wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription initiation factor TFIID subunit 3 (TAFII-47) (TAFII47) (TBP-associated factor 3) (TBP-associated factor 47 kDa) (Q12297)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcription initiation factor TFIID subunit 8
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 7
- SAGA complex/transcription factor TFIID complex subunit TAF6
- Transcription initiation factor TFIID subunit 14
- Transcription initiation factor TFIID subunit 4
- SAGA complex/transcription factor TFIID complex subunit TAF5
- SAGA complex/transcription factor TFIID complex subunit TAF12
- SAGA complex/transcription factor TFIID complex subunit TAF10
- Transcription initiation factor TFIID subunit 1
Sequence:
MTTNNDFYFALLRISILQLLKAQGFDRARPSLVDVMTDLYAKFLSLLASEVSSIAQARCDQDDTIALQDITLALENLGIVKPTNVLDVYDENSELSSSRGMEKFKDWCIYSTQLTDARITALPTVELLQSEEKESDPLSAIPDYLNQLLQNKGAKQKLETKNRKTELIEDLINNNGLDDWIKLVIARQRINMIERASKKESQNVPALPHIAGYKSSILSRHHHTTITNEDRMPSAMTPRDEDALTEIQENPFVTSKLPIMRKENRLENITLSFEDEELESLGEVEGPNQKSQENNNEESFKENNKSLTESPHGDDRDISMFQFDSNVDTKWAEQEDMDSTFQRRTSLDYGGYF
Protein: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (N-acetylglucosamine-1-phosphate transferase) (Q6P4Z8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- UDP-N-acetylglucosamine transferase subunit ALG14
- UDP-N-acetylglucosamine transferase subunit ALG13
- ALG5, dolichyl-phosphate beta-glucosyltransferase.
- Dolichol-phosphate mannosyltransferase subunit 1
- dolichol kinase
- Dolichol-phosphate mannosyltransferase subunit 3
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- GDP-Man:Man
- Dol-P-Man:Man
Sequence:
MWAFPELPLPLPLLVNLIGSLLGFVATVTLIPAFRSHFIAARLCGQDLNKLSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDYRDDHVFSLYFMMPFFFTTLGLLYHNWYPSQVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLFQIIPCPRHRMPRLNTKTGKLEMSYSKFKTKSLSFLGTFILKVAESLRLVTVHRGESEDGAFTECNNMTLINLLLKVFGPTHERNLTLFLLLLQVLSSAVTFSIRYQLVRLFYDV
Protein: COP9 signalosome complex subunit 1b (Dch1-2) (Signalosome subunit 1b) (Q9VVU5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:10531038}. Nucleus {ECO:0000305|PubMed:10531038}.
Interaction partners:
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 7
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 2
- Ubiquitin-like protein NEDD8
- DNA damage-binding protein 1
- Cullin-4A
Sequence:
MPVLPMPPLMQNAVEPMQVDIAPPNEDNENNEEQQIVVENPSIDLEVYANQYAGIVRLHRLIYVADVCPVLAVEALKMAITYVQTTYNVNLYQVLHKRLSDLNAGNAPAPPANAGGDQAGAAAPGPLAAAPLPDIAAQPVAQAQGQAQPAVEKDAFAYDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADHYLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAEGSKEANAQVHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATFDRQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYTKIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQRNSTFERALIMGKQYQRHTRMLVLRAAMLKSHIHVKSISREGGSNHGAELCVSAGSSTTAQLARI
Protein: Beta-crystallin A2 (Beta-A2 crystallin) (Q9JJV1)
Organism: Mus musculus (Mouse)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Alpha-crystallin A chain
- Filensin
- Alpha-crystallin B chain
Sequence:
MSSAPAPGSAPVCLTLWDEEDFQGRRCRLLSDCANVCERGALRRVRSVKVENGAWVAFEYPDFQGQQFILEKGDYPCWSAWSGSSGHHSNQLLSFRPVLCANHSDSRVTLFEGENFQGCKFELSDDYPSLPSMGWTSKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFRTYSDFGTQAHTGQLQSIRRVQH
Protein: Testis-specific gene 10 protein (Cp431) (Q9Z220)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in spermatogenesis (By similarity). When overexpressed, prevents nuclear localization of HIF1A (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14585816, ECO:0000269|PubMed:16643851}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9BZW7}. Note=In mature spermatozoa, localizes to the centriole and midpiece (By similarity). The 27-kDa N-terminal fragment associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa fragment localizes to the midpiece (PubMed:14585816). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (PubMed:16643851). {ECO:0000250|UniProtKB:Q9BZW7, ECO:0000269|PubMed:14585816, ECO:0000269|PubMed:16643851}.
Interaction partners:
- Intersectin 2
- Intersectin-1
Sequence:
MMRNRSKSPRRPSPTSRAANCDVDLLKSTARDREELKCMLEKYERHLAEIQGNVKVLTSVRDKTFLLYEQAQEEIARLRREMMKSCQSPKSTTAHAILRRVETERDVAFTDLRRMTTARDSLRERLKIAQAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETITIVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGATLNDLAKEKECLQTCLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQSTEALIMCEQDISRMRRQLDETNDELGQIARERDILAHENDNLQEQFAKVKQENQALSKKLNDTHNELSDIKQKVQDTNLEVNKLKNILKSEESTNLEVNKLKNILKSEESENRQIMEQLRKANEDAENWENKARQLEAENNTLKLELITAEAEGNRLKEKVDALNREVEQHLNAERSYKSQIATLHKSLVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMMENELDSARSEIELLRSQMTNERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHLGSMKPNTKCHSPERAHHRSPDRDLDRSLEENLCYRDF
Protein: Large ribosomal subunit protein uL4y (60S ribosomal protein L4-2) (L1) (P49691)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS6y
- Large ribosomal subunit protein uL1y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL24y
- Small ribosomal subunit protein eS28x
- Large ribosomal subunit protein eL8z
- Small ribosomal subunit protein eS24y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL23z
- Small ribosomal subunit protein eS6z
Sequence:
MVASAAARPLVTVQGLDGDMSTDQSTTVTLPDVMTAPVRPDIVNFVHAQISNNSRQPYAVSKKAGHQTSAESWGTGRAVSRIPRVPGGGTHRAGQAAFGNMCRGGRMFAPTKIWRRWHRRVNVNMKRHAIVSAIAATAVPALVMARGHKIENVPEMPLVVSDSAEAVEKTSAAIKVLKQIGAYDDAEKAKNSIGIRPGKGKMRNRRYISRKGPLVVFGTEGAKIVKAFRNLPGVELCHVERLNLLKLAPGGHLGRFVIWTKSAFEKLESIYGSFEKPSEKKKGYVLPRAKMVNADLARIINSDEVQSVVNPIKDGSKRAVLKKNPLKNLNVMFKLNPYAKTAKRMSLLAEASRVKAKKEKLEKKRKVVTKEEAQAIKAAGKAWYQTMISDSDYTEFDNFTKWLGASQ
Protein: Probable 26S proteasome non-ATPase regulatory subunit 9 (Q10920)
Organism: Caenorhabditis elegans
Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
Interaction partners:
- Probable 26S proteasome regulatory subunit 10B
- 26S protease regulatory subunit 6A
- 26S proteasome non-ATPase regulatory subunit 1
- Probable 26S proteasome regulatory subunit 6B
- Probable 26S proteasome regulatory subunit 4
- 26S proteasome regulatory subunit 7
- Proteasome subunit beta type-2
- PCI domain-containing protein
- AAA+ ATPase domain-containing protein
- 26S proteasome regulatory subunit 8
Sequence:
MDHHSKAKELLQQRDELDGKIKELMLVLETNNSTMDSPLLDAEGYPLNTIDVYAVRHARHDLICLRNDRAALTEKIVVEMENENKEVSGQTATSEEKPVHRTSNEPFVKISSVVELSPADIGGFRKDDLIIQYGNLHHGNFNDMQEVAQITKQSEDKIIRVTVIRENRPVRLEICPKKWSGPGLLGCNIVPISGANV
Protein: Solute carrier family 8 member 1a (A0A286YBI0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGQSGTSSYFSLALNLSIFLLVFSYELTPVIAGSSKSSLDVDTSNANSSQETCGGSYECKEGVILPIWTPVNPSFGDKLARATVYFVGLFYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTTTTVRIWNETVSNLTLMALGSSAPEILLSVVEVCGHNFDAGELGPNTIVGSAAFNMFVIIGLCVSVIPEGEHRKVKHLRVFFVTATWSIFAYTWLYLILAVISPGIVEVWEGLLTLFFFPICVLFAWVADRRLLFYKYVYKRYRVGKKRGIIIETEGEPELQSKADIEMDGGMLNSHAEEFLDGAVDNEDKDADEDEARREMAKILKELKQKHPEKEMEQLVELANYHVLSQQQKSRAFYRCQATRLMTGAGNILKKHAADQARKALGIHELRSEVSDNDISSKIFFDPGTYQCLENCGTVALNVVRRGGDLTSTVSVEYRTEDGTANAGSDYQFTEGVIIFKPGETEKEIRVDIIDDDIFEEDEHFLVHLSNVKVISEGANNGNPGTNHVDALAGLGLPSTATVTIFDDDHAGIFLFEEPIVHISESIGMMEVKVVRTSGARGVVVIPYKTIEGTAKGGGEDFEDTHGVLEFQNDEISKTIQINIIDDEEYEKNKNFFLEIGEPQLVEMSERKEDGEEETLTKKEKDERRIAEMGRPTLGEHVKLEVIIEESYEFKSTVDKLIKKTNLALLVGTNSWRDQFVEAITVNSGDDDDEECGQEKMPSCFDYVMHFLTVFWKVLFAFVPPTDYWNGWACFIVSIMMIGVLTAFIGDIASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIFHQSQGRQFRVDPGTLAFSVTLFTIFAFVCIAVLMYRRRPEIGGELGGPRHPKIITTTLFFSLWLMYIILSSMEAYCIIKGF
Protein: 3-oxosteroid 1-dehydrogenase (EC 1.3.99.4) (3-keto-Delta(4)-steroid Delta(1)-dehydrogenase) (KSDD) (3-oxo-Delta(4)-steroid 1-dehydrogenase) (KSTD) (P71864)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the degradation of cholesterol. Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Has a clear preference for 3-ketosteroids with a saturated A-ring, displaying highest activity on 5alpha-AD (5alpha-androstane-3,17-dione) and 5alpha-T (5alpha-testosterone, also known as 17beta-hydroxy-5alpha-androstane-3-one). Is also involved in the formation of 3-keto-1,4-diene-steroid from 3-keto-4-ene-steroid. Catalyzes the conversion of 3-oxo-23,24-bisnorchol-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) to 3-oxo-23,24-bisnorchola-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA).
Interaction partners:
- 3-ketosteroid-9-alpha-monooxygenase, oxygenase component
- 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
- Enoyl-CoA hydratase ChsH3
- Succinate dehydrogenase 2 membrane subunit SdhC
- Iron-dependent extradiol dioxygenase
- Possible flavoprotein
- Conserved protein
- Flavin-dependent monooxygenase, oxygenase subunit HsaA-triene-9,17-dione 4-hydroxylase, oxygenase subunit)-triene-9,17-dione monooxygenase)
- Multifunctional 2-oxoglutarate metabolism enzyme
- 4-hydroxy-2-oxohexanoate aldolase
Sequence:
MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR
Protein: COMPASS component SWD1 (Complex proteins associated with SET1 protein SWD1) (Set1C component SWD1) (P39706)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:15282802}. Chromosome, telomere {ECO:0000269|PubMed:15282802}.
Interaction partners:
- COMPASS component SWD3
- COMPASS component SHG1
- COMPASS component SPP1
- COMPASS component BRE2
- COMPASS component SDC1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- COMPASS component SWD2
- Polyadenylation factor subunit 2
- Polyubiquitin
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MNILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTIPTDYTRIIKMQSS
Protein: Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4) (Q96EI5)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription elongation factor A protein-like 1
- Ubiquitin carboxyl-terminal hydrolase 7
- Transcription elongation factor A protein-like 2
- Transcription elongation factor A protein-like 3
Sequence:
MEKLYSENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGKTGDEEMLKDKGKPESEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPGSETRAAGKRPAEDDVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNEDMIREFDNMAKVQDEKRKSKQKLGAFLWMQRNLQDPFYPRGPREFRGGCRAPRRDIEDIPYV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9W3Y1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein chiffon
- DNA replication licensing factor Mcm5
- DNA replication licensing factor Mcm3
- Protein MCM10 homolog
- CDC45L
- DNA replication licensing factor Mcm6
- DNA replication licensing factor Mcm2
- Cell division control protein
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm7
Sequence:
MADRVMCQELATPGSHYRRPKTGVPSTNVVYANGGGSWRAAPRQTQRLPRQTVQQYATGTPATGSAGRHSGRAFATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLGTLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEESNKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANNAKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFNCLCEDSDYLTEPLDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFFTAAEEAEQTEQDQLANGTPRKMRRQRYQSHRTVAASQEQVKQQVALDLQQAAINKL
Protein: LD34181p (Stromalin) (Q9VM62)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
- Structural maintenance of chromosomes protein
- FI11703p
- Structural maintenance of chromosomes protein
- Precocious dissociation of sisters 5, isoform A
- Nipped-B protein
- Protein wings apart-like
- MAU2 chromatid cohesion factor homolog
- separase
- Structural maintenance of chromosomes protein
- GH12158p
Sequence:
MMARRGGKRIRMDDPPPDYEELHSDALNESTSDADSPTKRMTRLRARGGVRDKPPIIDDDEDDFFAPIARKRKTPATRKGPTERKERVERPRKEPVDKGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSRDRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAEFLNVRLFHLTADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFIDSNDMVRDWECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHTGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYNITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQYVENECESVNVTEVVAELRNNLDTFMGACFELTRDGPTVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLILDNFVQHYVFSLKQDVAQDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINKVNFAMTLLLSLITVFKSLQEQSEDGIVSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHRGGIYFAANKEPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPLILYRNSLLHGETDQAPVASKRAYTRKRRDHDEEEEEEEDEEEHNDPDYRG
Protein: Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (O42202)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q64289}. Nucleus {ECO:0000250|UniProtKB:Q64289, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Paired box protein Pax-6
- Insulin gene enhancer protein isl-1
- Paired box 4.
- Homeobox protein Nkx-2.2a
- ELAV-like protein
- NK6 homeobox 1.
- Nuclear receptor subfamily 2, group E, member 3.
- Cone-rod homeobox
- Transcription factor Sox-2
- Transcription factor HES-5
Sequence:
MTKSYSEESMMLESQSSSNWTDKCHSSSQDERDVDKTSEPMLNDMEDDDDAGLNRLEDEDDEEEEEEEEDGDDTKPKRRGPKKKKMTKARMQRFKMRRMKANARERNRMHGLNDALESLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLMSFVQALCKGLSQPTTNLVAGCLQLNPRTFLPEQSQEMPPHMQTASASFSALPYSYQTPGLPSPPYGTMDSSHIFHVKPHAYGSALEPFFDTTLTDCTSPSFDGPLSPPLSVNGNFSFKHEPSSEFEKNYAFTMHYQAAGLAGAQGHAASLYAGSTQRCDIPMENIMSYDGHSHHERVMNAQLNAIFHDS
Protein: GOLD domain-containing protein (Q38A47)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKSFRVVCRFPAMLQLLALVGLALVPQSALSSQNGVYVKLFPGRELCLSYEGYREVEETPPTVALRHRALSPRNVNVRTRLYGPDGNIIRHDDRIDPFGQPASFFFKVTKTGTYRVCMRTPLNHPPLSFDMRFIGERDVAQSPETVEGVEVADKPIEASDYQSSLHMLDICVQVALDEVRMSENRLHLLDEITNSTYNRVVGFLILNVLLVIVASVGSEKYLERFFIKQKIA
Protein: Muscle, skeletal receptor tyrosine-protein kinase isoform 3 precursor (EC 2.7.10.1) (Muscle, skeletal, receptor tyrosine kinase) (Novel protein) (Q8JFU3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Docking protein 7.
- Agrin
- 43 kDa receptor-associated protein of the synapse
- Protein Wnt
- Acetylcholinesterase collagenic tail peptide isoform X2 of asymmetric acetylcholinesterase)
- Low density lipoprotein receptor-related protein 4
- Acetylcholinesterase
- Acetylcholine receptor subunit epsilon precursor
- IRS-type PTB domain-containing protein.
- TXK tyrosine kinase
Sequence:
MKVPKNTPLVVFLAFFSLTEGLQRAPRITTLLETVDSSLDHNATFICEVDSYPQADIIWTRNNYPIRYYDSRYVIQENGQMLIIPNVKDSDSGEYCCIANNGVGEAKSCGALQLKMKPQIKRHPTNMTLILESKAVLPCLSLGYPKPEISWIKEDDLIKANNRIAILESGSLKITNIKKEDAGQYRCVARNSFGIAFSRPVTIEVQAPAKILKVPKEKRVQIGSEVTLECNATGNPIPSITWLENGNTVILYFITYFQSFLILSHSLLFLLLALALQRKLIVLSSHLTGTESRAQDIHVKCQTANLKLPASTITGGLRSVNASLGATINRIQTTIIPQSADRATAIKFKPY
Protein: Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) (Q8H0V3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Interaction partners:
- Hydroxyacylglutathione hydrolase 2, mitochondrial
- Probable hydroxyacylglutathione hydrolase 2, chloroplastic
- Hydroxyacylglutathione hydrolase 1, mitochondrial
- Hydroxyacylglutathione hydrolase cytoplasmic
- Protein DJ-1 homolog D
- DJ-1 protein homolog E
- DJ-1 protein homolog F
- Persulfide dioxygenase ETHE1 homolog, mitochondrial
- Lactoylglutathione lyase GLX1
- Probable lactoylglutathione lyase, chloroplastic
Sequence:
MASEARESPANNPGLSTNRDEATKGYIMQQTMFRIKDPKASLDFYSRVLGMSLLKRLDFSEMKFSLYFLGYEDTTTAPTDPTERTVWTFGQPATIELTHNWGTESDPEFKGYHNGNSEPRGFGHIGVTVDDVHKACERFEELGVEFAKKPNDGKMKNIAFIKDPDGYWIEIFDLKTIGTTTVNAA
Protein: Deoxyhypusine hydroxylase (DOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (Q99LN9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Interaction partners:
- Eukaryotic translation initiation factor 5A-1
- Deoxyhypusine synthase
- Eukaryotic translation initiation factor 5A-2
Sequence:
MVTEQEIEAIGKTLVDPKQPLQARFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDARAIPVLADVLQDTSQEPMVRHEAGEALGAIGNPEVLGLLKQYSTDPVVEVAETCQLAVGRLEWLQQHPGEATCAGPYLSVDPAPPAAEQDVGRLREALLDEARPLFERYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLARTTESPMVRHECAEALGAIARPACLAALREHIEDPEQVVRESCEVALDMYEYESSQDFQYADGLERLRPPP
Protein: Diglucosylglycerate octanoyltransferase (DGG octanoyltransferase) (EC 2.3.1.273) (A0R109)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.
Interaction partners:
- DegV family protein
- Phosphoglycerate mutase family protein
- Probable nicotinate-nucleotide adenylyltransferase
- Ribosomal silencing factor RsfS
- Octanoyltransferase
- Probable S-adenosylmethionine-dependent methyltransferase MSMEG_2350/MSMEI_2290
- 1,4-alpha-glucan branching enzyme
- Hexapeptide transferase family protein
- Polyketide cyclase / dehydrase and lipid transport
- Uncharacterized protein
Sequence:
MSSETSSESTGHRPVLLVFADSLSYFGPTGGLPADDPRIWPNIVGEQLGWDVELIGRIGWTCRDVWWAATQDPRSWAALPRAGAVVFATSGMDSLPSPLPTALREMIRYVRPPWLRRWVRDGYGWVQPRLSPIARSALPPHVTVEYLEMTRNAIDFNRPGIPVVASLPSVHIAETYGRAHHGREPTVRAITAWAEEHHVPLVDLKAAVADEVFGGRGNPDGIHWSFEAHRAVAELMLKGLAEAGVTQRDSAT
Protein: G-protein coupled receptor 15 (Brother of Bonzo) (BoB) (P49685)
Organism: Homo sapiens (Human)
Function: Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Protein GPR15LG
Sequence:
MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELTLIDDKPYCAEKKATPIKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAHYQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRQEHYLPSAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETSDSHLTKALSTFIHAEDFARRRKRSVSL