wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor PDR1 (Pleiotropic drug resistance protein 1) (P12383)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulator of proteins involved in permeability. PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
Subcellular location: Nucleus.
Interaction partners:
- Pleiotropic ABC efflux transporter of multiple drugs
- Protein SNQ2
- Oligomycin resistance ATP-dependent permease YOR1
- Transcription factor PDR3
- Mediator of RNA polymerase II transcription subunit 15
- ATP-dependent permease PDR15
- ATP-dependent permease PDR10
- Ribosome-associated complex subunit SSZ1
- Zinc finger transcription factor YRR1
- Protein STB5
Sequence:
MRGLTPKNGVHIETGPDTESSADSSNFSTGFSGKIRKPRSKVSKACDNCRKRKIKCNGKFPCASCEIYSCECTFSTRQGGARIKNLHKTSLEGTTVQVKEETDSSSTSFSNPQRCTDGPCAVEQPTKFFENFKLGGRSSGDNSGSDGKNDDDVNRNGFYEDDSESQATLTSLQTTLKNLKEMAHLGTHVTSAIESIELQISDLLKRWEPKVRTKELATTKFYPNKSIETQLMKNKYCDVVHLTRYAAWSNNKKDQDTSSQPLIDEIFGLYSPFQFLSLQGIGKCFQNYRSKSKCEIFPRTAKETIYIMLRFFDVCFHHINQGCVSIANPLENYLQKMNLLPSTPSSISSAGSPNTAHTKSHVALVINHLPQPFVRNITGISNSELLSEMNNDISMFGILLKMLDMHKNSYQNFLMEITSNPSVAKNTQSIDVLQEFIHYCQAGEALIALCYSYYNSTLYNYVDFTCDITHLEQLLYFLDLLFWLSEIYGFEKVLNVAVHFVSRVGLSRWEFYVGLDENFAERRRNLWWKAFYFEKTLASKLGYPSNIDDSKINCLLPKNFRDVGFLDNRDFIENVHLVRRSEAFDNMCISDLKYYGELAVLQIVSHFSSSVLFNEKFTSIRNTSKPSVVREKLLFEVLEIFNETEMKYDAIKEQTGKLFDIAFSKDSTELKVSREDKIMASKFVLFYEHHFCRMVNESDNIVARLCVHRRPSILIENLKIYLHKIYKSWTDMNKILLDFDNDYSVYRSFAHYSISCIILVSQAFSVAEFIKVNDVVNMIRVFKRFLDIKIFSENETNEHVFNSQSFKDYTRAFSFLTIVTRIMLLAYGESSSTNLDVISKYIDENAPDLKGIIELVLDTNSCAYRFLLEPVQKSGFHLTVSQMLKNRKFQEPLMSNEDNKQMKHNSGKNLNPDLPSLKTGTSCLLNGIESPQLPFNGRSAPSPVRNNSLPEFAQLPSFRSLSVSDMINPDYAQPTNGQNNTQVQSNKPINAQQQIPTSVQVPFMNTNEINNNNNNNNNNKNNINNINNNNSNNFSATSFNLGTLDEFVNNGDLEDLYSILWSDVYPDS
Protein: Cell surface hydrophobicity-associated protein (EC 1.1.1.-) (B9W7H6)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Interaction partners:
Sequence:
MSIDKSKMVTRLGKSGLKVNTVAIGTMRLGSNWRGFNGDIDECLKILKFCYDNGFRTFDTADTYSNGKSEELLGLFIKKYNIPRERIVILTKCYFSVKDDAEDSTLEIDPIDFMNGKGLSRKHILAAAEASVKRLGTYIDVLQIHRLDRNVTYEEIMRSLNDVVEQGLTRYIGASSMKTWEFVELQNVAKANGWHQFISMQSHYSLLYREDERELNDYCKKNGIGLIPWSPNGGGVLCRPFDAEKTKQFLDNKQWSSLFGLDNAREADRIIVNRVEELSLKYNASMMQVSLAWCMAKGVIPIAGVSKFAQAEELVGIYNVNLTEEDIKYLEEPYHAKDLARVSE
Protein: Protein transport protein sec61 subunit alpha (P79088)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to sec62/63 complex, secretory precursor polypeptides may engage sec61 to begin membrane penetration event. A cycle of assembly and disassembly of sec62/63 from sec61 may govern the activity of the translocase (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Protein transport protein sec61 subunit beta
- Translocation protein sec63
- Probable protein transport protein Sec61 subunit gamma
- Translocation protein sec62
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL29
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1
Sequence:
MSDLRFLDLVKPFAPFLPEIAAPERKVPFKQKMLWTGVTLLIFLVMSQVPLYGIVSSDSSDPLLWLRMILAANRGTLMELGISPIVTSSMLVQLLVGSQLIEVNMELKSDREMYQLVQKFLAIIIAFGQATAYVLTGMYGRPQDLGAGICLLLILQLAAASLIVLLLDELLQKGYGLGSGISLFIATINCENIFWKAFSPTTYHIANGVQFEGAVINFVYVMFTWDNKAAALYQAFFRSGLTSSQIQLPNLWNFFATLLVFGVVIYLQDFRVEIPIRSQKFRGYRSTFPVKLLYTSNTPIMLQSALTSNLFFASRLLFNRFSSNFLVRFLGVWEQTATSGLSYYLSPPASFQDALIDPIHTLVYVFFTMFACALFSKLWIEVSGASPRDVAKQLKSQQLVMAGHREGSMYKELKRIIPTAAWLSGAVVGALAVASDLLGALGSGTAVLLCTTTIYGYYEQLQKEIKGDQYGLPVTPMMQ
Protein: Heat shock protein 60, mitochondrial (HSP60) (Q09864)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.
Subcellular location: Mitochondrion.
Interaction partners:
- 10 kDa heat shock protein, mitochondrial
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- Probable heat shock protein ssa2
- Pre-mRNA-splicing factor cwf10
- U2 small nuclear ribonucleoprotein A'
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43
- Polyadenylate-binding protein, cytoplasmic and nuclear
- U2 snRNP component prp10
- Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MVSFLSSSVSRLPLRIAGRRIPGRFAVPQVRTYAKDLKFGVDARASLLTGVDTLARAVSVTLGPKGRNVLIDQPFGSPKITKDGVTVARSVSLKDKFENLGARLVQDVASKTNEVAGDGTTTATVLTRAIFSETVRNVAAGCNPMDLRRGIQLAVDNVVEFLQANKRDITTSEEISQVATISANGDTHIGELLAKAMERVGKEGVITVKEGRTISDELEVTEGMKFDRGYISPYFITDVKSQKVEFENPLILLSEKKVSAVQDILPSLELAAQQRRPLVIIAEDVDGEALAACILNKLRGQLQVVAIKAPGFGDNRRNMLGDLAVLTDSAVFNDEIDVSIEKAQPHHLGSCGSVTVTKEDTIIMKGAGDHVKVNDRCEQIRGVMADPNLTEYEKEKLQERLAKLSGGIAVIKVGGSSEVEVNEKKDRIVDALNAVKAAVSEGVLPGAGTSFVKASLRLGDIPTNNFDQKLGVEIVRKAITRPAQTILENAGLEGNLIVGKLKELYGKEFNIGYDIAKDRFVDLNEIGVLDPLKVVRTGLVDASGVASLMGTTECAIVDAPEESKAPAGPPGMGGMGGMPGMM
Protein: Assembly/DNA maturation (O41963)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Interaction partners:
Sequence:
MPFKLFKKLTISSVVTSATVNWATLASRTVFILPKRVLPYLRSVARLTRVVIAMDRYGGLLGGFLRAVPPVQKPLSLTDGNKFREGIMSEVGKYVSTLVDPRNMMLDSFHHLKHNKSLQGSFLVHAGTVSDQEVCGTPMFCYKDGLSNPEIDRLLTPISLTRLTVPNNENSDVFRIGNIIYSEDSGLFDIIPTLRTRLMERNLHEGLVFVGPLIKNINSSFVNKITTAIKGDTVLNESLSHGLVLKLPVEQFMDFETTNTFHYTGRLPMTHRSYIYYALGYVITADGTQSLLQKFFRTPIEGPEFTRLVRDYFAGEIRNFFLGDNDFGQGNFLMFGAVCRCGYFPEDSLLTRTRVSIKGGGLSLIEIPDFTVSRGPWQFI
Protein: Non-histone chromosomal protein 6B (P11633)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:14562095}. Chromosome {ECO:0000269|PubMed:14562095}.
Interaction partners:
- FACT complex subunit SPT16
- FACT complex subunit POB3
- Non-histone chromosomal protein 6A
- Actin-related protein 7
- Actin-like protein ARP9
- High mobility group protein 1
- Chromatin structure-remodeling complex protein RSC8
- ISWI chromatin-remodeling complex ATPase ISW1
- ISWI one complex protein 3
- Imitation switch two complex protein 1
Sequence:
MAATKEAKQPKEPKKRTTRRKKDPNAPKRGLSAYMFFANENRDIVRSENPDVTFGQVGRILGERWKALTAEEKQPYESKAQADKKRYESEKELYNATRA
Protein: Growth hormone (H6UQ61)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLTPVQYLSKVFTNNLVFGTKKRVFEKLKDLEEGLQPLMRELEDRSPRGPQLLRPTYDKFDIHLRHGDALLNNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
Protein: Sex hormone-binding globulin beta form (A5JUT5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MFALKRFVVALLTLGIWVHPTLGRTLEPSPECYYFVESRSSHLLYTGNSSVGNVPILEYKVTELTSFDSEFELRTLDPEGVIFFGDIGGQQNYFLLAVIQGNLSVQTSCGDGQVLVTSGPKISDGEWKKIAVMKHEGAVAVRVGSETAVTVQQSAESQRAEIGNGMLRISIGGLLPDSGVTLGLNPPLDGCMRSWDWVRQDSSILERTLQDSKVQRCWEHIAPGSYFTGVGSVGFSSLALLGNSSAELDGADWTLSVELALRTVSARGFLFILLDTQNDYILSLKLNHPSQELMLRLRGTLFWSRSYPQTLCSGESQFLQLQVRPGQLVIGMGITKATMRLTDGDYELLKRVLSQPGSRVYLGGGPAGLSSFHGCLQAKIQGVNVDLDLAEVKHGDVRSHSCPAALDIRDGK
Protein: DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153) (P35639)
Organism: Mus musculus (Mouse)
Function: Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress. Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1547942}. Nucleus {ECO:0000269|PubMed:22242125}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000269|PubMed:22242125}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-4
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- X-box-binding protein 1
- CCAAT/enhancer-binding protein beta
- Apoptosis regulator Bcl-2
- Cyclic AMP-dependent transcription factor ATF-3
- Mitogen-activated protein kinase 14
- Nuclear factor erythroid 2-related factor 2
- Bcl-2-like protein 11
- Cyclic AMP-dependent transcription factor ATF-6 beta
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
Protein: Deformed wings (LD45751p) (Q9W4V9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Boundary element associated factor
- Centrosome-associated zinc finger protein Cp190
- Modifier of mdg4
- Transcription activator GAGA
Sequence:
MMNSKIAEVVVLNCRTCTRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGATGGSPTGGGATGGSATNLHITEVHEQPVSTSKVVMVL
Protein: BCL10 protein (A0A0C5AQN2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MDSWCITDEDMAEVKKEALERLRPYLCEKLVADRHLDYLRSRRVLTRDDAEDICCRVGNSKKTGRMLDYLAENPRGLDYLVESIRRVRTKDFVIGKITSEVEAVKRREVAISSAAGSSPPVCICKEKTPFVSLQSDSTGYKGSSEARSIQTSLSNSEDKWGQNEASFSWSALPEGVSVSSLHSLPKPGEQGAPSVPLEDNEPGTLRV
Protein: Immunoglobulin domain-containing protein oig-4 (Q5WRU0)
Organism: Caenorhabditis elegans
Function: Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation.
Subcellular location: Synapse {ECO:0000269|PubMed:21252855}. Secreted {ECO:0000269|PubMed:21252855}. Note=Secreted by body wall cells. Co-localizes with and requires acetylcholine receptors for localization at neuromuscular junctions. {ECO:0000269|PubMed:21252855}.
Interaction partners:
- Protein lev-9
- CUB domain-containing protein
- Nicotinic receptor-associated protein 4
- Uncharacterized protein
- Resistance to inhibitors of cholinesterase protein 3
Sequence:
MSFRLWGRCIFFFCFLLEAIDSRGGRRGGKGKGKSNLQFAQVAEFSLVQTVLSDNRSAQIITGSHFSQTYRLGYKLLIICKARGDPRPTIKWYKEGAEIQPKASIHYYEKPIENDTIWSKLEVDPATMGDQGVYACVANNPHGVMAKNFKAEYTY
Protein: Slow myosin heavy chain 2 (B6IDE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Actin, alpha, cardiac muscle 2
- Myosin, light chain 1, alkali; skeletal, fast
- Actin alpha cardiac muscle 1b
- Actin alpha 1, skeletal muscle a.
- Actin alpha cardiac muscle 1a
- Actin alpha cardiac muscle 1a
- Myosin light polypeptide 6 isoform X1
- Zgc:153867.
- Myosin, light chain 4, alkali
- Atrial myosin light chain
Sequence:
MGDAVMAEFGPAAPFLRKSDKERLEAQTRPFDMKKECFVPDPEVEYVKASVTSRDGDKVTVETEFGKTVTVKEVDCHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAAPGGKKDPSQEKKGTLEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRVTYQLKAERDYHIFYQILSQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDVLGFTQEEKNSIYKLTGAIMHYGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPMGIMSILEEECMFPKASDATFKAKLYDNHLGKNPNFQKPRIVKGRPEAHFALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKSTLKLLGTLFANYAGAESADSGGKGKGGAKKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPSAIPEGQFIDNKKGAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIITGIQARARGILSRIEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKIQFEAKVKELTERLEDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLTQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQALEAQLQKKLKELQARIEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATASTLRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCRTLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDLKRQLEEEVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEESLDHLESMKRENKNLQEEISDLTEQLGESGKNIHELEKVRKQLEQEKQEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDEEMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELMDVSERVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLESRVRELESEVEMEQRKASDSVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRTAEEAEEQANSNLGKFRKLQHELDEAEERADIAESQVNKLRAKSRDSGSKKGADEE
Protein: Cystatin-8 (Cystatin-related epididymal spermatogenic protein) (O60676)
Organism: Homo sapiens (Human)
Function: Performs a specialized role during sperm development and maturation.
Subcellular location: Secreted.
Interaction partners:
- Cystatin-9
Sequence:
MPRCRWLSLILLTIPLALVARKDPKKNETGVLRKLKPVNASNANVKQCLWFAMQEYNKESEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKLKRKLSCSFLVGALPWNGEFTVMEKKCEDA
Protein: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) (P67775)
Organism: Homo sapiens (Human)
Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3. Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:39032490}. Nucleus {ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:39032490}. Chromosome {ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres (PubMed:16541025). During mitosis, also found at spindle poles (PubMed:16541025). Centromeric localization requires the presence of SGO2 (By similarity). Recruited to chromatin and transcription pause-release checkpoint via its association with the Integrator complex (PubMed:33243860, PubMed:34004147). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
- Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
- Protein phosphatase methylesterase 1
- Integrator complex subunit 6
- Shugoshin 1
- Striatin-4
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Protein: G-protein-signaling modulator 2 (A0A2R8Y896)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALE
Protein: Protocadherin alpha-6 (PCDH-alpha-6) (Q9UN73)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Interaction partners:
- Protocadherin alpha-3
- Protocadherin alpha-10
- Protocadherin alpha-7
Sequence:
MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGPPKMDLMAFSPSLSPCPIMMGKAENQDLNEDHDAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Putative palmitoyltransferase ZDHHC13 (DHHC domain-containing protein 13) (DHHC-13) (Zinc finger DHHC domain-containing protein 13) (A0A0R4IQZ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Putative palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Palmitoyltransferase
- Palmitoyltransferase ZDHHC6
Sequence:
MDWSEGDGSHSHGHMGDSCHGHGGGHSHGHGHSHGGSGFGGFMPAGFHGQLVPGPMDPTQQPRKSSHPEDSSSWDIIKATQFGALERCKELVEAGYDVRQPDKENVTLLHWAAINNRADIVKYYISKGAVIDQLGGDLNSTPLHWAIRQGHLSMVIQLMRYGADPSLADGEGYRGLHLAVLFQNMPIAAYLMAKGQEVDLPDLNGQTPLMLAAQKIIGPEPTNFLIKCNASVNAVDKVNRNSPLHCAVLAGNVDSVHILLEAGASVDMQNDNGHTAIDLAQQVHSPLLIHMLSVVKTERIKANSACLKLLNRYKVCLQSVFSVVVVGAFGAILDMRTESWLLKGILLACIMAVINLASRQLATVAVRSLIPSTGLIASVFWMVVTWVLWFLPDEPSAAVQMLFTVNITAVLYYYIRSCRTDPGHVKATEEEKKKNIVVLAEAGCLDPRIFCTSCMMRKPMRANHCFSCNACVAKQDHHSIWINGCIGARNHPFFVLFLVALNFLCIWMFYGSITYWSRHCPLHYSEEGIWGALTALMGCSPWLLYVFCFVFFHTTWASILLVLQLYQIAFLGLTTSERANLMHRQRKLPQAVSLRQNPFNHGVVKNLVNFFQWRFCGLCKPMVLDWTQQHPMGLGRDMFSSPDAV
Protein: Endopeptidase Clp (EC 3.4.21.92) (Q6E6T0)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
VPYRIPGDEEATWVDLYNVMYRERTLFLGQEIRCEVTNHITGLMVYLSIEDGISDIFLFINSPGGWLISGMAIFDTMQTVTPDIYAICLGIAASMASFILLGGEPTKRIAFPHARIMLHQPASAYYRARTPEFLLEVEELHKVREMITRVYALRTGKPFWVVSEDMERDVFMSADEAKAYGLVDIVGDEMLDEHCDTDPVWFPEMFKDW
Protein: Lysozyme B (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase B) (Q8T1G6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Has antibacterial activity.
Subcellular location: Cytoplasmic vesicle lumen {ECO:0000250}.
Interaction partners:
- Putative lysozyme-like protein
Sequence:
MRISFFLLILAVIIGYAYGYSCPKPCYGNMCCSTSPGNKYYLTDFCGSTSACGPVPSCSGALYFTADSQRFGCGKHLNLCRGSKCVKAQIYDAGPAMWVEQDAGMMIIDASPTICHVLTGGSSCGWSDKFEITATVTSLTDSRPLGPFNVTEEEKAQLFIDHEIAMAQCEAEKTCNGFDLE