wanglab/gogpt-training-data huggingface dataset:
Protein: Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form] (Q2M385)
Organism: Homo sapiens (Human)
Function: Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity).
Subcellular location: [Isoform 1]: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28705375, ECO:0000269|PubMed:31537793}; Multi-pass membrane protein {ECO:0000255}. Note=Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles. {ECO:0000269|PubMed:28705375}.; SUBCELLULAR LOCATION: [Macrophage-expressed gene 1 protein, processed form]: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:A1L314}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A1L314}. Note=Proteolytically processed in lysosomes, leading to its maturation and forms pores in the membrane of antigen-containing phagosomes. {ECO:0000250|UniProtKB:A1L314}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:28705375}.
Interaction partners:
- Perforin-1
Sequence:
MNNFRATILFWAAAAWAKSGKPSGEMDEVGVQKCKNALKLPVLEVLPGGGWDNLRNVDMGRVMELTYSNCRTTEDGQYIIPDEIFTIPQKQSNLEMNSEILESWANYQSSTSYSINTELSLFSKVNGKFSTEFQRMKTLQVKDQAITTRVQVRNLVYTVKINPTLELSSGFRKELLDISDRLENNQTRMATYLAELLVLNYGTHVTTSVDAGAALIQEDHLRASFLQDSQSSRSAVTASAGLAFQNTVNFKFEENYTSQNVLTKSYLSNRTNSRVQSIGGVPFYPGITLQAWQQGITNHLVAIDRSGLPLHFFINPNMLPDLPGPLVKKVSKTVETAVKRYYTFNTYPGCTDLNSPNFNFQANTDDGSCEGKMTNFSFGGVYQECTQLSGNRDVLLCQKLEQKNPLTGDFSCPSGYSPVHLLSQIHEEGYNHLECHRKCTLLVFCKTVCEDVFQVAKAEFRAFWCVASSQVPENSGLLFGGLFSSKSINPMTNAQSCPAGYFPLRLFENLKVCVSQDYELGSRFAVPFGGFFSCTVGNPLVDPAISRDLGAPSLKKCPGGFSQHPALISDGCQVSYCVKSGLFTGGSLPPARLPPFTRPPLMSQAATNTVIVTNSENARSWIKDSQTHQWRLGEPIELRRAMNVIHGDGGGLSGGAAAGVTVGVTTILAVVITLAIYGTRKFKKKAYQAIEERQSLVPGTAATGDTTYQEQGQSPA
Protein: Taste receptor type 2 member 105 (T2R105) (Taste receptor type 2 member 5) (T2R5) (Taste receptor type 2 member 9) (T2R9) (Q9JKT4)
Organism: Mus musculus (Mouse)
Function: Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 1 member 3
- Taste receptor type 1 member 2
Sequence:
MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF
Protein: Synembryn-A (Q54DU0)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}.
Interaction partners:
- Phosducin-like protein 1
Sequence:
MEVFNEQYQNQRDSESVWVETLKKFNTESADKRVFTDKVNLNTKEQFTYNLFHYLKNEFNPSQTVKPSIETMVQVLISLRISLREFTEKDRDIVKNELNIFFKLGNIGEAEKIKIYDNSIREEALKCIVNCISRDPVIQNTFLVEMNGPITLTREVKKNSAEMSEGLLDVIYKVLVHCCAKPEIKLALRPEGLLEFVTEQLLTKVTTTDAITKSAPLLSDLCRLLFTLTIHLGPLEGGRPTPPNHLELEGCRRLLPIFKKIITQYTPGNSASDPIYNLKCAVISALINTPKDLYDELIDEIPLTYFQEIFKSQIHLLSSPETAAEFLPILMLLTNTAENVISTRQQLKEMTFPYDLIKETDEPLSVGIEPPEEVKKTGISSKLIPFMTGSDIGLKHFVSEYFFMICDEDANEVCRLTGFGNAAGLLVTRGLMSLGGK
Protein: Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) (Q811Q9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. Plays an important role in ovary maturation and the maintenance of sperm production.
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y5K3}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y5K3}.
Interaction partners:
- Choline kinase alpha
- Choline/ethanolamine kinase
- Choline/ethanolaminephosphotransferase 1
- Cholinephosphotransferase 1
- Choline-phosphate cytidylyltransferase A
- Mitogen-activated protein kinase 10
- Phosphoethanolamine/phosphocholine phosphatase
- Mitogen-activated protein kinase 9
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase 3
Sequence:
MPVLTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADESSCQCQAPHEKLTVAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPNKTSPPSSPKAASASISSMSEGDEDEK
Protein: Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM5) (TRIM5alpha) (Q0PF16)
Organism: Macaca mulatta (Rhesus macaque)
Function: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17156811}. Nucleus {ECO:0000269|PubMed:17156811}. Note=Predominantly localizes in cytoplasmic bodies (PubMed:20357094, PubMed:22078707). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (PubMed:17156811). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (PubMed:20357094). {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:20357094, ECO:0000269|PubMed:22078707}.
Interaction partners:
- Microtubule-associated proteins 1A/1B light chain 3B
- Microtubule associated protein 1 light chain 3 beta
- Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
- E2 ubiquitin-conjugating enzyme
- Peptidyl-prolyl cis-trans isomerase A
- DNA dC->dU-editing enzyme APOBEC-3G
- Transportin-3
- T-cell surface glycoprotein CD4
- Small ubiquitin-related modifier
- Interferon-induced GTP-binding protein Mx2
Sequence:
MASGILLNVKEEVTCPICLELLTEPLSLHCGHSFCQACITANHKKSMLYKEGERSCPVCRISYQPENIQPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADIREEKASWKIQIDYDKTNVSADFEQLREILDWEESNELQNLEKEEEDILKSLTKSETEMVQQTQYMRELISELEHRLQGSMMDLLQGVDGIIKRIENMTLKKPKTFHKNQRRVFRAPDLKGMLDMFRELTDARRYWVDVTLAPNNISHAVIAEDKRQVSSRNPQIMYQAPGTLFTFPSLTNFNYCTGVLGSQSITSGKHYWEVDVSKKSAWILGVCAGFQSDAMYNIEQNENYQPKYGYWVIGLQEGVKYSVFQDGSSHTPFAPFIVPLSVIICPDRVGVFVDYEACTVSFFNITNHGFLIYKFSQCSFSKPVFPYLNPRKCTVPMTLCSPSS
Protein: Rabconnectin-3B, isoform A (Rabconnectin-3B, isoform B) (SD05962p) (Q9W543)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rabconnectin-3A
- MIP32831p1
- LP07472p
Sequence:
MVSTNLVVPVVLWGPTAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSPRCLLVGHSAPVLCLVRASLLPENNFLVSSSENGEMCTWDLTDGKCMEAVKLPQVHTQIQSYHTANSEDVRLFCIGYYAEIMVMDPFSLEVIYVLSSKVKPDWISAIHVLRPMRRKDDVVLAITTTGTVKVWTLTGNENKHAEPIYENESKEIRCLNAITMNCCAQNQRTVLLVCTKYWQIYDAGDFTVLCSVIAPARERWQGGDFITSDRVMLWTDEGKGYLYKLPANCIPDNKEFHSKSVVRDAPYLYYVLQHAGDKVLSCPPAMKLLQGAGGQHNLLRGDSEGYISVWNVPEVPLDNISILQAKQMPPRPLKPHVCTSLVEAWSIMDPPPVGILDQLSRITESPVKLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQLLVGIKQNFSDWPSHQILYGHRGRVNCLLCPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCSPRILKCICSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVWQMETGHLDRVLHGMLAEEVLSACDEQAEDGGSGGGGGSNGASASEMGMANPAVHFFRGLKSRNMNAIRHATQRGITQLQQLQGHNQGNFDFLMKHRSNPLVIQGLRTNPKDAESHILFFDIEGLIFELHSEEYAQMTPATLESLGVHLQNPKDGKSMHLDASKKIGDFFNKVKNKAVDVEKILKDKDKHGLVQKFKEKTEIVEKKVQAKVESLQKAVEPHEEQQDLKSKIASKMEVTHVMEVAQLLLSLLHSWGLDPHLDKMCETRLGLLRPIVPISYGVLSKAGYMSLLLPTWQNNYAIPPGIQLPSSSKKRPLPEELQRLEHLTAVFTSRLHWELSTTLTTNHILALVAMSNTLLSMSAASFLPDSEKHKKLQRLAQRTDSTLSNEEEREELMAHHISQIKHAWSLLATHHCFLLPDKIEALEPKKFKRPQVEMMVKRWQHHCIEIREAAQQILLGELTRMGKKGRKQLVESWAQYLPLYTHTEPIVGAQQQLALISQPASGGAGSGSGGNGGVGVGVSGGGGAGSGSGPGGSVPGGDAHQDEDYEEEEEEIIRKPSSLSELKRKQTTAVILLGVIGAEFGQDISQESPNHRGSISMATGANLTSGVAGGERRKSSVVEGFGIANNLARLTSMALAHLLYAPPSPKLPQYTPLRRAAIDLLGRGFTVWEPYLDVSKVLLGLLEISCEGKAVPNLNYKLPLTPQADACRTARHALRLIATARPAAFITTMAREVARYNTMQQNAQSINTPLTQSVLHKAKGEILQCVEMLIDKMQSEIAGLLVEVMDIALHCVDGNELKNRGLAELCPAICKFNQISHCAQTRRIAVGANSGNLAIYELRQNKCQMIPAHTHPITSLAFSPDGKYLVSYSCAENRLSFWQTSTGMFGLGQSQTRCTKGYSTAPIPDVSRLNPMRLAKLVWINNRTVTLMLADGSETRFNV
Protein: Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) (P07310)
Organism: Mus musculus (Mouse)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subcellular location: Cytoplasm.
Interaction partners:
- Creatine kinase B-type
- Beta-enolase
- Myosin light chain 1/3, skeletal muscle isoform
- Creatine kinase S-type, mitochondrial
- Myoglobin
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin regulatory light chain 11
- Troponin I, fast skeletal muscle
- Phosphoglycerate mutase 2
- Titin
Sequence:
MPFGNTHNKFKLNYKPQEEYPDLSKHNNHMAKVLTPDLYNKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLANLSKHPKFEEILTRLRLQKRGTGGVDTAAVGAVFDISNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK
Protein: B box-type domain-containing protein (Q54W55)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MAGKFDNKCTLHNDYDYRFICSDCRVPVCDYCIVSKNHHRSHSIDFITSENCNQIFQEFKNNNFQFLIKCLDGDKELLNKSNEIFNELEEEHIHNVNTISNEFKQLHTILDSVEKDTIKHLVSHYDENKETHSKISKKLENNSKNAHLITNKYKDTINNFNIQQIFNNDQNIKGNNHQHLELLKHCHQSQMLVKEKNTENKNIDLLNEFNKVTIENSMDFVKNSIKDTFKIKLSSATYKDPKRVKLGGGEYFIYKDGCVIPNGTLYLALGPSIKNLTIGSIPATIQRIALLNGFNLQLTEGLLPNSVQWLHIGAIRKPLIKKSIPQSVSFLFLLDGFNQEISEIPPNVTQIYLGDTSFKIPQTLIKSVRVYKTPSCKQDLNGFNEVLWNSNGYSQIEM
Protein: Roundabout homolog 3 (Roundabout, axon guidance receptor, homolog 3 (Drosophila)) (A8DZ85)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEFRRTLDALVVVFALICLSQGSRPRLEDAAPRIVEHPSDLIVSKGEPATLNCKAEGRPTPMVEWYKDGERVETDREDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGVYVCVARNYLGEAVSRNASLEVAILRDDFRQTPSDVVVAAGEPAVMECIPPRGHPEPTISWKRNNVKVNDKDERITIRGGKLMISNTRKSDAGMYVCVGTNMVGEKDSDPAELVVFERPMFVRRPVNQVVLADDTVDFQCEVQGDPAPTIRWKKEEGELPRGRFEIRADNSLRLTQVKAEDEGSYTCLSENSVGKAEASGSLQVHVPPQIVVRPRDQISAQGRTVTFLCGTKGNPPPAVFWQKEGSQVLLFPSQPPSQSGRFSVSLSGELTITDVHSEDSGYYICQAISVAGSILTKALLEVESTPSDRIPPIIRQGPANQTLAPGTTAQLQCHVMGNPLPSIQWERDGQRILGIDERISLMENGTLQITALQETDSGAYTCVASSLSGETSWSGVLTVKESGGLSASPVSEPYQLPGPPQKPVVTDVTRNSVTLTWQPNAHEGGAAVTSYIIEAFSQSAGSTWQTVADFVKLEKHTVTGLSPNTIYLFIVRAVNAYGLSDPSPISEPVRTQDVSPTGQGVDHRQVQRELGEMSVQLHEPVLLTASSVKISWNVDRQSQYIQGYRLLYRPVGGSWSQQEVKGATERSAVIANLLKGTEYEIKIRPYFNEFQGLDSRSQTLRTPEEVPSAPPRAVNVATVKLSNSSSISVSWQPPPTDMQNGVIQEYKVWCLGNDSQTRYNINQTVDGSVLSTVLKGLLPGVLYQVEVAAVTSAGVGKHSQPVSVLIKLPAEQPTVTGGGSESEENVSLAEQITDVVKQPAFIAGIGGACWVILMGFSVWIYCRRKKRKELSHYTASFAYTPAVGFPHGESSGLNGRPGMLGANMGNYPWLADSWPTTNLVHNGKDSVNCCTSKHETPERYYNEAGISNYLNQNEKYSADSNEGPIYSTIDPTSEDLRSFTAQYSQHTTPYASTPIMPFTNQAPCSPEQDGSHWMTQPGTSNAQYAQPDRSKTENVKQPKQKLMGKPVKTPSLNWMDALPPPPISGDLEQCDEEDDNELIQDMGSDEEEWCPPLPERSYLMDGMVEDGPVPPPRGEASSPTTSYSHQSTATLTPSPRDDGHFHDIPRLHQLEQPHMTRRLPCGPVPVPRAPSPPLTQSNPNLSANQECPDNTVPHRSAHKRDLSQGAAQSVENISNTTPGRARPSADHTSSGQKSKVKKKASKSAQYRRDILQGDLPPPPEPPPEDQDNCAHVGGFECGQTSLERAGSSNSSMERREQSTPNRKNSAHRRIDADDDLIPYNKPNFLSRGQMSSNCSTTGSSSSRGSTGSRGQGTGRKRNDEMR
Protein: At1g61980 (F8K4.17 protein) (Mitochondrial transcription termination factor family protein) (O80703)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MYSLIRHGRSLVELQKWRHLRVLVQKASPLSNSFSSASAARLSPRVGRKGKSFTVSYLVDSLGLPKKLAESVSRKVSFEDKDNPDSVLNLLRSHGFTDSQISTIVTDYPQLLVADAEKSLAPKLQFLQSRGASSSELTEIVSTVPKILGKRGHKTISVFYDFIKETLLDKSSKSEKSCQPFPQGNLENKIRNLSVLRELGMPHKLLFPLLISCDVPVFGKEKFEESLKKVVEMGFDPSTSKFVEALCVVQRLSDKNIEDKVNAYKRLGFDVEYVWTVFKRWPNFLTHSEKKILNTIETFLGLGFSRDEFSVLIKRFPQGIGLSAEMVKKKTEFLVKKMNWPLKALVSNPAVLGYSLEKRTVPRGNVVQALISKGLIGSELPSISRVFVCTDQVFLNRYVKRHEDKQLETELMAIYRAS
Protein: Putative pentatricopeptide repeat-containing protein At5g08490 (Q9FNN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 3
- Probable protein phosphatase 2C 55
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase subunit 2.
- NADH-ubiquinone oxidoreductase chain 2
Sequence:
MGPLRQFVQNFRLLSGFGTDHRVFLDVVKACASVSDLTSGRALHGCVFKLGHIACSEVSKSVLNMYAKCRRMDDCQKMFRQMDSLDPVVWNIVLTGLSVSCGRETMRFFKAMHFADEPKPSSVTFAIVLPLCVRLGDSYNGKSMHSYIIKAGLEKDTLVGNALVSMYAKFGFIFPDAYTAFDGIADKDVVSWNAIIAGFSENNMMADAFRSFCLMLKEPTEPNYATIANVLPVCASMDKNIACRSGRQIHSYVVQRSWLQTHVFVCNSLVSFYLRVGRIEEAASLFTRMGSKDLVSWNVVIAGYASNCEWFKAFQLFHNLVHKGDVSPDSVTIISILPVCAQLTDLASGKEIHSYILRHSYLLEDTSVGNALISFYARFGDTSAAYWAFSLMSTKDIISWNAILDAFADSPKQFQFLNLLHHLLNEAITLDSVTILSLLKFCINVQGIGKVKEVHGYSVKAGLLHDEEEPKLGNALLDAYAKCGNVEYAHKIFLGLSERRTLVSYNSLLSGYVNSGSHDDAQMLFTEMSTTDLTTWSLMVRIYAESCCPNEAIGVFREIQARGMRPNTVTIMNLLPVCAQLASLHLVRQCHGYIIRGGLGDIRLKGTLLDVYAKCGSLKHAYSVFQSDARRDLVMFTAMVAGYAVHGRGKEALMIYSHMTESNIKPDHVFITTMLTACCHAGLIQDGLQIYDSIRTVHGMKPTMEQYACAVDLIARGGRLDDAYSFVTQMPVEPNANIWGTLLRACTTYNRMDLGHSVANHLLQAESDDTGNHVLISNMYAADAKWEGVMELRNLMKKKEMKKPAGCSWLEVDGQRNVFVSGDCSHPRRDSIFDLVNALYLQMKEPVVF
Protein: Tetrapyrrole methylase domain-containing protein (Q38DI8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Enoyl-CoA delta isomerase 1, mitochondrial
Sequence:
MSVSSQIGIRRHALLPFIGSVASRRSFRGCQWTHHSCRFMSSCNPLRGSFKYRHNRTLPEDAVNPLTTPTNVDAGVLHVVSVPIGNLKDFSIRALDVLRQVDYIVTTDRPATKTLLDLVQIESQGRLIHYSRSNRTTTKEKLVELLLGGRRMALVCTSGTPCVGDVGGELVREMQAEGVRVAAVPGSCALTCALAVAGVTTSLHEVSATADTNRACAAKRPRIGSLRDGSFYFGNVLPESHGERLRVLRTAVGEATHPCVFYEVPRRLLSVLQDIALVLPKRRVVLTHELTKVNESIHADVAEKLLSFYSRQEANMLLKKGQLVLIIDGPDENEMRERLECEALKRQRLRRSFASLTGRCGNMEEKNTHDVGKTKRMRLCRRSLLRKKRREALISRIEKEQERIRMTMLINRTDATRD
Protein: Aquaporin-5 (AQP-5) (P55064)
Organism: Homo sapiens (Human)
Function: Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:23473857}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Cell membrane {ECO:0000269|PubMed:23830519, ECO:0000269|PubMed:26569106, ECO:0000269|PubMed:8621489}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:26569106}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. {ECO:0000269|PubMed:26569106}.
Interaction partners:
- Aquaporin-10
- Putative aquaporin-12A
- Aquaporin-11
- Transient receptor potential cation channel subfamily V member 4
- Surfactant protein C
- Uteroglobin
- Aquaporin-7
- Aquaporin-3
- Keratin, type II cytoskeletal 5
- Aquaporin-9
Sequence:
MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR
Protein: Poxin (EC 3.1.-.-) (Immune nuclease) (Protein B2) (Q01225)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses.
Interaction partners:
Sequence:
MAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIPNLVKVKLGENDTENLSSTISAAPSR
Protein: trypsin (EC 3.4.21.4) (G8CXX6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Plasminogen activator inhibitor 1
Sequence:
MSGILVWSLILALTALTVCKAQRRPFPSESHDKPGVLCLNGGSSLSSLSGRHLLCLCAEGFSGSRCETDTSVSCFDGIGQLYVGPVSKSASGRECLEWDSEKALEIGVYLKSLIVGGHKHCRNPDFSRRPWCFVKTPSGIMKEDCDIPRCSKDHGSDQDSLAVSQSGWRCGQAEGRSMKVVGGALSMLERHPWMAAIYSRKSRGRFFTCGGSLISPCWILTAAHCFPDGAQTLVHKLSVVLGKKAINETDVQSEQEFRVSELFIHEHFDNTDGNFNNDIALLKIRGPDGRCAKESSSVKTVCIPGPNVSLSDGTSCTVTGYGREHEGSWFYSQYLKEAQVKILSQDLCSSKEYYGNMITENMLCAGSPDWSSDACKGDSGGPLVCRVQDRVFLFGVVSWGEGCSRAFRPGVYAKVSNYYHWILEKSGLTSLS
Protein: Transcription factor MYB98 (Myb-related protein 98) (AtMYB98) (Q9S7L2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds to the motif 5'-GTAACNT-3' in the promoter of target genes (e.g. DD11 and DD18) and promotes their expression within synergid cells (e.g. in the filiform apparatus) in ovules. Required for the formation of the filiform apparatus during synergid cell differentiation in the female gametophyte. Involved in pollen tube guidance to the micropyle.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:17693534}. Note=Localized to the nuclei of the synergid cells. {ECO:0000269|PubMed:17693534}.
Interaction partners:
- Protein LURE 1.2
- Probable helicase MAGATAMA 3
- ECA1 gametogenesis related family protein
- Uncharacterized protein
- Defensin-like protein 222
- Defensin-like protein 218
- RING-finger, DEAD-like helicase, PHD and SNF2 domain-containing protein
- Eukaryotic aspartyl protease family protein
- ECA1 gametogenesis related family protein
- ECA1 gametogenesis related family protein
Sequence:
MENFVDENGFASLNQNIFTRDQEHMKEEDFPFEVVDQSKPTSFLQDFHHLDHDHQFDHHHHHGSSSSHPLLSVQTTSSCINNAPFEHCSYQENMVDFYETKPNLMNHHHFQAVENSYFTRNHHHHQEINLVDEHDDPMDLEQNNMMMMRMIPFDYPPTETFKPMNFVMPDEISCVSADNDCYRATSFNKTKPFLTRKLSSSSSSSSWKETKKSTLVKGQWTAEEDRVLIQLVEKYGLRKWSHIAQVLPGRIGKQCRERWHNHLRPDIKKETWSEEEDRVLIEFHKEIGNKWAEIAKRLPGRTENSIKNHWNATKRRQFSKRKCRSKYPRPSLLQDYIKSLNMGALMASSVPARGRRRESNNKKKDVVVAVEEKKKEEEVYGQDRIVPECVFTDDFGFNEKLLEEGCSIDSLLDDIPQPDIDAFVHGL
Protein: Vacuolar fusion protein CCZ1 homolog A (F4I2S4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in membrane trafficking through the secretory apparatus. In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
Subcellular location: Endosome {ECO:0000269|PubMed:24824487}. Prevacuolar compartment {ECO:0000269|PubMed:24824487}.
Interaction partners:
- Vacuolar fusion protein MON1 homolog
- Vacuolar sorting protein 18
- Protein VACUOLELESS1
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar sorting protein 3
- Vacuolar sorting protein 39
- Vacuolar protein-sorting-associated protein 33 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- C18orf8
- Ras-related protein RABG3b
Sequence:
MASMSSGDESLRLCMFDLRRGQTEGQELEKILFFYPADLDFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMVVEKNKETGAIWRIDALRRVLKEVHSLFVMFHGSIRALIEKEPTGGLTRSLLYPFITDYLSTFQIWSLSEDCCCEFFVGKKLQLPTFRETLRERGTVQMLTLARDTAVEVQSLVQVLDSCAGSLRCHSMILFQDLLVSTTLSADDTVDLFTFAVMRLTSKALSSDTSSWSYLRKGPGSSEISSRSNLAPVGSIDSLHSRNGNNMHHVIRPLQNDKWTKGKDGFLITDIWGLETGGSPDSAIPTIWLQQTQERMYLLAYQHKSLTLLLLMPTNAIVNGDLSISAVKQQVIEDASLRILKIEENISRGWGGENAYHIKGYRYLVVDNDTKVSRSSPSGKVTTLAKESLLALNKLREEVDSEKSRAKGQEKDMEICIRAKNNVWVIARVTRGKELYMALEKGSDTLLDTTDAVGRFSNRYCSGAFLMD
Protein: Putative methyltransferase NSUN7 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 7) (Q14AW5)
Organism: Mus musculus (Mouse)
Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity.
Interaction partners:
- tRNA
- 5-cytosine rRNA methyltransferase NSUN4
- RNA cytosine C
- tRNA
- tRNA
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Nucleolar complex protein 2 homolog
- Probable rRNA-processing protein EBP2
- Methionyl-tRNA formyltransferase, mitochondrial
Sequence:
MLDPTSERDLFDQENMEEISQLASLEMSGDVVANTNSTVVLEKPSYPDSVYVTAANIFQGIRIQRSPDKVIINYGSEPLQPSSSRSEDESFQRLSYELAFSTLKYQDILESILIDSYIFSSTTIASQLNSLIIVMLYDFQDRKFQPRILSENEETIPEVQEVENLLNGFKTKLAAALARCRIKHDALSIYHILPETVRKQEQRASTLPLYAWINTSKISLEEVYNNLRRKGYSKVKSITSVNEKVYAVDQHCFNVLIFPAHLKTDLLNIDLIKDYKLIFQDKSRSLAVHSVKALINIDDDVLMVNTGSWYTVAHMSILTSGHTSKIFVCGIQQEEKDFNARKLFTRMGCQNIEILHETFLSIESKDHRLQNVKVILLLPRCSSLGVSNPVEFILNEHEDKSLLQDLSQGGLPKDKLETLVQQQFEQLTHAMKFTKVQAIVYCTCSVSKEENEDVVEKALEYQSSGVKMQPYRLSPPVLPLCTLKEIELSMDRFFRLEPSDMNNGCFLSILTRERDPSETVSVKDVLARAAAKGLLEGVEVGKTLKRDKKRKKSKALPSRAPHHGDPLRDHLAVDGNDTSNVQMKISELLHRESKISTSTKMSAPAKTVSQAGTSSQVRKPSKPLSTPLVRNFSRPVERPTNFVRARPEGKVIPLKPIEIVLPPVIFPLSSQGPRVQMPATHFYYRFIGSKVGVPRYLTSSTSRRKEKVKESTTSSHVRHPRPWL
Protein: Zinc-finger of a C2HC-type (Q38BB2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPPLFRICPLCQQGFGSASLGIHVPQCYQKALKRWKLNPNGPMPVMPNISPTPHKGTKSSAGGVACGNGANGARTLNEHDPFANGSEHPEGNMNLHPCSRCGRKFLFDRIAYHESVCKGNVKRKVFDSSKQRAIEGQYSGGCFGAPSAKGRKKAAPGASSPAPGVPRTRWREQHREFIEAMRAARQARQTSAAMWGEPCAKEPCPNNRQPRAPPAIARQQRGAQQRQQRTANPMGITFSGTQASSHSASSRPSHGNTFGNRCEGFGSRVSGRVGGGGGGGQIRIANDNTTSLGMLQAFGRA