wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) (O95863)
Organism: Homo sapiens (Human)
Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Subcellular location: Nucleus {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:24157836, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25893292}. Cytoplasm {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15833848}. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. {ECO:0000269|PubMed:15448698}.
Interaction partners:
- Histone deacetylase 1
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- Histone deacetylase 2
- Histone-lysine N-methyltransferase EZH2
- DNA
- Mothers against decapentaplegic homolog 3
- Cellular tumor antigen p53
- Histone-lysine N-methyltransferase EHMT2
- REST corepressor 1
- Glycogen synthase kinase-3 beta
Sequence:
MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGCPR
Protein: Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) (P31350)
Organism: Homo sapiens (Human)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22632967}. Nucleus {ECO:0000269|PubMed:22632967}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000269|PubMed:22632967}.
Interaction partners:
- Ribonucleoside-diphosphate reductase large subunit
- Ribonucleoside-diphosphate reductase subunit M2 B
- Cyclin-dependent kinase 1
- DNA topoisomerase 2-alpha
- Thymidylate kinase
- Nucleolar and spindle-associated protein 1
- Disks large-associated protein 5
- Kinesin-like protein KIF11
- Proliferation marker protein Ki-67
- Centrosomal protein of 55 kDa
Sequence:
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
Protein: Probable inorganic phosphate transporter 1-2 (AtPht1;2) (H(+)/Pi cotransporter) (Q96243)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity transporter for external inorganic phosphate.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Inorganic phosphate transporter 2-1, chloroplastic
- Phosphate transporter PHO1
- SEC12-like protein 1
- Probable ubiquitin-conjugating enzyme E2 24
- Mitochondrial phosphate carrier protein 1, mitochondrial
- Protein PHOSPHATE STARVATION RESPONSE 1
- Probable anion transporter 4, chloroplastic
- Probable anion transporter 5
- Probable transcription factor At4g00610
Sequence:
MAEQQLGVLKALDVAKTQLYHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKNIKQATADMSKVLQTDIELEERVEDDVKDPRQNYGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPENRIGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNQDKAKVDAGYPPGIGVKNSLIVLGVLNFIGMLFTFLVPEPKGKSLEELSGEAEVSHDEK
Protein: GIT ArfGAP 1 (J3QL89)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
ELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKVQGPKRGPGVGGPRAGAGVENPI
Protein: Cyclin-dependent kinases regulatory subunit (Q24152)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to the catalytic subunit of the cyclin dependent kinases Cdk1 and Cdk2, and is essential for their biological function.
Interaction partners:
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-A
- S-phase kinase-associated protein 2
- Cyclin-dependent kinase 2
- G2/mitotic-specific cyclin-B
- G2/mitotic-specific cyclin-B3
- cyclin-dependent kinase
- Cell division cycle protein 20 homolog
- Serine/threonine-protein kinase polo
- Mitotic spindle assembly checkpoint protein MAD2A
Sequence:
MSKDIYYSDKYYDEQFEYRHVVLPKELVKMVPKTHLMTEAEWRSIGVQQSRGWIHYMIHKPEPHILLFRRPKTD
Protein: Friend of echinoid, isoform G (Q9VQW1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSTIKLLIIGQLWLSIGLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFENVAIGDVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQIRWIKDGTEILPTRKMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKVYALNSKGTSGYSNEILATTKVSKIPPPLHVSYDPNSHVLGINVAATCLSLIAVVESLVTRDATVPMWEIVETLTLLPSGSETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTMALAETAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSALVAIIIASLSFVVFLGLLYAFCHCRRKHAAKKESSSVGGGVGGGNANATANPGSTGAKEYDLDLDASRRPSLSQDPQQSQQQPPPPPPYYPTGTLDSKDIGNGNGGMELTLTALHDPDEQLNMQQQQHHSNHGQYQQPKAILGIYGGVAGSGGNNSGGQHPHSNGYGYHVTSAIGVDSDSYQVLPSVANSAAGSHGHGSGHGHGLGAGE
Protein: Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Q793F9)
Organism: Rattus norvegicus (Rat)
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization and chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (By similarity). In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Critical for normal erythroblast cytokinesis and correct erythropoiesis (By similarity).
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q8VEJ9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VEJ9}. Midbody {ECO:0000250|UniProtKB:Q9UN37}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UN37}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody. Localized in two distinct rings on either side of the Flemming body. {ECO:0000250|UniProtKB:Q9UN37}.
Interaction partners:
- Vesicle trafficking 1
- Charged multivesicular body protein 1A
- Charged multivesicular body protein 1B2
- Charged multivesicular body protein 5
- Charged multivesicular body protein 6
- vesicle-fusing ATPase
- Similar to RIKEN cDNA 1500016L11
- IST1 homolog
- Charged multivesicular body protein 2B
- Charged multivesicular body protein 3
Sequence:
MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAEKLKDYLRNKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES
Protein: Sperm-associated antigen 16 protein (Pf20 protein homolog) (Q8K450)
Organism: Mus musculus (Mouse)
Function: Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12391165}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:12391165}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:12391165}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:12391165, ECO:0000269|PubMed:27682589}. Note=Detected on the sperm flagellum. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules. {ECO:0000269|PubMed:12391165, ECO:0000269|PubMed:27682589}.
Interaction partners:
- Transcription initiation factor TFIID subunit 11
- Meiosis-expressed gene 1 protein
- Sperm-associated antigen 6
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 13
- Transformation/transcription domain-associated protein
- Transcriptional adapter 3
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 12
Sequence:
MAAPSGVPPLRVLEELGIGLSPTGEVTEAVTSEGAYYLEQVTITETSEDECEYEEIPDDNFSIPEGEEDLEKAIHIIGEQARDIHILEQQTILPARNVMQEAIEDFLCNFLIKMGMTRTLDCFQAEWYELIQKKGSDFKGLGNVPDVYSQVMLLETENKNLKKELKHFKQAAEKAKEDLLRTQKERDFHRMHHKRIVQEKNKLIADLKGLKLHYASYEPTIRVLHEKHHALLKEKMLTSLERDRAVGKISGLQATLKNIDMGHIQVPVIKGSYESASITRESGDRAGHSCEKENSSEGPTQKSLREAREEVGYKSKLKNEKKDSEFPVDMQPDPNVTSCTENVSAAKFDYKLNNIFRLHELPVSCIVMHPCRDYLISCSEDRLWKMVGLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASANGIIHLLDLKSGQIHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLWI
Protein: Protein Tat (Transactivating regulatory protein) (P04613)
Organism: Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1)
Function: Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs.
Subcellular location: Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04079}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04079}. Secreted {ECO:0000255|HAMAP-Rule:MF_04079}. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type. {ECO:0000255|HAMAP-Rule:MF_04079}.
Interaction partners:
Sequence:
MDPVDPNLEPWNHPGSQPRTPCNKCYCKKCCYHCQMCFITKGLGISYGRKKRRQRRRPPQGNQAHQDPLPEQPSSQHRGDHPTGPKE
Protein: Dynamin associated protein 160, isoform C (IP14822p) (Q1WWC9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQTSFEDKRKENYVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQTTLNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSGKPAKANGTTKK
Protein: Olfactory receptor (A4IF55)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
GESNKTTPVSSFILLGLSAHPKLEKTFFVLILLMYLVILLGNVVLILVSILDSHLHTPMYFFLGNLSFLDICYTTSSVPLILDSFLTPRKTISFSGCAVQMFLSFAMGATECVLLGMMAFDRYVAICNPLRYPVVMSKAAYVPMAAGSWVSGSITATVQISLAMTLPFCGDNVINHFTCEILAVLKLACADISINVISMAVANAMFLGVPVLFIFVSYIFILSTILRIPSAEGRKKAFSTCSAHLTVVLVFYGTILFMYGKPKSKDPLGADKQDLADKLISLFYGVVTPMLNPIIYSLRNKDVKAAVTNLVGQKHFKW
Protein: Uncharacterized protein YGL082W (P53155)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Polyubiquitin
Sequence:
MDVTFLTKNVQINGTQFKILLQNGQGECALIALANVLLISPAHARYAQEISRLVRGKETVTLNELVQTLADMGVQNPNGTDVDKQQLLQILPQLYSGLNINPEFNGSFEDGVEMSIFRLYNVGIVHGWIIDGDNDPNSYEHVSKYSYMGAQKVLVQSYEIQKNNAQFENSEQIQSDAPYLKSFLARSATQLTEYGLTHLREILVERSYAVLFRNDHFCTLYKNNGELFTLVTDPTYRNRKDINWQSLKSVNGSQDSYYTGNFIPTSLERTETTATGQNESYISNPFSDQNTGHVTSNQVNSGASGVQQIEDDEELARRLQEQEDMRAANNMQNGYANNGRNHQRERFERPEKNSKKNKFLPFNGSNKEKKRDKLKKNCVIM
Protein: Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase] (Q05754)
Organism: Rattus norvegicus (Rat)
Function: Conversion of dopamine to noradrenaline.
Subcellular location: [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:P09172}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000250|UniProtKB:P09172}. Secreted {ECO:0000250|UniProtKB:P09172}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P09172}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P09172}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000305|PubMed:11418593}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P09172}.
Interaction partners:
- Phenylethanolamine N-methyltransferase
- Aromatic-L-amino-acid decarboxylase
- Amine oxidase [flavin-containing] A
- Catechol O-methyltransferase
- Amine oxidase [flavin-containing] B
- Transmembrane O-methyltransferase homolog
- Tyrosine 3-monooxygenase
- Amine oxidase [copper-containing] 3
- Phenylalanine-4-hydroxylase
- Pro-neuropeptide Y
Sequence:
MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYHIPLDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNESEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSAVEEPDPRCPIRQTRGPAGPFVVITHGGRH
Protein: LIM and senescent cell antigen-like-containing domain protein (A0A8I5ZPU7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|PIRNR:PIRNR038003}. Cell membrane {ECO:0000256|PIRNR:PIRNR038003}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR038003}.
Interaction partners:
Sequence:
MLGVAAGMTNSNMANALASATCERCKGGFDPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVSCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLSETLGRK
Protein: Double-stranded RNA-binding protein Staufen homolog (Q3L1C9)
Organism: Aplysia californica (California sea hare)
Function: RNA-binding protein which is required for syntaxin location in sensory neurons during long-term synaptic facilitation. Binds to syntaxin mRNA and is required to maintain its accumulation at the axon hillock following neuronal stimulation and at the opposite pole in stable unstimulated sensory neurons.
Subcellular location: Perikaryon {ECO:0000269|PubMed:16687512}. Cell projection {ECO:0000269|PubMed:16687512}. Note=Present in both the perikaryon and neurites of sensory neurons. In unstimulated sensory neurons, located in the region of the perikaryon opposite the axon hillock. After neuronal stimulation, expressed at highest levels at the axon hillock. {ECO:0000269|PubMed:16687512}.
Interaction partners:
Sequence:
MSHNHMMNNQQQHAAMINPGAVASVSGAQVQQRSMMSQQRGGSHAINSSKSPYQLQTSSISQFSHLQQQQQQQQQQQLVNNYHKQKQMSPDITSHQFSSSTGGGMPTQNGNYQSMSGSSIHTSMGLDNGQLSLQHQHHQYSSQPAQALQTSVQQHHYQSQQMTQQQQQAAQQQPQQQYQSFQQQHHLIQQQQQQQQIHTQQQQQLPQQAMHQQQQHLQLHQHLQQRSLNQQQQQQQRYQKQQQQPQPKQILQHSPTSGKSLSSAPHGTSVQPSTLLNHHQHNMAAPQVTPVTNGESAGEDTSPKDSPQAPKTSGRDSVHVSDNEESASNASEMQQSLANTKEKTPMCLINELARFNKMSHQYTLVDEQGPAHKKTFYVKLKLGDEEYSASGESIKKAQHAAAAIALVETKCPHPPPKPARLGCCDLEKSADGNITPTVELNALAMKRGEPALYKSIEPQQPPYYHQPNMDFRGLYNQRYHQYMRASRDPRYRGNGVLWPLRYHYPRMNRAFYVSLRVGHREFIGDGPTRQAARHNAAQKALRILKNLPVQSGEKKSEEQADEAAEDACEEDVDDSLKSEISLVHEIALRRNMVVQFEVIRETGPPHMKNFLTRCTVADMVTEGEGNSKKTSKKKAAELMLEELRKLPPLATPAFPRPKSKIQMNKKKNRNLIKSELQQQKADPNYGVGINPISRLIQIMQAQKKKEPVYTLVTERGLPRRREFIVQVEVEDKTCPGSGPNKKLAKRAAAEAMLQLLGYTKPSPQPTKSSFKNPSTGEAGQTNGDKKVTFVGGDSPGDGDDKVSSGSNQQRVPGLLHLPSKSSASSSGNQHTASKESLVNLASILKPNLRPEIQLRELCKAMDCQLEIDDFTKKRTSGTEHITRITIGSENPQSFHGSNTSLESSRDMAALDALKVLVARAKDIHPGGDGPQVKKDVLARSGSGMKKDFSK
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9W0D7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004585}.
Interaction partners:
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal 1 receptor
- Peroxin-19
- Peroxisome biogenesis factor 2
- Peroxin-7
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX16
- Peroxin 11
- Peroxisomal membrane protein PEX14
Sequence:
MDFRNARARQPEIVRSVQKDARYTNELAEDLSDVLRLTGPRNWIKYNQMCRLLAELSYHGFASANNLQTLGEEYTGIIQVDGNYKQIPSRLLQLIAIVLEFGGDSLFQRLMQKLDTYVANNDEIRTEIKPQLKKIIQRLRQSPSYVKALHKSLFYLDASKYQLSKRTTGINYVLIRHWLQPEFSLYGYKILGVITFLQVSVSLAISGWDAWREHKRQQLESIKQAGKNFLQRSSSTKDVDPNTPQCILCLEPRSDSSLTPCGHIFCWSCLLEWLEERDECPLCRESLKKSQVILLQNYA