wanglab/gogpt-training-data huggingface dataset:
Protein: BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) (O95817)
Organism: Homo sapiens (Human)
Function: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
Subcellular location: Nucleus {ECO:0000269|PubMed:26159920}. Cytoplasm {ECO:0000269|PubMed:26159920}. Note=Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). {ECO:0000269|PubMed:26159920}.
Interaction partners:
- Heat shock protein beta-8
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 4
- E3 ubiquitin-protein ligase CHIP
- Apoptosis regulator Bcl-2
- Heat shock 70 kDa protein 1A
- Heat shock protein beta-1
- BAG family molecular chaperone regulator 2
- BAG family molecular chaperone regulator 1
- Heat shock protein HSP 90-beta
Sequence:
MSAATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRKEVDSKPVSQKPPPPSEKVEVKVPPAPVPCPPPSPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQPEATAAATSNPSSMTDTPGNPAAP
Protein: Proteasome subunit beta type-4 (Proteasome subunit beta type-7) (Q9VNA5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3
- Proteasome subunit beta
- Proteasome subunit alpha type-7-1
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-2
- Proteasome subunit beta
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
Sequence:
MLNNYNSLAQPMWQNGPAPGEFYNFTGGQTPVQQLPRELTTMGPYGTKHSTASSTTGTSVLGIRYDSGVMLAADTLVSYGSMARYQNIERVFKVNKNILLGGSGDFADIQSIKRNIDQKMIEDQCCDDNIEMKPKSLASWMTRVLYNRRSRMNPLYIDVVVGGVDNEGTPYLANVDLRGRSYEDYVVATGFARHLAVPLVREKKPKDRDFTAVEASELIRTCMEVLYYRDTRNISQYTVGVCSVNGCGVEGPFQVNENWTFAETIKGY
Protein: C-type lectin domain containing 5A (C9JPR7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGKYVNMPQFPGDLGLLQKTKPEIAGFTLE
Protein: Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] (Q9NZV1)
Organism: Homo sapiens (Human)
Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
Subcellular location: [Processed cysteine-rich motor neuron 1 protein]: Secreted.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12805376}; Single-pass type I membrane protein {ECO:0000269|PubMed:12805376}.
Interaction partners:
- Fasciculation and elongation protein zeta-2
- Ubiquitin-like protein FUBI
- Vacuolar protein sorting-associated protein 41 homolog
Sequence:
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV
Protein: Keratin-associated protein 10-11 (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11) (P60412)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 10-7
- Keratin-associated protein 10-12
- Keratin-associated protein 10-9
- Keratin-associated protein 10-8
- Keratin-associated protein 10-10
- Keratin-associated protein 10-4
- Keratin-associated protein 19-3
Sequence:
MAASTMSVCSSAYSDSWQVDDCPESCCEPPCSAPSCCAPAPSLSLVCTPVSCVSSPCCQAACEPSACQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKTVCCKPVCCVPVCCGAASSCCRQSSCQPACCASSSCQPACCVPVCCKPVCCVSTCSEDSSSCCQQSSCQPACCTSSSYQQACCVPVCCKTVYCKPICCVPVCSRASSSRCQQPSCQPACCTTSCCRPSSSVSLLCHPVCRSTCCVPVSSCCAPTSSCQSSCCRPASCVSLLCRPASSRLACYSLCSGKKSSC
Protein: Protein SNQ2 (P32568)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Could be an ATP-dependent permease. Confers hyper-resistance to the mutagens 4-nitroquinoline-N-oxide (4-NQO) and triaziquone, as well as to the chemicals sulphomethuron methyl phenanthroline when present in multiple copies. Exhibits nucleoside triphosphatase activity.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Oligomycin resistance ATP-dependent permease YOR1
- Transcription factor PDR3
- Transcription factor PDR1
- Pleiotropic ABC efflux transporter of multiple drugs
- Zinc finger transcription factor YRR1
- Hexose transporter HXT9
- Hexose transporter HXT14
- Metal resistance protein YCF1
- Hexose transporter HXT11
- Fluconazole resistance protein 1
Sequence:
MSNIKSTQDSSHNAVARSSSASFAASEESFTGITHDKDEQSDTPADKLTKMLTGPARDTASQISATVSEMAPDVVSKVESFADALSRHTTRSGAFNMDSDSDDGFDAHAIFESFVRDADEQGIHIRKAGVTIEDVSAKGVDASALEGATFGNILCLPLTIFKGIKAKRHQKMRQIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGEVAYDGIPQEEMMKRYKADVIYNGELDVHFPYLTVKQTLDFAIACKTPALRVNNVSKKEYIASRRDLYATIFGLRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTALEYAKAIRIMTNLLKSTAFVTIYQASENIYETFDKVTVLYSGKQIYFGLIHEAKPYFAKMGYLCPPRQATAEFLTALTDPNGFHLIKPGYENKVPRTAEEFETYWLNSPEFAQMKKDIAAYKEKVNTEKTKEVYDESMAQEKSKYTRKKSYYTVSYWEQVKLCTQRGFQRIYGNKSYTVINVCSAIIQSFITGSLFYNTPSSTSGAFSRGGVLYFALLYYSLMGLANISFEHRPILQKHKGYSLYHPSAEAIGSTLASFPFRMIGLTCFFIILFFLSGLHRTAGSFFTIYLFLTMCSEAINGLFEMVSSVCDTLSQANSISGILMMSISMYSTYMIQLPSMHPWFKWISYVLPIRYAFESMLNAEFHGRHMDCANTLVPSGGDYDNLSDDYKVCAFVGSKPGQSYVLGDDYLKNQFQYVYKHTWRNFGILWCFLLGYVVLKVIFTEYKRPVKGGGDALIFKKGSKRFIAHADEESPDNVNDIDAKEQFSSESSGANDEVFDDLEAKGVFIWKDVCFTIPYEGGKRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQRNVGIITGDMLVNGRPIDASFERRTGYVQQQDIHIAELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAEALVGEVGCGLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILEAIGAGATASVKEDWHEKWLNSVEFEQTKEKVQDLINDLSKQETKSEVGDKPSKYATSYAYQFRYVLIRTSTSFWRSLNYIMSKMMLMLVGGLYIGFTFFNVGKSYVGLQNAMFAAFISIILSAPAMNQIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSELPYHLFFSTIFFVSSYFPLRIFFEASRSAVYFLNYCIMFQLYYVGLGLMILYMSPNLPSANVILGLCLSFMLSFCGVTQPVSLMPGFWTFMWKASPYTYFVQNLVGIMLHKKPVVCKKKELNYFNPPNGSTCGEYMKPFLEKATGYIENPDATSDCAYCIYEVGDNYLTHISSKYSYLWRNFGIFWIYIFFNIIAMVCVYYLFHVRQSSFLSPVSILNKIKNIRKKKQ
Protein: Helicase-like transcription factor CHR28 (EC 3.6.4.-) (Protein CHROMATIN REMODELING 28) (Protein SNF2-RING-HELICASE-LIKE 2) (Q94BR5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin. Associates with SUVR2 and functions redundantly with FRG1. Required for the efficient methylation of a broad range of RdDM target loci.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9ZUL5}.
Interaction partners:
- Probable inactive histone-lysine N-methyltransferase SUVR2
- Chromatin structure-remodeling complex protein SYD
- RuvB-like protein 1
- Protein INVOLVED IN DE NOVO 2
- Probable inactive DNA
- DNA-directed RNA polymerase V subunit 1
- DEAD-box ATP-dependent RNA helicase 26
- Protein DEFECTIVE IN MERISTEM SILENCING 3
- DExH-box ATP-dependent RNA helicase DExH18, mitochondrial
- Actin-related protein 5
Sequence:
MDSAIDISSDSDVEIQETRTRPQHPPRIAEGSHRRDLSTLRPHFLSGSSSGANGHTKTGLTNLDSRNGFESKPLPRAEHHTHIPGNGSIVTSRIPNISVGDYEKFSSQQAFKRTHPPTFSRPPFPPRPDIGTSNGNASHFRGGAHDDLGMGRVTNGTRILPPSVAHGTSASPSHFNGLSDPMHRNGIGEERNSENDERLIYQAALQELNQPKSEVDLPAGLLSVPLMKHQKIALAWMFQKETNSLHCMGGILADDQGLGKTVSTIALILKQMHEAKLKSKNSGNQEAEALDLDADDESENAFEKPESKASNGSGVNGDSGIKKAKGEEASTSTRKFNRKRPAAGTLIVCPASVVRQWARELDEKVTDEAKLSVLIYHGGNRTKDPIELAKYDVVMTTYAIVSNEVPKQPLVDDDENDEKNSEKYGLASGFSINKKRKNVVGTTKKSKKKKGNNNAGDSSDPDSGTLAKVGWFRVVLDEAQTIKNHRTQVARACCGLRAKRRWCLSGTPIQNTIDDLYSYFRFLKYDPYAVYKSFCHQIKGPISRNSLQGYKKLQAVLRAIMLRRTKGTLLDGQPIINLPPKTINLSQVDFSVEERSFYVKLESDSRSQFKAYAAAGTLNQNYANILLMLLRLRQACDHPQLVKRYNSDSVGKVSEEAVKKLPKEDLVSLLSRLESSPICCVCHDPPEDPVVTLCGHIFCYQCVSDYITGDEDTCPAPRCREQLAHDVVFSKSTLRSCVADDLGCSSSEDNSHDKSVFQNGEFSSSKIKAVLDILQSLSNQGTSNSTQNGQMASSSQQPNDDDDDDDDDVTIVEKTSLKSTPSNGGPIKTIIFSQWTGMLDLVELSLIENSIEFRRLDGTMSLIARDRAVKEFSNDPDVKVMIMSLKAGNLGLNMIAACHVILLDLWWNPTTEDQAIDRAHRIGQTRPVTVTRITIKNTVEDRILALQEEKRKMVASAFGEDHGGSSATRLTVDDLKYLFMV
Protein: Protein disulfide-isomerase (EC 5.3.4.1) (I3L4M2)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}. Melanosome {ECO:0000256|ARBA:ARBA00004223}.
Interaction partners:
Sequence:
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVRLPSRRGWGGLWEEQWSPRQPGCLSGRSLGLVRSLITTGNARWMVLRNSWRAVARMGQGMMTISRTWKKQRSQTWRKTMIRKL
Protein: Homeobox protein unc-4 (Homeobox protein ceh-4) (Uncoordinated protein 4) (P29506)
Organism: Caenorhabditis elegans
Function: Transcription factor. Involved in motor neuron fate determination and maintenance. In concert with unc-37, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate. Regulates synaptic specificity and the pattern of synaptic input to VA motor neurons, and, depending on context, acting in opposition to, or supported by, Wnt signaling. Required in patterning of the synaptic outputs of the postmitotic DA class cholinergic motor neurons. Acts as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons, probably by binding to specific promoter elements. Has no role in axonal guidance or outgrowth.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor unc-37
- Cuticle collagen dpy-10
- Protein unc-119
- Transcription factor unc-3
- T-box protein 12
Sequence:
MIGALHACVDAEPKIINDIWADFWKSQINSVLLNPSDGSETYLASDNGKSTSSREQSTSPDDDNLLMNEDDGIALEDDNDTGESAAKRRRTRTNFSGWQLEELESAFEASHYPDVFMREALAMRLDLLESRVQVWFQNRRAKWRKREQNRNGSSEIKKDDGEQMETKALPTFPFSIDSILAVSRVPRGRRPNAKYPRVQACKNLSPFMIPLFPITQPGGNVIREKSPPLPTQQSQIVATNALTTVAELLKSV
Protein: 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) (Q07343)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Subcellular location: [Isoform PDE4B5]: Cytoplasm {ECO:0000269|PubMed:17519386}. Cell membrane {ECO:0000269|PubMed:17519386}.
Interaction partners:
- Disrupted in schizophrenia 1 protein
- Alpha-aminoadipic semialdehyde dehydrogenase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- GTP:AMP phosphotransferase AK3, mitochondrial
- Deoxycytidine kinase
- Adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Adenylate cyclase type 8
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
Protein: Natriuretic peptide B (Natriuretic peptides B precursor) (F1R8L8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003686}.
Interaction partners:
- Natriuretic peptide A
- Natriuretic peptide receptor 3.
- Guanylate cyclase
- Insulin-degrading enzyme
- Corin, serine peptidase.
- Myosin heavy chain 7
Sequence:
MKSLHIPVVGLLFLLSVQHMRTFPLQSTALTNDDMGVLKFLLQRLEESIPAQDQTPAEREVKAANIEETRAEEQPDTYLREYLSARDLKTVRKDSKKKNSGCFGSKLDRIGSMSSLGCNTVGRSGPKKN
Protein: SKI3 subunit of superkiller complex (D6RCE2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSKEVKTALKSARDAIRNKEYKEALKHCKGLANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQFLAESTEDQNNETQQLLFTAFENALGLSDKIPSEDHQVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYPLEVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGLKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKIVDNLGASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMII
Protein: KLLA0E03807p (Q6CPM4)
Organism: Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Interaction partners:
- KLLA0F13816p
- KLLA0D09977p
- E3 ubiquitin ligase complex SCF subunit
Sequence:
MSKLDSLLKELPTRTAHLYRSIWHKYTEWLKTMPDLTGADLKLFLSQKYIVKYIASHDDIAKDPLPTCDAMIWFSRALDIENNDVLVLQQRLYGLVKLLEFDYSNVIAILQKISINLWNPSTDSLQSKHFKTCQDKLKLLLDFQWKFNTNVSFEDRTTVSLKDLQCILDDENGKCGLAHSSKPNFVLVPNFQSPFTCPIFTMAVYYYLRFHGVKKYYKGDGYQILSQLEHIPIIRGKSLDQYPRELTLGNWYPTIFKYCQLPYTKKHWFQVNQEWPQFPDFSDSSENTSTLAESDSENTIGIPDFYIEKMNRTKLQPCPQVHVHLFPTDLPPDIQAVFDLLNSVLVTSLPLLYRVFPTHDIFLDPSLKTPQNIAFLTGTLPLDIESQEHLLAQLIDKTGTVSELVPNPVKIDQNEHTLTPIGTSLSQTDIPMLDQLKTELQKLIQLQTSTGFSQLITVLLEIFQRLDFKKSNKQFVIDLLQSCRKDMRNKLMDPCSLSTNFADELSDDENEKGNKTGAIYDPETDNGNEESVSDYEPSFKKSKPNYTEEPLSDDENMEEVAQLVNQLITRKFNENLEQQTDRIISSIQPTLRDMVRTEVADALNLSLREASRDSVNKKNSDENFQNYSLTEDHFEMNPDCSDIKSIILEWFTPNRECVHSMNKKYGNKWRLTEPNLSLYRIRKPIVQYYIHLINVENLNKFDALNKLEAVLEKHHSVPLLSSFLEKAKKNGYASVT
Protein: Orthopedia homeobox a (Otpa protein) (B3DGA5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Single-minded homolog 1-A
- SIM bHLH transcription factor 1b
- Oxytocin
- Corticotropin-releasing hormone a.
- Corticotropin-releasing hormone b.
- Arginine vasopressin
- Aryl hydrocarbon receptor nuclear translocator 2
- Tyrosine 3-monooxygenase
Sequence:
MLSHADLLDARLGELSTPNSGLQLYWMKDAAAELLGHREALKCRLGGGGTDPVHPGDLAPVSDAVEGATLLPGDDINSAGSNPPGVAVNSKDQEKQQQQQQNPTQSSSQQSQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTHHGLPQFPSAAAAAAAMGDSLCSFHANDTRWAAAGMPGVSQLQLPPALGRQQAMAQSLSQCSLGAGPPPNSMSLSNMSSNGSGLQSHLYQPTFPGMVPASLSGPTNVTGSPQLCSSPDTDVWRGTSIASLRRKALEHTVSMSFT
Protein: Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) (P33778)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H2A type 1-B/E
- Histone H3.1
- Histone H2A type 2-C
- Histone H3.2
- Histone H2A type 1-C
- Histone H2A type 1-D
- Histone H2B type 1-O
- Histone H2B type 1-M
- Histone H2A.J
Sequence:
MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: DNA-directed RNA polymerase subunit (Q9M9Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369086}.
Interaction partners:
- DNA-directed RNA polymerase III subunit 2
- RNApolymerase 14 kDa subunit
- DNA-directed RNA polymerase III subunit 1
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase III subunit RPC9
- DNA-directed RNA polymerases II, IV and V subunit 6A
- DNA-directed RNA polymerases II and V subunit 6B
- DNA-directed RNA polymerases II and V subunit 8A
- DNA-directed RNA polymerase III subunit RPC6
- SIN-like family protein
Sequence:
MFYLSELEHSLRVPPHLLNLPLEDAIKSVLQNVFLDKVLADLGLCVSIYDIKSVEGGFVLPGDGAATYKVGLRIVVFRPFVGEVIAAKFKESDANGLRLTLGFFDDIYVPAPLMPKPNRCEPDPYNRKQMIWVWEYGEPKEDYIVDDACQIKFRVESISYPSVPTERAEDAKPFAPMVVTGNMDDDGLGPVSWWDSYEQVDQEE
Protein: C1orf104 protein (A2RRG2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEPGGSENAAALWISEGGRGPGRGPGPEWTSRSLLPQSGPALQPTPYSQRKGPRETHPDALKGGGGWGWGNTQSLSGECRKGVGAGEEKDGAAVSLSTPHLLAASAGLQPAPSPLGTAARCNPVP
Protein: LOC100148014 protein (NK2 homeobox 4a) (B3DG22)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MSLSPKHTTPFSVTDILSPIEETYKKFSGMESTGNLTSPLGAYRQPQVSQTGMQQHSMGHNATVATTYHMPHSVSQFSHSAMGGYCNGSIANMGDLPSYQETMRNSAAATGWYGANPDPRYSTSMNMTGMGTLTGMADTTKSIPPLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGNLCQQQQSPRRVAVPVLVKDGKPCQNGSNTPTPNQQQMQQQQNGGGVVLPTSSNSMNQHQSQQVNALVQAQDLEEMSPSPPSLHSQMNSMGQIDTSVDYTNNMVTSNLLYGRTW
Protein: Large ribosomal subunit protein mL49 (54S ribosomal protein img2, mitochondrial) (Integrity of mitochondrial genome protein 2) (Q10139)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL17m
Sequence:
MRSSLKPVLSNLRFNSTIASESLRFHVSRTPSKNLPVYLDYKQRGTKILTLIRKIHGDSNALRLRLISTLKMSPKDVYVNKLTNQVVLKGNHIVTVREWLQDQGF
Protein: APC regulator of WNT signaling pathway 2 (D4A205)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGLLGLLSLLHSTFFGNQALQELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAAQTPEGSPVHGPAPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEQEAEVPTHPEDVTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRTGTPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTQDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAVMSMFLGGPFLQGQALARTPPARQGGLEAEKETGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCTREHMTPCPLAVLTEHRDGPVCGQTRPSRLDLDLPSRAELPARDTAATDARVRTIKLSPTYQHVPLLDGAPGAGVRPLVGLGTSPGTRKQAWIPADSLSKVPEKLVASPLPVTSKVLQKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQVENLDDSDSSLEELEEAGPGEAELDRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSIPSDPCSALGSGTVSPSELPDSPGQTMPPSRSRTPPAPPGQPEASQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQDVELRLRPPACPERAVGGGGGHRRRDEATSRLDGPAPAGSRARSAADKELEALRECLGAAMPARLRKVASALVPGRRALPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETLQGPSRDKPARPGDRQKPTGRAAPARQTRGHRPKAAGAGAGKSTEHTRGANRNRAGLELPLSRPQSARSNRDGSCQTRTRGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPTRRASAIPRALKREKPAGRKETPTRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASEQPACHPRVEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPSSRRRKPRAVRSDIRPTELPQKCREEVPGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRPEKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAGESAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGLSVVTGGFPTSRHGSPSRAARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLLE