wanglab/gogpt-training-data huggingface dataset:
Protein: Subtilisin-like protease SBT2.4 (EC 3.4.21.-) (Protein ABNORMAL LEAF SHAPE 1) (Subtilase subfamily 2 member 4) (AtSBT2.4) (F4HYR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine protease required for epidermal surface formation in embryos and juvenile plants. Involved in embryonic cuticle formation downstream of BHLH95/ZOU.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Transcription factor bHLH95
- LRR receptor-like serine/threonine-protein kinase GSO2
- LRR receptor-like serine/threonine-protein kinase GSO1
- Receptor-like serine/threonine-protein kinase ALE2
- Transmembrane protein
- Serine/threonine-protein kinase-like protein ACR4
- At3g06890
- GDSL esterase/lipase At5g03820
Sequence:
METNPRKLRSYSYICLIVCIFVLVVCAILSRAEEKEGKGENDDHIPKIYSILVEGEPLAFRASTNINSKAMALEAKKIEEIHDEILGSTLEKGSYTKLYSFKHVINAIAVRTTASQAKKLGKTKGVKAVEEDKGVKLMTTYTPDFLELPQQVWQKISNEGDRRAGEDIVIGFVDTGINPTHPSFAALDLTNPYSSNLSRLHFSGDCEIGPFFPPGSCNGKIISARFFSAGARASGALNSSLDILSPFDASGHGSHVASIAAGNAGVPVIVDGFFYGRASGMAPRSRIAVYKAIYPSIGTLVDVIAAIDQAIMDGVDVLTLSVGPDEPPVDKPTVLGIFDLAMLLARKAGVFVVQAVGNNGPSPSSVLSYSPWVVGVAAGNTDRSYPAPLILDGGQTVQGVGLSGPTLGAPLVQHRLVLAKDAVRTNGSVLQPLTRDIEECQRPENFDPAAVFGSIVICTFSDGFYNQMSTVLAITQTARTLGFMGFILIANPRFGDYVAEPVIFSAPGILIPTVSAAQIILRYYEEKTFRDTRGVATQFGARARIGEGRNSVFAGKAPVVSRFSSRGPAFIDATRSPLDVLKPDILAPGHQIWGAWSLPSAFDPILTGRSFAILSGTSMATPHIAGIGALIKQLNPSWTPAMIASAISTTANEYDSNGEIISAEYYELSRLFPSNHFDHGAGHVNPARALDPGLVLPAGFEDYISFLCSLPNISPATIRDATGVLCTTTLSHPANLNHPSVTISALKESLVVRRSFQDVSNKTETYLGSVLPPNGTTVRLTPTWFTVPPQKTQDLDIEFNVTQVLNKFTFGEVVLTGSLNHIIRIPLSVKTI
Protein: Catenin (cadherin-associated protein), delta 1 (Catenin delta-1 isoform X3) (A0A286Y8C1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
- Catenin alpha-1
- Rho-related GTP-binding protein RhoA-B
- Receptor protein-tyrosine kinase.
- Rho-related GTP-binding protein RhoA-A
- Rho-related GTP-binding protein RhoA-C
- Cell division control protein 42 homolog
- Rac family small GTPase 1b
- Rac family small GTPase 1a
- Epidermal growth factor receptor precursor.
- Rho-related GTP-binding protein RhoA-D
Sequence:
MEQCENAASLLASVREQEMQFERLTRALEEERRSVGPSGTLPRPLPTLQNGRITGDAELERLKLSEGYINGTQYRMLDPGHIVESVTVESDPHEALPIISVETGDDGTTRRTETTVKKVTKTTTTRTVIPSVSDTLSLDGTGSVTGMPSYNSPMDRVYRPPPGPMDYPTSTVPRNYHYGPPAGYDDYRSVPPSEAYTSLSRGTRMDDRYRPVDGYRTLDSAYRTHSRPQLDPYSAQPQVGRMGSAVEISALQRFVPEPYGLEDDQRSLGYDEPDYGMGPAMHYSTMPRLAHPHHAPPPRRTGSYEGTLDGDMSGAGDMFYWGGGAPLAQGERGSMASLDSTLRKGPAPTAWRQPELPEVIAMLNYRLDPVKSNAAAYLQHLTFKNDKVKSEVRRLKGIPALVSMLDNPKKEVHYAACGALKNISYGRDPDNKIAIKNCDGIPALVRLLRKTRDQDLTDTITGTLWNLSSHDSVKMEIVDHALHALSDEVMVPHSGWERGNEGGEESCKPRHLEWETALTNTTGCLRNVSSERSEARRKLRECSGLVDSLMYIVQSQINCKDVDNKLIENSVCLLRNLSYQVHREIPGCERYLESIPVNQGPLPSQKGGCFSSRKGKDEWFSKGKREDDGTSDTIDIPKRTTPAKGYELLFQPEVVRVYTSLLKESKNPSVLEAAAGAVQNLCAGRWTYGRYIRATMRQEHGLPMMTELLSHGNDRVVRAMSGALRNLAIDARNRELLGKHAVPNLVANLPGGGQSQPARALSEETVVSVLSTMAEVVGSSVDAAKTLRSAQGIERLVLINKDSNRSDREVRGAGLVLQIVWGFKELRRTLEKDGWKKTDFMVNLNPPNNTRSNGGYEESTLPLIDRGGKQDREKDMIPLNDIGPDAYSTIDQRGRRNTLDDTLDRSDRDAPQGGMYGERRGSLPLLDSYDG
Protein: Phospholipase A2, major isoenzyme (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B) (P00592)
Organism: Sus scrofa (Pig)
Function: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P04054}. Note=Secreted from pancreatic acinar cells in its inactive form. {ECO:0000250|UniProtKB:P04054}.
Interaction partners:
- Phosphatidylethanolamine N-methyltransferase
- Glycerophosphocholine cholinephosphodiesterase ENPP6
- Phosphatidylserine synthase 1.
- Cytochrome P450 2C8 isoform a
- Glycerophosphodiester phosphodiesterase domain-containing protein 1
- Phospholipase A and acyltransferase 3
- Arachidonate 5-lipoxygenase
- Cytochrome P450 family 4 subfamily A member 90
- Cytochrome P450 2E1
- Cytochrome P450 3A29
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
Protein: Leucine-rich repeat transmembrane neuronal protein 4 (Q80XG9)
Organism: Mus musculus (Mouse)
Function: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Glypican-4
- Glutamate receptor 1
- Disks large homolog 4
- Noelin-3
- Glutamate receptor 4
- Glutamate receptor 2
- Glutamate receptor 3
- Disks large homolog 3
- Protein shisa-6
- Protein shisa-9
Sequence:
MGFRLITQLKGMSVFLVLFPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNVSQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSDVQVVNTERSHLAPQTPQKPPFIPKPTIFKPDAVPATLEAVSPSPGFQIPGTDHEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEIPHHVKPLPYYSYDQPVIGYCQAHQPLHINKAYEAVSIEQDDSPSLELGRDHSFIATIARSAAPAIYLERITN
Protein: Spindle pole body protein ppc89 (Meiotically up-regulated gene 127 protein) (Q10218)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Septation initiation protein sid4
- Casein kinase I homolog hhp1
- Septation initiation network scaffold protein cdc11
- Probable E3 ubiquitin-protein ligase dma1
- Cell division control protein 31
- Spindle pole body protein pcp1
- Spindle pole body-associated protein sad1
- Protein sfi1
- Uncharacterized protein C2C4.10c
- Serine/threonine-protein kinase plo1
Sequence:
MPSQFNDNFVATDDDVGTMARVGMALDRELNGDSFQDNLNFQPRSGKREDFEPFFQDTPNTKSLSKHFHDFTMNASLETLPSVEKPRGRNMNAFEETSWNRFRKNGSLFPLSSPPISEPDLRPQALNETPDYRNRFLGAFKKQGVLDDHGNLKLDASPSFLKKPAEYTPLANRQNQNLAFDSPTEALPPKPTTPWRRNGFRSKTTPNLNSGKETPSSYKASARLMEQLGLNHSEPSVDFNNQTSYRLPNLTNLSSLIRDDTIDENGNAKEHDRLPELNTIPVASTDEQLFNAHQLLEKKFEILKRERNECNAKIDELQDKLELLTDAYNREKRRARSLEERMSKEMLTKLGESNVDDGMAASRYDTVKREKERLSEHLKSLQEQYEHIQSVYKNVLLDRESYIMRLGNKISENNELLNENRVLKEKLQTYLDKKESNVTSKIKSTAENSSKPLSMNEADERKDGLNNLLFENKSGANTKEMSNGTETAKENCSPQQDSTSPTSGYQDLVKELAKEIEMRKSLELKLKLSQSNKAGPVKHRKRRPKSKRRITGKVVFDSPNVASGVESDEGSEEISLDSEYSDILSDDGDFEKEKQATLPRRRSSSSMKGNKLAEDSYLNEAGFDWNQGTFHNGSEFGTTGVPDEPNEEELPKHVLKQVEHIINESAAHGVGKCNACHARQEDLIRGEQKVSHSNCLYADQTLRPSQPPSEALKTVVNQLTNELMELKKRYEKLSDRYNSLTPGYHKHKRQEIKNKLIKLIECMESKSDQIYLLYDVNVGKDFS
Protein: Two-component response regulator ORR3 (OsRR3) (OsRRA7) (Q6K9T0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22383541}. Nucleus {ECO:0000269|PubMed:22383541}.
Interaction partners:
Sequence:
MSTKTVPEPEPHVLAVDDSIVDRTVISRLLRSSKYRVTTVDSGKRALEVLSLDRNVHMIITDYCMPEMTGFDLLKRVKESAELKEIPVVLMSSENSPTRIRRCLEEGAEDFLIKPVRPSDVSRLCNRVIMK
Protein: Suppressor of cytokine signaling 7 (A0A5F9YLF9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQEAELRDGEAAAAAASYRVLSRLLGYGEAAPEPGPPPPPPGHGPPPPPFLARPGPRGSRPPQLMVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST
Protein: Zinc finger CCCH domain-containing protein 24 (AtC3H24) (EC 2.1.1.-) (Q8L7S3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- tRNA wybutosine-synthesizing protein 2/3/4
- Oxysterol-binding protein-related protein 1D
- AT3g17020/K14A17_14
- Ribosome biogenesis protein BOP1 homolog
- Protein TORMOZ EMBRYO DEFECTIVE
- tRNA
- MAG2-interacting protein 2
- 65-kDa microtubule-associated protein 6
- Filament-like plant protein 4
- Chaperonin 60 subunit alpha 2, chloroplastic
Sequence:
METSSIEINELPLATKTQTPPASVEPIPMETSSIDELPSSDSNATDNIEAVGEKRKRADEDEKTNLESSDTKITTPSPWWKTSLCSYFRREASCSHGNECKYAHGEAELRMKPDNTWDPTSERGKKAKAMKMSEHEEKEEDEVLFTEQMMESIDGDEGGGGSVSVVDLSLSKCLVHLPNKWQSDELKKFLGEQGVLYKSAKKRRGMIVGFVTFENAEQLQSGVEILDGKTVNSSNLKIADVLPRTFDKNDARKSVKSARDAVTPLAYLSYADQLEQKKTSIGQMLKKLARNARKACPNGNSLPQWVLTSRDRGGLACNLEGIIESPITNGYRNKCEFSVGLSLQGKPTVGFSLGSFCAGVTAVEEPVDCPNVSKIASQYASIFQKFIENSKFQVWNRFQHSGFWRQLTVREGRKPGVFSNDEDAITRIAEVMLMVQVCLTGSDEAEVATEFEELAKAFAEGARASSPTLPLTVLVVQNHSGISNVAPPDAPLQVLAIPISDNGTDQEQTTNVLTEARIHDHINNLRFSISPTAFFQVNTVTAEKLYSIAGDWADLGPDTLLFDVCCGTGTIGLTLAHRVGMVIGIEMNASAVADAERNATINGISNCKFICSKAEDVMSSLLKQYLDVTQMEEAKPLSNANDDLNKQIPSTEEMTNSEHVADQNLPPSNTQVEELQDNEQKDSSSLEPEKTTKPQFKNVVAIVDPPRSGLHPAVIKALRTHPRLKRLVYISCNPETLVANAIELCTPSFDEPDRGNKNYRGRKKIGIAALARHRAKSMPTSEAFRPVKAMAVDLFPHTDHCEMVMLLER
Protein: Erythrocyte membrane protein 1, PfEMP1 (Q8I521)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MVRSSSRASRPKYYQATSAKELLDQIGQSVHAEVQRDAKKYVSELKGNLSRATYPKDESPKGTTSPDPCHLDYRYHTNVTKGHGKEYPCEDRPEVRFSDTEGAQCDKSKIKDNKGKSEGACAPYRRSSLCDHHLSYMNAGKTNTTDNLLLEVCMAAQYEGQSIRGQHDKHKLDNNNSSSQLCTVLARSFADIGDIIRGRDLYRRDKGEETKLEKNLKEIFKNIYNELTTKNGTKERYNDTDNYFQLREDWWEENRETVWKAITCHVVSGNNYFRHTCSDENHPTATQGNCRCIGATVPTYFDYVPQYLRWFEEWAEDFCRKKKKKLPNVKTNCRGENNKKYCSGDGFDCTKTIRAKYIYAIGDECTKCSFWCGFYKKWLENQKQEFLKQKKKYETEISGGGGRKKRAARSSGSNSNYDGYESKFYNILKGIPEGGLDKFLDLLNKEEVCTKFSEDEGTIDFTKHDNKNNDQKGTFYYSKYCEICPECGVRKGTFEEKPKNESGECDGKKLYTITDYAESTDINVLSFGDERDQIKKKIDEFCDKNDINKQELTEQWKCYEEQDIENDGQDDYKDDVNGSGGICILEKTNGDKNGKKQKTFNDFFHFWVRHLLNDSIEWRDKLKKCIEDPEKKCKNGCNKKCECYERWVDKKKGEWKNIKDHFDKQPGFDQTFPPYYVLEDVLEESYFPIIQEAYGDSTAIQGIKKTLEKKKKEKGANISEEKTILDEFLNHELKDAETCKNCEPRKFKNPCSGDTSGDSNKQYEAVANTVAQILQGKAQKQLHGNGSRNALKGNIQNAKINNGRKPNPLTDACQITKNHSNGKGDSNNPCNNKGNRLKIGQVWSIKNDTSYTDVYMPPRRQHMCTSNLEKLNYASVIGSNNVNDKFLVEVLHAAKSEAEFIKKKYNEKQNDGKNGLRKDQATTCRAIRYSFADIGDIIRGKDLWDDNNDAKSLQTNLKAIFKKIKEKHPGIEGNDKYVKDNENKQLRSDWWEANRRQVWNAMTCETPNGDNIKCDVHDVPVDDYIPQRLRWMTEWAEWFCKAQSQEYDKLFMQCAKCMGNGQGCTKDSSDGECEKCKEACTSYANFINTWKPQWVPMQIQYALLYSYVGKSGTIGLGGYPDYKQVVHFFEELQKEYENATRSSSTTKVSSTASPITPYSSPEGYIHQELPITGCQKQKEFCYYKNGLTSRSSDAKENKNYAFKNPPHGYDLACTCNTRDQQTDGRGRVAVNPDDNIITPGRIDNGEDDEESDEEDFEEEELENDDAGGGSDVGEEEDVSNHQEDKGPQKEDTPQIDVCAIVKTALTTPGNLTQACKQKYGPKAPTGWKCVPSGDSTTTGEARARRVARSAEPRGSEPTSDKGSICVPPRRRKLYLGGFKRLTDGTAVSSETTSATSSHASNGDALLTAFVESASVETFFAWHKYKMEKKQPAQEGAGLGLSLLEQEVSPEDDPEKQLQTGTIPPDFLRLMFYTLGDYRDILDGKNMEVVNLLKDGSPSDKEMYTRENKINQAIDNHFSKNENQATTGVNQSSSGGVPSSSGHSSSSTVTPPGPPQTSGTTPKTWWQKNGEHIWNGMICALTYEDNGAKGTSNALQQNEEVKKALWDETTKKPKDEKYQYDQVKLDENSVTDGPRTTSPGTSGDTPPTLSQFISRPPYFRYLEEWGETFCRQRTRMLKNVKDNCTKDDKQKYSGDGEECEKVLVEEANTFKDLEGRSCADSCRSYKKWIGRKKDEYDEQESAYGQQQKEYVNGSKGAGRNNDDKEFCTKLEKTWTTAGDFLKSLGPCKNNDNGEGTIKFNGGQTFQHTNLCDSCSEFKIKCENGVCSGDTKVECNGKTPIAATEIAKMITSTEGVFMTVSDNSDHKFDDGLKDCQHAGIFKGIRKDVWTCGNVCGYVVCKPKEGNRETASGENKDQIITIRALVTHWVQNFLEDYKKIKHKFLNCTKNGQSKCINGCNNKCTCVETWISTKKGEWKNIKERFIEQYKGEPSDEYFNVRSCLETFIPQIPVADVKNEVIKLSQFDNSCGCSFSAHKQKDSNQDSIECMIKNLEKKIDECKTQHYPSGKPEEQCKEPPPEDDYEDENEKKVESPTICPKETVDQKTKVEDEKCDKTRPVVPKEDRQEEEESKKKKDETALPPPEPPADSPPPAAPTKPLPSDNTSDILKTTIPFGIALALTSIALLFLKKKTKSSVGNLFQILQIPKSDYDIPTPKSSNRYIPYVSDTYKGKTYIYMEGDSSGEEKYAFMSDTTDVTSSESEYEELDINEIYPYQSPKYKTLIEVVLEPSGKNTTASGNNTTASGKNTPSDTQNDIQNDGIPSDTPNTPSDIPKTPSDTPPPITDEEWNQLKHDFISNMLQNTQNTEPNMLGYNVDNNTHPTPSRHTLDQKPFITSIHDRNLYTGEEYNYNVNMSTNSMDDTKYVSNNVYSGIDLINDSLNSGNQPIDIYDELLKRKENELFGTNHPKHTNTHNVTKSSNSDPIDNQLDLFHTWLDRHRDMCEKLKNDNERLAKLKEEWENETHSGNTHPSDSNKTLNTDVSIQIHMDNPKPINEFTYVDSNPNQVDDTYVDSNPDNSSMDTILEDLEKYNEPYYYDMYDDDIYYDVNDHDASTVDSNNMDVPSKVQIEMDVNTKLVKEKYPIADVWDI
Protein: Acyl-CoA synthetase family member 3 (H0YGC7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLLCPLWVGATCVMMPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERYGMTEIGMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKGPSPCCCPDMPLLGFLPLPCWY
Protein: T-box transcription factor T (Brachyury protein) (Protein T) (D4A4W8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MSSPGTESAGKSLQYRVDHLLSAVESELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNDHKDVMEEPGDCQQPGYSQSGGWLVPGAGTLCPPASSHPQFGGSLSLPSTHGCERYPTLRNHRSSPYPSPYAHRNNSPTYADNSSACLSMLQSHDNWSSLGVPAHTSMLPVSHNASPPTGSSQYPSLWSVSNGTITPGSQTAGVSNGLGAQFFRGSPAHYAPLTHTVSAATSSSSGSPMYEGAATVTDISDSQYDTAQSLLIASWTPVSPPSL
Protein: Possible oxidoreductase (P71701)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Esterase Rv0045c
- F420-dependent glucose-6-phosphate dehydrogenase
- Inositol-3-phosphate synthase
- Deazaflavin-dependent nitroreductase
- Putative F420H
- F420H
- Uncharacterized HTH-type transcriptional regulator Rv0043c
- F420-dependent hydroxymycolic acid dehydrogenase
- F420H
- Phosphoenolpyruvate transferase
Sequence:
MTSLVRPDLPVRIGVQLQPQHAPHYRAVRDAVRRCEDIGVDIAFTWDHFFPLYGDPDGPHFECWTVLGAWAEQTSHIEIGALVTCNSYRNPELLADMARTVDHISGGRLILGIGSGWKQKDYDEYGYRFGTAGSRLDDLAAALPRIKARLGKLNPPPTRDIPVLIGGGGERKTLRLVAEYADIWHSFTAGDSYLAKSAVLSTHCSTVGRNPATIERSAAVDGGGLIASAEALAGLGVTLLTVGCDGPDYDLSAAAALCRWRDGR
Protein: peptidyl-tRNA hydrolase (EC 3.1.1.29) (F4JV77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MWPSSRNSSQPQAMRQEKKSISVSFRAENLIPGVVIGFIIGMILDLSQQVTSPVKRSRLLSSKVQKQSSVPGNGKDQELKMVLVVRQDLKMRTGKIASQCAHAATGMYAELMQSDRYLLRRWEENGQPKIVVTCKNQQEMNKITEAAESVGLPTFVVADAGRTEVAAGSRTVLAVGPGPKELVDSITGRLALL
Protein: glutathione-specific gamma-glutamylcyclotransferase (EC 4.3.2.7) (Q9GZE8)
Organism: Caenorhabditis elegans
Interaction partners:
- Glutathione S-transferase omega
- 5-oxoprolinase
- gamma-glutamylcyclotransferase
- Thioredoxin domain-containing protein
- Glutathione synthetase
- Gamma-glutamyltranspeptidase 1
- Gamma-glutamyltranspeptidase 1
- Gamma-glutamyltranspeptidase 1
- Putative aminopeptidase W07G4.4
- Gamma-glutamyltranspeptidase 1
Sequence:
MPLKSKILWNIAHVPRPRIVKKPPPPPPWPVTTYPAKMEALATSSTSQSLWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEETNSYTNGVVFRVDGKSAIATAVKYLEQRECDNGYAFRMVPVQIRSAAHRRPTVVMALTCVADQQNELYLGPDDLIKMAREIVTAKGCAGPNCEYVLNLAENLRKLFPNDEDDHLFQLEHHVRIAKVRA
Protein: TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) (Q53T94)
Organism: Homo sapiens (Human)
Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
Subcellular location: Nucleus, nucleolus {ECO:0000305|PubMed:11250903, ECO:0000305|PubMed:11283244}.
Interaction partners:
- TATA box-binding protein-associated factor RNA polymerase I subunit A
- TATA box-binding protein-associated factor RNA polymerase I subunit C
- TATA box-binding protein-associated factor RNA polymerase I subunit D
- TATA-box-binding protein
- RNA polymerase I-specific transcription initiation factor RRN3
- Nucleolar transcription factor 1
- Nucleolar complex protein 2 homolog
- DNA-directed RNA polymerase I subunit RPA34
- THAP domain-containing protein 7
- Single-strand DNA endonuclease ASTE1
Sequence:
MDLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTERYQEVTNTDLIPNTQIKALNRGLKKKNNTEKGWDWYVCEGFQYILYQQAEALKNLGVGPELKNDVLHNFWKRYLQKSKQAYCKNPVYTTGRKPTVLEDNLSHSDWASEPELLSDVSCPPFLESGAESQSDIHTRKPFPVSKASQSETSVCSGSLDGVEYSQRKEKGIVKMTMPQTLAFCYLSLLWQREAITLSDLLRFVEEDHIPYINAFQHFPEQMKLYGRDRGIFGIESWPDYEDIYKKTVEVGTFLDLPRFPDITEDCYLHPNILCMKYLMEVNLPDEMHSLTCHVVKMTGMGEVDFLTFDPIAKMAKTVKYDVQAVAIIVVVLKLLFLLDDSFEWSLSNLAEKHNEKNKKDKPWFDFRKWYQIMKKAFDEKKQKWEEARAKYLWKSEKPLYYSFVDKPVAYKKREMVVNLQKQFSTLVESTATAGKKSPSSFQFNWTEEDTDRTCFHGHSLQGVLKEKGQSLLTKNSLYWLSTQKFCRCYCTHVTTYEESNYSLSYQFILNLFSFLLRIKTSLLHEEVSLVEKKLFEKKYSVKRKKSRSKKVRRH
Protein: Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) (O15304)
Organism: Homo sapiens (Human)
Function: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15034012}. Nucleus {ECO:0000269|PubMed:15034012}. Note=In the nucleus, accumulates in dot-like structures.
Interaction partners:
- Bcl-2-like protein 1
- CD27 antigen
- Apoptosis regulator Bcl-2
- E3 ubiquitin-protein ligase RAD18
- Proliferating cell nuclear antigen
- Tumor necrosis factor receptor superfamily member 18
- E3 ubiquitin-protein ligase XIAP
Sequence:
MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET
Protein: Photosystem II protein PSBS2 (Protein PHOTOSYSTEM II SUBUNIT S2) (A8HPM5)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Required for non-photochemical quenching (NPQ), a mechanism that converts and dissipates the harmful excess absorbed light energy into heat and protect the photosynthetic apparatus from photo-oxidative damage. Seems involved in the activation of NPQ, possibly by promoting conformational changes required for activation of LHCSR3-dependent quenching in the antenna of photosystem II (PSII).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Photosystem II protein PSBS1
- Light-harvesting complex stress-related protein 3.1, chloroplastic
- Chlorophyll a-b binding protein
- Light-harvesting complex stress-related protein 3.2, chloroplastic
- Chlorophyll a-b binding protein
- Chlorophyll a-b binding protein
- Light-harvesting complex stress-related protein 1, chloroplastic
- Photosystem II protein D1
- Chlorophyll a-b binding protein
- Photosystem I reaction center subunit V, chloroplastic
Sequence:
MAMTLSTKAFAQRGVSARKNTVRVYAATTKVNPKLASKTEVERFKQATGLPAPAINGKQFPLKLGFTKTNELFVGRLAMVGFSASLIGEILTGKGALAQFGYETGLNGIEVDGLVIGLIAFNLIAAVLPTSQTFVPEEQDTISERPAGPLQDPRITLLEPKKFFGVQGFGFTKENELFVGRAAQLGFAFSLIGEAVTGKGALAQFDIETGLSLRDTEFGLVVFILFLLFAAINEGSGKFVDEESA
Protein: Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma) (P78395)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923, ECO:0000305|PubMed:16620968}. Chromosome {ECO:0000269|PubMed:21822215}. Cytoplasm {ECO:0000269|PubMed:23460923}. Golgi apparatus {ECO:0000269|PubMed:23460923}. Cell membrane {ECO:0000269|PubMed:16620968}. Note=Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923). {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923}.
Interaction partners:
- Cullin-2
- E3 ubiquitin-protein ligase RBX1
- Elongin-B
- Kelch domain-containing protein 3
- Kelch domain-containing protein 2
- Amyloid protein-binding protein 2
- Protein zyg-11 homolog B
- Protein fem-1 homolog C
- Protein fem-1 homolog B
- Protein zer-1 homolog
Sequence:
MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVLYPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEPILCPCFMPN
Protein: WD repeat-containing protein 38 (Q9D994)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEWAPMNIRAPTRLAVGRVRFYGQHHGEVNCSAFSPDGRTLLTASDDGCVYVWGTKSGRLLWRLAGHRGPVKSCCFSPDGRLIASSSSDHSIRLWDVARSKCLHVLKGHQRSVETVSFSPDSKQLASGGWDKRAIVWEVQSGRRVHLLVGHCDSIQSSDFSPTSDSLATGSWDSTVHIWDLRASTPVVSYHNLEGHTGNISCLCYSASGLLASGSWDKTICVWKPTTNNLPLQLKGHTIWVNSLAFSPDELKLASAGYSRTVKVWDCLTGKCLETLKGMLDVAHACIFTPDGKLLVSGAAVTR