wanglab/gogpt-training-data huggingface dataset:
Protein: BSLF1 (Helicase/primase complex protein) (A0A0C7TRZ7)
Organism: Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
Interaction partners:
Sequence:
MSAPVVIKALVASNTDIAEAILDAILSRPDEGFRLFCLCHNASPLHHVAGSLVELQLHLPKKRLTSQSRCGLVLTLHLPAEEAFPFLRGLTPLTADRLSTYLDRAGALRSLTPLVELLTLSAKKQPQGDARGRVAWLRPKIVGCLRRIYRVNISARWFISTFGSHEAQFVLVTAAYYFWGIPCTIETLAHLTELFTSESGQSLAAVTSLAELGEVFGSSAWAEQTEAFAHFAHEKLRRDSREIRAVARTIDAYRGRLPLASADLVRYVYLAHAQCFNEGTFKRYSQLTSVGEIGCLPSGGVVLPSLLDRGFAEHMRTYFTRETYLAEHVRVQQLKIRMEPPAPYTWDPDPDDGLMRAWAGLSVDVARELVELARWHADEGPTYPPTLQGFLCLAGQATCRGQWNPKEQFLPPTVLRRVQRLPVFLCHFADRHYFVMTAADPFSSHLAEVVSTPTNCRLPDTCLTRALSYTPVYYSQNSLSEQLFVSRHEYFNPRLPVCNLVLDLDLKIKGAPWSLEEIYDLCRTVRREVLRLMRRLGPVSRAHPVYFFKSACPPADPDNMEDVLPFCICTGKLGFRVITPLPRGHAIVGTSAVQGFVSVLQKLMGLTACLRRMRHKIKEIGAPLFDSGVYHAGRCIRLPHTYKVDRGGGLSRQLRLFVCHPEEEDKHSYVKNALNIQNLLHHSLHVGWPAPKTFCYHIADDGRDYLIQRTRETLPPTVENVCAMIEGHLGLDLVAWVSSCIWPSLMSTLATAVPEDKFPQFLHVTFEQTGPNLVQVCHARGRNFACLRHTHRASSKNVRVFLVLYYTSQAITVTFMSQCFAGRCGANQPTAHFSISVPASRIINRAEASQDSTTSQLARRRDRQDGSFSETLPN
Protein: GPR158/179 extracellular domain-containing protein (Q8BFV4)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGARAVVISSLAWGLLSCCFLCSGALGSQRPLRSLPPLPSQAKPRSEPMWMPPKGAEAALAFLYSGDVQRLSGANCSEKYEVRGAEGKAGVPPVLQRAAGTLAQAANFLNMLLQANDIRESSVEEDVEWYQALVRSVAEGDPKAYRALLTFNPAPGASHLQLALQATRMGDETVLQDLSGNKVQEETPGEDLDRPVLQKRVLTNDLRSLDSPKWPRGDGYVGDIQQVKLSPPFLECHEGQLRPGWLVTVSATFYGLKPDLTPEVRGQVQMDIDLQSVDINQCASGPGWYSNTHLCDLNSTQARRMAPPSPAFIPLSYHCQSHPDLSGLQGSTK
Protein: Prolactin-2C5 (Mitogen-regulated protein 4) (Q9JLV9)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000269|PubMed:10537154, ECO:0000269|PubMed:10803597}.
Interaction partners:
- Prolactin family 2, subfamily c, member 1
Sequence:
MLPSLIQPCSWILLLLLVNSSLLWKNVASLPMCAMRNDRCFMFFEDTFELAGSLSHNISIEVSELFTEFEKHYSNVPGLRDKSPMRCHTSFLPTPENKEQARHIRYEALLKSGDMILDAWENPLDYLVSELSTIKNVPDIIISKATDIKKKINAVQNGVNALMSTMNGDEENKNPAWFLQSDNEDARIRSSYGMISCLDNDFKKVDIYLNILKCYMLKIDNC
Protein: Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Q08775)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Subcellular location: Nucleus {ECO:0000269|PubMed:35922041}. Cytoplasm {ECO:0000269|PubMed:35922041}.
Interaction partners:
- Core-binding factor subunit beta
- Histone deacetylase 4
- Transcription factor SOX-9
- Homeobox protein MSX-2
- Homeobox protein DLX-5
- Osteocalcin
- Protein c-Fos
- Retinoblastoma-associated protein
- E3 ubiquitin-protein ligase SMURF1
- Transcription factor Sp7
Sequence:
MLHSPHKQPQNHKCGANFLQEDCKKALAFKWLISAGHYQPPRPTESVSALTTVHAGIFKAASSIYNRGHKFYLEKKGGTMASNSLFSAVTPCQQSFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY
Protein: Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5) (Q6XGM8)
Organism: Hepatitis B virus (HBV)
Subcellular location: Virion {ECO:0000256|HAMAP-Rule:MF_04076}. Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04076}.
Interaction partners:
Sequence:
MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMALATWVGNNLEDPASRDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
Protein: Oocyte-secreted protein 2 (Placenta-specific 1-like protein) (Q4FZG8)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q86WS3}. Cytoplasm {ECO:0000250|UniProtKB:Q86WS3}.
Interaction partners:
- Oocyte-secreted protein 1
- Oocyte-secreted protein 3
- Membrane-spanning 4-domains, subfamily A, member 18
Sequence:
MGVSMALEVLVYLAVLVWTCAWDIDVDVSCSQDWMTVSVSAFSQNKRNPYIFADELYLGQNCRVTQIHAHQYDFIYPVSHCGIRTKVISNEIVCFETEMYFRPRNYCLELQIVPLQCSASRKSVWLMPLSTEEDPKPVKSPFMTDFEATPEELGLLNAHQAASSQNKR
Protein: T-box transcription factor TBX10 (T-box protein 10) (O75333)
Organism: Homo sapiens (Human)
Function: Probable transcriptional regulator involved in developmental processes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MAAFLSAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSSTGAQAVAEPTGQGPKNPRVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILGMDSLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVFVDPRKDSERYAQENFKSFIFTETQFTAVTAYQNHRITQLKIASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPNKASASTSKTPAWLHHQLLPPPEVLLAPATYRPVTYQSLYSGAPSHLGIPRTRPAPYPLPNIRADRDQGGLPLPAGLGLLSPTVVCLGPGQDSQ
Protein: Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18) (Q9H8W4)
Organism: Homo sapiens (Human)
Function: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}; Peripheral membrane protein {ECO:0000305|PubMed:19995552, ECO:0000305|PubMed:22816767}. Endoplasmic reticulum {ECO:0000269|PubMed:18288467}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots (PubMed:19995552). May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552}.
Interaction partners:
Sequence:
MVDRLANSEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGDMATCQPARSDSYSQSLKSPLNDMSDDDDDDDSSD
Protein: GH01576p (Q86NK4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNLINSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWPQVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQSEQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVPDSSHLDDDERTEFPYWKTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRVLTDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDYATPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQHLATTFSQVLESEEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHNITDLYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNPNRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQIDSVIHMFVELALSRLTREVQSSELRTMCLQVVIAALYYNPQLLLSILDKMSQQNNDSISAHFIKQWLHDTDCFLGIHDRKLCVLGLCTLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQEEEEDEEEEDGDDCEEALSSDEDDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQGGFAFPQTAVPTSFKFGS
Protein: Quinolinate synthase (EC 2.5.1.72) (P9WJK1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00568}.
Interaction partners:
- L-aspartate oxidase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Possible transcriptional regulatory protein NadR
- Conserved protein
- Probable nicotinate-nucleotide adenylyltransferase
- Glutamine-dependent NAD
- Nicotinate phosphoribosyltransferase pncB1
- Serine acetyltransferase
Sequence:
MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAVDVVASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLAGEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMIEIGHPGGGE
Protein: Kinetoplast DNA-associated protein (Q38AA5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRLIASVRASWFLPQMALLGAVRWGGGKALRPPVRRAREGAPTATRKAALPSGLKGVSTAMSVHRATRSRPRTPVVVNEENKRKKGGRPTAHVRSSSKDSEKRVVTRKGPTHTHAMQKIKYNKRVAAIAKLWRLQKR
Protein: Creatine kinase B-type (EC 2.7.3.2) (Creatine kinase B chain) (V9HWH2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK
Protein: Heterogeneous nuclear ribonucleoprotein A0a (F1QS28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Serine/threonine-protein kinase PRP4 homolog
- Eukaryotic translation initiation factor 4 gamma, 1a.
- Pre-mRNA-processing factor 4Bb.
- tRNA
- Serine/threonine-protein phosphatase
- Ig-like domain-containing protein.
- Ig-like domain-containing protein.
- Serine/arginine-rich splicing factor 2
Sequence:
MTAQMENQLCKLFVGGLNVQTTDDGLRNHFEQYGKLTDCVVVQNQQLKRSRCFGFVTYSSPDEADSAMSARPHILDGNNVELKRAVAREDAGKPEALAKVKKIFIGGLKDDIEEDHLRDCFSQFGAVEKAEVITDKETGKKRGFGFVYFEDNDSADKAVVLKFHIINGHKVEVKKALTKQEMQAAGSRGGGRGGRGGGRGMGRPQNGYGGRGGGYGNYGGGGYGGNDGYGGGYGGGYGGGYGGGYGDQMEGYGGGNGYNDFGSGYGQQSSGYGPMKGNYSGRSNAPYSRGGGGGGYGRGGYGGSY
Protein: Reticulocalbin-3 (Q8BH97)
Organism: Mus musculus (Mouse)
Function: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity).
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:26252542}.
Interaction partners:
Sequence:
MMWRWSFLLLLLLLRHWALGKPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDKLSPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSEEPGEEEPAWVQTERQQFREFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDEL
Protein: Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) (O14804)
Organism: Homo sapiens (Human)
Function: Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23393561, ECO:0000269|PubMed:37225986}; Multi-pass membrane protein {ECO:0000269|PubMed:23393561}.
Interaction partners:
- DBH-like monooxygenase protein 1
- Syntaxin-7
Sequence:
MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
Protein: Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) (Q9BZ29)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
Subcellular location: Endomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}.
Interaction partners:
- Cell division control protein 42 homolog
- ATP-dependent RNA helicase DHX8
- Probable ATP-dependent RNA helicase DHX37
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSEIMHEQLG
Protein: Uncharacterized mitochondrial membrane protein C800.14c (Q9C0W5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C16G5.19
- Putative uncharacterized protein C27E2.12
- Uncharacterized protein C685.08
- Uncharacterized protein PB1A10.16
- Putative amidase PB8B6.03
- Putative uncharacterized protein C23C4.04c
- Putative lysine N-acyltransferase C17G9.06c
- Fluoride export protein 2
- Probable circularly permuted 1,3-beta-glucanase P23A10.11c YJL171C
- Phospholipase D1
Sequence:
MSLVYLFQSVGILTPCGSAGAIAYITSQVLPAILIGPADVALAQWKYIYSMGKKSFPFLAIANALVQGYLSYSERKRSIFSSKLYAISALSGLCIIPFTLLFMKKDINSLQTLNPDLILKDVKATQNFRSIIHRWGFKNLFRSAFMFFSGLASIAGSIYF
Protein: Zinc finger protein 976 (E9Q981)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDALTFDDVHIHFTREEWSLLDPSQKRLYQDVMLENYRNLTTIGYNWKDHNIEEHSQNDRRYGRHERSPSAEKPYEYTQWNKAFKYHSHLQKLERNQTRDRHSEVFQHSKVHACQSTLQINKRTNTAQKPYKCNECDKAFLKLKYLRAHERTHSGKKPYECSQCGKAFLHPCYLRIHERTHTGEKPYQCNQCAKAFTLRSQLQSHKVVHTGVRPYICKQCNKAYPQQSYLRKHERTHTGGKPYICNLCDKAYSHQSNLRIHEITHTGEKPYICNLCDKAYSHQSNLRIHERTHTGEKPYICNLCDKAYSHQKYLQIHEKTHTGEKPYKCNQCDKGFAQLRYLRAHERTHTQEKTYKCNQCGKAFAQLTYLRVHERRHSGEKPYKCNECDKAFLQLKYLRLHERRHSGEKPYECNQCGKAFLHPSYLRMHERTHTGEKPYQCNECDKAFLHPSYLRMHERRHSGEKPYECNQCGKAFLQSHYLRMHERTHTGEKPYECNQCGKAFLHLSYLRMHERRHSGEKPYECNQCGKAFLYPSYLRMHERTHSGEKPYECNQCGKAFLHSSYLQMHERTHSGEKPYECNQCGKAFSHSSYLQMHERTHTGEKPYECNQCGKAFLQPHYLRKHEKTHTREKPYK
Protein: Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) (Endorpholiberin) (P01142)
Organism: Ovis aries (Sheep)
Function: Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:6273874}.
Interaction partners:
- Corticotropin-releasing factor receptor 2
- Corticotropin-releasing factor receptor 1
- Corticotropin-releasing factor domain-containing protein
- Corticotropin-releasing factor-binding protein
- Corticotropin-releasing factor domain-containing protein
- Pro-opiomelanocortin
- Pro-neuropeptide Y
- Oxytocin-neurophysin 1
- Uncharacterized protein
- Progonadoliberin-1
Sequence:
MRLPLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPLPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPLDSPAGPAKRGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIAGK
Protein: Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (Q811R2)
Organism: Rattus norvegicus (Rat)
Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Sterol regulatory element-binding protein 1
- Steroid hormone receptor ERR1
- Peroxisome proliferator-activated receptor gamma
- MLX interacting protein
- Nuclear respiratory factor 1
- Max-like protein X
- Peroxisome proliferator-activated receptor alpha
- High affinity cationic amino acid transporter 1
- Mediator of RNA polymerase II transcription subunit 13
- Peroxisome proliferator activated receptor delta, isoform CRA_b.
Sequence:
MAGNDCGALLDEELSSFFLNYLSDTQGGESGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSEFFQIDSENEALLAALTKTLDDIPEDDVGLAAFPGLDEGDTPSCTPASPAPLSVPPSPALERLLSPVSEVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPMLRSQSRPCTELHKHLTSVLPCPRGKACSPPPHPSPQLLSKEDEEVGEDCPSPWPAPASPQDSLGQDTANPNSAQVPKDDVRAMVQLIRYMHTYCLPQRKLPQRASEPIPQSCSSPLRKVPPRSRQTPKAFWTEFSILRELLAQDILCDVSKPYRLATPVYASLTPQSRTRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPARQKREEDEEEEEEEEEEEEKEDEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLATETHDLEEELGGLTDSSQGQQLPLGSQIPTLESPCESGCGDTDEDPSCPRPPSRDSPRCLMLALSQSDPLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKQDTKHSPGQDTAPSLPSPETLQLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVIRPEAALQRKVLRSWEPIKVHLEDLAHQGATLPVETKTPRREADQNCDPTPKDSMQLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRLESRGPCSDGTPSARHAKKRREKAIGEGRVVYIRNLSGDMSSRELKKRFEVFGEIVECQVLRRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH
Protein: Histone macroH2A1.1 (A0A0D2UG83)
Organism: Capsaspora owczarzaki (strain ATCC 30864)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75367}. Chromosome {ECO:0000250|UniProtKB:O75367}.
Interaction partners:
- Uncharacterized protein
- Histone H2B
- Histone H4
- Histone family protein
- Histone H3
- Histone H3
- Histone deacetylase
- Histone deacetylase
- histone deacetylase
- Histone H2A
Sequence:
MAKSKKIVAATSGSRSRSSRAGLAFPVGRVHRLLRKGHFADRIGSGSAVYLAAVLEYLTAEILELAGNAARDNRKTRINPRHIQLAVRNDEELSKLFTGVVIPSGGTLPHIWPALIPNEAKDSSTASASFNAPAKSATVKALAAAKSAGKKPAAVSSSSAAASSSSSASSSSSVAPKKPVRGFTILSKKTLHLGQTLYVVNGDLTEVRCDAVVHPTNGTMSFAGQVGGAIRAAAGAGVDAEVNSYMSEHSQLQVTKAAITSGHNLPSKWIVHVHSPNYSNAATATDALTQTIRNALTLADTKSIKTIAFPSIGSGNNHFPKHIAAQTILQAISAYFMSIMSSSIKEVYFVLFDQESINVYNAELINTN
Protein: DUF2188 domain-containing protein (Q8NPK6)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Uncharacterized protein
- SAV-6107-like HEPN domain-containing protein
- Hypothetical membrane protein
- Uncharacterized ACR
Sequence:
MTKRNITTVRTEDGWGNRRDNASRLSKSFDTQSEAIAAAKVTAQREKLEHRIQGRDGKIREANSYGNDPHPPKG
Protein: Merozoite surface protein P12 [Cleaved into: Merozoite surface protein P12, processed form] (C6KSX0)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: [Merozoite surface protein P12]: Cell surface. Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Note=Present on the surface of merozoite. {ECO:0000269|PubMed:22848665}.; SUBCELLULAR LOCATION: [Merozoite surface protein P12, processed form]: Cell surface. Cell membrane. Note=Shed from the merozoite surface. {ECO:0000269|PubMed:22848665}.
Interaction partners:
- Merozoite surface protein P41
- Merozoite surface protein P92
Sequence:
MIKLSKKYCLGISFVLYILLSVCEGHKNLTCDFNDVYKLEFHPNQQTSVTKLCNLTPNVLEKVTIKCGSDKLNYNLYPPTCFEEVYASRNMMHLKKIKEFVIGSSMFMRRSLTPNKINEVSFRIPPNMMPEKPIYCFCENKKTITINGSNGNPSSKKDIINRGIVEIIIPSLNEKVKGCDFTTSESTIFSKGYSINEISNKSSNNQQDIVCTVKAHANDLIGFKCPSNYSVEPHDCFVSAFNLSGKNENLENKLKLTNIIMDHYNNTFYSRLPSLISDNWKFFCVCSKDNEKKLVFTVEASISSSNTKLASRDNTYQDYISNSSFLTLSSYCAFITFIITSFLSFIL
Protein: Photosystem II reaction center protein L (PSII-L) (Q2LIJ4)
Organism: Oryza punctata (Red rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01317}.
Interaction partners:
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN