wanglab/gogpt-training-data huggingface dataset:
Protein: Tegument protein VP22 (Gene 11 protein) (P28960)
Organism: Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Function: Tegument protein that plays different roles during the time course of infection (By similarity). Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection (By similarity). Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins (By similarity). Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network (By similarity). Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (By similarity).
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P10233}. Host cytoplasm {ECO:0000250|UniProtKB:P10233}. Host nucleus {ECO:0000250|UniProtKB:P10233}. Host Golgi apparatus {ECO:0000250|UniProtKB:P10233}. Note=One of the most abundant tegument protein (about 2000 copies per virion). Localizes in the cytoplasm at 8 hours postinfection and in the nucleus at 16 hours postinfection. During virion morphogenesis, this protein probably accumulates at the trans-Golgi where secondary envelopment occurs. {ECO:0000250|UniProtKB:P10233}.
Interaction partners:
Sequence:
MSDTWRRRRSGCNDANATEELVYSTVRSDHRQRRPSRGTFVMRENDLYDKQSVSKENDLYESASPNDDKVYTRRGMSTAAHYRDSEHIYETCEGDEFYDACEYSLIGGGKLSTSNGRQSPAKAQPPPRGAAAAPPPRVPTRPPTRAAATSTTPRQQDCAPKQRASPGVNSIKSGKGLAFSGTPKTPKSQWYGATHLFNKNVFCAAVSRVAAAHASDAASALWDLNPPKTNEDLDRFLKAAAIRILVCEGAQLLEVANSTMESTPDGYAAAGPNGYDRRPRTASRRRSLKCKPPADDFFDDTNSG
Protein: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) (Q9QZH6)
Organism: Mus musculus (Mouse)
Function: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BQ95}. Nucleus {ECO:0000250|UniProtKB:Q9BQ95}. Mitochondrion {ECO:0000250|UniProtKB:Q9BQ95}.
Interaction partners:
- Complex I intermediate-associated protein 30, mitochondrial
- Complex I assembly factor TMEM126B, mitochondrial
- TNF receptor-associated factor 6
- Complex I assembly factor ACAD9, mitochondrial
- Complex I assembly factor TIMMDC1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
Sequence:
MSWVQVNLLVRSLSRGWGGLCRPALSGTPFAQVSLQALRGLHCSAATHKDEPWLVPRPPEPQRKPIKVPAMHEDLFKPSGNRERDKASFLNAVRSFGAHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFVHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSDSTGMEDPTQPHIVGIQSPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVEEIPEEWELYYPQKLDLEYSRSGWDDYEFDVDEVTEGPVFAMCMAGAHDQATLIKWIQGLQETNPTLAQIPVVFRLARSTGELLTTSRLEGQSPPHSPPKGPEEDDETIQAEQQQGQS
Protein: Putative uncharacterized protein VPS65 (O13554)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRHCIIFIVCISIVEIRTVHIEFIKEIVVIFRIVDHFSPFMLPCLLSHCKDGDTIIFVCQSVMKVRNISLWNKLVLVRHCVLLCAFLLSFFNVLHSIISICRIF
Protein: Nicotinamidase (EC 3.5.1.19) (Nicotinamide deamidase) (NAMase) (Q9USS0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Peroxisome {ECO:0000250|UniProtKB:P53184}.
Interaction partners:
- Probable nicotinate phosphoribosyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- NAD-dependent histone deacetylase sir2
- Putative glutamine-dependent NAD
- Multifunctional tryptophan biosynthesis protein
Sequence:
MSFHPALIIVDVQNDFVHPVYISSGESALEVVPVINRLLENDYKWDTVIATKDVHPKDHLSFTTSHSSTPKPSGTVVNIEAYGHVYKQTLWNSHCVENTPGCEFPDSLNGDRIEFVIPKGSDRLVESYSGFYDAIGRDNGLKAILDKKGITDVFIAGVATDICVKETALHARHWYNTYIISEAVKGSSTESHNQAIKDFRDAKIEVISEKDPILQSVRKV
Protein: Ammonium transporter 3 (Q8MXY0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}. Endosome membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}.
Interaction partners:
- Hybrid signal transduction histidine kinase C
- Acetyl-CoA hydrolase
- Rhesus-like glycoprotein B
- Type-1 glutamine synthetase 1
- Cytochrome b5 reductase
- Cytochrome b5 heme-binding domain-containing protein
Sequence:
MEQFSTSSSESSDSSSEYSLEFYMDTSWVLDAANLVFFMQAGFGMLEAGMVRAKNTKSILLKNLINTAICAISYYCVGHSFAYGKVNPNSFVGFGNFFLMDYTHYAYWMIQWAYAATATTIATGAMAERLQLHCYILFTLVQTILIYPFVAHWIWSQNGWLFDLGIVDFAGGAVIHIVAGITGACGSFLLGPRIGRFNQESGKPKNLPGHSVVLMSLGAMILWYSWYGYTAGASLGMTRSRVLPASRVSVVVTLSGATGLITVLGIGKIFNGHYDLVKGINGLIAGLVSSTSSCAYIEPWAAIIIGFIGGIVYWFSSWALLNWLRLDDPVDSTAIHLFGGCWSLISVAFFATHGRVRNPDIILPGGIFYGGGISLLWVQLVGMVLAILWAGFLSGIFFFTMDYFGKLRVDVDTELAGLDNSNHGGSAYIFD
Protein: DUF724 domain-containing protein 9 (AtDUF9) (Q9FFA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the polar growth of plant cells via transportation of RNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:19795213}.
Interaction partners:
Sequence:
MFSPGTTVEVSSKINNKEVVWVPAVVIKEFKEDDEYKYIVRVYDKSFSCKGNKAARLNKTVDLCSLRPTPPSISVEEYQLKEYVEVFHDGMGWRQGRVMKIQERVMLSQGRVMVSQGRVMGNLSQKCYIVLLEATKKQISFKQSDLRPLQVWEDGVWKMLQTRESSLTQGSGDETSDSVRNANESDPPVTPRPGITTPPLKQIEAETQRKTLPRNQNASVNDSTRENENSEDINRKRKREESLCSDASVEDTTMTLPFEKKLSIWKTLESVETVPQSPHFSPLVETREDCREMSAVGMMLTFPCLLEEVKSLQHDNSISSLISLSNNFCELEKHGFNVKAPQSRISKLLSLRGKQSMKMDELKGAEKVTAEKESIKIENERKILELQRLNEEVDKEIAQSKSCAAKIVQQLEDVELQFQTTASAPW
Protein: Cytochrome P450 705A12 (EC 1.14.-.-) (Q9FH67)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in hydroxylation of the triterpene marneral.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Marneral synthase
- Thalianol synthase 1
- 2-oxoglutarate
- Small ribosomal subunit protein eS27w
- Disease resistance protein
- At2g22880
- Similar to part of disease resistance protein domain family protein)
- Homeobox-leucine zipper protein-like protein
- Putative F-box/kelch-repeat protein At1g20940
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Sequence:
MAELIIVDFQNISIFILLCLFSFLCYALFFKKPKGFDLPPSPPSLPIIGHLHHLLSSSLPHKSFQKLSFKYGPLLHLRIFNFPMVLVSSASMAYEVFRTNDVNVSYRFVPVNKDSLVFGSSGFVTAPYGDYWKFMKKLISTKLLRPHALELSKGNRAEELRRFCLDLQGKARKKESVEIGKVALKLTNNIICRMSMGRSCSEKNGVAERARELVNKSFALSVKLFFSNMFRKDIMGVSREFDEFLERILVEHEENLEGDQDRDMIDHLLEAYRNEEAEYKITRKQIKSLIVEIFLGGTDSSAQTIQWTMAEILNNPGVLEKLRAEIDSVVGGKRLIQESDLPNLPYLQAVVKEGLRLHPSAPVLLRVFGESCEVKEFYVPEKTTLVVNLYAVNRDPDSWEDPDMFKPERFLVSSISGDEEKIREQAVKYVTFGGGRRTCPAVKLAHIFMETAIGAMVQCFDWRIKGEKVYMEEAVSGLSLKMAHPLKCTPVVRFDPFSF
Protein: Protein YNG1 (ING1 homolog 1) (Q08465)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Histone-binding component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. YNG1 is required for the HAT activity of NuA3 but not for its integrity. Mediates the interaction of SAS3 with nucleosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Chromatin modification-related protein EAF6
- Histone acetyltransferase SAS3
- NuA3 HAT complex component NTO1
- Transcription initiation factor TFIID subunit 14
- NuA3 HAT complex component PDP3
- Histone H3
- Chromatin modification-related protein EAF3
- Histone acetyltransferase GCN5
- Histone deacetylase RPD3
- Transcriptional regulatory protein RCO1
Sequence:
MEHLANENSDSDIRYSFLSTLDHLPCELIRSLRLMQTIDLFKNEEDEPGMERACRDLLLVATYINDLVDDQIHFLKQHKKELEIQKSVTKNFNSSLENIKSKLTLEEPGAYKEPKLLLKINLKKAKSRERKESITSPTIGINQGDVTEGNNNQEEVYCFCRNVSYGPMVACDNPACPFEWFHYGCVGLKQAPKGKWYCSKDCKEIANQRSKSKRQKRRK
Protein: RCC1 domain containing 1 (G3V2I3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS
Protein: GH04558p (LP02738p) (Piopio protein) (Piopio, isoform B) (Piopio, isoform D) (Piopio, isoform E) (Q8IRK0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Nucleolar GTP-binding protein 1
Sequence:
MKTGTRMDAFHTALHLITIAALTTHAAQIPTAMKDAQSSLSDAIAAAEAEVASTSKPAVEPSVRIKCLSGSMLITIKDAPPNHETGLFSGMIYPKGLSKNSTCLSEYRDHVGSLRYKLPLRSCNTMPKETDDGGIEFFNTIVLQPHLKLITDLGRGYHVRCAYKSRDAAMKPKKYLRKHAQKPQAFRSDDRREYGRSLDKQQDDDLDEEDVYDANAPTQEEDVTNNEIPMPGCHMKIYNDEHKIADDVKIGDPLTIVISIDKQKVYGLHVTDCIVRDGLGWGEQRLVGEDGCPMDNEIMGQFNYTQDRLAANVTFPAHKFPYTTSVYYQCNVRLCALEDPTCQEAPQCSGKRPKRQAAADSKEEDGLPATIEVFSGLYVNENENANDSDEDAVYKEKTLDDALCVSQRTFAIAIAIAGLILMLAVVAAVLCIMARRSTKTVSNSGSSIYSGPYTNTAFSHSS
Protein: 6-aminohexanoate-oligomer endohydrolase (EC 3.5.1.117) (6-aminohexanoate oligomer hydrolase) (Ahx endo-type-oligomer hydrolase) (Nylon hydrolase) (Nylon oligomer-degrading enzyme EIII) (Nylonase) [Cleaved into: 6-aminohexanoate-oligomer endohydrolase alpha subunit; 6-aminohexanoate-oligomer endohydrolase beta subunit] (Q79F77)
Organism: Paenarthrobacter ureafaciens
Function: Involved in the degradation of nylon-6 oligomers. Degrades cyclic and linear oligomers of 6-aminohexanoate (Ahx) with a degree of polymerization greater than three by an endo-type mode. Cannot use Ahx cyclic dimer or the Ahx linear dimer.
Interaction partners:
Sequence:
MNTTPVHALTDIDGGIAVDPAPRLAGPPVFGGPGNDAFDLAPVRSTGREMLRFDFPGVSIGAAHYEEGPTGATVIHIPAGARTAVDARGGAVGLSGGYDFNHAICLAGGAGYGLEAGAGVSDALLERLEHRTGFAELQLVSSAVIYDFSARSTAVYPDKALGRAALEFAVPGEFPQGRAGAGMSASAGKVDWDRTEITGQGAAFRRLGDVRILAVVVPNPVGVIVDRAGTVVRGNYDAQTGVRRHPVFDYQEAFAEQVPPVTEAGNTTISAIVTNVRMSPVELNQFAKQVHSSMHRGIQPFHTDMDGDTLFAVTTDEIDLPTTPGSSRGRLSVNATALGAIASEVMWDAVLEAGK
Protein: Zinc transporter 7 (ZnT-7) (Solute carrier family 30 member 7) (Znt-like transporter 2) (Q8NEW0)
Organism: Homo sapiens (Human)
Function: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:15525635}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JKN1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9JKN1}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q5BJM8}. Mitochondrion {ECO:0000250|UniProtKB:Q5BJM8}.
Interaction partners:
- Alkaline phosphatase, tissue-nonspecific isozyme
- Zinc transporter SLC39A7
- Zinc transporter ZIP9
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP11
- Zinc transporter ZIP1
- Zinc transporter ZIP13
- Metal cation symporter ZIP14
- Zinc transporter ZIP5
- Zinc transporter ZIP6
Sequence:
MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSHDGPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM
Protein: Calcium and integrin-binding protein 1 (Calmyrin) (A0A140VK09)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Cell projection, filopodium tip {ECO:0000256|ARBA:ARBA00004495}. Cell projection, growth cone {ECO:0000256|ARBA:ARBA00004624}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}.
Interaction partners:
Sequence:
MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL
Protein: DNA-directed RNA polymerase II subunit 2 (DNA-directed RNA polymerase II 135 kDa polypeptide) (DNA-directed RNA polymerase II subunit RPB2) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (EC 2.7.7.6) (Protein EMBRYO DEFECTIVE 1989) (P38420)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. NRPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase II subunit 4
- DNA-directed RNA polymerases II, IV and V subunit 3
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases II and V subunit 6B
- DNA-directed RNA polymerases II, IV and V subunit 6A
- DNA-directed RNA polymerases II, IV and V subunit 9A
- DNA-directed RNA polymerases II and V subunit 8A
- DNA-directed RNA polymerases II, IV and V subunit 10
- DNA-directed RNA polymerases II, IV and V subunit 9B
Sequence:
MEYNEYEPEPQYVEDDDDEEITQEDAWAVISAYFEEKGLVRQQLDSFDEFIQNTMQEIVDESADIEIRPESQHNPGHQSDFAETIYKISFGQIYLSKPMMTESDGETATLFPKAARLRNLTYSAPLYVDVTKRVIKKGHDGEEVTETQDFTKVFIGKVPIMLRSSYCTLFQNSEKDLTELGECPYDQGGYFIINGSEKVLIAQEKMSTNHVYVFKKRQPNKYAYVGEVRSMAENQNRPPSTMFVRMLARASAKGGSSGQYIRCTLPYIRTEIPIIIVFRALGFVADKDILEHICYDFADTQMMELLRPSLEEAFVIQNQLVALDYIGKRGATVGVTKEKRIKYARDILQKEMLPHVGIGEHCETKKAYYFGYIIHRLLLCALGRRPEDDRDHYGNKRLDLAGPLLGGLFRMLFRKLTRDVRSYVQKCVDNGKEVNLQFAIKAKTITSGLKYSLATGNWGQANAAGTRAGVSQVLNRLTYASTLSHLRRLNSPIGREGKLAKPRQLHNSQWGMMCPAETPEGQACGLVKNLALMVYITVGSAAYPILEFLEEWGTENFEEISPSVIPQATKIFVNGMWVGVHRDPDMLVKTLRRLRRRVDVNTEVGVVRDIRLKELRIYTDYGRCSRPLFIVDNQKLLIKKRDIYALQQRESAEEDGWHHLVAKGFIEYIDTEEEETTMISMTISDLVQARLRPEEAYTENYTHCEIHPSLILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGIYVTNYQFRMDTLAYVLYYPQKPLVTTRAMEHLHFRQLPAGINAIVAISCYSGYNQEDSVIMNQSSIDRGFFRSLFFRSYRDEEKKMGTLVKEDFGRPDRGSTMGMRHGSYDKLDDDGLAPPGTRVSGEDVIIGKTTPISQDEAQGQSSRYTRRDHSISLRHSETGMVDQVLLTTNADGLRFVKVRVRSVRIPQIGDKFSSRHGQKGTVGMTYTQEDMPWTIEGVTPDIIVNPHAIPSRMTIGQLIECIMGKVAAHMGKEGDATPFTDVTVDNISKALHKCGYQMRGFERMYNGHTGRPLTAMIFLGPTYYQRLKHMVDDKIHSRGRGPVQILTRQPAEGRSRDGGLRFGEMERDCMIAHGAAHFLKERLFDQSDAYRVHVCEVCGLIAIANLKKNSFECRGCKNKTDIVQVYIPYACKLLFQELMSMAIAPRMLTKHLKSAKGRQ
Protein: Serine/threonine-protein kinase RCK1 (EC 2.7.11.1) (P38622)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- AP-1-like transcription factor YAP2
- Mitogen-activated protein kinase HOG1
Sequence:
MSVNPEFIADGIDFYPTTPDAAYFNAADGKNKVNRINGNSENLHHSFASGCRRSSLSVDFNVTSSDSEKSEQSCLENNSQEDEYFCDIFSTELKLDETSNKSTDYSSSNHQYPEQLELHNYKLLNKIGEGAFSRVFKAVGINTDDQAPVAIKAIIKKGISSDAILKGNDRIQGSSRKKVLNEVAIHKLVSKNNPHCTKFIAFQESANYYYLVTELVTGGEIFDRIVQLTCFSEDLARHVITQVAIAIKHMHYMGIVHRDVKPENLLFEPIPFYGLDGDMQKEDEFTLGVGGGGIGLVKLMDFGLAKKLRNNTAKTPCGTIEYVASEVFTSKRYSMKVDMWSIGCVLFTLLCGYPPFYEKNEKTLLKKISRGDYEFLAPWWDNISSGAKNAVTHLLEVDPNKRYDIDDFLNDPWLNSYDCLKDSNSNSYASVQSILNDSFDERAETLHCALSCQSEKQDDTEFSRSESSEYIFMTEEDRNLRGSWIGEPKECFTLDLATSSIYRRRKNKIFFW
Protein: Autophagy-related protein 16 (Q6NNP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in autophagy.
Interaction partners:
- Ubiquitin-like protein ATG12B
- Autophagy-related protein 18b
- Autophagy protein 5
- Autophagy-related protein 3
- Ubiquitin-like protein ATG12A
- Ubiquitin-like modifier-activating enzyme atg7
- Beclin-1-like protein
- Serine/threonine-protein kinase VPS15
- Phosphatidylinositol 3-kinase VPS34
- Autophagy-related protein 11
Sequence:
MVQEEKAMEAINDALRALRKRHLLEEGAHAPAISALSKPLISQGSEWKEKTEKLETELQQCYKAQSRLSEQLVIEVAESRTSKAILQEKELLINDLQKELTQRREDCTRLQEELEEKTKTVDVLIAENLEIRSQLEEMTSRVQKAETENKMLIDRWMLQKMQDAERLNEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVESTIPSTCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGTLIKSLYGSLGNILDMAVTHDNKSVIAATSSNNLFVWDVSSGRVRHTLTGHTDKVCAVDVSKFSSRHVVSAAYDRTIKLWDLHKGYCTNTVLFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNRILTSGRDNVHNVFDTRTLEICGTLRASGNRLASNWSRSCISPDDDYVAAGSADGSVHVWSLSKGNIVSILKEQTSPILCCSWSGIGKPLASADKNGYVCTWT
Protein: ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx) (Q7Z478)
Organism: Homo sapiens (Human)
Function: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03068}.
Interaction partners:
- Eukaryotic translation initiation factor 1
- Eukaryotic initiation factor 4A-II
- Eukaryotic initiation factor 4A-I
- Eukaryotic translation initiation factor 4B
- Eukaryotic translation initiation factor 1A, X-chromosomal
- Eukaryotic translation initiation factor 4 gamma 1
- Eukaryotic translation initiation factor 3 subunit B
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS3
Sequence:
MGGKNKKHKAPAAAVVRAAVSASRAKSAEAGIAGEAQSKKPVSRPATAAAAAAGSREPRVKQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVINEHKKQNNDKGMISGRLTAKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALDWLCLNLSDDALPEGFSQEFEEQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKPKKEEKNMEVNMKEWILRYAEQQNEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKEQAATFKLEKNKQGQKEAQEKIRKFQREMETLEDHPVFNPAMKISHQQNERKKPPVATEGESALNFNLFEKSAAATEEEKDKKKEPHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVPVGRYWKCRVRVIKSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDAEKKREELNKMETNKPRDLFIAKLLNKLKQQQQQQQQHSENKRENSEDPEESWENLVSDEDFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKDSEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYMNPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYNAYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWEGNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSSVNRDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQAPVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN
Protein: Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15 (P96284)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1
- Mycolipanoate synthase
- Probable polyketide synthase Pks17
- p-hydroxybenzoic acid--AMP ligase FadD22
- 4-hydroxyphenylalkanoate adenylyltransferase
- Chorismate pyruvate-lyase
- Phenyloxazoline synthase MbtB
- Peptide synthetase MbtE
- Probable oxidoreductase
- Probable NADPH quinone oxidoreductase FadB4
Sequence:
MIEEQRTMSVEGADQQSEKLFHYLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGRRWCRG
Protein: UBC core domain-containing protein (Q54KR7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ubiquitin-like protein
- SUMO-activating enzyme subunit 1
- Sumo-conjugating enzyme ubc9
- SUMO-activating enzyme subunit 2
- Proliferating cell nuclear antigen
- Ubiquitin-like protein
- HECT-type E3 ubiquitin transferase
- Polyadenylate-binding protein 2
- Potassium channel tetramerisation-type BTB domain-containing protein
- RNA-binding region RNP-1 domain-containing protein
Sequence:
MSLAQTRLTEERKAFRKDHPVGFHARPVTNADDTLNLLKWTCGVPGKVGTPWEGGIYDVTITFKDDYPSRPPVCSFPKGFFHLNCFPSGDICLSILNNEWKPSISIKNILLGIQELLDSPNPDSAANSEAYSLWKKDKAGYLKRIKDQAKLYDAQRLLE
Protein: GTP:AMP phosphotransferase (PfGAK) (EC 2.7.4.10) (Q8I1T1)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the reversible transfer of the terminal phosphate group between GTP and AMP. Has very low activity with UTP, ITP, CTP and IMP and no activity with ATP, GMP, CMP and UMP in vitro.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22819813}.
Interaction partners:
- Adenylate kinase isoenzyme 6 homolog
- Adenylosuccinate lyase
- Ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase
- nucleoside-diphosphate kinase
- Ribonucleoside-diphosphate reductase small chain, putative
- Ribonucleoside-diphosphate reductase small chain, putative
- Pyruvate kinase
- pyruvate kinase
- AMP deaminase
Sequence:
MRIVLFGAPGVGKGTFAEILSKKENLKHINVGNILRNEIKKESNIGKEVQNVVRSGNLVSDSLIINIVHDEMKNILNKKYKGFILDGFPRNMYQSKELIKMTNIDLFVNIYLPRNILIKKLLGRRICNICDKNFNVSNIQQDSFDMPPILPSKDCIQCNGHTNLIKRKDDNEDIINHRLNSYESDYIPIIQFFKNEKYNLIDFPLRRGIRDFDDFYSILVNYRKNEKLK