wanglab/gogpt-training-data huggingface dataset:
Protein: Mismatch repair protein PMS1, putative (Q38D26)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mismatch repair protein MLH1
- DNA mismatch repair protein, putative
- Mismatch repair protein MSH8, putative
- Exonuclease, putative
- Proliferating cell nuclear antigen
- Mismatch repair protein MSH3, putative
- Mismatch repair protein MSH5, putative
- Mismatch repair protein, putative
- MutL C-terminal dimerisation domain-containing protein
- DNA repair protein, putative
Sequence:
MITLLDEGSSRKLSAGQVITNLSSVVKELVENSLDAGARTVAIRVEDSGAGNITVEDDGSGMDLSYLLDSEGRLKEDASLPLLASRATTKRRGGDSGLSSQAAQTLGFRGEALHSLAHLSELSICTMSESTRPTALLIAYDSNSRRTTVKVTSERRDVGTTVVVSKLFAALPVRHKDFVRGRKKQLLAATLLMKQYALSHPHVRLLMTHRAGPDSAPVTLVSLTGTGDPQRALAEAYGGRVIANMERVEWELTFGTITGYVSKGNAGRLSSDMQVFALDGRLVDLPMMAKAVNDAYAESLPNAAQRTFPAFFLHVSSGESLPYDVNLVPDKRKVLISDEERHAGEVRTCGLRTFQASTDGIDLPVRNEGGWRHVPERRNTQETMPTQTPLSATSIAQFIYQRRETSQGDNLIDNAAVAQVQPSVCLSQLLSGSSPIGRTSSPDATASPTSTTNRAPSERSAGSVESVLEYPLTFEPTQKRQRLESSAEEGNTGDTDGSSWGEEDPRELGPEEMMGTDDAVVNYVTDDTNQQRPGPPRSSVRFPPFSVLAEMPLVHSLGEWAAPSQPSDGGGVRKFSRLQKQTEEELTLYLGKESFKNMVVHGQFNHGFIVTSLDDNIFVIDQHAADEKGNYEHLMSHYVARPQPLFSPVPVSMEPQAVDLAVDHAEELRQHGFIVQRSDDTNKLLVLSVPVIPYEVVDPQNVVELIRQLVHYNTISKPMRCVWHSMATKACRSSIMVGTMLSEKKMRSVVDRMGELEQPWNCPHGRPTVRHVSKISSLVSLMTKSRRA
Protein: RRM domain-containing protein (D5MCR5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNASSAPQQQQQQQQPQQGQAPQQQQQGPPQHQYQQQRPFHGTNLYIRGLMPNTNDDLLREMCSKYGNIASTKAIMDKATNNCKGYGFVDFESPQAAAAAVDGLNTEGVQAQMAKLQQQEQDPTNLYIANLPLDFTEQMLETELNKFGMVISTRILRTPDNQSRGVGFARMDSKEKCEVIISALNGGRFDTMSKEGPALLIKQADTGRKSKHSMNNPEMLQRMQYPQVYQSYYGYHPAAVYQQHYDVNSLASQMGGMHVGGGNPQANGGGDMYGAHMYGQNAGGQGGQGVGQGGQADESTINGQDNVFTPLLLSSLNLFSLSILSNQSSLQKKTQCAAARAAINTHVHIVSPLPDPQNLLLFLNPKTIVPF
Protein: Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8-sialyltransferase III) (Ganglioside GD3 synthase ST8SIA3) (EC 2.4.3.8) (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) (Sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase) (hST8Sia III) (Sialyltransferase 8C) (SIAT8-C) (Sialyltransferase St8Sia III) (ST8SiaIII) (O43173)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:10766765}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Neural cell adhesion molecule 1
Sequence:
MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA
Protein: Heat shock protein 90 homolog (P41887)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Interacts with the wee1 protein kinase; which requires swo1 for its activation.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Hsp90 co-chaperone Cdc37
- Heat shock protein sti1 homolog
- Uncharacterized protein C1711.08
- 40 kDa peptidyl-prolyl cis-trans isomerase
- Glucose-insensitive transcription protein 7
- Protein wos2
- Heat shock protein 104
- Heat shock factor protein
- Probable heat shock protein ssa2
- Probable heat shock protein ssa1
Sequence:
MSNTETFKFEAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQSLSDPHALDAEKDLFIRITPDKENKILSIRDTGIGMTKNDLINNLGVIAKSGTKQFMEAAASGADISMIGQFGVGFYSAYLVADKVQVVSKHNDDEQYIWESSAGGSFTVTLDTDGPRLLRGTEIRLFMKEDQLQYLEEKTIKDTVKKHSEFISYPIQLVVTREVEKEVPEEEETEEVKNEEDDKAPKIEEVDDESEKKEKKTKKVKETTTETEELNKTKPIWTRNPSEVTKEEYASFYKSLTNDWEDHLAVKHFSVEGQLEFRAILFVPRRAPMDLFEAKRKKNNIKLYVRRVFITDDCEELIPEWLGFIKGVVDSEDLPLNLSREMLQQNKIMKVIRKNLVRRCLDMFNEIAEDKENFKTFYDAFSKNLKLGIHEDAANRPALAKLLRYNSLNSPDDLISLEDYITKMPEHQKNIYFITGESKQAVENSPFLEIFRAKKFDVLFMVDPIDEYAVTQLKEFEGKKLVNITKDGLELEETDEEKAAREKLEKEYEEFAKQLKTILGDKVEKVVVSNKIVGSPCLLTTGQYGWSANMERIMKAQALRDTSMSAYMSSRKTFEINPKSPIIAELKKKVEENGAEDRSVKDLATILYETALLSSGFTLDDPSAYAQRINRLISLGLSIDEEEEAPIEEISTESVAAENNAESKMEEVD
Protein: AW551984 protein (Q6P8K4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVRSGGLLTSIRDPVALKSIAVTLSINDFVAGVSATLNYENEEKSPLEAFFVFPMDEDSAVYSFEAFVDGKKIVAELQDKYQAHKRYEEALSGGYQAYLLEEDKCSRDVFCCNVGNLQPGSKVSLTLRYVQELPLEDDGALRYVLPAILNPRYHLSDGREDSNLDMKTPIVPLEELPYTLSMVATISSQLGISTIQSNCPLNPIEYTGEFVFLMDRSRSMNSPMSSKDKSQLRIDAAKETLILLLKSLPMGCYFNIYGFGATHEEFFPDSVMYNQETMQIAVKKVKRLLADLGGTELLTPLRKIFRKPPIPGHPLQVFVFTDGEVVETFSVIREVMFQSKKHRCFSFGIGEGASTSLIKNLARVSGGTAEFITGNDRMQSKALRSLRRSLQSVVEDVSLSWNLPPKMFAPMLSPEQTSIFRGQRLIIYSLLIGKIPKEEATGEVCLSYKLHGKSYEEKVTFSLQPKPDDNLTIHRLAAKSMIQSKDFGFKETSLMYKRDVLDISLESGVMSSFTAFVAINKELNEPIQGPLVHRDIPRPILLGAGPNRPSDGGYPKTLFCASAPVTLPPWLKGSGKCVATILMPNGTPQQRQNSQKKKCVVHTDTRPELPHLAKYDSYPQGSKEHSIAQLIYLQNADGSWDMNEDLAKILSTSLEDITAACPTEVLEPSAWATMLAVIWLHANGKELKDEWELLERKAVVWLHNNSALTLIPPLHSPWFQQAYTYCQQALEDIFEPLDLQVIRVMSRRMAFFPASCHTLHLIS
Protein: FI18818p1 (Focal adhesion kinase, isoform A (EC 2.7.10.-)) (Focal adhesion kinase, isoform B) (Focal adhesion kinase, isoform C) (Focal adhesion kinase, isoform G) (Q0E917)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNTAGATSQPPPTKNEINSEEYLIHVHMPNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRQRSCSIPQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPPNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQRYQHLFPPSATKETSCSSSFESTSGSIVAEPVNDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNPKASIDLSGGGSLQRGMSLGLDTTRSTNEPLRIVEETLGSPGEHMYCNTSALHGHA
Protein: WEB family protein At5g16730, chloroplastic (Q9LFE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- WEB family protein At5g55860
- At1g10140
- B3 domain-containing protein REM1
- Plasma membrane-associated cation-binding protein 1
- Syntaxin-122
Sequence:
MASKTKTSLSETTTTTTPTGKSSPATPRIAKRTVNKSETSNNNSPSTTTPHSRLSLDRSSPNSKSSVERRSPKLPTPPEKSQARVAAVKGTESPQTTTRLSQIKEDLKKANERISSLEKDKAKALDELKQAKKEAEQVTLKLDDALKAQKHVEENSEIEKFQAVEAGIEAVQNNEEELKKELETVKNQHASDSAALVAVRQELEKINEELAAAFDAKSKALSQAEDASKTAEIHAEKVDILSSELTRLKALLDSTREKTAISDNEMVAKLEDEIVVLKRDLESARGFEAEVKEKEMIVEKLNVDLEAAKMAESNAHSLSNEWQSKAKELEEQLEEANKLERSASVSLESVMKQLEGSNDKLHDTETEITDLKERIVTLETTVAKQKEDLEVSEQRLGSVEEEVSKNEKEVEKLKSELETVKEEKNRALKKEQDATSRVQRLSEEKSKLLSDLESSKEEEEKSKKAMESLASALHEVSSEGRELKEKLLSQGDHEYETQIDDLKLVIKATNEKYENMLDEARHEIDVLVSAVEQTKKHFESSKKDWEMKEANLVNYVKKMEEDVASMGKEMNRLDNLLKRTEEEADAAWKKEAQTKDSLKEVEEEIVYLQETLGEAKAESMKLKENLLDKETEFQNVIHENEDLKAKEDVSLKKIEELSKLLEEAILAKKQPEEENGELSESEKDYDLLPKVVEFSSENGHRSVEEKSAKVETLDHEPPQEQISNGNSNGNGMEEKEVNGKPEVETEKKEKKDESQDDDKDDSVEVIFKMWESCQIEKKEAFPDKKSELESQEEEEDSSKIDESDKTSTENIDETGNALTAEDQLTMEKKIKKKKTLLGKVGNLLKKKAPVNQK
Protein: Vps51p (A0A1D8PQ10)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Vps53p
- Vps52p
- t-SNARE affecting a late Golgi compartment protein 1
- chitin deacetylase
- Arf family GTPase
- Vacuolar protein sorting-associated protein 54
Sequence:
MTETSILSYKKPTSNKNSFPVPGSAPSTPILSHSGSPAPPTIQSPVSIDSPRSSTSTTTNVGASTRKVSARRKALQDFYHLNSNSDNATTDGNDTTHEGISKISNLNDIDNLIKTAPIEEILKIRNDLSAKLNSSNQTKKSIIYDNYYELIKLSNTLSDLSTSKPRKKSVSTGLKIFADDEDNGEDSGDKNLTELTKEGYVDQVLKELSEFASKEAPVFNGTFNDVLGKLKEQDESDNSSMIVLNDDKPTEKEESSEDIEKQISHINYILNLPLKTNINDTEREQAIEYIDKVILDNPDNEILSLQLGKIKHDITT
Protein: DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4) (Q2HRD0)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).
Subcellular location: Host nucleus {ECO:0000305}. Note=The protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs. {ECO:0000250}.
Interaction partners:
Sequence:
MDFFNPFIDPTRGGPRNTVRQPTPSQSPTVPSETRVCRLIPACFQTPGRPGVVAVDTTFPPTYFQGPKRGEVFAGETGSIWKTRRGQARNAPMSHLIFHVYDIVETTYTADRCEDVPFSFQTDIIPSGTVLKLLGRTLDGASVCVNVFRQRCYFYTLAPQGVNLTHVLQQALQAGFGRASCGFSTEPVRKKILRAYDTQQYAVQKITLSSSPMMRTLSDRLTTCGCEVFESNVDAIRRFVLDHGFSTFGWYECSNPAPRTQARDSWTELEFDCSWEDLKFIPERTEWPPYTILSFDIECMGEKGFPNATQDEDMIIQISCVLHTVGNDKPYTRMLLGLGTCDPLPGVEVFEFPSEYDMLAAFLSMLRDYNVEFITGYNIANFDLPYIIARATQVYDFKLQDFTKIKTGSVFEVHQPRGGSDGGNFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKQCLGRQKDDISYKDIPPLFKSGPDGRAKVGNYCVIDSVLVMDLLLRFQTHVEISEIAKLAKIPTRRVLTDGQQIRVFSCLLEAAATEGYILPVPKGDAVSGYQGATVISPSPGFYDDPVLVVDFASLYPSIIQAHNLCYSTLIPGDSLHLHPHLSPDDYETFVLSGGPVHFVKKHKRESLLAKLLTVWLAKRKEIRKTLASCTDPALKTILDKQQLAIKVTCNAVYGFTGVASGILPCLNIAETVTLQGRKMLERSQAFVEAISPERLAGLLRRPVDVSPDARFKVIYGDTDSLFICCMGFNMDSVSDFAEELASITTNTLFRSPIKLEAEKIFKCLLLLTKKRYVGVLSDDKVLMKGVDLIRKTACRFVQEKSSQVLDLILREPSVKAAAKLISGQATDWVYREGLPEGFVKIIQVLNASHRELCERSVPVDKLTFTTELSRPLADYKTQNLPHLTVYQKLQARQEELPQIHDRIPYVFVDAPGSLRSELAEHPEYVKQHGLRVAVDLYFDKLVHAVANIIQCLFQNNTSATVAILYNFLDIPVTFPTP
Protein: Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1) (O95571)
Organism: Homo sapiens (Human)
Function: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12398897}. Nucleus {ECO:0000269|PubMed:12398897}. Mitochondrion matrix {ECO:0000269|PubMed:14732903}.
Interaction partners:
- Sulfide:quinone oxidoreductase, mitochondrial
- Sulfite oxidase, mitochondrial
- Thiosulfate sulfurtransferase
- 3-mercaptopyruvate sulfurtransferase
- Leucine-rich PPR motif-containing protein, mitochondrial
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA
Protein: FI16703p1 (Heterochromatin protein 4, isoform B) (Q9VSC4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSPKTKKMIVKIPRHPYFNVQGERSVEREVEYQVRKCRVNLERIKSSTSPNSRPFPLKPKPKRCIVRVARLPDVERSEISVTPASSIMNSDIDESRCQVF
Protein: Ras-related protein Rab-3B (EC 3.6.5.2) (Q9CZT8)
Organism: Mus musculus (Mouse)
Function: Protein transport. Probably involved in vesicular traffic (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:18396146}. Note=Colocalizes with GAS8/DRC4 in the Golgi apparatus. {ECO:0000269|PubMed:18396146}.
Interaction partners:
- Polymeric immunoglobulin receptor
- Regulating synaptic membrane exocytosis protein 2
- Rab effector Noc2
Sequence:
MASVTDGKTGIKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGRLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSMDTDPSVLGASKTTRLSDTPPLLQQNCSC
Protein: ESX-1 secretion system protein EccE1 (ESX conserved component E1) (Type VII secretion system protein EccE1) (T7SS protein EccE1) (P9WJE9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mycosin-1
- ESX-1 secretion system ATPase EccB1
- ESX-1 secretion-associated protein EspK
- ESX-1 secretion system protein EccD1
- ESX-1 secretion system protein EccCa1
- ESX-1 secretion-associated protein EspB
- ESX-1 secretion-associated protein EspL
- 6 kDa early secretory antigenic target
- ESX-1 secretion system protein EccCb1
- ESX-2 secretion system protein EccA2
Sequence:
MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGWVAAVYAWLRRRRRPPDSSSEPVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVDGQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTAAPDVVSLYQQVIGTDPAPANRRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYDHATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLLTTADKPKTPRGFARLFGGQRPALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDDVDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLIGAHIGQEVKVAWPNATTYLGPHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK
Protein: Putative peroxiredoxin Rv2521 (EC 1.11.1.24) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin Rv2521) (P9WIE1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Interaction partners:
- Possible conserved membrane protein
- Thioredoxin
Sequence:
MTKTTRLTPGDKAPAFTLPDADGNNVSLADYRGRRVIVYFYPAASTPGCTKQACDFRDNLGDFTTAGLNVVGISPDKPEKLATFRDAQGLTFPLLSDPDREVLTAWGAYGEKQMYGKTVQGVIRSTFVVDEDGKIVVAQYNVKATGHVAKLRRDLSV
Protein: Citrate synthase (A0A060VYW9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
- malate synthase
- Malate dehydrogenase
- Malate dehydrogenase
- Cytoplasmic aconitate hydratase
- Aconitate hydratase, mitochondrial
- Aconitate hydratase, mitochondrial
- Aconitate hydratase, mitochondrial
- Aconitate hydratase, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Sequence:
MSFLTTGISRLAPRLLNSKNVTCILVASRHASSSTNLKDVLTDLIPKEQSRIKSFKQQYGKTNIGSITVDMVYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQQLLPKAPGGQEPLPEGLFWLLVTGQVPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQFSAAITALNSESSFARAYSEGVNKAKYWEFIYEDSMDLIAKLPCVAAKIYRNLYREGSSIGAIDSNLDWSANFANMLGYSDSAEFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAALNGLAGPLHGLANQEVLVWLTALQKEMGGEVSDEKMRDYIWNTLKSGRVVPGYGHAVLRKTDPRYQCQQEFAFKHLPNDPMFKLVHQLYKIVPPVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMTLVGANKSG
Protein: WHI2-like protein P4H10.16c (Q9P7D3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized ABC transporter ATP-binding protein C29A3.09c
- Alcohol dehydrogenase 4
Sequence:
MSVITQAQEIPTVAANPDFNYEGDPIIIQLCDRDTVFELSRDQLLGLPESILMCLFPRGLLLDYEIQECQLTQRPLIFQTADFDPSLLQYILNYFQMAENRTANDEIALSPPPPSFPGKCGIILLKEDIEFFILPPISPTTNIAIEVSPNDLLKLKQRVAQRLLQQKKIFDCLHLENSTSEGSAEKNLVRMLCYSGFHEDDEWKRRIQEPHRACITSVTLTNLDFSADQGPVSDPEYFPVYHKLLLFWQKPARKCWWDSSTSITYNGIEFATWVRRVWTLELAVLGANTYETAAV
Protein: Fibroblast growth factor (FGF) (Q8R5L5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor
- Klotho
- Pro-epidermal growth factor
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- Platelet-derived growth factor receptor alpha
- Vascular endothelial growth factor receptor 1
Sequence:
MALGQRLFITMSRGAGRVQGTLQALVFLGVLVGMVVPSPAGARANGTLLDSRGWGTLLSRSRAGLAGEISGVNWESGYLVGIKRQRRLYCNVGIGFHLQVPPDGRISGTHEENPYSLLEISTVERGVVSLFGVKSALFIAMNSKGRLYTTPSFQDECKFRETLLPNNYNAYESDLYRGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI
Protein: Vivid PAS protein VVD (Q9C3Y6)
Organism: Neurospora crassa
Interaction partners:
Sequence:
MSHTVNSSTMNPWEVEAYQQYHYDPRTAPTANPLFFHTLYAPGGYDIMGYLIQIMNRPNPQVELGPVDTSCALILCDLKQKDTPIVYASEAFLYMTGYSNAEVLGRNCRFLQSPDGMVKPKSTRKYVDSNTINTMRKAIDRNAEVQVEVVNFKKNGQRFVNFLTMIPVRDETGEYRYSMGFQCETE
Protein: Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (P05181)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Microsome membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000250|UniProtKB:P05182}.
Interaction partners:
- Cytochrome P450 3A4)
- All-trans-retinol dehydrogenase [NAD
- Cytochrome P450 1A2
- UDP-glucuronosyltransferase 1A6
- Glutathione S-transferase P
- Glutathione S-transferase Mu 1
- Epoxide hydrolase 1
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A7
Sequence:
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS
Protein: Probable protein disulfide-isomerase A4 (EC 5.3.4.1) (ERp-72 homolog) (P34329)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Endoplasmic reticulum oxidoreductin-1
- Heat shock 70 kDa protein C
- Prolyl 4-hydroxylase subunit alpha-2
- Calreticulin
- Sulfhydryl oxidase
- Endoplasmic reticulum chaperone BiP homolog
- Endoplasmin homolog
- Protein disulfide-isomerase A6 homolog
- Prolyl 4-hydroxylase subunit alpha-1
Sequence:
MMFDRRFFALVVLLCVSAVRSTEDASDDELNYEMDEGVVVLTDKNFDAFLKKNPSVLVKFYAPWCGHCKHLAPEYEKASSKVSIPLAKVDATVETELGKRFEIQGYPTLKFWKDGKGPNDYDGGRDEAGIVEWVESRVDPNYKPPPEEVVTLTTENFDDFISNNELVLVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTMKIIRNGRRFDYNGPREAAGIIKYMTDQSKPAAKKLPKLKDVERFMSKDDVTIIGFFATEDSTAFEAFSDSAEMLREEFKTMGHTSDPAAFKKWDAKPNDIIIFYPSLFHSKFEPKSRTYNKAAATSEDLLAFFREHSAPLVGKMTKKNAATRYTKKPLVVVYYNADFSVQYREGSEYWRSKVLNIAQKYQKDKYKFAVADEEEFAKELEELGLGDSGLEHNVVVFGYDGKKYPMNPDEFDGELDENLEAFMKQISSGKAKAHVKSAPAPKDDKGPVKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPNVVLAKMDATINDAPSQFAVEGFPTIYFAPAGKKSEPIKYSGNRDLEDLKKFMTKHGVKSFQKKDEL
Protein: Exoribonuclease II, mitochondrial (RNase II) (Ribonuclease II) (EC 3.1.13.1) (Deletion of SUV3 suppressor 1) (Mitochondrial biogenesis protein MSU1) (P39112)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for mitochondrial biogenesis.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:14576278}.
Interaction partners:
- ATP-dependent RNA helicase SUV3, mitochondrial
- Exosome complex exonuclease RRP6
- Exosome complex component RRP45
- Exosome complex component CSL4
- Exosome complex component RRP42
- Exosome complex component RRP43
- Exosome complex component SKI6
- Exosome complex component RRP40
- Exosome complex component RRP4
- Exosome complex component RRP46
Sequence:
MVVRRKVHVLLIARSFHSYTPCFRVTTRGKRQRSKSKQQAKVELDHTRELDNDQATETVVDRSVGPEKDIESINKDFLQRTKGLEPDIELKQLPQIKQEFNQRYKDRYVKPSEDWYVNSWRSLTKPKIPLYKLINSDFQLITKLKAPNPMEFQPVQLMESPLNVGDFVLLKMRPNELAMCVSLPSSTMDPRYTFVTIDGTMCFATKNRVLLRIPHKLPAGIHSLIQPESHHKHLPIGTVKNFSNQTNILPIVARQLITSRYPAQISKLAWKDLPITTKKLQLLHRSLQNYMGPWQIPFFTLVGLVQKLDLNKALDDKNGINYLTSLVNNYHTVNDIPINSPTFVSTYWAIMQQQESNLWGEIHLNTALLSPISVTIIPLKSQHLYYAQVIEKLEANSYREVNKFVKLVNERKYRDISALYPSVIQLLKDFAAGNFHNNGIIVALISKIFRKIERYKDCDITRDICQDLINEITPNSIPNPLLLNMDLALPASSKLVKWQQKLYDLTNIEELQWKKSGTDDDRYDFGDLRVFCIDSETAHEIDDGVSVKNYGRDGLYTLYIHIADPTSMFPESTNVDIEGISTDILNVALKRSFTTYLPDTVVPMLPQSICHLSDLGKQGQRTKTISFSVDVKITSKCSGKSIEIMYDSFKIRKGIVSNFPKATYEDVDRILGTPNSEASPVKKDLESLSMISKLLREQRIKNSNAVIFGEGFNKGLVMLNADSEGELTEVTFSDQEETLSTILVSEMMILANTLTGRYFAENKIGGVFRCYKQLPLGEVAQQQYDSMITSTKKGIFPKLKDIVKLSSLLNSSFYTGRPFRHEMIGAKQYLTVTSPLRRFPDLINHLQIHRHLQKKPLCFNQTQIDSLIWPIQSRADILKRASRNSSTYWTLNYLKKLTKLEPERTFDVMVTSVPQNGFTGCVFPDLSFARGTLKLHPSSMHYPMIGDIVKNCKISKIDCLEGMLELEKL