wanglab/gogpt-training-data huggingface dataset:
Protein: T-cell surface glycoprotein CD8 alpha chain (T-cell surface glycoprotein Lyt-2) (CD antigen CD8a) (P01731)
Organism: Mus musculus (Mouse)
Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P01732}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01732}. Note=Cd8a localizes to lipid rafts only when associated with its partner Cd8b. {ECO:0000250|UniProtKB:P01732}.
Interaction partners:
- T-cell surface glycoprotein CD8 beta chain
- T-cell surface glycoprotein CD4
- H-2 class I histocompatibility antigen, K-B alpha chain
- H-2 class I histocompatibility antigen, TLA
- Proto-oncogene tyrosine-protein kinase LCK
- Beta-2-microglobulin
- T-cell surface glycoprotein CD3 epsilon chain
- Tyrosine-protein kinase ZAP-70
- T-cell surface glycoprotein CD3 zeta chain
- T-cell surface glycoprotein CD3 delta chain
Sequence:
MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAELGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVVYMASSHNKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACDIYIWAPLAGICVALLLSLIITLICYHRSRKRVCKCPRPLVRQEGKPRPSEKIV
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (K7EKZ1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRYVRRCVPLPGAPARVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFNNLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERMLHVVDGKVPDTLRKCFSEGEKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVWKDNRTDDIPELHMDLSDIVEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVCHIVLGLRPATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVIEPSSVLNGGKYSFGTAAHPMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFLYSATPGADVCFARQHNTSDNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIPELELFPRYLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYV
Protein: RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (G3X7B5)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
MMGGCRRPAGRGADPSERHESEVWAVLARGSHSSMNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDLEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPGENSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFPEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLSPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFASIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEGVDSERRPHFPQFSYSASGTA
Protein: Copine-4 (Copine IV) (Q8BLR2)
Organism: Mus musculus (Mouse)
Function: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Interaction partners:
Sequence:
MKKMSNIYESAANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGMVILNQCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKPKCSSEVYESSRTLAP
Protein: NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) (NADH dehydrogenase subunit 2) (P11662)
Organism: Rattus norvegicus (Rat)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03892}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase 1 subunit C1, mitochondrial
- Acyl carrier protein
- NADH dehydrogenase Fe-S protein 7, isoform CRA_d
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Cytochrome b
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
Sequence:
MNPITLIIIYFTILMGPVITMSSSNLLLMWVGLEMSLLAIIPLLANKKSPRSTEAATKYFLTQATASMIILLVIILNYKQSGMWTLQQQTNNMLLNMMLISLAMKLGLAPFHYWLPEVTQGIPLHIGLILLTWQKIAPLSILYQFYQLLNPTITTILAISSVFVGAWGGLNQTQTRKIMAYSSIAHMGWMTAILPYNPNLTLLNLTIYILLTVPMFITLMTNSATTINTLSLAWNKTPMILTMTSIILLSLGGLPPLTGFLPKWAIISELLKNNCSTLSTLMAIMALLSLFFYTRLIYSMSLTMFPTNNNSKMISHHHQNPKHNFILPTLTVLSTLTLPLSSQLIT
Protein: Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41) (Q3TUH1)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side {ECO:0000250|UniProtKB:P53230}.
Interaction partners:
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
- Tafazzin family protein
- PRELI domain-containing protein 1, mitochondrial
- Phosphatidate cytidylyltransferase 2
- Phosphatidate cytidylyltransferase 1
- Cardiolipin synthase
Sequence:
MALQALHSSGVGLRRILAHFPEDLSLAFAYGSAVYRQAGPSAHQENPMLDLVFTVDDPVAWHAMNLKKNWSHYSFLKLLGPRIISSIQNNYGAGVYFNPLIRCDGKLIKYGVISTGTLIEDLLNWNNLYIAGRLQKPVKIVSMNENMALRAALDKNLRSAVTTACLMLPESFSEEDLFIEIAGLSYSGDFRMVIGEEKSKVLNIVKPNVGHFRELYESILQKDPQVVYKMHQGQLEIDKSPEGQFTQLMTLPRTLQQQINHIMDPPGRNRDVEETLLQVAQDPDCGDVVRLAISSIVRPSSIRQSTKGLFTAGMKKSVIYSSRKLNKMWKGWMSKAS
Protein: Protein phosphatase 1 regulatory inhibitor subunit PPP1R8 homolog (Q9FIK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibitor of protein-phosphatase 1 (PP1). Binds to and inhibits PP1 activity.
Interaction partners:
- Nucleobase-ascorbate transporter 11
- DNA-binding protein S1FA1
Sequence:
MYGRSGLDRFKKSQTSEPFSVSANPPPVVQQHLSPEALSGQKTQIGAGQSNWHPPDWAIEPRAGVYSLEVVKDGQILDRIHLDRRRHIFGRQHQTCDFVLDHQSVSRQHAAVVPHKNGSIFVIDLGSAHGTFVANERLTKDTPVELEVGQSLRFAASTRIYLLRKNSEALFSRPPPPAEIKLPPPPDASDEEAVVAYNTLLNRYGLSNGESGGMLGKRKEKTGSEAGVAKRMKKVRVSFRDQLGGELAEIVGMSDGADVETEPGPINVKEGSLVGKYESLVRVTLIPKGKVKEEKAFTGGTRGGVTDRLQEAMNMLKRGPKTGIYDDLYGGDSLAKAVGTSWASVSQPAAETECGGVGEEDDNDDLFGD
Protein: Monothiol glutaredoxin-S6 (AtGrxS6) (Protein ROXY 17) (Q9LYC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MESVRSLVEDKPVVIFSKSSCCMSHSIQTLISGFGAKMTVYELDQFSNGQEIEKALVQMGCKPSVPAVFIGQQFIGGANQVMTLQVKNQLAAMLRRAGAIWV
Protein: Probable zinc transporter 10 (ZRT/IRT-like protein 10) (Q8W245)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably mediates zinc uptake from the rhizosphere.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative zinc transporter At3g08650
- Protein yippee-like At4g27740
- TPR repeat-containing protein ZIP4
- Heavy metal-associated isoprenylated plant protein 2
- Putative cadmium/zinc-transporting ATPase HMA4
- IAA-alanine resistance protein 1
- Chaperone DnaJ-domain superfamily protein
- Zinc transporter ZTP29
- Heavy metal-associated isoprenylated plant protein 25
- Metal tolerance protein 1
Sequence:
MTKSHVIFSASIALFLLLSISHFPGALSQSNKDCQSKSNYSCIDKNKALDLKLLSIFSILITSLIGVCLPFFARSIPAFQPEKSHFLIVKSFASGIILSTGFMHVLPDSFEMLSSPCLNDNPWHKFPFAGFVAMMSAVFTLMVDSITTSVFTKSGRKDLRADVASVETPDQEIGHVQVHGHVHSHTLPHNLHGENDKELGSYLQLLRYRILAIVLELGIVVQSIVIGLSVGDTNNTCTIKGLVAALCFHQMFEGMGLGGCILQAEYGWVKKAVMAFFFAVTTPFGVVLGMALSKTYKENSPESLITVGLLNASSAGLLIYMALVDLLAADFMGQKMQRSIKLQLKSYAAVLLGAGGMSVMAKWA
Protein: Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (Leukotriene B4 receptor BLT2) (Q9JJL9)
Organism: Mus musculus (Mouse)
Function: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Leukotriene B4 receptor 1
- Guanine nucleotide-binding protein G
- Leukotriene A-4 hydrolase
- Guanine nucleotide-binding protein subunit alpha-14
- Cysteinyl leukotriene receptor 1
Sequence:
MSVCYRPPGNETLLSWKGSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPTAGRPLAATLVLHLALADGAVLLLTPLFVAFLSQEAWPLGQVGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLGVWLAALVLAVPAAVYRHLWGGRVCQLCHPSPVHAAAHLSLETLTAFVLPFGTVLGCYGVTLARLRGARWGSGRQGTRVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGPLARLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGSRSREGTMELRTTPKLKVMGQGRGNGDPGGGDGGKTEKDSQEW
Protein: Amino acid transporter heavy chain SLC3A1 (D2h) (Neutral and basic amino acid transport protein) (NBAT) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transporter-related heavy chain) (rBAT) (Q07837)
Organism: Homo sapiens (Human)
Function: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12167606, ECO:0000269|PubMed:32817565}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q91WV7}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- b
- Prolyl endopeptidase-like
- Protein phosphatase 1B
- Angiotensinogen
- Calmodulin-lysine N-methyltransferase
- Large neutral amino acids transporter small subunit 1
- Y+L amino acid transporter 2
- Y+L amino acid transporter 1
- Solute carrier family 7 member 13
- Large neutral amino acids transporter small subunit 2
Sequence:
MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFKGVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC
Protein: Bidirectional sugar transporter SWEET10 (AtSWEET10) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 10) (Q9LUE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
Interaction partners:
- Leucine-rich repeat
- Monosaccharide-sensing protein 2
Sequence:
MAISQAVLATVFGILGNIISFFVCLAPIPTFVRIYKRKSSEGYQSIPYVISLFSAMLWMYYAMIKKDAMMLITINSFAFVVQIVYISLFFFYAPKKEKTLTVKFVLFVDVLGFGAIFVLTYFIIHANKRVQVLGYICMVFALSVFVAPLGIIRKVIKTKSAEFMPFGLSFFLTLSAVMWFFYGLLLKDMNIALPNVLGFIFGVLQMILFLIYKKPGTKVLEPPGIKLQDISEHVVDVVRLSTMVCNSQMRTLVPQDSADMEATIDIDEKIKGDIEKNKDEKEVFLISKN
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) (Q9CQZ6)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000250|UniProtKB:O43676}; Matrix side {ECO:0000250|UniProtKB:O43676}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 alpha subcomplex subunit 3
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
MAAGHGHEHGHEHGHGHGKMELPDYRQWKIEGTPLETVQKKLAARGLRDPWARNEAWRYMGGFAGNITFPSVILKGFKWGFAAFVVALGAEYFLDSQNGDKKHH
Protein: Pur-alpha (O16860)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDLGSGDDGISGSKYNVANMEGSSSRNDFDSSAKGRSGVEQELATKMLQIQSKRFYLDVKQNRRSRFIKVAEIGADGRRNPILGSFTAAEFRDHLSSFSDYYASLSPQNTDNLPEDGKLKSEMMIKDYRRYYLDLKENARGRFLRVSQTITRGGPRSQIALPAQGMIEFRDALTDLLEEFGANDGGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSITIPEKCWIRFRDIFNDYCEKMKKSSDSITAEINLPTSSNSLK
Protein: DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) (Q02535)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor E2-alpha
- Transcription factor 4
- DNA-binding protein inhibitor ID-1
- Paired box protein Pax-5
- Transcription factor 12
Sequence:
MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISNDKRSFCH
Protein: Ubiquitin-like-specific protease 1 (EC 3.4.22.68) (Q02724)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle.
Interaction partners:
- Ubiquitin-like protein SMT3
- Importin subunit beta-3
- Importin subunit alpha
- Ubiquitin-like-specific protease 2
- Nucleoporin NUP60
- E3 SUMO-protein ligase SIZ2
- Importin subunit beta-1
- SUMO-conjugating enzyme UBC9
- Ubiquitin-activating enzyme E1-like
- E3 SUMO-protein ligase SIZ1
Sequence:
MSVEVDKHRNTLQYHKKNPYSPLFSPISTYRCYPRVLNNPSESRRSASFSGIYKKRTNTSRFNYLNDRRVLSMEESMKDGSDRASKAGFIGGIRETLWNSGKYLWHTFVKNEPRNFDGSEVEASGNSDVESRSSGSRSSDVPYGLRENYSSDTRKHKFDTSTWALPNKRRRIESEGVGTPSTSPISSLASQKSNCDSDNSITFSRDPFGWNKWKTSAIGSNSENNTSDQKNSYDRRQYGTAFIRKKKVAKQNINNTKLVSRAQSEEVTYLRQIFNGEYKVPKILKEERERQLKLMDMDKEKDTGLKKSIIDLTEKIKTILIENNKNRLQTRNENDDDLVFVKEKKISSLERKHKDYLNQKLKFDRSILEFEKDFKRYNEILNERKKIQEDLKKKKEQLAKKKLVPELNEKDDDQVQKALASRENTQLMNRDNIEITVRDFKTLAPRRWLNDTIIEFFMKYIEKSTPNTVAFNSFFYTNLSERGYQGVRRWMKRKKTQIDKLDKIFTPINLNQSHWALGIIDLKKKTIGYVDSLSNGPNAMSFAILTDLQKYVMEESKHTIGEDFDLIHLDCPQQPNGYDCGIYVCMNTLYGSADAPLDFDYKDAIRMRRFIAHLILTDALK
Protein: Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) (P20809)
Organism: Homo sapiens (Human)
Function: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.
Subcellular location: Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
Interaction partners:
- Interleukin-11 receptor subunit alpha
- Interleukin-6 receptor subunit beta
- Interleukin-6 receptor subunit alpha
- Interleukin-6
- Oncostatin-M-specific receptor subunit beta
- Leukemia inhibitory factor receptor
- Ciliary neurotrophic factor receptor subunit alpha
- Oncostatin-M
- Leukemia inhibitory factor
- Ciliary neurotrophic factor
Sequence:
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
Protein: Regulator of G-protein signaling 1 (RGS1) (Q9JL25)
Organism: Mus musculus (Mouse)
Function: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q08116}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q08116}; Cytoplasmic side {ECO:0000250|UniProtKB:Q08116}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q08116}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
Sequence:
MRAAAISMPRLNKMPGMFFSASPKDSKEHSHSLLDDKKQKKRPKTFGMDVKTYLRSMIPHLESGMKSAKSKDILSAEEVMQWSQSLEKLLANQTGQNVFGRFLKSEFSEENIEFWLACEDYKKTETDLLHNKAENIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTSFDEAQKVIYSLMEKDSYPRFLKSNIYLNLLNDLQANTLK
Protein: Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi-enriched fraction casein kinase) (GEF-CK) (Q5MJS3)
Organism: Mus musculus (Mouse)
Function: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (By similarity). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (By similarity). This is critical to maintain ER proteostasis and reduce cell death under ER stress (By similarity). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (By similarity). Required for osteoblast differentiation and mineralization (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IXL6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IXL6}. Secreted {ECO:0000269|PubMed:17369251}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IXL6}. Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage. Retained in the endoplasmic reticulum (ER) in response to ER stress where it phosphorylates P4HB. {ECO:0000250|UniProtKB:Q8IXL6}.
Interaction partners:
- Pseudokinase FAM20A
- Fibroblast growth factor 23
- Dentin matrix acidic phosphoprotein 1
- Amelotin
- Enamelin
- Ameloblastin
Sequence:
MKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSSGEPGCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSLEKLPSAAEPVDHAPRGQEPRSPPPRDPAHRPLLRDPGPRPRVPPPGPSGDGSLLAKLFEHPLYQGAVPPLTEDDVLFNVNSDIRFNPKAAENPDWPHEGAEGAEFLPTGEAAVNLYPNWLKFHIGINRYELYSRHNPAIDALLRDLGSQKITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGLSSVVEDDLATEHRASTER