wanglab/gogpt-training-data huggingface dataset:
Protein: GSK3B-interacting protein (GSKIP) (Q5PPI3)
Organism: Rattus norvegicus (Rat)
Function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9P0R6}. Nucleus {ECO:0000250|UniProtKB:Q9P0R6}.
Interaction partners:
- Glycogen synthase kinase-3 beta
Sequence:
METDCNPVDLSSMSGFEEGSELNGFEGTDMKDMQLEAEAVVNDVLFAVNNMFVSKSLPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQVEDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS
Protein: Knirps-related protein (Nuclear receptor subfamily 0 group A member 2) (P13054)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus.
Interaction partners:
- Zygotic gap protein knirps
Sequence:
MMNQDNPYAMNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNLSSISDCKNNGECIINKKNRTACKACRLKKCLMVGMSKSGSRYGRRSNWFKIHCLLQEQQQQAVAAMAAHHNSQQAGGGSSGGSGGGQGMPNGVKGMSGVPPPAAAAAALGMLGHPGGYPGLYAVANAGGSSRSKEELMMLGLDGSVEYGSHKHPVVASPSVSSPDSHNSDSSVEVSSVRGNPLLHLGGKSNSGGSSSGADGSHSGGGGGGGGGVTPGRPPQMRKDLSPFLPLPFPGLASMPVMPPPAFLPPSHLLFPGYHPALYSHHQGLLKPTPEQQQAAVAAAAVQHLFNSSGAGQRFAPGTSPFANHQQHHKEEDQPAPARSPSTHANNNHLLTNGGAADELTKRFYLDAVLKSQQQSPPPTTKLPPHSKQDYSISALVTPNSESGRERVKSRQNEEDDEARADGIIDGAEHDDEEEDLVVSMTPPHSPAQQEERTPAGEDPRPSPGQDNPIDLSMKTTGSSLSSKSSSPEIEPETEISSDVEKNDTDDDDEDLKVTPEEEISVRETADPEIEEDHSSTTETAKTSIENTHNNNNSISNNNNNNNNNNNSILSDSEASETIKRKLDELIEASSENGKRLRLEAPVKVATSNALDLTTKV
Protein: Probable calcium-binding protein CML15 (Calmodulin-like protein 15) (Q9FZ75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML47
- Probable calcium-binding protein CML48
- Probable calcium-binding protein CML49
- Proton pump-interactor 2
- At2g03740
- Probable calcium-binding protein CML1
- Probable calcium-binding protein CML46
- Peptide methionine sulfoxide reductase B4
- Probable calcium-binding protein CML40
- Probable calcium-binding protein CML21
Sequence:
MEDQIRQLKDIFDRFDMDADGSLTILELAALLRSLGLKPSGDQIHVLLASMDSNGNGFVEFDELVGTILPDLNEEVLINSEQLLEIFKSFDRDGNGFISAAELAGAMAKMGQPLTYKELTEMIKEADTNGDGVISFGEFASIMAKSAVDYFGLKINS
Protein: Coiled-coil domain-containing protein 32 (X1WGV5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Has a role in ciliogenesis and is required for proper cephalic and left/right axis development.
Subcellular location: Membrane, coated pit {ECO:0000250|UniProtKB:Q9BV29}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BV29}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BV29}.
Interaction partners:
- Large ribosomal subunit protein bL32m
- Large ribosomal subunit protein mL41
- Small ribosomal subunit protein mS33
- Mitochondrial ribosomal protein L20
- Large ribosomal subunit protein mL40
- Coiled-coil-helix-coiled-coil-helix domain-containing 1
- Large ribosomal subunit protein mL52
- Death-associated protein 3.
- Large ribosomal subunit protein uL30m
- 39S ribosomal protein L55, mitochondrial
Sequence:
MMIDDFETHAARSSGDLWSEVCSSLPEPREQHGGQFTDSFEPSSPGDPHTDSPRAANFSPWEPMADSEVYIAGLENRLKRIKGQTSEVTSREMLRSLSQAKKECWDRFLHDAQTSELFQEGNFDQSALEQFKRWLSPERVAINAEELEYLLLPTQNSETPASSSQTDKPCVEEEEECPSPEK
Protein: Cytochrome c oxidase assembly factor 6 (Q3E846)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery. {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome c oxidase subunit 13, mitochondrial
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Protein SCO2
- Cytochrome c oxidase subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
Sequence:
MGLFSFDGGKKESQPPNTRSQRKLCWESRDAFFQCLDKADILDAMDPKNSKSIKSHCKVENEKFEENCAHSWIKYFKEKRVIDFKREQTIKRIEQEAKQRERNQ
Protein: Kinetoplast DNA-associated protein, putative (Q381E6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
Sequence:
MLFRTVKLLRVSPFSVFMKDLKKTGELRNMSLANGARVASRMYRNLTPSQMRSLQERASKITYPALKAFNDFQRRECRNLTHMTNAERQRVVGEMWRKSAKRRELQLKKIQAKSRERREERKLRMQDEMKKRLFPTVRKYRIHKVDPADIKRPGFPDITASKKVKGGTMSKKSDRNRGTNKGKGVGTGKVVSMGKSAVRDKIAGTSRSANVSRVINTGRGAIKGKIASVRKAPSMSESMSKSKGKLTSPSKGAPVNLMKVRGRVPAAGKPGLKEVTNERRATRGSQTVRDVIIGRDAKRRLAVSRGVKNLKKNKESRKPPVRRR
Protein: Thiosulfate reductase, putative (Q72FP0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Iron-sulfur cluster-binding protein
- Sulfite reductase, dissimilatory-type subunit beta
- Sulfite reductase, dissimilatory-type subunit alpha
- Cysteine synthase
- Oxidoreductase, putative
- Cytochrome c nitrite reductase subunit NrfH
- Heterodisulfide reductase, iron-sulfur-binding subunit, putative
- Reductase, transmembrane subunit, putative
- Pyridine nucleotide-disulfide oxidoreductase
- Reductase, iron-sulfur binding subunit, putative
Sequence:
MWCYAPHDDVLRHASGHHAPCDHSRHDVGHTAEERMAERRSVYSVCGMCSVRCPIMVDVEDGKARWIQGNPHSALKGALCARGAAGIALENDPERPLRPLIRVGARGEGKWREASWDEALDHIASRLKIVTAEHGGRSILWSDRGGPFMDLHQAFVRGLGSPNYCNHDASCARNVQHACRSVTGMGRKEVVYDFRNCKHIVLQTRNILEAINVGEANAVLDALGNGCRLSVIDIRATVSSSKAHDFFMVRPGTDYAFNLAVINVLIGEKLYDAAYVERHVDGFDALSTFVAPYTPAWAEGETGIAAAAITDFARKLAEAAPHVVWHPGWMTARYNDSFMVSRTAYIINALMGAIGAKGGLPLANTAKDVGRKGLKKFVDLLPKPDEKRADGVGWRHTQFDAGPGIVNFAYDAIESGDPYPVKAYICYRHDPLMAMPDPDTLRRKLDHLDLLVSVTFSWSDTAWFADVVLPLSTYLSRESVVAHKGGLKPQFFVRKRAMQPVADSRAEWEIISGLSRRLGIDALAFDSIEDMWNYQLDGTGVSIADFDAKGFVELADKPLYRDIEGFTFPTPSGKIEMVSGKWAKAGLDTLPPYVSPAHPPQDGFRVAFGRCALHTQGHTVNNPLLHEQMPENTAWMHPTRAAALGIACGDLVEVFSARGSAGIMPVTVTPYVHPEALFMIHGFGHRLPVESRAYGRGVADQDLMPGGLSVYDKSGGCVSLQEHFVTVRKAGVR
Protein: DNA gyrase subunit A (EC 5.6.2.2) [Cleaved into: Mle GyrA intein] (Q57532)
Organism: Mycobacterium leprae (strain TN)
Function: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01897}.
Interaction partners:
- DNA gyrase subunit B
- DNA-directed RNA polymerase subunit beta
- Beta sliding clamp
- DNA replication and repair protein RecF
- Dihydropteroate synthase
- DNA polymerase I
- DNA-directed RNA polymerase subunit alpha
Sequence:
MTDITLPPGDGSIQRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCVSGNSLVRLLFGKSIRIGDIVTGAQFNSDNPIDLKVLDRHGNPVVADYLFHSGEHQTYTVRTTEGYEITGTSNHPLLCLVNVGGIPTLLWKLIGEIRSGDYVVLQRIPPVEFGPADWYSTMEALLFGAFISGGFVFQDHAGFNSLDRDYFTMVVNAYDTVVGGLRCISSRITVSGSTLLELDVYNLIEFKKTRLSGLCGQRSADKLVPDWLWHSPSTVKRAFLQALFEGEGFSSILSRNIIEISYSTLSERLAADVQQMLLEFGVVSERYCHTVNEYKVVIANRAQVEMFFTQVGFGVTKQAKLIRDVVSMSPCVGMDINCVPGLATFIRKHCDNRWVEEDSFNQHNVDCVQHWHHHSAEIVGHIADPDIRAIVTDLTDGRFYYARVASVTDTGIQPVFSLHVDTEDHSFLTNGFISHNTEARLTPLAMEMLREIDEETVDFISNYDGRVQEPMVLPSRFPNLLANGSGGIAVGMATNIPPHNLYELADAVFWCLENHDADEETMLVAVMERVKGPDFPTAGLIVGSQGIADAYKTGRGSIRIRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRTGRLAGISNVEDQGSDRVGVRIVIEIKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQMICYYVEHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVITLIRASQTVDIARVGVVELLDIDDIQAQAILDMQLRRLAALERQRIIDDLAKIEVEIADLGDILAKPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDEDLIAREEVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRAGLVKKSKLTDFDSNRSGGIVAINLRDNDELVGAVLCAADGDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGRGGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLMNLGEGDTLLAIARNAEESADGVSVKVMISRSRVLSFFGSDSNTSPDRT
Protein: Ras-related protein Rab-3C (EC 3.6.5.2) (P62823)
Organism: Mus musculus (Mouse)
Function: Protein transport. Probably involved in vesicular traffic (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rabphilin-3A
- Regulating synaptic membrane exocytosis protein 2
- Synaptosomal-associated protein 25
Sequence:
MRHEAPMQMASAQDARFGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILAGNKCDMEDERVVSTERGQRLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQSTRLKETPPPPQPNCGC
Protein: Armadillo repeat-containing protein 12 (Q80X86)
Organism: Mus musculus (Mouse)
Function: Essential for male fertility and sperm mitochondrial sheath formation. Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath. Facilitates the growth and aggressiveness of neuroblastoma cells (By similarity). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5T9G4}. Mitochondrion outer membrane {ECO:0000269|PubMed:33536340}; Peripheral membrane protein {ECO:0000269|PubMed:33536340}.
Interaction partners:
- TBC1 domain family member 21
- Histone-binding protein RBBP4
Sequence:
MGKTIPRFLEQLDLIKSFVGLATGAGALYLLYKAVRTGLKCHPPLCSNSPICIARLAIERERHGRDSGEIRRLLNSLDCKQDEYTRSMILHNITRCVYLLEAEASSCTMDDIDLVADMLDEKDNSVKIQALNALKAFSGIRKFRLKIQEHCIKVLELISTIWDLELHVAGLRLLNNLPLPDYVHPQLRRVMPALMEIIQSDCILAQVQAVRLLSYLAQKNDLLYDILNCQVRPNFLNLFQSSQPGSLLFEVLVFAEHLSEGRNATHYRAVKWHYNEQSLHEALFGDESRLADRLLSLVIHPEEEVQIQACKVIVSLQCPQDLGSRPSSCRPSHSCFKTGK
Protein: Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Q7TNJ4)
Organism: Rattus norvegicus (Rat)
Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:12843293}. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons.
Interaction partners:
- Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
Sequence:
MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSSSGLCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLIVRHNNITSISTGSFSTTPNLKCLDLSSNRLKSVKSAMFQELKVLEVLLLYNNHISYLDPAAFGGLSHLQKLYLSGNFLTKFPMDLYVGRFKLADLTFLDVSYNQIASIPMHHINLVPGKQLRGIFLHGNPFVCDCSLYSLLTFWYRRHFNSVTDFKHDYTCRLWLDSRHSHQLLLLQDSFLNCSHSVINGSFHALGFIHEAQVGERAIVHCDGKTGNGNTDFIWVGPDNRLLEPDKDTGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHHAHEAFNTAFTTLAACVVSIVLVLLYLYLTPCPCKCRDKRQKNALNQSNAHSSILSPGPTRDASAEDRKAGKRVVFLEPLKDPAVGQNGKVKLVPSKTVIAEGILKSSRAKSDSDSVNSVFSDTPFVAST
Protein: Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) (Q9JHI7)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06265}. Nucleus {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q06265}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). {ECO:0000250|UniProtKB:Q06265}.
Interaction partners:
- Exosome complex component 10
- Exosome complex exonuclease RRP44
- Exosome complex component RRP40
- Exosome complex component CSL4
- Exosome complex component MTR3
- Exosome complex component RRP4
- Exosome complex exonuclease RRP42
- Exosome complex component RRP41
- Exosome complex component RRP46
- Exosome complex component RRP43
Sequence:
MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVFRCSKIAGVKVAEITELIQKALENDQRVRKEGGKFGFAESIANQRITAFKMETAPIDTSNIEERAEEIIAEAEPPPEVVSQPVLWTPGTAQIGDGIENSWGDLEDSEKEEEEEEGGIDEAVILDDTKMDTGEVSDIGSQGAPIVLSDSEEEEMIILEPEKNPKKIRAQTSANQKAPSKGQGKRKKKKRTAN
Protein: Protein ORANGE-LIKE, chloroplastic (DnaJ-like cysteine-rich domain-containing protein Or-like) (Q8VYD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be associated with accumulation of carotenoids in chromoplasts.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:25675505}.
Interaction partners:
- Phytoene synthase 1, chloroplastic
- Probable pectinesterase 67
- Expressed protein
- Probable pectinesterase 49
- Invertase/pectin methylesterase inhibitor family protein
- Calcineurin-like metallo-phosphoesterase superfamily protein
- Putative clathrin assembly protein At1g25240
- AT3g52570/F22O6_50
- Probable pectinesterase 50
- Nuclear envelope-associated protein 2
Sequence:
MTCFSSATPHRHHLLLSSPSTSKSLLRFPSSYLKPSPSLLFHGSSRSLLSCSDGSNNRPPPSGDTVPNNFCIIEGSETVQDFVQMQLQEIQDNIRSRRNKIFLLMEEVRRLRVQQRIKSVKAINEDSELEATEMPEITSSIPFLPNVTPKTLKQLYSTSVALISGIIFFGGLIAPNLELKVGLGGTSYEDFIRSLHLPLQLSQVDPIVASFSGGAVGVISTLMLIEVNNVKQQEKKRCKYCLGTGYLPCARCSASGVCLSIDPITRPRATNQLMQVATTKRCLNCSGAGKVMCPTCLCTGMVTASEHDPRFDPFD
Protein: WASH complex subunit 4 (E7F4L4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- WASH complex subunit 5
- WASH complex subunit 3
- WASH complex subunit 1
- WASH complex subunit 2C.
- Uncharacterized protein.
- Duboraya.
Sequence:
MAVDSLSPDWEFDRFDDGSQKIHTEVQVKNYERFLEEYIAQLQGIEEALDDSIGDVWDFTLDPITLKLLPYEQSSLLELIKTDNKVLNKVITVYAALCCEVKKLKHEAETKFYNGLLYYGEGVSDTSVVEGESQIQMGRFVSFLQELSCFVSRCFEVVVNMVHQLAALYNSSKGATKIIESTGVHFQTVYEHLGELLVVLITLDEIMENHATLKEHWKMYKRLLKSVHHNPAKFAIPEEKLKPFEKLIFKLEGQLLDSMIFQACVEQRFDNPGENVSVSKNSAFAEEFAYNIRTIFANVESKLGEPSEIDQRDKYTGVCGLFVLHFHIFRAVDKKIYKSLLDVCKKVPAVTLAANIIWFPDTFLINKVPAAAKLMDKKSLQSIRSSRDVFLQQKAQTLMKDMQSYYIFVTSWMMKMESILSKEPKPDKLSEDLSNRCNIFVQGILYAYSISTIIKTTMNMYMSMQRPMTKTSVKALCRLVELLKAVEHTFHRRSLVVADSVSHITQQLQSQALVSISMAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKERRLIMSLALSVGTQMKTFKDEELLPLQLVLKKLDLISELRERVKVQCDCSFLYWHRTVFPIYLDDVYENAVDAARIHYMFSALRDCVPTMLHAKHMESCDQLLECYDTEIMEILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGMKDLAHFFSLKPIRFFNRFIDIKAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHVFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLRKKFYIFSQFMYDEHIKSRLIKDIRFFRETKDQTDQKYPFERAEKFNRGIRKLGLTPDGQSYLDQFRQLISQIGNAMGYVRMIRSGGLHCCSSAIRFVPDLEDIVNFEELVKEEGLSEETQKASSQLDCVLSDLTSNSAEGTEYFKMLVGVFAPEFRSIKNMHLRNFYMIVPPLTVNFVEHSISCKEKLNKKNKVGAAFTDDGFAMGVAYILKLLDQYQEFDSLHWFQAVREKYVKEMNAVVKEQNVQSTSQDEKLMQTMNLTQKRLDVYLQEFELLYFSLSSARIFFRADKTAAEETQEKKDKEEGAKTGPVSMTAEGSPVEPSAK
Protein: rRNA N-glycosylase (EC 3.2.2.22) (Q7BQ99)
Organism: Shigella dysenteriae
Interaction partners:
Sequence:
MKIIIFRVLTFFFVIFSVNVVAKEFTLDFSTAKTYVDSLNVIRSAIGTPLQTISSGGTSLLMIDSGTGDNLFAVDVRGIDPEEGRFNNLRLIVERNNLYVTGFVNRTNNVFYRFADFSHVTFPGTTAVTLSGDSSYTTLQRVAGISRTGMQINRHSLTTSYLDLMSHSGTSLTQSVARAMLRFVTVTAEALRFRQIQRGFRTTLDDLSGRSYVMTAEDVDLTLNWGRLSSVLPDYHGQDSVRVGRISFGSINAILGSVALILNCHHHASRVARMASDEFPSMCPADGRVRGITHNKILWDSSTLGAILMRRTISS
Protein: Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) (Q99626)
Organism: Homo sapiens (Human)
Function: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P43241}.
Interaction partners:
- Keratin, type I cytoskeletal 20
- POU domain, class 5, transcription factor 1
- Protein LIAT1
- Transcription factor GATA-6
- Keratin, type II cytoskeletal 7
- Mucin-2
- Transcription factor SOX-2
- Hepatocyte nuclear factor 1-alpha
- Pro-glucagon
- Hepatocyte nuclear factor 3-beta
Sequence:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVTQ
Protein: Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C] (P02788)
Organism: Homo sapiens (Human)
Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
Subcellular location: [Isoform 1]: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.; SUBCELLULAR LOCATION: [Isoform DeltaLf]: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm.
Interaction partners:
- Alpha-lactalbumin
- Myeloperoxidase
- Neutrophil elastase
- Cathepsin G
- Albumin
- Neutrophil gelatinase-associated lipocalin
- Clusterin
- Myeloblastin
- Intelectin-1
- Ceruloplasmin
Sequence:
MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK
Protein: Antigenic mitochondrial protein HSP60, putative (Q4X1P0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Chaperonin, putative
- Iron-sulfur cluster biogenesis chaperone
- GrpE protein homolog
- CCT-theta
- T-complex protein 1 subunit alpha
- ATP synthase subunit beta
- Heat shock protein 90
- Endoplasmic reticulum chaperone BiP
- ATP-dependent Clp protease proteolytic subunit
- DnaJ homolog 1
Sequence:
MQRALSSRTSVLSAASKRAAFTKPAGLNLQQQRFAHKELKFGVEARAQLLKGVDTLAKAVTSTLGPKGRNVLIESPYGSPKITKDGVSVAKAITLQDKFENLGARLLQDVASKTNEIAGDGTTTATVLARAIFSETVKNVAAGCNPMDLRRGIQAAVDAVVDYLQKNKRDITTGEEIAQVATISANGDTHIGKLISTAMERVGKEGVITVKEGKTIEDELEVTEGMRFDRGYTSPYFITDTKSQKVEFEKPLILLSEKKISAVQDIIPALEASTTLRRPLVIIAEDIEGEALAVCILNKLRGQLQVAAVKAPGFGDNRKSILGDLAVLTNGTVFTDELDIKLEKLTPDMLGSTGAITITKEDTIILNGEGSKDAIAQRCEQIRGVMADPSTSEYEKEKLQERLAKLSGGVAVIKVGGASEVEVGEKKDRVVDALNATRAAVEEGILPGGGTALLKAAANGLDNVKPENFDQQLGVSIIKNAITRPARTIVENAGLEGSVIVGKLTDEFAKDFNRGFDSSKGEYVDMISSGILDPLKVVRTALLDASGVASLLGTTEVAIVEAPEEKGPAAPGMGGMGGMGGMGGGMF