Protein: Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Vlc27a1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-) (Q60714)
Organism: Mus musculus (Mouse)
Function: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (Probable). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10471110, ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:11470793, ECO:0000269|PubMed:11970897, ECO:0000269|PubMed:24858472, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:7954810, ECO:0000269|PubMed:9786857}; Single-pass membrane protein {ECO:0000269|PubMed:11470793, ECO:0000269|PubMed:7954810}. Mitochondrion outer membrane {ECO:0000269|PubMed:24858472}. Endomembrane system {ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:15897321}; Single-pass membrane protein {ECO:0000269|PubMed:11470793, ECO:0000269|PubMed:7954810}. Cytoplasm {ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:15897321}. Note=Plasma membrane and intracellular membranes, at least in adipocytes (PubMed:10593920, PubMed:11970897, PubMed:28178239). In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake (PubMed:11970897, PubMed:28178239). Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1 (PubMed:11970897, PubMed:28178239). Predominantly cytoplasmic in myocytes (PubMed:15897321). {ECO:0000269|PubMed:15897321}.
Interaction partners:
- Diacylglycerol O-acyltransferase 2
- Long-chain fatty acid transport protein 4
- Aspartate aminotransferase, mitochondrial
- Scavenger receptor class B member 1
- Platelet glycoprotein 4
- Beta-alanine-activating enzyme
- Fatty acid-binding protein, adipocyte
- Patatin-like phospholipase domain-containing protein 2
- Fatty acid synthase
- Hormone-sensitive lipase
Sequence:
MRAPGAGTASVASLALLWFLGLPWTWSAAAAFCVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL