Protein: Testis-expressed protein 15 (F8VPN2)
Organism: Mus musculus (Mouse)
Function: Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci. Not required for piRNA biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18283110, ECO:0000269|PubMed:32381626}. Nucleus {ECO:0000269|PubMed:18283110, ECO:0000269|PubMed:32381626, ECO:0000269|PubMed:32719317}.
Interaction partners:
- Testis-expressed protein 11
Sequence:
MTYFFIYVSTERACSLNNCTIAKRIGKGKDATVIFEHFRKPVDPFVQENCPCKALNSEMGPFSSDTSSSYGNVQNGNNSVLEAYNRQTENSSNLRDASQVYTHNSGFSFIPTGNTASGNGDLFSVTYLRSILSSISAAFPSHNNTGSSTVITSKLIKDPRLMKREQSMRNKSDTAGLSDVLPLDKSLGCGDSQIKLTCMPTSSISSSEVPADNTITSCLNASCFKFSSESSHYQAHNSSSKGHDCIASSSIAVTEQFKEQHSSSFPSSLSNAFSDVRKQKHSEEQVQRAQMRSNVPVLTALSSESRNSDESENTCSNDSQGHFSQESPSSDINSIYKVGHQMSTVFPAQKKGNLCEYIQDTGMMRASISTEDSTKDGVNHTWCKETVLSNETVSSPIDNSNTLYQEHKEGGNLNSLSGNCEKIGVTHKLQVPKFPISSTGDKNELYRAALELECSLTPTIECLSQKYPQHSLEHEDNTNFAMTQGLIELKTVQNNQNFGNILSDAFQEAKDVPLASEKLIDRVISSAAIDISLDSSVCNIIGEYTCVRRENENGEASPYNCHKEEASRVKDGVQDHSLSYDAELSCDLNLKINLQEQRDDKNPNEAKEHNTDNINGSEKQDCLANDHFTNIVEMREIKSNTEVEILNSEECFTFNSFRGKNGKPAETASSESEAVEQRHAPNDQRGLEHLVSSFPEIEGSSVCVASNATKQIVGTTVLTVSTSLGDHQKDELKEICSSESSDLGLVKHSISECEIDTDKDKLQDFHQLVNENSALKTGLGSEIEVDLEHDNASVFQQNMHSQGNDLCEEFELYESLKSRIDWEGLFGSSYEEIESSSFARREGTDQHSSTECNCVSFCSQDKRELHNPIFLPDLQVTITNLLSLRISPTDESLELKDNFYKQVTESTEPETNKEGNASGFGMCSQPSGENSSFSCANKFGNSVQESGDVSKSESSHSSNSSHNTHVDQGSGKPNNDSLSTEPSNVTVMNDKSKCPTKSKPVFNDTRNKKDMQSRSSKRTLHASSSRGQNIANKDLREHETHEKKRRPTSHGSSDRFSSLSQGRIKTFSQSEKHIRNVLNILNNEASLCKSKHLSRKLNKAVLHLKKAHRRVHTSLQLISKVGQKRKGPLPKAYAVIHNNFWESCDHQGDSLMSERRYSKHFLSKRKYDKQGDKRFLRFDIEESLTPVSKHRLYRTNRERIAECLSNEVMSGHVSSSLTTFHVREFCDEEQFPEPQLPLAYTSQSISQLEYTNSIVGNESSSELEHFSETSGNMLDPKETLTEKEYQTHTQLCNSDSAKLKNHTTHSIRDIAKECNSEDKTVLCESNPVYLSFIKENTSHSPDKSYDSNCKANTDIHISVLGSKKKHILSVDIYEQDNCVSDGVKSGEAIFPIEKCTVPMETTSSIPTENIASKSYTIPPVSSILVTAGEEESSVGENGLFDVNENEMNITMHSKLDLTSVTEESKICKKNMKNLSCNDSSMLLKENITGPSKRYMAKYIEEEKIRKIEQAVYKKIITEGSPISFKYKSQNKILKEKSFHVNKKIITNNLTDSHLSIKNSTVDTIALKDIPNQLKERKEAGQIKVNNNSHSDCLSKPAIVETNHRPVLHGNPKVATLQKELKEHRSPNYTSHVTELSQILQRADEAASLQILEEETKLCQNILPLFVQAFERQQECSIDQILISRKLLVEQNLWNNCRLKLKPCAVDTWVELQMAMETIQFIENKKRFLEGKPTFRSLLWYDESLYSELLRRPRGYQLQSNFYPGFQGRLKYNAFCELQNYHNQLVEFLTETKKENNSYYALLKYKRQINECEAIMKHYSDCFDFCLSVPFACGVNFGDSLGDLETLRKSTLKLISVPGGSPKVHSYPGKKDHLWIIIEIVSSKVSFIKSNEEISIKICLYGLEHIYFDAAKSLVWKEKSCSLPKKHSEKNREMEEINERAFSKLKKIYDVLSKGLNNEPTSIGLQEDAIIASKQSTLGSISNCRLNKAWLSYPDISCVGEILDQAKSADLEELQGLTLRCTDHLEILKKYFQMLQEDNIDNIFIMEENVLDMLSNHNLGAVILKPEAIEIYIEIVMISETIHYLKNLIAKKLHNQRFRGMLWFDWSLLPELIGCQEEVVSLSVGDTQTHCLWKLVETAISVLKKELAVIYEYGEASNCSYALHLFYRELKELTGVKRLLNNSKYSVSTYIDLVPHTASVNFGNTVAELEHNYKQFFLLLKNVMSVPQKDFGKMVHIIKVMKTIEHMKLLSAKDTKLSTHLLFLQMLRNKRNALQQNRQEKMETPVTEPGEDSSQPGVSEQTPPGTECTVKNISDSSKKRPVTADTCEVSQGKGNTDTVPSWKKQKVTMKDVGNIQTVSKHPSTTGSPPNDENKIGSNSSDSLKSISASPEVVKRQSSVLGSVSPAESVQDTCTPKSESKVEPTDSLPDSLASLTEQQENSNVIEKRNGNSSVAETNDKKDCPLVTCDQKDIDASYSPDHTPAQESHKTPVDHTQISPSNLTAGNDDPLVPDASLLSVSASQSEKDVYLSGTDFHHENNKILNLSTEDCTGTSSPEPVCIKDKISVLQVDKTQPIKSESPKKSMTDAPNPNTAPFGSYGNSALNVNGTVQHTHSEQNSKVLTQKVGTSRNIPPQSACSPVHNSSAHSFGTSYPYYSWCFYQYSSSNGTAVTHTYQGMTAYEIQQPPPPVLTTVASTVQSTHFNRSYSEHFSYFPGQPQANSFNPGNGYFPSHTPVSYNYQQPVYSQFASHQPVPQATYPYPPNPGAPPQVPWTYAPWQQNPFLRRP