wanglab/gogpt-training-data huggingface dataset:
Protein: Radical SAM core domain-containing protein (Q9WY26)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Interaction partners:
Sequence:
MYILFREMKNNWYSLAALLSTIYSRHLDVEARPVKFEEIKKFPPEKTIVAYSFMSFDLDTVREEVKTLKERGYTLIAGGPHVTADPEGCLRMGFDHVFTGDGEENILKFLMGERKKIFDGISKRVNLNHYPPFLPSKGIYMPIEITRGCPFSCAYCQTPIIAGRRVRHRDVDVVVHYAKLGVKHGRKLARFIAPNSFGYGSKNGVTPNVEKIEELLYGLKKVGIEEIYFGTFPSEVRPESVTDEVLKVVKKYVNNRSIVIGAQSGSDRILKIIKRGHTVEQVEEAIEKISLHGFIPHVDFIFGFPFETEEDVEKTFSFIVKIVERYGAKIHAHTFMPLPGTELFNAGPGRLTEVHYKFLGRLASKGILDGYWMKQEMLARKVYEIASGGSTDVTSDR
Protein: H(+)-transporting two-sector ATPase (EC 7.1.2.2) (Mitochondrial protein YMF19) (A0PJ32)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004304}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004304}.
Interaction partners:
Sequence:
MPQLDKLTYFSQFFWLCLFFFSFYILLLNNNNGILGISRILKLRNQLLSHRGNKIRFKDPKNLEDILRKGFSTGLSYMYSSLSEVSQWCKTVDYLGKRRKITLISDFGEISGSRGMERQILYLISKSSYNTSSSRITCWKKIMLTHVLHGQGSII
Protein: Glutathione-independent glyoxalase hsp3101 (EC 4.2.1.130) (Glyoxalase 3 homolog 1) (Heat shock protein 31 homolog 1) (O74914)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24758716}. Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24758716}.
Interaction partners:
- Probable hydroxyacylglutathione hydrolase glo2
- Lactoylglutathione lyase
- Probable hydroxyacylglutathione hydrolase SPCC13B11.03c
- Glutathione-independent glyoxalase DJ-1
- Putative D-lactate dehydrogenase C713.03, mitochondrial
- 2-hydroxyacid dehydrogenase homolog 2
- Copper amine oxidase-like protein cao2
- Threonine dehydratase, mitochondrial
- Copper amine oxidase 1
- Tryptophan synthase
Sequence:
MASEGKVLLVASSYYGPFYPDGMNTGVHFAELLIPYQVFREAGYEVQLTSETGKCKFDDHSIKKSALGEVERDAFDNKDNEFWYALKDIKPADKINYKEFCIMFIAGGHAAMFDLPHATNLQTLAQQIYASNGVLAAVCHGPVMLPFVDDTKSPEGRSVVYGKKVTAFNSTGELVMGVSSALRERNMQDLNSLFREAGAEFVDPPTPMSDFTQVDGRIVTGVNPMSAKSTAEAAIKVSQSLRKT
Protein: Tubulin gamma chain (Gamma-tubulin) (P54401)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: Tubulin is the major constituent of microtubules (Probable). The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9497056}. Nucleus {ECO:0000269|PubMed:15500912}. Note=Expressed during all cell cycle phases with maximal expression at the S/G2 phases (PubMed:9497056). In the nucleus, forms a ring-like structure surrounded by six equally-spaced gamma-tubulin-rich patches (PubMed:15500912). {ECO:0000269|PubMed:15500912, ECO:0000269|PubMed:9497056}.
Interaction partners:
Sequence:
MPREIITLNVGQCGNQLGSEFFKKICSEHGILPDGSLSTNEFIDDRKDVFFYQADDQRYVPRSINIDLEPRVLDSIRTSEWSNFYNPENFIIPTNNGAGNSWANGYYTTEKMSEIEEIIDREVEHCDSLEGFFFCHSICGGTGSGLGSKIMEMISEKYPKNILTSFSVMVKENPDVVVSPYNSILTLRRLITECQSVVVFDNSALADITHTQFGVDEATVFDMNSIISSSMSAFTANLRFPSTLYNSLNSLMIHLCPSRFSHFLMTSYTPLRQVNQISSRTSAIDVMKRLIQPQNIMARTRLKEGKYISMCDFFQGDVSYDEINEALQRFTDRRLAEFVPWNKEAIKVVHTRVSPLVKRGNRMSGMLLANNTSIRYYFQDILKAFDQMFKKRVYLESYREQFHDNFQEFEESKEIVKCVIEEYAKAESIEYSDYSYPIHKYLKGIAKEKIAE
Protein: Transcription factor S4 (TFS4) (Q97X43)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: A potent inhibitor of RNA polymerase (RNAP) probably involved in viral defense. Destabilizes the transcription pre-initiation complex of TBP, TFB, DNA and RNAP, inhibits abortive transcription initiation, productive initiation and transcription elongation. Increases the RNAP KM for NTPs about 50-fold. Overexpression of TFS1-tip4 (TFS1 with the active tip of this protein, phenocopies this protein) in S.acidocaldarius MW001 leads to severe growth inhibition. When bound to RNAP induces conformational changes that widen the DNA-binding channel, probably destabilizing the interaction of DNA with RNAP.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo11
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase subunit Rpo10
- DNA-directed RNA polymerase subunit Rpo3
- DNA-directed RNA polymerase subunit Rpo7
- TATA-box-binding protein
- Transcription factor E
- DNA-directed RNA polymerase subunit Rpo1C
Sequence:
MRFCPKCGSFLKVKGNKMVCSKCGYSDHDVEKVILKENVAHENDKTIIADGETIEGRVAISLCPRCGSVRAILLNKKKRLYRCMTCNFVYNI
Protein: Coiled-coil domain-containing protein 152 (Q4G0S7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDQSSEGCMKKISSVNLDKLINDFSQIEKKMVETNGKNNILDIQLEKSNCLLKVMQAKEVSIKEECATLHNIIKGLQQTIEYQQNLKGENEQLKISADLIKEKLKSHEQEYKNNIAKLVSEMKIKEEGYKKEISKLYQDMQRKVELNEEKHKELIEKKEMEISELNAKLRSQEKEKQNEIIKLQLEFDAKLARVQTKSKSYQDSTVLPQSIYRRKLQHFQEEKNKEIAILRNTIRDLEQRLSVGKDSHLKRRRF
Protein: Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (P41094)
Organism: Drosophila melanogaster (Fruit fly)
Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein eS17
- GEO07453p1
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS7A
- Small ribosomal subunit protein uS4
Sequence:
MSLVIPEKFQHILRIMNTNIDGKRKVGIAMTAIKGVGRRYSNIVLKKADVDLTKRAGECTEEEVDKVVTIISNPLQYKVPNWFLNRQKDIIDGKYWQLTSSNLDSKLRDDLERLKKIRSHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKK
Protein: Soluble Rieske-type ferredoxin domain-containing protein (Q383Q4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVEKHMYDGWSYERLRQQRNRAHFLLEEPYRFITVLLHHGKLYAIDSPCYHGSGPLGEGQIVDLEDMDTVVTSGDGKLGSSRVPCLRCPWHSYLISIETGELVEVLSVEGTKTGRENQADNDVAEEMPSYPLQHRFGTCGGATHVSRKGVVQRTHQVSLDEATGILTIEVEDEEVMRRRPLPSDKVAGDIKNGALTMQIFDIKARGLE
Protein: ATP-dependent Clp protease proteolytic subunit (F4HZE0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASCLQASMNSLLPRSSSFSPHPPLSSNSSGRRNLKTFRYAFRAKASAKIPMPPINPKDPFLSTLASIAANSPEKLLNRPVNADVPPYLDIFDSPQLMSSPAQVERSVAYNEHRPRTPPPDLPSMLLDGRIVYIGMPLVPAVTELVVAELMYLQWLDPKEPIYIYINSTGTTRDDGETVGMESEGFAIYDSLMQLKNEVHTVCVGAAIGQACLLLSAGTKGKRFMMPHAKAMIQQPRVPSSGLMPASDVLIRAKEVITNRDILVELLSKHTGNSVETVANVMRRPYYMDAPKAKEFGVIDRILWRGQEKIIADVVPSEEFDKNAGIKSASWRRTNRLTKITLAADCLVSNHLVNVNMRLGESYLKDLEIL
Protein: Alanine- and arginine-rich domain-containing protein (rA5D3) (Q91ZF7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Spermatogenesis-associated protein 32
Sequence:
MGLGDYSHCRQRMSRGLYGVSGRATLWSPAFHPVHRMPCGTWRIEAPEHVRASSPVLEHLRRQLERAFQRAAARGRARRAREAVAAVAAAAAAAREERSRARMECALARLRAELLELRFQNHQLARTLLDLNMKMQQLKKRQDQERASKPQSPQDEEMNPECGNA
Protein: UPF0449 protein C19orf25 (Q9UFG5)
Organism: Homo sapiens (Human)
Interaction partners:
- RAD50-interacting protein 1
- Centromere/kinetochore protein zw10 homolog
- Sec1 family domain-containing protein 2
- Vesicle transport protein USE1
Sequence:
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEDPPVPFRMMEDAEAPGEQLYQQSRAYVAANQRLQQAGNVLRQRCELLQRAGEDLEREVAQMKQAALPAAEAASSG
Protein: Nucleoporin Ndc1 (Q9VCG4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250}. Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Central core structure of the nuclear pore complex. {ECO:0000250}.
Interaction partners:
- Nuclear pore complex protein Nup205
- Nuclear pore complex protein Nup154
- Nuclear pore protein
- Nucleoporin Nup35
- Nucleoporin Nup188
- Nuclear pore membrane glycoprotein 210
- Aladin
- Nuclear pore complex protein Nup75
- Nucleoporin seh1
- Nuclear pore complex protein Nup88
Sequence:
MSASSSSNACKLLLLGRCLRAVLLSVAIQFLLLTVFLLFVNFQLLHPLAWVTGTLRLVASWYTWFASIPLVASVVLYGVILCQQHLSERRYCPTRYRWLLHYGPRKVLFLFAHLLVGLLTAWLYTGYLHTDYQHLKYKCYGQDCISAYNVYLLGIGMTAGCYYFVSVHMRKEISIEFPIVEQSRAEKMRELLYASLAKSLLSSLLPTISYTAVFCLFGPMVCHRLSHILSVDMDERLDGFFGVVTNVRLLFYGYLLTAQILSNMHLMRCFYGILLSEDLPLVVTKPRAAFAHEQDITLVAGLGVFNVYVVQCLAAHHFYKLALRKNSPQRAEIFQLTEPGNRPASWRSLCDQCLSILGSFTEELTESMQKISILKCAQSLPMPKITESLTTSLMAEKVLLRQYNQKHGIRPIVSPSREVAVESPADGIRHFPNWCERVSTQLEQSLQRLLQRVPGIVYLFNEPEGAKTTFLLANSLPVVYMTQALAQVCAASLKEDPYGVVQNDLPAIIKAINKLRNELDKLSSVIGNIRISSSSFNVLRCAVRRSLYAICLSFCDYLDDLLPPGEELRQLQDLVCQE
Protein: LD26301p (Q8T059)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSTRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA
Protein: Gag-Pro polyprotein (Pr76Gag-Pro) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Transframe peptide (TFP) (p8)] (P10274)
Organism: Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
Function: The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.
Subcellular location: [Matrix protein p19]: Virion {ECO:0000250|UniProtKB:P03345}.; SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000250|UniProtKB:P03345}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p15-pro]: Virion {ECO:0000250|UniProtKB:P03345}.
Interaction partners:
Sequence:
MGQIFSRSASPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKKFLKIALETPARICPINYSLLASLLPKGYPGRVNEILHILIQTQAQIPSRPAPPPPSSPTHDPPDSDPQIPPPYVEPTAPQVLPVMHPHGAPPNHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDPTAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLRREYQQLWLAAFAALPGSAKDPSWASILQGLEEPYHAFVERLNIALDNGLPEGTPKDPILRSLAYSNANKECQKLLQARGHTNSPLGDMLRACQTWTPKDKTKVLVVQPKKPPPNQPCFRCGKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPTIPEPEPEEDALLLDLPADIPHPKNLHRGGGLTSPPTLQQVLPNQDPASILPVIPLDPARRPVIKAQVDTQTSHPKTIEALLDTGADMTVLPIALFSSNTPLKNTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCLVDTKNNWAIIGRDALQQCQGVLYLPEAKRPPVILPIQAPAVLGLEHLPRPPEISQFPLNQNASRPCNTWSGRPWRQAISNPTPGQGITQYSQLKRPMEPGDSSTTCGPLTL
Protein: Transcription factor glial cells missing 2 (Protein glide-2) (Q9VLA2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor with a minor role promoting glial cell differentiation and a more significant role in hematocyte differentiation. Gcm2, together with gcm, is required for the proliferation of plasmatocyte precursors, the expression of Croquemort protein, and the ability of plasmatocytes to convert into macrophages.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00245}.
Interaction partners:
Sequence:
MVVINGYSFKTQQLLTQQPDHSQLTQFVQPQSQSTHSVHPGPSPGQQQAGGSMTMPSSSTGKGKREWDINDAIVPHVPDQEFDEFNEWSDGHVRHIYSLHNEEAKKHISGWAMRNTNNHNVNILKKSCLGVLVCSQHCTLPNGSKINLRPAICDKARRKQEGKACPNKSCRGGRLEIKPCRGHCGYPVTHFWRHSGNAIFFQAKGVHDHLRPDPKNSSVSKRAFGRVPLAGKSANGSVAKKSVIAGLVKQAKQQHSLISKVLKRPAVSNPLAHTALDIYQYNACGKCAGYSHCTCSYLDDSTTARSHQLSQSSNYGTNSWPLSGSESSAPCETAANVFTVNHQHITYNYPIYHATPAAATAAPSKSPSLPYACSISELAAYQQSSSGNSFAMGVPVHGHTQCQAVAYDSSPQLATPEPEFINYSQIKHLGGGGGQEEISCKAEPGPTIKYNATVETQPYVEDNYDYYYSPKAEYEMQQHHHQQQQSHQQFGGNQTAGHHYYESSSGYNGVSYFDTGTTTAPGNTATGNGLEVGYGGYYDHYTSYEQQMAVAGGFATAGGSTAPTVAAPPGHPPPPPPPPTLTYHHHHHHHLHHPAAATGLAPSVTH
Protein: V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1) (P50518)
Organism: Mus musculus (Mouse)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:29993276}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6PCU2}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q6PCU2}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit D
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit F
- V-type proton ATPase subunit d 1
- V-type proton ATPase subunit G 2
- V-type proton ATPase subunit H
Sequence:
MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKKDVDVQIDQEAYLPEEIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD
Protein: Sulfide:quinone oxidoreductase (B0LD08)
Organism: Arenicola marina (Lugworm) (Lumbricus marinus)
Interaction partners:
Sequence:
MASRKVSLVLTGRVLMCQQLPAQAARAAVAPHVASFSSSAPLETAKKMNYKMVVVGGGTGGCAAAHMFSRKLGKGNVAVIEPADTHYYQPLWTLVGGGLRKLDQSAQPMNKVLPGACDWIKDSAVQFDPDNNTVFTKHGYEVKYDFLVCAMGLQLNYHLIKGLPEAFDVDPSLCSNYWDKTVIKTRPAMEAVTEGNVIFTFPNSPIKCAGAPQKIMYLTEEYLRQSGKRDKTNVIYNTSLGVVFGVKKYAEALTKIVQERNIQVNFRHNLIEVRPDKKEAVFEHLDTKEQKVFDYAMLHVVPPMSTPEALWNSPLVNESGYVTVKRETLQHTKYPNVFGIGDNTDIPTAKTAAAVASQTGILKKNLAAAMNGHEIAGKQYDGYTSCPLVTSKNTVIMAEFDWDGQPLETFPINQAKERRTMFHFKADIFPQMYWHMLIKGYWHGPGLFRKAMHLGMSR
Protein: Dynein regulatory complex subunit 7 (Coiled-coil domain-containing protein lobo homolog) (Flagellar-associated protein 50) (A8JAM0)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:21289096}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:21700706}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}. Note=Associated with the outer doublet microtubules (OD). {ECO:0000269|PubMed:21289096}.
Interaction partners:
Sequence:
MAEGIGTFGTLSRDVLEERLMEARRTYRLNMGYAGLKQLPPGFVELVKKYNPHITELELSSNDLTDLPDELEEFRYLRILRLKYNQLKRIPAVVYRLPQLMVFDASGNRIQKVDDAIGHLSLLKELDVSGNEITTLPESLSTLPKLEVLQVENNRLELLPESLGELPGVIKMDLSTNNLRYLPASMGQLKKVQRIDVGNNLLTKVPPSMGHLKTLKEFNLRYNHLDDRYKAKVEEGLSKFLAFLREEEERERLEEIERLKPIGTPVGAYLEYRCKAEVGQVVKTDMGETTVDNRCWIRTGHTLTQVGSMLLIFGGQLQKDGSTTNDLFWMTMDRMEWHNQPCKGEKPPPRYNHAACYDEENNRLVVFGGRTAERKRLNDIYFLDLDSWTWFKPSTEGTAPTPREQAVATFWAGSMVLFGGHAIGGRTNDLFLLDLGAWQWSQPAFSGTAPSPRQACALCIGHGNLLFVHGGRNNFVLEDLHVMDFVSKNWTEIPCEGRVPPPRHSHRITVHRDQLYLLGGLDELGAQSVAMYRVALPAGQQDTYATSKPKWVEWDSELPYNKNRTATLWNGTISIYQLGSNTLGRVNDDDAEKGLDELRPKNAKRMRVQHTINTAGKMPRSFTQHSAHEARVLQYVQDFQRIFEELYPYRRPLYLTPRNECGVPKFVCTSLRPSQLVYTELYDLDGASQFVADFLSYEPLEDPLHPPDTLPSPMSALEWRAGDSFDMATVLASMLLGVGYNAFVVLGYAPGPVVQNDQRNTDLAATRTGAGAEEEEESGPCKFVHAWVMVLPGKREVTEAMFIEPSAGRKDVSYDLSDPTKWEPVFEDRGMRSRADGNADESETEGGGGLDDGEGVEAEVVPDIPPSWVPKLTIPRDAFDMRCPRHEIFARFGDCSRWDGMVERLVLYADEERTVVTEIRETFTRRRDKLRERRVYPQKDTTIEHFNRGSVFALKDILTVKNDRRGRKVIQYYTGRDDRLIYISATYAVDPLAPRPQPSALLEEYSSLLVAEKDCLQWVRDGEWEISEIIRTRTNQEQNITLETPYYDIVRIKAEESEEVREKALKALKDRLIERANIIQARLDEESAALAKRQQTFHRDRDQMSAAEEEDYERQTEESMFRIHILERRLRRHEEQALHKYYELDAKLRADGRLAALLN
Protein: Two-component response regulator CbrB (Q9HV73)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- histidine kinase
- RNA polymerase sigma-54 factor
- Catabolite repression control protein
- Sensory histidine kinase/phosphatase NtrB)
- histidine kinase
- MFS transporter
Sequence:
MAHILIVEDETIIRSALRRLLERNQYQVSEAGSVQEAQERYTIPSFDMVVSDLRLPGAPGTELIKLAEGIPVLIMTSYASLRSAVDSMKMGAVDYIAKPFDHDEMLQAVARILKDRQENRSAAPVSANGGKAGGERGASPAVADGEIGIIGSCAPMQELYSKIRKVAPTDSTVLIQGESGTGKELVARALHNLSKRAKAPLISVNCAAIPETLIESELFGHEKGAFTGASAGRAGLVEAADGGTLFLDEIGELPLEAQARLLRVLQEGEIRRVGSVQSQKVDVRLIAATHRDLKTLAKTGQFREDLYYRLHVISLKLPALRERGNDVMEIARAFLARQCTRMGRAPLSFAHDAEQAIRHYPWPGNVRELENAIERAVILSESQEIHADLLGIDIELDDLEDDFAADLGLGPAGAAASNHEPTEDLSLEDYFQHFVLEHQDHMTETELARKLGISRKCLWERRQRLGIPRRKSGASADS
Protein: Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1) (P46695)
Organism: Homo sapiens (Human)
Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Subcellular location: Membrane {ECO:0000269|PubMed:12356731}; Single-pass type II membrane protein {ECO:0000269|PubMed:12356731}.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Pituitary adenylate cyclase-activating polypeptide
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Sequence:
MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEPAAAPAGRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQQHPAAF
Protein: Uncharacterized protein (Q582U4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DM10 domain-containing protein
- EF-hand domain-containing family member C2
- Rib72 protein-like protein
- CFA20 domain-containing protein
- Cilia- and flagella-associated protein 45
- Enkurin domain-containing protein
- Enkurin domain-containing protein
Sequence:
MSYEIQPILKGTKRDPATRKYNRAAGKGPFGAFPPGYAPKQEKPSIPIEGPVAVQGVRFAYKGTVQRTGGTTTSLYKGRQQHESAVAFTTNGAGDSKPPKAGAFKRRLIPPTEFRRYYDRGDLPLSVAHGNRPTIDWKVDVERLDYHHYLPIFFDGIRETEEPYMFLARQGCLDLLKRGGPKILPTIPQLIIPIKTALNTRHPEIICATLRILQQLIVSGDLIGEALVPYYRQILPMFNLFKSRHKNRARGDAIDFGQRKRDDVGDLVIETLQLLEVHGGDDAYINIKYMVPTYESCIFS
Protein: TALPID3 protein (Q1G7G9)
Organism: Gallus gallus (Chicken)
Function: Required for ciliogenesis and sonic hedgehog/SHH signaling. Independently, involved in regulation of cell intracellular organization. Involved in regulation of cell polarity.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16702409, ECO:0000269|PubMed:19144723}.
Interaction partners:
- Centrosomal protein 120.
- Uncharacterized protein.
- Uncharacterized protein.
- OFD1 centriole and centriolar satellite protein.
- Intraflagellar transport 88.
- Zinc finger protein GLI2
- Transcriptional activator GLI3
- Sonic hedgehog protein
- Kinesin-like protein
Sequence:
MEAESGSSTSQDSLASLTAGDVLVRSTGVRGVKGAAGAGGRNSAAVSVTKLREALPSRQAAGVALSRGETPCEPPVPSSGASNGRVTGVTACSAAPGVWNAKGHPEHLLLVADPVEATSVPQMVYPKEAAVNPKEADRSLQPEYSRRPKDDVLISRYPTGQKEALRAVLKQKTRSAPVFKEVKVQLLGNASPERKESVGQDPILTHREADSATTIAAATAAAIATTAPLLKVQNDLQAKVNCVSTLLHKLQETDKQLQRVAEQQTNTKTQHEKPHCHERVSELEKQMNAFMLQRIHHLEKLQEHQMNIQSHFISSAVNMGGLQQTHMPSSGLLTKQSEKAEEQLLNNGISSSQKNFFPSSGLPTQGDGRHLEHILNPQAAPWGQMESSEKTMLTNDKMSWHSEIERPTALQTDSCPAYENSSQNCNSIEKTVKKADDLLQVLGQLRKEMHDMLQEASSWKSDMNDLIKSKPATIASDPPEYNHLVKPSVLQNVKAPNSILSDAKRVLREVQSRKKVLEENLEAVLRAKGGGAMSAFINALTTNRDALEKIRIRKAVDERIKAISAEIQAEMARNDMEQVKYDQKVPWIKRAQNIKAMKNSKEIKAKTQKIQGCSTKKPLSAAKSLRNHVEDNISKEGFRTYFSSESLQRNRKGTDEPMSGCAMVQNEEYLSQIYGKPIYQGHRSTLKKAPYLRFNSPSPKSKLQRPRVIEYVRGTKVKSAGTQTCSRAQKAVISSKKQHPLYALAQENQYFFSPNRDVPADCGPLEGHLIPMAVPLGQTQINDISVQPAGVVMCKPHPVTVTTSIPQVPPKPPTEVKKPNVAVIEMRSEKKDPPQLSVQVLPNVDIDSISGGSVSVNHVLPEPKPARCPADAVIQAPEDIQSEEEDVKFPGTNFTDVTDVVQDQEEERDEIPEFTEPLLEINGHFRVAEPTYNGPSFPPVASAPQQSCDVLDEWIERRETIENRLINWVEQEIMAKIISEMYPVQRETVPSVSTSEGEDSETVTSDIVEAAGGGGFQLFIDAGVPVDSEMISHLVNEVLSETIATMLGNRQAQEAVPATNLLPSTTAVMEPLVPTPLPTPQATPPQTPPSEKEMPPVQTPESSPSITELSGDVREQEKMKEAGSDIPAAVSRVGTPVITPISTPPEIITPSPPASEAAKMENPAPLNPWDDAELPLEEEKPSPLAEETFNPKAVEMSVANDEEPEALILPSWQSSPKPFQSLPCEPEAPSAAPTDSSEQSTQESSLTPTETETADRPISEGEVLFSCDQMLAAREGGLSFPNLTESLTSTLQDANEMDYDPPSEGQVVRRSHKGYHRDPVLALLAKLNQAPVAVQEGGYHLEDSDSSVGELSEGQRPRLTRAAERILMGHPVDIDHATARASEDRPYQGSRSPSPGQLTHPAEILGDADTSHGPMLVAELESQPISNPVLQAAQPSCRVASLPKGPSQEESQGDARVVRPRVVHVRRKSEEMQEEGEGVVPHFHSHVSAERMSVKLPSMNIDDQTQSLSSIHGDSDSSGADTF
Protein: Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase) (Q8VHT6)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11790780}.
Interaction partners:
- Lathosterol oxidase
- Sigma non-opioid intracellular receptor 1
Sequence:
MAAPRDAEIHKDVQNYYGNVLKTSADLQTNACVTPAKGVPEYIRKSLQNVHEEVISRYYGCGLVVPEHLENCRILDLGSGSGRDCYVLSQLVGQKGHITGIDMTKVQVEVAKAYLEYHTEKFGFQTPNVTFLHGQIEMLAEAGIQKESYDIVISNCVINLVPDKQKVLREVYQVLKYGGELYFSDVYASLEVSEDIKSHKVLWGECLGGALYWKDLAVIAKKIGFCPPRLVTANIITVGNKELERVLGDCRFVSATFRLFKLPKTEPAGRCQVVYNGGIMGHEKELIFDANFTFKEGEAVEVDEETAAILRNSRFAHDFLFTPVEASLLAPQTKVIIRDPFKLAEESDKMKPRCAPEGTGGCCGKRKSC
Protein: Longitudinals lacking protein, isoforms A/B/D/L (Q7KQZ4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular location: Nucleus {ECO:0000269|PubMed:12538650, ECO:0000269|PubMed:8050351}.
Interaction partners:
Sequence:
MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQDLSITRIAGLTWNEWNARLAMPLVTLREGVQPLVFPTDLSVDKQQGAAGLTAKDVNVSGRKTPTDGGGCKSEPRAASTPARTHSSSNHSSNGNGSGKPTKTSSGGKLNHLTEEEATALMLKAVAEKQAAAAAGTELSFGEDQASSGNGNSSDYPATLSGAVTFADVGGPAGLCHINILNSISAMNNLISGSTAAGVGITTGSGQSPSNSGHNNSAGGGSSVLGGADNGAGHPCPVCGRVYKLKSSLRNHQKWECGKEPQFQCPFCVYRAKQKMHIGRHMERMHKEKFKLEDVKNFAGSSGLDGDSSGATATAASVVAAAAALVSGVELHPHFS