wanglab/gogpt-training-data huggingface dataset:
Protein: Non-neuronal cytoplasmic intermediate filament protein B (IFB) (P16275)
Organism: Helix pomatia (Roman snail) (Edible snail)
Function: Epithelial intermediate filament protein.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
TSKISTTYEEEGRQSKIQPRAFVITRSGPTSRSSSYSARQSYGSRSSITPGVYQQLSSSGITDFRGTREKEKREMQNLNERLAGYIEKVHFLDAQVKKLEAENEALRNRKSESLQPIRDAYENELAQARKVIDELSSTKGVSEAKVAGLQDEIASLRELIGTYENQSKDYRKKIESLGNQIGEYEGELHTLRIRCGSLEDENAKVRELLDKIQDQNRRLRADLDTETSAHIEADCLAQTKTEECEFYKDLLDQLELLKPEPMQIKGMDYAEFWKSELSKCVRDIQSAYDEKIDIIQQDIEAKYSSQINSLRSGNVKDGMQLQHVQEEVKKLRTQAGEKNAAYAELAAKFASLQAERDAIGRQCSELERELEELRIKYNQDIGDLSNELSAVLAQLQTLTDVKITMELEIACYRKLLEGEESRVGLRSLVEQAIGVQGRGTASLKDTIQQS
Protein: Uncharacterized protein (Q382I3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFSRTEVDALFNEALRVSQRSLLLLNERSRGPPPPQQQHLQSSSTVGSSGFATTVQELRNLADFSAFVDAAGDVCQRIQKESRQPSSTMQRRRQNGATYPLLSRVVEGLVGVRRVWNGGVEELWSSGAALTLLLLRAALFADWVHGMAKAEEIRTTLCGVTENASAFPLREQLRREVDPLLLLLRKVREGMPEEFVDQFDAEVIRVMCRLPMSVNAGREHAIAPLYSLLLFPGLIPYVALNAAHPLAAMNVVAPIESIATGLLQVYLRESAVEFSRACSTLVRHAVLVGACVEQGATLVGEIQKGVCFMKQLFDALLVSVERAFSAAAAPRAGMTEVFCSAFAGPFRALVQMWVSTGRDASPVVPANELRTLSHVWCTASYRALIVVESLGHAELGVLSGCGSATSQQKRYNAMLQQSRGKITTAILSAVTEDRLLLFEETAARSGHGHKVFRICDAGVAPASGSGNPCVFVYIDNGTVYMKVGRERTFRRANSVEEVFSIFTQ
Protein: Regulator of the glycerol channel 1 (Q06108)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulator of FPS1 glycerol channel required for the glycerol efflux.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15023338}.
Interaction partners:
- Glycerol uptake/efflux facilitator protein
- Mitogen-activated protein kinase HOG1
- Activator of SKN7 protein 10
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL22m
Sequence:
MSDYFTFPKQENGGISKQPATPGSTRSSSRNLELPKNYRSFGGSSDELASMYSADSQYLMDMIPDSLTLKNEPASGNTQMNGPDGKENKDIKLDEYILPKTDPRSPYYINMPIPKKLPKSEGKARAKQKVNRADPSDLDVENIYETSGEFVREYPTDILIDRFHKWKKILKSLIAYFREAAYSQEQIARINYQMKNAVKFAFLTDLEDETNKLVDPSISKLPTKKPQPVPLAAQKLDSKYDTDVEQPQSIQSVPSEEVASASSGFMKFGSGSIQDIQVILKKYHLSLGSQQYKISKEILAYIIPKLTDLRKDLTTKMKEIKELNGDFKTNIGEHIKITSRLLNKYIASVKLLDEASTSGDKQGEKLKPKHDPYLLKLQLDLQLKRQLLEENYLREAFLNLQSAALQLEKIVYSKIQSALQRYSALIDSEARLMIKNLCHELQQGILSRPPAVEWDNFVSHHPTCLMNLKSTDPPPQPRRLSDIVYPNMKSPLAKCIRVGYLLKKTESSKSFTKGYFVLTTNYLHEFKSSDFFLDSKSPRSKNKPVVEQSDISRVNKDGTNAGSHPSSKGTQDPKLTKRRKGLSSSNLYPISSLSLNDCSLKDSTDSTFVLQGYASYHSPEDTCTKESSTTSDLACPTKTLASNKGKHQRTPSALSMVSVPKFLKSSSVPKEQKKAKEEANINKKSICEKRVEWTFKIFSASLEPTPEESKNFKKWVQDIKALTSFNSTQERSNFIEEKILKSRNHNNGKSSQRSKNSTYITPVDSFVNLSEKVTPSSSVTTLNTRKRANRPRYIDIPKSANMNAGAMNSVYRSKVNTPAIDENGNLAIVGETKNSAPQNGMSYTIRTPCKSPYSPYTGEGMLYNRSADNLMASSSRKASAPGEVPQIAVSNHGDEAIIPASAYSDSSHKSSRASSVASIHNQRVDFYPSPLMNLPGVSPSCLALDGNANGYFGIPLNCNSEARRGSDLSPFEMESPLFEENRTQNCSGSRKSSACHIPHQCGPRKEGNDSRLIYGNEKGASQSRLTLKEPLTSKGVEAPYSSLKKTYSAENVPLTSTVSNDKSLHSRKEGSTNTVPATSASSK
Protein: Plant intracellular Ras-group-related LRR protein 2 (Q9LRV8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Interaction partners:
- F-box protein At3g17710
- Immune-associated nucleotide-binding protein 4
- Putative cysteine-rich receptor-like protein kinase 31
- Flotillin-like protein 1
- Cysteine-rich receptor-like protein kinase 41
- At2g19340
- Serine/threonine-protein phosphatase PP1 isozyme 8
- Zinc finger CCCH domain-containing protein 26
- Protein ROH1A
- Ubiquitin-fold modifier 1
Sequence:
MDHDLDKFPLLSYVLHQHDSNLHAPPSMAAQETLLPSFPLLSNPEIMSMLTQSIPTTITQTLFVFNSLGSRPDPLAVSSARFKIAQIMDSLSPEEAAKESEIYAGVVRLDEVHDSYEKKLKDTEEELSRVYSTEVESMLRSGEEVNEKVLAVLKEAESGGTVERIDLSSQELKLIPEAFWKVVGLVYLNLSGNDLTFIPDAISKLKKLEELDVSSNSLESLPDSIGMLLNLRILNVNANNLTALPESIAHCRSLVELDASYNNLTSLPTNIGYGLQNLERLSIQLNKLRYFPGSISEMYNLKYLDAHMNEIHGIPNSIGRLTKLEVLNLSSNFNNLMGVPDTITDLTNLRELDLSNNQIQAIPDSFYRLRKLEKLNLDQNPLEIPSQEVATQGAEVVREFMRKRWGDIMAEQQQRIGVEAERHGDENGWVYWGTSMVTNLVSGVTHTIGFGGATSDGGDKKPGDSYFYHQI
Protein: Replication enhancer (REn) (16.1 kDa protein) (Protein C3) (Protein L3) (P14994)
Organism: Beet curly top virus (strain California/Logan) (BCTV)
Function: Increases viral DNA accumulation. Enhances infectivity and symptom expression (By similarity).
Interaction partners:
Sequence:
MNVIEDFRTGEPITLHQATNSVEFESVPNPLYMKLLWFERYGPIYQLKIQIRFNYNLRRALNLHKCWIELTITGSNRILTGPRFLKVLKKRLEIYLDNLGLICINNVIRGLNHVLYEEFNFVSSVIQNQSVAMNLY
Protein: Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)] (P39060)
Organism: Homo sapiens (Human)
Function: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061}.; SUBCELLULAR LOCATION: [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061}. Secreted {ECO:0000250|UniProtKB:P39061}.; SUBCELLULAR LOCATION: [Endostatin]: Secreted {ECO:0000269|PubMed:10441114}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000305}.
Interaction partners:
- Glypican-1
- Nucleolin
- 72 kDa type IV collagenase
- Vascular endothelial growth factor receptor 2
- Protein Dr1
- Matrix metalloproteinase-9
- Collagen alpha-1
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Plasminogen
- Thrombospondin-1
Sequence:
MAPYPCGCHILLLLFCCLAAARANLLNLNWLWFNNEDTSHAATTIPEPQGPLPVQPTADTTTHVTPRNGSTEPATAPGSPEPPSELLEDGQDTPTSAESPDAPEENIAGVGAEILNVAKGIRSFVQLWNDTVPTESLARAETLVLETPVGPLALAGPSSTPQENGTTLWPSRGIPSSPGAHTTEAGTLPAPTPSPPSLGRPWAPLTGPSVPPPSSGRASLSSLLGGAPPWGSLQDPDSQGLSPAAAAPSQQLQRPDVRLRTPLLHPLVMGSLGKHAAPSAFSSGLPGALSQVAVTTLTRDSGAWVSHVANSVGPGLANNSALLGADPEAPAGRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSVPPPAPPPCCQFCEALQDACWSRLGGGRLPVACASLPTQEDGYCVLIGPAAERISEEVGLLQLLGDPPPQQVTQTDDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQAMVLLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVDCEEFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDEEGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEVEEQTTVASLGAQTLPGSDSVSTWDGSVRTPGGRVKEGGLKGQKGEPGVPGPPGRAGPPGSPCLPGPPGLPCPVSPLGPAGPALQTVPGPQGPPGPPGRDGTPGRDGEPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDLEALRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGPPGREGPPGRTGQKGSLGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVPGFPGLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQPGLPGPPGPPGPVVYVSEQDGSVLSVPGPEGRPGFAGFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGPPGTPVYDSNVFAESSRPGPPGLPGNQGPPGPKGAKGEVGPPGPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPGGGGFFGSSLPGPPGPPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPGPPGPPGPPGPPGTMGASSGVRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPEPQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHAYIVLCIENSFMTASK
Protein: Aminopeptidase (EC 3.4.11.-) (Q22317)
Organism: Caenorhabditis elegans
Interaction partners:
- Gamma-glutamyltranspeptidase 1
- Gamma-glutamyltranspeptidase 1
- Gamma-glutamyltranspeptidase 1
- Gamma-glutamyltranspeptidase 1
- Glutamate--cysteine ligase
- GCS light chain
- Putative aminopeptidase W07G4.4
- Glutathione synthetase
- glutathione-specific gamma-glutamylcyclotransferase
- gamma-glutamylcyclotransferase
Sequence:
MASAYTYGSFPQMGHPPPKETKKGCQVKSFVLPVFCTLLGVLITAFITWHITKSQYSRNDPHDEIESENVPAAKPEDNISASELRLPTSVSPISYQLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDLNYTEEFIKKSSILVNGKSIAFTLDDKQSTHEKIFFNLDETVEPTTSATLKVAFGAPLRTDMSGLYQTTYTNSKGESKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSNGIEDKVEDGQPGFIISTFKPTPRMSSYLLAIFISEFEYNEATTKSGVRFRVWSRPEEKNSTMYAVEAGVKCLEYYEKYYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVAVVIAHELAHQWFGNLVTLKWWNDLWLNEGFATLVEYLGTDEISDGNMRMREWFTMDALWSALAADSVASTHPLTFKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYLTRHQFDNADAGNLLTALGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTHIIVEQSRFKLLATGKEEEKYSNPVWGFKWDVPVWYQVVGSSELEMKWMKRNEPLIIKSDKNVIINAESNGFYRAGYSSGLWKEISEMLKENHEQFSPQTRVRLIDDSFALARAGLLSYSIPLNLITYLKNEKEYLPWSGAIAKIRELIDMYGSNPEKDIVNKFMIALAENAPARRSIDFVSKNYLDEKKFYEVGAAQQIILNSCGFGDSVCQADMVKMFTEEVLAKCDATRILSECSQIPAPFRAESYCEAVRNGNSDTFEKVFHWYKTERNQVEKLNLMTALTCSKDILTLKKLLLDAMKPEGSSFRLQDCAALFAKISSNDATTDAMLNFLIDRWEDMQKRLATDHSGFSRVLSSIVNTLKTRGGLDQLRKFRKKAPKASEFGLDKMEESAEVTVTWRETNLKFVTKIIEEISKSL
Protein: Epidermal patterning factor-like protein (F4IMT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU367102}.
Interaction partners:
Sequence:
MGFERTSSSLSLLSSSLPSSLQPSENTRAKFSLFYLLLLFFVLCVIATFTITPTSTSSPYNRNSNSGTLGNFYAKVRKLFIPLTLLRDLTISDCDGMSRLTGHAEMPCTPKEILSRRIGFSAHEDKDSTQLLVRSPLVGPCLAYDLDRVEEGKSTVVIKKTRKIGDRSKEAELRRILRGLGSSPPRCSSKCGRCTPCKPVHVPVPPGTPVTAEYYPEAWRCKCGNKLYMP
Protein: Transient receptor potential channel (Abnormal gonad development protein 2) (Q93971)
Organism: Caenorhabditis elegans
Function: Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transient receptor ion channel domain-containing protein
- Ion transport domain-containing protein
- MFS domain-containing protein
- Nicotinic receptor-associated protein 1
- Inositol 1,4,5-trisphosphate receptor itr-1
- CUP-5L
- Ion transport domain-containing protein
- Stromal interaction molecule 1
- Ion transport domain-containing protein
Sequence:
MMSDDMLDENDENFACQDVDEIIIYVPEFAGYREVNIDTAVSVCPTPIQQARRESSCRNLEMRRRFEKLRREKKEEKKLLADDEKDFDEDDDVFEDGEGLQMRTFQPNASIRDENGSMPSLLPRTAPIKKTRKHRRRRSGSFTGGVYPRKGHRNRSLLGHAIPPPNVHSADWRDMLAITDNKDDKLMKTLGVTRYLQSKGGDQVPPTSTTTGGAGGDGNAVPTTSQAQAQTFNSGRQTTGMSSGDRLNEDVSATANSAQLVLPTPLFNQMRFTESNMSLNRHNWVRETFTRRECSRFIASSRDLHKCGCGRTRDAHRNIPELTSEFLRQKRSVAALEQQRSISNVNDDINTQNMYTKRGANEKWSLRKHTVSLATNAFGQVEFQGGPHPYKAQYVRVNFDTEPAYIMSLFEHVWQISPPRLIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHVAAALEGAQSAQRNKIVCIGIAPWGLLKKREDFIGQDKTVPYYPSSSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKRLEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLAFAHQNVTEDGLLPDDIRRQVLLLVETTFGCSEAAAHRLLHELTVCAQHKNLLTIFRLGEQGEHDVDHAILTALLKGQNLSAADQLALALAWNRVDIARSDVFAMGHEWPQAALHNAMMEALIHDRVDFVRLLLEQGINMQKFLTISRLDELYNTDKGPPNTLFYIVRDVVRVRQGYRFKLPDIGLVIEKLMGNSYQCSYTTSEFRDKYKQRMKRVKHAQKKAMGVFSSRPSRTGSGIASRQSTEGMGGVGGGSSVAGVFGNSFGNQDPPLDPHVNRSALSGSRALSNHILWRSAFRGNFPANPMRPPNLGDSRDCGSEFDEELSLTSASDGSQTEPDFRYPYSELMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLATEAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVNNKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPFIQMLEFKTREELLNQPQTAAEHQNDMNYSSSSSSSSSSSSSSSSSDSSSFEDDDDENNAHNHDQKRTRKTSQGSAQSLNITSLFHSRRRKAKKNEKCDRETDASACEAGNRQIQNGGLTAEYGTFGESNGVSPPPPYMRANSRSRYNNRSDMSKTSSVIFGSDPNLSKLQKSNITSTDRPNPMEQFQGTRKIKMRRRFYEFYSAPISTFWSWTISFILFITFFTYTLLVKTPPRPTVIEYILIAYVAAFGLEQVRKIIMSDAKPFYEKIRTYVCSFWNCVTILAIIFYIVGFFMRCFGSVAYGRVILACDSVLWTMKLLDYMSVHPKLGPYVTMAGKMIQNMSYIIVMLVVTLLSFGLARQSITYPDETWHWILVRNIFLKPYFMLYGEVYADEIDTCGDEAWDQHLENGGPVILGNGTTGLSCVPGYWIPPLLMTFFLLIANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQVMEYESTPFLPPPLTPLYHGVLILQFVRTRLSCSKSQERNPMFDFSLKLFLDNDQIEKLHDFEEDCMEDLARQKLNEKNTSNEQRILRADIRTDQILNRLIDLQAKESMGRDVINDVESRLASVEKAQNEILECVRALLNQNNAPTAIGRCFSPSPDPLVETANGTPGPLLLKLPGTDPILEEKDHDSGENSNSLPPGRIRRNRTATICGGYVSEERNMMLLSPKPSDVSGIPQQRLMSVTSMDPLPLPLAKLSTMSIRRRHEEYTSITDSIAIRHPERRIRNNRSNSSEHDESAVDSEGGGNVTSSPRKRSTRDLRMTPSSQVEESTSRDQIFEIDHPEHEEDEAQADCELTDVITEEEDEEEDDEEDDSHERHHIHPRRKSSRQNRQPSHTLETDLSEGEEVDPLDVLKMKELPIIHQILNEEEQAGAPHSTPVIASPSSSRADLTSQKCSDV
Protein: Inner membrane metabolite transport protein YhjE (P37643)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized transporter YeaV
Sequence:
MQATATTLDHEQEYTPINSRNKVLVASLIGTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRVTVLGTFIMLATYTLFYIMTVYSMTFSTAAAPVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYGLGAVGLYLAAMAGLTLIALLLTHETRHQSL
Protein: Phosphoethanolamine N-methyltransferase (PfPMT) (EC 2.1.1.103) (Q8IDQ9)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16704982, ECO:0000269|PubMed:24145416}; Peripheral membrane protein {ECO:0000269|PubMed:16704982}. Cytoplasm {ECO:0000269|PubMed:24145416}.
Interaction partners:
- ethanolamine kinase
- choline-phosphate cytidylyltransferase
- Choline kinase
- ethanolamine-phosphate cytidylyltransferase
- Small ribosomal subunit protein eS30
- protein-synthesizing GTPase
- Multifunctional methyltransferase subunit TRM112, putative
Sequence:
MTLIENLNSDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN
Protein: Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region) (P0DOY2)
Organism: Homo sapiens (Human)
Function: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
Sequence:
GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Protein: Glucose 1-dehydrogenase 4 (EC 1.1.1.47) (GLCDH-IV) (P39485)
Organism: Priestia megaterium (Bacillus megaterium)
Interaction partners:
Sequence:
MYTDLKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAIIVQGDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELSLDNWNKVIDTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAMNTPINAEKFADPVQRADVESMIPMGYIGKPEEVAAVAAFLASSQASYVTGITLFADGGMTKYPSFQAGRG
Protein: Sulfotransferase (EC 2.8.2.-) (Q1L874)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAQEECKMISDKLLKYKETVLTLEPSYDITPEYIDSIQDFETRDDDVFVVTFPKSGTVWTQRIITLIYEEDFPEKAKQITFEQMPWIEYRKKGKDYSTRPSPRLFCSHLLEPLMPKTLKRKGKVIYVMRNPKDVMVSYFHFSKKMKNLDSAKSYDEVLENFLTGCMVGGSWFDHVKGWVTSKDKYNILILTYEEMIKDLRSVIVKICEFVGKNLSDAAIDKVVERATFKQMKVDPVANYESLPVDITDQPKGAFMRKGTVGDWRNSLTMAQSECVDGALEERMKDVPLNLVWDITELRG
Protein: Niacin transporter NiaX (Niacin ECF transporter S component NiaX) (A2RKV5)
Organism: Lactococcus lactis subsp. cremoris (strain MG1363)
Function: Probably a niacin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins. Uptake of niacin into proteosomes containing EcfA1A2T and Niax has been demonstrated. Uptake requires hydrolyzable Mg-ATP and is substrate-specific; NiaX-containing proteosomes did not transport riboflavin.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21135102}; Multi-pass membrane protein {ECO:0000305|PubMed:21135102}.
Interaction partners:
- Thiamine transporter ThiT
- Riboflavin transporter RibU
- Queuosine precursor transporter QueT
- Manganese ABC transporter ATP binding protein
- Pantothenic acid transporter PanT
Sequence:
MRNHDCPTVRFFKARVYKEKETQMTQTKKAKVRNLIIAAMLTALGILIPMMMPVKLIIGPASFTLAAHVPVMAAMFFSPLMTAFVALGTTLGFMISIPVPTIWLRALMHLPVMTVGAYVLKKYPEFVHQKVKIQIFNFILGIFHAGLETLVVYAFYSLGFANIEQGALLNFLLLIALGGLVHSMIDFNLALGLGNVLSKAFPIDIFDKAKNLVNKKKVKAEI
Protein: Sec24c protein (Q3V222)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004397}.
Interaction partners:
Sequence:
PQPNYESPYPGAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCVNDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRAVLNSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTAEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRMRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDLLCHMHKEIRQLLS
Protein: Zinc finger protein 641 (F8VXJ5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQAEDRSQFGSAAEMLSEQTAALGTGWESMNVQLDGAEPQVERGSQEERPWRTVPGPLEHLCCDLEEEPQSLQEKAQSAPWVPAIPQEGNTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGE
Protein: Protein BZR1 homolog 1 (OsBZR1) (Protein BRASSINAZOLE-RESISTANT 1 homolog 1) (Q7XI96)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Positive brassinosteroid-signaling protein. Mediates downstream brassinosteroid-regulated growth response and feedback inhibition of brassinosteroid (BR) biosynthetic genes. May act as transcriptional repressor by binding the brassinosteroid-response element (BREE) (5'-CGTG(T/C)G-3') in the promoter of DLT (AC Q9LWU9), another positive regulator of BR signaling. Acts as transcriptional repressor of LIC, a negative regulator of BR signaling, by binding to the BRRE element of its promoter. BZR1 and LIC play opposite roles in BR signaling and regulation of leaf bending.
Subcellular location: Nucleus {ECO:0000269|PubMed:17699623, ECO:0000269|PubMed:30920691}. Cytoplasm {ECO:0000269|PubMed:17699623, ECO:0000269|PubMed:30920691}. Note=Brassinosteroid promotes nuclear localization, and binding to GF14C is required for cytoplasmic retention and efficient inhibition of BZR1 when brassinosteroid levels are low. {ECO:0000269|PubMed:17699623}.
Interaction partners:
- Shaggy-related protein kinase GSK2
- Shaggy-related protein kinase GSK1
- Shaggy-related protein kinase GSK4
Sequence:
MTSGAAAAGRTPTWKERENNKRRERRRRAIAAKIFTGLRALGNYNLPKHCDNNEVLKALCREAGWVVEDDGTTYRKGCKPPPSSAGGASVGMSPCSSTQLLSAPSSSFPSPVPSYHASPASSSFPSPSRIDNPSASCLLPFLRGLPNLPPLRVSSSAPVTPPLSSPTASRPPKIRKPDWDVDPFRHPFFAVSAPASPTRGRRLEHPDTIPECDESDVSTVDSGRWISFQMATTAPTSPTYNLVNPGASTSNSMEIEGTAGRGGAEFEFDKGRVTPWEGERIHEVAAEELELTLGVGAK
Protein: Tudor domain-containing protein 7 (E1C3S7)
Organism: Gallus gallus (Chicken)
Function: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.
Subcellular location: Cytoplasm {ECO:0000250}. Note=Localizes to cytoplasmic RNA granules. {ECO:0000250}.
Interaction partners:
- Piwi-like protein 1
- Tudor domain containing 9.
- Uncharacterized protein.
- Nanos C2HC-type zinc finger 1
- CS domain-containing protein.
- Beta-crystallin B3
Sequence:
MQEPDLVAKALRSVLHSSKHGIPLSELQDEYRSLTGEWIPFRHLGYATLEAYVASIPEVVRIERNQTGEVTCHAVACPETIYVRVWAVAHKRTSPIFLLFCCRQNIEKTLQMIRVLDICAIFKDPRWSSEVSFVVSVSVCLRRDQLSHHGFKRSCTFTCPEGLPLIQMVSFPIKSILSEKGLIPAYEKNHSNSEFYFSLTDNLNASGVETHTVASGRSVPNISEIQNRIKEILSKYRNGVWLSKIAQVYEETYREELSTTVLRQLEHWPHVCTVEKVRTGDQTYRILYPSKRIPPAVKSNTEQDQASQNVTSSKAGPVLKTSREAESASCSSDFKQNVVNILVKYPCGLWADALPKLYQDAYQRKFPEGILNNLQLLSDVCVVDYVSNVPQKAILYVKTQSCTDENLNVTEKVQIPDGAKATAEQQHEESKEQYPESISSVPPLVIPSEGPVSVLVIDVNNPNELIIRYVGKDYSGAQEQMEDKMKAYYSKNSTASQITFPSVGQLVAVHTEEEAWLRAQIISVEDKRLKLSCFCTYFGCITFRMCKPKENTHCCMKQCTSHKCKLTGLEVFSDDPLLLKAVELQAYHKICAVEILERSDIPVFVLYDTSGEDDININATCLKALYDKSFELNLQVDTLYTNVRVTSILSDGNMYCQLPSEGLSKLSEVLQKIEYYLLHQETSEFNVSQPYCGKICLFLCKGKWTRVEITIIHSRRALGVRFIDTGRVAYVKVTDLREIPSQFLREVIKIPPQAIKCCLADLPPDTGMWTPEAVLWLRDNVMDYAEFSMQVSVMEKRCVLKFWKAFIPISYLLADRSINRRINAVLWKHQKDVFLSVTSQGLAPPKHLNQGRLEKSDSLEPAVESRGVESATDVPPPLPLSEVGGFMDVYVSVACHPGHFIVQPWKEIHNLEALMEEMILYYSMAEERPVNIGTNKLYAAKIENRWYRVIVKGILRKGFLSVYVLDYGKHEVISIDKVQPLLDKFRKLPFQAIKAELAGVKSQQWSEEASIIFRNRVEKKPLVAQIQAINESTNSWDRKVVTYLVDTSIPDTDVWIHDFVCQSLAELSEAD
Protein: Protein odd-skipped-related 1 (B0K011)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGSKTLPAPVPIHPSLQLTNYSFLQAVNGLPTVPSDHLPNLYGFSALHAVHLHQWTLGYPAMHLPRSSFSKVPGAVSSLMDARFQLPAFPWFPHVIHPKPEITAGGSGAALKTKPRFDFANLALAATQEDPTKLGRGEGPGSPAGGLGALLDVTKLSPEKKPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHSQVKELKTSKIKC
Protein: Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5) (Q8IUH8)
Organism: Homo sapiens (Human)
Function: Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins. In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:30733281}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:16829952}.
Interaction partners:
Sequence:
MACLGFLLPVGFLLLISTVAGGKYGVAHVVSENWSKDYCILFSSDYITLPRDLHHAPLLPLYDGTKAPWCPGEDSPHQAQLRSPSQRPLRQTTAMVMRGNCSFHTKGWLAQGQGAHGLLIVSRVSDQQCSDTTLAPQDPRQPLADLTIPVAMLHYADMLDILSHTRGEAVVRVAMYAPPEPIIDYNMLVIFILAVGTVAAGGYWAGLTEANRLQRRRARRGGGSGGHHQLQEAAAAEGAQKEDNEDIPVDFTPAMTGVVVTLSCSLMLLLYFFYDHFVYVTIGIFGLGAGIGLYSCLSPLVCRLSLRQYQRPPHSLWASLPLPLLLLASLCATVIIFWVAYRNEDRWAWLLQDTLGISYCLFVLHRVRLPTLKNCSSFLLALLAFDVFFVFVTPFFTKTGESIMAQVALGPAESSSHERLPMVLKVPRLRVSALTLCSQPFSILGFGDIVVPGFLVAYCCRFDVQVCSRQIYFVACTVAYAVGLLVTFMAMVLMQMGQPALLYLVSSTLLTSLAVAACRQELSLFWTGQGRAKMCGLGCAPSAGSRQKQEGAADAHTASTLERGTSRGAGDLDSNPGEDTTEIVTISENEATNPEDRSDSSEGWSDAHLDPNELPFIPPGASEELMPLMPMAMLIPLMPLMPPPSELGHVHAQAQAHETGLPWAGLHKRKGLKVRKSMSTQAPL