wanglab/gogpt-training-data huggingface dataset:
Protein: Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) (B2R6P4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00037875}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037875}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00037803}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037803}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004163}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037801}. Late endosome membrane {ECO:0000256|ARBA:ARBA00037845}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037845}. Lysosome membrane {ECO:0000256|ARBA:ARBA00037863}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037863}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDFSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK
Protein: Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) (O75387)
Organism: Homo sapiens (Human)
Function: Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine. The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19443642}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Note=Located in the apical plasma membrane of the podocyte foot processes (PubMed:19443642). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q8BSM7, ECO:0000269|PubMed:19443642}.
Interaction partners:
- Large neutral amino acids transporter small subunit 2
- Amino acid transporter heavy chain SLC3A2
- Large neutral amino acids transporter small subunit 1
Sequence:
MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA
Protein: High-affinity glucose transporter ght2 (Hexose transporter 2) (O74969)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: High-affinity glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- SNF1-like protein kinase ssp2
Sequence:
MGFKRGKNFTLVMLIFVSMAGWMFGADTGSIGGVTSMRDFRERYADRYDPITDQYSLSSARQGLLTGMVNVGSLFGCIISSPIADRFGKRLSIIGFCAVYIIGIIVQVTAVPSWVQIMVAKIWTGIGIGALSVLAPGYQSETAPPSIRGTVVVTYQLFVTGGIFIAACINMGTHKLHKTAQWRVSIGINLLWGIITMIGILFLPESPRYLIQVGKDEEAVRVLSESAELFPDSEEVQNEYHRLKSSIDEEFAGGPCSWASIFGKDIRYRTFLGMFVMSLQQLTGNNYFFYYGFSVMQGAGINSPYLSAMILDAVNFGCTFGGMYVLERFGRRNPLIIGGIWQSICFFIYSAVGSRALYHKNGTSNTRAGAVMIVMACLFIFGFAQTWAPAAYVIVGESYPVRYRSKCAAVATASNWLWNFLISFFTPFIQASIGFKYGYVFASCNLTGAIVIFLFAKETKGLTLEEINELYMSVIKPWESGNFKLNYSEQKKVEKEKSRKGGARGESVEYVERASNTDSSPQYSSHEEDYA
Protein: Arabinanase/levansucrase/invertase (Emb|CAB66926.1) (Q9FJW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKKNNKYNKKSTSLHCNDAGGCRYSLLTIVWTVVGFFLVAHLISLYSRKDNNIHQQVSSDQLQVVHHLAHPIVRELIRVEEEVLRMPPPRKRSPRTSKRRSRKPIPLVEEFLDDKSPIRHLFFPGIKTAAFGPTKDMGNETSYYFPGKIWMDTQGNPIQAHGGGILLDVKSNTYYWYGEYKDGPTYHAHKKGPARVDIIGVGCYSSKDLWTWKNEGIVLGAEETNKTHDLHKSNVLERPKVIYNEKTEKYVMWMHIDDANYTKASVGVAISNSPTGPFEYLYSKRPHGFDSRDMTVFKDDDGVAYLIYSSEVNSVLHIGPLTEDYLDVTPVMKRVMVGQHREAPAIFKHQNIYYMVTSWCTGWAPNEALAHAAESIMGPWEKLGNPCIGGNKVFRLTTFFAQSTYVIPLPGVPGAFIFMADRWNPADLRDSRYVWLPLVIGGPADQPLEFNFGFPSWSRVSIYWHSKWRLP
Protein: Guanosine nucleotide diphosphate dissociation inhibitor 2 (AtGDI2) (O24653)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.
Interaction partners:
- Ras-related protein RABF1
- Ras-related protein RABF2a
- Ras-related protein RABF2b
- Ras-related protein RABH1e
- Ras-related protein RABH1b
- Immunoglobulin E-set superfamily protein
- Rho GDP-dissociation inhibitor 1
- Ras-related protein RABH1d
- Ras-related protein RABH1c
- At1g12070
Sequence:
MDEEYEVIVLGTGLKECILSGLLSVDGVKVLHMDRNDYYGGESTSLNLNQLWKKFRGEEKAPEHLGASRDYNVDMMPKFMMGNGKLVRTLIHTDVTKYLSFKAVDGSYVFVKGKVQKVPATPMEALKSSLMGIFEKRRAGKFFSFVQEYDEKDPKTHDGMDLTRVTTKELIAKYGLDGNTIDFIGHAVALHTNDQHLDQPAFDTVMRMKLYAESLARFQGTSPYIYPLYGLGELPQAFARLSAVYGGTYMLNKPECKVEFDEGGKVIGVTSEGETAKCKKIVCDPSYLPNKVRKIGRVARAIAIMSHPIPNTNDSHSVQVIIPQKQLARKSDMYVFCCSYSHNVAPKGKFIAFVSTDAETDNPQTELKPGTDLLGPVDEIFFDMYDRYEPVNEPELDNCFISTSYDATTHFETTVADVLNMYTLITGKQLDLSVDLSAASAAEE
Protein: COP9 signalosome complex subunit 5 (OsCSN5) (JUN-activation-domain-binding protein 1) (Signalosome subunit 6) (Q8H936)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and response to hormones (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF (By similarity). Involved in early response to iron deficiency (Probable).
Interaction partners:
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 1, putative, expressed
- Os01g0279200 protein.
- Os07g0490800 protein
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 6
- Os10g0506700 protein
- Os10g0506300 protein
- Mov34/MPN/PAD-1 family protein, expressed
Sequence:
MEPTSSAAMARQTWELENNIPAAASDPDALDAIYRYDEAAQARVQQEKPWANDPHPFRRAKISALALLKMVVHARAGGTIEVMGLMQGKCEGDAIVVMDAFALPVEGTETRVNAQADAYEYMVEYSTINKQAGRLENVVGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFLAVVIDPTRTVSAGKVEIGAFRTYPKDYKPPDEPVSEYQTIPLNKIEDFGVHCKQYYALDITYFKSSLDSHLLDLLWNKYWVNTLSSSPLLGNRDYVAGQIFDLADKLEQAEGQLAHSRYGMLMPSQRKKEQEESPLAKVTRDSSKITAEQVHGLMSQVIKDILFNSVHPSNKASTSAPDSSGPEPMVEA
Protein: E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) (O88846)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P78317}. Nucleus {ECO:0000269|PubMed:11319220, ECO:0000269|PubMed:9710597}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20943951}. Nucleus, PML body {ECO:0000269|PubMed:20943951}.
Interaction partners:
- Small ubiquitin-related modifier 3
- Ubiquitin-conjugating enzyme E2 D1
- Ubiquitin-conjugating enzyme E2 N
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier
- Small ubiquitin-related modifier
- Mediator of DNA damage checkpoint protein 1
- KxDL motif-containing protein 1
- Protein PML
- Polyubiquitin-C
Sequence:
MSTRNPQRKRRGGAVNSRQTQKRTRETTSTPEISLEAEPIELVETVGDEIVDLTCESLEPVVVDLTHNDSVVIVEERRRPRRNGRRLRQDHADSCVVSSDDEELSKDKDVYVTTHTPRSTKDEGTTGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI
Protein: Scarecrow-like protein 9 (AtSCL9) (GRAS family protein 13) (AtGRAS-13) (O80933)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein PAT1 homolog
- Scarecrow-like protein 6
- Scarecrow-like protein 15
- Scarecrow-like protein 27
- Thiohydroximate-O-sulfate sulfur/sulfate-lyase
Sequence:
MITEPSLTGISGMVNRNRLSGLPDQPSSHSFTPVTLYDGFNYNLSSDHINTVVAAPENSVFIREEEEEEDPADDFDFSDAVLGYISQMLNEEDMDDKVCMLQESLDLEAAERSLYEAIGKKYPPSPERNLAFAERNSENLDRVVPGNYTGGDCIGFGNGGIKPLSSGFTLDFRNPQSCSSILSVPQSNGLITIYGDGIDESSKNNRENHQSVWLFRREIEEANRFNPEENELIVNFREENCVSKARKNSSRDEICVEEERSSKLPAVFGEDILRSDVVDKILVHVPGGESMKEFNALRDVLKKGVEKKKASDAQGGKRRARGRGRGRGRGGGGGQNGKKEVVDLRSLLIHCAQAVAADDRRCAGQLLKQIRLHSTPFGDGNQRLAHCFANGLEARLAGTGSQIYKGIVSKPRSAAAVLKAHQLFLACCPFRKLSYFITNKTIRDLVGNSQRVHVIDFGILYGFQWPTLIHRFSMYGSPKVRITGIEFPQPGFRPAQRVEETGQRLAAYAKLFGVPFEYKAIAKKWDAIQLEDLDIDRDEITVVNCLYRAENLHDESVKVESCRDTVLNLIGKINPDLFVFGIVNGAYNAPFFVTRFREALFHFSSIFDMLETIVPREDEERMFLEMEVFGREALNVIACEGWERVERPETYKQWHVRAMRSGLVQVPFDPSIMKTSLHKVHTFYHKDFVIDQDNRWLLQGWKGRTVMALSVWKPESKA
Protein: tRNase Z TRZ3, mitochondrial (EC 3.1.26.11) (Long tRNase Z 1) (tRNase ZL1) (AthTRZL1) (Q8VYS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Can process the mitochondrial tRNA-like structures (t-elements). Involved in the processing of small nucleolar RNAs (snoRNAs).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19411372}. Nucleus {ECO:0000269|PubMed:19411372}.
Interaction partners:
- tRNase Z TRZ1
- tRNase Z TRZ2, chloroplastic
- tRNAse Z TRZ4, mitochondrial
- Dynamin
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- 2'-phosphotransferase
- ATP-dependent
- Omega-amidase, chloroplastic
- Glycine--tRNA ligase, mitochondrial 1
- Xaa-Pro dipeptidase
Sequence:
MINSMPYLHKNLRLLRLLSSKSSPFPLSLRPFSPRSFSLSTLFSSSSSSSSMENNEATNGSKSSSNSFVFNKRRAEGFDITDKKKRNLERKSQKLNPTNTIAYAQILGTGMDTQDTSSSVLLFFDKQRFIFNAGEGLQRFCTEHKIKLSKIDHVFLSRVCSETAGGLPGLLLTLAGIGEEGLSVNVWGPSDLNYLVDAMKSFIPRAAMVHTRSFGPSSTPDPIVLVNDEVVKISAIILKPCHSEEDSGNKSGDLSVVYVCELPEILGKFDLEKAKKVFGVKPGPKYSRLQSGESVKSDERDITVHPSDVMGPSLPGPIVLLVDCPTESHAAELFSLKSLESYYSSPDEQTIGAKFVNCIIHLSPSSVTSSPTYQSWMKKFHLTQHILAGHQRKNMAFPILKASSRIAARLNYLCPQFFPAPGFWPSQLTDNSIIDPTPSNKCSSSNLAESISAENLLKFNLRPVAIRGIDRSCIPAPLTSSEVVDELLSEIPEIKDKSEEIKQFWNKQHNKTIIEKLWLSECNTVLPNCLEKIRRDDMEIVILGTGSSQPSKYRNVSAIFIDLFSRGSLLLDCGEGTLGQLKRRYGLDGADEAVRKLRCIWISHIHADHHTGLARILALRSKLLKGVTHEPVIVVGPRPLKRFLDAYQRLEDLDMEFLDCRSTTATSWASLESGGEAEGSLFTQGSPMQSVFKRSDISMDNSSVLLCLKNLKKVLSEIGLNDLISFPVVHCPQAYGVVIKAAERVNSVGEQILGWKMVYSGDSRPCPETVEASRDATILIHEATFEDALIEEALAKNHSTTKEAIDVGSAANVYRIVLTHFSQRYPKIPVIDESHMHNTCIAFDLMSINMADLHVLPKVLPYFKTLFRDEMVEDEDADDVAMDDLKEEAL
Protein: Selenide, water dikinase (EC 2.7.9.3) (Selenium donor protein) (Selenophosphate synthase) (P16456)
Organism: Escherichia coli (strain K12)
Function: Synthesizes selenophosphate from selenide and ATP.
Interaction partners:
- L-seryl-tRNA
- tRNA 2-selenouridine synthase
- Selenocysteine-specific elongation factor
- Cysteine desulfurase
- Thioredoxin reductase
- Cysteine desulfurase IscS
- Formate dehydrogenase H
- DNA topoisomerase 3
- Uncharacterized protein YqeB
- Serine--tRNA ligase
Sequence:
MSENSIRLTQYSHGAGCGCKISPKVLETILHSEQAKFVDPNLLVGNETRDDAAVYDLGNGTSVISTTDFFMPIVDNPFDFGRIAATNAISDIFAMGGKPIMAIAILGWPINKLSPEIAREVTEGGRYACRQAGIALAGGHSIDAPEPIFGLAVTGIVPTERVKKNSTAQAGCKLFLTKPLGIGVLTTAEKKSLLKPEHQGLATEVMCRMNIAGASFANIEGVKAMTDVTGFGLLGHLSEMCQGAGVQARVDYEAIPKLPGVEEYIKLGAVPGGTERNFASYGHLMGEMPREVRDLLCDPQTSGGLLLAVMPEAENEVKATAAEFGIELTAIGELVPARGGRAMVEIR
Protein: RRM domain-containing protein (Q9VPK4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Zinc finger CCHC domain-containing protein 8 homolog
- RNA helicase
- Combover, isoform A
- Uncharacterized protein, isoform D
- Zinc finger CCHC domain-containing protein 7
- Uncharacterized protein, isoform B
- Uncharacterized protein, isoform A
- Uncharacterized protein, isoform B
- RT01008p
- LD45152p
Sequence:
MDLQLLMQQMYSGASVMTISETNIDGYRYGIPSGQHQEQPIYPFLPNENGDQLVGQLEDDDDEEEDEEQRTLFCGNLDERVTEEILYEVFLQAGPIEGVRIPTDNNGRPRNFGFVTYQRLCAVPFALDLYQGLELFQKKVTIKQQGGKQLPAYNQSRLRNQFMMEALPQPSPLRHARHSLHNGKPYDRNPFGHNADQRRRSDSSVMERNRLKPQQHHQHMQGGSRRSDQRSNNKRRLL
Protein: Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] (Q01177)
Organism: Rattus norvegicus (Rat)
Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
Subcellular location: Secreted {ECO:0000250}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). {ECO:0000250}.
Interaction partners:
- Histidine-rich glycoprotein
- Annexin A2
- Serpin family F member 2
- Tissue-type plasminogen activator
- Fibrinogen alpha chain
- Aa1018
- Antithrombin-III
- Albumin
- Protein S100-A10
- Complement C3
Sequence:
MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEYCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND
Protein: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (Alpha 2,3-ST 2) (Beta-galactoside alpha-2,3-sialyltransferase 2) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (ST3Gal II) (ST3GalII) (ST3GalA.2) (Sialyltransferase 4B) (SIAT4-B) (Q11204)
Organism: Mus musculus (Mouse)
Function: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q16842}; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (By similarity). Secreted into the body fluid. {ECO:0000250|UniProtKB:Q16842}.
Interaction partners:
- Beta-1,3-galactosyltransferase 4
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
- Beta-1,3-galactosyltransferase 5
- Galactoside alpha-
- Galactoside alpha-
- Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
- C1GALT1-specific chaperone 1
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Sequence:
MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGALGGTHRVKLVPGYSGLQRLGKEGLLGRNCACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
Protein: Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) (Q63789)
Organism: Rattus norvegicus (Rat)
Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Interaction partners:
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Receptor protein-tyrosine kinase
- Insulin receptor substrate 1
- Platelet-derived growth factor receptor beta
Sequence:
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPVTSAVTNGMKDCFVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGNYGFSEPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKSEDTDESYFINEDDESLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKPCVIYSPARGYGFAEPYNLYGSLKELVLHYQQTSLVQHNDSLNVTLAYPVHAQMPSLCR
Protein: mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (O74880)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Responsible for methylating the 5'-cap structure of mRNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable cyclin-dependent kinase 9
- mRNA-capping enzyme subunit alpha
- Transcription elongation factor spt5
- General transcription and DNA repair factor IIH subunit tfb4
- Cyclin pch1
- Rpb7-binding protein seb1
- Pre-mRNA-splicing factor 38
- Probable U2 small nuclear ribonucleoprotein B''
- Small nuclear ribonucleoprotein G
Sequence:
MSSSNSRVHEEQPPTENRRYARPTAQMNRVIEQQPRRRDYFQNNDNSGRRGYNRHENNGNAQDVVRSHYNARPDLGYKKRQFSPIIQLKRFNNWIKSVLIQKFAPHASDYPILVLDMGCGKGGDLIKWDKAGIDGYIGIDIAEVSVNQAKKRYREMHASFDALFYAGDCFSSSINELLPPDQRKFDVVSLQFCMHYAFESEEKVRVLLGNVSKCLPRGGVMIGTIPNSDVIVKHIKMLKPGEKEWGNDIYKVRFPESPPRSFRPPYGIQYYFYLEDAVTDVPEYVVPFEAFRAVAEGYNLELIWVKPFLDILNEEKNSETYGPLMDRMKVVDNEGHRGIGGQEKEAAGFYLAFAFEKRGI
Protein: UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Q9TW62)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03172}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03172}.
Interaction partners:
Sequence:
MSVEKPKIVFVLGGPGAGKGTQCSRIVDRFQFTHLSAGDLLREERSREGSEFGNLIEDYIRNGKIVPVEVTCSLLENAMKASGKSRFLIDGFPRNQDNLDGWNRQMSEKVDFQFVFFFDCGEDVCVKRCLGRGQSGSGRTDDNLDSLKKRISTYNNDSLPIIKFFEGAGQVKRIDASPDAEEVFGEVEKIFVASGF
Protein: Juvenile hormone binding protein 5, isoform A (Juvenile hormone binding protein 5, isoform B) (Q9VEZ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNQYFLTGLLLVLGVVLHIDWTTAKPPAKKADQLPSFLKVCHRNAPDLDTCVRESYEELRPRLMEGIPELYIPAMEPLVVPQVKMDQDSGAIYLHSVYRNVKVTGISKHTVNELRLEPSKLKFILSLTFPKLHMESDYSIKGKIMMMPLLGDGHCKVDLVNITMRTELIGQEYKKNGANFLKINTVKVKYELSDVHIHLDNLFNGDKALGDRMNEFLNENWKALAEEVRPLMTKALVDILRASVDKLFASFSYDDLLPM
Protein: Protein lin-15B (Abnormal cell lineage protein 15B) (Q27395)
Organism: Caenorhabditis elegans
Function: Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity.
Interaction partners:
- 3'-5' exonuclease eri-1
- Protein lin-15A
- Protein lin-36
- Systemic RNA interference defective protein 1
- Retinoblastoma-like protein homolog lin-35
- Zinc finger protein lin-13
- RNA-directed RNA polymerase
Sequence:
MQTLKTARLTSNPASIPTSSSSSAISAAAIQKTLDAVNRPPAVRASGILRHRTLPAPTQETAHHLDADPKTTELMARFFISQGIPFECAHEPAFLELMKHVDPNCVIPPTNVTKKLVDKISTSSKPQVNYTKTVGPLSVTIDICGDEDEKYLAFSIHYFEDLYERKNAIYLRKLLLTELDSNSLLTNIRRSVNSYSFSNVKFTNIVCPNEEICKLVEESAVVKRYNVCFYNYVTRFVADLMEIEEFSSGLTQLRTFVRYMKQNSDMYSKFRRMQLQKNAELDIPSIDSGDWHSTAIFLTRCLVWHDTFTEFCGKLDILHYIDNETFNHLIYLQRLLQQCMKHCRELSIPNNSISQVVPAIMSIRNFIASNSMGYRFQKRIRDSFTTSFKEITSGPSQDRYDIATLLDPRFAYRDTVYTAQTWRSLEKKVIDDFVNSDLQNDKNFYQDISILNQEQRYDIIKKEFAYYRQTSFVERPEENENSNHWWGMRQTDMEFLAVIAREYLASPAVSIDAGYYFGNGGKFQHICHTYSHQRLENCLALAGNYQTFRGKGASVDVISQSMIETLNNTASRLQKQVHLGLYAHGVDNISSDRDVQSIVGHHYPPMPTVANYDIPHVPKEEEKPPVANLQSTSSPATSSPTIIRPRAAPPPRTLAQGRPIPLNGKELKAVPIRQIPLQVRPLPPRPANVPIVPRPTVPQQFIKAPAPKPITLQAVVCSIPEKEIKKETEDVALLEKIKDEPLDEDDFNHPSTDPVPNRTTASSQGPSSYPRKIVVLASKLPTSQSSSPSTATSAQARSHVTTAQLIRCGPSEGTVPQKIHSHNFVQKFAQKQNFVHKYALNSQDHTGRLNQTVPMRAALRLPNSEQKSGAPSSINGKVQRDDFKLEPLDDFNGEPDYDNLIGAQRLMYSDNLNDASAEDAFARHRVTMEFQKRRACNRRCAVCGHLEIHERLKNVTIENEKLLIMLGCIYRGEFTLGQAQLFMARESKTYICRLHFLETLDEIYQMLRLKSADDILICPLDLIQNALITVSALRPHIIASQLRKILHDFAERNNHLRETPAELKKLGQQYFDYREPEPEPERNDVDEQEIIPKLFRQPRKQVLEADQHDGTVKVIEQEDFKLPTVKPSENEECDNPGVCCFCSKRGDRGGMLRVPRSEERLARWVDKLGPEFEARLHTNTENLICRSHFPDAAFSSRGRLLKGMIPDAAPEKVETTYIIQGNNFLKLKERKSGTDKNSAIDLANMLNPDGVEYTQEEEEEEEYEEMSRSPTEETSDDEPSQAAVYNNAPVIKRTYRKRELSNEDGPLNLVTPPAHTPNPRGRPRKYPKNSVTPEAEKSLTDYDYNPGTSQRRALKKGYVQLEDGEIVGEDCEYVPEKTPSGRLIRQAVARRSFAFADEEEEEEEYEESPIVKKPKIAGRPVGRPRKDANKLPTPTPPSNE