wanglab/gogpt-training-data huggingface dataset:
Protein: Teashirt homolog 2 isoform X2 (Teashirt zinc finger homeobox 2) (F1QV43)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Meis homeobox 2a
Sequence:
MPRRKQQAPKRAAAYEPDDEVGVQESIEEEEGENAMQTEEENSERPTSKDKDDKDIDNKSSYSFQNSPVSVLSNQEVELESRLSDGSDRLSDFKTSPPGSQKDTETQSSKLKDDMHSSLEKMRAAYANFLSDSYWSKIGLDLKVANTGSKANCDSTNGSTKSEFDWHQDALSKTLQQTLSPKPVSKPNLFSSVHLYRQNSKACGAVFTGASRFRCKDCSAAYDTLVELTVHMNKSGHYQDDNHSRQNIASTSSSKNRKRNLQDMEGKEDAQKVLKCMFCGHSFDSLQDLSVHMIKTKHYQKVPLKEPIPVITPKLIPPAKKRAFEATRPCSPDSTTGVSGYTDAQRSSGLANAPNNRYGYQNGASYTWQFETCKSQILKCMECGSSHDTLQQLTTHMMVTGHFIKVTNSASKKGKQLALDPLAIEKMQTLAEPTVNELEGEKVSPKSTASGDSERATPRDMSPDKAEKNEDKDDKQDEEERKPTDGNFKYPYLREEDLEQQGSSGGGDILKSLANTVASAINKAQTGTPSWSAYPSIHAAYQLSGVIKTASFSPSPPIQLKQNLNHKHRPIAPKGKFYQALRGLESFQGHHNSDIKKERGGASDGKESQSSRFDLVENDDSDCQDDSSSSSKLDADCVSEENDTIKGKLSPAFSDRGNPSPSPPASNGHSTSSELVNDSQEVLSINPLSALQSVLNNHLGKANKPRPESILSHRTQSIFSELSRGLEKPLSASAAIRASNSFMFTNDDQPIDLTKHKHNKPNSSLLLQSSTPMHQKHALSDIADMVKVLPKATTPKPPMPARMPVMKLETDVRRFEDVSSEMYSVHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMHISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDTGHPVFYCNDCASQFRTPSAFISHLENHLGFQIKDMNKLPIEHPTKITEPELSKVLTIRPTDSQITEEESDSKFKCKLCSRTFASNHAVKLHLSKTHSKSPENHSQFVEMDKE
Protein: Protocadherin C5 gamma C-I (Q8K4A2)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MRPMASPQVAGKWQVLCMLSLCCCGWVSGQLRYSVVEESEPGTLVGNVAQDLGLKGTDLLSRRLRLGSEENGRYFSLSLVSGALAVSQKIDRESLCGASTSCLLPVQVVTEHPLELTRVEVEILDLNDNSPSFATPDREMRISESAAPGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLHVKTLKDGKLFPELVLEQQLDRETQARHQLVLTAVDGGTPARSGTSLISVIVLDVNDNAPTFQSSVLRVGLPENTPPGTLLLRLNATDPDEGTNGQLDYSFGDHTSETVKNLFGLDPSSGAIHVLGPVDFEESNFYEIHARARDQGQPAMEGHCVIQVDVGDANDNPPEVLLASLVNPVLESTPVGTVVGLFNVRDRDSGRNGEVSLKTSPNLPFQIKPSENHYSLLTSQPLDREATSHYTIELLASDAGSPPLHTHLTLRLNISDVNDNAPHFTQQLYTAYIPENRPPGSLLCTVAASDPDEGDNARLTYSIVGSQIQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPRLHANTSLHVFVLDQNDNAPAVLHPRPGREFSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSAHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDAEEMPKSSDFLTHPPERSDLTLYLIVALAAVSLLSLVTFTFMSAKCLRRHEDGDRGGGHCCRGQDSPSREFYKQSSPNLQVSSDGTLKYMEVTLRPTDSQSHCYRTCFSPASDGSDFTFLRPLSVQQPSALALEPEALRSRSSTLRERSQVRAGSRHATPGRARWRSCPVHLRGVCSCTLFLFVPSWHTCWMRLKVDNQSG
Protein: E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187) (Q5TA31)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20852630}. Nucleus {ECO:0000269|PubMed:20852630}. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.
Interaction partners:
- Transcription factor Jun
Sequence:
MALPAGPAEAACALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPGRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADAGPLCAACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ
Protein: F-box only protein 34 (Q9NWN3)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Interaction partners:
- Cullin-1
- Unconventional myosin-VI
- S-phase kinase-associated protein 1
- F-box only protein 30
Sequence:
MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHITSSVFPSASLGKASSRKPFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEEGPLDIWAVVKPGNTKEKIAFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKVQVERMREVNSRCYQPEPFACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRASALLASCSKNCTNSPAIVRFSGQSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEPVRVLDMVAKLESECLKRQGQREPGSLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLEAPDTQVNPVGSVSVDCGPSRADRCSPKEDQAWDGASQDCPPLPAGVSFHIDSAELEPGSQTAVKNSNRYDVEMTDELVGLPFSSHTYSQASELPTDAVDCMSRELVSLTSRNPDQRKESLCISITVSKVDKDQPSILNSCEDPVPGMLFFLPPGQHLSDYSQLNESTTKESSEASQLEDAAGGDSASEEKSGSAEPFVLPASSVESTLPVLEASSWKKQVSHDFLETRFKIQQLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHRSQKGFPGCKLGLHDNHWVPACHSFNRAIHKKAKGTEAEEEY
Protein: Fgr51p (A0A1D8PH87)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Fgr3p
Sequence:
MNNYVIPGVKKLDISVCFDNDESHLYMFSPDLEDLRIYTERSMQVILPPNLRKLAIVTESYPISFISEEMVNLKHLSLLWPGMSSFEQTGIEAPNLETLILESINVADFTGLQNLEHLKQLEVVQSIFPIGLFNEGFPELEMLSFSDCIFPDFEDFNNSSLIFSSNLKELRIKNSGFSSVHFSNFVQPPTLKILDLDSLSFNYEHLGENLSYIHVRASKATLKSDFRIPPMTEKFTLNASYLTFESMDFMYHLPTNLASLHLSAKRSGKLYPITQMVEWPSKMSEINFKNFNIDYFKLKQLNLNESGLKKIYISGGDVKKLDAGLFPVSVKDLSLTEMGIQQLADSFENLENLQKLDLSGNQLRDIGPVKLPMASLQYLDVSQCNLRLISPFVVSMLEEKNKNAKLRVYAIDNVNVSVIDIRRVLKAIKGLSLVVSKFDKTLTEISKHSSRLHCQYTHVDHRIKQPEIDDLYNGSDSGSDEESSVTKNKRRKI
Protein: Protein N-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase) (Q8C436)
Organism: Mus musculus (Mouse)
Function: Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26544960}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- Histidine protein methyltransferase 1 homolog
- Electron transfer flavoprotein beta subunit lysine methyltransferase
- Protein-lysine N-methyltransferase EEF2KMT
- EEF1A lysine methyltransferase 2
Sequence:
MAAAVEPEVEDPLWSFVRVLEKRDGTVLRLQQYGSGGVGCVVWDAAIVLSKYLETPGFSGDGAHALSRRSVLELGSGTGAVGLMAATLGADVIVTDLEELQDLLKMNIDMNKHLVTGSVQAKVLKWGEDIEDLMSPDYILMADCIYYEESLEPLLKTLKDLSGSETCIICCYEQRTMGKNPEIEKKYFELLQLDFDFEEIPLDKHDEEYRSEDIHIVYIRKKKPKPPS
Protein: MYB-like transcription factor ODO1 (Protein ODORANT1) (PhODO1) (Q50EX6)
Organism: Petunia hybrida (Petunia)
Function: R2R3 MYB-type transcription factor controlling the production of volatile organic compounds (VOCs), including floral volatile benzenoids and phenylpropanoids (FVBP), in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26) by regulating the shikimate pathway, via the activation of several genes (e.g. EPSPS, ADT1, PAL1, CFAT and CCoAOMT1). This scent, mostly produced in the evening and night by the petals, attracts the pollinators (e.g. the night-active hawkmoth pollinator Manduca sexta). Promotes the expression of ABCG1 in petals three hours before the onset of volatile scent emission. Anthocyanins production is not controlled by ODO1 as color and scent are produced at different stages of development. Seems to trigger a negative feed-back loop that represses the expression of EOBI.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:22345641}.
Interaction partners:
Sequence:
MGRQPCCDKLGVKKGPWTAEEDKKLISFILTNGQCCWRAVPKLAGLKRCGKSCRLRWTNYLRPDLKRGLLSDAEEKLVIDLHSRLGNRWSKIAARLPGRTDNEIKNHWNTHIKKKLLKMGIDPVTHEPLKKEANLSDQPTTESDQNKENGHQQVQVVPQSTNVTAAAATSTEFDNNSSFSSSASSSENSSCTTDESKLVFDNLSENDPLLSCLLEADTPLIDSPWEFPMSSTTTVEEPKSFDSIISNMTSWEDTFNWLSGYQEFGINDFGFDNCFNHVELDIFKTIDNVENRHG
Protein: Retinal homeobox protein Rx1 (O42356)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
- Six3
- Neurogenic differentiation factor 1
- Sine oculis homeobox homolog 3a.
Sequence:
MHLSLDTMNMVDDSCLSPSNFHDMVKAGGAVVGTRVHSIDVILGFNKDQDSLLNPGDNAVAHKVGGESLGEPGKLDQRVQPYGHLPPLRDGSEQPTFHDADMFSNKCDGDLGDLRKAIESDSKSPDSADGEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKIDASTMKLHDSPMLSFNRPSMHPTVGPMNNSLPLDPWLPSPLSSATPVHSIPGFMGPTQGLQTGYPGHSFLSPPQPMAQSMQPMAPPPYQCPPPFTDKYPLEDVDQRSSSIAALRMKAKEHIQSMDKTWQPMC
Protein: SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) (Q0IIE2)
Organism: Bos taurus (Bovine)
Function: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P29353}.
Interaction partners:
- Growth factor receptor-bound protein 2
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Receptor protein-tyrosine kinase
- Tyrosine-protein kinase
- Receptor protein-tyrosine kinase
- Receptor protein-tyrosine kinase
- Receptor protein-tyrosine kinase
- SOS Ras/Rho guanine nucleotide exchange factor 2
- Tyrosine-protein kinase receptor
- Tyrosine-protein kinase receptor
Sequence:
MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPRLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGALPGAARPTPPSAQTPSHLGATLPVGQPAGGDPEARRQMPPPPPSSGRELFDDPSYVNVQNLDKARQAGAGAGPPNPTINGSAPRDLFDMKPFEDALRMPPPPQSTAMAEQLRGEPWFHGKLSRREAEALLQVNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Protein: Vacuolar membrane protease (EC 3.4.-.-) (FXNA-related family protease 1) (P38244)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in vacuolar sorting and osmoregulation.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:23679341}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Aminopeptidase Y
Sequence:
MKLKSVFRSVLKYRKTNLSLLLLITYSIITLLYIFDHERYKLNLPKEDEHPEFNDLLETAWGDLQIITASFHPYTSKENDKVHDYLLKRVLEITGNSSFASVSDDKESERSILFQQQDPFNESSRFSRVTYFESSNILVKLEGKNPEEEGLLLSAHFDSVPTGYGATDDGMGVVSLLANLKYHIKHRPNRTLIFNFNNNEEFGLLGASTYFDHSWSNLTKYVINLEGTGAGGKAVLFRTSDTSTARIYQQSVKENPFGNSIYQQGFYSRYVRSETDYKIYEENGMRGWDVAFYKPRNLYHTIKDSIQYTSKASLWHMLHTSLQLSAYVASNSLDTADQTPACYFDFIGLKFFVISAKTLFYWNCIFLLVSPVVAIGLYLISRDRMTWKSYSWLSWTRFPLSLAAGIIVQKLFSNDIIRSNPLTFSRNYFWPISAFFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWTILLFTSKLLYSSDYRYTGLYPLSIFFLLSTIAAILRLLALALGMRTRKRLGRECRDHHSNYSSHSQIDMERDGQENLEQPQDQLTSSQDDQASIQDDNVSTTSAGPSHNVDEDHGMDSSSQQHDERVPLLKGSNSMEEGLSTRENSLKLEYTDYAWIIQFLLIVPIPSFILFNSVDVIMDALNHTVQEGSKATFDVLRFGMVGSILIALPILPFFYKVNYITISLTALLFLISASKTLLVHPFTNSNPLKVRFSQNIDLSQGNAASVHVLGREGNFLKPMLQDLPSIKYSSTHINCTSVTNGMELCMYDGMQPNLLSTNGNTNISSMVKVHVLHNNRNSTERSPYEPIVAELLLEVKENRACTLTFESRHQAKSPVREITVYQKKNSAPQKANITKTIKSASGINELQLHKLDFDQETYHIGVQWFPKLLTDGNVEDDKLGTKDELSVSISCYWGEYDSESVVNGTAVRKIPAFDELINYAPLSFSFTNEQKGLVIVKDAIIL
Protein: Nuclear factor 1 (A0A0A0MRX8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MERIPVSVDFWVVCCAVLKCNPGIPKRMSTLCFGFSDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG
Protein: Tryptophan RNA-binding attenuator protein-like protein (Q84J77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Altered inheritance of mitochondria protein
- Calcium-dependent lipid-binding
- Large ribosomal subunit protein eL15y
- Derlin-2.1
- Derlin-2.2
- Jacalin-related lectin 34
- E3 ubiquitin ligase PARAQUAT TOLERANCE 3
- ERAD-associated E3 ubiquitin-protein ligase HRD1B
- Tryptophan RNA-binding attenuator protein-like protein
- ERAD-associated E3 ubiquitin-protein ligase component HRD3A
Sequence:
MAAPFFSTPFQPYVYQSQEDTITPFQILGGEAQVVQIMLKPQEKVIAKPGSMCYMSGSIEMDNTYTPEQEVGVVQWILGKSVSSIVLRNTGQNDGFVGIAAPSLARILPLDLAMFGGDILCQPDAFLCSVHDVKVVNTVYQRHRARNIAAAGAEGVLRQRLSGQGLAFIIAGGSVVQKNLEVGEVLTIDVSCIAALTPSINFQIKYNAAPVRRAVFGGDNVVTATLTGPGIVFIQSLPFHRLSQRIARSVTSPNMRENPRLLVQIGLFIFLAYVVIVSSLILTEM
Protein: Cytochrome c (P67881)
Organism: Gallus gallus (Chicken)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Interaction partners:
- Apoptotic protease-activating factor 1
- Caspase 9
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Caspase-3
- Apoptosis regulator Bcl-2
- Cytochrome c oxidase subunit 1
- Bcl-2-like protein 1
- Bcl-2 homologous antagonist/killer
- Caspase-8
- Myoglobin
Sequence:
MGDIEKGKKIFVQKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAEGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKSERVDLIAYLKDATSK
Protein: Gap junction alpha-8 protein (Connexin-49) (Cx49) (Lens fiber protein MP70) (MP38) (MP64) (P55917)
Organism: Ovis aries (Sheep)
Function: Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30542154}; Multi-pass membrane protein {ECO:0000269|PubMed:30542154}. Cell junction, gap junction {ECO:0000269|PubMed:30542154}.
Interaction partners:
- Filensin
- Beta-crystallin B2
- Gap junction beta-2 protein
- IF rod domain-containing protein
- CWF19-like protein 2
- Alpha-crystallin A chain
- Beta/gamma crystallin 'Greek key' domain-containing protein
- Beta-crystallin B1
- Homeobox protein
- Otopetrin 2
Sequence:
MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLVYVGHAVHHVRMEEKRKEREAEELSQQSPGNGGERAPLAADQGSVKKSSSSSKGTKKFRLEGTLLRTYVCHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNILEMSHLGLKKIRSAFKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVEASPLSAKPFSQFEEKVGPGPLGDLSRAYQETLPSYAQVGAQEGVEEEQPIEAAAEPEVGDKSQEAERVSTEGEETLAVLEEEKVEPPEVEKEAEKEETPPEKVSKQELTPEKAPSLCAELPGEDTRPLSRLSKASSRARSDDLTV
Protein: Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (S-Lac lectin 1) (P16045)
Organism: Mus musculus (Mouse)
Function: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P09382}. Cytoplasm {ECO:0000250|UniProtKB:P09382}. Secreted {ECO:0000250|UniProtKB:P09382}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P09382}.
Interaction partners:
- Galectin-3
- Receptor-type tyrosine-protein phosphatase C
- Annexin A2
- Vimentin
- Laminin subunit gamma-1
- Galectin-2
- Protein S100-A4
- Protein S100-A6
- Epithelial membrane protein 3
- Annexin A5
Sequence:
MACGLVASNLNLKPGECLKVRGEVASDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNTKEDGTWGTEHREPAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE
Protein: DNA polymerase epsilon catalytic subunit (EC 2.7.7.7) (Q38DX2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365029}.
Interaction partners:
- Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
- DNA polymerase II subunit 2
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- Cell division cycle 45
- DNA replication licensing factor MCM3
- Chromosome transmission fidelity protein 18 homolog
- DNA primase large subunit
- DNA polymerase
- DNA replication complex GINS protein SLD5
Sequence:
MNCSVQMPPPQDEWPIMESGTRTGWLFNYHPTSVAAPESAFDRHGGSGVRAALVLLFTDHEREVFQVNLFYNPYIFVSAVEGHEHEVELGMMSLFGPQLICHIEIVEKEDLDLINHLSGRKRLYLKVSFSNVQDLTTVRGRLEKIVKRNASMGASNTLLNPLDRSIGDVMAKTFEDDPVNSTTASERWFDWVHEIREYDVKYSMRVGIDLGVFVGLWYDVKVHEGETQLIRCDLNAYAPAMPRVCAFDIETTKAPLKFPQPEVDQIYMISYVLDGRGYLIVNREIVATDIHQFEYTPKPEYEGIFDTFNEPDEKALLQRFYSEMRLYQPTVYVTYNGDYFDFPFIHARSLFHHLSMREELGFSQNSEGAFVANKLVHLDCFYWVKRDSYLPQGSQGLKAVTKYKLGYEPIEVDPEDMLPLAQSNPQQMASYSVSDALSTWFLYQKYVHPFIYSLSTIIPMAPDDVLRKGSGGLCESLLMVQAYANNVIFPNKKEIKLERFFNGHLIDSETYIGGRVEALRSGVYRSDIPIHFQMSADMYQKLIDDLDDALRFSLEVENSVKMNEVTNYEEIRDSIKARLEVLRDRPSQYATPIIYHLDVGAMYPNIILTNRLQPYAIPKAEVCAGCCFNSPTNEHFCKRTMAWKWKGEFLTAGRHEYQRVKAQLENESFAESVIQQANLSAVQKKTYGNRKDNVLEGTAYEKKRRPFAKRQNDVKSDYRHENNFQRQEARNALLHKEFQKDQDGSGSDEDEDAGGPKAYYKLQESTKFNMLKKRLAEYSRKAYGKIHESREIMRSDVVCQRENSFYVDTVRLFRDRRYEYKAALKTWKKRLDNAKDTEEIKLCKSRCVQMESLQLAHKCILNSFYGYVMRKGSRWYSMEMAGIVTYLGATLIQMARALVQQIGVTLELDTDGIWCCLPNTFPENFTFTTTNPSTPKVTISYPCIVLNKMVHDGYTNHQYQTCVGPGLYERRSECSIYFEVDGPYLAMMLPASREEGKGIKKRYAVFDPDGRLADLKGFELKRRGELMLIKDFQSQVFRRFLDGTTLVESYASAAVAANVALDMLYSKGEGYDPEEILEKLSESSNMTRRLSEYPDSQKSLALTTARRIGDFLGPQMVKDKGLACQFVISRLPSGRPVTERAIPLTIFRADPAIRTHFLRKWTGDNSISANVDLQHLLDWDYYIARYNACVQKIITIPAALQQVPNPVPRVPYPDWLQKRVQQLNSRFKQTTLTNMFVKAKPGDGGVPDVEDLVTGDGVAPSSGGEKDVRRKKNGSAGVVNGDVYYLQESEGTDSDVASIVNVSDDEGYRLVREAELHEIEDVEMLKSKYFAPNSNHPMDAAFFADARVGAWLKLQKQAWTRRATLRRQMMKESELLTADGQPTSSHFIDVKTKALSTTWHIMEIRTDKADDGTVAVIAALDKTLYTFRCIVPRRIVVDADHNAFLPSAKPVTNALVLPRSRSSTNLLHVDLPPGREGERMLNGLLTGREDVHMVYEDHITRAEVMIEKIGCCANVLVDDYLRNARQRPYARGTFSVDELTSVPTGNYLQNSSNRFVFLFHVASDTRGIIGLVNHFDHTAFVAIIQPASAPAPTINWRTLFFEAAQSLNSTEVPLDVTWEVVADTENAWRLVYRSLNGVMEGGGSPLFAVLESSITTTQLIEQRCLPSSLPYLRILGAAEDERLLSDPFRWTRLLARRLLQRYCASLLWVEERISFSRLSRIPLCNLMQDTSVHAWDVLFTRALHARAHVLWNSRDVSIAFDSIEERPRQVVMPGGYLSWGVEFSLARLDVVAVLFSQLIQEGDDPNAHALCNQGVTTHFNILRDLVSDLLGQVRTNAVADVLLASFSRWIRDPVSSCYEPRLLELVSTLAHRALTTVLFSLAKLGGRTVKVDGDSIVVLTPKHTIQDTVSFARFMVDSLKDQPMLLLLSLKPIRYWCPFVILDKRDYVFLYVTSEGCKSLKEKDQVVLDEMLVEYSFTIWSKLPKKVRDILLVRIEGTLRAIALARESVLVEVQEDPTVVLATKNEQILTRIVGVYKKLVEGKLHTELIEEVHDLTERKDLHEKGFPAGETTLTGAAVALEYTKVVCRLLELFPNDGVLGKVRNNCLRLCGVSPFSPLAQITADADTDCHQLMFQCSFCNADVLLDLSIREKRMRCNGCSAPIFASAVESYLVRKVNTLVMSYTKQDFVCGKCHEVTANSINQTCCGPLVGKAKPIHTQLQALKKVAVIQGFAWLEECVETALQFS
Protein: Missing-in-metastasis, isoform K (A0A0B4KEU9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDLSLERDSSALGSLFQQIINDMKNTSPLWEDFVAKAGKLHTCLRAAIQAIAAYLDAFQKIADAATNSRGASKEIGTALTRVCLRHKAVETRLKTFTSTIMDCLVQPLQERIEDWKRTVATIDKDHAKEYKRCRSELKKRSSDTLRLQKKARKGQTDGLQSLMDSHMQDVTLRRAELEEVEKKSLRAAMVEERLRYCSFVHMLQPVVHEECEVMSELGHLQEAMQSIALVTKEPSVLPQASEELIHDAKASINLYPESPGGGSGSQGGGCSNSLGSRKSSVCSISSMNSSGSSNSPGHHHYPRSLSQFVTPAIRLKPGESSDSGFCSSPALTTQTSNATNQTANVSTWPPHSQDGVDTLPPTADRPHTISTAYEKGHQRPPLTVYTFQNPETIHESGSCLNNGTAAPNGQPLSGQATPATQKSPAASLSRPPLPVRCSSLERPLSAQSNHRQGSGNNLLQRQCPSPIPAHITKGGAAGGGSTRIGRRSSINQSKPPPPVRRSSSVTPSPNASVGLQQQPQHATLSQQNHQLSSSSEHLPPPPPFMLDAMPQIPSSALKVSETVRALAAMRHQPASPVSLRRMQQQQQQQLQQQQQQQVQQQQPLLQSAHNSPLKEDLTVYYDSYLDLHAYAQALASGQQPGGQQMANQQRFTLQQQHQHLHQPQQPPVYQVDATFRTSSPAAGGGGGGGIYAQPKLVNSMSSFRTSSPSPNGHAHPLPPTQPKANPNLIAQLNARLSGKQQQHQQQQHIEGIYGNQQAPGGESIYMRSGLSMSQPQQQQHFDAGPSHLSRIADGSNQARSHLKA
Protein: SP2353 (Q9NGV2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSTSKHHHHHCRVVCVWLLLVLSSLSSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYEIHDGMYECDCIEGYELNKNGYSCQVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPADNENGEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAICLCPIGFVGDLCEIRMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGEMKLNFDPNTLGTEHNVETGLL
Protein: Type 1-like ryanodine receptor (O75591)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHL
Protein: AT4g19390/T5K18_170 (Q94JM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA-binding protein-like protein
- Uncharacterized protein At4g31330
- RING-H2 finger protein ATL57
- Probable serine/threonine-protein kinase PBL21
- Ran-binding protein M homolog
- Succinate-semialdehyde dehydrogenase, mitochondrial
- Phospholipase A
- Allantoate deiminase
- Late embryogenesis abundant protein 31
- NADP-dependent malic enzyme 1
Sequence:
MTTPCRTINANAIAAPSPSGLIFNGFRDFVPIEKRLVISSFRGLKLPSRTTKTITSSDWSWSYRSPGRLASASTSTSASTSTSAAVTSNSTNRFEALEEGIEKVIYSCRFMTFLGTLGSLLGSVLCFIKGCMYVVDSFLQYSVNRGKVIFLLVEAIDIYLLGTVMLVFGLGLYELFISNLDTSESRTHDIVSNRSSLFGMFTLKERPQWLEVKSVSELKTKLGHVIVMLLLIGLFDKSKRVVITSVTDLLCISVSIFFSSACLFLLSRLNGSH
Protein: Protein transport protein SFT1 (P14) (P43682)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Vesicle SNARE required for retrograde transport within the Golgi complex.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:7596416}; Single-pass type IV membrane protein {ECO:0000269|PubMed:7596416}.
Interaction partners:
- Syntaxin PEP12
- Protein transport protein SEC22
- Integral membrane protein SED5
- Golgi SNAP receptor complex member 1
- Syntaxin VAM3
- Synaptobrevin homolog YKT6
- Protein SLY1
- Protein transport protein BOS1
- Protein transport protein BET1
- t-SNARE VTI1
Sequence:
MSNSRYSQTESNNDRKLEGLANKLATFRNINQEIGDRAVSDSSVINQMTDSLGSMFTDIKNSSSRLTRSLKAGNSIWRMVGLALLIFFILYTLFKLF
Protein: Elongation factor RNA polymerase II (RNA polymerase II elongation factor ELL) (Q6PEG4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAALKEEQCYGLSCGRVSNGSKISVYHVKLTDSALRAFEDYQSNKGLTAKPLIGFTGSQGKISIPQSENPNELRTFTFYLSNVGKDNPQGSFDCIQQYITSEGSIQLDCLGGIQDKITVCATDDSYQKARQSMAQVEEETRSRGAIVIKPGGRYVGKRVQIRKPITGVSDVAPSRRTSRPVIISSSAQKKSPPRPLRERLVHLLALKPYRKPELLVRLTKDGLSFQDKETLDSLLQQVANLNSKDNTFTLKDCLFKEVQKDWPGYTEVDQQILKRILVRKLCKPQSNAPVSVESPVSPHKEPASSSPSQLNTHNPQKRPAADFIDPLANKKPRISHLVSKSTGLINGKLSSSNGKDTSSSQATETSSSSQFPPLEIPRPFDPLSDVSNDSNGRDCEGQEAAVAERLSQPPSFAPRSATQEERQTSMSPPHSSLDSSLTQTTQPSLHGKSKKKSKKHKDKDKSKDKDRDRERDAKKERRVDEERGLDQRKPCDVTTSDKSTGLNGTCNSSSIPASSSETADYLIKYTVISSPEQRQTYKNDFNSEYSEYRGLHARIESITRQFTILDSELKQLQQGTDKYKTIHNQILEEYRKIKKTNPNYSQEKNRCEYLHNKLAHIKKLIAEYDQQQLQNWH