wanglab/gogpt-training-data huggingface dataset:
Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) (A0A3B3IT25)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEFDVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVSEVWAIEDVLSLNSETL
Protein: Protein Wnt-4a (P47793)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled class receptor 2
- Frizzled-3
- Frizzled-4
- Low density lipoprotein receptor-related protein 5
- Frizzled-5
- Frizzled class receptor 6
- Frizzled class receptor 8b
- Secreted frizzled-related protein 1
- Frizzled class receptor 1
- Frizzled class receptor 10
Sequence:
MSSEYLIRSLLMLFLALFSANASNWLYLAKLSSVGSISDEETCEKLRGLIQRQVQICKRNVEVMDAVRRGAQLAIDECQYQFRNRRWNCSTLESVPVFGKVVTQGTREAAFVYAISAASVAFAVTRACSSGELDKCGCDRNVHGVSPEGFQWSGCSDNIAYGVAFSQSFVDIRERSKGQSSNRALMNLHNNEAGRKAILNHMRVECKCHGVSGSCEVKTCWKAMPPFRKVGNVIKEKFDGATEVELRKVGTTKVLVPRNSQFKPHTDEDLVYLDPSPDFCEHDPRTPGIMGTAGRFCNKTSKAIDGCELMCCGRGFHTEEVEVVDRCSCKFHWCCYVKCKQCRKMVEMHTCR
Protein: Transcription elongation factor S-II (DNA strand transfer protein alpha) (STP-alpha) (DNA strand transferase 1) (Pyrimidine pathway regulatory protein 2) (P07273)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular location: Nucleus.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Transcription elongation factor SPT4
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB7
Sequence:
MDSKEVLVHVKNLEKNKSNDAAVLEILHVLDKEFVPTEKLLRETKVGVEVNKFKKSTNVEISKLVKKMISSWKDAINKNKRSRQAQQHHQDHAPGNAEDKTTVGESVNGVQQPASSQSDAMKQDKYVSTKPRNSKNDGVDTAIYHHKLRDQVLKALYDVLAKESEHPPQSILHTAKAIESEMNKVNNCDTNEAAYKARYRIIYSNVISKNNPDLKHKIANGDITPEFLATCDAKDLAPAPLKQKIEEIAKQNLYNAQGATIERSVTDRFTCGKCKEKKVSYYQLQTRSADEPLTTFCTCEACGNRWKFS
Protein: Spindle pole body component alp16 (Altered polarity protein 16) (P87244)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:12134075}. Note=And the microtubule organizing center (MTOC).
Interaction partners:
- Gamma-tubulin complex subunit mod21
- Gamma-tubulin complex component gfh1
- Spindle pole body component alp4
- Spindle pole body component alp6
- Mitotic-spindle organizing protein 1
- Tubulin gamma chain
- Gamma tubulin complex adapter mto1
- Gamma tubulin complex adapter mto2
- DnaJ-related protein rsp1
- Myosin type-2 heavy chain 2
Sequence:
MDGIMKNDLLWFGNHVFDLTPNSFDSDFVEQLSKFEGKEGLKRKLFDSSEYFQNFSFQVNDDLLGKDVILDISNQQLTPAVPGCETSSNSKLISASKEITSERKRAKSSVSPSYLTDSSPSDLSVENKVLLTCPSWDGENFKNLEARSPFISEAPSRVYDYFLHNQDWSPKPLFSALQVYPLATIFNCVAGLPQGFESTVFPWNKTSSTFELDPTISVSGMSDECFASIVQKFSAIGGLIKKALNEFSLYKTNISFYLSNFIVNGVLQYRKEFQRWLRLYEFRRFGLIGLSNFVNSFSSFFELISHFLIKSAQNLKGDSLLDFLFDYARSCQNTISYPIALQCLIYCSNPYFKRLELALKVSCAYGHIDSSLFLSLPRFFPSELCVSIEQCIQFLSLIREQKEIFNKNNKEFINPLNIRFAYSFNDINQACVIEERCNFSSLSFGNLEQTSVNNDSEEFETLLAKMNMTPDFNDNLLQLKFTDDVRNVCPLNLNVCCCIAEPIQSFILSFLRSTYKVLKNDFQVFDLLNFFHSTFLFQNYEFSDNVISLLKSRRLDKSDRNELAEDLNSDDRYNFISRLKKFIFMEKEKNGLSRSLSKSITFTLDSASVSEFEDVYPDLQFQCQVIGALRILFTDNSLNYYSKTFSYVLHLFQAQSDFESSVELKDRSIVTKTTIMSWSKYQGTKESLFQFLSIYIPECMLPFTKLLKSIYSPDCPTNIQNSAIKNAASVHEQCTKAIYQKVKELFDTMKLWESSIKVS
Protein: Endo-1,4-beta-xylanase A (Xylanase A) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase A) (Endo-1,4-beta-xylanase G2) (Xylanase G2) (Q9HFA4)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular location: Secreted {ECO:0000269|PubMed:16672490}.
Interaction partners:
- Endo-1,4-beta-xylanase F1
- Endo-1,4-beta-xylanase F3
- Xylanolytic transcriptional activator xlnR
- Exo-1,4-beta-xylosidase xlnD
- Probable 1,4-beta-D-glucan cellobiohydrolase A
- DNA-binding protein creA
- Probable catabolite repression protein creC
- Probable HECT-type ubiquitin ligase-interacting protein creD
- D-xylulose reductase A
- Probable alpha-glucuronidase A
Sequence:
MVSFSSILLACSAAIGALATPIEPLADHPNEAFNETAFNDLVGRSTPSSTGYNNGYYYSFWTDGGGDVTYTNGNGGSYSVQWSNVGNFVGGKGWNPGSSRAITYSGSFNPSGNGYLAVYGWTTDPLIEYYIVESYGTYNPGSGGTYKGQVTSDGGTYNIYTSVRTNAPSIIGTATFTQFWSVRTSKRVGGTVTTGNHFNAWAKYGLTLGTHNYQIVATEGYQSSGSSAITVY
Protein: Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1) (Q9QYC3)
Organism: Mus musculus (Mouse)
Function: Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MKTKNRPPRRRTPMQDTEATPGEQTPDRPQSGSGGSELTKGLRSRTARASGGRGEVSRRRQGSGGRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAMLGVTEDQPQGHLQRYSTQIHSFREGS
Protein: Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) (O14253)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the CBC complex, which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P34160}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nuclear cap-binding protein subunit 2
- Eukaryotic translation initiation factor 4 gamma
- NURS complex subunit pir2
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein-associated protein B
- U4/U6.U5 tri-snRNP-associated protein snu66
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein Sm D1
- Pre-mRNA-processing factor 17
- Nonsense-mediated mRNA decay protein 3
Sequence:
MSSYRGSTRPRKRTREGENYGFRPHRGNSQELLAARIKKDITFLADPRGNSVAADDINYVAMSLSREANDPETISTILDCIQTTAFIIPVKIPHLATLIIRASLRVPLILEKAAAYFCLQYFTNLNSFLYYEAKVDLRMLICMSFALQPGTLKPLFSLLADAISKETKPSVWGDNFLRIILINLPYFIAANNDLGKKDFANEILDQCEIYVRHRKSSITLSNPLSIHDNLSEEELDLLYKQLILSRENDFTFPYISQPWKFFESDFVHIVPVSPSIPEWTFQPTPQQNELPSFKRFFELFNNFEIRTTPDASDVAASIFRDISVDVINHLEFNRVEAAQVLTDLDVYFTYKTFALRGTPVNELPNLDPSESRWKAEDIIVEAVLGELLGSQNTTYKPVYYHSLLIECCRIAPKILAPTFGRVIRLMYTMSSDLPLQTLDRFIDWFSHHLSNFNFHWKWNEWIPDVELDDLHPKKVFMRETITRELILSYYTRISDSLPEELRCLLGEQPSGPNFVYENETHPLYQQSSQIIEALRLHKPLEELDIILQSEEIQNSETSAVRLVMSCAYSLGSRSFSHALNVFEKHLNTLKHFSRKSLDSEIEVVDELFSFWKLQPFNAVMWLDKMLNYSIISITSIIEWLIKQDVTIWSRSYTWSLVNTTFNKLAARLRRSVSNKEDSSLINEANEEKEIVTNLLLSALRALISENAENIWVSHWLNLMLKYVESNFLSVKKDTIEEANEPVQENTSEEQEDTKMQPVDAVDEQPSENNQTAADATNEEK
Protein: PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) (Q9EP80)
Organism: Rattus norvegicus (Rat)
Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23889934}. Membrane {ECO:0000269|PubMed:23889934}; Peripheral membrane protein {ECO:0000269|PubMed:23889934}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Postsynaptic density {ECO:0000269|PubMed:23889934}. Synapse, synaptosome {ECO:0000269|PubMed:23889934}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23889934}. Note=Also membrane-associated, present at excitatory synapses.
Interaction partners:
- Glutamate receptor 2
- Glutamate receptor 3
- Protein kinase C alpha type
- Tetraspanin.
- Islet cell autoantigen 1
- Glutamate receptor-interacting protein 1
- Disks large homolog 4
- Glutamate receptor 1
- Glutamate receptor 4
- Glutamate receptor-interacting protein 2
Sequence:
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRFVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGPNQGGFTDGEDEEEEEEDGAAREVSKDARGATGPTDKGGSWCDS
Protein: Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ (EC 2.3.1.-) (P37750)
Organism: Escherichia coli (strain K12)
Function: Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen.
Interaction partners:
- Putative glycosyltransferase WbbK
- Beta-1,6-galactofuranosyltransferase WbbI
- Putative O-antigen polymerase
- UDP-galactopyranose mutase
- Putative O-antigen transporter
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Glucose-1-phosphate thymidylyltransferase 1
- dTDP-glucose 4,6-dehydratase 1
- dTDP-4-dehydrorhamnose reductase
- dTDP-4-amino-4,6-dideoxygalactose transaminase
Sequence:
MILKLAKRYGLCGFIRLVRDVLLTRVFYRNCRIIRFPCYIRNDGSINFGENFTSGVGLRLDAFGRGVIFFSDNVQVNDYVHIASIESVTIGRDTLIASKVFITDHNHGSFKHSDPMSSPNIPPDMRTLESSAVVIGQRVWLGENVTVLPGTIIGNGVVVGANSVVRGSIPENTVIAGVPAKIIKKYNHETKLWEKA
Protein: Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (p28) (Q8K3I6)
Organism: Mus musculus (Mouse)
Function: Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.
Subcellular location: Secreted {ECO:0000269|PubMed:12121660}. Note=Poorly secreted without coexpression of EBI3.
Interaction partners:
- Interleukin-27 subunit beta
- Interleukin-27 receptor subunit alpha
- Cytokine receptor-like factor 1
- Interleukin-6 receptor subunit beta
- Interleukin-12 subunit alpha
- Signal transducer and activator of transcription 1
- Interleukin-12 subunit beta
- Signal transducer and activator of transcription 3
Sequence:
MGQVTGDLGWRLSLLLLPLLLVQAGSWGFPTDPLSLQELRREFTVSLYLARKLLSEVQGYVHSFAESRLPGVNLDLLPLGYHLPNVSLTFQAWHHLSDSERLCFLATTLRPFPAMLGGLGTQGTWTSSEREQLWAMRLDLRDLHRHLRFQVLAAGFKCSKEEEDKEEEEEEEEEEKKLPLGALGGPNQVSSQVSWPQLLYTYQLLHSLELVLSRAVRDLLLLSLPRRPGSAWDS
Protein: Orf258 protein (Q8HCR0)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MKPLGRMTDDPVQLVADLMLQNTNQWDVEKVQRIFFPLDAAAILNMPRPRTEQDDFWAWAWDRTGIFTVRSAYRELIQRCGLSEPATGSSTGDEATWKALWRLRIMPKIRVFWWRVVKNLLPCAAELRRSHMKEISNCPLCGNDNETKFHALVECEHAKLFWSAAQDLFDLKMPRLNPATWSRDVLDADIMSKREAAIAVSVMWTIWGSRNSYNHGDVKYQPLSSVELVDELINLWRFQLRRTHRLWFRSGLDLLWDG
Protein: PTB domain-containing adapter protein ced-6 (Cell death protein 6 homolog) (Q7JUY7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth.
Subcellular location: Cytoplasm.
Interaction partners:
- Protein draper
- Ced-12
- Adapter molecule Crk
- LD08195p
- Tyrosine-protein kinase Shark
Sequence:
MPYQPANSGGTSGGSKAAAKMAQLKFWNKQNSSKQQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDLAYRKYMDSTEKTNLSKAQQQINHLQQTVNVYKERLREVSAKLPKAELDALLFNLGIKDILEAPTTEPQNGIEVASEALSNGKLDDDKLLIDTNSTTASTHSASPSSFLPIVPPRNNLSSQISIGGKSNSQKMDELLLNSDSDSDFDPRADETQEIGGTGRSAISNMFGFEPANSFGQHLFSNNNDHKLQNNNSSLLITSNNNSINSSGFSSELNITPPLLAPPPKIAAPRRLNSVTTGNGLNGNTDLFGSDPFELNNGPNIFKQNQLNLDDFSLESLDPLRK
Protein: CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166) (Q61490)
Organism: Mus musculus (Mouse)
Function: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15345243, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:9209500}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:15345243}. Cell projection, dendrite {ECO:0000269|PubMed:15345243}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse. {ECO:0000250|UniProtKB:Q13740}.
Interaction partners:
- T-cell differentiation antigen CD6
- Galectin-8
- Thy-1 membrane glycoprotein
- 5'-nucleotidase
- Endoglin
- CD44 antigen
- Integrin beta-1
- Signal transducer CD24
- Hematopoietic progenitor cell antigen CD34
- Neural cell adhesion molecule L1
Sequence:
MASKVSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSIANAKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNKAPFLETDQLKKLGDCISRDSYPDGNITWYRNGKVLQPVEGEVAILFKKEIDPGTQLYTVTSSLEYKTTRSDIQMPFTCSVTYYGPSGQKTIYSEQEIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNPPPEEFMFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKRNMAASTTITVHYLDLSLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIHWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
Protein: Protein N-terminal amidase (NT-amidase) (EC 3.5.1.-) (P40354)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Deamidates N-terminal Asn and Gln. Component of a targeting complex in the N-end rule pathway.
Interaction partners:
- Arginyl-tRNA--protein transferase 1
Sequence:
MLIDAIHGAKMSTKLLVSLKVLVIQLNPQIGQVDQTIKRTWSILDKVTKSATYVKPDIILFPEFALTGYSFHARKDILPYVTKKDEGPSFELAKSISEKFQCYTIIGYPEDDDEQKLYNSALVVNPQGEQIFNYRKTFLYDTEMNWDCEENPEGFQTFPMDFSKCAKLSNEDSYNRDVTLKASIGICMDLSPYKFMAPFNHFEFSSFCVDNNVELILCPMAWLNSTSITDKQTLHNNSLLEAAKNKIAFALKEQGLPLAGSQGIYQLKIGDSQRTPRVPSDDSTSEYKDMDEPDMSNVNYWILRFFPFLYFKSRINWFKNSSLIESILGKTRMPLDHEYYKDGKHKEDTIDLLDSEEVIKDTVLEKTFLGTSLGQPWKFQGKNAILVLANRCGTEDGTTIFAGSSGIYKFNGKKPKGSQDDDESSLDSLNESVELLGNLGKGLEGAILREVQFEVFR
Protein: Regulator of microtubule dynamics protein 2 (RMD-2) (hRMD-2) (Protein FAM82A1) (Q96LZ7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.
Interaction partners:
- Regulator of microtubule dynamics protein 3
- Vesicle-associated membrane protein-associated protein B/C
Sequence:
MPYSTNKELILGIMVGTAGISLLLLWYHKVRKPGIAMKLPEFLSLGNTFNSITLQDEIHDDQGTTVIFQERQLQILEKLNELLTNMEELKEEIRFLKEAIPKLEEYIQDELGGKITVHKISPQHRARKRRLPTIQSSATSNSSEEAESEGGYITANTDTEEQSFPVPKAFNTRVEELNLDVLLQKVDHLRMSESGKSESFELLRDHKEKFRDEIEFMWRFARAYGDMYELSTNTQEKKHYANIGKTLSERAINRAPMNGHCHLWYAVLCGYVSEFEGLQNKINYGHLFKEHLDIAIKLLPEEPFLYYLKGRYCYTVSKLSWIEKKMAATLFGKIPSSTVQEALHNFLKAEELCPGYSNPNYMYLAKCYTDLEENQNALKFCNLALLLPTVTKEDKEAQKEMQKIMTSLKR
Protein: Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (P97838)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9115257}; Peripheral membrane protein {ECO:0000269|PubMed:9115257}. Postsynaptic density {ECO:0000269|PubMed:9115257}. Synapse {ECO:0000269|PubMed:9115257}. Note=Postsynaptic density of neuronal cells.
Interaction partners:
- SH3 and multiple ankyrin repeat domains protein 3
- Disks large homolog 4
- SH3 and multiple ankyrin repeat domains protein 1
- Disks large homolog 3
- SLIT and NTRK-like family, member 5
- SH3 and multiple ankyrin repeat domains protein 2
- Disks large homolog 2
- Disks large-associated protein 2
- Neuroligin-3
- Neuroligin-1
Sequence:
MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTEPRFCAPRAGLGHLSPEGPLSLSEGPSSVGPEGGPGGVGAGGSSSTFPRMYPGQGPFDTCEDCVGHPQGKGATRLLPTFLDQFEKQLPVQQDGFHTLPYQRGPAGPGPGPGSGAAPEARSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKAEGRSSSGGDSYSGPGSGGPPTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQTKATGWWSSDDNLDSDSGFLGGRPPGEPGGPFCLDAPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMMVSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRSGSYIKAMGDEESGDSDGSPKTSPKALARRFASRRSSSVDTARINCCVPPRIHPRSSIPGYSRSLTTGQLSEEFNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAGCSQDDDCLPLLAAPASVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHESFTAAEGPARRCSSADGLDGPTMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLARQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFGRPFQRQASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPPPVPAPGPGSGRRDSWMERGSRSLPDSGRTSPCPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSLDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL