wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor bHLH81 (Basic helix-loop-helix protein 81) (AtbHLH81) (bHLH 81) (Transcription factor EN 72) (bHLH transcription factor bHLH081) (Q9M0R0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor GLABRA 3
- Adagio protein 3
Sequence:
MQPTSVGSSGGGDDGGGRGGGGGLSRSGLSRIRSAPATWLEALLEEDEEESLKPNLGLTDLLTGNSNDLPTSRGSFEFPIPVEQGLYQQGGFHRQNSTPADFLSGSDGFIQSFGIQANYDYLSGNIDVSPGSKRSREMEALFSSPEFTSQMKGEQSSGQVPTGVSSMSDMNMENLMEDSVAFRVRAKRGCATHPRSIAERVRRTRISDRIRKLQELVPNMDKQTNTADMLEEAVEYVKVLQRQIQELTEEQKRCTCIPKEEQ
Protein: histidine kinase (EC 2.7.13.3) (Q8A2Y3)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Two-component system sensor histidine kinase/response regulator, hybrid
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MKTRLLTLPGIIAIILLITTLPLRAEHYYYKQISLKEGLPSNVRCILRDEQGFIWIGTKAGLGKFDGHQLKRYKHQANDPHSLLHNLIYQIAEDKQHNIWILTEKGIARYQQQSNNFTFPTDEEGNYITAYSFCLVPDGILFGGKDRIYKYSYKDSSLRLLQYFNANSFKITALSVWDSKTLLCCSRWTGLYLVDLQTGEHRRPPFDCGPEITSMITDSKNRIWIAPYSGGLRCYSRDGKLSASYTTHNSSLSNDIVLSLAEREEQLWIGTDGGGINILHPETGEISQLEYIPGRENYSLPANSILCLHNDYNNNVWAGSTCNGLISIREVSMKTYTDVVPGNDRGLSNGTVRSLYRQSPDSIWIGTDGGGINLFSPHTEKFTHYSSTWGDKVAFISGFTPGKLLISLFSKGVFVFNPATGEKQPFTIIDKETTTRLCNRGKSVNLYQNTPNTVLFLGDHIYQYHLKEKKFSTITEEEGKDIVGTLVPFDHQENLTYINDIKHIYELDDQTSRLKTVFECYTDTVISSVSHDEQGHFWIGSNFGLIHYDPVLKSRTLVPTNLFTEINMVLCDQKGKVWIGVDNMLFAYFIKEQKFVLFGESNGAIQNEYLPNARLVNEQGDAYIGGVKGMLRIDGQLLLNTSEMPELQLLDITINGESANHEWYNHPAKISVPWNSNISIRIMSREEDIFRQKIYRYQIEGLNNEYTESYNPELVIRSLLPGSYRIMASCTAKDGSWIPDQQVLELTVLPPWYRTWWFSLTCAVLVSIAIIETFRRTVKRNEEKLKWAMKEHEKQTYEEKVRFLINISHELRTPLTLIHAPLNRILKSLSSEDPQYLPLKAIYRQAQRMKNLINMVLDVRKMEVGESKLLIQPHPLNHWIEHVSQDFISEGEAKNVRIRYQLDPQIETVSFDKDKCEIILSNLLINALKHSPQDTEITIASELLPETGRVRISIIDQGCGLKQVDTHKLFTRFYQGTGEQSGTGIGLSYSKILVEQHGGSIGAQDNPEAGAIFFFELPLKQESEEIICQPKAYLNELILSDNLKQATDKETFDTTPYTILVVDDNPDMTDFLKKTLEESFKRVIIAADGVEALQLIKSHIPDIIVSDVMMPRMNGYELCINIKEDITISHIPIILLTARDDKQSLISGYKNGADAYLTKPFEVEMLMEIISNRLKNREYIKKRYLHTGIIPVPKETTFSQVDESFLLKVNKTIQENLSNTNLDIQFICKEIGLSRTSLYTKLKALTGIGANDYINKFRIEKALTLIANTEMTFTEISEEVGFTSPSYFSTAFKQYTGETPTQYKEKTSKI
Protein: Dolichyl-monophosphooligosaccharide--protein glycotransferase AglB (EC 2.4.99.21) (Archaeal glycosylation protein B) (Dolichyl-phosphooligosaccharide-protein glycotransferase) (Oligosaccharyl transferase) (OST) (OTase) (Oligosaccharyl transferase AglB) (D4GYH4)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (a hexose-linked tetrasaccharide composed of a hexose, 2 hexuronic acids and a methyl ester of hexuronic acid in H.volcanii) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). Involved in the assembly of an N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins (Probable).
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glucosyl-dolichyl phosphate glucuronosyltransferase
- Glycosyltransferase AglD
- Large ribosomal subunit protein eL32
- Glycosyltransferase AglJ
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL42
- Large ribosomal subunit protein uL13
- Cell surface glycoprotein
- Large ribosomal subunit protein uL30
- Signal peptidase I
Sequence:
MSDEQTKYSPSIAELARDWYHIPVLSTIILVMLWIRLRSYDAFIREGTVFFSGNDAWYHLRQVEYTVRNWPATMPFDPWTEFPFGRTAGQFGTIYDQLVATAALVVGLGSPSSDLVAKSLLVAPAVFGALTVIPTYLIGKRLGGRLGGLFGAVILMLLPGTFLQRGLVGFADHNIVEPFFMGFAVLAIMIALTVADREKPVWELVAARDLDALREPLKWSVLAGVATAIYMWSWPPGILLVGIFGLFLVLKMASDYVRGRSPEHTAFVGAISMTVTGLLMFIPIEEPGFGVTDFGFLQPLFSLGVALGAVFLAALARWWESNDVDERYYPAVVGGTMLVGIVLFSLVLPSVFDSIARNFLRTVGFSAGAATRTISEAQPFLAANVLQSNGQTAVGRIMSEYGFTFFTGALAAVWLVAKPLVKGGNSRKIGYAVGSLALIGVLFLIPALPAGIGSALGVEPSLVSLTIVTALIVGAVMQADYESERLFVLVWAAIITSAAFTQVRFNYYLAVVVAVMNAYLLREALGIDFVGLANVERFDDISYGQVAAVVIAVLLILTPVLIIPIQLGNGGVSQTAMQASQTGPGTVTQWDGSLTWMQNNTPAEGEFGGESNRMEYYGTYEYTDDFDYPDGAYGVMSWWDYGHWITVLGERIPNANPFQGGATEAANYLLAEDEQQAESVLTSMGDDGEGDQTRYVMVDWQMASTDAKFSAPTVFYDESNISRSDFYNPMFRLQEQGEQTTVAAASSLKDQRYYESLMVRLYAYHGSAREASPIVVDWEERTSADGSTTFRVTPSDGQAVRTFDNMSAAEEYVANDPTSQIGGIGTFPEERVSALEHYRLVKSSNSSALRSGSYQRSLISEGNTYGLQPQALVPNNPAWVKTFERVPGATVDGSGAPANTTVTARVQMRDLTTGTNFTYTQQAQTDADGEFTMTLPYSTTGYDEYGPDNGYTNVSVRAAGGYAFTGPTSVTGNSTIVSYQAENVAVDEGLVNGAEDGTVQVTLERNEQELDLPGDSSSEDSSSEDGTSDGSQTNESASTSTSASVDASAVSAAA
Protein: Ubinuclein-1 (Ubiquitously expressed nuclear protein) (Q4G0F8)
Organism: Mus musculus (Mouse)
Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cell junction, tight junction {ECO:0000269|PubMed:18823282}. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis (By similarity). Colocalizes with TJP1. {ECO:0000250}.
Interaction partners:
- Calcineurin-binding protein cabin-1
- Histone chaperone ASF1A
- Protein HIRA
- Histone chaperone ASF1B
- Transcriptional regulator ATRX
Sequence:
MSEPHRVQFTSVPGSLNPAFLKKSRKEEVGGTEQHQDCEPAAAAVRITLTLFEPDHKRCPEFFYPELVKNIRGKVKGLHPGDKKKDVLDPFNDEEKERHKVEALARKFEEKYGGKKRRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFIKEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYSGSLSVREMLKKFQKEKEAQKKREEEHKPVAVSSIEAQGLRELEGTSDPLLSLFGSTSDNDLLQAATAMDSLTDLDLEQLLSESPEGSPFRDMDDGSDSLGVGLDQEFRQPSSFPEGLPIPLEKRVKELAQAARAAEGESKQKFFTQDINGILLDIEVQTRELTSQIRSGVFAYLASFLPCSKDALVKRARKLHLYEQGGRLKEPLQKLKDAIGRAMPEQVAKYQDECQAHTQAKVAKMLEEEKDKEQRERICSDEEEDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESRDLERNSKAQAWEDCVKAFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSLLAKKKVIAPSKIKMKESSVKLDKKVSVPSGQHGGPTTLLSEHQGGGLNTGANSREHPSQATCGLTDSVSVTLEDSLDEDLVRNPASSVDAVSKELATLNSRAANSSEFTLPTPSKAPTEKVGGVLCTEEKRNFAKPSSSAPPPTNALQSPLNFLAEQALALGQSSQEKKPEGSGFKELSCQGPLSKGVPELHPSKAKHHNLPRTSHGPQAAAPVPGPQVKVFHAGTQQQKSFTPPSPFVNKLQGPKATSPQCHRSLLQLVKTAAKGQAFHATMPASSGSSPASSSSAHKTTASNSTTISHPAKLHPTSSVGPSYKNNPFAGSVSKHGASSSSPSPGGGAQVQSSVSGASLPGVQSPSAGQSASRAAPSSAVKKTPVTQKLTLVAPPGGPNGDSGGGTQGVAKLLTSSLKPAAVSSVTSSTSLPKGTGGAVLLSNTSSLSLLSSSYKSNNPKLPGAMNSNSLGIITQFPLHVLSFNADSSAKAGVSKDAIVTGPAPGTFHHGLSHSLLAGLHSSPPHTAPLPHAAVSTHVPQSLPDASQLHGKGPVVPRKL
Protein: TPR repeat-containing protein ZIP4 (Protein ZIP4 homolog) (OsZIP4) (Q5N829)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover) and works cooperatively with MER3 to promote crossovers.
Subcellular location: Nucleus {ECO:0000269|PubMed:22393242}. Chromosome {ECO:0000269|PubMed:22393242}. Note=Detected in punctuate foci onto the chromosomes in prophase I meiocytes. {ECO:0000269|PubMed:22393242}.
Interaction partners:
Sequence:
MKISELSPEYREPPSHAGLIADLSKAVSDVESFAASATAPEKLAADLRRILTSLASAASSSSFTESLSVQIWRLGTRLWNAVVDRANSAALAGGPAALAVEAEIRQAAPELLLLAGIPNGVPSAAAKVASFFHRSGLAWLDLGRVDLASACFEKATPLVSAAATEDRGVLLELNLARARAASDAGDQALAVALLSRSKPLAAASPEGAKSLAQGYLSIGEATLAAKHSNPAVEASTLFTEALDLCEKAASPSSSSPRTPPYGGATPKTPNLEGLKRRCLRFLALERLQAQDYEGVLRCIRVSRASMGLEEEHPSIGVMAMRAWIGSGNMAEADKELERLMANALATENLCVSAAEAYLAAAGPEAARKVLIALAARCRAGGAAAAVRVVKQVIDGGGGGIGRARAIAELVSDERVVALFDGPGNTHERGTMHALLWNCGTEHFRAKNYDTSADLIERSMLYVSRDEESRSRRADCFRVLSICHIALQHLDRALEFVNEAYKVEPNIKCAFLKVKINLQKGEEDEAFKQMKTMVGCVDFNPEFLTLTAHEAMSCKSFGVAVASLSYLLGLYSAERPMPMPEVAVLRNLIELLSREPGTEAEILKYSRRAKQRMADLGVESFFGSGIVGGRELNWFADLSWNMGLRASKEKKYNFGAEFFELAAEFFSSRNAECDENRSKVCKALIMAVTIMLNAEELNNSPLSDSDIKKGVEMLSRAGKLLPLISPSVPVASDQLEANNFLYLHTFNSYQLMGRMGTPAHPQQLQLIKNFASSKACTPANLLTLGVTASKGALPNMLAAEFSLKACITTALASQSPNYRVISCALRKLACLAGLQDLNGSKSDAAYDVFQQAYQIVVGLKEGEYPVEEGQWLVATAWNMSCLPLRLHQAKVARKWMKMGLDLARHLEGMKERIASMQTTFENFERVSGDEPDECSQEEAPKASISGSMSQPVLV
Protein: Early light-induced protein 1, chloroplastic (P93735)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Prevents excess accumulation of free chlorophyll by inhibiting the entire chlorophyll biosynthesis pathway (e.g. 5-aminolevulinate synthesis and Mg-protoporphyrin IX chelatase activity), and hence prevent photooxidative stress (By similarity). Probably involved in the integration of pigments into the mature light-harvesting pigment-protein complexes. Light-harvesting chlorophyll (LHC) a/b-binding protein required to ensure a high rate of chlorophyll accumulation during deetiolation in continuous high light. Involved in seed germination. May fulfill a photoprotective functions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:10725357, ECO:0000269|PubMed:16806197, ECO:0000269|PubMed:16829586}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with both photosystems I and II (By similarity). Coisolates equally with monomeric (mLhcb) and trimeric (tLhcb) populations of the major LHC from photosystem II (PSII) in response to 2 hours light stress. {ECO:0000250}.
Interaction partners:
- Photosystem II 22 kDa protein, chloroplastic
- Light-harvesting complex-like protein OHP1, chloroplastic
- Light-harvesting complex-like protein OHP2, chloroplastic
- Stress enhanced protein 2
- Transcription factor HY5
- Chlorophyll a-b binding protein
- Chlorophyll a-b binding protein
- Photosystem I chlorophyll a/b-binding protein 2, chloroplastic
- Transcription factor HY5-like
- Photosystem I iron-sulfur center
Sequence:
MATASFNMQSVFAGGLTTRKINTNKLFSAGSFPNLKRNYPVGVRCMAEGGPTNEDSSPAPSTSAAQPLPKSPSPPPPMKPKVSTKFSDLLAFSGPAPERINGRLAMVGFVAALAVELSKGENVLAQISDGGVSWFLGTTAILTLASLVPLFKGISVESKSKGIMTSDAELWNGRFAMLGLVALAFTEFVKGGTLV
Protein: Marginal zone B- and B1-cell-specific protein (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein) (Q9D8I1)
Organism: Mus musculus (Mouse)
Function: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:19805154}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:21093319}. Secreted {ECO:0000269|PubMed:21688198}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 17
- Immunoglobulin J chain
- POU domain class 2-associating factor 1
- Protein disulfide-isomerase A6
- Endoplasmin
- B-cell antigen receptor complex-associated protein alpha chain
- B-lymphocyte antigen CD20
- Endoplasmic reticulum chaperone BiP
- B-cell antigen receptor complex-associated protein beta chain
- Immunoglobulin lambda-like polypeptide 1
Sequence:
MRLPLPLLLLFGCRAILGSAGDRVSLSASAPTLDDEEKYSAHMPAHLRCDACRAVAFQMGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYGVHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQGQANLEALLCGGTHGPCSQEILAQREEL
Protein: Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF-7 with estradiol protein 6) (DEME-6) (Q5SRH9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGQKGHKDSLYPCGGTPESSLHEALDQCMTALDLFLTNQFSEALSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLLQRAALTFLQGSSHGGAVRPRALHDPSHACSCPPGPGRQHLFLLQDENMVSFIKGGIKVRNSYQTYKELDSLVQSSQYCKGENHPHFEGGVKLGVGAFNLTLSMLPTRILRLLEFVGFSGNKDYGLLQLEEGASGHSFRSVLCVMLLLCYHTFLTFVLGTGNVNIEEAEKLLKPYLNRYPKGAIFLFFAGRIEVIKGNIDAAIRRFEECCEAQQHWKQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATYIYMKAAYLSMFGKEDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGLCLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENSSRSMVSSVSL
Protein: Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (P46580)
Organism: Caenorhabditis elegans
Function: Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell death activator egl-1. Plays a role in heat and oxidative stress resistance.
Subcellular location: Nucleus {ECO:0000269|PubMed:19521535}.
Interaction partners:
- Serine/threonine-protein kinase RIO1
- Protein arginine N-methyltransferase 7
- Protein arginine N-methyltransferase 1
- Methylosome subunit pICln
- pre-mRNA 3' end processing protein pfs-2
- PRotein arginine MethylTransferase
- Small nuclear ribonucleoprotein Sm D3
- Uncharacterized protein.
- S-methyl-5'-thioadenosine phosphorylase
- Methyltransferase domain-containing protein
Sequence:
MSNRTYADNLFPQQVAEQHEEQMSSGSSPKSNSPSRSISSVEAANSRIHIGWMATTLDVAENLDRHVATFCTRLGEFKYNFVVYPIGGVVRAFWTPNGSAENHPPVIDLPDVQLRNDLWESYVVGKISPWIDCDSSDPAFASLSEEHLLKELSYICYLGLQTMAIELTRISSPRTAAILKKWIWTRNSRFTVWVQLPSAIEKCKDYDAFTIEHVDLWTIWADFRKNCGNFSGVYFQVALTISSELPDELTELKLVDRWKAEPLAAFVIESGLFISGRNGEASIPSAHINLLKHLWTTDALRIVLRATTDTFKYNTSIKSEYSQALRHAVRNVNYRSRPDVGEGSNDSTHYLNVIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVVIYLLGGGRGPIGTKILKSEREYNNTFRQGQESLKVKLYIVEKNPNAIVTLKYMNVRTWKRRVTIIESDMRSLPGIAKDRGFEQPDIIVSELLGSFGDNELSPECLDGVTGFLKPTTISIPQKYTSYVKPIMSTHIHQTIKAQSIPYLSRAIPSHGRGEPELDEDEMWIQKYPQGHVRNNMDQIYVVYLSKYIPLAETTKPVFTFEHPNFMNSSNERSDSIEFVMDRNADLMGFAGYFDLQLYKTVMLSIEPSTHTPGMVSWFPAVIPLRDQLRVGEGDRISLKIDRKVDNTGVWYEWHVEKKKTNGESVSTPIQNPNGESYYMRM
Protein: 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) (Q8CHM7)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
Subcellular location: Peroxisome {ECO:0000269|PubMed:10468558}.
Interaction partners:
- Alpha-methylacyl-CoA racemase
- Peroxisomal targeting signal 1 receptor
- 2-Hydroxyacid oxidase 2
- Alanine--glyoxylate aminotransferase
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Branched-chain-amino-acid aminotransferase, cytosolic
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- Citrate synthase, mitochondrial
- Phytanoyl-CoA dioxygenase, peroxisomal
Sequence:
MSESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRLYSKFSARPSSIQHIPFVIEKAVRSSIYGRPGACYIDVPADLVTLQESTTSIKYKECCMPPPLSLAETSAVRAAASVLRSAKQPLLIIGKGAAYSHAEDSIRKLVELCNLPFLPTPMGKGVVPDNHPNCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRPSVTLLGDVNAVSKQLLEQFVKNPWQYPTDSKWWETLREKRKNNEAVSKELASKKSLPMNYYTVFYHVQEQLPRNCFIVSEGANTMDIGRTVLQNYLPRHRLDAGSFGTMGVGLGFAIAAAVVAKERSPGQRVICVEGDSAFGFSGMEVETICRYNLPIIILVVNNNGIYQGFDADTWGKILNFQGTATTIPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQDSLRQALKDTSKPCLINIMIEPQSTRKAQDFHWLTRSNI
Protein: Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) (Q6UXG2)
Organism: Homo sapiens (Human)
Function: May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway. May play a role in apoptosis and cell proliferation through its interaction with HSPA5.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Late endosome membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Lysosome membrane {ECO:0000269|PubMed:21072319}; Single-pass membrane protein {ECO:0000269|PubMed:21072319}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26045166}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}.
Interaction partners:
- E3 ubiquitin-protein ligase HACE1
Sequence:
MAEPGHSHHLSARVRGRTERRIPRLWRLLLWAGTAFQVTQGTGPELHACKESEYHYEYTACDSTGSRWRVAVPHTPGLCTSLPDPIKGTECSFSCNAGEFLDMKDQSCKPCAEGRYSLGTGIRFDEWDELPHGFASLSANMELDDSAAESTGNCTSSKWVPRGDYIASNTDECTATLMYAVNLKQSGTVNFEYYYPDSSIIFEFFVQNDQCQPNADDSRWMKTTEKGWEFHSVELNRGNNVLYWRTTAFSVWTKVPKPVLVRNIAITGVAYTSECFPCKPGTYADKQGSSFCKLCPANSYSNKGETSCHQCDPDKYSEKGSSSCNVRPACTDKDYFYTHTACDANGETQLMYKWAKPKICSEDLEGAVKLPASGVKTHCPPCNPGFFKTNNSTCQPCPYGSYSNGSDCTRCPAGTEPAVGFEYKWWNTLPTNMETTVLSGINFEYKGMTGWEVAGDHIYTAAGASDNDFMILTLVVPGFRPPQSVMADTENKEVARITFVFETLCSVNCELYFMVGVNSRTNTPVETWKGSKGKQSYTYIIEENTTTSFTWAFQRTTFHEASRKYTNDVAKIYSINVTNVMNGVASYCRPCALEASDVGSSCTSCPAGYYIDRDSGTCHSCPTNTILKAHQPYGVQACVPCGPGTKNNKIHSLCYNDCTFSRNTPTRTFNYNFSALANTVTLAGGPSFTSKGLKYFHHFTLSLCGNQGRKMSVCTDNVTDLRIPEGESGFSKSITAYVCQAVIIPPEVTGYKAGVSSQPVSLADRLIGVTTDMTLDGITSPAELFHLESLGIPDVIFFYRSNDVTQSCSSGRSTTIRVRCSPQKTVPGSLLLPGTCSDGTCDGCNFHFLWESAAACPLCSVADYHAIVSSCVAGIQKTTYVWREPKLCSGGISLPEQRVTICKTIDFWLKVGISAGTCTAILLTVLTCYFWKKNQKLEYKYSKLVMNATLKDCDLPAADSCAIMEGEDVEDDLIFTSKKSLFGKIKSFTSKRTPDGFDSVPLKTSSGGLDMDL
Protein: Kinesin family member 11 (Kinesin-like protein KIF11) (F1QK82)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Discs, large
- Centromere-associated protein E
- Kinesin-like protein
- Abnormal spindle-like microcephaly-associated protein
- Centrosomal protein of 55 kDa
- BUB1 mitotic checkpoint serine/threonine kinase
- Dual specificity protein kinase Ttk
- Nucleolar and spindle-associated protein 1
- Kinetochore protein Nuf2
- Kinesin family member 15
Sequence:
MASSQVPAAKKDEKGRNIQVVVRCRPFNTVERKSGSHTVVECDQNRKEVIMRTGGATDKAARKTYTFDMVFGPSAKQIEVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGDRSPNEEFTWEEDPLAGIIPRTLHQIFEKLSNNGTEFSVKVSLLEIYNEELFDLLSPAPDVTERLQLFDDPRNKRGVTIKGLEEITVHNKNEVYQILERGAAKRKTASTLMNAYSSRSHSVFSVTIHMKEITLDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIKALVERGPHVPYRESKLTRILQDSLGGRTKTSIIATVSPASINLEETLSTLDYANRAKSIMNKPEVNQKLTKRTLIKEYTEEIERLKRDLAATRDKHGVYLSVDNYETLNGKIVSQEEQITEYTERIAAMEEELKKIIDLFTDSKQKLEQCTEDLQDKNQRLEEAHKDLSETRHRLNQEEFISTQLQTNESHLYNTADQLLSTAEASTQDVGGLHAKLQRKKDVELHNSKVQESFSQCMENCYNSMQTSLKEQSQKHAAMIDYYRSSVGELLNTNGKVFKETLSAVCESYSSIKGAVGEGVERCKEQVLNQEKLSQDAQNSILEILDEHKQHLEEVLVAQAVPGIRSVMSMNDNLKQTLHKYHNLAEQMQGVKADMMTFFDAYTESLASMRECALQGFNTLRAEHDKLKQQISQAGNSHQVRVAELVQCLQNQMNLLAVDTQNDFEGLSQAASAQIPPLETLQSSIESKCTVAEEQAVSVRARLGSSVHGVISEMNSVTKEGERALEECAGYCGHLQTSLDSLAESGLKWCDEAKGLTESKAQEQLKLIRQTDTAVQDLLKSVEEKGEKAVQDCEARLGQMQQEMEATLGRVEMQTSKDEATLQEHRETLSSINTQALDTVHNFISSELRQDLPTGTTPQRKEYMYPRVLSRPRSREELEEEFRAQQEQLQSELKPCEIVMEVEEEKPVDQDSLEDDVSVSSDGNNTEQSCSDENLICYENGRIPFFKKKSKKENGSKSLNRSKVENDSMSTPPRSKLPLRCQN
Protein: Large ribosomal subunit protein uL4B (60S ribosomal protein L4-B) (Q9P784)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL18A
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein uL3A
- Large ribosomal subunit protein uL3B
- Elongation factor 3
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL22
Sequence:
MAAARPTVSIYNKDGSVSSETLALPFVFKAPIRPDLVRSVHTAVAKNKRQPYAVSEKAGHQTSAESWGTGRALARIPRVGGGGTHRSGQAAFGNMCRSGRMFAPTKTWRKWHVKVNQNEKRYAIASAVAASGVPSLLLARGHRIEEIPEVPLVVDDAVQSFQKTKEAVALLKEIKAYRDVIKVANSRKLRAGKGKLRNRRHVQRRGPLVVFNEDTGIVKAFRNIPGVEIVNVRRLNLLQLAPGGHLGRFVIWTKSAFGLLDSVFGSTTEVAQLKKNYFLPENIISNADVTRLINSDEIQSIVKAAGPSRVKRAHVQKKNPLKNKAVLSRLNPYAKAYKANVKINSEKTPKAAGEKFLSVLHEN
Protein: GTP-Rho binding exocyst subunit (A0A1D8PMI1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Exocyst complex component SEC5
- Exocyst complex component Sec8
- SNARE-binding exocyst subunit
- Exocyst subunit
- Exocyst complex component SEC15
- Exocyst complex protein EXO70
- Exocyst complex component EXO84
- GTP-binding protein RHO1
- Cell division control protein 42 homolog
Sequence:
MFRSPKRSKQKQSQPQPQPPPQPQPQQQPQQQSRSHHHHVPNPAHLFSHPSSHRQQSPYPPPGPGSQTNSGYSTPQRNGMSPLQTNVARMAGPNSPAGSTNSEQQRKLTTDKIISDCYSKVIIDGGRKVNDVSYITHIGVIEYSHYPSAPPPSNTNFGTVKHRILVLCKKNSGRMQLQKGKYQADKNFYQIGRTWDLSELQYIKKVGPEGLILQLNKVYYWKCDEDANRVWKFARYLTQHYGMFMGKYPRLEGFSLDDFMLPTIPKSPTTTVPRSPSLNEPNPDPQLLKSRSLKRKNMPNPVLPQPPTAPATKTPPMPSKPEELYKDMDFTVNGALPQKQMKVISRESNDRGFASKLDPGRSVHEQQKPQGSHSQSGFNSPSQDGTHQAPPPKKHSQHPYFQRSPMNGTDSSSVVSNDSHSFVFGSNDDKNQSRERSDNSSRSSRQQQGSIGTGSQSTNTKGSQTNSYASKKQERESVASQKSAEDVVKEFSEAIPPKRKMAASATVPDFGVEEITDDSEDDQRPAPTFSIRKRQQQIKAQDKKNEETQKVTNEQPIRHHHEDATTSFADKSSHYDEKTFASQKGLGIYPAGSGSFIEESTKLEGQNSASSNLQDLQDLLSSHIDRAQEDSFDFNDVSNEKSADDLNEIPEIRVAGPSNNLNGDTNSFEGEPLEKGLNIVRKSETPENEKVNPSSIIPKDQRDVEVDTLINQIGWSVKDTTDTLMKKLSKELNNSKQDIVSKLVSIDLTNNSGNDIGSALNEVDNMTQIFQKMEVRLKLVRNELQSSATA
Protein: Uroporphyrinogen decarboxylase 1, chloroplastic (UPD1) (URO-D1) (EC 4.1.1.37) (Q93ZB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Coproporphyrinogen-III oxidase 1, chloroplastic
- Coproporphyrinogen-III oxidase 2, chloroplastic
- Protoporphyrinogen oxidase 1, chloroplastic
- Protoporphyrinogen oxidase 2, chloroplastic/mitochondrial
- Porphobilinogen deaminase, chloroplastic
- Uroporphyrinogen-III synthase, chloroplastic
- S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplastic
- Ferrochelatase-2, chloroplastic
- Uroporphyrinogen decarboxylase 2, chloroplastic
- Probable delta-aminolevulinic acid dehydratase 2, chloroplastic
Sequence:
MSLSSPTSACSSSRCYSSGLSFPIGFGSNPINVGLVCYPKRYSIAARKFVVACSSSSSDPLLVKAAKGQAISRPPAWMMRQAGRYMAVYQKLAKKHPSFRERSENTDLIVEISLQPWQAFRPDGVIIFSDILTPLPAFGVPFDIEEVKGPVIQSPIRTEEDMKRLHPIDFEKLQFVGDSLKILRREVGEHAAVLGFVGAPWTIATYIVEGGTTRTYTVIKNMCHTAPDVLRALLSHLTKAITEYVVYQVEHGAHCIQIFDSWGGQLTPEMWERWSKPYIEEIIHAVKKRCPDTPIVFYINGNGGLLERMKGTGADVIGLDWTVDMADGRRRLGSEVSVQGNVDPAYLFSPLPALTEEIERVVKCAGPKGHILNLGHGVLVGTPEEAVAHFFETARNLDYQTLFQNHVPAEKAEPELVV
Protein: Beaten path IIb, isoform A (Q9VEL7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWQTLSTFSTSLRAAAAAVAAQPAATCNCSCKLENAEMHSHMLPSAEIATTAVRRCCCRTKITRSNSSNYSCNYGSNVIQWLLLLCLFCDFGQAALRDVNLLVEPPAVRRGQSVALRCDYQLVEAPLYSIKFYRGQMEFYRYTPGEYPPTKVFQFPGIRVDENGSNATTVLIRNVSFGLSGQFSCEVTADAPLYSTATAFAQMQVVEFPEKRPQLFTEHSRYEPGDVLRANCSTLPSRPRADLRFTINNIPVSIPFTEETQYIRTVDSLIASRLSLKLQLQATHFVAGLSAHGNGNGNGNGNGNGNGNGLANALHLGGGGGGAGGGGLILRCTAQIGDLYQEYKEIELGTPQKDPVPARVTLSSGTGLRGFLETYFATSSGPSNWRGSAGVVAIFLPTALAQLITGS