wanglab/gogpt-training-data huggingface dataset:
Protein: Protein EXPORTIN 1A (AtCRM1) (AtXPO1) (Protein HEAT-INTOLERANT 2) (Q9SMV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Required for the maternal-to-embryonic transition and during gametophyte development. Involved in heat-induced oxidative stress basal resistance.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9TVM2}. Nucleus membrane {ECO:0000250|UniProtKB:Q9TVM2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9TVM2}; Nucleoplasmic side {ECO:0000250|UniProtKB:Q9TVM2}.
Interaction partners:
- GTP-binding nuclear protein Ran-1
- GTP-binding nuclear protein Ran-3
- GTP-binding nuclear protein Ran-2
- GTP-binding nuclear protein Ran-4
- Nuclear pore complex protein NUP88
- Nuclear pore complex protein NUP214
- 60S ribosomal export protein NMD3
- Protein EXPORTIN 1B
- Zinc finger CCCH domain-containing protein 16
- Snurportin-1
Sequence:
MAAEKLRDLSQPIDVGVLDATVAAFFVTGSKEERAAADQILRDLQANPDMWLQVVHILQNTNSLDTKFFALQVLEGVIKYRWNALPVEQRDGMKNYISEVIVQLSSNEASFRSERLYVNKLNVILVQIVKHDWPAKWTSFIPDLVAAAKTSETICENCMAILKLLSEEVFDFSRGEMTQQKIKELKQSLNSEFKLIHELCLYVLSASQRQDLIRATLSALHAYLSWIPLGYIFESTLLETLLKFFPVPAYRNLTIQCLTEVAALNFGDFYNVQYVKMYTIFIGQLRIILPPSTKIPEAYSSGSGEEQAFIQNLALFFTSFFKFHIRVLESTPEVVSLLLAGLEYLINISYVDDTEVFKVCLDYWNSLVLELFDAHHNSDNPAVSASLMGLQPFLPGMVDGLGSQVMQRRQLYSHPMSKLRGLMINRMAKPEEVLIVEDENGNIVRETMKDNDVLVQYKIMRETLIYLSHLDHDDTEKQMLRKLNKQLSGEEWAWNNLNTLCWAIGSISGSMAEDQENRFLVMVIRDLLNLCEITKGKDNKAVIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHPGVQDMACDTFLKIVQKCKRKFVIVQVGENEPFVSELLTGLATTVQDLEPHQIHSFYESVGNMIQAESDPQKRDEYLQRLMALPNQKWAEIIGQARHSVEFLKDQVVIRTVLNILQTNTSAATSLGTYFLSQISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGDYARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLSSPQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNFQQSEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVLQQLFCLPESGALTEPLWDATTVPYPYPDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQSKEFSAQDNKDLYAEEAAAQRERERQRMLSIPGLIAPNEIQDEMVDS
Protein: Testis-enriched HMG-box-containing protein 2, isoform B (E1JIT5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protamine A, isoform A
- GEO12017p1
- IP10875p
- GEO12122p1
- Histone-like protein 18C
- LP10995p
- Testis-enriched HMG-box-containing protein 1
- Male-specific transcript 84B, isoform B
- Sex-regulated protein janus-B
- AT22380p
Sequence:
MMSDYGARPKKPMSAFMLWMNSTGRKNIRAEHPDFSVQEVSVKGGEMWRAMADEHKIVWQESASKAMAEYKEKLEKWNAFKEHQTESFPHIYEAPLSSRFSKTNQRPTLFVYDSKDEAMAPICRTCFSKAKCFH
Protein: DNA damage repair protein, putative (Q4FKQ0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA polymerase eta
- DNA polymerase
- Proliferating cell nuclear antigen
- Polyubiquitin, putative
- Ubiquitin-like protein, putative
- Ubiquitin/ribosomal protein S27a, putative
- Ubiquitin-ribosomal protein eL40 fusion protein
- Replication factor C, subunit 3, putative
- Replication factor C, subunit 2, putative
- Replication factor C, subunit 4, putative
Sequence:
METNGPKRSRVRDQLNSLKHFQQHSRLHFIGQWKTKAHDLFKEWFAENPAWNHGVLDRQAIFAHLDMDAFFCSVVLAREENAHLRDKPVCVAAGRGNSDISSCNYVARSFGVRAGMYVNAARVLCPDLRVLSYDLERSGEVAMCLYRMIFELCPAHLTMSVEVYSVDEVMIAFDTDSYEAVEDYCNEVRRELEAATKCTVSCGIGPNVMLARIATQSAKPDGTFIVRPEDVTAIVSQLPFSEIHGAGSSTIAKLVPLLGDYLGDMEGVGEENILCQHVQKLTKQQLQRVLGQKTGENFYNLCRGNDVRLVTRTGDEENQRLMGKRTRASIGCSMNYAVRPKTVEDVWSIARQLLDVVCAKMGRGPYCCSGLRVTILERHPLHPKETLKYMGRGKCLEFHIPVNFSSVLKSCDMEIMLACVERALGPLLVLGRTMRDEERVEELGLQESTKSGIIWTVGVDTITDIVIEDIRGMSIQATAVRLEHDGKDTPKHTTGVQLSLADAFSKRASNQKGSLVNGGKPAKRPPSSSGDSIDFLALDDLMNHNVDDSFVSEWKKLAVQAGKQVDYTTLKALIRIAALRCAESPKPSGEMKELFRTLVSFAQGLLPHPVAFT
Protein: Protein transport protein sec73 (O13817)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in protein transport.
Interaction partners:
- Translocation protein sec62
- PH and SEC7 domain-containing protein C11E3.11c
- ADP-ribosylation factor 1
- Protein transport protein sec61 subunit alpha
- Translocation protein sec63
Sequence:
MTFRIPSSQESSNKSEKDTTVNSPNASSFSSFFKKSSQTYLSKRSEKLNEHNSKLKSSGSFTSNSQTDLSNSPSSKKKNIFYPIARAKHSFYFNHNWSSDLQQANSPVASYSSQSVSNDSNFPKDVTSPISTDLSGSNPSLKSPSSINSAKLRASRSFFRFPKWSRKSWNPDVNSTTSSPSEVGSLDKAGGPLNQQNENLSAESDNTILQNGTRKSSVKMSDLGKRIASLPVVKRPPIQFSISSDYIKPVDKSDQTSNVPSPSSSVGSLRLYRSPSIPNDVEQPQPQSSRSRPRSSTIPTQRTLERLRENRSSIFSFRTLRRDDDECVAQTIENSALFSDIKPNPTKFLSSVPELTADDTAESYLSKLRETVPYSRMIPVLAEKDHVTLNKALHLCMSGMEFENRPLDFCLRLFLLKSHLPKETQQIDRVINAFSKRYFECNPGMFSSQDQCYILVFSLMMLHTDVFNSNNKHKMTKQEFINLCDIDELAPEIMEYYYDNITFTPFVNLDDELLLIEKEKNEKYNFTSRKRLGLSPYTFTLENQLNISRPEISLSYDGKFISPGIKDIASLLNVRKLISSPAIIQLVSKRSHPMAFSNHFIGLPDNADPGLVDFSISMLGILPRCEKKRRSVGHNSYKEHLVLLTASRILFFRNLVWAKDLMAQKKAYERRYKNFTTTSSSFDTLQGIDTEAMEYEFPKIPPLVFTPPLEEFSPDTSYSLVNAFAYCDRDKKNVRNCSFTVIFRDGSEETLCAPTEESMIEWVAKINYISTLRTAGLRMPVSDSYHPKRDFSCYPKYMEEELAAIEAQMKQDMEIARARTIKTRIDQLETSITEFNKKLMVLQRNAKNLSTCAPLQPKTRVVILQALKKVDAKAQSLYLEIRKMESQLQVLRFESDLDKCISLESSNDIDDRPSSTSPSTLKNPSINSINRQTHDVEKESSDRDVPHLLDPDNNFNLKGNPENPSSTFFTPEILSPKVYSDNVKDEPVEDIFGFEDTSESSPGKPSQLRLQIEAFDDELADTASLGSVTTCLDQWQTFSDDTDSGFALNLYSSEDFRTDPYKEHDEFSMNSLSKWHSATSDN
Protein: Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2) (Q9QX72)
Organism: Rattus norvegicus (Rat)
Function: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:10637234}. Nucleus {ECO:0000305|PubMed:10637234}.
Interaction partners:
- Similar to MJ0495-like protein SelB
- Large ribosomal subunit protein eL30
- tRNA selenocysteine 1-associated protein 1
- Phosphoseryl-tRNA kinase
- Eukaryotic initiation factor 4A-III
- Thioredoxin reductase-like selenoprotein T
- O-phosphoseryl-tRNA
- Selenoprotein N
- Thioredoxin reductase 1, cytoplasmic
- Selenoprotein K
Sequence:
MASERPREPEGEDSIKLSADVKPFVPKFAGLNVAWSESSEACVFPGCAATYYPFVQESPAAEQKMYPEDMAFGAPAFPAQYVSSEIALHPFAYPTYALESTQSVCSVPTLQYDYSQAQCHPGFRPAKPRNEHACPPQEAKCVFKKKSSDERRAWEEQKSSNRRADGAVPCEARPARGSCHLKSDGYHKRPDRKSRILTKSASTSKPEFEFSRLDFPELQSPKNSNLPETQKQPRWGPLGPAASNMSLLGEAGKPVADMVEGKMVKTDHTDGAVTNNAATSSPSCTRELSWTPMGYIVRQTVSSDSAAATETVNSIINLKKTTSSADAKNVSVTSEALSSDPSFSREKRVHPGPKAKASQGSELEQNESSKKNKKKKEKSKSSYEVLPVQEPPRIEDAEEFPNLSVASERRHRGESPKLQSKQQAQNDFKTGGKKSQVPVQLDLGGMLAALEKQQHAPHAKPSSRPVVFSVGAVPVLSKDASSGERGRRSSQVKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERMQQRLQESAVSPTVASDDSQDVESGVTNQIPSPDNPTGPEKTEEPMSSTPVVEGESEEPAGTEFQRDPEACQPAPDSATFPKIHSRRFRDYCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALGRSLNKAVPVSIVGIFSYDGAQDQFHKMVELTMAARQAYKTMLETMRQEQAGEPGPQTPPSPPMQDPIQSTDEGTLASTGEEPHYIEIWRKHLEAYSQHALELEDSLEASTSQMMNLNL
Protein: Cannabinoid receptor 2 (Q20HN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell projection, neuron projection {ECO:0000256|ARBA:ARBA00004487}.
Interaction partners:
Sequence:
MENKLEQDQEATTVLYSNLSTQNISTTDKSLCYSLQCYMVLTTQEQKAISSICFLAGPVTFLANILVLLTIASSTALRRRPSYLFISSLALADMFASCFFTISFLDFHLLSQRDDANLYLFKLGGVTMAFTGSVGSLLLTALDRYLCIYQASNYKLLLTRTRAKLAILLLWCVTIILSFLPLMGWRCKTWLDRPCSRLFPYVDRHYLASWTGLQLVMLFLIIVAYPLILWKANRHEANMGGPKLGRQSVKGQARMRMDIQLAHTFSLILLILAICWLPVLSFMLVDVRVTLTNKQQRMFAFCSTLCLVNSCVNPLLYALRCRELRGEMLALIECCKACREHALGHTHGQITDSSSGKKSKNPAVSGSNPEIVSRSADRQQNSI
Protein: ABC transporter B family member 26, chloroplastic (ABC transporter ABCB.26) (AtABCB26) (Antigen peptide transporter-like 1) (Transporter associated with antigen processing-like protein 1) (AtTAP1) (Q8RY46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:18431481}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:18431481}.
Interaction partners:
- PyrD
- Uncharacterized protein
- ABC transporter B family member 24, mitochondrial
- ABC transporter B family member 23, mitochondrial
Sequence:
MAQQVLGCTSRPIRVSLHRCSVITTSDTIRRKNLRFVRNPRLSFSLQSSTRNYRLPSINCSTVNGAVAETAEYYEGEGDNVSLAEKIRQCIDFLRTILPGGSWWSFSDEVDGRFIAKPVTVWRALSRMWELVAEDRWVIFAAFSTLIVAALSEITIPHFLTASIFSAQSGDIAVFHRNVKLLVTLCVTSGICSGIRGCFFGIANMILVKRMRETLYSTLLFQDISFFDSQTVGDLTSRLGSDCQQVSRVIGNDLNMIFRNVLQGTGALIYLLILSWPLGLCTLVICCILAAVMFVYGMYQKKTAKLIQEITASANEVAQETYSLMRTVRVYGTEKQEFKRYNHWLQRLADISLRQSAAYGIWNWSFNTLYHATQIIAVLVGGLSILAGQITAEQLTKFLLYSEWLIYATWWVGDNLSSLMQSVGASEKVFQMMDLKPSDQFISKGTRLQRLTGHIEFVDVSFSYPSRDEVAVVQNVNISVHPGEVVAIVGLSGSGKSTLVNLLLQLYEPTSGQILLDGVPLKELDVKWLRQRIGYVGQEPKLFRTDISSNIKYGCDRNISQEDIISAAKQAYAHDFITALPNGYNTIVDDDLLSGGQKQRIAIARAILRDPRILILDEATSALDAESEHNVKGVLRSIGNDSATKRSVIVIAHRLSTIQAADRIVAMDSGRVVEMGSHKELLSKDGLYARLTKRQNDAVL
Protein: ARTA (Q5B4M9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- CD42_CHICK Cell division control protein 42 homolog
- Serine/threonine-protein kinase ste20
- 14-3-3 protein
- M-phase inducer phosphatase
- Transcription factor
- Response regulatory domain-containing protein
- Tuberin
- Ran-specific GTPase-activating protein 1, putative
- Ran specific GTPase activating protein An-RanGAP
Sequence:
MGHEDAVYLAKLAEQAERYEEMVENMKVVAASDVELTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNESQVALIKEYRQKIEGELAKICQDILDVLDQHLIKSAQSGESKVFYHKMKGDYHRYLAEFAVGDNRKAAADASLEAYKSATEVAQTDLAPTHPIRLGLALNFSVFYYEILNSPDQACHLAKLAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEPAAENAPAEKKEEAPAAEGEEKPAE
Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (Q9W326)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Segment polarity protein dishevelled
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin
- GH17761p
- Mothers against decapentaplegic homolog
- 26S proteasome non-ATPase regulatory subunit 4
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MEPPAAPVPLQPLAASSACLADRSPVDPIAVRLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE
Protein: Killer cell lectin-like receptor subfamily G member 1 (Mast cell function-associated antigen 2F1) (O88713)
Organism: Mus musculus (Mouse)
Function: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}.
Interaction partners:
- Cadherin-1
- Natural killer cells antigen CD94
- Cadherin-2
- Interleukin-7 receptor subunit alpha
- CD27 antigen
- Interferon gamma
- T-box transcription factor TBX21
- CD160 antigen
- L-selectin
- Granzyme B
Sequence:
MADSSIYSTLELPEAPQVQDESRWKLKAVLHRPHLSRFAMVALGLLTVILMSLLMYQRILCCGSKDSTCSHCPSCPILWTRNGSHCYYFSMEKKDWNSSLKFCADKGSHLLTFPDNQGVKLFGEYLGQDFYWIGLRNIDGWRWEGGPALSLRILTNSLIQRCGAIHRNGLQASSCEVALQWICKKVLY
Protein: Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Immature colon carcinoma transcript 1 protein homolog) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29) (Q8R035)
Organism: Mus musculus (Mouse)
Function: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q14197}.
Interaction partners:
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein bL32m
Sequence:
MATAWGLRWGLSRTGTLLLAPPARCARRALHRQVDGTTFQSIYSLDKLYPESKGADTAWKVPEHAKQASSYIPLDRLSISYCRSSGPGGQNVNKVNSKAEVRFHLASADWIEEPVRQKIALTHKNKINKAGELVLTSESSRYQFRNLAECLQKIRDMIAEASQVPKEPSKEDARLQRLRIEKMNRERLRQKRLNSALKTSRRMTMD
Protein: Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) (P84039)
Organism: Rattus norvegicus (Rat)
Function: Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (By similarity). May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity in vitro.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MIPEFLVVSCTLAALCHSVPLSLQTEQQKVLVVSFDGFRWDYLYKVPTPHFHYVMKNGVHVKQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPVLNKSFSLEHMNIYDSKFWEEATPLWITNQRAGHASGAAMWPGTDVKIHESYPTHYLPYNESVSFEDRVAKIIEWFTAKDPINLGFLYWEEPDDTGHDVGPDSPLMGPVISDIDHKLGYLIKMLKKAKLWNNINLIVTSDHGMTQCSKERVIELDQYLDKEHYTLIDHSPVAAILPKEGKFNEVYDALANAHPNLTVYKKEEIPERWHYKHSDRVQPIVAVADEGWYILQNKSDEFLLGNHGYDNALAEMHPIFLAHGPAFRKNFTKEAMNSTDLYSLVCHLLNVTALPHNGSFRNVQDLLSSAAPKAIPYTQSTTLPLGSAKPGEYEQEESYPYYIGISLGSLIAIVFFVVLIKHLIRSQMHTLQYMQVEVAQPLLQA
Protein: Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Q60972)
Organism: Mus musculus (Mouse)
Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q09028}. Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000250|UniProtKB:Q09028}.
Interaction partners:
- DNA helicase
- Histone-lysine N-methyltransferase EZH1
- Protein lin-52 homolog
- Chromodomain-helicase-DNA-binding protein 4
- Protein Jumonji
- Histone deacetylase 1
- Polycomb protein EED
- Polycomb protein Suz12
- Protein lin-9 homolog
- Histone deacetylase 2
Sequence:
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Protein: Profilin-3 (Q21193)
Organism: Caenorhabditis elegans
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Actin
- Actin-depolymerizing factor 2, isoform c
- Gelsolin-like protein 1
- Ras-like GTP-binding protein rhoA
- WAPL domain-containing protein
- Actin-related protein 2
- FH2 domain-containing protein
- Actin
- Alpha-actinin, sarcomeric
- Twinfilin
Sequence:
MSWSDIINNNLIGSGNVSKAAILGFDGAVWAKSDNFNISVEEAVAAGKAFTSLDALLGTGLRLEGQKFLVLNADNDRIIGKQGGSGFFIYKTIQAVIISIYEKGLQPEMCSKTTGALADYFRSIKY
Protein: Malic enzyme (A0A060XDT5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase, cytoplasmic
- Uncharacterized protein
- malate synthase
- Probable D-lactate dehydrogenase, mitochondrial
- Pyruvate kinase
- Pyruvate kinase C-terminal domain-containing protein
- Pyruvate kinase
- Pyruvate kinase
Sequence:
MAFTLQERLQLGIHGLLPPVFLSQDVQVLRIMRSYEGRNPLDKYILLMTLQDRNEKLFYRLLTSDVEEFMPIVYTPTVGLACQQYGLAFRRPRGLFITIHDKGHIATMLNSWPEENIKAIVVTDGERILGLGDLGSYGMGIPVGKLALYTACGGVPPQQCLPVLLDVGTDNQALLEDPLYIGLKHKRVRGKEYDDLIDEFMQAVTDKYGMNCLIQFEDFANSNAFRLLNKYRNHYCTFNDDIQGTASVAVAGVLAALKITKNKLSDHTFVFQGAGEAALGIAHLLIMAMAKEGVSATDAAKKIWMVDSRGLIVKGRGNLNHEKEEFAHDHAHIKTLEEVVHTIKPTAIIGVAAIAGAFNENIIKDMASFNERPIIFALSNPTSKAECTAEHCYQLTEGRGIFASGSPFSKVTLADGRSFIPGQGNNAYVFPGVALGVIACGVRQISDDIFLTTAEAIADMVTEEHLAEGRLYPPLNSIREVSFKIAVKVVDYAYRHNIASLYPEPKDKEAFVLSHVYSPDYDSFIQDTYNWPKDAMKVQNM
Protein: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase (HOPDA) (EC 3.7.1.13) (Q9AQM4)
Organism: Metapseudomonas resinovorans (Pseudomonas resinovorans)
Function: Involved in the degradation of carbazole, a toxic N-heterocyclic aromatic compound containing dibenzopyrrole system. Catalyzes the hydrolytic cleavage of a carbon-carbon bond of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid (HOPDA) to yield anthranilate. CarC is specific for 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (6-phenyl-HODA), and has little activity toward 2-hydroxy-6-oxohepta-2,4-dienoic acid and 2-hydroxymuconic semialdehyde. The effect of the presence of an amino group or hydroxyl group at the 2'-position of phenyl moiety of 6-phenyl-HODA on the enzyme activity is found to be small.
Interaction partners:
Sequence:
MLNKAEQISEKSESAYVERFVNAGGVETRYLEAGKGQPVILIHGGGAGAESEGNWRNVIPILARHYRVIAMDMLGFGKTAKPDIEYTQDRRIRHLHDFIKAMNFDGKVSIVGNSMGGATGLGVSVLHSELVNALVLMGSAGLVVEIHEDLRPIINYDFTREGMVHLVKALTNDGFKIDDAMINSRYTYATDEATRKAYVATMQWIREQGGLFYDPEFIRKVPVPTLVVHGKDDKVVPVETAYKFLDLIDDSWGYIIPHCGHWAMIEHPEDFANATLSFLSRRADITRAAA
Protein: Protein male abnormal 3 (O18214)
Organism: Caenorhabditis elegans
Function: Transcription factor which binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- DM domain-containing protein mab-23
- Sex-determining transformer protein 1
- NAB transcription cofactor mab-10
- Homeobox protein ceh-30
- Sex-determining protein fem-1
Sequence:
MLTEDPVSEICEAKAVDELAEQEKNYYCQRCLNHGELKPRKGHKPDCRYLKCPCRECTMVEQRRQLNNLLSKKKIHCTPATQTRDGKRVRDPHCARCSAHGVLVPLRGHKRTMCQFVTCECTLCTLVEHRRNLMAAQIKLRRSQQKSRDGKEPKRNSRRKSKDMDMEMMVVTATDGQKIIGTSASPSPSSTTDTMSPSLSMSPPCSPSPLLAQYTLTLAAPIPIYPPIPMNQQLISLQQQQFLMSIIQNMAPSIGQQAPLLPGISAGSVSSAAILNEFWSMYLKNYGLQA
Protein: STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) (Q9UHE8)
Organism: Homo sapiens (Human)
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q9CWR7}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:32409586}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Metalloreductase STEAP2
- Prostate stem cell antigen
- Natural resistance-associated macrophage protein 2
Sequence:
MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL
Protein: Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (Q8SXM8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAASGELSKNELKRRLKAEQKAKEKAEKAAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSPATDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMASAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITEQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPEDANRTAAETAPTAQQ
Protein: Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2) (Q8ICR0)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase. During male gametogenesis in the mosquito gut, required for male exflagellation, possibly by regulating male gamete exit from the host erythrocytes. Not required for asexual blood stage proliferation.
Interaction partners:
- Calmodulin, putative
Sequence:
MGNHLSVNKLKRKKKKKSFLNIYGKNTNENTSKQSNDYKYDINTSCISREGTTTLERKNLILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIALTIIAKHLCDVEINNLRNIFIALDVDNSGTLSSQEILDGLKKIGYQKIPPDIHQVLRDIDSNASGQIHYTDFLAATIDKQTYLKKEVCLIPFKFFDIDGNGKISVEELKRIFGRDDIENPLIDKAIDSLLQEVDLNGDGEIDFHEFMLMMSKKK