wanglab/gogpt-training-data huggingface dataset:
Protein: Diacylglycerol lipase-beta (DAGL-beta) (DAGLbeta) (DGL-beta) (EC 3.1.1.116) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) (Q91WC9)
Organism: Mus musculus (Mouse)
Function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (By similarity). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages.
Subcellular location: Cell membrane {ECO:0000305|PubMed:31991095}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Diacylglycerol lipase-alpha
- N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
- Fatty-acid amide hydrolase 1
- Monoglyceride lipase
Sequence:
MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLIVLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNRLLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTLLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLVNDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLYEYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSPDNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSCPGQGGSSVP
Protein: Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) (Transcripts altered in meiosis protein 4) (P0CF96)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:23885124, ECO:0000269|PubMed:24006493}. Note=Localizes to all the MTOCs, including the SPB and interphase and equatorial MTOCs.
Interaction partners:
- Spindle pole body component alp6
- Spindle pole body component alp4
- Gamma-tubulin complex subunit mod21
- Tubulin gamma chain
- Spindle pole body component alp16
- Gamma-tubulin complex component gfh1
- Gamma tubulin complex adapter mto2
- Cytochrome c oxidase assembly factor 3, mitochondrial
- Uncharacterized protein tam6, mitochondrial
- Cx9C motif-containing protein 4, mitochondrial
Sequence:
MSESTKETIEVLYEIGTLLGTELDKTTLSLCISLCENNVHPEAIAQIIREIRMAQEQTVDTEPS
Protein: ADP-ribosylation factor GTPase-activating protein AGD7 (ARF GAP AGD7) (Protein ARF-GAP DOMAIN 7) (AtAGD7) (Protein PDE1 SUPPRESSOR 1) (O80925)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Involved in protein trafficking by controlling ARF1 activity; may participate in COPI vesicle formation at the Golgi complex.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:17307897}.
Interaction partners:
- Probable ADP-ribosylation factor GTPase-activating protein AGD8
- Probable ADP-ribosylation factor GTPase-activating protein AGD9
- ADP-ribosylation factor GTPase-activating protein AGD10
- Coatomer subunit gamma
- ARF guanine-nucleotide exchange factor GNL2
- ADP-ribosylation factor 2-B
- Coatomer subunit delta
- ADP-ribosylation factor
- ARF guanine-nucleotide exchange factor GNL1
- ADP-ribosylation factor 1
Sequence:
MAAARRLRTLQSQPENKVCVDCSQKNPQWASISYGIFMCLECSGKHRGLGVHISFVRSVTMDSWSEIQIKKMDAGGNERLNNFLAQYGISKETDIISKYNSNAASVYRDRIQALAEGRQWRDPPIVKESVGGGLMNKKPPLSQGGGRDSGNGGWDNWDNDDSFRSTDMRRNQSAGDFRSSGGRGAPAKSKSSEDIYSRSQLEASAANKESFFAKRMAENESKPEGLPPSQGGKYVGFGSSPGPAPRSNQQSGGGDVFSVMSEGFGRLSLVAASAANVVQTGTMEFTSKVKEGGLDQTVSETVNVVASKTTEIGQRTWGIMKGVMAIASQKVEEFTKEEASTWNQQNKTEGNGYYQNSGIGNKTANSSFGGSQSSSSGHNNSYRNSNSWDDWGEENNSKKEAAPKVSTSNDDDDGGWAGWDDNDAKDDDFYYQPASDKKSVGHNGKSDTAWTGGGFL
Protein: RNA polymerase II-associated factor 1 homolog (Q1XFY2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSVNQFDSFMEKVQETTPITISGLPFVDDGIYGVQESGQNSSRSSVYSSSKSTVIEVEQSSRQQQVGRPTESPPLPPPPLPLSNPPAKPTPPPPPPKPTIRPPPIPASPPPRPPASEPVGIPLYSEKQHQQQLRPTTAVSPPKPPSFAPPVPPAAALITDTSTTTNALTNAMFEQLKQSSVRYDYVPYKSDHRSFTQNTQPSPLPPAGVGDRRHSVPDDVRHYADETTPPPVLHDVADRYSTVAYMNHEPTHNSTRVYSHSPTRSQVGVRDAHRLSRDDLRVVDAQSSPADSQSEELRRMYSGRSGNSVKPTGDVTARYVYDTANRNYTAYGERQARESYTSFTNNDRKRWSRSSEPRSETYINDPYYSGKDVVSGYGVIETRRSRTSLHSHGSVPELIHSENKYDYQQLTDQQNREMERKSRLDTERRSRRQSEGSRQIYIDRQISPERQRKDQYSGTYTNVNMQDNPQYSIRREVPPPVIPPKPQVVPHVQRVNGGEVYEDERSIYEAYSQIQHQRPQPPIYGGQTLQPIPPPPQPQPIPQQYPPRYDQVPDQSISNHYIIPKSMRGSSSPILVRVQLSSKSPDSVRRQVQPQPQPQPQQQQQYEAYGEADYVSRNLPLGVTEETTTTTTTTRNEEIERKRRKKKEEEDRKKSEEIYVPYNNGEQDYDRYNNYRDAENALIEEEYNTRHLKRTTEHPHRKQPPQKRDNTKDQHRGGKKSSHHHSRETKHRIGWSPSNYRNPRDCFLNLLCFIIAPLVIILILVVIIVFVIIQ
Protein: Lipase-specific foldase (Lif) (Lipase activator protein) (Lipase chaperone) (Lipase helper protein) (Lipase modulator) (Q05490)
Organism: Burkholderia plantarii
Function: Involved in the folding of the extracellular lipase (lip) during its passage through the periplasm.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:8412704}; Single-pass membrane protein {ECO:0000305|PubMed:8412704}; Periplasmic side {ECO:0000305|PubMed:8412704}.
Interaction partners:
Sequence:
MAQADRPARGGLAARPMRGASFALAGLVACAACAAVVLWLRPAAPSPAPAGAVAGGPAAGVPAAASGAAEAAMPLPAALPGALAGSHAPRLPLAAGGRLARTRAVREFFDYCLTAQGELTPAALDALVRREIAAQLDGSPAQAEALGVWRRYRAYFDALAQLPGDGAVLGDKLDPAAMQLALDQRAALADRTLGEWAEPFFGDEQRRQRHDLERIRIANDTTLSPEQKAARLAALDAQLTPDERAQQAALHAQQDAVTKIADLQKAGATPDQMRAQIAQTLGPEAAARAAQMQQDDEAWQTRYQAYAAERDRIAAQGLAPQDRDARIAQLRQQTFTAPGEAIRAASLDRGAGG
Protein: TBC1 domain family member 1 (A0A8I6G5Y5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEAITFTARKHPFPNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSGQCSKKEPGMKQVRLWVSPSGLRCEPDLRKSQPWDPLICSSIFECKPQRVHKLIHNSQDPSYFACLIKEDAAHQQSLCYVFKADDQTKVPEIISSIRQAGKIARQEELRCPSEFDDTFAKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSCGRRIDWDAPTGQPSAPGARPMRKSFSQPGLRSLAFRKEFQDASLRSSTFSSFDNDIENHLIGGHNVVQPTDMEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRECSGGGGAGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQAMIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHSHTGEPKQTLQVAAENIGSELPPSASRFRLDSLKNRAKRSLTESLESILSRGNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDKEALPISESSFKLLGSSDDLSSDSESHIAEESALLSPQQAFRRRANTLSHFPVECPAPPEPAQTSPGVSQRKLMRYHSVSTETPHERNVSYRNALRKKLHSSSSVPNFLKFLAPVDENNTCDFKNTNRDFESKANHLGDTDGTPVKARRHSWRQQIFLRVATPQKACDSPSRYEDYSELGELPPRSPLEPVCEDGPFGPVQEEKKKTSRELRELWKKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKVHSAVGQGVPRHHRGEIWKFLAEQFHLKHPFPSKQQPKDVPYKELLKKLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEYEIGPSLYAAPWFLTVFASQFPLGFVARVFDMIFLQGSEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTISQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANARIQSLEVTVEKLLTSESKLKQAVLTLEMERSALLQMVEELRRQMAQPSTAEPDCTRLEPTGD
Protein: GTP-binding nuclear protein (Q59P43)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363057}.
Interaction partners:
- Ran guanyl-nucleotide exchange factor
- GTPase-activating protein
- Nucleoporin NSP1
- Exportin
- Nucleoporin
- Exportin-T
- Ran GTPase-binding protein
- Importin-95
- Karyopherin
- Nuclear transport factor 2
Sequence:
MAQEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFHTNFGELKFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVASPALAPPEVQVDADLMQKYQQEMEQATALPLPDEDDADL
Protein: Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) (A0A2R8YGD3)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Late endosome {ECO:0000256|ARBA:ARBA00004603}.
Interaction partners:
Sequence:
MASYVDNSFRQAVMKNPPERTPQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPMGKPPLPRGYHTLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGGSGNQLRSFGSGQLDLTSSSSSLGSYTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
Protein: Small ribosomal subunit protein uS2m (37S ribosomal protein MRP4, mitochondrial) (P32902)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein bS21m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS4m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS19m
- Small ribosomal subunit protein mS43
Sequence:
MQRHVFARNFRRLSLLRNPSLTKRFQSSASGAANTPNNNDEVMLLQQKLLYDEIRSELKSLSQVPEDEILPELKKSLEQDKLSDKEQQLEAELSDFFRNYALLNKLFDSKTLDGQSSTTTAAATPTKPYPNLIPSANDKPYSSQELFLRQLNHSMRTAKLGATISKVYYPHKDIFYPPLPENITVESLMSAGVHLGQSTSLWRSSTQSYIYGEYKGIHIIDLNQTLSYLKRAAKVVEGVSESGGIILFLGTRQGQKRGLEEAAKKTHGYYVSTRWIPGTLTNSTEISGIWEKQEIDSNDNPTERALSPNETSKQVKPDLLVVLNPTENRNALLEAIKSRVPTIAIIDTDSEPSLVTYPIPGNDDSLRSVNFLLGVLARAGQRGLQNRLARNNEK
Protein: Staphylococcal nuclease domain-containing protein 1 (Q19328)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR017179}.
Interaction partners:
- Hyaluronan/mRNA-binding protein domain-containing protein
- Piwi-like protein 1
- Protein argonaute-1
- Protein argonaute-1
- Inosine-5'-monophosphate dehydrogenase
- Argonaute protein hrde-1
- Piwi domain-containing protein
- Endoribonuclease dcr-1
- Nuclear RNAi defective-3 protein
- DEAD-box ATP-dependent RNA helicase rde-12
Sequence:
MTDAAAATPTVPPPAASSANPAVRRGLVKSVLSGDAVILQGQPHNGPPPEWTVYLSNVTAPRLGRRPTDSASATPDEPYAWDSREYLRQKLVGQFVTFVRDFTATSGRDHGRIYLGGTSPADAENVAEGAVSAGLLEVRQGKVADEYSTKLLELQEQAKSAGRGKWNSNAGTIRDIRWVIDNPRELVDKYAQKPIDAVIEMVRDGSTVRAFLLPNFEYITLQLSGVRAPSTRNPNAADSRAEAFSEEAKFFAESRLLQRDVQIILESTSNQNFVGSIVHPKGNIAESLLREGYAKCVDWSIGLCTGGAQKLRDAERQAKEKRLRLWKSYQPTSSAYSGDRKAFTGKVVEIVLSDAVVVQKDDGSEVKLHLSSIRLPRESGDDKATGGPGRQFRPLYDIPFMFQAREFLRKRLLGKKVQIQIDYVQPKSENFPEKTCATIKIGDQNIAEGLISRGLSKVVRHRADDENRSSEYDTLLAAEANAEKGKKGLFADKTAEKKDTHRIQEITGDLAKAKQFLPYLQRGGRAEGVVEFLSGGSRLRIYIPKETVLITFLLGGINCPKGARVGPGGVSTGAAEPFADEAAAFTRKLVLQHEVQLEVESTDKNGNFVGYLYVSPDGNTSRAINLSEALVENGLASLHFTAERSGHYNALLSAENKAKKAKKNIWANFTEEQHQEEVEVQQADTSERKQNFRQVAVTDIAPGALRFSAQNIEDGPKIEKMTTEMRQALAEHPPLAGSYTTKRGDLCVAKFSQDGQWYRCKVESVRAGQAEIVYIDYGNRETIEAVKLAQIPAGFANFPAGVREYNLALAKLPNEDYVQLTSDAFAQYLFGHSSVFINSEYKVGTSEYVTVYYDSGNKKVDIGKSLIAEGLALADHRREPRLQTLVNDYNTTEEVARKSRKNIWEYGDFTGNDI
Protein: ABC transporter B family member 4 (ABC transporter ABCB.4) (Q54W24)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MNSLLRCCLIKPINIKNTTSFINKLNPKSIIQKSNNYNNINKNILNKFKDSSSNYFINSNKILEICNNNNNNNKYNVNKRNYSSSSNSGNNNNNNYNNKNNNNNNESFYKKFENSFEIKRIKDILFIIVGTFVIFKIYDNKIGIVFCENEIDKETILNDPYDKIPNEIIVELKDSAKDDNIIEESDEDDGIKKISSFKLFFKTIGNDIWLFGFGIITAFFSSWVGLQIPKVFGVLIDCTKNGDSLQGPAIQAIFILLAQAGLNFLYSTMISVACERYSARLRSTLFGAMLEQEIGFFDQNSTGDLINRLSSDVQLVRSALKHSVSLGVKSFGQIVGGVISLILISPKLSLGMMTILPTMVSVGTFYAGWLKSLSVRSQRAQAQSTIVAEEAIGNIRTVQAFSNQHYESERFIEKNQHSLALSTESGVQIGIFQGVTSLALNSVSLLVYWYGGTLVSRGEMTGGQLTSFIIHTMNMQSSFSQLSILFTQIMSAMGGMQRITELINRVPLINSNQGFKLRELKGEIKFINVDFKYPTRPHVHVLNGLNLTLKPGQVVALAGSSGGGKSTIAGLLERFYDISNGDITIDGYSIKQLNAKWLRSRIGIVSQEPSLFATTILENLRYGNPNATEDEIIEAAKLANAHQFISNFPKGYETIVGERGVQLSGGQKQRIAIARAILKNPQIIILDEATSALDSQSELLVQTALDNLMKGRTTLVIAHRLSTVQNADLIGVLSHGKIAEFGNHNELMNHKGLYYKLVQRQLSQQQQ
Protein: ABC transporter B family member 7 (ABC transporter ABCB.7) (AtABCB7) (Multidrug resistance protein 7) (P-glycoprotein 7) (Q9FHF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MAEKAKKKKNGGGGNQRIAFYKLFTFADRYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVFGFSDHDHVFKEVSKVAVKFLYLAAYAGVVSFLQVSCWMVTGERQSTRIRRLYLKTILRQDIGFFDTETNTGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLALLPCVPLIVGTGGAMTYIMSKKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKLEIAYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGARQIIEKGYTGGQVMNVITSILTGGMALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRDVYFRYPARPDVQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQVKWIRSKIGLVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKLPQGLETMVGEHGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTTVVVAHRLTTIRTADMIAVVQQGKVIEKGTHDEMIKDPEGTYSQLVRLQEGSKKEEAIDKEPEKCEMSLEIESSDSQNGIHSGTLTSPSGLPGVISLDQTEEFHENISSTKTQTVKKGKEVSLRRLAHLNKPEISVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFEPSNKLKNDSLFWALIFVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVIGARLSTDASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYYQIKFITGFGAKARGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDEPKQQGFKLGLVSGLCYGGSYLALYVIESVCFLGGSWLIQNRRATFGEFFQVFFALTLTAVGVTQTSTMAPDINKAKDSAASIFDILDSKPKIDSSSEKGTILPIVHGDIELQHVSFRYPMRPDIQIFSDLCLTISSGQTVALVGESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKLSWLREQMGLVSQEPVLFNETIGSNIAYGKIGGATEEEIITAAKAANVHNFISSLPQGYETSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDQVMVNRTTVVVAHLLTTIKDADMIAVVKNGVIAESGRHETLMEISGGAYASLVAFNMSAN
Protein: WD repeat domain 36 (A0A0A0MTB8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTCQTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALFLKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL
Protein: DNA polymerase type-X family protein pol4 (EC 2.7.7.7) (Q09693)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Repair polymerase. Involved in gap-filling in DNA non-homologous end joining (NHEJ) required for double-strand break repair. Can incorporate a ribonucleotide (rNTP) into a primer DNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exodeoxyribonuclease 1
- DNA polymerase zeta catalytic subunit
- Endonuclease III homolog lyase)
- ATP-dependent DNA helicase II subunit 1
- DNA repair protein rev1
- DNA repair and recombination protein rad22
- Flap endonuclease 1
- DNA ligase 3
- ATP-dependent DNA helicase II subunit 2
- DNA polymerase delta catalytic subunit
Sequence:
MKILASSTNYVLHNRLSNSQYEDARSKIVNFGGEFTNDAAKADYIFVNYSQINRVRRELRTIGTPLETCVSCKLIVKIDWLNEPKESLTPGNPYVIWHRKPEMKVGSPYTPSTRPASHTEAPNDFENHETPNTENNNEVKSIDNVDQEGSVYPTTKEYPYVLEIPRYACQRKTPLKCVNQAFVNALSVLKTCREVNGESVRTRAYGMAIATIKAFPLPIDSAEQLEKMPGCGPKIVHLWKEFASTGTLKEAEEFQKDPASKILLLFYNIFGVGASHAAEWYQKGWRTIEQVRKHKDSFTKQIKVGLEFYEDFCKTVTIEEATEIYETIVSRMPDGIKIQSCLVGGFRRGKPVGADVDMVLSPSHTHSTKHLVDVLLRILDEEFQFRLISVQEHSCGGKKGYVMLAVILSNSSKINRRVDIIVVPPAYIGSAVLGWSGGIFFLRDLKLYANSHLGLSYDSFEIINLKTGKDICPDEFNEWKDPVEAEKDIFRYFSLEYIEPKFRNTG
Protein: trypsin (EC 3.4.21.4) (Q8IPY7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Peptidase S1 domain-containing protein
- trypsin
- Peptidase S1 domain-containing protein
- trypsin
- Uncharacterized protein
- trypsin
- Uncharacterized protein
Sequence:
MCLRLLLSILVSIAGLACAARIPGPEERIVGGSYIPIEYVPWQVSVQNNSLHCCGGVIYSDRAILTAAHCLSNVTVTDLSVRAGSSYWSKGGQVLKVLKTIAHPKYVPKLYNPYDIAVLILEAPLRLGGTVKKIPLAEQTPVAGTIVLTSGWGYTRENSSFLWPILQGVHVAILNRTDCLKAYKHVNITIDMICADGQRWDTCQGDSGGPLIETTKGGHRQLIGMVSWGDGCGTNPGVYEDIAFFHNWIKYTVKKNIYKSIVKI
Protein: WD repeat-containing protein 82 (Q6UXN9)
Organism: Homo sapiens (Human)
Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome.
Subcellular location: Nucleus {ECO:0000269|PubMed:16253997, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20516061}. Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with chromatin (PubMed:20516061). Recruited at sites of high RNA polymerase II occupancy (By similarity). {ECO:0000250|UniProtKB:Q8BFQ4, ECO:0000269|PubMed:20516061}.
Interaction partners:
- CXXC-type zinc finger protein 1
- Histone-lysine N-methyltransferase SETD1A
- WD repeat-containing protein 5
- Histone-lysine N-methyltransferase SETD1B
- Retinoblastoma-binding protein 5
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Cleavage and polyadenylation specificity factor subunit 3
- pre-mRNA 3' end processing protein WDR33
Sequence:
MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD
Protein: Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (mDkk-2) (Q9QYZ8)
Organism: Mus musculus (Mouse)
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Subcellular location: Secreted.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- Kremen protein 1
- Dickkopf-related protein 1
- Dickkopf-related protein 4
- Kremen protein 2
- Protein Wnt-2
- Dickkopf-related protein 3
- Protein Wnt-5a
- Protein Wnt-6
Sequence:
MAALMRVKDSSRCLLLLAAVLMVESSQLGSSRAKLNSIKSSLGGETPAQSANRSAGMNQGLAFGGSKKGKSLGQAYPCSSDKECEVGRYCHSPHQGSSACMLCRRKKKRCHRDGMCCPGTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHSKMPHIKGHEGDPCLRSSDCIDGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
Protein: Homeobox protein unc-42 (Uncoordinated protein 42) (L8E946)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Required for initial outgrowth and pathfinding of axon growth cones along the ventral nerve cord (VNC). Involved in specifying neuron identity, in concert with nuclear hormone receptor family member fax-1, or with transcription factors unc-3, cfi-1, or hlh-34, perhaps acting via positive feedforward loops. Establishes electrically- and chemically-interconnected neuron circuits, acting by modulating the expression of neurotransmitter pathway genes, neurotransmitter receptors, neuropeptides, and neuropeptide receptors. Required for cholinergic and glutamatergic synaptic communication. Plays a role in locomotion and mechanosensory response, perhaps via regulation of chemosensory receptor expression, and is required for expression of glutamate receptors, including glr-1, glr-4 and glr-5.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682}.
Interaction partners:
- Transcription factor unc-3
- Transcription factor unc-86
- Nuclear hormone receptor family member fax-1
- AT-rich interactive domain-containing protein cfi-1
- Thioredoxin-related transmembrane protein 1
Sequence:
MSDNLLNGANGASTVSQFQEKVKDLGVSLHDFTAYYPSSLDTVSASLRPISDPSSDGAFKKIKTEGLGGSVFGSSIAGVTNTPARLCSLERPESERLNSRRRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQLNKAINPPHSFLSNPANTLMRQGMYPAALNRDGFWYQSYQRPMPYPTASPSYSNSFTNPIANFGHSITSFQADDEFYQKSLALRMTTTPSAATAATSLANINYQQTQPSEASTNPPSI