wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Translation initiation factor eIF3 p33 subunit homolog) (eIF3 p33 homolog) (P78795)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
Interaction partners:
- Probable eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit A
- Probable eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit B
Sequence:
MSSSKSLDWADDEDYGTGLPSIQTFDNPDGTKTMIEFRIDDNGKKVKVTRVIRKTVITERVQHAVAERKKWKKFGKEAGKNSGVDARTTSVGENVQLRLQLGWTTTKEEEQDEAALAAAKVKAKGSSVVRCRACKGNHFTAQCPYKSIIGPVDEPPLDASPVSSRASGALGEKGRYIAPHLRAGSGRESGDSMFKRERDDSATLRVTNLSDDTREEELRDLFRRFGGIQRVYLAKDKETGRAKGFAFVSYYDRDCAIKARDRLDGYGWNNLILRCEFSKPRD
Protein: Protocadherin gamma B1 (Protocadherin gamma subfamily B, 1) (Q91XX8)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MENQVLLHFLVPLFCGALSQPIHYSIPEELAKGSLVGSLAKDLGLSIQELPARKLRVSAEDYFSVSAESGDLLVSGRIDREKICGRKSECALEFESVTENPMNIFHVTVAIQDINDNAPHFFGKSIELEICESALAGAKFPLDSARDADVGSNSLKMYTVSPNPHFSLSTKESPDGSKYPELLLETPLDREHQSSHHLILTAMDGGDPPLSSTTQVWIKVTDANDNAPVFSQDTYKVSLRENIPPGTLVLQVTASDQDESIHGEITYAFLNAPASTNLVFNLNPNTGAITTNGTLDFEEKNRYTLGVEAKDGGVHTAHCNVQIEILDDNDNAPEVTFMSFSNQVPEDSVLGTVIALIKVRDKDSGQNGLVACHIQEELPFKLQPTSKNYYKLVIDKALNREQTPEYNVTITATDSGKPSLSSKTCVTVHITDINDNAPVFHQASYLVHVAENNPPGASIAQVSASDPDLGSNGLISYSIIASDLEPRALSSFVSVNQDSGVVFAQRAFDHEQLRSFQLTLQARDHGSPTLSANVSMRVLVGDRNDNAPRVLYPTLEPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGEVRTARALGDRDSARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDDPLPSDPQSELQFYLVVALALISVLFLLAVILAIALRLRHSSRSAAWGCFQPGLSLKSQPVVPPNYNEGTLPYSYNLCVASHSTTMAGFNFHHVAPEVAPPQDLLCDDPSVVVCGNNEDPQVSDDSAFQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: SDO1-like protein C21C3.19 (Q9P7K6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in RNA metabolism.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized transporter C794.04c
- Uncharacterized amino-acid permease C794.03
- UPF0039 protein C11D3.02c
- SET domain-containing protein 3
- Stress response protein ish1
Sequence:
MSSSKANQTRVCYQPEDTTFIIIASNGPDVMRWRKDKTVPLTEIVDSFQVFTTSNNKGNEGQLITASKQELENTFGTSKDVDVVTKILTDGKIIPHREHGKHKEVN
Protein: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) (EC 3.6.1.41) (A0A0H2URF8)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MSYQDYINCSREALLEKMAELLPEKRLTHCLGVERAAMELAQRFGVDVEKASLAGLLHDYAKKLSDQEFLVLIDRYQLDPDLKNWGNNVWHGMVGIYKIQEDLDLHDSEILRAIEIHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIASLSLNKAVAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKED
Protein: Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (P70371)
Organism: Mus musculus (Mouse)
Function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}. Chromosome, telomere {ECO:0000250|UniProtKB:P54274}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P54274}. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (By similarity). Interacts with TRIOBP isoform 1; mediates TERF1 localization to the centrosome (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P54274}.
Interaction partners:
- TERF1-interacting nuclear factor 2
- Protection of telomeres protein 1
- Protection of telomeres protein 1
- Telomeric repeat-binding factor 2-interacting protein 1
- Telomeric repeat-binding factor 2
- Tripeptidyl-peptidase 1
- Poly [ADP-ribose] polymerase tankyrase-1
- Nuclear protein 2
- Adrenocortical dysplasia protein
- Poly [ADP-ribose] polymerase tankyrase-2
Sequence:
MAETVSSAARDAPSREGWTDSDSPEQEEVGDDAELLQCQLQLGTPREMENAELVAEVEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRDSAEAIIHGLHRLTAYQLKTVYICQFLTRVASGKALDAQFEVDERITPLESALMIWNSIEKEHDKLHDEIKNLIKIQAVAVCMEIGSFKEAEEVFERIFGDPEFYTPLERKLLKIISQKDVFHSLFQHFSYSCMMEKIQSYVGDVLSEKSSTFLMKAATKVVENEKARTQASKDRPDATNTGMDTEVGLNKEKSVNGQQSTETEPLVDTVSSIRSHKNALSQLKHRRAPSDFSRNEARTGTLQCETTMERNRRTSGRNRLCVSENQPDTDDKSGRRKRQTWLWEEDRILKCGVKKYGEGNWAKILSHYKFNNRTSVMLKDRWRTMKRLKLIS
Protein: Interferon gamma (IFN-gamma) (C8CLK2)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR001936}.
Interaction partners:
Sequence:
MTCQTYNLFVLSVIMIYYGHTAGSLNLVQLQDDIDKLKADFNSSHSDVADGGPIIVEKLKNWTERNEKRIILSQIVSMYLEMLENTDKSKPHIKHISEELYTLKNNLPDGVKKVKDIMDLAKLPMNDLRIQRKAANELFSILQKLVDPPSFKRKRSQSQRRCNC
Protein: DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) (Q8WV16)
Organism: Homo sapiens (Human)
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4A
- Cullin-4B
- DDB1- and CUL4-associated factor 12
- DDB1- and CUL4-associated factor 5
- DDB1- and CUL4-associated factor 6
- E3 ubiquitin-protein ligase RBX1
- DDB1- and CUL4-associated factor 8
- DNA damage-binding protein 2
- DDB1- and CUL4-associated factor 15
Sequence:
MNKSRWQSRRRHGRRSHQQNPWFRLRDSEDRSDSRAAQPAHDSGHGDDESPSTSSGTAGTSSVPELPGFYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEMESKRLRLLQEEDRRKKIARMGFNASSMLRKSQLGFLNVTNYCHLAHELRLSCMERKKVQIRSMDPSALASDRFNLILADTNSDRLFTVNDVKVGGSKYGIINLQSLKTPTLKVFMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVNSHPGIDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLLTNVVTGHRQSFGTNSDVLAQQFALMAPLLFNGCRSGEIFAIDLRCGNQGKGWKATRLFHDSAVTSVRILQDEQYLMASDMAGKIKLWDLRTTKCVRQYEGHVNEYAYLPLHVHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSPYPASKADIPSVAFSSRLGGSRGAPGLLMAVGQDLYCYSYS
Protein: Vomeronasal 2, receptor 82 (G3UWA2)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Vomeronasal type-1 receptor
- Vomeronasal type-1 receptor
- Vomeronasal type-1 receptor
Sequence:
MLLSWLLIVWFLQMPTFTWIIATHICPTDTKHLIHSDGTVVIGAFFPILHNSRVSKIIDWRYFPMDSDDYFGINARNYQLVLAMLFAVNEINLNSHILPNTSLGLEIYNLPAIGRNIFRTVFSWLTGLSSVIPNYTCRKESKSAATLTGLSWKTSETIWTILDLYKFPQLTFGPFDPVQIDRNQFRSLYQVAPKDTALLSGIASLMLHFNWNWVGLLIPADQRGAQFLSDFRKELDKTRICIAFVQTVLYLGETLLRLLSQDHIHILESSTADVIVIYGPTSILLTLIESTYRKYNMKKIWVMNTKWFCPNIELYNMLELSHGALIFSPHYEEIAGFKKFMQEATPIKYPEDIFLHILWYWYFKCSFLHFECKIFKNCLQNASLELLPGNIFTMTMTEESYYVYNAVYAVAHSLHEETLSQIQYQPQSNIDRTLLFPWQLHPFLKKIQVKNSVGDDVVLDWKRKADPEYDITNIWNFPTGLSLLVKVGTFVPSAPKGKQLSMSEYMINWPIGFTEIPHSVCSESCNPGFRKVALESKPTCCFDCTPCPDNEISNETGMDQCVHCPETHYASAEKRHCLKKTITFLSYNDPLGKGITLLSIGFSTLTALVIWVFVEHRGTPIIKANNRSLSYILLITLILCFLCPLLFIGLPNTATCIMQQYMFGLLFTVALSTVLAKTITVVMAFKITAPGRKIRWLLTSQVPKFVIPVCILIQVLLSGIWLGTSPPFIDKDYQSEHGHIIILCSKGSYIYFYCTLAYLGVMAFGSYLLAFLSRRLPDRFNESKSLAFSMLVFCSVWVMFLPVCHSTSGKVMVAMEMFSILASSASILIIVFAPKCYIVLFRPELNTLTHNRDKRHHRSKTLLKT
