Protein: DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase 2 a) (AtPOL2a) (DNA polymerase II subunit a) (Protein ABA OVERLY SENSITIVE a) (Protein EARLY IN SHORT DAYS 7) (Protein EMBRYO DEFECTIVE 142) (Protein EMBRYO DEFECTIVE 2284) (Protein EMBRYO DEFECTIVE 529) (Protein TILTED 1) (F4HW04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA polymerase II, which participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions. Involved in maintaining epigenetic states, controlling hypersensitive response (HR), and mediating abscisic acid (ABA) signaling. Required for flowering repression through a mechanism involving epigenetic gene silencing. May participate in processes involved in chromatin-mediated cellular memory.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon subunit B
- DNA polymerase II subunit B4
- DNA polymerase alpha subunit B
- DNA polymerase delta small subunit
- Probable DNA primase large subunit
- DNA primase
- Cell division cycle 45
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
Sequence:
MSGDNRRRDRKDTRWSKKPKVVNTAEDELESKLGFGLFSEGETRLGWLLTFSSSSWEDRDTGKVYSCVDLYFVTQDGFSFKTKYKFRPYFYAATKDKMELELEAYLRRRYERQVADIEIVEKEDLDLKNHLSGLQKKYLKISFDTVQQLMEVKRDLLHIVERNQAKFDALEAYESILAGKREQRPQDCLDSIVDLREYDVPYHVRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDIETTKLPLKFPDAEYDQIMMISYMVDGQGFLIINRECVGEDVEDLEYTPKPEFEGYFKVTNVKNEVELLQRWFYHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRAKFACHLDCFAWVKRDSYLPQGSHGLKAVTKAKLGYDPLEVNPEDMVRFAMEKPQTMASYSVSDAVATYYLYMTYVNPFIFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVVCPNKNQADPEKFYQNQLLESETYIGGHVECLESGVFRSDIPTSFKLDSSAYQQLIDNLGRDLEYAITVEGKMRMDSISNYDEVKDEIKEKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNRLQPPSIVTDEICTACDFNRPGKTCLRKLEWVWRGVTFMGKKSDYYHLKKQIESEFVDAGANIMSSKSFLDLPKVDQQSKLKERLKKYCQKAYKRVLDKPITEVREAGICMRENPFYVDTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNSIKIQEAQDMVVVYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCCLPGSFPENFTFKTIDMKKLTISYPCVMLNVDVAKNNTNDQYQTLVDPVRKTYKSHSECSIEFEVDGPYKAMIIPASKEEGILIKKRYAVFNHDGTLAELKGFEIKRRGELKLIKVFQAELFDKFLHGSTLEECYSAVAAVADRWLDLLDNQGKDIADSELLDYISESSTMSKSLADYGEQKSCAVTTAKRLAEFLGVTMVKDKGLRCQYIVACEPKGTPVSERAVPVAIFTTNPEVMKFHLRKWCKTSSDVGIRLIIDWSYYKQRLSSAIQKVITIPAAMQKVANPVPRVLHPDWLHKKVREKDDKFRQRKLVDMFSSANKDVVLDTDLPVTKDNVEDIEDFCKENRPSVKGPKPIARSYEVNKKQSECEQQESWDTEFHDISFQNIDKSVNYQGWLELKKRKWKVTLEKKKKRRLGDLRSSNQVDTHEINQKVGQGRGGVGSYFRRPEEALTSSHWQIIQLVPSPQSGQFFAWVVVEGLMLKIPLSIPRVFYINSKVPIDEYFQGKCVNKILPHGRPCYSLTEVKIQEDQFKKESKKRAALLADPGVEGIYETKVPLEFSAICQIGCVCKIDNKAKHRNTQDGWEVGELHMKTTTECHYLKRSIPLVYLYNSTSTGRAIYVLYCHVSKLMSAVVVDPFNGNELLPSALERQFRDSCLELSLDSLSWDGIRFQVHYVDHPEAAKKIIQRAISEYREENCGPTVAVIECPDFTFMKEGIKALDDFPCVRIPFNDDDNSYQPVSWQRPAAKIAMFRCAAAFQWLDRRITQSRYAHVPLGNFGLDWLTFTIDIFLSRALRDQQQVLWVSDNGVPDLGGINNEEAFFADEVQQTSLVFPGAYRKVSVELKIHNLAVNALLKSNLVNEMEGGGFMGFEQDVNPRGINSNDNTSFDETTGCAQAFRVLKQLIHSCLTDVRKSKNIYADSILQRLSWWLCSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIIDTVKFDLSAAKAYCESLLSTVRNSDIFEWILLEPVHYWHSLLFMDQYNYAGIRADDEISLDEVTIEPKWSVARHLPEYIERDFIIIIAKFIFDPWKFAIENKKGSSESLEAQMIEYLREQIGSTFINMLVKKVDDIMSHMKEINVSDASRVSGQAPKGDYSLEFIQVISAVLALDQNVQQDVLVMRKSLLKYIKVKECAAEAEFLDPGPSFILPNVACSNCDAYRDLDICRDPALLTEKEWSCADTQCGKIYDREQMESSLLEMVRQRERMYHMQDVVCIRCNQVKAAHLTEQCECSGSFRCKESGSEFSKRMEIFMDIAKRQKFRLLEEYISWIIYGPSY