wanglab/gogpt-training-data huggingface dataset:
Protein: Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Q8CG09)
Organism: Rattus norvegicus (Rat)
Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15129170}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P33527}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Broad substrate specificity ATP-binding cassette transporter ABCG2
Sequence:
MALSSFCSSDGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFLYLSRHDRGYIQMTHLNKAKTALGFFLWIICWADLFYSFWERSQGMLLAPVLLVSPTLLGITMLLATFLIQFERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFTLVFIQLVLSCFSDSSPLFSETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAKDAGLV
Protein: Possible dual specificity protein phosphatase 3 (AFU_orthologue AFUA_1G13040) (C8VU74)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MEPTASGLETSLSGNAKSQYIRNHQYTKKIAASYYPDIHYHGLNQPAPEPIGPGSHQFREGEFVSPGFFQHIDPSIFTLPRSEVEWTYNMRRTAQRMLPFLYLGPWNALSNKQWLRDEGITLLLGVRDQRLAQSRLFSGQKAAAEVGIEADSFDIVDGQDLIARLPETIRRINDHIYPSAGFAAGAPTPKKVLVFCETGNGLSALVVVAYCMVMLNMSLIQAMNFIHSQRFCIDMEDGLRPMLLAFEGLLKAKRDVEKANKAAGANFLLTTPAMTLSKKRSFADHEEDDTMEDDSMDLERKPTAPFQDRWA
Protein: Present in the outer mitochondrial membrane proteome 22 (Q586D8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMRKNLNSNDVSQPHSTTTLDTNPASYGTVRNPLHSVVGPTGYGAQPPISSPATWVNNHSAAFAAQGLGPHCGAPGGRPFPVVRGSTNRGDSYTELQCPVAGSGPTNPYGNRTAIDKLPGLEGGRFDCGGAGQRRGPLLGVSGDLYGVTGISNSTSRGNDRHNGSMYGTNPTYSKTSRTGSMYGMGSMYGRTSRIGSMYGMGSMYGRTSRTGSMYGMGSMYGRTSRIGSMYGRTSRIGSMYGRTSGTGSMYGMGSIYGMGSMYGRTSRTGSMYGPRMEYGPIYGVGGPMGSMYGPQMGYGPIYGVGGPTGSMYGPQMGYGPIYCVGPMYGRPSRTDSVYGPQMGHGPMYCVGGLLYNKAFQEGDPGRGPTVPKSAPCNSSTPSAGVTTKPDAEPDREEKEPRVTGGKKPTTFTNKGPAAETAKKPCDLDSGNGKVKHSPVAQVPPDNSVRTLMVVSSEAGPQVTIKEEERKVGVASSGEEVVYYEGDEVVHGDEITVEKSALLQMIVQQVELGHNTALILSDSTPQQTLSACVTTSVMKSILAALRKGETENGTKYEVLATAADVPTIATARDLLAVESEAVKIARYGSNPMLGACLMDLQETVLRDDADVDVFVQEALKKSSGTAALGVMHATLKQIRKTSSAAPTVYVSSFVCLFVKDGVEHLQDLLDMNGKVVPLPLAKSVLGGGSCVVAVVGASGKDVAVDAKILSNTAALRGVKNTPPRSGNVARFVEFAETQFTECKAAIERSKEAAERERHERTLRRLEIMLSDARKLLSDPEETRAKVYPPSRESVKNGSVENDGGNVRNGASIEDDRPSAATLAPAPASADSLTEPKEQEVIGAPAPAHTTEPWEKTAKIIVTAGSGPSNGTAEVVAGGEKKTDEVDEYIQRTGVRPVDSVIAKRMEGILTQGYNVALLSAEMVPDEVTGDQVTWSLVKAILKGALSKKDGVTNECTLQMSILRGDKVVLDLLGSSEKRQLVVARSPIFGVTVQGATTKVVGSAVQVEPVLEAALMEAKDAFKDSGYIVFTAVLKQVTAADVSVSSLFVVSAPDMQPFVDALEKKETHPHALFAHALLGPCSCALLVSYRDVDDNVLKALDAHREITLKNNKQPGGSVRKFVGVVEQSITAAEEKLKSVDDAKERERHEQVLRDKKQALHDAQKLLEKPNETQPVAYVPSISQESGGADSTVRVVAVLTDKRDGKKRNVIAKDNGFTIKTSVEETEFPADEVVRRIGQAAKIRSSSVDFLIDHFVKGYNVALLTADVDGFSTGENLLEHTVRSVFTKKNADGELFVVLASIKADCCSAKDLQRDGATYDQLQCASSPLFGPCVADAKFELATTPDTLLRKVRSAIQVCEADKSTLLCLFVYKERKPADGDVFLSSFFFFLAGSRVDIYTQALEKRQKERGLFQYALGGPCLTAFALGLSTSNSDVETATAFVRLAKKVRGSKIGTIRTGGIQRFVAFSTKALEQLRVLQEKAPESDRGRLRESSTNVEKVLADAEELLRNPEGRAPPLYKQER
Protein: Cytochrome c1, heme protein, mitochondrial (EC 1.10.2.2) (D6XKS6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Mitochondrial processing peptidase alpha subunit, putative
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase, mitochondrial, putative
- Reiske iron-sulfur protein, mitochondrial
- Electron transfer protein, putative
- NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial
- Cytochrome c
- Acyl carrier protein
- Mitochondrial processing peptide beta subunit, putative
- Mitochondrial processing peptidase, beta subunit, putative
Sequence:
MAGKKAHPIKRDWYWNHNDRFEIWHSLDWPSVRRGRQIYTEVFAPCHPLGRMTFTHFQGFMTREEIKQLASQYEVVDSAPDAQGMLNPRPGKPTDTLPIPFPNQRAAQFANNGSEPPDLQHSVFGKEGGPDYIFSLITGYNWGNGELMEIPPFAPELKPGQFWNPYFKDCVLSMPPPLSDGMVDYEDGTPATISQMAKDVVNFLRWSAESEYDDRRVMFWKCFTTLGLVNCILLHYCQKNTNWRIYGRTTFRYWKKTW
Protein: ORF7b protein (ORF7b) (Accessory protein 7b) (P0DTD8)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Subcellular location: Host Golgi apparatus membrane {ECO:0000269|PubMed:33060197}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q7TFA1}. Host endosome membrane {ECO:0000269|PubMed:33060197}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q7TFA1}.
Interaction partners:
Sequence:
MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA
Protein: Probable ribosome-binding factor A, chloroplastic (O65693)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL18z
- Small ribosomal subunit protein uS4z
- Small ribosomal subunit protein uS4y
- U3 small nucleolar ribonucleoprotein protein IMP3
- Small ribosomal subunit protein uS4c
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein bS16cy
- Small ribosomal subunit protein uS7cz/uS7cy
Sequence:
MPNLLHTNQSHFFFLHHPPIYTVSSKTQAFHFPQSMAPVNLRTNLSVRRTVRCMANPRRVKMVAKQIMRELSDMLLTDTVLQHAVLPEAALGADRYLSSLTTISDVEVSNDLQVVKVYVSVFGDDRGKDVAIAGLKSKAKYVRSELGKRMKLRLTPEVRFIEDEAMERGSRVIAILDKIKAEKGSGEGKTEPSDSTEDDQDWEVDDPDEDIIYVK
Protein: Defensin-like protein 204 (Q56XB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Uncharacterized protein
- Uncharacterized protein
- Transmembrane protein
- Uncharacterized protein
- STAY-GREEN-like protein
- Glycine-rich protein homolog
- Uncharacterized protein
- UPF0496 protein At3g49070
Sequence:
MAKTFSSICFTTLLLVVLFISTEIPKSEAHCDHFLGEAPVYPCKEKACKSVCKEHYHHACKGECEYHGREVHCHCYGDYH
Protein: Signal recognition particle receptor FtsY (SRP receptor) (EC 3.6.5.4) (P83749)
Organism: Thermus aquaticus
Function: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00920}.
Interaction partners:
Sequence:
MGFFDRLKAGLAKTRERLLKAIPWGGNLEEVLEELEMALLAADVGLSATEEILQEVRASGRKDLKEAVKEKLVGMLEPDERRATLRKLGFNPQKPKPVEPKGRVVLVVGVNGVGKTTTIAKLGRYYQNLGKKVMFCAGDTFRAAGGTQLSEWGKRLSIPVIQGPEGTDPAALAYDAVQAMKARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIAKADPEEPKEVWLVLDAVTGQNGLEQAKKFHEAVGLTGVIVTKLDGTAKGGVLIPIVRTLKVPIKFVGVGEGPDDLQPFDPEAFVEALLED
Protein: Cell surface superoxide dismutase [Cu-Zn] 6 (EC 1.15.1.1) (Predicted GPI-anchored protein 9) (Q5ACV9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. May be involved protection against extracellular stress.
Subcellular location: Secreted, cell wall. Membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP). {ECO:0000250}.
Interaction partners:
- Superoxide dismutase 1 copper chaperone
- Peroxisomal catalase
Sequence:
MIFIPIIILIYLVSIAASDKSPKIKKNPRNVVAVADFPFGGDTQVKGNVVFSAKEGKHVNVHIDMTGLPKDEGPFFYHIHERSVPGNGNCEAVGLHFNPYNASPVCDEQKNDAYCQVGDLSGKHGCINTTCFELKYSDPYLSLNRKSKSYIIGKSVVFHYPNLTKIACADIEEANELRLQSLIDEYTQTDDAIQLKELNTPLETDYKFDEVEALSSEIYHSDTDSDPPQQELISTEKLYNKTDNVYSPEETRPSDQNKKSHRHSLLPLAKWKKNSPKNYSNISIHGISSDCLNDGMMVTGSVFGSLVLGIAAGIFV
Protein: Amino acid starvation-responsive transcription factor (A0A1D8PIL5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Pcl5p
- Negative regulator of the PHO system
- Eukaryotic translation initiation factor 2 subunit alpha
- Small ribosomal subunit protein mS37
- non-specific serine/threonine protein kinase
- Mtf2-like C-terminal domain-containing protein
- Transcriptional regulator SKO1
- Serine/threonine-protein kinase ATG1
- Rca1p
- Transcription factor
Sequence:
MPATTPIIYEDSLFESQDLFASPFKQQHQKVDTVATKNEIGLELNLGLPEMQKASETVSTPFQIHSSVLESVFSTNLDGVNDIDHTPMFDELDLIMDGAKVNSSEDWVALFGDDNDDGVAIAGATSKEPMLSLNEDNENNDDDADDDDDDDDALVPREDTIEALLLEPSPNRTISAATSASTSSLNSPESTIATTVTAGGEVVVASKKQFQLVTPNPSSTLPTPLLDSKNSKKRVKVDHLGCVTYSKKHRSQPLQPIVVDDIKDAAALKRAKNTEAARRSRARKMERMSQLEDKVENLINEKQALQDQVERLQELLRVNGIQF
Protein: Cytochrome c proximal, isoform B (GEO08274p1) (X2J6D4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
Sequence:
MGVPAGDVEKGKKLFVQRCAQCHTVEAGGKHKVGPNLHGLIGRKTGQAAGFAYTDANKAKGITWNEDTLFEYLENPKKYIPGTKMIFAGLKKPNERGDLIAYLKSATK
Protein: Uncharacterized protein (Q86KX8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- SAP DNA-binding domain-containing protein
- DNAJ heat shock N-terminal domain-containing protein
- BAR domain-containing protein
- Regulator of chromosome condensation domain-containing protein
- Calponin-homology
- Phospholipase D B
- Ankyrin repeat-containing protein
- LIM domain-containing protein D
- LIM domain-containing protein C
- Calcium-regulated actin-bundling protein
Sequence:
MNKDQHEKIKHLEDENEDLKKRIKQKAQQFDNQADVLKVTQKTATELKNEKNKILSELKLVEEKFNNGQIEIKKLQEILKQTKTNHQKVCELIDQLKVEKGNLEKQHQKEMREFEDKTNKQIEIQTEKLEKLINETDKLRCDKSNLEVRIVHLENSNKENKSYLLQSNKEMGKMEIEIQQLQEQLTDSKEQESNQRSKIENKDIMIQQLRDKQQQYEKELRELQHQFNADNEKNQQIIDIQSEEISTSTLIMTELEEKLEFVSDKLKSEQEKLKESEILIMDLQIQVSDLQSTSDDDNERYQSLISEYQENLKSVSQLNKEINEKLKNERTESKSLIDKISKENNDYQILITEQDKDLKDLKSQLDTKSNNYSKLLDDLSLSKLNYNKLNLEFNNISNEYQIEKQQLSFDFNELKKKLDDQIERNSNQQSLLTQRINEIIDKQKEIDNLNSDLQSLNDKQSDSNDQINTITNENNDLKIKLENSILLISNHQDKLTTNKKELESLYSIIENLNSTHQDQLKEKENQIEQMKLDQSESLNKFQEKITTLNHTIVNINSEKDSLNCLINDYSEQINELNKINNQKNQENQQLLSSIREDCQTINQLKSTIKSLQDESNSLSTEIEAIKLQLNQLSTITIPEKDQELSNKERTIQEFQVKTQQLKQTIQQNQLTINQHLTTIDNQSVDINSLNEKLVQLNDESIKKQQSIHSLSLQVIELNKKLSEKDDQYNQSLESIDQLTSELQLKQDDLNRQQEQLQKNSIDIDQLFDKINLGKSNFDELNQRYQVEQNQLFNLKQDLQQSINLFNESKLYTTQLEKSIEQVKRVNEEQSNHQGELTILLDEERYKCQTLKMDLENSKQINQNQSDDLNFYNNQIEQLKQQLSESKELVQECKLSISQFEKTVIELQLEIKELSNEKQQYQETCQSLSLKLSKLNDQSNDQLEQIQQLQSSNSLDLQNSQNQISLLQDSLNETSDLKSQLQCQLNESNEIISKLELKIEENQNQLTEFELKIQSLSSQYNQDLQEQIEQSKMLIDEKQSCIQLQEMEIDKNNHKIQQLQQDLSTSDYKIQQLQIDLQIDKDEIIKLEETISQRNQSIKESLVKCNDLQDETSKLNDNLLQLNSTITDYQSQITESNENVQSLQNEKNQLQLELDQLKQRISEQHDDITLLNSIEFELNRKISNYQSDIKEYDNNIKVIQNEKNQLQLELDQLKQVLSDKQDGVSTLNSTLLELNKKINDYQMEINDSQSNYQELIDEKNQLQLEFDRLKQQLFEKQDEISTLKQDIQLFNSNKKNSDSSIDQLSNHVTELKSKNQQLLLDLSNELERNKLQNDMITQLKENVELEKQNSFENQSKSDDIKSKLDEMIQEFKEVTQNLQEKTNENSNLQCKLDQLEQEIKFEKESNTHLRKENDKDTLVIKQLEQSISQLEHLHSQQTENYLKERELIQQQHQDEKQSSIQSTHQLKSKFDEKQQQYDESLEKLSQSKQELNKLKQEFDLNILVIQKLQDDKQSQSDSNLQLKSNLEEQQLQNQESIEKISTLQQQVNHLQQQFNINTLEIQKLQDEKQLSIESIHQLKSKFDEKQQQYNESIEKSNDLQKQSDQLQQKLENSTNENQQLQEKISTIQLEQINNVQQDDSKDLIIKQLQQSLLDKDDELTTLFENYEQLIKKNKIDEKKIRTLESKLNSINSTVNHNLPIKKPLEEVSNSKINIISSSSPSKLEQLQTVSNQQSQQQKPTINKPPLQIKRKIDFNSQDNLKKTKPFQSTTTTTTTTTTTTTK
Protein: Thy-1 membrane glycoprotein (Thy-1 antigen) (CD antigen CD90) (P01830)
Organism: Rattus norvegicus (Rat)
Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Integrin alpha-D
- Integrin beta
- 5'-nucleotidase
- CD34 molecule
- Receptor-type tyrosine-protein phosphatase C
- Integrin beta-1
- CD44 antigen
- Rho GTPase-activating protein 35
- Rho GTPase-activating protein 5
- CD166 antigen
Sequence:
MNPVISITLLLSVLQMSRGQRVISLTACLVNQNLRLDCRHENNTNLPIQHEFSLTREKKKHVLSGTLGVPEHTYRSRVNLFSDRFIKVLTLANFTTKDEGDYMCELRVSGQNPTSSNKTINVIRDKLVKCGGISLLVQNTSWLLLLLLSLSFLQATDFISL
Protein: Protein C10 (Q99622)
Organism: Homo sapiens (Human)
Function: In brain, may be required for corpus callosum development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23453666}.
Interaction partners:
- Ankyrin repeat domain-containing protein 50
- HLA class I histocompatibility antigen, B alpha chain
- Placenta-specific gene 8 protein
- HLA class I histocompatibility antigen, A alpha chain
Sequence:
MASASTQPAALSAEQAKVVLAEVIQAFSAPENAVRMDEARDNACNDMGKMLQFVLPVATQIQQEVIKAYGFSCDGEGVLKFARLVKSYEAQDPEIASLSGKLKALFLPPMTLPPHGPAAGGSVAAS
Protein: Fibroleukin (Fibrinogen-like protein 2) (pT49) (Q14314)
Organism: Homo sapiens (Human)
Function: May play a role in physiologic lymphocyte functions at mucosal sites.
Subcellular location: Secreted.
Interaction partners:
- Low affinity immunoglobulin gamma Fc region receptor II-b
- Fibrinogen beta chain
- Fibrinogen gamma chain
- Fibrinogen alpha chain
- Thrombospondin-1
- Fibrinogen-like protein 1
- Fibronectin
- Alpha-2-antiplasmin
- Membrane-spanning 4-domains subfamily A member 6A
Sequence:
MKLANWYWLSSAVLATYGFLVVANNETEEIKDERAKDVCPVRLESRGKCEEAGECPYQVSLPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQADDNGDPGRNGLLLPSTGAPGEVGDNRVRELESEVNKLSSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANLTFVVNSLDGKCSKCPSQEQIQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYRLHVGNYNGTAGDALRFNKHYNHDLKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAHPGGYKSSFKEAKMMIRPKHFKP
Protein: Molybdenum cofactor biosynthesis protein B (P0AEZ9)
Organism: Escherichia coli (strain K12)
Function: May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity.
Interaction partners:
- Cyclic pyranopterin monophosphate synthase
- Molybdopterin synthase catalytic subunit
- GTP 3',8-cyclase
- Molybdopterin synthase sulfur carrier subunit
- Molybdopterin molybdenumtransferase
- Molybdopterin adenylyltransferase
- Molybdopterin-synthase adenylyltransferase
- Molybdopterin-guanine dinucleotide biosynthesis adapter protein
Sequence:
MSQVSTEFIPTRIAILTVSNRRGEEDDTSGHYLRDSAQEAGHHVVDKAIVKENRYAIRAQVSAWIASDDVQVVLITGGTGLTEGDQAPEALLPLFDREVEGFGEVFRMLSFEEIGTSTLQSRAVAGVANKTLIFAMPGSTKACRTAWENIIAPQLDARTRPCNFHPHLKK
Protein: Flagellar transcriptional regulator FlhD (P0A8S9)
Organism: Escherichia coli (strain K12)
Function: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Subcellular location: Cytoplasm.
Interaction partners:
- Flagellar transcriptional regulator FlhC
- Putative anti-FlhC
- Motility protein B
- RNA polymerase sigma factor FliA
- Flagellar protein FliL
- Flagellin
- Flagellar hook-associated protein 2
- Chemotaxis protein CheA
- Flagella basal body P-ring formation protein FlgA
- Flagellar FliJ protein
Sequence:
MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
Protein: Spore-wall fungal hydrophobin dewA (P52750)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Secreted, cell wall. Spore wall.
Interaction partners:
- Class I hydrophobin rodA
Sequence:
MRFIVSLLAFTAAATATALPASAAKNAKLATSAAFAKQAEGTTCNVGSIACCNSPAETNNDSLLSGLLGAGLLNGLSGNTGSACAKASLIDQLGLLALVDHTEEGPVCKNIVACCPEGTTNCVAVDNAGAGTKAE
Protein: Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) (D3ZF92)
Organism: Rattus norvegicus (Rat)
Function: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O75509}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O75509}. Note=Endocytosed following oxidation in response to reactive oxygen species (ROS). {ECO:0000250|UniProtKB:O75509}.
Interaction partners:
- Amyloid-beta precursor protein
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Caspase-6
- Amyloid beta precursor like protein 2
- Tumor necrosis factor receptor superfamily member 1A
Sequence:
MGTSASSITALASCSRIAGQVGATMVAGSLLLLGFLSTITAQPEQKTLSLTGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPSGTFTRHENGIERCHDCSQPCPRPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKGTENEDVRCKQCARGTFSDVPSSVMKCRAHTDCLGQNLMVVKQGTKETDNVCGVHLSSSSTTPSSPGIATFSHPEHTESHDVPSSTYEPQGMNSTDSNSTASVRTKVPSDIQEETVPDNTSSTSGKESTNRTLPNPPQLTHQQGPHHRHILKLLPSSMEATGEKSSTAIKAPKRGHPRQNPHKHFDINEHLPWMIVLFLLLVLVLIVVCSIRKSSRTLKKGPRQDPSAIMEKAGLKKSLTPTQNREKWIYYRNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNVKLENSTLLTVEPSPLDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
Protein: Interferon beta (IFN-beta) (Fibroblast interferon) (P01574)
Organism: Homo sapiens (Human)
Function: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:6157094}.
Interaction partners:
- Interferon alpha/beta receptor 2
- Interferon alpha/beta receptor 1
- Toll-like receptor 4
- Toll-like receptor 3
- Interferon alpha-1/13
- Interferon regulatory factor 3
- Interferon regulatory factor 7
- Serine/threonine-protein kinase TBK1
- Receptor-interacting serine/threonine-protein kinase 1
- TNF receptor-associated factor 3
Sequence:
MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
Protein: DNA polymerase alpha-binding protein (Chromosome replication protein CHL15) (Chromosome transmission fidelity protein 4) (Protein POB1) (Q01454)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Accessory factor for DNA replication. It plays a role in accurately duplicating the genome in vivo.
Subcellular location: Nucleus.
Interaction partners:
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM6
- DNA replication complex GINS protein PSF2
- Chromosome segregation in meiosis protein 3
- DNA replication licensing factor MCM4
- Cell division control protein 45
- Minichromosome maintenance protein 10
- DNA replication complex GINS protein PSF1
- DNA replication complex GINS protein PSF3
- DNA polymerase alpha catalytic subunit A
Sequence:
MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK