wanglab/gogpt-training-data huggingface dataset:
Protein: Macrophage stimulating 1 (F7FMS0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Macrophage-stimulating protein receptor
- Serine protease hepsin
- Kunitz-type protease inhibitor 1
- Kunitz-type protease inhibitor 2
- Hepatocyte growth factor receptor
Sequence:
MGWLPLLLLLAQCSRALGQRSPLNDFQLLRGTELRNLLHPVVPGPWQEDVADAEECARRCGPLLDCRAFHYNMSSHGCQLLPWTQHSLRAQLHHSSLCDLFQKKDYVRTCIMDNGASYRGTVARTADGLPCQAWSRRFPNDHKYTPTPKNGLEENFCRNPDGDPRGPWCYTTNRSVRFQSCGIKSCREAVCVWCNGEDYRGEVDVTESGRECQRWDLQHPHSHPFHPEKFPDKALKDNYCRNPDASERPWCYTTDPNVEREFCDLPSCGMLQGQGLGGNLEKTGRRGSTRRGPNLPPTTKGSKSQQRNKVKASNCFRGKGEDYRGTTNTTSAGVPCQRWDAQNPHQHRFVPEKYACKDLRENFCRNPDGSEAPWCFTSRPGLRVAFCYQIPRCTEEVVPEGCYHGSGEQYRGSVSKTRKGVQCQHWSSETPHKPQFTPTSAPHAGLEANFCRNPDGDSHGPWCYTLDPETLFDYCALKRCDDDQPPSILDPPVQVQFEKCGKRVDQSNRLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWVLTARQCIWSCHDPLTGYEVWLGTINQNPQPGEANLQRVSVAKTVCGPAGSQLVLLKLERPVILNHHVARICLPPEQYVVPPGTNCEIAGWGESKGTSNSTVLHVAKMKVISSQECNVKYRRRVQESEICTEGLLAPTGACEGDYGGPLACYTHDCWVLQGLIIPNRVCARPRWPAIFTRVSVFVDWINKVVQLE
Protein: Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Q29RQ3)
Organism: Bos taurus (Bovine)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
Interaction partners:
- Cytoplasmic dynein 1 heavy chain 1
- Dynein light intermediate chain
- Dynein light intermediate chain
- Dynactin subunit 1
- Dynein light chain Tctex-type 1
- Dynein light chain 2
- Dynein light chain 1, cytoplasmic
- Dynactin subunit 2
- Dynein light chain roadblock-type 1
- Dynein light chain roadblock-type 2
Sequence:
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVPDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRRRLHKLGVSKITQVDFLPREVVSYSKETQTPLATHQSEEDEDDEEMVEPKGDQDSEQENEDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGAVELSA
Protein: ABC transporter C family member 8 (ABC transporter ABCC.8) (AtABCC8) (EC 7.6.2.2) (ATP-energized glutathione S-conjugate pump 6) (Glutathione S-conjugate-transporting ATPase 6) (Multidrug resistance-associated protein 6) (Q8LGU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pump for glutathione S-conjugates.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter A family member 5
- ABC transporter I family member 19
Sequence:
MAAFIGSLPWCDVELNLASSCFQRTAIAFVNLLFLCIFYLFLIASCVSTHFIVRGRKKGWIFVAVAICCAITSFIFLGVGLNSLIHGGNDVTEISWVACFVEGIIWVSLAVSLLVNGSKWVNILVSVWWVSFALLDLVAKSGILLQGNGIRILDILTLPMSLLLLLCSWMNLRSSSAAAQDCSVTGLSDPLLTKNPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDTLLGDESSTKERNLVFRAVVKVYFKENIFIAVFAFLRTFAVVSLPLMLYVFVDYANSDHRDLRNGFFNLACLVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGEIVNYIAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLLNLPFAKMLQNCQTQFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLAKAQLTKAFGSFLYWMSPTIVSSVVFLGCALLKSAPLNASTIFTVLATLRVMSEPVKIIPDAISAIIQGNVSFQRLNNFLLDDELKMDEIERSGLDASGTAVDIQVGNFGWEPETKIPTLRNIHLEIKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYVSQTSWIQSGTIRDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRIQLARAVYADADVYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEFLSEVDQILVMEEGTITQSGKYEELLMMGTAFQQLVNAHNDAVTVLPLASNESLGDLRKEGKDREIRNMTVVEKIEEEIEKTDIPGVQLTQEEEKESGYVGMKPFLDYIGVSRGWCLLWSSVLGQVGFVVFQAASTYWLAFAIGIPKITNTMLIGVYSIISTLSAGFVYARAITTAHLGLKASKAFFSGFTNAVFKAPMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFVVAPAVELTAALLIMTYVTWQVIIIALLALAATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTIRAFGTAERFFKNYLNLVDADAVLFFLSNAAMEWVILRIETLQNVTLFTCALLLILIPKGYIAPGLVGLSLSYALTLTQTQVFLTRWYCTLSNSIISVERIKQYMNIPEEPPAIIDDKRPPSSWPSNGTIHLQELKIRYRPNAPLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCILIDGIDISKIGLKDLRMKLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPNKLDSSVSDEGENWSVGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVITVAHRVPTVIDSDMVMVLSFGDLVEYNEPSKLMETDSYFSKLVAEYWASCRGNSSQNLQL
Protein: Uncharacterized endoplasmic reticulum membrane protein C1709.03 (O74728)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSLLRYFIFFIGGCTLALASGVSYTEASVYMSGLSGNENEVPSISPSDSRLVFAHKLGVSRFHKLKSHSGARKIINEMLHSHSELSSFFYAEKSNTFLTIAGLAESELFDTLNPAFRISSCPSSNAFASLMCRYERQLDSLDNGKTTDIYLNDIGGVISIHDSTGVYSQITTTPYKSLEDYEQLFGEDKASMFDISVKQDRVFLSEIYALKILVEFLSSKSQQERSDTSIVIGQLVGLEALYEKYGKDSKIYQVARENMMTLLSMIKQVSSTYTFILLPPIDSSETSTRYHKRQVDMEAFGEEIEEVVASYEKNYNGRCYISEEACSKATNDCSGHGRCSKYGQLDSCYVCQCSNSVVSNAAGQNKTIRWAGESCSKQDISVEFQFFFWFTIIGFGLLIFSIMLLFSIGQEELANVLTSTATVIKKTT
Protein: N(4)-acetylcytidine amidohydrolase (ac4C amidohydrolase) (EC 3.5.1.135) (P67603)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). Can also hydrolyze N(4)-acetyl-2'-deoxycytidine and N(4)-acetylcytosine with lower efficiency. Has weaker activity towards a wide range of structurally different N(4)-acylated cytosines and cytidines.
Interaction partners:
- Cytosine deaminase
- UPF0149 protein YgfB
- Peptidase E
Sequence:
MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPGQTQFYVIEFKCL
Protein: TatD-related DNAse (Q55DK1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Vegetative-specific protein H5
- ABC transporter G family member 10
- cAMP-regulated M3R protein
Sequence:
MNDHDDFPPLGSKPVKRTNNNNNNNNNNSNGFSYRQTTTTTQTAVQPILVPTIIKESTKNEIIDIGANLADKSFERDIDQILERGYNKGVTKIIITGTSVKSSIKAIQLIESNKRKKGLVELFSTVGVHPHSAEETLKMNGGSGEKAQDELRQLIKSNLNVVKSVGECGLDFNRNFSSHATQIEMFDRQIQLGIEFKLPLFIHERDAHKQFCTVVEKYVKDGTMPKSVIHCFTGTEAEARMYVSMGFYIGFTGVIGHDKRGEQLRAILKSGIIPLDRLMIETDCPYMTPHNINAIDKPKQNDPRSKFIRNEPSLLPYVLKTLAQCYNISEKDMALQTFNNTKVFFNLN
Protein: Vacuolar histidine transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) (P38279)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:23169667}; Multi-pass membrane protein {ECO:0000269|PubMed:23169667}. Mitochondrion membrane {ECO:0000269|PubMed:16823961}; Multi-pass membrane protein {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Cystine transporter
Sequence:
