wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial Rho GTPase 1 (Miro) (EC 3.6.5.-) (Q94263)
Organism: Caenorhabditis elegans
Function: Mitochondrial GTPase involved in mitochondrial trafficking (By similarity). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). Plays a role in maintaining mitochondrial morphology.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IXI2}; Single-pass type IV membrane protein {ECO:0000255}.
Interaction partners:
- HAP1 N-terminal domain-containing protein
- Serine/threonine-protein kinase pink-1, mitochondrial
- E3 ubiquitin-protein ligase parkin
- Transmembrane GTPase fzo-1
- FIS1-related protein fis-1
- Probable voltage-dependent anion-selective channel
- Mitochondrial import receptor subunit TOM20 homolog
- Kinesin heavy chain
- IRG-type G domain-containing protein
- MFS domain-containing protein
Sequence:
MSDDETLADVRIVLIGDEGCGKTSLVMSLLEDEWVDAVPRRLDRVLIPADVTPENVTTSIVDLSIKEEDENWIVSEIRQANVICVVYSVTDESTVDGIQTKWLPLIRQSFGEYHETPVILVGNKSDGTANNTDKILPIMEANTEVETCVECSARTMKNVSEIFYYAQKAVIYPTRPLYDADTKQLTDRARKALIRVFKICDRDNDGYLSDTELNDFQKLCFGIPLTSTALEDVKRAVSDGCPDGVANDSLMLAGFLYLHLLFIERGRHETTWAVLRKFGYETSLKLSEDYLYPRITIPVGCSTELSPEGVQFVSALFEKYDEDKDGCLSPSELQNLFSVCPVPVITKDNILALETNQRGWLTYNGYMAYWNMTTLINLTQTFEQLAYLGFPVGRSGPGRAGNTLDSIRVTRERKKDLENHGTDRKVFQCLVVGAKDAGKTVFMQSLAGRGMADVAQIGRRHSPFVINRVRVKEESKYLLLREVDVLSPQDALGSGETSADVVAFLYDISNPDSFAFCATVYQKYFYRTKTPCVMIATKVEREEVDQRWEVPPEEFCRQFELPKPIKFSTGNIGQSSSPIFEQLAMMAVYPHLRRVFYLNDSNLLSKITFGAAIVALAGFLVLKNL
Protein: Putative forkhead-related transcription factor fkh-5 (Q19802)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Binds to DNA sequence motif 5'-CTGTTTCA-3'. Regulates expression of a class of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-4 and fkh-3.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Fork-head domain-containing protein
- Forkhead box protein F
- Fork-head domain-containing protein
- Forkhead transcription factor fkh-6
- Forkhead box protein pes-1
Sequence:
MQYALTVIFQSILFVQCQVGEAAFVISQEHEVSKSISINMTLFPSIKWIIHKSFYLYLTYFVMSQQTLPCFQAADSYNYSHSLPKVQFARFSKYTPQSISYSSTQMYQQKEYSDHITEMTNVHKSRKRKLMVTEDQWGSQITIPKVIQNRPLIEKWFVQKRFKMVKVRNIQRPQLSYQLLSALTCLNSPDGMISTTEIYSFILHHWRYYRYANENWKNSVRHVLCKCQLFDVLQVEGLSRKGNVYKLKRPDNVEKEMIDVKTLGCMQKDSRGIDFYIKMLAGQIGLPRHLFYSIVGNEMPEYAGPENSAIFYHLLSMRKIIPKLETRYFLEHWQMEHKATEPMFFEEFVPYSTSLVSCVENISSYGEGVGPGNDELYDLSDRQIICFHKNIRAYHSLQKRCHKMNYSNWMTPSLIYVQEAVMDKEIVEDDIRNGTIECEGVARKEEAKKNFQDPALISIYN
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C) (Q6STE5)
Organism: Homo sapiens (Human)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:14701856}.
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- AT-rich interactive domain-containing protein 1A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF complex subunit SMARCC1
- SWI/SNF complex subunit SMARCC2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Zinc finger protein DPF3
- Protein polybromo-1
- Actin-like protein 6A
Sequence:
MAADEVAGGARKATKSKLFEFLVHGVRPGMPSGARMPHQGAPMGPPGSPYMGSPAVRPGLAPAGMEPARKRAAPPPGQSQAQSQGQPVPTAPARSRSAKRRKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRVDIQEALKRPMKQKRKLRLYISNTFNPAKPDAEDSDGSIASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTPTTQETDGFQVKRPGDLSVRCTLLLMLDYQPPQFKLDPRLARLLGLHTQSRSAIVQALWQYVKTNRLQDSHDKEYINGDKYFQQIFDCPRLKFSEIPQRLTALLLPPDPIVINHVISVDPSDQKKTACYDIDVEVEEPLKGQMSSFLLSTANQQEISALDSKIHETIESINQLKIQRDFMLSFSRDPKGYVQDLLRSQSRDLKVMTDVAGNPEEERRAEFYHQPWSQEAVSRYFYCKIQQRRQELEQSLVVRNT
Protein: Calcium-dependent mitochondrial ATP-magnesium/phosphate carrier protein 2 (AtAPC2) (Mitochondrial ATP-Mg/Pi carrier protein 2) (Q9FI43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Calcium-dependent mitochondrial carrier protein that catalyzes the import of ATP co-transported with metal divalent cations across the mitochondrial inner membrane in exchange for phosphate (Pi). Can transport phosphate, AMP, ADP, ATP, adenosine 5'-phosphosulfate, sulfate and thiosulfate, and, to a lesser extent, other nucleotides. Binds calcium ions Ca(2+). Mediates also calcium uptake.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:22062157}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Anaphase-promoting complex subunit 1
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- Anaphase-promoting complex subunit 13
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 2
- NAD
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
Sequence:
MEATKSSKQNCCNPVKKPGPVSIDHVLLALRETREERDLRIRSLFSFFDSENVGYLDCAQIEKGLCALQIPSGYKYAKELFRVCDANRDGRVDYHEFRRYMDDKELELYRIFQAIDVEHNGCISPEGLWDSLVKAGIEIKDEELARFVEHVDKDNDGIIMFEEWRDFLLLYPHEATIENIYHHWERVCLVDIGEQAVIPEGISKHIKRSNYFIAGGIAGAASRTATAPLDRLKVLLQIQKTDARIREAIKLIWKQGGVRGFFRGNGLNIVKVAPESAIKFYAYELFKNAIGENMGEDKADIGTTVRLFAGGMAGAVAQASIYPLDLVKTRLQTYTSQAGVAVPRLGTLTKDILVHEGPRAFYKGLFPSLLGIIPYAGIDLAAYETLKDLSRTYILQDAEPGPLVQLGCGTISGALGATCVYPLQVVRTRMQAERARTSMSGVFRRTISEEGYRALYKGLLPNLLKVVPAASITYMVYEAMKKSLELD
Protein: Epithelial calcium channel (Transient receptor potential cation channel subfamily V member 6) (Q6JQN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPPAISGEINHWWRQMRFRLQHKKGWNEMLDETFLMQTKRVNDIPLFSATKENNAACIKKLLDCSSTDIFERGELGETALHVAVMNDNFEAAVALMNGAPELINEPMTSELYHGLTALHIAVINQNPNLIWEMIKRGADVTTPRVTGMYFRKRREGLFYYGEHILAFAACVGNKDIMSMLIKAGANIRAQDSRGNTILHLLVLQPNKTTACQIFDFLLAQDAEQDSALPLDMVPNYKGLTPFKLAARDGNVFQHLVNRRKVVQWSLGPVSSYLYDLTEIDSRVDEHSVLEIIATSHKKEARRILELTPVRQLITLKWNLYGKHYFRSLMVIYLVYISIFTVCCINRPLKGIPENYTKAGNDHTIKIKKTFKESYQSYTDQLRLIGEIISLIGAIIILLIEIPGILAVGVKRFFGQTALGGLFHVTLISYALLVLLLCGLRVTGIQGELIPMAFSLILGWFSLVYFARGFEMLGPYVIVIQKSIFGDITKFMWLSIIFLIGSSAALWIFYMTQEPLALPQYRSFPITLFSQFEVSVGQIDLPVDHTLFTHPVVYWTHVCFSLISNVLLFNLLVAMMSDTQWRVTQERDELWRTQVVATTLMLERKLPQCLWPRLGVCGLMFGLGERWYLRVEDRNDIMAQKLKRYVDAFPKDVEAPKEEKPSKSDGEQSITESNKEKSKKSKQYWSLIRRSIECEKEECVDCPNFKFL
Protein: Zinc finger protein rst2 (P78871)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- cAMP-dependent protein kinase regulatory subunit
- Fructose-1,6-bisphosphatase
- cAMP-dependent protein kinase catalytic subunit
- Transcriptional repressor tup11
- Transcriptional repressor tup12
- Transcription factor ste11
- Transcriptional activator hap2
- Transcription factor atf1
- Transcription factor pcr1
- Transcriptional activator hap5
Sequence:
MTRESLAPIASKANTLSESKVSENLMSINSDSGTSNANTPSSVTSNSKPVASSTAAKKDPNAPPQKVKQYVCETCTRAFARLEHLKRHIRSHTNEKPFTCSEIDGLPTGCGRQFSRRDLLLRHQQKIHRNPQPRRRRRSTTALPNPSLSNVSVSTTNLASKPVISLPQADSIDKFRYPKLHAALQAQLANNSGSFSASWLQAQQQRLVSAGNGRETVNASASGAVNPTSSQWSDQRLGVPYGPDSPLYYRRATIASDLRPSVYQHPQLYDFNRPESLSGQLDDESLARMPYSPNAVSRNYAMNMTLPESIPEGYEIDKLDWMSFSESLNLPTFNQPSGPSDVSASFLNLQAMPSPHASPKDSLINKSNSYFFQNPPKSNSVDYTRLDNLEHMRQSCISPSGTNFSPSCYSPESLMQQPLTLSPSSIPSGLPTYAHVNSPLGTEQYPSEAYPPKGYVDMEGRISEGIKEEGISLSEEITDKDQAFASMGYFDSYNFEGVENSNSLNNEGDQMETNFQSEKLDNSNSIPFFNFNSFNNNGANWSSDFNYPVSETSGLLTDNNRNQPPSF
Protein: Lymphocyte antigen 6 complex locus protein G6f (Q5SQ64)
Organism: Homo sapiens (Human)
Function: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12852788}; Single-pass type I membrane protein {ECO:0000269|PubMed:12852788}.
Interaction partners:
- Growth factor receptor-bound protein 7
- Lymphocyte antigen 6 complex locus protein G6d
- Lymphocyte antigen 6 family member G6E
Sequence:
MAVLFLLLFLCGTPQAADNMQAIYVALGEAVELPCPSPPTLHGDEHLSWFCSPAAGSFTTLVAQVQVGRPAPDPGKPGRESRLRLLGNYSLWLEGSKEEDAGRYWCAVLGQHHNYQNWRVYDVLVLKGSQLSARAADGSPCNVLLCSVVPSRRMDSVTWQEGKGPVRGRVQSFWGSEAALLLVCPGEGLSEPRSRRPRIIRCLMTHNKGVSFSLAASIDASPALCAPSTGWDMPWILMLLLTMGQGVVILALSIVLWRQRVRGAPGRDASIPQFKPEIQVYENIHLARLGPPAHKPR
Protein: Secreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (Q9Z0K7)
Organism: Mus musculus (Mouse)
Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (By similarity). In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have a immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P55000}.
Interaction partners:
- Secreted Ly-6/uPAR domain-containing protein 2
- Neuronal acetylcholine receptor subunit alpha-7
- Ly-6/neurotoxin-like protein 1
- Lymphocyte antigen 6H
- Lymphocyte antigen 6K
- Neuronal acetylcholine receptor subunit alpha-3
- Neuronal acetylcholine receptor subunit alpha-9
- Ly6/PLAUR domain-containing protein 6
- Neuronal acetylcholine receptor subunit alpha-5
Sequence:
MTLRWAMWLLLLAAWSMGYGEAFRCYTCEQPTAINSCKNIAQCKMEDTACKTVLETVEAAFPFNHSPMVTRSCSSSCLATDPDGIGVAHPVFCCFRDLCNSGFPGFVAGL
Protein: BZIP transcription factor (O18660)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSIVCTLEQKVNFFKAAATTKNLLILKNNTDTNYINNYKQDNPSNNKFPRIQAQSNNSHLQHQQQLQQKLAQLHHYSQQKLSGSDFPYGPRPPTGGKEEKLLLLAPPGKLYPEASVSTAMPEVLSGTPTNSHNKANIAMMNNVRLSNISPTLSMNGSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSGYGDGMMAQSPSQGGNGPQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRSREKRRYNDMVLEQRVIELTKENHVLKAQLDAIRDKFNISGENLVSVEKILASLPTSEQVLSNTKRAKMSGSGGSSSGSSPSGSGSGEGSPQGGHNGYPVGPPLSPLIYGPNGNARPEATVKSVHHIHHAGVAPPPTHLQQLVVPQSQTQHLYQPQPQQHQPHQQQQISQPPQQQQQQQEPSPSAGSSSPVISDPHNRPPSTTIANLQVQLQQALNRNVRPEDLDSLRKVVAAGALYNAARVVGAPPPPPSAGLYVPAPSAYKDHLEAAAAWSHNVEAAVSSSAVDAVSSSSVSGSAASVLNLSRRACSPSYEHMLSSTTSSTLSSASSSGAVSGDDEQEHEPAHMAPLQLQRTSPQQGSDANNCLPLKLRHKSHLGDKDAAATALLSLQHIKQEPNCSRASPPAWNDGGDNSSDERDSGISIASAEWTAQLQRKLLAPKEANVVTSAERDQMLKSQLERLESEVASIKMILAE
Protein: Uncharacterized protein (Q38DR0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLHEGLVNDIMSYHFIAVNPPTPCLGGPSLLHVYFKSPLLILGFLIRLFIFCASPFARTAGFRVVEFVAVVILSMGVDKKISSLEDFFKRVSFPLQPLHYETKLVLDTFLDKGGFLNICDMTFGSPFHDGRRSGAGELSWMDVANSNPNGKTALALFRFLAPGGYFCYLLEALSLPQHDFAVKLKKSWKGDAETEIETGSYLRYFDFPFSTFHPTFHELFEEAPEANLFDLPRSRCPPLMLVPFWAPPLVTRLEPSSRRVLTSLRCSPISYFILRMLLYGVRRTEECCSDVVRLPRINAMGGKINVFFKAVVRLFKGSYITGLPLYHRLLTAYIQYFVSSTCIQKLSSKRSFGDIQWSVSDVTAALLLSAPSHLWARSVSKVDREKHRLSCRDVASAALVFRLVPFLTECLFALCQKDRGRIYTSCWEGDNAVRKDFCDSHITPAVWDVLNPHISFYRNTLSVLRQALISFENYDDCRREHFNNALELWYAVVSPTGRVDDVSESYVVHHYEAYSFILFDVILMFLRSSFLEAIDVTGATIWSRCVEVFTSTAVQNVFREVSNATTNARCGIIETICRYFTLNWMGEDGIVRIMKPHAEETLHFLAEVYLATEVRLGEDGISDDTKCSLRLSLDYLAKSFDGIIRVVDERRSSRVSRLTAATSASSRPSGEGEYTDRVGDSKDLYFRGTRMSCKFSGPVDVRFNAENEGIPFYAQSSNAGFSDEFPHLVTLTEWMETALVFVFELYYKSWIPQCSNGHKLWLLSSDKHCCVNHPQQSAIWECFLCEEVYGSCCRSKPRCPRGGSLTRTEISQSISFPYCNQCFVMFKLGSVAYNKPQSDTLFCSNCASRPFKRISCRFFASHIVVVLCIIVSLMVFLFFTI
Protein: DUF4291 domain-containing protein (Q54UT6)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSNKNYKRIIKAVYNDETIRVYQAYNKEIAEGAVKNQRFVDPWLTTRTTWIKPSLCWMMYRAGYGYKDKNQERILAIDIKREAFEWILDTYYDNNNENLNDLKAYAKNSLVIQWDPERSIKIGKLENGELRSIQIGIKPNLTQKFNNEWIAEINDITDIVHQIKREIDDGNIEKAISLLPIEKVYTPINVKF
Protein: Ciliary microtubule inner protein 2A (Q6J272)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:G3X6E2}.
Interaction partners:
Sequence:
MTTTQKHDLFTPEPHYVPGYAGFFPQLRYQVGNTYGRTTGQLLTDPSVQKSPCSVLSPMSKPKFIEDFSQSKPPRVPCQDLTEPYIPHYTSLKPSKNFEILGQLPPLEVDAQEPPGVENIPRQILLPAGFTPDTPHPPCPPGRKGDSRDLGHPVYGEEAWKSATPVCEAPRQHQLYHCQRDEYPPPARRQQETLDVGSFQRLPQLDHPNLIQRKAISGYAGFIPRFTWVMGLNYRDGVMQAMDEFDKSQFLFRNPHCDLGEKLPGTHWPSNHIYSSQGLIPFYMGFIPAMQDNYALTFGNSTRRAYWKEWAKRNHTL
Protein: Rolling pebbles isoform 7 (Q8WTD2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynapse {ECO:0000256|ARBA:ARBA00034110}.
Interaction partners:
Sequence:
MPSLQQIALAMEGDQSELQTPPLPINPPPKVMANGIVYGFRTRHLSCIEENDSDSLHGSSIPHAYDMMQQADETSQKLNANEEQDESGSEDGGLENLDDTIAMIDESRLLEADYLDELVAEEQLQEQDEDEEESSDLVDSGNVEEDFWQPSFNRNDIMMTSVYGALNGSLTSEVSSTAAPGYSECATPRKEAEPVYATPEKRRASNRSFDSTCASLTSSLYGGSMNSSLDLKYSFLGGGDSVSGGISGTSTLRGTSVPPMDLSMISSDGVSALDWGSASVSCVLDSGDGNPAEELNEEMAAKCLSAAESDLQSIRRLLEHDASGSVCPSCRISFDKGKRRKLIDTCGHERCYSCMFRNDQCPMCMNSSLKDVDGANAQGYDTGIGGSTSTIVSPLGSPQPQLRSHAQRNAALARYMQQHRQESQSPDYHHRYASNGKLPRAAALSTNGNGFTTGTTQTVTVDVHHQLGGGGGGAAAAAKQLMANGISGHSRSTSLSHNIHAAAYSELSAAPPAFATPPTRRRFFNHKNLRSALTGGSGGGSGVGGGVGGAGGVGGGHRRTASNGGCPIDTASILSGDHTHQHHHRDNQPEGKESNALNTSTCSDSAVTRRRRKNVSNHNLKTSARHGASSENRLNRLSLAGTSVYAGHLSSLVFGKIKSLWSVNSSNSSEAGLNQLAGSDAIDHHSSFLNEKLQKDQLHARLGLLLNDPGSNGNSSSSGSGCEPISAHSTTSTTSSSGVGAASTTTSGSSQNVSPEQTLASGAGMLSGSQLSVATSHGVKEDALSLCGKFKAGCSMLHVYEALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAAVQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRVVLINGQPGTGKTAFCLQLVEYSCFGRRQMQDDPDGIYSQLQLGAHCERMRGLASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQMLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQNSQSGSQPQTKFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNICLAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTLLSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKLGPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQSGVLCEVVEVLKRIQTELLTRISISSEDQTGRMSNIGGGASVAYESHHEITDL
Protein: Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (RNase H(201)) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) (P53942)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribonuclease H2 subunit B
- Ribonuclease H2 subunit C
- Ribonuclease H
- DNA polymerase epsilon catalytic subunit A
- DNA topoisomerase 1
- Proliferating cell nuclear antigen
- ATP-dependent helicase SGS1
- DNA repair and recombination protein RAD52
- Flap endonuclease 1
- DNA primase small subunit
Sequence:
MVPPTVEASLESPYTKSYFSPVPSALLEQNDSPIIMGIDEAGRGPVLGPMVYAVAYSTQKYQDETIIPNYEFDDSKKLTDPIRRMLFSKIYQDNEELTQIGYATTCITPLDISRGMSKFPPTRNYNLNEQAHDVTMALIDGVIKQNVKLSHVYVDTVGPPASYQKKLEQRFPGVKFTVAKKADSLYCMVSVASVVAKVTRDILVESLKRDPDEILGSGYPSDPKTVAWLKRNQTSLMGWPANMVRFSWQTCQTLLDDASKNSIPIKWEEQYMDSRKNAAQKTKQLQLQMVAKPVRRKRLRTLDNWYR
Protein: Disulfide oxidoreductase (Q2GHG9)
Organism: Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Interaction partners:
- C-type cytochrome family protein
- Thioredoxin-like fold domain-containing protein
Sequence:
MLRILFLLSLVILVASFPLINNWLSSKSGKTIIDKDTIISIVEEYIANYPQKVIDLLTRGQAQAENEEMSKNIKKYKSELEDSSYPSAGNKDSKIVFVEFFDYSCGYCKMMSEDMKQIIQDGKVRVIFRDFPILGEASLKAVQAALAVHLINPSKYIEFYHAALNHKQQFNDESILSLVKSIGIAEEDFKVSLAKNSDTIEKMIQSTKELAQNINIRGTPAIIIGDTFIGGAADISTLRSKIDEQG
Protein: FAD-dependent oxidoreductase domain-containing protein 2 (Endoplasmic reticulum flavoprotein associated with degradation) (Q8IWF2)
Organism: Homo sapiens (Human)
Function: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:19706418}.
Interaction partners:
- Protein sel-1 homolog 1
- Protein OS-9
- Thioredoxin domain-containing protein 16
- DnaJ homolog subfamily C member 10
- Endoplasmic reticulum lectin 1
Sequence:
MGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQCSVLFVATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAFGKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHSVTWPATELPITQLTSSIVRRVNEASGLYQMFGVLADVILLKENSTAFEYLEEFPIQMLAQLETLTGRKAKHGLFVINMEYGRNFSGPDKDVFFDDRSVGHTEDAWQSNFLHPVIYYYRYLPTEQEVRFRPAHWPLPRPTAIHHIVEDFLTDWTAPIGHILPLRRFLENCLDTDLRSFYAESCFLFALTRQKLPPFCQQGYLRMQGLVSTESLWQHRVESRLLRDYAPTGRRLEDSSQQLGDQEPLGSPLAPGPLAQSVDSNKEEL
Protein: PsbP domain-containing protein 3, chloroplastic (OEC23-like protein 2) (Q9S720)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}.
Interaction partners:
- PsbP domain-containing protein 6, chloroplastic
- AT3g23700/MYM9_3
- PsbP domain-containing protein 5, chloroplastic
- PsbP domain-containing protein 7, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Tagatose-6-phosphate ketose/aldose isomerase, putative
- Uncharacterized protein At5g19190
- Peptide transporter family protein
- At5g43870)
- Photosynthetic NDH subunit of lumenal location 2, chloroplastic
Sequence:
MAAISPWLSSPQSFSNPRVTITDSRRCSSISAAISVLDSSNEEQHRISSRDHVGMKRRDVMLQIASSVFFLPLAISPAFAETNASEAFRVYTDETNKFEISIPQDWQVGQAEPNGFKSITAFYPQETSTSNVSIAITGLGPDFTRMESFGKVEAFAETLVSGLDRSWQKPVGVTAKLIDSRASKGFYYIEYTLQNPGEARKHLYSAIGMATNGWYNRLYTVTGQFTDEESAEQSSKIQKTVKSFRFI
Protein: Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a) (O35092)
Organism: Rattus norvegicus (Rat)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99595}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit TIM16
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM14
- DnaJ heat shock protein family
- GrpE protein homolog 1, mitochondrial
- Mitochondrial import receptor subunit TOM40 homolog
Sequence:
MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAFKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSTIDCGMVQIRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAEDHSQLPSSQLPSSPFGDYRQYQ
Protein: Translin (Component 3 of promoter of RISC) (Q71SY3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Translin-associated protein X
- Protein argonaute-2
- Endoribonuclease Dicer
- Protein argonaute-1
- Ribonuclease 3
- Protein argonaute-4
- Protein argonaute-3
- RISC-loading complex subunit TARBP2
- Interferon-inducible double-stranded RNA-dependent protein kinase activator A
- Ribonuclease P/MRP 38 subunit
Sequence:
MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK
Protein: Interleukin-21 (E4W7U2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLLVCYLLAITCVLVDADKGERILKLTEVIKELKALNRTVTHNSVMSNAPSMDTEECCSQSALKCFRAMVPHLKAKNKTLQRKVIKNLNNRMILGSLDSCSQEEREKTVCQGCDSYPKDSQKCVQQLESLLQKAISRLA
Protein: Protein YihD (P0ADP9)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Thiol:disulfide interchange protein DsbA
- Stress response kinase A
- Molybdopterin-guanine dinucleotide biosynthesis adapter protein
Sequence:
MKCKRLNEVIELLQPAWQKEPDLNLLQFLQKLAKESGFDGELADLTDDILIYHLKMRDSAKDAVIPGLQKDYEEDFKTALLRARGVIKE
Protein: Lipoate--protein ligase 2 (EC 6.3.1.20) (LplA2) (A0A0H3JX98)
Organism: Staphylococcus aureus (strain Mu50 / ATCC 700699)
Function: Catalyzes specifically the lipoylation of GcvH-L (SAV0324), likely via the ATP-dependent activation of lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domain of the target protein. Can also utilize lipoamide as substrate for GcvH-L modification.
Interaction partners:
Sequence:
MYLIEPIRNGEYITDGAIALAMQVYVNQHIFLDEDILFPYYCDPKVEIGRFQNTAIEVNQDYIDKHSIQVVRRDTGGGAVYVDKGAVNMCCILEQDTSIYGDFQRFYQPAIKALHTLGATDVIQSGRNDLTLNGKKVSGAAMTLMNNRIYGGYSLLLDVNYEAMDKVLKPNRKKIASKGIKSVRARVGHLREALDEKYRDITIEEFKNLMVTQILGIDDIKEAKRYELTDADWEAIDELADKKYKNWDWNYGKSPKYEYNRSERLSSGTVDITISVEQNRIADCRIYGDFFGQGDIKDVEEALQGTKMTREDLMHQLKQLDIVYYFGNVTVESLVEMILS