wanglab/gogpt-training-data huggingface dataset:
Protein: Lipopolysaccharide heptosyltransferase 1 (EC 2.4.99.23) (ADP-heptose:lipopolysaccharide heptosyltransferase I) (ADP-heptose:LPS heptosyltransferase I) (Heptosyltransferase I) (P24173)
Organism: Escherichia coli (strain K12)
Function: Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:9446588}; Peripheral membrane protein {ECO:0000269|PubMed:9446588}; Cytoplasmic side {ECO:0000305|PubMed:9446588}.
Interaction partners:
- Lipopolysaccharide heptosyltransferase 2
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Bifunctional protein HldE
- Lipopolysaccharide heptosyltransferase 3
- O-antigen ligase
- Lipopolysaccharide glucosyltransferase WaaG
- Lipopolysaccharide core heptose
- D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
- Phosphoheptose isomerase
- 3-deoxy-D-manno-octulosonic acid transferase
Sequence:
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWRKAWFSAPIKAERKAFREALQAENYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRAPRENLINLNSQAVLEKLSSL
Protein: Transforming protein Ski (P17863)
Organism: Avian erythroblastosis virus (strain Sloan-Kettering)
Interaction partners:
Sequence:
FHLSSMSSLGGPAAFSARWAQEMYKKDNGKDPAEPVLHLPPIQPPPVMPGPFFMPSDRSTERCETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGTYPPHCKKEFSSTIELELTEKSFKVYHECFGKCKGLLVPELYSNPSAACIQCLDCRLMYPPHKFVVHSHKSLENRTCHWGFDSANWRSYILLSQDYTGKEEKARLGQLLDEMKEKFDYNNKYKRKAPRNRESPRVQLRRNKMFKTMLWDPAGGSAVLQRQPDGNEVPSDPPASKKTKIDDSASQSPASTEKEKQSSRLRSLSSSSNKSIGCVHPRQRLSAFRPWSPAVSANEKELSTHLPALIRDSSFYSYKSFENAVAPNVALAPPAQQKVVSNPPCATVV
Protein: Uncharacterized protein, isoform G (R9PY70)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVTICSLSAALSCNIAYRFPIYEMEHLDLAGYLGHTPQSWNTLGTFQDQDAVYLSSSRQMLEPILEETSEDEERARSSLIVSLDRRSTLWSSTESETGSVLRIETIKDIDAVSERDFVCPPKRPRRSHDLNSGQISEDCVQLRRPMPYDPEYHNSFERFLALEACARDSFGSQGQRSSIGSRRGGTFEDFYSDRDSSHSLSRSSSLVQFESLERQLTLQEQHQSMNSLGNSSPSLTCESGASTRARTRDSSPESRKGSAPTLSLLKRYESSDCSHLHQTYYELNNLNFEYKQQQELLSRSLREAELKSDLESSSSSSSSSDSSGHSLLSSCLVPGDAVATERGKQDGTNSRRIPPNSAENLSEDSGYCEPRTLKREKSKSIPKNFEKLCEEEEELLLLEEGAPHSRDFKDEHDLCQTEIEQTADTAALACSPSSINSSPERASSESESASPLPSPTGSASTSSAASFTWLHNSLPDIREPRGPLSVEINNSKPKTNGSVLATTRQNSGSTRSSSSADSCDGISLLGPTHSLNELQVLERRRRPRHIRPSQRNCHSNSSSEELEELDNLFVACHTPPRIRRSCSWNERARKVVGVASAGYLNASYQNLTLLNYTDNWLPAEILQKNHKRSPAEEMSKQSSNTCGNYEHMICKGNFLLDEISKVYDKNVSILTDKPVLDTKLPAPVECDLNEPIECSKVQHVQLNIKPPPRQKRLTQQPPAAMTFNGLVKTFDQDPTNLRTSYTQSLEQCHLDEQETAKPASYPPSAISQRFLPKRRFQSQTSAAKQRSLVSSTPNLAASDDGQPESEYDIYVSSAHASMHQLPQTTTLPKPLGILLPAGSRHSFGKEVSFCPVVSKYCWQEQSSEEPTEDQFHSSEGEQGPPSDDELMDPTLVHNTRENENIAALFEPEPEQAHRLREPAIAQKFTGFHTNALLSASTHAEKNLSCEESANVKNKANLATPDCRDQRTEAKTTLEPEPALSSTVSLKPCAVANSSCREETPSDAINEPASATARPLSLPILSEPPTNRAHRILYSSQQLRRYEPKASPINKMPPANELSPQAAAVARTDEKHPTSRSLFSRFTHGLRFSLRRKKKQQQQEPSQVKESPKELRQSPEESQPVDFVHIPLKPPRSSQCGRLDDTIVSETSSGHVHSWQQQEQLGKTSTLQKVTGKPPLPKMPPRSGILTHAPQETTGETVNCHRTEALPSVEREHCNQLTGQLVAKVQAQRMRDTGLSSQIVVAEETHTVNRLAGHGDATRPTVVTAVPVSVAPVAEVDKMGLIETNLDTHETVISGKTRSLMDITCNPLSMPHKRYIVKRLNVNSVAYDVDELDAEVKPSPGGMASVRRPHKSMEFLLDKENQKNILPPENELQKSHDHNPGALSEHQLRVQASLQRLNIPDWFRHYNKGPEKAADGENACTSATGGGYRPGNFTRKRAQESGRWQGLNSKTTSLSSLGSQRSDRSPLLMSPSAHSHHGGQSSYSCGSTTIHGPAPVQIGMGATRWSTSHLNSTQMSPGASQRGSFTRGAPINSSFISVASGSGLLRNSYRQPYLGWRSTEKLSQRTPHERLANSLLTQRTAPPSTRAGNETRTLHSVSTEIQSSIKEVTSAIVHFVNDQQQSQHPRSRSTSPNSRCWLESSFVGTRTLDSPQTPVIDNSPPELARKQQQLHPHQVHLDVGLSPVVSAGQLPHRMNGINRIGNGGACAASRQQLEVQSAAELQRLRRRSEGDAPTQEKHYSKEQSHKSNSHSVEAVDSAQPNNPKESRRASLGDPALAATRSDIGSGQLQLIEGPTTGFGSGQHVRCRNTKCDQSTSPSDAKKLYKSCHNCSHLYCSRECRRAHWEKHRKACLHSRASNICRQVLATCKDDIDSQRHLSLLARKGSLSQGRGVVRVLFRSAEAAEGFIKNGFQCMGEASYVRWPDLMPAEMGLELYSELLKLSTEYKPETKMLIYVAICVVSEAPGMGQAPVRWERQLVSRCAKLKLCKTVLAELEQHQAALLQPVSVVAVPERTEILILTFNPGQHSNRELILSNILDILSRRGVMLSKHYPEVFERLQTYSEGQSDKFNPVTLHPRDTQTGQNFVCIIMAVHTDNELTKLPSAADGGNRVTTIDVGSTSALVQLELGDDQICKTKSRES
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (X1WEA3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Autophagy-related protein 13
- Autophagy-related protein 101
- RB1-inducible coiled-coil protein 1
- Beclin-1
- Beclin 1-associated autophagy-related key regulator
- Serine/threonine-protein kinase TOR
- Autophagy-related protein 2 homolog A
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Regulatory-associated protein of mTOR
Sequence:
METVGDFEYSRKDLIGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQETPSSVFLVMEYCNGGDLADYLQAKGTLREDTLRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYTGRKKSSINGIRIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNKSLVPNIPRETSPQLEDLLLGLLQRNQKDRIDFDTFFSHPFLEPISTIKKSCPVPVPSCSGLVSDSTCGSSPSCRYVSPPSLPDMQTLPEDVLSSPPLGPPNYLQLSKESGGSTSSKNSSCDTDDFVLVPHLSGEQSYDLPMGAVGRRPSSEFLLCGGSPQPSTGQTPMVSPRSETTPIPVPTQVRNYQRIKQNLSSSPTTTLYGSPRSGTVRRSNTSPMGFPKMVSASPSPADTVQTVGRRLSTGSSRPYSPSPLVGTIPEQLGHCCCGHPQSHEPRSRSSSGGSPVPSSQLLGARLQSAPTLTDIYQSKQKLHKQLSDPVHPTSSAYPSNHSPQLGRPANLGTSPTKHLGSSPRTSDWLTKSPLPTIIGSPTKVTAPFKIPKTQASCNLMALADSPIPNKTLMDGRELCAHHCTAYPSSRQPAPEASKTSFGRSVSAGRLSEPPVRITLGGQPYQGSTDSLNTERPMDTAPAGMCALAAGGGSPRTVVFTVGSPPSSSTPPTCSHLASRPRATSVGSNSSAGSLCSTSGKVYMGSPPGMTIGSSPPGAEAGPSSLRYVPYGTSPPSLDGFITFEAPELPEETLMEREHTDTLMYLRMMLSFTDCVLEIAALRAGGPDLGASAASLYPPQDSVVVDQISQLSREWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPSTAVKQVVKSLNERYKSCISLCRRLTDKLNHFFSDKQRFVDEINSVTAEKLIYNHAVEMVQSAALDEMFQQTEDIAYRYNKASMLLEGLTKILQDPADIENVIKYKASVDRRISALCYCTVTLYE
Protein: Mu-theraphotoxin-An1a (Mu-TRTX-An1a) (B3A0P0)
Organism: Acanthoscurria natalensis (Tarantula spider)
Function: Is toxic to insects. Reduces amplitude and frequency of spontaneous firing and inhibits voltage-gated sodium current (Nav) in the dorsal unpaired median (DUM) neurons of P.americana.
Subcellular location: Secreted {ECO:0000269|PubMed:23651762}.
Interaction partners:
Sequence:
IIECFFSCEIEKDGKSKEGKPCKPKGDKDKDKKCGGWRCKIKMCIKI
Protein: Cntp (A0A1D8PHJ7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Purine-cytosine permease
- Amino acid permease/ SLC12A domain-containing protein
Sequence:
MVSPSTDKAPSIVELTPETYQQDVSSDSIDLESGTKKLQNESALQSHEYTTNIDETSSSNTASKLTYIQKLKIRFPYYRLAIDIFIGCFFTAWWLSIVIQPKHRHQWLIPTVIWGMIMVRLITWHIKILPWLLNKVKIVWDFFTGYVYKVLSKKYQRLITGAVITVGVILLGTFVPSETEYSKRKDRAISFFGCIVAIFLLFVTSKAPSKINWNAVIGGMLMQFIIALFVLRTKCGYDVFNFISTLARELLGFAKDGVAFLTNKDVSQLGMFFFTVLPSVAFFVAFIHIWYYFGVIQWAIRKFAYFFFWTLRVSGAEAITAAASPFIGIGESAILIKDLMPYLTKAELHQIMTSGFSTISGAVLVGYIGLGLNPQALVSSCVMSIPASLAVSKLRYPELENPISSGTVMIPKVEDPEEAREKSKDEPQNVLQAFSNGATLGLRIAGTMMIQCMCIIGLVALCNGILTWFGNYWNIDHLTLELMLSYIFYPIGFLLGTPRNEILLVSKLIAYKFIQNEYVAYNLLTNEAPYNEMSKRGTLIATYACCGFANLGSLGITLGVLNTLTNNSRAKDISSSIISALFCGAIATMLSAAIAGMVMHDLNTFHIN
Protein: Nucleusenvelope protein (Uncharacterized protein At2g43630) (Q8VYY8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable plastid-lipid-associated protein 12, chloroplastic
- At4g13500
- Protein TIC 20-I, chloroplastic
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic
- Protein TIC 56, chloroplastic
- Protein TIC 55, chloroplastic
Sequence:
MSFTQANCFRPSYYPARITRPNCISSVPIRSSVRFDHFPRTSFTLRATAAVSTQFSPLLDHRRRLPTGKSKQSSAVCLFGGKDKPDGSDEISPWKAIEKAMGKKSVEDMLREQIQKKDFYDTDSGGNMPPRGGGSGGGGGNGEERPEGSGGEDGGLAGIADETLQVVLATLGFIFLYTYIITGEELVKLARDYIRFLMGRPKTVRLTRAMDSWNGFLEKMSRQRVYDEYWLEKAIINTPTWYDSPEKYRRVIKAYVDSNSDEAYVESNSDEVSY
Protein: Poly(A) RNA polymerase gld-2 homolog B (EC 2.7.7.19) (Protein wispy) (Q9VYS4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and the centrosomes of the mitotic spindle. Required at the final stage of oogenesis for meiosis I metaphase arrest and for progression beyond this stage.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10747060, ECO:0000269|PubMed:18430932}.
Interaction partners:
- Maternal effect protein oskar
- FI20148p1
- Homeotic protein bicoid
- Protein matrimony
- CG5272 protein
- Protein swallow
- Deubiquitinase otu
- Vitellogenin receptor Yl
- Chorion peroxidase
- LD24340p
Sequence:
MFSTRISGDMKIFAADVAESSVTATCNTSVQQQQSQQLEFRTRMSAGSPSSKSGQCHLKFGKYNNKTANLLRQVNSCHSSNSSSNTSNNNNEAIKGQQQQPLHYCNSNNSHSWARKKYFGNGNSNNSLLQQQQQPSSFFQRQQQQHQMQMQQEKQATNNNDALMKNQNVVNAHVSDCKSSDSNNNSTSSSNNNSTISSNNNNTSSASNNNTGSSSSCSNRTKPAKWLNENSSSSSSSNNNNISCRNNNTSSIDTKRRNSSAGATAAYYRKSESESGSSEGAAESTETEATRTGGCNSNRTAESSSADGGTQATMGKSQDQEQDQTVKQRPRQQPLSFWKTNYPQTSATQLKDKETVAAVVSAAAVAAAAAAASASEQQQQQQSLSIEHRRNSGYQQHQQHNYYPYYYSQPKQLTIASFLQKEMLPDSTEKSSSNTGGSNMIRSSSNGNSNFSRHQYGHQSTGSGYQQQQQRYRNAQNVYQQYQHQQQHHAQQHTHPHFRRKHSDNGSGINKKMHYSPPGKSGDPADRSASGQQQHHHPHQQQKTIEILASSHFNAMHRRMQGGNNKNGYYQHSYNPMTGEVGSTPTRSEHQNIYNLTYIHVDTEATGEAASAAGSTPVVKPSLLSKPNISITPASSTTPTTVDRALLPAVRSVSAPASGSALPAPANHVRNMFPPPPLAMLGGHGLLSPVTTTTPTKMISCAQLDEAITAAAASGDKLSTSPSYNQAGHYIMPPQQQQQQQLSSHPIPTGTSSHPPPPPPPHMFFHFADGFCNPGQGHQAPPATMWPHSSSPCYPASYGSSCGSGTGAGTSPHNNDGNAGALRPASPALSSSSLGSESQWSGTSNRSRLGHNGHPSISPTPSALGSAQLSPHLAEMRVQHPLHQQHPPSHASHRPHGQMGGHAMSSYVPHRPPPPPHPSISSPNPTPVATGAGGPWYEMILPPDRYLAQARNIEVTVQPEKLICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMFERYRICLVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQDFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDINDAKRMTISSYSLVLMVLHYLQHACVPHVLPCLHSLYPEKFQLGQQDCLDLDLIEPIEPYQALNTQTLGEHLLGFFKYYSTFDFRNFAISIRTGGVLPVSTCRMAKSPKNDVYQWKELNIEEPFDLSNTARSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPIHHVPEHFPQLQQHQQQFEQQLHHPISGQQRSAGGGGDGANPVPSTLNPDAASTFAETTAAHVA
Protein: Probable 3',5'-cyclic phosphodiesterase pde-6 (EC 3.1.4.17) (Q9N2V9)
Organism: Caenorhabditis elegans
Interaction partners:
- Probable 3',5'-cyclic-AMP phosphodiesterase pde-4
- adenylate cyclase
- AMP deaminase
- Putative cytosolic 5'-nucleotidase 3
- Adenylosuccinate lyase
- Adenosine kinase
- Adenylate kinase
- Adenine phosphoribosyltransferase
- Adenylate kinase isoenzyme 1
- Adenylate kinase isoenzyme 6 homolog
Sequence:
MGDRSGVGGEEGEKSVLGASAHSQAGRRQQHTPAARRGAQRAPAATAAAASRPVFAMRWCCGGSYSENGGGGGGSRGAPPTPLLTVAATSSSTAHDTFGPMQVKMLKTAVIVTEGTGESVLLDSLRASGWICTVSFPTQATSDVESICPLAVFIDLRVPHPSQIAKDVSSVSTEEVLIVSIAEKHISEKRRRALAQSNIIHHVTWNTRDVVLFDYVGRLANRIRALPALFAVLDETDQAVEICDEQRVVQYVNRAYENVTGCIRSEVIGQPESEMRRKSLPRARGEEERRRSCDWKFIRVPFANNSQFVYMKRSNTTGDTAAIFRDVSLKSLKSQTGGIEAPISEVLTMLRDVSARVDGEPAQTIKDAMKVLSSHELYAPSINRFRDADRIATQYYDGLIRLHHPARQRKRSVVDAHREKRGSHGERRRVSADVKNALENDNCWKFDILHLEKVSDHHALSQVGMKVFERWKVCDVLGCSDDLLHRWILSIEAHYHAGNTYHNATHAADVLQATSFFLDSPSVAVHVNESHAVAALLAAAVHDLDHPGRGNAYLINTRQSLAILYNDNSILENHHIALAFQLTLQHNANVNIFSSLSREEFIQMRHAMVEMVLATDISRHFEYLAKFNKMHVTDVPEEQRDTNSLTICDMLVKCADISNPAREWGLCQRWAHRIVEEYFEQTREEKEKGLPVTMEVFDRNTCNVPITQCGFIDMFAREAFATFTEFAKLGELSDQLESNYEKWKVMTSQWTPTHNTNLVL
Protein: Zinc finger E-box-binding homeobox 1 (Transcription factor 8) (TCF-8) (Zinc finger homeodomain enhancer-binding protein) (Zfhep) (Q62947)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q64318}.
Interaction partners:
- C-terminal-binding protein 1
- Mothers against decapentaplegic homolog 3
- Zinc finger E-box-binding homeobox 2
- C-terminal-binding protein 2
- Cadherin-1
- Catenin beta-1
- Cadherin-2
- Twist-related protein 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Histone deacetylase 1
Sequence:
MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEEESVTDAADCEGGVPDDELPTDQTVLPGGSDRAGSAKNCWQDDVKDDECDSDAENEQNHDPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASGHDDNGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLMPVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSGGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNIIRQVLENNQASLASKEQEAVSASSIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPGQLQVVPQNLKKENPAPPKSCKSEKSPEDLTVKSEKDKSFDGAADESTCLLCEDCPGDLNALPELKHYDPEHPAQPPPPAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPSTEELTKIADSVNLPLDVVKKWFEKMQAGQIPGQSLEPPSPGPGSGNIPAKTEEQPQPVDGNEPQEDSTRGQSPLKMTSSPVLPVGSAINGSRSCTSSPSPLNLSSARNPQGYSCVSEGTQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSATVSPAMQEPPVKVIQPNGNQDERQDTSSEGVSVEDQNDSDCTPPKKKTRKAENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDAMEQEDTGPEALPEVLPTELVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEELQEDKECENPQEEEEEEEEEEEEEEEEEEEEAEEAEHEAAAAKTGGAVEEEAAQQAGSFQQKASGSESKRLSEEKTNEA
Protein: Protein SDA1 homolog (SDA1 domain-containing protein 1) (Q80UZ2)
Organism: Mus musculus (Mouse)
Function: Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Ribosome biogenesis protein NOP53
- GTP-binding protein 4
- Pescadillo homolog
- Nucleolar GTP-binding protein 2
- Guanine nucleotide-binding protein-like 3
- Notchless protein homolog 1
- Nucleolar protein 14
- WD repeat-containing protein 43
- Guanine nucleotide-binding protein-like 3-like protein
- MKI67 FHA domain-interacting nucleolar phosphoprotein
Sequence:
MSGRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNMEIFKLQPNKPSKELAELVMFMAQIGQCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKITKILVAALTFFLGKDEEEKQDSDSESEDDGPTARDLLVQYATGKKGSKNKKKLEKAMKVLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESCKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLVTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARIQEYGELDAKDYIPGAEVLELEKGENTEDDEDGWESASLSEEEEEDGEWVDVHHSSDEEQQAIATKLDSMPMEERKAKAAAISTSRVLTQDDFQKIRMAQMKKEMDAAPGKAQKRKYLEIDSDEESRGELLSLRDIERLHKKPKSDKETRLATAMAGRTDRKEFVRKKTKINPFSSSTNKEKKKQKNFMMMRYSQNVRSKSARSFRDKQLALRDALLKKRKRMK
Protein: Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) (Q8NET8)
Organism: Homo sapiens (Human)
Function: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Subcellular location: Cell membrane {ECO:0000269|PubMed:26818531, ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}; Multi-pass membrane protein {ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}. Cytoplasm {ECO:0000269|PubMed:26818531}. Lysosome {ECO:0000269|PubMed:26818531}. Note=Targeted to lysosome for degradation in a SNX11-dependent manner. {ECO:0000269|PubMed:26818531}.
Interaction partners:
- Transient receptor potential cation channel subfamily M member 8
- Hypoxia-inducible factor 1-alpha inhibitor
- Ankyrin-1
- Ankyrin-3
- Ankyrin-2
- Transient receptor potential cation channel subfamily M member 3
- Transient receptor potential cation channel subfamily M member 4
- Transient receptor potential cation channel subfamily A member 1
- Short transient receptor potential channel 5
- Transient receptor potential cation channel subfamily M member 7
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
Protein: CD276 antigen (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) (Q8VE98)
Organism: Mus musculus (Mouse)
Function: Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- T-lymphocyte activation antigen CD86
- T-lymphocyte activation antigen CD80
- Cytotoxic T-lymphocyte protein 4
- CD40 ligand
- T-cell-specific surface glycoprotein CD28
- Tumor necrosis factor receptor superfamily member 9
- Tumor necrosis factor receptor superfamily member 4
- Inducible T-cell costimulator
- T-cell surface glycoprotein CD4
- Interleukin-2
Sequence:
MLRGWGGPSVGVCVRTALGVLCLCLTGAVEVQVSEDPVVALVDTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYSNRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGNMVTITCSSYQGYPEAEVFWKDGQGVPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPLTFPPEALWVTVGLSVCLVVLLVALAFVCWRKIKQSCEEENAGAEDQDGDGEGSKTALRPLKPSENKEDDGQEIA
Protein: Uncharacterized protein C630.07c (Q9UUH5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C1734.10c
Sequence:
MDQYRDLPKEDPDTAIEYESGVDEESSLKIEKFRVLIFGKDNSQDDLVKSVFNLSKLSEKEKMPFGIKCESEENPNFESYHSKVGKKSCKRFMRWLKANAFAEERDIDCIWYQLNLLDISDEDILCLQYLQGCLIPIVSIIYDFNEFLSPFTKSFLSKIGESNTITVKGMPLADVLVFRKKVLKLVSQLSFMTDRKELVYTTCLALEDDDAYTNFVSAQQEDSSCKFYGGILIGVSHCKYAAAGASYPLPIPASGLLAQKLAIGLLCKDIIKLWNLCPESSILTKEILLELPKASDVAKSIGKMILTSMFVPLWLLKGIWEAPATAKIIIGSIADVTLPVQRMYYFIKAGGKLDVPTIHAFYQHYKEFVRPKCLEHIAEITTFNVVTAFSSEAVYQEAIRLLDRFRYVSKSSEEDLIVPSFVVNDLITYD
Protein: Fatty acid elongase 4 (EC 2.3.1.-) (Beta-ketoacyl-CoA synthase) (Elongation of fatty acids protein) (PUFA Delta5 elongase) (Q57X51)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMDCRDASACQGVGSLCFFPYLNPLVSWHALVLGHLLYLFVVFVMRSIMRGRRALNMSRVLVVYNVLQICLSAAMAINLSPPLKNGVFNLSGKFCPDIEFWMFVHYCSKYIDMLDTVFILCKKKEDQLSFLHVYHHCTIGLIWGILLRNGLANGTAFFGTWINSSVHFLMYSHYLWTSLGYRNPFKFLLTKIQMLQFSLCILHAILVTLLDTQFTLGWNLLQLLYNASLLVLFLNFYMNSRGKGCAIEKKPQ
Protein: Endolysin LytA (D-alanyl-glycyl endopeptidase) (EC 3.4.22.-) (LytA amidase) (N-acetylmuramoyl-L-alanine amidase) (EC 3.5.1.28) (Q8SDS7)
Organism: Staphylococcus phage phi11 (Bacteriophage phi-11)
Interaction partners:
Sequence:
MQAKLTKNEFIEWLKTSEGKQFNVDLWYGFQCFDYANAGWKVLFGLLLKGLGAKDIPFANNFDGLATVYQNTPDFLAQPGDMVVFGSNYGAGYGHVAWVIEATLDYIIVYEQNWLGGGWTDGIEQPAGVGKKLQDDNMLMISLCGLSVRILKVRQRHDQFNLLHKHPKKETAKPQPKAVELKIIKDVVKGYDLPKRGSNPKGIVIHNDAGSKGATAEAYRNGLVNAPLSRLEAGIAHSYVSGNTVWQALDESQVGWHTANQIGNKYYYGIEVCQSMGADNATFLKNEQATFQECARLLKKWGLPANRNTIRLHNEFTSTSCPHRSSVLHTGFDPVTRGLLPEDKRLQLKDYFIKQIRAYMDGKIPVATVSNESSASSNTVKPVASAWKRNKYGTYYMEESARFTNGNQPITVRKVGPFLSCPVGYQFQPGGYCDYTEVMLQDGHVWVGYTWEGQRYYLPIRTWNGSAPPNQILGDLWGEIS
Protein: SAGA-associated factor 11 homolog (Q9VVR6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.
Subcellular location: Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:22989713}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:22989713}. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Interaction partners:
- Transcriptional adapter 1-2
- SAGA factor-like TAF6
- Ubiquitin carboxyl-terminal hydrolase nonstop
- Enhancer of yellow 2 transcription factor
- Transcriptional adapter 2b
- Protein will decrease acetylation
- SAGA-associated factor 29kDa
- histone acetyltransferase
- Transcriptional adaptor 3, isoform C
- Transcription initiation factor TFIID subunit 12
Sequence:
MSAANMPTTTGAQGSGNQVPTTSTTIVNHFRELIKEPKNLDEAANYLYQSLLDDAVVGIFNETHHLRKSGNLAALDGVPEDSTYRMCEMPNLDIFGISTAKKPMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGATSAHLHSSGNTGGTDDEDDVDWSSDKRRKKSNQNSRNNGSKKNNGKTF