wanglab/gogpt-training-data huggingface dataset:
Protein: RecA protein (EC 3.1.-.-) (Q6MQS4)
Organism: Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)
Interaction partners:
- DNA polymerase I
- LexA repressor
- DNA polymerase Y family protein
- Regulatory protein RecX
- Error-prone DNA polymerase
- ATP-dependent DNA helicase RecQ
- ATP-dependent DNA helicase RecQ
- DNA repair protein RecN
- DNA 3'-5' helicase
- DNA 3'-5' helicase
Sequence:
MQIASLLTHNLHSNLCVNGELQMSTLALPELANIPFVSAEQLQPPPGLPTGVNVLDDFLLWKGVPQGDLSLLQGAPGTGATSLWIRIVQNVHSQNKWAAWINGDAQLFPAHLSSYKINLKKLLVVKEPKENEQLFWLLQELITSSLFEVIGCNLKEMFLKNHQLQKLKRLCRLHKVALVFVNQKASKFVNPLFSLMIHFQRDFITIQRALHRPTPFNLAGSMIHANFMHQFKNTARKLLS
Protein: Histone acetyltransferase (EC 2.3.1.48) (Q7ZW29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361211}.
Interaction partners:
- Histone acetyltransferase KAT2A
- Transformation/transcription domain-associated protein
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT2B
Sequence:
MPRRKGHKSPFQLILNKPINTERTAGSSSDGTADSDDSGDHEKTDSSHGEANQRNNTRMTRASLRLSQSSQDAPPDIKQAVERDESPPRTPTGNAPSSESDIDISSPNASHDESVTKDQKDSGSDPSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFAISGCPLYHNLSADECKVKAIEREKQDEERSQGQNEENRHATRHQAPTPRQVRYKEKVIEMRKRRDSGLSKDQKEKYMEHRQTHGTTREPLLENITSDYDLELFRKAQARASEDLEKLRLQGQITEGSNMIKTIFFGRYELETWYHSPYPEEYARLGRLYVCEFCLKYMKSQTILRRHMAKCVWKHPPGDEVYRKGATSVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLVGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYMYNFKGKEISIKEISQETAVNPVDIVSTLQSLQMLKYWKGKHLVLKRQDLIDDWKAKETKRGNSKTIDPGSLKWTPPKGT
Protein: tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (A0A590UJ73)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR017250}.
Interaction partners:
Sequence:
MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLMPEEARLLAEIGAVTLVSAPRPDSRHHSLALTSFKRQQEESFQEQSALAAEARETRRQELLEKITEGQAAKKQKLEQASGASSSQEAGSSQAAKEDETSDGQASGEQEEAGPSNGVAPLPRSALLVQLATARPRPVKARPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDFLVYPGDPLRFHAHYIAQCWAPEDTIPLQDLVAAGRLGTSVRKTLLLCSPQPDGKVVYTSLQWASLQ
Protein: FI21747p1 (Q8IMT2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKVPKIPDWVSSLSLNQAVHSVLEDGVQITSVIPSVHLIQFRNCTVLLPIQVKVQLRDFTMKKLFFLLKAQHGTDIQAMVMNQLKMFQREHQVYHNVLPKLEEIYREVGKKVSFGPRAFRLDYSIGVQYVLLEDLKAKSYKNVERQAGFNKLCLKQVLKKLAQFHAASAVCVEKHGAFSNLLVNGVYTKANESVLQELNDPEIFLSQLRRWRLGDHFHKRLVEKEKDLVDGLLKLHSPDSNEFNVLNHSDCWVNNVMFKFDDSGHVEDTALLDYQLVKYGSPAIDLYYTILSSAEKDIKLAQFDNMVQYYFYHLLDNLKALNFGGSLPQLQHIRDALNKNGLAAYVVVTRALPITMMNQFEDEVNERYASKMKCAMFTSRKYIQAIKDILPWMEERSLLN
Protein: Pre-mRNA-splicing factor cwf15 (Complexed with cdc5 protein 15) (P78794)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-processing protein 45
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor cwf7
- Pre-mRNA-splicing factor prp5
Sequence:
MTTAHRPQFDPARGHSEMAPTRITSSRALPAHLKLKYRQESQGTEEEVRKQDLREALLRAEAAHFATQEHGASSEEVSQNSKLIEGFTSPSTDDKPNNDVEVDYQELLRQTLEADEDASDSDDSVDSSNKNSEVSIKRRKTESNSQESVDSSNSESSDEESDSEDETQQLLRELENIKQERKREQMLQEEKNRALEQEKREREIAFGNELLNKASSGSFQVKRRWDEDVVFRNTHKGVDDTPRPGFVNDMLRSEFHKKFLARFVD
Protein: Putative GTPase-activating protein C1620.12c (O94419)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSKSVNASLSSAINSVTLVKQENLKENLQNGSAVSVGSSESSNHSMKEISLDYSSPSLQQTEEQDRELNFIDSSMLRPTPPQESDNRLAVEKPNIQPLQGHSPVPSFMSTASTNISSSKINNNQTEFEQLRDSYKSHGDLNSAINDSRIQSIIFELNQQCEKESIPVSNIDWLQWASVPLFAYDLPPDPSNPNATSSSPPPLTPILELIKQNNFCIPSPCRKLVWQSLVSAERNELLTLYATLSTTNNSLDSSIRKIIRMQSFRGPLEPFKYSSTTRHKVSTESIFHVLHAFTLFDTTVEYNIEPLLWLTCAFLSYMAQGNAFRSLVCFIQRGGIREFFISQSSSLDESLFALVWGCLGDLAPSVAISLQRIKVSSLCILYPSLACCFADSLQLPEALRLMDLIAIYGLEMFVRLLVAIFLKDRDKIVNMVSHEQWVKYLRSDVLASYRQPLVQKYTFYTRTPVDLNAWVEDSLALNIDTTQFPSYLSYHETSVSHNTYRQNNLEELKNQNDYLTSQITNLEEGMVMLNKENTKLSEALSNHRVTRSEMEEATEILKNNSADLKAQLEKQPQELENRLLQEISILKQRNQKFLKNNATSIQQIQYLDEELGKTLKQLNDLKEKHAQLQTKWKSVSEMFRN
Protein: Meiotically up-regulated gene 79 protein (Q92349)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Appears to have a role in sporulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Sporulation-specific protein 15
Sequence:
MDFRITEGSSPTSLSVSEKIAKLESCNDSRITCRPVRESKPTYTSGQKHSALLSKLKRSKVTTDFCKLEESKGIICQENLHTEGAKSKTENISGEDKSSQRRTRLKQIQEFISHRRSFLNSNANSVESEKILAENNHMFNVKSKLSNKESFIKTRRPRTNGELSDLSLQPKRIFSEPVNSHPSQSMFGNGVRASSGSYSLKRDLKDYEEELPSSKKRQRTPPPIVVTNFPQEIFPSKKISLSAKRRIQGKYSGENVRARIELARERNRKRDYVSNLSKGHTTNALEENPFNLGPNYRASTRKCNRIKEAINLFAAKNGSMEVPPKVSVGDSVLTTSQKFLQVIREKTALLMNQDSNSVQPQALAAAESPTTKAPTTKAPTSEAPPKGHVKQLAKQLGNIYMPQSINNVEPTSHSSISKVVNPSEKVISKIERACLAGNGNVHPSIKMEKNLELNPHPRTLNATEHKINSRIQVSKLNTKNELANADPKMYLLENLSDRLYFCKLAKLLLRKYPLDIAEHQFALVYSRFQRIPLKQISCLKQSLVAYYSVLSEVGITNEIMLRENRFSSPKTPEGLVSISKLLLDDREHLSHDERSYIQQLQSQIKSQSVHHENAAEEIRKMRNLRNSRINSQQVGEKVFVNPDVKTMDIQETFLQDYEDETFANEGLSASKFKEEFLLISDSKSDLNSEEIATPNSLEFKNNPRIKVPRSLLTILNLHDRSQLKLFEVCHNSEFKDPINLSNCLRNLLEKQLLSYNFTDWFASLGSEYENVYVKFISHYDFSSLNVYASFQKLCCDLYYGSDDYIHSPILQVFASCWLKQNSNYGFLNEDIIVKIVLILIDLHKSTYSKKLNSYVVPMETFVKYALEKLRPLISPDSVCILSKEDKKHWLKYKKNRSTFAKLLFSTWSNLPSDIGFILECMLKEYYDTFLKSPFAVPNAVQAQLHNQVRGDLTPKRNRSSLISELMKSSKLLKQESSGNKNSTSLESDAFKESSFVLNEENGGIYAGKEIDLPEPSVIDGRPHFSVFNYTHHMQEEKTHNRLPWHRRGMISYKKMVLSKNNRWVAGYWKKKYCIVDSGKLIFYKSDHLDPNACSNVSPIHREFGLQSCLASPNLPPSINSNRNNVFYLNIPGNECYLFEAPSVLAMNEWIHSLNFNAAMITCPPLPENITNTEYGWGYILTRAEKKAYYTAADGTKTFVGDLAQLTRWSPMDIQGLQDIPRPLRDKVHILRDCVPSLLETCLLFQSLPEKMEKCFAAGSKNYLKAMDNWNRKMKFLYERSMMYKEYQRVLECEYEYRKSHDFYPTLSPVRYPYDFKGL
Protein: Dynactin subunit 1 (Q23542)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSFEIGTRVKTSSGNGRVVFCGQTQFAEGDWVGVILDTATGKNNGTVQNVQYFECEPNFGVFVKSSAVELEDASKRSGLKAPAASAIRKDSSVMSRSAGSKASPGSSPGMSPAASSEKLTGRQTGMGPRSMSKLADPNESRMVREFSNLSQSSVASSRASASASKPRPQFTAPDPRRQSLAPPKKASTTTAPVSKPSLSKPRQSLAPSKPAEVTPQKPVPAAQASEAGDPPNELPLPTMTESGTELPKESVLSRAKKIDDTGPAAPMSPLSTTAAARPRTTSVSSSAQESSTEIEYLRNQVKELTEKLEAARVKRKEDHTKVMELDRVSFELRSSEEVRSRLIQKITELEKQIGDERIAKEQLQAWQDENKVLLSDHQDTMEMATIEKELAEERADSLQNDVLTLTEKLESMETELEILKEEMANGGGAAQVGNSVQMKQIEIQNDKLKDALIKLRDLNAQATLDRQKAVDEAERLKTENSELIRVAENLKRQTEIAESKIAGFQEQIDAAMGAEAMVTQLTDKNFNMEERIMQLEETIEDMEEARDLDEQLAEVQKQQVKDLMKEIEQLKIHIHELNGRIRDEQKHAVDLSQTILKFRERMANLNSQIQDQKDQVLSLEEQLHGHISVDNDRASMVNQLQISANRNFAEDVERQVNAIEVEFARRQAGYLKAFLPDNFSRVGGENDSILLVVMLPRLAAKTKLFASLAAQCFPQVPGGMRREHVTKSHKGEQWAHVARVNYLANSINAALGKLESAIGETTVEVLIKLTETYGEMSTHEKTVDQYLELLKKSRFDENTSLDSFVRPLVYFQNMFSLHIGGDGFNAAHWVSEICASLSAGLAYCRVNTQRISYFLQESITAGEVYNMLQTLNDEFAACESVILKAYRLLPGNVSGSEQKILKLESEFTEDLLNSVVQLDKMVSILQEVCANGALSFGGISETEGFDEKRVKEMINAVLGKQDGYIAIDKTFDPIRALIKSLRDSLEKVNSTLESAKMEHSAPEKKSFPPLLDRAHHRKQAAQEAEGLRWQMEKKDNEMLELRKQMKARIEDVSNYKLRLDMAESRLNSTDKAEGDKVKHLEEKINQMVADHRRKQIEYDESMDALQREMKEVESDNLELKQRANKISKEALWKNIQSMETRSSGSPSVPMSTSIDEGGASRGEVVFLENQLNKQTNARKRAELEVRKLKGELAQAGSKRFSAVPGLISGPITLESQTRQDLLLKLIDNLHDESLRLRREEVNHQAYVPSNPKISTEKMVEEMEIFNVKREQFFDKLNSVNRRLRRVWFDAWGEEYPFEIAAKSRPIVAVPEPKKFEEISAKWGIVW
Protein: Actin-like protein 7A (Actin-like-7-alpha) (Q9Y615)
Organism: Homo sapiens (Human)
Function: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32923619, ECO:0000269|PubMed:34727571}. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail. {ECO:0000250|UniProtKB:Q9QY84}.
Interaction partners:
- Alpha-catulin
- Testin
- Protein enabled homolog
- Dynactin subunit 2
- Actin-related protein 10
Sequence:
MWAPPAAIMGDGPTKKVGNQAPLQTQALQTASLRDGPAKRAVWVRHTSSEPQEPTESKAAKERPKQEVTKAVVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETAKTGDNRKETFVGQELNNTNVHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFEAFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLLGLLNSAGNEFTQDQMGIVEDIKKKCCFVALDPIEEKKVPLSEHTIRYVLPDGKEIQLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVNVLPERDSAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF
Protein: Augmin complex subunit dgt6 (Dim gamma-tubulin 6) (Q9VAP2)
Organism: Drosophila melanogaster (Fruit fly)
Function: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17412918, ECO:0000269|PubMed:19836241}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23785300}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24829288}. Chromosome, centromere {ECO:0000269|PubMed:24829288}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19836241}. Note=During mitosis, localizes at aster centers in prophase cells (PubMed:19836241). In prometaphase and metaphase, associates with the entire spindle (PubMed:19836241). During early anaphase, primarily detected on the kinetochore fibers undergoing anaphase shortening (PubMed:19836241). In late anaphase and telophase, becomes enriched at the central spindle but is excluded from its middle region (PubMed:19836241). In interphase cells, displays a uniform distribution (PubMed:19836241). Enriched at spindle poles during meiosis in oocytes (PubMed:23785300). During male meiosis, localizes to kinetochores in a microtubule-independent manner but does not concentrate on spindle microtubules (PubMed:24829288). {ECO:0000269|PubMed:19836241, ECO:0000269|PubMed:23785300}.
Interaction partners:
- Augmin complex subunit dgt3
- Augmin complex subunit dgt2
- Augmin complex subunit msd5
- Augmin complex subunit msd1
- Augmin complex subunit dgt5
- Augmin complex subunit wac
- RNA-binding protein 42
- Augmin complex subunit dgt4
- Grip71
- Kinesin-like protein Klp61F
Sequence:
MDRTIIAPWKAEEKEQSEKLHRKLQGLALVHPLPDELRKLIAWDMFLKPNQVAFVHVMHYLFRLLDPAEFKRRFFWPITDKKSEANFRSSTVEYLKHLNEKHQLHWANIKSYLVVMPGGMRFINFLLEFVGFVIQELIKQREKSLGLEAGTPNVSAKVMARQNAVMKEYASSYVVNLEENTALLRDKTQKIRRLMADLSADMGVPEEQLADDGFLDEFEATAALGVERVITQPTERKFDLEASLCGLKEAIDLFQVKQAENNQSKEAVEKALRGMRVLFDCDAVTEGDFYDPLGASKMDALLNGFNRISGTIAEQLDANDHYNESNAFVTTDLQALRVELSQSEVQLNNLLKKLNEPSKKDKGSANASGSARVQTLQPATPRFESVISSKFVSTPPIRIDMGGGGGRNAPVRLALQDDFNGKQFDALSNSLLAPAPPRSARKLKALDQSTGIDLNGTLNRSKINDPMQMLRTIHKNTSKVKAAPQANLSSLGSKWKQMQASFGFDEAPVPGAAVISPQTSPTDPSDPFTPLSGSECTRIERIPRTSENNTSLIAKSAAVIKVLEVSRNVLNLSTSPSGRLDALVPHTESHQQDVAPRLQLNDRTINDSLQLDPDFNIENDKNAFNVSHKFDFDQIGGEDDLQNISDSVLKDIIF
Protein: Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) (Q9Y2T7)
Organism: Homo sapiens (Human)
Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16479255}. Nucleus {ECO:0000269|PubMed:16479255}.
Interaction partners:
- Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
- Homeobox protein NOBOX
- Factor in the germline alpha
- LIM/homeobox protein Lhx8
Sequence:
MSEVEAAAGATAVPAATVPATAAGVVAVVVPVPAGEPQKGGGAGGGGGAASGPAAGTPSAPGSRTPGNPATAVSGTPAPPARSQADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEATNVTGPGGVPVKGSRYAPNRRKSRRFIPRPPSVAPPPMVAEIPSAGTGPGSKGERAEDSGQRPRRWCPPPFFYRRRFVRGPRPPNQQQPIEGTDRVEPKETAPLEGHQQQGDERVPPPRFRPRYRRPFRPRPRQQPTTEGGDGETKPSQGPADGSRPEPQRPRNRPYFQRRRQQAPGPQQAPGPRQPAAPETSAPVNSGDPTTTILE
Protein: Conophan gld-V (Gamma-hydroxyconophan gld-V*) (P84700)
Organism: Conus gladiator (Gladiator cone)
Function: May act as a neurotoxin.
Subcellular location: Secreted {ECO:0000269|PubMed:15853325}.
Interaction partners:
Sequence:
APANSVWS
Protein: Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) (O00168)
Organism: Homo sapiens (Human)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha-2
- cAMP-dependent protein kinase catalytic subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha-1
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit alpha-3
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit alpha-4
- Sodium/potassium-transporting ATPase subunit gamma
Sequence:
MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
Protein: WD_REPEATS_REGION domain-containing protein (Q93758)
Organism: Caenorhabditis elegans
Interaction partners:
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
- Hypoxia-inducible factor prolyl hydroxylase
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
Sequence:
MATNGHAVNGEAHVMQQVAQQPAPPGPLAPQGIGRQNEIVIGGRDRRCEIYKFTSDQQLYASAWSNKNDIKFRLAVGTVSDVSVNPCAANKVSIVQLKDETGELVETASFPMEFPANAVGFIPDPDNVYPDLIATTSDCLRLWRVVDGKVHPDAVMINNTNSQYGSALTSFDWNELEPRYIGVSSVDTTCTIYDVEVGCAIGQTKPTAPFTLKTQLIAHDKPVHDIEFAKINGGRDHFATVGADGSARMFDLRHLNHSTIVYEDPNKEKLQRLSWNKQEPYFMALFAENSQEVQILDIRMPCNILCRLRNHTGPVNGIAWAPHSPHHICTAGDDSQALIWDLQQVPRPVDDPILAYSAGGEVNQIHWGPVHSNWIAICFNKTLEILRV
Protein: 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B) (O95264)
Organism: Homo sapiens (Human)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Cell membrane {ECO:0000269|PubMed:21138434}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:21138434}.
Interaction partners:
- 5-hydroxytryptamine receptor 3A
- 5-hydroxytryptamine receptor 3D
- 5-hydroxytryptamine receptor 3C
- 5-hydroxytryptamine receptor 3E
- 5-hydroxytryptamine receptor 1E
- Glutamate receptor ionotropic, NMDA 3A
Sequence:
MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
Protein: Dihydroxyacetone phosphatase (EC 3.1.3.-) (A4QFW4)
Organism: Corynebacterium glutamicum (strain R)
Function: Catalyzes dephosphorylation of dihydroxyacetone phosphate (DHAP) to produce 1,3-dihydroxyacetone (DHA). Is the main enzyme responsible for DHA production from catabolism of sugars (glucose, fructose, and sucrose) in C.glutamicum. Displays no activity toward nucleoside monophosphates (AMP, CMP, GMP, or UMP).
Interaction partners:
Sequence:
MTVNISYLTDMDGVLIKEGEMIPGADRFLQSLTDNNVEFMVLTNNSIFTPRDLSARLKTSGLDIPPERIWTSATATAHFLKSQVKEGTAYVVGESGLTTALHTAGWILTDANPEFVVLGETRTYSFEAITTAINLILGGARFICTNPDVTGPSPSGILPATGSVAALITAATGAEPYYIGKPNPVMMRSALNTIGAHSEHTVMIGDRMDTDVKSGLEAGLSTVLVRSGISDDAEIRRYPFRPTHVINSIADLADCWDDPFGDGAFHVPDEQQFTD
Protein: Chandra protein (MS4A4B protein) (Membrane-spanning 4-domains, subfamily A, member 4B) (Q9ES61)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Membrane-spanning 4-domains subfamily A member 6B
Sequence:
MQGQEQTTMAVVPGVAVPSKNSVMTSQMWNEKKEKFLKGEPKVLGVLQVMIAIINLSLGIIILTTLFSELPTSVMLMVPIWGSIMFIVSGSLSIAAGVTPTKCLIVASLTLNTITSVLAATASIMGVVSVAVGSQFPFRYNYTITKGLDVLMLIFNMLEFCLAVSVSAFGCEASCCNSREVLVVLPSNPVETVMAPPMTLQPLLPSEHQGTNVPGNVYKNHPGEIV
Protein: Rhino (Q49BL1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRNHQRPNLGLVDAPPNDHVEEYVVEKILGKRFVNGRPQVLVKWSGFPNENNTWEPLENVGNCMKLVSDFESEVFRLHRKAAAKSVGKSKSSPSSSGPLITENGPSSSKKTQQHSKSVQAKNTAGMSKMNQKKGKNIKKTAGKIKDIENYPKTQMPSTSQVSTDSTEVFDGNPSATTTNMIKSPRIQSLFSDLNWIEPTKDKDVGDTSLKTPPKSRRLIEFPQREDAPLSSKHVSPMLIRKESQPLQSSCTDDSDLGESSSSMSLPTVSSTSSEKSIKVTKSEPKTLGQIKFSSRSSDGGHAASSLGAPKEGDIGLDLSGRDSMDSEVESMRRCPRRKRKKTYPNWKFPEITKPFGVNRGLDLDEILHCYQMNDDLFMFVTWKGCSSIDAVHINDIKEAYPLQIIKYFESLRIIVPK
Protein: Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] (P16613)
Organism: Ovis aries (Sheep)
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Vasoactive intestinal polypeptide receptor 1
- Vasoactive intestinal polypeptide receptor 2
- Secretin receptor
- Growth hormone-releasing hormone receptor
- Pro-glucagon
Sequence:
MTMCSGARLALLVYGILMHSSVYGSPAASGLRFPGIRPENEAYDEDGNPQQDFYDSEPPGVGSPASALRDAYALYYPAEERDVAHGILDKAYRKVLDQLSARRYLQTLMAKGLGGTPGGGADDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIPYL
Protein: Sorting nexin-17 (Q15036)
Organism: Homo sapiens (Human)
Function: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11237770, ECO:0000269|PubMed:21512128}. Early endosome {ECO:0000269|PubMed:14739284, ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:28892079}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11237770, ECO:0000269|PubMed:16712798}; Peripheral membrane protein {ECO:0000269|PubMed:11237770}; Cytoplasmic side {ECO:0000269|PubMed:11237770}.
Interaction partners:
- P-selectin
- Krev interaction trapped protein 1
- Sorting nexin-1
- Low-density lipoprotein receptor-related protein 8
- Krev interaction trapped protein 1
- Vacuolar protein sorting-associated protein 35
- Sorting nexin-2
- VPS35 endosomal protein-sorting factor-like
- Sorting nexin-5
- Glia-derived nexin
Sequence:
MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL
Protein: 4-hydroxyphenylacetate 3-monooxygenase reductase component (HPA 3-monooxygenase reductase component) (EC 1.5.1.37) (FAD reductase (NADH)) (p-hydroxyphenylacetate 3-hydroxylase small component) (HPAH small component) (Q9HWT6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Reductase component of the 4-hydroxyphenylacetate (HPA) 3-hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant.
Interaction partners:
- 4-hydroxyphenylacetate 3-monooxygenase oxygenase component
- Homoprotocatechuate 2,3-dioxygenase
- FMN reductase
- Nitroreductase domain-containing protein
- NADPH-dependent FMN reductase-like domain-containing protein
- Riboflavin biosynthesis protein
- Acid phosphatase
- Riboflavin synthase
- Probable hydrolase
- p-hydroxybenzoate hydroxylase
Sequence:
MSQLEPRQQAFRNAMAHLSAAVNVITSNGPAGRCGITATAVCSVTDSPPTLMLCINRNSEMNTVFKANGRLCVNVLSGEHEEVARHFAGMTEVPMERRFALHDWREGLAGLPVLHGALANLQGRIAEVQEIGTHSVLLLELEDIQVLEQGDGLVYFSRSFHRLQCPRRAA