wanglab/gogpt-training-data huggingface dataset:
Protein: Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog) (A8DYE2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Calcium channel mediating constitutive calcium ion entry.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Inactive
- SD02261p
- MIP30126p
- Transient receptor potential cation channel subfamily A member 1
- No mechanoreceptor potential C, isoform H
- Ankyrin 2, isoform U
- Ankyrin, isoform B
- Nudix hydrolase domain-containing protein
- Inositol 1,4,5-trisphosphate receptor
- Transient-receptor-potential-like protein
Sequence:
MVVTDSPLAPHKYVRRISKDFSTVRRYSNTPAVVVGSFRASTSAFIAAESAAHLPTCSSPTTRTPVSTPRGIRRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVDGDLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQLKNERPWQRNSSMEQQTYPSPLVPTRATSDFLNPPYEGRLFKKSSESLQKNSSTETDYSAHPYRFIKQSSNETNTSLTGSYNVDTPSLTAEPSLDAGDSHSATGISISVGAVGGTATARYQPIRTASVGAADGRRLREESSSSLDLSSSGPVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTAAEAVPQTPEAAQAGQAKLISTLKPQPFASKLGMNVLKESSSSTDESVGSSAKSSNPALSIPQISTHLVQDEIAKLSSNIKSSTESEKDPPFNETMC
Protein: Kinesin-like protein (A0A2U3TZL8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MKSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGYRLNRNGDYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGLLPRCLDMIFNSIGSFQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMPNPKTSSSKRQVDPEFADMITVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVPFDPIKPKWNSCSTPMRNTDFVPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREAGNINQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEENLQVMRFAEVTQEVEVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPLPSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKENHMQGKLNEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECLLFQPDQNAPPIRLRHRRSRSAGDRWVDHKPASNMQTETVMQPHVPHAITVSVANEKALAKCEKYMLTHQELASDGEIETKLIKGDIYKTRGGGQSVQFTDIETLKQESPNGSRKRRSSTVAPAQPDGAESEWTDVETRCSVAVEMRAGSQLGPGYQHHAQPKRKKP
Protein: Protein TONSOKU (CuTSK) (A0A2H5Q1B8)
Organism: Citrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu)
Function: Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (By similarity). Specifically recognizes and binds histone H3.1 lacking methylation at 'Lys-27' (H3K27me1).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6Q4D0}. Chromosome {ECO:0000250|UniProtKB:Q6Q4D0}.
Interaction partners:
Sequence:
MGRDEMQMSEAKRAYRSAKEEGNRQEEARWANVIGDILKNRGEYVEALKWFRIDYDVSVKYLPEKHLLPTCQSLGEVYLRLEHFKDALIYQKKHLELAKDASDLVEQQRACTQLGRTYYEMFLRSDDDHYSIRNAKKYFKSAMKLAQTLKENPATSRSSFLKEYIDAHNNIGMLQMELDNLEEAKKLLIRGLEICNEEEVSEDDDGRSRLHHNLGNVYMELRMWDKSREHIEQDIIICKKIEHRQGEAKGYINLGELHYRVQKYDEAILCYQKALNLAQSMEDEDALASQIDQNIETVKKAIEVMDELKKEEQNLKKLTRNMIIAKGTSQERKSLLQQNASLDCLIEKSSMIFAWLKHCEYAKRKKRIASELCDKGKLSDSFLVIGESYQKLRKFNKAIKWYTKSWEMYKSIGNLEGQALAKVNMGNVLDSNGDWAGALDAFQEGYRIAVEANLPSVQLSALENMHYSHMIRFDNIEEARRLQHEIDKLKESKSEDLEAYDVAKDCCSETDTEGNDHLPDVRSSACFSAEMSKSDSGRSKTLAGLEEVEDDEPLISFLRSSERLPKLKRAYVEKQNIPTEPRELTPKTLSKSTNSQQTGGGRKRIRVVLSDDEGDIDNEEGLKGRLQKCPVEGVATFDASRWFILLVWQDVPAADFKCTNSSENPINVEESTCSHKFTSSNPTNQYGNAIRCTGKVFIASDVNDDQCVTFRIDDDLIQLEVHSCICDDKLDIESLKVELACLYYLQLPKEKISKGLLPIIQHMKYGGRSLESFDAFKDQLGKDIIEVSIDGWVQKRLMKLYIECCKELSEAPNMKLLKKLYISEVEDEVVVSECELQDISVTPLLNALQTHKTVAMLDLSHNLLGNGTMEKLQQFFISSCQNYVDLTLDLHCNRFGPTTLFQICECPVLFTRLGVLNLSGNRLTDACGSYLSTILKNCKVLYSLNIENCSITSRTIQKVADALGAESTLAQLCIGYNSPVTGNAITNLLVKLDTLKSFSELNLNGLKLSKPVVDRLCQLAKTSCLTHLMLGCTNLGSDGSLQLVESLFSRAQESVKLDLSYCGLESTCIHKFTASVSLVHGILELNLGGNPIMKEGANALASLLMNPQCCLKVLVLSKCQLGLAGVLQLIKALSENDTLEELNLADNASKELTLQQNLSSVNSENLQPALKTSDGVSKEVDTDQQGLCAMNTDCNDLEVADSEDDKIRVESAASGFDNSCTSSCQKNSSFECQFIQELSSAIGMAKPLQLLDLSNNGFSTQAVKTLYSAWSSRSGAGPTWKHIKEQIIHFSVEGNKCCRVKPCCRKN
Protein: Catenin beta-1 (Beta-catenin) (P26233)
Organism: Xenopus laevis (African clawed frog)
Function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome. In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorsoventral patterning: in prospective ventral blastomeres, its down-regulation by axin1 and axin2 leads to inhibit the Wnt signaling pathway, while in prospective dorsal blastomeres, degradation of axin results in stabilization and nuclear translocation of ctnnb1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P35222}. Nucleus {ECO:0000269|PubMed:25157132}. Cell membrane {ECO:0000250|UniProtKB:F1QGH7}. Note=Cytoplasmic when it is un-stable (highly phosphorylated). Translocates to the nucleus when it is stabilized (low level of phosphorylation). The majority of beta-catenin is localized to the cell membrane (By similarity). Reduced nuclear localization seen in the presence of custos (PubMed:25157132). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000250|UniProtKB:P35222, ECO:0000269|PubMed:25157132}.
Interaction partners:
Sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDEDVDTNQVLYEWEQGFSQSFTQDQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYSYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSIGGTQQQFVEGVRMEEIVEGCTGALHILARDIHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCDVAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMPWNEAADLGLDIGAQGEPLGYRQDDSSYRSFHAAGYGQDAMGMDSMMDHDMGGHHPGADYPVDGLPDLSHAQDLMDGLPPGDSNQLAWFDTDL
Protein: Hexanoyl-CoA synthase (EC 6.2.1.-) (Acyl-activating enzyme 1) (CsAAE1) (H9A1V3)
Organism: Cannabis sativa (Hemp) (Marijuana)
Function: Involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity. Acyl-activating enzyme that catalyzes the conversion of hexanoic acid to hexanoyl-CoA, precursor of the cannabinoid pathway. Can also activate other fatty acids including heptanoate, octanoate and nonanoate.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22353623}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGKNYKSLDSVVASDFIALGITSEVAETLHGRLAEIVCNYGAATPQTWINIANHILSPDLPFSLHQMLFYGCYKDFGPAPPAWIPDPEKVKSTNLGALLEKRGKEFLGVKYKDPISSFSHFQEFSVRNPEVYWRTVLMDEMKISFSKDPECILRRDDINNPGGSEWLPGGYLNSAKNCLNVNSNKKLNDTMIVWRDEGNDDLPLNKLTLDQLRKRVWLVGYALEEMGLEKGCAIAIDMPMHVDAVVIYLAIVLAGYVVVSIADSFSAPEISTRLRLSKAKAIFTQDHIIRGKKRIPLYSRVVEAKSPMAIVIPCSGSNIGAELRDGDISWDYFLERAKEFKNCEFTAREQPVDAYTNILFSSGTTGEPKAIPWTQATPLKAAADGWSHLDIRKGDVIVWPTNLGWMMGPWLVYASLLNGASIALYNGSPLVSGFAKFVQDAKVTMLGVVPSIVRSWKSTNCVSGYDWSTIRCFSSSGEASNVDEYLWLMGRANYKPVIEMCGGTEIGGAFSAGSFLQAQSLSSFSSQCMGCTLYILDKNGYPMPKNKPGIGELALGPVMFGASKTLLNGNHHDVYFKGMPTLNGEVLRRHGDIFELTSNGYYHAHGRADDTMNIGGIKISSIEIERVCNEVDDRVFETTAIGVPPLGGGPEQLVIFFVLKDSNDTTIDLNQLRLSFNLGLQKKLNPLFKVTRVVPLSSLPRTATNKIMRRVLRQQFSHFE
Protein: Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p19ARF) (Q8QZZ9)
Organism: Rattus norvegicus (Rat)
Function: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N726}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8N726}.
Interaction partners:
- cyclin-dependent kinase
- Cyclin-dependent kinase 4
- E3 ubiquitin-protein ligase Mdm2
- Nucleophosmin
- Cellular tumor antigen p53
- Cyclin-dependent kinase 4 inhibitor B
- Receptor protein-tyrosine kinase
- Cyclin-dependent kinase 2
- Myc proto-oncogene protein
- Cyclin-dependent kinase inhibitor 1
Sequence:
MGRRFVVTVRIRRTGRSPQVRVFLVQFLGSSRPRSANGTRGFVALVLRPERIARRGPQPHPGPGDDDGQRQSGSSPALLWCRFELRGPHHPLPTGARRSAGGLPRHSGSTAPGRGAAGCARCLGSPAARPGPRAGTSRRRAVFAVSTLLRWERFPGHRQA
Protein: Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform) (A0A060W3E5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Troponin C, skeletal muscle
- Troponin C, skeletal muscle
- Troponin C, skeletal muscle
- Uncharacterized protein
- Troponin T type 3a
- Uncharacterized protein
- Troponin T type 2b
- Troponin T2e, cardiac
- Troponin T, slow skeletal muscle
- Troponin T, slow skeletal muscle
Sequence:
MSEKKMSSSRRHYLKSLMLSIAKGLLEEEAKENEQERIRWMEENCPPLSLPGGTQQLMEFLKELHHKIDVIDEERYDLENKVNKSTKEIEDLNIKVIDLKGKFKKPTLRKVRMSADAMLQALLGSKHKVSMDLRANLKQVKKEVKEEDKELRNVGDWRQNIEDKSGMDGRKKMFESES
Protein: Uncharacterized protein YDL211C (Q12121)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Vacuole membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YDR476C
- F-actin-capping protein subunit alpha
Sequence:
MLLNVTSSQYISTPQSRSLSEIDTSETASLSSATDHIFALSTEVVSSITTNLIEGLESSIQVPISTAYGTTSFRNNTSSPQYLVSNCTSSVQSNITIDRGLLSTLKTFTTSQVPTIEPSTTKLTTPLSTTFTSTSTSEIYSVFTSENSVYIIYDQEYKFTERSTTFNTHFPQTTVLQESNPPLTFTIPSNTITGDAKLYQYLSGALNTQDTSDANNRRTGVIVGSTVGVVIGVVIVIFIGFIIIRNRRNVKNHSKKGFSHDIGKRVSCDEVTETEAPSNPFLNVLNYKVTTNGEGKRDSFENGRDLHRASSSDGIYIAHPYYGMADHESGRFSYVSSYNESAESSIEETSSSASTITRPNIQQTNSFLREII
Protein: Secreted protein (P96854)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTRLIPGCTLVGLMLTLLPAPTSAAGSNTATTLFPVDEVTQLETHTFLDCHPNGSCDFVAGANLRTPDGPTGFPPGLWARQTTEIRSTNRLAYLDAHATSQFERVMKAGGSDVITTVYFGEGPPDKYQTTGVIDSTNWSTGQPMTDVNVIVCTHMQVVYPGVNLTSPSTCAQANFS
Protein: RalA-binding protein 1-A (RalBP1-A) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein) (Ral-interacting protein 1-A) (RIP1-A) (XRLIP2) (XRLIP76-A) (Q9PT60)
Organism: Xenopus laevis (African clawed frog)
Function: Multifunctional protein that functions as a downstream effector of ralA and ralB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of ralA. Recruited to mitochondrion by ralA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity). Acts on the cytoskeleton, to regulate pigment distribution and to regulate gastrulation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15511640}; Peripheral membrane protein {ECO:0000269|PubMed:15511640}. Cytoplasm, cytosol {ECO:0000269|PubMed:15511640, ECO:0000269|PubMed:22319010}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q62796}. Nucleus {ECO:0000269|PubMed:22319010}. Mitochondrion {ECO:0000250|UniProtKB:Q15311}. Note=Targeted to the plasma membrane through its interaction with ralB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (PubMed:15511640). Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010). {ECO:0000269|PubMed:15511640, ECO:0000269|PubMed:22319010}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:22319010}. Cell projection, lamellipodium {ECO:0000269|PubMed:22319010}.
Interaction partners:
Sequence:
MTECFLPPASSPSEHRRAEHGGGLARTPSSEEISPTKFPGLYRTGEPLPPHDILHEPPDIVSEDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKIKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEDKHKEKKSKDLTAADVVKQWKEKKKKKKPTPEPESLPVDIPRLRPVFGIPLIEAAERTMIYDGIRLPLVFRECIDFIEQHGMKCEGIYRVSGIKSKVDELKAAYDREESPNLEDYEPYTVASLLKQYLRELPENVLTKDLMPRFEEACGKTTEGERLQECQRLLKELPECNFCLTSWLVVHMDHVIEQELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGGVQIKRVIKPLRWSNMATMPALPETQETIKEEIRRQEFLLNCLHRELQAGVKDLSKEERLWEVQRILTALKRKLREAKRQDCETKIAQEIASLSKEDVSKEEMTENEEEVLNILLAQENEILTEQEELVAMEQYLRRQIATEKEEIDRLRAEISEIQSRQQHGRSETEEYSSESESESEDEEELQYILEDLQRQNEELEIKNTHLNQAIHEEREAIIELRVQLRLLQKQRVKSEQLQEEEELGKQNVPSQLPRDNLPETKAPKDQPKALMEQMKPSPIKKTGKKLSSETLI
Protein: Cytochrome P450 77A4 (EC 1.14.-.-) (Fatty acid epoxidase) (Q9LZ31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the epoxidation of physiological unsaturated fatty acids in vitro. Can use laurate, oleate, linoleate, linolenate and vernolate as substrate.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome P450 704B1
- Protein HOTHEAD
- Omega-hydroxypalmitate O-feruloyl transferase
- Fatty alcohol:caffeoyl-CoA acyltransferase
- F21B7.2
- RING-type E3 ubiquitin transferase
- Cytochrome P450 86A1
- Cytochrome P450 86B1
- Cytochrome P450 86A8
- Cytochrome P450 86A2
Sequence:
MFPLISFSPTSLDFTFFAIIISGFVFIITRWNSNSKKRLNLPPGPPGWPVVGNLFQFARSGKPFFEYAEDLKKTYGPIFTLRMGTRTMIILSDATLVHEALIQRGALFASRPAENPTRTIFSCNKFTVNAAKYGPVWRSLRRNMVQNMLSSTRLKEFGKLRQSAMDKLIERIKSEARDNDGLIWVLKNARFAAFCILLEMCFGIEMDEETIEKMDEILKTVLMTVDPRIDDYLPILAPFFSKERKRALEVRREQVDYVVGVIERRRRAIQNPGSDKTASSFSYLDTLFDLKIEGRKTTPSNEELVTLCSEFLNGGTDTTGTAIEWGIAQLIANPEIQSRLYDEIKSTVGDDRRVDEKDVDKMVFLQAFVKELLRKHPPTYFSLTHAVMETTTLAGYDIPAGVNVEVYLPGISEDPRIWNNPKKFDPDRFMLGKEDADITGISGVKMIPFGVGRRICPGLAMATIHVHLMLARMVQEFEWCAHPPGSEIDFAGKLEFTVVMKNPLRAMVKPRI
Protein: Zinc finger MYM-type containing 3 (A6NHN7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPERVQKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSAVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDPADATRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPESKPQTPSQTKVENSNTVRTPEENGNLGKIPVKTRSAPTAPTPPPPPPPATPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRTMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKAKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTGPGKRKREDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD
Protein: Zinc finger imprinted 3 (Zinc finger protein 657) (Q96PE6)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 716
- Ubiquitin carboxyl-terminal hydrolase 29
Sequence:
MNNSQGRVTFEDVTVNFTQGEWQRLNPEQRNLYRDVMLENYSNLVSVGQGETTKPDVILRLEQGKEPWLEEEEVLGSGRAEKNGDIGGQIWKPKDVKESLAREVPSINKETLTTQKGVECDGSKKILPLGIDDVSSLQHYVQNNSHDDNGYRKLVGNNPSKFVGQQLKCNACRKLFSSKSRLQSHLRRHACQKPFECHSCGRAFGEKWKLDKHQKTHAEERPYKCENCGNAYKQKSNLFQHQKMHTKEKPYQCKTCGKAFSWKSSCINHEKIHNAKKSYQCNECEKSFRQNSTLIQHKKVHTGQKPFQCTDCGKAFIYKSDLVKHQRIHTGEKPYKCSICEKAFSQKSNVIDHEKIHTGKRAYECDLCGNTFIQKKNLIQHKKIHTGEKPYECNRCGKAFFQKSNLHSHQKTHSGERTYRCSECGKTFIRKLNLSLHKKTHTGQKPYGCSECGKAFADRSYLVRHQKRIHSR
Protein: Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) (Q91018)
Organism: Gallus gallus (Chicken)
Function: Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Lymphatic vessel endothelial hyaluronan receptor 1
- Vascular endothelial growth factor C
Sequence:
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKPNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDVCSNSSRDSPQECLSPFGRPTMSQFDVDRLCDEHLRAKRARVENIIRGMSHSPRVALRGNENEREIRPQSVSPRESYRENKRKQNWPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEEFYQIYDSTDSENDEDGNLSEDRMRSETVDAQAGDSVGRSDNEMCELDPGQFIDRARALIREQEIGENKPKREGPKEKDQGPNSFHPEGKHLAETLKQELNTAMSQVVDTVVKVFSSKPSRQLPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFSSVPMPGATDQTDALPLVVRKNSSDQPASAPPAGGHHASLHQSPLSATAGFSTSSFRHPFPLPLMAYPFQSPLGAPSASFPGKERASPESLDLTRETTSLRTKMSSHHMNHHPCSPAHPPSAAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
Protein: At1g43860 (F28H19.11 protein) (Sequence-specific DNA binding transcription factor) (Q9MAR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Large ribosomal subunit protein eL43y
- Large ribosomal subunit protein eL43z
- Large ribosomal subunit protein uL5y/uL5x/uL5w
- Large ribosomal subunit protein uL5z
- Large ribosomal subunit protein eL24z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL5c
- Large ribosomal subunit protein eL24y
- Ubiquitin-ribosomal protein eL40y fusion protein
- Large ribosomal subunit protein uL30z
Sequence:
MSKTLVQPVGQKRLTNVAVVRLKKQGNRFEIACYKNKVLSWRSGVEKDIDEVLQSHTVYSNVSKGVLAKSKDLMKSFGSDDHTKICIDILEKGELQVAGKERESQFSSQFRDIATIVMQKTINPETQRPYTISMVERLMHEIHFAVDPHSNSKKQALDVIRELQKHFPIKRSPMRLRLTVPVQNFPSLLEKLKEWDGSVVSKDESGTQMSTVCEMEPGLFRECDSHVRSIQGRLEILAVSVHAEGDTSMDHYDEHDDMALQTHKPLLPAETETKDLTDPVVELSKKLQKQEISTTDNIKQEGGEEKKGTKCSTCNTFVGEAKQYREHCKSDWHKHNLKRKTRKLPPISADECMSEIDMDDSRADLKDYSF
Protein: Transmembrane protein 51 (Q9NW97)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSAAEKPTAQGSNKTEVGGGILKSKTFSVAYVLVGAGVMLLLLSICLSIRDKRKQRQGEDLAHVQHPTGAGPHAQEEDSQEEEEEDEEAASRYYVPSYEEVMNTNYSEARGEEQNPRLSISLPSYESLTGLDETTPTSTRADVEASPGNPPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRINLPDKNVPPPSIEPLTPPPQYDEVQEKAPDTRPPD
Protein: Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Q8R2Q4)
Organism: Mus musculus (Mouse)
Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03059}.
Interaction partners:
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL20m
- Ribosome-recycling factor, mitochondrial
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL32m
Sequence:
MFTKWRIFAVNHQRTFSVHLNTMCYCKIKANLKRLKTQLPLTRNYSSAPGIAGSDVKSLHSVINPPVAKIRNIGIMAHIDAGKTTTTERILYYSGYTRSLGDVDDGDTVTDFMAQERERGITIQSAAVTLDWKGYRVNLIDTPGHVDFTLEVERCLRVLDGAVAVFDASAGVEAQTLTVWRQADKHKIPRICFLNKMDKTGASFNYAVESIREKLKAKPLILQLPIGEARTFQGVVDVVNKEKLLWNSNSDDGKDFERMPLSEASDRELLKETIEARNSLIEQVADLDDEFADLVLGEFSENFDLVPAEKLQAAVHRVTLAQAAVPVLCGSALKNKGVQPLLDAVTTYLPSPEEREDRFLQWYEGDLCALAFKVLHDKQRGPLVFLRIYSGTLTPQLAVHNINRNCTERMSRLLLPFADQHVEIPSLTAGNIALTVGLKQTATGDTIVSSKSSALAAARRAGRGEREHGKKREAESLLLAGVEVPEPVFFCTIEPPSVAKQPDLDHALERLQREDPSLKVKLDPDSGQTVLCGMGELHIEIIHDRIKREYGLETYLGPLQVAYRETILNSVRATDTLDRVLGDKRHLVSAELEVRPAEEPCAVAKIEYADCVGEDLLQASREAIESAVHSACLQGPLLGSPVQDVAMTLHSLMIHPGTSTTMVTACISRCMQKALKKADKQVLEPLMSLEVTVSREYLSPVLADLAQRRGNIQEIQTRQDNRVVLGFVPLAEIMGYSTVLRTLTSGSATFALELSTYQAMSPQDQSALLNQRSGLAHVL
Protein: Rifin (Q8IM82)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKDHYINILLFALPLNILVYNQRNYYITPRHTETNRSLCECELYSPTNYDSDPEMKRVMQQFVDRTTQRFHEYDESLQSKRKQCKDQCDKEIQKIILKDKIEKEFTEKLSTLQTDITTKDIPTCVCEKSLADKMEKVCLKCAQNLGGIVAPSTGVLGEIAALAVNAWKTTALKNAIAAAQKAGDAAGKIAGESKGVETIIGILEQYYSIYELKGTPLKSFFATTHYTDISNIATVIDTELNTSCGLNSLANQAICGLRTKLGLVAKPGQVMVTQKEAITKMITNVVHKSEITAEAAKTEVAATKTAAAIKMNTEAIEAATTPYYTPIIASIVAIVVIVLIMVIIYLILRYRRKKKMKKKLQYIKLLN