wanglab/gogpt-training-data huggingface dataset:
Protein: N-terminal-borealin-like protein (Q3E7Y6)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment. Mediates the SLI15-BIR1 interaction within the CPC.
Subcellular location: Nucleus {ECO:0000269|PubMed:19158380}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19158380}. Note=In G1, localizes along nuclear microtubules and at spindle poles. In late S phase to metaphase, is seen as a few small nuclear foci and also localizes diffusely within the nucleus. Also found along the spindle in early anaphase, at the spindle midzone in late anaphase, and finally concentrated at the plus ends of depolymerizing microtubules before mitotic exit.
Interaction partners:
- Chromosomal passenger complex protein BIR1
- Inner centromere protein SLI15
- Aurora kinase
- Translationally-controlled tumor protein homolog
Sequence:
MIPALTPEERQKLRSAILHRMQLELETTEKLIENIKEETLKKLNLLQQPDATSAPQSKELIREVLEQEGRRIE
Protein: Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) (Q9BXA6)
Organism: Homo sapiens (Human)
Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q925K9}. Nucleus {ECO:0000250|UniProtKB:Q925K9}. Note=Component of the sperm flagellar doublet microtubules. Also localizes in the nucleus of elongating spermatids. {ECO:0000250|UniProtKB:Q925K9}.
Interaction partners:
- Heat shock protein HSP 90-beta
- Spermatid nuclear transition protein 1
- Heat shock protein HSP 90-alpha
- Testis-specific serine kinase substrate
Sequence:
MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG
Protein: Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 4 (A0A087WPJ3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
LREALAQKEDMEERITTLEKRYLAAQREATSIHDLNDKLENELANKESLHRQCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELSQRIAALTKAEERHGNIEEHLRQLEGQLEEKNQELARVRQREKMNEDHNKRLSDTVDRLLSESNERLQLHLKERMAALEEKGRLSEEIEKLRQEVDQLKGRGGPFVDGIHSRSHVGSAADVRFSLSTATHAPPGLHRRYSALRDESAKDWKPSPLPGVLGATTPAFDSDPEISDVDEDEPGGLVGTQVDVISPGGHSDAQTLAMMLQEQLDAINQEIRMIQEEKESTELRAEEIETRVTSGSMEALNLTQLRKRGSIPTSLTALSLASASPPLSGRSTPKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDKATIKCETSPPSSPRTLRLEKLGHPGLSQEEGKSALEGQDSNPSSSNSSQDSLHKGAKRKGIKSSIGRLFGKKEKGRLIQLSRDATGHVLLTDSELSLQEPMVPAKLGTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLATSTKTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLALVLQIPTQSTQARQVMEREFNNLLALGTDRKLDDGEEKVFRRAPSWRKRFRPRDHHSGGMLGTSAETLPAGFRVSTLGPLQPPPAPPKKIMPEAHSHYLYGHMLSAFRD
Protein: Casein kinase II subunit beta' (CK II beta') (DmCKII-beta') (O96863)
Organism: Drosophila melanogaster (Fruit fly)
Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Interaction partners:
- Casein kinase II subunit alpha
- Segment polarity protein dishevelled
- Suppressor-of-stellate-like protein
- Ste:CG33242
- Stellate protein CG33247
- Stellate protein CG33243
- Stellate protein CG33246
- Stellate protein CG33236/CG33240/CG33244/CG33245
- Stellate protein CG33238
- Stellate protein CG33237
Sequence:
MTDSDESSWIHWFCKQRGNEFFCEVDEEYIQDKFNLNFLDSNVKNYKCALEVILDLNPGSASEDPAEPELEASAEKLYGLIHARFILTNRGIELMLDKYNKGEFGTCPRAFCHSQPVLPIGLSDNPGEDMVRIYCPKCNDVYIPKASRHSNLDGAFFGTGFPHMFFMEKPDARPKRAKQKFVPRLYGFKIHPTAYRTAAEIQKDVTMTPVGEIDSPSHI
Protein: RNA-binding Fox protein 1, isoform L (M9ND74)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSASAVEVTGNVPPVEFHMREHMVQAGVAPFPGAPAGYAAAPNPGAAVVAAAAAAQQQQQQQQQQQQQQQQAQQQQQQQVAGGPPSAADSLSMAVAAAAAKQSADPVTQMKSGSEAAGSGNSNNNNTAGAGTGAPGAAGGLTTEYSSGGCGGGGASTANSVVVATSVSDVVNASLYMQQKSTVLIANEAAESQQSSAMQNAGGGGNTGGGGGGGGGGTPSSPLSNSPSSATASQAGGCGLTLNGSATEGSMSGDTSPVASGEPLLQTPPAHQQQQQQQQPLLCSSPTSMQSSGTSVTGSSIASGTLAATSSSGVGLLPTTGLDSIANGGAPTGCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSLSSALVPAQSVAAVAAASLDAKSQPKRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVVEGRKIEVNNATARVQTKKVTAVPNVCVQWPEAAVAAAMRGVAIQRGHVGVVGATPYHHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQQQQQQVAAAAQQQHQQQQQQQQQAVQQQQAVQQQQQHQQQQQQQQQQQHAAVAAAAAAASHPHMHAAHAHAHAHALGPQLAQLQAVAVPTAASNAAALQQSLAAAIQNPSGNPNAAAAAAAYAARLSAATGATQSPQTAAAAAAAASMAASANAANNAAALHGFAPVYYDPFLAAAASADPNLRFQAAKPVTEVPAAQPAAILNATAPLLKTPLSQAQQQAYATAATTYTAVAARAAYGAAAAAAAQPALAGYATVAGYAREYADPYLGHGIGPVPGYGATMYRGGFNRFTPY
Protein: Putative ATP-binding cassette protein subfamily (Q4QBD6)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Putative ATP-binding cassette protein subfamily H,member 3
Sequence:
MMAPQRKEARNAVPRSHHASSLSAATTLIAVFLLLVACASVTQALHVSPASAEAAMWSGTDVFASSDSHSDPITCVNGGIPSGDHCICPLYYTSANCSQRQCPNSVGGEGPHRVLPVNSTNKLCDHCDEKEFTGLSCQICQSNAACRQYAGSAAECDNSTFTRGDNKQFQCTLKNEFFVRLMSGNRNITAEVLFNCTTSDGTAFRKGEQGMCNMAIYRIEPNHSYVDPFFRCDAQACSLKYGQKGPDMSDANNNTLRQRFFRAARTAGQVALIVECALLALLGGFTALLGPRRTTSITVALASVITVTVLVYISLMMLSMQSISAPEQTVIYECKKTHCACAEDPPPQYDPICSQKEELSKQILPSIKNSIRVVCGQNTSLCELTLADLSLVFQADCRASECVDTVRFPDDSSSDSNDDGGGGTAVLAKLNLGFLLVLLVLLVVSGIGTHYYYTCSISYERDRDFLVTFHVSTPYSDDGDVHETGDPAVLDDRHVHLNGNADGSAVEREQEPLLYNSPAPRAERRNFLPRGVSSSRHSEGNVSVRASVYEQARALTPAARARIEELRRLTAAPLELQVSELRYTLNTPLLGAADEGSQRTLLHRINFTVHSGDVLAIMGPSGAGKTTLLDLLSARAKPGEVSGTITLNGTPITTTGSRTAQYRNIIGYVSQEDTLLPSLTVEQTILYAARLKLPKALSHITVRRIVARVIETLKLQHCAQTLIGGETTRGISGGEKRRVSIAVELLANPRILYLDEPTSGLDAVSAKRVVEAVVALAKDSAMSMYAMHYFAFQPIVIFSIHQPSQEIYELFDKVLLLSRGMSIYCGSAASAAATIERRVTAAFGHTREVPRREVHNNQAEYLMKVEEILDDAVRAELQEEDALENTDTAGAPYRSASADGSPLAAARTQVPPCRSPESPAPRAPSQSVGCHDSDDGEQVSGADILSTTFGFRMYYANVYEQLQLLISRSITCLFGSFHLVICHSAVVACLATLMCVLYHEQALDLPGSLNRAGSVSFLLLVTSFLSLSCLEQLIVERKLFNVERENGFYTTCPYLISKIVVDIIPLRIIPAVVLASVIYFPMGFRVDAGLHFFYFILIIVLFSICMTMVILCIGIVSGSFGAAALLSSVLILWNFVFGGALVQAETIPPSLRAFKSISPFFLAFESLMVNELDGQHCVFSPTDETGKKSSASIPIMCVQYLANIGLKPERFNADVMQLAVYCLLFVGLSWVLLSSCSKLVH
Protein: Zinc finger protein-like 1 homolog (Q9VD26)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGLCKCPKRLVTNQFCFEHRVNVCEHCMVQSHPKCIVQSYLQWLRDSDYISNCTLCGTTLEQGDCVRLVCYHVFHWDCLNARQAALPANTAPRGHQCPACSVEIFPNANLVSPVADALKSFLSQVNWGRNGLGLALLSEEQSSSLKAIKPKVASQAAVSNMTKVHHIHSGGERERTKPNGHDAVSPHSVLLMDAFNPPSAGDYASSRRPLLPRQSPIGGTDRDDNKYQRRTPAELFSRWTRRFYAPSSRPPWRRTWFLVTAGILAFVLFVYLMAWLGRGGSDAVDEGWNNPNPQPNHYE
Protein: Protein PSP2 (Mitochondrial regulator of splicing 15) (Polymerase suppressor protein 2) (P50109)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA polymerase alpha mutation suppressor. Suppressor of group II intron splicing defects of a mutation in MRS2. May play a role in mitochondrial mRNA splicing.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:23222640}. Cytoplasm, P-body {ECO:0000269|PubMed:23222640}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23222640}.
Interaction partners:
- Eukaryotic initiation factor 4F subunit p130
- Eukaryotic translation initiation factor 4E
- Protein PSP1
- PAB1-binding protein 1
- Small ribosomal subunit protein eS1B
- Small ribosomal subunit protein uS4B
- Serine/threonine-protein kinase RIO1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- ATP-dependent RNA helicase DED1
Sequence:
MGTNNTSNNNGTTKKMSLEEFLGNDTLGESVWDEEDINLDAISNTTNIDILKQTKAGEHQRDGHQQHPHGGHGPMNRSRFSNAGPFGGGSMGDFANHHHPLQHQQGPPYIVKFSDLPPRFSNFDIEDLFQAKFTKFIKFKLFWEINKNPSISTLKSGSIFDQNFKRDSKVAFVELYTSRDMDKILNYWTTPLKEIYHITTAPAEFEDFKDYSTKVKLLTDPKDDAGKPFITKTQRSKSNPFGSAKPVDTQSKILDIEEKMENLHVEDTTTLRASLIPSSDSMATTATGSKITILKKQTPTEEESHSATPTPKPLSYSEVVERSVVNETSKKGTPLSKLDSPALELQSKPDKSDEFKGGDEQGFEKGGDDKAQLDVSNDKDKGSETDVDKQFTFKNVEREHSMSRTKYNGNHNNNNGNFRGSNRYRGGPNGSSYKGGHNNRGNRGGYRGGSSYNNNNNNTNDNNNNNNNSSSNNNNGSRYHDRQNNEEGLTSDSSLDASGNKKNDFTNSTSNTQQYSIFKPASGFLGQGNNDSIRNNGRGNYNSSGMNGGSRGRGFGRGRGFGRGAYNNRGSRGGRGSSGNYSNYNNRTTDMPL
Protein: Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) (Q8VBW1)
Organism: Mus musculus (Mouse)
Function: Creatine:sodium symporter which mediates the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P48029}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P48029}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guanidinoacetate N-methyltransferase
- Glycine amidinotransferase, mitochondrial
Sequence:
MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPAGLGAPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Protein: Probable pectin methylesterase CGR3 (EC 2.1.1.-) (Cotton Golgi-related 3) (Q0WPN7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with CGR2, required for homogalacturonan pectins (HG) methylesterification in the Golgi apparatus prior to integration into cell walls, essential for general growth and development. Promotes petiole elongation. Impacts photosynthesis and respiration efficiency by influencing leaf mesophyll morphology and physiology; pectin methylesterification modulates both expansion and positioning of cells in leaves, probably by changing cell walls plasticity.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21422118, ECO:0000269|PubMed:25704846}; Single-pass membrane protein {ECO:0000269|PubMed:21422118, ECO:0000269|PubMed:25704846}.
Interaction partners:
- Probable pectin methyltransferase QUA2
- Zim17-type zinc finger protein
- AT3g15090/K15M2_24
- Probable pectin methyltransferase QUA3
- DEAD-box ATP-dependent RNA helicase 28
- Probable galacturonosyltransferase 7
- Galacturonosyltransferase 8
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase
- Galactan beta-1,4-galactosyltransferase GALS3
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 1
Sequence:
MSRRQVRRVGDSGSFPFVGALHSKSRSSPLLSVCLVLVGACLLIGYAYSGPGMFKSIREVSKITGDYSCTAEVQRAIPILKSAYGDSMRKVLHVGPETCSVVSSLLNEEETEAWGVEPYDVEDADSNCKSLLHKGLVRVADIKFPLPYRSKSFSLVIVSDALDYLSPRYLNKTVPELARVASDGVVLLAGNPGQQKAKGGELSKFGRPAKMRSSSWWIRFFSQTNLEENEAASKKFEQAASKSSYKPACQVFHLKPLH
Protein: Dof zinc finger protein DOF4.3 (AtDOF4.3) (Q9SUB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDNFNVVANEDNQVNDVKPPPPPPRVCARCDSDNTKFCYYNNYSEFQPRYFCKNCRRYWTHGGALRNVPIGGSSRAKRTRINQPSVAQMVSVGIQPGSHKPFFNVQENNDFVGSFGASSSSFVAAVGNRFSSLSHIHGGMVTNVHPTQTFRPNHRLAFHNGSFEQDYYDVGSDNLLVNQQVGGYVDNHNGYHMNQVDQYNWNQSFNNAMNMNYNNASTSGRMHPSHLEKGGP
Protein: Pre-mRNA-splicing factor syf2 (O59733)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor prp5
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor cwf12
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cwf3
- Pre-mRNA-processing protein 45
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cdc5
Sequence:
MDSPSHSREARVEKLKKIREQMRKSSHENRKEVVQEHSRMRIDPALERRLERKRMEAEEELAKIETEEEGGDFERRRAWDWTIEESEKWDQRLRKKKQTIQNVAFSDYHSQASKDYNRGIRDLKPDYEKYDKDKKEEKSKSRSVALYDEAERLDWVSNKPDKEHVERLVESIKKQDQRRLKNTKRRGTDEEDHITFINERNRKFNLKLQRFYSKYTKDIKEDLERGTAL
Protein: Uncharacterized protein Rv2923c (P9WL19)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein
- Acylphosphatase
- Chromosome partition protein Smc
- Uncharacterized protein
- Signal recognition particle receptor FtsY
- Probable antibiotic-resistance protein
- Probable carboxylesterase Culp7
- DUF4262 domain-containing protein
- Formamidopyrimidine-DNA glycosylase 1
- Uncharacterized protein Rv2927c
Sequence:
MTQLWVERTGTRRYIGRSTRGAQVLVGSEDVDGVFTPGELLKIALAACSGMASDQPLARRLGDDYQAVVKVSGAADRDQERYPLIEETMELDLSGLTEDEKERLLVVINRAVELACTVGRTLKSGTTVNLEVVDVGA
Protein: FI03293p (Kin17) (Q9VPH4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Splicing factor 3A subunit 2
- RNA-binding motif protein, X-linked 2
- Peptidyl-prolyl cis-trans isomerase
- UTP--glucose-1-phosphate uridylyltransferase
- Splicing factor 3B subunit 1
- Splicing factor 3B subunit 3
- BUD13 homolog
- Pre-mRNA-splicing factor 38
- Probable U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-processing factor 17
Sequence:
MGRAEVGTPKYLANKMKSKGLQKLRWYCQMCEKQCRDENGFKCHTMSESHQRQLLLFADNPGKFLHSFSKEFSDGYMELLRRRFGTKRTSANKIYQEYIAHKEHIHMNATRWLTLSDYVKWLGRTGQVIADETEKGWFVTYIDRSPEAMERQAKADRKEKMEKDDEERMADFIEQQIKNAKAKDGEEDEGQEKFTELKREENEPLKLDIRLEKKFQPDTVLGKSALAKRPAPEAEEKVFKKPKSVAGDSQTRSVLDEIIKQEESKKERANRKDYWLHKGIVVKFISKSMGEKFFKQKAVVLDVIDRYQGKIKFLETGEKLKVDQAHLETVIPALDKPVMVVNGAYRGSEALLRKLDERRYSVSVEILHGPLKGRIVDNVQYEDISKLHGA
Protein: Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) (Q9D855)
Organism: Mus musculus (Mouse)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041}; Peripheral membrane protein {ECO:0000269|PubMed:34616041}; Matrix side {ECO:0000269|PubMed:34616041}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome b
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 5A, mitochondrial
Sequence:
MAGRSAVSASSKWLDGFRKWYYNAAGFNKLGLMRDDTLHETEDVKEAIRRLPEDLYNDRMLRIKRALDLTMRHQILPKDQWTKYEEDKFYLEPYLKEVIRERKEREEWAKK
Protein: E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING-type E3 ubiquitin transferase CHFR) (Q5FWP4)
Organism: Xenopus laevis (African clawed frog)
Function: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Subcellular location: Nucleus, PML body {ECO:0000269|PubMed:15467728}.
Interaction partners:
Sequence:
MEGLDEKKPWGKLSRLLGAETDSSSELFLYKKEWTIGRKKACDLSFPGNKLVSGEHCKITVNEESGEVSLEDTSTNGTVINKLKVIRKQTYPLKNGDVIYVVYRKNEPEQNVAYLYKSLNQGQDSLHDPADTSGSEEAETQTLSSQDDQLSYEEPQPSTSTSSLFSTPTTSAIPGVQLESAEKSGESLGGHSSTSDASPAIRASIPKSNLSTQEQGSLGPPKKRIRTEDHWTTNKNFVPASCPIGASDESKTPSMKPDKMEETLTCIICQELLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYLIQHPEKCRSEEDRCSMDARNKITQDMLQPKVRRSFSDEEGSSEDLLELSDVDSESSDISQPYTVCRQCPGFVRHSMQPPPYPPPSDTETSRTQGDAPSTSTNFPTATQEYVCPSHGSHVICTCCFQPMPDRRAEREHNSHVAPQQCTICLEPFCHMYWGCNRMGCFGCLAPFCELNLGDKCLDGVLNNNNYESDILKNYLASRGLTWKDMLNESLAAVQRGVFMLPDYRINGTTVLCYFCGLRNFRILTYQYRQNIPASELPVTVTSRPNCYWGRNCRTQVKAHHAMKFNHICEQTRFKN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q7ZUN2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Anaphase-promoting complex subunit 4
- Cell division cycle 20 homolog
- Cell division cycle protein 27 homolog
- BUB1 mitotic checkpoint serine/threonine kinase Ba
- Anaphase-promoting complex subunit 1
- BUB1 mitotic checkpoint serine/threonine kinase Bb.
- MAD2 mitotic arrest deficient-like 1
- BUB1 mitotic checkpoint serine/threonine kinase
- Fizzy-related protein homolog
- Cyclosome subunit 8
Sequence:
MPSKTEDYEVLLTIGCGSYGKCQKIKRKSDGKILVWKVLDYGTMAEGEKQMLVSEVNLLRELKHPNIVRYHDRIIDRTNTTLYIVMEYCEGGDLASLINRSIKDKRYLEEEFILRVMAQLSLALKECHGRSNGSSTVLHRDLKPANIFLDAKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALSPPFTAYNQTELARKIREGRFRRIPYRYSDELNTLLSKMLNLKDYLRPSVESILQNGLISGYVALEQKRLQEKQRRRSDEAEQPKHPESPLLAELRLKEQILREREQALKEREQRLEQREQELCVREQQTNEKLVRAESMLKAFNLIRQQRALSLLSASDTENEENISPGKKRVHFAGDGKENGRLIMKPQEHILEKRHQLMNKRIQTLGEEEKMIHSPKHREMQGIR
Protein: Septin-8 (Q8CHH9)
Organism: Mus musculus (Mouse)
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Presynapse {ECO:0000250|UniProtKB:B0BNF1}. Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons. {ECO:0000250|UniProtKB:B0BNF1}.
Interaction partners:
- Septin-2
- Septin-5
- Septin-7
- Septin-4
- Septin-11
- Neuronal-specific septin-3
- Septin-6
- Septin-9
- Septin 12
- Septin-10
Sequence:
MAATDLERVSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEECVRLRPQTYDLQESNVHLKLTIVDAVGFGDQINKDDSYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRIHQEEKRKVEEKRRELEEETNAFNCRKAAMEALQSQALHATSQQPLRKDKDKKN
Protein: Import motor subunit, mitochondrial (EC 3.6.4.10) (Endonuclease SceI 75 kDa subunit) (Endo.SceI 75 kDa subunit) (mtHSP70) (P0CS90)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of the processed frataxin homolog YFH1 into the mitochondrion.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:2265609}.
Interaction partners:
- GrpE protein homolog
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM16
- Cytochrome c oxidase subunit 4, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM50
- Presequence translocated-associated motor subunit PAM17
- DnaJ homolog 1
Sequence:
MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINMKFSRAQFETLTAPLVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSRMPKVVETVKSLFGKDPSKAVNPDEAVAIGAAVQGAVLSGEVTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAAGQTSVEIRVFQGERELVRDNKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKDSSITVAGSSGLSENEIEQMVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKEFEGKVDKAEAQKVRDQITSLKELVARVQGGEEVNAEELKTKTEELQTSSMKLFEQLYKNDSNNNNNNNGNNAESGETKQ
Protein: Transmembrane protein 237 homolog (Joubert syndrome 14 protein homolog) (Q20687)
Organism: Caenorhabditis elegans
Function: Component of the transition zone in primary cilia. Required for ciliogenesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:22152675}. Note=Localizes the transition zone.
Interaction partners:
- Transmembrane protein 231
- TMEM
- Nephrocystin-1-like protein
- NePHronoPhthisis
- MecKel-Gruber Syndrome
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- Transmembrane protein 138
- C2 domain-containing protein
- Protein fantom
Sequence:
MPPTSRPVPPPPKRRISESSSSSDDELTGNNSFRENQQRRFRENNEVGNISDSDNDEVFSHQESQSVGFIETDEERQREEHAQNSNLRNRRVSYGKIPVPPMSMTVEDIQEAAKHSREDPSGETVEVRRPNDPRRSSVSLDVFKSFRDPHDKRNMPAKDKTIYVEGPNGKFREMKKGKFWNRDKFDSPKKDAEKKQDEDSVIPFLLKAPGQAYRTQRVYNQIANIIQGFLAGISVMLAIFSFNLEPEVLLTGYRYMSLPIHAGFMVAFTVGLVSAIDRTGIYEVEHFTSRTRLTATVYNNGLITFIVWFVGLVSTLLCIQLESQLAFAPTRIPSEDLVHHWRVFNVLRALTSGLGFLLLAFKPDSDTMAKELREAIYEQLELVTSDPERRRVIITAMKI
Protein: Copper-containing nitrite reductase (EC 1.7.2.1) (Q8KKH4)
Organism: Hyphomicrobium denitrificans
Interaction partners:
Sequence:
MIFHRFGAVVGLMMAALLSVPAAHADQHQQMAQKAAPAADAPAMKDKSKSHEEEKTDPTAGAHAPVVFTLRTGIAEGRMVYIGVGGDIDHKINPTLVVHEGETVQVNLVNGEGAQHDVVVDQYAARSAIVNGKNASSTFSFVASKVGEFNYYCSIAGHRQAGMEGNIQVLPGNRAEMKSSGADITRDPADLPGPIGPRQAKTVRIDLETVEVKGQLDDNTTYTYWTFNGKVPGPFLRVRVGDTVELHLKNHKDSLMVHSVDFHGATGPGGAAAFTQTDPGEETVVTFKALIPGIYVYHCATPSVPTHITNGMYGLLLVEPEGGLPQVDREFYVMQGEIYTVKSFGTSGEQEMDYEKLINEKPEYFLFNGSVGSLTRSHPLYASVGETVRIFFGVGGPNFTSSFHVIGEIFDHVYSLGSVVSPPLIGVQTVSVPPGGATIVDFKIDRAGRYILVDHALSRLEHGLVGFLNVDGPKNDSIMHEGPAKQ