wanglab/gogpt-training-data huggingface dataset:
Protein: Protein daughter of sevenless (Q9VZZ9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential component for signaling from various receptor tyrosine kinases such as Sevenless, TORSO and DER. Required for photoreceptor cell and wing development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10640704}. Membrane {ECO:0000269|PubMed:10640704}; Peripheral membrane protein {ECO:0000269|PubMed:10640704}; Cytoplasmic side {ECO:0000269|PubMed:10640704}.
Interaction partners:
- Tyrosine-protein phosphatase corkscrew
- Growth factor receptor-bound protein 2
- Protein sevenless
- Epidermal growth factor receptor
- Tyrosine-protein kinase receptor torso
- Pi3K21B, isoform B
- DShc protein
- Protein vein
- Insulin receptor substrate 1
Sequence:
MDRTFYEGWLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGLRLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGAVGADENRTQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSPAIVARRNAHSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIAASTPNLMAADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADCPPVNRKLKPKVAGGLPVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLGNSATMSPATRRSSGAPLSMVLPHETDVHSPAAANAFFHETRTLPRQQHRHHPNSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKPPLLNRSSMSVGNLYSQGGNGASGMRFAGVEAGGARAPVPSSVVYRSVDFVKTEAFKRIREERESSGNK
Protein: Retinitis pigmentosa GTPase regulator (Q9GMD3)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
KQEIIEKPKQHTTYTESDDSNEYENEEISPKVTEGRVYKQLLAQGMYAMPVAISMETFSDEDVGDDSDQQSPQTSTSAEGLQKGTFRHENKHDVYPLNTEEIEKESDEGQSQKDSEANEIVSEMESDLVKMTDLKDIRKTEENRKNTDTFFDDLPNRYMNIEDEEDKDFVKESKGDKQDMIFDSEQASIEEENSYLEGESESQQSIADGFQQSESIEFNSVEKDDDEVETNQNLWYSRTFIKQRHEEARHRLSRIMAKYEFKCDRLSRIPEEQEEDSEGSGVEEQEIEANEEECGEKEKEETALLSDDLTDRAEVSEGKGKLGGEAEHVPKGGGEGIRKEGNSGVEQRSRTGSEEGEEGEDMGEGVIESLGKGEKDLEEEEQEQKEREQGHQEERSTGRKEAGEREQGGGEGEEEADEEEGEEEKDKEKEEGKEKEEEEEQEGEGEELEEGRWQDGEEGEGKGDEEGQEGGREEEGDREGQEGEEEGEGEEAGEGEEEGEGEEEGEGEEEGEGEEAGEGEEAGEGKGREEEEKGEEGEGEEKVGGEEEEDGEGQEGEEEEEEEGDGEEEEEGDGEEQEAEGGEVEGDGEVEEVGDEEKEGDGEEEGDGEREGGTGEGDEEEQKGEEEEEGDGEGEEEGDGEGEEEGDGEGEEEGDGEEQEGEKEEDGEGEEEGDGEGEEGDGEGEEEGDGEGEEEGDGEGEEEGDGEEQEGEEEEDGEGEEEGDGEQEGEEEEEGGGDEGEEEGEGEEELEEGEGEEEGEAEGEEGEGEEEEGEGEKGGEGLGGEGEEGEEEGGERVEEGEGEREREGMEREEKEWVVRKRKEKENGRGEEKEEDENNEEEKGKCQETGNEESGRQGRKGGGRESKVSKIRGSGKYGKDRTHPKKFTTNREGKGKGHGVQRFKIPVQSKQLLVNGPPGSKKFWNNVLPHYLELK
Protein: Succinate dehydrogenase subunit 6, mitochondrial (Q941A6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Succinate dehydrogenase subunit 3-1
- Succinate dehydrogenase subunit 7A
- Succinate dehydrogenase subunit 8
- Succinate dehydrogenase subunit 5
- Succinate dehydrogenase subunit 7B
- Succinate dehydrogenase subunit 4
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 3, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
Sequence:
MGDSESFVGKNWNGLKDFWSDRLSFFENYTRFTKRDAPLPSWSSSDVEEFIASDPVHGPTLKTAREAVTFGVTGAALGAVSTAAFAWKYSRSPHGAALSFLGGGVFGWTFGQEVANHTLQLYKLDTMAAQVKFMEWWERKSQ
Protein: ABC transporter, ATP-binding protein ComA (Q8DW05)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- ComB, accessory factor for ComA
- ABC transporter, ATP-binding protein
- ABC transporter, ATP-binding and permease protein
- Uncharacterized protein
Sequence:
MKQVIYVVLIVIAVNILLEIIKRVTKRGGTVSSSNPLPDGQSKLFWRRHYKLVPQIDTRDCGPAVLASVAKHYGSNYSIAYLRELSKTNKQGTTALGIVEAAKKLGFETRSIKADMTLFDYNDLTYPFIVHVIKGKRLQHYYVVYGSQNNQLIIGDPDPSVKVTRMSKERFQSEWTGLAIFLAPQPNYKPHKGEKNGLSNFFPLIFKQKALMTYIIIASLIVTLIDIVGSYYLQGILDEYIPDQLISTLGMITIGLIITYIIQQVMAFAKEYLLAVLSLRLVIDVILSYIKHIFTLPMSFFATRRTGEITSRFTDANQIIDAVASTIFSIFLDMTMVILVGGVLLAQNNNLFFLTLLSIPIYAIIIFAFLKPFEKMNHEVMESNAVVSSSIIEDINGMETIKSLTSESARYQNIDSEFVDYLEKNFKLHKYSAIQTALKSGAKLILNVVILWYGSRLVMDNKISVGQLITFNALLSYFSNPIENIINLQSKLQSARVANTRLNEVYLVESEFEKDGDLSENSFLDGDISFENLSYKYGFGRDTLSDINLSIKKGSKVSLVGASGSGKTTLAKLIVNFYEPNKGIVRINGNDLKVIDKTALRRHISYLPQQAYVFSGSIMDNLVLGAKEGTSQEDIIRACEIAEIRSDIEQMPQGYQTELSDGAGISGGQKQRIALARALLTQAPVLILDEATSSLDILTEKKIISNLLQMTEKTIIFVAHRLSISQRTDEVIVMDQGKIVEQGTHKELLAKQGFYYNLFN
Protein: Threonine dehydratase 2 biosynthetic, chloroplastic (EC 4.3.1.17) (EC 4.3.1.19) (SlTD2) (Threonine deaminase 2) [Cleaved into: Processed threonine dehydratase 2 (Processed TD2) (pTD2)] (P25306)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Not required for normal growth and development of the plant.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- ACT domain-containing protein
- ACT domain-containing protein
- Acetolactate synthase
- Acetolactate synthase
- low-specificity L-threonine aldolase
- Acetolactate synthase
- tryptophan synthase
- alanine--glyoxylate transaminase
- Uncharacterized protein
- Tryptophan synthase
Sequence:
MEFLCLAPTRSFSTNPKLTKSIPSDHTSTTSRIFTYQNMRGSTMRPLALPLKMSPIVSVPDITAPVENVPAILPKVVPGELIVNKPTGGDSDELFQYLVDILASPVYDVAIESPLELAEKLSDRLGVNFYIKREDKQRVFSFKLRGAYNMMSNLSREELDKGVITASAGNHAQGVALAGQRLNCVAKIVMPTTTPQIKIDAVRALGGDVVLYGKTFDEAQTHALELSEKDGLKYIPPFDDPGVIKGQGTIGTEINRQLKDIHAVFIPVGGGGLIAGVATFFKQIAPNTKIIGVEPYGAASMTLSLHEGHRVKLSNVDTFADGVAVALVGEYTFAKCQELIDGMVLVANDGISAAIKDVYDEGRNILETSGAVAIAGAAAYCEFYKIKNENIVAIASGANMDFSKLHKVTELAGLGSGKEALLATFMVEQQGSFKTFVGLVGSLNFTELTYRFTSERKNALILYRVNVDKESDLEKMIEDMKSSNMTTLNLSHNELVVDHLKHLVGGSANISDEIFGEFIVPEKAETLKTFLDAFSPRWNITLCRYRNQGDINASLLMGFQVPQAEMDEFKNQADKLGYPYELDNYNEAFNLVVSE
Protein: RELB proto-oncogene, NF-kB subunit (D4A8H1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a.
- Transcription factor p65
- REL proto-oncogene, NF-kB subunit
- NF-kappa-B inhibitor alpha
- NF-kappa-B inhibitor beta
- NF-kappa-B inhibitor epsilon
- Mitochondrial-processing peptidase subunit beta
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- TPX2, microtubule nucleation factor
Sequence:
MPSRRAARESAPELGALGLRLPGSSDIPSLSRTTDELEIIDEYIKENGFGLDGAQLSEMPRLVPRGPASLSSVTLGPAAPPPPATPPWNCTLGRLVSPGPCPRPYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVFSTASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKRGLPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLPPSALQSADTDFFPGTISLPGLEPPGGPDLLDDGFAYDPSAPTLFTMLDLLPPAPPLASAVVGNGGAGATVVESPGPEPLSLDSFAAPGPGDVGTASLVGSNMFPNQYREAAFGGGLLSPGPEAT
Protein: Snaclec CHH-B subunit beta (P81509)
Organism: Crotalus horridus (Timber rattlesnake)
Function: Binds to the subunit GPIbalpha (GP1BA) of the platelet GPIb/V/IX receptor system. It inhibits ristocetin- and vWF-induced platelet aggregation in platelet-rich plasma by inhibiting the binding of vWF to GPIbalpha.
Subcellular location: Secreted.
Interaction partners:
Sequence:
DCPSDWSSYEGHCYRVFQQEMTWDDAEKFCTQQHTGGHLVSFRSSEEVDFLVSILKFDLFWMGWRDIWNERRLQWSDGTKVNYKAWSAEPECIVCRATDNQWLSTSCSKTHNVVCKF
Protein: DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) (P15042)
Organism: Escherichia coli (strain K12)
Function: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Interaction partners:
- DNA ligase B] B)
- Leucine--tRNA ligase
- DNA polymerase I
- Ribosomal RNA small subunit methyltransferase B
- DNA topoisomerase 1
- Uncharacterized protein YpeB
- Beta sliding clamp
- DNA primase
- DNA helicase II
- UvrABC system protein A
Sequence:
MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKNNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDEAEMLRLLGS
Protein: Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B) (P50114)
Organism: Mus musculus (Mouse)
Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P04271}. Nucleus {ECO:0000250|UniProtKB:P04271}. Secreted {ECO:0000269|PubMed:31043739}. Note=Secretion into the medium is promoted by interaction with isoform CLSTN3beta of CLSTN3. {ECO:0000269|PubMed:31043739}.
Interaction partners:
- F-actin-capping protein subunit alpha-1
- F-actin-capping protein subunit alpha-2
- Advanced glycosylation end product-specific receptor
- Cellular tumor antigen p53
- Fibroblast growth factor 2
- Ribosomal protein S6 kinase alpha-1
- Protein S100-A1
- Glial fibrillary acidic protein
- High mobility group protein B1
- F-actin-capping protein subunit alpha
Sequence:
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVAMVTTACHEFFEHE
Protein: 8-oxo-dGTP diphosphatase (8-oxo-dGTPase) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase) (Mutator protein MutT) (dGTP pyrophosphohydrolase) (P41354)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates.
Interaction partners:
Sequence:
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAAREILEETGLKAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
Protein: PE family protein PE2 (Q79G05)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- PE family protein PE1
Sequence:
MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYADAEAAIASTRQNQLAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPLPPPSMLTPPIRCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLTILHDAIMVELATTGNAVTVFGWSQSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLTFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQVEGATKLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLTLPQIQLPQPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTVDIALALVTTLPLYTTQLFVRQLAAGNLINAIGYPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPTTVYRPRQ
Protein: Protein JAZ7 (Jasmonate ZIM domain-containing protein 7) (Pto-responsive gene 1 protein) (Q9M723)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Repressor of jasmonate responses.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9LMA8, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Transcription factor MYC1
- Protein TIFY
- Coronatine-insensitive 1
- Transcription factor MYC2
- Protein TIFY
- Protein TIFY
- Tify domain-containing protein
- Protein TIFY
- Protein TIFY
- Protein TIFY
Sequence:
MDSRMEIDFMDLNSKPKLSEMEKQHKKVSGMKWPFSLADLATHHEHTFFQNYKSTPIVSINSKNSSLNNYKSTIDPQYFRGTFPLLAKTSTYDSRKNYDNLSPNESTLTIFYMGEVHIFPGISPEKAELIIDLVSKSTTLHMDEILEKVMNKEKYEENKSDPSNASTNYAKGALAMARRATLARFLEKRKHRLIKARPYLYGENLSKFPFDIQQQEEETASSSVHWEN
Protein: Twenty-four, isoform F (Twenty-four, isoform G) (Twenty-four, isoform H) (Twenty-four, isoform K) (Twenty-four, isoform L) (Twenty-four, isoform M) (E1JJD6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLKKAEYDEEISYRAIKSCLTINPSALTSSAATGSSGGSSSSAGHNSSYNSTNHRSTDPGQRHKQGGSLQDLVEAAHRSELATTSAAAAAAATAAATQRFNCDYQLSGRSNRRQQQQQQQHNQNATSSASASKKIKNLNVSGRQREGGSLPSSVNFEPASSAMEAKQNKQQAQPSTEAAGGSFSGSVGNKHHHRSSTGSCSSLITQSRDTEANNQFDLDMDDATGVGASAVVGASGDQDDNMLEQLDPQNPSMKFLIDALNDTPLEARYTGAGKKFLIDDRLHFSVLELSARRKLQQQAQYLAALTGQFGLGLEEEKRKVEAGYVSLNDNYTACSSVYGGGAGSPAAVEGSKPSTSSSAVSGGSNCGASSDALSSDLRPAKIGRMVPAAAAVAAAPMGGKTTTRQLDENGNALGDGFGGSAASGSSGASGASAAASSSNGNGNANQFTALITPTVGSSVPTSTVAHRQNSVSTLLSTGTNTTTTAMAAAAVAASYSQLQQAPVGGAAGTVSGIGIGMQQPTKQKTKKKSQQERNTTTVDVESVAGYRGNDPVEQLVKYIENDVNGGGNSAAGQRKKERKKQNKLKKSNSLEELRTCSKMEVDDLKRQSATTEMMRHKKGTNNASSGGSSSTASGSSNSGKHNSASVADINKNCNKEQQQQSTPTVQVRNSNNPGTQQRKGERRSWGTEELQYLGDHQEISAAWSELETVGQKELPLALPALARMSELDALNTVLSETAEFHVVTKKKKPKKQRAVTMDDAAVAAAAVTGGNLQRMQQITKSASSNIMSQRMHYYTPYNSNNGGGSVNYKQQQQQSQQYQEHYQAPQGQHHHHHHHHHHHHHHHSGSAVSNQVDSSRRKSTSSMPPSEKSDSSDLDSVHSLPIQTGKKKSLGGGNNKQRGAPSASQRQAKQNNNAAAPISYADIARNKQEALNNATASDTELELGDKMQIKSGGKSKSRPDFPELPGAVTAVAASGGAANQATVVSSQNTPPSSSSSISYSQSLNATPPSSSSDAESTNSPELLAQVQIPAYSMITPTLTASMISSVSSSVASTSSTSCSPPALQKSKSVEHDTSYSCNSSNLDQQYPALEKTVKRHSTNNVSVAVAASTSASASSSLYNFAAAAKQQLTENTHSAVSPPAAVTTTSTAVAASAPAPTTVTVPAAVTVPCYSSSSTHGSTQTSTSTASSAIAALPSGKAKAKPKELSPSSSCSKKPTKPSQDVPSISLSISTTPRATTSTSTTTTQKTTAATQTEGAKKLIGGIHKLPSSSCIAKGAGAVLEATAGRRAVIILNDDREAGRSNNEFIFGDFNEDELKLFDDNLDDEEEGQHKQSSNKKQQTEGESDVTQDDTEDVDQDLDKELECLGRRPEKKQERQQDISASSDQHLNDSGAASDAVNSSASLDMLSISAEAAQSSPNAGATATSSSVASPINSSTPSGASSASASTSTSSSSVSISSSSGGNGAACLASVSGMLGGVANQSGDSGIYAAANTSIKEHVNTFLSKASSSEETLPSPNSISMQQLETCNDIEAAIIAAARAAAAARSTSCSRSNSQEQDALQPQVKTKATPNPEAKMVLPVFVTYNNNNNDDDDDEEDDESLQELSFMADLKADAATEDIAMQPPPPSCPAMMTNTELIVDYIAKTWNAIANSKYVTYYNEQEQEQET
Protein: Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) (P07861)
Organism: Rattus norvegicus (Rat)
Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of the atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P08473}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Angiotensin-converting enzyme 2
- Dipeptidyl peptidase 4
- Lysosomal Pro-X carboxypeptidase
- Angiotensinogen
- Xaa-Pro aminopeptidase 2
- Meprin A subunit beta
- Insulin-degrading enzyme
- Meprin A subunit alpha
- Angiotensin-converting enzyme
- Angiotensin-converting enzyme
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
Protein: ATP-binding cassette sub-family B member 6 (EC 7.6.2.5) (ABC-type heme transporter ABCB6) (A0A2R8RXI2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004146}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}. Endosome, multivesicular body membrane {ECO:0000256|ARBA:ARBA00004333}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004414}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}. Melanosome membrane {ECO:0000256|ARBA:ARBA00024320}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
Sequence:
MVEMKSFCEAGVSMQQVWVEGGLTLCFYFTLVPSVLLTLLFLFGTLLCIWYSRYGTDMEPKFVPRSGLYRLQVGLSVLLILQALGWMVFRLSWSAELPGYVVLYGCLSMLGWIWAVVLLRLERRKVLVRDRTRGHSTVLLLYWAVAFAADNLAFVSWMSPQWWWSLETSEQQMEFAFWLVRYFCSGLLFLLGLKAPGLPRRPYMLLVNEDERDVEHGAPLLGNSDEDQSTWKDFGKKVRLLVPYMWPKGSVLLQLLVLMCLGMLGIERAINVFVPIYYKNIVNQLTDGSSWKTLAMTVCVYCLLKFLQGGGAGASGFVSNLRSFLWIRVQQYTNRVVQVRLFAHLHALSLRWHLGRRTGDVLRSIDRGTSSINSLLSYIVFSIFPTIADIVIAIVYFISNFNAWFGLIVFVCMALYLTLTIFITEWRTKYRRDMNTQDNNAKSKAVDSLLNFETVKYYNAESYEVGRFEDAILKYQVSEWKTNASLALLNQTQNLIIGLGLLTGSLLCAYFVTEGKFQVGDYVLFGTYIIQLYTPLNWFGTYYRMIQNSFIDMESMFKLFTEEEEVKDEVNAGNLYFRQGKVEFENVFFSYTQGKEILKDVSFTVLPGQTVALVGQSGSGKSTIIRLLFRFYDVQGGCIKIDGQDISKVKQSSLRAHIGVVPQDTVLFNDNIRDNIRYGRVTATDQEVEEAAIAADIHDKIIGFPDGYETQVGERGLKLSGGEKQRVAIARTILKAPQIILLDEATSALDTQTERNIQASLAKVCANRTTVVVAHRLSTIIGADVILVLRDGQIVERGRA
Protein: Protein HEAT STRESS TOLERANT DWD 1 (Q9ZUN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable substrate receptor of CRL4 E3 ligase complexes acting as negative regulators of thermotolerance by disturbing the action of HSP90-1 and by preventing the expression of heat-inducible genes (e.g. HSP14.7, HSP21, At2g03020 and WRKY28).
Interaction partners:
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein 18 homolog
- Ribosome biogenesis protein WDR12 homolog
- F18K10.11 protein
- U3 snoRNP-associated protein-like YAO
- Notchless protein homolog
- Protein RADIALIS-like 2
- Carotenoid cleavage dioxygenase 7, chloroplastic
- U3 snoRNP-associated protein-like EMB2271
- Carotenoid cleavage dioxygenase 8, chloroplastic
Sequence:
MGRNVKTKAKRKNKKKAEASSSEIPSIPTRVWQPGVDTLEDGEELQCDPSAYNSLHGFHVGWPCLSFDILGDKLGLNRTEFPHTLYMVAGTQAEKAAHNSIGLFKITNVSGKRRDVVPKTFGNGEDEDEDDEDDSDSDDDDGDEASKTPNIQVRRVAHHGCVNRIRAMPQNSHICVSWADSGHVQVWDMSSHLNALAESETEGKDGTSPVLNQAPLVNFSGHKDEGYAIDWSPATAGRLLSGDCKSMIHLWEPASGSWAVDPIPFAGHTASVEDLQWSPAEENVFASCSVDGSVAVWDIRLGKSPALSFKAHNADVNVISWNRLASCMLASGSDDGTFSIRDLRLIKGGDAVVAHFEYHKHPITSIEWSAHEASTLAVTSGDNQLTIWDLSLEKDEEEEAEFNAQTKELVNTPQDLPPQLLFVHQGQKDLKELHWHNQIPGMIISTAGDGFNILMPYNIQNTLPSELPA
Protein: Sulfite oxidase (EC 1.8.3.1) (Moco-containing protein AtMCP) (At-SO) (AtSOX) (Q9S850)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in sulfite oxidative detoxification.
Subcellular location: Peroxisome {ECO:0000269|PubMed:11598126, ECO:0000269|PubMed:12147736}.
Interaction partners:
- Assimilatory sulfite reductase
- 5'-adenylylsulfate reductase 2, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial
- 5'-adenylylsulfate reductase 3, chloroplastic
- ATP sulfurylase 1, chloroplastic
- ATP sulfurylase 2
- Persulfide dioxygenase ETHE1 homolog, mitochondrial
- ATP-sulfurylase 3, chloroplastic
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 2
Sequence:
MPGIRGPSEYSQEPPRHPSLKVNAKEPFNAEPPRSALVSSYVTPVDLFYKRNHGPIPIVDHLQSYSVTLTGLIQNPRKLFIKDIRSLPKYNVTATLQCAGNRRTAMSKVRNVRGVGWDVSAIGNAVWGGAKLADVLELVGIPKLTASTNLGARHVEFVSVDRCKEENGGPYKASITLSQATNPEADVLLAYEMNGETLNRDHGFPLRVVVPGVIGARSVKWLDSINVIAEESQGFFMQKDYKMFPPSVNWDNINWSSRRPQMDFPVQSAICSVEDVQMVKPGKVSIKGYAVSGGGRGIERVDISLDGGKNWVEASRTQEPGKQYISEHSSSDKWAWVLFEATIDVSQTTEVIAKAVDSAANVQPENVESVWNLRGVLNTSWHRVLLRLGHSNL
Protein: Oleoyl-acyl carrier protein thioesterase 1, chloroplastic (EC 3.1.2.14) (18:0-acyl-carrier protein thioesterase) (18:0-ACP thioesterase) (Acyl-[acyl-carrier-protein] hydrolase) (Q42561)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an essential role in chain termination during de novo fatty acid synthesis. Possesses high thioesterase activity for oleoyl-ACP versus other acyl-ACPs. Substrate preference is 18:1 > 18:0 > 16:1.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 7, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic
- Long chain acyl-CoA synthetase 9, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 5, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 1, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 3, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 4, chloroplastic
- Long chain acyl-CoA synthetase 4
- Long chain acyl-CoA synthetase 1
Sequence:
MLKLSCNVTDSKLQRSLLFFSHSYRSDPVNFIRRRIVSCSQTKKTGLVPLRAVVSADQGSVVQGLATLADQLRLGSLTEDGLSYKEKFVVRSYEVGSNKTATVETIANLLQEVGCNHAQSVGFSTDGFATTTTMRKLHLIWVTARMHIEIYKYPAWGDVVEIETWCQSEGRIGTRRDWILKDSVTGEVTGRATSKWVMMNQDTRRLQKVSDDVRDEYLVFCPQEPRLAFPEENNRSLKKIPKLEDPAQYSMIGLKPRRADLDMNQHVNNVTYIGWVLESIPQEIVDTHELQVITLDYRRECQQDDVVDSLTTTTSEIGGTNGSATSGTQGHNDSQFLHLLRLSGDGQEINRGTTLWRKKPSS
Protein: Lysozyme D (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase D) (P83972)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.
Interaction partners:
Sequence:
MKAFIVLVALACAAPAFGRTMDRCSLAREMSNLGVPRDQLARWACIAEHESSYRTGVVGPENYNGSNDYGIFQINDYYWCAPPSGRFSYNECGLSCNALLTDDITHSVRCAQKVLSQQGWSAWSTWHYCSGWLPSIDDCF
Protein: Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) (P43407)
Organism: Mus musculus (Mouse)
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Fibronectin
- Glypican-1
- Ezrin
- Syndecan-1
- Syndecan-4
- Radixin
- Moesin
- Transforming growth factor beta-1 proprotein
Sequence:
MQRAWILLTLGLMACVSAETRTELTSDKDMYLDNSSIEEASGVYPIDDDDYSSASGSGADEDIESPVLTTSQLIPRIPLTSAASPKVETMTLKTQSITPAQTESPEETDKEEVDISEAEEKLGPAIKSTDVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA