wanglab/gogpt-training-data huggingface dataset:
Protein: Dynactin subunit 2 (A8K8J9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
Protein: Bradykinin-like peptide RD-11 (P84824)
Organism: Ascaphus truei (Coastal tailed frog)
Function: Induces relaxation of mouse trachea that has been precontracted with methacholine. May induce relaxation of arterial smooth muscle. May target bradykinin receptors (BDKRB).
Subcellular location: Secreted {ECO:0000269|PubMed:15922344}.
Interaction partners:
Sequence:
RPPGFSPFRVD
Protein: Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Elongation factor G2) (hEFG2) (Q969S9)
Organism: Homo sapiens (Human)
Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03059}.
Interaction partners:
- Ribosome-recycling factor, mitochondrial
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein bL9m
Sequence:
MLTNLRIFAMSHQTIPSVYINNICCYKIRASLKRLKPHVPLGRNCSSLPGLIGNDIKSLHSIINPPIAKIRNIGIMAHIDAGKTTTTERILYYSGYTRSLGDVDDGDTVTDFMAQERERGITIQSAAVTFDWKGYRVNLIDTPGHVDFTLEVERCLRVLDGAVAVFDASAGVEAQTLTVWRQADKHNIPRICFLNKMDKTGASFKYAVESIREKLKAKPLLLQLPIGEAKTFKGVVDVVMKEKLLWNCNSNDGKDFERKPLLEMNDPELLKETTEARNALIEQVADLDDEFADLVLEEFSENFDLLPAEKLQTAIHRVTLAQTAVPVLCGSALKNKGIQPLLDAVTMYLPSPEERNYEFLQWYKDDLCALAFKVLHDKQRGPLVFMRIYSGTIKPQLAIHNINGNCTERISRLLLPFADQHVEIPSLTAGNIALTVGLKHTATGDTIVSSKSSALAAARRAEREGEKKHRQNNEAERLLLAGVEIPEPVFFCTIEPPSLSKQPDLEHALKCLQREDPSLKVRLDPDSGQTVLCGMGELHIEIIHDRIKREYGLETYLGPLQVAYRETILNSVRATDTLDRTLGDKRHLVTVEVEARPIETSSVMPVIEFEYAESINEGLLKVSQEAIENGIHSACLQGPLLGSPIQDVAITLHSLTIHPGTSTTMISACVSRCVQKALKKADKQVLEPLMNLEVTVARDYLSPVLADLAQRRGNIQEIQTRQDNKVVIGFVPLAEIMGYSTVLRTLTSGSATFALELSTYQAMNPQDQNTLLNRRSGLT
Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Q8AYH0)
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR002527}.
Interaction partners:
Sequence:
MTMTLHTKASGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVESNKTGVFNYPEGATYDFGTTAPVYGSTTLSYAPTSESFGSSSLAGFHSLNNVPPSPVVFLQTAPQLSPFIHHHSQQVPYYLENEQGSFGMRETAPPAFYRPSSDNRRHSIRERMSSASEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMMKQKRQREEQESRNGEASSTELRAPTLWTSPLVVKHNKKNSPALSLTAEQMVSALLEAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEERDYIHRVLDKITDTLIHFMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARSAAPMEEENRSQLTTAPASSHSLQSFYINSKEEESMQNTI
Protein: Ribosomal protein L37 (H0YVE2)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Interaction partners:
- Ribosomal protein S10
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL14
- Ribosomal protein L5
- Large ribosomal subunit protein uL11
- Small ribosomal subunit protein uS10
- Ribosomal protein L22 like 1
- Large ribosomal subunit protein P2
- 40S ribosomal protein S21
- Ribosomal protein L4
Sequence:
QTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKKVYRRFRYNILLTGITYGPSLHLEFSQH
Protein: Kinesin-like protein KIF13A (Q9EQW7)
Organism: Mus musculus (Mouse)
Function: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis (By similarity). Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11106728}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305|PubMed:11106728}. Midbody {ECO:0000250}. Endosome membrane {ECO:0000250}. Note=Recruited to the midbody during cytokinesis. {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-11A
- Stathmin domain-containing protein 1
Sequence:
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSKAEAMKPPELKEKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGISLETSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPEHCEIDIAADGDITLTPKENARSCVNGTLVCNTTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFERETSSAEHDLDAASEASSEPDYNYEFAQMEVIMKTLNSNDPVQNVVQVLEKQYLEEKRTALEEQRLMYERELEQLRQQLSPERQPPSSASDRLAYSSQTAQQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRKRGAIVSEPAIQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYGKRGDPFYEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIPERMAEDDSSENSSESGSLEVVDSSGEVIHRVKKLTCRVIIKEATGLPISLSNFVFCQYTFWDQCESTVAAPVVDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAGNGSPIWEVDSLHAKTRTLHDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTGGVFQLRQGHSRRVQVTVKPVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQEEDLNCVRERWSDALIKRREYLDEQIKKVSNKKEKTEDDMEREARLVEQWVGLTEERNAVLVPAPGSGIPGAPADWVPPPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATASWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKRIAANIYNKQSFTQSLKRRISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSENEGTLDGETYIEKYTRGVLQVENILSLERLRQAVTVKEALSTKARHIRRSLSTPNVHNVSSSRPDLSGFDEDDKGWPENQLDVSDYSSSYQDVACYGTLPRDSPRRSKEGCPSENPHALTVSPFKAFSPQPPKFFKPLMPVKEEHKKRLALEARPLLSQEDSEEEENELEALSRKLMLTQPYVPVEFADFSVYNASLENREWSSSKADLTDSRALEKAVSRSPTTSSLTSGYFSHSASNATLSDMAVPSSDSSDQLAVSTKEVECAEPPGPSLAPDVRRASNQELTEVGRGSGKDETIAVPLEENSALPKGTPSPQSIPEESSRMPCRTASCSELDVGPSKDGHQAREFCPGEVTIEHTTNILEDHSFTEFMGVSDGKDFDGLADCSVGEPSRRRALTNETDHKGIPERPPDADRLHPKIENDQEATATR
Protein: Protein PHOSPHATE STARVATION RESPONSE 1 (AtPHR1) (Q94CL7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in phosphate starvation signaling. Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes. SPX1 is a competitive inhibitor of this DNA-binding. PHR1 binding to its targets is low Pi-dependent. Regulates the expression of miR399. Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions. Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation. Required for the shoot-specific hypoxic response. Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis. Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency. Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation. Involved in the coregulation of Zn and Pi homeostasis.
Subcellular location: Nucleus {ECO:0000269|PubMed:11511543}. Note=The localization to the nucleus is independent of the Pi status. {ECO:0000269|PubMed:11511543}.
Interaction partners:
- SPX domain-containing protein 1
- SPX domain-containing protein 2
- Probable ubiquitin-conjugating enzyme E2 24
- Phosphate transporter PHO1
- Inorganic phosphate transporter 1-1
- SPX domain-containing protein 4
- Inositol-3-phosphate synthase isozyme 1
- SPX domain-containing protein 3
- E3 SUMO-protein ligase SIZ1
- SEC12-like protein 1
Sequence:
MEARPVHRSGSRDLTRTSSIPSTQKPSPVEDSFMRSDNNSQLMSRPLGQTYHLLSSSNGGAVGHICSSSSSGFATNLHYSTMVSHEKQQHYTGSSSNNAVQTPSNNDSAWCHDSLPGGFLDFHETNPAIQNNCQIEDGGIAAAFDDIQKRSDWHEWADHLITDDDPLMSTNWNDLLLETNSNSDSKDQKTLQIPQPQIVQQQPSPSVELRPVSTTSSNSNNGTGKARMRWTPELHEAFVEAVNSLGGSERATPKGVLKIMKVEGLTIYHVKSHLQKYRTARYRPEPSETGSPERKLTPLEHITSLDLKGGIGITEALRLQMEVQKQLHEQLEIQRNLQLRIEEQGKYLQMMFEKQNSGLTKGTASTSDSAAKSEQEDKKTADSKEVPEEETRKCEELESPQPKRPKIDN
Protein: Cystin-1 (Cilia-associated protein) (Q8R4T1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell projection, cilium membrane; Lipid-anchor. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus (By similarity). Expression is enriched in the ciliary axoneme. {ECO:0000250}.
Interaction partners:
- Cystathionine gamma-lyase
Sequence:
MGSGSSRSGRIPRRRRSPDRRQTGPGETASEGGTADQAPTAAGQEESGRDPRPATPSGGREETLRLLDQLLAESEAWGPQELTPRGPARLAPAVSPEKKVKGNPEDSCASEAPGNSPKRPEGQSAISYDYSEEELMASIEREYCR
Protein: U3-myrmicitoxin-Tb1a (U3-MYRTX-Tb1a) (A0A6M3Z4R1)
Organism: Tetramorium bicarinatum (Tramp ant)
Subcellular location: Secreted {ECO:0000269|PubMed:30149710}.
Interaction partners:
Sequence:
MKVLKFLFIAVIIVGLSGSLTWASPIANARAEADAEAAAEAVAKAVAEAVLPALPLLAGLMSLPFLQHKLTNG
Protein: N-alpha-acetyltransferase 35, NatC auxiliary subunit (Glucose repressible protein MAK10) (L-A virus GAG protein N-acetyltransferase subunit MAK10) (Maintenance of killer protein 10) (N-terminal acetyltransferase C complex subunit MAK10) (NatC complex subunit MAK10) (Q02197)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK10 has a role in the propagation of L-A and M viruses, perhaps in the viral assembly. It is apparently directly needed for optimum respiration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
- N-alpha-acetyltransferase 30
- N-terminal acetyltransferase B complex subunit MDM20
- N-terminal acetyltransferase A complex catalytic subunit ARD1
- N-terminal acetyltransferase B complex catalytic subunit NAT3
- N-alpha-acetyltransferase NAT5
- N-terminal acetyltransferase A complex subunit NAT1
- Small nuclear ribonucleoprotein-associated protein B
- Protein PET18
- ADP-ribosylation factor-like protein 3
Sequence:
MEVDSILGSLSITDDFDQLVDVTSLFDELCSKLKPEAIVKDPRFDLFEGTHSLEVNNSKLDSSLIELTAEEIEFDVNVAYDPPLASVAAIADRLLRCVISWLNDYQTLPTTVLSCRYTESLLSSLVKGTTAGSSWCTGNILYDKVLGSCILGVCYLTKFVQKLLSAGIVFEEEDLNFNNMGFNTFDNLPGQDVVINSLTESLQILEAYSDDSLHLTMLKHILKIIICLVHLEDHLTDYSTKTSHLDELIENANSVNGIFPQLQLSPPKGAFSTYIQKHRSNQFPPRKITKLPTDYSGFITLANDVKTILLVDKAESALETYQFAKFFNKLEQRHVIARILFPLFFIRDDRTVLGKFSYTQFYLLHVKEFSAQTPSEFESSIGNELIQESSNMLLEWYQNCSQNTCRYRQGFNRQLILWDSLQAQFESVNSQVYCSWTYFMKLSSMIEFSLKGFDLDIYKPFEAYSMFWYVYYLSHHLETFLKDSQNDIESNINAIHSMNKKLKKLKAGEKKDQLRLKYRFAMDNEMEQLQATKQFLNYLLKEINITKSLCLIEVFQFAILKSFGLIDNKNSTPSKFSNERLIHNLRFKPFNSIGVPELPEYEVFQQTLKDFVIEEKGAAFDIKLERATNFIETEVRNVVSSIDEIMQGIKGGDNNGVLVTGTRLVQELSLEYYCKLKHTSKALSVNSKVIVNTLKKNIKNKDSHEYKVELVHTTEGWNYFPIQTLRIKQDRYK
Protein: Bargin (Chimeric SH3BP1-PDXP protein) (Q6ZT62)
Organism: Homo sapiens (Human)
Function: GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23223568}; Peripheral membrane protein {ECO:0000305|PubMed:23223568}. Cytoplasm, cytosol {ECO:0000269|PubMed:23223568}. Note=Localization to membranes is increased by binding of poly-ubiquitin chains (PubMed:23223568). Enriched in tangle aggregates in cells of Alzheimer's disease brain (PubMed:23223568). {ECO:0000269|PubMed:23223568}.
Interaction partners:
Sequence:
MDRGLPGPATPAVTPQPPARPQDDEEAAAPHAAAGPDGQLGTVEQRLEPAKRAAHNIHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRSTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED
Protein: Pathogenesis-related thaumatin-like protein 3.3 (allergen Cry j 3.3) (Q8H994)
Organism: Cryptomeria japonica (Japanese cedar) (Cupressus japonica)
Function: May be involved in disease resistance.
Interaction partners:
Sequence:
RAIGVWIALVAALSVFLHGMEVRAATFDITNQCPYTVWAAASPGGGQQLDQGQTWTIQVAAGTTQARIWARTGCSFDGSGRGTCQTGDCNGMLSCQGYGQVPATLAEYALNQYMNLDFYDISLVDGFNVPLSMTPTSTDPNCKGRIACLSDINSQCPSDLKVTGGCKSACARYNTPEYCCTGASENTCGPTDYSKFFKGQCPQAYSYAKDDATSTFTCPSGTNYKVVFCG
Protein: Peroxisomal ATPase PEX6 (EC 3.6.4.-) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) (Peroxisome assembly factor 2) (PAF-2) (Q13608)
Organism: Homo sapiens (Human)
Function: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16854980}. Peroxisome membrane {ECO:0000269|PubMed:11355018, ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:26593283}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (PubMed:12717447, PubMed:16854980). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). {ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:26593283}.
Interaction partners:
- Peroxisome assembly protein 26
- Peroxisomal ATPase PEX1
- Peroxisomal targeting signal 1 receptor
- Peroxisomal membrane protein PEX13
- Peroxisome biogenesis factor 10
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX14
- Peroxisomal targeting signal 2 receptor
- Peroxisome biogenesis factor 2
- Peroxisomal biogenesis factor 3
Sequence:
MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGPDAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPPVVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLARVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGSIAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVPWLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
Protein: ABC transporter G family member STR (EC 7.6.2.-) (Protein STUNTED ARBUSCULE) (A0A0M3R8G1)
Organism: Petunia hybrida (Petunia)
Function: Together with STR2, required for arbuscule development in arbuscular mycorrhizal (AM) symbiosis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:D3GE74}; Multi-pass membrane protein {ECO:0000255}. Note=Located in the peri-arbuscular membrane of arbuscular mycorrhiza (AM). {ECO:0000250|UniProtKB:D3GE74}.
Interaction partners:
Sequence:
MAKFKRTDTNRSLENLLDQDKSAQMSKNGGSLAKQPTRKLIPGHGLEFNNLSYSVIKKVKKDGVWINKEAYLLNDISGQALRGEIMAIMGPSGAGKSTFLDALAGRIARGSLEGTVRIDGKPVTTSYMKMISSYVMQDDQLFPMLTVFETFMFAAEVRLPPSISRAEKKKRVHELLEQLGLTSATHTYIGDEGRRGVSGGERRRVSIGIDIIHKPSLLFLDEPTSGLDSTSAFSVVEKVKDIAKSGSIVLMTIHQPSFRIQMLLDRITVLARGRLVYLGSPTGVAAFLAGFARPVPDGENSLEYLLDVIKEYDESTVGLDPLVLYQRDGIKPDQAAKTPVRKPPKTPKIPRTPYAKSPWTKHISLKSSHFSTGNMNSQRDPKDHSDQQSDVNNFDYEDDDDEDEFDKSLERRAPHTPMSMQSGVYPRLASHFYKDFSVWLYNGVKGTPRRPPTWNNNGAIKAPISGSGFKSMSSSQFSMTQQTPGPGNKTPIFTPGRDVIEYSSYNPSYEEVFEIEEVLDEPVHRHKFANPWVREVLVLSWRTTLNVIRTPELFLSREIVLTVMGLVLSSFFKKLSHFDFKTINHLLNFYIFTICLVFFSSNDAVPTFIQERFIFIRETSHNAYRASSYVISSLIVYLPFFAIQGFTFAGITQYILHLNSSILSFWLILYSSLVTSNAYVMLVSALVPSYITGYAVVIATTALFFLTCGFFLKRTQIPLVWRWLHYISAIKYPFEALLINEFKGSKHCYDGDLSDLSPGPLGDVKFSALRNNSRAALPQNCTLIGEDVLFSMDIREENIWLDIVILLAWGVLYRLFFYVVLRFYSKNERK
Protein: Pre-mRNA-splicing factor SPP382 (CLF1 complex factor 8) (Nineteen complex-related protein 1) (NTC-related protein 1) (Suppressor of PRP38 protein 2) (Q06411)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor NTR2
- Pre-mRNA-splicing factor BUD31
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Pre-mRNA-splicing factor CWC23
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor SNU114
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor 8
- Pre-mRNA-splicing factor SYF2
Sequence:
MEDSDSNTDKKFFFKKRRIDSYNYSDEEDNNSSMNSDMTYTNDALKTSSGNAPTISKLTKTYGIGAKLLSSMGYVAGKGLGKDGSGITTPIETQSRPMHNAGLGMFSNTNSSNYHSENEDYLSSEDEVVEGIEQVKFNKTSTEVLGEALLNDSGDMTIVRTLRELRLAGVQLPESILKELDPLNAVPKPKKDVVVEILQELLGIEKSLEAIRQRTSPLEVQVKEYYGQERLLSELEVTLRDESKHVSLYDKIGAILKLSDDELIDRLTSCLLRKELLIEFDLDHLEKPNDILDELTQIIELLAYRMDTTSKFLNRTQTTIFKVIYPKLKKFWEGFDMTKSKIDSAITLLLDFQQVLSFIGCKEHIMEEFVYPKLLQELDNWELHDEVDHVSPRIWVLDFMVLIDDKIKDTIVDKIEAKFFAYCKNWYHRESFCITNSDIIFIKELICERRYYKILCKEFLPKFLDELWERHNDPIYELEDWKEKQEWKEKDSGFFYFMKKLRSYTHYFHPKQYELMMRGTFNNINKILYQWHLYSTVEDLHKSKWWLNWLMNTVFEHSLPTEIELSEIRKSYNIFAMSHRYHLDKSTLDEDFDLRQGLRNLMETQVIDDISQSEQEPTYTVQNIPLGKVSSSFKDVVEDYCLEKGYLISKIPNRYTQLPYGRDQDCIVPLFEIRNGKKKMEVALKHDILWVEDSSGTFKPIYLWALDL
Protein: Gastrin-releasing peptide (GRP) (Q9PS30)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Stimulates the release of gastrin and other gastrointestinal hormones.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P07492}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}.
Interaction partners:
Sequence:
SENTGAIGKVFPRGNHWAVGHLM
Protein: Melanophilin a (E7F2P6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDKKLDLSRLSEEEAKHVWEVIQRDFVLRKKEEERLGELKTKIEKEEAKRELLGSQSNLSESHCIRCLQPFKFLVNSRRQCVDCKLFTCKTCSRYNKNEHGWVCDPCRMSRVLKIGTLGWYHDNVHSRFKRFGSAKVMRSLYKRLNEEGHRDDDTQSMPDVRNAYNGHDEEHMDASEAQRYKQMRKTKRLLSVHPMDLEIDDYAVHSRRQSVQYIHDDRGQRNDLEYNSEIYHQHQQRMNRRKSLDRFSRPDDGLYSENRMVRARSLSKINSSMAPRQIYLDTSEEEDMYRYPVYQLPPRRRSRASSQENIQQGAPPINELSKRMSAIESLLNRLEEKITVPSDQPALPPAGHMEEEKLRRKLDELMSDKGLSSDEEDPKRAPQYKRSTVRGDQTAMVLASQEPLSSSSDEMPTEAQKVYMTAGKSYEVAKKLQKIEHNAKNHYGGPLTDSELSELEDQVALAVAKVQGTESEVSDIESKLAALSAKGLSIDKAKKKAVSMQQKRKFPQDFSSSRVHF
Protein: Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) (Q6AYT0)
Organism: Rattus norvegicus (Rat)
Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- NAD
- Heme oxygenase 1
- Nuclear factor erythroid 2-related factor 2
- Kelch-like ECH-associated protein 1
- Glutamate--cysteine ligase catalytic subunit
- Glutamate--cysteine ligase regulatory subunit
- Glutathione peroxidase 1
- Glutathione peroxidase 2
- Epididymal secretory glutathione peroxidase
- Glutathione peroxidase 3
Sequence:
MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPAPQSHQVLIKVHACGVNPVETYIRSGTYSRKPALPYTPGSDVAGIIESVGDGVSAFKKGDRVFCFSTVSGGYAEFALSADNTTYPLPETLDFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKTSAGDKGVDVIIEMLANKNLSNDLKLLSCGGRVIVVGCRGSIEINPRDTMAKETSIIGVSLFSSTKEEFQQFAGILQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHSSGKMGKMILLL
Protein: Mannosyltransferase regulator 14 (P40355)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMLSLRRFSMYVLRSLRLHFKKIIITLLTIQLLFITIFVLGGRSSIIDGNWKSFMALFFKPLAYTNRNNNHASFDLRSKDNVAKLYEKMNFDTSGKWIDTYTLKNNLLTVKMGPEKGQVLDSVDELRYYDNDPRLVWSVLLDHLLESDSNEYAFSWYDWANFDSTNKLIALRHTNISCQFVCEGAFDKNVLEMVESEVQEPLFVTNRNKYDESLWYNRVRKVVDSNSVQQAIHDHCMNNDAYSNGTPFELPFIISEISERLRPEVYDLQAKNHLLYSNFTPLSLTVLDSDKDAYRINLKTTDSSKSNIVQTNLLQNYIKRHRNEMVNGDLIFNHTSMFEKFLHHGSTKKRKLDVEALDKTIYAGEYLELSPSDFQFNAKERIIELETRLRSEGLPSHDTHYLRSLKTSVNTSPALQQKYFAEASDITDATADGHHRDRRFFSIGHNLLNDPQEFEARLNSLIRNFQKFVKANGLISWLSHGTLYGYLYDGLKFPWDVDHDLQMPIKHLHYLSQYFNQSLILEDPREGNGRFLLDVGSAITVGVHGNGENNIDARFIDIDSGIYIDITGLSVSSDAAKQYMSKFVEEESSGESFSALIEDYKFDENDYFDEVDGREGLAKYTIHELMEWVNSHPDDFTDAEKNLVTKTYKKELAISRSDYAEKDLSPKQRYLVNEKYNLYNCRNQHFSSLNIISPLRNTMFSGVSAFVPNRPIATLNNEYKVPAKYGLLSFQGKVYLPEFRYWFSFADMKKFANLQLKEPKITRLESPLNDLKFSDISLLITNILKCGFHSVFASLFNSFDSTVYRLKELEIQYDPSLSEEEKSSLLKTLRRGMSKKIKSPEKDPIIYIYERKLWENVEKLLNASNIYNIASQVEKEKGKEFVERSQQVYERNFDGFRLPDGGNSKTVNDLNSKGLNLFGDNKKTSNNIFGSDQKY
Protein: GTP-binding protein RAD (RAD1) (Ras associated with diabetes) (P55042)
Organism: Homo sapiens (Human)
Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Subcellular location: Cell membrane {ECO:0000250}.
Interaction partners:
- Early growth response protein 1
- E3 SUMO-protein ligase EGR2
Sequence:
MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAAAGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL