wanglab/gogpt-training-data huggingface dataset:
Protein: UPF0304 protein YfbU (P0A8W8)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Hexitol phosphatase A
- Putative electron transfer flavoprotein subunit YgcR
- Uncharacterized transporter YfbS
- Autonomous glycyl radical cofactor
- FKBP-type peptidyl-prolyl cis-trans isomerase SlyD
Sequence:
MEMTNAQRLILSNQYKMMTMLDPANAERYRRLQTIIERGYGLQMRELDREFGELKEETCRTIIDIMEMYHALHVSWSNLQDQQSIDERRVTFLGFDAATEARYLGYVRFMVNVEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
Protein: Tuftelin (O08970)
Organism: Mus musculus (Mouse)
Function: Involved in the mineralization and structural organization of enamel.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P27628}. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites. {ECO:0000250|UniProtKB:P27628}.
Interaction partners:
- Ameloblastin
- Amelogenin, X isoform
- Enamelin
- Tuftelin-interacting protein 11
- Kallikrein-4
Sequence:
MNGTRNWCTLVDVHPESQTAGSVDILRLTLQSELTGDELEHIAQKAGRKTYAMMPGHSSGHSLASELVESHDGHEEIIKVYLKGRSGDKMTHEKNIDQLKSEVQYIQEARNCLQKLREDISSKLDRSPGDPLRQQEIQVVLEKPNGFSQSPMTLYSSPPEVDPSMSEDVESLKKTVQELLVKLREAERRHQSDRVAFEVTLSRYQREAEQSNVALQREEDRVEQKAAEIEELQRRLLGMEAEHQALLVKVREGEMALEELRIKNADCQTEREKSAALEKEVAGFREKIHHLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQVSHGNFSTQARAKTENLGSVRISKPPSPKPMPLIRVVET
Protein: Protein X1 (Sars3a) (J9TC74)
Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV)
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004598}. Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MDLFMRFFTLGSITAQPVKIDNASPASTVHATATIPLQASLPFGWLVIGVAFLAVFQSATKIIALNKRWQLALYKGFQFICNLLLLFVTIYSHLLLVAAGMEAQFLYLYALIYFLQCINACRIIMRCWLCWKCKSKNPLLYDANYFVCWHTHNYDYCIPYNSVTDTIVVTEGDGISTPKLKEDYQIGGYSEDRHSGVKDYVVVHGYFTEVYYQLESTQITTDTGIENATFFIFNKLVKDPPNVQIHTIDGSSGVANPAMDPIYDEPTTTTSVPL
Protein: Ephrin-B1 (CEK5 receptor ligand) (CEK5-L) (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) (Stimulated by retinoic acid gene 1 protein) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] (P52795)
Organism: Mus musculus (Mouse)
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (By similarity). Can also bind EPHB2 and EPHB3. Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7929389, ECO:0000305|PubMed:10704386}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:10197531}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000269|PubMed:10197531}.; SUBCELLULAR LOCATION: [Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000250|UniProtKB:P98172}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Ephrin-B1 intracellular domain]: Nucleus {ECO:0000269|PubMed:19515908}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000269|PubMed:19515908}.
Interaction partners:
- Ephrin type-B receptor 1
- Ephrin type-B receptor 6
- Ephrin type-B receptor 2
- Ephrin type-B receptor 4
- Ephrin type-B receptor 3
- Cytoplasmic protein NCK2
- Ephrin type-A receptor 4
- Ephrin type-A receptor 1
- Regulator of G-protein signaling 3
- Ephrin-B2
Sequence:
MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNKPHQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQEEKSGPGAGGGGSGDSDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGGSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Protein: Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) (P24530)
Organism: Homo sapiens (Human)
Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28236341}; Multi-pass membrane protein. Note=internalized after activation by endothelins. {ECO:0000269|PubMed:28236341}.
Interaction partners:
- Endothelin-1
- Endothelin-3
- Endothelin-2
- Endothelin-1 receptor
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Angiotensinogen
- Guanine nucleotide-binding protein subunit alpha-13
- Kininogen-1
- Guanine nucleotide-binding protein subunit alpha-12
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
Protein: Inner membrane complex protein (Q8I3N7)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MENFHLHSMIKMNSTVSLLFGIFLTVIGSIFMAIANTFMKLGLSDSKKKKYMFTNYSCDMKWYIGFIVYCFGSFLHIIALGFAPASTLAPMNSFGLIANAIVANIYLNEKLGKIELISTFGIFFGISICACASFLCETEKVHFNPIHIIESWKNPWYIFYIFVSIFLSFFTLIYLNHEENKIISENEEIYAAKRYVELNVMDEKKPETEDENISSLINSKNITDSANVYPKTIGLAYGFLAGLIGSQCVLEIKEIVAFLHIGLNNKHIYRTPLPHLCFVFLVISIYLQIHFLNVGLTRGEATLVVPTYYVFWTFFGTLGGLVKFNEIENFNFNSIILFLAGFLLTVLFISILAVQEITFLRKYVDKEVPDLPLENLDIHTQVLQNKKLSKQVILNMGLFPVSLLGTTVGRKKFRPLYERFRRTRSILSDTHIGDQHCEYSIDNNIYNAYTLPYDIYNTNTDTFSTKKKKYRHTEPRIENTYIF
Protein: NAD(P)H quinone oxidoreductase YCP4 (EC 1.6.5.2) (Flavodoxin-like protein YCP4) (FLP YCP4) (A0A1D8PT03)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:26325183}; Peripheral membrane protein {ECO:0000269|PubMed:26325183}.
Interaction partners:
- NAD
- NAD
Sequence:
MKIAIIQYSTYGHITQLAKAVQKGVADAGYKADIFQVPETLPQEVLDKMHAPAKPTDIPIATNDTLTEYDAFLFGVPTRYGTAPAQFFEFWGATGGLWANGSLAGKPAGVFVSTSGQGGGQETTVRNFLNFLAHHGMPYIPLGYANAFALQSSMEEVHGGSPYGAGTFANVDGSRQPSTLELEIAEKQGEAFVKSATKLVKGSKKTNTTTTSKSAATSDAAGTTSGTAAGTSAATGAATGTSAPKESTKEASSSAKKEATNGTATRTQQSTKAPETAEKSSCSKCIIM
Protein: Ribosomal protein L11 methyltransferase (L11 Mtase) (EC 2.1.1.-) (Q84BQ9)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: Methylates ribosomal protein L11. Preferentially recognizes free L11 before its incorporation into 50S subunits. This function is dispensable for growth and thermostability.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00735}.
Interaction partners:
Sequence:
MWVYRLKGTLEALDPILPGLFDGGARGLWEREGEVWAFFPAPVDLPYEGVWEEVGDEDWLEAWRRDLKPALAPPFVVLAPWHTWEGAEIPLVIEPGMAFGTGHHETTRLALKALARHLRPGDKVLDLGTGSGVLAIAAEKLGGKALGVDIDPMVLPQAEANAKRNGVRPRFLEGSLEAALPFGPFDLLVANLYAELHAALAPRYREALVPGGRALLTGILKDRAPLVREAMAGAGFRPLEEAAEGEWVLLAYGR
Protein: Cold-inducible RNA-binding protein A (Cold-inducible RNA-binding protein) (XCIRP) (Cold-inducible RNA-binding protein 1) (XCIRP-1) (Glycine-rich RNA-binding protein CIRP-A) (O93235)
Organism: Xenopus laevis (African clawed frog)
Function: Cold-inducible mRNA binding protein. Acts cooperatively with elavl1/elrA to stabilize AU-rich sequence (ARE)-containing mRNAs by binding to them and inhibiting their deadenylation (By similarity). Essential for embryonic gastrulation and neural development, acting to maintain the expression of a set of adhesion molecules and cell movement during embryogenesis. Plays a role in the specification and migration of pronephros cells during embryonic kidney development.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm. Predominantly cytoplasmic in oocytes. Translocates from the nucleus to the cytoplasm upon arginine methylation (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MSDEGKLFIGGLNFETNEDCLEQAFTKYGRISEVVVVKDRETKRSRGFGFVTFENVDDAKDAMMAMNGKSVDGRQIRVDQAGKSSGERRGGYRGGSSGGRGFFRGGRGRGGGDRGYGSSRFDNRSGGYGGSSGSRDYYGSGRSQGSYGDRSGGSYRDSYDSYATHE
Protein: mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) (Q9NPI6)
Organism: Homo sapiens (Human)
Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:16364915}. Nucleus {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250|UniProtKB:Q91YD3, ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:16364915}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX6
- Proline-rich nuclear receptor coactivator 2
- Protein PAT1 homolog 1
- 5'-3' exoribonuclease 1
- Enhancer of mRNA-decapping protein 4
- Enhancer of mRNA-decapping protein 3
- m7GpppN-mRNA hydrolase
- Regulator of nonsense transcripts 1
- mRNA-decapping enzyme 1B
- Protein LSM14 homolog A
Sequence:
MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIPVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
Protein: Ribonucleases P/MRP protein subunit pop1 (EC 3.1.26.5) (Q9UTA4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable ribonuclease P protein subunit 3
- Ribonuclease P/MRP protein subunit POP5
- Probable ribonuclease P protein subunit 1
- Ribonuclease MRP protein subunit rmp1
- Ribonuclease P protein subunit rpr2
- Ribonucleases P/MRP protein subunit pop3
- Uncharacterized protein C16C4.19
- Ribonucleases P/MRP protein subunit POP7
- Uncharacterized protein C6C3.09
- Probable ribonucleases P protein subunit pop8
Sequence:
MKRSTGGTQPKGLNVKRSKLADARFIEVESPALSNGAVDLKKFIESRSFEITALQDAMKRSKESSAQRAFQALPRCLRRRAASHNIKRIPKGLRDRALYEMQLSSSSTLPIAPSRQRLKRFIKRLRRKLAKSGETKAIDSTGSLVTDNSTDDSRIPSLAAVKLIRGKFAGRQLRKVWLPTHLWVCKRAHMINAWGYAIPEKPTEKSYRPTHRAAFRKDAIAFDMSYEPLFCISGPYEALKEKFGNSFANGLPPVFLNSSRSFTSYLVKSDIHELICPCFLQWNNPTEDDKKQIPVKNPTECVQLVIRLHPSAFLQAWNYLSGIAVLDDRIAMHDWRLDLASFDIHGPDSNIMLHKVFDDVELDEAGKVWQSISNYSSACLPMGASISVKALVNTRCDKNLSEKGEKSLLDSAENSLPASANQYSTHFRYWERQEIPSFAVFENKNRHTHEKKSSEKEVIPVYITYRKEWNGLTVILPWDYAKFVWRKMMYQKGIRFGGLENLHQIAFEKRMPFFPIDYPDTISGQLCEEERKKRNEDSWKRRPPAKRVNYQKFGDNFSEIGNPFCCDWVYLNEMVKASRDEDKTLQLVRVQVQLVQRGSLQDRARIYCLSDDELSKWKTIIYKENLTAENLLYPKCPNETAIIGFVTTGNFNLNAGKPSGIANVLAKTIKNEKSGYCIIRNVGCSVPRLAQWKFNQSH
Protein: Glycine/sarcosine N-methyltransferase (GSMT) (EC 2.1.1.156) (Q9KJ22)
Organism: Halorhodospira halochloris (Ectothiorhodospira halochloris)
Function: Catalyzes the methylation of glycine and sarcosine to sarcosine and dimethylglycine, respectively, with S-adenosylmethionine (AdoMet) acting as the methyl donor. It has strict specificity for glycine and sarcosine as the methyl group acceptors.
Interaction partners:
- S-adenosylmethionine synthase
Sequence:
MNTTTEQDFGADPTKVRDTDHYTEEYVDGFVDKWDDLIDWDSRAKSEGDFFIQELKKRGATRILDAATGTGFHSVRLLEAGFDVVSADGSAEMLAKAFENGRKRGHILRTVQVDWRWLNRDIHGRYDAIICLGNSFTHLFNEKDRRKTLAEFYSALNPEGVLILDQRNYDGILDHGYDSSHSYYYCGEGVSVYPEHVDDGLARFKYEFNDGSTYFLNMFPLRKDYTRRLMHEVGFQKIDTYGDFKATYRDADPDFFIHVAEKEYREED
Protein: Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] (P43322)
Organism: Rattus norvegicus (Rat)
Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons.
Subcellular location: [Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active.; SUBCELLULAR LOCATION: [Neuregulin-1]: Secreted.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-3
- Receptor tyrosine-protein kinase erbB-4
- Receptor tyrosine-protein kinase erbB-2
- Receptor protein-tyrosine kinase
- Neuregulin 4.
- Pro-epidermal growth factor
- Uncharacterized protein.
- Pro-neuregulin-2, membrane-bound isoform
- Pro-epidermal growth factor
- Probetacellulin
Sequence:
MSERKEGRGKGKGKKKDRGSRGKPGPAEGDPSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPENIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEFITGMPASTETAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLIKCAEKEKTFCVNGGECFTVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYMTSRRKRQETEKPLERKLDHSLVKESKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQSLRSERSNLVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESVISESNSVIMMSSVENSRHSSPAGGPRGRLHGLGGPRDNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHNPAHQSTSLPPSPLRIVEDEEYETTQEYESVQEPVKKVTNSRRAKRTKPNGHIANRLEMDSNTSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFSTQEELQARLSSVIANQDPIAV
Protein: Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Lysosomal cytochrome b) (F5H1Q2)
Organism: Homo sapiens (Human)
Subcellular location: Late endosome membrane {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004155}.
Interaction partners:
Sequence:
MVSGRFYLSCLLLGSLGSMCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLKNTTRPYHSLPSEAVFANSTGMLVVAFGLLVLYILLASSWKRPEPGILTDRQLLLQLRPGSRPFPVTYVSVTGRQPYKSW
Protein: Smog, isoform E (M9NDF0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MELCIATKSKIETAQSSMPQSSQCSSSSNCRNYQKKCHQNQTNTQVQSTQRSNCSSHSDRDHLTNQQKQQNQRTNSATAASAAAATLSESTRCNIIISSSSSSSSSTKSSKNIREPSSSSSTQLNTLYSLLVLLIVGLATATASPSPSPSHAPFGRESRRDALLAYYKRAHLPQSSSSGISLGHKYHLLHDANGLDFDELTPTASSVSALSRAERFRLRKRSATPTTPATAAGVTSLDVATAAAAATDAAAKDAGSGKKPEEKCEPKVLETLPDEPFYDYTDIAEDAARQFIEFLSGKFPNANTPIAIDEPTRAEVSRRANGIASYALNEDDNLLAFAIAAPSIHTVVVKFRDNVTIPPDQVHNKAYLGSYWRELGAAWNSTDGTQEWGAPFRDCNLLTRRWLWPFRISFSEHRIKVVAAAFIAADEDVCNDGLEEVFGRRHGCDRNTTFCLLTENKPAATRDVYTCLCRESYYLPNSTLQGFRGDRVELSEGYDNYSCIPCPGGCTNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCCIVLGVIVFRQRKCKAIASGMWTVLETILLGIVLLYASVAVHFFPASTERCLLEPWLRELGFITCYGAIILKLYRHLVDFRTRKAHRWVLRDVDLLKYLGTMVFAVICYMAAFTASSLDLLESAQLESLREADTNTCHPLKWELVTQTSEMLILCFGLHLSIASRNANTQFRERQFLVTALTLEFLVSSSFYFLRFVYLPEMSPSAILLALFIRSQLTNSFALGLIFVPKLWYQHKQVRSLAYDLSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDPDIGELTISEMSPEDIRAELKRLYTQLEIMKNKTLRQDNPHISKRRGGRKAGHRRFSLQVSRGHHNGSVVHHQP
Protein: Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-M3) (Q9WV85)
Organism: Mus musculus (Mouse)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q13232}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13232}. Cytoplasm {ECO:0000250|UniProtKB:Q13232}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30111592}.
Interaction partners:
- Nucleoside diphosphate kinase A
- Nucleoside diphosphate kinase B
- Thymidylate kinase
- Adenylate kinase 9
- Nucleoside diphosphate kinase, mitochondrial
- Nucleoside diphosphate kinase 6
- Bis
- Inosine triphosphate pyrophosphatase
- CTP synthase 1
- UMP-CMP kinase
Sequence:
MICLVLTIFANLFPSAYSGVNERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYVELREKPFYSRLVKYMSSGPVVAMVWQGLDVVHASRALIGATDPGDAMPGTIRGDFCMEVGKNVIHGSDSVESAHREIALWFREAELLCWEDSAGHWLYE
Protein: Thyrotroph embryonic factor (P41224)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
Subcellular location: Nucleus.
Interaction partners:
- Period circadian protein homolog 3
- Nuclear receptor subfamily 1 group D member 2
- Period circadian protein homolog 2
- Nuclear receptor subfamily 1 group D member 1
- Cryptochrome-1
- Basic helix-loop-helix ARNT-like protein 1
- Cryptochrome-2
Sequence:
MSEAGGGKKPPVEPQAGPGPGRAAGERGLSGSFPLVLKKLMENPPRETRLDKEKGKEKLEEDESAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAQNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
Protein: Metabotropic glutamate receptor 6 (mGluR6) (O15303)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Interaction partners:
- Transient receptor potential cation channel subfamily M member 1
- Nyctalopin
- Metabotropic glutamate receptor 4
- Calcium-binding protein 4
- Glutamate receptor ionotropic, kainate 1
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
- Probable G-protein coupled receptor 179
Sequence:
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
Protein: Rifin (Q8I3E4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFALPLNILIYNQRNHNSTTHHTLKIPITRLLCECELYELANYDNDPEMKEVMQQFEDRTTQRFHEYDERMKTTRQKCKDKCDKEIQKIILKDKLEKELMDKFATLHTDIQSDAIPTCICEKSLEDKMEKECLKCAQNLGGIVAPSTGVLGEIAALAVNAWKTEAIAAATKAAIAKGTAKGLAAGAAKGVAEVIAQVESQFRLSTIGVKELGSIFNASNYTNETFISGYIYAQYQGSQCGSLSMLLGKSKPFCTFVEGRIFATSVRVGRSFSPEDFIKTTVQTIVKNAKTTAEATKAQVASAEKAAVLETSKKAIEATTTPYYTPIIVSIVAIVVIILIMVIIYKILRYRRKKKMKKKLQYIKLLKE
Protein: Early growth response protein 2b (EGR-2b) (Protein krx-20) (Zinc finger protein Krox-20) (Q05159)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
Subcellular location: Nucleus.
Interaction partners:
- NGFI-A-binding protein 2
- Early growth response 3.
- E3 SUMO-protein ligase EGR2a isoform 1
- Transcription factor SOX-10
- Paired box protein Pax-2a
- Homeobox protein Hox-B1a
- Transcription factor MafB
- Homeobox protein OTX2
- Myoblast determination protein 1 homolog
- Myelin protein P0 precursor
Sequence:
MTAKTLEKAPVSLGGFVHPLADSIYSVDELGTTLPASVTIYNDLGGHYEQINAGDGLINGDMSTEKRALDLAYSSTFAQPAGPRNQTFTYMGKFSIDSQYPGNWNPEGVINIVSAGILGMTQPSSASSSPASSVSPSHFSSTLSCTMAQNQADMEHIYSPPPPYSGCGEVYQDPSAFLSTSTCPISYPPPSYSSPKPNADSGLFPIIPDYAGFFQPPCQRDMQSMPDRKPFSCPLDSFKLPPPLTPLNTIRNFTLGGPGPDGPRLPTAYTPQNLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHTKIHLRQKERKSSSSSTGVSSSERGVATSICSSSSNQ