wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (Q9FJD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16582012}. Endosome membrane {ECO:0000269|PubMed:16582012}; Peripheral membrane protein {ECO:0000269|PubMed:16582012}; Cytoplasmic side {ECO:0000269|PubMed:16582012}. Prevacuolar compartment membrane {ECO:0000269|PubMed:16582012}; Peripheral membrane protein {ECO:0000269|PubMed:16582012}; Cytoplasmic side {ECO:0000269|PubMed:16582012}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 35C
- Vacuolar protein sorting-associated protein 35A
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 35B
- Sorting nexin 2A
- Sorting nexin 1
- Sorting nexin 2B
- Uncharacterized protein AT4g35940
- DNA ligase
- DNA ligase-like protein
Sequence:
MNYLLGAFKPACNISITFTDGKNRKQVPTKKDNGQIVMNPLFQSQETIAGKINIEPYQGKKVEHNGVKVELLGQIEMYFDRGNFYDFTSLVREIDVPGEIYERKTYPFEFSSVEMPYETYNGVNVRLRYVLKVTVTRGYAGSIVEYQDFVVRNYVPLPPINNSIKMEVGIEDCLHIEFEYNKSKYHLKDVILGKIYFLLVRIKIKNMDLEIRRRESTGAGANTHVETETLAKFELMDGAPVRGESIPVRVFLTPYDLTPTHKNINNKFSVKYYLNLVLVDEEDRRYFKQQEITLYRLKEETS
Protein: Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) (P55735)
Organism: Homo sapiens (Human)
Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:8972206}; Peripheral membrane protein {ECO:0000269|PubMed:8972206}; Cytoplasmic side {ECO:0000269|PubMed:8972206}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8972206}; Peripheral membrane protein {ECO:0000269|PubMed:8972206}; Cytoplasmic side {ECO:0000269|PubMed:8972206}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:14517296, ECO:0000269|PubMed:18160040}. Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=In interphase, localizes at both sides of the NPC. {ECO:0000269|PubMed:14517296}.
Interaction partners:
- Protein transport protein Sec24C
- Nucleoporin SEH1
- Protein transport protein Sec24D
- Protein transport protein Sec31A
- Protein transport protein Sec23B
- GATOR2 complex protein MIOS
- Nuclear pore complex protein Nup98-Nup96
- GATOR2 complex protein WDR59
- Nuclear pore complex protein Nup133
- Nucleoporin Nup43
Sequence:
MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTEGQQNEQ
Protein: Septum site-determining protein MinC (P18196)
Organism: Escherichia coli (strain K12)
Function: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
Interaction partners:
- Septum site-determining protein MinD
- Cell division protein FtsZ
- Division inhibition protein DicB
- Cell division topological specificity factor
- Cell shape-determining protein MreC
- Cell division protein FtsA
- Rod shape-determining protein MreD
- Cell division protein ZapA
- Cell division protein ZipA
- Nucleoid occlusion factor SlmA
Sequence:
MSNTPIELKGSSFTLSVVHLHEAEPKVIHQALEDKIAQAPAFLKHAPVVLNVSALEDPVNWSAMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPILTEGKEKAPRPAPTPQAPAQNTTPVTKTRLIDTPVRSGQRIYAPQCDLIVTSHVSAGAELIADGNIHVYGMMRGRALAGASGDRETQIFCTNLMAELVSIAGEYWLSDQIPAEFYGKAARLQLVENALTVQPLN
Protein: tRNA N(3)-methylcytidine methyltransferase trm140 (EC 2.1.1.-) (Q9P7L6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr). Does not catalyze N(3)-methylcytidine modification of tRNA(Ser).
Interaction partners:
- Serine--tRNA ligase, mitochondrial
- Serine--tRNA ligase, cytoplasmic
- 25S rRNA
- tRNA
- tRNA
- tRNA dimethylallyltransferase
- tRNA
- tRNA
- Putative tRNA pseudouridine synthase C16C4.06c
- tRNA
Sequence:
MDTTPDNSEKKKTSSVREATFSINESFGGRLLTEEEDVFEQNAWDHVEWDDEHLALAKKCIEEQKLYPVTEKDAYMTHPERYWDQFYGKNEGKFFMNRRWIAQEFPELLDLLKEDAGEKSILEIGCGAGNTIWPILKENKNSNLKIFAVDYSEKAIDVVKQNPLYDAKFCSASVWDLAGSDLLRSIEEASIDAITLIFCFSALSPDQWQQAIENLYRLLKPGGLILFRDYGRLDLTQLRAKKNRILSENFYIRGDGTRVYYMTNEELVDVFGKNFKIIQNGVDKRLIVNRKKRVKMYRCWLQAKFQK
Protein: Zinc transporter zipt-7.1 (Histidine-rich membrane protein KE4 homolog 1) (Q9XUC4)
Organism: Caenorhabditis elegans
Function: Zinc transporter which regulates intracellular zinc levels. Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function. Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm. The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization.
Subcellular location: Membrane {ECO:0000269|PubMed:29879108}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes to membranous organelles. {ECO:0000269|PubMed:29879108}.
Interaction partners:
- Zrt
- Zinc transporter ZIP3
- Zinc transporter ZIP3
- Proton-coupled zinc antiporter SLC30A5
- G-protein coupled receptors family 1 profile domain-containing protein
- BZIP domain-containing protein
- Spermatocyte protein spe-8
- Transporter
- Serine/threonine-protein kinase spe-6
Sequence:
MRLQLVALLFALVFNAFSHEHSHEHHHEGDGSEILTKVGWNDHSEELHDHHEHDHDHHDEQLIRKNHTSHREIQHSRLSTLKVWVFSLSAVVGISLAPCTLLFFIPAQHANGPFLKILLAFGAGGLLGDALLHIIPHSLSPHDHSHDHHDHNHSHKEHDHSHDHSNQLRVGTFVIAGILVFMMVEQLVRIIKGGHCHSHENGHIVADEHRHLNEHDHEHSEEKKQQVEGLKDVKASAYLNLVADFVHNVTDGLAIGASFSAGNTLGWITTLTVLLHELPHEVGDFAILVQSGFSKYQAIRLQAVTALGAITGCVFSLLVSNPGSLNNDADTSAIMPFTAGGFIYIATVSVVPELLESGDHNNLSKVAKMAQSLVHVLAICMGVGMMYIVSLVE
Protein: Pescadillo (P79741)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
Interaction partners:
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein wdr12
- Ribosome biogenesis protein bop1
- Ribosome biogenesis protein NSA2 homolog
- NOC2-like nucleolar-associated transcriptional repressor
- EBNA1-binding protein 2.
- Ribosome assembly factor mrt4
- RNA helicase.
- Guanine nucleotide-binding protein-like 3
- WD repeat domain 74.
Sequence:
MGGLQKKKYESGSATNYITRNKARKKLSLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTYYLLKDIRFLLHEPIVGKFREYKIFVRKLRKAYGKAEWSAVERLKENKPGYKLDHIIKERYPTFIDALRDVDDALSMCFLFSTFARTGKCHVQTIQLCRRLSVEWMNYIISSRSLRKVFLSIKGIYYQAEVLGQTITWIVPYQFAHNHPTDVDYRVMATFTELYTTLLGFVNFRLYQTLNLVYPPKLDGQGEISLKAEFEEDYALESESYTEKLSALSASLARMVASVEEEEAELDHFPTEGEDQEKMEVREKMEQQQSKQKKLFEGLKFFLNREVPRESLAFVIRCFGGEVSWDKSLCIGSTYEATDETITHHIVDRPSMDKQYINRYYIQPQWVYDSVNAKIQLPVEEYFLGVTLPPHLSPFVEETEGDYVPPEKLKLMALQRGEKPQAEEDEEEEGEEEEDDEEDEEDDEQSEDEEEAEEEANLAEMEEKRSQGKSLSVKVTPGKAKAENRARAAEEEKAEEKRLAIMMMKKKEKYLYDKIMFGKKRKVREANKLAAKRKAHDDASKADKKKKKKKC
Protein: Terminal nucleotidyltransferase 5B (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46B) (Q96A09)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner. May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs. Prefers RNA molecules that are adenosine-rich close to 3'-end. In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32009146}. Nucleus {ECO:0000269|PubMed:32009146}.
Interaction partners:
Sequence:
MMPSESGAERRDRAAAQVGTAAATAVATAAPAGGGPDPEALSAFPGRHLSGLSWPQVKRLDALLSEPIPIHGRGNFPTLSVQPRQIVQVVRSTLEEQGLHVHSVRLHGSAASHVLHPESGLGYKDLDLVFRVDLRSEASFQLTKAVVLACLLDFLPAGVSRAKITPLTLKEAYVQKLVKVCTDSDRWSLISLSNKSGKNVELKFVDSVRRQFEFSIDSFQIILDSLLLFGQCSSTPMSEAFHPTVTGESLYGDFTEALEHLRHRVIATRSPEEIRGGGLLKYCHLLVRGFRPRPSTDVRALQRYMCSRFFIDFPDLVEQRRTLERYLEAHFGGADAARRYACLVTLHRVVNESTVCLMNHERRQTLDLIAALALQALAEQGPAATAALAWRPPGTDGVVPATVNYYVTPVQPLLAHAYPTWLPCN
Protein: Leukocyte immune-type receptor TS32.17 L2.3a (Q0GKA4)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
ILLISLIRVGQAQAVFKPVLSVEPNSPQIFRGDMVTLTCRISGGNGPYHWNKDGGYSHSSAENYYTIKVDQSHKYRCYGSIDVRSTPWSNEVTLSVIERPRAVLTLQPDGQIFSGQEVTFTCEIRGHADTEWMYNWNKDGVQISSYTESRKYSFTAVESLSAKYTSSGRRRSDSQTSETSNTVTLTVSVLSDGKAPLSVLKLLSSAVAASPYVLVTIILAVKCYRARTDPDEDNRPYRVIEAEASV
Protein: Mitochondrial ribosomal protein S21, isoform A (Mitochondrial ribosomal protein S21, isoform B) (RE23482p) (Q8I0J3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein mS25
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein uS12m
- FI07234p
- GEO10172p1
Sequence:
MRHVQFLARTVLVQNNNVEEACRLLNRVLGKEELLDQFRRTRFYEKPYQVRRRINFEKCKAIYNEDMNRKIQFVLRKNRAEPFPGCS
Protein: DNA dC->dU-editing enzyme APOBEC-3H (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H) (Q19Q52)
Organism: Macaca mulatta (Rhesus macaque)
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18779051, ECO:0000269|PubMed:21653666, ECO:0000269|PubMed:21835787}.
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Chromosome 1 C1orf198 homolog
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
- Uncharacterized protein
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
Sequence:
MALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLKNKKKDHAEIRFINKIKSMGLDETQCYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWRPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLEELDKNSQAIKRRLERIKSRSVDVLENGLRSLQLGPVTPSSSIRNSR
Protein: Olfactory receptor 51E2 (Olfactory receptor 78) (Q8VBV9)
Organism: Mus musculus (Mouse)
Function: Olfactory receptor. The activity of this receptor is probably mediated by G-proteins wich induce elevation of intracellular Ca(2+), cAMP and activation of phosphorylation of the protein kinases PKA and MAPK3/MAPK1. Activation of OR51E2 may affect melanocyte proliferation, differentiation, and melanogenesis and may increase proliferation and migration of primary retinal pigment epithelial (RPE) cells (By similarity). Activated by the short chain fatty acids (SCFA), acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. May also be activated by steroid hormones and regulate cell proliferation (By similarity). Activated by L-lactate in glomus cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23401498}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q9H255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Free fatty acid receptor 3
- Guanine nucleotide-binding protein G
- Hydroxycarboxylic acid receptor 2
- Free fatty acid receptor 2
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
- Guanine nucleotide-binding protein G
Sequence:
MSSCNFTHATFLLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFFIHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHISVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMGDVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT
Protein: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein (Q9FJ65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box protein, putative
- Uncharacterized protein
- Leucine-rich repeat
- EG45-like domain containing protein 2
- Nudix hydrolase 6
- Germin-like protein subfamily T member 3
- At5g52160
- Protein DETOXIFICATION 32
- Gb|AAD55616.1
- CASP-like protein
Sequence:
MGKDNTRILMQFSALAMVLTAAIMVKEATSIPVCNIDTNDLAKCRPAVTGNNPPPPGPDCCAVARVANLQCLCPYKPYLPTVGIDPSRVRPLLANCGVNSPSCF
Protein: Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) (Q16878)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Interaction partners:
- 2-aminoethanethiol dioxygenase
- Cysteine sulfinic acid decarboxylase
- Acidic amino acid decarboxylase GADL1
- Cystathionine gamma-lyase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Putative aspartate aminotransferase, cytoplasmic 2
- Kynurenine--oxoglutarate transaminase 3
Sequence:
MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPNATSGSLENN
Protein: Glycine receptor subunit alpha-2 (P23416)
Organism: Homo sapiens (Human)
Function: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNC8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:Q7TNC8}. Cell membrane {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:26370147}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000250|UniProtKB:Q7TNC8}.
Interaction partners:
- RNA-binding protein Nova-1
- Gastrin-releasing peptide receptor
Sequence:
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
Protein: Peroxisomal membrane protein PEX13 (Peroxin-13) (Q95SJ3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Interaction partners:
Sequence:
MLDSTFFALTSSFRAILGVATNFVRLRSVFAQFWTTFAIFRGLNWMYRKILYWLRLSNLDPSSAAFKKAFAEALNENNGQARGAPNVPRKGNSPWPVLAFISFIFTAPYLIMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFVARSPSELSLRAGQMLHVAPRDIQQTLNLLNTGWALATTNGQTSGIIPISYVKSPQQMRQEMQDQTKPAQPQPELMNLSAGAFASPPLEQQMNYDFNLAAQQQAPLGPPSTTSAVLGEGFA
Protein: Cold shock domain-containing protein 4 (AtCSP4) (Glycine-rich protein 2b) (AtGRP2b) (Q38896)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chaperone that binds to and unwinds RNA and both single-stranded DNA and double-stranded DNA (ssDNA and dsDNA DNA) (By similarity). Regulates the flowering transition and flower and seed development, particularly at late stages of embryo development, through regulation of gene expression (including MEA, FIS2, AP1, CAL, AG and SHP2).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21282328}. Nucleus, nucleolus {ECO:0000250}. Nucleus {ECO:0000269|PubMed:21282328}.
Interaction partners:
- RNA exonuclease 4
- At2g15220/F15A23.4
- EEIG1/EHBP1 protein amino-terminal domain protein
- Oleosin
- At3g47680
- Probable receptor-like protein kinase At1g11050
Sequence:
MSGGGDVNMSGGDRRKGTVKWFDTQKGFGFITPSDGGDDLFVHQSSIRSEGFRSLAAEESVEFDVEVDNSGRPKAIEVSGPDGAPVQGNSGGGGSSGGRGGFGGGGGRGGGRGGGSYGGGYGGRGSGGRGGGGGDNSCFKCGEPGHMARECSQGGGGYSGGGGGGRYGSGGGGGGGGGGLSCYSCGESGHFARDCTSGGAR
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (E9PMD7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
Protein: Mannosyl phosphorylinositol ceramide synthase CSH1 (EC 2.4.1.370) (CSG1/SUR1 homolog 1) (P38287)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the synthesis of mannosyl phosphorylinositol ceramide. Catalyzes the addition of mannosyl to phosphorylinositol ceramide.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2
- Mannosyl phosphorylinositol ceramide synthase SUR1
- Inositolphosphotransferase 1
- Sphingolipid C4-hydroxylase SUR2
Sequence:
MKKELKILIIANIALLISIIHYTFDLLTLCIDDTSKDALTDEQLNPPNGFNSTFYESPPQLIPKIIHQTYKTNDIPEQWVKGRQKCIDLHPDYTYILWTDEMSDTFIKQEYPWFLDTFRSYEYPIERADAIRYFILSHYGGIYIDLDDGCERRLDPLLKVPAFLRKTSPTGVSNDVMGSVPRHPFFLKVIKSLKHYKKNWYIPYMTIMGSTGPLFISVVWKQYKRWSNTAENGAVRILQPADYKMHNNSFFSISKGSSWHTGDANFMKTLENHILSCVVTGFIFGFFILYGEFTFYTWLCSGPFNNKRYYIQWLSDKFKLHKWKLTSSYKNKEKRRNPTRHEYNSRGKRLRKDSNIPYDSVFLDIEKNHAKFTDLT
Protein: Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (O09110)
Organism: Mus musculus (Mouse)
Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 11
- Mitogen-activated protein kinase kinase kinase 5
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 13
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Mitogen-activated protein kinase kinase kinase 7
- Dual specificity mitogen-activated protein kinase kinase 6
- Mitogen-activated protein kinase kinase kinase 4
Sequence:
MESPAASPPASLPQTKGKSKRKKDLRISCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Protein: Centromere DNA-binding protein complex CBF3 subunit C (Chromosome transmission fidelity protein 13) (Kinetochore protein CTF13) (P35203)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as central component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly.
Subcellular location: Nucleus. Chromosome, centromere.
Interaction partners:
- Centromere DNA-binding protein complex CBF3 subunit A
- Suppressor of kinetochore protein 1
- Centromere DNA-binding protein complex CBF3 subunit B
- Histone H3-like centromeric protein CSE4
- Centromere-binding protein 1
- Inner kinetochore subunit CHL4
- Inner kinetochore subunit CTF19
- Protein SGT1
- Inner kinetochore subunit MCM21
- Inner kinetochore subunit CTF3
Sequence:
MPSFNPVRFLELPIDIRKEVYFHLDGNFCGAHPYPIDILYKSNDVELPGKPSYKRSKRSKKLLRYMYPVFATYLNIFEYSPQLIEKWLEYAFWLRYDCLVLDCFKVNHLYDGTLIDALEWTYLDNELRLAYFNKASMLEVWYTFKEYKKWVIDSVAFDELDLLNVSNIQFNIDNLTPQLVDKCLSILEQKDLFATIGEVQFGQDEEVGEEKDVDVSGANSDENSSPSSTIKNKKRSASKRSHSDNGNVGATHNQLTSISVIRTIRSMESMKSLRKITVRGEKLYELLINFHGFRDNPGKTISYIVKRRINEIRLSRMNQISRTGLADFTRWDNLQKLVLSRVAYIDLNSIVFPKNFKSLTMKRVSKIKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRIKELDKSEINQITYLRCQAIVWLSFRTLNHIKLQNVSEVFNNIIVPRALFDSKRVEIYRCEKISQVLVI
Protein: Hedgehog protein (F1LP42)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Secreted {ECO:0000256|ARBA:ARBA00004613}.; SUBCELLULAR LOCATION: [Sonic hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU280812}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU280812}.; SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane {ECO:0000256|RuleBase:RU280812}; Lipid-anchor {ECO:0000256|RuleBase:RU280812}.
Interaction partners:
- Patched
- Hedgehog-interacting protein
- Patched 2
- Protein smoothened
- Brother of CDO
- Cell adhesion molecule-related/down-regulated by oncogenes
- Growth arrest-specific 1.
- Sonic hedgehog protein
- Glypican-3
- Hedgehog protein
Sequence:
MSPAWLRPRLRFCLLLLLLLLVPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVHLETGERVALSAVKPGDRVLAMGEDGNPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAARFRATFASHVQPGQYVLVAGVPGLQPARVAAISTHVALGSYAPLTRHGTLVVEDVVASCFAAVSDHHLAQLAFWPLRLFPSLPWGSWTPSEGVHWYPQLLYRLGRLLLEESTFHPLGMSGAGS