wanglab/gogpt-training-data huggingface dataset:
Protein: 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL) (Q8TB92)
Organism: Homo sapiens (Human)
Function: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22847177}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22847177}; Peripheral membrane protein.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Methylglutaconyl-CoA hydratase, mitochondrial
- Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase, cytosolic
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, peroxisomal
- D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Sequence:
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
Protein: Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) (P08414)
Organism: Mus musculus (Mouse)
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). May be involved in spermatogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10932193}. Nucleus {ECO:0000269|PubMed:10932193}. Note=Localized in hippocampal neuron nuclei (By similarity). In spermatids, associated with chromatin and nuclear matrix. {ECO:0000250}.
Interaction partners:
- Calmodulin-like protein 4
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 3
- Calmodulin-1
- Cyclic AMP-responsive element-binding protein 1
- Calcium/calmodulin-dependent protein kinase kinase 1
- Histone deacetylase 4
- Calcium/calmodulin-dependent protein kinase kinase 2
- Histone lysine acetyltransferase CREBBP
Sequence:
MLKVTVPSCPSSPCSSVTASTENLVPDYWIDGSNRDPLGDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTSIQENHKASSDPPSTQDAKDSTDLLGKKMQEEDQEEDQVEAEASADEMRKLQSEEVEKDAGVKEEETSSMVPQDPEDELETDDPEMKRDSEEKLKSVEEEMDPMTEEEAPDAGLGVPQQDAIQPEY
Protein: Rho GTPase activating protein 4 (Q8K4G7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTQGYLAWASLQTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMATPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV
Protein: Erythritol kinase (EC 2.7.1.215) (Q2YIQ1)
Organism: Brucella abortus (strain 2308)
Function: Catalyzes the phosphorylation of erythritol to D-erythritol-1-phosphate.
Interaction partners:
- D-erythrulose 1-phosphate 3-epimerase
- Erythritol catabolism regulatory protein EryD
- D-erythritol 1-phosphate dehydrogenase
- D-erythrulose-4-phosphate isomerase
- L-erythrulose-1-phosphate isomerase
- L-rhamnose mutarotase
- Bacterial regulatory protein, DeoR family
- Transposase
- DUF2291 domain-containing protein
- Periplasmic binding protein/LacI transcriptional regulator
Sequence:
MSAMREKGDIIIGIDAGTSVLKAVAFDFSGRQIESAAVRNTYVTGDHGAVTQSLAQTWQDCARALRDLGAKLPGLAQRTAAIAVTGQGDGTWLVGKDNRPVGDAWIWLDARAASTVTRLAAGPMNRARFEATGTGLNTCQQGAQMAHMDTIAPELLDNAEAALHCKDWLYLNLTGVRATDPSEASFTFGNFRTRQYDDVVIEALGLQKRRNLLPEIIDGSQSQHPLSAEAAAATGLLAGTPVSLGYVDMAMTALGAGVCGGTAGAGCSTIGSTGVHMRAKPVADIHLNKEGTGYVIALPIPGIVTQVQTNMGATINIDWILQVAADLMSTPEKPVSLGDLIPRLDDWFNASRPGAILYHPYISEAGERGPFVNANARAGFIGLSSRDRFPELVRSVVEGLGMATRDCYAAMGEMPAELRITGGAARSKALRGTLSAAVNAPVRVSAREEAGAAGAAMMAAVAIGAYPAMDDCIAEWVEPLLGASEAPDAARAHQYEELFVAYREARLALAPVWDKLASGK
Protein: ATP-dependent RNA helicase, DEAD/DEAH family (Q9A6P4)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Phosphoesterase
- DNA ligase
- Metallo-beta-lactamase domain-containing protein
Sequence:
MLAANALPPQFQAWFAKRGWTPRDHQLAMLDKARAGRGALLIAPTGGGKTLAGFLPSLIELAERPPRNTPAGVHTLYISPLKALAVDVERNLLTPIREMGLPIVAESRTGDTGESRKARQKVRPPDILLTTPEQLALFCAWEGAREYFSDLRCVIIDEAHAIWPSKRGDLLALGLSRLQQFAPNMRRVGLSATVDDPDLVRKWLGVNRVENPPPRAGEVSAEPTEGASTADLQLALSGPPGHLPRAQGRICEPDIDLVLGAGGAQPVVEVLVSGGRVPWAGHTAEHAMAEVYDIIKAAKTALVFVNTRFQAEFAFQRLWELNDEGLPIALHHGSLSAEQRRKVEAAMARGELRAVVCTSTLDMGIDWGDVDLVIQLAAPKGASRMVQRIGRANHRLDEPSRAIFVPASRFEMLECRAAADAILENHLDGEPPRTGALDVLAQHIMGCACSEPFKPTDLYDEVRSAGPYAELTWEDFEAVVDFVSTGGYALRTYDKFRRIVQIADGLRTARNAQARQQHRMNVGAIISPAMINIRIGGGRKPVGGRKIGEAEEGYFEQLTPGDTFVFAGQVWRYNSLVGADAYVSPAPNDDPKMPSWGGSKFPLSTYLAERVRQMMHDEREWSALPGDVQEWLSWQKIRSAIPAEGEMLLETFPRGKRFHMVCYPFDGRLAHTTLAMLLTRRLDRLGVGPLGFVCNDYALNLWSLRPMDDLDLDELFAQDMLGDDLEAWLDESFMMKRSFKHCALIAGLIERRHPGAEKSGRQVTFSTDLIYDVLRKHQPDHLMLRCARLDAATGLLDIARLGDMLTRVRGRIRHVALDRVSPFAVPMMLEIGRERAPGDAAGEMILAEAEADLIAEARP
Protein: Protein SSX7 (Q7RTT5)
Organism: Homo sapiens (Human)
Function: Could act as a modulator of transcription.
Interaction partners:
- Protein SSX3
Sequence:
MNGDDAFARRPRAGAQIPEKIQKSFDDIAKYFSKKEWEKMKSLEKISYVYMKRKYEAMTKLGFKATLPPFMHNTGATDLQGNDFDNDRNQGNQVERPQMTFCRLQRIFPKIMPKKPAEEGNDSKGVPEASGSQNDGKHLCPPGKPSTSEKINKTSGPKRGKHAWTHRLRERKQLVIYEEISDPEEDDE
Protein: D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Ketose 1,6-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase) (P0AB74)
Organism: Escherichia coli (strain K12)
Function: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability.
Interaction partners:
- D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- Putative D-galactosamine-6-phosphate deaminase AgaS
- ATP-dependent 6-phosphofructokinase isozyme 1
- D-tagatose-1,6-bisphosphate aldolase subunit GatZ
- ATP-dependent 6-phosphofructokinase isozyme 2
- Putative deaminase AgaI
- L-threonate dehydrogenase
- 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
- D-tagatose-1,6-bisphosphate aldolase subunit GatY
- N-acetylgalactosamine permease IIC component 1
Sequence:
MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA
Protein: Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta) (Q86UW2)
Organism: Homo sapiens (Human)
Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Modulates SLC51A glycosylation, membrane trafficking and stability activities. The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols. Able to transport eicosanoids such as prostaglandin E2 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}; Single-pass membrane protein {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
Interaction partners:
- Organic solute transporter subunit alpha
- Cytochrome P450 7A1
- Ileal sodium/bile acid cotransporter
- ATP-binding cassette sub-family C member 3
- Bile acid receptor
- Bile salt export pump
- Hepatic sodium/bile acid cotransporter
- Gastrotropin
- Nuclear receptor subfamily 0 group B member 2
- 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Sequence:
MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFLPDVPETES
Protein: Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)] (P57774)
Organism: Mus musculus (Mouse)
Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
Interaction partners:
- Neuropeptide Y receptor type 1
- Neuropeptide Y receptor type 2
- Neuropeptide Y receptor type 5
- Pancreatic polypeptide prohormone
- Peptide YY
- Pro-opiomelanocortin
- Somatostatin
- Agouti-related protein
- Appetite-regulating hormone
- Leptin
Sequence:
MLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENAPRTRLEDPSMW
Protein: Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) (P16220)
Organism: Homo sapiens (Human)
Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12552083}.
Interaction partners:
- CREB-binding protein
- CREB-regulated transcription coactivator 2
- Histone acetyltransferase p300
- Protein c-Fos
- CREB-regulated transcription coactivator 1
- Cellular tumor antigen p53
- Transcription factor Jun
- Transcription initiation factor TFIID subunit 4
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- cAMP-dependent protein kinase catalytic subunit alpha
Sequence:
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Protein: At1g08760 (F22O13.25) (GPI-anchored adhesin-like protein, putative (DUF936)) (Q9FRR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANLVPGVLLKLLQHMNTDVKIAGEHRSSLLQVISIVPALAGGELFPNQGFYLKVSDSSHATYVSLPDEHDDLILSDKIQLGQYIHVDRVESSSPVPILRGVRPVPGRHPCVGDPEDIVATHSLGFLSDDKVKNDNNGGVSSKPKERVKASVKANGSGSDGERIIGNRLSVSISRDDSSDGKKPVSALFRAKSAKSSLSLDVKKESLGKLKTSSGSKSIPSSPTSCYSLPNSFAKFANGIKQQQTVKPKLLEKGSPRMGLSEKGRSLLKAESPKVGKKLPMIKNFVQGIEFGAKALRKSWEGNLDIRGSDRTKSSLPRRDLTPDSRSLAAPRRSTSSEKLPSKQERANVFARSSKEHNKIQSTKKVEPTAVLDTKDKTSRPKSTSVEKKSVAENGLPGNLVKVSVNGKRLAAANIQWSSLPPSLSRMGQEVLRHREAAQVVAIEALQEASASESLLQCLIMYSDLLSTAKEDDPLPVVEQFLKLHSGLKNVQVITESLSKLLSLMSSPDNEENRSEEAIKAASEKQKLAASWVQAALVTNLSPFSVYSSKQAKLAASRSKPVIILESPGNNSSSKTRGNIQNKPTIGSKLVAQGMIRKHRENSSSQKATSVAGSESPPLNWVKGNGLNEATDLAEKLQMVSQDWFLGFVERFLDADVITSSSLSLSDNGQIAGMLSQLKSVNDWLDEIGSKEDEEGLQEVSKETIDRLRKKIYEYLLTHVESAAAALGGGGGSVSSPRPKPIETKAKR
Protein: Fibronectin type III and SPRY domain-containing protein 2 (Minispryn) (SPRY domain-containing protein 1) (Q8BZ52)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:H0UZ81}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:H0UZ81}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:H0UZ81}. Note=In skeletal muscles and striated muscles flanks Z-disks. Partially colocalizes with RYR2 in the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:H0UZ81}.
Interaction partners:
Sequence:
MEEEAEEESGLGRSAAPKDFHFYHMDLYDSEDRLQLFPGDSSRIRREVTQAEDDRELGDEFVDEHRLGTLGYPSYGMRRRDPGREPRDWGEAAEAEDLGYGGGQGPLDQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEPADVFCITCKTPVRTVEKDFDTHKEHEVTPISKALEHAKDEVHKNMCKLEQQIIEMENFASHLEEVFITVEENFGRQEQNFECHYNGILETLAQKYEEKIQALGEKKREKLEALYGQLVSCGENLDACRELMETVEEMCHEEKVEFLKDAVAMTDRLGKFLKTKTDVELSAQPEFEDQTLDFSDVEQLMDAINTIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSSGKDRAEFTMMVKETYCSVTNLEPNTQYEFWVIAQNRTGPSPCSEHAVYMTAPSPPSIKTEAIRSCEEAVLICWESGNLNPVDSYTVELIQAETPEASGVTESVVGIPTCESLIQLQPRHSYTIYVRALNVGGTSARSEPATVHTTGSYFQLNKDTCHPWLTISEDGFTVVRSEKKSFRKELPPSKTQFTRCVAVMGNLIPVRGRHYWEVEVAEHLDYTVGVACEDVPKQEDLGANSLSWCMRHTFVSKRHRYEFLHNKMTPDIRITVAPRKIGVLLDYENAKLSFFNVDIAQHLYTFSCQLHQFVHPCFSLEKSGCLKICNGISMPKHVTFF
Protein: MIF4G domain-containing protein (Q21531)
Organism: Caenorhabditis elegans
Interaction partners:
- Eukaryotic translation initiation factor 4E-2
- Eukaryotic translation initiation factor 4E-3
- Eukaryotic initiation factor 4A
- RNA helicase
- Eukaryotic translation initiation factor 4E-5
- Eukaryotic translation initiation factor 4E-1
- Eukaryotic translation initiation factor 4E-4
- Eukaryotic translation initiation factor 2 subunit 2
- SUI1 domain-containing protein
- Eukaryotic translation initiation factor 3 subunit A
Sequence:
MSNAVSRGPGRGKPNQDHNAVPMQDSSQQFVMPFVNTSGPVNSNYQRMPMNQSAYPQYGQQQYNQPQTNHYYPPQAPQHQQQYGGYQRPDYGHQPQMYNQQYQGYQAPQQYHPEMPYQPAQPAQQQMTHTAPQEPKRQRKALEIVDPTTKKAIEVTPHLAPAAPAPAAPAAPIAPEEEKKKQNITLEFLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPNFSVPPPALGQTPPAASIAPQVVPSVPKTPEAPAKADYEVKQAETLVTPVSSPHASDTTTTTPASGTAESASTVADVRVTPTLTKEESKEETDDDKFEENDERESTPDVADSSTEKTPEELEIEKAQKEAEEIEKKKLREEALEKRIEELILAGSAVISDGTFGRDFMVTIREIEKVFSRTPCPLSPAQLADFGLDIKTMRVSDNKKPNFTPNWANKGGNRQQVPYRGRTTTDGTGRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (Q38B76)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTGLKIDIDMLPNDSDENLRMLHEGIRLGELTVSAEGLTTSMGQKYVLSPEDVLVNNTSFLGRGSSGSVRRATHRKTGKEIALKEIKFTGQTRMMEIRRELETLHRGGGPSPYLVDFYGAFCHEGSVFIAMECMDGSLDGVAGSVPPKVLECITRSILRGLSYLHKDRHLIHRDIKPSNILYSRDGSIKISDFGASSCLECTRGNAFSFVGTLTYMSPERLKGEPYSFPADIWSLGLAVAELALGKCPFIDRLSRANGSTEGCFWVLLQHLNGDGPVISLPSSMNASMTDFITTCIQREPSKRPTCDELRRHPFVAEGDEENDKNVIKQWLSTMQPKSSSHDIADVDGVCRMQQVPCSMGGADESSFDLDEELNKLVQ
Protein: TRAF3-interacting protein 1 (Q17595)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|ARBA:ARBA00004430}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
- Intraflagellar transport protein che-13
- Clusterin-associated protein 1 homolog
- Intraflagellar transport protein osm-1
- Intraflagellar transport protein 88 homolog
- Tetratricopeptide repeat protein 30 homolog
- CHE-2 protein
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 56 homolog
Sequence:
MSVEETREILEKVIQKPQLTDQLLSRPPFKFIVDIVSNVIKSTGYLKTDFTDDEIKSAGNDKNTKTAFLDKLIKILDDGSLKNVKAAKIISGKDAEETNKMLQMLGTNATSFNSRNGTGEEKKKKKVKKEDKKGDEEEKSTTKKRSSKKETHEEKEKSEKKKSAEEKEKKKKSSSSKERHKSSDRSSEKSSEKSSKEKKKEKSTTDEKPKKSKKDPSERHFKRQDSMIAVNGDAPDTPNNENGDEGYDDHEISEPTVISNMETDLSAQSLLIQQPVTSPLKTDDSGMGESPRMIKPEDRPPLIRPMTGAGGGRPMTSMGRPGTAASRPAPPKLKKKQIATVDSTPQVVVELKSEIISDAPKVETEDDSNFIMENDEEDGDRTARIEDLVDEEDRGALVQKIMETKAEIEDGGGQDQVEESDADKIMTVEREKMKQLQEKLQDLTRSAYPLARLFDFANDDIESMIKELERWRSEQRRNEQEDQNKKAAGFGDSSRLYNIIANLQKEINDTKEELSKARGRVLNNEKRIQLFISNV
Protein: Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) (Q03311)
Organism: Mus musculus (Mouse)
Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Appetite-regulating hormone
- Acetylcholinesterase collagenic tail peptide
- Albumin
- Amyloid-beta precursor protein
- Choline O-acetyltransferase
- Amine oxidase [flavin-containing] B
- Beta-secretase 1
- Vesicular acetylcholine transporter
- Neuronal acetylcholine receptor subunit alpha-7
- Amine oxidase [flavin-containing] A
Sequence:
MQTQHTKVTQTHFLLWILLLCMPFGKSHTEEDFIITTKTGRVRGLSMPVLGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIHNATQYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNPDAPGNMGLFDQQLALQWVQRNIAAFGGNPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFTGCSKENEMEMIKCLRSKDPQEILRNERFVLPSDSILSINFGPTVDGDFLTDMPHTLLQLGKVKKAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRKEFQEGLNMYFPGVSRLGKEAVLFYYVDWLGEQSPEVYRDALDDVIGDYNIICPALEFTKKFAELENNAFFYFFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLGRRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTMWPVFTSTEQKYLTLNTEKSKIYSKLRAPQCQFWRLFFPKVLEMTGDIDETEQEWKAGFHRWSNYMMDWQNQFNDYTSKKESCTAL
Protein: Flowering time control protein FY (Q6NLV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the regulation of flowering time in the autonomous flowering pathway by decreasing FLOWERING LOCUS C mRNA levels. Required for the negative autoregulation of FCA expression. Acts probably as an RNA 3' end-processing factor. Required for growth and development in plants.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cleavage and polyadenylation specificity factor subunit 3-I
- Cleavage and polyadenylation specificity factor subunit 2
- Protein arginine N-methyltransferase 1.5
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Cleavage stimulation factor subunit 77
- Cleavage stimulating factor 64
- 30-kDa cleavage and polyadenylation specificity factor 30
- Protein ANTHESIS POMOTING FACTOR 1
- Cleavage and polyadenylation specificity factor subunit 1
- FIP1[V]-like protein
Sequence:
MYAGGDMHRGSQMPQPPMMRQSSASSTNINPDYHHPSGPFDPNVDSFGAKRMRKHTQRRAVDYTSTVVRYIQARTWQRDSRDRTTLQPTPAAAVDMLPTVAYSDNPSTSFAAKFVHASLNKNRCSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKTAHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGRELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPCHEEYFVSGSSDGSICHWIVGHENPQIEIPNAHDNSVWDLAWHPIGYLLCSGSNDHTTKFWCRNRPADNPRDVLMQNQGYNEQGFGRQPDNFQPSEASPIPGAFVPGLTRNEGTIPGIGIAMPFDASSQGDHKQPLPGSMALGAPPLPPGPHPSLLGSGQQQGYQQQQQHQGHPQQMLPMPNMPHHQLPPSSHMPLHPHHLPRPMQMPPHGHMPPPSMPMSHQMPGSMGMQGGMNPQMSQSHFMGAPSGVFQGQPNSGGPQMYPQGRGGFNRPQMIPGYNNPFQQQQQPPLPPGPPPNNNQQHQ
Protein: Extracellular fatty acid-binding protein (A0A1D5NW85)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MRTLALSLALALLCLLHTEAAATVPDRSEVAGKWYIVALASNTDFFLREKGKMKMVMARISFLGEDELEVSYAAPSPKGCRKWETTFKKTSDDGEVYYSEEAEKTVEVLDTDYKSYAVIFATRVKDGRTLHMMRLYSRSREVSPTAMAIFRKLARERNYTDEMVAVLPSQEECSVDEV
Protein: Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein) (P37108)
Organism: Homo sapiens (Human)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular location: Cytoplasm.
Interaction partners:
- Signal recognition particle 19 kDa protein
- Signal recognition particle subunit SRP68
- Signal recognition particle subunit SRP72
- Signal recognition particle subunit SRP54
- Signal recognition particle 9 kDa protein
- Large ribosomal subunit protein uL23
- Signal recognition particle receptor subunit beta
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL14
- Signal recognition particle receptor subunit alpha
Sequence:
MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAPAAAATAPTTAATTAATAAQ