wanglab/gogpt-training-data huggingface dataset:
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4) (Q9BRC7)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Protein kinase C beta type
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Protein kinase C alpha type
- Inositol polyphosphate multikinase
- Inositol polyphosphate-5-phosphatase A
- Protein kinase C gamma type
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
Sequence:
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES
Protein: Mediator of DNA damage checkpoint protein 1 (Q5PSV9)
Organism: Mus musculus (Mouse)
Function: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q14676}. Chromosome {ECO:0000269|PubMed:15611643}. Note=Associated with chromatin (By similarity). Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AX (By similarity). Colocalizes with APTX at sites of DNA double-strand breaks (By similarity). {ECO:0000250|UniProtKB:Q14676}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF8
- TP53-binding protein 1
- Histone H2AX
- Serine-protein kinase ATM
- Breast cancer type 1 susceptibility protein homolog
- E3 ubiquitin-protein ligase RNF168
- BRCA1-A complex subunit RAP80
- DNA topoisomerase 2-binding protein 1
- Structural maintenance of chromosomes protein 3
- Nibrin
Sequence:
MESTQVIDWDAEEEEETELSSGSLGYSVEPIGQLRLFSGTHGPERDFPLYLGKNVVGRSPDCSVALPFPSISKQHAVIEISAWNKAPILQDCGSLNGTQIVKPPRVLPPGVSHRLRDQELILFADFPCQYHRLDVPPPLVPRSLLTIEKTPRIRIESQNSRVLLAADSEEEGDFPSGRCVANGQRNTASPSATVVPESDEEVSSPAPSVPGPSSPFGLGSDTDEEQGQQPGVEESSLADSSGAAGEAEQPEANGTTAGIQAQPTEHKLKDTKVKKEAGRAGVSDGSVLERSPTLGEDSDTEVDEDHKPGFADSETDVEEERIPVTPPVAPVKKNQVLLAVGIGDPEAPGVAHLQDCLAGSGTDVEDKTALDVPLERNHTPMVINSDTDEEEEEEEEVSAALTLAHLKERGIGLWSRDPGAEEVKSQPQVLVEQSQSASGRDSDTDVEEESSGRKREIIPDSPMDVDEALTVTQPESQPPRRPNDADEYMDMSSPGSHLVVNQASFAVVGKTRAQVEEEVPGPSVILGEKHQVPLEGAQPPEEAWETAVQEGSSSPEAAASVRPSQQPVAEDAGTECATAVSEQESTLEVRSQSGSPAAPVEQVVIHTDTSGDPTLPQREGAQTPTGREREAHVGRTKSAKECCDAEPEDLCLPATQCFVEGESQHPEAVQSLENEPTQLFPCTLPQEPGPSHLSLQTPGADTLDVPWEVLATQPFCLREQSETSELHEAHGSQPSLPREPPGHQHLVHTSPVHTELLRIEGREIQTVEKAMGIPKEMADRMTPEREPLEREIRGRTENSERDVIGEELIQGTKDREPKKVLARDSQRKEADKDLEGNRESLEVEIEMSKDSQKRERKVEKPEPKREWEPADLEVTPDRGVTEEGSHDQKGQIASLTLKPGVGVKDLEGLASAPIITGSQADGGKGDPLSPGRQQRGRLSCQTTPAGKASRGDPEPPDHCLFSSVPEASTQSLLTSQSQKQSTPQPLFSTSSSEIPLPESLHTKPNVRPRRSSRMTPSPHSSAALKPNTTCPTNQPAASRPTSRPTRGRANRSSTRTPELIVPVDPELQPSTSTEQPVIPKLTSQVTEGRVQMPEPLLTGPEIQSPTSTEQSVTPDRKPRATRGRPSKSPNKTPEPLISTGPELQPPTSIEQPVIPKPTSRVTRGRPRKSSVRTPESVVSTGPELQPLTSIEQPVIPEPRATRGRPSKSSIKTPESVVPTGPELQPLTSAKQPVTPNLTSRASRGRSSKSIRTPEPVVQTGPEFHPSTSTEQPDTREPSSQARTRRSAVKTPEASVPTTPELQPFTSKKQPAPKPTALVTQGRTYKPSTEDCESVGPVAPDFEPSTSTDHLVTPKVTDQSLTLQSSPLSASPVSSTPDLKPPVPIAQPVTPEPIPQANHQRKRRAAGKQGSRTVPLGHKSYSALSEPEPQSSASQSSGASEADSPRQKRPRRQASQKTVVIKEEPVETEVKEEPQETAIPTPEKRKRDHAEEVTQGKPTRSRRTKPNQETAPKVLFTGVMDSRGERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCALGKGIPILSLNWLYQSRKAGCFLPPDDYLVTDPEQEKNFSFSLRDSLCRARERRLLEDYEIHVTPGVQPPPPQMGEIISCCGGTFLPSMPHSYKLHRVIITCTEDLPRCAIPSRLGLPLLSPEFLLTGVLKQEATPEAFVLSNLEMSST
Protein: Protein FAR1-RELATED SEQUENCE 11 (Q9SY66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription activator involved in regulating light control of development.
Subcellular location: Nucleus {ECO:0000269|PubMed:15591448}. Note=The nuclear localization is independent of the light treatment.
Interaction partners:
- Histone acetyltransferase subunit NuA4-domain protein
- Histone acetyltransferase of the MYST family 1
- Proline-rich receptor-like protein kinase PERK9
- Large ribosomal subunit protein eL36y
- At1g17080/F6I1.24
- Large ribosomal subunit protein eL29y
Sequence:
MSDDPGQMLLIYDDPSDQRSLSLDDASSTEESPDDNNLSLEAVHNAIPYLGQIFLTHDTAYEFYSTFAKRCGFSIRRHRTEGKDGVGKGLTRRYFVCHRAGNTPIKTLSEGKPQRNRRSSRCGCQAYLRISKLTELGSTEWRVTGFANHHNHELLEPNQVRFLPAYRSISDADKSRILMFSKTGISVQQMMRLLELEKCVEPGFLPFTEKDVRNLLQSFKKLDPEDENIDFLRMCQSIKEKDPNFKFEFTLDANDKLENIAWSYASSIQSYELFGDAVVFDTTHRLSAVEMPLGIWVGVNNYGVPCFFGCVLLRDENLRSWSWALQAFTGFMNGKAPQTILTDHNMCLKEAIAGEMPATKHALCIWMVVGKFPSWFNAGLGERYNDWKAEFYRLYHLESVEEFELGWRDMVNSFGLHTNRHINNLYASRSLWSLPYLRSHFLAGMTLTGRSKAINAFIQRFLSAQTRLAHFVEQVAVVVDFKDQATEQQTMQQNLQNISLKTGAPMESHAASVLTPFAFSKLQEQLVLAAHYASFQMDEGYLVRHHTKLDGGRKVYWVPQEGIISCSCQLFEFSGFLCRHALRVLSTGNCFQVPDRYLPLRWRRISTSFSKTFRSNAEDHGERVQLLQNLVSTLVSESAKSKERLDIATEQTSILLSRIREQPVSSLAIRDISSSVQRNF
Protein: DUF4902 domain-containing protein (B4EMD1)
Organism: Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Interaction partners:
Sequence:
MTSPLLHPVPGPSPDGYVRLSEGALAALVLDHVASGLDPSLLAELRDNAIDARLAGYTEWHRTAGAGVAYVTVGWDWYLERATGTFVIAGGDVRSNVMAIDAKGADIGMLRTAAALAARLAALDWPAAVASALLGHNDAYHAGPTLQ
Protein: Microcephalin (Q7TT79)
Organism: Mus musculus (Mouse)
Function: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
Interaction partners:
- Histone H2AX
- Abnormal spindle-like microcephaly-associated protein homolog
- Protein SET
- Condensin-2 complex subunit G2
- SCL-interrupting locus protein homolog
- Breast cancer type 2 susceptibility protein homolog
- Telomeric repeat-binding factor 2
- Serine-protein kinase ATM
- WD repeat-containing protein 62
- Centrosomal P4.1-associated protein
Sequence:
MEASGGVGGAFLKDVVAYVEVWSSKGTENYSRTFAKQLEDMGATVSKTLNKQVTHVIFKDGYQSTWDKAQKTGAKLVSVLWVEKCRMAGALVDESLFPAVNTDEHLPNLSRKKHKCMQPKDFILKTPENDKRLQKKFEKMAEELQRQKAALDDDVPVLLFESPRSLVYSSPVNVMKRRLQDMKEKRENLSPTSSQMLEQSQQNPCVSLFETSLNISHQPLSSDESFASGSHSSFGDSCGDQERKLGRSANEMTTVTCPSSPVLRASSFYGSASPNHLRQPRPQKAPDSPSKESINCQKDATGAVADSERKQAAGVSQGVPDEKLCLSPTMSIIEEHQVRLGPKNSSAKRKRAADLGSSPKGKLKKRYKRKSALAIQLFKSDQSPPSTIRLIPGTPDVEASSYEDYFSPDNLKERNSERLPPEAQQLASPSLFHCRGLSKWERRNMLEMCDFTCIGEKHRSISSISDLISKSASSLEKPVKEEVNTASTCLLLVETSANDSPGLCSQPGPQLRDDTGPEGSSHPDTLSSSAHHITPLKGNSTETRDPGDGKGSPKEGSTPPASASPEDEVHICNLSLGEDCNVEKSVEEKENIATGYSESVKNGPGRPDPSDSSCTGLVRPQQKPKKSEKEEKPTRTLVMTSMPSEKQTLIIQVVSTLKGFSFAPEVCETTTHVLVGKSARTLNVLMGIARGCWILSYEWVLLSLELGHWISEEPFELSETFPAAPICRLERHLSTQQYQGTLFANQPKMFIAPASSPPRAKLCELVLLCGGQVSPAPQLASLIIGPYKGKKKARIQYLSEKWVLDSITQHKICDFNNYQLLQ
Protein: Type III secretion regulatory protein ExsE (Q9I322)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Acts as a negative regulator of the type III secretion regulon (T3SS) expression. In the absence of inducing signals such as low Ca(2+) or host cell contact, the T3SS/injectisome is expressed at a low basal level and exists in a quiescent state due to ExsA sequestration by ExsD. ExsE binding to ExsC disrupts the complex between ExsC and ExsD, thereby allowing free ExsD to bind ExsA. Upon inducing signal, ExsE is secreted allowing ExsC to bind ExsD. In turn, ExsD cannot bind ExsA and prevent ExsA-mediated transcriptional activation of the type III secretion system.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15911752}. Secreted {ECO:0000269|PubMed:15911752}. Note=Secreted under low-calcium conditions. {ECO:0000269|PubMed:15911752}.
Interaction partners:
- Transcriptional anti-antiactivator ExsC
- Type 3 secretion system pilotin
- Transcriptional antiactivator ExsD
- HTH-type transcriptional regulator ExsA
- Translocator protein PopB
- Translocator outer membrane protein PopD
- Regulatory protein PcrH
- Exoenzyme T
- Type III secretion protein PcrV
- Secreted exoenzyme S
Sequence:
MKIESISPVQPSQDAGAEAVGHFEGRSVTRAAVRGEDRSSVAGLARWLARNVAGDPRSEQALQRLADGDGTPLEARTVRRR
Protein: Zinc finger protein 574 (F1QUN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Augmin-like complex subunit 3-like protein beta.
- Myc target 1b
- Si:dkey-220o5.5.
- Golgi glycoprotein 1a.
- Pleckstrin homology domain-containing family J member 1
- G patch domain-containing 1
- Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit.
- Myc target protein 1 homolog
- Death effector domain-containing 1.
- Actin filament-associated protein 1-like 2
Sequence:
MESSSVYMCFPCYREFPTLEEVLAHQMTCTAENPQLLPNETPVEAAAAAAGLPQVAMQAVTVPQIQTQTAVDLSSLLQQKKTIQADAPRVLYQCADCEVLFDALSLWQQHRKMGCCLETEPAGEQTEETYEAVAQPQPSQKENENAVQEQNTPEQTQVKEVVEIRFESVSQGSVEVAGKVAAPATSEEEESSNSVSKEASATHEASSVETSAEASSPATRRRGQKKAKPPSSLLCVECGQSFSLVPELVTHRRTQHGLKDAIHRCAVCGEGFLNTTLFLYHRRQHRSEVEEEPKQASSGIPQISTAMLEAPGEGLLLLATAGEGQSLMEVTTLEQTITETPVAQVEVELEGNEIRGTEQEPMVEGAEILVEKTEEMLEEHEAPDQEVKMELVIEKVEGNVQMEKIGADEEIQDAVESNASENTSTAFLCHQCGSVFSNDQELAKHRKAEHGLEAALHTCGDCGAKFMSTTQFLYHRRQHKNTTAGHLVTAEVKSRLYTTAASATGAAAADGGLEAPAKLSREWSRTALPHECPHCGQGFTRRSRLREHVFQHTGEKLFNCKICKKSFPSPANLLRHSLIHGGSRIYSCPICDKRFFQPTSLKRHMMTHQEGVQERRTRGRGKGRGPSSDGRLHICPECPASFKLEAQLKSHRLLHTSHPFPCSVCGEAFIRRKELDLHSLIHQDKEPKMCPNCGSQFLNQTVLDTHLQRCTGEQTGQRKYKGQGRGKVGGQLECDMCGHRCVTQDGLDLHRLSHTGQTPLRCPLAPCRRRFASSAALGEHLVAHCCGALGKRNAPRRFTCEFCGKEFAYASTFTVHMRTHTNERPFECAQCGKRFRQLPHLQDHERIHSGERPFTCWVCGKSFSVAARLTEHARVHSGERPYVCPRCPTAFRSRPNLDKHMRIHANDPVDPTAQNVMDDDAAVQTILLVQESASSSPSSSSSVMPVVQEGMFVTEEGGSSVVFLHPNMSMPTITVPAISVPSMNMPNISVVAGQDVPHTIEVILEETV
Protein: Protein Wnt-5a (P41221)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Frizzled-2
- Tyrosine-protein kinase RYK
- Frizzled-4
- Frizzled-5
- Frizzled-3
- Frizzled-9
- Tyrosine-protein kinase transmembrane receptor ROR2
- Frizzled-7
- Frizzled-6
- Inactive tyrosine-protein kinase transmembrane receptor ROR1
Sequence:
MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK
Protein: Integrase (Q94MV5)
Organism: Myxococcus phage Mx8
Interaction partners:
Sequence:
MGNVYRKKATRYLWMWWFDAAGARQYASTGEEDEVKARAVLKATEKRVAAEKDQGLGASGPVTVEAYAAKWMEGRVTLRSVMDDRSRMQHHVLPSLGDKELGVLTRRHVLALVREVRAKGLAPRTVRHVYALVRTMLSDAVVDGLLERSPCDLRERRGEIPAIRDADPRWRDSAVYSRAEVVALITDERIPLERRVLYAVAFVGAVRIGEASALQVRDWDGTVNPLGKLWVTKTFNHKVGEVYETTKTDTPRQMPVHPWLSTMLASWLAYGWARMYARTPRQDDLILPSPTGMHQRPQGVLRRLHADLDLLGFRRRRTHDARRTFISLARADGADKYLLQWVTHGRRSDMVDAYTTPPWDALCREVAKLKLELPKQEEETMACRVPSCDSGVTADAGKEKPQQVRELAGAGVARSTGLEPVLLGSFYANPRQLPTKSEGLDAESAKLARTGAVDWHKPVTAPHPLAVVRQQMGVLKSGAGRERKVLASQLVDASLMALERLAAALHRTHAADDRWSDCPACRAVADGESPSAT
Protein: Uperin-3.5 (P82042)
Organism: Uperoleia mjobergii (Mjoberg's toadlet) (Pseudophryne mjobergii)
Function: Shows antibacterial activity against B.cereus, L.lactis, L.innocua, M.luteus, S.aureus, P.multoci, S.hominis, S.epidermidis and S.uberis. Strong activity against M.luteus (MIC=2 uM) compared to S.hominis, S.epidermidis and S.aureus. Acts by inducing permeabilization of bacterial membranes. Forms amyloid fibrils which, in the presence of bacteria, aggregate on the bacterial membrane leading to severe membrane damage and cell death.
Subcellular location: Secreted {ECO:0000269|Ref.1}. Target cell membrane {ECO:0000269|PubMed:33431675, ECO:0000269|Ref.3}. Note=Secreted monomers and fibrils appear to be able to interact with target cell membranes. {ECO:0000269|PubMed:33431675, ECO:0000269|Ref.3}.
Interaction partners:
Sequence:
GVGDLIRKAVSVIKNIV
Protein: Probable binding protein component of ABC transporter (Q9I2T4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable solute-binding protein
- Probable permease of ABC transporter
- Inner membrane ABC transporter permease protein YejB
- ABC-type dipeptide transporter
- Probable binding protein component of ABC transporter
- Inner membrane ABC transporter permease protein YejB
- Probable permease of ABC transporter
- Enoyl-[acyl-carrier-protein] reductase FabI
Sequence:
MIRPRFTPLLAALLLGCCGPLLAAPKHALTLYDEPPKYPADFKHFDYVNPDAPKGGILRQADFGGFDSLNPFIGKGVSAPSLGLIYDTLAFQSQDEPFTEYGLLAEKIEKAPDNSYVRFYLRPQARFSDGTPVTAEDVVFTFETLVSKGDPMYRNYYADVDKVVAEDKLRVRFDFKHAGNRELPLILGQIAILPKHWWADRDFSKTGMEIPVGSGPYRIAKVDPGRSISYERVKDWWAKDLPVSRGLYNFDTITIDSYRDMSVALEAFKAGQYDVNLEYSAKDWATGYESPALRDGRFIKASIHNHNPVGMQGFAFNIRRPVFQDRRVRQAISLLFDFEWSNKQLFFSSYKRTNSYFENSEMAAHQLPSEAELKILEPLRGKIPDEAFDQVFQNPVNDGSGVIREQRRKAYQLLTEAGYRIENNRMVGPDGQPLSFEFMLFQANMERVILPFKRNLAELGIDMQIRRVDVSQFVNRLRSRDFDMTSATWPQSNSPGNEQREFWHSSSADKAGSRNFIGLKDPAIDSLVESLIQSDSRQSLIDHTRALDRVLSWGYYVVPNYYVDTWRVAYWNRFGRPKVTPLYDWGLMTWWQTSDKALPSKAQAEATQDAEPERE
Protein: RNA-directed RNA polymerase (EC 2.7.7.48) (G5ECM1)
Organism: Caenorhabditis elegans
Interaction partners:
- Helicase ATP-binding domain-containing protein
- Piwi domain-containing protein
- MUTator
- Piwi-like protein ergo-1
- PAP-associated domain-containing protein
- Nuclear RNAi defective-3 protein
- DRBM domain-containing protein
- Piwi domain-containing protein
- NFX1-type zinc finger-containing protein 1 homolog
- Exonuclease mut-7
Sequence:
MSERSHGFIKFEFPEFDNSLQVIEGSIDTMLLTFTSVLRKYEIEIKSRQETQIVEEQDCDCFFEINFEVESEQFDHTIIDAMHDYLSDLNVYVPYQRPNIVLHGSDFWLRTLDCHTEIPLAAIYFGNIQGGTYFNHWQVSFSRENISSRDMLHKIHAEFEFDKTDMITVQFQCFEEKKQKFEDSRKQKVRVNYQLTIRRDSIRRIIVDPRVEGCNTCVHFEVNCPPLIRKGYIDNDKSSFHKPFYERQKRFDCDWRNGNVNHGNPQDAAIADSPFFTIEFHKEISTKEMYRVLSRLRSRTKVLIEFANLPSIDVPMGSHYPYNRWNLKKSPTDSNAPIFREFLKEIFPPKYEIVDDKLIDVNEERKFSITYLIECLLSRGAIVKDQLLLNEQHWKNFLEIIIWYYRNDNQLCEAALEDLVHLIDGRKRIGSILKCLDKICQKREVMKLVNGLTEKESIEGYQRVRKVIFTPTRVIYIAPETIMGNRVLRKFDKDGTRVLRVTFRDDNNKKMRSNVTGKLLDRTANKYLEHGVRIANREYGFLGCSNSQMRDNGAYFMMRFTDKQLDRFYKCNPTASNINFKPKIDEVRFQLGRFSEIENVPKLMARLGQCFTQSRLTGVGLGRDDYCSTYDLTGGRATNGSEYTFSDGVGMMSYQFAQEVSQAMQFGKAVPSCFQIRFRGNKGVIAIEPFLDEIRKWALVNGVTSMKMAKCLFRPSQIKFQAKAISGDQIEMVKFSSAVLVALNKPFINILDQVSEMQSLDCHKRITSRIEELMDRQILSFAKQMNEETFCRNKLKEFPRRIDIDNLRTMWGFTLSSEPFFRSLIKASIKFSITKQLCKEQIQIPSELGRSMLGVVDETGRLQYGQIFVQYTKNYKKKLPPRDSNNKVHGSEIVTGTVLLTKNPCIVPGDVRIFEAVDIPELHHMCDVVVFPQHGPRPHPDEMAGSDLDGDEYSVIWDQELLLERNEEPFDFAVEKIKVPYDREKLDVLMREFYVTYLKLDSVGQISNSHLHNSDQYGLNSRVCMDLAKKNCQAVDFTKSGQPPDPLETKWRADPVTFEVIPPENPERIPDFHMGNERSPMYVSPRLCGKLFREFQAIDNVIKISEERDEQYNIELDETIFVTGFERYMESAQKQLSSYNGQLRSIMENYGIRSEGEIMSGCIVEMRNRISDKDQDDMSFYNTNQMIETKMTSLVCKFRETFFEEFGGFTVKCTLLPNAYDNGNCLNYRCEDPDQEVRKKAVAWYRACYECAQSTREVRKLSFAWIAYDVIAKVKETNVLNNERMQIGGANPMYTFLEEHRKQYLIDHDADFKNFCELDHLITGEKSKEAISILKIYLEMIPGLDSVFFMLMRWGESLRLFDGKPIKIYHFFLMFILFATRQLASADGNAEPFFKIIEKEEYEKQKRDSSRGNIDPLTEKKRSDMMVKFFQFMGCRKFRKMSTLSFCPLNFSSIFMRGEWRIFHESALKTYYNILFNLRFEELPVSSDPTITAETMDRECEPFVIELPENINVNDLINNMKKHTNVSTVKMRRQEKNPINDKAKPKTTVRYIVSVSGTLESIQMLKKLSAVTIPIKSHWEGEEVSQQMASLCYQKVMNGEF
Protein: U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) (A0A0A0MRR7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|HAMAP-Rule:MF_03153, ECO:0000256|PIRNR:PIRNR037969}.
Interaction partners:
Sequence:
MNSASVDGHLSGCRLFLFLSPLFRFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR
Protein: NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (P76558)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the decarboxylation of malate to pyruvate. In vitro, shows malolactic enzyme activity in the presence of NADPH. However, it is unlikely that this activity is of relevance in E.coli, which produces little NADPH.
Interaction partners:
- Malate dehydrogenase
- Malate synthase A
- Pyruvate kinase I
- Phosphoenolpyruvate synthase
- Pyruvate kinase II
- Fumarate hydratase class I, aerobic
- Pyruvate dehydrogenase
- Malate synthase G
- Citrate synthase
- D-lactate dehydrogenase
Sequence:
MDDQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLKAYKYTARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFIEVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGLQKHNIVVCDSKGVIYQGREPNMAETKAAYAVVDDGKRTLDDVIEGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKEVRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIADFDVYIDKLTEFVYKTNLFMKPIFSQARKAPKRVVLPEGEEARVLHATQELVTLGLAKPILIGRPNVIEMRIQKLGLQIKAGVDFEIVNNESDPRFKEYWTEYFQIMKRRGVTQEQAQRALISNPTVIGAIMVQRGEADAMICGTVGDYHEHFSVVKNVFGYRDGVHTAGAMNALLLPSGNTFIADTYVNDEPDAEELAEITLMAAETVRRFGIEPRVALLSHSNFGSSDCPSSSKMRQALELVRERAPELMIDGEMHGDAALVEAIRNDRMPDSSLKGSANILVMPNMEAARISYNLLRVSSSEGVTVGPVLMGVAKPVHVLTPIASVRRIVNMVALAVVEAQTQPL
Protein: Geranyl diphosphate synthase (EC 2.5.1.1) (Q58GE8)
Organism: Ips pini (Pine engraver beetle)
Function: Geranyl diphosphate synthase involved in pheromone biosynthesis.
Interaction partners:
Sequence:
MFKLAQRLPKSVSSLGSQLSKNAPNQLAAATTSQLINTPGIRHKSRSSAVPSSLSKSMYDHNEEMKAAMKYMDEIYPEVMGQIEKVPQYEEIKPILVRLREAIDYTVPYGKRFKGVHIVSHFKLLADPKFITPENVKLSGVLGWCAEIIQAYFCMLDDIMDDSDTRRGKPTWYKLPGIGLNAVTDVCLMEMFTFELLKRYFPKHPSYADIHEILRNLLFLTHMGQGYDFTFIDPVTRKINFNDFTEENYTKLCRYKIIFSTFHNTLELTSAMANVYDPKKIKQLDPVLMRIGMMHQSQNDFKDLYRDQGEVLKQAEKSVLGTDIKTGQLTWFAQKALSICNDRQRKIIMDNYGKEDNKNSEAVREVYEELDLKGKFMEFEEESFEWLKKEIPKINNGIPHKVFQDYTYGVFKRRPE
Protein: Synaptosomal-associated protein (H3BQY9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
XQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKAKNFKAWTARYLH
Protein: Rhodanese/Cell cycle control phosphatase superfamily protein (F4J9G2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MFPLCSATSCRYHSQILFPGNWRGCSSFRRELIHRYSSGDNAFFGISNGTRLQKSFVPQATGSFLTGTIEKTEQPVSTFGSLCQNELDRINYMVYNMSEAFVASDEGLTYVENGEDVFPVEAVAADVSPVEAVVPDVSPIECLSAETLTDKTSSLIDSVESGTNATVKISPDSSVSLPDAKASFDDFSSGLKQSFSSSLPDAKASVDDFSSGVKESFSSSLNQGENAVKNTLESFSSSVTSITKNASEVVDSAVNRAFSTLDQTGDVAGDKFSSFSTGLKEASNRAAVIAIDLLRQSVSLGERSVTNGVSFVVYSYGSAKELLPPDVKSALNSSEDVALKVLSPVGAVLQQVSVAIGGLERNIGLDPDDPILHLFLFVGTTGTFWVLYRVWTYGGYAGDLSPKSTLDLLKSRDKSVLIDVRPEALREKDGIPDLRRSARFRYSSVTLPEVDGDVKRLLKGGSEVDDILTAVIIKNLKIVQDRSKVVVMDADGTRSKGIARALRKVGIKRPYLMQGGYRSWVQEGLRVKEPKPETTLTILNEEAEAIFEDINPSPLQLFGVGVGFFAALYALSEWEKTLQLIAVIGLSLTIYLRLSSYDDSEDFKQDVRLLLAPVKLGAQAFSWAAGKLETNGVGLPTSPSSSDVRSRVLQAAAKHESKPSDETSESLQDASSSPEEALNNVDVSEA
Protein: Histamine H1 receptor (H1R) (HH1R) (P31390)
Organism: Rattus norvegicus (Rat)
Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7678492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35367}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Histamine H2 receptor
- Histamine H4 receptor
- Transient receptor potential cation channel subfamily V member 1
- Histidine decarboxylase
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-15
- Guanine nucleotide-binding protein subunit alpha
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
Protein: Cytoplasmic polyadenylation element binding protein 4 (D3ZKL3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPNPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKAEENPGDNSSENSNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGASQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDSIKGRLNYSYPGSDSSLLINGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFTHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN