wanglab/gogpt-training-data huggingface dataset:
Protein: U3 small nucleolar RNA-associated protein 18 (U3 snoRNA-associated protein 18) (U three protein 18) (P40362)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15590835}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein LCP5
- U3 small nucleolar ribonucleoprotein protein IMP3
- Protein BFR2
- U3 small nucleolar RNA-associated protein 21
- Nucleolar complex protein 4
- Probable ATP-dependent RNA helicase DHR2
- U3 small nucleolar RNA-associated protein 22
- Ribosome biogenesis protein SLX9
- Pre-rRNA-processing protein PNO1
- U3 small nucleolar RNA-associated protein 4
Sequence:
MTMATTAMNVSVPPPDEEEQLLAKFVFGDTTDLQENLAKFNADFIFNEQEMDVEDQEDEGSESDNSEEDEAQNGELDHVNNDQLFFVDDGGNEDSQDKNEDTMDVDDEDDSSSDDYSEDSEEAAWIDSDDEKIKVPILVTNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSELDDEEDDEEEGSNNVINGDINALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY
Protein: Centrosomal protein 290 (A0A8I5ZYJ8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MPPNIKWKELIKVDPDELPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDTVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELRKDKGTSNIYQQTHYMKIHSKVQILEEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNYKAQIKIRDGEIEVLTKEINKLEMKINDVLDENEALRERAGLEPKTMIDLTEFRNSKRVKQQQYRAENQILLKEIESLEEERLDLKRKIRQMAQERGKRSAASGLTIDDLNLTETFSHGDKIGERKLNFISFNNMNETQSKNETIAQDLSIQEEQSRNAHLDLDHQRSQEEQNEFLSRELIEKEKDLERSRTVITKFQNKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGSETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAVNYSQQLVKANLKIDHLEKETDLLRQSSGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDVWKADSEMIKEEKRKLEDQAQQDAVKVKEYNNLLNALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEIERQLRKENGKHKNDVISMEAEVTEKIGNLQRFKEMATFRIAALQKVVDNSVSLSELELANKQYSELTAKYRDVLQKDNMLVQRASNLEHLACENASLKEQMEGLSKELEITKEKLHTIEQAWEQETKLGNESNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKHMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVNKAVSDADRQRILELEKREVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRMQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEACNLRLEQKLDEKEQALYYARLEGRNRANHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTISSLEEDIVQQSKFHEERQMAWDQREVELERQLDIFDRQQNEILSAAQKFEDATGSMPDPSLPLPNQLEIALRKIKENIQIILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLQLPATADREKLIAELNRTELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLSKFKQTAQDLIKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKRVSRDLERQKEVTEFKVREFETTKLRLQETHANEVKKVKAEVEDLRHALAQAQKDSQNLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTKELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNDLNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERQVDDVDIKPIKEKSGKEELIRWEEGKKWQTKVEGMRNKLKEKEGEVHSLTKQLSTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKRRNLDLENDIVYMRTHQALPRDSVVEDLHLQNRYLQEKLHTLENKLSKDAYSQSLTSEIESDDHCQKEQELQRENLKLSSENIELKFQLEQAKKDLPRLKNQVRDLKEMCEILKKGKMELERKLGQVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGLLTSEKMATLEEENGKLKAELEKLKAHFGRQLSMQFESKSKGTERIMAENERLRKELKKEMQASEKLRIAKNNLELVNDKMAGQLEETGKRLQFAESRGPQLEGADSQSWKSIVVSRIYDTKIKDLESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIQQLQLLRLANNQLDKEKAELIHQIEVIKDQTGAESSTPDSDQLKKKINDLETHLRKSEPEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLNKLSEQFGFELPSPLAASEQREDGESPNGVPIY
Protein: REST corepressor 1 (Rcor1 protein) (A1L228)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAMLEKGTTEISGKRRGRNSVNNPTKSFTSNGNSNNSWEEGSSGSSSDDEHGAGGMRVGPQYQAVVPDYDPEVAKASHERENLGMLVWIPKTSIPEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQGFSFHGKTFHRIQQMLPDKSIASLVRFYYSWKKTRSKTSVMDRHARKQKREREESDEEEENGSTSPGDTELEPNKEEKKEGTSGTEKQESKPAVVQKPAILAEKPMHVKKEAQGLAGRNLNRAKKKPPKGMYLSADDVTAMSSSGPAAVSVLRGLDMELIAIKRQIQSIKQHNSALREKLDTGVDEFRPSESNQKFNTRWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNLDEVLQEWEAEHGVEERKGLDEEKMEVSSEDGTTSGPAENQTEEQTPMETQNPSVS
Protein: Ferrisiderophore receptor-like protein (VreA) (O69004)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
Sequence:
MSILGVARSCAVSLLGLGMLLPASGAVPGDGGRPPLRLAVHAFDIPPQSLASALVTYSGVTGMAVLVDGELARGRRSARLQGRFTASDALTRLLGGTGLMARYTSQEAFTLLPAQAVRNAAPLPAEMPKVEQPLDRRYAGAVQAALEEQLCRSPRTRPGTYRAVLQLWIGRFGEVRHSRLLGSTGDPQRDSALVESLRGVRVMQATPATLAQPLTILLLPKTTGKAMECKLTEGVGGS
Protein: Mitochondrial pyruvate carrier (Q5A328)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}.
Interaction partners:
- Mitochondrial pyruvate carrier
Sequence:
MASTVQHASKFQRFLNSETGPRTVHFWAPVFKWALVAAGLNDIQRPVEKLSGTQQIALFATGAIWTRWAGFVIKPRNMLLASVNFFLGGVAGYQLLRIVNYRRDLGDSPMQVFNYILNGDAAAVKEPEPAKN
Protein: Collagen like tail subunit of asymmetric acetylcholinesterase (A0A0C4DGS2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRDCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT
Protein: Emerin (Q5HY57)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDNYADLSDTELTTLLRRYNIPHGPVVDLNSTRGDADMYDLPKKEDALLYQSKGYNDDYYEESYFTTRTYGEPESAGPSRAVRQSVTSFPDADAFHHQVHDDDLLSSSEEECKDRERPMYGRDSAYQSITHYRPVSASRSSLDLSYYPTSSSTSFMSSSSSSSSWLTRRAIRPENRAPGAGLGQDRQVPLWGQLLLFLVFVIVLFFIYHFMQAEEGNPF
Protein: Meiotically up-regulated gene 144 protein (Q09902)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MGKLVKHCHTSLHSELVILFYAKNRFCISIDHLRPLKSHRTHGHYCLLNFSLRENKNYLIIVYLPIEGFSANHMCISHGTSFNIK
Protein: Vesicle-associated membrane protein-associated protein scs2 (VAMP-associated protein scs2) (VAP homolog 1) (O60119)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Vesicle-associated membrane protein-associated protein (VAP) implicated in maintaining the cortical endoplasmic reticulum (ER)-plasma membrane (PM) attachment. ER-PM contacts function to modulate the distribution of contractile ring components to ensure robust ring assembly. ER-PM contacts function also in controlling exocytosis and maintenance of cell polarity regulating cell shape. VAPs play an important role in regulating eisosome assembly. VAPs also contribute to ER-phagy by tethering atg8 to the ER membrane, but also by maintaining the ER-plasma membrane contact (Ref.8).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23041194}; Single-pass type IV membrane protein {ECO:0000255}. Note=Localizes at the cortical endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:23041194}.
Interaction partners:
- Oxysterol-binding protein homolog C2F12.05c
- Oxysterol-binding protein homolog C23H4.01c
- Uncharacterized protein C691.05c
- Uncharacterized protein C962.01
- Reticulon-like protein 1
- Oxysterol-binding protein homolog C23B6.01c
- Uncharacterized protein PYUK71.03c
- Uncharacterized protein C23C11.01
- Probable sphingolipid long chain base-responsive protein pil1
- Uncharacterized membrane protein C660.17c
Sequence:
MSVECSGELFFYPPFTTMSKELISVHNPNPEPVIFKVKTTAPKHYCVRPNSGKIEPKSTVNVQVLLQAMKEEPAPDFKCRDKFLIQSMAIGDADTSNVENYHEFWTEMEKQGRSIFDRKIRCVYSTKQPPQSADKQVENTSTSNPPVSVEGSENLASSVGGPTAVGVSLDEAQNDFNGAKDHLSNGVNTVVPDSTFRSTFESAQIPDASVVQTVVTDADNGAASVKDTIVTAESASSKGADVARSKVQDIIDNEIPKPSESPRRSVSSTPPVHPPPPVPQNLSAVNEEFDTKKNDFDSKLPESTPAVEKVSENLGSETRESLQGAKPAAGAHSSDNALEQIKPSYSADPSSSTGASLTESPGIPPNIVIILCLIFFLIGYLFF
Protein: Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ (Flavocytochrome MsrQ) (P76343)
Organism: Escherichia coli (strain K12)
Function: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
Subcellular location: Cell inner membrane; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01207, ECO:0000305|PubMed:26641313}.
Interaction partners:
- Protein-methionine-sulfoxide reductase catalytic subunit MsrP
- 5-hydroxyisourate hydrolase
Sequence:
MRLTAKQVTWLKVCLHLAGLLPFLWLVWAINHGGLGADPVKDIQHFTGRTALKFLLATLLITPLARYAKQPLLIRTRRLLGLWCFAWATLHLTSYALLELGVNNLALLGKELITRPYLTLGIISWVILLALAFTSTQAMQRKLGKHWQQLHNFVYLVAILAPIHYLWSVKIISPQPLIYAGLAVLLLALRYKKLRSLFNRLRKQVHNKLSV
Protein: Chitin-binding protein (GlcNAc-binding protein A) (Lytic polysaccharide monooxygenase) (O83009)
Organism: Serratia marcescens
Interaction partners:
Sequence:
MNKTSRTLLSLGLLSAAMFGVSQQANAHGYVESPASRAYQCKLQLNTQCGSVQYEPQSVEGLKGFPQAGPADGHIASADKSTFFELDQQTPTRWNKLNLKTGPNSFTWKLTARHSTTSWRYFITKPNWDASQPLTRASFDLTPFCQFNDGGAIPAAQVTHQCNIPADRSGSHVILAVWDIADTANAFYQAIDVNLSK
Protein: WASH complex subunit 5 (WASH complex subunit strumpellin) (Q7ZVM1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting.
Subcellular location: Early endosome {ECO:0000305}.
Interaction partners:
- WASH complex subunit 3
- WASH complex subunit 1
- WASH complex subunit 4
- WASH complex subunit 2C.
- Vacuolar protein sorting-associated protein 35
- Receptor expression-enhancing protein.
- Spastin
- Proteasome inhibitor PI31 subunit
- Uncharacterized protein.
- SPG11 vesicle-trafficking-associated, spatacsin.
Sequence:
MVDFLAENNLCGQAILRIVSRGNAIIAELLRLSDFIPAVFRLRDKTDQQKYGDIICDFSYFKGPEYYEGKLEAKPELQDLDEEFRENNIEILTRFYLAFESVHKYVVDLIRCLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKMEGEVRERMLVSYYRYSAARSSADSNLDDICKLLRSTGYSSHPGAKRPTNYPESYFQRVPISSTFISMVIGRLRSDDIYNQVSAYPLPEHRSTALATQAAMLYVCLYFTPSILHTQQAKMREIVDKYFPDNWVISIYMGITVNLVEAWEPYKAAKIALNYTLDTANIREQAGRYAASVETLRPQVQQLLKEGFLREEIILDNIPKLLNCLRDCNVAIRWLMLHTAESAYDPNNKRLRQIKDQVINDSKYNPKILFQLLLDTAQFEFILKEMFKQMLAEKQLKWESYKKEGSERMMELAEVFSGVKPLTRVEKNENLQAWFREISKQIESLNYEDSTAAGRKTVQLIQALVEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSYAWQIIDSFTAIMQESIRANPSMVTKLRATLLKLASALDLPLLRINQVNSPDLLSVSQFYSGELVAYVRKVLQIIPESMFTSLAKIIKLQIHDIMEVPTRLDKDKLKDYSQLSARYEVAKLTHAISVFTEGILMMKTTLVGIIQVDPKQLLEDGIRKELVKRVAYALHKGLIFNPKAKPSELMPKLKEMAATMDGFYRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNSFLRTKIQDWQSVHQSTHIPIPKYPSVDESATFIGRLCREILRITDPKVTCYIDQLNTWYDLRTHQEVTNNRLFSEIQDTLGTFGLNGLDRLLCFMIVKELQNFLTVLQKSILKDKAVVDVFKALLTAVNPVKGIVANASKVYTNAAAKTQKIWSPYLESIMKVGQMQILRQQIANELNYSCKFDSKHLAAALDNLNKSLLSDIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKSQGMACRKPADALDWAPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSIMEQCTSQKIPDMPSDVVGALMFLEDYVRYTKLPRKVAEAHVPSFIFDEFRTVL
Protein: Sodium/hydrogen exchanger 9B2 (NHA-oc) (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Soditlum/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) (Q5BKR2)
Organism: Mus musculus (Mouse)
Function: Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:20441802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Mitochondrion membrane {ECO:0000269|PubMed:17988971}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Endosome membrane {ECO:0000269|PubMed:23720317}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Lysosome membrane {ECO:0000269|PubMed:20441802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Recycling endosome membrane {ECO:0000269|PubMed:32956652}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:23720317}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:27010853}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Basolateral cell membrane {ECO:0000269|PubMed:20441802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Apical cell membrane {ECO:0000269|PubMed:27909897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts (PubMed:20441802). In beta-cells colocalizes with RAB4A and SYP (PubMed:23720317). Localizes to the basolateral membrane of polarized osteoclasts (PubMed:20441802). Localizes to the apical membrane of distal convoluted and connecting tubules (PubMed:27909897). {ECO:0000269|PubMed:17988971, ECO:0000269|PubMed:20441802, ECO:0000269|PubMed:23720317}.
Interaction partners:
- Sodium/hydrogen exchanger 6
Sequence:
MEDEDKTAECQHSKPPTGITHEAPPHHELQEERVMSLRGTDRSEPTEGSNLLTSGEKKPQDSPTEPNGLQSLRRFLACPPRGCLARVITNGTMVVLLWAMVWSVTGPECLPGGNLFGIIILFYCSITGGKLFGLIKFPTLPPLPPLLGMLLAGFLLRNIPVINDSVRIQHKWSSSLRSIALSVILVRAGLGLDSKALRKLKGVCVRLAMGPCIVEACASAILSHFLMGLPWQWGFILGFVVGAVSPAVVVPSMLLLQEGGYGVGKGIPTLLMAAGSFDDILAITGFNTCLGVAFSTGSTVFNIFRGILEVVIGVAAGSFLGFFIQYFPSRDQDNLVWKRAFLVLGFAVLAVFSSVYFSFPGSGGLCTLVMAFLAGMRWTDKKSEVEKVIAVTWDVFQPLLFGLIGAEVSIVSLRAETVGLCVATLSIAVLIRILTTFLMVCFAGFNIKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLAILITAPIGSLLIGLLGPRVLQKSEHRTEEEVQGETSAHIQRKPEDSITEA
Protein: ATP-dependent rRNA helicase RRP3 (EC 3.6.4.13) (Ribosomal RNA-processing protein 3) (P38712)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Something about silencing protein 10
- U3 small nucleolar ribonucleoprotein protein LCP5
- Pre-rRNA-processing protein ESF1
- U3 small nucleolar RNA-associated protein 14
- U3 small nucleolar RNA-associated protein 7
- rRNA biogenesis protein RRP5
- ATP-dependent RNA helicase ROK1
- KRR1 small subunit processome component
- Nucleolar complex protein 14
- Ribosome biogenesis protein ERB1
Sequence:
MSKIVKRKEKKANDELTSLAEKIRAKALENQKKLIEAEKEGGSESDSEEDATAEKKKVLKSKSKSTVSTQNENTNEDESFESFSELNLVPELIQACKNLNYSKPTPIQSKAIPPALEGHDIIGLAQTGSGKTAAFAIPILNRLWHDQEPYYACILAPTRELAQQIKETFDSLGSLMGVRSTCIVGGMNMMDQARDLMRKPHIIIATPGRLMDHLENTKGFSLRKLKFLVMDEADRLLDMEFGPVLDRILKIIPTQERTTYLFSATMTSKIDKLQRASLTNPVKCAVSNKYQTVDTLVQTLMVVPGGLKNTYLIYLLNEFIGKTMIIFTRTKANAERLSGLCNLLEFSATALHGDLNQNQRMGSLDLFKAGKRSILVATDVAARGLDIPSVDIVVNYDIPVDSKSYIHRVGRTARAGRSGKSISLVSQYDLELILRIEEVLGKKLPKESVDKNIILTLRDSVDKANGEVVMEMNRRNKEKIARGKGRRGRMMTRENMDMGER
Protein: Acid phosphatase PHO12 (EC 3.1.3.2) (P38693)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Inorganic phosphate transporter PHO84
- Acid phosphatase PHO11
- Repressible alkaline phosphatase
- Repressible acid phosphatase
- Constitutive acid phosphatase
- Low molecular weight phosphotyrosine protein phosphatase
- Thiamine pyrophosphokinase
- Phosphate system positive regulatory protein PHO81
- Thiamine biosynthetic bifunctional enzyme
- Probable acid phosphatase DIA3
Sequence:
MLKSAVYSILAASLVNAGTIPLGKLSDIDKIGTQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDDYEFFIRDTKNLEMETTLANSVNVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSNRCHDTAQYFIDGLGDKFNISLQTISEAESAGANTLSAHHSCPAWDDDVNDDILKKYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGYSDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESEVQDQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHVPFMENTFHRSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYGYAEKRVAGTDFLKVCNVSSVSNSTELTFFWDWNTKHYNDTLLKQ
Protein: Protein IWS1 homolog 2 (AtIWS2) (O49413)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in RNA polymerase II (RNAPII) transcription regulation. Involved in transcription elongation. May function at post-recruitment and elongation steps of transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
Interaction partners:
- Transcription elongation factor SPT6 homolog
- Transcription elongation factor SPT6-like
- FACT complex subunit SSRP1
- GDSL esterase/lipase At4g18970
- Pentatricopeptide repeat-containing protein At4g18975
- FACT complex subunit
- FACT complex subunit SPT16
- Protein CTR9 homolog
- Protein LEO1 homolog
- Protein S40-3
Sequence:
MQELDSSNDEWVKELEGENEESKFTGRRLVKKSISVPELVDEVEEDLDDFTEPADDFNDKVGKKRQRKKKDESGLEKTKKNKKQNSEEVQEMWDSITNNTNSQYGDKVVVKPPKKKDEDAEEIKKLFSLRKKKSKCDKTSMEIGMQVEQVMANLEIAVEDDVICNREGKPAINKLMKLPLLNETLSKKPLQGEFLDHGVLNLLKNWLEPLPDGSLPNINIRSAVLMILNDFRIDLDQDSRREQLIKSGLGKVIMFLSKSDEETTPNRRLANDIINKWGRIIYNKSTRYDNMFTQEELDEQRQILLRRQTKTAPKVSGTRARDFNTDIDLYELGTWTGRARAKIPTTMSMDFKIRPPSKVDINQEEEPCSKWQMEKRHKNKQQKNIRKGGMQALKLSVDGRTMLKYL
Protein: Heparin-binding fibroblast growth factor receptor 2 (Q63236)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
CYHNISVQMGLTSTWRYGTGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEACVVAPGESLELRCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACAAARTVDSETLYFMVNVTDAISSGDDEDDTDSSEDFVSENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKL
Protein: Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA) (P35542)
Organism: Homo sapiens (Human)
Function: Major acute phase reactant.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
Interaction partners:
- Serum amyloid A-2 protein
- Apolipoprotein A-I
- Transthyretin
- Apolipoprotein A-II
- Apolipoprotein C-III
- Serum amyloid A-1 protein
- Apolipoprotein F
- Apolipoprotein A-IV
- Apolipoprotein C-II
- Apolipoprotein B-100
Sequence:
MRLFTGIVFCSLVMGVTSESWRSFFKEALQGVGDMGRAYWDIMISNHQNSNRYLYARGNYDAAQRGPGGVWAAKLISRSRVYLQGLIDCYLFGNSSTVLEDSKSNEKAEEWGRSGKDPDRFRPDGLPKKY
Protein: Histone H3.3 type a (Histone 3, variant 3 type a) (O15819)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome. Note=Associated with pericentromeric heterochromatin.
Interaction partners:
- Histone H4
- Histone-lysine N-methyltransferase set1
- Histone H2B.v3
- Histone H2A.z
- VWFA domain-containing protein
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- PHD zinc finger-containing protein
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase roco5
Sequence:
MARTKQTARKSTGAKVPRKHIGSKQAHKQTPVSSSSGGVKKVHRFRPGTVALREIRKYQKSTDLLIRKLPFQRLVREIAQEFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIHLARRIRGERS
Protein: Lipoprotein LpqB (P9WK37)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division (By similarity). Partially restores antibiotic resistance to M.smegmatis in which this gene has been disrupted.
Subcellular location: Cell membrane {ECO:0000305|PubMed:20233304}; Lipid-anchor {ECO:0000305|PubMed:20233304}. Secreted, cell wall {ECO:0000269|PubMed:20233304}.
Interaction partners:
- Sensor histidine kinase MtrB
- DNA-binding response regulator MtrA
- Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW
- Uncharacterized protein
- Probable conserved lipoprotein LppL
- Carboxylesterase/lipase Culp6
- Possible lipoprotein LprC
- Possible protease
- Possible conserved secreted protein
- Probable arabinosyltransferase A
Sequence:
MERLMRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSPGMDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAEKVSVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSDGWRIDRLPNGVFLDWQQFQETYKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLLAPPLRLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADIRGPYVINADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVTPVPGAFGRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHSLSRPSWSLDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSRDGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPGAAPVLPG
Protein: Solute carrier family 25 member 44 (Q96H78)
Organism: Homo sapiens (Human)
Function: Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (By similarity). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis.
Subcellular location: Mitochondrion membrane {ECO:0000250|UniProtKB:Q8BGF9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Inosine-5'-monophosphate dehydrogenase 2
- Polyamine-modulated factor 1
Sequence:
MEDKRNIQIIEWEHLDKKKFYVFGVAMTMMIRVSVYPFTLIRTRLQVQKGKSLYHGTFDAFIKILRADGITGLYRGFLVNTFTLISGQCYVTTYELTRKFVADYSQSNTVKSLVAGGSASLVAQSITVPIDVVSQHLMMQRKGEKMGRFQVRGNPEGQGVVAFGQTKDIIRQILQADGLRGFYRGYVASLLTYIPNSAVWWPFYHFYAEQLSYLCPKECPHIVFQAVSGPLAAATASILTNPMDVIRTRVQVEGKNSIILTFRQLMAEEGPWGLMKGLSARIISATPSTIVIVVGYESLKKLSLRPELVDSRHW