wanglab/gogpt-training-data huggingface dataset:
Protein: Retinoic acid-induced protein 1 (Q7Z5J4)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.
Subcellular location: Cytoplasm. Nucleus. Note=In neurons, localized to neurites. {ECO:0000250}.
Interaction partners:
- Circadian locomoter output cycles protein kaput
- WD repeat-containing protein 41
Sequence:
MQSFRERCGFHGKQQNYQQTSQETSRLENYRQPSQAGLSCDRQRLLAKDYYNPQPYPSYEGGAGTPSGTAAAVAADKYHRGSKALPTQQGLQGRPAFPGYGVQDSSPYPGRYAGEESLQAWGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQGAQVPFRTHSLHVQQPPPPQQPLAYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPTSSTYSSSVQGGGQGAHSYKSCTAPTAQPHDRPLTASSSLAPGQRVQNLHAYQSGRLSYDQQQQQQQQQQQQQQALQSRHHAQETLHYQNLAKYQHYGQQGQGYCQPDAAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPAGITDHSHFMPLLNPSPTDATSSVDTQAGNCKPLQKDKLPENLLSDLSLQSLTALTSQVENISNTVQQLLLSKAAVPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQEADYLSGSEDPLERSFLYCNQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHGSLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIGEKADKAWAEAPSLVKDSSKPPFSLENHSACLDSVAKSAWPRPGEPEALPDSLQLDKGGNAKDFSPGLFEDPSVAFATPDPKKTTGPLSFGTKPTLGVPAPDPTTAAFDCFPDTTAASSADSANPFAWPEENLGDACPRWGLHPGELTKGLEQGGKASDGISKGDTHEASACLGFQEEDPPGEKVASLPGDFKQEEVGGVKEEAGGLLQCPEVAKADRWLEDSRHCCSTADFGDLPLLPPTSRKEDLEAEEEYSSLCELLGSPEQRPGMQDPLSPKAPLICTKEEVEEVLDSKAGWGSPCHLSGESVILLGPTVGTESKVQSWFESSLSHMKPGEEGPDGERAPGDSTTSDASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPVLPKDLLLPESCTGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSPSTPGKDQRSMILRSRTKTQEIFHSKRRRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQKEGRVSQRARVPKPGAGSKLSDRPLHALKRKSAFMAPVPTKKRNLVLRSRSSSSSNASGNGGDGKEERPEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGAMKTKVLPPRKGRGLKLEAIVQKITSPSLKKFACKAPGASPGNPLSPSLSDKDRGLKGAGGSPVGVEEGLVNVGTGQKLPTSGADPLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAFTSPEALQPGGTALAPKKRSRKGRAGAHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASEDNSGGGGKKPKMEELGLASQPPEGRPCQPQTRAQKQPGHTNYSSYSKRKRLTRGRAKNTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRSDSRTPAFSPFVRVEKRDAFTTICTVVNSPGDAPKPHRKPSSSASSSSSSSSFSLDAAGASLATLPGGSILQPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRPEGTCEEASLPLERTLKGPECAAAATAGKPPRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGREDGGEEAAPADKGRKHECSKEAPAEPGGEAQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVAVDMMCSSCQEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCPKHKRLP
Protein: MAM domain containing glycosylphosphatidylinositol anchor 1 (A0A3B3IU48)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKGILLCGLDSEDLHPGLLPVNLCAFVHSANTNQTLPLWKPLFNGRDGQM
Protein: Protein kinase superfamily protein (F4HX16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}.
Interaction partners:
Sequence:
MMKLCPCFINPHQLGPNSPRDSFDEGLTAYRGHSRKLFALFTFRSHRKGSCRQKYITEEIKKYGNVKNCGRIFKFKELIAATDNFSMDCMIGEGGFGRVYKGFLTSLNQVVAVKRLDRNGLQGTREFFAEVMVLSLAQHPNLVNLIGYCVEDEQRVLVYEFMPNGSLEDHLFDLPEGSPSLDWFTRMRIVHGAAKGLEYLHDYADPPVIYRDFKASNILLQSDFNSKLSDFGLARLGPTEGKDHVSTRVMGTYGYCAPEYAMTGQLTAKSDVYSFGVVLLEIISGRRAIDGDRPTEEQNLISWAEPLLKDRRMFAQIVDPNLDGNYPVKGLHQALAIAAMCLQEEAETRPLMGDVVTALEFLAKPIEVVDNTNTTPASPTQTSSSDSSN
Protein: Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) (Q96SU4)
Organism: Homo sapiens (Human)
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:20599956}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20599956}. Note=Localizes at the Golgi-late endosome interface.
Interaction partners:
- Oxysterol-binding protein-related protein 11
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B/C
Sequence:
MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (N-linked oligosaccharyl transferase subunit 1) (Oligosaccharyl transferase 64 kDa subunit) (Oligosaccharyl transferase subunit OST1) (Oligosaccharyl transferase subunit alpha) (P41543)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:8181570}; Single-pass type I membrane protein {ECO:0000269|PubMed:29301962}.
Interaction partners:
- Protein transport protein SEC61
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1
- Protein transport protein SBH2
Sequence:
MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN
Protein: Ankyrin repeat family A protein 2 (RFXANK-like protein 2) (Q99PE2)
Organism: Mus musculus (Mouse)
Function: May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11095640}. Membrane {ECO:0000269|PubMed:11095640}; Peripheral membrane protein {ECO:0000269|PubMed:11095640}.
Interaction partners:
- Coiled-coil domain-containing protein 8 homolog
- Histone deacetylase 4
- Low-density lipoprotein receptor-related protein 2
- Histone deacetylase 5
- Obscurin-like protein 1
- Predicted gene, 19410
- Cullin-7
- F-box/WD repeat-containing protein 8
Sequence:
MATSANLDIGAQLIVEECPSSYISGMPDIKLEHQLDPNPDEGAAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSAHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLENGADPTIETDSGYNSMDLAVALGYRGVQQAIESHLLKLLQNIRE
Protein: Transcription factor SPT20 homolog-like 2 (P0C7V6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDRDLEQALDRTENITEIAQQRRPRRRYSPRAGKTLQEKLYDIYVEECGKEPEDPQELRSNVNLLEKLVRRESLPCLLVNLYPGNQGYSVMLQREDGSFAETIRLPYEERALLDYLDAEELPPALGDVLDKASVNIFHSGCVIVEVRDYRQSSNMQPPGYQSRHILLRPTMQTLAPEVKTMTRDGEKWSQEDKFPLESQLILATAEPLCLDPSVAVACTANRLLYNKQKMNTDPMEQCLQRYSWPSVKPQQEQSDCPPPPELRVSTSGQKEERKVGQPCELNITKAGSCVDTWKGRPCDLAVPSEVDVEKLAKGYQSVTAADPQLPVWPAQEVEDPFRHAWEAGCQAWDTKPNIMQSFNDPLLCGKIRPRKKARQKSQKSPWQPFPDDHSACLRPGSETDAGRAVSQAQESVQSKVKGPGKMSHSSSGPASVSQLSSWKTPEQPDPVWVQSSVSGKGEKHPPPRTQLPSSSGKISSGNSFPPQQAGSPLKRPFPAAAPAVAAAAPAPAPAPAAAPALAAAAVAAAAGGAAPSHSQKPSVPLIKASRRRPAAGRPTRFVKIAPAIQVRTGSTGLKATNVEGPVRGAQVLGCSFKPVQAPGSGAPAPAGISGSGLQSSGGPLPDARPGAVQASSPAPLQFFLNTPEGLRPLTLQVPQGWAVLTGPQQQSHQLVSLQQLQQPTAAHPPQPGPQGSTLGLSTQGQAFPAQQLLNVNLTGAGSGLQPQPQAAVLSLLGSAQVPQQGVQLPFVLGQQPQPLLLLQPQPQPQQIQLQTQPLRVLQQPVFLATGAVQIVQPHPGVQAGSQLVGQRKGGKPTPPAP
Protein: Crumbs cell polarity complex component 1 (D3ZZL8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- InaD-like protein
- Protein PALS1
- Protein crumbs homolog 2
- Crumbs cell polarity complex component 3
- Multiple PDZ domain protein
- Carbonyl reductase 1])
- FERM domain-containing protein 6
Sequence:
MNMKLKKTAYLLALYLSSSLLICVKNSFCNKNNTRCLSNSCQNNSTCKRFPQDSSCCLDTANDLDTDCEDLKDPCLSSPCQGTATCVNIPGERSFLCQCPPGYSGLTCDTATNSCGGNLCQHGGTCHKDPEHPVCICPPGYAGRFCETDHNECDSSPCHNGAVCQDRINGYSCFCVPGYQGRHCDLEVDECVSDPCMNEAVCLNEIGRYTCVCPQEYSGVNCELEIDECGSQPCLHGATCRDALGGYFCDCAPGFLGDHCELNFNECESQPCLHGGLCVDGRNSYHCDCTGSGFRGIHCESLIPLCWSKPCHNDATCEDTVDSYICHCWPGYTGALCETDINECSSNPCQFGGECAELSSQDLYGNTAGLPSSFSYLGASGYVCICLPGFTGRHCEEDIDECLPNPCLNGGTCQNLPGNYTCHCPFDDTSRTFYGGEDCSEILLGCTHHQCLNNGKCIPHFQNGQHEFTCQCPSGYAGPLCETVTTLSFESNGFLWVTSGSHTSMGSECNISLKFQTVQPNALLLVRGNKDMSVKLELLDGCVHLSIEVWNQSKVLLYISHNTSDGEWHLVEVTFAETITLALNGSSCKEKCTTKSSVSIENHQSICALQNSFLGGLPMGTASDSMSVLNIYNVPSTPSFVGCLQDIRFDLNHITLESISSGLSSNVKAGCLRKDWCESQPCQNRGRCINLWQGYRCECDRPYAGSNCLKEYVAGRFGQDDSTGYAAFKVNDNFGQNFNLSMFVRTRQPLGFLLTLGNSTYQYVCVWLEHGSLALKTPGSPKLVANFFLSDGNAHLISLRIKPNEIELYQSSQNLGFMSVPAWTIQRGDVIFIGGLPDREKTEAYGGFLKGCIQDVRLNSQNLEFFPNSTNSAQHDPVLVNVTQGCPGDNVCKSNPCHNGGVCHSLWDDFSCSCPTNTSGRACDEVQWCQLSPCPPIAECQLVPQGFECIANAAFSGLSSEILFRSNGNITRELTNITFGFRTQDTNAVILHAEKEPEFLNISIQDSRLLFQLRSGNSFYTLHLTGSQLVNDGAWHRVTFSMIDPRAQTSLWQMEVDDQTPFVISAVATGNLNFLKDNTDIYVGDQAVDNQKGLQGCLSTVQIGGLYLSYFESLHGFTSKPQEEQFLKVSTNVALTGCLPLSACHSSPCLHGGICEDSYSSYRCACLPGWSGAHCEINVDECSSSPCVHGNCSDGVAAYHCRCEPGYTGGNCEAEVDTCKSHQCANGATCVSGAQGYSCLCLGNFTGRFCRHSRLPSTVCGNEKTNFTCYNGGSCSVFQEDWKCVCRPGFTGEWCEENINECASDPCINGGLCRDLVNRFQCICDVAFAGERCELDLADDRLVGIITAVGSGTLVLLFILLLAAIVSLIASNKRATQGTYSPSGQEKAGPRVEMWSRMPPPALERLI
Protein: RIN3 protein (Q6NSK7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTARDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRCPPPPPPVLPLQPCSPAQPPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAKGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGCGGSPPCLVVREPNFL
Protein: carboxylesterase (EC 3.1.1.1) (Q8IH63)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNKDLLF
Protein: Heterogeneous nuclear ribonucleoprotein M (hnRNP M) (P52272)
Organism: Homo sapiens (Human)
Function: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Subcellular location: Nucleus, nucleolus {ECO:0000269|Ref.5}.
Interaction partners:
- BUB3-interacting and GLEBS motif-containing protein ZNF207
- Heterogeneous nuclear ribonucleoprotein H
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein U
- Heterogeneous nuclear ribonucleoprotein F
- Polypyrimidine tract-binding protein 1
- Heterogeneous nuclear ribonucleoprotein K
- RNA-binding motif protein, X chromosome
Sequence:
MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Protein: Beclin-1-like protein (Autophagy protein 6-like) (APG6-like) (Q9VCE1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a central role in autophagy.
Interaction partners:
- non-specific serine/threonine protein kinase
- Autophagy-related 14
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Autophagy-related 1, isoform B
- UV radiation resistance-associated gene protein
- RB1-inducible coiled-coil protein 1
- Autophagy-related protein 9
- BG1
- Ubiquitin-like-conjugating enzyme ATG3
- Autophagy protein 12-like
Sequence:
MSEAEKQAVSFACQRCLQPIVLDEQLEKISVHAMAELSLPIYGDNGNTLDPQDASSFDHFVPPYRLTDSINGTGFMLVSDGRDNKKMSAAFKLKAELFDCLSSNSEIDHPLCEECADSMLEIMDRELRIAEDEWDVYKAYLDELEQQRVAPNVEALDKELDELKRSEQQLLSELKELKKEEQSLNDAIAEEEQEREELHEQEESYWREYTKHRRELMLTEDDKRSLECQIAYSKQQLDKLRDTNIFNITFHIWHAGHFGTINNFRLGRLPSVSVDWSEINAAWGQTVLLLSALARKIGLTFERYRVVPFGNHSYVEVLGENRELPLYGSGGFKFFWDTKFDAAMVAFLDCLTQFQKEVEKRDTEFLLPYKMEKGKIIDPSTGNSYSIKIQFNSEEQWTKALKFMLTNLKWGLAWVSSQFVSP
Protein: Condensin-2 complex subunit H2 (Non-SMC condensin II complex subunit H2) (Q641G4)
Organism: Xenopus laevis (African clawed frog)
Function: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MDDAESRFTHLLQPVRDLTKNWEVDVAAQLGEYLEELDQICISFDGGKTTMNFAEAALLIQGSACIYSKKVEYLYSLVYQALDFISNKKRVQQPTSVGADGEDKDATFAHRNDEEEFLSLDDIDSKKTNVDLKKDHILNVVNIVPLTPMALVPPEEVEKKNNPLCSRKGEVLASRKDFRMNTCTPHPSGAFMLELVGKSPMQFLKHIQHQEEVSLTQGEQNAIPEGENDNMESEKSDCADPVQVLQFSDEGAPAVENGDGTGFLPLDDHDEAGDGEVEQAEHIERRKMQIDERGYILRDRVAEQKPTPAIKNETPDPWCVLDPFESCEEKPFKKGKHYTLPRGIAEDLSSNKRKRKLPCKLQDFMKWFSSTHWDGSEAMKSRRKGPTFADMEVLYWKHIKERMTAQRQLHRRMGAQFVKEVTLLNEEEELVDPLEEPRDADCLEYDGPADDASDNEDLGENVPACLREEPALGDIEPVTLQDQLSYEELVRRNVDLFIANSQKYAQETVLSLRVREWEDKMGPQLQEQEEHSAFDIHDYGDRLTAQYSRVGEWHTFASLMADKEPYEVCRYMLASLQLANDYTVEVSQKPGLHEGLDTMALRLLSQQRAHERFKTYTAPSISQQ
Protein: glutamine--tRNA ligase (EC 6.1.1.18) (F4ICG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVLKDDNSEKSIELFISIGLDEKTARNTINNNKVTANLTAVIHEAAVTDGCDRNTGNLLYSVATKFPTNALVHRPTLLKYIVNSKIKTPAQLEAAFAFFASTGPEDFKLNEFEEACGVGIEVSPEDIEKAVKGIFEENKKTILEQRYRTNVGELFGHVRKSLPWADPKIVKKLIDEKMYELLGEKTAADNEKPTKKKEKKEKPAKVEEKKAVVETTAEPSEEELNPYTIFPQPEQNFMVHTEVFFSDGSILRCSNTKEVLDKHLKVTGGKVYTRFPPEPNGLWFYVRFQCLYFQAMFVDFGLAKERGGCCYLRYDDTNPEAEKEEYINHIEEIVKWMGWEPFKITYTSDYFQELYDLAVELIRRGHAYVDHQTADEIKEYREKKMNSPWRDRPIEESLKLFDEMRRGIIEEGKATLRMKQDMQSDNFNMYDLIAYRIKFAPHPKAGDKWCIYPSYDYAHCTVDSLENITHSLCTLEFETRRASYYWLLHSLSLYMPYVWEYSRLNVTNTVMSKRKLNYIVTNKYVDGWDDPRLLTLSGLRRRGVTSTAINAFVRGIGITRSDGSMIHVSRLEHHIREELNKTAPRTMVVLNPLKVVITNLESDKLIELDAKRWPDAQNDDPSAFYKVPFSRVVYIDQSDFRMKDSKDYYGLAPGKSVLLRYAFPIKCTNVVFADDNETVREIHAEYDPEKKSKPKGVLHWVAESSPGEEPIKVEVRLFEKLFNSENPAELNDAWLTDINPNSKMVISGAYAVSTLKDAAVGDRFQFERLGYYAVDKDSEPGKLVFNRTVTLRDSYGKGGK
Protein: Exportin-T (Exportin(tRNA)) (tRNA exportin) (Q586K4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU366037}. Nucleus {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
Interaction partners:
- GTP-binding nuclear protein
- Tyrosyl/methionyl-tRNA synthetase, putative
- Poly
Sequence:
MSQLSSPIVFSMESFTQAMELTHTYQPGVTQQQRQEAEQYLMELRVTADGLNLAFGIINSEPVQDTCCFWAFNTIMHHLPRIARDVDDTKAEELYKTLFSFIYRYFFSSNAPTSVSGASLIGLTATSSSTVNCTVLSGVATGTRQRQSIDYLANKHAQMMVAGLQEFFPSRWRSFFDDAFELINRGASLQQHIRDSVTLYILRLFEYIDERVVSVRERSDRSRDQRARDMELKDAMREHVIPRATAFWHATLCECRQRVPELANICMSIVQTYIEWVDISLFFTAEWINLLYFMLSADTVRGAACECLCGLVEKKQVSAAKLESLRKLNVVDAVPRVVSLVPAPPESDEDVNFTESVAKLVREVSMQFLSLYEHITSNRNNYASWGGVSGARGNHANMSHNSSSAETATSPPSLSCVRSTESLDAEGGIDCTNVDCRNFQGRQQQQHSYFVPDGHLSVEFLGEVQVALDVVVPELLRLLSIRHDVVVDTLIPFIQMYIKSSALREEQAAQLLRALYDHTVIGGVAENEEPFWMDDIIDRRKQMHNIMRLLFRDHPAVVMPHLREVVARAASSASDPTTTSAEGFGQTGVMGQDKDLKSHGIDNISNGRGLNCEGISAAVGGSSNTASSPEEAEAALRYLYELGESFRMEQLRDSSNEFAQLIFAVLTSEHLPQHTCSVVHVSYFEVLDRYCVFFTYHRNYIPLLLQRLLLMPHGVMNSSPNVRARICYLFGHLVQVLKSSLVPHVQDIITALQRILAATEYLLPSNRRDLYEAIGILLSTVPQLPAAGATEGTAMTLHVVQVVRQNLRDASVVGNIACAEAVADGISFLTALVKGLRGGGGGGSSGSGAAVNNATYTSPNKNSSGSGSNACSESIKINNATDGNSVSESTGEAVVAEVFHNVTSDVMEVFSTWHASPSVRDRIVQYFTQMAHLLPFDSMKVYVPVYTSNWLMWMEAVQELIKLLRFLLQFIHRSGPCVAEILSQLMPPLLEKVSAVGELSAEDDQSDIVSETMREQRDVYRQLFAVVHGAAQAQCAHVILFLPSVNLNALLVQLLTAIQLPGETELPKIALQIMTKVTATVEPCCTNNESSGAGRHPLRNDCSQGSTGAAGEAWMKFMLNDALRVVFARMFSPTFDLKDAKSLLFIGETGLLLKALMNKLGPADASLSVMLYETFSPLVGESEATGFISALQQQPGRFSTEMKVRFCNMLKFARQHYAA
Protein: Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) (P48160)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein eL19
Sequence:
MPTRFSKHRKSRGDVCAGYGRVGKHRKHPGGRGNAGGLTHHRINFDKYHPGYFGKLGMRHFHLLRNQYHCPTVSLEKIWTLVPESVRKSLAAKNDGTAPVVDVTQKGFFKVLGHGILPTQPIIVKARYFSKVAEKKIKAVGGACILVA
Protein: Pickpocket 23, isoform C (A8JV41)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Gustatory and pheromone receptor 32a
- Gustatory and pheromone receptor 33a
- Gustatory receptor for bitter taste 66a
- IP13856p
Sequence:
MPQEKRHPPESRTQRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKVLSQSIPQNLLDAHTIREWAFEGHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQIDWSEPQLVEVRISKKNTYTTDDARQLSIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVPMCSIKDFDCLDEFKSNITNIKDCLQCELSCSKTVFNIDKLIKMSDRPESLGVLVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCMVYKNRQELYEIEEKIRQEPPPKIDLKLSLKSHNPRIGDTPTSAVLKVKPAEESAGPNPLGGYQRKHEKDYSLNTKNYYKTPKVVPDYGYTSKTKNSWTTYDHSQYMP
Protein: Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) (Q9H334)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling. Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA.
Subcellular location: Nucleus {ECO:0000269|PubMed:25027557, ECO:0000269|PubMed:26647308}. Note=Not found in the nucleolus. {ECO:0000269|PubMed:26647308}.
Interaction partners:
- Forkhead box protein P2
- Forkhead box protein P4
- Immunoglobulin heavy variable 4-38-2
- T-box brain protein 1
- Interleukin-1 family member 10
- Nuclear receptor corepressor 2
- Forkhead box protein P3
- Importin subunit alpha-8
Sequence:
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME