wanglab/gogpt-training-data huggingface dataset:
Protein: UBX domain protein 8 (A0A087WV67)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLTISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN
Protein: Serine/threonine-protein kinase (EC 2.7.11.13) (F8WBA3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000552}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
Protein: LD30894p (Q95TQ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLARCVLFVTWLAVFIATGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRCHLLRAQCGGHQVSLKYSGSCNACLEAVKFARRQQERDPGYFVPRCRKDGNFAAMQCYGNNGCWCSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNPDTSASKGSSEAGSTAHRTCSKSDRSQFNTNLMRMFRNEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQEIRELKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFHNRSAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYEDSATGYGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQCDESVAVRPMKGCTEPRKTQFLKELKAYLNTSLLPSSTTGSNSSMRKTDDERIATLSFVYLDKNKNKSWDRREWKNFRDLVTSASHLRRCGKKMPRYCDVNGDKKISLAEWLNCLQATPRESATTAKPAQSNETASPKFQGVNPVERYLKD
Protein: Cation channel sperm-associated protein 3 (CatSper3) (Ca(v)-like protein) (One-repeat calcium channel-like protein) (Q86XQ3)
Organism: Homo sapiens (Human)
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q80W99}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80W99}.
Interaction partners:
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated protein 2
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated protein 4
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated auxiliary subunit epsilon
- Cation channel sperm-associated auxiliary subunit zeta
- Pterin-4-alpha-carbinolamine dehydratase 2
- Cation channel sperm-associated auxiliary subunit gamma
Sequence:
MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK
Protein: SON DNA and RNA binding protein (H7C1M2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XRSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSEPVDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRKGLVAVGERAQKRSGNFSAAMKDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRKHFLFRVLINGSAYQPSFASPNKKHAKATAATVVLQAMGLVPKDLMANATCFRSASRR
Protein: Protein DJ-1 homolog B (AtDJ1B) (Q9MAH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in oxidative stress response.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:20406884}.
Interaction partners:
- DJ-1 protein homolog F
- DJ-1 protein homolog E
- Hydroxyacylglutathione hydrolase cytoplasmic
- Probable hydroxyacylglutathione hydrolase 2, chloroplastic
- Hydroxyacylglutathione hydrolase 2, mitochondrial
- Hydroxyacylglutathione hydrolase 1, mitochondrial
- Persulfide dioxygenase ETHE1 homolog, mitochondrial
- Lactoylglutathione lyase GLX1
- ADP-ribosylation factor-like protein 8a
- Superoxide dismutase 3
Sequence:
MASSSLCHRYFNKITVTPFFNTKKLHHYSPRRISLRVNRRSFSISATMSSSTKKVLIPVAHGTEPFEAVVMIDVLRRGGADVTVASVENQVGVDACHGIKMVADTLLSDITDSVFDLIMLPGGLPGGETLKNCKPLEKMVKKQDTDGRLNAAICCAPALAFGTWGLLEGKKATCYPVFMEKLAACATAVESRVEIDGKIVTSRGPGTTMEFSVTLVEQLLGKEKAVEVSGPLVMRPNPGDEYTITELNQVSWSFEGTPQILVPIADGSEEMEAVAIIDVLKRAKANVVVAALGNSLEVVASRKVKLVADVLLDEAEKNSYDLIVLPGGLGGAEAFASSEKLVNMLKKQAESNKPYGAICASPALVFEPHGLLKGKKATAFPAMCSKLTDQSHIEHRVLVDGNLITSRGPGTSLEFALAIVEKFYGREKGLQLSKATLV
Protein: rRNA processing protein, putative (Q38CZ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Pescadillo homolog
- Ribosome biogenesis protein, putative
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar complex protein 2
- RNA-binding protein, putative
- Ribosome biogenesis protein NSA2 homolog
- RNA processing factor 1, putative
- Ribosome biogenesis protein NSA1
- NLE domain-containing protein
- 60S ribosome subunit biogenesis protein NIP7 homolog
Sequence:
MPVYDVAVSKSKKRKLSTDGVDPPPVRGEERRRVEKQVETAPADNREGNGNAERLTTVEFSEPAQWVERMALTSTKPLPSDLNADDDPKREEAFIQQALLSVVRGISLLEAGDVPWKRPDDYYAEMFKDDVQMSRIASAMEKSKARIEERAHRRAMKDQKKYGKEVQAEVLRQRAKYKRDMGARISEWRRKRKGNEDLDDILNADETTSGSKGRGAARGVRGGGTTRAPRQKNLRPGGVKRRPGKNARRRR
Protein: Slowpoke 2, isoform G (A0A0C4DHC4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSRLIQPRYRFRDLLLGDFSFNDDGERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATASENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNSRRKSNISFCSNINLGATCGPQMPQMNMNMANTAVGAGSRRGSGIAGLNPMQMQSVQTLAGYGSSSQRCSPPMQQIKSNSLSLPDSPTVVGNQRGRSNSLRIDNDILLRRSSSLRQGLPSVGVSHGRRKSSLEEIGISHFTTLMQATNHSNPIKISLNGSIGMENQISLQVTPPEEPTPMLGVPCMLGGGGGGGINPSGAGSSTGGMLGGGSSLAINTADLGPGPSTSSGASGSLQAQDSLGQQSSQVSSPQHLQGTIV
Protein: E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) (Q00987)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis. Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis.
Subcellular location: Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:30879903}. Nucleus, nucleolus. Nucleus {ECO:0000269|PubMed:30879903}. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
Interaction partners:
- Retinoblastoma-associated protein
- RAC-alpha serine/threonine-protein kinase
- Ubiquitin-conjugating enzyme E2 D2
- Ubiquitin carboxyl-terminal hydrolase 7
- Cyclin-dependent kinase inhibitor 2A
- Protein Mdm4
- Histone acetyltransferase p300
- Cellular tumor antigen p53
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL18
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Protein: Calcium channel (Q5BE62)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein
- Calmodulin
- Calmodulin
Sequence:
MASNSHDRGSSDENDIADHSIPLQDLTGPQERGRRLSRVGSRLFSGRSLTERGRPYERLSEDSPVEHGGHTTGSHSAEGANQFNVEDPGAFAAAMSSVGLGLEVSGFQHSQPSASHLAAHTRDESESDMEFVRIDSVDPHEAEHYLSPSEIYPDTTPLTSIRHVQPISGASITPSGSQDPSNAPSVRFDDSQMGSRLGDDLHNMESGYSGRRRAESVSKDGGRSLSPSVSGSALLRASSMMKSVSQRVVNLSNEPEVVERSLSRDSHKSSRMEAPPSLPSLTDYAHDAPSSSSLNEQSAREKSVNSKAWKGLSNPLRGKALGFLGPDNALRMWLCDILVHPLTEPFILVIIVVQTILLTIESAQSEWSHPRLPHWGLNRMDYPYFVIFIIYTVELIAKILVSGLFFNPTEYSTIDRSKGITTALMEKGKNLITPQRQFSIRKSSAQPEPQQASIIRTFTGGLNQLEQQLADDPLQKRRIRLAHRAFLRHSFNRLDFVAVLAYWVSFVLNLGGVENTHQLYVFRMLSCLRILRLLALTSGTSVILRSLKKAAPLLVHVAFLIGFFWLLFAIVGIQSFKSSFRRTCVWLGEEYGEQNFTMNDPFGTLQFCGGWLDETGTQRPWYSSDGFESDSKPKGFICPQGSICVEGGNPYNTTMSFDDILHSLELVFVIMSSNTFTDILYNTTDSDYLVAALFFACGFVILSLWMVNLLVAVITHSFQVIREESKRSAFASQKIEASEEEEESSRKVSTLKRIYDATYWFWIAVIIFDLVMQAQRSSSMGDGRVQLIDNCEIVVTVALLGEILLRFISDWRKFHQSRRNWVDLALAIITCIIQVPAIRNSKRTYDILTVFQILRFYRVVLAFAVTRNLITLVFRNAVGLLNLILFVFLITFLASIFATQLFRSQIPREDDDGGTIEITFSDLYNSFLGMYIILSSENWTETLYNVTSYTYSFNTAWISATFVILWFIVANFIVLNMFIAVIQESFDVSEDEKRLHQVRAFLEQKQVGSASQGNLSLSKILKLGRGSARFKDPLDHGPAALDMLLKDAVVREFLDEEMPENQRREEASIARTATTAEGLVEPGVFSRLWTSVTSSVLRREPNPFYSKLKISRAYEELGPQEMVREVVSAEQQRKREQREYLIRHPTYNTSLFLFKPDNPVRRLCQRMVGPGRGSQRVEGVDPYKPVWYTFTAVVYAAIVAMVILACITTPIYQAVNFQTDRDWFTYTDLGFAILFSIEALIKVIADGFFWTPNAYFRGSWGFIDGIVLVTLWINVLSALSSERGVSRAIGAFKALRALRLLNFSDSAKNTFHSVIIVGGWKVIAAALVSMSFLIPFAIYGVTLFNGQLMECNDDGIAGSLDACVGEFMSSPFNWDVLAPRAVSNPWYDFDNFGNSLFILFQIVSQEGWTAVQSSVMSITGLGRQPETFAAPENGLFFVVFNLLGAVFVLTLFTSVFMRNYTEQTGVAFLTAEQRSWLELRKLLRQVSPSKRRSSEKSTSWKQWAYRVAYKKHGRWAKCVTTVLVLHLILLVIEYYPENYLWNLARDGLFFLFNFVYIANVLLRLVGLGWHRFSTSSWDMYALLVVPSTVITSILNFTSYEQRKTIEVLNKLFLVAITLLLIPRNNQLDQLFKTAAASFTSIGNLLATWFVMFLVYAIAMNQAFGLTKFGGNENGNINFRDIPRALILLFRTSCGEGWNELMEDFATMEPPLCTAITDGFFGNDCGSKGWARALFISWNIISMYIFVSLFVSLIFESFSYVYQRSSGLYVISREELRRFKQAWAEFDPEGTGYITKEQFPRLLRELTGIFEVRIYQGDFMVPRILDECRVDKRDSLLAHRRVVEGVDLDKLAKIIRKIPVNTVRERRKRLNELYEEVLVSADPRYGITFHSCLMILAHYNVISDSKSLRLEEFLRRRAKLQRVEEAVRRNTVIGFFKTLTATREFRRKIEHKRSARMTFVPQFNVPEIYVDDELQEDQQSQDGPLGSARSSGAEPSMLSPTSTGRGEAGPSQLPRINTNVGDRMNSEASSPSEWSNISISLSPGRERAHTTSSYDPPSFSEGASATSEHSRHHSAMAVQDVMQSLGDSAWGESIRRSFTQRRPRERPRDET
Protein: Female sterile (1) M3 (Q9W451)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Protein trunk
- Chorion peroxidase
- EG:8D8.1 protein
- Deubiquitinase otu
- Vitellogenin receptor Yl
- Maternal effect protein oskar
- Closca
- pH-sensitive chloride channel 2
- Tubulin alpha-4 chain
- CG5272 protein
Sequence:
MISPSVCAALFSVLVLNSYIAQVQSELSAAEVAGDPSAAQLLPSSCRNGLNGSSSGPEIRLPFVDMMVRHEKPLFVLREPEEDLLLLLHGHEIFQLHVATGERRLVPLGYLAGQVSGRRALGAEVVAWREFLLLAIVLDDSMEVYQLPKELLLSEDPATQVSFEPLQEFSLPGAFLQLHLLKPSGDQVLLLVASNHTRSHSKCRTFEWLDTYFNPLEEITLPAIRVLQVVGRQPLYIIFGRSLKGSQSKLVLTIYELDRNSRILQQRQALTVQAQSVQAVRFHGRNCLIACTSSASASCIFFRMVDGQFVVYRKHARKDLSFRRLSATKKGHLLIGARANGEVIVFSSTRLDCYSGFQVAGEADPSGLLIHKNLHNETFLLLAYRRSSSDLIRTVQLGGVEEISNQVGAAPDEDLSVVQLHRHEFEESINALRGLLLRRRSSTENLRNIVDILKRKSAIHLDTPLHLVQQGQIGRLQLVDEHLRTPTQLKQRLEELRQRFKAIQTRRTTRSFGTGNENDEPETLKARRLRVGNLIYKGQLISGHILDNSKPPMLTIRNSPLQTKKLRVNQLVTPQDFRNSSGAQIAPEETSGSECVVRHLRVEQINGVQWNDFLDSLFLRSRDTSIEGRLVMQSRVRVNSLKTPLLNGLVVDRLFNLRRAQVISSNIYMSAFFAPRLEAQQVNGLDFAHDVLHRGSNDTWIKTPVRINQMSVSGDIFVGNTSKWQPQPRQLDDPMEQRLQQYYTGRVTIRGSLTVTNVLRDTANSLIVLGNQSLARKDIQSTYLLDQTPQNLTNLTFGHARVSVPSMTTSYVDGHPVRDHLLSGGQQNQHTHPNNTLHIIFMNATILGDVICRDYSSRLAEIAKDAVSHGDAVNITGHKHFQAPLTVQALQANEINGVPVSEIVVKSNTTQNFTGTKTFARVVVANDINVHDHLNVSHLNGLPLQQLLGHDISLQRLELTETPHLENLHFRRLNGLPFDELLSKISEDGEQPLLLHKQLLIEGNVRFDKAVQVQNINGIQWDEYLDRLVRSDSNAEIRGKKTFMADVQINDALQSPHINNLDLSSLLDNTLLRMTPQQISGAYTFDRMMATNVDVNRINGVPKEEFIDTRKDLELKGDLYLKQLNINGSLKCPFVNEAVLNDLKQRVEQVQQLPWRNLIVTGDALWDGEEQSQSQLDYLRQHAVRRVGNQTIAGHVLLKEPYLKDIQSKHSLPIDLNFTQLAEDALLRRSPTNETQVITAPQELQGLVRANTLHLEQDAHFELVNGIDIRRFNASLYRLSSGEAIAADLHFHQAPKIGKLQLEYPEVNGAPIQSIYQQGKGQSWPPVTFKNLFVEQDLNLKTVNNMNLDYFLQHRIPLKGDALEVFGSLTFEHLQLSGKPLLRSINGIQLDNLVFRHSNRTQSITGAKTFRGGVEFTGPGHVMNLNGRELSESFRGSIFRNKDYNIDSLVLDKALFPGGLVLAGLQSQIPNRMRATEVQSNPLEEFQELLALGNQTSPRRLLYLDHDTESLESTWVKGPFRGSSELQVSLPLGYSAPCQRRTLQAKLLIHERRVLLANSSVSNQLMRLHSGDIRVKVQNHCHRPARRLRSRIRISCRNETHTLGMRQSVEAMELLEMGEMVLLLLGTEEEVRVLRLKRSNCSLTDWQSVLPADGRLMKLVRMGVESRQDLILTSGMSNHRPVLAIHYRDPLNHNFKMLQLIQGSYDLAEMQGNQLLVSCLGCRHIAIFKRYSHSAEILFEPIQQLSFQERIQQLTPFKVGNEQYLLVVTQPEEEHFYLFSYNEVGGWQQRTFGIKKQDQWAWSLVKSGQMLEAAETPILLLCGKKRECSLVKALLG
Protein: Probable LRR receptor-like serine/threonine-protein kinase At1g07560 (EC 2.7.11.1) (C0LGD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Transmembrane protein
- Protein MODIFYING WALL LIGNIN-2
- At5g55620
- WAT1-related protein At4g01430
- Cysteine-rich repeat secretory protein 55
Sequence:
MKNLRGLLLAFLVLSLGISDFLRAQDQQGFISLDCGLQADESPYTEPLTKLTFTSDADFIKSGKSGKIQNVPGMEYIKPYTVLRYFPDGVRNCYTLIVIQGTNYLIVAMFTYGNYDNLNTHPKFDLYLGPNIWTTVDLQRNVNGTRAEIIHIPRSTSLQICLVKTGTTTPLISALELRPLRNNTYIPQSGSLKTLFRVHLTDSKETVRYPEDVHDRLWSPFFMPEWRLLRTSLTVNTSDDNGYDIPEDVVVTAATPANVSSPLTISWNLETPDDLVYAYLHVAEIQSLRENDTREFNISAGQDVNYGPVSPDEFLVGTLFNTSPVKCEGGTCHLQLIKTPKSTLPPLLNAIEAFITVEFPQSETNANDVLAIKSIETSYGLSRISWQGDPCVPQQLLWDGLTCEYTNMSTPPRIHSLDLSSSELTGIIVPEIQNLTELKKLDFSNNNLTGGVPEFLAKMKSLLVINLSGNNLSGSVPQALLNKVKNGLKLNIQGNPNLCFSSSCNKKKNSIMLPVVASLASLAAIIAMIALLFVCIKRRSSSRKGPSPSQQSIETIKKRYTYAEVLAMTKKFERVLGKGGFGMVYHGYINGTEEVAVKLLSPSSAQGYKEFKTEVELLLRVYHTNLVSLVGYCDEKDHLALIYQYMVNGDLKKHFSGSSIISWVDRLNIAVDAASGLEYLHIGCKPLIVHRDVKSSNILLDDQLQAKLADFGLSRSFPIGDESHVSTLVAGTFGYLDHEYYQTNRLSEKSDVYSFGVVLLEIITNKPVIDHNRDMPHIAEWVKLMLTRGDISNIMDPKLQGVYDSGSAWKALELAMTCVNPSSLKRPNMSHVVHELKECLVSENNRTRDIDTSRSMDINLSFGTDVNPKAR
Protein: Glycine cleavage system H protein (Q8II35)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Aminomethyltransferase, mitochondrial, putative
- Serine hydroxymethyltransferase
- Aminomethyltransferase, putative
- Dihydrolipoyl dehydrogenase
- Dihydrolipoyl dehydrogenase, apicoplast
- Lipoate-protein ligase B
- Lipoyl synthase, apicoplast
- Bifunctional dihydrofolate reductase-thymidylate synthase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast
- Lipoate--protein ligase 1
Sequence:
MINIRKVLLPSCVITKSFLNNYYKRLITYYTKTHEYIKIEDGNLNNRKDMTNVKCKIGISNYGTHKLGEIVYVDVAHNINDHVKKGDCIATIESVKSVGDVYTPVSGKIININNKIIDNVNLMNEQSEIDGWIMELETNQINEKEIMNISEYEKMCEEEEQNEEKKIQQNEINCMEEKNKNKIFDINDMKNIENKGQGGK
Protein: Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) (Q86V25)
Organism: Homo sapiens (Human)
Function: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19204325}. Secreted {ECO:0000269|PubMed:20736312}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:31235911}. Note=Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). Associates with microtubules (PubMed:31235911). {ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:20736312, ECO:0000269|PubMed:31235911}.
Interaction partners:
- Small vasohibin-binding protein
- Tubulin alpha-1B chain
- Tubulin alpha-1A chain
- Tubulin beta-2B chain
Sequence:
MTGSAADTHRCPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWMHVAKVHPKGGEMVGAIRNAAFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRREKSPALPEKKVADLSTLNEVGYQIRI
Protein: Secretin GspD (Cholera toxin secretion protein EpsD) (General secretion pathway protein D) (GspD) (Type II secretion system protein D) (T2SS protein D) (P45779)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane. This subunit forms the outer membrane channel.
Subcellular location: Cell outer membrane {ECO:0000305|PubMed:28067918}. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane. {ECO:0000305|PubMed:28067918}.
Interaction partners:
Sequence:
MKYWLKKSSWLLAGSLLSTPLAMANEFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRSFDTLNEEQYYSFFLSVLEVYGFAVVEMDNGVLKVIKSKDAKTSAIPVLSGEERANGDEVITQVVAVKNVSVRELSPLLRQLIDNAGAGNVVHYDPANIILITGRAAVVNRLAEIIRRVDQAGDKEIEVVELNNASAAEMVRIVEALNKTTDAQNTPEFLKPKFVADERTNSILISGDPKVRERLKRLIKQLDVEMAAKGNNRVVYLKYAKAEDLVEVLKGVSENLQAEKGTGQPTTSKRNEVMIAAHADTNSLVLTAPQDIMNAMLEVIGQLDIRRAQVLIEALIVEMAEGDGINLGVQWGSLESGSVIQYGNTGASIGNVMIGLEEAKDTTQTKAVYDTNNNFLRNETTTTKGDYTKLASALSSIQGAAVSIAMGDWTALINAVSNDSSSNILSSPSITVMDNGEASFIVGEEVPVITGSTAGSNNDNPFQTVDRKEVGIKLKVVPQINEGNSVQLNIEQEVSNVLGANGAVDVRFAKRQLNTSVMVQDGQMLVLGGLIDERALESESKVPLLGDIPLLGQLFRSTSSQVEKKNLMVFIKPTIIRDGVTADGITQRKYNYIRAEQLFRAEKGLRLLDDASVPVLPKFGDDRRHSPEIQAFIEQMEAKQ
Protein: Somatic embryogenesis receptor kinase 5 (AtSERK5) (EC 2.7.11.1) (Somatic embryogenesis receptor-like kinase 5) (Q8LPS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-kinase of unknown function.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEHGSSRGFIWLILFLDFVSRVTGKTQVDALIALRSSLSSGDHTNNILQSWNATHVTPCSWFHVTCNTENSVTRLDLGSANLSGELVPQLAQLPNLQYLELFNNNITGEIPEELGDLMELVSLDLFANNISGPIPSSLGKLGKLRFLRLYNNSLSGEIPRSLTALPLDVLDISNNRLSGDIPVNGSFSQFTSMSFANNKLRPRPASPSPSPSGTSAAIVVGVAAGAALLFALAWWLRRKLQGHFLDVPAEEDPEVYLGQFKRFSLRELLVATEKFSKRNVLGKGRFGILYKGRLADDTLVAVKRLNEERTKGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPEGNPALDWPKRKHIALGSARGLAYLHDHCDQKIIHLDVKAANILLDEEFEAVVGDFGLAKLMNYNDSHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQKAFDLARLANDDDIMLLDWVKEVLKEKKLESLVDAELEGKYVETEVEQLIQMALLCTQSSAMERPKMSEVVRMLEGDGLAERWEEWQKEEMPIHDFNYQAYPHAGTDWLIPYSNSLIENDYPSGPR
Protein: Synaptotagmin-9 (Synaptotagmin 5) (Synaptotagmin IX) (SytIX) (Synaptotagmin V) (Q925C0)
Organism: Rattus norvegicus (Rat)
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
Interaction partners:
- Vesicle-associated membrane protein 2
Sequence:
MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPRLRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLFSGSKDNNQEPLNYTDTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQPGGQDNCAHAVRVQRQVTEPTPSARHNSIRRQLNLSNPDFNIQQLQRQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVHYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFFDLADFPRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQIHLSIAVMDYDRVGHNEVIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLLEKR