wanglab/gogpt-training-data huggingface dataset:
Protein: Beta-2-microglobulin (P01887)
Organism: Mus musculus (Mouse)
Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Subcellular location: Secreted.
Interaction partners:
- Tapasin
- Antigen-presenting glycoprotein CD1d1
- IgG receptor FcRn large subunit p51
- H-2 class I histocompatibility antigen, K-B alpha chain
- H-2 class I histocompatibility antigen, D-B alpha chain
- Hereditary hemochromatosis protein homolog
- Protein disulfide-isomerase A3
- Calreticulin
- H-2 class I histocompatibility antigen, TLA
- H-2 class I histocompatibility antigen, D-37 alpha chain
Sequence:
MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM
Protein: Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (IRBP) (Interstitial retinol-binding protein) (P10745)
Organism: Homo sapiens (Human)
Function: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
Subcellular location: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Interaction partners:
- Clusterin-like protein 1
- Rhodopsin
- Zinc finger protein 239
- Short-wave-sensitive opsin 1
- S-arrestin
- Retinol-binding protein 1
- Cone-rod homeobox protein
- Arrestin-C
- Recoverin
- Retinol-binding protein 2
Sequence:
MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL
Protein: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (A0A8I6AQA1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAEGHDAALSVAEWLRALHLEQYTALFEQHGLVWATECQGLSDASLVDMGMNLPGHRRRILAGLHRAHAPPPVPVPRPAPRPVPMKRHIFRSPPVPVTPPEPPPTAGEDQGLPAAPPIPPRRSCLPPACFTPPSTAPPDPVLPPLPAKRHSVEPSLPPVPPRTGPPYPQTSLLSKEELLLPSVSPWSQPEPTETPSTLLPAFPQGPLQPPSPPPCPPVIPPKPLRLLPEFDDSDYDDVPEEGPGAPASVMTKEEPLPSRVPRAVRVASLLSEGEELSGDDAEDEDDHAYEGIPNGGWPTIGLNPPLSSLIPDLPLHPMDELPGGSTPTTPVIKAGWLDKNPPQGSYIYQKRWVRLDADHLRYFDSNKDAYSKRFVPVACICRVAAIGDQKFEVITNSRTFAFRAESDVERNEWMQALQQAVVEHRAHIRLSSASVLGVRGGTEQPDHAGSLELRGFKNKLYVAVAGDKVQLYKNLEEFHLGIGITFIDMNVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAAQPDWASINLCIVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIQLFLQLGNGPGNHFWAANVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGVNCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPRLDSVKPSEKHYSITLPTVSHSGFLYKTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGSELRAVFPEGPWEEPLQLRRLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMAWLGAIQKAAASLGDTLSEQQLGDSDIPVIVYRCIDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFGPTLFQTDGQDYKAGKVVEDLISHYVVVFSVDEEELRKQREEVTAIVKMRVAGTASGTQHAGDFICTVYLEEKKVETEQHVKIPASMTAEELTLEILDRRNVSIREKDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGMDSHLVVKKYPSMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLSVQHDGLVWPSEPSRVSRAVPEVRMGSVSLIPLRGSENEMRRSVAAFTADPLSLLRHV
Protein: F-box and leucine-rich protein 22 (EC 3.4.19.12) (F-box and leucine-rich repeat protein 22) (Q5EAS7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MHLIELDQECLLHLFSYLDKDSRRSLSLTCVRLRQVFLDPQLWTLLHFWSPCELRRDNFVVGSSLRYLAVCWHSSRVKVCNIEHWMKTTFQKDLCSKHESFVSDFLEHVCNMCPNLISLTLSGCGHIMDNNVIKVLQSCRRLRSLSLENCARITDSVLKAAVEHGHNLTEVRVDFCRNVTQAGLQELKNKKPEVLLSALHSADMIPDCKPEEKTHIKRALQKFLIFS
Protein: Ubiquitin-binding protein CUE5 (Coupling of ubiquitin conjugation to ER degradation protein 5) (Q08412)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 adapter and thus mediating autophagic clearance of ubiquitin conjugates under starvation conditions. The CUE5-dependent selective autophagy pathway plays an important role in clearance of cytotoxic protein aggregates. Not required for cytoplasmic to vacuole pathway (cvt), mitophagy, pexophagy, or ribophagy.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Note=Localizes to cytoplasm in a punctate pattern.
Interaction partners:
- Autophagy-related protein 8
- Donuts protein 1
- Protein YSC84
- LAS seventeen-binding protein 3
- Polyubiquitin
- Ubiquitin domain-containing protein DSK2
- 26S proteasome regulatory subunit RPN10
- Autophagy-related protein 40
- E3 ubiquitin-protein ligase RSP5
- Autophagy-related protein 36
Sequence:
MEEKEGIKDSSLLEKSNVPESINEDISKTTDVDLNSDGKKDNDTSAKDGTPKVEEKVNKSSGIDEDEVVTPAEDAKEEEEEHPPLPARRKSEEEPSKENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDPESGKDIELPTQPVRKNPEAPARRRQTQLEQDELLARQLDEQFNSSHSRRRNRDRATRSMHEQRRRRHNPNEREQHHEDSEEEDSWSQFVEKDLPELTDRAGRSLQDTANKVSNWISDAYRRNFASGNEQNDNQHGHQDQQEWEPEIVDLSQGGKNSRPQQPERRRFNSFGVQVGDDSLESHGITLHNEDGFEDDEDVPPQLPTRTKSGESTGKVVAETTYIDTPDTETKKKWQPLPPEPLDTTPTKVNAVSRNKKNPDEDEFLINSDDEM
Protein: Vacuolar iron transporter 1 (EgVIT1) (P0DO17)
Organism: Eucalyptus grandis (Flooded gum)
Function: Vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage. Can transport cobalt ions from the cytosol to the vacuole.
Subcellular location: Vacuole membrane {ECO:0000305|PubMed:30742036}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MADGANDGGNPGAEEQQRLLDQHKEAHFTAGEIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPDPKRALQSAFTIAIAYVLGGLVPLIPYMFIPVARKAVVASVILTLMALLIFGYAKGYFTDNKPFKSALQTALIGAIASAAAFGMAKAVQS
Protein: Opacity protein opA65 (Q04885)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
Interaction partners:
Sequence:
ASKGNGRGPYVQADLAYAAERITHDYPEPTGAKKAQLSTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWKESNSSIKKVTEDIKDNYKETKTEHQENGTFHAVSSLGLSTIYDFQISDKIKPYIGVRVGYGHVRHQVRSVGQETITVTPKPKNGTQGGPVKSTSPIPAYHENRSSRRLGFGAMAGVGIDVAPGLTLDAGYRYHYWGRLENTRFKTHEASLGVRYRF
Protein: Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT) (P35900)
Organism: Homo sapiens (Human)
Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:1696264}.
Interaction partners:
- Homeobox protein CDX-2
- Synaptophysin
- Cell adhesion molecule CEACAM5
- Homeobox protein Nkx-2.1
- Prolactin-inducible protein
- Napsin-A
- Mucin-2
- Paired box protein Pax-8
- Chromogranin-A
- Keratin, type I cytoskeletal 9
Sequence:
MDFSRRSFHRSLSSSLQAPVVSTVGMQRLGTTPSVYGGAGGRGIRISNSRHTVNYGSDLTGGGDLFVGNEKMAMQNLNDRLASYLEKVRTLEQSNSKLEVQIKQWYETNAPRAGRDYSAYYRQIEELRSQIKDAQLQNARCVLQIDNAKLAAEDFRLKYETERGIRLTVEADLQGLNKVFDDLTLHKTDLEIQIEELNKDLALLKKEHQEEVDGLHKHLGNTVNVEVDAAPGLNLGVIMNEMRQKYEVMAQKNLQEAKEQFERQTAVLQQQVTVNTEELKGTEVQLTELRRTSQSLEIELQSHLSMKESLEHTLEETKARYSSQLANLQSLLSSLEAQLMQIRSNMERQNNEYHILLDIKTRLEQEIATYRRLLEGEDVKTTEYQLSTLEERDIKKTRKIKTVVQEVVDGKVVSSEVKEVEENI
Protein: Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) (Q9P1Z0)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16354688}. Chromosome {ECO:0000269|PubMed:16354688}. Note=Localizes to chromocenters. {ECO:0000269|PubMed:16354688}.
Interaction partners:
- Zinc finger and BTB domain-containing protein 17
Sequence:
MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALLTSAPLPLPPATGGAAPNPATTTAASSSSSSSSSSSSSSSSASSSSSSSSSSPPPASPPASSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDAWVPPTPAPMATSQPEEDSFGPGPRPAGEWEGDRAEAQAPDLQCSLPRRPLPCPQCGKSFIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPGGPAGVDASALPPPVGFRGGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTLKLYRLLPMRAAKRPYKTYSQGAPEAPLSPTLNTPAPVAMPASPPPGPPPAPEPGPPPSVITFAHPAPSVIVHGGSSSGGGGSGTASTGGSQAASVITYTAPPRPPKKREYPPPPPEPAATPTSPATAVSPATAAGPAMATTTEEAKGRNPRAGRTLTYTAKPVGGIGGGGGPPTGAGRGPSQLQAPPPLCQITVRIGEEAIVKRRISETDLRPGELSGEEMEESEEDEEEEDEEEEEEDEEESKAGGEDQLWRPYYSYKPKRKAGAAGGASVGGSGLPRGRRPPRWRQKLERRSWEETPAAESPAGRARTERRHRCGDCAQTFTTLRKLRKHQEAHGGGSHSSRAGRRPSTRFTCPHCAKVCKTAAALSRHGQRHAAERPGGTPTPVIAYSKGSAGTRPGDVKEEAPQEMQVSSSSGEAGGGSTAAEEASETASLQDPIISGGEEPPVVASGGSYVYPPVQEFPLALIGGGREPGGGRGKSGSEGPVGAGEGDRMEGIGAAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGAGALPFLPGVFGYAVNPQAAPPAPPTPPPPTLPPPIPPKGEGERAGVERTQKGDVG
Protein: Outer spore wall protein 1 (Q08692)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in a late step of spore wall assembly.
Subcellular location: Spore wall {ECO:0000269|PubMed:15590821}. Note=Predominantly at sites of spore-spore contact.
Interaction partners:
- Protein MUM3
- Putative uncharacterized protein YDR250C
- Sporulation-specific protein 2
- Subtilase-type proteinase RRT12
- Outer spore wall protein 2
- Lipid droplet organization protein LDO16
- Spore wall maturation protein DIT1
- Putative uncharacterized protein YJR037W
- Outer spore wall protein 4
Sequence:
MRAPPSPRKSKSGHFFYLYFRLCQLFSGRKLKRRWHVHKLHIHQYNTRWNLSPLSEIHIEDMINEPSGLCPGSSKKKPLLIARFPKGCQESPRVYVLQRNNLSRLKLSKRKYALRFYHNEIFGNNLKRKDGSIHKVEHQQCAETVRKIKKVTANHADVKIIFHDKNTIRSDKLGGRSNKMQTRPSVLEEDVEEEVSSVYIRFCDDHSLRVKDYHSLHRHSKKSSKEKRNNQEIGKSKLLGKLFEEETSRQNKGVEKKLDTIVIQKFQNYPIVSFSRVI
Protein: Fork head protein homolog 2 (P41813)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval. Involved in HMRa silencing. FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth. Acts as a rate-limiting replication origin activator via its interactin with the origin recognition complex (ORC).
Subcellular location: Nucleus {ECO:0000269|PubMed:22932476}. Cytoplasm, cytosol {ECO:0000269|PubMed:12702877}. Note=Relocalizes to the cytosol in response to hypoxia. {ECO:0000269|PubMed:12702877}.
Interaction partners:
- Nuclear division defective protein 1
- Pheromone receptor transcription factor
- Metallothionein expression activator
- G2/mitotic-specific cyclin-2
- Transcriptional factor SWI5
- Regulatory protein SWI6
- Fork head protein homolog 1
- Regulatory protein SWI4
- Cyclin-dependent kinase 1
- Homeobox protein YOX1
Sequence:
MSSSNFNEMNELNMTQTNYGSTKYTAQHHQGVINAIISSLTAPDQPTTVSLQYSNDKNMATEIQAYAKLSGPNWTYYVKDLEVSIGRNTDPLNSALQENSDGVKNSYRVNIDLGPAKVVSRKHAIIKYNMNIGGWELHILGRNGAKVNFQRTHNGPNNPPIRLSSGTLLDIGGTQMMFILPDSDPVVAPICIEHLMPNLINMFGLEGNNNPLLRDIIKQSNYAKQRQLTSNQQIKGFKLYGSGGNAPFGSGANLGPSEQGIFNNNNNSKNKNGYFTSINPNYTASTTTSNTINPQAASPQGPPNTIIAANFVDSYKSSNAYPQALDFTSDLSHDENRNVKPPHSYATMITQAILSSPEGVISLADIYKYISSNYAYYRFAKSGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWRISESYQQEFLNKWNTGKVGKIRRGSSVARQLQLHMAKFNSLPMEMDYRLSLNMAQPPKRQLQSHNVLEPSNNNIIEGFVQHVPSKGNLPASQQSQPPVSHQNQSQQPPPQEQRQEIQFTFADTQNRNIALARPIKTPQLQAPNSNANLNQNNMKEYKESLHPPAISISQMNRQSPNNALVSFTNACANSKIINNISDSADKSTNNNGGTKMNLPAISTSSLDENGNLEPTTTTSSGNSNSVPQTGTTTSSLAANSLRLSQPYDTLLRSPTKAFHITAMEAYTPERGSANRARSPLHSNSNNTNNNGANNSNLQTSGMENKQTGLVLDSNVLKSMESNNDNRRLTPSTSKSQNVKSSPGVWNLLQFSSTNNTPAADSGGNKRGFSINPDIKAKENENATSEKDSDSNSNDLETKDINSSPLKNQGGSTANAKELILDTDGAKISIINN
Protein: T calcium channel alpha1G subunit +34+35 splice variant (Q9JKS7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTDRQLFDTISLLIQGSLEGELKLMDELAGPGGQPSAFPSAPSPGDSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDTHTLLLSALESNMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQ
Protein: E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) (Q76N89)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14684739}.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Translocon-associated protein subunit delta
- NEDD4 family-interacting protein 1
- Superoxide dismutase
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-B
- Ubiquitin-conjugating enzyme E2 K
Sequence:
MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE
Protein: Growth hormone variant (GH-V) (Growth hormone 2) (Placenta-specific growth hormone) (P01242)
Organism: Homo sapiens (Human)
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Protein: Raf kinase inhibitor (Q7KQK1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Uncharacterized protein
- Ribosome-interacting GTPase 1, putative
- DNA polymerase II subunit 2
- Citrate/oxoglutarate carrier protein, putative
- Peptidyl-prolyl cis-trans isomerase
- Citrate synthase
- P1/s1 nuclease, putative
- Syntaxin, Qa-SNARE family
- Kelch domain-containing protein, putative
- ADP/ATP translocase
Sequence:
MTIPTISELKKDRIIPHVFPNDKIDLNVDLFISFKAGKEVNHGNVLDIAGTGSVPRNIKFSEEPPDGYCFVLFMVDPDYPSRLRPDGKEYIHWVVSGIKTKELIKGTQKNCVTILPYVGPSIKKGTGLHRISFIISLIKEEDKDNITGLPHYKGEKYITRVKFNNYESVHNIAQINNMKIVGYNWCQIEG
Protein: At5g05790 (Duplicated homeodomain-like superfamily protein) (MYB transcription factor) (Similarity to I-box binding factor) (Q9FFJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370
- Myb family transcription factor PHL5
- Zinc finger CCCH domain-containing protein 20
Sequence:
METLHPLLSHVPTSDHRFVVQEMMCLQSSSWTKEENKKFERALAVYADDTPDRWFKVAAMIPGKTISDVMRQYSKLEEDLFDIEAGLVPIPGYRSVTPCGFDQVVSPRDFDAYRKLPNGARGFDQDRRKGVPWTEEEHRRFLLGLLKYGKGDWRNISRNFVGSKTPTQVASHAQKYYQRQLSGAKDKRRPSIHDITTVNLLNANLSRPSSDHGCLVSKQAEPKLGFTDRDNAEEGVMFLGQNLSSVFSSYDPAIKFSGANVYGEGGYCISQDLETRK
Protein: Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) (Q16719)
Organism: Homo sapiens (Human)
Function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Subcellular location: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}.
Interaction partners:
- Kynurenine 3-monooxygenase
- Tryptophan 2,3-dioxygenase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Kynurenine formamidase
- Kynurenine--oxoglutarate transaminase 1
- Indoleamine 2,3-dioxygenase 1
- Kynurenine--oxoglutarate transaminase 3
- Indoleamine 2,3-dioxygenase 2
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Catalase
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
Protein: ABC transporter G family member 2 (ABC transporter ABCG.2) (AtABCG2) (White-brown complex homolog protein 2) (AtWBC2) (Q9ZUT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase 5
- Cytochrome P450 86B1
- Cytochrome P450 86A1
- Fatty alcohol:caffeoyl-CoA acyltransferase
- At3g02940
Sequence:
MSGLLGKSSPAKRVDGNNDLPMYYVNPMSVEPQGRPSDTTRVSVTFAEHLMNVEDARNDESASSRALGIASPINSAASSFNSWASAPASSISSSPFVLSFTDLTYSVKIQKKFNPLACCRRSGNDSSVNTKILLNGISGEAREGEMMAVLGASGSGKSTLIDALANRIAKDSLRGSITLNGEVLESSMQKVISAYVMQDDLLFPMLTVEETLMFSAEFRLPRSLSKKKKKARVQALIDQLGLRSAAKTVIGDEGHRGVSGGERRRVSIGNDIIHDPIILFLDEPTSGLDSTSAYMVIKVLQRIAQSGSIVIMSIHQPSYRIMGLLDQLIFLSKGNTVYSGSPTHLPQFFSEFKHPIPENENKTEFALDLIRELEYSTEGTKPLVEFHKQWRAKQAPSYNNNNKRNTNVSSLKEAITASISRGKLVSGATNNNSSNLTPSFQTFANPFWIEMIVIGKRAILNSRRQPELLGMRLGAVMVTGIILATMFTNLDNSPKGAQERLGFFAFAMSTTFYTCAEAIPVFLQERYIFMRETAYNAYRRSSYVLSQSIISIPALIVLSASFAATTFWAVGLDGGANGFFFFYFTILASFWAGSSFVTFLSGVIPNVMLGFTVVVAILAYFLLFSGFFISRDRIPVYWLWFHYISLVKYPYEGVLQNEFQNPTRCFARGVQLFDNSPLGEFPNDVKVNLLKSMSGVLGTNVTAETCVTTGIDILKQQGITDISKWNCLWITVAWGFFFRVLFYFTLLIGSKNKRK
Protein: Kinesin-like protein KIP3 (P53086)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23001566}. Note=Colocalizes with beta-tubulin TUB2 at the plus ends of growing microtubules and along the microtubule lattice. {ECO:0000269|PubMed:23001566}.
Interaction partners:
- Dynein heavy chain, cytoplasmic
- Kinesin-like protein KIP2
- Kinesin-like protein KIP1
- Spindle pole body-associated protein VIK1
- Protein BIM1
- Anaphase spindle elongation protein
- Nuclear migration protein NUM1
- Spindle pole body-associated protein CIK1
- Karyogamy protein KAR9
- Protein STU2
Sequence:
MNVPETRQSSIVVAIRVRPFTSMEKTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGSTRSKRNSLLRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVSDQVLNSMRARATKATASSINNSNATNKFSSQRRRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGTPSQPGIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIREDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDLTSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYLKMITEQKRQIEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQQTYAGVETYQVAKTLKSLILCKRRFLQMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMKFDETDTLSSVIHQVHSIDLNKLREMEDWDETYDLVYLESCLNQISELQRNEILVNSSIMTEKLMSDPGLNSRFKFLSKWLMNRTPNIESIIQDLVHIDEEFESFARTFIANPDSNFTNTNINIINTTAADLAVPAETLQRQNFSQKKVKWTSPDLSPSPMIEPQPELEPELHQDQDAIASEVDVSMQDTTFNEQGPSTPSAPTTAVPRRKMRSSLLTHQSLLATARK
Protein: Homeobox protein Hox-D10 (Homeobox protein Hox-4.5) (Homeobox protein Hox-5.3) (P28359)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-D9
- Homeobox protein Hox-A5
- Homeobox protein Hox-A2
- Homeobox protein Hox-A10
- Homeobox protein Hox-D3
- Rho-related GTP-binding protein RhoC
Sequence:
MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMGTYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCSFTANIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYATGKTQEYNNSPEGSSTVMLQLNPRGAAKPQLSAAQLQMEKKMNESASGQEPTKVSQVESPEAKGGLPEDRSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELTANLTFS