Protein: Inositol 1,4,5-trisphosphate receptor-like protein A (Q9NA13)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Calcium uniporter protein, mitochondrial
- Calmodulin
- Myosin-ID light chain
- Calmodulin-like protein
- Myosin, essential light chain
- Myosin-IB light chain
Sequence:
MEEKNVNLKTGDLVTFFSEQEEEDGYFSKSHDSAVMSNNKSKDCVFKVYPFTQYTARKALKKKAKRKLQQQQADGADANNTNSSSGGGNSNNNNNNNSNSSNNNNSSNNNNNNNNNGTTNANGENVNNEVTDLELKQLEEYQDLEDVSNESTLIQLEGRDLVYGQIVQLYQPSSNQFLFARNNIVGFRQDGSQKCYFKITPRFQNQDGCKVFSEDLVLLRHEKTGLFLNQQNFIIDQGVFGIGLSENGTFWKMAVSDVDGKSGLNILKANEPFRLFHREGGFVKVSNDKTTFTYNTKTPSSINSLFEIEFENNNLISPLLRSQKDLQLQQKDNTDQLQQQQQKDKDKDNPLKQSYGSLSNSNILLQNNNNNNNNNNSNNNNNSNNNSNNSNGNNSNGNNNNNNSNNIFTSNEVHIGQSFWIRLVGTKKYLSLKESSDDSLKDNPLIVVTEDQKYSPSATFSFVKRDKANEDVIFGSFVRIQSLSKQYLHFISDETFHHNGELVGSKKYYKNDDFQIKQIPKSQLEDYGFVLSRINKIQNYLYQSSSNSSSSLMSSINGIGQSSFSSLAGATTTTTNSGGSNNINNNNNNNNNNNNNNNNNNNNNNNNNIDKKRATVQEIKAIIVEFIKFCTQSEVEDPLDREGTPIKTHQKLLSHPSHLSVLLDYLKRLFEPFDPASILFVYRLLKQMAKSNIKNGIIINEHLDQISPPSIRDKTIPLHFGAILYEVYKNNNILLEALTEDKVQEFINVIKQKKEPKYMELLSEICICYGKPIVKNQQYLCDLLLEKNSNLLFKTRVIGGSLEIERQNPAPKWVDITAFALSVDEKTHRYFEQSLALYSNVSKGRNYNGIRLVGQRITHKECLLALKEESLPYSLRGCYINILIHVYMDCHPQHYVPQINYVWNPSIVNNTKTIELLQLYQQYNITGSLHQRNSSIQNPYSTVSNGNISISSNNPISTTNTTTGSGGGGGGSGFMPTVGPSYGQASSPLSNGAIVNSLASTNLNNQTPTSLNLFNLNSPNNTTTTTNNSTNNTTNNNTNNNNNNNNTNSLITSTTHLIQLVSPQQNNNSNNNNNNNILNSIPTSPIVGSTNHGQLSHSGSNQTPLYQQQQQQQQQQQQQNSLSLFREDDIFSTFVNLEIQADKEPSTTTQLLISLLSKSEYFSNFNNGFPTSHRPQLAFFHKILIAVGYAFKFGFFRKKERVLLKRLRYILEFEHEPVNTFKEVDLGRTMGGSRMLEDESVIYVSIKIEIVNILHLMLSFQKKNIMDVFLYDFSNMSQSAFSQPENVKNQLIDRLTTNYQRDGHQDLSLCTVLFKLLKHENNQLSSLSLSLLNRIYKYRSIYAMLWSPIQKLFLLPNELTPTYKESLQKMESLTVTCFAPLTDDSTQESLRSLAFFIHLVTDSDPIKLVKNQKLLHVIGVHKTIIGVLKIGCSLDDLILDQSQPQHSQQQQQQHQQQPINISGSIDESSSTIPPLTTTTTTTTTTTTTTTTTQQSINFKSLLNSKTNSQSIHVAKIFRSCYEFLKVFCRDNRENQKVLFGEIEFLIGHLIRYGNVFGTVETLIEVFKNNIELAINFGNSPYLKLLVKFIINLSIDQLDPMFLRLLSVLILPCNENSVIENQISVTNLFKEYKSKISKLLVPISTMKEVMKDPKLLSKHYNVNSSNVYKLHLALQEILNHSLNDDGAGIGIGTTVIGGSIIGGSITTTAQTNINTITNTPTNNNSNNSNNNNTTNNNGTISHRHSNSTNTTQSVYPRLIRSSAKAQIVNSSVEILPKEFVINLELILLLKACSHGINTPTEVICREFLSMGECFDILIVRSDGNGKENSSLMINETKEYLENNLLFRFKSAYLSFLHEVFFNSDTLKGDLLALQLNHDLWSLIDQFTNQLNHLVTICAMNQMGQLYYVQMARNIIIPMVSVLERFYSQCFYFDKATQIHLTYSGRLMASLMKLYWKDPSLTIPFNQQNTSRYQSSLNMSPTNYDDSDTSEGGYHPILQGLDPEERVNIYSNLVKCLKAMDRSALSPIVPASVSTINISNVIKGCEDVINRTEHPNSRNRTETIDSSNSSPPLILSKSSSIYIDFTRLNNFVKLSKIRGYTEIAMMVNQSLSITPFIISHPNYNSNNSNNGNNNNNNNNGGGGNGNGGTIRSNSYISGGGGGSTTKRRTSRNNSNISDISNSGKGGSTISNRFQNSFSNTFIQQQQIGITNQRHINSGNTNIVTTVTSKSTNFLEILVFQLRNSLYDNDEMKINCIRILSSLLYINKERKPDIQNIMTDLYCHSAVIGLLSSKNIEIQFESLSLLLALLDDSVNVDNPLPNPKVKDDIQSHFSSSPDIQFFRDIYAMIERAKINLRDTKRNIHRIEHVKMGNNTVLGGNLTSKNSIKSSINNGNNSNNNNNRNGRVIDGCETNPYSTEFQLLQNIFRVLQLLCQGTTNIFKKSIRSQPDNYKSYDILKEMCQFLKILETIVNIDSDSIELGLRFFACMKEIVKNTPENQIAVTNVQVCKAVCNILKKTKENDPSKELKELKYLDLKIEVVDFLLHVIDKEDPRVMSKLIPELDYKVIESNTQVISQRSNHETNEKSIKLASMTFRLIKILADNDKSHNIQLEDCLLKCGEHCKSRIGRVELLYQNKLERIYFPIPNYSRRLILEDKEQSKIKNDENLLQENLEEHFINNKISWNKATEKIDAFMDYSEYKLIELEHLHNLKLNSMSYYLVSHTDKFKFLSFFLALIINLLLIIYSINSPPDLKQFKSDISDDYGIASWWAGFLPLTILQTICCILACVGFFLRKGPVLLYQNWVNYLKTHGHKKNFMFYTNDQRMHSLRQTFKYKFIPLNAKFLMTDLKAVYNILAVICSVLGIIYSPYFFAFHIFQFSLNTKALSLVLKAITMNKKTLLVMGVFILQAIYLLSIFSFVWFQEHYKDDDSEYMCGSLLQCFITNLYYGVPSQGQLIQFIKYNFPNNYLNTTDSTGSPTLEPIKTSNTVSARIIGWTVFNVAFYVVISLILLNVILGIIVDTFGQLRDQRAETEDYKSNVCFICSIERETFQKNSIEFKKHIEDDHNKWHYLYFFAYLKERCTNNQMNQLSELECSIADGITNRSYISFFPIEMSMSLQGIENANRKKEESIDQHAKLLDDVEKKITHNISTQFNQSISLLIDEIKNLRQQVSDLKQQQK