wanglab/gogpt-training-data huggingface dataset:
Protein: MyoD family inhibitor (Myogenic repressor I-mf) (P70331)
Organism: Mus musculus (Mouse)
Function: Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
Subcellular location: Nucleus. Cytoplasm.
Interaction partners:
- Myoblast determination protein 1
Sequence:
MSQVSGQCPSRCDAPHGVPSAALDPAQTMSLLPGLEVARSTHPVEASSEEGFPEEAAPSMPHDSGLRAQQALNSIDLDVPTEAVTCQPQGNPQGCTPLLPNGSSHDHLSEPGSAGHAGNGALGGSKAHRKLQTHPSLGSQAGRKSRGSARSASQVPLQAQEGKAPAVRIHRQTASPTCCLRNAQLSGTALRSLRLESQGHRELNNKTLSQSNNKKPGVAAHAAIIPALTRPKQNCHDPSLLPGTHGVGKEF
Protein: Transcription factor BHLH6 (Basic helix-loop-helix protein 6) (OsbHLH6) (osbHLH006) (bHLH transcription factor 6) (Q0JEB7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in phosphate starvation response. Acts as positive regulator of phosphate homeostasis and phosphate signaling by antagonizing SPX4. Transcription factor involved jasmonate signaling. Regulates shoot growth inhibition in response to jasmonate. May play a role as transcriptional activator in the regulation of jasmonate-mediated stress-inducible gene expression. Possesses transactivation activity in vivo.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:33128314}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22456953, ECO:0000269|PubMed:33128314}.
Interaction partners:
- Os04g0563801 protein
- Os03g0294600 protein
- Os12g0568800 protein
- Importin-beta1
- Aurora kinase
- Aurora kinase
- Membrane-associated zinc metalloprotease family protein, expressed
- Probable zinc metalloprotease EGY3, chloroplastic
- Os01g0654200 protein
- Os05g0388025 protein
Sequence:
MDAEMAMGESFAYYWETQRYLESEELDSMYLPTQDDSNYESSSPDGSHSSSAPAPAAVGGDAAAAVAGSGGGMTTMMMGGGGGGGDDAGGANKNILMERDRRRKLNEKLYALRSVVPNITKMDKASIIKDAIEYIQRLQAEEQQMLREVAALESAAAASAAPAAANPFAGLGADEEHEYGHHHPSSSSERTKKVKRALSVSSISDALLAAAAPAPPVEIQELRVSEVGDRVLVVSVTCSKRRDAMARVCRALEELRLRVITANITSVAGCLMHTLFVEVDHMDSVQMKQMVEAALSQLVATGSPLSSMSY
Protein: Bifunctional muramidase/DL-endopeptidase CwlT (EC 3.2.1.17) (EC 3.4.-.-) (Bifunctional cell wall hydrolase CwlT) (Cell wall lytic enzyme T) (P96645)
Organism: Bacillus subtilis (strain 168)
Function: Exhibits both muramidase and DL-endopeptidase activities. The N-terminal region acts as a N-acetylmuramidase, which cleaves the bond between N-acetylmuramic acid and N-acetyl-D-glucosamine (MurNAc-GlcNAc) in peptidoglycan. The C-terminal region acts as a DL-endopeptidase that cleaves the bond between D-gamma-glutamate and meso-diaminopimelic acid. Cannot degrade purified B.anthracis peptidoglycan, which differ from those of B.subtilis. CwlT is required for ICEBs1 conjugation: the muramidase activity is essential, whereas the peptidase activity is partially dispensable for transfer of ICEBs1.
Subcellular location: Secreted {ECO:0000305|PubMed:24532767}. Note=Accumulates in culture supernatant and some of it is found associated with the cell (PubMed:24532767). The putative signal sequence is required for CwlT to function in conjugation, but the putative lipid attachment site is not (PubMed:24532767). {ECO:0000269|PubMed:24532767}.
Interaction partners:
- Uncharacterized protein YddE
- Uncharacterized membrane protein YddG
- Ftsk domain-containing protein YdcQ
- Putative DNA relaxase NicK
- Uncharacterized protein YddF
- Putative uncharacterized protein YdcP
- Uncharacterized protein YddA
- Uncharacterized protein YdcT
- Uncharacterized protein YdcS
- Uncharacterized protein YddD
Sequence:
MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGGDGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESIGLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTKKLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALKYEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDLVFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK
Protein: Austinoid biosynthesis clusters protein H (Q5AR31)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Interaction partners:
- Cytochrome P450 monooxygenase ausG
Sequence:
MVMTNILCQILSDDLPELPPCREPSKGMIVGNLGMTSNTMTTEGPFAKLDVESVLSFMSPSCTLRSFPSSLGKPALQTKEESKADFQGLKDFFYNFQLRVKDGAEPVIDEPARKVVLHIEGKGDSLVGRFETEYVYILQINEEGTMVEDFFQFADSATRDAWGKKIEAHFSARN
Protein: Protein Shroom2 (Apical-like protein) (Protein APXL) (Q13796)
Organism: Homo sapiens (Human)
Function: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with cortical F-actin. {ECO:0000250}.
Interaction partners:
- Rho-associated protein kinase 1
- G-protein coupled receptor 143
- Tight junction protein 1
Sequence:
MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK
Protein: Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) (P25390)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
Interaction partners:
- Osmolarity two-component system protein SSK1
- MAP kinase kinase PBS2
- High osmolarity signaling protein SHO1
- MAP kinase kinase kinase SSK2
- Osmosensing histidine protein kinase SLN1
- Phosphorelay intermediate protein YPD1
- Protein STE50
- Signaling mucin HKR1
- Serine/threonine-protein kinase STE20
- Protein OPY2
Sequence:
MMMDILNTQQQKAAEGGRVLAPHTISSKLVKRLSSHSSHKLSRSDLKALGGSETISDGPSQLTFKDRYVFNESLYLKKLKKTALDDYYTRGIKLTNRYEEDDGDDEIIRLSNGDRIDEDLHSGVKFFSTTPYCRKMRSDSDELAWNEIATERFKWQSMLARVLKGDIVKGEKTRIANQVKKPGLNKELSDEIWLELKAWLNGRTMQEMEQSLTYLRDSSDSVFEEIMKFQIPQGKILSLDALEAILQDLMNRYHSVVSYWPNLKKMYKDKPITNTAEFTARIDVMNSWLNFKTNLTLRRQELDDWINRFSPISSSDNCQEDFDGVPQWNCKMKILAEQLMKEKNIESIFQKKIFYPLSPWMFKLKLHFIVYRETLTKMNIKYPYERLRSLLAFPVYLIKEVILTRLSYARKLKNPTMMMIDQMIDDFNAFIRLSVQLKYTLTKYCSNLPFDVDFDPTFENTVIEAIRYLFFLLNLKLIDSSKQNFKAPDLLLKYWDHLKNTGHYINGAETVIPNEFLKLTLRLVHKLQFYLLKQQNFPPTFANASEAEKWLSSIFENLGAMKRKLNRFSNILVKAFQNSAVYQINHNAQLVKKLKDAHYFLVYSGNTFESSGVYMFAAPELLGCDNDTILRILRNKSIGCDLVPKLDIGNNLNVYDITTKETDLNILVSKGEDSKGIPYYRVVANSSSDLDRHAHQSKKKNFSTDPFDQHLDEKNNEVFELEVALSSLGALVVLYPGEPVVWDGPVYKLPGNNLFASNEMDLGKIGNPNTLILLNQGSNYALTYQIDKFNQTVGDSVSFIEKRCSLNSIESSLQKINKAYYKLTYTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLGMNWLKFLVEECDPTDQRTFRWCVLAMDFAMQMTSGYNILALNVKQFQELKERVSVCMSLLISHFDVMGARATEAENGMQQARLNIDTEENIDEEATLEINSRLRLEAIKTLEKTMKRNPRQMGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIREIAFGNSEKDQVPILSS
Protein: Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) (Q9H9H4)
Organism: Homo sapiens (Human)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:15218037}; Peripheral membrane protein {ECO:0000269|PubMed:15218037}. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.
Interaction partners:
- Multivesicular body subunit 12A
- Vacuolar protein sorting-associated protein 28 homolog
- Tumor susceptibility gene 101 protein
- Multivesicular body subunit 12B
- Ubiquitin-associated protein 1
- Vacuolar protein-sorting-associated protein 25
- Charged multivesicular body protein 3
- Charged multivesicular body protein 1b
- Vacuolar protein sorting-associated protein 4A
- Charged multivesicular body protein 6
Sequence:
MAGAGSEARFAGLSLVQLNELLEDEGQLTEMVQKMEETQNVQLNKEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQEMVLKGQRLPQALAPLPPRLPELAPTAPLPYPAPEASGPPAVAPRRIPPPPPPVPAGRLATPFTAAMSSGQAVPYPGLQCPPLPPRVGLPTQQGFSSQFVSPYPPPLPQRPPPRLPPHQPGFILQ
Protein: GH27401p (Hermansky-Pudlak syndrome 1) (Q7K3N1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Hermansky-Pudlak syndrome 4, isoform A
- Uncharacterized protein, isoform A
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- BLOC-2 complex member HPS5 homolog
- Dysbindin protein homolog
- Rab32, isoform B
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 5
Sequence:
MNGLIVFNSANDVVYQKLNEPLAQKIRSVATTQGLLQSGGSLDSNILLQIFSPIVGSQRIMQCQFDNAYSSLQCEQGFNLVFGELLGFTFLKIGQIPVELLGRQMGVAITLTRYCYGANLFAAQAGAMQQELLTQCLDCYETLLWEEDQTYLLEAMPRLLINTELKRTVHLTLDATLEHLRQLGLPRAHALLLVSNKLVAANSTRQALPLAAADLLFLSLMSRALQAPKSPSQRAVAVFLQGVSYDVNSGCVPSIVHISRLHGNQVLLQVIEYAHMPLTSCIYDSFFVLQKIVAVQHQGDSDALKPAFENLESFIVQALTALKRYLKQRSETDDLENCTKKFAAKWENLRKMYTEYFKNFERELLVRIESNLPSFGEELKQIFTLACCDSSSVHELDQLSDTAANVEAKLLEFAEFLAVKATRNISIDAYLEDFPGLVHFMYVNRSRGQMLAPDLRPNQLVPKTKLWSMVEIARNYLKKGQTTVMWKDKAFHYSYFLWFEDMSGGVLSTVVDLQHHFLSTGAASGNGSKSPTEPGALTMDYYHDLAELCFPKLSPAKVRVYELYCIHLGLVTATCAVEHARRLVATISDVVGEEAF
Protein: Uncharacterized protein YDL144C (Q07589)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YFR018C
- Putative pyridoxal reductase
Sequence:
MSRILVIGAGGVGVITALSLWLKKESDVSLVVRSDYDRVLKHGYTIESCDYGRLEGWRPHHIYSSVEDAASAADNQGYNYIVVTTKNIIDGPVNSRVSNIIRPVLEKNKELHGPQLTTHILLVQNGIDIEKEIWAEFPREQYRYTVLSGIQLIGSTKIGSGHISQVGQDHLSCGAFDPQDAAAIQAANDFVRMYSNEGQNFVEFDPRVRYSRWKKLLYNAAINTSTALVGLDVPRCLEFGVNKKSTEIEVFHPAMREIIAIAASEGIIIEEEFITMFTEITRKKVFKPSMCVDCEKGQLMELEVILGNPIRIAKRNGVATPTLSILYNLLVLVQAKLKERKGLLKFDEKTATLVDE
Protein: Protein MSS2, mitochondrial (P40990)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required to stabilize mitochondrial cytochrome C oxidase subunit 2 (COX2) and to translocate the C-terminal domain of COX2 through the inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}.
Interaction partners:
- Cytochrome c oxidase assembly protein COX18, mitochondrial
- Pentamidine resistance factor
- Inner membrane mitoribosome receptor MBA1, mitochondrial
- Mitochondrial inner membrane protein OXA1
- mRNA-binding protein PUF3
Sequence:
MQRFVSKFVSTPPVPKKFQEIFPKKRTVNKILFQLDTRLTYHEMYPIFLQVSQNTNEENIPWRKKYPYIRSSDIMQMRNVLITLRTQNKFVHKDLLAMEDKLLNIAAELGNNDAISILSFNVIHEYKKENVKSSYEKDIETANEFIKKLYARNHHLTVKLIGDLFFENKTYDKAEKYYQEFLKLENSTKLAGEVHGKLGEIQIKQVNGFLKAEKSWLSCIELLEIERSSRWYFLLARLYMSSEPMKAKALLENCASIGFKECFKTLGFLELNYFNNYERAKEWFKTGMEIMDLECFFGFFDCCVKEENFKGARDCLESVKKLGNDKDKKTMINVFLESRKDSIKLLDKARL
Protein: R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Q9BXY4)
Organism: Homo sapiens (Human)
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q2TJ95}.
Interaction partners:
- Leucine-rich repeat-containing G-protein coupled receptor 4
- E3 ubiquitin-protein ligase ZNRF3
- Leucine-rich repeat-containing G-protein coupled receptor 5
- E3 ubiquitin-protein ligase RNF43
- Leucine-rich repeat-containing G-protein coupled receptor 6
- Syndecan-4
- Protein Wnt-3a
- Furin
- Catenin beta-1
- Frizzled-8
Sequence:
MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
Protein: Polyprenol reductase (Q386U2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MELIGCPAVAVLTCFYWVASHLVLLLRVALPRFSVIVRYGGRCVTSESICSGFASWIQSSRDYAKRTVGMWKSERLSRAVFHCTAILEGSILCRIRVSRKLSFCAFYVAGIVSIVLILILMDGGHCSPIVEGMTVYSDGLNHSAVAFLVSYAGRPLLAFLMHCTVRLLECLFLHRFRGGSDDCVTGFAAVAGCSFYVFASCSSGIILPCTERSPLVIGGQRVVNGMTEASPFFPTFALAVDALFVLHMVFQVTQVYHHWVLAELRRKPVGTSVLKGEHCSVGRCKTTPKGVSEEGRIGDGSAVLYHFPRIALFKYVQEPHYACEVAMYAVNAISICLIVYNRSLPSGGTGREIGDEFSVGSEVVPLLCATCLPPLGVLFFSLFNLAITAREHRRFWECVNARRGDGERELIPKWDLFYGVW
Protein: Glycine betaine transporter BetP (Glycine betaine permease) (P54582)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: Involved in response to osmotic stress. High-affinity glycine betaine-specific uptake system, which couples the uptake of glycine betaine to the symport of two Na(+) ions. Transport is driven both by the Na(+) gradient and by the electrical potential. In addition, functions both as an osmosensor and as an osmoregulator that transduces signal to the catalytic part of the carrier protein, which adapts its activity to the extent of osmotic stress.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:17390131, ECO:0000269|PubMed:19262666}; Multi-pass membrane protein {ECO:0000269|PubMed:19262666, ECO:0000269|PubMed:21364531, ECO:0000269|PubMed:22940865, ECO:0000269|PubMed:24141878, ECO:0000269|PubMed:25023443}.
Interaction partners:
- Ectoine/proline transporter ProP
- Large-conductance mechanosensitive channel
- Probable potassium transport system protein Kup
- DNA-binding response regulator MtrA
- Sensor histidine kinase MtrB
Sequence:
MTTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNWSVIVPALVIVLATVVWGIGFKDSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAASKFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTTEPLTFYRNGVPGHDEHNVGVAMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDILAIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGKGIQYLSNANMVLAALLAIFVFVVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAGEWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILGVLLVPAGVSTVWFSIFGGTAIVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMSQHGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFALVKDLSNDVIYLEYREQQRFNARLARERRVHNEHRKRELAAKRRRERKASGAGKRR
Protein: Sp4 transcription factor (A0A3B3IRW4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF
Protein: COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) (Kip1 C-terminus-interacting protein 2) (O35864)
Organism: Mus musculus (Mouse)
Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10721695}. Nucleus {ECO:0000269|PubMed:10721695}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q92905}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q92905}. Note=Nuclear localization is diminished in the presence of IFIT3. {ECO:0000250|UniProtKB:Q92905}.
Interaction partners:
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 7b
- Transcription factor Jun
- COP9 signalosome complex subunit 7a
- Ubiquitin-like protein NEDD8
Sequence:
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA
Protein: General transcription factor group E6 (F4J6V6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MADSVPGHVAGGGLQGFSVDAECIKQRVDEGFSLNNVVYRVLNLGIFVLHRYELLEHKLKEVEEFYSSIGVSNSGSIGKDTEKGRHVVGIRKIQQEAARREAVAAKRMQDLMRQFGTIFRQITQHKCAWPFMHPVNVEGLGLHDYFEVIDKPMDFSTIKNQMEAKDGTGYKHVMQIYADMRLVFENAMNYNEETSDVYSMAKKLLEKFEEKWAHFLPKVQEEEKIREEEEKQAAKEALLAKEASHIKTTRELGNEICHANDELEKLMRKVVERCRKITIEEKRNIGLALLKLSPDDLQKVLGIVAQANPSFQPRAEEVSIEMDILDEPTLWRLKFFVKDALDNAMKKKKEEETKTRELSGAQKKEVSKKRNATTKLAERKTKRSRI
Protein: ADP-ribosylation factor-like protein 3 (O45379)
Organism: Caenorhabditis elegans
Function: GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular location: Golgi apparatus {ECO:0000250}.
Interaction partners:
- Protein unc-119
- Protein XRP2
- Cilia- and flagella-associated protein 36
- Phosphodiesterase delta-like protein
- Intraflagellar transport protein 20 homolog
- Rab8
- Intraflagellar transport associated protein 2
- BBSome complex member BBS1
- Polycystin-2
- BBSome complex member bbs-7
Sequence:
MGLIDVLKSFKSPSGREIRILLLGLDNAGKTTILKQLSSEDVQHVTPTKGFNVKTVAAMGDIRLNVWDIGGQRSIRPYWSNYYENIDTLIFVIDSNDKKRFDEMNIELGELLDEEKLRKVPVLIFANKQDLVTAASSEEITRKLNLDLLRDRTWHIQACSALKNEGINDGITWVASNLKPASKK