wanglab/gogpt-training-data huggingface dataset:
Protein: UBA domain-containing protein (Q57TV1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MALAHAPITGFLIGISVYYSSAAIRGHVVSQSSRTVLGWTATIKRFPILTFPLGTLGISIFDLGCALFIIIQMRKLERRWGSASFLAFVVTTAMISSFIINVCVVRGSSLSLPFEQLQVLSAAGSLMPLASLVTRFIMEVPSLDAWESFSFPLAIISKPLLTLSMLKLIVCPETELPMRTSRLRGSVIRADAGLYTRLVLTLLGVVFGLASGRQGPLAWFLGLFSRRVCRPVMRLLKPILNIVGGQSPTVELKPLKRAGNVRAATDGRYTVDNLVEGGYMNDDEAFGLWSSGGARHRRNARPMPQREGQNPTGNQQTTHRPVGGRVGDVEVDERVAQIMELGMGFSAEDIRHALSAAGGQVDVAVNVLVGA
Protein: DNA-directed RNA polymerase subunit beta' (EC 2.7.7.6) (PEP) (Plastid-encoded RNA polymerase subunit beta') (RNA polymerase subunit beta') (P0C505)
Organism: Oryza sativa subsp. indica (Rice)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Plastid, chloroplast {ECO:0000255|HAMAP-Rule:MF_01323}.
Interaction partners:
- DNA-directed RNA polymerase subunit beta''
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MIDQYKHQQLQIGLVSPQQIKAWANKTLPNGEVVGEVTRPSTFHYKTDKPEKDGLFCERIFGPIKSRICACGNSRASGAENEDERFCQKCGVEFVDSRIRRYQMGYIKLACPVTHVWYLKGLPSYIANLLDKPLKKLEGLVYGDFSFARPSAKKPTFLRLRGLFEDEISSCNHSISPFFSTPGFTTFRNREIATGAGAIREQLADLDLRIILENSSVEWKELEDEGYSGDEWEDRKRRIRKVFLIRRMQLAKHFIQTNVEPEWMVLCLLPVLPPELRPIVYRSGDKVVTSDINELYKRVIRRNNNLAYLLKRSELAPADLVMCQEKLVQEAVDTLLDSGSRGQPTRDGHNKVYKSLSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHQCGLPLEIAIKLFQLFVIRDLITKRATSNVRIAKRKIWEKEPIVWEILQEVMRGHPVLLNRAPTLHRLGIQAFQPTLVEGRTICLHPLVCKGFNADFDGDQMAVHLPLSLEAQAEARLLMFSHMNLLSPAIGDPICVPTQDMLIGLYVLTIGNRRGICANRYNSCGNYPNQKVNYNNNNPKYTKDKESLFSSSYDALGAYRQKQICLDSPLWLRWKLDQRVIGLREVPIEVQYESLGTYREIYAHYLVVGNRKKEIRSIYIRTTLGHISFYREIEEAIQGFSQAYSYTI
Protein: X-box-binding protein 1 (G5EE07)
Organism: Caenorhabditis elegans
Function: Required for transcriptional regulation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) under stressed conditions, acting downstream of ire-1, and also maintaining ER homeostasis via a negative feedback loop, in parallel with ER kinase pek-1. May also regulate Golgi protein trafficking distal to the ER. Protects the host organism from the detrimental effects of mounting an innate immune response to microbes, such as the Gram-negative bacterium P.aeruginosa, probably by modulating the UPR.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
Sequence:
MSNYPKRIYVLPARHVAAPQPQRMAPKRALPTEQVVAQLLGDDMGPSGPRKRERLNHLSQEEKMDRRKLKNRVAAQNARDKKKERSAKIEDVMRDLVEENRRLRAENERLRRQNKNLMNQQNESVMYMEENNENLMNSNDACIYQNVVYEEEVVGEVAPVVVVGGEDRRAFESAAFINEPQQWEQARSTSINNNISNQLRRMDSKKNNTISVDMYLTIISILCNHMDRNKKMDTSNKSSNISRAQAESSIDSLLATLRKEQTVMQRLVQADPCTHLQKRVKHFRRIP
Protein: Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4) (Q6P5W5)
Organism: Homo sapiens (Human)
Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:14612438, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:30874431, ECO:0000269|PubMed:31164399, ECO:0000269|PubMed:32348750, ECO:0000269|PubMed:36473915}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Apical cell membrane {ECO:0000250|UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to Zn(2+) availability. Zn(2+) deficiency promotes accumulation of SLC39A4 on the surface membrane, whereas high extracellular Zn(2+) levels induce internalization of SLC39A4, but also trigger drastic removal of cellular SLC39A4 via proteasomal and lysosomal degradation pathways. {ECO:0000250|UniProtKB:Q78IQ7, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:32348750}.
Interaction partners:
- Probable proton-coupled zinc antiporter SLC30A4
- Zinc transporter ZIP1
- Zinc transporter ZIP3
- Proton-coupled zinc antiporter SLC30A2
- Zinc transporter ZIP2
- Proton-coupled zinc antiporter SLC30A1
- Zinc transporter ZIP9
- Zinc transporter ZIP11
Sequence:
MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWASHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
Protein: histone deacetylase (EC 3.5.1.98) (M9PHQ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear pore complex protein Nup154
- NAD-dependent histone deacetylase sirtuin-1
- Smrter, isoform G
- Cyclin D, isoform D
- Protein MBD-R2
- Paired amphipathic helix protein Sin3a
- Histone deacetylase
- Histone deacetylase HDAC1
- histone acetyltransferase
- NAD-dependent protein deacetylase Sirt2
Sequence:
MSSPDDRIPIHDLPSEAGSDERLLHITPATLTLDFKPHPAVDIDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESDFPLRKTASEPNLLKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK
Protein: Microtubule-associated tumor suppressor 1 homolog (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1 homolog) (Q6IMY1)
Organism: Rattus norvegicus (Rat)
Function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).
Subcellular location: Mitochondrion {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.
Interaction partners:
Sequence:
MLLSPKFSLSTIHVRLTAKGLLRNLRLPSGLRKNTVIFHTVEKGRQKNPRSLCIQTQTAPDVLSTERTLELADYKTKCENQSGFILHLKQLLSCGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVSLRGELVAASSTCEKLEKARNDLQTAYEGFVQKLNQQHQTDQTELENRLKEFYTAECEKLQSIYIEEAEKYKTQLQEQFDNLNAAHETTKLEIEASHSEKVELLKKTYETSLSEIKKSHEMEKKLLENLLNEKQESLEKQINDLKSENDALNERLKSEEQKQLSREKANSKNPQVMYLEQELESLKAVLEIKNEKLHQQDLKLMKMEKLVDNNTTLVDKLTRFQQENEELKARMDRHMAISRQLSTEQAALQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRNSGSFSSPSISPR
Protein: Nodulin-like domain-containing protein (Q580N5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRMLMSGMYAELGVSKAYCFSIFTPFLKKKLNLTQTEVTTISTVGNCIMYFSFPSGALFDYAGPMVVLPIAGFLGFLGFLLFGLTFDRKIASPGVGLLSFFNALVYCAFPILDVSSVMPLMLQFPLDRGYIVLVSKTIGGLGTGVLMAYFNGWFKDTTSDDVEKNNYSGFAYFVAIQLVVVSLIAFVLIRLPMYFPCAWRKQRLSEEEWTKRQQTLQLYMNQPAPPRRMKTAVGLVLSLLLFLTTQSLIGGYVKLPPAAYLAFSIIAVLMMASFCVVALPFQWLGRYTPVRPTDMDTIGEALEDVVTESAVATTKNEVKPLPQYSGSFWQHLLTVDLWCMWLTCFGVWGTAVVMQMNAAQIYESKSYGEKKSSTLTLYITMISVGSAVGRMSMGYLDMVLTRRQREGLKTFPTTIALPFCPLMLCIAFLLFALLPANALILPFFLGSLGNGAGWGSVVLAFRIMYSQDLGKHYNFGFSSGIVSTIALNLFMFGGMYDAEAEKLGTKPECKNPSCVKNQMLILMGVNIVAVIAAAIVHFRFSRFINAEQNRCNEPADEMSGVAAPVTEDAGQPNEGGSHSGGAAQQ
Protein: Outer membrane protein (Q7CPS4)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Interaction partners:
- Transcriptional regulatory protein QseB
- Sensor protein QseC
- Probable HTH-type transcriptional regulator STM3175
- Glycosyltransferase
Sequence:
MKKLAAIVAVMALCSTPVLAAQQGGFSGPSATQTQGGGFVGPNGSSTTVESAKSLRDDAWVTLRGNIVERISDDLYVFKDATGTINVDIDHKRWNGLTVTPQDTVEIQGEVDKDWNSVEIDVKQIRKVNP
Protein: 3-dehydrosphinganine reductase (EC 1.1.1.102) (Q38BJ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
- serine C-palmitoyltransferase
- Serine-palmitoyl-CoA transferase, putative
- sphingolipid 4-desaturase
- Phosphatidic acid phosphatase, putative
- Phosphatidic acid phosphatase alpha, putative
Sequence:
MGVIFLVCALLIALVFAAAWWSVHRVPFFHIKGCCALVTGGSLGIGLETAKQLVKLGARVVIIAARNEQSLRAGVEALRVEAKVTGTKVEYVVMDVADEVSVEQAMDKVSKDVTAAGGKCLDLLVCNAGFSIPARFVDITPAEARRMMDVNFFGCVNVLRMVLPSMLEQRAGRVVFVSSLAARCPLAGYSVYAASKAAIRAFAHSMDMENSCRGVRFQVISPPDVYTPGFEQENIRKSPECTALSSFGGDEPVTALDMAKQIVDSIKHYRFDVSLGVDKQLLCWMVAGVEPATDVLELLLQVLLNGWLRLAMAVLSKLHYNIVWRVRKDDEKPNETSTKESERGKKVM
Protein: Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) (Q9UL19)
Organism: Homo sapiens (Human)
Function: Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Promotes keratinocyte differentiation via activation of TGM1.
Subcellular location: Membrane {ECO:0000269|PubMed:17762858}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial antiviral-signaling protein
- Cellular retinoic acid-binding protein 2
- Retinoic acid receptor gamma
Sequence:
MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA
Protein: AF4/FMR2 family member lilli (Protein lilliputian) (Suppressor of Raf at 2A) (Suppressor of sina 2-1) (Q9VQI9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11171403, ECO:0000269|PubMed:22195968}. Note=Associates to transcriptionally active chromatin.
Interaction partners:
- RNA polymerase II elongation factor Ell
- Cyclin-dependent kinase 9
- Cyclin-T
- Ell-associated factor Eaf
- ENL/AF9-related, isoform B
- Transcription elongation factor S-II
- Histone-lysine N-methyltransferase trithorax
- Little elongation complex subunit 1
- Uncharacterized protein, isoform B
- Hyrax
Sequence:
MAQQQQQQMQQQQQHHTSSINNNNSSSIVLLQQQQPQQQQQQLDQLQQYNNNLYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGDAEITAALGEFFEAREYINNQTVGISRSAPGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASATTSLPGQQQHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTNNASSGGVPASTPLGPPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITSPIAPLVTTPPQASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSGGNSSNSSESDSSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESNKWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPLPPPPTVTVAPATCNEAVQTTPPSATATSAIAPPVPATRLIYRSYFDRDVEHPSDDPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSEQATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFRVGRGDIANGNTPSSISPSNSVGSQGSGSNTPPGRIVPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHPTHQSQ
Protein: ECF sigma factor FoxI (Q9I114)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Anti-sigma factor FoxR
- Sigma factor regulator, FemR
- Probable transmembrane sensor
- FpvR
- Sigma factor regulator, VreR
- ECF sigma factor, VreI
- Metal-pseudopaline receptor CntO
- Probable transmembrane sensor
- Probable transmembrane sensor
- Probable transmembrane sensor
Sequence:
MSAPILLSAHHRAMHALYSEHHGWLQNWLRGKLGCAADAADLAQDTFLRILLKRELREIGMPRAFLRTIARGLVIDHWRREELQRAYLESIAHLPEAQAPSPEARELVLELLEEISRMLDGLKPKVRTAFLLAQCEDLSHRQIAERMGVSQRSVERYVAEALYHCYLLRYGE
Protein: Forkhead box protein A4-A (FoxA4-A) (FoxA4a) (Fork head domain-related protein 1) (xFD-1) (Protein pintallavis) (P33205)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor involved in embryonic nervous system development. Plays a role in the induction and patterning of the anterior-posterior neural axis. Involved in the establishment of floor plate differentiation from neural plate cells during gastrulation. Binds the anf1 promoter sequence to restrict expression of anf1 to the anterior of the neural plate, thereby patterning the forebrain. Can bind to the HNF-3-alpha DNA target sequence. Cooperates with t/bra in a dose-dependent manner to specify dorsal mesoderm formation, including notochord. Binds to DNA via the target sequence 5'-[GA]TAAA[TC]A-3', with 5'-GTAAATA-3' being the preferred binding site.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MLNRVKLEIKDPMDWNTMYQENEMYSGIHNMTNVLPSNSFLPNDVSTVTTSMPYMSNGLPGPVTSIQGNIGSLGSMPQGMVGSLAPPPSTAAYPLGYCQGESEFQRDPRTYRRNYSHAKPPYSYISLITMAIQQAPNKMMTLNEIYQWIIDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSPEKPGKGSYWTLHPESGNMFENGCYLRRQKRFKCERSKSGEGEKKVNKPGEETGGNLKENPVGYDDCSSSRSPQAAVNDGGRDSTGSSIHQACGSSPVGLSPTSEQAGTASQLMYPLGLSNDGYLGLVGEDVHLKHDPFSGRHPFSITQLMSSEQDQTYANKMEMCPTTDHLVHYSNYSSDYHNMASKNGLDMQTSSSTDNGYYANMYSRPILSSL
Protein: Muscarinic acetylcholine receptor gar-2 (G-protein-linked acetylcholine receptor 2) (Q09388)
Organism: Caenorhabditis elegans
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o)-alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control locomotory behavior and egg-laying.
Subcellular location: Cell membrane {ECO:0000305|PubMed:11700045}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08172}. Cell projection, axon {ECO:0000269|PubMed:18614679}. Note=Diffusely localized in axons. {ECO:0000269|PubMed:18614679}.
Interaction partners:
- Muscarinic acetylcholine receptor gar-3
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein G
- G-protein coupled receptors family 1 profile domain-containing protein
- Gamma-aminobutyric acid type B receptor subunit 1
- Gamma-aminobutyric acid type B receptor subunit 2
- Guanine nucleotide-binding protein G
Sequence:
MAVASVLLALFMLFLSIVTVIGNLAVLLSYYLDKNIRQPTNYFIFSLAISDLLIGLEGIPVYTAFYLNNNEWIWGDVLCDLWLSIDYIVCLASIYTVLGITVDRYYSVKKPATYRNWRTPGRVVLIIIFIWLVPSILFSVSIFGYGTFTGTGRILKETECYVQFMTNPYLNMGMYISYYWTTLFVMLYLYWGIYRAAKKLALKSDQKTKRLALLTEMRRPEVSVRTSDAGNSSSDSPNDTSNSSKCFRTAPPTTTVQTTQTNVGTPPPVFRNHMTLHNNNMDFTKDNEIVRPPTPPDDNTYSNPNFSMISEQLTNGFSRQEPSSVIERESTAPCVSPEPSHASLENEFNENHHAHFKPELSLPFIDADSVSSMVGHDDLRRAMSIRISRSVSMQGTARATPVIEIVENLEEALKICENLEELREDENKNEEEKQKNGLENGGMNHVIIANDEQQPSTSKESEQKEEMTPENHDPNEVKVPLIAVSRVESVKSTAGGKVRRLITQMRSHSIRSKRKANKNKSVLSALNFFQRKKEYKSRSENRARKALRTITFILGSFIILWTPFYVLATIYGFCETCKASPSFNTLYTISYYLCYMNSPLNPFCYAMANQQFKKTLTRIFKGDFRRV
Protein: Gephyrin b (EC 2.10.1.1) (Gephyrin2 isoform) (D3KYL2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Molybdopterin synthase catalytic subunit
- Glycine receptor subunit beta
- Disks large homolog 4
- Glycine receptor subunit beta
- Molybdenum cofactor biosynthesis protein 1
- Glycine receptor subunit alphaZ1
- Gephyrin
- Glycine receptor, alpha 3
- Sulfite oxidase, mitochondrial
- Glycine receptor, alpha 4a
Sequence:
MASDGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGVNLKDLVHDPSLLGGTISAYKIVPDEIDEIKETLVDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMSLAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLREAVVKVKEIPNELEDLPSPPPPLSPLPASSPHRQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAASIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKARLPSSSSTLSIAEASRREFRAHLDEVITLKSRFSTLDQLQCRLEVLKDDRRGHRTFSSRVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTAVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTHTVMPGQVMRVTTGAPIPCGADAVVQVEDTELLRESEDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVQKFPVIAVMSTGNELLNPEDDLHPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGINRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDMDGSRKLIFALPGNPVSAVVTCNLFVIPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQVSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
Protein: Negative elongation factor complex member A (A0A8I5Y6E2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHRLSSAVKLKLLLGTLHLPRRTVDEMKGALMDIIQLATLDSDPWVLMVADILKSFPDTGSLNLDLEEQNPNVQDILGELREKVSECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTTPSVFSPSGNRTPIPPSRTPLQKERGVKLLDISELNTVGAGREAKRRRKTLDTEVVEKPTKEETVVENATPDYAAGLVSTQKLGSLNSEPTLPSTSYLPSTPSVVPASSYIPSSETPPAPPSREASRPPEEPSAPSPTLPTQFKQRAPMYNSGLSPATPTPAAPASPLTPTAPPAVTPTAQTPPVAMVAPQTQAPAPVQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSRGASVLLGLGGVPTPPPAPWIGEWVPWP
Protein: Protein SCAI (Suppressor of cancer cell invasion protein) (Q8N9R8)
Organism: Homo sapiens (Human)
Function: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:19350017}. Cytoplasm {ECO:0000269|PubMed:19350017}. Note=Nuclear localization is required for inhibition of MRTFA. {ECO:0000250}.
Interaction partners:
- TP53-binding protein 1
Sequence:
MVRGARQPQQPRSRLAPRLTGTVEKPPRKRRSRTEFALKEIMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGMQESADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDSEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIIVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFIFCSATMRMHKIFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNVFFENTIDDY
Protein: NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3) (Q8WX94)
Organism: Homo sapiens (Human)
Function: Inhibits CASP1/caspase-1-dependent IL1B secretion.
Interaction partners:
- NLR family CARD domain-containing protein 4
- NACHT, LRR and PYD domains-containing protein 6
- NACHT, LRR and PYD domains-containing protein 1
- NACHT, LRR and PYD domains-containing protein 3
- NACHT, LRR and PYD domains-containing protein 12
- KH domain-containing protein 3
- Caspase-1
- Interferon-inducible protein AIM2
- Pyrin
- Apoptosis-associated speck-like protein containing a CARD
Sequence:
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC
Protein: Proteasome subunit alpha type (B5X5N7)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
- Proteasome subunit alpha type
- 26S proteasome non-ATPase regulatory subunit 8
- Proteasome subunit beta
- Proteasome subunit alpha type
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit alpha type
Sequence:
MKLISAIWSVQQSFPQDRSTMAERGYSFSLTTFSPSGKLVQIEYALAAVAAGAPAVGIKASNGVVLATEKKQKSILYDETSVHKVEPITKHIGMVYSGMGPDYRVLLRRARKLAQQYFLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLIAGWDEDRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLSPAEVKDYLAAIA