wanglab/gogpt-training-data huggingface dataset:
Protein: Symplekin (Q92797)
Organism: Homo sapiens (Human)
Function: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147). {ECO:0000269|PubMed:14707147}.
Interaction partners:
- Pre-mRNA 3'-end-processing factor FIP1
- Cleavage stimulation factor subunit 2
- Cleavage stimulation factor subunit 3
- Cleavage and polyadenylation specificity factor subunit 3
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 4
- pre-mRNA 3' end processing protein WDR33
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Poly
Sequence:
MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDLSSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNILSRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAKGNS
Protein: Aldehyde dehydrogenase family 2 member B4, mitochondrial (ALDH2a) (EC 1.2.1.3) (Q9SU63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses activity on acetaldehyde and glycolaldehyde in vitro.
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:25732537}.
Interaction partners:
- Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal
- Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial
- Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial
- Alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial
- Beta-ureidopropionase
- Acetate/butyrate--CoA ligase AAE7, peroxisomal
- Aldehyde dehydrogenase family 7 member B4
- Aldehyde dehydrogenase family 3 member I1, chloroplastic
- Aldehyde dehydrogenase family 3 member H1
- Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Sequence:
MAARRVSSLLSRSFSASSPLLFRSQGRNCYNGGILRRFGTSSAAAEEIINPSVQVSHTQLLINGNFVDSASGKTFPTLDPRTGEVIAHVAEGDAEDINRAVKAARTAFDEGPWPKMSAYERSRVLLRFADLVEKHSEELASLETWDNGKPYQQSLTAEIPMFARLFRYYAGWADKIHGLTIPADGNYQVHTLHEPIGVAGQIIPWNFPLLMFAWKVGPALACGNTIVLKTAEQTPLTAFYAGKLFLEAGLPPGVLNIVSGFGATAGAALASHMDVDKLAFTGSTDTGKVILGLAANSNLKPVTLELGGKSPFIVFEDADIDKAVELAHFALFFNQGQCCCAGSRTFVHEKVYDEFVEKSKARALKRVVGDPFRKGIEQGPQIDLKQFEKVMKYIKSGIESNATLECGGDQIGDKGYFIQPTVFSNVKDDMLIAQDEIFGPVQSILKFSDVDEVIKRANETKYGLAAGVFTKNLDTANRVSRALKAGTVWVNCFDVFDAAIPFGGYKMSGNGREKGIYSLNNYLQIKAVVTALNKPAWI
Protein: Protein transport protein Sec24C, putative (Q57XV4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein transport protein Sec31, putative
- Protein transport protein SEC23
- Protein transport protein Sec13, putative
- ADP-ribosylation factor, putative
- Protein transport protein SEC23
- Protein transport protein sec13, putative
- Sec16 Sec23-binding domain-containing protein
- Synaptobrevin-type vesicle transport protein, putative
- Longin domain-containing protein
- Syntaxin 5
Sequence:
MSYPHNFDHQAPPLQQLQQQVPPPLPHGSWAPQPNQGPGVPFNGVGPGITGAYGAASASGNAPTAQDWYYNQCPTSASGAPYSNGTNNFAYTPEMQYQPPHAQQQQQQQQLSYKIPSAAAAQPSFPGLGATAASSPHTPATVGQYSEHPPAARHHDVSERNEHRGIPCQENLRSFPAPQSRHSADSERQSTGPPPNYVRPPPRRAVDLVKAPNPNECVPPSSDSLMSNHSNLQFPSGADANISNASVKFFRPTMKWVPASANLVKDSRVPFGAVIAPLCQPVDPQEEVPCVSGYPPVRCQRCRAYVSCHARFTNMGRNWVCPLCSMCNDVSEEYFCNLDNQGQRLDKMQRPELSRGSVEFDVDAYPEYALRNSDDAALEARPLHYLFLLDVSVKAATTFLSDYVDALLRSLHEMAVQYPECRVAFITYASTLHFYNVRHPRMPQMIVSDVCNPFVPLPFTSLCWLTLGTELDLVDAFLLRVPEYASDLCETGCVLGAAVEVAKLVLSGQHGGRVIITAHKAPQNGIGAIKPREQHVLYGTEKEKELLRPLDGYWQTIATTCAKEQISLDLHMFADEYCELVTLSHPCHVTNGRVHLFSNYDSQTDAVELQAVLDQALLEEAGYAGILRVRCSTGLRVQRYHGHFFSQDKHDMDLVHVQGSSSFYVEFAHESKPDSSSAAYFQTALLYTTRRGNRRVRVHSVRIPIASSISSIFDGDTVAVLMAYIHQVISNSVNKGLKYAREQMHQQLLQLLTSYRRVVSQKSTSVLLMPGSLRLMPLYTLCVLKSDAIAEGTTVRIDDRVQKLFHLLTVPTHQCLSYFYPTLYAMHSSMEETFCGAINPETGDCVMPPRKRLFYESITTDGVYILCDEQARSVYLWVGSAVTPEISLELFGTANSAEVGRSVFFDHFGERLRNVLWACLNRDGRMRRLVILHQKDRGEEAFFKQLKEEGEGGTMSYDQLLLKLHKAVGELAL
Protein: Translin-associated protein X (Translin-associated factor X) (Q99598)
Organism: Homo sapiens (Human)
Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
Subcellular location: Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.
Interaction partners:
- Translin
- Protein argonaute-2
- Disrupted in schizophrenia 1 protein
- Translin-associated factor X-interacting protein 1
- Golgin subfamily A member 3
- Endoribonuclease Dicer
- Kinesin-like protein KIF2A
- Prostaglandin E2 receptor EP3 subtype
- Nuclear nucleic acid-binding protein C1D
- Protein argonaute-1
Sequence:
MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIFQVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTPSSDAQDKQFGTWRLRVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS
Protein: N-acetyltransferase domain-containing protein (Q385I1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTSLTSSSTNAVGRGRRVTRSLVGANTTGGGVLRCVCTAYLVSVQETLLECCRCRNWCHPACVGVDHAELRRYYTDNNYVCPFCRGMQKRERGESRAPAPRQTPLRLREVPDRAPFGFVTQLRNLLKVTTRAAQQAGYTIIDLPSTPLTEVMERQCLECCAEAIKEATFSEQYPLYCLKEVWTRAHPYMQGTLLRCSESGRIVSMVLSNGMDVYGNLRPTITQLKSGINRGIIDRKHQTAFMAACTKLDDVSDFVHITLSATHKDYQRRGLARMLMALDLLKWALRGRTRAYLNMALEKKVVDGGARLECVASPSSRRLYESFGFRDVYPRFDRETDEQRWTPKEADMGRVMAHLNFVEDLVIIASRYDPSGKKAAAPNQSSIANDGSASVATAADCAERVAANSNNGQAATQAQTPAGRRLSLFGKKS
Protein: Thin, isoform D (A0A0B4LFP7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQFEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGELPDPTSGQIMERCGVCSEKAYLSHCAHCEKKICEDCKSAHMDILRREITRFNSQIRRSLHRLQDSLAIIEKNTMSLQTNAISVTEEIDEIYQRITKAIKDRSDQLKGEIDRYLAVELRNLTTLKENLDLEITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLKTVEFLRHFEYENNDYSRRVRFLVSIDPNQLVMNLATFGDLNIAPHSTPSGGSVSSSHLAPPSALQPGLMRSKSDHRLATQFRQQEERSGYNDEPVLGGRKFGERPQRSATQANNDRYGRSGGDYDYENDYDNEGSSGRAGKSSRFRSRFVRSHQNDDSDSEQQQQQRQQELKERKDRVLDSEDVSRGQLSGIIRLSDCSRVVQRLADIGKEKKEKKSDAAAAAQAAVQAAIQAQKAAMQRQQQKNQQNAADEEELARQKRKNAGSSSTGGAATSTSSGGGDTASDQRVAALKNRGGEESDGSSNQAASPSKPPVSAQVAAVKKTQRSGSSDSSASTESSASSAAAAAVAATSTSATAAAPATSSSNSTSQNAKAPSSSRYSTARDTTAVPEKKPFVSRFLPQHSTASTTNGSADKKKAESSSSSEEETSSESESESEPETKAKSSATSSTTNTKSTPNSAASSTTAASSSTTSGSYRDRLEARRASRDDSSSTAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSRYSGYGSSDLSRSRSSHALKSRDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWARYLKNKYGNKSSKDSAGSSGSARDTHAGSSTSSSAAASSSHAHGYGSGTSGSSGRSTASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSPTSPTVAAAVAAAGITGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVLSTVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSEFKGLEGVAIMSNGNILVCDRENHRVQVF
Protein: Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5) (Q8WWZ7)
Organism: Homo sapiens (Human)
Function: Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8CF82}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CF82}. Lysosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Late endosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Cell membrane {ECO:0000250|UniProtKB:Q8K448}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000250|UniProtKB:Q8K448}.
Interaction partners:
- Elongator complex protein 6
Sequence:
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERTQEDRVVF
Protein: Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) (O94953)
Organism: Homo sapiens (Human)
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959}.
Interaction partners:
- Probable JmjC domain-containing histone demethylation protein 2C
- Estrogen receptor
- Lysine-specific demethylase 3A demethylase 3A)
- Lysine-specific demethylase 4A demethylase 4A) demethylase 4A)
- Histone H4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Lysine-specific demethylase 2B
- Histone H3.3
- Histone H3.1t
- Histone H3.1
Sequence:
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF
Protein: Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15) (C9JGN2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU364148}.
Interaction partners:
Sequence:
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQ
Protein: Peroxisomal membrane protein PEX14 (Peroxin-14) (P53112)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX21 receptors. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 (or PEX21) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:9094717}; Peripheral membrane protein {ECO:0000269|PubMed:9094717}; Cytoplasmic side {ECO:0000269|PubMed:9094717}.
Interaction partners:
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein PEX13
- Peroxisomal biogenesis factor 8
- Peroxisomal targeting signal receptor
- Peroxisomal targeting signal 2 receptor
- Peroxisomal biogenesis factor 2
- Peroxisomal membrane protein import receptor PEX19
- Peroxisomal membrane protein PEX17
- Peroxisomal membrane protein PMP27
Sequence:
MSDVVSKDRKALFDSAVSFLKDESIKDAPLLKKIEFLKSKGLTEKEIEIAMKEPKKDGIVGDEVSKKIGSTENRASQDMYLYEAMPPTLPHRDWKDYFVMATATAGLLYGAYEVTRRYVIPNILPEAKSKLEGDKKEIDDQFSKIDTVLNAIEAEQAEFRKKESETLKELSDTIAELKQALVQTTRSREKIEDEFRIVKLEVVNMQNTIDKFVSDNDGMQELNNIQKEMESLKSLMNNRMESGNAQDNRLFSISPNGIPGIDTIPSASEILAKMGMQEESDKEKENGSDANKDDNAVPAWKKAREQTIDSNASIPEWQKNTAANEISVPDWQNGQVEDSIP
Protein: Murein peptide amidase A (EC 3.4.17.-) (Gamma-D-Glu-Dap amidase) (Zinc metallocarboxypeptidase MpaA) (P0ACV6)
Organism: Escherichia coli (strain K12)
Function: Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. Has weak activity with L-Ala-gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap. Cannot hydrolyze murein tetrapeptide.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02211, ECO:0000305|PubMed:12511517}.
Interaction partners:
- L-Ala-D/L-Glu epimerase
- Murein tetrapeptide carboxypeptidase
- Periplasmic murein peptide-binding protein MppA
- Cytosol non-specific dipeptidase
- Uncharacterized protein YcjY
Sequence:
MTVTRPRAERGAFPPGTEHYGRSLLGAPLIWFPAPAASRESGLILAGTHGDENSSVVTLSCALRTLTPSLRRHHVVLCVNPDGCQLGLRANANGVDLNRNFPAANWKEGETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDPRHSELGEWLAQAFELPLVTSVGYETPGSFGSWCADLNLHCITAEFPPISSDEASEKYLFAMANLLRWHPKDAIRPS
Protein: Bub3, isoform A (Bub3, isoform B) (FI07632p) (Q9VAJ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cell division cycle protein 20 homolog
- Bub1-related kinase
- Mitotic spindle assembly checkpoint protein MAD2A
- Bub1 kinase, isoform A
- Cell division cycle protein 27 homolog
- Bub3 interacting GLEBS and zinc finger domain protein, isoform F
- Cyclin-dependent kinase 1
- Anaphase-promoting complex subunit 4
- Aurora kinase B
- Cyclosome subunit 8
Sequence:
MRPPEFKLNNPPEDLISAVKFGPKSNQYMAASSWDGTLRFYDVPANQLRQKFVQDAPLLDCAFMDIVHVVSGSLDNQLRLFDVNTQAESIIGAHEEPIRCVEHAEYVNGILTGSWDNTVKLWDMREKRCVGTFEQNNGKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNKEGYVMSSIEGRVAVEYLDHDPEVQRRKFAFKCHRNREQNIEQIYPVNALSFHNVYQTFATGGSDGIVNIWDGFNKKRLCQFHEYDTSISTLNFSSDGSALAIGCSYLDQLPETPATVPHPAIYIRYPTDQETKQK
Protein: RE54550p (Rab40, isoform B) (Q8IR80)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Exonuclease mut-7 homolog
- LD30155p
- tRNA
- Protein NipSnap
- Histone chaperone asf1
- U3 small nucleolar RNA-associated protein 15 homolog
- Actin-histidine N-methyltransferase
- FI13065p
- Structural maintenance of chromosomes protein
- Calpain-D
Sequence:
MGTMTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGKRVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPGIPKVLVGNRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWRSNKVLSLQELCCRTIVRRTSVYAIDSLPLPPSVKSTLKSYALTTSQCFNSLTQSSKSKNRCKTPTSSSRNSCAIA
Protein: Glideosome-associated protein 50 (PfGAP50) (Secreted acid phosphatase) (PfSAP) (EC 3.1.3.2) (Q8I2X3)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Component of the glideosome complex, an inner membrane complex structure involved in parasite gliding motility and host cell invasion. During the asexual blood stage, may play a role in the assembly and anchoring of the glideosome complex to the inner membrane complex. During the sexual stage in the vector mosquito midgut, protects gametocytes against host alternative complement pathway-mediated elimination by interacting with host complement inhibitor factor H. Has phosphatase activity towards nucleotides such as ATP, vitamins B1 and B6, phosphorylated sugars, glycerol phosphates and inositol triphosphates. However, the phosphatase activity is controversial.
Subcellular location: Inner membrane complex {ECO:0000269|PubMed:16321976, ECO:0000269|PubMed:16513191, ECO:0000269|PubMed:20070315, ECO:0000269|PubMed:21239623, ECO:0000269|PubMed:23332154}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:23332154}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21239623}; Single-pass type I membrane protein {ECO:0000305}. Note=During late-ring to mid-trophozoite stages, localizes to the endoplasmic reticulum (PubMed:21239623). During schizont maturation, re-localizes to ring-shape structures at the periphery (PubMed:21239623). Localizes to the apical end of the developing merozoites and then expands further around the surface of the nascent daughter cells (PubMed:21239623). During invasion, localizes to the interface between the invading merozoite and the host erythrocyte membrane (PubMed:16321976). Localizes to the inner membrane complex (IMC) in intraerythrocytic gametocytes (PubMed:23332154). Following gametocyte activation and disintegration of the IMC relocalizes to the macrogamete cell membrane (PubMed:23332154). {ECO:0000269|PubMed:16321976, ECO:0000269|PubMed:21239623, ECO:0000269|PubMed:23332154}.
Interaction partners:
- FAD synthase
- Oocyst capsule protein
Sequence:
MNYCKTTFHIFFFVLFFITIYEIKCQLRFASLGDWGKDTKGQILNAKYFKQFIKNERVTFIVSPGSNFIDGVKGLNDPAWKNLYEDVYSEEKGDMYMPFFTVLGTRDWTGNYNAQLLKGQGIYIEKNGETSIEKDADATNYPKWIMPNYWYHYFTHFTVSSGPSIVKTGHKDLAAAFIFIDTWVLSSNFPYKKIHEKAWNDLKSQLSVAKKIADFIIVVGDQPIYSSGYSRGSSYLAYYLLPLLKDAEVDLYISGHDNNMEVIEDNDMAHITCGSGSMSQGKSGMKNSKSLFFSSDIGFCVHELSNNGIVTKFVSSKKGEVIYTHKLNIKKKKTLDKVNALQHFAALPNVELTDVPSSGPMGNKDTFVRVVGTIGILIGSVIVFIGASSFLSKNMK
Protein: Lung adenoma susceptibility protein 2 (Q8CB14)
Organism: Mus musculus (Mouse)
Function: Might play a role in cell proliferation.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MAKLNTKLRGCSQESSVSSLLASGSLSGSRSDSAHSAHSSFVYKDQLYSSASEALQAYIDDFDLSREHPGANAVKVNTDGEIGNGLQFSSYVHIPDNAFVNLDPKQHFNPLYYRRETVNDMDAISLTTDDLLRLPADGCFSFPCVPPDHRPNKKYSGRQDSSDIKNSPSFYVDATSKSKNNIVPPYVYTNINGKKCGRPRTPKPINRENKCVSESSLSFPKESSFTEDSAERRLENYPRWLTSQKSDLSVSGVTSIPDVKYPIWLHNQDLLPEANTPRGYKLLNEDEYRPIHSYQTQRANQLLNKIDCFEYTFKPSNLTDSFSEYEGLGNEFKCQCDNPLLPGQSQKPFCGDKIELLILKAKKNLKQSAKDLPKPVEKDDSPCSLDKLEAERTWENVPVAFKSPVPVKADDSPQQSSRTQCVNAFLEDFLNGENQSSTLSGGKHHGPVEALKQMLFNLQTVQESFNKNKTTEPEEEIKQVSEDDLAKLQMKENMMPITRSLHKALQHLSRLRDLVDDTSGRQSPKK
Protein: Smog, isoform B (Q9VR40)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MELCIATKSKIETAQSSMPQSSQCSSSSNCRNYQKKCHQNQTNTQVQSTQRSNCSSHSDRDHLTNQQKQQNQRTNSATAASAAAATLSESTRCNIIISSSSSSSSSTKSSKNIREPSSSSSTQLNTLYSLLVLLIVGLATATASPSPSPSHAPFGRESRRDALLAYYKRAHLPQSSSSGISLGHKYHLLHDANGLDFDELTPTASSVSALSRAERFRLRKRSATPTTPATAAGVTSLDVATAAAAATDAAAKDAGSGKKPEEKCEPKVLETLPDEPFYDYTDIAEDAARQFIEFLSGKFPNANTPIAIDEPTRAEVSRRANGIASYALNEDDNLLAFAIAAPSIHTVVVKFRDNVTIPPDQVHNKAYLGSYWRELGAAWNSTDGTQEWGAPFRDCNLLTRRWLWPFRISFSEHRIKVVAAAFIAADEDVCNDGLEEVFGRRHGCDRNTTFCLLTENKPAATRDVYTCLCRESYYLPNSTLQGFRGDRVELSEGYDNYSCIPCPGGCTNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCCIVLGVIVFRQRKCKAIASGMWTVLETILLGIVLLYASVAVHFFPASTERCLLEPWLRELGFITCYGAIILKLYRHLVDFRTRKAHRWVLRDVDLLKYLGTMVFAVICYMAAFTASSLDLLESAQLESLREADTNTCHPLKWELVTQTSEMLILCFGLHLSIASRNANTQFRERQFLVTALTLEFLVSSSFYFLRFVYLPEMSPSAILLALFIRSQLTNSFALGLIFVPKLWYQHKQHPQRYNHDQ
Protein: RHO1 GDP-GTP exchange protein 1 (Protein kinase C suppressor SKC1) (P53046)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.
Interaction partners:
- GTP-binding protein RHO1
- Protein SLG1
- Protein MTL1
- Cell wall integrity sensor MID2
- Cell wall integrity and stress response component 3
- Cell wall integrity and stress response component 2
- RHO1 GDP-GTP exchange protein 2
- Rho1 guanine nucleotide exchange factor TUS1
- Protein kinase C-like 1
- GTPase-activating protein BEM2/IPL2
Sequence:
MNSNELDLRNKYFYEIFGKKRKSDTSTPTQLFSGSKVQTNINEISITNDEDEDSTEDENKASLKDYTLGHDTGARYRIAPDCSSHQLKASPVLHISTNLNSSPQSFTGDQISPTNKKISINDSTRQDKGNSCTTTSSPSQKRSNVLLPHVRKHSSPSLLSFSKNSGSHMGDPNQLSTPPTPKSAGHTMELHSSFNGKHSSSSTSSLFALESLKTQNRRSSNSSNHSSQYRRHTNQHQRHHSRSKSSPVSLTEISMIKGTPLVYPALLSLIAIKFKQTIKLSTHKKMGLLYRDSFTGKQAIDTLCLIIGSLDRNLGMLIGKSLEAQKLFHDVLYDHGVRDSVLEIYELSSESIFMAHQSQSSTSIANTFSSSSSSVNSLRTKTEIYGVFVPLTHCYSSTCSLEKLCYSISCPNRLQQQANLHLKLGGGLKRNISLALDKEDDERISWTNSVPKSVWESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAHINEIYSVNREFLKALAQRQSLSPICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNPNFARFDDEVSNSSLRHGIDSFLSQGVSRPGRYSLLVREIIHFSDPVTDKDDLQMLMKVQDLLKDLMKRIDRASGAAQDRYDVKVLKQKILFKNEYVNLGLNNEKRKIKHEGLLSRKDVNKTDASFSGDIQFYLLDNMLLFLKSKAVNKWHQHTVFQRPIPLPLLFICPAEDMPPIKRYVTENPNCSAGVLLPQYQTSNPKNAIVFAYYGTKQQYQVTLYAPQPAGLQTLIEKVKQEQKRLLDETKHITFKQMVGQFFHSYINTNRVNDVLICHAGKILLVATNMGLFVLNYATSINQKPVHLLHKISISQISVLEEYKVMILLIDKKLYGCPLDVIDDAENADFLFRKNSKVLFKYVAMFKDGFCNGKRIIMIAHHFLHAVQLLIVNPLIFDFNSGNFKKNLKAGLVDFSVDSEPLSFSFLENKICIGCKKNIKILNVPEVCDKNGFKMRELLNLHDNKVLANMYKETFKVVSMFPIKNSTFACFPELCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINSNFIEIRHIENGELVRCVLGNKIRMLKSYAKKILYCYEDPQGFEIIELLNF