wanglab/gogpt-training-data huggingface dataset:
Protein: Enhanced level of genomic instability 1 (Q86BP6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has an important role in DNA replication and in maintaining genome integrity during replication stress (By similarity). Promotes PCNA deubiquitination (By similarity). As component of the Elg1 RFC-like complex, regulates the functions of the DNA polymerase processivity factor PCNA by unloading it from DNA after replication during the S phase of the cell cycle. The PCNA-unloading might be regulated via interaction with the Enok acetyltransferase complex. Might have a role in restarting of stalled/regressed replication forks during replication stress (By similarity). In the ovaries, has a role in nurse cell endoreplication.
Subcellular location: Nucleus {ECO:0000269|PubMed:27198229}.
Interaction partners:
- Replication factor C subunit 3
- Replication factor C subunit 2
- Replication factor C subunit 2
- Activator 1 subunit 5
- Chromosome transmission fidelity 4
- ATP-dependent DNA helicase Q4
- Bromodomain-containing protein homolog
- Rad17
- Structural maintenance of chromosomes protein
- Exonuclease 1
Sequence:
MTDVNCLTSEHIAPTTTTASPPGTPSKNAATDPVEPTSPFVLRAPPSAKSKLILQNMEEVLNSVKQKHREKHKRKREEKRRAALMEDQKSTTEEVKANAKEKPQPLREKSSQENGLKNGRRRSSPLKSSTPVADNQSIMKHFAKAGKPENVGVSPVSTAKPKPTTNVFEFMMNARNRSLGVNEGGAESPADQEIGSEAATPTTKRKLLLQEWNERKGGAKRRLADEARGEFIELQMEQRAKRLRKMLTKTDAKEVTAPSSAPTDPTVKRLRGRPRSRRISSMDAQNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRDSLLGYFPKVESPKELAEKVIIAIETPPMETPKRRTLRRKSQQETPIVAESTPSSRPRRSCVGKARYDYDLETSPGKQQKAKPQKADESVEIIDLDNSNPAATPKKLAPLFVRQLPKPSPDPSVLKARQAFLQSGVPDKIRQEQIRQKNFDQMYEDSYEVFPRLAHIGCESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSITSCLPADFTSSKTLNKFNYATLPQLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQDTQQMGESLVVTRRTRRSMEQNMAQNEEEAKPPPSAPNGELLFTEKYKPLLFEQVLVNLTPVQELREFLSSWSGNGGSNRNSQGMDDTFDMSNDSASMGSSSNTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDGKAGGGSSQQLLQKLQKSGLKAKAAAVEPPSEVRKSLILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDPNCAHLQRLMQQNIIHFQAPNALNISRFLAVLSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRDRTGGGIKSPTKTSNSRLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLPDLMASSAMLKEQQAAGGGSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSLATLASFYDNISVASLMDSDCSDRLQWHLSEEIGHLLVEQALQTGLATKECPYNLFDKPVQRFSICQHLGNGVLRSDSAKSLDFEPALRSICRSEKERAGLERKSSRFYHYLRNHTVNVTSFTTDYFDTACSTFQSAAPSSEPTMEAEPKD
Protein: Polyunsaturated fatty acid lipoxygenase ALOX8 (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (Arachidonate 8S-lipoxygenase) (8-LOX) (8S-LOX) (EC 1.13.11.-) (Linoleate 9S-lipoxygenase ALOX8) (EC 1.13.11.58) (O35936)
Organism: Mus musculus (Mouse)
Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Catalyzes the peroxidation of arachidonate and linoleate into (8S)-HPETE and (9S)-HPODE respectively. In addition to generate (8S)-HPETE from free arachidonic acid (AA), may produce other HETE isomers from phospholipid-esterified polyunsaturated fatty acids and minor products derived from (8S)-HPETE itself that may include leukotriene A4 and 8,15-diHPETE. With free arachidonate as substrate, has no detectable 15S-lipoxygenase activity and only displays a 8S-lipoxygenase activity. However may have a 15S-lipoxygenase activity with (8S)-HPETE to produce (8S,15S)-diHPETE and when oxidizes directly arachidonic acid esterified to membrane-bound phospholipids to produce a phospholipid-esterified 15-HpETE. May also catalyze (15S)-HPETE peroxidation to produce 8,15-diHPETE. May play a role in keratinocyte differentiation through activation of the peroxisome proliferator activated receptor signaling pathway.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15296}. Membrane {ECO:0000250|UniProtKB:O15296}; Peripheral membrane protein {ECO:0000250|UniProtKB:O15296}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. {ECO:0000250|UniProtKB:O15296}.
Interaction partners:
- Prostaglandin G/H synthase 1
- Prostaglandin G/H synthase 2
- Cytosolic phospholipase A2
- Group XIIB secretory phospholipase A2-like protein
- Cytochrome P450 4A10
- Glutathione peroxidase 3
- Cytosolic phospholipase A2 epsilon
- Epididymal secretory glutathione peroxidase
- Cytosolic phospholipase A2 gamma
- Cytosolic phospholipase A2 zeta
Sequence:
MAKCRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKEFSAGAEEDFEVTLPQDVGTVLMLRVHKAPPEVSLPLMSFRSDAWFCRWFELEWLPGAALHFPCYQWLEGAGELVLREGAAKVSWQDHHPTLQDQRQKELESRQKMYSWKTYIEGWPRCLDHETVKDLDLNIKYSAMKNAKLFFKAHSAYTELKVKGLLDRTGLWRSLREMRRLFNFRKTPAAEYVFAHWQEDAFFASQFLNGINPVLIRRCHSLPNNFPVTDEMVAPVLGPGTSLQAELEKGSLFLVDHGILSGVHTNILNGKPQFSAAPMTLLHQSSGSGPLLPIAIQLKQTPGPDNPIFLPSDDTWDWLLAKTWVRNSEFYIHEAVTHLLHAHLIPEVFALATLRQLPRCHPLFKLLIPHIRYTLHINTLARELLVAPGKLIDKSTGLGTGGFSDLIKRNMEQLNYSVLCLPEDIRARGVEDIPGYYYRDDGMQIWGAIKSFVSEIVSIYYPSDTSVQDDQELQAWVREIFSEGFLGRESSGMPSLLDTREALVQYITMVIFTCSAKHAAVSSGQFDSCVWMPNLPPTMQLPPPTSKGQARPESFIATLPAVNSSSYHIIALWLLSAEPGDQRPLGHYPDEHFTEDAPRRSVAAFQRKLIQISKGIRERNRGLALPYTYLDPPLIENSVSI
Protein: Ribonuclease P protein subunit drpp30 (EC 3.1.26.5) (RNaseP protein 1) (Q3ZE13)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RNase P protein subunit
- RNase P protein subunit
- Probable ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p29
- RNase P protein subunit
- NHP2-like protein 1 homolog
- RNase P protein subunit
- RNase P protein subunit
- H/ACA ribonucleoprotein complex subunit 2
- Kri1-like C-terminal domain-containing protein
Sequence:
MVYYDLNIDSSLPEPKIKSMLSLHTKYGYDSVAITHTVEGKIGYKDVCKIKKIQIEDDSEKSTSSGWMKMGDSNKTIKQYTRLQVICKTMAEFQMITANNPVVQSYDIISVVPYDVSVFNAACNSNEIDIITIDTFSKFIIKPERVRQCIAKGIFIEILYGNLFGIDADRIAFFQIASSLVRSSFGKNIILSSSGKSSTTLRSPYDLSNLGHLFGLTFDQAKAAVSKHPHTAVLHAITRRTKGIATVTDPNLLKDLELWKLERKEDTQPTNNNIPHEKHINKESTGKETIPKPTTTTTTTTTTTTTAKTKTPTPTPTTEKTPSIPTQPPQKPTAKSNKKTTTNTTSTAQKQGKMDIDIDNNKRKRE
Protein: MPN domain-containing protein (Q93568)
Organism: Caenorhabditis elegans
Interaction partners:
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 7 homolog
- ER membrane protein complex subunit 6
- Membrane magnesium transporter
- ER membrane protein complex subunit 10
- DNA polymerase delta catalytic subunit
Sequence:
MKHQVETQALPYSTIILHCLKYPAKGVFGLLIGNKKGDKVTVTSCVPLCHESTPLAPPLELATALVHGKFGASLVGVYFSNATPSDTSLNVYATRLADRISSVTSSAAILVQVMNERLVSDCEQDRLVAYEKDGDSWKETKTIFQGSNFLRGLQAVIQKKLYRELSDFENHLDNPEFDFYNTNLSNKLVQVAEFRA
Protein: Galectin-related protein (Galectin-like protein) (Lectin galactoside-binding-like protein) (Q3ZCW2)
Organism: Homo sapiens (Human)
Function: Does not bind lactose, and may not bind carbohydrates.
Interaction partners:
Sequence:
MAGSVADSDAVVKLDDGHLNNSLSSPVQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIVDLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG
Protein: Pheromone M-factor receptor (P31397)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Pheromone P-factor receptor
- Pro-P-factor
- E3 ubiquitin-protein ligase pub3
- E3 ubiquitin-protein ligase pub1
- E3 ubiquitin-protein ligase pub2
- Casein kinase I homolog 2
- Casein kinase I homolog 1
- Casein kinase I homolog 3
- Protein kinase byr1
- Guanine nucleotide-binding protein alpha-1 subunit
Sequence:
MLPIGIFYQFYAYFALVLSIPILYMQLRARNIPCLLLLFWLTLTTLIYVVESAIWSNPYAETIRWMGYGLCDITSRIVTCSSIGIPASAFTLVLYLDTVIRRDHPLKRYENWIWHVCLSILLPLIIMAMMVPLESNRYVVICMNGCYSSFYQTWYTLLFFYIPPCLLSFGGLFFVSRIVVLYWRRQRELQQFFQRDSQLTSKRFLRLLCLAAVFFLGYFPLTIFMVVANGKLQQFLPFNHELVEAWHQESITYYPTTKVGLNDWVPPTVLYLMSLFFSTSGGWTEKVALILWSLLVWLPFTKNTALGRHAQFKLDCCKSIESTMAGKTLDSTDFKEKCLVLERQWSKSSIPSDNSSELQDAAKYV
Protein: Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt) (Q9VZD5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P82932}.
Interaction partners:
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein bS16m
- 40S ribosomal protein S15
- Small ribosomal subunit protein uS7m
- DSec61alpha
- Elongation factor Ts, mitochondrial
- Small ribosomal subunit protein uS5m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS3
Sequence:
MPSYELALVLRQLPRPELISVIRRTAESILDKGGIIRKLENLGSRALPHKVSEHGVVHREGTHFTIAFDTAPTKIADLKEEFGRDIDIIRRYIFKVEEPEQKPCTLHEEMLPPAYRKDVQEIIAAAQKKQKKKFNYNSGLDYYPFQK
Protein: SAV-6107-like HEPN domain-containing protein (Q8NNM4)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Hypothetical membrane protein
- Uncharacterized ACR
- DUF2188 domain-containing protein
Sequence:
MGDVISATTRFERVGGKRAQFFSKAHILLEQAHTYRGEGDLLLALEMSYQSALRTAGAVVAGSDVAARKRKPKSAWDQLQLVGDEAAEWAAELSQFSTIRSRASSGLDITLSAADLDRFMARVALFLEEAQHGFSPSVDAA
Protein: Early endosome antigen 1 (A0A8I6AIN6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPLCMKRCVTAIDLSEHYQQVHTELETRGQELLSDSNVTGFICPQCMKSLGSADELFKHYQAVHDAGNDSGHGGEASLALTRDDIALLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKSDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEEKGLRAAAEQKATHLTEELSKQTTVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSEHANSEATINQLRSELAKGPQEVAVYVQEIQKLKGSVNELTQKSQTLMEKLQKKDLDYTHLEEKHNEEALSRKNTQAALHQRDLDCQQLQARLTASEGSLQRIQGELREKGEAAQKLKEELREVETKHQHLKVEFKQLQQQREEKEQHGLQLQGEVSQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLEKSKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHALQQQLTQLMEKLKNQSESHKQAEENLHDQVQEQKAHLRAAQDRVLSLETSVSELSSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKVSAQLDQVTAKFQEKQEHCTQLESHLKDYKEKHLSLEQKAEDLEGQIKKLEANNLEVKASREQAVQSLQQQRQLSTDLELRNAELRKQLQEQKEVVSHTKLDLQNKSEALENIKQTLTKKEEEKVVLKQEFEKLSQDSEAQHKELSDRMQAAITELMVMTAQKDALLAELSTTKGKLSKVSDSLQTSRSEFEKESQKGKAAVLDLEKACKELKHQLQQQTESALKEQSELKKSLEKERETSQQLMIELNSVKGEVTQAQNTLKQKEKEEQQLQGNINQLKQATEQKKKQMEALQGELKNVTSQKAQLESKLQQQAAQAAQELAVEKGKLSALQSTYDKCQADLQQLQSDLYGKESELLATRQDLKCVEEKLALAQEDLISNRNQIGNQNKSIQELQAAKAALEQDLAKKEEVLKEQSKALQDAQREKSVKEKELVTEKSKLAEMEEIKCRQEKEIAKLKEELKSHKQESIKEVTNLKDAKQLLIQQKLELQGKVDSLKAALEQEKERQQLMREQMRKEEEKRKEEFSEKEAKLHSEIKEKEAGVKKHEENEAKLTMQVTTLNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDLQG
Protein: Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) (P14540)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Phosphoglycerate kinase
- Triosephosphate isomerase
- Phosphoglycerate mutase 1
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Glyceraldehyde-3-phosphate dehydrogenase 3
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase subunit alpha
- Enolase 2
- Enolase 1
Sequence:
MGVEQILKRKTGVIVGEDVHNLFTYAKEHKFAIPAINVTSSSTAVAALEAARDSKSPIILQTSNGGAAYFAGKGISNEGQNASIKGAIAAAHYIRSIAPAYGIPVVLHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEETDEENISTCVKYFKRMAAMDQWLEMEIGITGGEEDGVNNENADKEDLYTKPEQVYNVYKALHPISPNFSIAAAFGNCHGLYAGDIALRPEILAEHQKYTREQVGCKEEKPLFLVFHGGSGSTVQEFHTGIDNGVVKVNLDTDCQYAYLTGIRDYVLNKKDYIMSPVGNPEGPEKPNKKFFDPRVWVREGEKTMGAKITKSLETFRTTNTL
Protein: GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (K7EL34)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367138}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367138}.
Interaction partners:
Sequence:
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPL
Protein: TAR DNA-binding protein 43 (TDP-43) (Q921F2)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13148}. Cytoplasm {ECO:0000269|PubMed:30464263}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q13148}. Mitochondrion {ECO:0000250|UniProtKB:Q13148}. Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. A small subset localizes in mitochondria. {ECO:0000250|UniProtKB:Q13148}.
Interaction partners:
- RNA-binding protein FUS
- Matrin-3
- Ribonuclease 3
- Superoxide dismutase
- E3 ubiquitin-protein ligase parkin
- Alpha-synuclein
- Ataxin-2
- Protein deacetylase HDAC6
- Coiled-coil-helix-coiled-coil-helix domain containing 10
- SUMO-conjugating enzyme UBC9
Sequence:
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
Protein: RNA-binding protein Unr (Protein upstream of N-ras homolog) (B7Z0E2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16452509}.
Interaction partners:
- Protein sex-lethal
- Polyadenylate-binding protein
- E3 ubiquitin-protein ligase msl-2
- Raf homolog serine/threonine-protein kinase Raf
- Maternal protein pumilio
- Ral guanine nucleotide dissociation stimulator-like, isoform E
- Heterogeneous nuclear ribonucleoprotein 27C
- LD37574p
- Trailer hitch, isoform H
- Eukaryotic translation initiation factor 4E1
Sequence:
MNTQSKVYRTGEEIYDNLPCDSYFNMNAIRNLGIPTTFPTIGTFTLDSTTLGLQPQGQGPSPQQQQHQQQQQQQQQQHQQNMHHHQHQQQHMQQQQQQQQHQQQHQQQQHQQQQQHQQQQQQQQQHPTIGMFDANEVNDVIQNPPQIGVFQSNSVLTNGAGSGSSIFGSQSSNSSAAAADPSQTTRETGIIEKLLHSYGFIQCCERQARLFFHFSQFSGNIDHLKIGDPVEFEMTYDRRTGKPIASQVSKIAPEVVLSEERVTGTVTTELRTDSANNVLNSSETTGRISYENRGECFFLPYTKDDVEGNVNLRAGDKVSFQIATNQRGNLGACHIRLENPAQPVKYRGVVCSMKESFGFIERADVVKEIFFHFSEAEGNVELRPGDDVEFTIQTRSSASVPPQGREFACNITRLAPGSVIFEDVDSTVYKGQVLKSLDRNNPVRQNNDPLPGRIRYRALDYSEVEVPFGDKDQKGDFTLRHGDWVQFLLATDRRDQLQRATSIALLDETFKVSGEKREQGTIASLKEGFGFLRCVERQARLFFHFTEVLDTSREIDINDEVEFTVIQEPGLAYNNSRLQAIRIKHLPPNSVQFETLVASNIEGCVTREAPKSPIKSQDRVEGGVITYEHADVKKTIMYFLKDCEKPPRIGERVRFDIYMVKRNKECIAVNVQQVSLHQQQQQQQQQLHLNQSNAGANINQNDQLGGLSNGISSSSSNASLQNGYVMHGSPGGSTSSVGSNNPVHLDEFKMENNNHAGSDAGQVYRGFIAVMKENFGFIETLSHDEEVFFHFSNYMGNPNWLELGQEVEYTLARNGNTSVSGNCLPAENVRMLPKNSIPQPAVLETTHNGVVARPLRCINPDQQEYAGLIEILDELRTTVISQHEFGITSLVNKRDLLQKGDLVSFRIDESGRAACVNAVRQKKRATVDSIKGQFGFLNFEVEDGKKLFFHMSEVQGNTVALHPGDTVEFSVVTNQRNGKSSACNVLKINDRPDRLISRLKLNGDDTVPRLILIRAPKGPQGKGFSVLARHPRIPGNLVE
Protein: Beta-conglycinin beta subunit 2 (CG-beta-2) (allergen Gly m 5) (F7J077)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Seed storage protein. Accumulates during seed development and is hydrolyzed after germination to provide a carbon and nitrogen source for the developing seedling.
Subcellular location: Vacuole, aleurone grain {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:15447650}. Protein storage vacuole {ECO:0000269|PubMed:15447650, ECO:0000269|Ref.5}. Note=Localizes in protein storage vacuoles in cotyledons of developing and mature beans (PubMed:15447650, Ref.5). Synthesized and assembled into trimers in the endoplasmic reticulum, and transported to the protein storage vacuoles by the dense vesicles (PubMed:15447650). {ECO:0000269|PubMed:15447650, ECO:0000269|Ref.5}.
Interaction partners:
- Glycinin G4
- Glycinin G2
- Glycinin G1
- Protein EARLY FLOWERING 4 domain-containing protein
Sequence:
MMRVRFPLLVLLGTVFLASVCVSLKVREDENNPFYLRSSNSFQTLFENQNGRIRLLQRFNKRSPQLENLRDYRIVQFQSKPNTILLPHHADADFLLFVLSGRAILTLVNNDDRDSYNLHPGDAQRIPAGTTYYLVNPHDHQNLKIIKLAIPVNKPGRYDDFFLSSTQAQQSYLQGFSHNILETSFHSEFEEINRVLLGEEEEQRQQEGVIVELSKEQIRQLSRRAKSSSRKTISSEDEPFNLRSRNPIYSNNFGKFFEITPEKNPQLRDLDIFLSSVDINEGALLLPHFNSKAIVILVINEGDANIELVGIKEQQQKQKQEEEPLEVQRYRAELSEDDVFVIPAAYPFVVNATSNLNFLAFGINAENNQRNFLAGEKDNVVRQIERQVQELAFPGSAQDVERLLKKQRESYFVDAQPQQKEEGSKGRKGPFPSILGALY
Protein: Bigmax (GM14426p) (Q9VB47)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- LD38259p
Sequence:
MSDNNNALATKEDVFGMEHDQDHTSKHYSRCSSAGSTHTPNSSAHNSDDDDDSGDARHSAAANSTLSYKERRREAHTQAEQKRRDAIKKGYDSLQELVPRCQPNDSSGYKLSKALILQKSIEYIGYLNQQKLKQEDEGSALQKEVTALRIIKNGYENMLQHQQANPGPEEARLTDEAKFQVFQAIMEEMFETFQHIPMENFKQLTTGIIPWLEEHCKPHILRNILSRTLQQMAQEAMEKQELQAMEQESSEGFS
Protein: E2F transcription factor-like E2FE (DP-E2F-like protein 1) (E2F-like repressor E2L3) (Q8LSZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication.
Subcellular location: Nucleus {ECO:0000269|PubMed:11867638}.
Interaction partners:
- Protein FIZZY-RELATED 1
- Transcription factor-like protein DPA
- Transcription factor-like protein DPB
- Retinoblastoma-related protein 1
- Protein POLYCHOME
- Protein FIZZY-RELATED 2
- Protein FIZZY-RELATED 3
- GATA transcription factor 27
- Cyclin-B1-1
Sequence:
MSDLSPERFKLAVTSPSSIPESSSALQLHHSYSRKQKSLGLLCTNFLALYNREGIEMVGLDDAASKLGVERRRIYDIVNVLESVGVLTRRAKNQYTWKGFSAIPGALKELQEEGVKDTFHRFYVNENVKGSDDEDDDEESSQPHSSSQTDSSKPGSLPQSSDPSKIDNRREKSLGLLTQNFIKLFICSEAIRIISLDDAAKLLLGDAHNTSIMRTKVRRLYDIANVLSSMNLIEKTHTLDSRKPAFKWLGYNGEPTFTLSSDLLQLESRKRAFGTDITNVNVKRSKSSSSSQENATERRLKMKKHSTPESSYNKSFDVHESRHGSRGGYHFGPFAPGTGTYPTAGLEDNSRRAFDVENLDSDYRPSYQNQVLKDLFSHYMDAWKTWFSEVTQENPLPNTSQHR
Protein: Large ribosomal subunit protein mL46 (54S ribosomal protein L17, mitochondrial) (O94398)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein mL43
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein uL22m
- Small ribosomal subunit protein uS11m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein mL44
Sequence:
MYLKRNIINMQRSFSRQFHISVRNSIQSSKPLSNSTPLKGCSVGTILIRSPILTRQPSEFEKSIYKYNAELWNELSDPLPAEFYFKKGSVGEKDWQERQKTLKGKESPFETIFGKERKEMESNKLLDSATHLQSRVTEADTKNDERSTLRSLDKSLYLLVKKSKSSGWQFPNTPVTSSEKALHLLCQDLLKNILDENSLTWLVARHPLALLKTEQEKTFLLRARLLNGLDVPNLQNVYDWVWCTYDELKNKLSPSSWDSVKNILSDRL
Protein: K(+)/H(+) antiporter 1 (P40309)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Potassium-proton antiport.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Endosomal/prevacuolar sodium/hydrogen exchanger
- Na
- Sodium/potassium exporting P-type ATPase 1
- High-affinity potassium transport protein
- Low affinity vacuolar monovalent cation/H
- Outward-rectifier potassium channel TOK1 channel YORK)
- Low-affinity potassium transport protein
- Mitochondrial distribution and morphology protein 38
Sequence:
MANTVGGILSGVNPFHYNSSSPLTLFLFQACLILLVCNLIHIPFSMMRQPKVISEVISGVILGPTIFGQIPNYTNTIFPTSSIPGLNLVANLGIILFMFFLGLEVDIAFIKKHLKKALVIGIVTLAVPFGFGCLLAIPLFHTYANKTEGERHIKFSVFMVFIAVSISVTAFPVLCRILNELRLIKDRAGIVVLAAGIINDIMGWILLALSIILSSAEGSPVNTVYILLITFAWFLIYFFPLKYLLRWVLIRTHELDRSKPSPLATMCILFIMFISAYFTDIIGVHPIFGAFIAGLVVPRDDHYVVKLTERMEDIPNIVFIPIYFAVAGLNVDLTLLNEGRDWGYVFATIGIAIFTKIISGTLTAKLTGLFWREATAAGVLMSCKGIVEIVVLTVGLNAGIISRKIFGMFVLMALVSTFVTTPLTQLVYPDSYRDGVRKSLSTPAEDDGAADGLDSEGVDKTEINTQLNSLADVSKYRIGELTTVINTTEAISPSLKLLNYLSLGVSPKPKNNKHKNETSLSRMTTATDSTLKSNTFKIKKMVHIWSKSVDDVDTNLSVIDEKLTPFEGVGALRAIHLRLLTERTTDLLQSSSLYNDDPHFTANTDSLLQIFDIFSNLSKIPFSSEVIFSTMREKAANIATMKMDSTDLILLPLKGASYEYRGSPVFIDEKYANFDHIYSHLLGLNELSSTFFKSIFQSLKANFAVQISNTYGRLNADRFKRKRFNLLLPKPYLTQSDYLGLYLLLLICYRDGYNNDNASCSIFINSKNIDFAKDLSTAFAEHDWLNESTIKIVDIPFETKVPEEAIEKPSFIETVLDVGLSDTALADIEETTFIIGEDLPDESEPFSEEVRTVIFEGSNRRFDTLIVHHFSSE
Protein: Vacuolar protein sorting-associated protein 38 (Q05919)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11157979}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:11157979, ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Serine/threonine-protein kinase VPS15
- Phosphatidylinositol 3-kinase VPS34
- Vacuolar protein sorting-associated protein 30
- Autophagy-related protein 14
- Autophagy-related protein 18
- PtdIns3K complex I subunit atg38
- 1-phosphatidylinositol 3-phosphate 5-kinase FAB1
- Polyphosphoinositide phosphatase
- Vacuolar segregation protein 7
- Vacuole morphology and inheritance protein 14
Sequence:
MKRFLLSRRQRHLRMICFHNISLFRANGDSKLIKEYGDGFIPCFFILESIRGELLYVSEVQSGSLRKLSFQELPKLTGASTMIVLKLVGLVPSDILCTISSDKNGIIDDKWCVLCTYTIDLNKLQPINEDTVLITGTNAPVLDLIDGSYTLAAEKIKPLKGLVSSHKRNISQVKIKFSLAYSSLLKLNKLLEYSSQVHEEINEISSKIEDDFLSLKNQNHWYMRTVQKSIETLEKEVLQRKKSKKNIEMAQLESNDTINHSKTELSLMSQDESINDDYGSIYSRFVQIKDRLDQLRFKKLYQLIGIFHSTDLFNSDRGYIYFEKPSSVNDVINRLKLKPLNIEILLRQAGESTKHREYVNSQLGYYLLFLHLTAIQIFKAPLPYRLMYYGSTSVIDSQYPLYFTDQMISKHQAKLIKAIHYFNADILQFKQILENYRPT