wanglab/gogpt-training-data huggingface dataset:
Protein: Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) (Q9NQZ2)
Organism: Homo sapiens (Human)
Function: Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 14 homolog A
- Nucleolar complex protein 4 homolog
- Nucleolar protein 58
- U3 small nucleolar ribonucleoprotein protein IMP3
- Neuroguidin
- WD repeat-containing protein 46
- KRR1 small subunit processome component homolog
- Bystin
- U3 small nucleolar RNA-associated protein 6 homolog
- U3 small nucleolar RNA-associated protein 4 homolog
Sequence:
MVGRSRRRGAAKWAAVRAKAGPTLTDENGDDLGLPPSPGDTSYYQDQVDDFHEARSRAALAKGWNEVQSGDEEDGEEEEEEVLALDMDDEDDEDGGNAGEEEEEENADDDGGSSVQSEAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQSQQEAEEEEREEEEEAQIIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAETRVVKDLAKVSVKEKLKMLRKESPELLELIEDLKVKLTEVKDELEPLLELVEQGIIPPGKGSQYLRTKYNLYLNYCSNISFYLILKARRVPAHGHPVIERLVTYRNLINKLSVVDQKLSSEIRHLLTLKDDAVKKELIPKAKSTKPKPKSVSKTSAAACAVTDLSDDSDFDEKAKLKYYKEIEDRQKLKRKKEENSTEEQALEDQNAKRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRRAKIRRRGQVREVRKEEQRYSGELSGIRAGVKKSIKLK
Protein: Protein quaking-B (Quaking-related protein) (Q6P104)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9QYS9}. Nucleus {ECO:0000250|UniProtKB:Q9QYS9}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 31
Sequence:
MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEIGRVRKDMYNDTLNGSTDKRTSELPDAVGPIAQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDSQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAPRIMTGPTPVMPNAALRTPAPTAPTLMPLIRQIQTSALMPTGTPHPTATLLPQTPESGIIYAPYDYPYALAPATSILEYPIDSSGVLGMAFPTKG
Protein: DNA polymerase delta subunit 3 (Pol32 polymerase delta subunit 3) (Q9Y118)
Organism: Drosophila melanogaster (Fruit fly)
Function: Accessory component of the DNA polymerase delta complex and possibly the DNA polymerase zeta complex (By similarity). As a component of the delta complex, participates in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair. Required to recruit the DNA polymerase delta complex to the nucleus of rapidly dividing embryonic cells, and as a consequence is essential for genome replication during the earliest cell cycles. Increases the efficiency and processivity of DNA synthesis of the DNA polymerases during mitotic DNA replication and repair. During development this function is essential for preventing replication stress that results in the formation of chromosomal fragile sites (CFS) such as chromosomal breaks. Ensures genomic stability by promoting several types of DNA repair mechanisms including repairing broken dicentric chromosomes through homolog-dependent break-induced replication (BIR). During homologous recombination (HR) repair, required for maintaining the processivity of the delta complex during break-induced replication; a form of HR that requires extensive DNA synthesis such as the repair of large gaps. Able to suppress position effect variegation and may therefore have a role in the induction of chromatin state changes that likely include its activities in DNA replication and repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:31100062}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31100062}. Note=During oogenesis, detected in the nuclei of nurse cells, follicle cells, and in the nucleoplasm of the oocyte. In syncytial cell cycles, accumulates in the nucleus during interphase but disperses into the nucleoplasm at the onset of mitosis. {ECO:0000269|PubMed:31100062}.
Interaction partners:
- DNA polymerase delta subunit 2
- DNA polymerase delta catalytic subunit
- DNA polymerase zeta catalytic subunit
- DNA polymerase zeta subunit 2
- DNA repair protein Rev1
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon catalytic subunit 1
- DNA primase small subunit
- DNA primase large subunit
- Replication protein A 70 kDa DNA-binding subunit
Sequence:
MSLKKALDDCMIDFDRCVLVTDLLEEYKLSYKEVNDVLEAYIKEQEPATKFEKRFLVHGKRKTQGSDSGEDLYSVVLESRMQDWLAKVQDAESQLYSVKIAGGTKAPAAIFKPMQHLEVKLAKVEQRPGAGKIVPSANGTTPHNGVKSEPTKSEPSKSAVKLEPSKSSLKSEPAKSKAEKPVASKSSPEDKKTSPKEQASKAKPAAAKKGSINSFFTAAASKPKDVKATPSKSTSGTVDNFFKKQPAGAKKSPPESEDKSKKDASNSNKKEASKKKSPSPTKKPTTANTSMQLFDEESAESSDEEEKLDMLRRKVIESDNDSDQEKASSSKRRRISDSEDEEQPPKKSADEETIALDEKMDTEPANETYLDEDGFVITQRKPTKAQPANKKVSPKAAAPVNKKKSPPSAAKAGKDAPKTKQAGIMNFFSKK
Protein: At4g37330 (Cytochrome P450, family 81, subfamily D, polypeptide 4) (Cytochrome P450-like protein) (O23155)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Glucose-methanol-choline
- AT3g56060/F18O21_20
- Uncharacterized protein At5g08430
- ABC transporter D family member 1
- Mediator of RNA polymerase II transcription subunit 31
- Glucose-methanol-choline
- AT5g51950/MSG15_3
- ABC transporter D family member 2, chloroplastic
Sequence:
MDLNQILILSFLSLFTLAIFLLTRSKRKLNLPPSPAISLPVIGHLHLLKPPLHRTFLSLSKSIGNAPVFHLRLGNRLVYVISSRSIAEECFTKNDVVLANRPKFTISKHLGYNATYLLSASYGDHWRNLRRIAAVEIFSTHRLNSFLYIRKDEIRRLISHLSRDSLHGFVEVEMKTLLTNLASNTTIRMLAGKRYFGEDNDDAKLVKNLVSEAVTSAGAGNPIDYLSILRWVSSYEKRIKNLGNRFDTFLQKLVDEKRAEKEKGETMIDHLLALQDIQPDYYTDVIIKGIILTLIIAGTDTSSVTLEWAMSNLLNHPEILKKARMEIDEKVGLDRLVDESDIVNLSYLQSIVLETLRMYPAVPLLLPHLSSEDCKVGGYDIPSGTMVLTNAWAMHRDPEVWEDPEIFKPERFEKEGEAEKLISFGMGRRACPGAGLAHRLINQALGSLVQCFEWERVGEDFVDMTEDKGATLPKAIPLRAMCKARSIVDKLI
Protein: Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36) (Q06696)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Involved in the trafficking of the plasma membrane ATPase. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12194858}. Endosome membrane {ECO:0000269|PubMed:12194858}; Peripheral membrane protein {ECO:0000269|PubMed:12194858}.
Interaction partners:
- Vacuolar protein sorting-associated protein 28
- Vacuolar-sorting protein SNF8
- Vacuolar-sorting protein SNF7
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein sorting-associated protein 20
- Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
- DOA4-independent degradation protein 4
- Vacuolar protein-sorting-associated protein 24
- Multivesicular body sorting factor 12
- Vacuolar protein sorting-associated protein 27
Sequence:
MEYWHYVETTSSGQPLLREGEKDIFIDQSVGLYHGKSKILQRQRGRIFLTSQRIIYIDDAKPTQNSLGLELDDLAYVNYSSGFLTRSPRLILFFKDPSSKDELGKSAETASADVVSTWVCPICMVSNETQGEFTKDTLPTPICINCGVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANHPQIGNCEICGHRLPNASKVRSKLNRLNFHDSRVHIELEKNSLARNKSSHSALSSSSSTGSSTEFVQLSFRKSDGVLFSQATERALENILTEKNKHIFNQNVVSVNGVDMRKGASSHEYNNEVPFIETKLSRIGISSLEKSRENQLLNNDILFNNALTDLNKLMSLATSIERLYKNSNITMKTKTLNLQDESTVNEPKTRRPLLILDREKFLNKELFLDEIAREIYEFTLSEFKDLNSDTNYMIITLVDLYAMYNKSMRIGTGLISPMEMREACERFEHLGLNELKLVKVNKRILCVTSEKFDVVKEKLVDLIGDNPGSDLLRLTQILSSNNSKSNWTLGILMEVLQNCVDEGDLLIDKQLSGIYYYKNSYWPSHI
Protein: Probable glycerol-3-phosphate acyltransferase, mitochondrial (GPAT) (EC 2.3.1.15) (Q22949)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phospholipid/glycerol acyltransferase domain-containing protein
- Glycerol-3-phosphate dehydrogenase [NAD
- Probable glycerol-3-phosphate dehydrogenase 2
- Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1
- Phospholipid/glycerol acyltransferase domain-containing protein
- Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
- Phospholipid/glycerol acyltransferase domain-containing protein
- Lysophosphatidylinositol acyltransferase 10
- Probable glycerol-3-phosphate dehydrogenase, mitochondrial
- Probable glycerol kinase
Sequence:
MELDVESTSITQLRSHCETCFPLMEEVVPRRERYVDLLEFSNFNGIPYPVVDPSRKPRRFLADFRYSWSIPLIHHYPNVEKDVLSSKRVHRVISKLKEQNDEQKNRAVQFFTEISARLSKFICKCCSYVLYKVFRRLMDKLLVCKEEMEVLYEAEQTGIPMVYLPLHRSHLDYLLITWCNWHFGLKLPHIASGDNLNLSGLGWLLRATGAFFIRRRVDPDDERGKDQLYRAILHSYIEQVLSKDMPIEFFLEGTRSRFGKALTPKNGLISNVVEAVQHGFIKDCYLVPVSYTYDAVVEGIFLHELMGIPKVRESVLGVFRGIFSGFSKSKQCGVVRMHYGRPIRLTEYLATITASLSSNHRTRPVRMTKLSTSFSYRELVPWHRTHSETVDDRTMIRAIGFHVVYEAQMMCSISPVAVVSCLLLAKWRGKVSRSTFERDCEWLCEKIIAEGGDVVGYQSKKTKGSALVKYAFEKLESCVEVTDEYVSPKESHSSFITLAYNKNSVICRFSIKSVIALTIVSRPSGTKLSIDQIVEDALSLCDWLQFEFMFCRPCDSLRELVHNVLGQKEWSDPIHGFLRSEIEDDGFLDAGGALNSGTLRVRDAKSRETLQFFANLVRPFVQSLYLISSFVVSEKCPTEPTSDNNIIRQLCQQSLAGDIDLPFAPLLESINSDSFKNALRVLKDKGLLQRSTPNSTARSGNSRLAELISNLERVLEVK
Protein: U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.346) (N(6)-adenosine-methyltransferase mett-10) (EC 2.1.1.348) (Q09357)
Organism: Caenorhabditis elegans
Function: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence. Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo.
Subcellular location: Nucleus {ECO:0000269|PubMed:19596901, ECO:0000269|PubMed:19752194}. Note=Accumulates in nuclei as cells enter meiosis (PubMed:19596901, PubMed:19752194). During meiotic prophase, expression is predominantly nuclear, but does not co-localize with DNA (PubMed:19596901). Recruited to the nucleus by dlc-1, a component of the dynein complex (PubMed:19752194). {ECO:0000269|PubMed:19596901, ECO:0000269|PubMed:19752194}.
Interaction partners:
- CTCHY-type domain-containing protein
- DNA N6-methyl methyltransferase
- Dynein light chain 1
- rRNA N
- Probable S-adenosylmethionine synthase 4
- Probable S-adenosylmethionine synthase 3
Sequence:
MSQNNEMHPRNPYRNKPPDFKALAVEYPEFRKFCQYVSNGKVTFDFKKDAAVRCLTQTLLKKDFNLDVEIPPGHLVPRVPQKLNYCLLIDDLLKANKLTKNVIGIDIGTGTSCIHALIGARQFNWKFIATDGDEKSVRVAHENVAKNGLSSSICVVHVNPDVKTVLMDVVNTIPDTDYAFCMCNPPFFEKGNGDDKFCEDISSSTETYSNRVASEFRTAPHSATFASSAELFVDGGEVAFVNRIIDDSVLLRDRIKIYTTMIGRKSSLKPLQNRLQRFGDDVKIMISVLNQGKTKRWMLAWTFSKSVSLTTIDRPISFQCPKPGLTRLMQEISILNGRLRQEDTLAIVAEFKCVTWTNQRARKRAKAILSESSIKKAKWNFSNVACQVAFGAGDGKDSYTDAGNFVSSESIPTNNLNAWDNASQAYFPLPNGEVPGPIIRIRIQVFSEDSYDSISFELISGSKQHLHQLVQYLKNLICR
Protein: Cytoplasmic protein (A7MNC6)
Organism: Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Interaction partners:
Sequence:
MLPDNLVPARYRIPTPDNHPSGEQNSENLTQGKPKLEEYETDILSGKSLAGQSGNVLLEERDRHIKARLLSVVKIEAYTKVLNKLVEDNAISAEELAELIATKTAQINEAGNKIWLNLITQEKDAPVFYKFED
Protein: Glutaredoxin domain-containing protein (Q20518)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MIQLRVQFLHFQSIFYHQNKAKIEHEKKSLNVIIIVVQNQIDDIKLIVGEYFKIKNLQMLKTIIDSFEYTLNKIAFEISKAKGQNFFIEKVEKLINNLNPFDVPIYENIQGVVLELNTQVSSMGNIPEKLEIKTQRETFQLEEENEIRMDNCRMMSGQAKIYKIFRKSVVLFVNYLEDEQTLSTIQSLNDNQIEYTIFDVSTDSEIRFISKALSDCETFPQLFVDGAFEPLPILKNLLPKLPKVYTMN
Protein: JmjC domain-containing protein 4 (Jumonji domain-containing protein 4) (Meiotically up-regulated gene 149 protein) (O94606)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- JmjC domain-containing protein 1
- Jumonji/ARID domain-containing protein 2
- Multicopy suppressor of chk1 protein 1
- Lid2 complex component jmj3
- Lysine-specific histone demethylase 2
Sequence:
MSELSTYKGYSPKHGDKVPVLQNLNDLTPKDFYDKFIATRTPVIIKSSLPESDWKGYLWQQQDYLLSKIGDIVCKVEPIDPVSGTFGQGMSRNEMSIKEFFQKLKNGERLYLTTQYDESNEVLDGDDEVSLLVKSLCPHPTDGLLTDFSITPALMGNLVPQQCNLWIGKSENGTSSGLHHDFHDNIYAVISGYKRFVIISPDHANQLKLSGKISKIHPNGLISYEGEDCPQRSDGLTELDAAIAKTQFLEKKIGSLKELAVPQESIELLEAEYENEMDRVLQMQIGGPEEDWNDLEEGDAASLLDGSVGGDPESDILLNEGNDIEATSLQDTKPELPDHFTKVSVNGLHKFMGFDDAKNVDVDKDELSALAGTVPLVVDLEPGDMLYLPASWFHEVTSSSASSGGSDVHIAFNYWFHPPDNLEDFDHPYLDRNIWQAKRHLVGEAIDQLYATNKKNEKRPAEDDSPSQKKTCQ
Protein: ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (CAZ-associated structural protein 2) (CAST2) (Rab6-interacting protein 2) (Q99MI1)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8IUD2}. Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Presynaptic active zone {ECO:0000269|PubMed:14723704}. Cell projection, podosome {ECO:0000269|PubMed:23525008}. Note=Recruited on Golgi membranes by RAB6A in a GTP-dependent manner. Localized to the cortex of myotube podosomes (PubMed:23525008). {ECO:0000269|PubMed:23525008}.
Interaction partners:
- Regulating synaptic membrane exocytosis protein 1
- Ppfia1 protein,-interacting protein
- NF-kappa-B essential modulator
- Regulating synaptic membrane exocytosis protein 2
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Pleckstrin homology-like domain family B member 2
- Protein unc-13 homolog A
- Protein bassoon
- Mitogen-activated protein kinase kinase kinase 7
Sequence:
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGAETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENNMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSSEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKDAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLSEKEASLLDIKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLEARASPEMSDRIQQLEREISRYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDSLSDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFRSSRSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTALCHDRDPLILRGLTPPASYNADGEQAAWENELQQMTQEQLQNELEKVEGDNAELQEFANTILQQIADHCPDILEQVVNALEESS
Protein: Isopimaradiene synthase, chloroplastic (EC 4.2.3.-) (Terpene synthase TPS-Iso) (PsTPS-Iso) (F2XF92)
Organism: Picea sitchensis (Sitka spruce) (Pinus sitchensis)
Function: Terpene synthase (TPS) involved in the biosynthesis of diterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (+)-copalyl diphosphate ((+)-CPP) to isopimaradiene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALPSSSLSSRIPTGPHPLTHTQCIPHFSTTINAGISAAKPRSFYLRWGKDSQPKNLGSNKIIACVGEGTTSLPYQSAEKTDSLSAPTLVKREFPPGFWKDHVIDSLTSSHKVSAAEEKRIETLISDIKNIFRSMGYGETNPSAYDTAWVARIPAVDGSEQPEFPETLEWILQNQLKDGSWGEGFYFLAYDRILATLACMITLTLWRTGETQIRKGIEFFKTQAGKIEDEADSHRPSGFEIVFPAMLKEAKVLGLDLPYELSFIKQIIEKREAKLERLPTNILYALPTTLLYSLEGLQEIVDWQKIIKLQSKDGSFLTSPASTAAVFMRTGNKKCLEFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDRHFKEEIKDALDYVYSHWDERGIGWARENPVPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQTQRGVTDMLNVNRCSHVAFPGETIMQEAKLCTERYLRNALEDVGAFDKWALKKNIRGEVEYALKYPWHRSMPRLEARSYIEHYGPNDVWLGKTMYMMPYISNEKYLELAKLDFNHVQSLHQKELRDLRRWWKSSGFSDLKFTRERVTEIYFSAASFIFEPEFATCRYVYTKMSIFTVILDDLYDAHGTLDNLNLFSEGVKRWDLSLVDRMPQDMKICFTVLYNTVNEIAVEGRKRQGRDVLGYIRNVLEILLAAHTKEAEWSATRYVPSFDEYIENASVSISLGTVVLISALFTGEILTDDVLSKIGRGSRFLQLMDLTGRLVNDTKTYQAERGQGEVASAVQCYMKDHPEISEEEALKHVYTVMENALDELNREFVNNREVPDSCRRLVFETARIMQWFYMEGDGFTVSHEMEIKEHVKNCLFQPVA
Protein: Cytochrome P450 93B16 (EC 1.14.19.76) (Flavone synthase II) (GmFNSII) (E9KBR8)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Functions as flavone synthase II (FNSII) that catalyzes the direct conversion of flavanones to flavones. In vitro, can convert liquiritigenin, naringenin and eriodictyol to 7,4'-dihydroxyflavone, apigenin and luteolin, respectively.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Naringenin,2-oxoglutarate 3-dioxygenase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Flavanone 4-reductase
- Dihydroflavonol-4-reductase DFR1
- Cytochrome P450 71D9
- Flavonoid 3'-monooxygenase
- flavonoid 3',5'-hydroxylase
- Flavonoid 3'-monooxygenase
- Dihydroflavonol 4-reductase
- Flavonoid 3'-monooxygenase
Sequence:
MISESLLLVFLIVFISASLLKLLFVRENKPKAHLKNPPSPPAIPIIGHLHLLKPLIHHSFRDLSLRYGPLLSLRIGSVKFIVASTPSLAQEFLKTNELTYSSRKMNMAINMVTYHNATFAFAPYDTYWKFMKKLSTTELLGNKTLGHFLPIRTREVHDIIQFLFHKSKAQESVNLTEALLSLSNNVISQMMLSIKSSGTDSQAEQARTLVREVTQIFGEFNVSDFLGFCKNLDLQGFRKRALDIHKRYDALLEKIISDREELRRKSKVDGCEDGDDEKVKDFLDILLDVAEQKECEVQLTRNHVKSLILDYFTAATDTTAISVEWTIAELFNNPKVLKKAQEEVDRVTGNTQLVCEADIPNLPYIHAIIKETMRLHPPIPMIMRKGIEDCVVNGNMIPKGSIVCVNIWAMGRDPNIWKNPLEFKPERFLEGEGSAIDTKGHHFELLPFGSGRRGCPGMPLAMRELPTIIGALIQCFEWKMLGSQGEILDHGRSLISMDERPGLTAPRANDLIGIPVARLNPTPFRQM
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q383Y4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- H/ACA ribonucleoprotein complex subunit 2
- Sm protein F
- Nop domain-containing protein
- Trans-splicing factor, putative
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- 50S ribosomal protein L13, putative
- Acyl carrier protein
- AMP-dependent synthetase/ligase domain-containing protein
Sequence:
MRISERAFMDIAIGTKAPRRIVFKLFPRKCPSAVKNFIELCSGNVSTDTYESGNRDKLISESALPQLTYKNSTFHRVEKGYLIQGGDIVTGRGTEQLSIYGGTFSAPEEVRASVFDKPGLVGTASSSPNAHGSQFFILTAKEANHLNGTCICFGQVADGLDVVQEIEQVPIDPSGFPSLKVSIVDCGVLE
Protein: Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3) (P81062)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Nuclear receptor subfamily 4 group A member 2
- Forkhead box protein E3
- Hepatocyte nuclear factor 3-beta
- Tyrosine 3-monooxygenase
- Synaptic vesicular amine transporter
- G protein-activated inward rectifier potassium channel 2
- Neurogenin 2
- Aromatic-L-amino-acid decarboxylase
Sequence:
MEFGLLGEAEARSPALSLSDAGTPHPPLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGGFAAPLGGLVPPYEEVYPGYTYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGAPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVPGPPPAANLSPCQYAVERPV
Protein: Photosynthetic apparatus regulatory protein RegA-2 (D5AQX9)
Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Interaction partners:
- histidine kinase
- histidine kinase
- Photosynthetic apparatus regulatory protein RegA
- Peptide chain release factor 2
Sequence:
MTDPRCLLIVEDDPHLAETLASAFARRGHAVHTAPREEMAITLARRLRPSHAIVDLKLAEGSGLGVVKALAALDPPPAIVVLTGFAAVATAVEAIKLGATQYLAKPATVREIEAAFAHRAGMAMPEIETPQVGVKAQEWELIQRTLAETGFNVSETARRLGMHRRTLARKLAARKAAGEDLGGMIDFED
Protein: Global nitrogen regulator NrpR (Nitrogen regulatory protein R) (Q6LZL7)
Organism: Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
Function: Transcriptional repressor of nitrogen fixation and assimilation genes. Binds to two tandem operators in the glnA and nif promoters, thereby blocking transcription of the genes.
Interaction partners:
- Glutamine synthetase
- Nitrogenase iron protein
- 2-hydroxyglutaryl-CoA dehydratase
- Ribosomal RNA large subunit methyltransferase E
- Pyridoxal 5'-phosphate synthase subunit PdxT
- Nitrogenase iron protein
Sequence:
MDSNIDVEILSILSEASAPVGAKIIADSLKDRGYDIGERAVRYHLKVLDENSLTKKLGYSGREITEKGIEELEKANISFRIGSVFSQVIEKLYLSDFPSKVLINTAKFEGDYKTIKEMVLRSFEAGYSVGDYLNIKKKGNTVSVETLCSITFDNFLLKNGIIPTPEYGGIVKFEDYEPVNFEGVIDFKSSSIDPLVAFIMQGKTDVIGVIENGEGLVPANFRVIPKSSEKQFETILKKDMLNSVLAYGTENVLGMNLNPEQIGVVLVGGLTPLCVPHESGYTADISAATQLKDISSMEKKTKGFLEAKKKKGKFKVTPVLSKMLSKMQTINYDIEDKKGNVVVNTAKIPIEYKEEAINALKDSYENKLAISDRLKVECDDKFLNAYTICSLTVDGVFLKNKIPVIPYYGGILEVKADKKRFIEAIDYEGTSLDPHEVFFNKADGKNYILAGIRKVPMSASEKLIELNEKLGWNSIIEIGRPNNDICGVRVEKCMFGITTIGGTNPFANIRKNNIPVEMKTLHKSIDYSELTHYDDI
Protein: RH70774p (Q8MYS8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVEDNCSMHHLERELDLELEIDMAMECAPIGRTIKSALLRAQSEARVIVGLSAAINVLSKSPEGSLFCLMAQPKDGDSATHMHEVLLEAFCYENDIYVIKVDDATKLSRILGQDSVESCCLVQKVWADAPEEQLTKAENQLVDYCEAHWDAPQQPIVQLPAV