wanglab/gogpt-training-data huggingface dataset:
Protein: Protein bir1 (A0A1D8PSZ1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Aurora kinase
- ATP synthase subunit beta
- Inner centromere protein ARK-binding domain-containing protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin
- E2 ubiquitin-conjugating enzyme
- Histone demethylase
- Protein ECM5
- RING-type domain-containing protein
- E2 ubiquitin-conjugating enzyme
Sequence:
MANINHEMIYRDHRLKTFEDPIKIGNKSLAWDEFSDVENFDRLIDSGFYYNPTPRSKTRITCAYCGNSEIIKSNKDVENINTKHLRRNSSCPMSLIANIDDIITSFNQNRDELKNFWTDHEKFNDPFQSKTIEFRKQFYVNYPLDKIDSIPNSNSLSHAGFIYSPRSIEDDRVRCMYCQCALDYWEEDDDPIQEHIRNESTYCYFLDLYNNEQDGDKDSLELENPITKSINDIDHEEGNIDNKIDNNNDYNNNDNDDDEEIIELASFHASENDNDNKTKDDVISISDDSTTSLPQEITNKHKHDTSVNKMNDSFSTPVKDISQDLSIIEQDERPTYRRSKRIKRLYGEKDRNVDYWDKLPDEDLLQEFIEVSQKSSQHNNSKRKSSIINKNLIENSLLYNESTDDNGIDDIGDIKIHNDSDIEEVIDNDEIPMDEIEIEMEDVYVEENKSNDLSQQKQQAKDTTANGKGEYQLQSDNVSDKDKSTEPRSQKQLSFANGDDNEDKDLDIEKGEQAKVDLSKDINGFSPVIQEDSDSNSDSNSNSDGTDNKNREDVNSNSEKEEFDLEDSDDESEYHSDENSESYADSSDESFKISGNFDDTTQELENPKTKQRKSTSKTPAKETETSKQNNSKAKVKGKDISKSEPKKPKRVVISKKEKSTTPLENLFDNTDDNLEYDEKHIEKIENEPSTHLLEPKKLKKKNTISKKTKSKTSEQKQIETKQLEPTKRKFEEPNTSPIRFLDSLKNLQRKRKKLFKPNILDMSFETAEVLSSPNKFLSSKNETGVNVKDDSSPEKTHKQNNVTIEEKVVDEKVKIDKEDTPTGTKINSLSKTKNLKNSNTVIDLNDNDMVVDPDEELVPGITKSSGLPNSNVPTTDANNSTKEESSILKDLDSFVSFEKSPKPKIAEIQATSTSNNSRISFVVESESSDNDSYSNYIQDIKQIDDEISKVMLEDSESHSLTKVDTNEKEESIMNDSNYEDSEKKSIKEQDPDGMDIDASDLLVEEEEEAEEELIIDSTEELQSNQKASPIRNSSEMTAGNDRSLEEITGPNDSPPKVKNTDTYYSPDNTKELPSKSLTKASESDITKNQEITKEFKETKVESSAITKKHSLEIDEKHYPDVLGIGGLATSPLGMNSSLTEIHRLNNNNNSSNENDNDNGGVEEEEEEEKKKLQPSLKWQSRSMSQFIEQTKFLESSANELKDLACSEYDLHDDVTGDLTKFIAEMPEEEEEMTIKQWIEHCAANCKDIVTQSCTEINDFILEEYDRAIKMIEEMPTED
Protein: Histone H2B 1 (P04255)
Organism: Caenorhabditis elegans
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Pharynx and intestine in excess protein 1
- Histone H4
- Histone H2A
- Tubulin beta-2 chain
- Protein unc-119
- Histone H3
Sequence:
MPPKPSAKGAKKAAKTVTKPKDGKKRRHARKESYSVYIYRVLKQVHPDTGVSSKAMSIMNSFVNDVFERIAAEASRLAHYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK
Protein: 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (EC 2.5.1.78) (Q6FXA8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Riboflavin synthase
- 3,4-dihydroxy-2-butanone 4-phosphate synthase
- Riboflavin kinase
- GTP cyclohydrolase II
- 2,5-diamino-6-ribosylamino-4
- Inosine-5'-monophosphate dehydrogenase
- Phosphomannomutase
- Folic acid synthesis protein fol1
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
Sequence:
MAVKGLGQLDQNYDGSKLRVGIIHARWNRVIIDALVKGAIDRMLSLGVKEENIIVETVPGSFELPYGSKRFAEKQAKKGEPLDVVIPIGVLIKGSTMHFEYISDSTTQAIMNLQDKINIPVIFGLLTCLTEEQALARAGIDEGKTMHNHGEDWGAAAVEMATKFGANA
Protein: Polypeptide N-acetylgalactosaminyltransferase 9 (EC 2.4.1.41) (Polypeptide GalNAc transferase 9) (GalNAc-T9) (pp-GaNTase 9) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) (Q9HCQ5)
Organism: Homo sapiens (Human)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
Sequence:
MAVARKIRTLLTVNILVFVGIVLFSVYCRLQGRSQELVRIVSGDRRVRSRHAKVGTLGDREAILQRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGLAATLRDDGQEAEGKYEEYGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLPQVSVVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNSRREGLIRARLQGWKAATAPVVGFFDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYANAAHGYNWGLRCMYIIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMRVWQCGGSMEVLPCSRVAHIERTRKPYNNDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMSNPGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLTYGEVRNSKASAYCLDQGAEDGDRAILYPCHGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCLVDDGTGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRATGRCLEVEMSKDANFGLRLVVQRCSGQKWMIRNWIKHARH
Protein: Serine/threonine-protein kinase BSK1 (EC 2.7.11.1) (Brassinosteroid-signaling kinase 1) (Q944A7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Mediates signal transduction from BRI1 by functioning as substrate of BRI1. Functions as a positive regulator of plant immunity. May be involved in the regulation of pattern-triggered immunity (PTI) downstream of the flagellin receptor FLS2. Possesses kinase activity in vitro. Kinase activity is required for its function in innate immunity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18653891, ECO:0000269|PubMed:23532072}; Lipid-anchor {ECO:0000269|PubMed:23532072, ECO:0000305|PubMed:12912986}. Note=Plasma membrane localization is required for its function in innate immunity. {ECO:0000269|PubMed:23532072}.
Interaction partners:
- Serine/threonine-protein phosphatase BSU1
- Serine carboxypeptidase 24
- Protein BRASSINOSTEROID INSENSITIVE 1
- Shaggy-related protein kinase eta
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- BRI1 kinase inhibitor 1
- Protein BRASSINAZOLE-RESISTANT 2
- Protein BRASSINAZOLE-RESISTANT 1
- Shaggy-related protein kinase iota
- Serine/threonine-protein phosphatase BSL1
Sequence:
MGCCQSLFSGDNPLGKDGVQPQPLSQNNHGGATTADNGGSGGASGVGGGGGGGGIPSFSEFSFADLKAATNNFSSDNIVSESGEKAPNLVYKGRLQNRRWIAVKKFTKMAWPEPKQFAEEAWGVGKLRHNRLANLIGYCCDGDERLLVAEFMPNDTLAKHLFHWENQTIEWAMRLRVGYYIAEALDYCSTEGRPLYHDLNAYRVLFDEDGDPRLSCFGLMKNSRDGKSYSTNLAYTPPEYLRNGRVTPESVTYSFGTVLLDLLSGKHIPPSHALDMIRGKNIILLMDSHLEGKFSTEEATVVVELASQCLQYEPRERPNTKDLVATLAPLQTKSDVPSYVMLGIKKQEEAPSTPQRPLSPLGEACSRMDLTAIHQILVMTHYRDDEGTNELSFQEWTQQMKDMLDARKRGDQSFREKDFKTAIDCYSQFIDVGTMVSPTVFGRRSLCYLLCDQPDAALRDAMQAQCVYPDWPTAFYMQSVALAKLNMNTDAADMLNEAAQLEEKRQRGGRGS
Protein: Camelliol C synthase (EC 5.4.99.38) (Lupeol synthase 3) (AtLUP3) (P0C8Y0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts oxidosqualene to camelliol C. Minor production of achilleol and beta-amyrin.
Interaction partners:
- Squalene epoxidase 2, mitochondrial
- Squalene epoxidase 6
- Squalene epoxidase 5
- Squalene epoxidase 3
- Squalene epoxidase 1
- Squalene epoxidase 4
- Thalianol synthase 1
- Marneral synthase
- Seco-amyrin synthase
- Baruol synthase
Sequence:
MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIPPAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDFPQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRRRVPLPYEKPSTERRS
Protein: REST corepressor 2 (Q8IZ40)
Organism: Homo sapiens (Human)
Function: May act as a component of a corepressor complex that represses transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- Histone deacetylase 2
- Zinc finger MYM-type protein 2
- High mobility group protein 20A
Sequence:
MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL
Protein: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1) (Q9GZU7)
Organism: Homo sapiens (Human)
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:12721286}. Note=Colocalizes with RNA polymerase II.
Interaction partners:
- RE1-silencing transcription factor
- Cell division cycle-associated protein 3
- Myelin basic protein
- RNA polymerase II subunit A C-terminal domain phosphatase
- CTD small phosphatase-like protein
- Ubiquitin-like domain-containing CTD phosphatase 1
- General transcription factor IIF subunit 1
- NIF3-like protein 1
- Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
Protein: FI23527p1 (Zinc transporter 77C, isoform A) (Zinc transporter 77C, isoform B) (Q9VPE3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- LD23375p
- Zinc transporter 33D, isoform B
- Zinc/iron regulated transporter-related protein 42C.2
- FI18611p1
- Zinc transporter ZIP11
- Neuralized-like protein 2
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- IP18018p
- LD05335p
- RE54080p
Sequence:
MVKDILQRCKPIPLYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPSPALTKINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTLVHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLIGGYTLHQGSFLHLTPGGNVVLERPMSSNLDLSLTPMQRHLSKSRNDRQLREELETEVGSVYFATKRQGAVEMLRDVSSTIFVIVCAAIVYVAEDEQHTAKFIDPVLSIFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTLVTKFPEIISYHDLHIWQLAAHRYVATIHIQFQNPKLYLKIIEQVRSYFHDQGIGAVTIQPEFYPSTNKNASASLECLMQCQAVECIEKVCCRDSRTDLREVCDAPSGRKSSSPVKCAGNSHEHSRAKSKSCAELSAVVVEKPEELSAGQLLKGQDQQVAKSMPKLEETCVDATKEDTAELSGSPPGPTSSD
Protein: Tripartite motif containing 68 (E9PP83)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVG
Protein: Protein jagunal homolog 1 (Q4KM64)
Organism: Rattus norvegicus (Rat)
Function: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G protein subunit beta 1 like
Sequence:
MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK
Protein: Uncharacterized protein (Q586K6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- SURP motif domain-containing protein
- Uncharacterized protein
- Splicing factor 3A, putative
- Splicing factor 3B subunit 10
- Spliceosome-associated protein, putative
- Splicing factor 3B subunit 1, putative
- PHD finger-like domain-containing protein 5A
- RNA-binding protein, putative
- Sm protein G
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MSHVKAFDPAAQARCDPYYKRNHMGHVVCTLCDVCCSDDNNFIKHLAGKTHSLQLERLERSANREKRLAEEEELNKEAMRRAEQEKATRELLLQQTSAPHASSVTSFAPFGRPEFHYCTEHDPELYQTKVWLEFYFPQAVEGARPLHRWRSAREQEVEKPPNDDVVYLLVACEGYMTVGLKFPSKLPRTSSGLTSWGGYGNAGSDEEKGRYRCSWDPVKKLYELFFIIG
Protein: Cell division control protein 2 homolog 3 (EC 2.7.11.22) (P54666)
Organism: Trypanosoma brucei brucei
Function: Probably involved in the control of the cell cycle.
Interaction partners:
Sequence:
MTMLGALTGRQLSSGLKDQFDRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHPNIVNLLDVICADGKLYLIFEYVDHDLKKALEKRGGAFTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSIGCIFAELARGKVLFRGDSEIGQLFEIFQVLGTPMDAEGSWLGVSSLPDYRDVFPKWSGKPLTQVLPTLDGDAVDLLSQMLRYNPAERISAKAALQHPWFSDAMF
Protein: Uncharacterized protein (Q38BB8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYSDGTRKTMSELQRMAGATRMRIAEEGAQLETLSKATTRAQKLVDSMFNLFASGATHHERGELMRILTSEESDIDIGGVPPFPAALALANGQLPHVRTIRAAGNNRINDEVVIFLSQVIRFSAVPAQVELLDISDTKVTERGLLFVLEMILERDEPFTLIAKGLVSSEGFALAGDLTGVGERFRKVFEMVVLQRKSVIIF
Protein: Neurexin 1 (A0A0D9SF36)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
DLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEVALMKADLQGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDS
Protein: C-type polyheme cytochrome OmcC (Outer membrane c-type cytochrome C) (Polyheme membrane-associated cytochrome c) (Q749L1)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Function: Not involved in Fe(3+) reduction.
Subcellular location: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Uncharacterized protein
- Cytochrome c
- Cytochrome c
Sequence:
MSRKVTKYSAVLAVSLFAAALAGCGSENKEGTVGTGPGGVATVGDTACVQCHSAVVDPLTGESIITQYTRSFHYSKGVGCEGCHGGGAQHNGVGPLPFPLAGQSEAQIAARCASCHNGVIAPLSSSPNFVNGNHANPFGGEEAKENLCSRCHSHEGAIFGAQAGFTGDGNILRNAAYQPVYPQDPETFNVMTCATCHQHGGAQRQVFTQISTAGVPNSRRTVAWDPNRNSINDQYDLCTSCHTVNTMTGTLIGSGNVLQIFTSNAVGSGTKSVTTAPFYHNTRWFRTLPSTHYDFPESKTTASGTTIEGYVIRRNTANPCFDCHGHEFQTNTRRLAGADRPNTIFLDWGQSAHGGKLLQAKVAAAALASSGAAEVDDVMKAGATDATAPGWTHYNWDDTASRGACQRCHTSTGASNFLNNPAGYDRTGAGNSFTHLAGWTSSNKRSDQNELLYCWGCHTKAGTGELRNPGAITEVYPGINSTSTGTTGLDVTVSYPDIKGSNVCMGCHLGREVGDNIKAITDADGILGFVNSHYLTAGGQLFGTTGYEYATRSYANPAFFQHDKIGTAAAPGTGTNGPCAGCHMTTPTSHLFLPVTKDGTGAITAITSTACVTCHAGTFALTPEGLTAEEEEYVASLEALKAALAGKGILFFNAHPYFYRDTNANGIADPGETVSSNAFTNWAGVYGLALWQDVMGAAFNANLLIHDPGGYAHNRFYSKRLIWDSIDFIFDGVLNNDVTAAIDAQVTAARLDSATATAAKAYLGATRP
Protein: ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33 homolog) (Protein athos) (Q9VL25)
Organism: Drosophila melanogaster (Fruit fly)
Function: Part of a translational control module, also containing pths/DDX47 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:35413237}.
Interaction partners:
- Pre-mRNA-splicing factor syf1 homolog
- Pre-mRNA-processing factor 17
- Cwc25
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Cell division cycle 5, isoform A
- Pre-mRNA-splicing factor CWC22 homolog
- Splicing factor YJU2
- Pre-mRNA-processing-splicing factor 8
- 116 kDa U5 small nuclear ribonucleoprotein component
- Protein crooked neck
Sequence:
MDSKYFATSRNDAVGPSPVKFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDIDCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVPFVKNIPTR
Protein: LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) (Q6P1M3)
Organism: Homo sapiens (Human)
Function: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
Interaction partners:
- Protein kinase C iota type
- Protein kinase C zeta type
- Lethal
- Disks large homolog 4
- Partitioning defective 6 homolog beta
- Protein scribble homolog
- Partitioning defective 6 homolog alpha
- Partitioning defective 6 homolog gamma
- Disks large homolog 1
- Ubiquitin-protein ligase E3A
Sequence:
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAETKNHRPGNGAGPKKAPSRARNSGTQSDGEEKQPGLVMERALLSDERVLKEIQSTLEGDRGSGNWRSHRAAVGCSLSNGGAE
Protein: Rho guanine nucleotide exchange factor gef3 (O59679)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Septum.
Interaction partners:
- GTP-binding protein rho4
- GTP-binding protein rho3
- Protein hob3
- Rho guanine nucleotide exchange factor gef2
- GTP-binding protein rho5
- Exocyst complex component sec8
- Septin ring organizing protein mid2
- Rho1 guanine nucleotide exchange factor 3
- Septin homolog spn1
- Glucan endo-1,3-alpha-glucosidase agn1
Sequence:
MSNPRMFQSRGKRVVSDSLPIANSTHTLEDTLKLRPDWTIALSQHETETRSTRTSCSTTTESTIAMRSKQKAIISVLEEFRDSEAAYVHDLHVAQRYYADRLSDRVKKSEWKDVFEIFLVLCKQASLFEIEMHKSLNDEINYILDDQDACLKPKPSVAQLFLSWLPKLSAVYGRYCVIQENIGKKVEKWMKNSSISEYLQECDSMAKIESNSWNLDSFLVKPVQRFLKYPLLLNQLYRSASLGIISDYVLLGEACHKSEIASQRMNELKRRRDIIITALDSVSNSQEVLLLSTDSIDKKIAKLQNSTNIFYVPEHEPILAFVHQLSSSYTNLLNLRSAICDWLKFSRYHYLKFFTFVEAYSVFCKDTKSADKWALISVALDNIAKGAVLRLTEQCQTSVLRPISNGILFFRNPLCVTDVWIKKATAFSKRRQSQVFEEDLESFPLLSNCLLEELPLFLEMARNVTDECILAFAQIQATFYDTIQKVLEPVVAKFNLTDHQDIPSIESIMDFTSLRSSMESSPKSK
Protein: Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) (Delta crystallin II) (Delta-2 crystallin) (P24058)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Function: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein also functions as an enzymatically active argininosuccinate lyase.
Interaction partners:
Sequence:
MASEARGDKLWGGRFSGSTDPIMEKLNSSIAYDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAGNPLDIDREMLRSELEFASISLNSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFGFLTLSDAFSTGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKALTPEMLATDLALYLVRKGVPFRQAHTASGKAVHLAETKGITINKLSLEDLKSISPQFSSDVSQVFNFVNSVEQYTALAGTAKSSVTTQIEQLRELMKKQKEQA
Protein: Papain-like cysteine peptidase (DUF1796) (Q38F22)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQRCKLLRSIDFSGVRLPRKYISMGGWCGPALLLGKVGLRTEAYPFDFSRCTLDGILHFIQNGFSCGFYPPEPPPYKPECVGIWVLFRGLHTAFAHFDLNDPKIKAQFSRKMARWNNIIDKPDMPVTFFRSIVSRDPLEEVHLMPAVEAAIAARNPSLDFRIVMIAHDQGLVARSVELKPLSKRISLWVLTYTRDDTFTLFDRSQEAYTDIVLHSVNEENWPLDPTTVPQPVGLTESEADYQQCVLRKADGTDVSFESLTASGFPWRSHTNLSLIDGVASVGGTCTGIGSTKCVGGRCAFCSNTDYHKAGRPFHSERPFTIEEDELILVHLYRILTGGDKVEAVEDLAHQMKRGAFEVICRIQHLTNSSVKIMDYSSDGA