Protein: Protein glp-1 [Cleaved into: glp-1/Notch intracellular domain] (P13508)
Organism: Caenorhabditis elegans
Function: Essential signaling protein which has a major role in germline and embryonic development; involved in cell fate decisions that require cell-cell interactions. Probable membrane-bound receptor for putative ligands lag-2 and apx-1. Upon ligand activation, and releasing from the cell membrane, the glp-1/Notch intracellular domain (NICD) probably forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes; targets in the germline include lst-1 and sygl-1. Involved in the specification of the cell fates of the blastomeres, ABa and ABp. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and ABp descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Required in postmitotic neurons in order to maintain the developmentally arrested larval state known as dauer, probably in response to lag-2. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Required for oocyte growth control. Plays a negative role in lifespan.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7607081}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:18599512}. Note=Localized to axons during dauer larval stage. {ECO:0000269|PubMed:18599512}.; SUBCELLULAR LOCATION: [glp-1/Notch intracellular domain]: Nucleus {ECO:0000269|PubMed:9003776}. Note=The glp-1/Notch intracellular domain (NICD) may become localized to the nucleus after ligand activation. {ECO:0000269|PubMed:9003776}.
Interaction partners:
- Suppressor of hairless protein homolog
- Insulin-like receptor
- Female germline-specific tumor suppressor gld-1
- C-mannosyltransferase dpy-19
- Forkhead box protein O
- Neuronal acetylcholine receptor subunit eat-2
- Nuclear hormone receptor family member daf-12
- Sex-determining protein fem-1
- Fem-3 mRNA-binding factor 1
- Sex-determination protein fem-3
Sequence:
MRVLLILLAFFAPIASQLMGGECGREGACSVNGKCYNGKLIETYWCRCKKGFGGAFCERECDLDCKRGEKCIYDVYGENPTCICQDCEDETPPTERTQKGCEEGYGGPDCKTPLFSGVNPCDSDPCNNGLCYPFYGGFQCICNNGYGGSYCEEGIDHCAQNECAEGSTCVNSVYNYYCDCPIGKSGRYCERTECALMGNICNHGRCIPNRDEDKNFRCVCDSGYEGEFCNKDKNECLIEETCVNNSTCFNLHGDFTCTCKPGYAGKYCEEAIDMCKDYVCQNDGYCAHDSNQMPICYCEQGFTGQRCEIECPSGFGGIHCDLPLQRPHCSRSNGTCYNDGRCINGFCVCEPDYIGDRCEINRKDFKFPDIQSCKYNPCVNNATCIDLKNSGYSCHCPLGFYGLNCEQHLLCTPTTCANGGTCEGVNGVIRCNCPNGFSGDYCEIKDRQLCSRHPCKNGGVCKNTGYCECQYGYTGPTCEEVLVIEKSKETVIRDLCEQRKCMDLASNGICNPECNLEECNFDGGDCSGGQRPFSKCQYPARCADQFANGVCNQECNNEECLYDGLDCQSELFRCPAHIRKHCIERRGDGVCNLECSFIGCGFDGGDCNNGTEAIILSDIRIKVQIDPIEFQATGGETLMQISANLRATVRIQRDELGPLVFRWDGEHEMERVEMNSSKLEDQFVLSHHVRRYRQAVVTGIVLYLEVEEICKPEFCRFSTAQSVVDLIAAGLVKSDGRMSLGLPITEAMVAVPKRNEIDEGWSRSQVILFACIAFLAFGTVVAGVIAKNGPERSRKRKMVNATVWMPPMESTNEKGRRNQSNHSSQCSLLDNSAYYHPNTKRHCSDYSTGYNGEQYSQIYPQTLANGYPGDYNELNFDFQSETFAPADLPADEIPLHVQAAGPDAITAPITNESVNQVDSKYRRRVLHWLAANVRGKPEDVITTEAIRCLKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKRLLKEIDELDRNGMTALMLVARELGKHQVEMAELLLSKGAKLDYDGAARKDSNKYKGRTALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANERHRNDIMRQQIVKSGHGAKSGRQTVKNIKRAGSRKTPTSAASSRETNHLTPPPSDGSFSSPSPHYYPTTTSTPNRMETSPEYMFNHEMAPPVNAMWYTTPPPYQDPNYRHVPPNTAFQNAEQMNGSFYC