wanglab/gogpt-training-data huggingface dataset:
Protein: Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (A0A2R8YFD1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
Sequence:
XFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDTISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Protein: DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36) (F5HC97)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Accessory subunit of the DNA polymerase that plays an essential role in viral DNA replication and acts by increasing the processivity of polymerization. Forms dimers that binds to double-stranded DNA and UL54 specifically to stimulates long chain DNA synthesis efficiently. Plays an important role in maintaining the structure of viral replication compartments by interacting with host nucleolin/NUC. In addition, suppresses innate immune responses through effects on host IRF3 and NF-kappa-B. Mechanistically, interfere with the binding of IRF3 and the p65 NF-kappa-B subunit to the promoters of antiviral genes, thereby inhibiting the expression of these genes.
Subcellular location: Virion {ECO:0000250|UniProtKB:P16790}. Host nucleus {ECO:0000250|UniProtKB:P16790}.
Interaction partners:
Sequence:
MDRKTRLSEPPTLALRLKPYKTAIQQLRSVIRALKENTTVTFLPTPSLILQTVRSHCVSKITFNSSCLYITDKSFQPKTINNSTPLLGNFMYLTSSKDLTKFYVQDISDLSAKISMCAPDFNMEFSSACVHGQDIVRESENSAVHVDLDFGVVADLLKWIGPHTRVKRNVKKAPCPTGTVQILVHAGPPAIKFILTNGSELEFTANNRVSFHGVKNMRINVQLKNFYQTLLNCAVTKLPCTLRIVTEHDTLLYVASRNGLFAVENFLTEEPFQRGDPFDKNYVGNSGKSRGGGGGSGSLSSLANAGGLHDDGPGLDNDIMNEPMGLGGLGGGGGGGGKKHDRGGGGGSGTRKMSSGGGGGDHDHGLSSKEKYEQHKITSYLTSKGGSGGGGGGGGGGLDRNSGNYFNDAKEESDSEDSVTFEFVPNTKKQKCG
Protein: Uridine kinase (EC 2.7.1.48) (Cytidine monophosphokinase) (Uridine monophosphokinase) (P67413)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00551}.
Interaction partners:
Sequence:
MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKDQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK
Protein: Protein GAMETE CELL DEFECTIVE 1, mitochondrial (OsGCD1) (Q8S2G4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Essential for fertility (male and female gametophyte functions and development). Required for the integrity of female gametic mitochondria (By similarity). Involved in embryo apical-basal patterning, and particularly dorsal-ventral patterning, during early embryogenesis, and endosperm free nucleus positioning and development as well as early endosperm development, probably by modulating the expression pattern of related genes (e.g. AL1, MYB3/AL2, CYP78A13/GE, PNH1, HAZ1, MPK6 and OSH1). Has function in triggering of endosperm programmed cell death (PCD) leading to syncytial endosperm cellularization and starchy endosperm cell maturation. Implicated in central vacuole dynamics necessary for microspore development leading to pollen production, and for pollen development and germination.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:28585692}.
Interaction partners:
- Os01g0220300 protein
- Large ribosomal subunit protein bL21m
- Os07g0658200 protein
- Ribosomal protein
- Large ribosomal subunit protein uL11m
- Os08g0513300 protein
- LSU ribosomal protein L15P
- Os03g0612600 protein
- Small ribosomal subunit protein uS3m
- Small ribosomal subunit protein bS18c
Sequence:
MLALRKTLLHGRLPAAPPAAAAAAIASRIPALLRRLSSSPGDGQGGDEWGSSWSTGITKEHFDGSDAAVGRPVTSPSKPVSPELAAVRAMDEEDEIFRAMERDNREAKAYVDSWGDRMRETCELLKQVREPGSRGSYLKDSEKQEMYRLHKEDPETYTVERLAKDFRVMRQRVHAILWLKEMEEEEERKLGKPLDDSVEVLLDSCPEFFNSHDREFHVASLPYKPDFKVMPEGWDGTTRDPDEVLYEISMKEDQMLYEEFVQRLQFNKKKVAGEVKCHKYSRRRPDDGWTYMVEKLGAQSKRGSGGGWKFASLPDGSSRPLNDMEKMYVKRETPKRRRRIMAPFK
Protein: Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) (Q14435)
Organism: Homo sapiens (Human)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC. Probably glycosylates fibronectin in vivo. Glycosylates FGF23.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack.
Interaction partners:
- Fibroblast growth factor 23
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Phosphate-regulating neutral endopeptidase PHEX
- C1GALT1-specific chaperone 1
- Klotho
- Beta-1,4 N-acetylgalactosaminyltransferase 1
- Mucin-1
Sequence:
MAHLKRLVKLHIKRHYHKKFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKNKMLDLMLEAVNNIKDAMPKMQIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDSNAPGASGKAFKTTNLSVEEQKEKERGEAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKLDEYVKQFSIVKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTPTFAGGLFSISKEYFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHSFPKGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKAFGDLSKRFEIKHRLQCKNFTWYLNNIYPEVYVPDLNPVISGYIKSVGQPLCLDVGENNQGGKPLIMYTCHGLGGNQYFEYSAQHEIRHNIQKELCLHAAQGLVQLKACTYKGHKTVVTGEQIWEIQKDQLLYNPFLKMCLSANGEHPSLVSCNPSDPLQKWILSQND
Protein: mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (A0A8I6A280)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGTEAGEGITFSVPPILSAGFCPIPEGGSCRRGGGAATAAEGEPSLQPLLMPPPPPPPGSFWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEALQSLREACEAVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKVCTGNYTFIPYMVTPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPTAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFNASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEEGDCEGDSLEYDYEHDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSTGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKTRAKSCGEKDGKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGPEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSRLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLDVDDEHEESPSNQTARRPQPVAEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKMETNRLLEELVRKEKELQALLHQAIEEKDQEIKHLRLKSQPIDTPGFPVCHLNAPGTAIEDSELTGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKGA
Protein: Candida glabrata strain CBS138 chromosome E complete sequence (Q6FVC8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Nucleoporin NSP1
- Candida glabrata strain CBS138 chromosome G complete sequence
- Protein DSE1
- Candida glabrata strain CBS138 chromosome D complete sequence
Sequence:
MLPFIQLLYLALYLTSDVLAMPLRKREIVTRVHTASTTNTVTNFFSTTTQVIIAPTVQVIISGDTTLFSTMVGEGGDINAEPTTTITSIIQVKRVSLANEQPTATSTTPMLDSSSSSATTTSSAISSDITTTSIPSSSSIPTTTPSSSSSSSSSSSSIQSSSIRFASQVVNLENVEANQNQQKQEEQQHVHNTAHISTPVVEMTTTTSSSSTTTLEPTASQSSTSNNNADTTIKSAPIAIAYSPYNNDGTCKSADQVKEDLQLIKSKGINQIRMYGTDCNSLQTVLPNAKSIGLSVNQGLWITSSGVDSIDIPLQQLINYGQTNGWDVFAYITVGNEAVISQYCSVSDLVSKIGQVRGQLKAAGYTGQLTTSEPPVTYEQHPELCTASGIDFVGINPHAYFDTYSSADTAGSFVKGQIELVQKACGTGNIVVTETGYPSAGIQNGGNIPSKPNQLIAIQKILEATNNQVTLLSCFNDFWKAPGPYGIEQYFGILDNLP
Protein: transketolase (EC 2.2.1.1) (C6KSV3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Glucose-6-phosphate isomerase
- Ribulose-phosphate 3-epimerase
- Ribose-5-phosphate isomerase
- Fructose-bisphosphate aldolase
- Glyceraldehyde-3-phosphate dehydrogenase
- Probable ATP-dependent 6-phosphofructokinase
- ribose-phosphate diphosphokinase
- Deoxyribose-phosphate aldolase, putative
- ribose-phosphate diphosphokinase
- Phosphoglucomutase, putative
Sequence:
MNIMDNEIDTKCINEIRMLSAELPLEAKSGHQGAPIGCAPIAHILWSYVMNYYNEDTKWINRDRFILSNGHASALLYTMLYLTEQGLSMEDLKSFRQFGSLTPGHPENHITKGVEVTTGPLGQGASNAVGMAIAAHNLADKYNTEEHKIFDNYVYAICGDGCMQEGVFCEAASLAGHLGLGRLILLYDDNKITIDGNTDLSFTENIEKKFEALNWEVRRVEDGNKDYKKILHEIEQGKKNLQQPTLIIVRTACGFGTKVEGTCKSHGLALNDEDLKNAKSFFGLDPQKKFHISDEVKEFYKNVIQKKKENYIKWKNMFDDFSLKYPQVSQEIIRRFQNDLPNNWKDALPKYTPKDAPGATRNLSGIVLNSINKIFPELIGGSADLSESNCTSLKEENDIKKNSYGNKYIRFGVREHGMVAITNGLYAYGGFKPYCGTFLNFYTYAFGALRLAALSNHHILCIATHDSVELGEDGPTHQPIEVLSLLRSTPNLNIIRPADGNEVSGAYLSHFSNPHTPTVIALCRNKVPHLNNTQPEQVLKGAYILEDFDTSNNPKVILTGSGSELHLCFEAKEILKNQHQLNVRIVSFPSWTLFKKQPEDYQYSVMMHNHPNLPRFYIEPASTHGFDTYFNVYIGINQFGYSAPKNKIWEHLGFTPENIVQKVLAFMKNKLK
Protein: Phenylalanine ammonia-lyase 1 (EC 4.3.1.24) (P24481)
Organism: Petroselinum crispum (Parsley) (Petroselinum hortense)
Function: This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MENGNGATTNGHVNGNGMDFCMKTEDPLYWGIAAEAMTGSHLDEVKKMVAEYRKPVVKLGGETLTISQVAAISARDGSGVTVELSEAARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGSDNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNQNITPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPTGVILSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSRFCEKDLLRVVDREYIFAYIDDPCSATYPLMQKLRQTLVEHALKNGDNERNLSTSIFQKIATFEDELKALLPKEVESARAALESGNPAIPNRIEECRSYPLYKFVRKELGTEYLTGEKVTSPGEEFEKVFIAMSKGEIIDPLLECLESWNGAPLPIC
Protein: Meiotic recombination protein rec12 (EC 5.6.2.2) (SPO11 protein homolog) (P40384)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotic recombination protein rec14
- Meiotic recombination protein rec6
- Meiotic recombination protein rec8
- Meiotic recombination protein dmc1
- Meiotic recombination protein rec7
- Linear element protein rec10
- Double-strand break repair protein rad32
- Meiotic recombination protein rec15
- Crossover junction endonuclease mus81
- Meiotic recombination protein rec11
Sequence:
MNSNDKKKVVRSWIEQFVHDFVEQLSKPTKDSVNVALKRRKHNSWNGSLDSKANERQKVKVFSFPRNETTIAQLFRVLDCVHEAVISDTVITKRDIYYRDVDLFKRQTVVDELLGDISNTIGCSRSDLNVEASAKGLVFGSIHIALENGTVITATKPLLISHHRISSITSTAKWVLVIEKEAVFQTLTEEALADTIIVTAKGFPDLMTRKFLVKLAKALPDAKFFGIFDWDPHGLCIYSCFKYGSNAYSHEPHSQLRNLQLLGPLYEDIFNKNQEFSLKLNKRDIKMITTLLQFEGFQKEPVVREQLQRMLFIQKKAEIQAILEFPSWIKGKLADADKSGKHSVR
Protein: Probable flagellar hook-length control protein (P23451)
Organism: Bacillus subtilis (strain 168)
Function: Controls the length of the flagellar hook.
Interaction partners:
- Flagellar FliJ protein
- Flagellar motor switch phosphatase FliY
- Flagellum-specific ATP synthase
- Flagellar motor switch protein FliG
- Flagellar motor switch protein FliM
- Flagellar M-ring protein
- FlaA locus uncharacterized protein YlxG
- Probable flagellar assembly protein FliH
- Flagellar protein FliL
- FlaA locus 22.9 kDa protein
Sequence:
MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSEQGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQMLQNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENEVSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQDLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLSKSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTLDLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTNENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLADEQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE
Protein: Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) (Q13490)
Organism: Homo sapiens (Human)
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
Subcellular location: Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Interaction partners:
- Tumor necrosis factor
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- TNF receptor-associated factor 2
- TNF receptor-associated factor 3
- Receptor-interacting serine/threonine-protein kinase 1
- TNF receptor-associated factor 1
- TNF receptor-associated factor 5
- Tumor necrosis factor receptor superfamily member 1A
- Diablo IAP-binding mitochondrial protein
- Caspase-9
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
Protein: Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) (Q6P9H4)
Organism: Homo sapiens (Human)
Function: Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22851176}. Apical cell membrane {ECO:0000269|PubMed:22851176}; Peripheral membrane protein {ECO:0000269|PubMed:22851176}.
Interaction partners:
- Interaction protein for cytohesin exchange factors 1
Sequence:
MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSPPYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEPSLLVSWFTRLKLLTH
Protein: Probable oxidoreductase (O53613)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable fatty acid synthase Fas
Sequence:
MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLAVRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIHFDDLQWERRYRRVAAYGQAKLANLLFTYELQRRLAPGGTTIAVASHPGVSNTEVVRNMPRPLVAVAAILAPLMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHDEQLQRRLWAVSEELTGVVYPVG
Protein: Uncharacterized protein C9E9.04 (O14290)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Dynamin-related protein dnm1
Sequence:
MTIYYMIVFMLLMVEIVSFVILSLPLPLKVRRAILNAISNSPFAGRVKHVLKITIICILILFADSVRRVVRVTKEYDLAIAAPSTTESARSGYKASQFYAQRNLYLCGSALFLSLVVNRYYLALEAMIAAQDKMQALQTQVEASTNNAKAVEELETLRTKLETRDKEYETLAEKYAAVTKTVEKKKDI
Protein: Probable transport accessory protein MmpS1 (P9WJT5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable transport protein MmpL1
- Conserved protein
- Possible conserved transmembrane protein
- Carboxyltransferase domain-containing protein
- Fluoride-specific ion channel FluC 1
- Probable conserved transmembrane protein
- Carboxyltransferase domain-containing protein
- Probable conserved membrane protein
- Probable conserved lipoprotein LpqU
Sequence:
MFGVAKRFWIPMVIVIVVAVAAVTVSRLHSVFGSHQHAPDTGNLDPIIAFYPKHVLYEVFGPPGTVASINYLDADAQPHEVVNAAVPWSFTIVTTLTAVVANVVARGDGASLGCRITVNEVIREERIVNAYHAHTSCLVKSA
Protein: Hap3p (A0A1D8PLA9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Hap5p
- Transcriptional activator HAP2
- Hap43p
Sequence:
MSRTNNKNPIDQNWQNNDYEIKEQDRFLPIANVGRVMKKALPEHAKLSKESKECIQECVSEFISFITSQAADRCLVEKRKTLNGEDILWAMYTLGFENYSETLKIYLAKYRQYEQEQLSLKPPRKKIRKRKTKSSLSQTQSKEQVDQDQDFQQIEQQYDDGEEEEEESENEEGDMSNIESNLILQNLPEYSDDYFDDEDEEEDRQQQREENSDNEPQQHHGDDSQPINLQPQLPSSAVPSLPTQQQQQFSDINPTTESNQQESFFTTQYYPNQTQYVNAAPLPTNPQPRQYQNQNQPNNYQNDQRQNDKQRIIPDLLNITNSYSEDEFI
Protein: Inner membrane permease YgbN (Q46892)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- 3-oxo-tetronate 4-phosphate decarboxylase
- 2-oxo-tetronate isomerase
- 3-oxo-tetronate kinase
- Uncharacterized HTH-type transcriptional regulator YgbI
- L-threonate dehydrogenase
Sequence:
MSTITLLCIALAGVIMLLLLVIKAKVQPFVALLLVSLLVALAAGIPAGEVGKVMIAGMGGVLGSVTIIIGLGAMLGRMIEHSGGAESLANYFSRKLGDKRTIAALTLAAFFLGIPVFFDVGFIILAPIIYGFAKVAKISPLKFGLPVAGIMLTVHVAVPPHPGPVAAAGLLHADIGWLTIIGIAISIPVGVVGYFAAKIINKRQYAMSVEVLEQMQLAPASEEGATKLSDKINPPGVALVTSLIVIPIAIIMAGTVSATLMPPSHPLLGTLQLIGSPMVALMIALVLAFWLLALRRGWSLQHTSDIMGSALPTAAVVILVTGAGGVFGKVLVESGVGKALANMLQMIDLPLLPAAFIISLALRASQGSATVAILTTGGLLSEAVMGLNPIQCVLVTLAACFGGLGASHINDSGFWIVTKYLGLSVADGLKTWTVLTTILGFTGFLITWCVWAVI
Protein: CaDmium Responsive (Cadmium-inducible lysosomal protein CDR-4) (G5EDZ7)
Organism: Caenorhabditis elegans
Interaction partners:
- ShKT domain-containing protein
- Nuclear hormone receptor family member nhr-115
Sequence:
MVCCCPVTTTLVVGAIAYFIYKKFFTPPTIKPKPAIHKTDYKKDTVYLYQFKRIKSCPNLSPFCMKLEILCRAYNIPYEVVETSMSRSRNGTLPFIELNGEHIADSDLIEIRLRQHFKIPSLPDEQEAQSVALSRMADNHLFYILIRYKSASDSLYNIFGDLFNLPSFLVPVVIPVVRAFFKRKIYYRCVGAIGDFEPQELDELLHRDLKVIQDSIKGNFLFGDKITPADATVFGQLATVYYPIRSHLTDVLDKDFPKVLEYLERVRKEIYPNDFTI
Protein: CUB domain-containing protein (LEV-10A protein) (G5EDX3)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein lev-9
- Immunoglobulin domain-containing protein oig-4
- Resistance to inhibitors of cholinesterase protein 3
- Acetylcholine receptor subunit alpha-type unc-63
- AcetylCholine Receptor
- Acetylcholine receptor subunit beta-type lev-1
- Protein unc-50
- Lipoma HMGIC fusion partner-like 3 protein
- Acetylcholine receptor subunit beta-type unc-29
- Uncharacterized protein
Sequence:
MHLIYLFLLSIFVSKADGNSRKTIFQCDQHFDESQPEGVIEFPSLPKQLALSHGVNNSKPEQQYNLQCVYTFVAGSRQRVRLEFDHFLLSGSSENCDIEYVDIYSEVESVDEDILSSALGGRYCGTVAPHVRISLRRVMKLVLHSRSTNHEDNHGFRAKYSFIPEDKFIAGEPVGGKKCSFIIDSSDRKIGTLYSPTYPGTYPHNMHCSYLMKAGRGERIRLFFTDFDIFFGGEHCPYDSVTIFDGPTPASPIIRKVCGLQQRMEVYSMGNSLLIHFNTTHPAKSDPRGFIMDYEFSTRFVNIDKLLNKQRGVTHIRGTECDVRVESNRETFHTISSPNYPEVYPANTTCTYIIHGLQGEQNLEKVILTFDSIAVLSFDTSPATAPPSADIDDIACPSAWVGIAIGEGNMKAVMSSTDDSTFDVTLCERIPPNSPLLGPYISEGPRMVMQFGSTETRDDNISPIGFKATIEFKTDFGVTGESLGTSNECKFRFTSSTGFFNSPRYPANYPLDTNCTYYIVGQPGKEILLHFEQFALSGNTDNNCNDYLDVYDVFVKNGKEELRRKERYCADTFPGPSVSAFGSHEMRVVFTSGSSGTANGFKALFEIRTARKEDVPRGEAHIRRGAYRCGSVINSTSEKPNGLIISPNYPVKYNKDVHCDWQINVKEGYQVLLKMEAIDVEGEMTSNGASCQKAVIRVDGGPRSEYCGTKREFFEAYLSPSNSVRISFLTAPDKVNGLKGFNLSWTEVKNLSGKDENVCKSDSLYLCTYSKLCIDAKLRCNGLDNCGYGVQDDTDEQHCSLKEKTGDRTVVIAAVFCGITFVLICIFFLYLFKKKLERKKKSKRKNDTKHRQRQPYRQQRPMHKQHCDSSELSPPATSRFVHHDATGMMPPIQLHQIGSSSRDMYA