wanglab/gogpt-training-data huggingface dataset:
Protein: Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) (P48018)
Organism: Bos taurus (Bovine)
Function: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}.
Interaction partners:
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 2
- Secernin-1
- Ras-related protein Rab-3A
- Syntaxin-1A
- Protein S100-A13
- Vesicular glutamate transporter 1
- Stonin-2
- Vesicle-associated membrane protein 1
- Syntaxin-1B
Sequence:
MVSESHHEALAAPPVTTVATVLPHNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK
Protein: Zinc finger CW type with PWWP domain 1 isoform 4 (A0A0S2Z5E1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSGLDFAETSCAQPVVSTQSDKEPGITASATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKKSNRLTLSKRKKEAQDEKVEKTQGGHEHRQEDRLKKTVQDHSQIRDQQKGEISGFGQCLVWVQCSFPNCGKWRRLCGNIDPSVLPDNWSCDQNTADVQYNRCDIPEETWTGLESDVAYASYIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQELSLELSVMKKRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNGSNSNGERKDLQLSGLNSPGSCLEKKEKEEELEKEEGEKTALRKNLKLPRARPWQPAFQREKKLEQCQRTWAYQRVRGPAPHLRKKSPDTGNP
Protein: NF-kappa-B essential modulator (C9JCG6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAED
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F8W562)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Programmed cell death protein 10-A
- TRAF2 and NCK-interacting kinase b.
- Cerebral cavernous malformations protein 2 homolog
- Krev interaction trapped protein 1
Sequence:
MAHLQNIRNQNSRLNPEEYFTKLERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLTGSKLWIIMEYLGGGSALDLLRPGTLEEVYIATILREILKGLDYLHSERKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNAELHPMRVLFLIPKNNPPTLEGSYSKAFKDFVEACLNKEPRFRPTAKELLKHKFITRYTKKTSYLSELIDRYRRWKSEGHGEESSSDDSDMDGEGDDRDQGPMWTFPTVRPSTINKLNRGLSHLDNKTSDVMKRQPKSSSLTSFITPIFKELKEKRRVGGNGVCAVEELENAFSLAEESSPGISDRLLNHVMERVCSFSGHADSML
Protein: Shikimate kinase 2, chloroplastic (OsSK2) (EC 2.7.1.71) (Q5NTH3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular location: Plastid, chloroplast {ECO:0000305|PubMed:15891897}.
Interaction partners:
- Chorismate synthase
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Os12g0534000 protein
- Chorismate mutase
- chorismate mutase
- Chorismate mutase
- Chorismate mutase
- Os06g0542200 protein
- Os06g0708832 protein
- Shikimate kinase 1, chloroplastic
Sequence:
MEARAGLAMQSRAAVGVGAGPGVGRRGRAVIRVGKRPTAASLRVGGPAGPAAAKPLAPLYCLKASRGHDSLHNSVDEALLLKRKSEEVLFYLNGRCIYLVGMMGSGKSTVAKILAEVLGYSFFDSDKLVEQAVGMPSVAQIFKEHSEAFFRDNESSVLRDLSSMRRLVVATGGGAVIRPVNWKYMKKGLSVWLDVPLDALARRIAQVGTASRPLLDQPSSDPYTAAFSKLSMLAEQRGDAYANADARVSLEEIAAKQGHDDVSKLTPTDIAIEALLKIENFVTEHSTSSGPVGDLIVDSQNRRTKAL
Protein: CRISPR-associated nuclease/helicase Cas3 (EC 3.1.-.-) (EC 3.6.4.-) (F2XG53)
Organism: Streptococcus thermophilus
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. Functions as a ssDNA-dependent ATPase; dsDNA, ssRNA do not stimulate ATPase activity, while other nucleotides (aside from dATP) are not hydrolyzed. Functions as a ssDNA nuclease; activity does not require ATP. Functions as an ATP-dependent helicase; helicase activity requires hydrolysable ATP. Unwinds both DNA/DNA hybrids and RNA/DNA hybrids, moving mostly in a 3' to 5' direction.
Interaction partners:
Sequence:
MKHINDYFWAKKTEENSRLLWLPLTQHLEDTKNIAGLLWEHWLSEGQKVLIENSINVKSNIENQGKRLAQFLGAVHDIGKATPAFQTQKGYANSVDLDIQLLEKLERAGFSGISSLQLASPKKSHHSIAGQYLLSHYGVDEDIATIIGGHHGRPVDDLDGLNSQKSYPSNYYQDEKKDSLVYQKWKSNQEAFLNWALTETGFNSVSQLPKIKQPAQVILSGLLIMSDWIASNEHFFPLLSLDETDVKNKSQRIETGFKKWKKSNLWQPETFVDLVTLYQERFGFSPRNFQLILSQTIEKTTNPGIVILEAPMGIGKTEAALAVSEQLSSKKGCSGLFFGLPTQATSNGIFKRIEQWTENIKGNNSDHFSIQLVHGKAALNTDFIELLKGNTINMDDSENGSIFVNEWFSGRKTSALDDFVVGTVDQFLMVALKQKHLALRHLGFSKKVIVIDEVHAYDAYMSQYLLEAIRWMGAYGVPVIILSATLPAQQREKLIKSYMAGMGVKWRDIENIDQIKIDAYPLITYNDGPDIHQVKMFEKQEQKNIYIHRLPEEQLFDIVKEGLDNGGVVGIIVNTVRKSQELARNFSDIFGDDMVDLLHSNFIATERIRKEKDLLQEIGKKAIRPPKKIIIGTQVLEQSLDIDFDVLISDLAPMDLLIQRIGRLHRHKIKRPQKHEVARFYVLGTFEEFDFDEGTRLVYGDYLLARTQYFLPDKIRLPDDISPLVQKVYNSDLTITFPKPELHKKYLDAKIEHDDKIKNKETKAKSYRIANPVLKKSRVRTNSLIGWLKNLHPNDSEEKAYAQVRDIEDTVEVIALKKISDGYGLFIENKDISQNITDPIIAKKVAQNTLRLPMSLSKAYNIDQTINELERYNNSHLSQWQNSSWLKGSLGIIFDKNNEFILNGFKLLYDEKYGVTIERLDKNESV
Protein: Orotate phosphoribosyltransferase 1 (OPRT 1) (OPRTase 1) (EC 2.4.2.10) (P13298)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Interaction partners:
- Dihydroorotate dehydrogenase
- Orotate phosphoribosyltransferase 2
- Orotidine 5'-phosphate decarboxylase
- Dihydroorotase
- Multifunctional protein URA2
- Pyrimidine pathway regulatory protein 1
- Ribose-phosphate pyrophosphokinase 3
- Ribose-phosphate pyrophosphokinase 5
- Ribose-phosphate pyrophosphokinase 4
- Ribose-phosphate pyrophosphokinase 1
Sequence:
MPIMLEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLFNTGKLLSNLATAYAIAIIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTDDKEGLSATQTVSKKYGIPVLSIVSLIHIITYLEGRITAEEKSKIEQYLQTYGASA
Protein: RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179) (Q9ULX5)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q96DY5}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q96DY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasm {ECO:0000250|UniProtKB:Q96DY5}. Nucleus {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96DY5}. Endosome {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q96DY5}. Postsynaptic density {ECO:0000250|UniProtKB:Q96DY5}. Perikaryon {ECO:0000250|UniProtKB:Q96DY5}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96DY5}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. {ECO:0000250|UniProtKB:Q96DY5}.
Interaction partners:
Sequence:
MPRPALSVTSFCHRLGKRERKQSFMGNSGNSWSHTPFPKLELGLGPQPMAPRELPTCSICLERLRDPISLDCGHDFCIRCFSTHRLPGCEPPCCPECRKICKQKRGLRSLGEKMKLLPQRPLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESGEGGRPRGGEASLQGCRWGANGLARGIWMWSHPFLLGKEGKKVAVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHPNKAGQGHVGNIFQRLSGRYPKVQELLQGKRARCCLLPAPGRRRMNQGHASPGDTDDDFRHLLGAYVSDVLSAAPQHAKSRCQGYWNEGRAVARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDVATKRIFSALRVLPDTMRNLLSTQKDAILARHGVALLCKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERLLEGDREPLLQEE
Protein: Oxidation resistance protein 1 (Q4ABH3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MVELIEIYWHMPTNEFSVIYHCRQQVPPTGVICSHLRPDGDSFEVFQQRAPKKHDPPRQKSSLPTIPTISYTVGNRDTLTSVAARFDTTPSELTHLNRLNSSFIYPGQQLLVPDKSAKDDASSSSTHDADGASLSGKSSPVERKLSGDESREKDILEGLRPGSPKPGHIERVGGSSQQQQAEEEANKSDDPVITQRFLKINVRHITDGQGVVGGVLLVTPNAVMFDPNVSDPLVIEHGPESYGVIAPMELVVNAAIFHDIAHMRVAGGAGQGLNSASGDAEKPEIYYPKPVLVEEDSKELPEQQSLLGEDGNKRLDAEIGSLEIADDQESLCSSTGRDGDAFPKAFDRERVEDSSMEAKDSAKTDALDDEDKKAGLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQDPHSANSSVSGVPLSQPPVAAAAAAAAVAPASAVVPLPPSGIDLEHLEQLSKQSCYDSGIDIREPVPNVQPIPKKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRSTILGQSLDAGTGGAGGVRKKTSSVSFSVDDEAAQQAQAQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSAPNTGDSNQSVFSKVFSRRSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPRPARACLDPPLYLRLRMGKPIGKAIPLPTSVMSYGKNKLRAEYWFSVPKNRVDELYRFINTWVKHLYGELDEEQIKARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRESWEVLSMSTDEYRKTSLFATGSFDLDFPIPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKVFHWTGENMYFIKGNMESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAFV
Protein: Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) (P49959)
Organism: Homo sapiens (Human)
Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:26215093}. Chromosome {ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30612738}. Chromosome, telomere {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:36050397}. Note=Localizes to DNA double-strand breaks (DSBs). {ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:36050397}.
Interaction partners:
- Serine-protein kinase ATM
- Breast cancer type 1 susceptibility protein
- BRCA1-associated RING domain protein 1
- DNA repair protein RAD50
- Nibrin
- Fanconi anemia group J protein
- DNA endonuclease RBBP8
- X-ray repair cross-complementing protein 6
- Exonuclease 1
- Flap endonuclease 1
Sequence:
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
Protein: Sensor protein kinase FleS (EC 2.7.13.3) (Q9I4N4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance. May function as a membrane-associated protein kinase that phosphorylates FleR in response to environmental signals leading to activation of specific gene promoters (Probable).
Interaction partners:
- Response regulator protein FleR
- Flagellar hook-basal body complex protein FliE
- Flagellar biosynthesis protein FlhF
- Flagellar M-ring protein
- Transcriptional regulator FleQ
- Antiactivator FleN
- Flagellar biosynthesis protein FlhA
- Flagellar protein FliL
- Flagella basal body P-ring formation protein FlgA
- Negative regulator of flagellin synthesis
Sequence:
MQPALNAFTEQPADTAEATSRAGLEQAFALFNQMSSQLSESYSLLEERVTELKGQLALVSAQRMEELAEKERLANRLQSLLDLLPGGVIVIDAHGVVREANPAALGLLGEPLVGMLWREVIARCFAPREDDGHEISLRDGRRLSIATRSLNGEPGQLILLNDLTDTRRLQEQLARHERLSALGRMVASLAHQIRTPLSAALLYAGHLSEQALPTDQQQRFAGRLKERLHELEHQVRDMLVFARGELPLTDRVAPKALFDSLRAAAEVHVQGLQVRWQCEARGGELLCNRDTLVGTVLNLVENAIQACGPELRLKVHLYARADSLRLSVSDNGPGMDPATLARLGEPFFTTKTTGTGLGLAVVKAVARAHQGQLQLRSRPGRGTCATLILPLIPAAPLSAIQE
Protein: Progesterone binding protein, putative (Q4WNM2)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
Sequence:
MVEHEQEPKRFEPKVPVQLDPPKDDPITMEELSKCDGTDPSRPTLVAIKGIVFDVSKNPAYGPNGQYRVFAGKDPSRALACSSLKPEDCRPDWYDLDDKEKTVLSEWFTFFSKRYNIVGKVKDATNY
Protein: Serine/threonine-protein kinase greatwall (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (Q95TN8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Endosulfine, isoform A
- G2/mitotic-specific cyclin-A
- Protein matrimony
- Monopolar spindle 1, isoform B
- Ovarian-specific serine/threonine-protein kinase Lok
- G2/mitotic-specific cyclin-B
- Cell division control protein
- Serine/threonine-protein kinase polo
- Germ cell nuclear acidic peptidase, isoform B
- Protein phosphatase PP2A 55 kDa regulatory subunit
Sequence:
MENADATSQSDVHIDYKTPKKTHSLIDSEQLLDKINILTTKPENHSQNAKLPTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNERPAAKEVQQMRHFACIDWENIGNTEPPFVPTPDNPTDTGYFDARNNLQHLQLSNFALEE
Protein: Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) (Q08705)
Organism: Gallus gallus (Chicken)
Function: Acts as both a transcriptional activator and repressor of the MYC gene.
Subcellular location: Nucleus {ECO:0000269|PubMed:8246978}.
Interaction partners:
- RAD21 cohesin complex component
- Stromal antigen 2.
- Uncharacterized protein.
- Structural maintenance of chromosomes protein
- Nucleophosmin
- Insulin-like growth factor 2
- Chitin-binding type-2 domain-containing protein
- BHLH domain-containing protein.
- Histone H3.3
- Histone H3
Sequence:
MEGEAVEAIVEESETFIKGKERKTYQRRREGGQEDEACHIAPNQADGGEVVQDVNSGVQMVMMEHLDPTLLQMKTEVMEGAVPQETEATVDDTQIITLQVVNMEEQPINLGELQLVQVPVPVTVPVATTSVEELQGAYENEVSKGGLQEGEPMICHTLPLPEGFQVVKVGANGEVETLEQGELQPQEDPNWQKDPDYQPPAKKTKKNKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMVMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCSGLDGGEGENGGETKKGKRGRKRKMRSKKEDSSDSEENAEPDLDDNEDEEETAVEIEAEPEVSAEAPAPPPSKKRRGRPPGKAATQTKQSQPAAIIQVEDQNTGEIENIIVEVKKEPDAETVEEEEEAQPAVVEAPNGDLTPEMILSMMDR
Protein: Snta1 protein (Q498T0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
Sequence:
QPRNLNEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDTLFLRAKDEASARSWAGAIQAQISTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYCSLPQTREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCNLSVHIDKGFTLWAAEPGATRAVLLRQPFEKLQMSSDDGMSLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA
Protein: Seminase (EC 3.4.21.-) (Q9VP95)
Organism: Drosophila melanogaster (Fruit fly)
Function: Seminal fluid protease which is required for cleavage and probably also activation of the metalloprotease Semp1. Also required for a number of female post-mating responses independent of Semp1 including egg laying and sperm usage.
Subcellular location: Secreted {ECO:0000269|PubMed:22253601}. Note=Secreted into seminal fluid. {ECO:0000269|PubMed:22253601}.
Interaction partners:
- Aquarius
- Uncharacterized protein, isoform B
- Seminal metalloprotease 1
- Accessory gland protein Acp36DE
- Lectin-46Ca
- AT03573p
- Accessory gland-specific peptide 70A
- Accessory gland-specific peptide 26Aa
- Uncharacterized protein, isoform A
- glutaminyl-peptide cyclotransferase
Sequence:
MKRLLFLFLLAGILINNHALQHNETIDLKKLAKIVLPPAYQTRVIGGRVTTNAKLGGYLVAMRYFNNFICGGTLIHELIVLTAAHCFEDRAEKEAWSVDGGISRLSEKGIRRQVKRFIKSAQFKMVTMNMDVAVVLLNRPMVGKNIGTLSLCSTALTPGQTMDVSGWGMTNPDDEGPGHMLRTVSVPVIEKRICREAYRESVSISDSMFCASVLGKKDACTYDSGGPLVYEKQVCGIVSFGIGCASRRYPGVYTDVHYVKPFIVKGIKALLSRSR
Protein: Sll0064 protein (Q55146)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Uncharacterized membrane protein sll0875
- Slr0876 protein
- Slr1098 protein
- ABC transporter
- ABC transporter
- Glutamine-binding periplasmic protein/glutamine transport system permease protein
- Uncharacterized WD repeat-containing protein sll0163
Sequence:
MLLKSAFTWLALTFTTGLVAIAPVQAETVLERVARTGELRAGTRTDAVPFGFEMANGEMEGYGVDLMALIALKLAEEMGKTITVDLDRVDLQSRFEAIASGELDIVCEATTITQDRLELVDFSAPFFISGAKFLMKQGSVEGFNINGTLEGIPIAYIQNTTTFDIIPKIYPLAQWVPVQDREEGIAKLDGGQVKAVVSDGILLVGELLKQGKNPAEYALGPYQPITTELYACILPQGDGDWKRFVDEVISSTENHDLLQEWFNIDQTNVVRVDPL
Protein: Protein male-specific lethal-1 (P50535)
Organism: Drosophila melanogaster (Fruit fly)
Function: The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B.
Subcellular location: Nucleus {ECO:0000269|PubMed:16543150}. Chromosome {ECO:0000269|PubMed:11014199, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:18510926}. Note=Msl-1 is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is also associated with 10-20 autosomal sites in males. {ECO:0000269|PubMed:11014199, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:18510926}.
Interaction partners:
- E3 ubiquitin-protein ligase msl-2
- Dosage compensation regulator mle
- Protein male-specific lethal-3
- Histone acetyltransferase MOF
- Chromosomal serine/threonine-protein kinase JIL-1
- Protein MBD-R2
- Reduction in Cnn dots 1, isoform E
- Protein will die slowly
- NuA4 complex subunit EAF3 homolog
- KAT8 regulatory NSL complex subunit 2
Sequence:
MDKRFKWPPKKRANYLESPYPHIPSRGRQRNLHGHPNQTQHLHQHPGKIYERQQYGNGRGGHGGGNNNYRKLLHSLPAEHGGGAMAPPSSGGTVCAGADMVKLISENNNLRRMVMLNLNLMQEQTDSIAAKDKELDDQSAKMSVVKAQNEELKQAVAQLEAANQELCKQLRRKNQRRNDNDDDDDDPPLPPAAPQQKLIRCHAETQTVFREREQGTQTIDAQPQFANALPRGINMKESPALDHHAGAVTNQPASKRSESKGRGEFNGKKVSTFILQRMNQDFEHHIHEQTEVAEEHEMEAHKEQISQEEDQLVAEEDHLHMQEVHTEEVVGGDIFHDALESIEMEVVTEELVDMEEHGQSVDANGHIEEDDDEDDEDDENSDKDDDSEEDDYPWMHSDADVNARTEEELWQNQNYLLELDPTEEKTCAPSAHSTPNHQQKSSTQAEIRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKEHESVPESPEVPKQQPHQEDAIVDHNAIKNQLEVPKPDLKPKDQPKDEQRQDGQLDVRVEPQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKTSSRESTLPKANTADIKDAPAQKVIANHQSTKTQTDPVKTQRLQVKIRQYEMHPDMRTGSSAPSDIRKQKNVDPVSTPETKTIKSKSMLVNDKKTTSETSQSPDQEIDVETVRRKLAEHLKKELLSQSHSSQVTLKKIRERVATNLIYPPPSAPVSSTTITPAPTPSTTPTPGSTPQHAVTSSMDQEISAAKSKSKAAEQIATPLTPQSNSSVSSTTSTIRKTLNNCSPHTYSKATARSGKLQSRFRTATFPYSTRTWEDQEFHCDNEFFLEEADELLADNPSLEIPKWRDVPVPPSSDKIDTELLSDATFERRHQKYVKDEVDRKCRDARYMKEQIRLEQLRMRRNQDEVLVALDPLRASTFYPLPEDIEAIQFVNEVTVQAFGENVVNMEARDDFGVPWVDAIEAPTSIARSKALAEPVATLASKKIPTTAAEARHQENHSSYVFPKRRKRQKNR
Protein: Pentatricopeptide repeat-containing protein At3g22150, chloroplastic (Q9LIE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Protein CLT2, chloroplastic
- Nicotinamide adenine dinucleotide transporter 1, chloroplastic
- Cationic amino acid transporter 6
- Large ribosomal subunit protein bL28c
- Plastid division protein CDP1, chloroplastic
- Plastidal glycolate/glycerate translocator 1, chloroplastic
- S-adenosylmethionine carrier 1, chloroplastic/mitochondrial
Sequence:
MAGSALPLPPPPPLSLQSPSQNQTRHSSTFSPPTLTPQTPSIRSRLSKICQDGNPQLARQLFDAIPKPTTVLWNTIIIGFICNNLPHEALLFYSRMKKTAPFTNCDAYTYSSTLKACAETKNLKAGKAVHCHLIRCLQNSSRVVHNSLMNMYVSCLNAPDCFEYDVVRKVFDNMRRKNVVAWNTLISWYVKTGRNAEACRQFGIMMRMEVKPSPVSFVNVFPAVSISRSIKKANVFYGLMLKLGDEYVKDLFVVSSAISMYAELGDIESSRRVFDSCVERNIEVWNTMIGVYVQNDCLVESIELFLEAIGSKEIVSDEVTYLLAASAVSALQQVELGRQFHGFVSKNFRELPIVIVNSLMVMYSRCGSVHKSFGVFLSMRERDVVSWNTMISAFVQNGLDDEGLMLVYEMQKQGFKIDYITVTALLSAASNLRNKEIGKQTHAFLIRQGIQFEGMNSYLIDMYSKSGLIRISQKLFEGSGYAERDQATWNSMISGYTQNGHTEKTFLVFRKMLEQNIRPNAVTVASILPACSQIGSVDLGKQLHGFSIRQYLDQNVFVASALVDMYSKAGAIKYAEDMFSQTKERNSVTYTTMILGYGQHGMGERAISLFLSMQESGIKPDAITFVAVLSACSYSGLIDEGLKIFEEMREVYNIQPSSEHYCCITDMLGRVGRVNEAYEFVKGLGEEGNIAELWGSLLGSCKLHGELELAETVSERLAKFDKGKNFSGYEVLLSNMYAEEQKWKSVDKVRRGMREKGLKKEVGRSGIEIAGYVNCFVSRDQEHPHSSEIYDVIDGLAKDMRGDSFLTTLPTVTPSLELDE