MKLIPIILNAKNLSGMAGSISICCWIVVFVPQIYENFRRQSAEGLSLLFIVLWLLGDIFNVMGAMMQNLLPTMIILAAYYTLADLILLIQCMWYDKEKKSILQEVKKNVDPVHLPPANPINETVLQDVFNEYEPLLPRIEEEDSQSYSSLELGRTIVVKERENFFNDFLIVSGVLIAGILSWYISYCSGLDNGIPKKKPAFEQINLPAQILGYLSAILYLGSRIPQIVLNFKRKSCEGVSFLFFLFACLGNTSFIISVLSASWLIGSAGTLLMDFTVFIQFFLYAKPKYEKILIDN
Protein: Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) (P30518)
Organism: Homo sapiens (Human)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23236378}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Beta-arrestin-1
- Vasopressin-neurophysin 2-copeptin
- Guanine nucleotide-binding protein G
- Aquaporin-2
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
- Vasopressin V1a receptor
- Vasopressin V1b receptor
- Guanine nucleotide-binding protein G
- Rho GTPase-activating protein 4
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Protein: Uncharacterized protein YncE (P76116)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Ferrienterobactin receptor
- Enterobactin synthase component B
- Enterobactin synthase component F
- Ferric siderophore reductase
- Pyrroloquinoline quinone transporter
- Iron
- Isochorismate synthase EntC
- NADPH-dependent ferric-chelate reductase
- Colicin I receptor
- Ferric enterobactin-binding periplasmic protein FepB
Sequence:
MHLRHLFSSRLRGSLLLGSLLVVSSFSTQAAEEMLRKAVGKGAYEMAYSQQENALWLATSQSRKLDKGGVVYRLDPVTLEVTQAIHNDLKPFGATINNTTQTLWFGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPRELVADDATNTVYISGIGKESVIWVVDGGNIKLKTAIQNTGKMSTGLALDSEGKRLYTTNADGELITIDTADNKILSRKKLLDDGKEHFFINISLDTARQRAFITDSKAAEVLVVDTRNGNILAKVAAPESLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTFDTPTHPNSLALSADGKTLYVSVKQKSTKQQEATQPDDVIRIAL
Protein: Disease resistance protein ADR1 (Activated disease resistance protein 1) (Q9FW44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Disease resistance (R) protein that mediates resistance against Hyaloperonospora parasitica in a salicylic acid-dependent manner. Also mediates resistance against Erysiphe cichoracearum is both salicylic acid-dependent and partially NPR1-dependent. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Interaction partners:
- tRNA ligase 1
- Protein EDS1
- Toll/interleukin-1 receptor-like protein
- Disease resistance protein RRS1
- Lipase-like PAD4
- Senescence-associated carboxylesterase 101
- LRR protein
- ARM repeat superfamily protein
- Disease resistance protein LAZ5
- Protein DA1-related 4
Sequence:
MASFIDLFAGDITTQLLKLLALVANTVYSCKGIAERLITMIRDVQPTIREIQYSGAELSNHHQTQLGVFYEILEKARKLCEKVLRCNRWNLKHVYHANKMKDLEKQISRFLNSQILLFVLAEVCHLRVNGDRIERNMDRLLTERNDSLSFPETMMEIETVSDPEIQTVLELGKKKVKEMMFKFTDTHLFGISGMSGSGKTTLAIELSKDDDVRGLFKNKVLFLTVSRSPNFENLESCIREFLYDGVHQRKLVILDDVWTRESLDRLMSKIRGSTTLVVSRSKLADPRTTYNVELLKKDEAMSLLCLCAFEQKSPPSPFNKYLVKQVVDECKGLPLSLKVLGASLKNKPERYWEGVVKRLLRGEAADETHESRVFAHMEESLENLDPKIRDCFLDMGAFPEDKKIPLDLLTSVWVERHDIDEETAFSFVLRLADKNLLTIVNNPRFGDVHIGYYDVFVTQHDVLRDLALHMSNRVDVNRRERLLMPKTEPVLPREWEKNKDEPFDAKIVSLHTGEMDEMNWFDMDLPKAEVLILNFSSDNYVLPPFIGKMSRLRVLVIINNGMSPARLHGFSIFANLAKLRSLWLKRVHVPELTSCTIPLKNLHKIHLIFCKVKNSFVQTSFDISKIFPSLSDLTIDHCDDLLELKSIFGITSLNSLSITNCPRILELPKNLSNVQSLERLRLYACPELISLPVEVCELPCLKYVDISQCVSLVSLPEKFGKLGSLEKIDMRECSLLGLPSSVAALVSLRHVICDEETSSMWEMVKKVVPELCIEVAKKCFTVDWLDD
