wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (GNT-I) (GlcNAc-T I) (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (Q60GL7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU368119}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU368119}.
Interaction partners:
- Alpha-mannosidase 2
- Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- alpha-1,2-Mannosidase
- Probable beta-hexosaminidase fdl
- Fucosyltransferase
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Alpha-
- Beta1,4-N-acetylgalactosaminyltransferase A
- Glycoprotein 3-alpha-L-fucosyltransferase A
Sequence:
MRTRKVLLVIGFLVTWTYATYYLLLRQTGIHTSRHQSLQAYKLNSQARDANMQSHHLAKNVFEFVKLKYLEKQPPSVASTPQISIIAAEISAELPEQHVAKSATARIPTKTYLANGEPVFPVVVFACNRVSVKKCIDNLVQYRPSVEQFPIIVSQDCGDEPTKEAILSYGKQVTLIEQPDLSDITVLPKEKKFKGYYKIARHYGWALNTTFAVGFEFVIIVEDDLNVAPDFFEYFLGTHKLLKQDPSLWCVSAWNDNGKAAVVDAAQPELLYRTDFFPGLGWMLTKDLWAELSVKWPKSFWDDWIRHPAQRKDRVCIRPEISRTRTFGKIGVSNGLFFDKYLKHIKLSEDFVQFTKINMSYLLKDNYDNTFLRRVYTYPIVTYDELRRNLIRIEGPVRIQYTTREQYKRTTKMLGLMDDFKSGVPRTAYHGIVSFYYNKRRVHLAPNANWKGYELSWS
Protein: RNA polymerase-associated protein RTF1 homolog (Q92541)
Organism: Homo sapiens (Human)
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}.
Interaction partners:
- RNA polymerase-associated protein LEO1
- RNA polymerase II-associated factor 1 homolog
- Superkiller complex protein 8
- Parafibromin
- Transcription elongation factor SPT5
- RNA polymerase-associated protein CTR9 homolog
- Transcription elongation factor SPT4
- FACT complex subunit SPT16
- DNA-directed RNA polymerase II subunit RPB1
- FACT complex subunit SSRP1
Sequence:
MRGRLCVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFKVHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKKRRGLI
Protein: 40S ribosomal protein S7 (Q6FT00)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- RP41
- Large ribosomal subunit protein uL23
- 40S ribosomal protein S8
- Small ribosomal subunit protein eS21
- L21
- 60S acidic ribosomal protein P0
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS5
- Candida glabrata strain CBS138 chromosome C complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
Sequence:
MSAQAKILSQAPTELELQFAQAFIDLENSSPELKAELRPLQFRSVREIDVAAGKKALAVFVPVPSLTGYHKVQTKLTRELEKKFPDRHVIFLAERRILPKPSRKSRQTQKRPRSRTLSAVHDKILEDLVFPTEIVGKRVRYLVGGNKIQKVLLDSKDIQQIDYKLESFQAVYNKLTGKQIVFEIPETH
Protein: Inactive LRR receptor-like serine/threonine-protein kinase BIR2 (Protein BAK1-INTERACTING RECEPTOR-LIKE KINASE 2) (Q9LSI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pseudokinases lacking protein kinase activity and unable to bind ATP-analogs. Negative regulator of pathogen-associated molecular patterns- (PAMP-) triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24388849}; Single-pass type I membrane protein {ECO:0000269|PubMed:24388849}.
Interaction partners:
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- U-box domain-containing protein 12
- U-box domain-containing protein 13
Sequence:
MKEIGSKPRKLLPLCFIIFLCFCSSVMAADEDDIRCLRGLKASLTDPQNALKSWNFDNTTLGFLCNFVGVSCWNNQENRVINLELRDMGLSGKIPDSLQYCASLQKLDLSSNRLSGNIPTELCNWLPFLVSLDLSNNELNGEIPPDLAKCSFVNSLVLSDNRLSGQIPVQFSALGRLGRFSVANNDLSGRIPVFFSSPSYSSDDFSGNKGLCGRPLSSSCGGLSKKNLGIIIAAGVFGAAASMLLAFGIWWYYHLKWTRRRRSGLTEVGVSGLAQRLRSHKLTQVSLFQKPLVKVKLGDLMAATNNFNSENIIVSTRTGTTYKALLPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKERWSMFQAYQSLKAIAEKQGYSFSEQDDDFPLIFDTQENEKV
Protein: Uncharacterized protein, isoform B (A0A0B4LHC9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
- Sugar phosphate phosphatase
Sequence:
MHSTSYFVAATCAALLLLAATAQSTAAAQSGLQPGGKLIELDEDNWHLMLQGEWMIEFFAPWCPACKNLAPTWERFARVAKDVQVQVAKIDVTTSPSLSGRFFVTALPTIYHVKDGEFRQYRGARDGDALLYFVKKQQWQSIEPLSAWKKPDTTHMSVLSYFFKLSHTLKHTQKLFKDFNGRLQEEYGLPTWGSYALFAIATIFVGAALGLLLVCLVDFVYPPKKSQRQSFSESQDNLTEGLEDLATEEIEDDGDAEENDDEQRDSDEEEQEDDDEEEEDSEEQVGDLATKEKEADSEPEKEEKPEPKQAGDAAPEKTEQVRKRKPRKGD
Protein: Probable transcriptional regulatory protein C8D2.12c (O43075)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized transcriptional regulatory protein C530.05
- Transporter mfs1
- Aspartate--tRNA ligase, mitochondrial
- ATP-binding cassette transporter pdr1
- Tyrosine--tRNA ligase, mitochondrial
Sequence:
MNALNKIPFTRALYHFSRFRSFTTSGWIMSGHNKWSKIKHKKSANDQARSLQIGKLSQGIILAVRQEGANPELNMRLATLLESAKKISMPKSGIENAINRGLGTAGSEGSQVHFIEYEAMHPSGVGLIVEAVTDNRARAASSIKHILRNHGASLSTVKFLFSKKGKVEVNLPPEKRDSMKFEDVLDDAIEAGAEDIVNRPKEYIDEEDEGEFLILTEPSSLNQVAHHFRSKNYEIKDSRLIHIPLEETAIDVPAKDSVREDIQKLIDDLYENEDVMFIHLSILNSHFLPILDE
Protein: BHLHZip transcription factor BIGMAX (Q9GQP6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDNNNALATKEDVFGMEHDQDHTSKHYSRCSSAGSTHTPNSSAHNSDDDDDSGDARHSAAANSTLSYKERRREAHTQAEQKRRDAIKKGYDSLQELVPRCQPNDSSGYKLSKALILQKSIEYIGYLNQQKLKQEDEGSALQKEVTALRIIKNGYENMLQHQQANPGPEEAGLTDEAKFQVFQAIMEEMFETFQHIPMENFKQLTTGIIPWLEEHCKPHILRNILSRTLQQMAQEAMEKQELQAMEQESSEGFS
Protein: Conserved protein (P96874)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Manganese-exporting P-type ATPase
Sequence:
MAIQVFLAKATTTVITGLAGVTAYEILKKAAAKAPLRQTAVSAAALGLRGTRKAEEAAESARLKVADVMAEARERIGEESPTPAISDLHDHDH
Protein: Amorpha-4,11-diene 12-monooxygenase (EC 1.14.14.114) (Amorpha-4,11-diene C-12 oxidase) (Amorphadiene oxidase) (Cytochrome P450 71AV1) (Q1PS23)
Organism: Artemisia annua (Sweet wormwood)
Function: Involved in the biosynthesis of the antimalarial endoperoxide artemisinin. Catalyzes three consecutive oxidations of amorpha-4,11-diene to produce artemisinic acid, with artemisinic alcohol and artemisinic aldehyde as intermediates products, but is unable to oxidize germacrene A. No activity with limonene, alpha-pinene, beta-pinene, pinocarveol, (-)-alloisolongifolene, caryophyllene, (-)-alpha-gurjunene, (+)-gamma-gurjunene, (+)-ledene, (+)-beta-selinene and (+)-valencene as substrates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23638869}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- adenylyl-sulfate reductase
- adenylyl-sulfate reductase
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase
- nitrate reductase
- Nitrate reductase
- Farnesyl pyrophosphate synthase
Sequence:
MKSILKAMALSLTTSIALATILLFVYKFATRSKSTKKSLPEPWRLPIIGHMHHLIGTTPHRGVRDLARKYGSLMHLQLGEVPTIVVSSPKWAKEILTTYDISFANRPETLTGEIVLYHNTDVVLAPYGEYWRQLRKICTLELLSVKKVKSFQSLREEECWNLVQEIKASGSGRPVNLSENVFKLIATILSRAAFGKGIKDQKELTEIVKEILRQTGGFDVADIFPSKKFLHHLSGKRARLTSLRKKIDNLIDNLVAEHTVNTSSKTNETLLDVLLRLKDSAEFPLTSDNIKAIILDMFGAGTDTSSSTIEWAISELIKCPKAMEKVQAELRKALNGKEKIHEEDIQELSYLNMVIKETLRLHPPLPLVLPRECRQPVNLAGYNIPNKTKLIVNVFAINRDPEYWKDAEAFIPERFENSSATVMGAEYEYLPFGAGRRMCPGAALGLANVQLPLANILYHFNWKLPNGVSYDQIDMTESSGATMQRKTELLLVPSF
Protein: Neurabin-1 (H2KYW3)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MTTASELLSDDARARFSHTKALFEQLERQQDVPSFYSPRLQRQPPPPLPPKPPSQCPPSPMSQVERNFSDLAADLDRIQSSPATSRFIQNNFGEENDGISPTTNGVKHTTYAVVKTPKETELETTSENRGLMETRRGLSPERPDVDLTNRKVSFSTAPIPVFSAFSVEDYDRKNEDIDPVASCAEYELERRLERMDLFEVDLEKGAEGLGVSIIGMGVGADSGLEKLGIFVKSITPGGAVHRDGRIRVCDQIVSVDGKSLVGVSQLYAANTLRSTSNRVTFTIGREQNLEESEVAQLIQQSLEHDRMRMMGDEEDDIEEPPPPPSQMPQLPIEQDRPTTSMITKEEIEIRSKIAALELELDVTHKKAEQYHEVLSSTKSHCDQLEKQNEQANYMIKNYQEREKELLNREENHVEQLRDKDVHYASLVRQLKERIDELESKLEEAEERRHSIQNLELIELREKLKEKVEKRNEGMAYRPGGELPHEDKAVMVNLETITPSTKKDAEVSVGSSWTEEYSSPCESPVPRISEPASPALPHKLTHRKLLFPLRKKYAENEFWRATCQPVGLQALHWTVDDVCQLLVSMGLDKYVPEFTINKIDGAKFLELDGNKLKAMGIQNHSDRSLIKKKVKGMKNKIERERKQLERESRTRVIAHTIPM
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Q8HXG5)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9NX14}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NX14}. Note=The interaction with BCAP31 mediates mitochondria localization. {ECO:0000250|UniProtKB:Q9NX14}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 2
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- NADH dehydrogenase 1 subunit C2
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Sequence:
MAARMLGLCGRRLLAVAATRGLPAARVRWESSSSRAVIAPSTLAGKRPSEPTLRWQEDPEPEDENLYEKNPDSHGYDKDPAVDIWNMRVVFFFGFSIVLVLGSTFVAYLPDYRMQEWARREAERLVKYREAHGLPIMESNCFDPSKIQLPEDED
Protein: glycerol kinase (EC 2.7.1.30) (Q8IRJ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAIVNTVNECITGACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAAYKAVENRYQMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNWETSTLPQGEREAFDGA
Protein: Oxidoreductase, putative (Q383X3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Intraflagellar transport protein component, putative
- Intraflagellar transport protein 56 homolog
- C2H2-type domain-containing protein
- Intraflagellar transport protein IFT88, putative
- Uncharacterized protein
- Intraflagellar transport protein 57/55
- IFT80/172/WDR35 TPR domain-containing protein
- Intraflagellar transport protein 80
- Intraflagellar transport protein A1
- Ankyrin repeat protein
Sequence:
MTCKRTFDVIVLGAGAAGCAAGRAIALQNPGANVCIVEQGSSRAPPIVMRVPLFYPFISSVRSTREFLRSYRGVSESCIGGRKLLYVKGCCLGGSSWCNDMRYLRGSNDDYASWKDNDWTMDSVLPIFKALERNLRDGSDVYHGDSGPLLVTDPPPASVSSELNVRWFESCESLGIPQTDEFNNGSPDGFSVFQSHVGKGVRVDVFDCLLEAERHLLPNVTVMSRTRAHRIVFDGKRATGVEVVEGDQSTVLSAPRLVVCLGSIESPALLLRSGVGPQGTVADLQGVGQNLIQSCCATVVFRVTDGSNLRSKSLSWGNSGYLLSQWREYNEDRSGIFASLCEAGAFVRSTPELAHPDLSLTFYPTPNVRWCGWRPFTGFAVRVAHHYPEARGELTLSNDGANCVSTTNGENIRITSRMLSTRHDVQCMDEGLRWVGSLCGPGGDRYNDRSPFASLDVRLHHPADGLATQRSCAAFLARYAESTGDLFGTCALGSVVDSSLRVRGVEGIYVADASVVPAPTCGSSSVIGAAIGFRVASFLQDPVG
Protein: AT03047p (DECAY) (Death executioner caspase related to Apopain/Yama (EC 3.4.22.-)) (Q9VET9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Death-associated inhibitor of apoptosis 1
- Poly [ADP-ribose] polymerase
- Cytochrome c-2
- Cytochrome c-1
- BG1
- Caspase-8
- Death-associated inhibitor of apoptosis 2
- Deterin
- Lamin-C
- Lamin Dm0
Sequence:
MDDTDFSLFGQKNKHKKDKADATKIAHTPTSELDLKRIIISRPTNEDTYENCARAGIALILNHKDVKGQKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAREDHSQNDCFVLAVMSHGTEGKVYAKDMSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTKTFQLRVKPKT
Protein: Putative F-box protein At1g47730 (Q9SXA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box/kelch-repeat protein At2g24250
- F-box protein At5g52880
- F-box/kelch-repeat protein At3g24760
- F-box/LRR-repeat protein At1g67190
- F-box protein At3g08750
- F-box/kelch-repeat protein At2g43270
- Putative F-box/kelch-repeat protein At1g60570
- F-box/kelch-repeat protein At2g22030
- Putative F-box protein At3g22940
- Putative F-box/kelch-repeat protein At4g02310
Sequence:
MEQREEKTENIQRKRSRGKSSSSSLPLDLTSEIFSRLPAKSVVRFRCVSKLWSSITTAPYFTNSFETRPNLMFFFKEGDKFFVFTIPQHNQNPNESYSYSSSEIIDSYHTTYPKRCCVTTLTESVHGLICFRKAATPIIWNPTMRKFKPLRKLDERWKNIKVSLGYDPVDGKHKVVCMPYGNAFYECRVLTLGSDQEWRTVKTNHKNSPFTFHGGVCYRQSRCINGVIYYRADTNSGRVILSFDVRSERFDVIELPWDENFGLVMMMSYKGRLACLGFNHEKNSRSMWVLENVEQREWSCHTYLPISHYEPGLENYFNLTGITNDGELIYVPNTVLERFHVIYFDAIRETFRRVIYKGVADKGFRLRNGLEDKPIRRLHFFPNHIETLMSL
Protein: GTP diphosphokinase CRSH2, chloroplastic (EC 2.7.6.5) (Calcium-activated RelA/Spot homolog 2) (OsCRSH2) (ppGpp synthetase CRSH2) (Q6ATB2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E.coli relA mutants. May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Putative GTP diphosphokinase RSH1, chloroplastic
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase 1
- Nucleoside diphosphate kinase
- Os05g0595500 protein.
- Probable monofunctional riboflavin biosynthesis protein RIBA 3
- Probable bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic
- Inosine triphosphate pyrophosphatase
Sequence:
MASAGGEVVVVDPAAAAVAPDVEHHAPAPRLTPAGSGGRLMAELLGVFNGLTERMGDDVATSSSWTLLFRALKLALPALRDAAGGRSLARALIVAASLADLQMDAEVISAGIVRQAMDAGAVAMADAEAQLGPGAAALLLESLDVKNAPSRVDVADEEAASAVRNRILSGYDVRAVILELAIRLDAMKHLDGVPKHQQRTTSLEVLKVFAPLAHAVGAGALSKELEDLSFWRLYPQAYAQVDQWLSGQEDDCKRVLATCKDDLLQALAADDELRHTVAGFDVKGRYKSRFSAMKKLVKDGRRPEDVHDILGMRVILDHRAGAGDGHRACIRTHEVIKGMWKDVPARTKDYIARPKGDGYRSLHIAVDMSEPGPEGKKRPLMEVQIRTKEMNDAAVFGHALYKGCLADPEEAKRLKDIMLAAAEVAAQHLRDEPATGDQTGVPAAAAAAASAGNIERAFRLLDKNGDGRISMEELTELMEDLGAGGKDAEELMRLLDDNNDGSLSSDEFALFQKRVELKAKLEDKDDEYKEILRQKLQKVDDTGLIHVYRKNLSDKLVSG
Protein: TLR20a protein (W8W3S0)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MRAMFSHPAVLFLWIQCTSGWMHPKCQIYDRGEDLGDFPTWSCNYLPRHAEHYTAACKYVTAIEEDLLGLPPNINTFCISMANGENRSMSLGFFSQFQDLDYLYIKGCFTQILPSGKSHLPNLQHLHLDGMGSGCCDCHIGPHTFRDLVKLSNLTVWGYRLSAMAPDVFHGMTHLQSLIIREPCVDDLSEILCRIMNIKSLIKLNIEAPEIQSLNQSNCSILNTNESMKPVFNNLAISDLLFGEITHIQEGSLAWLQNLTGLSGAFSQEVLLRLPLSGIQQIQYFSCSGSNEIDIESICSVVFLLSIKKIYFHNANLSSLSMSSVELCIGLEYMHLRKPGNFHSTPYLEWHFISGLKNLIQLTINGLKDNRLDICSFQKQPIKWLTKLTLRLNKLQMLFAKQFSCLINLQYLDLADNLISNIEDFAFLGLTNLESLDIGINNITQINTNTFFGLQLTKLTLRLNKLHILFAKQFSCLVKLQYLDLTHNLISNIEDFAFLGLTNLESLDITRNKITQINANTFFGLHSLTWLDLRNNPLIHNIEAMSFTHLTSLRQVFLGQLNNPLTEPVIKLNLTLIFGGILSQLTHLYISSAMRPMQLIIGSNITSKHNLSLQLKGQTVSFEDCDRPFFQSVTHLHADAEEFLCGSEFMGKYFTSVETFDYRSKLSAKSVDLTSINQLIHLRKLTLRQVDLLIQRSADNIFHNLTKLEVLELDNCRIYSLEGSLTKDFKSLKTLYLCIENIYNVFYSFIEPLSSLKYLILPQIQIFCSCDNAWLITWAKGYRQVEVIMFTPYTNPVMSALEDLICLSDNGIDTPNFVKYTEANCTTDVGFVLFAATSLGVMFFMLVVLVHNLAGPYLLPLYHITLGWLSEAMRSNTRGRYHYDAFVSYSGKDERWVVEELLPNLEQSGPPFLRLCLHSRDFQLGKDIVENITDSLYRSRHTLCLVSRHYLRSNWCSLEMKLATSRLQVEQRDILLLVFLEKIPPRRLSAHHRLARLVKTRTYLDWPQDPDQHQAFWDRLWSKLSEA
Protein: RNA polymerase II elongation factor ell1 (Q9P7X2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Activates transcription elongation by RNA polymerase II and pyrophosphorolysis as a complex with eaf1. Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ell1-associated factor 1
- Uncharacterized protein C6G9.15c
- Transcription elongation factor spt4
- Transcription elongation factor spt5
- FACT complex subunit spt16
- FACT complex subunit pob3
- CTD kinase subunit gamma
- Uncharacterized protein C13E7.08c
- RNA polymerase-associated protein C651.09c
- Tetratricopeptide repeat protein 1
Sequence:
MIRNSSISDALPVALGGNEEESPLLMLVQLPKEFLEGYLSGTITDVSLECSDVGTSILANDRSYKCTSVPETAPHEIYRLVDSNSLQLVGRVSQKLQLRRELDSLTAERVKNRTQEAQKEKEEKRIVTLQNDGGSKNTTARKQKQLKKNGLRPLNTSASRIGLSSSPTNTPSPNLPVSQPSASPHYSGDKNSAKGIDLRTRVIQLLAIAPETEDFLRLRTKASLSKLQALLPEVAWKNNMNQWELLNPVYKDVRVFDWRPYSIADRNAVLSRMSNAFDNMQLPPDAPERSLLVSKQKNITKLNNEKRIPPQLAQPTSHVPSFIDTNSPSMPSISSVSSYQQQHRIPKLNASNYSPLLSPSSHRKTSGNLSRTGSESSAVSLSDTTNLNTPISDIPSPGSSTTCSNLSSPHIKRKSRSPPQSLPSTPFPTSSSSTNGTLEPNANSPKKNEQDAWIAKKRRQQRYTTEEMRALAKRFRETYPRYKNLYLKVSSYYDNNDTNNPNLNKLQDELISLHSQLKSWKNTLYDASSELAL
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q57X40)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKNPPQLKSMLFICTFLTSSGVRAKTEPASTKITSRCLEAQYTTHLATDLEGRTTGLNQALTTLKQHLNAWKLLAQAAEAADIRGGAYLLASSAEEEVRRKEQEIQTYTDTIQTAVTRLRRRALYTAALDSIDYKKAAAAPTKGTGAASEFTCAQVFPATAASTKPDCKLDDLTTIFNGDKTLNLEGVHTIKLLTEESLAPPQPKVVSTAKGNQADYNLAPLTPGKCATSASGGADVYVKLDISADPSAKATAEPVQLHKPPGPGPNCIPEPDTKEQIITNNDYVIAAVCRALHASKPAISKPEDYGGDTIATNRANQQLFADYIAETTGEQMTKEQIEAKLKDMYSTKGNNFENNFIKTLNSVTATYTTEDKTKTGKLLEIAKDGNTVKAFAYLDARRTDTKKKADDGREKDGAKKTDTKNKTEEKKDGDNKTTTADCTGTEEGKCDKTKCDWNAEKKQCKVKEGAAVISAVIKAPLLLAVLLP
Protein: Ribosomal protein S6 kinase (EC 2.7.11.1) (Q7ZVH8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPLAQCADPWQKLPMGHLENEDDSMIEDDSLVHDEGSVKEISITHHVKEGSEKADPRQFELRKVLGQGSFGKVFLVKKISGPDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDDDGHIELTDFGLSKESIDHENKAYSFCGTVEYMAPEVVNRRGHTQSADWWSYGVLMFEMLTGALPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRNLFKRNPGNRLGAGPDGVEGIKRHSFFTRIDWNKLFRKEVPPPFKPAIKKPDDTFYFDSEFTAKTPRDSPGVPPSANAHQLFRGFSFVATGVEEESQSPIQSNINMSSILQSHRSTLQFTDAYEVKEDIGVGSYSVCKRCVQKSTGMDYAVKIIKKERRDPTEEVEILLRYGQHPNIITLKDVFDDGRSVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLTGGYWNSVSHDAKDLVSKMLHVDPHKRLTAAQVLRHPWIINKDQLPKYQLNRQDAPHLVKGAMAATYSALNRNVSPVLDPVGCSTLAQRRGLKKLTSTAL
Protein: Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) (Q96PE1)
Organism: Homo sapiens (Human)
Function: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:21421844, ECO:0000269|PubMed:22013897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, filopodium {ECO:0000269|PubMed:21421844}. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact. {ECO:0000269|PubMed:21421844}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Catenin beta-1
- Low-density lipoprotein receptor-related protein 6
- Frizzled-4
- Disks large homolog 1
- Norrin
- Glycogen synthase kinase-3 beta
- Proto-oncogene Wnt-3
- Protein Wnt-7a
- Leucine-rich repeat serine/threonine-protein kinase 2
Sequence:
MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV