wanglab/gogpt-training-data huggingface dataset:
Protein: Potassium channel GORK (Guard cell outward rectifying K(+) channel) (AtGORK) (Q94A76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Major selective outward-rectifying potassium channel of the guard cell membrane. Involved in regulation of stomatal movements according to the water status. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization. Conductance of the channel is modulated in a potassium-dependent fashion. May interact with the cytoskeleton or with regulatory proteins.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Guard cell S-type anion channel SLAC1
- Aluminum-activated malate transporter 12
- Potassium transporter 5
- Potassium transporter 6
- S-type anion channel SLAH3
- Two-pore potassium channel 4
- Calcium-dependent protein kinase 21
- Potassium inward rectifier
- ATPase 5, plasma membrane-type
- Serine/threonine-protein kinase SRK2E
Sequence:
MGRLRRRQEIIDHEEEESNDDVSSRRGKLSLAETFRWLDSSEHRRIETDGHNDYKYIIHPKNRWYKAWEMFILVWAIYSSLFTPMEFGFFRGLPERLFVLDIVGQIAFLVDIVLQFFVAYRDTQTYRTVYKPTRIAFRYLKSHFLMDFIGCFPWDLIYKASGKHELVRYLLWIRLFRVRKVVEFFQRLEKDTRINYLFTRILKLLFVEVYCTHTAACIFYYLATTLPPENEGYTWIGSLKLGDYSYENFREIDLWKRYTTALYFAIVTMATVGYGDIHAVNLREMIFVMIYVSFDMVLGAYLIGNITALIVKGSNTERFRDKMNDLISFMNRKKLGRDLRSQITGHVRLQYDSHYTDTVMLQDIPASIRAKIAQLLYLPYIKKVPLFKGCSTEFINQIVIRLHEEYFLPGEVITEQGNVVDHLYFVCEGLLEALVTKTDGSEESVTLLGPHTSFGDISIICNISQPFTVRVCELCHLLRLDKQSFSNILEIYFHDGRTILNNIMEEKESNDRIKKLESDIVIHIGKQEAELALKVNSAAFQGDFYQLKSLIRSGADPNKTDYDGRSPLHLAACRGYEDITLFLIQEGVDVNLKDKFGHTPLFEAVKAGQEGVIGLLVKEGASFNLEDSGNFLCTTVAKGDSDFLKRLLSSGMNPNSEDYDHRTPLHVAASEGLFLMAKMLVEAGASVISKDRWGNSPLDEARLCGNKKLIKLLEDVKNAQSSIYPSSLRELQEERIERRKCTVFPFHPQEAKEERSRKHGVVVWIPSNLEKLIVTAAKELGLSDGASFVLLSEDQGRITDIDMISDGHKLYMISDTTDQT
Protein: Alpha-factor pheromone receptor (A0A1D8PTB4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Mating pheromone alpha
- Guanine nucleotide-binding protein subunit alpha
- G protein subunit beta
- ATP-binding cassette alpha-factor transporter
- Guanine nucleotide-binding protein subunit gamma
- GTPase-activating protein
- Ste3p
- E3 ubiquitin-protein ligase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
Sequence:
MNINSTFIPDKPGDIIISYSIPGLDQPIQIPFHSLDSFQTDQAKIALVMGITIGSCSMTLIFLISIMYKTNKLTNLKLKLKLKYILQWINQKIFTKKRNDNKQQQQQQQQQIESSSYNNTTTTTSGSYKLFLFYLNSLILLIGIIRSGCYLNYNLGPLNSLSFVFTGWYDGSSFISSDVTNGFKCILYALVEISLGFQVYVMFKTSNLKIWGIMASLLSIGLGLIVVAFQINLTILSHIRFSRAISTNRSEEESSSSLSSDSVGYVINSIWMDLPTILFSISINIMTILLIGKLIIAIRTRRYLGLKQFDSFHILLIGFSQTLIIPSIILVVHYFYLSQNKDSLLQQISLLLIILMLPLSSLWAQTANNTHNINSSPSLSFISRHHSFDSSRSGGSNTIVSNGGSNGGGGGGNFPVSGIDAQLPPDIEKILHEDNNYKLLNSNNESVNDGDIIINDEGMITKQITIKRV
Protein: HSP90B1 protein (Q96GW1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAARRR
Protein: UBP3-associated protein BRE5 (Brefeldin-A sensitivity protein 5) (P53741)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in de-ubiquitination. In conjunction with UBP3, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of sec23.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 3
- Protein NAM8
- U1 small nuclear ribonucleoprotein A
- Cell division control protein 48
- Protein DOA1
- Large ribosomal subunit protein uL23
- Zinc finger protein GIS2
- Small ribosomal subunit protein RACK1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22
Sequence:
MGVTVQDICFAFLQNYYERMRTDPSKLAYFYASTAELTHTNYQSKSTNEKDDVLPTVKVTGRENINKFFSRNDAKVRSLKLKLDTIDFQYTGHLHKSILIMATGEMFWTGTPVYKFCQTFILLPSSNGSTFDITNDIIRFISNSFKPYVLTDASLSQSNEENSVSAVEEDKIRHESGVEKEKEKEKSPEISKPKAKKETVKDTTAPTESSTQEKPIVDHSQPRAIPVTKESKIHTETVPSSTKGNHKQDEVSTEELGNVTKLNEKSHKAEKKAAPIKTKEGSVEAINAVNNSSLPNGKEVSDEKPVPGGVKEAETEIKPIEPQVSDAKESGNNASTPSSSPEPVANPPKMTWASKLMNENSDRISKNNTTVEYIRPETLPKKPTERKFEMGNRRDNASANSKNKKKPVFSTVNKDGFYPIYIRGTNGLREEKLRSALEKEFGKVMRITAADNFAVVDFETQKSQIDALEKKKKSIDGIEVCLERKTVKKPTSNNPPGIFTNGTRSHRKQPLKRKD
Protein: Kinase suppressor of Ras 1 (EC 2.7.11.1) (Q8IVT5)
Organism: Homo sapiens (Human)
Function: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000269|PubMed:20679487}; Peripheral membrane protein {ECO:0000269|PubMed:20679487}. Cell membrane {ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305|PubMed:12007434}.
Interaction partners:
- RAF proto-oncogene serine/threonine-protein kinase
- Lymphocyte-specific protein 1
- Dual specificity mitogen-activated protein kinase kinase 1
- BRCA1-associated protein
- Dual specificity mitogen-activated protein kinase kinase 2
- MAP/microtubule affinity-regulating kinase 3
- CD209 antigen
- Connector enhancer of kinase suppressor of ras 1
- Serine/threonine-protein kinase B-raf
- Kinase suppressor of Ras 2
Sequence:
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM
Protein: SOUL heme-binding family protein (F4IRX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box protein At1g70590
- Uncharacterized protein AT4g35690
- Tetratricopeptide repeat
- At4g12840
- MIF4G domain-containing protein
- At4g27620
- Probable diphthine methyl ester synthase
- At3g27230
- Pentatricopeptide repeat
- Protein involved in starch initiation 1
Sequence:
MLTTRLRLVTERTKLINTTSPMRIVFGKTYIMGMVFGKIAVETPKYTVTKSGDGYEIREYPPAVAAEVTYDASEFKGDKDGGFQLLAKYIGVFGKPENEKPEKIAMTAPVITKEGEKIAMTAPVITKESEKIEMTSPVVTKEGGGEGRKKLVTMQFLLPSMYKKAEEAPRPTDERVVIKEEGGRKYGVIKFSGIASESVVSEKVKKLSSHLEKDGFKITGDFVLARYNPPWTLPPFRTNEVMIPVE
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FJU2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Transcription factor
- Calcium-channel protein CCH1
- Candida glabrata strain CBS138 chromosome J complete sequence
- mitogen-activated protein kinase kinase
- Candida glabrata strain CBS138 chromosome M complete sequence
Sequence:
MLLWVLFLYLLASGSAFRFGGNDSWWNRRDLAAGGSEVAVDMQLLDIVNKADGGSTSTSSDVGASSSAQSNADDTNGDGDDDDGDDDDDDDGEDEPQIINSNLIYEWTPIISKMTPGKVDNYMFNINPESTGLGFAPSYEILIFLSGNICQQPTNSTDLQIRVYYSFDEKMLSNISLGNFETFSNGYLEALQISPVNHTSNGTTLNSKNLYVSVRLWDLINDKEVDKDDPNIKNLTSTEWDYRLSISENDLVFQWDTRSWIDVLDTDSTSALISTGNVTDDGQIYSNYTIYDPTLYDLYLYTYDEYQKFLNVSELSLCAIKNGPHLVSSEGASATNPPLEMLQETGLKIQKRIAESSSGIAEQFYITGLTPNTTYAAFLTKKIGKGQSLSNVGGVLFDAEIFTTQTSDACSLIFGMSFCSDNAYSVPSSEFTNGNKSDLAIEYDNIASALYSNFSKALQLVPCDADLDARYSPIRTCDDCATSYRDWICAVSIPRCSTTESSSYIYRSKTDNRNSYVNKFIKPTEDYYEVLPCIDMCYAIVRDCPSVFNFKCPDQESEPELLFQSYNIFKQSSPFITCNFIGNASYLKIHK
Protein: Mdm2-binding protein (mMTBP) (Q8BJS8)
Organism: Mus musculus (Mouse)
Function: May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells.
Interaction partners:
- Treslin
- ATP-dependent DNA helicase Q4
- E3 ubiquitin-protein ligase Mdm2
- DNA topoisomerase 2-binding protein 1
- Cell division control protein 45 homolog
- TATA-box-binding protein
Sequence:
MDRYLLLVTWREGKFRSVAGGEIEPGTEATSLESTDKQPDLTATNIYHLLKRSISDSIHPDDSTFPACSVGGTPHSRKWFFAVQAICGFYQFCSSDWQEIHFDAEKDKIEDVLQANIEECQSAVECFEEDDSNSRESLPLADLYEESAENLHQLSDKLPAPGRAMIDIILLPSDKDPPKLKECLPIVGALKHLKEWHSAKVIIAGSYCEINCQKIAEYLSASVVPLEEFRNAIDPRELWRGEIQMRERKFGFEISFPEFCLKGVTPTNVSAYNLNTCFLAKKIASSKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELEVTGHCTRQNSMLLLEQISSLCGKVGALFVLPCTVSNVLIPPPSQLASRKWKEYMAKKPKTISVPDVAVKGEFSGYHLLLQGMGKRKCRATLLHSASQINGSFALSVIHGKMKTKAGEARPSFPFDFSSLPRFSEEQVLQREKQLASFQVLALKECLKRRKAANQPEAFSADELKSLLALTRERFLGHFDVLPTEAALAQTDTVKAAGVVNDDGTVEPYSSSLMETNPLEWPERHVLQNLETSEKAKQKMRTGSLPRSSEQLLGHKEGPRDSLTLLDAKELLKYFTSDGLPVGDLQPLHIQRGEKPFVLTPELSPGKLQVLPFEKASECHYHGIEYCLDDQKALERDGGFSELQSRLIRYETQTTCTRDSFPVPTVLSPLPSPAVLSEPQSVPEGEALQGELRTEVSGLKRRSKDPSCLYPQKRLTRSESSDCLPSQASCNSNHHHHTGKPRKPQAERCVSGLPLPGREASKDTSKTSSGQKRAHESKSSKQMKESRSQKHTRMLKEVVKDTLKRHHITEAHESFTACSQRLFDISKFYLKDLKTSRGLFEEMKKTANNNVVQVIEWVVEKMSKK
Protein: Sulfite reductase [NADPH] hemoprotein beta-component (SiR-HP) (SiRHP) (EC 1.8.1.2) (P17846)
Organism: Escherichia coli (strain K12)
Function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Interaction partners:
- Adenylyl-sulfate kinase
- Phosphoadenosine 5'-phosphosulfate reductase
- Sulfite reductase flavoprotein alpha-component
- Sulfate adenylyltransferase subunit 2
- Sulfate adenylyltransferase subunit 1
- Sulfate/thiosulfate import ATP-binding protein CysA
- Cysteine synthase A
- Siroheme synthase
- Sulfate transport system permease protein CysW
- Thiosulfate-binding protein
Sequence:
MSEKHPGPLVVEGKLTDAERMKHESNYLRGTIAEDLNDGLTGGFKGDNFLLIRFHGMYQQDDRDIRAERAEQKLEPRHAMLLRCRLPGGVITTKQWQAIDKFAGENTIYGSIRLTNRQTFQFHGILKKNVKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLLPRTRAYAEIWLDQEKVATTDEEPILGQTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLSIEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDNWHLTLFIENGRILDYPARPLKTGLLEIAKIHKGDFRITANQNLIIAGVPESEKAKIEKIAKESGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFIDNIDNLMAKHGVSDEHIVMRVTGCPNGCGRAMLAEVGLVGKAPGRYNLHLGGNRIGTRIPRMYKENITEPEILASLDELIGRWAKEREAGEGFGDFTVRAGIIRPVLDPARDLWD
Protein: WRKY transcription factor WRKY51 (OsWRKY51) (Q0JEE2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor. Interacts, when in complex with WRKY71, specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Represses specifically gibberellic acid (GA)-induced promoters in aleurone cells, probably by interfering with GAM1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223, ECO:0000269|PubMed:16623886}. Note=Localized in nuclei of aleurone cells. {ECO:0000269|PubMed:16623886}.
Interaction partners:
Sequence:
MITMDLMGGYGRVDEQVAIQEAAAAGLRGMEHLILQLSQTGTSERSPAPAQEQQQQVDCREITDMTVSKFKKVISMLNRTGHARFRRGPVVAQSSGPAASEPAPVRSSPSAVSRPMTLDFTKAASGYGKDAGFSVSGISAASSSFLSSVTGDGSVSNGRGGGSSSLMLPPPPATSCGKPPLSSAAAAMSAGAGHKRKCHDHAHSENVAGGKYGSTGGRCHCSKRRKHRVKRTIRVPAISSKVADIPADDFSWRKYGQKPIKGSPFPRGYYKCSTLRGCPARKHVERDPTDPSMLIVTYEGEHRHSPSAAGQDHPPAPPPPLALPLA
Protein: small monomeric GTPase (EC 3.6.5.2) (B5X794)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVDEIFYDRVRQINRKTPIEKKKAKKKSNCTLL
Protein: Ethylene-responsive transcription factor ERF010 (Q9FH94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 67
- Ras-related protein RABH1e
Sequence:
MEGGGVADVAVPGTRKRDRPYKGIRMRKWGKWVAEIREPNKRSRLWLGSYSTPEAAARAYDTAVFYLRGPTARLNFPELLPGEKFSDEDMSAATIRKKATEVGAQVDALGTAVQNNRHRVFGQNRDSDVDNKNFHRNYQNGEREEEEEDEDDKRLRSGGRLLDRVDLNKLPDPESSDEEWESKH
Protein: Protein transport protein sec13 (Q5B563)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Sec13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q04491}.
Interaction partners:
- Nucleoporin NSP1
- Protein transport protein sec23
- Protein transport protein sec31
- Protein transport protein sec24
- Nuclear pore complex protein An-Nup133
- Nuclear pore complex protein
- Peptidase S59 domain-containing protein
- WD40 protein related to S. cerevisiae SEH1
- WD repeat protein
- COPII coat assembly protein sec16
Sequence:
MAAAQVISNSGHDDMIHDAGLDYYGRRLATCSSDKTIKIFEIEGDTHKLVETLKGHEGPVWCVEWAHPKFGTILASSSYDGKVLIWREQHQSSTAPIGSGAWTKVFDFSLHTASVNMISWAPHETGCLLACASSDGHVSVLEFRDNSWTHQIFHAHGMGVNSISWAPAASPGSLVSSNPGIGQQRRFVTGGSDNLLKIWDYNPETKTYNATQTLEGHSDWVRDVAWSPSILSKSYIASASQDKTVRVWTADASNPGQWTSQVLEFDNVLWRVSWSPSGNILAVSGGDNKVSLWKENLRGQWEKVKDIEE
Protein: Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) (O08712)
Organism: Mus musculus (Mouse)
Function: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Subcellular location: Secreted.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 11
- Tumor necrosis factor ligand superfamily member 10
- Transcription factor Sp7
- Runt-related transcription factor 2
- Collagen alpha-1
Sequence:
MNKWLCCALLVLLDIIEWTTQETLPPKYLHYDPETGHQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDHSYTDSWHTSDECVYCSPVCKELQSVKQECNRTHNRVCECEEGRYLEIEFCLKHRSCPPGSGVVQAGTPERNTVCKKCPDGFFSGETSSKAPCIKHTNCSTFGLLLIQKGNATHDNVCSGNREATQKCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHLGHSNLTTEQLLALMESLPGKKISPEEIERTRKTCKSSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKTSHFPKTVTHSLRKTMRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
Protein: Cullin 2 (A0A8I6G8I6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYAETKIFLENHVRHLYKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHSECHSIIRHERKNDMANMYVLLRAVSSGLPHMIEELQRHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
Protein: Cyclin-O protein B (Q32NM1)
Organism: Xenopus laevis (African clawed frog)
Function: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of mcidas to promote mother centriole amplification and maturation in preparation for apical docking.
Subcellular location: Cytoplasm {ECO:0000250}. Note=Localizes to the apical part of cytoplasm. {ECO:0000250}.
Interaction partners:
Sequence:
MVTCSMRCTEEGLLGATLAFSSGKRKRDSVYSPGDATPGDRGEGEPKCPSVGTKKRAKYSRHRKQSLELRSCDSGVADLYETPSPSPVAPSPTHEPWDTCTPMYDGLGLQNFRDYGQDCYTFNKSLEDKFLAVNCLKNQPQIQAESRCKLISWLIPVHRHLNLGFESLCLTVNILDRFLACTPVASDCFQLVGVTSLLIASKQVETRPPRVKQLLALCCDAFSREQLCNLECIILLKLHFRLGAPTINFFLQHFSLLRVTNEESSDTELSETTKSVTVARGIAELSLADYAFNSYSPSLMAVCCLEIADRMLCHRNPIRARVSDYHESLIQECVGKIDLLVSLNQDSLHRLLPSQFAVKSINVDN
Protein: Decapping enzyme complex catalytic subunit (A0A1D8PTQ2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 5'-3' exoribonuclease 1
- mRNA-decapping enzyme subunit 1
- ATP-dependent RNA helicase DHH1
- Enhancer of mRNA-decapping protein 3
- mRNA decay factor PAT1 domain-containing protein
- NAD
- U6 snRNA-associated Sm-like protein LSm4
- CCR4-NOT core DEDD family RNase subunit
- U6 snRNA-associated Sm-like protein LSm1
- 5'-3' exoribonuclease 2
Sequence:
MSIQLRNGLANQTLDRVLEDLLVRFVVNVPEEDLSSIERIMFQIEEAQWFYADFVRQLNPDLQSMKMKTFSTKILEKCPLIWKWGDPQEALSKFGKYKSTIPVRGVALFNKDLNKVVLVKGTESNSWSFPRGKISKDESDIDCAVREVEEETGFNCRHLIDENDCIERNIRGKNYKIYLVKNVPEDTLFEAPTYEISQIKWFDIKTIQKKCKTNPNTFFIVGTILKPMTKWINKNKGVLNEEEIMLQVELKLKELLGLNAKEPEENVDAGRELLNILQKVGQKESQSAISPSSSYQNNDQQPQPPMVNVPVPQHLHNQIPFFAGAHAAFPFYNQPFFNPMSFMPPQFMPHHPAYVSPHNQQPPNPQSFQKPKTNSKELLSILTAKSDKKRDDENSKQRKPVEDDNIRSRAQQLLSVFPKKHIKETNTSAESEVENENELAKKHLLKSLRRSATPEASTTETRSPGMSPIIDNSYQEPSNEIEESIRAQRQQVPVTSRRKIKLLKRSDNEASANLLELLGPKKTESVDTANKNPDAGNELLGLLHKKQEQNQESLPNVERSSTRKEESQNTSNELLTMLKKPTAAKESTSESRSQNLLNLLKKPESQNAPGSKGKDQASGDQLADTHLPSYTQNNLQPQLNNLNPLPSPMNFLSSPEQKPQQASQVSSANQLLGLLHKNGTERNKSITSPNELWGTSTPGSTGGPSVGEANKHSNATTGGPFRSNVLSPNLDIWTNDTKTSSLSGSQFQIPEPSRRSSQLLDLLNTNRDPVQDAQYSQSNSNNYNNGGIEIARRDSPSDKFENFEDFEDYNDGYQFNDELLDKTYRNFDIASDEEDVDYLIDPLITHNDKSSHQDNEIKPSSVDNQNDQPKKIRILKPGENIDNLFGSQGSNEPGKGLLALLNGGKAQ
Protein: Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1) (Q8TDF5)
Organism: Homo sapiens (Human)
Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
Subcellular location: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250}. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 2
- Glutamate receptor ionotropic, kainate 1
- Glutamate receptor ionotropic, NMDA 2A
- Lysine--tRNA ligase
- Glutamate receptor ionotropic, kainate 4
Sequence:
MIHGRSVLHIVASLIILHLSGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKTSLLDQLTNTSGTVIGVTSCIVIILIIISVIVQIKQPRKKYVQRKSDFDQTVFQEVFEPPHYELCTLRGTGATADFADVADDFENYHKLRRSSSKCIHDHHCGSQLSSTKGSRSNLSTRDASILTEMPTQPGKPLIPPMNRRNILVMKHSYSQDAADACDIDEIEEVPTTSHRLSRHDKAVQRFCLIGSLSKHESEYNTTRV
Protein: SWM histone demethylase complex subunit phf2 (PHD finger domain-containing protein phf2) (Q09908)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Lysine-specific histone demethylase 2
- Lysine-specific histone demethylase 1
- SWM histone demethylase complex subunit phf1
- Uncharacterized RNA-binding protein C23E6.01c
Sequence:
MPNSSYYDDDGGSFEAASYPFQFDGSRRFPNDLHPTMFEGEESNQNGGSVLIDQAFQDIQNPNVNSNMHLENQFQHFHEPNKESGAFGSYKNDDVAKEIESSKNQETDAKSEQAPFTEDASSSNYAHHRSADSQTKSALPPNVPASSSPLPPMSIAMNIARKRSWPASLAIERDNTADALFSTEDGREEQFNLEGVKTKSGRKVHRPNHFDPLVKLPTRRRGPGRRPVVALAMKCSVCQRLQSPPKNRIVFCDGCNTPFHQLCHEPYISDELLDSPNGEWFCDDCIRRKKQAPLVTGTTARELNLSSEEKKSYLLSLPISQLVDILLFCEQLHPDIPFYSPKTSTIVQELQSKRSAFTATMNEPVTGDQYLSLNNGTESQSKTTKHSTSLPSTEPVEVDKQYMESEKIPTIDEYLQEYSNEDEIVLQVLESFPAAVSFSTITNTIQAKYSNRKIKNSNITRSLNRLVRKNRVLRDARGSSYELNRTFDADRPSVRPDISITGPIPIDWMLYTPHTEDLTENFCTYYMFDETPIVLSSI
Protein: Opsin-VA-like (Vertebrate ancient long opsin) (F7CHJ2)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
- Uncharacterized protein.
- Splicing factor 3b subunit 1.
- Homeobox A3.
- CPSF_A domain-containing protein.
- Pyroglutamyl-peptidase I like.
- STT3B, catalytic subunit of the oligosaccharyltransferase complex.
- Small nuclear ribonucleoprotein polypeptide A.
- LOC100170460 protein
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein E
Sequence:
MPTNVSLLATPENSTVWNPFTGPLKTIEAWNFHLLAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFFGIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWSSYTTSKIGTTCEPNWYSGEMRDHTYIITFLTTCFVFPLLVIFMSYGKLMRKLRKVSDTQGRLGSTRKPEKEVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQFRRCLYQMFNINDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHITSSAVTNREEEKSSSNSFAHIPVSDNKVCPM