wanglab/gogpt-training-data huggingface dataset:
Protein: At2g29210/F16P2.41 (Splicing factor PWI domain-containing protein) (Q8L7W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Regulator of nonsense transcripts UPF3
- RNA-binding motif protein 25
- Regulator of nonsense transcripts UPF2
- Pre-mRNA-splicing factor 38
- Peptidyl-prolyl cis-trans isomerase CYP18-2
- Peptidyl-prolyl cis-trans isomerase CYP65
- Serine/arginine-rich splicing factor SC35
- Pre-mRNA-processing protein 40C
- Protein EARLY FLOWERING 5
- G patch domain-containing protein TGH
Sequence:
MSGGFFRGTSAEQDTRFSNKQAKLMKSQKFAPELENLVDITKVKMDVMKPWIATRVTELLGIEDEVLINFIYGLLDGKVVNGKEIQITLTGFMEKNTGKFMKELWTLLLSAQNNPSGVPQQFLDARAAETKKKQEEANEIMKKREGDKKNIEHDILRKIDSGVEHKETNGMDAKPSRDRPEDGRRADEKNGVKERRRDLIPPRRGDASRSPLRGSRSRSISKTNSGSKSYSGERKSRSTSQSSDASISPRKRRLSNSRRRSRSRSVRRSLSPRRRRIHSPFRSRSRSPIRRHRRPTHEGRRQSPAPSRRRRSPSPPARRRRSPSPPARRRRSPSPPARRHRSPTPPARQRRSPSPPARRHRSPPPARRRRSPSPPARRRRSPSPPARRRRSPSPLYRRNRSPSPLYRRNRSRSPLAKRGRSDSPGRSPSPVARLRDPTGARLPSPSIEQRLPSPPVAQRLPSPPPRRAGLPSPPPAQRLPSPPPRRAGLPSPMRIGGSHAANHLESPSPSSLSPPGRKKVLPSPPVRRRRSLTPDEERVSLSQGGRHTSPSHIKQDGSMSPVRGRGKSSPSSRHQKARSPVRRRSPTPVNRRSRRSSSASRSPDRRRRRSPSSSRSPSRSRSPPVLHRSPSPRGRKHQRERRSPGRLSEEQDRVQNSKLLKRTSVPDTDKRKQLPEKLLEVGRVEHYKEQERKSDKLSEKRSVHRHHGSQMSPVENSEGRSRPVSSKVKDSEQVEKEDNSDLDANLSCDSKDTIRHQIKDKNRRKNKRSSREEVSSDDNGSSDSDVDDRKEAKRRRKEEKKTRKEEKKRRREERHRKREERRGGKEKHKKQELSDTSEGEVEARPKIKKGEESDPKRLEIELRNKALESLKAKKGISH
Protein: dTDP-fucopyranose mutase (EC 5.4.99.59) (dTDP-alpha-D-fucopyranose mutase) (Q6E7F1)
Organism: Escherichia coli
Function: Catalyzes the conversion of dTDP-alpha-D-fucopyranose to dTDP-alpha-D-fucofuranose. This is a step in the biosynthesis of D-fucofuranose, a component of E.coli O52 O antigen.
Interaction partners:
Sequence:
MNKVLIIGSGFSGATIARLLAEENIKVKIIDDRKHIGGNCYDERDEKTGINVHVYGPHIFHTDNEDVWNFVNKYGTFQPYTTRLKANAKGQIYSLPVNLHTINQYYKTALSPTEARKLIASKGDQTINDPQSFEEQALKFVGEDLYKTFFYGYPKKQWGMEPKEIPASVLKRLPVRFNYDDNYFFHKFQGIPRDGYTPLFQNLLNHPNIEFELGKKVNRATVEELITSEQYGHVFFSGAIDHFYDYEFGMLQYRTLDFEKFYSEDDDYQGCVVMSYCDEDVPYTRVTEHKYFTPWEEHKGSVLYKEFSRSCDKEDIPYYPVRLVSGNSIWNKYEQKAKEETNITFIGRLATYRYLDMDVCIKEAIECAQLYIKNNKE
Protein: Adipocyte fatty acid-binding protein (Fabp11b protein) (Fatty acid binding protein 11b) (Fatty acid binding protein 4b) (Q503X5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Fatty acid binding protein 1-B.1
- Fatty acid binding protein 1-A, liver
- Gastrotropin
- Fatty acid-binding protein 2, intestinal
- Brain-type fatty acid-binding protein
- Brain-type fatty acid-binding protein b
- Fatty acid-binding protein 3, muscle and heart
- Fatty acid binding protein 11a
- Fatty acid-binding protein 10b, liver basic
- Fatty acid binding protein 1-B.1
Sequence:
MVEQYVGKWKMTSSDNFDEYMKAVGASFASRQMANLAKPSLLIAVDEQGVITMKAVTTFKTLEIKFKLDEEFDETTADDRKVKTTMSLADGKLIQKQTWEGKTTIIEREIQDTKMIAKCTMDDVVAIRTYEKDA
Protein: ATP synthase subunit c, chloroplastic (ATP synthase F(0) sector subunit c) (ATPase subunit III) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein) (P0C301)
Organism: Oryza sativa subsp. japonica (Rice)
Function: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01396}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01396}.
Interaction partners:
- ATP synthase subunit alpha
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit b, chloroplastic
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit a, chloroplastic
- F-ATPase gamma subunit
- Probable V-type proton ATPase subunit d
- Os02g0750100 protein
- Os01g0610100 protein
- ATP synthase B chain, chloroplast, putative, expressed
Sequence:
MNPLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
Protein: Probable ATP-dependent permease (P25371)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit delta, mitochondrial
- Intermembrane lipid transfer protein VPS13
- Protein arginine N-methyltransferase SFM1
Sequence:
MGSHRRYLYYSILSFLLLSCSVVLAKQDKTPFFEGTSSKNSRLTAQDKGNDTCPPCFNCMLPIFECKQFSECNSYTGRCECIEGFAGDDCSLPLCGGLSPDESGNKDRPIRAQNDTCHCDNGWGGINCDVCQEDFVCDAFMPDPSIKGTCYKNGMIVDKVFSGCNVTNEKILQILNGKIPQITFACDKPNQECNFQFWIDQLESFYCGLSDCAFEYDLEQNTSHYKCNDVQCKCVPDTVLCGAKGSIDISDFLTETIKGPGDFSCDLETRQCKFSEPSMNDLILTVFGDPYITLKCESGECVHYSEIPGYKSPSKDPTVSWQGKLVLALTAVMVLALFTFATFYISKSPLFRNGLGSSKSPIRLPDEDAVNNFLQNEDDTLATLSFENITYSVPSINSDGVEETVLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTGHVSGSIKVNGISMDRKSFSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKALSFEAKKARVYKVLEELRIIDIKDRIIGNEFDRGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVYSGNAKKVSEFLRNEGYICPDNYNIADYLIDITFEAGPQGKRRRIRNISDLEAGTDTNDIDNTIHQTTFTSSDGTTQREWAHLAAHRDEIRSLLRDEEDVEGTDGRRGATEIDLNTKLLHDKYKDSVYYAELSQEIEEVLSEGDEESNVLNGDLPTGQQSAGFLQQLSILNSRSFKNMYRNPKLLLGNYLLTILLSLFLGTLYYNVSNDISGFQNRMGLFFFILTYFGFVTFTGLSSFALERIIFIKERSNNYYSPLAYYISKIMSEVVPLRVVPPILLSLIVYPMTGLNMKDNAFFKCIGILILFNLGISLEILTIGIIFEDLNNSIILSVLVLLGSLLFSGLFINTKNITNVAFKYLKNFSVFYYAYESLLINEVKTLMLKERKYGLNIEVPGATILSTFGFVVQNLVFDIKILALFNVVFLIMGYLALKWIVVEQK
Protein: Glyceraldehyde-3-phosphate dehydrogenase 2 (GAPDH 2) (EC 1.2.1.12) (O43026)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Probable transketolase
- Transaldolase
- Glucose-6-phosphate isomerase
- Probable phosphoketolase
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Enolase 1-1
- Glucose-6-phosphate 1-dehydrogenase gcd1
Sequence:
MAIPKVGINGFGRIGRIVLRNAILTGKIQVVAVNDPFIDLDYMAYMFKYDSTHGRFEGSVETKGGKLVIDGHSIDVHNERDPANIKWSASGAEYVIESTGVFTTKETASAHLKGGAKRVIISAPSKDAPMFVVGVNLEKFNPSEKVISNASCTTNCLAPLAKVINDTFGIEEGLMTTVHATTATQKTVDGPSKKDWRGGRGASANIIPSSTGAAKAVGKVIPALNGKLTGMAFRVPTPDVSVVDLTVKLAKPTNYEDIKAAIKAASEGPMKGVLGYTEDSVVSTDFCGDNHSSIFDASAGIQLSPQFVKLVSWYDNEWGYSHRVVDLVAYTASKD
Protein: poly(A)-specific ribonuclease (EC 3.1.13.4) (X2JCC3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- poly
- Protein associated with topo II related - 1, isoform A
- CCR4-NOT transcription complex subunit 9
- Regulator of gene activity
- Not1, isoform H
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 4
- CCR4-NOT transcription complex subunit 10
- ATP-dependent RNA helicase me31b
- CCR4-NOT transcription complex subunit 11
Sequence:
MKWTMPSAISGAPHAHIPSNEECGIRDVWKQNLEEEFRTIRKVVQKYHYVAMDTEFPGVVARPVGEFRSTADYHYQLLRCNVDLLRIIQLGLTFMDDDGKTPPGYSTWQFNFKFNLSEDMYAQDSIDLLQNSGIQFKKHEEDGIDPIDFAELLMSSGIVLVENIKWLCFHSGYDFGYLLKLLTDQNLPPDESEFFDLLHIYFPNIFDIKYLMKSCKNLKGGLQEVADQLELRRVGPQHQAGSDALLTGMAFFKMREVQHTNDFHITPVAHDVLFRYLLEHTMNLKPTISCIHLLSRPAYNGGPAPDESAIISSGNGTGNTNSTEQFTSSAYMVTPPNTPGMAKSDAASLSNRHTSISNSFG
Protein: Homeostatic iron regulator (F8W7W8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSSF
Protein: Conserved protein (P96817)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable conserved integral membrane protein
- Uncharacterized protein Rv3067
- Possible oxidoreductase
- SnoaL-like domain-containing protein
Sequence:
MSNRIVLEPSADHPITIEPTNRRVQVRVNGEVVADTAAALCLQEASYPAVQYIPLADVVQDRLIRTETSTYCPFKGEASYYSVTTDAGDIVDDVMWTYENPYPAVAAIAGHVACYPDKAEISIFPG
Protein: Protein LOL5 (OsLOL2) (Protein LSD ONE LIKE 5) (OsLOL5) (Putative zinc finger LOL5) (Q704V3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in plant growth and disease resistance.
Subcellular location: Nucleus {ECO:0000269|PubMed:17404758}.
Interaction partners:
- Rac-like GTP-binding protein 5
- Rac-like GTP-binding protein 3
- Rac-like GTP-binding protein 7
- Rac-like GTP-binding protein 2
- Rac-like GTP-binding protein 1
- Os01g0540300 protein
- Os11g0303400 protein
- Rac-like GTP-binding protein 6
- Rac-like GTP-binding protein 4
- Dol-P-Glc:Glc
Sequence:
MSQLPLASQATTTDLVSTTAMQPQSEGIVDESLQPQHPPSSTAHDSPCLQDSVPLVPPPPSPYLNKEVGQMVCGSCRILLAYFRGAGYVHCTCCQTMNYVLEAHEVGKVHCGHCATLLMYPFGAPAVKCSLCLFVTEIGERNVRRRLSIEQPTRTNSSGLAEA
Protein: Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134) (P43489)
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 4
- Tumor necrosis factor ligand superfamily member 9
- CD70 antigen
- T-lymphocyte activation antigen CD80
- ICOS ligand
- T-lymphocyte activation antigen CD86
- Ig-like domain-containing protein
- Tumor necrosis factor receptor superfamily member 18
- Tumor necrosis factor receptor superfamily member 5
- Tumor necrosis factor receptor superfamily member 8
Sequence:
MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI
Protein: Sarcolamban B (C0HJH3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction.
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:23970561}; Single-pass membrane protein {ECO:0000269|PubMed:23970561}. Note=Colocalizes with SERCA at the sarcoplasmic reticulum and the diad, a structure composed of a single t-tubule paired with a terminal cisterna of the sarcoplasmic reticulum. {ECO:0000269|PubMed:23970561}.
Interaction partners:
- Sarcolamban A
Sequence:
MNEAKSLFTTFLILAFLLFLLYAFYEAAF
Protein: Glycoprotein endo-alpha-1,2-mannosidase (EC 3.2.1.130) (X6R7A2)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MAKFRRRTCIILALFILFIFSLMMGLKMLRPNTATFGAPFGLDLLPELHQRTIHLGKNFDFQKSDRINSETNTKNLKSVEITMKPSKASELNLDELPPLNNYLHVFYYSWYGNPQFDGKYIHWNHPVLEHWDPRIAKNYPQGRHNPPDDIGSSFYPELGSYSSRDPSVIETHMRQMRSASIGNYCIYIYVCLCLYICI
Protein: AP2-like ethylene-responsive transcription factor At2g41710 (Q8GWK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ethylene-responsive transcription factor-like protein At4g13040
- Protein TIME FOR COFFEE
- TIC-like protein
Sequence:
MASVSSSDQGPKTEAGCSGGGGGESSETVAASDQMLLYRGFKKAKKERGCTAKERISKMPPCTAGKRSSIYRGVTRHRWTGRYEAHLWDKSTWNQNQNKKGKQVYLGAYDDEEAAARAYDLAALKYWGPGTLINFPVTDYTRDLEEMQNLSREEYLASLRRYPFGRKSSGFSRGIAKYRGLQSRWDASASRMPGPEYFSNIHYGAGDDRGTEGDFLGSFCLERKIDLTGYIKWWGANKNRQPESSSKASEDANVEDAGTELKTLEHTSHATEPYKAPNLGVLCGTQRKEKEISSPSSSSALSILSQSPAFKSLEEKVLKIQESCNNENDENANRNIINMEKNNGKAIEKPVVSHGVALGGAAALSLQKSMYPLTSLLTAPLLTNYNTLDPLADPILWTPFLPSGSSLTSEVTKTETSCSTYSYLPQEK
Protein: Homeobox-containing protein 1 (Q9TYT0)
Organism: Caenorhabditis elegans
Function: Transcriptional repressor which maintains cell fate asymmetry of AWC neurons in adults by repressing the expression of multiple AWC (OFF) genes, including srsx-3 in the AWC (ON) neuron.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000305|PubMed:20713521}.
Interaction partners:
- Transcription factor nsy-7
- G-protein coupled receptors family 1 profile domain-containing protein
Sequence:
MLFTIEQLELIKKLQHTGMSSDQLLKAFGELEVPEQLQNNNTIAAALYSPLLVQHLTTPKSETPVKLTVQTVPTPVKSEPQSSNCSSPFEHPICSNAPRPIRSQRTPMKEITTLDDPNELEEFMKQGEEACILDMKTFITQYSLRQTTVAMMTGVSQPYISKLLNGNHRELSLRCRKNIYCWYLNCRRHPNKLAAFLADPTTRLETNGDGELIPQRRERYVFRPILIRMLESFFTQTPFPDLPRRVEIANACNHVLKMDKKGVGLMPKEVVSPQVVSNWFANKRKELRRRSAEASAASTSSASSSASSTANHDSVSVSSMSPRDEETSSRNTTPETAISPSPAVSTFEVSRPSAIISATSSTTSPISIPATIIPSVSPSALELFAMAQQLGVQLPVPFPTLPTHFFPFQMAPFYGNPASILKSE
Protein: DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) (Q6UX65)
Organism: Homo sapiens (Human)
Function: Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:19556885, ECO:0000269|PubMed:19895784}; Multi-pass membrane protein {ECO:0000269|PubMed:19556885, ECO:0000269|PubMed:19895784}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9CR48}. Apical cell membrane {ECO:0000250|UniProtKB:Q9CR48}. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250|UniProtKB:Q9CR48}.
Interaction partners:
- Beclin-1
Sequence:
MWWFQQGLSFLPSALVIWTSAAFIFSYITAVTLHHIDPALPYISDTGTVAPEKCLFGAMLNIAAVLCIATIYVRYKQVHALSPEENVIIKLNKAGLVLGILSCLGLSIVANFQKTTLFAAHVSGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSALSMLTCSSVLHSGNFGTDLEQKLHWNPEDKGYVLHMITTAAEWSMSFSFFGFFLTYIRDFQKISLRVEANLHGLTLYDTAPCPINNERTRLLSRDI
Protein: Actin-depolymerizing factor 8 (ADF-8) (AtADF8) (Q570Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ZSK3}.
Interaction partners:
- Profilin-1
- Profilin-5
- Profilin-2
- Profilin-4
- Profilin-3
- Cyclase-associated protein 1
- Villin-5
- Villin-1
- Protein phosphatase EYA
- Scar-like domain-containing protein WAVE 5
Sequence:
MANSASGMHVNDECKIKFLELKAKRTYRFIVFKIDEKAQQVQIEKLGNPEETYDDFTSSIPDDECRYAVYDFDFTTEDNCQKSKIFFIAWSPDTSRVRSKMLYASSKDRFKREMEGIQVELQATDPSEMSLDIIKGRLNL
Protein: LHFPL tetraspan subfamily member 4 protein (GABAA receptor regulatory Lhfpl4) (Lipoma HMGIC fusion partner-like 4 protein) (Q5U4E0)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.
Subcellular location: Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TSY2}. Postsynaptic cell membrane {ECO:0000269|PubMed:28978485, ECO:0000269|PubMed:29742426}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to inhibitory postsynaptic sites (PubMed:28978485, PubMed:29742426). Colocalizes with GPHN, GABRG2 and NLGN2 at inhibitory postsynaptic sites (By similarity) (PubMed:29742426). {ECO:0000250|UniProtKB:Q7TSY2, ECO:0000269|PubMed:28978485, ECO:0000269|PubMed:29742426}.
Interaction partners:
- Neuroligin-2
- Gephyrin
Sequence:
MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKQENKDFVGTTVSSVLRPGGDVSGWGVLPCPVAHTQGP
Protein: chitin synthase (EC 2.4.1.16) (Q8MQN8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYGDAFGPHKIIVYELPAGLGGVLPDTLESANIDTVDVDAAYNTVVYVLLLQIFGAYLCYIFGKFACKILIQGFSYAFPVSLTVPLSVTFLIAACGIRIDDPCFFHDTIPDYLFFTSPSNFRFNNFVTEQMAWAWILWLLSQTWIALHIWTPKCERLATTEKLFVQPMYSSLLIDQSMALNRRRDDQADVKTEDLSEIEKEKGDEYYETISVHTDRSSAPNKPSIKSSDNITRIYSCATMWHETKDEMIEFLKSIMRMDEDQCARRVAQKYLRVLDPDYYEFETHIFFDDAFEISDHSDDDIQCNRFVKLLIATMDEAASEIHQTTIRLRPPKKYPTPYGGRLVWTLPGKTKFITHLKDKDRIRHRKRWSQVMYMYYLLGHRLMELPISVDRKDAIAENTYLLTLDGDIDFKPNAVTLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQLFEYAIGHWLQKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEARHYVQYDQGEDRWLCTLLLQRGYRVEYSAASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLADAKRTIKINDNISLLYIFYQMMLMGGTILGPGTIFLMLVGAFVAAFRIDNWTSFHYNIVPILAFMFICFTCKSNIQLFVAQVLSTAYALIMMAVIVGTALQLGEDGIGSPSAIFLISMVGSFFIAACLHPQEFWCITCGLIYLLSIPSMYLLLILYSIINLNVVSWGTREVVAKKTKKELEAEKKAAEEAKKRVKQKSMLSFLQSGIGDNGDEEGSVEFSLAGLFRCIFCTHGKTSDEKQQLTSIAESLDTIKHRMDTIESAVDPHGHHASRHGRRRTTSSGSKDHHLLTSVAEKSGDESDESDSDTSAEPKQERDFLTNPYWIEDPDVRKGEVDFLSSTEIQFWKDLIDQYLYPIDNDPVEQARIAKDLKELRDSSVFAFFMINALFVLIVFLLQLNKDNIHVKWPFGVRTNITYDESTQEVHISKEYLQLEPIGLVFVFFFALILIIQFTAMLFHRFGTISHILASTELNFCKKKSEDLTQDQLIDKHAVEIVKNLQRLQGIDGDYDNDSGSGPDRIARRKTIQNLEKARQPRRQIGTLDVAFKKRF
Protein: Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling) (O15492)
Organism: Homo sapiens (Human)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P97428}; Lipid-anchor {ECO:0000250|UniProtKB:P97428}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Glycerophosphodiester phosphodiesterase 1
- Guanine nucleotide-binding protein G
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling protein-like
Sequence:
MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT
Protein: START domain-containing protein (Q57UU2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPRTFYRRTATLCVSAAVATFTRRSSVWLQELSSPVSGSEQLLACMDFLDAHKGQWRIESTSFPPPAKLESVGNEPGLQVLRLSTTYTAVSNGGRGVPVLRLIGYLPGVAPEEVHRHMTDLKLRRQWDHNYTMFCRWDDGTRKFIDPLGLIRRPMEHVTRKTPVCEGDRCLLLPDVTSCVVDSGWFAHRVGNSLLEKFGIAERLFIYQRRSLCYTKQGGADANPLRMYDVLYSGDGEMLNHARTQSERFAEWMRSCSGGRKVSLVSMNYQHVLIVPISDVTAQVWKQPDRLSFGGSMVSEENTKAVYNLFMETTSHFKETRKLDGTLVVMTSANDASIPSHIPMWLQRKLTSVFSTYVYQQLLEAILSKRRDLNSEGKF
Protein: Septin-7 (CDC10 protein homolog) (Q9WVC0)
Organism: Rattus norvegicus (Rat)
Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15485874}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q16181}. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase (By similarity). Associated with actin stress fibers. According to PubMed:15485874, also found in the nucleus. Found in the sperm annulus (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q16181}.
Interaction partners:
- Septin-9
- Septin-11
- Septin
- Septin-2
- Neuronal-specific septin-3
- Septin-5
- Septin-8
- Mitogen-activated protein kinase 6
- Septin
- Septin-12
Sequence:
MSVSARSAAAEERSVNCSTMAQPKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQGHKIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKNKKKGKIF
Protein: Type-1 angiotensin II receptor A (Angiotensin II type-1 receptor A) (AT1 receptor A) (P25095)
Organism: Rattus norvegicus (Rat)
Function: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30556}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30556}.
Interaction partners:
- Angiotensinogen
- Guanine nucleotide-binding protein G
- Angiotensin-converting enzyme 2
- Guanine nucleotide-binding protein subunit alpha-12
- Plasminogen activator inhibitor 1
- Type-2 angiotensin II receptor
- Beta-arrestin-2
- Angiotensin-converting enzyme
- Type-1 angiotensin II receptor B
- Prothrombin
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE