wanglab/gogpt-training-data huggingface dataset:
Protein: rRNA biogenesis protein rrp5 (Ribosomal RNA-processing protein 5) (U3 small nucleolar RNA-associated protein rrp5) (U3 snoRNA-associated protein rrp5) (O74835)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein mpp10
- Ribosome biogenesis protein bms1
- U3 small nucleolar RNA-associated protein 4
- Probable U3 small nucleolar RNA-associated protein 7
- Periodic tryptophan protein 2 homolog
- Probable nucleolar complex protein 14
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 22
- Nucleolar protein 58
- Uncharacterized protein C1604.06c
Sequence:
MAGNKRKRSNASEGSDSQGNERISSLSANEATQDFPRGGASSLTPLEYKEAVLEAKKDFMESASGTAELSKKTRPKKKGSKKSSKSELDNEENLKVHIQSLRYKNITPGSLILGQIAQINTLDLAVSLPNCLTGYVPITNISDKLSDRLDSIDNHAEDNAATEEEDGLNQIPDLMDLYKVGQWVRVSVTALGSENTTKTGKRHIELSLKPQDANGSAPEAADFVAGSMIQAVVSSIEDHGIVFDIGINNYTGFLSKKHINDFPFVEGQSLLCSVISKEDRIFHLSLTATSTKALEVMPSVQAILPGDYINVLVTDIKESGVIAKYMGVVDVTSDIYHSSPVKGEDLEDKFQLAKSVPARVLFVIPGDPPKIAVSFLPHVLTFNFATPNTPHPDQLDIGFIVNAAKVTYVSSSLGVFCDVGVPEISGFAHISRLSDKKVAGISPNSGPYKVDSTHEARIINYSYVDNLYILSFQQSVLNQQFLRIEDIEVGQFVDGTIAKLIPQGIVVTISEGINGLVPSTHMADIALQFPERRFKVGSSVKCRVLSTNVLRKRVLLTLKKSLLNTDLPLIYDYEQATPGTQTVGTLARIFEDGAIVEFYNSVRAFLPVSEMSEAYIRDAREHFKVGQTLSVTIVSCDPENRKMRVGCREQSWDAKRLERFENIKAGSVLSGIVLQKTEDSVIVDLGDKVTGVITLGQLCDGDLNKCSKVMNKLRASTKLAEVLVLRKDTSKKLISLSLKKSLVEAAKENRMPINITDLKEGIKYFGFVRNATTFGVFVEFCDGLVALVPKAYISEEYVPVPSAVYKPQQSVTCVCLSVELSQEKAFMSFKPLAQKQEKAVEFMESKYDIDNPVDETIKKTYDYVAGKITWAVVTSAKASQLNVDLAANVHGRVDVSEVFDNFGEIVDPNKPLKRFHKGDKIRVRVLGIHDSRNHKFLPISHRVSPKQFLELSVRPSILNMEPFSMKEPQFKKGDEVTGFVNNVSKECVWVSLTPSVNGRIPILDLTTDVKELNSLQKHFFLGKAIKCYVVNAEDSITLSAIGPLQGFENLTPGSRLVGKVTNVNEAGAILQLPGHMSGRVSRIDMFDDYDILPETKFTRNNLVGVCVLSVDVPNRKVALSARNSRTQSQPVEIKDKEINSVDDLKIGDICRGFVCNVANQGLFVTIGHNLIARVKIGELFDTFIKDWKPHFHVNQLVKGSIVGIDNDSKRIEMSLKQSKIKDSSEITKTFADIAVGSNLDGTVVKVGDYGVLIRIDGTDNIVGLCHKSEIADAVVLNISKLYSSGDKVRAHVLDVDSEKRRIALGLKSSYFDSDSDISMSDNEEDVEMRSEDQSDTSESEVGSKDDVQSEEVENLESAGDEDEEEEPSALQANGFDWTDGSTVFDKLADDTEDSEDEEDEEPKRKKSKSDRFDDEEKDLDEIPSTAADFERQLLSSPNSSLLWISYMAYHLNLNELQEAREVGKRALSTINYREEDEKLNVWMALLNLEVAYGTEDSLKEVFKEACAYCDALIVYEKLCGILIKGGKVDLADEYMQLMLKNFKQVPSVWIQYATFLLNNDKAEKAHGLLERSLQSLPKSEHVGIIEKFAILEFKNGDPERGRTIFEGLLSSYPKRLDLWNVLIDMEMKQDDPSIVRRLFQRLLALNLSTKKAKFAFKKWLAYEKNIGDDEGAEQVKRRAIEYVSESHSEN
Protein: Methyl-accepting chemotaxis protein III (MCP-III) (Ribose and galactose chemoreceptor protein) (P05704)
Organism: Escherichia coli (strain K12)
Function: Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles.
Interaction partners:
- Chemotaxis protein CheA
- Chemotaxis protein CheW
- Protein-glutamate methylesterase/protein-glutamine glutaminase
- Chemotaxis protein methyltransferase
- Chemotaxis protein CheY
- D-galactose/methyl-galactoside binding periplasmic protein MglB
- Ribose import binding protein RbsB
- Transcription-repair-coupling factor
- ATP-dependent DNA helicase RecG
- Protein phosphatase CheZ
Sequence:
MNTTPSQRLGFLHHIRLVPLFACILGGILVLFALSSALAGYFLWQADRDQRDVTAEIEIRTGLANSSDFLRSARINMIQAGAASRIAEMEAMKRNIAQAESEIKQSQQGYRAYQNRPVKTPADEALDTELNQRFQAYITGMQPMLKYAKNGMFEAIINHESEQIRPLDNAYTDILNKAVKIRSTRANQLAELAHQRTRLGGMFMIGAFVLALVMTLITFMVLRRIVIRPLQHAAQRIEKIASGDLTMNDEPAGRNEIGRLSRHLQQMQHSLGMTVGTVRQGAEEIYRGTSEISAGNADLSSRTEEQAAAIEQTAASMEQLTATVKQNADNAHHASKLAQEASIKASDGGQTVSGVVKTMGAISTSSKKISEITAVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRTLASRSAQAAKEIEGLISESVRLIDLGSDEVATAGKTMSTIVDAVASVTHIMQEIAAASDEQSRGITQVSQAISEMDKVTQQNASLVEEASAAAVSLEEQAARLTEAVDVFRLHKHSVSAEPRGAGEPVSFATV
Protein: MYB-like transcription factor ETC1 (Protein ENHANCER OF TRY AND CPC 1) (Q9LNI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MYB-type transcription factor involved in epidermal cell fate specification. Acts as a negative regulator of trichome development, by mediating lateral inhibition. Promotes the formation of hair developing cells in H position in root epidermis, probably by inhibiting non-hair cell formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:15584952}.
Interaction partners:
- Transcription factor GLABRA 3
- Transcription factor EGL1
- Homeobox-leucine zipper protein GLABRA 2
- Protein TRANSPARENT TESTA GLABRA 1
- Transcription factor MYC1
- Transcription factor RHD6
- Protein TORMOZ EMBRYO DEFECTIVE
- Zinc finger protein GIS2
- WRKY transcription factor 44
- Uncharacterized protein At2g30430
Sequence:
MNTQRKSKHLKTNPTIVASSSEEVSSLEWEEIAMAQEEEDLICRMYKLVGERWDLIAGRIPGRTAEEIERFWVMKNHRRSQLR
Protein: Pleckstrin homology domain containing A7 (A0A8I6A1V7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAAVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASFFIDHNQQTTTFRHPVTGQFSSENSEYVLREEPHPHMSKQERNQRPSSMVSETSTAGTTSTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQAEHSGMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLKRDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDAIVFDRREQEEERFRSQRDTLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAERNGLPPYGLGEQNGTSGYSRTAPPRANLEKHSQRKTNLAQTEHWAKAQKGDGRSLPLDQTLPRQGPSQPPSFLENYQTLPRNTRYPSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKPPDQRRSVDISLGGSPRKARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPMKIAESDTDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSVNKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVVSPLQSPTKATPQAEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASFSGDVPRPSLGLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSVTFSRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLLSARYLSQPLPGDLGSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELDLEPQDYDLDINRELSKPEKVSIPERYVEVDPEEPPSVEELQARYQKAEKIRNILARSSMCNLQPPGQDRNSLADLDTQMQEQERIINISYALASEASQRSKQVAGKAVGASLQGPVPACCS
Protein: Uncharacterized MFS-type transporter Rv1250 (P9WG87)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAWGTVASVASLVGPLAGGALVDSMGWEWIFFVNVPVGVIGLILAAYLIPALPHHPHRFDWFGVGLSGAGMFLIVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSLSNLRIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLGFGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGASSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREPFAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRREPEEDCDTQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTESTAPSAL
Protein: Uncharacterized protein (Q383Q3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCDEFFGDLLEEELENLGKAAFVVGVSGFLLKQAIGARSFLRGDPVQNSIVAHLPQGYDRSIIAARVSQPLTKSLMIDALAIGAIKERLRRATTPGDKVAIFSELFNTTLAGILSAAYIHSLTITLHVMRHTMSLLVFVLGKQEASSGTRRANTSLLSKFRSWWHQGTQNFMLQTLLENMTQQMEASPFSLMMDDDNMKTEDVKQGFCVDALLRLAVPRVVDTALHVVNTTLEGRDSQLFNLTGSVTEGEMRDLLQTLCAKFVSRATLSDWLTPPSEELKDSDGGVLNTSPPPQGMGDGESGGESPGGRDKAMSNGDSLMSNDEQSEDRLGLGGGGGGGMPLQGVFPPLSANFFPMANGAAHAEEMHTAHRNRLIHEKLRRERAAGFFREIVHSVSLSELCIAYTEELLGAAVAVTTDFSSLRPEGDSTVAVRVPQMLPLLEKQRLDMFDCDFQVQPYVRLLCEETIRVTCRDL
Protein: Uncharacterized protein DKFZp586G1518 (Q8NDP0)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
PLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT
Protein: Zinc finger protein 395 (A0A286YDB9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLSRRLGKRSLLGARVLGPSAAEVPSGATLPLEPQIEVPEGAMSLSPLTSKDPVCQEQPKELLKALGTSGHPQVAFQPGQKVCVWYGGQECKGLVEQHSWA
Protein: Cellular tumor antigen p53 (E7EQX7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}. Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}. Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSRPRQVDHLRSGVQDSLANIAKSHLY
Protein: Probable phospholipase C1020.13c (EC 3.1.1.-) (Q7LKZ6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable phospholipase that hydrolyzes phosphatidic acid.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MQESSQEEPVHYVQWFYLSNYDLYDETSSMELTGAQSWRRFLNYDNNALEAKYNEIITEEVSQEPNQKNVIVGISGLHVVNLPTLTLKPLYWPSASKNDTLRVVRGLWMYEDTGLPVINELSDMLEEGYQEVKPYAVNWDNVLKEEEEGKDSQDDPSVLSHKRNKSSKELIDAMQWPLKPTSSGKYVFYEDGYRALICQGGLLSYFSKGTQSRRTSIKGMPVVRDFPYFEDDGFNGPKQVTDLFLVVHGIGQKRSETEERFLFTKTCNVFRSLIQIQKNIMKEDPLIRNDYEPQLLPICWRNKLNFNSYIKPVAGDEGRVEDEEFEENRFSIEDIEIDSIPAVRRLLGDVMSDIPYYMSHHKESIIKSVIREANRVYHLWKDCNPYFLENKGRIFIIGHSLGSTVVFDILSLQPTFVKEITIDDDESCFIFDTNGFFCFGGPVGFFLHLNQQSIIPRRGRGSSRYEINKNFINSDVPKSYTYDGYDRYGCLAVDSFYNIYNHLDPVAMRLNPTVDLSFSKGIHPTRILFTRKSSSILRMISHSNTDPVELRSYNQSLQQNKNNEPTAVVPLEPEQTVELETRNFRREERAKWRMQELNENSQLDYVFTSAHGVISNKYLSMLSAHSSYWSSEDLACFLVVETGRNFGIANSIEQFRGKHMPRIFKGDSS
Protein: RNA chaperone ProQ (P45577)
Organism: Escherichia coli (strain K12)
Function: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00749, ECO:0000269|PubMed:10049386, ECO:0000269|PubMed:15476391}.
Interaction partners:
- Tail-specific protease
- Free methionine-R-sulfoxide reductase
- Lipoprotein NlpI
- Proline/betaine transporter
- Negative modulator of initiation of replication
- UPF0352 protein YejL
- Uncharacterized protein YjaG
- Regulator of ribonuclease activity B
- Outer membrane protein assembly factor BamC
- UPF0208 membrane protein YfbV
Sequence:
MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAATAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTVKAPREEQHTPVSDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
Protein: Ribosomal RNA-processing protein 1 homolog (Q9Y7M6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for 27S rRNA processing to 25S and 5.8S.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein mak16
- Ribosome biogenesis protein brx1
- Brix domain-containing protein C4F8.04
- Ribosome biogenesis protein erb1
- Ribosome biogenesis protein nsa1
- Probable rRNA-processing protein ebp2
- Ribosome assembly factor mrt4
- Uncharacterized RNA-binding protein C1827.05c
- Ribosome biogenesis protein rlp24
- Pescadillo homolog
Sequence:
MSAPSPFIKKLAANDRKTRDKALESLQRFLSQKKKFERLDFLKLWKGLFYCMWMADKPLYQQKLSDNLAALVPIVWIDNRILFQSTFWETMGREWTGIDILRTDKFYLLMRRFCAAAFRDIQTRSKTALLDKVVAEYNQMWMDGPFNTENLAFPNGILFHLADIWTEELRKVYPEDVPKADWYLPFDSTIKSSHNVVLRKTLPKRLDRVSEYTKDSQ
Protein: Hig-anchoring scaffold protein, isoform G (Hig-anchoring scaffold protein, isoform H) (B7YZX0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Locomotion-related protein Hikaru genki
Sequence:
MNRLLLQCLVTTILVYKVISVPTSTMSTSIQTTSEIPQQDDDDDDWEEDDDSLESDDDGRVYKNPRNSPSTECPRDEEQATLLGQKCLRKCSSDEDCKSKKKKCLCDGVCGNSCIKPDRECPELAQPSLGQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKNGKATYTTLAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYEFPVSLLSPPTCNNGTWSIIPRCVPARCKSMPRPPKHGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDLPQCLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKGENATARCIRGIWKPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRCAHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCHKGILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVYKNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENGTCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKPVCSGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIPMRRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQGSAPYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQACSYPGTVISGRMSSVKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCVTNEGPVGGGGGGGGGGGGGSGSVATNKHLATTMG
Protein: Major facilitator superfamily domain-containing protein 12 (Protein grizzled) (Q3U481)
Organism: Mus musculus (Mouse)
Function: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells (By similarity).
Subcellular location: Melanosome membrane {ECO:0000250|UniProtKB:Q6NUT3}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NUT3}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- UNC93-like protein MFSD11
- Major facilitator superfamily domain-containing protein 6
- Major facilitator superfamily domain-containing protein 9
Sequence:
MSPPSDDAGPGPPRTLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCVRCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSAHGEQDISVGDQLGVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPLVAPAAQPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMAVQSLHPCPSELCCGACISFYHWVMTAVTGGVGVAAALALCSLLIWPIRIRNRDPRDRP
Protein: Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31) (Q3SWT0)
Organism: Rattus norvegicus (Rat)
Function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P16284}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16284}. Membrane raft {ECO:0000250|UniProtKB:P16284}. Cell junction {ECO:0000250|UniProtKB:P16284}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000250|UniProtKB:P16284}.
Interaction partners:
Sequence:
MLLALLLTMLLYASLQAQENSFTINSIHMESRPSWEVSNGQKLTLQCLVDISTTSKSRPQHQVLFYKDDALVYNVSSSEHTESFVIPQSRVFHAGKYKCTVILNSKEKTTIEYQLTVNGVPMPEVTVDKKEVTEGGIVTVNCSMQEEKPPIYFKIEKVELGTKNVKLSREKTSNMNFVLIEFPIEEQDHLLVFRCQAGVLSGIKMQTSEFIRSEYVTVQEFFSTPKFQIQPPEMIIEGNQLHIKCSVQVAHLAQEFPEIIIQKDKAIVATSKQSKEAVYSVMALVEHSGHYTCKVESNRISKASSILVNITELFPRPKLELSSSRLDQGEMLDLSCSVSGAPVANFTIQKEETVLSQYQNFSKIAEERDSGLYSCTAGIGKVVKRSNLVPVQVCEMLSKPRIFHDAKFEIIKGQIIGISCQSVNGTAPITYRLLRAKSNFQTVQKNSNDPVTFTDKPTRDMEYQCIVDNCHSHPEVRSEILRVKVIAPVDEVTISILSGNDVQSGDEMVLRCSVKEGTGPVTFQFYKEKEGRPFHEETVNDTQVFWHHEQTSKEQEGQYYCTAFNRASIVTSLRSGPLTVRVFLAPWKKGLIAVVVIGVVIAALIVAAKYYFLRKAKAKQKPVEMSRPAVPLLNSNSEKVSEPSVETNSHYDSQNMDVEYTEVEVSSLEPHQENGRLP
Protein: Transmembrane protease serine 2 (C9JKZ3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR
Protein: Fucolectin-5 (Q9I927)
Organism: Anguilla japonica (Japanese eel)
Function: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Subcellular location: Secreted {ECO:0000269|PubMed:10924498}.
Interaction partners:
Sequence:
MKTCNLTDRMKVKMIMLLFQILAISTLQSDSAYIPDRYTQENVAVRGKATQSALASGGGAVLSLPGYAIDGNRDSDSSHGSCSHTTNGPNPWWRVDLLQVYTIASVTITNRGDCCGERITGAHILIGNSLENNGINNPQCSTVGIMTAGETRTFHCSRPMIGRYVTVYLPKTEYLQLCEVEVNALLPAN
Protein: DNA replication and repair protein RecF (P05651)
Organism: Bacillus subtilis (strain 168)
Function: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. Is recruited to repair centers, foci that are the site of double-strand DNA break(s) after RecN and RecO; recruitment may depend on RecO.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:15186413}. Note=Cytoplasmically located in untreated cells. Recruited to foci following treatment with DNA damaging agents; these foci are presumably the breaks themselves. They are almost always located within nucleoids (PubMed:15186413). {ECO:0000269|PubMed:15186413}.
Interaction partners:
- Beta sliding clamp
- DNA repair protein RecO
- Recombination protein RecR
- Chromosomal replication initiator protein DnaA
- DNA gyrase subunit B
- ATP-dependent DNA helicase RecG
- Single-stranded-DNA-specific exonuclease RecJ
- DNA repair protein RecN
- Protein RecA
- Holliday junction resolvase RecU
Sequence:
MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIYVLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQKLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQRNHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGLEELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNGRDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTIQGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK
Protein: Uncharacterized protein (Q9FLB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGKSMVRFAEFAIRLSSENPTRPHRPSPSPRNKVFVKKTTRDTTSHLDYSNLVKLEKAGSHSGSNPAPASGSDPINRVPLAQVVEDCVRRWFQDTLKEAKSGDVGMQVLVGQMYCSGYGIPKDENKGRAWINKASRTRSSAWQGIMQAIQIPMIRKIDDHLLNVCIAIDFDLLVSLSFV
Protein: Transmembrane channel-like protein 1 (D3KZG3)
Organism: Caenorhabditis elegans
Function: Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23364694}; Multi-pass membrane protein {ECO:0000269|PubMed:23364694, ECO:0000269|PubMed:36224384}.
Interaction partners:
- EF-hand domain-containing protein
- Transmembrane inner ear
- Arrestin C-terminal-like domain-containing protein
- Ion transport domain-containing protein
- Degenerin mec-10
Sequence:
MQEAARRASLRKEHTPTNEKFGDLSKQDSLGERASSKLTLDDELYDILYAFGETDAFINKGDKQRETDEDGNPLTRQALLERIRQKKEVIGKLRCQAWSMTRKRRTLKLAQKYLEQHESKVSRSHLYMEEMRKRARLMKRSFSNFKTYLIPWESKIKRIESHFGSVVSSYFTFLRWIVFVNIMITLIALVFVVLPETLADSVANEGRFNRTKTRKQIPANERVHADELAVVWHYDGYLRYSPLFYGYYSDDPFLGNKIKYALPLAYFMVTLTIFAYSFFAILRKMAANARMSKLSGSKAEQYIFNWKLFTGWDYTIGNSETASNTVMAVVIKLRESIADIKKDAHGKFRLLQFSLRVFANIIICAMLGFSIYCIIFAVQKSQVQDDGNLFTKNQVPSVVSTITHVFPMIFDLIGKMENYHPRTALRAHLGRVLILYTVNYITLIFALFEKMTALRDRVNSTSTSSSHRTKRQQGGWNPNMQRPPPYASRAEVRQMSDFLAANTRRFQTVSQRTTRSVTTPFTVAPQFGPFNVNNPNAVFHNGTHSTSFESQILGPKALPIFTPPPRKYPGFTPGNVGQQFGGPDFPRNQVYTKSTPLPRVRTKPPWVYTTTHPPLVQNRAMTTTMSKSAKKGNSKNLDDDILLSNETIQMSEAALRRNHDGHNNDICWETIIGQEIVKLVTMDLIFTILSILVIDLFRGLWIKYCSSWWCWDIETTFPEYGEFKVAENVLHIINNQGMIWLGLFFAPLLPAINNIKLIILMYIRGWAVMTCNVPAREIFRASRSSNFYLGILLIWLLLCTLPVGFVIASMSPSRSCGPFARYQHFYTVVTREIEKRVDQTVLSYIRHIASPGVVIPIILFLILIIYFLFSLVRGLREANTDLQAQLVHERTEEKKKIFELAGGKKNKFEKDRDKKRSNDYIPLIEQRRREPWRQYHEMEADHALASDSSEESDINEDEDDERQPLTAYPLRAIETPPETLQVTAFHPSLGSLIENREMEDEESASGDQLPMIHKSVSFQGPSHMQMRQSISTESCSQISRSAIQVATPEEIRALLRPYLEAKYGIPYQHGIKSFPIDVHTPPNNTPSRRSSKYNSFVSLYEHTRDDHKNFVASTIKETDEDPGKSDKKQTSSKDVAPDFMPWPSADEARALREKMKSKTPLMLTKTTVEEKPKGGKSSESEFRPPVPIHRKYNIQTTEEENEEEETDSAPESSKKRFRISVSPTKTIAPASASRAQHKIVSQASSSSSIPHGRQPDPNKKASLVLPPLRAPRVQFDEDDSPRQID
Protein: Proteasome alpha 7 subunit (EC 3.4.25.1) (D6XCY8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome subunit beta
- Proteasome regulatory ATPase subunit 1
- Proteasome subunit alpha type
- Proteasome subunit alpha type
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome regulatory non-ATP-ase subunit 2
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory non-ATP-ase subunit
Sequence:
MSGSGHDQSTDIFSADGRVFQVEYACKAVDNGSTAVAACCKDGVVVAVEKILTSRMLEEGSNNRIHAVDRQAGICVCGVLPDGLAVVSRARGEAENSRDIFSTPILGSLLASRIGEFMHVYTTHYAYRPFGCSVIIASYADDGPQLYVADPSGAVAGYYGIALGKGKTVAKTELEKLDFATLTCSEAVEKLTNILHEVHDKSKDKIYEVEVAWVCDKSDRTFVHVPKEMVPHPTPAS