wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclin-dependent kinase 7 (EC 2.7.11.23) (Cell division protein kinase 7) (Q24216)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cyclin-H
- CDK-activating kinase assembly factor MAT1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 1
- Cyclin-T
- General transcription factor IIH subunit 3
- Transcription initiation factor IIB
Sequence:
MLPNANDKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAKEGANPQTGDTKPALKRKLVETTVRGNGLAQKKRLQF
Protein: Protein phosphatase 2C, putative (EC 3.1.3.16) (Q586U3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDLFGAYASHAQAVLCTPVRDKYSILMEDDKIRVGTSSMQGWRSTMEDAHAIHLSLPNLPLHISPHDAAMAAVFDGHSGCKTAQFAATHMARWITSSESFVSGNVENAIFEAFISGDAAIRRSMPHEQSGCTGNCIVLVQNNLYCGNVGDSRAVMCRGGVPLPLSEDHKPTLLREKERIKKAGCYVRNGRVNGILSLSRALGDFAFKDHHLKPEDQAISAVPDVLHVKLTPQDEFVVIACDGVWEKFSNERVVKFIREEVGDHGDLSLACERLMDSCLAPVSAAPGADNMTVIIVQFKSSFLKRVEDGFADDHSSNVKL
Protein: Insulin [Cleaved into: Insulin B chain; Insulin A chain] (P67970)
Organism: Gallus gallus (Chicken)
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular location: Secreted.
Interaction partners:
- Tyrosine-protein kinase receptor
- Tyrosine-protein kinase receptor.
- Appetite-regulating hormone
- Insulin receptor substrate 1.
- Insulin degrading enzyme
- Albumin
- Insulin receptor substrate 4.
- Pro-glucagon
- Tyrosine-protein kinase receptor
- Uncharacterized protein.
Sequence:
MALWIRSLPLLALLVFSGPGTSYAAANQHLCGSHLVEALYLVCGERGFFYSPKARRDVEQPLVSSPLRGEAGVLPFQQEEYEKVKRGIVEQCCHNTCSLYQLENYCN
Protein: Interleukin-1 receptor-associated kinase 1 (A0A8I6AR42)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPASVLPPSTGAPRPSSISAGSETEDWSPRKLQSSASTFLSPAFPGSQTHSESELLQVPLSDSLGPPLQSSAPSSIKPSPESPVSGLQRARPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTVVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGFYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGANPSQSSTVARTCTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEVGVTLKSTQPTLWMGVATDAWTAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKRPPMTQVYKRLEGLQAVPPWKLEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTRAPAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPDSHPSPVSFREASCTQGGTTRESSLRSGPGFQPTTMEGSSMGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQLLSSGFFPDFMDIDAIGNMSELLINHI
Protein: Small leucine-rich protein 1 (H3BR10)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein CXorf58
Sequence:
MLSKGRSPRRKQVQTQRKAALVLSVTPMVPVGSVWLAMSSVLSAFMRELPGWFLFFGVFLPVTLLLLLLIAYFRIKLIEVNEELSQNCDRQHNPKDGSSLYQRMKWT
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) (A0A0R4IVA6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAGAKPGVHALQLKPVSVNEVLKRGSKFIKWDEEANSTPSLITLRVDPNGFFLYWTGGTSMEAEILDMSHIRDTRTGKFAKTPKDQRIREMLFSGKADGNSDSRLLTVVYGNDLVNISFLNFQAVQDGYCKLWTDELFKLATNMLSQNASRNTFLLKAYTKLKLQVTQDGKIPVKNILKMFSDKKRVEMALEHCGLIFNRVDGIKPDDFTWEMFQNFLNKLSPRPEVERIFVDLGSKGKPFLSLDQLMDFINRKQRDSRLNEVLYPPLKRDQVRQLMEKYETNTSQLERDQISLMSFTKYLGGEENTVVPPERLDIIDDMNQPLSHYFINSSHNTYLTVGQLTGLSSVEMYRQVLLTGCRCIELDCWKGRPPEEEPIITHGFTMTTEIPFKDVIEAIAESAFKTSPYPLILSFENHVDSAKQQAKMAEYCRSMFGDALLIDPLDKYPLVPGQQLPSPQELLGKILIKNKKKHHHRASNGGSIRRKDGTDEQSSPLNDCPLSDGDVGQLMSNGGEKLAERMAKDHDNSKSIDRGDGESDEEEEEEPIPDPKKHNNTDEGTAYSEVNATEEMSTLVNYIEPVKFKSFEVAAKRKKFFEMSSFVETKGMDTLKNSPTEFVEYNKKQMSRIYPKGTRVDSSNYMPQLFWNVGCQMVALNFQTLDLAMQLNMGVFEYNGRCGYLLKPEFMRRTDKHFDPFTTDIVDGIVANTVKVKIISGQFLNDKKVGVYVEVDMFGLPADTKRKYRTKTSNNNSLDPVWDDETFVFNKVVLPTLASLRVAVYEENGKFIGHRILPVSALRPGYHYICLKNELNQPLMLPSLLVYTEVQDYIPNEHQEYAEALTNPIKHLSLLAQRESQLLALMEDPTEGGPTKQEEGDGTDSSCVTSADPIFPLPSSPTLPSVPTDLNPPPSGQKEDLVNNVLKVIEPESVDELKQHNSYLKLLKKQCKEFKELSKKHLKKMLALSKEQKTLFNQQSSELQRKRSQIEKRIRTSLKKNGSEDSVHRELNELDLELQKQMEQFREEHMQKLLVLRQGQLQMEKEVKQFHLKEANQKLKDIAIECQAAQIKKLKDVCDKEKKELQKMLDRKRLNSIVEARKAEKEIRDVNEINRKHIQESVSLIRQLEVSQGKRQEKLKALHKDILQKIEEEIPMNQARLTRDFEAELKRLPEEISQYLQELESKGSRKDSLMGQTNDGPNSGPPSNCSTPPYSSPNHSWSNIANVSSLLLDSSTSSSSAKSETDTTGVY
Protein: Testis tissue sperm-binding protein Li 37a (A0A140VKC0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
Protein: Double homeobox B-like 1 (Double homeodomain-related protein) (Q3UY88)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MELSCSTGLLEKEARRRRIILTQSQKDTLRVWFEKNPNPDLATRGHLAKELGISESQIMTWFQKHRKIRKQAEFACCSEESQEQEQDKPRVKEARRSRTHFTKFQTDILIEAFEKNRFPGIVTREKLAQQTGIPESRIHVRCASLCLWQPTCPYHKPLFSRAVDGQSQATHGCPCALDTGCKYLVFPATVWRNSHIRPAES
Protein: Dorsocross1, isoform B (M9PBY6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MLPFNMPHQQPHMMLPSRPTLPGVEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIRSSELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKRKLNSSGNSTLESEDDGSSVSSCDSPQAKRQRQDFEQDSTGSVSPAYYGATHPVANPMSPYLRHHLSYGPSGAAGLPPSIAAAYFGGVPPQILPMPPATYAPTVAPVSPVASQPVGSSTPTTSPRPSTSTKRNSFSISAILAY
Protein: Mid1, isoform A (Mid1, isoform B) (RE02133p) (Q9I7V0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncoordinated 79, isoform C
- Sodium leak channel NALCN
- Protein unc-80 homolog
Sequence:
MRPGPGLVVMALAFISGARRGSSSSISSATATPTAAATSAAAAAAAAATSAASTSAAAAAAANTAGGRKRGRSGGGVGGGGVATTLPSTGESSSSSFVRSSGSYLLPIFLPHYLDFALQFHPQLPPREYSQGRAHSESWASSRIADRLQQRRRRRESSSSRDIAGRAGGTGGSGADSGGLAATTGHSTESSEANNQEDGEDRGLTVQFPSSQAYDEDQDIFALVAEDDLLSEESFDRLIKLNEDADEEDYNLQQQHLPQHKQQQQQPGAETEIDTEPESETETETETETDTEAEVEVERETEQQQQDESRLIDEGVLQHSDHSNSHSKEFAISYDNNNNKREASGHILDAQTAQLIGHKDNTVPAVASTESAGGGSITTSLPAPVDLKKSILGTATSLTRLNPWISACDLAQPGTGTDLQGQCSAGTLPMAWVDEGPGPPTCPRSCAEQQQQKPVASKAKRSATSNNKVKYFVNYKTTQMRLRRAGDHAMDATDSHSPLASERPPSTTDDQDVDVSSTTEEAEPEPTLSYSHLHAQEPVLAHQQDPREREQEQQEQQQCLEYLGDSAESSPQHLCGLQSPGHLLERLKVLRLRNCCERSVFSSLHTLALNASLTDRQECVRVLSDLLDVDGLANRITCELAEILFRFDCRQVYSLINQCDDCKEAYRRWVCSTLVPYFAEPKDVSPQPKDEGQGKGKRSARSAASAEATAMADGIKHKSLKLISNNNKSNNGNNMNERQINQKHDKSSNANANANSNASKDIDRSAEEAIDRDLVQTFYDVVGLSKPRHGEEEVLPENEAGLGRSADSEVDKGAEPDRKRSRNREAELELDTEAEAEQQSNNFISTANNSDPRATDPVISKLQKRSTRKTEFRKRRRIRPCLSVCQTVEQKCPYLLPADRAPALPTQYAGEPTFLCLDQNIPETGAQLEKSSYGPNDCCYSYCNGPASGICTVCQDFGQPGTEEREMAGNSTRRVHNITLSLSSHPGEHARAKSVALALRNVSQTGSDPDAVETLLDRLPYYASHDGIFYYDEEGEMPHASLSGDCAVVPAATTRCTIPYYASGTGAVAKPPTQLLVWLSALLGLLSSCGAARQRWSCQWSSGCGGHRARSRQAVACEANCHEQELVKSRSCSQRSPKVRREKPGQDQDAELVAFRTWLWSSSWHAYKLTCSKIRYFSSRSRFKGETRAARSANSKDPSGLQWSRAAGCTRTRNYRFFYYYNYNINDWWRRWWRCLSSGAL
Protein: Serine/threonine-protein kinase VPS15 (EC 2.7.11.1) (Vacuolar protein sorting-associated protein 15) (AtVPS15) (Q9M0E5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21833541}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P22219}; Lipid-anchor {ECO:0000250|UniProtKB:P22219}. Endosome membrane {ECO:0000269|PubMed:22361507}; Lipid-anchor {ECO:0000250|UniProtKB:P22219}.
Interaction partners:
- Beclin-1-like protein
- Phosphatidylinositol 3-kinase VPS34
- Autophagy-related protein 3
- Autophagy-related protein 16
- Autophagy-related protein 101
- Autophagy-related protein 9
- Serine/threonine-protein kinase ATG1c
- Serine/threonine-protein kinase ATG1b
- Autophagy-related protein 11
- Autophagy-related protein 18b
Sequence:
MGNKIARTTQVSATEYYLHDLPSSYNLVLKEVLGRGRFLKSIQCKHDEGLVVVKVYFKRGDSIDLREYERRLVKIKDVFLSLEHPHVWPFQFWQETDKAAYLVRQYFYSNLHDRLSTRPFLSLVEKKWLAFQLLLAVKQCHEKDICHGDIKCENVLLTSWNWLYLADFASFKPTYIPYDDPSDFSFFFDTRGQRLCYLAPERFYEHGGETQVAQDAPLKPSMDIFAVGCVIAELFLEGQPLFELAQLLAYRRGQHDPSQHLEKIPDPGIRKMILHMIQLEPEARLSAEDYLQNYVGVVFPNYFSPFLHTLYCCWNPLPSDMRVATCQGIFQEILKKMMENKSGDEIGVDSPVTSNPMNASTVQETFANHKLNSSKDLIRNTVNSKDEIFYSISDALKKNRHPFLKKITMDDLGTLMSLYDSRSDTYGTPFLPVEGNMRCEGMVLIASMLCSCIRNIKLPHLRREAILLLRSCSLYIDDDDRLQRVLPYVVALLSDPTAIVRCAAMETLCDILPLVRDFPPSDAKIFPEYIFPMLSMLPEDTEESVRICYASNIAKLALTAYGFLIHSFQLSDVGVLNELNSQQISTTPASETPSHLQKANGNAQLQQLRKTIAEVVQELVMGPKQTPNVRRALLQDIGELCFFFGQRQSNDFLLPILPAFLNDRDEQLRSVFFEKIVYVCFFVGQRSVEEYLLPYIDQALSDQTEAVIVNALECLSTLCKSSFLRKRALLQMIECVYPLLCYPSQWVRRAVVTFIAASSECLGAVDSYAFIAPVIRSYLSRLPASIASEEGLLSCLKPPVTREVVYRIFEKTRNPEFMAKQRKMWYSSSPQSKDWESVDLFDKDAGELNSVECRAEQKQSVEGKKQIKSASKQPEVQGKYAEKDAKLRIPRNPRPNASNTVELRDPVYPEKLQFSGFMAPYVSGANSFIEPENIPLYSFSMDKRAATNPPVASESSLQMNSLGMGSLSVPWMDSMSKSFNLASSVPVPKLISGSFHVGTNPKQFYRVVHEPESRENDQISSAISKFQDLGVSSSSKSASVTSEDASSPADLVGEPSLSRTSVPDSGWKPRGVLVAHLQEHRSAVNDIATSSDHSFFVSASDDSTVKVWDSRKLEKDISFRSRLTYHLEGSRGMCTTMLRNSTQVVVGASDGVIHMFSIDHISRGLGNVVEKYSGIVDIKKKDVKEGALVSLLNYTADSLSGPMVMYSTQNCGIHLWDTRSDLDAWTLKANPEEGYVSSLVTSPCGNWFVSGSSRGVLTLWDLRFRVPVNSWQYPIICPIEKMCLCFLPPSVSVSTTMKPLIYVAAGCNEVSLWNAEGGSCHQVLRVANYENETDVSEFQWKLPSNKVNPKPNHRQNMSSKYRIEELNEPPPRLPGIRSLLPLPGGDLLTGGTDLKIRRWDYSSPERSYCICGPSLKGVGNDDFYELKTNTGVQFVQETKRRPLATKLTAKAVLAAAATDTAGCHRDSVQSLASVKLNQRLLISSSRDGAIKVWK
Protein: MADS-box transcription factor 55 (OsMADS55) (Q69TG5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that acts as negative regulator of brassinosteroid signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MARERREIRRIESAAARQVTFSKRRRGLFKKAEELAVLCDADVALVVFSSTGKLSQFASSNMNEIIDKYTTHSKNLGKTDKQPSIDLNFFLIILLRTYTNSYAYIHLLLQLEHSKCSSLNEQLAEASLQLRQMRGEELEGLSVEELQQMEKNLEAGLQRVLCTKDQQFMQEISELQRKGIQLAEENMRLRDQMPQVPTAGLAVPDTENVLTEDGQSSESVMTALNSGSSQDNDDGSDISLKLGLP
Protein: GH12682p (Q95U27)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGHNGGGSSNGGANYVEESWMYNFCLKCRGEEPSASWEPPFWQKIFPYPLCPTFRTVSRLISIILIGVLIWVTAFVIIGDSAAPGGQLFGLVVLTVAANFGGYLISLTTLPRLIGMLLVGILFQNVGWADIDGDFSKVTAHLRKFALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMAVMSHFLLDLPWIWAFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAGVDDALSVAIFGIISTVMFSDKGLAYQIAQAPVCILGGLGFGVVWGSLARIFPEKGDAYVVPLRTLLLFTGGLMAIYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDNPVSTAFEIFWMIFEPILFGLTGATIKIRELDSHTVSIGAACIFTGAILRILTTAGIAFGDRLNTKEKFFVGLSWMAKATVQAALGPVALKHLGDDATEEERNWANIVQTICVFSIVLTAPLGAIMISVTGTKLLTKTKQPQDLSGWRRSHRPSIRDISIIDEEEEREDPEIPEDKETHDNTLNNAHIPSISYTYNT
Protein: Vacuolar protein-sorting protein BRO1 (BRO domain-containing protein 1) (Q5AJC1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.
Subcellular location: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
Interaction partners:
- Vacuolar-sorting protein SNF7
- Ubiquitin-binding ESCRT-I subunit protein
- Vacuolar protein-sorting-associated protein 36
- ESCRT-III subunit protein
- Vacuolar protein sorting-associated protein 27
- ESCRT-III subunit protein
- Vacuolar protein sorting-associated protein 4
- ESCRT-III subunit protein
- Vacuolar-sorting protein SNF8
- pH-response transcription factor pacC/RIM101
Sequence:
MKTHLLVVPSKKTEEVNWVKPLNNYLLSIYGNTLQYQDDINSLNKLRQDIRGVNADDTGLKLYYSYYSKLELIDLRIPFHDLNKSKKLQFEWFDSFSSLPYTQNSLAFEKANVLYNIGAILSRFAQFKYNESQQLNGPEGETAFKQSISMLQQSSGIHQFINKNFLHAPSQDLAQSTIKFLSKLMMAQSQEIFTLKVISGDLNQSKNSLIAKLCKSTSVLYEDCYNMINKNKKEGFKITNESYDGNDYEDDLDDDDCDDLEGFLERPEDTEDSDNRYVAAELDSSWISIIYFKYEYYKSLAYYFNGLHLDANRKYGDAIAYLTKSQEVLNGVHSSTLKQVSKGSGDVYELLDNYKYQKDAVTIRLNDLNKDNDLIYHDIVPNLVTLPEIKPMDSTKIIKLGDNAMFHEINEKNYNNFLVNVVPVNIHELSSYYSEEKSQYLRNEIDHFEVSNEEVSSVLEYLKLPKALVSIKESLRGTSSKGNTRNIDELLSQSVIDKVNEISSQYSNDIQRKNTIENSRKEIYQLIKFLTENNCQDDAIQLKKILYDASVSDTKLFALVDETYHQTLGKGIQSTEFKSLFKTVDNKSSNQDSEISLLDIIDDDDDDNTNQDKQIKNIEDYLNDLNNIKQAKFKLIEKLKKEIHNDDISDILVLNMKLKSTNEIKSIIFPEELKKFNPFTNELDKLITNEKSIIEQLKSRWNQLISNPQIKNLQTETNSKNRLIISQSEKIDQFYGNWLKYHNGLIAGEKFYNQLLDQFKNFRNNIDNQLNQGMRSLNIGQQFPTQPMLNRTQSSGLQSNYTGQSSISHSGSLSGQPSGGYNQPQPQQQQLQQQQQQQQQAQFSGAYNQQYSQPHGGYTQFQGYGQGQGQSQTGYQRQPPPPPPQLPPKQSMGSYNFATTLQQQQLPPQQQQQPQQQRTPQNESNLIYDNPSTYNPNMYNFFSSK
Protein: IKAROS family zinc finger 1 (Q5SWU0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTTSGAQQNSKSDRGMGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGMYPVIKEETNHNEMAEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDMPYDSANYEKEDMMTSHVMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSGLIYLTNHINPHARNGLALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS
Protein: Superoxide dismutase [Mn] (EC 1.15.1.1) (P0A4J6)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a critical role against oxidative stress, affecting both the survival and the virulence of S.pneumoniae.
Interaction partners:
Sequence:
MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK
Protein: Clusterin associated protein 1 (I3L3S9)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MSFRDLRNFTEMMRALGYPRHISMENFRTPNFGLVSEVLLWLVKRYEPQTDIPPDVDTEQDRVFFIKAIAQFMATKAHIKLNTKKLYQADGYAVKELLKITSVLYNAMKTKGMEGSEIVEEDVNKFKFDLGSKIADLKAARQLASEITSKGASLYDLLGMEVELREMRTEAIARPLEINETEKVMRIAIKEILTQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLETLQSVRPCFMDEYEKTEEELQKQYDTYLEKFQNLTYLEQQLEDHHRMEQERFEEAKNTLCLIQNKLKEEEKRLLKSGSNDDSDIDIQEDDESDSELEERRLPKPQTAMEMLMQGRPGKRIVGTMQGGDSDDNVSPPLPSVVLCTLGLAVPIDGSG
Protein: Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) (Q2M2Z5)
Organism: Homo sapiens (Human)
Function: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16980960}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24680887}. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively. {ECO:0000269|PubMed:24680887}.
Interaction partners:
- Sodium channel and clathrin linker 1
Sequence:
MSRTLASAVPLSSPDYYERLGQLQHGLRDSEKKRLDLEKKLYEYNQSDTCRVKLKYVKLKNYLKEICESEKKAHTRNQEYLKRFERVQAHVVHFTTNTEKLQKLKLEYETQIKKMLCSKDSLGLKEELTDEDREKVAVHEGINSGTAMSRGLYQPATIFMGRQMSAILSMRDFSTEHKSPQPTKNFSIPDPHSHRQTAQSSNVTDSCVVQTSNDTQCLNKSDNIDGKASLQIGEKMPVTASVLSEEEQTHCLEIGSNTRHGKSNLSEGKKSAELNSPLRERLSPENRTTDLKCDSSSGSEGEILTREHIEVEEKRASPPVSPIPVSEYCESENKWSQEKHSPWEGVSDHLAHREPKSQKPFRKMQEEEEESWSTSSDLTISISEDDLILESPEPQPNPGGKMEGEDGIEALKLIHAEQERVALSTEKNCILQTLSSPDSEKESSTNAPTREPGQTPDSDVPRAQVGQHVATLKEHDNSVKEEATALLRKALTEECGRRSAIHSSESSCSLPSILNDNSGIKEAKPAVWLNSVPTREQEVSSGCGDKSKKENVAADIPITETEAYQLLKKATLQDNTNQTENRFQKTDASVSHLSGLNIGSGAFETKTANKIASEASFSSSEGSPLSRHENKKKPVINLKSNALWDESDDSNSEIEAALRPRNHNTDDSDDFYD
Protein: Muscleblind like splicing regulator 1 (C9JP00)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMTQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPDTHNICRTSD
Protein: Erv29p (Q5AMR7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Golgi SNAP receptor complex member 1
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Emp24p
- Erp5p
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- ER lumen protein-retaining receptor
- Endoplasmic reticulum chaperone BIP
- Endoplasmic reticulum vesicle protein 25
- Protein transport protein SEC61 subunit alpha
- Dolichyl-phosphate-mannose--protein mannosyltransferase 4
Sequence:
MSYRGPNQFGNQPPHHGIPSQPQPHIGPISSSKSPLEQFEDVAKKVEDWIDDYFKVLKPYVPAIGRAFLVATFYEDTLRIFTQWNEQVYYLHNYRHYWRWLTVLFLINNMVVMTVASTLVIARKKNNIATIALIVVVIIQGIGYGLLFDAQFVLRNLSVVGGLVLAFSDSIVRDKRSLNMPGLPMLNNQDNKKYFLLAGRILLVLLFLGFVFSSDWSLGRVFIIIIGLTSCASIVVGYKTKFSAAIMLIVLFLYNVFTNQFWAYASQDARRDFLRYEFFQVLSIVGGLLLVVNAGAGEFSIDEKKKIY
Protein: Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 12 kDa protein) (Q871K1)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:226365}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00128}; Matrix side {ECO:0000250|UniProtKB:P00128}.
Interaction partners:
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 5, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b
- Cytochrome b-c1 complex subunit 10, mitochondrial
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
Sequence:
MSAPSLVQAVAKRGWLNKMLKPVSNWYINAAGYRQMGLRADDLISEENETVLAALQRLSPKESYDRIYRIRRATQLSLTHKLLPKNEWTTQEEDVPYLRPLIDQIEAEAAEKDALDTLAVVKN
Protein: Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) (P25490)
Organism: Homo sapiens (Human)
Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:23385818, ECO:0000269|PubMed:9493912}. Note=Associated with the nuclear matrix. {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:23385818, ECO:0000269|PubMed:9493912}.
Interaction partners:
- Histone acetyltransferase p300
- Histone deacetylase 1
- Histone deacetylase 2
- Histone-lysine N-methyltransferase EZH2
- RING1 and YY1-binding protein
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Polycomb protein SUZ12
- Chromatin-remodeling ATPase INO80
- Transcriptional repressor CTCF
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
Sequence:
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKSGKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