacylglycerol and does not form an enzyme-phosphate intermediate.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:217867, ECO:0000269|PubMed:2984194, ECO:0000269|PubMed:8071224}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:8071224}.
Interaction partners:
- Phosphatidate cytidylyltransferase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Uncharacterized protein YnbB
- CDP-diacylglycerol pyrophosphatase
- Glycerol-3-phosphate acyltransferase
- Glycerol-3-phosphate dehydrogenase [NAD
- LexA repressor
- Anaerobic glycerol-3-phosphate dehydrogenase subunit A
- Endoribonuclease YbeY
- Aerobic glycerol-3-phosphate dehydrogenase
Sequence:
MANNTTGFTRIIKAAGYSWKGLRAAWINEAAFRQEGVAVLLAVVIACWLDVDAITRVLLISSVMLVMIVEILNSAIEAVVDRIGSEYHELSGRAKDMGSAAVLIAIIVAVITWCILLWSHFG
Protein: Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (ELAM-1 ligand fucosyltransferase) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase) (P22083)
Organism: Homo sapiens (Human)
Function: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- E-selectin
- Type 2 lactosamine alpha-2,3-sialyltransferase
- Beta-1,4-galactosyltransferase 1
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
- Beta-1,4-galactosyltransferase 4
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
- Beta-1,4-galactosyltransferase 2
Sequence:
MRRLWGAARKPSGAGWEKEWAEAPQEAPGAWSGRLGPGRSGRKGRAVPGWASWPAHLALAARPARHLGGAGQGPRPLHSGTAPFHSRASGERQRRLEPQLQHESRCRSSTPADAWRAEAALPVRAMGAPWGSPTAAAGGRRGWRRGRGLPWTVCVLAAAGLTCTALITYACWGQLPPLPWASPTPSRPVGVLLWWEPFGGRDSAPRPPPDCRLRFNISGCRLLTDRASYGEAQAVLFHHRDLVKGPPDWPPPWGIQAHTAEEVDLRVLDYEEAAAAAEALATSSPRPPGQRWVWMNFESPSHSPGLRSLASNLFNWTLSYRADSDVFVPYGYLYPRSHPGDPPSGLAPPLSRKQGLVAWVVSHWDERQARVRYYHQLSQHVTVDVFGRGGPGQPVPEIGLLHTVARYKFYLAFENSQHLDYITEKLWRNALLAGAVPVVLGPDRANYERFVPRGAFIHVDDFPSASSLASYLLFLDRNPAVYRRYFHWRRSYAVHITSFWDEPWCRVCQAVQRAGDRPKSIRNLASWFER
Protein: Striatin-interacting protein 1 homolog isoform X2 (Striatin-interacting protein 2) (X1WE96)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Striatin
- Striatin, calmodulin-binding protein 3.
- Striatin, calmodulin-binding protein 4.
- Cortactin-binding protein 2
- CTTNBP2 N-terminal-like b.
- MOB-like protein phocein
- Suppressor of IKBKE 1
- Serine/threonine-protein kinase 25
- Sarcolemmal membrane-associated protein
- non-specific serine/threonine protein kinase
Sequence:
MQQTDDMEVPLIHDSNSNTHTCLPQERDGFHQQKDSEGSMESPNLEFEYGDTDSFTAELSELYSYTEEPEFSLNRDYFEEDFKNHVKGRRWMELSVEEQRAYVMRLLDALEVTDRDKRLKVARAILYLAQGVFDECDTETDVLYWSRHNVFLLYDMGIFTALLELLSMEIDNNQACSSAVRKPAISLADSTELRVLLSIMYLMVETIRVEMESDSPERKAAREAFKMELGSPLYNGEPFALLLFTMVTKFCSMNAPHFPMKKVLLLLWKTILFTLGGFEELQEMKVRMRDHLNLPPLPEDSIKVVRNMRAASPPASAMELIEQQQQQKRGRRSRRPLVKQDSLDTYNERDPFKNDDARDEEDDPEDVDSGIEGEVDPLDRDVIIQPPPPPPPLRPPTERMSFPKGLPWAPKVREKDIEHFLETSRNKFIGFTLGNDIDTLVGLPRPIHESVKTLKLHKYVSIAEVQIKREDELQQCPMTMGEEEVEETPTEILYLGMLPSLSQYVIALLKLLLAAAPTSKAKTDSINILADVLPEEMPITVLQSMKLGIDVNRHKEIIVKAISALLLLLLKHFKLNHIYQFEYVAQHLVFANCIPLILKFFNQNIMSYISAKNSICALDFPHCAVHEMPELTAESLEAGDSNQFCWRNLFSCINLLRILNKITKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKIQTKYLGRQWRKSNMKTMSAIYQKVRHRLNDDWAYGNDIDARPWDFQAEECALRESIEKFNTRRYDKNQNSEFAPVDNCLQSVLGQRVDLPEDFHYSYEMWLEREVFSQPIQWEGLLQAQ
Protein: Gamma-crystallin D (Gamma-D-crystallin) (Gamma-crystallin 2-2) (P10067)
Organism: Rattus norvegicus (Rat)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Gamma-crystallin C
- Alpha-crystallin A chain
- Alpha-crystallin B chain
- Gamma-crystallin A.
- Phakinin
- Gap junction alpha-8 protein
- Filensin
- Gap junction alpha-3 protein
- Lens fiber membrane intrinsic protein
- Heat shock transcription factor 4
Sequence:
MGKITFYEDRGFQGRHYECSTDHSNLQPYFSRCNSVRVDSGCWMLYEQPNFTGCQYFLRRGDYPDYQQWMGFSDSVRSCRLIPHAGSHRIRLYEREDYRGQMVEFTEDCPSLQDRFHFNEIYSLNVLEGCWVLYEMTNYRGRQYLLRPGEYRRYHDWGAMNARVGSLRRVMDFY
Protein: Chromosome segregation protein sudA (Q5B0N1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
Interaction partners:
- Condensin complex subunit 1
- Nuclear condensin complex subunit Smc4, putative
- Hypothetical nuclear condensin complex subunit 3
- Condensin complex subunit 2
- Alpha-L-rhamnosidase C, putative
- Kinesin-like protein bimC
- Sister chromatid cohesion acetyltransferase Eco1, putative
- DNA polymerase eta
- DNA topoisomerase 2
- Probable kinetochore protein ndc80
Sequence:
MRITEIIIDGFKSYAVRTVISGWDESFNSITGLNGSGKSNILDAICFVLGITNMSTVRAQNLQDLIYKRGQAGVTKASVTIVFDNRDTAKSPIGFEEYATISVTRQIVLGGTSKYLINGHRAQQQTVQNLFQSVQLNINNPNFLIMQGRITKVLNMKAVEILSMIEEAAGTRMFEDRREKAAKTMAKKDLKLQEIEGLLKEEIEPKLEKLRAEKRAFLDFQQTQNDLERLTRLVVAHDYLRSGDRLRASGEECEKKKRKIQALEDNTAKLKSEIAHMEEDVKRVKAVRDKELRKGGKFQALEDEVKAHSHELVRLTTVFDLKKASIAEEKEKSKELQKSVKDLETSLKEKKKIYDKLQAEYDAAKAELDAQTAEVEQKEELLQTLQTGVASKEGQESGYQGQLQDARNRASNAATEQEQAKLKIAHLEKRIKEEEPRAKKAKEQNSGLLKELEGLKSQAKKLEYELSKLGFEPGREEQLYQEQSGLQKEIRELRQRADGLQRKVANIEFNYSDPYPNFDRSKVKGLVAQLFTVDKEKLQAATALEICAGGRLYNVVVDSSDTGTQLLQKGKLRKRVTIIPLNKISAFRASVEKIGAAQNLAPGKVDLALSLIGYDEEITAAMNYVFGNTLIANDAETAKRVTFDPSVRIKSVTLDGDVYDPSGTLSGGSAPNSSGVLVTLQKLNEITREIRSKERVLAALEETMKKEKKKLDAVRSIKQELDLKNHEIKLTEEQIGGNSSSSIIQAVEEMKANIEQLKQNISDAKLRQSEASKDIKRIEKDMREFNNNKDSKLEELQTTLNALKKSLSKNLTSVKNLHKELQASRLESEQVGSDLSAAEEQYAESESTLKAQLEEVDSLKREQARIKDAHDIAQAHLDDERAKLTGFDDELRDLEQTMQSKNSQITEEGLEMQKLGHQLEKLQKEQNAAEQAVAHLEAEHEWIADEKDNFGRPNTVYDFKNQNIAECKATLRNVTERFQGMKKKINPKVMNMIDSVEKKEAALKNMMRTVIRDKSKIEETIINLNEYKKEALHKTWTKVNADFGQIFSELLPGSFAKLDPPEGKDITDGLEVKVSLGKVWKQSLTELSGGQRSLIALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRTRFSEGTSVVQALTPADLR
Protein: Amino acid permease 2 (Amino acid transporter AAP2) (Q38967)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Amino acid-proton symporter. Stereospecific transporter with a broad specificity for histidine, arginine, glutamate and neutral amino acids, favoring small amino acids such as alanine, asparagine and glutamine. Accepts also large aromatic residues such as in phenlalanine or tyrosine. Has a much higher affinity for basic amino acids as compared with AAP1. May function in xylem-to-phloem transfer and in uptake of amino acids assimilated in the green silique tissue.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- WAT1-related protein At1g01070
- WAT1-related protein At2g40900
- WAT1-related protein At1g44800
- WAT1-related protein At4g01430
- Probable polyamine transporter At3g13620
- Cationic amino acid transporter 6
- WAT1-related protein At2g39510
- Probable polyamine transporter At3g19553
- WAT1-related protein At1g25270
Sequence:
MGETAAANNHRHHHHHGHQVFDVASHDFVPPQPAFKCFDDDGRLKRTGTVWTASAHIITAVIGSGVLSLAWAIAQLGWIAGPAVMLLFSLVTLYSSTLLSDCYRTGDAVSGKRNYTYMDAVRSILGGFKFKICGLIQYLNLFGIAIGYTIAASISMMAIKRSNCFHKSGGKDPCHMSSNPYMIVFGVAEILLSQVPDFDQIWWISIVAAVMSFTYSAIGLALGIVQVAANGVFKGSLTGISIGTVTQTQKIWRTFQALGDIAFAYSYSVVLIEIQDTVRSPPAESKTMKKATKISIAVTTIFYMLCGSMGYAAFGDAAPGNLLTGFGFYNPFWLLDIANAAIVVHLVGAYQVFAQPIFAFIEKSVAERYPDNDFLSKEFEIRIPGFKSPYKVNVFRMVYRSGFVVTTTVISMLMPFFNDVVGILGALGFWPLTVYFPVEMYIKQRKVEKWSTRWVCLQMLSVACLVISVVAGVGSIAGVMLDLKVYKPFKSTY