wanglab/gogpt-training-data huggingface dataset:
Protein: Elongation factor Tu, mitochondrial (Q9ZT91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase EFR
- Polyprotein of EF-Ts, chloroplastic
- Elongation factor Ts, mitochondrial
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL36c
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein bL31c
- Large ribosomal subunit protein uL18z
Sequence:
MASVVLRNPSSKRLVPFSSQIYSRCGASVTSSYSISHSIGGDDLSSSTFGTSSFWRSMATFTRNKPHVNVGTIGHVDHGKTTLTAAITKVLAEEGKAKAIAFDEIDKAPEEKKRGITIATAHVEYETAKRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSGPDGPMPQTKEHILLARQVGVPSLVCFLNKVDVVDDPELLELVEMELRELLSFYKFPGDDIPIIRGSALSALQGTNDEIGRQAILKLMDAVDEYIPDPVRVLDKPFLMPIEDVFSIQGRGTVATGRIEQGVIKVGEEVEILGLREGGVPLKSTVTGVEMFKKILDNGQAGDNVGLLLRGLKREDIQRGMVIAKPGSCKTYKKFEAEIYVLTKDEGGRHTAFFSNYRPQFYLRTADITGKVELPENVKMVMPGDNVTAVFELIMPVPLETGQRFALREGGRTVGAGVVSKVMT
Protein: Glucose-induced degradation protein 8-B homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) (E7FGY2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NWU2}. Nucleus {ECO:0000250|UniProtKB:Q9NWU2}. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. {ECO:0000250|UniProtKB:Q9NWU2}.
Interaction partners:
- Armadillo repeat-containing protein 8
- GID complex subunit 4 homolog
- E3 ubiquitin-protein transferase RMND5B
- WD repeat-containing protein 26
- Ran-binding protein 10
- Ran-binding protein 9
- Armadillo repeat containing 6.
- Armadillo repeat-containing 3
- WD repeat domain 26a.
- SPRY domain-containing 3
Sequence:
MMSYAEKPEDITRDEWMEKLNNVHIQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLDSLDERIKIREMVLKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRLRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDNPEESPFGDLLNMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGTIEDPK
Protein: Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) (Q0KK55)
Organism: Mus musculus (Mouse)
Function: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence (By similarity).
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:17984326}. Perikaryon {ECO:0000269|PubMed:17984326}.
Interaction partners:
- Diacylglycerol kinase iota
- Ras-related protein Rap-1A
- RAS, guanyl releasing protein 3
- Guanine nucleotide exchange factor subunit RIC1
- Neutral amino acid transporter 9
- Engulfment and cell motility protein 1
- Dedicator of cytokinesis protein 1
- WD repeat-containing protein 41
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
- Ragulator complex protein LAMTOR3
Sequence:
MQAMDPASRGFYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQTLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDLTGNTFEAHIYSLGATLKAALEYVPEPELEPKLSTDLEGLLSQMQAEDPRERPDLASIIALCEEKMQPVSSCRLCRSLSAIGRRVLSIESFGAFQELSENTWRGRPAPRNVGPKKMPGDLSTDPEALFPSKGLLQPPASRDAEQEAGQRPRAPSPKPLLSAPVRNGENPGQEGLADLVLDARCPLGELDRDNLRRSRLKKAQTFPRLLQESTETSTLCLSLNGSRNQLAISEFFPPDPRKLFLEGKNGLSGFKTQSKSRLWPEQEPGVQLDKTPGAGRNPHRSPGASGQLEASSPSQGSVEYKPSPSPVDAGDSDHEGHIPRSEEKIPEESRQPGSTATEQSLSLKDLLSKLGRPFREYELWALCLSCLSTLQTHKEHPAHLCLDNVLVAEDGTVFFGPPPANGAYNSLFLAPEVSEEKLVTEKASVYCVAAVLWTAAKFSVPRDHKLALPRRLKTLLLDMARRHASERPSAAEAIKVCSSYLLQRGMDSSKILAHLRASTCKVHPEEETIGLQNAFSVVELKSTTAPAPESSPGFLQVSNDTKLVAVPGPVPGLPPCCKEACELPAAFTSEATHFKPIVLAQDASVTRDQLALPSESNEKPKEGSGHLDREGTRKQAALELVEATDLKMSNQLSPGPELQGATPDPDGDSGSPSSATECSCPHGPALVTQQKGTSGTPSSPASSLPPEHRPDGEGPLGTTVLPGPTSASQGSRHPCKPPRGKAAASPSSPRGSDGHPEKPRPADRKLCPSSVDTSSPPKMTACPSLQEAMRLIQEEFAFDGYMDNGLEALIMGEYIYALKDLTFATFCGAISEKFCDLYWDEQLLKNLFKVVNGPASPSESTSEEPGSQPEHSPSRCSLSSKRPSLHGLGKEKPATTWGSGGPCSPTALSDIDSDTLSQGNFEVGFRSQKSIKVTREQQPEAEVGGQPGPSQDSTSHASDTVARLARSEDGGPAGSPGASDFQNCSPGWSSAFYEADCFGADVYNYVKDLERQKTNGHTELEAQSPELEQQLMIEKRNYRKTLKFYQKLLQKEKRNKGSEVRTMLSKLRGQLDEMKSKVQFLSLVKKYLQVMYAERWGLEPCALPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGSGRQKKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRISSTLSRAHQDPTSTFTKIYRRSLCVLQAWVEDCYTVDFIRNAGLLGQLEDFISSKILPLDGTAEHLLALLEVGTERRADSASRGADLEDPKEAEEDTRPFNALCKRFSEDGITRKSFSWRLPRGNGLVLPHHKERQYTIASALPKPCFFEDFYGPYAKASEKGPYFLTEYSTNQLFTQLTLLQQELFQKCHPVHFLNSRALGVMDKSAAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILGGLEHLAVRQSPAWRILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVASQVHAFQENPYTFSPDPKLQAHLKQRIARFSGADVSILAADNRANFHQIPGEKHSRKIQDKLRRMKATFQ
Protein: Actin-related protein 6 (Protein EARLY IN SHORT DAYS 1) (Protein SUPPRESSOR OF FRIGIDA 3) (Q8LGE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Binds to the promoter region of FLC chromatin. Required for the activation of FLC and FLC/MAF genes expression to levels that inhibit flowering, through both histone H3 and H4 acetylation and methylation mechanisms. Involved in several developmental processes including organization of plant organs, leaves formation, flowering time repression, and fertility. Modulates photoperiod-dependent epidermal leaves cell development; promotes cell division in long days, and cell expansion/division in short days. May be involved in the regulation of pathogenesis-related proteins (PRs).
Subcellular location: Nucleus {ECO:0000269|PubMed:16141450, ECO:0000269|PubMed:16155178, ECO:0000269|PubMed:17470967}. Cytoplasm {ECO:0000269|PubMed:16141450}. Note=Localized in the nucleus during the interphase, but is released into the cytoplasm during the mitotic phase (PubMed:16141450). Associated to heterochromatin (PubMed:16141450). Localized at the nuclear periphery when interacting with SWC6 (PubMed:16155178, PubMed:17470967).
Interaction partners:
- SWR1 complex subunit 6
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- SWR1-complex protein 4
- SWR1 complex subunit 2
- Actin-related protein 4
- RuvB-like protein 1
- Methyl-CpG-binding domain-containing protein 9
- Transcription initiation factor TFIID subunit 14b
- Protein EIN6 ENHANCER
- RuvB-like helicase
Sequence:
MSNIVVLDNGGGLIKAGQGGERDPTTVIPNCLYKPLSSKKFIHPSPLTTLSDEIDLTSAAVRRPIDRGYLINSDLQREIWSHLFTSLLHIAPSSSSLLLTEAPLSIPSVQRTTDELVFEDFGFSSLYIAHPQSLVHLYEASRQPDSILSKTQCSLVVDCGFSFTHAVPVLHNFTLNHAIKRIDLGGKAFTNYLKELVSYRSINVMDETFLVDDAKEKLCFVSLDLLRDLRLARNGNTLIKSTYVLPDGVTHTKGYVKDPQAAKRFLSLSEKESVVVMDKVGERKKADMNKNEIDLTNERFLVPETLFQPADLGMNQAGLAECIVRAINSCHSYLQPVLYQSIILTGGSTLFPQLKERLEGELRPLVPDHFDVKITTQEDPILGVWRGGSLLASSPDFESMCVTKAEYEELGSARCRRRFFH
Protein: Tetratricopeptide repeat protein SKI3 (Protein SKI3 homolog) (AtSKI3) (F4I3Z5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22511887}.
Interaction partners:
- DExH-box ATP-dependent RNA helicase DExH11
- WD repeat-containing protein VIP3
- DExH-box ATP-dependent RNA helicase DExH15 chloroplastic
- DExH-box ATP-dependent RNA helicase DExH9
- DExH-box ATP-dependent RNA helicase DExH10
- Exosome complex component RRP4 homolog
- Exosome complex component RRP45B
- Exosome complex component RRP45A
- Exosome complex exonuclease RRP46 homolog
- Ribosomal RNA-processing protein 42
Sequence:
MELEQLKKSVEENPDDSSLQFELGLYLWDNGGDSEKAAEHFVLSAKSDPNNAVAFKYLGHYYSRVTLDLNRAAKCYQRAVLINPNDSDSGEALCDLFDRQGKEILEIAVCRDASEKSPKAFWAFCRLGYIQLHQKKWSEAVQSLQHAIRGYPTMSDLWEALGLAYQRLGMFTAAIKAYGRAIELDETKIFALVESANIFLMLGSYRKGVELFEQALKISPQNISVLYGLASGLLSWSKECINLGAFGWAASLLEDARKAAKASSELASSMSCIWKLHGDIQLTYARCFPWSGGTENSEFTLKTFSDSILSWRSICYSAALSAKASYQRALHLAPWQANVYTDIAITCDLVSSLSDDSDTSSSWKLPEKMVLGALLLECENSEFWVALGCMSDNSALKLHALIRALHLDVSLAVAWAFMGQIFRESDEMKFAKQAFDCARSIDPTLALPWAGSADTYARESTSDEAFESCLRAAQISPLAEFQVGLAWLALLQGNISSPQIFACIEQAVQRSPYYPEPHNLHGLVCEARHNYHTAIASYRLALAAMSIYPESSVKSHAGKVSINLVRSLSKAGRFKESVMECANLKSKGLLDAGGLQIYAFSLWRTGQNDSALSVIRDLAGRISTREKTSIAFPISFICSLLYCISGLDSAITSIQKMPKDFFQSSKISFIVSAIHSLDQSDRLQSIVASTRSYITSQEEIVAMHYLIALSKLLKTGAGDFLGYEKGIAHLSKAIHMYPHSNLIRNLLGYILLAGEGMKDACTASRCCIINVSECANKEGLKSALEVLGGGSVACNVIGNTAPRFSFPTCHCQYLNAPVVVVELQRFLHQEPSNSSVRYLLILNLVQKAREQRFPRQLCRAIERLISVALSDETCSKEGEYKKFQLLLCASEISLQMGNIAESINHARKASSLSLPSSYLFLGHLQLCRAYAANGSTKNMQEEYRACLELKTDSNIGWICLKLIESQYNLEPDANLLEMSLQECSSQKKNSWKEWMAVYSLARGLDSTGKKDFFSAEEFLAQACSLLNSESCLLLCHGAVCMELARQSNDSQFLSLAVKSLSKVQASSLFPLPIVYTLLAQAHGSLGSKEKWEKNLRLEWFCWPPEMRPAEVYFQMHILARQSEDRPETTSGIENYQSPEKWVIRAIHTDPSCRRYWKVLDKLVQHPMS
Protein: Linear ubiquitin E3 ligase, isoform H (M9PC77)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTTHQLLNKNVRTMPSWVMEANDRIGPKPPPTPPNGVAGGLPKAPALPPKAKSTPEPDYEIIEFSSQQYSNEPMKTTVIRTKTPDNKLKCTLCGSQNPWVTCAECAGQIFCASCDDMFHKHPKRKQHMRKAVEQGTPPIPPKAQAGGGAPPPVAPPRRSKRGLLTPFLGRKDQMLPPPSPTPSHKSLGGWRGSLGGGATPPVPPIATSSANQMNNRPLPDPPRSEGGGSSRSGTPKSVFDTIQRPPSVQLEKIKSKASATLDRMAILQQRYRQQKARQDLSANSEQHLSNEAGFEHWSNISPSPSHFRSGSMSSGLNSSHFDLSDDSQFHNSLLLQQRQAAGAQRRQMSTSVFNLNSNPRRPLSEAQNGGAWLANQRIQQAQSLAQLNCAGCQQSQQHPGWAQHPHQALPQHQHPDQWSQFGSQQQFNNSNLSLNVGPGYMSQQHHPHYPPPVFMTQRGMMPNVYPGAPGYPMMHPGVMGMPPSAASRAASRSRYAASPTPSRKSMSLRRKRNSYVDDELTDDEDSDQDDRRSLVSNRSGMTSASRSQHHQNHIQPRQRRLSSASQLIASDELDGDQVHHKMRNRRGSIAKSVQSEWLPERRENEGTLTRNKTATDSARTSRIYSDLESEGSGARALVQAKIQQKLQEADQHKSSKKAEPKRKPEMKDENTQAAAVVQKVVVPPAHEESASEYEEVVEEVTASESEAEAQTAPDPQEVPDEIGADDLGPPPSTPDHEWECEFCTFVNEPNIKICSICCKTPSKPPVQPNKAKKVEEKPQPPAEKSNNIKASSKTETKPVQKPTTKSQQPSQKSVAALSKTTHTNSTSSSKASPAVNSKTTSSIPIKTPSKSTLKTSSENESDNSLAKSLLHKGRIQKRISFFEGTKT
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (K7ENP9)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
XEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRPRLTDT
Protein: Cell division cycle 2 (Cyclin dependent kinase 1) (Cyclin-dependent kinase 1 isoform 1) (C0SW08)
Organism: Sus scrofa (Pig)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- G2/mitotic-specific cyclin-B1
- Cyclin B2
- Cyclin A1
- M-phase inducer phosphatase 3
- Serine/threonine-protein kinase PLK
- Cell division cycle protein 20 homolog
- Wee1-like protein kinase
- Aurora kinase B
- M-phase inducer phosphatase
- M-phase inducer phosphatase
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALNHPYFNDLDNQVKRM
Protein: Galectin-2 (Gal-2) (Q9Z144)
Organism: Rattus norvegicus (Rat)
Function: This protein binds beta-galactoside. Its physiological function is not yet known.
Interaction partners:
- Galanin peptides
- Spexin
- Galectin-1
- Galanin receptor type 2
Sequence:
MSEKFEVTNLNMKSGMSLKIKGKIHNDVNSFTINLGQGKETLNLHFNPRFNESTIVCNTLDGSSWGQEQRENHSCFSPGSEVKLTLTFQDKDFKVTLPDGHSLTFPNRLGHNHLRYLSMDGLQISSFKLE
Protein: Iron/ascorbate oxidoreductase family protein, putative (EC 1.2.3.4) (Q57XH4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAHGSIPVIDVGPLFCDGEKGMMDVAKQIDHACRTWGVFLVVGHPIPRERTEKLMEMAKAFFSLPLEEKLKVDIRKSKHHRGYGCLDAENVDPTKPFDCKETFNMGCHLPEDHPDVAAGKPLRGPNNHPTQVKGWVELMNRHYREMQEFALVILRALALAIGLKKDFFDTKFDEPLSVFRMLHYPPQKQGTRYPIVCGEHTDYGIITLLYQDSVGGLQVRNLSDEWVDVEPLEGSFVVNIGDMMNMWSNGRYRSTPHRVRLTTTDRYSMPFFCEPNPYTVIKCLDHCHSPSNPPKYPPVRAVDWLLKRFAETYAHRKTKM
Protein: V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) (P21281)
Organism: Homo sapiens (Human)
Function: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:29993276}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasm {ECO:0000250|UniProtKB:P62814}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
Interaction partners:
- V-type proton ATPase subunit H
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit F
- V-type proton ATPase 116 kDa subunit a 4
- V-type proton ATPase subunit D
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit d 2
- V-type proton ATPase subunit d 1
- V-type proton ATPase 16 kDa proteolipid subunit c
Sequence:
MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
Protein: Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Testis-expressed gene 189 protein) (Transcription factor-like protein MRG15) (P60762)
Organism: Mus musculus (Mouse)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UBU8}.
Interaction partners:
- MRG/MORF4L-binding protein
- PHD finger protein 12
- Inhibitor of growth protein 3
- YEATS domain-containing protein 4
- Histone acetyltransferase KAT5
- DNA methyltransferase 1-associated protein 1
- Transformation/transcription domain-associated protein
- Paired amphipathic helix protein Sin3a
- Chromatin modification-related protein MEAF6
- Vacuolar protein sorting-associated protein 72 homolog
Sequence:
MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTREDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV
Protein: Alpha-sarcoglycan (Alpha-SG) (50 kDa dystrophin-associated glycoprotein) (50DAG) (Adhalin) (Dystroglycan-2) (Q16586)
Organism: Homo sapiens (Human)
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Beta-sarcoglycan
- Gamma-sarcoglycan
- Delta-sarcoglycan
- Dystroglycan 1
- Sarcospan
- Dystrophin
- Alpha-1-syntrophin
- Beta-1-syntrophin
- Utrophin
- Caveolin-3
Sequence:
MAETLFWTPLLVVLLAGLGDTEAQQTTLHPLVGRVFVHTLDHETFLSLPEHVAVPPAVHITYHAHLQGHPDLPRWLRYTQRSPHHPGFLYGSATPEDRGLQVIEVTAYNRDSFDTTRQRLVLEIGDPEGPLLPYQAEFLVRSHDAEEVLPSTPASRFLSALGGLWEPGELQLLNVTSALDRGGRVPLPIEGRKEGVYIKVGSASPFSTCLKMVASPDSHARCAQGQPPLLSCYDTLAPHFRVDWCNVTLVDKSVPEPADEVPTPGDGILEHDPFFCPPTEAPDRDFLVDALVTLLVPLLVALLLTLLLAYVMCCRREGRLKRDLATSDIQMVHHCTIHGNTEELRQMAASREVPRPLSTLPMFNVHTGERLPPRVDSAQVPLILDQH
Protein: DNA translocase FtsK (Q9I0M3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (Probable).
Subcellular location: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
Interaction partners:
- Cell division protein FtsQ
- Cell division protein FtsZ
- Tyrosine recombinase XerD
- Cell division protein FtsL
- Cell division protein FtsA
- Peptidoglycan D,D-transpeptidase FtsI
- Tyrosine recombinase XerC
- Probable peptidoglycan glycosyltransferase FtsW
- Cell division protein ZipA
- Chromosomal replication initiator protein DnaA
Sequence:
MRRKNSDLKDSTTASHAAAWRQQLHSRLKEGVLIALGALCLYLWMALLTYDSADPSWSHSSQVDQVQNAAGRLGAVSADILFMTLGYFAYLFPLLLGIKTWQVFRRRNLPWEWNTWLFSWRLVGLIFLILAGSALAYIHFHASGHMPASASAGGAIGQSLGRVAVDALNVQGSTLVFFALFLFGLTVFADLSWFKVMDVTGKITLDFFELIQNAFNRWMGARAERKQLVAQLREVDERVAEVVAPSVPDRREQSKAKERLLEREEALAKHMSEREKRPPPKIDPPPSPKAPEPSKRVLKEKQAPLFVDTAVEGTLPPLSLLDPAEVKQKSYSPESLEAMSRLLEIKLKEFGVEVSVDSVHPGPVITRFEIQPAAGVKVSRISNLAKDLARSLAVISVRVVEVIPGKTTVGIEIPNEDRQMVRFSEVLSSPEYDEHKSTVPLALGHDIGGRPIITDLAKMPHLLVAGTTGSGKSVGVNAMLLSILFKSTPSEARLIMIDPKMLELSIYEGIPHLLCPVVTDMKEAANALRWSVAEMERRYRLMAAMGVRNLAGFNRKVKDAEEAGTPLTDPLFRRESPDDEPPQLSTLPTIVVVVDEFADMMMIVGKKVEELIARIAQKARAAGIHLILATQRPSVDVITGLIKANIPTRIAFQVSSKIDSRTILDQGGAEQLLGHGDMLYLPPGTGLPIRVHGAFVSDDEVHRVVEAWKLRGAPDYIEDILAGVDEGGGGGGSFDGGDGSGEGSEDDPLYDEAVRFVTESRRASISAVQRKLKIGYNRAARMIEAMEMAGVVTPMNTNGSREVIAPAPVRD
Protein: Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like (Endoplasmic reticulum-to-nucleus signaling 1-like) (Inositol-requiring protein 1-like) (Q9SF12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock 70 kDa protein BIP3
- Heat shock 70 kDa protein BIP1
- Heat shock 70 kDa protein BIP2
- bZIP transcription factor 60
Sequence:
MWLLAISLVGLLVVVVCVFLRFSKDKGLDGIVNEKKRDKNSAPRVSASGEDGTKNEQVEKKSDPSGGLGEENEKTNSESKVLSVPSDQNINKTLPVMLPSLELRKYDENETPGKVVNRRLLVSTNEMKYGRNGYEVFQGVYGRRSSVAVKCLDLAHTTEAFIQNEIDNHCLCDDHSNIIRFHGLEQDQSFAYICLEPWKCSLDDLIKLSVRRTKRDTQAVAPVDDLEKVMKRIKFWKEKGKPLPLTPMLKLMRDVVCGLAHLHKLKTIHRNLNPQNVLIIVKDMTLTAKISDMSLSKHLGGKKSSYKHLATCSGSSGWQAPEQLNKDKKKKEDFPADMFNFGCLLHYAVMGTHPFGSPSERDTNIKTNNKTNLSLVTNLEAINLIEQLLNYKPDLRPSATQVLLHPLFWDSEKRLFFLREASDRIELDITMWGDLNKTIAPRVLGESKDWASKLGKTFITHIENLAQAQPGQESRQYNRSYKYWSLRHLLRLIRNILSHHREILDDPKIKEMVGKVPEGLDIFFTARFPNLMMEIYAFISMHCKGEEAFEKYFN
Protein: Transcription factor TGA6 (bZIP transcription factor 45) (AtbZIP45) (Q39140)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'-TGACGTGG-3') another cis-acting element found in plant histone promoters (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Regulatory protein NPR1
- Regulatory protein NPR3
- Regulatory protein NPR4
- Glutaredoxin-C9
- Protein NIM1-INTERACTING 1
- DEAD-box ATP-dependent RNA helicase 36
- Protein NUCLEOLAR FACTOR 1
- Pre-mRNA-splicing factor SYF2
- Nucleolar-like protein
- Regulatory protein NPR5
Sequence:
MADTSSRTDVSTDGDTDHRDLGSDRGHMHAAASDSSDRSKDKLDQKTLRRLAQNREAARKSRLRKKAYVQQLENSRLKLTQLEQELQRARQQGVFISSSGDQAHSTGGNGALAFDAEHSRWLEEKNRQMNELRSALNAHAGDTELRIIVDGVMAHYEELFRIKSNAAKNDVFHLLSGMWKTPAERCFLWLGGFRSSELLKLLANQLEPMTERQVMGINSLQQTSQQAEDALSQGMESLQQSLADTLSSGTLGSSSSDNVASYMGQMAMAMGQLGTLEGFIRQADNLRLQTLQQMLRVLTTRQSARALLAIHDYSSRLRALSSLWLARPRE