wanglab/gogpt-training-data huggingface dataset:
Protein: Laminin beta 1 (Laminin subunit beta-1a precursor) (Q8JHV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
Sequence:
MLLQLAALSILGAWALADVPELGDVCTEGSCYPATGDLLIGRAQQLLATSTCGVHKPEPFCIVSHLQEEKKCFVCDSRQAYNETAHQVTSHSIENVVTTFAPNRLKTWWQSENGLENVTIQLDLEAEFHFTHLIMTFKTFRPAAMVIERSADFGNTWQVYRYFAYDCESSFPSVSHGPMTKVDDVICDTRYSDIEPSTEGEVIFRVLDPAFRIEDPYSPRIQNMLKITNLRVKFTKLHTLGDNLLDSRIEIKEKYYYAIYDMVVRGNCFCYGHASECAPVDGTGEAVEGMVHGHCMCNHNTIGLNCERCQDFYHDLPWRPAEGRNTNACKKCHCNHHSHSCHFDMAVYRASGNVSGGVCDDCQHNTMGHNCEQCKPFFHQHPEKDIRDPNICEPCNCDPVGSLNGGVCDPMTDVSLGLISGQCRCKPNVEGERCDQCKQGHYGLSEDPLGCQPCTCNALGTVPGGSPCDTDSGNCYCKRLVTGRNCDQCLPQHWGLSNDMDGCRPCDCDHGGAINNNCSPVSGQCQCREHMFGRRCDQVESGFYFIALDHYTYEAEEAKFGPGVTVVPRNHPQDRSPTWTGIGFVNVPEGAFLEFSIDNIPYSMEYDLIIRYEPQLPEQWEEVLMTVIRPRVITADSRCANTMPDDDNQMVSLHPGSRYVVLPRPVCFEEGLNYTVRLSLSLYSALSDVQSPYTLIDSIVLMPHCKNLDIFSGSGTEGGNLVTNSAWENFQRYRCLENSQAVVKTPMTDICRNYIFSVSALLHQGVKACQCDPQGSLSTVCDPSGGQCQCRPNVVGRNCDRCAPATFLFXPQGCRPCDCSPEGSVHSYCHEATGQCECIAGAYGRQCDRCLPGYWGFPNCRPCTCNGHAEQCDPQTGQCLSCRDHTTGHNCERCLGGYYGDPVLGSGDHCRPCMCPDGPGSGRQFSGACYKSPDSSQVFCVCNQGYKGARCEECAPGYYGNPHEVGGECRPCQCNSNIDMMDPESCDARTGACVKCLYHTEGESCNRCRLGYYGNALTQSCRKCVCNQMGTVEEMCPSPGNCNCDLTSGQCLCLPNVVGQHCDQCAPDTWNMASGKGCEDCDCDPNHSFGSSCNEIMGQCSCKPGFGGRTCRECRELFWGNPEVKCHACDCDPRGIAEQQCNKVTGHCVCVEGVSGPRCDTCARGYTGEFPQCERCHQCFAEWDIIVGDLTNQTHRLVQKVNTIKATGITGPYQATINNVENSANSIRNILAQNPATQPLTEIQGLLEQATALMAEMNSNLNLTEETLSEISSDNNSTDTKLKSLKEEAQKLEQTVKDLREQVEFVKNSDIRGARASVTRYYEQSQNAEIRANASTTDPYNLVNQSATLRTETEELMNQTKEEFNQRQDEFSKKLDNLAGQLETLDLSELSEKTCGSPAGSENCADSRCGGLSCVDMQGSRKCGGEGCDGLTTLAHNAWQKAKDFDLEIISAMEEVDKLSKMVSEAKVKADEAKLNAQEVLAKTNETKKRVDSSNEELRQLIKQIRDFLTQDGADLESIEAVANEVLQMQMPTTPAQLQNLTEEIRERVGSLTDVEDILNQSAADILRAESLLEQARKARKEASDVKSTAEMVKEALQHAERAQNSVAEALKQAAVDIKGTQDLLVSVESETSDSELKLSNATRRLLKLESDVALLKEKALNTSISANSTEKEAESINALAEQLKKDLDSELKDKYSTVEELITQKAEGVAEAKKRAEKLQEEARNLLLQASEKLQLLKNLEKNYDQNQKLLEDKANELVDLEKAVKELLQEISHKVTVYSTCLF
Protein: Beta-mammal/insect toxin To1 (NaTx12.1) (Toxin Tc49b) (P60214)
Organism: Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Function: Beta toxin that show multiple effects. It enhances the open probability at more negative potentials of human Nav1.3/SCN3A and Nav1.6/SCN8A, of the insect channel BgNaV1 and of arachnid VdNaV1 channel. It promotes an important shift in slow inactivation processes as a function of the prepulse voltage in human Nav1.3/SCN3A and Nav1.6/SCN8A and a small shift in Nav1.1/SCN1A, Nav1.2/SCN2A and Nav1.4/SCN4A. Finally, it reduces the peak of sodium currents in Nav1.3/SCN3A (80% inhibition at 70 nM of toxin), Nav1.6/SCN8A (55.3%), Nav1.1/SCN1A (53.3%), Nav1.5/SCN5A (46.7%), Nav1.2/SCN2A (42.7%) and Nav1.4/SCN4A (20%) voltage-gated sodium channels. It has also been shown to affect the sodium current permeability of rat cerebellum granular cells in a partially reversible manner. In vivo, an intraperitoneal injection (20 ug) into mice produces excitability, respiratory problems, convulsions and death, within the first 30 minutes after injection.
Subcellular location: Secreted {ECO:0000269|PubMed:11821128, ECO:0000269|PubMed:15025998}.
Interaction partners:
Sequence:
MTRFVLFISCFFLIDMIVECKKEGYLVGNDGCKYGCITRPHQYCVHECELKKGTDGYCAYWLACYCYNMPDWVKTWSSATNKCKGK
Protein: Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18) (A0JPJ0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Glutamine-dependent NAD
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Nicotinate phosphoribosyltransferase
- Nicotinamide phosphoribosyltransferase
- Nicotinamide riboside kinase 1
- NAD kinase
- NAD-dependent protein deacetylase sirtuin-1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- Nicotinamide riboside kinase 2
- 5'-nucleotidase
Sequence:
MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYLNATGEYKVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRHHQEKLATGSRSHPQSSPVLERPGRKRKWADQKQDSSPQKPQEPKPTGVPRVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICVTRAGSDAQKFIYESDVLWRHQSNIHLVTEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEEHDLYNSESEDRNAGVTLAPLQRNTSEAKHNHSTR
Protein: Reticulon (Q2NKQ5)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}.
Interaction partners:
Sequence:
METASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
Protein: Aspartate aminotransferase (EC 2.6.1.1) (Q964F1)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSRPFKDLAPVPLDPVFGLARAAKAAPEPKADLVIGAYRDQNGLPYPLKVVRKAERRIVDMGLDKEYPPMTGLLNFVEEAVKLAYGNTVPLERIAASQGLSGTGSLSLGATLLRQVVPEDTPVYVSNPTWSNHVSIFGIVGHKNIREYRYYSPSTHELDFVGLIEDLNVAPQGSIIVLHACAHNPTGVDPSKDQWATIADVFVERKLIPFFDSAYQGFASGSLDEDAYAIRHFAKRGMEMLLAQSFSKNMGLYAERVGVISAVVSDASRKEAVRSRLEVIARSYYSTPPVHGARIAHLVMSDKELRAEWEQELKEMVNRVRSMRQGVYEGLMKLGTPGTWEHIINQKGMFSYMGLSRPQCERLCEKRVFVLPVGRANLAALTPSTMDFLVKSIDDVVRHVRNK
Protein: Uncharacterized protein YGL138C (P53122)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Regulator of rDNA transcription protein 5
- Chitin deacetylase 2
- Outer spore wall protein 4
Sequence:
MYNFLEFFFFFITYTLFKSTFVQGKSSFPGHDVCKFEDQNFQTEFFLNVLKGDKLQNLKQEYEQYKKQSTLYTGFVIEKQYEYQVAPLQINNFLQVTFCKGGKPIWNHILPFQKDLDWAEPLCIPAQEDDTISQNSSVCFKFARVQKYTQRNVTLYFPNKFVGFVFVCNSSKTHPPTQNNFETIPLTPIISDDIRDYKISWSIKGRITKVVPYLHSLSIPMSKYEMLIHSDKNISNELEYKSLTSEFWKSYKNLRKFKNKEMSWINEINPMEQYDSSGNENVPNFHEKLDRTINRIAQNIERPHDALIRAIAAHNRNSNSGNITRRKYLRRKISKMLKNKIPLKN
Protein: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein (Q8BHI6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAEMESAVEGRTASVLFAGFRALGLFSNEVPHVVRYSALKRRFYVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHLLQPFGDHVISVDTDSVLIIWHIYSEEEYLQLTFDKSVFKISTILHPSTYLNKVLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHPIMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGPAGEGRLLRFRMGHSASLTKIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLVNKKIVKRKGLQNTMSVRLPPITQFAAEEARQSDWDGIIACHQGKRSCSTWNYQRSTIGAYFLKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDDKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSLGLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMVKQTAFQISSLISCLGERCLNN
Protein: UPF0756 membrane protein YeaL (P0ACY6)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01874}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01874}.
Interaction partners:
Sequence:
MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLNWKSLVAIAVGVIVSWLGGRGVTLMGSQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ
Protein: Flap endonuclease Xni (FEN) (EC 3.1.-.-) (Exonuclease IX) (ExoIX) (P38506)
Organism: Escherichia coli (strain K12)
Function: Has flap endonuclease activity, but does not seem to have exonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
Interaction partners:
- Beta sliding clamp
- Protein RecA
- DNA polymerase II
- DNA mismatch repair protein MutL
- Exodeoxyribonuclease III
- Nuclease SbcCD subunit D
- ATP-dependent DNA helicase RecQ
- DNA mismatch repair protein MutS
- Exodeoxyribonuclease 10
- Ribonuclease HI
Sequence:
MAVHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIMHSQPTHAVAVFDDENRSSGWRHQRLPDYKAGRPPMPEELHDEMPALRAAFEQRGVPCWSTSGNEADDLAATLAVKVTQAGHQATIVSTDKGYCQLLSPTLRIRDYFQKRWLDAPFIDKEFGVQPQQLPDYWGLAGISSSKVPGVAGIGPKSATQLLVEFQSLEGIYENLDAVAEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLVR
Protein: FACT complex subunit (G0SDN1)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367052}. Chromosome {ECO:0000256|RuleBase:RU367052}.
Interaction partners:
- FACT complex subunit POB3
- Cell division control protein 73 C-terminal domain-containing protein
- Transcription elongation factor SPT5
- Histone H2A
- Tetratricopeptide repeat protein 1
- RNA polymerase II-associated protein
- RNA polymerase II-like protein
- DNA-directed RNA polymerase subunit
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MADIKIDSKLFQERISHFISAWKADKRSGDALFGGVSSIVILMGKVDEEPEFYKNNAMHFWLLGYEFPTTLMLFTLDTLYIITTQKKAKYLDQIKGGRFPVEVLVRGKDNAENEKTFIKIADMIKAAGNKVGVLTKDTSKGPFIDEWKKIFAERCKGVEEVDIALALSAGAFSIKDETELRAMRTSSKACVALLTPYFLDEMSSILDQDKKISHASLADKVMNKLEDEKFWKTVELPNRGKLPSDFDPEQLDWILGPIVQSGGKFDLKWQTDSDDEPLHPGIIIAAMGLRYKSYCSQIARTFMVDPNKSQESNYRVLLAVHNLILKEIRDGVVVKDVYNKAYNLIKTKKPELEKHFLKNVGYGIGLESKDSTLILSAKNTRTLKDGMTLCIVTGFSDIPNPDPQGKKDKVYSLVLTDTIRVTTGEPVVFTGEAPSDMDATSFFFKDEEEAQPTPKKEKKDPRVGAVATRNITSTRLRSERNTAPDEDAEKRRREHQKELAAKKQKEGLLKYADATAGQNGVEVKKFKRFESYKRDNQLPPKVRDMGIVIDQKNNTIVLPIMGRPVPFHINTIKNASKSDEGEWSFLRINFLSPGQGVGRKDDQPFEDASAHFVRSLTFRSTDGDRYAEIANQISNLKREAVKREQEKKDLEDVVEQDKLIEIRNRRPAVLDNVYIRPALEGKRVPGKVEIHQNGIRYQSPLSTTQRVDVLFSNIRHLFFQPCQNEMIVIIHLHLKDPILFGKKKTKDVQFYREAIDIQFDETGNRKRKYRYGDEDEFEAEQEERRRKAELDRLFKSFAEKIAEAGRNEGIEVDMPIRDLGFNGVPNRSNVVIYPTTECLIQITEPPFLVITLEDVEWAHLERVQFGLKNFDLVFVFKDFTRPVVHINTIPVESLEDVKEFLDSSDIPFSEGPLNLNWSVIMKTVTANPHQFFLDGGWGFLQNDSDASDASEEEEDEDSAFEISESELEAASESSEEDSDYEDASEEESDAPPSEDDEGESWDELERKARKRDRESGLDDDDRGGKKRRR
Protein: Tyrosine phosphatase, putative (Q382T8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine/threonine-protein kinase, putative
- separase
- Cell division control protein 2 homolog 1
- Uncharacterized protein
- Cell division cycle protein, putative
- Uncharacterized protein
- Serine/threonine-protein kinase PLK
- Serine/threonine-protein kinase, putative
- Serine/threonine-protein kinase PLK
- non-specific serine/threonine protein kinase
Sequence:
MPRPLRELLERKQAIEVIPGVLYFTSVSERLHDIEAELNNSPTPQEDTCNVNSAMKAPNFGDFAFAAPPSLHSESVPSAAIQGANVIGEDLQVKIPHGFRGSVANNAAFQRRLRERLGEGGGCYGVLEDDAFYFTLGNGPRFQYQPFFADFGPLGLDCVTALSRYLKSLLELCASFRSDDSDSNQEMKASQNNVFDFVHFNTNESLSGGLLWGGISEHVIPVVFCSGLGNHERANAACLLACFCVAGLRWSAAETWRIFQEAFPPIISFRDASYGVSTFPLSLSDILGGLQRAVELGWYDPNTFDLQEYDRLRIYDCCWIIPKALLTFSSPVSGDPNRDPVMYAKLFQELRVAGVVRLNEPLYDRHAFLSRGIQHEDLEFPDGTAPNDAIINRFMEVVDPILSVQPPATHSDARKRATKERETSDSVDLHPKGREDVRFRGRLKSDSRGGAVAVHCHAGLGRTGTIACTYIIRRYGFTARGAVGWTRLCRPGSVMGAQHMFLEKFERRLLRPVKSLDFLHAQRHLRVVGSGVVSHLSAYSYQTHKLRHTSSMNESVTSLSLSLSGLSGHSTRSPSGQCEPLSLATPAPSANMNRVKRPSRVVIRGRSSQCSTSQGSHVNNNRRSPVAEALRANPIAALRTLVTNSGRSHNSTDLDREEVRRLPDGGCGDSLGTTTVSGVPLHSSLQSRRPRGRTSCVTPPRVQALVNESRRHLNARLSVLSVGNEGKGTSPDERYDLAPEVKCCLPTAVGPKGENLLAVNATALGFFAATGCTNGGANPFTPRVCHTSPREARALPSAQFQKGAADPGWGGRVVFLQP
Protein: Growth factor receptor-bound protein 7 (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) (Q9QZC5)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14451}. Cell projection {ECO:0000250|UniProtKB:Q14451}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14451}. Cell membrane {ECO:0000250|UniProtKB:Q14451}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14451}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14451}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q03160}. Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions. {ECO:0000250|UniProtKB:Q03160}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-2
- Receptor tyrosine-protein kinase erbB-3
- Receptor protein-tyrosine kinase
- Mast/stem cell growth factor receptor
- Receptor tyrosine-protein kinase erbB-4
- Platelet-derived growth factor receptor beta
- SHC-transforming protein 1
- GTP-binding protein
Sequence:
MELDLSPSHLSSSPEDVCPTPGTPPETPPPPDNPPPGDVKRSQPLPIPSSRKLREEEFQATSLPSIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDENWGLVECHPYLALERGLEDHESVVEVQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCLDTPTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADINESNVYVVTQGRKLYGIPTDFGFCVKPNKLRNGHKGLHIFCSEDEQSRTCWLSAFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIENPQEALSAATEEAQAWRKKTNHRLSLPTPCSGLSLSAAIHRTQPWFHGRISREESQRLIGQQGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCARVAL
Protein: 3-dehydrosphinganine reductase (EC 1.1.1.102) (F1QWW8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum {ECO:0000305}.
Interaction partners:
- Serine palmitoyltransferase, long chain base subunit 1.
- Serine palmitoyltransferase, long chain base subunit 3.
- Serine palmitoyltransferase, long chain base subunit 2b.
- Serine palmitoyltransferase, long chain base subunit 2a.
- N-acylsphingosine amidohydrolase
- Ceramide synthase 3b.
- Sphingosine kinase 2.
- Ceramide synthase 5.
- Ceramide synthase 2
- Acid ceramidase
Sequence:
MLLVVAAFIVAFVLLLYMISPLISPKPLKLNGAHVVVTGGSSGIGKCIAMECYKHGAFITLVARDEHKLVQAKKEVEKFAINDKQVVLCISVDVAKDYSQVESVIKQAQEKLGPVDMLVNCAGTSLSGKFEEVEVDHFKKMMEVNYLGSVYPTRAVITTMKERRMGRIMFVSSQAGQIGLFGYTAYSPSKFALRGLAEALQMEMKPYNIYVTVAYPPDTDTPGFAEENKTKPLETKLISETSGVSQPEQVAKIVVKDAVQGNFTSSFGPDGYMLSALTCGMSPVTSITEGLQQIVTMGLFRTIALFYLGSFDSIVRRCMIQREQCKAADKRE
Protein: Small ribosomal subunit protein uS9B (40S ribosomal protein S16-B) (RP61R) (P0CX52)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR
Protein: HD domain-containing protein (Q583P4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MEGELAFVKSEHVLDNITGKELDAFKLQEHSGDKVYVPPNSNGNFDLKVGQQYTNIGRDTSESQKTEGGKTVLLHSPTSLTPTKKLSSVGDIAVSAASVLDVDGKDLFLSPKEAKNVIDDAEGSVIFSQKGRDTPSICGAAEGVRLQDGARDMLFFSPLLQPLEAGGKNFQDPVHEYVHLPNVAIRIIDTVEFQRLRTVKQLGTVCFLYPAATHTRFEHSIGVAHLASEMLKHIASCQPELGITRADVLSVIIAGLCHDLGHGPFSHSFEVAVNRIRSKTGARKLWRHEHMSVLLLRRILKKIEIRKYGLNEDDVRFIELCITGLHPSKRWPENIGRPEKKRFLLEIVSNKRNGMDVDKLDYFHRDSIACYGRAAVDVQIRRLLKSCKVLCCEEQHQICFEEKMALSLGDIFSVRAKLHKHAYQHRVTLAIEQMMIDALYEAEPFFLVPGKNGRKLRLSECVDDEEAFCKLGDWILEGITASDDPRLAKSQSLIRRIMERDLYSVVGIKTFISYNVELGEDDIRSYMIQHCKMLGRYSEKLDSNLLVNFINITYDKTDKSGIPNDPIAHMAFYSPKNVGAGAFRLPKERKSHIFSPISYGEKSVIVFVKEKVFVDVIRDAFGVWVSAHANLLVVAVPAHNGRTEESPTGSAQSSRSQCLSGRADNQDSSSNNNDTVTILTAPRAYVEGFTGFSSSQTNGIPSYCQSESESTQASQCSASGLKLSEGNLAGNKRSR
Protein: Protein unc-119 homolog A (Retinal protein 4) (hRG4) (Q13432)
Organism: Homo sapiens (Human)
Function: Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}.
Interaction partners:
- ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 2
- Nephrocystin-3
- Macrophage immunometabolism regulator
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Peptidyl-prolyl cis-trans isomerase E
- Membrane-associated phosphatidylinositol transfer protein 3
- Interleukin-5 receptor subunit alpha
- Protein unc-119 homolog B
- Tyrosine-protein kinase Lck
Sequence:
MKVKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPDAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP
Protein: Unpaired protein (O96525)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MARPLLLLLPILLVLLLAAQLPHLAEGRSTTSSGGLTVIDSERLPIRTTSSTASAQHPNQGTIPASAASPRKRHRKRNSNWIDYRNFDENTTALEWANPCGGNYHPSAGDRFNRQRPRQSFNQLKRHAFREYRSLNSSQDSAIDIRNMTMWSLHTHNYKFLPKLKPNSTIALKRWYRNMQTYVASFAYLRRQQIRWDQRSITRESSTARELRELLLSSRRILCELETAVNQTQSPRQKQRRSGAAVTAVGGTTMLGQQLPQISRLEMNKRLKLRSKTSGPGMGGAASSASMAAGEADSIDMRFVKHHYYDFLRTMYQLLRRDGKRVRSRPRKHHKKQQRSQKKLLQQQQQLADQLEQRWRSSTLNGKEFNEVSKPVAGGAAGVADVAGVSGGGSNQFARGRRGKRQSKRVQRT
Protein: Nervy, isoform B (Nervy, isoform C) (A0A0B4KFZ8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALDGKAIIKEEITDKDAYDAAAAAAAAVAAGAALAVASAAAVQVPPASSSSAGSASSAAAAATNNTTSAAATAAAISRRLKASSSGGDKSSTSSSSSKDSSHTSSSRSERDRERERERERERDRLCRTPPDSPPDSSRSLAPRSPHSPLQLHQHPQRNASVSPVVNGSSSGGGGVGSSGTSPTPTPGSQHAASLAAAAAAAAAAHVEQARLVSKMRKFLGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALARATNQSALQYVTNNEQAVMEFAPHGVASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSMMEHGGHNGLQEWNEYMASGGAGYPPPPSKRLTLHPAHSVVAYGEYGVSSAEGLPSAAAFMQRDERDLRMSEAQARHAAPPQRAGNPQPNPNAAAPGAPGAGGEEEWKNIHTMLNCISAMVDKTKRAITILQQRGIEPQHPNSGQEVTPAAMAELRRQTEEKVAEFKRNAEDAVTQVKRQAVIEIQRAVVAAETRAAEIMTQERLRMEKFFMEMSRHSSGERDLDNKSPSMASAQNGSNLQQQCWNCGRKATETCSGCNMARYCSASCQYRDWDSHHQVCGNTRASELSAKHLHSASNLSLRNAMATRSPPTPNSAAHLQAAAAAAAAAAGAREAVSAPVGGPGAGIAVGTGAGSGGQSGGGGGGGGGGGGGAAAAAVAAATPGALVANGLGSK
Protein: Tonoplast monosaccharide transporter3 (F4J4E8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVSGELALLVEGLGVGKDTSIEEYVIGPDNEENEGGNELPRKDQIKLYGPEDGQSWMAKPVKGQSSLALASRQGSMLPRGGSLMDPLVTLFGSIHENLPSENMNASSRSMLFPNMGSILGMMGRQESQWDPERNNEDSSDQDENLNSPLLSPQTTEPDDYHQRTVGTMHRRQSSLFMANVGETATATSIGGGWQLAWKYNDKVGADGKRVNGGLQRMYIHEETANNNTNNIPFSRRGSLLSFHPEGDGHDQVNGYVQAAALVSQASMMPGGKGETAMLPKEVKDGPGWRELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSLLTNLGISAESASLLISALTTLLMLPCILVSMRLMDVTGRRSLMLSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVISEFFSVGAKQQDAAASFLSDG
Protein: Dysferlin (Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)) (E7F4H1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004483}.
Interaction partners:
- Caveolin
- Dystrophin
- EH domain-containing protein 2b
- Annexin
- Annexin.
- Annexin.
- Annexin
- AHNAK nucleoprotein
- Annexin.
- Calpain-3
Sequence:
MLRVFILCAQNVLTHDEDISDAYCTVTYEGTKKKTKVIKNNVNPVWNEGFEWDLKGVPLDSGAELHVVVKDHEKMGRNRFLGECRVALRDVLNSPNLAATFTVSLVDTKRNSTGATITLQVSYIPPPGMTPIFQPPPQPEAQHTPVELDTVTVFSLDTMGEDDTESMLMMEVAEEPEPVPGPQGQDIGAPTAPPKKAPPNFNQGLKKKKRQSNKSPLSDKAQDLQVRLRIIEGRQLPGVNIKPVVKVTVGGQTKRTRIKKGNNPFFDETFFLNFFEKPSDLFDEPIFITVFDSKSLRKDSVIGEFKLDVGMVYNEHRHAILRKWLLLADPDDLSAGARGYLKVSMFVLAAGDEPPMDKKEGVEEKEDIEANLLRPAGLTLRGATFTLRVYRAEDLPQMDDALIDDVKHFLGFDTNRKNLVDPLVEVNFAGKTISSKILEKCANPQWNQCLTLPIRFPSMCEKMRIRILDWDRASHNDVIGTAHLCMSKISAPGGDIEDEFPARTLHDTMDDSIGFLPTFGPCFVNMYGSPREFTAFSDPHEALNLGKGEGVAYRGRVLLELITKLSDQVDQRSEDINSDDLLVVEKFMRKRKFSLFAAFYSATLLQDVDDAVQFEVSIGNYGNKFDNTCLPLASTTQFSRAVFDGCHYYYLPWGNVKPVVVVSSEWEDIGPRIEALNMLLSIVDRLESNLEQVQLELKARSDDQEVEQRVVQLLDDVIADCSEELPELDKWPCVTPLDKALRNLRKINMQQIVQAALALKHGPETELSAVLEQAEDWTMRLRYLSEEPQNSLPDIIIWMLQGDRRVAYHRIPAHQVLFSYGYCGKHCGQLQTVFMKCPQEDGGCSKIPAQLRIKVWFGLTADVKSFNQFAEGKLSVFAETYENQTKLALVGNWGTTGLTYPKFSDVTGRVKLPKESFKPSSGWSWAGEWFISPEKTMLYDADAGHISFLEEVFENQLRLPGGQWIGMPEGYTDVNGEKAVPKDEIECPPGWVWEDIEWSEDLKRAVDDQGWEYGITLPPDRRPKSWVPSEKMYHTNRRRRWIRLRRRDMQKMEALRKQRPDESEREGWEYASLFGWKFHLKQKKTDLFRRRRWRRRMEPLEKTGPAAIFALECSLSSFTDEKNDDKSVTTTFGVSRPTISCFFDSGTLYHLRCYLYQARDLLAMDKDSFSDAYAVVSFLHQSQKTVTVRNTLNPTWDQTLIFYEVEIFGDHLVTERSPPNIVVELYDQDTYGADEFMGRCVCQPSMASSPRLAWYPIQKAGNSAGDLLAAFELIRRDKPAVHHIPGQEGDIIPPSHIMDELVLPGFLSENQQQWPEDSDLPYPPPQREPNVYMVPQGIKPVLQRTAIEILAWGLRNLKSFQLASVTSPSLQVECGGSVVQSCVIRNIKKNPNFDVNILFIDVRLPKEELYMPPLVIKVIDNRQFGRKPVVGQCSVHSLNEFYFQPESLERDSTEEEFEVIAHTPRDDVLVDIDDKEPLIPGQQDEFMDWWSKFYASMGERTKCGSYLEKGFDMLQVYDRELEKTEGFEQFADFCQTFKLYRGRTQNDSEDPSVVGEFKGSFKIYPLPDDPSMPVPTRQFRKLPPNGIEECLVRIYIIQAFGLQPKDANGKCDPYVKITLGKKSVDDHDNYIPCTLEPVFGKMFELTCCLPLEKDLKITLYDYDMVTKDEKIGETIIDLENRFLSRHGARCGLPQSYCLSGINQWRDQLKPSQLLHRLCERRNYKLPVYKQDRIYFRGHEYTVADLDEGKPLNPHLGPVMERLALLVLRRHGLVPEHVETRPLYSPLQPDIEQGRLQMWVDLFPKSLGPPGPPFNITPRKAKKFFLRCIIWNTRDVILDDVSVTGEKMSDIYVKGWMHGHEENKQKTDVHYRSLGGEGNFNWRFLFPFHYLPAEQLCTIDKKEHFWSLDKVETKLPPKLTIQIWDNDKFSFDDFLGSLEMDLNHMLSPAKSPEKCGLEMLTQSQDKLVSLFEQKTVKGWWPCVCDKEDKKILAGKVEMSLEIVCEQEQDERPAGLGRDEPNMNPHLEEPQRPETSFLWFSSPYKTFRFIVWRRFKWLILGLFILFFIILFLGVFLYAFPNYAAMKMVGPFSGLGKGTQ