wanglab/gogpt-training-data huggingface dataset:
Protein: Low-affinity potassium transport protein (P28584)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This protein is required for low-affinity potassium transport.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Outward-rectifier potassium channel TOK1 channel YORK)
- Na
- High-affinity potassium transport protein
- Serine/threonine-protein phosphatase PP-Z1
- Serine/threonine-protein kinase HAL4/SAT4
- Sodium/potassium exporting P-type ATPase 1
- Serine/threonine-protein kinase HAL5
- Low affinity K
- K
- Pheromone-regulated membrane protein 6
Sequence:
MPTAKRTSSRASLALPFQLRLVHKKSWGHRLRDFISGFLKSCRPIAKYVFPNFIVVHYIYLITLSIIGSILLYPCKNTAFIDVLFLAAGASTQGGLATKSTNDFNLYQQIVVYVITLLSTPILIHGFLAFVRLYWFERYFDNIRDISKQNFKLRRTMTLQQRELSGSSGNAARSRSFKDNLFRGKFVSREDPRQSASDVPMDSPDTSALSSISPLNVSSSKEESSDTQSSPPNFSSKRQPSDVDPRDIYKSIMMLQKQQEKSNANSTDSFSSETNGPAFIVQERHERRAPHCSLKRHSVLPSSQELNKLAQTKSFQKLLGLRRDEGDHDYFDGAPHKYMVTKKKKISRTQSCNIPTYTASPSPKTSGQVVENHRNLAKSAPSSFVDEEMSFSPQESLNLQFQAHPPKPKRREGDIGHPFTRTMSTNYLSWQPTFGRNSVFIGLTKQQKEELGGVEYRALRLLCCILMVYYIGFNILAFVTIVPWACTRHHYSEIIRRNGVSPTWWGFFTAMSAFSNLGLSLTADSMVSFDTAPYPLIFMMFFIIIGNTGFPIMLRFIIWIMFKTSRDLSQFKESLGFLLDHPRRCFTLLFPSGPTWWLFTTLVVLNATDWILFIILDFNSAVVRQVAKGYRALMGLFQSVCTRTAGFNVVDLSKLHPSIQVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYDSGQDDENITHEDDIKETDHDGESEERDTVSTKSKPKKQSPKSFVGAHLRRQLSFDLWYLFLGLFIICICEGRKIEDVNKPDFNVFAILFEVVSAYGTVGLSLGYPNTNTSLSAQFTVLSKLVIIAMLIRGRNRGLPYTLDRAIMLPSDKLEQIDRLQDMKAKGKLLAKVGEDPMTTYVKKRSHKLKKIATKFWGKH
Protein: Homeobox protein (Q24416)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MILKLIFCIADPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKMSANQSFLKNVNDLTILKTRPVSRSQSLAPQPPTSPPATPALRTHAEHRIG
Protein: UPF0612 protein C569.003 (Q9Y7S2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Phosphoribosylglycinamide formyltransferase
- Ribosome biogenesis protein nsa2
- Pumilio homology domain family member 6
Sequence:
MTSNENFENGFDLPPPDDSAEDLKLFIKKFERSLNSALLEFDENNQETIENFRQAKEHKMRFETECDQKLRNWKRLAIEREVSEEQSGEVQFPRWIDEWANTKLGGIFERIFSKMDSMQNDMNSRFDAMQTEMSVMKNGIASIKGEMAEMKGEMTVMKNDIASIKGEMAEMKGEMAVMKNDIASIKGEMAEMKGEMTVMKNDIASIKGEMAEMKGEMTIMKSDIDSVKGETTTLKGEVTAMKDSISQLDRKIDLLDQRTEERFNNMAQTMQKIDDRSCKSMMLTRKYENMVRSDMHYSAVPVPFLNGDEPRDYELPPLASFEDIDNLTKEQCIQYLHGYGVNKFSPLETVKLKERLQEAIGLWSKGHESHKYHTF
Protein: WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) (O75717)
Organism: Homo sapiens (Human)
Function: Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.
Subcellular location: Nucleus, nucleoplasm {ECO:0000305|PubMed:34694004, ECO:0000305|PubMed:35585232}.
Interaction partners:
- TIMELESS-interacting protein
- Cell division control protein 45 homolog
- DNA replication licensing factor MCM3
- Protein timeless homolog
- DNA replication licensing factor MCM5
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
- Claspin
Sequence:
MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
Protein: 14-3-3-like protein GF14 nu (General regulatory factor 7) (Q96300)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P48349}. Cytoplasm {ECO:0000250|UniProtKB:P48349}. Note=Translocates from the cytosol to the nucleus when phosphorylated. {ECO:0000250|UniProtKB:P48349}.
Interaction partners:
- Alba DNA/RNA-binding protein
- Dual specificity phosphatase Cdc25
Sequence:
MSSSREENVYLAKLAEQAERYEEMVEFMEKVAKTVDTDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVSIIKDYRGKIETELSKICDGILNLLDSHLVPTASLAESKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLVAYKSAQDIALADLAPTHPIRLGLALNFSVFYYEILNSPDRACSLAKQAFDEAISELDTLGEESYKDSTLIMQLLRDNLTLWNSDINDEAGGDEIKEASKHEPEEGKPAETGQ
Protein: FAD-dependent monooxygenase dbaH (EC 1.-.-.-) (Derivative of benzaldehyde biosynthesis cluster protein H) (Q5AUX8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E and F have still to be determined (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MPGTVRPGEPVQVAIIGGGIVGVVLAVGLIRQNVKVRLFEQSQGFREIGAGIAFTANAIRCMEQIDPAIVTALRSSGSVPTSTGDEKDPNDYLRWIDGYNLHREDDPYYQRMLYKINAGYRGFEGCRRDQFLEALVKVIPPEVVECKKRLESIEERGLEEKLILTFVDGTTVEVDAVIGCDGIKSRVREIILGEGNPASYPHYTHKVAYRTLIPMEDAIKALGEYKAKNQHNHVGPNAHLIHYPVANKKMINATAFVSDPNEWPNDRQMVAPGCREDMEKAFAGWSPCVRNVVNLFPKELDKWAVFDLWDYPAPFYNKGKICLAGDAAHASSPHHGAGACIGIEDALCLATLMKQVNVSVQASRVSKGKALSAAFETFNAIRRTRSQWLVNSSRRVCDFYHQPEWADPAKWVKAETCFEELKDRSYKIWHFDYDEMIKETLKSYSNREAALLQESSEGSVEK
Protein: Protein sister of odd and bowel (Q9VQS7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions (By similarity). May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Segmentation protein even-skipped
- Segmentation protein paired
- Segmentation protein fushi tarazu
Sequence:
MEAVKHLSAAAAAAAAAATCSDSPAKAAASPAASSDIAEALGELKASATAAASSASKAATSKHHSNNNHKPSAAATATAAHKKSESCNSNGNKCTAATSPIGSKTSNAAMAAATATAAAATNDLAAAAAVVLSLQGTMVSSLQQAALLPANSAAAAALNLQALESYLALQRLTGKSDVFRFSNSNTGSSNSNNATTCNSSSSEADNNALPSLIDIANIELKSSCSSSSSGEPPLTAATASAAATSSPSSNNSNSTSTPTTSKCVPLPSIGTVSAAVAAAAAAAAAAASQQAALDCATAAELAAECDLPLLDGEDALSFEAGDLDSSYGSFMFNPSAFSQAETDSALHSLQATMYQDKMSVISGAAGGVGAGAVGGLEEAGSSAAAAAAQRSKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCAECGKGFCQSRTLAVHKILHMEESPHKCPVCNRSFNQRSNLKTHLLTHTDIKPYNCASCGKVFRRNCDLRRHSLTHNLSAGVGGVVGGNLSDPFGSGSSSSSELGLPTGSASTAASSRDLVAVSD
Protein: mRNA cleavage and polyadenylation specificity factor complex subunit pta1 (Q10222)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- mRNA 3'-end-processing protein yth1
- Endoribonuclease ysh1
- Poly
- Cleavage factor two protein 2
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- Protein cft1
- Polyadenylation factor subunit 2
- Pre-mRNA polyadenylation factor fip1
- Uncharacterized WD repeat-containing protein C824.04
- mRNA 3'-end-processing protein rna14
Sequence:
MEVSETDEHLTRLNQARDIVKTDQSLFPEIVRNILSVANYSDIRYKKWMANFLWFGFSSKNVKFEQKLDLAVTCLDTIVSLYAVDNEEVKKDVISCSCTIYPLVFLHCCTSPNDSSTWDTLTKLKNEIINDFDKGNKPLLISCIKFISCVILTQVPGIRDPRLVTKSDVSLSKVPTHHPFINSNILRIEANDLIEKIFSILFSDSLNVLYITSVLNILPVLVKRRKELAPKIIGSLLEFHLPNPKDEIELSNESKLAIRCIEKNLKLILLHLAKSTGASSSSVEKIHAYLSGQIYHTKVDESLKKRQYEGNISAASKRVKSSAVQSLVERMQPQLSSHDGLQNNPLISIFASQTAINPLANFDVTSIPVEVATEIVLTSLLKIDKNYFHQQINMLRERVRSLSEPESLGLDQQVDEDEDEDYEPPEVDVQTINASVEREAARLEGSAPSNVVTDAFELPTPDSLSPMAILEYFHGALSRLFDYAPQFERSIVSSSNLQNLTLENVDNTVWDKRHWAILLPRLCTRGLLNYQPVTSGEESGDASFTLSSFVRGQLFTYVASNWRSSTNLILNWLSEEWYNDRLMLENPDCHEYEDVKWEGPQYEKWALKVIDSILPYLEAKDKVFMIFMSELPELTDAIVDKIKFVCLDPDKTKLGFMTFQYLIMFRLTCT
Protein: Always early (Q2PNQ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRVKPGVASKRTENFTKKPSKISVDVSEDEKAKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGKSFEGIVNGTVMGYDPQDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLRILHDYLVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNGKLGRENSSNLETIIADLVTHMVDNIQPSLGRKLKDGVDSLEPLRQQVVQIFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS
Protein: Mitochondrial MYO2 receptor-related protein 1 (Q06324)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the guiding of mitochondrial tubules to the bud tip during cell division.
Subcellular location: Bud tip. Bud neck. Mitochondrion outer membrane; Peripheral membrane protein.
Interaction partners:
- Myosin-2
- GTP-binding protein YPT11
- GTP-binding protein YPT32/YPT11
- Nuclear migration protein NUM1
- Mitochondrial F-box protein MFB1
- Mitochondrial Rho GTPase 1
- vacuole-related protein 17
- Inheritance of peroxisomes protein 2
- Mitochondrial distribution and morphology protein 36
- Myosin-4
Sequence:
MNSPTMKSEQLTPKLSPMSFCLDDQRNAGSFQNLLNSPTKLKLDTGPIGNSLLYPTSLSKLSELSRGGRSKQRRGSDTMRSVSPIRFQFLNNTPKMLKPEYLSQTTSNLPLLSALLKNSKKTTSEGQNSNPDPLNIEKNIIKQSIKDKLEQLRSSESVAQVQKKERNPPSFEAKVCAEEPILRKNAEGLLPSYVPVPATPLEDPENHGVRKVEDKGLRVVSGGSTQCLSTEVNELPKDLNLDNLPTDNNGFVQYGLKGNNNNNRYSFISSTSTDYEPEWCDGQQHISMQMASMANAEEANSREKSNLDIKIKQLELEITELKLQNEKLVHSMTTNRYIEERFMLEVMKDPSIQAQRSQRDIERKVKQLEKKFFNCKKVLKKLTESSAVVATSTSKTEGNSARIPCPKTRLARVSVLDLKKIEEQPDSSSGTSSEEDHLTNDDTDANTSEDLNVAFEEEPTSAISTTASVQSGESKRGFQLNLPVQVEKKEK
Protein: Dendrin (Q80TS7)
Organism: Mus musculus (Mouse)
Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein.
Subcellular location: Cell projection, dendritic spine membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Perikaryon {ECO:0000250}. Nucleus. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.
Interaction partners:
- Protein KIBRA
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Synaptopodin
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Sequence:
MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQSMDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPEPRNALRAAQPTGFPVFSRPERFGQVGRAPRPSVLPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARARPESCKGAIEKSSGLVAAGLNSAGDSHSQGKTTGGPGTDAALSRSAISSPPRPVPRSRQHLRGSRKGKEGSEQIWLPTCWLASPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGAEHETLEVWKVTRRAHTLPRISRGPAGREGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPCHEEEGEGAAANPSVCQKRLLSSRVLNQPSEGRECEAEVGQQGDSSLEERSSSGLGFPVGEVNPRDAPTQPGSQEHPTLGPAAPVCAGSLKGSEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSVHSGSSDGSDTDAPGASWRNERTLPALGNTRPREGGKTAGLSDSIREIVDVISQTEEGFIREDTRKTPQGNRERE
Protein: Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) (Q6TGS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P54577}. Nucleus {ECO:0000250|UniProtKB:P54577}.
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Methionyl-tRNA synthetase
- Alanine--tRNA ligase
- Tryptophanyl-tRNA synthetase.
- Glycyl-tRNA synthetase.
- Lysine--tRNA ligase
- Isoleucyl-tRNA synthetase
- Serine--tRNA ligase, cytoplasmic
- Tyrosine--tRNA ligase
- Glutaminyl-tRNA synthetase
Sequence:
MGEQLSPDEKFQLITRNLQEVLGEERLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVKYYEQVIKAMLESIGVPLDKLKFVKGTDYQLSREYTLDVYRLSSMVTEHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTLAEKYLPSLGYTKRSHLMNPMVPGLTGSKMSSSEEESKIDLLDKNQDVKKKLKKAFCEPGNVENNGVLSFVKHVLFPLHSEFVIKRDPKFGGDKVYTDFEEVEKDFAAEQIHPGDLKASVELALNKLLDPIRKKFESPELKKLTSSAYPEPSKNKGGVKGNPKQTTDDDEVIPSRLDIRVGKVISVEKHPDADSLYLEKIDVGEEQPRTVVSGLVAYITEEQLQDRLVVLLCNLKPQKMRGIESQAMVLCASIEGEPRKVEPLDPPEGSAAGDRVYVEGYESGKPDDELKPKKKVFEKLQVDLKISGEFVAQWKEQNLMTKLGRITCKTLKGGNIS
Protein: Bromo domain-containing protein (Q383S2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVLTGVKLAEDINYWIRYIDCALSHPLPLPKNKHVFHSDQRLAPEIRDLYDCLYKLYAEESASEYFREPVDALRVGAWNYYSVITEPMSLRTVLDYIVQGGRYSQVEQIMNDVELIWKNCERYNGAESHLAADARRCRAILEKHRERLADEQTAPAAEVDELIEALESMDDSVLKAVEAYFLREDPTLILSSGDVDIPSLRVKHLRAMKEIVQRAANGQLE
Protein: Dopamine beta-hydroxylase (EC 1.14.17.1) (H0Z5G7)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000256|ARBA:ARBA00004553}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000256|ARBA:ARBA00004351}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004351}.
Interaction partners:
- Phenylethanolamine N-methyltransferase
- Aromatic-L-amino-acid decarboxylase
- catechol O-methyltransferase
- Amine oxidase
- Uncharacterized protein.
- Amine oxidase
- Amine oxidase
- Tyrosine 3-monooxygenase
Sequence:
MQSSRSKPCSCPSLKLREVASMYFTMVAAFLVILVVALQGSAPRQSDFPYKVPLDPQGLLELSWNVSYPEQAVHFQLLIRELHFGLLFGMSDRGEFENADLAVLWSDGHNSYFGDAWSDAKGQLHMDSQQDYQLLGARRAPEGLYLLFRRAFSTCDPKDYLIEDGTVHLIYGILEKPVRSLQAINISALHGGLQRVQLLKPNISIPQLPRDMKTMEITAPDVVIPSQETTYWCYMAELPEGFPKHHIIMYEPVVTAGNEALVHHMEVFQCAAHFDSFPLYNGPCDSKMKPERLNYCRHVLAAWAMGAQAFYYPEEAGLAFGGPGSSRYLRLEIHYHNPLVFTGRRDSSGIRLYYTATLRPYDAGIMELGLVYTPVMAIPPGEDSFILTGYCTDKCTQLALPAAGIRIFASQLHTHLAGRKVVTVLARDGRERQVVNADGHYSPHFQVLGLQGARLGDELITTCTYNTEDRSRATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGYLHRYFNLVNRFNDEEICMCPQVSVPQQFYSIPWNTFNRDVLKSLYGFAPISMHCNKSSAVRFPVGTASFPKLPCRIPRCKVGSVLLRTHPNPAGSGQEAGAAWKSLASAGHGAQPSPVLRQYIRSPPWMLPARSN
Protein: Cbx3 protein (Chromobox 3) (Q5RJL1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTELTSPGALPGALTLSE
Protein: Uncharacterized protein (Q57Y18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTAVKEPRVDFELHNSSIARDDACLQWFFSRYRAHTSTTLPSRSDTSAAPTTKGNDNIKNATEALLVQLENDVTACKALRWEKFRYSSPIYEAASPTYPLRRGSTIETVVEEVEDSAATTGTVGKPHRVLRVKLQESSPKHAHEARVRSVQEEPSRHVFAEMLRKKNRENLVRSIEEAEAARGHNGHSGWLRPYFGGYFHMPLPRGPTRFLVFPQWHHDVTVATEKQQWFPYFLRGSCYQKVPHARVPIVGDAVGPLRMPWNDLVLAVSFAREFPRELSEDFGDRVRLWRDVDAIYLDGHANQVRTERLVLCKTRSKSPEMNHLSAGETAVVGMTEEAEAEGKETETEIITAKLRESGFRASLQFRNPRYSLTVKGTTCIPERAPNQRITSLLVLDEYDSFVQHFTSPFLRWLFPRATYCLRWAGGPGVDFNSAERSLTFFGKLWSEWWVELPLRADRFFLRLRNKSSLVQPLTAGQWKQTFSDVQVNGSHGSHAVRSGEHSLFWATQGPVWDAGLIRGFRDIYPGMHYASRWYTVLSMELGFGGKLRDESKMLVDGASQTGWRKPGGMIYANACLMDSFKNPPRASMGFSLTSRPRAREDAFNTLAPSSFECSFNWWLKFGRDGMKLLSGLVEGQSVDKAVLRPSATEAFHHLRCGLTWNL
Protein: CRS2-associated factor 1, mitochondrial (Q8VYD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the splicing of group IIB introns in mitochondria.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g06710
- RNA-binding KH domain-containing protein
- Pentatricopeptide repeat-containing protein At1g06270
- Protein WHAT'S THIS FACTOR 9
- DNA repair RAD52-like protein 1, mitochondrial
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- Nuclear intron maturase 1, mitochondrial
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- Cyclin-dependent protein kinase inhibitor SMR12
- Splicing factor-like protein 1
Sequence:
MFLIRLSRHNPSSFTLLTRRLHDQTISSSRLRDLYNFQSPPPLSSSASENPDFNQKNNNKKKPKPQYRPPSSLEGVKTVHSDLPFDFRFSYTESCSNVRPIGLREPKYSPFGPDRLDREWTGVCAPAVNPKVESVDGVEDPKLEEKRRKVREKIQGASLTEAERKFLVELCQRNKTKRQVNLGRDGLTHNMLNDVYNHWKHAEAVRVKCLGVPTLDMKNVIFHLEDKTFGQVVSKHSGTLVLYRGRNYDPKKRPKIPLMLWKPHEPVYPRLIKTTIDGLSIDETKAMRKKGLAVPALTKLAKNGYYGSLVPMVRDAFLVSELVRIDCLGLERKDYKKIGAKLRDLVPCILVTFDKEQVVIWRGKDYKPPKEDDEYSSFIHRESSIDSDVDLSCSRGAQDSPDETT
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q59DP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}.
Interaction partners:
- Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
- P-type Ca
- Nitric oxide synthase
- Troponin I
Sequence:
MATIDGRPAQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSDKKPRAGQILWIRGLTRLQTQLRVIRAFRSTLEDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQLNVSSGMMSPDISYIDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQSFSKIAQTLQQKIRGNIETKHSNGQNETRI
Protein: NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) (Q9H0M0)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34404733}. Cell membrane {ECO:0000269|PubMed:34404733}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BZZ3}. Nucleus {ECO:0000250|UniProtKB:Q8BZZ3}. Cell junction {ECO:0000269|PubMed:34404733}. Note=Translocates to the plasma membrane in response to increased cell-cell contact inhibition and subsequent interaction with the Crumbs complex. {ECO:0000269|PubMed:34404733}.
Interaction partners:
- Polyubiquitin-C
- Transcription factor HIVEP3
- Ubiquitin-ribosomal protein eL40 fusion protein
- Mothers against decapentaplegic homolog 7
- Polyubiquitin-B
- Spartin
- E3 ubiquitin-protein ligase Itchy homolog
- Receptor tyrosine-protein kinase erbB-4
- Ubiquitin-conjugating enzyme E2 L5
- Krueppel-like factor 5
Sequence:
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
Protein: Transcription factor E2F4 (E2F-4) (Q6DE14)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes. Component of the EDM complex, a complex specifically required for multiciliate cell differentiation: the EDM complex binds and activate genes required for centriole biogenesis. Activates genes required for centriole assembly (plk4, cep152) and genes specifically required for motile cilia formation (foxj1). Also promotes the deuterosome pathway of centriole biogenesis by activating expression of deup1, but not its paralog cep63.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q16254}.
Interaction partners:
Sequence:
MADPAQLTVTPSRHEKSLGLLTSKFVSLLQEAEDGVLDLKAAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIDLKAELADLEQREQELDQQRVWVQQSIKNVTDDVQNTGLAYLNHEDICRCFRGDTLLAIRAPSGTCLEVPVPENTNGQKKFQIHLKSTTGPIEVLLVNKDTSSSAPVVVPVPPPEDLIQAPPAVPSTPQRPALTPQNDIATSPAPTVPHSTISNAESQDCPTGQTFSMENTTSSRLPSIDTCPLQSSASLDNSNDSPDPSTSFQPIKSDLSDVLELPKDMISDFFDQTKECITSDLLEELMSSEVFAPLLRLSPPPGDHDYVYNLDESEGVCDLFDVPINL