Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (X2JF73)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- GH17761p
- Polyubiquitin
- Ubiquitin-like domain-containing protein
- Transcription-associated protein 1
- E3 ubiquitin-protein ligase UBR1
- Protein purity of essence
Sequence:
MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTVHVWIYGKCELYHWIEILDRFDKILEEASRHVNGNEFVLQCDTNFQETDVTLLLHVLNFTTLLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELLIVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDLCHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSILIYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPRAGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLASYEMGGTALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNGLNVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDTSLDHVDEDVEDGSGENASVTSGNASPRRDNSSDGATGAGSIVYRAYHEHIGGAGSGAGLLDIGGARSSLSGGSSGTSGMGAGSINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQRAALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVVTVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFEFLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADATEAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGHHVASTPSPMVMVAGTGSASSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQPTTPGQGGGPSTPRTQQAGGVVGSGAGATGTPAAASQAVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLPNLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRTILLKRWGVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTADPLTEAELSRKLERAAEFRTKYTPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVGSPQTRQRRINDLISNITKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLICSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFEFDQWASMEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYMPDSVPFEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHTRMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNPEASSLSTTGGQSSSSAPPPPPPPSASTMDIDVDVPADGESTQSKSSTSPNSSYDYKHLKLMPSLIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQWVDFTLQLFEPAKTTGSKASRLEECLTGMTATRLFVRLKTSTLLLEENYSDLHRPLVEAITAQDAMVSLVKLLDCMSQWMLEQSTETNTGQQRATVPRWVQNLVDLIDAIDSISHILQRKANMRAVSSDVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLYINIGRQRCTVSLNCMTQVSEASGTHRPVCPALKLSEAITSLNNPVALHKVEHILNRVVRTAPDGSGTVHSDELISLRQLVNFTDGQQPQQSENSANPSEEATSEDGPAAANSGSPPATMTTRSKTRQKSAAAAAAAKNKSQSGGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHQMLNETKLSLLRLCARLTRNYDNAQVFIRRGGVRMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLINTNSTTLADDARVMVKSKFGQQPTAAAGGATPHNQTPTPPPAAKDELKDDPQVQSSVAVLKELLHGLVQPCWHYGGTGSLDRGQGAAELLQPDQPPGTAQGCHDDELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQATEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLLSHVYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYRVLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGSGGPGGPNASGNGNNTAGGSSGNGPGSGNTYGTIINRRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDRRHAFEFIFNSDDMAVDSEDAAAPGSGVGGGGSGAGSVGGGVSGSVSGNSSAAVIDVVEERSNGGDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQSEGLRLASRSGGGAGSGSGSVGASSSGQQNGSNTTASSTNSGNNSGIGNLRLRTNPDVDVGSGNGSGSGSGSNAGVVNDNGISGGGGSDGASTSSDTGAPGGARDLNASLLGDVSTSESDSDPSTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERSRQFIEVFDHIYEPESSETASNDADVDNDDDDDEDDVDDDDDDDEDNDDDVREEVQSVMDAEIENRIDIALALVSSNNRPRRSAAVNASGDGSANRTNPDDEVDDEDDDVDADPDGDPDVDPISGPSAAQAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTGGTTASIGAIASAALRPSSGSWMAPDFNFIRISGGDSSMGSGPAIGGNANGGDMNVFITPSMSLERAGGAPGSGQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQHPNATLCTNGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDMESQTDACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA