Protein: A disintegrin and metalloproteinase with thrombospondin motifs gon-1 (ADAMTS gon-1) (EC 3.4.24.-) (Abnormal gonad development protein 1) (Q19791)
Organism: Caenorhabditis elegans
Function: Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Required for the secretion of insulin-like peptide ins-7, daf-28 and ins-18 and TGF beta-like protein daf-7. In peripheral tissues, negatively regulates insulin-mediated daf-16 translocation and thereby negatively regulates lifespan and dauer formation.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:10376599}. Endoplasmic reticulum {ECO:0000269|PubMed:22419820}. Golgi apparatus {ECO:0000269|PubMed:22419820}.
Interaction partners:
- Fibulin-1
- Collagen alpha-1
- Putative metalloproteinase inhibitor tag-225
Sequence:
MRSIGGSFHLLQPVVAALILLVVCLVYALQSGSGTISEFSSDVLFSRAKYSGVPVHHSRWRQDAGIHVIDSHHIVRRDSYGRRGKRDVTSTDRRRRLQGVARDCGHACHLRLRSDDAVYIVHLHRWNQIPDSHNKSVPHFSNSNFAPMVLYLDSEEEVRGGMSRTDPDCIYRAHVKGVHQHSIVNLCDSEDGLYGMLALPSGIHTVEPIISGNGTEHDGASRHRQHLVRKFDPMHFKSFDHLNSTSVNETETTVATWQDQWEDVIERKARSRRAANSWDHYVEVLVVADTKMYEYHGRSLEDYVLTLFSTVASIYRHQSLRASINVVVVKLIVLKTENAGPRITQNAQQTLQDFCRWQQYYNDPDDSSVQHHDVAILLTRKDICRSQGKCDTLGLAELGTMCDMQKSCAIIEDNGLSAAFTIAHELGHVFSIPHDDERKCSTYMPVNKNNFHIMAPTLEYNTHPWSWSPCSAGMLERFLENNRGQTQCLFDQPVERRYYEDVFVRDEPGKKYDAHQQCKFVFGPASELCPYMPTCRRLWCATFYGSQMGCRTQHMPWADGTPCDESRSMFCHHGACVRLAPESLTKIDGQWGDWRSWGECSRTCGGGVQKGLRDCDSPKPRNGGKYCVGQRERYRSCNTQECPWDTQPYREVQCSEFNNKDIGIQGVASTNTHWVPKYANVAPNERCKLYCRLSGSAAFYLLRDKVVDGTPCDRNGDDICVAGACMPAGCDHQLHSTLRRDKCGVCGGDDSSCKVVKGTFNEQGTFGYNEVMKIPAGSANIDIRQKGYNNMKEDDNYLSLRAANGEFLLNGHFQVSLARQQIAFQDTVLEYSGSDAIIERINGTGPIRSDIYVHVLSVGSHPPDISYEYMTAAVPNAVIRPISSALYLWRVTDTWTECDRACRGQQSQKLMCLDMSTHRQSHDRNCQNVLKPKQATRMCNIDCSTRWITEDVSSCSAKCGSGQKRQRVSCVKMEGDRQTPASEHLCDRNSKPSDIASCYIDCSGRKWNYGEWTSCSETCGSNGKMHRKSYCVDDSNRRVDESLCGREQKEATERECNRIPCPRWVYGHWSECSRSCDGGVKMRHAQCLDAADRETHTSRCGPAQTQEHCNEHACTWWQFGVWSDCSAKCGDGVQYRDANCTDRHRSVLPEHRCLKMEKIITKPCHRESCPKYKLGEWSQCSVSCEDGWSSRRVSCVSGNGTEVDMSLCGTASDRPASHQTCNLGTCPFWRNTDWSACSVSCGIGHRERTTECIYREQSVDASFCGDTKMPETSQTCHLLPCTSWKPSHWSPCSVTCGSGIQTRSVSCTRGSEGTIVDEYFCDRNTRPRLKKTCEKDTCDGPRVLQKLQADVPPIRWATGPWTACSATCGNGTQRRLLKCRDHVRDLPDEYCNHLDKEVSTRNCRLRDCSYWKMAEWEECPATCGTHVQQSRNVTCVSAEDGGRTILKDVDCDVQKRPTSARNCRLEPCPKGEEHIGSWIIGDWSKCSASCGGGWRRRSVSCTSSSCDETRKPKMFDKCNEELCPPLTNNSWQISPWTHCSVSCGGGVQRRKIWCEDVLSGRKQDDIECSEIKPREQRDCEMPPCRSHYHNKTSSASMTSLSSSNSNTTSSASASSLPILPPVVSWQTSAWSACSAKCGRGTKRRVVECVNPSLNVTVASTECDQTKKPVEEVRCRTKHCPRWKTTTWSSCSVTCGRGIRRREVQCYRGRKNLVSDSECNPKTKLNSVANCFPVACPAYRWNVTPWSKCKDECARGQKQTRRVHCISTSGKRAAPRMCELARAPTSIRECDTSNCPYEWVPGDWQTCSKSCGEGVQTREVRCRRKINFNSTIPIIFMLEDEPAVPKEKCELFPKPNESQTCELNPCDSEFKWSFGPWGECSKNCGQGIRRRRVKCVANDGRRVERVKCTTKKPRRTQYCFERNCLPSTCQELKSQNVKAKDGNYTILLDGFTIEIYCHRMNSTIPKAYLNVNPRTNFAEVYGKKLIYPHTCPFNGDRNDSCHCSEDGDASAGLTRFNKVRIDLLNRKFHLADYTFAKREYGVHVPYGTAGDCYSMKDCPQGIFSIDLKSAGLKLVDDLNWEDQGHRTSSRIDRFYNNAKVIGHCGGFCGKCSPERYKGLIFEVNTKLLNHVKNGGHIDDELDDDGFSGDMD