Protein: E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) (P97868)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation. Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication.
Subcellular location: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
Interaction partners:
- pre-mRNA 3' end processing protein WDR33
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 3
- Symplekin
- WD repeat-containing protein 82
- E3 ubiquitin-protein ligase E3D
- Pre-mRNA cleavage complex 2 protein Pcf11
- Cleavage and polyadenylation specificity factor subunit 4
- Poly
Sequence:
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPVPPPRPLMQRNLQPLMRSPISRQQDPLMIPVTSSSAHSAPSISSLTSNPSALAPSVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKLLPAAALTSEHSKGASSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINAARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANISTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPTKRNVPQGETEREYFNRYREVPPPYDIKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAVGAQPRPSANREDFSPERLLPLNIRNSPFTRGRREDYAAGQSHRNRNLGGNYPEKLSTRDSHNAKDNPKSKEKESENVPGDGKGNKHKKHRKRRKGEESESFLNPELLETSRKCRESSGIDETKTDTLFVLPSRDDATPVRDEPMDAESITFKSVSDKDKREKDKPKVKSDKTKRKSDGSATAKKDNVLKPSKGPQEKVDGDREKSPRSEPPLKKAKEEATKIDSVKPSSSSQKDEKVTGTPRKAHSKSAKEHQEAKPAKDEKVKKDCSKDIKSEKPASKDEKAKKPEKNKLLDSKGEKRKRKTEEKSVDKDFESSSMKISKVEGTEIVKPSPKRKMEGDVEKLERTPEKDKIASSTTPAKKIKLNRETGKKIGNAENASTTKEPSEKLESTSSKIKQEKVKGKAKRKVAGSEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKTTQPIQSVGKPSSIIKNVTTKPSATAKYTEKESEQPEKLQKLPKEASHELMQHELRSSKGSASSEKGRAKDREHSGSEKDNPDKRKSGAQPDKESTVDRLSEQGHFKTLSQSSKETRTSEKHESVRGSSNKDFTPGRDKKVDYDSRDYSSSKRRDERGELARRKDSPPRGKESLSGQKSKLREERDLPKKGAESKKSNSSPPRDKKPHDHKAPYETKRPCEETKPVDKNSGKEREKHAAEARNGKESSGGKLPCIPNPPDPPMEKELAAGQVEKSAVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEEAVASISKDLKEKTTEKAKESLTVATASQPGADRSQSQSSPSVSPSRSHSPSGSQTRSHSSSASSAGSQDSKKKKKKKEKKKHKKHKKHKKHKKHAGADGDVEKSQKHKHKKKKAKKNKDKEKEKDDQKVRSVTV