wanglab/gogpt-training-data huggingface dataset:
Protein: Surface-adhesin protein E (A4NBN9)
Organism: Haemophilus influenzae (strain NTHi 3655)
Function: Acts as a multifunctional adhesin involved in direct interactions with host epithelial cells and host proteins, including vitronectin, laminin and plasminogen. In addition, interaction with serum vitronectin plays an important role in bacterial serum resistance, and conversion of plasminogen to plasmin at the cell surface aids in immune evasion and contributes to bacterial virulence. Induces a pro-inflammatory epithelial cell response, leading to interleukin-8 (IL-8) secretion and up-regulation of ICAM1.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:18069033}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:18069033}. Cell surface {ECO:0000269|PubMed:18069033}.
Interaction partners:
Sequence:
MKKIILTLSLGLLTACSAQIQKAEQNDMKLAPPTDVRSGYIRLVKNVNYYIDSESIWVDNQEPQIVHFDAVVNLDKGLYVYPEPKRYARSVRQYKILNCANYHLTQVRTDFYDEFWGQGLRAAPKKQKKHTLSLTPDTTLYNAAQIICANYGKAFSVDKK
Protein: Cyclin dependent kinase like 5 short (Cyclin-dependent kinase-like 5) (B9X2H5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKIPDIGNVMNKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLGIINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTPPRSSKRKPYHGDNTIPSRSHGSKSSSHRRANSKDCSSLPRHEDLHRSTDSFLNGTNMPTSSTLSPTLHPKSYQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLGPKVGVASVGMDTSTGKYLKSSKQGRHSSFLEGKTSTLQSGDKHSRHNYMESSHGSMPSTSSSKSSSSFLSLSKSHGALNDAKSVSNLAETRLHLDDPMAGSGSGSRYFPSSCLDLNAAPGSPRGERHAGTERQGHSPSGRGSNRLEGGTLDSRRSSGRKKTPDEPKPTDTLDPSRAAGGHAHNLPSPHESYPYGLGYTSPFSSQQRPHRHSMYVRRERHRPHGQENNLVVGQGVPTRASSLQLLSPQLQHRTLPRHNTSSSREELTPELSRNDQSPKEKPHSRPLIKDSTRDNTATFHTQRPKNEAGMYHDAHMEDGTSSKENRIIYSDSMPRRVGSFYRVPSPRPDNTFLETTGQSRVQAVAAENPTMTNHSKRQTNFDPWNNSEAMVMNPPEVPKQKEKQGFFRAIKKKKKKSQPVPSETQQDQLVLQRPVKSSSHHSSRHRNRDRERERDMERDRERERDRNRDRDRERDRDNTWPPEKQPEVQPQNQPLKSLRKLLHLSSPATSNQPPPPDRSAELRFQPLPNPPSKANLNEVRGHPAGSVTPNTKSRKPHNYPLPGQIESSWHVSALNRAEGAPYPDQLANKGGQNGIGFTRAARTRMPNLNDLKETAL
Protein: Programmed cell death protein 4 (Q7ZVK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATDCEAWLNANPVEAGNLSDSFPSGDEDSTFTANVNNEINGNWISAPTSTIHEARLKAKVKRRLRKNSSRDSGRGDSLSDNGEAVRSVVPPTSPKGKLLNRRSRTGKGRGLPKKGGAGGKGVWGTPGEVYGEDEVDYKDPNYDAEQENCVYETVVLPLDEEAFEKTVTPIVQEYFEHGDANEVAELLAELNLGSMRGDVPMLAVSLALEAKASHRELTSRLLSELCGRVLTAGDVQASFHKLLKELPDLVLDTPGAPQMLGQFIARAVADSILPKTFLDGYKGRVDCEYARAALDRAAVLLRMSRWTGLRIDSLWGSGGGQRPVTQLIKEVNLLLKEYLLSGDTVEAERCLRELEVPHFHHEFVYEAVIMVLESTGERTLQMLLQLLKCLCSSTIITVDQMRRGFERVYLDMPDISIDVPCAYSILEQFVEQSFNAGVIDRKLRDLCPSRGRKRLISEGDGGHLKLQNY
Protein: Binding protein (Impaired sucrose induction 1) (Q84J43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Sugar transporter ERD6-like 5
- Nucleoporin-like protein
Sequence:
MYLKRPIWSDGASATPENPSESETGEESDAASMVVEELVTSLNTQRLYRELTLSLRTGLRDACAEFSFLRIRGLRSLLKTLRTVADSDSIIRLFSHTQTISDLQLVPVLFQHSLKEAEDDKVTSLDHIFSVEPMKITSPSTDAEVAVALRVLEGCCLLHPQSTVLAHKHGAVRVMMNVLSTRGVLEQGACLDALISVLLDSSANQVDFGACNGIEEVAMLMRDKQADENLRLRCGEFLLLLVGHVNGKDRSPIASVNEDIRRLLGEKSASLIWAASQFGSTGDPEQRITALHIQAGRVLESLDLY
Protein: Narrow abdomen, isoform G (R9PY25)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIDRLQIRRLGAAARNKRAGGGGGAGGGAVGSGGAGGGGGGGGAGAVPGAAGAAGTGPITGASATAASGSSGSGGHHQHHHHSHPYSTSGINTPATASTSSSSGNSLTPQQQQQQQHPHHQSHHGHHYAHHQQHTHHHAPPHSHHPHPHPHGHPHSYPHLRHSQPASASQFSFNPSPGSSPGNGLGLGARQDAASALNSPTTIVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGGGGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGWRLVTIDDNKHGGLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKNVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSPSAMMSQMIGGSGKLLPFNNQANAVYEVHDWWQEQVLCPQTSDDEI
Protein: Cell division ATP-binding protein FtsE (O34814)
Organism: Bacillus subtilis (strain 168)
Function: Part of the ABC transporter FtsEX involved in sporulation. May act as an importer, possibly at the top of a hierarchical cascade leading to the correct temporal initiation of sporulation. Acts upstream of the histidine kinases KinA, KinB and KinC, the RapA phosphatase and the Spo0A sporulation protein.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18573177}; Peripheral membrane protein {ECO:0000269|PubMed:18573177}. Note=Unlike the E.coli ortholog, localization is not restricted to division septa, nor is localization dependent on FtsZ.
Interaction partners:
- Cell division protein FtsX
- Cell division protein FtsA
- Cell division protein FtsZ
- Probable peptidoglycan glycosyltransferase FtsW
- DNA translocase SpoIIIE
- Peptidoglycan DL-endopeptidase CwlO
- Cell division protein ZapA
- Uncharacterized ABC transporter permease YknZ
- Uncharacterized ABC transporter permease YvrN
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydC
Sequence:
MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTFIKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAFALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVIADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRDESRGEYGSYD
Protein: MIF4G domain-containing protein (Q383M3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable eukaryotic initiation factor 4A
- Eukaryotic translation initiation factor 4E, putative
- Eukaryotic translation initiation factor 4E, putative
- Eukaryotic translation initiation factor 4E, putative
- Eukaryotic translation initiation factor 4E, putative
Sequence:
MLFKPRGVTSNDPRYAGGSRLMSVSDLLAYRDTWRGRPPTESFSLAQILRDARAADCKPVVTEKLVMSENGFKVKSRDSIDSLERGVRAVQSALNKLTEWNFDVVVQTVLTPDIIINNEVVKDVVRLIYEKALMEPVFAGLYARMCFSIVRFEYEYRTKFLPGTCQVPSAVRVAIVEKCQQMFTNAVEESKQTMSEEQAERLRKRNVNNIKFAGELFLKTLITQKIIDRILNERIYEMVPNDMELEVIINLLEVVGKLYEEKNPDAQEQLWKMLSSMQENRRYSMRIRFLLQNLIDRRNGGWKPREPEQVVIEDIQSQQQPQQQSQQQQQQQQQQQSQQQPQQQQQQGQKHYSQQQRHQQSFPHHNQPQSHGGYHQHPPPPPPPPRNSEYQHTPGMKRGGSYHEVSSSLGMGGRCSQSTNDLTRGGSYNNMPPPAHGFSDSRLAPEERKRLNFARPPAQLLEEFKKNILFIVRDAAEEGMADPEGMKVQLNALVPQDSNAPISEVSVYVTLIRALMDANESERKLLLSVLQKGSFENHILTRGFSWALAKIISDRDCDDCPRIYARFAEAVWSIPSFNFRCVTKDIVSRTAIHLGALSVEYESEGEWEEDFIAVWENIVTASETGRQGESKPSVADMMESIAPSCTVPFMCNVLPDFVAVMVQARFFTEEELGAWRNKNKDNSKVFSLLEELSVIYA
Protein: Inflammation and lipid regulator with UBA-like and NBR1-like domains (Q5TH58)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSFVEDVTIGEGESIPPDTQFVKTWRIQNSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLKDPGGSEFDSISKNTWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSHANNLSVVTYSKGLHGPYPFGQS
Protein: H/ACA ribonucleoprotein complex non-core subunit NAF1 (Q9LR70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2-like protein
- H/ACA ribonucleoprotein complex subunit 3-like protein
- H/ACA ribonucleoprotein complex subunit 4
- Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1
- H/ACA ribonucleoprotein complex subunit 1-like protein 2
- Putative rRNA 2'-O-methyltransferase fibrillarin 3
- Nuclear pore complex protein NUP155
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein
- At4g22380
- Pentatricopeptide repeat-containing protein At1g10270
Sequence:
MVGFPANQAKTVEEELPLQVVADQDPKVKTFKDSFDFPSIDSFPDFDSITWSESNRNVEDFSIEDTDFDFFEYHMEIPQEDVVTVSDVMCPENQTTVNSESIEGKLEVFNDDMSGEVGVSSVRSESMVEVKPVLCDVMSEEVGVSSVEVEPNVCVEMSANGGDEPAVKDSEPVVSENSRSMEGETEPVVVSDASVACPTMDLDESGLKKTDEGLACSIEVGLEKVSLAVDDDEKSDEAKGEMDSAESESETSSSSASSSDSSSSEEEESDEDESDKEENKKEEKFEHMVVGKEDDLAGELEEGEIENLDEENGDDDIEDEDDDDDDDDDDDDDVNEMVAWSNDEDDDLGLQTKEPIRSKNELKELPPVPPVDVTLEPHHATLPVGVVLSVMSAQVIVEGMEKHSPLTEGSILWITEKRTPLGLVDEIFGPVKCPYYIVRFNSESEVPEGVCQGTPVSFVADFAQHILNIKELQKKGYDASGDNDEEIPDELEFSDDEKEAEYRRMQKLEKRGMMSDQKTGNTRNKKKKNRDPGRPTSSYSGEWTKNQGSSSLSSNRSDPQMGGPRPQMDGFPPNNAAWRPQSNQQNPYQLPPIPNQMGMQIPFMAMQNQNQMMFQPQFNGGQMPMPGGPGGLNFFPGQASAPWPAMVGQNCFNQQFGMGRGIQQQPLPNELSFNMFSQGLQMHPPQSQMHRPQSQMNPQFQMPPQFQPHQQSPMNPQYQMMHRPQSPANPQFQMQAQSDVRPLQSQIPQSPSDLQSPMEPQSQGFSSGQSSERGRGFHGRGRGRGRGRFGRGRGRGRQQSG
Protein: Serine protease inhibitor Kazal-type 1 (Cholecystokinin-releasing peptide) (Monitor peptide) (Pancreatic secretory trypsin inhibitor) (PSTI-I) (P09655)
Organism: Rattus norvegicus (Rat)
Function: Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:3597401}.
Interaction partners:
- Chymotrypsin-C
- Serine protease 1
- Serine peptidase inhibitor, Kazal type 4
Sequence:
MKVAIIFLLSALALLSLAGNPPAEVNGKTPNCPKQIMGCPRIYDPVCGTNGITYPSECSLCFENRKFGTSIHIQRRGTC
Protein: Probable serine/threonine-protein kinase yakA (EC 2.7.12.1) (Q54QV3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11410593}.
