wanglab/gogpt-training-data huggingface dataset:
Protein: Polypeptide N-acetylgalactosaminyltransferase 15 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 2) (GalNAc-T-like protein 2) (pp-GaNTase-like protein 2) (Polypeptide N-acetylgalactosaminyltransferase-like protein 2) (Protein-UDP acetylgalactosaminyltransferase-like protein 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2) (Q8N3T1)
Organism: Homo sapiens (Human)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
Sequence:
MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLDFGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVHILSGKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER
Protein: FGFR1 oncogene partner 2 homolog (Wound-inducible transcript 3.0 protein) (Wit3.0) (Q6TA25)
Organism: Rattus norvegicus (Rat)
Function: May be involved in wound healing pathway underlying the favorable early wound closure characteristics of oral mucosa. Accelerates the collagen gel contraction in vitro.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- TRAF3-interacting protein 3.
- Striatin-interacting protein 1
- Striatin-3
- Suppressor of IKBKE 1
- Programmed cell death protein 10
- Serine/threonine-protein kinase 24
- Serine/threonine-protein kinase 25
- Sarcolemmal membrane-associated protein
- MOB-like protein phocein
- Striatin interacting protein 2
Sequence:
MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALSKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNSCEGFFLDASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLSALVTNSDLSLRKS
Protein: Leucine-rich repeat receptor-like protein kinase (Leucine-rich repeat transmembrane protein kinase family protein) (Receptor protein kinase-like) (Q9FGN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- WUSCHEL-related homeobox 4
- CLAVATA3/ESR
- CLAVATA3/ESR
- WUSCHEL-related homeobox 14
- Dof zinc finger protein DOF5.6
- Transcription factor LHW
- Homeobox-leucine zipper protein ATHB-8
Sequence:
MASSKHNKLCSFFYLCLFLTLVAAAEPQTESLLTLKSQLTDNFNSLKDWFINTPEVSDNLVACCSWSGVRCNQNSTSVVSVDLSSKNLAGSLSGKEFLVFTELLELNISDNSFSGEFPAEIFFNMTNLRSLDISRNNFSGRFPDGNGGDSSLKNLIFLDALSNSFSGPLPIHLSQLENLKVLNLAGSYFTGSIPSQYGSFKNLEFLHLGGNLLSGHIPQELGNLTTLTHMEIGYNSYEGVIPWEIGYMSELKYLDIAGANLSGFLPKHFSNLTKLESLFLFRNHLSREIPWELGEITSLVNLDLSDNHISGTIPESFSGLKNLRLLNLMFNEMSGTLPEVIAQLPSLDTLFIWNNYFSGSLPKSLGMNSKLRWVDVSTNSFQGEIPQGICSRGVLFKLILFSNNFTGTLSPSLSNCSTLVRIRLEDNSFSGVIPFSFSEIPDISYIDLSRNKLTGGIPLDISKATKLDYFNISNNPELGGKLPPHIWSAPSLQNFSASSCSISGGLPVFESCKSITVIELSNNNISGMLTPTVSTCGSLKKMDLSHNNLRGAIPSDKVFQSMGKHAYESNANLCGLPLKSCSAYSSRKLVSVLVACLVSILLMVVAALALYYIRQRSQGQWKMVSFAGLPHFTADDVLRSFGSPEPSEAVPASVSKAVLPTGITVIVRKIELHDKKKSVVLNVLTQMGNARHVNLVRLLGFCYNNHLVYVLYDNNLHTGTTLAEKMKTKKKDWQTKKRIITGVAKGLCFLHHECLPAIPHGDVKSSNILFDDDKIEPCLGEFGFKYMLHLNTDQMNDVIRVEKQKDVYNFGQLILEILTNGKLMNAGGLMIQNKPKDGLLREVYTENEVSSSDFKQGEVKRVVEVALLCIRSDQSDRPCMEDALRLLSEAENRFK
Protein: Protein BEARSKIN1 (NAC domain-containing protein 15) (ANAC015) (Q9C878)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator. Together with SMB and BRN2, regulates cellular maturation of root cap. Promotes the expression of genes involved in secondary cell walls (SCW) biosynthesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein RESPONSE TO ABA AND SALT 1
- AT-hook motif nuclear-localized protein 11
- Transcription factor MYB87
- LOB domain-containing protein 3
- LOB domain-containing protein 4
- At3g10000
Sequence:
MSSSNGGVPPGFRFHPTDEELLHYYLKKKISYEKFEMEVIKEVDLNKIEPWDLQDRCKIGSTPQNEWYFFSHKDRKYPTGSRTNRATHSGFWKATGRDKCIRNSYKKIGMRKTLVFYKGRAPHGQKTDWIMHEYRIEDTEDDPCEDGWVVCRVFKKKNLFKVGNDVGSNISNNRLEARSFIRRESPYQGISMFELNKPEEISVHQYPQPPMFQPHHKPLSIGYDYSLALLPRESEYQQACQPSGVEVGTCKAVSEWGIVNCNMVSHEDSSRAMRFEDDGNNTSSTVQPPSNLLSLRGENGFLGLF
Protein: AT3g27090/MOJ10_18 (DCD (Development and Cell Death) domain protein) (Q9LSC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nodulin-related protein 1
- Putative NAC domain-containing protein 94
- Plant UBX domain-containing protein 12
- Putative plant UBX domain-containing protein 15
Sequence:
MDSFWQLGDELRGQTRASEDHKWSTVATKLAEQTRMKGERMNNLDLSKGYTEFRPSEKFSFQENNLNFNMLNLDGKFGESIMGKTSMQSNVYNMNTVFQKNDFKSGGNMKVNKYNGNVVANKEMSNNKHNNNCNDNGNMNLAVDKRFKTLPASETLPRNEVLGGYIFVCNNDTMQEDMKRHLFGLPPRYRDSVRAITPGLPLFLYNYTTHQLHGIFEATTFGGTNIDATAWEDKKCKGESRFPAQVRIRVRKICKALEEDSFRPVLHHYDGPKFRLELSVPETLDLLDLCEQAGSA
Protein: Lectin alpha chain [Cleaved into: Lectin beta chain; Lectin gamma chain] (P08902)
Organism: Dioclea grandiflora (Mucana)
Function: D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.
Interaction partners:
Sequence:
ADTIVAVELDSYPNTDIGDPNYPHIGIDIKSIRSKSTARWNMQTGKVGTVHISYNSVAKRLSAVVSYSGSSSTTVSYDVDLNNVLPEWVRVGLSATTGLYKETNTILSWSFTSKLKTNSIADENSLHFSFHKFSQNPKDLILQGDAFTDSDGNLELTKVSSSGDPQGNSVGRALFYAPVHIWESSAVVASFDATFTFLIKSPDREPADGITFFIANTDTSIPSGSGGRLLGLFPDAN
Protein: Stomatin (A0A8I5YCP1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MWRICLPCGTVTRYNSKAELGPCGWILVAVSFIFVLITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIMGSHH
Protein: propionyl-CoA carboxylase (EC 6.4.1.3) (Q553S7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Propionyl-CoA carboxylase beta chain, mitochondrial
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Methylmalonyl-CoA epimerase, mitochondrial
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Peroxisomal acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase
- acetyl-CoA C-acyltransferase
- Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Sequence:
MNRLFKVQSVISKPVGWSSIRSFHSSSANYMFEKILIANRGEIACRVMETCKKMGIKTVAIHSDVDKNAKHVNMADEAICVGPAPTSESYLNIDAIVEAIKMTGAQAVHPGYGFLSENSRFVKELENIGVTFIGPGSYAMHALGDKIESKRIAKEAGVSVVPGYIGEVDGMDHVIKIANEIGYPVMVKASAGGGGKGMRVCRNDEDVKIGFRLSKQEAKSSFGDDRMLIEKYIEHGRHIEIQVLSDGENALYFPERDCSIQRRNQKVIEEAPSPFMDEETRTKMGKEAAALCKAVGYKSAGTVEFLVDHDKSFYFLEMNTRLQVEHPITEEITKQDLVEHMIRIAYGEKLKIKQSDIKIHGWAMESRVYAEDPYRNFLPSIGRVKKYIRPSGPGIRIDGGIFEGAEISTYYDPLISKLITYGENRKNVITKMKRALDEYYIKGVNHNVAFLRDVMENKDFVDGNVTTDFIPKEYPEGFQGYKFSPKQIEQLSICAVFLRFVEQHKNLTNSSNTNRTSSISPDILYIAKVENVRHSIHFYPLDNSETDAAANGANGDDSSRFMVQFIDQEKDGQVIKEFELNLVDATPQFIKLNIGGISHRFQIHDKTSTSYTLQFHGSKIPVTVLSPEEDLLCQYMPVKKTVDSSNSLISPMPGTILSLAVNVGDKVVLGQELCIVEAMKMQNVLRAPKDCEIKSINVKPGQVVSVDEVLIDFK
Protein: Membrane metalloprotease ARASP, chloroplastic (EC 3.4.24.-) (O80885)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Metalloprotease essential for chloroplast and plant development. May be involved in regulated intramembrane proteolysis (RIP).
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:16413549}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP-dependent protease La
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 4, chloroplastic
- Clp protease adapter protein ClpF
- ATP-dependent Clp protease ATP-binding subunit CLPT2
- ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic
- Protease Do-like 5, chloroplastic
- Chaperone protein ClpC2, chloroplastic
- Protein ASPARTIC PROTEASE IN GUARD CELL 1
Sequence:
MLLNISSSPISHRNPHFLSNFNNPISYFPRRSKTHLSKSHFFPKFTPLSNQSLKNRVLFGNKRYPDGERFDFRSRAISGIDLGSFESVLEAIAVLTTIIVVHESGHFLAASLQGIHVSKFAIGFGPILAKFDYNNVEYSLRAFPLGGFVGFPDNDPDSEIPIDDENLLKNRPTLDRSIVVSAGIIANVIFAYAIIFVQVLSVGLPVQEAFPGVLVPEVKTFSAASRDGLLSGDVILAVDGTELSKTGPDAVSKIVDIVKRNPKSNVVFRIERGGEDFDIRVTPDKNFDGTGKIGVQLSPNVRITKVRPRNIPETFRFVGREFMGLSSNVLDGLKQTFFNFSQTASKVAGPVAIIAVGAEVARSNIDGLYQFAALLNINLAVINLLPLPALDGGTLALILLEAVRGGKKLPVEVEQGIMSSGIMLVIFLGLFLIVKDTLSLDFIKEML
Protein: THO complex subunit 4A (ALYREF homolog 1) (AtALY1) (Q8L773)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Export adapter involved in nuclear export of spliced and unspliced mRNA.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:15299117}. Nucleus, nucleolus {ECO:0000269|PubMed:15299117}.
Interaction partners:
- RNA-binding protein Y14
- Protein mago nashi homolog
- DEAD-box ATP-dependent RNA helicase 15
- THO complex subunit 2
- THO complex subunit 3
- THO complex subunit 5B
- THO complex subunit 5A
- THO complex subunit 1
- Histone deacetylase complex subunit SAP18
- DEAD-box ATP-dependent RNA helicase 56
Sequence:
MSTGLDMSLDDMIAKNRKSRGGAGPARGTGSGSGPGPTRRNNPNRKSTRSAPYQSAKAPESTWGHDMFSDRSEDHRSGRSSAGIETGTKLYISNLDYGVMNEDIKELFAEVGELKRYTVHFDRSGRSKGTAEVVYSRRGDALAAVKKYNDVQLDGKPMKIEIVGTNLQTAAAPSGRPANGNSNGAPWRGGQGRGGQQRGGGRGGGGRGGGGRGRRPGKGPAEKISAEDLDADLDKYHSGDMETN
Protein: RB binding protein 4, chromatin remodeling factor (H0YDK2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMMVSHFFTQAGVQWCNLGSLQLPPPRFDRFSCLSLLSSWDYRQRTFIMMKTLKEAWIQKDKGPRYVFTCCDFRLPFFLLNPESDLTLVLRQTLFSYPSI
Protein: Integrator complex subunit 13 (F5H457)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKE
Protein: Leukocyte elastase inhibitor A (Serine protease inhibitor EIA) (Serpin B1a) (Q9D154)
Organism: Mus musculus (Mouse)
Function: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of granzyme H. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. In addition, promotes the proliferation of beta-cells when secreted.
Subcellular location: Secreted {ECO:0000269|PubMed:26701651}. Cytoplasm {ECO:0000250|UniProtKB:P30740}. Cytolytic granule {ECO:0000250|UniProtKB:P30740}. Early endosome {ECO:0000250|UniProtKB:P30740}.
Interaction partners:
- Albumin
- Thyroglobulin
- T-cell surface glycoprotein CD4
- Interleukin-4
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-5
- Interferon gamma
- Interleukin-13
- H-2 class II histocompatibility antigen, A beta chain
- Toll-like receptor 4
Sequence:
MEQLSSANTLFALELFQTLNESSPTGNIFFSPFSISSALAMVILGAKGSTAAQLSKTFHFDSVEDIHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEYLASTQKMYGADLAPVDFLHASEDARKEINQWVKGQTEGKIPELLSVGVVDSMTKLVLVNAIYFKGMWEEKFMTEDTTDAPFRLSKKDTKTVKMMYQKKKFPFGYISDLKCKVLEMPYQGGELSMVILLPKDIEDESTGLKKIEKQITLEKLLEWTKRENLEFIDVHVKLPRFKIEESYTLNSNLGRLGVQDLFSSSKADLSGMSGSRDLFISKIVHKSFVEVNEEGTEAAAATGGIATFCMLLPEEEFTVDHPFIFFIRHNPTSNVLFLGRVCSP
Protein: Acyl carrier protein 2, mitochondrial (MtACP-2) (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (O80800)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- NADH dehydrogenase flavoprotein 2, mitochondrial
- 2Fe-2S ferredoxin-like superfamily protein
Sequence:
MAARGAMLRYLRVNVNPTIQNPRECVLPFSILLRRFSEEVRGSFLDKSEVTDRVLSVVKNFQKVDPSKVTPKANFQNDLGLDSLDSVEVVMALEEEFGFEIPDNEADKIQSIDLAVDFIASHPQAK
Protein: Homocysteine synthase (EC 2.5.1.49) (O-acetylhomoserine sulfhydrylase) (OAH SHL) (OAH sulfhydrylase) (O13326)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Can also use O-succinyl-L-homoserine and L-homoserine as substrates. Has also cysteine synthase (O-acetylserine sulfhydrylase) activity in vitro, but in S.pombe, it seems only to be involved in the alternative pathway of methionine biosynthesis under cysteine deficiency conditions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cysteine synthase 1
- Cysteine synthase 2
- Probable sulfite reductase flavoprotein component
- Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Sulfide:quinone oxidoreductase, mitochondrial
- Sulfite reductase subunit beta
- Putative serine acetyltransferase
- Probable cystathionine gamma-synthase
- Cystathionine beta-lyase
- Homoserine O-acetyltransferase
Sequence:
MPVESEHFETLQLHAGQEPDAATSSRAVPIYATTSYVFRDCDHGGRLFGLQEPGYIYSRMMNPTADVFEKRIAALEHGAAAIATSSGTSALFMALTTLAKAGDNIVSTSYLYGGTYNLFKVTLPRLGITTKFVNGDDPNDLAAQIDENTKAVYVESIGNPMYNVPDFERIAEVAHAAGVPLMVDNTFGGGGYLVRPIDHGADIVTHSATKWIGGHGTTIGGVIVDSGKFDWKKNSKRFPEFNEPHPGYHGMVFTETFGNLAYAFACRTQTLRDVGGNANPFGVFLLLQGLETLSLRMERHVQNAFALAKYLEKHPKVNWVSYPGLESHVSHKLAKKYLKNGYGAVLSFGAKGGPDQSRKVVNALKLASQLANVGDAKTLVIAPAYTTHLQLTDEEQISAGVTKDLIRVAVGIEHIDDIIADFAQALEVA
Protein: CUB-like domain-containing protein (Q93765)
Organism: Caenorhabditis elegans
Interaction partners:
- CUB_2 domain-containing protein
- CUB-like domain-containing protein
- Uncharacterized protein
- VWFA domain-containing protein
- Serpentine Receptor, class R
- Fatty Acid/Retinol binding protein
- C-type LECtin
- C-type lectin domain-containing protein
Sequence:
MISFVLFSILFIAPSFADDLTCPNSPITSNVPSGHFPLNGLAKFPANYDCSVEFEIPDGQVIKFIVQTDALFENLDSFVIRDSRSTLYKMDVGESVFFAAANNSKVYISTNSGKASFYFSWQYIDVSKFTRIQNPTGTVLNLNLTANSFYQFVSSADQVAFHTSALGILSDSSIWKIYVYDGEDLNAKFMGNLKQFTNIGSSSTRKSLSLVNFYETPSQSYGIANDYSIVSRYKDYSLRILSSGSDFFERFFVPDGVKSAVTFFCPDSMETYITGLTIVKQNFPGEKFVSFTPLTPTHAYSNVLAYSVGDPIYRSLPQQILSDTFTMVAYQSAVSLSLTCGPYPNWGYVFPGRRGYIISPSIWNPTTLKTPSYSTNFTSSETVRFNINLPDVVIGDPGAKIRVEFGAPGKTPVGVEFNETTSGAGARSANATYMSVTFDGTTVKSSFSFVFNVESLFPSTSTTTDTPFETTTKSSAIIFKCSMVFIILVKFLNF
Protein: RhoGAP1A (Q6W453)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLK
Protein: Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331) (P16092)
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Fibroblast growth factor 2
- Fibroblast growth factor 4
- Beta-klotho
- Fibroblast growth factor 1
- Fibroblast growth factor 18
- Fibroblast growth factor 10
- Fibroblast growth factor 22
- Klotho
- Fibroblast growth factor 9
- Fibroblast growth factor 3
Sequence:
MWGWKCLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMLGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPTQLANSGLKRR
Protein: Sodium-dependent lysophosphatidylcholine symporter 1-A (NLS1-A) (Sodium-dependent LPC symporter 1-A) (Major facilitator superfamily domain-containing protein 2A-A) (Q5U3U7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9DA75}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9DA75}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MARGEGAEQFSSGLLPTAKSVTQNEIKMVKLPKQQERKRALTVWSKVCFAIGGAPYQITGTALGFFLQIFLLDVAQLNPLNASVILFVGRAWDAVTDPTVGFLVSRTPWTRHGRMMPWILVSTIPAVLCYFLIWVVPPIEQGKMMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQRERDSATAYRMTVEVFGTVVGTAIQGQIVGMANTPCKNNTSPNNSSNDLIQSNNSHIPLKSNIFDERCAYMIASAVISLIYVVCAAVLFFGVREQDVQGELKAQKRVSFQKGLRLVMGHGPYVKLVLAFLFTSLAFMLLEGNFAVFIKYTLGFREDFQNILLVIMVSATVSIPMWQWFLCRFGKKTAVYIGITWAVPFMILVVSVNSSLIVSYIVSIAAGVSVGAAFLLPWSMLPDVVDDFKLQNPTSQGHEAIFYSFYVFFTKFASGVSLGVSTLALSFAGYETGVCVQSDSVNLTLKLLVSAAPVSLIALGLLIFMTYPIDEERREYNNKQLQLLLRNEEEEDEMEVLKPDITA
Protein: Homeodomain interacting protein kinase 2 (H7BXX9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKHTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPGNLGPGQGRNLSLESGFPAFLLLEMLLYGS
Protein: Casein kinase II subunit alpha-2 (OsCKA2) (EC 2.7.11.1) (Protein HEADING DATE 6) (Q9AR27)
Organism: Oryza sativa subsp. indica (Rice)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins (By similarity). Involved in photoperiod sensitivity (PS). Increases days-to-heading under natural day (ND) and long day (LD) conditions, but not under short day (SD) conditions.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P48730}.
Interaction partners:
Sequence:
MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTEALNAYLNKYHIELDPQLEALVGRHSRKPWSKFINADNQHLVSPEAVDFLDKLLRYDHQDRLTAREAMAHPYFLQVRAAENSRARPQ