wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear distribution protein nudE homolog 1 (Nuclear distribution protein nudE-like 1) (Q06568)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for nuclear migration to the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
Subcellular location: Nucleus {ECO:0000269|PubMed:15965467}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15965467}. Note=Also localizes to the plus ends of cytoplasmic microtubules, and this requires PAC1.
Interaction partners:
- Nuclear distribution protein PAC1
- Dynein heavy chain, cytoplasmic
- Nuclear migration protein JNM1
- Protein NIP100
- Nuclear migration protein NUM1
- Nuclear fusion protein BIK1
- Karyogamy protein KAR9
- WD repeat-containing protein PAC11
- Cytoplasmic dynein intermediate light chain DYN3
- Kinesin-like protein KIP3
Sequence:
MVPNLDLETAIQIISSLETQLSELEGATKEYENDLEQVISKLKSDLLESQQQNKCNKKQITDLEIQVDELENENIQLRNKIETLQLESDRRLERNVLLEHELLDTKEALQKLRVSKEEATSGETRRNTRSLPSQNKKMKLFKDTIKVSTTSSTLYLQNMAKTNNAARSHCNIPNTQITQSTVIATTSSV
Protein: Protein Rex (Rev homolog) (Rex-1) (p27Rex) (P0C205)
Organism: Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
Function: Rex escorts unspliced gag-pro-pol and singly spliced env mRNAs out of the nucleus of infected cells. These mRNAs carry a recognition sequence called Rex responsive element (RxRE or XRE) located at the 3' region of the long terminal repeat (LTR). This function is essential since most HTLV proteins are translated from unspliced or partially spliced pre-mRNAs that cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rex itself is translated from a fully spliced mRNA that probably readily exits the nucleus. Rex's nuclear localization signal (NLS) binds directly to KPNB1/importin beta-1 without previous binding to KPNA1/importin alpha-1. KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rex to the nucleus. In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rex from KPNB1 and allows Rex's binding to the RRE in viral pre-mRNAs. Rex multimerizes on the RRE via cooperative assembly. This multimerization is critical for its full biological activity, since it may shield the viral RNA from being spliced or down-regulated, and probably exposes Rex's nuclear export signal (NES) to the surface. Rex can then form a complex with XPO1/CRM1, RANBP3 and Ran-GTP, leading to nuclear export of the complex. Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rex/RRE/XPO1/RANBP3/RAN complex, so that Rex can return to the nucleus for a subsequent round of export (Probable).
Subcellular location: [Isoform Rex]: Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.; SUBCELLULAR LOCATION: [Isoform p21Rex]: Host cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MPKTRRRPRRSQRKRPPTPWPTSQGLDRVFFSDTQSTCLETVYKATGAPSLGDYVRPAYIVTPYWPPVQSIRSPGTPSMDALSAQLYSSLSLDSPPSPPREPLRPSRSLPRQSLIQPPTFHPPSSRPCANTPPSEMDTWNPPLGSTSQPCLFQTPDSGPKTCTPSGEAPLSACTSTSFPPPSPGPSCPT
Protein: Ear6 protein (Eosinophil-associated ribonuclease 6) (Eosinophil-associated, ribonuclease A family, member 6) (Q923L7)
Organism: Mus musculus (Mouse)
Interaction partners:
- Eosinophil cationic protein 1
Sequence:
MGPKLLESQLCLLLMLGLVLMLASCQKPTASQWFATQHITYKANLQCNVEMQAINMHRPRCKGLNTFLHTSFINVVGVCSNPSGLCSDKISQNCHNSSSRVPITVCNLTTPRRNYTQCRYQTKGSVEYYTVACEPRVAWDCPIYPVVPVHLDGTF
Protein: Potassium voltage-gated channel, putative (Q387P8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal subunit protein L31, putative
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L29
- 60S ribosomal protein L35A, putative
- 60S ribosomal protein L19, putative
- 30S Ribosomal protein S17, putative
- 60S ribosomal protein L5, putative
- Ribosomal protein
Sequence:
MRFINQAASDRAVINAGGRRFETLFSTLHRYPDTPFAQLFPLPGRGARQHRGREFFLDVTPHVFEYILGFLRTNQLNLPAENLQIRAEVVYSMNQWGLLEHAFPPEVIEDGEGCSTGGAVVKLPDVCVVQVCDHMQHDQGVKRHALTITYGADGFQLRSLIRRVRRDLERQLSSTYWQCYQTNERAAFFVTTKVANGTADLLTTSVTQQLVEHTESMGYSLASSYVTLSPDVVHTSVRMLIHNFTFRRSRRVEVEPGDGIALGEGSETIEAEPNIPTMHVGPRREPLNAAESIPPRNERAVNIWTVD
Protein: RuvB-like 1 (EC 3.6.4.12) (Pontin) (Q9DE26)
Organism: Xenopus laevis (African clawed frog)
Function: Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Dynein axonemal particle {ECO:0000269|PubMed:30561330}.
Interaction partners:
Sequence:
MKIEEVKSTTKTQRIATHSHVKGLGLDENGIAKQAAAGLVGQENAREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALALAIAQELGNKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIRETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIYESLQKERVEVGDVIYIEANSGAVKRQGRSDTYATEFDLEAEEYVPLPKGDVHQKKEVIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGQINKVVNKYIDQGIAELVPGVLFIDEVHMLDIECFTYLHRALESSLAPIVIFATNRGNCIIRGTEDVASPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEINELFYDAKSSAKILAEQQEKFMK
Protein: DUF2996 family protein (A8MR59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein MET1, chloroplastic
- Expressed protein
- At1g67860/T23K23_29
Sequence:
MATIAGGSFGVPSSRISITTPTLSSSSLLPPLTLQSGTRKDNLLRCALQESSTSAVATEKKNKEEGEESTVAVPAKKPKPAAKAAAVAKPLRQMMEEDVIPPLQAILESQDDISDIDLSFQDDKLEGFFLKKSIPYSFWAFFPTGNLTGEQKDFQFPHTGQVRAPWNHFLSTRGNQLRTTLCFGSRSVLLHKGSSPFGTNEVFVHL
Protein: Putative pentatricopeptide repeat-containing protein At3g11460, mitochondrial (Mitochondrial RNA editing factor 10) (Q9CAY1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in C-to-U editing of mitochondrial RNA. Required specifically for editing the mitochondrial NAD2 transcript.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15269332}.
Interaction partners:
- Multiple organellar RNA editing factor 8, chloroplastic/mitochondrial
- DnaJ and Myb-like DNA-binding domain-containing protein
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- Phosphoglycerate mutase family protein
- Multiple organellar RNA editing factor 9, chloroplastic
- Multiple organellar RNA editing factor 1, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Organelle RRM domain-containing protein 6
- Cytochrome c-type biogenesis CcmH-like mitochondrial protein
Sequence:
MIVVTSFVRNSAVAAVASTPWNVRLRELAYQSLFSESISLYRSMLRSGSSPDAFSFPFILKSCASLSLPVSGQQLHCHVTKGGCETEPFVLTALISMYCKCGLVADARKVFEENPQSSQLSVCYNALISGYTANSKVTDAAYMFRRMKETGVSVDSVTMLGLVPLCTVPEYLWLGRSLHGQCVKGGLDSEVAVLNSFITMYMKCGSVEAGRRLFDEMPVKGLITWNAVISGYSQNGLAYDVLELYEQMKSSGVCPDPFTLVSVLSSCAHLGAKKIGHEVGKLVESNGFVPNVFVSNASISMYARCGNLAKARAVFDIMPVKSLVSWTAMIGCYGMHGMGEIGLMLFDDMIKRGIRPDGAVFVMVLSACSHSGLTDKGLELFRAMKREYKLEPGPEHYSCLVDLLGRAGRLDEAMEFIESMPVEPDGAVWGALLGACKIHKNVDMAELAFAKVIEFEPNNIGYYVLMSNIYSDSKNQEGIWRIRVMMRERAFRKKPGYSYVEHKGRVHLFLAGDRSHEQTEEVHRMLDELETSVMELAGNMDCDRGEEVSSTTREHSERLAIAFGILNSIPGTEILVIKNLRVCEDCHVFLKQVSKIVDRQFVVRDASRFHYFKDGVCSCKDYW
Protein: Transaldolase (EC 2.2.1.2) (Q57X22)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transketolase
- Glucose-6-phosphate isomerase
- fructose-bisphosphatase
- Fructose-bisphosphate aldolase
- ATP-dependent 6-phosphofructokinase
- Triosephosphate isomerase
- 6-phosphogluconate dehydrogenase, decarboxylating
- deoxyribose-phosphate aldolase
- Pyruvate kinase
- Glyceraldehyde-3-phosphate dehydrogenase, putative
Sequence:
MNQLESLKKHTCVVIDTADFSLLKEFSAEDATTNPSLVLAGSQVPQHAHLVNSAVEFARSNVSRLRDGLLSSADDERAQLLELAVDKLTVSFGVEILKAIPGRVSSEVDARLSYDADKMVKKAQHIVQLYAEAGVPKERLYIKLASTWEGIRAAERLEREGINCNLTLLFSFDQAVACAQAGVALISPFVGRVLDWYKAKYPEQADTFIGAQDPGVIAVTKIYNYYKRHGYKTVVMGASFRNTGEVLELAGCDKLTISPKLLQELASTPGEVVRKLDPARLTQSIPKLSELTRPESLFERETNNMAVEKLEEGIRNFAKDTEKLEALIATLL
Protein: Ubiquitin-protein ligase E3A (EC 2.3.2.26) (HECT-type ubiquitin transferase E3A) (Oncogenic protein-associated protein E6-AP) (O08759)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation. Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC. Synergizes with WBP2 in enhancing PGR activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9182527}. Nucleus {ECO:0000269|PubMed:9182527}.
Interaction partners:
- Cellular tumor antigen p53
- Tuberin
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Catenin beta-1
- Hamartin
- 26S proteasome non-ATPase regulatory subunit 4
- Transcriptional repressor NF-X1
- Disks large homolog 1
- Disks large homolog 2
- Protein scribble homolog
Sequence:
MATACKRSPGESQSEDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGASNNSEIKMNKKEGKDFKDVIYLTEEKVYEIYEFCRESEDYSPLIRVIGRIFSSAEALVLSFRKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAMEEDSEASSSRMGDSSQGDNNVQKLGPDDVTVDIDAIRRVYSSLLANEKLETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIVMENSNLHSPEYLEMALPLFCKAMCKLPLEAQGKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGDERRNKKGPRVDPLETELGVKTLDCRKPLISFEEFINEPLNDVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML
Protein: Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2] (Q05996)
Organism: Homo sapiens (Human)
Function: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
Subcellular location: [Processed zona pellucida sperm-binding protein 2]: Zona pellucida {ECO:0000269|PubMed:29895852}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20239}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20239}.
Interaction partners:
- Zona pellucida sperm-binding protein 3
- Zona pellucida sperm-binding protein 4
- Zona pellucida sperm-binding protein 1
- Limb region 1 protein homolog
- Sonic hedgehog protein
- Acrosin
- Oviduct-specific glycoprotein
- Growth/differentiation factor 9
- Astacin-like metalloendopeptidase
- Plasminogen-like protein B
Sequence:
MACRQRGGSWSPSGWFNAGWSTYRSISLFFALVTSGNSIDVSQLVNPAFPGTVTCDEREITVEFPSSPGTKKWHASVVDPLGLDMPNCTYILDPEKLTLRATYDNCTRRVHGGHQMTIRVMNNSAALRHGAVMYQFFCPAMQVEETQGLSASTICQKDFMSFSLPRVFSGLADDSKGTKVQMGWSIEVGDGARAKTLTLPEAMKEGFSLLIDNHRMTFHVPFNATGVTHYVQGNSHLYMVSLKLTFISPGQKVIFSSQAICAPDPVTCNATHMTLTIPEFPGKLKSVSFENQNIDVSQLHDNGIDLEATNGMKLHFSKTLLKTKLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH
Protein: Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) (Q9UBY0)
Organism: Homo sapiens (Human)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:8772498}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium/hydrogen exchanger 9B2
- Chloride anion exchanger
Sequence:
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
Protein: Protein MSO1 (P53604)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in secretion. Component of the secretory vesicle docking complex.
Interaction partners:
- Protein SSO1
- Protein transport protein SEC9
- Protein transport protein SEC1
- Synaptobrevin homolog 1
- Synaptobrevin homolog 2
- Protein SSO2
- Syntaxin UFE1
- Sporulation-specific protein 20
- Integral membrane protein SED5
- Protein transport protein SEC22
Sequence:
MMSQVSHSQEGSGRFWNKFKSSTKSLSTSLAHLSIKAEKDGDTVNTTLVHKGLVKFYENQHPFQGFPGWLGEKEDLPNERKILDTQVKHDMKKQNSRHFSPSFSNRRKASSEDPMGTPSSNGNTPEYTPASKSFQDIYNNHTSSSSATPRRASSRPTRPSAGQEFRASLGRSKTSNSFNTSSTPTPPPDASSGVMAMKDRLKRRNNDYGF
Protein: At2g25570 (Binding protein) (Expressed protein) (Q9SLA6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein OS-9 homolog
- Derlin-1
- Derlin-2.2
- Derlin-2.1
Sequence:
MFRRLILRQAAAVAAESKIACHHTVHGFEQRRGLHSRNEKAMEYVAKGWSAIKEVERVIDYCELNDRRLIPLLRGAKENFELALEADNLNTHARYWLSKLHLKYHVPGACKAVGAALLVEAADMGNADAQYELGCRLRVENDHVQSDQQAFHYIENAVDQLHPGALYLLGIVYLTGDCVKQDVDSAIWCFHRASEKGHAGAAIAYGSLLLRGVQVPESLTKLNVVGVSPPKRARKNLENPEMNPLEMAKEQFQIAARAGCDLGLKWLQRVEQEEKLLMREQDNECAYV
Protein: Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] (P09531)
Organism: Gallus gallus (Chicken)
Function: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Subcellular location: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-1]: Secreted {ECO:0000250|UniProtKB:P01137}.
Interaction partners:
- TGF-beta receptor type-1
- TGF-beta receptor type-2
- Decorin
- Receptor protein serine/threonine kinase
- Uncharacterized protein.
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog 3
- Integrin alpha-V
- Fibromodulin
- Collagen alpha-1
Sequence:
MDPSPLLALLLLLGAARALSTCQRLDLEAAKKKRIEAVRGQILSKLRLTAPPPASETPPRPLPDDVRALYNSTQELLKQRARLRPPPDGPDEYWAKELRRIPMETTWDGPMEHWQPQSHSIFFVFNVSRVRAEVGGRALLHRAELRMLRQKAAADSAGTEQRLELYQGYGNASWRYLHGRSVRATADDEWLSFDVTDAVHQWLSGSELLGVFKLSVHCPCEMGPGHADEMRISIEGFEQQRGDMQSIAKKHRRVPYVLAMALPAERANELHSARRRRDLDTDYCFGPGTDEKNCCVRPLYIDFRKDLQWKWIHEPKGYMANFCMGPCPYIWSADTQYTKVLALYNQHNPGASAAPCCVPQTLDPLPIIYYVGRNVRVEQLSNMVVRACKCS
Protein: Protein TIFY 11d (OsTIFY11d) (Jasmonate ZIM domain-containing protein 12) (OsJAZ12) (OsJAZ1) (Q7XEZ1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Repressor of jasmonate (JA) responses (By similarity). May act on an initial response of JA-regulated gene expression toward drought tolerance as part of a BHLH148-TIFY11D/JAZ12-COI1A complex.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Transcription factor MYC2
- Transcription factor BHLH148
- Coronatine-insensitive protein homolog 1b
- Coronatine-insensitive protein homolog 1a
- Os10g0506950 protein
- Coronatine-insensitive protein homolog 2
- Protein TIFY 3
Sequence:
MAAAGSSSRFAVTCGLLSQYMRERQQPQPPVTVLEAVAEEEEEEDARTMQLFPPRAAAADGVATPSAGTAPLTIFYDGRMVVVDDVPVEKAAELMRLAGSACSPPQPAHAAALPEMPIARKASLQRFLQKRKHRITTTSEPYKKAAVASPAPEKSFAVAPVKDEPATWLGL
Protein: Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (P35227)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:21282530}.
Interaction partners:
- Polyhomeotic-like protein 1
- Polycomb complex protein BMI-1
- Chromobox protein homolog 2
- E3 ubiquitin-protein ligase RING2
- E3 ubiquitin-protein ligase RING1
- Polyhomeotic-like protein 2
- Chromobox protein homolog 8
- Chromobox protein homolog 7
- E3 SUMO-protein ligase CBX4
- Polycomb protein SCMH1
Sequence:
MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTASGATTAANGGSLNCLQTPSSTSRGRKMTVNGAPVPPLT
Protein: Integrin beta-1-binding protein 2 (Melusin) (Q9UKP3)
Organism: Homo sapiens (Human)
Function: May play a role during maturation and/or organization of muscles cells.
Interaction partners:
- Small muscular protein
- Integrin beta-1
- Heat shock protein HSP 90-alpha
- [Pyruvate dehydrogenase
- Heat shock protein HSP 90-beta
- Ras GTPase-activating-like protein IQGAP1
Sequence:
MSLLCRNKGCGQHFDPNTNLPDSCCHHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTMGPHCAEKLPEAPQPEGPATSSSLQEQKPLNVIPKSAETLRRERPKSELPLKLLPLNISQALEMALEQKELDQEPGAGLDSLIRTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWGKQLPASCRHDWHQTDSLVVVTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVINVEQSSVFLMPSRVEISLVKADPGSWAQLEHPDALAKKARAGVVLEMDEEESDDSDDDLSWTEEEEEEEAMGE
Protein: PMS1 homolog 1, mismatch repair system component (D3Z0R7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGATSIEVKLENYGFDKIEIRDNGEGIKAVDVPVMAVKYYTSKISSHEDLGNLTTYGFRGEALGSICNVAEVVVTTRTSADDFSTQYVLDGSG
Protein: DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11) (Q9Y2Y1)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular location: Nucleus {ECO:0000305|PubMed:33335104}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerase III subunit RPC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I and III subunit RPAC2
Sequence:
MLLFCPGCGNGLIVEEGQRCHRFACNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD
Protein: Uncharacterized protein (Q580M8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVRRRPAASKKQSVASSNVKPPVQRHSKKVPSAAAPWKASGRQNSDVMPQSGKRSGAAGAVGVQPSPVGKQQPRGNRLHILPTAPEVNLWRGMCRPAILVQSLANIGTLVEVDQLLPFMSGEPRFPFSALTEDRLLVAVQALVDATWLLQPTIYVENGLQGGRSLTQNNGVPVTLPPHQRWRLVRKLVELSEAAVPMKFSILLTHGGRTGTINSTASELLPTSPCALRRRLECLRRLQQMREFHLRLVPALRRVGTKGEVAKLLFGPSAGQIDFVEPMPEVSAMRQGEQDVVRNLLEKVNECVPCGESWGSPFVMPLRISSGAYILQKYDRAEALARLLHVAEFFGLPPFLRSIRVSDGRQRPFIPHLVAKEDDSHSIGRLPPSLYFSPSDLDPHHYDVSGSGQEQVVQEELMDLAGRHCCFGVLTGEADQVISLIRTSASIRQQMKNKKNAEIKVEEIEDVAVDDGAAAHSEVIGVDPLASHAAAIVKGWQKNINSGGRKEAYVHWLCNNRWNQLTSYYAIVLMVVLPHGCEVEEKEGATEERDITTFYYVAAVCELTRQ
Protein: Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) (P81133)
Organism: Homo sapiens (Human)
Function: Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator 2
- Aryl hydrocarbon receptor nuclear translocator
- Homeobox protein orthopedia
- Melanocortin receptor 4
- Melanin-concentrating hormone receptor 2
- Oxytocin-neurophysin 1
- Pro-opiomelanocortin
- POU domain, class 3, transcription factor 2
Sequence:
MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS