wanglab/gogpt-training-data huggingface dataset:
Protein: ATF6B protein (cAMP responsive element binding protein-like 1) (Q96QL7)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
Sequence:
MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVSPSTTVLLQSLVQPPPGTEEGEKGRAWWLTPVIPALWEAEAGESPEVRSLRPAWPTW
Protein: Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) (O74990)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H9E3}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 5
- Protein sly1
- Vacuolar protein sorting-associated protein 53
- Vacuolar protein sorting-associated protein 54
- Integral membrane protein sed5
Sequence:
MDISINDCTDISQIKQRFHDLQVESQRTDEKLERLLSDAQPTEKFNSLIKNMAERLVLFVGQIEELKDAFCNTTIVSEEVIERIKSVDREQNRIKECLLFVRQVRDFKECLQDLNRAMHHQQWEKAADLVHRASSTSPAIIEGKFAHAVVPTAEQPLAPMDTLKEITESLHTLFWREFHKAARNQDQKEITRYFKLFPLIGKEKEGLEAYWHFFGGIIASKARATLDEPPTHALFFAQAFTGLVEHVASIIRAHTPLVQKYYKAKNTITVIEKLQGDCDRQGSIIVNTMFDVRRIDNLVSSIASYKYILLHAKLKNRAFVSDQKELERVSLQTLHPILNEMSAIVSKWNISKIFISRLVLRLSQSDGTSNDPSVQDNLICASIFNSSKMELLLKKQLLPSLLQLETYYFRRSIETSLELEEYYTKVSPWMSSIVDDVMYVTKQVFQRAFFTVSSLFFTRFVNESLIPILRNDYYVYLSHNLLTVCNIIKAQFQRLKNANSIPAKQVENYITLVNSASLSKQYLKSIVDGVSSRLEEVFAFAKDQKLVKKSIDNFLQLTVNFENLCKTSFNMYFPIFLLPRIEQCIDDSFDGINYVLSYEDYTKETEHERLVVTRLRSVWDRVLLLEQFTPENQLSLRSMACEKAASYIENLILYKIQWNDYGAMALENDISSLITIFSNDQANLRHSFERLQEILILLVWESDSTAPEQLINDLNLQLLSIDIVSAIMEKKANVQGED
Protein: Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17] (O00230)
Organism: Homo sapiens (Human)
Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Subcellular location: Secreted.
Interaction partners:
- Mas-related G-protein coupled receptor member X2
- Somatostatin
- Somatostatin receptor type 1
- Somatostatin receptor type 2
- Somatostatin receptor type 5
- Somatostatin receptor type 4
- Somatostatin receptor type 3
- Fanconi anemia group M protein
- Centromere protein S
- Growth hormone secretagogue receptor type 1
Sequence:
MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK
Protein: 2'-deamino-2'-hydroxyneamine transaminase (EC 2.6.1.94) (Kanamycin biosynthesis protein B) (Neamine transaminase KanB) (EC 2.6.1.93) (Q6L741)
Organism: Streptomyces kanamyceticus
Function: Aminotransferase that has 6'-oxoglucosaminyl:L-glutamate aminotransferase activity by catalyzing pyridoxal-5'-phosphate-mediated transamination leading to the conversion of paromamine to neamine in the biosynthetic pathway of kanamycin B.
Interaction partners:
Sequence:
MSTHPVLDWSRSAEHLRRSHGVTTDPRPDEDGHYPCVLTRGSGTRVYDLDGNAYLDLTGSFGSVLIGHAEPAVVRAVTDVLSEGNLFYTGASPRRLALAERLLDWFPWSEQAIFYRTGSCAVSAAARLAQHATGRNRVLSSGYHGWHDWHLEAVPEAKPKTFESYATEFHNDLALYRSWLDRHGEEIAAVVVTPEPHRFDHAYYQELREVAKEHGCLFVVDEVKTGFRAGAGGFSALAGIEPDAVTVSKGMANGHSISAVVGQRQLTQELSEAHVWSTYQNEQVGFAAALASLDFLERHDVAAVTRRTGEAVRQGVLQLFAEHGLPVGAPGWGPMFELDFDAADEGLAERLEAALLRHGIFCDTGDDFNMMFHTAEHTDELLERFAAALGDL
Protein: KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor) (Q969F8)
Organism: Homo sapiens (Human)
Function: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Metastasis-suppressor KiSS-1
- Guanine nucleotide-binding protein G
- Gonadotropin-releasing hormone receptor
- Progonadoliberin-1
- Tachykinin-3
- Beta-arrestin-1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Beta-arrestin-2
- Prokineticin-2
- Guanine nucleotide-binding protein subunit alpha-11
Sequence:
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
Protein: Solute carrier family 15 member 4 (Peptide/histidine transporter 1) (rPHT1) (O09014)
Organism: Rattus norvegicus (Rat)
Function: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity).
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q8N697}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q8N697}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91W98}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEGERAPLLGSRRAAAAAGVFAGRRAACGAVLLAELLERAAFYGVTANLVLFLNGAPFNWEGAQASQALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPRSRSFLCGDPHPELVRNCSAPFPNGTAVCPDAAARRCAPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFLTGYLIPTVCVAIAFLVFLCGQSVFITKPPDGSAFTDMFRILTYSCCSQRGGQRRSGEGLGVFQQSSKHSLFDSCKMSRGGPFTEDKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLKIPEISSITTTHHTLPAAWLTMFDAVLILLLIPLKDKLVDPVLRRHGLLPSSLKRIAVGMFFVTCSAFAAGILESKRLDLVKEKTINQTIGGVVYHAADLPIWWQIPQYVLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGIGSFVGSGLLALVSLKAIGWMSSHTDFGNINSCHLHYYFFLLAAIQGATLLLFLIVSVKYDRQRARTDGGTASTRT
Protein: RELA proto-oncogene, NF-kB subunit (F7F7J5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPATLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Protein: Abscisic acid receptor PYL6 (ABI1-binding protein 5) (PYR1-like protein 6) (Regulatory components of ABA receptor 9) (Q8S8E3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) in an ABA-independent manner but more efficiently when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA. May link ABA and jasmonate signaling pathways by modifying MYC2 transcriptional activity, and regulation of JAZ6 and JAZ8 gene expression by MYC2.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9FLB1}. Nucleus {ECO:0000269|PubMed:25465408}. Cell membrane {ECO:0000269|PubMed:25465408}. Nucleus {ECO:0000269|PubMed:27357749}. Note=Localizes at the plasma membrane in the presence of a CAR protein (e.g. CAR1 and CAR4). {ECO:0000269|PubMed:25465408}.
Interaction partners:
- Protein phosphatase 2C 16
- Transcription factor MYC2
- Protein phosphatase 2C 56
- Protein phosphatase 2C 77
- Protein phosphatase 2C 37
- Probable protein phosphatase 2C 78
- Protein phosphatase 2C 3
- Probable protein phosphatase 2C 75
- Probable protein phosphatase 2C 24
- Protein phosphatase 2C 7
Sequence:
MPTSIQFQRSSTAAEAANATVRNYPHHHQKQVQKVSLTRGMADVPEHVELSHTHVVGPSQCFSVVVQDVEAPVSTVWSILSRFEHPQAYKHFVKSCHVVIGDGREVGSVREVRVVSGLPAAFSLERLEIMDDDRHVISFSVVGGDHRLMNYKSVTTVHESEEDSDGKKRTRVVESYVVDVPAGNDKEETCSFADTIVRCNLQSLAKLAENTSKFS
Protein: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (AtCoaD) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (Q9ZPV8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4'-phosphopantothenoylcysteine as a substrate.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53332}.
Interaction partners:
- Dephospho-CoA kinase
- Phosphopantothenoylcysteine decarboxylase
- Pantothenate kinase 1
- Pantothenate kinase 2
- Probable phosphopantothenoylcysteine decarboxylase
- Phosphopantothenate--cysteine ligase 1
- Alkaline-phosphatase-like family protein
- Phosphopantothenate--cysteine ligase 2
- Glutathione S-transferase T3
- Pre-mRNA-processing protein 40C
Sequence:
MAAPEDSKMSPANSFGAVVLGGTFDRLHDGHRMFLKAAAELARDRIVVGVCDGPMLTKKQFSDMIQPIEERMRNVETYVKSIKPELVVQAEPITDPYGPSIVDENLEAIVVSKETLPGGLSVNRKRAERGLSQLKIEVVEIVSDGSSGNKISSSTLRKMEAEKASKQKQPAEEKAS
Protein: Nuclear receptor coactivator 3 (EC 2.3.1.48) (Retinoid X receptor-interacting coactivator xSRC-3) (O57539)
Organism: Xenopus laevis (African clawed frog)
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as retinoids (RAR and RXR), thyroid hormone (TR) and orphan nuclear receptor (hepatocyte nuclear receptor 4 (HNF4) and constitutive androstane receptor (CAR)). Displays histone acetyltransferase activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Note=Mainly cytoplasmic and weakly nuclear. {ECO:0000250}.
Interaction partners:
Sequence:
MSGLGENSLDPLASETRKRKPSSCDTPGPGLTCSGEKRRREQESKYIEELADLISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKASSNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLYVVNREGSIVFVSENVTQYLQYKQEDLVNTSVYSILHEEDRKDFLKNLPKSTVNGVPWFSETPRQKSHTFNCRMLVKTSHDHLEDGSNLDARQRYETMQCFALSQPRAMIEEGEDLQSCMICVARRITTAERAFSANPESFITRHDLTGKVVNIDANSLRSSMRPGFEDTIRRCIQRFLFHSEGQPWTYKRHYQEAYVHGLSETPLYRFSLADGTMVTAQTKSKLFRNPVTNDPHGFVSTHFLQREQNGYRPNPNPMAQGIRPQMNPNLPNTMNSMPPQAMQQQNRNYGMGDPNSMAQMQGMRYKSPGNMAPVNQAPGVQQSPYQNNSNYGLNMNSPPHGSPGMNANQPNLMVSPRNRASPKMASNQFSPVPGMNSPMGSSGNAGGGSFSSSSLSALHAISEGVGSSLLSSLSSPGQKVENNSNMNMPQQGKICNQDCKSPSGLYCEQGQVESSVCQSSGREHLGEKDVKENIFEGSESQRSQAESKGHKKLLQLLTCFTEERGQSLMSSSSMDCKDSSNVTSPSGVSSSTSIGVSSTSNLHGSMLQEKHRILHKLLQNGNSPAEVAKITAEATGKDVFQETVSSAPCTEATVKREQLSPKKKENNALLRHLLDKDDWKDPLAKDIKPKVEHMDIKMGSCSSSNVPTSSQDKEVKIKTEPGEEVPGDLDNLDAILGDLAGSDFYSNSMSSRASDLGPKQPVFQDSPTLAMRSPDSMQGSRPPFNRAMSLDSRSSTPPVRNVNSFPMLPKQGMIGSPRMMDGQDNFGVMMGSGPNRSMNQHPGGDWAMQNSAVNRLEPPNVGSVGRPGPDYSSAMTRPAMGGNMPGLLTRSNSIPGSRPVMQQQQHILPMRPNDMAMSMGSNPYGQQAPSNPPGSWPDAIMMNQGRGGAQNRQLGRNSLDDLLCPPSTVEGQTDEIALLDQLHTLLSNTDATGLEEIDRALGIPDLVSQGQALEPQPDSYQPQGSPVMIDQKPPMYGQHYAGQGAAMSAGGFNNMQGQHPPFNTVMGQMNQQQGMHPLQGMHPRANLIRPRNNIPKQLRMQLQQRLQGQQFLNQNRQALEMKVDPMNPGGAGVMRPVMQTPVSQQGFLNAQMVAQKNRELISHQIRQHRMAMMMQQQQGQPQAFSPPPNVTASASMDNPLGGPPMPQAPPQQFSYPPNYGINQQTDPTFGRVSSPPNAMMSSRMAPSQNPHPQTTQMYPSPDMKGWPSGNMARPNSFPQQQYSHQTNPATYNMMHMNGNGNHMGQMNINSLPMSGMPMGPDQKYC
Protein: Reduced expression 2 (A2AWF2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Zinc finger protein 600
- 1,5-anhydro-D-fructose reductase
Sequence:
MFAPHQESGRRTTKRMSASLENTAQCLLTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFVENHCICGNYEKEKVLEQDTQHIVNEHGHNRKKSSKCNELRNVIHESSESTPYNTNHRDATLQSSNLKRHKTGTTKGVCTYKDCVNCLKGSSIISLNQGTHIEKKEHNRNKNLDEVLVSRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYKYSESDKCFTQTSHLSIHHTIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSIHRRIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCSECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSECDKCFTDKGSLRVHQRIHIGEKPYKCSECDKCFTQPSHLSIHCRIHSGEKPYKCSECDKCFTHKGSLRVHHRIHAGEKPYKCSECDKCFTEKNGLRRHQRIHTGEKPYKCSECDKCFTRKSHLSIHQRIHTGEKLYKCSECDKCFTQQCHLSIHQKIHSGENLTNAMNATNALVTNTV
Protein: histidine kinase (EC 2.7.13.3) (Q9I3B1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- HPt domain-containing protein
- histidine kinase
- GGDEF domain-containing protein
- ABC transporter substrate-binding protein
- histidine kinase
- histidine kinase
- histidine kinase
- Response regulator GacA
- histidine kinase
- histidine kinase
Sequence:
MSQRHGWDIRTRMLAISLGPALLLTLLLTAYFTYSRLQDLRQELTHTGQLIADQLAPAAEYGVIAGNTPVLQKLLQATLDTPHVRFIEVRDRNDNILVYVEQLSGALQNAAPIDIFHSTIQRQRIALASDPLLDGASEGDGQSGEDYLGRVVVGMSNDAFSQRQQEILLKAALLAAFALILTFLVARRLAQRLSAPISTMGQAVEAIQSGDYKTSLPILDDGEIGDLARHINNLASGLDRASREQEQAIGQLISAREEAEQANRAKSDFLAMMSHELRTPMNGVLGMLQLLETTEQTREQAEYTALATESTEHLLKVINDILDFSRIERGALELECIPFNLLELVQGSALVFQHSAQQRGLALELQIQAGLENIEVCGDPTRIRQILVNLLGNALKFTEEGAIHLSLEWQALDHDVLWLTCAVHDSGIGISPERLEHMFDAFQQADSSISRRYGGTGLGLAIARTLAERMGGTLQAESKEGSGSTFTLEIPLPFQQSPAHRQQAAGDAAPVAAGQEILLVEDNPVNQTVIEAMLRSLGYRVTLVADGIQAVRSAERQRYDAILMDCRLPVLDGYSATREIRAQENGRRVPIIALTANALQGDRENCLQAGMNDYLAKPFKRAELQRILQRWIGSQPELPVTSNETGRGEPE
Protein: Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) (Q9Y606)
Organism: Homo sapiens (Human)
Function: Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:17056637, ECO:0000305|PubMed:15772074}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:17056637, ECO:0000305|PubMed:15772074}. Cytoplasm {ECO:0000305|PubMed:15772074}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit DKC1
- Tyrosine--tRNA ligase, mitochondrial
- Pseudouridylate synthase TRUB1
- Pseudouridylate synthase 7 homolog
- tRNA
- Pseudouridylate synthase TRUB2, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim10
- Pseudouridylate synthase RPUSD2
- tRNA pseudouridine synthase Pus10
- Pseudouridylate synthase PUS7L
Sequence:
MGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD
Protein: Yos1-like protein (Q38D93)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGFSLAGILQALLLCLNAMAILSERRLLSRYGLASSAVMDSSDIGSETAFSSGDELAGVPRQRPFRESIAALLSSVRTLMRWPLIFINTAVIVFTLLFG
Protein: Pyridoxal 5'-phosphate synthase subunit pyroA (PLP synthase subunit pyroA) (EC 4.3.3.6) (Pdx1) (Q9UW83)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
Interaction partners:
- glutaminase
- pyridoxal kinase
- Orotidine 5'-phosphate decarboxylase
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
- GTP cyclohydrolase II
- Transaldolase
- Transketolase
- Ribokinase
- Transaldolase
- Ribose-phosphate pyrophosphokinase
Sequence:
MAATNGASNDFTVKAGLAQMLKGGVIMDVVNAEQARIAEEAGAAAVMALERVPADIRAQGGVARMSDPSMIKEIMEAVTIPVMAKARIGHFVECQILEAIGVDYIDESEVLTPADNLYHVTKHNFKAPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRTVNAEIARARAILQSSPDPEPELRAYARELEAPYELLREAAEKGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAKKRAKAIVQAVTHYKDPKVLAEVSQGLGEAMVGINVSHMKDEDKLAKRGW
Protein: Splicing factor U2AF 50 kDa subunit (U2 auxiliary factor 50 kDa subunit) (U2 snRNP auxiliary factor large subunit) (Q24562)
Organism: Drosophila melanogaster (Fruit fly)
Function: Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Splicing factor U2af 38 kDa subunit
- U1 small nuclear ribonucleoprotein 70 kDa
- Splicing factor 3B subunit 1
- Probable small nuclear ribonucleoprotein G
- Branchpoint-bridging protein
- Splicing factor 3B subunit 3
- LD40489p
- Small nuclear ribonucleoprotein F
- Probable small nuclear ribonucleoprotein Sm D2
- Probable U2 small nuclear ribonucleoprotein A'
Sequence:
MGYDDRERDRERRRHRSRSRDRHRERSRDRRHHRNSRRKPSLYWDVPPPGFEHITPMQYKAMQASGQIPASVVPDTPQTAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAAGSPVLACQINLDKNFAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHDYQPMPGITDTPAIKPAVVSSGVISTVVPDSPHKIFIGGLPNYLNDDQVKELLLSFGKLRAFNLVKDAATGLSKGYAFCEYVDLSITDQSIAGLNGMQLGDKKLIVQRASVGAKNAQNAANTTQSVMLQVPGLSNVVTSGPPTEVLCLLNMVTPDELRDEEEYEDILEDIKEECTKYGVVRSVEIPRPIEGVEVPGCGKVFVEFNSVLDCQKAQQALTGRKFSDRVVVTSYFDPDKYHRREF
Protein: Dynein assembly factor with WD repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) (Q1LV15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis.
Subcellular location: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q3Y8L7}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q3Y8L7}. Note=Expression is concentrated at the flagellum basal body but is also detected along the length of the flagellum. {ECO:0000250|UniProtKB:Q3Y8L7}.
Interaction partners:
- Intraflagellar transport protein 46 homolog
- PRP3 pre-mRNA-processing factor 3 homolog
- Pre-mRNA-processing factor 8.
- Pre-mRNA-processing factor 6
- U4/U6 small nuclear ribonucleoprotein Prp31
- IQ motif-containing with AAA domain 1.
- Activating signal cointegrator 1 complex subunit 3
- U6 snRNA-associated Sm-like protein LSm8
- Spliceosome-associated factor 1, recruiter of U4/U6.U5 tri-snRNP
- Elongation factor Tu GTP-binding domain-containing 2.
Sequence:
MRLKRMHIRYYPPGIFLDYEKGGQLRTKCIDLLNLTPETDVEELVLEIRAAEPLITSSCVEQVKLLICKLQEKVGQKDERKFYLFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITGSKDNTCRIWH
Protein: Solute carrier family 4 (anion exchanger), member 1, adaptor protein (E9PX68)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MADPTPQLDAPAPQEVSSEFKKPVLPVPSAVRGKAPASSPSVSEDVKKECLAAQLDSGCEEPEVPPPQPDSQETGGPPVEQLRSPRVAPASGGPTRAPPYREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRLASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLGEDSDEEEEANTTEGKSSRSGQDDELGCTWGMGEDAVEDEAEENPIALDFQQDREAFYIKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMVQCSLEACRVLDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLVEKKRLNRMKKAGKLDEKPETFESLVAKLNDAERELAEISERLKASSKVLSEPSSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKLVKPAEIPELKKTELQTTNAENKTKKLALPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPALMQMKDEPEVEEEEEEEEEEEEKVKEEHEERVEDGGVRLLQEPELELEAAVEHPSAPSEPSCSKETKSHESISQLSQVEQSKDYQEMGKIVSSCEDPSAAPANEYKQDRDEPKKKKSPGPGKFPPILSSKYPEDDPDYCIWVPPEGQSGDGRTHLNDKYGY