wanglab/gogpt-training-data huggingface dataset:
Protein: Pentatricopeptide repeat-containing protein 5, mitochondrial (Q10451)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial RNA-binding protein that acts as a general negative regulator of mitochondrial translation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:21727087}.
Interaction partners:
- Mitochondrial cox1 translation regulator ppr4
- Pentatricopeptide repeat-containing protein 6
- Pentatricopeptide repeat-containing protein 2
- Cytochrome b
- Protein mss51
- ATP synthase subunit a
- DNA-directed RNA polymerase, mitochondrial
- Cytochrome c oxidase subunit 1
- Pentatricopeptide repeat-containing protein 8
- Cytochrome c oxidase subunit 2
Sequence:
MVYTKAWFLQNIARQTLGKNVAVHRPPLKLGNMTNWIQQQQAQTNLSLSNTKAPGSLDERLFLTEDDIIFHDRSIQLGYFDPSLSERKQSPPGKSLHRFVDNLNPNSSHFSASLLPASLSSLCDSTCGDVDDEQQFNSLATSPLSTETQSEVSDPLLDTLTPNSLESSFASISLNSFTSANEFIQFLKRLASSKLSIHTFDLYKLVRNSPELLTLEAYNIVLQCMSTDDYFLSSSKNIQKIIKVYVDMLNSFISPNVTTFETVIFALCRRAKFVHQKIESLSKRTIYAHPSIAKEIQPELLDLQSEMPLQTAVFMFTSSLINHDLIYSPQFYAILIESVSLYGTQSQLDSLLECVPLGTIEANGHPDLLPALIRALGRAKRLNSCFQLLERYNLSDPTSDTSMTNVRSWEGLMEAYFDTDHHVEASALMKSFFRKADSNQVIPSSILDCFLRRLAQLGHYKESAEWLGMAIEKISTYKASPSTLSSILEAACLNNNDKFAIAFVRKYTLSRFSDCHAVLLRYLDLLARSGNVDLLHLHAYPVICSVSSHTNFTFSNVYKAFIENGKIDVALRLLRKHIDPKVSLGNNTAPSSNSVALQLSILNGFWEVLTEELQKDVHVLLSLVSTLENQVNFPQVDFTTPLLRHITGYLVSRRLEPELISPRVFGFLLEYAAFNVVQTEGTFTSKVILTDLLKCYSNGTYKASFKNVHVVLRSFTYLKEDEMLVASVRDDIVSEAVVGFSTDNNGQKILADISQVCYCLDDLECIDQSINSLVSKMLTSASPEQVDVNILFFQFGKLIETNKFLHPEVYPTLISVLSKNKRFDAVQRVFEHSKHLYRKISTKSLEKANWFMALILDAMILSSSFARQFKSSNLFCDNMKMLGYIPRASTFAHLINNSTRRGDTDDATTALNIFEETKRHNVKPSVFLYNAVLSKLGRARRTTECWKLFQEMKESGLLPTSVTYGTVINAACRIGDESLAEKLFAEMENQPNYQPRVAPYNTMIQFEVQTMFNREKALFYYNRLCATDIEPSSHTYKLLMDAYGTLKPVNVGSVKAVLELMERTDVPILSMHYAAYIHILGNVVSDVQAATSCYMNALAKHDAGEIQLDANLFQSQIESLIANDRIVEGIQIVSDMKRYNVSLNAYIVNALIKGFTKVGMISKARYYFDLLECEGMSGKEPSTYENMVRAYLSVNDGRKAMEIVEQLKRKRYPLPVVNRISSLVNSHMGQKPKRRSLNTSHSSLASLGNASTQHSINSSIN
Protein: Tubulin delta chain (Delta-tubulin) (Q383I6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Spindle pole body component
- Spindle pole body component
- Gamma-tubulin complex subunit, putative
- Gamma tubulin complex component protein N-terminal domain-containing protein
- Katanin p60 ATPase-containing subunit A-like 2
- Serine/threonine-protein kinase PLK
Sequence:
MACVHVLVGQCGNQLGAHFLTALTDEARRCSDEDYASQISADHFRPAPTQKGIRRGGVSNGNSGHHDEPPLPRSVMIDMEPKVVESVVTGVNDGGAFQVRAEQCVTRDEGSGNNWAFGYYEQGRSRCDEIVESLRRQSEARGAAHSFHIVHSVAGGTGSGVGCLVSDAIRVEFPRALLLHTAVWPFATGEVVTQWYNCVLAMSALRESADAVFVAHNDDFDVSARPLQKAVNGRTSEVSFDTINHEIGRLLLDLHLPKKLYPVPSTAPEKKPHPQSTFPASRTTSSTGAMASLRCGGLTDVVEAVALDPALKFFSGLALPVTPPDNRVVAPEATSWYPLLCEASRRTSELFVPAPSGDNNTSNNLSTAFIEQRPLLWSLRGPAACSEGLAHLREVLSRSTPTPDGRELYVPPSALLLHEERLLGRRAHVSVFGPTHNIGLRLASALERAEDLLRVSAYVHHFSRYGVGEEELRDAVVRMWDTAAAYGAA
Protein: Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) (P50569)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Nuclear receptor subfamily 0 group B member 1
- Nuclear receptor subfamily 0 group B member 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Catenin beta-1
- Steroidogenic acute regulatory protein, mitochondrial
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Muellerian-inhibiting factor
- Nuclear receptor coactivator 2
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
Protein: Zinc finger protein 609 (Q8BZ47)
Organism: Mus musculus (Mouse)
Function: Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.
Subcellular location: Nucleus {ECO:0000269|PubMed:28041881}.
Interaction partners:
- E3 ubiquitin-protein ligase SHPRH
- Eukaryotic translation initiation factor 4 gamma 2
Sequence:
MSLSSGACGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDASKPTPGTSLFSPSEGAASKKEVQGRAGDGASAGGLVAAVAPKGSEKAAKASRSVAGSKKEKENSSSKGKKERSEGVGTCSEKDPGVLQPVPLGGRGSQYDGSAGMDTGTVEPLGSIAIEPGAALNPLGTKPEPEEGENECRPLKKVKSEKMESPVSTPAVLPLHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPSSNTPVSEAAAASDSKGTSSSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKSKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTLVDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPALHADLSCNGAPVPQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDPGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKSEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTTTVVQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKDSSKELESPLTPGKVCRAEEGKSPFRDAAGDGIKVESLLNGSSESHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLDSTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSAKSKDPEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPGYAQSSPGTLTSSSQAGMEGQPLKTKKDEEPESVEGKVKNDVCEEKKPELSNSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHSHLLSTNTAYRQQYEEQQKRQSLEQQQQQQRGLDKKTEMGLKEREASLKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGTDPAKSVIIPKLDDSSKLPSQPPEGLKGKLGEASHLGKEASEAKTGTECGRQAEVDPILWYRQETESRMWTYVYPAKYSDIKSEDDRWKEERDRKLKEDRSRSKDSVPKEDGKESTSSDCKLPPSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRGMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVSCKASSESKALDILQQHASHYKSKSPTISDKNSQERDRGGCGVVGGGGSCGSVAGAGGTDRSADRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR
Protein: SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (P98077)
Organism: Homo sapiens (Human)
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Interaction partners:
- Epidermal growth factor receptor
- Vascular endothelial growth factor receptor 2
- BDNF/NT-3 growth factors receptor
- Proto-oncogene tyrosine-protein kinase Src
- Receptor tyrosine-protein kinase erbB-2
- Receptor tyrosine-protein kinase erbB-3
- Receptor tyrosine-protein kinase erbB-4
- Growth factor receptor-bound protein 2
- High affinity nerve growth factor receptor
- Mast/stem cell growth factor receptor Kit
Sequence:
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP
Protein: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) (P9WMS7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the synthesis of GMP from XMP.
Interaction partners:
- Inosine-5'-monophosphate dehydrogenase
- GMP reductase
- Uncharacterized oxidoreductase Rv3410c
- Adenine phosphoribosyltransferase
- Arginine--tRNA ligase
- Guanylate kinase
- CTP synthase
- Large ribosomal subunit protein uL11
- dITP/XTP pyrophosphatase
- Hypoxanthine-guanine phosphoribosyltransferase
Sequence:
MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE
Protein: Mitogen-activated protein kinase 13 (AtMPK13) (MAP kinase 13) (EC 2.7.11.24) (Q9LQQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MKK6-MPK13 module positively regulates lateral root formation.
Interaction partners:
- Mitogen-activated protein kinase kinase 6
- Mitogen-activated protein kinase kinase 2
- Protein-tyrosine-phosphatase PTP1
- Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein
Sequence:
MEKREDGGILTYDGRYVMYNVLGNIFELSSKYIPPIEPIGRGAYGIVCCATNSETNEEVAIKKIANAFDNRVDAKRTLREIKLLSHMDHDNVIKIKDIIELPEKERFEDVYIVYELMDTDLHQIIRSTQTLTDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLVLNTNCDLKICDFGLARTSNETEIMTEYVVTRWYRAPELLLNSSEYTGAIDIWSVGCIFMEILRRETLFPGKDYVQQLKLITELLGSPDDSDLDFLRSDNARKYVKQLPHVQKQSFREKFPNISPMALDLAEKMLVFDPSKRITVDEALKQPYLASLHEINEEPTCPTPFSFDFEETALDEQDIKELVWRESLHFKNM
Protein: Putative odorant receptor 85e (P81924)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 33c
- Putative odorant receptor 59c
- Putative odorant receptor 85d
- Odorant receptor 46a, isoform B
- Putative odorant receptor 71a
- Odorant receptor 42a
Sequence:
MASLQFHGNVDADIRYDISLDPARESNLFRLLMGLQLANGTKPSPRLPKWWPKRLEMIGKVLPKAYCSMVIFTSLHLGVLFTKTTLDVLPTGELQAITDALTMTIIYFFTGYGTIYWCLRSRRLLAYMEHMNREYRHHSLAGVTFVSSHAAFRMSRNFTVVWIMSCLLGVISWGVSPLMLGIRMLPLQCWYPFDALGPGTYTAVYATQLFGQIMVGMTFGFGGSLFVTLSLLLLGQFDVLYCSLKNLDAHTKLLGGESVNGLSSLQEELLLGDSKRELNQYVLLQEHPTDLLRLSAGRKCPDQGNAFHNALVECIRLHRFILHCSQELENLFSPYCLVKSLQITFQLCLLVFVGVSGTREVLRIVNQLQYLGLTIFELLMFTYCGELLSRHSIRSGDAFWRGAWWKHAHFIRQDILIFLVNSRRAVHVTAGKFYVMDVNRLRSVITQAFSFLTLLQKLAAKKTESEL
Protein: Small COPII coat GTPase SAR1 (EC 3.6.5.-) (Q59S78)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-exchange factor SEC12
- Protein transport protein SEC23
- Protein transport protein SEC31
- Protein transport protein SEC24
- Protein transport protein SEC13
- Protein transport protein SEC23
- Protein transport protein SEC23
- SED5-binding protein 3
- Protein transport protein sec16
- Patatin-like phospholipase domain-containing protein CaO19.1504
Sequence:
MWIFDWFQDILSSLGLWNKHAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGSVRFTTFDLGGHQQARRLWKDYFPEVNGIVFLVDAADTERFAESKAELESLFRIEELSQVPFVILGNKIDVPTAVGEMELKNALGLYNTTGKDTGKLPEGTRPIEVFMVSVVMRSGYGEAFKWLSQYI
Protein: Probable nucleoporin C890.06 (Q9URX8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10759889}. Nucleus {ECO:0000269|PubMed:10759889}. Note=Nuclear rim.
Interaction partners:
- Nucleoporin nup189
- Nucleoporin nup186
- Nucleoporin nup107
- Nucleoporin seh1
- Nucleoporin nup44
- Protein transport protein sec13
- Nucleoporin nup85
- Nucleoporin nsp1
- Meiotically up-regulated gene 87 protein
- Nucleoporin nup184
Sequence:
MDINDPSFSSTENGIYELLSRGYAAIEAATERDLKLPELGDIIGQVHAPEYISQVLSGWKPFYLRSVVNIPDRIFEQYNRTECFTQMGLFAEIQRAWITVDNRLFLWDYLSGQNFQAYEDLSHTIVNVKLVRPKANVFVSEIQHLLVIATSQEMLLLGVTIDEKTGELSFFSTGIQISVQGINVNCIVSSEDGRIFFSGNKDPNLYEFSYQLEEGWFSRRCSKINITGSVFDNFIPSFFSFGTHGDGIKQIAVDDSRSLLYVLRETSSVSCYELTKNGVNRCVFYSFSSMISQAQMLNATSPLLDPRTTQIVSIVPIPAYESQQIYCVAITSTGCRFYMRGGRGPISHYAPSNSTLSSTPPSTLQLTFVRFPPPMQVENYASSRNYPANPFFLQNQSTSQQQPERSSAVKTTPMKCSSLSNIYTSDLFFAISSSNTNEGDVVCCTAPEVGRIANAWQSGTQPSLIESSMYVPIKGFVQDIKCIQNSRERNELVSQFNTPPPTFAILTNTGVYVVVHRRPIDVLASAIRMGPSLSSGIDGQVQLFFESVGRAEGCATCLGIVSGCLDQGDFSHAAANFSGSTTKLAQADLLDIVKKYYIEFGGKAFIDQSRYNNQYDSSSLEFVRLSGCHDGLASSISRIIRNVWKNHVIIAKKMQNKRIHYAPAFNATEILKIQSGLLYLSTFLENNKSFIEGLNSPNTLIGSSNVADEIAVQAEHRALSALLLVLQQIVEGISFLLFLNDTGVSDFHEIVSSTSIDIQKSCSNMTFGEFFTSKRGREVTKELVNSLVNRHLQSGGNIDMVSQLLRKKCGSFCSADDVLIFKAVESLKKAKDTVDIEERQSLIELSYTLFKKAAHVFTPEDLRLAVEEYKSLNAYTTAVNLALHVASARDDRNQALSYLVDGMPENDPRREPFESRTKCYSYIFEILDSLESQMSNDSSAIKVDVYDTIQRSKDELFHYCFYDWYSFKGLTDRLIEIDSPYIQSYLERNSTKDMKIADLLWQYYAKREQYYQASIVLYDLATTHLAFSLEQRIEYLTRAKGFGSCHVPNSLRHKMNKVMLSVLEQLDVASIQDDVLIAIRGDMRIPTSKREELSKQLDGEIIPLSDLFNNYADPLGYGEICLSIFQCADYRGINEILNCWESIIKTTHENAIISPVGSSPVEAVSSTLKNLTLRFSQSENVFPIEQIIDITERYAFDQQGEAVATGWVIDTFLGAGVSHELIFIVLNQLYDRREKPWQGKDRLFFLIKEVTHLLKLWHEVSVRAGVAQTSKPSFDAPLVLEAIEKYKNALGAPDTATKSCKENLISLDSEIRQTY
Protein: GH09754p (Q9VFR4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLASVAARLALFAVISTQSLQLLQAAPFPGIENAAFTSDDLLAEESSPVVSQVHVQHNRHRRHHEDGNYHGHRHHKRHWDHHFPGPDCHHPARFGFGFEHGGPPPQGHHHRFEPHDFQPFPNAFGPPEYEEHRRPFEAPLEPFEENKGGIKELTKQASSSSLAPPPAAPVTPSSRTSTTTTTTTSTTRSTTLAPTSSSTEEAPLAIDIRIG
Protein: Hexaprenyl-diphosphate synthase small subunit ((2E,6E)-farnesyl-diphosphate specific) (HexPS) (EC 2.5.1.83) (Hexaprenyl diphosphate synthase) (Hexaprenyl pyrophosphate synthetase) (O66127)
Organism: Micrococcus luteus (Micrococcus lysodeikticus)
Function: Catalyzes the condensation of three molecules of isopentenyl diphosphate with farnesyl diphosphate (FPP) to yield (all-E)-hexaprenyl diphosphate (HexPP; C30), the precursor of the prenyl side chain of menaquinone-6. Large subunit Hexs-B catalyzes the condensation reaction and the final product chain length is cooperatively regulated by both the Hexs-A and Hexs-B subunits using the whole size of the hydrophobic cleft as a ruler.
Interaction partners:
Sequence:
MRYLHKIELELNRLTSRYPFFKKIAFDAEIIKLVDDLNVDENVKCAIVAIDTSMRMQDFINEDNKDSFVLSTDVLSALFYKYLSQPFYQHDFLVLTDCVSRINELKSIRATITDEIALHNINKQIHYMFIQPYMNNEKVVSYE
Protein: Natural killer cell receptor Ly-49P2 (Natural killer cell receptor Ly49P2 isoform) (Q9EPC4)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTFSTVRFQKTSGLQNRVRLEETLKPRKAGLRVCSVPWQFIVIALGILISLRLVIVAVLVTNSRGDKVYWFCYGRKCYYFVMDRKPWSGCKQTCQSSGLSLLKIDDEDELKFLQLVVPSDVCWIGLSYDNKKKDWSWVDNGPSKLALNTRKYNIRDGGCMLLSKTRLDNGNCDQVFICICAKRLDKFPH
Protein: E3 ubiquitin-protein ligase Rnf220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase Rnf220) (Q6PDX6)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). Plays a critical role in the regulation of nuclear lamina.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20170641}. Nucleus {ECO:0000250|UniProtKB:Q5VTB9}.
Interaction partners:
- Zinc finger C4H2 domain-containing protein
Sequence:
MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFDSQAPLCPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASIKREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREGSCMAEDDAVDIEHADSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGEGSKQEAMQKTCKNSDIEKITEESAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL
Protein: RAN binding protein 3 (cDNA FLJ58549, highly similar to Ran-binding protein 3) (B7Z7F3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADLANEEKPAIAPPVFVFQKDKGQKRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSDDDDVLAPSGATAAGAGDEGDGQTTGST
Protein: Porin D (EC 3.4.21.-) (Imipenem/basic amino acid-specific outer membrane pore) (Outer membrane protein D2) (P32722)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Porin with a specificity for basic amino acids. Also possesses serine protease activity.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:2118530}; Multi-pass membrane protein {ECO:0000269|PubMed:2118530}.
Interaction partners:
- Outer membrane porin F
- Porin P
- Porin B
- Multidrug efflux outer membrane protein OprN
- Porin O
- Multidrug resistance protein MexB
- Multidrug resistance protein MexA
- Beta-lactamase
- Outer membrane protein OprJ
- DNA topoisomerase 4 subunit A
Sequence:
MKVMKWSAIALAVSAGSTQFAVADAFVSDQAEAKGFIEDSSLDLLLRNYYFNRDGKSGSGDRVDWTQGFLTTYESGFTQGTVGFGVDAFGYLGLKLDGTSDKTGTGNLPVMNDGKPRDDYSRAGGAVKVRISKTMLKWGEMQPTAPVFAAGGSRLFPQTATGFQLQSSEFEGLDLEAGHFTEGKEPTTVKSRGELYATYAGETAKSADFIGGRYAITDNLSASLYGAELEDIYRQYYLNSNYTIPLASDQSLGFDFNIYRTNDEGKAKAGDISNTTWSLAAAYTLDAHTFTLAYQKVHGDQPFDYIGFGRNGSGAGGDSIFLANSVQYSDFNGPGEKSWQARYDLNLASYGVPGLTFMVRYINGKDIDGTKMSDNNVGYKNYGYGEDGKHHETNLEAKYVVQSGPAKDLSFRIRQAWHRANADQGEGDQNEFRLIVDYPLSIL
Protein: Zgc:162883 protein (A4QP54)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MENFGLYVVTWNVATAEPPDDVNALLQLNSPKKPDLYVIGLQEVRAAPLKFVSDLAFEDSWSHLFMDTLSPLHYIKVSSIRMQGLLLLFFSKLEHVPFIRDIQVTYTRTGLYGYWGNKGGVTIRLSFYGHMLCFLNCHLTAHMNYASQRVDEFEHILDAQNFNTKNTPHVLDHKVVFWFGDLNFRIEDHGMLFVRNCITSQRFNLLWPKDQLTMMKQKEVILQKFEEGPLDFQPTYKFDLNSDNYDTSGKKRKPAWCDRILWRVNPKASLTENTNEEEPEKQQEEEREDEFPLKMTQEYYTSKMEYGISDHKPVIGIFRLELRKMYETPLVQVFAEGEWSADFDAVITYRLLQAFASSAWDWIGLYKVGFKSVSDYITYAWVKDDQVSFNEELFQVFMNKDEIPVLGGECVLCYYSSNLQCIVGISQPFKVQESRAAIEEGLVPENINGLNQALAS
Protein: SKP1-like protein 15 (AtSK15) (Q1PEL7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-1
- Cullin-like protein 3
- Cullin-2
- Putative cullin-like protein 1
- Putative cullin-like protein 2
- RING-box protein 1a
- RING-box protein 1b
- F-box protein 7
- Elongin-C
- Cullin-3A
Sequence:
MSSNKIVLTSSDGESFQVEEVVARKLQIVKHLLEDDCVINEIPLQNVTGNILSIVLEYCKKHVDDVVDDDASEEPKKKKPDDEAKQNLDAWDAEFMKNIDMETIFKLILAANYLNVEGLLGLTCQTVADYIKDKTPEEVRELFNIENDFTHEEEEEAIRKENAWAFEADTKHEDPKP
Protein: Small ribosomal subunit protein uS14 (40S ribosomal protein S29) (P62275)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62273}. Cytoplasm {ECO:0000250|UniProtKB:P62273}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAP6}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P62273, ECO:0000250|UniProtKB:Q6QAP6}.
Interaction partners:
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS8
- Ubiquitin-ribosomal protein eL40 fusion protein
- Small ribosomal subunit protein uS7
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS4
Sequence:
MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD
Protein: Valine amino-acid permease (Branched-chain amino-acid permease 3) (P41815)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC