wanglab/gogpt-training-data huggingface dataset:
Protein: Guanine nucleotide exchange factor subunit Rich (Protein RIC1 homolog) (Q9V3C5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21835342}; Multi-pass membrane protein {ECO:0000269|PubMed:21835342}. Note=Colocalizes with Rab6 at the Golgi apparatus.
Interaction partners:
- Uncharacterized protein, isoform D
- Ras-related protein Rab6
- ADP-ribosylation factor-related protein 1
- Conserved oligomeric Golgi complex subunit 8
- Protein MON2 homolog
- Golgin-245
- Probable trafficking protein particle complex subunit 13 homolog
Sequence:
MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQYGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDPPAASLKRDSAELFIKENIPRLSLRELCSVTLGSVITTVCCISLSELLLATQSCELLRLQWTELEHAENDLELPALSSIKLRDIPFYVQQQPQQSARNVPPLNRDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFWVPDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPDSLGSVNELKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFMLKLHPEKDKSNVLQLQFVKSALSMNPCMTTSPHILLQGDDCLYLNQGNNLELTYAGSHGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNYAATNWPIRYAAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMGCYSLLDRTDELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNMSKNSAYALDIECAYELDVKSICIHPACIVSLTVTNLKNELKPQGQLGGDQAETIIVNVCGRILMIQRDAGEQVPNTLLATCLASCVEVFWLSHSLERCAMRDCLWLYSGAHGMRVWLPILPPGRERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENESTLYANEQVSHFSLPFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIPDAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDPNEIDSPRSSMVVNVKIAPPPQVNTQQQVNQNADAFNMVLGPIARERSFSTTVTSNLPKDKQASGTPGVAPVTESSSAGAPSVVRRRSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFHLVSWLSQESERAAKLDDFAGALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTGGGGSSQTSESGYFSLATPNGAATQSPQLQPSIREEEEELQQPSSLPILKTRSGSQLSFDNFRYRRLYSLPTSEDDLAVDILPQKLSIKLRYLLQLFIEANCTDYALVLSILLQDAASISRIVNGIIRSESVHTCRRTESALKQLSQSTFEHSGSLYRGFVLTLQPHVYLLEQYIQSLGDAPCSQLQDAGPGTEQGVDVSTGLQGLQNEVGEFVPNSQQANGNQWTVADLNPNHQRLTRHASLESNGNAVVASGSSAHSTPTQRQLSRQNSREREGCRLM
Protein: DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (DNA fragmentation factor 40 kDa subunit) (DFF-40) (Q99N34)
Organism: Rattus norvegicus (Rat)
Function: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- DNA fragmentation factor subunit alpha.
- Caspase-3
- Endonuclease.
Sequence:
MCAVLPQPKCVKLRALHSSCKFGVAARSCQELLRKGCIRFQLPVPGSRLCMYEDGTEVTDDCFPSLPNDSELLLLTAGETWHGYVSDITRLLSVFNEPHAGVIQAARQLLSDEQAPLRQKLLADLLHHVSQNITAETREQDPSWFEGLESRFRNKSGYLRYSCESRIRGYLREVSAYISMVDAAAREEYLRVLSSMCHKLKSVQYNGSYFDRGAEASSRLCTPEGWFSCQGPFDLESCLSKHSINPYGNRESRILFSTWNLDHIIEKKRTVVPTLAEAIQDGREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLQCDRSRIYRPQTGSRRKQPPRKQPPRKRPPRKRQ
Protein: Trafficking protein particle complex subunit 11 (Q8IRE3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222}.
Interaction partners:
- Trafficking protein particle complex subunit 2-like protein
- RE19263p
- FI18195p1
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Probable trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 6B
- Probable trafficking protein particle complex subunit 13 homolog
Sequence:
MTMDATALPSELLVTPQPLVGFCGLDTARVSVHKAVWEAFSGSLQRKAADRAAVQYKLLPPNYEFPVAKPKRASYEWYHPKGILKRNWMLKHLHVLPSVVVLFQDMEWNDLQWTEKQVQCAAIVQALKNTLQERNTRLCLVLLQRAAPLPPGEDLLAAERAASLTNACGITSKMLFILPHTEHLTGYALRLESAFLDMAQSYYALMSKRIRNHRDQLTAAHTSLKIRHQFKLGFVAEMRQDFSTGQKHYFQAYANLDEIRINDGNCLEIKTLAGFLNYKICRLMFKLKTPRDAINQFIIHVEKHKSRVGFKDLAFEHHAWLSTQHSVFAELFCEAIKNGLPALQTQHPGIYYHKAAEFVMKRRDAAMEAYAAMQASSEATPTPIQNPLSLYTEFFGIRAVKTGDLVAEQQANMQLCDQERSYNHSAAIIALLSQAMAQFKIYKCLRFRKKLAIDMAEEYLKSGDHAKALTLYSLMLPDYRQEKWTTIFTDVLLKTLRCALLSGSVADYIACSVEALSLRHQSDQSERILILENLWQVFQGVPPMPKTQLTPEAQALWTSALANVKSPIQIDLDKVNDVVEMCATFERVQLSNDDLLQLQLIVRVLTDIPLRIRSFHVILADAGNPQNSYKLEALKYFCFPTLTQLRGQKQPDDEQLENPSQEPKNFEKNMRLEPGSYYQLFCSTEAQQFHENTQLRIVRLEAHMGTDQVAALLTCSSNYSRQLFRHHTRSRDLDDNVTINPICYIAPTFHLDTQTNLGHGHDNGLTDDKEMVATKMLVNEYFPVVTTVSNPYNVYLQNVGVHISIPVGLRNSVFLTTDISPGRQKLHSQIQIDVGELSAHGSNTATFYIFSLTEAEIKLAQRLSYTLDVDRGPGGGGSNARVSTAPNSSESTPDHEVKSVIPSVAAISPVQIEYLDETRLRKSREDTLTVRCYGDFKFNARFYTMDRKPLNQVYRGENFLLRANTEVVAVDDVEILDSFFICDHNLVQSNYSFKQKKYTNKYSAGEQLESVIVLRTNATLRDWATARDLDHRGKLEGKAVASKFIRPVPKPSSEEPLAPTPPAGISAYMSKSLVTKIPTTMTIINSNSAVSNALQVANAGVMSNSTQSDDVNVAEEAINTHEGIKTTRLIYNKALEAVQGTGHCRGFIKKIYTLEGNPSAVPIFGVFCIRWRRANCKEENESKFVIRGLDIAEPPLNIYCTIEEKMFVKMPMAFKVVLKNPTTHVLHLIANLSISKTDNFICSGHKQLDISIMAYEEKELVYNLYPLQVGWQELPVLSLEYNTKADPQKKDSQNALLDELVQRALPKRVFVLPPLKQQNK
Protein: Rho family guanine nucleotide exchange factor (A0A1D8PNB5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Phosphatidylinositol-3-phosphate-binding protein
- Cell division control protein 42 homolog
- Rga2p
- Cyclin-dependent protein serine/threonine kinase inhibiting protein
- High osmolarity signaling protein SHO1
- Ras-related protein RSR1
- Rho family GTPase
- G protein subunit beta
- Serine/threonine-protein kinase CST20
- Ras-like protein 1
Sequence:
MEHPPAALRTFSTQSTSSLNSVSTVSSSRIVSSGPVNINNFNKPSTPKDHLFYRCESLKRKLQKIPGMEPFLNQAFNQAEQLSEQQALALAQERSNGNGHSNGKRHQSLDGAMNRLSVGSDSSSIQGSLTRMATNASTSSLISGMPNNNTLFTFTAGVLPANISVDPATHLWKLFQQGAPFCVLINHILPDSQIPVVSSDDLRICKKSVYDFLIAVKTQLNFDDENMFTISNVFSDNAQDLIKIIDVINKLLAEYSDASDSGGGDEDVNMDVQITDERSKVFREIIETERKYVQDLELMCKYRQDLIEAENLSSEQIHLLFPNLNEIIDFQRRFLNGLECNINVPIRYQRIGSVFIHASLGPFNAYEPWTIGQLTAIDLINKEAANLKKSSSLLDPGFELQSYILKPIQRLCKYPLLLKELIKTSPEYSKQDPHGSSSLTSFNELLVAKTAMKELANQVNEAQRRAENIEHLEKLKERVGNWRGFNLDAQGELLFHGQVGVKDAENEKEYVAYLFEKIVFFFTEIDDNKKSDKQEKKSKFSTRKRSTSSNLSSSTTNLLESINNSRKDNTLPLELKGRVYISEIYNISAPNTPGSTLIISWSGRKESGSFTLRYRSEEARNQWEKCLRDLKTNEMNKQIHKKLRDSDSSFNTDDSAIYDYTGISTSPVNQSTQQQYYDHRGSHSSRHHSSSSTLSMMKNNRVKSGDLSRISSTSTTLDSFSNNLNGSPNTTNPSLTSSDATKTIPTFDVAIKLLYKSTELSEPLIVNAQIEYNDLLQKIISQIITSNLVADDVNISRLRYKDDEGDFVNLNSDDDWGLVLDMLTSEDFYQTSSNEKRSVTVWVS
Protein: Pluviatolide synthase (EC 1.14.19.72) (Cytochrome P450 family 719 subfamily A polypeptide 23) (L7T8H2)
Organism: Sinopodophyllum hexandrum (Himalayan may apple) (Podophyllum hexandrum)
Function: Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family. Catalyzes the conversion of matairesinol to pluviatolide.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEMEMSVLAMSSTLILALAMALIFLFKAKSSSAIKWPPGPKTLPIIGNLHQLGGDELHIVLAKLARVHGAIMTIWMAKKPVIVVSDVNSVWEVLVSKSSDYAARDAAEISKIVSASSHSINTSDSGPYWQTLRRGLTHGPLGPLNISAQIPIQQRDMQRVIREMQQDAAANGGIIKPLDHLKRSSTRLVSRLIFGDTFDNDPYNDSMHEVVQDLNRFGGIALLEQAFSFAKHLPSYKRGVKEFHIHKRKIDDLVRPVVASANPPSNSYLGFLQSQNYSEEIIIACIFELYLLAMDSSASTATWALAFMIRDQQVQEKLYQDIKRVIGDGVDLVKAEDLSKMHYLQAVVKETMRMKPIAPLAIPHKTAIDTTVMGTKVPKGTCVMVNLYALHHDESVWAKPYTFMPERFLQGEDGKSVTEQAFLPFGAGMRICGGMEVGKLQFSLALANLVNAFKWTSAAEGKLPDMSDELQFITVMKTPLEARIIPRNP
Protein: At5g19860 (Q7XA63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MALYPFFISIFIFSLTLFTTTTHSLNEPDPDSISTVYELLPKYGLPSGLLPDTVTDFTLSDDGRFVVHLPNSCEIEFDYLVHYDKTISGRIGYGSITELKGIQVKKFFIWLDVDEIKVDLPPSDSIYFKVGFINKKLDIDQFKTIHSCHDNGVSGSCGDSWKSFLEKGQGMMDEAEMLITE
Protein: MHC class II H2-M beta 2 chain (Q31113)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLDCMGAGGFVAHVESTCVLDDAGIPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIQRLQNRLQDCATHTQPFWDVLTHRTRPPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGQH
Protein: Basic leucine zipper (bZIP) transcription factor atfB (Q2U616)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Transcription factor that acts as a key player in the regulatory circuit that integrates secondary metabolism and cellular response to oxidative stress (By similarity). Regulates the genes involved in development and stress response through direct binding to their promoters. Particularly involved in the resistance to oxidative stress in asexual conidiospores.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- BZIP domain-containing protein
Sequence:
MSVDQTLYSRTPTAMADPTCAGPAAFTAAGAFSQPDLMAFSLREEEPIWGFDTIAPSMASWQGKMEQQTFCNPNMERGLKNTHVRNGQPTPPPFDDKKLQTPMGEMYPVAQYAFNSSPPEYAPPKHRSSLSEQSQTDGYGVSTRRRKASAIDQCEQQQEREKREKFLERNRLAASKCRQKKKEHTKLLETRFREVSNKKGELESEIEHLRSEVLNLKNEMLRHAQCGDEAIKIHLAQMVRLITSKDTPNRDLVSPMRSPEQMAASTPHGLSFGFDGPMQLPSEMGSPLDQRRDSEQSIMTESSYTFSTDDSFEELINV
Protein: Homeobox protein mls-2 (Mesodermal lineage specification protein 2) (Q18533)
Organism: Caenorhabditis elegans
Function: Transcription factor that binds to the promoter of target genes. Regulates fate specification and/or differentiation of multiple cell types arising from the embryonic mesodermal (M) lineage and the ABp(l/r)paa precursors. In the postembryonic M lineage, regulates cleavage orientation, cell proliferation and cell fate specification. Regulates hlh-1 expression to specify coelomocyte fate in the mesodermal (M) lineage. In AWC neurons, initiates expression of ceh-36, leading to the expression of terminal differentiation genes. Regulates ventral cephalic sheath (CEPsh) glia differentiation and expression of transcription factor hlh-17 in CEPsh glia. Promotes terminal differentiation and morphogenesis of the epithelial duct and pore cells. In the duct cell, cooperates with the EGF-Ras-ERK pathway in turning on the terminal differentiation gene lin-48.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:16107479, ECO:0000269|PubMed:18508862}.
Interaction partners:
- T-box transcription factor mls-1
- Homeobox protein ceh-36
- C2H2-type domain-containing protein
- Dystrobrevin-1
- Protein isy-1
- Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein
Sequence:
MPTSVMNLPIDMTTMSSQERLEKMSQLPKIELMEEEEEEEMKPSSDNKIKFNISELLEDDRKPTTQSSPSASSEDSTNEIEQTAFNFNFDPKMNPISALLQLQQTFLNVGNQQNMISPLTMFPFFGLPTAQLMHFKNMSNPDVNIQSDNGEEKDEKSEGKDGETRDSTGGSPLESDAEDDDDIGRGSDDEANSSDPSQNRKKKTRTVFSRSQVSQLEMMFECKRYLSSQERSNLAQKLHLTETQVKIWFQNRRNKFKRQAQTDDTNISLQMHRANVFSIPATTALTSPILTIPTTSAGVNMRNMISSPMDASATAAARFLFGFGTLQAQQNLNASAQAQNM
Protein: Macrosialin (CD antigen CD68) (P31996)
Organism: Mus musculus (Mouse)
Function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Subcellular location: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Lysosome-associated membrane glycoprotein 3
- Lysosome-associated membrane glycoprotein 1
- Adhesion G protein-coupled receptor E1
- Scavenger receptor cysteine-rich type 1 protein M130
- Allograft inflammatory factor 1
- Receptor-type tyrosine-protein phosphatase C
- Glyceraldehyde-3-phosphate dehydrogenase
- Triggering receptor expressed on myeloid cells 2
- Integrin alpha-M
- Glial fibrillary acidic protein
Sequence:
MRLPVCLILLGPLIAQGTEEDCPHKKAVTLLPSFTMTPTATESTASPTTSHRPTTTSHGNVTVHTSSGPTTVTHNPATTTSHGNATISHATVSPTTNGTATSPRSSTVGPHPGPPPPSPSPRSKGALGNYTWANGSQPCVQLQAQIQIRILYPIQGGRKAWGISVLNPNKTKVQGGCDGTHPHLSLSFPYGQLTFGFKQDLHQSPSTVYLDYMAVEYNVSFPQAAQWTFMAQNSSLRELQAPLGQSFCCGNASIVLSPAVHLDLLSLRLQAAQLPDKGHFGPCFSCNRDQSLLLPLIIGLVLLGLLTLVLIAFCITRRRQSTYQPL
Protein: Peroxisome proliferator-activated receptor alpha (Nuclear receptor subfamily 1 group C member 1) (A6XMH7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MVDMENRYRPPSPLDDSVLDSALFVRGMEELRDISQSMDEDALSSFEMTENQSGLGSGSESSTELDALTPASSPSSGVYGCPVGQDEFTSTSLNLECRVCSDRASGYHYGVHACEGCKGFFRRTIRLKLEYDKCERRCKIQKKNRNKCQYCRFQKCLSVGMSHNAIRFGRMPQSEKLRLKAEILTGERDVEDDQKTLAKQIYEAYVKNFNMNKSKARTILTGKTSTPPFVIHDMETLQLAEQTFVAKMMGSCGGLLNKDPEVRIFHCCQCTSVETVTELTEFAKSVPGFSNLDLNDQVTLLKYGVHEALFAMLASCMNKDGLLVAYGSGFITREFLKSLRRPFSDMMEPKFQFAMKFNSLELDDSDLALFVAAIICCGDRPGLVNVPHIERMQESIVNVLHLHLKSNHPDHGFLFPKLLQKLVDLRQLVTEHAQLIQEIKKTEDTSLHPLLQEIYRDMY
Protein: Thioester-containing protein 4, isoform D (M9PDF6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKLCDICEGDDCKSKC
Protein: Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) (Q01992)
Organism: Rattus norvegicus (Rat)
Function: Cleaves proteins, imported into the mitochondrion, to their mature size.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Mitochondrial-processing peptidase subunit alpha
- Mitochondrial inner membrane protease ATP23
- Mitochondrial-processing peptidase subunit beta
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit Tim10
Sequence:
MLLAAGTRYAYRLCGRRAAAALQGRAGRSCARSVSTSWSPVGAAFNVKPQGHLWDLLGERRGLFGVPELSTPEGFQVAQEEALRKTEWLVERACSTPPGPQTVLIFDELSDCLCRVADLADFVKIGHPEQAFREAAQEACRSIGTMVEKLNTNVELYQSLQKLLDDKKLMDSLDAETRRVAELFMFDFEISGIHLDEEKRRRAVDLNVKILDLSSAFLMGTNFPIKIQKHLLPEHIQHHFARDGRHLVIDGLHAEASDDLVREAAYKIFLYPNADQLKCLEELLSSRDLLANLVGYLPFPTGPPGTIAQTPETVMQFLEKLSEKLCERTRKDFEMMQGMKTKLNPQNSELMPWDPPYYSGVIRAERYNIEPSLYCPFLSLGACMEGLNVLFNRLLGVTLYAEQPFKGEVWCIDVRKLAVVHESEGLLGYIYCDFFQRANKPQQDCHFTIRGGRLKEDGSYQLPVVVLMLNLPHASRDFPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFSNDYRVVSQFAKHYQTGQPLPKAMVSRLCESKKVCAAAEMQLQVFYAALDQIYHGQHPLKKSTTDILMETQEQFYGLPYVPDTAWQLRFSHLVGYGAKYYSYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGKEPMLMIQGMLQKCPSIDDFVDALVSDLNLDFETFFMDSK
Protein: Growth arrest and DNA damage inducible alpha (Growth arrest and DNA-damage-inducible 45 alpha) (A5JUZ3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVIHIHLNGRILP
Protein: LD44304p (Q95TK6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWETMDFCNEVCLGSYQRTIGSTCETCKQEVSSIALGKYCVRFGFDVRQFCCAGCLNTFKKGLKTCSCCQKDISGGQEGFLAPVGDKDQFKDFCSQSCLRRYESMCNPRRKLRTDVCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAFKFVSNVNADPCAMCSKYFERRSAESYTIYNEQQSPKVFCSRVCINVYIIVNRHIVSCQWCKVKKYNFDMIYQIGGPHDQETLTCSINCLTMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQNQFARAPLTLDSDLPPSSAGSSKSQQQSNRGNKNAAPFPTGLPKRVKLKLSHTGKGGVGGKKSGSGTMLPVISTVQSLASGETEARIGNLTVRRKRGRPRESGTSSPPLSMPGVHPPAQRGRPRKHAVDYSARSPSPTMSGGSSHMGIPVRRNTTTTMDFGPATVTETKIITVPPYPKAVRNVNISCKPLTVTQGEQCSPDVRDCATQTEKDYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEKHESDSDSDNEIKPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNPYGDDMLQIALKMATGDYDNHHQTSTVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTFGVNAWKQWVMTKNADIEKSSMRRRPFKTELLQMTADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVARKFSVLYNDSQYIVTRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIMKHWKRSSQNSKVPGSRNVLLRFYPPQAGLDANPRKKKVYEQQENEENPLRCPVRLYEFYLSKCPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEINIALLTT
Protein: FAM172 family protein homolog CG10038 (Q95RN0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWSRLIQIFRPLRSFRMSHSPPPASNCEEALIQLKNFGYAFDGEGVLRKVDPATGEPGKELFSYNVSDDAAENEKHYQKLANQIPEIVYALLEKNGLSRTYIPFDQPPERSSFVFSQPAKLSQSKKLLVLIHGSGYVKAGQWARSLIINNSLDHGTQLPYVRQAQKLGYDLLITNANDCTRFYNGKENPIKGVNTSVEHVKYVWKNIVLPAKPESVAIVAHSYGGSLTLDLVERFPDFFKESVFAIAFTDAAMGSPQAKNKEYLCDVACDWVASNTPLDTPVSQSKSSIRRISAGHTKHEWTSYSAIDSVFKFIEEKYEQRANKK
Protein: Phenylcoumaran benzylic ether reductase Pyrc5 (EC 1.23.1.-) (Minor fruit allergen Pyr c 5) (allergen Pyr c 5) (O81355)
Organism: Pyrus communis (Pear) (Pyrus domestica)
Function: Oxidoreductase involved in lignan biosynthesis. Catalyzes the NADPH-dependent reduction of phenylcoumaran benzylic ethers. Converts dehydrodiconiferyl alcohol (DDC) to isodihydrodehydrodiconiferyl alcohol (IDDDC).
Interaction partners:
Sequence:
MASKSQILFIGGTGYIGKFIVEASAKAGYPTYVLVREASLSDPAKSKVIENFKALGVNFVLGDLYDHESLVKAIKQVDVVISTVGHGQLADQGKIIAAIKEAGNVKRFFPSEFGNDVDRSHAVEPAKSAFETKAKIRRAVEAEGIPYTYVSSNFFAGYFLPTLNQPGASSAPRDKVVILGDGNPKAIFNKEDDIGTYTIRAVDDPRTLNKVLYIRPPANTISFNELVSLWEKKIGKTLERIYVPEEQLLKNIQEAAVPLNVILSISHAVFVKGDHTNFEIEPSFGVEATALYPDVKYTTVDEYLNQFV
Protein: Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC 6.2.1.2) (Olfactory specific medium-chain acyl CoA synthetase) (O-MACS) (Q80W40)
Organism: Mus musculus (Mouse)
Function: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q7TN78}.
Interaction partners:
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MKVLLHCQRLRFIWLAKPAGRHFHRDSQLWAPLTLDDFEAINRCEKPLPKNFNFAADVLDQWSLKEKSGERPANPALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQASKAKCIVASEEVAPAVDSIVSECPSLKTKLLVSPHHWDGWLNFQELLQSASEEHNCVETGSQEPMAIYFTSGTTGSPKMAQHSQGSLGIGYTLCGRYWLDLTSSDIMWNMSDTGWIKAAIGSVFSTWLRGACVFVHRMAQFDTDIFLDTLTTYPITTLCSAPTVYRMLVQKDLKRYQFKRLRHCLTGGEPLNPEVLEQWKMQTGLELYEGYGQTEVGIICANRKGEAIKPGSMGKGVVPYDVQIIDENGNILPSGKEGEIALRLKSDRPFCFFSEYVDNPEKTDATIRRNFYVTGDRGVMDDDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPYKCSNREKLTAELQDHVKNSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWGRA
Protein: Sister chromatid cohesion protein dcc1 (Defective in sister chromatid cohesion protein 1) (Q09732)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is formed where ctf18 replaces rfc1 in the RFC complex along with the association of dcc1 and ctf8. This complex is required for efficient establishment of chromosome cohesion during S-phase. Acts as a PCNA loader, loading PCNA onto primed templates.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Chromosome transmission fidelity protein 18
- Replication factor C subunit 2
- Replication factor C subunit 5
- Replication factor C subunit 3
- Replication factor C subunit 4
- DNA polymerase epsilon catalytic subunit A
- Telomere length regulation protein elg1
- Structural maintenance of chromosomes protein 3
- Chromosome transmission fidelity protein 8
- Swi1-interacting protein swi3
Sequence:
MEANEERCILLKYPHPSSDISSEYLLLELDDDLLKTLEENPEEEIVFKSDFDKKASVLCTSDKTYAVRQVVQSNSYLLFDELSPTDWVLNDTCYSFLEVERIYGFIFSDDKISYWDEDSVELKPISLTKDQFIRSVPASRNEVDSFLQKNFFMVKNEFLYRLSPSYICSIIDWIFVIAQQLHIDFASFEFKILKKPAMDDEFDWDSVICVLESISSPIKDNVLPKKFNIDLELTTFWYGRFLLEGINSISSDEFIQLWDNRLPYPCKGLPSLNLLKGYYFHDTPNTIQYLSGDQLPREPSRRFQSLFQLKSKWLYEELWSFVKDLALSKSRVEALILKYGRKQTSRDGVYINSRGTW
Protein: SUZ12 polycomb repressive complex 2 subunit (J3QQW9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL
Protein: Exonuclease 1 (EC 3.1.-.-) (Q8L6Z7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA mismatch repair protein MLH1
- DNA mismatch repair protein MSH2
- DNA mismatch repair protein MSH6
- DNA mismatch repair protein MSH5
- DNA mismatch repair protein PMS1
- DNA mismatch repair protein MLH3
- Crossover junction endonuclease MUS81
- Double-strand break repair protein MRE11
- DNA mismatch repair protein MSH3
- ATP-dependent DNA helicase Q-like 4A
Sequence:
MGIQGLLPLLKSIMVPIHIKELEGCIVAVDTYSWLHKGALSCSRELCKGLPTKRHIQYCMHRVNLLRHHGVKPIMVFDGGPLPMKLEQENKRARSRKENLARALEHEANGNSSAAYECYSKAVDISPSIAHELIQVLRQENVDYVVAPYEADAQMAFLAITKQVDAIITEDSDLIPFGCLRIIFKMDKFGHGVEFQASKLPKNKDLSLSGFSSQMLLEMCILSGCDYLQSLPGMGLKRAHALITKFKSYDRVIKHLKYSTVSVPPLYEESFKRALLTFKHQRVYDPNAEDIIHLCDISDNLGEDSDFVGPSMPQDIAKGIALGQLDPFTQLPFQAESVTPKLAVDDISRPKSFKPETVKKKLDLPVQKNLLTKYFCFASVEAKRKFKAPRISPMSLTPTDESPSIPDDNTPDLDALSSQTTNESPVYSLGENPCVSEVAEKRDSPDDDAVERNHKDLHHKYCEREVDRPKSDSLKVIVRSKYFKQKQEDKSLKQSIPCLNDCSVIGQRKAVKTVINMSSASKREESHRAIATSPCLHHDRIYNDHEDAKEASFSAMNEVAERTINTHKINHQINEEEQNPSVEIPSAFSTPENVIPLSSIAIDSCHGVATGKRKLDSDENLHKENLKSKHMRMDETDTALNAETPLETDDVEKFGSNISHIGHYSEIAEKSVERFVSAISSFKYSGTGSRASGLRAPLKDIRNTCPSKGLSLKPDISKFGYASSNRHMVTKSRRM