wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/potassium-transporting ATPase subunit alpha (A0A060D9G1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
KQLFGGFCMLLWIGAVLCFMAHIIQVTSEEEPTNANLYLGLVLAVVVIITGCFSYYQEAKSSKIMDSFKNLVPQQALVVRDGEKKNINTEEVVVGDIVEVKGGDRIPADLRIISASGCKVDNSSLTGESEPQTRSPDFSNDNPLETRNIAFFSTNCVEGTARGIVINTGDHTIMGRIAALAMSLESGQTPLGIEIDHFIEIITGVSVFFGLTFLILSVILGYGWLPSIIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHDADTTENQSGTSFDKSSATWAALARVAGLCNRAVFLAEQNNVPILKRDVAGDASETALLKCIELCCGSVKDMREKYNKVVEIPFNSTNKYQLSIHENNMAGESNHLLVMKGAPERILDSCSTILLQGKEHPLDDEIKESFQKAYEELGGLGERVLGFSHFQLPDDQFPEGFDFDCEDVNFPTENLCFVGLMSMIDPPRAAVPDAVSKCRCAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEEIAARLKIPVSEVNPRDAKACVVHGGELKDMTAEELDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALRKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSITYTLSSKIPEMTPFLFLLLANIPLALGTVTILCIDLGTDMIPAISLAYEQAENDIMKRQPRNPKTDRLVNERLISVAYGQFGVMLAAAGFFTYFVIMAENGFYPMDLLGIRLDWENQYINDLEDSYGQQWTYESRKIIEFTCHTAYFAAVVIAQWAVLIVCKTRKNSFFQQGLMKNRVLIFGLCSESALALFL
Protein: Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) (Q9GZT9)
Organism: Homo sapiens (Human)
Function: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}. Nucleus {ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm (PubMed:19631610). Nuclear export requires functional XPO1. {ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Interaction partners:
- Endothelial PAS domain-containing protein 1
- Hypoxia-inducible factor 1-alpha
- von Hippel-Lindau disease tumor suppressor
- Protein OS-9
- Prolyl hydroxylase EGLN3
- Hypoxia-inducible factor 3-alpha
- Peptidyl-prolyl cis-trans isomerase FKBP8
- Aryl hydrocarbon receptor nuclear translocator
- Prolyl hydroxylase EGLN2
- Elongin-C
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
Protein: Rrp44p homologue (Q95Z12)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFTKKRLAVHQVRSSATRRTASGITRSDIGCGTVGCKLCASTACQNSGNSSSLVPTAPIMIPDAVTILHNMNAMEDARIQNIVLLSTVMSEVQERNKAIYARLQRLVGGERKQCYVFSNDRHEQTHCVMQSEETRSDFNDRCVRVAGRWYAQHLALAFPAVTGVAEIPSVVLVSHDKLLQSAPNSAQAEENISNLSCLTLRQFLAGCVTAGTDLLEMIQPDRPVEGKEQGSARALFSPHLAESALDLGVQNGTYLRGKLRVSETNCFFGEIRGQWKGHNFERVLLPGRTNLNRAIHGDIVTVELLPVASWRPLRGAKPTEEMNDTGAGGDDHENSGREGIGEESEGAALARGYTPVGRVVGITTMNRRPFCGSIDVEELNKLADTLDTLTGTVSVLFQPKDNRIPRIRITTAHLGDLKDKRLSVIIDDWGEHSSFPVGHYVEVLGTIGDKDTEAKVILLENDIPHYDFSEAVYDCLPKGEWNVTEEELGNRLDLRDLCVVSVDPLGCRDIDDALHCRRVNGNHLEVGVHIADVTHFLKEGTAMDEEAAKRSTSVYLVDRRINMLPQLLTENLCSIVADEDRYAFSIMWEFDENYSVVREFFGKTVIRSRAALYYGDAQRMIDDPEDESEAAVSLRYLMQLSRHFRKRREKDGALFLCSQEFKFKVDNDHVNPTDMQAYQTFDSNSMIEEWMLFANAAAARRVYASFPRWTLLRRHQAPAENAFDTLNEAIRRKIGVKLDDTTSLALNESLEKCVDPSDPYFNRLIRTLVTRCLRQAQYFSSSEVSKDEFHHFGLAMPIYTHFTSPIRRYADVIVHRQLAAALGIMDVSEAHMVSVKMEALASNLNYRHEQAQRAGRDSQNLFTGFYLRNFANQEIPSEDGYVVKLSETHVFVLVPKYGQEGKIAKETLVRVPNLLDKVKVGIEVRQRGDVLRASLVFSIIGLMKGCEDVSEPVAIAGEELPLKRQRLEEERQ
Protein: Variant surface glycoprotein (VSG), putative (Q38CP5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MKNRQGEHSPLRETLITKTLPMPYSTIPTLLLIFNAATTCTANKANDPAAEAATDVCKEHAYLTRLSQHIQGKLNDIKATIRLQKTEARKWRMAAAKAQEQGQKCLLTALELTISDALEANELELERVRKTVNSATTAIKQQQGVIAAALAVSAVHAKMNSGSVHSSTGGGSPYTATLKLVKAKSEDLCKLETDEAKETFGGETPEPQDLFKLDLTDKSKVNKANQLDGIKITAEGGCTTQNSQSATGALNACSFSGASGAVEITKAKPPASAYRTATHFFKSNEDKTACHSDITAADAANEPLKRRAKAICEGVKLTPNTTKISEYSGKSLSGSHAIRTYVRNCWPAFHNIDDPTDNSKAKELIKWIEKGYGETADNFNDKFKSLLEGESTPIRDKGEVESKKITELTSSTEKTNQAVSLMEGIRIKRELEAEKKNIPKAIDTKKPEECKGEKDETKCNNKDGCEYKDGECKVKATTAATGTDGKATNTTVSNSFVINKAPLLLAFLIL
Protein: Mitochondrial import inner membrane translocase subunit TIM23-1 (Q9LNQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of the TIM17:23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Links the inner and outer membranes (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM17-2
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM44-1
- Mitochondrial import inner membrane translocase subunit TIM17-3
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Mitochondrial import inner membrane translocase subunit TIM17-1
- Probable mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit PAM16 like 1
- Mitochondrial import inner membrane translocase subunit TIM14-3
- Mitochondrial import inner membrane translocase subunit TIM14-1
Sequence:
MAINRSSDHESDENTRLYHPYQNYQVPIKSQYLYKLPTSPEFLFTEESLKQRRSWGENLTFYTGTGYLAGSVAGASAGIFSGIKSFENGDTTKLKINRILNSSGQAGRTWGNRVGIVGLIYAGIESGVVAVTDKDDVWTSVVAGLGTGAVFRAARGVRSAAVAGAFGGIAAGAVVAGKQVFKRYAHI
Protein: Negative elongation factor complex member A (C9JHL4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEHPILQMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGREAKRRRKTL
Protein: Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver) (Cytochrome c oxidase subunit 8-2) (Q64445)
Organism: Mus musculus (Mouse)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10176}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10176}.
Interaction partners:
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 7A2, mitochondrial
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit NDUFA4
- Cytochrome c oxidase subunit 1
Sequence:
MSVLTPLLLRSLTGSARRLMVPRAQVHSKPAREQLGVLDITIGLTSCFVCCLLPAGWVLSHLESYKKRE
Protein: Water witch, isoform D (A0A0B4LGT2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKLEIENSSLSNWHHPWIWLQTVFKSIPPNLMVRWRNNTDAMIEAQYPTAGEFEYMECGPSPPAESAPSMYDSFEEPTSELSVQICNDTLRISLIDQMKSAAGRVKLFEDIEQSNVVAEGIRTHFESASKLEKNLCYLWAAYLKRWDLIESLLEAGADLHFCDQNGISALHLSAFSGCLATLGLLVAKGLNVNLQSKCYTPLHCAAFGNAAEAAKLLINNGADISKDTSKPNCEESLLHCAVRSNALECLQIFIAEGADVNSLKPNGTNAIHLAADLGNIQCLEALLNAPNADANVRICIREKESTALHLAADEGNVECVDLLLAKGADAKLKNHRGFTPLHLAARTSSLDCVESLLRNGNADANAEDFDHRTPLHAAVGKSENAYDIMETLIQWGANVNHKDIYGFTALHLAALDGLVQCVEMLIFHGADVTTKSKKGTSALNVITRKTPASVAMIRQKLDAAITLHHSQDPVNREVELELDFRQLLQHCHPREISYLNTFVDEGQKEILEHPLCSSFLYIKWGKIRKYYIGRLIFCFSFVLFLTLYVLTALAHNCYNGSKNDNTTIPAQELCQKQSILGDMLRNNPFVMEMQWWVLVAITIVEIFRKLYGITGYSSFRHYVTQVENIMEWFVITSVFVISYIYTNKTYTFQNHIGAFAVLLGWTNLMLMIGQLPVFDVYVAMYTRVQGEFAKLFMAYSCMLIGFTISFCVIFPSSSSFANPFMGFITVLVMMIGEQDLSLLINDPEGKDPPFLLEVSAQITFVLFLLFVTIILMNLLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGYLPTWLRNLLHYTALVSPQAYRVVLCVKPLNPSEKRLPREILMKAYEVGKMRKHFGHTISSKNSAENYLSYKNKYNNNNGATTGYVLPDSDPDAGQFTTLTTKIDDNADRIEFLTQEIQELKQALISQQQQASKVIDKLLIVISNQQKQNLRK
Protein: Intermediate filament protein ifa-1 (Cel IF A1) (Intermediate filament protein A1) (IF-A1) (P90901)
Organism: Caenorhabditis elegans
Function: Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11427699}.
Interaction partners:
- Intermediate filament protein ifc-2
- Intermediate filament protein ifa-2
- Intermediate filament protein ifb-1
- Intermediate filament protein ifp-1
- Intermediate filament protein ifd-1
- Intermediate filament protein ifc-1
- Intermediate filament protein ifb-2
- Uncharacterized protein
Sequence:
MMEITRETMSFTSTTPSARAPLGGRTTGNVTSQDRMLKIVTEMRSGAGSGLSPFGQNAASTIRDSREREKKEMSDLNDRLASYIEKVRFLEAQNRKLAADLDALRSKWGKDTHNIRNMYEGELVDAQKLIDETNKQRKDMEGQLKKMQDELAEMRRKLEDATKGREQDRAKIDALLVTLSNLEAEISLLKRRIAQLEDEVKRIKQENQRLLSELQRARTDLDQETLNRIDYQNQVQTLLEEIDFLRRVHDNEIKELQTLASRDTTPENREFFKNELSSAIRDIREEYDQVNNVHRNDMESWYRLKVQEIQTQSARQNMEQGYAKEEVKRLRTQLSDLRGKLADLESRNSLLEKQIQELNYQLEDDQRSYEAALNDRDSQIRKMREECQALMVELQMLLDTKQTLDAEIAIYRKMLEGEENRAGLKQLVEQVVKTHAITQETDTETMRVVKGETASRQSFQRSAKGNVSIHEASPDGKFIVLQNTHRAKDEAIGEWKLKRRIDGKRENVYTLPRDFVLRAGKTLKIFARNQGVASPPDQLVYDAEDSFGSGNNVQTILFNKEGEERATHIQRQSTA
Protein: Sodium-dependent phosphate transporter 1 (Phosphate transporter 1) (PiT-1) (RPHO-1) (Solute carrier family 20 member 1) (Q9JJP0)
Organism: Rattus norvegicus (Rat)
Function: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8WUM9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASTLAPITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSALLGAKVSETIRKGLIDVEKYNATQDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGIKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTIGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREVKSSPSESPLMEKKNNLKDHEETKMAPGDVENRNPVSEVVCATGPLRAVVEERTVSFKLGDLEEAPERERLPMDLKEETNIDGTINGAVQLPNGNLVQFSQTVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGDEMETLTWPNADTKKRIRMDSYTSYCNAVSDLHSESEMDMSVKAEMGLGDRKGSSGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYETRDVTTKEATPIWLLLYGGVGICMGLWVWGRRVIQTMGKDLTPITPSSGFSIELASAFTVVVASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAVFKHIILPV
Protein: Activating transcription factor 3 (Cyclic AMP-dependent transcription factor ATF-3) (Q7ZVX7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transcription factor Jun
- JunE proto-oncogene, AP-1 transcription factor subunit
- Transcription factor JunD
- Cellular tumor antigen p53
- Protein c-Fos
- JunB proto-oncogene, AP-1 transcription factor subunit a.
- DNA damage-inducible transcript 3 protein
- Cyclic AMP-dependent transcription factor ATF-4
- JunB proto-oncogene, AP-1 transcription factor subunit b.
- X-box-binding protein 1
Sequence:
MMLQHPGLGPSEISASALVPCLSPPGSLTLDDFTNFTPLVKEELRYAIQNKRMSNGMSTLTTDRACMNTERPTELPGMKREAVPEENDRRKRRRERNKIAAAKCRNKKKEKTDNLQKESEKLESINAELKAQIEELKNQKQQLVYMLNLHRPTCIVRAQNGQTPEDEKKLFIQQIKESTLQGLGFATNGPTHTAIPTSCGHL
Protein: LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (E7F187)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Acts as a positive regulator of hedgehog (Hh) signaling (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7Z3E5}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q7Z3E5}. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity). {ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
Interaction partners:
- Si:dkey-161j23.5.
- Glucose-induced degradation protein 8-A homolog
- Glucose-induced degradation protein 8-B homolog
- Centrosome and spindle pole-associated protein 1a.
- RNA pseudouridylate synthase domain-containing protein 1
- Tetratricopeptide repeat domain 23.
- Tubulin tyrosine ligase-like family, member 10.
Sequence:
MSFKKSLKMGENLASESDLLSMISEYLKFGEFEETARTFEKEVKRKGKPALKSAGASRRDSKIISIYEDFLSSFNDGDYKVFSELWAKNIPPEIRDFDPVAQKLEFYLQIHFTIYPLKSPLGSHDKAEFDSRITHFRHYLETRGAALSQTTEFLPFYALPFVPNPMVHPSFQELFQDSWMPDLRDRMEKFLTVTLKASNTPRLLALYNDAGKGNKEAIQQMQLQLTEAERKSAVHIRRFAKLQADHHNLIGVTAELVDSLEATVRGKMISPEYLQGVCVRLFSGNMRQSAAQSLDFTRPGTASSMLRASVAPQRPKDVPLLPSLDYEKLKKDLLTGSDRLKALLLQALRWRLTRSLHGEQRDTVLQAFISNDLLERYSNKQKTVLHLIKCKNEIVRQYTARLINAFASLCDGRLYLSQIPALLPFLLDCLKTEEKESVTRENVLAALQKLSLRRAQQSAMIRDGLIGWLVKELNDSDCLSDYTLEYAISLLMNLCLRTQGKKRCAEEAKYVLKVLTELLGHENHEIRYYVNGALYSILSVPEIREEAKQMSMEEILRCYNKEENPELNRQIEFIIKQLNSATIPEQEPESDDEEDEDDDDDEEDVMEADLDKEEVLQPQPKELSGESLLTTEYLGIMTNMMKTKRRSCPPSSRSIDEPLQRPVTPSSHKNTIAGGEGVYPVTRQRSEDSRFSSRPATRTGSRPSTAESIHQTLATDSDCWRSSVESGLMGSPERHVPAPGQTTNSVQSYSGHMVGFASRPKIPRTPDSDAGSAGRSRLPPLAPQFSNSEPQQSGSRPGSAGGSSGRPSQQSSQSNRK
Protein: CTTNBP2 N-terminal-like protein (Q9P2B4)
Organism: Homo sapiens (Human)
Function: Regulates lamellipodial actin dynamics in a CTTN-dependent manner.
Subcellular location: Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8SX68}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q99LJ0}.
Interaction partners:
- Striatin-interacting protein 1
- Striatin-3
- Striatin-4
- MOB-like protein phocein
- Programmed cell death protein 10
- Striatin
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Striatin-interacting protein 2
- Serine/threonine-protein kinase 24
- Serine/threonine-protein kinase 26
Sequence:
MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTRELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTASSSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQGPIKPVSPNSSPFGTDYRNLANTANPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLTKTHSQAASLTTAEDLASSCSSNTVVANGKDVELLLPTSS
Protein: Protein DEHYDRATION-INDUCED 19 (AtDi19-1) (Q39083)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:15937324, ECO:0000269|PubMed:16438971, ECO:0000269|PubMed:16786289}.
Interaction partners:
- Calcium-dependent protein kinase 11
- Cysteine proteinase inhibitor 2
- GPN-loop GTPase QQT1
- U11/U12 small nuclear ribonucleoprotein 31 kDa protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Toll-Interleukin-Resistance
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Pathogenesis-related protein 5
Sequence:
MDADSKRFLATLRSRSEMLMGFEEIDGDDDFQEEFACPFCAESYDIIGLCCHIDDEHTLESKNAVCPVCSLKVGVDIVAHITLHHGSLFKLQRKRKSRKSGTNSTLSLLRKELREGDLQRLLGFTSRNGSVASSVTPDPLLSSFISPTRSQSSPAPRQTKNVSEDKQIERKRQVFISPVSLKDREERRHKSEFVQRLLSSAIFDEV
Protein: G-protein coupled receptors family 1 profile domain-containing protein (Q86GT6)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MARAVNISPFASYTVVPITSAWPPDDLKADRVQLASFTTGKALLAIAILAMIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALIDLLFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIMMYIACVWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIWRAAKRLAAQDRLMSHCNSVDASERPRNGSAETKDFLNEKETIDVPKKERANSTNSRLFKLERKYLHRPSAFFSAAKGPLIRQTEKSECKARKTLGVIMSVFIICWLPFFILAIFKSFGMWIPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFREMLACRCATLQTVMRQQSFTSRYGPPV
Protein: Protein kish-A (Transmembrane protein 167) (Transmembrane protein 167A) (Q8TBQ9)
Organism: Homo sapiens (Human)
Function: Involved in the early part of the secretory pathway.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:19942856}; Single-pass type I membrane protein {ECO:0000269|PubMed:19942856}.
Interaction partners:
Sequence:
MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFWKCARIGERKSPYVAVCCIVMAFSILFIQ
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) (P48305)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 beta subcomplex subunit 3
Sequence:
MSFPKYEASRLSSLPTTLDPAEYDISSETRKAQAERLAIRSRLKREYQLQYYDPSRRGVIEDPALVRWTYARSANIYPNFRPNTKTSLLGALFGIGPLVFWYYVFKTDRDRKEKLIQEGKLDRTFNISY
Protein: At2g28790 (Pathogenesis-related thaumatin superfamily protein) (Putative thaumatin) (Thaumatin-like cytokinin binding protein) (Q9ZV34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAKTSLPLAASFLLLISFSSAVDTSRLFLTVVNNCPFTVWPAIQPNAGHPVLEKGGFALPTFTHRSFNVPTTHWSGRIWARTWCAHYNGKFSCLTGDCGNRLECNGLGGAPPASLAQFDLHHGGHHDFSSYGVSLVDGYNVPMTVTPHEGHGVCPVVGCREDLIKTCPAHLQVRSHSGHVVACKSGCEAFHTDELCCRGHYNSPNTCKASSHSLFFKHACPSSFTFAHDSPSLMHDCASPRELKVIFCH
Protein: Transmembrane protein 43 (Protein LUMA) (Q9DBS1)
Organism: Mus musculus (Mouse)
Function: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BTV4}. Nucleus inner membrane {ECO:0000269|PubMed:18230648}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q9BTV4}. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen. {ECO:0000269|PubMed:18230648}.
Interaction partners:
- Prelamin-A/C
- Plakophilin-2
- Emerin
- Desmoglein-2
- Endonuclease domain-containing 1 protein
- Junction plakoglobin
- Desmocollin-2
- SUN domain-containing protein 2
Sequence:
MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE