wanglab/gogpt-training-data huggingface dataset:
Protein: Dynein light chain Tctex-type protein 2 (T-complex testis-specific protein 3) (T-complex-associated testis-expressed protein 3) (Tcte-3) (Tctex1 domain-containing protein 3) (Q8IZS6)
Organism: Homo sapiens (Human)
Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P11985}. Cytoplasmic granule {ECO:0000250|UniProtKB:P11985}. Membrane {ECO:0000250|UniProtKB:P11985}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11985}. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis. {ECO:0000250|UniProtKB:P11985}.
Interaction partners:
- Dynein light chain Tctex-type 1
- T-complex protein 10A homolog.
- PHD finger protein 10
- Cytoplasmic dynein 1 intermediate chain 2
- Dynein regulatory complex subunit 5
- Dynein light chain 1, cytoplasmic
- Dynein light chain Tctex-type 3
- Dynein light chain roadblock-type 1
- Cytoplasmic dynein 2 intermediate chain 2
- Dynein light chain roadblock-type 2
Sequence:
MEKRGRGVKSSPIQTPNQTPQQAPVTPRKERRPSMFEKEAYTQILRERLRESIHNVQYVEPPFDDSIADIGKEWKSALAKLKFANSYRMEPLKKFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHEAESYVALVLVFALYYE
Protein: Cyclin-dependent kinases regulatory subunit (Q8IEX0)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSGRDYFSITDPVQREQARMMISKLQSKILYSDKYYDDEYEYRHVILPKDFSRLVPRGRLMEESEWRQLGVQQSVGWRHYMLHAPEPHVLLFKRPKTQ
Protein: Large ribosomal subunit protein mL46 (39S ribosomal protein L46, mitochondrial) (L46mt) (MRP-L46) (Q3SZ22)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9H2W6}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL34m
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein uS11m
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS7m
Sequence:
MAAPTRRTVLGLARCWRRFESPWSLGSRSLTLAAAPSNSASPWRLLGALCLQRPPLVSKQLTPMQEEMAALLQQMEIERSLYSDHELRALDEAEQLEKKKSDLYEEKDEKNILLVQDLEDMWEQKFLQFKPGARITDADVKNDRSSLHRKLDRNLILLVKDKLGDQDVWMLPQAEWQPGETLRQTAERTLATLSENNLEAKFLGNAPCGHYKFKFPQAVRAEGSLGAKIFFFKALLLTGDFSPAVEKGRHVWASKEELGDYLKPKYLAQVRRFLLDL
Protein: LD41575p (LP21705p) (Q8SWS5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFGASDQGKLIASALVRFAYPMRHDLSFAYAHREPYYSTLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDTKSENVMLELVRKCDAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVTGNLQLSTLSSFFPFGNPIAGDAPLQLYDILSSSSELLMETSSFLDKSSIV
Protein: Embryo sac development arrest 12 (Q8GYK3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MARNHQFRVDLEEMGFRSRSHLFLNEFETSAGRFNLLSRNHRDHLYVSDVVDTLSEQFSSMSLLHPKPRLVPTLPSSLQSSLRPNGVKAYQRLYRERLKLEPFYELHLSRIRKESQQDRAKVLQRQEARLQKRGLVHRNGNVLKESVGTGVFHPLQRPTFKTFDPVKKHNQRNRNQSEKEFMTKEKRGVMTSTTQEQQQKEECHYHLPSDMDFSKDWTF
Protein: Ras-related protein Rab-7a (C0HBN0)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- RILP-like protein 2
- RILP-like protein 2
- TBC1 domain family member 15
- TBC1 domain family member 15-like
- TBC1 domain family member 15
- Rab proteins geranylgeranyltransferase component A 2-like isoform X1
- FYVE and coiled-coil domain-containing protein 1
- FYVE and coiled-coil domain-containing protein 1
- Cytoplasmic dynein 1 heavy chain 1
- Dynein light intermediate chain
Sequence:
MASRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPNTFKTLDSWRDEFLIQASPRDPDNFPFVVLGNKIDLENRQVTTKRAQAWCASKSSIPYFETSAKEAINVDQAFQTIARNALKQESEVETYDFPDQIKLRDDRPAASSDSCSC
Protein: Dysbindin domain-containing protein 2 (Casein kinase-1 binding protein) (CK1BP) (HSMNP1) (Q9BQY9)
Organism: Homo sapiens (Human)
Function: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).
Interaction partners:
Sequence:
MGAGNFLTALEVPVAALAGAASDRRASCERVSPPPPLPHFRLPPLPRSRLPGPVSRPEPGAPLLGCWLQWGAPSPGPLCLLFRLCSCTCFAPLPAGADMDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS
Protein: Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H) (O14894)
Organism: Homo sapiens (Human)
Function: Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to cell membrane increases during conditions of arginine depletion and translocation to lysosome membrane seen upon arginine repletion. {ECO:0000269|PubMed:30956113}.
Interaction partners:
- Tetraspanin-1
- Tetraspanin-7
- Cadherin-related family member 1
- Epidermal growth factor receptor
Sequence:
MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (A4FUX2)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTLNLPRRRLLMLLIALGLTQGDPLKPSRGPLVTCTCENPHCKGPTCQGSWCTVVLVWEDGHLREYRGCGNMHPEVCRARPTEFVNHYCCYSPLCNHNVSLTLEATQTAPEQPQGDGQLPLILGPVLAFLVLVALGALGLWHVRRRKEKQRGANSELGESSLILKPSEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALKLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLEEQIRTDCFESYKWTDIWAFGLVLWEITRRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSNGLQKPKVIP
Protein: Phosphoglucomutase (PGM) (EC 5.4.2.2) (Glucose phosphomutase) (O74374)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6-phosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Probable phosphoribomutase
- Hexokinase-2
- Hexokinase-1
- Probable transketolase
- Transaldolase
- Ribose-5-phosphate isomerase
- Glucose-6-phosphate 1-dehydrogenase
Sequence:
MIETIPTKPYEGQRPGTSGLRKKVTVFEQPNYVENFVQATMDVVEPSAKGAHLVVGGDGRYFNFHAIQVIAAIAAGNGVEKIIVGTNGYLSTPAASHIIRKYKLTGGIILTASHNAGGPKNDFGIKYNLGNGGPAPESVTEKIYSITKTISEYKMVKIPPLDLTTTGVRRYGPLTVEVIDPVKDYVQLMKEIFDFDLIRSFLSKNPDFTFVFDALHGITGPYGEALFCKELGMPSSVCQNCKPLPDFGGGHPDPNLTYAKSLVARVDRDNIVMGAASDGDGDRNMIYGANAFVTPSDSVAIIAHHAELIPYFRDGGVHGFARSMPTSGAIDRVGKYKGKNVYEVPTGWKFFCNLFDAKRLSICGEESFGTGSDHIREKDGVWGILCWLNILAGLNAQNPKIKTLIDVKKDFYNIYGRTFYSRYDYEELENEAAGKVMDRMRAIADDKSKVGEAVLPGFVVSEAGDFEYHDPIDGSESKHQGLYIKFENGSRIVTRLSGTGSSGATLRLYMEKHESDSSKFDLDAQVALKPVVHAALEILALEELTGRKEPTVIT
Protein: Molybdopterin synthase sulfur carrier subunit (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Sulfur carrier protein MOCS2A) (Q9S7A3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03051}.
Interaction partners:
- Molybdopterin synthase catalytic subunit
- GTP 3',8-cyclase, mitochondrial
- Cyclic pyranopterin monophosphate synthase, mitochondrial
- Adenylyltransferase and sulfurtransferase MOCS3
- Molybdopterin biosynthesis protein CNX1
- Ubiquitin-related modifier 1 homolog 1
- Nucleolar complex-associated protein 3
- ABC transporter B family member 25, mitochondrial
- Ubiquitin-related modifier 1 homolog 2
- At5g46840 family protein)
Sequence:
MDKEVTKIESDDTSSVEIKVLLFARARELTGVPDLTLKMPSGSTTQKCLDELVLKFPSLEEVRSCVVLALNEEYTTDSAIVQHRDELAIIPPISGG
Protein: glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39) (F4K6W1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Actin-related protein 4
Sequence:
MSSHDTYQKLILFCLSIFFLQNILKNVEGLACNWGTQASHPLPPNIVVKLLRDNGFNKVKLFEADPGALRALGKSGIQVMVGIPNDLLATMASTVTNAELWVQQNVSQYISRYGTDIRYVAVGNEPFLKTYNNRFVRSTYPALQNVQAALVKAGLGRQVKVTVPLNADVYESSDGLPSSGDFRSDIKTLMISIVRFLADSVSPITFNIYPFLSLNADPNFPREYAFFPNGGGGGGAKPVVDGSISYTNVFDANFDTLVSALEKNGFDANKIEIIVGEVGWPTDGDQNANPAMAQRFNQGLLNRILQGQGTPRRRMAPEVYIFSLVDEDAKSIDPGKFERHWGIFSYDGAVKYPLSLGNGRPLVPTKGVRYQAREWCVLSTQAAGNGAATWQASATYACQNADCTSLGPGSSCAALDPTANASYAFNMYFQKMDHRRGSCDFNNLGVVTKIDPSSGSCRFPIEIDTSRQQMSNPPPRNSGASEAKYRLGAAVVMVICLVFSN
Protein: Hephaestus, isoform B (Hephaestus, isoform E) (Hephaestus, isoform F) (Hephaestus, isoform I) (Hephaestus, isoform J) (Hephaestus, isoform K) (Hephaestus, isoform N) (Hephaestus, isoform P) (Hephaestus, isoform V) (LD11808p) (Q8WR53)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMSCPIPMPMPISSLHKSEFEPVNIGVKRGSDELLSQAAVMAPASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSGDKIVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKSNI
Protein: Sodium/hydrogen exchanger (Q8WPH4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKVFLHLSL
Protein: Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) (Q6R6I7)
Organism: Mus musculus (Mouse)
Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Relaxin-3
- Insulin-like 3
- Prorelaxin 1
- Relaxin-3 receptor 1
- Relaxin-3 receptor 2
- Insulin-like peptide INSL5
- Guanine nucleotide-binding protein G
- Relaxin receptor 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MTSGPFFFCIFIIGKYFTLGSAQDVSCPLGSFPCGNMSRCLPQLLHCNGVDDCGNRADEDHCGDNNGWSLQLDKYFANYYKLASTNSFEAETSECLVGSVPMHCLCRDLELDCDEANLRAVPSVSSNVTVMSLQRNFIRTLPPNGFRKYHELQKLCLQNNRIHSVSVSAFRGLRSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTFYGLNSLILLVLMNNALTRLPDKPLCQHMPRLHWLDFEGNRIHNLRNLTFISCNNLTVLVMRKNKINYLNEHAFTHLQKLDELDLGSNKIENLPPNIFKDLKELSQLNISYNPIQKIEVNQFDCLAKLKSLSLEGIEISNIQQRMFRPLINLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAITCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGVYLFVIGAFDLKFRGEYNKHAQPWMESVHCQFMGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCLRPRKCRTITVLIFIWIIGFIVAFAPLGNKEFFKNYYGTNGVCFPLHSEDTGSTGAQIYSVVIFLGINLVAFIIIVFSYGSMFYSVHQSSVTVTEIQKQVKKEVVLAKRFFFIVFTDALCWIPIFILKFLSLLQVEIPDSITSWVVIFILPINSALNPIIYTLTTRPFKEMIHQLWHNYRQRRSVDRKETQKAYAPSFIWVEMWPLQEMSSGFMKPGAFTDPCDLSLVSQSSRLNSYS
Protein: Insulin-like growth factor 2 receptor (A0A8I6GLL6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004608}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
Sequence:
LLCQFRSKLQSVPEAGLLYTLLLIFFFPESITVTNLFAFFLSSYTWEAVDSKNNAVYKINPCGHVDNPRCGPTSAVCMCDLKSENCRSVGDSLLRSSAKSLLEFNTTTGCQPSEHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDIFKADKEVPCYVFDDKLQKHDLNPLIKLNGGYLVDDSDADASLFINVCRDIDSLRDPSTQLRVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPAVTVTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLESETCSLSSEQHDIAIDLSPLAQHEEGSPYVADGGEYRFFMNVCGDTKVSLCNKEAAVCQEKKVDSTQVKIAGRHQNQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGQDGRGEPVFTGEVDCTYFFTWDTKYACVKEKEDLLCGAIDGKKRYDLSVLARHSESEQNWEAVDGSQAESEKRNFFINVCHRVLQAGKAKNCPEGAAVCAVDKSGSKNLGKFVSSPTKEKGHIQLSYSDGDDCGNDKKITTNITFVCKPGDLESAPVLRAAGPDGCSYEFEWHTAAACVLSQTEGENCTVLDAQAGFSFDLSLLTKKNGAYKVETDKYDFYINVCGPVSVNLCQSNSGACQVAKSGKSWNLGLSNTKLTYYDGMIQLSYRNGTLYNNEKHTPRSTLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKFEGGRGGNWYAMENSREHFTRRKYYLNVCRPLNPVPGCDRYASACQMKYENNEGSLAETVAISNLGVAKTGPVVEESGSLLLEYVNGSACTTSDGRLTTYSTRIHLVCGRGTMNSHPIFTFNWECVVSFLWNTEAACPIQTITDSDQACSIRDPNSGFVFNLSPLNYSQGHMVLGIGKTFVFNICGTMPACGTVAGKPALGCEAETKIKDIKDLKPERPVGMEKSLQLSAEGFLTLTYKGSSPSDRGTAFIIRFICNGDIYPGTPKFLHQDIDSARGIRNTFFEFETALACIPSVVDCQVTDPAGNEYDLSALSMVRKPWTAVDTSVHGKKRRFYLSVCTPLPYIPGCDGIAMGSCMVSEDKSQNLGVVQISPQATGNGSLSILYVNGDRCGNQRYSTRIVFECAQTSGSPMFQLLNNCEYVFVWRTVEACPVVREEGDNCQVKDPRHGNLYDLKPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKGPQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHKVYQRSTTIYFYCDRTTQKPVFLKETLDCSYLFEWRTQYACPPFNVTECSIQDEAGNSIDLSSLSRYSDNWEAVTRTGATEHYLINVCKSLSPQAGTDPCPPEAAVCLLDGSKPVNLGRVRDGPQWTAGVTVLKYVDGDLCPDKIRKRSTIIRFTCSDSQVNSRPLFISAVQDCEYTFSWPTPAACPVKSNIHDDCQVTNPSTGHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQTRISVGQASKRLSYKDQVLQLVYENGSPCPSKSGLRYKSVISFVCRPEAGPTNRPMLISLDKQSCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEAYDESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIFNPVANEVYLNFESSTPCLADKYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDAHTYSIGVCTTAADLDQEGCKDGGVCLLSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETEDGEPCVFPFIYKGETYDECVLEGRAKLWCSKTANYDRDHEWGFCRPSNSHRMSAIIFTCDENEDIGRPEVFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNSYFINLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVLVTYSKGHSCGGNKTASSVIELTCAKTVGRPAFKRFDIDSCTYYFYWYSRAACAVRPQEVNMVNGTLTNPVTGKSFSLGEIYFKLFSASGDMRSNGDNYLYEIQLSSISSSSNPACSGANICQVKPNDQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSTCGKDKTKSVSSTIFFHCDPLLKDGVPEFSHETADCQYLFSWYTSAVCPLGVDFDDENAVPEYKGLSERSQAVGAVLSLLLVALTGCLLALLLHKKERRETVINKLTNCCRRSSGVSYKYSKVSKEEETDENETEWLMEEIQVPAARLGKDGQENGHITTKTVKAEALTSLHGDDQDSEDEVLTIPEVKVHTGRGAEVESSQPLRNPQRKVLKEREGERMGLVRGEKARRGKFRPGQRKPTTPAKLVSFHDDSDEDLLHI
Protein: Stimulated by retinoic acid gene 6 protein-like (STRA6-like protein) (Retinol-binding protein 4 receptor 2) (RBP4 receptor 2) (Q9DBN1)
Organism: Mus musculus (Mouse)
Function: Acts as a high-affinity cell-surface receptor for retinol-binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23105095}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Coiled-coil domain containing 180
Sequence:
MLAASTRTRQINITCDNPVDREVFLHYSLIPSLCIILVLSFLQRREHRRQRDDTSYLLGNHFGIIVPLDFVGTFSNRWSYGAAFGATANKVMFLFSEGYQPLTVPQWAQAFVLFIGGMEVGLSYFPFFACLSSEFQLVSSILGFSYSLTWFVVTVLQISQCPHGQFLGRFETLVFYWPSLLCLGFLLGRFLHMFLKALPVHLGLEPQTEEKSMLEAHQAKHVKQLLSKPRPQEGEKSWFQTRVYEWDPCFQFPSRMVGTLLLAFICLYLFIVIEFCVFLHVRDKLDMFEDKLESYLTHMNETGTLTPIILQVKELISVTKGVWVVTILPAALTCVTYLFHILACYRKHMKRLWAGDKHFLPQKFHSPSSAASVVAIARYSGWQIAYILWGYLIIHVVQSLCGVMLMYGLVLPIIHHRGLEMLQGFGLGVLTLSIVVGLIILQVWIAGTFFLQPKLGTSDKQKPLALNNRRAFHNFNYFLFFYNVLLGLGACLSRLLISCLLGTWLIARIDRTIMQSGYEGADMGFGAWIGMLFVDHYHTNPVLVSFCHILITSHKDRKLQKTVKYWCLNQSAGPRFSARARTRWFLLQTLINNPRLVMLRKSKSGHSSGEFTQILLTCSDC
Protein: thymidine kinase (EC 2.7.1.21) (Q38CF2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Cytidine deaminase, putative
- dTMP kinase
- dTMP kinase
- Deoxyuridine triphosphatase, putative
- Peptide chain release factor 1, putative
- Prokaryotic-type class I peptide chain release factors domain-containing protein
- Bifunctional helicase and thymine dioxygenase JBP2
- Thymine dioxygenase JBP1
- Eukaryotic translation initiation factor 5A
Sequence:
MHDGDGNIELIIGPMFAGKTTELMRRVQRHKHAQRSCYIINYSRNSYQNQRLSTHDQLSLTANVSIAKLSEVCDEWRDYDVIAVDNGQFFPDVVGFCARAANEGKTVIVSALDVDCRETPFDEVCRLVPRAESVLKLSAVCMECHEHDAFLTYRTIESNERELYGGADMYLAVCRWCYKQLTMSHVDAQKTSASTAAVVPNGAHGRIELIIGPMFAGKTTELMRRVQRHKHAQRSCYIIKYTGDTRYSEGAITSHDQRALTANVSVSNLHDVGDEWRKYDVIAVDEGQFFPGVAAFCSKAADSGKVVIVSALDADYLQEPFEEICLLVSRADSVVKLSAVCMECHNRKASFTYRTVKSDERKLVGGSDMYMSVCRSCYETKRNMVQTEKYIYSCVGINEGSYSECSPGPSERSSAGTSGVQTSVKVDEQNCTEPNTEAKKMPLKRKRNQMAVDTT
Protein: Large ribosomal subunit protein P2A (60S acidic ribosomal protein P2-A) (CaRP2A) (Q9HFQ5)
Organism: Candida albicans (Yeast)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
Sequence:
MKYLAAYLLLVNAGNATPSAADVKAVLSAADIEVEEEKVEKLISESDGKNVEELIAEGNEKLSSVPSGAPAAAAGGASAAAGGEATEEAAEEEAAEESDDDMSFGLFD
Protein: Gap junction delta-4 protein (Connexin-39) (Cx39) (Q8BSD4)
Organism: Mus musculus (Mouse)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
Interaction partners:
Sequence:
MEKLNLLGFLIITLNCNVTIMGMIWLIVEVLLRMLVVVLAGSPIYEDEQERFICNTLQPGCANVCYDLFSPVSPLRFWLVQSLALLLPSVVFGTYTLHRGAKLAAVGGACRPQVPDLSTAYLVHLLLRMLLEAGLAFLHYFLFGFSVPARVSCSHVPCSGAVDCYVSRPTEKSLLILFFWAVSALSFLLSLADLLWILPRRKTLRTTQWVNGEARPVCEVPAPPPCLLQNPQGYLSQGQVDQEDRQEEQVVPEFPCMWTAGQSDNSNVGQACVSGLLEHSDQDASEATSSAGDRLTVAHTAHELRFHRETSLDLGGKNTQADELSLATQSHLARHSSASKPQAPCRLTTSGSAPHLRTKKSEWV
Protein: PP2A regulatory subunit TAP46 (2A phosphatase-associated protein of 46 kDa) (Q8LDQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the positive regulation of the TOR signaling pathway. Acts as a negative regulator of PP2A catalytic activity. Plays a positive role in the ABA-regulated inhibition of germination, probably throught its interaction with ABI5.
Interaction partners:
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
- Phytochrome-associated serine/threonine-protein phosphatase 1
- Regulatory-associated protein of TOR 1
- Target of rapamycin complex subunit LST8-1
- Regulatory-associated protein of TOR 2
- Serine/threonine-protein kinase TOR
Sequence:
MGGLAMEEMPLSVLFEQARKIHLAASESGVDQDVVKKGCEMFQKCEDMIGKLALFSSNETKEDISTNNLKYLLVPYYLAELTEKIIQEDRIQIVKASYAKLKEFFSFCEAMELVPDEELEASSRGGSGAPADRRALKIARFKRQKAAEAKLLEIKERKERRGRSTKASALSTPVESGEDDIPDDDSEEEREAWLSSINLAICKAIDLLEMLKREEEMLSAIKERQLKDGEGGFSRDALDDRTKKAETWHRDAAARIQYSKPAQPITCATFAQDVLEGRASVSQGHEHKNQPLIFGPASIVGGPLSTERERMIAQVFQPSHRMPTMCIEDAGLTEMNIMNDWQEQTKKAIEEATTSWYNDKPLRRKEEDEEDDDEDEEAVMKARAFDDWKDDNPRGAGNKKLTPCG
Protein: Prolycopene isomerase, chloroplastic (CrtISO) (EC 5.2.1.13) (Carotenoid and chloroplast regulation protein 2) (Carotenoid isomerase) (Q9M9Y8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carotene cis-trans-isomerase that converts 7,9,9'-tri-cis-neurosporene to 9'-cis-neurosporene and 7,9,9',7'-tetra-cis-lycopene (also known as prolycopene) into all-trans-lycopene. Isomerization requires redox-active components, suggesting that isomerization is achieved by a reversible redox reaction acting at specific double bonds. Isomerizes adjacent cis-double bonds at C7 and C9 pairwise into the trans-configuration, but is incapable of isomerizing single cis-double bonds at C9 and C9'. Carotenoid biosynthesis is partly required to form the prolamellar bodies of etioplasts.
Subcellular location: Plastid, chloroplast membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- Lycopene beta cyclase, chloroplastic
- Phytoene synthase 1, chloroplastic
- Lycopene epsilon cyclase, chloroplastic
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- 15-cis-zeta-carotene isomerase, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- Violaxanthin de-epoxidase, chloroplastic
Sequence:
MDLCFQNPVKCGDRLFSALNTSTYYKLGTSNLGFNGPVLENRKKKKKLPRMVTVKSVSSSVVASTVQGTKRDGGESLYDAIVIGSGIGGLVAATQLAVKEARVLVLEKYLIPGGSSGFYERDGYTFDVGSSVMFGFSDKGNLNLITQALKAVGRKMEVIPDPTTVHFHLPNNLSVRIHREYDDFIAELTSKFPHEKEGILGFYGDCWKIFNSLNSLELKSLEEPIYLFGQFFQKPLECLTLAYYLPQNAGAIARKYIKDPQLLSFIDAECFIVSTVNALQTPMINASMVLCDRHYGGINYPVGGVGGIAKSLAEGLVDQGSEIQYKANVKSIILDHGKAVGVRLADGREFFAKTIISNATRWDTFGKLLKGEKLPKEEENFQKVYVKAPSFLSIHMGVKAEVLPPDTDCHHFVLEDDWKNLEEPYGSIFLSIPTILDSSLAPDGRHILHIFTTSSIEDWEGLPPKEYEAKKEDVAARIIQRLEKKLFPGLSSSITFKEVGTPRTHRRFLARDKGTYGPMPRGTPKGLLGMPFNTTAIDGLYCVGDSCFPGQGVIAVAFSGVMCAHRVAADIGLEKKSRVLDVGLLGLLGWLRTLA