wanglab/gogpt-training-data huggingface dataset:
Protein: RE58581p (Q5BIH1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTMAEGTDPMGHGHHTNPHNPPQQPPQHHPHHLPLPHPPPAPPPQLLNFNHHQQQYLPHMYPAAAAAAQSHSHYGGLQYPHPHALQHQHHPHQHQHHLPLALSLHQQAAAAAAVAAAVATNHSNNNNQASVANNNIVVPWKQRKRKRLSAVLDKLHHNNNNNNNNNNETHSNGMACKAEPMEMKGDLAEDAEQDEDHDGSVPDEEDDSVDQDGDAGKYIKSEQPVSEDEENEQEMDQDIEDISGEDLELSHSDDNDQDDSPRISMSPLQLQAAQINLPQDQNQPMNKENPLHVDIKTEIPSPYDRYFPIPSPLFGYYLHTKYLNEVFRRRHDLYPSPLQHTPSSIASETETSPNAQERKSSSNHVLPHALLANNSPPPSLPSPPRSESSVTNNVATTTTSSTTKKRSSPKPKGKKGEKKPMPPPQERPLDLCMRNEVEPKKYKKSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPASSSHSGHMPITSAATPNHQPPPNSPYANAMNAAHAAAAAAAAAMIKMEMPLHPLHHQQMHHSQVPTTTVGVPVIKGDVASPTTKETVAWRYNLDVSPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRNPANDIAKAYSCDVCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRRDMITRHMRTHTRYDSRGGSREGREGREGREGKESRDSRRSNERIEEPNSPGSHSLLDMKMNMNMGMGMGLNMGLPMNPMSLLQEELLQKSQPGLTLGGPMPLVVKTESA
Protein: H-2 class I histocompatibility antigen, D-P alpha chain (H-2D(P)) (P14427)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MAPRTLLLLLAAALAPTQTRAGPHSLRYFVTAVSRPGLGKPRYMEVGYVDNTEFVRFDSDAENPRMKPRVRWMEQEGPEYWEQETQNAKDHEQSFRVSLRNLLGYYNQSKGGSHTIQGMRGCDVGSDWRLLRGYEQFAYDGPDYIALNEDLKTWTAADMAAQITRRKWEQAGAAETLRAYLEGACVEWLRRYLELGNATLLCTDPPKAHVTHHPRSEGKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAALVVPLGKEQNYTCHVEHEGLPEPLTLRWEPPPSTDSYMVIVAVLVVLGAVFIIGAVVAFVMMMRRNTGGKGGDYTLAPGSQSSEMSLRDCKVMVHDSHSLA
Protein: Velvet complex subunit RYP3 (B2CQK1)
Organism: Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
Function: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Component of the RYP2-RYP3 heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of RYP2 that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Required for viable spore production and regulation of sporulation in response to temperature, as well as for the switch to yeast-form in the presence of host cells.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated by VEL1 (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
Interaction partners:
Sequence:
MYTLKQDRPHPVPPPPPLTMDHLQHGYSTNTPVTLPGIPEAARSVSTVYEGRIYSLDVVQQPIRARMCGFGDKDRRPLTPPPCIRLIVRDATTQKEIDINEIDTSFYVLTVDLWNAEGTSEVNLVRHSATSPSISTATSSAYPPPANIMPFPQYAQTHGYPQTAYPPYYGGQPGYNPHAGYQYPQGGPDPYYPGLPAASTYYPPGTPTQALGPQSALGPHISSASTGMFTRNLIGSLSASAFRLTDPDDKIGVWFVLQDLSVRTEGSFRLKMNFVNVGTQSQAQDQSPGGTPSSPVINVGSAPVLASAFSEVFQVYSAKKFPGVIESTPLSKCFAFQGIKIPIRKDGVKGPRGGQSHGSKGQDGEGEDWENEG
Protein: HIV-1 Tat specific factor 1 (Q5H919)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWFPKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKAESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGE
Protein: Ribosomal protein L24 (C9JNW5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRAAKEAKKAKQASKKTAMAAAKVIMGFLYFLEQYNRKIFFF
Protein: Exosome complex component Rrp42 (O26778)
Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Function: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00622}.
Interaction partners:
- Exosome complex component Rrp41
- Exosome complex component Csl4
- Exosome complex component Rrp4
- DNA primase DnaG
- Conserved protein
- RNA 3'-terminal phosphate cyclase
- Ribosome maturation protein SDO1 homolog
- Pre-mRNA splicing protein PRP31
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein eL8
Sequence:
MVNKMDIIPEITRKSITDLINNKERIDGRSLHEFRDISIETGVISKAEGSSRVKLGNTQIIVGVKPQIGEPFPDTPEMGVILTNSELLPMASPTFEPGPPDERSVELSRVVDRCIRESRMIDLEKLCIIEGSKVWMLFLDLHIIDYDGNLFDAAVLATVAALLDTRIPAAEVEDGEVVINREKMQPLPVNRKALMCTFAKIGNEIVLDPSLEEEDILTARISIGVTEEGSICAMQKGGEGPLTRDDVLKAVSIAVEKVPQLIEYLDKSMTP
Protein: PknH-like extracellular domain-containing protein (O53263)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MVGLTRPLLLCGATLLIAACTRVVGGTASATFGGDRQGMLDVATILLDQSRMQAITGSGDDLTIIPTMDTTYPVDVDDFAQPIPRECRFIYAETAVFGSEIEAFHKTTFQDRPDGSLISEAAAAYRDAGTARRAFDTLAVTVHDCAASPAGWLFVSRWTAGGNSLHIRAGDCGRDYRVLSAALLEVTFCGFPESVSDIVMTNIAANVPG
Protein: Alpha-bungarotoxin isoform V31 (Alpha-BTX V31) (Alpha-Bgt(V31)) (BGTX V31) (Long neurotoxin 1) (P60616)
Organism: Bungarus multicinctus (Many-banded krait)
Function: Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
Subcellular location: Secreted {ECO:0000269|PubMed:3401449}.
Interaction partners:
Sequence:
MKTLLLTLVVVTIVCLDLGYTIVCHTTATSPISAVTCPPGENLCYRKMWCDVFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG
Protein: UPF0462 protein C4orf33 (Q8N1A6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDFKIEHTWDGFPVKHEPVFIRLNPGDRGVMMDISAPFFRDPPAPLGEPGKPFNELWDYEVVEAFFLNDITEQYLEVELCPHGQHLVLLLSGRRNVWKQELPLSFRMSRGETKWEGKAYLPWSYFPPNVTKFNSFAIHGSKDKRSYEALYPVPQHELQQGQKPDFHCLEYFKSFNFNTLLGEEWKQPESDLWLIEKCDI
Protein: NAD(P)H dehydrogenase subunit H (C5MRJ8)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
FCDYFLRGVIEYQQLITQNPIFLERVEGVGFISGEEAVNWGLSGPMLRASGIQWDLRKVDLYESYNQFDWKVQWQKEGDSLARYLVRIGEMRESIKIIQQAVEKIPGGPYENLEVRRFKKAKNSEWNDFEYRFLGKKPSPNFELSKQELYARVEAPKGELGIYLVGDDSLFPWRWKIRPPGFINLQILPQLVKKMKLADIMTILGSIDIIMGEVDR
Protein: Transposon Ty2-DR2 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)] (Q03494)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLHQNPHSQHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQEETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQDQHSEVPQAKTKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYSDILTVLCKSVSKMQTNNQELKDWIALANLEYNGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNSDHINESTVSSQYLSDDNELSLGQQQKESKPTRTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQNNQTKLDQFDYDTLTFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSLNPLQLDKEPVQKVRAPKEVDADISEYNILPSTIRSRTPHIINKESTEMGGTIESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAVCDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTHKSPTDTSDVAKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNKDNKEKDRYVEAYHKEISQLLKMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGEGDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: IQ domain-containing protein F3 (P0C7M6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSKCCKGGPDEDAVERQRRQKLLLAQLHHRKRVKAAGQIQAWWRGVLVRRTLLVAALRAWMIQCWWRTLVQRRIRQRRQALLRVYVIQEQATVKLQSCIRMWQCRQCYRQMCNALCLFQVPESSLAFQTDGFLQVQYAIPSKQPEFHIEILSI
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q8T030)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSVSMSLVQGGAAGGAPQGASAILAAAAPYYQPPAVPQDVQPDRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTGRVPLCINPQSAAFKSFASQ
Protein: Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) (Protein EMBRYO DEFECTIVE 2778) (Protein FLAKY POLLEN 1) (P54873)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation.
Interaction partners:
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Acetyl-CoA acetyltransferase 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- Acetyl-CoA acetyltransferase 2
- 3-ketoacyl-CoA thiolase 5, peroxisomal
- 3-ketoacyl-CoA thiolase 2, peroxisomal
- 3-ketoacyl-CoA thiolase 1, peroxisomal
- Mevalonate kinase
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
Sequence:
MAKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTSLFEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESKLRASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKIEGKEFSINDADYIVFHSPYNKLVQKSFARLLYNDFLRNASSIDEAAKEKFTPYSSLTLDESYQSRDLEKVSQQIAKPFYDAKVQPTTLIPKEVGNMYTASLYAAFASLIHKKHNDLAGKRVVMFSYGSGSTATMFSLRLNDNKPPFSISNIASVMDVGGKLKARHEYAPEKFVETMKLMEHRYGAKDFVTTKEGIIDLLAPGTYYLKEVDSLYRRFYGKKGEDGSVANGH
Protein: NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require) (P59047)
Organism: Homo sapiens (Human)
Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:19192343}. Mitochondrion {ECO:0000269|PubMed:19192343}. Nucleus, nucleolus {ECO:0000269|PubMed:19192343, ECO:0000269|PubMed:25542835}. Cytoplasm {ECO:0000269|PubMed:19192343, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:25542835}. Golgi apparatus {ECO:0000269|PubMed:19192343}.
Interaction partners:
- Oocyte-expressed protein homolog
- Transducin-like enhancer protein 6
- KH domain-containing protein 3
- Inactive protein-arginine deiminase type-6
- Autoimmune regulator
- Growth/differentiation factor 9
- Zygote arrest protein 1
- Zinc finger BED domain-containing protein 3
Sequence:
MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN
Protein: Aprataxin-like protein (EC 3.6.1.71) (EC 3.6.1.72) (Hit family protein 3) (Q08702)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Tyrosyl-DNA phosphodiesterase 1
- DNA ligase 4
- N-glycosylase/DNA lyase
- ATP-dependent DNA helicase II subunit 1
- Flap endonuclease 1
- DNA ligase 1
- DNA topoisomerase 1
- Adenosine 5'-monophosphoramidase HNT1
Sequence:
MSWRYALKNYVTSPETVNDDTVTYFDDKVSIIRDSFPKSECHLLILPRTMQLSRSHPTKVIDAKFKNEFESYVNSAIDHIFRHFQEKFRIKKSDDDKDPCWDDILKDKNKFVRNFVQVGIHSVPSMANLHIHVISKDFHSVRLKNKKHYNSFNTGFFISWDDLPLNGKNLGTDKEIETTYLKEHDLLCCYCQRNFSNKFSLLKKHLELEFNSHFELK
Protein: Large ribosomal subunit protein bL9 (50S ribosomal protein L9) (P9WH79)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Binds to the 23S rRNA.
Interaction partners:
- Large ribosomal subunit protein bL19
- Small ribosomal subunit protein bS18A
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein bL34
- Small ribosomal subunit protein bS6
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL23
Sequence:
MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQKQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVAAIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS
Protein: Meckel syndrome type 1 protein (Q57YX0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
- C2 domain-containing protein
Sequence:
MDFLQFCSSERYVSRVPVHNLSFRITLWRAPLVGERQLEQLCTLTVPWGGKVFSPAERLQKIRTGVAMTTPDSNASTREIHTVVPGRRETDGDAAAAADDVEKLREDIAKFSCTFFTRPPSEDYVSEAKENLLVDPPQAASPHVQIILREHQNQHQEGNRMYFMWASGEILGPSEGKFDDAQWKGQERVICTITAERNSLCFTAKPSLNKTHTLLVDSLYVYSFVITPLQACEPRPDEPTSTDFVEQIHEMVARIKDDLKSPHFDRRGILHQILLQQLHTAPSDELPPRLDSPSSPCFPQSAIRDSRVRYYLFGVVERCTCVAADTLYLHCQWQRGGDNEDEDDKRNLWNEGTLDGFTTQLSFASSMIMDQFIPVSMHTFNTPFDYHFDGWGPSPLRLLITAYDDEGLSVGGPQSPIGYAAVTVPHFLPGCHPLRAPLWRPRPTGREFVRSALMGGGPALVDVRDTAPRGGGGISVKCGLVSEPTGTVELRVTVFHQVGPL
Protein: Selenocysteine Se-methyltransferase (BoSMT) (EC 2.1.1.280) (Q4VNK0)
Organism: Brassica oleracea var. italica (Broccoli)
Function: Catalyzes the methylation of DL- and L-selenocysteine with S-methylmethionine as donor. Methylates also DL-homocysteine, DL- and L-cysteine in vitro. May be involved in selenium detoxification.
Interaction partners:
Sequence:
MVTGNTKAETFYSMKELLKETGGYAIIDGGLATELERHGADLNDPLWSAKCLLTSPHLIHTVHLDYLEAGADIISSASYQATIQGFEAKGYSIEKSESLLRKSVEIACEARSTYYDKCKDDDDKKILKKRPILVAASVGSYGAFLADGSEYSGIYGDLITLETLKDFHRRRVQVLAESGADIIAFETIPNKLEAQAFAELLDEGVAKIPGWFSFNSKDGVNVVSGDSIKECIAIAEACEKVVAVGINCTPPRFIEGLVLEIAKVTSKPILVYPNSGERYDPERKEWVENTGVGNEDFVSYVEKWMDAGVSLLGGCCRTTPTTIRAIHKRLVSRRSLFSSSSSSSHH
Protein: Transcriptional regulatory protein WalR (P37478)
Organism: Bacillus subtilis (strain 168)
Function: Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor histidine kinase WalK
- Two-component system WalR/WalK regulatory protein YycH
- Two-component system WalR/WalK regulatory protein YycI
- Exodeoxyribonuclease YycJ
- Sensor histidine kinase YclK
- Alkaline phosphatase synthesis sensor protein PhoR
- Sensor histidine kinase ResE
- Uncharacterized protein YhcK
- Sensor histidine kinase YkoH
- Uncharacterized serine protease YyxA
Sequence:
MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEELQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTKPFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTHREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNWIVTRRGVGYYLRNPEQD
Protein: Actin-like protein arp10 (O60054)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Note=Localizes at the barrier septum.
Interaction partners:
- Centractin
- F-actin-capping protein subunit beta
- Probable actin-related protein 8
- Actin-related protein 4
- Dynein intermediate chain 1
- SWI/SNF and RSC complexes subunit arp42
- Actin
- F-actin-capping protein subunit alpha
- Microtubule-associated protein ssm4
- Actin-related protein 3
Sequence:
MRKNCDISTVVVQIDEFGIYIGNASDKEPTWKVDLVPYKQSWVPISIVTTIIQRYCLNTFNCLAEIVRVVLVLDIFVTRKQKKELCDGLFNTLNVPITLWICAPLTAILSTSTRDAIIVDIGMKETKFIVILDLCILMHYTKTSKRSLSTVLERMADCFKLNNKKNSQKLLEDEEFAVTEALMKSLLKSRVPSKPTEELYQLTDQEAYFRYSDILPLAETTCQTNKTERGSSFNDAEKIRVPSWIANAGIEALFEGSDAGGSDIADQALPNVLLSLYRILPIDIRRIMSKLIVFNGILPSLPGWYQRFQNEMTSRGLAIKAVPGQTTADMMAWNGASTTCESQLDYDPDDPKHLRHSIVESPLLYGQDQYFNGENAPEWW
Protein: Aminopeptidase puromycin sensitive (A0A8I5XWV8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MWLAAAVPSLARRLLLLGSPPPPLLLLLSRSSSRRRRLHSLGLAAMPEKRPFERLPTEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLESASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLLHKQADMQEEKNRIERVLGATLSPELIQKVLTFALSMSAAPLCGQCAH
Protein: Taste receptor type 2 member 123 (T2R123) (STC9-2) (Taste receptor type 2 member 23) (T2R23) (mT2R55) (P59528)
Organism: Mus musculus (Mouse)
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MFSQKINYSHLFTFSITLYVEIVTGILGHGFIALVNIMDWVKRRRISSVDQILTALALTRFIYVLSMLICILLFMLCPHLPRRSEMLSAMGIFWVVNSHFSIWLTTCLGVFYFLKIANFSNSFFLYLKWRVKKVILIIILASLIFLTLHILSLGIYDQFSIAAYVGNMSYSLTDLTQFSSTFLFSNSSNVFLITNSSHVFLPINSLFMLIPFTVSLVAFLMLIFSLWKHHKKMQVNAKQPRDVSTMAHIKALQTVFSFLLLYAIYLLFLIIGILNLGLMEKIVILIFDHISGAVFPISHSFVLILGNSKLRQASLSVLPCLRCQSKDMDTMGL