wanglab/gogpt-training-data huggingface dataset:
Protein: Collagen alpha-1(IV) chain [Cleaved into: Arresten] (P02463)
Organism: Mus musculus (Mouse)
Function: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:24368846}.
Interaction partners:
- Collagen alpha-2
- Collagen, type IV, alpha 6
- CD44 antigen
- Col4a5 protein
- Collagen alpha-4
- Collagen alpha-3
- Platelet glycoprotein VI
- Integrin beta-1
- Integrin alpha-5
- Collagen alpha-1
Sequence:
MGPRLSVWLLLLFAALLLHEERSRAAAKGDCGGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPHGPPGQKGDAGEPGLPGTKGTRGPPGAAGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFSGNPGPPGLPGMKGDPGEILGHVPGTLLKGERGFPGIPGMPGSPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGSSFQGPKGDKGEQGVSGPPGVPGQAQVKEKGDFAPTGEKGQKGEPGFPGVPGYGEKGEPGKQGPRGKPGKDGEKGERGSPGIPGDSGYPGLPGRQGPQGEKGEAGLPGPPGTVIGTMPLGEKGDRGYPGAPGLRGEPGPKGFPGTPGQPGPPGFPTPGQAGAPGFPGERGEKGDQGFPGVSLPGPSGRDGAPGPPGPPGPPGQPGHTNGIVECQPGPPGDQGPPGTPGQPGLTGEVGQKGQKGESCLACDTEGLRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGLEGLPGPQGSPGLIGQPGAKGEPGEIFFDMRLKGDKGDPGFPGQPGMPGRAGTPGRDGHPGLPGPKGSPGSIGLKGERGPPGGVGFPGSRGDIGPPGPPGVGPIGPVGEKGQAGFPGGPGSPGLPGPKGEAGKVVPLPGPPGAAGLPGSPGFPGPQGDRGFPGTPGRPGIPGEKGAVGQPGIGFPGLPGPKGVDGLPGEIGRPGSPGRPGFNGLPGNPGPQGQKGEPGIGLPGLKGQPGLPGIPGTPGEKGSIGGPGVPGEQGLTGPPGLQGIRGDPGPPGVQGPAGPPGVPGIGPPGAMGPPGGQGPPGSSGPPGIKGEKGFPGFPGLDMPGPKGDKGSQGLPGLTGQSGLPGLPGQQGTPGVPGFPGSKGEMGVMGTPGQPGSPGPAGTPGLPGEKGDHGLPGSSGPRGDPGFKGDKGDVGLPGMPGSMEHVDMGSMKGQKGDQGEKGQIGPTGDKGSRGDPGTPGVPGKDGQAGHPGQPGPKGDPGLSGTPGSPGLPGPKGSVGGMGLPGSPGEKGVPGIPGSQGVPGSPGEKGAKGEKGQSGLPGIGIPGRPGDKGDQGLAGFPGSPGEKGEKGSAGTPGMPGSPGPRGSPGNIGHPGSPGLPGEKGDKGLPGLDGVPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEQGVPGRGFPGFPGSKGDKGSKGEVGFPGLAGSPGIPGVKGEQGFMGPPGPQGQPGLPGTPGHPVEGPKGDRGPQGQPGLPGHPGPMGPPGFPGINGPKGDKGNQGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGLPGVPGFQGQKGLPGLQGVKGDQGDQGVPGPKGLQGPPGPPGPYDVIKGEPGLPGPEGPPGLKGLQGPPGPKGQQGVTGSVGLPGPPGVPGFDGAPGQKGETGPFGPPGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTTDDPLCPPGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPISGDNIRPFISRCAVCEAPAMVMAVHSQTIQIPQCPNGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT
Protein: von Hippel-Lindau disease tumor suppressor (pVHL) (Q64259)
Organism: Rattus norvegicus (Rat)
Function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P40337}. Cell membrane {ECO:0000250|UniProtKB:P40337}; Peripheral membrane protein {ECO:0000250|UniProtKB:P40337}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P40337}. Nucleus {ECO:0000250|UniProtKB:P40337}. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane. {ECO:0000250|UniProtKB:P40337}.
Interaction partners:
- Elongin-B
- E3 ubiquitin-protein ligase RBX1
- Cullin 2
- Elongin-B
- Elongin-C
- Hypoxia-inducible factor 1-alpha
- Endothelial PAS domain-containing protein 1
- Hypoxia-inducible factor 3-alpha
- Egl nine homolog 1
- Prolyl hydroxylase EGLN3
Sequence:
MPRKAASPEEAERMPGSEEIEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVRKDIQRLTQEHLENQALGEEPEGVH
Protein: ORF6 protein (Accessory protein 6) (Non-structural protein 6) (A0A3G5BIZ0)
Organism: SARS coronavirus Urbani
Subcellular location: Host Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004217}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004625}.
Interaction partners:
Sequence:
MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP
Protein: Secreted effector protein (A0A0F6B063)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Interaction partners:
Sequence:
MPITIGNGFLKSEILTNSPRNTKEAWWKVLWEKIKDFFFSTGKAKADRCLHEMLFAERAPTRERLTEIFFELKELACASQRDRFQVHNPHENDATIILRIMDQNEENELLRITQNTDTFSCEVMGNLYFLMKDRPDILKSHPQMTAMIKRRYSEIVDYPLPSTLCLNPAGAPILSVPLDNIEGYLYTELRKGHLDGWKAQEKATYLAAKIQSGIEKTTRILHHANISESTQQNAFLETMAMCGLKQLEIPPPHTHIPIEKMVKEVLLADKTFQAFLVTDPSTSQSMLAEIVEAISDQVFHAIFRIDPQAIQKMAEEQLTTLHVRSEQQSGCLCCFL
Protein: Cochlin (COCH-5B2) (Q62507)
Organism: Mus musculus (Mouse)
Function: Plays a role in the control of cell shape and motility in the trabecular meshwork.
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:O43405}.
Interaction partners:
- Choline transporter-like protein 2
- Ubiquitin-like protein FUBI
Sequence:
MPSSRIPALCLGAWLLLLLLPRFARAEGAVPIPVTCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFAVTKGKSSTQEATGRAVSTAHPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYNTKENVLAVLANIRYMSGGTATGDAIAFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLRDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ
Protein: DNA polymerase I A, chloroplastic (EC 2.7.7.7) (DNA polymerase PolI-like A) (OsPolI-like A) (DNA polymerase gamma 1) (Q6Z4T5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). May be required for DNA replication and accumulation in plastids.
Subcellular location: Plastid, chloroplast {ECO:0000305|PubMed:11917019}.
Interaction partners:
- Os07g0154400 protein
- Os04g0637400 protein
- Exonuclease 1
- Os01g0685500 protein
- Fanconi-associated nuclease 1 homolog
- Os03g0205400 protein
- Double-strand break repair protein MRE11
- Double-strand break repair protein MRE11
- Chlorophyll a-b binding protein
- Flap endonuclease 1-B
Sequence:
MAVAPPLPPAPARQLRRWKGSSPRPPPWLSSPFRRTRYLSRPAFAAGGRQDYSPSSGMGVSKTGAFRLGLYGNLNVQSSVQEWVDETKRLFFLRTTNSVRNNITNGTTPLRVGNLRHDPSEDIRSSNYPSLYNQRERGPSNSIVNRHVDTDLAKHRVMYQSAHAVPAPFSVVNNDIKPLNMLDGSKEEIPWHDSVTMESSLPKVSKSEKTLVVDKAIPDKKEHKRITRKVTPNFPDKASLSTESKNARKLLATIYDKVLVVDNVESARSVVKLLTTKYKGFIHACDTEVANIDVKEETPVGHGEVICFSICSGNSDGEADFGNGKTCIWVDVLDGGRDVLMEFAPFFEDPFIKKVWHNYSFDIHVIENCGIKVAGFHADTMHLARLWDSSRRTDGGYSLEGLTNDYRVMDAVLKDIPKTGKVSMKTIFGRKKVRKDGSEGKTISIEPVEKLQREDRELWICYSSLDSMSTLKLYESLKNKLEAKEWIFDDCPRGTMYDFYEEYWRPFGALLVKMETEGVLVDRAYLSEIEKAAVTERELAADKFRKWASKHCPDAKYMNVNSDNQIRQLFFGGIENRNKRGETWPQSKTFKVPNDEGIATEGKKTPKSRTIKLFTIVEDLKIDMFTPTGWPSVSGDVLRSLAGKIPTDHIYKIDDGQEFDEDGSSLELPEQDIEDTSPYGTAYEAFGGGKKGREACHAIAALCEVFSIDKLISGFIVPLQGDRISCKEGRIHCSLNINTETGRLSARTPNLQNQPALEKDRYKIRHAFVAAPGNTLIVADYGQLELRILAHLTNCKSMLEAFKAGGDFHSRTAMNMYQHVRDAVEEKKVLLEWHPQPGQDKPPVPLLKDAFGAERRKAKMLNFSIAYGKTAVGLSWDWKVSVREARDTLKLWYRDRKEVSAWQKKQKAFALEKCEVYTLLGRSRQFPNMTHAGPGQKGHVERAAINAPVQGSAADVAMCAMLEIERNARLKELGWRLLLQVHDEVILEGPTESAEEAKTIVVECMSKPFYGTNILKVDLAVDAKYAKSWYAAK
Protein: ETS proto-oncogene 2, transcription factor (A0A590UJP9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004019}.
Interaction partners:
Sequence:
MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFPKSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGVCGTPRAWPPSLLGPVPCFLSSHSTTFTEGVSKLGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
Protein: Baculoviral IAP repeat-containing protein 5.2-B (Survivin in Xenopus) (SIX) (Survivin2-B) (XSurvivin2B) (Q804H7)
Organism: Xenopus laevis (African clawed frog)
Function: Does not appear to exhibit anti-apoptotic activity. Plays a role in increasing blood vessel size during development (By similarity). Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O15392}. Nucleus {ECO:0000250|UniProtKB:O15392}. Chromosome, centromere {ECO:0000250|UniProtKB:O15392}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. {ECO:0000250|UniProtKB:O15392}.
Interaction partners:
Sequence:
MLSISPIVSLRRCDNEPSMPDEWRLYNLATRLRTFSNWPFTEDCACTPERMAEAGFVHCPTDNSPDVVKCFFCLKELEGWQPEDDPMDEHKKHSPSCLFIALKKKAEELTLSEFLKLDLEHMKIKMQKQMNLHIERFQAKANEVRGHLEKLDADETQ
Protein: BcDNA.GH08860 (RE05454p) (Trehalose-6-phosphate synthase 1 (EC 2.4.1.15, EC 3.1.3.12)) (Q9Y119)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Trehalase
- Trehalase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen [starch] synthase
- Trehalose 6-phosphate phosphatase
- Trehalose 6-phosphate phosphatase
- Glycogen phosphorylase
- Glucose-6-phosphate isomerase
- Delta-1-pyrroline-5-carboxylate synthase
- Cytochrome b5-related protein
Sequence:
MPDTEIIVTNAGEPSTKASLIVVSNRLPFVLIRDPKTDELERRASAGGLVTAVCPVVIKGSGLWVGWSGIHLKDPNEAIPESNPNDQTPTAGLKSEQVVSVNIDSKIFDSYYNGCCNKIFWPLFHSMPGRANFGGEHWHDYVTVNKHFAVRTIEALEKCLAKNQGSEKSPPIVWIHDYHLMLAANWVREHAEEKNLPCRLAFFLHIPFPPWDIFRLLPWSDEILQGMLGCDLVGFHIQDYCLNFVDCCQRNLGCRVDRNNLLVEHGGRTVRVRPLPIGIPYERFVNLATTAPKVLKTSKMQIILGVDRLDYTKGLVHRLMAFEALLLKYPQHKEKVSLLQISVPSRTDVKEYRELKEEVDQLVGRINGRFTTANWAPIRYIYDYVSQDELAALYRDAAVCLVTPLRDGMNLVAKEFVACQINEVPGVLVISPFAGAGEMMHEALLCNPYEVNEAAEVIHRALTMPEDERVLRMARLRRREAECDVSHWMRCFLKAVGALEMDDVGTTIMQPVSVDDFDDYLLKYIGYNHKLALLLDYDGTLAPIAPHPDLATLSPEIKNVLYKLSNHSDVYVAVISGRNVDNVKKMVGIEGITYAGNHGLEILHPDGSKFVHPMPMEYEKKVSDLLKALQDSVCRDGAWVENKGALLTFHYRETPNHLRGAMVDKARSLIEKYGFKATEAHCALEARPPVQWNKGRASIYILRTSFGVDWNERIKIIYVGDDLTDEDAMVALKGMARTFRVTSSDIVKTAADHRLPSTDSVYTLLKWVERHFMGRKARANSLTYRPTKGDGVQMQMSLEVAASANNLEV
Protein: Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16) (P43028)
Organism: Mus musculus (Mouse)
Function: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q6KF10}.
Interaction partners:
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
- Noggin
- Activin receptor type-2B
- Activin receptor type-2A
- Chordin
- Bone morphogenetic protein receptor type-2
- Neuroblastoma suppressor of tumorigenicity 1
- Anti-Muellerian hormone type-2 receptor
- Gremlin-2
Sequence:
MDTPRVLLWAIFLISFLWDLPGFQQASISSSSSSSTELDSTKDVGNRKEGKMQRTPQESAEGRTPPEHGLRQKDLRRRPPGQHQGQEPPGRGLRVVPHEYMLSIYKTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVGAELRLYRQAPPTPWGLPARPLHLQLFPCLSPLLLDARTLDPQGPTQAGWEVFDVWQGLRPQPWKQLCLELRAAWGELDAGDTGARARGPQQPPPLDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGSPDAGSWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR
Protein: Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (Q4KTA7)
Organism: Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O14746}. Chromosome, telomere {ECO:0000250|UniProtKB:O14746}.
Interaction partners:
- Protection of telomeres protein 1
- H/ACA ribonucleoprotein complex subunit 3
- Shelterin complex subunit TPP1/Est3 domain-containing protein
- X-ray repair cross-complementing protein 5
- DNA helicase
- H/ACA ribonucleoprotein complex subunit DKC1
- Telomerase Cajal body protein 1
- Uncharacterized protein.
- H/ACA ribonucleoprotein complex subunit
- Telomerase-binding protein EST1A
Sequence:
MSITDLSPTLGILRSLYPHVQVLVDFADDIVFREGHKATLIEESDTSHFKSFVRGIFVCFHKELQQVPSCNQICTLPELLAFVLNSVKRKRKRNVLAHGYNFQSLAQEERDADQFKLQGDVTQSAAYVHGSDLWRKVSMRLGTDITRYLFESCSVFVAVPPSCLFQVCGIPIYDCFSLATASLGFSLQSRGCRERCLGVNSMKRRAFNVKRYLRKRKTETDQKDEARVCSGKRRRVMEEDKVSCETMQDGESGKTTLVQKQPGSKKRSEMEATLLPLEGGPSWRSGTFPPLPPSQSFMRTLGFLYGGRGMRSFLLNRKKKTAEGFRKIQGRDLIRIVFFEGVLYLNGLERKPKKLPRRFFNMVPLFSQLLRQHRRCPYSRLLQKTCPLVGIKDAGQAELSSFLPQHCGSHRVYLFVRECLLAVIPQELWGSEHNRLLYFARVRFFLRSGKFERLSVAELMWKIKVNNCDWLKISKTGRVPPSELSYRTQILGQFLAWLLDGFVVGLVRACFYATESMGQKNAIRFYRQEVWAKLQDLAFRSHISKGQMVELTPDQVAALPKSTIISRLRFIPKTDGMRPITRVIGADAKTRLYQSHVRDLLDMLRACVCSTPSLLGSTVWGMTDIHKVLSSIAPAQKEKPQPLYFVKMDVSGAYESLPHNKLIEVINQVLTPVLNEVFTIRRFAKIWADSHEGLKKAFIRQADFLEANMGSINMKQFLTSLQKKGKLHHSVLVEQIFSSDLEGKDALQFFTQILKGSVIQFGKKTYRQCQGVPQGSAVSSVLCCLCYGHMENVLFKDIINKKSCLMRLVDDFLLITPNLHDAQTFLKILLAGVPQYGLVVNPQKVVVNFEDYGSTDSCPGLRVLPLRCLFPWCGLLLDTHTLDIYKDYSSYADLSLRYSLTLGSCHSAGHQMKRKLMGILRLKCHALFLDLKTNSLEAIYKNIYKLLLLHALRFHVCAQSLPFGQSVAKNPAYFLLMIWDMVEYTNYLIRLSNNGLISGSTSQTGSVQYEAVELLFCLSFLLVLSKHRRLYKDLLLHLHKRKRRLEQCLGDLRLARVRQAANPRNPLDFLAIKT
Protein: Growth-regulating factor 9 (AtGRF9) (Transcription activator GRF9) (Q8S9M3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU01002}.
Interaction partners:
- GRF1-interacting factor 1
- 14-3-3-like protein GF14 epsilon
Sequence:
MKMQSPKMEQEEVEEERMRNKWPWMKAAQLMEFRMQALVYRYIEAGLRVPHHLVVPIWNSLALSSSSNYNYHSSSLLSNKGVTHIDTLETEPTRCRRTDGKKWRCSNTVLLFEKYCERHMHRGRKRSRKLVESSSEVASSSTKYDNTYGLDRYNESQSHLHGTISGSSNAQVVTIASLPSARSCENVIRPSLVISEFTNKSVSHGRKNMEMSYDDFINEKEASMCVGVVPLQGDESKPSVQKFFPEVSDKCLEAAKFSSNRKNDIIARSREWKNMNVNGGLFHGIHFSPDTVLQERGCFRLQGVETDNEPGRCRRTDGKKWRCSKDVLSGQKYCDKHMHRGMKKKHPVDTTNSHENAGFSPLTVETAVRSVVPCKDGDDQKHSVSVMGITLPRVSDEKSTSSCSTDTTITDTALRGEDDDEEYLSLFSPGV
Protein: Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) (Q62762)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity).
Subcellular location: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P78368}. Cytoplasm {ECO:0000250|UniProtKB:P78368}.
Interaction partners:
- Beta-adrenergic receptor kinase 1
- Protein smoothened
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- G protein-coupled receptor kinase 3
Sequence:
MDFDKKGGKGELEEGRRMSKTGTNRSNHGVRNSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGYVFDYEYDWAGKPLPTPIGTVHPDVPSQPPHRDKAQLHTKNQALNSTNGELNTDDPTAGHSNAPIAAPAEVEVADETKCCCFFKRRKRKSLQRHK
Protein: Apoptotic protease-activating factor 1 (APAF-1) (O88879)
Organism: Mus musculus (Mouse)
Function: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Cytochrome c, somatic
- Caspase-9
- Cytochrome c, testis-specific
- Caspase-3
- Heat shock 70 kDa protein 1B
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Diablo IAP-binding mitochondrial protein
Sequence:
MDAKARNCLLQHREALEKDIKTSYIMDHMISNGVLSVIEEEKVKSQATQYQRAAALIKMILNKDNCAYISFYNALLHEGYKDLAALLQSGLPLVSSSSGKDTDGGITSFVRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGEPGWVTIYGMAGCGKSVLAAEAVRDHSLLEGCFSGGVHWVSIGKQDKSGLLMKLQNLCMRLDQEESFSQRLPLNIEEAKDRLRVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGPKHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSLIGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGKSFCYYLHDLQVDFLTEKNRSQLQDLHRKMVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYRQAKLQAKQEGDTGRLYLEWINKKTIKNLSRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFTNKSNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVFLQAHQETVKDFRLLQDSRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVCFSPDSKTLVSAGGYLKWWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQVLE
Protein: Probable pectinesterase/pectinesterase inhibitor VGDH2 (VANGUARD1-like protein 2) (VGD1-like protein 2) [Includes: Pectinesterase inhibitor VGDH2 (Pectin methylesterase inhibitor VGDH2); Pectinesterase VGDH2 (PE VGDH2) (EC 3.1.1.11) (Pectin methylesterase 37) (AtPME37) (Pectin methylesterase VGDH2)] (Q5MFV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular location: Secreted, cell wall {ECO:0000305}.
Interaction partners:
- At5g50030
- Exopolygalacturonase clone GBGE184
- Expressed protein
- Probable pectate lyase 19
- Probable pectate lyase 6
- Probable pectate lyase 3
- At5g48140
- Putative clathrin assembly protein At1g25240
- Pectin lyase-like superfamily protein
- Protein NRT1/ PTR FAMILY 2.8
Sequence:
MAVGKVVVSVASLLLVVGVAIGVITFVNKGGGANGDSNGPINSHQKAVQTICQSTTDQGSCAKTLDPVKSDDPSKLVKAFLMATKDAITKSSNFTASTEGGMGTNMNATSKAVLDYCKRVLMYALEDLETIVEEMGEDLQQSGTKLDQLKQWLTGVFNYQTDCLDDIEEVELKKIMGEGISNSKVLTSNAIDIFHSVVTAMAQMGVKVDDMKNITMGAGAGGAARRLLEDNDSKGLPKWFSGKDRKLMAKAGRGAPAGGDDGIGEGGGGGGKIKATHVVAKDGSGQFKTISEAVMACPDKNPGRCIIHIKAGIYNEQVRIPKKKNNIFMFGDGATQTIITFDRSVKLSPGTTTSLSGTVQVESEGFMAKWIGFKNTAGPLGHQAVALRVNGDRAVIFNCRFDGYQDTLYVNNGRQFYRNIVVSGTVDFIFGKSATVIQNSLILVRKGSPGQSNYVTADGNEKGAAMKIGIVLHNCRIIPDKELEADKLTIKSYLGRPWKKFATTVIIGTEIGDLIKPEGWTEWQGEQNHKTAKYIEFNNRGPGAATTQRPPWVKVAKSAAEVETYTVANWVGPANWIQEANVPVQLGL
Protein: Sema domain-containing protein (U4PRY7)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Semaphorin-1A
- Semaphorin-2A
- Plexin-2
- Ras-like GTP-binding protein rhoA
- Sema domain-containing protein
- Ras-related protein ced-10
- Netrin receptor unc-5
- Ephrin-4
- Tyrosine protein-kinase src-1
- Rac-like GTPase
Sequence:
MPTFLQFFIIFGVAAAAAGSKNVYSIDDNLVFKNPSHDGHEVFEKMAIDPSTTRVFVGAVNSLYDLTSADLTVRRHVQTGPQDDSPLCRDARNREECRHQLSRTNSHTKALSVYDKSSKLIECSNLYQGRCRLRNLHNISEVISEAIEPRVSNDTSSSVVIFVGSGPANLSSEPVLYVGATIGSGDHDRMSVSSLFLRPQKAFEVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRVNIADDSSIQSRLVRVCTGDKNFHSYTEVPLECTQNGVEFNLVQDVYVTRAGYELAKSLDISVSDPVLYGVFWEGDKNSYRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSSNDDCRFTTLPWEGIKCGKDVNSKIGGDTPISTSATYVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKILIESKRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESCEREVPHTSRGWLDFQNSKCPRIRSVKPDQIQINTADYLNVTIENLQAPKGRRMQCLFQFSTGDAVVSDPMPFDGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPHIVAPVSKMSVATGERRNISVKVENVDATFMGDFKCEFKYGTVTHEKIAMRTSDDTITCDEMLFEPYGTSLLGSGSTPYGFNVIWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQCSNRQIPENWLNASQLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIANVPCEVVEYVPSQKIVCVTGKSPIKGSNERGVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQIGCKILERASGWLRCRMGASGEGGQFPLHIAFDGQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQERITEYAFDFDGAELYRSRIKVMPSPTFETLSEPRFVRPGEDFLTLNGNHLNLAASERDIDVKVGGEPCPLTALANKVLTCQPPVKKPRGAGKLNPEIVVTVGNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTADLPLGTPTAPFLEYKDYCARVLFPNAGKNHAVLKNLEVDTHKAEAIEAGLREFHKLLMNKTFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKFQPKILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGKMALQDIDSSSRVEGGNWKRLNTLAHYNVPNNAILTLTSKSNSLYNLVNFSSTSMKTASILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIADHASSSADTDNGFKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSSTVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDIQKPTKIEGCLSVVAQTLMDACSTQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMTPRIDDATMGANLSAESRQHNGEFHVFSALNELYKYLDQYKESIIDALESNEHAQASRLPGRLQDLLALMESDYYRATDYESSTLGLGYNSNSRLMPRDRL