Interaction partners:
- DDB1- and CUL4-associated factor 7 homolog
- RNA binding protein
- Small GTPase
Sequence:
MGSTTQMSDYLVSTTTTSSASSMVTMTSQIENNSLNSNDNTNTTNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNNGGMVGVNHKTHKKTASIGGGKNRAILHDFTFSYFIPNQNRSEDNSNENELGLNNHNVQHQGPIIHLTKNLLHFYKKCNSNFNYISSLNPRRVLTHPSEPLSNDGYDNVNSDYIVYVNDIITNNESGQKYKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFLGLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEIIQNYGFKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFITGQPYNGPFIPDPSKKRHFTYSQPKQIPQHSMLNGNQILNQHQLFQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHNQFQQQQQQQQQQQQSSSQQHIQIQPLQLFSTPYTSTNNTPNLSSSNSGSSLNNLKKLNLPPFKQQQQQQFSTSQNSDSFNFPNESFSPRGIYIPSSASNIQQQQQPININNNQNGVGSQVSQLALGQSPSLFGTPTNIYPPYSSMYNNSPVATPNSLSFYGSSWGSDSSSISLNPSTPTQKQMFQQQQYSNNNNNNNNNNNNNSNNNNGNNTNNINSNNNNNNVNRRNRSKSDIPSDSFSSSEGMDPQFNLYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQYQQQFQTLQDLNIEGEKPPIYPNSPHRKRSHSGYLDQYANGYNSQQTNNTQQQQQQQQQQQQQQQQQQQQQQHPSFFSTRMHLDHFNGGSRYRSQSYGDQQFQQQQYKQQQKNLHHQQQQQQRFMQVGSPPTSHLSPPIPQSPLMMSQPLHQTYIPQQQQQQQQQQQQSQPTPFTPQMISQEPISPALMGDASSIWNPSPTEELLFTIDLPNQQNTPHLTPSNSSTNLLGKSASSPLKNSSGGAIPPTPTIPINMEEINNGFSKFHFNDQPSWNSNGNSPWMIQQQQQHQQGFNGNSESMYNDDLIGFSPYNNYSNDYRPQLFNKQSPPSSYNSNKSFYGGSGGGGNNNNNNNSRPTNQNFSNSLLPSQQQNVIFPQNSPPSSYNSSNSLSKSGGNTVKNNSNTGGRPRGDSMKQRFNSTNNLLSGGSYQYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYKKDTPSLMMSPPMNGLKTSSEIGIPSEEIRYQYQQQQLQQQFQQQQQQQQQQQIQQQLQQQQAPPQNRKQVVIGSYRET
Protein: Oxidoreductase (Q5A503)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Fth1p
- High-affinity iron permease
- Fth2p
- Ftr2p
Sequence:
MIFNQFILWLISIPLILASGTIHRFDWNVSYVMANPDGIHPRRMIGINNQWPNPTIRSKKNDRVIINLTNELPDKNVSLHFHGLFQRGYNDQDGPAFVTQCPISPGVTFTYDFNVTDQSGTYWYHSHMGSQYGDGLRGLFIIEYDNDDEYNKEFPYEYDEDVTLSVGDHYHLESPEIVKNFMTRFNPTGAEPIPQNGLFNETKNVTWQVNPDTTYLLRIVNMGLFTSHYVYIEDHTFTIVEVDGVVVEPYETDSLYVAVAQRYVVLMKTKKSADKNFRFVNVLDQDMLDFLPSDLQIVSTNWIVYDKSLELPPALPFNQFHKTIKSLVGFDDFDLRPLRKVNLLDEPDYTIQVNLTMEVLGDGVTYAMFNGKTFRPPKVPSLYTVLSTHGNTNLTTNELIYGTNTNSFVLQGDEVVEIILNNMDPGKHPFHLHGHNFQVISRFDTDDEDNQLVFDPTNETYTNYPEFPMVRDTVEVGPNGFIVLRFKADNPGVWFFHCHVDWHLEQGLAILLVEDPLELLSSNTTIPQNHIDACNAIGMPIKGNAAGNDIDLLDLYGENIQPNPLPAGFTNKGYLAITCCTLIAIYGLWSIYNYGMEDISKDNAEDVIEKLYKILDDYDK
Protein: Peptidoglycan hydrolase gp4 (Gene product 4) (Gp4) (Internal virion protein gp4) (Tail adapter protein gp4) (P26746)
Organism: Salmonella phage P22 (Bacteriophage P22)
Function: Tail protein located at the vertex occupied by the portal ring. 12 copies of gp4 form a structural ring at the bottom of the portal ring. Together with gp10 and gp26, gp4 is required for stabilization of the condensed DNA within the capsid; perhaps by plugging the hole through which the DNA enters. Probably functions as a head completion protein. Plays a role in ejection of the bacteriophage DNA into the host cell at the initiation of infection. Functions as an exolysin that catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycans.
Subcellular location: Virion {ECO:0000305}.
Interaction partners:
Sequence:
MQIKTKGDLVRAALRKLGVASDATLTDVEPQSMQDAVDDLEAMMAEWYQDGKGIITGYVFSDDENPPAEGDDHGLRSSAVSAVFHNLACRIAPDYALEATAKIIATAKYGKELLYKQTAISRAKRAPYPSRMPTGSGNSFANLNEWHYFPGEQNADSTTPHDEGNG
Protein: Ran-specific GTPase-activating protein 2 (Ran-binding protein 2) (RANBP2) (P40517)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.
Subcellular location: Nucleus {ECO:0000269|PubMed:9395535}.
Interaction partners:
- Exportin-1
- GTP-binding nuclear protein GSP1/CNR1
- SUMO-conjugating enzyme UBC9
- Nucleoporin NSP1
- Ran GTPase-activating protein 1
- Nuclear transport factor 2
- GTP-binding nuclear protein GSP2/CNR2
- E3 SUMO-protein ligase SIZ1
- Nucleoporin NUP133
- Nucleoporin NUP159
Sequence:
MSETNGGNAARENSEVKQTAVENPIDKLDGTPKRPREKDQDEQAEETSDKSEAPNKNDEEKKEEGKKDQEPSHKKIKVDDGKTVESGIVEDDKKEDKFVFGAASKFGTGFGVAKKDTKDGDATTSTESLPASDSKTKKPFAFGSGLSFGSGFNILKNKTENNSESEKKATDVDKDKVHSGSEQLANASEDTKDKPKPLKLQKQEVKSGEESEECIYQVNAKLYQLSNIKEGWKERGVGIIKINKSKDDVEKTRIVMRSRGILKVILNIQLVKGFTVQKGFTGSLQSEKFIRLLAVDDNGDPAQYAIKTGKKETTDELYNIIVKSVPK
Protein: Choline kinase A2 (EC 2.7.1.32) (Ethanolamine kinase) (EC 2.7.1.82) (Q22942)
Organism: Caenorhabditis elegans
Function: Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.
Interaction partners:
- ethanolamine-phosphate cytidylyltransferase
- ethanolamine-phosphate cytidylyltransferase
- Putative choline-phosphate cytidylyltransferase
- Phosphoethanolamine N-methyltransferase 2
- Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1
- Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 2
- Acetylcholinesterase 1
- Ethanolamine-phosphate phospho-lyase homolog 1
- Carboxylic ester hydrolase
- Choline O-acetyltransferase
Sequence:
MSSRKVSRAHYDEDELASAANMSLVAEGHFRGMKELLSTMDLDTDANTIPELKERAHMLCARFLGGAWKTVPLEHLRISRIKGGMSNMLFLCRLSEVYPPIRNEPNKVLLRVYFNPETESHLVAESVIFTLLSERHLGPKLYGIFSGGRLEEYIPSRPLSCHEISLAHMSTKIAKRVAKVHQLEVPIWKEPDYLCEALQRWLKQLTGTVDAEHRFDLPEECGVSSVNCLDLARELEFLRAHISLSKSPVTFCHNDLQEGNILLPKASSGNIRMPSLSDETQALGNSLSAFNPADPRLVLIDFEYASYNYRAFDFANHFIEWTIDYDIDEAPFYKIQTENFPENDQMLEFFLNYLREQGNTRENELYKKSEDLVQETLPFVPVSHFFWGVWGLLQVELSPVGFGFADYGRDRLSLYFKHKQLLKNLASHQ
Protein: Uncharacterized protein (Q54BY9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Epidermal growth factor receptor substrate 15 homolog
- EF-hand domain-containing protein
- AP-1 complex subunit beta
- AP-4 complex subunit beta
- phosphoinositide 5-phosphatase
- SH3 and F-BAR domain-containing protein DDB_G0274695
- AP-2 complex subunit mu
- Rho-related protein rac1A
- NECAP PHear domain-containing protein
- AP-2 complex subunit sigma
Sequence:
MIFLFKTSNKYFYLLGVGGSCFLGFVFLYFLKKSYNNKNNKFIESDNNNKNNFEKEEKEMSQQLIEIRKKINDYSKLKYPTKQGILFKKSRYLKEWRNRFFVIEEDILYYFDIEKGNNSNKPIGTPLGIFNLLNCSFTLITNEKRSPLVFKIQEENGTNKDYKNCLISCESAEEFNQWFQLLPQIKQTMDRKKDLVIKLQALSRKKLQQKKYQQLKESALTIQRFYHLYEGERKLARFIFNVIKVQSYARCFIDRMRYKKIKEEIMVIQSHFQVIKAKNRLEKEFMRRRIAQELLSTEKSYVYNLKLIIDIFIRPLINFNSIEQRVLSVSEISGVFGNWERLYKINSDLLVLIQCKLDNWSIDQTIGDLFIENTDSLFEYTPYVTNYDHSRKLLAKLTSGNTNFRNFLDAAQRDKRSKYLDISSFLIQPIQRLPRYELLLRDLLKSTSTLHKDHKYLSKGIVKIKEITMYVNDQQKERENLSQVIQIQKELIMDNIKLSFSSATRLIREGEIKVSKKKTWNYMYLFNSQLVIIQKKDDKKLVKEVIQLEQLGIRDDNSSSSNTITNDSGTDLLNNSSNNLLLLSSTISSPDLSSSGTNAINTSSQALPIGTIGNKFKLIISSKTEISLYFDTPEEKNNWFADIAITLNRLETQKKNFEKSINLQTIN
Protein: Protein embryonic gonad (Nuclear receptor subfamily 0 group A member 3) (Protein eagle) (Protein spready) (P15370)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a critical role in development of the progeny of eagle-positive neuroblasts.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Smrter, isoform G
Sequence:
MNQLCKVCGEPAAGFHFGAFTCEGCKSFFGRTYNNIAAIAGCKHNGDCVINKKNRTACKACRLRKCLLVGMSKSGSRYGRRSNWFKIHCLLQEQQTTSGLGGGSSVGSGSGGGVSSASLEQLARLQQASNQARQTYQDKTNPCIKSATATTSPRIEGAAVGTGIGGGASPSFLQAAKLHHQRQLKLDSRLSNTPSDSGASSAGDPNEDGVTSVLGGQIATPSSTNATSLPKLDLRHPNFPATSEPDADMQRQRHQELLEIFRSHSEPLYSSFAPFSHLPPVLLAAGVPQLPIFKDQFKAELLFPTTSSPELEEPIDLSFRSRADPASPMAHNSNSPSLSEPAAASHCLGESTNFVRKSTPLDLTLVRSQTLTG
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (Q9N5S9)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MEAIIEDEVTSRFEAEQLVSWNMLTRTSIKFYQFVNWKLSALWILGFMFRYCVMLPLRFTVFCIGLVFLISSTALIGLVPIGNWKKALNHKCMLICYRILSRSLTAVVYFHDEHYKAQAQGICVANHTSPIDALILSIDNVYALIGQKHEGLLGIVQRALSRASSHIWFERSEAKDRLVVAQKLKEHCTNPDKLPILIFPEGTCINNTSVMMFKKGSFEIGTTIYPIAMKYDSRFGDAFWNSSEQSWCGYIMRMMTSWAIICNVWYLPPMTRRDGEDAVDFANRVKKEIANKGGLVDLEWDGGLKRAKVPPKMVAKQQERYANRLSRYTSVSEVVKDEDVDVTSDSSSDLVDKPVSGYNSLEDLPEDVFIDEEEDETIDAHDENENDDPAGESNILPNKPLSDTVSLVKT
Protein: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (7,8-diaminopelargonic acid synthase) (DAPAS) (Diaminopelargonic acid synthase) (P9WQ81)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor. Can also use sinefungin but not S-adenosylhomocysteine as substrate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00834}.
Interaction partners:
- Biotin synthase
- Dethiobiotin synthetase BioD
- 8-amino-7-oxononanoate synthase 1
- Putative 8-amino-7-oxononanoate synthase 2
- Conserved protein
- Glutamine-dependent NAD
- Uncharacterized methyltransferase Rv0089
- Pantothenate synthetase
- Biotin--[acetyl-CoA-carboxylase] ligase
- Probable hypothetical membrane protein
Sequence:
MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP
Protein: Probable pectin methyltransferase QUA3 (EC 2.1.1.-) (Protein QUASIMODO 3) (Q93W95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase) which mediates the methylesterification of the pectin homogalacturonan (HG) and thus regulates cell wall biosynthesis, at least in suspension-cultured cells.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21725030}; Single-pass type II membrane protein {ECO:0000269|PubMed:21725030}.
Interaction partners:
- Probable galacturonosyltransferase 7
- Leucine-rich repeat
- Leucine-rich repeat
- Probable pectin methylesterase CGR3
- Probable pectin methylesterase CGR2
- Polygalacturonate 4-alpha-galacturonosyltransferase
- Leucine-rich repeat
- Leucine-rich repeat
- Vacuolar-sorting receptor 5
- Transmembrane 9 superfamily member 9
Sequence:
MGHVNLPASKRGNPRQWRLLDIVTAAFFGIVLLFFILLFTPLGDSMAASGRQTLLLSTASDPRQRQRLVTLVEAGQHLQPIEYCPAEAVAHMPCEDPRRNSQLSREMNFYRERHCPLPEETPLCLIPPPSGYKIPVPWPESLHKIWHANMPYNKIADRKGHQGWMKREGEYFTFPGGGTMFPGGAGQYIEKLAQYIPLNGGTLRTALDMGCGVASFGGTLLSQGILALSFAPRDSHKSQIQFALERGVPAFVAMLGTRRLPFPAYSFDLMHCSRCLIPFTAYNATYFIEVDRLLRPGGYLVISGPPVQWPKQDKEWADLQAVARALCYELIAVDGNTVIWKKPVGDSCLPSQNEFGLELCDESVPPSDAWYFKLKRCVTRPSSVKGEHALGTISKWPERLTKVPSRAIVMKNGLDVFEADARRWARRVAYYRDSLNLKLKSPTVRNVMDMNAFFGGFAATLASDPVWVMNVIPARKPLTLDVIYDRGLIGVYHDWCEPFSTYPRTYDFIHVSGIESLIKRQDSSKSRCSLVDLMVEMDRILRPEGKVVIRDSPEVLDKVARMAHAVRWSSSIHEKEPESHGREKILIATKSLWKLPSNSH
Protein: D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39) (P84850)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15070399}.
Interaction partners:
- L-2-hydroxyglutarate dehydrogenase, mitochondrial
- DNA methyltransferase 1-associated protein 1
- Chromatin modification-related protein MEAF6
- YEATS domain containing 4
Sequence:
MVLHLVPRWSASLFRASPRWKKTYSQRASAQLKWLGCPRSVYSPLACRAYSKVSGSPEVMLTPERYPVQRLPFSTVSEEDLAAFECIIPGRVITDPEQLQTCNVDWLRTVRGCSKVLLRPQTSEEVSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQAGCVLEELSRYVQERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLRGTVLGLEVVLADGTILNCLTSLRKDNTGYDLKQMFIGSEGTLGVITAVSIVCPPRPKAVNVAFLGCPGFTEVLQTFRTCKGQLGEILSAFEFMDAECMQLVGQHLHLTNPVQESPFYVLVETSGSSAGHDAEKLTNVLEQVLNSGLVIDGTMATDQRKVQMLWALRERITEALSRDGYVFKYDLSLPVERLYDLVIDLRTRLGPRAKHVVGYGHLGDGNLHLNVTAEAFSQELLGALEPYVYAWTAEQRGSVSAEHGLGFKKKNVLGYSKPPVAVKLMQQLKAMLDPKGILNPYKTLPARA