wanglab/gogpt-training-data huggingface dataset:
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) (P32449)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Interaction partners:
- Pentafunctional AROM polypeptide
- Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited
- Chorismate mutase
- Chorismate synthase ARO2
- Transaminated amino acid decarboxylase
- Aromatic/aminoadipate aminotransferase 1
- Probable prephenate dehydratase
- Aromatic amino acid aminotransferase 2
- Prephenate dehydrogenase [NADP
- Anthranilate phosphoribosyltransferase
Sequence:
MSESPMFAANGMPKVNQGAEEDVRILGYDPLASPALLQVQIPATPTSLETAKRGRREAIDIITGKDDRVLVIVGPCSIHDLEAAQEYALRLKKLSDELKGDLSIIMRAYLEKPRTTVGWKGLINDPDVNNTFNINKGLQSARQLFVNLTNIGLPIGSEMLDTISPQYLADLVSFGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLNVAVDACQAAAHSHHFMGVTKHGVAAITTTKGNEHCFVILRGGKKGTNYDAKSVAEAKAQLPAGSNGLMIDYSHGNSNKDFRNQPKVNDVVCEQIANGENAITGVMIESNINEGNQGIPAEGKAGLKYGVSITDACIGWETTEDVLRKLAAAVRQRREVNKK
Protein: Eukaryotic translation initiation factor 5 (eIF-5) (P55010)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 1
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit D
Sequence:
MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPPPPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTIEERVNILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKAASVPKVETVKSDNKDDDIDIDAI
Protein: Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) (P56966)
Organism: Bos taurus (Bovine)
Function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Subcellular location: Cytoplasm {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95749}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O95749}.
Interaction partners:
- Farnesyl pyrophosphate synthase
- Diphosphomevalonate decarboxylase
- Isopentenyl-diphosphate Delta-isomerase 1
- Squalene synthase
- Decaprenyl diphosphate synthase subunit 2
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Alkyl transferase
- All trans-polyprenyl-diphosphate synthase PDSS1
- Protein farnesyltransferase subunit beta
- Dehydrodolichyl diphosphate synthase complex subunit NUS1
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLNHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLDTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLENVGSFEYTRNTLKELESKAYKQIDARGGNPELVALIKHLSKMFKEENE
Protein: Serine hydroxymethyltransferase 1 (SHMT 1) (EC 2.1.2.1) (Glycine hydroxymethyltransferase 1) (Serine methylase 1) (Q54Z26)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Interconversion of serine and glycine.
Interaction partners:
- Bifunctional purine biosynthetic protein purD
- Aminomethyltransferase, mitochondrial
- phosphoserine phosphatase
- Glycine dehydrogenase
- formate--tetrahydrofolate ligase
- Bifunctional purine biosynthesis protein purH
- methylenetetrahydrofolate reductase
- dihydrofolate reductase
- Serine--pyruvate aminotransferase
- Methionine synthase
Sequence:
MGSVSGNTPLKEVDNEIFELMNREKDRQFKGLELIASENFTSRAVMEALGSHFTNKYAEGYPGSRYYGGTEVVDELETLCQKRALKAFRLDESKWGVNVQPYSGSPANFAVYTALLRPHDRIMGLDLPSGGHLTHGYQTDKKKISASSIFFESMPYQIGADGLIDYQRLEENALLFKPKLIISGASAYPREWDYKRMRAIADKVGAYLMCDMAHYSGLVAAQLLDSPFDYCDVVTSTTHKTLRGPRSGIIFFRRGKRVDGNGKEIEEYDIESKINFAVFPSLQGGPHENVIAGVAVALKEADSQEFKEYALQVKKNAAAIGNALMNKGYKLVTNGTDNHLILWDLRPKELTGNKFEKAADIANITVNKNAVHGDTNAISPGGIRIGSSALTSRGLKEADFEKIADFLDRIVSISLEIQGRVGKKLVDFVVEINKSKELLDLRKEVEEFSSKFTLPGI
Protein: Proline-rich protein 11 (Q96HE9)
Organism: Homo sapiens (Human)
Function: Plays a critical role in cell cycle progression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23242552, ECO:0000269|PubMed:23246489}. Nucleus {ECO:0000269|PubMed:23246489}.
Interaction partners:
Sequence:
MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNCITQSLEVLKDTIFPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQPASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTLKPNSKVLSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENMETGTGLTPVMTQALRRKFQLAHPRSPTPTLPLSTSSFDEQN
Protein: Rho GTPase activating protein 4 (A0A8I6AN89)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV
Protein: Protein FAM118A (Q9NWS6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIPALCSWRSCIEAVIEAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKPSFFQDCLMEVFDDLEQHIRSPVVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPMESLDLKDKTKVLEWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYRTKSFLFVGCGETLRDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKVVSYGDCFDHFPGYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKKRTQSDTDDAGGS
Protein: Uncharacterized protein C777.12c (O74551)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Thioredoxin-like protein 1
- Thioredoxin reductase
- Tryptophan synthase
Sequence:
MKINLFFVFLFELLHFVAAYSCEGDESAAIEAMNVLQVPYEKYNTDPVCAFDNSTVVELSDKTWDHVIESGKWFVQLTAEGCANCTLGELLFNDLSHAFHEKYPDVHFARVYLSSSLELSVRLLISRIPSYYFIDNQNFYRVSPQVLPKNKAIALYEKDGFKSMKKEQGFFSVNGPLKSFYWVFGKALALYGHLSQKYTPLGMNVAIFGISAYIMYRSSKKAKQKQAAAAAAAAAKKK
Protein: Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (SERCA regulator DWORF) (Dwarf open reading frame) (DWORF) (Small transmembrane regulator of ion transport 1) (P0DN83)
Organism: Mus musculus (Mouse)
Function: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:26816378}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Myoregulin
- Sarcolipin
- Endoregulin
- Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN
Sequence:
MAEKESTSPHLIVPILLLVGWIVGCIIVIYIVFF
Protein: Malic enzyme (E1JIZ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pyruvate carboxylase
- L-lactate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Uncharacterized protein, isoform A
- Pyruvate dehydrogenase E1 component subunit alpha
- Malate dehydrogenase
- Malate dehydrogenase
- Probable citrate synthase, mitochondrial
- Malate dehydrogenase, mitochondrial
- Malate dehydrogenase
Sequence:
MFSRPSLCGTVGKLCRCGTSATGKTAVAAATVPTARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTEPLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGDKTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWPRMPYIKTRDLVPTKLYGKQKSEEVM
Protein: Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] (P24394)
Organism: Homo sapiens (Human)
Function: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Subcellular location: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- Interleukin-13 receptor subunit alpha-2
- Signal transducer and activator of transcription 6
- Tyrosine-protein kinase JAK1
- Cytokine receptor common subunit gamma
- Interleukin-4
- Interleukin-13 receptor subunit alpha-1
- Interleukin-13
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase JAK2
- Suppressor of cytokine signaling 5
Sequence:
MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS
Protein: Pyruvate carboxylase 1 (EC 6.4.1.1) (Pyruvic carboxylase 1) (PCB 1) (P11154)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Subcellular location: Cytoplasm.
Interaction partners:
- Pyruvate carboxylase 2
- Phosphoenolpyruvate carboxykinase
- Pyruvate kinase 1
- Citrate synthase, peroxisomal
- Malate dehydrogenase, cytoplasmic
- Citrate synthase 3, mitochondrial
- Citrate synthase, mitochondrial
- NAD-dependent malic enzyme, mitochondrial
- Malate dehydrogenase, peroxisomal
- Malate dehydrogenase, mitochondrial
Sequence:
MSQRKFAGLRDNFNLLGEKNKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKECGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADVAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGKKYNLDYYLEIAEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKTLIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIVEVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLEDQVPVETKA
Protein: ELMO/CED-12 family protein (Expressed protein) (O80516)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein kinase superfamily protein
- Putative reverse transcriptase/RNA-dependent DNA polymerase
- Putative non-LTR reverse transcriptase
- Ribonuclease H-like superfamily protein
- Reverse transcriptase-like protein
- Putative reverse transcriptase
- RNA-binding KH domain-containing protein RCF3
Sequence:
MDDREGSFVAVRRISQGLERGSVYNSSSAEAVPGSAAWLGRGLSCVCAQRRDSDANSTFDLTPAQEECLQSLQNRIDVAYDSTIPLHQEALRELWKLSFPEEELHGLISEQWKEMGWQGKDPSTDFRGGGFISLENLLYFARNFQKSFQDLLRKQVGDRSVWEYPFAVAGINLTFMLIQMLDLEAVKPRTIVGATFLKFLSENESAFDLLYCIAFKLMDQQWLSMRASYMEFNTVMKSTRRQLERELMLEDIMHLEDLPSYALLNQ
Protein: NAD-dependent histone deacetylase HST3 (EC 2.3.1.286) (Homologous to SIR2 protein 3) (Regulatory protein SIR2 homolog 3) (P53687)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Histone acetyltransferase RTT109
- Nicotinamidase
- Glutamine-dependent NAD
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- NAD-dependent histone deacetylase HST4
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- NAD
- NAD-capped RNA hydrolase NPY1
- Purine nucleoside phosphorylase
- Uridine nucleosidase
Sequence:
MTSVSPSPPASRSGSMCSDLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQIHSDCDNWVTFLESQIPDFFKTQDQIKKLRQLKREASDLRKQMKAQKDSIGTPPTTPLRTAQGIDIQGNNELNTKIKSLNTVKRKILSPENSSEEDEEENLDTRKRAKIRPTFGDNQAS
Protein: 26S proteasome regulatory subunit 4 homolog A (26S proteasome AAA-ATPase subunit RPT2a) (26S proteasome subunit 4 homolog A) (Protein HALTED ROOT) (Regulatory particle triple-A ATPase subunit 2a) (Q9SZD4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (Probable). Interacts with transit peptides of proteins targeted to the chloroplast, and may be involved in the degradation of unimported plastid protein precursors. Is required for the maintenance of postembryonic root and shoot meristems. Has a specific role in the regulation of organs size. Acts redundantly with RPT2B in the regulation of gametogenesis. With RPT2B plays a critical role in 26S proteasome assembly. Acts as an upstream signaling component for inducing both defense and morphological phenotypes in the constitutive active uni-1D mutant. Acts as negative regulator of endoreduplication in trichome cells. May function after the completion of the third endoreduplication step (8C to 16C) mediated by RHL1. Acts as negative regulator of transcriptional gene silencing (TGS) at specific endogenous genes through DNA methylation. Promotes post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Involved in tolerance to zinc deficiency, possibly through alleviation of oxidative stresses or processing of poly-ubiquitinated proteins. Required for resistance to the fungal pathogen Golovinomyces cichoracearum.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:22615900}. Nucleus {ECO:0000269|PubMed:22615900}. Note=Localizes to siRNA-bodies in the cytoplasm. {ECO:0000269|PubMed:22615900}.
Interaction partners:
- 26S proteasome regulatory subunit RPN13
- 26S proteasome non-ATPase regulatory subunit 1 homolog A
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome non-ATPase regulatory subunit 7 homolog B
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
- 26S proteasome regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 12 homolog A
- 26S proteasome non-ATPase regulatory subunit 8 homolog A
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit 13 homolog A
Sequence:
MGQGPSGGLNRQGDRKPDGGDKKEKKFEPAAPPARVGRKQRKQKGPEAAARLPTVTPSTKCKLRLLKLERIKDYLLMEEEFVANQERLKPQEEKAEEDRSKVDDLRGTPMSVGNLEELIDENHAIVSSSVGPEYYVGILSFVDKDQLEPGCSILMHNKVLSVVGILQDEVDPMVSVMKVEKAPLESYADIGGLEAQIQEIKEAVELPLTHPELYEDIGIKPPKGVILYGEPGTGKTLLAKAVANSTSATFLRVVGSELIQKYLGDGPKLVRELFRVADDLSPSIVFIDEIDAVGTKRYDAHSGGEREIQRTMLELLNQLDGFDSRGDVKVILATNRIESLDPALLRPGRIDRKIEFPLPDIKTRRRIFQIHTSKMTLSEDVNLEEFVMTKDEFSGADIKAICTEAGLLALRERRMKVTHPDFKKAKEKVMFKKKEGVPEGLYM
Protein: Transcription repressor OFP10 (Ovate family protein 10) (AtOFP10) (Q9FMS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that may regulate multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription repressor OFP14
- Transcription repressor OFP5
- Transcription repressor OFP15
- Transcription repressor OFP16
- Transcription repressor OFP12
- Transcription repressor OFP11
- Transcription repressor OFP17
- Transcription repressor OFP18
- Transcription repressor OFP13
- Probable transcription repressor OFP9
Sequence:
MLNLQAKLNEKKVPLLTNFPTPTSSLNNLNLFSLPLVKKKMSFKKMMKYILKTIFKPIFMACGCGSTVPPSSHSHYTPGPPVSPTVLRSPCPKIDESVAMAKESINPFEDYKKSMNQMIEERYIETESELKELLRCFLDINPSPQHNLIVRAFVDVCSHLQPPHDRRGKSLGRLLRLYVNNPLDNNDDDSHQTSSK
Protein: Rho GTPase-activating protein gacG (GTPase activating factor for raC protein G) (Q54QB9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Rho GTPase-activating protein gacH
Sequence:
MASIFLNKKTIETNNFIFNDNRPKNIKIVDKIKSSTVEFFHSIQKHIQQVKVENNNNNNNNNNNSENNKYKRSQSEENINNYIQNHFNPPQPQKKRNILFIFQNLINSGNSNNNNSSNSSCNSTPSTSPSSTPRSTNSPRSTYSPRNNNNNFTESSSDNQQFDITFNMVVEKERVILTVKVPEVGLTKKILFDKVETIKDAILLVIEKLPPGCLDASEYNLFLPQKNQWCKIDSRFSKYQFKENQEIEFKKDSRGGVSHMLSNVGNLLTRPYRTIYIKLPEIVTVGTLPPLQINGQIGDLPSLNNSLNNSLNNISSSSSGGTGGGSGTTAAATGSSLSNSNSNSNLQNSQSANNSPIIHRRRTSSFSYDPNIHHSSLTHSNSNSNLISTNTSSIGNSAPSPTTLGSKPFSIPKLNLTENNLNNSSSTSSSPRNNGNEVIQSSSSTSSPRVNAPPPLEHKKSFLNIIGISPRGTNRERSSSTNSLNNSTSSLKSSNNNILQQQQQQQQHYDSAPTTPRNFGTFVRTQQLQNQQQQLQQQESIEAFDFEDDSTLGEVLNKICTRYQYIEKDLLEDYSLITKDGLWFVDRNKTITELGLKHMDEVEFKRMTQKVKVVFLNKEIVLNFNPSDTLKEINYKIIVHYLPSLIKLSRSNSILSSSSSSIFLNHQSSSSSNSSSSPSQSYRSSLSLEPLVISDLENSQILSNTPTITTVGNHQILNLQQQQNKQRSYSDASPLSFSKDYTSEISNHQQQNIENHINRRKNSISTNPLTNSGNIANNNNNNNNNKDKDDNNNNNNNNNNNNNNNNNNNNNNNNNNIASSTDTIQSNSSTGSLGSNNNIAFSIQQNRYPIPDNLVEFKDFKLHLSGTKNQNPNINQKFDMLLDERRTLSSFNFWNNIKLHFKNSSKSLHSDSKRVAPTLPFYLQIESVEQFSVSHILELEGTLLISDILKSFNRLLLNNENIKINDPLDEYGLFFNTVNNGNREGLSYGSSIYLDPYKTLSHYPMIEPLDKLMFKRTNTIFGVDPNTIVSKIDPITGFNIPCLLLDLKQKFIELDGFSIEGIFKTNNYYDLTFTEIIKEIENGTLLTSNNPNVDAIGIACFIKRWFSKLPKKICSLLDDETLLYASTQESTAEASLDSIPQPYRSLLLWLVRFLSEVSQSAYTNKCSAKILAIVIAPNLISISPNNNNNNKENNDHHHHHHHHHNSHHHRDNNNNNSNNNSSTTPTSSSVGKYTSLEKLHQCTLFLRNLIKLKLRENGFLPISTSSISISNSHNSSSFISMTGTSETSIHSSNSPISSSISRSPSLTDIVEE
Protein: Capsid protein (CP) (Coat protein) (P03612)
Organism: Escherichia phage MS2 (Bacteriophage MS2)
Function: Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. The capsid contains also 1 copy of the A2 maturation protein.
Subcellular location: Virion {ECO:0000269|PubMed:8254664}. Note=The shell is composed of 178 copies of the capsid protein and 1 copy of the maturation protein. {ECO:0000269|PubMed:23810697, ECO:0000305|PubMed:8254664}.
Interaction partners:
Sequence:
MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY
Protein: Proliferating cell nuclear antigen (PCNA) (Q9DEA3)
Organism: Gallus gallus (Chicken)
Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P12004}.
Interaction partners:
- Replication factor C subunit 4
- Flap endonuclease 1
- DNA mismatch repair protein Msh6
- Replication factor C subunit 3
- Replication factor C subunit 2
- Uncharacterized protein.
- DNA ligase 1
- DNA polymerase eta
- Replication factor C subunit 5.
- Replication factor C subunit 1.
Sequence:
MFEARLVQGSVLKRVLEALKDLITEACWDLGSGGISLQSMDSSHVSLVQLTLRSEGFDTYRCDRNIAMGVNLNSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSAEFARICRDLSHIGDAVVISCAKDGVKFSANGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDQQEGS