wanglab/gogpt-training-data huggingface dataset:
Protein: Gim5A protein (Q38DN1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Interaction partners:
Sequence:
MSAQAHTYLCDAWNRDKVMAIVQFLPMALEGPARTAGCESLALSLGNLARMGDAYRAVTRLSLLANALSKPTLTSLSKPTGDMVASRIDQLSHLFHIGFCLNENTAVLAGHGVFPKSLHRLSGVAVLCWMYTLALGIVRQLYLFVKLRPRQASRGAGAGDDKKVPAYTYLELKRAFVNLLKLVCYFLFALTCLPEGKPQLLANARGPLVPLHVMVKALSPNPLHASNTVRGLLGLIASVCEFY
Protein: Mitochondrial metalloendopeptidase OMA1 (EC 3.4.24.-) (Q9P7G4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Protease that is part of the quality control system in the inner membrane of mitochondria. Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane protein.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P36163}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- ATP-dependent zinc metalloprotease YME1 homolog
- Dynamin-like GTPase msp1, mitochondrial
Sequence:
MFLNKYISNYSRTRAVSCAPVLSYKKCSYRNFNGLLQARFQSNNLSWSNRNRVVYKSFQPNPRDKRFQWIFGALIAGGGVYYFTHLEYVPISNRRRFNDVSLDFEKRMAQDAYKEVMSEYGDRMLPSYHPTTLYVSRVLKRIIAVSGMSDLKWELHVIRDPTPNAFVLPGGKVFVFEGILPMCKGEDGLAAVLAHETAHQVARHSAEKIAFTRAVSCIVFLAAASLDLSGQLSHFLLNFGLLLPFSRKMETEADYIGLMLMSQACFDPNAAKTLWERMDAAEGQMGKALAFASTHPSSKKRIRKIEEWLPEAQVKRETSDCYHETWPMLQSFKEVHW
Protein: ATP synthase subunit 9, mitochondrial (Lipid-binding protein) (P0C518)
Organism: Oryza sativa subsp. indica (Rice)
Function: This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLEGAKLIGAGAATIALAGAAVGIGNVFSSLIHSVARNPSLAKQLFGYAILGFALTEAIALFALMMAFLILFVF
Protein: Glucagon receptor b (Glucagon receptor isoform X1) (F1RCQ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Glucagon b
- Glucagon receptor a
- Guanine nucleotide-binding protein G
- Insulin
- Glucagon a
- Insulin
- Gnb2 protein, beta polypeptide 2)/G
- Guanine nucleotide binding protein
- Gnb1l protein, beta polypeptide 1, like), beta polypeptide 1b isoform X1), beta polypeptide 1b)
Sequence:
MSVCLLLVLFILTTHTQVSSGKSLKLLQEQWRIYTNECIQSFISTPPAAGLVCNRTFDQYVCWPDGLPGTTVNVSCPWYLPWYSKVDHGLVYRVCGADGRWVHGKNTSECEQDDPGQKQYGQILSKFRAMYTVGYSLSLAALTLALGILVSFRKLHCMRNNIHMNLFGSFMVRALSILIKDTLLDQMNRARSGPSHYQSTRWLDTQTVVGCRSAMVMMQYSVMANNCWLLVEGLYLHSLLVTTVFSERNYFCIYLCIGWGAPLIFVLPWMTVKYLYENEECWERNMNMGYWWIIRSPILFAYLINFIIFIRIIKILMSKLKAHQMRYTDYKFRLAKSTLTLIPLLGIHAVLFTFVIDESVPKESLLRLIRLFYDLLFSSFQGLLVAILYCFVNKEVQSEMLKKWKRWKLGKDIDEEYRHTHSQTPHAKSSTAPPAAHDCPDTSSSLESQRLVTGLQNGLSRSRGRARLQFTSQTQEGASNCSSLTEDICLEERPLNNEGSAAVLEETNV
Protein: Muscleblind-like protein 2 isoform A (Muscleblind-like-splicing regulator 2) (F1Q5U6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MALNIASIRDTKWLTLEVCREFQRGNCARGETDCRFAHPSDSPMIDTSDNTVTVCMDYIKSRCSREKCKYFHPPAHLQAKIKAAQHQANQTAVAAQAAAAAMTQSTAKAMKRPLEASVDLAFPHGVLQPLPKRPALEKSNGASTLFNPSVLHYQQALASAQLQQPTAAFFPTVPMMYSATPATVSAATTPATSVPYATTAPANQIILK
Protein: Aklanonic acid methyl ester cyclase DauD (AAME cyclase) (EC 5.5.1.23) (Methyl aklanonate cyclase) (Q55215)
Organism: Streptomyces sp. (strain C5)
Function: Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone.
Interaction partners:
Sequence:
MSPQIDLVRRMVEAYNTGKTDDVAEFILHEYLNPGALEHNPELRGPEAFAAAVTWLKYAFSEEAHLEEIGYEENGPWVRAKLALYGRHVGNLVGMPATGRRFSGEQIHLIRIVDGKIRDHRDWPDYLGTYRQLGEPWPTPEGWRPCPPPPRRRHDRSTDTP
Protein: H-2 class I histocompatibility antigen, K-Q alpha chain (H-2K(Q)) (P14428)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
PRFISVGYVDDTELVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Protein: 5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F) (P30939)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21422162, ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}; Multi-pass membrane protein {ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein subunit beta-5
- Endothelin-3
- Somatostatin
Sequence:
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
Protein: Uncharacterized protein (Q57VZ9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTFVDLFDMTVAYVQYLYIMVSLSPNSFPEIILQPLSKGQLALLHISYDYLTGDSQKREQMFTLPNWIPHDSRLNYTFIVVIIPMVISLGGFLIVSSTGASLCLFAQVVAVFFTVLGAVLVSTPRAEKMEIMTRETQRILVLAGGVGLIVLFVAGIIYLFMLRRSQKKKRRLEMAADRGAEHREEVSAIQKAVRRVTQNKRATSALLAYEAKKEVYVQARRWRSILIQLLVCGIAIAAGYFIYVTLPTEDSAEALKIGRYDKAVAITFFVASSVIVIWALLSISQKGRQIQVKLTDKLSKALTSTALIALSIAFTPVTLNMMRLLVCTEVSCNEGEMMIRMKSAVGGSRNFSNSWDTTEKPCLACNFTEHTQKCSKSLQIKLCGGNIREKRLAYDPRVSCREIDNFYKMSMSLVFIAYFVAYPAFLILSIDRATSILVDEYPLEKRICDEFNKKELYYEKTLMSRNVSSSLYVAFKYQFRRSRILFLLQRILLVLIGVLMRRGPGSVVAWLGISLITCICLVYLTYLMMVRPYARPVENWYSISHQLVLTFIGSLGVVGSMSTRELVPNAVTITAVALMIVAPMFALIVGSVLTFRNDRQRVERLQSRLKRDFETVADTAENQSPDNVVVGESLDNPNCKGQATACTDPDLPPRGDGTTVGSAQSPGDMANNPQPGAEVNDSSNGRETGLPAQNPQVLASLPAAGGGVKGDNTRQRSGNRADREGAPASGPSDGADIGTAVVFADEHNAPEETDKKEKVMKDDYFGDKRSFEPQEYFRGYKEVPLSHDCGEGEGEGEGGGMDDELYEQTAVKRGELKAVLSSLIREGDDYLPDDGYPPGVAVPSNALDGWRHETQHGEEYDSAKKEDDATKGKPSCFSVMLRWMRQCGKAFHVHSNTLRYGEVLQSRRTLKMTAGIAERPFWITPSESQFLAAKAEGCDVPAIRQSAGGDEGPSSPYEPSQFFAKLVEHKKKCWNPLVGPSSRAVTAAKTAKEGSGKTKGSNSPSSALAVVASNLPVAKEGNVNPYGQTITSDVSDRISAMLSKEQLCAALAELKAADLDRLLPRDLKDTTVTERRPSICPEFAPHVALEGESEGNWEAFVQRLLEDIPDPLEKYRETGSRESAEAEGSPKDTTTGRRQSVTLDAALKMAGSPSAKRKSWMDVSSARALVRGAANMNAENMPKLRRHYLLRQQLVDEYNSEAGKLESLQMAVDHRIAMSIRRYMQIFFVALCLFSTLSLAMCIGGMMYKGDNISLTNAQSAYSVHNQLFGYKSWEEFTRNCCCSSLSSPAALPPNNVMALERWVCRNRLVKERVRRDVLKGEAVDGFKIRELCGMDFKNGCKLKLHPKGRVEIENCTTPVTEQEILRW
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q5XEP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA ligase 6
Sequence:
MDGCAGKRSVDRLVVPRKASGLTLRENMNKTDGKNVPFCSRVGCTAKVTSTKRSRIGSTDNNTKVGLPPVPSTLNRKEIVGSSSRTPGGFGYLRKPAKVTARRQPSSSLDTESSETSCIHDDPAATEPTLPRQKTKRVTINVHPQSAVSREVVITKAGSSSRGTSRISHPKSELGTRDALTGPSVSTSSGNSEHTVRGGLSRHRLRNLSCNSVSDVLPTNSNSATKISVTKKKNADGESSLSSKGSKTSVLVPKVRNQISSHGNGVTVSDNRRNRVVPSIRDSSTVVSNGCRRAGYFGRSERLGATASSATSRQMPHPTTPTDPNPSLSFCPSNIYSSTGRVHSNMPGSPTEADPSSSLVNRDGLSHYNMNGIAEVLLALERIEHDEELTYEQLASIETNLFSSGMFRFYDQHRDMRLDIDNMSYEELLALGDKMGTVSTALSEEALSRSLKQSIYQETDETGSISLYKDDDIKCSICQEEYVDGDELGTIPCQHMYHVSCVQQWLRMKNWCPICKTSAEEEKSI
Protein: Ataxin-1 (Spinocerebellar ataxia type 1 protein) (P54253)
Organism: Homo sapiens (Human)
Function: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7647801}. Nucleus {ECO:0000269|PubMed:12093161, ECO:0000269|PubMed:7647801}. Note=Colocalizes with USP7 in the nucleus. {ECO:0000269|PubMed:12093161}.
Interaction partners:
- Protein capicua homolog
- Ubiquilin-4
- Histone acetyltransferase KAT5
- Nuclear receptor corepressor 2
- Splicing factor 45
- Ataxin-1-like
- Ataxin-2
- Recombining binding protein suppressor of hairless
- Polyglutamine-binding protein 1
- Pumilio homolog 2
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Protein: Ribosome recycling factor domain-containing protein (Q585M5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFSCVYGLRGSQRHIDHTTDTSTSLSIVWSIWIGAGTYLLHFSHKSSNLFPLCLFNIPSLCGDSSAVSMRRMLLAAAGSIRWWNIARHHQQLTALRLVGSFPFNSTIQRLKDVRRGDRGESRRLTFEERSERRSGKSREQKAEKENLLQEAETVVSEDVPEELEQVFQHHFERANVSAMKVLNMAKCLEQLDVDVGGGRKVLLTKVAQVLKTGAATMEVVPQNVSFASPILQRVTRFDGTLQVSKEQQKIKITMPPITTARRQKAVEEIQLVVSSFKNKVKQVRTQASRALQESGIDETASRELHQQLDECVHSFVEDKVTELEQLSSDVTSMGADESDVVA
Protein: CASP8-associated protein 2 (FLICE-associated huge protein) (Q9WUF3)
Organism: Mus musculus (Mouse)
Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17003125}. Nucleus, PML body {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Exported from the nucleus to the mitochondria upon FAS activation. {ECO:0000250}.
Interaction partners:
- Caspase-8
- U7 snRNA-associated Sm-like protein LSm11
Sequence:
MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSAVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYNDLQIEYGKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSQSTSPHLDDCSKTDHGVKSDVQKDVHPNTAQPNLEKEGKSHSEAQNPLHLSTGVEKHCANNVWSRSPYQVGEGNSNEDNRRGRSGTRHSQCSRGTDRTQKDLHSSCNDSEPRDKEANSRLQGHPEKHGNSEARTESKISESKSSTGMGYKSERSASSWEKETSRERPHTRVESQHDKNLEKQNERLQNMHRKELPSQDKTERKVDVKFKPAGEEQGHRGRVDRALPPHPKNDVKHYGFNKYHPEERRGREDCKRDRGMNSHGFQDRRCSSFLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTADGKRQTEPKHGKGAVSNSELSKGTDSKEGATKVESGPNEAKGKDLKLSFMEKLNLTLSPAKKQPACQDNPHQITGVPEPSGTCDSRSLETTGTVACLPSGSEHNREETKSELPEPKEALLATSQLRISIPENKMKEEKRLLFKSVENTVPCELLACGTEISLPAPVEIEQARCLLGSVEVEETCGGARTAASVVMHVLPEHASEDASQELDTKRHDGINACAISEGVKTKVILSPKAAAASESHLAPLVEEPSISLVNCSGDNNPKLEPSLEERPIVETKSCPLESCLPKETFVPSPQKTELIDHKIETGESNSVYQDDDNSVLSIDFNNLRPIPDPISPLNSPVRPVCKVVSMESSCAIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKFDKCSEADSCKHLSLDELEEGEIRSDDEESVAQKRLEKSARPRVSAEVQPGKSSPGSRRSTVHVHKDNGRTAVKLPRDRLTWSKRSSESRPSNTERKSKTMSISSLEKILPLILVPSSLWEVMHMLRLLGKHVRKNYMKFKIKFSLTQFHRIIESAILSFTSLVKCLDLSKICKSVSTLQKSLCEVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVNFENENSEGKLGKKYKERTQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKSEEKHQDQNKTNASIVKHDVKRTFSTCSDNTKNAECKEQFLEKSCPSTPRPGKDEGHTEEEAQAAQHASAKSERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTSGTEKAEWELKTPEKQLLESLKCESAPACATEELVSEGASLCPKVISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNTALGKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGVVAEESLTSLPRTGKEAGVATEKEPNLFQSTVLKPVKDLENTDKNIDKSKLTHEEQNSIVQTQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSENLQELPSMEKIPHSLDNHLPDTHIDLTKDSATETKSLGELMEVTVLNVDHLECSQTNLDQDAEITCSSLQPDTIDAFIDLTHDASSESKNEGSEPVLAVEGMGCQVICIDEDTNKEGKMGRANSPLESIVEETCIDLTSESPGSCEIKRHNLKSEPPSKLDCLELPETLGNGHKKRKNSPGVSHSSQKKQRKDIDLSSEKTQRLSPNSDRNGDAHRKQASKKREPAVNETSLSSEASPEVKGSTAVLAASPASLSAKNVIKKKGEIIVSWTRNDDREILLECQKRMPSLKTFTYLAVKLNKNPNQVSERFQQLKKLFEKSKCR
Protein: Cytidine deaminase 1 (At-CDA1) (EC 3.5.4.5) (O65896)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Functions as a conventional cytidine deaminase. Has no affinity for RNA and is not involved in RNA-editing by C-to-U deamination.
Interaction partners:
- Thymidine kinase a
- Thymidine kinase b
- Uridine nucleosidase 1
- N6-mAMP deaminase
- tRNA
- At1g72880
- 5'-nucleotidase
- NF-X1-type zinc finger protein NFXL2
- AT4g39900/T5J17_70
- Probable inactive uracil-DNA glycosylase
Sequence:
MDKPSFVIQSKEAESAAKQLGVSVIQLLPSLVKPAQSYARTPISKFNVAVVGLGSSGRIFLGVNVEFPNLPLHHSIHAEQFLVTNLTLNGERHLNFFAVSAAPCGHCRQFLQEIRDAPEIKILITDPNNSADSDSAADSDGFLRLGSFLPHRFGPDDLLGKDHPLLLESHDNHLKISDLDSICNGNTDSSADLKQTALAAANRSYAPYSLCPSGVSLVDCDGKVYRGWYMESAAYNPSMGPVQAALVDYVANGGGGGYERIVGAVLVEKEDAVVRQEHTARLLLETISPKCEFKVFHCYEA
Protein: Probable beta-carotene 15,15'-dioxygenase Blh (EC 1.13.11.63) (Brp-like homolog) (Q9HNE6)
Organism: Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Function: Appears to partially substitute for Brp function in retinal biosynthesis during bacteriorhodopsin production. Probably catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02093, ECO:0000305}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02093, ECO:0000305}.
Interaction partners:
- Lycopene beta-cyclase
- Phytoene synthase
- Bifunctional short chain isoprenyl diphosphatesynthase
- Bacterio-opsin linked product
- Bacteriorhodopsin
Sequence:
MGASPVALTPLTARARRTLARPALALGWVAISIAALPAITGVSLSPTARYAPLVASAVVFGMPHGAIDYLALPRAVTGTVTVRWLAVVGVLYLVLGGGYAAAWFFAPVPAAFAFVAITWLHWGQGDLYPLLDFLDVDYLDTRPRRAATVLIRGGLPMLVPLLGFPERYRSVVDAFAAPFGGSVGDLAVFDPRVRLWLGVAFAAATVAVLAAGRRRTHSPGAWRVDAAETLLLWVFFFVVPPVFAVGVYFCVWHSVRHVARAIAVDGSVHPSLRAGDILGPLARFGVEAAPMTAAALALGGVLWWAVPNPPTTLESGAALYLVLIAVLTLPHVAVVTWMDRVQGVL
Protein: EH domain-binding protein 1-like protein 1 (Q8N3D4)
Organism: Homo sapiens (Human)
Function: May act as Rab effector protein and play a role in vesicle trafficking.
Subcellular location: Endosome {ECO:0000305|PubMed:27552051}.
Interaction partners:
- Ras-related protein Rab-8A
Sequence:
MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYEAKEWTFIIENESKGQRKVLATAEVDLARHAGPVPVQVPVRLRLKPKSVKVVQAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEDEAHGPGAPEARARVPQPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPAPVSAPAPPARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALEKEAARSRVLESEVAGTAQCEGLETQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEISGDLGPLKIEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAAEGAILGTQEIASRDSGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGSGISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVGSALKYEALRAPVTQPRVLGSQEAKAEISGVQGSETQVLRVQEAEAGVWGMSEGKSGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGKEAEGSLTEASLPEAQVASGAGAGAPRASSPEKAEEDRRLPGSQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGPQEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDADLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQALEQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQQHREQLLLEELVSLVNQRDELVRDLDHKERIALEEDERLERGLEQRRRKLSRQLSRRERCVLS
Protein: Type 2A phosphatase activator tip41 (PP2A phosphatase activator tip41) (Q9USK5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Activates the PP2A phosphatase ppa2.
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C63.05
- Serine/threonine-protein phosphatase 2A activator 1
- Leucine carboxyl methyltransferase 1
Sequence:
MQKQDDFSFKYWTIKVQRGSILKSHEMENLQSTLGFPPPEMTFGNNYISIEYKNQPVVGFFTEDALKMVGTKPEDVMQVSFAKDWAKSRIKPGEEYPVIYPFDWTYYTDYQGTIQRPNAKFIEIDQVIPVQKILNAGQNLWFNEIILFEDELADNGKSMFDVRARVVQGHLILLARLVVRLDKVNVRLNETRIYIDLLNDFLLKDCRKKQATYDKIIKQIPVGGDKAALLDDNNWLSERLDTVDHKIYKLNF
Protein: Prothymosin alpha-B (A5PLC8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P06454}.
Interaction partners:
Sequence:
MADAKVDSATEISAKDLKEKKLIEEKENGKDATNGKENEENGEPEIDDEDDDEVDEDDEEGEGDEDEDEDDDDEDLGGGTKRGADDDEDEDEDDEDDVDPKKQKVN
Protein: Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) (Receptor of activated protein kinase C 1) (RACK1) (P63247)
Organism: Gallus gallus (Chicken)
Function: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P63244}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63244}. Cytoplasm {ECO:0000250|UniProtKB:P63244}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P63244}. Nucleus {ECO:0000250|UniProtKB:P63244}. Perikaryon {ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite {ECO:0000250|UniProtKB:P68040}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery (By similarity). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). {ECO:0000250|UniProtKB:P63244, ECO:0000250|UniProtKB:P68040}.
Interaction partners:
- Ribosomal protein L19
- 60S ribosomal protein L32
- Small ribosomal subunit protein eS4
- TRASH domain-containing protein.
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL36
- Ubiquitin-ribosomal protein eS31 fusion protein
- 60S ribosomal protein L18a
- 40S ribosomal protein S30
- Large ribosomal subunit protein uL2
Sequence:
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR
Protein: Vacuolar ATP synthase subunit D, putative (Q38BM3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- H
- ATP synthase, putative
- V-type proton ATPase subunit
- V-type ATPase, C subunit, putative
- 
- V-type proton ATPase subunit F
- V-type proton ATPase subunit a
- V-type proton ATPase subunit C
- Vacuolar proton pump subunit B
Sequence:
MSSNRYTALPSRMSLIAFKTRLKGAQKGHSLLKKKADALAFRYRTVMDELRRAKLEVADQIKGSYFTITQAQFIAGDISLAVQESLKLPTYTLTLRVDNVAGVRVPAFTERNSRDESTAAGGNQQNNKSRSGVNSYGNYGSGGGPSKQQATSAAGIGRGGEQLREARDAFRETLKLFVKIASLQVSWMTLDVAQKVTSRRVNALEKVVIPRMENTLNYISSELDEQEREEFFRLKMIQKKKKILQQNKDRKEAADNAAAAASNLLSMSPGKDDNDVTEADLVV
Protein: At4g33625 (Vacuole protein) (Q8GXK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Vacuolar sorting protein 18
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar protein-sorting-associated protein 33 homolog
- Transducin family protein / WD-40 repeat family protein
- Transducin family protein / WD-40 repeat family protein
- Alpha/beta-Hydrolases superfamily protein
Sequence:
MDRTEEIEESPAGPSSGSAKLKLGNRADPFLVVCRCFSLVTSLIAILCVVVNVLAAVRSFRDSHDLFDGIFRCYAVVIACFVVLVETEWGFILKFSKVLEYWAGRGMLQIFVAVMTRAFPDYMTQKKDLLLLQNIASYLLLACGVIYVISGVLCIGFLKRARQQKEVSREQAVKDLEEIARRKEELEQLLLEHQSRDEDV
Protein: Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (Q5ANP2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. {ECO:0000250}.
Interaction partners:
- Nascent polypeptide-associated complex subunit beta
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein eL21
Sequence:
MSIEEIPQGADVNVIPKNEKKARELIKKLNLKQIKGISRVTFKQRGNLIYAIDSPDVYRSAAGTYVVFGEAKVDDMNQRIAEAQAQQAQQEALQKAAADAGKTEDKSPEAITADLEKASLGDKKAEDEEEDEGEIDETGLDPKDIEIVVEQTQVSRAKAVKALRNHDGDMVNAIMDLS