wanglab/gogpt-training-data huggingface dataset:
Protein: Four and a half LIM domains 1 (Q5JXH8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVE
Protein: Sequence-specific DNA binding transcription factor (A0A1I9LTW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F18C1.6 protein
- Homeodomain-like superfamily protein
- AT3g52230/F4F15_340
- Zinc knuckle
- Alpha/beta-Hydrolases superfamily protein
- YlmG homolog protein 1-2, chloroplastic
- Protein KINASE OF THE OUTER CHLOROPLAST MEMBRANE 1
- Tetratricopeptide repeat
- Fatty-acid-binding protein 1
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Sequence:
MFNSIHSLKSHLKKKYMENGESNQENLKSLNHDESLKKPSASSVVVDRLKRDEWSEGAVSTLLEAYESKWVLRNRAKLKGQDWEDVAKHVSSRATHTKSPKTQTQCKNKIESMKKRYRSESATADGSSWPLYPRLDHLLRGTQPQPQPQAVLPLNCSVPLLLLEPPLPAVAHPPQISYGSNGVGKIPKEDGFKPENKPEKDAEMDTDSSTPVVKTKVRGKKVKRRYKEEKEEIAGSIRWLAEVVMRSERARMETMKEIERMRAEAEAKRGELDLKRTEIMANTQLEIARIFAAAASSGQNKGVDSSLRIGRN
Protein: REF/SRPP-like protein At1g67360 (Q9FYF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Voltage-dependent L-type calcium channel subunit
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH8
- Transmembrane 9 superfamily member 8
- Seipin-1
- Alpha/beta-Hydrolases superfamily protein
- Seipin-2
- DNA N
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH6
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1
- ATP synthase protein MI25
Sequence:
METEKKNSKEVALKHLAFVRIATIHILASVSNLYEYAKQNSGPLKSAVEKVEGAVTTVVTPVYQKFKDVPDSLLVFLDHKVGEVSYKFDEHAPPMAKKVVNQAHVLIYKATEKAQSFVKEARTGGPKAAFNYAATEYKFFVVTNSVKVWAKLNQYKPIHAMGDKALPVAAHFSSRYNDLVTDMTNMGYSLVGYLPLVPVDDIVKAYEKEDARRKKGGDTAGKKGETTDAADGDKSSSDSE
Protein: Inactive tyrosine-protein kinase PRAG1 (Notch activation complex kinase) (PEAK1-related kinase-activating pseudokinase 1) (Sugen kinase 223) (Tyrosine-protein kinase SgK223) (Q571I4)
Organism: Mus musculus (Mouse)
Function: Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:D3ZMK9}. Nucleus {ECO:0000269|PubMed:25038227}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q86YV5}. Note=Colocalized with NOTCH1 in the nucleus (PubMed:25038227).
Interaction partners:
Sequence:
MSACSDFVEHIWKPGSCKNCFCLRSDHQPTAGHPKARANSLPAGTRLPARPENCRLDDEGVNGLAYSKPTIAVKPTMMTSETSDLWTEASLSAEVPKVNWRRTPGKLLLPKQEDEPIVYLGSFRGLQKPASPLACTDGNSRCPPAYTMVGLHNLEARVDRNTAFQPVSFQEEKAGREELPSAHESFRQKLAAFAGMTSSCPKGPRPCTSPQPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCCPESKDAVHSTEGSGRRGGDCSPTCREQGPRTRPTEEEKQGLSFPRECCGQGSTANPPRLGPKKPSLNSEAASSSDGLSCGSSRSGASSPFAPHLENDYCSLVKEPASGKQQDLSGHFLTSGKCVGQAAELQPASLLRDPVQPEPIYAESAKRKKAAPGPPRPEPKKEQVPAGHSQGQVWTGDTWIQKTPPSWSQDREGANPAPQVATTITVIAAHPEEDHRTIYLSSPDSAVGVQWPRGPSNQDLQAGEEEPLVAQGLTSRESHPHNVTENTAKEKPAIPPKLSKSSPGGSPVSPAPPLTDHSDGNTGGSSVGPQLLSRVPANLTSSCHTNGVATAGDSAKCPPPATSSSVLDQRRPRYQTGAWSRQCRIEEEEEVGQELSQSWGRELENGTADHSNSSTWHRLHPIDGTSGQNSKTNSGMSKSASFAFEFPKDRGRLEAFSPPPPPPKSRHLLKMNKSSSDLEKVSQSSAESLSPSFRGAHVSFTTGSTDSLASDSRPCSDGGPSYEPTHSPTISGKKLFAPVPFPSGSTEDVSPGGGPAQPPPLPQKKIVSRAASSPDGFFWTQGSPKPRTASPKLNLSHSETNVCAHDEPPFNCSLNSGNRSHHVFSSSEPLGKAFKGNAPWAPALGLANSKGGCGSPSLQCRAATSTSSSQLSVSSQASSSSTQLQLHSLLSSISSKEGTYAKLGGLYTQSLARLVTKCEDLFMGGQKKELRFNENYWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSIYAVKICKTPEPKSASYCSPSVPVHFNIQQDCGHFVASVPSSMLASPDTSSKDTAPAVSPQPPAQEQDCVVVITREVPHQTASDFVRDSMASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHCNPQSSPGPSATPTVPTTTSRCPSAAPAATTACQGGPGEKQLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVEQPCTSEEVLCNTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLCCQYLASAEPGALLQSLKLLQLL
Protein: Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) (P41593)
Organism: Mus musculus (Mouse)
Function: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8197183}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Parathyroid hormone-related protein
- Parathyroid hormone
- Guanine nucleotide-binding protein G
- Tuberoinfundibular peptide of 39 residues
- Beta-arrestin-2
- Low-density lipoprotein receptor-related protein 6
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-12
Sequence:
MGTARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKAPGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLLPATTNGHSQLPGHAKPGAPAIENETIPVTMTVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
Protein: Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Q9UQE7)
Organism: Homo sapiens (Human)
Function: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CW03}. Chromosome {ECO:0000250|UniProtKB:Q9CW03}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9CW03}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9CW03}.
Interaction partners:
- Cohesin subunit SA-2
- Nipped-B-like protein
- Double-strand-break repair protein rad21 homolog
- Sister chromatid cohesion protein PDS5 homolog A
- Meiotic recombination protein REC8 homolog
- Wings apart-like protein homolog
- Structural maintenance of chromosomes protein 1B
- Cohesin subunit SA-1
- Cohesin subunit SA-3
- Structural maintenance of chromosomes protein 1A
Sequence:
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTHG
Protein: Tachykinin-related peptide 1 (TKRP-1) (P86587)
Organism: Pentatoma rufipes (Forest bug) (Cimex rufipes)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
GPSGFLGMR
Protein: Probable zinc transporter protein DDB_G0282067 (Q54T06)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MYNKNNNNNNIIDDNDYDDDDDDYNYYNNNNYDYNENLISKDTKKQKDLEKEPLSKSIAFISIGTLTLLYVIVELGAALYVGSLTLLSDGFHNLSDVVSLVIAWWAQKAAKRDSDNFMSYGWARAEILGGLTNGCFLLSMSLYVALEAIPRFIRPEPMESGLIFMIVAGSGLAINILGTIVFACTGMSHAHSHGGGGHSHGGGGGHSHGAEKEKKKEKHGHSHDGADKEKKKEKHGHGHSHSTATTAVGINSEEHNHDDHDHHDHSEESHGHSHGGEKKKEKKHGHSHSHGGGAAEGININDEHDHDHEGHHDHSEENHGHSHGGSEKKKEKHGHGHSHDGGVEKKKEKHGHSHDGVEKKKKKKKSSGTCLGMDLNMFGVFLHFLGDAISSLFVLITGAVIHFTHGKWTEYIDPAVSLIIVIMIAATSAPLVKRCSMILLQKVPDDIDLDSIRYKIAKVEGVVSQHDLHVWQLVDGMTIASVHVGIEQGREFQSIASKLRKIFHKEGIHSTSIQPEFLPINSFTGGATSDPNFCIQNCVDDCEEEWCCKKSADRIRMRNFNSKNSNIVDINDI
Protein: Synaptopodin 2-like protein (Q9H987)
Organism: Homo sapiens (Human)
Function: Actin-associated protein that may play a role in modulating actin-based shape.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Myozenin-1
Sequence:
MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRPGAGHQ
Protein: Unconventional myosin-If (P70248)
Organism: Mus musculus (Mouse)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
Interaction partners:
- F-actin-uncapping protein LRRC16A
- Actin, cytoplasmic 2
- Myosin XVIIIb
- Mitogen-activated protein kinase kinase kinase 1
- Thymosin beta 15b like
- Cytospin-A
- Actin nucleation-promoting factor WAS
- Actin-related protein 2/3 complex subunit 3
- Myosin-IIIa
- Actin-related protein 2/3 complex subunit 2
Sequence:
MGSKERFHWQSHNVKQSGVDDMVLLSQITEDAIVRNLHKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAVQYEEPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQQQNLGIMSQDYYYYLNQSDTYKVEGTDDRSDFSETLSAMQVMGFRQACQQLVLQLVAGILHLGNISFCEEGNYARVESVDSLAFPAYLLGIDSGRLQEKLTSRKMDSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQSSDQDFLRMLFPEKLNIDKKGRPSTAGSKIKKQANDLVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRENIRVRRAGFAYRRQFSKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEMRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGNYLGLEERPELRQFLAKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGTEKVKRGPEKGLVREVLKKKLDIQALRGVSLSTRQDDFFILQEEAADTFLESIFKTEFVSLLCKRFEEAARRPLPLTFQDILQFRVKKKGWGGGGTRNVTFSAGQVNLAVLKAGGKTLTISLGDGLPKNSKPTRKGLAQGKPRRSAQAPTRAVPWASQGLNRNGATLFPRGEGPYTLEIYIWPQEFPEASTAIHLQPQDASRRPRARPPSEHSTEFLNVPDQGVAGMQRKRSIGQRPVPASRPKPQPRTHGPRCRALYQYIGQDVDELSFNVNEVIEILIEDSSGWWKGRLHGQEGLFPGNYVEKI
Protein: Copper transporter MctB (Mycobacterial copper transport protein B) (P9WJ83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:18434314, ECO:0000269|PubMed:18439872}.
Interaction partners:
- SteA-like C-terminal domain-containing protein
- Outer membrane protein Rv1973
- Tyrosine recombinase XerD
- DNA repair protein RecN
- CTP synthase
- ADP-ribose pyrophosphatase
- Uncharacterized protein Rv1351
- Peptidoglycan-binding protein ArfA
- NAD kinase
- 16S/23S rRNA
Sequence:
MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ
Protein: Origin recognition complex subunit 5 (O43913)
Organism: Homo sapiens (Human)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}.
Interaction partners:
- DNA replication licensing factor MCM5
- Origin recognition complex subunit 1
- Origin recognition complex subunit 3
- Origin recognition complex subunit 4
- Origin recognition complex subunit 6
- Cell division control protein 6 homolog
- Origin recognition complex subunit 2
- DNA replication licensing factor MCM2
- DNA replication factor Cdt1
- DNA replication licensing factor MCM3
Sequence:
MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYDFL
Protein: Protein URE2 (Q96WL3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Interaction partners:
- Gst1p
- Gst3p
- Thioredoxin peroxidase
- Gst2p
- Glutathione reductase
- Glutathione synthetase
- Ecm38p
- Glutathione hydrolase
- glutathione transferase
- glutathione transferase
Sequence:
MMSTDQHIQQNMNDNSNNSNNSNNNNTNNNNNNQSVNVNVNNTNNNTQTISNLSAGLKSVSLTDQQQNEVNLNLLQQQLHQEASTQQQQSRITQFFQNQPTEGFTLFSHRSAPNGFKVAIILSELNLPFNTFFLDFNNGEQRTPEFVTINPNARVPALIDHYNDNTSIWESGAITLYLVSKYLKENGECSLWSNNLIEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRFFDHPVWLVGDRTTVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKHMMQRPAVKRALRGD
Protein: Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen) (O35167)
Organism: Rattus norvegicus (Rat)
Function: Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
Subcellular location: Synapse {ECO:0000250}.
Interaction partners:
- Muscle, skeletal receptor tyrosine protein kinase
- Acetylcholinesterase
- Docking protein 7
Sequence:
MAVLNPMTLGIYLQLFFCSIVSQPTFINSVLPISAALPGLDQKKRGNHKACCLLMPPPPPLFPPPFFRGSRSPLLSPDMKNLLELEASPSPCMQGSLGSPGPPGPQGPPGLPGKAGPKGEKGDLGRPGRKGRPGPPGVPGEPGPVGWPGPEGPRGEKGDVGMMGLPGSRGPMGSKGFPGSRGEKGSRGERGDLGPKGEKGFPGFPGMLGQKGEMGPKGESGIAGHRGPTGRPGKRGKQGQKGDSGIMGPPGKPGPSGQPGRQGPPGPPGPPSAGQLVMGLKGERGFPGPPGRCLCGPPANVNNPSYGDPMYGRGSPRVPAIFVVNNQEELEKLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVGLHHKAAWHLCGDGVLQPGEECDDGNPDVSDGCIDCHRAYCGDGYRHRGVEDCDGSDFGYLKCETYLPGSYGELRCTQYCSIDSTPCRYFT
Protein: ER membrane protein complex subunit 3 (Transmembrane protein 111) (Q9P0I2)
Organism: Homo sapiens (Human)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656}.
Interaction partners:
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 9
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 5
- Endoplasmic reticulum membrane protein complex subunit 7
- Derlin-2
Sequence:
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF
Protein: Probable multidrug ABC transporter permease YbhR (P0AFP9)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable multidrug ABC transporter ATP-binding protein YbhF
- UPF0194 membrane protein YbhG
- Probable multidrug ABC transporter permease YbhS
- HTH-type transcriptional dual regulator CecR
- Lipopolysaccharide export system ATP-binding protein LptB
- Uncharacterized protein YhiI
Sequence:
MFHRLWTLIRKELQSLLREPQTRAILILPVLIQVILFPFAATLEVTNATIAIYDEDNGEHSVELTQRFARASAFTHVLLLKSPQEIRPTIDTQKALLLVRFPADFSRKLDTFQTAPLQLILDGRNSNSAQIAANYLQQIVKNYQQELLEGKPKPNNSELVVRNWYNPNLDYKWFVVPSLIAMITTIGVMIVTSLSVAREREQGTLDQLLVSPLTTWQIFIGKAVPALIVATFQATIVLAIGIWAYQIPFAGSLALFYFTMVIYGLSLVGFGLLISSLCSTQQQAFIGVFVFMMPAILLSGYVSPVENMPVWLQNLTWINPIRHFTDITKQIYLKDASLDIVWNSLWPLLVITATTGSAAYAMFRRKVM
Protein: Peroxisomal biogenesis factor 5 (F5GYB4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLA
Protein: Uncharacterized protein (Q387G1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKKLRSFLPWVCGVSCGAAVPCHSSRCTSTLASTSWHGRDSNAPSHRQQACLSSTEKRLRRSGEKLARRSTSAVLIKIADLSSTLPPQGIRCCEDLEGAPLNTDDRLQVLLNTCISTPSAELYEELIRSSAALYRSSAAQHWGFYARVLANYGVQCLVDQNTGKAVEVLRKAIEIISFFEADTAVLHLRVLLANAAACEGQYFAALCEYESCLAVMRDFPVESSLRQLVSGSEMYMPLSRSYINEDYDRFLEDEEVVLRALGQGQKQADACVDKAEKARVAMTMARLQRRRGEKDASLTLYTSALRMLLGAHNPDLEIQVLHDIGLLLCFEVLDVTQGLPYLQAAAEMACDRARVELNGPNSDQGESGPSHSSYPLVRTNMEKGLRARRAVLALVDTAVCYAENDEVGKSLGFFEEAKSLMTECGMQEHSAWICMKYADALSSASLLDAAIRIYLDAMDTIRLTEISGEKMQLACMGMGMYLTQSEVEGRLAHCFQTRVGDYRRACVHYCQSIRRCGVAVRCPFQVSQEGKTLAEEEIDPETLCWMLEKYADCCVRVGNVKIAKEVLEHRVRVEQGVGTPCAAALLHLAELHSNDNVPRAIELYTRILSLPQDAVEPDTLLQSAYNFIAVCYQSKDEDFEAGLSNVQCSQSSGQGDMVDENTPTSSELAPVDYENSIIATFKKSANVILASHTVNKTKLCTNRDDELKTLMALSRAGFFCQRRGYESGAEELYRLAVDYARLTDVKCKEYSRELAVMLANYATVVVHKDTELAKKLYEEAVATCPTDENVSNAAASFFVLTANYAEGRACIERLVAATTTNAVLQGLYGKLAWLGVVCWDELLHEERLLCLKHMLFALGTESDAVVAVTAKSQPNPFAGPLPEDFKQRLLRGVTISNDQETVSLACYIAQTKLFHEGRFINSCYKVALKRFPQGATILVNYAKFCGDYNAVVLARKYYAKAFALSHTDLRITECYAHYLAFLNGGERQRSEHRQVVCGESLVRFQVERSALVTCAIQHAQSLTLYGNYVATSMPSPSVPVVSFEEALRLNPADSRATSLYCSFLSNVYGSALDMKKNPEAKEQLARKVTDCYLSCLKLQPHSVAVLTGLGSIYIDLGGRFEDAVRVLERARQLSPNNPTVHRLLCTAFHEEWVREQQSETTLTNKRLQWLLTTTHKLYEATIALEPTNSVVLARYCQFAHHGLQDNALATQLMQRLRELSRE
Protein: LPS-assembly protein LptD (Q8ZRW0)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Subcellular location: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01411}.
Interaction partners:
- LPS-assembly lipoprotein LptE
- Lipopolysaccharide export system protein LptA
- Lipopolysaccharide export system protein LptC
- Outer membrane protein assembly factor BamA
- Chaperone SurA
- Outer membrane protein assembly factor BamD
- Outer-membrane lipoprotein carrier protein
- Outer membrane protein A
- Outer membrane protein assembly factor BamB
- Outer-membrane lipoprotein LolB
Sequence:
MKKRIPTLLATMIASALYSHQGLAADLASQCMLGVPSYDRPLVKGDTNDLPVTINADNAKGNYPDDAVFTGNVDIMQGNSRLQADEVQLHQKQAEGQPEPVRTVDALGNVHYDDNQVILKGPKGWANLNTKDTNVWEGDYQMVGRQGRGKADLMKQRGENRYTILENGSFTSCLPGSDTWSVVGSEVIHDREEQVAEIWNARFKVGPVPIFYSPYLQLPVGDKRRSGFLIPNAKYTTKNYFEFYLPYYWNIAPNMDATITPHYMHRRGNIMWENEFRYLTQAGEGVMELDYLPSDKVYEDDHPKEGDKHRWLFYWQHSGVMDQVWRFNVDYTKVSDSSYFNDFDSKYGSSTDGYATQKFSVGYAVQNFDATVSTKQFQVFNDQNTSSYSAEPQLDVNYYHNDLGPFDTRIYGQAVHFVNTKDNMPEATRVHLEPTINLPLSNRWGSLNTEAKLMATHYQQTNLDSYNSDPNNKNKLEDSVNRVMPQFKVDGKLIFERDMAMLAPGYTQTLEPRVQYLYVPYRDQSGIYNYDSSLLQSDYNGLFRDRTYGGLDRIASANQVTTGVTTRIYDDAAVERFNVSVGQIYYFTESRTGDDNIKWENDDKTGSLVWAGDTYWRISERWGLRSGVQYDTRLDSVATSSSSLEYRRDQDRLVQLNYRYASPEYIQATLPSYYSTAEQYKNGINQVGAVASWPIADRWSIVGAYYFDTNSSKPADQMLGLQYNSCCYAIRVGYERKLNGWDNDKQHAIYDNAIGFNIELRGLSSNYGLGTQEMLRSNILPYQSSM