wanglab/gogpt-training-data huggingface dataset:
Protein: NACHT, LRR and PYD domains-containing protein 4F (Q3UWL9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MASFISDFGLMWYLKELNKKEFIKFKEFLIQEILKLKLKQISWTEVKKASREDLANLLLKCYEENQAWDMTFNILQKINRKDLTERATEEIADSSPLGLTDSGNPKLYRDHLKKKLTHDCSKKFNVRIQDFIKEIFIQNDCDTFENLLISKGTEKKPHMVFLQGMAGIGKTMMLKNLMLAWSKGLVFQNKFSYTFYFCCRDVKQLKTASLAELISREWPSPSAPIEEILSQPEKLLFIIDSLEGMECDLTKQESELCDNCMEKQPVSILLSSLLTRKMLPESSFLLSTTPETFEKMEDRILCTDVKTATAFDERSIKIYFHRLFQDKIRAQEAFSLVRENEQLFTICQVPLLCWMVATCLKEEIEKGGDPVSVCRHITSLYTTHILNLFIPQSAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFGEEALRRNGILDSDIPTLLDIGMLGKIREFENYYIFLHPSVQEVCAAIFYLLKSHVDHPSQDVKSIETVLFMFLKKVKTQWIFLGCFIFGLLQKSEQEKLVVFFGRRLSQKIQHKLYQCLETISGNAELQEQIDGMKLFCCLSEIEDEAFLVKVMNCMQQINFVAKNYSDLILAAYCLKHCSTLKKLSFSTQNVLNEKGNQRCMKKLIICWNDMCSVFVRSKDIQVLQIKDTSFNEPAIRILYEYLKYPSFTLNKLVANNVHFFGDNHAFFELIQNCSLQYLDLGCSFLTHSEVKLLCDVLNQAECNIEKLVVSHCKLSPDDCKIFGSVLMSSKTLKVLNWAYNNLNQGISLLCKAWCHPDCILEYLVLANCSLSEQCWDYLSEVLRQNKTLSHLDISSNDLKDKGLKILCRALTLPYCALKSLYLNNCQITARGCQDLAKVLRNNQNLKCLHISNNKLKDAGLMLLCKAIKHPNCHLEDLRLEACEITGASNEDLRYAFMQCETLQMINLMGNALEIVDY
Protein: Alpha,alpha-trehalose phosphorylase (TPase) (EC 2.4.1.64) (Q8L164)
Organism: Thermoanaerobacter brockii (Thermoanaerobium brockii)
Function: Catalyzes the reversible phosphorolytic cleavage of trehalose. Phosphorolysis is specific for trehalose, but D-xylose, D-galactose, L-arabinose, D-fucose, L-fucose, D-glucosamine and 2-deoxy D-glucose can act as substitutes for D-glucose in the synthetic reaction.
Interaction partners:
Sequence:
MANKTKKPIYPFEDWVIRETQFSIDTNYRNETIFTLANGYIGMRGTFEERYSGPKNTSFNGTYINGFYEIHDIVYPEGGYGFAKIGQTMLNVADSKIIKLYVDGEEFDLLQGKILFYERVLDMKKGFVERKVKWESPTGKILEVKIKRIVSLNRQHLAAISFTMQPVNFTGKIRFVSAIDGNVSNINDSEDVRVGSNLKGKVLKTIDKSVEGLKGWIVQKTQKSNFSYACAIDNVLVADSKYEVSNSLEEDGVKVIVDLEAEKGTSYTLNKFISYYTSKDFDENKLVALALEEIEKAKNDGFETIEKEQEEFLNSFWKDADVIIEGDKALQQGIRFNEFHLLQSVGRDGKTNIAAKGLTGGGYEGHYFWDSDIYIMPFFLYTKPEIAKALVMYRYNLLDAARSRAKELGHKGALYPWRTIDGPECSAYFPAGTAQYHINADIVYALKRYVEATNDVDFLYDYGCEILFETARFWEDLGAYIPLKGNKFCINCVTGPDEYTALVDNNAYTNYMAKMNLEYAYDIANKMKKEVPQKYQKVASKLNLKDEEIVAWKKAADNMYLPYSKELDIIPQDDSFLYKERITVDEIPEDQFPLLLHWHYLNIYRYQICKQPDVLLLMFLQREKFTKDELKKNYDYYEPITTHDSSLSPAIFSILANEIGYTDKAYKYFMMTARMDLDDYNDNVKDGIHAASMAGTWSAVVNGFGGMRVYTNELHFEPRLPKEWNLLSFNVRYKGRKINVKLTKENVVFALLEGEPIEIYYFDKKILLEKGEIK
Protein: Putative acyl-[acyl-carrier-protein] desaturase DesA1 (Putative acyl-ACP desaturase DesA1) (EC 1.14.19.-) (P9WNZ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May be a desaturase involved in mycobacterial fatty acid biosynthesis.
Subcellular location: Cell surface {ECO:0000305|PubMed:9199463}.
Interaction partners:
- Putative acyl-[acyl-carrier-protein] desaturase DesA2
- Probable tRNA-dihydrouridine synthase
- NADPH-dependent stearoyl-CoA 9-desaturase
- NADPH oxidoreductase
- Probable fatty acid synthase Fas
- Ferredoxin
- Protein NrdI
- Ribonucleoside-diphosphate reductase subunit alpha
- Vitamin B12-dependent ribonucleoside-diphosphate reductase
- Conserved protein
Sequence:
MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
Protein: Ceramide kinase-like isoform 9 (G0XYF7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFRGRRRSRVGALEEAPPENPKAAAEPERVLLRGIFEIRRESCDVALGERALRWRRIQPELPAGGTRHDLLSKEESLELEDIFSVKLKRRCWAKHPGRDTLLGITLFICLKEQRNKLKDSTLDLINFSEDHCDIWFRQFKKILDGFTSRPKALKILLNPQSHRKESVHVYYEKVEPLLKLAGIETDVTITEYEGHALSLLDECELRGFDGVVCVGGDGSASEAARALLLRAQKNAGVEMDCIPTLVGAELPLGFIPAGKA
Protein: Alpha-defensin-related sequence 2 (CRS4C1) (Cryptdin-related protein 4C-1) (Defensin-related cryptdin-related sequence 2) (P17534)
Organism: Mus musculus (Mouse)
Function: Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MKKLVLLFALVLLAFQVQADSIQNTDEETKTEEQPGEKDQAVSVSFGDPQGSALQDAALGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK
Protein: Probable galacturonosyltransferase 3 (EC 2.4.1.-) (Q0WQD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in pectin and/or xylans biosynthesis in cell walls.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Alkaline-phosphatase-like family protein
- Protein trichome birefringence-like 6
- Granule-bound starch synthase 1, chloroplastic/amyloplastic
- Protein trichome birefringence-like 19
- Protein trichome birefringence-like 38
- Protein ECERIFERUM 26-like
Sequence:
MTTFSTCAAFLSLVVVLHAVHVGGAILESQAPHRELKAYRPLQDNNLQEVYASSAAAVHYDPDLKDVNIVATYSDHYGNIRLGRVKMGDLSPSWVLENPAYQVSRKTKGSQLVIPRDSFQNDTGMEDNASHSTTNQTDESENQFPNVDFASPAKLKRQILRQERRGQRTLELIRQEKETDEQMQEAAIQKSMSFENSVIGKYSIWRRDYESPNADAILKLMRDQIIMAKAYANIAKSKNVTNLYVFLMQQCGENKRVIGKATSDADLPSSALDQAKAMGHALSLAKDELYDCHELAKKFRAILQSTERKVDGLKKKGTFLIQLAAKTFPKPLHCLSLQLAADYFILGFNEEDAVKEDVSQKKLEDPSLYHYAIFSDNVLATSVVVNSTVLNAKEPQRHVFHIVTDKLNFGAMKMWFRINAPADATIQVENINDFKWLNSSYCSVLRQLESARLKEYYFKANHPSSISAGADNLKYRNPKYLSMLNHLRFYLPEVYPKLEKILFLDDDIVVQKDLAPLWEIDMQGKVNGAVETCKESFHRFDKYLNFSNPKISENFDAGACGWAFGMNMFDLKEWRKRNITGIYHYWQDLNEDRTLWKLGSLPPGLITFYNLTYAMDRSWHVLGLGYDPALNQTAIENAAVVHYNGNYKPWLGLAFAKYKPYWSKYVEYDNPYLRRCDINE
Protein: Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) (Q99966)
Organism: Homo sapiens (Human)
Function: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:16864582}. Cytoplasm {ECO:0000269|PubMed:16864582}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
Interaction partners:
- Histone acetyltransferase p300
- CREB-binding protein
- Homeobox protein SIX2
- Mothers against decapentaplegic homolog 4
- Transcription factor AP-2-alpha
- Estrogen receptor
Sequence:
MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC
Protein: RING-H2 finger protein ATL56 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ATL56) (Q9ZV51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable E3 ubiquitin-protein ligase ARI9
- Probable E3 ubiquitin-protein ligase ARI5
- Probable E3 ubiquitin-protein ligase ARI7
- E3 ubiquitin-protein ligase UPL4
- Interferon-related developmental regulator family protein / IFRD protein family
- Cyclic nucleotide-gated ion channel 17
- E3 ubiquitin-protein ligase RHA2B
- Chloride channel protein CLC-c
Sequence:
MPPTNNYRISGEPPSTTPSHPPPKPKTRILSLFLVGVIMFSIFFLFLVLIGIASVLILPLLLSSLHRHHRRRRRNRRQESSDGLSSRFVKKLPQFKFSEPSTYTRYESDCVVCFDGFRQGQWCRNLPGCGHVFHRKCVDTWLLKASTCPICRARVRLWEEDPQEGELWRCFGHRRSSLLDL
Protein: Glycosyl transferase (A0A0H2UMY4)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKEDIEILFINAMSTDGTTAIIQQFIKEDTEFNSIRLYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTETFVMNNVAIIQQGEFVCGGPRPTIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREYGYKIRYSPSILSYQYIRPTFKKMLHQKYSNGLWIGLTSHVQFKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGFLIVMPFILFSIHFAYGLGTIVGLIRGFKWKKEYKRTIIYLDKISQINQNML
Protein: Beaten path Vc (MIP11332p) (Q9VG28)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Sidestep VI, isoform B
Sequence:
MSLLRLLGALLLATFNGMAPVPAEGLHLSNLSVPRIIDVAQKAKLFCSYAMGNRTLNSVKWYKDGLEFFRYSPLTPPTTNWFPVKGVTIADGSPHCNQFICNVELEKLTAHSSGQYRCEVSGDAPEFKLIDQTANMTVGVLPKFDPFISGVRHAYKYHDYLEANCSTEMSSPMAKLTWYINNKTAPGHSLQPQINEVSRNVDGFHLFASHLHLRLHLDDQRFISKSEMLELRCTADIMGLAAVRRESRVRTTILALRDAGTKQRLTENGSCMTGQPASLAAWLLSLVHILRWHSTQS
Protein: Uncharacterized protein (Q580S1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Cytoplasmic dynein 2 light intermediate chain 1
- Cytoplasmic dynein 2 heavy chain 1
- Intraflagellar transport protein IFT88, putative
- Cytoplasmic dynein 2 heavy chain 1
- Dynein heavy chain, putative
- Intraflagellar transport protein A1
- C2H2-type domain-containing protein
- Intraflagellar transport protein 57/55
- Intraflagellar transport protein 80
- Uncharacterized protein
Sequence:
MPIPCNFKDQITGEVHIPSTSRANVTYKQCECQTGVLKMQDMETQTAISALQAVNRSDKQVGHEKPQIQANIDGLQYVYAGVNYSEEALADFLEAAREDVLAILYRNVKNSAFDNYEPNWTKKSTELSAVATFRASYAEERDLHALSVSFNSSGTLLAVAYGQVDTAGWCNDTGMVGIWNLSRNDVNVNEPHHMMETDSFVTCVAFHPSQATVLAVGLYSGEVVLYKNVTDATPIEMTADGSSTSHREPVTFLQWTENLQETRDSHRYTLCSAGQDGRILFWTMGNKMAQPTAAFIIKTRKGATVGVQSACFSRPGGSAGRITPSSDSVLVIGLENGDVGRARPGVLAALPTRAGESEVSLELDWLSSHRGPVQCVDTSPFFHNLCLTCSSDGSARLYNMLETAAVATLEPSAESKHFLYAARFSPFRPSVIAVVSRSSFLHIYDLQKSQLKPVVTLEAGTDGAALMCVTFNHASPDWICTGDVSGSVRLWKLPSSLMQTTDLERAAVRDSRGRGGNAEDSEKNAVISLFGFSL
Protein: Enoyl-[acyl-carrier-protein] reductase [NADH] 1 (ENR 1) (EC 1.3.1.9) (Trans-2-enoyl-CoA reductase [NADH]) (TER) (EC 1.3.1.44) (Q9KRA3)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the NADH-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It can use both crotonyl-CoA and crotonyl-ACP.
Interaction partners:
- Fatty acid oxidation complex subunit alpha
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Fatty acid oxidation complex subunit alpha
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Aldehyde-alcohol dehydrogenase
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
Sequence:
MIIKPKIRGFICTTTHPVGCEANVKEQIAYTKAQGPIKNAPKRVLVVGSSSGYGLSSRIAAAFGGGAATIGVFFEKPGTDKKPGTAGFYNAAAFDKLAHEAGLYAKSLNGDAFSNEAKQKAIELIKQDLGQIDLVVYSLASPVRKMPDTGELVRSALKPIGETYTSTAVDTNKDVIIEASVEPATEQEIADTVTVMGGQDWELWIQALEEAGVLAEGCKTVAYSYIGTELTWPIYWDGALGRAKMDLDRAATALNEKLAAKGGTANVAVLKSVVTQASSAIPVMPLYIAMVFKKMREQGVHEGCMEQIYRMFSQRLYKEDGSAPEVDDHNRLRLDDWELRDDIQQHCRDLWPQITTENLRELTDYDMYKEEFIKLFGFGIEGIDYDADVNPEVEFDVIDIE
Protein: Candida glabrata strain CBS138 chromosome L complete sequence (Q6FKZ0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MSKFAVLIAAIAATLVNAQNAVEVAEIQVLVNDINSNLAQYLSLETNPDSGFQIPDNLLSLYRNVATYTDDSFSTLLSGVNFDEITSTIVGLPWYSSRLLPALESASSAAAGSGDAAAAPASANASSVSAAVTSLSSAINSTSSASASATGAVVTSANLTSVSANSTRSGSRSATRSASATGGVAGGNRTNGSTNGTKTSSTKSKNGVAKVEAGLAGALLAGAAAMLL
Protein: Novel proteinn (Ortholog of human cytokine induced protein 29 kDa CIP29) (SAP domain-containing ribonucleoprotein) (Q28HK0)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Interaction partners:
Sequence:
MAETVELHKLKLAELKQECLARGLEVKGNKSDLISRLQAYIEEHAEEEANEEDVLGEETEEEEQKSSVAAVKEEEPDDKPADTNAEKKLVKISSSASETDKLQKRAERFNVPASVDSKKAARAIRFGLSTSDKKGEISDAKSPVSMDKLKERAQRFGLSVSPVSKKSEDDEKLKKRKERFGIVTSSASVTDDTEAKKRKRAERFGIV
Protein: Hypoxia inducible factor 1 subunit alpha, like isoform X1 (Hypoxia-inducible factor 1 subunit alpha,-like) (A0A0R4IB28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPSLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSGSTKSQTEKSETPTDGFYQQALAGFILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGPIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVGETLPSLT
Protein: Probable plastid-lipid-associated protein 10, chloroplastic (Fibrillin-8) (Q8W4F1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16461379, ECO:0000269|PubMed:22274653}.
Interaction partners:
- Probable plastid-lipid-associated protein 13, chloroplastic
- Probable plastid-lipid-associated protein 8, chloroplastic
- Probable plastid-lipid-associated protein 9, chloroplastic
- Ribosome biogenesis protein BOP1 homolog
- DEAD-box ATP-dependent RNA helicase 51
- At1g72640
- Plastid-lipid-associated protein 6, chloroplastic
- Fibrillin-5, chloroplastic
- Probable plastid-lipid-associated protein 1, chloroplastic
- Glutaredoxin-C6
Sequence:
MDRIASATFSCPAISLSRVCRISPFGLNIKTNHRKRFSCRVAVASGETSARVVVDNELDLEHKKHDLLRAVQDTQRGLTATSDQRSIIEEALVTVEGFNGGEEIDPVKLDGTWRLQYTSAPDVVVLFEAASRLPFFQVGQVFQKFECRDRSDGGIIRNVVQWSLPSLLEEQEGATLVVTAKFDKVSSRNIYLQFEEISVRNININEQLQALIAPAILPRSFLSLQLLQFIRTFKAQIPVNATSPGRRSVGGLYYLSYLDNNMLLGRSVGGGGVFVFTKSQPLEL
Protein: Uncharacterized protein DKFZp451E186 (Q86T42)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPEPTKKEENDVPAPAPPPEEPSKEKEAGTTPAKDEEEVSPPSALPPGLGSRALERKDSDWTLVETPPGEEQAKQNANSQLSILFIEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPRPHWCSRFRWLCARVLL
Protein: Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) (O14950)
Organism: Homo sapiens (Human)
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Interaction partners:
- Myosin-9
- Myosin light polypeptide 6
- Myosin-10
- Myosin light chain 1/3, skeletal muscle isoform
- Protein phosphatase 1 regulatory subunit 12A
- Myosin light chain 6B
- Myosin-11
- Myosin light chain kinase 3
- Actin, cytoplasmic 1
- Myosin regulatory light polypeptide 9
Sequence:
MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
Protein: BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis protein) (APache) (D4A0X3)
Organism: Rattus norvegicus (Rat)
Function: Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:29262337}. Presynapse {ECO:0000269|PubMed:29262337}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:29262337}. Note=In primary cultures, mainly present at axonal and presynaptic terminal levels of mature neurons. In immature neurons, localizes to the cell body and growing processes, including axons. {ECO:0000250|UniProtKB:Q80TK0}.
Interaction partners:
- BTB domain containing 8
- AP2-associated protein kinase 1
- Epsin-2
- Adaptor related protein complex 3 subunit sigma 1
- AP complex subunit sigma
- Cation-independent mannose-6-phosphate receptor
- SH3-containing GRB2-like protein 3-interacting protein 1
- AP-2 complex subunit alpha
- Leucine-rich repeat neuronal protein 3
- AP-2 complex subunit beta
Sequence:
MAHCGAGGAAPAGLPRSPGLGRKGLPRKGSGERRRLKAVVSEQLSRDVLRLLREEMHTDMVLSVSGSLFKVHRAVLLARAPGFHSHITGHTSRGLTDELIPVDSVEASEFKAFLQIVYSSNKSVKNYEEEILQKMQVGNVMPEKGLDVSFLQCRTSSDCFLGKHEIPADVTSGGDSFISKDDCDLEPVSELGADLLKLYLSQDYHDIDICVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQECITLQGITHVEMSVMMHFIYGGTLDFPEKANVGQILNVADMYGLEGLREVAIYVLRRDYCNFFQKPVPRTWASILECLVIAHSVGVESLFADCMNCIISHFARFWSERSFANVPPEIQKTCLSMQIQSLNHGNAALLLMESDKLITGLPRVKWTEAALSMASQLQGECVTFIVQNFSQVMESASFTLLLQSQAMSSTAHLLDKIFKAIEDSITAENSCSLLMALDTLLKSDSAEEMGFTCRIQAVRDKLWTFLVQSFYAVRHTESWKLMHIDDQQKIQAAALDKGDDRRLGRKPVLSSSQQRRQGSDVIKIKPWTGNNKKLCRASPSTNEKMRSDGLGASGHASGTHRNSVNKVSKHGEGTKVSKVTTEVKTGATHVPGKPKTTIKPQTENNAHTKLESISSTVVGRPARMAATGRKDLAHGKGIQNQEGETTGARPKVLTANLNTQARAKPLQTVKGKDNGCSATVGPSSRSANSSMERLASTGSVDETKENGSVEDKSCDKKPYVSASPGQMVYNGVTSTVAVKSRPVSRVTSGTSSKKSFIHEQGPSVTSSVIKKGRGSSKGLNDSAPQTAAKRGGSSNGYAAAQPRTKSAPPTLAQTQGSQGESPHSVKSSISSRQSDESVTRLRHGTDKQMPKRKVVKQGHATLQKVNAKPTPKNPSQSTKGGTMTSKDSKQKVLPGQVTLQSQASQRPSNPEAATTQRSVLHGVNDNRSQVFKQRPPESLVNLASDTNGPEASPSPCRPQPQSPLGNQEKTRQEREHQDGSTLGDSVKHELRSELTSIEQSHTPAYKVSSQCSANPNCGCIASLKPVTSNPSENWINSNTANTDQVCVSDRERQTGRKGTDREPSVNCVARKAALPSVPAGMSGTLKSAQDDRKLPFHREELSAQGHLPHDCATEDSKCATPTSAVSSRCLLGQPSEKGYKNMEASGTSESHEAPEAPFMGPWDLNTSATHQRESPESDTGSATTSSDDIKPRSEDYDAGGSQDDEGSHDRGVSKCSTALCHDFLGRSSSDTSTPEELKVHEGDLRTEVRVRKPGGGDLPLHSASDDETPRKKPDPWSRSTIVHPREKGSAPRGSVPSAQEVDQVSSSADETEDERSEAENVREHSSPSNSGTQHVQGIINLAFEDGTEHESREFSATKKFRRSVLLSVDECEEVGSDEGEGHTPLQPSLDSLSPSDVFDGVSYEHHGRTGYSRFFKENEATTAEHKYSRGNDGHKNEGFLLSPRSRDFPRQGKQCVSTGEKTRLDVPPKASQQPFPESKDMTSKREVAHGLQQHGTLTDGDTRSQERPCHLELHQREPSSTIPKISSARSLDSCPSQVLPQDGQVTATHPTPPKRANNAVFSGDIDDCDTMAQTTMYDHRPSKTLSPIHEMSLTAACEQKEESGTHVADRASEDEQPFAKQDWTLLKQLLSEQDANLNVTSSLPEDLSLAQYLINQTLLLARDSSKPQGSAHADTWNRWSELSSPLDDLTASATTVSVSSTDCSPQGEWTILELETQH
Protein: WRKY transcription factor 44 (Protein TRANSPARENT TESTA GLABRA 2) (WRKY DNA-binding protein 44) (Q9ZUU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Regulates trichome development, production of mucilage and tannin in seed coats, and maybe root hair development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SI37}.
Interaction partners:
- Protein TRANSPARENT TESTA GLABRA 1
- Transcription factor TT8
- Homeobox-leucine zipper protein GLABRA 2
- Transcription factor TT2
- Protein TRANSPARENT TESTA 1
- Protein TRANSPARENT TESTA 16
- Transcription factor EGL1
- Transcription factor GLABRA 3
- Dihydroflavonol 4-reductase
- Glutathione S-transferase F12
Sequence:
MEVNDGERVVIAKPVASRPSSSSGFRTFTELLTDSVTVSPQTTCHEIVDAAIRPKTLRFNQPVAASVSCPRAEVKGIGNGMSCDDDSDSRNYVVYKPKAKLVSKATVSALANMLQGNRQQTWRQSEAVSYGKSVSQGTHRAGPNLVQKVPSFTESETSTGDRSSVDGYNWRKYGQKQVKGSECPRSYYKCTHPKCPVKKKVERSVEGQVSEIVYQGEHNHSKPSCPLPRRASSSISSGFQKPPKSIASEGSMGQDPNNNLYSPLWNNQSNDSTQNRTEKMSEGCVITPFEFAVPRSTNSNPGTSDSGCKSSQCDEGELDDPSRSKRRKNEKQSSEAGVSQGSVESDSLEDGFRWRKYGQKVVGGNAYPRSYYRCTSANCRARKHVERASDDPRAFITTYEGKHNHHLLLSPPSSSTLPFNSPQLSKQTI
Protein: Lrrk2 protein (B4F7C3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
DITVECIAATNLNSKRATLWLGCGNTEKGQLSLLDLNTERYSYEEVTDSRILCLALVHLAAEKESWVVCGTQSGALLVINAEDETRRHTLDKMTDSVTCLYCNSFAKQSKQSHFLLVGTADGNLMIFEDKTIKCKGAAPLKTLHIGDVSTPLMCLSESMNSSERHITWGGCGTKIFSFSNDFTIQKLIETRTNQLFSYSAFSDSNIIAVAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKINKDSKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMATAQLGSLKNVMLVLGYKRKSTEGTQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADKMRKTSVE
Protein: Calcium-binding protein CML42 (Calmodulin-like protein 42) (Q9SVG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable calcium sensor that binds calcium in vitro. Involved in the regulation of trichome branching.
Interaction partners:
- Probable calcium-binding protein CML14
- Calcium-binding protein CP1
- Calcium-binding protein KIC
- Probable calcium-binding protein CML34
- Probable calcium-binding protein CML49
- Chromo domain cec-like protein
- Probable calcium-binding protein CML48
- Probable calcium-binding protein CML13
Sequence:
MESNNNEKKKVARQSSSFRLRSPSLNALRLQRIFDLFDKNGDGFITVEELSQALTRLGLNADLSDLKSTVESYIQPGNTGLNFDDFSSLHKTLDDSFFGGACGGGENEDDPSSAAENESDLAEAFKVFDENGDGFISARELQTVLKKLGLPEGGEMERVEKMIVSVDRNQDGRVDFFEFKNMMRTVVIPSS
Protein: Gustatory receptor 8a (Q9W367)
Organism: Drosophila melanogaster (Fruit fly)
Function: Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing and avoiding L-canavanine, a plant-derived insecticide.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Putative gustatory receptor 98b
- Gustatory receptor for bitter taste 66a
- Uncharacterized protein
- Gustatory and pheromone receptor 33a
- Gustatory receptor for bitter taste 93a
- Gustatory receptor
- Putative gustatory receptor 59c
- Gustatory and pheromone receptor 32a
Sequence:
MSGHLGRVLQFHLRLYQVLGFHGLPLPGDGNPARTRRRLMAWSLFLLISLSALVLACLFSGEEFLYRGDMFGCANDALKYVFAELGVLAIYLETLSSQRHLANFWWLHFKLGGQKTGLVSLRSEFQQFCRYLIFLYAMMAAEVAIHLGLWQFQALTQHMLLFWSTYEPLVWLTYLRNLQFVLHLELLREQLTGLEREMGLLAEYSRFASETGRSFPGFESFLRRRLVQKQRIYSHVYDMLKCFQGAFNFSILAVLLTINIRIAVDCYFMYYSIYNNVINNDYYLIVPALLEIPAFIYASQSCMVVVPRIAHQLHNIVTDSGCCSCPDLSLQIQNFSLQLLHQPIRIDCLGLTILDCSLLTRMACSVGTYMIYSIQFIPKFSNTYM
Protein: Bromodomain containing 8 (E9PTN1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- Histone acetyltransferase KAT5
- Inhibitor of growth protein 3
- E1A-binding protein p400
- MRG domain binding protein
- Vacuolar protein sorting-associated protein 72 homolog
- Chromatin modification-related protein MEAF6
- YEATS domain containing 4
- RuvB-like helicase
- Enhancer of polycomb homolog
Sequence:
MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCSDIAMKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMPVPSGHLSSTGVLLEVGGVLPMIHGGDIQPATSAVAASPAASGAPTLSRLLEAGPTQFSTPLPSFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTPESVAPVSQPEPCVPLEAVGDPQTVTVSMDSSEISMIINSIKEECFRSGVAEAPGGSKAPSIDGKEDLDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEESETKGIHELVDIRDSGVEIKVEPTEPEPGMSGAEIVAGVGPVPSLEPPELRSQDLDEEPRSSAAGEMGEADGSSGKGEERPLPAVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEEEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLGDSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDGGTRGRRCAIEADMKMKK