wanglab/gogpt-training-data huggingface dataset:
Protein: Pleckstrin homology domain containing, family A member 5 (A0A0N4SUY3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
YRPINVNSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHLEDAEPQNADIGRKLKRSEMLYTPEPNGMASEEVTEKERQKEQVHADGSCSEKSVPVS
Protein: Amastin (Q384H4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHGGANSAVASVHVDPTAQLQYNRQRGTEAYAECEYSDGSADENNRYPQRGQPPQTHETAAVSITDNRQQSNMTPRAHAGGTGGGGGGSTMRRNVINRFDYGIISPSDARSLFLGASLLNIFFAILGTSLSQLDEVGGACFTFWGYKTDCDSVSYTIRTQLLPCAPIRGRLQTGAAFSIISICLLASIIYLYIRSALAKYMSQYNAEGQTPARRMESRSGILPAEDSIVASNKWTIVAVGGVVVLCEVISWAMTISVYVSRFCEDASLDRNKVYGPGFALLIVGTLLFLMALVVFALRA
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38G42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MKARQIITHLAVLLLLVTPQARAAAPADGDNLATLAYLCPALQLADGDITLHPEQSNLDGSLQDLLALNMSLADAAWAAQFKASPPGATPVAATEQQQKQQAGTPEQIAAWTAAKANVDNTAKFKDVLAKYGYTQENASKLIPLKGPIAQYADAAFGIQQATKTSEKDDKTDSDLKALIKTAIYGHDGGYDATKKEEMGLQGTQNRENHCTAQSNSNPIQTISTMVACLCAVKDDMVSGKAPCGPHADATLKWQADGPPQTPLWPKIRSICPKADGGTVTADRIAAAIAAAKMAFFSKGNDLYVGKFDMAGCDGSNNGACIKYTDQASNSVPSFKQAAWIDKLETVETSLRTRQQNQDIQKQAQTKIETLKQLVKAAAKHAEKLTAPTTQHHSNPKLATTNDKNSQAQKTADCSKLEKAECKPDVGCRYNETTNKCEEDPKSPVVQANKEAKGGATNSEGKNYSGKKTEGECKDSCKWDGKECKDSIFLFRKKFFLIVFAFLVLLF
Protein: Heat shock protein 104 (Protein aggregation-remodeling factor HSP104) (P31539)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required, in concert with Hsp40 (YDJ1) and Hsp70 (SSA1) and small Hsps (HSP26), for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system. Substrate binding is ATP-dependent, and release of bound polypeptide is triggered by ATP hydrolysis. Also responsible for the maintenance of prions by dissociating prion fibrils into smaller oligomers, thereby producing transmissible seeds that can infect daughter cells during mitosis and meiosis. Loss of HSP104 can cure yeast cells of the prions [PSI+], [URE3] and [PIN+]. Excess HSP104 can also specifically cure cells of [PSI+].
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in an importin KAP95- and KAP121-dependent and an exportin XPO1-dependent manner. Accumulation in the nucleus is enhanced by severe heat shock. In the cytoplasm, concentrates on a perivacuolar compartment, the 'insoluble protein deposit' (IPOD), in which terminally aggregated proteins are sequestered. It is also found, to a lesser extent, at a 'juxtanuclear quality control' (JUNQ) compartment, where soluble ubiquitinated misfolded proteins accumulate.
Interaction partners:
- Eukaryotic peptide chain release factor GTP-binding subunit
- Mitochondrial protein import protein MAS5
- Heat shock protein 42
- Heat shock protein SSA1
- Protein SIS1
- Heat shock protein STI1
- Small glutamine-rich tetratricopeptide repeat-containing protein 2
- ATP-dependent molecular chaperone HSP82
- Heat shock protein 78
- Heat shock protein 26
Sequence:
MNDQTQFTERALTILTLAQKLASDHQHPQLQPIHILAAFIETPEDGSVPYLQNLIEKGRYDYDLFKKVVNRNLVRIPQQQPAPAEITPSYALGKVLQDAAKIQKQQKDSFIAQDHILFALFNDSSIQQIFKEAQVDIEAIKQQALELRGNTRIDSRGADTNTPLEYLSKYAIDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAIIEGVAQRIIDDDVPTILQGAKLFSLDLAALTAGAKYKGDFEERFKGVLKEIEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGQLKVIGATTNNEYRSIVEKDGAFERRFQKIEVAEPSVRQTVAILRGLQPKYEIHHGVRILDSALVTAAQLAKRYLPYRRLPDSALDLVDISCAGVAVARDSKPEELDSKERQLQLIQVEIKALERDEDADSTTKDRLKLARQKEASLQEELEPLRQRYNEEKHGHEELTQAKKKLDELENKALDAERRYDTATAADLRYFAIPDIKKQIEKLEDQVAEEERRAGANSMIQNVVDSDTISETAARLTGIPVKKLSESENEKLIHMERDLSSEVVGQMDAIKAVSNAVRLSRSGLANPRQPASFLFLGLSGSGKTELAKKVAGFLFNDEDMMIRVDCSELSEKYAVSKLLGTTAGYVGYDEGGFLTNQLQYKPYSVLLFDEVEKAHPDVLTVMLQMLDDGRITSGQGKTIDCSNCIVIMTSNLGAEFINSQQGSKIQESTKNLVMGAVRQHFRPEFLNRISSIVIFNKLSRKAIHKIVDIRLKEIEERFEQNDKHYKLNLTQEAKDFLAKYGYSDDMGARPLNRLIQNEILNKLALRILKNEIKDKETVNVVLKKGKSRDENVPEEAEECLEVLPNHEATIGADTLGDDDNEDSMEIDDDLD
Protein: Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Q9TRC7)
Organism: Sus scrofa (Pig)
Function: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis.
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:P19801}. Cell membrane {ECO:0000250|UniProtKB:P19801}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19801}; Extracellular side {ECO:0000250|UniProtKB:P19801}.
Interaction partners:
- Histamine N-methyltransferase
- Histidine decarboxylase
- Amine oxidase [flavin-containing] A
- Amine oxidase [flavin-containing] B
- Ornithine decarboxylase 1
- Spermidine synthase
- Aldehyde dehydrogenase family 3 member A2
- Aldehyde dehydrogenase 1A1
- Aldehyde dehydrogenase, mitochondrial
- 4-trimethylaminobutyraldehyde dehydrogenase
Sequence:
MGRGTLALGWAGAALLLLQMLAAAERSPRTPGGKAGVFADLSAQELKAVHSFLWSQKELKLEPSGTLTMAKNSVFLIEMLLPKKQHVLKFLDKGHRRPVREARAVIFFGAQEQPNVTEFAVGPLPTPRYMRDLPPRPGHQVSWASRPISKAEYALLSHKLQEATQPLRQFFRRTTGSSFGDCHEQCLTFTDVAPRGLASGQRRTWFILQRQMPGYFLHPTGLELLVDHGSTNAQDWTVEQVWYNGKFYRSPEELAQKYNDGEVDVVILEDPLAKGKDGESLPEPALFSFYQPRGDFAVTMHGPHVVQPQGPRYSLEGNRVMYGGWSFAFRLRSSSGLQILDVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHELAPDIDCPETATFLDALHHYDADGPVLYPRALCLFEMPTGVPLRRHFNSNFSGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRYGTRLHTHLIGNMHTHLVNYRVDLDVAGTTNSFQTLQMELENITNPWSPRHRLVQPTLKQTRYSRERQAAFRFGQPLPKYLLITSPKENPWGHTRSYRLQLHSMADQVLPPGWQEERAVTWARYPLAVTRYRESELSSSSIYNQNDPWDPPVVFEEFLRNNENIEDEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPALASRDLVVVWPLENGSTYAQRWIPEEDQSCLKPPPFSYNGSYRPV
Protein: FI05614p (Q0E8P5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Xenotropic and polytropic retrovirus receptor 1
Sequence:
MSRKMLQVPVATLVLLSLLPIAHVAAASATAADATAATAASTTSTGIDASLKNAKLIEAKVLPDLAILQRVNQEDEKWQQVYRFIDDGFPVLELYGYKPLPDLPYTLIVPKIDVRSIEKPRLKEFMLEHVVPGKIFDSYNGNGNSKEEEESFGNGNGHKIVFRKLEKSHNNVWLLNGQQILHKLRINENLMAIAIDGYLGDRKSPYSKRNIQETNNRYNDPQPLEQPNITNAHAKVEPVIKESKASPLMSFLANMKTGTKVFQHFLSKSNLTRIMDDNAYTVLIPSDNAFQRWHPIDWGFYPFSVPEFTESVLRNHFLPMQRPLRLADVRNMDEVVVTTMGGEDVVFHGQPTPTVNNVSIMSDYNLSNGNQVFIISEVLFVTEAVVSKLHQMHKDKETPPLLAFPWFGAQFLSHSFLALERDPRFTQITRYLNSAEIAPHISGANYTFFVPEDRAFEKQGFDKLSDEVMASQRGVKMLLNHFVKGRLYNRDLRDNEVFETIGGGHIKITRNPGSNYTSVNNAQITESEVFVYNLGTMYYLDDILYSHMLRDFVSKSTKTRSNRHGSDSGGGSRSTSRPSDVEIVPNEFEGEHNGGDYAIHGDDEDFEDEIITPKALPVQIYELPK
Protein: Pre-mRNA-splicing factor ini1 (Q9UTB8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:14762117}.
Interaction partners:
- Spliceosome-associated protein 49
- Splicing factor 3B subunit 6-like protein
- Uncharacterized protein C211.05
- Pre-mRNA-splicing factor prp12
- U2 snRNP component prp10
- Pre-mRNA-splicing factor sap145
- U2 snRNP component ist3
- Pre-mRNA-splicing factor sap62
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor sap61
Sequence:
MSKHHPDLVLCRRQPGITVGKLCERCDEKCPICDSHVRPTTLVRICDECAFGSSQDRCIICGAPGVSDCYYCSECTRMEYDRDGCPRVINLGSSRTDWFYERKKFKNAGKEMPGATY
Protein: Probable glycosidase crf1 (EC 3.2.-.-) (Crh-like protein 1) (allergen Asp f 9) (Q8J0P4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall.
Interaction partners:
- Endo-1,3
- Peroxiredoxin Asp f3
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Allergen Asp f 4
- Ribonuclease mitogillin
- Large ribosomal subunit protein P2
Sequence:
MYFKYTAAALAAVLPLCSAQTWSKCNPLEKTCPPNKGLAASTYTADFTSASALDQWEVTAGKVPVGPQGAEFTVAKQGDAPTIDTDFYFFFGKAEVVMKAAPGTGVVSSIVLESDDLDEVDWEVLGGDTTQVQTNYFGKGDTTTYDRGTYVPVATPQETFHTYTIDWTKDAVTWSIDGAVVRTLTYNDAKGGTRFPQTPMRLRLGSWAGGDPSNPKGTIEWAGGLTDYSAGPYTMYVKSVRIENANPAESYTYSDNSGSWQSIKFDGSVDISSSSSVTSSTTSTASSASSTSSKTPSTSTLATSTKATPTPSGTSSGSNSSSSAEPTTTGGTGSSNTGSGSGSGSGSGSSSSTGSSTSAGASATPELSQGAAGSIKGSVTACALVFGAVAAVLAF
Protein: Alkaline phosphatase (EC 3.1.3.1) (Q9VHD0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Thiamine pyrophosphokinase 1
- 6-pyruvoyl tetrahydrobiopterin synthase
- GTP cyclohydrolase 1
- IP06402p
Sequence:
MRLQLFFFLGLSVLVSGGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLGGEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAAQLINSPVGQKLNVIMGGGRENFLPKGVTDSSGAPGRRLDGRNLIDEWKNQHTNSAQYVENRRELLNLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMCVDGGVARRPR
Protein: Probable ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) (Q9UTI6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
- Choline kinase
Sequence:
MASSSNIKHRLWLDGCMDFFHYGHSNAILQAKQLGETLVIGIHSDEEITLNKGPPVMTLEERCLSANTCKWVDEVVPSAPYVFDLEWMRRYGCQYVVHGDDISTDANGDDCYRFAKAADQYLEVKRTEGVSTTELLDRLLSSVPLEIYSTPVSVLSSQIDLLRRFATDSDGLTPFTDVFIYNTEKPETLISGTTLLRLNPEKNIIYIDGDWDLFTEKHISALELCTRMFPGIPIMAGIFADEKCFEKPMLNLLERILNLLQCKYISSILVGPPPASLFASSKYIKLCFDEQISKVYYPIFSTDVSIPALDISLSNTPNNSFYKFDKLGSDLIKQRVMLRRQHYEERQRRKMGKNATEQTTIKTYA
Protein: G protein-coupled receptor kinase (EC 2.7.11.-) (F1R6F6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- ARF GTPase-activating protein GIT1 isoform X2
- Arrestin, beta 2a.
- Arrb2b protein
- Beta-arrestin-1
- ARF GTPase-activating protein GIT2a
- Chemokine
- C-X-C chemokine receptor type 4b
Sequence:
MELENIVANTVLLKAREGGGGKRKGRSKKWREILRFPHISQCTELNKAIERDYVCLCERQPIGRLLFRLYCETQPELQRCIQLLDAMDDYEVSPDEKRKSRGDEIIKKFLNKQSSECVDVAESLAERCKENLELSPCKEIFSDCRKALHDYLSGAPFTDYQNSMYFDRFLQWKMLERQPITKDTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNMGTPGFEKERVQLYAAEICCGLEDLHRESIIYRDLKPENILLDDNGHIRISDLGLAIKVPDGEQIRGRVGTVGYMAPEVINNERYSMSPDWWGLGCLIYEMTAGRSPFRARKERVKREDVEKRVQEEEEEYSDKFSEDTKAICRMLLSKDPKQRLGCQTDRASGVKAHPFFKNINFKRLEAGILEPSFVPDPRAVYCKDVLDIEQFSTVKGVNLDQTDNDFYSKFATGSVSIPWQNEMIETECFNDLNVFGPQGTRPPDLDWNQPPEPPRRSLLDRIFRRHVRISSTSTTEEHPREQSS
Protein: Mas-related G-protein coupled receptor member X3 (Sensory neuron-specific G-protein coupled receptor 1/2) (Q96LB0)
Organism: Homo sapiens (Human)
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-FMRFamide-related neuropeptide FF
Sequence:
MDSTIPVLGTELTPINGREETPCYKQTLSFTGLTCIVSLVALTGNAVVLWLLGCRMRRNAVSIYILNLVAADFLFLSGHIICSPLRLINIRHPISKILSPVMTFPYFIGLSMLSAISTERCLSILWPIWYHCRRPRYLSSVMCVLLWALSLLRSILEWMFCDFLFSGANSVWCETSDFITIAWLVFLCVVLCGSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGIQWALFSRIHLDWKVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDTPEVDEGGGWLPQETLELSGSRLEQ
Protein: Ras-related protein RabQ (Q55ET3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- Rac guanine nucleotide exchange factor B
Sequence:
MEEYHLKCIVTGPPFVGKSSLLLQFCEKEFSFEMDTTIGVEFQTRSILIDSSKIKLEIWDTAGQESFRSITTNYYRGAHIALLCYDITKRQSFQYLSGWMDEVRQMSSPNIVIALIGNKCDCKDKRVITTEEGAKNAKENDILFFETSAKDYESVESVFDGVSKKVLSLIKQGTLTVVNKKPQSIQLGAPTQETPKKPKSECCK
Protein: Cleavage and polyadenylation specificity factor subunit 6 (F8WJN3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR
Protein: CUGBP Elav-like family member 4 (K7ENR2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAAAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPF
Protein: Cytochrome P450 76M5 (EC 1.14.14.122) (Q6YTF5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Enzyme of the diterpenoid metabolism involved in the biosynthesis of the oryzalexin class of phytoalexins. Hydroxylates ent-sandaracopimaradien.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- 4-coumarate--CoA ligase
Sequence:
METRELWVLAAALAVSLLYYLAALMRYAGGGCSRSSRPPLPPGPTPLPLIGNLLSLRGVLHHRLASLARVHGPVMALRLGLTTAVVVSSRDAAAEAFTKHDRRLAARVVPDSNRAHGFSDRSIIWLPSSDPRWKALRGIQATHLFSPRGLAAVRSVRESKVRDIVAYFRSRAGEEVVFGEAIYSGVLNLVSSSFFSVNMAGVGSEEAHGLRELVEDLVEAIAKPNVSDLFPFLRQLDLQGLRRRTEERMARAFGILDGIIDRRLANRTHGDRHGDFLDALLDLVSEGKMARDHVTIMLFEVFGAGSDTMSVSLEWAMAELLRNPRAMRKARAELEDAAAVVEESDAARLPYLQAVVKEAMRLHPVGPILLPHRAVEDGVEIGGYAVPRGAMVIFNAWAIMRDPAAWERPDEFVPERFMETTTAIDFRGKEYEYLPFGSGRRLCPGLPLAERVVPFVLASLLRAFEWRLPDGVSAEDLDVSERFNTANVLAVPLKVVPVIVN
Protein: UDP-galactose transporter homolog 1 (Multicopy suppressor of leflunomide-sensitivity protein 6) (Q12520)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum. Overexpression confers resistance to the immunosuppressive drug, leflunomide.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11284010}; Multi-pass membrane protein {ECO:0000269|PubMed:11284010}.
Interaction partners:
- Putative nucleotide-sugar transporter YMD8
- Thiamine-repressible mitochondrial transport protein THI74
- UDP-N-acetylglucosamine transporter YEA4
Sequence:
MAGSTSSLVICAIGIYATFLTWALVQEPLATRTWPNSMGKFQFPNVISLIQASVAMMMGYLYLNWKKVEYPPRKMIKDHWKQLMLISFTQSSSGPLATTSLKHVDYLTYMLAKSCKMIPVLLVHLLLYRTPIASQKKVVALLVSLGVTIFTIGGNDGKKLKRSFNESGNDNKLQGFGLLFSSLFLDGLTNATQDKLLKANKAKEKGKQTLITGAHLMFTLNLFVILWNILYFIVIDCKQWDNAVSVLTMDPQVWGYLMLYSFCGAMGQCFIFYTLEQFGSLVLIMITVTRKMVSMILSIIVFGKSVRFQQWVGMFIVFGGITWEALNKKKANIPKAKSA
Protein: Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) (P00565)
Organism: Gallus gallus (Chicken)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable).
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MPFSSTHNKHKLKFSAEEEFPDLSKHNNHMAKVLTPELYKRLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKDLFDPVIQDRHGGYKPTDKHRTDLNHENLKGGDDLDPKYVLSSRVRTGRSIKGYSLPPHCSRGERRAVEKLSVEALNSLEGEFKGRYYPLKAMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLKKIEEIFKKAGHPFMWTEHLGYILTCPSNLGTGLRGGVHVKLPKLSQHPKFEEILHRLRLQKRGTGGVDTAAVGAVFDISNADRLGFSEVEQVQMVVDGVKLMVEMEKKLEQNQPIDDMIPAQK
Protein: Metal-binding protein ZinT (Cadmium-induced protein ZinT) (P76344)
Organism: Escherichia coli (strain K12)
Function: May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2+) over Cd(2+). Contains one high affinity metal binding site, and can bind additional metal ions at other sites.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12480884}. Periplasm {ECO:0000269|PubMed:12480884}. Note=Cytoplasmic in nonstressed cells, and exported to the periplasm upon exposure to cadmium.
Interaction partners:
- High-affinity zinc uptake system protein ZnuA
- Large ribosomal subunit protein bL31B
- Zinc import ATP-binding protein ZnuC
- High-affinity zinc uptake system membrane protein ZnuB
- Zinc transporter ZupT
- Inhibitor of g-type lysozyme
- Cytochrome b561 homolog 1
Sequence:
MAIRLYKLAVALGVFIVSAPAFSHGHHSHGKPLTEVEQKAANGVFDDANVQNRTLSDWDGVWQSVYPLLQSGKLDPVFQKKADADKTKTFAEIKDYYHKGYATDIEMIGIEDGIVEFHRNNETTSCKYDYDGYKILTYKSGKKGVRYLFECKDPESKAPKYIQFSDHIIAPRKSSHFHIFMGNDSQQSLLNEMENWPTYYPYQLSSEEVVEEMMSH
Protein: AP3D1 protein (Q6PK82)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAREAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKKKKKKKKKKKKKKKKKKK
Protein: carboxylesterase (EC 3.1.1.1) (A0A0B4K6V8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMSKESSLETCELTLPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTREIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKLQIWDNLYKPNQLI
Protein: Large ribosomal subunit protein eL21 (60S ribosomal protein L21) (Q54X53)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL34
Sequence:
MPHSFGLRARTRYLFSRGFRNHGLLQTTTFLRTFRLGDYVDIKATGNVHKGMPHKFYHGRTGRVWNVTPRAVGVIINKRVGPRIIAKKIHVRTEHVKPSNSMAAHLKRIQENKKAVVEAKKAGKWVDVRRNPAAPKDGFFVNPRNTEFVEVKPVKYELLL
Protein: NADPH-dependent conjugated polyketone reductase C1 (CPR-C1) (EC 1.1.1.-) (2-dehydropantolactone reductase) (EC 1.1.1.358) (Ketopantoyl-lactone reductase) (Q76L37)
Organism: Candida parapsilosis (Yeast)
Function: NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. Reduces ketopantoyl lactone and isatin. Does not act on menadione, p-nitrobenzaldehyde and pyridine-3-aldehyde.
Interaction partners:
Sequence:
MSLAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGTNKEIGIALKNVGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLEYVDLYLIHFPYISEKSHGFDLVEAWRYLERAKNEGLARNIGVSNFTIENLKSILDANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRPGPLDKVLSKLSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDFELDKEDEDQITKVGKEKTLRQFSKEYSKYD
Protein: Uncharacterized protein (Q57YG9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Pre-mRNA splicing factor, putative
- MI domain-containing protein
- Splicing factor YJU2
- Pre-mRNA-splicing factor U5-Cwc21
- Pre-mRNA-splicing factor SLU7
- RNA helicase
- Peptidyl-prolyl cis-trans isomerase
- Cell division control protein, putative
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
Sequence:
MGPKKAGGGDSTATFPLAPVGTFECNARCCCVVGKVVWVAELKGGVAVHNAQDGQLLERIAVAEGNNRVHFKCMVLVNHELWAGSSEGVVHIFEATRRRWKRQIAIMGTGTAAPITALIFDGHSVIGASETGRIVQWNPSSKAQMMAYTSSSPAADVTVFAGLIISGHGDGSLRVWDPYSGEMVVEHLKDNSDVTRLLVEPTTSTLWVGRRSGCISVYSLDAESEERRSLEPVLFTLKSRVLIGKEAVTSLQAITGKVLVTTHCRVVAVVNAHTYEVLIRVNGAHDAFIYGAARVYVAETVRAWTIGNDSVAHIWDVAGYYVPSQSTPAMGPHEQEKIVEDAKCLLSFENSKLATRVAAAGVTVTKLQEELQAARNEAQELRLRLVSVDDLEKEKEVEIVSSSTRIKELESEVKRLNKELADANARADGAERQFNMTRNDLNNAATEASKARADVSEKIKEKADVEQQLAARNTEKLHLERQLRDKSLELEHVRGEYDRLHRATAQGLQTKGVTDAYKFCSSRDGGVALSNELEELRKKNELLGTLLSSMEYTLRRKEEEERDMAVLLNGFRRKLADKVVDPHLIALLNATMLNNPDKFYISDDEGTKSALLERNGPLSRYLQSLRDCDPDVYEQLLAYLQHPLAGSTNDPIYDKLMLLARDEGETAENFSFLKKTLPILLSSVNFMNAASGVETGDFHPTPSGTITAKQMDETPGNALNTVVGSIVDATTRNSSENKPSVEDPLFGVLKNLQLFGDINILTGQTNPSANDEAYLKQVRNTFEFILQTRSSLVKQLALLSKRVAKGLQVVTALASKNTRDGITQGGRPVSFNASGGTSSRGNSLGAVAVGILEELNSVVTVIVSSFLTLNEKQRVGVGTQF
Protein: Segmentation protein Runt (P22814)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a pivotal role in regulating the expression of other pair-rule genes such as eve, ftz, and h.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399, ECO:0000269|PubMed:2249771}.
Interaction partners:
- Protein big brother
- Zinc finger protein 2
- Tyrosine-protein kinase Src64B
- Protein groucho
- Protein brother
- Protein tramtrack, alpha isoform
- Histone deacetylase HDAC1
- P53, isoform B
Sequence:
MHLPAGPTMVANNTQVLAAAAAAAAAAAAAVAQGPGPQQSSNATTASAIAINPAQSLANTSTHSASSTGSSTPDLSTNNTSSSSNATTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSYGYPHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATSSSSAVQPSEYPHPAAAVAAAAGQPAAMMPSPPGAAPATPYAIPQFPFNHVAAAAAAKAATPHAFHPYNFAAAAGLRARNAALHHQSEPVHVSPASSRPSSSSPTQQHVLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRMRCDLKAPSAMKPLYHESGPGAVANSRQPSPETTTKIKSAAVQQKTVWRPY