wanglab/gogpt-training-data huggingface dataset:
Protein: Probable serine/threonine-protein kinase DDB_G0288147 (EC 2.7.11.1) (Q54JC7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MQPNQLKRPSLNHRFEPYTLKHLTICKRCEKEIIGVSNSAQICYSCKNIYHTRCCKEIETKKLELICLGPPKKIKTVWKIALIPSLFKSLFSKSKVIVNYSQQLINEKTFTLEAIKIWVDVMRVDNDRYIQITKYYDIFDEEVFNYIINMIIEKDINLPMVNIEFPVDLHSSVQQNQYINDQAVSQEQKQQQQQLQQQLILQQQQQQQLQQQQLNESYDNSTINNLNYSNDISNAFSPRSVFSALELSSNAQVMNALELSVPFNEDDNNDDSTLSASTYNRRNSNKNKNSNKNNTSSSSSAPASASSSKHSNLNESFSSSTTAAAIVNNIDNSNNSNNLAALSPRSTASTTTTTTTTTTTTSPKSNNHHHHQHHHQNSKSRKPSTIIINKKKIKSPKNKSSKRYMLTEQYKWSTQMIGLQILYRILFNEKNMIHFLNDKFMAPLAVLYPILINRLKAISLGSDNNNNNNNNNNNNNNNSNNNNNNNNEDFKLLSINCKLLISILNRMLDFETLIPLFFTNKVIESIAKVNSDRESLRGKLSKDEFEVMDRVVLLLGKYFHLEPYHSLIERRPEWIDMIINYSVEHKVGILHHEITRNEVKINVEIYDSPLCTVYSGVYNGMDVAIKEFSQDGMGFDWVSFYKEITIVSASQHPKVIKCYGAHTKNTNKPFIVTELCSRGTISNALNQIRKTTGQPPAIPLIVHMAIDAAQSLEFIHSKNIIHRDVKGNNFLVNENWEVKLIDFGVSRFVEARLGYTIVGTPNYMACELFNGQPYHQPADVFSFGVVLWEMFTQDTPYKNLTRIEQALFVQSGGRPTIPPTVPTTIANLIESCWVQTPHLRPTFTEILKVFYSLLTPPPDNEHLVPVVTRLFNSSIIQLKILKYLDTNTLLNCGLASRQLRYNLYNGISMEKKTFSNFWIKLMNFSKSKFRYELLSPSERKNDSTGSSPIIMCIQPFSPNSQSKNNNNNKNHHSDDIIDDDDDDDDDKTYPSLVIPFSASSPTLNINSENKNNNNVNEDKTSDTSSNSNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNLRQNQFLGNDLNKSQDNNQLMDGSGGRRDRSRSKSRSRSASPSNNHLHDKSLMGLLSSSQTSEIGDNNTNNNSDNEVDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIDNNNNNKDNNNILSSENNNNTTVIEQQQQQQNVTNNNSNEPKNSNNEPKNSNITNNIVNPNVFTTTTTTTTTTRTTTTTVYDGTGTLNNLLFKINDGGIISSDSSNSLSDPESEEYSMPIKRSSSIRSPGPVSAISPLFKSLSPNLSPIVPNIINGYSFENTSACD
Protein: Calpain-C (Calcium-activated neutral proteinase homolog C) (CANP C) (Q9VXH6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known; does not seem to have protease activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12646209}.
Interaction partners:
Sequence:
MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAHGVFRFRLWWCGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHESFHINPQLLISVQDEQDLVIALNQHTAVEPKVIGFTMYTWDGEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIKSILSC
Protein: Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) (Q96A56)
Organism: Homo sapiens (Human)
Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Subcellular location: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Interaction partners:
- Homeodomain-interacting protein kinase 2
- Cellular tumor antigen p53
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Nuclear protein 1
Sequence:
MFQRLNKMFVGEVSSSSNQEPEFNEKEDDEWILVDFIDTCTGFSAEEEEEEEDISEESPTEHPSVFSCLPASLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEATRGTDELHSPSSPRVEAQNEMGQHIHCYVAALAAHTTFLEQPKSFRPSQWIKEHSERQPLNRNSLRRQNLTRDCHPRQVKHNGWVVHQPCPRQYNY
Protein: ENHANCER OF AG-4 protein 2 (Protein AERIAL ROSETTE 1) (Q9XER9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that functions as repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP. Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA. Functions in association with HUA1 and HEN4 in AG pre-mRNA processing. Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression. Acts as transcription regulator that controls anthocyanin accumulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:25070081}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 37
- KH domain-containing protein HEN4
- Inactive protein FRIGIDA
- Protein LEO1 homolog
- DExH-box ATP-dependent RNA helicase DExH10
- ARM repeat superfamily protein
- Flowering locus K homology domain
- Uncharacterized protein At5g66000
- FRIGIDA-like protein 1
- Protein kinase superfamily protein
Sequence:
MAPGRKRGASKAKAKGQLVLGDLVLAKVKGFPAWPAKISRPEDWDRAPDPKKYFVQFFGTEEIAFVAPPDIQAFTSEAKSKLLARCQGKTVKYFAQAVEQICTAFEGLQNHKSNALGDEDSLDATEPGLTKAEIVDGTDHIVIESERTDNFNFRVDPCFPKLDENNGEERKAEIRKLDSSSFLESKVKTTSPVSESLEHSSFDPKIKKEDFDKGTDGSACNEHFGNGQKKLANGKRIKKEAGGSDRKGEDTVHRDKSNNSHVPGGRTASGNSDSKKSKGLLTEKTSSKVSADKHENSPGIKVGVSGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDDGSDSTGTVSDIKREIVLGLGARGGNFQYDKEAVAYTKRQRQTMEHATSPSFSGSRDKSGKGHLEQKDRSSPVRNVKAPAAQSLKKRRAVCIYDEDDDEDPKTPLHGKPAIVPQAASVLTDGPKRANVCHSTSTKAKISAGSTESTEVRKFPLRKHCEDASRVLPSNAENSTNSLPVVKPINELPPKDVKQILQSPKMSPQLVLTNKHVAGQHKVVKSSVKVSGVVMAKKPQSDSCKEAVAGSDKISSSQSQPANQRHKSASVGERLTVVSKAASRLNDSGSRDMSEDLSAAMLDLNREKGSATFTSAKTPDSAASMKDLIAAAQAKRKLAHTQNSIFGNLNPSFLSISDTQGRSHSPFMVQNASASAAISMPLVVQGHHQQGSSPSNHGHQSLSRNQIETDDNEERRLSSGHKSVGGSLSCSTEAAISRDAFEGMLETLSRTRESIGRATRLAIDCAKYGLASEVVELLIRKLESESHFHRKVDLFFLVDSITQHSHSQKGIAGASYVPTVQAALPRLLGAAAPPGTGASDNRRKCLKVLKLWLERKVFPESLLRRYIDDIRASGDDATGGFSLRRPSRSERAVDDPIREMEGMLVDEYGSNATFQLPGFFSSHNFEDDEEDDDLPTSQKEKSTSAGERVSALDDLEIHDTSSDKCHRVLEDVDHELEMEDVSGQRKDVAPSSFCENKTKEQSLDVMEPVAEKSTEFNPLPEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQSLTTQLSIASHHQIPFQPGFPPPTYPLSHQTYPGSMQQDRSSIFTGDQIVQGPGNSSRGGLVEGAGKPEYFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHPYPFPPQRDDARRYRNEEPWRIPSSGHSAENQNGAWIHGRNSHPGLPRVTDSFFRPPPERPPSGTMNYQPSAASNLQAVPAIPGHTAPQMLPSRPDIPTVNCWRPA
Protein: T-cell surface glycoprotein CD1b (CD antigen CD1b) (P29016)
Organism: Homo sapiens (Human)
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}.
Interaction partners:
- Beta-2-microglobulin
- T-cell surface glycoprotein CD1e, membrane-associated
- CD83 antigen
- C-type lectin domain family 4 member K
- T-cell surface glycoprotein CD1a
- T-cell surface glycoprotein CD1c
- Macrosialin
- Interleukin-10
- T-cell surface glycoprotein CD4
- T-cell surface glycoprotein CD8 alpha chain
Sequence:
MLLLPFQLLAVLFPGGNSEHAFQGPTSFHVIQTSSFTNSTWAQTQGSGWLDDLQIHGWDSDSGTAIFLKPWSKGNFSDKEVAELEEIFRVYIFGFAREVQDFAGDFQMKYPFEIQGIAGCELHSGGAIVSFLRGALGGLDFLSVKNASCVPSPEGGSRAQKFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQLGDILPNANWTWYLRATLDVADGEAAGLSCRVKHSSLEGQDIILYWRNPTSIGSIVLAIIVPSLLLLLCLALWYMRRRSYQNIP
Protein: Latrophilin Cirl (A1Z7G7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88923, ECO:0000255}.
Interaction partners:
- Teneurin-m
- Teneurin-a
- Netrin receptor unc-5
- LD28763p
- G protein beta subunit 5
- FI06402p
- PDGF- and VEGF-related factor 2
- SUZ RNA-binding domain-containing
- Protein expanded
- Guanine nucleotide-binding protein subunit beta-1
Sequence:
MILSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLRSTGHASPTSSAGSTHLIFAHKQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQYAEALDPPLATGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYYNQGSVGGADGGPVYEEILSNRNSDVQHYEVGDFDVDEVYNNSVGTGVFNNMRAAVAAGGSRYGGGSLSGGSVSSRSQQQQLKKQQQQQSLAQQRSARRCTADDDDDEDEEEDEEATAAEQLHDSVCDEDEEEDESDLEDDAHGLPPQSDERMRRLMAMQDEDFKRRFQRQLRKHGAPLDYGALPPGAGPQPEHNGAVFGVSGGVGEGSLRGAFRQQQQQALNAKSPGGRLAVNELFGHGNSGPPLPPANQTPAQKRQQLQKLSPQSTTSSSSHTSHSNPNPHPHQLTHPHPHQHPPHHQQRHLSAMLDENNTVRCYLEPLAK
Protein: Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (Q9P7Y7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Probable prephenate dehydrogenase [NADP
- Probable delta-1-pyrroline-5-carboxylate dehydrogenase
- Probable proline dehydrogenase, mitochondrial
- Probable phosphoserine phosphatase
- Probable glutamate 5-kinase
- DNA-directed RNA polymerase II subunit rpb1
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- Putative aminopeptidase C13A11.05
- RNA polymerase II subunit A C-terminal domain phosphatase
- Uncharacterized protein C4G9.04c
Sequence:
MSGFCVLGCGTMGKALLTGIFDSIAENGNDVSDEIIIPNKFYACVKFPKEKEDVQKLFGDRVKVVMGAKENAEMAAISNVLLLSCKPQAAEDVLNSPKMKEALKGKLILSILAGKTISSLQSMLDESTRVIRIMPNTASRIRESMSVICPGPNATEEDIKFAEWVFNGIGRSMKLPEKLIDAATAVCGSGPAFVATMIEAMTDGGVMMGIPFPQAQELAAQTMVGTGRMVLQGQHPAMIRNDVSTPAGCTISGLLALEDGKIRSTIARGIEQATKTASGLGK
Protein: Putative guanine nucleotide-exchange factor SED4 (P25365)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=In the process of transport, SED4 itself may migrate to the Golgi apparatus and function in subsequent transport events.
Interaction partners:
- Protein SEY1
- Small COPII coat GTPase SAR1
- Guanine nucleotide-exchange factor SEC12
- Protein transport protein SEC23
- COPII coat assembly protein SEC16
- Protein transport protein SEC13
- Protein transport protein SEC31
- ER lumen protein-retaining receptor
- Protein RER1
Sequence:
MSGNSANYDVGYPIYGAKFINEGTLLVAGGGGQFNSSFPNKITALKVNFQKKKHIRRFREITLDSIDDAPTSLDCNNNLILVGCNELFNDSSMENVNHHLRKFVFEQEHLKFVASIDFNRTTDPSVFTKFVYINQRATVAAIASSEVPTVIRIIDPRNLTENYEIETGREVNDLHFAPNGILLSYITSNSLEVASVRDGNFVARKTDFDKNLVLSNIRFLNDNTLLVAASLSNSDGVSLLKLGVSSKGVKILKTASFMFDLNGITSMDVSPNKKFVALSSNDNLVAIVSVEKLKLVQLVPRVHESTITKVTFSPDSRYLASTSMGNTINVLKLSGTSSSILRNIWKFFLNFVLLVVLAGAIQLGYKHNVHGFIYKHAHDIYKSKFKENTTIDQGSSSYFTINDDYRGITESADIISATDVASDIETEFSSFDTSTMRTTTEDEQKFVWISSSADSQFTSADIPTSASSSSSSSSSSFYEESVTNEPIVSSPTSEITKPLASPTEPNIVEKPSLPLNSESIDLLSSSSNSITEYPEPTPDLEEKLSSLIVEQSESEITTDRESVSKLLSTESPSLSHMPSSSSSSLSLSSSLTTSPTTALSTSTATAVTTTQTNPTNDAANTSFLDNSKPASTREIYKTKIITEVITKIEYRNIPASDSNAEAEQYVTTSSSMLLTPTDTMVSSPVSEIDPIASELERMVETPTHSISIASEFDSVASNLIPNEEILSTSASQDSISSHPSTFSDSSITSGFQSIEVSTVTSSVLASESIPSISDSTFSKFHSISEPVSSAIVETATSSFSKTETKTSRVIAFSTEDSERSSALIDNSEYTSVLADNLEPTSVLADNSEPTSVLADSSEPTSVFTDAVQSPKTSVGQSSLSESTNIEGTSMASMIFSSSGASIGALSDIGKGTLSVESASSTVAQPMPGVTTTAPSFVSSPHKISASSIDASGFVQKEIMIEVQSSKDSSEAFGVRHKISENVNTPVSRMLTTEMQASGTVDVTEDVSLSSEVISALNVEITSLPNPVAPPQTIAAPLNNNSNTNIVNDDNAVAGTVNYAGLHDEL
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q7JPM7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRHADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDEVCV
Protein: T-box transcription factor T (Brachyury protein) (Protein T) (O15178)
Organism: Homo sapiens (Human)
Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.
Subcellular location: Nucleus {ECO:0000269|PubMed:22611028, ECO:0000269|PubMed:24253444}.
Interaction partners:
- Eomesodermin homolog
- Bone morphogenetic protein 4
- POU domain, class 5, transcription factor 1
- Forkhead box protein H1
- Homeobox protein notochord
- Zinc finger protein SNAI1
- Homeobox protein MIXL1
- T-box transcription factor TBX6
- Delta-like protein 1
- Centromere protein T
Sequence:
MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQPGYSQWGWLLPGTSTLCPPANPHPQFGGALSLPSTHSCDRYPTLRSHRSSPYPSPYAHRNNSPTYSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWSVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPLYEGAAAATDIVDSQYDAAAQGRLIASWTPVSPPSM
Protein: Brain acid soluble protein 1 homolog (23 kDa cortical cytoskeleton-associated protein) (CAP-23) (P23614)
Organism: Gallus gallus (Chicken)
Function: May play a specific role in the development of tissues.
Subcellular location: Cytoplasm, cytoskeleton. Note=Cortical cytoskeleton.
Interaction partners:
- Neuromodulin
- Myristoylated alanine-rich C-kinase substrate
Sequence:
MGGKLSKKKKGYSVNDEKAKDKDKKAEGAATEEEETPKEAEDAQQTTETTEVKENNKEEKVEKDAQVSANKTEEKEGEKEKTVTQEEAQKAEPEKSEAVVDAKVEPQKNNEQAPKQEEPAAASAPAASSEAPKTSEPSSDAKASQPSEATAPSKADDKSKEEGEAKKTEAPATPAAQETKSEVAPASDSKPSSSEAAPSSKETVAATAAPSSTAKASDPSAPPEEAKPSEAPATNSDQTIAVQD
Protein: Toll-like receptor 4 (Q7ZTG5)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MPSRAAPTALTLGVLLQLLLVLSLLAGCIPSPCLEVIPSTAFRCTGQNISGVPAEIPNTTLDLDLSFNSLKLLSSNYFSSVPELQFLDLSRCHIHTIEDNSFVDLYNLSTLILTANSLQHLGLAAFHGLTSLKKLVLVETSISSLSDLPIGHLNTLQELNLGHNNIASLKLPKYFANLTSLRHLSFSSNNITYISKGDLDALRETNRLNLTLVLSLNNIKYIQSGSFAKIHLGELILRSSFENLNAMHSSLQGLAGLQVNRLIVGEFTNILKITAFQNGLLSGLCQVQMQEFVLMCFREFENDTDTLFDCIGNVTTIRLVDLNLETLSEVPMFSQVKHLEWKRCKFQELPAEKLSLFKELRVLRITKSKDLNGFEQKFGSLTYLEVVDLSENRLSFLTCCSPKFPRSPNLKHLNLSFNSDISLTGEFANLRNLLYLDLQHTKLIHHGTYPVFLLLQKLIYLDISYTKTHVMSHLIFHGLNSLQVLKMAGNSFENNTLTNNFENVRRLRILDISSCKLVWVDQSTFNALSELKELIISNNKLLTFDPVTYKPLQALTALDFSNNQMSFLSDSALEILPDSLVLLDISHNLFECSCTHLNFLKWVKEKQDLLQNKHSMICHTPAYMKNMSLSNFDMSSCHPNPTTVACSVTVLLAAGVFLFLIYKYYFQLYYSLVLLSGCKHSAERGDIYDAFVIHSSKDQEWVMKELVEPLEEGKPPFQLCLYFRDFLPGVPIVTNIIQEGFLSSRNVIAVISADFLESKWCSFEFDIARSWQLVEGKAGIIMIILGEVDKTLLRQRLGLSRYLRRNTYLEWKNKEISRHIFWRQLTSVLLEGKKWNHEEIKLM
Protein: Actin-related protein 3 (Actin-2) (Actin-like protein 3) (Actin-like protein 66B) (P32392)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61158}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 3
- RE12101p
- WHAMM and JMY related, isoform B
- LD35927p
Sequence:
MAGRLPACVIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGDEAFDATGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYGPSICRHNPVFGTMT
Protein: Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) (cav-p60) (P85125)
Organism: Rattus norvegicus (Rat)
Function: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A.
Subcellular location: Membrane, caveola {ECO:0000269|PubMed:11512676, ECO:0000269|PubMed:11702238, ECO:0000269|PubMed:16236245, ECO:0000269|PubMed:18056712}. Cell membrane {ECO:0000269|PubMed:11512676, ECO:0000269|PubMed:11702238, ECO:0000269|PubMed:16236245, ECO:0000269|PubMed:18056712}. Microsome {ECO:0000269|PubMed:11512676, ECO:0000269|PubMed:16236245}. Endoplasmic reticulum {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:11702238}. Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus {ECO:0000269|PubMed:11702238, ECO:0000269|PubMed:16236245}. Note=Translocates to the cytoplasm from the caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712}.
Interaction partners:
- Caveolin-1
- Caveolin-3
- Caveolin-2
- EH domain-containing protein 2
- Dysferlin
- Tripartite motif-containing protein 72
- EH domain-containing protein 3
- Protein kinase C and casein kinase substrate in neurons 2 protein
- Caveolae-associated protein 3
Sequence:
MEDVTLHIVERPYSGYPDASSEGPEPTPGEARATEEPSGTGSDELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEEDAAAIELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGEVEVLKATEMVEVGPDDDEVGAERGAETDLLRGSSPDVHTLLEITEESDAVLVDKSDSD