wanglab/gogpt-training-data huggingface dataset:
Protein: Growth hormone (H6UQ65)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MAPGSWFSPLLIAVVTLGLPHETVATFPTMPLSNMFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMEVVRFSLVFIQSWLTPVQYLSKVFTNKLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
Protein: Vasoactive intestinal peptide (F4MJ04)
Organism: Columba livia (Rock dove)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
TDHAHGSLKSESDILQNTLPENEKFYFDLSRIIDSSQDSPVKRHSDAVFTDNYSRFRKQMAVKKYLNSVLTGKRSQEELNPAKLRDEAELLELSFSENYDSVDELLS
Protein: THO complex subunit 7 homolog (Ngg1-interacting factor 3-like protein 1-binding protein 1) (Q7TMY4)
Organism: Mus musculus (Mouse)
Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus speckle {ECO:0000250|UniProtKB:Q6I9Y2}. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000250|UniProtKB:Q6I9Y2}.
Interaction partners:
- THO complex subunit 3
- THO complex subunit 1
- THO complex subunit 5 homolog
- THO complex subunit 6 homolog
- THO complex subunit 2
- Spliceosome RNA helicase Ddx39b
- SAP domain-containing ribonucleoprotein
- THO complex subunit 2
- THO complex subunit 4
- ATP-dependent RNA helicase DDX39A
Sequence:
MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDDKLSEVDEAQESTMEADPKP
Protein: Mediator of RNA polymerase II transcription subunit 10b (F4HPA7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 7a
- Mediator of RNA polymerase II transcription subunit 22a
- Mediator of RNA polymerase II transcription subunit 7b
- Mediator of RNA polymerase II transcription subunit 22b
Sequence:
MDPTQNTSAGIGGSNGTIRYQTNDGTSTVTVADDSKENLSQVINSIEKTLGVLHQLHLTVTSFTPASQLHLLQRLNSLVMELDNMTKLSEKCNIQIPMEVLNLIDDGKNPDEFTKDVLNSCIARNQVTKGKTDAFKDLRKHILEELEQNFPDEVDMYREIRASSAAVTKRLAQSQSVLPNGDAKVKNEL
Protein: Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) (O75030)
Organism: Homo sapiens (Human)
Function: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Subcellular location: Nucleus {ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:28842328, ECO:0000269|PubMed:36608670}. Cytoplasm {ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:28842328, ECO:0000269|PubMed:36608670}. Lysosome membrane {ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:36608670}. Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR (PubMed:23401004, PubMed:36608670). Phosphorylation by MTOR promotes ubiquitination and degradation (PubMed:36608670). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:36608670). Phosphorylation by MARK3/cTAK1 promotes association with 14-3-3/YWHA adapters and retention in the cytosol (PubMed:16822840). {ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:36608670}.
Interaction partners:
- Transcription factor E3
- Tyrosinase
- Transcription factor EB
- Transcription factor PU.1
- L-dopachrome tautomerase
- Mitogen-activated protein kinase 3
- Transcription factor SOX-10
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Mitogen-activated protein kinase 1
- Transcription factor Jun
Sequence:
MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC
Protein: Dipeptide transport ATP-binding protein DppD (EC 7.4.2.9) (P0AAG0)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter DppABCDF involved in dipeptide transport. Responsible for energy coupling to the transport system (Probable).
