wanglab/gogpt-training-data huggingface dataset:
Protein: Transposon Ty1-GR3 Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)] (Q12316)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSYASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNSNKRIIAKLKMQYDTKIINLGESDDEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPNGRKLGAPGQPGLYINQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: Transcriptional activator protein UGA3 (P26370)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2).
Subcellular location: Nucleus {ECO:0000269|PubMed:2109179}.
Interaction partners:
- 4-aminobutyrate aminotransferase
- Succinate-semialdehyde dehydrogenase [NADP
- Transcriptional activator protein DAL81
- GABA-specific permease
- Nitrogen regulatory protein DAL80
- Glutamate decarboxylase
- NAD-specific glutamate dehydrogenase
- Acyl carrier protein, mitochondrial
- RNA polymerase I-specific transcription initiation factor RRN11
- Calmodulin
Sequence:
MNYGVEKLKLKYSKHGCITCKIRKKRCSEDKPVCRDCRRLSFPCIYISESVDKQSLKKIKADIQHQLISKKRKHAPDSAQKAAVATRTRRVGSDEQDNQVYLSKPLEDCISQKLDSMGLQLYNYYRSHLANIISIAPMNQNYYLNIFLPMAHENDGILFAILAWSANHLSISSSNELRKDEIFVNLANKYTYMSLSHLKTNEGSSACAKLGFLYSLAQILILCGSEICQGDVKFWKILLNIGKNLIENHVGKDVSRILTTTTEEPSLEERIIFPNFNSVVKYWLIVNFIYHDILNFNTTSFPIEQYEKFFQRDQNSLPSSANFIESIDSPIEEIDPLIGINKPILLLLGQVTNLTRFLQTMEQEEMLEHGDKILSLQVEIYKLQPSLMALEHLDDEKKFYYLELFEIMKISTLMFFQLTLLKIDKDSLELQILRNKLDSKLDKVIGTFLEGSLCFPLFIYGVCIQVEDMEKKIDLEAKFDDILKRYKCYNFQNARLLIRKIWQNEADGISEHDLVHMIDELDYNINFA
Protein: FLII actin remodeling protein (J3KS54)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRNMSGRAGCAWSARAMSSTPLPAASTPGAPSARPWPKTGWHSPRLGEEEEGASSTVC
Protein: Disease resistance protein Pik-2 (Pik-2 blast resistance protein) (P0DO07)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Disease resistance (R) protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Contribution of Pik-1 is required to recognize the effector avirulence protein AVR-Pik.
Interaction partners:
Sequence:
MELVVGASEATMKSLLGKLGNLLAQEYALISGIRGDIQYINDELASMQAFLRDLSNVPEGHSHGHRMKDWMKQIRDIAYDVEDCIDDFAHRLPQDSISDAKWSFLLTKIYELWTWWPRRVIASNIAQLKVRAQQIADRRSRYGVNNPEHLDSSSSARTRAVNYEIAEYQVTSPQIIGIKEPVGMKTVMEELEVWLTNPQAENGQAVLSIVGFGGVGKTTIATALYRKVSEKFQCRASVAVSQNYDQGKVLNSILSQVSNQEQGSSTTISEKKNLTSGAKSMLKTALSLLRGNCICQPENDGNPDNTPIRLQETTDDDQNPRKLEQLLAEKSYILLIDDIWSAETWESIRSILPKNNKGGRIIVTTRFQAVGSTCSPLETDRLHTVDFLTDDESQNLFNTSICESKIRKDSNKVDEQVPEEIWKICGGLPLAIVSMAGLVACNPRKACCDWSKLCKSLFPEQETPLTLDGVTRILDCCYNDLPADLKTCLLYLSIFPKGWKISRKRLSRRWIAEGFANEKQGLTQERVAEAYFNQLTRRNLVRPMEHGSNGKVKTFQVHDMVLEYIMSKSIEENFITVVGGHWQMTAPSNKVRRLSMQSSGSNRGSSTKGLNLAQVRSLTVFGNLNHVPFHSFNYGIIQVLDLEDWKGLKERHMTEICQMLLLKYLSIRRTEISKIPSKIQKLEYLETLDIRETYVRDLPKSIVQLKRIISILGGNKNTRKGLRLPQEKSKKPIKNPSPQGKTKEPAKKGFLSQEKGKGAMKALRVLSGIEIVEESSEVAAGLHQLTGLRKLAIYKLNITKGGDTFKQLQSSIEYLGSCGLQTLAINDENSEFINSLGDMPAPPRYLVALELSGKLEKLPKWITSITTLNKLTISVTVLRTETLEILHILPSLFSLTFAFSLSAAKQDQDIIKDILENNKLDSDGEIVIPAEGFKSLKLLRFFAPLVPKLSFLDKNAMPALEIIEMRFKDFEGLFGIEILENLREVHLKVSDGAEAITKFLVNDLKVNTEKPKVFVDGIVTA
Protein: Leucine-rich repeat protein (LRRP) (Q387G4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHAGTPTTRAATPVHSKHQPLLMPARKRALSPIPQRLQQRPSFGVASPKRNMLFQRVKAQDEASVSLPDETIRELRNTRSLFLCCRNLLSFGHIQYLEHMTNLSSLNVHMNAISRLECLFNLRNLAELDVSANELRDVDEGAFVGLCKLRRLNLSSNFLTSLSGFKHLPALEWLSVSFNELEDLGEVQQLPCPQKLVYLDVCGNKIPSVANLVKPLGKCCDLAELRVEVPRAALLLPTTPPQLQLRENPFCATESNYVERILAKFKRLKVLNGVPCGCDLTEDLHVSSYSAAASEGPLTKDNGISVRECKLHPITAADSRDTASRGELRDAGHCRKEVVGAADTSGVAGNEVRNSNDCDGSGSFLNVVEITSSSEGLTSPVCVSRGVTTDLSVPPHRVMHLSSTDDVAAQKVLEDDNAHLKLSLRRLQEQLSLRMALEEDLRRSLEEARRNHASLVESSEVESKRFGRQIDALKDELSRRAQESGVLERQHRANLEKQMKNHKAAMRELRQREAVRAAQDLEEKLSQVHKEADKRSAELQERVDSTLKQNEWLQKMNVQIEERVKQLQAEFLLCEQSAKLCEKRYLLMLEECSSRHAVEVAALNALVSSGAAYLHLWQHHGRMLLVSHSNNQQEWKEYTSKLKKHYEGIVTQLHAAQAARGTRFDVACDPIVVSNENLRMDEEVPKLQEALSLARESEQLVSRENVRLLSCVAAMEKELADSVKLLQEHQAAARSAQDEFTRERDNLLRTLHNLRDTIRKKDTAYDELEAEAEAKIDEKRAIIAKLEARLEEARESAECQREEAAKLLRVEEELRRVKAEFSAIEKDASLQTTTQQPQLKELMDALDDSKRKLATLTAREHQQSVKLARAAEALMLVRRQLVRLDEVNTSLTNELSEREAALRAATTENRHLQQQLQEIQETERARHRAALQTLSQLMVGGIEGATRA
Protein: Vacuolar protein sorting-associated protein 45 (Q09805)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Vacuolar protein sorting-associated protein involved in Golgi-to-vacuole protein transport.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Vacuolar segregation protein pep7
- t-SNARE affecting a late Golgi compartment protein 2
- t-SNARE affecting a late Golgi compartment protein 1
- Syntaxin pep12
- Vesicle transport v-SNARE protein vti1
- Protein MTO1 homolog
- Uncharacterized protein C24B11.08c
- Integral membrane protein sed5
- AP-1 complex subunit sigma-1
- Syntaxin-like protein fsv1
Sequence:
MDLVSASQSYFKRIFQEVSDLKILLLEEDTTKIVSSCITQSNLLEQQIYLTVLLGNKREKLRHLKCVAFLRPTPTTLRLLCEELRDPKYAEYHLYFTNVIPKSFLERLAESDDFEAVKSIQEFFLDYLVVNNDLASFNIPHIIEDSPDNWQDGAFHRTHQGIISLLLSLKKKPVIRYDNNSLLCLKLAEEVSYTIQHESQLFNFRKPDTAPILLLLDRKNDPITPLLTQWTYQAMVHELFGIDNGRVSFSNSTSDNEKSTEIVLNPTLDPFYKETRFDNFGDLGVKIKDYVSHLQTKSTKKASEIESIADMKQFLEAYPEYRRLSGNVSKHVSLVSEISQVVQRENLLEVGEVEQSLVCNEPQSTDFNDIQRLLFSNISENTKLRLAALYSLRFERIDPAKVSALQQMLIAGGVNPLKVSVIPTLLHVAGYSFRQGDVFPPSNLFSRARSGLKGLRGVENVYIQHNPFLKSILLDLIQGRLKETTHPFLNSETRAQTSNEKPQDIIVVIVGGATYEEAHFVSEFNATQPGVRIILAGTTILNSTAYIDDIMYMSTRIK
Protein: U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) (Q9Y5J1)
Organism: Homo sapiens (Human)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Interaction partners:
- HEAT repeat-containing protein 1
- U3 small nucleolar RNA-associated protein 4 homolog
- U3 small nucleolar RNA-associated protein 15 homolog
- WD repeat-containing protein 75
- Nucleolar protein 56
- U3 small nucleolar RNA-associated protein 6 homolog
- Neuroguidin
- WD repeat-containing protein 46
- KRR1 small subunit processome component homolog
- Bystin
Sequence:
MPPERRRRMKLDRRTGAKPKRKPGMRPDWKAGAGPGGPPQKPAPSSQRKPPARPSAAAAAIAVAAAEEERRLRQRNRLRLEEDKPAVERCLEELVFGDVENDEDALLRRLRGPRVQEHEDSGDSEVENEAKGNFPPQKKPVWVDEEDEDEEMVDMMNNRFRKDMMKNASESKLSKDNLKKRLKEEFQHAMGGVPAWAETTKRKTSSDDESEEDEDDLLQRTGNFISTSTSLPRGILKMKNCQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVRLVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMYRLHHYSDF
Protein: Protein argonaute 9 (Q84VQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates preferentially with small RNAs of 24 nucleotide in length with a 5' terminal adenosine. Interacts with 24 nucleotide sRNAs derived from transposable elements (TEs). Required to silence pericentrometric-located TEs in female gametes and their accessory cells. Necessary to inactivate a significant proportion of long terminal repeat retrotransposons (LTRs) in the ovule. Required to specify cell fate in ovule. Involved in the control of female gamete formation by restricting the specification of gametophyte precursors in a dosage-dependent, non-cell-autonomous manner. Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO9 function in RNA silencing.
Interaction partners:
- Endoribonuclease Dicer homolog 3
- Dicer-like protein 4
- Endoribonuclease Dicer homolog 2
- Endoribonuclease Dicer homolog 1
- DNA-directed RNA polymerase IV subunit 1
- DNA-directed RNA polymerase V subunit 1
- RNA-dependent RNA polymerase 2
- RNA-dependent RNA polymerase 6
- DNA
- Small RNA 2'-O-methyltransferase
Sequence:
MDSDEPNGSGLPPPPPFVPANLVPEVEPVKKNILLPMARPRGSGSKGQKIPLLTNHFGVKFNKPSGYFFHYSVAINYEDGRPVEAKGIGRKILDKVQETYQSDLGAKYFAYDGEKTLFTVGALPSNKLDFSVVLEEIPSSRNHAGNDTNDADRKRSRRPNQTKKFMVEISYAAKIPMQAIASALQGKETENLQDALRVLDIILRQSAARQGCLLVRQSFFHNDVKNFVPIGGGVSGCRGFHSSFRTTQGGLSLNIDTSTTMIVQPGPVVDFLLANQNKKDPYGMDWNKARRVLKNLRVQITLSNREYKISGLSEHSCKDQLFTWRKPNDKGEFEEVEITVLNYYKERNIEVRYSGDFPCINVGKPKRPTYFPIEFCNLVSLQRYTKSLTNFQRAALVEKSRQKPPERMASLTKGLKDSNYNADPVLQDSGVSIITNFTQVEGRILPTPMLKVGKGENLSPIKGKWNFMRKTLAEPTTVTRWAVVNFSARCDTNTLIRDLIKCGREKGINVEPPFKDVINENPQFRNAPATVRVENMFEQIKSKLPKPPLFLLCILAERKNSDVYGPWKKKNLVDLGIVTQCIAPTRLNDQYLTNVLLKINAKLGGLNSLLAMERSPAMPKVTQVPTIIVGMDVSHGSPGQSDIPSIAAVVSSRQWPLISKYKACVRTQSRKMEMIDNLFKPVNGKDEGMFRELLLDFYYSSENRKPEHIIIFRDGVSESQFNQVLNIELDQMMQACKFLDDTWHPKFTVIVAQKNHHTKFFQSRGPDNVPPGTIIDSQICHPRNFDFYLCAHAGMIGTTRPTHYHVLYDEIGFATDDLQELVHSLSYVYQRSTTAISVVAPVCYAHLAAAQMGTVMKYEELSETSSSHGGITTPGAVPVPPMPQLHNNVSTSMFFC
Protein: Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)] (P10600)
Organism: Homo sapiens (Human)
Function: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
Subcellular location: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-3]: Secreted {ECO:0000250|UniProtKB:P01137}.
Interaction partners:
- TGF-beta receptor type-1
- TGF-beta receptor type-2
- Endoglin
- Transforming growth factor beta receptor type 3
- Transforming growth factor beta-1 proprotein
- Latent-transforming growth factor beta-binding protein 1
- Activin receptor type-1-like
- Decorin
- Fibromodulin
- Latent-transforming growth factor beta-binding protein 3
Sequence:
MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
Protein: Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin) (P55283)
Organism: Homo sapiens (Human)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Catenin delta-1
- Cadherin-2
- Catenin alpha-1
- Killer cell lectin-like receptor subfamily G member 1
- Catenin beta-1
- Cadherin-20
- Junction plakoglobin
- Cadherin-19
- Cadherin-7
- Cadherin-8
Sequence:
MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED
Protein: von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Q70UZ7)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted.
Interaction partners:
Sequence:
MPPLLLLPAIYMLLFFRVSPTISLQEVHVNRETMGKIAVASKLMWCSAAVDILFLLDGSHSIGKGSFERSKRFAIAACDALDISPGRVRVGALQFGSTPHLEFPLDSFSTRQEVKESIKGIVFKGGRTETGLALKRLSRGFPGGRNGSVPQILIIVTDGKSQGPVALPAKQLRERGIVVFAVGVRFPRWDELLTLASEPKDRHVLLAEQVEDATNGLLSTLSSSALCTTADPDCRVEPHPCERRTLETVRELAGNALCWRGSRQADTVLALPCPFYSWKRVFQTHPANCYRTICPGPCDSQPCQNGGTCIPEGVDRYHCLCPLAFGGEVNCAPKLSLECRIDVLFLLDSSAGTTLGGFRRAKAFVKRFVQAVLREDSRARVGIASYGRNLMVAVPVGEYQHVPDLIRSLDSIPFSGGPTLTGSALLQVAEHGFGSASRTGQDRPRRVVVLLTESRSQDEVSGPAAHARARELLLLGVGSEILQAELVKITGSPKHVMVHTDPQDLFSQIPELQRRLCSQPRPGCQAQSLDLVFLLDASASVGRENFAQMQSFIRKCTLRFDVNPDVTQVGLVVYGSRVQTAFGLDTHPTRAAVLRAMSQAPYLGGVGSAGTALLHIEDKVMTVQRGARPGVPKAVVMLTGGSGAEDAAVPAQKLRGNGISVLVMSVGAVLREAVRRLAGPRDSLIHVAAYTDLPYHQDMLIEWLCREARLPVNLCKPSPCMNEGTCVLKNGSYRCECRGGWEGPHCENRILRGDAPMARSFHQEPAGLQGPTPSQQAPKHLRIGKALSSAK
Protein: Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] (P97297)
Organism: Mus musculus (Mouse)
Function: AM and PAMP are potent hypotensive and vasodilatator agents.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P35318}.
Interaction partners:
- Receptor activity-modifying protein 3
- Calcitonin gene-related peptide type 1 receptor
- Receptor activity-modifying protein 2
- Receptor activity-modifying protein 1
- Calcitonin receptor
- Islet amyloid polypeptide
- Calcitonin gene-related peptide 2
- Protein ADM2
- Atypical chemokine receptor 3
- G-protein coupled receptor 182
Sequence:
MKLVSITLMLLGSLAFLGADTAGPDTPSQFRKKWNKWALSRGKRELQASSSYPTGLADETTVPTQTLDPFLDEQNTTGPLQASNQSEAHIRVKRYRQSMNQGSRSNGCRFGTCTFQKLAHQIYQLTDKDKDGMAPRNKISPQGYGRRRRRSLLEVLRSRTVESSQEQTHTAPGPWAHISRLFRI
Protein: Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) (Q8BZQ7)
Organism: Mus musculus (Mouse)
Function: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
Interaction partners:
- Fizzy-related protein homolog
- Cell division cycle protein 16 homolog
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 10
- Cell division cycle protein 20 homolog
- Anaphase-promoting complex subunit 1
- Cell division cycle protein 23 homolog
- Cell division cycle protein 27 homolog
Sequence:
MEAEGVAVAAAAAAAAAAATIIASDDCDSRPGQELLVAWNTVSTGLVPPAALGLASSRTSGAVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQNDLQGNIATEFWNAIALRENSVDEPQCLGLLLDAFGLLESRLDPYLHSLELLEKWTRLGLLMGAGAQGLREKVHTMLRGVLFFSTPRTFQEMVQRLYGRFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCGSDKQQCWCRQALEQFNQLSQVLHRLSLLERVCAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDNPTRPTSPEAGNTLRRWRCHVQRFFYRIYATLRIEELFSIIRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKVALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPACLETGQDSEDDSGEPEDWVPDPVDADPVKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVLLYFQNQASWTLEELSKVVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWAYIQAMLTNLESLSLERIYSMLRMFVMTGPALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLPKNSN
Protein: Cyclin-B2-1 (Cyc2a-At) (Cyclin-2a) (G2/mitotic-specific cyclin-B2-1) (CycB2;1) (Q39068)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B1-1
- Cell division cycle 20.4, cofactor of APC complex
- Wee1-like protein kinase
- Cyclin-dependent kinase A-1
- Cell division cycle 20.3, cofactor of APC complex
- Cell division cycle 20.5, cofactor of APC complex
- Cyclin-dependent kinase B2-2
- F10B6.17
Sequence:
MVNSCENKIFVKPTSTTILQDETRSRKFGQEMKREKRRVLRVINQNLAGARVYPCVVNKRGSLLSNKQEEEEGCQKKKFDSLRPSVTRSGVEEETNKKLKPSVPSANDFGDCIFIDEEEATLDLPMPMSLEKPYIEADPMEEVEMEDVTVEEPIVDIDVLDSKNSLAAVEYVQDLYAFYRTMERFSCVPVDYMMQQIDLNEKMRAILIDWLIEVHDKFDLINETLFLTVNLIDRFLSKQNVMRKKLQLVGLVALLLACKYEEVSVPVVEDLVLISDKAYTRNDVLEMEKTMLSTLQFNISLPTQYPFLKRFLKAAQADKKCEVLASFLIELALVEYEMLRFPPSLLAATSVYTAQCTLDGSRKWNSTCEFHCHYSEDQLMECSRKLVSLHQRAATGNLTGVYRKYSTSKFGYIAKCEAAHFLVSESHHS
Protein: PCIF1 WW domain-containing protein (Q57YM3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKRGSDGCGPDASHPSLCFHREVLTCLQWSVIRRDFLEKLRFTPLLRFAEPNKLWRHSNEALGKWILSQVARDTSNGMTSNDIIASTSSSCITPSLSCAMSSFFPSDDALSRGTYDEQLIRDLSMKCTTPSNQETIKCITQLVKEFNLAERCKRATSEVQRQMANVTLSSVCVPVIRTIAANDEKNRTAVQRRIQGAIATIDVVWSRNIPRDARSGCPQVSIPLAAYKKLDMSYRQFGGKSDEEKYPRLSYEKCFTLRAATLALRYECCLATGSLQLCADLRLKQHLHANGYRVIDLCASPINAYMGEPKEGSYLVGESRAEEKSSSEVNDSFIGCENTPNHFCSAFPDTDCYFGSLGSVLKFDVVQAYNTPQINPDKRPLLLTLDVPYDEDLCERIFLKLVSDMKRVETELATMEGSVNTDLVVADYVLVLPLWWEVPLEIKKRLFSCPNGSGEEASATGNIEGKEDEEEVLKRVIRERSALLKEGHVLPYEWPVKLAAAAGEKWPCFDGVFVGGSYEYFCTITNKRLSGVTATEVIGLEQPRSVRGGNSLPSLRTSLDSFYGRQVTAAGR
Protein: Zinc finger protein sens (Protein senseless) (Q9N658)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.
Subcellular location: Nucleus {ECO:0000269|PubMed:10975525}.
Interaction partners:
- Protein atonal
- Achaete-scute complex protein T4
- Achaete-scute complex protein T5
- Homeotic protein distal-less
- Protein wingless
Sequence:
MNHLSPPPSPHSQQPSPAGLGCHGAALDKQWMQRASAFNTVIASAAAQKLNGRDLPFLYNPLLYSSALLWPQFLLSSATALGTPLTPMTPKSPASVVLGQRDRDFALTPEKEHELQMNNNNENSKQDYQEQDEDMPLNLSTKERITSDDSNRDQYHSSSNNSSRSSSSSEVEQLHPMTSLNVTPPPLSAVNLKSSSTPQQQRQRSQGNIIWSPASMCERSARREQYGLKMEEQGDEEEHQVDPIVRKFKYERRTASISSLQSPISSLSAPASNAVQDLEFEVAQQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHRIKDEQQQDNRSAAALMNLVAAAEFGYMRNQHQQPQQQQQQQLHHQQQPQQHQHQQQHPDSTATDVARRSSSSSSYQGENEEKRSGRNFQCKQCGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRHEEAPPVEDLKPLKMEVSSSSC
Protein: 8-oxoguanine DNA glycosylase (H7C1D7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGVPVPAEGLLTSASAFQSPLRSRQPEADRR
Protein: CDC5 pindle pole body anchor protein 1 (CDC5 SPB anchor protein 1) (Q06616)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Specialized component of the nuclear membrane that may be involved in the connection of the spindle pole body (SPB) to the nuclear envelope.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:15282802, ECO:0000269|PubMed:32553169}; Peripheral membrane protein {ECO:0000269|PubMed:15282802, ECO:0000269|PubMed:32553169}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:15282802, ECO:0000269|PubMed:32553169}. Note=Localization is controlled by phosphylation. {ECO:0000269|PubMed:32553169}.
Interaction partners:
- Cyclin-dependent kinase 1
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
Sequence:
MGIQEKTLGIRKERKLVVVPRERNHVRHASQRTRSKNYKNISKKRAQQHAFGFNIAKTLAKIQAFVWGSPADEEEESVVPLSKNSQDCVPLQWQAKFAQLRQQLHSTQKELQFVKEKCHLLQSVLDDANIDQRYLESRRDMKNIERDNLKPTENLPPSPVRAVNPLVTSSPIHMSPLQSRQRPVSSLQPPKGPNFYAKYPKLPQTNILRESPTEDSVPHAE