wanglab/gogpt-training-data huggingface dataset:
Protein: CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) (Q9H668)
Organism: Homo sapiens (Human)
Function: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication.
Subcellular location: Nucleus {ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19648609, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22763445}.
Interaction partners:
- CST complex subunit TEN1
- CST complex subunit CTC1
- Replication protein A 70 kDa DNA-binding subunit
- Replication protein A 14 kDa subunit
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 12
Sequence:
MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVDDPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSASSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
Protein: Forkhead box protein L2 (Q2TVT7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MMASYPEPEDTAGTLLAPESGRAVKEAEASPPSPGKGGGTTPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGSGGAAGGCGVPGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYSRVQSMALPPGVVNSYNGLGGPPAAPPPPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL
Protein: diguanylate cyclase (EC 2.7.7.65) (A0A0H2X9F2)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Interaction partners:
Sequence:
MIFEQARELAMLRSLRELQDVAEARRHADESENRMRHLAEQASRDALTGVFNRHQLGTALAHEFELATRQAWPLSIAFIDLDDFKRVNDAHGHLVGDEVLRNFAQTLQRMVRTSDLVARYGGEEFLVILPNTTAEAALMVIERILAETARTPMAQLPGGPLHITFSAGLATHGGGDRQFESIEHLLQAADTTLYRSKHRGRNRVTAYDATEVPAQPTPRAH
Protein: Protein FAM193B (Q96PV7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21177767}. Nucleus {ECO:0000269|PubMed:21177767}. Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm.
Interaction partners:
Sequence:
MTRRRSRPSGGAGRRERARAAGPQKPQAPEPPPPPSLEAGAGAGPPEAPAEPDHDGPREDDEPNLVPGPQVPPASSQPVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGDDSHSSSSSSSSSSSSSSSSCPGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGSSLGSPPTIPGEAFPVSEHHQHSDLTAPPNSPTGHHPQPASLIPSHPSSFGSPPHPHLLPTTPAAPFPAQASECPVAAATAPHTPGPCQSSHLPSTSMPLLKMPPPFSGCSHPCSGHCGGHCSGPLLPPPSSQPLPSTHRDPGCKGHKFAHSGLACQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAPPAAPTSRNYTEIREKLRSRLTRRKEELPMKGGTLGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRVSGSREPRPARERLLEWPDRELDRVNSFLSSRLQEIKNTVKDSIRASFSVCELSMDSNGFSKEGAAEPEPQSLPPSNLSGSSEQQPDINLDLSPLTLGSPQNHTLQAPGEPAPPWAEMRGPHPPWTEVRGPPPGIVPENGLVRRLNTVPNLSRVIWVKTPKPGYPSSEEPSSKEVPSCKQELPEPVSSGGKPQKGKRQGSQAKKSEASPAPRPPASLEVPSAKGQVAGPKQPGRVLELPKVGSCAEAGEGSRGSRPGPGWAGSPKTEKEKGSSWRNWPGEAKARPQEQESVQPSGPARPQSLPQGKGRSRRSRNKQEKPASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ
Protein: Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (Q3ULB5)
Organism: Mus musculus (Mouse)
Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cotranslocates into nucleus with AR in response to androgen induction. {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- Rho guanine nucleotide exchange factor 7
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 3
- SH2/SH3 adapter protein Nck1
- Cytoplasmic protein NCK2
- Rho guanine nucleotide exchange factor 6
- Roundabout homolog 2
- Dual specificity mitogen-activated protein kinase kinase 1
- Roundabout homolog 1
Sequence:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSEHTDPHGLYLSCNGGTPAGHRQVPWPEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQQLGACLQSSPPGTSPPMATGRRGVKVAKHSSEEARPQSCLVGSAIGRPGGEGSPSPKNQESSLKHRLFRSMFLSTPATGAASSSKPVPLPQNKPNSAFRPPQKDSSSNLVAKAQSLPSEQPMGTFSPLTTSDTSSPQKSLRTAPAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGIVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
Protein: Tropomyosin 3 (Tropomyosin alpha-3 chain isoform 2) (Q803M1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAGSNSIDAVKRKIKVLQQQADEAEERAEILQRQVEEEKRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIVEGELERTEERAELAESHVKQMEEELRALDQTLKTLQASEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEEKLRDAKEENIKIHATLDQTLSELNSF
Protein: Inner nuclear membrane protein HEH2 (Helix-extension-helix domain-containing protein 2) (Q03281)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16929305}; Single-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16929305}. Note=Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle.
Interaction partners:
- Importin subunit alpha
- Uncharacterized protein YJL049W
- Nucleoporin POM152
- Leucine aminopeptidase 2
- Nuclear membrane organization protein APQ12
- Mannitol dehydrogenase DSF1
- Spindle pole body assembly component MPS3
- Nucleoporin NUP170
- Nucleoporin NUP188
- Nucleoporin NUP116/NSP116
Sequence:
MDHRNLDPKTLKVSQLRRVLVENDVAFPANARKPVLVKLFEEKVRQRLQSSPEASKVRTSIQKVVKSGAKNADRKKTLKSKKLESSSSESKTVKDENVETNKRKREQISTDNEAKMQIQEEKSPKKKRKKRSSKANKPPESPPQSKSDGKATSADLTSELETVEELHKKDSSDDKPRVKELPKPELPNLKVSNEFLAQLNKELASAATENYDHSIKSTDLSSIRIETEEPVGPSTGAETRNESEVMENINLEVQPEVKEAKEELTKISETFDNQDEEDTSRLSSKKNIRSPKGRTRHFIANKTKRGIDIMKPFIAHLFIWLWNGAIFLSIICPILFGLWYREQRIQVGYCGHEKPLKSLAISAFPQTERVDSVLQAYRPNCLECPEHGICSSFMNVECEPGYEPKSSILETYGIIPFPKYCAKDESKEKEVDELVWKVNEYLKKKNAQHECGEGENLFESGETETKLYDIFSHSRPSWESQREFNDHWKNVLEILKKKDDIIWLPLDFETNGKREKSKSNNTNYIYRSTSKKWVTLQCHLEGDIQEYITKYGGSLFITLGVLFLIKKIQSTLDNYVQGEQIIEKLVKEAIDKLKDVKKNKGEEPFLTTVQLRATLLSDIPNIKEQNNLWAQTKEKIMKEQSENIELYLLEENGEIMTCWEWKE
Protein: C2H2-type domain-containing protein (H2KYB2)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSISGEDNEIILNASLSNSPDQLDVFEESRRNFLESINATVSMTSNGSKNGIEDIANRLKQNGNTTSTSLTSNSGLYPTDPTIISNHTPSMQLSCVECGVTKANSEEMEIHIKTEHLKWLPFQCPMCLVERASDAQMREHLHSSHQKNMSKFIYVDNVKAKRRLQILMDSAFSLNVSERVNAKNHPSSSTSASPYSPTSYHRGMNSSPSSGRNTSTSNGSATSAATASAQAAATAIVNHHKEKEKQTAQATADFLKLLDFTGINGEIGEHKAQSSSTRSSSGRKRPYVPTSATEAITTMELAAPSAESFLASLNSFSHAQTPENEENDHPTLFSVDDLNIDSTSTLATLFGGGARKTKYDDGEMPHDEDPLLDSLNPISVLDNVAALFGSTPDRSVETETKKTSSISKKRVLGECSKCQKPVTAGARQMHMFFHLAKDELIFRFRCKHEGCSVEHYRKDQMENHQSKAHGRIDPDMMEDRSLELFQKCQELNHELFVAHRHGHRASPQWTGGSADLAGYQNSQKSKLPGLSSLCSSTAGTAGSTSNGFGPLKLVPDEDHPLQCRLCGKTMQNRIRGFHILWHMAKDKGINRYTCKYCNFGHDRSQSVQVHGKKEHGTDDCVEDRIGEYQDDVKEMSASCFGISSLFAQESKRKNKFPAAAPREHKDLVSMVSSSHEASPAVPVDEEASNDSAIKEEEKPLILNDEEMEELGEDDEVEHEQEHEDEDGEGDEDDDGEGEETTPITSSKSSKKKWRRAFNIRSKKSKKQKEDAVVARSVSILIGGAQFYKKKVNEFCYCEKCGKQTNSRLPEHAYTHMDGVELYSCSACSFGNQCKETVMKHMRESHPLCAERCVDNRLGHIKEIKKQLGQCFPAFFIDHPLPTRSDIEKLQILASGGDLKIGGIEKYLKEECEDGEPSEAPEDEEMEEDDDGVSSD
Protein: Ras-related protein Rab-44 (Q8CB87)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- EF-hand calcium-binding domain-containing protein 4B
- EF-hand calcium-binding domain-containing protein 4A
Sequence:
MEKGKGVSRKGRKLASSRRRQAREPADGQDAPVAAEAESWPSDADAELQGFFQDCGAKERGFVTREDLAEARFSFLGGEEPQMIFDWVDVESRGHLSLEEFSSGLKNVFGSSPGTHRLRTKRSLPSQRESVTSTLPVPEEADAEEKEAFLALIGQMETGHSLSEQAEIWKLWRELRQEEPQLAGNLEGFLAKMSSRLQEAQADREALAWTLRKRDSDHLYKVRQLYEETEEQIRREKQQLQAQSDSRGMALSAHMQEALEAKEQEVQRLAEGQRELEAQLLHLSSTQQEANRENLQLREAERDLAGQLEEVRGQLQVTRGHLDTARTRGKVSWQIEEEPSVPRANKEAPDPQAVPTEEAPLPELFGNNDNWDQFLSSIEAHSHRTLRLCWSPPPSPSSTSAPQTPRIVRQISISKISALQFSQEPASDPDPGPRGSPEVPPGGAKDGKGVEDPKGQDEQDVSSKQPVDSPDSDARPKGSFLWSLPGALTAESGTVEAAFRDQLAFEAEPPPQGLSSSPQSPAGSRKQTQTPDLGDKSLWSGPDPAKQSLEREVMAEDLKLGLGSQGATALPEGATEPSLSLESVDQVGPERPVQDATHLARQESHAKGFQEAPGQVLSLDSLPTHLPQSLEEQLRPEEGNLGERGQQDPGSEASESHGLEARSMESPQQDDPLPNTSQPPAETEVPAPGQMSPPRGSPILGAGAGLAVGTPETTHTLLTLAESEAQPGPVSMPVQVESKSGAPQPTEPEAESRPEDPRTDLQEAERSSSPGDLTAGKPQADPDYLYHVVFLGDSNVGKTSFLHLLHHDAFATGLTATVGVDFRVKNLLVDNKTFALQLWDTAGQERYHSLTRQLLRKAEGVVLMYDVTSQESFTHVRYWLDCLQDAGVEGVAMVLLGNKMDCEEERQVPTEAGRRLAQELGVSFGECSAALGHNILEPMMNLARSLKMQEDRLKASLAEVTHPQSTKRAGCCH
Protein: ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR) (Q9UBJ2)
Organism: Homo sapiens (Human)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:10329405, ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:29397936}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP-binding cassette sub-family D member 1
- ATP-binding cassette sub-family D member 3
- Peroxisomal biogenesis factor 19
- Long-chain-fatty-acid--CoA ligase ACSBG1
- Long-chain fatty acid transport protein 2
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein 4
Sequence:
MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIKNEDETS
Protein: Uncharacterized protein C83.19c (Q9C0W4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MVIDIVTNQFSNLQNIKIFTWKANFESIRINLQHMHLYHYEHIHLFTSSQSYMYHPNARFSYSPFCCFTDTLAYLRCEPYRGYRKCIYRKVKMPNLILRNPLVRYDVSPARYPTIGIRS
Protein: Glia maturation factor gamma (GMF-gamma) (O60234)
Organism: Homo sapiens (Human)
Interaction partners:
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 4
- Lysosomal-associated transmembrane protein 5
Sequence:
MSDSLVVCEVDPELTEKLRKFRFRKETDNAAIIMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLQEKLSFFR
Protein: C2H2-like zinc finger protein (Q9FII6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- C2H2-like zinc finger protein
- Protein METHYLENE BLUE SENSITIVITY 2
- Stress response protein
- Transcriptional regulator SUPERMAN
- KIN17-like protein
Sequence:
MYSLLKKTKICQVCKKSFSNGKALGGHMRAHTLKFFPGSSSSTGSITPSLRSCNNLGASFRRPNETVLARFVHTSEVVGGPKPDLNKEAEQRTTVKKKIVVDLEEENSIESESDITIEESALCLLQMKDDNMSEYLQNLKSIDSLVSTRKRKDTENYIEIDSDENHEDSDDEYVVEDEDEDNEDDDVKSLTSDVENLIGDSDEDDDDYGDENAYYGGKRKRGKKQSKYTCDTCGKVLRSYQALGGHRTSHKYKRLKISDKNYFGEDGPIVRRQYECQICNRMFASGQALGGHKKIHYMFLAPAK
Protein: Protein Wnt (Q3L250)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
Sequence:
PSLGTSTNSAQGKAHVKQCDLLKLSRKQKRLCRREPGLAETLRDAIRLGIMECQFQFRSERWNCSLEGRTSLLKRGFKETAFLYAVSSAALTHSLARACSAGRMERCTCDDSPDLENRKAWQWGVCGDNLKYSTKFLKKFLGQKRIGKDLRAKVDIHNTNVGIKAVKNGLKTTCKCHGVSGSCAVRTCWKQLSPFHEIGRLLKLRYDDAVKVFSTTNDAVGHSELASPQRQSHPTKHHASPRATDLVYVEDSPSFCRPSKYSLGTAGRTCSREGNCDSMCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCMQEEVVYSCKQ
Protein: At3g57220 (Glycosyl transferase family 4 protein) (UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1-phosphate transferase-like protein) (Q9M2M5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- At4g16710
- UDP-N-acetylglucosamine transferase subunit ALG14
- dolichyl-phosphate beta-glucosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- Dolichol kinase EVAN
- Lipid phosphate phosphatase gamma
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic
- Dolichol-phosphate mannose synthase subunit 2
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Dolichol-phosphate mannose synthase subunit 3
Sequence:
MTARKRTPSVSNSEKLALPEPASSPTVQKTSVSGEDFQLAPPKLGVIFVISSLLCSLYLYLLCFHYNVDNELKRPILINAGLSLVGFFVTLKLIPVAARYVLRRNMFGFDINKRGTPQGEVRVPESLGIVVGIVFLIVAIVFQFFNFTEDSVWLVEYNAALASICFMILLGFVDDVLDVPWRVKLLLPSFATLPLLMAYAGHTTIVIPKPLVSYIGLEVFDLGRIYKLYMALLAVFCTNSINIHAGLNGLEIGQTVVIAAAILIHNVMQIGASVDTEYHQAHAFSIYLTQPLMATSLAMLAYNWYPSAVFVGDTYTVFAGMTMAVVGILGHFSETLLIFFLPQVLNFLLSLPQLAGIVKCPRHRLPKYDPATGLLTGTKDGTLVNVYLRIFGRKTEKSLCIHLLVFQALACAFCFMLRHFLAGWYK
Protein: Solute carrier family 41 member (D6RHE3)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}.
Interaction partners:
Sequence:
MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGE
Protein: Myosin motor domain-containing protein (Q95ZU1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDGGATLGRGQLFPLQNFKKGVRIWHRHPTLVWIGATLEEDITFQTRNVRIRLEDDTEVEYAIKSLDQLPFLRNPAFLVGKDDLTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKSAREMDPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTTSIEARVLASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQAPGERNYHIFYQLCAARNHQVLKDLHLGPCESYSYLTQGGDSRIPGVDDKADFEALLKALQLLGFDEKQMSDVFRLLAGLLLLGNVHFENGEGSSAVSASSCQEISRLCREFWKISESDLRIWLTRREIRAVNEIVTKPLTKNEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVLDIYGFETFDVNSFEQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDFHDNQPAIDLIEGPVGMINLLDEQCKRLNGSDADWLSQLQNSTELKRNPQLAFPKVRSNDFIVRHFAADVTYSTDGFVEKNRDAIGEQLLDVVVASKFPFIRTVIGSTAPTSVSSSSSSSTPGKRTIKKTVASQFRDSLKELMSVLCSTRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAGFPSRYPYEEFARRYRVIYTKEAALWRDKPKQFAELACQQCLEEGKYAVGKTKIFLRTGQVAVLERVRLDTLAAAATVIQKMWKGFLARRKYETMRRSLLIVQASLKAFLAFRRIKYLQMHRAVIVMQSAVRGYLERRKYEQIRDSIIGIQAMFKANRVRRYVEKLRYEKSAITIQAAWRGYLARREQIANRKKVVMVQCAVRKWLAKRRLRELKIEARSVGHLQKLNTGLENKIIELQMRLDIANARTKEEAEKFATASKNLQKTKADLAMMEAERLTLLEARNRVEVLQEEVERLETECDLKEAQRGGMETKMVELQSRLDQMQSESGQTIVELTEQLEKAKADRVLWDEERQRMEAALNTERSARNALDAEMAAMREQLMKNVDLFESSTFQKRPSQKKNRDDDSCSRTTSNLSQLTGSFTAETINGVHSTSRGSPEVLLDNMASTFEQLRMINDLRQRNEHCQRETERMKAIIEASTLIETLDKKTSLKAFESIRVGELEGAYNRLKNDMERLVSGENGATHSVFERIMEENERLREEAVELRSMLSSHFEKQSVAGSSGYRRSPRPDSGHCSGADSEDGSSGADLEEDLCIERQCRHLKNLAENLTKMLTNQNLEIERLQQQLRFSESQTVFRPSDCSLDEAVRGAHKQTQLLAQQNMDLNDKLTRQSEELAEARAQLRGYSGPLGLENASDEEIIRLEAFEKGSIKHSGFLEVYNVPEFARIIVCELKPTLARLLTKNLPAYLLVAAFRNHDEKRDETALTGLFSSVHLVLKDTISRSHDLDLLSLWLVNLWRLFNLLRQYSGEDSQPEWHVANTETQNSYRFKAYDVAPIRDQLKLRIEECYTSLMKKAIEHVLSPKIVPGILQHESSSDLMTAGQERRDRNSGSVESQRKSLDDLLQFMEIVHTKLTTYGGDDIVVKQVIGQMARWMCALALNYMMFRRELCNFEKAIQIKHNVTQIQNWLNAKGLSDCRDHFEPLVQACHLLQSRKDPSNLDTLCGEMTSRLKPRQVVAILQHYDPSDEMEDGLSPEFLVQIQKKLNERAIANNDPIEDKDKLIMLGTYLPPFDTQPFSYSDFPLETLSLPSCLHMQSVCRLV
Protein: MYB-like transcription factor EOBI (Protein EMISSION OF BENZENOIDS I) (PhEOBI) (L7R9Z0)
Organism: Petunia hybrida (Petunia)
Function: MYB-type transcription factor controlling the production of volatile organic compounds (VOCs), including floral volatile benzenoids and phenylpropanoids (FVBP), in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26) by regulating the expression of ODO1, a key regulator of the shikimate pathway, and of several biosynthetic floral scent-related genes (e.g. IGS, EGS, BSMT1, BSMT2, PAL1, PAL2, EPSPS, DAHPS, CS, CM1, ADT1 and PPA-AT). Binds to and activates the promoters of at least ODO1, IGS1 and PAL1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:23275577}.
Interaction partners:
Sequence:
MDKRTCNSQDVEVRKGPWTMEEDLILINYIANHGEGVWNSLARSAGLKRTGKSCRLRWLNYLRPDVRRGNITPEEQLLIMELHAKWGNRWSKIAKHLPGRTDNEIKNYWRTRIQKHIKQADQNMKKPSKCEQNDQKAISTSQASTGPTDTIDSYSPSSYTENTNNNMENITFQGNFPTETNENIWSMEDLWSLQLLNDATN
Protein: Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase) (P36365)
Organism: Rattus norvegicus (Rat)
Function: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8504165}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSCDLGGLWRFTEHVEEGRASLYNSVVSNSSKEMSCYSDFPFPEDYPNFVPNSLFLEYLQLYATQFNLLRCIYFNTKVCSITKRPDFAVSGQWEVVTVCQGKQSSDTFDAVMVCTGFLTNPHLPLDSFPGIQTFKGQYFHSRQYKHPDVFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPVVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVLIKPSIKEVKENSVVFNNTPKEEPIDVIVFATGYSFAFPFLDESIVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMIPTGETQARWVVQVLKGATTLPPPSVMMKEVNERKKNKHSGFGLCYCKALQSDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWEGARKAILTQWDRTVNVTKTRTVQETPSTFETLLKLFSFLALLVAVFFIFL
Protein: RNA helicase (EC 3.6.4.13) (A0A024RCM3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR
Protein: Protein TRACHEARY ELEMENT DIFFERENTIATION-RELATED 6 (Q8LBX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the secondary cell wall (SCW) formation of vessel elements (e.g. protoxylem and metaxylem), thus promoting tracheary element (TE) differentiation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:C1PGW0}; Single-pass membrane protein {ECO:0000255}. Secreted, cell wall {ECO:0000250|UniProtKB:C1PGW0}.
Interaction partners:
- Protein CELLULOSE SYNTHASE INTERACTIVE 1
- Cellulose synthase A catalytic subunit 6
- Protein CELLULOSE SYNTHASE INTERACTIVE 3
- Cellulose synthase A catalytic subunit 7
- Cysteine protease XCP2
- Cysteine protease XCP1
- Chitinase-like protein 2
- At5g19870)
- Transmembrane E3 ubiquitin-protein ligase FLY2
- Protein trichome birefringence-like 3
Sequence:
MASTDSVYRPTPTPDHDTTVVVVVFVSLGCVMFLAFLAFVIWFLIKKRSRKHRERSEAVRVDEHFKMKEAIVEGPNGQKSVVLSVEDDVKIEDAIKREEKDLKKDGGVGSSVVSRS