wanglab/gogpt-training-data huggingface dataset:
Protein: Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) (Q86V20)
Organism: Homo sapiens (Human)
Function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Subcellular location: Nucleus {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}. Chromosome {ECO:0000269|PubMed:29656893, ECO:0000305|PubMed:29789392}. Note=Localizes to nuclear foci in response to DNA damage. {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}.
Interaction partners:
- Shieldin complex subunit 3
- Mitotic spindle assembly checkpoint protein MAD2B
- Shieldin complex subunit 1
- TP53-binding protein 1
- DNA polymerase zeta catalytic subunit
Sequence:
MSGGSQVHIFWGAPIAPLKITVSEDTASLMSVADPWKKIQLLYSQHSLYLKDEKQHKNLENYKVPESIGSPDLSGHFLANCMNRHVHVKDDFVRSVSETQNIESQKIHSSRLSDITSSNMQICGFKSTVPHFTEEEKYQKLLSENKIRDEQPKHQPDICGKNFNTNLFQLGHKCAAVLDLVCSTEKINIGPEVVQRECVPTEYHEIQNQCLGLFSSNAVDKSRSEAAVRKVSDLKISTDTEFLSIITSSQVAFLAQKKDKRRSPVNKGNVNMETEPKASYGEIRIPEENSIQLDGFTEAYESGQNQAYSLELFSPVCPKTENSRIHINSDKGLEEHTGSQELFSSEDELPPNEIRIELCSSGILCSQLNTFHKSAIKRSCTSEDKVGQSEALSRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKSIKKTSLIKNCDSKSQKYNCLVMVLSPCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLTDVVIHEDQWIGETVLQSTFSSQLLNLGSYSSIQPEEYSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGVVLIKAQISELAFPITASQKIALNAHSSLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLAVSAEPCVLKIQSLFVLDENSYPLQQDFSLLDFYPDIVKHGANARL
Protein: Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) (P58200)
Organism: Rattus norvegicus (Rat)
Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9UEU0}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UEU0}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9UEU0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000255}.
Interaction partners:
- Syntaxin-8
- Syntaxin-7
- Vesicle-associated membrane protein 8
- Syntaxin-7
- Syntaxin-6
- Vesicle-associated membrane protein 7
- Syntaxin-5
- Synaptobrevin homolog YKT6
- Syntaxin-16
- Alpha-soluble NSF attachment protein
Sequence:
MATSAASSEHFEKLHEIFRGLLEDLQGVPERLLGTAGTEEKKKLVRDFDEKQQEANETLAEMEEELRYAPLTFRNSMMSKLRNYRKDLAKLHREVRSTPLTATPGGRGDLKFGTYTLENEHLNRLQSQRALLLQGTESLNRATQSIERSHRIAAETDQIGSEIIEELGEQRDQLERTKSRLVNTNENLSKSRKILRSMSRKVITNKLLLSVIIVLELAILVGLVYYKFFRHH
Protein: Fgl2 protein (Q32Q89)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
LPGWLWLSSAVLAACRAAEKHNLTEGLEDASAQAACPARLEGSGRCEGSQCPFQLTLPTLTLQLPQQFGSMEEVLKEVRTLQEAVDSLKKSCQDCKLQADEHPDPGGNGAETAEDNRVQELESQVNKLSSELKNAKEEIQGLQGRLESLQLVNMNNIENYVDNKVANLTSVVNSLDSKCFKCPSQEHNQPNPVQHLIYKDCSDYYVLGKRSSGTYRVTPDHRNSSFEVYCDMETTGGGWTVLQARLDGSTNFTRGWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYAVYDQFYVANEFLKYRLHLGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQRYKGVRNGIFWGTWPGVSQAHPGGYKFSFKKAKMMIRPKSFKP
Protein: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) (P11177)
Organism: Homo sapiens (Human)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Pyruvate dehydrogenase protein X component, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha
- [Pyruvate dehydrogenase
- Pyruvate kinase PKM
- Glucose-6-phosphate isomerase
Sequence:
MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
Protein: Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic (ENR) (EC 1.3.1.9) (NADH-dependent enoyl-ACP reductase 1) (Protein MOSAIC DEATH 1) (Q9SLA8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NAD-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Catalyzes the last reduction step in the de novo synthesis cycle of fatty acids. Involved in the elongation cycle of fatty acids which are used in lipid metabolism. Required for normal plant growth.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- EMBRYO DEFECTIVE 3147
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic
- Palmitoyl-acyl carrier protein thioesterase, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 2, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 7, chloroplastic
Sequence:
MAATAASSLQIATRRPSMSSPSKILKAGTYIVGANPGNASWDKLSCTRQLSNLGCLRNHSAVPTCKRPFSFSTRAMSESSENKAPSGLPIDLRGKRAFIAGIADDNGYGWAIAKSLAAAGAEILVGTWVPALNIFETSLRRGKFDQSRVLPDGSLMEIKKVYALDAVFDNPEDVPEDVKTNKRYAGSSNWTVQEAAECVKKDFGSIDILVHSLANGPEVSKPLLETSRKGYLAAISASSYSFVSLLRHFLPIMNPGGASISLTYIASERIIPGYGGGMSSAKAALESDTRVLAYEAGRKSNIRVNTISAGPLGSRAAKAIGFIDTMIEYSYNNGPIQKTLTADEVGNAAAFLASPLASAITGATIYVDNGLNAMGVALDSPVFKDLNSKN
Protein: Formin-like protein (DUF1421) (Putative proline-rich protein) (Q8VZR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3G29180 protein)
- At1g44770
- At3g26990
- Amino acid transporter AVT6D
- At5g09670
- At1g05410/T25N20_5)
- At3g50040
- At1g73210
- At5g08360
- Uncharacterized protein
Sequence:
MASGSSGRVNSGSKGFDFGSDDILCSYDDYTNQDSSNGPHSDPAIAASNSNKEFHKTRMARSSVFPTSSYSPPEDSLSQDITDTVERTMKMYADNMMRFLEGLSSRLSQLELYCYNLDKTIGEMRSELTHAHEDADVKLRSLDKHLQEVHRSVQILRDKQELADTQKELAKLQLVQKESSSSSHSQHGEDRVATPVPEPKKSENTSDAHNQQLALALPHQIAPQPQVQPQPQPQQHQYYMPPPPTQLQNTPAPVPVSTPPSQLQAPPAQSQFMPPPPAPSHPSSAQTQSFPQYQQNWPPQPQARPQSSGGYPTYSPAPPGNQPPVESLPSSMQMQSPYSGPPQQSMQAYGYGAAPPPQAPPQQTKMSYSPQTGDGYLPSGPPPPSGYANAMYEGGRMQYPPPQPQQQQQQAHYLQGPQGGGYSPQPHQAGGGNIGAPPVLRSKYGELIEKLVSMGFRGDHVMAVIQRMEESGQPIDFNTLLDRLSGQSSGGPPRGW
Protein: Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) (Q14254)
Organism: Homo sapiens (Human)
Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Membrane-associated protein of caveolae.
Interaction partners:
- Flotillin-1
- Caveolin-1
- Cadherin-1
- Sodium-dependent dopamine transporter
- Sorbin and SH3 domain-containing protein 1
- E3 ubiquitin-protein ligase CBL
- Stomatin
- Prostate tumor-overexpressed gene 1 protein
- CD81 antigen
- Coronin-1C
Sequence:
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
Protein: Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) (ZnT-3) (P97441)
Organism: Mus musculus (Mouse)
Function: Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:9356509, ECO:0000305|PubMed:21998198, ECO:0000305|PubMed:9990090}; Multi-pass membrane protein {ECO:0000305|PubMed:21998198}. Synapse, synaptosome {ECO:0000269|PubMed:21998198}. Late endosome membrane {ECO:0000250|UniProtKB:Q99726}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q99726}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- AP-3 complex subunit beta-1
- Zinc transporter 6
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP1
- Zinc transporter SLC39A7
- AP-3 complex subunit delta-1
- Zinc transporter ZIP6
- Zinc transporter ZIP12
- Zinc transporter ZIP13
- Zinc transporter ZIP5
Sequence:
MEPSLATGGSETTRLVSARDRSSAGGGLRLKSLFTEPSEPLPEEPKLEGMAFHHCHKDPVPQSGLSPERVQARRQLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLAFLRLLHSDYHIEAGAMLLTASIAVCANLLMAFVLHQTGAPHSHGSTGAEYAPLEEGHGYPMSLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKVADPISTFLFSICALGSTAPTLRDVLLVLMEGAPRSVEFEPVRDTLLSVPGVRATHDLHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRCQEPSQA
Protein: Uncharacterized protein (Q382B3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYECVVKPKGTLLPFLPICRLIRTVVFVLFATICYIGNVRQDKVPLLRHLLSYHFPLSPSGSSRSAVPNIFYKANMTSLNGSKSSAYGTLKFTNRMGTPLPSPSKKLKSAPAATGVPPPPFTLAVGNRTSSTSPRTPVAMGETSVVSSPNGYNPPLPTISDAASGQGTGNGTTNIDGVAYNHSRRRRQRGPTGKASTDNNNTAEVAASSPGAQPSCNSYDSGGTYNSFWSPRATNADVLGWPKVEDHQVPTDDVQLGSHTRRYGGSLGAVPRLSVKVLGMSPLHANLLVARPFVRVWLLDGHTGRNLIKTEFLRSSFGVTHPVDLRCRHTRAPWWGAELLFCVHSSLIEEPSVDPLLLMEVLESGEEAINGVPVPRDGFYPVCWGFLKLRSANGRMNMGKRLNIQMFPFPGRVSVLTRLMQQLPSFLFRSRRGVDGDDIGPLHSQETTEYEMCCASDAVKGNGNTSTPPAIFYTYKRAQNRQVPYAATLLISLRWEDDISYVPSEAHILPSEECFLDQMPVSQDHKPRSTARSAYSGRPWSTEDKSARYGINTTALGRSYLRNEDERVVPPPLVVQSTQIVGKVTCITFAGVESLMALGVTDGADYLIQLRHALVCGAPIFGVCRGHAGHIHSVTFRRDSQLLLSSSSDKTVRVWRLDNFPSATISYQVMIVPCLCTLPHSFPLYDSVFFESVIVTCGFDPRLFVWNYKEFDNQEVETTIEREQYNHSGAAWQPGRVGSVPLSSTNFNITTAGCGVGQVVYETTGDDGVVVRALSASDRGRLWSVDTLGNVLIWHSEDGVTLDGSTQWRIRTRYRFKCPGATKVEVHGDRALVTCEKHPVAYLIDVMSHQLLHTIYMHQKPYIPVVTLLPDGEAFVACTCDGRLLYWECFSGTLCTPLSGYGAIRTHGSPRRIVWSPNQQLAAVLGSWNHSSLARRESHSSFMALTIVGAPREEGNVLLRTDAHSEAKFRSRLISGEASPPLTRVSSAGTSESPLWATSGQPQSSRPVGAMPSSIFESKSSRIDNIVAVWKQLTSRHRCRRSEEPPFTANSGIDKYVAENV
Protein: Zinc finger protein 266 (Zinc finger protein HZF1) (Q14584)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MLENYKNLATVGYQLFKPSLISWLEQEESRTVQRGDFQASEWKVQLKTKELALQQDVLGEPTSSGIQMIGSHNGGEVSDVKQCGDVSSEHSCLKTHVRTQNSENTFECYLYGVDFLTLHKKTSTGEQRSVFSQCGKAFSLNPDVVCQRTCTGEKAFDCSDSGKSFINHSHLQGHLRTHNGESLHEWKECGRGFIHSTDLAVRIQTHRSEKPYKCKECGKGFRYSAYLNIHMGTHTGDNPYECKECGKAFTRSCQLTQHRKTHTGEKPYKCKDCGRAFTVSSCLSQHMKIHVGEKPYECKECGIAFTRSSQLTEHLKTHTAKDPFECKICGKSFRNSSCLSDHFRIHTGIKPYKCKDCGKAFTQNSDLTKHARTHSGERPYECKECGKAFARSSRLSEHTRTHTGEKPFECVKCGKAFAISSNLSGHLRIHTGEKPFECLECGKAFTHSSSLNNHMRTHSAKKPFTCMECGKAFKFPTCVNLHMRIHTGEKPYKCKQCGKSFSYSNSFQLHERTHTGEKPYECKECGKAFSSSSSFRNHERRHADERLSA
Protein: PBX homeobox 1 (F7EV88)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISDMSRTY
Protein: Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) (Q8C419)
Organism: Mus musculus (Mouse)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22689652, ECO:0000269|PubMed:25792749, ECO:0000269|PubMed:30546127}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T848}. Postsynaptic cell membrane {ECO:0000269|PubMed:30290982, ECO:0000269|PubMed:36979415}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T848}. Presynaptic cell membrane {ECO:0000269|PubMed:36979415}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T848}. Nucleus {ECO:0000250|UniProtKB:Q5T848}. Note=Mainly localizes to the postsynaptic membrane, with a small portion to the presynaptic membrane (PubMed:36979415). Trafficks between the nucleus and the cell membrane; it is unclear how a multi-pass membrane protein can traffick between the nucleus and the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q5T848, ECO:0000269|PubMed:36979415}.
Interaction partners:
- Regulator of G-protein signaling 7
- Guanine nucleotide-binding protein subunit beta-5
- G-protein coupled receptor family C group 6 member A
- Regulator of G-protein signaling 9
Sequence:
MGAMAYSLLFCLLLAHLGLGEVGASLDPPGRPDSPRERTPRGKQHGQQLPRASAPDPSIPWSRSTDGTILAQKLAEEVPVDVASYLYTGDFHQLKRANCSGRYELAGLPGKSPSLASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQALVRSLLEGEPSISRAAITFSTESLSTPAPQVFLQATREESRILLQDLSSSAHHLANATLETEWFHGLRRKWRPHLHRRGSNQGPRGLGHSWRRRDGLGGDRSHVKWSPPYLECENGSYKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDISLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYQCICKAGFYHPRVFSVNNFQRRGPDHHFSGSTKDVSEETHVCLPCREGCPFCADDRPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSDHLTFNMCLIDRWDYMTAVAEFLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELIITAIFHTIRFVLASRLQPDWMLMLYFAHAHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGTDHSAAKGTGLVRKNPTESSGNTGRPKEESLKNRVFSLKKSHSTYDHVRDQTVESSSLPMESQEEEATENSTLESLSSKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKPGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTLVMEDRAKSQKPKDRETIRKYSNSDNVETIPNSGHMEEPRKPQKSGIMKQQRVSLPTANPDVSSGITQIKDNFDIGEVCPWEVYDLTPGPMPSEPKAQKHVSIAASEVEQNPASFLKEKSYHKSKATEGLYQANHKSIDKTEVCPWEIHSQSLLEDENRLISKTPVLPGRAREENGSQLYTTNMCAGQYEELPHKVVAPKVENENLNQMGDQEKQTSSSVDIIPGSCNSSNNSHQPLTSRAEVCPWEFEPLEQPNAERSVTLPASSALSANKIPGPQK
Protein: Inward rectifier potassium channel 16 (BIR9) (Inward rectifier K(+) channel Kir5.1) (Potassium channel, inwardly rectifying subfamily J member 16) (P52191)
Organism: Rattus norvegicus (Rat)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity). In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9NPI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPI9}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NPI9}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO:0000250|UniProtKB:Q9NPI9}.
Interaction partners:
- ATP-sensitive inward rectifier potassium channel 10
- ATP-sensitive inward rectifier potassium channel 15
Sequence:
MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVVFSLSYILSWLIFGSIFWLIALHHGDLLSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCTSDTNTRRRSFSAVAMVSSCENPEETSLSPQDECKEVPYQKALLTLNRISMESQM
Protein: Pre-mRNA-splicing factor cdc5 (Cell division control protein 5) (P39964)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in mRNA splicing and cell cycle control.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:10409726}.
Interaction partners:
- Pre-mRNA-splicing factor cwf4
- Pre-mRNA-splicing factor cwf18
- Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16
- U2 snRNP component prp10
- Pre-mRNA-splicing factor cwf26
- Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28
- Pre-mRNA-splicing factor cwf22
- Splicing factor YJU2
- Pre-mRNA-splicing factor syf2
- Pre-mRNA-splicing factor cwf12
Sequence:
MVVLKGGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQWRTIAPIVGRTATQCLERYQKLLDDLEAKENEQLGLISGEGAEAAAPVNDPNSRLRFGEAEPNLETLPALPDAIDMDEDEKEMLSEARARLANTQGKKAKRKDREKQLELTRRLSHLQKRRELKAAGINIKLFRRKKNEMDYNASIPFEKKPAIGFYDTSEEDRQNFREKREADQKIIENGIRNNEMESEGRKFGHFEKPKPIDRVKKPNKDAQEEKMRRLAEAEQMSKRRKLNLPSPTVSQDELDKVVKLGFAGDRARAMTDTTPDANYSTNLLGKYTQIERATPLRTPISGELEGREDSVTIEVRNQLMRNREQSSLLGQESIPLQPGGTGYTGVTPSHAANGSALAAPQATPFRTPRDTFSINAAAERAGRLASERENKIRLKALRELLAKLPKPKNDYELMEPRFADETDVEATVGVLEEDATDRERRIQERIAEKERLAKARRSQVIQRDLIRPSVTQPEKWKRSLENEDPTANVLLKEMIALISSDAINYPFGNSKVKGTANKVPDLSNEEIERCRLLLKKEIGQLESDDYIQFEKEFLETYSALHNTSSLLPGLVIYEEDDEDVEAAEKFYTNDIQRDLAKKALECNKLENRVYDLVRSSYEQRNFLIKKISHAWKALQTERKNLTCYEFLYNQERLALPNRLEAAEIELSKMQQIEAYAQQDYARVTGQN
Protein: Uncharacterized protein (Q57ZT7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNSDPNASVTRLNLSESVAALPTSGGSSMPSWADTSLLVNAYSTQTGMGNDGKPPVVHSLKTDIAPHYSGRLHCVQREPVAGASNASNLTRTERNYHAEISVLWRLLHSERAALQATERRVFEEQERGMRGIISTEANYGAKLLHAFLLESLDLQTTTDDWTPPVREKKDRCPRIHMERAKARSAGKKTPLDSNQSAPPDSSSPSVPSYEQLREENRLLRAEVERYKAIDTEDRLELNKMHRSMRATITQLVHECSKLHAELSRHEKAPGAAPVAVVQSPCLGESDSAFAEVSYSWANHASHHTK
Protein: Emb|CAB62594.1 (Plant calmodulin-binding protein-like protein) (Q9FLZ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDEDIAKPFVTPENMMNKEDGLNPGGDSTGKAMTSKPKEKKIPHYLRASTGSCHDLCKYGKRQIPVEKPWRSSTKKIFKKSLDDNLNETLKPGSSKMKKKVREVEKNEGTDDSFEVIKREVVKYQASGVSSGMRKPEVLIISSCDETPVKQIKKKTTLSSKLKPSPDLGSRSSENVDALKPKVLKKSYSALTTSKPKVNHEKVVASPVLKPKMGKRNDGKDEDGKVKKGTVSSRVASKKAPVTPRASLSPRLSVRLAGSSSLRKSQSLKAASSSSRQNQKPRPVNRTDEFNKQLDDYPVEEKTLHVVEMETTNNVVSENDQNQQGFVEPFLPPLPPTQSTPKDDECTVSETEEYEYTSGSNEAESEEEEIGLSNGEKKPRAARKEGDSADEAARKLRFRRGTIVDPDTVGEKARKLKFRRGRGLGEDKAQDAQVRRSFKKREDIREEEVNEDGEKVVLRHQDVQEKDAQGLFNNVIEETASKLVEARKSKVKALVGAFETVISLQES
Protein: Microsomal triglyceride transfer protein large subunit (E9PBP6)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
Protein: Odorant receptor 23a (P81912)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 43a
- Odorant receptor 47b
- Odorant receptor 88a
- Putative odorant receptor 83c
- Putative odorant receptor 98b
- Putative odorant receptor 92a
- Odorant receptor 65a
- Odorant receptor 47a
- Prohibitin
- Odorant receptor 56a
Sequence:
MKLSETLKIDYFRVQLNAWRICGALDLSEGRYWSWSMLLCILVYLPTPMLLRGVYSFEDPVENNFSLSLTVTSLSNLMKFCMYVAQLTKMVEVQSLIGQLDARVSGESQSERHRNMTEHLLRMSKLFQITYAVVFIIAAVPFVFETELSLPMPMWFPFDWKNSMVAYIGALVFQEIGYVFQIMQCFAADSFPPLVLYLISEQCQLLILRISEIGYGYKTLEENEQDLVNCIRDQNALYRLLDVTKSLVSYPMMVQFMVIGINIAITLFVLIFYVETLYDRIYYLCFLLGITVQTYPLCYYGTMVQESFAELHYAVFCSNWVDQSASYRGHMLILAERTKRMQLLLAGNLVPIHLSTYVACWKGAYSFFTLMADRDGLGS
Protein: Hyperkinetic, isoform M (M9PHI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Potassium voltage-gated channel protein Shaker
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup107
- Protein SEC13 homolog
- GH13213p
- Nucleoporin seh1
- Potassium voltage-gated channel protein eag
- RE02508p
- Nuclear pore complex protein Nup75
- Fondue, isoform B
Sequence:
MSMALCNLNGDGSAAQSTSQSQSQSPAATAAAAPLLPHSHSHTLQPESTPLLLGHEQSGSAAPEGSGGGDVTDGAVTSIEMPTVVADDAGVPPLPLPLPQSTPQPLLMALPANLNFITGPTTQQLMIGNGAMGVIPSTNDSNNNNNNNNNVDNTSDESNPVTIYRCRAPIASLDCMEEFSRSISLGSNPALPLRHGSTPTPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAHSETEIGKILQRAGWKRTAYVITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPMEVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERILENKPVRPPMISTLALRXQSACPQGPLSLSGGGPCGADSPKHEDEAFIEEVDAAKDAAKQGFCLIQXQKESLDNDNKFLKVISSKTSLSSNTMTTTISKQEQQQQQQQQQQQQHLQPQQYVQLQQQHLMASGSTSDSAAAVPIAAELQFDSLNNNNNNNNNNTNGSPEQALPTSDERQKRRSLLNFKSLDFHLKSLYSGLRSNSGTTPPSQPNSSVPAVDQPQRRMPYLRVESVDPEEPRGSVLPGHSPSFLSPYSGVGGGAGSLQLPSNDGGTIRRSSTSDIVNCRRGGGAGGSGGGAASAQDSRRPSTSDLLRKARERKGSEARMGRSVSHSGLTRGGPGGGGGGLGGRRTSMAF