wanglab/gogpt-training-data huggingface dataset:
Protein: Glycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein) (Q9NZC3)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein {ECO:0000255}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250|UniProtKB:Q9JL55}.
Interaction partners:
- Regulator of G-protein signaling 16
- 
- N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
- Regulator of G-protein signaling 2
Sequence:
MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREAVAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESHLGSSYITDSMVEDCEPHF
Protein: RE37250p (Q8MYZ5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MADEEIMQTVQTEVKKTTKKVKKSSKRRESEVQISEVEVDATIEERGGEYTKAMDKDWHSGHFCCWQCDESLTGQRYVIRDDHPYCIKCYENVFANTCEECNKIIGIDSKDLSYKDKHWHEACFLCFKCHLSLVDKQFGAKADKIYCGNCYDAQFASRCDGCGEVFRAGTKKMEYKTRQWHENCFCCCVCKTAIGTKSFIPREQEIYCAGCYEEKFATRCIKCNKVITSGGVTYKNEPWHRECFTCTHCNITLAGQRFTSRDEKPYCAECFGELFAKRCTACVKPITGIGGTRFISFEDRHWHHDCFVCASCKASLVGRGFITDGPDILCPDCAKQKLM
Protein: Probable alpha-1,6-mannosyltransferase MNN11 (EC 2.4.1.-) (Mannan polymerase II complex MNN11 subunit) (M-Pol II subunit MNN11) (P46985)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for synthesis of full-length mannan chains.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:9430634}; Single-pass type II membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:9430634}.
Interaction partners:
- Mannan polymerase complexes subunit MNN9
- Mannan polymerase II complex ANP1 subunit
- Putative glycosyltransferase HOC1
- Probable alpha-1,6-mannosyltransferase MNN10
- Mannan polymerase I complex VAN1 subunit
- Alpha-1,2-mannosyltransferase MNN2
- Initiation-specific alpha-1,6-mannosyltransferase
- Dolichyl-phosphate-mannose--protein mannosyltransferase 4
- Dolichyl-phosphate-mannose--protein mannosyltransferase 2
- Dolichyl-phosphate-mannose--protein mannosyltransferase 3
Sequence:
MAIKPRTKGKTYSSRSVGSQWFNRLGFKQNKYGTCKFLSIITAFVFILYFFSNRFYPISRSAGASYSPSHGLYINEIPASSRLIYPHVEHVPVLKQMTVRGLYITRLEVDGSKRLILKPEENALTDEEKKKTTDQILLVKHSFLDHGKLVYRKSNDAPEVVVVTLIDFENYELETIIQIVQNRVDYAQKHQYGVYIRWIQEFLPVLENQNLAESYEFIKPLVIRAAMHAFPTAKYIHFVDQDALLMNLDLSLQKYLLDPKIMDLALLKNVPVVANSNIKTYNHFEYSSAKIIIPHDADGNIDASSFVIANDFYGKALIDYLNDPLLRNFPWDNTGDKLSAAIGHILQWHPTLLGKTAIVIPKVLASQYDASLDQEGESGNGASNGDVYHYNEGDLAASFKGCRSRGTCASEIGHMYQKIKKS
Protein: Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 7/17 (Q7N5I6)
Organism: Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) (Photorhabdus luminescens subsp. laumondii)
Interaction partners:
- Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 7/17
Sequence:
MDNNMLLNQSLEENKLPNSEVPAATLNILTGQVQGAARSAGIFTKEDLINIKLYVKNGLELPFTLPTVKEYIHYNDTNIEGLKPENIKTLFEEIHNHALSWSKVEDKVQQQSIDLENAGKQITQKGESIIKIIEKMPITDSIETLKNTYNNRKPTNEQLFKITYTDVDKKVAVGLKSILESMEKDVKGYRENSQQVKDAITDFKITLFGGTLSDGKTADGLLPQVDTKKKLMDDNNLSTTVKELQDEINEKKRDIEQLQKDYDQYVKLSLSGAISVIGVVITGSIFGPKAENARKQKNELIEKVKELQEQIKGASALQTALQNLSLHFLNIRSCMQDAEVALKHLDVMWSTMLEQINLSKKSFAEIDNASMLLMFEETFKQAISPWKEVQGSAEKLVKIFDEALAEYKKRSK
Protein: Leucine-rich repeat protein (LRRP) (Q57VR9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTENSLSTTITTDVIKRICVKTGFYRNPVCNEKLYLHNKGFDSIEEGAFDPYTDVKVLWLEGNAFTVIHCGKDSQPCNVQAEGQGAGTEEEVNAYTEASATDTTQVMSKSAHLDCCADWLERSQVDSSGAAGCVRSAEYGINSKTDGAAALAFKSTATKSSCNAGRATKDVFQSLYPTLRQLYLHNNALRRMPDLSSFQFLDSVNLSSNCIRSVEVSCAPFDKKAAQYEEELTTKANAIVANSKSMQRELNSSPTGGKLLQQQSDEITEDATGSPEVTQEEGIHINEKVSGDGCDVGNAVNDPGRDGNLEAWCKRLDAYASFCPHKPLDPLEDGKPLSEVPDEYRTPCSSLRTLNLACNYLTAANDIIQLLCYKNLSVLDLSNNQLADGEAVLLVLERMYRLRALKLSGNPLVRTIPRYRKTVLARCSKLFHLDDRPVFDGERRLVTAWARGGDEAEKKELLLMKQEERDQHMRRLREFRETLGLAAHGGLGASETVRLSASGAHVERYNDQGRDNRIFIDNDNVGNINDDAELTSSETGEEDSNEAVANGTNNNRRASGNDAPRAFTSNTSHEGISDPEMWRDVSVTNFTGSDDEDDDGDIFIPPRN
Protein: Cruzioseptin-2 (CZS-2) (A0A193H362)
Organism: Cruziohyla calcarifer (Splendid leaf frog) (Agalychnis calcarifer)
Function: Has antimicrobial activity against Gram-negative bacterium E.coli (MIC=26.35 uM), aginst Gram-positive bacterium S.aureus (MIC=6.59 uM) and against fungus C.albicans (MIC=13.18 uM). At higher concentrations also has a bactericidal and fungicidal effect. Has hemagglutinating activity against horse erythrocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:27321580}.
Interaction partners:
Sequence:
MAFLKKSLFLVLFLGLVSLSICEEEKREEENEEVQEDDDQSEEKRGFLDVIKHVGKAALGVVTHLINQGEQ
Protein: Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (LdlCp-related protein) (Q9VF78)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for normal Golgi morphology and function.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 5
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 52 homolog
- Syntaxin-5
Sequence:
MHDPVKKSAHLTAGSTSTAEKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSANLVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINKLQDLIDRKLSGEQPIKAVDLERAALDLIQLKFHEKHCFKHLSPDHQGKIQQLEEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQLQNSPQGLAGIYSKILNFISLHMTDLLRLTLYSDKFPGFNFVVNSYWSDVETRLELHMNSIFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEIAGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLRLSRWITDAITQSKGSNFSKPYTRNQLLIALHADIRKLDAHLPELQQLIIKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTLVELLIGECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASHITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDVTSWRQELCKLNFQATQIDKLVELTNMVEDSIKLKDNSA
Protein: Tetrapeptide repeat homeobox protein 2 (P0DV77)
Organism: Homo sapiens (Human)
Function: Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3. Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MQDPGHLQGPPLALDPPRRQRQERTVYTESQQKVLEFYFQKDQYPNYDQRLNLAEMLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLVPVAAASFPGGPEFPQGRGSWISPQPGPWGVLPAAEPKIYSLPRTWGGPECGTQEGLKAVPAPGPGPIPAPIPGPAQIPGPVPGPAPNLGPMSGPLSVSIPGPIPAPISCPGPIPDPVLGRTLMPGPGSLPTPAPGALWPQSPYASNLSPDTQLYPDFTKLLPLLDRFEESSLSTTTSQYKEEDGFVDKNHSVPRSLLDL
Protein: Suppressor of aph-1 (C6KRN1)
Organism: Caenorhabditis elegans
Function: Involved in negative regulation of early and late embryonic Notch signaling.
Interaction partners:
- ATP-dependent RNA helicase cgh-1
- Dynein light chain 1
- Dipeptidyl peptidase family member 2
- Eukaryotic translation initiation factor 4E-4
- F-box/WD repeat-containing protein sel-10
- SWI/SNF chromatin-remodeling accessory subunit 2
Sequence:
MHKNGNNGPVIDTKWHYLGPDSEKYGPYMSKDMLFWLQAGYFNDGLQLKTENEPNYHTLGEWSQLLGTHPFSMPVHSLDATIAQMNSMRPHGAMMMVPPGLQNQFQPPMPMRFPPFLPMPLLHQMNQNGPPMGAQMHSQPPSEPIDAGSLSHTPDSENETRLNEQTLQQPPSWLIALGLAGHGRKPHHHQQILAHQHIPQMQHANVATDQVVMKSVECQTEPVEISKEQASRVLSELLGQMVIIN
Protein: GH18819p (Q95SK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSVSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKIR
Protein: Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) (Q9H4G0)
Organism: Homo sapiens (Human)
Function: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Glutamate receptor 1
- Ezrin
- Radixin
- Moesin
- Plastin-1
- Myosin-9
- Disks large homolog 1
- Band 4.1-like protein 2
- Glutamate receptor 4
- Taperin
Sequence:
MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Protein: TMEM1 family protein, putative (AFU_orthologue AFUA_1G12540) (Q5BEJ2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit BET3
- Trafficking protein particle complex subunit
- Hypercellular protein A
- Trafficking protein particle complex subunit 2/Sedlin, putative
- Transport protein particle
- PutativeTRAPP
- DUF974 domain protein
- Trafficking protein particle complex subunit 11 domain-containing protein
- Uncharacterized protein
Sequence:
MDSLPQAASNSVTVEYTDPSGLFSSVQPIIAHKLPLRNLHWKSPTRPVRSIESLRIGFTPAKTETDERKPSSDAPGGTVTHRRHQIPGLRQTPYLKIYILRCDDNDTYKNSARKALREWIKSHGSSSTSSTAATSQEKHDAFEWLILHVVQDGDGTEKVATSKWGRTTTTVLEKVKADFNGTSKTAIDRVAQLRLPKPGNTQKSPELADQIEDFVEKVKNGILASFDLRVAQYEEDIKEKDSQRSLPGWNFCTFFILKEGLARGFENVGLFEDALVGYDELAVGLDAAIQEQLAGSSEQHGSAFLTYSKDWRERAKAALDAQANVQSPDDGDEVAPISDIDPADFPLDPNRKPYREEILSSNISIFDFRTYVFSRQLTLLLRASRAPSIVSDDADTNQKSGTGKKKPEDLMLLAEVCERATEFISLAARTLRSDLEGGLAEVEHAAKSEVINNLVSSWAYAAASQILVQTFTPALTLPESALHAVDGPEQKQGVPKRTSSLVMPNNRQSRPVKSEMLPSNALSSVHEQVGYEGPKLTPKTGSEQLASGRGELFLLARRFLEEIAGRCGWKETWTDLGLLFDESSESGNMAEIALDDEDSKPTKELQPVNTLKGIDLSQLKEALKSRKAFRAYYEELTDQMYRHHIAANRINSTHTALADMAVLRFRQSDYGAAASYCHQVAPFYGNKSWTILEGVMLEVYARCLKELGRNDEYVRMMARLLAKYAAHTQSRLSTRQKTLDASSIFSEQELLSEYVEELFRAAGELQKEVSAPLTDFFGELDVKPGILHYKDRDGFQLQLHLRFLLGKRIDVDSIKIRLVSANASAQSSECWIETSTKTTIKSSPTKILVDSSTTLQGKYYVDRVETRTGNLLFSMSGGANANLPLGFREDVDEDEDTRSYILCYPPPEGLQARIEAPHLVNLEAMRTLELELNSGWNDIKTGVLRVRPATAGLRLRVTEAEVVEGDIDINANNESGNIEFSHLRPHSVVRCRIPYTVEEHPATLSARAEVTYQTEQGRFSYSSAHNVVSALPISVNVQDVFKQDVLFSRFTVSPATMIPLWLSKCSIPSSDVYEVQSNVGDNVAMRVFPKQPASLLYKIQPRKDIVASPGSRRALRLTVDFTCVDDECFDTVEKTFKESISKSEFAQYTSLLTPHLVEAFRSQLSPPEMEVIGLVREIETLPYAAVRWEGLLSALKEPLDGLRAWLKQWHDNHLILSLPPQPSIRRRHIIIPVDIPEIQVVLTAELRLTNLPSQAPYAAVGQTITAELRLSHTRRWCSPDQRENGDGPLEFSYELHANPDLWMVGGRRRGNFTASEGETRTFAIMLLPQKAGHLLLPGLEIRSFVPSPLQSPSTSAATVAGTGAVAGPGTPGPGHGQNVQVQRRPIGSEVNYRNHGETVLVLPDLRGTTVSLSGGGQGSWLIDSERRVHQPTA
Protein: Vomeronasal 2, receptor 82 (A0A3B2W851)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MLLSWLLIVWFLQMPTFTWIIATHICPTDTKHLIHSDGTVVIGAFFPILHNSRVSKIIDWRYFPMDSDDYFGINARNYQLVLAMLFAVNEINLNSHILPNTSLGLEIYNLPAIGRNIFRTVFSWLTGLSSVIPNYTCRKESKSAATLTGLSWKTSETIWTILDLYKFPQLTFGPFDPVQIDRNQFRSLYQVAPKDTALLSGIASLMLHFNWNWVGLLIPADQRGAQFLSDFRKELDKTRICIAFVQTVLYLGETLLRLLSQDHIHILESSTADVIVIYGPTSILLTLIESTYRKYNMKKIWVMNTKWFCPNIELYNMLELSHGALIFSPHYEEIAGFKKFMQEATPIKYPEDIFLHILWYWYFKCSFLHFECKIFKNCLQNASLELLPGNIFTMTMTEESYYVYNAVYAVAHSLHEETLSQIQYQPQSNIDRTLLFPWQLHPFLKKIQVKNSVGDDVVLDWKRKADPEYDITNIWNFPTGLSLLVKVGTFVPSAPKGKQLSMSEYMINWPIGFTEIPHSVCSESCNPGFRKVALESKPTCCFDCTPCPDNEISNETGEGQVSQRIFHSFYSALTKLSKGKK
Protein: Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] (Q9QVC8)
Organism: Rattus norvegicus (Rat)
Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. May have a protective role against oxidative stress in mitochondria (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17435176, ECO:0000269|PubMed:20133804}. Mitochondrion {ECO:0000250|UniProtKB:Q02790}. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17435176}. Cell projection, axon {ECO:0000269|PubMed:20133804}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (By similarity). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (PubMed:20133804). {ECO:0000250|UniProtKB:Q02790, ECO:0000269|PubMed:20133804}.
Interaction partners:
- Prostaglandin E synthase 3
- Glucocorticoid receptor
- Progesterone receptor
- peptidylprolyl isomerase
- Stress-induced-phosphoprotein 1
- Androgen receptor
- Mineralocorticoid receptor
- Heat shock 70 kDa protein 4
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
Sequence:
MTAEEMKVAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEDEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYYNDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVHLKSFEKAKASWEMNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKAKTEVAAGDHPTDAEMKGEPNNVAGNQAQVKTEA
Protein: Synaptonemal complex central element protein 1 (Q5XHZ2)
Organism: Rattus norvegicus (Rat)
Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9D495}. Chromosome {ECO:0000250|UniProtKB:Q9D495}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. {ECO:0000250|UniProtKB:Q9D495}.
Interaction partners:
- Phenylalanyl-tRNA synthetase subunit alpha
- Testis expressed 12
- Synaptonemal complex protein 1
- Synaptonemal complex central element protein 3
- Six6 opposite strand transcript 1
- Synaptonemal complex protein 3
- HORMA domain-containing protein 1
- Cohesin subunit SA-3
- SPO11, initiator of meiotic double stranded breaks.
- Meiotic recombination protein REC8 homolog
Sequence:
MATRPQPLSVEPEGSADLLHGPEGARGRRGSTQKIEDLMEMVEKLQKVGSLEPRIEVLINRINEVQQAKKKASEELGEAQTVWDTLQKEVDSLHEEKVRLKDILNRKEETLRIMQLHCQEKESEAERKHSMLQECKDRISFLNNQIDNEKAKLRRLRLDFEEHLETLMSQHKDTMEFHKPEHLTEEMSVLDSSKEQLLKEEKLIKAKLEDVQHRLCALCGPEGSSTFSDGLFLRSHEAAAAMQMFKDENKKAEELLEAAAQQHQQLQQRCRQLQQKRQRLKEELEKHGVQILAQIQSTQKEEDSSWRTASPKPLEAHKETVQERPSSRT
Protein: Agamous-like MADS-box protein AGL49 (Q9ZUI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- AGAMOUS-like 102
- AGAMOUS-like 83
- AGAMOUS-like-34
- MADS-box transcription factor family protein
- MADS-box protein AGL73
- At5g26880
- Agamous-like MADS-box protein AGL90
- AGAMOUS-like 94
- Agamous-like MADS-box protein AGL30
- Agamous-like MADS-box protein AGL28
Sequence:
MAPRQKKPNKSDDDDGDLHRKKQSFFKQRFPGFKKKASELSVLCGNSVGFICYGPDNDLHVWPQSQDHNPQALHEIVAKFNALSDERRKNHACDLNDFPHHLKGLSREELRKHLLHLDSQLLGVREQKIEILKKTLTGSSEKDGARVSENSAISDHKLKIEPNLTDILSEDHLIRVSDKKLGSCDVFDELAYVVRGSRNLNENVSNYESKDAAYTGMDHLGTFGGNYLQEAAAELYQTYNLGNFCDDHVWDLEFASRLPPLHTFSDPLMTTNTCQTMSSDMISI
Protein: ATP-binding cassette, sub-family C member 8 (A0A1B0GRD7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XLVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTRLA
Protein: C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (Complement component 1 Q subcomponent-like 1) (O75973)
Organism: Homo sapiens (Human)
Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Adhesion G protein-coupled receptor B3
Sequence:
MLLVLVVLIPVLVSSGGPEGHYEMLGTCRMVCDPYPARGPGAGARTDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKPGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDAASGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD
Protein: Potassium channel subfamily K member 2 isoform X1 (Potassium channel, subfamily K, member 2a) (F1QAI2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Popeye domain-containing protein 1
- Popeye domain-containing 2
- Popeye domain-containing 3.
- Piezo-type mechanosensitive ion channel component.
Sequence:
MRSSENSRSHKVVMAAPDLLDPKSATHNTKPRLSFSSKPIVYNSGDDCESITTVMKWKTVLAIFLLVVLYLIIGATVFKALEQPEEGLQKYRIIQEKIDFLSMHTCVNTSELEDLVKQVVLAIRAGVNPSGHPSNESSMWDLSSSFFFAGTVITTIGFGNVSPHTEGGRIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEKMFVKWNVSQTKIRVTSTVLFILFGCLLFVALPALIFQHIEGWSALESIYFVVITLTTIGFGDFVAGGSEIEYLDYYKPIVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVSAEFKETRRRLSVEIYDKFQRAAYIKRKLSSELGQNPGQDMMPCKRTLSVNFTDELEKEGLPTLTKNGSLYLNGLTPDCPDCSEISIIEHLK
Protein: MNAT1 component of CDK activating kinase (H0YJ92)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
TREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS
Protein: Latent-transforming growth factor beta-binding protein 3 (LTBP-3) (Q9NS15)
Organism: Homo sapiens (Human)
Function: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Subcellular location: Secreted {ECO:0000269|PubMed:12154076}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329}. Note=Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide. {ECO:0000269|PubMed:12154076}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Transforming growth factor beta-3 proprotein
- Growth/differentiation factor 8
- Lysyl oxidase homolog 1
- Protein Wnt-10a
- Latent-transforming growth factor beta-binding protein 1
- A disintegrin and metalloproteinase with thrombospondin motifs 10
- Elastin
- Latent-transforming growth factor beta-binding protein 4
Sequence:
MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
Protein: ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Mel-N1) (Q60899)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs. Seems to recognize a GAAA motif. Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- ELAV-like protein 3
- ELAV-like protein 4
Sequence:
METQLSNGPTCNNTANGPTTVNNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKSRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA