wanglab/gogpt-training-data huggingface dataset:
Protein: Probable disease resistance protein At1g63360 (Q9SH22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable disease resistance protein.
Interaction partners:
- Probable LRR receptor-like serine/threonine-protein kinase At1g51810
- Uncharacterized protein T14D3.50
- Carboxyl-terminal proteinase-like protein
- Probable serine protease EDA2
- Pathogenesis-related thaumatin superfamily protein
- UBP1-associated proteins 1A
- DGCR14-like protein
- Probable lysophospholipase BODYGUARD 2
- Ras-related protein RABG3a
- PTI1-like tyrosine-protein kinase 1
Sequence:
MGISFSIPFDPCVNKVSQWLDMKVSYTHNLEKNLAALEKTMKELKAKRDDLERRLKREEARGLQRLSEFQVWLDSVATVEDIIITLLRDRNVEIQRLCLCRFCSKSLTRSYRYGKSVFLRLREVEKLKGEVFGVITEQASTSAFEERPLQPTIVGQDTMLDKAGKHLMEDGVGIMGMYGMGGVGKTTLLTQLYNMFNKDKCGFDIGIWVVVSQEFHVEKVQDEIAQKLGLGGDEWTQKDKSQKGICLYNILREKSFVLFLDDIWEKVDLAEIGVPDPRTKKGRKLAFTTRSQEVCARMGVEHPMEVQCLEENVAFDLFQKKVGQTTLGSDPGIPQLARIVAKKCCGLPLALNVIGETMSCKRTIQEWRHAIHVLNSYAAEFIGMEDKVLPLLKYSYDNLKGEQVKSSLLYCALYPEDAKILKEDLIEHWICEEIIDGSEGIEKAEDKGYEIIGCLVRASLLMEWDDGDGRRAVCMHDVVREMALWIASELGIQKEAFIVRAGVGVREIPKIKNWNVVRRMSLMENKIHHLVGSYECMELTTLLLGKREYGSIRSQLKTISSEFFNCMPKLAVLDLSHNKSLFELPEEISNLVSLKYLNLLYTEISHLPKGIQELKKIIHLNLEYTRKLESITGISSLHNLKVLKLFRSRLPWDLNTVKELETLEHLEILTTTIDPRAKQFLSSHRLLSHSRLLEIYGSSVSSLNRHLESLSVSTDKLREFQIKSCSISEIKMGGICNFLSLVDVNIFNCEGLRELTFLIFAPKIRSLSVWHAKDLEDIINEEKACEGEESGILPFPELNFLTLHDLPKLKKIYWRPLPFLCLEEINIRECPNLRKLPLDSTSGKQGENGCIIRNKDSRWFEGVKWADEATKKRFLPSCQLISLK
Protein: Insulin gene enhancer protein ISL-1 (Islet-1) (P50211)
Organism: Gallus gallus (Chicken)
Function: Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart development (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P61372}.
Interaction partners:
- Homeobox protein Nkx-2.5
- LIM/homeobox protein Lhx3
- LIM domain-binding protein 1
- Paired box protein Pax-6
- Neurogenic differentiation factor 1
- Transcription factor GATA-4
- POU domain, class 4, transcription factor 1
- NK2 homeobox 2
- T-box transcription factor TBX5
- Visual system homeobox 2
Sequence:
MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDETCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARAKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
Protein: Cytochrome c-1 (D3ZFQ8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Interaction partners:
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome b
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Cytochrome c oxidase subunit 1
Sequence:
MAAAAAASLRRSVLGPRGMGLPGASAPGLLGGARPRHLPLRTPQAVSLSSKSGPSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEEEAKALAEEVEVQDGPNEDGNMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIGMAPPIYTEVLEYDDGTPATMSQVAKDVATFLRWASEPEHDHRKRMGLKVKGWMLLMMGLLLPLTYAMKRHKWSVLKSRKLAYRPPK
Protein: Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15) (Biotin--[biotin carboxyl-carrier protein] ligase) (Biotin--protein ligase) (BPL) (Biotin-[acetyl-CoA carboxylase] synthetase) (I6YFP0)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the transfer of biotin onto a conserved lysine residue of the biotin carboxyl carrier protein (BCCP) domain of acetyl-CoA carboxylase and converts it to active holo-BCCP. Forms an acyl-adenylate intermediate. Cannot use GTP or desthiobiotin.
Interaction partners:
- Biotin synthase
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit
- Biotinylated protein TB7.3
- Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit
- Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit
- Possible carboxylase
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit
- Probable biotin sulfoxide reductase BisC
- Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase epsilon subunit
- Probable fatty acid synthase Fas
Sequence:
MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR
Protein: Hook microtubule tethering protein 2 (K7EMR5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGT
Protein: HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 (Hermansky-Pudlak syndrome 3 protein) (A0A0R4IZE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVHVYNCHPFAAQRIVSAEQEPGLVCCGGGALFVVSAGGCKIEAFDLQREESPVICRFSCAGTVLSLQHSAVGDYLVTIEEKNNATYLRAYTNWRYQAVEKTRVGVRLLGHLLRGSSFRGAPKEQMEIIEIPLFEPPLCVACCSLTGDLLVGSAKSLVVFSLKRQTLSEQLSVLDFERVLILHIQGWSPSQVAFCAGYLALQTELEVLVIKLVQQQKSAQTAEENALLPVDIMVETSLEDDAEMKKDGFSPLHEQEDFFVFPKHQEMLGSEAQHCGITLVPECTAMDSESRGETTVVYVLFRRFAPDFFQGCSVEETRLHSLQLHPIFTGKQEESSISRCGDPDCMFVFFSLPNTGYMYSLKSSVELVSTYQYPEKAHQAVLSDQFLYVITRNALQCFTVRCSAVAARVQDPYIDTTMKACPPFSMEVCALRIQLFIGLKVLCQDGDHIVLLTAADVDSKENTERPARKNTSRKSSVCKSTEAPDSAHGWNLYVISSVSTLQLYREIVEYSKRYEQSNPCSQSCVHLLSEAHLLLRSALLKLQNGPAEEKQELLEAFQESCAHLGDCFSRFDKKDCHLALPYYKMSGLTVTDVIQRNVSMSGVSSGYGRGFIFFLKHSLYEETVEELSKDVADKVLEIFSVAEPAQLPHVVCCSSMLNADPDGAGALLEQLEASGAPSITLALCRASLALRTGDRHTYSQQMERHAEMLQVYGFIEEPRLLLHGRGVGLMPTLLAQQLRDSQDGLLVAALVALHENSRISLEDAHLFFQELCKDRLEPDSSPQLLVDFWESLLVASSRESTIQELLFRLVSVYISRITCSHPSGCKALKTADDLINSCSHYGMLYPWVSILTPNLYHDQQEDLLKLQSLLCGPTLQVSSILPLLEPLSDSDDPGLSVHVLCSTKLGQHEDSIHRLLDRCPQAIIPYAQHQLHHHTLCLWWQKLFPEVCDRIRKTGNDNTILLSALKETLIVAARELTPLEFLDLLPDDGTAHFFLPHLLECCQ
Protein: Ras-related protein Rab-27B (EC 3.6.5.2) (Q99P58)
Organism: Mus musculus (Mouse)
Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:O00194}; Lipid-anchor {ECO:0000250|UniProtKB:O00194}. Late endosome {ECO:0000250|UniProtKB:O00194}.
Interaction partners:
- Melanophilin
- Synaptotagmin-like protein 4
- CD63 antigen
- Protein unc-13 homolog D
- Ras-related protein Rab-27A
- Synaptotagmin-like protein 5
- Synaptotagmin-like protein 2
- Exophilin-5
- Rabphilin-3A
- Synaptotagmin-like protein 1
Sequence:
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGASGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKRMEKCVEKTQVPDTVNGGNSGKLDGEKPAEKKCAC
Protein: Acyl carrier protein (ACP) (Cytosolic-activating factor) (CAF) (Fatty acid synthase acyl carrier protein) (P0A6A8)
Organism: Escherichia coli (strain K12)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- Malonyl CoA-acyl carrier protein transacylase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- NADH-quinone oxidoreductase subunit C/D
- Holo-[acyl-carrier-protein] synthase
- Pimeloyl-[acyl-carrier protein] methyl ester esterase
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Enterobactin synthase component F
- Enoyl-[acyl-carrier-protein] reductase FabI
Sequence:
MSTIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYINGHQA
Protein: Probable insulin-like peptide beta-type 2 (Q09627)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MNAIIFCLLFTTVTATYEVFGKGIEHRNEHLIINQLDIIPVESTPTPNRASRVQKRLCGRRLILFMLATCGECDTDSSEDLSHICCIKQCDVQDIIRVCCPNSFRK
Protein: BTB/POZ and TAZ domain-containing protein 3 (BTB and TAZ domain protein 3) (Q9SYL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Essential for female and male gametophyte development.
Interaction partners:
- AT5g45310/K9E15_9
- Adenine nucleotide transporter BT1, chloroplastic/mitochondrial
- TRF-like 8
- Protein NUCLEAR FUSION DEFECTIVE 4
- Subtilisin-like protease SBT3.4
- Serine/threonine-protein phosphatase PP-X isozyme 2
Sequence:
MSSSTKNIPKPPPLPCITYQRFQSSTRKPSSLMRLVPKEALETWDKLFKEGSGADTYVETDNKSHFPAHSSVLAAASPVIATLLNQSRDKNGNTYLKIHGVPCEAVYMFIRFLYSSCYEEEEMKKFVLHLLVLSHCYSVPSLKRLCVEILDQGWINKENVIDVLQLARNCDVTRICFVCLSMVIKDFKSVSSTEGWKVMKRSNPLLEQELIEAVIESDSRKQERRRKLEEREVYLQLYEAMEALVHICREGCGTIGPRDKALKGSHTVCKFPACKGLEGALRHFLGCKSRASCSHCKRMWQLLQLHSCICDDSNSCKVSLCWNFKEKMKKLSKKEQSKWRLLVENIIRARNSLGPFSSRSSGLI
Protein: Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) (Q06413)
Organism: Homo sapiens (Human)
Function: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A0A096MJY4}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}.
Interaction partners:
- Homeobox protein Nkx-2.5
- Histone deacetylase 4
- Transcription factor GATA-4
- Myogenin
- Myoblast determination protein 1
- Mitogen-activated protein kinase 7
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Myocyte-specific enhancer factor 2A
- Catenin beta-1
- Histone deacetylase 5
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (F1LQC5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Bone morphogenetic protein 4
- Bone morphogenetic protein 7
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein 10
- Growth/differentiation factor 2
- Bone morphogenetic protein 6
- Serine/threonine-protein kinase receptor
- Growth/differentiation factor 9
- Activin receptor type-1
- Bone morphogenetic protein 2
Sequence:
MTSSLQRPFRVPWLLWAVLLVSTTAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSSNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSVSMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNGGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTSGLTPSTGMTTISEMPYPDETHLHATNVAQSLGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQLYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGVVPSGQAANIVAHRAQEMLQNQFNGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVPTQGVTSTAADPGPAKPRRAQRPNSLDLSATNILDGSSMQSESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL
Protein: Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) (P60519)
Organism: Bos taurus (Bovine)
Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy (By similarity). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P60520}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P60520}. Golgi apparatus {ECO:0000269|PubMed:10747018}.
Interaction partners:
- Next to BRCA1 gene 1 protein
- Ubiquitin-like-conjugating enzyme ATG3
- Ubiquitin-like modifier-activating enzyme ATG7
- Cysteine protease ATG4B
- Sequestosome 1
- Cysteine protease ATG4A
- Ubiquitin-like protein ATG12
- Autophagy related 14
- Autophagy protein 5
- Cysteine protease
Sequence:
MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF
Protein: Alpha-tubulin N-acetyltransferase (Alpha-TAT) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) (Q22XZ3)
Organism: Tetrahymena thermophila (strain SB210)
Function: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Interaction partners:
Sequence:
MEFNFIINKLVQLDQQGLGVYIPRASRSKVSSQQEQQLGQVLNTMGERSAIAQGLKQVITNYDKVQGTDQRVYIVAEGRTCQGFLKVGQKNLFYRDMMGNIKEIKPLCVLDFYVHESCQRQGYGKLLFEYMIQCEQTSPEKLAYDRPSPKLIAFLKKHYNLVKYIAQNNNFVVFDQYFRSDASSQNKQNQNTRSYSQPYSDYSSQIPTNYPQQQQQQSNSKSYPYKQENNIDLMQHSSSRNNKEFLNAGRAILSKEEIYKKDNLSQQNIENTLNNINNSQYSTKSQQQQQYQKDYQLDKYENNWGADKNIKKPPFPGQDRQLDKIQQKIQQTERELDVVNQQIIKQRQNLSQDPLTQNHRAQNVYNTNQFGTSPWAQTGFNYYSTSSSNYGNHYTYYKK
Protein: Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II) (P00403)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Multi-pass membrane protein {ECO:0000269|PubMed:30030519}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 5
- Cytochrome c oxidase subunit 1
- NADH-ubiquinone oxidoreductase chain 4
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome b
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 7A2, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 5B, mitochondrial
Sequence:
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
Protein: Uncharacterized membrane protein YDR090C (Q03193)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Vacuolar arginine/histidine antiporter YPQ2
- Golgi apparatus membrane protein TVP23
Sequence:
MISEKAATALATIATVCWCVQLIPQIIYNWKKKDCTGLPPLMMFLWVVSGIPFAIYFCVSKGNVILQVQPHLFMFFCSISFVQSCYYPPISMARSKIVMIVAAIIAADVGMEVGFILWLRPLYEKGVKWPDLIFGISASVLLAVGLLPPYFELAKRKGRVIGINFAFLFIDSLGAWLSIISVILGNMDIMGIILYSIVAGMELGIFASHFIWWCRFRFLAKGNTFDEESGQAQKEEPDEKIEQDISKSDRNVTNYNLDNCSIPDDASSFADDFNIYDSTDGGTLSRAQTLHAVHGVVVRTDPDRYSRLSV
Protein: Membrane protein of ER body 2 (F4KFS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity. Not essential for the accumulation of ER body components, including PYK10.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23166355}; Multi-pass membrane protein {ECO:0000269|PubMed:23166355}. Note=Located in ER bodies.
Interaction partners:
- TSA1-like protein
- Beta-glucosidase 23
- Transcription factor NAI1
- MD-2-related lipid-recognition protein 3
- PYK10-binding protein 2
- Beta-glucosidase 21
- Vacuolar iron transporter 1
- Jacalin-related lectin 22
- Membrane protein of ER body 1
- Inactive GDSL esterase/lipase-like protein 23
Sequence:
MEKSNQPVHVTLSELKDGDKEIVDAEFLVDLLESYRFGKDNVPAREFRSKAAATAPAPVNTTEIELEEDNDGSQAQGNNSVSESTSSLFSDSDPIVLESTVSETGSNEESETGSNEENGNNWLESSSTNLPNVENKRQRNGEDCEIEEEEENNERSLSDSEEKSNLEKLLGTQENYELGNEDEEKNERSSSDSEEKSNLENLLATQENYELYCPSCSTCITRNVVLKKRKRGKHVNSSLDLKPDIPVVEPDEPSDIEEMESPVKVYVPETRIEDDQEDKEGTIFTCLVCDLKYFIRLGTKFLQLDYIRGKPVEKSVEEYIDVRKSINTTQSPPQIQPDGERFAIELLKSTVYGGLTETITSLGVVSSASASGSSTMNILALAVANLAGGLIVLAQNFQDLRNSSDQEKDRYEELLGRRTKSRIHILVAVMSYIFFGLIPPLVYAFSFYETGIKNYKLISVFLGSLVCVILLGSIKVYVRKPTNSCGSTKAYLKSAAYYTSIVVASCGISYVVGDIMGEYIEKLSLVGLDQISITSPCYGIKPEECRFTSF
Protein: ER lumen protein-retaining receptor (Q384K5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU000634}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU000634}.
Interaction partners:
- Coatomer subunit gamma
- Coatomer subunit beta
- Coatomer subunit beta'
- Coatomer subunit alpha
- Coatomer subunit zeta
- Coatomer subunit delta
- Coatomer subunit epsilon
- Vesicle-associated membrane protein, putative
- SEC7 domain-containing protein
- ADP-ribosylation factor GTPase activating protein, putative
Sequence:
MMYIRTFGDMLHLLAIFILLGKMLRGRSAAGLSLKTQFLFALVFTTRYLDLFLSFISVYNTMMKIFFLATSWHICYLMRCKSPWKTTYDHENDTFRIRYLIIPSFVLALLFNGHQHGMWVMDVLWAFSQYLESVAILPQIFLLEYTERYEALTSHYLAAMGAYRLFYLIHWIARYFVHGSVNAVSVCAGVLQTVLYVDFFYHYISQVVWRAKQRYDLAR
Protein: RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) (Q9UBF6)
Organism: Homo sapiens (Human)
Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:16874460}. Nucleus {ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:16874460}.
Interaction partners:
- Cullin-5
- Elongin-C
- Cullin-1
- Elongin-B
- Cullin-4A
- NEDD8-conjugating enzyme UBE2F
- Cullin-2
- Ubiquitin-like protein NEDD8
- Core-binding factor subunit beta
- S-phase kinase-associated protein 1
Sequence:
MADVEDGEETCALASHSGSSGSKSGGDKMFSLKKWNAVAMWSWDVECDTCAICRVQVMDACLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK
Protein: Cytoplasmic polyadenylation element binding protein 4 (A0A0G2K3Y6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Aurora kinase A
- Cyclin-dependent kinase 1
- RNA-binding protein FXR1
- Fragile X messenger ribonucleoprotein 1
- Fxr2 protein
- Symplekin
Sequence:
MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPNPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKAEENPGDNSSENSNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGASQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDSIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFTHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN