wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphate transport system permease protein PstC 2 (P9WG05)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- Phosphate-binding protein PstS 3
- Phosphate transport system permease protein PstA 1
- Phosphate import ATP-binding protein PstB 1
- Phosphate import ATP-binding protein PstB 2
- Phosphate-binding protein PstS 2
- Phosphate transport system permease protein PstA 2
- Phosphate-binding protein PstS 1
- Phosphate transport system permease protein PstC 1
- Phosphate-specific transport system accessory protein PhoU homolog 1
- Phosphate-specific transport system accessory protein PhoU homolog 2
Sequence:
MVTEPLTKPALVAVDMRPARRGERLFKLAASAAGSTIVIAILLIAIFLLVRAVPSLRANHANFFTSTQFDTSDDEQLAFGVRDLFMVTALSSITALVLAVPVAVGIAVFLTHYAPRRLSRPFGAMVDLLAAVPSIIFGLWGIFVLAPKLEPIARFLNRNLGWLFLFKQGNVSLAGGGTIFTAGIVLSVMILPIVTSISREVFRQTPLIQIEAALALGATKWEVVRMTVLPYGRSGVVAASMLGLGRALGETVAVLVILRSAARPGTWSLFDGGYTFASKIASAASEFSEPLPTGAYISAGFALFVLTFLVNAAARAIAGGKVNG
Protein: Spore germination protein 1 (SPG1) (P15519)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Stalk-specific protein A
- Spore germination protein 270-11
Sequence:
MNIKNSLILIISTIFVLSMINGGLTSDPTCVGAPDGQVYLFSSWDFQGERYVYNISQGYLSLPDGFRNNIQSFVSGADVCFVKWYPSEQYQITAGESHRNYAALTNFGQRMDAIIPGNCSNIVCSPK
Protein: Heme d1 biosynthesis protein NirJ (G3XD10)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Siroheme decarboxylase NirH subunit
- Protein NirF
- Dihydro-heme d1 dehydrogenase
- Siroheme decarboxylase NirL subunit
- Siroheme decarboxylase NirG subunit
- Nitrite reductase
- Cytochrome c55X
- Siroheme decarboxylase NirD subunit
- uroporphyrinogen-III C-methyltransferase
- Cytochrome c-551
Sequence:
MLRISHYLRSLTEDAPTPRRAGGRRAPVVIWNLLRRCNLTCKHCYSTSADSDFRGELETAEILRGIDDLRAAGVRVLILSGGEPLMHPDLFEIAAHARQAGMFVALSSNGTLIDEGNIQRVAEARFDYVGISLDGLRETHDRFRQKQGSFDAALAAMRLCREADIRVGMRTTLTEENAAQLPALLDLMRELDVQKFYLSHLNYSGRGRRSRALDAHHRRTREALALLFERADQDIRQGRDSDFVTGNNDADAILLLDWLKRRRPQQLARLCELLLDWGGNASGEGIANIDNTGEVHPDSYWWHHSVGNIRHQRFADFWFERPDPLLLQLRQRPRPVVGRCSQCRWLDICNGNTRTRAWAGGELWGEDPGCYLSDQEIGLERIALHAV
Protein: Dpr-interacting protein beta, isoform D (Dpr-interacting protein beta, isoform E) (RE23430p) (Q9VRI6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMNLLVVKESGERIADISCSQEHTTKFSPKLSQVAKHRKLAQLEIASGSGLVGLGTGTGTGSGCGPAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVCIGFKRSVEFSTSVPFRLVPVRFVSFQLLSFCPRSLSFCLICHFKCTICI
Protein: Protein KAKU4 (Q949W6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for nucleus structure organization (e.g. size and shape).
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:24824484}.
Interaction partners:
- Protein CROWDED NUCLEI 4
- Protein CROWDED NUCLEI 1
- Protein CROWDED NUCLEI 2
- Nuclear envelope-associated protein 1
- SUN domain-containing protein 3
- SUN domain-containing protein 1
- WPP domain-interacting tail-anchored protein 1
- SUN domain-containing protein 2
- SUN domain-containing protein 4
- Nuclear envelope-associated protein 3
Sequence:
MDSVSGYAAGAGQPRVGGKIVRPRRTAVVRTPCERPVQRSRDPPQQNPSWISRLVYKPASVIASGAGKFISSVVFSDSSSSSEEDEDSSSDIDGDEDVEKNNPDFTEEDLLSAQQPSIQRLSSKRVIEQLLLQETFAREEGDRLIDIIKARVVDHPSVPSAIETSHDDYGLTSDVNVGEMSNTAVMEARKWLEEKKSGSSSKYKATEDGAGSPVDVAKSYMRARLPWGSPAANNLDFRSPSSARVQGTPLPYSAGNFSSSKLKRKSGSNQSWNIQDEIRKVRAKATEEMLKSPSSVASLEPKYSPYVLATDMLKGNASSLNADGAVRNEQSRALPNSAIPTSEHNQTTEANQAVKETGVLHTRSRGVGLEETFISTQGVKPSEDTNTAPQSGTAVDDFNDQDGDFIQPTSTIGNTTNAVLALGATLDPTGNSCIPKDVFETSKEADEIGASRHTSNGFPSSSPSGYGRSTKTHTTRRNQGFSAYS
Protein: Meiotically up-regulated gene 162 protein (Q9UTP5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MDDEVYKQRLTALNNLRIVIFFDILIILLGYIGTWNLKTLQLVNPSLWSFSPSLWIYIRGTVLCADCIFTAGSANEYSAVQNSVFQVSSLMFYGLMMEFFGYSFDRVGCMELAFISFSAACYFNIRSIKSLSLKNKNWTIISIIEIPIKLHFILNVLLFLKFSEYMLPLLGRVHLSYHLFALWVINLYIWIKLIDSKDFVLGFLAGLSVLLLNTGSLITAKPLISYFNLLTSCLIIFPSIWIYAIEKKNFKNLSYEDDDYRNYW
Protein: Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (D3ZTD1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR038175}.
Interaction partners:
- TNF receptor-associated factor
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- TNF receptor-associated factor
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- TNF receptor-associated factor 6
- NF-kappa-B essential modulator
- Lymphotoxin B receptor)
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Mitogen-activated protein kinase kinase kinase 8
- Mitogen-activated protein kinase kinase kinase 7
Sequence:
MAVMEVACPGTPGSAVGQQKEFAKAKEKTQSPGKKQSCIFQLEAVEKSPVFCGKWEILNDVITKGTAKEGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMARVCRKGKRHSKARKKRRKRRSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLKGPGLGHLCFKKQDEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQATGPLPHPTHPFPFSRMPHPFPFYPLEPWRPYTLNPAFLDKLAAVSGQRPLPGPPHLSKPAYRDSQKPLPGPHLESSCLSREALEKVPAEEYLVHALQGSVSSGQAHSLASLAKTWSSGSSKLQRFSPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRAEELIACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQKGCLPEDRALYYLGQALEGLEYLHTHRVLHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPVREIPPSCTPLTAQAIQEGLRKEPIHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRPPPQDQAPCPQTLHTLPRENPPAKANTDGAPERQPPLPPEPPEPNKAPALNLSKEESGTWEPLPLSSLDPAPAKGPSLPDRRATFPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSEDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSCSMALARGRPTDIPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVCYDMEVPDSGIDLQCTLAPDGSFAWAWRVKHGQLENRP
Protein: Sm domain-containing protein (D6XJG9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVEASRPTRSQDPLPAAVIREFLEMHQQCNDQSLGQGESPTGTEKDGTRAAEARVVSAPLRVEVETTHGYVYEGRLVAMDEFYNVTLTEATKRRERLCDVERSLLTMHGFPAPAASPSTRREYVGSVLVRSGNLLMIRFPQGEGNATRVLHGAFKSMVMKVRRQINLERQKNRMERRRRKQLPVKPQSLVGKAGDPPKRTKAKKE
Protein: Kelch-like protein 31 (Kelch repeat and BTB domain-containing protein 1) (Kelch-like protein KLHL) (Q8BWA5)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (By similarity).
Interaction partners:
- Cullin-3
Sequence:
MAPKKKTIKKNKAEINEMTIIVEDSPLSKLNALNGLLEGSNSLSCVSSELTDTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQKRVKHAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLITVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYIGSAYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMGGSQLGPRGERVDVLTVESFSPAARQWSFVAPLPVGVSTAGVSALHGRAYLLGGWNEGDKKYKKCIQCFNPELNEWTEDDELPEATVGVSCCTLAMPNSVSRESRASSVSSVPVSI
Protein: Interactor of constitutive active ROPs 5 (Protein MICROTUBULE DEPLETION DOMAIN 1) (ROP-interactive partner 3) (Q8VYU8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ROP effector binding specifically activated ROPs and linking them to the microtubule cytoskeleton. Involved in ROP-regulated polar growth. Involved in local disassembly of cortical microtubules when associated with ARAC10 and KIN13A and conversely mediates also the elimination of ARAC10 from the plasma membrane by the cortical microtubules. Accumulates at the plus end of shrinking microtubules. Targets KIN13A to microtubules.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20619818, ECO:0000269|PubMed:22984069}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20619818, ECO:0000269|PubMed:20832900, ECO:0000269|PubMed:22984069}. Note=In xylem cells, preferentially colocalizes with cortical microtubules located beneath the secondary wall pits (PubMed:20619818). May be associated to the plasma membrane through the interaction with ARAC10 (PubMed:22984069). {ECO:0000269|PubMed:20619818, ECO:0000269|PubMed:22984069}.
Interaction partners:
- Kinesin-like protein KIN-13A
- Rac-like GTP-binding protein ARAC10
- Rho GTPase-activating protein 3
- Rop guanine nucleotide exchange factor 4
- Rac-like GTP-binding protein ARAC4
- Protein IQ-DOMAIN 13
- 50S ribosomal protein L11-like
- Rac-like GTP-binding protein ARAC3
- CRIB domain-containing protein RIC4
- Large ribosomal subunit protein uL11y
Sequence:
MQTPKSRPGSLELPQKKSPLPAPKVVRRLKPSGAESDPKTKTISKTQIPKVVADRRSARIPLNEIQKKRTGRIPELESTISQLQEELKKAKEELNRSEALKREAQEEAEDAKHQLMDINASEDSRIEELRKLSQERDKTWQSELEAMQRQHGMDSTALSSAINEVQKLKSKLFESESELEQSKYEVRSLEKLVRQLEEERVNSRDSSSSMEVEELKEAMNLSRQEITQLKSAVEAAETRYQEEYIQSTLQIRSAYEQTEAVKSRYSQREAELTEELNRTKDEIEGLRKELMEKVKEDESTGDLKKLESDLMEVRGSLMDKEMELQILRSAMEKKVETANTEAMEAELKRVKIQCEQWRKAAETAASILNNDEERTDSIETSKMLKKFGVLLKKNHK
Protein: Uncharacterized protein (Q54Y53)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Homeobox protein Wariai
- DNA helicase
- Expansin-like protein 1
Sequence:
MYYRKFVFLLLTLCVFGQSFVQSRTVTLDGTSCGKCQLESMISSLAGGALSSLDDVVIKGVPNAVYTIAKPVLCRAMNITSGTVNLASTIDLRGNLWIASGASMIITGAIKSVSNVFVTVDGIVTVRGGASLIANLNVNGKLNIEAGSLTVNGFIASATALPIVSGAGQLINNGKCIYNAVPTILGTGQFIVNGATQLSKGITCQDKAILSIASKATVDILANSIFAAPIAIASNAEIKLTSGNHVFNGVNGATNSIMTIVNGAVSLNAPSTCHTVDLTGAGSILVNSNSVINTIKAAATAQVNVAKAGLLNINGIADIKAILNLKDTANVVVAAKATANLLGGVNAIAQSQIQAMDSSILNMGKTCTLSQPIIMGKQAVMNAMEGTHSWTQGITSQVNSIINIGSKSNIIANKDCKFGILNLATGSNVNINSGTTIVQGALTTASNSALAVTNAVLNLKATSVIKSALSINAQAKAIFDSKVDLLAGITTHIDSTIDINHNVNILASSTIKSVTNLNANGLLVFGGSKGVSHSCSGDITSDAKSTLNVVAGAILHLDGDAVLAGTHKLVDGSQIIVNGNANIISGLTSTGSALSHFTVGPTGSCVLGNTPMPTLPSFPTIPGFPSFPSASQKSWSHHGHSNNGNNGNNGNNGNNGNNGNNGNNGNNGNNNGNNGNNGNNGNNGNNGNNGNNGNNGNNGNNGNNGNNGNNGQSSGSNQMPSSTISFPSSGSASSGSFPSSSTGSNQMPSSTISFPSSGSASSGSFPSSGSASSGSFPSSGSSNNGQTSGKSTTTTTTTSSSSSSSSITNINGNVIIQTGGSLDVLGKCNVGSTVQNLGSLTLTQPMVIAGNAFTQTSATAVLNMVAGGSIESKVIDFTHGTIQGVGALKCGTCNFANKIAANLNIVGNVKMAATATVYANIDALMSITTSTQTSISQSSTKTVNGKTTTQSSSSSSSSISKQFVPMIVCSGTADVAGNLNVVASEANQAKIASGTVFKFISAPVVKGNVSSVSCLTSSTAAAAQQAAGAAAAAAQKAAMAAASKVWSIVNSPCNCECGLKRL
Protein: Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) (O75864)
Organism: Homo sapiens (Human)
Function: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sequence:
MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETL
Protein: Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) (P15531)
Organism: Homo sapiens (Human)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Interaction partners:
- Nucleoside diphosphate kinase B
- Nucleoside diphosphate kinase 3
- Nucleoside diphosphate kinase, mitochondrial
- DNA repair nuclease/redox regulator APEX1
- Nucleoside diphosphate kinase
- Acidic leucine-rich nuclear phosphoprotein 32 family member A
- Rho guanine nucleotide exchange factor TIAM1
- Thymidylate kinase
- Inosine triphosphate pyrophosphatase
- CTP synthase 1
Sequence:
MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
Protein: NAC domain-containing protein 18 (ANAC018) (Protein NAC-REGULATED SEED MORPHOLOGY 2) (Protein NO APICAL MERISTEM) (AtNAM) (Q9ZNU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May encode a transcription factor involved in the elaboration of shoot apical meristems (SAM) (Probable). Together with NAC056/NARS1, regulates embryogenesis by regulating the development and degeneration of ovule integuments, a process required for intertissue communication between the embryo and the maternal integument.
Subcellular location: Nucleus {ECO:0000269|PubMed:18849494}.
Interaction partners:
- glucan endo-1,3-beta-D-glucosidase
Sequence:
MESTDSSGGPPPPQPNLPPGFRFHPTDEELVIHYLKRKADSVPLPVAIIADVDLYKFDPWELPAKASFGEQEWYFFSPRDRKYPNGARPNRAATSGYWKATGTDKPVISTGGGGSKKVGVKKALVFYSGKPPKGVKSDWIMHEYRLTDNKPTHICDFGNKKNSLRLDDWVLCRIYKKNNSTASRHHHHLHHIHLDNDHHRHDMMIDDDRFRHVPPGLHFPAIFSDNNDPTAIYDGGGGGYGGGSYSMNHCFASGSKQEQLFPPVMMMTSLNQDSGIGSSSSPSKRFNGGGVGDCSTSMAATPLMQNQGGIYQLPGLNWYS
Protein: Carboxynorspermidine/carboxyspermidine decarboxylase (CANS DC/CAS DC) (CANSDC/CASDC) (EC 4.1.1.96) (C6YCI2)
Organism: Vibrio cholerae (strain MO10)
Function: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine. Involved in the regulation of biofilm formation and motility.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
METLQDIGTNMLKDELRTPYFMIDEAKLIANLEIAKHLKEISGVKMVLALKCFSTWGVFDIIKPYLDGTTSSGPFEVKLGYETFGGETHAYSVGYSEEDVKEVIDICDKMIFNSQSQLAAYRHLVEGKASLGLRINPGVSYAGQDLANPARQFSRLGVQADHIDESVFDSINGVMFHMNCENKDVDAFIGLLDAISERFGRYLDKLDWVSLGGGVFFTWPGYDVEKLGAALKAFAERHAVQLYLEPGEAIITKTTDLVVTVVDIVENGMKTAIVDSATEAHRLDTLIYKEPASVLEASDKGQHEYVIGSCSCLAGDQFCVAKFDEPLQVGQKLHILDSAGYTMVKLNWFNGLKMPSVYCERKNGQIQKINQFGYEDFKRTLSLWSIE
Protein: Prolactin (PRL) (P01239)
Organism: Bos taurus (Bovine)
Function: Prolactin acts primarily on the mammary gland by promoting lactation.
Subcellular location: Secreted.
Interaction partners:
- Prolactin receptor
- Growth hormone receptor
- Insulin
- Tyrosine-protein kinase
- Somatotropin
- Thyrotropin subunit beta
- Pro-opiomelanocortin
- Oxytocin-neurophysin 1
- Pro-thyrotropin-releasing hormone
- Leptin receptor
Sequence:
MDSKGSSQKGSRLLLLLVVSNLLLCQGVVSTPVCPNGPGNCQVSLRDLFDRAVMVSHYIHDLSSEMFNEFDKRYAQGKGFITMALNSCHTSSLPTPEDKEQAQQTHHEVLMSLILGLLRSWNDPLYHLVTEVRGMKGAPDAILSRAIEIEEENKRLLEGMEMIFGQVIPGAKETEPYPVWSGLPSLQTKDEDARYSAFYNLLHCLRRDSSKIDTYLKLLNCRIIYNNNC
Protein: Tropomyosin (Q02088)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Forms part of the F-actin contractile ring during cytokinesis.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Actin
- Fimbrin
- Myosin type-2 heavy chain 1
- Cofilin
- Alpha-actinin-like protein 1
- Profilin
- Myosin type-2 heavy chain 2
- Cell division control protein 12
- Myosin regulatory light chain 1
- Myosin-51
Sequence:
MDKLREKINAARAETDEAVARAEAAEAKLKEVELQLSLKEQEYESLSRKSEAAESQLEELEEETKQLRLKADNEDIQKTEAEQLSRKVELLEEELETNDKLLRETTEKMRQTDVKAEHFERRVQSLERERDDMEQKLEEMTDKYTKVKAELDEVHQALEDL
Protein: Prefoldin subunit 2 (Q9UHV9)
Organism: Homo sapiens (Human)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.
Interaction partners:
- p53 and DNA damage-regulated protein 1
- Prefoldin subunit 5
- Prefoldin subunit 1
- Prefoldin subunit 3
- Prefoldin subunit 4
- Prefoldin subunit 6
- Protein UXT
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Unconventional prefoldin RPB5 interactor 1
- Dynein axonemal assembly factor 10
Sequence:
MAENSGRAGKSSGSGAGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQIQKIIETLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS
Protein: GH11992p (Q8IH55)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
IFLALFVLSKSDTGAGEDSEEDDENDCNRTTLGGHPVNITTAPWIASISIKQKAKCDGAIYKLSHIVTAGKCVDGFLNKVIRVRVGSTTRSDGVIEVAVCNITVHEKFTGQTVFHNVAILKLCEPLEASKTIQPIQLANQLPSNGAKVTANGWPSFRWWAMYWKKCLDDEAYKLQKAEVKLLGPSQCTDLWARNNWSKKNFTDDLFCTEKFAKEACSLAMGSPVVHNGKLVGIITKGGCSEYPEVYINLIKYKDWLHNHTK
Protein: Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6C isoform X1 (Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6C precursor) (Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E) (Semaphorin 6E) (E3W9A6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRLVILGSRPLLALTLMLTLTCLKHLCHGATPFPQDLEPIRTVGSEHTYLYPSFQGNMSDNDTARLGLDFQRMLRINHMVYIAARDHVFAINLSASLERIVPQQKLTWKTKDVEKCTVRGKNSDECYNYIKVLVPRNDETLFACGTNAFNPTCRNYKMSSLEQDGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGESSPVLRTVKYDSKWLREPHFLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDSFFYFDVLQSLTNVMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPDEAVPKPRPGSCAGDGPAAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFKLTQIAVDTAAGPYKNYTVVFLGSENGHVLKVLASMHPNSSYSTQVLEDIDVYNPNKCNVRGEDRRILGLELDKDHHALFVAFTGCVIRVPLSRCSDYGICRKSCLSSRDPYCIWLSAGNCATVAPGFKSGFEQYVESGYPQYPDSCHDVLATTRKQNPAVDSAYGKTSPTSASTTNQGPAGAPETGTHPEEGRRGGQGSPDLEPGSVEMEGVRRPPEVDKSNHSVHYTLLIACVLVAFVLGAFLSGFLVSCYCNHNVNKTKRLSKDPEAPIPHALSLRSLAKLNGLLESQNKDEKLEVSSPKLYNSFFANGKEQAHRRNAHHAAMTELIHPHHHHSAELSGLPTPDSTPELPIKSMKAFKNQWEKNQNCNNAKEPKSHNMGASRPTSAMQHQMFPFSHGLTNGQVLGGSVHMDERKVHNTERVVSQPYHCYPHKIVDVTSLDELLKHIHEINVATGKSPSVLTSSMSANAGQMAFANRVQPHIPETESAPYYSSSTLPRDSLTRRMDIPPEIPPHHQSTLERVSRHPAQRHSLITTPKMPSGGVVPRQHSFNQRSSHQPLLLSRMNSNGSNSGCDVRHPLIPNGYLTRQHSYSEQPEVHRGAIVRRTASLKPDVPPKPLFIPASSPVNQAGKFNY
Protein: Maestro heat-like repeat-containing protein family member 2B (HEAT repeat-containing protein 7B2) (Sperm PKA-interacting factor) (SPIF) (Q7M6Y6)
Organism: Mus musculus (Mouse)
Function: May play a role in the process of sperm capacitation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27105888}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27105888}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:27105888}. Note=Colocalizes with PRKACA and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000269|PubMed:27105888}.
Interaction partners:
Sequence:
MEEYGDMFGDINLTIGMLSKEDNISKEDIYCHLTSFIQNTDIMDDAIVQRLIYYTSKDMRDEEIPRELRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPNEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLVEDENMRQTFCIALENFSKSIYKYVNHWKDFPYPKLDANRLSDKIFMLFRYIMEKWAPQASPMHALAIIKAHGPTVSLLLHREDFCEFALSQISWLLLQYRDKENDFYITQSLKQILTAAVLYDIALPKNLRRSVLSSLLHQICKVPEPPIKENKLEASSCFLILAHANPVDLLDFFDEQIRSTNEAVRTGILTLLRSTINAEEPKFRNHTTSIEKTVKLVMGDLSVKVRKSTLLLIQTMCEKGYIEAREGWPLIDYIFSQFAMSNRNLENPIKSNSQEDENGEKSVQETSLEVLKSLDPLVIGMPQVLWPRILTYVVPKEYTGTLDYLFNIIRILIMAEEKKKRDIQESTALVVSTGAVKLPSPQQLLARLLVISILASLGQLCGAGAIGLLKIMPEIIHPKLAEMWKTRMPALLQPLEGSNASIVLWETMLLQLLKESLWKISDVAWTSQLSRDFSLQMGSYSNSSMEKKFLWKALGTTLASCQDKDFVSSQINEFLVTPSLLGDHRQGTTSILGFCAENHLDIVLNVLKTFQDKEKFFVNRCKGIFSGKKSLTKTDLILIYGAVALHAPKQQLLARLDQDIMGQILLLYGQCCQILGVSVINKDMDLQMSFTRSITEVGIAVQDAEDQKFQFTYKEMLIGSMLDLIKDEPLNTLASPVRWKVLIAIRYLSKLKPALSLNDHLNILEENIRRLLPLPPLEKLKSQGETDKDRERIEFLYERSMDALGKLLRSMIWDNTDAQNCEEMFNLLRMWLVSQKQWERERAFQVTSKVLTKDVEAPQNFRIGSLLGLLAPHSCDTLPTIRQAATSSTIGLLCAKGICQEVDRLQGLQEGLDSEDEQVQIKISSKIAKIVCKFIPSEEIQVFLEETLDGLETLDPLCTKACGIWMIAALKEHGALLEDQLLEILSTIYHHMPVLRQKEESFQFMLEAISQIASFHMDAVVNNLLQKPLPFDRDTKTLWKALAENPASSGKLMRALIKKLVARLEDDIAGTEAISVACAIYEVILTGAHITHLYPELFTLLLKLVSCSLGQKMPMSTLSQRRRVMQLGERQRFPDPCRLSTATLKCLQAQAMREGLAKESDEGDNLWTLLSNPDTHHIGVCALARSMAVWQHGVILDIMEHLLSSLTSSSENYRITGMAFFSELMKEPILWKHGNLRDVLIFMDQNARDSNAILRQMAIRGLGNTACGAPHKVRKYKQMMLECIIRGLYHLARTEVVCESLKALKKILELLTERDINFYFKEIVLQTRTFFEDEQDDVRLTAISLFEDLATLTGRRWKIFFAEEVKKSMISFLLHLWDPNPKIGAACRDVLVICIPFLGLQELYGLLDHLLERDLPRARDFYRQLCMKLSKKNQEILWILHTHSFTFFTSSWEMIRSAAVKLTDAIILHLTKRYVELLDREQLTMRLQALRQDPCISVQRAAEATLQTLLRRCKEISIPL
Protein: E2F transcription factor 5 (E5RHD4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKTSVIALMVSDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILNY
Protein: RDS3 complex subunit 10 (Splicing factor 3b subunit) (P0C074)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. Required for the SF3b integrity and prespliceosome assembly.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-processing ATP-dependent RNA helicase PRP5
- Cold sensitive U2 snRNA suppressor 1
- U2 small nuclear ribonucleoprotein A'
- Protein HSH49
- U2 snRNP component HSH155
- Pre-mRNA-splicing factor PRP11
- Pre-mRNA-splicing factor PRP21
- Pre-mRNA-splicing factor BUD31
- 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor RDS3
Sequence:
MAEKQRQLKLQKIYKQKYIGLGDESTTREQWQRNVRNDTLNTLQGHSASLEYVSLSRGDLSIRDTRIHLLKSMSPGYKAYLREER