wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.27) (D4A7F0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ubiquitin protein ligase E3 component n-recognin 7
Sequence:
IMAAAAAAAVGGPQPPQPEVSAQGPTLDKAATAAHLKAALSRPDNRAGAEELQALLERVLNAERPLARAAGGEEAAGGGSPGEAEEDALEWCKCLLAGGGGYDEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCRRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPADTPSEKDLNKVLQLLEPQISFLEDLTKTGGAMRAVLTQVLTNQQSYKDLTAGLGENTCAKKSHEKYLIALKSSGLTYPEDKLVYGIQEPSAGTSTLAAQGFAGATGTLGQIDSSDEEDQDGSQGLGKRKRVKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSLLPDQEMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLTMASQHHNMVLDVEHERSMLEGALTFLVILLSLRLHLGMSDDEILRAEMVAQLCMNDRTHSSLLDLISFENVIFGIIPGSYSFESVLSAVADFKAPVFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFSGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLEDSAEDDSEEEVSMGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPELKRDSLASTSSDGLGSLQNSGTAQVFSLVAERRKKFQEIINRNNSEANQVVRPKTPSKWSAPGSAPQLTTAILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEVLIQPEIPKYSHGDGITAVERILLKAAVQSRMNKRIIEEICRKVTPPVPPKKITTAEKKTLDKEERRQKARERQQKLLAEFASRQKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQASSVLGQCRDNVEPKKLPITEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGGVYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVENNLWQRPSNKSTQDLIKEVEELQGRPGAFPVSISSETNLSKEMESVMKDIKNTTQKKYRDYSKTPGSPDNDFLFMYSVARTNLELELIHRGGSLCSGGASTAGKRSCLNQLFHVLALHMRLYTIDSEYNPWKKLTHLVEDMNSQVGSEDQQPEVPVLYHDVTSLLLIQILMMPQPLQKEHFTCIVKVLFTLLYTQALAALSVKGTEEDRSAWKHLGALKKDTCDAEKSYEVLLGFVISELSKGKLYCEEGAQECTMVSPIAWSPESMERYIQDFCLPFLRISSLLQHHLFGEDLPSCQEEEEFSVLASCLGLLPTFYQTDHPFISASCLDWPVAAFDIITQWCFEIRSFTERHAEQGKALLIQESRWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGAFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSHTFDHINKRWGPHYNGL
Protein: EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein) (Q9Y3C4)
Organism: Homo sapiens (Human)
Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12659830, ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:12659830, ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:28805828}.
Interaction partners:
- EKC/KEOPS complex subunit LAGE3
- EKC/KEOPS complex subunit GON7
- tRNA N6-adenosine threonylcarbamoyltransferase
- EKC/KEOPS complex subunit TP53RK
- tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
- Threonylcarbamoyl-AMP synthase
- Nucleoporin Nup43
Sequence:
MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL
Protein: U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) (Q96DI7)
Organism: Homo sapiens (Human)
Function: Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome.
Subcellular location: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9731529}.
Interaction partners:
- Pre-mRNA-processing factor 19
- Pre-mRNA-processing factor 17
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-processing-splicing factor 8
- Small nuclear ribonucleoprotein E
- Cell division cycle 5-like protein
- Pre-mRNA-processing factor 6
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-splicing factor SPF27
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (EC 3.1.4.11) (Q804J6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAASAGFSSNGPVPWALSDTEVNNLYRDLELGTVLTLYYSKKSQRPERRTFQVKLETRQIIWTRGTDKIEGEIDIREIKEIRTGQKSRDFERYVEDVTTRPDQAHCFVILYGTEFRLKSLSLAATSDEEMVMWVKGLTWLMSDTLSSSTPLQIERWLRKQFYAVDRNREDRISCKDLKCMLCQVNYRVPNMKFLREKLPDGELRNGDVSYSHFAQLYRSLMFDAQKSMEIPLLQRFIDRPEQKISLEDFQNFLIEQQKELWAADSNKVQEYMFRYLKDPLREIEQPYFHQDEFLTYLFSKENTIWDAQLDQVRPEDMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLNTIKEHAFVTSDYPIILSIEDHCSIVQQRNMATFFKKVFGEMLLTKAVDISADGLPSPHQLKRKILIKHKKLAEGSAYEEVSSSTPYSENDISNSIKNGILYLEDPINHEWYPHFFVLTSNKIYYSEETSSNQGNEDEEEHREICNGMDQHVTEKWFHGKLGAGRDGRQIAERLLSEYCVETGAPDGSFLVRESETFVGDYTLSFWRSGRVQHCRIHSRQEAGSPKFYLTDNLVFDTLFALITHYQQVPLRCNEFEMKLTEPVPQTNAHESKEWYHACLSRSQAENMLMRVPRDGAFLVRKRTEFNSFAISFRAEGKIKHCRVQQEGQTVVLGTSEFDSLVDLISYYEKHPLYRKMKLRYPINEETLEKIGTAEPDYGSLYEGRNPGFYVEANQMPTFKCTVKAMYEYKAQRDDELSFIKNAIISNVDKQEGGWWKGDCGGKKQLWFPANYVEEISPTAVEPDRSASENSPLGDLLRGSVDVSSCQIVVRPEGKGSRQFVFSLVPVASPRTGPVLDIAASSQEELKDWVVKIREVTMTSEAKLEEGKMMERRKKIALELSDLVIYCRPVPFDEDKIGTERACFRDMSSFPETKAEKYVNRVKGKKFLQYNRLQLSRIYPRGQRLDSSNYDPLPMWLCGSQLVALNFQTADKPMQMNQAIFMLNGRSGYVLQPPIMRDDNFDPFDRHSLRGVEPITLSIEVLGARHLPKHGRGIVCPLIEIEVCGAEYDNAKQRTDSEADNGLNPTWTRKLFRFTVCNPSFAFLRFVVYEIDMFSDQNFLAQATFPINCLKTGYRSVPLKNSYSEDLELACLLVHMDVIRGRVGYEMIHENGDMLSPFSPAGAMAMAMQTGRERMNDSGSVSSTSSMSPLPSSPAQALGYRGREGSFEARYQTPLEDFRVSQEALLDHENRRLRRARVSADNRA
Protein: Zinc finger protein 488 (Q96MN9)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5HZG9}.
Interaction partners:
Sequence:
MPEWPPCLSVAPALVITMAAGKGAPLSPSAENRWRLSEPELGRGCKPVLLEKTNRLGPEAAVGRAGRDVGSAELALLVAPGKPRPGKPLPPKTRGEQRQSAFTELPRMKDRQVDAQAQEREHDDPTGQPGAPQLTQNIPRGPAGSKVFSVWPSGARSEQRSAFSKPTKRPAERPELTSVFPAGESADALGELSGLLNTTDLACWGRLSTPKLLVGDLWNLQALPQNAPLCSTFLGAPTLWLEHTQAQVPPPSSSSTTSWALLPPTLTSLGLSTQNWCAKCNLSFRLTSDLVFHMRSHHKKEHAGPDPHSQKRREEALACPVCQEHFRERHHLSRHMTSHS
Protein: Vacuolar protein-sorting-associated protein 36 (O43038)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (By similarity). Required for vacuolar sorting of carboxypeptidase S (CPS).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Vacuolar protein-sorting-associated protein 25
- Vacuolar-sorting protein dot2
- Vacuolar protein sorting-associated protein 28 homolog
- Vacuolar protein sorting-associated protein 20
- Vacuolar protein sorting-associated protein 27
- Vacuolar-sorting protein snf7
- ESCRT-III complex subunit did4
- Vacuolar protein sorting-associated protein 24
- Vacuolar protein-sorting-associated protein 46
- Vacuolar protein-sorting protein bro1
Sequence:
MAFYLETTPSNLPVLDPSEEILLVQDQVGLYFGDEKSFRHNNGTLYLTKKHIFYVDSVDPKKNSLKIKISDIRDVQHTSRYFRSSPKIRLSLRHVEKSWACKICTFINVGDPINPCRNCGVANRFTIIKPKSDARFSQGLCTACTFQNYPDLNTCEICGNQLKNVDRNQLIQLSFRGSGSSKFYEAIKSETDEIEKQRYSNKYDTKVLRKAILEKSLRMGGIHDLEQSHEMQLAKNGRTLVHAFQDLDAFFSLAKDTMSLADQFAEKMDGLTGTQQSDKVQQLLNKSNQLGVLRGNHLDNVPVSANSRLYDIELCKSISEVLRTRLKADTDTVTMTQAWAIYNRSRKANLIPPTRFVKACELIDSMEVGITTSKMNSGLILFQLKTSNHSGKLLSAILEVMNPSTTALKCAMRLHWSIGVTLERLYQAEMDGYIVRDVYEESGSSLLYWKNEFDELSEELTKWFDES
Protein: Shikimate kinase 2 (SK 2) (EC 2.7.1.71) (Shikimate kinase II) (SKII) (P0A6E1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- 3-phosphoshikimate 1-carboxyvinyltransferase
- 3-dehydroquinate synthase
- Quinate/shikimate dehydrogenase
- Shikimate dehydrogenase
- Chorismate synthase
- T-protein
- Shikimate kinase 1
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
- 3-dehydroquinate dehydratase
- Bifunctional chorismate mutase/prephenate dehydratase
Sequence:
MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
Protein: Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) (Q8NEM7)
Organism: Homo sapiens (Human)
Function: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.
Subcellular location: Nucleus {ECO:0000269|PubMed:19893488}.
Interaction partners:
- SAGA-associated factor 29
- Transformation/transcription domain-associated protein
- Transcription initiation factor TFIID subunit 9
- Transcriptional adapter 3
- Transcriptional adapter 1
- Transcription initiation protein SPT3 homolog
- Ataxin-7
- STAGA complex 65 subunit gamma
- TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
- Transcription initiation factor TFIID subunit 12
Sequence:
MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKRYSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAIPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYVFECEAGTQYQKTKLTILQSLGDPLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSASLSQVSPGKETDQTETVSVQSSVLGKGVKHRPPPIKLPSSSGNSSSGNYFTPQQTSSFLKSPTPPPSSKPSSIPRKSSVDLNQVSMLSPAALSPASSSQRTTATQVMANSAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQAASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQLSQFTPQQPQQPTTCSPQQPGEQGSEQGSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRFQLSSAFQQQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPTTPKF
Protein: Surfeit locus protein 4 homolog (O18405)
Organism: Drosophila melanogaster (Fruit fly)
Function: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Golgi SNAP receptor complex member 1
- Uncharacterized protein, isoform C
- Ergic53, isoform A
- DSec61alpha
- SURF1-like protein
- CHOp24, isoform A
- Transmembrane emp24 domain-containing protein bai
- ER lumen protein-retaining receptor
- P24-related-1, isoform A
- Protein transport protein SEC23
Sequence:
MSIPNEYIAKTEDVAEQVIKRGKNVLPTVARLCLIATFFEDGLRMYIQWNEQREYMDMSWGCGKFLATVFVLVNLLGQLGGCGMVMARFKVDIAVGLLFFIVVLQTVAYSILWDFQFLLRNFALIGALLLVLAEARIEGRSLFAGVPSMGENKPKNFMQLAGRILLAFMFITLIRFELSVWQVIQDIIGSILMVLVVLGYKTKLSALILVALLTILNLYHNAWWTIPSYKPLRDFLKYDFFQTLSVIGGLLMIVSLGPGGVSMDEHKKKW
Protein: Tel2-interacting protein 2 (O94729)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the tel2-tti1-tti2 (TTT) complex that stabilizes protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC) (By similarity). Component of the ASTRA complex involved in chromatin remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000305|PubMed:27935167}.
Interaction partners:
- DNA replication checkpoint protein tel2
- TEL2-interacting protein 1
- SAGA complex/NuA4 acetyltransferase complex subunit Tra1
- RuvB-like helicase 1
- ASTRA-associated protein 1
- RuvB-like helicase 2
Sequence:
MQYYKELARRLHTLQSKNEKEALEKQIDFLDKLVVEVDSLVHEQDLRPLLEFISPTESWFLLGTATIFYIKLLTHPDPESIDVVIKEAYVVRAHRILSIFQEQFIENVVKEINWEILAILISLSGIENGLVRNLSEFLSTSILSAVPRQKFLLYLLEKYQINLFHREERLTDQGRPVAFELPPDKFHSDQSKALLEPKWKTKNYLISHLIFWIIDQQSSSSIEVCWHRIIPSVLRILNDLSPNIKLQGIELVNRLLKITEREFLLYTGILKILKDDLLVFYTFIPPRFTIQTSVTLINASFATLVSLYPEENENLNSIMLNGINSVFQFAFDYPLILQAAFSQIMVLTDKMNVSYLPYLTLTLDELCRIIQNPQIIQIPSTLSFFLEILTKLLEIYSYRISAHHVELLMALVVCSRNYMRCNLQEHHNAIVQALQNLFTLIKLNITVEQLGDYNVILPLLEPLQIPL
Protein: Serine/threonine-protein phosphatase PPQ (EC 3.1.3.16) (P32945)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Phosphatase involved in the regulation of protein synthesis. Affects translational accuracy.
Interaction partners:
- Type 1 phosphatases regulator YPI1
- COMPASS component SWD2
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Polyadenylation factor subunit 2
- RNA end formation protein 2
- Protein MPE1
- Protein phosphatase 1 regulatory subunit SDS22
- UBX domain-containing protein 1
- Endoribonuclease YSH1
- Cleavage factor two protein 2
Sequence:
MRRSPSRSNNNFAVPNCSTNSNSSQQQLTTPSDDLNSNEPNDPDDSRSLPTIKKFNNKHSINNYNTLASAGKNNNNKRASNDNLLIPGENAHKQKIYTKDENLKSLYLDIDVSVAKALSSSATAPKLINTARTSSTTTATTSNNILTSPSYRESNYSSPSSYSFSSYYSSATSASSSTSSFLKSSGLSSRVKSPSSSVKAGSFGAPSSPTSGIPNPKSSKKPIFLRRYSHDTSSNEGLDIDVAIEKLLQVGESREITKTSKKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRALKNKKKLYKTKV
Protein: Anthranilate phosphoribosyltransferase (EC 2.4.2.18) (O60122)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Multifunctional tryptophan biosynthesis protein
- Tryptophan synthase
- Probable anthranilate synthase component 1
- Putative aminodeoxychorismate synthase
- Chorismate synthase
- Probable glutamate 5-kinase
- Pentafunctional AROM polypeptide
- Chorismate mutase
- Homoserine kinase
- Adenine phosphoribosyltransferase
Sequence:
MINTFNPEVRLAIHDLDKVGPAIPLENYEAALRAILTGKASPVETASFLASLHLTKAEEVPDILMQTVQILKSYSTPIANIEMVSPRFVDIVGTGGDGHNTFNVSTASAIVAAGAGLWVCKHGNKASTSASGSADLLMSFGCDLLNVTPKNIVSITEQCKFSFLFAPMCHPTLKNVAPIRKQLGLPTIFNLVGPLLNPIPTYARIIGVSKLSLGEVVAKTLLKLGAGRSLVVCGEEGLDEISPAGPTHTWLVRDGTITHEVYTPESFHLQSHPLSSVASGTPSANAILLEELLSNMLHANHPILDYVLMNTAALLHVAGMAESLREGVKIAQQSISSGAALRELSNFSTISQQP
Protein: Tousled-like kinase, isoform B (EC 2.7.11.1) (Q8IRT8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPRLRCDDVAAVLLPLMMLLLLLLLLLRRLVVVVVGHFIIDKQQEQEQEQQHQQQQQQQRHRLLAKTKQRTRTSADKKDDLCPHQFSFGFSRNSNAIKIKTAPSYQQHFHHQNLHHHQQQHQQQQQQQHITQVQQQQQQQQQLLVLPQQQQQQHLRVCNNQINNNNNSSNSCQNSYQYSYNNNNNNTNANNNSNQQLQQQIVNNNNNLEDDVYYLFYKDFYMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS
Protein: Peroxisomal ATPase PEX1 (Peroxin-1) (C8V3A3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal receptor
- Peroxisomal membrane protein PEX14
- Peroxisome assembly protein 12
- RING-type E3 ubiquitin transferase
- Peroxin-7
- Ubiquitin-conjugating enzyme E2 2
- Peroxisomal membrane protein PEX14
- Microbody
Sequence:
MAPRKPSTTAEVALVSLKNCLVNLPPSLVSLLVNANTPAQNVIVELQFRPTGRTNSGSTTPRSCYLGWTGMPSKRRIAPVVGRDGINNSPSTREQDAATVELDTTFGRFLGLGDGQRVGIFIHLDPPVAHTINIEPLTPEDWEIIELHATFLELNLLSQIRALPNPTYTAAQADHMHPLTLHLSPTSTANIVITSLTPAPPSTSPFAKIAPDAEVIVAPKTRPKANTRVSRGDNRSVTGSSKRSAGGRSSGGSTARGKSSKSETSRGALYFRGLDRQWSDQYFDEESEEDNNEGFRVWLDPDVLASNELRGAEWACVTLVQPSGLKPPSDPQQQMSQAEQKASDSGAPTTKLVAKLLPWIDAPDTQHAGLSSLLCSAIGAEGMVGGIIRVEAAPPPLQRSATRALKVYPFLADATKRNDGLKFGADTIAAKDALVERIKVLYGSTGSGRGLLTGPITDGMVLPKSDNQGTVSAFDGALIRFDPPLKSTSDASKSVFGWLLGSDAKLPLEIQAEIPKPANQSALNLTMEDPIPATAPPMVGIDQVISQALDNLNKSCSVLVTGGLGSGKTALGQLLAHRLQKESLFNVKYFSCRKLVTDETRISNIKETLNRLFMSAAWCARLGGQSTVILDDLDKLCPVETELQVGGDNGRSRQNSEVICSMVREFCSMNSGVVLLATAQSKESLNNVIVGGHVFREVIHLRAPDKEGRRKVLEYLTSQDRRTTSATAEAGPSGATNGHTRTVSTSTNDSWLDPSNPGSRPSSSGGDGFILGRDVDFLDLAGKTDGFMPGDLVLLVARARNEALIRSISEASDESRAIILGAADFDNAIKGFTPASLRNVTLTSSTTTFSAIGGLHETRKMLLETLQYPTKYAPIFAQCPLRLRSGLLLYGYPGCGKTMLASAVAGECGLNFISVKGPEILNKYIGASEKSVRDLFERAQAARPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLSGVYVLAATSRPDLIDPALLRPGRLDKSLLCDMPNHADRADIIRAVSKKLAMSNEVVARIDEVAARTAGFSGADLQAVVYNAHLEAVHDALGDRSGDKPPAKTAKSSTPSTSSRSFIQFLYSDLEQRAGTVAMPAPAVVASKLDALKNARRRQRQFEQAAGSLAPTTATDNAHETGPAEGREEIVVRWEHMERSLNTTRSSLSEAERRRLLAIYREFVEGRNGEMPNGEGAREVGGRTSLM
Protein: Candida glabrata strain CBS138 chromosome G complete sequence (Q6FSS6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- 40S ribosomal protein S30
- 60S ribosomal protein L6
- Large ribosomal subunit protein eL38
- 60S ribosomal protein L8
- Ribosomal protein L37
- S16a
- Large ribosomal subunit protein eL31
- 60S ribosomal protein L29
- Candida glabrata strain CBS138 chromosome F complete sequence
- 40S ribosomal protein S26
Sequence:
MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHKKVKLAVLSYYKVDGEGTVTKLRKECSNPTCGAGVFLADHKTRLYCGKCHSVYKVDA
Protein: PE family protein PE9 (Q79FS8)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Together with PE10, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF-3, increase in the transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10, down-regulation of IL-1b and enhanced levels of macrophage apoptosis.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:26031846}. Cell surface {ECO:0000269|PubMed:26851205}.
Interaction partners:
- PE family protein PE10
Sequence:
MSYMIATPAALTAAATDIDGIGSAVSVANAAAVAATTGVLAAGGDEVLAAIARLFNANAEEYHALSAQVAAFQTLFVRTLTGGCGVFRRRRGRQCVTAAEHRAAGAGRRQRRRRSGDGQWRLRQQRHFGCGGQPEFRQHSEHRR
Protein: Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Q388P2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Farnesyl pyrophosphate synthase
- Isopentenyl-diphosphate delta-isomerase, putative
- phosphomevalonate kinase
- Diphosphomevalonate decarboxylase
- Mevalonate kinase
- Hydroxymethylglutaryl-CoA synthase
- Lanosterol synthase
Sequence:
MSDQCVTVEAPINIAFIKYWGKREGGETLILPTNDSFSITLSASPFRSKTSVELRDDIETDTLRLNGTEVDVGKTPRVQSMLLHLRSTCPEDLKNKKVNIVSENNFPTAAGMASSASGYCAMSAALIRAFKSTTNVSMLARLGSGSACRSAFGGFVIWNKGEKPDGSDCVATQFVDETHWPEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEICATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVLKEDLPEAVAMLMEHFPTPFEKFFFGDRELLEKVKVVSLPDEYKKLIDHPKKPFEMLLQSPVGCGVKYLGPSESLIPPRV
Protein: GDP-mannose 4,6-dehydratase (EC 4.2.1.47) (Q387W4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GDP-L-fucose synthase
- mannose-1-phosphate guanylyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- Glycosyltransferase, putative
- UDP-glucose 4-epimerase
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Phosphoacetylglucosamine mutase
- Glucosamine 6-phosphate N-acetyltransferase
Sequence:
MSARRLALITGITGQDGSYLAELLLKKGYDVHGIVRRSSSLNTGRIDHLVGNAHLHLHYGDMTDGAGLHQIVSRVRPHEVYNLAAQSHVKISFETPVYTGETDALGTAKILEAIRSTGLEKTCRFYQASSSELYGNVQEAPQTERTPFYPRSPYAVAKLYSHWITVNYRESYDMFASNGILFNHESPRRGEAFVTKKIVRAAVRITRGMQKELFLGNVNAVRDWGHAKDYVHGMWLILQADKPDDWVLATGKQHSVKEFCNLAFQRLGVNLAWAGSGLDEIAYDRGCALRTPIVRIDSRLFRPAEVETLVGNPEKAARELGWKITYSFEQLVEDMVEAELREMDGNKGCERLAGKCITAETS
Protein: Putative T-box protein 39 (Q9NA56)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- Putative T-box protein 33
- HMG box domain-containing protein
- Zinc finger transcription factor family protein 17
- Forkhead box protein fkh-4
Sequence:
MFSQAQFNVTMAEEDRWKQWYPNMEMIVNNKGPKLIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVRHATKKEQEIKYFLHPDGTKLGKELMKETIKFDTVRITNHKKFMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVAQFFPVTVYNQESIGNWKSKFHKNSTYGNRLDGGNKRKNTDSSEERTSKRSKNETEIAVSDILQVASQSENYNESTNSGRLQNEISSSIHQFPSTSYQNQYPHAYPTVNTPPIYVQQFTALFDEIHNQFDPKTKQNRVAKNVQYLSSVPQFAINQKENIHQNAPDYPVSQFPNQYPYGSYPYYYPYFQSSQQFPHLNYSMNNSIYSDSSFQSSFSAENSYFDENGNPIHYPYYSSN