wanglab/gogpt-training-data huggingface dataset:
Protein: SLIT and NTRK-like protein 1 (Leucine-rich repeat-containing protein 12) (Q96PX8)
Organism: Homo sapiens (Human)
Function: It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:19640509}. Synapse {ECO:0000250|UniProtKB:Q810C1}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase delta
- Receptor-type tyrosine-protein phosphatase S
- Mitochondrial inner membrane protease subunit 2
- Disks large-associated protein 3
- Epsilon-sarcoglycan
- Histidine decarboxylase
Sequence:
MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD
Protein: Photosystem I chlorophyll a/b-binding protein 3-1, chloroplastic (Lhca3*1) (LHCI type III LHCA3) (Q9SY97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated, here photosystem I.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:10818090}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Photosystem I reaction center subunit III, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem I reaction center subunit XI, chloroplastic
- Chlorophyll a-b binding protein 6, chloroplastic
- Photosystem I chlorophyll a/b-binding protein 2, chloroplastic
- Photosystem I reaction center subunit IV A, chloroplastic
- Photosystem I reaction center subunit psaK, chloroplastic
- Chlorophyll a-b binding protein 4, chloroplastic
- Photosystem I reaction center subunit N, chloroplastic
- Photosystem I P700 chlorophyll a apoprotein A1
Sequence:
MAAQALVSSSLTSSVQTARQIFGSKPVASASQKKSSFVVKAAATPPVKQGANRPLWFASSQSLSYLDGSLPGDYGFDPLGLSDPEGTGGFIEPRWLAYGEIINGRFAMLGAAGAIAPEILGKAGLIPAETALPWFQTGVIPPAGTYTYWADNYTLFVLEMALMGFAEHRRLQDWYNPGSMGKQYFLGLEKGLAGSGNPAYPGGPFFNPLGFGKDEKSLKELKLKEVKNGRLAMLAILGYFIQGLVTGVGPYQNLLDHLADPVNNNVLTSLKFH
Protein: Mediator of RNA polymerase II transcription subunit 8 (Protein SETH 10) (Q4V3C1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Regulator of both plant defense and flowering time. Involved in pollen tube growth.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 19a
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 15a
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 32
Sequence:
METQPQQPPPPPVAEKLNPKLEKELNLESLKTRAVSLAKAIARILEDFDAYGRTNTTPKWQDILGQYSMVNLELFNIVEEVKRVSNAFVVLPKNVNAMNAAILPVMLSSKLLPEMETDDNAKREQLLQGVQSLPIPMQIERLKARMDMIAAACENAERVLADTRKAYGFGTRQGPSMLPTMDKGQAAKIQEQEKMLRDAVNDGKGTQLPPDQRQITTALPPHLADVLIINDAGKIALPGQSNNINNQGMMQVSGTQFVGRSAASPSGPNFDNTTSPLPYSNSPRATGMVNVPSPQHQIQQQQFQQQQQRSKLMQLPQHQQQQLLAQQQQQLRQSSMQGLGQSQIPALHDMHGQAQQKFQTSHGQHQMPYSQPMGAHQQFQARQLSGGHIQHSMSQGQLNPAMNRHLNQFSGGANSALFTSAQGSPSSQMIPNMSSMQSQTLVPRMQQFGVSGTNPQRSHSSQMLGDQMFNTSGMMQTQQTQIQQSQQQQQQQQQGGYGNMQTNQQSLQPNNMMQNAQQRHQNPQ
Protein: Tubby-related protein 3 (Tubby-like protein 3) (O75386)
Organism: Homo sapiens (Human)
Function: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.
Subcellular location: Nucleus. Cell membrane. Cell projection, cilium {ECO:0000269|PubMed:27932497, ECO:0000269|PubMed:35397207}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. {ECO:0000250}.
Interaction partners:
- Tetratricopeptide repeat protein 21B
- Intraflagellar transport protein 122 homolog
- Intraflagellar transport protein 140 homolog
- WD repeat-containing protein 19
- WD repeat-containing protein 35
- G-protein coupled receptor 161
- Intraflagellar transport protein 43 homolog
- Ankyrin repeat domain-containing protein 54
- Ras-related protein Rab-23
- ADP-ribosylation factor-like protein 13B
Sequence:
MEASRCRLSPSGDSVFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTPHSNVILHGIDGPAAVLKPDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLERPNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDSKLACE
Protein: R3H domain-containing protein (Q9N4P3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSTENDVSEENNSELDDVEDAKQDDRRRSTTVIMTMNVTTVPATESEGVRRNGSVRRRLSKQNATIEEPISLLSISDSPSENSDTTVPCIEEHPEEGKEEEKPAESSDVSKLRPPGLAQNKLWSTSKSLSRESTGTEYSDRSGIDLRNFVDRTLHKSEEDRKQLLEFEKQLKELILDDSTQSKRFELPSSYHRMLLHRCAAWFGLDHNVTNKQTDIVVNKSEKTKIPDDNFTDYIRHDNYVEDRLKRQNTCGSRKELHHMESFGDHSTSQYGSQASLNHDLLMMRRAQSFDVAAVTGPSVIQPQSPHHVRGLPMRQLSLNCPQQSMVTAPMSGPQGHQWAPQRSFDCSNNSYLCTGKHPMMRKAESFGGMANGISHGCYEQSVPVVCGTPPSVMVHHHHHHAHIQQPPTSNYTGYQVFEEMSMPSSNYQEPGMCSPGGTYYEYVPQPVVQPQQYARPIRYMPQDYRRPQGVQYMYGPPPPQQYMQYQPMVHPEVEVIVDPVQTQPFPQVSHFVLPDQQQGYSSSHQAETANSFIKASIDGGYGSMNQDVENAEKVEEV
Protein: Guanylate binding protein 128up (GTP-binding protein) (Protein upstream of RpIII128) (P32234)
Organism: Drosophila melanogaster (Fruit fly)
Function: Deformed (Dfd) is required to activate 128up in maxillary segment cells.
Interaction partners:
- Zinc finger CCCH domain-containing protein 15 homolog
- FI08802p
- RE22290p
- GEO07425p1
- FI01658p
- DNA polymerase epsilon subunit 2
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL30
Sequence:
MSTILEKISAIESEMARTQKNKATSAHLGLLKAKLAKLRRELISPKGGGGGTGEAGFEVAKTGDARVGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGCIKYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLIFMVLDCLKPLGHKKLLEHELEGFGIRLNKKPPNIYYKRKDKGGINLNSMVPQSELDTDLVKTILSEYKIHNADITLRYDATSDDLIDVIEGNRIYIPCIYLLNKIDQISIEELDVIYKIPHCVPISAHHHWNFDDLLELMWEYLRLQRIYTKPKGQLPDYNSPVVLHNERTSIEDFCNKLHRSIAKEFKYALVWGSSVKHQPQKVGIEHVLNDEDVVQIVKKV
Protein: Glutamate dehydrogenase (Q8ILT0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- glutamate synthase
- Glutamine synthetase, putative
- Aspartate aminotransferase
- Isocitrate dehydrogenase
- Glutamate dehydrogenase
- Glutamate dehydrogenase, putative
- 2-oxoglutarate dehydrogenase E1 component
- Citrate synthase
- Dihydrolipoyl dehydrogenase, apicoplast
- Dihydrolipoyl dehydrogenase
Sequence:
MSALKDKTGRFVVLDKNASNYESLVDQEMNNVYERVMKLDPNQVEFLQAFHEILYSLKPLFMEEPKYLPIIETLSEPERAIQFRVCWLDDNGVQRKNRCFRVQYNSALGPYKGGLRFHPSVNLSIVKFLGFEQIFKNSLTGLSMGGGKGGSDFDPKGKSDNEILKFCQAFMNELYRHIGPCTDVPAGDIGVGGREIGYLYGQYKKIVNSFNGTLTGKNVKWGGSNLRVEATGYGLVYFVLEVLKSLNIPVEKQTAVVSGSGNVALYCVQKLLHLNVKVLTLSDSNGYVYEPNGFTHENLEFLIDLKEEKKGRIKEYLNHSSTAKYFPNEKPWGVPCTLAFPCATQNEINLEDAKLLQKNGCILVGEGANMPSTVDAINLFKSNNIIYCPSKAANAGGVAISGLEMSQNFQFSHWTRETVDEKLKEIMRNIFIACSENALKYTKNKYDLQAGANIAGFLKVAESYIEQGCF
Protein: Thiol:disulfide interchange protein (Q9PDF5)
Organism: Xylella fastidiosa (strain 9a5c)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418, ECO:0000256|RuleBase:RU364038}.
Interaction partners:
- C-type cytochrome biogenesis protein
Sequence:
MYRLIVALLLGIVTLTACAQPSQPSSNKTSTTPTNATPANVQQRVTAALNTLDPDFKPDYIGAAPFPGFREVVVSGQILYVSDNGRYLIQAQPYDIQNKKFAVSEGLLSYRRTQLATVPQSQRIVFAPKNPQYTISVFTDIECGYCRKLHSEIAELNKQGIAVEYLAFPRMGLGSQDYKDMVSVWCAADRKQVLTEAKAGKQIQNKNCNNPVALEYSLGQRIGVNGTPAIFAPDGTQLGGYLPPEKLRALLDKLAAATAKGG
Protein: Phosphatidylinositol transfer protein alpha isoform (Q803U3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Membrane-associated phosphatidylinositol transfer protein 3
- PITP-less RdgB-like protein.
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Myosin XVIIIAb
- Nucleus accumbens-associated 1, BEN and BTB
Sequence:
MLIKEFRIVLPVSVEEYQVGQLYSVAEASKNETGGGDGVEVLKNEPYEKEDGEKGQYTHKIYRLQSKVPSFVRLLAPSSALIIHEKAWNAYPYCRTVLTNEYMKDNFLIMIETWHKPDLGEQENVHNLDSERWKQVEVIHIDIADRSQVDTKDYKPDEDPATFKSQKTGRGPLGPDWKKELPQKKDCPHMCAYKLVTVNFKWFGLQKKVEGFIHRQEKRLFTSFHRQLFCWLDRWIDLTMEDIRRMEEETQKELDKMREKDPVKGMSAADE
Protein: Dual specificity phosphatase 23 (Testicular tissue protein Li 59) (A0A140VJI5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
Protein: Enolase 2 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase 2) (2-phosphoglycerate dehydratase 2) (P00925)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm.
Interaction partners:
- Enolase 1
- Pyruvate kinase 1
- Fructose-bisphosphate aldolase
- Enolase-related protein 1
- Phosphoglycerate kinase
- Phosphoglycerate mutase 1
- Glucose-6-phosphate isomerase
- Triosephosphate isomerase
- Pyruvate kinase 2
- Phosphoglycerate mutase 2
Sequence:
MAVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRDEDKSKWMGKGVMNAVNNVNNVIAAAFVKANLDVKDQKAVDDFLLSLDGTANKSKLGANAILGVSMAAARAAAAEKNVPLYQHLADLSKSKTSPYVLPVPFLNVLNGGSHAGGALALQEFMIAPTGAKTFAEAMRIGSEVYHNLKSLTKKRYGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASSEFFKDGKYDLDFKNPESDKSKWLTGVELADMYHSLMKRYPIVSIEDPFAEDDWEAWSHFFKTAGIQIVADDLTVTNPARIATAIEKKAADALLLKVNQIGTLSESIKAAQDSFAANWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERLAKLNQLLRIEEELGDKAVYAGENFHHGDKL
Protein: Sugar baby, isoform C (Q9VTL9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Dynein regulatory complex subunit 5
Sequence:
MKATIDKELLPMKAHYFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFVPGMEKPLPKVEFHCHQGVSDIPRFCSEYGECVERNLERYYGNRTLECELNCEAQPFMWDIVCEDWLKNNTENCAANRTNTQMEFGASITMQKIENDGSCMFFMIPHDQGQIAGQNVTLYCPKEKEYFKSNCTMDCREDYLKEQLAESAVINTSSAVTMPQFWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHHLYGKQRLCGSLGWGVFALLAGLLVDHMSLGEVNKNYTAVFWMALLIMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELDKAFEGCDSSIKTLEGLVMGIQCFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHVCIQLYLQRNSNIDENGKGTVASASATASPSAPLETDIPKNTDHKDGDGFREVDLS
Protein: Chondroitin proteoglycan-2 (Cytokinesis protein B0280.5) (P41996)
Organism: Caenorhabditis elegans
Function: Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.
Interaction partners:
- Inactive protein-tyrosine phosphatase egg-4
- Chondroitin proteoglycan 1
- LDL receptor repeat-containing protein egg-1
- Chitin-binding domain protein cbd-1
- Inactive protein-tyrosine phosphatase egg-5
- EGF-like domain-containing protein
- Chitin synthase chs-1
- PUM-HD domain-containing protein
- PERMeable eggshell
- Secreted protein
Sequence:
MKTVAALTLLAFATAANGQFLQDCTNALDGLYALGECEPQFLTCSGGIARIMDCPADLIYNEPLLICDWRHNVIGCEGSGESSGETSGEGSGESSGEASGEGSGEASGEGSGEASGEGSGEASGEGSGSGEETVENVCENLEDGAYSSGGCTTYYFFCTTNTARFLSCPTPLFYDADSQKCIWKSLVEECKEDLTITDGSGETSGEGSGEASGEASGEGSGEASGESSGQGSGEASGEGSGELEPTCEGKADGIHPNGVCSTNFLTCSGGIARIMDCPASLVFNPTILVCDWPRDVAECAGLPTPQPTCEEDGYFSFGQCSSSFTACTNGRAIVMFCPAGLKFSESTVRCDYESNVSECQETSGEESGEASGEQSGEGSGEASGEASGESSGEGSGVEEQNQCVGLDNGLHAIGCSPRVLSCQNGHVDIFECPSSLVFNDQSLICDYPQTSLKCLIEDTILIDETPIAAFDCSTDGLFSDGLCSATYHQCTAGQLINFTCAASNAVFSAANTECVDSSTLLQCH
Protein: Protein c-Fos (Cellular oncogene fos) (Proto-oncogene c-Fos) (P12841)
Organism: Rattus norvegicus (Rat)
Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). {ECO:0000250}.
Interaction partners:
- Transcription factor JunD
- Transcription factor JunB
- Transcription factor Jun
- Protein FosB
- Estrogen receptor
- Fos-related antigen 1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 8
- Cyclic AMP-responsive element-binding protein 1
- Mitogen-activated protein kinase 14
Sequence:
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPSTGAYARAGVVKTMSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPNDLGFPEEMSVTSLDLTGGLPEATTPESEEAFTLPLLNDPEPKPSLEPVKNISNMELKAEPFDDFLFPASSRPSGSETARSVPDVDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
Protein: IP17501p (Omega, isoform G (EC 3.4.14.1, EC 3.4.14.2, EC 3.4.14.4, EC 3.4.14.5)) (A2RVG6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGNDVSVTETAQSDQFHLPTTANAAAHHQYYRFHKQQQQQHQHHHQQQQSCLRQQQRQLQWEQQQHQQLQHQLTNSSSEFDEFHWPSKQTGGENLGGKIYITPADIPPPPQPPHQSGSNSHSHHNGSNRQQQQHQQHPHSLHSHIHPHPHPHHQHGHRTPPHRCKCEHPSIELMGYEDSVIATATASNTAANVGVAGGGGVGRHQHPPYYYKAAVGRRSSAKLHESMLGGGSSLEDDDGTSAGSFGEGMSRFKNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFASSRLMKSAK
Protein: Shieldin complex subunit 3 (REV7-interacting novel NHEJ regulator 1) (Shield complex subunit 3) (Q6ZNX1)
Organism: Homo sapiens (Human)
Function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Subcellular location: Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}.
Interaction partners:
- Shieldin complex subunit 2
- Mitotic spindle assembly checkpoint protein MAD2B
- Shieldin complex subunit 1
- Pachytene checkpoint protein 2 homolog
- TP53-binding protein 1
Sequence:
MTTEVILHYRPCESDPTQLPKIAEKAIQDFPTRPLSRFIPWFPYDGSKLPLRPKRSPPVISEEAAEDVKQYLTISEHDAKSHSYDCTVDLLEFQPSLKKQHLTWSHTLKEQTNSGNLGKQSEKGKQHKRRSWSISLPSNNCTKNVSPLSKKLQDSLKALNLHSLYRARWTIEHTICNSQTLEDIWTKLNQIIRHNELPSCNATIQRHLGQIWVFCDIMYCEYVGSLLKGRLALTGKINLFVHKYGVIFSM
Protein: Ppfia1 protein (Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 1) (B2RXQ2)
Organism: Mus musculus (Mouse)
Interaction partners:
- Receptor-type tyrosine-protein phosphatase F
- ELKS/Rab6-interacting/CAST family member 1
- Pleckstrin homology-like domain family B member 2
- Receptor-type tyrosine-protein phosphatase S
- Protein unc-13 homolog B
- Kinesin-like protein KIF1A
- ARF GTPase-activating protein GIT1
- Receptor-type tyrosine-protein phosphatase delta
- Liprin-beta-1
- Inhibitor of growth protein 4
Sequence:
MMCEVMPTISEAEGPPGGGGSHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGLLDGNHEQESAPSTNGKRSSDGSLSHEDLAKVLELQEVIDRQAREQSQMKERLASLSSHAAELEEDLDTARKDLIKSEEMNTKLQREVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKSGPLSSGSSAAKEAKLLELTSKLRKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVENAKKQLEETQHDKDQLVVTIEALKAELEQMRLRGPSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPPGSGRSTPRRVPHSPAREVDRLGVMTLPSDLRKHRRQLPASREEVRDDKTTIKCETSPPSSPRPLRLDRMHKGAPHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGPLGKESPGQVGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTTGNVWLTHEEMETLTATPQTEDEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQNETRDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLITGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLASGSAETLPANFRVTSSMSSPSMQPKKVQMDGSVSGAQRLDSATVRTYSC
Protein: Putative glycerol-3-phosphate transporter 3 (G-3-P transporter 3) (Glycerol-3-phosphate permease 3) (AtG3Pp3) (G-3-P permease 3) (Q9SA71)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative U-box domain-containing protein 50
- Putative F-box protein PP2-B6
- Jacalin-related lectin 12
- At2g34355
- Major facilitator superfamily protein
- Major facilitator superfamily protein
- Transmembrane protein
- Receptor like protein 24
- UDP-glycosyltransferase TURAN
- Protein DETOXIFICATION 25
Sequence:
MASWTSSEFLYEEVKPPGIHFLERFRRSGKLSFKQYQAMVFVLTFIAYIAFHATRKPNSIVKGTLSEQPTGHFKGADKGGWAPFDGPDGTALLGQIDLAFLSVYAVGMFVAGHLGDRLDLRTFLTIGMVGTGVCTALFGVAFWANIHAFYYFLAIQTLAGWFQSIGWPCVVAVLGNWFDKKRRGVIMGVWSAHTSLGNIIGTLIATGLLKFGWGWSFVGPALLITFLGIVVYLFLPVNPHAVEAERDGSEVDSTMRLGDTITESFLSSRTSTGFDRRAVGFLAAWKIPGVAPFAFCLFFTKLVSYTFLYWLPFYVSQTEIGGEQLSQETSGNLSTLFDVGGVVGGILAGYFSDQLDGRAITAGGFIYLTIPALFLYRIYGHVSMTINIILMFVAGLFVNGPYALITTAVAADLGTHKSLKGNARALATVTAIIDGTGSVGAAIGPVLTGYIAAISWDAVFYMLMTAALISGLLLTTLIIEEVKTLLYGSSEEDHEVAAASTSRPPIDVLI
Protein: Homeobox protein ceh-23 (P34663)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Required for differentiation of AIY interneurons, acting downstream of LIM/homeobox protein ttx-3. Modulates gene expression, acting downstream of AMP kinase aak-2/AMPK signaling. Modulates lifespan.
Subcellular location: Nucleus {ECO:0000269|PubMed:21713031}.
Interaction partners:
- Serpentine receptor class alpha-11
- Transcription initiation factor TFIID subunit 4
- Homeobox protein dve-1
Sequence:
MDTHLPFQTLPVSTPLPVSSSSLTDVLQTIAALQACPTSCIPSTSTGMLSPNLPFSATIPRVNLFPPSQPANSLILPTIPAQPFIPNPSLLQANPSAVEALANALFATTSRRASCPEPPASSQATVTLQVPSTGSPERRRYSETNMEVLLREQLAQLMPPTSQLPGMPGCYYQHVPAAGTSGIQGSLDAALMGAVPLAMNSMAHSRRAANHRKARTIYGTTQTQQLEDMFKGQMYVVGAERENLAQRLGLSPSQVRIWFQNRRSKHRRKQQEEQQSTTLEEKSEEIGKDEEEDDEEDEDDVKVLN
Protein: mRNA export factor crp79 (Meiotic expression up-regulated protein 5) (Polyadenylate-binding protein crp79) (PABP) (Poly(A)-binding protein) (Q9P6M8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds the poly(A) tail of mRNA. Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12181330}. Nucleus {ECO:0000269|PubMed:12181330}.
Interaction partners:
- Meiotic PUF family protein 1
- Meiotically up-regulated gene 110 protein
- Poly
- Meiotically up-regulated gene 103 protein
- RNA-binding protein mde7
- Zinc metalloprotease mde10
- Copper-binding regulatory protein cuf2
Sequence:
MNNSKLSVPGQYEDESSTIYVGNIDSRLSDEEIIKHFSKYGQVESIFRRLLDSFYPKEKAKPFKPPKNGVQYGFVKFVNAESIEEVLKDAKGMTLGQRKLTIKARVVNPAKLTDKKFKPNDTSITANVFNPSIQNNTDEENVKPGLKQSQIKEFIPNVEERNWETVRGINSRNPKPETTLTIPSLGLEDISMQVVPNAFASTLPLSILNLPAEVTPIDLYNHFKQAGVVKGTAVSQFLDQRGFRYGEVIMDSVESCQNAIEKLNNVPYKGSILEVSIKNKASSSVKSIPTTPTGESLWPFPSENANKTQINIENATCSKMTWIMGSPTKEKSQWGSVSTTGVSNQQNHPAAWNPDNKPQSIVHWDSLRESSPSIPNSPIDPSNLYVKNLDDTVITCKSQLEDLFSPFGSILSSMLACYPNSGISKGYGFVAFRQIEAAVRAKDTLNGMMVGKKRIFVCFAERKSDRIRRLQAFFANKPTSEQTAQQDNKALFVKPERSSTVTIRKPIESSTNKISENPTTLSSKVENKNEPKTGENKEPSQTNEYVNCKQENKELSGQLSGNLDIKKEAGKLSHDGEQGNLLKPLVFHANTKLNNRGSAKMGSTATNLKKIQDMLHNKKLSNAYFVPRARATTCTTLTYVTVEPSHFQDEDCNESTNMLSLVGYMDSYPEATSNIQKMNSYHIKDSNKENFLSTTKVNNNSPTTIQLTQI