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q5PRB2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
Sequence:
MSVKHVLSRGLELGRSVFQLGLLKPAGRVAAKFRGERLRVSRPTRTVQPQTFLPGRYRFFRLSVSGLAAQLQSGAFRRVIGGGSARNRAVFLAFGVGLGLIEQEQEEDRTSAALCQEIQAVFRKKKFQSLPKPFTSGYRLEDYVIGKQIGKGCNAAVYEAAAPFAPPVESKKCSLVELNQKEAEDDNKKEEPLRLSASPSFPLAMKMMWNIGAGSSSDAILRSMSMELVPSCPQALRKEQGELTLNGHFGAVPKRLSAHPNVITVYRAFTAEVPLLPGAREEYPDVLPTRLNPHGLGSNRTLFLVMKNYPCTLRQYLEVCVPKRTQASLMFLQLLEGVDHLCRQNIAHRDLKSDNILLEFDNTGCPRLVITDFGCCLAEDSGLKLPFSSWWVNRGGNSCLMAPEVSTAVPGPGVVIDYSKADVWAVGAIAYELFGQPNPFYTLESRSYQEKQLPALPAAAPDDVQLVVKLLLRKNPHKRPSARVAANILHISLWGRRVLMGLDKVQMAEMMAWLQCQSAVVLLKGRGRDQSSVEAELQRSFLANIELEDLRTAVSFMTYERKQWRSLLMSNTQP
Protein: Galactoside-binding soluble lectin 13 (Galectin-13) (Gal-13) (Placental tissue protein 13) (PP13) (Placental protein 13) (Q9UHV8)
Organism: Homo sapiens (Human)
Function: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29343868}. Nucleus matrix {ECO:0000269|PubMed:29343868}.
Interaction partners:
- Pappalysin-1
- Placenta growth factor
- Uridylate-specific endoribonuclease
Sequence:
MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGNHVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSFVKMVQVSRDISLTSVCVCN
Protein: Eukaryotic translation initiation factor 4 gamma 2 (H0Y3P2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
Protein: Probable conserved transmembrane protein (P96408)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable conserved membrane protein
- Alpha-
- Succinate-semialdehyde dehydrogenase [NADP
- Probable integral membrane acyltransferase
- Uncharacterized methyltransferase Rv0224c
- Membrane protein Rv1476
- Probable conserved transmembrane protein
- Possible conserved protein
- Alpha-
Sequence:
MRWFRPGYALVLVLLLAAPLLRPGYLLLRDAVSTPRSYVSANALGLTSAPRATPQDFAVALASHLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQFVAITLAIWNPYVAERLLQGHWSLLVGYGCLPWVATAMLTMRTTVGAGWFGLFGLAFWVALAGLTPSGLLLAATVAVVCVAMPGAGRPRWQCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVAIGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRDGQKWVALAVPGYTLSGAGTVLTLRRWLRPATAAVVCCLALVLTLPDLAWGVWGKVAPVHYPSGWAAVAAAINADPRTVAVLPAGTMRRFSWSGSAPVLDPLPRWVRADVLTTGDLVISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRLAAAHRDDELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLHHCEDTPASRAQD
Protein: Polybine-1 (Polybine-I) (P84388)
Organism: Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
Function: Venom component which lacks hemolytic or antibiotic properties, but produces an inflammatory response via mast cell degranulation and produces a chemotactic effect on leukocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:15572194}.
Interaction partners:
Sequence:
SADIVKKLWDNPAL
Protein: Probably inactive leucine-rich repeat receptor-like protein kinase IMK2 (Protein INFLORESCENCE MERISTEM RECEPTOR-LIKE KINASE 2) (Q9SCT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754, ECO:0000269|Ref.6, ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754, ECO:0000269|Ref.6, ECO:0000305|PubMed:17644812}.
Interaction partners:
- Ankyrin repeat-containing protein At5g02620
- Kinesin-like protein KIN-12A
- FAM10 family protein At4g22670
- Gibberellin-regulated protein 13
Sequence:
MNHLYKNPFRIYEISFHFCASLLLCFLLFSAQAVAGGGGGGHSWDGIVVTQANYQALQAIKHELIDFTGVLKSWNNSASSQVCSGWAGIKCLRGQVVAIQLPWKGLGGTISEKIGQLGSLRKLSLHNNVIAGSVPRSLGYLKSLRGVYLFNNRLSGSIPVSLGNCPLLQNLDLSSNQLTGAIPPSLTESTRLYRLNLSFNSLSGPLPVSVARSYTLTFLDLQHNNLSGSIPDFFVNGSHPLKTLNLDHNRFSGAVPVSLCKHSLLEEVSISHNQLSGSIPRECGGLPHLQSLDFSYNSINGTIPDSFSNLSSLVSLNLESNHLKGPIPDAIDRLHNLTELNLKRNKINGPIPETIGNISGIKKLDLSENNFTGPIPLSLVHLAKLSSFNVSYNTLSGPVPPVLSKKFNSSSFLGNIQLCGYSSSNPCPAPDHHHPLTLSPTSSQEPRKHHHRKLSVKDVILIAIGALLAILLLLCCILLCCLIKKRAALKQKDGKDKTSEKTVSAGVAGTASAGGEMGGKLVHFDGPFVFTADDLLCATAEIMGKSTYGTAYKATLEDGNEVAVKRLREKTTKGVKEFEGEVTALGKIRHQNLLALRAYYLGPKGEKLLVFDYMSKGSLSAFLHARGPETLIPWETRMKIAKGISRGLAHLHSNENMIHENLTASNILLDEQTNAHIADYGLSRLMTAAAATNVIATAGTLGYRAPEFSKIKNASAKTDVYSLGIIILELLTGKSPGEPTNGMDLPQWVASIVKEEWTNEVFDLELMRETQSVGDELLNTLKLALHCVDPSPAARPEANQVVEQLEEIRPETEVETETTPFGSGGEGGKDLGSNEE
Protein: Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) (Q32MK0)
Organism: Homo sapiens (Human)
Function: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Calmodulin-like protein 3
- Calmodulin-like protein 5
- Calmodulin-like protein 4
- Calmodulin-like protein 6
- Calmodulin-1
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin regulatory light chain 12B
- Myosin regulatory light polypeptide 9
- Myosin regulatory light chain 12A
- Myosin regulatory light chain 2, atrial isoform
Sequence:
MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP
Protein: Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Q8CCS6)
Organism: Mus musculus (Mouse)
Function: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86U42}. Nucleus {ECO:0000250|UniProtKB:Q86U42}. Nucleus speckle {ECO:0000250|UniProtKB:Q86U42}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. It is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle (By similarity). Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250|UniProtKB:Q28165, ECO:0000250|UniProtKB:Q86U42}.
Interaction partners:
- Poly
- ELAV-like protein 1
- Nuclear cap-binding protein subunit 1
- Serine/arginine-rich splicing factor 1
- Nuclear cap-binding protein subunit 2
- Embryonic polyadenylate-binding protein 2
- Zinc finger, C3H1-type containing
- Poly
- Poly
- Splicing factor U2AF 65 kDa subunit
Sequence:
MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAGDYGNGLESEELEPGELLPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEADPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRSRYRARTTNYNSSRSRFYSGFNSRPRGRIYRGRARATSWYSPY
Protein: AI-2 transport protein TqsA (Transport of quorum-sensing signal protein) (P0AFS5)
Organism: Escherichia coli (strain K12)
Function: Involved in the transport of the quorum-sensing signal autoinducer 2 (AI-2). Controls the transport of AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and motility and affects the global gene expression in biofilms.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Autoinducer-2 kinase
- Transcriptional regulator LsrR
- Uncharacterized serine protease YdgD
Sequence:
MAKPIITLNGLKIVIMLGMLVIILCGIRFAAEIIVPFILALFIAVILNPLVQHMVRWRVPRVLAVSILMTIIVMAMVLLLAYLGSALNELTRTLPQYRNSIMTPLQALEPLLQRVGIDVSVDQLAHYIDPNAAMTLLTNLLTQLSNAMSSIFLLLLTVLFMLLEVPQLPGKFQQMMARPVEGMAAIQRAIDSVSHYLVLKTAISIITGLVAWAMLAALDVRFAFVWGLLAFALNYIPNIGSVLAAIPPIAQVLVFNGFYEALLVLAGYLLINLVFGNILEPRIMGRGLGLSTLVVFLSLIFWGWLLGPVGMLLSVPLTIIVKIALEQTAGGQSIAVLLSDLNKE
Protein: TEP3 protein (Q9NFV6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLQGADMGAIPVLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVIDGEFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTSMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFGDDGISLTAFVTLALMENVDLYPEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICDICEHANCGDLCEKAEKRESKRPDDYTAIAGHSSGSRHTAIPLASVVMVLSMLLKTLSC
Protein: Glycine receptor beta subunit 2 (Glycine receptor, beta b) (Q6DC22)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Gephyrin
- Gephyrin
- Transporter
- G protein-coupled receptor, class C, group 5, member Bb
- Glycine receptor, alpha 3
- Glycine receptor subunit alphaZ1
- Glycine receptor subunit alpha-2
Sequence:
MKALKVIFMLLIICLWMEGGFTKEKSAKKGKKKGKQVYCPSQLSSEDLARVPANSTSNILNKLLITYDPRIRPNFKGIPVEDRVNIFINSFGSIQETTMDYRVNIFLRQRWNDPRLRLPQDFKSDSLTVDPKMFKCLWKPDLFFANEKSANFHDVTQENILLFIFRNGDVLISMRLSVTLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLQFMWQSGDPVQMDEIALPQFDIKQEDIEYGNCTKYYAGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGILSVLSLSSECTSLASELPKVSYVKAIDIWLIACLLFGFASLVEYAVVQVMLNSPKLLEAERAKIATKEKAEGKTPAKNTINGMGSTPIHVSTLQVTETRCKKVCTSKSDLRTNDFSIVGSLPRDFELSNFDCYGKPIEVGSAFSKSQAKNNKKPPPPKPVIPSAAKRIDLYARALFPFSFLFFNVIYWSVYL
Protein: Neurexophilin-2 (Q61199)
Organism: Mus musculus (Mouse)
Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MSLRPLPLLVVPGLLQLLFCDSEEVIHNTESVDWEDRTVPETLVGNLFHSRITSPLRLFVKQPPDPKPSYADNTKNFWDWLANITEIQEQLARTKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSLVPPSKVVEFEISPQSTLETKESKSFNCHIEYEKTDRAKKTALCNFDPSKICYQEQTQSHVSWLCSKPFKVICIHIIFYSVDYKLVQKVCPDYNYHSETPYLSFG