wanglab/gogpt-training-data huggingface dataset:
Protein: Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Q9DE07)
Organism: Gallus gallus (Chicken)
Function: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (By similarity). RAD50 may be required to bind DNA ends and hold them in close proximity (By similarity). NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions (By similarity). It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX (By similarity). NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation (By similarity). NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints (By similarity). The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability (By similarity). Forms a complex with RBBP8 to link DNA double-strand break sensing to resection (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O60934}. Chromosome {ECO:0000250|UniProtKB:O60934}. Nucleus, PML body {ECO:0000250|UniProtKB:O60934}. Chromosome, telomere {ECO:0000250|UniProtKB:O60934}. Note=Localizes to DNA double-strand breaks (DSBs); recruited to DNA damage sites via association with phosphorylated proteins, such as phosphorylated H2AX. {ECO:0000250|UniProtKB:O60934}.
Interaction partners:
- Non-specific serine/threonine protein kinase.
- Double-strand break repair protein MRE11
- Zinc-hook domain-containing protein.
- Uncharacterized protein.
- RB binding protein 8, endonuclease.
- Uncharacterized protein.
- ATR serine/threonine kinase
- PAX interacting protein 1.
- X-ray repair cross-complementing protein 5
- Uncharacterized protein.
Sequence:
MWKLVPAAGPGEPFRLLVGTEYVVGRKNCAFLIQDDQSISRSHAVLTVSRPETTHSQSVSVPVLTIKDTSKYGTFVNGSKLSGASRSLQSGDRVNFGVFESKFRVEYESLVVCSSCLDVAQKTALNEAIQQLGGLVVNEWTKECTHLIMESVKVTVKTICALICGRPIVKPEFFSELMKAVQSRQQLPTPESFYPSVDEPAIGIDNMDLSGHPERKKIFSGKTFVFLTAKQHKKLGPAVILGGGEAKLMAEERKETSLLVSPEVCVVDVGVTNSQILGSESMRNWTDSILAVLESNNLRAIPEAEIGLAVIFMSTEIYCNPQRQPDNKAVTASTASKVRPVSSQSSTVDETIMPTAAADYSTLNVADTEIEEQTCMEIERTTSQTTRREKVAFQQAAVRENPSTSGTVNAGMLISRVNRTSGFGQKNHPHSPSKILEVDKPRECTPRQQSNSITNYFHVARKRERAEEGEETSLSKQAKLEKKPLPVSECTESSASSAWNSEKEQHGKGNNIQLGRESGELASDKTDIKITFSENPAPKKRKELDDVSEDVETLEMVFESRDLDWEEQTANGDQEAQSNKRKKRCLETKGSRTEEGNTKQREENEMLRKEEVGSVLTLEDKSKIKEESSVSIRNKLINHNKLEDDSSRLPSKLLLTEFRSLVVSCPRSNSPTMRNTKCRGQNNFKTFRKVPYPGAGQLPYIIGGSDLVAHQARKNSELEEWLREELEEQNRRAREESLADDLFRYDPNVKRRR
Protein: Transcriptional regulatory protein SDS3 (Suppressor of defective silencing protein 3) (P40505)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcriptional regulatory protein SIN3
- Transcriptional regulatory protein RXT2
- Histone deacetylase RPD3
- Transcriptional regulatory protein PHO23
- Transcriptional regulatory protein UME1
- Histone deacetylase complex subunit CTI6
- Transcriptional regulatory protein SAP30
- Transcriptional regulatory protein RXT3
- Transcriptional regulatory protein RCO1
- Chromatin modification-related protein EAF3
Sequence:
MAIQKVSNKDLSRKDKRRFNIESKVNKIYQNFYSERDNQYKDRLTALQTDLTSLHQGDNGQYARQVRDLEEERDLELVRLRLFEEYRVSRSGIEFQEDIEKAKAEHEKLIKLCKERLYSSIEQKIKKLQEERLLMDVANVHSYAMNYSRPQYQKNTRSHTVSGWDSSSNEYGRDTANESATDTGAGNDRRTLRRRNASKDTRGNNNNQDESDFQTGNGSGSNGHGSRQGSQFPHFNNLTYKSGMNSDSDFLQGINEGTDLYAFLFGEKNPKDNANGNEKKKNRGAQRYSTKTAPPLQSLKPDEVTEDISLIRELTGQPPAPFRLRSD
Protein: Small ribosomal subunit protein bS18c (30S ribosomal protein S18, chloroplastic) (Q6ENF1)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS12c
- Large ribosomal subunit protein uL23m
- S5 DRBM domain-containing protein
- Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein
- Small ribosomal subunit protein bS16c
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS2c
- Small ribosomal subunit protein uS2c
- Large ribosomal subunit protein mL54
Sequence:
MYTSKQPFHKSKQTFHKSKQTFRKSKQTFRKFKQPFRKPKQPFRRRPRIGPGDRIDYRNMSLINRFISEQGKILSRRINRLTLKQQRLITLAIKQARILSFLPFRNYENEKQFQAQSISIITGPRPRKNRHIPPLTQKFNSNRNLRNSNQTLRNNNRNLSSDC
Protein: HSPB3 protein (Heat shock 27kDa protein 3) (Q6ICS9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK
Protein: Covalently-linked cell wall protein, putative (B9WLX0)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
Sequence:
MKFSTAALTFSFFAIVNSSVVTYSTEFGGNEEHKHDKYDCEIDTFDWKFALVVKEWKHHKDEKFCKDTDLDLVYEGDDGQLYHGCDGTYPYSKCKHCTNVFGGGDDDNKWDNKWKDDKGDDKWKDKKCDDKWDDKHKDDHCKDDNGKDGKCKDDDKCKDKKCDDKWDGNCKDDHGKDDKCKDDGKWDDKCKDKCDDKHKDDNCKDEKCDDKCKDDEKCHDHWKGDDKCDKHHCKYPYCEIHNTDCDLLITLCNGVLKDKRDATGEIAVNHQFQFDKPPQNDALHKKGFSIVHTEGTYYLALNHQIEFWHCKVDDKGLYKIYDKSIGDQCSKIELIVLKSDEKATNDDCDDDCKKKEKYD
Protein: NAD(P)H-dependent FMN reductase PA1204 (EC 1.-.-.-) (Q9I4D4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Has NAD(P)H-dependent FMN reductase activity.
Interaction partners:
- Putative quercetin 2,3-dioxygenase PA1205
- Probable hydrolase
- NAD
- NAD
- Probable NAD
- Probable NAD
- NADPH-dependent FMN reductase ArsH
- NADPH:quinone oxidoreductase MdaB
- Peroxiredoxin
- Bistable expression regulator, BexR
Sequence:
MSDDIKVLGISGSLRSGSYNSAALQEAIGLVPPGMSIELADISGIPLYNEDVYALGFPPAVERFREQIRAADALLFATPEYNYSMAGVLKNAIDWASRPPEQPFSGKPAAILGASAGRFGTARAQYHLRQTLVFLDVHPLNKPEVMISSAQNAFDAQGRLLDDKARELIQQQLQALQLWVRRLRG
Protein: Peptidyl-prolyl cis-trans isomerase 4 (PPIase 4) (EC 2.3.2.27) (EC 5.2.1.8) (Cyclophilin mog-6) (Cyclophilin-4) (Masculinization of germline protein 6) (RING-type E3 ubiquitin transferase isomerase 4) (Rotamase 4) (P52012)
Organism: Caenorhabditis elegans
Function: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q09928, ECO:0000250|UniProtKB:Q13356}.
Interaction partners:
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
- Pre-mRNA-splicing factor CWC25 homolog
- Pre-mRNA-processing factor 17
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor CWC22 homolog
- PWI domain-containing protein
- mRNA transport homolog 4
- Uncharacterized protein T27F2.1
- Pre-mRNA-splicing factor syf-2
- Tr-type G domain-containing protein
Sequence:
MGKKQHQKDKLYLTTSEWKSIGGHKDDTGTRLQRAQFKRLPINHCSLSLLPFEDPVCARSGEIFDLTAIVPYLKKHGKNPCTGKPLVAKDLIHLKFDKGEDGKFRCPVTFRTFTDHSHILAIATSGNVYSHEAVQELNLKRNHLKDLLTDVPFTRADIIDLQDPNHLEKFNMEQFLHVKLDLKTSEEIKKEKDAMKDPKFYIRRMNNACKSVLDQLDKEYVPKKSSTETDETADEINAAHYSQGKVAAGFTSTVMAPVTSNKAAVLDNDTVRYSRVKKNAFVRLVTNFGPLNLELFAPKVPKACENFITHCSNGYYNNTKFHRLIKNFMLQGGDPTGTGHGGESIWDKPFSDEFISGFSHDARGVLSMANKGSNTNGSQFFITFRPCKYLDRKHTIFGRLVGGQDTLTTIEKLETEEGTDVPMVSVVIMRAEVFVDPFEEAEKEVQAERAEILKKTSKDAASLANKKAKETATKPEAVGTGVGKYMKSAAAVNKRQGKMEDVPLEAAKKTKFARAGLGDFSKW
Protein: Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) (P0A884)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00008}.
Interaction partners:
- Dihydrofolate reductase
- Thymidine kinase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Serine hydroxymethyltransferase
- Dihydromonapterin reductase
- Thymidylate kinase
- Aminomethyltransferase
- dCTP deaminase
- 5,10-methylenetetrahydrofolate reductase
- Bifunctional protein FolD
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein: WPP domain-associated protein (O64584)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Accumulate in speckles of the cytoplasm belonging to the Golgi apparatus. {ECO:0000250}.
Interaction partners:
- WPP domain-containing protein 2
- WPP domain-containing protein 1
Sequence:
MEEEVVKSENGSLEFHDDTLSSSLQVNGVLKENENPDVDFLEDLDSYWEDINDRLTISRVVSDSIIRGMVTAIESDAAEKIAQKDLELSKIRETLLLYHVGSEENESSESRLIHDELTQGSSSSLKKKARKQLLMLVEELTNLREYIHINGSGATVDDSLGLDSSPHETRSKTVDKMLDSLKSILETVLKRKNDMELPSSWQQEHDFQKEIESAVVTSVLRSLKDEYEQRLLDQKAEFGGNRSLILGNIKEITGLRQELEAIRKSFLDHENGDEAGEVGDRKRVEQLHRKMSGSLNSVSSVWENGKHEESSTGLIPEHNETLRHMSPDEMINHFKIEMNKMKRDHDYKIQELTEQCFTFKRKYLNLTERGSFSFVGKDKELGALKKKIPFVISKLDKILMEDEKFVSEGKNDAGLKRQLDSLLLENRQLKDSLSDAAEKMSQLSQAEADHQELIRKLETDVEDSRNEASIYEDVYGCFVTEFVGQIKCTKQETDLEHSMLREAYELLLEDLARKEARKSKEDFEDSCVKSVMMEECCSVIYKEAVKEAHKKIVELNLHVTEKEGTLRSEMVDKERLKEEIHRLGCLVKEKENLVQTAENNLATERKKIEVVSQQINDLQSQVERQETEIQDKIEALSVVSARELEKVKGYETKISSLREELELARESLKEMKDEKRKTEEKLSETKAEKETLKKQLVSLDLVVPPQLIKGFDILEGLIAEKTQKTNSRLKNMQSQLSDLSHQINEVKGKASTYKQRLEKKCCDLKKAEAEVDLLGDEVETLLDLLEKIYIALDHYSPILKHYPGIIEILRLVRRELSGESKRPSG
Protein: RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (B0LPE5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Protein: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (J3KTF5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS
Protein: Tegument protein pp150 (Q6SW99)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Participates in the last steps of viral maturation and release. Associates with nuclear capsids prior to DNA encapsidation and later preserves the integrity of nucleocapsids through secondary envelopment at the assembly compartment. Interacts with host CCNA2 and thereby blocks the onset of lytic gene expression to promote establishment of a quiescent state of infection in undifferentiated cells.
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P08318}. Host cytoplasm {ECO:0000250|UniProtKB:P08318}. Host nucleus {ECO:0000250|UniProtKB:P08318}. Note=Found initially localized in the host nucleus, associated either with the nuclear membrane or with viral assembly regions, and later in the host cytoplasm. {ECO:0000250|UniProtKB:P08318}.
Interaction partners:
Sequence:
MSLQFIGLQRRDVVALVNFLRHLTQKPDVDLEAHPKILKKCGEKRLHRRTVLFNELMLWLGYYRELRFHNPDLSSVLEEFEVRCAAVARRGYTYPFGDRGKARDHLAVLDRTEFDTDVRHDAEIVERALVSAVILAKMSVRETLVTAIGQTEPIAFVHLKDTEVQRIEENLEGVRRNMFCAKPLDLNLDRHANTALVNAVNKLVYTGRLIMNVRRSWEELERKCLARIQERCKLLVKELRMCLSFDSNYCRNILKHAVENGDSADTLLELLIEDFDIYVDSFPQSAHTFLGARSPSLEFDDDANLLSLGGGSAFSSVPKKHVPTQPLDGWSWIASPWKGHKPFRFEAHGSLAPAAEAHAARSAAVGYYDEEEKRRERQKRVDDEVVQREKQQLKAWEERQQNLQQRQQQPPPPTRKPGASRRLFGSSADEDDDDDDDDEKNIFTPIKKPGTSGKGAASGGGVSSIFSGLLSSGSQKPTSGPLNIPQQQQRHAAFSLVSPQVTKASPGRVRRDSAWDVRPLTETRGDLFSGDEDSDSSDGYPPNRQDPRFTDTLVDITDTETSAKPPVTTAYKFEQPTLTFGAGVNVPAGAGAAILTPTPVNPSTAPAPAPTPTFAGTQTPVNGNSPWAPTAPLPGDMNPANWPRERAWALKNPHLAYNPFRMPTTSTASQNTVSTTPRRPSTPRAAVTQTASRDAADEVWALRDQTAESPVEDSEEEDDDSSDTGSVVSLGHTTPSSDYNNDVISPPSQTPEQSTPSRIRKAKLSSPMTTTSTSQKPVLGKRVATPHASARAQTVTSTPVQGRLEKQVSGTPSTVPATLLQPQPASSKTTSSRNVTSGAGTSSASSARQPSASASVLSPTEDDVVSPATSPLSMLSSASPSPAKSAPPSPVKGRGSRVGVPSLKPTLGGKAVVGRPPSVPVSGSAPGRLSGSSRAASTTPTYPAVTTVYPPSSTAKSSVSNAPPVASPSILKPGASAALQSRRSTGIAAVGSPVKSTTGMKTVAFDLSSPQKSGTGPQPGSAGMGGAKTPSDAVQNILQKIEKIKNTEE
Protein: Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) (Virion structural protein BVRF2) [Cleaved into: Assemblin (EC 3.4.21.97) (Protease) (Pr); Assembly protein (AP) (Capsid assembly protein)] (Q1HVC7)
Organism: Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Function: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.
Subcellular location: [Capsid scaffolding protein]: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04008}.; SUBCELLULAR LOCATION: [Assemblin]: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04008}.; SUBCELLULAR LOCATION: [Assembly protein]: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04008}.; SUBCELLULAR LOCATION: [Isoform pAP]: Host nucleus {ECO:0000250|UniProtKB:P03234}.
Interaction partners:
Sequence:
MVQAPSVYVCGFVERPDAPPKDACLHLDPLTVKSQLPLKKPLPLTVEHLPDAPVGSVFGLYQSRAGLFSAASITSGVFLSLLDSIYHDCDIAQSQRLPLPREPKLEALHAWLPSLSLASLHPDIPQTTADGGKLSFFDHVSICALGRRRGTTAVYGTDLAWVLKHFSDLEPSIAAQIENDANAAKRESGCPEDHPLPLTKLIAKAIDAGFLRNRVETLRQDRGVANIPAESYLKASDAPDLQKPDKALQSPPPASTDPDTMLSGNAGEGATACGGSAAAGQDLISVPRNTFMTLLQTNLDNKPPRQTPLPYAAPLPPFSHQAIATAPSYGPGAGAVAPAGGYFTSPGGYYAGPAGGDPGAFLAMDAHTYHPHPHPPPAYFGLPGLFGPPPPVPPYYGSHLRADYVPAPSRSNKRKRDPEEDEEGGGLFPGEDATLYRKDIAGLSKSVNELQHTLQALRRETLSYGHTGVGYCPQQGPCYTHPGPYGFQPHQSYEVPRYVPHPPPPPTSHQAAQAQPPPPGTQAPEAHCVAESTIPEAGAAGNSGPREDTNPQQPTTEGHHRGKKLVQASASGVAQSKEPTTPKAKSVSAHLKSIFCEELLNKRVA
Protein: Small ribosomal subunit protein eS24 (40S ribosomal protein S24) (P62850)
Organism: Rattus norvegicus (Rat)
Function: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62847}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62847}.
Interaction partners:
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS7
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS10
Sequence:
MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE
Protein: NOTCH1 protein (Q6IAD4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSNMRCVDCGTCLGHTRRHPTLFWGKTLPGLTPVAAPAPQPAQCPPGSEEDAPATQPGPQLAGPDPPWAPVFCRRLARAGHIELCNAVGCVLWSCPRSPGRGHAVGQGLEGGGGCPWATPPSLGGADFCNTKYSLWQKKCL
Protein: Glycogen synthase kinase-3 (GSK-3) (EC 2.7.11.26) (P51136)
Organism: Dictyostelium discoideum (Social amoeba)
Function: During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation.
Interaction partners:
- Heat shock factor-type DNA-binding domain-containing protein
- Inositol monophosphatase
Sequence:
MSSKDQILEKDKKETDDNGNKKTTTTTSSSSSSSSSSKPRSNKFDKVIIKSNGVCYITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQRYKNRELQIMKMLNHINIVSLKNSFYTSDNDEVYLNLVLEYVPDTVYRVSRHYSMSKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILIKGETNVSYICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGENGIDQLVEIIKVLGTPTKEQIHAMNPYYTSFKFPEIKANPWPRVFKAKDVPAESIDLISKILLYDPSSRLKPVEICAHPFFDELRDPKTCLPDGKPLPPLFNFTIAEQTSIGPKLAKTLIPSHAMNQIELPSPLFPNLAISSSNQSSSSNSNANVSSNLNSHSASPSTTSSSSSTPNSIPVQSPSTTNTTSSTTNNTTTTTTTTTTSNH
Protein: 39S ribosomal protein L28, mitochondrial (Q586A2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- KOW domain-containing protein
- Large ribosomal subunit protein uL29m
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Large ribosomal subunit protein mL43
- LIM zinc-binding domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
Sequence:
MLRNTDVRLFSTFALNPETSVAPHGPPRGLVNRYVSMGLPPWAAWCNKVNRYSLYRMSGVTQRSFLPKPPQEMDVIWLNERVRERVRTSRQVQNVYRQLKYPYVKTGIHYSDVLDHWVQVPMVEAAMFEVEKDGGFDNFILKRSGPELRSTYGERIRRHILVRQKEIQKNFVLQKQAQMLVESMEKEILPMEDGKKVEEVLEKYGIDKEQLLRDIARAAVAKKQQLASAVPQPSHVEVSTN
Protein: Uncharacterized protein, isoform P (M9PHY1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAALQRKLVHKQFNSPMGLYSQENVKATLNRELKAFGGEGIEVDDQITKPLNLANSAVLRAVEEEEQQAKCGYKRVAWPPASEERIIREFTPQPQTQSPAPGAGGYYPQAHAPTAAAAAPPQL
Protein: Delta-1-pyrroline-5-carboxylate synthase 1 (OsP5CS1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] (O04226)
Organism: Oryza sativa subsp. japonica (Rice)
Function: P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants. Involved in abiotic stress tolerance.
Interaction partners:
- Delta-1-pyrroline-5-carboxylate synthase 2
- Ornithine aminotransferase, mitochondrial
- Proline dehydrogenase
- Os01g0221900 protein
- Os05g0536400 protein
- Succinate-semialdehyde dehydrogenase, mitochondrial
- Ferredoxin-dependent glutamate synthase, chloroplastic
- Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial
- Os03g0555000 protein
- Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic
Sequence:
MASVDPSRSFVRDVKRVIIKVGTAVVSRQDGRLALGRVGALCEQVKELNSLGYEVILVTSGAVGVGRQRLRYRKLVNSSFADLQKPQMELDGKACAAVGQSGLMALYDMLFNQLDVSSSQLLVTDSDFENPKFREQLTETVESLLDLKVIPIFNENDAISTRKAPYEDSSGIFWDNDSLAGLLALELKADLLILLSDVDGLYSGPPSEPSSKIIHTYIKEKHQQEITFGDKSRVGRGGMTAKVKAAVLASNSGTPVVITSGFENRSILKVLHGEKIGTLFHKNANLWESSKDVSTREMAVAARDCSRHLQNLSSEERKKILLDVADALEANEDLIRSENEADVAAAQVAGYEKPLVARLTIKPGKIASLAKSIRTLANMEDPINQILKKTEVADDLVLEKTSCPLGVLLIVFESRPDALVQIASLAIRSGNGLLLKGGKEAIRSNTILHKVITDAIPRNVGEKLIGLVTTRDEIADLLKLDDVIDLVIPRGSNKLVSQIKASTKIPVLGHADGICHVYIDKSADMDMAKHIVMDAKIDYPAACNAMETLLVHKDLMKSPGLDDILVALKTEGVNIYGGPIAHKALGFPKAVSFHHEYSSMACTVEFVDDVQSAIDHIHRYGSAHTDCIVTTDDKVAETFLRRVDSAAVFHNASTRFSDGARFGLGAEVGISTGRIHARGPVGVEGLLTTRWILRGRGQVVNGDKDVVYTHKSLPLQ
Protein: Lactose-binding lectin l-2 (Ajl-2) (Q90WJ8)
Organism: Anguilla japonica (Japanese eel)
Function: Involved in host defense at the body surface. Causes agglutination and suppresses the growth of the Gram-negative bacterium E.coli K12. Possesses calcium-independent hemagglutinating activity.
Subcellular location: Secreted {ECO:0000269|PubMed:11959866}.
Interaction partners:
Sequence:
MVSFKLPAFLCVAVLSSMALVSHGAVLGLCEGACPEGWVEHKNRCYLHVAEKKTWLDAELNCLHHGGNLASEHSEDEHQFLKDLHKGSDDPFWIGLSAVHEGRSWLWSDGTSASAEGDFSMWNPGEPNDAGGKEDCVHDNYGGQKHWNDIKCDLLFPSICVLRMVE
Protein: E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING-type E3 ubiquitin transferase TRIM63) (Tripartite motif-containing protein 63) (Q91Z63)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11927605}. Note=Colocalizes with TNNI3 in myocytes. Localizes to the M- and Z-lines in skeletal muscle (By similarity). {ECO:0000250}.
Interaction partners:
- Titin
- F-box only protein 32
- Uncharacterized protein.
- Growth/differentiation factor 8
- Myosin-4
- Next to BRCA1 gene 1 protein
- E3 ubiquitin-protein ligase RING1
- Myogenin
- Nebulin
- Myoblast determination protein 1
Sequence:
MDYKSGLIPDGNAMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWTNRGGSVSMSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSLCKVFGAHQACEVAPLQSIFQGQKTELSNCISMLVAGNDRVQTIISQLEDSCRVTKENSHQVKEELSHKFDALYAILDEKKSELLQRITQEQEEKLDFIEALILQYREQLEKSTKLVETAIQSLDEPGGATFLLSAKPLIKSIVEASKGCQLGKTEQGFENMDYFTLNLEHIAEALRAIDFGTDEEEEFTEEEEEEDQEEGVSTEGHQ