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Dipeptide transport ATP-binding protein DppF
- Dipeptide transport system permease protein DppC
- Dipeptide transport system permease protein DppB
- Dipeptide-binding protein
- Nickel transport system permease protein NikC
- Probable D,D-dipeptide transport system permease protein DdpC
- Glutathione transport system permease protein GsiD
- Oligopeptide transport system permease protein OppC
- Putrescine export system permease protein SapC
- Aliphatic sulfonates import ATP-binding protein SsuB
Sequence:
MALLNVDKLSVHFGDESAPFRAVDRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLIDYPGRVMAEKLEFNGQDLQRISEKERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMEAIKVHQGGNKSTRRQRAIDLLNQVGIPDPASRLDVYPHQLSGGMSQRVMIAMAIACRPKLLIADEPTTALDVTIQAQIIELLLELQQKENMALVLITHDLALVAEAAHKIIVMYAGQVVETGDAHAIFHAPRHPYTQALLRALPEFAQDKERLASLPGVVPGKYDRPNGCLLNPRCPYATDRCRAEEPALNMLADGRQSKCHYPLDDAGRPTL
Protein: AT07585p (Q9VZ88)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAIDDMKDLLIVNVSDQEDAGMSDDLKETAMDCNMPDGESSLVITDGDSMSKIPDDAAMATSDPKKKKKKVKKLKRSQKAKDRLVRPLPKAVTSKDALMVLKELKGVIIDNMQIKQDHEGKNVANIVVNSKKYDAEGSSENSAGNAACEKALREILTTKMKALLAEPENSSGGDEDNILEKMTSYAVYKLAEKWNSDAIDVAALYNDVKNKKTSSSVGQLPKLWKNMHPCMVLMQMRPQTTFKFLGSSGENRKVFSMGVSVDNCEFKADGPTKKDARRKVAALVCNKLFGTDYPQA
Protein: Homeobox protein Hox-A11 (Homeobox protein Hox-1.9) (P31311)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Paired box protein Pax-2
- Homeobox protein Hox-A10
- Homeobox protein Meis1
- Forkhead box protein O1
Sequence:
MMDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKNAEKGPQAAAATSAAAVAAAATGAPATSSSDGGGGGGCQEAAAEEKERRRRPESSSSPESSSGHTEDKAGGSGGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL
Protein: Putative ras-related protein Rab-5B (Q54RX9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSNANNNGQATAKGGCCGGGGSQDNKANQNSGIVVSNTSTDNRNKFDKGFKLVLLGEMNTGKTCISSRLVRNEFGPTDSTIGAAFLVKSMVVDNINIKLEIWDTAGQERYRSLTPMYYRGAAAAVVVYDITKKNTFETLKRWVSELQKHASPNLILALAGNKVDLPNREVQVDEVNRYISELGNAIFFETSAASGQNINELFTEICRRLIENYK
Protein: Taste receptor type 2 member 3 (T2R3) (Q9NYW6)
Organism: Homo sapiens (Human)
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 2 member 4
- Taste receptor type 1 member 2
- Taste receptor type 1 member 3
Sequence:
MMGLTEGVFLILSGTQFTLGILVNCFIELVNGSSWFKTKRMSLSDFIITTLALLRIILLCIILTDSFLIEFSPNTHDSGIIMQIIDVSWTFTNHLSIWLATCLGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGALLLSCGSTASLINEFKLYSVFRGIEATRNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRHTRQMLQNGTSSRDPTTEAHKRAIRIILSFFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFYPAGHSFILILGNSKLKQTFVVMLRCESGHLKPGSKGPIFS
Protein: Serine--tRNA synthetase-like protein Slimp (Seryl-tRNA synthetase-like insect mitochondrial protein) (Q95T19)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential protein which may play a role in mitochondrial morphogenesis and function. Has transfer RNA (tRNA)-binding activity and can bind tRNA(Ser) but does not have serine--tRNA ligase activity and does not bind ATP.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:20870726}.
Interaction partners:
- Phosphoseryl tRNA kinase, isoform A
- serine--tRNA ligase
- serine--tRNA ligase
- Tyrosine--tRNA ligase
- Lysine--tRNA ligase
- Bifunctional glutamate/proline--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- Acyl carrier protein, mitochondrial
- Valine--tRNA ligase
- Glycine--tRNA ligase
Sequence:
MLSLRSVLKHCLSAKKTCSRNISALYITGDKANENYVTLQPYMDFNKTFGERQFLEQSISSRGLDIRLETVLSKYEKYKTHHAQLSKVAEERERVTKRLKELTKSGSSAVQLEELKEHGKSLRNELKALKQTLYPIEDDFIHDYLHLPNLLHVQCPVGGEEKLLYRHGIPKSENKTTSHLARQELVHFVDNNRYYLMEQAALFDVNAMQSLARYFVNHGHFIQTANPDFVRCVLLEANATPLSDYHLVQEEHLQNKINTAYLTGGASFESYLGAMTKLCVYPSVLPLRYVCCGRSYNRAEADLYGPIPSLYTATQTNAVQIFVATQTDNEADSQLEHILNLATDFYKALDIPFRISYATAADLTPAESIRAVIEVYAPSLQRYVCVGRISNYGDFVSKRILFSTRREKHYDFLHMVGGPVLYTSRLIAALVEHGVRLEDCKLLGSISQKPVHQQDLQQFKDLFT
Protein: Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein) (Q9Y2V3)
Organism: Homo sapiens (Human)
Function: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGAKERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPATGEAKLSEEEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLESWLGPPLPGGGATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPPPPSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQAIGKPWQAL
Protein: Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) (P11536)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus.
Interaction partners:
- Ecdysone-induced protein 75B, isoform B
- Ecdysone receptor
- Ecdysone-induced protein 78C
Sequence:
MIMVQHLVAASAHNFASQAAASLVNVSSSSSSSSSSSSSSLSLSSSSSSSSLSSATPTPVASPVTPTSPPPAAAAPAEASPPAGAELQEDGQQAKTQEDPTMKDQDMLEKTRQEVKDPVNVEEPGAIVDTESVMARQSPSPVASTKVPESLEEISNKSPPVQEDEEESESVASDCREFKVLYNHLRQQQHHHSPSSPDKTRSTLDDVSKILWERKQQLQRSSVITAAPTLQPQQHQQPMSDIEDEETLEDVDDADADVEADAEDEELLEQYQNGYDSPLDLSLGGATSAAASAAAAASAVSRRRGRTYSGTESDDSAQCERARMRLKPERKAERSAAYKKSLMKRYYTEIPIVKQSTSPAPQQQLQQQHHLQQQQQQQPHNGSTFAGATALLHIKTEQNTLLTPLQLQQQQQQQQGLHGAAGNGGSSNGNNAHQQQQPLAIPQRPLLHNLLSGGAIHNPHHRNYTTATTGSFPPSPADSGVSDVDSSSSGGQPCADELKARLGMPPATSASAAAAAAAAAAAAAHLHTGTFLHPNLYQNNAANSLRNIWNRSVGVPDNYYGSSGAGSGGTQPGGPGNPQTPGYLTTSYFNAPTAATAAASQRGTTINGYHSLHQQQQQQQQSQQSQQQQQLAHQQLSHQQQQALHQQLSHQQQQQQQQQQQHPHSQLNGPHPHSHPHSHPHSHPHAGQHTHSTIAAAAAAAAASVVSSSSSAVAAAAMLSASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLELGGFQQRKAKKPRKPKLEMGVKRRSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVDVPKDIIEIDCNGV
Protein: Putative ETHYLENE INSENSITIVE 3-like 4 protein (Q9LX16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor that may be involved in the ethylene response pathway.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ethylene-insensitive protein 2
- EIN3-binding F-box protein 1
- 2-oxoglutarate
- At4g31830
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 6
- Ethylene-responsive transcription factor 1B
- Mitogen-activated protein kinase 3
- EIN3-binding F-box protein 2
- At4g27530
Sequence:
MVEVEELEPLSPMDDEEEEISYDDLKRRMWKDRNLMEKKLKQQKRHSNDVVSFTTHRAEASRRKKMARSQDSVLKYMMKIMEVCKAKGFVYGIVPEKGKPITGSSDSLRRWWKENVQFDQNAPDAITDYLALAAAAAAAELIDKSSSSSSLLHMLQELQDTTLGSLLSALMQHCMPPQRRFPLEKGIAPPWWPTGTELWWGEQGAAHEHGAPPYRKPHDLRKSWKVSVLAAVIKHMSPNLGRVRRLARQSKSLQDKMMAKETDTWSRVLNQEEALLNIKDLKISEDQDDQESSGSKRKSESMEPSKSVYTCQNSSCPKSDVSFGFGDKNSRTGHEIQCLYGSNQEPSQSGEYTSSLLETVPSIVTNSTSEDDYYNVSSRALDKRDDDDHSINGNWMEYFWLEKMQQEFHCSRRFEDDEGTGTDFDQLTESDRSDNVNLNQLTKSDRSDNVNRSAFSVWDMGCEDKDIYMFD
Protein: Zinc finger protein-like 1 (Zinc finger protein MCG4) (O95159)
Organism: Homo sapiens (Human)
Function: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:18323775}; Single-pass membrane protein {ECO:0000269|PubMed:18323775}.
Interaction partners:
- Vascular endothelial growth factor B
Sequence:
MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNIPLASRETTRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNGPIFPPTNLAGPVASALREKLATVNWARAGLGLPLIDEVVSPEPEPLNTSDFSDWSSFNASSTPGPEEVDSASAAPAFYSQAPRPPASPGRPEQHTVIHMGNPEPLTHAPRKVYDTRDDDRTPGLHGDCDDDKYRRRPALGWLARLLRSRAGSRKRPLTLLQRAGLLLLLGLLGFLALLALMSRLGRAAADSDPNLDPLMNPHIRVGPS
Protein: Nicotinic acetylcholine receptor alpha6, isoform E (Q7KTF8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
- Nicotinic acetylcholine receptor alpha5, isoform I
- Nicotinic acetylcholine receptor alpha3, isoform B
- Acetylcholine receptor subunit alpha-like 1
- Acetylcholine receptor subunit alpha-like 2
- Nicotinic acetylcholine receptor alpha4, isoform C
- Nicotinic acetylcholine receptor alpha7, isoform E
- RIC3 acetylcholine receptor chaperone, isoform C
- Wing blister, isoform B
- Proteasome subunit beta
- Acetylcholine receptor subunit beta-like 1
Sequence:
MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ
Protein: Ent-kaurene synthase, chloroplastic (EC 4.2.3.19) (A0A075FBT3)
Organism: Marrubium vulgare (White horehound)
Function: Involved in the biosynthesis of labdane-type diterpenoid including marrubiin and other labdane-related furanoid diterpenoids with potential applications as anti-diabetics, analgesics or vasorelaxants (Probable). Terpene synthase that produces ent-kaurene from ent-copalyl diphosphate (ent-CPP).
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
IDESQTSLDTGVQRFTSSKIASSVQCFEDTKARIVKLIHKPELSVSTYDTAWVAMVPSPNSSNEPCFPDCLAWLLENQCCDGSWACPHHHPFLKKDVLSSTLACILALKKWGVGEEQINKGARFIEVNFASATEKSQISPTGFDIIFPAMLDYARDLFLDLRLEPTTFDNLIFRRDLELKRCYESHREAYLAYIAEGMGKLQDWESVMKYQRKNGSLFNSPSTTAAAFIALPNSGCLSYLHSALKKFGNAVPAAYPLDVYSRLRTVDNLESLGISRYFQKEIQQVLDETYRWWLQGSEEIFLDASTCALAFRTLRMNGYNVTSDAITKLLPDSFCGNMKDIGTTLELYRASEFILYPDEKDLEQQNLRLKDILEQELSSGFIHSEVNRALNYPFYAIMDRVAKRRNIEHYNFDNTRILKTSYCSPNFANKDFLFLSVEDFNNCQAMHREELKGKMRWVTENRLDELKFARSKSAYCYFSAAATFFAPDLSDARMSWAKNGVLTTVVDDFFDVGGSEEELKQLIRLVEIWDLDAITECSSQNVQIIFSSLKRTISEIGDKGFKLQGRSVTNHIIEIWLDLLYSMMKEAEWARDNHAPPMDDYISNAYVSFALGPIVLPCLYLVGPKLSEEMVRHSECHTLFRLMSTCGRLLNDIQTCERELKDGKLNAIPLYMINSGGETSKEAATQEMKSLIDRQRQELLRLVLTREGSLLPKPCKELFWHMSTVLHLFYCKDDGFTSQDLIKVVNEVIHEPVVLN
Protein: GCN5-related N-acetyltransferase 1, chloroplastic (EC 2.3.1.48) (Serotonin N-acetyl transferase 2) (AtSNAT2) (EC 2.3.1.87) (Q9C666)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:31698875, ECO:0000269|PubMed:32633465}.
Interaction partners:
- Phenylacetaldehyde synthase
- Acetylserotonin O-methyltransferase
- GCN5-related N-acetyltransferase 10, chloroplastic
- Acyl-CoA N-acyltransferases
- GCN5-related N-acetyltransferase 2, chloroplastic
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 8
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 6, chloroplastic
Sequence:
MFLGGTISTPPASLRLRSTLNPQNAVTQSSSQATFPAAMQRKPPSYSISDEDLESRGFLLRRTTEGLNLDQLNSVFAAVGFPRRDTAKIEVALQHTDALLWVEYEKTRRPVAFARATGDGVFNAIIWDVVVDPSFQSCGLGKAVMERLIEDLQVKGICNIALYSEPRVLGFYRPLGFVSDPDGIKGMVFIRKQRNKK
Protein: KH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI) (Q96PU8)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability. In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:37379838}. Cytoplasm {ECO:0000269|PubMed:37379838}.; SUBCELLULAR LOCATION: [Isoform QKI5]: Nucleus {ECO:0000269|PubMed:37379838}. Cytoplasm {ECO:0000269|PubMed:37379838}. Note=Localizes predominantly in the nucleus and at lower levels in cytoplasm (PubMed:37379838). It shuttles between the cytoplasm and the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; SUBCELLULAR LOCATION: [Isoform QKI6]: Cytoplasm, cytosol {ECO:0000269|PubMed:37379838}. Nucleus {ECO:0000269|PubMed:37379838}. Note=Localizes predominantly in the cytoplasm and at lower levels in nucleus. {ECO:0000269|PubMed:37379838}.; SUBCELLULAR LOCATION: [Isoform QKI7]: Cytoplasm, cytosol {ECO:0000269|PubMed:37379838}. Cytoplasm, Stress granule {ECO:0000269|PubMed:37379838}. Nucleus {ECO:0000269|PubMed:37379838}. Note=Localizes predominantly in the cytoplasm and at much lower levels in nucleus (PubMed:37379838). Shuttles between the cytosol and stress granules in response to stress (PubMed:37379838). {ECO:0000269|PubMed:37379838}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 15
Sequence:
MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN
Protein: Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Type II N-myristoyltransferase) (O70311)
Organism: Mus musculus (Mouse)
Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O60551}. Membrane {ECO:0000250|UniProtKB:O60551}; Peripheral membrane protein {ECO:0000250|UniProtKB:O60551}.
Interaction partners:
- Acyl-CoA-binding domain-containing protein 6
- Guanine nucleotide-binding protein G
Sequence:
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQSSKHNAIWQQISAGAAMGGDTMEGEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRRYQFWDTQPVPKLNEVITSHGAIEPDKDNIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKRMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKAVRELINIYLKQFHLAPVMDDAEVAHWFLPREHIIDTFVVENPSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMNDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ
Protein: Neurogenic differentiation factor 6 (NeuroD6) (Helix-loop-helix protein mATH-2) (mATH2) (Protein NEX-1) (Protein atonal homolog 2) (P48986)
Organism: Mus musculus (Mouse)
Function: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- T-box brain protein 1
- Neurogenic differentiation factor 2
- Fez family zinc finger protein 2
- DNA-binding protein SATB2
- Homeobox protein EMX1
Sequence:
MLTLPFDESVVMPESQMCRKFARQCEDQKQIKKPESFPKQVVLRGKSIKRAPGEETEKEEEEEDREEEDENGLSRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELATPPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQEETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAVFHN