wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear exosome regulator NRDE2 (Nuclear RNAi defective-2 protein) (G5EG51)
Organism: Caenorhabditis elegans
Function: Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs-mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:20543824, ECO:0000269|PubMed:34365510}. Nucleus speckle {ECO:0000250|UniProtKB:Q9H7Z3}. Nucleus, nucleolus {ECO:0000269|PubMed:34365510}. Note=Accumulation of siRNAs promotes translocation of the protein to the nucleolus. {ECO:0000269|PubMed:34365510}.
Interaction partners:
- Nuclear RNAi defective-3 protein
- ANK_REP_REGION domain-containing protein
- mRNA transport homolog 4
- Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
- Dynein regulatory complex subunit 7
- Argonaute protein hrde-1
- SET domain-containing protein
- Histone-lysine N-methyltransferase set-25
- Chromo domain-containing protein.
- NFX1-type zinc finger-containing protein 1 homolog
Sequence:
MFRAYGNNGLKNPERISGENPDLYTQTRAAVQQRATTTLKRNEKQKLAVQNDSVFQQVGIGESDSDDDNGGVRIRMSPHRYIDPDDVFTLPEVKKQNALRDAKIAARAAQATAYNTFPSVKSLNGCQDPPETSQQSTSRKRSASNSRSPSRSHSRRYDRDNGRQRSRSREKKRRKKERRRKRSSSRSSSSSRSRDRSSRARDTSSHTLMKMNKPAKYAFLTDEEYRTCDAYISSAFITQTKSDCENYTQGVPKKEIAKCRLSVKFIVGLEHNNILFNNIYGAEYARDKENRPFWEQLDRYLKDVPKETFFRYVPPVGGYWKIRDRVDLLNLDHIDDDVLANDSDNRKDAFTFELEQAKKTFSENVHNIDALIKVISMEEEMCRRNVGSFSSSNPAALAERHQEMVKKAIKADGRNAKLRLMKIELLIKMDPNSPTIIDDFKNLTITFPHEPMVWIKYLDYIQYDSNVYNYKKLKNAFEDCIRQVTGLTNGTLLSHLNAVNDRPLLRMFHLWIYIRYLKWMISCAHTPVVLANIQATFEYNFGLADVEKRTSTNSKEREVRLEEFWESGLPRIGDEGAVGAEKMLKQSEELSDEDIQKLENDDFDILISRTEETIATCLQAQRDVQISWIEVEREMMNIDARVKRTKLKDCELYEDHVDDLETCELWDIIPFDRIRYYEAPGDCANFDFVQPFLELLGVKFLNSTNCFTTTEQIISDWISNDSTVNFYKTPTYTEKKCFEVGNNILKFMLYNRLKLTENNPEYLDKTMVKYLLAMLVTEASEQEKKLNFHSFKLNLKNLVGTFITKHPDIFKRAMLSKITGIVYMEKFVSWWERALKEQEKVVEADERRKNYKEIKMEEGVVDDVKFDVILLKKDKERVQTIRDKIRDMIDIAIPKSTEKLIQSADSSLPTLQLHLYANVLRGRLSILNQNALEETRDVFCKEILGIHTSEFESDEALLLALDQGLNELLEHCKEKDNLESVDSIPELPRAEALCEALKVVAVFVFLDKMAFSRRAVDCLIANAITKFEQFEAKKNDFNRGTYEKYCDQIDLKFITDTLITFFSHKKHRFIYNENFKKLIFQASQAFPCDSKYAKMLGELHSSGRLQVMKLQGFTDSRNSILNAKRDQQFDPELETRLLMNSLTIMFSWMNAANRIGDAGNQILYKNWKREAANTRDPAIWRQVIRVASKLSQKILKDDAYTRARGQCTWALNLHFDYIEAKTVRKNGDLMEMIYLILEQSMGQEHSLFVTDEEYMKTQQEIGLQYSESGR
Protein: Germacrene A synthase (LvGEAS) (EC 4.2.3.-) (Beta-elemene synthase) (EC 4.2.3.-) (T1RRJ6)
Organism: Lavandula viridis (Green lavender)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds widely used in aromatherapy and folk medicine, and present in culinary herbs. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into germacrene A and beta-elemene. Not able to use (2E)-geranyl diphosphate (GPP) as substrate.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MAQQEAEILRPLANFSPSLWGDQFIKNDSDAKVRYIFHYVDYTNLSMLTATGTKMVDTMNLIDTLERLGVSYHFEHEIEEILQQFFNLNTDYNDEAYDLYTVATHFRLFRQHGHRITCADIFGRWRDENGKFHEGLKDDAKGLLSLYEASYLRTRGETILDEALDFTTASLKSIAPNLESPLRRQVEHALVQQLHWGNPRIEARNFISLYEEYEDKDESLLRFAKLDYNLLQMMHKEELHEVSRWWKELDLVAKLPYARDRVVECFFWAMGVYHEPQYSRARVMLTKTIAMTSIIDDTYDAYGTIEELDIFTEAIERWNVEEMKRLPEYIKPFYKALLELYEQFEEELAKEGRSYATHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVREDFEWLSKKPKMLVAGLLICRVIDDIATYEVEKDRGQIATGIESYMRDNGATKEEAITKFFEIANDAWKDINEECMRPSPHSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIQI
Protein: Nonsense-mediated mRNA decay protein 3 (Up-frameshift suppressor 3) (Q10267)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nonsense-mediated mRNA decay protein 2
- ATP-dependent helicase upf1
- Protein mago nashi homolog
- ATP-dependent RNA helicase fal1
- mRNA export factor mex67
- Uncharacterized RNA-binding protein C23A1.09
- Nuclear cap-binding protein subunit 1
- Uncharacterized serine-rich protein C2F12.03c
- Eukaryotic peptide chain release factor GTP-binding subunit
- Nuclear cap-binding protein subunit 2
Sequence:
MAPDISKKRLPCKVLVFNLPPTLPEQVFLQSINSFLPHVEWHRFSKGKATVGTRSELLSFAYLKFQSATAVQEFFRVYQGHTFIDKKNNTYRAIVTIAPYQKIPPSKVKADSLEGSLEQDPKFQEFKVQRESYSQTASNDDVIEKLQTSTPLLQYLAEKKNAVVEKGKSKPSKKSVKAKKKLRLAEKPASNNSKAGKSSQESKKSSKAPAESAAAVIKEDKVSDRKKSKKKPKKTPVSNSTASQASENASDKKTKEKKSSGKQKIASKKKDQLTTDNV
Protein: Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Q9CWU2)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18794299, ECO:0000269|PubMed:19299482, ECO:0000269|PubMed:25253725}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18794299}; Multi-pass membrane protein {ECO:0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO:0000269|PubMed:18794299}.
Interaction partners:
- Huntingtin
- Palmitoyltransferase ZDHHC6
- Synaptosomal-associated protein 25
- Palmitoyltransferase ZDHHC11
- Palmitoyltransferase ZDHHC21
Sequence:
MEGPGLGSQCRNHSHGSHVPGFGRHGICVHENKELAKAKEILPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDRENVSLLHWAAINNRLELVKFYISKGAVIDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLSVVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHKCELFLLLILSMITLWAVGYILDFNSDSWLLKGCLLVALFFLTSLFPRFLVGYKNLVYLPTVFLLSSIFWIFMTWFILFFPDTAGSPLYFAFIFSIMAFLYFFYKTWATDPGFTKASEEERKVNIVTLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFKEDGLWTYLNQIVACSPWVLYIFMLAAFHFSWSTFLLINQLFQIAFLGLTSHERISLLKQSRHMKQTLSLRKTPYNLGFTQNLADFFQCGCFGLVKPCIIDWTSQYTMVFHPAKEKVLRSV
Protein: Mediator of RNA polymerase II transcription subunit 31 (D4A7J4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364129}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 11
Sequence:
MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKEPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNTTAGK
Protein: Anthrax toxin receptor (F1LT78)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Coiled-coil domain-containing protein 71
Sequence:
MVAGRSRARSPGSWLFPGLWLLTVGGPGSLLQAQEQPSCKKAFDLYFVLDKSGSVANNWIEIYNFVHQLTERFVSPEMRLSFIVFSSQATIILPLTGDRYKISKGLEDLKAVQPVGETYIHEGLKLANEQIQNAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKKSRSLGASVYCVGVLDFEQAQLERIADSKDQVFPVKGGFQALKGIINSILAQSCTEILELSPSSVCVGGKLIIITTGRMTSLPVTLVLLLGFSISSQYLMSRNFSVVQPGSILCPAPVLNKAGETLEVSIAFNDGKSAVSRSLTITATECSNGIAAIIAILVLLLLLGAALMWWFWPLCCKVVRRIFNSYFLYKEEEEEPLPNKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVMIPEEEIPVPSRPPRPKPTHQAPQTKWYTPIKGRLDALWALILKQYDRVSLMRPQEGDEVPNFIPLPFQIIK
Protein: Alpha-glucosidase (AGL) (EC 3.2.1.20) (Maltase) (Q12558)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Hydrolyzes malto-oligosaccharides, but has a low activity toward soluble starch.
Interaction partners:
- Glucoamylase
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- Alpha-amylase A type-1/2
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- glucan 1,4-alpha-glucosidase
- alpha-amylase
- Probable alpha-galactosidase A
- Glycosyl hydrolase
- Probable alpha-galactosidase B
Sequence:
MAGLKSFLASSWLLPVACGASQSIVPSTSATAAYSQFTIPASADVGANLVANIDDPQAVNAQSVCPGYKASDVKHSSQGFTASLELAGDPCNVYGTDVDSLTLTVEYQAKDRLNIQIVPTYFDASNASWYILSEELVPRPKASQNASVPQSDFVVSWSNEPSFNFKVIRKATGDVLFNTKGSTLVYENQFIEFVTLLPEEYNLYGLGERMNQLRLLENANLTLYAADIADPIDDNIYGHHAFYLDTRYYKVGGQNKSHTIVKSSEAEPSQEYVSYSHGVFLRNAHGQEILLRDQKLIWRTLGGSVDLTFYSGPTQAEVTKQYQLSTVGLPAMQQYNTLGFHQCRWGYNNWSEFEDVLANFERFEIPLEYLWADIDYMHGYRNFDNDQHRFSYEEGEKFLNKLHAGGRRWVPIVDGALYIPNPENASDAYETYDRGAKDDVFIKNPDGSLYIGAVWPGYTVYPDWHHPKASDFWANELVTWWNKLHYDGVWYDMAEVSSFCVGSCGTGNLSMNPAHPPFALPGEPGNVVYDYPEGFNITNATEAASASAGAASQSAAASSTTTSAPYLRTTPTPGVRNVDHPPYVINHVQPGHDLSVHAISPNSTHSDGVQEYDVHSLYGHQGINATYHGLLKVWENKRPFIIARSTFSGSGKWAGHWGGDNFSKWGSMFFSISQALQFSLFGIPMFGVDTCGFNGNTDEELCNRWMQLSAFFPFYRNHNVLSAIPQEPYRWASVIDATKAAMNIRYAILPYFYTLFHLAHTTGSTVMRALAWEFPNDPSLAAVGTQFLVGPSVMVIPVLEPQVDTVQGVFPGVGHGEVWYDWYSQTAVDAKPGVNTTISAPLGHIPVFVRGGSILPMQEVALTTRDARKTPWSLLASLSSNGTASGQLYLDDGESVYPEDTLSVDFLASRSTLRASARGTWKEANPLANVTVLGVTEKPSSVTLNGETLSSDSVKYNATSHVLHVGGLQKHTADGAWAKDWVLKW
Protein: Inducible ornithine decarboxylase (EC 4.1.1.17) (P24169)
Organism: Escherichia coli (strain K12)
Function: The first enzyme leading to putrescine and thus polyamine synthesis.
Interaction partners:
- Putrescine transporter PotE
- Polyamine aminopropyltransferase
- Agmatinase
- Putrescine aminotransferase
- Gamma-glutamylputrescine synthetase PuuA
- Spermidine N
- Constitutive ornithine decarboxylase
- Cadaverine/lysine antiporter
- S-adenosylmethionine decarboxylase proenzyme
Sequence:
MSKLKIAVSDSCPDCFTTQRECIYINESRNIDVAAIVLSLNDVTCGKLDEIDATGYGIPVFIATENQERVPAEYLPRISGVFENCESRREFYGRQLETAASHYETQLRPPFFRALVDYVNQGNSAFDCPGHQGGEFFRRHPAGNQFVEYFGEALFRADLCNADVAMGDLLIHEGAPCIAQQHAAKVFNADKTYFVLNGTSSSNKVVLNALLTPGDLVLFDRNNHKSNHHGALLQAGATPVYLETARNPYGFIGGIDAHCFEESYLRELIAEVAPQRAKEARPFRLAVIQLGTYDGTIYNARQVVDKIGHLCDYILFDSAWVGYEQFIPMMADCSPLLLDLNENDPGILVTQSVHKQQAGFSQTSQIHKKDSHIKGQQRYVPHKRMNNAFMMHASTSPFYPLFAALNINAKMHEGVSGRNMWMDCVVNGINARKLILDNCQHIRPFVPELVDGKPWQSYETAQIAVDLRFFQFVPGEHWHSFEGYAENQYFVDPCKLLLTTPGIDARNGEYEAFGVPATILANFLRENGVVPEKCDLNSILFLLTPAEDMAKLQQLVALLVRFEKLLESDAPLAEVLPSIYKQHEERYAGYTLRQLCQEMHDLYARHNVKQLQKEMFRKEHFPRVSMNPQEANYAYLRGEVELVRLPDAEGRIAAEGALPYPPGVLCVVPGEIWGGAVLRYFSALEEGINLLPGFAPELQGVYIEEHDGRKQVWCYVIKPRDAQSTLLKGEKL
Protein: 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) (P97532)
Organism: Rattus norvegicus (Rat)
Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9749958}. Mitochondrion {ECO:0000269|PubMed:9749958}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q99J99}.
Interaction partners:
- Cystathionine gamma-lyase
- Sulfite oxidase, mitochondrial
- Ethylmalonic encephalopathy 1
- Adenylyltransferase and sulfurtransferase MOCS3
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Cysteine desulfurase
- Cystathionine beta-synthase
- L-lactate dehydrogenase B chain
- Kynurenine--oxoglutarate transaminase 1
Sequence:
MAAPQLFRALVSAQWVAEALKSPRASQPLKLLDASWYLPKLGRDARREFEERHIPGAAFFDIDRCSDHTSPYDHMLPSATHFADYAGSLGVSAATHVVIYDGSDQGLYSAPRVWWMFRAFGHHSVSLLDGGFRYWLSQNLPISSGKSPSEPAEFCAQLDPSFIKTHEDILENLDARRFQVVDARAAGRFQGTQPEPRDGIEPGHIPGSVNIPFTEFLTSEGLEKSPEEIQRLFQEKKVDLSKPLVATCGSGVTACHVVLGAFLCGKPDVPVYDGSWVEWYMRAQPEHVISQGRGKTL
Protein: Protein lin-28 homolog (Q9VRN5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Ribonuclease 3
- Dis3 like 3'-5' exoribonuclease 2, isoform C
- Endoribonuclease Dcr-2
- LD23072p
- Heterogeneous nuclear ribonucleoprotein A1
- Protein argonaute-1
- Datilografo, isoform A
- LD26789p
Sequence:
MENVQLENGLERRTTSQSSTSSANPANLASPTEECGCVRLGKCKWFNVAKGWGFLTPNDGGQEVFVHQSVIQMSGFRSLGEQEEVEFECQRTSRGLEATRVSSRHGGSCQGSTYRPRINRRTRRMRCYNCGEFANHIASECALGPQPKRCHRCRGEDHLHADCPHKNVTQSHSNSKSISNNSSSSAAQEKSEEAT
Protein: Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase) (Q9V3N8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
Interaction partners:
- Serine/threonine-protein kinase Tao
- histidine--tRNA ligase
Sequence:
MACSRFEYVKSFEQDDSILPNVWIVIRIDGKKFHKFSKTHDFEKPNDENALNVMNAAATAVMQEFRDIVLAYGQSDEYSFVFRKETAAFKRRSAKLLTYVTSLFSSSYVMQWSKWMNLPLAYAPCFDGRVVLYPSEQNLKDYLSWRQADVHVNNLYNTAFWKLVLEKGLTNQQAEAKLRGTFSADKNELLFQEFGINYNNLPAMYRKGTILLRKRVILGEKSRQAVVPLHEDLISSQFWKEHTEILGKYVPGTYDAPQTFPRLVEMQINGKDDNEAEEPQNLAGTS
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (P9WNL1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00318}. Secreted {ECO:0000255|HAMAP-Rule:MF_00318, ECO:0000269|PubMed:37385399}. Cell surface {ECO:0000255|HAMAP-Rule:MF_00318, ECO:0000269|PubMed:27569900}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface (PubMed:27569900, PubMed:37385399). Detected by antisera of human patients infected with tuberculosis (PubMed:27569900). {ECO:0000269|PubMed:27569900, ECO:0000269|PubMed:37385399}.
Interaction partners:
- Pyruvate kinase
- Phosphoglycerate kinase
- Glucose-6-phosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
- Fructose-bisphosphate aldolase
- Triosephosphate isomerase
- Transaldolase
- Transketolase
- Glutamate synthase large chain
Sequence:
MPIIEQVRAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALALDAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLAFPRFACETK
Protein: Vacuolar basic amino acid transporter vsb1 (Q09764)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:35289847}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable sulfate permease C3H7.02
- Probable sulfate permease C869.05c
- Vacuolar heme ABC transmembrane exporter abc3
- GTP-binding protein ypt1
- Putative glutamine amidotransferase PB2B2.05
- Protein isd11
Sequence:
MPTHSLNQKRSLLYPSIDNGSVPDSSFLSQSFRDTNDIHLLSARLASVEVDPETLPSNSPETNDDVSNYDYMSISSYQRAHSLASTSRNDFNYRPSEINETRPLLPEREEHSSQLPPAQNQVLPFQSLNAPSKKLRGRISLSKIYQFFFDDKGPILFILNIPAVIIGLLLNILDALSYGLILFPISDPLFKNLGADGLAIYYVSCVVSQLVYSLGGSFFKGSVGSEMIEVIPFFHQIAFTILNRVGEDNPKSVIATTILAYCLSSILTGLVFFILGILRLGRLIEFFPRHILLGCIGGVGSFLVLTAVEVSSRLEGSVSFNWASLSALFQPMTFAKWSIPLFLSSALEFAQQRWPHPFLIPSFFVIAPAIFYVLVWAIPGMSLEYLRETGWVFSSTETNVPWYHFYSLFSLRDTDWSALLATVPEMCALTFFGILHVPINVPALAISLGLDFVDTDKELIAHGVSNTLSGAVGSIQNYMTYTNSLMFIRSGGNNRLAGIMLALATVALLVIGPGIIAYIPVWTVGCLIYLLGIELLKESLWDPIGITTKIEYFTICAIVFTMTVVDFVVGIVIGIIMACVFFVIQASSRSALRGIYSGGIVRSTVRRPMNQQRFLNEIGRQIQVCKLSGFLFFGTINGVEKNIAGLIEELNVSNNPLRFLIIDFSLVNGADFSVVQAFLRIRRMLATMNVQLCVCGLDETRSSFKTLTTMCFGGDDNCGCQVFEDVNSSLEYCENMLLDDYDVYRTKLLHKAGYSHTLAVPGKHKQNISMAETFSPSPRHDLLRQVAMSSVKAETKELSKFEKYAKYEQPFPLLMQVFGEITTKREDFWLGLCPFFKKAFLRKGDLLWRKGDTPSKLVILETGMVKASYQMDRESLSENITCLCVVGELPFFSKTCYNATVVAELDSAVWILDREGWETMLKSSDKAEVIENEMLYLTLKMTRDKFNVFTNFALNLYR
Protein: Dynein axonemal assembly factor 1 homolog (Defective transmitter-recycling protein) (Leucine-rich repeat-containing protein 50 homolog) (Q8INT5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cilium-specific protein required for cilia structures.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Putative inner dynein arm light chain, axonemal
- Radial spoke head protein 9 homolog
- Uncharacterized protein, isoform B
- GH13165p
Sequence:
MSNSNRKEITGLNRMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDSEDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYDIFAAEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDIMINLLPKTKEKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQNLIGISIDETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNESDQDDKQDQLFAKILDDATENIPKRIFGTGCDALSSVWPQEECLLQLTLPENKESPAQEDTFKKSITNSTSFEKANEICVRMDQKMAEEEEALGKLLHDLEGEINNVYDINTKVKYEENTSTNESDAVSICTSLLDDIIVGLTFDEVLCHEKPKSFEFGLIESDEEFSYSFEPKLEKLVPPALEDPARGKSLRECLDTFSDFVSSMADPKLPVMLGRNPTSGVEKIRAAQELLKTKNLSDLYKDTAESLNSQVAKEIEKRKRRVAASATRCFNQRDKYDDTLELVENRLMIVKKDSGDLEELPPPPPLISDTESEDDNPTEDNYTPGNEVHRHGTKTQDSKEHLMSNLLNQNQDDIIEGKKNDSAEDEFYSLEAMTTFGNLDAEFFQKLDLQKVNASEDSEPAINCMRSYNELQAYMKSGSLNTQLNSEEAEMLQTMCSRVASDVDKPKSQNSKEEEEDDLLKKMVLRMKEYEEREHQLQLISHETSSELGPIKLSIGGSKLFEQNTKIPESVLVHSENEPTRNNKPINTKNTNDKESSDIMEKNGDPSVTTSFKTSHKSIDDDIQSDVSTDYESGEEVVVVEPPTLSEAVLKSFYSDEFEADSKMVHELEEATRRNLRRYNPNIMHISTSNHPFSTNNILPTKTSTSELSEGAKAKWAKIAERLHEFLDPETIANLNKEQFGESDECEDSQDDNITDITVEETNLKKDTKLVVLEEYNNTHTCDGNSCPSKLDDSDQFASLKGFEKIKETPTHNMGLSSVMSASQNKTSETLPNEIGNKITDFSSFKTSSTDLINSEGVKTEQIQCNLQILSDEGDVVVEELSVNAQVSSFK
Protein: Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C) (Q96DT6)
Organism: Homo sapiens (Human)
Function: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}.
Interaction partners:
- Gamma-aminobutyric acid receptor-associated protein
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Microtubule-associated protein 1 light chain 3 beta
- Ubiquitin-like-conjugating enzyme ATG3
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Ubiquitin-like-conjugating enzyme ATG10
- Microtubule-associated protein 1 light chain 3 gamma
Sequence:
MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
Protein: At1g64680 (Beta-carotene isomerase D27) (F1N19.25) (Q9SGU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetraspanin-17
- At1g67350
- RNA-processing, Lsm domain-containing protein
- PGR5-like protein 1A, chloroplastic
- Myosin
Sequence:
MAAIASLQAVNLTFRRRSTRCGIAEPSGEPAPMGLKTRYEDGLVERVFMGLFARKMDKFGSKKKKDTKEKGFWEYDYESFVEVSKRVMQGRSRVQQQEAVREVLLSMLPPGAPEQFRKLFPPTKWAAEFNAALTVPFFHWLVGPSQVIEVEVNGVKQRSGVRIKKCRYLENSGCVGMCVNMCKIPTQDFFTNEFGLPLTMNPNYEDMSCEMIYGQAPPAFEEDVATKQPCLADICSMSNPSSPICPKLEA
Protein: Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Q63486)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7L523}. Nucleus {ECO:0000250|UniProtKB:Q7L523}. Lysosome membrane {ECO:0000250|UniProtKB:Q7L523}. Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. {ECO:0000250|UniProtKB:Q7L523}.
Interaction partners:
- Ras-related GTP-binding protein
- Ras-related GTP-binding protein
- NPR2-like, GATOR1 complex subunit
- Serine/threonine-protein kinase mTOR
- GATOR complex protein NPRL3
- DEP domain containing 5, GATOR1 subcomplex subunit
- Folliculin
- Regulatory-associated protein of mTOR
- Ragulator complex protein LAMTOR1
- Folliculin interacting protein 2
Sequence:
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
Protein: PVR adaptor protein (RE37138p) (Q9VRS2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPKSEAATMITNNNLDYDQASASSTIIAGATSTTAGTAATSVAMSNRNGSTSSSSNSSPTADNSNSNSNSNSNANINRNLNQNPNSNSNTNSNSYFNRFDNRIAANLAAVLTGAGARFRSSSCSNRHPAGVANPAVLRSPLATISRKTSLATPPSPASLGRRRPLQLFTHANLNCNDNEKVAQTPSSDEDNSPTELNSCKRLADKPPLVKRLTMGLLRQNEESRPLVGDMTPLSAPLDIQPVYSNGYINEDSYIDSKFGDSCRQSLTAIPMLDNVNLNDNNEFNLKKRYLRETSSANSSPKIFANRLRMNQGAVGQRCSSLANAFGNVGSDEEDLELKDACWYQAGISRDIAVEVLQSKSPGAFLVRKSSSKPGCYALTLRVPSPPGPKIANYIILRSPRGYKIKGFRKEFSSLKALITHHSVMPELLPVPLAMPRPTNMSSSRRNLDDFDTYDSLQMLLKYLRAKNMETEQQQ