wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) (P05023)
Organism: Homo sapiens (Human)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VDN2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P06685}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit beta-3
- Sodium/potassium-transporting ATPase subunit beta-2
- Protein ATP1B4
- Sodium/potassium-transporting ATPase subunit alpha-3
- Mitogen-activated protein kinase 1
- Phospholemman
- Mitogen-activated protein kinase 3
- Sodium/potassium-transporting ATPase subunit alpha-2
Sequence:
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
Protein: Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) (Q9JLF6)
Organism: Mus musculus (Mouse)
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P22735}; Lipid-anchor {ECO:0000250|UniProtKB:P22735}.
Interaction partners:
- Periplakin
- Envoplakin
- Magnesium transporter NIPA4
- Involucrin
- Loricrin
- Corneodesmosin
- Filaggrin
- Hydroperoxide isomerase ALOXE3
- Omega-hydroxyceramide transacylase
- Repetin
Sequence:
MEGPRSDVGRWGRSPWQPPTTPSPEPEPEPEPDRRSRSRRGGGRSFWARCCGCCSCGNRGDDDWGPEPSGSRSRGTSSRGRDSRGGRRPESRGSGVNAAGDGTIREGMLVVTGVDLLCSRSDQNRREHHTDEFEYDELIVRRGQPFHMILFLNREYESSDRIALELLIGSNPEVGKGTHVIIPVGKGGSGGWKAQVTKNNGHNLNLRVHTSPNAIIGKFQFTVRTRSEAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVSVSRVVSAMVNSLDDNGVLIGNWTGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGFATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESVKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAIHSNNREDITHIYKHPEGSEAERRAVEKAAAHGSKPNVYATRDSAEDVAMQVEAQDAVMGQDLAVSVVLTNRGSSRRTVKLHLYLCVTYYTGVSGPTFKEAKKEVTLAPGASDSVTMPVAYKEYKPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECGVQIVFKNPLPVTLTNVVFRLEGSGLQRPKVLNVGDIGGNETVTLRQTFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPASGGSGFSDAGGDSRSGENIPMAYRGGA
Protein: acetyl-CoA C-acyltransferase (EC 2.3.1.16) (G8BBD5)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
- acetyl-CoA C-acyltransferase
- Hydroxymethylglutaryl-CoA synthase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Peroxisomal hydratase-dehydrogenase-epimerase
- methylmalonate-semialdehyde dehydrogenase
- Acyl-CoA dehydrogenase NM domain-like protein
- Citrate synthase
Sequence:
MESLNNLNGQVKDHTKKDILEKHPDDVVIVAAYRTPIGKGFKGSFRSVGTDFILTEFLKEFLAKTKVDPKLIEDVAIGNVLNPGIGAFEHRSAALAAGIPYTAGFVAVNRFCSSGLMAISDIANKIAVGEIDCGLAGGVESMSKYYKKTIPQFDPHLADREEVSSCLIPMGITNENVANKYNVSREAQDAFAAKSYNKAENAIATGKFKEEILPIRSIIRDGKSEKEIIVETDEGPRKDVNPAGLGKLPPAFGGSTTAGNASQISDGAAAVLMMKRSFAEKNGYPVLAKYVACSVSGVPPEIMGVGPAFAIPEVLNRTGLKVDDIDIFEINEAFAGQCLYSIQSVGIDEDKVNLNGGAIALGHPLGTTGARQYATILPLMKPGQIGVTSMCIGTGMGAASVLVRE
Protein: Regulatory protein NPR3 (BTB/POZ domain-containing protein NPR3) (Q8L746)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens.
Subcellular location: Nucleus {ECO:0000269|PubMed:17076807}.
Interaction partners:
- Transcription factor TGA2
- Cullin-3A
- Transcription factor TGA5
- Transcription factor TGA6
- Transcription factor TGA3
- Cullin-3B
- Transcription factor TGA1
- Protein NIM1-INTERACTING 1
- Transcription factor TGA7
- Probable WRKY transcription factor 70
Sequence:
MATLTEPSSSLSFTSSHFSYGSIGSNHFSSSSASNPEVVSLTKLSSNLEQLLSNSDCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQLREMLPYGAVAHEAFLYFLSYIYTGRLKPFPLEVSTCVDPVCSHDCCRPAIDFVVQLMYASSVLQVPELVSSFQRRLCNFVEKTLVENVLPILMVAFNCKLTQLLDQCIERVARSDLYRFCIEKEVPPEVAEKIKQLRLISPQDEETSPKISEKLLERIGKILKALDSDDVELVKLLLTESDITLDQANGLHYSVVYSDPKVVAEILALDMGDVNYRNSRGYTVLHFAAMRREPSIIISLIDKGANASEFTSDGRSAVNILRRLTNPKDYHTKTAKGRESSKARLCIDILEREIRKNPMVLDTPMCSISMPEDLQMRLLYLEKRVGLAQLFFPTEAKVAMDIGNVEGTSEFTGLSPPSSGLTGNLSQVDLNETPHMQTQRLLTRMVALMKTVETGRRFFPYGSEVLDKYMAEYIDDDILDDFHFEKGSTHERRLKRMRYRELKDDVQKAYSKDKESKIARSCLSASSSPSSSSIRDDLHNTT
Protein: Glycine-rich RNA-binding protein 2, mitochondrial (AtGR-RBP2) (AtRBG2) (Glycine-rich protein 2) (AtGRP2) (Mitochondrial RNA-binding protein 1a) (At-mRBP1a) (Organelle RNA recognition motif-containing protein 5) (Small RNA binding protein 3) (AtSRBP3) (Q9SVM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes the cis-splicing and editing of several mitochondrial RNAs (including NAD5 transcripts). Plays a role in RNA transcription or processing during stress. Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids. Displays strong affinity to poly(U) sequence. Exerts cold and freezing tolerance, probably by exhibiting an RNA chaperone activity during the cold and freezing adaptation process. Mediates cell-to-cell trafficking of RNA interference (RNAi) signals (small RNAs (sRNA), e.g. small interfering RNA (siRNA) and microRNA (miRNA)) which regulate growth and development, as well as responses to environmental inputs, including pathogen attack; can compromise zucchini yellow mosaic virus (ZYMV) and tobacco rattle virus (TRV) infections at the early stage.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:11972043, ECO:0000269|PubMed:14671022}. Secreted {ECO:0000269|PubMed:31812689}. Note=Observed in the phloem translocation stream. {ECO:0000269|PubMed:31812689}.
Interaction partners:
- Cold shock protein 2
- Probable transcription factor At1g61730
- RNA-binding
- Pentatricopeptide repeat-containing protein At3g48810
- Zinc finger CCCH domain-containing protein 21
- Pentatricopeptide repeat-containing protein At1g20300
- Surfeit locus protein 1-like
- KH domain-containing protein At3g08620
- B3 domain-containing transcription factor VRN1
Sequence:
MAFCNKLGGLLRQNISSNGNVPVTSMLGSLRLMSTKLFIGGLSWGTDDASLRDAFAHFGDVVDAKVIVDRETGRSRGFGFVNFNDEGAATAAISEMDGKELNGRHIRVNPANDRPSAPRAYGGGGGYSGGGGGYGGGGGGYGGGGGGYGGGGDGGGGF
Protein: Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Q3UUV5)
Organism: Mus musculus (Mouse)
Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86WV1}. Nucleus {ECO:0000250|UniProtKB:Q86WV1}. Cell membrane {ECO:0000250|UniProtKB:Q86WV1}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000250|UniProtKB:Q86WV1}.
Interaction partners:
- FYN-binding protein 1
- Lymphocyte cytosolic protein 2
- T-cell surface glycoprotein CD3 zeta chain
- Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
- Linker for activation of T-cells family member 1
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 delta chain
- Ras-related protein Rap-1A
- Tyrosine-protein phosphatase non-receptor type 6
Sequence:
MQAVALPEEICWLLEDTEDFLAEGLQNENLSPGAQDQRAHILRGFQQIKSRYCWDFQPQGGDLGQDGSDDNLSGTHGPPLTSEASFWSDYQDEGIEDILRGAQELDSVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGYSVRMAPHLRKDSKKESCFELISQDRRSYEFTASSPAEARDWVDQISFLLKDLSSLTIPFEEEEEEEEEEEKEEEEMYNDVDGFDSPRSGSQCRAMALPEPTEKEEDIYEVLPDDDDLEEDTCGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSVIGIVPKDYLTTAFEMEGI
Protein: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (Q86BP1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 3-hydroxyisobutyrate dehydrogenase, mitochondrial
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS15m
- LD06441p
- Probable enoyl-CoA hydratase, mitochondrial
- Cytokine-like nuclear factor N-PAC
- Large ribosomal subunit protein mL43
Sequence:
MQGPIQRLVYTFGHRTCSQLPMIGGATISQTKPTTMALSVRQSSSSVLATESSNKGMIILNRPKALNAINLEMVRKIYKHLKKCEKSKSLVIIKGTGDKAFCAGGDVRALVEAGPTDESKSFFREEYSTNALIGNYKIPYIAIIDGITMGGGVGLSVHGKYRVASDRTLFAMPETAIGLFPDVGGSYFLPRLQGKLGLYLGLTGYRLRGADVYYSGIATHYCESSKIPDLETALLNCPDADDVPELLQKYHSPPEKPFSLQPVLEQINKNFSADSVEGILENLQNDGSEWAKKTLETLSKMSPTSMKVTFRQLELGSQLSLAQCLIMEYRLAVRHLERSDFKEGVRALLIDKDQKPQWQPTKLADVTEEHVQWFFRKLPDTEELKL
Protein: Lecithin-cholesterol acyltransferase-like 4 (EC 2.3.1.-) (Q71N54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phospholipase A2-alpha
- Lysophospholipid acyltransferase 1
- Non-specific phospholipase C1
- Choline/ethanolaminephosphotransferase 2
- Triacylglycerol lipase SDP1
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Lysophospholipid acyltransferase 2
- Choline/ethanolaminephosphotransferase 1
- Triacylglycerol lipase SDP1L
- Phosphatidylserine decarboxylase proenzyme 3
Sequence:
MSLLLEEIIRSVEALLKLRNRNQEPYVDPNLNPVLLVPGIAGSILNAVDHENGNEERVWVRIFGADHEFRTKMWSRFDPSTGKTISLDPKTSIVVPQDRAGLHAIDVLDPDMIVGRESVYYFHEMIVEMIGWGFEEGKTLFGFGYDFRQSNRLQETLDQFAKKLETVYKASGEKKINVISHSMGGLLVKCFMGLHSDIFEKYVQNWIAIAAPFRGAPGYITSTLLNGMSFVNGWEQNFFVSKWSMHQLLIECPSIYELMCCPYFKWELPPVLELWREKESNDGVGTSYVVLESYCSLESLEVFTKSLSNNTADYCGESIDLPFNWKIMEWAHKTKQVLASAKLPPKVKFYNIYGTNLETPHSVCYGNEKMPVKDLTNLRYFQPTYICVDGDGTVPMESAMADGLEAVARVGVPGEHRGILNDHRVFRMLKKWLNVGEPDPFYNPVNDYVILPTTYEFEKFHENGLEVASVKESWDIISDDNNIGTTGSTVNSISVSQPGDDQNPQAEARATLTVQPQSDGRQHVELNAVSVSVDA
Protein: Metabotropic glutamate receptor 7 (mGluR7) (P35400)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14831}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14831}.
Interaction partners:
- Metabotropic glutamate receptor 8
- ANF_receptor domain-containing protein.
- PRKCA-binding protein
- Metabotropic glutamate receptor 2
- Glutamate receptor ionotropic, NMDA 2A
- Guanine nucleotide-binding protein G
- Metabotropic glutamate receptor 3
Sequence:
MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
Protein: DNA replication and repair protein RecF (P9WHI9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Beta sliding clamp
- DNA gyrase subunit B
- Chromosomal replication initiator protein DnaA
- UPF0232 protein Rv0004
- Ribonuclease P protein component
- DNA gyrase subunit A
- Recombination protein RecR
- Replicative DNA helicase DnaB
- DNA repair protein RecO
- Protein RecA
Sequence:
MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALWYSTTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSVRSTRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVLRQRTALLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQLLAPESRSASIGYRASMDVTGPSEQSDIDRQLLAARLLAALAARRDAELERGVCLVGPHRDDLILRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVMRRRALATAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP
Protein: Schlafen-like protein 2 (SLFL-2) (SLFN-like 2) (EC 3.1.-.-) (21U-RNA biogenesis fouled up protein 2) (PUCH complex member slfl-2) (Protein tofu-2) (Q19614)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000269|PubMed:31216475}. Mitochondrion {ECO:0000269|PubMed:37758951}. Note=The localization to the mitochondrion is mediated by slfl-3. {ECO:0000269|PubMed:37758951}.
Interaction partners:
- Schlafen-like protein 1
- K Homology domain-containing protein
- Twenty One u-rna
- Uncharacterized protein E02H1.5
- Embryonic developmental protein tofu-6
- RNA-splicing ligase RtcB homolog
- Ubiquitin-like protease family profile domain-containing protein
- Uncharacterized protein
- Twenty One u-rna
- Enhancer of rudimentary homolog 2
Sequence:
MADTSPRESKLNKQDQDLHLEIDETGLACKSEVKKRWLGARGTAGLYGNGKYYYEVTITSKGLCRVGWATLGGSLNIGKGLDSFGYGGTGMKSTHKKFDDYGLPFTLNDVIGCYLDLDSRTIWWSKNGEQFPAAFSIDVKYKNSNTCLFPAVLCQNSSLSVNFGSQPFKFPPGNQFTAVSDAPNENVNWWSYEEQNSFEHVVVKLPFAVEEDVHNEFRMHTKLMLTELKRTQCKQDKDGSIRRTLQPISKTICAFLNTDGGRLFLGVNDDKVIKGISMSKNMIYHFFGSLRHMCENFKPCSPLCRIKVSILEVIPVGVIKVKLRKADLLKEEAHDFPKLACHSVGGSFCDCFLEINKAPTKQYLLIIQVSPPNPNSRTTIFQNEEGLVYRRRMASNKCVYLDDLRRMMNEKNQVFVDLPDEARAEIDSFSKFD
Protein: Probable transmembrane protein (O50451)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Trehalose-binding lipoprotein LpqY
- Trehalose transport system permease protein SugA
- Trehalose import ATP-binding protein SugC
- Trehalose transport system permease protein SugB
- Multidomain regulatory protein Rv1364c
- Probable lipoprotein LpqZ
- Possible osmoprotectant binding lipoprotein ProX
- Putative acetolactate synthase large subunit IlvB2
Sequence:
MTSPFQPRQVPGSTPAAAGAGRRGVPALPTPPKGWPVGSYPTYAEAQRAVDYLSEQQFPVQQVTIVGVDLMQVERVTGRLTWPKVLGGGVLSGAWLGLFIGLVLGFFSPNPWSALVTGLVAGVFFGLITSAVPYAMARGTRDFSSTMQLVAGRYDVLCDPQNAEKARDLLARLAI
Protein: Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) (Q8IVB4)
Organism: Homo sapiens (Human)
Function: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity).
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:15522866}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Early endosome membrane {ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Recycling endosome membrane {ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cell membrane {ECO:0000250|UniProtKB:Q8BZ00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8BZ00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Note=Localized to the plasma membrane in inner ear hair cell bundle. {ECO:0000250|UniProtKB:Q8BZ00}.
Interaction partners:
- Dedicator of cytokinesis protein 3
- Divergent protein kinase domain 2A
- Small ribosomal subunit protein RACK1
- Sodium/hydrogen exchanger 9B2
- Neuronal PAS domain-containing protein 4
Sequence:
MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLDKNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAYGEQLKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGDLGLGGYELKLEQTLGQSQLN
Protein: Myocyte enhancer factor 2aa (Myocyte-specific enhancer factor 2A isoform X9) (A0A0R4IRM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDASYVLTPHTEEKYKKINEEFDNMMRNHKIPTALPPQNFSMHVAVPVTNPNAMSYNPGASLSSQSLSAAASLSDGAMLSPPQGSMHRSVVPPQRPPSTGSTAGNGFVNPRGSPGLLGTPSGNGLGKVMPAKSPPPPGGNMGIGSRKPDLRVVIPPSSKGMMPPLNTQRISSSQSTQPLATPVVSVTTPSLAPQGLVYSGMPTAYNSEYSLSSAELSSLQGFGSPGLSIGSVSAWQQHQLGQAALSSLVGGGHLPQGSNLSINTSQNVNIKSEPISPPRERVTPSGFPPQQQQPPSGRPDMGRSPVDSLSSSCSSYDGSDREDHRPDFHSPLGLGRPPAGGADERESPSVKRMRMDTWVT
Protein: 25S rRNA (cytosine(2278)-C(5))-methyltransferase (EC 2.1.1.311) (rRNA m(5)C methyltransferase 1) (P53972)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2278 (m5C2278) in 25S rRNA. Loss of m5C2278 in 25S rRNA results in anisomycin hypersensitivity.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10649453, ECO:0000269|PubMed:23913415}.
Interaction partners:
- Putative methyltransferase YGR283C
- Putative methyltransferase YMR310C
- Protein-lysine N-methyltransferase EFM2
- 25S rRNA
- 60S ribosome subunit biogenesis protein NIP7
- Methionyl-tRNA formyltransferase, mitochondrial
- 25S rRNA
- rRNA-processing protein EBP2
- 25S rRNA
- UPF0743 protein YCR087C-A
Sequence:
MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNPKHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLSEDISNDLPPVRWIRINPLKCHPNGETEPVLAELRKKFTLKVDKWSELVPGSIYYDEFIPNLFGIHPSDKITAHELYKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSGIFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAMSFPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEFEEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD
Protein: Protein transport protein sec61 subunit beta (O43002)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Necessary for protein translocation in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable protein transport protein Sec61 subunit gamma
- Protein transport protein sec61 subunit alpha
- Translocation protein sec62
- Uncharacterized protein C19G7.17
- Translocation protein sec63
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost2
- Large ribosomal subunit protein eL31
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1
Sequence:
MSSTKASGSVKNSAASAPGGPKSQIRRRAAVEKNTKESNSGPAGARAAGAPGSTPTLLKLYTDEASGFKVDPVVVMVLSVGFIASVFLLHIVARILKKFASE
Protein: Histo-blood group ABO system transferase (Cis-AB transferase) (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) (P38649)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- Alpha-
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- Galactoside 2-alpha-L-fucosyltransferase Sec1
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Sequence:
MNLRGRPKCNFLHLGILPFAVFVLVFFGYLFLSFRSQNLGHPGAVTRNAYLQPRVLKPTRKDVLVLTPWLAPIIWEGTFNIDILNEQFRIRNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRWQDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSSSREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIEPVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN