wanglab/gogpt-training-data huggingface dataset:
Protein: Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) (P48974)
Organism: Rattus norvegicus (Rat)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
- Guanine nucleotide-binding protein G
- Vasopressin V1a receptor
- Vasopressin V2 receptor
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Oxytocin-neurophysin 1
- Corticotropin-releasing factor receptor 1
- Pro-opiomelanocortin
Sequence:
MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLGRHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQGSGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREERRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGSKPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATMETSIF
Protein: Klumpfuss, isoform B (M9PF84)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Enhancer of split mgamma protein
- Protein deadpan
Sequence:
MTMAEGTDPMGHGHHTNPHNPPQQPPQHHPHHLPLPHPPPAPPPQLLNFNHHQQQYLPHMYPAAAAAAQSHSHYGGLQYPHPHALQHQHHPHQHQHHLPLALSLHQQAAAAAAVAAAVATNHSNNNNQASVANNNIVVPWKQRKRKRLSAVLDKLHHNNNNNNNNNNETHSNGMACKAEPMEMKGDLAEDAEQDEDHDGSVPDEEDDSVDQDGDAGKYIKSEQPVSEDEENEQEMDQDIEDISGEDLELSHSDDNDQDDSPRISMSPLQLQAAQSNLPQDQNQPMNKENPLHVDIKTEIPSPYDRYFPIPSPLFGYYLHTKYLNEVFRRRHDLYPSPLQHTPSSIASETETSPNAQERKSSSNHVLPHALLANNSPPPSLPSPPRSESSVTNNVATTTTSSTTKKRSSPKPKGKKGEKKPMPPPQERPLDLCMRNEVEPKKYKKSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPASSSHSGHMPITSAATPNHQPPPNSPYANAMNAAHAAAAAAAAAMIKMEMPLHPLHHQQMHHSQVPTTTVGVPVIKGDVASPTTKETVAWRYNLDVSPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRNPANDIAKAYSCDVCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRRDMITRHMRTHTRYDSRGGSREGREGREGREGKESRDSRRSNERIEEPNSPGSHSLLDMKMNMNMGMGMGLNMGLPMNPMSLLQEELLQKSQPGLTLGGPMPLVVKTESAXRCLYAAASRPFMTC
Protein: N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (SET and MYND domain-containing protein 2) (Q7M6Z3)
Organism: Rattus norvegicus (Rat)
Function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Cellular tumor antigen p53
- Cellular tumor antigen p53
- Histone-lysine N-methyltransferase SETD7
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Histone H3
- Histone H3.1
Sequence:
MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVFGENWNPSETVRLTARILAKQKMHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKHLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEIRKLSNPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEIAHGKDHPYISEIKQEIESH
Protein: Glutathione transferase 3 (P39996)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- Uncharacterized mitochondrial membrane protein FMP10
Sequence:
MPTKSTFSRWKKADLIDLANKLEIDGFPNYAKKSDMIDYLESHLNHLEKPVDFKDDYPELRSFYESMTVDQSKDERNEYGSGSGNGSGSGSCDTATNDSDLEKAYIKEDDDEKPQSGDETSATKPLSSRNANSNAKTNFNLLDFSTDNDSSTSAFTKFKFNFQEYLSDIRYQTQKLNENVQDYLSTISAVDTIFSLLEFSFLVRNILAAGQPTSSSSLASSLEAAVAAHNKYQYTLDFCLPILTWLLFFRGIPTLVSYYINFIRYDLNIELDPMTFNLTKFLISLAIFKTCNNKNIDFHSFRCVNQLWTQLCTVNRSLGMVPLVFSMVSCLLTLYVL
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (O73736)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Bone morphogenetic protein 6.
- Bone morphogenetic protein 7
- Mothers against decapentaplegic homolog 5
- Mothers against decapentaplegic homolog
- Bone morphogenetic protein 4.
- Mothers against decapentaplegic homolog 2
- Bone morphogenetic protein 5.
- Bone morphogenetic protein 2
- Mothers against decapentaplegic homolog 1
- Mothers against decapentaplegic homolog
Sequence:
MGHCSTQIIILFLLQFLQTSAKDVSIDCMCVGSDCNEQQCTGDQCYTSVIISNDVTTFKRGCLIGPASKRMTCSATASASHVVECCSQHMCNANVSKETLLRLLLTSPEEKKTVHYRVEMLVLFVLGPFVVLGLLSFLALLVCRRLHHGRLERLHEFDTEQGAIDGLIASNVGDSTLADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQLDVGNNPKVGTKRYMAPEVLDETIQTDCFDAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKIHSSLEKGKTDC
Protein: Protein RKD5 (AtRKD5) (RWP-RK domain-containing protein 5) (O81791)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00852}.
Interaction partners:
- Protein NLP2
- Protein NLP1
- Protein NLP3
Sequence:
MVDQGFFTLKKEKKKNILIKLFYVKILGFCFCDSWSSSDMAHSLTSLAVFQSVIRKEMVRSLHVYESVEIEREFWFKSKSCYVEKKAKPLFRSEDFRRPEISEGSVFGTWRCIFVFRFNHSLPRFPTLLCLSRNPKLEDIPNLANELKFISELKPSKIYEEEQCSSSTEGYYNSDLPKPRKLVLKQDLNCLPDSETESEESVNEKTEHSEFENDKTEQSESDAKTEILKKKKRTPSRHVAELSLEELSKYFDLTIVEASRNLKVGLTVLKKKCREFGIPRWPHRKIKSLDCLIHDLQREAEKQQEKNEAAAMAVAKKQEKLETEKRNIVKRPFMEIGIETKKFRQENFKKRHRASRAKKNQESLVTSSST
Protein: MADB protein (B5M9P7)
Organism: Phycomyces blakesleeanus
Interaction partners:
Sequence:
MESARQPQPLSFIMEPSGPTQALVPKPPTTVQAEFTRRKNWSQSILDELRDVVHVLSPKFKILYCSPASSEFLGYQPTELVNHLFTEYLHVDDADTFSREFRNASAENKPFKAYYRLLRKDGKYTSLETRGHFFKGCFFGLARCVPAQSTRMMDTFLDLKMENEILKRKLVNMKQKQQQQNLESEKSSPITSSSEDRSETADMDDDEFDGDFDEEEFLPNAAHVYTPGVNTSYDMLESVSLFTGLRYDLGERSRGISLGLVGELTTVAQLPPSMPSTINSIERVTVHDEDEETNEQQKRVKKKRIEVEAPKICTDCGTTSAPEWRKGPKGPKTLCNACGLRWAKTSKRPDGSDI
Protein: Probable malate dehydrogenase 2, mitochondrial (EC 1.1.1.37) (Q54D04)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the reversible oxidation of malate to oxaloacetate.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- malate synthase
- Fumarate hydratase, mitochondrial
- Citrate synthase, mitochondrial
- Citrate synthase
- Citrate synthase, peroxisomal
- phosphoenolpyruvate carboxylase
- NADP-dependent malic enzyme
- Aspartate aminotransferase, cytoplasmic
- ATP citrate synthase
- Aspartate aminotransferase, mitochondrial
Sequence:
MNKILTRSFSTGANFFASGKGKAPVRVAITGASGQIGYQLLFRIASGDMLGKDQPIILQCLELPGAMNSLKGVSMELDDCAFPLLKGIVQSDKPEEAFAGADYALLVGARPRSKGMERGDLLKANAEIFSVQGKALDKSANRDTLRVLVVGNPANTNALIAARNAPNIDPKRFSAMTRLDHNRGLAQLADKTGSAVTDIEKFCIWGNHSATQYPDINFGTVKGKSLVDTINDQKWVKDNFIPTVQQRGAAIIAARGLSSAASAASAAIDHMRDWTYGTNGQWTSMAIYSEGEYGADKGLYFSFPVIVDNKGKYEIVKGLKLDQFSQERFDATRKELLSEMDGVKELLP
Protein: Ribosome biogenesis regulatory protein (Q584V1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364132}.
Interaction partners:
- Ribosome production factor 2 homolog
- RNA-binding protein, putative
- rRNA processing protein, putative
- 60S ribosomal protein L5, putative
- Ribosomal protein L1p/L10e family
- Nucleolar GTP-binding protein 1
- Nucleolar GTP-binding protein 2
- Ribosome assembly factor mrt4
- Large ribosomal subunit protein uL5
- Nucleolar complex protein 2
Sequence:
MSEYHMDLGLLCVTNSSLISGPQRSEGDLHQSTLEAMKVLLKECCELPTATKRGKFDGSTTLLKLPQPVMQLPREKAPPKPKPPTAWEKFAMKKGIALNRKKTNRVFDEERQVWKDKWGKRAREEKEKYDWLREVGPNYVPQEEGGDPFLDERRVKKERLEKQKKKEEHNKRRSEHISRAQEEVKHLTAAAKHLATASNGKFDKVSLRKKGKK
Protein: Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (Q8BMJ2)
Organism: Mus musculus (Mouse)
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, cytoplasmic
- Arginine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase
- Glutamine--tRNA ligase
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
- Tyrosine--tRNA ligase, cytoplasmic
- Probable arginine--tRNA ligase, mitochondrial
- Aspartate--tRNA ligase, cytoplasmic
Sequence:
MAGRKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRLEKQKQSSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEESSAKPGDIVVRDKAKGKKSKAAAKAGSSKYQWDIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGTGVVTSVPSDSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESPLGIRPQQMTKDVWDYVFFKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLASCSSLRSGPADSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMMPAKGKKTDKQPAQRPSHCTIYVAKNYPVWQHITLTTLRSHFEANNGKLPDNKVIASELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMENIVYLTNSLELEHIEVKFASEAEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKIDIRQGDSCESIIRRLMKTDRGIKDLSKVKLMRFDDPLLGPRRVPVLGREHSEKTLISENAVFHVDLVSKKVHLTENGLRTDIGDTMVYLVH
Protein: Leucine-rich repeat-containing protein 23 (Zgc:101782) (Q5XJM1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDSGEDEVLKADSDHEGENEDLEEKDKSDGDQLESCPLTQDILARSLSLLCRTGNGLSHAYVRLDLKNKGLTDLALLSSFIHLRYLDLSSNHLSDFSPLAGLTQLLWVKGDSNLLQGFEGQPFGQLTFLQWLSIASNRLFDVTGLGGPALETLNLTGNGIQTMQGLDHPNLTNLVTLELRGNCLETTDGIYLPNLRHLYLAQNNIKKLEGLEKLERLITLHLRHNQLETLDGLSASMKCLEYLNVRGNLISSMRALQTLASVGQTLKALVLLDNPIAKTDDYRLYVISQLPHLERVDKDPVTPEEKFEAQKKEFEDDNAEDQEDD
Protein: cellulase (EC 3.2.1.4) (Endo-beta-1,4-mannanase F) (Q4WM09)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Glucanase
- Probable endo-beta-1,4-glucanase celB
- Extracellular endoglucanase, putative
- Endoglucanase, putative
- Probable 1,4-beta-D-glucan cellobiohydrolase C
- cellulase
- cellulase
- beta-glucosidase
- Probable 1,4-beta-D-glucan cellobiohydrolase B
- Probable beta-glucosidase A
Sequence:
MKASTIICALLPLAVAAPNAKRASGFVWFGSNESGAEFGETKLPGVLGTDYIWPDASTIKTLHDAGMNIFRVAFRMERLIPNQMTGTPDATYLNDLKATVNAITSLGAYAVIDPHNYGRYYGNIISSTDDFAAFWKTLAAQFASNDHVIFDTNNEYHDMDQTLVLNLNQAAINAIRAAGATSQYIFVEGNSWSGAWTWTTVNDNLKALTDPQDKIVYEMHQYLDSDGSGTSATCVSSTIGQERVQAATQWLKTNGKKGIIGEFAGGANSVCQSAVTGMLDYLSANSDVWMGAAWWAAGPWWADYIFNMEPPSGTAYQNYLSLLKPYFVGGSGGNPPTTTTTTTQPTTTTTTTTAGNPGGTGLAQHWGQCGGIGWTGPTACASPYTCQKLNDYYSQCL
Protein: Uncharacterized protein (Q57ZR3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPKKKPPCPSVTPQLYEKSHKPSVTVGMGMKGSAASTACWRDQVDKEEQLHAIWAKRYDRRSNARLVESLKRTLQREKDSAEQYRKDNDALSTILFSKDVSDAGRLTTVYLKARNRLAPQEKYLRAQTAAQEVGWGIPEAMRGGDSVEFTGTPALPRLTKASAMAYRRPDDEDHAELFGYTLMCSFCGGKP
Protein: Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) [Cleaved into: Secretory component] (P01832)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Subcellular location: [Polymeric immunoglobulin receptor]: Cell membrane {ECO:0000250|UniProtKB:P01833}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secretory component]: Secreted {ECO:0000250|UniProtKB:P01833}.
Interaction partners:
- Immunoglobulin J chain
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Interleukin-2
- GPI mannosyltransferase 1
Sequence:
MALFLLTCLLAVFSAATAQSSLLGPSSIFGPGEVNVLEGDSVSITCYYPTTSVTRHSRKFWCREEESGRCVTLASTGYTSQEYSGRGKLTDFPDKGEFVVTVDQLTQNDSGSYKCGVGVNGRGLDFGVNVLVSQKPEPDDVVYKQYESYTVTITCPFTYATRQLKKSFYKVEDGELVLIIDSSSKEAKDPRYKGRITLQIQSTTAKEFTVTIKHLQLNDAGQYVCQSGSDPTAEEQNVDLRLLTPGLLYGNLGGSVTFECALDSEDANAVASLRQVRGGNVVIDSQGTIDPAFEGRILFTKAENGHFSVVIAGLRKEDTGNYLCGVQSNGQSGDGPTQLRQLFVNEEIDVSRSPPVLKGFPGGSVTIRCPYNPKRSDSHLQLYLWEGSQTRHLLVDSGEGLVQKDYTGRLALFEEPGNGTFSVVLNQLTAEDEGFYWCVSDDDESLTTSVKLQIVDGEPSPTIDKFTAVQGEPVEITCHFPCKYFSSEKYWCKWNDHGCEDLPTKLSSSGDLVKCNNNLVLTLTLDSVSEDDEGWYWCGAKDGHEFEEVAAVRVELTEPAKVAVEPAKVPVDPAKAAPAPAEEKAKARCPVPRRRQWYPLSRKLRTSCPEPRLLAEEVAVQSAEDPASGSRASVDASSASGQSGSAKVLISTLVPLGLVLAAGAMAVAIARARHRRNVDRVSIGSYRTDISMSDLENSREFGAIDNPSACPDARETALGGKDELATATESTVEIEEPKKAKRSSKEEADLAYSAFLLQSNTIAAEHQDGPKEA
Protein: Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) (Secretory protein 11) (Signal peptidase I) (P15367)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10206957, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:2644273}; Single-pass type II membrane protein {ECO:0000269|PubMed:10206957, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:2644273}.
Interaction partners:
- Signal peptidase complex subunit 1
- Signal peptidase complex subunit 3
- Signal peptidase complex subunit 2
- DNA-directed RNA polymerase II subunit RPB7
- Protein transport protein SEC1
- Ras-related protein SEC4
- Protein transport protein SEC9
- Exocyst complex component SEC6
- Rab guanine nucleotide exchange factor SEC2
- Protein transport protein BOS1
Sequence:
MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE
Protein: DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta) (P9WGY9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Interaction partners:
- ECF RNA polymerase sigma factor SigL
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit alpha
- RNA polymerase-binding transcription factor CarD
- RNA polymerase sigma factor SigA
- DNA-directed RNA polymerase subunit omega
- ECF RNA polymerase sigma factor SigH
- RNA polymerase sigma factor SigB
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL3
Sequence:
MLEGCILADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA
Protein: Hydroxyproline-rich systemin (Defense-signaling glycopeptide hormone) [Cleaved into: HypSys I (TomHypSys I); HypSys II (TomHypSys II); HypSys III (TomHypSys III)] (Q7XAD0)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Activates a lipid-based signal transduction pathway in which linolenic acid is converted to jasmonic acid, a potent activator of defense gene transcription. Induces synthesis of proteinase inhibitors I and II in leaves when supplied through cut stems.
Subcellular location: Secreted.
Interaction partners:
- HP domain-containing protein
Sequence:
MISFFRAFFLIIIISFLIFVGAQARTLLGNYHDDEMLIELKLESGNYGRTPYKTPPPPTSSSPTHQEIVNGRHDSVLPPPSPKTDPIIGQLTTITTTPHHDDTVAAPPVGGRHDYVASPPPPKPQDEQRQIIITSSSSTLPLQASY
Protein: Protein translation factor SUI1 homolog 2 (Q94JV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in translation.
Interaction partners:
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit G
Sequence:
MSDLEVQVPTAFDPFADANAEDSGAGTKEYVHIRVQQRNGRKSLTTVQGLKKEYSYSKILKDLKKEFCCNGTVVQDSELGQVIQLQGDQRKNVSTFLVQAGLVKKDNIKIHGF
Protein: Neuronal pentraxin-2a precursor (Nptx2 protein) (A8E4K4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRALFVALLLVYASGSGKVAGANGAKGNRFVCTAVPAGTDLSCPVETTNRVQSTSPQEEELRNTIIQLRETILQQKETIVSQQGTIKELNSKLARCEADVRSRGSARRKDYSKNTMGDLPRDPTESVEQLGKTMQSLKDRLESLELRTNTSNGAFPSELRDLLKRRLSDLEGQLLTRVAELEEEKSQLYNETAAHRQRTENTLNSLLERITELEKSNSAFKSPEDFKVALPLRTNYLYGRIKKSLPEMYAFTVCMWLKSSASPGIGTPFSYGVPGQANEIVLIEWGNSPMELLVNDKVAQLPLSVSDGRWHHICITWTTRDGFWEAYQDGERLGTGENLAPWHPIKPGGVIILGQEQDIAGGRFDATQAFVGELSHFNMWDRVLRPIDISAMANCSAYMPGNVVPWVDANVEVFGGATKAALEICEERLFDS
Protein: FI01467p (Varicose, isoform D) (Q9VIJ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRWSARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY
Protein: Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein) (Q91WK7)
Organism: Mus musculus (Mouse)
Function: Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19064729}. Cytoplasm {ECO:0000269|PubMed:19064729}. Midbody {ECO:0000269|PubMed:19064729}. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation.
Interaction partners:
- Lipoyl synthase, mitochondrial
Sequence:
MAATGGGADDESRSGRSSSDGECAVAPEPLAEAGGLVSFADFGVSLGSGAGLPGRSVGRAQSSLRYLQVLWQQDVEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQQDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHSQCLEAVRLEVKQIIHMLREYLERLGRHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR
Protein: Glutathione S-transferase (EC 2.5.1.18) (F6XZQ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEEKCNVGWSSRRNLDTVCRTSQRILCQNRENE
Protein: MICOS complex subunit MIC10 (Q38C83)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
- Transmembrane protein
- Mitochondrial fission process protein 1
- Thioredoxin domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
Sequence:
MTAPVSTLASQKVLLDRDTLTEAEKWRYVVDNTLKKGSLGFLTGAALSLVVFRSVPVRVAATAFGCGFGIGKSYIDTRYILGHDVSVETVWTAEVLRKGFRGSTGVSDRESSGS
Protein: HL01062p (Nebulosa, isoform B) (Q9VU17)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- HDC03535
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MSTASSSNSSGEEANKKSGSNNEESSHLLESAENGAKYGSRQPVKIVKASDNGRTSSTPHDQENLLGNMVHTSTSNNSQKWPQYVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGILPLIFGAIFFFMPESPTYLVSKDRSENAIKSIQWLRGKEYDYEPELAELRETDRETKANKVNVWAALNRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQELAGNRSTPQAIPAEK
Protein: Apamin (APM) (Apamine) (P01500)
Organism: Apis mellifera (Honeybee)
Function: Neurotoxin that blocks the small-conductance calcium-activated potassium (SK) channels KCa2.1/KCNN1/SK1, KCa2.2/KCNN2/SK2 and KCa2.3/KCNN3/SK3. Also irreversibly blocks the voltage-gated potassium channel Kv1.3/KCNA3 (IC(50)=13 nM). Potently blocks human, rat and mouse KCa2.2/KCNN2/SK2 channels (IC(50)=27-140 pM), and moderately blocks human and rat KCa2.3/KCNN3/SK3 channels (IC(50)=0.6-4 nM), and human (IC(50)=0.7-12 nM) and mouse (IC(50)=28 nM) KCa2.1/KCNN1/SK1 channels. However, other reports found that it did not block the human KCa2.1/KCNN1/SK1 channels. Also able to inhibit neuromuscular transmission by a mechanism independent of the blockade of SK channels, which may involve the activation of inhibitory muscarinic M2 receptors on motor nerve terminals.
Subcellular location: Secreted {ECO:0000269|PubMed:5601655, ECO:0000269|Ref.4}.
Interaction partners:
- Melittin
- Phospholipase A2
- Hyaluronidase
- Hyaluronidase.
- Calmodulin-like protein 4
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MISMLRCIYLFLSVILITSYFVTPVMPCNCKAPETALCARRCQQHG