wanglab/gogpt-training-data huggingface dataset:
Protein: L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (P16125)
Organism: Mus musculus (Mouse)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07195}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- L-lactate dehydrogenase A chain
- Pyruvate kinase PKM
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Pyruvate kinase PKLR
- Pyruvate carboxylase, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Probable D-lactate dehydrogenase, mitochondrial
Sequence:
MATLKEKLIASVADDEAAVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDL
Protein: Prion protein 1 (Prion protein b precursor) (Q3BDW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGELCKLLAIVLVLMAVLHYTSGGKKGTVSKTVPKKPPEKTSQGTKTQPNYPRQPSNPGAGSNPGYPNQQYPGRGGSSPSGYPNQNPGAGSYPAGGSYPYPGRGGSSPGGYPNQNPGAGSYPSGGSYPSAGGNPNQYPGRGGYNPGGYPNQNPGAGSYPAGGSYPSAGGNPNQYPGRGGTSPAGYPNQNPGAGSYPAGGSYPSAGGNPNQYPGRGGSNPGGYPNQNPGAGSYPAGGSYPSAGGNPNQYPGRGGSSPGGNPNQNPGAGTYAGGGYPNQYPGGGGYSNQNPGRSGYSPGGYPGAGSYPVRNAGQPGVYPGAHPSAGGGYPNWNPNNQILSPRYGGPFGGGGFGTGGSPFSQSVKNMGYNPSAKSKGFGKKAVVAAGVGAMAGMAIGYGIGNFQRPNFQFRSPQEERYYNNHMYQRQDTRFKDGGNKKKPSHTAGTDNTSKLPAQAQSYDNFMKTCMKRNNLLRDQDSKESAGNSNIQRDEPMSDFPGLNEESSQKGGPEKNDTTSNTTTRDYPKAADIHKNEDEETVSIMQIGYPALIEQMKSRKCVELYIVYSESQRDDRMEKREGKIPRSSNNHNGHSISEVLLLLTASTMLFSTT
Protein: Protein PEROXIN-4 (AtPEX4) (E2 ubiquitin-conjugating enzyme 21) (Probable ubiquitin-conjugating enzyme E2 21) (EC 2.3.2.23) (Ubiquitin carrier protein 21) (Q8LGF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for peroxisome biogenesis. Necessary for the developmental elimination of obsolete peroxisome matrix proteins. May be involved in the ubiquitination of PEX5, targeting it for recycling. Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:P29340}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Peroxisome biogenesis protein 22
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
- Polyubiquitin 14
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Peroxisome biogenesis factor 10
- Polyubiquitin 10
- Vacuolar fusion protein MON1 homolog
- Ubiquitin-activating enzyme E1 2
- Peroxisome biogenesis protein 5
Sequence:
MQASRARLFKEYKEVQREKVADPDIQLICDDTNIFKWTALIKGPSETPYEGGVFQLAFSVPEPYPLQPPQVRFLTKIFHPNVHFKTGEICLDILKNAWSPAWTLQSVCRAIIALMAHPEPDSPLNCDSGNLLRSGDVRGFNSMAQMYTRLAAMPKKG
Protein: Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) (Q8R003)
Organism: Mus musculus (Mouse)
Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mostly nuclear. {ECO:0000250}.
Interaction partners:
- KH domain-containing RNA-binding protein QKI
- CUGBP Elav-like family member 1
- Myotonin-protein kinase
- CCHC-type zinc finger nucleic acid binding protein
- Chloride channel protein 1
- CUGBP Elav-like family member 2
Sequence:
MTPVNVALIRDTKWLTLEVCREFQRGTCSRADAECRFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKSQLEVNGRNNLIQQKTAAAMFAQHMQLMLQNAQMSSLASFPMNPSLAANPAMAFNPYMTHPGMGLVPAELLPNGPVLISGNPPLALPGVPGPKPIRTDRLEVCREFQRGNCTRGESECRYAHPTDVSMIEVTDNSVTICMDYIKGRCSREKCKYFHPPPHLQAKLRAAHHQMNHSAANAMALPHGALQLIPKRSALDKANGATPVFNPSVFHCQQALANMQIPQQAFIPTVPMMHGATPSTVSTATPPASNVPYVPTTTGNQLKY
Protein: Putative glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Q10179)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable cysteine--tRNA ligase
- Valine--tRNA ligase, mitochondrial
- Valine--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- Putative leucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Histidine--tRNA ligase, mitochondrial
- Putative leucine--tRNA ligase, mitochondrial
- Putative proline--tRNA ligase C19C7.06
- Tyrosine--tRNA ligase, cytoplasmic
Sequence:
MTEVSKAAAFDRTQFEELMKKRFFFSPSFQIYGGISGLYDYGPPGSALQSNLVDIWRKHFVIEESMLEVDCSMLTPHEVLKTSGHVDKFADWMCKDPATGEIFRADHLVEEVLEARLKGDKEARGQNSNDQPEESDDKKKRKKKVKEIRATRLDDKTVEEYEFILAQIDNYDGDQLGELMKKYDIRNPATNGELETPRQFNLMFETQIGPSGGLKGYLRPETAQGQFLNFSRLLEFNNGKVPFASAMVGKAFRNEISPRSGLLRVREFLMAEVEHFVDPKNKEHDRFDEVSHMPLRLLPRGVQLEGKTDILEMPIGDAVKKGIVDNTTLGYFMARISLFLEKIGIDMNRVRFRQHMSNEMAHYACDCWDAEIQCSYGWIECVGCADRSAYDLSVHSKATKTPLVVQEALPEPVVVEQFEVEVNRKKFGPRFKRDAKAVEEAMISWPESEKVEKSAQLVAEGKIIVNVNGVEHTVESDLVTIEKRKHTEHIRTYTPNVIEPSFGLGRILYVLMEHAYWTRPEDVNRGVLSFPASIAPIKALIVPLSRNAEFAPFVKKLSAKLRNLGISNKIDDSNANIGRRYARNDELGTPFGLTVDFETLQNETITLRERDSTKQVRGSQDEVIAALVSMVEGKSSFEDALAKFGEFKSTQE
Protein: Zinc finger protein 747 (Q9BV97)
Organism: Homo sapiens (Human)
Interaction partners:
- Suppressor of fused homolog
- Transcription intermediary factor 1-beta
Sequence:
MTDPSLGLTVPMAPPLAPLPPRDPNGAGSEWRKPGAVSFADVAVYFSREEWGCLRPAQRALYRDVMRETYGHLGALGVGGSKPALISWVEEKAELWDPAAQDPEVAKCPTEADPDSRNKEEERQREGTGALEKPDPVAAGSPGLKAPQAPFAGLEQLSKARRRSRPRFFAHPPVPRADQRHGCYVCGKSFAWRSTLVEHIYSHRGEKPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFMRRTALTSHLRVHTGEKPYRCPQCGRCFGLKTGMAKHQWVHRPGGEGRRGRRPGGLSVTLTPVRGDLDPPVGFQLYPEIFQECG
Protein: GRAP2 protein (GRB2-related adaptor protein 2, isoform CRA_a) (cDNA, FLJ93267, Homo sapiens GRB2-related adaptor protein 2 (GRAP2), mRNA) (Q6FI14)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
Protein: Olfactory receptor (A0A0M3VGY0)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
DPLHYPIIMSRRSCAQLAAASWFSGFPVATVQTTWIFSFPFCGPNMVNHFFCDSPPVIALVCADTSLFELEALTATVLFILFPFLLILGSYVRILSTIFRMPSAEGKRKAFS
Protein: Cytochrome b-c1 complex subunit 2, mitochondrial (Core protein II) (C8V3P5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Complex III subunit 9
- Uncharacterized protein
- mitochondrial processing peptidase
- quinol--cytochrome-c reductase
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b
- Cytochrome c oxidase subunit
- Cytochrome c oxidase subunit 4, mitochondrial
Sequence:
MMLSRSAISRNAPRALQNAASRRGMASAATPGLQYDVSEAAGVKIANREPAGVTGTLALVAKAGTRYQPFPAFSDALELFAFQSTLKRSALRITREVELLGGEFSSTHSRENVVLKTKFLANDLPYFVELLAEVASQTKYPSYELNEIIAKLLKLRQVAIANDPEAVAVDAVHGVAFHQGLGETITPSAHAPYEKNLSAEAIAEFAKNAYAKSNIALVGSGVSSAELSKWVGDFFKGLPNAGTTGRYQVKSDSASKYYGGEQRISTKAGNSVVIAFPGTSAFGTSSYKPAASVLAALLGGESSIKWSPGFSLLGQATQGFSQLRVSTKNHAYSDAGLLTVTLSGKADQVASAGKTVVDALKKAAAGEVPADDIKKATAFAKFQALESAQTLATGLEATGSALINGSKPYQIGEVAQSVDSVTEAQVKDLAKSLLSGKASVASVGDLSQLPYAADLGLTV
Protein: 40S ribosomal protein S15 (F14M2.2 protein) (Ribosomal protein S19 family protein) (Q9LD48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein uS12z
Sequence:
MEPEVVAAGIVKKRIFKKFSFRGVDLDALLDMSTEDLVKHFSSRIRRRFSRGFTRKPMALIKKLRKAVKS
Protein: Type IV pilus assembly ATPase PilB (P22608)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm. PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15659660}. Note=Displays polar localization. {ECO:0000269|PubMed:15659660}.
Interaction partners:
- Prepilin leader peptidase/N-methyltransferase
- Type IV major pilin protein PilA
- Type IV pilus inner membrane component PilM
- Fimbrial assembly protein PilQ
- Type IV pilus inner membrane component PilN
- Type IV pilus inner membrane component PilO
- Type IV pilus inner membrane component PilP
- Type II secretion system protein F
- Probable type II secretion system protein
- Probable type II secretion system protein
Sequence:
MNDSIQLSGLSRQLVQANLLDEKTAVQAQAQAQRNKLSLVTHLVQSKLVSGLALAELSAEQFGIAYCDLNSLDKESFPRDAISEKLVRQHRVIPLWRRGNKLFVGISDPANHQAINDVQFSTGLTTEAILVEDDKLGLAIDKLFESATDGLAGLDDVDLEGLDIGSADKSTQEDASAEADDAPVVRFVNKMLLDAIKGGSSDLHFEPYEKIYRVRFRTDGMLHEVAKPPIQLASRISARLKVMAGLDISERRKPQDGRIKMRVSKTKSIDFRVNTLPTLWGEKIVMRILDSSSAQMGIDALGYEEDQKELYLAALKQPQGMILVTGPTGSGKTVSLYTGLNILNTTDINISTAEDPVEINLEGINQVNVNPRQGMDFSQALRAFLRQDPDVIMVGEIRDLETAEIAIKAAQTGHMVMSTLHTNSAAETLTRLLNMGVPAFNLATSVNLIIAQRLARKLCSHCKKEHEVPRETLLHEGFPEDKIGTFKLYSPVGCDHCKNGYKGRVGIYEVVKNTPALQRIIMEEGNSIEIAEQARKEGFNDLRTSGLLKAMQGITSLEEVNRVTKD
Protein: MICOS complex subunit MIC60-1 (Inner mitochondrial membrane protein 1) (Mitofilin homolog 1) (Q22505)
Organism: Caenorhabditis elegans
Function: Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:20578245}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:20578245}. Note=Localized to cytoplasmic foci in embryos and gonads. Evenly distributed between the periphery and the cristae regions of the mitochondrion inner membrane. {ECO:0000269|PubMed:20578245}.
Interaction partners:
- MICOS complex subunit MIC19
- MICOS complex subunit MIC27
- MICOS complex subunit Mic10
- MICOS complex subunit MIC13
- MICOS complex subunit MIC60-2
- SAM50-like protein gop-3
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- ATP synthase subunit beta, mitochondrial
- Saccharopine dehydrogenase
- ATP synthase subunit alpha, mitochondrial
Sequence:
MFRIASKRSVSQTLKRARQQSNQAAAPPKPPVQPPKKSGGGKGLALVGATVVGAGGVVGYAYVDPEFRHKVESTVPPVKQVFDAVLGESSLQKTKQQIGDLKDAVVNAVPKKKEVLPPLELAPLPPVLPREPTHVDPVDVRKDVTPMIPKPSPDVVFAKNQQLEEKLKIAIHSAEGKVRLATEAKLKTINAINEHASILKQTVDDAKHANWENVTSALQRAEAEARVDSGQEVDGRNYIDNLRKIVNDGKRDSTTATNPLLLNAQETANKLSHQLDEINALVNKSRQESAVLNQYKDLIEKSRQQFALEMKSILPNVDIHAKDKNLNEDELNALIAHAHLKVDQLRCQLSDQQVREELHISKALEEQRLADERIASEKLSIEMSRVGRQNELEIERALVESRSSWEGELENQLKRTASAHSEHLEQVIRTQRQLFEIEQNQKVEEAVLQERNLHSKQVGAALSRLEGIEEALGSRVALDNENRRAKQFWIACHNLIDTLKHGNKAGNNIDERRLPLNESLNLLKEVNPEDEFVNAIIDSFPKQATTVGTYTEQDLKNRFEQLYKIGRKTASIDENGGTLGAYFWSYVKSLFLVDMPQQYGNLDAIDVNNTDNYEILSRAKQYVHNGDLDKAIRVVQLLKGQPAHLARDWIVDTRSYLESRLLAQLLVAHAAVSSIRSTY
Protein: Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (Q9ET64)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Sphingomyelin phosphodiesterase 3
- Ceramide glucosyltransferase
- Sphingomyelin phosphodiesterase
- Sphingomyelin phosphodiesterase 4
- Neutral sphingomyelinase activation associated factor
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Ceramide synthase 5
- Ceramide kinase
- Ceramide synthase 6
Sequence:
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK
Protein: Monoglyceride lipase, putative (Q57Y40)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyltransferase
- glycerol kinase
- glycerol kinase
- glycerol kinase
- glycerol kinase
- Monoglyceride lipase, putative
- Lipase-like protein, putative
- Fungal lipase-type domain-containing protein
- Fatty acyl CoA synthetase 2
- Long-chain-fatty acid-CoA ligase protein, putative
Sequence:
MGCCSCCIDENHDLKYATPDREPPDPELFPHYLQNKQGLWLHFTEWAPPRDVPNVRGVLFVVSGLGEHTARYGGVGRYFSREGYHVFCMDNQGAGASEGERLYVVDFEDFVDDIFLFRRRVFSLYPEYAKLPRFLLGHSMGGLIATHVSLRDPTSFAGVVLSGPALEPDPKIATPFKRWLVGVLSSCAPKFGVDSIDPKLASTNRQVVELMEQDPVYFKVKLTTRWAKTMLDAMESVWEHVERATYPLLIVHGAKDALCPVSGSRRLFSCVPTTDKQLIEYPGLGHEVLTEVRWREVLGDILKFLNAHCQ
Protein: endothelin-converting enzyme 1 (EC 3.4.24.71) (Q923T6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004250}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004194}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004194}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MNVALHELGGGGSMVEYKRAKLRDEESPEITVEGRATRDSLEVGFQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFHAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
Protein: E3 ubiquitin-protein ligase ITT1 (EC 2.3.2.31) (Q04638)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA.
Interaction partners:
- Eukaryotic peptide chain release factor GTP-binding subunit
- E3 ubiquitin-protein ligase HEL1
- Eukaryotic peptide chain release factor subunit 1
- Putative ATP-dependent RNA helicase ECM32
Sequence:
MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFKISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHGYNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSGCYGRLFEGMPGTET
Protein: E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20) (P08152)
Organism: Mus musculus (Mouse)
Function: Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 and of HOXB3 in r3 and r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB.
Subcellular location: Nucleus {ECO:0000269|PubMed:17938205}.
Interaction partners:
- NGFI-A-binding protein 2
- Early growth response protein 3
- Histone lysine acetyltransferase CREBBP
- Histone acetyltransferase p300
- NGFI-A-binding protein 1
- Protein c-Fos
- CCAAT/enhancer-binding protein beta
- Protein FosB
- Early growth response protein 1
- Chromodomain-helicase-DNA-binding protein 4
Sequence:
MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAASSVTIFPNGELGGPFDQMNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPELDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPSTTSTSSLAYQPPPSYPSPKPAMDPGLIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPGAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSAPPSAQSSASGPGGSQAGGSLCGNSAIGGPLASCTSRTRTP
Protein: Epididymis secretory sperm binding protein (A0A384MEJ3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA
Protein: Structural maintenance of chromosomes protein 1 (DA-box protein SMC1) (P32908)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular location: Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Interaction partners:
- Sister chromatid cohesion protein PDS5
- Sister chromatid cohesion protein 1
- Sister chromatid cohesion protein 2
- Structural maintenance of chromosomes protein 3
- Cohesin subunit SCC3
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- Separin
- N-acetyltransferase ECO1
- Condensin complex subunit 3
- Condensin complex subunit 1
Sequence:
MGRLVGLELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVRSNHLRSNILKDLIYRGVLNDENSDDYDNEGAASSNPQSAYVKAFYQKGNKLVELMRIISRNGDTSYKIDGKTVSYKDYSIFLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKIEKLSKSATESIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDKLSALNSEISSLKGKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISHIEKRIESLQKDLQRQKTYVERFETQLKVVTRSKEAFEEEIKQSARNYDKFKLNENDLKTYNCLHEKYLTEGGSILEEKIAVLNNDKREIQEELERFNKRADISKRRITEELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSDIESANNQEYDLNFKLRETLVKIDDLSANQRETMKERKLRENIAMLKRFFPGVKGLVHDLCHPKKEKYGLAVSTILGKNFDSVIVENLTVAQECIAFLKKQRAGTASFIPLDTIETELPTLSLPDSQDYILSINAIDYEPEYEKAMQYVCGDSIICNTLNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDANNRWDKEEYQSLMSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQKRSLDENRLEIKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGFTIKEYENHSGELMRQQSKELQQLQKQILTVENKLQFETDRLSTTQRRYEKAQKDLENAQVEMKSLEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDILEDMNSNLQVLKRERDGIKEDIEKFDLERVTALKNCKISNINIPISSETTIDDLPISSTDNEAITISNSIDINYKGLPKKYKENNTDSARKELEQKIHEVEEILNELQPNARALERYDEAEGRFEVINNETEQLKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVELAGGNASLTIEDEDEPFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLDEVDAALDITNVQRIAAYIRRHRNPDLQFIVISLKNTMFEKSDALVGVYRQQQENSSKIITLDLSNYAE
Protein: Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25) (A0A087WVB9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|HAMAP-Rule:MF_03010}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03010}.
Interaction partners:
Sequence:
MAMFEQMRANVGKLLKGIDRYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