Protein: Klarsicht protein (Q9Y0E4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (By similarity). Plays a role in the nuclear positioning and links the nucleus to the microtubule organizing center (MTOC). Collaborates with Klar to promote even spacing of the myonuclei at the periphery of striated muscle fibers by mediating a tight association between a nuclear ring structure of Msp300 and the plus ends of a unique astral microtubule (MT) network.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:32066907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10556085, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:18820457, ECO:0000269|PubMed:22927463, ECO:0000269|PubMed:32066907}. Nucleus membrane {ECO:0000269|PubMed:14617811, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:18820457}. Nucleus envelope {ECO:0000269|PubMed:14617811}. Note=Associated with microtubules, both apical to the nucleus and also at the basal-most area of the eye disk (PubMed:14617811, PubMed:15579692, PubMed:18820457). Koi is required for perinuclear localization of Klar (PubMed:18820457). Nuclear envelope localization requires nuclear lam (PubMed:14617811). In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) (PubMed:32066907). {ECO:0000269|PubMed:14617811, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:18820457, ECO:0000269|PubMed:32066907}.
Interaction partners:
Sequence:
MEMQQENETGREGVIPNSEKEVALISNQETEKAAMISGGKEGSVRDLESPNETATTQKIEHTTKPLKLDGIFAMPATPPNKAGLATKSASSSRSSSLKKQRRGSRGSANLNVAGMGDGAPKRSAPGGGQLNYGTNSVGNDLMKQSQSMTSLKASNEEQQESRDVIQAKLHLERPYNSLKKNSHSNKMHRYSWGSGNSQCSSTSLHSSATLGLGSSGKDDLWAAIQTNYNYIMDTNLLDTCKEARCEIEGAATVLEKSSECSFKMLDETQRPEGLCEDPKELRRSWREMENKLESSPTITELTLFGNAELQRHLAVHSVLYHEIASHARVVSSCIRAAEKEQQLQQQQQLSSQQPASLTSNCSSESTSESATKSSSLSSGFASDPVTTPIGTAAAAPPSSSTHPSKKGEGNLERLRDRYHLLYLKAFELQLCLDNLLRKRSSAANGLDDDEDEEEDTEDDSFGYEGEATEDDLNEVNSDLDLENSESKSATPAELILQRCQIAATQIVCGLDETQSQSRSQQVPSQAKSPSADQPRDCLAPQKPGDEADEELEEEDEDPDIGTDVVDFLIAKRSWRQVNHPNPSGTATLTDFEADSESSDFEQVQQLSRRGLPPTVGSTRRVLNLIEMPQSSNTNISSSNSLLQQRNHNIGNKMLPNKAHGKNIAVAVITPNSHGNTSHGHGLGHGLGHELNKSPLGLRKTRHHHNDTSKFNRSNRKSKNCAIFYFKHLDTDNEQGNAAGSDLQSEDDPSLIHRRRAGGDILKSADASTDDDDEGCLYTATAAATLEVATAATAAPTAAAATSSVDGLQSTAVSSTTATGGPLPPSDDSDKENKVALVSASTITAARTATATSIATLHSSNYDSSSACSSSNSNSNSNSNSNGRLTETSATSRVTQLQMQIHSQSQSQSQMELQINGNAIDGRHIISNNNCYSSMQHQPQNNNEGEAAEDLAKIKMGDDEAAADMANGNATKSQQMSNGVYSRADSCNFTVWAAETVASCHLPPRSPAKSAKSTKSQASNATVSGSTLVSPVKGKVSHDSIKQLVLKAEHLVRDAQETALKTPTKQKHSIIKISSTVKKREVTMPHPIKQRVEEWLEHQPSTPQLLTRSHTNELLPSCKPDDCEASGEASETDSVPQAGAGVNGGAPNGAGSDTSEGFTDSIATCMQTSTNSYGNSTERIGGSAEPIGQPVTPLGFGSSNQSLNVKIVKRSQTRRKSERPWSVSCLSQLTTDAAQLTTARIVENSPSGLASHSISESALDSLSPGPRPRAASSSGTGSNAAKKADSKGSLRRRKARKKRISAASAGRKSDSGSELGGDLTQTLMKSCESMSSQQLQEFTNALLSIQKGAVVAPLSPKGEVSGVPSLHDGEGGETQLMLPKFRVGSFTTAGLLATDTRLGALAALSNYMNEDEQQAELSTEDHHSSISETAWDNYQEKYNSENYSEGFDSDAARRLLEFGDDYRNFIDSQSDCCSSLSAANNLDSFSPPRMDSLQKHELKSLHINQDTITSSVDHARRQRALELQYERRRKTLEVRRKSCQDMDESLMASPQSDQQQQQLQVTPSLSASATALMTTPKNQSTSHQISHRAESVGRKLDFGGMSHSAQSLLRRTSESDTSTRRRRTVTADERRRSSRNLEKCIKLIPATTSSSSGSDSEDGEQEMRSLLQQSRDRLDDTRALKIRCHLLRPEDYNEIINTCRDNIRCLEAVLRGPPGTVLSNHCAGQTKDLLGAWEDLLSWSENASAARKLQQEMSVLKSSLQRLGDKPTPELLDTEPAIQIAVEALKLEQTQLTSYRTNMLRLNASVHSWLTKQERRLQSALEEQEQQQESEQLKQQKLVEEEKGADVQKELASTGAVAITVTDSNGNQVEALATGEASTSTPAWDVHSLMSSEQEFHKHLKNEVSDMYSAWDEADARINTQLEMLTNSLIAWRQLESGLSEFQLALGQDRGTLKGLEGALDKGQATPVELAQNVKLVAKLLSEKVHVSQEQLLAVQQHLDPNHIYHITKFTASNGSLSDSGISDGGATSDGGLSERERRLGVLRRLAKQLELALAPGSEAMRSIAARMESAEADLKHLQNTCRDLIVRTAASHQQKQQIQQNQTQQVSPKANGHIKKQAAKGKAEPQSPGRRGKGARKARQAKKAGEDQQVEEPSLSPEQQKMVLKQLKTLTSGDGGDDPSDDPSLLFNLESSEEDGEGADPAQTSKRGWAWRIARAAVPMQVALFTIFCAACLMQPNCCDNLNNLSMSFTPQLRYIRGPPPI