wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-binding protein RFX2 (Regulatory factor X 2) (B2GV50)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that acts as a key regulator of spermatogenesis (By similarity). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858, ECO:0000269|PubMed:16676351}. Cytoplasm {ECO:0000269|PubMed:16676351}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm. {ECO:0000269|PubMed:16676351}.
Interaction partners:
- Serine/threonine-protein kinase ATR
- Multicilin
- Geminin coiled-coil domain containing
Sequence:
MQNSEGGADSPATVALRPAAQPVPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDPQLYAPSSAASYFETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHGGMDSTRHSLAHTARSSPATLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDGRASLPASDEEPEVTLLPKDKLISLCKCEPILQWMRSCDHILYQALVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI
Protein: Homeobox-leucine zipper protein ATHB-16 (HD-ZIP protein ATHB-16) (Homeodomain transcription factor ATHB-16) (Q940J1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that may function as a negative regulator of the flowering time response to photoperiod. May act to repress cell expansion during plant development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Delta-9 desaturase-like 1 protein
Sequence:
MKRLSSSDSMCGLISTSTDEQSPRGYGSNYQSMLEGYDEDATLIEEYSGNHHHMGLSEKKRRLKVDQVKALEKNFELENKLEPERKTKLAQELGLQPRQVAVWFQNRRARWKTKQLEKDYGVLKGQYDSLRHNFDSLRRDNDSLLQEISKIKAKVNGEEDNNNNKAITEGVKEEEVHKTDSIPSSPLQFLEHSSGFNYRRSFTDLRDLLPNSTVVEAGSSDSCDSSAVLNDETSSDNGRLTPPVTVTGGSFLQFVKTEQTEDHEDFLSGEEACGFFSDEQPPSLHWYSASDHWT
Protein: Abhydrolase domain-containing protein (EC 3.1.1.-) (Q54H38)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MFSSRDKAEVKLYFDSNNEENQKILDQCPHLYQKYDKDVTINDRINNIEDSEPTIKNGVTFYPPYYLYNSHFMNYYGSYKIPKLNLKTRREILVNPIDGGTISLDFFELGEFKEDTPTIVINHGLTGGSHERYVQYFAQRAYKEKGFRSVVFNYRGCAGNPITADRAYSAVQLDDIKFVTEYLTKTALPLVKKWFLVGFSLGSAILVNYMADAGKDSPYLAHVSISNPMNMVECTKNLSSTYINNLIYNKGLANNLKRLFRKFDGRLDKYATKEQIMAAQTIADFDDLITSKMFGFETAHDYYLAASSSKSIRNLVKPILFINAIDDPIAPTSGFPWKDFKSNPNTILCVSRWGGHLGFISYEDHMSWSDKAAVEYLSTFLDDNNNNNDNDNKTE
Protein: Hexosyltransferase (EC 2.4.1.-) (Q57YS1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MRTRRRRSQVYAFTLAVLIAISCLVVCCDLFFLSVIHLPLEEEKASAPINVDECLRLTAPSTVSIWQEREFLVIVGIPSVDRDEWQKRRNLQRRTCWQYAGVATLENNFTGELLPLYLLAPHQLNGYEISESLRDEASRTNDVVMLPTNDVCSFSRRKIGEGGSWGVESELVMSRKTFLWLQFAVTAFPNVSYIVKGDDDVFVRVPQYLADLRVMPRNGLYMGRVYGATFFWRSGGIPFAAGYFTTFSRDVAEAVASYRPLERLLKAPYSIWRMRQYLSMSVLHEDVMTALVLQDKIRYKGLIIVDAAPCHFHNAGKKGIRASLIDEYVVVHHIKENDYEVLMNHFADIAVQPKPSKVMWRSENYAVMQCFATLRLRRSALLALLSALGTTFRRHP
Protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 (EC 3.6.4.13) (O42643)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts late in the splicing of pre-mRNA. Required for the splicing of introns with a branch nucleotide to 3'-splice site distance greater or equal to 15. Mediates the release of the spliced mRNA from spliceosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor brr2
- Pre-mRNA-splicing factor slu7
- Pre-mRNA-splicing factor cwf3
- Pre-mRNA-splicing factor 18
- U2 small nuclear ribonucleoprotein A'
Sequence:
MDDLKELEYLSLVSKVASEIRNHTGIDDNTLAEFIINLHDQSKNYDEFKNNVLSCGGEFTDSFLQNISRLIKEIKPKDDIPTDNVNNGSNSVNGASHDLDSKDVDKQHQRKMFPGLSIPNSTNNLRDRPALMDNAMDELEELSTLAKTRRNDRDSRRDERHYLNGIRERRERSISPSFSHHSRTSISGQSHSSRSSRGPLLNAPTLYGIYSGVVSGIKDFGAFVTLDGFRKRTDGLVHISNIQLNGRLDHPSEAVSYGQPVFVKVIRIDESAKRISLSMKEVNQVTGEDLNPDQVSRSTKKGSGANAIPLSAQNSEIGHVNPLETFTSNGRKRLTSPEIWELQQLAASGAISATDIPELNDGFNTNNAAEINPEDDEDVEIELREEEPGFLAGQTKVSLKLSPIKVVKAPDGSLSRAAMQGQILANDRREIRQKEAKLKSEQEMEKQDLSLSWQDTMSNPQDRKFAQDVRDSAARQLTSETPSWRQATRNANISYGKRTTLSMKEQREGLPVFKLRKQFLEAVSKNQILVLLGETGSGKTTQITQYLAEEGYTSDSKMIGCTQPRRVAAMSVAKRVAEEVGCRVGEEVGYTIRFEDKTSRMTQIKYMTDGMLQRECLVDPLLSKYSVIILDEAHERTVATDVLFGLLKGTVLKRPDLKLIVTSATLDAERFSSYFYKCPIFTIPGRSYPVEIMYTKQPEADYLDAALMTVMQIHLSEGPGDILVFLTGQEEIDTSCEILYERSKMLGDSIPELVILPVYSALPSEIQSRIFEPAPPGGRKVVIATNIAETSLTIDGIYYVVDPGFVKQSCFDPKLGMDSLIVTPISQAQARQRSGRAGRTGPGKCYRLYTESAYRNEMLPSPIPEIQRQNLSHTILMLKAMGINDLLNFDFMDPPPAQTMIAALQNLYALSALDDEGLLTPLGRKMADFPMEPQLSKVLITSVELGCSEEMLSIIAMLSVPNIWSRPREKQQEADRQRAQFANPESDHLTLLNVYTTWKMNRCSDNWCYEHYIQARGMRRAEDVRKQLIRLMDRYRHPVVSCGRKRELILRALCSGYFTNVAKRDSHEGCYKTIVENAPVYMHPSGVLFGKAAEWVIYHELIQTSKEYMHTVSTVNPKWLVEVAPTFFKFANANQVSKTKKNLKVLPLYNRFEKPDEWRISKQRKGGR
Protein: Esculentin-2SE (P85055)
Organism: Lithobates sevosus (Dusky gopher frog) (Rana sevosa)
Function: Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against the Gram-negative bacterium E.coli K12 and Gram-positive bacterium M.luteus NCT C2665.
Subcellular location: Secreted {ECO:0000269|PubMed:16386333}.
Interaction partners:
Sequence:
GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC
Protein: Chitinase 3 (EC 3.2.1.14) (Basic endochitinase 1) (Class I chitinase c) (OsChia1c) (Pathogenesis related (PR)-3 chitinase 3) (P24626)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes chitin and plays a role in defense against fungal pathogens containing chitin. Inhibits the growth of T.reesei fungus on plate assay.
Interaction partners:
Sequence:
MRALALAVVAMAVVAVRGEQCGSQAGGALCPNCLCCSQYGWCGSTSDYCGAGCQSQCSGGCGGGPTPPSSGGGSGVASIISPSLFDQMLLHRNDQACAAKGFYTYDAFVAAANAYPDFATTGDADTCKREVAAFLAQTSHETTGGWPTAPDGPYSWGYCFKEENNGNAPTYCEPKPEWPCAAGKKYYGRGPIQITYNYNYGPAGQAIGSDLLNNPDLVASDATVSFKTAFWFWMTPQSPKPSCHAVITGQWTPSADDQAAGRVPGYGEITNIINGGVECGHGADDKVADRIGFYKRYCDMLGVSYGDNLDCYNQRPYPPS
Protein: Increased rDNA silencing protein 4 (P36115)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Seems also to be involved in rDNA silencing.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51
- Protein TAX4
Sequence:
MRLSFGKQRYHGGTTVTLTEQGASDSLRAAQAIFQNHSNEVSSPCPPVTVSRNPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAAALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLSSISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKIRNSANKTAHHRPIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHRHLNLLSWWPSITGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLPNVVEQCVWDSVDRYASTTVVPVSTLKAMAKQKRKQMKEEIKNIKKENRVVLVDHNSSS
Protein: Eukaryotic translation initiation factor 4G (eIF-4G) (eIF4G) (Protein cucumovirus multiplication 2) (Protein synthesis initiation factor 4G) (Q76E23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Plays a role in the accumulation of some potyvirus during viral infection. Required for the accumulation of cucumber mosaic virus 3a protein and turnip crinkle virus p28 replication protein during viral infection. These proteins are necessary for cell-to-cell movement of the virus.
Interaction partners:
- Eukaryotic translation initiation factor isoform 4E
- Eukaryotic translation initiation factor 4E-1
- Eukaryotic translation initiation factor 4E-2
- Eukaryotic translation initiation factor 4E-3
- Eukaryotic translation initiation factor NCBP
- Eukaryotic initiation factor 4A-1
- Eukaryotic initiation factor 4A-3
- Nuclear cap-binding protein subunit 1
- Eukaryotic initiation factor 4A-2
- Regulator of nonsense transcripts 1 homolog
Sequence:
MSYNQSRPDRSETQYRRTGRSTGNQQQQQQHRSSSAAGYGKGAGAPGSAPAPSTYPDNSSLSSNRSFKKPGNAQGGGQPRVNLPPVNHPNNHNNGPNAHSRSQVTGEPGVGGPTNPTESFNRNTGPIPKAPTSQSTVMSSKINETPNTAKVAASGDASQAFPLQFGSLGPDLMVPARTTSAPPNMDDQKRAQMQQSSLRTASNVPASVPKKDSSNKGADNQLMRKEGHNPSSEKADIQVPHIAPPSQTQKSPITNIRMPSVQTPYQHTQVPHPVHFGGPNMHMQTPVTATSFQMPMPMALSMGNTPQIPPQVFYQGHPPHPMHHQGMMHQAQGHGFATPMGAQIHPQLGHVGVGLSPQYPQQQGGKYGGARKTTPVKITHPDTHEELRLDRRGDPYSEGDSTALKPHSNPPPRSQPVSSFAPRPVNLVQPSYNSNTMIYPPVSVPLNNGPMSSAQAPRYHYPVIDGSQRVQLINQPAHTAPQLIRPAAPAHLSSDSTSSVKARNAQNVMSSALPVNAKVSVKPAGVSEKLGSPKDRSHGEVNISLSQKNVEACSLSSSQQPKPSFVSGVPNSSAPPAKSPVETVPLAKSSVETVPPVKSSVETAPVTTTEIRRAEMVSESISVEDQTCKVEPPHNLTENRGQTMPDSLVSDPETATVAAKENLSLPATNGFRKQLLKVSTTSDAPTSDSVDTSIDKSTEGSSHASSEISGSSPQEKDLKCDNRTASDKLDERSVISDAKHETLSGVLEKAQNEVDGATDVCPVSEKLAVTDDTSSDLPHSTHVLSSTVPLGHSETHKSAVETNTRRNTSTKGKKKIKEILQKADAAGTTSDLYMAYKGPEEKKESSNVVHDVSNQNLLPAIPQAVEAIVDTEPVKNEPEDWEDAADVSTPKLETADNSVNAKRGSSDEVSDNCINTEKKYSRDFLLKFADLCTALPEGFDVSPDIANALIVAYMGASHHEHDSYPTPGKVMDRQASGARLDRRPSNVAGDDRWTKNQGSLPAGYGGNVGFRPGQGGNSGVLRNPRMQGPIISRPMQPVGPMGGMGRNTPDLERWQRGSNFQQKGLFPSPHTPMQVMHKAERKYQVGTIADEEQAKQRQLKSILNKLTPQNFEKLFEQVKSVNIDNAVTLSGVISQIFDKALMEPTFCEMYADFCFHLSGALPDFNENGEKITFKRLLLNKCQEEFERGEKEEEEASRVAEEGQVEQTEEEREEKRLQVRRRMLGNIRLIGELYKKRMLTEKIMHACIQKLLGYNQDPHEENIEALCKLMSTIGVMIDHNKAKFQMDGYFEKMKMLSCKQELSSRVRFMLINAIDLRKNKWQERMKVEGPKKIEEVHRDAAQERQTQANRLSRGPSMNSSGRRGHMEFSSPRGGGGMLSPPAAQMGSYHGPPQGRGFSNQDIRFDDRPSYEPRMVPMPQRSVCEEPITLGPQGGLGQGMSIRRPAVASNTYQSDATQAGGGDSRRPAGGLNGFGSHRPASPVTHGRSSPQERGTAYVHREFASLSRASDLSPEVSSARQVLQGPSATVNSPRENALSEEQLENLSLSAIKEYYSARDENEIGMCMKDMNSPAYHPTMISLWVTDSFERKDKERDLLAKLLVNLVKSADNALNEVQLVKGFESVLKTLEDAVNDAPKAAEFLGRIFGKSVTEKVVTLTEIGRLIQEGGEEPGSLIEFGLGGDVLGSVLEMIKTEAGEETLVEIRRSSGLRIENFKPHAPNRSKILEKFT
Protein: TBC domain-containing protein C1952.17c (Q9URY3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May act as a GTPase-activating protein for Rab family protein(s).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MDYKQRIEKFKDILNSEEPISLPGLCSLCIQGIPDEYSLRAKAWMLMLEFLPTDRSNWQSVLEKHRKTYTSFVQELLIDPWRKLTLHEESGENSDHPLNTSDDSKWKEYFDDNQILEQIDKDIRRTLPDLSFFQGKSEINKKPSVNNVSENISVNTEDDKVEEVGQKLNYTKITSIDQSQETPVHLSTIDFSKFQEECHLVLQGRIYRLENESTSSSTTALSTPRQSMDSKRTINAEAIAGENKLGLHREAAERILFIYAKLNPGIGYVQGMNEILAPLYYVLATDPTYENYYLCECDAFFLFTQMMVQVRDLYEKTLDHDSDHGIHFLMSKFTERLKKYDYELWENLEEKQIHPTYYSFRWFTCLLSQEFPLPDVIRLWDSIIADQMKARLFGKNDDGFNGAYDFLMDFCCSILIELRESILERNFADSIKLLQAHFNVDMPKLLNLTFELQHLRKTSKNDEDMSYVRKNSYNTNALANSLKNRVLSTYNTVKANVPQSSSSYTDNNKQKEPLEEKRSFFPSFRSSLDGVSPTQGRKSGEENIRTIFAKPTAHIGENGWSNLKVKGSSIFQRFGNFVGDTMRYITEEEESSEEEDLTTSRRKIGITSKRKVSVKRNVI
Protein: Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II) (Q16775)
Organism: Homo sapiens (Human)
Function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Subcellular location: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:15117945}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15117945}.
Interaction partners:
- Lactoylglutathione lyase
- Probable D-lactate dehydrogenase, mitochondrial
- S-formylglutathione hydrolase
- Carboxylesterase 5A
- Acid-sensing ion channel 4
- Cocaine esterase
- Glycerol-3-phosphate phosphatase
- E3 ubiquitin-protein ligase makorin-2
Sequence:
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
Protein: Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499) (Q96K62)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 668
Sequence:
MAAAEAVHHIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVVAQGEALQVLTAASVLRIQTVIDECTQIIARARAPGTSAPTPLPTPVPPPLAPAQLRHRLRHLLAARPPGHPGAAHSRKQRQPARLQLPAPPTPAKAEGPDADPSLSAAPDDRGDEDDEESDDETDGEDGEGGGPGEGQAPPSFPDCAAGFLTAAADSACEEPPAPTGLADYSGAGRDFLRGAGSAEDVFPDSYVSTWHDEDGAVPEGCPTETPVQPDCILSGSRPPGVKTPGPPVALFPFHLGAPGPPAPPPSAPSGPAPAPPPAFYPTLQPEAAPSTQLGEVPAPSAAPTTAPSGTPARTPGAEPPTYECSHCRKTFSSRKNYTKHMFIHSGEKPHQCAVCWRSFSLRDYLLKHMVTHTGVRAFQCAVCAKRFTQKSSLNVHMRTHRPERAPCPACGKVFSHRALLERHLAAHPAP
Protein: Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (E2JDJ7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}.
Interaction partners:
Sequence:
MAITRWFFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLSSSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFSHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGAFVHWFPLFTGYTLHSTWTKIHFGIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLVSLVAVIMFLFILWEAFAAKREVASIELTSTNVEWLHGCPPPYHTFEEPAFVQVQAN
Protein: CD27 molecule (Similar to CD27 antigen-mouse, isoform CRA_b) (Q501W2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- CD70 antigen
- Tumor necrosis factor ligand superfamily member 4
- T-lymphocyte activation antigen CD86
- T-lymphocyte activation antigen CD80
- ICOS ligand
- T-cell surface glycoprotein CD4
- Tumor necrosis factor receptor superfamily member 4
- TNF receptor superfamily member 9
- CD19 molecule
- Tumor necrosis factor receptor superfamily member 8
Sequence:
MAWPPLYWLCMLGTLVGLLATPAPNNCPDRHYWIGAGLCCQMCGPGTFLVKHCDQDRAAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANAECTCSKGWQCRDQECTECDPPLNPALTSQPSEAPSPQLPPPTHLPYATEKPSWPPQRQLPDSTVYSRLPSQRPLCSSDCIRIFVTFSSMLLVFVLGGILFFHQRRNHGPNEDSQAVPEELCPYSCPREEEGSVIPIQEDYRKPEPASYP
Protein: Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7) (P97605)
Organism: Rattus norvegicus (Rat)
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Membrane, caveola {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Compartmentalized in discrete caveolae-like membrane microdomains. {ECO:0000250}.
Interaction partners:
- receptor protein-tyrosine kinase
- Ephrin type-A receptor 3
- receptor protein-tyrosine kinase
- Ephrin type-B receptor 1
- Ephrin type-A receptor 5
- Ephrin type-A receptor 2
- Ephrin type-A receptor 7
- Ephrin type-A receptor 1
- Ephrin type-A receptor 6
- Ephrin type-A receptor 8
Sequence:
MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVRDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
Protein: ADP-ribosylation factor (Q9LYJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555, ECO:0000256|RuleBase:RU369003}.
Interaction partners:
- Brefeldin A-inhibited guanine nucleotide-exchange protein 5
- ARF guanine-nucleotide exchange factor GNL2
- Kinesin-like protein KIN-14E
- ADP-ribosylation factor GTPase-activating protein AGD7
- Arabidiol synthase
- Coatomer subunit gamma
- Ras-related protein RABG3c
- ARF guanine-nucleotide exchange factor GNL1
- Protein transport Sec1b
- Syntaxin-132
Sequence:
MGLNFTKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIATKVNNLNIPF
Protein: Actin-associated protein FAM107A (Q78TU8)
Organism: Mus musculus (Mouse)
Function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O95990}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21969592}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O95990}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O95990}. Synapse {ECO:0000269|PubMed:21969592}. Note=Colocalizes with F-actin (PubMed:21969592). Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles (By similarity). {ECO:0000250|UniProtKB:O95990, ECO:0000269|PubMed:21969592}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase zeta
Sequence:
MYSEIQRERADIEGLMARPEYREWNSELIKPKKLLNPVKASRSHQELHRELLMNHKRGLGMDSKPELQRVLEHRRRNQLIKKKEEELEAKRMQCPFKQELLRRQQRLNQLENPPQRDEDHAPEFIKVRENLRRITTLTSEERAL
Protein: Grainyhead-like transcription factor 2b (A0A2R8QAV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU01313}.
Interaction partners:
Sequence:
MMSINGDEDSAAALGLLYEYYKVPKDKRVPISKVVEMSDEPEKRSTPVGNSSQMEPETVDNHVQVLKSVPVNLSLNTDHQDNKREQYSVPAGESGTAAVVKAEAHTAVFMTSGGHYRTEGEEQMRVICEQTHSFDTSTINHSAYGKDDHRSSPESTYEDDSNEKYRSSSIGPDDFIFDQSHMLDTFQYTLEASKSLRQKQGEGPMTYLNKGQFYAITLSETSANKRLRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDLNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPLHRAYCQIKVFCDKGAERKIRDEERKQNRKKTKGKDGGSGTVTVPKKCDSTLFKTMTDLDAQPVLFIPDVHFGNLQRAGQVFAFNTEEIECEGSVLVKRMFRSSEEDFCPPPHKQLREDTQKRVLLYVRKESDEVFDALMLRSPTVRGLMDAISEKYGVPIDRMAKIYKKSKKGILVNMDDNIIEHYSNEDTFILNIESYADAYKITLTEI
Protein: NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 6) (NADH-plastoquinone oxidoreductase subunit 6) (P0C330)
Organism: Oryza sativa subsp. indica (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
Sequence:
MDLPGPIHEILVLFGGFVLLLGGLGVVLLTNPTFSAFSLGLVLVCISLFYILLNSYFVAVAQLLIYVGAINVLIIFAVMFVNGSEWSKDKNFWTIGDGFTSLVCITIPFSLMTTIPDTSWYGILWTTRSNQIVEQGLINNVQQIGIHLATDFYLPFELISIILLVSLIGAITMARQ
Protein: Aspartate beta-hydroxylase (E5RG56)
Organism: Homo sapiens (Human)
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004157}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004157}.
Interaction partners:
Sequence:
MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQVYEEQVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPDT
Protein: Alpha pinene synthase, chloroplastic (LpPINS) (EC 4.2.3.-) (T1RR71)
Organism: Lavandula pedunculata subsp. lusitanica (French lavender)
Function: Monoterpene synthase involved in the biosynthesis of volatile compounds widely used in aromatherapy and folk medicine, and present in culinary herbs. Mediates the conversion of (2E)-geranyl diphosphate (GPP) into alpha-pinene and, as minor compounds, into alpha-phellandrene, limonene and alpha-terpinolene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSSISMHAGPLNISAANNHHPSWDRRVSKPRRVAAKHLGLRLSCSLQLDGKPLDETRRSANYQPSAWDFNFIQSLHNQYKEDKYVTRHTELTAQVKMLLEEETDAVQQLDLIEDLKNLGINYLFKDKIQQILNHIYNQHRCFQNNQVEGNDLYFTALGFRLLRQHGFEVSQEVFDRFTNEEGTDFNPSLIDDTKGLLQLYEASFLLREGEDTLELARQFSTKLLQKKVDEDGDREVGDNLLVWIRHSLELPLHWRIHRIEARWFLDAYATRHDMNPIIFELAKLDFNITQATQQEELRDLSRWWNSAGLVEKLSFARDRVVESYFWAIGTLEPRQYGYQRKLVAKIIALISVVDDVYDIYGTLDELKLFTDVMRRWDAESFDQLPYYMKICYLIINNFIFELAYDILKDKGFNSLSYLQRSWLDVVEGYFTEAKWYYSGYTPNLEEYLKNAKITVTCPMILSQIYFTIASSIEKPELESMYKYHDILYLSGLLLRLPDDLGTALHELKRGDAPKAMQCYMKEKNVPEKEAREHVRFLIREASKQMNTVSAADCPFPDDFVAAAANLGRVANFVYVDGDGFGDQHSKMLQQIAALMFEPYD