wanglab/gogpt-training-data huggingface dataset:
Protein: Candida glabrata strain CBS138 chromosome L complete sequence (Q6FLU6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome G complete sequence
- Protein transport protein SEC9
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome F complete sequence
- Protein transport protein SEC22
- Candida glabrata strain CBS138 chromosome C complete sequence
- Synaptobrevin homolog YKT6
- Candida glabrata strain CBS138 chromosome K complete sequence
Sequence:
MSQEYQAILSDVQNIQTQLRIYDQLLQNISNLHNVIYSQIDENSEVNKGKLDNLAAEIAKLQQGVANKIKQLSTKIKFHDNEHYVHYSAIRDQFLSLIRKQRLIEYNWKLSCRNEVKRQIDLMSLDLSDAQIDDYLADPENEIYQSIFKRYLLSNEDAKMALNEVEHRMKEIKNLEKRMNDLAILFKEMEELVVQQEEPIDKIDTNVEKVVVDLESGITHTEQAIHIAEQKRKNKKLLISIIFYVCAILLLSIFVAVIVTVSLH
Protein: Protein odd-skipped-related 2 (Q91ZD1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein MSX-1
- Paired box protein Pax-9
Sequence:
MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPAAVDHLQGLYGLSAVQTMHMNHWTLGYPSVHEITRSTITEMAAAQGLVDARFPFPSLPFATHLFHPKQGAIAHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLNPDRKPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF
Protein: Mid2 domain-containing protein (H2KYI0)
Organism: Caenorhabditis elegans
Interaction partners:
- Potassium channel domain-containing protein
- RNA-binding protein sym-2
- RRM domain-containing protein
Sequence:
MQNLTEVLNATLLSNLSDLVSSTSTVSTSTTTTTTTEIPLTTSFPPSDHTTATSIAFISLVVFGVACALIAKIVISHKKKRAELIGSARWRISASRQSASSASSGGMGQNSSATYLPMGRGGNNRSLNNQRQPLNSLDHPTADRLDWERQFFDDSEATTPSRLIFR
Protein: ATP binding cassette subfamily C member 4 (F1LR52)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLPVHTEVKPNPLQDANLCSRLFFWYWDKEVLRAKKDARKPSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDELPERKAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECRKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDIAFSSPAVMSTSNGQPSALTIFETAL
Protein: Protein virB10 (P17800)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Function: VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNDDNQQSAHDVDASGSLVSDTHHRRLSGAQKLIVGGVVLALSLSLIWLGGREKKENGDAPPSTMIATNTKPFHPAPIDVTLDPPAAQEAVQPTAPPPARSEPERHEPRPEETPIFAYTSGDQGTSKRVQQGETDRRREGNGEDSPLPKVEVSAENDLSIRMKPTELQPTRATLLPHPDFMVTEGTIIPCILQTAIDTSLAGYVKCVLPWDVRGTTNNVVLLDRGTTVVGEIQRGLQQGDARVFVLWDRAETPDHAMISLASPSADELGRSGLPGTVDNHFWQRFSGAMLLSVVQGAFQAASTYAGSSGGGTSFNSVQNNGEQTADTALKATINIPPTLKKNQGDTVSIFVARDLDFSGIYQLRMAGRAARGRDRRP
Protein: Engulfment and cell motility protein 1 (Protein ced-12 homolog) (Q8BPU7)
Organism: Mus musculus (Mouse)
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK. {ECO:0000250}.
Interaction partners:
- Dedicator of cytokinesis protein 1
- Dedicator of cytokinesis protein 2
- Rho-related GTP-binding protein RhoG
- Adapter molecule crk
- Ras-related C3 botulinum toxin substrate 2
- Engulfment and cell motility protein 3
- Engulfment and cell motility protein 2
- Breast cancer anti-estrogen resistance protein 1
- Tyrosine-protein kinase HCK
- Ras-related C3 botulinum toxin substrate 3
Sequence:
MPPPSDIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGTDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRYIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN
Protein: Vomeronasal 2, receptor 74 (A0A3B2WBJ5)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MFFLNSVFWLLKISFNFGHLSDPRCFWRIKDTENKLGDKETYCFFTISTKHGYVKNDYFRWNLDKKVTPKTRHLIFSVYLALEEINKNCHILPNISLVVNIECVLDKHDEKTDFLFKSEDLIPNYYCKNERRYLIVLTAPLWAVSSSIGPYLFMSRIPELYCGHFHLPLSDNEQYPHLHQISRKDTFLPLAMVSLVVHFRWNWIGVIVTNDDHGIQFLSEFRGEMQNKIVCLSFAIIIKTGKFLAVTELHMNYKQILMSSAKVVIVYGYRDSPIIYAFIVWKSQDLFRIWVSVSQLDMITFLGDFLLYASTGTFIFSHQKPEISGFEQFIQRIHPSNYSSEFSLAKQWWTYFRCSLPPSNCKKLKNCSTKTVFKWLFMTPLGLAMSDTCYNIYNAMYAVAHSLHGMLLQQVDTWSKNAGKELEFDSWKMFSILKTLKFVNPAGDLVNMNQNLKQDVEFDVFYIMDFQKDYGLKMKIGRFSEHLPSGQQIYMSKEMIEWATDIDQILPSICTMPCRPGLRKSPQEGKDICCFDCKPCSENEVSNMTNMDQCVKCPEDQYANEDHTVCLQKVVTILDYRDPLGKALAGFALCFSVLTSLVLVVFLKHRDTPIVKANNQTLSFVLLISLIFCFICSLLYIGHPTMAICILQQTTFAIVFTVATSTILSKTVIVILAFKITVPGRRMRWLLESGTPKYIIPICTIIQLILCGIWLGTSPPFVDADLHMVHGHILIVCNKGSVIAFYCVLGYMGSVALASFTVAFLARNLPDTFNEAKLLTFSMLVFCSVWITFIPVYHSTKGKTMVAVEVFCILASSAGLLLCIFAPKCYIILLRPQKNYFYKFRKRRELNLTT
Protein: Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] (Q92838)
Organism: Homo sapiens (Human)
Function: Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O54693}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54693}.; SUBCELLULAR LOCATION: [Ectodysplasin-A, secreted form]: Secreted {ECO:0000269|PubMed:11309369, ECO:0000269|PubMed:34582123}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member EDAR
- Tumor necrosis factor receptor superfamily member 27
- Ectodysplasin-A receptor-associated adapter protein
- Protein Wnt-10a
- Paired box protein Pax-9
- Phospholamban
Sequence:
MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCCYLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAALHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS
Protein: NAD-dependent deacetylase sir2D (EC 2.3.1.286) (Silent information regulator sir2D) (Q54GV7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression.
Interaction partners:
- NAD-dependent deacetylase sir2A
- Glutamine-dependent NAD
- Nicotinamide-nucleotide adenylyltransferase
- NAD+ kinase family protein
- NAD+ kinase family protein
- NAD
- DNA 3'-5' helicase
Sequence:
MNKRSLENNELNEIQNNQNKNNNNKINKEIPSDNTPLKKLKSINSLEQLQEVDEDEDLDVEIDTKLINKLDKKGRKYEFVGEGYSDEEQISDDYEDDESSEYEYGYENEDELLDDEDHLDNINEIKKIQKKLVNTETSTSITNTSSTTTTSTSTTTTTTTKTQINETILLDILNNNKDEVDDEIQRIGNNVGNSKEEEGEEEEENIELVARSFIYKHIQEKKSLGIDPIEFTKDIGFKLELEKDDDAWEIITAFLTRKKVAVNLFLNYLKYNTLARPYRKKIATLDLSTFEKVCQLFESSKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLPRPESLFDIHYLRANPLPFFEFAKEIFPGNHKPSPTHSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSFSTATCITCKLTVDGTTIRDTIMKMEIPLCQQCNDGQSFMKPDIVFFGENLPDRFDQCVLKDVKDIDLLIVMGSSLQVQPVSLLPDIVDKQIPQILINRELVAQPHEFDYVYLGDCDQFVQDLLNKVKW
Protein: Importin subunit alpha-2 (Karyopherin subunit alpha-2) (P91276)
Organism: Caenorhabditis elegans
Function: Nuclear transport receptor that mediates nuclear import of proteins, and which is involved in sister chromatid cohesion. Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signals (NLS) motif (By similarity). Promotes docking of import substrates to the nuclear envelope (By similarity). Together with akir-1 adapter, required for the import and load of cohesin complex proteins in meiotic nuclei.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11311162, ECO:0000269|PubMed:12221121}. Nucleus {ECO:0000269|PubMed:11311162, ECO:0000269|PubMed:12221121, ECO:0000269|PubMed:30563860}. Nucleus envelope {ECO:0000269|PubMed:12221121}. Note=In interphase germ cells and embryonic cells, localizes to the cytoplasm and nuclear envelope, whereas in developing oocytes, it localizes in the cytoplasm and nucleus. {ECO:0000269|PubMed:12221121}.
Interaction partners:
- Importin N-terminal domain-containing protein
- Nuclear Pore complex Protein
- Regulator of chromosome condensation
- Exportin-2
- Akirin
- GTP-binding nuclear protein ran-1
- Nuclear cap-binding protein subunit 2
- Importin N-terminal domain-containing protein
- Nuclear cap-binding protein subunit 1
- Sentrin-specific protease
Sequence:
MTLTETSLSHNAEEGKDEGGRLQQYKNLTKHEELRRRRTECSVEIRKQKGADMMMKRRNIVDVDEGGNSESELEEPEKISHQQSSTRLSNDEIRAILSNNPSEDDMVRCFESLRKSLSKTKNPPIDEVIHCGLLQALVQALSVENERVQYEAAWALTNIVSGSTEQTIAAVEAGVTIPLIHLSVHQSAQISEQALWAVANIAGDSSQLRDYVIKCHGVEALMHLMEKVDQLGDSHVRTIAWAFSNMCRHKNPHAPLEVLRVLSKGLVKLVQHTDRQVRQDACWAVSYLTDGPDEQIELARESGVLPHVVAFFKEAENLVAPALRTLGNVATGNDSLTQAVIDLGSLDEILPLMEKTRSSSIVKECCWLVSNIIAGTQKQIQAVLDANLLPVLINVLKSGDHKCQFEASWALSNLAQGGTNRQVVAMLEDNVVPALCQALLQTNTDMLNNTLETLYTLMLTVQNGYPHKVDILHDQVEENGGLDSLERLQESQSEQIYTQAYRIITQFFTDDDAGEKESHENADPQDNKWSF
Protein: Inner kinetochore subunit sim4 (CENP-K homolog) (Constitutive centromere-associated network protein sim4) (Silencing in the middle of the centromere protein 4) (O94494)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular location: Nucleus. Chromosome, centromere. Note=Associates with the central core region of the centromere.
Interaction partners:
- Inner kinetochore subunit mis6
- Inner kinetochore subunit mis17
- Inner kinetochore subunit mal2
- Inner kinetochore subunit fta2
- Inner kinetochore subunit fta6
- Inner kinetochore subunit fta7
- Inner kinetochore subunit mis15
- Inner kinetochore subunit fta3
- Inner kinetochore subunit fta1
- Inner kinetochore subunit fta4
Sequence:
MNSENASLFRNILNDTENLVQPLTQDESRLALFESLVQSDQLLVEKIEKWEKKVSKFTENSKSEKRKLQLELFQEIIDLKKCIAFKPIIGKNAIDNNISDLKKNLHSNKKLEAVLKEELHQIKKFSSDLQSLKSSMGERQKQQAAMSRRGKKSIIHSAIIQEKERYEKESQELFTFLDGFLDEHAPSLLEGAQASIDKNRPGKNQPSLNFENISKKDLTEEFKQVIENLMNNSIIPGSPYIEVKNERIVSFLVLASLCTVDPQDPSKVKLIPFSDEI
Protein: Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4) (Q9BXJ3)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:21658842}.
Interaction partners:
Sequence:
MLPLLLGLLGPAACWALGPTPGPGSSELRSAFSAARTTPLEGTSEMAVTFDKVYVNIGGDFDVATGQFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQALAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGATFSGYLVYADADADAPARGPPAPPEPRSAFSAARTRSLVGSDAGPGPRHQPLAFDTEFVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLALRRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLAPAAPPGLGASELL
Protein: Platelet-derived growth factor D (PDGF-D) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)] (Q925I7)
Organism: Mus musculus (Mouse)
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Subcellular location: Secreted {ECO:0000250}. Note=Released by platelets upon wounding. {ECO:0000250}.
Interaction partners:
- Platelet-derived growth factor receptor beta
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- Platelet-derived growth factor C
- Pro-epidermal growth factor
- Insulin-like growth factor 1
- Epidermal growth factor receptor
- Insulin-2
- Insulin-1
Sequence:
MQRLVLVSILLCANFSCYPDTFATPQRASIKALRNANLRRDESNHLTDLYQREENIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHQFGLEEAENDICRYDFVEVEEVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFKSDDYFVAKPGFKIYYSFVEDFQPEAASETNWESVTSSFSGVSYHSPSITDPTLTADALDKTVAEFDTVEDLLKHFNPVSWQDDLENLYLDTPHYRGRSYHDRKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTVNWKSCTCSSGKTVKKYHEVLKFEPGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR
Protein: Gremlin-1 (R0KDQ4)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVRTLYAVAAVFLLMGFLVPTAEGRKRNRGSQGAIPPPDKEQPNDSEQIQTQQQSGSRHRERGKGTSMPAEEVLESSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVRKEEGSFQSCSFCKPKKFTTMTVTLNCPELQPPRKKKRITRVKECRCISIDLD
Protein: Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha) (Q9Y5Y3)
Organism: Homo sapiens (Human)
Function: Orphan receptor. May play a role in brain function.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV
Protein: Growth/differentiation factor 8 (GDF-8) (Myostatin) (O08689)
Organism: Mus musculus (Mouse)
Function: Acts specifically as a negative regulator of skeletal muscle growth.
Subcellular location: Secreted {ECO:0000269|PubMed:14671324}.
Interaction partners:
- Activin receptor type-2B
- Activin receptor type-1B
- Activin receptor type-2A
- TGF-beta receptor type-1
- Follistatin
- Follistatin-related protein 3
- WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
- Mothers against decapentaplegic homolog 2
- Latent-transforming growth factor beta-binding protein 3
- F-box only protein 32
Sequence:
MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Protein: DNA repair protein RecO (Recombination protein O) (Q9RW50)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Interaction partners:
- Recombination protein RecR
- DNA replication and repair protein RecF
- Protein RecA
- DNA repair protein RecN
- PhoH-like protein
Sequence:
MRSRTANRSGIVIRRRVTPAGDIIVTLLTPQGKLKAIARGGVKGPLSSSLNLFHHVGVQVYQGPHNDLASVKQAVLEGALPTLAEPERYAFAHLMAEFADALFQEGEFSEQAFDLFAASLRGVAHQPDPEWVALVMSYKLLGLAGVIPQTARCARCGAPDPEHPDPLGGQLLCSKCAALPPYPPAVLDFLRHAVRRTVRASFEQPVPSADRPALWRALEKFVTVQVGGVHSWRQLVPSGVPVLS
Protein: LD04007p (Sp1-like factor for pairing sensitive-silencing, isoform A) (Q9VCB2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLQYKSAASAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQLITIPGTNIQIPVTNLIQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQTANGQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRVACTCPNCTDGEKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAATVAGSTVTPGGATIVQLPTVEASGGGDSFGDDEDDEEDDELTEEDDEDEELDEDDMDDCEDEEDDEDPELDSGDEVKMTIAVSEPGDNSSN
Protein: Varicose (A1XXK1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRWSARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLGSSSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRD
Protein: Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (Q6NW89)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear factor, erythroid 2.
- Nuclear factor, erythroid 2-like 2b.
- Nuclear factor
Sequence:
MTTTNKGNKALKVKREPGENGTSLTDDELVSMSVRELNQHLRGLSKEEILQLKQRRRTLKNRGYAASCRVKRVTQKEELERQKAELQQEVEKLASENASMKVELDALRSKYEALQSFARTVARGPVVPVSTAAVPVSPRGPLASVIGPLIPGKVGATSVITIVKSKTDARS
Protein: S-adenosylmethionine synthase (EC 2.5.1.6) (Q6FX78)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- adenosylmethionine decarboxylase
- aromatic-amino-acid transaminase
- S-adenosylmethionine synthase
- Candida glabrata strain CBS138 chromosome F complete sequence
- Adenosylhomocysteinase
- 6,7-dimethyl-8-ribityllumazine synthase
- Tryptophan synthase
- Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating
- Histidine biosynthesis trifunctional protein
Sequence:
MAGTFLFTSESVGEGHPDKICDQVSDAILDACLAVDPHSKVACETAAKTGMIMVFGEITTKAVLDYQKIVRDTIKKIGYDASDKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLENIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDESGRWVPQRIDTVVVSAQHADEISTEDLRSKIKTEIIDKVIPADMLDENTKYYIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVETYGTATRPDDEIIEIIKKNFDLRPGILVKELDLARPIYLPTASYGHFTNQEYPWEQPKKLVI
Protein: E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20) (P51774)
Organism: Rattus norvegicus (Rat)
Function: Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P08152}.
Interaction partners:
- Transcription factor SOX-10
- Ngfi-A binding protein 2
- Early growth response protein 3
- Early growth response protein 1
- Histone lysine acetyltransferase CREBBP
- histone acetyltransferase
- Protein c-Fos
- Protein FosB
- NGFI-A-binding protein 1
- Chromodomain-helicase-DNA-binding protein 4
Sequence:
MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAAPSVTIFPNGELGGPFDQMNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPELDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPPTTSTSSLAYQPPPSYPSPKPAMDPGLIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSSSASAQSSASGPGGSQAGGSLCGNSAIGGPLASCTSRTRTP