wanglab/gogpt-training-data huggingface dataset:
Protein: Pumilio RNA binding family member 2 (A0A0C4DG68)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
RFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVIQKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML
Protein: Uncharacterized protein (Q38DX4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVLRLPKDELDAQVYRYLRESNYIEAADALKASNPSVEKAGRGLKFSALIAAPKNIRDKTDSDDDEPVRKPAKRSPKFAPKKPMPESDSDDDEPVRKPVKASPKVAPKKPMPESDSDDDEPVRKPVKASPKVAPKKPMPESDSDDDEPVRKPAKRSPKVAPKKPMPESDSDDDEPVRKPVKASPKVAPKKPMPESDSDDDEPVRKPVKASPKVAPKKPMPESDSDDDEPVRKPVKASPKVAPKKPMPESDSDDDEPVRKPAKRSPKVAPKKPMPESDSDDDEPVRKPAKRSPKVAPKKPMPESDSDDDEPVRKPVKASPKVAPKKPMPESDSDGEEVQQNANGKRSIGDDEEGEDEPVRKFIRNENGNGRGRGRGRDFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGDRGGRGFGRPSPSFDNNRNTTRFDDSD
Protein: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) (Q10469)
Organism: Homo sapiens (Human)
Function: Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-mannosidase 2
- Alpha-mannosidase 2x
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
- Alpha-
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSVAVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSFYGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVVAISPPRKNGGWGDIRDHELCKSYRRLQ
Protein: Transcriptional regulatory protein CreB (P08368)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor protein CreC
- Protein CreA
- Inner membrane protein CreD
- Signal transduction histidine-protein kinase BaeS
- Sensor histidine kinase HprS
- Sensor histidine kinase ZraS
- Sensor protein BasS
- Phosphate regulon sensor protein PhoR
- Sensor histidine kinase CusS
- Sensor protein RstB
Sequence:
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARKQVPDVMILDVGLPDISGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLALTRYEFLLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL
Protein: Pre-mRNA-splicing factor CWC2 (Complexed with CEF1 protein 2) (PRP19-associated complex protein 40) (Synthetic lethal with CLF1 protein 3) (Q12046)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Binds also to U1, U4, U5 and U6 snRNAs and to pre-mRNAs, in vitro. Is not required for the Prp2-mediated remodeling of the activated spliceosome.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor NTC20
- Pre-mRNA-splicing factor CWC21
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor SNT309
- Pre-mRNA-splicing factor SPP2
- Pre-mRNA-splicing factor SLT11
- Pre-mRNA-splicing factor ISY1
Sequence:
MTSWRDKSAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSPFALQPQLHSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDIGKLALRTEVLDCFGREKFADYREDMGGIGSFRKKNKTLYVGGIDGALNSKHLKPAQIESRIRFVFSRLGDIDRIRYVESKNCGFVKFKYQANAEFAKEAMSNQTLLLPSDKEWDDRREGTGLLVKWANEDPDPAAQKRLQEELKLESLNMMVHLINNNTNSAGTEVNNKNNERLDRTFPEASVDNVKKRLLPLDNGMESDDFIEKLKKVKKNISRENISSKPSVGKLGGPLLDYLSSDED
Protein: MHC class I antigen splice variant Bl.1 (Q4VCN9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAQRTLLLLLAAALTMIQTRAGPHSMRYFETAVFGPGLGEPRFISVGYVDNTQFVSFDSDAENPRSEPRSPWMEQEGPEYWERETQIAKDNEQSFGWSLRNLIHYYNQSKGGFHTFQRLSGCDMGLDGRLLRGYLQFAYDGRDYIALNEDLKTWMAADLVALITRRKWEQAGAAELYKFYLEGECVEWLRRYLELGNETLLRTDPPKAHVTRHPRPAGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQNYTCRVHHEGLPEPLTLRWEPPPSTGSNMVNIAVLVVLGAVIIIEAMVAFALKSRRKIAILPGPAGTRGSSAS
Protein: Surface presentation of antigens protein SpaR (P40701)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Surface presentation of antigens protein SpaP
- SPI-1 type 3 secretion system secretin
- Surface presentation of antigens protein SpaS
- Invasion protein InvA
- Surface presentation of antigens protein SpaQ
- Lipoprotein PrgK
- SPI-1 type 3 secretion system ATPase
- Surface presentation of antigens protein SpaN
- Surface presentation of antigens protein SpaK
- Surface presentation of antigens protein SpaM
Sequence:
MFYALYFEIHHLVASAALGFARVAPIFFFLPFLNSGVLSGAPRNAIIILVALGVWPHALNEAPPFLSVAMIPLVLQEAAVGVMLGCLLSWPFWVMHALGCIIDNQRGATLSSSIDPANGIDTSEMANFLNMFAAVVYLQNGGLVTMVDVLNKSYQLCDPMNECTPSLPPLLTFINQVAQNALVLASPVVLVLLLSEVFLGLLSRFAPQMNAFAISLTVKSGIAVLIMLLYFSPVLPDNVLRLSFQATGLSSWFYERGATHVLE
Protein: Monothiol glutaredoxin-S17 (AtGrxS17) (Q9ZPH2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides (Probable). Participates probably to the maturation of iron-sulfur proteins and to the regulation of the redox state of the BOLA proteins. The GRXS17-BOLA2 heterodimer binds a labile, oxygen sensitive iron-sulfur cluster.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein BOLA2
- Anamorsin homolog
- Protein BOLA1
- Protein BOLA4, chloroplastic/mitochondrial
- SufE-like protein 1, chloroplastic/mitochondrial
- MMS19 nucleotide excision repair protein homolog
- Protein NAR1
- Protein AE7
- At3g12480/MQC3.32
- E3 ubiquitin-protein ligase RGLG3
Sequence:
MSGTVKDIVSKAELDNLRQSGAPVVLHFWASWCDASKQMDQVFSHLATDFPRAHFFRVEAEEHPEISEAYSVAAVPYFVFFKDGKTVDTLEGADPSSLANKVGKVAGSSTSAEPAAPASLGLAAGPTILETVKENAKASLQDRAQPVSTADALKSRLEKLTNSHPVMLFMKGIPEEPRCGFSRKVVDILKEVNVDFGSFDILSDNEVREGLKKFSNWPTFPQLYCNGELLGGADIAIAMHESGELKDAFKDLGITTVGSKESQDEAGKGGGVSSGNTGLSETLRARLEGLVNSKPVMLFMKGRPEEPKCGFSGKVVEILNQEKIEFGSFDILLDDEVRQGLKVYSNWSSYPQLYVKGELMGGSDIVLEMQKSGELKKVLTEKGITGEQSLEDRLKALINSSEVMLFMKGSPDEPKCGFSSKVVKALRGENVSFGSFDILTDEEVRQGIKNFSNWPTFPQLYYKGELIGGCDIIMELSESGDLKATLSE
Protein: Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114) (P40223)
Organism: Mus musculus (Mouse)
Function: Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Granulocyte colony-stimulating factor
- Tyrosine-protein kinase JAK2
- Granulocyte-macrophage colony-stimulating factor
- CCAAT/enhancer-binding protein alpha
- Transcription factor PU.1
- Erythropoietin
- Thrombopoietin
- Tyrosine-protein kinase JAK1
- Signal transducer and activator of transcription 3
- Tyrosine-protein kinase JAK3
Sequence:
MVGLGACTLTGVTLIFLLLPRSLESCGHIEISPPVVRLGDPVLASCTISPNCSKLDQQAKILWRLQDEPIQPGDRQHHLPDGTQESLITLPHLNYTQAFLFCLVPWEDSVQLLDQAELHAGYPPASPSNLSCLMHLTTNSLVCQWEPGPETHLPTSFILKSFRSRADCQYQGDTIPDCVAKKRQNNCSIPRKNLLLYQYMAIWVQAENMLGSSESPKLCLDPMDVVKLEPPMLQALDIGPDVVSHQPGCLWLSWKPWKPSEYMEQECELRYQPQLKGANWTLVFHLPSSKDQFELCGLHQAPVYTLQMRCIRSSLPGFWSPWSPGLQLRPTMKAPTIRLDTWCQKKQLDPGTVSVQLFWKPTPLQEDSGQIQGYLLSWSSPDHQGQDIHLCNTTQLSCIFLLPSEAQNVTLVAYNKAGTSSPTTVVFLENEGPAVTGLHAMAQDLNTIWVDWEAPSLLPQGYLIEWEMSSPSYNNSYKSWMIEPNGNITGILLKDNINPFQLYRITVAPLYPGIVGPPVNVYTFAGERAPPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYTIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAGSTNSTGLTLRTLDPSDLNIFLGILCLVLLSTTCVVTWLCCKRRGKTSFWSDVPDPAHSSLSSWLPTIMTEETFQLPSFWDSSVPSITKITELEEDKKPTHWDSESSGNGSLPALVQAYVLQGDPREISNQSQPPSRTGDQVLYGQVLESPTSPGVMQYIRSDSTQPLLGGPTPSPKSYENIWFHSRPQETFVPQPPNQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF
Protein: Dof zinc finger protein DOF4.5 (AtDOF4.5) (O49550)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ethylene-responsive transcription factor ERF069
Sequence:
MDNLNVFANEDNQVNDVKPPPPPPRVCARCDSDNTKFCYYNNYCEFQPRYFCKNCRRYWTHGGALRNIPIGGSSRAKRARVNQPSVARMVSVETQRGNNQPFSNVQENVHLVGSFGASSSSSVGAVGNLFGSLYDIHGGMVTNLHPTRTVRPNHRLAFHDGSFEQDYYDVGSDNLLVNQQVGGYGYHMNPVDQFKWNQSFNNTMNMNYNNDSTSGSSRGSDMNVNHDNKKIRYRNSVIMHPCHLEKDGP
Protein: Uncharacterized protein (Q581S8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWGGVKVRAHHRDIFRAWSASQNLETLRRQLYREPRPWYMAFKLHQHRHLLSDYHCARLLSWCTAVVQLERRPVPKRKAYMYAQHVFQFMVHSHKVGKESYQEFFRLCALGRDVTAAFRWQQYLVEAGQSFPLSHYTWLLHIAAASPSDEITEDMTEGVWEAYLGRYCSPVKNDVTGQTAMAHFQPTTSEEQQELEGLFAAFKALKLRIEPTAKPELLQFIDNLPNTPQVVPGATSWPTVSRHTIFPHMEAAVPWEAPTLVQPRLRDSLLHPSFVADLERTAWTGDVKGVVALVNEYRQRITAEKEQTSATKHRSGERDIWRHYADPAAVAFRRVLVEEGGVTAELYHYLIVALSATQPSLALRTLRRMENAKLRVLDLTRAVMIVRSEGSSEEQLNLLKEGLKSIEERCKIDEDYDVTREVELYWKFNYAEFFHYRNALNGVELYRILMEGLGPVRVQELLVGAKGAVSYPSEDVVVFDEVFRIAVARHYRNCTGEAEVERALDEITQHMPKLDISLVGSCQHFDGYALPPSDAVATDITSLARKLLGYHTIYLLDSSFVESSEAFLGLGSLNEEENGGHSLVLVPYFCLRQISSVLDAPDGEVVSYDEALQEVGKEDQFIASQRLRSLYALLLNDKGNVKRRVLHFSECLLSQIVTGAVDSAGSDNDHLLLVLAMVRAIAPKETNVVLCTDDAHLVQRLRHDEVASLFAGQVNVLSSEPPEGAVIGEGGLVDDNPNLCVGLDFEPKLNFPAAPRRVTGAGEGSVKAADSAHLHTLCGEEVREGGVSWLDMLGDDEDSGKNSEGSVSALLPVNLTENEEKSAQDQMKLMDMYESEHSVVPIGVRMAEASTLGSLFEQFDAVNPDAALEREAAAAAAAAASRKEPGEAHKKHRRLAPLELEQLRNRGASNKQRYRLARRLSNLAGGRVPFNFRYKVVEVDITDERNKTYRDAYSNAVAKKREAFKRHLQR
Protein: Transcription termination factor 1, mitochondrial (Mitochondrial transcription termination factor 1) (mTERF) (mTERF1) (Q99551)
Organism: Homo sapiens (Human)
Function: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.
Subcellular location: Mitochondrion.
Interaction partners:
- Dimethyladenosine transferase 2, mitochondrial
- Transcription termination factor 3, mitochondrial
- Transcription elongation factor
- Dimethyladenosine transferase 1, mitochondrial
- DNA-directed RNA polymerase, mitochondrial
- GA-binding protein alpha chain
- Transcription termination factor 4, mitochondrial
- GA-binding protein subunit beta-1
Sequence:
MQSLSLGQTSISKGLNYLTIMAPGNLWHMRNNFLFGSRCWMTRFSAENIFKSVSFRLFGVKCHNTDSEPLKNEDLLKNLLTMGVDIDMARKRQPGVFHRMITNEQDLKMFLLSKGASKEVIASIISRYPRAITRTPENLSKRWDLWRKIVTSDLEIVNILERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNAPRTFSNSLDLNKQMVEFLQAAGLSLGHNDPADFVRKIIFKNPFILIQSTKRVKANIEFLRSTFNLNSEELLVLICGPGAEILDLSNDYARRSYANIKEKLFSLGCTEEEVQKFVLSYPDVIFLAEKKFNDKIDCLMEENISISQIIENPRVLDSSISTLKSRIKELVNAGCNLSTLNITLLSWSKKRYEAKLKKLSRFA
Protein: Headcase protein [Cleaved into: Headcase short protein] (Q9N2M8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function.
Subcellular location: Cytoplasm.
Interaction partners:
- FI18007p1
- RING finger protein unkempt
Sequence:
MAPRRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAPMQGTGGVGGVGGGGMVHCCLPSGDCRKLDTLIHLNELSLADCIRVLCNNENCSAGQYMHRECFEWWEASVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQLRKDLDWVPPSSQGVIYLNGSGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGGGGGGAGVNGNTKTPLSNNNGNSYAGLTPNPNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILNTNNVLGLDLRARAGSLSSSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPAFGSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISNFKPLASYEQQQLVQQQKNKEVELYSDRVRSTSGCNGIFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQRLSFYSDYSHGVTCPYCNTQDTHFVKPLTFCYAKTTATRLPTLAXHEAPLESPVGTGATTTQVPNAQGSPTASGCSSNTIASKQPPKQPLYNAAIDYSAPLQQQINPDLIGAHPHAQQHQQQVRQQQQQQQQQQPQQQQQQQQQQTQQQQSQQQQQQQQQQHQPVVSTFQRGNFPQQSHKTMNMMAMADVMSKYQQQQHQQQQQQRQQQHNLQPQQQHATQKGLEGLLLTNTNTSNNNSSSSSSSSISNLIISHNSASNTGNKMQPTWGQSDAISALWGCSSSSSGCSSGSGSQPSLSPTASSNGNDGSKMMLWAAQSSPQNAATLRDGFKELQRQQPPQQQVPQQQPHAASPTASLTSSSSSSNGWSASHYGKPNIWELPGSTGQRTPASSHDIFTDLLCNLSISQDNSSQQASSKADASDVSSNSSSSAGELLEAANIWRFPEYASSQLYMEEPTGGAAACMQLFNDYLNMN
Protein: Cytochrome c oxidase subunit 7B, mitochondrial (Cytochrome c oxidase polypeptide VIIb) (P56393)
Organism: Mus musculus (Mouse)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000269|PubMed:34616041}.
Interaction partners:
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 6B1
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome b-c1 complex subunit 10
- Cytochrome c oxidase subunit 5A, mitochondrial
Sequence:
MLPLAKNALSRLQVRSIQQVVARQSHQKRAPSFHDKYGNAILAGGAIFCVSTWTYTATQIGIEWNMSPVGRVTPKEWRDQ
Protein: T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) (Q495A1)
Organism: Homo sapiens (Human)
Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:23154388}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}. Note=Clustered to the immunological synapse where it disrupts granule polarization and cytotoxicity of NK cells once engaged with PVR. {ECO:0000269|PubMed:23154388}.
Interaction partners:
- Nectin-2
- Poliovirus receptor
- Nectin-3
- CD226 antigen
- Nectin-1
- Galectin-9
- Programmed cell death 1 ligand 1
- T-cell surface protein tactile
- Lymphocyte activation gene 3 protein
- Galectin-9C
Sequence:
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG
Protein: Transcription factor BHLH133 (Basic helix-loop-helix protein 133) (OsbHLH133) (bHLH transcription factor bHLH133) (Q2QQ32)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that acts as regulator of iron homeostasis. May act as negative regulator of iron transportation from root to shoot. Does not seem to be involved in the suppression of the induction of iron deficiency responsive genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22755510}.
Interaction partners:
Sequence:
MECSSFEAICNESEMIAHLQSLFWSSSDADPCFGSSSFSLISSEGYDTMTTEFVNSSTNVCFDYQDDSFVSAEETTIGNKRKVQMDTENELMTNRSKEVRTKMSVSKACKHSVSAESSQSYYAKNRRQRINERLRILQELIPNGTKVDISTMLEEAIQYVKFLHLQIKLLSSDEMWMYAPLAFDSGNNRLYQNSLSQE
Protein: Kidins220 protein (Q8K0P2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
DNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSICSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTGFGEERESIL
Protein: Candida glabrata strain CBS138 chromosome B complete sequence (Q6FXJ6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- DNA-binding protein RAP1
- ATP-dependent DNA helicase II subunit 1
Sequence:
MSDGSADRKGKMRALDILSKHLRGKNSDKTTPTRYGHKSVELESILRKDNIVSSPLESRDHQESQRINNPHSNTASPTPKRRKLNTQAISSDNKTKQVLSIGELSHPDMQSTPARSRIMKKDIGDQNMSSSEIYSPSVNKSVSFLDESNKNSESTSSNSSPRHSPTSKPKKSILRNSSSPEHNKQRMNDKYGKPIAANVHLSRSENHSKNQYSPDNLQFWGNGEIHSLSSNNSVAEFEKLFLGALKILMQSKNPEYGAKKFEVHATINNIMPSFSSTTSNQFIEKAAHIVKDNLKIIANISIEHLRDEQNSLLQDKEKKNPFSIRLYIQIVRFFTNLFGSFIINKFLISSKALCERMKQVYELSLEALKNENSNKMMLICQMTFLRDEKLSYISFTEDEGKHMIQIINQIRDIPSTNAICEKLMLIKQFLIKFPGPMISTIPEWLPTQVISKIVFSEDVYSTKTGFTAISVLLELLKRCIDHSIGHEYVFQCLHIDSTALYFGDSKDKKLQWSNNTLEQTYDINETHLAAILRDHIDYLVNSKREYKLAMDMWLSFMGLLFNSKGRLAFLASKEGEKWVDINLNCLSVNDPKCRILSLKVWRILIYCVTNNIDFLGEKEAKKISQVLLNPVNVTVNKLEDNSTFMGVKYLLNDFFFSTCGITNKCKPTTNIVLWGNFIFPMLATLLNYSANEDVKFELDTYIGKLLTKAIQNQKNVDKTKSLHPIKVIASEGVSVDDISALQLSQLPYLLETLGSVILLYVLNSKSQNHSQTRMLILEYLEQIPNNQITLSTLCRCISMFYEYYNSIDFIANSPRSLISDMSRVCIKFKDIIFDDNYNVFRNFILSFLMLFQEEEHHVDNLLQELIQNALQANISELKLIEGILSLKKTDCDLFAINWVGKKLLSPSVQEGDFILYSRIVAKISEKQTIVNFLDLADKLGFEVNPTEILRISFWKPSGLVIFLEEYIAKHHVDFADIVSSIIDADRLNNVELFSYVLKHLPENQKSAFIKQHYTKCPLIWNQGVLIDDYDLIDITLDCEICTFIAHHFSFLSTSSKAKLLIIFIEKDMYDLLVQFRYNLIQEFLPTLTIYKKDDIITTVQQHLINYCFAKNSFVLLDCIEPSTLTSRTLEDVIKLLEKSYEDNITFVPAKYIIFIDNLPMDTKINTTEILRVYLVTGDVTQCLFFLTSLINDKKMVPLTRCRNEVFDFFIALDSSNDLSIKAKAVTTFESLINVIFLLRKKVDIGFLSQYIARLPERPSRYLVDLSEKLILNKSFNRSKFRNSSSFNDLHTHVRTWCNQLDNTSGSPRETTPISAAHINDHINKNALSLEKDKDNLTNNTEQQKNIPNSKSQEISKFSSNIADANDLPSNTRESNCDGSQSTEPAGGKMIKIDKGQISADMKNNKIAPRQISSIASEPDTLVNSNIDNKSMIEKGKNGDKTVNNNATTNDFEYRTSEDPIVSVNIPIFNSRVSGLDKLNNQKISDEYVISSHDLELARNGLQNQAQLHDMHEGYKKKSANLLTQHNMRPPFEDVAIPTHKELKIPIFNSLILKSTNQQPMIPNSQRKVQSEVAIRKRPLGNPSTQGQYTDIENERVRDYDDSQSLEDSADIRLHFPNKRARRIVSKLRGFSEYDMGQLSAEEKRNLRIELLDFLMKIEYHTITD
Protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P) (O35789)
Organism: Rattus norvegicus (Rat)
Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
Subcellular location: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:19181664}; Single-pass type II membrane protein. Secreted {ECO:0000269|PubMed:19181664}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:19181664}; Single-pass type II membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19181664}. Secreted {ECO:0000269|PubMed:19181664}.
Interaction partners:
- Carbohydrate sulfotransferase 10
- Beta-1,4-galactosyltransferase
- Beta-1,4-galactosyltransferase
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- Brevican core protein
Sequence:
MPKRRDILAIVLIVLPWTLLITVWHQSSLAPLLAVHKDEGSDPRHEAPPGADPREYCMSDRDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVVEDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRETFPRNSTQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVGWKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPKAANCTKILVWHTRTEKPVLVNEGKKGFTDPSVEI