Protein: Lysophospholipid acyltransferase 2 (AtLPLAT2) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase 2) (LPCAT2) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lysophosphatidylglycerol acyltransferase) (LPGAT) (Lysophosphatidylserine acyltransferase) (LPSAT) (Q9CAN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Exhibits preference for C18-unsaturated acyl-CoA when transferring an acyl group to lysophosphatidylcholine. Can also utilize lysophosphatidylglycerol (LPG) as substrate in vitro. Has neither activity towards lysophosphatidic acid (LPA) nor lysophosphatidylinositol (LPI). Lysophospholipid acyltransferases catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. The primary function of the Lands cycle is to provide a route for acyl remodeling to modify fatty acid (FA) composition of phospholipids derived from the Kennedy pathway. Is involved in PC acyl editing and phosphocholine headgroup exchange between PC and diacylglycerols. This processes control the majority of acyl fluxes through PC to provide polyunsaturated fatty acids for triacylglycerols synthesis in seeds. Involved with LPCAT1 in the direct incorporation of newly synthesized fatty acids exported form the chloroplast into PC through acyl editing.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:22923678}; Multi-pass membrane protein {ECO:0000305|PubMed:22923678}.
Interaction partners:
- Lysophospholipid acyltransferase LPEAT1
- Lysophospholipid acyltransferase LPEAT2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic
- 1-acyl-sn-glycerol-3-phosphate acyltransferase 2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase 3
- Choline/ethanolaminephosphotransferase 1
- Choline/ethanolaminephosphotransferase 2
- Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4
- Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5
- CDP-diacylglycerol--serine O-phosphatidyltransferase 1
Sequence:
MELLDMNSMAASIGVSVAVLRFLLCFVATIPISFLWRFIPSRLGKHIYSAASGAFLSYLSFGFSSNLHFLVPMTIGYASMAIYRPLSGFITFFLGFAYLIGCHVFYMSGDAWKEGGIDSTGALMVLTLKVISCSINYNDGMLKEEGLREAQKKNRLIQMPSLIEYFGYCLCCGSHFAGPVFEMKDYLEWTEEKGIWAVSEKGKRPSPYGAMIRAVFQAAICMALYLYLVPQFPLTRFTEPVYQEWGFLKRFGYQYMAGFTARWKYYFIWSISEASIIISGLGFSGWTDETQTKAKWDRAKNVDILGVELAKSAVQIPLFWNIQVSTWLRHYVYERIVKPGKKAGFFQLLATQTVSAVWHGLYPGYIIFFVQSALMIDGSKAIYRWQQAIPPKMAMLRNVLVLINFLYTVVVLNYSSVGFMVLSLHETLVAFKSVYYIGTVIPIAVLLLSYLVPVKPVRPKTRKEE