wanglab/gogpt-training-data huggingface dataset:
Protein: Secreted frizzled-related protein 4 (sFRP-4) (DDC-4 protein) (Q9JLS4)
Organism: Rattus norvegicus (Rat)
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis (By similarity). May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q6FHJ7}.
Interaction partners:
- Protein Wnt
- Protein Wnt
- Protein Wnt-4
- Protein Wnt
- Protein Wnt
- Protein Wnt-5a
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
Sequence:
MLLSILVALCLCVRLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERSFDADCKHLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYERRSRMMLLENCLVEKWRDQLSRRSTQWEERLQEQQRTTQDKKQIASRTSRSNPPKPKGRSPASKPASPKKNIKARSAPKKSNPKKSTS
Protein: ROBO3 protein (Q96HH0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSQSRSQSQRPGQKRREEPR
Protein: Peptidyl-prolyl cis-trans isomerase CYP18-4 (PPIase CYP18-4) (EC 5.2.1.8) (Cyclophilin of 18 kDa 4) (Cyclophilin-1) (Rotamase cyclophilin-5) (Q42406)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- UPF0235 protein At5g63440
- Cysteine proteinase RD21A
- At1g31300/T19E23_12
- Probable cysteine protease RD21B
- Probable cysteine protease RD21C
- At1g09850
- Large ribosomal subunit protein uL2x
- Pre-mRNA-splicing factor SYF2
- Tetratricopeptide repeat
- Pre-mRNA splicing factor SR-like 1
Sequence:
MSNPRVFFDMSLSGTPIGRIEMELFADTTPNTAENFRALCTGEKGMGKLGKPLHFKGSIFHRVIPGFMCQGGDFTAKNGTGGESIYGAKFKDENFIKKHTGAGILSMANSGPNTNGSQFFICTDKTSWLDGKHVVFGQVVKGLDVVKAIEKVGSDSGKTSKVVTITDCGQLS
Protein: LIM domain 7b (LIM domain only protein 7b (EC 3.4.19.12)) (F6NN15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Zinc finger E-box-binding homeobox 2b.
Sequence:
MEWRQQSSVSCELAFQEAQRWIEEVTKKSFGSKSFRVALEDGVLLCDLINTLKPGIIKRLNRLSTPIAGLDNVNVFLKACKKLGLNEAQLFHPGDLQDVSTRVTVRREETNRRLKNVLITIYWLGRKAQSDPFYTGPQLNLKAFEGLLGIALSKALEELAQSRLSVRDSGYSEGWFSDREELYSVKQPSYRREDSVESLDSVESRALSVASDLTLRAGSEGCCSDAEAEHFFRMAESSKSGAPIREKAHVPAVLRKKRQDYQQGSRSYAGHLTSESGHGLCHDLPPASAFLQWASSYQSDSDSDSDRPEADPEQDDLASRRFRSVTSAAPVNFAIPSKPQGPRVTAYVTPNAGKSWLTLSDATRSNQSLSSIPSENGRTDSDSANLEEEFLQRVLSNGTSDSDEDRGYADPVLDDLYARRVLVSEHQTSINANSDKFLPKFWTPEEDLHVRKIRLGSQRRPWYKKMQGLRSKSMGDITLEPIPQESDNSSSFDSLGPLHVHQRSDEELSLDPSALQRVQYEQLQHIRQRMKENEAKWHEDLSRWKSRRRSANSDLHKKLEEREQIELITTAGGASGIRTAHLTGVPEESSSMPGPMSDAGSSVSSSGWSTSASGLANGATSALTRGTVVETSDSAQKCTGVLSSHPSAVVSEQTSQSSLTAVDAESDEQQGPDFSLRSSLLESFYAGGARMSATLPRGFRRSEGCSRLSTGVTPRPFGAKPSKMPTLPKVYSVDDSHKSLISGHRDHSAVPSFLGGQGKVTASAGKGHSRSSTHPINPKEEETRDGRSSAPPMNSYATKVTMTTSIIQTSPPAISEIRDVKVGQSEMRVCLNQKPNSGRDFGFKAHWDSVGAYVKSVQAGSPAELYGLLMGDEIVALGGRRVDEMNYEQFKSSMETAQQNGTLLMDIRRHGQNDWGSGQPSLPYQSHKIINLTSATSTLIGRPEHFVPINTSSNSSVETVGKTQVNGQPANGVLSKMMNGSIQDNAAAVRNKGGSESDISDLQVPSISTTSSSWSWDHEEERRRQEKWQMEQERLLQEKYRRDQEKLEEEWRRAQQEVYGEEYCGLEEQKTLDVLSNGNPAPHNSPPFYNQSSATFSVTFNENVAAAQNRQACVQTAAGHQSIKAEDKCDSPTKTLCSEESYGFAKLTVSDRTKSKSTPALEALHKQDAKEGCSKKKGQLSQAEKERLQILDEMRKKTPLHTDSSWIRQRNASINKETITVGTSIRRYESMDNLHTTNSWSRQSYTSGLSSRPHSALGSSGSYRSGRSSLGPGSAIFSTGVKLNSNTTTPEPPGLESRPNSQQQGRLVSGRRMCSRCEQPLGKGAAMVIDSLELCFHIGCFKCVSCRTELGRGPESGAQVRVRHRQLFCNTCYCRIRVCSSISK
Protein: P-type Cu(+) transporter (EC 7.2.2.8) (A0A669KB88)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004166}. Membrane {ECO:0000256|RuleBase:RU362081}.
Interaction partners:
Sequence:
MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI
Protein: Pre-mRNA-processing factor 19 (EC 2.3.2.27) (O77325)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Pre-mRNA-splicing factor PRP46, putative
- Pre-mRNA-splicing factor CWF7, putative
- Pre-mRNA-splicing factor SYF1, putative
- Pre-mRNA-splicing factor CEF1, putative
- Pre-mRNA-splicing factor CLF1, putative
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor RBM22 homolog
- Pre-mRNA-splicing factor ISY1, putative
- Small nuclear ribonucleoprotein E
- CWC16 domain-containing protein, putative
Sequence:
MSIICTISGQTPEEPVISKTGYIFEKRLIEKHIINYGICPVSGEVLTLEDLYPIKNEKIVKPRPITASSIPGLLSIFQTEWDSIISEMFSLRTHVNDIRNELSHSLYQYDAATRVIAKLLKEKNGYKEEIENLKKQIFQLKSSNDLDIYEIGLNEELLEKMQNVAKDLLINRKKRKIDNVCSVEQWKDFKNTNEFNIHSSTIPGVTCITLDVNKYKYNYNDDHMKHNFFSGGNDGNVYYVSLNDNKILSKLQGHLKKVNSIISHPSNFICITASNDKTIRIWKGDDNNVHHNDNGDSDSDNNNNNNDNDGSHLNNNEYIYDNYQFVSAHVITKHKDHVTSLALHPLENYFISSSKDSMWILHDLETAKTIKTSKDNPSSFKHLAIHPDGMMFGIAAQDSNIHIYDIKSQEYKATLNGHTKSLNCLSFSENGYYLASSSKDNTVKLWDLRKAQSFQTITLNETPNFISFDYSGKYLSIAVENDIQIYNFETKNQANLIKTLSSHTDIVTQTCFGSTTSYILSSSMDKTIKLWN
Protein: phosphoinositide phospholipase C (EC 3.1.4.11) (Q8BXH1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
YNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAALGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFL
Protein: Chloride intracellular channel protein 4 (mc3s5/mtCLIC) (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Q9QYB1)
Organism: Mus musculus (Mouse)
Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3 (By similarity). May play a role in angiogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y696}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Y696}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y696}. Nucleus {ECO:0000250|UniProtKB:Q9Y696}. Cell membrane {ECO:0000250|UniProtKB:Q9Y696}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y696}. Mitochondrion {ECO:0000269|PubMed:10593946, ECO:0000269|PubMed:17636002}. Cell junction {ECO:0000250|UniProtKB:Q9Y696}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Y696, ECO:0000250|UniProtKB:Q9Z0W7}.
Interaction partners:
Sequence:
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
Protein: 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) (EC 2.2.1.7) (Protein CLOROPLASTOS ALTERADOS 1) (Q38854)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP). Is a limiting enzyme for plastidic isoprenoid biosynthesis and essential for chloroplast development.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:18236010}.
Interaction partners:
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
- Phytoene synthase 1, chloroplastic
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic
- Hydroxymethylglutaryl-CoA synthase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial)
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
Sequence:
MASSAFAFPSYIITKGGLSTDSCKSTSLSSSRSLVTDLPSPCLKPNNNSHSNRRAKVCASLAEKGEYYSNRPPTPLLDTINYPIHMKNLSVKELKQLSDELRSDVIFNVSKTGGHLGSSLGVVELTVALHYIFNTPQDKILWDVGHQSYPHKILTGRRGKMPTMRQTNGLSGFTKRGESEHDCFGTGHSSTTISAGLGMAVGRDLKGKNNNVVAVIGDGAMTAGQAYEAMNNAGYLDSDMIVILNDNKQVSLPTATLDGPSPPVGALSSALSRLQSNPALRELREVAKGMTKQIGGPMHQLAAKVDEYARGMISGTGSSLFEELGLYYIGPVDGHNIDDLVAILKEVKSTRTTGPVLIHVVTEKGRGYPYAERADDKYHGVVKFDPATGRQFKTTNKTQSYTTYFAEALVAEAEVDKDVVAIHAAMGGGTGLNLFQRRFPTRCFDVGIAEQHAVTFAAGLACEGLKPFCAIYSSFMQRAYDQVVHDVDLQKLPVRFAMDRAGLVGADGPTHCGAFDVTFMACLPNMIVMAPSDEADLFNMVATAVAIDDRPSCFRYPRGNGIGVALPPGNKGVPIEIGKGRILKEGERVALLGYGSAVQSCLGAAVMLEERGLNVTVADARFCKPLDRALIRSLAKSHEVLITVEEGSIGGFGSHVVQFLALDGLLDGKLKWRPMVLPDRYIDHGAPADQLAEAGLMPSHIAATALNLIGAPREALF
Protein: Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline phytoceramidase) (aPHC) (Q9D099)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (By similarity). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NUN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUN7}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NUN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUN7}.
Interaction partners:
- Neutral ceramidase
- Acid ceramidase
- Ceramide synthase 2
- Ceramide synthase 3
- Ceramide synthase 4
- Sphingosine kinase 2
- Ceramide synthase 6
- Ceramide synthase 5
- Sphingolipid delta
- Sphingosine kinase 1
Sequence:
MAPAVDRKGYWGPTTSTLDWCEENYVVTLFVAEFWNTVSNLIMIIPPIFGAIQGIRDRLEKRYIAAYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKTKSSINYHLLFTLFLYSLTVTTIYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLTVFLLGFLLWNIDNIFCDSLRNFRKRVPPVLGVTTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPAVMFEPQRKH
Protein: Uncharacterized protein ycf70 (ORF89) (Q6ENI8)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MVYGYGKSNMPHPNRKRKGTDTQYDYWEELLVMVSGLYALFCVFLVLFIFFDSFKQESNKLELSGKEEKKKLNGENRLSRDIQNLLYIK
Protein: Somatotropin-1 (Growth hormone 1) (P09538)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MGQVFLLMPVLLVSCFLSQGAAIENQRLFNIAVSRVQHLHLLAQKMFNDFDGTLLPDERRQLNKIFLLDFCNSDSIVSPVDKHETQKSSVLKLLHISFRLIESWEYPSQTLIISNSLMVRNANQISEKLSDLKVGINLLITGSQDGVLSLDDNDSQQLPPYGNYYQNLGGDGNVRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL
Protein: Cytochrome C oxidase assembly protein, putative (Q38BT4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004243}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004243}; Intermembrane side {ECO:0000256|ARBA:ARBA00004243}.
Interaction partners:
- Protoheme IX farnesyltransferase, mitochondrial
- Cytochrome oxidase assembly protein, putative
- Cytochrome c oxidase copper chaperone, putative
- Cytochrome C oxidase subunit VI, putative
- SURF1-like protein
- Cytochrome c
Sequence:
MLRSPWTMLCGVGPPGLAPKRKPKIRIESGYERENQKYYEERGHFFSAFASISILSLGCTFLFVPLYRMYCAPTGRGADPKFYTPQAQRDREQLNEMYPVPKKLLKVRFLSDVGNTMPIAFVPLQKEVEVLIGEPALAFYSAYNRSNRTLLGVSSYTIAPPEATNYLNKIQCFCFEEQRFKPHELVEMPVFFYIDRDFLNDPMVNWLDEVIVNYTFFNLEKTKDIIFRSNLA
Protein: CIA6 (F6LJD1)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Interaction partners:
Sequence:
MADPELLAWCRKHGVEFGGIQAAYVDEGWRGVVATRDLAPGDTVLRVPGRLLMTTRSARADPALAAALSRLAASPDPDDVAAAAALTPHQLLATHLLHEVSKGPESFWHPYLQQLPRSYTSLAHFSADDAAALQLQLAQDVAAAAAERAREEWQGALPLLRALGLPKRFALLRSWLWAASTLHSRTMFLPWCPAGALTPFGDLHNYAPPPPPYVPQLGVAEDRTAAESAAAADEVAAAGSVAAASASGSVYGAEGATGATCAKDASTGAPGVGGACCDNRGSIGAAAKVQEGGSVGMQDGPDQGCCMALELLQLGADDPGKSRCHGANGVLGRAVEPRAAVASPAEASAQSNAPGPAELRPPGMLADVSAGAEGAEPAAAHEAEDADAIAGDGSWDEARQQYVIVVRRRVAAGQQVLLCYGRHTNLELLEHYGFVMQDNPHDTAPLDAALLPVPDSARYSAGAPPLPPDECFVHGGSPQAPCNTDNTGDGSSGCGAPSWSLLHFLRYCAATPAERRTQGHRLAAGESISEQGDRIALGWLRAACMRQLEDLPTSLAQDLEELQRNSQSDSNSNIQSRSHSQSQEEGPAQRSASQLGAGDRAAVPAPQAHDRQGAAGTTEAAQCEGTQQAAAAPAAAVAVALSDGFTCAGLALQWRVTYKRALHAAISRVDALLGAPTAEGAVAGHSLEALLQMQRQGRK
Protein: Rhamnogalacturonan I rhamnosyltransferase 1 (EC 2.4.1.351) (O-fucosyltransferase 34) (O-FucT-34) (O-fucosyltransferase family protein) (Q4V398)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glycosyltransferase involved in the formation of rhamnogalacturonan I (RG-I) oligosaccharides in the seed coat mucilage, which is a specialized cell wall with abundant RG-I. Transfers the rhamnose residue from UDP-beta-L-rhamnose to RG-I oligosaccharides. Prefers RG-I oligosaccharides with a degree of polymerization of 5 or larger than 5. Does not act on oligosaccharides with a degree of polymerization of 4 or smaller than 4. Does not require metal ions for its activity.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:30082766}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Hexosyltransferase GAUT11
- Probable galacturonosyltransferase 7
- Heavy metal-associated isoprenylated plant protein 20
- Probable pectin methylesterase CGR3
- Nudix hydrolase 9
- Gamma-glutamylcyclotransferase 2-3
- UDP-URONIC ACID TRANSPORTER 1
- O-fucosyltransferase 23
- Galactan beta-1,4-galactosyltransferase GALS3
- At5g42440
Sequence:
MCKMEKFLYHRKLWEMNVKLLGESKVEKLKNSFVSRPRMSLWMIRAVTVLLLWSCFVHLMALGEMWGPRLFKGWPSCFNHHQLSTAAEMTSLPTKIALPPKRVYVNNGYLMVSCNGGLNQMRAAICDMVTVARYMNVTLIVPELDKTSFWNDPSEFKDIFDVDHFISSLRDEVRILKELPPRLKKRVELGVYHEMPPISWSNMSYYQNQILPLVKKHKVLHLNRTDTRLANNGLPVEVQKLRCRVNFNGLKFTPQIEELGRRVVKILREKGPFLVLHLRYEMDMLAFSGCSHGCNPEEEEELTRMRYAYPWWKEKVINSELKRKDGLCPLTPEETALTLTALGIDRNVQIYIAAGEIYGGQRRMKALTDAFPNVVRKETLLESSDLDFCRNHSSQMAALDYLVALESDIFVPTNDGNMARVVEGHRRFLGFKKTIQLNRRFLVKLIDEYTEGLLSWDVFSSTVKAFHSTRMGSPKRRLVIPNRPKEEDYFYANPQECLQLLDEPLRVI
Protein: Nicotinamide riboside kinase (NRK) (NmR-K) (EC 2.7.1.22) (Nicotinic acid riboside kinase) (EC 2.7.1.173) (Ribosylnicotinamide kinase) (RNK) (Ribosylnicotinic acid kinase) (Q9C0W1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
Interaction partners:
- Putative glutamine-dependent NAD
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Probable nicotinate phosphoribosyltransferase
- Putative purine nucleoside phosphorylase
- IMP-specific 5'-nucleotidase 1
- Putative nicotinamide mononucleotide adenylyltransferase
- NAD-capped RNA hydrolase
- Uncharacterized protein C1683.06c
- Alkaline phosphatase
Sequence:
MTRKTIIVGVSGASCSGKSTLCQLLHAIFEGSSLVHEDDFYKTDAEIPVKNGIADWDCQESLNLDAFLENLHYIRDHGVLPTHLRNRENKNVAPEALIEYADIIKEFKAPAIPTLEQHLVFVDGFMMYVNEDLINAFDIRLMLVTDFDTLKRRREARTGYITLEGFWQDPPHYFENYVWPGYVHGHSHLFVNGDVTGKLLDKRIQLSPSSKMSVRDNVQWAINSILNALQ
Protein: Ribose-phosphate pyrophosphokinase, putative (EC 2.7.6.1) (Q57Z76)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transketolase
- ribose-phosphate diphosphokinase
- ribose-phosphate diphosphokinase
- ribose-phosphate diphosphokinase
- Ribose 5-phosphate isomerase, putative
- Ribokinase
- Orotidine 5'-phosphate decarboxylase
- NUDIX hydrolase, conserved
- inorganic diphosphatase
- inorganic diphosphatase
Sequence:
MRTGKGRSEGQAFHRRLLSEYNTDFTLNNYVAYFELKPIAKELEQLCKEIERVREIEARAAAADTSTASETEDVFANQPEAMKLPQTGGSSLSPKRSLDELLKRRSELEVKFFKDIQLSFTKVKQYQQCLEADLLAGVEELKNMSEEEIRARPEEHIPKLYVKTQAILQYRALNLAALRKILKKFMQRCARDSLELQKHLLMVDKVISCSTISQPANDLRRVALDLIAFYGTVFRLTYEETVEVLTRYEHRAGVNVRRILPHSDTFFFTLRLPHQERHGDFAVCILPGSTSLFCEKMICEVLQCNRYPPCCGQYPNGEVNVVLPRSVRGDDLFVLQSLVRCDRVGLSHSGTLMELALMIHAARASSAARITAVIPYISFTESVSSMAAVAEILESMGCQHVITVDMPIDQVEGMFSVPLELISARYEFVQYIANQLTAEGHDFRNITVVAPNGAGVHRAKNFADALMQYKKLSPDEQFVPLCTAVRRQVYRGLQDTVLNINHCGANVGSTRAFEQALLQQEQGICAIQDDGDTTITSEGIDLVGDVQGKLCIVVDTSVDEATEICQTACKLREEGASRIILIATHFIISGRAVERLIESPIDLIVVTDSVEHDEVFKNPHIARRLRVLPIAPLLARAIEKLHTENSLTTLFEK
Protein: Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2) (P07093)
Organism: Homo sapiens (Human)
Function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Prothrombin
- Urokinase-type plasminogen activator
- Sorting nexin-1
- Sorting nexin-4
- Vacuolar protein sorting-associated protein 29
- Sorting nexin-5
- Tissue-type plasminogen activator
- Sorting nexin-2
- Vacuolar protein sorting-associated protein 26A
- Sorting nexin-6
Sequence:
MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
Protein: Low affinity inorganic phosphate transporter 4 (PhPT4) (PhPht1;4) (Arbuscular mycorrhiza-induced phosphate transporter PT4) (AM-induced phosphate transporter PT4) (H(+)/Pi cotransporter PT4) (Protein Pi TRANSPORTER DOWN-REGULATED) (B2CPI6)
Organism: Petunia hybrida (Petunia)
Function: Low-affinity transporter for external inorganic phosphate (Pi) probably involved in the acquisition of phosphate released by arbuscular mycorrhizal (AM) fungi (e.g. Rhizophagus irregularis and Glomus intraradices) during AM symbiosis (Probable). Acts as a Pi-sensing machinery at the root tip level, independently of AM fungi, involved in the regulation of early root branching and lateral roots formation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8GSG4}; Multi-pass membrane protein {ECO:0000255}. Note=Present on the periarbuscular membrane in cells containing arbuscules during arbuscular mycorrhizal (AM) symbiosis with AM fungi. {ECO:0000250|UniProtKB:Q8GSG4}.
Interaction partners:
Sequence:
MASDNLVVLNALDTARTQWYHVTAVIIAGMGFFTDAYDLFCISTVSKLLGRLYYYDPSTKAPGKLPHMANNWVIGVALVGTLSGQLVFGWLGDKLGRKKVYGLTLILMVICALCSGLSLGYSPKSVIGTLCFFRFWLGFGIGGDYPLSATIMSEYANKSTRGAFIAAVFAMQGVGIIFAGLVSMTISKVFLMNFEGKPFNVDEVLSTEPEADYVWRIVLMLGALPALLTYYWRMKMPETGRYTAIIEGNAKQAAIDMGKVLDIEIQAEGDKLAQFKAANEYSLLSNEFFQRHGLHLIGTMSTWFLLDIAFYSQNLTQKDIFPVMGLTSKANTISALREMFETSRAMFVIALFGTFPGYWFTVFFIEKIGRFKIQLVGFFMMSVFMAIIGVKYDYLRNKEHKWTFAALYGLTFFFANFGPNSTTFVLPAELFPTRVRSTCHALSAALGKAGAMISAFGIQQYTQDQDVRKIKTAMLLLAFTNMVGFCCTFLVTETKGRSLEEISGEDGRQNETQMKTTRPVSGHPDDGWE
Protein: Protein preY, mitochondrial (PIGY upstream reading frame protein) (Q96I23)
Organism: Homo sapiens (Human)
Function: In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis, by stabilizing its components, such as COQ5, and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly, by stabilizing complex I assembly factors, such as NDUFAF5.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:35614220}.
Interaction partners:
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
Sequence:
MLSGARCRLASALRGTRAPPSAVARRCLHASGSRPLADRGKKTEEPPRDFDPALLEFLVCPLSKKPLRYEASTNELINEELGIAYPIIDGIPNMIPQAARMTRQSKKQEEVEQR