wanglab/gogpt-training-data huggingface dataset:
Protein: SIT4-associating protein SAP155 (P43612)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulator of protein phosphatase SIT4. Involved in directing expression of TOR-repressed genes and in dephosphorylation of NPR1 in response to nutrient starvation. Negatively modulates K(+) efflux of the cell by the Na(+)-K(+)/H(+) antiporter NHA1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-1
- SIT4-associating protein SAP190
- SIT4-associating protein SAP185
- SIT4-associating protein SAP4
- Type 2A phosphatase activator TIP41
- Protein SDS23
- Serine/threonine-protein phosphatase PP2A-like PPG1
- Protein SDS24
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Autophagy-related protein 18
Sequence:
MSFWPFGQNLNHSNINKILDEYFHVLHELERINPSVGKAIPAIFNNVQERGTSDSLDSIPEEYSHGDEVKTARGDQKSRFEKDDQQERYEKEEEERSMNSSESSTTSFSSGSTSKTDLDEEDISNATAPMMVTTKNLDNSFIERMLVETELLNELSRQNKTLLDFICFGFFFDKKTNKKVNNMEYLVDQLMECISKIKTATTVDLNNLIDYQEQQQLDDSSQEDVYVESDTEQEEEKEDDNNSNNKKRRKRGSSSFGNDDINNNDDDDDANEDDESAYLTKATIISEIFSLDIWLISESLVKNQSYLNKIWSIINQPNFNSENSPLVPIFLKINQNLLLTRQDQYLNFIRTERSFVDDMLKHVDISLLMDFFLKIISTDKIESPTGIIELVYDQNLISKCLSFLNNKESPADIQACVGDFLKALIAISANAPLDDISIGPNSLTRQLASPESIAKLVDIMINQRGAALNTTVSIVIELIRKNNSDYDQVNLLTTTIKTHPPSNRDPIYLGYLLRKFSNHLSDFFQIILDIENDANIPLHENQLHEKFKPLGFERFKVVELIAELLHCSNMGLMNSKRAERIARRRDKVRSQLSHHLQDALNDLSIEEKEQLKTKHSPTRDTDHDLKNNNGKIDNDNNDNDDESDYGDEIDESFEIPYINMKQNIKLRTDPTVGDLFKIKLYDTRIVSKIMELFLTHPWNNFWHNVIFDIIQQIFNGRMDFSYNSFLVLSLFNLKSSYQFMTDIVISDEKGTDVSRFSPVIRDPNFDFKITTDFILRGYQDSYKFYELRKMNLGYMGHIVLIAEEVVKFSKLYKVELISPDIQVILQTEEWQYYSEEVLNETRMMYSKILGGGSYIDDGNGNIIPQLPDNTTVLTPNGDASNNNEILDSDTGSSNGTSGGGQLINVESLEEQLSLSTESDLHNKLREMLINRAQEDVDNKNTENGVFILGPPEDKNSNSNINNTNHNSNNSNNNDNNDNNDNDNDNTRNYNEDADNDNDYDHE
Protein: C-terminal binding protein 1 (Q7ZU55)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALMDKHKVKRQRLDRICEGIRPPILNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVAALLYHTITLSRDDLDKFKGLRVIVRIGSGFDNVDIKAAAELGIAVCNVPAASVEETADTAMCLILNLYRRVTWMHQALREGTRASSVEQIREVAGGAARIRGETLGIIGLGRVGQAVALRAKAFGFGVIFYDPYLPNGVERSLGLQRMATLQDLLMHSDCVSLHCSLNEHNHHLINDFTIRQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHETEPFSFSQGPLKDAPNLICTPHTSWYSEQASIEAREEAAREVRRAITGRIPDSLKNCVNKEYLMAASQWPSMEATTVHSELNGAAAYRFPAGLIGVAAGGLPGAGAGVEGIVAGSLPLAHAIAPVSHPPHTPSPGQPSKAEADRDIPSDQ
Protein: Small ribosomal subunit protein bS16m/bS16c (30S ribosomal protein S16-2, mitochondrial/chloroplastic) (Q9LTS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:18453549, ECO:0000303|PubMed:36423343}. Plastid, chloroplast {ECO:0000269|PubMed:18453549}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS9m
- 50S ribosomal protein L20
- At1g64880
- 50S ribosomal protein L33
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS2m
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS18c
Sequence:
MVVRIRLSRFGCKNRPFFRVMAADSRSPRDGKHLEVLGYFNPLPGQDGGKRMGLKFDRIKYWLSVGAQPSDPVQRLLFRSGLLPPPPMVAMGRKGGARDTRPVDPMTGRYVDAENKTVNANDNQPKEEDTEAKSA
Protein: Deaminase, putative (EC 3.5.4.-) (Q57W17)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- tRNA
- Bifunctional dihydrofolate reductase-thymidylate synthase
Sequence:
MVQDTGKDTNLKGTAEANESVVYCDVFMQAALKEATCALEEGEVPVGCVLVKADSSTAAQAQAGDDLALQKLIVARGRNATNRKGHALAHAEFVAVEELLRQATAGTSENIGGGGNCGAVSQDLADYVLYVVVEPCIMCAAMLLYNRVRKVYFGCTNPRFGGNGTVLSVHNSYKGCSGEDAALIGYESCGGYRAEEAVVLLQQFYRRENTNAPLGKRKRKDLSVV
Protein: Probable xyloglucan galactosyltransferase GT14 (EC 2.4.1.-) (Glycosyltransferase 14) (AtGT14) (Q84R16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions in xyloglucan synthesis by adding side chains to the xylosylated glucan backbone. Involved in the galactosylation of hemicellulose xyloglucan.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q7XJ98}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7XJ98}.
Interaction partners:
- Beta-glucuronosyltransferase GlcAT14A
- Beta-glucuronosyltransferase GlcAT14C
- Beta-glucuronosyltransferase GlcAT14B
- Beta-1,6-galactosyltransferase GALT29A
- Beta-1,6-galactosyltransferase GALT31A
- Beta-arabinofuranosyltransferase RAY1
- Fucosyltransferase 6
- Probable fucosyltransferase 4
- Hydroxyproline O-galactosyltransferase GALT2
- At1g53100
Sequence:
MRPKNYSQMEKPISITTGKFRTNNNNNHNNVWFVVPLFFILCFVLLCFDYSALFTDTDETAFSIPDVTQKSTSSEFTKDDNFSRFPDDPSPDSSCSGRYIYVHELPYRFNGDLLDNCFKITRGTEKDICPYIENYGFGPVIKNYENVLLKQSWFTTNQFMLEVIFHNKMINYRCLTNDSSLASAVFVPFYAGLDMSRYLWGFNITVRDSSSHELMDWLVVQKEWGRMSGRDHFLVSGRIAWDFRRQTDNESDWGSKLRFLPESRNMSMLSIESSSWKNDYAIPYPTCFHPRSVDEIVEWQELMRSRKREYLFTFAGAPRPEYKDSVRGKIIDECLESKKQCYLLDCNYGNVNCDNPVNVMKVFRNSVFCLQPPGDSYTRRSMFDSILAGCIPVFFHPGTAYAQYKWHLPKNHSSYSVYLPVKDVKEWNIKIKERLIEIPEERVVRLREEVIRLIPKVVYADPKYGSDGSEDAFELAVKGMLERIEEVREMMRQGKDGSDGFDDRDDYKYTFSPYEEPQVLA
Protein: Probable sterol O-acyltransferase 1 (EC 2.3.1.-) (Sterol-ester synthase 1) (Q10269)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable sterol O-acyltransferase 2
- Diacylglycerol O-acyltransferase 1
- Phospholipid:diacylglycerol acyltransferase
- Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1
Sequence:
MTDTPRILITPSPLSDISTTINKPNVHPSMSLLKALPECRLVVKSKGDKNNANVVEFPLDRHKQLLIAGKVYHDYKFKPRKSIFDRVTDPNYFAKSEFRGFYVLFWLSMAAWVLQLYARSYWQRDTLLGLPLARQVFRQFFVLFSSDFLMICLSFFSYGLQVCIEKNMIRWANLGYTIQTLWQGFYMVLAVYWVKHRDFPIVQCVFFTLHCAVLIMKQFSYSHHMGYISEIRILHNEYEKLLKFVRECLNSTEKDEKYTFELTFPNKPAETISTLQAEEIVALTAKYLSRQMRSEVGNVVYPDNINFFNYVDYLLVPSLVYSMEFPRVAHFRWHYMAFKAGSTFGLLALTLALVDWYFVPSAVAVKDLDFIGKLRIAPLLMNKIMFPAIILYLIMFYLIFDCILNAFAEITKFADRGFYGAWWNTVTWDEFSREWNKPVHVFLMRHVYHSSISGFKLKKSHAVLLTFLISALVHEFVMLLATGKFRCYILTFQLLQIPLYDLQQMFAFKKRDILGNVFFWIGMFTGPSFLCILYIVF
Protein: Uncharacterized protein (O07172)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- DNA-binding protein
Sequence:
MAGSVSAAAGIGWVGLNVTETNRDQCYRVERTTVDALTHPEYRVHTRGVQRVRVTRNARKHRVSKHRIVAAMRHCGVPVIQEDGSLYYQGRDTSGRLTEVVAVEADDGDLIITHAMPKEWKR
Protein: Serine-rich 25 kDa antigen protein (P21138)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: Plays a role in the adhesion to host cells. Involved in the adhesion to host apoptotic cells thereby facilitating their phagocytosis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1695007, ECO:0000269|PubMed:18086807, ECO:0000269|PubMed:7876162}; Peripheral membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:1695007, ECO:0000269|PubMed:18086807, ECO:0000269|PubMed:7876162}. Note=Appears to localize to some vesicle-like structures. {ECO:0000269|PubMed:18086807, ECO:0000269|PubMed:7876162}.
Interaction partners:
Sequence:
MFAFLLFIAFTSATNIILDLDQEVKDTNIYGVFLKNEASPEKLEEAEEKEKSSSAKPESSSNEDNEDDEDEKASSSDNSESSSSDKPDNKPEASSSDKPEASSSDKPDNKPEASSSDKPDNKPEASSSDKPDNKPEASSSDKPDNKPEASSSDKPDNKPEASSTNKPEASSTNKPEASSTNKPEASSTNKPEASSTSNSNDKSGSSSDNDNNNLDAASSPFIVFCAIIIAIIF
Protein: Extracellular signal-regulated kinase 7 (EC 2.7.11.24) (Q9W354)
Organism: Drosophila melanogaster (Fruit fly)
Function: Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase dSOR1
- Activating transcription factor-2
- mitogen-activated protein kinase kinase
- MAP kinase-activated protein kinase 2
- Myocyte-specific enhancer factor 2
- protein-tyrosine-phosphatase
- Myocardin-related transcription factor, isoform H
Sequence:
MANYQTAHAQERRIQELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKPVRVTKQARTTSAKQPTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAPPAPAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGKFHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTEAKAPIPKNRYSNKMCQEKKYKKKHHSMSCITRDTFPSETEHRQQREERAYQRQMKRELQLKESYRRRIEAESEPLKETTEQESKTIKVIEQKVCEHTEKKADESLSKDQQKDSITFGTCVRERIHHLELEMEKCTEELVDFVELNADVLNYANVSTHLKKLQRSKESDEKDEDDRRALPEGIGGPGSQNYEIFRQEQEKERQRQVQEFLARDETNEYDNLDLDHAYRAKYYTAYKEIGKELNPAPDSGGRDSGSEHSPGRDNYTTYADYFLKYTTPQQNWNDLERANGLQREHDRIYGLFWLNDRRQEEKYRRKLAQNDQEELPVHHHKACRHRHHKPNHHAPYDHMRPTEDDIQEADSLPESN
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (Q8IMC2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTKSALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQLDTII
Protein: Protein SUP-1 (Q9XWU2)
Organism: Caenorhabditis elegans
Function: May be involved in trafficking or stabilization of the vesicular acetylcholine transporter unc-17.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23051648}; Single-pass type I membrane protein {ECO:0000269|PubMed:23051648}. Perikaryon {ECO:0000269|PubMed:23051648}. Cell projection {ECO:0000269|PubMed:23051648}. Synapse {ECO:0000269|PubMed:23051648}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:23051648}.
Interaction partners:
Sequence:
MMSYIALAACIGLAMAANVDHDVKSAVNEVTTTKDGDTYCPVPLVGTKCGTSSIFHYWKCCGELNKECCFNLQTWVWVTLALFGVIFIASFVISLVRCICCRK
Protein: Protein BZZ1 (LAS17-binding protein 7) (P38822)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:12391157}. Note=localizes in cortical actin patches in a LAS17-dependent manner.
Interaction partners:
- Proline-rich protein LAS17
- Myosin tail region-interacting protein MTI1
- tRNA-splicing endonuclease subunit SEN2
- Verprolin
- Reduced viability upon starvation protein 167
- Myosin-5
- Myosin-3
- Protein YSC84
- Actin cytoskeleton-regulatory complex protein SLA1
- LAS seventeen-binding protein 1
Sequence:
MSADLSIGNEIKDSFKETHKWVQNNLKWLKDIEQFYRERAKLEKDYSERLSRLSAEYFNKKSSTSVPISVGDTPTTTPGSIEAAGVVAWNEILSQTDMISKDHDQLSTDFENHVANQLSGLFTKLDMTLSKINGFNNDMVNKKDNIYHELEKAKKDYDEACSTMEMARNRYTKASNDRNKKKLDEKEMEMNKCKNEYLIKINQANRTKDKYYFQDVPEVLDLLQDVNEAKTLFLNDLWLKAASVENDLGANVSKRLQAANSVVKQNKPSLNTAIFIKHNLKNWKEPQDFVYKPSPVWHDDEKFAVPSSLEVEDLRIKLAKAENDYNSLQDKTQNELSKLSTLNKIKHEMKTNEDNINATKFYDTLKEYLNVVSPFTSHETLKLQAEVQIESIQNNVPEEYDLSTDNIDLSKTKKKSGIFSKFKHNILNVDSKPSSGGSTGNGNGGPLHITSLFNTSRRTRLGSAPNNAGEDSDNNSIRTTSTNNTKKTTQNSSDDGKNKVLYAYVQKDDDEITITPGDKISLVARDTGSGWTKINNDTTGETGLVPTTYIRISSAATVKANDRGPAPEVPPPRRSTLPVRTMEAIYAYEAQGDDEISIDPGDIITVIRGDDGSGWTYGECDGLKGLFPTSYCK
Protein: NADH-dependent phenylglyoxylate dehydrogenase subunit alpha (EC 1.2.1.58) (Phenylglyoxylate:NAD oxidoreductase) (Phenylglyoxylate:acceptor oxidoreductase) (Q8L3B1)
Organism: Aromatoleum evansii (Azoarcus evansii)
Function: Involved in the anaerobic metabolism of phenylalanine and phenylacetate. Catalyzes the oxidative decarboxylation of phenylglyoxylate to benzoyl-CoA and CO(2). It can also react slowly with 2-oxo-3-methylbutanoate and use different electron acceptors such as benzyl viologen, methyl viologen, FAD or FMN, but NAD seems to be the physiological electron acceptor. Also catalyzes an isotope exchange between CO(2) and the carboxyl group which proves partial or complete reversibility of the oxidative decarboxylation reaction.
Interaction partners:
Sequence:
MSTATLEKAVAAKAPRKQKVILAEGNEAAALGVALARPDMVSVYPITPQSSLVEHVAKLIADGRMDADIVDAEGEHSVLSVLQGGALAGARTYTATCGPGLAFMFEPYFRTSGMRLPIVLTIVTRDGITPQSVWGGHQDAMTVREAGWIQVYCESVQEVLDTTVMAFKIAEHHDVMLPVNVCLDGNYLSYGASRVELPDQAVVDEFMGEKNVNWHVALDPLRPMAVDPLTGGTTGKGPQTFVRYRKGQCRGMQNALSVIEEVHADWAKRIGRSFAPLVEEYRLDDAEFAIMTLGSMTGAAKDAVDEAREAGKKIGLIKIKTFSPFPVEALKKALGKVKALGVIDRSVGFRWNCGPMYQETLGVLYRLGRHIPSISYIGGLAGADITIPHVHRVIDETEALLNGAVAPTEPVWLNEKD
Protein: Signal recognition particle subunit SRP54, chloroplastic (54 chloroplast protein) (54CP) (SRP54) (cpSRP54) (EC 3.6.5.4) (FFC) (Signal recognition particle 54 kDa protein, chloroplastic) (P37107)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cotranslational and post-translational sorting of thylakoid proteins. Binds GTP specifically. Activates the GTPase activity of CPFTSY when bound together. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids.
Subcellular location: Plastid, chloroplast stroma.
Interaction partners:
- Signal recognition particle 43 kDa protein, chloroplastic
- Signal recognition particle 9 kDa protein
- Signal recognition particle 14 kDa protein
- Signal recognition particle subunit SRP68
- Signal recognition particle 19 kDa protein
- Cell division protein FtsY homolog, chloroplastic
- Preprotein translocase subunit SCY1, chloroplastic
- Inner membrane protein ALBINO3
- Signal recognition particle subunit SRP72
- Signal recognition particle subunit SRP72
Sequence:
MEALQFSSVNRVPCTLSCTGNRRIKAAFSSAFTGGTINSASLSSSRNLSTREIWSWVKSKTVVGHGRYRRSQVRAEMFGQLTGGLEAAWSKLKGEEVLTKDNIAEPMRDIRRALLEADVSLPVVRRFVQSVSDQAVGMGVIRGVKPDQQLVKIVHDELVKLMGGEVSELQFAKSGPTVILLAGLQGVGKTTVCAKLACYLKKQGKSCMLIAGDVYRPAAIDQLVILGEQVGVPVYTAGTDVKPADIAKQGLKEAKKNNVDVVIMDTAGRLQIDKGMMDELKDVKKFLNPTEVLLVVDAMTGQEAAALVTTFNVEIGITGAILTKLDGDSRGGAALSVKEVSGKPIKLVGRGERMEDLEPFYPDRMAGRILGMGDVLSFVEKATEVMRQEDAEDLQKKIMSAKFDFNDFLKQTRAVAKMGSMTRVLGMIPGMGKVSPAQIREAEKNLLVMEAMIEVMTPEERERPELLAESPERRKRIAKDSGKTEQQVSALVAQIFQMRVKMKNLMGVMEGGSIPALSGLEDALKAEQKAPPGTARRKRKADSRKKFVESASSKPGPRGFGSGN
Protein: Uncharacterized protein (Q385C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
- SCD domain-containing protein
- Sister chromatid cohesion protein
- Double-strand-break repair protein rad21 homolog, putative
- EF-hand domain-containing protein
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
- DNA polymerase eta
- RNA-binding protein
Sequence:
MPPKNNPKQHANVNGNHKLDSRPSNETGRPKREENKADDVVVPAGPTIKAQITNASKTSSGKTFLEALRTNVTKQTVRVEKPRTPEPPEVAVPEPEVPVAEEPTVEAVVAPVEIPPTPVEESPVVEKQPTPTPKPQQPPKPQPTVTLPESNGNFSWANDDDYTFSSDITPQHPVVPPQAKPVTYIVTYPAEVVEAHSKGPRVVFEAPASHQRIDSAMAELEKGRANLYNERHLFEECRKQREIEMNEKHARLLAQERQLNDQSDGLQRERSRLVEQQQQLQQQQQQQQQQQMIQQQPAPLRQAPSSLPVTSQTQLPPPPQPPQHVGNNYTYQTGTQDGMPWGGRGRNDHWTPNAGVMVPPYDHNHYYSGGHYLMQRNQNFGDRGVDVPPHMGRGNAMRGGPHMGGFSAGRPMGGADGGVNQMFGQRNSGGYMGGPALPNRW
Protein: Early E1A protein (Early E1A 27 kDa protein) (P10542)
Organism: Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
Function: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity).
Subcellular location: Host nucleus {ECO:0000250|UniProtKB:P03255}.
Interaction partners:
Sequence:
MRMLPDFFTGNWDDMFQGLLEAEHPFDFPEPSQAFEEISLHNLFDVELDESEGDPNEEAVDGMFPNWMLSEDHSADSGAASGDSGVGEDLVEVNLDLKCYEEGLPPSGSEADEAEERAEEEETAVSNYVNIAEGASQLVLDCPENPGRGCRACDFHRGSSGNPEAMCALCYMRLTGHCIYSPISDAEGECELGSNEETELPCSLTATAPVRPTPCRVSCRRRPAVDCIEDLLEEDPTDEPLNLSLKRPKSS
Protein: Arrestin-related trafficking adapter 10 (P18634)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Protein LDB19
- Arrestin-related trafficking adapter 3
- Protein ECM21
- Protein ROG3
- Transcription factor CSR2
- Arrestin-related trafficking adapter 5
- Ubiquitin ligase-binding protein BUL1
- Protein ROD1
- Arrestin-related trafficking adapter 6
Sequence:
MAPKISISLNPPYNGEFYSSNDQMSGIVSLQLTKALSIRKISVILKGFSETLTKIDQEYMFQQNGMMMPGQDNKSFHTLMKFEQRVFPPDNVWNALDGSSKPFKVKPGSYNYSFQFDKFPRKPECLKNHTAKTVAFVTRSNARLPPTFNSHWQEFNKIDNLDLYFYSFGKVIYMVQVQLELGKSSSWFKPFHKLIREIETFEFIPEPKDLIIEPDEDDNEELNAFSNNSRGNSMVTNNEFFNSSNLKVPSKDVKVVNGVGYIKSDRNFSQANSILIENGDIRSRPVSSVTSTRQSTRLVNGMKVFPSTYKMGLPDGESNMRIEVRSRDLKQIYRKDYLFRSGSQNFDKVYVVMEGNIASLSKMQITPLKLQLNLLETTTYLSQGIANGNYSSLKLIEIDLNQLKSNKPLLDLNEIRENFDGSMFECELRLKDHPILRKLVFNEEDYRHRGNRLYSFKTCTIKRTFSLQLLIEWGINGIRKQSEVNIDPVQIFCQVREHVEAEALPRYVPPPTYTEMAS
Protein: Hercynine oxygenase (EC 1.14.99.50) (Gamma-glutamyl hercynylcysteine S-oxide synthase) (A0R5N0)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N-acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine.
Interaction partners:
- Histidine N-alpha-methyltransferase
- Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase
- Glutamate--cysteine ligase EgtA
- Probable hercynylcysteine sulfoxide lyase
- Modulator of DNA gyrase
- Orotidine 5'-phosphate decarboxylase
- NAD
- Endonuclease IV
- Amidinotransferase
- Precorrin-4 C11-methyltransferase
Sequence:
MIARETLADELALARERTLRLVEFDDAELHRQYNPLMSPLVWDLAHIGQQEELWLLRDGNPDRPGMLAPEVDRLYDAFEHSRASRVNLPLLPPSDARAYCATVRAKALDTLDTLPEDDPGFRFALVISHENQHDETMLQALNLREGPPLLDTGIPLPAGRPGVAGTSVLVPGGPFVLGVDALTEPHSLDNERPAHVVDIPSFRIGRVPVTNAEWREFIDDGGYDQPRWWSPRGWAHRQEAGLVAPQFWNPDGTRTRFGHIEEIPGDEPVQHVTFFEAEAYAAWAGARLPTEIEWEKACAWDPVAGARRRFPWGSAQPSAALANLGGDARRPAPVGAYPAGASAYGAEQMLGDVWEWTSSPLRPWPGFTPMIYERYSTPFFEGTTSGDYRVLRGGSWAVAPGILRPSFRNWDHPIRRQIFSGVRLAWDV
Protein: Ferrienterobactin receptor (Enterobactin outer-membrane receptor) (P05825)
Organism: Escherichia coli (strain K12)
Function: This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D.
Subcellular location: Cell outer membrane {ECO:0000255|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU01360}.
Interaction partners:
- Protein TonB
- Enterobactin synthase component E
- Biopolymer transport protein ExbB
- Biopolymer transport protein ExbD
- Enterobactin synthase component B
- Iron
- Enterobactin synthase component F
- Ferric enterobactin-binding periplasmic protein FepB
- Isochorismate synthase EntC
- 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Sequence:
MNKKIHSLALLVNLGIYGVAQAQEPTDTPVSHDDTIVVTAAEQNLQAPGVSTITADEIRKNPVARDVSKIIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVSSRNSVRQGWRGERDTRGDTSWVPPEMIERIEVLRGPAAARYGNGAAGGVVNIITKKGSGEWHGSWDAYFNAPEHKEEGATKRTNFSLTGPLGDEFSFRLYGNLDKTQADAWDINQGHQSARAGTYATTLPAGREGVINKDINGVVRWDFAPLQSLELEAGYSRQGNLYAGDTQNTNSDSYTRSKYGDETNRLYRQNYALTWNGGWDNGVTTSNWVQYEHTRNSRIPEGLAGGTEGKFNEKATQDFVDIDLDDVMLHSEVNLPIDFLVNQTLTLGTEWNQQRMKDLSSNTQALTGTNTGGAIDGVSTTDRSPYSKAEIFSLFAENNMELTDSTIVTPGLRFDHHSIVGNNWSPALNISQGLGDDFTLKMGIARAYKAPSLYQTNPNYILYSKGQGCYASAGGCYLQGNDDLKAETSINKEIGLEFKRDGWLAGVTWFRNDYRNKIEAGYVAVGQNAVGTDLYQWDNVPKAVVEGLEGSLNVPVSETVMWTNNITYMLKSENKTTGDRLSIIPEYTLNSTLSWQAREDLSMQTTFTWYGKQQPKKYNYKGQPAVGPETKEISPYSIVGLSATWDVTKNVSLTGGVDNLFDKRLWRAGNAQTTGDLAGANYIAGAGAYTYNEPGRTWYMSVNTHF
Protein: [Trp5]-bradykinin (P84773)
Organism: Amia calva (Bowfin)
Function: Induces smooth muscle dilation and contraction. Intra-arterial injection induces a significant decrease in ventral aortic blood pressure of between 5 and 10 minutes duration followed by a dose dependent increase in ventral aortic blood pressure of between 30 and 60 minutes duration. May target bradykinin receptors (BDKRB).
Subcellular location: Secreted {ECO:0000269|PubMed:7651903}.
Interaction partners:
Sequence:
RPPGWSPFR
Protein: Putative high mobility group B2 protein (X2JGB1)
Organism: Cynoglossus semilaevis (Tongue sole)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MTKDPNRPRGKTSSYAFFVATCREEHKKKHPGTSVNFSEFSKKCSERWKTKSGKEKGKFEELAKNDKVRYEREMKTYVPPKGAKKGKKEKDPNAPKRPPSAFFVFCSDHRPRIKEEHPGISIGEIAKKLGELWSTQSSKDKAPYEAKAAKLKEKYEKEVAAYRAKSGTGKSDAGKKSGPGRPPKKAEPADDDDDDDDDEEEDDDDDDDDDDE