wanglab/gogpt-training-data huggingface dataset:
Protein: ECF RNA polymerase sigma factor SigG (ECF sigma factor SigG) (Alternative RNA polymerase sigma factor SigG) (RNA polymerase sigma-G factor) (Sigma-g factor) (P9WGG5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein. May be involved in host intracellular survival after infection (strains H37Rv and CDC 1551). A role in the SOS response is controversial; it has been seen in strain CDC 1551 but not in H37Rv.
Interaction partners:
- Putative quercetin 2,3-dioxygenase Rv0181c
- ECF RNA polymerase sigma factor SigL
- ECF RNA polymerase sigma factor SigD
- RNA polymerase sigma factor SigB
- ECF RNA polymerase sigma factor SigM
- Probable conserved transmembrane protein
- RNA polymerase sigma factor SigF
- ECF RNA polymerase sigma factor SigK
Sequence:
MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAENSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFAGKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPDVTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVHLPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL
Protein: Toll-like receptor 3 (CD antigen CD283) (Q99MB1)
Organism: Mus musculus (Mouse)
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane {ECO:0000250|UniProtKB:O15455}. Early endosome {ECO:0000250|UniProtKB:O15455}.
Interaction partners:
- TNF receptor-associated factor 6
- TIR domain-containing adapter molecule 1
- Protein unc-93 homolog B1
- TIR domain-containing adapter molecule 2
- Receptor-interacting serine/threonine-protein kinase 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Myeloid differentiation primary response protein MyD88
- Mitogen-activated protein kinase kinase kinase 7
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Glycogen synthase kinase-3 beta
Sequence:
MKGCSSYLMYSFGGLLSLWILLVSSTNQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSSCKDSAPFELLFIISTSMLLVFILVVLLIHIEGWRISFYWNVSVHRILGFKEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKSHCILNWPVQKERINAFHHKLQVALGSRNSAH
Protein: Larval cuticle protein 3 (Larval cuticle protein III) (P07188)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the larval cuticle.
Interaction partners:
- Larval cuticle protein 2
- Larval cuticle protein 4
- FI01403p
- Peptidase S1 domain-containing protein
- Larval cuticle protein 9
Sequence:
MFKILLVCSLAALVAANANVEVKELVNDVQPDGFVSKLVLDDGSASSATGDIHGNIDGVFEWISPEGVHVRVSYKADENGYQPQSDLLPTPPPIPAAILKAIAYIEANPSKN
Protein: Fe2OG dioxygenase domain-containing protein (Q57WX8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRTFSLFTTLVRLGRGPENVTEEASNSLLEALQKHGYCYVQHPFIQWEILDQVHRDSRIFFERYLLDLPEEKQRTRKEKFSKKLIAPRKPIRAMTPYELESIKTSSGFRGYYRYIGAGGVDDAIECFSVGREVQSPVELREPYYRLSGWQRDEYLPLISRRNAWDSLLTHPKDGSGDPNGVHAFMADYREMILAYYDLCSEVALDVLRHISCGLGVRPSIPQGGPDPDSGYDLEYFTQFHNKLDFDLQAKYYPRFGQGARTRGGVEVKGVQSASNPKGVKVLRRKTARGQPLVNEDEENAVLRLDSHKDLSTVTLLAQDALGGLEVWDNESEQFNPVPVLNDALLVNAGLFLEKWTGGLLEATPHRVRNVRGGSSRCSVVFFCLPNHDARIEPLLQRDENPSLDAEEGFYAGDLMPAAP
Protein: Sodium/potassium-transporting ATPase subunit alpha (C0H8U1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGLGKGKDDYKLAATSEDDGNKKSKKELKKAKEKKDMDDLKKEVDLDDHKLTLDELHRKYGTDLARGLSSARAKEILLRDGPNTLTPPPTTPEWVKFCRQLFGGFSMLLWIGAMLCFLAYGIQAASEDEPANDNLYLGVVLSVVVIVTGCFSYYQEAKSSKIMDSFKNLVPQQALVVRDGEKKNINAEEVVVGDLVEVKGGDRIPADLRIVSASGCKVDNSSLTGESEPQTRTPDFSNDNPLETRNIAFFSTNCVEGTARGIVINTGDHTVMGRIATLATSLEGGKTPIAKEIEHFIHIITGVAVFLGVSFFVLSLILGYGWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTCFDKSSATWASLARVAGLCNRAVFLAEQNNVPILKRDVAGDASESALLKCIELCCGSVKAMREKYSKIAEIPFNSTNKYQLSIHKNIAAGESKHLLVMKGAPERILDRCSTILIHGKEQPLDDELKEAFQNAYEELGGLGERVLGFCHFQLPDDQFAECFNFDCEEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLKIPVSEVNPRDAKACVVHGGELKDLSAEQLDDILSHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEEAENDIMKRQPRNPKTDKLVNERLISIAYGQIGMMQATAGFFTYFVILAENGFLPMDLLGMRVDWDNKIMNDMEDSYGQQWTYERRKIVEFTCHTAFFASIVVVQWADLIICKTRRNSILQQGMKNRILIFGLFEETALAVFLSYCPGMDVALRMYPLKPCWWFCALPYSLLIFLYDEGRRYILRRNPGGWVEQETYY
Protein: ATP-dependent DEAD/H RNA helicase, putative (EC 3.6.1.-) (Q385S0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein NSA1
- Ribosome production factor 2 homolog
- CCAAT-binding factor domain-containing protein
- Peter pan protein, putative
- RNA-binding protein, putative
- ATP-dependent RNA helicase
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar RNA binding protein, putative
- Pescadillo homolog
- rRNA processing protein, putative
Sequence:
MSGSPSDVVRKAWSDIALDSRLVEAIKKLKWKAPTPVQSACIPLAMKGRDLAIQSQTGTGKTGAFLIPVIQRIITENERACGRRNAQNPVALILLPSEELCKQTVEVANALTRYVKPRIIVNDLTSRVSTANALRLTAAPILVSTAASLGKLCRNGSVTSDDMKPLRCVVIDEADLIMSIAEGSLRAVQSVLPTSAQTILASATLTDGVAQIKGQLLHNPITVSLKPDDGEKEPTGCEGPVGAEDVVLESRVTVRGGAAAAGTLRHYYLVSTDECHHHTLLYALYRLGHIKGKTLVFVNSEDTTYKLHNFLAQLGINALVYDSNLPMNVRVDALRRFQTGKVGTLVCTDGTLESLDRMRGATDGDEETTTSTPRSNSRGKRKSLAAGGDEGGSALHRGIDFSDVSNVILFDGVTNATTSDFSRYTHRVGRAGRGNKDGVAITFLTLHQARKVKQQLRDYLGGTFQSFAPFKQLDRHAASRLQYRVDNVLASITRSSTRRQRVAAVAAELTRSAHLMSHMGDKDSGVLKRILSRSKGDTKCDQTVVDVPEYMRIKGADSAESYRRRVRAPKKHTTAVAKRSAQKRSRDPLGSLTSSLKRRKL
Protein: Glutathione S-transferase (EC 2.5.1.18) (Q9ZP61)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU369102}.
Interaction partners:
Sequence:
MAAAAEVVLLDFWVSPFGQRCRIALAEKGVAYEYREQDLLDKGELLLRSNPIHKKIPVLLHAGRPVCESLVILQYIDEAWPDVAPLLPKDDPYARAQARFWADYIDKKIYDSQTRLWKFEGEAREQAKKDLVEVLETLEGELADKPFFGGGALGFVDVALVPFTSWFLAYEKLGGFSVQEHCPRIVAWAARCRERESVAKAMSDPAKVLEFVQFLQSKFGAK
Protein: CASP-like protein PIMP1 (CASP-like protein 4D1) (CaCASPL4D1) (Pathogen-induced membrane protein 1) (CaPIMP1) (A1XGB4)
Organism: Capsicum annuum (Capsicum pepper)
Function: Required for defense response to Xanthomonas campestris pv. vesicatoria (Xcv). In heterologous systems, confers resistance to bacterial pathogens such as Pseudomonas syringae pv. tomato but susceptibility to pathogenic oomycetes such as Hylaloperonospora parasitica when expressed in Arabidopsis thaliana. May be involved in the regulation of responses to bitoic and abiotic stresses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18506481}; Multi-pass membrane protein {ECO:0000269|PubMed:18506481}.
Interaction partners:
Sequence:
MTPPPTSTVPPYVSLIVRILTLICLLISFIVIATNNQTVSTVAGDVKIKFKDFYAYRYLIATVIIGMAYTLLQIAFSISLLTTGNRIGGEGFLLFDFYGDKFISYFLVTGAAASFGMTQDLKQLEGSDNYSKFLNTSNAAASLCLIGFFFAVASSIFSSYNLPKRI
Protein: GDSL esterase/lipase (T28P6.3 protein) (Q9SXB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GDSL esterase/lipase LTL1
- GDSL esterase/lipase 1
- GDSL esterase/lipase APG
Sequence:
MDPIASVLEKVKSFTKSSQDLVSRHFGFHENPSRLNPIDILKRLQRETFSDLMKLRERQEKVERIISSQKLSKGGPFQETSTHVRGEVDVLGAILLMGNTDEESFNGLNKEGVRPGLLSRFVFETSLRETDRLVAELVAGYNGAGSHRDFLGGELSLAKVFYKADINDWFSAIAIPVGAHFRDIEASTVSSYQGMSLTEVSELGPPLLSQHNGSAIGLTFRKSNITASLAQSMSNVEVEQGLTAPNRCFRTFGQVTCHILRSLKLSLLGCHQVLTSSSNLHSVGAITVPVSFLRRHTATEPEPSAPPLEMSRNMNHVSSSSIALKLDSLMDESTKLGGWIEIQNSREKQVKWSVSITDNPEDEVGWGMSVGGVVDGSRNHDQFQVESYLKFNIGDRFRLSPCLVYHTNSDGRTIGLMLKSHWSL
Protein: Myogenic factor 6 (Myf-6) (Muscle-specific regulatory factor 4) (P19335)
Organism: Rattus norvegicus (Rat)
Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. May play a role in controlling terminal differentiation events.
Subcellular location: Nucleus.
Interaction partners:
- Myoblast determination protein 1
- Myogenic factor
- Paired box 7
- Myosin-4
- Myocyte-specific enhancer factor 2D
- Growth/differentiation factor 8
- Paired box 3
- Myocyte-specific enhancer factor 2A
- Myogenin
- Transcription factor E2-alpha
Sequence:
MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAINYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFLRTCSPQWPSVSDHSRGLVITAKEGGASVDASASSSLQRLSSIVDSISSEERKLPSVEEVVEK
Protein: Bcl-2-like protein 11 (Bcl2-L-11) (Bcl-2-related ovarian death protein) (Bcl2-interacting mediator of cell death) (O88498)
Organism: Rattus norvegicus (Rat)
Function: Induces apoptosis and anoikis.
Subcellular location: Membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.
Interaction partners:
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 2
- Apoptosis regulator BAX
- Bcl-2-like protein 1
- Phorbol-12-myristate-13-acetate-induced protein 1
- BCL2-antagonist/killer 1, isoform CRA_b.
- BH3-interacting domain death agonist
- Bcl-2-related protein A1
- Beclin-1
Sequence:
MAKQPSDVNSECDREGGQLQPAERPPQLRPGAPTSLQTESQGNPDGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNETYTRRAFANDYREAEDHPQMVILQLLRFIFRLVWRRH
Protein: 3-isopropylmalate dehydrogenase (3-IPM-DH) (IMDH) (EC 1.1.1.85) (Beta-IPM dehydrogenase) (P04173)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
Subcellular location: Cytoplasm.
Interaction partners:
- 3-isopropylmalate dehydratase
- Acetolactate synthase catalytic subunit, mitochondrial
- Acetolactate synthase small subunit, mitochondrial
- Orotidine 5'-phosphate decarboxylase
- Phosphoribosylaminoimidazole carboxylase
- Imidazoleglycerol-phosphate dehydratase
- Homoaconitase, mitochondrial
- L-2-aminoadipate reductase
- N-
- 2-isopropylmalate synthase
Sequence:
MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKILA
Protein: Uncharacterized protein (Q9KP76)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Lipopolysaccharide export system permease protein LptF
- Lipopolysaccharide export system ATP-binding protein LptB
- Lipopolysaccharide export system protein LptC
- LPS-assembly protein LptD
Sequence:
MFKILDWYIGRTIVATTALVLVTFVGLSGIIKYVEQLRKVGEGSYDLLQALLFVVLSIPRDVEMFFPMAALLGALIGLGALASSSELVVMQAAGFSKLDIGLSVLKTAIPLMIIVTLLGEWGAPQAQKMARDMRAFATSGGAIMSVRTGVWARDANDFIFIAKVENEHLYGLNLWRFDENKKLSTVIFSEQVDYVANNEWLMKDAVLTRLVNDIEISKESLPEYRWRTSLAPDKLAVVTVKPEELSLTGLSDYVHYLKASEQDSSRYELALWRKVTQPISIAVMMLMALSFIFGPLRSVTMGARILSGVIAGFSFYISSEFFGPLSLVYGLPPLFGALAPSLVFLAIALGLLGRKL
Protein: Eomesodermin (E8Z504)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MQLENILPSASTNLPNTFYNLSSSDSANNSPGPSQIEYQEVDRTESEPSIGPNKYLSGVGNAMMGEGEGNAFTGTKAAPDGRKDSPVLGEDDQSTGRRYHIDELGSDRYFISSSQTSSDVANQCSLFPYAGQTGTMYSGSNGSRYSSLHYGSVLPPAGFSSSVCPSRSQFGSSYQFGQGPGCLYPSYPGTGSGIGSMALPGSTPGTRAQVYLCNRPLWLKFHRFQTEMIITKQGRRMFPFLSFNITGLNLAAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEEGVEDIGSDAKTQTFTFPENQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTAPEGDRLTPSPTASPRSHQIVPGARYAMQPFFQDQFVNNLPQNRFYTGERAVPQTNSLLSPQAEDAGASSAQRWFVTPVQQSGSNKLDLSYDQDYSASSLLSYGIKPLPLQTSHALSYYPDSAFASMAAGWGTRSTYQRKMTTGLPWSPRPSPPAFADDQLAASKDKLPEESTAASTWVETSHSLKSVDSTDSGVYSMVCKRRRMSPGGSSTENSPTIKCENLTTTEEYNKDNPKGMGYYAFYASP
Protein: LD20987p (TNF-receptor-associated factor 1) (TNF-receptor-associated factor 4, isoform A) (Q9XYR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Apoptotic signal-regulating kinase 1, isoform C
- LD20892p
- Mitogen-activated protein kinase kinase kinase 7
- LD40663p
- Tumor necrosis factor receptor superfamily member wgn
- Female-specific protein transformer
- Dual specificity mitogen-activated protein kinase kinase hemipterous
- Transformer-2 sex-determining protein
- Death-associated inhibitor of apoptosis 1
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
Sequence:
MVRSLAQWTKTLSFPSRLSPNRNSKDCSTLASPVPPPTPPRNKTTSGSGNCATSRSSSSTVSSSHSSSHSSPTPGNNNNNMPITELEQIIYPGPDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHLNACKHDATQCPNKCGAQIPRIMMTDHLQYTCTMRRTRCEFCQSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCRFKGPRQMLEAHLESNAAAHLSLMVALSSRQGQQIQMLKSAVSKLSINYTGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHSRPFIKGDTVFLRVKVDPSKIVAV
Protein: Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) (O60664)
Organism: Homo sapiens (Human)
Function: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:15545278, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:37443287}. Endosome membrane {ECO:0000269|PubMed:15545278}; Peripheral membrane protein {ECO:0000269|PubMed:15545278}; Cytoplasmic side {ECO:0000269|PubMed:15545278}. Cytoplasm {ECO:0000269|PubMed:15545278, ECO:0000269|PubMed:26357594, ECO:0000269|PubMed:9590177}. Note=Membrane associated on endosomes (PubMed:15545278). Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278). {ECO:0000269|PubMed:15545278}.
Interaction partners:
- Cation-independent mannose-6-phosphate receptor
- Rho-related BTB domain-containing protein 3
- Heat shock cognate 71 kDa protein
- Cation-dependent mannose-6-phosphate receptor
- Ras-related protein Rab-9A
- Vesicle-associated membrane protein 3
- Patatin-like phospholipase domain-containing protein 2
- Rab9 effector protein with kelch motifs
- 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
- Ras-related protein Rab-5A
Sequence:
MSADGAEADGSTQVTVEEPVQQPSVVDRVASMPLISSTCDMVSAAYASTKESYPHIKTVCDAAEKGVRTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDKLEENLPILQQPTEKVLADTKELVSSKVSGAQEMVSSAKDTVATQLSEAVDATRGAVQSGVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSEEWADNHLPLTDAELARIATSLDGFDVASVQQQRQEQSYFVRLGSLSERLRQHAYEHSLGKLRATKQRAQEALLQLSQVLSLMETVKQGVDQKLVEGQEKLHQMWLSWNQKQLQGPEKEPPKPEQVESRALTMFRDIAQQLQATCTSLGSSIQGLPTNVKDQVQQARRQVEDLQATFSSIHSFQDLSSSILAQSRERVASAREALDHMVEYVAQNTPVTWLVGPFAPGITEKAPEEKK
Protein: 40S ribosomal protein S9, putative (Q57VP3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S15a, putative
- 60S ribosomal protein L2, putative
- Large ribosomal subunit protein uL5
- Ribosomal protein
- 60S ribosomal protein L18a
- 60S ribosomal protein L27, putative
- 60S ribosomal protein L7a
- Elongation factor 2
- 60S ribosomal protein L4
- Ribosomal protein S19, putative
Sequence:
MRNYNNFNRVWKAPRRPFEKERLDREMKLCGQYGLRCKREIWRVNMTLSKMRRTARLLLTLPENHPRRLLEGSAIMRRCHGYGFLDEDKDKLDYVLSLTVPDILERRLQTVVFKHGLAKSVHHSRVLIQQRHIAVAKQIVTIPSFIVRVSSEHHIAFADASPFGNGRPGRVKRVKRNAAKKGSGGGDDDE
Protein: Probable anion transporter 5 (Phosphate transporter PHT4;6) (Q9FKV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inorganic phosphate and probable anion transporter.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18086223}; Multi-pass membrane protein {ECO:0000269|PubMed:18086223}.
Interaction partners:
- Inorganic phosphate transporter 1-4
- Probable inorganic phosphate transporter 1-5
- Inorganic phosphate transporter 2-1, chloroplastic
- Probable inorganic phosphate transporter 1-3
- Inorganic phosphate transporter 1-1
- Alpha/beta-Hydrolases superfamily protein
- F-box/FBD/LRR-repeat protein At1g13570
- Defensin-like protein 268
- Putative defensin-like protein 288
- ATG8-interacting protein 2
Sequence:
MKLSNIPQRYVIVFLTFLSTCVCYIERVGFSIAYTVAADAAGINQSSKGTILSTFFVGYACSQVPGGWAAQKIGGRKVLLLSFVLWSSTCFLVPLDPNRVGLLVVARLLVGVAQGFIFPSIHTVLAQWVPPHERSRLVSITTSGMYLGAALGMWLLPALVELRGPESVFLAEALAGVIWSLLWIRYATDPPRSEHPKAAAAGFGGALLPTNVNHHKVTHIPWKKIMLSLPVWAIVVNNFTFHYALYVLMNWLPTYFELGLQISLQGMDSSKMVPYLNMFVFSIVGGFIADYLITKRILSVTRTRKFLNTVGFLIASAALMVLPMFRTENGVILCSSVALGFLALGRAGFAVNHMDIAPRYAGIVMGVSNTAGTLAGIIGVDLTGKLLEASKLVYSDLSHPESWRVVFFIPGLLCIFSSVVFLLFSTGERIFD
Protein: Protein disulfide-isomerase (EC 5.3.4.1) (V9HVY3)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}. Melanosome {ECO:0000256|ARBA:ARBA00004223}.
Interaction partners:
Sequence:
MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
Protein: Uncharacterized protein (Q387X0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKKNNSKGNSSANKASAGDVSQVQFWNYLKKGDDEGLEKTLLQRVENSETGEVTVVVNSAVANQLVNSPNAKKILPLSYAISQGMSERGLHALLLAGAKIDAMDGTSERATALHAACWGENDSAVMLLLRCGANPLAVDSQGRTPLHVLASLNAISLFSLVLETVTKFGVDQNTCRGDDTEQRLEGHLSLEGHSPVIVPAERLLDSRDKAGLTVLHTAVSDISSGSDGVISKLLSYLEEMAKTSADKVSRLVNMTTDSESTALHLILSWPNCDEGVMMHTVERLLKLGASASAVDKYGQTAVTVAVTTHVGITVANVVRSLLRSVEEGEDNEARLKNVFMQCDNEKGYALIHHAVAANNIEVVKVLVNFLGEFDGASGSQYIRHWLGGLLTDNNETVVQLIVEYGCDEIADLLIGFQAINKIDYEKYKEEHEKIREDESVGNLEDGDIDSNEEGGHEIGDEVGLRGRQFAGRSTAAGASSGGSRIQLARRARARAQAQSAAQRKKDSPRQDSEVADRQRNAAPLWVMLCAVLIFIASAALVGFTFRNTIVSLFG
Protein: Aquaglycerol porin AQY3 (Aquaporin-3) (P43549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Channel protein that mediates glycerol entry under ethanol stimulation. Does not seem to mediate glycerol uptake under standard conditions.
Subcellular location: Cell membrane {ECO:0000305|PubMed:12832087}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Exosome complex component RRP43
- Glycerol uptake/efflux facilitator protein
- cAMP-dependent protein kinase regulatory subunit
- Glycerol kinase
- Uncharacterized protein YMR130W
- Nucleoside diphosphate kinase
- AP-1 complex subunit mu-1-I
- Adaptin medium chain homolog APM2
Sequence:
MSYESGRSSSSSESTRPPTLKEEPNGKIAWEESVKKSRENNENDSTLLRRKLGETRKAIETGGSSRNKLSALTPLKKVVDERKDSVQPQVPSMGFTYSLPNLKTLNSFSDAEQARIMQDYLSRGVNQGNSNNYVDPLYRQLNPTMGSSRNRPVWSLNQPLPHVLDRGLAAKMIQKNMDARSRASSRRGSTDISRGGSTTSVKDWKRLLRGAAPGKKLGDIEAQTQRDNTVGADVKPTKLEPENPQKPSNTHIENVSRKKKRTSHNVNFSLGDESYASSIADAESRKLKNMQTLDGSTPVYTKLPEELIEEENKSTSALDGNEIGASEDEDADIMTFPNFWAKIRYHMREPFAEFLGTLVLVIFGVGGNLQATVTKGSGGSYESLSFAWGFGCMLGVYVAGGISGGHINPAVTISMAIFRKFPWKKVPVYIVAQIIGAYFGGAMAYGYFWSSITEFEGGPHIRTTATGACLFTDPKSYVTWRNAFFDEFIGASILVGCLMALLDDSNAPPGNGMTALIIGFLVAAIGMALGYQTSFTINPARDLGPRIFASMIGYGPHAFHLTHWWWTWGAWGGPIAGGIAGALIYDIFIFTGCESPVNYPDNGYIENRVGKLLHAEFHQNDGTVSDESGVNSNSNTGSKKSVPTSS
Protein: Glutathione S-transferase (G5EC71)
Organism: Caenorhabditis elegans
Interaction partners:
- Glutathione S-transferase omega
- Glutathione synthetase
- Glutathione reductase, mitochondrial
- Glutathione S-transferase P
- Glutathione peroxidase 3
- Glutathione peroxidase
- glutathione transferase
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase
- Glutathione S-transferase P 10
- Glutathione peroxidase 1
Sequence:
MAEYKFYYFNGRGLGDVSRQLFALSGTKYEDIRIEHADWPAQKPKMPFGQMPVLELSSGLQIPQSMAIARYLAKKFGYAGKTDEEAALADALIDQFKDFYAEIKPYYYAKIGVLQNDTEEEKKKTLIPARDKFLTIIGKFLKLSISGFLFSGGLTYADLMICDNMRTLIAWWPEYLNEYPDIKAWYQKVDGIPEIRKHLESSPDKGF
Protein: Serine/arginine-rich SC35-like splicing factor SCL28 (At-SCL28) (AtSCL28) (28 kDa SC35-like splicing factor) (SC35-like splicing factor 28) (Serine/arginine-rich splicing factor 28) (Q1PDV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in intron recognition and spliceosome assembly (Probable). Probably active at the 5' splice sites.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:15133128}.
Interaction partners:
- Serine/arginine-rich splicing factor RS2Z33
- Serine/arginine-rich-splicing factor SR34
- Serine/arginine-rich splicing factor RSZ21
- Serine/arginine-rich splicing factor SR30
- Serine/arginine-rich splicing factor SC35
- Serine/arginine-rich SC35-like splicing factor SCL30
- Serine/arginine-rich SC35-like splicing factor SCL30A
- Serine/arginine-rich SC35-like splicing factor SCL33
- Serine/arginine-rich splicing factor SR34B
- Serine/arginine-rich splicing factor RSZ22
Sequence:
MARARSRSRSYSPRPRDRSPPRERKGYDDNRLRERPSSRDHESSGPSGLLIRNLPLDARPNDLRDSFERFGPLKDIYLPRNYYTGEPRGFGFVKYRYAEDAAEAMKRMNHKVIGGREIAIVFAEENRKTPQEMRTTNGTSGRHGDYKRTSHRSPRRRYRSHSRSRSPPRRESRHSKVREDDLYSPRRRSRSISRSPLPRNEREYKSRNCRSPREERVLTPIRSRCLSRSRSRSLSR
Protein: tRNA carboxymethyluridine synthase (EC 2.3.1.311) (Q57YY2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLKRPRDEGGHDDLNTGREENAQRNFDSMEEQDQHTPHLSLREARFSGRSMQEGFHLQLGEYEEPDEAKEVEELMNGHEDFGDLPKERQKALLDAVRVLVRKAAGITNKNQLEHLRVKASRLVGFKDTARKSELTAAYRQLVRAGEVQESAAVEELLLRKRGKSHSGVLVVTVFMGPGQFSCPKDCHYCPNQPGIARSYLLKEPGVLRGYRNGWDPIRQFYDRASALENNGHVVDKIELIILGGTFSFYPKKYVEEFITGNFYAANTYYDSTPLRPIGTLEQEITANEDARCRIIGVTIETRPDYINLSELRRFRSLGVTRVQVGIQHLDDDILTIVNRDCPTSKTIVAIKRLLDAGFKVDAHWMPDLPGSSYSKDHEMFEYLFSEDNENFQVDQWKVYPTATVPYTKIEDWYRTGKYKPYAELDGGSWMVKLLVYIMENCPRRIRLNRIIRDIPTTYIMGGERRCNLRQVIEAEMKAKGIRCKDIRERECKGAPVDRNQTKVFVNEFRASGGTEFYLSVENMEQTILYGHLRLRLRDDSGESNSLVKALEGCALIRELHTYGKLIAVSRPNSGNEAQHMGVGTQLMREAERIAIERGFMKIAVIAGVGVRRYYAKLGYKLEDTYMVKQLTADKGSTITEEQVEQDDDNDNGGFISMLKGFMFGK