Protein: Centromere protein Cenp-F N-terminal domain-containing protein (Q8C0X4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSWALEEWKEGLPSRALQKIQELEGQLEKLKKEKQQRQFQLDSLEAALQKQKQKVEDGKTEGADLKRENQRLMEICEHLEKSRQKLSHELQVKESQVNLQESQLSSCKKQIEKLEQELKRCKSEFERSQQVAQSADVSLNPCSTPQKLFATPLTPSSTYEDLKEKYNKEVEERKRLEEEVKALHAKKVSLPFSQATMNHRDIARHQASSSVFPWQQENTPSRLSSDALKTPLRRDGSAAHFLGEEVSPNKSSMKTGRGDCSSLPDLKSKMTELELRLQGQEKEMRSQVNKCQDLQVQLEKTKVELIEKERILNKTRDEVVRSTAQYDQAAAKCTTLEQKLKTLTEELSCHRQNAESAKRSLEQRIKEKEKELQEELSRQHQSFQALDSEYTQMKTRLTQELQQVKHLHSTLQLELEKVTSVKQQLERNLEEIRLKLSRAEQALQASQVAENELRRSSEEMKKENSLIRSQSEQRTREVCHLEEELGKVKVSLSKSQNFAEEMKAKNTSQEIMLRDLQEKLNQQENSLTLEKLKLALADLERQRNCSQVLLKKREHHIDQLNNKLNKIEKEFETLLSALELKKKECEELKEEKNQISFWKIDSEKLINQIESEKEILLGKINHLETSLKTQQVSPDSNERIRTLEMERENFTVEIKNLQSMLDSKMVEIKTQKQAYLELQQKSESSDQKHQKEIENMCLKANKLTGQVESLECKLQLLSSEVVTKDQQYQDLRMEYETLRDLLKSRGSSLVTNEDNQRSSEDNQRSSEDNQRGSLAFEQQPAVSDSFANVMGRKGSINSERSDCSVDGGRSPEHIAILQNRVTSLESSLESQNQMNSDLQMRCEELLQIKGEVEENLSKAEQIHQNFVAETNQCISKLQEDAAVHQNIVAETLATLESKEKELQLLKEKLEAQQTEVQKLNKNNCLLEGTLKELQLLSDTLSSEKKEMNSIIS
Protein: Ankyrin repeat and SOCS box protein 3 (ASB-3) (Q9Y575)
Organism: Homo sapiens (Human)
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:39162488, ECO:0000269|PubMed:39266719}.
Interaction partners:
- Elongin-C
- Cullin-5
- Elongin-B
- Glutathione-specific gamma-glutamylcyclotransferase 2
Sequence:
MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
Protein: (+)-vincadifformine 19-hydroxylase (EC 1.14.14.-) (Cytochrome P450 71BY3) (P0DO22)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of the monoterpenoid indole alkaloids (MIAs, e.g. echitovenine, tabersonine, lochnericine, 19-hydroxytabersonine and horhammericine) biosynthetic pathway; MIAs are used in cancer treatment and other medical applications. Cytochrome P450 catalyzing the hydroxylation of (+)-vincadifformine to (+)-minovincinine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:I1TEM1}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MELDECSPSIFIISFIFIAISIAILRRIRPKKTKALPPGPWKLPLIGNLHQFISRDSLPYKILRDLAQKHGPLMHLQLGEVSAVVASSPEMAKVITRTKDLEFADKPAIRAIRIVTYDYLDIAFNSYGKYWREMRKIFVQELLTPKRVRSFWSAREDVFSNLVKTINSANGKSINLTKLISSTTNSIINRVALGNVPYEREIFMELIKQLLTAAGGFKLVDLFPSYKIIHVLEGTERKLWKILGKIDKILDKVIDEHRENLLRTGKGSGENGQEDIVDILLKIEDGGELDHDIPFGNNNIKALLFDIISGGSDTSSTTIDWAMSEMMKNPQVMSKAQKEIREAFNGKKKIDENDVQNLKYLKSVIQETLRLHPPAAFLMRQCREECEIGGYHIPVGTKVFINIWAMGRDPEHWPNPESFIPERFENIPYDFTGSEHQLATFPFGSGRRICPGISFGLANVELSLALLLYHFNWQLPDSSTDLDMTEAIGIAARRKYDLHLIPTSYM
Protein: D-galactonate dehydratase family member SeV_A0456 (EC 4.2.1.-) (D-gluconate dehydratase) (EC 4.2.1.39) (B5QBD4)
Organism: Salmonella virchow (strain SL491)
Function: Has low D-gluconate dehydratase activity (in vitro), suggesting that it has no significant role in D-gluconate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro).
Interaction partners:
Sequence:
MSNLKITNVKTILTAPGGIDLAVVKIETNEPGLYGLGCATFTQRIFAVKSAIDEYMAPFLVGKDPTRIEDIWQSGVVSGYWRNGPIMNNALSGVDMALWDIKGKLAGMPVYDLLGGKCRDGIPLYCHTDGGDEVEVEDNIRARMEEGYQYVRCQMGMYGGAGTDDLKLIATQLARAKNIQPKRSPRSKTPGIYFDPDAYAKSVPRLFDHLRNKLGFGIEFIHDVHERVTPVTAINLAKTLEQYQLFYLEDPVAPENIDWLKMLRQQSSTPISMGELFVNVNEWKPLIDNRLIDYIRCHVSTIGGITPAKKLAVYSELNGVRTAWHGPGDISPVGVCANMHLDLSSPNFGIQEYTPMNDALRDVFPGCPEIDHGYAYLNDKPGLGIDIDEAKAAKYPCEGGIPSWTMARTPDGTASRP
Protein: Nucleoside permease NupG (Nucleoside-transport system protein NupG) (P0AFF4)
Organism: Escherichia coli (strain K12)
Function: Broad-specificity transporter of purine and pyrimidine nucleosides. Can transport adenosine, uridine, thymidine, cytidine, deoxycytidine, guanosine and inosine. Can also transport xanthosine, but with a very low affinity. Transport is driven by a proton motive force.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02049, ECO:0000269|PubMed:15513740, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:3311747, ECO:0000269|PubMed:33640454}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02049, ECO:0000269|PubMed:33640454}.
Interaction partners:
- Nucleoside permease NupC
- Nucleoside-specific channel-forming protein Tsx
Sequence:
MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGASIGAVYSSLGIAAVFMPALLGIVADKWLSAKWVYAICHTIGAITLFMAAQVTTPEAMFLVILINSFAYMPTLGLINTISYYRLQNAGMDIVTDFPPIRIWGTIGFIMAMWVVSLSGFELSHMQLYIGAALSAILVLFTLTLPHIPVAKQQANQSWTTLLGLDAFALFKNKRMAIFFIFSMLLGAELQITNMFGNTFLHSFDKDPMFASSFIVQHASIIMSISQISETLFILTIPFFLSRYGIKNVMMISIVAWILRFALFAYGDPTPFGTVLLVLSMIVYGCAFDFFNISGSVFVEKEVSPAIRASAQGMFLMMTNGFGCILGGIVSGKVVEMYTQNGITDWQTVWLIFAGYSVVLAFAFMAMFKYKHVRVPTGTQTVSH
Protein: Uncharacterized protein 6 (P86725)
Organism: Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone)
Subcellular location: Secreted {ECO:0000269|PubMed:21050442}.
Interaction partners:
Sequence:
MGYFPYLAVFVCLLASGDAQWKGLRGSTKASWVRVVSPTLNVTQEAYIWDADSGISFISRSKLLTGTSINRNRAYTDYNQPKIAIKFRKDVGRTCILLDVASALIGTFNETSTNLQALTVLDTTEEKSYQSVGTVLSATSQSAFDLQHPFIQKKCSDRNYNYLATTELTAGAAPPPASDKFTVFTTWGKVHLYILQSTGLVITTTTEAP
Protein: UBX domain protein 1 (E9PRQ7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEEQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS
Protein: cDNA FLJ77654, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 4 (GNB4), mRNA (A8K3F6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSELEQLRQEAEQLRNQIQDVRKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIVWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
Protein: E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5) (Q9UII4)
Organism: Homo sapiens (Human)
Function: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:20542004}. Cytoplasm {ECO:0000269|PubMed:22093708}. Note=Associated with the polyribosomes, probably via the 60S subunit.
Interaction partners:
- Ubiquitin-like protein ISG15
- Ubiquitin/ISG15-conjugating enzyme E2 L6
- Ubiquitin-like modifier-activating enzyme 7
- Interferon-induced GTP-binding protein Mx1
- Antiviral innate immune response effector IFIT1
- Antiviral innate immune response receptor RIG-I
- Ubl carboxyl-terminal hydrolase 18
- 2'-5'-oligoadenylate synthase-like protein
- Interferon-induced protein with tetratricopeptide repeats 3
- Interferon-induced protein with tetratricopeptide repeats 2
Sequence:
MERRSRRKSRRNGRSTAGKAAATQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQLDYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG
Protein: Gamma-crystallin S (Beta-crystallin S) (Gamma-S-crystallin) (P22914)
Organism: Homo sapiens (Human)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Alpha-crystallin A2
- Phakinin
- Alpha-crystallin B chain
- Gap junction alpha-8 protein
- Gap junction alpha-3 protein
- Filensin
- Pituitary homeobox 3
- Lens fiber major intrinsic protein
- Heat shock factor protein 4
Sequence:
MSKTGTKITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE
Protein: Hematopoietically-expressed homeobox protein hhex (Homeobox protein hex) (Q9IAV3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
- Forkhead box A3.
- Prospero homeobox 1a
- Protein Wnt
- GATA-binding protein 6
- Forkhead box protein A2
- SRY-box containing gene 17
- Forkhead box E1.
- Paired box protein Pax-8
- Fatty acid-binding protein 10-A, liver basic
- Forkhead box A1
Sequence:
MQFQHPHAPLYAPAPAPPAHPTPFYIEDILGRTGSSSGPVVPTPTLPSPNSSFTSLIPSYRTPIYELTPIHPVLSQYASMYPFQRSVGDFAHALIRHDPLGKPLLWSPFIQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPPSTGKREAEDSDTRRLSDAAARARELESGASTDSEELLDIEDEHQFTL
Protein: Beta-amylase (EC 3.2.1.2) (1,4-alpha-D-glucan maltohydrolase) (P16098)
Organism: Hordeum vulgare (Barley)
Interaction partners:
Sequence:
MEVNVKGNYVQVYVMLPLDAVSVNNRFEKGDELRAQLRKLVEAGVDGVMVDVWWGLVEGKGPKAYDWSAYKQLFELVQKAGLKLQAIMSFHQCGGNVGDAVNIPIPQWVRDVGTRDPDIFYTDGHGTRNIEYLTLGVDNQPLFHGRSAVQMYADYMTSFRENMKDFLDAGVIVDIEVGLGPAGEMRYPSYPQSHGWSFPGIGEFICYDKYLQADFKAAAAAVGHPEWEFPNDVGQYNDTPERTQFFRDNGTYLSEKGRFFLAWYSNNLIKHGDRILDEANKVFLGYKVQLAIKISGIHWWYKVPSHAAELTAGYYNLHDRDGYRTIARMLKRHRASINFTCAEMRDLEQSSQAMSAPEELVQQVLSAGWREGLNVACENALPRYDPTAYNTILRNARPHGINQSGPPEHKLFGFTYLRLSNQLVEGQNYVNFKTFVDRMHANLPRDPYVDPMAPLPRSGPEISIEMILQAAQPKLQPFPFQEHTDLPVGPTGGMGGQAEGPTCGMGGQVKGPTGGMGGQAEDPTSGIGGELPATM