wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-1,2-mannosyltransferase MNN22 (EC 2.4.1.-) (Q5A687)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGSIFKDGRRILVRPKSLIICLCLISIIFTQLIRYQYQLIADEVQPTINEDHSSSQSLKNTKLNSTRSSSPISPPKSLNKLTSQEFWEHIFNIFEINKFDDGLKPLIKYTPKEQQLTTKIKTRDWLLSKANIFHKDIIRQYHESVLRNLPSKLPKSVYTPNTYGIVTIGGNFYSWMAYIQLLQLRKLGSNLPVEILIPSIEDYYKEAHFCDHVLPQYNAKCILVPEKLGFNVAKHWKFSSYQFKALALCLSSFQHVLILDSDNVVLSKPEKVFDSPVYRDNGMVLWPDYWERTISPEWYDIIGKPVVGNKQVRTGRFPVNIHNMLTSELEINETRFHDLEGALPDLSTESGQVMFNKKTHGKVMLMTLYYNIFGPEIYYKLFSLGALGEGDKDTFAAAALACGEKYYQVASSIRTLGYFDTTPGGGFHGMAMAQKNPQLDYQLFQKTNQNFKDLHLDWDNEAKDQFSANNKIPIFTMHCNIKKINPAAYMKDEKIANMDEKRMNVRFYSNLKFKLNDDDIYSPDNEKEKNKSEKTDNDPNEIDFELSRWQIVSEILCDQKITFQFLKDENMDEVCQFVKNTIAWLGKKT
Protein: Subtilisin-like protease (F4IFV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Subtilisin-like protease SBT1.2
- BTB/POZ domain-containing protein At1g01640
- Putative BTB/POZ domain-containing protein At4g04090
- Putative BTB/POZ domain-containing protein At2g40450
- BTB/POZ domain-containing protein At1g21780
- Putative BTB/POZ domain-containing protein At2g05330
- BTB/POZ domain-containing protein At5g48510
- BTB/POZ domain-containing protein At3g56230
- BTB/POZ domain-containing protein At4g08455
- BTB/POZ and MATH domain-containing protein 4
Sequence:
MVKQCSPAHNIFERVSKCYVEKQQPHDVSIPNIRLTVSATGLAFGSVHQANANQNQIACFYFSCNFSSKSNHHQSQAIVREEIQKNLRPVRIVGHQSMASSWRRSIGNVRSFIGNSMGGLRGGQSAASWVVAGTIAYFLWIKPEQDLKKEQEARAALAMADTNQYVEKRKPIADPQVTGLIYGNKNGTDKSED
Protein: FACT complex subunit SPT16 (Facilitates chromatin transcription complex subunit SPT16) (O82491)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:15546350}. Chromosome {ECO:0000269|PubMed:15546350}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Interaction partners:
- FACT complex subunit SSRP1
- Protein CDC73 homolog
- Protein CTR9 homolog
- Protein LEO1 homolog
- Transcription elongation factor SPT6 homolog
- Protein PAF1 homolog
- Protein RTF1 homolog
- Transcription elongation factor SPT6-like
- Transcription elongation factor SPT4 homolog 1
- DNA-directed RNA polymerases IV and V subunit 3B
Sequence:
MADSRNGNARAPPSGVPPKAGNTYSIDVKNFISRARALYEHWKKHSADLWGSADALAIATPPASDDLRYLKSSALNIWLLGYEFPDTIMVFTKKQIHFLCSRNKASLLEVVKKPAHDELKLDVIMHVKPKGDDGTGLMDAIFRAIRDLSRGDGNDSQVVGHIAREAPEGKLLETWTERLKNANFQFVDITGGLSDLFAVKDDTEVMSVKKAAYLAYSVMKNVVVPNLESAIDEEKDVTHSALMDLTEKAILEPTKASVKLKPENVDICYPPIFQSGGKFDLKPSAASNDELLTYDPASIIICAVGARYNSYCSNVARTYLIDATSLQSKAYEVLLKAHEAAIDALRSGRKINTVYQAALSVVEKNAPEFVDKLTKSAGTGIGLEFRESGLNINAKNDKVLRPKMAFNVSLGFQNLECESESRSKNKKFSLLLADTVLVTDQKPELLTKCSKSVKDVAYSFKEDEEEEKPRKKARTSGSENYITKTALRSDDHVVSKEELRKQHQAELARQKNEETARRLAGDSSGAGDSRSTAKTSADVVAYKNVNDMPHKELMIQVDTRNEAVLLPIYGSLVPFHVATIRTVSGNQDTNRNCYIRIIFNVPGTPFNPHDSNSLKNQGAIYLKEVSFRTKDSRHSSEVTQQIKTLRRQVMARESERAERATLVTQEKLQLAGNKFKPLRLSELWIRPPFSGRKKIPGTLEAHANGFRYSTTRPDERVDVLFANIKHAFFQPAEKEMITLLHFHLHNHIMVGTKKTKDVQFYVEVMDVVQSLGGGRRSAYDPDEIDEEQRERDRKNKINMDFNHFANRVNDMWQLPQFASLDLEFDQPLRELGFHGVPHKTSAFIIPTSSCLVELIEYPFLVVSLSEIEIVNLERVGFGQKNFDMAIIFKDFKKDVLRVDSVPTSSLEGIKEWLDTTDIKYYESKLNLNWRQILKTITDDPQSFIDDGGWEFLNLDGSDSESGGSEESDKGYEPSDVEVESESEDEASESESLVESDDDEEEDSEQESEEEKGKTWDELEREATNADREHGVESDSEEERKRRKMKAFGKSRPGTSGGGGSSSMKNMPPSKRKHR
Protein: Transport and Golgi organization protein 1 (Q9VMA7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier. At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16452979, ECO:0000269|PubMed:23369713}; Single-pass type I membrane protein {ECO:0000269|PubMed:16452979}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23369713}.
Interaction partners:
- FI09914p
- Protein transport protein SEC23
- Protein transport protein Sec31A
- small monomeric GTPase
- Protein SEC13 homolog
- Secretory 16, isoform I
- Ergic53, isoform A
- Golgi matrix protein 130 kD
- N-acetylgalactosaminyltransferase 4
- Transmembrane protein 131 homolog
Sequence:
MRLTNEKATMQPQLSDLALVLGLLICCLPTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLSKSAGSNMQLWGVDINGRRGYANKDFIMEKKILVRDKDLLYEVPVVGPGSPVQSVETPVQSVETTVQPVLNASESTDDLATTTTSPLEIAVDSIVVEHDKLQDQQVPDPTAASKAQVQVIEGTELPLEAIAATTEGSIVPETAADPQEATNLDSTVVDTKEPQALNSEAIKLQEEPKAQQPATEAEKPPPLPQAINAELEDADDFDYGDDETDDDSQQGSQDNESIVEIANDNKSINESIELKPLSVAQLKKTDKVEDSKDETKEKHAEMEVSKQEDSSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSDPLPVEEVTETVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKAPSESVISSTTPAPVVEEAPQKADPVGLPPLFEKKNFENPNNYYKQLQEEQEKQRLVAEAEEQKRLQEEADQQKRLQEEAALNKRLLEEAEQQKRLQEEAEQQKRLQEEAELNKRLLEEAEKQKRLHEESEQLQRSSEEAEPQLSVQEANMQQLNDSVDSQSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTASHTTPTPDAESPYAAVQEETTEASQTDNHREGVGYVEPVALPATASPVSEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEVPPSQRKAEDFAPADVDGYCARFQAKDEHCHRSISLDNFVEVMADKLVDHSQLLLCVVIAAISSLFFMFAYYCFCNSSQEGALLSKLNHLERSLLASHKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAAEAGLELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRENSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGAELKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSRGDRDRERYSDYSDYDDYDDDEEDDRGMDRRRRHSGSWGRRHRGSYSHSPRTYRSLSPSDSRYNYNDTETDFSPPPSPPPVPSGRSATSRPYSEV
Protein: At3g15110 (Transmembrane protein) (Q2HIU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLVLQSHQCLFSLPYRLRPTRLISPIHSLSSFTRIRPGIIRLSAVKEIADVAEVEEDGPIELPTSSTSPFSSTNSIFATSDDPTPLQLATSVLLTGAITVFLIRSVRRRAKRAKELTFRSTGAKKSLKEEAMDNLKALSSTPIEGGNSTPSAAQAFLGAIAAGVIALILYKFTVTVESGLNRQTISDNFSVRQITVTVRTIINGICYLATFVFGLNAFGLLLYSGQLAFNEDSAEENMKATTQPGDSSSGDNSEVNKSNEDQSSGD
Protein: SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) (Q91Z69)
Organism: Mus musculus (Mouse)
Function: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity).
Interaction partners:
- Roundabout homolog 1
- Cell division control protein 42 homolog
- Roundabout homolog 2
- SLIT-ROBO Rho GTPase-activating protein 2
- SLIT-ROBO Rho GTPase-activating protein 3
- Transforming protein RhoA
Sequence:
MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHSESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTSRGRRNSHARHQDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLSDEQSNHDINSVAGVLKLYFRGLENPLFPKERFTDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSNSSIDLGSPNLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRGSEPQIRRSTSSSSETMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTMGPAAPSQGPTDKSCTM
Protein: UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.87) (Polymyxin resistance protein PmrH) (UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase) (UDP-Ara4O aminotransferase) (UDP-4-amino-4-deoxy-L-arabinose aminotransferase) (P77690)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Interaction partners:
- Bifunctional polymyxin resistance protein ArnA
- Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
- Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
- Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
- Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
- Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF
- UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
- Phosphoethanolamine transferase EptA
- UDP-glucose 6-dehydrogenase
- Sensor protein BasS
Sequence:
MAEGKAMSEFLPFSRPAMGVEELAAVKEVLESGWITTGPKNQALEQAFCQLTGNQHAIAVSSATAGMHITLMALKIGKGDEVITPSLTWVSTLNMISLLGATPVMVDVDRDTLMVTPEAIESAITPRTKAIIPVHYAGAPADIDAIRAIGERYGIAVIEDAAHAVGTYYKGRHIGAKGTAIFSFHAIKNITCAEGGLIVTDNENLARQLRMLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLVKLEHLNTRRREIAQQYQQALAALPFQPLSLPAWPHVHAWHLFIIRVDEQRCGISRDALMEALKERGIGTGLHFRAAHTQKYYRERFPTLSLPNTEWNSERICSLPLFPDMTTADADHVITALQQLAGQ
Protein: Furin-like protease 1, isoform 1-CRR (Furin-1) (EC 3.4.21.75) (Kex2-like endoprotease 1) (dKLIP-1) (P30430)
Organism: Drosophila melanogaster (Fruit fly)
Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:8491178}; Multi-pass membrane protein {ECO:0000269|PubMed:8491178}.
Interaction partners:
Sequence:
MKNDVVRWSRQPTSNTTNSSSSSRSDSNSTHKHRSKSNKLNARQLGSNAARSCQQRSSVATTLEDEQQTIIECDIGNFNFDCNLFKTSFLTQHKQKRSGKSSSKSKSNRSRPLAKTKAVFLLALQFSAVVFLCNINVGFVAGSVATAASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPVHTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHSLLMSNSLDDKQDPLQAEDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKILNETFCYAYVVRSTGMASVVDISKMDDRDTQQYMTGTTVLLLVSVIFTLMGVAVAGGIVYHRRAMARSNELYSRVSLVPGDESDSDEDELFTAHFPARKSGVNIYRDEAPSEKIFEEDEISHLVP
Protein: Zcf31p (Q5ANI0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MFISHMSAPPSIPTITTPGTSSTNTRRVARRACLSCREKKIKCNGEPMTTITAADGTNRIIPEKTRTCSNCRFLGIPCVFVQSNRGGKRKKRSTEHQLSDSEATTAPATHPNQLGQHQQLPPIKKTKSTPSIHNLDSGVVIPSINQQQERHQDGYRNEELASTERVSSYILDGNNSTKLPSPVLTHTTFDSRRDEGQRFNNQLRRSSTTTAGFSLPPPQELLGRRSVSYSPGPSSIKSQLPHLTSSSTTTSSVQSPPPPPPPPQPPRGMGIQFHEASHQPGIFPPPPPPPPPPPPHPDHLHHQYYGYPPPPPPPPPPPLHHHHHYPPSHHPGFGFPPPPPGPPGPPGPPPVPPPPHYHQSAPPESPPKEFKHRHPKYFHKQNNKGHRHRHHPHLHHHHPPPPHHHHHHPRDFQQHNGQDDIKSKHTDENSQNSKPSSPRWLDNMSVSSSDSSRSVSSPQSQHNDKSQYSNHKSSTQMSSCTNSVTQTLDRLPKIVSTQQNNLTPTSKILSNSPFTESELAKYDLPKWEVLNKIFNYYYIYNQPSHQIFPGKAILLENLALNTDSSIIHAIIATTCLIISKYDSSINIVADELYWINKMHKFWDNLNDLGILCCYKLLVKCTSIRFNIKKMNDINIKLWEMINNNQYVDIFKQKKFDFQESRIIPTFGTKRQNYERELTLKIIWSFYINNIILLRFNQGRPYYKLSSIMNGFKFDYDRDQYSNNILLPMSDIDYLSLKSAGNRANWNQLYEKSHIPTDATSLILSSKSFENSLSKLSNKDITFSNLISKDEFHVDLRNKLKTKYYEIIHDEKLVVINTNYWFSNIILRLSELIQYNYILCDIMVFKMCKYDWKTDLGCNSDDRGDSKDTNTTQGEKCRDADGNSIQHKEDYKDSVSNPGLLQHPLISDEIQSVEGLTTKLKSLNNNDWKILIEMIKSTNEYVDLIKLIPSSEYTDYSIVVGPTTFDDNYNNENETTKRFRNLINNSSEWWNKQELKSSVQQSWAKLPIYILSFTSRVLSIIYSLAVLTKYIKFKKSFKSGDLIVEFLETNEVRTIEGCNISVLQQKQMSDVYEIFTEIHILSQLFVLCEYVKFKLSYSNEDLAALSIQRLNNLNQHLDEVLQQNFTKIKPE
Protein: Cannabidiolic acid synthase (CBDA synthase) (EC 1.21.3.8) (A6P6V9)
Organism: Cannabis sativa (Hemp) (Marijuana)
Function: Oxidoreductase involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity. Catalyzes the stereoselective oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA), producing cannabidiolate (CBDA), the major cannabioid in fiber-type Cannabis plants. Can also use cannabinerolic acid as substrate, but not cannabigerol or cannabinerol.
Subcellular location: Secreted {ECO:0000269|PubMed:8663284}. Secreted, extracellular space, apoplast {ECO:0000250}. Note=Probably sorted from the secretory cells into the storage cavity of glandular trichomes.
Interaction partners:
Sequence:
MKCSTFSFWFVCKIIFFFFSFNIQTSIANPRENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVCAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRH
Protein: Probable ribosylation factor GTPase-activating protein cnt6 (Q10165)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase-activating protein for the ADP ribosylation factor family.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cell tip {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Oxysterol-binding protein-like protein 1
- Acetyl-CoA carboxylase
Sequence:
MDGSDSLLKSVDVSKLDNGSTISFRAREDGFLESISSSSGKLVDMVLDSTSKECLPKFSFQNKLDFYFLFSDRVLQLQKERKVLVLIHCESLQSFDSFFAQKLKYADLISSDNVHEIFLPDSNAANIRYHWEWSPPSGKLLEYECKNYSCIAVYSTEDCTLERISKFSYYTVSRCGDSMDDTFFSESQRVTSPLTTSQTVQTQPPQSPEAKTELSLINTKTVIFPENYEDGPSFRSMLHELEQKSSLMKYYCKKIMKRIVQLSDAYDASQVAVMKLSETLSEASNSTSMNMDILLDSYLTKAMDIHATFIQKLNYDLINLLYEPFHNIYSSFIKPIDDRRLEFDEQSKSFYGSLSRYLSAKKDKKGGDSKFFQKEKTFALQRYDYYCFMQDLHDGSIINDINGIFLQYFHRQYDHIALFSNLMNSVLPNLQQLNLKLEKTKWSTTRRDKGREMHRSQVIQTSGRPKSMAPPSPSPISPSFPLHEIQSPMPNRRMAASADDISQTSNFTTEIKGKCISNGGSASPDKIFKEGLLLVFGATELGTDLAMVSKAAWHKHWIVVENGSLWEYANWKDSVKSNVSSISLKHASADKVRKQGRRFCFEVVTPKLKRLYQATSAEEMDSWIEAICEAAKISSFQLSRVATPLSASVRRPSKVFPLFSTSFETTPISRKLSGSGIKKAFSRKGSWNLQQFFRSDNSGTMHMEQLERYHASANIFIQMLRKTDVSNSVCADCGSVKDVTWCSINIPVVLCIECSGIHRSLGTHISKTRSLLLDSLSQQSKVLLCKIGNAAVNRVYEKGLSNPSLKPKPEHNAQVKLAFAQKKYVEHAFIDFAGVDADATLLEGLEQNKISKILLGLAAKPNFEENGVVFLKAVTRDTSKLHLLELLFMNGLLLPDSEQLSEHVSPDMQSYLSQKQFTKYLKE
Protein: L-threonine 3-dehydrogenase (TDH) (EC 1.1.1.103) (L-threonine dehydrogenase) (Q8U259)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of L-serine, D-threonine, butan-2,3-diol, butan-1,2-diol, and propan-1,2-diol and cannot oxidize other L-amino acids. Cannot utilize NADP(H) instead of NAD(H).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00627}.
Interaction partners:
- 8-amino-7-ketopelargonate synthase
- Threonine synthase
- Threonine synthase
- Threonine synthase
- Threonine synthase
- Threonine synthase
Sequence:
MSEKMVAIMKTKPEYGAELVEVDVPKPGPGEVLIKILATSICGTDLHIYEWNEWAQTRIRPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACKRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKNIPPEYATLQEPLGNAVDTVLAGPIAGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRNLAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLFPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNIDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
Protein: Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta-like protein (P0C2Y4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: This enzyme activity is not detectable in leaves.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305}.
Interaction partners:
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- 4-hydroxyphenylpyruvate dioxygenase
- 3-methyl-2-oxobutanoate dehydrogenase
- Malonyl CoA-acyl carrier protein transacylase containing protein, expressed
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
- Ribulose bisphosphate carboxylase large chain
- Acetyl-CoA carboxylase 1
- Acetyl-CoA carboxylase 2
- Phosphoglycerate kinase
- hydroxymethylglutaryl-CoA lyase
Sequence:
MALQSLRGSMRSVVGKRICPLIEYAIFPPLPRIIVYASRRARMQRGNYSLIKKPKKVSTLRQYQSTKSPMYQSLQRICGVREWLNKYCMWKEVDEKDFGFEIGAFD
Protein: Ionotropic receptor 8a (Q9W365)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ionotropic receptor 64a
- Ionotropic receptor 75a
- Ionotropic receptor 68a, isoform A
- Ionotropic receptor 21a
- Ionotropic receptor 40a
- Glycine--tRNA ligase
- Ionotropic receptor 75a
- Ionotropic receptor 31a, isoform C
- Odorant receptor coreceptor
- Ionotropic receptor 92a
Sequence:
MELPLLVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITLGDGKFKPRHGLYARRNLGASDSHSGYME
Protein: Uncharacterized protein (O53849)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL
Protein: Virulence factor mce family protein (O53540)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHGEGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVKLDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITEANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNLVPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFTTAYFDPNMAHMDEILNPPDFLIGELANLSGQAADPFKIPPGTASGQ
Protein: Testis-expressed protein 10 (Q9NXF1)
Organism: Homo sapiens (Human)
Function: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q3URQ0}. Cytoplasm {ECO:0000250|UniProtKB:Q3URQ0}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21326211}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250|UniProtKB:Q3URQ0}.
Interaction partners:
- Proline-, glutamic acid- and leucine-rich protein 1
- WD repeat-containing protein 18
- Ribosomal biogenesis protein LAS1L
- Sentrin-specific protease 3
- Polynucleotide 5'-hydroxyl-kinase NOL9
- Nucleolar GTP-binding protein 2
- GTP-binding protein 4
- WD repeat-containing protein 5
- E3 ubiquitin-protein ligase RING2
- Midasin
Sequence:
MTKKRKRQHDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQLKEDGTLPTNNRKLNIKDLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVFTDKDANVRLAAVQLLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQEDSLKVLDILLEQYPALITGRSSILLKNFVELISHQQLSKGLINRDRSQSWILSVNPNRRLTSQQWRLKVLVRLSKFLQALADGSSRLRESEGLQEQKENPHATSNSIFINWKEHANDQQHIQVYENGGSQPNVSSQFRLRYLVGGLSGVDEGLSSTENLKGFIEIIIPLLIECWVEAVPPQLATPVGNGIEREPLQVMQQVLNIISLLWKLSKQQDETHKLESWLRKNYLIDFKHHFMSRFPYVLKEITKHKRKEPNKSIKHCTVLSNNIDHLLLNLTLSDIMVSLANASTLQKDCSWIEMIRKFVTETLEDGSRLNSKQLNRLLGVSWRLMQIQPNREDTETLIKAVYTLYQQRGLILPVRTLLLKFFSKIYQTEELRSCRFRYRSKVLSRWLAGLPLQLAHLGSRNPELSTQLIDIIHTAAARANKELLKSLQATALRIYDPQEGAVVVLPADSQQRLVQLVYFLPSLPADLLSRLSRCCIMGRLSSSLAAMLIGILHMRSSFSGWKYSAKDWLMSDVDYFSFLFSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYLTDLDQFLHHWDVTEAVFHSLLVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVICKLLDHTCVVSETLLPFLASCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILALLPRVLRLMLQSLRVNRVGPEELPVVGQLLRLLLQHAPLRTHMLTNAILVQQIIKNITTLKSGSVQEQWLTDLHYCFNVYITGHPQGPSALATVY
Protein: Amyloid beta precursor protein binding family B member 3 (E7EX91)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGRGQYRGGAIVAVPCAPCDIYWCWPRPTHLWPHR
Protein: Opioid binding protein/cell adhesion molecule-like (Q6B0I4)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRSEPTVTWRHLSVKGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF
Protein: Virulence factor mce family protein (Q7D5E7)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDDF