wanglab/gogpt-training-data huggingface dataset:
Protein: Protein Z-dependent protease inhibitor (PZ-dependent protease inhibitor) (PZI) (Regeneration-associated serpin 1) (RASP-1) (Serpin A10) (Q62975)
Organism: Rattus norvegicus (Rat)
Function: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Vitamin K-dependent protein Z
- Fibrinogen alpha chain
- Carboxypeptidase B2
- Epsilon 3 globin
Sequence:
MRVVSSLFLPVLLAEVWLVSSFNLSSHSPEAPIRLVSQDYENQTWEEYEWADPRDDNEYWLRASQQLSNETSSFGFSLLRKISMRHDGNVIFSPFGLSVAMVNLMLGAKGETKVQVENGLNLQALSQAGPLILPALFKRVKETFSSNKKLGLTQGSFAFIHKDFEIKKTYFNLSTMYFDTEYVPTNFRNSSQARGLMNHYINKETEGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPIFTEADTFHLDKYKAVKVPMMYREGNFASTFDKKFRCHILKLPYQGNATMLVVLMEKSGDHLALEDYLTTDLVEMWLQDMKTRKMEVFFPKFKLNQRYEMHELLKQVGIRRIFSTSADLSELSAVARNLQVSKVVQQSVLEVDERGTEVVSGTVSEITAYCMPPVIKVDRPFHFIIYEEMSQMLLFLGRVVNPTVL
Protein: Sarcoplasmic reticulum glycoprotein, putative (Q388B5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}.
Interaction partners:
Sequence:
MSSGNRDLSVDNPLQWRDLNNTEEFMRKLHEIYMKSVKPLEDIYLYEVLSPRWFEETLSSYKPIVTFLGPWSAGKSTFINYLLQDNYLFTGPQPTTSEFTVITYGDDVTTLDGHVVASTKDLPFRALANFGEGFMGNFCGLQVPHELLKRVVLVDTPGVLENSTDDRERRYNYTEVCRWFVERSDMVFLLFDPAKLDAGTELRNLFRYTFKGMEGKLRIVLNKADSVAKKELMRVYGSLFWNLSTLIRCTEPPRVYIGSFWDQPYKPGTFALLFTKEKEDLLYELTELVPRQARDRKVAALISHAKKVVCHAYIVGGIRADLPMFFGKEKAKRKALENLPKTYQLVASRNRLSPKDLPPAQLYHEYFEKVHLEKLPDIKKVEKTGMITTAQHYICNILPSMFYPMKQVPVPDPRNKTEQGKLREMYYGGLRDQYDGKEGKQGSSDTVPIAFRETALGPNPELRGGCGQLTVPGATANTTPAMNNVQMNEQQQQMLMQMMMMMQQQQQQGNNQFYAPR
Protein: Prolactin receptor (B4XS43)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
PEGKDLQDVGCLKSKSQSDNDSGRGSCDSHTLLMEKCGGVESKDESSYEEPELLQGQAGSWERLERGDSQVVDTPDSSDARVKTWPLVFSPSIHGSSDNHHYGTLEMPKQHSTSEITYSVPDHLFATSTSFPHHHHPEYRDSLGEYSEYRHSRSPSTGVLYHWEAQHHPQAHSNFNIRNLERQKEATGLGLPPSRSMEYVEVQKVNQENQLVLKPLSSHGRGPSQVQFGRAVVDYSKVNGVNNDNVLLLQRQREMAEAGQYCDYREKE
Protein: Ppp2r5d protein (Q499R1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
AERAECGRAEPEPERGRRSRAGCGPAEMPYKLKKDKEPPKLAKGTAKPSSSSKDGGGENTDTEAQPQPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
Protein: Ankyrin repeat-containing protein YAR1 (P46683)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for normal rate of cell proliferation.
Interaction partners:
- Small ribosomal subunit protein uS3
- Protein LTV1
- Pre-rRNA-processing protein TSR2
- Ribosome assembly protein RRB1
- Assembly chaperone of RPL4
- Synchronized import protein 1
- Ribosome assembly protein SQT1
- Protein BCP1
- 20S rRNA accumulation protein 4
- Essential nuclear protein 1
Sequence:
MGLHSEPLDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKFGHDAIFEAENSGKEEVETYFLKKYDVEPEDDEEDTQTEGKNSVQITKGTEIEQVTKEATEALREETEKLNINKD
Protein: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) (Q6DFZ1)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q92538}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q92538}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q92538}. Golgi apparatus {ECO:0000250|UniProtKB:Q92538}. Cytoplasm {ECO:0000250|UniProtKB:Q92538}. Lipid droplet {ECO:0000250|UniProtKB:Q92538}. Membrane; Peripheral membrane protein {ECO:0000305}. Note=Cycles rapidly on and off early Golgi membranes. Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (By similarity). {ECO:0000250|UniProtKB:Q92538}.
Interaction partners:
- ADP-ribosylation factor 1
- ADP-ribosylation factor 4
- Ras-related protein Rab-1A
- Ras-related protein Rab-1B
- ADP-ribosylation factor GTPase-activating protein 1
- Coatomer subunit gamma-1
- Coatomer subunit alpha
- Coatomer subunit gamma-2
- ADP-ribosylation factor 3
- Coatomer subunit beta
Sequence:
MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFSNLKEVLNSVTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNMKKLKMRAGGMSDSSKWKKQKRSPRPPRHTTKVTPGSELPTPNGATLPSNLTGGVPFIDAPTSISSASSEAASTVVSPCTDSGLELSSQTTSKEDLTDLEQAGSPREITTSEPGSSEMGASDQLDPQEGAHVEKAQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITVENPKMPYEMKEMALEAVVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTESHCQAKVLNTLNQQEKKETARPGFEAVDGNPETNKSERATSDGKSTGVALDARGLHFPSGGWLSTEHGKPGCRDLEEAGDSGADKKFTRKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGASPEGVFLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADMVNSGWLVVGKDDIDNSKPGAGLSRPGPSPLVNQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRSKSHKYDSKGNRFKKKPKEGSMLRRPRGSNQHATRGGHSDEEEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLEGGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPAEPHSQKPLASTHLTSAAGDPRMPGHPPLPEIPSEMGVCDSEKPESTRAPSSSSPGSPMASSPSKLSPAQEGPPPLTQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN
Protein: Integrin beta (W5UFK1)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
Interaction partners:
Sequence:
MPQAAKIVLLLLFGQYVYSQEKECIKSSVVSCKDCINSGPGCAWCQELNFTKTGEPEAVRCDTEEKLKEKGCSQQKIISPSSHLENIANKPLSGSDRTKNPVQVQPQEIKLNLRPGQAFTFNLQFKRAVGYPVDLYYLMDLSYSMEDDLTNVKDLGIQILKRLQQITGNARIGFGSFVDKTLLPFTDTTEEKLKKPCPAKAKQCQPAFGYHHVLSLTQNETLFSTMVSGQEISGNLDTPEGGLDAIMQVATCVNKIGWGNSTRLLVLATDAGFHMAGDGKLAGILEPNQETCQLDNKNIYSMSNNWDYPSVGQIARKLEEENIQPIFAVTEDVSHIYQELSKLIPKSEVGVLSSDSSNVVKLIVDAYNKLSSNIIVTHDGLPEDISVTFTSNCPGGEKPSDRGTCNNVAIGQVVTFSVTVKAAKCLDKAYFQIGPLGFSEKLKVNIKTRCECECDNQPGVQLYCNQHGTIVCGTCSCVPGFLGQRCECSLGQKDEATLKAQCRKDNGTECEGRGDCECGVCKCHQTEGGKSYYGPHCECDDEHCEKYQNKLCGGNGDCRCGVCKCNEGYEGTACQCKKSNEFCETGKTICHGRGKCVCNQCVCERRYKGITCETCPTCELPCQESGSCVECKAFGTGPFEKTCNASCYHLDVEVVEKLAKRECQVKDNEGCRMIFSMTEQDGFDKYIVKVLKDRECPEGPNVALIVGGSLAGVALIGLLLLILIKALFYFKDLKEWKKFEKEAQRRQWAKGENPLFQKATTTVANPAFTGDS
Protein: Transcriptional activator HAP5 (Q02516)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP5 is essential for DNA-binding activity. It may be the linchpin that binds to the subunit association domains (SAD) of HAP2 and HAP3 to bring these proteins together.
Subcellular location: Nucleus.
Interaction partners:
- Transcriptional activator HAP4
- Transcriptional activator HAP2
- Transcriptional activator HAP3
- DNA polymerase epsilon subunit D
- AP-1-like transcription factor YAP5
- Glycerol-3-phosphate dehydrogenase, mitochondrial
Sequence:
MTDRNFSPQQGQGPQESLPEGPQPSTMIQREEMNMPRQYSEQQQLQENEGEGENTRLPVSEEEFRMVQELQAIQAGHDQANLPPSGRGSLEGEDNGNSDGADGEMDEDDEEYDVFRNVGQGLVGHYKEIMIRYWQELINEIESTNEPGSEHQDDFKSHSLPFARIRKVMKTDEDVKMISAEAPIIFAKACEIFITELTMRAWCVAERNKRRTLQKADIAEALQKSDMFDFLIDVVPRRPLPQ
Protein: Meiotically up-regulated gene 123 protein (O74461)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in sporulation and has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 165 protein
- Meiotically up-regulated gene 168 protein
- Meiotically up-regulated gene 166 protein
- Uncharacterized membrane protein C16E9.09c
- Phospholipid-transporting ATPase neo1
- Uncharacterized protein C1739.04c
- Small ribosomal subunit protein eS28B
- Uncharacterized membrane protein C17A5.08
Sequence:
MERLATRSSHDDPYSRSSLPTSNAINSNHESNGSTFSYVQSLRRAKATVWSDIGRVAPLHSSPSIKSSSQNGKSSSKGLGGMRSRVFSSQHHGVYHTRPASLHSRTMAPQHTILTPRLSATEGKDDDEDELVISTSNTAPTYISMIESSRASSTHSGTAPSIMGMSIHSRADSRAETTQSDGFESRSGSPTHDIQSYLVNRRSSSSESSDEDSAEEGMKRLVITNMGDNDEFDSD
Protein: Peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) (O43832)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
AESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGARREDMKCFQCKEMISVQ
Protein: Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) (Q148J6)
Organism: Bos taurus (Bovine)
Function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P59998}. Cell projection {ECO:0000250|UniProtKB:P59998}. Nucleus {ECO:0000250|UniProtKB:P59998}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 2
- Actin nucleation-promoting factor WASL
- Actin-related protein 3
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1A
Sequence:
MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF
Protein: LD23309p (Scrambled, isoform A) (Scrambled, isoform B) (Q6NQZ5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDHNEISMTMDAKLDTHDKRPVALRYKTWTRCQVKIEAIKCVPCFLRLSFQAMETESHSQECHPAKPISVSVNVPGVSLSLATSRTKQHSYGLFWTQNRRDCFIYFALETETSCRRHMKWMRKSIKNLELYRQVFLEQRRLSRGPGGLGPLPNLPETLDASALSPRVSQIYEEIFDGSRISRVSIASGIYEEMKPSVMETPSPPPLPAHPYRQRINTFECAQLGEIARSSTNPESELAKKKKYKNMLDNLFGSSRQKRSGSTSEVANEPSDEVLPLYENAPTPEPVLPVKRTSQLNKSQRNSFSSPDLSKLNLLDTFGEYFEAQNHESSMEINISLDESVIEPISRNEIIAQISSQLGKADSLESLNVSEQLPYNFNFSACNTSTINLIGSHGAVPQSNQLKKNKILHEDLTGYCVMAPILKATVKDLPPQPGGSTVSTSSGYSTGSYCSSTSSCNTEDQPTKTQIANESDIYEVMHGTSLNSTVGAAAAGFAEHLYENLLAVKAAQELEAQPVGFGLSTSTPTESPLAPALPQKGTPKDKTLQQKPEEENYYQTPRKSIISVDDKIPSYYPNSCDTLKSKRRSPTEHGPSFRHLVSSKLRRERKENLYISSPQQIIEQRHKAATISSASVSAKTKSSTKKTAAHKISDSVYAVTHPVKRPNSTNSNNTHQSNNNNNNEGVDDELLHLTVLKNIDFKFDDSQASEDSCKAKASALPVANECFVQPNLEKEYEDRFQAAEKASRLLQKYATLAKIGHSPSKALPAPARLEPMIQSVATSNELQPEGGTMKKFASLPRFKKIDFSPLKMRLNSVLQRNPPSPQH
Protein: Glutathione S-transferase 2 (EC 2.5.1.18) (GST-II) (O59827)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the oxidative stress response and detoxification.
Interaction partners:
- Glutathione S-transferase 3
- Glutathione S-transferase 1
- Glutathione synthetase large chain
- Glutathione reductase
- Glutathione hydrolase proenzyme 2
- Glutathione hydrolase proenzyme 1
- Glutathione-specific gamma-glutamylcyclotransferase
- mRNA export factor elf1
- Uncharacterized oxidoreductase C663.08c
Sequence:
MAHFTLYSHAGGPNPWKVVLALKELNLSYEQIFYDFQKGEQKCKEHLALNPNGRVPTLVDHKNNDYTIWESDAILIYLADKYDTDRKISLSFDDPEYYKLIQYLFFQASGQGVIWGQAGWFNFFHHEPVVSAVTRYRNEIKRVLGVLEDILKDRDYLVANKYTIADLSFIPWNYNLGGLFGEGKFSFKEEVPQLDFEKEFPKAYAWNQRLLARPAVKATFEELAKAKEQH
Protein: Probable muscarinic acetylcholine receptor gar-1 (G-protein-linked acetylcholine receptor 1) (Q18007)
Organism: Caenorhabditis elegans
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Putative H/ACA ribonucleoprotein complex subunit 2-like protein
- Putative H/ACA ribonucleoprotein complex subunit 3
- G-protein coupled receptors family 1 profile domain-containing protein
- Probable H/ACA ribonucleoprotein complex subunit 1-like protein
- Putative H/ACA ribonucleoprotein complex subunit 4
Sequence:
MPNYTVPPDPADTSWDSPYSIPVQIVVWIIIIVLSLETIIGNAMVVMAYRIERNISKQVSNRYIVSLAISDLIIGIEGFPFFTVYVLNGDRWPLGWVACQTWLFLDYTLCLVSILTVLLITADRYLSVCHTAKYLKWQSPTKTQLLIVMSWLLPAIIFGIMIYGWQAMTGQSTSMSGAECSAPFLSNPYVNMGMYVAYYWTTLVAMLILYKGIHQAAKNLEKKAKAKERRHIALILSQRLGTQVGVSLMLQSKAEKEKAEEAQKDSGYTSNQAGDANNLRRFGFSEPETSQFRVDPNSNNNLNVEGSLNTENDQNLGVIEEERSGFLSRRESNESYYPGPHPTAANSRRCSEMEKVSLLSESDGVPSTRPAKSYGRLSLRSRYSASESITTTHENDEKEVEKADSLQKLFADDELGSVLNFKEEKLKNTDSNNDSDTTSVILQRSRKYKKNKRPRSSRRSEHSTPRQIAKVKQAEGTAAQLIEESVPDDDQTETIEVKRTDRWVVSMKKRIARALIRRRSTTRPERGSSSNSDDSSSEVEGEEKPEVRNNGLKIPQLTVNNENRGETSSQPGRDRLAPPNKTDTFLSASGVSRKISTISTVITREKVISSIFAPIAVFNRGRKQTKAEKRAHKAFRTITFIVGFFAILWSPYYIMATVYGFCKGECIPSFLYTLSYYMCYLNSSGNPFAYALANRQFRSAFMRMFRGNFNKVA
Protein: histidine kinase (EC 2.7.13.3) (Q9WZV7)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Interaction partners:
Sequence:
MEEIKEQNNRLFLLLSIMIMEFSNAKTESDILQGLLNLVRKVVDIKEVVLVDENKRKIWGRDIDIKRFEEFIDWSIRQSNPVFVEDELGYVGIVPVVKQDRMFGSLIVLLNHQPSMEETEIFKVLSFLSAVVLENIKLYRELEETYNYVNVILNGLPEGIFVYSNGEIKFQNEKFKEENFPDEVLRKAISLSEEAISLRTQRVGEVISGEEFFSITSIPLILGSEVQALTIVENVTESKELERLKRIDRMKTEFIANISHELRTPLTAIKAYAETIYNSLGELDLSTLKEFLEVIIDQSNHLENLLNELLDFSRLERKSLQINREKVDLCDLVESAVNAIKEFASSHNVNVLFESNVPCPVEAYIDPTRIRQVLLNLLNNGVKYSKKDAPDKYVKVILDEKDGGVLIIVEDNGIGIPDHAKDRIFEQFYRVDSSLTYEVPGTGLGLAITKEIVELHGGRIWVESEVGKGSRFFVWIPKDRAGEDNRQDN
Protein: Long chain acyl-CoA synthetase 9, chloroplastic (EC 6.2.1.3) (Q9CAP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate.
Subcellular location: Plastid, chloroplast envelope {ECO:0000269|PubMed:12177483}.
Interaction partners:
- Palmitoyl-acyl carrier protein thioesterase, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 2, chloroplastic
- Putative peroxisomal acyl-coenzyme A oxidase 1.2
- Peroxisomal acyl-coenzyme A oxidase 1
- Phospholipid:diacylglycerol acyltransferase 1
- Acyl-coenzyme A oxidase 2, peroxisomal
- Acyl-coenzyme A oxidase 3, peroxisomal
- Acyl-coenzyme A oxidase 4, peroxisomal
- Putative acyl-coenzyme A oxidase 3.2, peroxisomal
Sequence:
MIPYAAGVIVPLALTFLVQKSKKEKKRGVVVDVGGEPGYAIRNHRFTEPVSSHWEHISTLPELFEISCNAHSDRVFLGTRKLISREIETSEDGKTFEKLHLGDYEWLTFGKTLEAVCDFASGLVQIGHKTEERVAIFADTREEWFISLQGCFRRNVTVVTIYSSLGEEALCHSLNETEVTTVICGSKELKKLMDISQQLETVKRVICMDDEFPSDVNSNWMATSFTDVQKLGRENPVDPNFPLSADVAVIMYTSGSTGLPKGVMMTHGNVLATVSAVMTIVPDLGKRDIYMAYLPLAHILELAAESVMATIGSAIGYGSPLTLTDTSNKIKKGTKGDVTALKPTIMTAVPAILDRVRDGVRKKVDAKGGLSKKLFDFAYARRLSAINGSWFGAWGLEKLLWDVLVFRKIRAVLGGQIRYLLSGGAPLSGDTQRFINICVGAPIGQGYGLTETCAGGTFSEFEDTSVGRVGAPLPCSFVKLVDWAEGGYLTSDKPMPRGEIVIGGSNITLGYFKNEEKTKEVYKVDEKGMRWFYTGDIGRFHPDGCLEIIDRKKDIVKLQHGEYVSLGKVEAALSISPYVENIMVHADSFYSYCVALVVASQHTVEGWASKQGIDFANFEELCTKEQAVKEVYASLVKAAKQSRLEKFEIPAKIKLLASPWTPESGLVTAALKLKRDVIRREFSEDLTKLYA
Protein: Trehalase (EC 3.2.1.28) (Alpha-trehalose glucohydrolase) (G3V7Q9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Catalase
- Sucrase-isomaltase, intestinal
- Protein YIPF6
- Galactose mutarotase
- Protein-glucosylgalactosylhydroxylysine glucosidase
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- Hexokinase-3
- 1,4-alpha-glucan branching enzyme
Sequence:
MTWELHLLLLLGLGLSSQEALPPPCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIPREELQNFVQSYFQPVGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAEVLSHPERSSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRVYYLQRSHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYILNRYYVPYGGPRPESYSKDEELAKTVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWAGCFSDPSVADRALKYLEDNKILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLVTALLLSLLLQ
Protein: Cell division protein FtsZ (A0A0H2ZNE0)
Organism: Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909, ECO:0000269|PubMed:34373624}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. Localizes at newly formed division sites. Colocalizes with CcrZ during the full cell cycle (PubMed:34373624). {ECO:0000255|HAMAP-Rule:MF_00909, ECO:0000269|PubMed:34373624}.
Interaction partners:
Sequence:
MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAANTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFITAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVDTLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTVMANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEAEEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARSATNYRETVKPAHSHGFDRHFDMAETVELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSVVSPVERFEAPISQDEDELDTPPFFKNR
Protein: Pleiotropic regulator 1 (Q922V4)
Organism: Mus musculus (Mouse)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43660}. Nucleus speckle {ECO:0000250|UniProtKB:O43660}.
Interaction partners:
- Cell division cycle 5-like protein
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor SPF27
- Pre-mRNA-processing-splicing factor 8
- Pre-mRNA-splicing factor SYF1
- Crooked neck-like protein 1
- 116 kDa U5 small nuclear ribonucleoprotein component
- Spliceosome-associated protein CWC15 homolog
- SNW domain-containing protein 1
- Pre-mRNA-splicing factor RBM22
Sequence:
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYPHKQYPANQGQDVEYLVTGTHPYPAGPGVALTADTKIQRMPSESAAQSLAVALPSQTRVDANRTGPAGSEYRHPGASDRSQPTAMNSIMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTLDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLLYTFASGSPDNIKQWKFPDGGFIQNLSGHNAIINTLAVNADGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDRSESRLLTAEADKTIKVYREDETATEETHPVSWKPEIIKRKRF
Protein: UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (EPT) (UDP-N-acetylglucosamine enolpyruvyl transferase) (A0A0H2ZNL3)
Organism: Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity). Target for the antibiotic fosfomycin. Involved in heteroresistance to antibiotic fosfomycin. Heteroresistance is the ability of a clonal population to grow one or several subpopulations at a frequency of 10(-7) to 10(-3) in the presence of a higher antibiotic concentration than that predicted to be effective by measurement of the minimum inhibitory concentration (MIC).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00111}.
Interaction partners:
Sequence:
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGYSDIIEKLRNLGADIRLVED
Protein: Protein DSS4 (P32601)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Guanine-nucleotide-releasing protein that acts on SEC4. Might play a general role in vesicular transport.
Interaction partners:
- Ras-related protein SEC4
- GTP-binding protein YPT1
- Cell division control protein 42
- Translation initiation factor eIF2B subunit epsilon
- Cell division control protein 24
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit gamma
- Rab guanine nucleotide exchange factor SEC2
Sequence:
MSKATCSFEGCHSAVITINDDNIINLPEQVHSEFKLLENRTMRDATPSESNFLVVPDVWDFDNVGVSREIPSSILGDLSDKSDFVFEYGNSSWKIKKCLKYLICADCDKGPIGIICKVQDQTKNEERVLHLLSLRSLQIMGRN
Protein: WD repeat domain 36 (WD repeat-containing protein 36) (A3KPR1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Nucleolar protein 56
- IMP U3 small nucleolar ribonucleoprotein 4)
- Something about silencing protein 10
- WD repeat domain 43.
- U3 small nucleolar ribonucleoprotein protein MPP10
- Bystin-like.
- HEAT repeat-containing protein 1
- PWP2 small subunit processome component.
- Nucleolar protein 58
- UTP6 small subunit processome component.
Sequence:
MSSMSANKKGSVIFSGFRALGLYSNHLAHVVRFHKKHREFYVVTAVGQCFHTYNVKKLGIVAVSNALPEDISSVTADCMLVYAAYGKLISAFARSREVVHTYTGHQADVHLLLPFGNHLISVDKDNVVIIWDVESEDTYLQISYDKASFEVSALMHPSTYLNKILFGSSQGSLQLWNIKSNKLLFTFSGWSAAVTVLQQTPAVDVVGVGLASGQIIIHNIKFDETLMKFQQDWGPITALSFRTDGHPIMASGSPIGHIGLWDLEEKKLVSQMRDAHTTAIAGLTFLQNEPLLITNGADNAIRVWIFDVAGGDGRLLRQRMGHSAPPTKIRHYDQSGLNILSAGQDGTLQSFSTVHERFNKSLGHGTLNKAKAKKKGVKYDTAKLPSITTFASETARQSDWDGIIACHRGFLMTTSWNYQKGSMGAHKLEPERFNRNRSLNVHATAVDISSCGNFAVIALSSGHIDVYNMQSGLHRGHYGEDKAHEGPVRGVAVDALNQLTFSVGADHLLKIWKFKSKEHLHTHRLPAAPASSLLHRDSGMLAIALDVFAIHILDVETRRIVRKFSGHRGQINDMTFSPDGRWLITASMDCTIRTWDLPSGSLVDCFLVEAAAVSVSLSPTGNFLASSHVDGLGVYLWSNNTLCSLVSLRPLPADYEPTVIMLPGNCPSKDTEEEEVLDSDSSEMAEYISPAQLDEHLVTLSLLPDSRWKNLLHLDIIKKKNKPKEPPKVPKAAPFFIPTIPGLVPQFSLPNTPSEAQSKVVNLGVLAQKSNFYIELENAIESNSYEEPVKLLRELGPSAIETELRALSPDMGGDVGVMKSFLKMISCILKSKKDFDLAQAYLALFLKLHLRLISDEPELMEEAERVSAQLEETWMCIQTLLNQSICLLSYIKSALL