wanglab/gogpt-training-data huggingface dataset:
Protein: Myb-binding protein 1A (Myb-binding protein of 160 kDa) (Q7TPV4)
Organism: Mus musculus (Mouse)
Function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12941609}. Nucleus, nucleolus {ECO:0000269|PubMed:12941609, ECO:0000269|PubMed:19129230}. Cytoplasm {ECO:0000269|PubMed:12941609}. Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1. {ECO:0000269|PubMed:12941609}.
Interaction partners:
- KRR1 small subunit processome component homolog
- Nucleolar RNA helicase 2
- DNA-directed RNA polymerase I subunit RPA1
- HEAT repeat-containing protein 1
- Pescadillo homolog
- DNA-directed RNA polymerase I subunit RPA2
- Protein RRP5 homolog
- Periodic tryptophan protein 2 homolog
- Tyrosine-protein kinase BAZ1B
- Nucleolar protein 6
Sequence:
MAEMKSPTKAEPATPAEAAQSDRHSLLEHSREFLDFFWDIAKPDQETRLRATEKLLEYLRTRPNDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIPLCDILDQIQEKYSLQAMNKAMMRPSLFANLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQPIKALVDILSEVPESMFQEILPKVLKGNMKVILRSPKYLELFLLAKQRVPTKLESLMGSVDLFSEDNIPSLVNILKVAANSVKKEHKLPNVALDLLRLALKESRFELFWKKVLEEGLLKNPSWTSSYMCFRLLGASLPLLSEEQLQLVMRGDLIRHFGENMVISKPQNLFKIIPEISTYVGTFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQPDLNSLVDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKTKKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADMLLNHNRNVTSVTSLTTQQRQAWDQMMSTLKELEARSSETRAIAFQHLLLLVGLHIFKSPAESCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHICPHLTPRCLQLILAVLSPVTNEDEDDNVVVTDDADEKQLQHGEDEDSDNEDNKNSESDMDSEDGEESEEEDRDKDVDPGFRQQLMEVLKAGNALGGVDNEEEEELGDEAMMALDQNLASLFKEQKMRIQARNEEKNKLQKEKKLRRDFQIRALDLIEVLVTKQPEHPLILELLEPLLNVIQHSMRSKGSTKQEQDLLHKTARIFMHHLCRARRYCHEVGPCAEALHAQVERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRHQDGHKLHGADTEDSEDQAANCLDLDFVTRVYSASLESLLTKRNSSLTVPMFLSLFSRYPVICKNLLPVLAQHVAGPSRPRHQAQACLMLQKTLSARELRVCFEDPEWEQLITQLLGKATQTLQTLGEAQSKGEHQKELSILELLNTLLRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQQGNHSSGSNRLYDLYWQAMRMLGVQRPKSEKKNAKDIPSDTQSPVSTKRKKKGFLPETKKRKKLKSEGTTPEKNAASQQDAVTEGAMPAATGKDQPPSTGKKKRKRVKASTPSQVNGITGAKSPAPSNPTLSPSTPAKTPKLQKKKEKLSQVNGATPVSPIEPESKKHHQEALSTKEVIRKSPHPQSALPKKRARLSLVSRSPSLLQSGVKKRRVASRRVQTP
Protein: LRR receptor-like serine/threonine-protein kinase RGI1 (EC 2.7.11.1) (Protein RECEPTOR OF RGF1 4) (Protein RGF1 INSENSITIVE 1) (Protein ROOT CLAVATA-HOMOLOG1 2) (Q9LHP4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with RGI2, RGI3, RGI4 and RGI5, acts as receptor of RGF peptides (e.g. RGF1, GLV5/CLEL1/RGF2, GLV7/CLEL3/RGF3, GLV3/RGF4, GLV10/CLEL7/RGF5 and RGF10/CLELN), peptide hormones which maintain the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT, e.g. PLT1 and PLT2). Links RGF peptides signal with their downstream components.
Subcellular location: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Tapetum-specific protein A9
- Flowering-promoting factor 1-like protein 2
- Flowering-promoting factor 1-like protein 1
Sequence:
MSLHSLIFFSSSSSSLLFSFFFIFIFCFSLSDAEQNPEASILYSWLHSSSPTPSSLSLFNWNSIDNTPCNNWTFITCSSQGFITDIDIESVPLQLSLPKNLPAFRSLQKLTISGANLTGTLPESLGDCLGLKVLDLSSNGLVGDIPWSLSKLRNLETLILNSNQLTGKIPPDISKCSKLKSLILFDNLLTGSIPTELGKLSGLEVIRIGGNKEISGQIPSEIGDCSNLTVLGLAETSVSGNLPSSLGKLKKLETLSIYTTMISGEIPSDLGNCSELVDLFLYENSLSGSIPREIGQLTKLEQLFLWQNSLVGGIPEEIGNCSNLKMIDLSLNLLSGSIPSSIGRLSFLEEFMISDNKFSGSIPTTISNCSSLVQLQLDKNQISGLIPSELGTLTKLTLFFAWSNQLEGSIPPGLADCTDLQALDLSRNSLTGTIPSGLFMLRNLTKLLLISNSLSGFIPQEIGNCSSLVRLRLGFNRITGEIPSGIGSLKKINFLDFSSNRLHGKVPDEIGSCSELQMIDLSNNSLEGSLPNPVSSLSGLQVLDVSANQFSGKIPASLGRLVSLNKLILSKNLFSGSIPTSLGMCSGLQLLDLGSNELSGEIPSELGDIENLEIALNLSSNRLTGKIPSKIASLNKLSILDLSHNMLEGDLAPLANIENLVSLNISYNSFSGYLPDNKLFRQLSPQDLEGNKKLCSSTQDSCFLTYRKGNGLGDDGDASRTRKLRLTLALLITLTVVLMILGAVAVIRARRNIDNERDSELGETYKWQFTPFQKLNFSVDQIIRCLVEPNVIGKGCSGVVYRADVDNGEVIAVKKLWPAMVNGGHDEKTKNVRDSFSAEVKTLGTIRHKNIVRFLGCCWNRNTRLLMYDYMPNGSLGSLLHERRGSSLDWDLRYRILLGAAQGLAYLHHDCLPPIVHRDIKANNILIGLDFEPYIADFGLAKLVDEGDIGRCSNTVAGSYGYIAPEYGYSMKITEKSDVYSYGVVVLEVLTGKQPIDPTVPEGIHLVDWVRQNRGSLEVLDSTLRSRTEAEADEMMQVLGTALLCVNSSPDERPTMKDVAAMLKEIKQEREEYAKVDLLLKKSPPPTTTMQEECRKNEMMMIPAAAASSSKEMRREERLLKSNNTSFSASSLLYSSSSSIE
Protein: Probable feruloyl esterase B (EC 3.1.1.73) (Ferulic acid esterase B) (FAEB) (Q5BCF8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Feruloyl esterase C
Sequence:
MALLRHLLPVLTVGSAVQSAVLVQDQFQTRCENFAGKIDLPNVKVNFASYIPGSTNLTLDNVPTCDQSQVVSSDICRVAMAVTTSNASEITLEAWFPRDYTGRFLSTGNGGLGGCIQYSDLDYASRLGFATVGANNGHNGTSGEPFYKAPEVLEDFVYRSVHTGIVVGKQLTKLFYDEGFDTSYYLGCSTGGRQGFKLAQDFPGEVDGIIAGAPAINFVGLLSWSAHFYPITGPVGSATYLSLDDWDLVHEEILRQCDGLDGAEDGIIEDPDLCHPNATTLLCSPGATSGSCLTATQVNTVHEVYAPLLSSNSTLIYPRMQPGGEQFAAPAMYNGQPFQYSKDWWRYVVYSDPTWNATKWTIRDAEAALRQNPYNIQTWNADLSPLRDSGSKLLTYHGLQDQLISSDDSKLYYHRLMKTMGVTSNQLDEFYRFFQISGMAHCQDGDGAYGIGNRAETEFSTEPEDNVLMAMVRWVEEGIAPETVRGAKFSDGVGSEVEYYRKHCRYPRRNVYKGPGDYTDETAWECV
Protein: Peroxidase 42 (Atperox P42) (EC 1.11.1.7) (ATP1a/ATP1b) (PRXR1) (Q9SB81)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Interaction partners:
Sequence:
MGGKGVMMVAILCLWALSATSEAVTEAEPGLMMNFYKDTCPQAEDIVREQVKLLYKRHKNTAFSWLRNIFHDCAVESCDASLLLDSTRRELGEKEHDRSFGLRNFRYIEEIKEALERECPGVVSCSDILVLSAREGIEAVGGPYIPLKTGRRDGLKSRTDMLESYLPDHNESISVVLEKFKSIGIDTPGLVALLGSHSVGRTHCVKLVHRLYPEVDPSLNPDHVPHMLHKCPDSIPDPKAVQYVRNDRGTPMVLDNNYYRNILDNKGLLLVDHQLAHDKRTRPIVKKMAKDQAYFFKEFTRAIQILSENNPLTGSKGEIRKQCNLANKNH
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair cross-complementing protein-3 homolog) (DNA repair helicase repB) (DNA repair protein B) (O00835)
Organism: Dictyostelium discoideum (Social amoeba)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/repB, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/repB is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription factor IIH subunit 1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 4
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIH subunit 2
- General transcription factor IIE subunit 1
- General transcription factor IIE subunit 2
- Putative cyclin-H
- Transcription initiation factor IIB
Sequence:
MSSGDSNLKRRRGGNTGQSSKSYNTWTDYEEDLEESGEFNQSIKKTTNTSSATLTSSEEKGSLLDYSKRCILKQDNKSRPIWVCPDGHIFLETFSAIYKQASDFLVAIAEPVCRPQNIHEYQLTPYSLYAAVSVGLETNDIITVLGRLSKLALPKEVEQFVRQCTQSYGKVKLVLQKNKYFVESAYPEVLEFLLKDSSIATARIKPTLEESVVDPKTGFIINKEVVTGAQISGGLQANQSLDPVLKNDALSNLLEEEEEDTVNNSDQHFHSFEIDPQQVEEVKKRCIQLDYPVLEEYDFRNDTVNPNLNIDLKPTTMIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKSLSGITAACTVKKSILVLCTSAVSVEQWKYQFKLWSNIEERQISKFTSDNKEKISNVAGVTITTYTMVAFGGRRSAESLKIMNEITNREWGLVLLDEVHVVPAAMFRKVLTVTKAHCKLGLTATLLREDEKIQDLNFLIGPKLYEANWLDLQKAGFLANVSCSEVWCPMTAEFYKEYLINDSQGKKKLLYTMNPNKFRACEYLIRFHEQRGDKIIVFSDNVYALQKYAKGLGRYFIYGPTSGHERMSILSKFQHDPTVRTIFISKVGDTSIDIPEATVIIQVSSHYGSRRQEAQRLGRILRPKPKSDGLYNAFFYSLVSKDTQEMYYSTKRQQFLIDQGYSFKVISELPGIDQEVNLKYSSKQDQLDLLAQVLGEGEDSGKNEILEEDFDDITRGAKKSKSSAPTVSRTTGGSTRALSGGNDMNYMEYQAPAIYKSIPTQHALFKQRAKNKQ
Protein: Lectin 80 kDa subunit (LsL) (P84821)
Organism: Penaeus setiferus (Atlantic white shrimp) (Litopenaeus setiferus)
Function: Sialic acid-specific lectin. Has hemagglutinating activity towards erythrocytes from several species, with high activity towards, rabbit, mouse and guinea pig erythrocytes, and low activity towards human erythrocytes. Hemagglutinating activity is blocked by treatment of erythrocytes with V.cholerae sialidase.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:15919156}.
Interaction partners:
Sequence:
DASNAQKQHDVNFLL
Protein: Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog) (P56716)
Organism: Mus musculus (Mouse)
Function: Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, photoreceptor outer segment. Note=Specifically localized in the connecting cilia of rod and cone photoreceptors.
Interaction partners:
- Phosducin
Sequence:
MSDTPSTSFSMIHLTSEGQVPSPRHSNITHPVVAKRISFYKSGDPQFGGVRVVVNPRSFKTFDALLDSLSRKVPLPFGVRNISTPRGRHSITRLEELEDGKSYVCSHNKKVLPVDLDKARRRPRPWLSSRSISTHVQLCPATANMSTMAPGMLRAPRRLVVFRNGDPKNKHVVLLSRRITQSFEAFLQYLTQVMQCPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPAKLPGISHRVHQKGKAKIEKRKMSTHMPSDLRPQTDSLISEKTYDCFSDFSVAPENYLALETHESQSLSTYPSEDDVEKSIVFNQDGTMTVVMKVRFKIKEEETVKWTTTVNRAGLSNNDEKNKKSSYPGKTDYGPSSLKLEACSLPEDIVDTTQQGSLTEEENTQMTEQQALSCSSASWENASMETDIQESQKQVKHFYRPPTPGPRRMRQKKSVIGTVTVVSETEVQEKQFSYSEERKGGEKSEYHMFTHSCSKMSSVSNKLVQIGSDNEMESALERTRESGSLKSQAINAGAIEITSQKVLKMCHNNALPSTAPENSVVEEGTDNSAVSGTATIKHFRTCGNANDSFSSITADSTPTSVNNYSNDRNISELPSVGSPVLTMRLVNEFAHCGLTEKPENRKKVLSSSASKKKKKKSQQRMITSNDKKKVIETKGPPNIAGKIPRAGTTAQERLLQESDCPDKGGRVCEQGLNISPMAIESNNFFPKSNPTFSKNFYKNKLNTFQNPKTQKLLAKRKSRPRKIVSTERLRKQEIGQEDKILLHSDSKLCESHLEKQSLFHVFNILEEDQKVLHRPPFQVEKVARNLKGMAKKSLVPKVNDLHIMLRNQKKQMGVKLKSGAEVSEQHVTTRADPLASLKKPDFPEGIPHHSGKSYVKRWLQNINSYPDFEHRKSGPLCQNRSDVVNYNRNGFLGNNLHTTSSKGNGFLMESNKSKTKNDNWSGNTNQETGKSLVAKDNGEELNKHHCESQNGSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPEVKLVYQEMNFATKRQSIEVAIQVDTMGENVLKDYLPALLLRHLEAFVPNNQKHQNGISQIPGSLAEVVFPSVIDNSSTNLLLAWLLVLNLKRTMNSFCQSDAHKMTNRPSETAALLEVLKHVAITEEADDLKAAVANLMESTKTCSGSSGREQDMLPVNCTASSLHSVDECNENGSAQKTLLDEGYSVMGDCTSEMVSKSCNSSCEMHMVSKTNPPKQVDDQSDGLLTSNSCTVSQRSTGACFLTDGVYSHEACAQKEGVYEGACLSDETHIPIRDCHTIHSVHSKENKCTDDLESTEELKTVDKVPKGLSILADSMYKNDSNVSTFQNVNKLSSQRTLLSKTYLDSDKDYSPLEEFQNCPRKKIVNKKKSISSDKEESRTSEEPRSITNSMTSSERNAISELESFEELESQDTSIFNMNVRAEKKSTKETMQKQSEARMSSELINVSGRKIIEQERRNTAILETTARGQVTPPSLAFCYDSNKNTEKEISEGETKMRVKKMVDSMENESYSESSLNFKKHHRSPGTLDWSDYGSDSESGYPCKASSNSHNDDSGQEKEPTRGIVKRAIEKLYGKAEIIKPPFFHGSIHKSQVCPYNSVEVQCAKKTNFYESECQSLVSSEQVSRSSLIFQEFPQVDANGMGDSFGDSSIENVTKSSAHDRVFTEKENGKLIDNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTLIDKNSIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFPDAQNKTCPKEKIPNHHTEEKGNYPSERLCTSVTQAFVSAGNKVHPVCSDAIKTQPLPGSNITHGALQEGDSLDKLYALCGQHCPILTVIIQPVNEESRGFAYRKDSDIENSLDFQLWMKIYPFMPQSKKHVFRSDGRNVSVGEEFAGNVIGDLCDQLYFKSMIDLVDQRANSLGKEINLKKFQLYLKKSFSDPLSTSLLVVENRNSVSLSPSSWTDNFKSIDENNNFLNRLPNSSKNPNQVVRENTNFQFHLELFGQVYLLDICQVEKPLNIKTRSKLEMYYILEGEVLFIWEEEK
Protein: Coiled-coil domain-containing protein 38 (Q502W7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8CDN8}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8CDN8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CDN8}. Note=Localizes to the sperm flagellum, manchette and the perinuclear region of the sperm head. {ECO:0000250|UniProtKB:Q8CDN8}.
Interaction partners:
- Coiled-coil domain-containing protein 42
Sequence:
MSSNLLPTLNSGGKVKDGSTKEDRPYKIFFRDLFLVKENEMAAKETEKFMNRNMKVYQKTTFSSRMKSHSYLSQLAFYPKRSGRSFEKFGPGPAPIPRLIEGSDTKRTVHEFINDQRDRFLLEYALSTKRNTIKKFEKDIAMRERQLKKAEKKLQDDALAFEEFLRENDQRSVDALKMAAQETINKLQMTAELKKASMEVQAVKSEIAKTEFLLREYMKYGFFLLQMSPKHWQIQQALKRAQASKSKANIILPKILAKLSLHSSNKEGILEESGRTAVLSEDASQGRDSQGKPSRSLTRTPEKKKSNLAESFGSEDSLEFLLDDEMDVDLEPALYFKEPEELLQVLRELEEQNLTLFQYSQDVDENLEEVNKREKVIQDKTNSNIEFLLEQEKMLKANCVREEEKAAELQLKSKLFSFGEFNSDAQEILIDSLSKKITQVYKVCIGDAEDDGLNPIQKLVKVESRLVELCDLIESIPKENVEAIERMKQKEWRQKFRDEKMKEKQRHQQERLKAALEKAVAQPKKKLGRRLVFHSKPPSGNKQQLPLVNETKTKSQEEEYFFT
Protein: UBA domain-containing protein 6 (Q10187)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative ubiquitin thioesterase otu1
- Putative G3BP-like protein
- Probable ubiquitin carboxyl-terminal hydrolase 2
- Ubp4-interactor sfp47
Sequence:
MEDLDTKIKTLKNMGVSESDAKDSLERCGYDVESAAEFIFSGQLEKSRLVPIMSSTSIASSLPSYQDTFFLPSPRKRRRLPGRIGTVLKPSALFPAIAPFLFVVFEIPVALNTFVHATCKGLLFAEDNASFHRPFTDVSAHLSSSSLSKYNHHSNHRLASPGWWYGEDSCISQSLDPRSVMQVQTIRAFEFLFSSHRLYLDTVHITAALSQVLAGLGNTNTSMSDGDCIAAFLSSYFSPPNAEFDSTFCSTLSSLTNSEKPTYIFNFKPNSTPDLRLSIESCLDLLLHPPSSAQKNWSWIKHVGKVFCCSLPGNNASGTPRFLLTPKIDLSKCIIENRDEMLRRYQLETVYRKTLLEWEDLYKRLTGVTLTDKDIGELLTDGQQFLEKRNPALSSHLQLLKETLQTKISTLISNTNATQHKLSTLYRGMQNKCTRRLLAVIIEPSIIYICLKNSAVQSNRNVSPSANHNEQWYLVRFTTSATISQDSPPCIVEPVTFEEVDLEFEKHISYHNRLLIYVDDDCEASTRTVIPTSVKNFIAEDNEYFDDELAGIIHSPTVSTRSSRSSDVSEYDLEDQGGLQLTVPHINTDVQCHRSRNSACEFPESMHVEHSG
Protein: Metalloprotease mig-17 (EC 3.4.24.-) (Abnormal cell migration protein 17) (Q20930)
Organism: Caenorhabditis elegans
Function: Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does not recruit fbl-1 to the pharynx basement membrane.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:10864868, ECO:0000269|PubMed:17491590, ECO:0000269|PubMed:18637819, ECO:0000269|PubMed:24318535, ECO:0000269|PubMed:26994289}. Note=Secreted as a zymogen (PubMed:17491590, PubMed:18637819). The zymogen localizes to the basement membrane of gonads, intestine and hypodermis (PubMed:17491590, PubMed:18637819). The mature and active form displays a similar localization but only during the L3 larval stage (PubMed:18637819). {ECO:0000269|PubMed:17491590, ECO:0000269|PubMed:18637819}.
Interaction partners:
- Fibulin-1
- Abnormal cell migration protein 18
- Papilin
- Putative metalloproteinase inhibitor tag-225
- Collagen alpha-2
- Nidogen
Sequence:
MHTFCILIPTFLVLVWTTESARREKQQSNDISFVKRKVQDGLKFSRVIKYTNETIQGMKTNFNSNKTQELSLDVLVVADFLSYQAFLEMSNGDSHRAIHNLKEYLHALFEQTKIIYDGISFGNETLHMVFAGTWIATQERDCPLWISWAEEEEERVLNEEIRRLEEKERDLNSTFVDDTFFMNSTDSDNSSTDALISSDMPKKLRKFVDITLEEMQENNSTEMTLKIDSKKAIDKFTIWLKEQTGLPRHEHAVLITKFDLISINGNSATQGMAYVGNICENGDSSSVVEDIGAGLTSLIMAHEIGHSLGALHDGAYETAECDSNDNYLMAVAVSGSADRQSFLNSRRMSNCSINSIIENLKEPTANCVKKWKTKKGKDVSQKDFIKKPGELVKITRQCQVAFGPTFIPCLHIGYFHEQSICERIWCSDGESDECQTLNYFPAFDGTECGYNMWCLEGSCVQNTKKWMDCKDINSKTCSKYSTSKLKHYCKSKDFREICCRTCAKKGKIY
Protein: Leucine repeat adapter protein 25 (C184L ORF2 protein) (C184M protein) (MMTV receptor) (Q9QUI1)
Organism: Mus musculus (Mouse)
Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12646588}. Cell projection, lamellipodium {ECO:0000269|PubMed:25107909}. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000269|PubMed:25107909}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell surface {ECO:0000269|PubMed:9525630}.
Interaction partners:
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 5
- Cell division cycle protein 16 homolog
- Anaphase-promoting complex subunit 1
- Cell division cycle protein 27 homolog
- Cell division cycle protein 23 homolog
- Ubiquitin-conjugating enzyme E2 C
Sequence:
MNGLPATEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERVYSQRSRIHDELSRAARAPDGPRHAAGSANSGSAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLSSSLHSDSSYPPDAGLSDDEEPPDASLPPDPPPLTVPQTHNARDQWLQDAFQISL
Protein: Uncharacterized protein C1F12.10c (Q10352)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- NADH-cytochrome b5 reductase 1
Sequence:
MVALFKSSLGRPEQHQTPQIRISPASSNVEHSEKQPRRDFRVKKYVAPGFSQLNWSKLVASGQNLSGVEKPIPVTKEELAKHKTKEDCWIAIRGKVYNVSAYLPYHPAGQKRILDYAGRDATVIFMKFHAWVNEEALLKTSFVGFLV
Protein: U3 small nucleolar RNA-associated protein 5 (U3 snoRNA-associated protein 5) (U3 protein 5 required for transcription) (Q9HE11)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 17
- U3 small nucleolar RNA-associated protein 4
- U3 small nucleolar RNA-associated protein 15
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 21 homolog
- Probable U3 small nucleolar RNA-associated protein 7
- Probable U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 6
- U3 small nucleolar ribonucleoprotein protein mpp10
- Periodic tryptophan protein 2 homolog
Sequence:
MAVRSRPQLAFQTEKENGIGITAFNETAKLYANVVEALDAQRLRIFDSVAGSLKTEYILEKEKVISCIAWEQKPLYASEQITTDISGSGEILVLGTNSGEILIYSEHLGSLTRTYSFGILQKIIGAHVLANDGFAIDITGKVVCFSVNTGEVRTSFTVPSSSREFSGLYLSTVFKNLALASSHNIHIVDLNHRNPIDSLTTHTSMINSVVFQYLKDENKFYFGVSANQDRFINLYSKELDGTGEFPTNTVKNVGALVCENEVKMLSIAYEIENPETGVLAALTNDGTIEMFENPWLSKLRQNGTNASSLSHRRKLLTSHSTLKICFCRSRGDPPIVLESIAFESTDSLTVVWKESTRTVFETVPWRILSSQATNGLIELVRSKTRLTSKNKTVSNVYDESNATISSGVMQKDLRKTEEIGSAEAMEGEEQEPSLAERLQNLTKLDQQAQALSTQISASTSLSTVLTQALKTNDQSLLESCFNNNNVETIDTTIRRLDPSLAPILLDKLAEKLALRPMRADVLMVWIRCTLITHGGHLVLVDDLKHKLANLHSILEDRASKYSSMLALQGKLDLVLSQIAFRKAGGSKDNAEDEEPISIYYEGYEESMDEASSTGDEGYSSDDSVDNEMYSDEENSSKGAFPDEENENRELSEDYSGDESLENSESE
Protein: Transcription factor TCP23 (Q9LQF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Suppressor of RPS4-RLD 1
- Transcription factor TCP10
- Transcription factor TCP4
- Transcription factor TCP13
- Transcription factor TCP3
- AT5g49440/K7J8_12
- Transcription factor TCP2
- Transcription factor TCP5
- C2H2-like zinc finger protein
- Putative pentatricopeptide repeat-containing protein At3g15130
Sequence:
MESHNNNQSNNNTTGSAHLVPSMGPISGSVSLTTTAPNSTTTTVTAAKTPAKRPSKDRHIKVDGRGRRIRMPAICAARVFQLTRELQHKSDGETIEWLLQQAEPAIIAATGTGTIPANISTLNISLRSSGSTLSAPLSKSFHMGRAAQNAAVFGFQQQLYHPHHITTDSSSSSLPKTFREEDLFKDPNFLDQEPGSRSPKPGSEAPDQDPGSTRSRTQNMIPPMWALAPTPASTNGGSAFWMLPVGGGGGPANVQDPSQHMWAFNPGHYPGRIGSVQLGSMLVGGQQLGLGVAENNNLGLFSGGGGDGGRVGLGMSLEQKPQHQVSDHATRDQNPTIDGSP
Protein: Transcription factor bHLH76 (Basic helix-loop-helix protein 76) (AtbHLH76) (bHLH 76) (Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 5) (Transcription factor EN 83) (bHLH transcription factor bHLH076) (Q9C670)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Cryptochrome-2
- Adagio protein 2
- Transcription factor IBH1
- Adagio protein 1
- F-box/kelch-repeat protein SKIP30
Sequence:
MSDKDEFAAKKKDLVNTPVDLYPPENPMLGPSPMMDSFRETLWHDGGFNVHTDADTSFRGNNNIDIPLEMGWNMAQFPADSGFIERAAKFSFFGCGEMMMNQQQSSLGVPDSTGLFLQDTQIPSGSKLDNGPLTDASKLVKERSINNVSEDSQSSGGNGHDDAKCGQTSSKGFSSKKRKRIGKDCEEEEDKKQKDEQSPTSNANKTNSEKQPSDSLKDGYIHMRARRGQATNSHSLAERVRREKISERMKFLQDLVPGCDKVTGKAVMLDEIINYVQSLQCQIEFLSMKLSAVNPVLDFNLESLLAKDALQSSAPTFPHNMSMLYPPVSYLSQTGFMQPNISSMSLLSGGLKRQETHGYESDHHNLVHMNHETGTAPDHEDTTADMKVEP
Protein: RE60063p (Q9W5H8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Probable cytosolic Fe-S cluster assembly factor CG17683
- FI01544p
- Ribonuclease kappa
- Uncharacterized protein, isoform C
- Lethal
- Integrator complex subunit 3
- GH11193p
- RabX6, isoform B
- CG2885
Sequence:
MIKNEQRPLNFEKCPESDDELKKRLEIEKLINKNIDKNISFDVLVKLSLAPYGLVNDDFRRILWPQLAGVDINHLGQAPTLDKFQCHPEYNQVVLDVNRSLKRFPPGIPYEQRIALQDQLTVLILRVIQKYPNLRYYQGYHDVAVTFLLVVGEEIAFAIMEQLSTTHFSECMQETMEATQRRLMFIWPIIKFENPELYQFLQNSTVGTLFSLPWYLTWFGHSLTSYRTVVRLYDYFLASPIYTSIFVTAAILLYRSDEILKEDCDMASVHCLLSVIPEDLPFEDLLKTSSSLLNKYSLTLIEKDVEELICQERRKRKTDEALIVKRRQPATSNRIPIITKWLPNILTAKPVILTTAISIVVGVCAYYYNNQYLAAGIS
Protein: Uncharacterized protein (Q38BN6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVSIPFPLQRAGIVSCAEAEGNGDNHCRANPVVIEPHNEDGPNVTSGAEALVAHSVVHNPLVRTVVERIFEDVEENQRPALRHCFRLIPCELTCCPILPEMRLGLEKLRIEHFPASSASDQQLHKVGFSFSVKNNTNVDSKKAYLQAALQTTFPANRFVVIPSGRVKSCGGGVEAMFCVVVVHSTCVMGVQRRFSDRGEFNIHALGVKHLELSTSV