wanglab/gogpt-training-data huggingface dataset:
Protein: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) (A4VAR9)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}. Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
Sequence:
MTVGCVPQPPFLGRTLLPVLLLAASARCHWPSEPAEVVRDWENQLEASMHSVLSDLRETVPAVVGIPDSSAVVGRFFRVSIPTDLIASNGEAVQVSEAGKESLPSWLHWNAESSSLEGLPLDTDKGVHYISVTTLQPFPNGSYVPQAANVFSVEVHQEDHSEPQSLRAAAQEAGDAAPFVCGAEEPVTILTVILDADLTKMTPKQRIELLNRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLSQNSVPNISKVEAPAKEGTMSARLGYPVVGWHIANKKPHLPKRMRRQINATPTPLTAIGPPTTAAQEPPTRIVPTPTSPAIAPPTETTAPPVREPIPLPRKPTVTIRTRGPIVQTPTLGPIQPTRLVEGTGTVSVPIRPTVPGYVEPTAVITPPTTTTKKPRVSTLKPATPSTTDSSTATTRRPTRRPKTPRPTKPPSTTRSTISKLTTASPPTRVRTTASGVPRPWEPNEPPKLTNHIDRVDAWEGTYFEVKIPSDTFYDKEDTTTDKLQLTLKLKEQQMIEENSWVQFNSTSQLMYGMPDRSHVGKHEYFMYATDKGGLFAVDAFEIHVHKRPHGDKSPVKFKARLEGDHSAVANDIHKKIMLVKKLALAFGDRNSSTITVQDIAKGSIVVEWTNNTLPLEPCPREQIRTLSKKIAEDSGGASPAFSNILQPEFKPLNVSVVGSGSCGHIQFVPVTKDGRVISEATPTLAAGKDPEKSSEDDVYLHTVIPAVVVAAILLVAGIIAMICYRKKRKGKLTIEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSMPETTPLNQDTIGEYTPLRDEDPIAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP
Protein: Cysteine-rich receptor-like protein kinase 10 (Cysteine-rich RLK10) (EC 2.7.11.-) (Q0D5R2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in disease resistance. Required for NPR1/NH1-mediated immunity to the bacterial blight pathogen Xanthomomas oryzae pv. oryzae (Xoo). Required for the benzothiadiazole (BTH)-induced immune response. Probably regulated by the transcription factor TGA2.1.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSMACYYLAAAAAGLALLLLHAPLTDAQTLVPLCGDSGNYTEHGTYHANIQYLATSLPSYASSSPSLFASGSSGTVPDAIYALALCRGDTNSSSCATCVAAAIQSAQELCPLVKTVIVYDDTCILRFANDAFPISPTSNSQGMVVAWKAQNVSAAVAPAFEAAVVRLINTTADYAATDSVRRFGTGEEAFDETTFPKIYSLAQCTPDMAATACRSCLEDIVGRMVSGNLIGRMGGRVLGVRCNLWFEVYPFFSGRSLLQLPGPSPSPAPPVTAAGERSKNKRSAILAISMPTIALVLATIAAWFCSTSWRRRRLARKTLRPKSSEDEMQSFASLVLDLQTLRTATDNFSEHKRLGEGGFGVVYKGDLPEGQEIAVKRLAQTSRQGIEELKTELLLVAKLNHNNLVRLIGVCLEENEKILAYEYMPNRSLDTILFDAERIKELDWGQRFKIINGIARGLQYLHEDSQLKIVHRDLKASNVLLDSAYNPKISDFGLAKIFERDQSQVITHRIAGTYGYMSPEYAMRGQYSMKLDVYSFGVLVLEIITGRRNFGSYGSDHVVDLIYVTWEHWTSDKAIELIDPSLGNHYPVDKVLKCIHIGLLCVQPKPADRPLMSAVNAMLSSTGTVRLPCLSRPSFWVQEIGATAS
Protein: Cyclin-dependent kinase G1 (EC 2.7.11.22) (Q9FGW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cyclin-dependent kinase involved in pre-mRNA splicing. Required for the correct splicing of the sixth intron of CALS5 pre-mRNA. May stabilize the binding of U1 snRNP to this rare type of intron with a GC 5'SS. Involved in chromosome pairing and is required for the completion of synapsis in male meiocytes at high ambient temperatures.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:23404887}.
Interaction partners:
- Cyclin-L1-1
- Splicing factor U2af large subunit A
- Probable inactive E3 ubiquitin-protein ligase SINAT6
- ATP-dependent helicase/deoxyribonuclease subunit B
- Callose synthase 5
- Nuclear protein-like
Sequence:
MAAGGVDVSRSSVAVKKDYDFYRNGSRDVYVRQSGRDDERRQIKRPSDHDLRRNDGRHRSRLAYEKGELREEAEVQRPSEKRRKFSPIVWNAEKVGRAPSREKTKSPFPVPTTTVISNQAVAGKTTSNDQVNALMSPEPSYLAPVQPSEALLAVKHPVDDLEEGQLEEEQVMQEDVKEGLLEEEQVMQEPNIKTSRWGTGLTSPKEELISVNVSKTNRWNRSSLTPECEEVMVSEEQQCYSSGSGSGHLSVEKLSADGNSGREYYSSDHDELEHEDQDSLTPGEMNMMFGSRSVNEFQKLNKINEGTYGIVYKARDEKTKEIVALKKIKMKEDRFEEEYGFPLTSLREINILLSCNHPAIVNVKEVVVGGKNDNDVYMVMEHLEHDLRGVMDRRKEPFSTSEVKCLMMQLLDGLKYLHTNWIIHRDLKPSNLLMNNCGELKICDFGMARQYGSPIKPYTQMVITQWYRPPELLLGAKEYSTAVDMWSVGCIMAELLSQKPLFPGKSELDQLQKIFAVLGTPNEAIWPGFSSFPNAKAKFPTQPYNMLRKKFPAISFVGGQILSERGFDLLNSLLTLDPEKRLTVEDALNHGWFHEVPLPKSKDFMPTYPPKR
Protein: Actin-related protein 2 (Actin-like protein 2) (P61161)
Organism: Mus musculus (Mouse)
Function: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61160}. Cell projection {ECO:0000250|UniProtKB:P61160}. Nucleus {ECO:0000250|UniProtKB:P61160}.
Interaction partners:
- Actin nucleation-promoting factor WASL
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 3B
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 3
- Actin nucleation-promoting factor WAS
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 1A
Sequence:
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
Protein: Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) (P55055)
Organism: Homo sapiens (Human)
Function: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Retinoic acid receptor RXR-alpha
- Retinoic acid receptor RXR-beta
- Phospholipid-transporting ATPase ABCA1
- Nuclear receptor coactivator 2
- Retinoic acid receptor RXR-gamma
- Solute carrier family 53 member 1
- Nuclear receptor coactivator 1
- Oxysterols receptor LXR-alpha
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- ATP-binding cassette sub-family G member 5
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Protein: Lactose operon repressor (P03023)
Organism: Escherichia coli (strain K12)
Function: Repressor of the lactose operon. Binds allolactose as an inducer.
Interaction partners:
- Beta-galactosidase
- Lactose permease
- Arabinose operon regulatory protein
- Galactoside O-acetyltransferase
- DNA-binding transcriptional dual regulator CRP
- Protease 7
- Deoxyribose operon repressor
- Xylose operon regulatory protein
- Trp operon repressor
Sequence:
MKPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLAPNTQTASPRALADSLMQLARQVSRLESGQ
Protein: glutamine--fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) (Q582H1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- glutamine synthetase
- Glucosamine-6-phosphate isomerase
- Glucosamine 6-phosphate N-acetyltransferase
- Glucose-6-phosphate isomerase
- mannose-6-phosphate isomerase
- Carbamoyl phosphate synthase arginine-specific large chain
- Phosphotransferase
- Phosphotransferase
Sequence:
MCGIFGYILHRIPCTTRDVLNVLLDSLQRMEYRGYDSAGLCVDDVKSKKHIVVRSVGNISKLRERVFSGCADLDFNAQLENHEGIAHTRWATHGPPSEANCHPQASNNMEFVVVHNGIITNFMTIKQMLLEEGYHFSSDTDTEVIVVLAEHIFSMDHSISFADLAGKVMAELDGAYALLIKSVHFPGELIACKEASPLVIGLQNGKSNGTASGIANGSVMNKLFFSSDVASFLPYTQEVIFLEDGDVAHYSKGALTLYNDATPVSRTSQTVDVSPEGLCKGAYPSFMLKEIYEQPESVSRSMRDRIDFNTREVTIKEMSDGVRTTLLSARRLMLVACGTSFHSCVAARPIFEELLPNISITLENAPDLLDREPRIGSDDVCIFVSQSGETADTLMALQYCKKYEAMIVGLTNVPGSSVLRLSDFALLLNAGVEVGVASTKAYTSQVVVLTLLALFLSKENCSGNSSHSHGGSQSPIQKRRLEIIDGLAALPGALSHCLKCTNDVATKLAEELCDAKAILILGRGYDYATALEAALKVKELTYIHTEGIHCGELKHGPLALVDEHSTIVAFCPHDKFLGRSKSAIQQVKARGGRVVAITTEPDAELVSATSRCVEVPAIVDCLQGIVNVVPLQLLAHHLAVRRGLNVDCPRNLAKSVTVQ
Protein: At2g23110 (Late embryogenesis abundant protein, group 6) (Similar to late embryogenesis abundant proteins) (O64820)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Late embryogenesis abundant protein At3g53040
- Late embryogenesis abundant protein ECP63
- Late embryogenesis abundant protein 32
- Late embryogenesis abundant protein
- Desiccation-related protein At2g46140
- Late embryogenesis abundant protein 3
- Late embryogenesis abundant protein 31
- Late embryogenesis abundant protein 18
- Probable dehydrin LEA
- Late embryogenis abundant protein 41
Sequence:
MEDQKKPPTTEQEVKEVKNDDLESIKTPYLDYDNLEDYKMKGYGAQGHQEPKLGMGGGATDAPTPSGGLGRGGGAASTDLSSTDAINRQGVP
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FM13)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MPKVAIIIYTLYGHTATIAEAEKKGVEAAGGQADIFQVQETLSPEVVKALGGAPKPDYPIATQDTLTEYDAFLFGIPTRFGNFPAQWKAFWDRTGGLWAKGALHGKVAGAFVSTGTGGGNEATIINSLSTLAHHGIIFVPLGYKNAFPELTNLEEVHGGSPWGAGTIAGADGSRSPSALELKIHEIQGKTFFETVKKF
Protein: Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1) (Q9QX66)
Organism: Mus musculus (Mouse)
Function: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Actin-like protein 6B
- AT-rich interactive domain-containing protein 1A
- Zinc finger protein DPF3
- AT-rich interactive domain-containing protein 1B
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Calcium-responsive transactivator
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- SWI/SNF complex subunit SMARCC1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
Sequence:
MATVIPSPLSLGEDFYREAIEHCRSYNARLCAERSLRLPFLDSQTGVAQNNCYIWMEKTHRGPGLAPGQIYTYPARCWRKKRRLNILEDPRLRPCEYKIDCEAPLKKEGGLPEGPVLEALLCAETGEKKVELKEEETIMDCQKQQLLEFPHDLEVEDLEEDIPRRKNRARGKAYGIGGLRKRQDTASLEDRDKPYVCDICGKRYKNRPGLSYHYTHTHLAEEEGEEHTERHALPFHRKNNHKQFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDDQLLFCDDCDRGYHMYCLSPPMAEPPEGSWSCHLCLRHLKEKASAYITLT
Protein: Putative membrane protein (Q2GIF3)
Organism: Anaplasma phagocytophilum (strain HZ)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Sequence:
MDSYNVRYESAYYCAGLRSYLVRVYNYMALALGITGAVAFIASLSGGLMAAIYGTPLHWVVSLAPVITVFVMSARVHQMSYQTMMMVFLGFSAMMGLSLSYVFMVYTSHSIARVFFISSAMFGTMAWYGNTTKRDLSKFSTFLTMGVVGLIIASVVNLFMRSGPLYFAISVVAVLVFTALTAVNAQEIKDMYYRFNDGDSNTVGKMSILGATSLYFSYINIFVHMLHLMGDRR
Protein: Probable serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) (Q18678)
Organism: Caenorhabditis elegans
Function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Glycine--tRNA ligase
- Phosphoryl Seryl-TRNA
- Lysine--tRNA ligase
- Leucine--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- Tryptophan--tRNA ligase, mitochondrial
- Isoleucine--tRNA ligase, cytoplasmic
- Cysteine--tRNA ligase, cytoplasmic
- isoleucine--tRNA ligase
- leucine--tRNA ligase
Sequence:
MVLDIDMFRTEKGGNPEIIRKSQQDRFKDPKLVDEVIELDEKWRKERFVADQLNRQKNAISKAIGEKMKKKEPQGTDDSVADDIVARLAELKIDELSQLTVVQLKKLRVLVDEKSVQTAAAVIANENARHEKLIQIGNLIHSSVVVSKDEANNKIERTFGDLSTKKKYSHVDLVVMVDGFDGERGTVVAGGRGYFLKGPLVFLEQAIIQLALQRLNVKGYVPLYTPFFMRKEVMQEVAQLSQFDDELYKVSSKGSEIAGDTSVDEKYLIATSEQPIAAYHRNEWIKETELPIKYAGVSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVLCSPNDNESWTLFDEMIGNAESYYQELQIPYQVVNIVSGELNNAAAKKFDLEAWFPGSGAYRELVSCSNCLDYQSRRLKVRYGQTKKLSGEVPFVHMLNATMCATTRVICAILENNQTEEGINVPTAIQQWMPENYRTFIPFVKPAPIDEDAKKATGKK
Protein: Transcription regulator srbA precursor (Sterol regulatory element-binding protein A) [Cleaved into: Cleavage-activated transcription regulator srbA] (Q4WIN1)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23104569}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Cleavage-activated transcription regulator srbA]: Nucleus {ECO:0000269|PubMed:23104569}.
Interaction partners:
- Patched sphingolipid transporter
- Importin-95
Sequence:
MSTPGIGGDFQLFSPLESTRRISQGNSLSVDQSSTDVASQDWTQWMRWDDEQAFPETANASPSSPFDLAFISPSASSGREASDAMHKDFSPDISLDFKSPSLGFFPGGDLNTNVSPQPDHVGAGSLSVHSNSPLSSIGASRKRKTGSDDDGSTMTSMFKAKQAPSKKRAHNVIEKRYRANLNEKIAELRDSVPSLRASYKQANGNSGDDDDDGVTSASKLNKASILSKATEYIRHLEIRNKRLEEENTALKIRLRQLDKAADQIVTSAASVSSPSDCTVSTESGASSSPSVFSHAEDVPSDHSPTSSHPPEGLIKVPDAWKRMRAAGSNESPYSQSYIQYKKTDSHSSQSGGGRMRSHLPNKYMLGALAGLMVLEGLGTEKKTESTAKGLLAVPLNLLNRVQLPSEVYSSAAFQYFWSSWHARAISHFLMLAILVVGSAFIVFVYLFNSDPRRQYSASKVAPDVTLSSCNFRRQAWLTSIQRVGVPRHRFFHEWYVVTSRCFEYVLRCLLGWKLYSLVTGVTEEDEKGRVKTWDIAIDAQLAGGDAEISKSRLVLTIFAAGTLPRSPMRMMLKALHCRILMWRVGEPGSWTFNVSNDVARSLARYQWDLARKMNAALPKDHPDSLPSHLATLLKIDCDDVMIDTIIQRAANLTWNRPTQEGTDDDEALLDVVEEDPAIQSSLDALAAWWSSHLLQGALLRYFEASSGGPDAKKSRNVFKSKIKLALDVAPQPSAAHTRALVMMAVFFERDRVANIGSVLAALPKEKGKNKQNQASNFLDSSLPISVREEISTAVRCAMIAAIFNARATGDTSLPATFTVEKAIHWFNRLPLDPVELTLLEFAAVYHLLHILASDIDYLASSDSSAPPSPMSKASDMLSSSSDDGEDGASQRNNNIIPHPMPNLGRVASELIYWARNAYNPAFYGFTSNLVKVIETECTSLCQTAGVHVADYSCVQEEKSKAKQAIDSKRRFAGGNEEASDNLLLSDES
Protein: Metallothionein-2 (MT-2) (Metallothionein B) (P11956)
Organism: Drosophila melanogaster (Fruit fly)
Function: This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.
Interaction partners:
- GEO10380p1
- Metallothionein-1
- Copper transport protein
- Metal response element-binding transcription Factor-1, isoform C
- RE54080p
- Zinc transporter 63C, isoform F
- Zinc transporter 33D, isoform B
- Zinc/iron regulated transporter-related protein 42C.2
Sequence:
MVCKGCGTNCQCSAQKCGDNCACNKDCQCVCKNGPKDQCCSNK
Protein: Guanine nucleotide-exchange factor SEC12 (Protein transport protein SEC12) (P11655)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Cycling between endoplasmic reticulum and the early Golgi.
Interaction partners:
- Small COPII coat GTPase SAR1
- COPII coat assembly protein SEC16
- Protein transport protein SEC31
- Protein transport protein SEC13
- Protein transport protein SEC23
- Protein transport protein SEC24
- Putative guanine nucleotide-exchange factor SED4
- Protein RER1
- Protein DSS4
- GTP-binding protein YPT1
Sequence:
MKFVTASYNVGYPAYGAKFLNNDTLLVAGGGGEGNNGIPNKLTVLRVDPTKDTEKEQFHILSEFALEDNDDSPTAIDASKGIILVGCNENSTKITQGKGNKHLRKFKYDKVNDQLEFLTSVDFDASTNADDYTKLVYISREGTVAAIASSKVPAIMRIIDPSDLTEKFEIETRGEVKDLHFSTDGKVVAYITGSSLEVISTVTGSCIARKTDFDKNWSLSKINFIADDTVLIAASLKKGKGIVLTKISIKSGNTSVLRSKQVTNRFKGITSMDVDMKGELAVLASNDNSIALVKLKDLSMSKIFKQAHSFAITEVTISPDSTYVASVSAANTIHIIKLPLNYANYTSMKQKISKFFTNFILIVLLSYILQFSYKHNLHSMLFNYAKDNFLTKRDTISSPYVVDEDLHQTTLFGNHGTKTSVPSVDSIKVHGVHETSSVNGTEVLCTESNIINTGGAEFEITNATFREIDDA
Protein: G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) (P48549)
Organism: Homo sapiens (Human)
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G protein-activated inward rectifier potassium channel 2
- G protein-activated inward rectifier potassium channel 4
- G protein-activated inward rectifier potassium channel 3
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid type B receptor subunit 1
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
Protein: Guanylate kinase/L-type calcium channel beta subunit domain-containing protein (O01661)
Organism: Caenorhabditis elegans
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha
- VWFA domain-containing protein
- Voltage-dependent T-type calcium channel subunit alpha
- Voltage-dependent calcium channel unc-36
- Voltage-dependent calcium channel type A subunit alpha-1
- SH3 domain-containing protein
- Four domain-type voltage-gated ion channel alpha-1 subunit
- EGF-like domain-containing protein
Sequence:
MAFRRRGSGDSNFSHHDELELEAGNRETLRRDAERQAALQLERAKYKPVAFAVCTNVEYDGSVDDDSPVHGCAVSFKVKDFLHIKEKYNNDWWIGRLVKEGHDLGFIPSPVKLESLRQQTAKSGKFKQSTSATNLGALDNMMPRSGSRGSTPPTPDDDEYNAKKMTNIVTTPPTKEKKKLIFKKVQQENVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKAVFDYLKHRFEGRIIITRVTADISLAKRSLLNNPNKRAMMERANSRTSNSLAEIQTEIERIFELARSMQLVVLDCDTINHPSQLAKTSLAPIHVYIKISSPKVLQRLIKSRGKSQSRNMNVQMVAAEKLAQCQAELFDVLLDENQLEDACEHLADFMEAYWRATHPPVRSPPRIKRNPMENRGPSTLFTPAQMMQGFQGNAGQLPPQLQPQQSIASMSQMGGPMGSMNPPYLAPPMQSGRPGMPSISVQQATGSYGGMQQQPQQQQPMQSAPPPAPQRQTSYDRHGFDEYDDMDMSHQYERGTYRY
Protein: Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-L-proline dehydratase) (P0DKB4)
Organism: Saccoglossus kowalevskii (Acorn worm)
Function: Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).
Interaction partners:
Sequence:
MHTGGEPLRIVTDGFPKPDGKTILQKRRFVKEKLDNFRKLLMHEPRGHYDMYGALLVEPDIEDADIAVLFMDNRSYSTMCGHAVIALGRYATDYGYVRPTEPETKVNIECPCGLVKALVEYKNGKSGSVRFQSVPAFVFATDVELNVQGHGKVKVDISYGGAFYAFISADKLGLDLWKTPINQIKDAATMVTNAVKNEVQLEHPDDNDLAFIYGTIVTDGKDEYSDEPTANICVFADAQVDRSPTGSGVTARTALQYHKRHISLNKSRVFVNARIGSKFSAKPVRQTKCGSYDAVIIEVSGHAFYTGKSAFTFEEDDPLKGGFLLK
Protein: PHD finger protein 20 (Q5JXL1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQINEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKKDKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAPTAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDTLSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDLDHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVRVKPKKKKKKKK