wanglab/gogpt-training-data huggingface dataset:
Protein: Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Q922B2)
Organism: Mus musculus (Mouse)
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular location: Cytoplasm.
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Methionine--tRNA ligase, cytoplasmic
- Glutamine--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, cytoplasmic
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
- Arginine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase
- Eukaryotic translation elongation factor 1 epsilon-1
- Glutamyl-tRNA
Sequence:
MPSTNASRKGQEKPREIVDAAEDYAKERYGISSMIQSQEKPDRVLVRVKDLTVQKADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP
Protein: Microtubule-associated protein (H2KY94)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU000686}.
Interaction partners:
Sequence:
MEDIAPRELESLNFSETSGTSDQQADRIMQNNENERVEEKKQMSPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKSTSTRSIDNVGRMTPKVNAKFVNVKSKVGSVTNHKAGGGNVEIFSEKRLYNAQSKVGSLKNATHVAGGGNVQIENRKLDFSAASPKVGSKTNYQPAKSDVKIVSEKLTWQAKSKVGSMDNAAHKPAGGNVQVF
Protein: Methionyl-tRNA formyltransferase (Q8WRE7)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MRQCISRCGHSVARACFWSHISSFLVNRRSRSSTTDPPAPSTMVGCVEQVTITGNGDKTRGTPNCAFTVCGMSKPPSIIFFGGDIVSLVALKALHNRLQLIMDARPLQEKGCSAATGSEKSQLVVVCPFLPADPFTVFKQYRRQYPVARYCVEHGIPLVPVDHPTSMAKSKTLEYLLHPKHLPTPVISGVAQVDHIAGRPLEMFDVAVVVSFRYFLPNKLLEKLRFTVNLHPSLLPRYRGASPIFAPLLRGDDKGGVSVIKLPPRGMFMDGGDVLLQRTIPIPPEMTIREYFPSVTEQGAEALCECLFGKVPVAPALSSPTGCLHLGPAVASGYCDWPRTFNALWNAAWKQGHDLHFTKDPWHAPLLKRESAVIYWHKVTADEAYGIWRAFVGGEYFSPTINATLDKGATPVRGQLIKRLLSRTVCELEKQTVWHRGDQLSGERCNEGLPKEQQRDGHGGGGTDEGGNAVQRKDITVASSKPSEKVDDAEDAGSHDHFRHRLLVRCTFTDAVYPQGTPSAVQWELQRLEQGTVTHFRNLHDCGDCGSNAPTTESFIEAGSAYFPKSAEDICAVKCRVGWFLWNAVVLEGSRKQSAGLLRKGMAMKTGVLYPRLFVVQANDKGKCSSRDIGGRSASNANATVTACRSNLASC
Protein: Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) (Q62441)
Organism: Mus musculus (Mouse)
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor 7-like 2
- Lymphoid enhancer-binding factor 1
- Transcription factor 7
- Catenin beta-1
- Transducin-like enhancer protein 1
- Transducin-like enhancer protein 3
- Histone deacetylase 1
- Paired box protein Pax-5
- LIM domain-binding protein 1
- Transcription factor 7-like 1
Sequence:
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
Protein: B-Raf proto-oncogene, serine/threonine kinase (A0A2R8YES9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVSQF
Protein: Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron-responsive element-binding protein 1) (IRE-BP 1) (Q0VCU1)
Organism: Bos taurus (Bovine)
Function: Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:1281544}.
Interaction partners:
- Citrate synthase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase subunit beta, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- ATP-citrate synthase
- Aconitate hydratase, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Citrate synthase
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Sequence:
MSNPFAHLVEPLDPAQPGKKFFNLNKLEDSRYGSLPFSIRVLLEAAIRNCDQFLVKKNDVENILNWKVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPICPADLVIDHSIQVDFNRRADSLKKNQDLEFERNKERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYRLVGNPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIKYLVQTGRDKEKVKHIKQYLQAVGMFRDFSDSSQDPDFAQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNNSKFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEAVVEAIVQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALAAPSDKLYCWNPKSTYIKSPPFFEDLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIRAVLAESYERIHRSNLVGMGVIPLEYLPGENADTLGLTGRERYTISIPETLKPRMKVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMTK
Protein: Holin (P51773)
Organism: Escherichia phage P2 (Bacteriophage P2)
Function: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space (Probable). Determines the precise timing of host cell lysis (Probable). Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell (Probable).
Subcellular location: Host cell inner membrane {ECO:0000250|UniProtKB:P03705}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P03705}. Note=Classified as a class I holin. {ECO:0000305|PubMed:23335412}.
Interaction partners:
Sequence:
MTAEEKSVLSLFMIGVLIVVGKVLAGGEPITPRLFIGRMLLGGFVSMVAGVVLVQFPDLSLPAVCGIGSMLGIAGYQVIEIAIQRRFKGRGKQ
Protein: Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor) (P01586)
Organism: Mus musculus (Mouse)
Function: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Interleukin-3 receptor subunit alpha
- Cytokine receptor common subunit beta
- Interleukin-3 receptor class 2 subunit beta
- Interleukin-5
- Interleukin-2
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-6
- Kit ligand
- Interleukin-1 alpha
- Interferon gamma
Sequence:
MVLASSTTSIHTMLLLLLMLFHLGLQASISGRDTHRLTRTLNCSSIVKEIIGKLPEPELKTDDEGPSLRNKSFRRVNLSKFVESQGEVDPEDRYVIKSNLQKLNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLNDLETVLTSRPPQPASGSVSPNRGTVEC
Protein: Malate synthase (MSH) (EC 2.3.3.9) (D4GTL2)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Involved in the glyoxylate cycle which synthesizes precursors for carbohydrates from C2 compounds such as acetate. Catalyzes the Claisen condensation between acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form the malyl-CoA intermediate that is subsequently hydrolyzed to produce malate and CoA.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Isocitrate lyase
- Malate dehydrogenase
- Pyridoxal phosphate-dependent aminotransferase
- 2-dehydro-3-deoxy-phosphogluconate aldolase, bacterial-type
- Malate dehydrogenase
- phosphoenolpyruvate carboxylase
- Fumarate hydratase class II
- Uncharacterized protein
- Dihydrolipoamide S-acyltransferase
- Triphosphoribosyl-dephospho-CoA synthase
Sequence:
MTERRHDREFVRTFFTSPTAVEGEDDSAKMLRRAAGLRGMQAPDVWVPDNEDATAPSMRDEGAENIVEVISEQGAEFPGEIHPRMVWHRDSPETRYQGFQHMLDITDPERGAVEHIHGFVIPEVGGIDDWKKADEFFTIVEHEHGLDEGSLAMSVIIESGEAELAMGDLRDEMGKPTNNLERLFLLVDGEVDYTKDMRAMTPTGELPAWPELRHNTSRGASAAGCVAVDGPYDDIRDVEGYRERMTDNQAKGMLGIWSLTPGQVVEANTSPLPPKTGSWLLDADGEEVELASEDGVEAYDGDRLSLEATDGGYELRVGGDARELTADELREELLGLTSYVPSMDDIVDSMEEFEAAKEAGRGAIAMTQSATLRIGGTEIDIEKDRMWDEATYQAAMTPISLFQDVYENRPDQHEELEERYGAGVVERAMEVGL
Protein: Packaging protein 1 (Packaging protein IVa2) (P03271)
Organism: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Function: Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04057}. Host nucleus, host nucleoplasm {ECO:0000255|HAMAP-Rule:MF_04057}. Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04057}. Note=Located at a unique vertex of the capsid. Present in about 6-8 copies per virion. {ECO:0000255|HAMAP-Rule:MF_04057}.
Interaction partners:
Sequence:
METRGRRPAALQHQQDQPQAHPGQRAARSAPLHRDPDYADEDPAPVERHDPGPSGRAPTTAVQRKPPQPAKRGDMLDRDAVEQVTELWDRLELLGQTLKSMPTADGLKPLKNFASLQELLSLGGERLLADLVRENMRVRDMLNEVAPLLRDDGSCSSLNYQLHPVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQICEGNYAPGPDGTIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAISLLLKDIFRHHAQRSCYDWIIYNTTPQHEALQWCYLHPRDGLMPMYLNIQSHLYHVLEKIHRTLNDRDRWSRAYRARKTPK
Protein: Putative uncharacterized protein HUR1 (P45820)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Calcium-transporting ATPase 1
- Ammonia regulation of amino acid uptake protein
Sequence:
MFILVSVVNICTYIHLHMFPLISTFTSIGLGVLMKDKGKEGKTIKAQNVTYQTFEKYVESSSFFFLVHNFLNSSTMKTLLLMSNNNSISEIPSFSVLKILWKNGIYIAHI
Protein: Dipeptidase 2 (EC 3.4.13.19) (Q9H4A9)
Organism: Homo sapiens (Human)
Function: Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Hydrolyzes cystinyl-bis-glycine.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q8C255}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8C255}.
Interaction partners:
- Dipeptidase 3
Sequence:
MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALTTLGAPRAHTMPGTYAPSTTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVNLRNFSYGQTSLDRLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQKLACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLTDFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDILQLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVSESSPHMAPVLAVVATFPVLILWL
Protein: Myeloid differentiation primary response protein MyD88 (Q99836)
Organism: Homo sapiens (Human)
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225, ECO:0000269|PubMed:37971847}. Nucleus {ECO:0000269|PubMed:21057262}.
Interaction partners:
- Lymphocyte antigen 96
- Interferon regulatory factor 7
- Toll-like receptor 4
- Toll-like receptor 3
- Toll-like receptor 8
- Toll-like receptor 5
- Toll/interleukin-1 receptor domain-containing adapter protein
- Mitogen-activated protein kinase kinase kinase 7
- Interleukin-1 receptor-associated kinase-like 2
- NF-kappa-B essential modulator
Sequence:
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
Protein: Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (G-protein coupled sensory epithelial neuropeptide-like receptor) (SENR) (Urotensin II receptor) (UR-II-R) (P49684)
Organism: Rattus norvegicus (Rat)
Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Urotensin-2
- Urotensin-2B
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
Protein: RING-type domain-containing protein (Q57WU1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proliferating cell nuclear antigen
- RuvB-like helicase
- Protein artemis
Sequence:
MVGNGNDTVLTDGDDDECIAEQEDKVTKALQARLRCGMQRFATSATNQGGLVKPSGPPSSVAAAAQRSTTTKRDNLTNSRRQEIFVEHVKHFMRYTVIADKARKLVSLEERPKEDPDVGNDRVELLRIHVSLPCVWRYILHEWERVEEASKKSSSLAASRDASVSRLVSLFMKCLNSLDGIHALLFIACAACRALDLTGGVTSVLLHLLLETGRVEEDRLLKSDSGELVYKAIEEIDKEMHSRFGGSDCCYFQTHSYLLLLIWYTQRDVSDNGGPLKMSHQVVLSQAFVKATSPYQTARTRRGSKAAASVAPSEESGKRKPRGRRCAGSSEDGAALSGFDRHATLVTEVQEHETRWAEDSSKFLFSLYALQNASGSASYGMKKLALREVMGAVFLFHRVLSESGVNDFLLESKESRIRELHEWSLSKGFVTPPLTHGGESSNNGTTVNSFASTDVGEDGLNVMSMAGRTYRECTDVERSFPRVANARAMLQHVTQIAAANYRGNTRAVGEGFPHEYIRARLHPHQVESLAYMLERETRGLAQYVELRGFFEATSGLPSEVADRSAGRGSREFSLFYSSMSSEWFIVRSDSLSARFARRALHCGFLCDEMGLGKTLVVLSLCATAKKRAIELEETEVPTVTTLGTVKGSNVGAVNKAFAESDAGTAGAGEDEPIYLWRHIRVRKTGAPWSDMLEVLYGSLPQPVYLPTPKPLPKTTLVVVPLSLLIQWVSEIDRFYPLARYILFHGPSRQRYTYEDFCSADFVITTYETVGAHLRVETDAAFRLLTMTLPYMEHKDASLAQWDTFCRGCNERRARAASASQGVNDCDGSADVFDSILSLFESARRQVVLEAEGAPPGPTLDFVSQWDKTFREFLRSDVLYLTDFVFERIILDESQKCSKTSRLQYLQARRRWVVSGTPINNNDVNSLQPLFKFLWAELSPSYSVSPLSAFYCSSYDKQRHMISALNAFRSSRKMARYAINSFYVGRHSKSSPSDTRHVLTQPAIRKPLCMCRLCNPFTKQTVYPKSPVLTLKDALYRRVTSAASEEETEGFISDRGGLFRSWRFSVPLTHLMVRHEKTEELQRALQLSPVTEAHVEVPLLDGERFLYDYAGDVVARGVALLQRQGLVGNCSAKLLSWVCLLGRMALHPSTAFADVRNSDQALYVQSHQKNEQVASNFLSSVVSVTPNDALAYARKLIANRLNTTGTRKGRGETNVLVPPETTVETLRKLTLDPPEVPECAICLDTMLHPTLLSCFHLFCKECLFATIQVARPTLSNETTARCPHCRNPKSMREKMMVIQVENTQVSTLGALQDEGMAPPNGENVSHEELKRRVDAVGRGSRIPRLIQLLEDIWDEAPDDNVLVFSKVPAILQMGEAALKEAGYQNVHVIDNHVTLVQRKKIFAQLHANAATTASATGSASGSTPSGNNRGHVLFLSSRVACSGLNLVFANRLIFMEPNLNPAQHQQAVGRIDRCGQLKRTYVYVMYAPRTIEERIMNRTSALLQEASQGTFPDVATGRGAPAGNTSSMGQSELITLLQAQQA
Protein: Protein lin-41 (Abnormal cell lineage protein 41) (Q9U489)
Organism: Caenorhabditis elegans
Function: Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repression of translation. Degrades the mRNA of transcription factor dmd-3 to govern the timing and extent of male tail tip morphogenesis. Plays a role in the sexual maturation of the nervous system.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10882102}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q2Q1W2}.
Interaction partners:
- Protein argonaute-1
- Zinc finger transcription factor lin-29
- Protein argonaute-1
- CCCH-type zinc finger protein oma-1
- ATP-dependent RNA helicase cgh-1
- Protein lin-14
- Piwi-like protein ergo-1
- Protein lin-28
- Protein LSM14 homolog car-1
- Hunchback-like protein
Sequence:
MATIVPCSLEKEEGAPSGPRRLQTEIDVDANDSGNELSMGGSSSEGDSMSHHRGEHSPNHHHQDNHLGSGPPPPQFTGSLFDTPPSMIQSPQQQPQFQFNTGFGLGLPQDSFRCSVCSKSSTIGVLPFVCAHKTCQSCYQMTPSSYDRRACKLCGAVSTATANFTSQMYLSPTLPSPPRGALMSDCSTPTMNNHINSSTPLHQPRAFSFSLSGMPGSPSPVMGARMPSSAGGLMMRPIGFPDSDSSLTSWSPLQQPSQLSINNLSSIGGHQQQSPMLMQNVFDSLAVNDDTPVFSPLSPTNTSMHMPPSLMASPDVPKHSATIAPPRNSMCSTPRLQLATPMSSQSQQTFPIPSPLGSQPQQQQPMGPIQCQGCESKISFAYCMQCQEALCIHCVQAHQRVRATKQHAFVELQQLMATLMSRAVQPQQAQQYTQNVGGSVRQALGSVGSGDVFFSGHVSGVENDSIGSGESSPRSSSVCGTHDSVIIGICENCPHSVLLCAICVAQHPGKHRVQPLGDIRVAVGEVVNESQLLQWQCEKTGDTIKQIIDGIVTNATTAENEIRAAFDTHVNALEERRKELLKRVETVKNLKLSVLISQAESLQSKQIDLQQAIQTATKLMDSSDCDEMVLRQVFEKLASCQMGNEGTEPNNNILNVLMLACQVNEDDRLKFTAPQDGILLNKARQFGNIESGPCAKNSSIVGDSFKKAIRERQTVIYVQLRDACGDLLSSSIAATQPTSQALLPHQEPHSHLEQAMPTSDVQAFVISPDGSTVEVTMTPRENGIVALSYYPSIEGSYTLNILVKGTPISGCPTTMDIRRGRNYDEIAAKGPILTFGKEGSGDGELCRPWGICVDQRGRVIVADRSNNRVQIFDKDGNFISKFGTSGNRPGQFDRPAGITTNSLNNIVVADKDNHRVQVFDENGMFLLKFGDRGRAVGYFNYPWGVATNSHNAIAVSDTRNHRVQIFTPQGQFVRKCGFDSAYFFKNLDSPRGLCYLPDGQLLITDFNNHRLAVLSPRNMSEMKVYGSEGDGDGMFVRPQGVVIDPEGHILVCDSRNNRVQVFASDDMRFIGSFGLGPVPNSGFQMPQELPAPYSSLGGPFGAPAFSSAPTPLTPSPRQLLDRPTDLAVGPDGRIYVVDFGNNCIRVF
Protein: CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (mCX3CR1) (Fractalkine receptor) (Q9Z0D9)
Organism: Mus musculus (Mouse)
Function: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection. Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10187784}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Fractalkine
- C-C motif chemokine 2
- C-C motif chemokine 5
- Stromal cell-derived factor 1
- C-C motif chemokine ligand 26
- OX-2 membrane glycoprotein
- Growth-regulated alpha protein
- C-C motif chemokine 3
- C-X-C motif chemokine 16
- C-X-C motif chemokine 10
Sequence:
MSTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSVFYALVFTFGLVGNLLVVLALTNSRKPKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKDNECLGDYPEVLQEMWPVLRNSEVNILGFALPLLIMSFCYFRIIQTLFSCKNRKKARAVRLILLVVFAFFLFWTPYNIMIFLETLKFYNFFPSCDMKRDLRLALSVTETVAFSHCCLNPFIYAFAGEKFRRYLGHLYRKCLAVLCGHPVHTGFSPESQRSRQDSILSSFTHYTSEGDGSLLL