wanglab/gogpt-training-data huggingface dataset:
Protein: Possible arylsulfatase AtsA (Aryl-sulfate sulphohydrolase) (Arylsulphatase) (P95059)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Formylglycine-generating enzyme
- Uncharacterized protein Rv3067
- DNA-directed RNA polymerase subunit beta
Sequence:
MAPEATEAFNGTIELDIRDSEPDWGPYAAPVAPEHSPNILYLVWDDVGIATWDCFGGLVEMPAMTRVAERGVRLSQFHTTALCSPTRASLLTGRNATTVGMATIEEFTDGFPNCNGRIPADTALLPEVLAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSRGFERFYGFLGGETDQWYPDLVYDNHPVSPPGTPEGGYHLSKDIADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYERYREIVLERQKALGIVPPDTELSPINPYLDVPGPNGETWPLQDTVRPWDSLSDEEKKLFCRMAEVFAGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVAESMKLFDHLGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGIAAHGEIRDNYVNVSDITPTVYDLLGMTPPGTVKGIPQKPMDGVSFIAALADPAADTGKTTQFYTMLGTRGIWHEGWFANTIHAATPAGWSNFNADRWELFHIAADRSQCHDLAAEHPDKLEELKALWFSEAAKYNGLPLADLNLLETMTRSRPYLVSERASYVYYPDCADVGIGAAVEIRGRSFAVLADVTIDTTGAEGVLFKHGGAHGGHVLFVRDGRLHYVYNFLGERQQLVSSSGPVPSGRHLLGVRYLRTGTVPNSHTPVGDLELFFDENLVGALTNVLTHPGTFGLAGAAISVGRNGGSAVSSHYEAPFAFTGGTITQVTVDVSGRPFEDVESDLALAFSRD
Protein: Right origin-binding protein (P0ACI0)
Organism: Escherichia coli (strain K12)
Function: Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication.
Interaction partners:
- DNA-directed RNA polymerase subunit alpha
- RNA polymerase sigma factor RpoD
- Arabinose operon regulatory protein
- Curved DNA-binding protein
- HTH-type transcriptional regulator AcrR
- Outer membrane protein TolC
- DNA-directed RNA polymerase subunit beta
- Multiple antibiotic resistance protein MarR
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit beta'
Sequence:
MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKSAVALRLTARPILDIALQYRFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPLRLGEFTMPEHKFVTLEDTPLIGVTQSYSCSLEQISDFRHEMRYQFWHDFLGNAPTIPPVLYGLNETRPSQDKDDEQEVFYTTALAQDQADGYVLTGHPVMLQGGEYVMFTYEGLGTGVQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCELLIPIRR
Protein: Alternative oxidase, mitochondrial (EC 1.-.-.-) (Q9P959)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- Uncharacterized protein
- E3 ubiquitin ligase complex SCF subunit sconC
- Actin, gamma
- ZZ type zinc finger domain protein
Sequence:
MNSMSTTGPIRVAAIPKHYLQFTVRTYTRSMASAGLRYSNPPLVKKCYDQPTGKRFISSTPQSQIKDYFPPPDAPKIVEVKTAWAHPVYSEEEMRAVTVGHREAKNWSDWVALGSVRLLRWGMDLVTGYKHPAPGQEDIKKFQMTEKEWLRRFVFLESVAGVPGMVGGMLRHLRSLRRMKRDNGWIETLLEEAYNERMHLLTFLKMAEPGWFMRLMVLGAQGVFFNGFFLSYLISPRTCHRFVGYLEEEAVLTYTRAIKDLESGRLPHWEKLEAPEIAVKYWKMPEGNRTMKDLLLYVRADEAKHREVNHTLGNLKQAVDVNPFAVEWKDPSKPHPGKGIKHLKTTGWEREEVV
Protein: Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) (P31396)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative receptor whose ligand is not yet known.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Taiman, isoform G
- Ecdysone-induced protein 75B, isoform B
- Smrter, isoform G
- Hormone receptor 4
Sequence:
MYTQRMFDMWSSVTSKLEAHANNLGQSNVQSPAGQNNSSGSIKAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
Protein: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp) (Q9ZAB0)
Organism: Lactococcus lactis subsp. cremoris (strain MG1363)
Function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00444}.
Interaction partners:
- ATP-dependent Clp protease ATP-binding subunit ClpX
- ATP-dependent Clp protease ATP-binding subunit
- ATP-dependent Clp protease ATP-binding subunit ClpE
- Serine protease Do-like HtrA
- Chaperone protein ClpB
- Chaperone protein DnaK
- Chaperonin GroEL
- Transcriptional regulator CtsR
- Protein GrpE
- Co-chaperonin GroES
Sequence:
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK
Protein: ATP-dependent DNA helicase SRS2-like protein At4g25120 (EC 5.6.2.4) (AtSRS2) (DNA 3'-5' helicase At4g25120) (D1KF50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent 3'- to 5'-DNA helicase that could disrupt recombinogenic DNA intermediates and facilitate single strand annealing. Unwinds nicked and partial Holliday junctions in vitro. Anneals two single strands into a dsDNA molecule in vitro.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein XRCC3 homolog
- DNA topoisomerase 3-alpha
- Serine/threonine-protein kinase ATR
- DNA repair protein RAD51 homolog 3
- DEAD-box ATP-dependent RNA helicase FANCM
- Proliferating cellular nuclear antigen 1
- Proliferating cell nuclear antigen 2
- ATP-dependent DNA helicase Q-like 4A
- Putative helicase; 55525-51977
- DNA repair protein RAD51 homolog 1
Sequence:
MENLPPNRGMWNQEYSHGRISQSFRSAKPLLDRKRPIENAPNSSNPLPQRMKESMDTESVSHNINFNSTPLMELSANTPYKRLKPEIESYADGHPCGLRTPPPRFDLDKEIINGFQTDIYADVGSLSEAFVTPLKEPERVTLSNGCSTSSILDDDFDDSILEEIDLICEQSARKAACQTPTTSIYQTPSKDNKSSDPKASLDFRDVEKFEPDSNVKLKLDEETPTIAADPALLNSMPDECSKYMLSLNDRQRDAACSNISTPLMVIAGPGSGKTSTMVGRVLVLLNEGLLPSNILAMTFTKAATSEMRERIGKSAGKKAAKDITISTFHSFSLQLCRMHADKLQRTSEFSVYGHGQQRRAIIEAVRLYEEEKKNGSKTSVPCESGEGLNGAGAGAVCPEYAKDLSKKWQKFVTQGKASGKSPEQCRKMGNEIGAKILGNYNDILKACDALDYHDLISCSVTLLSDFPEVFKECQDTWKAIIVDEFQDTSTMQYKLLRMLGSHNHITIVGDDDQSIFGFNGADSSGFDSFRRDFPNYKEVRLIKNYRSSRHIVEAASSIIKNNTKRCQSKSISSENSQGSKITVKECHNEEAQCAYVIDKIIEITNDGSTPCCSHGDIAILYRRQVSGKVFQNAFRQRKIPFNVHGVAFYRKKVVQVILAMLKTTFSECDDASYRRVFKALLPFEKEEKKRIIEHIEKISTSRKCSFISAASDIFNAKISGTFKRSQLTQGRKVLQTLDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDGGKLLNEDNDLRSVLQYLMDDVAEFISTHCTTTEEEDAIKEKKGCNQLHSFINYISERETENFRSRRRDNENSVTLTTIHQSKGLEWDIVFIVKANENEIPLLHESNGNASESGTSLEEERRLLYVAMTRARKKLFFLYVTVDSNWQVLQPSRFLKEIPGHLLQGDMSVNDCRKVHENLPNKTEQSVSSFGTDIKHEESKLTDNDVMNIPEDYASEESIAAYALNGNNFLKRFDVEVRSVVSHLFHNWAKKQAFQEPKRLIDKVRFVIGERLAIKKNKHKDVLRALKSSLTSEEAFQYAEHVLRWEQLPADTRAHIVREKQEHFQKLRIENSMGTSEATSKQIAFLHSLGCTVVPTSRLHASRLIEQYKSL
Protein: Brain-enriched guanylate kinase-associated protein (Q68EF6)
Organism: Mus musculus (Mouse)
Function: May sustain the structure of the postsynaptic density (PSD).
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- WD repeat-containing protein 25
- Disks large homolog 4
Sequence:
MEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQQRVSLHMEKHGCSLPSALCHPAYADSVPTCVIAKVLEKPDPGSLSSRMSDASARDLGYRDGVEKSGPRPPYKGDIYCSDPALYCPDEREHARRPSVDTPVTDVGFLRAQNSTDSAAEEEEEAEAAAFPEAYRREAYQGYAASLPTSSSYSSFSATSEEKEHAQAGTLTASQQAIYLSSRDEFFNRKPSATYGSGPRFAKAASTLGSPLEAQVAPGFARTVSPYPAEPYRYPASPGPQQALMPPNLWSLRAKPSGNRLAGEDIRGQWRPVSVEDVGAYSYQAGAAAGRAASPCNYSERYYGGGGGGGAAGGGSPGDKAEGRASPLYATYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPSRSADALAGYAASDGDGDRLRVQLCGAGSSPEPEHGSRESLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN
Protein: RNA-binding protein, putative (Q57WA3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRGRGRGSMRFFGDRGGMERGAGSFRGRGGSRSMGGRGFSRGAGTSRGGNNTGYTATKHNEPLDGSGRNSKTDNNKFSTNDKSIAGKAVDKRPVPSQTQRVVTTVTENGTELPKKLNTKVFVDGLPYENEVKSSSLSVEEELMQFVIAWKVGKPLRLIKKDGQGFGFLVFQSPHSVDVAVRVLNGRKFLGRSLRVEVPKPRDMEGAGGSYGANDSGKCSYARQVLLSDLAKVAQPEIIREILRDVAPQLEKRLDSIKMTSKNRKAFLTFQSSEDVEAAVKFLDGFSMFGRRISAAQAAAPGSLPYSKAPIRSTALHAAEGVLVGDGDADMVAAAGPNHGDEGELVVPLGLDVPPANRPVKGMEKRKPAPAAAAKPNALPSNITGVTEKYNLLDNGPAEVFVGNLGEDVTEEQLKAHFSVCGKINSCKIIVNKNTRLPTGIASIVFAIPAYAAYAQKHMHGSCLRGHVLRVDRGEEASAPLVSELPPRDDEETIDEDGYMEHFGVTNKKEYFKGTSFEEKPGCGKKRARDSEAGGEKRKGKGKKNKGEPPKKASSPKTSHGCGTNGSHHSRGDDDDDDDEEHFFDVDEGDNVRAKPTGKQKNTKKGAPVPRKGVKKKGKGKKSS
Protein: SWI/SNF complex component SNF12 homolog (Q556Z0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Actin-like protein 6A
- PB1 domain-containing protein
- Myb-like protein X
- Myb domain-containing protein
- CHE group protein
- Bromodomain-containing protein
- Histone H4
- Myb-like protein H
- Calcium-binding EF-hand domain-containing protein
- Putative uncharacterized protein DDB_G0289263
Sequence:
MSKNGTTGNKKKKTKLSTAATIAANIAKANATLNNNNNSNNNSNNTNIGNSINGIPSSLPPSVTLPVEELISFAPECLLFSQLLEFEEKLDASINKRLIDIQEASRRNSIKNIRTLRLSIYNTYSNQSAYYHLDNKSLNSVQERPSWSLRVEGKLLDESQDELVNKSIKSSSSSSSTANKRKFSSFFKKVFIQIGHRDTCEWDKSQTFTETDGFEIKRNGNQEVDIKILMYLDHVPQKYKVLGGLSQLLNIHTDTKPRIILALWHYIKSNTLLDAETKKITCDENLKNIFSLEELQFNQIPQLLREHLSPPDPLEFQYTLHLSGDAKDYEQAYDIQVEVDEPIFNPNPTMRKEISQLNDEINHHIQKVYQHKRKREFMEKLSSDPLGFLNDTTANLVKDFQVSKSTTSTGFEEERHASFYYQPMTEELVKNYLSKQTTPNPTPQQISMAPSTPQTP
Protein: Possible oxidoreductase (O69708)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible oxidoreductase
- Putative diacyglycerol O-acyltransferase Rv3740c
Sequence:
MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYNPWDQRLCAVPDADMFKAIRDGRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRTRAHHLLSAAARSHADPAAAGRRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRITRSTPWN
Protein: Uncharacterized protein, isoform H (A0A126GV26)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRGLVEDTKRTKLSSANNNNLSSTSGSGRIKSSSLATGSSASGSSSKPLRSAVKTPTSGSATSLSSGTMAAKKAPQTGQQQVGKSAKSATAATPTGTTATAIGATATTRAQAAAAKSQKGQNPPSQQVQPKQQPPQPQQTQQQPLVLQQQQASNSSNTIALPKASHANTSEELAGGVQDTIYLCNFRVSVDGEWLCLKELQDIDVAGGTGNQAAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSKRFSGLSTGSGSGGNAGGGGGLDITDNARDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQKRNTNRSSSTSNTMDQDRDRALEQELELGTEPLAETDRRTRGDSRIWKSSRRSPRSTNRTLARP
Protein: Actin-binding LIM protein 1 (A0A8I6ABC6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVKEKVAHPQDPHHSSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKEATCSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGSPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQDRQSLGESPRTLSPTPSAEGFQDGRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQNKASEDIIKFSKFPAAQAPDPNEIPKIETDHWPGPPSLAAIGTDPRRRSSGREEDEEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKENRERASLLASRYDSPLHSASHAPSSKTSSLPGYGKSGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILRDVDRTRLERHLAPEVFWEIFGMSIQEFDKLPLWRRNDMKKKAKLF
Protein: MAD (Yeast Mitosis arrest DeFicient) related (MDF-1) (G5EFM0)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD2A
- WD repeat-containing protein fzy-1
- Mitotic checkpoint protein bub-3
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- BUB1 N-terminal domain-containing protein
- Origin recognition complex subunit 2
- Centromere/kinetochore protein zw10 homolog
- Fizzy-related protein homolog
- G2/mitotic-specific cyclin-B3
- Abnormal embryogenesis protein 30
Sequence:
MNYDEDIVDEDEYEESEATMLFAEEIKKQFKREFPLKAETEKKLKQATFRRHAPVEARKINFDMTLSPVAPIELASAKKEKESAQRQLVTLREDHERMKQMMQTNQAKLAEKTIDLETNREKMLELQEQVELLKQERDDTIAECNRNVDIWTAFGKKYYTWYSMANTQLESVKLYIDNDGKFENDEEVTRLNAVPRQMYRALEQFDYDDETVEELGSGSLLEYEGVSFATRRPPSPETEREIARADQSAANFTLPQSNFTLLEDSNNTIMPEDQTMMTDGCIANRSLIDYEKDEKIQRLLLENSVLKDRLNVSSGRAERSMIFEERNRTLEFEKKALHKQLDSTFSEIEAIRIGQAGNLFNIDEKIPSSSDNSAKQLQLIDRITQLITKNNQLEKDFEAATSRMTKVMRESTDCARRNERLEDAFSSERVRSQDLENEKSRLSEQLELSNNELEKVKKQLEESQSQLDEVLSMTLTVPASEPASLPAPTDAGNSTQIFHMASNPLQDAHNEFQASESRKRKLTDAPAGDQWREQEFAELEKRLYDCESEKKVLESSYNLHKELSSKFRQVCIALTGLQIKLKDADEGICTVQSEYEGGSAQQFVFKYFYGTPRIDMLDVSCESTTEMLRKWEPLMKKYIGDRNSIPAFLAAMTLQLEQDRDFDETMHERTHTFSVLHED
Protein: DNA polymerase subunit delta-2 (EC 2.7.7.7) (P87324)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression.
Subcellular location: Nucleus.
Interaction partners:
- DNA polymerase delta catalytic subunit
- DNA polymerase delta subunit 3
- DNA polymerase delta subunit 4
- DNA polymerase zeta catalytic subunit
- DNA polymerase zeta processivity subunit
- Proliferating cell nuclear antigen
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon catalytic subunit A
- Flap endonuclease 1
- Replication factor A protein 2
Sequence:
MVEVRHSIPCEETKRLELSLSQQTYSQQYASIYFARLTALRPRITEAASKKWPDKQRLERVLDVKSDEDCWVVATAYMTTALKPNVMNDVTQLHTIVTTTEESPYVSPEDAASGDIEYALEDDYGRIDCSGSFLYDAGVVTGVVLAVLGHEDEQGRFVVVDVCFPGIFSHSIPMTTDESQAQPEYIAAVSGLGLSNDGIEGIQVHQLVDFLRGTLPHVSSFSPSSIKRLIILGNCLAPSIEIADSASASVPIGKKKVKRYGYDTSAYNPNPTFQLDNFLDQVCSSIDVTLMPGPYDYSSTILPQQPLHPALLTKSKVWLGSSLQTVTNPTWLSLGNHFVLATSGQNINDLRKYHPKKSSLQCMENTLLWNHITPTSPDTLWCYPFTDKDTFVMEEMPDLYLCGNQPKFGCKTVINEGNRIQLVSVPEFRKTGVLVLINMHTLNVEIIQFRPMSVKAETPITS
Protein: WD repeat-containing protein 5 homolog (Q54KL5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone-lysine N-methyltransferase set1
- Histone H3.3 type c
- Histone H3.3 type a
- Histone H3.3 type b
- Nuclear exosome regulator NRDE2
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
Sequence:
MESGPASMSSSSSYLYQEQQQQQPQQTESIPQTPNYILKYTLKGHLKSISSVKFSPDGKWLASASADKTIKIWGAYDGKFERTLEGHKEGISDIAWSQDSKLICSASDDKTIKIWDVESGKMVKTLKGHKEYVFGVSFNPQSNLIVSGSFDENVRIWDVNTGECTKMISAHSDPVTGVHFNRDGTLVVSGSYDGTVRIWDTTTGQLLNTISTEDGKEVSFVKFSPNGKFVLAGTLDNTLRLWSYNNNKKCLKTYTGHKNEKYCIFSTFSVTCGKWIVTGSEDNLIYIYNLQTREIVQTLAGHEDVVLTVACHPTENIIASGALEKDRSVKIWKHM
Protein: HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) (O60381)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10562551}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
- E3 ubiquitin-protein transferase RMND5A
- Glucose-induced degradation protein 8 homolog
Sequence:
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
Protein: Sushi domain-containing protein 4 (Q5VX71)
Organism: Homo sapiens (Human)
Function: Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
Subcellular location: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:23482636}.
Interaction partners:
Sequence:
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIADEIPLMEEDP
Protein: Cleavage stimulation factor subunit 3 (A0A096MJQ0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGDAAAEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDARTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFREEYEGKETALLVDRYKFMDLYPCSASELKALGYKLQACTRSPGECSRCLQPPLF
Protein: Uncharacterized protein (Q382B8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR017179}.
Interaction partners:
- Piwi-like protein 1
Sequence:
MSFLVYAVDGADRLTLLGPPTPEGPNLKQVALSYIQAPKVAKRNATGEFGSEDPCAFEAVELIRNTFIGKPVKFSEDYVIDVLQRRAGRLTLVDGEDASILLLRNGLATVPERIPQRMDKELFAKYTKLMSEAKAAKKGIFAPSASSRVRTLTDLSPEEKIKLAEKLKGKEALVRLEHVLLPTVLVVSGGDFGDAQVTVHMPGVTVKDPDCETVSRESRYHVERFLLHRRVKILFEGADGYGNILGSVTSSKGCFQQELLSRGLVKLNGNTLGSTKFAADMETAEKEAREKCVGMWKNRGESGARVPLKVVGGAGVSTAAATGGSSALPVSNAATAATVVYKGPTQFTASIVQIITGDTLGVRHEESGELIRVSLAGVRSSKNITREQDGRSPETRVTYGDYEWEAREFLRVHFAGKRVTVKVEYCRQIAETGEVRPVALITVLETGENVGSALLETGYVNFFLGRNDICSAAAELQCASERAEAKGVGVHGKAPAPVVKVLELVHLGSARGKYYLSFLQRGMQGNRPPVLKGIVDVVIGGSSLRVFVPREHFQIPVKVAGIITPMGAAGGSSEGGEPFAEESKRFAVDKLQHMEVGIQVHAADKVGNFISSVTLPDGTNFAVAMVEMGFATVANADRLPHNQQLLEAEAKAKAEKRNIWSNNSSVPQRAAKLEAQKIRTGPIRYTSSSGPKAEFQQYMLSEVGENGYSVYLQEATEDVEKKLFTMQDLLGQISSSSTEYKPKKGELVAALYKTDKTWNRAKVVQVSKKDPTVTVCFVDFGTKSEIRLKDVRAIPRGPEFAIARDSAPLARLVRLAFLKSKIHTEAYIDYACDIAYEYTDGPVVAKEVYQDPEGNVYCIVSTSENSNSLNEVLLQRGAAVLDRAAESVDPEGHKRHVTAQNVARKGHKGMWQYGDIDNESDEDN
Protein: Claudin (Q6NUZ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction {ECO:0000256|RuleBase:RU060637}. Cell membrane {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU060637}.
Interaction partners:
- Tight junction protein 1a
- Occludin
- Endothelial cell adhesion molecule a.
- Tight junction protein 3
- Cadherin 5
- Claudin-11b
- Junctional adhesion molecule A
- Claudin-7-A
- Claudin 18
- Claudin
Sequence:
MASAALELLGLILCVCGTLLEMVACGLPTWKVTAFIEANIVVAQTIWDGLWMSCAVQSTGQMQCKVHDSMLALSHDLQAARALTVISSVLSVLALMVVIAGAQCTNCIKEDNVKARVVNVGGVIYILSAIFVLVPLCWMANNIISDFYNPQVLPAQKREIGAALYIGWAASALLLLGGSILCCSCPASGSSGYSVKYAPTKRATSNGEYDKRNYV
Protein: Agmatine deiminase (EC 3.5.3.12) (Agmatine iminohydrolase) (Protein EMBRYO DEFECTIVE 1873) (Q8GWW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the hydrolysis of agmatine into N-carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine.
Interaction partners:
- N-carbamoylputrescine amidase
- Arginine decarboxylase 2
- Arginine decarboxylase 1, chloroplastic
- Spermidine synthase 1
- Spermidine synthase 2
- Spermine synthase
- Thermospermine synthase ACAULIS5
- S-adenosylmethionine decarboxylase proenzyme 1
- Agmatine coumaroyltransferase
- Arginase 2, chloroplastic/mitochondrial
Sequence:
MEESRESPAEHGYYMPAEWDSHAQTWIGWPERQDNWRHNALPAQRVFADVAKAISKFEPVTVCASPAQWENARKQLPEDIRVVEMSMNDSWFRDSGPTFIVRKRPVKLSSLNRNIAGIDWNFNAWGGANDGCYNDWSHDLLVSRKILALERIPRFQHSMILEGGSIHVDGEGTCLVTEECLLNKNRNPHMSKEQIEEELKKYLGVQSFIWLPRGLYGDEDTNGHIDNMCCFARPGVVLLSWTDDETDPQYERSVEALSVLSNSIDARGRKIQVIKLYIPEPLYMTEEESSGITQDGEAIPRLAGTRLAASYVNFYIANGGIIAPQFGDPIRDKEAIRVLSDTFPHHSVVGIENAREIVLAGGNIHCITQQQPAEPTSVAENGH
Protein: E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia, complementation group L) (Q6NY39)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSCLLMRESPLIIALNKEKTLYDGFITVLEKDFRIRISLPPDHQMKRAKLHCCWQMKRLLHGYQHIVKQRLQHSTTLMAFILELRTVLEVALKSQPGCQSFSPPQYYSQLITEMEILGWDKLLFIDAEFRTLQLKAEDSAGRQHAITVKLKSKYPAEAPEFSADLPIPLVITWTSQSTLANVHSQFLLNVEALSDFWSVLDEIDEKTWVLEPEKPTKADSTRRIAIGNNVSIKVQIDPRHPKMLPECCLLGAEHVVTPLRNKLNANMHLWNPDCTVLQNMKDVLEIEFPSPTTHEKSSFSVECGICYSYRLESAIPDQVCNDPRCGQPFHQVCLYEWLRGLPTSRQSFNIVFGECPYCSKPITVKMVTGNA
Protein: Mitofusin-1 (EC 3.6.5.-) (Transmembrane GTPase MFN1) (Q811U4)
Organism: Mus musculus (Mouse)
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:12759376}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitofusin-2
- E3 ubiquitin-protein ligase parkin
- Dynamin-like GTPase OPA1, mitochondrial
- Mitochondrial antiviral-signaling protein
- Serine/threonine-protein kinase PINK1, mitochondrial
- Non-selective voltage-gated ion channel VDAC1
- Mitochondrial fission 1 protein
- Sequestosome-1
- Dynamin-1-like protein
- Mitochondrial Rho GTPase 2
Sequence:
MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIASEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPSEARNRIFFVSAKEVLNSRKHKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLESELENFSKQFLHPSSGES
Protein: Osmotically-inducible protein Y (P0AFH8)
Organism: Escherichia coli (strain K12)
Subcellular location: Periplasm.
Interaction partners:
- UPF0337 protein YjbJ
- UPF0391 membrane protein YtjA
- Uncharacterized lipoprotein YbaY
- Peroxiredoxin OsmC
- Potassium binding protein Kbp
- Osmotically-inducible putative lipoprotein OsmE
- Trehalose-6-phosphate synthase
- Uncharacterized protein YqjD
- Catalase HPII
- RNA polymerase sigma factor RpoS
Sequence:
MTMTRLKISKTLLAVMLTSAVATGSAYAENNAQTTNESAGQKVDSSMNKVGNFMDDSAITAKVKAALVDHDNIKSTDISVKTDQKVVTLSGFVESQAQAEEAVKVAKGVEGVTSVSDKLHVRDAKEGSVKGYAGDTATTSEIKAKLLADDIVPSRHVKVETTDGVVQLSGTVDSQAQSDRAESIAKAVDGVKSVKNDLKTK