wanglab/gogpt-training-data huggingface dataset:
Protein: Sulfate transporter 1.2 (Q9MAX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity H(+)/sulfate cotransporter that mediates the uptake of the environmental sulfate by plant roots. Plays a central role in the regulation of sulfate assimilation. Unable to transport molybdate.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- 5'-adenylylsulfate reductase 3, chloroplastic
- Cysteine synthase 1
- Pentatricopeptide repeat-containing protein At4g18520, chloroplastic
- 5'-adenylylsulfate reductase 2, chloroplastic
- Putative inactive cysteine synthase 2
- 5'-adenylylsulfate reductase 1, chloroplastic
- Bifunctional cystathionine gamma-lyase/cysteine synthase
- Assimilatory sulfite reductase
- Protein RESPONSE TO LOW SULFUR 1
- Beta-glucosidase 28
Sequence:
MSSRAHPVDGSPATDGGHVPMKPSPTRHKVGIPPKQNMFKDFMYTFKETFFHDDPLRDFKDQPKSKQFMLGLQSVFPVFDWGRNYTFKKFRGDLISGLTIASLCIPQDIGYAKLANLDPKYGLYSSFVPPLVYACMGSSRDIAIGPVAVVSLLLGTLLRAEIDPNTSPDEYLRLAFTATFFAGITEAALGFFRLGFLIDFLSHAAVVGFMGGAAITIALQQLKGFLGIKKFTKKTDIISVLESVFKAAHHGWNWQTILIGASFLTFLLTSKIIGKKSKKLFWVPAIAPLISVIVSTFFVYITRADKQGVQIVKHLDQGINPSSFHLIYFTGDNLAKGIRIGVVAGMVALTEAVAIGRTFAAMKDYQIDGNKEMVALGMMNVVGSMSSCYVATGSFSRSAVNFMAGCQTAVSNIIMSIVVLLTLLFLTPLFKYTPNAILAAIIINAVIPLIDIQAAILIFKVDKLDFIACIGAFFGVIFVSVEIGLLIAVSISFAKILLQVTRPRTAVLGNIPRTSVYRNIQQYPEATMVPGVLTIRVDSAIYFSNSNYVRERIQRWLHEEEEKVKAASLPRIQFLIIEMSPVTDIDTSGIHALEDLYKSLQKRDIQLILANPGPLVIGKLHLSHFADMLGQDNIYLTVADAVEACCPKLSNEV
Protein: COMM domain-containing protein 6 (Q7Z4G1)
Organism: Homo sapiens (Human)
Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:21778237}. Cytoplasm {ECO:0000269|PubMed:16573520}.
Interaction partners:
- COMM domain-containing protein 9
- COMM domain-containing protein 1
- COMM domain-containing protein 10
- Coiled-coil domain-containing protein 22
- COMM domain-containing protein 3
- COMM domain-containing protein 2
- COMM domain-containing protein 4
- Coiled-coil domain-containing protein 93
- COMM domain-containing protein 8
- COMM domain-containing protein 7
Sequence:
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV
Protein: Desmoglein-2.1 (H2EQR6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). Required for embryogenesis, specifically for progression of epiboly and normal convergence-extension movements during gastrulation.
Subcellular location: Cell junction, desmosome {ECO:0000250|UniProtKB:Q14126}. Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q14126}.
Interaction partners:
Sequence:
MARRISPVVAFLLCFGLSHFFEAEARLQHSVALHRQKREWIVPPQILEENVDYTKKDFIAKIRSDKEVAHMKYLRYSLRGVGADQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIALFTDGSIAENDIGLRIKVKDQNDNAPVFGVMNPGAVDELSAVGTEVMRLNCFDADEPGNPNSQIKYEIVDQQPAGQSMFTVENNRRVVVANPNLDRETVDQYVLLVKASDLNGAPGGNAATGTVTIKINDVNDNVPTLGGPYEASIEENTEKVEVMRLKVSDLHLKGTDNWEGDCYIASGNEAGYFSIHMDPKTNEAVLMLDKAVDYEDVKDLNLGIGVANKAPFHPSVSGGSQGATISFGGSGGGAGSGAAGGAGAMGGASGSGGGTGASSWSSSGVPLYNVNIKVKNQPEGPKFFPGTKAIPISEGKAFDSTEIIARYPAIDTDTGKEATNVKYIKSSDPDNWLTIDEKTGAIRMNKAPDRESKYLVNGTYYAKVLSITQDLPSKTATGTIAIQVEDFNDHCPTLISNVQTLCTDKDAVLVTAKDEDAPPNGAPFDFNIVSEGTAGKWTVEYMNDTTAIFRTHEKLWPGPHELMVEVTDQQGLKCPEPQKLQVDVCTCKNQGGCDRTATGDAKKGSRLGPAGIGLLLLALLALLLIPLLLLLCTCGMTGAFTDMPFETKVHLISSNTEGQGEDRDVPLMCPPSNVDGMGFMTKDYMAVGAMHSAGLGLGVGAGVGAAGFLESTSTMGGRGYNEMELDYMNSIGRNNAYSSRDMAGDFDGMALSDGYLCEYYSQKSRVVDGFGKDDPMVYDYEGKGSPVGSVGCCSLLEDQNDLEFLNDLGPKFTTLADICGGKKTEIPAPAPAPLPPPPKPVVDRSEVVSSTTNILNTGNIATNRVNTVNVASNMATASSTRVENVLVTDNRPTMITSVHPAPTLLVQPQPMYYMVEQQPSTVLVAERPAMTQGMYVLNSGPVAEGMVVQGGNIAANTLTRGERMVLVFRGGPAQALNNGMLHTSNLSGSQLLLVDGGATSGQVLQGTIQRGVAGSQGLMFVDGQGGQVIQGSINNGISTHGGSQNVFYVENKGGSSVVQGGLQMGKASTAGSLIGDVGIGGSSVKITQNPSSHKVVVQERKVVTTQSVK
Protein: Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) (O75382)
Organism: Homo sapiens (Human)
Function: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36481767}. Early endosome {ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:32878999}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:32878999}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1R2}. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000269|PubMed:32878999}.
Interaction partners:
- Alpha-actinin-4
- Unconventional myosin-Va
- Kinesin-like protein KIF21B
- Importin subunit alpha-3
- Gamma-butyrobetaine dioxygenase
- Tripartite motif-containing protein 2
Sequence:
MAKREDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAYRYLQ
Protein: Farnesoate epoxidase (EC 1.14.14.128) (Cytochrome P450 15C1) (Protein dimolting) (mod) (C0SPF7)
Organism: Bombyx mori (Silk moth)
Function: Catalyzes the conversion of farnesoate to juvenile hormone III acid in juvenile hormone biosynthesis.
Interaction partners:
- Juvenile hormone acid O-methyltransferase
- Epoxide hydrolase
- Aldedh domain-containing protein
- Juvenile hormone epoxide hydrolase
- Mitochondrial aldehyde dehydrogenase
- Epoxide hydrolase
- Aldedh domain-containing protein
- Glutathione peroxidase
- Methyltransf_25 domain-containing protein.
- Methyltranfer_dom domain-containing protein.
Sequence:
MLALIVLCFILFFYIISRRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIREVSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGDECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKELCSLVMRLFKLVDMSGGFLNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKPTLDDLQVVCLDLLEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNPLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYELHHGPHWKDPETFRPERFLTKEGNILQDEWLIPFGIGKRRCIGEGLARSELFMFLTHILQKFHLRIPKNEPLPSTEPIDGLSLSAKQFRIIFEPRKTFKSI
Protein: MLP-like protein 423 (Q93VR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nucleic-acid protein
- Uncharacterized protein
- Cotton fiber protein
- AT4g23680/F9D16_150
Sequence:
MGLSGVLHVEVEVKSPAEKFWVALGDGINLFPKAFPNDYKTIQVLAGDGNAPGSIRLITYGEGSPLVKISAERIEAVDLENKSMSYSIIGGEMLEYYKTFKGTITVIPKDGGSLLKWSGEFEKTAHEIDDPHVIKDFAVKNFKEIDEYLLKQTSA
Protein: Protein-arginine N-acetylglucosaminyltransferase SseK2 (Arginine GlcNAcyltransferase SseK2) (EC 2.4.1.-) (Salmonella secreted effector K2) (P0DUJ8)
Organism: Salmonella typhimurium (strain SL1344)
Function: Protein-arginine N-acetylglucosaminyltransferase effector that catalyzes the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins such as FADD: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host small Rab1 GTPase, thereby preventing GTPase activity and leading to impaired host vesicular protein transport. In contrast to Ssek1, not able to disrupt TNF signaling in infected cells (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8ZNP4}. Host Golgi apparatus {ECO:0000269|PubMed:32432056, ECO:0000269|PubMed:32974215}. Note=Secreted via the type III secretion system (T3SS). {ECO:0000250|UniProtKB:Q8ZNP4}.
Interaction partners:
Sequence:
MARFNAAFTRIKIMFSRIRGLISCQSNTQTIAPTLSPPSSGHVSFAGIDYPLLPLNHQTPLVFQWFERNPDRFGQNEIPIINTQKNPYLNNIINAAIIEKERIIGIFVDGDFSKGQRKALGKLEQNYRNIKVIYNSDLNYSMYDKKLTTIYLENITKLEAQSASERDEVLLNGVKKSLEDVLKNNPEETLISSHNKDKGHLWFDFYRNLFLLKGSDAFLEAGKPGCHHLQPGGGCIYLDADMLLTDKLGTLYLPDGIAIHVSRKDNHVSLENGIIAVNRSEHPALIKGLEIMHSKPYGDPYNDWLSKGLRHYFDGSHIQDYDAFCDFIEFKHENIIMNTSSLTASSWR
Protein: Importin subunit alpha (Q8IAW0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Karyopherin beta
- Ran-specific GTPase-activating protein 1, putative
- Importin alpha re-exporter, putative
- Importin subunit beta, putative
- Sentrin-specific protease 1
- MORN repeat protein
- Nuclear cap-binding protein subunit 2
- Exosome complex exonuclease RRP6
- Ribosomal RNA-processing protein 8
- Nucleoporin NUP221, putative
Sequence:
MDRRIEARRKEFKKNCDDTRRKREDLVVQIRKQQRECQLESKRAMVMANIGFEENNTYNLNYAKGNQNDSTNDSIYNTSSNNSSNTLEMLKKIPTLAIGVRSNEYVTQLNSTRELRKLLSIEKGPPIQEVINSGVVPYIVEFLKYDDKTDLQFEAAWVITNIASGSQEQTKVVIDNNAVPHLVRLLSSEKEDVCEQAVWALGNIAGDSAECREYVLNQNSLPLLLKILRTSHKRTLIRNAAWTLSNLCRGKPAPKFEIVSKALPTLAALIYNDDEEILTDACWTLSYLSDGSNENINSVLDAGVAERVVELLSHCSFLVQTPALRTVGNIVTGDDLQTDVVVKLGAVQKLSCLLNSSKKSIKKEACWALSNITAGNISQIQAVIDNNVIPQLINILMKEDFEVRKEAAWAISNASSGGSELQIEYLVECGAIHSLSNLLDVEDANIISVTLEGLENILEMGENKKLRDNLPTNPYVHLFEECDSVHKIDALQDRKVDNICNKAWKILYKYFPFVINNELNNAQIPLNNVFANTEDAVLNKDFTFD
Protein: NifU protein (P74558)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- cysteine desulfurase
- Putative pyruvate-flavodoxin oxidoreductase
- cysteine desulfurase
- Uncharacterized isomerase slr1019
Sequence:
MELTLNNVETVLDELRPYLMADGGNVEVVELDGPIVKVRLQGACGSCPSSTMTLKMGIERKLREMIPEIAEVEQVL
Protein: MGC174857 protein (Si:dkey-26g8.5) (Uncharacterized protein LOC563390 precursor) (Uncharacterized protein isoform X1) (A7MCR8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cathepsin D
- Napsin A aspartic peptidase
- Apoptosis regulator Bcl-2
- BH3-interacting domain death agonist
- Baculoviral IAP repeat-containing 5b.
Sequence:
MMFALLVTLCISAVFTAPSIDIQLDDHWNSWKSQHGKSYHEDLEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGIMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPRGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM
Protein: ETS translocation variant 1 (Ets-related protein 81) (P50549)
Organism: Homo sapiens (Human)
Function: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Transmembrane protease serine 2
- E3 ubiquitin-protein ligase COP1
- Solute carrier family 45 member 3
- Androgen receptor
- RNA-binding protein EWS
- DET1 homolog
- Serine/threonine-protein kinase 40
- Double homeobox protein 4-like protein 2
- Mast/stem cell growth factor receptor Kit
- RNA-binding protein FUS
Sequence:
MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A2A122)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSRNIEWEHFEEREKGHRSPRGSGGSHSGSRGNGIVPSPAHSAHCSFYRTRTLQSLTSEKKAKKVRFYRNGDKYFKGLVYAVSGDRFRSFDALLMELTRSLSDNVNLPQGVRSIYTADGGKKITSLDDLVEGESYVCASNEPFRKVDYTKNVNPNWSVNVKTGASRSMPSLTATKNELRERESKDYIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGAVKRLYTLEGKQIICLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSGKASTAFITECQVIKSSYSARSAPPVRYSGSKSPGTGRRSKSPGSVNGAPNSQITTPKSAKSSSSSPTSPRSMRNFKIPTHHSSAGNVNGSSETPQHHNNSLSPEVNGNRNLAASTILDKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMNTALDKETIQLSHRRQDRNPPRPEKRPSSTNPERRRSNRGRSSVQSEDSRSAAPIEPATSANPSAPAALPSDPSPQFHECNTESEASKDLLKEE
Protein: Lectin29Ca (Q6GUX3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYKYATCIFSIFALWNFWGVSAKKQDTSTGTNELPKAPMPYYTIENIDMHQQHWLTYNSLRQNGTLWRIGNMEQRLEMRLQSFQNQMETKLRALKQQIEPYMENVKMSNKIKMSVFKKIGSRHFYLEKQKKMPWDSAYDTCRQMGGHLANILDEKELNEIFSEETKKKYWVDINSRANDGASWISTLSGRDVPFLKWKPNLATNIHNHCVYINSNEMYFENCANDNYFACQAEQWA
Protein: Inwardly rectifying potassium channel 3, isoform D (B7YZX2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
Interaction partners:
- ATP-binding cassette sub-family C member Sur
- Uncharacterized protein
Sequence:
MQSDASPLGAAATDSLTMHRSTSMPVKPKPLEQKPLLRSSEKETVNASDYYPESPGFVRRRRSKAAGDHLETRSEQNPTFSFPYAHDWAGSTIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIKSHVELKLEGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPMTNPKNDHLKLEYRK
Protein: Caffeine dehydrogenase subunit gamma (EC 1.17.5.2) (Caffeine dehydrogenase small subunit) (D7REY5)
Organism: Pseudomonas sp. (strain CBB1)
Function: Catalyzes the hydrolitical oxidation of 1,3,7-trimethylxanthine (caffeine) by incorporation of an oxygen atom originating from a water molecule into position C-8 to produce 1,3,7-trimethyluric acid (TMU). Coenzyme Q0 is the preferred electron acceptor and coenzyme Q2 can also be used, but oxygen and NADP cannot.
Interaction partners:
Sequence:
MSSHVISLTVNGQAIERKVDSRTLLADFLRDELRLTGTHVGCEHGVCGACTIQFDGEPARSCLMLAVQAEGHSIRTVEALAVDGCLGALQQAFHEKHGLQCGFCTPGLLMTLDYALTADLHIDFSSDKEIRELISGNLCRCTGYQNIINAIKSVSPTTEIAKSEELV
Protein: Serine/threonine-protein kinase PknD (EC 2.7.11.1) (P9WI79)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of a signaling pathway that enables adaptation to osmotic stress through cell wall remodeling and virulence factor production. Phosphorylates the osmosensory protein OprA, which inhibits binding of OprA to Rv2638, leading to the regulation of osmotically regulated genes, including the ESX-1-associated virulence factor espA. In addition, directly phosphorylates the alternative sigma factor SigF and its regulator, Rv1364c, which regulates the SigF-Rv1364c interaction. Can also phosphorylate the FHA domain of Rv1747.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Serine/threonine protein phosphatase PstP
- Phosphate-binding protein PstS 2
- ABC transporter ATP-binding/permease protein Rv1747
- Uncharacterized protein
- Glycogen accumulation regulator GarA
- FHA domain-containing protein FhaA
- cAMP/cGMP dual specificity phosphodiesterase Rv0805
Sequence:
MSDAVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKLISPQYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGTSLRALLKQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTASDFAYLVDFGIARAASDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIYALACVLGECLTGAPPYRADSVERLIAAHLMDPAPQPSQLRPGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDALTTSEQHQATTILRRGDNATLLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLAADSRGGNWPSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVAIVAAAGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGSTGTTVLPFNGLYQPQGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAVDTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVVKLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGLNTPLAVAVDSDRTVYVADRGNDRVVKLTS
Protein: Cruzioseptin-15 (CZS-15) (C0HK11)
Organism: Cruziohyla calcarifer (Splendid leaf frog) (Agalychnis calcarifer)
Function: Has antimicrobial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:27321580}.
Interaction partners:
Sequence:
GFLDIVKGVGLVALGAVSKS
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (H7C270)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQPPHWPAPQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
Protein: DnaJ homolog subfamily C member 2 (Mouse Id associate 1) (MIDA1) (Zuotin-related factor 1) (P54103)
Organism: Mus musculus (Mouse)
Function: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:8666407}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q99543}.
Interaction partners:
- Heat shock 70 kDa protein 14
- Heat shock 70 kDa protein 1B
- Zinc finger protein ZPR1
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 1-like
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 1A
- Heat shock-related 70 kDa protein 2
- Zinc finger CCCH domain-containing protein 15
- Stress-70 protein, mitochondrial
Sequence:
MLLLPSAAEGQGTAITHALTSASSVCQVEPVGRWFEAFVKRRNRNASTSFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYTATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFQVFSPVFERNSRWSNKKNVPKLGDMNSSFEDVDAFYSFWYNFDSWREFSYLDEEEKEKAECRDERKWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEARRKEQEAKEKQRQAELEAVRLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKSWNHFSDNEADRVKMMEEVEKLCDRLELASLQGLNEILASSTREVGKAALEKQIEEVNEQMRREKEEADARMRQASKNAEKSTGGSGSGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVISKAKSLQKLDPHQKDDINKKAFDKFKKEHGVASQADSAAPSERFEGPCIDSTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMRRYKELVEMVKAKKAAQEQVLNASRARK
Protein: DNA packaging protein (ORF 25) (ORF25) (Q6QCN0)
Organism: Human herpesvirus 3 (HHV-3) (Varicella-zoster virus)
Interaction partners:
Sequence:
MYESENASEHHPELEDVFSENTGDSNPSMGSSDSTRSISGMRARDLITDTDVNLLNIDALESKYFPADSTFTLSVWFENLIPPEIEAILPTTDAQLNYISFTSRLASVLKHKESNDSEKSAYVVPCEHSASVTRRRERFAGVMAKFLDLHEILKDA
Protein: Gli2 protein (Q0VGV1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAAVAAHGVPQQLLPAFHAPLPIDMRHQEGRYHYDPHSVHSVHGPPTLSGSPFISDISLIRLSPHPAGPGESPFSAHHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMASHPTPYGDLLMQSGGAASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMTLTSISTMPTQLSSSSSNCLNDANQNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLTQEQLADLKEDLDRDDCKQEAEGVIYETNCHWADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHVRAPLLKENGDNEASAEPGGRGPEESVEASSTSHTVEDCLHIKAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGMEMPGTGPGSLGDLTALADTCPGADTSALAAPSTGGLQLRKHMSTVHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTGGGGPAGLLPSQRLPELTEVTMLSQLQERRDSSTSTMSSAYTVSRRSSGISPYFSSRRSSEASPLGGLRPHNASSADSYDPISTDASRRSSEASQCSGGGPGLLNLTPAQQYNLRAKYAAATGGPPPTPLPGLDRVSLRTRLALLDAPERALPGACPHPLGPRRGSDGPTYSHGHGHGYAGAAPAFPHEGPNSSTRRASDPVRRPDPLILPRVQRFHSTHNMNPGSLPPCADRRGLHVQSHPSVDSNLTRNAYSPRPPSINENVVMEAVAAGVDGPGLECDLGLVEDELVLPDDVVQYIKAHTGGTLDDGIRQGYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLNKSNMPVQWNEVSSGTVDALPTQVKPPPFPHSNLAVVQQKPAFGQYPGYNPQSVQSSSGGLDSTQPHLQLRGAPSASRGSYTQQPRQPAAGSQCLGMSAAMSPQASYSQAHPQLSPNIVSGSLNQFSPSCSNMAAKPSHLGLPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPVLSYPQQDSYQQGSNLLSSHQPGFMESQQNAGFGLMQPRPPLEPNTASRHRGVRSGQQQLYARTTGQAMVTSANQETAEAMPKGPAGTMVSLAPQPSQDTGRAQDQNTLYYYGQIHMYEQNGGCPAVQPQPPQPQACSDSIQPEPLPSPGVNQVSSTVDSQLLEPPQIDFDAIMDDGDHSSLFSGALSPTLLHNLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFF
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (Q9YIC3)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MPRRGVGCGALLLLPALLVSWAACQAPPVPAAEPPWDGADVHVERRFVPERLPRAVRRGDFVRYHYLGSFPDGTRFDSSYDRGSTFNVFVGKGQLIAGMDKALVGMCVNERRFVKIPPKLAYGSEGVSGVIPPNAVLHFDVLLIDLWNSEDEVQVETYFKPEKCTRRVQVSDFVRYHYNGTFLDGTLFDSSHNRMRTYDTYVGIGWLIPGMDQGLLGMCIGEKRIITIPPFLAYGEEGDGKEIPGQASLVFDVVLLDLHNPKDGITIENQLVPESCERRTQTGDFIRYHYNGTLLDGTLFDSSYSRNRTYDTYVGKGYVIAGMDEGLLGVCTGERRRIIIPPHLGYGEEGRGKIPGSAVLVFDIHVADFHNPSDSVSITVNYKPSNCSLLSKKGDYLKYHYNASLLGWHSASLDTQSWQDLQHSSGSGQVVIGMDMGLQDMCVGERRTVVIPPHLGYGEDGVEGEVPGSAVLVFDIELLELVSGLPEGYMFVWNGEVSPNLFEEIDQNHDGEVLLEEFSEYIQAQVDSGKGKLAPGFDFEKIVKNMFTNQDRDGNGKVTAEEFKLKDQEAKEGHDEL
Protein: Leucine-rich repeat-containing 32 (Transforming growth factor beta activator LRRC32) (E7FFN8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Discoidin, CUB and LCCL domain-containing 2.
- Transforming growth factor beta
- Transforming growth factor beta
- Leucine-rich repeat-containing 31.
- Mediator of RNA polymerase II transcription subunit 22
Sequence:
MGTCLWILMLMVSQVSPYRRPAEDSPCRVHQDDVDCSSLSLRRVPAPLPSSIRLLDLSQNLLQNLTLQDLPSRSSLRRLDLHHNQIQFLQPGLFRDLLHLEDLDLSGNALDLYAALHTPLGPLPALRRLDLSGNGLFTDMSDYFLSDAPALTNLSLDGNSITKISRTTFNGSQALQNIDLHNNVIIEIEEGAFEFLTELSELDLSVNSISCITDFNLVQLRTLNLSRNSLTNFQSLDMEDEFQLQHLDLRENKLLYFPVLPQRNRLMYLDLSRNLLRSVNCSGPLEELESLRESGYLLTAHDKPLTLCANERQQELGRLLYLDLSFNQLKTLSSSFFSSMAALESLNISNNCLQSFSVDSLRSLKTLDLSFNNLQNLSFSGGALPALEVLLLQGNALHLLDAHIFSSLPSIRSLHLQQNLLSICADPQISSGCVHLSDIPSLTYLYLSENSLSSIPDGAFKGSPLLILDLSLNPGVDITAASLSGVETSLTHLSLRGNQLHSLSIDFRVFQKLRSLDVSVNRLSGVSPWSEDSSVEILNLQNNRVEALGSALLQGRLRTLYVGWNPLSCCRNPQLLDLLQQERLHVPDLAAATCWYSGDVEQVEVSVSAALPELCSSADSRVLWVSLMVALALGLALVLTVSLKLCHSRKHRFKRGFKA