wanglab/gogpt-training-data huggingface dataset:
Protein: Collagen alpha-1(IX) chain (P20850)
Organism: Rattus norvegicus (Rat)
Function: Structural component of hyaline cartilage and vitreous of the eye.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Collagen type IX alpha 3 chain
- Collagen type IX alpha 2 chain
- CD44 antigen
- Glycoprotein VI
- Collagen alpha-1
- Matrilin-3
- Integrin alpha-2
- Integrin subunit alpha 3
- Collagen alpha-1
- Integrin alpha-1
Sequence:
PGQLGNSGKPGQQGPPGEVGPRGPRGLPGSRGPVGPEGSPGIPGKLGPLGSPGLPGLPGPPGLPGMKGDRGVFGEPGPKGEQGASGEEGEAGVRGDLGDMGQPGPKGSVGNPGEPGLRGPEGIRGLPGVEGPRGPPGPRGVQGEQGATGLPGIQGPPGRAPTDQHIKQVCMRVVQEHFAEMAASLKRPDTGASGLPGRPGPPGPPGPPGENGFPGQMGIRGLPGIKGPPGALGLRGPKGDLGEKGERGPPGRGPKGLPGAIGLPGDPGPASYGKNGRDGEQGPPGVAGIPGVPGPPGPPGPPGFCEPASCTLQAGQRAFSKGPDK
Protein: glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39) (Q9ZUP5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT4g33380/F17M5_140
- Actin-related protein 4
Sequence:
MNLLAFVVGFGIMGIVMVDGLGVNWGTMATHKLPPKKVVQMLKDNNINKVKLFDADETTMSALSGSGLEVMVAIPNDQLKVMGSYDRAKDWVHKNVTRYNFNGGVNITFVAVGNEPFLKSYNGSFINLTFPALQNIQNALNEAGLGSSVKATVPLNADVYDSPSSNPVPSAGRFRPDIIGQMTQIVDFLGNNSAPITINIYPFLSLYGNDDFPLNYAFFDGAKPVDDNGIAYTNVFDANFDTLVSALKAVGHGDMPIIVGEVGWPTEGDKHANSGSAYRFYNGLLPRLGENRGTPLRPTYIEVYLFGLLDEDAKSIAPGEFERHWGIFKFDGQPKFPIDLSGQGQNKLLIGAENVTYQPKKWCMFNTEAKDLTKLAANIDYACTFSDCTALGYGSSCNTLDANGNASYAFNMYFQVKNQDEDACIFQGLATITTKNISQGQCNFPIQIVASTASSFSSSLVLLIAGVWFLLSGVMFEV
Protein: Protocadherin-8 (Arcadlin) (Paraxial protocadherin) (Q7TSK3)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Presynaptic cell membrane. Postsynaptic cell membrane {ECO:0000250}. Note=Expressed in neuronal cell bodies and dendrites. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.
Interaction partners:
- Predicted gene, 38666
Sequence:
MSPAKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGPSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVNDNAPEISITPLAAPGAPATSPFAAAAAAAALGGADAASSTGSGTQEAGITSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDENDNAPIFTKPVYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVLDQNDHSPILVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPGRVFKALLVISDGGRPPLTTTATVSFVVTAGGGSAVPASSGSPEHSRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPDETARGTGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNVHPPPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGSRYVSPKKGINENV
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (A1KFH2)
Organism: Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Function: Acts as a chaperone.
Subcellular location: Cytoplasm {ECO:0000305}. Extracellular vesicle, bacterial extracellular vesicle {ECO:0000269|PubMed:21364279}. Note=Also present in extracytoplasmic vesicles (PubMed:21364279). Although thought of as a cytoplasmic chaperone this protein is routinely found extracellularly in the absence of cell lysis (By similarity) (PubMed:21364279). {ECO:0000250|UniProtKB:P9WMJ9, ECO:0000269|PubMed:21364279}.
Interaction partners:
Sequence:
MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK
Protein: Photosystem II CP43 reaction center protein (PSII 43 kDa protein) (Protein CP-43) (Q6ENJ0)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01496}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01496}.
Interaction partners:
- Photosystem II D2 protein
- photosystem II
- Cytochrome b559 subunit alpha
- Photosystem II CP47 reaction center protein
- Photosystem II protein D1
- Photosystem II protein D1
- Uncharacterized protein
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein H
- Photosystem II reaction center protein Z
Sequence:
MKILYSLRRFYHVETLFNGTFVLAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVLDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVLKALYFGGIYDTWAPGGGDVRKITNLTLSPGVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGFICVFGGIWHILTKPFAWARRAFVWSGEAYLSYSLGALSVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFFFVGHLWHAGRARAAAAGFEKGIDRDLEPVLYMTPLN
Protein: RRM domain-containing protein (Q9CT37)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
SLSKRLALLLTGQAASPQLCPGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPP
Protein: Protein TIFY 4B (Protein PEAPOD 2) (Q8GY55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the arrest of dispersed meristematic cells during lamina development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Fanconi anemia group I-like protein
- AT5G65740 protein
- AFP homolog 2
- Histone acetyltransferase
- Fanconi-associated nuclease 1 homolog
- Uncharacterized protein At3g24150
- GATA transcription factor 28
- Protein TIFY 8
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
Sequence:
MDVGVTTAKSILEKPLKLLTEEDISQLTREDCRKFLKEKGMRRPSWNKSQAIQQVLSLKALYEPGDDSGAGILRKILVSQPPNPPRVTTTLIEPRNELEACGRIPLQEDDGACHRRDSPRSAEFSGSSGQFVADKDSHKTVSVSPRSPAETNAVVGQMTIFYSGKVNVYDGVPPEKARSIMHFAANPIDLPENGIFASSRMISKPMSKEKMVELPQYGLEKAPASRDSDVEGQANRKVSLQRYLEKRKDRRFSKTKKAPGVASSSLEMFLNRQPRMNAAYSQNLSGTGHCESPENQTKSPNISVDLNSDLNSEDN
Protein: Uncharacterized protein At5g03900, chloroplastic (Q8GW20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Iron-sulfur assembly protein IscA, chloroplastic
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Iron-sulfur assembly protein IscA-like 3
- Iron-sulfur assembly protein IscA-like 1
- Alpha/beta-Hydrolases superfamily protein
- Low-density receptor-like protein
- 6,7-dimethyl-8-ribityllumazine synthase
- Zinc finger/BTB domain protein
- Inner membrane localized protein
- Protein FATTY ACID EXPORT 3, chloroplastic
Sequence:
MACVSTCLILSPRLTQVGLSSKKPFLIRLRSPVDRYSFPRMLTERCLSTRRKFNRHGIAVVKAASLDKVSGAIKPGGLVESDKLPTDVRKRAMDAVDECGRRVTVGDVASRGGLKVTEAQTALQAIAADTDGFLEVSDEGDVLYVFPRDYRTKLAAKSLRIQIEPFLEKAKGAVDYLARVSFGTALIASIVIVYTSIIALLSSKSEDDNRQRRRGRSYDSGFNFYINPVDLLWYWDPNYYNRRRAREDEGKGMNFIESVFSFVFGDGDPNQGIEEERWQMIGQYITSRGGVVAADELAPYLDVPSSKSAMNDESYILPVLLRFDGQPELDEEGNILYCFPSLQRTASGSSRRKEYVGKWFDWVADMEKFFKEKKWQFSKTSTSERALVIGLGAVNLFGVIVLNTLLNEMSVRPGGFLTFVKNIYPLLQIYAGSFFTIPLIRWFSIKRKNNQIENRNKARLQFARALESPDIALRRKLLSARDMAQKTVIGKDRIVYSTDRDMMEQNYETDEWDRRFKELEKSD
Protein: Myosin-K heavy chain (Q9XXV8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10403059}. Note=Enriched in actin cortex regions.
Interaction partners:
- Drebrin-like protein
- Serine/threonine-protein kinase pakB
Sequence:
MFRLFSSGVDDLVLVSNPSNGEVTSQIGARFDRELIYTNIGEVLIAVNPYKALPITGPEFIKLYQNASGSDASPHIYALAERAYRRMVDENESQCVIISGESGAGKTVSAKLILQYVTSVSPNNSSGGGIGGSGGGNGGIPQYDGGSDDRPSPPMGRGMGMPGMVGRGGLPTRGGGPPSRGGGPPPTRGRGGPPPPIPQNRGAPPPVSNGGAPPPVARGPVAPPPTRGAPPTRGGGPANRGGRGGGPPPVSTSRGGGGYGGSSKTVDVEHIKKVILDSNPLMEAIGNAKTVRNDNSSRFGKYLEIQFDDNNAPVGGLISTFLLEKTRVTFQQKNERNFHIFYQMLGGLDQTTKSEWGLTQATDFYYLAQSKCTTVEDVDDGKDFHEVKAAMETVGISRDEQTEIFRILAAILHVGNIRFQGEAPASVIDETPLQWAASLLGCDPTFLCQSLNHRQIQSGSARHTQYQVPQNPDQSAGLRDALAKTLYERIFDFIVARVNKAMSFSGNCKVIGVLDIYGFEVFERNSFEQFCINYVNERLQQIFIDLTVRGEQREYHEEGMKWKDISFFDNKIVVDLIDGNKPPGIMRVLDDVCKTVHAVDSAAADIKFMEKLIHSIQSHPHLVISNTGSSADEFTIKHYAGEVSYSIEEFCFKNNDNLYASIVGCLQNSTYQFIVSLFPENIQDNKQAPTTSSFKIRQSSSYLVTRLSACTPHYIRCIKPNDKKQPMNFVSSRVEHQVKYLGILENIKVKRSGYAYRQLKDIFLNRFGKIMDVQPRNVQEFVEYITRTHKDINADEFEEGKTKIFVKNPETIFVMEDLLMQKIDPIGYKNRVQAYKENEKLAQMKQGKHSMKQKCLIQ
Protein: UTP--glucose-1-phosphate uridylyltransferase 3, chloroplastic (EC 2.7.7.9) (UDP-glucose pyrophosphorylase 3) (F4IY62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of sulfolipids in the chloroplast. Catalyzes the first committed step in sulfolipid biosynthesis. Converts glucose 1-phosphate to UDP-glucose, the precursor of the polar head of sulfolipid. In addition to glucose 1-phosphate, can use galactose 1-phosphate, but with much lower activity. No uridyltransferase activity with other hexose monophosphates. Specific for UTP and cannot use ATP, CTP, and GTP.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19286968}.
Interaction partners:
- UDP-sulfoquinovose synthase, chloroplastic
- Sulfoquinovosyl transferase SQD2
- UTP--glucose-1-phosphate uridylyltransferase 1
- UTP--glucose-1-phosphate uridylyltransferase 2
- UDP-glycosyltransferase 78D3
- NAD
Sequence:
MANPQASPILHHPQNHLSLFHFRTTTSPRSFSSLHFRKPLLFLSSSSSFSSKLQQSEQQCNNHQVRHVSTVPVEYSTPTPPESDDFLSEIDRLKSLLSKLDVSKDLRRKDAVIDADSRVRRFFSENRGGLSKVFGYLGLNSNEMFLVKCVIAAGQEHALCMNYEEAFGEEEEEYTVRSSVKNALYALVEMIERFDVNSSGYKGRREMGTVLDSEEIAHFRKFLTFLEEIEQFYDCIGGIIGYQVMVLELLHQSSKRRNTNRSQLVEESLGCQYLEMHTPSVLDLTQEEDYASQAALWGIEGLPDLGEIYPLGGAADRLGLIDSETGECLPAAMLAHCGRTLLEGLIRDLQAREFLYFKLYGKQCVTPVAIMTSAAKNNHEHVSSLCERLKWFGRGQSNFRLFEQPLVPAVSAEDGQWIVSKPFVPVSKPGGHGVIWKLAYDKGVFNWFYDHGRKGATVRQVSNVVAATDVTLLALAGIGLRYNKKLGFASCKRNAGATEGINVLMEKKNFDGKWEYGISCIEYTEFDKFDISNRSPSSNGLQADFPANTNILYVDLHSAELIGSSSNAKSLPNMVLNTKKRIEYLDQYGDYHSVMGGRLECTMQNIADNFFNKFPSRCHGSLEDKLDTYIVYNERRKVTSSAKKKKPHASAALHQTPDGALLDILRNGYDLLTECDIKLPMIEANDKYVDSPPPYLILLHPALGPLWEVSRQKFKGGSISSCSELQLEIAEFSWNNVQVDGSLIVTAENAMGSTTPNDNGEPILQYGLRCGKCKLHNVNVVNRGIDWNSKSNVYWRNDVNRLETCKIILHGNAEFEASNVTIEGHHVFEVPDGHKLKITSGNAGLSINLEALKEEVMETGSWYWNYQLNGSHIHLQQVEVSQS
Protein: Uncharacterized protein C713.09 (Q9C1W6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSDREEKLAAAKQRLLEVKKKKRQAKSKNSVAEDNVDRESNDGNNQVNEPTGNDNTQVVENTEDISASNVVSAEGAEASTGDASTQSPETSENVVKNSVDESVAEKPEKEDLAVIESEDKAAKPDGEIKKNVETEVTSRSTSSQEKDELEKQVKTLHDLNEQKDKKIKELKERINDLTYDYETLKANADDSEGKQTLVSKREAALEEFQSKLLIRENEINKRELKMNGKEDDLKKREKDLENRLLKVEEHEKSLNERATKLSEANENFNNRFKEFEEREKSAIKQNKEQSSEGSKTANQTHEQKELINSLEKKVSDIALEKQLLEEAVERYKLAMVEFAECQRRLKELEAMHFEQPGSVTEKLFPDPTNFEVIDNVSIDLTLTGFPGAHGIPFSV
Protein: Peptidase S1 domain-containing protein (Q9VXP8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein
- AT26814p
Sequence:
MALNSERSLMLVLLAAISVVGQPFDPANSSPIKIDNRIVSGSDAKLGQFPWQVILKRDAWDDLLCGGSIISDTWVLTAAHCTNGLSSIFLMFGTVDLFNANALNMTSNNIIIHPDYNDKLNNDVSLIQLPEPLTFSANIQAIQLVGQYGDSIDYVGSVATIAGFGYTEDEYLDYSETLLYAQVEIIDNADCVAIYGKYVVVDSTMCAKGFDGSDMSTCTGDSGGPLILYNKTIQQWQQIGINSFVAEDQCTYRLPSGYARVSSFLGFIADKTGIAV
Protein: Delta-6 fatty acyl desaturase (D2Y364)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQQTESSEPAKGGVVGPGGGRGGRGGSAVYTWEEVQRHCHRGDQWLVIDRKVYNITQWAKRHPGGIRVISHFAGEDATDAFSAFHPDPNFVRKFLKPLLIGELAPTEPSQDQGKNAALVQDFQALRDRVEREGLLRARLLFFSLYLGHILLLEALALGLLWVWGTSWSLTLLCSLMLATSQAQASWLQHDFGHLSVFKKSSWNHVLQKFVIGHLKGASANWWNHRHFQHHAKPNVFRKDPDINSLHVFVLGDTQPVEYGIKKLKYMPYHHQHQYFFLIGPPLLIPVYFHIQILRTMFLRQDWVDLAWSMSFYLRFFCCYYPFFGFFGSVALISFVRFLESHWFVWVTQMNHLPMEMD
Protein: Olfactory marker protein (Olfactory neuronal-specific protein) (P08523)
Organism: Rattus norvegicus (Rat)
Function: May act as a modulator of the olfactory signal-transduction cascade.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MAEDGPQKQQLDMPLVLDQDLTKQMRLRVESLKQRGEKKQDGEKLLRPAESVYRLDFIQQQKLQFDHWNVVLDKPGKVTITGTSQNWTPDLTNLMTRQLLDPAAIFWRKEDSDAMDWNEADALEFGERLSDLAKIRKVMYFLITFGEGVEPANLKASVVFNQL
Protein: Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) (p21-activated kinase 3) (PAK-3) (Q61036)
Organism: Mus musculus (Mouse)
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Rho guanine nucleotide exchange factor 7
- Cell division control protein 42 homolog
- Rho guanine nucleotide exchange factor 6
- SH2/SH3 adapter protein Nck1
- Cytoplasmic protein NCK2
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 3
- Serine/threonine-protein kinase PAK 1
- Roundabout homolog 1
- Dual specificity mitogen-activated protein kinase kinase 1
Sequence:
MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
Protein: Ribosomal protein L2 (Q2F991)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPKMHLSFELLIEWNFAPETFLGEVRIRSVRILIGLGLTWFTRYWFSEESISPLAKPFLTLPLDSYFVRTQSTEAPPTYVATSSIACSYFVFPLISHQIWCFSIPSCYGEQRQKYNRFLHLSGSRFSLFLFLTPPRVVPNVWHFPYFVGATSTNSLMIKLQPKIYDYIMLTVRILFIPSVCSQVPVIVICLPEPRGLSVETFTSNRRFLMVFPLITAALSTPPDIWCQIVAPFLIYSIIEFAIFVALIVQVREEGWTIRMRGSIEKKEE
Protein: Non-ribosomal peptide synthetase OfaA (Q4KET1)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Interaction partners:
- MbtH-like protein
- Polyketide synthase/nonribosomal peptide synthetase hybrid RzxA
- Polyketide synthase RzxF
- Polyketide synthase RzxE
- Polyketide synthase RzxC
- AMP-binding enzyme
- Polyketide synthase PltB
- L-cysteine--[L-cysteinyl-carrier protein] ligase
- salicylate--[aryl-carrier protein] ligase
- Thioesterase
Sequence:
MNAGPVQARGLPLTAGQRDIWLDQLSRGDSPLYNIGGYAVLKGPFRPELMQRTVELLVDKHDVLRTVLSLEGSVDGLPLQHFDRQWPVELVFHDLSAAADPLAAAQAQIRRQMQQAFKLDGERLCRFSLFRVGPEHHLMEVEAHHLILDGWGFAQLSQSLGGLYSALASGEEPQATAPSFVDFIEDDARYHQSSRYARDRDYWLDKYQSLPEPVLRPRYRPAADAATPGATLVQAFPAALHERMKALGKSTGASAFHVLLAALHVYFTRTLQRDEWVLGMPVLNRPNAAFKVTLGSFTQVSAVRMDFGRELSFEALVGAVRDVLKQDFRHQRFPLSELNRALGLLREDRAQLFELSLSYELEDLDYRYGEAAASSVKVSNRHEPTPLAIHLRSNSFDDSAWMHYVYDSAYFQPEEIEALAARLLHVLEQGLDNVQLPVARFSLLPAAELRRLQAWNANEQPAAAEQRIHARVAAWARRTPQAIALVAQGQALSYEQLDRRANALALHLRELGVGPDARVAIVARRSPETLVGLLAILKAGAGYVPLDPAHPAERLAFLLHDSAPRAVLTQGALRQCLPTLNVPLIDLDNGQWLDGPGEIAEAAGLTAEHLAYVIYTSGSTGQPKGVMVEHQSLSNLVDWHGRAFDLQAGSHTSCLAGFGFDAMAWEVWPALCAGATLHLAPVSDGPEELDRLLAWWRAQPLEVSFLPTPVAEYALSQQLGHPTLRTLLIGGDRLRQLPADPGFAVINNYGPTEATVVATSGAIEAGQALHIGRPIANTRIYLLDEQQQLLPIGVPGELYVGGGGVARGYLNRDGMNAGRFLADPFSDRPGARMYRSGDLARWREDGSLEYLGRNDDQVKIRGLRIELGEIETRLGDHPAVREALVQARDGQLLAWFIPRQAVTALQLREFLRQQLPEYMLPMAYVPLDAWPLTGNGKLDRRALPAPGPGDLISRAYEAPQGPLEITLAGLWSELLQVEQVGRHDHFFELGGHSLLALQLIQRMAQAGLQADVRVLFGQPTLASLAAAVSTGQVVEVPANRVPPDCQRITPAMLPLVELDQDSIDRVVACIPGGAANVQDIYPLAPLQEGLLYHHMTAARDPYQQHALFAFAGREDLDAFALALQAVIERHDILRTSLVWDVLEQPLQVVWRQARLTVQEWQAGPGGHVAERLREHFDPQHNPLDIRQAPMLALAWAEDRANGRWIGLLRFHHLVNDATSTAVLLAEIAAHVQGRQASLAPAYAYRDYVARTRLGQAAHKAFFEAGLGTVDEPTLAFELQERPGEQLDLQHASGLLEAELGQRLRTQVRQLGVSAASLFHLAWALVLGRTSGREDVLFGSVLLGRLQAGAGADRALGMFINTLPLRLELAGLTVAEGLGQAQQRLSALLAHEQAPLSLAQRCSAVAAPTPLFNALLNYRHNLGGDLLQGLPGVELLSSEEVLSYPLMLAVDDLEPGFRLGCRAPRRIGAQRLLGYLSTALEALVLALEQAPQTPLHSLSILPPVESRYLLQTLNATRSQYPRELTLHALFEAQVRRTPEAIALQAGARQLSYRQLNQRANQLAHYLREQGVGPDVRVGLCVQRSPELLIGLLGILKAGGAYVPLDPDYPLERLRYLVQDSQPLAVLVHQPTRELLGPLPLSLIDFDRSTWEQAPQHDPVVAGLTVSHLAYVIYTSGSTGTPKGVMVEHRGLGNLMHWSSQLCGERARGTLLQKAPFSFDGSVWELFWPLVTGMRLLLARPDGQRDPLYLAQLVREEQVSMIKFVPAMLLQFLQLEEAGQCHSLTDVFCGGGELTEAIARLFRQRLPGARLHNVYGPTEATVDSSAWTLEPGAAVPPVQLPIGKAITNTRLYVLDAHDQPVPQGVSGQLHIGGVGVARGYLGLPQLQAERFIDSPFVAGDRLYRSGDRVRYNADGDLEFLGRNDFQVKLRGLRLELGEIEARLASHPALREVAVLMRGERLVAYFSLHPGVAAPGIEALRAHVLERLPEYMVPAAYVQLAALPLSANGKLARDALPEPGLEAVLSRDFEPPQGPLETTLARLWAEVLQVERVGRHDHFFELGGHSLLAVSLVARMRQEGLHADARLLFSQPTLAALAAHTLGQLQRLEIPATTIPQLKRQRRL
Protein: Nuclear autoantigenic sperm protein homolog (Q9I7K6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36930688}. Nucleus {ECO:0000269|PubMed:36930688}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:36930688}.
Interaction partners:
- Histone acetyltransferase type B catalytic subunit
- Histone chaperone asf1
- Chromatin assembly factor 1 p55 subunit
- AT24654p
- Uncharacterized protein, isoform A
- Uncharacterized protein, isoform D
- AT23003p
- GEO11065p1
- GH01761p
- DNA replication licensing factor Mcm3
Sequence:
MSAEAEAIVTTATADVSSPSKTVAVEPVAADTTPDNAPAVSTEGSGKAEQERAEKILKGKELFSQGSRNFLVKSYDEAADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMALDENKVIDVPDEAADDDDEDVDDDEEESAEDGAAKKEEKKDTKEAANGASSSNGKELDTIKEGSDEADSTGEAEQAQSDEKPSKKVPTGVDEVSSSNGGGGAAVNDDERPSTSNGEVTASCSNGAAPAVEEEPEEEEGVSGSLQLAWEILEAAAQIFSRQGLSGLPYLAEVQTELANIEFENGILEAAREDYEKALKIHGELPTRNRRALAELHYKIGLTYLMQQLNKEGATALRQSSVLIEEEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEIEEMQAQTIAEVRAALDSYIKPMSSGDAAAASSSSSSSANGAASSSSSSSKGAAAASSSTISSSSAKPTDITHLIKRKKPEDPSSEAEALCSPAKRAAV
Protein: Transcription factor 21 (TCF-21) (Capsulin) (Epicardin) (Podocyte-expressed 1) (Pod 1) (Pod-1) (Q6GNB7)
Organism: Xenopus laevis (African clawed frog)
Function: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43680, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MSTGSLSDVEDFQDMEMLECDGIKLDPNKEFGISNDSNEESSTCDNGSPKKGRGTSGKRRKASSKKSPLGTINQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPENDLKEVVSTSRLCGPTAS
Protein: DNA mismatch repair protein msh3 (Mating-type switching protein swi4) (MutS protein homolog 3) (P26359)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity). Involved in termination of copy-synthesis during mating-type switching.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA mismatch repair protein msh2
- Putative MutL protein homolog 1
- DNA mismatch repair protein msh6
- DNA mismatch repair protein pms1
- Exodeoxyribonuclease 1
- Sorting nexin mvp1
- MutS protein homolog 1
- Structure-specific endonuclease subunit slx1
- Proliferating cell nuclear antigen
- Crossover junction endonuclease mus81
Sequence:
MRGMSYNITHECDAINILSDNLHEGAISEDMVALSGPAIELLENNVGSSKNSYQEDEGSSSIDENAPLISIKRKRRIRTVKSTSNKELVQRKASKPTKQKSVFTPLEQQYLELKKNYQETILAIEVGYKFRFFGKDAKIASEVLGISCYFEHNFLNASVPSYRIDYHLERLINFGLKVAVVRQTETAALKSTSSSRNTLFDRRVARVLTKGTTLDDSFFRFEQTQHGTLQASQFILCVADNVDKSKAKSGRVQVGLIAIQLSSGTTVYDHFQDDFLRSELQTRLSHFQPCELIYSNKLSSESVALLNHYVSTEKTCGRVVRVQHAVQQDVKLALENLQDFFSSKCIMSGSKIIELHMEKVKSLHSLSIICLDMAISYLMEFSLEDLFVASNFYQPFDSISSMVLSKQALEGLELFVNQTDHTPVGSLFWVLDRTYTRFGQRMLQRWLQKPLVDKENIIERLDAVEELAFNSNSQVQAIRKMLYRLPDLEKGLSRIYYQRGFYKAASAFSKNSYSCFKSALLRRLIQQLPSISSIIDHFLGMFDQKEAENNNKVDMFKDIDNFDLSEEPNDVDYELAQEIRELKMSILMVRTEMDFHLQELRDYLEYPNLEFSIWGNVKFCIEVSKGCKKIPPDWIKLSSTRSLFRFHTPKIQSLLIELSSHEENLTISSEKIYRSFLSRISEHYNELRNVTTVLGTLDCLISFARISSQSGYTRPEFSDKELLIHESRHPMIELLSDKSFVPNHIHLSSDGVRCLLITGPNMGGKSSFVKQLALSAIMAQSGCFVPAKSALLPIFDSILIRMGSSDNLSVNMSTFMVEMLETKEVLSKATEKSMVIIDELGRGTSTIDGEAISYAVLHYLNQYIKSYLLFVTHFPSLGILERRFEGQLRCFHMGYLKSKEDFETSVSQSISFLYKLVPGVASKSYGLNVARMAGIPFSILSRATEISENYEKKHRNARKNVFIRKVAKLLMILNAEEIDFKRLFYDLTAFEEI