wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2(14k)) (Ubiquitin-protein ligase B) (P63149)
Organism: Rattus norvegicus (Rat)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15946855}. Nucleus {ECO:0000269|PubMed:15946855}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Interaction partners:
- E3 ubiquitin-protein ligase RAD18
- E3 ubiquitin protein ligase
- E3 ubiquitin-protein ligase BRE1B
- Ubiquitin conjugating enzyme E2 V1 like 1
- E3 ubiquitin-protein ligase
- Ubiquitin-conjugating enzyme E2 variant 2
- Polyubiquitin-C
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-conjugating enzyme E2 N
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS
Protein: 2-oxoacid:ferredoxin oxidoreductase subunit alpha (OFOR) (EC 1.2.7.11) (P72578)
Organism: Sulfolobus sp
Function: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11683888, ECO:0000269|PubMed:8902625}.
Interaction partners:
Sequence:
MRLSWVIGGAQGTGIDTAANIFGNAVASAGYYIYGNREYYSNIKGGHSYFSLTISDKRVRSNTQKIDILVSFDAETVFQHFYDVKDILIYNKAVETTKIDAVQSMEPELAERIKDFLTKQGYETTVKGALEYASKNNVTLIPVNYDEIAKKVADEMKVPLSVTERVKNIVGITISYKLLGLDVNYLIEAINSTFKQDLYRKMNELAVKDSYDIVESRYNLKPSSKERRRFWLDGNTAVAIGKIYGGVRFQSYYPITPASDESVYIEAHQDVLMEDPITGDKKKGTIVVVQAEDELAAINMAIGAALTGVRAATATSGPGFSLMVEGLGWAGMNEVPVVITYYIRGGPSTGLPTRTAQSDLIFPIFAGHGEFPKIVLASGDHAEAFKDAIWALNLAEKYQTPVIHLVEKTLANSYSTIPYEELELDKLKAERGKIVESGDISYKRFKFTEDGISPRAFLGKATMYYTGDEHNEEGHISEDVVNRTMMYEKRMKKLEVADKEIPEESRVKIYGDLNSRNLIITWGSPTGVLRDILEESNFDFTLLQIRMFSPFPKNLVSKLMEGRDKIITVEGNYLAQTSLLVKMYTGKDVTNSILKWNGRPFLRDELEEALIKVIKDGEKRVVLNGGIYTSME
Protein: SWR1-complex protein 5 (O74897)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- SWR complex protein 2
- SWR1-complex protein 4
- RuvB-like helicase 1
- SWR1 complex subunit vps71
- Protein AF-9 homolog
- Histone H2A.Z
- Helicase swr1
- RuvB-like helicase 2
- Actin-like protein arp6
- Actin
Sequence:
MTEKLIDFGLEQEEEDTEFVPGDSTDTESSFSDADSSEEEFVEEKEASQVQSTKSKIATSESEDVTLKNIAKKNKRERNDKLIPQQSNESEAIEKPVQSTTEVELKTNELAESNSSVAVEGDENSYAETPKKKHSLIRKRRKSPLDSSSAQKVLKKNKLNTLEQAQQNWSKYIKEQDIQDELRIANKDGYVERQEFLAKTRAAHEEKIREMKKLP
Protein: Diol dehydratase-reactivating factor small subunit (DDR small subunit) (Diol dehydratase-reactivase small subunit) (Diol dehydratase-reactivating factor beta subunit) (DDR beta subunit) (DDRB) (O68196)
Organism: Klebsiella michiganensis (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686 / BUCSAV 143 / CCM 1901)
Function: Small subunit of the diol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent diol dehydratase (DD, pddA, pddB, pddC). DDR acts as a chaperone, reactivates inactivated DD holoenzyme in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one. Reactivation takes place in two steps: ADP-dependent cobalamin release, and ATP-dependent dissociation of the DD apoenzyme-DDR complex. DDR has weak ATPase activity which is required for DD reactivation. Activates glycerol-inactivated, O2-inactivated holoenzyme and inactivated enzyme-cyanocobalamin complex. Also reactivates glycerol-inactivated hologlycerol dehydratase, a DD isozyme.
Interaction partners:
Sequence:
MNGNHSAPAIAIAVIDGCDGLWREVLLGIEEEGIPFRLQHHPAGEVVDSAWQAARSSPLLVGIACDRHMLVVHYKNLPASAPLFTLMHHQDSQAHRNTGNNAARLVKGIPFRDLNSEATGEQQDE
Protein: Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa) (P18075)
Organism: Homo sapiens (Human)
Function: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors.
Subcellular location: Secreted.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Noggin
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-2A
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1A
- Activin receptor type-2B
- Chordin
- Follistatin
- Bone morphogenetic protein 2
Sequence:
MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
Protein: Neuroblastoma-amplified sequence protein (F4KH34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MESPGRKVLYEIRHHASLPYVPRYPPLPQADGTNSKGGLRSLVSIKGVSQLKEKWSEYWNPKKTNKPVSLFISPRGELVAVTSGNHVTILRKDDDYRKPCGNFTSSISGSFTSGVWSEKHDVLGLVDDSETLFFIRANGEEISQVTKRNLKVSAPVLGLMEDDSDLQPSCLCSFSILTSDGRIHHVEISREPSASAFSKHASNSVSKQFPNHVFCFDYHPDLSFLLIVGSVAGISSSGSSGSSCISLWRKCQNLGLELLSTTKFDGVYCENKDDQLAYPKTLISPQGSHVASLDSNGCVHIFQLDKARLTLSCCPSEDSSDSLKPDKSLQSWKESLRNVVDFTWWSDHALAILKRSGNISIFDISRCVIVQEDATIYSMPVVERVQKYEGHIFLLESSTQEAKSALANVDRDASEFHHTSEHSMLWRLISFTEKTIPEMYKILVEKCQYQEALDFSDSHGLDRDEVFKSRWLKSEKGVSDVSTILSKIKDKAFVLSECLDRIGPTEDSMKALLAHGLYLTNHYVFAKSEDQESQQLWEFRLARLRLLQFSERLDTYLGISMGRYPLRQVSSDITKLFAYGFCISEFSDYRKFRSNPINQAAISLAESGRIGALNLLFKRHPYSLVSFMLQILAAIPETVPVETYAHLLPGKSPPTSMAVREEDWVECEKMVKFINNLPENGKNDSLIQTEPIVRRCLGYNWPSSEELAAWYKSRARDIDSTTGLLDNCICLIDIACRKGISELEQFHEDLSYLHQIIYSDEIGGEICFSLSLAGWEHLSDYEKFKIMLEGVKADTVVRRLHEKAIPFMQKRFLGTNNQNVESFLVKWLKEMAAKSDMDLCSKVIDEGCIDLYTVCFFKDDVEAVDCALQCLYLCKVTDKWNVMATMLSKLPKINDKAGEDIQRRLKRAEGHIEAGRLLEFYQVPKPINYFLEVHLDEKGVKQILRLMLSKFVRRQPGRSDNDWACMWRDLRQLQEKAFYFLDLEFVLTEFCRGLLKAGKFSLARNYLKGTGSVALPSEKAESLVINAAKEYFFSAPSLASEEIWKARECLNIFSSSRTVKAEDDIIDAVTVRLPKLGVSLLPVQFKQVKDPMEIIKMAITGDPEAYLHGEELIEVAKLLGLNSSEDISSVKEAIAREAAIAGDMQLAFDLCLVLTKEGHGPIWDLGAAIARSPALEHMDISSRKQLLGFALGHCDDESISELLHAWKDFDLQGQCETLGMLSESNSPEFQKMDGVSCLTDFPQMLDGLSSDQQLDLDRAKDSISCVAKDMPVDDSVDLESLLKENGKLFSFAASHLPWLLKLGRNRKLDKSLVLDSIPGKQFVSIKATALITILSWLAKNGFAPKDELIAMITDSIIEHPVTKEEDVIGCSFLLNLVDASNAVEVIEKQLRIRGNYQEIRSIMSLGMIYSLLHDSGVECTAPIQRRELLQKNFERKQTESLADDMSKIDKLQSTFWKEWKHKLEEKMHDADRSRMLERIIPGVETERFLSHDIEYIKVAVFSLIESVKSEKKLILKDVLKLADTYGLKQSEVILRYLSSILCSEIWTNEDITAEILQVKEEILTFASDTIETISTIVYPAASGLNKQRLAYIYSLLSECYCHLAESKEASLLVQPNSSFAGLSNWYNVLKQECSRVSFIKDLDFKNISELGGLNFDSFNNEVHAHINEMNLEALAKMVETLSGLSMENSSKGLISCQDVYKQYIMNLLDTLESRRDLDFGSAESFQGFLGQLEKTYDHCRVYVRILEPLQAVEILKRHFTLVLPPNGSYMHIPDSSTWQECLILLINFWIRLADEMQEVKSSNPSLVENLTLSPECISSCFTLLIKLVMYDSLSPSQAWAAILVYLRSGLVGDCATEIFNFCRAMVFSGCGFGPISDVFSDMSSRYPTALQDLPHLYLSVLEPILQDLVSGAPETQNLYRLLSSLSNLEGNLEELKRVRLVVWKQLVIFSENLELPSQVRVYSLELMQFISGKNIKGSSSELQSNVMPWDGSAELLSSMQKTEAALNQALPDQADGSSRLTNTLVALKSSQVAVAAISPGLEISPEDLSTVETSVSCFSKLSAAVTTASQAEALLAILEGWEELFEAKNAELLPSNEATDQGNDWGDDDWNDGWETLQESEPVEKVKKECVVSAHPLHSCWLDIFRKYIALSMPENVLQLIDGSLQKPEEVIIEETEAESLTGILARTDPFLALKISLLLPYKQIRSQCLSVVEEQLKQEGIPELSSQSHHEVLLLVIYSGTLSTIISNACYGSVFSFLCYLIGKLSREFQEERITQADNRESNASSESRFISCFGQLMFPCFVSGLVKADQQILAGFLVTKFMHSNPSLSLINVAEASLRRYLDKQLESLEHLEDSFAESSDFETLKNTVSSLRGTSKEVIRSALASLSNCTNSR
Protein: UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 1 (EC 2.4.2.-) (Rhamnogalacturonan xylosyltransferase 1) (Q9ZSJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of D-xylose from UDP-alpha-D-xylose onto L-fucose. Probably involved in the biosynthesis of rhamnogalacturonan II (RG-II) through xylosylation of the internal fucose moiety of the A-chain of RG-II, a structurally complex pectic polysaccharide of the primary cell wall. RG-II is essential for the cell wall integrity of rapidly growing tissues such as roots and pollen tube growth and elongation.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:17056709}; Single-pass type II membrane protein {ECO:0000305|PubMed:17056709}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- AUGMIN subunit 6
- Xylogalacturonan beta-1,3-xylosyltransferase
- Probable pectin methylesterase CGR3
- Probable arabinosyltransferase ARAD1
- Glycosyltransferase
- Xyloglucan 6-xylosyltransferase 1
- GDP-mannose 4,6 dehydratase 2
- Uncharacterized protein At4g19900
- Glycosyltransferase-pyrophosphoryl-undecaprenol N-acetylglucosamine transferase)
Sequence:
MEQKQHILKQSTFSSSPSSYSSISDRPISLLSRNGLLLLLLALVLLLGVLLPWPGSPLFLFPNRLSSSLSPSPQSKWRDYTLAQAARFVAKNGTVIVCAVSSPFLPFLNNWLISVSRQKHQDKVLVIAEDYITLYKVNEKWPGHAVLIPPALDSKTAFSFGSQGFFNFTARRPQHLLQILELGYNVMYNDVDMVWLQDPFLYLEGSHDAYFTDDMPQIKPLNHSHDLPHPDRNGETYICSCMIYLRPTNGAKLLMKKWSEELQSQAWSESIRFKANDQPAFNLALNKTAHQVDLYLLSQVAFPTGGLYFKNEAWVQETKGKHVIVHNNYIIGYDRKMKRFQDYGLWLVDDHALESPLGKLE
Protein: Cyclin-O (P22674)
Organism: Homo sapiens (Human)
Function: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24747639}. Nucleus, nucleolus {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}. Note=Localizes to the apical part of cytoplasm. {ECO:0000269|PubMed:24747639}.
Interaction partners:
- Cyclin-dependent kinase 2
- Multicilin
- Cell division cycle protein 20 homolog B
- Radial spoke head protein 4 homolog A
- Cyclin-dependent kinase 3
- Coiled-coil domain-containing protein 39
- Cyclin-A2
- Coiled-coil domain-containing protein 40
- Cyclin-dependent kinase 1
- Cyclin-dependent kinases regulatory subunit 1
Sequence:
MVTPCPTSPSSPAARAGRRDNDQNLRAPVKKSRRPRLRRKQPLHPLNPCPLPGDSGICDLFESPSSGSDGAESPSAARGGSPLPGPAQPVAQLDLQTFRDYGQSCYAFRKAQESHFHPREALARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFLTTTPVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFTLGAPTISFFLEHFTHARVEAGQAEASEALEAQALARGVAELSLADYAFTSYSPSLLAICCLALADRMLRVSRPVDLRLGDHPEAALEDCMGKLQLLVAINSTSLTHMLPVQICEKCSLPPSSK
Protein: Protein shisa-6 (Q6ZSJ9)
Organism: Homo sapiens (Human)
Function: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3UH99}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UH99}.
Interaction partners:
- Disks large homolog 4
- Protein cornichon homolog 2
- Voltage-dependent calcium channel gamma-8 subunit
- Voltage-dependent calcium channel gamma-3 subunit
- Voltage-dependent calcium channel gamma-2 subunit
Sequence:
MALRRLLLLLLLSLESLDLLPSVHGARGRAANRTLSAGGAAVGGRRAGGALARGGRELNGTARAPGIPEAGSRRGQPAAAVAAAASAAVTYETCWGYYDVSGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDTSPKENTPVRSSSKNHYTPVRTAKQTPEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV
Protein: NdvB (Q9I4H4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- TonB-dependent receptor
- Probable outer membrane protein
- Probable secretion protein
- PelC
- Uncharacterized protein
- Probable major facilitator superfamily
- Probable ATP-binding/permease fusion ABC transporter
Sequence:
MSSRKIGLNLVVIVALAALFTGIWALYNRPVSVPDWPERISGFSFSPFRLNQNPQSGRYPSAEQMRTDLELVARHTHSIRTYSVQGALGDIPALAEAFGLRVSLGIWLGPDLASNEAEIARAIRIANESPSVVRVIVGNEALFRREVTAEQLIAYLDRVRAAVKVPVTTAEQWHVYREHPELAQHVDLIAAHVLPYWEATPVADAVDFVLERARELKAAFPRKPLLLAEVGWPSNGRMRGSAEATPADQAIYLRRLTNALNGEGYSYFVIEAFDQPWKVSAEGSVGAYWGVYNADRKAKFNFTGPVVPIPKWRALAIASAVLAVLAFTLLLIDSSSLRQRGRTFLAVVSFACASVLVWIAYDYSQQYSTWFSLTVGALLGVGALGVVIVLFTEAHELAEAVWTRKRRRPFLPITAARAYRPKVSIHVPCYNEPPELLKQTLDALARLDYPDYEVLVIDNNTRDPAVWQPVEAHCARLGERFRFFHVAPLEGFKAGALNFALGHVAADVEVVAVIDADYCVDPDWLRHMVPHFGDPRIAVVQSPQDYRDQHESAFKRLCYAEYKGFFHIGMVTRNDRDAIIEHGTMTMIRRSVLDELRWPEWCITEDAELGLRVFEKGLSAAYFERSYGKGVMPDTFIDFKKQRFRWAYGAIQIMKRHTDALLRGRGPDGSRLTRGQRYHFVAGWLPWIADGLNIFFTLGALLWSAAMIIVPKRVDPPLLIFAILPLALFVFKVGKILFLYRRTVGVDLRDSFFAALAGLSLSHTIAKAVLYGFVTRGIPFFRTPKMRSSHGLLVALAEAREEVFVMLLLWGAAAGIVAVQGVPSRDLLIWVAMLLVQSLPYLAALVMALLSSLPKPREELAGGAEQIGG
Protein: Groucho-related gene 4 (Q8JIM6)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRTAEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGFDKTRLLKKDAPISPASIASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASGLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPGIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) (Q969G3)
Organism: Homo sapiens (Human)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:12192000}.
Interaction partners:
- SWI/SNF complex subunit SMARCC2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- AT-rich interactive domain-containing protein 2
- Bromodomain-containing protein 7
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- PHD finger protein 10
- Protein polybromo-1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- Actin-like protein 6A
- AT-rich interactive domain-containing protein 1A
Sequence:
MSKRPSYAPPPTPAPATQMPSTPGFVGYNPYSHLAYNNYRLGGNPGTNSRVTASSGITIPKPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQEYLNEYEAEKIEYNESMKAYHNSPAYLAYINAKSRAEAALEEESRQRQSRMEKGEPYMSIQPAEDPDDYDDGFSMKHTATARFQRNHRLISEILSESVVPDVRSVVTTARMQVLKRQVQSLMVHQRKLEAELLQIEERHQEKKRKFLESTDSFNNELKRLCGLKVEVDMEKIAAEIAQAEEQARKRQEEREKEAAEQAERSQSSIVPEEEQAANKGEEKKDDENIPMETEETHLEETTESQQNGEEGTSTPEDKESGQEGVDSMAEEGTSDSNTGSESNSATVEEPPTDPIPEDEKKE
Protein: General transcription factor IIH subunit 1 (D3ZYG3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATESSTSSHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTALEDKPLDEGYGISSVPSTSNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSVDGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAVNQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKLVTHIEEMLQTAYNKLHSWQSRRLMKKT
Protein: Photosystem II reaction center protein M (PSII-M) (P0C412)
Organism: Oryza sativa subsp. indica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00438}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00438}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II reaction center protein I
- Photosystem II reaction center protein H
- Photosystem II protein D1
- Photosystem II CP43 reaction center protein
- Photosystem II D2 protein
- Photosystem II reaction center protein L
- Photosystem II reaction center protein Z
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein J
Sequence:
MEVNILAFIATALFILVPTAFLLIIYVKTVSQND
Protein: Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein (Q5A352)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- Phosphatidylinositol-3,5-bisphosphate 5-phosphatase
- 1-phosphatidylinositol-3-phosphate 5-kinase
- Presequence translocated-associated motor subunit PAM17
- DNA-dependent ATPase
- Vac7p
- DNA repair and recombination protein RDH54
- Autophagy-related protein 18
Sequence:
MTTGKVLEPSLVKDLSNHIYEKRKATAFQIESLTKNALGHNDSQTIYKIINELTELTSTGTNSAKMGAITALGSVSVALGSFAIAYFLEDIVKPIFSTFKDTDARVRYYACESLYNVAKIARGEILIYFNDIFDILCILVSDSESSVKNAADILDRLVKDIVSAKATNYVSILQQQQESQIRSNLVDAQGNAIQVNEPQDPSKAFSLPKFVPTLLERMYTTDPFTKKFLLSWLELFDDIPSLELVRFLPEFLKPLIQFLFNNSPTDIRSETENLLNVFLEEIKYITKIKIDARKKELANKKTKQAELDANVKKDKQEHGSPNLKLHDTESAIDEDSGADDEASIKSDDTTIVRRPLASGLTTKPTEGHNKIEVSGSDAKEEHEENEEVTLGQDIFIDYEKIILILLSFLKSPESESSFKDLGSEPHEIYCQVQFIAIKWLRDILEMAPSSILKQFPECVGVTLKNISKTDKAQDFELRDSFLDFNMAMQSFLYKFNDASLDEFNETLGLDKETNTEFNEVKLPLTLSAIVKEYLDSVSELARTTSLDWMIFIYERNPTEFMSLFQAEANNFELTDLLKYDTSNEVILKVLTLMAKISEANQQFFKNFIVKLVKIFELDGTEKTFKVEFIIRKLCVSLNSELIFTALSEVLITLSDLDFLNTMIVTLNNILLTSQELLPFRKKLKGLDSNKVEDWQLFSSLFQSWCHNAPSAISLCLLTSNYELSYLIIKNLSELEVTSQLLIQLDVLVQLLESPIFMKLRLNLLEPEKHPYLFKTLYGLLMILPQSNTFMSLRNRLTTVSNYNSNSGPQFHLSTPLTTPTPAPGTTTAPIPSGSSTTSQSIRRKRIYEMLDKFIKIQDSHEKYNNSNKRMNNPVGYNLESASVFPVNSLK
Protein: Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) (P00488)
Organism: Homo sapiens (Human)
Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Subcellular location: Cytoplasm. Secreted {ECO:0000269|PubMed:4405643}. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Interaction partners:
- Coagulation factor XIII B chain
- Prothrombin
- Fibrinogen alpha chain
- Fibrinogen beta chain
- Fibrinogen gamma chain
- Apelin receptor
- Fibronectin
- von Willebrand factor
- Coagulation factor XII
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM