wanglab/gogpt-training-data huggingface dataset:
Protein: Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) (Q6DFV3)
Organism: Mus musculus (Mouse)
Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. {ECO:0000250}.
Interaction partners:
- ADP-ribosylation factor 1
- Prickle-like protein 1
- Prickle planar cell polarity protein 3
Sequence:
MMATHWTGLPEEDGDKLKACGAASACEVSKNKDGKDQGEPVSPSEDEPFSWPGPKTVMLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVAYSQDAYLKGNEAYSGNARNIPEPPPVCYPWLPSTPSATAQPVETCPPDSLPNKQQTSAPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLANRNNPSGPSHRTEEVRYGVNEQASTKAASRTTSPASVPTAHLIHQTTGSRSLEPSGILLKSGNYSGHSEGISSSRSQAVDSPPVSVNHYSANSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSAADYNQVVPTRTTLQVRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPPVSFNNHRTRSWDYIEGQTEATATVNSESQIPDSNGERKQTYKWSGFTEQDDRRGIHERPRQQEMHKPFRGSNLTVAPVVNSDNRRLVGRGVGPVSQFKKIPPDLRPPHSNRNFPTTTGVSLQRGIAQDRSPLVKVRSNSLKVPPPPVSKPSFSQHSLASMKDQRPVNHLHQHSVLSQQTQFRSESTFEHQLETEVSSCLPGTSAKTSPQLSENLGTSDLELPAIPRNGDINLQEAEIQQPDVLDNKESVILREKPQSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHEIAHIPASAVISASTAHVPSIATVPPSLTTSAPLIRRQLSHDQESVGPPSLDGQHSSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKITDSQKSSEDSGSRKGSSSEVFSDAAREGWLQFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSETKRRNVFRLTTSDCECLFQAEDRDDMLSWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNSLLSKTEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRRGIPSIVRKTFEKKPAATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTAVQEENTVDSQPVPNIDHLLTNIGRTGVLPGDVSDSATSDSAKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDSVFFKKENTEQSHSEIKEESKRESETSGSKQRVVVAKESNTKKDSGTTKEEKKIPWEEPPPPHSSKRNRSPTLSCRLAMLKEGPRSLLTQKPHCEETGSDSGTLLSTSSQASLLRSSTKKSTSPETKHSEFLSIAGTTTSDYSTTSSTTYLTSLDSSRLSPEVQSVAESKGDEADDERSELVSEGRPVETDSESEFPVFPTTLTSDRLFRGKFQEVARVSRRNSEGSEASCTEGSLTPSLDSRRQQFSSHRLIECDTLSRKKSARFKSDSGSPGDTRTEKETPALAKMFDVMKKGKSTGSLLTPSRSESEKQEATWKTKIADRLKLRPRAPADDMFGVGNQKPTAETAKRKNIKRRHTLGGHRDATEISVLSFWKAHEQSADKESELSAVNRLKPKCSAQDLSISDWLARERVRTSASDLSRGEGLEPQAESPSVLGTPISTHSPPSQQPEARVAATSTLASTSQSPLFTPPQSPDQINRESFQNMSQNASSTANIHPHKQSESPDTKAETPP
Protein: RAD51-associated protein 2 (Q09MP3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLPQPTPRMAELRKPTSSLTPPEDPDSQPPSSKRLCLEEPGGVFKAGWRLPLVPRLSEAEKVWELSPRPFKGLLVSTNAIFDNSTDSCVEKSVSGKQICNLKCSNLKFQMSSCLQSPPSQSPDSDLRASGRSEAGLHDREAFSVHRSNSSKAGVSQLLPSTSIHDIHGIRNENRKQQFVQGRDNVHKENPFLDVTFYKETKSPFHEIKNRCKANSVVPSNKRENNISSSVLKISKSQNQPSLEIAKPSYFRDSGTISVPQFPMDLNSKMSSVYLKEIAKKKNDKKEAYVRDFTNIYWSQNRPDVKKQKLQNDKKTVEAENIFSKCYENDYPSLSSQNTCKRKDLISSNYCNCSSIQCNVRDSRKNFAILENANWEEAECLDSYVLTRLEKSQNWDCNVRHILRRNRGNCWIINNCKTKCENMKKTEEKWNWLLLLEIDLLSKEDYHCAKVINAYEEQSKLLVREILGSQTALITTVWLNGKGENDNTLQLRYNTTQKVFHVNNPFESFIIEIFYFHKSISGNKKDNSILTCCNILKCKKQIGIIGIQNLITRNMNTNIKNGILSIYLQDSVSEPLDILLKTNIAFLLNNFDSLTRIENDFELEEECIFKCMLYLKYPKNIVENHTAYLVKILTSSRLLEDNMKPMLKKRKLFRTEQVFEKSKKKLINSFSMTTQNTGFPIFETYEKIPLLMDFDDMDEISLIREITCQNMSCPQQVVNVENWAHYNSSTVKAHGNSCPQFIQNNRGYINENFYEVNMHSQDLNMERKQGHNKISNFDCEHIFEDLCNVRQQAIPASHNIIHNEETHTTSITQVLNFWNLLSEIEEKKYDLILKEEVKVTAESLTNSCQVHKDTKIEKEEKDSFFPMDDMFSVQSVSLISKEVNVEENKYVNQNYVTNTNEYESILPEREIANSKDFHRKNDSALYINHQFETGLSEGNDECFQDLAAKYLSTEALTIVKDFEMKRKFDLVLEELRMFHEISRENELLSTVETNNGQENYFGENDAEKVKMEIEKDLKMVVVNKIRASSSFHDTIAGPNMGKSHQSLFKWKTVPNNGEQEVPNESCYPSRSEEELLYSTSEKDCETPLPKRPAFLPDECKEEFNYLLRGGSHFPHGISRVRPLKTCSRPIRIGLSRKARIKQLHPYLKQMCYGNLKENF
Protein: CXXC-type zinc finger protein 1 (K7EQZ1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGAKHTVSGSRCCAPSTHGTPKCQLTRYAGAPLYVMSLSSRVTSAACPSASAIAITAGRSCGVRKWTWSACVCGTSWTSCLSRSAMCAQP
Protein: N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) (Q8CIB9)
Organism: Mus musculus (Mouse)
Function: Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q56NI9}. Chromosome {ECO:0000250|UniProtKB:Q56NI9}. Note=Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. {ECO:0000250|UniProtKB:Q56NI9}.
Interaction partners:
- Structural maintenance of chromosomes protein 3
- Structural maintenance of chromosomes protein 1A
- Sister chromatid cohesion protein PDS5 homolog A
- Double-strand-break repair protein rad21 homolog
- Wings apart-like protein homolog
- Sister chromatid cohesion protein PDS5 homolog B
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- MAU2 chromatid cohesion factor homolog
- Nipped-B-like protein
- Separin
Sequence:
MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNKKHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKYYLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKRPEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKECSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFHN
Protein: Armadillo repeat only 4 (At3g26600) (Orf 05 protein) (Q38957)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AAR2 protein family
- RING-type E3 ubiquitin transferase
- Oligopeptide transporter 2
Sequence:
MGEEESRIGDELSILVLTAERLRVAVDEAESFKTECGEVGKQVDRLAQMLRTLVRFVSSSSQQVYDRPIRRVIVDVKKNLERGFALVRKCRRHNIIRRVCTIINAADFRKVINLLESSNGDVKWILSVFDSDGDGSFGGGIVISLPPIATNDPILPWVWSLVASIQMGKLVDKIDAANQLGSLAGDNDRNKKIIVDEGGVSPLLRLLKESSSAEGQIAAATALGLLACDEDKVRSIVNELGVPIIVQVLGDSSVRVQIKVATLVARMAEHDPVAQDEFARQSVIKPLVTLLSLDVFVDDIHLSKHNSIHSLVQMNKEVEKDPSSKLYRPLKSSKSNVYRDIGGSGSRTGNFKKERDNENPEVKHELKVNCAEALWMLARGNVANSRRITETKGLLSLAKIVEKEVGELQYNCLMTLMEITAAAESSADLRRAAFKTNSPAAKAVIDQMLWIIKDVDSPILKIPAIQSIGSLARTFPARETRMIKPLVEKLGSSNQEVAITAVISLQKFVCPENFLCAEHSKNIIEYGAIPLLMKLIRNVEQQMQLQCLALLCYLSVNASNHQQLEQAKVLTVLEGAERLAGLQNMELRELVSKAIYQLSLYNAGSHSQMLSYVGP
Protein: C2H2-type domain-containing protein (Q5AJC3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Histone H3-like centromeric protein CSE4
- Histone H4
- Histone H3.1/H3.2
- Histone H3.3
Sequence:
MNTGIENDFKYLHSRNLQQLPNNNTKNPSQNIPYNYPSSDEDIEDEYYSDDESQNQLDYEINQLINQQNEKQFKNKFKQLENQSLQRFKSQWDAIIDKYSKIDDSTQSDEIDIVTGELITNNGHLDKLNQNHNQKGDITKMDIWRQDYGQQLENWRQRDFRMKKQAKQRKNEQRQILKKLDLFNKPIYGYPKFEKLEENDFLKQSPTKNKVPSGIESDESPTKKRRVFTDKKVVSKNSNYLEFSDDDDEEVENKSLYTKTVIAHGKLYKRESDNVLYGSSADTFSPYIDRQSFRPESNELQSEDSQDYESNLSSDISDDEYDDETYQSIIINDKKYSPKFKEHFDESETESISETPQPQTSSEETPGLSSQTEEISPSPHPESSFDDEYSIIEEPYYFLDVKSLPLPTIFNCAFIKCHYCTGNKKLYELHLLQSHSSTLAEMGYPINLNSQNAAYENSNTDSDKENHKIEFTRDITDVDLDKLYQVFPKTYKLPPQKEALTCGKELANGQTCQKFYLVQEQLDQHQEAGDECSDKRQVLFCPILGCGYLTDGGYKEWREHMITANHSQEETAEKETKKENLEKLISRPIATRKVSVKVPKFTETDFKVSFIDQGYESIDELFN
Protein: Membrane-bound O-acyltransferase GUP2 (Glycerol uptake protein 2) (Q08929)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable membrane-bound O-acyltransferase (By similarity). Together with GUP1, has an influence on the chemical composition of the yeast extracellular matrix (yECM) in yeast multicellular aggregates, such as biofilms and colonies.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26928762}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acyl carrier protein, mitochondrial
- L-2-aminoadipate reductase
Sequence:
MSMLRIWSCIVHFFSVQALDSRIKPDIEFKRRQRIFINSSKEENGSSSSAVTVTRNPVLSSNSPSPPLWNTWEFRLYYLAFTVVVPFMIKAALATSSESNPNYYKFSGLLAHGWILGRKVDNSDPQYRFFRSNFFLLAILILLQIILKKVFVKFSKIPKTKFDFACGLVFVCFMYGINSVKLFTHAFIFFTLAHSLKRKRLIAAFAIWSYGIFTLFINQKMKNLPFNNIAIILSPMDQWYKGIVPRWDFFFNFTLLRLLSYSMDFLERWHEQLSRQPSIDYDDRRPEFRKSLSGSTLQTIYESGKNVLEEKERLVAEHHIQDYNFINFIAYITYAPLFLVGPIITFNDYLYQSENKLPSLTKKNIGFYALKVFSSLLLMEIILHYIYVGAIARTKAWNNDTPLQQAMIALFNLNIMYLKLLIPWRLFRLWAMVDGIDAPENMLRCVDNNYSTVGFWRAWHTSFNKWVIRYIYVPFGGSNNKILTSFAVFSFVAIWHDIQLRVLFWGWLTVLLLLGETYITNCFSRYRFRSWYRFVCGIGAAINICMMMIINVYGFCLGAEGTKLLLKGIFNNSHSPEFLTAVMVSLFIAVQVMFEIREEEKRHGINLKC
Protein: Cobalt transport protein CbiQ (Energy-coupling factor transporter transmembrane protein CbiQ) (ECF transporter T component CbiQ) (Q05598)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cobalt transport protein CbiM
- Cobalt transport protein CbiN
- Cobalt import ATP-binding protein CbiO
- Cobalt-precorrin-5A hydrolase
- Cobalt-precorrin-6A reductase
- Cobalt-precorrin-5B C
- Cobalt-precorrin-7 C
- Probable cobalt-factor III C
- Cobalt-precorrin-2 C
- Sirohydrochlorin cobaltochelatase
Sequence:
MTGLDRLSYQSRWAHVAPQRKFLLWLAMMILAFVLPPVGQGIELLIIAGLSCWLLRISLWRWCRWMAIPFGFLLVGVITIIFSISREPQMLLAGISVGPYWIGITRAGVVTANETFWRSLTALSATLWLVMNLPFPQLISLLKRAHIPRLLTEQILLTWRFLFILLDEAVAIRRAQTLRFGYCSLPNGYRSLAMLAGLLFTRVLMRYQQMTTTLDIKLYQGDFHL
Protein: Parathyroid hormone 2 receptor (Q32PR7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MLTVSLLILCKPSSSPSPVKIIPVDDLPATAELRASVLRVSLPKTFIKSFLNHLLQAGEDGEITAEEQVQMLLDAKLQCLQKVSSDDPAVGVCVPEWDGLICWPQGFPGTLTKTPCPGYIYDFNHAAHAYRRCDSNGSWVLAESSNKTWVNYTECIKSPEPNKKRQVFFERLHIMYTVGYAVSFSSLLVAIFIIGYFRRLHCTRNYIHMHLFVSFMLRAASIFVKDHVVHTSAGLQEFDAVLMNNFTNAVDVAPVDTSQYMGCKVTVLLFIYFLATNYYWILVEGLYLHSLIFMAFLSDSKYLWGFTLIGWGEYTRVNALEKAICQYNRFCRFVTYLSK
Protein: Prothymosin alpha (B8ZZW7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQTFGPAGVAAVGRRVESPADRRATRARATASSACRPGVSKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD
Protein: Sigma intracellular receptor 2 (S2R) (Sigma-2 receptor) (Sigma2 receptor) (Meningioma-associated protein 30) (MAC30) (Transmembrane protein 97) (Q5BJF2)
Organism: Homo sapiens (Human)
Function: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
Subcellular location: Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:19583955, ECO:0000269|PubMed:34233061, ECO:0000305|PubMed:27378690}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated (PubMed:19583955). Localized at cell membrane, probably in lipid rafts, in serum-starved conditions (PubMed:30443021). {ECO:0000269|PubMed:19583955, ECO:0000269|PubMed:30443021}.
Interaction partners:
- Membrane-associated progesterone receptor component 1
- NPC intracellular cholesterol transporter 1
- Sigma non-opioid intracellular receptor 1
- Protein lifeguard 4
- Sterol regulatory element-binding protein 2
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
Protein: Coenzyme Q8B (M0R307)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEM
Protein: FI05352p (Phosphatidylinositol 4-phosphate 5-kinase 59B, isoform A (EC 2.7.1.68)) (Q9W1Y2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASGDGDTINTIDMDSSSASQAKLAEPSNASTDHVGNSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVPPGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIHDGETVSVCRPSFYAQRFQNFMAKTVFRKIPSPLKHSPSKRKSLSKAIQRSIDSDNEVASRPVHASHSHSSGKIHQPAKPPTTEPTPAGAAGGAERGATALGPATTSGASERAPPPVKQRTPAASNLKTRVPPPVPPRGSPRRKDAQDRTTPGTTPSCSSTPPPAFDDISEDSSNKNSSSSIGRRSHHHHHHHQQSQQHQQSYYLDRKMNIGPAYRGSYKEDIVSVSEVHLDTLLAVDTSSSSQYGSRGGLAWTPPASGEGSTPTWTEGTPSFTDSSSSGDLDQLT
Protein: Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3) (P70423)
Organism: Mus musculus (Mouse)
Function: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine. The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Solute carrier family 7 member 13
- Solute carrier family 7 member 12
- Amino acid transporter heavy chain SLC3A2
Sequence:
MLWQALRRFGQKLVRRRVLELGMGETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISRTLKGTILLKMPHVLAEYPDFFALALVLLLTGLLVLGASKSALVTKVFTGMNLLVLSFVIISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISMFICFLAYFGVSSALTLMMPYYKLHPESPLPEAFSYVGWEPARYLVAIGSLCALSTSLLGSMFPMPRVMYSMAEDGLLFRVLAKVHSVTHIPIVATLVSGVIAAFMAFLFELTDLVDLMSIGTLLAHSLVSICVLILRYQPDQEMKSVEEEMELQEETLEAEKLTVQALFCPVNSIPTLLSGRVVYVCSSLLAVLLTVLCLVLTWWTTPLRSGDPVWVTVVVLILGLILAISGVIWRQPQNRTPLHFKVPAVPLLPLVSIFVNVYLMMQMTAGTWARFGIWMLIGFAIYFGYGIQHSMKEVKNHQTLPKTRAQTIDLDLTTSCVHSI
Protein: Sirtuin 1 (B3FK65)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MEDEAALALQPGGSPSAVAAEREAPSPPAGEPLRKKPRRDGPGVGRSPGEPGGAALERELPAAAGGCPAAAVLWRETAAGGEREAQAAAAAGEGNNGPGLQGLSREAPPADDFYDDDDDDEGEEEEEAAAAAAIGYRDNLLFGDEIVTNGFHSCESDEDDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAHLSELPPTPLNISEGSSSPERTSPPASSVTLPLLDQATKSNVDDLDVSESKDCVEEKSQEVQTSRSIESVKEPMESPGLKNVACSNGEKNERTSVAETVRKCWPARLAKEQISKRLDGNQYLFLPPNRCIFHGAEVYSDSEDDVLSSSSCGSNSESGTCQSPSLEEPMEDESEIEEFYNGLEDDADVNMRAGGTGFGADGSDQEAVNEAISMKQEATGVNYPSNKS
Protein: Growth hormone (H6UQ62)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MAPGSWFSPLLIAVVTLGLPHETVATFPTMPLSNMFANAVLRAQHLHLLAAETYKEFERTYIPEDQWYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMEVVRFSLVFIQSWLTPVQYLSKVFTNKLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
Protein: Ribosome maturation protein SBDS (Q9VRY5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ribosome assembly protein 1
- Large ribosomal subunit protein eL43
- Ubiquitin-ribosomal protein eL40 fusion protein
- Large ribosomal subunit protein uL5
- Ribosome assembly factor mrt4
- Eukaryotic translation initiation factor 6
- Small ribosomal subunit protein eS12
- Eukaryotic translation elongation factor 2
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL18
Sequence:
MSKIFTPTNQIRLTNVAIVRLKKGGKRFEIACYKNKVLSWRSNSEKDIDEVLQTHTVFTNVSKGQAAKKDELQKAFNKTDETEICKEILSKGELQVSEKERQSCLDTQLNSIVNSVAALCVNPETRRPYPASIIEKSLKDAHFSVKMNRNTKQNTLEAIKILKDHMPIERSRMKLRVSFAGKEGGGKLKESVVKLANAVEHEEWDEATLHLTLLIDPGQYRVIDELVRNETKGKGLLELLELKEVVESEELF
Protein: Bud20p (Q59SC5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MELLFTSSYFRQVIVNNLILDGFTLYYQIDIQNLDAHRKGSAAAATRATGQKHLKPEKAYTKLASSVMLIYCTATITQSTRVSAKWLICMLYGTNQITCTVVSCLCSYLLPGK
Protein: Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein homolog) (Q8JZM7)
Organism: Mus musculus (Mouse)
Function: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- RNA polymerase-associated protein CTR9 homolog
- Superkiller complex protein 8
- RNA polymerase-associated protein LEO1
- RNA polymerase-associated protein RTF1 homolog
- FACT complex subunit SPT16
- RNA polymerase II-associated factor 1 homolog
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB1
- Transcription elongation factor SPT4-A
- Transcription elongation factor SPT6
Sequence:
MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
Protein: Protein REBELOTE (Q0WVH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Collaboratively with CYP40/SQN and ULT1, influences floral meristem (FM) determinacy in an AGAMOUS and SUPERMAN-dependent manner, thus contributing to the floral developmental homeostasis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:18441215}. Nucleus, nucleolus {ECO:0000269|PubMed:30338215}. Nucleus, nucleoplasm {ECO:0000269|PubMed:30338215}. Note=Observed in the nucleolus of root cells in interphase and colocalizes with DNA in dividing root cells. {ECO:0000269|PubMed:30338215}.
Interaction partners:
- Pescadillo homolog
- Nucleolar complex-associated protein 3
- Protein SLOW WALKER 2
- Ribosome biogenesis protein BOP1 homolog
- Probable rRNA-processing protein EBP2 homolog
- At4g01560
- Ribosome assembly factor mrt4
- Ribosome production factor 2 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- AT5g04600/T32M21_200
Sequence:
MGKLGKKARKFAKKNLQSVEKRSRKLKPFIKKKFAKRNERHQAGDKQEKKVEQQPKKRCQEEEFQDIAIDAVFGKDDDEVLRDGDSDSDGYLDELVNETDSDIMKCKVLSRSFLATCCDMVDKEQYVPALVRLLNWYRAACQYGHEPSGIARPNIYYDIEDSETFAKVIIFVLQKADHTFRSILGLSDSSTKEKILKLKNNPKWDSLKPLVKSFFRSTLHLVKQAGDLEIISFTLTQLRVSIVFLAAFPDLLKKLIKISVHLWVTGEETISQQAFLILKDISMVFNSECFDSCLINMYKAFLHDCDIPKANSEQRPFLRDSLVELCSQDVQKSYTKASVSITQLAKLLKMALATKNKEAVEKIHSGEYINCVDLWVNFISANVQDCDLQPLLYTIVQVINGVAQLIIGPRYLLLRVKCIHWLNHLSRTSGIFIPIASLVLDMLEYKTTNDGEKQEQKLEAVSTVKLPKNWLKSQNFQEQCIFSVIELLAVHFAQWSFHISFPDLATIPVMRLKKFHERSTMEGLKRVVKRFIEQVESNIEFVQRKRDDVTFSPNDQQSADTFMQLEKQNANAPYTQYYQSIIDKALGTNKKKKK
Protein: F25A4.4 (GNS1/SUR4 membrane protein family) (Q9S804)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Elongator complex protein 4
Sequence:
MTTFNYYLAEHPTIVNFRWSPTQSYASTWSFLFTAVSSYIIAAVTLHLLLLITLSLSNRRRGFSLGPIPALHSLTISIISAVIFVGILLSAAAEIRDTRWLWRRTRTTALQWFLCFPVGTRASGRVFFWSYAFYLSRFLHLFRTFFSVIRRRKLSFFQLINQSSLLCISFLWLEYSQSFQVVAILLTTVSYAVVYGYRFWTEIGLRGACFPFVGNCQAILLGCMTVCHVGVLCIHLVKRGGCNGIGAWLFNSVLNAVITLLYLKFYCKTRSMMTKANHNTT
Protein: IP12572p (IP12772p) (Secretory chloride channel, isoform A) (Secretory chloride channel, isoform B) (Q9VVH4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- RH55021p
Sequence:
MMNLHLSEIFWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTFVYVL
Protein: Kappa-casein (Q5ZGI1)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
VLSRYPSYGLNYYQQKPVALINNQFLPYPYYAKPAAVRSPAQILQWQVLSNTVPAKSCQAQPTTMARHPHPHLSFMAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV