wanglab/gogpt-training-data huggingface dataset:
Protein: Shootin-1 (Q6P0R8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth.
Subcellular location: Perikaryon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8K2Q9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, filopodium {ECO:0000250|UniProtKB:A0MZ67}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:A0MZ67}.
Interaction partners:
- Doublecortin domain-containing 2B.
Sequence:
MASKGKKNKVRTNSDLSNQVLLQYESLQKEHEKIKKECKKLQEERDEALRKLNEFESVSHRVIEEVNSIQENLEIEKTCRESVEALASKLNRQNLSLKRKSMLYMSRLAADVVAEISIDDEDDEDAHEEEAGVCSSSHCHIVITELRDKLEEILATKKQLMIDLETTREQLSKTRQELLKEKHDNTVLIAETFQQKKLLGKYNRVSQYALDEFESLQEDLKLERDLRSEAEKFAHEMLIEQKKLKRQSQVLVQSISVGEALQKALAEISTLTHTLEKQRLEHQQQVKGLEEQVNSSEVKKQLTALQRQTDLLEEERKEWQHKHTKAETEAKDLRFTVEELKKKLQQVSNPPTAAPAPPPPPPPPPPPPPPSSSSSNPLSSLLSILRKKKDVSTEIALVEKDSSEKSPEKDVRQQAVDEMMLRIKKGVQLRPVSQTTNRVRPGPKEPTASNSAIQELQGILNTVKRPGPSSSPGPRPPSPSEKSELEKALQRRREAVKSAKNNTNPSSVVDLTQIKQTRSEPGQNTGDQETLRHTTTTICTEQLS
Protein: Protein SPIRAL1 (Protein NAP16kDa) (Q9SJW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for directional control of cell elongation. Stabilizes growing ends of cortical microtubules and influences their dynamic properties. Acts redundantly with SP1Ls in maintaining the cortical microtubules organization essential for anisotropic cell growth. Plays a key role in salt stress-induced microtubules disassembly.
Subcellular location: Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:15155883}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15155883}.
Interaction partners:
- Microtubule-associated protein RP/EB family member 1B
- Microtubule-associated protein TORTIFOLIA1
- Microtubule-associated protein RP/EB family member 1A
- Protein WAVE-DAMPENED 2
- At3g53320
- TRIO/F-actin-binding protein
- CLIP-associated protein
- Plasma membrane-associated cation-binding protein 2
- Protein WVD2-like 3
- Monocopper oxidase-like protein SKU5
Sequence:
MGRGNSCGGGQSSLDYLFGGDAPAPKPVPAPRPAPTESNNGPAPPVTAVTATALTTATTSVEPAELNKQIPAGIKTPVNNYARAEGQNTGNFLTDRPSTKVHAAPGGGSSLDYLFTGGK
Protein: Developmental protein SEPALLATA 3 (Agamous-like MADS-box protein AGL9) (O22456)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor active in inflorescence development and floral organogenesis. Functions with SEPALLATA1/AGL2 and SEPALLATA2/AGL4 to ensure proper development of petals, stamens and carpels and to prevent the indeterminate growth of the flower meristem. Interacts with APETALA1, AGAMOUS or APETALA3/PISTILLATA to form complexes, that could be involved in genes regulation during floral meristem development. Binds specifically to the CArG box DNA sequence 5'-CC (A/T)6 GG-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Floral homeotic protein APETALA 3
- Agamous-like MADS-box protein AGL11
- Floral homeotic protein AGAMOUS
- Transcriptional corepressor SEUSS
- Protein LEAFY
- Agamous-like MADS-box protein AGL1
- Transcriptional corepressor LEUNIG
- Agamous-like MADS-box protein AGL5
- Floral homeotic protein APETALA 1
- Floral homeotic protein APETALA 2
Sequence:
MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSSSMLRTLERYQKCNYGAPEPNVPSREALAVELSSQQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRTQFMLDQLNDLQSKERMLTETNKTLRLRLADGYQMPLQLNPNQEEVDHYGRHHHQQQQHSQAFFQPLECEPILQIGYQGQQDGMGAGPSVNNYMLGWLPYDTNSI
Protein: Cadherin 4, retinal (Cadherin-4 isoform 2 precursor) (A4IGF0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAKMKTGCAILVACALVVGTSLGSHWNAQTVAPCRPGSSQSFYTVFVPRVVLQGLNIHKGKSLQCIAQFGAGLYVCVCVNLSGGLATGLWVNTNARVSLPLPFSVCVG
Protein: AT3g20370/MQC12_13 (TRAF-like family protein) (Q9LTQ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein P2x
- At3g27200
- Jacalin-related lectin 34
- Squamosa promoter-binding-like protein 2
- Zinc finger protein CONSTANS-LIKE 2
Sequence:
MASHYRNTSAIAYLLLCLFITSATAHSFIRQITDDLKTNLQQEVGAEPIQNLDVGHYLQENKEISSRDYKVSASNAVKGLRDRPPSSYSLKMESFNTLLKSTYTEKYVSRPFSVGGYNWTLVVFPNGNKKDSGSGYLSLYVAIDNSTLGQQEIYADLRFYIFNKNERKYFTIQDTDVWKFSVFKTMWGFSQVLPIDTFKDPTKGYLYDGDHCEFGVDVTMPSLYEKSELFSVTENFLNPRFTWTIRGFSTLLKNSYLSEVFSIGGRSWNIQINPSGLGTGEGKALSMYLGLNVNEIFRPYEKIYVRAKLRALNQLNLSNIERELDIWYNGPGYGEYSWGFPEFIYFPYLTDSSKGFVKNDVLMVQVEMEAISSTKYFPS
Protein: Alpha-L-fucosidase 3 (EC 3.2.1.51) (Alpha-1,2-fucosidase) (AtFXG1) (Alpha-L-fucoside fucohydrolase 3) (Q9FXE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes alpha-1,2-linked fucose. Also active on fucosylated xyloglucan oligosaccharides.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:11788770, ECO:0000269|PubMed:16267099}.
Interaction partners:
- Alpha-L-fucosidase 2
- Alpha-L-fucosidase 1
- F-box protein At1g60400
- Nucleotidyltransferase family protein
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7
- 1-aminocyclopropane-1-carboxylate oxidase homolog 10
- Alpha-xylosidase 1
- Homeobox-leucine zipper protein HDG3
- F-box protein At1g11810
- Uncharacterized protein
Sequence:
MNPILSSLFALSLLSSLSPSTHAHQCHFPAIFNFGDSNSDTGGLSAAFGQAGPPHGSSFFGSPAGRYCDGRLVIDFIAESLGLPYLSAFLDSVGSNFSHGANFATAGSPIRALNSTLRQSGFSPFSLDVQFVQFYNFHNRSQTVRSRGGVYKTMLPESDSFSKALYTFDIGQNDLTAGYFANKTVEQVETEVPEIISQFMNAIKNIYGQGGRYFWIHNTGPIGCLAYVIERFPNKASDFDSHGCVSPLNHLAQQFNHALKQAVIELRSSLSEAAITYVDVYSLKHELFVHAQGHGFKGSLVSCCGHGGKYNYNKGIGCGMKKIVKGKEVYIGKPCDEPDKAVVWDGVHFTQAANKFIFDKIAPGLSKACKRQ
Protein: Sodium/hydrogen exchanger (B7YZY3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSIRTEQDYDSATPALAQQMNLARRACWRIKSYSSESLFKTYASVITDTSANEIDAEAPPPPRDKTKTRIEPQIAPAKRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNAEECQQNPNEINVVGPSDDWDDGLTFTAKSSLAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKRQGDECTDAVQQNEFPAWASNKEYLAYNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSSQPPNAPSTSIHNPRLDKRSQSISSSSLGAGAHQLGPEGHSGPFPVTASHRRNVRRGSMLELSGDTIPEESSYQHGHSKSLCEPADSDEWEGAPLSAAGGANSELLMRMSGREPLLPRPSNTPRAQIRRMNAGAVGGAGVSQAGRKNQVTKALLDYEDSETDSDENDDDEDEDFDSYDDENIVVTTFTTPATGRRPGSSPGSGSEANTATTTTTSIRLTRNNDESII
Protein: Monogalactosyldiacylglycerol synthase 2, chloroplastic (AtMGD2) (EC 2.4.1.46) (MGDG synthase type B) (O82730)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of monogalactosyldiacylglycerol, the major structural component of photosynthetic membranes and in the chloroplast envelope biogenesis. Can use both prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2-diacylglycerol species, but operates with some preference for the eukaryotic one. Plays a minor role in galactolipid synthesis in chloroplasts. Is required for membrane lipid remodeling in phosphate-starved roots. Acts as the minor factor involved in digalactosyldiacylglycerol (DGDG) biosynthesis in phosphate-starved roots. Does not seem to be required for plant growth under nutrient-sufficient conditions. Required for membrane lipid remodeling in plants grown in acidic conditions.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000305|PubMed:11553816}.
Interaction partners:
- Digalactosyldiacylglycerol synthase 1, chloroplastic
- Sulfoquinovosyl transferase SQD2
- Digalactosyldiacylglycerol synthase 2, chloroplastic
- Galactolipid galactosyltransferase SFR2, chloroplastic
- Phosphatidate phosphatase PAH1
- Phosphatidate phosphatase PAH2
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
- Triacylglycerol lipase SDP1
- Diacylglycerol O-acyltransferase 3
- Diacylglycerol O-acyltransferase 1
Sequence:
MATTVMALAEKVLERVYGTSKSAVSVTSGDGEKTHRHTHHHIHRIKSYDDIDEDESSLELIQIGAERTKNVLILMSDTGGGHRASAEAIRDAFKIEFGDKYRVIVKDVWKEYTGWPLNDMERSYKFMVKHVQLWKVAFHSTSPKWIHSCYLAAIAAYYAKEVEAGLMEYKPEIIISVHPLMQHIPLWVLKWQELQKRVLFVTVITDLNTCHPTWFHPGVNRCYCPSQEVAKRALFDGLDESQVRVFGLPVRPSFARAVLVKDDLRKELEMDQDLRAVLLMGGGEGMGPVKETAKALEEFLYDKENRKPIGQMVVICGRNKKLASALEAIDWKIPVKVRGFETQMEKWMGACDCIITKAGPGTIAESLIRSLPIILNDYIPGQEKGNVPYVVENGAGVFTRSPKETARIVGEWFSTKTDELEQTSDNARKLAQPEAVFDIVKDIDELSEQRGPLASVSYNLTSSFASLV
Protein: Neuronal pentraxin 1.4 kb variant (Q6TLW0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKQELPARGNLSSAPAPAMPTALHSKMDELECQLLAKVLALEKERAALSHGSHQQRQEVEKELNALQGRVAELEHGSSAYSPPDAFKVSIPIRNNYMYARVRKALPELYAFTACMCVRSRSGGSGQGTPFSYSVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICISWTTRDGLWSAYQDGELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGMANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA
Protein: Kinesin-like protein KIN-7D, chloroplastic (Q6YZ52)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable minus end-directed motor protein with a microtubule-enhanced ATPase activity. Binds ATP/ADP in vitro. Retains total enzymatic activity even after the removal of the ADP bound in the active site.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Kinesin-like protein KIN-10A
- Kinesin-like protein KIN-UA
- Kinesin-like protein KIN-1
- Kinesin-like protein KIN-UB
- Kinesin-like protein KIN-14I
- Kinesin-like protein KIN-14B
- Kinesin-like protein KIN-14G
- Kinesin-like protein KIN-14J
- Kinesin-like protein KIN-14N
- Kinesin-like protein KIN-14H
Sequence:
MATRPASRQRRASSAAAAVAVVRSSPQPQQQQQQQLPIPQSGSPTSTTTTTTSSSRLTPELSLDGPASPLFAGLDEDPAPKENVTVTVRFRPLSPREIRQGEEVAWYADGDTVVRSEQNPSVAYAYDRVFAPTTTTRQVYDVAAQHVVSGAMEGVNGTIFAYGVTSSGKTHTMHGDQRSPGIIPLAVKDAFSIIQETPNREFLLRVSYLEIYNEVVNDLLNPAGQNLRIREDPQGTFVEGIKEEVVLSPAHALSLIAAGEEHRHVGSTNFNLLSSRSHTIFTLTVESSPCGESNEGEAVTFSQLNLIDLAGSESSRAETTGVRRKEGSYINKSLLTLGTVISKLTDGKATHIPFRDSKLTRLLQSSLSGQGRVSLICTVTPASSNSEETHNTLKFAHRAKRIEVQASQNKIIDEKSLIKKYQNEIRRLKEELEQLKMGIITGTPVKDAGEDNIILWKQKLEDGNVKLQSRLEQEEEAKAALLARIQRLTKLILVSTKATQTSRFSPHPGPRRRHSFGEEELAYLPYKRRDIVLDNESNELLSPVEGLGMTLEDSKEEKKNRKGILNWFKLRKREGGASILTSSEGDKSSLTKSTAPSTPIGESVNFPSEPRISNSLVGESASVDLFSIGHGEFATDSLHGEETPLASRKTIDHVDLLREQLKILSGEVALHTSVLKRLTEEAGRSPNNEKIQMEMKKVNDEIKGKKHQIASLERQIPHSISNNQGMADKLELTPSYAELLEQLNEKSFDLEVKAADNRVIQDQLNEKTTECMELQEEVAHLKEQLYQTLQAKDSLSNSIMMQKNAGINHETDNHADQELSVPREVPGETSPKEPQSVEIDELKQKVCELIEVKAQLETRNQKLLEESTYAKGLASAAGVELKALSEEVTKLMNQNEKLASELASVRSPTPRRANSGLRGTRRDSISRRHEPAPRRDNNAGYEREKALEAVLMEKEQKEAELQRRIEESKQKEAFLESELANMWVLVAKLKKSQGHDLEDFDTKYIGS
Protein: Ankyrin repeat and SOCS box protein 16 (ASB-16) (Q96NS5)
Organism: Homo sapiens (Human)
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
Sequence:
MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
Protein: B-cell lymphoma 3 protein homolog (BCL-3) (Q9Z2F6)
Organism: Mus musculus (Mouse)
Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16713561}. Cytoplasm {ECO:0000269|PubMed:16713561}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16713561}. Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- Nuclear factor NF-kappa-B p100 subunit
- Ubiquitin carboxyl-terminal hydrolase CYLD
- Pirin
- Transcription factor RelB
- Proto-oncogene c-Rel
- Transcription factor p65
- Histone deacetylase 1
- Tumor necrosis factor receptor superfamily member 5
- Suppressor of cytokine signaling 3
Sequence:
MPRCPAGAMDEGPVDLRTRPKGTPGAALPLRKRPLRPASPEPATTRSPAGPLDALRSGCDVPVVPGPPHCVARPEALYYQGPLMPIYSTPTMAPHFPLLNLPTHPYSMICPMEHPLSADIAMATRVDEDGDTPLHIAVVQNNIAAVYRILSLFKLGSREVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQALLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNMVQLLLLHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKNCHNDTPLMVARSRRVIDILRGKASRAASGSQPEPSPDQSATNSPESSSRLSSNGLQSSPSSSPSLSPPKDAPGFPATPQNFFLPTTSTPAFLPFPGVLRGPGRPVPPSPAPGSS
Protein: Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (A0A8I5ZYB4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDCLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVANMHNGMNQQAYAYPATAAAAPMIGYPMPTGYSQ
Protein: Calcium channel, voltage-dependent, T type, alpha 1G subunit (Q5SUG1)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAVGVRAGLLSSPVARGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRWLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPEMLKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHEMPDSDSEAVYEFTQDAQHSDLRDPHRRRRPSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHSELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGKSASGRLARTLRADDPPLDGDDGDDEGNLSKGERLRAWVRARLPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGPRPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTDLDP
Protein: Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) (O62849)
Organism: Ovis aries (Sheep)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13516}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Elongation of very long chain fatty acids protein 6
- Fatty acid synthase
- Enoyl reductase
- Very-long-chain
- Hydroxysteroid 17-beta dehydrogenase 12
- 17beta-estradiol 17-dehydrogenase
- Stearoyl-CoA desaturase 5
- Very-long-chain
- Very-long-chain
- Very-long-chain
Sequence:
MPAHLLQEEISSSYTTTTTITAPPSRVLQNGGGKLEKTPLYLEEDIRPEMRDDIYDPNYQDKEGPKPKLEYVWRNIILMGLLHLGALYGITLIPTCKIYTFLWVLFYYVISALGITAGVHRLWSHRTYKARLPLRVFLIIANTMAFQNDVFEWSRDHRAHHKFSETDADPHNSRRGFFFSHVGWLLVRKHPAVREKGATLDLSDLRAEKLVMFQRRYYKPGVLLLCFILPTLVPWYLWGESFQNSLFFATFLRYAVVLNATWLVNSAAHMYGYRPYDKTINPRENILVSLGAVGEGFHNYHHTFPYDYSASEYRWHINFTTFFIDCMAAIGLAYDRKKVSKAAVLGRMKRTGEESYKSG
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (F6VDE0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTMGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNRGKAKPVVSDFDSDEEQDEREQSEGSGTDDE
Protein: Gp150 protein (Gp150, isoform A) (Gp150, isoform B) (Gp150, isoform C) (Gp150, isoform F) (RE46351p) (Q24007)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSRQSTCRLVLLLAFTLALIHASHSNTVGPKIHFIHDDLTENELNSGEEVSPTESLPKISTPKVKDLPVETTTRSPTKKTTSSGTEKSLSEEAWNDLMEAAKHSQALADDPHFNKMLNTTVAAGEKNSTDTDDSEYYDYDDDYNYFDEETVTISPSPKKAKSNPKLQPIVDATITKSKSKSNDQKTKESANDIDSDSQYDYDEGLDDDDDEDDAADDLLTDDEQVVFSEDVPCPRFCQCARNVNSYLVATCSRLDMGIQKFGSDITDLVVTNVGPKYPILMGPNFFQNLGLKNVASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEFISYVTLQMQMTPKRLPVLANLEDDATIVQLETLAQAGWSSLAHEVCKHAEGSDLLDEKKADSAEAKLEKRLKESVKKLNEDEAKLLSVLDKSVLDKSRLSSMQKIMKGSVNTETAKPEEDADEENLNNGGEDKEDDSSDYDSEEDDDDDDEDDDDDNNDDDRFEEAKKNAKAKADANKAFDTFVNKELKPVLKTDGIQAEEVDMSQETRDKFLLEKLGFDSESEESDEYTEKMIFHGELSYDLVVPLIVVSFCLLMIVLSIARVIYVVLRKRGERYRMALLASKNSFVYQKLSEDIVKPTSKEQKEPKHLKQPKVHRYAPINQV
Protein: Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2) (O43868)
Organism: Homo sapiens (Human)
Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
Subcellular location: Membrane {ECO:0000305|PubMed:9435697}; Multi-pass membrane protein {ECO:0000255}. Apicolateral cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells in testis. {ECO:0000269|PubMed:35307651}.
Interaction partners:
- Equilibrative nucleoside transporter 2
- Equilibrative nucleoside transporter 1
- Solute carrier family 22 member 1
- Probable proton-coupled zinc antiporter SLC30A4
- Glycine amidinotransferase, mitochondrial
- Dual oxidase 1
- Equilibrative nucleoside transporter 3
- Dual oxidase 2
- Equilibrative nucleoside transporter 4
Sequence:
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA