wanglab/gogpt-training-data huggingface dataset:
Protein: GH19118p (Q961K4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Uncharacterized protein, isoform A
- GEO12018p1
- Uncharacterized protein, isoform A
- GEO11681p1
- LD42267p
- Aminopeptidase
Sequence:
MQNDKYPAPIGFYPPQGQPGYPQPASQPGYPQPGQPQHITPAETYGPQPPPMPPRDPHTRVDPPGGCFQRNQKNKPQSNAVGAAGLIFISGGMNIAWAIGFQGPIYYQTTKHNYIAWFIGAIIGALVTMALTNKVAKKYILQFSSVLVTVGGLVIACTHNNGAGTTAACYLDGIANGLVFAPFMALVGEISVPYLRGKASATLEQLCFGTGILLQILYVSNWTYSSYMTYNDFTSENMKGVLSTIYGVLALIMGSFFTIESPVLMLANNEEQAAIDALRRLQKPAVLTEETYELLAEHKRYLAYNKNMSKSESISKALPTFMRLAYLRALNAMSISSFVIITYVVAILVSNDLRNASSWYIGLAFCRWLGSLIPSFCMESLGRKKPAVFGLLVSCGLSFAVGSQYNVYTYMSQVTVLIMIFEFFAGMAFSSNSAYLTEAYPMGVKQHFIGLTFITEIFVFLIINVCDFNFGQGYNYFYIMGAMYLAGVILGVLTLPETRRMTLQGAQEQFNKFVNFRF
Protein: ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b) (P27181)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01398}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01398}.
Interaction partners:
- ATP synthase gamma chain
- ATP synthase subunit delta
- ATP synthase epsilon chain
- ATP synthase subunit beta
- ATP synthase subunit alpha
- ATP synthase subunit c
- ATP synthase subunit a
- ATP synthase subunit b'
- ATP synthase protein I
- Inorganic pyrophosphatase
Sequence:
MLNTLFILAAEAHEAGEGGFGINLDFLEANLFNLAILLGIIIYYAPKTLGKILGDRRQKIADAIEEAETRQRKSAQILAEEEKKLAQAKAEAARIVQEAGQRAEVAKQEIATQTEADLRRMQEAAAQDLGAEQERVIAELKRRIAEQAVAKAEADLRDRLNEDTQDRLIERSIAQLGGR
Protein: FMR1 autosomal homolog 1 (cDNA FLJ58644, highly similar to Fragile X mental retardation syndrome-related protein 1) (B4DXZ6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000256|ARBA:ARBA00004331}. Postsynapse {ECO:0000256|ARBA:ARBA00034110}.
Interaction partners:
Sequence:
MVTEGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS
Protein: Peroxin 11c, isoform B (A0A0B4K701)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Interaction partners:
- Peroxin 11
- Peroxin-19
- FI14123p
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- RING-type E3 ubiquitin transferase
- Peroxin-7
- Peroxisomal membrane protein PEX16
- Peroxisomal ATPase PEX6
- Peroxisomal targeting signal 1 receptor
Sequence:
MLNTIAGKPLSRYQIKRIIRYERKVMKALCYSAKLVAGYHAKRNPELAKRYATASSRISGARATLRLIDDIPMIQYALEYGLGENEPDRVMQVLGVTANIVDLLYYPIEKVCWLAEHKIVDVKNADNWDNVNSIFWVLSVYLNLMRTMRNFSLNQEKLNRTNNINELDVKTLTKHRLEMVSIVRISLDFVHAVSTLPKGYLWGGKLSTLQVGAIGTLSAGLGIYQIFAKRRLNK
Protein: Iron-sulfur cluster transfer protein NUBPL (IND1 homolog) (Nucleotide-binding protein-like) (huInd1) (Q8TB37)
Organism: Homo sapiens (Human)
Function: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19752196}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 2
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- FAD-dependent oxidoreductase domain-containing protein 1
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 4
Sequence:
MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSPSE
Protein: Uncharacterized RNA-binding protein C4F6.14 (O74400)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- ATP-dependent RNA helicase mak5
- Probable rRNA-processing protein ebp2
- ATP-dependent RNA helicase drs1
- mRNA export factor elf1
- Uncharacterized RNA-binding protein C1827.05c
- Uncharacterized protein C4F10.09c
- 25S rRNA
- Uncharacterized AAA domain-containing protein C16E9.10c
- Pumilio homology domain family member 6
- Probable nucleolar GTP-binding protein 1
Sequence:
MNSNSTLFVRNLAFQTKQDDLTNFFSDVGPIKHAVVVTNPETGENRGYGFVTFSMLEDAQRAAKELKNKKLHGRILRLDFATPRKRSEVDTDQNKAVKKTIRQDNRPRLIIRNLPWSIKKPQHLEPHFSKFGKVREIKIPTKGGGRMCGFAFVWMKDRKAAEEAMNSLNGTEIDGRPIAVDWAVSKDAFEATTLKDASSEEENKEFVSDEGHSIVTEDASADSESEEEVDGHSEGKELAGESEEEGSNVDDVEDSGDSSSDKNSINHEIRDNEGLEDTVFVRNLLFECTEQELYNHFRQFGPLAYAKLVKDPATDRSLGRGFIKFRYEKDCQNCLEMASQLPTQEPTEAEKRFLPSVLVDEGIDTDSVSSRFLLHGRLLKVTSAVTRKEASDINQKSLQERKQKMGKGVDRRHLFLLNEGKIAADHPLFNSLSETDKTLRSQSIAQRKKLLEKNPTLHLSLNRLSIRNISRHIDPKILAMLGRQAIRGFMDDVSKGLRANITEEEENLDKGHRLKRGKSGGVLKQAKVETEKAGAGRSKGFGFMQFISHKYALMALRWLNGREITVKKIIDAEIEWARKHKIPEPQLPNIDYNDRPRRLIVEFAIENIQVVKRRQEKEKSFRQKAKQLKQQEDEDNLKRKRSESDVEDNEAKEKQAKVARIIQRKRMKRRSRKN
Protein: Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (Q2KMM4)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O75342}.
Interaction partners:
- Phospholipase A2
- Phospholipase A2
- Phospholipase A2
- Phospholipase A2
- Phospholipase A2 group IVC
- Cytosolic phospholipase A2
- Prostaglandin G/H synthase 2
- Polyunsaturated fatty acid
- Phospholipase A2, group III
- Polyunsaturated fatty acid lipoxygenase ALOX15
Sequence:
MATYKVKVATGTDFFSGTLDSISLTIVGTQGESHKQRLNHFGRDFATGAVDDYTVQCQQDLGELIIIRLHKEPHSFLPKDPWYCNYVQICAPNCRVYHFPAYQWMDGYETLSLREATGKTTADDTLPILLEHRQEEIRAKKDFYHWRVFVPGLPNYVDIPSYHPPPRRCRNPNRPEWNGYIPGFPILINIKATRFLNLNLRFSFVKTASFFYRLGPMALAFKLRGLVDRKRSWKRLKDIKNIFPATKTVVSEYVAEHWTEDSFFGYQYLNGINPGHIRRCMQIPDKFPVTDEMVAPFLGEGTCLQAELEKGNIYLADYRILDGIPTVELNGQKQHHCAPICLLHFGPDGNMMPIAIQLSQTPGPDCPIFLPNDSEWDWLLAKTWVRYAEFYSHEAVAHLLESHLIGEAFCLALLRNLPMCHPLYKLLIPHTRYNVQINSIGRALLLNKGGLSARAMSLGLEGFAQVMVRGLSELTYKSLCIPNDFVERGVQDLPGYYFRDDSLAVWYAMERYVTEIITYYYPNDAAVEGDPELQCWVQEIFKECLLERESSGFPTCLRTVPELIEYVTMVMYTCSARHAAVNTGQLEYTSWMPNFPSSMRNPPMQSKGLTTLQTFMDTLPDVKTTCIVLLVLWTLCREPDDRRPLGHFPDIHFVEEAPRRSMEAFRQNLNQISHNIRQRNKCLNLPYYYLDPVLIENSISI
Protein: Transmembrane GTPase fzo-1 (EC 3.6.5.-) (Q23424)
Organism: Caenorhabditis elegans
Function: Probable transmembrane GTPase (By similarity). Mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IWA4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IWA4}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Serine/threonine-protein kinase pink-1, mitochondrial
- Apoptosis regulator ced-9
- Mitochondrial Rho GTPase 1
- Probable voltage-dependent anion-selective channel
- Dynamin-like GTPase OPA1, mitochondrial
- Dynamin-1-like protein drp-1
- FIS1-related protein fis-1
- Dynamin
- FIS1-related protein fis-2
Sequence:
MSGTASLVHTLPASGDSNHRGLHSLKNSRRAADNEPLLRFREAKKVLGDVYGELKDNVAELEGVYKDIKENDFVSSEQREEIEAIGDSIKTIMDTFQRDNMKVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTTCCFLQVEGSEGEVGHLQLDDNPQKIDMKMLGKIGHALSDENSDLPAMGQDSLLKVFHPKKSESGECRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFVLVSNAESTLTQAEKNFFLRVAKKLSKPNVFILNNRWDASAAETENIEDVKKQHLTRFRQFLVDELEVCSEREVNDRIFFVSSREVLESRLKARGLVQKAYQAEGHGTRALEFQNFERHFEHCISRSAIHTKFEAHNRRAHEMIGKMRLNLNSVLTSAAEQRSKLQNNLNESTRTFNECRVNFTQFEKAYREQTEQLRAEVHLKVSADFFEEIARLDAIIDRFEQPFDGSSSGMTKYKEDLAIFVDKCLSSDLEARCTGGLMSRIWNLENDMFQYVTKILAEPYQNKLEEVWRYRAPFKFSICVDVPALVNDFHEDLEFRFTFGLHAIIRRIIAYRSGQPVTAINTNLLTPLSLKQQSEKNSVRDAEASAASEEQAMMTQMVLTSAAFLANGSLGVLVVGGIVYKAVGWRVIAVGGAAYAGLYAWERMRWNSGAKEQHLKEQFRSHLAARMQQVSTAHTHHCETQAIREMDQVFDGLKATVGGVHREMKNDLDVQKTQIDAVDSTIRTLGTIKGKAVFLLRNLEQFASSYLRSDSPPTP
Protein: MORN repeat-containing protein 1 (Q587D3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIYSGEIENGQMHGRGCLQYPNKEKYDGDWVFGKRHGTGVYVYADGSRYEGEWVDDKVHGNGACYYTSGNVYTGEWSMGRINGRGVLEYHDGDRYEGEWKDGRMHGKGTYCYSNGDKYEGEWKEDKRHGKGVVVYAAPDGCVSEKYDGEWNEGRMQGWGKYFYADGGVYEGEWVDGRMHGRGTYVFPNGNKYEGEWVEDRKDGYGILLYTNGERYEGYWHLDKAHGKGTLTFLQGDRYVGEWHYGKKHGHGVLSYSNGDTYDGEWRDDDAWGYGVLQYANGCRYEGEWAEDRRHGKGLLVLPDGSSYEGSFAHGKKDGPGKIILKDGSMYIGTWKDGVIVGQGEFRLSENCDLSNPDY
Protein: UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) (P0A749)
Organism: Escherichia coli (strain K12)
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Target for the antibiotic fosfomycin.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00111, ECO:0000305}.
Interaction partners:
- UDP-N-acetylenolpyruvoylglucosamine reductase
- Bifunctional protein GlmU
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- UDP-N-acetylmuramate--L-alanine ligase
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Probable peptidoglycan glycosyltransferase FtsW
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- UDP-N-acetylglucosamine 2-epimerase
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
Protein: At4g05400 (Copper ion binding protein) (Q9M0V5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL21m
- Ribosomal protein L18e/L15 superfamily protein
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL9c
- Large ribosomal subunit protein mL43
- Uncharacterized protein
- 50S ribosomal protein L24
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL30m
Sequence:
MIRVTKPKAIIESLSYHLIQRCSASGTPKGKAKLKTGQPLKRNKLSIKKGGGGGGAPVEGEEAVKGKGRISDEKQKLYEQCLNAPCPVRYLTPQEIEREAQREKLGLISKEKQRDMEIQKKGGAASMGVTDEPMRIGTPGLDYISLGIFEAEELPKYKLTEEDGERLAKEYSKVLMREHRERRAAETALLNLKKSAIEALPENLKKAALEPDLTPFPANRGMATLTPPIEGYLEKVMDAAKKSSSKEKLR
Protein: ElaC ribonuclease Z 2 (H7C2I4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREVLQILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKADAPVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNI
Protein: Insulin-like growth factor 2 (Insulin-like growth factor II) (IGF-II) (Somatomedin-A) [Cleaved into: Preptin] (Q08279)
Organism: Cavia porcellus (Guinea pig)
Function: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and metabolism via increasing the mitochondrial respiration rate (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01344, ECO:0000250|UniProtKB:P09535}.
Interaction partners:
- Tyrosine-protein kinase receptor
- Cation-independent mannose-6-phosphate receptor
- Tyrosine-protein kinase receptor
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor-binding protein 1
- Glypican-3
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor-binding protein 6
- Insulin-degrading enzyme
- Insulin-like growth factor-binding protein 5
Sequence:
MGISMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSASLAVLPDNFPRYPVGKFFQYDTWRQSTQRLRR
Protein: CG1600-PA (Death resistor Adh domain containing target, isoform A) (Death resistor Adh domain containing target, isoform B (EC 1.1.1.-, EC 1.1.1.2)) (Death resistor Adh domain containing target, isoform D) (Q0E9G4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNKLCRQVSIESPGPGAKNCVFNFFVPIEDTPALGARIRIVCAGACYRRRDRANSITSMSSVSSELSDYCPSVNSMSSPAHQGIREGSFFPGFEVAGVIESLGSEITEANNRGLRIGQRVIVYPFDETPAGYAELLVVPDLKHVVPIPDSLPMEVAAMLPTGALLAWNAVFKAQAVVTQILSQRAATEPKRKPKILIVGTGGLALWAVRIASYHFATTGADNVDITVASLRDEGFRLATEIKNVSVVQWNECLYEPQLIERTKDVCGGAVDVVIDFGTTSRSLHRSMHCLSKGGVVLISDEVAEKLLPKFSRLSEQYQQEIIAISNGTAEQLAELVELVANKKIEPPPHSVFPCEQAAEVIAKLCNSEIPGRAILRFHDIE
Protein: Chloride channel protein (F6ZKG1)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004155}. Membrane {ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361221}.
Interaction partners:
Sequence:
MESEQLFQRSYYRNSYNSITSASSDEELLDGAGGMMDFHTLEDDNLLDGDASVGTHYTMTNGGAINSTTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWELAKSLYDAWSGWLVVTLTGLASGALAGFIDIAADWMADLKEGICMTAFWFNHEQCCWDSKEATFEERDKCPQWQTWADLIIGQAEGPGSYIMNYIMYIFWALSFAFLAVCLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTVTLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELIPFILLGVFGGLWGAFFIRANIAWCRRRKTTRFGKYPVLEVMLVAAITAVIAFPNPYTRFNTSQLIKELFTDCGPLESSSLCDYKNDMNSSKIVDDIPDRPAGTGVYSAIWQLCLALVFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLARDVMRPRRSDPPLAVLTQDNMTVDDVESLINDTSYNGFPVIMSKESQRLVGFALRRDLTLAIENARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDQTPMEIVVDLFRKLGLRQCLVTHNGSNSVISIT
Protein: Coiled-coil domain-containing protein 39 (P0CK98)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9UFE4}.
Interaction partners:
- Coiled-coil domain-containing protein 40
- Dynein regulatory complex subunit 2
- Axonemal dynein light intermediate polypeptide 1
- Radial spoke head protein 9 homolog
- Dynein axonemal assembly factor 19
- Dynein regulatory complex protein 1
- Dynein, axonemal, heavy chain 5.
- Radial spoke head component 4A.
- Armadillo repeat containing 4
- Dynein axonemal assembly factor 11
Sequence:
MSSALLEEVGWDADFAIPVANAENKALEEQIRKKQKDILNLDNKLNKHKDVINALTEHLKNLKQEVSHNQALCKAKEKETESEVHLKALAERETGRLKQEITRLESQLTTLNEKKNAQENSIFKATQKIDELTSQLNWDQQTLEAFLQESAHKDEDTMAIIKYAKQDERKIKELTLNIEKLTLESNQKRKTLDNELTETVTSQIALDKTAESFRQAHTERQELISQWENTIEQMRKRDQDIQQCAMMLAELNQTIREKNDLIKERKDFLEREIENNKELERNIGTVERQAFRLRQQLQEEEKNQRRLQDEVEVLKGTVDRTATDVETSRSQLSSMKKDIQDKTTKVEEAQLHNAALEEKLRMVTEAVLNGEEQAAQMEQLLREQEQNIKEIDSQLLRQKELLFKKSQEVQALRDKEKNVTAEICATRTALSNLDSKLRKLDQNFLQQQMIISNQDFQIQMLERKTLHLQGKVNTEEKKALEKKVADLAASLEEKKKTAANLNKQLKKLQDDIRCIKKDTEKIGAEKTNLSTKIQEVELFIETSEKERKKSRLKKQDSMVEKGLLKMEVQRLRNLLYDRADGVLTLEKRRLQLQTAMKEREEEIRVHREMLNKQVKLTEQERQGLSAAVNEAMSKIDKQRKRYEVLSVSLAPPEGEEDKSQAYFIIKAAQEKEELQRKGDELDAKIRKTEKEIHALENTLQVVNNCNSTHRKALTKVTESSPAHQEKLKLEEQRRAAEEKYKYKRRQTQELQEDIESMSNTLEGLLQEEKVLNEGIERTQAHVLSLNKDILSQEEKINRAVKQCAKYTKEIRSGKQSTEKTFEERDIELRELRDFNKSINKMLLDAMEGNPELSSILQIHFTQAGLSLPSPSSTPSSRLSSKPSSARSSASLHRSSNLSASSSPRSQSVSSPQMKTVDLGLGLSVTSPRGSQPSSAGSSRSSSKCKSP
Protein: Growth/differentiation factor 6-A (GDF-6-A) (Growth differentiation factor 6A) (Protein radar) (P85857)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase receptor
- Chordin
- Serine/threonine-protein kinase receptor
- receptor protein serine/threonine kinase
- Receptor protein serine/threonine kinase
- Receptor protein serine/threonine kinase
- Receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Serine/threonine-protein kinase receptor
- Serine/threonine-protein kinase receptor
Sequence:
MDALRAVAFYALFVFLWSLPCCQSAALISQKRSKGARSAFDGQRSHKFLKEILASSPGASRRDDFKDPVVPHDYMISIYRTYSAAEKLGLNASFFRSSKSANTITSFVDKGKDDLTLSPLRRQTYLFDVSTLSDKEELVGAELRIFRKSPGDVQPSPSGVYNLHLLSCRSERPLASRSIDLQDSRKAEWEVLDVWGIFKHRHQENQLCLQLKVTYGKSDTEIDLKQLGFHRHSRTQQERAILVVYTRSKKRENLFNEMKEKIKSRGDDDEEESALQFKARRRRRTALNNRHGKRHGKKSKSRCSKKALHVNFKELGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPNSTPPSCCVPTKLSPISILYIDSGNNVVYKQYEDMVVEQCGCR
Protein: Homeo box B1b (A3KNJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MNSYLDYTIYNRGSNTYSSKVGCFPVEQEYLPSACASTNSYIPEGRPVGGNTFTSAPHETHGTSYAQIQSQPFHLNVDMGKTGHSNFCKQTRPPHSDYGHQHVLTQADDHMRLQSPGFSVVNMGANIGTYSESNCRPGSVSASHYQSYAYGEPEPHGYGSFSKYQVSPDSDSDSKTNIKQAPTFDWMKVKRNPPKTVKVAEYGIHGQQNIIRTNFTTKQLTELEKEFHFNKYLTRARRVEVAATLELNETQVKIWFQNRRMKQKKREKEGTAPVIKRVTLCSSGQNADHSTSSSPGASPTSDSSTAI
Protein: Short stature homeobox protein 2 (Homeobox protein Og12X) (Paired-related homeobox protein SHOT) (O60902)
Organism: Homo sapiens (Human)
Function: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
Subcellular location: Nucleus.
Interaction partners:
- T-box transcription factor TBX18
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
- T-box transcription factor TBX3
Sequence:
MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL