wanglab/gogpt-training-data huggingface dataset:
Protein: Gag-Pro polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein-dUTPase (NC-dUTPase) (EC 3.6.1.23); Protease (EC 3.4.23.-)] (P10271)
Organism: Mouse mammary tumor virus (strain BR6) (MMTV)
Function: Matrix protein.
Subcellular location: [Matrix protein p10]: Virion {ECO:0000269|PubMed:205999}.; SUBCELLULAR LOCATION: [Capsid protein p27]: Virion {ECO:0000269|PubMed:205999}.; SUBCELLULAR LOCATION: [Nucleocapsid protein-dUTPase]: Virion {ECO:0000269|PubMed:205999}.
Interaction partners:
Sequence:
MGVSGSKGQKLFVSVLQRLLSERGLHVKESSAIEFYQFLIKVSPWFPEEGGLNLQDWKRVGREMKRYAAEHGTDSIPKQAYPIWLQLREILTEQSDLVLLSAEAKSVTEEELEEGLTGLLSTSSQEKTYGTRGTAYAEIDTEVDKLSEHIYDEPYEEKEKADKNEEKDHVRKIKKVVQRKENSEGKRKEKDSKAFLATDWNDDDLSPEDWDDLEEQAAHYHDDDELILPVKRKVVKKKPQALRRKPLPPVGFAGAMAEAREKGDLTFTFPVVFMGESDEDDTPVWEPLPLKTLKELQSAVRTMGPSAPYTLQVVDMVASQWLTPSDWHQTARATLSPGDYVLWRTEYEEKSKEMVQKAAGKRKGKVSLDMLLGTGQFLSPSSQIKLSKDVLKDVTTNAVLAWRAIPPPGVKKTVLAGLKQGNEESYETFISRLEEAVYRMMPRGEGSDILIKQLAWENANSLCQDLIRPIRKTGTIQDYIRACLDASPAVVQGMAYAAAMRGQKYSTFVKQTYGGGKGGQGAEGPVCFSCGKTGHIRKDCKDEKGSKRAPPGLCPRCKKGYHWKSECKSKFDKDGNPLPPLETNAENSKNLVKGQSPSPAQKGDGVKGSGLNPEAPPFTIHDLPRGTPGSAGLDLSSQKDLILSLEDGVSLVPTLVKGTLPEGTTGLIIGRSSNYKKGLEVLPGVIDSDFQGEIKVMVKAAKNAVIIHKGERIAQLLLLPYLKLPNPVIKEERGSEGFGSTSHVHWVQEISDSRPMLHIYLNGRRFLGLLDTGADKTCIAGRDWPANWPIHQTESSLQGLGMACGVARSSQPLRWQHEDKSGIIHPFVIPTLPFTLWGRDIMKDIKVRLMTDSPDDSQDL
Protein: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative (EC 2.7.1.148) (Q8I470)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast
- indole-3-glycerol-phosphate synthase
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Sequence:
MNQFLNLKCVLFYFFCTHLFFLHVITKHNLKKEKGYIIRNDYKCKRKRKNNNLKKRSFFIICKNCRPNNNKFYIINNKGGENIYNVKKKKACGYVRLNNEANVEKNNVVNTNKEIEKLLLDVLDNRNNWYDSKYFSPAKINLFLRLKEKKETYNEVSTLMHSLNLGDDIFIRALKKEDQNKLRHFLHPCESGDFLTIVRMEDKNRDKETLKEDCKIDVINKSDKDLFKHMKEDIIIQEHEKLPYEYNDYPINNDNIIIKVLKRYREEFNISDDIRFLIHVNKRIPIFSGVGGGSSNGATVFYFLENIFYKYFKGDNIKANEFLKTIGSDISFFSSSGFAYCTDKGNNVTDLKNIEANIKDKDIYLFKIDEGLSSKLVYKNVDYKRIIQYNPVNLLKCLINTSNDDIIKQIEEKEKKFANTFISLDNRDNLQNVFVNDLEHSAFYLIKKLQDLKEYLRSQNMFDVVSMSGSGSSLFALSNKKTQTHEISSSFQNERIKKLISDIKIKFNMNVRVYLCDALRKGLDVWYDPIKLAHEFK
Protein: RNA-binding protein Nova-2 (A0A1W2P872)
Organism: Mus musculus (Mouse)
Function: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions.
Subcellular location: Nucleus {ECO:0000269|PubMed:30638744}.
Interaction partners:
- Polypyrimidine tract-binding protein 2
- Polypyrimidine tract-binding protein 1
- RNA binding protein fox-1 homolog 1
- RNA binding protein fox-1 homolog 2
- Serine/arginine repetitive matrix protein 4
Sequence:
MEPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVHSFIAEKVREIPQAMTKPEVVNILQPQTTMNPDRAKQAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTALNTLASYGYNTNSLSLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGDAGAGPGAGAAPPPPPPPGALGSFALAAAANGYLGAGAGGAAGAGGAPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGSPAATQAAQYLISQRVTYEQGVRASNPQKVG
Protein: NXPE family member 1 (Protein FAM55A) (Q8N323)
Organism: Homo sapiens (Human)
Subcellular location: Secreted.
Interaction partners:
- NXPE family member 4
Sequence:
MSSNTMLQKTLLILISFSVVTWMIFIISQNFTKLWSALNLSISVHYWNNSAKSLFPKTSLIPLKPLTETELRIKEIIEKLDQQIPPRPFTHVNTTTSATHSTATILNPRDTYCRGDQLDILLEVRDHLGQRKQYGGDFLRARMSSPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARNQGYDKIIFKGKFVNGTSHVFTECGLTLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREVSYLTDKENSLFHRSKVGVEMMKDRKHIDVTNCNKREKIEETCQVGMKPPVPGGYTLQGKWITTFCNQVQLDTIKINGCLKGKLIYLLGDSTLRQWIYYFPKVVKTLKFFDLHETGIFKKHLLLDAERHTQIQWKKHSYPFVTFQLYSLIDHDYIPREIDRLSGDKNTAIVITFGQHFRPFPIDIFIRRAIGVQKAIERLFLRSPATKVIIKTENIREMHIETERFGDFHGYIHYLIMKDIFKDLNVGIIDAWDMTIAYGTDTIHPPDHVIGNQINMFLNYIC
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (A8MTF4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPLPWDYPEAPWRRLHSSPPRPCPRALQGGGRRGPNPDPRGSKGLKQTVGALNPNLHLWGICSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS
Protein: WD repeat-containing protein GTS1 (Protein GIGANTUS 1) (Q944S2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the control of plant growth development. Acts as negative regulator of seed germination, cell division in meristematic regions, plant growth and overall biomass accumulation. May function by regulating ribosome activities and biogenesis in plant cells.
Interaction partners:
- TRAF-like family protein
- REF/SRPP-like protein At2g47780
- Short integuments 2, mitochondrial
- Large ribosomal subunit protein eL19z
- Guanine nucleotide-binding protein subunit beta
- Telomere repeat-binding protein 1
- Ribosome biogenesis protein WDR12 homolog
Sequence:
MEEVSSEMEVEVQNRQLSDSSPAQNVKKFGLKNSIQTNFGSDYVFQIVPKIDWTAIAVSLSTNTVKLYSPVTGQYYGECKGHSDTVNQIAFSSDSAASPHVLHSCSSDGTIRSWDTRSFQQVSRIDTGNDQEIFSFSYGGAADNLLAGGCKEQVLLWDWRNSKQVACLEESHMDDVTQVHFVPNKPNKLLSASVDGLICLFNTEGDINDDDHLESVINVGTSIGKIGFLGDGYKKLWCLTHIETLSIWNWEDGSCEVNLEKARELASDSWTQDNVDYFVDCHCPGGEDLWVIGGTCAGTVGYFPVNYKQPGSIGTAEAILGGGHIDVVRSVLQMPGEYGGAAGLFGWTGGEDGRLCCWKSDEDATEINRSWTSSELVVKPPRNRKKNRHSPY
Protein: Seripauperin-6 (P0CE90)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSTRLKPAISKALSKDGIYTIAN
Protein: Probable microtubule-binding protein TANGLED (AtTAN) (Q84M91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Is required for spatial control cell division during plant development. Through an association with microtubules, acts both for the positioning of cytoskeletal arrays that establish planes of cell division during prophase and for spatial guidance of expanding phragmoplasts toward preestablished cortical division sites (CDS) during cytokinesis (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000250}. Note=Preferentially localized to the preprophase band (PPB) during early stage of mitotis and later localized to the cortical division sites (CDS) during cytokinesis. {ECO:0000250}.
Interaction partners:
- Kinesin-like protein KIN-12C
- ATP-dependent DNA helicase 2 subunit KU80
- DNA ligase 6
- DNA ligase 4
- Cyclin-J18
- Kinesin-like protein KIN-12D
- Kinesin-like protein KIN-7A
- Cyclin-A2-2
- Cyclin-A2-1
- Cyclin-dependent kinase B2-2
Sequence:
MVARTPQKQRKVAMVVPPLNSDLLKETINKVDKCMERLQELQYTIAGGTKVVSGVNLSPRSTRIYLKTSLRCKQETLRIKNATNKKSPVGKFPASSPGDWRKMSLPAMLLGETVNEILQASQVTRDIVDAIAPKKSRKSRRLTMSQEDDGPKTPETQQKSREQNPETVSSNIKARRKKEKQNRRSESDSPPSLQRARSRIAFRTISPQVKGNNGENSFRHLANRVSPKHKPWVKKAVLFPNPLFISGTATQQAKFSRTMSPVIARNEISSIKNNKETPYKFLIKSPPTSASKFQVKIRSPPKVLVSPTRNGSNSVRKSPRGSRSPTRTVNLGKKSASISPIRNTGKRSPKLSTAAKLRRSFTPTRNGSNLARKSSISPKRVTLQAFLSPTRNGNFCKKSPKASISPTRVCNKSQKLSTAAKFRRSFSPSRLAMRFVSPMKSRKV
Protein: Methionyl-tRNA formyltransferase (EC 2.1.2.9) (O85732)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Interaction partners:
- Ribosomal RNA small subunit methyltransferase B
- Bifunctional protein FolD
- Peptide deformylase
- Methionine--tRNA ligase
- Dihydrofolate reductase
- Serine hydroxymethyltransferase 3
- Phosphoribosylglycinamide formyltransferase
- Methionine synthase
- Aminomethyltransferase
- aminomethyltransferase
Sequence:
MSQALRIVFAGTPEFAAEHLKALLDTPHRIVAVYTQPDRPAGRGQKLMPSAVKSLALEHGLPVMQPQSLRNAEAQAELAALRADLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMQMEAGLDTGPMLLKVSTPISAADTGGSLHDRLAALGPKAVIEAIAGLAAGTLHGEIQDDALATYAHKLNKDEARLDWSRPAVELERQVRAFTPWPVCHTSLADAPLKVLGASLGQGSGAPGTILEASRDGLLVACGEGALRLTRLQLPGGKPLAFADLYNSRREQFAAGQVLGQ
Protein: LAS seventeen-binding protein 3 (LAS17-binding protein 3) (P43603)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Actin cytoskeleton-regulatory complex protein SLA1
- Proline-rich protein LAS17
- Protein YSC84
- Mevalonate kinase
- Ubiquitin-binding protein CUE5
- Protein BZZ1
- F-actin capping regulator BSP1
- Myosin tail region-interacting protein MTI1
- Protein GTS1
- LAS seventeen-binding protein 5
Sequence:
MGINNPIPRSLKSETKKAAKILASFVKPNQVFGADQVIPPDVLKRAKGLAIITILKAGFLFSGRAGSGVIVARLKDGTWSAPSAIAMAGAGAGGMVGIELTDFVFILNTQDAVKSFSEFGTITLGGNVSVSAGPLGRSAEAAASASAGGVAAVFAYSKSKGLFAGVSVEGSAIIERREANRKFYGDNCTAKMILSGRIRPPPAVDPLFRVLESRAFNYRPSNGGRGSFDDDEDDYYDDDDYYNDIPSSFSSTDASSTRPNTRSTRRRAQSGSRYTFDDDDDDDDYGTGYSRNSRLAPTNSGGSGGKLDDPSGASSYYASHRRSGTAQSRARSSRNRWADDEYDDYDDDYESGYRRGNGRDRTKDREVDDLSNRFSKSRISSASTPQTSQGRFTAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV
Protein: Kinesin-like protein (Q385V1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Kinesin-like protein, putative
- Kinesin-like protein
- Kinesin, putative
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
Sequence:
MTSLCPITSSITVAIRKRPIANNGNSGDKDIVTCEDCRTISVHEPKTRVDLKAVVETSAFAFDYVFDESVANDVVYKVCCQPLLSDVQNGGSVVVIAFGQTGSGKTHTMLGHGSKTIGLYGYAIRELIGEETTRKLAVSFYEVYGSKLFDLLNGRTQLKMMQDEADNLRIVGLSEKVVTCDKEVYKLISKGESLRSSGSTLANDTSSRSHAVLEIKVLNYQGEPHGGRVTLIDLAGSERAADTTSSDTRGRHEGAEINKSLLALKECIRAMSRNRRHIPFRASKLTQVLRESFIGNCKTCFIATVSPLQRHCEDTLNTLRYANRIRDLKAPSDDGFSRKISMTCPNCNGPVRPDASHTCVRLSTRCPHCRQVVEKHNLEGHIEECSEFPVRCPRCNELLVRGDIPRHNRRCSRSLVRCPLCTCHVMRCGLEKHTLMDCGAKLEKCRYCGQGFPRHSLKRHEDVCTMMKIACPYCLQYFRKVCVDAHASVCVRNPNCRRVSPSRIRDSGEEVWKITNGKEWRQRPRMLRNQSLKQLEAISRTKSSVQLREGRKPLGPLEDNFSLPALHAPSSAPDRKHPPVTSAFTESLQSHPNSEDDDADKEVCRTAPTISGENSSRVGGEGCVCPYAAYGCLHTVCDSSLEKHMKDSVEMHLQLVRDYAERVSEENNILRERVNEGTTKASKLHELESV
Protein: Beta-amyrin synthase (BgbAS) (EC 5.4.99.39) (A8CDT2)
Organism: Bruguiera gymnorhiza (Burma mangrove) (Rhizophora gymnorhiza)
Function: Oxidosqualene cyclase involved in the biosynthesis of beta-amyrin.
Interaction partners:
Sequence:
MWRIKIAEGGKDPYLYSTNNYVGRQTWEFDPDAGTPEERAEVEEARQNFYKNRYQVKPCGDLLWRLQFLGEKNFEQTIPQVRIEEGEGITYEKATRALRRTVQFFSALQASDGHWPAEIAGPLFFLPPLVMCVYITGHLDAVFPAEHRKEILRYIYYHQNEDGGWGLHIEGHSTMFCTALNYICMRIIGEGPNGGQDDACARARKWIHDHGSVTNIPSWGKTWLSILGVYDWSGSNPMPPEFWMLPSFLPMHPAKMWCYCRMVYMPMSYLYGKRFVGPITPLIQQLREELFTQPYDQINWKKTRHQCAPEDLYYPHPFVQDLIWDCLYIFTEPLLTRWPLNEIIRKKALEVTMKHIHYEDESSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLARIPDYIWVAEDGMKMQSFGSQEWDTGFAIQALLATNLTDEIGDVLRRGHDFIKKSQVRDNPSGDFKSMYRHISKGSWTFSDQDHGWQVSDCTAEGLKCCLLFSMMPPEIVGEHMVPERLYDSVNVLLSLQSKNGGLSAWEPAGAQEWLELLNPTEFFADIVIEHEYVECTSSAIHALVLFKKLYPGHRKKEIDNFIVNAVRYLESIQTSDGGWYGNWGVCFTYGTWFALGGLAAAGKTYNNCLAMRKAVDFLLRIQRDNGGWGESYLSCPEKRYVPLEGNRSNLVHTAWALMALIHAGQMDRDPTPLHRAARLMINSQLEDGDFPQQEITGVFMKNCMLHYAAYRNIYPLWALAEYRRRVPLPS
Protein: Histone H1.5 (H1 VAR.5) (H1b) (P43276)
Organism: Mus musculus (Mouse)
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P16401}. Chromosome {ECO:0000250|UniProtKB:P16401}. Note=Mainly localizes with heterochromatin (By similarity). Associates with actively transcribed chromatin and not heterochromatin (By similarity). {ECO:0000250|UniProtKB:P16401}.
Interaction partners:
- Homeobox protein MSX-1
- Histone H3.2
- Testis-specific H1 histone
- Histone H1.8
Sequence:
MSETAPAETAAPAPVEKSPAKKKTTKKAGAAKRKATGPPVSELITKAVSASKERGGVSLPALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKTGAAKAKKPAGATPKKPKKTAGAKKTVKKTPKKAKKPAAAGVKKVAKSPKKAKAAAKPKKAAKSPAKPKAVKSKASKPKVTKPKTAKPKAAKAKKAVSKKK
Protein: C2H2-type domain-containing protein (CES-1) (G5ECN8)
Organism: Caenorhabditis elegans
Interaction partners:
- USP domain-containing protein
Sequence:
MITTPNISLTPTVAPPVDFPIIGNCDFQAQLWHLMSLHLQMQKSSAASTSSSSSSSTSSENLKKSPSSVQNTSVFSIDNILNSQKVPKLELENDEDVSSSPSPTCSTTGYTLDSLQNLDRRSLNKKGPSSHNRCVCDKCGKSYATTSNLSRHKQTHRALDSPHAKQCPHCDRVYVSMPALSMHILTHNASHECNVCGKRFSRLWLLQGHLRSHTGLRPFSCAHCGKSFADRSNLRAHMLTHTGDKRFECDKCGRRFALRAYLNRHLETCK
Protein: tRNA-specific adenosine deaminase TAD2 (AtTAD2) (EC 3.5.4.33) (Protein EMBRYO DEFECTIVE 2191) (tRNA-specific adenosine-34 deaminase TAD2) (Q6IDB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA editing. Catalyzes the specific deamination of adenosine-34 in several cytosolic tRNA species. Generates inosine at the wobble position of the anticodon loop.
Subcellular location: Nucleus {ECO:0000269|PubMed:25315605}. Cytoplasm {ECO:0000269|PubMed:25315605}. Note=Localizes predominantly to the nucleus. {ECO:0000269|PubMed:25315605}.
Interaction partners:
- tRNA-specific adenosine deaminase TAD3
- Guanosine deaminase
- tRNA-specific adenosine deaminase TAD1
- tRNA
- tRNA
- tRNA
- Putative tRNA
- Flavin mononucleotide hydrolase 1, chloroplatic
- tRNA
- tRNA
Sequence:
MEEDHCEDSHNYMGFALHQAKLALEALEVPVGCVFLEDGKVIASGRNRTNETRNATRHAEMEAIDQLVGQWQKDGLSPSQVAEKFSKCVLYVTCEPCIMCASALSFLGIKEVYYGCPNDKFGGCGSILSLHLGSEEAQRGKGYKCRGGIMAEEAVSLFKCFYEQGNPNAPKPHRPVVQRERT
Protein: CDK5 regulatory subunit associated protein 2 (Q5JTU8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
NMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Protein: UPF0434 protein YcaR (P0AAZ7)
Organism: Escherichia coli (strain K12)
Interaction partners:
- 3-deoxy-manno-octulosonate cytidylyltransferase
Sequence:
MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS
Protein: Translation initiation factor IF3-1, mitochondrial (AtIF3-1) (AtINFC-1) (Q6NLP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25630975}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- RING/FYVE/PHD zinc finger superfamily protein
- Small ribosomal subunit protein uS13c
- Small ribosomal subunit protein uS13m
- Small ribosomal subunit protein uS13z/uS13y/uS13x
- Eukaryotic translation initiation factor 4C
- Translation initiation factor IF-1
- Eukaryotic translation initiation factor 4C
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS7z
Sequence:
MAIWRIINRSYLKYASNQLTRNYYTQVCLASSTHVVKQTTKLSSFDIPNSDICTRPSNIFQNLRFLATSAQTRKKEAEVDSDGPRLNEKITGDYVRLVSEEGHCVVSLREALRRAKELQCDLVEVQRDAKPPVCKIVKYSLELYKKAKVGKERAKAKRAEAIRPDIKEIRFTPKIEAKDLKFKSDQALKLMESGYRVKCLAVPDKDKHKELEPEKLLELLFRFTCFIGDALVESWPEADRKGAVVIVRHAKFGPPKKGGVKLMKDIDIKSARVKEESPKPDSSKAGVATVDDQEDIEKSEPRFSVEQAQPVKFQNAYAKREPSSEFSGGRDASRFEPQSPNQHVNPQRPRFSNQAPNQQPTGRFDPQSPNQPPSAPRPQFPNQQPTGRFDPQFPSQPPRPQFPNQAPNQQSTGRFNPQFPNQRPSPPQSRFPDQAPNQQPSGPSPNRHPDRQGPPPRFQNQAPNQQPTGRFEPQPPNPPRAPPRPQTRLPNETSNEQPTAPGRSSGPASGYGIFSTPKTK
Protein: Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) (P07951)
Organism: Homo sapiens (Human)
Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775}.
Interaction partners:
- Tropomyosin alpha-1 chain
- Troponin I, fast skeletal muscle
- Tropomyosin alpha-4 chain
- Troponin T, slow skeletal muscle
- Troponin T, fast skeletal muscle
- Troponin T, cardiac muscle
- Myosin-3
- Actin, alpha cardiac muscle 1
- Troponin I, cardiac muscle
- Tropomyosin alpha-3 chain
Sequence:
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
Protein: Protein phosphatase 2C homolog 1 (PP2C-1) (EC 3.1.3.16) (P35182)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation.
Subcellular location: Peroxisome {ECO:0000269|PubMed:35563734}. Note=Peroxisomal localization is dependent on PEX5. {ECO:0000269|PubMed:35563734}.
Interaction partners:
- Mitogen-activated protein kinase HOG1
- NAP1-binding protein 2
- MAP kinase kinase PBS2
- Tyrosine-protein phosphatase 2
- Tyrosine-protein phosphatase 3
- Mitogen-activated protein kinase SLT2/MPK1
- DOA4-independent degradation protein 4
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
- Protein phosphatase 2C homolog 7, mitochondrial
- Osmosensing histidine protein kinase SLN1
Sequence:
MSNHSEILERPETPYDITYRVGVAENKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDEEINTKLVGNSGCTAAVCVLRWELPDSVSDDSMDLAQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVFL
Protein: Transcription termination/antitermination protein NusG (P0AFG0)
Organism: Escherichia coli (strain K12)
Function: Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNAP, probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA and phage lambda N-mediated transcriptional antitermination.
Interaction partners:
- Large ribosomal subunit protein uL11
- DNA-directed RNA polymerase subunit beta
- Small ribosomal subunit protein uS10
- Transcription antitermination protein NusB
- Transcription termination factor Rho
- Protein translocase subunit SecE
- DNA-directed RNA polymerase subunit beta'
- Transcription termination/antitermination protein NusA
- DNA-directed RNA polymerase subunit alpha
- Small ribosomal subunit protein uS3
Sequence:
MSEAPKKRWYVVQAFSGFEGRVATSLREHIKLHNMEDLFGEVMVPTEEVVEIRGGQRRKSERKFFPGYVLVQMVMNDASWHLVRSVPRVMGFIGGTSDRPAPISDKEVDAIMNRLQQVGDKPRPKTLFEPGEMVRVNDGPFADFNGVVEEVDYEKSRLKVSVSIFGRATPVELDFSQVEKA
Protein: DNA topoisomerase (EC 5.6.2.1) (F4JRX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT5G19950 protein
- DNA repair endonuclease UVH1
- Cysteine/Histidine-rich C1 domain family protein
- At5g02710
- Crossover junction endonuclease MUS81
- Crossover junction endonuclease MUS81
- DNA repair protein RAD50
- ATP-dependent DNA helicase Q-like 4A
- ATP-dependent DNA helicase Q-like 3
- ATP-dependent DNA helicase Q-like 5
Sequence:
MQRTISLAAAKSSSSTSVLSLHPLMAKLQCRAIQNFPASSSSSVVRVDRVYRNVSQLQFKRENSSCLKLACALPSHLSLLGSLSYATHWSSSTSRAFGYSFRPFARRYFSQVASTEIKDSIVGGVEKFGGNKIGFKKFNKKWKKHRVLASTKAEVVASTEPVIGDVNSGIKAKLSTAASPASNAKQASTVKTKRQPKSKKFEDKSSPTVSVLETVSVDESLQSFPKPRHSGSGNRKSSSAEYSSQKEVVKKTNVEGPKSSTPSNSMSEQQHWTSTKASNAPKQEQDNIVGGDEKAGGNKVGFKKFNKNRKKHNVLASSEAEVVTSTEPVIGDGSSGIKAELSTAASPASNGNQATTVKSKRRPKNKKVEDKSSSVVPVLEAVSLDESPISVPKPKHSGSGNRKSSSAKKEVAKNHPVEEPKSPAPSNSKSEQQHLKSTKASKAPKQKLVPQHMKNSIEHRGQNASKPLYPPSGKSVIVVESMTKAKIIQGYLGDMYEVLPSYGHIRDLATRSGSVRPDDDFSMVWEVPSSAWTHIKSIKVALNGAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVARVVFHEITESAIKSALQSPREIDGDLVHAYLARRALDYLIGFNISPLLWRKLPGCPSAGRVQSAALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEANAQDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKLAQKLYEGVQLSDGKSAGLITYMRTDGLHIADEAIKDIQSLVAERYGKNFTSDSPRKYFKKVKNAQEAHEAIRPTDIRRLPSTIASLLDADSLKLYTLIWSRAVACQMEPASIAQIQLDIGNASESIIFRSSCSKVEFLGYQAVYEDPEAKAIKNNDNDQSSEREETFKTLSSLKDGDLLQIGEVELKQHHTQHPPRYSEGSLVKKLEELGIGRPSTYASIFRVLQHRKYVTIKNRVLYPEFRARMVSAFLTHYFTEITDYSFTADMETELDNVSGGVTEWKGLLRDYWTRFSAYCKRVENVQRSQVEKMLEKKYEDVLFSLLPYPSRTCPSCMEGTLSFKASKFGAGYFIGCDQHPSCKFIAKTLYGEDEDEDDPPKNNCVEEPKLLGLHPNTSEKVILKCGPYGHYVQLGEDKKGHTPKRANAAHIKDVNSITLESALELLRYPLTLGTHPEDGQPVVLKLSKSGFTIKHRRNMATVPKNTEPGEVTLERAMKLLSGKNVRKSGRPPKSILPEEEKGDEEVVVAI