wanglab/gogpt-training-data huggingface dataset:
Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase 4 (Protein mannosyltransferase 4) (EC 2.4.1.109) (Q59X23)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P46971}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Erv29p
- Dolichol phosphate-mannose biosynthesis regulatory protein
Sequence:
MSQTLKKRGGNSSGRKSPTTSNIEFDDKKTEFDLNAIVPPKEPEYKYLAALTLVTLLAIYTRFTKLGTPNKVVFDEVHFGKFASYYLERTYFFDLHPPFAKLLIAFVGWLIGYDGKFKFEAIGDSYIENNVPYIAYRSLSAIQGAAIVPIMFLTMKTLGFSVAACLFSSIIVCFDNAQVTDSRLILLDATLILSVALTIFSYSKFSTFRKQSFSSKWWTWLLATGVSLSCVISTKYVGVFTYLTIGIAVIHELWILLDYRKGLTLQEFAKHFFARLWALIIVPFCIYLYWFYLHFAILTRSGPGDAFMSSEFQETLLESPLAAHSKPVQYFDQITIKHKDTGAFLHSHQHEYPLRYEDGRISSNGQQVTCVVQENAANDPNNQWEIVPTSEGANKGTKVYTNDIVRFRHVGTGGYLLTHDVASPLKPTNEEFTVVYDDVAQQRYNETLFRLRLHVPGSNPKKEKNKKEIKTLATDLRILHVDTVVAMWTHNDELLPEWAFNQQEVSGNKKIPDKDNIWNFDLITNLQSTDPRNQYVPKKVKTLPFLRKWWELQMLMFHHNNQLSSEHPFATQPGEWPLALSGVSFYNDNTEKKQIFFIGNIIGFWLEVCFLSIYIGILLADQITRRRNVHVLSDRARSRLYNTLGFLFVGWAAHYLPFFLMNRQKFLHHYLPAHLVAALFSGGLVEFICSNNSARPNGKPVGVNKYKIIAVVAACSTAIIWFFFYFRPLTYGDVYLTPEEVKARQWLDIKLHYGK
Protein: Gap junction alpha-3 protein (Connexin-46) (Cx46) (Q64448)
Organism: Mus musculus (Mouse)
Function: Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9TU17}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9TU17}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q9TU17}.
Interaction partners:
- Gap junction gamma-1 protein
- Gap junction alpha-8 protein
- Gap junction alpha-5 protein
- Gap junction beta-2 protein
- Gap junction alpha-4 protein
- Gap junction alpha-1 protein
- Beta-crystallin B1
- Beta-crystallin B2
- Gap junction beta-1 protein
- Gamma-crystallin S
Sequence:
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEELLRRDNPQHGRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFQLQPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVACASLVLNMLEIYHLGWKKLKQGVTNHFNPDASEARHKPLDPLPTATSSGPPSVSIGFPPYYTHPACPTVQAKAIGFPGAPLSPADFTVVTLNDAQGRNHPVKHCNGHHLTTEQNWTRQVAEQQTPASKPSSAASSPDGRKGLIDSSGSSLQESALVVTPEEGEQALATTVEMHSPPLVLLDPGRSSKSSNGRARPGDLAI
Protein: Protein NipSnap homolog 1 (NipSnap1) (O55125)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9BPW8}.
Interaction partners:
- Microtubule-associated protein 1 light chain 3 beta
- Tax1-binding protein 1 homolog
- Calcium-binding and coiled-coil domain-containing protein 2
Sequence:
MAPRLCIISAAARRLFTKPRPRAGDLAAAGAVRFYSKDSEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPECLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRKERSKMLLSRRNQLLLEFSFWNEPQPRAGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
Protein: Transthyretin (Prealbumin) (THBP) (Tadpole T3-binding protein) (T-T3BP) (P31779)
Organism: Aquarana catesbeiana (American bullfrog) (Rana catesbeiana)
Function: Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain.
Subcellular location: Secreted {ECO:0000269|PubMed:8477670}.
Interaction partners:
Sequence:
MAYYNTLALLTIFIFSGAFHRAQGTHGEADSKCPLMVKVLDAVRGIPAAKLPVKVFKQNEDKSWDLISSGTTSSDGEIHNLATEEQFVEGIYKLEFATKRFWSKLGLTPFHEYVDVVFTANDAGHRHYTTAVLLTPYSFSTTAVVSDVKEAHV
Protein: Uncharacterized protein, isoform B (Q86BN2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPGRKARRKLIKKQQRKRRRQKHAKERDKLEEEAENQRLMQPEYQKWSQEQEEMQEFQRLADERERQLAEESWLRREATAQRQFQMDEAKKRQEQEEVERLQREQAKERAEREERQRKQREEETRKAAKAAAEFDAMMESMDEYLNNPRIEKPPSHLLRVMETHPEERACEFFSRTNCCRYGHACTFNHRRPMLGRILLIRHFFNHSMLQKRCTHKEYASAEEHLELTEQDLRHDYDEFFNDVVEELRKFGTIVNFRTVRNTLEHLRGHVFVEYTNERSALRAFTNLQGRYYASKRLNVEFSNLRTWRGAVCGT
Protein: At5g52190 (Sugar isomerase (SIS) family protein) (Q9LTK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANEKAQEMANLSSQICNQISSVFTKPTSPYPPPLDLLVTELTAISRNRNNSRIFLYGVGREGLMLKAFAMRLFHFGLPTHLVFDMTTPPISSSDLLIASAGPGGFSTVDALCSVAKSNGAKVILITAEPAIGSCVKHATDVCYVPAQTMASDNGGGDSVEMGERRLLPMGSVYEGALFVLFEMVVYKLGEVLGESSESVRARHTNLE
Protein: Ribosome production factor 1 (Ribosome biogenesis protein RPF1) (P38805)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential protein. Required for biogenesis of the 60S ribosomal subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11864606, ECO:0000269|PubMed:12702244}.
Interaction partners:
- ATP-dependent RNA helicase HAS1
- Ribosome biogenesis protein 15
- Ribosome biogenesis protein RLP7
- Pescadillo homolog
- 25S rRNA
- Protein MAK16
- Nucleolar complex protein 2
- rRNA-processing protein EBP2
- Proteasome-interacting protein CIC1
- Ribosomal RNA-processing protein 15
Sequence:
MALGNEINITNKLKRQEIFADIKHEKNKERHTMRRKRAKEERENPELREQRLKENVTQTIENTRVYDETINKEVEGDEDDLMRYFNSNSNEPPKIFLTTNVNAKKSAYEFANILIEILPNVTFVKRKFGYKLKEISDICIKRNFTDIVIINEDKKKVTGLTFIHLPEGPTFYFKLSSFVEVKKIVGHGRPTSHIPELILNNFQTRLGQTVGRLFQSILPQNPDIEGRQVITLHNQRDYIFFRRHRYVFKDNERVGLQELGPQFTLKLKRLQRGIKEETEWEHKPEMDKEKKKFYL
Protein: Acetolactate synthase small subunit, mitochondrial (Acetohydroxy-acid synthase small subunit) (AHAS) (ALS) (P25605)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of mitochondrial acetolactate synthase, which catalyzes the first of a series of common steps in the biosynthesis of the branched-chain amino acids. Stimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:10213630}.
Interaction partners:
- Acetolactate synthase catalytic subunit, mitochondrial
- Ketol-acid reductoisomerase, mitochondrial
- Threonine dehydratase, mitochondrial
- 2-hydroxyacyl-CoA lyase
- 3-isopropylmalate dehydrogenase
- Catabolic L-serine/threonine dehydratase
- Dihydroxy-acid dehydratase, mitochondrial
- 2-isopropylmalate synthase
- 3-isopropylmalate dehydratase
- 2-isopropylmalate synthase 2, mitochondrial
Sequence:
MLRSLLQSGHRRVVASSCATMVRCSSSSTSALAYKQMHRHATRPPLPTLDTPSWNANSAVSSIIYETPAPSRQPRKQHVLNCLVQNEPGVLSRVSGTLAARGFNIDSLVVCNTEVKDLSRMTIVLQGQDGVVEQARRQIEDLVPVYAVLDYTNSEIIKRELVMARISLLGTEYFEDLLLHHHTSTNAGAADSQELVAEIREKQFHPANLPASEVLRLKHEHLNDITNLTNNFGGRVVDISETSCIVELSAKPTRISAFLKLVEPFGVLECARSGMMALPRTPLKTSTEEAADEDEKISEIVDISQLPPG
Protein: Importin-13 (Imp13) (Late gestation lung 2 protein) (Q9JM04)
Organism: Rattus norvegicus (Rat)
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- GTP-binding nuclear protein Ran
- Importin subunit beta-1
- Importin subunit alpha
- Importin subunit alpha
- Importin subunit alpha
- Exportin-5
- SUMO-conjugating enzyme UBC9
- RNA-binding protein 8A
- Importin subunit alpha-5
- Snurportin-1
Sequence:
MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAHSFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRASLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYELPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEENLKNLHSLISTYIQQLEKLAEEIPKPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLSDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFQCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY
Protein: PhoH-like protein (P0A9K3)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Endoribonuclease YbeY
- Apolipoprotein N-acyltransferase
- Magnesium and cobalt efflux protein CorC
- ATP-dependent Clp protease ATP-binding subunit ClpX
- tRNA-2-methylthio-N
- Ribonuclease R
- UPF0250 protein YbeD
- RNA-binding protein Hfq
Sequence:
MNIDTREITLEPADNARLLSLCGPFDDNIKQLERRLGIEINRRDNHFKLTGRPICVTAAADILRSLYVDTAPMRGQIQDIEPEQIHLAIKEARVLEQSAESVPEYGKAVNIKTKRGVIKPRTPNQAQYIANILDHDITFGVGPAGTGKTYLAVAAAVDALERQEIRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTIEQMKMFLTRIGFNSKAVITGDVTQIDLPRNTKSGLRHAIEVLADVEEISFNFFHSEDVVRHPVVARIVNAYEAWEEAEQKRKAALAAERKREEQEQK
Protein: Nuclear receptor coactivator 5 (B5X221)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MAAERQRQNKAQSRPSPPRRDPYGGYGEGREPRPRSRSPMHGRDSRAHRGSREHSREPGREPRHPRDHHEPRDPNFDRYRTPEGRDKDLRGEPRGEPRGDPRDPTFREEGYDRYYRGGADEHHRKKDDPYRDPWNGRREPEGKDDRVRVEERRRNELYRQYYEEVQRQYDRERPVDCSVIVVNKAQNREYAETVGRKVRDLGMVVDLIFLNTEVSLTQALEDVGRARTPFAIIITQQHQVHRSCTVNILFGTPQEHRNMPMEDAMVLVGHNYDSFKVEHREKEREEIAQKAAKMADDVLMREHEREGHPVTLLPAITLLSEGRFLTPEELDSLIEYLRVKRERIVRADPLAAVHPPATAATHDPPLQAQTMPPAVHPGHAPPPHSAHSTHMSMPPAPNATNNQQELQAKILSLFNSGAGASASAASPAMVPQSYGSTMGIQSTGLPMSSASPVPKMAPTPSQVPNMMGARPPMRPGPVPLGIHQGYGSPTGRMAAPQGGQRPPVSGGAGINFDNPSVQKALDTLIQSGPSLNHLVNAGNSASPRPSHGMGQGMGQNMGQGMGQGMGQGMGQPPPMAMYPRHY
Protein: Nucleoporin seh1 (GATOR complex protein seh1) (Nucleoporin complex protein 44A) (Q7K2X8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells. It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:21521741}. Lysosome {ECO:0000269|PubMed:25512509}. Note=Enriched on the nuclear envelope of nurse cells, oocytes and syncytial embryos (PubMed:21521741). In egg chambers detected in lysosomes and autolysosomes of both fed and starved females (PubMed:25512509). {ECO:0000269|PubMed:21521741, ECO:0000269|PubMed:25512509}.
Interaction partners:
- Nucleoporin Nup37
- GATOR2 complex protein Wdr59
- Nuclear pore complex protein Nup160 homolog
- Nuclear pore complex protein Nup98-Nup96
- Nucleoporin 43kD
- GATOR complex protein NPRL2
- Protein SEC13 homolog
- GATOR2 complex protein Mio
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup75
Sequence:
MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSWAHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTRRWVRRTTLVDSRTSVTDVEFAPKYLGLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWNTSTYMVTQLLAAGSDEAATPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYIVNLRGVTDATDISKLDIQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQWRCAAVLKAEGSGPTYEPAPPTPTLATTASATAKFYKKGTIGNQVPWH
Protein: Legumain (EC 3.4.22.34) (Protease, cysteine 1) (Q6NYJ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSPKTVAVLGLALSLGLVVSGFPAEQPENGKHWVVIVAGSNGWYNYRHQADVCHAYQIVHKNGIPDEQIVVMMYDDLAESPDNPTKGVVINRPNGSDVYKGVLKDYIGDDVTPENFLAVLKGDAASVKGGSGKVLKSGPNDHVFVYFTDHGAPGLLAFPNDDLHVDDLMDTIKYMHSNNKYKKMVFYVEACESGSMMKPLPVDINVYATTAANPDESSYACYYDEARDTYLGDWYSVNWMEDSDVEDLSKETLAKQFKIVKAKTNTSHVMQYGNKTLSHMKVMAFQGSSKGLDKAVEPVSLPVIAEHDLMSSPDVPLAILKRKLQKTNDVDAVVGYLNEIHAHLQVRELLGNTMRKIVEHVVQDKEEVQDYLDGRSDLTQYNCYKTAVRHYKKHCFNWHEQKFEYALRHLYALVNLCEGGYQAHRITAAMDDVCYFRD
Protein: Diamond (LP22035p) (E2QCZ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQELKQRFERRQLADDLKQKQVIQDHLLQKILYSKRLLVDHVEALEHCMQELQTASSASSGRQLLTTRNACLILGGTLLEHLITPRGIRYTMVPSILISGTFAALFAVKSVFVCRNKIVERKLEQLVKTIDEFGNCIRRNMTYFQEIIIMKQAELIESRQIERAWDCITAAKEVTEILYDATRKLETDYPLPTKYSAYYAPMEELRECEYFKNNVTDYSPKHIKDFHNIFAYVQSQYLLRLALTITTRPSISQLSEDLVKIDSLVRQLVQEEEQHFSNLALALQNKKQLELAELNATRAEQQQSGPIAVLQHSSLKLSACMVAVAAECQALDVTLQKLTVTEAAKKNNSKELVAVANNMHGIENALAVCCDDFQRLMLVYNKFLHSQLDLEGELPKPKQDLDDEFPESILRVEFSQNVDAPQQRDDFYAYMYDENEEQHFEAEQNAPFPSPEKELLNFEKRITKGRFKPVLKQLKDRIDPIRQVMLEKEREVLASKGINVDELFGKMERVEQQQEDNRLADAAPLPVYESSSNSDSDSADEEAFRRRSKQHKERDNFAEMRQFLAQKQAINLFKLPPPPVAAGGEELLESEC
Protein: Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1) (A0A5H1ZRR1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic granule {ECO:0000256|ARBA:ARBA00004463}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRSHEKLDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKAVSRKDEELDPMDPSSYSDAP
Protein: Rifin (Q8I3D6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLLHYCKVLLFSLPLNILVHNKNKLYITPQHTRTNRLLCECELYTPIYDDDPEMKKVLHDFDRQTSQRFKEYNERMQEKLKKCKEQCDKDIQKIILKDKIEKQMVDKFSALETNIDSNDIPTCICKKTLADKVEKSCLKCTQNLGGIVTPSSVVLGGIAELGLSAWKTTALKVAIEAAKEAGAAKGLAKVQAMGFANFFEGMKSGFCIKELDIKLLKAVFIQQKRENFTKLAHSIYVQYNNKCGLAVAKNSYHTCNFGKALKCTELCSQANCSNEATIADGVNKILSTAKSAAANETANVIASETAAIEATKKGAIETTCMNCHTAIIASIVAIVIIVMVMVIIYLILR
Protein: Repressor of RNA polymerase III transcription MAF1 (P41910)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC3
- Serine/threonine-protein kinase SCH9
- DNA-directed RNA polymerase III subunit RPC6
- Transcription factor IIIB 70 kDa subunit
- DNA-directed RNA polymerase III subunit RPC4
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC7
Sequence:
MKFIDELDIERVNQTLNFETNDCKIVGSCDIFTTKAVASDRKLYKTIDQHLDTILQENENYNATLQQQLAAPETNQSPCSSPFYSNRRDSNSFWEQKRRISFSEYNSNNNTNNSNGNSSNNNNYSGPNGSSPATFPKSAKLNDQNLKELVSNYDSGSMSSSSLDSSSKNDERIRRRSSSSISSFKSGKSSNNNYSSGTATNNVNKRRKSSINERPSNLSLGPFGPINEPSSRKIFAYLIAILNASYPDHDFSSVEPTDFVKTSLKTFISKFENTLYSLGRQPEEWVWEVINSHMTLSDCVLFQYSPSNSFLEDEPGYLWNLIGFLYNRKRKRVAYLYLICSRLNSSTGEVEDALAKKPQGKLIIDDGSNEYEGEYDFTYDENVIDDKSDQEESLQ
Protein: CYtochrome P450 family (G5EGT6)
Organism: Caenorhabditis elegans
Interaction partners:
- NADPH--cytochrome P450 reductase
- Fatty acid synthase
- Fatty acid synthase
- Nematode cuticle collagen N-terminal domain-containing protein
Sequence:
MGVIIPAVLLAMATVIAWLLYKHLRMRQVLKHLNQPRSYPIVGHGLITKPDPEGFMNQVIGMGYLYPDPRMCLLWIGPFPCLMLYSADLVEPIFSSTKHLNKGFAYVLLEPWLGISILTSQKEQWRPKRKLLTPTFHYDILKDFLPIFNEQSKILVQKLCCLGADEEVDVLSVITLCTLDIICETSMGKAIGAQLAENNEYVWAVHTINKLISKRTNNPLMWNSFIYNLTEDGRTHEKCLRILHDFTKKVIVERKEALQENDYKMEGRLAFLDLLLEMVKSGQMDETDVQAEVDTFMFEGHDTTSTGLMWAIHLLGNHPEVQRKVQAELDEVMGDDEDVTIEHLSRMKYLECALKEALRLFPSVPIITRELSDDQVIGGVNIPKGVTFLLNLYLVHRDPAQWKDPDVFDPDRFLPENSIGRKSFAFIPFSAGSRNCIGQRFALMEEKVIMAHLLRNFNIKAVELMHEVRPKMEIIVRPVTPIHMKLTRRRPIVSP
Protein: Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12) (Q64291)
Organism: Mus musculus (Mouse)
Function: Involved in corneal epithelium organization, integrity and corneal keratin expression.
Interaction partners:
- Keratocan
Sequence:
MSLSVCTSALSRRSSSQNGAAGRPWGASASSVAGGYGGSASGFGVGCGGLFSAASMFGSSSGFSGGSAGCLPGLGSAYGGPLRGGAGGMGIGMGIAGSSGGGSLCIFSGNDGGLLSGSEKETMQNLNDRLASYLGKVRSLEEANAELENKIREWYETRRTRDAGSQSDYSKYYPLIEDLKNKIVSARVSNAQLLLQIDNARLAAEDFRMKYENELALRQTVEADINGLRRVLDELTLTRADLEAQLETLTEELAYMKKNHEEELQSFQAGGPGEVNVEMDAAPGVDLTKVLNEMRAQYEAMAEQNRKDAEAWFLEKSGELRKEISSNTEQLQSSKSEVTDLKRMVQNLEIELQSQLAMKSSLEGSLAETEGGYCCQLSQVQQLIGSLEEQLQQVRADAERQNADHQRLLGVKARLEMEIETYRRLLEGDSQGDGFDESSSLSVSKPQTPSVDSSKDPNKTRKIKTVVQEIVNGEVVSSQVQELEEEM
Protein: UDP-glucuronosyltransferase 2B28 (UDPGT 2B28) (UGT2B28) (EC 2.4.1.17) (Q9BY64)
Organism: Homo sapiens (Human)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption. Displays glucuronidation activity toward the phenolic compounds eugenol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11300766}.
Interaction partners:
- Cytochrome P450 3A4)
- Cytochrome P450 2D6
- Cytochrome P450 2A6
- Cytochrome P450 1A1
- Cytochrome P450 3A5
- Cytochrome P450 2E1
- Beta-glucuronidase
- Aldehyde oxidase
- Cytochrome P450 2A13
- UDP-glucose 6-dehydrogenase
Sequence:
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q7ZW18)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
Sequence:
MENAHTKSVEEVYSNFSVNESTGLTLDQVKRNRDKWGPNELPAEEGKSIWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEVAVGDKVPADIRISAIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAIGVVVATGVNTEIGKIRDEMASTEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFIIDKAEGENCSLTEFTISGSTYAPEGDVCLDNRIVKCSQYDGLVELATICALCNDSSLDFNESKGVYEKVGEATETALTCLVEKMNVFDTDVRNLSKIERANACNAVIKQLMKKEFTLEFSRDRKSMSVYCSPNKAKSSSSKMFVKGAPEGVIDRCAYVRVGGSKVPLTQGIKDKIMSVIREYGTGRDTLRCLALATRDNPLKKEEMVLSDTARFADYESDLTFVGCVGMLDPPRTEVAASIKLCRHAGIRVIMITGDNKGTAVAICRRIGIFSDDDDVHRMAFTGREFDDLSPHAQREAVTVARCFARVEPSHKSKIVEFLQGFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRSAKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIVADDGPMITLYQLSHFLQCSPDNPDFQDLECHVFESPYPMTMALSVLVTIEMCNALNSLSENQSLVRMPPWENIWLLGAICLSMSLHFLILYVEPLPVIFQITPLNVTQWMMVLKISLPVILLDELLKFVARTYLEPAPED
Protein: Sodium-dependent nutrient amino acid transporter 1 (B4R4T6)
Organism: Drosophila simulans (Fruit fly)
Function: Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GD14514
Sequence:
MELKGVQPSNGSPNGNGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPEEYVDNLLTGVSLANESARNLSGIGLVANNETEKLQSSSELYFLNVVIKEKLDISDGVGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYWKVALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMATIEPIKYSELYFPEAANVAGWLLFAIGAAQFPLWGLWYASRHPQGTYWKSLKASLKPSDRWGPANPETRREWVIFKNQKAPQRATQKDTSKLGFFWRKIANFCGSNK
Protein: DDB1- and CUL4-associated factor 7 (Ddb1 and cul4-associated factor 7) (WD repeat domain 68) (Q7T3E0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- dual-specificity kinase
- Cullin-4B
- Cullin 4A
- Dual-specificity tyrosine-
- Damage-specific DNA-binding protein 1.
- Homeodomain-interacting protein kinase 2.
- non-specific serine/threonine protein kinase
- Dual-specificity tyrosine-
- non-specific serine/threonine protein kinase
- dual-specificity kinase
Sequence:
MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLEEESSEFVCRNTFDHPYPTTKIMWIPDTKGVYPDLLATSGDYLRIWRVNDTETRLECLLNNNKNSDFCAPLTSFDWNEVDPNLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV
Protein: Uncharacterized protein, isoform C (Q8IQ01)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MADNAVQAQPNGLGPQKQKALELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQGVTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIIDDIIDILQLQSCRRTLVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICHLQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQYYNPADFGIPGSVQSVLHHRTL
Protein: Uncharacterized protein At4g13200, chloroplastic (Q8LDV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16461379, ECO:0000269|PubMed:22274653}.
Interaction partners:
- Probable plastid-lipid-associated protein 9, chloroplastic
Sequence:
MSSFTIPSPSSFSLSNSYNQTSPHSFTLRNSRSNFEFHRLRLDVESRRRSTSLRSNCSTKGTDSGENENKSVLDAFFLGKALAEVINERIESTVGEVLSTIGKFQAEQQKQVQEIQEEVLERAKKAKERAARETMEEQGLVASKPVAITRNPDAVVVASVTSTSTVESKTIMVDVEESSSSSDED