wanglab/gogpt-training-data huggingface dataset:
Protein: Insulin-2 [Cleaved into: Insulin-2 B chain; Insulin-2 A chain] (P01326)
Organism: Mus musculus (Mouse)
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular location: Secreted.
Interaction partners:
- Insulin receptor substrate 1
- Insulin-like growth factor 1
- Insulin-like growth factor 1 receptor
- Insulin receptor
- Insulin-1
- Insulin receptor substrate 2
- Pro-epidermal growth factor
- Appetite-regulating hormone
- Insulin-degrading enzyme
- Cation-independent mannose-6-phosphate receptor
Sequence:
MALWMRFLPLLALLFLWESHPTQAFVKQHLCGSHLVEALYLVCGERGFFYTPMSRREVEDPQVAQLELGGGPGAGDLQTLALEVAQQKRGIVDQCCTSICSLYQLENYCN
Protein: Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2) (Q9Z265)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (By similarity).
Subcellular location: Nucleus, PML body {ECO:0000250}. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53. {ECO:0000250}.
Interaction partners:
- Serine-protein kinase ATM
- Cellular tumor antigen p53
- Serine/threonine-protein kinase ATR
- Breast cancer type 1 susceptibility protein homolog
- TP53-binding protein 1
- Serine/threonine-protein kinase Chk1
- M-phase inducer phosphatase 3
- M-phase inducer phosphatase 1
- M-phase inducer phosphatase 2
- E3 ubiquitin-protein ligase Mdm2
Sequence:
MKSHHQSHSSTSSKAHDSASCSQSQGGFSQPQGTPSQLHELSQYQGSSSSSTGTVPSSSQSSHSSSGTLSSLETVSTQELCSIPEDQEPEEPGPAPWARLWALQDGFSNLDCVNDNYWFGRDKSCEYCFDGPLLRRTDKYRTYSKKHFRIFREMGPKNCYIVYIEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDAEDYYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWLQDEYMKKKFQDLLVQEKNSVTLPVAPAQTSSQKRPLELEVEGMPSTKRLSVCGAVL
Protein: Large ribosomal subunit protein mL101 (rPPR4) (Pentatricopeptide repeat-containing protein At1g60770) (O22714)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000303|PubMed:36423343}.
Interaction partners:
- Small ribosomal subunit protein mL104
- Uncharacterized protein
- Small ribosomal subunit protein mS80
- AT5g49210/K21P3_8
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL3m
- At1g64880
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein bS18c
Sequence:
MAMRHLSRSRDVTKRSTKKYIEEPLYNRLFKDGGTEVKVRQQLNQFLKGTKHVFKWEVGDTIKKLRNRGLYYPALKLSEVMEERGMNKTVSDQAIHLDLVAKAREITAGENYFVDLPETSKTELTYGSLLNCYCKELLTEKAEGLLNKMKELNITPSSMSYNSLMTLYTKTGETEKVPAMIQELKAENVMPDSYTYNVWMRALAATNDISGVERVIEEMNRDGRVAPDWTTYSNMASIYVDAGLSQKAEKALQELEMKNTQRDFTAYQFLITLYGRLGKLTEVYRIWRSLRLAIPKTSNVAYLNMIQVLVKLNDLPGAETLFKEWQANCSTYDIRIVNVLIGAYAQEGLIQKANELKEKAPRRGGKLNAKTWEIFMDYYVKSGDMARALECMSKAVSIGKGDGGKWLPSPETVRALMSYFEQKKDVNGAENLLEILKNGTDNIGAEIFEPLIRTYAAAGKSHPAMRRRLKMENVEVNEATKKLLDEVSQDV
Protein: Germacrene A synthase (TpGAS) (EC 4.2.3.23) (F8UL80)
Organism: Tanacetum parthenium (Feverfew) (Matricaria parthenium)
Function: Sesquiterpene synthase involved in germacrene A biosynthesis. Germacrene A is a precursor of several sesquiterpene lactones.
Interaction partners:
Sequence:
MAAVQATTGIQANTKTSAEPVRPLANFPPSVWGDRFLSFSLDKSEFERYAIAMEKPKEDVRKLIVDSTMDSNEKLGLIYSVHRVGLTYMFLQEIESQLDKLFNEFSLQDYEEVDLYTISINFQVFRHLGYKLPCDVFKKFKDAISGTFKESITSDVRGMLGLYESAQLRIRGEKILDEASVFIEGKLKSVVNTLEGNLAQQVKQSLRRPFHQGMPMVEARLYFSNYEEECSSHDSLFKLAKLHFKYLELQQKEELRIVTKWYKDMRFQETTPYIRDRVPEIYLWILGLYFEPRYSLARIIATKITLFLVVLDDTYDAYATIEEIRLLTDAMNKWDISAMEQIPEYIRPFYKVLLDEYAEIGKRMAKEGRADTVIASKEAFQDIARGYLEEAEWTNSGYVASFPEYMKNGLITSAYNVISKSALVGMGEIVSEDALAWYESHPKPLQASELISRLQDDVMTYQFERERGQSATGVDAYIKTYGVSEKKAIDELKIMIENAWKDINEGCLKPRQVSMDLLAPILNLARMIDVVYRYDDGFTFPGSTLKEYINLLFVDSLPV
Protein: DUF5642 domain-containing protein (O05582)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Acyl-CoA:diacylglycerol acyltransferase
- Secreted protein
- Acetyltransferase Pat
Sequence:
MRPPLAPQFAADLLVKTVSTLRSSGAALGRLTTMRKAVLAVGSVCWLVGCSSGASSTTASTGDIAKVAEVKSGFGPEYTVTDVTPRAIDPGFFSARKLPDGLSFDPANCAQVAAGPQLPTGLQGNMAAVSAEGNGNRFVVIAVETSQPLPAPSPGKDCSKVTFSGTQLRGGIEVVDVPHIDGTQTLGVHRVLQAVVGGSARTGELYDYSARFGDYQVIVIANPLVIPGRPVARVDTQRARDLLVQAVAAVRG
Protein: Hemoglobin subunit beta-H0 (Beta-H0-globin) (Hemoglobin beta-H0 chain) (P04443)
Organism: Mus musculus (Mouse)
Function: This is a minor early embryonic beta chain.
Interaction partners:
Sequence:
MVHFTAEEKAAITSIWDKVDLEKVGGETLGRLLIVYPWTQRFFDKFGNLSSAQAIMGNPRIKAHGKKVLTSLGLAVKNMDNLKETFAHLSELHCDKLHADPENFKLLGNMLVIVLSSYFGKEFTAEAQAAWQKLVVGVATALSHKYH
Protein: Cytochrome P450 CYP94D108 (PpCYP94D108) (EC 1.14.14.-) (A0A517FNC7)
Organism: Paris polyphylla (Daiswa polyphylla)
Function: Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e.g. furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones. During the 5,6-spiroketalization of cholesterol, may catalyze the 27-monohydroxylation of furostanol-type steroid to an intermediate product that undergoes a stereospecific formation of the terminal heterocycle to yield diosgenin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDPPSLLSLALLLLAAAAAAAFVLFPRRRSPEKKPSSGNPGSLSELIKNGHRILDWMVEILAASPTNTVATYMGVVTANPANVEHMLKTKFENYPKGDRFVTLLEDFLGRGIFNSDGDHWKLQRKTASLEFNTKTIRTFVMENVRVSVVDRLIPIFARAAASGETIDLQETLERFAFDNVCKVSFNEDTGRLSGDDTMEGREFARAFEQASELIVGRYKHPFLLSWKLMRFFNIGDERRLKEKIATVHRFATSVIRRRKSAASLGDDLLSRFIAEADYPDEFLRDIIISFVLAGRDTTSATLTWFFWLASTRPEVLARVEAEVNAVRRKNGTCAGVMFTLEEVREMDFLHAALSEALRLYPPVPLQTRACHESDEFPDGTKVRPGTTVMYNSYAMGRMKSIWGEDYAEFRPERWLDKGGGFQPRSPFRFPVFHAGPRMCLGKEMAYIQMKAVAASVVERFEVVVMDKEKVREKDYTMILRVKGGLPVRLKEKSVAAG
Protein: LIM domain-containing protein C (Q9BIW5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to F-actin and may modulate the chemotactic response during early development and contribute to the maintenance of the strength of the actin cytoskeleton.
Subcellular location: Cell projection, pseudopodium {ECO:0000269|PubMed:12374734}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12374734}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12374734}.
Interaction partners:
- SAP DNA-binding domain-containing protein
- Paxillin-B
- Calponin-homology
- Calcium-regulated actin-bundling protein
- LIM domain-containing protein D
- LMBR1 domain-containing protein 2 homolog B
- Uncharacterized protein
- Ankyrin repeat-containing protein
- Phospholipase D B
Sequence:
MSSICPTCTKRVYAAEAVKACEKQYHKLCLQCFHCHKILQLGQYSERDGQPYCKTDYDRLFRQAGYRGGGVVADSFEPAPKVETTTPVEPTPPPTFLTPTEEVKVQLFPTNCPKCGKKAYFNELKVYNSRDWHKTCFACFSCNKNLVSGQYSEKEGLIYCPRCYQSKFGPSGYTNTGALVLH
Protein: Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 8 (AtCand8) (F4K2U8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: G-protein coupled receptor. Plays a role in plants and microbes interactions (By similarity).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 6
- Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 7
- AT3g59090/F17J16_140
- Heptahelical transmembrane protein 5
- Heptahelical transmembrane protein 2
- Tobamovirus multiplication protein 3
- At3g09570
- G-protein coupled receptor 1
- Heptahelical transmembrane protein 1
- LanC-like protein GCR2
Sequence:
MRVLDEIAESPFLISPLNPNSTANGYRWVDKCHGFLHNTVLVAASLFFVAYLAYEAKKSLSKLSNRRSYIMIAYYGCLWLVSLLNLAWCCLQGWECTPGKEVVWNLLTLFTTSGMLFLEVSLVAFLFQGNYASGAEALTRTFLISGFIVALDLLLKAIFLFGFGVPLFIDNNENGKTFKWGLWIIHKLLLTGVYGMVFLMYNSRWREKLPARPAFYNYIIIMFALYSLYLVASAFTANNAHFGFWLYGIMSVCYHALYLPLLYITFLADFFQEEDLNLENVYYSEMKDAGFFDSDWE
Protein: SD03196p (Q95R75)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENATRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFCDRQLMQALVFDARVTGWFSNNTSFNSKDDKGNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFDAGESNSEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNACAVDDKDCYILDNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASSMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYNMTAHACERPFVVLPIPFSNLILLVIDQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIKLCGKACSVYANLGLLLLCHILSRWL
Protein: Protein singles bar (Q9VXD1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for myoblast fusion in developing embryos and pupae, and consequently is essential for muscle formation in adults. Required for progression past the pre-fusion complex stage of myoblast fusion.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASFGVRGMGQPLGIRICCCRVCTCINFGFVLSRIGLLKLMQLGLAMLCEGLLIRYGVPYADSIGQALTSFLATTGHCFTTTGILLLCYAFSDKSYSLIRQSLFETLFNGLASCMYFSSSSYMGFACVVWLHPQFLVRPGFWAYPAMTACYYMGYAAGILHALDAYLAFRHFRGAR
Protein: SPT3 homolog, SAGA and STAGA complex component (Q5VWT9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPLSPFTISFSLTECLPQEWDGFSSLLM
Protein: Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Q8K0S5)
Organism: Mus musculus (Mouse)
Function: Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12839991}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q80WD0}. Membrane raft {ECO:0000250|UniProtKB:Q86UN2}. Perikaryon {ECO:0000250|UniProtKB:Q80WD0}. Cell projection {ECO:0000250|UniProtKB:Q80WD0}. Note=Localized to the surface of neurons, including axons. {ECO:0000250|UniProtKB:Q80WD0}.
Interaction partners:
- Reticulon-4
- Receptor-type tyrosine-protein phosphatase S
- Receptor-type tyrosine-protein phosphatase F
- Myelin-associated glycoprotein
- Cystathionine gamma-lyase
Sequence:
MLRKGCCVELLLLLLAGELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPEDSERIFLQNNRITFLQQGHFSPAMVTLWIYSNNITFIAPNTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGNAWDCGCRARSLWEWLRRFRGSSSAVPCATPELRQGQDLKLLRVEDFRNCTGPVSPHQIKSHTLTTSDRAARKEHHPSHGASRDKGHPHGHPPGSRSGYKKAGKNCTSHRNRNQISKVSSGKELTELQDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSGTALGAPLLAWILGLAVTLR
Protein: Actin-depolymerizing factor 4 (ADF-4) (AtADF4) (Q9ZSK3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers. Contributes to the stochastic dynamic turnover of actin filaments. Binds monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin. Involved in resistance triggered by the effector AvrPphB of Pseudomonas syringae pv tomato (Pst). May modulate the AvrPphB-RPS5-mediated defense signal transduction pathway. During AvrPphB-triggered resistance signaling pathway, involved in the control of MPK3 and MPK6 activation, via the coordinated regulation of actin cytoskeletal dynamics and RPS5 resistance gene transcription. During innate immune response triggered by the bacterial elf26 peptide, the inhibition of ADF4 regulates actin dynamics in order to execute key events associated with pattern-triggered immunity (PTI), such as cell wall fortification and transcriptional activation of defense gene markers.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19346440}.
Interaction partners:
- Profilin-2
- Profilin-1
- Profilin-4
- Profilin-3
- Profilin-5
- Cyclase-associated protein 1
- Villin-5
- Villin-1
- Protein phosphatase EYA
- Uncharacterized protein F9K21.80
Sequence:
MANAASGMAVHDDCKLRFLELKAKRTHRFIVYKIEEKQKQVIVEKVGEPILTYEDFAASLPADECRYAIYDFDFVTAENCQKSKIFFIAWCPDVAKVRSKMIYASSKDRFKRELDGIQVELQATDPTEMDLDVLKSRVN
Protein: Nescient helix loop helix 1 (Q5T203)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMLNSDTMELDLPPTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV
Protein: NADH-quinone oxidoreductase subunit B (EC 7.1.1.-) (NADH dehydrogenase I subunit B) (NDH-1 subunit B) (NUO2) (P0AFC7)
Organism: Escherichia coli (strain K12)
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- NADH-quinone oxidoreductase subunit F
- NADH-quinone oxidoreductase subunit E
- NADH-quinone oxidoreductase subunit A
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit I
- NADH-quinone oxidoreductase subunit C/D
- NADH-quinone oxidoreductase subunit J
- NADH-quinone oxidoreductase subunit N
- NADH-quinone oxidoreductase subunit K
- NADH-quinone oxidoreductase subunit G
Sequence:
MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI
Protein: SH3 domain and tetratricopeptide repeat-containing protein 2 (Q80VA5)
Organism: Mus musculus (Mouse)
Interaction partners:
- Myotubularin-related protein 13
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Polyphosphoinositide phosphatase
- Ganglioside-induced differentiation-associated protein 1
- FYVE, RhoGEF and PH domain-containing protein 4
Sequence:
MGGCFCIPGERSLPWGPGKEGSSKDPPGLAEDTSSLENKRKCFLPQNMTQDLVLSFCVKSRSRRCVNAALQEAARRRLWALENEAQEVHALFKDLSARLVSVQSQKDQFLITFKTLEEIWKFSTYLNLGYVSICLEHLFFDHTYWLNSRLVDDTEIQVSVDDNHLENIYLGLLLQEGHFFCRAVCSVAQPADKEGEYLTLCKNELISVLSGGESECEAMSLVTGQRGLVPMSALEPLPVPFHQWFLKNHPGICGLPRKRDWTGSGQIGRGRCKALMDYEQEERDELCFLQGESIDVIGFVIPGLQWFIGKSVSSGEVGFVPTRSIDLDSCSPMSKNSAFFSDEERSSLWSPGSERKAECSGFLCSLAHTDITSIYRLSEFEAIQNLQNDLSASQPEGFREARSGGTWMERQTIGSRRSSGSGDSSPEEDELISASSDSYHLPEPEDLDDPELFMDLSTSLEEDDVEHFAPILAFLDHEGYTDHFKSLYDFSFSFLTSSFYSFSEEDELVAYLETSRKWAKMSHMTWAHARLCFLLGRLSIRKTKLSQARVYFEEAIRVLDGAFEDLSLVAALYINLAAIYLRQRLRHKGPTLLEKAGALLACLPDHEFSTKNELDVVTYVLRQGIVVGSGLLEARSCFLAIRLLLSLGRHEEVVPFAERLQLLSGHPPASEATATMLSSLYDKKYLPHLAVASVQKRGPQSARGMSLSIWQAYLVLQNATKILGVPSSNWCEVSALACPTLRQALAACEELSDQDIQRTLCLILSKMYLQHQSPDGSVHYLSQAHVLGKLLGEEEAFESSLCLAWAYLLGRQTEKALEILEPLLCSLRETECVTQRGVVHNLLGLAFEDEGRTSRAAKSYLRALIRAREMGNIRNQAVSMANLGHLTLKSCMQQSARGYLLQAVRLYSELQASKETDMELVQVLLWLGQASVSGHQLVHSRLCYEMALLFGLRHQHLSSQLQVTKSLCHFYSSVSPNPDACITYHEHWLALAQQLRDREMEGQLLESLGQLYRNLNTSRSLRRSLACIKESLRIFVDLGERDKAAEAWLGAGRLHYLMQEDELVELYLQEAIQTALRSEEPSLALKLYEEAGDVFFNGTRHRHRAVEYYRAGAVPLARRMKALRTELRIFNKLTELQISLEGYEKALEFATLAARLSVLTGDQKQELVAFHRLATVYFSLNMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYCRLGRLTFYQLKDAHDATEYFLLALAAAVLMGDEELQNTIKNRLDSICQSPLWHSNPFGCSSERARWLSGGSLAL
Protein: Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) (O15403)
Organism: Homo sapiens (Human)
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q7TMR7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV
Protein: Os01g0707500 protein (cDNA clone:001-207-E08, full insert sequence) (Q8S0N2)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
METFGWAGGGQLMHHDDIYLPRSVGCGRPFELDDAFLGACFGAQLQCDGGVGGGDGGGCLQGTSGFGAVAGDPLGLLCSGDVFASVAEGAGGAHDDGLLDAALAFSRNQLGGAACDGSDGGAVSNGAMLSSYSGTTGGNISSGESNNYSGGGGGYDAEVVSPTSTMSAATQSLHPKRKLYDDHHHPAGIAAAAAAPPLAPCPRPTTGAVAAKRRASTSATSITFGHQPHHHHAGATTAGYEPDMEAMAQVKEMIYRAAAMRPVHLGTEAAADKPRRKNVRISSDPQTVAARLRRERVSDRLRVLQKLVPGGNKMDTASMLDEAASYLKFLKSQVQKLETLGTTTTTSKLPQQYYSGNINSSNNHHGFLGFAANNNTISAGYANSNAGNATKLL
Protein: RuvB-like helicase (EC 3.6.4.12) (A0A384MTR5)
Organism: Homo sapiens (Human)
Subcellular location: Dynein axonemal particle {ECO:0000256|ARBA:ARBA00024190}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363048}.
Interaction partners:
Sequence:
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Protein: Putative pyrimidine permease RutG (P75892)
Organism: Escherichia coli (strain K12)
Function: May function as a proton-driven pyrimidine uptake system.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Ureidoacrylate amidohydrolase RutB
- Probable malonic semialdehyde reductase RutE
- FMN reductase RutF
- 3-aminoacrylate deaminase RutC
- Putative carbamate hydrolase RutD
- Pyrimidine monooxygenase RutA
- Guanine/hypoxanthine permease GhxQ
- Putative purine permease YbbY
- Adenine permease AdeQ
- Adenine permease AdeP
Sequence:
MAMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVVFGLIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRKLVDVPPPEVVHQEP
Protein: Messenger RNA-binding inhibitor of apoptosis 1 (Q93367)
Organism: Caenorhabditis elegans
Function: RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline. Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:30728462}.
Interaction partners:
- K Homology domain-containing protein
- KH domain-containing protein
- Ankyrin repeat and KH domain-containing protein mask-1
- K Homology domain-containing protein
- K Homology domain-containing protein
Sequence:
MDDSTPYPVPQELYIPQKMKAFMAEPQGCALVAALEGQFQCSIVVINDHLSVISSADGVAVDINQIEKILRDVWRKRDVQIMIREAALNASCTHICHTLLPRAYCAVVLFFSSDLQRRSRCTDIIIDQFTGKVTMFGTEQAVNKAREMMIECLTEHFGLLEMNIPPTQRTTRMGYTNSYNPEIRTHLPPNSFLNSVFPMGEPNAILTSTPPTTSIMDEPLLSASLEKHLLFPSDFSVPPPRLSPVQELPLTPPKTCVVEKIKQWIPTTEVGKILGNRAAVKKHIERQFNCVITVHTEVQSSFGATPVEIVAQNKEQCQEARNAVMSLMQSHQDKPASNPPDSGFSTPGSPFTSDSSSTTPEKRGNSRQYHRGSFRDQPKVMLALTPRKLSPSD
Protein: N-acetyltransferase subunit Nat1, putative (Q38B37)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- N-acetyltransferase, putative
- N-acetyltransferase subunit ARD1
Sequence:
MATTLPLQQQRLFDKLARDFDAREYAKGLRTADSILSVVPNHADTLALKGLTLHHMGRKEEGREIIESALGFNDTSTVVWHSLGMCHRADDNHVEALHAFQKAHEYGPSNVNVLRDISSICVQLREWEQFVDVRRKMVTLRPGVRANWIALSCGHRMLGNKELAAAVIDVMTTIMEAGDNRAEKSEVRLYQVELELACNAPARALDLLKKHSQEIIDEYEKASLRAKTHALLGQKVEAEKWYMELITRGMAEADCVAAIAQLRKIPLDAARRPKRDVDKYLELLKQVQEVNPKSNYAKRQVLECVPIEQFRDQLREYAGMFIVKTIPSLFSVLKSLYQCPDRTQHIGEVFHQWEEELMAGDFSSFGGKKDPTFILWVWMYLASHYCRIREFGRALEYIGRAIDHTPTFDLLYLMKAKIQAKNNQLDEAAKTADMARRLDLQDKYLNGKAAKYFFRANKIREGEALMQMFYKTTEVPDDTYLTALESQCAWYEREVGDAYYRMGDYISALSNYLMCESHHQRNHNELSEFHNYVFRRCTMRAWFNVIACDDNLEENKFFQKLCPRIVRTYMKIHEEGEEAVRAKYAPRPEVGKYSDVEEGKRIANLRRTFYLHNVDISDPLKKAGRYLQASLLHNALSSEVHLLAVEFYTMCRMPFLVARELLILAKLKCPSTNELVTQFENNLFREMASSMDPRVESIIKETLTTALEKLN