wanglab/gogpt-training-data huggingface dataset:
Protein: P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1) (O15547)
Organism: Homo sapiens (Human)
Function: Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P51579}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P51579}. Nucleus {ECO:0000250|UniProtKB:O54803}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54803}; Multi-pass membrane protein {ECO:0000255}. Note=Heteromerization of P2RX6 subunits with either P2RX2 or P2RX4 subunits guides the P2RX6 subunit to the plasma membrane (By similarity). Monomers remain anchored to the endoplasmic reticulum (ER) membrane by the hydrophobic N-terminal end (By similarity). Mainly expressed in the cell body of the hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000250|UniProtKB:P51579}.
Interaction partners:
- P2X purinoceptor 1
- P2X purinoceptor 3
- P2X purinoceptor 4
- P2X purinoceptor 2
- P2X purinoceptor 5
- P2X purinoceptor 7
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
Sequence:
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL
Protein: RNA-binding protein Rsf1 (RNA-binding protein Rox21) (Q24491)
Organism: Drosophila melanogaster (Fruit fly)
Function: May control important aspects of development.
Subcellular location: Nucleus.
Interaction partners:
- LD40489p
- Transformer-2 sex-determining protein
- LD32469p
- RNA-binding protein 1
- Serine/arginine-rich splicing factor x16
- Rbp1-like, isoform B
- FI21236p1
- FI04408p
Sequence:
MGDQRGTRVYVGNLTDKVKKDDLEGEFTKYGKLNSVWIAFNPPGFAFVEFEHRDDAEKACDILNGSELLGSQLRVEISKGRPRQGRRGGPMDRGGRRGDFGRHSITSGGSGGGGFRQRGSSGSSSRHTERGYSSGRSGASSYNGREGGGSGFNRREVYGGGRDSSRYSSGSSASYGRTGGQSAGRFRSRSPVGNHRF
Protein: NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Q6NPS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (By similarity). Catalyzes the NADP-dependent reduction of cytochrome c, but not cytochrome P450 in vitro. Required for embryo development.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:20406405}. Nucleus {ECO:0000269|PubMed:20406405}.
Interaction partners:
- Anamorsin homolog
- At2g31490
- Cytosolic Fe-S cluster assembly factor NBP35
- Protein NAR1
- Assimilatory sulfite reductase
- MMS19 nucleotide excision repair protein homolog
- Carotene epsilon-monooxygenase, chloroplastic
- Ferredoxin--nitrite reductase, chloroplastic
- Protein AE7
- FAD-linked sulfhydryl oxidase ERV1
Sequence:
MGEKQRKLLVLYASQTGNALDAAERIGREAERRGLPASVVSTDEFDTSSLPHHEEAVVFVVSTTGQGDSPDSFKAFWRFLLQRNLGNYWLQQVRYAVFGLGDSGYQKYNFVAKKLDKRLSDLGATTIIEKGLGDDQHPSGYEGTLDPWMLSLWRTLYQINPKYFPKGPDVKIPQDEVIDKPKYRILFHKQEKLEPKLLSDSDIIQRARGMSPGKLFKDKSKPDCFLKMTRNEVLTKAESTKDVRHFEFQFVSSTIEYEVGDVVELLPSQNSSVVDAFIERCGLDPESFITVGPRETENSSFSEEMITQIPIKLKTFVELTMDVTSASPRRYFFEIMSFYATAEHEKERLQYFASPEGRDDLYNYNQKERRSILEVLEDFPSVQIPFDWLVQLVPPLKPRAFSISSSPLAHPAAVHLTVSIVSWITPYKRTRKGLCSSWLASLAPEQEVNIPVWFHKGSLPAPSQSLPLILVGPGTGCAPFRGFIAERAVQAQSSPVAPVMFFFGCRNKDTDFLYRDFWESHAREGGMLSEGKGGGFYTAFSRDQPKKVYVQHKIREMSKRVWDLLCDGAAVYVAGSSTKMPCDVMSAFEDIVSEETGGGSKEVASRWLKALEKTGRYNVEAWS
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog) (P62875)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:9852112}. Nucleus, nucleolus {ECO:0000305|PubMed:34887565, ECO:0000305|PubMed:36271492}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA43
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase III subunit RPC8
Sequence:
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK
Protein: Probable LRR receptor-like serine/threonine-protein kinase At2g24230 (EC 2.7.11.1) (C0LGK9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Cyclase-associated protein 1
- Protein SGT1 homolog B
- Protein SGT1 homolog A
Sequence:
MGLGLGFWGYALFLSLFLKQSHCQEPNTDGFFVSEFYKQMGLSSSQAYNFSAPFCSWQGLFCDSKNEHVIMLIASGMSLSGQIPDNTIGKLSKLQSLDLSNNKISALPSDFWSLNTLKNLNLSFNKISGSFSSNVGNFGQLELLDISYNNFSGAIPEAVDSLVSLRVLKLDHNGFQMSIPRGLLGCQSLVSIDLSSNQLEGSLPDGFGSAFPKLETLSLAGNKIHGRDTDFADMKSISFLNISGNQFDGSVTGVFKETLEVADLSKNRFQGHISSQVDSNWFSLVYLDLSENELSGVIKNLTLLKKLKHLNLAWNRFNRGMFPRIEMLSGLEYLNLSNTNLSGHIPREISKLSDLSTLDVSGNHLAGHIPILSIKNLVAIDVSRNNLTGEIPMSILEKLPWMERFNFSFNNLTFCSGKFSAETLNRSFFGSTNSCPIAANPALFKRKRSVTGGLKLALAVTLSTMCLLIGALIFVAFGCRRKTKSGEAKDLSVKEEQSISGPFSFQTDSTTWVADVKQANAVPVVIFEKPLLNITFSDLLSATSNFDRDTLLADGKFGPVYRGFLPGGIHVAVKVLVHGSTLSDQEAARELEFLGRIKHPNLVPLTGYCIAGDQRIAIYEYMENGNLQNLLHDLPFGVQTTDDWTTDTWEEETDNGTQNIGTEGPVATWRFRHKIALGTARALAFLHHGCSPPIIHRDVKASSVYLDQNWEPRLSDFGLAKVFGNGLDDEIIHGSPGYLPPEFLQPEHELPTPKSDVYCFGVVLFELMTGKKPIEDDYLDEKDTNLVSWVRSLVRKNQASKAIDPKIQETGSEEQMEEALKIGYLCTADLPSKRPSMQQVVGLLKDIEPKSNQ
Protein: Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3) (O43820)
Organism: Homo sapiens (Human)
Function: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8VEI3}. Cell membrane {ECO:0000250|UniProtKB:Q8VEI3}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8VEI3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VEI3}. Early endosome {ECO:0000250|UniProtKB:Q8VEI3}. Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1. Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail. {ECO:0000250|UniProtKB:Q8VEI3}.
Interaction partners:
- Alpha-L-iduronidase
- Beta-glucuronidase
- Arylsulfatase B
- C-Jun-amino-terminal kinase-interacting protein 4
Sequence:
MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGFAGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQRCHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
Protein: Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)] (P07480)
Organism: Sus scrofa (Pig)
Function: Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Subcellular location: Secreted {ECO:0000269|PubMed:1381832, ECO:0000269|PubMed:6197320}.
Interaction partners:
- Galanin receptor type 3
- Galanin receptor 1
- Galanin receptor type 2
- Somatostatin
- Pro-neuropeptide Y
- Cholecystokinin
- Dopamine beta-hydroxylase
- VIP peptides
- G_PROTEIN_RECEP_F1_2 domain-containing protein.
- Tyrosine 3-monooxygenase
Sequence:
MPRGCALLLASLLLASALSATLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKYGLAGKRELEPEDEARPGGFDRLQSEDKAIRTIMEFLAFLHLKEAGALGRLPGLPSAASSEDAGQS
Protein: DnaJ homolog subfamily C member 8 (Splicing protein spf31) (O75937)
Organism: Homo sapiens (Human)
Function: Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:27133716}.
Interaction partners:
- ATP-dependent RNA helicase A
- Pre-mRNA-processing factor 40 homolog A
- Serrate RNA effector molecule homolog
- Nuclear inhibitor of protein phosphatase 1
- RNA-binding protein 39
- Serine/arginine repetitive matrix protein 2
- Splicing factor 3A subunit 2
- 17S U2 SnRNP complex component HTATSF1
- RNA-binding protein 25
- Probable ATP-dependent RNA helicase DDX5
Sequence:
MAASGESGTSGGGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKKEGKPTIVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRVDSWRNFQANTKGKKEKKNRTFLRPPKVKMEQRE
Protein: Interleukin 6 cytokine family signal transduce (Interleukin-6 receptor subunit beta isoform 2 precursor) (F1RCZ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDTSHHWLLVLMLLHYAKGSNSSCVLKILPDSKTKIPVELERNFTATCHLQGGSEFTSNDIKWSFSNKETTDILSKTFYHKINETSVSVTVNLSKNMGHMLMCEASRESLTYMGKCAYGIYLDAGYPPMKPKNLTCIALQRKKDISPDLNCYWEPGLRDPLLATNYTLYAQVGQDLYNSTCKQSLARSCTVNLSTYPVHMTLKVWVEVKNSLGSERSDEHEYDSLSLVKPNPPNVEVKVEEDFPTSFVVKWEYDIEDTTMRFSSAIRYCQVGSSDWKKVPENYTNVHITSYRLQSLEPYTEYVVQMRSIGEHYTIWSEWSSNVTVRTPEAKPASPPDLWRIIQHTPGKRNVTLMWKPPVKANGKMCNYSLIISQDNQAFESHVIKADQLNQRYSLEVPPEENASIEITAFNSAGGSPKTILFIPRSNDEFLGVASMRWWVHDGKLHVEWGPLKQHPPHGIHISEYLLEWVNEKDVQPQWQRVPKNVNTTILNGNLAKYKQYNISVYPIYKFYYDGRWHFQAGTPVTKPAYVQQGAPEKGPTVTDTISKKNSVTLIWEEIPLDHRYGFIQNYTIFYRTGNAEWQSVLVAANIHSYVLTDLVSERDYVVHIMASTEAGSKNGTDFNFKTMKFADGEVEMIVVLVCLGFLFLSVFTIMLCLRKREVIKKLLWPQVPDPSDSSIAHWSPDFPVKTEMPKEDVSVVEVDVFDGKSLCEEDKVVLPLKKDKYLSEEHSSGIGGSSCMSSPRHSVSDSDEGDSGQTTASTVQYSSVVASGYKGQTPNHQPPTFARSESTQPLLDCEEHPENHPGERNSYFRRGRELEPQSIDEPVFSAVQEEEASPVVDDAPALSYMPQQSGYRPQ
Protein: Red-sensitive opsin (Iodopsin) (Red cone photoreceptor pigment) (P22329)
Organism: Gallus gallus (Chicken)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- G protein subunit alpha transducin 2
- G protein subunit beta 3
- Guanine nucleotide-binding protein subunit gamma
- Proline rich 11.
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MAAWEAAFAARRRHEEEDTTRDSVFTYTNSNNTRGPFEGPNYHIAPRWVYNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDGSEVSTSRTEVSSVSNSSVSPA
Protein: Probable manganese-transporting ATPase PDR2 (EC 7.2.2.-) (Protein MALE GAMETOGENESIS IMPAIRED ANTHERS) (Protein PHOSPHATE DEFICIENCY RESPONSE 2) (Q9LT02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity). Plays an important role in pollen and root development through its impact on protein secretion and transport processes. Functions together with LPR1 and LPR2 in a common pathway that adjusts root meristem activity to phosphate availability. Under phosphate limitation, restricts SHR movement in root meristem and is required for maintaining SCR expression in the root meristem stem-cell niche as well as for proximal meristem activity. Can complement the yeast spf1 mutant.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16291648, ECO:0000269|PubMed:19666499}; Multi-pass membrane protein {ECO:0000269|PubMed:16291648, ECO:0000269|PubMed:19666499}. Note=Found in secretory vesicles of the tapetum and developing pollen grains.
Interaction partners:
- Multicopper oxidase LPR2
- Aluminum-activated malate transporter 1
- Multicopper oxidase LPR1
- Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
- Peroxidase 10
- CLAVATA3/ESR
- Protein GOLVEN 5
- Probable E3 ubiquitin-protein ligase LUL4
- Protein PHOSPHATE STARVATION RESPONSE 1
Sequence:
MSSFRVGGKVVEKVDLCRKKQLVWRLDVWPFAILYTVWLTTIVPSIDFSDACIALGGLSAFHILVLLFTTWSVDFKCFVQFSKVNSIDQADACKVTPAKFSGSKEVVPLHFRSQMTDSASSGDMEEIFFDFRKQRFIYSKELGAFSKLPYPTKETFGHYLKCTGHGTEAKIATATEKWGRNVFDYPQPTFQKLMKENCMEPFFVFQVFCVGLWCLDEFWYYSVFTLFMLFMFESTMAKSRLKTLTDLRSVRVDSQTVMVYRSGKWVKLLGTDLLPGDVVSIGRPSTQTGGEDKTVPADMLLLVGSAIVNEAILTGESTPQWKVPIVGQRSDEKLSIKRNKNHVLFGGTKILQHSPDKSFSLKTPDGGCLAVVLRTGFETSQGKLMRTILFSTERVTANSWESGLFILFLVVFAVIAAGYVLVKGLEDPTRSKYKLLLGCSLIITSVIPPELPMELSIAVNTSLLALVRRGIFCTEPFRIPFAGKVDLCCFDKTGTLTSDDMEFRGVGGLSNCEEAETDMSKVPVRTLEILASCHALVFVENKLVGDPLEKAALKGIDWSYKADEKALPRRGNGNSVQIMQRYHFASHLKRMSVIVRIQEEYLAFVKGAPETIQERLVDVPAQYIETYKRYTRQGSRVLALAYKRLPDMMVSEARDMDRDAVESDLTFAGFAVFNCPIRPDSAPVLLELKNSSHDLVMITGDQALTACHVAGQVHIVSNPVLILGRSGSGNEYKWVSPDEKEIIPYSEKEIETLAETHDLCIGGDSIEMLQATSAVLRVIPFVKVFARVAPQQKELILTTFKAVGRGTLMCGDGTNDVGALKQAHVGVALLNNKLPLSPSDSSKDDKSKSKKSKLPLEPASKTITQNGEGSSKGKIPPQNRHLTAAELQRQKLKKIMDDLNNDEGDGRSAPLVKLGDASMASPFTAKHASVAPVTDIIRQGRSTLVTTLQMFKILGLNCLATAYVLSVMYLDGVKLGDVQATISGVLTAAFFLFISHARPLQTLSAERPHPSVFSVYLFLSLIGQFAVHLTFLVYSVKEAEKHMPEECIEPDASFHPNLVNTVSYMVSMMLQVATFAVNYMGHPFNQSIRENKPFFYALIAGAGFFTVIASDLFRDLNDSLKLVPLPQGLRDKLLIWASLMFIICYSWERLLRWAFPGKISSWKHKQRAVTANLEKKKKV
Protein: UDP-glycosyltransferase 79B2 (EC 2.4.1.-) (Q9T080)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- KRR1 family protein
Sequence:
MGGLKFHVLMYPWFATGHMTPFLFLANKLAEKGHTVTFLIPKKALKQLENLNLFPHNIVFRSVTVPHVDGLPVGTETVSEIPVTSADLLMSAMDLTRDQVEGVVRAVEPDLIFFDFAHWIPEVARDFGLKTVKYVVVSASTIASMLVPGGELGVPPPGYPSSKVLLRKQDAYTMKNLESTNTINVGPNLLERVTTSLMNSDVIAIRTAREIEGNFCDYIEKHCRKKVLLTGPVFPEPDKTRELEERWVKWLSGYEPDSVVFCALGSQVILEKDQFQELCLGMELTGSPFLVAVKPPRGSSTIQEALPEGFEERVKGRGVVWGEWVQQPLLLSHPSVGCFVSHCGFGSMWESLLSDCQIVLVPQLGDQVLNTRLLSDELKVSVEVAREETGWFSKESLFDAINSVMKRDSEIGNLVKKNHTKWRETLTSPGLVTGYVDNFIESLQDLVSGTNHVSK
Protein: Transcription factor bHLH128 (Basic helix-loop-helix protein 128) (AtbHLH128) (bHLH 128) (Transcription factor EN 74) (bHLH transcription factor bHLH128) (Q8H102)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- At5g05830
Sequence:
MYQSSSSTSSSSQRSSLPGGGGLIRYGSAPGSFLNSVVDEVIGGGSSNARDFTGYQPSSDNFIGNFFTGAADSSSLRSDSTTCGVNNSSDGQKQLGNNNNNNSNKDIFLDRSYGGFNEISQQHKSNDIGGGNSSGSYSLARQRSSPADFFTYLASDKNNFSLNQPTSDYSPQGGSNGGRGHSRLKSQLSFTNHDSLARINEVNETPVHDGSGHSFSAASFGAATTDSWDDGSGSIGFTVTRPSKRSKDMDSGLFSQYSLPSDTSMNYMDNFMQLPEDSVPCKIRAKRGCATHPRSIAERERRTRISGKLKKLQDLVPNMDKQTSYSDMLDLAVQHIKGLQHQLQNLKKDQENCTCGCSEKPS
Protein: Cadherin-5 (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) (O02840)
Organism: Sus scrofa (Pig)
Function: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity).
Subcellular location: Cell junction, adherens junction {ECO:0000250|UniProtKB:Q68SP4}. Cell membrane {ECO:0000250|UniProtKB:P33151}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P55284}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000250|UniProtKB:P33151}.
Interaction partners:
- Platelet endothelial cell adhesion molecule
- Catenin beta 1.
- Catenin delta 1
- Vascular endothelial growth factor receptor 2
- Catenin alpha-1
- von Willebrand factor
- Claudin
- Junction plakoglobin
- Partitioning defective 3 homolog
- CD34 molecule
Sequence:
MQVLVMLLAAAGTYLGLLTAPTAASNPGRQDTPSTLPLHRRQKRDWIWNQMHIDEEKNGSLPHYVGKIKSSVNHKNTKYQLKGESAGKVFRVDENTGDVYAFERLDREKIPEYQLVALVVDKNTEKNLESPSSFTIKVHDINDNWPVFTQLVFNASVPEMSVIGTSVIQLTAVDADDPTVADHASVIYRLKEGEEHFRIRGPGLIETASKNLDRETVPMYKIVVETQDAQGLRGDSGTATVFITLQDVNDNFPVFTQTRYTFSVPEDIRVGSPLGSLFVKDPDEPQNRKTKYSIVQGEYRDTFTIEPDPTRNEGIIKPMKPLDYERIQQYSFTIEATDPTIDLRYLSGTSTKNIARVIINVTDVDEPPNFKQPFYHFQLRENEKKPWIGSVLAVDPDAAQRSIGYSIRRTSDKGQFFGINKHGNIYNVKELDREVYPWYNLTVEAKELDSRGTPTGKESIVQVHIEVLDENDNAPEFAKPYEAKVCEDAPQGKLVVQISAIDKDVTPRDVKFKFSLSTEDSNFTLTDNHDNTANITVKHGYFDRERAKVHHLPILISDNGRPSLTGTSTLHVTVCKCNERGEFTLCEEMGAQVGVSIQALVAIFLCILTIAVISLLVYLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRHGGAKPPRPALDARPSLYAQVQKPPRHAPGAHAPGEMAAMIEVKKDEADHDGGGPPYDTLHIFGYEGAESIAESLSSLGTDSSDSDIDYDFLNDWGPRFKMLAELYGSDPREELLY
Protein: Uncharacterized protein C3B8.11 (O59719)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor rrn11
- RNA polymerase I-specific transcription initiation factor rrn7
- RNA polymerase I-specific transcription initiation factor rrn3
- TATA-box-binding protein
- Upstream activation factor subunit spp27
- Copper-transporting ATPase ccc2
- DNA-directed RNA polymerase I subunit rpa43
- SAGA complex/transcription factor TFIID complex subunit Taf12
- RNA polymerase I-specific transcription initiation factor RRN9 homolog
- RNA polymerase I-specific transcription initiation factor rrn5
Sequence:
MSTWPIDAISKKPSVSLDYGIIGACQLLNPSGYHRAEKVENNEWTFARYDSYTGVELVDLDKRWDILSLNPNYKLPKLTELPAEATNSTRKATSSSFGLSVCRYVPRNLFSTLAKESQLASSAESIYNPHILNTFCLGKTAPSDKNRYTTTECLACSKISNETAENLLFLCLSSPWIFRASPTLQNTATFEEFPFYLNVSAFEFAEDPIWKFSQPVRQLVFSNGEPSLLFALSSCELVIFQVTYDLMFLDEPNTPGCLSAIPLRFLYADDVYNSDSFANVSVHPTDNSFFLTTSSSGRWTIWQFLDDGYRECFGSSFKESLQQALCSAPTSSIAYHEEEINPDNTIYRAKWEEYFGGVILHNAFFILHVSLGEVPDFHLLFHCSSDVRILQVVNESMPIKSEFFILTTESVLWMDIQHPQKPLLEWKHNRKLDPTLKITVTATFSQNIYVSVYSQMNGVVQQIHFSKDRALPVSGSHPFLLLNEVQVPIRSLIIQPCYFFESSEFDRQGPFDSPFWSAIIDKADGSLSLHILCEKSSLKIYNLEELTGSSQVAMKFKTITPSVNTSEDDSANDQEIISTPNSDFQQLSLSRLYHVLCSNRNKKNTITLDEFASKVPDFVEAFDSINHDVIITLSELYDGFPLKGTFTNVAEIISHLEGTELSFYFPYMFGINYNNASFFYTSVDSIASLIHRRWESNTDKSVEIPCFQSSQRRSIKNVIHYLFLSSIGVSREKIFDPSLSRKEIDSTDLLTFIKPFYDTEGLELNEDVRNILENWEIGKISSTYVIGDSAVETEDPSSSQFSDFYISQQQSSVLPSSQIATVFSQEDVPNFSSLYSESSSQTIPIMSQVVSGKYGSRPSKKKKKRSGF
Protein: Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) (Q8TCB0)
Organism: Homo sapiens (Human)
Function: This protein aggregates to form microtubular structures.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Interferon-induced protein 44-like
- Interferon-induced protein with tetratricopeptide repeats 3
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Antiviral innate immune response effector IFIT1
- XIAP-associated factor 1
- Interferon-induced GTP-binding protein Mx1
- Ubiquitin-like protein ISG15
- Interferon-induced protein with tetratricopeptide repeats 2
- 2'-5'-oligoadenylate synthase 1
- Interferon alpha-inducible protein 6
Sequence:
MAVTTRLTWLHEKILQNHFGGKRLSLLYKGSVHGFRNGVLLDRCCNQGPTLTVIYSEDHIIGAYAEESYQEGKYASIILFALQDTKISEWKLGLCTPETLFCCDVTKYNSPTNFQIDGRNRKVIMDLKTMENLGLAQNCTISIQDYEVFRCEDSLDERKIKGVIELRKSLLSALRTYEPYGSLVQQIRILLLGPIGAGKSSFFNSVRSVFQGHVTHQALVGTNTTGISEKYRTYSIRDGKDGKYLPFILCDSLGLSEKEGGLCRDDIFYILNGNIRDRYQFNPMESIKLNHHDYIDSPSLKDRIHCVAFVFDASSIQYFSSQMIVKIKRIRRELVNAGVVHVALLTHVDSMDLITKGDLIEIERCEPVRSKLEEVQRKLGFALSDISVVSNYSSEWELDPVKDVLILSALRRMLWAADDFLEDLPFEQIGNLREEIINCAQGKK
Protein: Large ribosomal subunit protein uL23cz/uL23cy (50S ribosomal protein L23, chloroplastic) (Q6ENC8)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: Binds to 23S rRNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein
- FHA domain-containing protein
- FHA domain-containing protein
- Histone acetyltransferase
- Histone-lysine N-methyltransferase SUVR5
Sequence:
MDGIKYAVFTEKSLRLLGKNQYTFNVESGFTKTEIKHWVELFFGVKVVAVNSHRLPGKGRRMGPILGHTMHYRRMIITLQPGYSIPLLDREKN
Protein: Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851) (Q8NCP5)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MGVKTFTHSSSSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILWNTPNSQPEKGLDAGQENNSNCNFTSRDGSISPVSSECSVVERTIPVCRESRRKRKSYIVMSPESPVKCGTQTSSPQVLNSSASYSENRNQPVDSSLAFPWTFPFGIDRRIQPEKVKQAENTRTLELPGPSETGRRMADYVTCESTKTTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEQVQEDLLISPQSSSIGSVDEGVSEGLPTLQSTSSTNAPPDDDDRLENVQYPYQLYIAPSTSSTERPSPNGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDRCGKKFTRAYSLKMHRLKHEGKRCFRCQICSATFTSFGEYKHHMRVSRHIIRKPRIYECKTCGAMLTNSGNLIVHLRSLNHEASELANYFQSSDFLVPDYLNQEQEETLVQYDLGEHGFESNSSVQMPVISQYHSKGKEP