wanglab/gogpt-training-data huggingface dataset:
Protein: Furin-like protease 1, isoforms 1/1-X/2 (Furin-1) (EC 3.4.21.75) (Kex2-like endoprotease 1) (dKLIP-1) (P26016)
Organism: Drosophila melanogaster (Fruit fly)
Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:8491178}; Multi-pass membrane protein {ECO:0000269|PubMed:8491178}.
Interaction partners:
- Matrix metalloproteinase-2
- ADAM10 endopeptidase
- ADAM10 endopeptidase
- Paramyosin, long form
- Matrix metalloproteinase 1, isoform C
- Protein serrate
- LD28763p
- Nicastrin
- Ankyrin, isoform B
- ADAM metalloprotease
Sequence:
MKNDVVRWSRQPTSNTTNSSSSSRSDSNSTHKHRSKSNKLNARQLGSNAARSCQQRSSVATTLEDEQQTIIECDIGNFNFDCNLFKTSFLTQHKQKRSGKSSSKSKSNRSRPLAKTKAVFLLALQFSAVVFLCNINVGFVAGSVATAASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPSVPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLGLSLLFFMIMQVFFLNFKHANDNNNKNKNNIIKCIR
Protein: Solute carrier family 22 member 4 (Zgc:66036) (Q6P695)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MRDYDDITSFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPEQINISSVWRDAAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIETEPCVDGWSYSQEFYQSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFSPSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAAYFIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPEVIFSSSEIEEAAKKRIQKHSILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLATALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIVIGGLALFSGVMSLLLPESKGKVLPETIAQMQSVRGLRRCRKPPAASTEDKSKVLQEVKL
Protein: Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Q8GRX2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03009}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit F
Sequence:
MDDWEAEDFQPLPSKVELKSNWDDEDVDENDIKDSWEEEDVSAPPPIVKPASEKAPKKPAVKAVEKKVKTVEAPKGTSREEPLDPIAEKLRMQRLVEEADYQSTAELFGVKTEEKSVDMLIPKSESDFLDYAELISQRLVPFEKSFHYIGLLKAVMRLSVANMKAADVKDVASSITAIANEKLKAEKEAAAGKKKSGKKKQLHVDKPDDDLVSGPYDAMDDDDFM
Protein: Protein nessun dorma (Q9VIP0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides.
Subcellular location: Midbody {ECO:0000269|PubMed:21187330}. Note=Detected in the midbody in late cytokinesis. Also detected in ring canals in testis and ovary and in the fusome. {ECO:0000269|PubMed:21187330}.
Interaction partners:
- Rac GTPase-activating protein 1
- Kinesin-like protein
- Deterin
- GTPase-activating protein RacGAP84C
- Chromosome associated protein G, isoform F
- Fascetto
- Australin, isoform A
- RE25723p
- Kinesin-like protein at 67A, isoform A
- Borealin
Sequence:
MEVFTFEKSYLERLKEAEAVLSWEGAVMPASQVRSEWKSYVELKIEPAGWQAIWKIPRVICEDLKLRYPTIVYGYVEQVIFDELKAVFVVTAVQDSDVHLPESNEVSLVELWPTVQQENAALNVDTTAECIDRLRFFYTHVWMPWDKDYDDDRDWVQQHLQARIQLVCDLSKNRLPRPLALHMRTLLAEAKYIQQRLDYLELDLSDAESDDEAVELNDSVAEPARKQSKAGSANGCLNVSSLPVTDLMCLHLRMAIIRSEFEILENPEMRRAYSELQSNSLKRLRCSSGRTRQSEDLLVERNSISHVVTLPGKLQQQLELLKLAQTLVKPESKVQLSNTLQDVLSICQSNDDILLSPGEHTIKFLEHLNDNGSLRGLTQPEAILSPAADLSLLPVVCSSDEDSTLLVIDGDYTLSELVLDCRHVRRGILLRNGTLTMRGCRLLGDGSSSTQEGIVCMPGASVELKSCLIENFAVGVSMRPKSSAELGSVQFKTCKTGLELLEKSASVNLQGSKCSFENCALGILADGFVLGEQRTEKVLVLNKFSELQRYNEDNLLGNCSFYNCKKNVRVFNESGQLLAQRSHQQLLEDELGGENKENIQLV
Protein: Transcription factor atf-6 homolog (Cyclic AMP-dependent transcription factor ATF-6 homolog) (Q20435)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Plays a role in the unfolded protein response (UPR), perhaps mainly during constitutive endoplasmic reticulum (ER) stress, by activating transcription of genes involved in the UPR. Plays a role in modulating lifespan, acting by positively regulating expression of calcium-binding chaperone crt-1, thereby influencing ER calcium homeostasis. By activating the UPR pathway, confers adaptive protection to subsequent exposure to hypoxia. Involved in protection against proteotoxicity, probably acting via the UPR. Probably acts in the UPR in parallel with the ire-1-xbp-1 and pek-1 pathways. May be regulated by endopeptidase S2P-mediated proteolytic cleavage.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- BZIP domain-containing protein.
- Eukaryotic translation initiation factor 2-alpha kinase pek-1
- Transcription factor atf-4 homolog
- Membrane-bound transcription factor site-2 protease
- Eukaryotic translation initiation factor 2 subunit 1
- Calreticulin
- Heat shock protein 70
- Endoplasmic reticulum chaperone BiP homolog
- Calnexin
- Eukaryotic translation initiation factor 2-alpha kinase gcn-2
Sequence:
MNFDNTVHESNFDDLLHNPNFPPQFDQLELDSLLYGTDESQESTSSSSFGFSDQNAGFRSRDGGSLGDSSSDSSPPLSCANFTENDQEMWDFGFQSRSPFENFEQQFGSPYQDDEVIAEPTNEFMNARYLREEPAKHLPMQQKRIITILPKQSQPVKRIVSRPIQKVYRVKESPGSQQQTYRVVQPLMPSPSQATQRQIKQMYYNEPVQEIHMQPKSGPLVRQVSEEPRYVPIAPTVDIKAEPQVFTSEQNRKIRNRMYAQASRMRKKEADEHMKMNLQELLQENEILRTENAALKQRLAFFEHEEPVVEVPQPFGRNQKKKRIIAAGSVLMMFGLFAVISPFNVDNNLNINNQIMAISNETSMVARHGRVITYEDSAPVAKIPTQQPIHNYPNSTQNDCDMYKLNATETIRVNNDIERWVQVHSFDNVPMKFSGGLLNKEAMRKFNYAQKVKPASVYGPQTLAVQKKSEQAALRSRERTWKQLDLLKTGNNIQLDNEKIQRKRQDIDKIASIVRQKGDTLYIMTLQDYVLLPSLIKGANSVPKLSLLLPSVPMNGTLQDQYTLLRVDCEVTGTGQLTLSNKQLSYLMP
Protein: Basic-leucine zipper (BZIP) transcription factor family protein (B3H7M2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
- Alcohol dehydrogenase transcription factor Myb/SANT-like family protein
- Choline transporter-like protein
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta
- Serine/threonine protein phosphatase 2A regulatory subunit B''beta
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''epsilon
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- bZIP transcription factor 27
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Sequence:
MGGGGDTTDTNMMQRVNSSSGTSSSSIPKHNLHLNPALIRSHHHFRHPFTGAPPPPIPPISPYSQIPATLQPRHSRSMSQPSSFFSFDSLPPLNPSAPSVSVSVEEKTGAGFSPSLPPSPFTMCHSSSSRNAGDGENLPPRKSHRRSNSDVTFGFSSMMSQNQKSPPLSSLERSISGEDTSDWSNLVKKEPREGFYKGRKPEVEAAMDDVFTAYMNLDNIDVLNSFGGEDGKNGNENVEEMESSRGSGTKKTNGGSSSDSEGDSSASGNVKVALSSSSSGVKRRAGGDIAPTGRHYRSVSMDSCFMGKLNFGDESSLKLPPSSSAKVSPTNSGEGNSSAYSVEFGNSEFTAAEMKKIAADEKLAEIVMADPKRVKRILANRVSAARSKERKTRYMAELEHKVQTLQTEATTLSAQLTHLQRDSMGLTNQNSELKFRLQAMEQQAQLRDGMHIIKTLSEKLNEEVQRLKLVIGEPNRRQSGSSSSESKMSLNPEMFQQLSISQLQHQQMQHSNQCSTMKAKHTSND
Protein: Ribosomal RNA small subunit methyltransferase mra1 (EC 2.1.1.-) (18S rRNA (pseudouridine-N1)-methyltransferase) (Multicopy suppressor of ras1-deficiency protein) (Q10107)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Essential for cell growth. It also has a key role in promoting the mating function.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06287}.
Interaction partners:
- Probable nucleolar complex protein 14
- Nucleolar protein 58
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 6
- Uncharacterized protein C1604.06c
- U3 small nucleolar RNA-associated protein 4
- U3 small nucleolar RNA-associated protein 22
- U3 small nucleolar RNA-associated protein 10
- rRNA-processing protein fcf1
- Periodic tryptophan protein 2 homolog
Sequence:
MPTYSKRKSRGSLEVSEKTNQPKFIKRSQSSETITSGETASELMQDEKEQSNGAVGSIEDEELQRLRENQASVEALSKKPESIDRELGVEALEIDNVVKSDEEKEDPNGASSKTVKARPLPAGSVHRVTTHMAPIPARSIGSHDTTTQRLIVVLDQACLEIYKVGKAKDAKYQLLNCDDHQGILKKLNRNIAQARPDITHQCLLTLLDSPLNKAGRLQVYIHTAKKVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSVNGNEKLLKVIKNPVTDYLPPNCRKATLSFDAPTVPPRKYLETLQPNQSVCIAIGAMAHGPDDFSDGWVDEKISISDYPLSASIACSKFLHSMEDFLGIV
Protein: L-serine ammonia-lyase (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (F8VXS0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDDRKRAKRKSSYREQQPGPPRGRNALWGAADADRRGLGQERRGFTMLAGLKLLSSSDLPTSASRSAGTTSVSHRAQPFERFEAEELCVNGPVGMMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLI
Protein: Protein REDUCED CHLOROPLAST COVERAGE 2 (Protein TPR-domain suppressor of STIMPY) (F4JKH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negatively regulates meristematic tissue proliferation by integrating developmental signals with carbon source availability. May act as the scaffold of a protein complex, which sequesters key factors that are required for the G2 to M transition in meristematic tissues. Together with REC2, REC3 and FMT/CLU, contributes to the establishment of the cellular volume devoted to the chloroplast compartment.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:F4HS99}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:F4HS99}.
Interaction partners:
- NHL domain-containing protein
- VQ motif-containing protein 4
- Protein IQ-DOMAIN 14
Sequence:
MAPKAGKTKPHKSKGEKKKKEEKVLPTVIEISVETPDESQVTLKGISTDRILDVRKLLAVHVQTCHFTNFSLSHQVRGTKLKDSVDIVSLKPCHLTIVEEDYTEEQATAHIRRLLDIVACTTAFGPSKPPVSRTLPKDSEKKESGSTDGDSPTEKDAGDSNSGLSPKPKESEKKSVGACEAQSAEGAAKSDIDMCPPTRLGQFYEFFSFSYLTPPIQYIRRSVRPSKEDKGLDDLFQIDIKVSSGKPFTVVASRTGFYPPGKQQLLCHSLVELLQQISRPFDAAYDALMKAFIEHNKFGNLPYGFRANTWVVPPVVADSPSTFPSLPVEDETWGGDGGGVGRSGKYDKRKWAKEFAILAAMPCKTPEERQVRDRKAFLLHSLFVDVSVFKAVEIIKKIVENNQCSLKDPAALGFHEERIGDLIVRVARDDPDASAKLDRKSDGTQVLEISQEELAQRNLLKGITADESATVHDTSTLGVVVVRHCGCTAIVKVASEFKLNDGHILQDIDIEDQSEGGANALNVNSLRTLLHKSSTPSSLAQRSPNADSEQIRVAKSLVRKVIEDSLKKLEIEPSRYSKPIRWELGACWVQHLQNQASSKSESKKTEDPKPEPAVKGLGKQGALLKEIKRKIDVKANKTEQGKEAPANDTDNTSETEDQKELEKQNEEIEKMWKELVTETAYQRLKESETGFHLKSPKELIEMARKYYTDTALPKLVADFGSLELSPVDGRTLTDFMHTRGLQMHSLGRVVELAEKLPHVQSLCVHEMIVRAYKHILQAVVAAVENTADVATSIATCLNVLLGTPSDTESVYDEKIKWTWVETFISKRFGWDWKHEGCQELRKFSILRGLSHKVGLELVPKDYEMDTSYPFKKFDIISMVPVYKHVACSSADGRTLLESSKTSLDKGKLEDAVNYGTKALAKLVAVCGPYHRMTAGAYSLLAVVLYHTGDFNQATIYQQKALDINERELGLDHPDTMKSYGDLAVFYYRLQHTELALKYVNRALYLLHLTCGPSHPNTAATYINVAMMEEGMKNAHVALRYLHEALKCNQRLLGADHIQTAASYHAIAIALSLMDAYSLSVQHEQTTLQILQAKLGPEDLRTQDAAAWLEYFESKALEQQEAARNGTPKPDASISSKGHLSVSDLLDYITPDSGIKARDAQRKARPKVKGKPGQSPGPVSEENQKDDEILSPAHLTGESSSDKENKSETKSEEKKVENFDLEQSKPQDQLKLVKPEATVHEDDDSDEGWQEAVPKNRFSSGRRTRPSLAKLNTNFMNVTQQPSRSRGKSTNFTSPRTSSNELSISVAGSTSSPASKMFVKSPLNKKQNNSSVVGERPVNDKSALASSACTEQINKPTPMLSPVSVKAGKLFSYKEVALAPPGTIVKIVAEQLPEETKAPQNLDAAKIAVDGPEKVNAQDAESENKHVATETEAENTDCNEQGRVVVGGSELTSSPKEIKNVEVEKAAEKAFPIETAVSNARPGKSKSAQMAEDSDTCLLNKSPTANDSNGSESVIGVKLQKDLCDAELKTVDGETENLPNGDSSPKSSVAADGEKQDACEAQKEMSKKLSASAPPYTPTTIPIFGSIAVPGFKDHGGILPSPLNMPPMLPINHVRRSTPHQSVTARVPYGPRLSGGGYNRSGNRVPRNKPSFPNSTESNGEANQFNGPRIMNPHAAEFIPSQPWVSNGYPVSPNGYLASPNGAEITQNGYPLSPVAGGYPCNMSVTQPQDGLVSEELPGAGSSEEKSGSEEESNNDKNAGEDDEAVGQETTDTPENGHSTVGEVETTSHETCDEKNGERQGGKCWGDYSDNEIEQIEVTS
Protein: B-related factor 1 (Q9NG52)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSTGLKCRNCGSNEIEEDNARGDRVCMNCGSVLEDSLIVSEVQFEEVGHGAAAIGQFVSAESSGGATNYGYGKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQHYADTALNFFKMALGRHLTRGRKSTHIYAACVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCINIPSLDPCLYIMRFANRLQLGAKTHEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFSRTMLDVIGVVKIHESTLRKRLSEFAETPSGGLTLEEFMTVDLEREQDPPSFKAARKKDRERIKDMGEHELTELQKEIDAHLEKDLGKYSNSVYRQLTKGKGLSPLSSPSTPNSSSEKDIELEESRQFIEQSNAEVIKELIAKNEDVKKSEPGGLVAGIEGLRPDIEAICRVTQSDLEDVEKAKQPQEQELITDDLNDDELDQYVLTEEESVAKLEMWKNLNAEYLQEQKERDERLAKEREEGKPERKKRKPRKKVIGPSSTAGEAIEKMLQEKKISSKINYEILKTLTDGMGGLTDDSPTTSADTKPSTLEELKHQPVIVEEGPVPSKSRGNRAAYDLPGPSRKRPKLEVGLPVSQAADVEQPETKPAVVVEADDLDEDADDPDVEPEAEPEATLQDMLNTGGDDDEFGYGFDEEEEY
Protein: NADH:ubiquinone oxidoreductase subunit C2 (E9PRJ5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004298}; Matrix side {ECO:0000256|ARBA:ARBA00004298}.
Interaction partners:
Sequence:
MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATADKKTYGEIFEKFHPIR
Protein: Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) (P43577)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Phosphoacetylglucosamine mutase
- Glutamine--fructose-6-phosphate aminotransferase
- UDP-N-acetylglucosamine pyrophosphorylase
- Putative glutamine--fructose-6-phosphate aminotransferase
- Hexokinase-1
- Glucokinase-1
- Hexokinase-2
- N-acetylglucosamine kinase
- Putative glucokinase-2
- Fumarate hydratase, mitochondrial
Sequence:
MSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFSKLIKYWNEATVWNDNEDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK
Protein: Rae-1-like protein (C5IXG6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MEGGVQAPSLTGRPSRVAVILTEGQASYKVPDNCWSYSVGDRHFRESLSGILCGAAQNPHGFSQLRSHLLLRAGMAENTAAEHPLFTGASCVLVFLSCLGSTLCADVHSLSCNLIIRSPTKAEPLWYEGQCSMDGNVFLSSNNVNKTMPLGNQEKMANATEVWTCLTQWIDRCKQDLRDKVSEIKGDTTKTSGHPTLRVTMLSNHSHEQIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDKTLMKHLNLFIVECSPKFNEFLNQHEERTRSTTRAPDITQPPPTSQVPYKEVLIPVGLIISIIFIIFLCICVKRMCCPHGGRELQLLKDYCINWHKPQRNEGLEETKGEVPNQRTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS
Protein: Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9) (P36969)
Organism: Homo sapiens (Human)
Function: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism. Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
Subcellular location: [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:O70325}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:11115402}.
Interaction partners:
- Glutathione reductase, mitochondrial
- Peroxiredoxin-6
- G-rich sequence factor 1
- Glutathione-specific gamma-glutamylcyclotransferase 1
- Endoplasmic reticulum chaperone BiP
- Glutathione S-transferase omega-2
- Glutathione S-transferase P
- Glutathione S-transferase omega-1
- Glutathione synthetase
- Hematopoietic prostaglandin D synthase
Sequence:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
Protein: Bacterial ferritin (FtnA) (EC 1.16.3.1) (Bacterial non-heme ferritin) (Bacterioferritin alpha subunit) (BFR alpha subunit) (Nonheme-iron-containing cytochrome b557) (Q9HWF9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:35327558, ECO:0000269|PubMed:7998985}.
Interaction partners:
- Bacterioferritin-associated ferredoxin
- Heme oxygenase PigA
- Ferrochelatase
- ferroxidase
- Bacterioferritin BfrB
Sequence:
MQGHPEVIDYLNTLLTGELAARDQYFIHSRMYEDWGFSKLYERLNHEMEEETQHADALLRRILLLEGTPRMRPDDIHPGTTVPEMLEADLKLERHVRAALAKGIALCEQHKDFVSRDILKAQLADTEEDHAYWLEQQLGLIARMGLENYLQSQI
Protein: Putative myc-like protein MYCLP1 (Protein L-Myc-2) (V-myc myelocytomatosis viral oncogene homolog pseudogene 1) (P12525)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MDRDSYHHYFYDYDGGEDFYRSTTPSEDIWKKFELVPPPWDLGPAAGNPALSFGLLEPWPVGCAGDETESQDYWKAWDANYASLIRRDCMWSGFSTQEPLERAVSDLLAVGAPSGYSPKEFATPDYTPELEAGNLAPIFPCLLGEPKIQACSRSESPSDSEGEEIDVTVKKRQSLSTRKPVIIAVRADLLDPRMNLFHISIHQQQHNYAAPFPPESCFQEGAPKRMPPKEALEREAPGGKDDKEDEEIVSLPPVESEAAQSCQPKPIHYDTENWTKKKYHSYLERKRRNDQRSRFLALRDEVPALASCSRVSKVMILVKATEYLHELAEAEERMATEKRQLECQRRQLQKRIEYLSSY
Protein: Calmodulin-dependent protein kinase (EC 2.7.11.17) (Q5ZTM4)
Organism: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- diguanylate cyclase
Sequence:
MVYYINLKEQPLHQDKEILTQLIKQYLLSGSSQSALFANHPYTLNDEDGNEIEFLLSHDIYKNQREDGITEFLILNGSQIGRGTKGVVIQSNHAMYLIDDELVIFPKENVLKVLYQNFINAEELIKQESVNYSILSGNSTAELVNLQGGNQGFFMQKEEGYALEELLEDIDSLQKLTFSDKMELAISFLTELENLHNKGYAHGDLTFKNILYNEKNNQLKIIDAGEMKVADERFWAQDISIAIEMISLLFTTNETNQFKASRYWSDEPTVRRIVNPNPVEAKLNRILNSEYRCVSDLKLAIERNYNEYLNNSNLVLKKNVELESEALGLQAYKNQMSKQQLLGEIQGFKENYWNMKDLLTLTNRHHLRVFLEYLDNICSAFKDDKTDEKSARAAYDFLNAQINKLFEDNSKNSKPSFESFSEDVQRFLIHIDTYLMKNPSACSNSIASTIQLLKQLDNKKSFNPEQSFKDFCSYKEITIQLLLKPFETPVAEMASAPAIASDLIEKQSDTKRKLQEMKSSANQDKQPIFTPSLMRGPS
Protein: Uncharacterized transcriptional regulatory protein PB24D3.01 (Q9C0Z1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative agmatinase 3
- Uncharacterized transcriptional regulatory protein C139.03
- Uncharacterized membrane protein C3H7.05c
- Putative agmatinase 1
- Zinc-type alcohol dehydrogenase-like protein PB24D3.08c
- Uncharacterized protein UNK4,15
- Uncharacterized transporter C11D3.06
- UPF0613 protein PB24D3.06c
- Uncharacterized transcriptional regulatory protein C1399.05c
- Putative uracil phosphoribosyltransferase urg2
Sequence:
MTSVEKASKACELCRRKKIRCNRELPSCQNCIVYQEECHYSKRLKRSYSATKKKNGNPVLESAIPSLSPSPSIENGSAMLNSDITSLSNRIFKVEEKLDLILSLLKNSSEPLDRTERKDFPSLAMQIRDANSLVNTKLKEYSRRFELPSQKTSFDDLFSSTFPNFDAAFKDIPDKEWAFENVQWYFRYINCWWPVFYEKDFMDEYECLYRDRNQVKGAWLVSFYSVLALAASRSKAGKDQKLAESFFSTSWYLIQKPGFFLTPQLEKIQALLIMIQFAAHVSLHTLCKALCGQACLMIRDLNLHRESANADFSNKDAELRRRVFWICYIFEITTSLVFGTPSVLSDMDIDCEHPNYEYGRYFSEMPTGDLIFSSEVSLTILKNEVRTKVYSRTNTSNARNREKAIWQIHEKLLCWERALPIELRQYFIALTENAQIYEELDFEKQRLFSACIEVYLSYCNTLIFLHRLNESVEGANICLDTARRAINVLKFFFIIPIAKNVCYLWVFLYCPFTPFLVLFSNIVNGKEPSTDIAFEDLNRMYSVNRFFVKLRDIGGDLAEKLASVTENFIHAAENYFAVQPAFMADAFDFASFLT
Protein: Autophagic-related protein 16.2 (Q09406)
Organism: Caenorhabditis elegans
Function: Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Plays a role in the recruitment of lipidated lgg-1 probably to the autophagosome membrane to promote autophagosome formation. Furthermore, association with atg-5 is required for the nucleation of lgg-1 positive autophagosomes. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.1 to regulate autophagic processes. In a daf-18/PTEN- and daf-16/FOXO-dependent manner, required for maintaining the numbers of germ stem cell progenitors in the gonad during the late phases of larval development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24185444}. Cell membrane {ECO:0000269|PubMed:24185444}.
Interaction partners:
- Autophagy-related protein 18
- Autophagy-related protein 5
- Ubiquitin-like protein atg-12
- Ubiquitin-like-conjugating enzyme ATG3
- Autophagy-related protein 11 C-terminal domain-containing protein
- Ras-related protein Rab-33
- Autophagic-related protein 16.1
- Beclin homolog
- Protein lgg-1
- Protein lgg-2
Sequence:
MTDNRTSFRLEILNRLCKRERQQRCVKDMFKNYSLLDEQLQQSHRSRSVSVNDEHFKGNVNDRLAVMKEEMANVYRMKSKNDQDLIDANRKLADSESRYSLVSSQRDKLRIETDAIVKKMTVLENELAELKEENSVINTERVSLVATCNYLTEKKTQLDNERFQLLNRIRELQEKSAEFMNAEIALQEERAQMRIREQIAKATADLNLGDERASSAFGTSPETLDEFMMTDVLPSEVKFKLSTHDGEVHDVEWMSDDTFATAGSDSKVQIWRVSPNKTDASKVSTLSGCLGPVNRLDYDSQRHVCLASSNDKTCRLWNIDSQRLLSTFSGHTDKVSSARLFQSHNVISGSADRTIKNWDISSIRCLKSYLVGSTVFDIVAKCGVSQSSFISSHFDKKVRFWDARSSDATYSVELGQKVSSLDISMDGLQVLASSRDDTLSLIDVRNYGIIHLYSAEQYKTSCDSTRAIFSSTGEYVLAGSSNSSVFIWNTKTTKLEKVVKTARSDSAQIMSLAWNPSGRGLLACDRQKTCTLWR