wanglab/gogpt-training-data huggingface dataset:
Protein: Protein transport protein Sec24A (SEC24-related protein A) (O95486)
Organism: Homo sapiens (Human)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000305|PubMed:17499046}; Peripheral membrane protein {ECO:0000305|PubMed:17499046}; Cytoplasmic side {ECO:0000305|PubMed:17499046}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:17499046}; Peripheral membrane protein {ECO:0000305|PubMed:17499046}; Cytoplasmic side {ECO:0000305|PubMed:17499046}. Cytoplasm, cytosol {ECO:0000305|PubMed:17499046}.
Interaction partners:
- Protein transport protein Sec23A
- Protein transport protein Sec16A
- Protein SEC13 homolog
- Protein transport protein Sec23B
- Protein transport protein Sec24D
- Protein transport protein Sec31A
- Small COPII coat GTPase SAR1A
- Protein transport protein Sec24C
- Small COPII coat GTPase SAR1B
- Vesicle-trafficking protein SEC22b
Sequence:
MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSYYEFLLHIQQQVNK
Protein: AT4g34920/F11I11_160 (PLC-like phosphodiesterases superfamily protein) (Q9SW43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase CYP21-1
- Probable magnesium transporter NIPA6
- MAP3K protein kinase-like protein
- Dirigent protein 15
- PEARLI 4 protein family protein)
- Protein MANNAN SYNTHESIS-RELATED 2
- Protein MANNAN SYNTHESIS-RELATED 1
- Non-specific phospholipase C3
- Phosphoinositide phospholipase C 6
- Phosphoinositide phospholipase C 5
Sequence:
MLSFFSNQIDRQKDVSNEEKTLTNLEKSDGSQFPGDDYRPSDRKNWMAGLTLEKLTLNKIVWPGTHDSATNDIGIPLISRPLAECQSLSIYEQLVLGTRVLDIRVQEDRQICHGILTSYEIDVVIDDVIRFLSETHSEIVILEIRTEFGHKDPPGFETYLADKLGQFLIHQDDSLFNKPVSEILPKRVICIWKPRESPKPSRGGILWNSDYLKDNWIDTDLPWTKFQSNLKHLSEQQPTSSRKFFYRVENTVTPQADNPVVWVKPVTDRIRKHARLFISQCVSKGCGDKLQILSTDFIEGDFVDACVGLTHARIEGKV
Protein: Homeobox protein Hox-C9 (Homeobox protein Hox-3.2) (P09633)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-C6
- Homeobox protein Hox-C10
- Pre-B-cell leukemia transcription factor 1
- Pre-B-cell leukemia transcription factor 3
- Transmembrane protein 26
- Pre-B-cell leukemia transcription factor 2
- Homeobox protein Hox-B7
- Homeobox protein Hox-C4
Sequence:
MSATGPISNYYVDSLISHDNEDLLASRFPATGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSVVYHPYGPQPHLGADTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPGRRADCGPGDGRSYPDYMYGSPGELRDRAPQTLPSPEADALAGSKHKEEKADLDPSNPVANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQNRRMKMKKMNKEKTDKEQS
Protein: Uncharacterized protein (Q381V2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLLLDDDDEYNPPTKVMRTEPVMADSMLHNGVPVERTNVIAEGNSSAAELNIARRGGDGVEKMAAFAFAAGVVKVNLVDRLDHPSPSGATTTTTTATTSQEQTPSTCFRGNNPPTVPKVVKGDVSPSSQHGSSALLSPFSGSPDHPSSTDIMENNNDSTSAVPTVCELFPQGDAIKSGISGVGNTTPTGKSPLRAQGGIPTPPKSQMKLSDFFAKMACVRKM
Protein: Protein RFT1 homolog (Q383B3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365067}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365067}.
Interaction partners:
Sequence:
MDFKRQLASALVLNVVLKVFTFLLTAGVTRQLAPNENGVNFSFQLYFNTVLFLARESVRSVNARHNLREKSGSGGAALKVMNCAAISLPLGLLVVLVLELLHGFRITLFPSLAALANVGSVSAASAEAQGPGMDGGTLGLPEVVQVISVIAALSIEPCLAVAQSLDNVRTVVTSEFWALLARLTATISILWWYGSLSGHPWITRMCFSVANLSDALATVAYFLCLWNAPNQERGRKAAGGGGCEGDEDGEAATSMYQVRVIAARVLWGDTVQTKTSARSHPLRECLPWCYLSLHSMHDVLLREFRLFLQFFRESCLRLLLTEGEHFALAAMGSAAAVGQYSVVTNLGSLIVRLVFRVWETACFARWSRDIAAGRMADASVLLFVMLRVSLYFGAVAILLGPPLAELVLLRLFTRRWATAETVRALQLYCYQLPLMGWYGLLDAFVRATASPRVLRLAQQVLVVQAAVYVAFCFAALRLHWVGDPVAGLIVANGISTGLRCATSLWMIIKTPGRPQQESRRFEVQLRDFSAVFDSRIATVWFLLFGCTRMLLPFISLTTSGVVSVVLFFPLFAASVLRWDPETRVVVKALVLSSKRSGE
Protein: Calponin-homology (CH) domain-containing protein (Q8BYJ2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPAILVASKMKSGLPKPVHSAAPILHVPPARTGPQPCYLKLGSKVEVSKTAYTSQIPLKSQGLQEPTGEGLPLLKSSSLENGFDTQIYTDWANHYLAKSGHKRLIKDLQQDVTDGVLLAQIIQVVANDKIEDINGCPKNRSQMIENIDACLNFLAAKGINTQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQQQQQPEKQPLSSSPLPPAGSQVAGAPSQCQAGTPQHQGLATPQAPCQLLQPVSHQQGKTQVEMQSRWAPLRDRWRCRPIFRCPSSQLCREPVCSVVLICEELAWPQDR
Protein: Claudin (Q98SR1)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell junction, tight junction {ECO:0000256|RuleBase:RU060637}. Cell membrane {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU060637}.
Interaction partners:
- Tight junction protein 1
- Cadherin-5
- Uncharacterized protein
- Uncharacterized protein.
- Claudin
- Claudin 12
- Platelet and endothelial cell adhesion molecule 1.
- Claudin
- Uncharacterized protein.
- Uncharacterized protein
Sequence:
MASAAVEILGLGLGILGWVGVILACGLPMWQVSAFIDVNIVVAQTIWEGLWMNCVVQSTGQMQCKVYDSILALRPEVQAGRALTVIVALLGLVALMVTVVGAQCTNCIRPGKMKSRIVIAGGTIYILCGVLVLVPLCWFANIVISDFYDPSVPPSQKREIGAALYIGWAATALLLFGGCLICCCSCLQRDETSFPVKYSAPRRPTSSGEYDKKNYV
Protein: Fibronectin binding protein (Q53971)
Organism: Streptococcus dysgalactiae
Interaction partners:
Sequence:
MKNKVLKTLVLFLFAVLGIFSIQTVRAAGKSVNLQVKAQTEQINHGDSVRFEVNFGGPGTKVEKNQTVNISFIGDYAKINLPKESLILKDSNDDAILGRVEFSDNKAILIFNEEASHRDDIVGGFFFDARGIYNGDVKSSGKGSIRVEYENKYRIININYNAGGSRTDSVYAKSGVLDDFDSTGRIVNWYFNFNAALNPIKDEDVEFMTTDNLPQTMTWDIEAVKKDPYVVQIRGGYLGTVFSKNGGWIDIEEATKLGIEIIFSGQKLTIKIPKWTNYNGLIPYVKPLNQTSISVKLTAKITEKTMRDQTIEYVENDSIPKIEGIEWNLDKNQFGAKVRIQRSGSWILGVRPGDLKVLKFERDKSKAIPKVKFRLIREDNHEIEAKMGKESYQNLGRFYDFETGEDGSVTLKGLKDGIYLLKEIGNNLVDLSKPIVWDNLSLREKIELNQEQPYKVIISSTQQPNGIVLKVENELKSEKVDIKVTKKWEDYQDKFKKRPDHILLDLEANGEKVEGHTSKIVTKGMDDKWSYTFKDLPKYNDRGEKISYKVVEVQVNEYETPIIEEISPYNFTITNKYINKETTELSGKKIWENDRANQRPEQIQVQLLQNGQKMPNKIQEIKANDWTYKFKDLPKYDETGKEYKYSVEEVTVPDGYKVSYLGNDIYNTRETEFIFENNNFSLEFGNSEVKGQSGSKVITEDTLTSFKGRKLWKNDAATDRPEAIQVQLYADGVAVEGQTKYVSGSGDEWSFEFKNLKKHGESGKEIVYSVKEVTVPAGYDVTYSDNDIINTKREVIIQQGPILGLEETLPTEEHQSGDTTTIEDTRPIDTMSGLSGETGQSGNTTIEEDSTTHVKFSKRDINGKELAGAMIELRNLSGQTIQSWISDGTVKVFYLMPGTYQFVETAAPEGYELAAPITFTIDEKGQIWVDSTLIVGDDPIVMIDNDKPITEASQSIDFEETLPTEQGQSGSTTEVEDTKGPEVIIGGQGEIVDIEENLPTEQGQSGSTTEVEDTKGPEVIIGGQGEVVDIEESLPTEQGQSGSTTEVEDSKPKLSIHFDNEWPKEDKPQLPAVEKPKTKESLPAAGEAEHVLSTIVGAMILFLVSLWGLLKRKASKA
Protein: Uncharacterized RING finger protein P8B7.15c (O94264)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Polyadenylation factor subunit 2
- Protein cft1
- Cleavage factor two protein 2
- Endoribonuclease ysh1
- mRNA 3'-end-processing protein yth1
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- Poly
- Pre-mRNA polyadenylation factor fip1
- Set1 complex component swd2
Sequence:
MSGVIYYKFKSQKDPSRITFDGTIGMSVFDVKREIIMQKKLGNGLDFDLLLYNANSNEEYDDDTFIIPRSTSVIVRRVPAQKSGKGTAARYVSGAPKTTGARSDSVKRPVPMLQKKAPITSGESNINKSPSSSEDAAIQQMFQVSSDQWRETQDKMASATPIYKPNQRRIAASVPDKPPPPGYICYRCGQKGHWIQACPTNADPNYDGKPRVKRTTGIPRSFLKNVERPAEGDAANIMINAEGDYVVVQPDVASWETYQSRKAALTANDVYKMQPPNISLACTLCKKLARNACRTPCCDKLFCEECIQTALLDSDFECPNCHRKDVLLDTLNPDYQKQREIEAVVKSVLGSNSKNSDKVGTSDDNNTPMSEKRKREDDDANGPNKFAARSSAVFSKATAEPAFKSAMAIPDMPSMPHVQGFPAPFPPFMMPGLPQMPPMMMNAIAGQVYHNNRNPPRTNSRPSNASVPPPSSLHKNPPTKTN
Protein: Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) (Q96K21)
Organism: Homo sapiens (Human)
Function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24814515}. Cleavage furrow {ECO:0000269|PubMed:24814515}. Midbody, Midbody ring {ECO:0000269|PubMed:24814515}. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. {ECO:0000269|PubMed:24814515}.
Interaction partners:
- Vacuolar protein sorting-associated protein 4A
- Vacuolar protein sorting-associated protein 4B
- Charged multivesicular body protein 4c
- Charged multivesicular body protein 1b
Sequence:
MNYDSQQPPLPPLPYAGCRRASGFPALGRGGTVPVGVWGGAGQGREGRSWGEGPRGPGLGRRDLSSADPAVLGATMESRCYGCAVKFTLFKKEYGCKNCGRAFCSGCLSFSAAVPRTGNTQQKVCKQCHEVLTRGSSANASKWSPPQNYKKRVAALEAKQKPSTSQSQGLTRQDQMIAERLARLRQENKPKLVPSQAEIEARLAALKDERQGSIPSTQEMEARLAALQGRVLPSQTPQPAHHTPDTRTQAQQTQDLLTQLAAEVAIDESWKGGGPAASLQNDLNQGGPGSTNSKRQANWSLEEEKSRLLAEAALELREENTRQERILALAKRLAMLRGQDPERVTLQDYRLPDSDDDEDEETAIQRVLQQLTEEASLDEASGFNIPAEQASRPWTQPRGAEPEAQDVDPRPEAEEEELPWCCICNEDATLRCAGCDGDLFCARCFREGHDAFELKEHQTSAYSPPRAGQEH
Protein: La-related protein 7 (La ribonucleoprotein domain family member 7) (Q9W362)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Hexamethylene bisacetamide inducible, isoform B
- LD40489p
- Cyclin-dependent kinase 9
- Cyclin-T
- LD31543p
- 7SK snRNA methylphosphate capping enzyme bin3
- Serine-arginine protein 55
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MAAKSIEKEKGEGQEPATSAEKPDPAAPTEPAEENSKEPAPEDASPDKKDGGRKRKRHLFNSIRGQMEFYFGDANLSKDRFLRRYVEQDPYVPLEIFLTFNKIKTLTQDVQQIAKALSNSQLLELDETELKVKRRTKLPDQRDVNDKTLYVEALPANATHDWLKEVFSRYGPVAYVSLPHYPGTKKIKEFAFIEFEKSGSLEKAVKAFAQIQGVLSVETDPSDLASVRSFQQQQQIQQKAEQPQSEAEQVELPKRNLKREATDKDREEIHEVKRVKLEEGQPSETSTAGETASETDAEGTAEASEQEDKTEATDGDEAAKKRRRKRKKKAIVDKPNIEPSALELKVLPKTSWSSMRNKYLNLQRRIVSEAKSKLWRENHPQNQQHPHHQQTSHPNHPKPSQLPEAVKEEETGGEVPSDGGEGAVEAAPVPAKRRKAVHKMNMNFYGAGGVESTKSEEPSQERTPLFKYEPGLIVECSLLKPCTNVKEFKAEMRQYPDIKYVDIKEGDQVALLRLGTPAAAEELLRQVNCSERQLKVLSGQQETLYWRKIEQDREAKLSKKVRVQQKRGREKVGKMLGKHIKFDDGDDEVQAAAMD
Protein: D-xylose-proton symporter-like 3, chloroplastic (Q0WWW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- ADP,ATP carrier protein 2, chloroplastic
- ADP,ATP carrier protein 1, chloroplastic
- Protein CLT2, chloroplastic
- Protein TIC 20-II, chloroplastic
- Dicarboxylate transporter 2.2, chloroplastic
- Sorbitol dehydrogenase
Sequence:
MAFAVSVQSHFAIRALKRDHFKNPSPRTFCSCFKSRPDSSYLSLKERTCFVSKPGLVTTRYRHIFQVGAETGGEFADSGEVADSLASDAPESFSWSSVILPFIFPALGGLLFGYDIGATSGATLSLQSPALSGTTWFNFSPVQLGLVVSGSLYGALLGSISVYGVADFLGRRRELIIAAVLYLLGSLITGCAPDLNILLVGRLLYGFGIGLAMHGAPLYIAETCPSQIRGTLISLKELFIVLGILLGFSVGSFQIDVVGGWRYMYGFGTPVALLMGLGMWSLPASPRWLLLRAVQGKGQLQEYKEKAMLALSKLRGRPPGDKISEKLVDDAYLSVKTAYEDEKSGGNFLEVFQGPNLKALTIGGGLVLFQQITGQPSVLYYAGSILQTAGFSAAADATRVSVIIGVFKLLMTWVAVAKVDDLGRRPLLIGGVSGIALSLFLLSAYYKFLGGFPLVAVGALLLYVGCYQISFGPISWLMVSEIFPLRTRGRGISLAVLTNFGSNAIVTFAFSPLKEFLGAENLFLLFGGIALVSLLFVILVVPETKGLSLEEIESKILK
Protein: Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Q90WY4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MICGANATNGTNATKEYTLLVALPLSIAVGLLILLIIFGNVLVIIAVFTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDRYWSITQAIEYNLKRTPQRIKRIIFIVWIIAAVISCPPLITMKKSEGDICDINKEKWYIVSSCIGSFFLPCIIMVLVYIRIYQIAKKRTRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPDDKDEINGVDMEESSSSDHKVSNPCSLKKKSSKGKTKLSQIKPGDGDKTEACQTTKASRWKGRQNREKRFTFVLAVVIGVFVICWFPFFFTYTFTAFCDCCVPETLFKFFFWFGYCNSSLNPIIYTIFNNDFRRSFKKILCRRDKRRVV
Protein: Pyridoxal phosphate phosphatase YbhA (PLP phosphatase) (EC 3.1.3.74) (P21829)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the dephosphorylation of pyridoxal-phosphate (PLP). Can also hydrolyze erythrose-4-phosphate (Ery4P) and fructose-1,6-bis-phosphate (Fru1,6bisP).
Interaction partners:
- Molybdenum transport system permease protein ModB
- Molybdate-binding protein ModA
Sequence:
MTTRVIALDLDGTLLTPKKTLLPSSIEALARAREAGYQLIIVTGRHHVAIHPFYQALALDTPAICCNGTYLYDYHAKTVLEADPMPVIKALQLIEMLNEHHIHGLMYVDDAMVYEHPTGHVIRTSNWAQTLPPEQRPTFTQVASLAETAQQVNAVWKFALTHDDLPQLQHFGKHVEHELGLECEWSWHDQVDIARGGNSKGKRLTKWVEAQGWSMENVVAFGDNFNDISMLEAAGTGVAMGNADDAVKARANIVIGDNTTDSIAQFIYSHLI
Protein: Protein ste6 (P26674)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating.
Interaction partners:
- Ras-like protein 1
- Protein csh3
- GTPase-activating protein
- Protein kinase byr2
- GTP-binding protein rhb1
- Sexual differentiation protein ste4
Sequence:
MRFQTTAISDYENSSNPSFLKFSAGDTIIVIEVLEDGWCDGICSEKRGWFPTSCIDSSKIQNFFSSFHSSNEKDPNAQCCAPFHVEAHLQDSAWFEKHGVQAINSIPSSEEFLRKNLQNDIHHLVKGILTTAAAVSQSIKKEGTQVIVFGIETVRSMVLSFPLIILSTLDENFLSEVAQVFSSLNLLPELSRMGCTYGELCIRFTKLLKQLANKFLFFFRPDVSFPSYFLGSLIAHEIHFLPWDFNMLCSNSVQSAHTNLQPDITSFVAILSLSHEAYHCTENEFWNLEAQKLTENTTQKVLQLVAEDALEAWKLDILEDIDRCIQCCRRFLSANQRINYSSSENNPFSFTSQDVEALKDELSSNLCDLYLWSIDLEQISPSDCLLDNYSLFVDLLVTLKVSLLRIKSIIVQFSERIVFLSLEYKFLTNIQPELNDAEKSQLDGFDLNKTNWFDSKGLVCYLMKQTSPEPLLIRNLLFSFWSCNGKIEQDGKIKTATLVFIINYLLRTDIDSTFFTTIFLNTYASMISSSDLFSILGAHFRFICSLNFGKISFISHEFYRVSKRFLDILLIWFESYLVEELDNSKSIFFLFKIYKVFEVFVVPHFASAEELLHSLSHLLHHPSTKRSHKMLEGKELSQELEDLSLHNSPDPIIYKDELVLLLPPREIAKQLCILEFQSFSHISRIQFLTKIWDNLNRFSPKEKTSTFYLSNHLVNFVTETIVQEEEPRRRTNVLAYFIQVCDYLRELNNFASLFSIISALNSSPIHRLRKTWANLNSKTLASFELLNNLTEARKNFSNYRDCLENCVLPCVPFLGVYFTDLTFLKTGNKDNFQNMINFDKRTKVTRILNEIKKFQSVGYMFNPINEVQELLNEVISRERNTNNIYQRSLTVEPRESEDQALQRLLIDSGIF
Protein: Serine/threonine-protein kinase shk1/pak1 (EC 2.7.11.1) (P50527)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11972773}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11972773}. Note=Localizes at cell ends, septum forming regions and at the mitotic spindle.
Interaction partners:
- Cell division control protein 42 homolog
- Protein scd2/ral3
- Protein kinase byr2
- Protein arginine N-methyltransferase skb1
- Probable Rho-type GTPase-activating protein 4
- Rho guanine nucleotide exchange factor scd1
- Ras-like protein 1
- Checkpoint signal transducer rad24
- Guanine nucleotide-binding protein subunit beta
- Shk1 kinase-binding protein 5
Sequence:
MERGTLQPRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRSYDERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPAPTPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHIRPNNSTPYQRRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIKSIHHSGK
Protein: Caspase 6-like protein BG2 (Q9NHF9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDDTDFSLFGQKNKHKKDKADATKIAHTPTSELDLKRVIISRPTNEDTYENCARAGIALILNHKDVKGQKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAREDHSQNDCFVLAVMSHGTEGKVYAKDMSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTKTFQLRVKPKT
Protein: Tetratricopeptide repeat domain 39A (A0A0A0MRQ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSAGGAPGALPAGTPESSLHEALDQCMTALDLFLTNQFSEALSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLLQRAALTFLQGSSHGGAVRPRALHDPSHACSCPPGPGRQHLFLLQDENMVSFIKGGIKVRNSYQTYKELDSLVQSSQYCKGENHPHFEGGVKLGVGAFNLTLSMLPTRILRLLEFVGFSGNKDYGLLQLEEGASGHSFRSVLCVMLLLCYHTFLTFVLGTGNVNIEEAEKLLKPYLNRYPKGAIFLFFAGRIEVIKGNIDAAIRRFEECCEAQQHWKQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATYIYMKAAYLSMFGKEDHKPFGDDEVELFRWVPHRAPTV
Protein: Elp3/MiaA/NifB-like radical SAM core domain-containing protein (Q9A5W5)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Type-4 uracil-DNA glycosylase
Sequence:
MLDMAVLDLRRKLAILSDAAKYDASCASSGAVQRNSLNGKGVGSTEGMGICHAYAPDGRCISLLKILLTNFCIYDCAYCINRISSNTPRARFTVQEVVDLTLNFYKRNYIEGLFLSSGVIRSGDYTMEEMVRVAKSLRLDHDFRGYIHLKLIPEASPELAAEAGLYADRVSINIELPRDDSLKALAPEKDPTDIKRAMGRMRLAIDDHAEPGRKARRRAFARSQSTQLIVGADEAKDGDILSRSANLYGAYRLSRVYYSAFSPIPDASHRLPLVRPPLLREHRLYQADWLMRFYGFAQSEIVAAGQDLDLSVDPKTSWALRHRDRFPVDVQIADKETLLRIPGLGAKAVARVLVARRVTRLTLDDLKRVGAVVKRAKPFVVTADWRPGALTDRDDLKAVLSPAVQLSLF
Protein: Aldehyde dehydrogenase domain-containing protein (Q57U66)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQFCGGLVCRTPPRRFAWKQTYSQLLPSHSMVPSAYICGRLRQAHHYSGRFACSAASVVVESPSDGAGILTFTANTVDGAARALSEIMHEAQALSHSVELRALERLEAILRQNADLLALAEALATGICLREARNSIGLAANVVGSCAERLRGCPASVAASETIDVEDLLRSLGCSDRGINCHGIRCATGGGSSVALCYTSANYPLQRGVEAIAAALLRGHVVVWLPSLEAPLSALWLMQLLCRSFSCQADENDSRSATSDDKGCDPGVGMHTVDPINIILYRGENSILLEKAFGVRGAREGLELVGLTNGFTEGQTNQFSVHLSDSQVRRSDISALYAIDWHHRLTKPAVAIVSVSQGESQSFSPSIPLTACAAVAKTDSAPTHVECVAENFFHHAFHCNGRTLHPLHVAFIPHEDVLPILRYLRERIRQVRIGHSLDSSVELGPLPTSKHLSLVKELIESATSGDDDAGVCIQQVCGGFEVAMPAGFFCLPCVLYARLPNEAPGAVSSMVERVMKLRTELDELGGGPVALVCAYDLRHQLDELHVWKDNAQHYVVHDW
Protein: Achaete-scute homolog 2 (ASH-2) (hASH2) (Class A basic helix-loop-helix protein 45) (bHLHa45) (Mash2) (Q99929)
Organism: Homo sapiens (Human)
Function: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11440538}.
Interaction partners:
- Pleckstrin homology-like domain family A member 2
- Potassium voltage-gated channel subfamily KQT member 1
- Solute carrier family 67 member A1
- Transcription factor E2-alpha
- U5 small nuclear ribonucleoprotein TSSC4
- Leucine-rich repeat-containing G-protein coupled receptor 5
- Cyclin-dependent kinase inhibitor 1C
- Olfactomedin-4
- Insulin-like growth factor 2
Sequence:
MDGGTLPRSAPPAPPVPVGCAARRRPASPELLRCSRRRRPATAETGGGAAAVARRNERERNRVKLVNLGFQALRQHVPHGGASKKLSKVETLRSAVEYIRALQRLLAEHDAVRNALAGGLRPQAVRPSAPRGPPGTTPVAASPSRASSSPGRGGSSEPGSPRSAYSSDDSGCEGALSPAERELLDFSSWLGGY
Protein: RBBP8 N-terminal-like protein (Q8NC74)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRGLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSPWEET
Protein: Potassium-transporting ATPase ATP-binding subunit (EC 7.2.2.6) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium-binding and translocating subunit B) (Potassium-translocating ATPase B chain) (P03960)
Organism: Escherichia coli (strain K12)
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2849541, ECO:0000269|PubMed:28636601, ECO:0000269|PubMed:30478378}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:28636601, ECO:0000269|PubMed:30478378}.
Interaction partners:
- Potassium-transporting ATPase potassium-binding subunit
- Potassium-transporting ATPase KdpC subunit
- Potassium-transporting ATPase KdpF subunit
- Sensor protein KdpD
- KDP operon transcriptional regulatory protein KdpE
- Iron
- Iron
- sn-glycerol-3-phosphate transport system permease protein UgpE
- Spermidine/putrescine import ATP-binding protein PotA
- Maltose/maltodextrin transport system permease protein MalG
Sequence:
MSRKQLALFEPTLVVQALKEAVKKLNPQAQWRNPVMFIVWIGSLLTTCISIAMASGAMPGNALFSAAISGWLWITVLFANFAEALAEGRSKAQANSLKGVKKTAFARKLREPKYGAAADKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQASEFIPAQGVDEKTLADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVEANGGHFPTDVDQKVDQVARQGATPLVVVEGSRVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNIMCLHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTASAMLRRNLWIYGLGGLLVPFIGIKVIDLLLTVCGLV
Protein: Heterochromatin protein 6 (IP05759p) (Q9VR09)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- LD09786p
- FI01426p
- Heterochromatin protein 1e
- Histone-lysine N-methyltransferase Su
- Heterochromatin protein 5, isoform B
Sequence:
MPSSTLTSSTALPVKQRNGFDLGLEPLRILGACNWSGKLTFLMQWKGCDEAGLVPAEVLNVRCPQMVISFYEERIVFTDEGDEEDLESDNGYETTPSPRKKRSRNA