wanglab/gogpt-training-data huggingface dataset:
Protein: Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) (P97839)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Disks large homolog 4
- SH3 and multiple ankyrin repeat domains protein 3
- Disks large homolog 3
- Disks large homolog 2
- SH3 and multiple ankyrin repeat domains protein 1
- SH3 and multiple ankyrin repeat domains protein 2
Sequence:
MKGLGDSRPRHLSDSLDPPHEPLFAGPDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPSHAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSMEGTTGKVGGNGGKKGVLEDGKGRRAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEGGAFRSGPASGLMTLGRQPERTQPRYFMHAYNTISGHMLKTTKNTTTELTAPPPPPAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRDMDSTAEGPIPCRRMRSGSYIKAMGDEDSDESGGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMPLPSKYPSWEEDYNPISDSLNDSGCISQVFGQASLIPQLFGHDQQVREADLSDQYEAACESACSEAESTAAEALDLSLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLPSSSCLVAYKKTPPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQSGLSNSSDSLDSSTRPPSVTRGGITPGPEAPEPPPKHAALKSEHGTLTSSESHSEAVPKRKLSSIGIQVDCIQPVPKEEPSPATKFQSIGVQVEDDWRSSAPSHSMSSRRDTDSDTQDANDSSCKSSERSLPDCTSHPNSISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWMETSSSSPAEPAQPGACRRDGYWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGICEQNLNPDANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVETPEKRKEEKKPPPPVPKKPAKSKAAVSRDKASDAGDKQRQEARKRLLAAKRAASVRQNSATESADSIEIYVPEAQTRL
Protein: G1/S-specific cyclin-E (DmCycE) (P54733)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:8187637}.
Interaction partners:
- Cyclin-dependent kinase 2
- Dacapo
- M-phase inducer phosphatase
- G2/mitotic-specific cyclin-A
- Transcription factor E2f1
- Retinoblastoma family protein
- Cyclin-dependent kinase 1
- RE32990p
- G2/mitotic-specific cyclin-B
- Cell division control protein
Sequence:
MGLNAKSVCSTSSTEPNGSIVTTAPSNGEVSSSIVVVVSSSSISSSSDSPIAILPHPDPIPSTSFSSASQRSEEELPGTSAASRTDEMCSCDSQNLAASTAATSNGNKRKRRLSSDSNEDPELGFEPPSAKRQQRLPALYGSEQGNLSSVASSVYTSPVVSVDGQSTQELLSIRSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTSTVVTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVIQPCARWMEPFFRVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARIQASPATALRAPESLLTPPASSHKPDEYLGDEGDETGARSGISSTTTCCNTAASNKGGKSSSNNSVTSCSSRSNP
Protein: Photosystem II assembly lipoprotein Ycf48 (P73069)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: A factor required for optimal assembly of photosystem II (PSII) which acts in the early stages of PSII assembly. Also plays a role in replacement of photodamaged D1 (psbA). May interact with precursor D1 to prevent its premature processing before association with D2 (psbD) (Probable). May also play a role in chlorophyll insertion into chlorophyll-binding proteins (Probable). Increasing levels of chlorophyll precursors partially suppresses deletion of this protein, supporting the idea that Ycf48 assists YidC in synthesis of chlorophyll-binding proteins.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01348, ECO:0000269|PubMed:18550538, ECO:0000269|PubMed:24681620, ECO:0000269|PubMed:33918522}; Lipid-anchor {ECO:0000269|PubMed:33918522}; Lumenal side {ECO:0000269|PubMed:30061392}. Note=Associated with a PSII precusor complex on the lumenal side of the thylakoid membrane. {ECO:0000255|HAMAP-Rule:MF_01348, ECO:0000269|PubMed:30061392}.
Interaction partners:
- Sll0933 protein
- Photosystem II lipoprotein Psb27
- Rubredoxin
- Photosystem II reaction center Psb28 protein
- Protein Thf1
- Photosystem II extrinsic protein O
- Membrane protein insertase YidC
- Slr1470 protein
- Cytochrome b559 subunit beta
- Photosystem II extrinsic protein U
Sequence:
MPVKFPSLKFEQLKQLVLVAAIAVFCVSCSHVPDLAFNPWQEIALETDSTFADIAFTEDPNHGWLVGTKETIFETTDGGDTWEQKLIDLGEEKASFSAVSFSGNEGWITGKPSILLHTTDGGQTWARIPLSEKLPGAPYSIIALGPQTAEMITDLGAIYKTTNGGKNWKALVEGAVGVARTIQRSTDGRYVAVSARGNFYSTWAPGQTEWTPHNRNSSRRLQTMGYGKDGQLWLLARGGQLQFSTDPDAEEWSDVIAPQDKGSWGLLDLSFRTPEEVWVAGASGNLLMSQDGGQTWAKDTGVEDIPANLYRVVFLSPEKGFVLGQDGILLKYNPSTEVAMVP
Protein: High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fc alpha/mu receptor) (CD antigen CD351) (Q8WWV6)
Organism: Homo sapiens (Human)
Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Immunoglobulin alpha Fc receptor
Sequence:
MPLFLILCLLQGSSFALPQKRPHPRWLWEGSLPSRTHLRAMGTLRPSSPLCWREESSFAAPNSLKGSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGSENNMLFLSMNLTISAGPASTLPTATPAAGELTMRSYGTASPVANRWTPGTTQTLGQGTAWDTVASTPGTSKTTASAEGRRTPGATRPAAPGTGSWAEGSVKAPAPIPESPPSKSRSMSNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPREDIEGVRIALDAAKKVLGTIGPPALVSETLAWEILPQATPVSKQQSQGSIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAASGEGSAAGDLDAATGDRGPQATLSQTPAVGPWGPPGKESSVKRTFPEDESSSRTLAPVSTMLALFMLMALVLLQRKLWRRRTSQEAERVTLIQMTHFLEVNPQADQLPHVERKMLQDDSLPAGASLTAPERNPGP
Protein: R-protein (Q84V54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEGFVSFGLQKLWDLLSRESERLQGIDEQLDGLKRQLRSLQSLLKDADAKKHGSDRVRNFLEDVKDLVFDAEDIIESYVLNKLRGEGKGVKKHVRRLARFLTDRHKVASDIEGITKRISEVIGEMQSFGIQQIIDGGRSLSLQERQREIRQTYPDSSESDLVGVEQSVKELVGHLVENDVHQVVSIAGMGGIGKTTLARQVFHHDLVRRHFDGFAWVCVSQQFTQKHVWQRILQELQPHDGDILQMDEYALQRKLFQLLEAGRYLVVLDDVWKKEDWDRIKAVFPRKRGWKMLLTSRNEGVGIHADPTCLTFRASILNPEESWKLCERIVFPRRDETEVRLDEEMEAMGKEMVTHCGGLPLAVKALGGLLANKHTVPEWKRVFDNIGSQIVGGSGLDDNSLNSVYRILSLSYEDLPTHLKHCFLYLAHFPEDSKIYRHGLFNYWAVEGIYDGSTIEDSGEYYLEELVRRNLVIADNKNLDWHSKYCQMHDMMREVCLPKAKEENFLQIIKDPTCTSTINAQSPSRSRRLSIHSGKAFHILGHRNNAKVRSLIVLRLKEEDYWIRSASVFHNLTLLRVLDLSWVKFEGGKLPCSIGGLIHLRYLSLCGAGVSHLPSTMRNLKLLLYLNLNVDNEELIHVPNVLKEMIELRYLSLPIKMDDKTKLELGDLVNLEFLFGFSTQHSSVTDLLHMTKLRYLAVSLSERCNFETLSSSLRELRNLETLNFLFTPQTYMVDHMGVFVLDHFIHLKELGLAVSMSKIPDQHQFPPHLVHIFLFYCGMEEDPMPILEKLLHLKSVELSNKAFAGRRMVCSKGGFTQLCALEISEQLELEEWIVEEGSMPCLRTLTIHDCKKLKELPDGLKYITSLKELKIEGMKREWKEKLVPGGEDYYKVQHIPDVQFINCDQ
Protein: Pancreas/duodenum homeobox protein 1 (Insulin promoter factor 1) (IPF-1) (Islet/duodenum homeobox 1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) (P52947)
Organism: Rattus norvegicus (Rat)
Function: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Hepatocyte nuclear factor 3-beta
- Insulin-2
- Insulin-1
- Neurogenin 3
- Forkhead box protein O1
- Pancreas transcription factor 1 subunit alpha
- Pro-glucagon
- Hexokinase-4
Sequence:
MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSRVHLPFPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPPPPPPGGAVPSGVPAAAREGRLPSGLSASPQPSSIAPLRPQEPR
Protein: adenylate cyclase (EC 4.6.1.1) (Q9W037)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ras-like protein 1
- cAMP-dependent protein kinase catalytic subunit 2
- cAMP-dependent protein kinase catalytic subunit 1
- Bis
- IP06402p
- LD28489p
- Inosine triphosphate pyrophosphatase
- 3',5'-cyclic-AMP phosphodiesterase, isoform I
- Molybdenum cofactor biosynthesis protein 1
- GTP cyclohydrolase 1
Sequence:
MDPAYSKNVVDYRSLGNMPGYEWKLLRYKCRELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMFATIENYEADKSGLRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLVDLDENLHFQQHSPDNDSHKGSIVSVHWLDEKRAER
Protein: Dipeptidyl aminopeptidase 1 (Cathepsin C homolog) (EC 3.4.14.1) [Cleaved into: Dipeptidyl aminopeptidase 1 exclusion domain chain; Dipeptidyl aminopeptidase 1 heavy chain; Dipeptidyl aminopeptidase 1 light chain] (Q8IIJ9)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Thiol protease that cleaves dipeptides from the N-terminus of protein substrates. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine or lysine cannot occupy the P2 position of the substrate. Involved in host hemoglobin degradation by generating dipeptides from hemoglobin-derived oligopeptides.
Subcellular location: Vacuole lumen {ECO:0000269|PubMed:15304495}. Parasitophorous vacuole lumen {ECO:0000269|PubMed:15304495}. Note=In schizonts, the immature form localizes to the parasitophorous vacuole (PubMed:15304495). In trophozoites, the mature form localizes to the digestive (or food) vacuole, an acidic vacuole where host hemoglobin is digested (PubMed:15304495). {ECO:0000269|PubMed:15304495}.
Interaction partners:
- Uncharacterized protein
- Falcilysin
- Serine repeat antigen 9
Sequence:
MAKRIFSVSFLLVLLNVLHICIKFSVADLPTHVETKNLLGKWKILRTKTSPNLTTCGSSQPNKNTYNVGITDYKKYLLENNYEFVSELNVILSDDYVLYGDIYNTQDNEHRSKWKVLAVYDENKRVIGTWTTICDEGFEIKIGNETYAALMHYEPNGKCGPVSDEDSLDSNGDTDCYTTSFSKIRYGWLDVENEKNEHLHGCFYAERIFDNVNEIKHLDSFTIDKDSQNVLQTFTYDTKLNNILNSNNMLYKFGNLQKPTFTKRNNTNVQFNSELNWHRMKHHGKKKPLKKSMLDASRQTYACPCNANEVVDNVINKGDSDNPVSPTLIQLNNNLKNTTQTGNKDTNEMDLENYEDTLNSPKRELEINELPKNFTWGDPWNKNTREYEVTNQLLCGSCYIASQLYAFKRRIEVALTKKLDRKYLNNFDDQLSIQTVLSCSFYDQGCNGGFPYLVSKLAKLQGIPLNVYFPYSATEETCPYNISKHPNDMNGSAKLREINAIFNSNNNMSTYNNINNDHHQLGVYANTASSQEQHGISEENRWYAKDFNYVGGCYGCNQCNGEKIMMNEIYRNGPIVSSFEASPDFYDYADGVYFVEDFPHARRCTIEPKNDGVYNITGWDRVNHAIVLLGWGEEEINGKLYKYWIGRNSWGNGWGKEGYFKILRGQNFSGIESQSLFIEPDFSRGAGKILLEKMQKELGN
Protein: General stress protein, Gls24 family (A0A0H2UNK7)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MGIEEQLGEIVIAPRVLEKIIAIATAKVEGVHSFSNRSVSDTLSKLSLGRGIYLKNVDEELTADIYLYLEYGVKVPKVAVAIQKAVKDAVRNMADVELAAINIHVAGIVPDKTPKPELKDLFDEDFLND
Protein: Large ribosomal subunit protein eL43B (60S ribosomal protein L43-B) (L37a) (YL35) (P0CX26)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA
Protein: FI21939p1 (NADH dehydrogenase (Ubiquinone) 51 kDa subunit-like 2, isoform B (EC 1.6.99.3)) (A1Z9Z6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRQKLKNYLPSVWEQQLRLVQTAKKAGGSKKLGPDRPPIIDPPKGYEPNCKTKFGPLDDCDRVFQNLYGRHDWRLHGACQRGDWHRTAELLEQGPEWIMKQWEFLRQTKSEKVPKMVIVNCAEGEPGTCKDRDILRHEPHKLIEGILLVGVAMGCGRAIVYIRNRFYNEACNLHFALAEAYHHGLLGNSVCGTGIKFDVMVQRGDRYLCGEETAMINCLMGKLGRPRRRPPFLTEKGYFEHPCLVINAESIAVVPTILRRGSQWWAGLGRSYNTGTKLYCLSGQVNNPCTVEEEMSIPLKDLIERHAGGVKGGWDNLAAVFPGGLSTPLLDPSTAGKVLMDFDSLTDAGSGFGCGAVIVMTKDCDPLAIMLRSIQFFEKHTCKQCSYCRDGAIWLPEIFARFVKGQTHPHEIDWTLVIADKMRNSKPICALAYSQVSVAESLVRMFSRKIEERLLKYAKGS
Protein: Solute carrier family 46 member 2 (Thymic stromal cotransporter homolog) (Q8CA03)
Organism: Mus musculus (Mouse)
Function: May act as a transporter.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:28539433}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9BY10}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BY10}. Note=Localizes in acidic vesicles likely late endosomes and/or endolysosomes. {ECO:0000269|PubMed:28539433}.
Interaction partners:
- Zinc finger protein 37
Sequence:
MGPGGTCPWSSRLSGFRVRTWIEPVVASTQVAGSLYDAGLLLVVKESFKSEAGGSSNYSANQSLVEYQEDQQQKAISNFNIIYNLVLGLTPLLSAYGLGWLSDRYHRKISICTAMLGFLLSRIGLLLKVMLDWPVEVMYGAAALNGLCGSFSAYWSGVMALGSLGCSEGRRSVRLILIDLVLGLAGFSGSMASGHLFKQIVGHSAQGLLLTACSVGCAAFALFYSLFVLKVPESKPNKVHPTVDTVSGMMGTYRTLDPDQQDKQNVPRNPRTPGKGKSSQREVVALLFVGAIIYDLAAVGTVDVMALFVLKEPLHWNQVQLGYGMASGYIIFITSFLGVLVFSRCFRDTTMIIIGMLSFGSGALLLAFVKETYMFYIARAIMLFALIPITTIRSAMSKLIKDSSYGKIFVILQLCLTLTGVVTSTIYNKIYQLTLDKFIGTCFVLSSFLSFLAIVPIGVVAYKQVPRSQQGECAEKQRS
Protein: Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) (Q9HCM4)
Organism: Homo sapiens (Human)
Function: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BGS1}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q8BGS1}. Cell membrane {ECO:0000250|UniProtKB:Q8BGS1}; Peripheral membrane protein {ECO:0000305}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q5FVG2}.
Interaction partners:
- Protein crumbs homolog 2
- Protein crumbs homolog 3
- Contactin-associated protein 1
- Nucleoredoxin
- Protein PALS1
- Protein 4.1
- InaD-like protein
- Tight junction protein 1
Sequence:
MLSFFRRTLGRRSMRKHAEKERLREAQRAATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKACATKPEELSVHNNVSTQSNGSQQAWGMRSALPVSPSISSAPVPVEIENLPQSPGTDQHDRKCIPLNIDLLNSPDLLEATIGDVIGASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDTSEKLKQLEMENSPLLSPRSNIDVNINSQEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLETLMLITPADSGSVLKEATDELDALLASLTENLIDHTVAPQVSSTSMITPRWIVPQSGAMSNGLAGCEMLLTGKEGHGNKDGISLISPPAPFLVDAVTSSGPILAEEAVLKQKCLLTTEL
Protein: La ribonucleoprotein 7, transcriptional regulator (D6RF49)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERP
Protein: Mitochondrial Rho GTPase 2 (MIRO-2) (EC 3.6.5.-) (Ras homolog gene family member T2) (Q32LU1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Trafficking kinesin-binding protein 1 isoform X4
- Trafficking kinesin-binding protein 2 isoform X1
- E3 ubiquitin-protein ligase parkin
- PTEN-induced kinase 1.
- Mitochondrial Rho GTPase
- Mitochondrial Rho GTPase 1-A
- Mitofusin 2
- WD repeat-containing protein 90
- Myosin XIX
- Mitofusin 1b
Sequence:
MKRDVRILLLGEPKVGKTSLIMSLVGEEFPEQVPLRAEEITIPADVTPEKVPTHIVDYSENEQTDEVLREEIVKANVVCVVYDVTQEETIDKIRTKWIPLVNGGAEKGSKIPIILVGNKSDLRSGSSMETILPIMNQFSEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEDKQLKAQCVRALSRIFSISDQDNDHILSDAELNCFQKLCFGNPLAPQALEDVKTVVWKNTSDGVQDNGLTLNGFLFLNTLFIQRGRHETTWTILRKFGYDDTLELTDDYLYPVLRVSVGCTTELNHLGHQFLLKLFEKYDEDKDSALSPAELKNLFSVLPYMPWSSTVYSNIPLTDDCYISQHGYLCQWMLLAYLDVHRCLEHLGYLGYPILMEQECQTSAITVTREKALDLDNRQTQRTVFLCKVIGPRGTGKTDFLRAFLQRSTERSDRDPGAPSIYAINTVSIANQDKYLILEEVDVETEFLKAADAACDVACLMYDVSDPDSFNYCASIYKQHYMDSGIPCVVLGSKADLVEVKQHHGMSPSEFCYKHRLPSPLHFSALLTHTHTHIYSKLTWAAMYPHLNGSDMSSTSFWLRVTLGATIAAMLGFALYRAFSRHK
Protein: Flagellum targeting protein kharon1 (Q38A80)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSATVAQRPSTAQERILASNCPPPPPPPPGSPSHRQRAAYNNFGSGVSAMFGFQPTGLVTAIENETQGPVVTRRTKYRDTSEIILGPSKPSQIKHGVRRYDGHDDCSVGLALTDTWIRGYADDEEPPAHVVRQRGPKDNLEGNCCRVKTEETKPRKMLAPGNPPPRTTRPPYSVPEYDGNNAEETCPKRLYRHKDSGNIICPEPLPKGTVIDDRPRGTVRSHRNRSNESVDVLNLGQYSSEQLNEVERKLVAGPREFIPPPLPPRQRPIIARVHTPANATHDIFGTGQGVEDIEPVHCKKRGESAPKRSGEFDIFDPTPLPQQPTKGYNPSDLLVYDEPYVSVQEKREKAAREARRNPEKYCPGNVVTSSHKIEKKTESGVVFHSKSQEITAHGGRARGLYAPRGSSISLC
Protein: Lipolysis-stimulated lipoprotein receptor (A0A0R4ICU6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
- Transmembrane protein 181
Sequence:
MSLGVIFTLLLFTGVTTGINVICTYPRYVVIMFQPVTLRCDFTTTSTTPPLITWKYKSYCRDPIQAALNPSSADNAIAQSNPNYNPNIECADSARTVRIVASKQTAVTLGKEYQGRQISITNNADLSIVQTAWGDSGVYVCSAASAQDLSGNGECYTELIVLDWLLVVLVVLGFLLLLLLIGICWCQCCPHTCCCYVRCPCCPERCCCPRALYEAGKMVKSGIPSQYAATAYAQSMYGQPAYGVGAAMPGIPMMPMQMGVGGPPSNGYGRDYDGASSIGQGSQVPLLQEHDAGGNRSGYRVQADQDGNPTRVLYYMEREVANLDPSRPGIAPGKYSRLDGMSEVSSLHDGPDSRNRGRARPPQLTTVYDDVDENMSTISSVSQHMRRDEPRRGADSRGRARSMENLDDISRGYRDRDDYPPARRDGGPRGGRRGSDDEWSSSGRGYDPVDDRRRRDYSPDNRPRHGDSFRGAGFQGRRTRSRDDLMDLVRDPGRGGRDEYDDSFLREAMEKKKLGEQQRGRSRERLDSESDRSDRYRGHHSGPPPLPLVPASGNPDRRGNHSNFPPPPPPYTEDTDSLPSSKKSNLKKNGAVSRESLVV
Protein: Spindle apparatus protein lin-5 (Abnormal cell lineage protein 5) (P45970)
Organism: Caenorhabditis elegans
Function: Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:18694560}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10629219}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:10629219}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10629219}. Note=Located to the spindle apparatus in a cell cycle- and microtubule-dependent manner. Located at the centrosomes throughout mitosis, at the kinetochore microtubules in metaphase cells, and at the spindle during meiosis (PubMed:10629219). Has enriched expression in the posterior cortex of 1-cell embryos at anaphase, dependent on csnk-1 regulation of pkk-1 (PubMed:18694560). {ECO:0000269|PubMed:10629219, ECO:0000269|PubMed:18694560}.
Interaction partners:
- G-protein regulator 1
- Calponin-homology
- Guanine nucleotide-binding protein alpha-16 subunit
- Guanine nucleotide-binding protein G
- Probable delta-1-pyrroline-5-carboxylate synthase
- Protein let-99
- G-protein regulator 2
- Protein kinase C-like 3
- Dynein light chain roadblock
- Calmodulin-like protein
Sequence:
MSVSTSVVKSMLQLTNYFGSNFTPKTETISSLAELWERHGSMIASMMSCDTREFGTADKFYEVIFRKIATTSLSFMTDSLEPKLAASGDSLEICKFYALFLEYMRKDHSGMLTRALEQASSENRVDTAVLLDMFLFFDNVYSESTADDWWACLRRDDEDQEASSGFRTPKRNNYSLTSLQTPTATARRLRTASSTARRSPIAEAVDSPTMKFMRSERELKQSKARIFGLEQMLGDLEDDKTKLSAENRTLKLSNSDLKSDIAKLKGIAEEAQFRAEELSCDLEAKKDEVHNILQQLNESRMTLRSEQRSLEEADIKKENLTAKLKTVTEDNGKLMKQARELRDLNDYEFARFRQQEQELTETLRATQDQMADLQEQLTGVEKIRASLKSENESLSASVEELSVASLRNKQDADNSKTMLSEELARFEETVDKLRQEKLEALSMANSRIDALRLEHSEREKMMKSTNARLQADLDEERNEKKRLMNLWNELNEKSLNVDKAVHKSNEEFQSMGSCLQNAKRQIEQLEVACKSKDDIIKFQEEQNKRAANLIKNEKAIRDQASAQFAEKLAILKNSLAEKENETVTLKENFASVVMKHKAELEEKELFLQSRVDLIQRLEHEVADLREKESAEIKKSTWMGERIKIFQQAPMRGSRIRCGSPDSLPDFLADNGPTITEEELRAQLATFPRKSIAPSVDDNEFDKGTPIGFKSNMYDGRESICSLDFFDRSSLQRSSMRSESIQLASPSSAGEFKQPFTPSGVTKERVGVLTARNEKVKPHLKCSYASEVGSTNSPSADEENIKKSKKKNRRDSIFSAFSSKKQ
Protein: G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33) (Q5T6X5)
Organism: Homo sapiens (Human)
Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8K4Z6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K4Z6}.
Interaction partners:
- Osteocalcin
- Extracellular calcium-sensing receptor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
- Metabotropic glycine receptor
Sequence:
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI