wanglab/gogpt-training-data huggingface dataset:
Protein: Centriolar and ciliogenesis-associated protein hyls-1 (Hydrolethalus syndrome protein 1 homolog) (Q95X94)
Organism: Caenorhabditis elegans
Function: Plays an important role in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19656802}. Cell projection, cilium {ECO:0000269|PubMed:19656802}. Note=Colocalizes with sas-4 to centrioles throughout the embryonic cell cycle and in sperm (PubMed:19656802). Localizes at the base of mature cilia (PubMed:19656802). {ECO:0000269|PubMed:19656802}.
Interaction partners:
- Spindle assembly abnormal protein 4
- Fas-binding factor 1 C-terminal domain-containing protein
- CEntrosomal Protein
- Fem-3 mRNA-binding factor 1
- B9 domain-containing protein 2
- Cilia- and flagella-associated protein 157
- Spindle assembly abnormal protein 6
- RFX-like transcription factor daf-19
Sequence:
MANFTTENELEDILHQMGHHIHDKNQFATFKNEIDNLLDRELCLSDADEDVMNESLFASLSVDPAAQFIRQERNFPTENLNIQSPIVSRKRQGKRFIYENVELQSDFDDESSNEYPERNLLVDRAWRSIHRAMETCNGATETLKSISLDGSDIQERSSVDDEENIAESVSVGLSTETEQSELQKSSRPEKEVWTRNVLSLEPGRAPKKYDPVTRYHFYKSEWDRHPAPGEMRRLSLRWKVREFMLRHDVPRLNENNEDWKANHDKDWSPRPYID
Protein: Mitochondrial fission 1 protein (FIS1 homolog) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) (Q9CQ92)
Organism: Mus musculus (Mouse)
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y3D6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3D6}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9Y3D6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3D6}.
Interaction partners:
- Dynamin-1-like protein
- TBC1 domain family member 15
- B-cell receptor-associated protein 31
- TBC1 domain family member 17
- Mitochondrial fission factor
- Dynamin-1
- Mitofusin-2
- Mitofusin-1
- Dynamin-like GTPase OPA1, mitochondrial
- Mitochondrial dynamics protein MID49
Sequence:
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
Protein: Ribosomal protein L30/L7 family protein (F4IT48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MYVGEMAESKVVVPESVLKKIKRQEEWALAKKDEAVAAKKKSVEARKLIFKRAEQYAKEYAEKDNELIRLKREAKLKGGFYVDPEAKLLFIIRIRGINAIDPKTKKILQLLRLRQIFNGVFLKVNKATVNMLRRVEPYVTYGYPNLKSVKELIYKRGYGKLNHQRIALTDNSIVDQALGKHGIICVEDLIHEIMTVGPHFKEANNFLWPFQLKAPLGGLKKKRNHYVEGGDAGNRENFINELVRRMN
Protein: Tubulin alpha-6 chain (EC 3.6.5.-) (P29511)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Gamma-tubulin complex component 4
- Tubulin beta-4 chain
- Tubulin beta-5 chain
- Tubulin beta-6 chain
- Tubulin beta-8 chain
- Tubulin beta-7 chain
- Tubulin beta-9 chain
- Tubulin beta-2 chain
- Tubulin beta-1 chain
- Microtubule-associated protein RP/EB family member 1B
Sequence:
MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPGDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVSILLDNEAIYDICRRSLNIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAFHEQLSVAEITNSAFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVGTIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGGDDEDDEGEEY
Protein: Anti-sigma factor FoxR (Q9I115)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- ECF sigma factor FoxI
- Metal-pseudopaline receptor CntO
- ECF sigma factor, FemI
- Probable sigma-70 factor, ECF subfamily
- Metal-pseudopaline receptor CntO
- FpvI
- Probable sigma-70 factor, ECF subfamily
- Fe
- ECF sigma factor, VreI
- Sigma factor PvdS
Sequence:
MDGTRGRVDEAVVRQAIHWLVRLRSQPADDRLQRACAAWRAEHGEHERAWQQVSALNEELQGRFKALPGGVAYGTLDSSAQRLQRRQALKLLSLLVAGGAVAWVGRDSLPWQRLSADYSTATGERRSIELVDGTRLQLNTDSAVDVRYDAGQRLILLARGEIFLASGADTQSPTHRPLRVRTAQGLFEALGTRFNVRLQDAATCLSVSEGSVRIDAFGARPLQAPVAEAGQSYRIAADGVRRLERPQMDAVAWADGLIVTRDMRLADFLAEVARYRNGYLGCAAEVADLRLSGVYRLDDTDKLLQVLARTLPVRLQRHTRWWVRVVAA
Protein: AT13773p (SCPR-A) (Q8MRS1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAFTKVLQLILLAVVAISSAVDYCALPTCLDKHVACNNKGNFSENCPKDVREVKIEPHHKLILNLFNELRNNVAGGKIEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRSTERFAYAGQNNAVFQYSGAETEYTDAEIIKEQIENWFAERSNASPEILASFPEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNFATSNIVGQPVYTPGEKATTGCKNRYGAAYDYPNLCYAKEIYDNEKVIENTQTM
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (B7GT47)
Organism: Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Function: Acts as a chaperone.
Interaction partners:
Sequence:
MARAVGIDLGTTNSCIATLEGGEPTVIVNAEGARTTPSVVAFSKSGEILVGEVAKRQAVTNVDRTISSVKRHMGTDWTVDIDGKKWTPQEISAQILMKLKRDAEAYLGEPVTDAVITCPAYFNDAQRQATKDAGKIAGLNVLRIINEPTAAALAYGLEKGKEDERILVFDLGGGTFDVSLLEIGKDDDGFSTIQVQATNGDNHLGGDDWDQKIIDWLVSEVKNKYGVDLSKDKIALQRLKEAAEQAKKELSSSTSTSISMQYLAMTPDGTPVHLDETLTRAHFEEMTSDLLGRCRTPFNNVLHDAGISVSDIDHVVLVGGSTRMPAVKDLVKELTGGKEANQSVNPDEVVAVGAAVQSGVIKGDRKDVLLIDVTPLSLGIETKGGIMTKLIDRNTAIPTKRSEVFSTAEDNQPSVLIQVYQGEREFARDNKPLGTFELTGIAPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGKEQSMTITGGSGLPKDEIDRMVKEAEAHEAEDKQRKEDAETRNQAEAFAYSTEKLVNDNKDKLSDDIVKEVTDKVNALKEALKGDDTEKVKTAQTELMTAAQKIGQVLYAQQGAEGAAAGAGAAGAAGAGASAGSASGSDDDTVEAEVVDDDDDKDNK
Protein: Conserved hypothetical secreted protein (O25873)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
Sequence:
MKKALISTLFGVSLAFAKPYTIDKANSSVWFEVKHFTFNETRGAFDNFDGKIDLEPNTKMLSVFEGNIDVKSVNTRDRKRDNHLKTADFFDVVKYPKGSFKMTKYEDGKIYGDLTLRGVTKPVVLEAKIQAPLQNPMNKKEFMVLQAEGKINRKDFGIGKTFSDAVVGDEVKIELKLEAYAQ
Protein: Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) (Q1KMD3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q00PI9}.
Interaction partners:
- GTP:AMP phosphotransferase AK3, mitochondrial
- Heterogeneous nuclear ribonucleoprotein A0
- ELAV-like protein 2
Sequence:
MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQYWGQPGNRGGYRNFYDRYRGDYDRFYGRDYEYNRYRDYYRQYNRDWQSYYYHHPQDRDRYYRNYYGYQGYR
Protein: Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) (Q7Z628)
Organism: Homo sapiens (Human)
Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Transforming protein RhoA
- Rho-related GTP-binding protein RhoB
Sequence:
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
Protein: SEC24 homolog B, COPII coat complex component (F6YIN5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
ASQPYSSLGNRYSSPTTYSANASVASQGYPSTCSHYPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARPVKESYSGPSTALTYPSRPPPPPSQHQQQQQQQQQQQQQQQSHSGYSSLPWSGPALPPAQDSLIRNQMGSLATANSHPTNNENVQPPKSSSVVSTVLPGPSSTRMPPAPSHPVGPVPSAPPPPEQMQTKVRFPVPSLAGCGKWRPVNRDPGLWGACIGRMRERPPEKFANKGVDSSSTTSSASPLPNSYDALEGGSYPDMHSSSASSPVPDHALEPSPTLAQALSAAPTPPAAQPAKVAKPFGYGYPALQPAYQNAAPPPMPAAHPSGPAYTGYPQHYPGVNQLSSGLGGLSLQSSPQPESLRPVNLTQEKNILPPTPIWAPVPNLSAELSKLNCSP
Protein: rDNA transcriptional regulator POL5 (EC 2.7.7.7) (DNA polymerase V) (POL V) (DNA polymerase phi) (P39985)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays an important role in the regulation of rRNA transcription. Binds near or at the enhancer region of rRNA repeating units. May have DNA polymerase activity, but it is not required for in vivo function.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12093911, ECO:0000269|PubMed:14562095}.
Interaction partners:
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 9
- U3 small nucleolar RNA-associated protein 4
- NET1-associated nuclear protein 1
- DNA polymerase IV
- U3 small nucleolar RNA-associated protein 8
- rRNA biogenesis protein RRP5
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein 22
Sequence:
MTGKVNRDLFFKLASDLREERLHAAVALIKDLSALDLPDDAEEWSYVLNRLIKGLSSDRNSARLGFSLCLTEVINLAVNMPPGQRPKGLESTNEFLSTLSTILNVNVNEGTKKSMKGKDERGILFGKLFGLKSLLNEPLFSEIFVKDLEKGNTEFFIRFTEQLIDLALKKNWIKEPCFFTLFQTMKMLLPFMDESSAEKILLIYDKYDLTLTNEGLSTYLLLKYEGDESLIPSVLDLKNPGWKDNDPLARGNLPLLTKVLRNSSVIPDANGGLKETKKQKNTNWNPRLHFVWSVLLPLFGNGKLENTSHISKKRKKTNNKKVQNSIQFPEFWKMAVDESFFNEKASSERKYLGFLIIDAAFKAVPGSYIGFCFSQNVMRTLINQSIDSQRVLNKISQLTLDSIVKACEEDSANRLVPCLNAMLFGPHGSINFDKLTKSGTVSKLIAIKELPSTVLAQLLDVFFLQLQDKKGVLSHTLFALDSILHIVRAHKVEINDMDIMKPVLRPIVYMAFFKHTSDDLKLEQLHELAKERLYSILGELTINKEIRCKDPEINSWQYLTLKLILDIENSHVGDLINPLDENLENIKNEAISCLSKVCRSRTAQSWGLSTLLSMCLVQLYAGDTDSISVIEELCEFSKHENNSMVGITEILLSLLAQKKALLRKLSLIIWQQFIEEVGLEELQILLDILKARENKQGFAQLFEGEEEFEEIKEENDASEDESKTGSESESESESDSDDADEKDEEDEANEDILNIDKEATSALVKALNLPDNIVNDKGEVDLDQLEGLSDDGGDDEDEESMDDEKMMELDDQLSEIFKRRKEALSSISTGNQRKFEVKQSRENVISFKHRVVDMLAVYVKYCEKLTLANKSEHSNNLGGSLSKLVYFIIPMLKCVNETLDRPLADKISKLLKGKIFKIKVTAFKDMNKDIELMDLLKKTHKLMLTSKPGQHAAVFYSMCSTSSLFLSKLYVEIGGNDKLDELIDLYTATTKEWMQKGKCGPNIFIDFINWLSSKKQTVMDKE
Protein: S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (Alcohol dehydrogenase class-3) (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (P25437)
Organism: Escherichia coli (strain K12)
Function: Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1731906}.
Interaction partners:
- S-formylglutathione hydrolase FrmB
- S-formylglutathione hydrolase YeiG
- Transcriptional repressor FrmR
- Bifunctional aldehyde-alcohol dehydrogenase AdhE
- Probable alcohol dehydrogenase EutG
- Probable alcohol dehydrogenase
- Alcohol dehydrogenase, propanol-preferring
- Aldehyde reductase Ahr
- Aldehyde dehydrogenase B
- Aldehyde reductase YahK
Sequence:
MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHNTAKVQPGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAVAGQEISTRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY
Protein: Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190) (P97846)
Organism: Rattus norvegicus (Rat)
Function: Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, paranodal septate junction {ECO:0000269|PubMed:9396755}.
Interaction partners:
- Neurofascin
- Contactin-1
- Contactin-2
- Receptor-type tyrosine-protein phosphatase zeta
- Gliomedin
- Potassium voltage-gated channel subfamily A member 1
- Protein 4.1
- Myelin basic protein
- Neuronal cell adhesion molecule
- Cell adhesion molecule 4
Sequence:
MMSLRLFSILLAAVVSGAQGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQQGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSNILYFDGDDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDLSWHYVRVDRYGREANLTLDGYVHRFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVQRHSRITFEGNVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDQSCIDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSSSEAQFFLRPLRCYGDRNSWNTISFRTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFCQWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNLQSALRSAAQEFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDSHPGGKAPLPPSGPAQAPAPTPAPTQVPTPAPAPASGPGPRDQNLPQILEESRSE
Protein: Zinc finger CCCH domain-containing protein 8 (Fetal liver zinc finger protein 1) (Q9JJ48)
Organism: Mus musculus (Mouse)
Function: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene.
Subcellular location: Nucleus {ECO:0000269|PubMed:11318609}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). {ECO:0000250}.
Interaction partners:
- Little elongation complex subunit 1
- Little elongation complex subunit 2
- RNA polymerase II elongation factor ELL
- AF4/FMR2 family member 4
- Negative elongation factor B
- RNA polymerase II elongation factor ELL3
- RNA polymerase II elongation factor ELL2
- Negative elongation factor E
- Parafibromin
- Transcription elongation factor SPT5
Sequence:
MDFENLFSKPPNPALGKKPAADPEERIDEIDGTEVEETQTEKVKWKVKRDREQIPKKFKHLGNAATSPKSLLRKKSRSKDYDPYSDGETCSQGSEDNFDKELQQYIQAKEMANAAQPSLLPEESVKKAGAEGTQQTAKQKNKKSKAGHKKVKQKKMKRKWPGTGDKGSRALLKNSGSREQTDEPEEKQPRVRMSQGFINQHTVERKGKQVCKYFLERKCIKGDQCKFDHDAEIEKKKEMCKYYVQGYCTKGENCLYLHSEYPCKFYHTGTKCYQGDHCNFSHAPLTAETQELLAKVLDTDKKSCK
Protein: Klra21 protein (Q14B12)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQDVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVCSVPWQLIVIALGILCSLRLVIVAVFVTKIFQYSQHKQEIPETPNHHHNCSNMQSDIKLKEEMSTTESIDCRPSNELLEYIKREQERWNSESKTVLDSSRDTGRGVKYWFCYGTKCYYFIMNKTTWSGCKANCQHYSFPIVKIEDEDELKFLQRHVIPESYWIGLSYDKKKKEWAWIDNGPSKLDMKRKMNFTSRGCVFLSKARIEDTDCNTPYYCICGKKLDKFPD
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (Q381U4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKGAMPPRQPPVRPCVVPRASIARAFAAFAVSIVASYLVGTKMGPITVIITLALFLFGSFNLLRHALNLVVVNANEANYNNMLRRADLMQHPSNQKFSDCGENAWVSFGFSCMQGWRRAMEDDHVTLLTCDGGFFGVFDGHSGANVAKFCGGNIFGFISQTEAYKNGNYSRAIYDGFMTIDKHIYSNFKDEKSGCTAVVLFVKGDNLYCGNAGDSRSVLCSDGEPVPLSTDHKPFLPTEQTRIERAGGYVWNRRVNGALALSRAIGDFSFKSNTLVPWDQQAVTSAPEVHRTLLDRTRDEFAVVACDGIWDVLSNEQVVRFVRLRIQRQVPLDKIAEELLDHCLSPHPFGVGCDNMSVVIVKFKQSPPVSPEEEFNVPAADVAESPEQLPLLSPASDGGGRDFREENRRVGSNVTETNSLLVAEDGEES
Protein: Transcription factor unc-37 (Uncoordinated protein 37) (O02482)
Organism: Caenorhabditis elegans
Function: Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. In concert with unc-4, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate. May function with transcription factor mls-1 to promote uterine muscle specification and formation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein unc-4
- Protein pop-1
- STI1 domain-containing protein
- Helix-loop-helix protein lin-22
- T-box protein 12
- Homeobox protein engrailed-like ceh-16
- Histone deacetylase 1
- Runt-related transcription factor rnt-1
- C-terminal-binding protein 1
- T-box transcription factor mls-1
Sequence:
MKASYLETLDRIKDEHAEMSKHVNQQRSDIEKVALEKENMNRSYMTYAEVSNTLRSDLRKAEEINKRLQEFIMQSLAPQLSQDNQANCLAALEAFKTASPRENGNGAPALPPGFPPGAAGMLGMMPNMPFGMSPAMSQLFNQFASPHVNGGDGAGGSSGGASEAKKAKLEDPDDGELEIDVTNDDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQPLAGLQGLEQMNFLAGFNPNLLRQASAAGGFNFLNDPHAQARLAAAIGQIGSRPAYSFKIVDGGVPTPTSFPPDAQKGPGIPTGLKKKMELNHGEVVCAATISRDNSRVYTGGKGCVKIWDVKESDISGATVVNRPPIASLDCLKENYIRSCKLFEDGNTLLIGGEASTVALWDLTTETKTLDLETDSQACYALAMSPDEKLLFACLADGNILIYDIHNKVKVGTLPGHQDGASCLDLSKDGTKLWSGGLDNSVRCWDLAQRKEVAKHDFASQVFSLGCCPNDEWVAVGMENNYVEVLSTTGKEKYQLTQHESCVLSLKFAHSGKFFISTGKDNALNAWRTPYGASLFQLKENSSVLSCDISFDDSLIVTGSGEKKATLYAVEY
Protein: Suppressor of fused homolog (A9JRW8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}. Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
Interaction partners:
Sequence:
MDEMRPSSGAAAHLGLASIFPPGLQAIYGECRRLYPDQANPLQVTAIVKYWLGGPDPLDYISMYRNVGCPGQDVPEHWHYVSLGLSDLYGDNRVHEFTGLEGPSGFGFELTFRLKREAGETAPPTWPAELMQGLARYVFQSENTFCSGDHISWHSPLDNSESRIQHMLLTEDPQMHPVQTPFGHVSFLQIVGVCTEELQAAQQWNGQGILDLLRGVHIAGGPWLITDMRRGESIFDIDPHLQQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEDDSRSICIGAQPRRLSDKDTEQIREALRKGLEIKSKSILPPISGQRHSHDRPQSRKDSLESESSAAIVPHELVRTRQLESVHLKFNQESGTLIPMCLRGRLLHGRHFTFKSINGDTAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEQMLAEVQDLSTRDVCKLPKEYSWPDKKLKISVLPDTVFDSPLQ
Protein: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Q5XFW3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
EAWYPPGHGDIYASFYNSGLLDTFIEEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNPKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
Protein: Vitri peptide A (P83840)
Organism: Viola arvensis (European field pansy) (Field violet)
Function: Probably participates in a plant defense mechanism. Has strong cytotoxic activity against human lymphoma U-937 GTB and human myeloma RPMI-8226/s cell lines.
Interaction partners:
Sequence:
GIPCGESCVWIPCITSAIGCSCKSKVCYRN
Protein: Profilin (Pollen allergen Cro s 2) (allergen Cro s 2) (Q5EF31)
Organism: Crocus sativus (Saffron)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P35081}.
Interaction partners:
Sequence:
MSWQTYVDEHLMCDMDGHVLTSAAILGHDGSVWAQSAGFPELKPAEITAILNDFNEPGSLAPTGMYINGAKYMVIQGEPGVVIRGKKGSGGVTIKKSNMALIFGLYDEPMTPGQCNLVVERLGDYLIEQGY
Protein: Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) (Q01130)
Organism: Homo sapiens (Human)
Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Subcellular location: Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm.
Interaction partners:
- Serine/arginine-rich splicing factor 3
- Splicing factor U2AF 35 kDa subunit
- Transformer-2 protein homolog beta
- Serine/arginine-rich splicing factor 1
- Splicing factor U2AF 65 kDa subunit
- SRSF protein kinase 1
- U1 small nuclear ribonucleoprotein 70 kDa
- Serine/arginine-rich splicing factor 9
- Serine/arginine-rich splicing factor 4
- Serine/arginine-rich splicing factor 7
Sequence:
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS