wanglab/gogpt-training-data huggingface dataset:
Protein: SID1 transmembrane family member 2 (Q8CIF6)
Organism: Mus musculus (Mouse)
Function: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA and DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:20965152, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:28724756}; Multi-pass membrane protein {ECO:0000269|PubMed:20965152}. Cell membrane {ECO:0000250|UniProtKB:Q8NBJ9}. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (By similarity). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (PubMed:28724756). {ECO:0000250|UniProtKB:Q8NBJ9, ECO:0000269|PubMed:28724756}.
Interaction partners:
Sequence:
MIAWRLPLCVLLVASVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLLAIDRACPESGHARVLADSFPGSAPYEGYNYGSFENGSGSTDGLVESAGSGDLSYSYQDRSFDAVGPRPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
Protein: 5-hydroxytryptamine (serotonin) receptor 1A B (Htr1ab) (C0ITL9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEENNDTSFLFQNDSDLDHQTDNVTLPVKVPLSYQISTSLLIGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLDKWTLGQVTCDIFISLDILCCTSSILHLCAIALDRYWAITDPIDYMKKRTLKRAALLITVTWFVGFSISIPPMLIMKSQPKTCMISHDPWYTIYSTFCAFYIPLILMLVLYGRIFKAARFRIRKTVRKPEKKRVKCLTVSPALFKRANGELSKNWKSAVEPKPAACVNGAIKHAEDGESLEIIEVHSNSKNNLPLPNTPNSVPLFENKHEKNTEAKRKLALARERKTVKTLGIIMGTFILCWLPFFIKALVMPFCPTCVMPLWLQDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHFCRP
Protein: RNA-binding protein, putative (Q57W18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Bms1-type G domain-containing protein
- U3 small nuclear ribonucleoprotein
- Periodic tryptophan protein 2, putative
- Bystin, putative
- NLE domain-containing protein
- AATF leucine zipper-containing domain-containing protein
- BING4 C-terminal domain-containing protein
- RNA cytidine acetyltransferase
- RNA helicase
- Small-subunit processome Utp21 domain-containing protein
Sequence:
MSRVRILNLPRNCTEDQLRSNLLKSLPPDGPHIEITDCVILKRAPRPGARGRGTPRKSPAPDASEKGVIRMAFIGFRNAASGHFIVRHLDGTYFGEAKLQVHVAKGLADVGVTTNMRKKLGKEEQEENNQSSTIKYEGIGEKRARDVELGTKDGKAPNADGAGESEEDAKKRKRREEFVTERIRATTGPTWATEVLVPELSADAEASPTGDCDGGNGDAEPQGKKEQEDPNIELEKALERQKKLGEISDMDFLSSLAKESANQACSSNDASGGGGSDKRKGEVLEKGDESEEDQLLCPENPSPRDDQEEVVRESRRIRLGNIPFIATEEDVKQFASSHVGPVEAVHIPLTRDTKQSKGAAFVKFARVEDAVNALSRCQGAIFMGRLLRVSAATEDPYAKRSEETAGGLAGNSEFKRQKAKDRRKEGEGTSGVAPVAWSSTYMNSHTAVETVAKRLGVTADAVVSVDARGAAVRAAIAEAYLTSEIKEVLGDEGIDFSLLESARENLLKARSNTTILVKNVTLGDPAYAAQLSKMFLKYGTLEATAFPSAGAFALFRYVHQQDARVAFQRLSYKLFKNAPLFLEWAPIGSLSTAEDGGDCNDRVPSHSGNGRVDDVDEDGNHVGVAAGTPHFTLFITNIPFNSTKEDFNTFLLDSCPRLARAPDKFVERLELEQGKGRAFLTLRDASTMSYVQQRLNGRTMAGRTLACVVSKQTTAAINGASPASRAAGNGDGDGEDGVAKVFNVISRRGAGQSNGNISSDSNVPPGCDGLKLVVKNVPFEATERDIRDLFTAVSEVRSVRLPRKSHQFSSHRENNHRGFAFVEFLTEEEARRAKQTLGSTHLYGRHLVIQYAKLDES
Protein: Vacuolar sorting protein 9 domain-containing protein (Q55AA6)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MGDSKTPSLVIGENNQTTQPLTEKSETNDNDNNNNNNNIINNNNNNNNNNNNNNNNDNKSDNNNNNNNNIINNYNNEKDIINNQENINIETNNNNKPYTNNTNNTNNTNNTNNTNNNNNNNNNNNNNNNNNNNNNNNINNQQKSTFKSSLSSFLTSYYTSSTNNNNSDSNNNNNNNTNNTNNNKTTYFGHVRNSISYVTSSLPGIPSYSSLPSFNIPLISYISNSIPFPINYSRSSNLTNNNNNNNTTTTTSSSSSSSQPIPIKSNDKQQQQQQQQQQLNNPIAPINMSPNSFNSISIESNRLVISNSLGTEEQFQDIIRRLEQSNYKLHLISLDTFIENIKNDLTLSIDDISSSVQSYIATTLPILMHVCASIPFQTNEGAINMIESKSSSSSPLPPPLQTLMGKSINEIEIIIYEFMEQYIASRLYRRIFSSQEAIQKDTLLCEHISRFQHITPSNLDINDSIISTQFLEQIQEELLYISIFKSPREKLMCIKKSFKLLFQLLSKTQLPSVVGADLLLPIVIFCLIKSNLPFLWSNLQFISLFRDPTLIESETNYFLVTMITAASFIENMTFESLTDAVDPNAPPKSSDDNIIIESNNIEINKEKIEEQKENNNNNNNNNTLEPIIIDTLQQHESNKLVSDKEIVNENEREIKNSASSNDNDKMKIVTNNATEEEKKKLFKFYNSKPEELSVKEIKQLLNEYNSLVDKYFETK
Protein: Coagulation factor XI (A0A0G2K4I9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Tissue factor
- Coagulation factor VIII
- Coagulation factor XII
- Vitamin K-dependent protein C
- Prothrombin
- Coagulation factor X
- Thrombomodulin
- Coagulation factor VII
- Mannose-binding protein C
- Antithrombin-III
Sequence:
MTSLQQVLYFIFFASVSSECITKVFKDISFQGGDLSTVFTPSATYCQLVCTHHPRCLLFTFMAESSSDDPTKWFACILKDSLTETLPMVHMTGAVSGYSFKQCPQQLSACSKNVYVNLDMKGMNYNSSAVKNARECQERCTNDAHCQFFTYATGHFPSVDHRKMCLLKYTQMGTPTSITKLDSVVSGFSLKSCGLSNLACIRDIFPNTVLADLNIDSVLAPDAFVCRRICTHHPTCLFFTFFTQAWPKESQRHLCLLKTSESGFPSTRITKSNALSGFSLQHCRHSIPVFCHPNFYNDTDFLGEELDIVDVKGKESCQKMCSDNVRCQFFTYYPSRGSCSERNRRGRCYLKLSSNGSPTRILHGRGGISGYTLRLCKMDNVCTTKIRPRVFGGAASVHGEWPWQVTLHTTQGHLCGGSIIGNRWILTAAHCFSGTETPKTLRVYGGIVNQSEINEDTTFFRVQEMIIHDQYTSAESGFDIALLKLEPAMNYTDFQRPICLPSKGDRNVVHTECWVTGWGYTKSRDEVQSTLQKAKVPLVSNEECQTRYRKHKITNKVICAGYKEGGKDTCKGDSGGPLSCKHNGVWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKTQSE
Protein: Protein TOS2 (Target of SBF 2) (P50078)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Seems to be involved in the anchoring of CDC24 to the membrane of polarized growth sites.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Bud membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Kinesin-like protein KAR3
- Cell division control protein 24
- Probable circularly permuted 1,3-beta-glucanase TOS1
- Very long-chain fatty acid transport protein
Sequence:
MFSHYRYKENSCQKREAIPDKSRVSLTFLQKRTDSSNVTVAVAVAVPIGAIIIVLSVVLIVVYRRCKKEPSMQDFDPNFEGDLYYLPKMDSSMNSANSDSNATEKRFIYGGYDDFLQPSIENSQSFKDYVRRINEHAPSAYNIASLASQNNSKLSVPSKHIDLSNKISFESLENSELIVSPQHSNTGQDCDQRCDSTSNPDVNEKSSHNNDNRLKSNYTSRSGLEPQCSREEEENIDRIRSIYNIYFEKSNSTIRSSVTSSIRRDSKLNIATRKSVNMSSQDNPNDTTLIEQSHFGSTTVQEIDSSSSANEEYEDATDYLQVPAPQENKNIASSVYSEVATREKVIPESSLSLTFPPPNGLSTRITSSIYSDTVAKDHIHSAKAPVRALSEGSGQSNLTSAQQYSTYFIDHCNQSNDDNYYYNYPLPLEHPQNYENIGDLPTPTQFIYSTSSHSLTSFKGRPKPPKTLKHVPTARLNGTALNPMDHPEMFYSSPTKIPSTSLTKQFCTPLPYQLRQSVVMTNPSELSMKPRYKPAGSLRNLIKAQYLPGNSSTTTSSSLSQPPSTLSNAINFRVSGLLDDTDILQPPSVGEILPFKASTEDLRKQLGTSHNYEITPYENVHV
Protein: Kallikrein 1-related peptidase b22 (EC 3.4.21.35) (Beta-NGF-endopeptidase) (Epidermal growth factor-binding protein type A) (EGF-BP A) (Glandular kallikrein K22) (mGK-22) (Nerve growth factor beta chain endopeptidase) (Tissue kallikrein 22) (P15948)
Organism: Mus musculus (Mouse)
Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Interaction partners:
Sequence:
MRFLILFLTLSLGGIDAAPPVQSRILGGFKCEKNSQPWQVAVYYLDEYLCGGVLLDRNWVLTAAHCYEDKYNIWLGKNKLFQDEPSAQHRLVSKSFPHPDFNMSLLQSVPTGADLSNDLMLLRLSKPADITDVVKPIDLPTTEPKLGSTCLASGWGSINQLIYQNPNDLQCVSIKLHPNEVCVKAHILKVTDVMLCAGEMNGGKDTCKGDSGGPLICDGVLQGITSWGSTPCGEPNAPAIYTKLIKFTSWIKDTMAKNP
Protein: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Q8LBZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14671022}; Peripheral membrane protein {ECO:0000269|PubMed:14671022}; Matrix side {ECO:0000269|PubMed:14671022}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 2, mitochondrial
- Succinate--CoA ligase subunit alpha-1, mitochondrial
- Succinate--CoA ligase subunit alpha-2, mitochondrial
- Fumarate hydratase 2
- Fumarate hydratase 1, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- L-aspartate oxidase, chloroplastic
- Cytochrome b-c1 complex subunit Rieske-2, mitochondrial
- Succinate dehydrogenase subunit 3-1
Sequence:
MASGLIGRLVGTKPSKLATAARLIPARWTSTGAEAETKASSGGGRGSNLKTFQIYRWNPDNPGKPELQNYQIDLKDCGPMVLDALIKIKNEMDPSLTFRRSCREGICGSCAMNIDGCNGLACLTKIQDEASETTITPLPHMFVIKDLVVDMTNFYNQYKSIEPWLKRKTPASVPAKEILQSKKDRAKLDGMYECILCACCSTSCPSYWWNPESYLGPAALLHANRWISDSRDEYTKERLEAIDDEFKLYRCHTILNCARACPKGLNPGKQITHIKQLQR
Protein: Beta-glucuronidase (EC 3.2.1.31) (Beta-G1) (P08236)
Organism: Homo sapiens (Human)
Function: Plays an important role in the degradation of dermatan and keratan sulfates.
Subcellular location: Lysosome.
Interaction partners:
- Klotho
- Liver carboxylesterase 1
- UDP-glucuronosyltransferase 1A10
- N-acetylglucosamine-6-sulfatase
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A7
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1A9
- UDP-glucuronosyltransferase 1A8
- UDP-glucuronosyltransferase 1A1
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
Protein: Sphingomyelin phosphodiesterase (EC 3.1.4.12) (F7ETC0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPHHGASSGQGHLRAGWEQRLERSLPAPKLGLLWMGLGLALVLALFDSTVLWVPARAYPLPSQGHSVKFSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLKEPNVARVGSVAIKMCKMLNIAPLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGTDPNCADPLCCRRGSGWPPNSRTGAGYWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALNTITDLVWKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVDELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAPGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRADEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDAHSLWSRPLLC
Protein: Myocyte enhancer factor 2B (C9J4J4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPAPNSCPPEYGLGDPPPPPGLLQPPTLAPWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFPKTFPYPLLLARSLAEPLRPGPALRRLPLADGWPR
Protein: Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein) (Q6UX71)
Organism: Homo sapiens (Human)
Function: May play a role in tumor angiogenesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Hematopoietic lineage cell-specific protein
- Src substrate cortactin
Sequence:
MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVTQAFPHTEEEVEVDSHAYSHRWKRNLDFLKAVDTNRASVGQDSPEPRSFTDLLLDDGQDNNTQIEEDTDHNYYISRIYGPSDSASRDLWVNIDQMEKDKVKIHGILSNTHRQAARVNLSFDFPFYGHFLREITVATGGFIYTGEVVHRMLTATQYIAPLMANFDPSVSRNSTVRYFDNGTALVVQWDHVHLQDNYNLGSFTFQATLLMDGRIIFGYKEIPVLVTQISSTNHPVKVGLSDAFVVVHRIQQIPNVRRRTIYEYHRVELQMSKITNISAVEMTPLPTCLQFNRCGPCVSSQIGFNCSWCSKLQRCSSGFDRHRQDWVDSGCPEESKEKMCENTEPVETSSRTTTTVGATTTQFRVLTTTRRAVTSQFPTSLPTEDDTKIALHLKDNGASTDDSAAEKKGGTLHAGLIIGILILVLIVATAILVTVYMYHHPTSAASIFFIERRPSRWPAMKFRRGSGHPAYAEVEPVGEKEGFIVSEQC
Protein: Dihydroceramide fatty acyl 2-hydroxylase FAH1 (EC 1.14.18.7) (Fatty acid 2-hydroxylase 1) (AtFAH1) (O48916)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fatty acid 2-hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long-chain fatty acids (VLCFA). Probably involved in the resistance response to oxidative stress.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22635113}; Multi-pass membrane protein {ECO:0000269|PubMed:22635113}.
Interaction partners:
- Cytochrome b5 isoform B
- Cytochrome B5 isoform D
- Bax inhibitor 1
- Cytochrome b5 isoform A
- Cytochrome B5 isoform C
- Cytochrome b5 isoform E
- Fumarylacetoacetase
- Sphinganine C4-monooxygenase 2
- Sphinganine C4-monooxygenase 1
- Sphingoid long-chain bases kinase 1
Sequence:
MVAQGFTVDLKKPLVFQVGHLGEDYEEWVHQPIATKEGPRFFQSDFWEFLTLTVWWAVPVIWLPVVVWCISRSVSMGCSLPEIVPIVVMGIFIWTFFEYVLHRFVFHIKTKSYWGNTAHYLIHGCHHKHPMDHLRLVFPPTATAILCFPFWNIAKAISTPSTAPALFGGGMLGYVMYDVTHYYLHHAQPTRPVTKNLKKYHLNHHFRIQDKGFGITSSLWDIVFGTLPTTKAPRKEQ
Protein: Polyhedrin (Major occlusion protein) (P04871)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Major component of the virus occlusion bodies which are large proteinaceous structures termed polyhedra. These structures serve as the protective package for the virus particles outside the infected host and allow natural transmission of virus between insect hosts, assisting persistence in the environment. Forms the paracrystalline lattice of polyhedra and interacts with enveloped virions as well as other accessory molecules and structures to form a mature viral occlusion body.
Subcellular location: Host nucleus {ECO:0000269|PubMed:1962451}.
Interaction partners:
Sequence:
MPDYSYRPTIGRTYVYDNKYYKNLGAVIKNAKRKKHFAEHEIEEATLDPLDNYLVAEDPFLGPGKNQKLTLFKEIRNVKPDTMKLVVGWKGKEFYRETWTRFMEDSFPIVNDQEVMDVFLVVNMRPTRPNRCYKFLAQHALRCDPDYVPHDVIRIVEPSWVGSNNEYRISLAKKGGGCPIMNLHSEYTNSFEQFIDRVIWENFYKPIVYIGTDSAEEEEILLEVSLVFKVKEFAPDAPLFTGPAY
Protein: Interstitial collagenase B (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B) (Q9EPL6)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Interaction partners:
- Matrix metalloproteinase-9
- 72 kDa type IV collagenase
- Stromelysin-1
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 2
Sequence:
MPSLPLLLRLWAASSYSFPVIQDGLQKNVKTVWKYLENYYNLGKNMQAKNVNGKEVMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPDVAPYAITHNNPRWTKTHLTYSILNYTPYLSKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLSFHRGDHGDLYTFDGSKYHFAHAFLPGLGLGGNVHYDLDQKWTDNNEDFNLFYVTAHELGHSLGLSHSNDEEALMFPSYTWSNKDFVLNQDDINRIQALYGPSPNPIQLTDATLDPCNSGLTFDAIITYRGEVIFFKDRFYIRVISFLPEPLIDVIDLTWPNLPGKFDAAYEVSGVDELRFFKGSKVWAVQEQNVLEGFPMDIQSFFGFPSNVTNIDAAVCEEETGKTYFFVDHMYWRYDENTRSMDPGYPRLIAEDFPGIDYKVDDVIQKEDNFYFFHQSIQYRFNLKTRRIDDSSDINTWFNC
Protein: Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2) (O60241)
Organism: Homo sapiens (Human)
Function: Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:28891236}; Multi-pass membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:25326458}.
Interaction partners:
- E3 SUMO-protein ligase RanBP2
- Ran GTPase-activating protein 1
Sequence:
MENTGWMGKGHRMTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDHYLVNFTCLRPSPEEAVAQAESEVGRPEEEEAEAAAGLELCSGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSTAKREKRWSVSSGGAAERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV
Protein: Gap junction protein (Q8AX88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
Sequence:
MGDWSLLGNFLEEVQEHSTSVGKVWLTVLFIFRILVLGTAAESSWGDEQSDFMCDTLQPGCTNVCYDRAFPIAHIRYWVLQIVFVSTPSLIYMGHAMHTVRMEEKRKQKEQEEKAEAGKGEKEYLEHKEKFENTKTKIHLKGALLQTYVLSIVIRLVMEVTFIVIQYMMYGIFLDALYPCSMLPCPNPVNCYMSRPTEKNVFIVFMLVVAAVSLLLSVIELYHLGWKQCKKCLRKHADKHANDKIQNVKAVSAIEPIRTSIPMDLPENNQPRLSQTCTPPPDFNQCLRSNQGPTSPPHLHSHHLHHIHQTCQPFTNHLAHQQNSVNMAAERHHHSHDGLEPAVDFLQMHYGSPEARVRSEMTPSTPSTPSSHPGFFRDKRRLSKTSGTSSNRLRPSDLAV
Protein: Zinc finger protein CONSTANS-LIKE 14 (O22800)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- Zinc finger protein CONSTANS-LIKE 8
Sequence:
MGTSTTESVVACEFCGERTAVLFCRADTAKLCLPCDQHVHSANLLSRKHVRSQICDNCSKEPVSVRCFTDNLVLCQECDWDVHGSCSSSATHERSAVEGFSGCPSVLELAAVWGIDLKGKKKEDDEDELTKNFGMGLDSWGSGSNIVQELIVPYDVSCKKQSFSFGRSKQVVFEQLELLKRGFVEGEGEIMVPEGINGGGSISQPSPTTSFTSLLMSQSLCGNGMQWNATNHSTGQNTQIWDFNLGQSRNPDEPSPVETKGSTFTFNNVTHLKNDTRTTNMNAFKESYQQEDSVHSTSTKGQETSKSNNIPAAIHSHKSSNDSCGLHCTEHIAITSNRATRLVAVTNADLEQMAQNRDNAMQRYKEKKKTRRYDKTIRYETRKARAETRLRVKGRFVKATDP
Protein: Cysteine proteinase 1 (EC 3.4.22.-) (P04988)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cysteine proteinases 1 and 2 are believed to participate in the breakdown of protein during differentiation of Dictyostelium as a response to starvation.
Subcellular location: Lysosome.
Interaction partners:
- Cathepsin D
- Battenin
- Ceroid-lipofuscinosis neuronal protein 5 homolog
- Tripeptidyl-peptidase 1
Sequence:
MKVILLFVLAVFTVFVSSRGIPLEEQSQFLEFQDKFNKKYSHEEYLERFEIFKSNLGKIEELNLIAINHKADTKFGVNKFADLSSDEFKNYYLNNKEAIFTDDLPVADYLDDEFINSIPTAFDWRTRGAVTPVKNQGQCGSCWSFSTTGNVEGQHFISQNKLVSLSEQNLVDCDHECMEYEGEQACDEGCNGGLQPNAYNYIIKNGGIQTESSYPYTAETGTQCNFNSANIGAKISNFTMIPKNETVMAGYIVSTGPLAIAADAVEWQFYIGGVFDIPCNPNSLDHGILIVGYSAKNTIFRKNMPYWIVKNSWGADWGEQGYIYLRRGKNTCGVSNFVSTSII
Protein: T. brucei spp.-specific protein (Q57UV2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQGALSGEGGADSNIQNNLFSHMAERTDAVVKHTLQSEKSISPGADTLQRCEHKTLHLRTGGFSLFICLFVFESIPHISVQH
Protein: Probable nucleolar protein 5-1 (MAR-binding NOP56/58 homolog 1) (NOP58-like protein F108) (Nucleolar protein 58-1) (O04658)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for 60S ribosomal subunit biogenesis.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein At3g06530
- Nucleolar protein 56
- Nucleolar protein 56
- rRNA 2'-O-methyltransferase fibrillarin 2
- Putative WD-repeat membrane protein
- Nucleolar protein
- U3 small nucleolar RNA-associated protein 18 homolog
- rRNA 2'-O-methyltransferase fibrillarin 1
- H/ACA ribonucleoprotein complex subunit 2-like protein
- Putative rRNA 2'-O-methyltransferase fibrillarin 3
Sequence:
MLILFETPGGFAIFKVLNEGKLSNVEDLGNEFSTAKLARKMVKLVAFDKFDNTAEALEAVAKLLEGTPSKGLRKFLKANCVGETLAVADSKLGNIIKEKLKIVCVHNNAVMELLRGIRSQLTELISGLGDQDLGPMSLGLSHSLARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWFGWHFPELAKIVQDNILYAKAVKLMGNRINAAKLDFSEILADEIEAELKEAAVISMGTEVSDLDLLHIRELCDQVLSLAEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSLLNLAKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASVVGQAAPKNKGKISRSLAAKSVLAIRCDALGDSQDNTMGVENRLKLEARLRTLEGKDLGRLSGSAKGKPKIEVYDKDKKKGSGGLITPAKTYNTAADSLLQTPTVDSENGVKEKKDKKKKKKADDEEEAKTEEPSKKKSNKKKTEAEPETAEEPAKKEKKKKRKHEEEETEMPAKKKEKSEKKKKKKTEV
Protein: Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) (Q5RFU5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y4U1}.
Interaction partners:
- Methionine synthase
- Metabolism of cobalamin associated D
- 5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
- Methylmalonyl-CoA mutase, mitochondrial
- Host cell factor C1a.
- Diacylglycerol kinase.
Sequence:
MAISSERVEELLRTFRESLKAKGFEIYPFKVGWYNAVLTAAHHLQYPADTLAVLVISTPAMFECAFLPFLQSQSCESLRDPIDQCTAHTLSACISLCFANQFVDVSYDYEMLPSRKPKFLAQTAAHVSGAAYYYQTSDIHNPPWGEKKMFGVCVHPQLGGWFAIRALLVFRDVQAGAGFQQRDPADCVCTQEERIRLLESFNLRWRDWSYRDIVPAEDRYSDQQKQYFITPPGQRRALLRQWGYLTDTQS