wanglab/gogpt-training-data huggingface dataset:
Protein: Pre-mRNA-processing factor 17 (Cell division control protein 40) (P40968)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May function in the second step of pre-mRNA splicing. Regulatory protein involved in replication and mitotic spindle formation and/or maintenance. Required for initiation and completion of S-phase and for initiation and completion of DNA replication. Might be required for the maintenance of microtubules. Essential only at elevated temperatures.
Subcellular location: Nucleus.
Interaction partners:
- Pre-mRNA-splicing helicase BRR2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22
- Pre-mRNA-splicing factor BUD31
- Splicing factor YJU2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-splicing factor 8
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-splicing factor SLU7
Sequence:
MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD
Protein: Protein NSP-INTERACTING KINASE 2 (EC 2.7.11.1) (LRR receptor-like serine/threonine-protein kinase NIK2) (Q8RY65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in defense response to geminivirus infection (By similarity). Phosphorylates RPL10A in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15489295}; Single-pass type I membrane protein {ECO:0000269|PubMed:15489295}.
Interaction partners:
- L10-interacting MYB domain-containing protein
- Large ribosomal subunit protein uL10c
- Small ribosomal subunit protein eS25y
Sequence:
MLQGRREAKKSYALFSSTFFFFFICFLSSSSAELTDKGVNFEVVALIGIKSSLTDPHGVLMNWDDTAVDPCSWNMITCSDGFVIRLEAPSQNLSGTLSSSIGNLTNLQTVLLQNNYITGNIPHEIGKLMKLKTLDLSTNNFTGQIPFTLSYSKNLQYLRVNNNSLTGTIPSSLANMTQLTFLDLSYNNLSGPVPRSLAKTFNVMGNSQICPTGTEKDCNGTQPKPMSITLNSSQNKSSDGGTKNRKIAVVFGVSLTCVCLLIIGFGFLLWWRRRHNKQVLFFDINEQNKEEMCLGNLRRFNFKELQSATSNFSSKNLVGKGGFGNVYKGCLHDGSIIAVKRLKDINNGGGEVQFQTELEMISLAVHRNLLRLYGFCTTSSERLLVYPYMSNGSVASRLKAKPVLDWGTRKRIALGAGRGLLYLHEQCDPKIIHRDVKAANILLDDYFEAVVGDFGLAKLLDHEESHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGLRALEFGKAANQRGAILDWVKKLQQEKKLEQIVDKDLKSNYDRIEVEEMVQVALLCTQYLPIHRPKMSEVVRMLEGDGLVEKWEASSQRAETNRSYSKPNEFSSSERYSDLTDDSSVLVQAMELSGPR
Protein: Uncharacterized protein (Q383Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
Sequence:
MQQQNRTEIVQDITNAVKLEQELRLIHEQHGVAVLDVYSSEWGLSKALSETFRRLQMDASDQAYLRFLSVECNSILESIDQTEEHHQHMKTDDKVKFRESLAPFWKDILESRRGKSKSYFVFFKEGRKRTSIEGINTPKIINYVIELCRSQKPAKECTESKPLLDFWGRYFGEGESEVFWESFMRAILEHVGTARPLSAKEESTLAEVIGVDGDKVSVSALDKWTAGQAIETAFINVFPFLSKSEETPADSGKRKASGDQPADDTALTGSFVNVLSSHCDARTEWKPEIWHRVLAIQPDGSGNSRFVLMSCEEAEKDAEDALALVADLPTVEAYLSGCNVAAENIHIMCHAAAEKYPSGSIAYAKLAQLLISCNGDKLEELTGVRQELADELAGGTLLKNYPTLAYTVICHCTSEVTDAKPFYYCCDEAGQVNQIENAKEGGQVVLPPLSRLSSSGETEAAFKVEICGIPNVIQLEETGENGVFTVLTPWFTKFNVKEASDNHLVLEFVENVGDEQFRQVLEPYAKRICEDEDKLSASADIIALYERSLGLGHELSLPSVATQNNFGGSGAPPSASSVGRMRSTSGVEAPKGEHAEGAPGGSASRLHEGSTSQHSRSAVENGAGGEGDVEVEEGQVTEPPIAQDTVAAEDAVADGGANADEEGAAQEVANEEYADEQFGDEQSCEAGKPSDTEDANEKTSEAAKEEDAEEIGSKQASEAAKDPDTGDIEGNEASGAAKEAETEEIGSKQISETAKEADTEEIDSEWTSEARKPSDTEDANEKTSEAAKDPDNDDTESKQTSEAAKVDAEEIGSDQASEAMKRSGTEGASERTSEAAKDPDTEDTESKQTSEAAKVDAEEIGSDQASEAMKRSGTEDISGRGSEGSRD
Protein: Orf6 protein (Q37990)
Organism: Streptococcus phage Cp-1 (Bacteriophage Cp-1)
Interaction partners:
Sequence:
MKQPLKSEKQTILFDGFILSVYRSFFKNLLHKQQVKNKKGYYYQKSNNAPKNTIFLKSYLKAHYAYEDFDYIMELYKFVSQEFDKISINAFYNLCNYLEENKIYSLSSNALYDCYEKSKNRQNDLENLNTIITPLKFLKSTNGDKQNG
Protein: Mating-type-like protein A1 (MTLa1 protein) (Q9UW23)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Rme1p
- Mating-type-like protein A2
- Cup9p
- White-opaque regulator 1
- Uncharacterized protein
- Oxysterol-binding protein-like protein OBPa
- ATP-binding cassette alpha-factor transporter
- Alpha-factor pheromone receptor
Sequence:
MNSEIESSLTLLKSVEKLVQATSVYKNEDNEEIFLQLKRERQENSNSHEETETLFHESLDRLMKLSSIAGSKVQYELSLNNLYNLLLRTRKQEEEEAFIFPTVSTEEFALEQITFEVSDQMDDDKDSEDDILIKGEEIKKSKKKRQRLDNSTKEFLEKVFEKNKQPNRRERELIAEKHGVSLSQIRVWFTNKRMRKKEPKSKAKSSSNST
Protein: UMP-CMP kinase 3 (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (O04905)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Does not act on dCMP and dUMP.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03172}.
Interaction partners:
- Uridine 5'-monophosphate synthase
- UMP kinase
- Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
- Nucleoside diphosphate kinase 1
- Nucleoside diphosphate kinase II, chloroplastic
- Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
- Ribonucleoside-diphosphate reductase small chain C
- Ribonucleoside-diphosphate reductase small chain A
- Uracil phosphoribosyltransferase, chloroplastic
- Ribonucleoside-diphosphate reductase large subunit
Sequence:
MGSVDAANGSGKKPTVIFVLGGPGSGKGTQCAYIVEHYGYTHLSAGDLLRAEIKSGSENGTMIQNMIKEGKIVPSEVTIKLLQKAIQENGNDKFLIDGFPRNEENRAAFEKVTEIEPKFVLFFDCPEEEMEKRLLGRNQGREDDNIETIRKRFKVFLESSLPVIHYYEAKGKVRKINAAKPIEAVFEEVKAIFSPEAEKVEA
Protein: Myeloid cell nuclear differentiation antigen-like protein (D0QMC3)
Organism: Mus musculus (Mouse)
Function: Suppresses cell growth when expressed ectopically.
Subcellular location: Nucleus {ECO:0000269|PubMed:19654412}.
Interaction partners:
- Interferon activated gene 203
Sequence:
MAEYKKIVLLKGLESMEDYQFRTVKSLLRKELKLTKKLQEDYDRIQLADWMEDKFPKYAGLDKLIKVCEHIKDLKDLAKKLKTEKAKVQKKKQGKCKTAVKKKGQDELSSSESLFINKESYKSVPSSKKKGKAIAKTEGEKKNKLTQDQDHLPETSGTDIKTEEDCLQNSPKPPPTSPSSSSNKKKRKEITKTEGGKKKKLTQEQAQLPEPLGTDIKKDEDCLQTPPKPPPTPPSSSLNKKRKSRREEETGVKKSKAAKEPDQPPCCEEPTARCQSPILHSSSSASSNIPSATNQKPQPQNQNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMFHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLKADPDQMIEVPNNIIRNANASPKICDIQKGTSGAVFYGVFTLHKKKVKTQNTSYEIKDGSGSIEVEGSGQWHNINCKEGDKLHLFCFHLKRERGQPKLVCGDHSFVKIKVTKAGKKKEASTVLSSTKNEEENNYPKDGIKVEMPDYHV
Protein: Large ribosomal subunit protein bL27 (50S ribosomal protein L27) (O67650)
Organism: Aquifex aeolicus (strain VF5)
Interaction partners:
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein bL19
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein bL17
Sequence:
MASKASGGSTRNGRDSISKRLGVKRYDGQFVKAGNIIVRQRGTRIYPGKNVGMGSDYTLFALKDGYVYFETRRKKKFVSVLSPEEWEKVMAQKNGKVH
Protein: Exopolyphosphatase (EC 3.6.1.11, EC 3.6.1.40) (Q8NRR8)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Uncharacterized ACR
- Exopolyphosphatase
- Septum formation initiator
- GTP pyrophosphokinase
- 3-dehydroquinate synthase
- Uncharacterized BCR
- Subtilisin-like serine proteases
Sequence:
MTRYAAIDCGTNSIRLLITEVTPEGFKEITRENTIVRLGKGVDATGQLDPEAIERTRVALENYVELMETHGVEAVRMVATSATRDASNRDEFFSMTRQLLSKIRPGYQAEVISGEEEALLSFRGAIVDLPEDQGPFCVIDLGGGSTEFIVGTYDGEILGSHSTQMGCVRLTERIMRSDPPTETEVEIARDYVAERIQEVKAIVPISKAKTFVGCAGTFTTISAWVQGLESYDRDAIHLSALNFDALRVVTDEIISESSSQRASNPVVDPGRADVIGGGSVVVQAAIDLASKEAGVDYIIISEKDILDGLILGLVEADSLKK
Protein: C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) (Q86YS7)
Organism: Homo sapiens (Human)
Function: Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21907143}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21907143}. Cell membrane {ECO:0000269|PubMed:21907143}. Cell projection, ruffle {ECO:0000269|PubMed:21907143}. Note=Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation.
Interaction partners:
- Acidic fibroblast growth factor intracellular-binding protein
- Cyclin-dependent kinase 5
- RAC-beta serine/threonine-protein kinase
Sequence:
MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVDDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAATVISGWFPIYDTIHGIRGEINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVIIHGFVEELVVNEDPEYQWIDRIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAAFLPACNSPSKEMKEIPFNEDPNPNTHSSGPSTPLKNQTYSFSPSKSYSRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKAMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQCLINVSGDAVVFVRESDLEVVSSQQPTTNCQSSCTEGEVTT
Protein: RNA polymerase sigma-D factor (Sigma-28) (P10726)
Organism: Bacillus subtilis (strain 168)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. This alternative sigma factor is required for the transcription of the flagellin and motility genes as well as for wild-type chemotaxis. Associates with the RNAP core during all growth phases with a peak at the transition to stationary phase.
Interaction partners:
- Negative regulator of flagellin synthesis
- Flagellar basal body rod protein FlgB
- Flagellar motor switch protein FliM
- Flagellin
- Flagellar biosynthesis protein FlhA
- Flagellar basal-body rod protein FlgG
- Flagellar motor switch phosphatase FliY
- Flagellar motor switch protein FliG
- Flagellar biosynthetic protein FliQ
- Flagellar M-ring protein
Sequence:
MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISVGLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPRTSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEKLHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEELTLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ
Protein: PMS1 postmeiotic segregation increased 1 (S. cerevisiae) (Q6P7D0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGANSIDVKLENYGFDKIEIRDNGAGIKAVDVPVMAVKYYTSKISSHEDLQTLTTYGFRGEALGAICNVAEVVVTTRTAADDFSTQYVLDGSGHILSQKPSHLGQGTTVTVLKLFKNLPVRRQFYSTPKKCKDELKNVQDLLISYAVLKPDLRITFVHNKAVIWQKSRVPDHRMALMSVLGTAVMGNMESVERYCEDSQIHLRGLFPKHDADHNSTSLSTPERSFIFINSRPVHQKDILKLIRHYYNLKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLLMTCYGPLPTTESYENNRVDVSSANVVISETTETDVLFNKMESSGNKYPNADTLAIPFQNDESRKNTDHHLNEQINIGHCDGHFSGEYSHINKDTFQNIPRNNLSSEANQSKHSETHSADSIEHIQGENGRSGTGENGEDGKKTLPEKALEICADDWSKGNVFNSMGENIEPVKILVPQKSLSCKVTNSHPNPEPENLSVGPGSRTSNVIDNRPGQLTAYDLISSRAVKKPMSACALFIQDHRTQFLAENPKTGLEDVTAQIKAQWETLSEEEKHKYEEKAKKDLERYNNQMKKAIEQEAQVSLKDGRKKLRATGAWGCTQRHKVKDLSNQPKLDELFQSQNEKKSENIKITKIPFSMENLKVNFNKQKEVDLEEKDEICLIHSLKFPDAWLVTSRADVMLLNPYRVEEALLFKRLLENHKFLAEPLDKPIVLTESLFNGSDYLEVLHKMSTVEERCRGSVYLCDPRLTANGFKIRLTPGVSSAENYLEIEGMAKCLPFYGVMDLKEILNAIVNKNAKEIYECRPRKVINYLEGEAVRLSRQLPMYLPQEDVQDLIYKMKHQFGKEIKGCVHGRPFLHHLIHLPGTS
Protein: WD repeat domain 62, isoform D (A8DYT1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTPASLSASTPTLSTLHHQRMALQSQSQSPLASPLTPSPSSVFGSPKFPANYERSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPGNPKTLNPMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQHRNGNVSRSASKRNSLQGKTGLGASSNSMNVLNQGSDSEPEDSNRLRSASNGQGRSNGPIAANRQYSNKINNVNNNRRKTPNFSSATPMQDDSSSEETPNSTVNNKPIVPPRPRNLAFDHKSKLMINNSGSPGGNAKQRSGVTSTEDFEGTDPEAQVHNVINKLYTTTQAAMQLHANLKNTLLLKELENALIMSRNMLSSITNRQADKTNNGGGGLGVGGSGGLNHDQLNADNGDYLMMVNNCADLLSNLRTKHKPDDCENNS
Protein: Cystathionine gamma-lyase (EC 4.4.1.1) (Gamma-cystathionase) (Homocysteine gamma-lyase) (EC 4.4.1.2) (O05394)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide.
Interaction partners:
- O-acetylserine dependent cystathionine beta-synthase
- Cysteine synthase
- Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase
- Uncharacterized methyltransferase YrrT
- Probable cysteine synthase
- Serine acetyltransferase
- Cystathionine beta-lyase PatB
- Sulfite reductase hemoprotein beta-component
- S-ribosylhomocysteine lyase
- Sulfite reductase flavoprotein alpha-component
Sequence:
MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEYSRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTYRVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIAKKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPGSSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPARMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI
Protein: TRAF-interacting protein with FHA domain-containing protein A (TRAF2-binding protein) (Q793I8)
Organism: Mus musculus (Mouse)
Function: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96CG3}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000250|UniProtKB:Q96CG3}.
Interaction partners:
- TNF receptor-associated factor 6
- Alpha-protein kinase 1
- Interleukin-1 receptor-associated kinase 1
- TNF receptor-associated factor 2
Sequence:
MSTFEDADTEETVTCLQMTIYHPGQQSGIFKSIRFCSKEKFPSIEVVKFGRNSNMCQYTFQDKQVSRIQFVLQPFKQFNSSVLSFEIKNMSKKTSLMVDNQELGYLNKMDLPYKCMLRFGEYQFLLQKEDGESVESFETQFIMSSRPLLQENNWPTQNPIPEDGMYSSYFTHRSSPSEMDENEL
Protein: AT13091p (GM04721p) (Rings lost, isoform A (EC 3.4.23.-)) (Rings lost, isoform B) (Q9VXF9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4
- Ubiquitin-ribosomal protein eS31 fusion protein
- UV excision repair protein RAD23
- Polyubiquitin
- GH17761p
- UV excision repair protein RAD23
- Ubiquitin-like domain-containing protein
Sequence:
MKITVTTSDDKVFCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSSDKQTLQQCGVGDGDFIMLERRRSANRPVGGNPAISTLDFSNIAVPGTSSGGSPPSRRVQQQGVQQPQFNNLTDIPTTDEFNVNFDDDPETVRQMFLSSPETLSLLRQYNPSLAEAIDSGDKEKFARLLREHITERKRRNEHRMRMLNADPFDEETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSGAQTTIMSKDCAERCHVNRLIDTRWNGVAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMDMLLGLDMLKRHQCLIDLQRNLLIIGTTGTTTPFLPESELPVSARLTGNSEDSMEQEAISNAIEQSKRESGGAGGGPNTISPQERFTEQDVTDLMALGYPRSDVLTVLRLCGGNKQAARSVLLHRNDAASGSELS
Protein: AT28918p (GEO08806p1) (Male sterile (2) 35Ci, isoform A) (Male sterile (2) 35Ci, isoform C) (Q8MZ67)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein shuttle craft
- Male sterile
Sequence:
MPIIKKFCYCFSLRIGAFSIAYAGLTMDVLDTVATIYTKSQYCADILLLWIISTIWNIISALVLLTALFRENPHLLPVHLVTSLCGLMLEMTNHMVIASLGRTDYVLISYAFIMIAFVSADVVIVLSYYQSEV
Protein: Neural lazarillo, isoform B (M9PBN2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNHHSSSHLLLLISVVFGAVWVAHAQVPFPGKCPDVKLLDTFDAEAYMGVWYEYAAYPFAFEIGKKCIYANYSLIDNSTVSVVNAAINRFTGQPSNVTGQAKVLGPGQLAVAFYPTQPLTKANYLVLGTDYESYAVVYSCTSVTPLANFKIVWILTRQREPSAEAVDAARKILEDNDVSQAFLIDTVQKNCPRLDGNGTGLAGEDGLDVDDFVSTTVPNAIEKAXEWLRRLYERLYDIFMNFLSY
Protein: Choline/ethanolamine kinase (Choline kinase beta) (CK) (CKB) (EC 2.7.1.32) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (choline/ethanolamine kinase beta) (CKEKB) (O55229)
Organism: Mus musculus (Mouse)
Function: Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
Interaction partners:
- Ethanolamine-phosphate cytidylyltransferase
- Choline-phosphate cytidylyltransferase B
- Choline-phosphate cytidylyltransferase A
- Glycerophosphocholine phosphodiesterase GPCPD1
- Phosphoethanolamine/phosphocholine phosphatase
- Choline O-acetyltransferase
- Choline kinase alpha
- Acetylcholinesterase
- Ethanolamine-phosphate phospho-lyase
Sequence:
MAADGTGVVGGGAVGGGLPKDGLQDAKCPEPIPNRRRASSLSRDAQRRAYQWCREYLGGAWRRARPEELSVCPVSGGLSNLLFRCSLPNHVPSVGGEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYLPSRPLKTQELRDPVLSGAIATRMARFHGMEMPFTKEPRWLFGTMERYLKQIQDLPSTSLPQMNLVEMYSLKDEMNSLRKLLDDTPSPVVFCHNDIQEGNILLLSEPDSDDNLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTYEEWPFYKARPTDYPTREQQLHFIRHYLAEVQKGEILSEEEQKKREEELLLEISRYSLASHFFWGLWSTLQASMSTIEFGYLEYAQSRFQFYFQQKGQLTSSPSS
Protein: Kinesin-like protein KIN-7H (F4JZ68)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cell division cycle 45
Sequence:
MTTEDDDQMLGPSGTQEKIYVSVRMRPLNDKEKFRNDVPDWECINNTTIIYRSHLSISERSMYPSAYTFDRVFSPECCTRQVYEQGAKEVAFSVVSGVNASVFAYGQTSSGKTYTMSGITDCALVDIYGYIDKHKEREFILKFSAMEIYNESVRDLLSTDTSPLRLLDDPEKGTVVEKLTEETLRDWNHFKELLSVCKAQRQIGETALNEVSSRSHQILRLTVESIAREFSTNDKFSTLTATVNFIDLAGSERASQSLSAGTRLKEGCHINRSLLTLGTVIRKLSKEKTGHIPFRDSKLTRILQSSLGGNARTAIICTMSPARIHVEQSRNTLLFASCAKEVTTNAQVNVVMSDKALVKHLQRELAKLESELRSPSQASIVSDTTALLTEKDLEVEKLKKEVFQLAQQLEQARSEIKDLRRMVEEEKNQEKETLSTETEGLNVLMEHQYPKLRVRRTWDSENTTPLSPISAHRSSISPRSTEYSYEENVFQLSDFRIDSASSSPQQLAFVTPFLKVPLDDIHVTDTVDQSHVHKEEAIEEPHVQEERFYEMAEHTDGNSEDNCREVRCIETEKSDISIGPVENMPESSPDKYEAVTAEEPVSVTEPKNLQHPTEEAVCVTETKNLQHPTEAENEEEEEEERVKEVSGASPEPKQESNLTKNPALCDLECSPDEFDTSMSNLSRISTPPALITPSPEKPFSWIMERDSQLFRGMKLTRSRSCRPSLLSSPSSSWLEKDADTPPSWYDKEFIKTAERNLTMCDIKNQRLLQDEFSGRSMPTTWFERSLSDTQTVDAASHGVSNEMSPNESPFRPSDASVFELQTSGRASISQDRTEETAAQKDKQIIHRSMEEREQKFLASNSTKSFKDAAMDPIQDYLDTALNWPVEFKRLQREIIELWHVCKVSMAHRSYFFLLFRGDQKDCLYLEVELRRLKYIRESFAQNSNDGNNMTLISCTRALTRERYKLSKLMQRKLSKEERENLFLRWGIGLNTNHRRVQLARRLWSDYKDMGHVRESASLVGKLNGFVDMKLTSTEMFGVNYAFRPPRPKKSSLWKRSVLSLSFL
Protein: Ran specific GTPase activating protein An-RanGAP (Eurofung) (Q5B3L8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- GTP-binding nuclear protein
- SUMO-conjugating enzyme UBC9
- Nucleoporin NSP1
- Ran-specific GTPase-activating protein 1, putative
- Ubiquitin-like domain-containing protein
- Uncharacterized protein
- Nuclear protein export protein Yrb2, putative
- Nuclear pore complex subunit Nup133, putative
- Exportin 1
- Nuclear pore complex protein
Sequence:
MAPPKIFSLEGKGLKLDSAADIEAHIQPLLESTDYTEVRLGGNTLGVPASERLAAVLSTQKSLEVAELADIFTSRLLSEIPDALTFLLNALLEIPTLHTINLSDNAFGANTQKPLVDFLSRHIPLRHLVLNNNGMGPEAGSNIAKALTELAQRKEEARSGGKEVPLLESIVCGRNRLENGSMAAWAHAYKAHAAGIRSVKMTQNGIRQEGISHLLKEGLSHASALEVLDLQDNTFTITGSTALAGVVSGWPSLRELGVGDCLLSARGGIKLAQALAKAKNQKVEILRLQYNDISAEGVKQFLHAAKTALPALRRIELNGNKFQEEDVNVTELSELLESRKEAHGKDDDPEDMWGIDELDELESEDEEEEEEEEEEEEEEQKAEKVVKDAEIAENEKVAQAQDNDVDKLAEAFGKTGI
Protein: Ubiquitin-like-specific protease 1A (EC 3.4.22.-) (Q8GYL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, and very inefficiently of SUM3. Seems to be the only ULP1 able to cleave SUM3 precursors. Cleaves SUMO peptides better than SUMO-conjugated proteins.
Interaction partners:
- Cysteine proteinases superfamily protein
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 2
- SUMO-conjugating enzyme SCE1
- SUMO-activating enzyme subunit 2
- Small ubiquitin-related modifier 3
- Small ubiquitin-related modifier 5
- E4 SUMO-protein ligase PIAL1
- Putative small ubiquitin-related modifier 4
- SUMO-activating enzyme subunit 1A
Sequence:
MKNQSRVLNSELGDFDLSVLWDQILNFEGYGSYCFRPMDMDGYHKRSAGLNPCKHSGFSHSSRPMAPGIYRYPEVKSSLRRQVHAPVRILNSGRDRSTRQGSGNVLGTFLTRNNDMWKRNALDSSLRYRTDREVIDVDDELGDVEMISDDTSREGVENVAMEVDEVEEKAEMGNGLFSEVASLKNGSLRVGECSKANSSSLVVNRPVTDVTSFEAYRKVLESAVNRTSKLKDRGFVDFFKERGRALLRSLSSFWRQDEEPVEVVQREAFVPLSREEETAVRRAFSANDSNILVTHKNSNIDITGKILRCLKPGKWLNDEVINLYMVLLKEREAREPKKFLKCHFFNTFFFTKLVNSATGYNYGAVRRWTSMKRLGYHLKDCDKIFIPIHMNIHWTLAVINIKDQKFQYLDSFKGREPKILDALARYFVDEVRDKSEVDLDVSRWRQEFVQDLPMQRNGFDCGMFMVKYIDFYSRGLDLCFTQEQMPYFRARTAKEILQLKAE