wanglab/gogpt-training-data huggingface dataset:
Protein: LD27988p (Protein tyrosine phosphatase Meg2, isoform A (EC 3.1.3.-, EC 3.1.3.48)) (Q9W323)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQQTQWNKDRQEDRNNNSGSRSEQDSGCHRRLFLCIAKAVKQFIDLCNNLGANCSTTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDEREPDSE
Protein: Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (MnCaMKI) (W0LYS5)
Organism: Macrobrachium nipponense (Oriental river shrimp) (Palaemon nipponensis)
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth (By similarity). Involved in molting (Probable).
Interaction partners:
Sequence:
MPLFGSKKETAKKSSKKDKDEGKMPAVEDKYILKDLLGTGAFSQVRLAEVKEDPSRVVAIKIIDKKALKGKEDSLENEIRVLRRLQHPNIVQLMETYEDREHVYLIIELVTGGELFDRIVEKGSYTEKDASDLIRQVLEAVDYMHDQGVVHRDLKPENLLYYSPDEDSKIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVIAYILLCGYPPFYDENDANLFAQILKGEFEFDSPYWDEISESAKDFIRQLMCVDVEKRYTCKQALGHPWISGNAASTENIHSSVSEQLKKNFAKSRWRQAYHATAVIRQMRLFATKQVIVRRKLSESQ
Protein: Glutamate-pyruvate aminotransferase AlaA (EC 2.6.1.2) (P0A959)
Organism: Escherichia coli (strain K12)
Function: Involved in the biosynthesis of alanine. Catalyzes the transamination of pyruvate by glutamate, leading to the formation of L-alanine and 2-oxoglutarate. Is also able to catalyze the reverse reaction.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Valine--pyruvate aminotransferase
- Aspartate aminotransferase
- Branched-chain-amino-acid aminotransferase
- 2-isopropylmalate synthase
- Dihydroxy-acid dehydratase
- NADP-specific glutamate dehydrogenase
- Amino-acid acetyltransferase
- Alanine racemase, biosynthetic
- Alanine racemase, catabolic
- Bifunctional chorismate mutase/prephenate dehydratase
Sequence:
MSPIEKSSKLENVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLYSARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIAPLAPDLLTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLYEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDDQKMVLDFLLQEKVLLVQGTAFNWPWPDHFRIVTLPRVDDIELSLSKFARFLSGYHQL
Protein: Ensconsin, isoform I (M9PEK8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASLGGQHGNISTNPEVENTAKRPESREGSAERKDREEKLKYARDRQNEERHRKIEELRAQAEAAQRYREQKEEERRRRIEEIRTRDTEKRHQVEERKKAIFEAEKERREYILKKNQERESRIEVKKRDRNSIGFAFGSSTPRLLDVPADYGLVSPSAFWGQRRSTSISNVAGASLTRRSSERELADSGAKKRASSSTDRQDDHRRKSSSMYEVFNWGYSNDEPPKRFSLSIAGSEINIDGPANPHPPPTSKQTANAHRPTNLTTTTATSTTTAGHNNFNNNNSYRKGSRSGNATPGGHFNNSRPGSAMSTSTNMSTSGLVPRRPATAPRKPRPASIAGTGMSLEEINKLKRDQKPPVKTTAASPSAQTTPKRTANLMSTSLIVTSSSSRLSSAEKKTPSKREPPVPKAASASKALPSRTASSERISRLTKEPKTKDTSAMTRSMIVTSSSTSTITKPAPAPVAPTSAPVPEQNGVAKEVEKTTADEPVPEAEVPTEAPVVVPSVSKAEKEALNTEKTEEGARQEEEQILAVESVPEALVTSINVEEKSDEGNEKEVPKPQEQAAPKKPSRSKENSEVRELTPPEGADLMTASMMAKKITTEEEAKAALAERRRLAREEAERQAELERQRLEAERLAEIKAQEEEAERQRLFEEESTRLAEEQRRGEEERLRKAIEEAQQREEEEKRRREEEEKQRVEREEAEKKAKEEAEKQRVEVAERLKREEKEREERRKRVEAIMLRTRKGGAATTPSKDANDKAAPAATAPENNSSSNSSVTGSSNNSAEGSPSAADSTPAPTATETVQEAPNSQAMYEQSVLDKENSLINSFSTMIIDENAKNLQQVSNGKLLVDFESTNTVPAVANGNGHIENVNNKNDINLLQDVVAPVATQLIDLSIESQDLHLNNNNSLLTSTAATTTLVTADSHENKDISLL
Protein: GH14654p (Glutathione S transferase E1 (EC 2.5.1.18)) (Glutathione S-transferase) (Q7KK90)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- GH16740p
- Glutathione S transferase D9, isoform A
- Inactive glutathione S-transferase D3
- Glutathione S transferase E7
- Glutathione S-transferase S1
- Glutathione peroxidase
- Glutathione S transferase O1
- Glutathione S transferase T1
- Glutathione S transferase E9
Sequence:
MSSSGIVLYGTDLSPCVRTVKLTLKVLNLDYEYKEVNLQAGEHLSEEYVKKNPQHTVPMLDDNGTFIWDSHAIAAYLVDKYAKSDELYPKDLAKRAIVNQRLFFDASVIYASIANVSRPFWINGVTEVPQEKLDAVHQGLKLLETFLGNSPYLAGDSLTLADLSTGPTVSAVPAAVDIDPATYPKVTAWLDRLNKLPYYKEINEAPAQSYVAFLRSKWTKLGDK
Protein: Ataxin-10 (Brain protein E46) (Spinocerebellar ataxia type 10 protein homolog) (P28658)
Organism: Mus musculus (Mouse)
Function: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UBB4}. Midbody {ECO:0000250|UniProtKB:Q9UBB4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:34970537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:34970537}. Note=Localizes to the midbody during telophase. {ECO:0000250|UniProtKB:Q9UBB4}.
Interaction partners:
- IQ calmodulin-binding motif-containing protein 1
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Ataxin-7
Sequence:
MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSTHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEESQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNAERMKDLEENLNIAINVIEAHQKHPASEWPFLIISDHFLKSPELVEAMYGKLSNQERITLLDIVIAKLVGEEQLTKDDISIFVRHAELIANSFMDQCRNVLKLTSEPHTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHEVGKESTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDVIAKMEEQGLADASLLKKMGFEIEKSGDKLILKSNNDIPPP
Protein: Serine/threonine-protein kinase BRI1-like 1 (EC 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) (Q9ZWC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor with a serine/threonine-protein kinase activity. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development. Binds brassinolide. May be involved in cell growth and vascular differentiation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15486337}; Single-pass type I membrane protein {ECO:0000269|PubMed:15486337}.
Interaction partners:
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Protein OCTOPUS
- Defensin-like protein 313
- BRI1 kinase inhibitor 1
Sequence:
MKQRWLLVLILCFFTTSLVMGIHGKHLINDDFNETALLLAFKQNSVKSDPNNVLGNWKYESGRGSCSWRGVSCSDDGRIVGLDLRNSGLTGTLNLVNLTALPNLQNLYLQGNYFSSGGDSSGSDCYLQVLDLSSNSISDYSMVDYVFSKCSNLVSVNISNNKLVGKLGFAPSSLQSLTTVDLSYNILSDKIPESFISDFPASLKYLDLTHNNLSGDFSDLSFGICGNLTFFSLSQNNLSGDKFPITLPNCKFLETLNISRNNLAGKIPNGEYWGSFQNLKQLSLAHNRLSGEIPPELSLLCKTLVILDLSGNTFSGELPSQFTACVWLQNLNLGNNYLSGDFLNTVVSKITGITYLYVAYNNISGSVPISLTNCSNLRVLDLSSNGFTGNVPSGFCSLQSSPVLEKILIANNYLSGTVPMELGKCKSLKTIDLSFNELTGPIPKEIWMLPNLSDLVMWANNLTGTIPEGVCVKGGNLETLILNNNLLTGSIPESISRCTNMIWISLSSNRLTGKIPSGIGNLSKLAILQLGNNSLSGNVPRQLGNCKSLIWLDLNSNNLTGDLPGELASQAGLVMPGSVSGKQFAFVRNEGGTDCRGAGGLVEFEGIRAERLERLPMVHSCPATRIYSGMTMYTFSANGSMIYFDISYNAVSGFIPPGYGNMGYLQVLNLGHNRITGTIPDSFGGLKAIGVLDLSHNNLQGYLPGSLGSLSFLSDLDVSNNNLTGPIPFGGQLTTFPVSRYANNSGLCGVPLRPCGSAPRRPITSRIHAKKQTVATAVIAGIAFSFMCFVMLVMALYRVRKVQKKEQKREKYIESLPTSGSCSWKLSSVPEPLSINVATFEKPLRKLTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDNNLVGWAKQLYREKRGAEILDPELVTDKSGDVELFHYLKIASQCLDDRPFKRPTMIQLMAMFKEMKADTEEDESLDEFSLKETPLVEESRDKEP
Protein: Thiosulfate dehydrogenase (EC 1.8.2.2) (Tetrathionate synthase) (A4VND8)
Organism: Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri)
Function: Catalyzes the oxidation of 2 molecules of thiosulfate to tetrathionate, using TsdB as an electron acceptor.
Subcellular location: Periplasm {ECO:0000250}.
Interaction partners:
Sequence:
MNTQLLVTLLAMSIGGVALAAEIKMDDQSQLTQKAGKGAGESYFQPPQEKDLPANAYGELVQQGRAIFVDTQKYAAEYVGNGMNCTNCHLEQGRKANSAPLWGAYPMYPAYRKKNDKVNSYAERVQGCFQFSMNGTPPAADSHVINALTAYSYWLSTGAPTGQELPGRAYPEVPQPQGGFDIAKGKQIYAEQCAVCHGDDGQGQKAGGGYVFPPLWGKDSFNWGAGMHRINTAAAFIKESMPLGKGGSLSDADAWHVAAYMNSHERPQDPRLIEGSVEKTRLKYHANDGVNLYGQQVDGALLGQGVK
Protein: Growth/differentiation factor 8 (GDF-8) (Myostatin) (O14793)
Organism: Homo sapiens (Human)
Function: Acts specifically as a negative regulator of skeletal muscle growth.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O08689}.
Interaction partners:
- Follistatin
- TGF-beta receptor type-1
- Activin receptor type-2B
- Follistatin-related protein 3
- Activin receptor type-2A
- Activin receptor type-1B
- WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
- Mothers against decapentaplegic homolog 2
- Immunoglobulin lambda-like polypeptide 5
- Probable non-functional immunoglobulin heavy variable 3-16
Sequence:
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Protein: Uncharacterized protein Rv0569 (P9WM83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Oxygen sensor histidine kinase response regulator DevS/DosS
- DNA-binding transcriptional activator DevR/DosR
- Vitamin B12-dependent ribonucleoside-diphosphate reductase
- Universal stress protein Rv2005c
- Uncharacterized protein Rv1738
Sequence:
MKAKVGDWLVIKGATIDQPDHRGLIIEVRSSDGSPPYVVRWLETDHVATVIPGPDAVVVTAEEQNAADERAQHRFGAVQSAILHARGT
Protein: Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) (Q7ZVY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P00889}.
Interaction partners:
- Malate dehydrogenase
- Aconitate hydratase
- Cytoplasmic aconitate hydratase
- ATP-citrate synthase
- ATP-citrate synthase
- Acetyltransferase component of pyruvate dehydrogenase complex
- Malate dehydrogenase
- Acetyl-coenzyme A synthetase
- Acetyl-coenzyme A synthetase
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
Sequence:
MSFLSISRLAPRLLSSKNAACVVVAARNASASTNLKDVLSDLVPKEQSRIKNFKQQYGKTSIGQITVDMVYGGMRGVKGLVYETSVLDPDEGIRFRGYSIPECQQLLPKAPGGEEPLPEGLFWLLVTGQVPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQFSAAITALNSESSFARAYSEGVNKAKYWEFVYEDSMDLIAKLPCVAAKIYRNLYREGSSIGAIDSNLDWSHNFTNMLGYTEPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAAMNGLAGPLHGLANQEVLVWLTALQKELGGEVSDEKMRDYIWNTLKSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLVWSRALGFPLERPKSMSTDGLMALVGAKSG
Protein: Mitogen-activated protein kinase kinase kinase NPK1 (EC 2.7.11.25) (Nicotiana protein kinase 1) (Q40541)
Organism: Nicotiana tabacum (Common tobacco)
Function: Functions in the NACK-PQR (NPK1-NQK1/MEK1-NRK1) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion, and depends on NACK1 and NACK2 kinesin-related proteins. Functions in the regulation of resistance gene-mediated resistance responses such as the N-mediated resistance to tobamovirus (TMV) and the Rx-mediated hypersensitive response (HR) to potato virus X (PVX).
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, phragmoplast. Note=In interphase and prophase, detected in the nucleus. From prometaphase to metaphase, found in the cytoplasm in patches. At anaphase, distributed around the spindle midzone and on the phragmoplast equator at telophase and then redistributed to the newly forming daughter nuclei.
Interaction partners:
- Kinesin-like protein NACK1
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein NACK1
- Kinesin-like protein
- Kinesin-like protein NACK1
- Kinesin-like protein NACK2
Sequence:
MQDFIGSVRRSLVFKQSGDFDTGAAGVGSGFGGFVEKLGSSIRKSSIGIFSKAHVPALPSISKAELPAKARKDDTPPIRWRKGEMIGCGAFGRVYMGMNVDSGELLAIKEVSIAMNGASRERAQAHVRELEEEVNLLKNLSHPNIVRYLGTAREAGSLNILLEFVPGGSISSLLGKFGSFPESVIRMYTKQLLLGLEYLHKNGIMHRDIKGANILVDNKGCIKLADFGASKKVVELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTIIEMATGKPPWSQQYQEVAALFHIGTTKSHPPIPEHLSAESKDFLLKCLQKEPHLRHSASNLLQHPFVTAEHQEARPFLRSSFMGNPENMAAQRMDVRTSIIPDMRASCNGLKDVCGVSAVRCSTVYPENSLGKESLWKLGNSDDDMCQMDNDDFMFGASVKCSSDLHSPANYKSFNPMCEPDNDWPCKFDESPELTKSQANLHYDQATIKPTNNPIMSYKEDLAFTFPSGQSAAEDDDELTESKIRAFLDEKAMDLKKLQTPLYEGFYNSLNVSSTPSPVGTGNKENVPSNINLPPKSRSPKRMLSRRLSTAIEGACAPSPVTHSKRISNIGGLNGEAIQEAQLPRHNEWKDLLGSQREAVNSSFSERQRRWKEELDEELQRKREIMRQAVNLSPPKDPILNRCRSKSRFASPGR
Protein: Large ribosomal subunit protein mL51 (39S ribosomal protein L51, mitochondrial) (L51mt) (MRP-L51) (P0C2B6)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941}.
Interaction partners:
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL48
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein mL50
- Large ribosomal subunit protein mL55
- Ribosomal protein
- Small ribosomal subunit protein bS18m
- MRPL41 protein
Sequence:
MAGSLSWVAGRRLWGLVPLACRSFFLGVPRLFHVRVTLPPPKVIDRWNQKRAMFGVYDNIGILGNFEKHPKELIKGPVWLRGWKGNELQRCIRKKRMVGNRMFIDDLHNLNKRISFLYKRFNRHGKHR
Protein: Biklf (Klf4 protein) (Krueppel-like factor 17) (Kruppel-like factor 17) (Kruppel-like factor 4) (Q9DFS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- POU domain, class 5, transcription factor 1
- Transcription factor Sox-2
- Transcriptional regulator Myc-A
- Protein lin-28 homolog A
- Nanog
- Estrogen-related receptor beta.
- Catenin beta-1
- Neurogenic locus notch homolog protein 1
- Cellular tumor antigen p53
- Signal transducer and activator of transcription
Sequence:
MALADAMLPSINTFSNNHILDEKQSEIVRDWKVDIAKTNPRAGDVRPLIEVEFSIVESPPLAKDEDDLSKFLDLEFILSNTVTSDNDNTSAPPPAYSLPESPESCSTVYDSDGCHPTPNAYCGTNFNSRPGHSLVAELFTPDMNYQGEYNLKGHLDRLEYTELRALNTRNQQHLTNSNNAGYKIKTENQEQSCMMVNDYMGHYYAQEPQRVMQHQTYGHHVQQDVPRDILGRKDCILTEMNTQHHIDISHQQQFINNAHFPPQYAQHQQYHGHFNMFSEPLRANHPAMPGVMLTPPSSPLLGFLSPEDSKPKRGRRSWARKRTATHSCEFPGCGKTYTKSSHLKAHMRTHTGEKPYHCSWEGCGWKFARSDELTRHYRKHTGHRPFQCHLCERAFSRSDHLALHMKRHM
Protein: Flavin-dependent halogenase armH1 (EC 1.14.19.-) (G3FLZ7)
Organism: Armillaria mellea (Honey mushroom) (Agaricus melleus)
Function: Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols. The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product. The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules.
Interaction partners:
Sequence:
MEEQVPSSANILVIGGGPAGSYAATVLAREGFEVILLEKDVFPRYHIGESMLPSCRPFLKFIDCEEKLKNHGFTMKPGAAVKLNQYKREGYTDFISTNPDNAARNVVRSEFDELLLRHASEMGVHVYEGVRVEEIHFAPDEPTRPISLTWSKEDKTRGTVSFNWLVDASGRNGLMSTRYLKNRTFNKTLRNVAVWGYWTGTSCYAPGTTRENAPWFEALIDETGWAWFIPLHNGTTSVGVVLVEEESKRKKSQYRSECKDKSPSEIQHDCYMADLQRAPGLIQLLGTATFEGKLMSAGDYSYHATEYAGSNFRLAGDAGAFIDPFFSSGIHLALTGGLSAASTIAASIRGDCTESEACGFHNSKVGTAYTRFLLVVLGVYKQIRSQETAVLYDVDEDNFDKAFHFLRPVIQGCADADEGLTEAELQSTLDFCTNVFAPTQPETHEAAIQRLGSLADPDGPLLDTDTIDKLTGTDMEAKHALWKINARKPLHSMYDCKRNFGTEIINGFYVKMEQGVLGLVRT
Protein: Pleckstrin homology like domain family B member 2 (Pleckstrin homology-like domain, family B, member 2, isoform CRA_b) (G5E9V3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKVMLAQQRY
Protein: Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) (Q9BS16)
Organism: Homo sapiens (Human)
Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.
Subcellular location: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Interaction partners:
- Centromere protein M
- Centromere protein U
- Centromere protein O
- Centromere protein Q
- Centromere protein N
- Centromere protein H
- Centromere protein I
- Centromere protein L
- Centromere protein P
- Centromere protein T
Sequence:
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKEDLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTLGEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ
Protein: Glucocorticoid induced 1a (Glucocorticoid induced transcript 1) (A1L1Q3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSASPVHSARVRRSNDGSPINTSSSASSSSSSSSTGNTSRLQPIRATVPYQLLRGNQHSPTRPPASFSTPSSSSSISVGSNTEPTASAQHSNSTPGSPTLASPAGSASLDGRLIPRQRRSPPEHRSSPERCPHSPVLRAVERSKSQQVRSTGAIRRTSSLGAITGPYLIGQWPRESHLHNPLCMKDKSTQTPGCWSDESEEKRSTHQRSASWGSSDHLKEIAKLRLQLQRNKQGGGRQCKDSKECLSPLHCCTSTTTITATTISTASQAPLSMSKSAQMPLSNITVPKPSISRVPSSMEGINHELEKVFIKDNGEKEELKALEVPDGRRAPFPPQQRSSSSRGIDTQTPSVPGRSSSCSSLSPCPSPACPPRSHDGSPYSTDEMLDDRDKDSGSSSPLPKFASSPKPNNSYMFKREPPEGCEKIKVFEEMTSRQSTTVPLFSCPDKNKVNFIPTGSAFCPVKLPGSMLQHSSSQQEDEEREPTQAGPSAPHHHMPTQVSTSTSTDDPPESPSQQQEAPSESGSQPQNFEVS
Protein: Protein seele (Q7JXF7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:20970335}.
Interaction partners:
- RE51073p
Sequence:
MLTKALILFGLLALAQGYSFTSREVKCHVCKAVVTELEEAIAKEDPHKMADVSGFRLDAQGNSISKKVRLVKSEMFLTELMEKICEKMDDYLKATYKSNGKFTLLKMIINGQMNPDSSLVDFVQDGDLNKSLGHFCNEVLEDNDEIFVKAFQAEELGNDLDIKICSEQASYCDESPVQEEYDFDGKEEL
Protein: BHLH transcription factor (Oligodendrocyte transcription factor 2) (Q8QGI4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDSDTSRVSSRPSSPEGDDLFLSAVKKSVGFSGAVSSTQSDSPPELRGADMRGISSAEEDSMALKMLSKKDRKLLSENELQSMRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLSNSLEEMKRLVSEIYGGGSGAHHAGFHPSSCGTLTHAAAAPLPGHPAAVSHSSHPVHHPLLPPAVSTAASLSGTGLSAVRPHHGLLKAPSAGAGPLGAGFQHWGAGIPCPCSMCQVPPSHVPGMSAVSMPRLTSDSK
Protein: Lipopolysaccharide heptosyltransferase 1 (EC 2.4.99.23) (ADP-heptose:lipopolysaccharide heptosyltransferase I) (ADP-heptose:LPS heptosyltransferase I) (Heptosyltransferase I) (P26469)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:P24173}; Peripheral membrane protein {ECO:0000250|UniProtKB:P24173}; Cytoplasmic side {ECO:0000250|UniProtKB:P24173}.
Interaction partners:
- Lipopolysaccharide heptosyltransferase 2
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Bifunctional protein HldE
- O-antigen ligase
- Lipopolysaccharide core heptose
- Glucosyltransferase I
- Phosphoheptose isomerase
- Lipopolysaccharide heptosyltransferase 3
- D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
- NADH-quinone oxidoreductase subunit C/D
Sequence:
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIQFDWAVEEGFAQIPSWHSAVDRVIPVAIRRWRKAWFSAPIKAERTAFRRAVCANQYDAVIDAQGLVKSAALVTRLAHGIKHGMDWSTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYDKPQSQGDYAIAKHFLHCQQAVSDPYAVFLHATTRDDKHWPEANWRELIGLVGNTGLRIKLPWGAPHEEARAKRLAEGFDYVDVLPRMSLEEVARVLAGAKFVVSVDTGLSHLTAALDRPNITLYGPTDPGLIGGYGKNQMACCSPEQNLANLDATSVFGKIH
Protein: Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25] (P03230)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Inhibits also host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2. Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes.
Subcellular location: Host cell membrane {ECO:0000269|PubMed:10807912}; Multi-pass membrane protein {ECO:0000269|PubMed:10807912}.
Interaction partners:
Sequence:
MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGALCILLLMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLGATIWQLLAFFLAFFLDLILLIIALYLQQNWWTLLVDLLWLLLFLAILIWMYYHGQRHSDEHHHDDSLPHPQQATDDSGHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYD