wanglab/gogpt-training-data huggingface dataset:
Protein: CTD kinase subunit beta (CTDK-I subunit beta) (CTD kinase subunit 2) (Latrunculin sensitive cyclin knockout protein 1) (O59748)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. As part of the CTDK-I complex, involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing. Together with ctk3, required for ctk1/lsk1 CTD kinase activation (By similarity). Together with ctk1/lsk1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD.
Subcellular location: Cytoplasm. Nucleus. Note=Nuclear localization is dependent on ctk1/lsk1.
Interaction partners:
- CTD kinase subunit gamma
- CTD kinase subunit alpha
- Probable cyclin-dependent kinase 9
- Transcription elongation factor spt5
- Serine/threonine-protein kinase crk1
- Cyclin pch1
- Cyclin mcs2
- Transcription elongation factor spt4
- DNA-directed RNA polymerase II subunit rpb1
- Uncharacterized protein C13E7.08c
Sequence:
MAENENHVLSIRMSHPYYSEKEISRILSTRDPKENNLRMQAFAWISTLSKTLKFPVRTSGLAMLLYSRFQLFFPVNEIPLLECATACLVVASKIEDTAKKFRDILLAHYLQKHPGSEVDAHSQVCYKLIEENKKRILGLERMTLELICFDFRVRHPHNYMVKFAKSLKFSSSTASIAWNVCTDAYKTYTMLKYPAHIVAVASISIACKLQQLPQPIIPRSFFAPPALTEAVIADILDLYMHYQPHTCIGNMYTTEKLLGLCVDFQRAQKNSGRPQKPPQIDPHSSSLADEYRESNKRLQESKESCARFILDCDRKYFNTEFEKRMLEERRNKGTV
Protein: Platelet-derived growth factor subunit A (PDGF subunit A) (PDGF-1) (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) (P28576)
Organism: Rattus norvegicus (Rat)
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
Subcellular location: Secreted. Note=Released by platelets upon wounding. {ECO:0000250}.
Interaction partners:
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor beta
- Platelet-derived growth factor subunit B
- Platelet-derived growth factor C
- Platelet-derived growth factor D
- Insulin-like growth factor 1
- Pro-epidermal growth factor
- Protransforming growth factor alpha
- Receptor protein-tyrosine kinase
- Insulin-1
Sequence:
MRTWACLLLLGCGYLAHALAEEAEIPRELIERLARSQIHSIRDLQRLLEIDSVGAEDALETNLRAHGSHTVKHVPEKRPVPIRRKRSIEEAIPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATSNLNPDHREEETGRRRESGKKRK
Protein: FBD-associated F-box protein At5g38590 (Q9FFW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDKINGLPDDLLVKILSYVPTDIAVSTSILSKRWEFLWMWLPNLDYTSRWCRKPGDVGLRDFIHKNLPLHRAPVIESLRFHSNSPDIKPEDIRRWIEIAVSRHVHDLDIDHFSENENIFLSSFFACKSLVTLKLRSVTLRDIPSMVCLPSLKTLLLDNVSFVEGKSLQELLSICPVLEDLSVYCDDYENTKELTIVVPSLLSLSLYIPDEWLLDGYWIDTPSLEYLKLEDWNSCDHLSLIKNMPKLREAYVDAKCFLPKSVIESITSVKHLTICSKDGYGDGFVFNQLEHLTLCVCRGDSPSLLGQLLKDSPNLRILEISVMEDHVDDVGISLDGWNQPSSVPECLLSSLQIFKWPQYLGRPEDRDIAVYILKNARHLKKTTILADRCERFVTQRRMIKELLQALPARIC
Protein: Parapinopsin a (Parapinopsin-1) (A0A0N9NUD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
Sequence:
MHEEMESETSTAASGSIAEVMPRMGYTILAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFFGIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWGRFELEGVRTSCAPDWYSRDLANVSFIVCYFLLCFALPFSVIVYSYTRLLWTLRQVSRLQVCEGGSAARAEAQVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQFRDRALPFLLCGRNPWAAEAEEEEEETTVSSVSRSTSVSPA
Protein: Efflux pump vrtL (Viridicatumtoxin synthesis protein L) (D7PHY8)
Organism: Penicillium aethiopicum
Function: Efflux pump; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSKLSDNHSSASEGEKEAGDLESGPTAISSEPSFDDADRDPNLITWDGPKDPENPKNWPKGLRWKNTWTVSLFVFISPVSSSMIAPAMSDLAKSLGMHAEIEIYLSLSIFILAYSIGPIFFGPASELYGRVRLLQISNVWYLAWNLGCGFATTKGQLFAFRFLAGIGGSAPLAIGGGAISDMWTAEERGKAMGVYTLGPLLGPVVGPIAGGFIAEYSTWRWVFWSTSAAALAVQVVGFFWLQECHPGTLLRKRRDRLAKETGNENLHTAEKVETLGYKLLHAFERPVKMFTTQPIVFCMAIYMAYLFGISYLMFATFPEIWTVVYHESPGIGGLNYLSIAIGSFIGLFFNLKLVDRIYRSLKARNNGVGKPEYRMPSLAVGSVISTIGLFWYGWSIGNTHWIMPNIGALIFAMGTISCLQGMQTYIVDSYQTYAASAMAACAVLRSLCGFGFPLFAPYMYNSLGYGWGTSLLAFITMVVGWGAPFAFWHFGPRLRAMSKYASG
Protein: Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase-interacting protein A) (IPIP27A) (PH domain-containing endocytic trafficking adaptor 1) (Q8N4B1)
Organism: Homo sapiens (Human)
Function: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular location: Early endosome {ECO:0000269|PubMed:21233288}. Recycling endosome {ECO:0000269|PubMed:21233288}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21233288}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21233288}. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. {ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288}.
Interaction partners:
- Inositol polyphosphate 5-phosphatase OCRL
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Pleckstrin homology domain-containing family J member 1
- Homeobox protein cut-like 2
- Sesquipedalian-2
Sequence:
MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVVRELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSALPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRGQWLSSRVQP
Protein: Peroxisomal membrane protein PEX17 (Peroxin-17) (P40155)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the peroxisomal translocation machinery with PEX13 and PEX14. Interacts indirectly with the PTS1 receptor (PAS10/PEX5) and directly binds to PEX14. Required for import of both PTS1 and PTS2 proteins.
Subcellular location: Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Peroxisomal biogenesis factor 8
- Peroxisomal biogenesis factor 2
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein PEX14
- Peroxisomal targeting signal receptor
- Peroxisomal targeting signal 2 receptor
- Peroxisomal membrane protein import receptor PEX19
- Peroxisomal membrane protein PMP27
Sequence:
MTSINSFPRNIDWPSNIGIKKIEGTNPTVNAIKGLLYNGGSIYAFLYFVIAMFVEPTLQKQYQQRNDFSLFVLLRLRRIIAQLQKRLVMTPVSSLGFNEQNNFVERSTQTSDDNIIREDNSHWAEMIYQLQNMKQELQYFNRSSGQPSESIDDFVFQIKMVTDQVELTDRSRAFSNKSRNIIQGIREIKGWFVNGQVPR
Protein: Thyroid hormone receptor beta-A (TRbetaA) (xTR) (Nuclear receptor subfamily 1 group A member 2-A) (P18117)
Organism: Xenopus laevis (African clawed frog)
Function: High affinity receptor for triiodothyronine (T3).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MPSSMSGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIAVGMATDLVLDDNKRLAKRKLIEENREKRRKDEIQKSLVQKPEPTQEEWELIQVVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGVSLSSFSLDDTEVALLQAVLLMSSDRPGLASVERIEKCQEGFLLAFEHYINYRKHNIAHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Protein: Nucleic acid binding protein 2 (C9JMP5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYSTQQAPNKAVQNDSNPSASQPTTGPSAASPASENQN
Protein: Uncharacterized protein (Q9NEK7)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Insulin-like receptor
- Insulin-like peptide INSL5
- Dauer larva development regulatory growth factor daf-7
- Ceinsulin-1
- Forkhead box protein O
- INSulin related
- INSulin related
- Receptor-type guanylate cyclase daf-11
- Probable insulin-like peptide beta-type 3
- INSulin related
Sequence:
MNCKLIAIFAVLVLSVSAHLGAQAAAANFKAEGPLSRAVRVPGVAVRACGRRLVPYVWSVCGDACEPQEGIDIATQCCTYQCTAEYIQTACCPRLLL
Protein: L-ascorbate oxidase (EC 1.10.3.3) (F4K6Z5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- L-galactono-1,4-lactone dehydrogenase, mitochondrial
- Monodehydroascorbate reductase 3
- L-ascorbate peroxidase 3
- L-ascorbate peroxidase 1, cytosolic
- L-ascorbate peroxidase T, chloroplastic
- Monodehydroascorbate reductase 1, peroxisomal
- L-ascorbate peroxidase S, chloroplastic/mitochondrial
- L-gulonolactone oxidase 3
- Monodehydroascorbate reductase 2
- L-ascorbate peroxidase 2, cytosolic
Sequence:
MSYDEHTSSSFTYISQMGVWWIVLVVAVLTHTASAAVREYHWEVEYKYWSPDCKEGAVMTVNGEFPGPTIKAFAGDTIVVNLTNKLTTEGLVIHWHGIRQFGSPWADGAAGVTQCAINPGETFTYNFTVEKPGTHFYHGHYGMQRSAGLYGSLIVDVAKGKSERLRYDGEFNLLLSDWWHEAIPSQELGLSSKPMRWIGEAQSILINGRGQFNCSLAAQFSNNTSLPMCTFKEGDQCAPQILHVEPNKTYRIRLSSTTALASLNLAVQGHKLVVVEADGNYITPFTTDDIDIYSGESYSVLLTTDQDPSQNYYISVGVRGRKPNTTQALTILNYVTAPASKLPSSPPPVTPRWDDFERSKNFSKKIFSAMGSPSPPKKYRKRLILLNTQNLIDGYTKWAINNVSLVTPATPYLGSVKYNLKLGFNRKSPPRSYRMDYDIMNPPPFPNTTTGNGIYVFPFNVTVDVIIQNANVLKGIVSEIHPWHLHGHDFWVLGYGDGKFKPGIDEKTYNLKNPPLRNTAILYPYGWTAIRFVTDNPGVWFFHCHIEPHLHMGMGVVFAEGLNRIGKVPDEALGCGLTKQFLMNRNRN
Protein: PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) (O43189)
Organism: Homo sapiens (Human)
Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co-localizes with NEK6 in the centrosome.
Interaction partners:
- Histone-lysine N-methyltransferase EZH2
- Elongin BC and Polycomb repressive complex 2-associated protein
- Polycomb protein SUZ12
- Histone H3.1
- Histone H3.2
- Histone H3.1t
- Protein Jumonji
- Zinc finger protein AEBP2
- Histone-binding protein RBBP7
- Polycomb protein EED
Sequence:
MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
Protein: Secretoglobin, family 1B, member 27 (G3UXN8)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLTGALLLLGAALLLISEGDCGLCPALQRKVDLFLNGTTEEYVEYLKQFNENTKVLENAANIKKCSDRTLTEEDKAQATSLIVSLYVSC
Protein: Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] (P30416)
Organism: Mus musculus (Mouse)
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11751894}. Mitochondrion {ECO:0000250|UniProtKB:Q02790}. Nucleus {ECO:0000269|PubMed:11751894, ECO:0000269|PubMed:8341706}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. Colocalized with MAPT/TAU in the distal part of the primary cortical neurons. {ECO:0000250|UniProtKB:Q02790, ECO:0000250|UniProtKB:Q9QVC8}.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Prostaglandin E synthase 3
- Glucocorticoid receptor
- Progesterone receptor
- Heat shock 70 kDa protein 1B
- Stress-induced-phosphoprotein 1
- Peptidyl-prolyl cis-trans isomerase FKBP5
- Mineralocorticoid receptor
- Androgen receptor
Sequence:
MTAEEMKAAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYHKDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSRVETEA
Protein: Clathrin light chain 2 (O04209)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular location: Cell membrane. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, phragmoplast. Note=Cytoplasmic face of coated pits and vesicles (By similarity). Localized in the forming cell plate and the cortical division zone (CDZ) during cytokinesis. {ECO:0000250}.
Interaction partners:
- Clathrin heavy chain 2
- Clathrin heavy chain 1
- AP-2 complex subunit alpha-1
- Protein TPLATE
- AP-1 complex subunit gamma-1
- AP-1 complex subunit mu-2
- AP-2 complex subunit mu
- AP-1 complex subunit sigma-2
- Phragmoplastin DRP1C
- SWI/SNF complex component SNF12 homolog
Sequence:
MSAFEDDSFVILNDDASESVPVSGSFDATDSFSAFDGSLQVEDSVDDVFAAPSSDYGAYSNGDGIFGSNGDHDGPILPPPSEMESDEGFALREWRRQNAIQLEEKEKREKELLKQIIEEADQYKEEFHKKIEVTCENNKAANREKEKLYLENQEKFYAESSKNYWKAIAELVPKEVPTIEKRRGKKEQQDPKKPTVSVIQGPKPGKPTDLTRMRQILVKLKHNPPSHLKLTSQPPSEEAAAPPKNVPETKPTEAVTAA
Protein: Geranylgeranyl transferase type-2 subunit alpha 1 (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha 1) (Rab geranylgeranyl transferase alpha subunit 1) (AtRGTA1) (Rab-GGT alpha 1) (Q8VYB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -CCXX, CXXX, -XCCX and -XCXC, such as RABA1A, RABA2A, RABF2A and RABG2. In vitro, can prenylate PGGTI targets with the C-terminal Cys-aliphatic-aliphatic-X (CaaX) with leucine in the terminal position. Substrates with the C-terminal sequence -CSIL such as ARAC11/ROP1 or GG2/AGG2 are prenylated independently of REP and when the alpha subunit is associated with a beta subunit (RGTB1 or RGTB2).
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta 1
- Rab escort protein 1
- Geranylgeranyl transferase type-2 subunit beta 2
- AP-5 complex subunit beta-like protein
- Protein prenylyltransferase superfamily protein
- Tubby-like F-box protein 1
- Tetraspanin-13
- Peroxidase 6
- GDSL esterase/lipase At2g19050
- Ras-related protein RABG2
Sequence:
MHGRPRNASKPEEEAASAAKAVQLRSLQSQFMTNHHDKIYTNEAIELSTKLLEINPEAYTAWNYRKLAVEDRLARIEPDPNLVSAILDEELRVVESALRQNFKSYGAWHHRKWVLSKGHSSVGNELRLLEKFQKLDSRNFHAWNYRRFVVELTNRSEQDELQYTDDMINNNFSNYSAWHNRSVLLSSLLAQNADGFMPNIKIPEEYDFVHSAIFTEPDDQSGWFYHLWLLDQTLNVETPLLTSSWPSHGSSIILSGAGCLSGSSSMFTTFCSESGSFPLILYFDQAVGGVSSSTVTIDSELKGNEGLVWEPIPNKNSQVSCVWVARLKYVSSDPCEYKVKIRVGNSPGIVSSRGYNFNAPYEFVFTAHVHDTVEDSQEGIVSWTDGFDIWDAKSKDLNSLVTLDRLNAEMDFKWRQEAIDSEVECFGILPDSKIGKLTLARLLMAREAMVSDDAVKGVHYEEILQLYNDLMALDSSHYQYYKDEHSKAFLHKVTSSSESLSRHLLRYRDMNNLVCLRLNNLSLSRIASVEKLLFVQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSALDSLRHVKQLKVLDVSHNHIGKHSVDTTRYLCSSPLSNSELGQDDVGKQNPGLVTKYWDAYCVLTDLNLKQLDIAGNEIAGEEFSSFVLQVVPKLVWLDGQKKLGN
Protein: Mitochondrial import inner membrane translocase subunit TIM44 (Q9VDZ8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|PIRNR:PIRNR037871}.
Interaction partners:
Sequence:
MYRIAALVRDRACLFTCQQASQNLQQQQPRFYSAPGRRAGFFSQFFDNMKAEMDKNKEIKDNIRKFREEAQKLEESDALKSARQKFNIVESEAQKSSSMLKEQLGAIKERVGDVLEDASKSHLAKKVTEELSKKARGVSDTISDTSGKLGQTSAFQAISNTTTTIKKEMDSASIENRVYRAPAKLRKRVQLVMSDSDRVVEPNTEATGMELHKDSKFYESWENFKNNNTYVNKVLDWKVKYDESENPVIRASRLLTDKVSDVMGGLFSKTELSETMTELVKIDPSFDQKDFLRDCETDIIPNILESIVRGDLEILKDWCFESTFNIIANPIKEAKKAGVYLDSKILDIENIELAMGKVMEQGPVLIITFQAQQIMCVRDQKSQVVEGDPEKVMRVHYVWVLCRDRNELNPKAAWRLMELSANSSEQFV
Protein: Putative arsenical pump-driving ATPase (EC 7.3.2.7) (Arsenical resistance ATPase) (Arsenite-translocating ATPase) (Arsenite-transporting ATPase) (Q58542)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
Interaction partners:
- Uncharacterized protein MJ1141
- Cell division cycle protein 48 homolog MJ1156
- Orotidine 5'-phosphate decarboxylase
- Isoleucine--tRNA ligase
- Uncharacterized membrane protein MJ0091
- Uncharacterized membrane protein MJ0933
Sequence:
MLSKIKDSINSLRGITEKKLEKKDGTKYIMFGGKGGVGKTTMSAATGVYLAEKGLKVVIVSTDPAHSLRDIFEQEFGHEPTKVKGYDNLYVVEIDPQKAMEEYKEKLKAQIEENPFLGEMLEDQLEMAALSPGTDESAAFDVFLKYMDSNEFDVVIFDTAPTGHTLRFLGMPEVMDKYMTKLIKLRKQMSGFMKMMKKLLPFGGKDEDIDYDKMLEELEKMKERIVRARNILSDPERTAFRLVVIPEEMSILESERAMKALQKYGIPIDAVIVNQLIPEDVQCDFCRARRELQLKRLEMIKEKFGDKVIAYVPLLRTEAKGIETLKQIAKILYGEEEKEEQKIEQKVGQ
Protein: At5g38020 (S-adenosyl-L-methionine-dependent methyltransferases superfamily protein) (SAMT-like protein) (Q84MB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Oleosin family protein
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Methylsterol monooxygenase 1-3
- Glycine-rich protein / oleosin
- 3-ketoacyl-CoA synthase 16
- Regulator of chromosome condensation
- Probable glycerol-3-phosphate acyltransferase 3
Sequence:
MGVLSMKGGDGEHSYANNSEGQKRLASDAKPVVVETVKEMIVKTDFPGCIKVADLGCSSGENTLLVMSEIVNTIITSYQQKGKNLPEINCCLNDLPDNDFNTTFKLVPAFHKLLKMDVKGKCFISGVPGSFYSRLFPSKSLHFVHSSLCLHWLSKVPDGLEDNKKNVYLRSPCPPNVYKSYLTQFKNDFSLFLRLRADETVPNGRMALTFVGRKSLDPLSKDCFQNWSSISDSLLDLVSEGIVKESDVDSFNLPFYNPDESEVREVIESEGSFKISNFETIFGLLFSYKTGRTEVKDDDDNLDQSCRFEVIRKRASIIRSITEPMLGAHFGDAIMDRLFERYTYHLAERYDTLRNKPTVQFFVSLTRK
Protein: Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3) (O15484)
Organism: Homo sapiens (Human)
Function: Calcium-regulated non-lysosomal thiol-protease.
Interaction partners:
- Calpain small subunit 1
- Calpain small subunit 2
- Calpastatin
Sequence:
MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
Protein: BTB/POZ domain-containing protein At4g08455 (Q6DBN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
- Cytochrome P450, family 705, subfamily A, polypeptide 32
- Acetyltransferase At1g77540
- Berberine bridge enzyme-like 27
- At1g12570
- Monothiol glutaredoxin-S12, chloroplastic
- RNA ligase/cyclic nucleotide phosphodiesterase family protein
- Subtilisin-like protease
- Eukaryotic translation initiation factor 3 subunit K
- ABC transporter C family member 11
- ABC transporter C family member 13
Sequence:
MRCISCREEYLPRNAGTCKECYVEAGETEEELKREIDDLKAKVAFLRLSSSLDHGTSSTSRSFTDVVLIASEDNAGSPPIPAHKSVLVSRSPVFKAMLENEMEESLSGTIKISDVSYDALRTFVYYLYTAEACLDEQMACDLLVMSEKYQVKHLKSYCERFLVTKLSPDNSLMTYAFAHQHNAKHVLDAALSQIVENMDKLTKREEYMELVEKDPRLIVEIYEAYLSKQVNTAAGGTSTSKTS
Protein: Protein E6 (P50804)
Organism: Human papillomavirus type 70
Function: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
Interaction partners:
Sequence:
MARFPNPAERPYKLPDLCTALDTTLHDITIDCVYCKTQLQQTEVYEFAFSDLFIVYRNGEPYAACQKCIKFHAKVRELRHYSNSVYATTLESITNTKLYNLSIRCMSCLKPLCPAEKLRHVNTKRRFHQIAGSYTGQCRHCWTSNREDRRRIRRETQV