wanglab/gogpt-training-data huggingface dataset:
Protein: GH11964p (Q961P7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGKHDPKVTHDTPAPGDYHPEKVRLDHNPAFSFAGRHDLHKPSETPAPGDYFPEKVRQDFNPAFTFAGKHDPRSLSESPAPGDYSPEKVRLDHAPAFSFGGKHDPKTEHLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAPCDYHPEQCQVDSTPAFTFGMRLGRERISDTPAPSAYEPEKHSLHSTPAYSFGTKSDIRVTTDAPAPGHYHPEQCKLDSSPAYSFGLKTVPTASLPEPRGAYIEDRIVQRRERRLASPVRNNAECTTTTTNHTNNNAGSSTTTTTTTTTTTKTFINGVEQPELQKKETTKQVNGTHKELKSAPQAPLSNGNIVSNGNHSKMVSTTTRIQEVAHGQKESGNLKVVASGKSDASATKAAAVSHQTVVQADGAIVTSGQSSRMQTVKYAVEASSVQEKIISS
Protein: Complement C1q and tumor necrosis factor-related protein 9 (Q4ZJN1)
Organism: Mus musculus (Mouse)
Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
Subcellular location: Secreted {ECO:0000269|PubMed:18787108}.
Interaction partners:
Sequence:
MRIWWLLLVMGACTRSVFSQDTCRQGHSGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGPKGSIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPMGPIGKPGPRGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPLVPKSAFTVGLTVISKFPPPDAPIKFDKILYNELNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHTKDSYMSSEDQASGGIVQELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (Sucrose nonfermenting protein 2-like 1) (B2ZFP3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed primase/polymerase protein
- Replication protein A3.
- Replication protein A 70 kDa DNA-binding subunit
- RPA1-related single stranded DNA-binding protein.
- WRN RecQ-like helicase.
- FA complementation group M.
- Helicase ATP-binding domain-containing protein.
- Integrator complex assembly factor WDR73
- Structure-specific endonuclease subunit MUS81
- DNA repair protein RAD51 homolog
Sequence:
MSVSLTPEQQRRIEENRKKALARRAERQAQIADPGPAQNKHTQSGTTGGPAKNNQHFASDRGQSGAPTRQTQLIDINAACTKTAPPTSITAASTASSFYGQAGKPSTGEKRPPKPPEPAANIPAKKPAVYLRGRCVSHSENRFRVEVGYHADLILVFKSIPSKNYDPATKMWNFSLEDYQMLMEQVAHLPSISLKPLEGMEGLNISASTCRPKDAAAMAALMRLCQGWQKPGATIKGKCVLVSRSRLEVDIGYQADVIGIFKQMPSKSYDMKTRKWTFLLEDYGKLMADLNELPTVETEPLPHAVLQSFSSQFEKTQSQAPVPPEADLSHIDPQLTRSLMPFQRDGVNFAVSREGRLLLADDMGLGKTVQAICIAAYYRSEWPLLVVAPSSVRFTWAEAFRRWLPSVKPDSINVVVKGKDSLRSGLINIISYDLLNKMDKQPPSSPFNVIIMDESHFLKNMKTARCRAALPLLKTAKRVILLSGTPAMSRPAELYTQIQAVRPALFPRFHDFGTRYCDAKQLPWGWDYSSSSNLTELKLLLEESLMLRRLKSEVLSQLPAKQRKVVTVTTDGINSRTKAALNAAARELAKGYHNKSQEKEALLVFFNHTAEAKIRAIMEYISDMLECGREKFLVFAHHKLVLDSITKELGEKSISFIRIDGSTPSAERQLLCERFQASQQSCVAVLSITAANMGLTLHSAALVVFAELFWNPGVLIQAEDRVHRIGQTSNVDIHYLVAKGTADDYLWPMIQAKMNVLEQVGLSESNISENAESASFHSRDRQQLTITEMFQRSFDEDEMLALMDQDP
Protein: Pre-mRNA-splicing factor RDS3 (Regulator of drug sensitivity 3) (Q06835)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for pre-mRNA splicing. Involved in regulation of drug sensitivity and may play a role in multidrug resistance.
Subcellular location: Nucleus {ECO:0000269|PubMed:14517302}.
Interaction partners:
- Pre-mRNA-splicing factor PRP21
- Pre-mRNA-splicing factor PRP11
- U2 snRNP component HSH155
- Pre-mRNA-splicing factor RSE1
- U2 snRNP component IST3
- Pre-mRNA-splicing helicase BRR2
- 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor BUD31
- RDS3 complex subunit 10
- Protein HSH49
Sequence:
MSRHQFDLIMCLKQPGVQTGLLCEKCDGKCPICDSYVRPKRKVRVCENCSFGKQAKNCIICNLNVGVNDAFYCWECCRLGKDKDGCPRILNLGSNRLDRHFEKKKKV
Protein: Envelope glycoprotein (GP1,2) (X5HMX4)
Organism: Zaire ebolavirus
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004402}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Virion membrane {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004650}. Virion membrane {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004563}.
Interaction partners:
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYASGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNGPKNISGQSPARTSSDPETNTTNEDHKIMASENSSAMVQVHSQGRKAAVSHLTTLATISTSPQPPTTKTGPDNSTHNTPVYKLDISEATQVGQHHRRADNDSTASDTPPATTAAGPLKAENTNTSKSADSLDLATTTSPQNYSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREVIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
Protein: Fibroblast growth factor (FGF) (A0A0R4IN60)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Beta-klotho
- Fibroblast growth factor receptor 4
- Klotho
- Fibroblast growth factor receptor 1-A
- LTO1 maturation factor of ABCE1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor 8
- Fibroblast growth factor receptor 3
- Nuclear receptor subfamily 1, group H, member 4.
- Fibroblast growth factor 23
Sequence:
MLLLLFVTVCGSIGVESLPLPDSGPHLANDWSEAVRLRHLYAARHGLHLQINTDGEISGSHMQSSDSLMEIWPVDTGCVAIKGVASSRFLCMERLGNLYGSHIYTKEDCSFLERILPDGYNVYFSSKHGALVTLSGAKNKLHSNDGTSASQFLPMINTLSEEHTKQHSGEQHSSVNHGQDHQLGLEIDSMDPFGKISQIVIQSPSFNKR
Protein: Protein DCG1 (P32460)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Allantoicase
- Allantoinase
- Ureidoglycolate lyase
- Allantoin permease
- Malate synthase 2
- Acyl carrier protein, mitochondrial
- Urea amidolyase
- Allantoate permease
- RNA polymerase I-specific transcription initiation factor RRN11
- Kynureninase
Sequence:
METRILVVNPNSSKSMTVSLRETIEKTFSMESCKISYFTGPDTSPPQIDGQETSIKSMEACLPLLIDDQESVYYFQKFNGILIACFSDHPLVAKIKDRAAKEKADVSIVGLLDSSINYCNLVGKKFSIITSNKEWIPILNNSVESKFLTGNTVNKNLWKGTVSTDLQVLDLHSPENFQQIAEIIYRENIKKLDSDIVILGCAGFSGLQNKLAKTFQRDGTLFLDTIEIGLQILITMIRFVNSQK
Protein: RNA-binding protein PIN4 (Psi inducibility protein 4) (P34217)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- General negative regulator of transcription subunit 2
- Serine/arginine
- [PSI+] induction protein 2
- Protein CAF40
- mRNA 3'-end-processing protein RNA14
- RuvB-like protein 2
Sequence:
METSSFENAPPAAINDAQDNNINTETNDQETNQQSIETRDAIDKENGVQTETGENSAKNAEQNVSSTNLNNAPTNGALDDDVIPNAIVIKNIPFAIKKEQLLDIIEEMDLPLPYAFNYHFDNGIFRGLAFANFTTPEETTQVITSLNGKEISGRKLKVEYKKMLPQAERERIEREKREKRGQLEEQHRSSSNLSLDSLSKMSGSGNNNTSNNQLFSTLMNGINANSMMNSPMNNTINNNSSNNNNSGNIILNQPSLSAQHTSSSLYQTNVNNQAQMSTERFYAPLPSTSTLPLPPQQLDFNDPDTLEIYSQLLLFKDREKYYYELAYPMGISASHKRIINVLCSYLGLVEVYDPRFIIIRRKILDHANLQSHLQQQGQMTSAHPLQPNSTGGSMNRSQSYTSLLQAHAAAAANSISNQAVNNSSNSNTINSNNGNGNNVIINNNSASSTPKISSQGQFSMQPTLTSPKMNIHHSSQYNSADQPQQPQPQTQQNVQSAAQQQQSFLRQQATLTPSSRIPSGYSANHYQINSVNPLLRNSQISPPNSQIPINSQTLSQAQPPAQSQTQQRVPVAYQNASLSSQQLYNLNGPSSANSQSQLLPQHTNGSVHSNFSYQSYHDESMLSAHNLNSADLIYKSLSHSGLDDGLEQGLNRSLSGLDLQNQNKKNLW
Protein: Peflin (Penta-EF hand domain-containing protein 1) (P53238)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Calcium-binding protein that is required for polar bud growth and cell wall abscission. Can also bind zinc ions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17640275}. Nucleus {ECO:0000269|PubMed:17640275}. Bud tip {ECO:0000269|PubMed:17640275}. Bud neck {ECO:0000269|PubMed:17640275}. Note=Accumulates at the site of bud emergence in G1 cells. In small budded G1 cells, localizes asymmetrically on the tip of the daughter cell and in the nucleus. At a later stage of the G1 phase, is found at the emerging bud cortex and localizes in the nucleus. In large budded G2/M cells, localizes preferentially at the bud neck between the dividing mother and daughter cells, with very weak signals in the nucleus. {ECO:0000269|PubMed:17640275}.
Interaction partners:
- Protein transport protein SEC31
- pH-response regulator protein palA/RIM20
- Calpain-like protease 1
- Nuclear rim protein 1
- Vacuolar-sorting protein BRO1
Sequence:
MCAKKLKYAAGDDFVRYATPKEAMEETRREFEKEKQRQQQIKVTQAQTPNTRVHSAPIPLQTQYNKNRAENGHHSYGSPQSYSPRHTKTPVDPRYNVIAQKPAGRPIPPAPTHYNNLNTSAQRIASSPPPLIHNQAVPAQLLKKVAPASFDSREDVRDMQVATQLFHNHDVKGKNRLTAEELQNLLQNDDNSHFCISSVDALINLFGASRFGTVNQAEFIALYKRVKSWRKVYVDNDINGSLTISVSEFHNSLQELGYLIPFEVSEKTFDQYAEFINRNGTGKELKFDKFVEALVWLMRLTKLFRKFDTNQEGIATIQYKDFIDATLYLGRFLPH
Protein: SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (E7F3T0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Growth factor receptor-bound protein 2
- Growth factor receptor-bound protein 2a
- Receptor protein-tyrosine kinase.
- Epidermal growth factor receptor precursor.
- Erb-b2 receptor tyrosine kinase 3b.
- Erb-b2 receptor tyrosine kinase 3a.
- Receptor protein-tyrosine kinase.
- Receptor protein-tyrosine kinase.
- Receptor protein-tyrosine kinase.
- Tyrosine-protein kinase receptor.
Sequence:
MEYVDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDIVVSTSGVSYTVRYMGCVEVLQSMRALDFNTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCLSSILGKSNLQFAGMTITLTVSTSSLNLMAIDCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKVVTPHDRMAPFDGSAWEEEEEDLAPPPEVPYYNNFPGKQPPPGGLVDMRTRPGHSTGPTLPYGQPSQNDIHKQPLPPLPVGVKDGGLFDDPSYVNVDKPRLPASAAANGNAHRDAFDMKPFDAALVVSGAVALPLAEQLQNEPWFHGPLSRRQAERLLTKDGDFLVRESGTTPGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSEVCLQQPVDRKA
Protein: AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (O08915)
Organism: Mus musculus (Mouse)
Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Subcellular location: Cytoplasm.
Interaction partners:
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Aryl hydrocarbon receptor
- Prostaglandin E synthase 3
- Aryl hydrocarbon receptor repressor
- Aryl-hydrocarbon-interacting protein-like 1
- Aryl hydrocarbon receptor nuclear translocator
- Mitochondrial import receptor subunit TOM20 homolog
Sequence:
MADLIARLREDGIQKRVIQEGRGELPDFQDGTKATFHFRTLHSDNEGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESPGTYQQDPWAMTDEEKAKAVPVIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALETRIRQKDEEDKARFRGIFSH
Protein: Arginine-fifty homeobox (A6NJG6)
Organism: Homo sapiens (Human)
Function: Transcription factor that acts as activator.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Tetra-peptide repeat homeobox protein 1
- Double homeobox protein B
- Double homeobox protein A
Sequence:
MRNRMAPENPQPDPFINRNYSNMKVIPPQDPASPSFTLLSKLECSGTVSAYCSLNLPGSTDPPTSASRVAATTAIRRRHKERTSFTHQQYEELEALFSQTMFPDRNLQEKLALRLDLPESTVKVWFRNRRFKLKKQQQQQSAKQRNQILPSKKNVPTSPRTSPSPYAFSPVISDFYSSLPSQPLDPSNWAWNSTFTESSTSDFQMQDTQWERLVASVPALYSDAYDIFQIIELYNLPDENEISSSSFHCLYQYLSPTKYQVGGQGSSLSIFAGPAVGLSPAQTWPNMTSQAFEAYSLTDSLEFQKTSNMVDLGFL
Protein: Elongator complex protein 3 (hELP3) (EC 2.3.1.311) (tRNA uridine(34) acetyltransferase) (Q9H9T3)
Organism: Homo sapiens (Human)
Function: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:22854966}. Nucleus {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:22854966}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22002106}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:22002106}. Nucleus {ECO:0000269|PubMed:22002106}.
Interaction partners:
- Elongator complex protein 4
- Elongator complex protein 5
- Elongator complex protein 1
- Elongator complex protein 2
- Elongator complex protein 6
- Diphthamide biosynthesis protein 3
- Protein KTI12 homolog
- Cytoplasmic tRNA 2-thiolation protein 1
- Histone acetyltransferase KAT2A
- Histone acetyltransferase KAT2B
Sequence:
MRQKRKGDLSPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRKIGYRLQGPYMVKMLK
Protein: Olfactory receptor 6B3 (Olfactory receptor OR2-2) (Q8NGW1)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSGENVTRVGTFILVGFPTAPGLQYLLFLLFLLTYLFVLVENLAIILTVWSSTSLHRPMYYFLSSMSFLEIWYVSDITPKMLEGFLLQQKRISFVGCMTQLYFFSSLVCTECVLLASMAYDRYVAICHPLRYHVLVTPGLCLQLVGFSFVSGFTISMIKVCFISSVTFCGSNVLNHFFCDISPILKLACTDFSTAELVDFILAFIILVFPLLATMLSYAHITLAVLRIPSATGCWRAFFTCASHLTVVTVFYTALLFMYVRPQAIDSRSSNKLISVLYTVITPILNPLIYCLRNKEFKNALKKAFGLTSCAVEGRLSSLLELHLQIHSQPL
Protein: SEMA6C protein (Q1RMY5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPRAPHFMPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLEDDAVAAELGLDFQRFLTLNRTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDVENCAVRGKLTDECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCPAHSSPLGRSLQVLRGSREAPPVPGPARGLPGPRPEKGGRREAPVVPEASPRRALLPPGRPERRPFQLLKGAVHGLQRGERPSPLGHELDALQDVSPPPRPAPPAFPTRRVSRGPFSPRVYLLTVFPPVLDRRVGGEKPVSSVSQHFRGSWRTPTPRSLPAKLP
Protein: Probable voltage-dependent anion-selective channel (Q21752)
Organism: Caenorhabditis elegans
Function: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules (By similarity). Plays a role in maintaining mitochondrial morphology.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21796}.
Interaction partners:
- Transmembrane GTPase fzo-1
- Mitochondrial import receptor subunit TOM20 homolog
- Serine/threonine-protein kinase pink-1, mitochondrial
- E3 ubiquitin-protein ligase parkin
- ADP/ATP translocase
- ADP/ATP translocase
- ADP/ATP translocase
- ADP/ATP translocase
- ADP/ATP translocase
- ADP/ATP translocase
Sequence:
MAPPTFADLGKSAKDLFNKGYNFGFLKIDSTTRAGDNKEVEFKSAASHNIGSGKLGGNLDVKYKIPQYGITLTEKWNTENQLGTVIEVNEQFGRGLKVTLDSLYAPHAGKRSGKVKLDWALPTARVTADVGVTSAPVINAAGVFSRDGWLIGAAATFDSSSNKLAATSLAFGHSTPQYTLHSFVINSTDFGASLYHKVASNVEVGTQLGWKVGGNGADYALATKYAPSRDLTVRAKVNSSSQVAVAATHSLSPALKLTLSTQFNLAANDAHKFGLGLEFDPSN
Protein: Somatotropin (E5Q3H3)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MTFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLTPVQYLSKVFTNNLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRYGESNCTI
Protein: BTB/POZ domain-containing protein (Q54EU5)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Heat shock protein
- Palmitoyl-protein thioesterase 1
Sequence:
MLSSMTDIRKRVTVFQNGKRVGGKAISLPKKWSEFLKIVSKKLNIPASRIYNEDGGEIDEIESIVAKEILYASCGEHFIHIPKDIGYFGQPTIPNPYLIGPSPPPNIFPFHNGGGSGGIDIVPSGSSSTNSTTTTTTTTSSSSSSSNTTTSPNNLLTSPSIVNTGVGGGGVNHNMIQLLGGNGCITGLSSCGAIINNNEWISLNVGGRIFSTTRSTIIRDKDSMLAKMFSESWDSAKDINGAYLIDRSPDYFTPILNYLRCGTIVIDESLNVEGVYQEARFFNITGMLDKLASLVERKSRSTDVFTRKDVISILLTSSSNSSLRCQGLNLAGVDLSKLDLRNINFKMTNFKETNLSKCNLDNALLQEADLSGANLTGASLRGSNLTGANLEDCILKGANFEDRGGQRATLENVNFKNASLEEANFSGANLRVCNFKSANLENCNFRGADLAGANLEKCNFRGANLHKANLIGVNLKGANFDIRTVSSR
Protein: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (A0A3B3IRL5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYTFLPFTKSGCTEDSGGGRGGGGDAPQCPLLGTASLHN
Protein: CHCH domain protein (F4KDN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g65720/F1E22_13
- Translocation protein SEC62
- Uncharacterized GPI-anchored protein At5g19250
- Proline-rich extensin-like family protein
- Fasciclin-like arabinogalactan protein 1
- 12S seed storage protein CRA1
- soluble epoxide hydrolase
Sequence:
MGRRSSGGRSAPRPRPAAARSPAPQPVHRAPPPAPAQASGGGGGMFSGIGSTIAQGMAFGTGSAVAHRAVDSVMGPRTIQHEAVEAASASAAPAGSAMLSSTCDIHAKAFQDVSFKSFSHAFTLSLYFCYRIRFVRILNCMIEFVLKHLNSFLSLLNVYIAQ
Protein: Eukaryotic translation initiation factor 4E-1 (eIF4E-1) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein) (C6ZJZ3)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). Key component of recessive resistance to potyviruses (e.g. soybean mosaic virus (SMV), bean common mosaic virus (BCMV) and watermelon mosaic virus (WMV), but not bean pod mottle virus (BPMV)).
Subcellular location: Nucleus {ECO:0000269|PubMed:31860775}. Cytoplasm {ECO:0000269|PubMed:31860775}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31860775}. Cytoplasm {ECO:0000269|PubMed:31860775}. Note=(Microbial infection) Binds to potyvirus viral genome-linked protein (VPg) in the nucleus and with potyvirus nuclear inclusion protein A (NIa-Pro) and nuclear inclusion protein B (NIb) in the cytoplasm. {ECO:0000269|PubMed:31860775}.
Interaction partners:
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
- MI domain-containing protein
- MI domain-containing protein
- MI domain-containing protein
- MI domain-containing protein
- CYRIA/CYRIB Rac1 binding domain-containing protein
- CYRIA/CYRIB Rac1 binding domain-containing protein
Sequence:
MVVEDTQKSVITEDQYPSRVVSDNNNDDDDDDLEEGEIPVDGEDSGATATTKPPAALARNPHPLENSWTFWFDNPSSKSKQAAWGSSIRPIYTFATVEEFWSIYNNIHHPSKLGLGADFHCFKHKIEPKWEDPICANGGKWTMTFPRGKSDTSWLYTLLAMIGEQFDHGDEICGAVVNVRSRQDKIAIWTKNASNEAAQVSIGKQWKEFLDYNDTIGFIFHEDAKKLDRGAKNKYVV
Protein: Transcription factor Sp5 (Q9JHX2)
Organism: Mus musculus (Mouse)
Function: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAAPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPAPAPDDLPWWSIPQSGAGPGSSGVPGTSLSSACAGPPHAPRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKRENPRDL
Protein: Insulin receptor (Q6PVY2)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
ESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFIPRPSRKRRALGDVGNVTAAVPTALGLPNTSSTSTPMSSEEHRPFEKVVNXESLVISGLRHFTGYRIELQACNQDSPEER
Protein: DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) (Q13216)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ).
Subcellular location: Nucleus {ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:32355176}. Chromosome {ECO:0000269|PubMed:32355176}. Nucleus matrix {ECO:0000269|PubMed:26620705}. Note=Recruited to lesion-stalled RNA polymerase II (Pol II) sites by ERCC6/CSB (PubMed:32355176). UV-induced translocation to the nuclear matrix is dependent on ERCC6/CSB (PubMed:26620705). {ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:32355176}.
Interaction partners:
- Cullin-4A
- DNA excision repair protein ERCC-6
- DNA damage-binding protein 1
- UV-stimulated scaffold protein A
- E3 ubiquitin-protein ligase RBX1
- DNA excision repair protein ERCC-5
- Cullin-4B
- DNA excision repair protein ERCC-1
- DNA repair endonuclease XPF
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG