wanglab/gogpt-training-data huggingface dataset:
Protein: Trehalose-phosphatase (Q5AI14)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Alpha,alpha-trehalose-phosphate synthase
- Trehalose 6-phosphate synthase/phosphatase complex subunit
- Glycogen [starch] synthase
- Trehalase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogenin glucosyltransferase
- glycogenin glucosyltransferase
- 1,3-beta-glucan synthase
- 1,3-beta-glucan synthase
- 1,3-beta-glucan synthase
Sequence:
MAPQQVNAFSANGSIPSPKEFEGKGKLKLSGRILNVMTSLPLQIISDYDNKTGQYYWDVETVRGNSALYSSQHFLAENKEWETHLIAWTGELINKKKDTSSLTADTLQDDPLYLDEEDKSKIEKKLCDASGTPNIHPVWLLRRDQGRWRKYAENVLWPVFHYIQGQPSDGKAETDAWHDYVKFNEAYLNKIKSVYKPGDIIWIHDYYLLLLPQLLRMEFPNAYIGFFLHVPFPSSEYFRCLSKRSQLLDGMLGADKIGFQSDSFQRHFISCCARVLGCEVNRDSVSAYGTTISVETLPIGIDTEKIEHDAFSSELGVEEKVQALKQVYKGKKLIVGRDRLDKVRGVIQKLEGFEIFLDMYPEWRETVVLIQVSSPGYSHSANVETRVTEIISRINSKYGNLNHTPVLHYQMRVAKEEYLALLRVADLALITSVRDGMNTTSLEFVICQKYNNSPLILSEFTGTATVLKDAIMVNPWDSVGVAKTINDALMLSTKEKVSLESKLYEKVLSNTVQNWTSTFICDILSHSIVTHSNSYTPALNRPLLLNNYKESQRRLFLFDYDGTLTPIVQDPAAAIPSDKLNRILDVLSSDPKNQIWIISGRDQAFLEKWMGNKNVGLSAEHGCFMKDIGSKEWVNLAASFDMSWQEKVDDIFKYYTEKTPGSNIERKKVALTWHYRRADPDLGNFQAEKCMKELNDTVAKEYDVEVMAGKANIEVRPKFVNKGEIVKRLVLHPHGAKQEKHPTGHCTKDIPIEELPDFMLCLGDDLTDEDMFNSLNEINKKWKGDNRPTNKFGSYGVYPVAVGPASKKTVAIAHLNEPRQVLETLGLLAGLVSIFESAGTVDLDDRGHLANSVSSERSKHAVSKAVSLRKKASQEKEIVKEDPTNGAK
Protein: Uncharacterized protein (Q54ST5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004125}.
Interaction partners:
- Small nuclear ribonucleoprotein E
Sequence:
MKKLNVQEQKETDKLFATSTDALKSLYSSKIKPLEQLTKFGDFFSPTLTDADIAAKPMILLLGQYSTGKTSFINYLLEKPFVGSNVAVEPSTDRFNAVMHGTDDRILPGNIVCVQSQDFPFKGLEKFGNGFMGRFQCSLSNAPILEKVSFIDTPGVLNIITHGGNEGKKVGRSYDFPQIVEWFAERSDMILLLFDAHKLDISDEYREAITKLKGHDEKIRIVLNKADNINAQQLLRVYGGLMWSLGRVITTPEVKKVTIGSFWSGPLQNKETENLLYSEMVDLIKDILLLPKNGAIRKVNDLVKRSRLVKVHALILNHLRSEMPVFGKEKKQAELIANLDKEFQKISLISRIPMGDFPDVDHYRTVLKVHDFTKFPKINEKMLAQLNEVLAVDFPNLLSRFPIDGTHKPSAYELNPFALDEVDENVRWTLFENVDISAFAPLFNSLNPMDGKIQGQVAKGPLFQSGLPNNVLAHIWRLSDVDRDGKMDIEEFALAMHLVNVKLKGYELPETLPTTLIPFSKRGGMFGSNPNSSSYQTILSQPQQQQQQYQQQFINNYEQQQQQQQQQQ
Protein: Rik1-associated factor 2 (Cryptic loci regulator 7) (De-localization of swi6 protein 2) (O74560)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Clr4 methyltransferase complex (ClrC) which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me. ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity for the methylation of H3K9. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Mitochondrion {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16040243, ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18345014}. Chromosome {ECO:0000269|PubMed:16040243, ECO:0000269|PubMed:18345014}.
Interaction partners:
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- Cullin-4
- Rik1-associated factor 1
- Chromatin modification-related protein rik1
- RING-box protein pip1
- DNA damage-binding protein 1
- Meiotic chromosome segregation protein P8B7.28c
- DNA repair/transcription protein mms19
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit hcn1
Sequence:
MPPVRAEKKRKTDLIEQVCVTNKAGELVDLEDVLEYGPYSLTGILSSEKDEQEPLFDESIVLGYSIKISPVWTYNLKDVPEKETMSIWIVTPQRRYGILSPSSEYKAIYEQISEKNRLFYLIKTKFKDDMISGTLEDYDNYIEVLKEKLELPSCFQAILLVQKHIRFLLTQMVATSSLHVWSESPFFIRIRSSYEHLILQINKNIYNARQERKKSKLSSNNPSDNNTTMKSSLNQALTLINLPEQPFSISSPTATPQLGVVKRTSPLRFPLNDIWLSGLRIVDPNIESISLWKRIQVSTSPKHQRYISLQEVCSVIAQQLQITNLEALNKLSSHGETLLQIMHTAFTWRGTKLFNDIKHAIGFRSSVQQARSQFRGYCYDYLFMHCNNGEKTSLHLLRTLICMKLDFSNAQLAAKILFHFLLFDIGSGLSGSDYTYEQYINHSAVAFSFTEEIFEKNFVTVLPDFVKLFSISFGYWPAFSFYDELLKLLRNKYPKVYSSTPNLCDQVWLDRTNLFPCNRSTRSTLPYRPTKLLDLASASSCLSKKETDFKQDTGLYSYNLEKVEALKVSPDLQTGIWSCPVQNCLYFAVCDNPYKPSQVIYDHLLGHVDSKFIFKTPSNSVRSFTNKLEHIMYNIN
Protein: Protein FAM151B (Q6UXP7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASAGGPGSWSENILEYFLRNSQITAEDGAEITWYHAANHKAQTNEALKSTAHMIEADVLLPSDGSEHSQPIMAHPPETNSDNTLQEWLTEVMKSNKGIKLDFKSLAVVEPSMMLLENVKRHLKRPVWINADILPGPNGNSKVIDAKPFLDTVISFFPDVTFSLGWTTGWHPEKVNEGYSWTMVKEMEYICNELSQPVTFPVRAALVRQSCSQLLWLLKKSNRYSLTIWTGKNDNYSVEDLLYIRDHFDKKQVFYDILEPQNHEFKQAIGIKVNL
Protein: Shikimate dehydrogenase (NADP(+)) (SD) (SDH) (EC 1.1.1.25) (O67049)
Organism: Aquifex aeolicus (strain VF5)
Function: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Interaction partners:
- Shikimate kinase
- 3-phosphoshikimate 1-carboxyvinyltransferase
- 3-dehydroquinate dehydratase
- Chorismate synthase
- GMP synthase
- Probable nicotinate-nucleotide adenylyltransferase
- Anthranilate synthase component 1
- Phosphoenolpyruvate synthase
- DUF3467 domain-containing protein
- tRNA-specific adenosine deaminase
Sequence:
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRDLRG
Protein: Meiotic recombination protein rec24 (Meiotically up-regulated gene 6 protein) (Q9UUJ4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for correct meiotic chromosome segregation and recombination.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotic recombination protein rec7
- Meiotic recombination protein rec15
- Mei4-dependent protein 2
- Meiotic recombination protein rec6
- Linear element protein rec10
- Meiotic recombination protein rec12
- Meiotic recombination protein rec14
- Linear element protein rec25
- Linear element protein rec27
- Linear element protein Mug20
Sequence:
MNGTNTEDNSKQILIQTMYTYDSSGETLKIAIAWKIILKKPKGKNIKDYIEALRKGIEDQEHCEKYASTLLEPRPKTKKDVVLKNSNVTECVALKAKPFSKKIEDMDIFLLTNVHENLQEKRQTSGSLAHLDIEYTFNGLFRFLKCTADIKLKQTKVYEGADFLRIKTLFEEIFMFLKRDCKSPLVLTRLVELGDYVLDLIIITQSIMQNNANNGTGVISRAKFLEFYVFLEQLIFNKLSFASVEQLEKLLDQIVKRMKICFTYCKNDNPSIRLLYSECFFSYAEIYFPCLHSFDAQLSSAASKCVQILRDIITNEELQTDKQELSKSAYSAPSILLIGLKDMLFPEDIS
Protein: PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) (Q95RC8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine/threonine-protein kinase ATM
- Mutagen-sensitive 101
- SD25546p
- DNA repair protein Rad51 homolog
- Structural maintenance of chromosomes protein
- Nibrin
- Rad17
- Structural maintenance of chromosomes protein 5
- RecQ-like DNA helicase Blm
- Structural maintenance of chromosomes protein
Sequence:
MADVSLFFGGLPAILLKADTIYRIGRQKGLEISIADESMELAHATACILRRGVVRLAALVGKIFVNDQEETVVDIGMENAVAGKVKLRFGNVEARLEFGEDHDEVHDSSGFGECLKNGLNNTTLDSMDVPETQPPSANTSVNTTADSLFIPETQAVLCERPSTGQRVSLGDDFMIPETQDMLADLPPEPPVFKPPVIPVVDKPGPTIDSDEESSQGSIIRMCTQDYNEDAIDDFDTSQVLCDVLLPLPPPTAPIEGLENQDTKRDQLDTTDMEMSALNWSASNSKCCALSSTKADDILPRGDACITPDLTAPSVDRNICTPDLFDLIMGGDRRRDGSSSPDPFVRPADNTNTATPQFGGVKQLVVATIETPTATPDTNSQEKNQDMIATQRFPRHKLLESDEEDNGQNNQDFVATQAFNLGRPQAPQENEANQDLIATQAFNLAPPQKVDSPKPSTANDASNQDFIETQAFNLGIPQANMASPENNEISNQDLIATQAFPAKINSSRCQDFVATQPFHVVNQHSVSLQDKENIPLDDSVKVASDSKFFEATCGEIDAVLNEMISGTVATSPVSPNEESIPFFEPCVIKDKNHYQKICQIEGVFSNVSNRSRGRTDGTGFGRLKRVAKSESPPETPIRKDRRRSEGSERPGSNSRERLNNLVDKKSEALNKSVIREHGIDSIPEEITKEDKSDSEEKGDCFNNVVNQWRSRKRRIQSRPGTPGSSSERNEVNADVVDKPNEEPPTKNIRARKAKKAEKADSSKDIPKPTTRTRRQTSDEDVRTPDLGKGRKAKNTASSKADTSKNIAKGSKRVTRQNSADDAELLEEDSSVQTESGKRVKKVKSSKGETSKDIPKAKPRTRRQTADEDAMTPKAEKERQIQGEETKDMSKPAARTRRKASAEETESAAQAVKPKRGGKGKKNETTKAEATVEKPMVRTRRMTIAEDSSTLTEVKTGGALIKRAVVRISRVSIEQLESSTSAGNNARVTGAAQSRSTTPSIEEPSSSSAAAKEPNVSTATTRRRAKRLTSGEEPTSSSDVPTKKPKMSVDEEVLKNRSGATTTRFSQPDADPLRAINLYVRKAKTTTGKIKVAFTMCNRPALETVLKSLKHVVEITEDPLQCDLLVMDKGERTYKFLTVIASNKPVLSTNWLHSVKKTRSIDIKADHLFSDPTFEETYKFKPSSVLEHPRLLYGLHFMLGKDIVPKANEMKVIIHSAGGKVHAQPPSLAISVDLYVVTTSKDTKSKRRLNNYEKVHFIKTEAVMQALVQHNIEMLQEHTLKL
Protein: Cruzioseptin-12 (CZS-12) (A0A193H397)
Organism: Cruziohyla calcarifer (Splendid leaf frog) (Agalychnis calcarifer)
Function: Has antimicrobial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:27321580}.
Interaction partners:
Sequence:
MAFLKKSLFLVLFLGLVSLSICEEEKREEENEEVQEDDDQSEEKRGFLDVVKHVGKAVGKAALNAVNDLVNQGEQ
Protein: Cell wall protein IFF4 (Adhesin-like protein IFF4) (Q5AAL9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence. Plays a role in adherence to plastic and to host epithelial cells. Promotes the tissue fungal burden during murine vaginal candidiasis. Increases also susceptibility to neutrophil-mediated killing. Furthermore, contributes to the severity of hematogenously disseminated candidiasis in normal mice, but not in neutropenic mice.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:21841123}. Membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Predicted GPI-anchored protein 26
- Probable circularly permuted 1,3-beta-glucanase PGA52
- GPI-anchored hemophore PGA7
- Cell wall protein 1
Sequence:
MKFLQKFIITVALLTNIVFAIDITENKVDRGSVTLSFGEIIIHPGASWSIIDNAFSNFIGKLDVKAKSALYISSTSHLLALQVSLTTLLHSINNSGIISFDSRVSLTPSSYDLRGLSFTNSGEMYFAASGRVPSTMSLTSASWTNTGLLSFYQNQRTSGAVCLGFPLGSITNSGKICLNNQVYQQTTQIKGSGCFSANGDSTIYIANVLLSVSANQNFHLVDKDSSMIVQAISTTQTFNVYGFGNGNKIGLTLPLIGIILESAHSYDSSTGILTLRNFLLEQRFNIGLGYDSSKFSVVTDSGSGIPSTIWGSVTYTGRVPTRALPKSCQMACKPIPEAPGVKPTDYTTTITKTNTAGNTVTETGAVTISTDKSGSWFTTTSIFPTLTTATSTSITTTLSNEAHIKTTDNTLAKVSSTVDYISAPISSSEFISLESFVDETLSNENPISTSTDYASENSFAISESTFITASDFQATESLVTESYFSKSQSSDSESFVINTSSAVDNSYVSSSSSAGGSSFPEETHMLQTSDSDLSSTAGSESDVTEFSDVSLATASDSSIADKSIGTESLYSEISLVSASESTGSIGELSISGDTLLKTASETKFVKSSFSSDLISETSSELFVSSSVSTDMILETANDSFITSDKVVETPSYSNELAFETVSETIINSFVSSESSLNTASNSLIASKPSTDSSSYTTDIDFETTTKSFAESPSYFSETVSEIASKSSLSMVEPSCWSELPFETSIESLIAPSYISSEPAPETASESFIVKPSYSEIASESITKSIISTIEASISSDIFSDATTGSIVVQPSVSSGISLEIPSESMLFSESSISKPFISSQSIHECTSDSILVVPSFFSSDVSFETVEYSSTVSTSVDAEPSYSSEISLKTPSESFIVSETFLEPSYSGEVVLATPSESVVASETDVNKPSYSNEAVLQTPSESYILSETGVKESSESSEFALSTPSTSFIASETFTVQSFASSEVSFGSDRESTISTEAIQVEPSISNDVVLETASESFISKAPTTSEFTILSETSIVEPSILSDLRFETTSQSTEMAPSATGVSYFSSTETPLASSSSYESSFATSSVSAIQSINSQVASASFVSADSTDSSEVGSSYTTASAFGPASSASEEKFISVWETSNSGGSFTLESSTSVASVVTTPLPFTSNDIITEISSTWNGAKSDSPHTSESDITSQYNSHSTSVATRSDSISLTDTFEIGFASTWTTGGSGNGGSMKSDVSNQDSYATMLPTSFLDTSNSDITTGVVSTWDAKNSNSYTSAELSTDPYSSDGYASSATAALSITESIPTTDTINTEYHSNGDITTSGGFKEISLTSHYEGGFTSESAGYTIASPSGSTQEFATATITSCFESKCSENVVTYISSVSHSTVTTGYEDTRFTGSIFSGDLASTGDNIVSASGRSVTDATNPFATNTDIGTTSTVSLYGDLNDSDSSVSGYPTNRSDSNGYANTPTTGSNTSGDFSQTIETGSSSFTAIPFENGSTNISNKYLKFLGTVVSILILLI
Protein: Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) (Q22056)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03046}.
Interaction partners:
- Probable 26S proteasome complex subunit dss-1
Sequence:
MNDDLIMRKKPEQIEMEFQDSGESALVKSTLLSSLQNSEWEIAVRKEVKKFLEKARDDVSAKEVFDAVKDMARREIPQEAKKKLYDQVLEFVTTTNKK
Protein: Small ribosomal subunit protein uS19c (30S ribosomal protein S19, chloroplastic) (P12153)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS11c
- Small ribosomal subunit protein uS14c
- Os08g0513300 protein
- 30S ribosomal protein S13, putative, expressed
- Os02g0102400 protein
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein bS18c
- Small ribosomal subunit protein bS18c
- Large ribosomal subunit protein uL5c
- Small ribosomal subunit protein uS2c
Sequence:
MTRKKTNPFVAHHLLAKIEKVNMKEEKETIVTWSRASSILPAMVGHTIAIHNGKEHIPIYITNPMVGRKLGEFVPTRHFTSYESARKDTKSRR
Protein: SET domain-containing protein (Q584A8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGGVSPEVAAQAAARREAAAQLGSWRDMLLTLSKEFPPGSGLKPVEETLKYLREAEDKAGVVNALKSLEAGVSHACNVNDTDALEWKSRGNDAYSCKKLEECILMYTRGMMSASEDDTLAALINNRSAAFMAQGRITEALADAHAAFTLTPSYWKALQRRGSCLQRLGFIEEGTKDMEAASREEASGANGEEVVKKILHAGRSDGCCDGSSGNVVCGNATVVSGSANISYGTGVSGVVAKGPLDPGDIIREVPVAYALYDDHWGVRCCFCLKATRLLYSGAAYRSRGKSARGLFCSEVCAATSWERDGQYETTNAFFHLCPVDALVACRMLRSEQVLRGEELPLRSNFTGELYPAAVIGGYETAVSLLALVLGAADADGADRLRLAQRQVTLSAFELKFHTGTQININTETREALIDESRTIPVGKAVYVTAARFRHSCQPNCFASFVGNPLGCSLQLCIRAIRSVQAGEELTIAYHNMTKYKAVSAHTRRRSLVERCGFLCECSACRDDKDESVTSEKKAYYIQASDLYQKGCRLIREGQFETAVNVLSQSYALTMEHLCPPPRPPQTMVPKVHMALAKAFNRLRDDGKCVEHLVKKVELDNTLYGTDHVEMADDFIRLAFFEATEEKRRKSAERAVELLRRFYAQSRELDEQTRRIESFVTRSSPCQRAL
Protein: Inner membrane protein YcfT (P75955)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YjbG
- Protein CbrA
- Uncharacterized transporter YfdV
- Putative lipopolysaccharide heptosyltransferase 4
- Uncharacterized lipoprotein YjbH
- O-antigen ligase
Sequence:
MKQKELWINQIKGLCICLVVIYHSVITFYPHLTTFQHPLSEVLSKCWIYFNLYLAPFRMPVFFFISGYLIRRYIDSVPWGNCLDKRIWNIFWVLALWGVVQWLALSALNQWLAPERDLSNASNAAYADSTGEFLHGMITASTSLWYLYALIVYFVVCKIFSRLALPLFALFVLLSVAVNFVPTPWWGMNSVIRNLPYYSLGAWFGATIMTCVKEVPLRRHLLMASLLTVLAVGAWLFTISLLLSLVSIVVIMKLFYQYEQRFGMRSTSLLNVIGSNTIAIYTTHRILVEIFSLTLLAQMNAARWSPQVELTLLLVYPFVSLFICTVAGLLVRKLSQRAFSDLLFSPPSLPAAVSYSR
Protein: Mitofusin-2 (EC 3.6.5.-) (Hypertension-related protein 1) (Mitochondrial assembly regulatory factor) (HSG protein) (Transmembrane GTPase MFN2) (Q80U63)
Organism: Mus musculus (Mouse)
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O95140}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95140}. Note=Colocalizes with BAX during apoptosis. {ECO:0000250|UniProtKB:O95140}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Mitofusin-1
- Serine/threonine-protein kinase PINK1, mitochondrial
- E3 ubiquitin-protein ligase MARCHF5
- Dynamin-like GTPase OPA1, mitochondrial
- Mitochondrial fission 1 protein
- Mitochondrial antiviral-signaling protein
- Non-selective voltage-gated ion channel VDAC1
- Mitochondrial Rho GTPase 2
- Mitochondrial Rho GTPase 1
Sequence:
MSLLFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESASFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSMVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERQFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNLSDRCSTAIASSLQTMQQDMIDGLKPLLPVSMRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALLGYSDQVQRPLPLTPANPSMPPLPQSSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSRAKLLRNKAGWLDSELNMFTHQYLQPSR
Protein: DNA-directed RNA polymerase subunit Rpo5 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit H) (B8YB60)
Organism: Saccharolobus shibatae (strain ATCC 51178 / DSM 5389 / JCM 8931 / NBRC 15437 / B12) (Sulfolobus shibatae)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00025, ECO:0000269|PubMed:22848102}.
Interaction partners:
Sequence:
MRGSSNRKIDPRIHYLVPKHEVLSIDEAYKILKELGIRPEQLPWIRASDPVARSINAKPGDIIRIIRKSQLYGEVVSYRYVISG
Protein: BLOC-1-related complex subunit 7 (Diaskedin) (Q96B45)
Organism: Homo sapiens (Human)
Function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular location: Lysosome membrane {ECO:0000305|PubMed:25898167}.
Interaction partners:
- SNARE-associated protein Snapin
- BLOC-1-related complex subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- BLOC-1-related complex subunit 5
- BLOC-1-related complex subunit 8
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- KxDL motif-containing protein 1
- Arsenite methyltransferase methyltransferase)
Sequence:
MMATGTPESQARFGQSVKGLLTEKVTTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSDLQDQLNHLLK
Protein: Saposin B-type domain-containing protein (Q19837)
Organism: Caenorhabditis elegans
Interaction partners:
- Activin_recp domain-containing protein
- F-box domain-containing protein
- C-type lectin domain-containing protein
- Lysozyme-like protein 1
- glutathione transferase
Sequence:
MKTSALAFLALVCASSAFVVPQNADQCGAVDITKMAKRYVPSQNSDATCEICLDLVLIAETYAECDEAIVQHHMDAYCVEHVKNHASQALCKLLIDDIAHAVIEDTDQNPTGVCQKVIHKTCPYNN
Protein: Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1) (Q15835)
Organism: Homo sapiens (Human)
Function: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q9WVL4}.
Interaction partners:
- Rhodopsin
- Recoverin
- S-arrestin
- Neuronal calcium sensor 1
- Beta-arrestin-1
- Beta-arrestin-2
- Rhodopsin kinase GRK7
- MAGUK p55 subfamily member 4
- Calmodulin-like protein 5
- Calmodulin-like protein 3
Sequence:
MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDDMKGISGGSSSSSKSGMCLVS
Protein: Homeobox protein knotted-1-like 6 (Homeobox protein OSH1) (Homeobox protein knotted-1-like 1) (Oskn1) (P46609)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that regulates genes involved in development. May be involved in shoot formation during embryogenesis. Overexpression in transgenic plants causes altered leaf morphology. Regulates anther dehiscence via direct repression of the auxin biosynthetic gene YUCCA4. Binds to the DNA sequence 5'-TGAC-3' in the promoter of the YUCCA4 gene and represses its activity during anther development. Reduction of auxin levels at late stage of anther development, after meiosis of microspore mother cells, is necessary for normal anther dehiscence and seed setting.
Subcellular location: Nucleus {ECO:0000269|PubMed:29915329}. Cytoplasm {ECO:0000269|PubMed:29915329}. Note=Localizes mainly in the nucleus (PubMed:29915329). Translocation from the cytoplasm to the nucleus is facilitated by FTIP7 (PubMed:29915329). {ECO:0000269|PubMed:29915329}.
Interaction partners:
Sequence:
MEEISHHFGVVGASGVHGGHQHQHHHHPWGSSLSAIVAPPPPPQLQQQQTQAGGMAHTPLTLNTAAAAVGNPVLQLANGSLLDACGKAKEASASASYAADVEAIKAKIISHPHYSSLLAAYLDCQKVGAPPEVAARLTAVAQDLELRQRTALGVLGAATEPELDQFMEAYHEMLVKYREELTRPLQEAMEFLRRVETQLNTLSISGRSLRNILSSGSSEEDQEGSGGETELPEIDAHGVDQELKHHLLKKYSGYLSSLKQELSKKKKKGKLPKDARQQLLNWWELHYKWPYPSESQKVALAESTGLDLKQINNWFINQRKRHWKPSDEMQFVMMDGYHPTNAAAFYMDGHFINDGGLYRLG
Protein: Diol dehydratase-reactivating factor large subunit (DDR large subunit) (Diol dehydratase-reactivase large subunit) (Diol dehydratase-reactivating factor alpha subunit) (DDR alpha subunit) (DDRA) (O68195)
Organism: Klebsiella michiganensis (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686 / BUCSAV 143 / CCM 1901)
Function: Large subunit of the diol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent diol dehydratase (DD, pddA, pddB, pddC). DDR acts as a chaperone, reactivating inactivated DD holoenzyme in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one. Reactivation takes place in two steps: ADP-dependent cobalamin release, then ATP-dependent dissociation of the DD apoenzyme-DDR complex. DDR has weak ATPase activity which is required for DD reactivation. This subunit contains the adenosine nucleotide binding site. Activates glycerol-inactivated, O2-inactivated holoenzyme and inactivated enzyme-cyanocobalamin complex. Also reactivates glycerol-inactivated hologlycerol dehydratase, a DD isozyme.
Interaction partners:
Sequence:
MRYIAGIDIGNSSTEVALATLDEAGALTITHSALAETTGIKGTLRNVFGIQEALALVARGAGIAVSDISLIRINEATPVIGDVAMETITETIITESTMIGHNPKTPGGAGLGTGITITPQELLTRPADAPYILVVSSAFDFADIASVINASLRAGYQITGVILQRDDGVLVSNRLEKPLPIVDEVLYIDRIPLGMLAAIEVAVPGKVIETLSNPYGIATVFNLSPEETKNIVPMARALIGNRSAVVVKTPSGDVKARAIPAGNLELLAQGRSVRVDVAAGAEAIMKAVDGCGRLDNVTGESGTNIGGMLEHVRQTMAELTNKPSSEIFIQDLLAVDTSVPVSVTGGLAGEFSLEQAVGIASMVKSDRLQMAMIAREIEQKLNIDVQIGGAEAEAAILGALTTPGTTRPLAILDLGAGSTDASIINPKGDIIATHLAGAGDMVTMIIARELGLEDRYLAEEIKKYPLAKVESLFHLRHEDGSVQFFSTPLPPAVFARVCVVKADELVPLPGDLALEKVRAIRRSAKERVFVTNALRALRQVSPTGNIRDIPFVVLVGGSSLDFEVPQLVTDALAHYRLVAGRGNIRGSEGPRNAVATGLILSWHKEFAHER