wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8JHE0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Glycogen synthase kinase-3 beta
- Axin-1
- Glycogen synthase kinase-3 beta
- Catenin beta-1
- Protein cereblon
- Axin-2
- Low density lipoprotein receptor-related protein 5
- APC membrane recruitment protein 1
- APC regulator of WNT-signaling pathway
- Suppressor of fused homolog.
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSLAVSSSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSGGQGQQAQTPTGKQTDKPKSNMKGF
Protein: Lysine demethylase 4A (D4A2N4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPERYKLWKAGKDSTVIDHTLPTPEAAEFLKDSGLTPRAGNEECPEEDSEAAEQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEELSSGQYEMTECQATLAPVRPTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAAALDLSVNPESVEGRLVFSGSKKKASSSLGSSSSQDSVSSDSETTESVSCQGQEKTVLTVHSYSRGDGKAAPGEPSVKRQRSAPRSISEQELAEVADEYMLSLEENKKTKGRRQPLSKLPRHHPLVLQECGSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNELMAQQAPHCAVCMIFQTYHQVEFGGFSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
Protein: F-box/LRR-repeat protein At3g59200 (Q9LX51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Late embryogenesis abundant protein 18
- Transcription factor NAI1
- Peptidyl-prolyl cis-trans isomerase CYP19-2
Sequence:
MDFVSRDRISSLPNPVVSHILSFLPTKEAASTSVLSKKWRYLFAYVTNLDFDDSDYQDGKPKSDVELSRSFMEFVDRVLALQGNGSVNKFSLECSNYDVDLARVTGWILNVLGRGVSELDLSILEYPLPSEIFVSKTLVRLKLGPANDLTLTLDRKDVFLPKLKTLYIDCVDVQERGFGFVKLLSGCPVLEELVLMNIGWENWKFCSVSVKTLKRLTFFCEETYENPKSVSFDTPNLVYLEYSDAIASKYPKVNFNSLVEAHIGLRLTEDQSGDADFSEEDYFSEGDEKKQMVGNATDFLKGISTVQILYLSAQAIEVLTFCCEPIPVFNNLIQLTIENNSEIRWDSLPGLLKNCPNLETLVLKRLLHKYNKACGNVCCCKRPKQPSCLSSSPVKVLKIFLFDDNDEEDGSEMRQIKYFLEKMPRLEELVVYYNTAYDPAVLELSKKLQKIPKIASPKCKIQVISENLSLSSTVPSFLTTRWSSLPPEEAYPWVDSPPPQIIDPMLEYGSPPEDDDSWLY
Protein: NADH-dependent phenylglyoxylate dehydrogenase subunit epsilon (EC 1.2.1.58) (Phenylglyoxylate:NAD oxidoreductase) (Phenylglyoxylate:acceptor oxidoreductase) (Q8L3B0)
Organism: Aromatoleum evansii (Azoarcus evansii)
Function: Involved in the anaerobic metabolism of phenylalanine and phenylacetate. Catalyzes the oxidative decarboxylation of phenylglyoxylate to benzoyl-CoA and CO(2). It can also react slowly with 2-oxo-3-methylbutanoate and use different electron acceptors such as benzyl viologen, methyl viologen, FAD or FMN, but NAD seems to be the physiological electron acceptor. Also catalyzes an isotope exchange between CO(2) and the carboxyl group which proves partial or complete reversibility of the oxidative decarboxylation reaction.
Interaction partners:
Sequence:
MDRAIEHTKYLIAGSSHAALEAINAIRMHDAEGPITVVTRDAHLPYSPTVLPYVVSGKSAPERIFLRDDDFFARNKVAYRPKAALKALHADRNTAELADGSSVVYEKLLLATGASPAIPPIPGIDTVSYHVLRTLDDALKLRGAIAESKQAVVLGAGLVGMHAAENLVKAGATVTIVEMSEQLTSGYFDKVAADMIEQAFRDAGGKIMTGSRVVRLEPTAAGAKLTLENGTTLEADLLLVATGVKPEMDYLNGSGVEHAQGILVDDRMQTTAENVWAAATAQARGFFTGTKVMNAILPDATIQGRVAGMAMAGDPGVKDYAGAVPLNTYHFFGRHAISVGSSTVPEGGEVVTRFDEKTGRYLKAIFAADGPLTGIFGVNEFFDGGVMAQLILRRTDLTPLRSRFVANPLAVGREIMSQTWR
Protein: Uncharacterized protein C17G9.13c (Q9UUD9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- CTO1 family protein C17G9.12c
- Meiotic expression up-regulated protein 27
Sequence:
MRFISTVTKRRPFQAPNDLVHPLSNILGSLVTYDSRLHLPQPKDRQCSTLVPLYRRLLKATRRFWDPMASQILISHFQAYARKARKSNPNPHKRRIKRFRNLLKTFACRIERANDGDHQAIWQTLRYAYSQTGPLRHRRLHYLQDNKIRPSKIPKSLPSNSPVRLPYISSLLSAVFEINMENAKIRHLPSVIFDGLIEKNKDRPYHINLSCKRAYDELLPRIAVPLLPHEYHHLHSLLLDVTLRNPQISRPPFAPLNPRKGFCRILQRSLITFLSAVCYLPYNPHPTSKPVVSWDSLSDIQLRLNVGKVLKKSVKKR
Protein: RING-type domain-containing protein (Q54CR0)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- DNA helicase
- Fanconi anemia group D2 protein homolog
- Fanconi anemia group I protein homolog
- DNA excision repair protein ERCC-1
- Nuclear protein localization protein 4 homolog
- Nuclear transport factor 2
- DNA repair endonuclease XPF
- Large ribosomal subunit protein uL1
- HECT-type E3 ubiquitin transferase
Sequence:
MVLNYVTICIGHMNLNEEPLFPLLIPTNKQQSEYSGFIQVLGKQYPIEIKLSNGCGNSINSETTSTLYIEDLEFNCTKELYDILLPHVQRFIQCKNIQQFFFELKDILDRITINTGTSTLTTSNKIITLPFDTFSLISNEIDEIGWNKVINIDKSLSSFEIMLLDIKEREFIVEFSIPIGYPTQFPFVKCDLPLNSTEFITKLRSINTSTNDNSFYNNNKNNNNNFENNNNNNNNNSISISNILKKIQIMIDYEYQEFFNFMEEIDSESWVLEPINPRRSSIFRRIAIGNGCSICFEVNPNQPRIAPYKVDFIGPSSKTQPLHQLWNKKYSAQQWFERSSPIDNFQKMLELSFPLKSMDNTLIEEIIIQCSICYTHHLPQNLQQETNNNNNNNNDNDNNNDNNNNNNNNNKLDNENNIKSMTSLPNVTCNNLKCSKQFHYHCISEWLFSLPTTVIGSSSINGPCPYCSSKMTIEKMLNK
Protein: Abnormal cell migration protein 13 (G5EF33)
Organism: Caenorhabditis elegans
Function: Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development. Associates with and recruits the downstream components tyrosine kinase abl-1 and the tyrosine kinase adapter protein sem-5 to the leading edge of migrating Q neuroblasts and their descendants to activate signaling through the two parallel wve-1 and wsp-1 pathways, respectively, and direct migration along the anteroposterior body axis. Involved in cytoskeleton dynamics regulating the organization of the actin cytoskeleton at the leading edge of migrating cells to ensure correct Q cell polarity and promote migration. Role in cytoskeleton organization may be by activation of the wve-1 and wsp-1 pathways which recruit the Arp2/3 complex to the leading edge of migrating cells. Plays a role in regulating the asymmetric distribution of the actin cytoskeleton-binding protein cor-1 in Q neuroblasts which is required for the anterior migration of QR neuroblasts.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10412978, ECO:0000269|PubMed:23784779, ECO:0000269|PubMed:27780040}; Single-pass type I membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:10412978}. Cell projection, axon {ECO:0000269|PubMed:10412978, ECO:0000269|PubMed:26762178}. Cell projection, dendrite {ECO:0000269|PubMed:26762178}. Note=Localizes to the leading edge of migrating Q-neuroblasts. {ECO:0000269|PubMed:27780040}.
Interaction partners:
- Homeobox protein lin-39
- Homeobox protein mab-5
Sequence:
MTKLLIALILFSICWKPYSAEPIASFFDGLDSRNECKARLDRRLTGFSGLLYSHSKYGQEPYNTSRNCVLMLVAPIGYSIRVRALQFDVASTENARTCEKDTLHVFDHETTLDPESYAPARIDDITSPGPIIGQFCGHFENRILNTSSHNALTLWWHSNPNGSNSKGFKLHWGSFRVSKTGNCVTGEFSCGNGECIPIESACDRFADCSNGEDLIHSRQMAANCQNIELDPLTTVSGVFVLLFSATIILSLCGFIMFVCCLCKCLKSTIPIKGASSHTTTTTATDYKPDPPQFYPPSPPKMPPPSAASSYTPRLHHHFEGPLVPSETSAFHSSNRMQNHYSVNSDINGDYTYVRNDVHRNLL
Protein: Ceramide transporter 1 (A0A2R8YFA1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
EDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREFIRL
Protein: Uncharacterized protein At2g37660, chloroplastic (O80934)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- NADH dehydrogenase 1 beta subcomplex subunit 7
- At1g72040
Sequence:
MAMMTTTTTTFFHPLLPANTYKSGAVASSFVSVPRSSSLQFRSLVSDSTSICGPSKFTGKNRRVSVTVSAAATTEPLTVLVTGAGGRTGQIVYKKLKERSEQFVARGLVRTKESKEKINGEDEVFIGDIRDTASIAPAVEGIDALVILTSAVPQMKPGFDPSKGGRPEFFFDDGAYPEQVDWIGQKNQIDAAKAAGVKQIVLVGSMGGTNINHPLNSIGNANILVWKRKAEQYLADSGIPYTIIRAGGLQDKDGGIRELLVGKDDELLETETRTIARADVAEVCVQALQLEEAKFKALDLASKPEGTGTPTKDFKALFTQVTTKF
Protein: PPFIA binding protein 1 (H0YFE4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XDIGLPQYKTQFDEGRVDGRMLHYMTVNTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV
Protein: Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Chromaffin granule Cyt b561) (CGCytb) (Cytochrome b-561) (Cytochrome b561) (Q60720)
Organism: Mus musculus (Mouse)
Function: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles (Probable). It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:16256064}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Note=Secretory vesicle containing catecholamines and amidated peptides. {ECO:0000250|UniProtKB:P10897}.
Interaction partners:
Sequence:
MEHSSASVPAALPYYVAFSQLLGLTVVAVTGAWLGLYRGGIAWESSLQFNVHPLCMVIGMIFLQGDALLVYRVFRREAKRTTKILHGLLHVFAFIIALVGLVAVFDYHKKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLFSVGTALLGLKEALLFKLGSKYSTFEPEGVLANVLGLLLVCFGVVVLYILAQADWKRPSQAEEQALSMDFKTLTEGDSPSPQ
Protein: Spectrin beta, non-erythrocytic 4 (E9PZC2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREAAERRQQTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELATCQELGRSLLLNKSAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAATELVRPRSERQELADRAEELPRRRRSERQESVDQPEETARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGIPAGVPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK
Protein: Gastrokine-2 (Blottin) (Q9CQS6)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000269|PubMed:16888721}. Golgi apparatus {ECO:0000269|PubMed:16888721}. Note=Secreted into the mucus layer, also present in Golgi apparatus and mucus granules.
Interaction partners:
- Trefoil factor 1
- Gastrokine-1
Sequence:
MKPLVAFLVVLSIFGIQSQAEEIFNIFVPSKNGGNIQETVTIDNQQNTATINIHSGSCSSTTIFDYKHGYIASRVLSRRACYVIKMDHKAIPALDKLQRFLYEKQTMNAIDSPEYTWVRYNPLKSLITKVDWFLFGSPIRQLCKHMPLYEGEVATKPKEVSTGACAKVGLLGILGVSICGGIHL
Protein: Small ribosomal subunit protein uS15m (37S ribosomal protein S28, mitochondrial) (P21771)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein uS5m
- Ribosome assembly protein RSM22
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL3m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS33
Sequence:
MSIVGRNAILNLRISLCPLFMGKRSFVSSPVSNSAKAVKFLKAQRRKQKNEAKQATLKASTDKVDPVLGRADTPFITRIMAELKEPLVLSKGYNIEEVDKFLAAIESAKRERAELSGLNTEVVGIEDIEKLEDRREAILRILSMRNSENKNAIKMAVELARKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGLNDAAITDEFNMDRRYMQDYEFFGDKILIRDSKKVANQKRKEIRKQKRATF
Protein: Uncharacterized protein YJR154W (P47181)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Dethiobiotin synthetase
- Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
- Putative aryl-alcohol dehydrogenase AAD10
- 7-keto 8-aminopelargonic acid transporter
- Peroxisomal targeting signal 2 receptor
Sequence:
MNTDSHNLSEPYNIGGQKYINMKKKEDLGVCQPGLTQKAFTVEDKFDYKAIIEKMEVYGLCVVKNFIETSRCDEILKEIEPHFYRYESWQGSPFPKETTVATRSVLHSSTVLKDVVCDRMFCDISKHFLNEENYFAAGKVINKCTSDIQLNSGIVYKVGAGASDQGYHREDIVHHTTHQACERFQYGTETMVGLGVAFTDMNKENGSTRMIVGSHLWGPHDSCGNFDKRMEFHVNVAKGDAVLFLGSLYHAASANRTSQDRVAGYFFMTKSYLKPEENLHLGTDLRVFKGLPLEALQLLGLGISEPFCGHIDYKSPGHLISSSLFENDIEKGYYGETIRVNYGSTQ
Protein: Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) (P36580)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate mutase
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Phosphoglycerate kinase
- Enolase 1-1
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Probable transketolase
- Enolase 1-2
Sequence:
MGILDIVPTGVITGDNVLKLFTYAREHGFAIPAINVTSSSTAIAALEAAREARSPIILQTSNGGAHFFAGKESSNEGQKASIAGSIAAAHYIRSIAPFFGVPVVMHSDHCAKKLLPWMDGMFEADEAYFKIHGEPLFSSHMLDLSEEPKKENIAQVKEYCKRAVPMKIWIEMEIGITGGEEDGVDNSHVSHTELYTQPEDIWDVYRELSSVTPYFSIAAAFGNVHGVYKPGNVKLQPALLGQHQAYVKEQLKTTNDKPVFFVFHGGSGSSVNEFRTGIKCGVVKVNIDTDTQFAYVEGVRDYVLKYKDYLMTPVGNPEGADKPNKKKFDPRVWIHEGEKTMTKRVLTALEDFYTVNTL
Protein: Methyl-CpG binding domain protein 1 (A0A8I5ZMU8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIRSKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGPQRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSWDGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPNDVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCLQRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVYDCVEEDELKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPPGPVQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPGWVVALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDGEENKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRCAPYS
Protein: Doxorubicin resistance ABC transporter permease protein DrrB (P9WG23)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell membrane {ECO:0000305|PubMed:12057006}; Multi-pass membrane protein {ECO:0000305|PubMed:12057006}.
Interaction partners:
- Doxorubicin resistance ATP-binding protein DrrA
- Probable doxorubicin resistance ABC transporter permease protein DrrC
- Phenolphthiocerol/phthiocerol polyketide synthase subunit E
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Phthiocerol/phthiodiolone dimycocerosyl transferase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit D
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Long-chain-fatty-acid--AMP ligase FadD26
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
- Multidrug efflux system ATP-binding protein Rv1218c
Sequence:
MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP
Protein: T. brucei spp.-specific protein (Q384Y4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWIGIADFFFFYHTLLMLLPNTKARAHTHTHIYIYIYKYIHKHIQAHARVIDPLIQCSIAGTVIPPVCYICSPLFRVSLVFLQFFLLFFFFFFFPPLPLRQTDVHACKPAHPPNLSTCFFSFLFSFLFTAVVVSFFFFFWLFRFFPFFIIFVIIYSCPSVLFPFRFLPSPCTRNLLCPRIWW
Protein: Copine 3 (E5RHZ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTGRPAGKGSITISAEEIKDNRVVLFEMEARKLDNK
Protein: Alcohol acyl transferase 1 allele GSa (AAT1-GSa) (EC 2.3.1.-) (A0A498KFL4)
Organism: Malus domestica (Apple) (Pyrus malus)
Function: Involved in the biosynthesis of volatile esters which confer ripe apple fruit flavor. Alcohol acyl transferase that can use a wide range of alcohols as substrate, including 2-methylbutanol, hexanol and ethanol, to produce esters such as butyl butanoate, butyl hexanoate, hexyl butanoate, ethyl butanoate and ethyl hexanoate and, to some extent, 2-methylbutyl acetate (2MBA), butyl acetate, hexyl acetate and 2-methylbutyl butanoate (2MBB).
Interaction partners:
Sequence:
MMPLAVLHVKRLQPELITPAKPTPQETKFLSDIDDQEFLRFQVPIIMCYKDNPSLNKNRNPVKVIREALSRALVYYYPLAGRLREGPNRKLVVDCNGEGILFIEASADVTLEQLGDKILPPCPLLEEFLFNFPGSDGIIGCPLVLVQVTCLTCGGFILALRLNHTMCDAAGLLLFLTAIAEMARGAHAPSILPVWERELLFARDPPRITCAHHEYEDVIGHSDGSYASSNQSNMVQRSFYFGAKEMRVLRKQIPPHLISTCSTFDLITACLWKCRTLALNINPKEAVRVSCIVNARGKHNNVRLPLGYYGNAFAFPAAISKAEPLCKNPLGYALELVKKAKATMNEEYLRSVADLLVLRGRPQYSSTGSYLIVSDNTRAGFGDVNFGWGQPVFAGPVKALDLISFYVQHKNNAEDGILVPMCLPSSAMERFQQELERITQEPKEDICNNLRSTRIMSMM
Protein: Putative methionyl-tRNA formyltransferase (EC 2.1.2.9) (Q9UTG6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Formylates methionyl-tRNA in mitochondria and the cytoplasm. Responsible for the formylation of the N-terminally formylated (Nt-formylated) mitochondrial matrix proteins that are encoded by mitochondrial DNA. Nt-formylated proteins in the cytoplasm are strongly up-regulated in stationary phase or upon starvation for specific amino acids and are targeted for degradation by an E3 ubiquitin ligase-mediated fMet/N-end rule pathway. Increased Nt-formylation of cytosolic proteins appears to be important for adaptation to these stresses.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P32785}. Mitochondrion matrix {ECO:0000250|UniProtKB:P32785}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Dihydrofolate reductase
- Phosphoribosylglycinamide formyltransferase
- C-1-tetrahydrofolate synthase, mitochondrial
- C-1-tetrahydrofolate synthase, cytoplasmic
- Probable serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- Probable aminomethyltransferase, mitochondrial
- Probable methionine--tRNA ligase, cytoplasmic
- Probable methionine--tRNA ligase, mitochondrial
- Methylenetetrahydrofolate dehydrogenase [NAD
Sequence:
MAPKIPLNVIFLGTDEFSIPILRKLIGCVQRVRVVSAGGKRQSRRGEIPLPPAAMEANANGLEYIKLQDGWKNFHMRPDDQLAITASFGRFVPFKILNQLPYGGINIHPSLLPKYRGAGPVYSTILNGDRLAGVTIQTMDSKQFDKGKSLAQAYLKLNGKETYTLLTKILSLGAAGMLEHVLLQSLYLPNCQTNTVAPQIHGRITDTGGLQLISKETFPSFQESWAKKITPEDAHVNFESMNTQQIYNMSRAFNHVWCILNNKKVFLYDVHPLHSTSAEDWIHMKPGEFALLEKNLLLVKTLDHVMVIKGGIRLSARKIVDPVEWGKTFNSGRGGRFQYV
Protein: Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) (P26641)
Organism: Homo sapiens (Human)
Function: Probably plays a role in anchoring the complex to other cellular components.
Interaction partners:
- Elongation factor 1-delta
- Elongation factor 1-beta
- Elongation factor 1-alpha 1
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS3
- Elongation factor 2
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein RACK1
- Translationally-controlled tumor protein
- Large ribosomal subunit protein eL19
Sequence:
MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATENAKEEVRRILGLLDAYLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAETQPKKDTPRKEKGSREEKQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWEHFDKDGWSLWYSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGVWVFRGQELAFPLSPDWQVDYESYTWRKLDPGSEETQTLVREYFSWEGAFQHVGKAFNQGKIFK
Protein: AT5g05480/MOP10_2 (Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein) (Q9FFG6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPENQNGAVKFFFTLAFLTATAVSRPSSPDRFLRSASTCLRSPVEPQEYEELRRPLPSDQLTPSCSHVLFRHSFANTINRPPFTTPYTPPSSCISPPWSYVVLDLRAASSGDQYDRISGLWLGGVELLRTSTAEPSPSGIFWNVRKDVSRYSSLFMRSDLNVTMMLENIVNDVYTGIYHINVTLIFYEFNPIASNLKISNRLGFVDSQKRDQTPADLIIPVCDGGNRGFWFMIENPRETYSKGIQIPSNTRQIVLELYVSFHGNDEFWYSNPPNSYIRTNNLTTGRGNGAYREVFVKIDGRYVGSEVPFPVIFTGGINPLFWEPVVAIGAFNLPSYDMDLTPFLGLLLDGKSHEFAFGVNDGISYWLVDANLHLWLDHGSSNVEAGSRLYDSPSRHMMRQEQLEQLDGSFKVEAEVSSEYDGWVRSSKGNLTTMVKSMFKVDSLVRFEKNGTYKRVEQRVKTERIVEVTSESGKPVNRVVHQRTYPLTVITSTLRGLTNDKDTYMLVTNVSHALNETHSDGEALIQVYSRQDSEGWMEVEDHNVLAGEASTKQSLSYIDEFSCYSRTIVAANGEIAQDSSSDSCTSSSFSELNTIEQLIITNVMKHLS
Protein: Trans-sialidase (Q17489)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSSTANYIVSGVLSDGTPIVFGAVPSDGTSHTAIHHVNSASHFQVESWDGEHAEHPQESEEPRRFSIFLEAGGAEKDGSSPFDNQEEDEPIASCKQFERTRSASLAAALLELDPRGVPLVQFFKLATDEPLFEVDEGEDEVEPTEAELVLSQLLFTLRSLKMSEADGKHSEAVQRLRELEEELRAAGAVTPSDPAVTEAVARALAVAGAGRDVQIRVNQSKHTTTTKTVYETETSAMAHMDVDQIRKLQQDIIADISSGAEQHSGQDSGTTQKKETAEEGFTNEDGSVVVSKKMTRVVTTTRTTLPGEGEEPSAPGE