wanglab/gogpt-training-data huggingface dataset:
Protein: Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) (Q86U90)
Organism: Homo sapiens (Human)
Function: Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29760464}. Mitochondrion {ECO:0000269|PubMed:29760464}. Cell membrane {ECO:0000250|UniProtKB:Q3U5F4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U5F4}. Note=A large fraction localizes in the cytoplasm, whereas a smaller fraction is imported to mitochondria. {ECO:0000269|PubMed:29760464}.
Interaction partners:
- tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
- tRNA N6-adenosine threonylcarbamoyltransferase
- Serine hydrolase RBBP9
- EKC/KEOPS complex subunit TPRKB
- Regulatory solute carrier protein family 1 member 1
- EKC/KEOPS complex subunit TP53RK
- EKC/KEOPS complex subunit LAGE3
- Pseudouridine-5'-phosphatase
- Spindlin-1
- Spindlin-2B
Sequence:
MSPARRCRGMRAAVAASVGLSEGPAGSRSGRLFRPPSPAPAAPGARLLRLPGSGAVQAASPERAGWTEALRAAVAELRAGAVVAVPTDTLYGLACAASCSAALRAVYRLKGRSEAKPLAVCLGRVADVYRYCRVRVPEGLLKDLLPGPVTLVMERSEELNKDLNPFTPLVGIRIPDHAFMQDLAQMFEGPLALTSANLSSQASSLNVEEFQDLWPQLSLVIDGGQIGDGQSPECRLGSTVVDLSVPGKFGIIRPGCALESTTAILQQKYGLLPSHASYL
Protein: 34 protein (O41951)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Interaction partners:
Sequence:
MATLSDFFPEADPVLEKNYRRCVDLAINMSWSVPGQFKLVETPINSFLLVGDVLPNDMIESKPVNSTNLVNIPFPLSTLGVSTSKKSVEVTSYKSETEKFQEAASISEHSIRGSIVYEGLTWITAMGYNVTDFLVNMLEQMKCPENWSGLHPVDPLACVWLLYFGPKSRCSEIACVSELFIGKKGPILLPPHMYRGDTSVNSFAHHLCQYVKHLYADYEPEILSCPLDITRVKGCLSDLRQVAESCVFLSQRCLLCHLYKQNAAVSKNILTASDCIILGGSGKSLLGTYMKSYKDPATHDSILLPTYNLEAIVNYILEHYGHETAGQEINWE
Protein: Tubulin alpha chain (EC 3.6.5.-) (Alpha-tubulin) (P32255)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco11
- Tubulin beta chain
- Dynein heavy chain, cytoplasmic
- Cytoplasmic dynein 1 intermediate chain
- Microtubule-associated protein RP/EB family member 1
- Cytoplasmic dynein 1 light intermediate chain 1
Sequence:
MGREIISIHIGQAGVQVGNSCWELYCLEHGIERDGSIPADRKQSSDVNNLNKDLGTFFSESTNGKKVVPRAIFLDLEPTVIDEIRTGDYKNLFHPEQLITGKEDAANNYARGHYTVGKELIDVCVDRIRRLADQCDGLQGFLVFHSVGGGTGSGFGSLLLQKLALDYGGKKSKLDFCVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVSFMLDNEAIYNICKNSLDIEKPTYTNLNRLIAQVISSLTSSLRFPGQLNLDINDIQTNLVPFPRLHFVLCSYAPVISREKAHHETITVDNITSAVFSEKNIMAKCQPNLGKYMACCLMYRGDIVPKEAQKAVQNIRSEKSRNVSFVDWSPTGFKCGINNQAPVSTKDSEMAEVKKSVCMLSNTTAISQVFSRINHKFDLMFVKRAFVHWYVGEGMEEGEFAEARDDLLALEKDYESVSASTEGEEQEEEY
Protein: BURP domain protein RD22 (Dehydration-responsive protein RD22) (Q08298)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts to suppress chlorophyll degradation under moisture stress.
Interaction partners:
- Low-temperature-induced 78 kDa protein
- Low-temperature-induced 65 kDa protein
- Dehydrin COR47
- Dehydration-responsive element-binding protein 2A
- Protein COLD-REGULATED 15A, chloroplastic
- ATMYB2
- Probable peroxygenase 3
- NAC domain-containing protein 72
- 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic
- Delta-1-pyrroline-5-carboxylate synthase A
Sequence:
MAIRLPLICLLGSFMVVAIAADLTPERYWSTALPNTPIPNSLHNLLTFDFTDEKSTNVQVGKGGVNVNTHKGKTGSGTAVNVGKGGVRVDTGKGKPGGGTHVSVGSGKGHGGGVAVHTGKPGKRTDVGVGKGGVTVHTRHKGRPIYVGVKPGANPFVYNYAAKETQLHDDPNAALFFLEKDLVRGKEMNVRFNAEDGYGGKTAFLPRGEAETVPFGSEKFSETLKRFSVEAGSEEAEMMKKTIEECEARKVSGEEKYCATSLESMVDFSVSKLGKYHVRAVSTEVAKKNAPMQKYKIAAAGVKKLSDDKSVVCHKQKYPFAVFYCHKAMMTTVYAVPLEGENGMRAKAVAVCHKNTSAWNPNHLAFKVLKVKPGTVPVCHFLPETHVVWFSY
Protein: Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (Arabidopsis NPK1-related protein kinase 3) (O22042)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Kinesin-like protein KIN-7B
- Kinesin-like protein KIN-7A
- 65-kDa microtubule-associated protein 1
Sequence:
MQDILGSVRRSLVFRSSLAGDDGTSGGGLSGFVGKINSSIRSSRIGLFSKPPPGLPAPRKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFVTGKRQEPYPAYRNSLTECGNPITTQGMNVRSSINSLIRRSTCSGLKDVCELGSLRSSIIYPQKSNNSGFGWRDGDSDDLCQTDMDDLCNIESVRNNVLSQSTDLNKSFNPMCDSTDNWSCKFDESPKVMKSKSNLLSYQASQLQTGVPCDEETSLTFAGGSSVAEDDYKGTELKIKSFLDEKAQDLKRLQTPLLEEFHNAMNPGIPQGALGDTNIYNLPNLPSISKTPKRLPSRRLSAISDAMPSPLKSSKRTLNTSRVMQSGTEPTQVNESTKKGVNNSRCFSEIRRKWEEELYEELERHRENLRHAGAGGKTPLSGHKG
Protein: Zn(2)-C6 fungal-type domain-containing protein (Q2U313)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Essential protein Yae1 N-terminal domain-containing protein
- Translation initiation factor RLI1
Sequence:
MEDHPRPRVHKACDACGRRKVRCNGQQRCQQCEHMGLVCTYTDNRLARSRKHALRRGEVISKHKIESSSNVLLAPALSPVSTSYFESLIPEYMHFVYPFNPIMTEDEVQDAVSKMDSDRENAAFVYAFAAATIDLAQSNRPTSSASTHITQLVNQAIETQPPMFLGFRPSILRTMTNVFIQMCFMSLGQYDLGFIYLREAITMIHLLRIEDKTALANLNPTERARRQRLYWLCFIHERFMSIVHFSPATLSPHASFPEADPTLAPGISQGWTQVIKTFLILEPTFINLWIGDRSQVSAKWVEKKYQELDDARWELEVSMLSETQQADLVITRQWMRTLLWQMAMSNWLLSSRAPCPSLSLELPLRLSGQLRQFLTKISQNTIRVHGSSILTKLVEIINTIADVVIHLPQATLEQTTSRIGDIVFMKSVVFSFHNLQQVSKDILLEKFCLIRDRFPGIEAACQLTF
Protein: Septin-10 (SmSEPT10) (A0A3Q0KDV9)
Organism: Schistosoma mansoni (Blood fluke)
Function: Filament-forming GTP-binding protein. Lacks GTPase activity, which is likely due to absence of an essential threonine residue important for hydrolytic activity in septins. May be involved in membrane remodeling, potentially by its nucleotide-dependent cellular membrane association/dissociation ability. Able to bind to phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes. Self-assembles into ordered cage-like structures on the vesicle membrane. Binds also to 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS)-containing vesicles suggesting the requirement for negatively charged membranes. Is also able to promote deformation of the GUVs.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C1B7}. Note=Colocalizes with actin in the longitudinal and circular muscles of the sporocyst. {ECO:0000269|PubMed:24367716}.
Interaction partners:
- Septin
- Septin-7.2
- Septin
- Putative septin
Sequence:
MTADVLKALPPDVRTLKLSGHVGFDSLPDQLVNKAISQGFVFNILCVGETGIGKSTLLETLFNQKFDFSPSNHDLTDPKLKAVTYDLKEANVKLKLTVVETCGYGDQINKENNIKPVVDYIDNQFENYLQEELKMKRSMQAFHDTRVHVCLYFIAPTGHSLKSIDLVAMKKLENKVNVIPVIAKSDTITKSELQKFKARILSEIQSNEIGIYQFPTDDEAVSETNSVMNQHIPFAVVGSSEEVKINGKTVRVRQYPWGSVQVENENHCDFVRLREMLLRVNMEDLRERTHGVHYETYRRQRLIEMGFRDDEKMSLQETYEKRRELQRKELQQKEEEMRQMFVQRVKEKEQVLKEAERELQTKFESLKKTHAEEKKKLEEKKRFLEEEIAAFERRKQLAEQARQGNLTMKKRK
Protein: Transposase (Q25442)
Organism: Musca domestica (House fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQKMDNLEVKAKINQGLYKITPRHKGTSFIWNVLADIQKEDDTLVEGWVFCRKCEKVLKYTTRQTSNLCRHKCCASLKQSRELKTVSADCKKEAIEKCAQWVVRDCRPFSAVSGSGFIDMIKFFIKVGAEYGEHVNVEELLPSPITLSRKVTSDAKEKKALISREIKSAVEKDGASATIDLWTDNYIKRNFLGVTLHYHENNELRDLILGLKSLDFERSTAENIYKKLKAIFLQFNVEDLSSIKFVTDRGANVVKSLANNIRINCSSHLLSNVLENSFEETPELNVPILACKNIVKYFKKANLQHRLRSSLKSECPTRWNSTYTMLRSILDNWESVIQILSEAGETQRIVHINKSIIQTMVNILDGFERIFKELQTCSSPSLCFVVPSILKVKEICSPDVGDVADIAKLKVNIIKNVRIIWEENLSIWHYTAFFFYPPALHMQQEKVAQIKEFCLSKMEDLELINRMSSFNELSATQLNQSDSNSHNSIDLTSHSKDISTTSFFFPQLTQNNSREPPVCPSDEFEFYRKEIVILSEDFKVMEWWNLNSKKYPKLSKLALSLLSIPASSAASERTFSLAGNIITEKRNRIGQQTVDSLLFLNSFYKNFCKLDI
Protein: Heterogeneous nuclear ribonucleoprotein H1 (D6RBM0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDR
Protein: Small heat shock protein IbpA (16 kDa heat shock protein A) (P0C054)
Organism: Escherichia coli (strain K12)
Function: Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14702418}.
Interaction partners:
- Small heat shock protein IbpB
- Chaperone protein ClpB
- Chaperone protein DnaK
- Protein GrpE
- Chaperone protein HtpG
- ATP-dependent protease subunit HslV
- ATP-dependent protease ATPase subunit HslU
- Chaperone protein DnaJ
- Co-chaperonin GroES
- Chaperonin GroEL
Sequence:
MRNFDLSPLYRSAIGFDRLFNHLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIDLERVIPEAKKPRRIEIN
Protein: TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) (A7MCY6)
Organism: Homo sapiens (Human)
Function: Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
Interaction partners:
- Serine/threonine-protein kinase TBK1
- Tumor necrosis factor
- TRAF family member-associated NF-kappa-B activator
- Calcium-binding and coiled-coil domain-containing protein 2
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon
- 5-azacytidine-induced protein 2
- NF-kappa-B essential modulator
- RB1-inducible coiled-coil protein 1
- TNF receptor-associated factor 3
Sequence:
MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI
Protein: SD05186p (Q960E2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVEDIDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYFHDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIVSIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVAPA
Protein: Pentatricopeptide repeat-containing protein At1g11630, mitochondrial (Q9SAB4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022}.
Interaction partners:
Sequence:
MAFLFRIRTSEFILQKATQFRLKSSSSSIFTLKSLTSKQKKSRDTLSLLKSENNPDRILEICRSTSLSPDYHVDRIIFSVAVVTLAREKHFVAVSQLLDGFIQNQPDPKSESFAVRAIILYGRANMLDRSIQTFRNLEQYEIPRTVKSLNALLFACLMAKDYKEANRVYLEMPKMYGIEPDLETYNRMIRVLCESGSTSSSYSIVAEMERKWIKPTAASFGLMIDGFYKEEKFDEVRKVMRMMDEFGVHVGVATYNIMIQCLCKRKKSAEAKALIDGVMSCRMRPNSVTYSLLIHGFCSEENLDEAMNLFEVMVCNGYKPDSECYFTLIHCLCKGGDFETALILCRESMEKNWVPSFSVMKWLVNGLASRSKVDEAKELIAVVKEKFTRNVDLWNEVEAALPLPQ
Protein: Patj homolog (Q9NB04)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in cell polarity establishment. Probably participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex.
Subcellular location: Membrane {ECO:0000269|PubMed:10102271, ECO:0000269|PubMed:11076972}. Note=Membrane-associated. Localizes to the subapical domain of cells. Sdt is required for its localization. At mitotic cycles 13 and 14, during cellularization, it localizes at the leading edge of the invaginating membranes. It is then exclusively localized to the basal area of columnal epithelial cells. In the germline, it localizes at the membrane of the nurse cells during early and mid oogenesis. Later, it is found in the nuclear membrane in close association with actin filaments that connect the nuclei of the nurse cells with the plasma membrane.
Interaction partners:
- Protein PALS1
- Protein crumbs
- Atypical protein kinase C
- LD29223p
- Protein lin-7 homolog
- Moesin/ezrin/radixin homolog 1
- Exocyst complex component 2
- Zyx102 protein
- Cadherin-86C
- Protein limb expression 1 homolog
Sequence:
MHLSADISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEETLDAQPSPPALPTVAPPAMPPSASMGAEPDLIPDWRN
Protein: Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) (Q15691)
Organism: Homo sapiens (Human)
Function: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. May play a role in cell migration (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10188731, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:9724749}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:14654843}. Golgi apparatus {ECO:0000269|PubMed:25217626}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:27225956}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Note=Associated with the microtubule growing distal tips (PubMed:28814570). In addition to localizing to microtubule plus-ends, also exhibits some localization along the length of the microtubules (PubMed:27225956). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28814570}.
Interaction partners:
- Dynactin subunit 1
- Microtubule-associated protein RP/EB family member 3
- CAP-Gly domain-containing linker protein 1
- Dystonin
- Kinesin-like protein KIF2C
- Cytoskeleton-associated protein 5
- Adenomatous polyposis coli protein
- CLIP-associating protein 2
- Aurora kinase B
- Prelamin-A/C
Sequence:
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY
Protein: Ribosome-recycling factor, chloroplastic (RRF) (CpFrr) (RRFHCP) (Ribosome-releasing factor, chloroplastic) (Q9M1X0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Responsible for the release of ribosomes from messenger RNA at the termination of chloroplastic protein biosynthesis.
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- Polyprotein of EF-Ts, chloroplastic
- Elongation factor Ts, mitochondrial
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS9c
- Large ribosomal subunit protein bL31c
- UMP kinase
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS2c
- Large ribosomal subunit protein uL13c
- Large ribosomal subunit protein bL20c
Sequence:
MAASFSSTAPTTPVLRFRANYSKPLLSLPDSCLRIISSAISPSTRLIACSFKTDKLPLGAGVNLSGGPVVKRSLQKRLVIRSATIEEIEAEKSAIETDVKSKMEKTIETLRTSFNSIRTGRSNAAMLDKIEVEYYGSPVSLKSIAQISTPDGSSLLLQPYDKSSLKAIEKAIVNSDLGVTPNNDGDVIRLSLPPLTSDRRKELSKVVAKQSEEGKVALRNIRRDALKSYDKLEKEKKLSEDNVKDLSSDLQKLIDVYMKKIEELYKQKEKELMKV
Protein: Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) (Q14680)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}.
Interaction partners:
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Disks large-associated protein 5
- G2/mitotic-specific cyclin-B2
- Forkhead box protein M1
- G2/mitotic-specific cyclin-B1
- Cytoplasmic 60S subunit biogenesis factor ZNF622
- Baculoviral IAP repeat-containing protein 5
- Chromosome-associated kinesin KIF4A
- Cell division cycle protein 20 homolog
- Lymphokine-activated killer T-cell-originated protein kinase
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Protein: Glucose-1-phosphate thymidylyltransferase (Glc-1-P thymidylyltransferase) (EC 2.7.7.24) (dTDP-glucose pyrophosphorylase) (dTDP-glucose synthase) (P9WH13)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
Interaction partners:
- dTDP-glucose 4,6-dehydratase
- dTDP-4-dehydrorhamnose 3,5-epimerase
- dTDP-4-dehydrorhamnose reductase
- Possible dTDP-glucose 4,6-dehydratase
- UDP-glucose 6-dehydrogenase
- UTP--glucose-1-phosphate uridylyltransferase
- Probable phosphoglucomutase PgmA
- UDP-galactopyranose mutase
- Uncharacterized protein Rv1510
- N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Sequence:
MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQLITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSVALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKPVTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSGYGNYLLELLERN
Protein: VPS9 domain-containing protein (Q389X4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small GTPase, putative
- Ras-related protein rab-5
- Vacuolar protein sorting-associated protein 29
- Ras-related protein Rab-21
- Polyubiquitin, putative
- Translation initiation factor eIF2B subunit beta
- Vacuolar protein sorting-associated protein 35
- Rab GDP dissociation inhibitor
Sequence:
MNSAASEEQTNVFLMAIRPGGILYPQLQCAPMEVLCCPRQSSLVETGFAPYLSLPAPVENSVVTLSINETTFHLTSTQQEKVSQVLREEFLVYHTLRFASVASSSFVTGRGHKGEFSSDLKSIARFGRIGACAVIGDSITVQLQQREERTLPDGGVNVFILEEPFMDASERQNSIAALKRAVGCSDDGSPQNALGSSGGASPSGPMQGREWRYTREAIESYRRGVSKETDERFAEFQQLMKKPMCFPIVKTLSGFLEAVDKRDSLQIKSSHVTHAITLCMNQCRQIPLLLDDWEKLRIIEEGLEKHIMTKLFKRTFGVCPEEQKCEAELSEKLHRLSKSVRAQDLEALEEVESHNCWEQAMYELDAMNFFKSPRGKFLCSLRAYQQLTEIVRDTVAEIKKARGKNPNKALDADDFGANEFLPCFLLLVLRACPRNFYLNVQYVKNFHSPDRMTPEESYCLATLESAVSFWQSYSNASTGTVTPACAVPAAPAPVSSAPVPVVEPQLQPQANFLDSLFTSPASSIIIPTSGPVDLSSSYNFDDFFNGGGGTVLTPPKKENKINVTKLLLDDKKAFDDLSVAELRAVVEEARSLLAEKRNARS
Protein: Globin domain-containing protein (B3WFV1)
Organism: Caenorhabditis elegans
Interaction partners:
- Globin-like protein 26
- Globin domain-containing protein
- Globin domain-containing protein
- Globin domain-containing protein
- GLoBin related
- GLOBIN domain-containing protein
- Globin domain-containing protein
- GLOBIN domain-containing protein
- Globin-like protein
- GLOBIN domain-containing protein
Sequence:
MPSAARQLVSNMLSFLSSPSPQTSVSEKGASFSTPQANRKNKVNGNRRMSDSNNVAYSNGSKKVFEGDIEKWEPNVYEKELLRRTWSDEFDNLYELGSAIYCYIFDHNPNCKQLFPFISKYQGDEWKESKEFRSQALKFVQTLAQVVKNIYHMERTESFLYMVGQKHVKFADRGFKHEYWDIFQDAMEFALEHRLSIMTDLDDNQKRDAVTVWRTLALYTTVHMRNGFIDGLKGVNRFPPLV