wanglab/gogpt-training-data huggingface dataset:
Protein: Elongation factor 1-alpha 2 (EF-1-alpha 2) (eEF-1A2) (Q8W4H7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Probable elongation factor 1-gamma 2
- Adenylyl-sulfate kinase 4, chloroplastic
- Adenylyl-sulfate kinase 1, chloroplastic
- Adenylyl-sulfate kinase 2, chloroplastic
- Adenylyl-sulfate kinase 3
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS8z
- Small ribosomal subunit protein uS3y
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein eL19x
Sequence:
MGKEKFHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKARYDEIIKEVSSYLKKVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLEALDQINEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGMIKPGMVVTFAPTGLTTEVKSVEMHHESLLEALPGDNVGFNVKNVAVKDLKRGYVASNSKDDPAKGAANFTSQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFSEILTKIDRRSGKEIEKEPKFLKNGDAGMVKMTPTKPMVVETFSEYPPLGRFAVRDMRQTVAVGVIKSVDKKDPTGAKVTKAAVKKGAK
Protein: glycerophosphodiester phosphodiesterase (EC 3.1.4.46) (F4HQ30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNSRPSNPTKLVIRSSTLLFCGVVLIHLFAAQIDAQRSTSRWQTLNGESCSHFISFFCALFPRKQENLCDAPLVIARGGFSGLYPDSSIAAYQLATLTSVADVVLWCDLQLTKDGLGICFPDLNLANASTIDRVYPNREKSYSVNGVTTKGWFPNDFSLTELQNFLLIRGILSRTDRFDGNGYLISTIEDVVTTLNREGFWLNVQHDAFYEQQNLSMSSFLLSVSRTVSIDFISSPEVNFFKKITGSFGRNGPTFVFQFLGKEDFEPTTNRTYGSILSNLTFVKTFASGILVPKSYILPLDDEQYLVPHTSLVQDAHKAGLQVYVSGFANDVDIAYNYSSDPVSEYLSFVDNGDFSVDGVLSDFPITASAAVDCFSHIGRNATKQVDFLVISKDGASGDYPGCTDLAYEKAIKDGADVIDCSVQMSSDGVPFCLRSIDLRNSIAALQNTFSNRSTSVPEISSVPGIFTFSLTWPEIQSLTPAISNPFRVYRIFRNPREKNSGKLISLSQFLDLAKTYTSLSGVLISVENAAYLREKQGLDVVQAVLDTLTEAGYSNGTTTTKVMIQSTNSSVLVDFKKQSKYETVYKIEETIGNIRDSAIEDIKKFANAVVINKDSVFPNSDSFLTGQTNVVERLQKSQLPVYVELFRNEFVSQAYDFFSDATVEINAYIYGAGINGTITEFPFTAARYKRNRCLGREEVPPYMLPVNPGGLLNVMSPLSLPPAQAPNQDFIEADVTEPPLSPVIAKAPTSTPGTPSTIAQAPSGQTRLKLSLLLSVFFLSLLLL
Protein: Tryptophan 2-monooxygenase (EC 1.13.12.3) (E0SI85)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- Indoleacetamide hydrolase
- Amidase
- Tryptophanase
- RNA polymerase-associated protein RapA
- Tryptophan synthase alpha chain
- Tryptophan synthase beta chain
Sequence:
MLTFWGGYMSNDASFLANSVPCVDLLYDYAPFLQCSEAEGRIGYFPPGIPTPRVAIIGAGISGLVAATELLRAGVKDITLFEARDRRIGGRVWSQTFDPRYPHLIAEMGAMRFPSSETCLFYYLNKLDIATTTSFPDPGVVDTELHYRGVRHIWSAGDPPPSLFSRVHEGWVALLNEGYLHNGVPLVAPRDITAMLKSHCFDKARKAWQAWLDAFRDYSFYSALVTMFTSNTPPGGVPWRRPDDFELFGSLGIGSGGFLPVYQAGFTEILRLVINGYEDDQRLIIGGISTLAERLVSQKIGDTRLSEHICFNEVKRIYKEDGEIKLVSGKGQTHTFDRVIVTSSTRTMQIVHCLTGDETFLEHDISRAVKETHLTGSSKLFMLTRNKFWLNDSLPVTIQSDGFIRGVYCLDYEPDNPDGPGVVLLSYTWEDDAHKLLSIPDKKQRCQYLVDDLAKINPEFARHLIPADGDYERYVLHHDWLVDPYSAGAFKLNYPGEDVYSQRLFFQFKNANTPEKDTGLYLAGCGCSFTGGWIEGAMQTALNSACAVIRSSGGALLVGNPLDDMHSAYCY
Protein: Uncharacterized protein (Q38FU7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPRGERIHSIKGSPEKRRGKHNMEKLEREDHSSGHREDGKQCASSVEQPKGIRKCPCKREREPPDADILHGSFIASDLQTRMDTIYTHMVRRMLPTQSKFISEAGIMEEADGATLTFEVQNKGAAIAMRDRLQNTVVCGRQWKVEIFPLKETQCSKEACLVDVLLVPPAPRTLVLRALNGAKGFLSLVDVEDTVIATPVSVPTERESVDSEIDSNRSFPLDPSFNEATNGNNGAVDLEERVLASFVDEGSAQNARAVLSGRLIGTSGVRMFLERHR
Protein: Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) (Q9NZ63)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides. May also modulate exon inclusion events. Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity. Binds U5 snRNA. Required for proper chromosome segregation. Not required for splicing of shelterin components.
Subcellular location: Nucleus {ECO:0000269|PubMed:35167828}. Chromosome, centromere {ECO:0000269|PubMed:35167828}. Note=Dispersed throughout the nucleus during interphase (PubMed:35167828). Colocalizes with microtubule attachment sites at centromeres following mitotic checkpoint activation (PubMed:35167828). {ECO:0000269|PubMed:35167828}.
Interaction partners:
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-processing-splicing factor 8
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 17
- Mediator of RNA polymerase II transcription subunit 22
- Peptidyl-prolyl cis-trans isomerase-like 1
- Pre-mRNA-splicing factor 38A
- Probable ATP-dependent RNA helicase DHX35
- 116 kDa U5 small nuclear ribonucleoprotein component
Sequence:
MPVVRKIFRRRRGDSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY
Protein: ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2) (Q9UG63)
Organism: Homo sapiens (Human)
Interaction partners:
- ATP-binding cassette sub-family E member 1
- Large ribosomal subunit protein bL20m
- ATP-dependent translocase ABCB1
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL14
Sequence:
MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEEPQLTKRTHNV
Protein: Suppressive immunomodulating factor (Q57ZX3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLTLRELDPSELEDEAHLRRFEQCRCEVMRVSSSRLLPECIALTTKGGFVQLVNVSTGAFRVFLTHLGNMPLESQLRCFSLAPSLYATKGAHSLLYSLAYSNELLLADMEQGTVSVLATFQSRPSVVYCDGDYIVCGEGSGQVTLWRSPSATDGDATIEWRRSVFTDTVVCITLQRAYVVCSSVDQHSYVLSLRGGDIIAKLAQGPEAAVSLQSVTTSQLSGGFMLLCLPTVLTVYAPPNKEVAAPPCPTDGTVWDCSNSVQLDTQINCLSCCVGLIACGTASGVVILMTMDETGREVVERVRFNVGFAVVCVQLFDDDTLVVVTSSGDVWKWTTTDLLPEEPACDLSGEEELPEPNVQPPTATSAAPRPTHESMGLDNPQIVQVTSSEVVNPGYLNECGKEEEEEITIMMDDESHPLPSRVSTLPSRHPVNLRTHCREGSDNKNVGDYQEIFDTPNEVLAHMAECSGDRSDHMPTCARTRSPSGTVTESETFSDDGSSCSSRSSSPSSVSVAGYATADVAADRITNGAIQSSPPSEQNLRSISRDAAGDFAVDVDATLTSSPGTCACPPVLEAGLTTADAVAVAACNEVTERGGEVCSPTRYTLTHTLDKVLRAVDVVPPLTIKGLCAGRRMDPRKAKLIAETDCHEEPAPGPERQSSQMLMDYREGLEDTPFDYAAYAGAHPLKTEALKYRYPVRMPVYSTRAQLFTPSTELRVTNIKGNSEENNMEVNRKKESRQDHNDQQENVTNFTIADDLMNATYGRLTRRKDPLLEEERQLGGPDIRRHSCGGLLCGTVDPNGTVLFQEFRVQPSPPGLLLLPMPLPPTPTVF
Protein: GEO08248p1 (Orcokinin, isoform A) (RH09340p) (Q9W1F8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cardioactive peptide
- Allatostatin C, isoform A
- Bursicon
- Neuropeptide F
- Short neuropeptide F
- Protein PDF
- Allatostatin-A
Sequence:
MNLYVLLAVVSVFLNFIHAAPGVDISNDELLDGKYLCEAGSKKYDGPFIVRLISAANGQTVVCYECSQSEFKTKYSVKQCAAGKIGSGHHRDLVPYLVRMDPLYKDTWSSKLKRNFDEIDKASASFSILNQLV
Protein: Small ribosomal subunit protein uS19x (40S ribosomal protein S15-4) (Q9FY64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein eL15z
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS1z
Sequence:
MADVEPEVAAAGVPKKRTFKKFAFKGVDLDALLDMSTDDLVKLFSSRIRRRFSRGLTRKPMALIKKLRKAKREAPAGEKPEPVRTHLRNMIIVPEMIGSIIGVYNGKTFNQVEIKPEMIGHYLAEFSISYKPVKHGRPGVGATHSSRFIPLK
Protein: Aspartate-beta-hydroxylase (A0A096MKE0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004157}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004157}.
Interaction partners:
Sequence:
MAPRKNAKGGGGNSSSSGSGSGSGSPSTGSSGSSSSPGARREAKHGGHKNGRRGGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDADGDGDFDVDDAKVLLGLKERSTSERTFPPEEAETQAELEEQAPEGAEAQNVEDEVKEQIQSLLQESVHTDHDLEADGPAGEPQSEVEDFLTATDSDDRFEALEPGTVHEDTEDSYHVEETASQNHPNDAEEVMSEQESSDHGEAVTDDGLQQHAEEVRHEDYDEPVYEPSENERIEISDNAIDDSNIISEEINVASVEEQQDTPPVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVSAFEELVRRYPQSPRARYGKAQCEDDLAEKQRSNEVLRRAIETYQEAASLPDAPTDLVKLSLKRRSERQQFLGHMRGSLLTLQRLVQLFPSDTTLKNDLGVGYLLMGDNDSAKKVYEEVLNVTPNDGFAKVHYGFILKAQNRIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPRETGYTELVKSLERNWKLIRDEGLMVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRKNENACKGAPKTCTLLEKFSETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETRSWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
Protein: Uncharacterized protein (Q9D4T2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MIGPARSWDTASGEELHTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIWR
Protein: Embryo defective 2737 (F4JYQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alanine--tRNA ligase, chloroplastic/mitochondrial
- FAD/NAD
- Pentatricopeptide repeat-containing protein At1g30610, chloroplastic
- Probable purine permease 10
- Small ribosomal subunit protein uS5c
- Ankyrin repeat domain-containing protein EMB506, chloroplastic
- Aspartic proteinase PCS1
- Gb|AAF56406.1
- Protein translocase subunit SECA2, chloroplastic
- Early nodulin-like protein 1
Sequence:
MSRGPGRLIQNVTQFADAQFKQFSTRYGQQVIDILDFPIKLVLSPFTLAFDIAGSAPRGFGIPEFISKISYLSVFAVATLGTYDIALDLGKKVICQRDCKTCNGWQALRCTMCKGTGSVHYQIKDYNLRSGEKPTADCVADAIVENRAELVHLPSSFNHSAPLPSKDCPTCDGTGAMSCTECKNKLQVRISADDIMEPPWKAYNVLKKMDYPYEHIVHSMKDPSIANFWLITLPQIVGGFDYDEDVKKKIWWQYELNLLNPHLGWFCYTNIVSIPYLDRFVLWNWRHLWDTDESMRYDQLRDLVAKRNPGWEYLQDALVSIDPVRAREDPVIVKNVPYYKAKKSLEAEVTKLNPPPRPQNWGELNLPLNISSWSEEDLKNPAKLYEKTVLLNAQREIADKILDAQWEAKWRQEKVEEMLEQKVRPYIQDSSMAVLPQPILLKSQKKAQKGSRQRKWWFF
Protein: Protein Wnt-11 (O96014)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-6
- Frizzled-7
- Frizzled-9
- Frizzled-3
- Frizzled-4
- Frizzled-8
- Tyrosine-protein kinase RYK
- Frizzled-2
- Frizzled-1
- Frizzled-5
Sequence:
MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
Protein: Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (A0A8I6GKL5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGRLWCKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVVSTSCKINGSFDPSFRPLKTCECTSPEYKTIP
Protein: Prohibitin-4, mitochondrial (Atphb4) (Q9LK25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17883375, ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:21841088}; Single-pass type II membrane protein {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17883375, ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:21841088}.
Interaction partners:
- Prohibitin-6, mitochondrial
- Prohibitin-2, mitochondrial
- Prohibitin-1, mitochondrial
- Prohibitin-7, mitochondrial
- At5g54100
- At5g40700
- Flotillin-like protein 3
- Expressed protein
- Hypersensitive-induced response protein 4
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MGSQQVAISFLTNLAKAAFGLGVAATALNSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPYLQTPHIYDIRTKPHTFSSKSGTKDLQMVNLTLRVLFRPEVSRLPYIFQTLGLEYDEKVLPSIGNEVLKAVVANFNADQLLTERPQVSALVRDALIKRAREFNIELDDIAITHLSYGAEFSRAVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAATLARSPNVAYLPGGQSMLFNLNPGR
Protein: Sirohydrochlorin cobaltochelatase CbiKP (EC 4.99.1.3) (Sirohydrochlorin ferrochelatase CbiKP) (EC 4.99.1.4) (Q72EC8)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the insertion of Co(2+) into sirohydrochlorin. To a lesser extent, is also able to insert Fe(2+) into sirohydrochlorin, yielding siroheme. Its periplasmic location means that it cannot participate in cobalamin biosynthesis and its genomic environment suggests it is likely to be associated with a heme or metal transport system.
Subcellular location: Periplasm {ECO:0000269|PubMed:18457416}.
Interaction partners:
- Precorrin-2 C20-methyltransferase
- Precorrin-4 C11-methyltransferase
- Cobalamin biosynthesis protein CbiG
- precorrin-2 dehydrogenase
- Sirohydrochlorin cobaltochelatase CbiKC
- Precorrin-3b C17-methyltransferase
- Cobalt-precorrin-5B C
- Precorrin-8X methylmutase
- Iron compound ABC transporter, permease protein
- Iron compound ABC transporter, periplasmic iron compount-binding protein, putative
Sequence:
MSRHPMVTRLLCLVFSCLIILACSPAFAGHGAPKAQKTGILLVAFGTSVEEARPALDKMGDRVRAAHPDIPVRWAYTAKMIRAKLRAEGIAAPSPAEALAGMAEEGFTHVAVQSLHTIPGEEFHGLLETAHAFQGLPKGLTRVSVGLPLIGTTADAEAVAEALVASLPADRKPGEPVVFMGHGTPHPADICYPGLQYYLWRLDPDLLVGTVEGSPSFDNVMAELDVRKAKRVWLMPLMAVAGDHARNDMAGDEDDSWTSQLARRGIEAKPVLHGTAESDAVAAIWLRHLDDALARLN
Protein: Lycopaoctaene synthase (EC 2.5.1.148) (Squalene synthase-like LOS) (EC 2.5.1.21) (A0A142ZC57)
Organism: Botryococcus braunii (Green alga)
Function: Converts the C20 geranylgeranyl diphosphate (GGPP) to the C40 lycopaoctaene, the first committed intermediate in the production of lycopadiene. Converts farnesyl diphosphate (FPP) into squalene, a precursor for sterol biosynthesis in eukaryotes. Converts with low efficiency the C20 phytyl diphosphate (PPP) to the C40 lycopadiene in vitro. This reaction may not have biological significance in vivo.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKYTDFLAHPDEIIPTIRMMYADYRLKNMEIKDPSVRFCYNMLNRVSRSFAMVIQQLPVELRDATCVFYLILRALDTVEDDMAIPKEVKIPMLRTFHEHLSDRSWKIKCGYGPYVDLMDNYPLVTDVYLRFDEGTKAVIKDITRRMGNGMADFIDLDEVLTIPQYDLYCHYVAGLCGIGMCKLFVDSGLEKEDLVAEEDLANQMGLFLQKNNIVRDYLEDINELPAPRMFWPKEIWGNYAKQLDEFKDPKNLDKAMLCLNHMVTDALRHCEVGLRSLSLLHNPNILRAVLIPQVMGVRTLTLVYNNPEVFRGVVKMRRGETAKIFVTTTSKLSFFRTYLQFANEMEQKCLTEAKNDPMVALTLKRVQGVQAACRAAIVKAEIAEGAKGPSTAMVLAGALLIAALAYFAYVYSAGGTSLKALPLFGVVIILAIGLFGRNLALKTV
Protein: Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 (EC 2.7.12.1) (Dual specificity Yak1-related kinase mbk-2) (Minibrain Kinase 2) (Q9XTF3)
Organism: Caenorhabditis elegans
Function: Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Through phosphorylation of P granule components including meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm during zygote polarization, and thus plays a role in P granule distribution and segregation in early stage embryos following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:12618396, ECO:0000269|PubMed:16338136, ECO:0000269|PubMed:17869113, ECO:0000269|PubMed:18854162}. Note=Maintained at the cortex by the cortical anchor egg-3 before meiotic divisions. During anaphase of meiosis I, egg-3 translocates into the cytoplasm on vesicles and is slowly degraded, releasing mbk-2. {ECO:0000269|PubMed:12618396, ECO:0000269|PubMed:16338136, ECO:0000269|PubMed:17869113, ECO:0000269|PubMed:19879842}.
Interaction partners:
- Protein tyrosine phosphatase-like protein egg-3
- Inactive protein-tyrosine phosphatase egg-4
- CCCH-type zinc finger protein oma-1
- Meiotic spindle formation protein mei-1
- Uncharacterized protein
- Inactive protein-tyrosine phosphatase egg-5
- Chitin synthase chs-1
- Zinc finger protein mex-5
- WD_REPEATS_REGION domain-containing protein
- CCCH-type zinc finger protein oma-2
Sequence:
MAALASFTRNSRSYGQQPIDVTQQGQRDRSVMSLDAQGRSVSHECPTSTTLVRQLYLPQIPQSASFAAAPTSFSGASSSSSNHHHPVYHSQNSLPPNLLGSSQNSASSNSLVQGHRNPALGSGNTLTRSYHQPSSTNSSTNNLYGPLGTISRDLKQSIRDISPPVINSSANPHLVNYVQTSSFDNGSYEFPSGQAQQQRRLGGSQQHLAPLQQTASSLYSNPQSSSSQLLGQQQAVRPNYAYQQSLPRQQHINSHQTQAFFGTVRGPTNSTNIVTPLRASKTMIDVLAPVRDTVAAQATGLPNVGTSSSNGSSNSSSGVGSGGSGSLMTQSIGGPNKHLSASHSTLNTASTHDMMHSKIPKSPSNESLSRSHTSSSGGSQGGHNSNSGSNSGFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLADHEKKTETLPNIDSNANILMRKKF
Protein: Mitochondrial outer membrane import complex protein METAXIN (O64471)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in transport of proteins into the mitochondrion.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The inner membrane localization is based on mass spectrometry identification and may be the result of sample contamination. {ECO:0000269|PubMed:14730085, ECO:0000269|PubMed:17981999}.
Interaction partners:
- Mitochondrial import receptor subunit TOM40-1
- Outer membrane OMP85 family protein
- Outer membrane OMP85 family protein
- Outer envelope protein 36
- Outer envelope protein 39
- Probable mitochondrial import receptor subunit TOM40-2
- Mitochondrial import receptor subunit TOM9-1
- DUF630 family protein
- GDSL esterase/lipase At2g19060
- At2g19160
Sequence:
MEGDQETNVYTLVARKPSFDLPTACPNCLPAYIYLKLAQLPFELAFNSTFPDSDELPYFESDTYVAYNNEDGGVIEKLKKDGIVNLDSQLQSLSDYLSLKALIVSWLEEALTYEIWVGTEGISTSKIYYSDLPWVISKVLFYKQTYLAKNRLGITKENAEQREKQIYKRASEAYEALSTRLGEQKFLFEDRPSSLDAFLLSHILFIIQALPVTSVLRCKLLEHSNLVRYAEKLKSEFLEASSSSPSPPLHSFPSSFPRKSSKPKSKPKVEKTEEEKKFKKRARFFLAAQFLAVVIYVSVMGGGSSDELEYEDEDD
Protein: Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11) (Q8NBW4)
Organism: Homo sapiens (Human)
Function: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (Probable). However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906, ECO:0000269|PubMed:29053970, ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}. Late endosome membrane {ECO:0000269|PubMed:25561175}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}.
Interaction partners:
- Ragulator complex protein LAMTOR5
- Ragulator complex protein LAMTOR3
- Ragulator complex protein LAMTOR1
- Ras-related GTP-binding protein C
- Ras-related GTP-binding protein B
- Ragulator complex protein LAMTOR2
- Ras-related GTP-binding protein A
- Ragulator complex protein LAMTOR4
- Ras-related GTP-binding protein D
- NPC intracellular cholesterol transporter 1
Sequence:
MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEPTNIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYCCYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWWDKSRTVPFYLVGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHLEFHWFIPTEFFVPEIRFQFPQLTGVLTLAFFIHNCIITLLKNNKKQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLIFHVFIIILGVANLIVQFFM
Protein: Insulin-like growth factor-binding protein 3 (Q66I28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Insulin-like growth factor-binding protein complex acid labile subunit
- Insulin-like growth factor 2a.
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Zgc:158398.
- Insulin
- Insulin
Sequence:
MTGLCALCLTALLAAFARLAESVSPVVRCEPCDDGAMVLCKPLPWDCDEPVKEPGCGCCLTCPLTEGQACGVYTGRCGTGLSCQHRPGESKPLQALLEGRGVCAKAPDKKQSGSPSHGHDKPETEGKEQNGTRTAGTGEAETVHHTTDISRDVQGGSRTPSEPSDPMMHSNKLEMIQKEQVKKSQVHKVVPFSGWIVQDIHNFSLESKRENEYGPCRREMESVMKQLKFTNVLNPRRFRIPNCDQKGFYKKKQCSPSKGRKRGHCWCVDKYGQPLPGYDGKEKVHCYNMETK