wanglab/gogpt-training-data huggingface dataset:
Protein: Possible flavoprotein (Q50616)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Succinate dehydrogenase 2 membrane subunit SdhC
- Conserved protein
- 3-oxosteroid 1-dehydrogenase
- Multifunctional 2-oxoglutarate metabolism enzyme
- Probable succinate dehydrogenase [iron-sulfur subunit]
- Fumarate reductase iron-sulfur subunit
- succinate dehydrogenase
- Iron-dependent extradiol dioxygenase
- Probable succinate dehydrogenase SdhD
- Conserved protein
Sequence:
MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLERAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYLVAVSREPDHDKIRAYCDGSVEHFNWLEGLGFQFERSYFPGKAVIQPNTEGLMFTGNEKVWPFLELAVPAPRGHKVPVPGDTGGAAMVIDLLLKRAASLGIQIRYETGATELIVDGTGKVTGVMWKRFSETGAIKAKSVIIAAGGFVMNPDMVAKYTPKLAEKPFVLGNTYDDGLGIRLGVSAGGATQHMDQMFITAPPYPPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVDEAHLEHPKMPLVPLIDGWETVVEMEAALGIPPGNLAATLDRYNAYAARGADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYAGFTLGGLATSVDGQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEGSFFGRRAGAHAAARAQGM
Protein: Transcription factor MYB4 (Myb-related protein 4) (OsMyb4) (Transcription factor RLTR1) (Q7XBH4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional activator involved in cold stress response. Regulates positively the expression of genes involved in reactive oxygen species (ROS) scavenging such as peroxidase and superoxide dismutase during cold stress. Transactivates a complex gene network that have major effects on stress tolerance and panicle development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
Sequence:
MGRAPCCEKMGLKKGPWTPEEDKVLVAHIQRHGHGNWRALPKQAGLLRCGKSCRLRWINYLRPDIKRGNFSKEEEDTIIHLHELLGNRWSAIAARLPGRTDNEIKNVWHTHLKKRLDAPAQGGHVAASGGKKHKKPKSAKKPAAAAAAPPASPERSASSSVTESSMASSVAEEHGNAGISSASASVCAKEESSFTSASEEFQIDDSFWSETLSMPLDGYDVSMEPGDAFVAPPSADDMDYWLGVFMESGEAQDLPQI
Protein: DENN domain-containing protein 4B (O75064)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:20937701}.
Interaction partners:
Sequence:
MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEEVPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQVLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYCRLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC
Protein: C-1-tetrahydrofolate synthase, cytoplasmic, putative (EC 1.5.1.5) (Q57WP0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenylosuccinate lyase
- Glycine cleavage system P protein
- Aminomethyltransferase
- Adenylosuccinate synthetase
- Methionyl-trna formyltransferase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Folate transporter, putative
- Folate transporter, putative
- Glycine cleavage system H protein
Sequence:
MPEAVVIDGRAVAKAIQKELTEEVALLERRYKGRRPGLSTIICGKRKDSQTYVRLKRKAAAACGFRNFSVELPANVTQETLEREVIRLNEEEACHSIVVQLPLPPHIDKVAALSKIKPEKDADCLLPVNVGQLHIRERNPAIVPCTASAVMELLRCSGVEICGKRVVVLGRGDIAGLPVATLLANEDATVTVVHSATPLCDIADIVRASDIVVSAAGQPGLVRGEWIKLGAAVIDVGTTPVADPSKVPGYRLVGDVCFDVARKRAAYITPVPGGVGPVTVSMLLKNTLTMFKRSVRAL
Protein: 1-deoxypentalenic acid 11-beta-hydroxylase (EC 1.14.11.35) (Neopentalenolactone biosynthesis protein H) (Q82IZ1)
Organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function: Catalyzes the conversion of 1-deoxypentalenic acid to 11-beta-hydroxy-1-deoxypentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
Interaction partners:
Sequence:
MTNVTGDYTDCTPLLGDRAALDSFYEEHGYLFLRNVLDRDLVKTVAEQMREGLVALGAADPHATLEELTIDSFESVDEVAMHDYVKYDAFWNNPSTIKVFEQVFGEPVFVFLSTTIRYYPSQAGSEEPSFHYLTPFHQDGFYIGPNQDFRTFWIPLIRTTRESGGVALADGSHRRGKRDHVLNESFRRFGHPVRGIPPTEVSEDEHLLHSPMEPGDILLFHAHMCHKSIPNLSKDPRLMRMSMDTRVQPAKSHRGFNAMTPWTESAKDASKGIMAKITGTPTDVE
Protein: Trypsin beta (EC 3.4.21.4) (P35004)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Jonah 65Aiv
- Trypsin alpha
- Trypsin epsilon
- trypsin
- GH01508p
- Bazooka, isoform B
- Uncharacterized protein
- Peptidase S1 domain-containing protein
- Jonah 44E, isoform A
- Jonah 74E
Sequence:
MLKFLILLSAVACALGGTIPEGLLPQLDGRIVGGTATTISSFPWQISLQRSGSHSCGGSIYSARVIVTAAHCLQSVSASSLQIRAGSSYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVLHLSSSLSFSSTIKAIGLASSNPANGAAASVSGWGTESSGSSSIPSQLRYVNVNIVSQSRCSSSSYGYGNQIKSSMICAFASGKDSCQGDSGGPLVSGGVLVGVVSWGYGCAAANYPGVYADVAALRSWVINNA
Protein: Peroxisomal testis-specific protein 1 (Small testis-specific peroxisomal protein) (Q8NFP0)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome {ECO:0000250}.
Interaction partners:
Sequence:
MKKKHDGIVYETKEVLNPSPKVTHCCKSLWLKYSFQKAYMTQLVSSQPVPAMSRNPDHNLLSQPKEHSIVQKHHQEEIIHKLAMQLRHIGDNIDHRMVREDLQQDGRDALDHFVFFFFRRVQVLLHFFWNNHLL
Protein: Insulin receptor substrate 2 (IRS-2) (4PS) (P81122)
Organism: Mus musculus (Mouse)
Function: May mediate the control of various cellular processes by insulin.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17636024, ECO:0000269|PubMed:25830382}.
Interaction partners:
- Growth factor receptor-bound protein 2
- Insulin receptor substrate 1
- Insulin-like growth factor 1 receptor
- Insulin-1
- Insulin-2
- Insulin receptor
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Tyrosine-protein kinase JAK2
- Suppressor of cytokine signaling 3
- Suppressor of cytokine signaling 1
Sequence:
MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEASAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYKASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALRGGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSLQQPLPPAPGDLYRLPPASAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPPKPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAVPPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQPGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVKE
Protein: Lymphocyte antigen 6C1 (Ly-6C1) (P0CW02)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MDTSHTTKSCVLILLVALLCAERAQGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGVPIRDPNIRERTSCCSEDLCNAAVPTAGSTWTMAGVLLFSLSSVVLQTLL
Protein: Photoactivated adenylate cyclase subunit beta (EC 4.6.1.1) (Photoactivated adenylyl cyclase subunit beta) (Q8S9F1)
Organism: Euglena gracilis
Function: Acts as a blue light photoreceptor for the step-up photophobic response. Mediates photoavoidance.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:11875575, ECO:0000269|PubMed:16121285}. Note=Paraflagellar body, flagellum and paraxonemal bodies (PABs).
Interaction partners:
Sequence:
MYILVWKKGQQIKTFHTLDEAAQFKAASNIDEAQMFSVTVAPAISASGGSNEATNLRRLMYLSKSTNPEECNPQFLAEMARVATIRNREIGVSGFLMYSSPFFFQVIEGTDEDLDFLFAKISADPRHERCIVLANGPCTGRMYGDWHMKDSHMDSITTHPAMKTILYQIARSFSSMWSYLPKSAGNMLLLGKDPAAQPPEPMSVVVTFIYLVEFGSILSNPNLTEQAAEVLSTFVDVCVKNVEGSGGNIAKFITGICMAYWPINRTEEALTAIQQISEDLAQLRSQQAPGSAVSLMYSQAGVHYGRAMLCNAGSRKSDFTLLGDCINTTSRIATLAKKLKTPLLFSFEVRCLLGDEMREEIEGAGMHQVKGRDKPVVVYQFPGPELDVEMVRQKIEQFTPGRFRCQMPVVEYEALPISQRPPIFDDTPKGNPRPRTPGYGGRQRSDSLVDRLIMIAKLAGPSVSATGDTTLTTLTYISQATRPMSRLDLSAIMRTATRRNAQQSITGTLLHVNGLFVQTLEGPKDAVVNLYLRIRQDPRHTDVTTVHMAPLQERVYPSEWTLTSATEEMLATFPPLQDVLSQLAKSFTSLETYVPSTVVRYLTAGNNPRNLMPVSCGVVMLATDICSFTSLTEKSSLTEVWMICNTFIDACTSAICQEGGEVIKLIGDCVTAYFPGNNADSAVAAAQELFTFCRQLREAFVDVLDVRGCVSCGVGLDYGQVVMAQCGSLGLTEYVVAGAVSARVMEVEAITREVGYAIVVTEPVADRLSPQLRDHGIVPTPQAIEGLPCYGIAGEEFELDVDSIKRGIKALHAARSGEKPLTEPEEAKPDFRVSPGRVRHGDSGRRSNSAQGKRSIQVR
Protein: CSF3 (Colony stimulating factor 3 (Granulocyte) b precursor) (B5L332)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKTCCLLLLHLCVCQLLCVPLQPQLTHTHTEHTLRALSLAKKILNDIPAVQELCAPNTGLSSSTEEFLSSEFQIPTLPLLKSEDLTLEERVQRMLIGLELHHRVLLKLLEPCRPENLLNDLAELRTLLLLQVPSAGPQVLPHTHTLSAPLSQFKLQVRVRATLRQLRSFMQDVFRSLRCISVSQC
Protein: ARF6 guanine nucleotide exchange factor IQArfGEF (IQ motif and Sec7 domain 2) (A4GZ26)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
Protein: Cytokine receptor family member b14 (Interferon lambda receptor 1 precursor) (D9IL84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MWPLGTAMFLLCCVGCWCQNCNLTKPYFKSQNFFSVLHWDPVDLPGQTALYSVQYSPYGSPRQLVPWCQNISSPVCDLTDVMSAVVTEVTITYKAIVYAGAQCLGEVRFSPFKETTLAAPQLTVTSNQTHLNVTLSKPRVPWNRSIESIKYWADYRDVKRYPVKYIVRLTHPGSQEYFSRTSPSVLIELLWKDVEYCGEVFYSLTHPGWFRPSENTTFCLTISAPNPLLHILMWPSVLAALLMVFLSVMLCHRFVKRKRSLPKALMLPENNTPPFWSDPKDNISKVEMWSGMFFGMKPDPQTPSLTPQKSEITVKDNAYASQEPYRCQQDGPIQNSREPSENYSLCLPAQMPKESFNSSDSFSPESESPKMIHSDTSESLNNSDTFTPKSDSVKLIQSDANESFNNSESLSSDSDLVELIHLDTNESFSSSDSFIPVTDSVEFIHSDAECKTLVVPARPDKNGALQFHELFFQDESFPDESAERMPLLTDLIQSDSSYLPEQVPNVVTSNYRQNWVPGLLLEGQEDKRTYIMRTEKTEDSPEAEEDFRESEESRIGVVFLDRCLLEIQGLSLS
Protein: Protein SEY1 (J9VP90)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03109}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03109}. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules. {ECO:0000256|HAMAP-Rule:MF_03109}.
Interaction partners:
Sequence:
MNQTPQIAQDLLKNPPQELQQLLNDPRTPDRARKAVQELQVPSVGSGAAGKESSRLQIVNENQEFTKELSPYLAKWDLLDKGFAYDVVAVFGSQSTGKSTLLNRLFGTTFDVMDESKRQQTTRGIWMCPSQYSNTLVMDVEGTDGRERGEDQDFERKSALFSLASTEVLIVNLWEHQIGLYNGANMGLLKTVFEVNLGLFGGGGDNSKPKPQEKTLILFVIRDHVGATPMSNLTATLTQDMERIWDSLSKPAHLEDAALSSYFDLSFAALPHKVLMPEKFEEAVLELRQRFTDRSREDYVFQPAYHKRIPADGVSFYMEGIWQQVLTNKDLDLPTQQELLAQFRCDEISTVVFEAFLASAKIVRRPVEAGSVVEGLGALMRDWLETALGKFDRDASRYHSAVYQRKRLDLVASLHASLSPLFLGQLKNLHKIETAKFSRDIVAGVKEPGYDFGIIVEEGKKGARERFMAGAKEVRVEDTDWEYEHELALLDDDLKLIADKCRADETKKMVNAIERNVKRQILEPVEVAMSQPTKTMWDTVLKTYSEVIGAAEETYLSKAKSYNCSDEENSVALTSLRARAWLALRRKLEEQTSDSTILTTLRTKFEDNFRYDEVGVPRVWKPEDDIEAAFRKAKDETLDLLPLFANIAPTDDSLLPELPPPEPSFDLESDPSPFDPSTAFTLLTATKLLSLESRFKRDVDAAYVEAKRSMVSSVAQIPVWMYGVLVVLGWNEAMAVLFNPLYFAMLLVLAASGYIILQLGLAGPILQIAGTVIREIRQIAAKKLREAFADVPEAQRVLARPVTASSSDGQERKGDLLKGEMLEK
Protein: Cadherin-6 (Kidney cadherin) (K-cadherin) (P55280)
Organism: Rattus norvegicus (Rat)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Catenin alpha-1
- Catenin beta-1
- Cadherin 3
- Cadherin-2
Sequence:
MRTYRYFLLLFWVGQPYPTFSNPLSKRTSGFPAKRRALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHDMFDVITDQETQEGIITVKKLLDFEKKRVYTLKVEASNPHIEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKPAYILQIREDAQINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPKPWRQQSRRDMVPEALFLPRRTPTARDNTDVRDFISQRLRKMNTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDGDQDYGYLSDWGPRFKKLADMYGGMDSDKDS
Protein: Spectrin beta, non-erythrocytic 4 (D3YWH8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVVGDTRFHSLCCNALPPPMAQVPGEVDNMEGPAVSNNNNPSARWESPDRGWDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEVLSGEQLV
Protein: Derlin-1 (DER1-like protein 1) (Q9VQ57)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BUN8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BUN8}.
Interaction partners:
- E3 ubiquitin-protein ligase HRD1
- Endoplasmic reticulum lectin 1
- Derlin
- HMG-coA reductase degradation 3, isoform A
- Nuclear protein localization protein 4 homolog
- Ubiquitin fusion degradation protein 1 homolog
- Transitional endoplasmic reticulum ATPase TER94
- Endoplasmic reticulum chaperone BiP
- GM09977p
- Argus, isoform A
Sequence:
MDAGVWYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISSNTAFHFLINCFFIVQYSSKLEKDQYSRSPADYLYLLIVSAVLANIGGMIFNVYFLMDTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFSLASLVGIFVGHVYYFFKFQYSQDLGGTPLLETPQFLKRLVPDVSGGFGGFGLPPESRAPPRQATESPWGRGMTLGRN
Protein: Neither inactivation nor afterpotential protein G (EC 1.-.-.-) (Q9VGP2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Carotenoid isomerooxygenase
- Retinol-binding protein pinta
- FI02050p
- Scavenger receptor acting in neural tissue and majority of rhodopsin is absent, isoform A
- Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme
Sequence:
MGMKFQKILVLAGIVIGFLSIIVVLAGTLLKNSVPNVLAPVERHFAFDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFLSVPQKHSSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQMRSFMAAAKPKNPDMLEIPRRYSKLTEALEEAQAQFAYKDWIFRRSLYNIRNGLRHSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSILVGIKDEENREKEFSIELLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHFNLPLFVSMGVTGPTLNQNTLLNPMTLINYLSSGSGPLGNFGVLGNVVSYGGLGAPPYGITFFGAGAIDESALMSISNFKGPAFRALFPRYYNSSQEGFVVISSCLQPKSRGSVGLLNRHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECSNFGPFERDFFDNRPSDQYLECLMRHVGLGSHHPGGTCALGSVVDSQLRLKGVSNVRVVDASVLPRPISGNPNSVVVAIALRAASWILKSELQAGDSK
Protein: Zygotic gap protein knirps (Nuclear receptor subfamily 0 group A member 1) (P10734)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcriptional repressor. Binds to multiple sites in the eve stripe 3 enhancer element. Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:8670869}.
Interaction partners:
- Protein hunchback
- Huckebein
- Segmentation protein even-skipped
- Homeotic protein bicoid
- Segmentation protein fushi tarazu
- C-terminal-binding protein
- Protein twist
- Smrter, isoform G
- Knirps-related protein
- Segmentation protein paired
Sequence:
MNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNISTISECKNEGKCIIDKKNRTTCKACRLRKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSASSPVGSPHTPGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGGVPHQSPFQLPPHLLFPGYHASAAAAAASAADAAYRQEMYKHRQSVDSVESQNRFSPASQPPVVQPTSSARQSPIDVCLEEDVHSVHSHQSSASLLHPIAIRATPTTPTSSSPLSFAAKMQSLSPVSVCSIGGETTSVVPVHPPTVSAQEGPMDLSMKTSRSSVHSFNDSGSEDQEVEVAPRRKFYQLEAECLTTSSSSSSHSAAHSPNTTTAHAEVKRQKLGGAEATHFGGFAVAHNAASAMRGIFVCV
Protein: CheY6 protein (Response regulator) (Q8KLS1)
Organism: Cereibacter sphaeroides (Rhodobacter sphaeroides)
Interaction partners:
Sequence:
MPYNVMIVDDAAMMRLYIASFIKTLPDFKVVAQAANGQEALDKLAAQPNVDLILLDIEMPVMDGMEFLRHAKLKTRAKICMLSSVAVSGSPHAARARELGADGVVAKPSGTVSHDLEEKTGGELARTMRTLMAA
Protein: Large ribosomal subunit protein mL39 (39S ribosomal protein L39, mitochondrial) (L39mt) (MRP-L39) (Q9JKF7)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9NYK5}.
Interaction partners:
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL1m
- Small ribosomal subunit protein mS31
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL32m
- Large ribosomal subunit protein mL45
- Large ribosomal subunit protein mL50
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein uL13m
Sequence:
MATAVGRLVLRRPGAGGGARWRFIATSPAAELSPTELTEMRNDLFNREKSRQLSLTPRTEKIEVKHVGKTDPGTVFVMNKNISTPYSCAMHLSEWYCSKSILALVDGQPWDMYKPLTKSCEIKFLTFKDPDPKEVNKAYWRSCAMMLGCVIERAFKDDYVVSLVRAPEVPVIAGAFCYDVTLDKRLDEWMPTKENLRSFTKDAHALIYRDLPFETLDVDARVALEIFQHNKYKVDFIEEKASQNPERIVKLHRIGDFIDVSEGPLIPRTSVCFQYEVSAVHNLNPSQPNLIRRFQGLSLPTHLRAQFTIWDKLVERSRKMVTEDEVRQTENTESTQ
Protein: CLAVATA3/ESR (CLE)-related protein 18 [Cleaved into: CLE18p; CLE18 C-terminus] (Q3ECH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Root growth factor that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells.
Subcellular location: [CLE18p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.; SUBCELLULAR LOCATION: [CLE18 C-terminus]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- Protein GOLVEN 8
- CLAVATA3/ESR
Sequence:
MHLLKGGVVLIITLILFLITSSIVAIREDPSLIGVDRQIPTGPDPLHNPPQPSPKHHHWIGVEENNIDRSWNYVDYESHHAHSPIHNSPEPAPLYRHLIGV
Protein: Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (Q6IPH7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRNRIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAAAAAAKVPAKKITAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA
Protein: Monothiol glutaredoxin-S9 (AtGrxS9) (Protein ROXY 7) (O04341)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Putative pectinesterase
- Glutaredoxin family protein
- UDP-glycosyltransferase 79B5
- Cytochrome P450 71B22
- Probable acyl-activating enzyme 12, peroxisomal
- Thioredoxin H9
Sequence:
MDKVVRMSSEKGVVIFSKSSCCMSYAVQVLFQDLGVHPTVHEIDKDPECREIEKALMRLGCSTPVPAIFVGGKLIGSTNEVMSLHLSGSLVPLVKPFQANLC
Protein: Pyruvate/proton symporter BtsT (Brenztraubensaure transporter) (Pyruvate/H(+) symporter) (P39396)
Organism: Escherichia coli (strain K12)
Function: Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Under nutrient limiting conditions, mediates the uptake of pyruvate, thus enabling it to be used as a carbon source for the growth and survival. Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22685278, ECO:0000269|PubMed:29061664}; Multi-pass membrane protein {ECO:0000305|PubMed:29061664}.
Interaction partners:
- Uncharacterized protein YjiX
- Zinc chaperone YjiA
- Sensor histidine kinase BtsS
- Uncharacterized protein YbdD
- Transcriptional regulatory protein BtsR
- Transcriptional regulatory protein YpdB
- Uncharacterized MFS-type transporter YhjX
- Sensor histidine kinase YpdA
Sequence:
MDTKKIFKHIPWVILGIIGAFCLAVVALRRGEHISALWIVVASVSVYLVAYRYYSLYIAQKVMKLDPTRATPAVINNDGLNYVPTNRYVLFGHHFAAIAGAGPLVGPVLAAQMGYLPGTLWLLAGVVLAGAVQDFMVLFISSRRNGASLGEMIKEEMGPVPGTIALFGCFLIMIIILAVLALIVVKALAESPWGVFTVCSTVPIALFMGIYMRFIRPGRVGEVSVIGIVLLVASIYFGGVIAHDPYWGPALTFKDTTITFALIGYAFVSALLPVWLILAPRDYLATFLKIGVIVGLALGIVVLNPELKMPAMTQYIDGTGPLWKGALFPFLFITIACGAVSGFHALISSGTTPKLLANETDARFIGYGAMLMESFVAIMALVAASIIEPGLYFAMNTPPAGLGITMPNLHEMGGENAPIIMAQLKDVTAHAAATVSSWGFVISPEQILQTAKDIGEPSVLNRAGGAPTLAVGIAHVFHKVLPMADMGFWYHFGILFEALFILTALDAGTRSGRFMLQDLLGNFIPFLKKTDSLVAGIIGTAGCVGLWGYLLYQGVVDPLGGVKSLWPLFGISNQMLAAVALVLGTVVLIKMKRTQYIWVTVVPAVWLLICTTWALGLKLFSTNPQMEGFFYMASQYKEKIANGTDLTAQQIANMNHIVVNNYTNAGLSILFLIVVYSIIFYGFKTWLAVRNSDKRTDKETPYVPIPEGGVKISSHH