wanglab/gogpt-training-data huggingface dataset:
Protein: Paired immunoglobulin-like type 2 receptor beta (Activating receptor PILR-beta) (Cell surface receptor FDFACT) (Q2YFS2)
Organism: Mus musculus (Mouse)
Function: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Paired immunoglobulin-like type 2 receptor beta-2
- Paired immunoglobulin-like type 2 receptor alpha
- Tyrosine-protein phosphatase non-receptor type 11
Sequence:
MALLISLPGGTPAMAQVLLLLSSGCLHAGNSERYNRKNGFGVNQPERCSGVQGGSIDIPFSFYFPWKLAKDPQMSIAWKWKDFHGEVIYNSSLPFIHEHFKGRLILNWTQGQTSGVLRILNLKESDQAQYFSRVNLQSTEGMKLWQSIPGTQLNVTQALNTTMRSPFIVTSEFTTAGLEHTSDQRNPSLMNLGAMVTMLLAKVLVIVLVYGWMIFLRWKQRPAH
Protein: Ras guanine nucleotide exchange factor N (RasGEF domain-containing protein N) (Q8IS12)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis.
Interaction partners:
- Rho GTPase-activating protein gacQ
- Ras-like protein rasD
Sequence:
MSYNSLTTIDIDITQLLHLKSVNLRSNKLGNSSGVSYFGSMDTLQKLNLKENYLTELPSTFYLLKLSSLKLDTFTPLYQQQQQQQNQLQRPIINSQSTSNESLIHEINRSFENLSMSEPVSPRIAALKNEKKGPPKPLPKTKGLHSSSSNINTSNNITPILMSPIHDGNKKSPSIISNNNNNNNSNSNIITSNGTVIPQLVFKNEPTGGRLRSFTLDADHISPGRELVSTGSSDEILYFNSEGGCENSDSDEPIQPLSAGRSRAQTISGKQPSIINNNNNNNSGGGSGNNNNSGGGGGSRKAFQNLIKSAKQIGSNIKNKTHHINGHSSSSQSNSTTNTPSISSTPYPTSTIKTNVSDTNTPVNYNGQQQISKVIQRVSGEIDPLYSGIDSPRTLERRNSSRDDIPISPPQGCMTPIKRLGSVEGDEISAIFSSSTDANMDVSQDYSSSTPTVNSMSYQSSFLDTFDNQSTVGSPTFYQLPVSSQPPQHPPPPPPIKDNNQPKLNQSQNLINTNSNSVTTTNNSSQTTTTTTTTTTNNNNVLNLEKLHKLDFAEDINGDERCSNPLYSKKKLAGLLFPNKHHQPSALKTAKIRFKSSKRLATTVNSNSSNNLMMSNSPLSSSSMNLLQQSNSPQYSGTPTSGSFQNQSVLSATLMSSPSMSDVFSGGNSQGGGSSLSQSGSITPVAPLSAVQGSPIGNSGSVNNIYLEGDDFIRDLMQSPIINQEIEFTSEDGVPKVKNITLKMLTSLLTHEKGQSNELNGIFFDTYLLFTSIPLVIEHLESRFLNGKNHIVKQKVITFSQKWVEVCWSDFKEEHIELLLKFLNDCSEQIEKLVTGSFALRTSLNLLLNIINMKRDGTYITEEEETFEQPAPIPDFIQLPNCVDINLMDLRPHEIARQLTILDHELLTQITKQQMLDYAVHQTNSPSIVKVTDRFNYLVLWVSTEIVLSLTIEKRIETIFKFVNIALNCWYLKNFNSAIAIIAAMSKPSIEKLKQTWGFIRNTKANAPIQELKELILPTNVARLRKIMDSVEAPFIPYLGAYFSHSIAIHAGNKSIVNEQYINMQKYDMMGKIIRSITVAQEKKYNLTPVGVLQKFLTDSFVLTEKQLYSEASKIEEKGDSYITETTKFGSIFKKKDK
Protein: Protein lin-7 homolog (Q66IB0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
Interaction partners:
- Peripheral plasma membrane protein CASK
- Protein PALS1
- Calcium/calmodulin-dependent serine protein kinase b
- Membrane protein, palmitoylated 5b
- Crumbs homolog 3a
- V-myb avian myeloblastosis viral oncogene homolog-like 2b.
- Adenylyltransferase and sulfurtransferase MOCS3
- Crb2
- Crumbs-like protein 3b.
- Peroxiredoxin
Sequence:
MASLGEPVRLERDISRAIELLDKLQRTGEVPPQKLQALQRVLQSEFCKAVREVYEHVYETVDINSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGTVKLVVRYTPKVLEEMESRFEKLRSAKRRQQNNFPK
Protein: Casein kinase II subunit beta (CK II beta) (P08182)
Organism: Drosophila melanogaster (Fruit fly)
Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Interaction partners:
- Casein kinase II subunit alpha
- Ste:CG33242
- Stellate protein CG33239/CG33241
- Stellate protein CG33238
- Stellate protein CG33237
- Stellate protein CG33243
- Stellate protein CG33236/CG33240/CG33244/CG33245
- Stellate protein CG33247
- Stellate protein CG33246
- Segment polarity protein dishevelled
Sequence:
MSSSEEVSWVTWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPNYRQALDMILDLEPEDELEDNPLQSDMTEQAAEMLYGLIHARYILTNRGIAQMIEKYQTGDFGHCPRVYCESQPMLPLGLSDIPGEAMVKTYCPKCIDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPTNQFVPRLYGFKIHSLAYQIQLQAAANFKMPLRAQRGQPPKDEEPENNADTVPKRL
Protein: Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1) (D4A9L2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine/arginine-rich splicing factor 10
- SRSF protein kinase 1
- Serine/arginine-rich splicing factor 7
- Serine/arginine-rich splicing factor 2
- Serine/arginine-rich splicing factor 3
- Transformer-2 protein homolog beta
- Splicing factor U2AF subunit
- RNA-binding protein 8A
- Eukaryotic initiation factor 4A-III
- U1 small nuclear ribonucleoprotein 70 kDa
Sequence:
MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRGSPRYSPRHSRSRSRT
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (Q54LJ4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVVNKNSVLNNLTFYLDCGNSGLKSKKVLQSYVESHGGNVSMILNQKINYYIFSGDFNDLIKVDEKNNNNNSYQDEEEKKNINLETLSSNIKKAIKLNIPIVSKRYLEDSISNGNLLSPNEYSLVSLYNIKEYHYKSLDFSNLLEDPSSSSSSSTNGEQQQQQYERIKYNNKVENDKFPTESKYHVVKHNVLISPKAESFICLELHVAGKILELIKTGNSDNSGGSGDQTQSYYRVFLNYGSLDANKINDSVKEWIPFTNLENSLDQYNEIFKDHLINKKYSKFQLGSTLIGSNKLQELCYNKLFDDTTITTTNNIDDSNNINNEIPKPIHELIKILYDEAISTLGNKFGNGSKLHLSPEGSIKTSMGDITLMQVDKAELSLFQLSTVLRGNGGKIDSKESTDLIDEIFRSLPQLKPPGGKFNNSYELLNDIQESVQLMKDILSVGESLSGVSKTLTSASSGEMAKYRALRCQINQLDKSSKDFKRITDQIKGGTKIEGLTQPQQSIKKSNGNDNNNNNENCIDNNNNNNNLIKIKNIFKIIRKEEDNYNFEVGNLKTLYHGSNPSNILGILSRGLLTPNVSTSIGAGRRDIGYLGSGIYFGVKPSTSIQYCKASTKTLSKYMFICSVALGQIKKYTTHQTQLSKPPKGFDSVQGVGSSSSSSSSSSSSNNTVKQSDFIDDEIVIYDSKQQKIQYLIEFDDLNSLTIPPILKSSLSSNNDKLLEISKESVKPTIESEKVPNSLPQKSLIDDSNDDDDNQEIGLISKNGGGDNAIPLKSVHVKGKILDLIGEVTIYQHYQNNSKNMIEAKYVFPLDEMGAVCGFEAYVNGKHIIGECKEKEKAQREYREAVAAGHGAYLMDEDKPDVFTVSVGNLPPNCDVLIKIVYVTELSIDGLDISFVLPRSITPKQRLQSSSSNTQSVTSTVQVTELAQKQSDLSISVGIEMPYNIVKLISPTHDVRIKRTHTKATIELNNQDNQYLDKNFQLLIGLEEPYSPRMWVEVDEKGHHASMLAFYPKLDIDNTMKDSHTMVTLLIDLSSSMAGDAFEDLLRAVRITISNLRGMQKVLFDVVCFGDTFDWLFGIGVPPTESNLQIAWSHINHLKTSYGGTLLHQPLQSLYLLAEKAKPTNPHNILLFTDGNVANEELVQMLVKKASPYCRMFAFGIGEHCSRHFVKSICRLGGGYPEFIQTNKRPNPKKIIDQLQRLTQPAMSNISVKFDSSDTNSIVQSPATITSIFKKERQVMYAFSGICTRATLICQAPGGGLITNVVHTPEIGFIKGNLIHRLAARSMIREYQDGTYSQNKHEHDLIKLKKKNDVIDLSIKYSIVTPFTSFVAVEKREKHETFSKLPPIQSIISQTIVDSLPYIAWEDKSQGIDQDPNDPILLNKRDQLSKLIEQYHSNSKFSDTINVFHQISDTFGEFSMKELNLLSDTINNLISKRVDKLSINDDSTTTTTTTPTTPSKLLREKKKLKEDIIYQGKGLLRLLESSTNHSNNEEAIISLMNNQCTVYKSLLNCDDNKYSKKQWCEKFESTLKSALQRSENSLSPTNPILLQLSLLSANYYKENGDFEKSIQISKNTFDKAISELDTLSEDSYKDTTLLLQLIRDSTTECLQFIEDEQEINEFNLDQRHQHQPENNVDNEPKDEPQIESTISSKQWSITPKKLGIKKATTTYKPIVVNQIVSNNNNTDIDYEGGVSENQSESGSDSESDSFSNEVSLRGISFDKYRCVTRSRSPSPEGNIRSNNSSRGEVSLRGISIDKYRCVTRSRSPSPEGNIRSNNSSRGRGGSSRGGSIGSSRGGRGGNIGTAFGRGAPPPPQPPPPPSTSLGRGAPPPSLFFQASQPYSPTSPFYIPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSTSPLYASTSQSYSPVSPSYTPTSLLYAPTIPSYSPVSPSYAPTKPSKLPVLTSYSPSSPSFSKSKAKEESTLSEINLPSKPMVAGYSRMSTVSFSSTPTPTPTPTPPPLPNAPRPSVSTNVFSPAPPAPQVFGGMMRRSSAHIGYSPEKENLQEERNISKKSDGMPRFKRTTLPPQPSSSGPPPPPPPSSSTSKNNSIEANSLKSDEGSLLNSIKRGYSLKAVPEKLKEEAKTIDNLSAQLINSLSRRRVAIDCIENDEDDDDDDAWSDEPVKKGGSGGGGSGSSYSFGGVPNAITSLVTASSTPASYLAAKSQPKDEEEEWGDEDMGFDLFGDYPTSSTTTTKAAATTTVSKPTSLPKKKESYDEDEDMGFGLFGDEEDYQLQRVLSQSLYESKQIQPQQPKSGPQKEQEESDGEGDCGFGLFGEYDDYCPPPPKSQPQPQLQSQKQQERKEKEQEESDEEEYCGFGLFDDNEDYVSPPPKYLSSSSSSSSSLSLSKDGSRSKLSKSKNEDIFNSSSSIIGKSWALETEKEEKEKKKKSKKEDKSNDIMKQKQQQLFEKEIVTLYSDLLMIVNSPTSYETVKKVSLALGVSRSSLIKFDSTLGGQLSDNFRFFILELIKIFVKLLKPSTTVSFEVIISKCNSTTGGSVLKSFGIKDDVITGIVKLSKKSHLFK
Protein: alpha-1,2-Mannosidase (EC 3.2.1.-) (Q2UMC2)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Cytoplasmic vesicle lumen {ECO:0000256|ARBA:ARBA00004321}.
Interaction partners:
- alpha-1,2-Mannosidase
- Mannosyl-oligosaccharide alpha-1,2-mannosidase 1B
- alpha-glucosidase
- alpha-1,2-Mannosidase
Sequence:
MSFHYPPRNPSLSPQPPLENNSWRASRSPGPKLGGYGLSQSAGVSNNLTTFFGDGRTLPMYKDKPYFAPRRTGPKVRQRRVLYGGLCLFFLVSLWYYMSGSWGKPEIKTSESQKGEELWAWVQSLDKEPAYNGEELKGIDWAARREKVRDAFIVSWDDYAKNGWGLDQYRPAAKDGKNMVEGGLGWIIVDALDTMIMMNLTSRVQHARDWIQHSLQYNQDHDVSTFETTIRMLGGLLSAHYLSTTYTDLAPVSGDEDLYIEKATDLAERLSGAFESSSGVPFASINLKKSEGIPAHSDNGASSTAEATTVQLEFKYLAKLTGEAEYWRMAEKVMEVVDRSKMEDGLVPIYIYPDTGKFRGKNIRLGSRGDSYYEYLIKQYLQTSEQEPVYKEMWDEALIGIRKHLVAYTKRAQLAIVGERPEGLEGKLSPKMDHLVCFLPGTIALGATGGIPLSQAKKSPYWSQRHDEEILLAKELMKTCWATYLATKTGLAAEITYFKLDNPAVMMQDMYPESTLTTGNRKSEQEDLPLKSKPLYPLDDKTLNWENDLDIHMQDRHNLQRPETLESLFYMYRITGDETYRHWGWEMFKSFVRHTAIVEHDNTHADPTSDKPAEPSRPQIISFTSLNNVDVIPPTRRDNMESFWMAETLKYFYLLFSDRDFIPLEENVFNTEAHPFPRFKLGGELRTGWERKSSESESVPGSAPQEQEQAP
Protein: Transmembrane protein 60 (Q9H2L4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRMSLAQRVLLTWLFTLLFLIMLVLKLDEKAPWNWFLIFIPVWIFDTILLVLLIVKMAGRCKSGFDPRHGSHNIKKKAWYLIAMLLKLAFCLALCAKLEQFTTMNLSYVFIPLWALLAGALTELGYNVFFVRD
Protein: C2H2-type domain-containing protein (J9VT45)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Interaction partners:
Sequence:
MDVLDLVNDHNHVGAGHNVQARPYVCTFDTCDKAFARKSDLARHFKIHTNDRAFACTYRGCGKSFIQRSALTVHYRVHTGERPHHCETCNKAFADSSSLARHRRIHTGKRPYTCHAAGCGKPFARRNTLLKHFKRQHPGLPPPSTAAQRTSIPAPVQSLGPRSSTASMLSQQSLNSNAERYTASPSDAGAPHGFAAPHPSEGAAYSFHGGFPERVLGGHSSAQQPIIFQGSGGIRPHFQQSPLPPGSLSLTPISTSGPHFAGGHGTQTPTSPAHHDRNKHGISPVSSIATNTFGSGQYASPLSAYPHASSYPLTRITSDSGIMWHKPLSAPGEPRYEASQWSGGNVGAGFHTSQLSVPQTPTHLSPSYPYHLPMQQRSATNPLPKTRQLYSPSCNGSDDERDEPLVSLSDAHPTFAIHPPQGIVSVPISSVEGPNISHISSHDGQILFAPSQNGQLHSAPPAIQRFNSMPAVPTMSSWGQNPQYQTQSVGSAKSADEEWEELQKEMLSREASVGADKELSPATEEGKTPKDGEPINHWGETIAYPVHPDLQHAKDPFHSTSSTFIHHMHSSDPLPPIQVFSNQPHHMVLTPINPNGMYPTPITAGEEWAQRHIKPTAMLGRGYPQQQIDVQNKENANEIAEHITLATPPKYQEDRKDSRSVTAVGLGIANVHFDEPQAIEGGDASEVKMEDLESEESDVAPEDDSDDEFVLGRKPRKGAKKGGVRKRGARTTTKRRRS
Protein: GATA transcription factor 21 (Protein GATA, NITRATE-INDUCIBLE, CARBON-METABOLISM INVOLVED) (AtGNC) (Q5HZ36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. Involved in the modulation of chloroplast development, growth and division in a cytokinin-dependent manner. Repressor of the gibberellic acid (GA) signaling pathway that represses flowering and modulates greening, in a SOC1-dependent manner. Prevents the accumulation of SOC1 during flowering. Promotes chlorophyll biosynthesis throughout the plant, by regulating chlorophyll biosynthetic genes (e.g. HEMA1 and GUN4) and chloroplast localized glutamate synthase (e.g. GLU1). Involved in the regulation of sugar-sensing genes (e.g. HXK1, HXK2, STP13 and PLT6). Regulator of germination, senescence, elongation growth and flowering time. Influences also leaf starch content.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00094, ECO:0000269|PubMed:22811435}.
Interaction partners:
- MADS-box protein SOC1
- At1g32630
- Transcription activator GLK1
- Transcription activator GLK2
- GATA transcription factor 24
Sequence:
MDSNFHYSIDLNEDQNHHEQPFFYPLGSSSSLHHHHHHHHHQVPSNSSSSSSSISSLSSYLPFLINSQEDQHVAYNNTYHADHLHLSQPLKAKMFVANGGSSACDHMVPKKETRLKLTIRKKDHEDQPHPLHQNPTKPDSDSDKWLMSPKMRLIKKTITNNKQLIDQTNNNNHKESDHYPLNHKTNFDEDHHEDLNFKNVLTRKTTAATTENRYNTINENGYSNNNGVIRVCSDCNTTKTPLWRSGPRGPKSLCNACGIRQRKARRAAMAAAAAAGDQEVAVAPRVQQLPLKKKLQNKKKRSNGGEKYNHSPPMVAKAKKCKIKEEEEKEMEAETVAGDSEISKSTTSSNSSISSNKFCFDDLTIMLSKSSAYQQVFPQDEKEAAVLLMALSYGMVHG
Protein: Beige protein homolog 1 (P25356)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in protein sorting and cell wall formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15296494}. Membrane {ECO:0000269|PubMed:15296494}; Peripheral membrane protein {ECO:0000269|PubMed:15296494}; Cytoplasmic side {ECO:0000269|PubMed:15296494}.
Interaction partners:
Sequence:
MNSIINAASKVLRLQDDVKKATIILGDILILQPINHEVEPDVENLVQHELTKIIQGYPIQDNMIINSKKGTVEDDLCELNNYTCFALSKSFDLCHDSRNFNIAQPKRWIQLLETLTDSVSFAVIVQIILTLSNISLINKQTLGKLKKLRIRIFEILSNKNDSWKSTLLQKNLIEWYIFMLSVDCTPLELQNLYLHKELKFCNGILNSLTLQVSDPRSQNYLQFENTYKLFQIQKSSRINNSFLFYIEFNSVTSNRIMTIERHIYLEIKEGQFCISNDNYIIGLFENFEFEAGTLYFIGVLIDHNNRITLYVDGSMINQLTLFENSICQLSTCELGSMICSIKVYRFYLWDGLLTEFAINILQAIGTNYQYTFSKKKEGPEVLSLCQDFLIAKAHLMARPTTEISSTKYIDEIELLEMENIIIDVNPNDILQDFTESSNFTVKFEESTNSKNIPEVGKCYFYRSSNLVSKFVSIDSIRLAFLNMTESGSIDDLFHHVSHLMNLLRNIDILNWFKKDFGFPLFAYTLKQKITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTDAYENIVLNLDLWYMNEDQSSLASGGLEIIRFLFFQISSLMEASIYSKFNSNKFNDMNILEKLCLSYQAVTKRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSYYFIKRKDVRSTEIILQAVDQLFSFYLDQGSDENAKILSEIIPLKLILMIMDQIVENNESNPITCLNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEIISLLLTYSIGNYTTANEIFSGAEDMIGGISNDKITAKEIIYLAVNFIEWHVINSNASDSSSVLDLNNHILRFVEDLKSLSAVPINESVFDPKKSYVMVSLLDLSIALNESEDISKFKSSSKVISELIKGNIMCALTKYAAYDFEVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEILNDLVDSNNNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVIQIDKSSFYHFKNVSKSQLLQDFKICIMNLIYSNTLKQIIWEKEEYEMFSESLMAHQEVLFAHGACDNETVGLLLIFFANRLRDCGYNKAVFNCMKVIIKNKERKLKEVACFFDPANKSEVLEGLSNILSCNNSETMNLITEQYPFFFNNTQQVRFINIVTNILFKNNNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRKDNTSLDFKIKKSISRYTYNLKTDREENAVFYRNNLNLLIFHLKHTLEIQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEPKYEPLINEEDANQDTITGGNRQRRESGSILSYEFIEHMETLESEPVGDLNENRKILRLLKDNDSIATIWNCSLIIGLEIKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEINDRGNSIVARNGIGKASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLENADSAPFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFFFLPEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIACNVQQLTTEVWRKVPMKPIFEKTIFNLNEKNRSVDYVIHDPSYFDSLYWRGFAFPNLFFRTEESLVSLRIVHKNWLKIGLDIFKKTHMAQITSFAYWKLGEFITGDKNGLIKVWKYRKDKHSVSGNLENKKTMFGHLCELKEMRCYHDYNTLLTLDISGLVYVWDMINFELVRQITNDAQKVAISQHAGSIMVLTKNNAISIFNLNGQIYTSKKFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYELFLNFHNEWAIKLLKQLCTEKGKAITSIKGQGKTYLSQKRRKDTAEPHEIEVIAGTLDGRLAIWY
Protein: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (EC 2.4.2.21) (N(1)-alpha-phosphoribosyltransferase) (Q05603)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Able to use a variety of other nucleotide bases as substrate to create alternative lower ligands for cobamide.
Interaction partners:
- Bifunctional adenosylcobalamin biosynthesis protein CobU
- Cobyrinate a,c-diamide synthase
- Adenosylcobinamide-GDP ribazoletransferase
- Cobalamin biosynthesis protein CbiB
- Adenosylcobalamin/alpha-ribazole phosphatase
- Cobalt-precorrin-4 C
- Cobalt-precorrin-2 C
- Cobalt-precorrin-8 methylmutase
- Cobyric acid synthase
- Probable cobalt-factor III C
Sequence:
MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
Protein: PTS system lactose-specific EIICB component (EIICB-Lac) (EII-Lac) [Includes: PTS system lactose-specific EIIC component (Lactose permease IIC component); PTS system lactose-specific EIIB component (EC 2.7.1.207) (Lactose-specific phosphotransferase enzyme IIB component)] (P24400)
Organism: Lacticaseibacillus casei (Lactobacillus casei)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LacEF PTS system is involved in lactose transport.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00428, ECO:0000305|PubMed:2125053}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00428}.
Interaction partners:
- PTS system lactose-specific EIIA component
- 6-phospho-beta-galactosidase
- Transcription antiterminator LacT
- PTS lactose transporter subunit IIA
- PTS mannose transporter subunit IIA
- PTS cellobiose transporter subunit IIA
- PTS cellobiose transporter subunit IIA
- PTS cellobiose transporter subunit IIA
- Galactose-6-phosphate isomerase
- Galactose-6-phosphate isomerase
Sequence:
MNKVFDKLKPVFEAIAANKYISAIRDGFIACMPIIIFSSIFMMVAYVPNAWGFYWPDNVTNTLMVAYNYSMGLLALFVAGTTAKNLTDSKNLELPKTNQINPVAVIVASEISFVILSILPLKTGVDLTYMGTQGLICAYIVGLIVPNIYYVCIKNNVTIKLPEQVPGNIAQSFKDLIPMGLSVTAFWLFGVGFKAATGTVLPRWIIQVLSPLFQASDSYLGLALIAGAMAFFWFCGVQGPSIVQPAVVPIMIANTAANLQQYQAGQHVSHVLAMNTMDYVMNFGGTGATLVVPFIMLFAARSAQLKAVGKAAFVPCTFGVNEPVLFGMPIIMNPMLFIPFLATPIVNVCLFKFFVSVLGMNSMMYTMPWTVPGPIGILISTGFAPLAFVFVLLTLVLDVAIYFPFIRVYDSTLLAEEKAKEEVIEDDGMAVLASDTVSPSIPTGLTVATATDDDATHVLPETAPSAHGEAYFKQNEVDVLVLCAGGGTSGILANALNKLSKERGLKLSAAARAYGQDMDLIKDMNMVILAPQMESMKGNLKKITDKYGVKLVTTTGRQYIELTNNGDMALDFVESNL
Protein: Tabersonine 6,7-epoxidase isoform 1 (EC 1.14.14.-) (Cytochrome P450 71D521) (A0A343URW6)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of the monoterpenoid indole alkaloids (MIAs, e.g. echitovenine, tabersonine, lochnericine, 19-hydroxytabersonine and horhammericine) biosynthetic pathway; MIAs are used in cancer treatment and other medical applications. Cytochrome P450 catalyzing the conversion of tabersonine to lochnericine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29934299}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEFVVSLFAFVVSCFILLKVAKNSKNPKRNTNLELPPGPKQLPIIGNLHQLGGGLAHHVLRNLGKQYGPLMHLKIGELSTIVVSSTEIAKEVFKTHDIHFSNRPSHILVFKIVSYDYKDIVLSQYGKYWRELRKVCNLELLSPNRVQSFRSIREDAVLNMMKSISSNDGKVVNLSEMILSLIYGITARAAFGVWSKKHEEFIRLESEIQRLATTFVLADMFPSIKFLGALSGLRYKVEKVHKKVDDILEGILKEHRRQNNNMTEENGKKDLVDVLLNIQKNGDMETPFTDQHIKAIIFDMFSAGTLTSTIAVDWAMAEMMKNPSVLKRAQDEVRNVYNGIGNVDESKLDELKYLQAVIKETLRIHPGTPIVHRETREECEINGYRIPAKARVMVNAWAISRDPNYWPEPDIFKPERFLGSEVDFKGTHFEYIPFGAGRRICPGISYAIANVQLPLAQLLYHFEWKLPGGMKPEELDMTEILGTAAQRKENLLLIPNSHSCSSLKQV
Protein: Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (O35431)
Organism: Rattus norvegicus (Rat)
Function: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Interaction partners:
- Amyloid-beta precursor protein
- Syntaxin-binding protein 1
- Peripheral plasma membrane protein CASK
- Peripheral plasma membrane protein CASK
- General receptor for phosphoinositides 1-associated scaffold protein
- Calsyntenin-1
- Neurexin-1
- Syntaxin-1A
Sequence:
MAHRKRQSTASSMLDHRARPGPIPHDQEPENEDTELPLESYVPTGLELGTLRPDSPTPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGVTYYIRYCPEDDSYLEGMDCNGEEYLAHGAHPVDTDECQEAVEDWTDSVGPHTHSHGAENSQEYPDSHLPIPEDDPTVLEVHDQEEDGHYCPSKESYQDYYPPETNGNTGGASPYRMRRGDGDLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGDSTEACSPSDTGRGPSRQEARPKSLNLPPEVKHSGDPQRGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDLNGPTDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI
Protein: Hereditary hemochromatosis protein (HLA-H) (Q30201)
Organism: Homo sapiens (Human)
Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9465039}; Single-pass type I membrane protein {ECO:0000305|PubMed:8696333}.
Interaction partners:
- Transferrin receptor protein 2
- Transferrin receptor protein 1
- Beta-2-microglobulin
- Hemojuvelin
- Hepcidin
- Transmembrane protease serine 6
- Ferroportin
- Plasma membrane ascorbate-dependent reductase CYBRD1
- Bone morphogenetic protein 6
- Natural resistance-associated macrophage protein 2
Sequence:
MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
Protein: Suppressor-of-stellate-like protein (Su(ste)-like) (Suste-like protein) (Q24536)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Casein kinase II subunit alpha
- CG13581 testes protein
- Segment polarity protein dishevelled
- Caldesmon-related protein
- Proteasome subunit alpha type-7-1B
- Uncharacterized protein, isoform A
- Uncharacterized protein, isoform A
- Venom allergen-1
- Casein kinase II subunit beta'
Sequence:
MSCPRSIEIPDGSWIDWFLGIKGHEFSCRVPNEYIQDKFNLTGLEFDSQTLEVVLDPEFDNEDWDCAEEKKLYGMIHARYIVSPRGIEDMRLKYERGDFGSCPRVFCKRQKVLPVGLHDVWDKAQVKIYCPSCNNVYIPLPHNGMLDGAMFGTSFPHMFFMQLPSLIPSPPVEKYIPRIYGFQLHKKALMPPESAESPPIKVESSVSKSPSWLRNVPNF
Protein: Fructose dehydrogenase cytochrome subunit (Fructose dehydrogenase subunit II) (M1V1V5)
Organism: Gluconobacter japonicus
Function: Cytochrome subunit of fructose dehydrogenase, an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D-fructose. In the complex, mediates both the electron transfer to ubiquinone and the anchoring of the complex to the membrane.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRYFRPLSATAMTTVLLLAGTNVRAQPTEPTPASAHRPSISRGHYLAIAADCAACHTNGRDGQFLAGGYAISSPMGNIYSTNITPSKTHGIGNYTLEQFSKALRHGIRADGAQLYPAMPYDAYNRLTDEDVKSLYAYIMTEVKPVDAPSPKTQLPFPFSIRASLGIWKIAARIEGKPYVFDHTHNDDWNRGRYLVDELAHCGECHTPRNFLLAPNQSAYLAGADIGSWRAPNITNAPQSGIGSWSDQDLFQYLKTGKTAHARAAGPMAEAIEHSLQYLPDADISAIVTYLRSVPAKAESGQTVANFEHAGRPSSYSVANANSRRSNSTLTKTTDGAALYEAVCASCHQSDGKGSKDGYYPSLVGNTTTGQLNPNDLIASILYGVDRTTDNHEILMPAFGPDSLVQPLTDEQIATIADYVLSHFGNAQATVSADAVKQVRAGGKQVPLAKLASPGVMLLLGTGGILGAILVVAGLWWLISRRKKRSA
Protein: Protein OCTOPUS-like (AtOPSL1) (Q9LFB9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potentiates primary root protophloem differentiation. Regulates roots architecture.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9SS80}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9SS80}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9SS80}. Cytoplasm {ECO:0000250|UniProtKB:Q9SS80}.
Interaction partners:
- At1g56580/F25P12_18
- Regulatory-associated protein of TOR 2
- Uncharacterized protein T9C5.90
Sequence:
MNLSADQAPVTAVDELAPPSQPHRLSTSCDLHPEERFSGFCPSCLCDRLSVLDHNAAPPPSSSSRKPPSISAVSLKALFKPSSSGTNNSNGNGRVRPGFFPELRRTKSFSAKNNEGFSGGFEPQRRSCDVRLRDDERNLPINEAASVDKIEEEARESSVSEIVLEVTEEAEIEEDEENGEKDPGEIVEEKSSEIGEEEEELKPMKDYMDLYSQTKKPSVKDFAGSFFSAASVFSKKLQKWKQKQKVKKPRNGVGGGRPQSEIGVGRRSSDTDPRFSLDAGRFSVDIGRISMDDSRYSLDEPRASWDGHLIGRTTAARVPLPPSMLSVVENAPLNRSDMQIPSSPSIKPISGDSDPIIIIPGGSNQTRDYYTGPPSSRRRKSLDRSNSIRKIVTELEDVKSVSNSTTTIDSNSMETAENKGNQNGDKKSRRWGKWSILGFIYRKGKDDEEEDRYSRSNSAGMVERSLSESWPEMRNGEGGGPKMRRSNSNVSWRSSGGGSARNKSSRYSSKDGENGMLRFYLTPMRRSWKTSGGSGGGGGGGGGGGWEKTAAKANSHGHSIARRVMRLY