wanglab/gogpt-training-data huggingface dataset:
Protein: Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) (P11875)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Isoleucine--tRNA ligase
- Leucine--tRNA ligase
- Lysine--tRNA ligase
- Methionine--tRNA ligase
- Lysine--tRNA ligase, heat inducible
- Glutamine--tRNA ligase
- Proline--tRNA ligase
- Glutamate--tRNA ligase
- Serine--tRNA ligase
- Asparagine--tRNA ligase
Sequence:
MNIQALLSEKVRQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLNGIASKVEIAGPGFINIFLDPAFLAEHVQQALASDRLGVATPEKQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHKVIRANHVGDWGTQFGMLIAWLEKQQQENAGEMELADLEGFYRDAKKHYDEDEEFAERARNYVVKLQSGDEYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGEPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWAIVRKAGYVPESVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKAEIDEEQLAAAPVIIREDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDLAGLFSGFYEHCPILSAENEEVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
Protein: Uncharacterized protein (Q384D6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDEDMCVAAAAFRGTEEYAAVFDLEVWKAQQQARLRSEINEEKARLQKAVAEEVRKKEAQRISELDALQQELQQLARRLQVREEALHRRISQFEVREAAFEDRRVKVAEQHEQHLLSLETRTRRQREEAATQVDVLKAQLAERDRSVALLEERLSAAESEYDKLQRYVSRVSTSDEDTTRTDALEEQLCAANSAMAKLQLRLKERDSELALASRERDQLKRTCEVYKDQLYQLTKRYNHLQEQCCRRERMRLDEERRRIDDSKRRYGIVEPRMGMETRSPRCYDLLGTLVAGGTSTRRPGDALAHDDCTLLLHELKSDVEKGMQKFGRRGKGVTQTKRRQDLVFAEVVVRQDEEEPLHVEGGSDRVCPVAHGGPAVPDTELDTGYADDFANTTISSLSHREGENHGVAVSTFPGMPIEEGLGQTDVGDISSTYCYADIESWGSGDEETRCRPIERKLRGDAAADLPPLAPAPAISDSFTDRSAAQHVSPPREPMEGPGATSMVSTRDSTRGEMIAFVEKLQENRRKLLDSGVYREDDSIVKEMSDKIALYENFLSQNF
Protein: ORF3a protein (Accessory protein 3a) (Protein 3a) (Protein U274) (Protein X1) (P59632)
Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV)
Function: Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Down-regulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.
Subcellular location: Virion. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein. Secreted. Host cytoplasm. Note=The cell surface expressed protein can undergo endocytosis. The protein is secreted in association with membranous structures.
Interaction partners:
Sequence:
MDLFMRFFTLGSITAQPVKIDNASPASTVHATATIPLQASLPFGWLVIGVAFLAVFQSATKIIALNKRWQLALYKGFQFICNLLLLFVTIYSHLLLVAAGMEAQFLYLYALIYFLQCINACRIIMRCWLCWKCKSKNPLLYDANYFVCWHTHNYDYCIPYNSVTDTIVVTEGDGISTPKLKEDYQIGGYSEDRHSGVKDYVVVHGYFTEVYYQLESTQITTDTGIENATFFIFNKLVKDPPNVQIHTIDGSSGVANPAMDPIYDEPTTTTSVPL
Protein: Uncharacterized protein (Q3UYL3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
KMRNLQRCVSELEEEKQQLVKKKTKVESEIRKEYMEKIQGAQKGPANKSHAKELQELLREKQQEVKQLQKDCIRYLERISALEKTVKALEFVHTESQKDLDVTKGNLAQAVEHRKKAQAELSSFKILLDDTQSEAARVLADNLKLKKELQSNKESIKSQIKQKDEDLLRRLEQAEEKHRKEKKNMQEKLDALHREKAHVEETLAEIQVSLTRKDQEMKELQGSLDSTLAQLAAFTKSMSSLQDDRDRVIDEAKKWERRFGDAIQTKEEEVRLKEENCIALKDQLRQMAIHMEELKITVSRLEHDKEIWESKAQTELQHHQKAYDKLQEENKELTSQLEDARQLYHDSKNELTKLESELKSLKDQTTDLNNSLEKCKEHENNLEGIIKQQEADIQNCKFSCEQLETDLAASRELTSRLHDEINAKEQKIISLLSGKEEAIQLAVEELHQQHSKEIKELENLLSQEEEENVALEEENKRALEKTNQLTEALEAIKKESFEQKAQLDSFVKSMSSLQDDRDRIVSDYRQLEERHLSAILEKDQLIQDAAAENNKLKEEMRGLRSHMDDLNSENAKLDAELVQYRRDLNEVIAIKDSQQKQLLDTQLQQNKELRNECTKLEERLKGLEAEKQSLQMSSDALQKEKQGLSKEIKNLQTQLTALQEEGTLGVYHAQL
Protein: FMRFamide-like neuropeptide 18 [Cleaved into: EMPGVLRF-amide; SVPGVLRF-amide 1; SVPGVLRF-amide 2; EIPGVLRF-amide; SEVPGVLRF-amide; DVPGVLRF-amide; SVPGVLRF-amide 3] (Q9N4V0)
Organism: Caenorhabditis elegans
Function: FMRFamide-like neuropeptides. Ligand to G-protein coupled receptor npr-1. Involved in modulating locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages, acting via npr-1. Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Neuropeptide receptor npr-1
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- FMRFamide-like neuropeptides 14
- FMRFamide-like neuropeptide 21
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 7
- FMRFamide-like neuropeptides 13
- FMRFamide-like neuropeptides 6
Sequence:
MQRWSGVLLISLCCLLRGALAYTEPIYEIVEEDIPAEDIEVTRTNEKQDGRVFSKRDFDGAMPGVLRFGKRGGVWEKRESSVQKKEMPGVLRFGKRAYFDEKKSVPGVLRFGKRSYFDEKKSVPGVLRFGKRDVPMDKREIPGVLRFGKRDYMADSFDKRSEVPGVLRFGKRDVPGVLRFGKRSDLEEHYAGVLLKKSVPGVLRFGRK
Protein: Caldesmon 1 (F6QLP8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XRAEQARIQEEQRRVAEAQKKAKAEEEEKARIEEQRQKQQLEEQRSEKREAKDKGEKGAEKADRKGVNEREAPDDRLQTAVPKTQIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSPSRSGGRASGDKEAEGAPQVEAGKRLEELRRRRGETENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEERA
Protein: Uncharacterized protein (Q5A4L1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Mitochondrial fission process protein 1
- Bud21p
- Beta-lactamase-related domain-containing protein
- Major facilitator superfamily
- Uncharacterized protein
- Png2p
Sequence:
MSQQEKSTFRSYTKEELHDLLTKLELPVKSKTTKKAMVEILDDFVEKHPEELDNIEKILQTEEDEDDDDDEEDEDIVEVVKIDGEEDEDEDDEEEEEEEAEDDEEEEEDDKDYEAPPPLNLKEWVVDPIIAQSETFIEKFYEFTDNVGITYLNQSEKLRDQLSSTVTLNYLQIGVELLIFIYTFIRVVPLNENNLIHQIFHDNIPYLSIITWPSLEISSIFQYKSIITFIIWSITSIIIPSIVSYFINFTSRVIEIEDDEYLFRVYSFDPFIFALSKILTFYFIGQFALIEFATCECFISAIFNKTLLNIGLYQSFATNNLGTLPYVLGGVNVLIALYAQFEEY
Protein: Ribosome biogenesis inhibitor MINAS-60 (MINAS-60) (P0DW27)
Organism: Mus musculus (Mouse)
Function: Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P0DW28}.
Interaction partners:
Sequence:
MKDEVVVVTGLAAMEPLIVHRMIVERTAAGTMIIETWTTAHTHESMAVRRASMSMTTHLKSKVQRIPTRPPRAPRLSVGGGGGTGTVPLARQASPETATIGTRTIGPSKGRRRRRRMRRRRRRRPVTSSC
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7) (O06491)
Organism: Bacillus subtilis (strain 168)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Interaction partners:
- Glutamyl-tRNA
- Aspartyl/glutamyl-tRNA
- Asparagine--tRNA ligase
- Glutamate--tRNA ligase
- 5-oxoprolinase subunit C
- Biotin carboxylase 2
- Biotin carboxylase 1
- 1-phosphofructokinase
- Aspartate--tRNA
- Polyketide synthase PksJ
Sequence:
MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFLALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPIYDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAAAVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITRTVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEARESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTDNADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDVFEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLPLGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL
Protein: Inclusion membrane protein A (P0CI27)
Organism: Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Function: Chlamydia replicate within an intracellular vacuole, termed an inclusion. IncA is probably involved in the homotypic fusion of inclusions.
Subcellular location: Secreted {ECO:0000250|UniProtKB:A0A0H3MD02}. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane {ECO:0000269|PubMed:9826388, ECO:0000305|PubMed:10603409, ECO:0000305|PubMed:11402010}; Multi-pass membrane protein {ECO:0000255}. Note=Secreted, probably by a type III secretion system (Probable) (PubMed:9826388). Localized in the inclusion membrane (Probable) (PubMed:9826388). In the inclusion, the C-terminus faces the host cytosol (By similarity). {ECO:0000250|UniProtKB:A0A0H3MD02, ECO:0000269|PubMed:9826388, ECO:0000305|PubMed:10603409, ECO:0000305|PubMed:11402010}.
Interaction partners:
Sequence:
MTTPTLIVTPPSPPAPSYSANRVPQPSLMDKIKKIAAIASLILIGTIGFLALLGHLVGFLIAPQITIVLLALFIISLAGNALYLQKTANLHLYQDLQREVGSLKEINFMLSVLQKEFLHLSKEFATTSKDLSAVSQDFYSCLQGFRDNYKGFESLLDEYKNSTEEMRKLFSQEIIADLKGSVASLREEIRFLTPLAEEVRRLAHNQQSLTVVIEELKTIRDSLRDEIGQLSQLSKTLTSQIALQRKESSDLCSQIRETLSSPRKSASPSTKSS
Protein: Autophagy-related protein 13 N-terminal domain-containing protein (Q55BY0)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Probable autophagy-related protein 17
- Autophagy-related protein 101
- Serine/threonine-protein kinase atg1
- Probable serine/threonine-protein kinase DDB_G0291918
- Ubiquitin-like domain-containing protein
- Autophagy-related protein 9
- Phosphatidylinositol 3-kinase VPS34-like
- Probable serine/threonine-protein kinase vps15
Sequence:
MDSRYSDLIRKTISKISQCILLSRVETSSVSRRVNKTFHLETEESDIHRQEIDRIVLKNDMRILFVIEIHFDENVGLGLNTIVESWRIIFDPREIDNSVELPKFYKNVIILIRTIYAMLRNIPCYSLFKNFSKNRSATCSVNYQLRVCDSQSITTPSFPLSTSIKTVSFTAIPTPMGILKIDLSYKENLTREISASSHIGLESQFIIKDYNNYQSGNNYDNNNNNSNNSNSNNDYTNIINNTNNININNNNNNNNDNNNNNTNDNNLSTSYNRDYPSSYPQLTRMGTLQDLLNNNNNNNNSKPTSSSPYDSNSMPFETNNNFNNYNNSNSNANYNFNNINSNNNNNNNNNNFNNFNTNNNSYNNNNNIINSNNNNYNFNENNNNNPQSNPIFIPGMQNNRQYQQQQQQQQQQYSSSFNKPPSLSSSPPFSSNSIKIGSGNANYNNQYGSSPPFGSTTTTTTTSNNINTSGGININNHPSSNPLPIRQVSFTIPNQTTGISPTSYNNQQSKTRATSAPIAIHQQAPPFQNFPKSSSSGTKSPPFHVSISPFKEPSTLDYYSGGGSTGTSGGLIGSTGASGGGLVGNNSNNNLTLLNNSNGIGGSGGGLVGNNSSGNLTLLNSNNNSNNNLIGISGNNALFNNPLYQSSSPGSTNSFGASGIDRLNNSSMKNSKISQIHGPLLLSEHHINQFTKDGSRISSPPINTLDDNDDAVFVSTLRNSKQTTHESEIADFLKLCKIAPPLKLFNNDNLSLNTTNSQHSLQIGNEIMLLSNINFNKPTSQQYQQPPQQQQQQYYQNF
Protein: Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LSH-R) (P30730)
Organism: Mus musculus (Mouse)
Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P22888}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P22888}.
Interaction partners:
- Follitropin subunit beta
- Glycoprotein hormones alpha chain
- Lutropin subunit beta
- Pro-opiomelanocortin
- Pro-glucagon
- Gastric inhibitory polypeptide
- Natriuretic peptides A
- VIP peptides
- Pituitary adenylate cyclase-activating polypeptide
- Steroid 17-alpha-hydroxylase/17,20 lyase
Sequence:
MGRRVPALRQLLVLAMLVLKQSQLHSPELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSEILIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVSKISSSEFNFILEICDNLYITTIPGNAFQGMNNESITLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGTFQGATGPSILDVSSTKLQALPSHGLESIQTLIATSSYSLKTLPSREKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVREANNETLYSAIFEENELSGWDYDYDFCSPKTLQCTPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWIFSTLMATLPLVGVSSYMKVSICLPMDVESTLSQVYILSILLLNAVAFVVICACYVRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPVNSCANPFLYAVFTKAFQRDFFLLLSRFGCCKHRAELYRRKEFSACTFNSKNGFPRSSKPSQAALKLSIVHCQQPTPPRVLIQ
Protein: Pre-mRNA-splicing factor 18 (O94406)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Participates in the second step of pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor slu7
- Pre-mRNA-splicing factor brr2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Sequence:
MDFLKEEIERKRRQLEGTSELPVKKAFRRGDWEKEREKKYLQEKQQKDEQRELKKRKLEEERLKYEEKKLRISRLANKESSRNEELLTETTTPSPAVKASPASTKLSVSENDRLSIPEITKDNLTLTEIIAKLREMKEPIRLFGESEEATIQRYYSLLKYKKLEEIENELLTKGVETIDFEHATTTKPKVSKQVVAFLQHGIRIWDNFLSSKSINSFESSESQMQLKIFRQAKQDLDVLIQLIVDEALNDDIFKSIAEICYRCQKHEFVKANDMYLRLTIGNAPWPIGVTMVGIHERSAHQRLQANPSSNILKDEKKRKCLQALKRFITFQERESSNLPEYTD
Protein: Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Q8C6N3)
Organism: Mus musculus (Mouse)
Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.
Subcellular location: Membrane; Single-pass type III membrane protein.
Interaction partners:
Sequence:
MAEQLAFLIGGIIGGLLLLIGVSCCLWRRFCATFTYEELPETSDPATISYFSRKEDRLYQYSGTPPGRLPSVPFVVPPSHQGRDWVPLHGGDWAVAPQDPCPVPEHMACTSSAKPGDACEMGSINPELYKSPEDTSETGFPDGCLGRLWFSVEYQQESERLLVGLIKAQQLQVPSETCSTLVKLHLLPDERRFLQSKTKHKICNPQFDENFIFQVSSKSVTQRVLKFSVYHVNKKRKHQLLGQVLFPLKNETLAGDHHRIIWRDLEAKNLEPPSEFGDIQFCLSYNDYLSRLTVVVLRAKGLQLQEDRSVVSVFVKVSLMNHNKFVKCKRTSAVLGSVNPVYNETFSFKVDTNELDTASLSLVVLQTTEGNKSSPLGRVVVGPYMYTRGKELEHWGEMLRKPKELVKRWHALCRPTEP
Protein: Polyubiquitin 10 [Cleaved into: Ubiquitin] (Q8H159)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Actin-2
- E3 ubiquitin-protein ligase UPL4
- Protein NBR1 homolog
- Small ribosomal subunit protein uS7y
- E3 ubiquitin-protein ligase PRT1
- E3 ubiquitin-protein ligase UPL3
- Actin-7
- Small ribosomal subunit protein uS7z
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
Sequence:
MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGF
Protein: Actin B (EC 3.6.4.-) (P12433)
Organism: Trypanosoma brucei brucei
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
Sequence:
MSDEEQTAIVCDNGSGMVKSGFSGDDAPRHLFPSIVGPPKNEQAMMGSAKQEMFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMETGMTFTTSAQKEIVRNIKEQLCYVALDFDEEMTNSAKSVSEEPFELPDGNVMQVGNQRFRCPQALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF
Protein: Solute carrier family 40 member 1 (Ferroportin-1) (Q9I9R3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May be involved in iron export and also in transfer of iron between maternal and fetal circulation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9NP59}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP59}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NP59}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP59}.
Interaction partners:
- Ceruloplasmin
- Solute carrier family 40 protein
- Solute carrier family 11 member 2.
- Transferrin receptor protein 1
- Transferrin receptor 2.
- Transferrin receptor 1b.
- Hemochromatosis type 2
- Ferritin
- Mitoferrin-1
- STEAP family member 3, metalloreductase.
Sequence:
MDSPASKKPRCERFREFFKSAKFLIYVGHALSTWGDRMWNFAVAVFLVELYGNSLLLTAVYGLVVAGSVLLLGAIIGDWVDKNPRLKVAQTSLVVQNSAVILCGALLMAVFQFKQQLSSMYDGWLLTTCYIMVISIANIANLASTAMSITIQRDWVVVVAGDDRSKLADMNATVRIIDQLTNILAPMLVGQIMAFGSHFIGCGFISGWNLFSMCLEYFLLWKVYQKTPALAFKAGQKDSDDQELKHLNIQKEIGNTESPVEASQLMTESSETKKDTGCCYQMAEPIRTFKDGWVAYYNQSIFFAGMSLAFLYMTVLGFDCITTGYAYTQGLNGSVLSLLMGASAVSGICGTVAFTWIRKKCGLIRTGFIAGVTQLSCLTLCVASVFAPGSPFDLSVSPFEEVLRHLFGDSGSLRESPTFIPTTEPPIQANVTVFEEAPPVESYMSVGLLFAGVIAARVGLWSFDLTVTQLIQENVIESERGVINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVIISVSFVAMGHMMYFRFAYKSLGSRLFLFCSPEQKPDPNIPSLPNSV
Protein: Insulin-like growth factor-binding protein 3 (I6XXP7)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLRARPALWAAALTALTLLRGPPAARAGAGTMGAGPVVRCEPCDARAVAQCAPPPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVGRLRPYLLPSASGNGSESEEDHSMGSTENQAGPSTHRVPVSKFHPIHTKMDVIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNMLSPRGIHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGFDVKGKGDVHCYSMESK
Protein: Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (F1QG80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL38
- Ribosomal protein L4
- Large ribosomal subunit protein eL21
- 40S ribosomal protein S6
Sequence:
MRFFSSSFLPKLSAMAPIKKQVTKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVSIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANTKESYELRYFQINQDEEEEDED
Protein: Fluoroquinolones export ATP-binding protein Rv2688c (EC 7.6.2.-) (P9WQL7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for energy coupling to the transport system.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Fluoroquinolones export permease protein Rv2686c
- Fluoroquinolones export permease protein Rv2687c
Sequence:
MTALNRAVASARVGTEVIRVRGLTFRYPKAAEPAVRGMEFTVGRGEIFGLLGPSGAGKSTTQKLLIGLLRDHGGQATVWDKEPAEWGPDYYERIGVSFELPNHYQKLTGYENLRFFASLYAGATADPMQLLAAVGLADDAHTLVGKYSKGMQMRLPFARSLINDPELLFLDEPTSGLDPVNARKIKDIIVDLKARGRTIFLTTHDMATADELCDRVAFVVDGRIVALDSPTELKIARSRRRVRVEYRGDGGGLETAEFGMDGLADDPAFHSVLRNHHVETIHSREASLDDVFVEVTGRQLT
Protein: Calcium load-activated calcium channel (CLAC channel) (GEL complex subunit TMCO1) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3) (Q9UM00)
Organism: Homo sapiens (Human)
Function: Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:27212239, ECO:0000269|PubMed:36261522}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:27212239}. Golgi apparatus membrane {ECO:0000269|PubMed:10393320}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320}. Mitochondrion membrane {ECO:0000250|UniProtKB:C5HGF3}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320}. Note=The first transmembrane region is required for localization to the endoplasmic reticulum (PubMed:27212239). A publication reported localization in cytoplasm and nucleus (PubMed:22714896). Nuclear localization is however in contradiction with two other reports (PubMed:10393320, PubMed:27212239). {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:22714896, ECO:0000269|PubMed:27212239}.
Interaction partners:
- PAT complex subunit CCDC47
- Protein transport protein Sec61 subunit alpha isoform 1
- BOS complex subunit NCLN
- BOS complex subunit TMEM147
- Large ribosomal subunit protein uL22
- Phenylalanine--tRNA ligase beta subunit
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit gamma
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL13
Sequence:
MPRKRKCDLRAVRVGLLLGGGGVYGSRFRFTFPGCRALSPWRVRVQRRRCEMSTMFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAGGFLGPPPPSGKFS
Protein: Asator, isoform I (EC 2.7.11.1) (L0MPX5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHLQEYLRNDENASAPDDGNQSCQPSSKQDQYLSPNRNCQKNLLRLYPPPPSKPPPLVGAILQTRLLHQISPSAIADADADLNAVGELLYPNVLQRSATLPAKHNRLGVRSRVTFKVPSSNLPAQDSYSHQPRNQVAVAAKDGILVDVKAKESVKMTSEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSDYMHGNITQMTVAASNASGTEYIRKRAEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPSMIEREDVQYTKLEEGAPTKFITMKPNGECDNVDIAAKCIFEQKHVEANDDIVGRASLSGVEQHYKSQIKKHNSPEIANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAAPIGINSSSTKFGSQHGQIFGLAAMPPINRRSATSTNLRPSSSASQRINSGSTIGGAVGNGSNTARSSVAGDHSVTQFALIDDENVSALQQVTKGGALTLASQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLDISLPLNEAKPFPQHGVAGTGKLINPPGEAKGRPKRYTLNITGIENYEALRISIPNCWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPSTSSVLRNRLPSPFKKDSALQLNSTNDSLDKSRHRNSLPNVSVNDIFDDLQMKLNLDLGSAIQENNCCISGRLEIRVIPKDTSHPDDSVYYDAMGAVKNTPTANEGHDHSDQAVNNCDEMEATSAVIAFPNKSISKIMSPPGRDATEERTGASLCSLYSAGVNKLKLNGNTAPRTQFKKGSTDGFGENESEFDFPLLNPSKIPVRQSKCASWAGADFISASKPLESAEVPQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPPNISDLTPGLRRRRESTEGKYVTDPTQLPLKFQRPRSRTSSRTRGIPNAMLENSDDNGTVMSAEKTGHGHVVKTEGVKNFTTSENSSEVNPKCTISPPPGDPKIENSARLRRYRHNID