wanglab/gogpt-training-data huggingface dataset:
Protein: Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3) (B7Z0D3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
- Golgi to ER traffic protein 4 homolog
- RE23139p1
- E3 ubiquitin-protein ligase Iruka
- GM09977p
- Uncharacterized protein, isoform B
- LD24721p
- Probable ubiquitin carboxyl-terminal hydrolase FAF
- ATPase ASNA1 homolog
- Fas-associated factor 2, isoform A
- Caspar, isoform A
Sequence:
MLINLKVKTLDARIHEFSIDNELTIRQFKDQIAEKTNIAAENQRIIYQGRVLVDDKQVKEYDVDGKVLHVAERPPFSQRGANARNNDEPMRTFRNVARPPPPGMRTSPYFRALDGMLVGTMAIPVNNGPVAGTRPPPNRYPNSSSFCINRITVALHMIDCADNIAAYLENPAVGLNNQSLDILQRGRWSMESTVVEVGVSSTDLPRNNNIIDMVQDAVTAALSHTGARNYTVVQLPTVYTNENGETSQQRTAEAITSEGAASGAASNASGETTAATVIIEDVIETDDEVADGASDRSVTPTPEPEAEGAVGGQQVTAAETPTSSVGSANDAAAEGGNNSGPRRRTRPQVLAQVIQHYRGVQARLAPFVDRYYEILQNDPTFEESDTDGRENAQRIFDRVSEAFHYLSHAQHAISDLMLDLSQPGPRVLTCRPILVEQSGYIRSNNIFTPNFLAPPSGIINEPFRNRAPGSASAAGTQTATTAGTQTPTSAGTPTAVAPSQAANLQAATDASRSAAAMAEIASRAAGAAAEMAAGAASAAAGAANAAAAAARDLSSDQVEDPIDEPMVGPNAAGAETLAQEQQRLEMDHDHDQAQSETPERETRPVPRLRVYVPVTLPPPNPQLEMARIIQAMVNGQRPNDIHVEFNAPNVMSINLPVHVMTTVRQAPAAGSNETADQSASESSSPESAPASGNGESPNAASTSSGTRSGDQRANTLPTTATQTRSTSRPQIQIGGNNNWGGRIAPTHTAFDRFLPCNSHHIREPEQLLQNNSTSRSTSTAPAGGATVVPPTSAAVTRPVTTGRIQRGSNTIRPMWSSRRQRPASEQLSNLGPAAWAQAQTQTTHIPSAHVGAGSTNGAGVGAGRVRPVGGSTINRDRLATRTAHVGGGSTNGGLPSGRRGRLQAATSRLSRHLPTQLANFLINNMRNNAPTASVGSAVAAVGDTAASPSGEAAPIASTTPAAPLQTVLPTSTPTPRGDSNNLRSQLRTFLNDSLFVGVPINEQTIPGAIGRALDWFGESLVYLPQYERPEYNSRDSVCNILRVSLRLIIELCNGAPAGVDSAQFEQSLKQICDQFRKRLYSVLFLCLGSANAELYWRQLMRLLCAPMRSNFRNEALQFLCIYIDPTIPAQTDTVDAQQFLVLRSIQAAPPTAADEPFVAPPPFAFNPQQQQLQEQTLDTDVEMSEVTASGSNSSPADELPAVIVGSEPWHMSFPNDWLPVITRDLQTQAEQSNRPQPPFSDAYISGMSAKRRKIIQSEKPTASVECLIANGVQRAIQSVGLGGSNGGSALNASISMDTVIGSIAHDSTIQAAYTDAVRNSLKERTERDVDFKTSKYPQIAKFTEQK
Protein: Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) (P9WPY1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Interaction partners:
- 3-dehydroquinate synthase
- Shikimate kinase
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Probable shikimate 5-dehydrogenase AroE
- Intracellular chorismate mutase
- Secreted chorismate mutase
- Anthranilate synthase component 1
- 2-oxoglutarate oxidoreductase subunit KorA
- 3-dehydroquinate dehydratase
- Prephenate dehydrogenase
Sequence:
MLRWITAGESHGRALVAVVEGMVAGVHVTSADIADQLARRRLGYGRGARMTFERDAVTVLSGIRHGSTLGGPIAIEIGNTEWPKWETVMAADPVDPAELADVARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTVARAFLRQALGVEVLSHVISIGASAPYEGPPPRAEDLPAIDASPVRAYDKAAEADMIAQIEAAKKDGDTLGGVVEAVALGLPVGLGSFTSGDHRLDSQLAAAVMGIQAIKGVEIGDGFQTARRRGSRAHDEMYPGPDGVVRSTNRAGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGDEAVAIHQRSDVCAVPAAGVVVETMVALVLARAALEKFGGDSLAETQRNIAAYQRSVADREAPAARVSG
Protein: Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] (O88777)
Organism: Rattus norvegicus (Rat)
Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (By similarity). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Presenilin-1
- Anterior pharynx defective 1a homolog
- Gamma-secretase subunit APH-1
- Nicastrin
- Gamma-secretase subunit PEN-2
- Amyloid-beta precursor protein
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Neurogenic locus notch homolog protein 1
- Inositol 1,4,5-trisphosphate/ryanodine receptor domain-containing protein
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
Sequence:
MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYACSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVFKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
Protein: NAD(P)H-quinone oxidoreductase subunit L, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit L) (NDH subunit L) (NDH-L) (NADH-plastoquinone oxidoreductase subunit L) (Protein CHLORORESPIRATORY REDUCTION 23) (Q9CAC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18388109}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NAD
- NAD
- Photosynthetic NDH subunit of subcomplex B 2, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 3, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 1, chloroplastic
- NAD
- Photosynthetic NDH subunit of subcomplex B 4, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 5, chloroplastic
- Photosynthetic NDH subunit of lumenal location 2, chloroplastic
- Photosystem I chlorophyll a/b-binding protein 6, chloroplastic
Sequence:
MSRCGSLGLYAPNALPSLSLKPRSVKSPFCITSHTKPNDTLLHNVNKMRAKACDILGAKKTILAAQLGAVLATIDHPALAITGVNNQQELSSVVLDIGIISVWYFLVMPPIIMNWLRVRWYRRKFFEMYLQFMFVFMFFPGLLLWAPFLNFRKFPRDPNMKNPWDKPTDPDSIKNVYLKYPYATPEDYDLD
Protein: Probable G-protein coupled receptor 156 (G-protein coupled receptor PGR28) (GABAB-related G-protein coupled receptor) (Q8NFN8)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Gamma-aminobutyric acid type B receptor subunit 1
- Gamma-aminobutyric acid type B receptor subunit 2
Sequence:
MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSFHTQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECTYDLPEGAAPPASSPNKDVQAVASVHTLAAAQGPSGHLSDFQNDPGMAARDSQCTSGPSSYAQSLEGPGKDSSFSPGKEEKISDSKDFSDHLDSGCSQKPWTEQSLGPERGDQVPMNPSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQEVLQDLGLGPEASLSTAPSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSAPSSVGHRANRTVPGAHSRLHVQNGDSPSLAPQTTDSRVRRPSSRKPSLPSDPQDRPGTLEGSKQSQTEPEGARGSKAAFLRQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVPSGCASLSSQHSYFDTESSSSDEFFCRCHRPYCEICFQSSSDSSDSGTSDTDPEPTGGLASWEKLWARSKPIVNFKDDLKPTLV
Protein: O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (UGA suppressor tRNA-associated protein homolog) (Q18953)
Organism: Caenorhabditis elegans
Function: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9HD40}.
Interaction partners:
- Probable selenide, water dikinase
- Phosphoryl Seryl-TRNA
- RRM domain-containing protein
- Tr-type G domain-containing protein
- tRNA-intron lyase
- tRNA-intron lyase
- Transmembrane protein 65
- Probable serine--tRNA ligase, cytoplasmic
- serine--tRNA ligase
- tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein
Sequence:
MKANFGKKEGEYSRLVSKSSNKLLNSLWEKKQIPEEGWSEHTLDLFLSWLSSHDTNNRVDMIPVGAGEREGRVLTPLVQRLHSNLTHGIGRSGNLLEIQPKALGSSMLACLSNEFAKHALHLLGLHAVKSCIVVPLCTGMSLSLCMTSWRRRRPKAKYVVWLRIDQKSSLKSIYHAGFEPIIVEPIRDRDSLITDVETVNRIIEQRGEEILCVMTTTSCFAPRSPDNVEAISAICAAHDVPHLVNNAYGLQSEETIRKIAAAHECGRVDAVVQSLDKNFQVPVGGAVIAAFKQNHIQSIAQSYPGRASSVPSRDLVLTLLYQGQSAFLEPFGKQKQMFLKMRRKLISFAENIGECVYEVPENEISSAMTLSTIPPAKQTLFGSILFAKGITGARVVTSSQSKTTIEGCEFINFGSHTTEQHGGYLNIACSVGMTDHELEELFTRLTSSYAKFVRELAKEDERINSSGRRIPINESFDMEND
Protein: Cell adhesion molecule CEACAM7 (Carcinoembryonic antigen CGM2) (Carcinoembryonic antigen-related cell adhesion molecule 7) (CEA cell adhesion molecule 7) (Q14002)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
Interaction partners:
Sequence:
MGSPSACPYRVCIPWQGLLLTASLLTFWNLPNSAQTNIDVVPFNVAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETIYPNGTLLIQNVTHNDAGIYTLHVIKENLVNEEVTRQFYVFSEPPKPSITSNNFNPVENKDIVVLTCQPETQNTTYLWWVNNQSLLVSPRLLLSTDNRTLVLLSATKNDIGPYECEIQNPVGASRSDPVTLNVRYESVQASSPDLSAGTAVSIMIGVLAGMALI
Protein: Huntingtin interacting protein 1 (A0A8I6GA90)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDRMASSMKQVPNPLPKVLSRRGVGAGMEAAERESFERTQTVSVNKAINTQEVAVKEKHKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDASQQSLFDNKFDDIFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDNVKIESQRAMLQLKGRVSELEAELAEQQHLGRQATDDCEFLRTELDELKRQREDTEKAQRSLTEIEKKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLEREKKELADSFARTQEQQDVLETLKHELATSRQELQVLHGNLETSAQSEAKWLTQIAELEKEQGSLATAAAQREEEFSALRDQLESTQLKLAGAQDSMCQQIKDQRRILLAGARKAAELEIQEALGQLEEPALLISCAGATDHLLSKVNSVSSCLEQLEKSRSQYLACPEEISELLHSITLLGHLTSDTIIQGTATSLRAPPESADSLTEACRQYGRETLAYLSSLEEEGAMEKADTTAIANCLGKIKTIGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATTRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVASKDLQKEIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSHEIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGEPSLGHLHEKEA
Protein: Panurgin 1 (PNG-1) (C0HL84)
Organism: Panurgus calcaratus (Solitary bee)
Function: Antimicrobial peptide active against Gram-positive bacteria M.luteus (MIC=1.5 uM), B.subtilis (MIC=1.3 uM) and S.aureus (MIC=10.6 uM), against Gram-negative bacteria E.coli (MIC=3.7 uM) and P.aeruginosa (MIC=51.7 uM) as well as against yeast C.albicans (MIC=7.3 uM). Has weak hemolytic activity against human erythrocytes. Probably acts by disrupting membranes of target cells.
Subcellular location: Target cell membrane {ECO:0000305|PubMed:23483218}. Secreted {ECO:0000269|PubMed:23483218}.
Interaction partners:
Sequence:
LNWGAILKHIIK
Protein: Cadherin domain-containing protein (Q8C8Z3)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MKIGREHRKRQVLLIFLLLGVVGAGSEPRRYFVMEETPSGTVLADLVQDLGLGVAELAARGAQVVSEEKESRLQLDLQTGKLILNEKLDREELCGSTEPCVTHFQVLLKKPLEIFQAELRVGDINDHSPEFPEREMAVKIIENSPVGTAFLLKTAQDLDVGNNSVQNYKIGTNSHFHVSIRNRGDGRKYPELVLDKELDREVQAAFRLTLAALDGGSPPRTGTSQIRIVVLDVNDNAPEFAQAFYRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLFHSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGGLSGKCSVSIQVVDVNDNYPELIISSLTNPIPENSPETEVALFRIRDRDSGENGRTICSIQDGVPFTLEPSVENFYRLVTDGALDREIRAEYNITISVTDLGIPKLTTQHTITVQVSDINDNAPAFTQVSYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPQLALNSLISINADNGQLFALRALDYEALQAFEFHVSATDRGSPALSSQALVRIVVLDDNDNAPFVLYPMQNASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSASVTLQVLMVDGFSQPYLPLPEVVRDPSHQEGDVLTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGGCSVPEGHFPGHLVDVSGAGTLSQSYQYEVCLTGDSQSNEFKFLKPVFSGIVDQNYGRQPDDQSFSSVLGM
Protein: Chloroquine resistance transporter (PfCRT) (Probable transporter cg10) (Q8IBZ9)
Organism: Plasmodium falciparum (isolate 3D7)
Function: May regulate endogenous transporter.
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:Q9N623}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the parasite digestive vacuole, the site of chloroquine action. {ECO:0000250|UniProtKB:Q9N623}.
Interaction partners:
- Ferredoxin, apicoplast
- Multidrug resistance protein 2
- Cytochrome b
- Multidrug resistance protein 1
Sequence:
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIFIYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSKERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYHLYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKIDILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVENCGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDSIITQ
Protein: Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) (D0EWS6)
Organism: Sus scrofa (Pig)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU368037}. Cytoplasm {ECO:0000256|RuleBase:RU368037}.
Interaction partners:
Sequence:
MTELKAKDPRAPHVAGRAPSPTQLGTLGRPDTGPFQASQTSEASPAASAIPLSLDGLLFPGPCQGQEPDGKTQDQQSLSDVEGAYPTVEATEGAGGGSSRPSEKDTGLLDSVLDTLLAPSGPGQSHASPPACEATSPWCLFGSELPQDARVAPSTQGVLPLLMSRPEGKAGDSSGTAAAHKVLSRGLAPSRQLLPSTAGSHHWPAAAVKPSPQPAVVEVEEEDDSESEGSMVPLLKGKPRPAGGTAAGTGTPTGAPGTAAGGVALVPKEDARFSAPRGALAEHDASGAPGRSPLATTVMDFIHVPILPLNTAFLAARTRQLLEGDNYDGGAPAVSAFAPPRGSPSAPSASVTAGDFPDCAYSADDEPKDDAFPLYGDFQPPALKIKEEEEGAEAAARSPRSYLVAGANPAVFPDFPLAPPSLPPRASSRPGEASAAVAPTSASVSSASSSGSALECMLYKAEGAPPQQGPFPPPPCKPPSAGACLLPRDSLPSTSASAAAAAAAAAGAAPALYQPLGLNGLPQLGYQAAVLKEGLPQVYQPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDAVALPQSGGIPNESQALSQRITFSPNQDLQLIPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQNQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Protein: ORF123 ankyrin repeat protein (Q6TVJ7)
Organism: Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo 2000)
Interaction partners:
Sequence:
MENNDGNELNNRHPHVREFKEASLYGFLAAAADVTVEDVRRYIQFGADVNYRGAYLCTPLHVYLRSGCEKRLDVVDALLDAGADINAKEICGLTPVHLYASYAEVDVEFMRGLIERGACVGGENSVTGCLYSYLYTHSVDGGARLDVVELLVQAGADVNVSGEARKTPLHVHCAGFEVDPDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVSMATSRDARGRTPLHHHADSFRASAGIVRELLAAGCDAAAADDLGNTPLHSLATFCSCRRSVLDQLIAGGADINARNHYGHTCLYYASIYNPSVCSRLIAAGADVTARTPDGRTPLSGMIMRKHTRAVRAALATRPPADAVAASLDVAVQPEPTDATRACVRYVVLCGGTLSARVRSRHADFVRECESEVVVLRTTVVGLPGTSLLDIVRAAQPPPVLLSPRVHHVLQKLRVYTDLVDARLREMRHKTNLVDAVSRLVCPCALPPEVVRGILVHVPTDSLRHTLTLGVAQASRFLPSHK
Protein: C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3] (P80162)
Organism: Homo sapiens (Human)
Function: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
Subcellular location: Secreted.
Interaction partners:
- Growth-regulated alpha protein
- C-C motif chemokine 5
- Stromal cell-derived factor 1
- C-X-C chemokine receptor type 1
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine 10
- C-X-C motif chemokine 2
- C-X-C motif chemokine 3
- C-C motif chemokine 7
- C-C motif chemokine 8
Sequence:
MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN
Protein: CBS domain-containing protein (F4JXB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- CBS domain-containing protein CBSX3
- SNF1-related protein kinase regulatory subunit beta-3
- CBS domain-containing protein CBSCBSPB5
- Protein trichome birefringence-like 39
- Allergen-like protein BRSn20
- GDT1-like protein 5
- GMP synthase
Sequence:
MALTLLSHELSDLCIGKPPLRCLSVATATVADAIAALKSSDEPFLTVWSCNHDEKTDDNDKCECLGKICMADVICYLSKFDNNVLSLSSAFDASVSVLLPKSRALVVHVQSSCSLIEAIDLIIKGAQNLIVPIHTKSITKRRQQQKLLKRNVVVSLTNATSTTHKNSREFCWITQEDIIRFLLDSISVFSPLPSLSISDLGVINSTHTILAVDYYSSAASAVSAISRAILDNVSVAVVGKGCDQEDPCMVLIGEISPMTLACCDETAVAAVATLSAGDLMSYIDGSGPPESLVGVVRNRLEDKGMVGLISLIDSLSLSSGSSSDEESPAGKTRMTSSYGRSVSSAARMARKSVAIVCNRKSSLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFREFLDDEN
Protein: mRNA 3'-end-processing protein RNA15 (P25299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: RNA-binding component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex. Binds to A-rich RNA sequence elements.
Subcellular location: Nucleus.
Interaction partners:
- Protein PCF11
- Nuclear polyadenylated RNA-binding protein 4
- Protein CFT1
- Cleavage factor two protein 2
- Endoribonuclease YSH1
- mRNA 3'-end-processing protein RNA14
- Pre-tRNA-processing protein PTA1
- mRNA cleavage and polyadenylation factor CLP1
- Transcription factor tau 131 kDa subunit
- Poly
Sequence:
MNRQSGVNAGVQNNPPSRVVYLGSIPYDQTEEQILDLCSNVGPVINLKMMFDPQTGRSKGYAFIEFRDLESSASAVRNLNGYQLGSRFLKCGYSSNSDISGVSQQQQQQYNNINGNNNNNGNNNNNSNGPDFQNSGNANFLSQKFPELPSGIDVNINMTTPAMMISSELAKKPKEVQLKFLQKFQEWTRAHPEDAVSLLELCPQLSFVTAELLLTNGICKVDDLIPLASRPQEEASATNNNSVNEVVDPAVLNKQKELLKQVLQLNDSQISILPDDERMAIWDLKQKALRGEFGAF
Protein: Energy-dependent translational throttle protein EttA (EC 3.6.1.-) (Translational regulatory factor EttA) (P9WQK3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00847}. Note=Associates with ribosomes and polysomes. {ECO:0000255|HAMAP-Rule:MF_00847}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL23
Sequence:
MAEFIYTMKKVRKAHGDKVILDDVTLSFYPGAKIGVVGPNGAGKSSVLRIMAGLDKPNNGDAFLATGATVGILQQEPPLNEDKTVRGNVEEGMGDIKIKLDRFNEVAELMATDYTDELMEEMGRLQEELDHADAWDLDAQLEQAMDALRCPPADEPVTNLSGGERRRVALCKLLLSKPDLLLLDEPTNHLDAESVQWLEQHLASYPGAILAVTHDRYFLDNVAEWILELDRGRAYPYEGNYSTYLEKKAERLAVQGRKDAKLQKRLTEELAWVRSGAKARQAKSKARLQRYEEMAAEAEKTRKLDFEEIQIPVGPRLGNVVVEVDHLDKGYDGRALIKDLSFSLPRNGIVGVIGPNGVGKTTLFKTIVGLETPDSGSVKVGETVKLSYVDQARAGIDPRKTVWEVVSDGLDYIQVGQTEVPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLKQGGNLILLDEPTNDLDVETLGSLENALLNFPGCAVVISHDRWFLDRTCTHILAWEGDDDNEAKWFWFEGNFGAYEENKVERLGVDAARPHRVTHRKLTRG
Protein: Terminase, large subunit (DNA-packaging protein) (Gene product 2) (gp2) [Includes: Endonuclease (EC 3.1.-.-); ATPase (EC 3.6.4.-)] (P54308)
Organism: Bacillus phage SPP1 (Bacteriophage SPP1)
Function: The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging) (Probable). Once the capsid is packaged with the DNA, the terminase complex is substituted by the adapter (gp15) and the stopper protein (gp16) that form the connector (Probable).
Interaction partners:
Sequence:
MKKVRLSEKFTPHFLEVWRTVKAAQHLKYVLKGGRGSAKSTHIAMWIILLMMMMPITFLVIRRVYNTVEQSVFEQLKEAIDMLEVGHLWKVSKSPLRLTYIPRGNSIIFRGGDDVQKIKSIKASKFPVAGMWIEELAEFKTEEEVSVIEKSVLRAELPPGCRYIFFYSYNPPKRKQSWVNKVFNSSFLPANTFVDHSTYLQNPFLSKAFIEEAEEVKRRNELKYRHEYLGEALGSGVVPFENLQIEEGIITDAEVARFDNIRQGLDFGYGPDPLAFVRWHYDKRKNRIYAIDELVDHKVSLKRTADFVRKNKYESARIIADSSEPRSIDALKLEHGINRIEGAKKGPDSVEHGERWLDELDAIVIDPLRTPNIAREFENIDYQTDKNGDPIPRLEDKDNHTIDATRYAFERDMKKGGVSLWG
Protein: Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Q64346)
Organism: Rattus norvegicus (Rat)
Function: Inactivates MAP kinases. Has a specificity for the ERK family. Implicated in muscle and neuronal differentiation. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8626780}.
Interaction partners:
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 7
- Early growth response protein 1
- Protein sprouty homolog 2
- Sprouty RTK signaling antagonist 4
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST