wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein eS21y (40S ribosomal protein S21-2) (Q3E902)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS12z
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein uS12z
- Small ribosomal subunit protein uS12y
Sequence:
MQNEEGQVTELYIPRKCSATNRLITSKDHASVQLNIGHLDANGLYTGQFTTFALCGFVRAQGDADSGVDRLWQKKKVEAKQN
Protein: Meiotic driver wtf4 (A0A218N034)
Organism: Schizosaccharomyces kambucha (Fission yeast)
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus; the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, leading to poisoning of all progeny that do not inherit the allele.
Subcellular location: [Isoform 1]: Spore membrane {ECO:0000255, ECO:0000269|PubMed:28631612, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:32032353, ECO:0000269|PubMed:33108274}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000255, ECO:0000269|PubMed:33108274}; Multi-pass membrane protein {ECO:0000255}. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. {ECO:0000269|PubMed:28631612, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:33108274}.; SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm {ECO:0000269|PubMed:28631612, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:33108274}. Cytoplasm {ECO:0000269|PubMed:28631612}. Spore membrane {ECO:0000269|PubMed:28631612, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:32032353, ECO:0000269|PubMed:33108274}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000255, ECO:0000269|PubMed:33108274}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000255, ECO:0000269|PubMed:33108274}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1. {ECO:0000269|PubMed:28631612, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:33108274}.
Interaction partners:
Sequence:
MKNKDYPLRSSMDELSTKNDNEIDLEKGPLPEYNSEDESTLPPYSEIWKYIKTVSEDSSTGPTETTNPNVERRQEFKDSHPNIYSLLRLLISVLAVIVVFFTAWVCVNPLEKSIFGKVAFFVTIGITCPILLITIFCFFETWTQAVAQCIKVTVIFLAQCVKVTAVGLYNSREKWVVIIWLLWVVICYTLFLRSKFGNLNLNKALICSTCSISAALLLFLLYVRLPFWTLKHMFSGLFQVLGVQSCVVIVTKGLTYLFDKHIDATGYEIEASSLFVIGNFLFFYEMECPGALKRMPKFIRNGIASFLEGIGNIGRAFRGANDNNDIPLGEMEVESEV
Protein: LYR motif-containing protein 4 homolog (Protein bcn92) (O46098)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:29491838}.
Interaction partners:
- Iron-sulfur cluster assembly enzyme IscU
- Cysteine desulfurase, mitochondrial
- Frataxin homolog, mitochondrial
- Cytochrome b
- Acyl carrier protein, mitochondrial
- GEO02460p1
- Adrenodoxin-like protein 2, mitochondrial
- Adrenodoxin-like protein 1, mitochondrial
- GH14121p
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
Sequence:
MSTRRQAITLYRNLLRESEKLPSYNFRMYAARKIRDTFRANRSTRDFAEIDRQMAEGQQNLELIRRQVIIGHLYSADKLVIENKKTLKPSDD
Protein: Alpha-2 macroglobulin-like protein (Alpha-2-macroglobulin-like precursor) (B8QSI4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MALNVSCCWKGLLLNFFLFVCVNGQAAEPSFMVTFPAVIESGSEAKLCASLLKPNESLVMNIYLVHGNQSTLLLQENAEQEFHRCFNFKAPLAEAESVQKIKVELQGESFKMTEERKVMFKSYDPLTFIQTDKPIYMPGQIVNFRVVTMDTNFAPVDQQYSIIVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAFIGERMSSHYFQVKKYVLPKFEVTVKKPKTVSVVEEELLIEVCAKYTYGQPVPGKSWVKVCRNPLPYIIFFPLCLEETLEITKTGCAIHNFGLSMILNSTLKDNLKDSLHVEAVVTEEGTEITMTKSESVHLTYEIGKITLIDLPKTYEPGSVIEGKIKLSDFKDAPIPNKEVYLLEGENWSSKLLLNLTTDSDGLASFSLNTSSLSKKDISLIANVYPDTRYYGYKTPYFSTDKKTVQLFRIATVYSPTLSELIIEDIEQPLKCGTEITATVKYYFVGETVEDFSTDIVYMVLSRGVIVHHGFEKVEVKSSSNGLASGTMSFKLSVGADVAPVVQILAYCVLPSENVIAANKRLDTEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLDADKIFNLLPVQSVSYYPYSVEDEQACLYVRPRRSVLTDNTYETLKSVGLKMATNLAVRVPDCLSYRGLTYHKNLVMYPDHRPVPVMFALGMAGVDGPVGNSPSVTIRTVFPETWIWELAEVGDSGSAEVPVTVPDTITTWETEAFCLSSTGLGLAPPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYSSCLCANGRKTFKWILTPSVLGVVNVTVSAEAEASQTVCDNEIVSVPERGRIDIVTRSLLVQAEGIEKTETNSWLLCPKGDSLSEKVDLTLPKDVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVTDPVITKGLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSRSASADDSASLDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAGDSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQIAQFYNIPTPTEAKTLSIDAKIEGDCEALGQNFIFDFTVKYDGPEEKTNMAIVDIKLLSGFTADTSALGTSSGTYVSLVERVDSKDDHVIVYLKEISKNVAMNYQIQMKQVLQVKNLKPAVVKVYDYYQTSDQSEIEYSFHCEALKNIN
Protein: Ferredoxin-3, chloroplastic (AtFd3) (Q9ZQG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Ferredoxin--NADP reductase, root isozyme 1, chloroplastic
- Ferredoxin--NADP reductase, root isozyme 2, chloroplastic
- Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic
- Photosystem I reaction center subunit IV B, chloroplastic
- Ferredoxin--nitrite reductase, chloroplastic
- Photosystem I reaction center subunit III, chloroplastic
- Nitrate reductase 1
- Protein NAR1
- Photosystem I reaction center subunit IV A, chloroplastic
Sequence:
MATVRISSTSMTKAVLRSQTTNKLITNKSYNLSVGSTKRVSRSFGLKCSANSGGATMSAVYKVKLLGPDGQEDEFEVQDDQYILDAAEEAGVDLPYSCRAGACSTCAGQIVSGNVDQSDGSFLEDSHLEKGYVLTCVAYPQSDCVIHTHKETELF
Protein: Cytotoxic granule-associated RNA binding protein 1 (Tia1 protein) (Q80ZW7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVRTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPNNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPPTYGQWGQWYGNAQQIGQYVPNGWQVPAYGVYGQPWSQQGFNQTQSSAPWMGPNYSVPPPQGQNGSMLPSQPAGYRVAGYETQ
Protein: CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) (Q9CWW7)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q9P0U4}. Nucleus {ECO:0000269|PubMed:30365547}. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes (By similarity). {ECO:0000250|UniProtKB:Q9P0U4}.
Interaction partners:
- Retinoblastoma-binding protein 5
- WD repeat-containing protein 82
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Protein dpy-30 homolog
- Histone-lysine N-methyltransferase SETD1B
- WD repeat-containing protein 5
- Histone-lysine N-methyltransferase SETD1A
- Histone-lysine N-methyltransferase PRDM9
- Host cell factor 1
- Biorientation of chromosomes in cell division protein 1-like 1
Sequence:
MEGDGSDLEPPDAGDDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKCRERDGSERAGSEPRDEGGGRKRPASDPELQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHHQQQQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSEALPRPRRPPPTQQQPQQSQKLGRIREDEGTVLSSVVKEPPEATATPEPLSDEDLALDPDLYQDFCAGAFDDHGLPWMSDAEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRAAQPGSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEENNENDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR
Protein: Protein ENHANCED DISEASE RESISTANCE 4 (Q9FHK4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a negative role in salicylic acid (SA)-mediated resistance to powdery mildew (e.g. Golovinomyces cichoracearum). May modulate plant immunity by regulating the relocation of EDR1 by interacting with CHC2 and modulating endocytosis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25747881}. Endosome {ECO:0000269|PubMed:25747881}. Note=Displays dynamic movement in cells with accumulation at the plasma membrane around pathogenic fungus penetration site. {ECO:0000269|PubMed:25747881}.
Interaction partners:
- Probable inactive receptor kinase RLK902
- Serine/threonine-protein kinase EDR1
- At4g01410 hydroxyproline-rich glycoprotein family)
- Clathrin heavy chain 2
- Protein ENHANCED DISEASE RESISTANCE 2
- AP-1 complex subunit mu-1
Sequence:
MASQTGQKIRLVRCPKCLKILQEDEDVPVYQCGGCSAILQAKRRNIAPSSTPSAGETERAQANEPQSVPETNNVSSSSGQDTVLPSSPGRSVDQEYEKGRNASMESTEKELDDLELSNGDGTNEIQEQECSLGDSEKNEREDNSRLESHMMNTVAEAAGSGSSSGSLSVDHVVAARASNPSGNSEISPDASPVEEKQSQLDILANKTPSAYDVVAARASNSSGNAEISPDASPVEEKQSQLDYPANKTSSAYDGSESSSDEREGQLLDDDEQWNALQKIRSGKFEMHRYPGYKEQGASSSSPFSENRRNGITTYNERHQNRSLQLEGPGGRLGRQGRRHVTEQLRPDMPFYPRESYTRGSPSHPSHDEFDRYPRAHSLQMPSYAGGMNHDFVDYMYHNNPRARGQGQGSRISGEMGRNHGGWYSGQLHNSYSSYSASPQRPMEQPEYHPRWRREIVSDVEDHQRNRHAGHHHELQTRRLRERQRVAKRHVRPTAGGAPFVSCYSCSENLQLPVDFLIFKRKHHLLRCGTCTTVLRFSLQSRNHLVPAVTHDINANRNSNSTSESPIDKAPSKPEKLRSSVQDEELPVARGSPLHRLMGYSTVSQVFKVSQRPPSI
Protein: Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein homolog) (Q3U128)
Organism: Mus musculus (Mouse)
Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-3a
Sequence:
MSRVRRLLLGYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFMTRSYRFYNNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHGVQVICHTEAVAEQLSRLVNRTCPGFLAPGGPWVQDVAYDLWQEESNHECTKAVNFAMHELQLIRVEKQYPHHSLDHLVEELFLGDIHTDATQRVFYRPSSYQPPLQNAKNHNHACIACRIIFRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFTIYARGRYSRGVLSSKVMGGTEFVFKVNHMKVTPMDAATASLLNVFSGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDTRGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEELLEDSQGHLYGRAAGRTAGSLLLPAFVSLWTLPHWRILR
Protein: Small ribosomal subunit protein mS75 (Protein GAMETE CELL DEFECTIVE 1, mitochondrial) (AtGCD1) (Q9LVA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for fertility (male and female gametophyte functions and development). Required for the integrity of female gametic mitochondria. Modulates male gametophyte functions, including pollen tube growth and style penetration. Involved in mitochondrial-driven cell-to-cell communication in embryo sacs during female gametes maturation (including embryogenesis initiation and endosperm development), especially for reciprocal signaling between central and egg cells which regulates reciprocal development.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:23085019, ECO:0000303|PubMed:36423343}.
Interaction partners:
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein uS9m
- Uncharacterized protein
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Cysteine--tRNA ligase, chloroplastic/mitochondrial
- AT3g18240
- ADP,ATP carrier protein 2, mitochondrial
- Inner centromere protein, ARK-binding region protein
- At1g64880
- Small ribosomal subunit protein mL104
Sequence:
MYNLSRIIYRFSSVSLNPSTRASGFLLENASSKILQSATNRAFSAKSGSDGVGGDDNGWNISTGGSFGGTGSADLDWDNKSMWSTGLTKEHFDGVSVGRQKNAANPSSDNTPSDSGDVMSKLGPKEVALVNEMNEYDDLLKEIEQDNRQGRAFVDGIKQRMMEISVLLKQVKEPGARGSYLKDSEKTEMYRLHKENPEVYTIERLAKDYRIMRQRVHAILFLKEDEEEEERKLGRPLDDSVDRLLDEYPEFFISHDREFHVASLNYKPDFKVMPEGWDGTIKDMDEVHYEISKKEDDMLYEEFVRRFEFNKMKWRGEVMCHKYSRRRSSEGWKITVEKLGAKGKRGAGGGWKFMSLPDGSSRPLNEMEKVYVKRETPLRRRSIISTEVMRYSPANQKRRSKRKQKRKERRIACLKAGKQT
Protein: Myelin basic protein (F8W3V8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Myelin membrane {ECO:0000256|ARBA:ARBA00004392}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004392}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004392}.
Interaction partners:
Sequence:
MATASTSGQNPFGLGRKKKAPGVLDQISRFFGGDKKRKGKGSFRGHLSSSPQRPHHSSTRRRGDVNPVVHFFRSFVSSPRPKSRWRELLGLGESRSRSPPKRWSTIF
Protein: Odorant receptor M36 (Olfactory receptor Olfr960) (Olfactory receptor family 10 subfamily D member 4B) (Q9EQ85)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTNNTMVTEFTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAALRHVFLKRCLSLEVNENI
Protein: Succinate dehydrogenase subunit 7, mitochondrial (Q6H611)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Succinate dehydrogenase subunit 5
- Succinate dehydrogenase subunit 4
- Succinate dehydrogenase subunit 6
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase subunit 3-1
- Succinate dehydrogenase subunit 3-2
- Succinate dehydrogenase subunit 8A
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase subunit 8B
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
Sequence:
MAQPAFLSALRSRLRSPQPQAPALPHLQPPRRGFHVELGAREKALLEEDTALKRFKSYKNSVKQVSKVGNILTGVVLFACAYEIVALANS
Protein: Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) (P60330)
Organism: Mus musculus (Mouse)
Function: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Securin
- Serine/threonine-protein kinase PLK1
- Meiotic recombination protein REC8 homolog
- Double-strand-break repair protein rad21 homolog
- Structural maintenance of chromosomes protein 3
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Structural maintenance of chromosomes protein 1B
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Cohesin subunit SA-1
- Cell division cycle protein 20 homolog
Sequence:
MRNFKGVNFATLLCSKEETQQLLPDLKEFLSRSRTDFPSSRTDAERRQICDTILRACTQQLTAKLDCPGHLRSILDLAELACDGYLLSTPQRPPLYLERILFILLRNGSTQGSPDTVLRLAQPLHACLVQNSGEAAPQDYEAVTRGSFSLFWKGAEALLERRAAFSTRLNALSFLVLLEDGSVPCEVPHFASPTACRLVAAYQLYDATGQGLDEADADFLYEVLSRHLIRVLVGEGGSSPGPLSPQRALCLLEITLEHCRRLCWNHHHRQAARAVERARNHLEKTSVAPSLQLCQMGVELLEAVEERPGAVAQLLRKAAAVLINSIEAPSPPLRALYDSCQFFLSGLERGIRRHCGLDAILSLFAFLGGYSSLVRHLREVSEASSKQQQCLLQMHFQGFHLFTGIVYDFAQGCQATELAQLVDGCRSAAVWMLEALEGLSGGELADYLSMTASYTSNLAYSFFSQKLYEEACVISEPVCQHLGSATSGACPEVPPEKLHRCFRLHVESLKKLGKQAQGCKMVTLWLAALKPYSLEHMVEPVTFWVRVKMDASRAGDKELQLQTLRDSLSCWDPETQSLLLREELRAYKSVRADTGQERFNIICDLLELSPEETAAGAWARATYLVELAQVLCYHNFTQQTNCSALDAVQEALQLLESVSPEAQEQDRLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPSNLEEFEVNDLNYEDKLQEDRFLYSSIAFNLAADAAQSKCLDQALTLWKEVLTKGRAPAVRCLQQTAASLQILAAVYQLVAKPLQALETLLLLQIVSKRLQDHAKAASSSCQLTQLLLNLGCPSYAQLYLEEAESSLRSLDQTSDACQLLSLTCALLGSQLCWACQKVTAGVSLLLSVLRDPALQKSSKAWYLLRVQALQVLAFYLSLSSNLLSSALREQLWDQGWQTPETALIDAHKLLRSIIILLMGSDVLSIQKAATESPFLDYGENLVQKWQVLTEVLTCSERLVGRLGRLGNVSEAKAFCLEALKLTTKLQIPRQCALFLVLKGELELARGDIDLCQSDLQQVLFLLESSTEFGVVTQHPDSVKKVHTQKGKHKAQGPCFPPLSEEEPFLKGPALELVDTVLNEPGPIQSSVNSSPVLKTKPPPNPGFLSHLPSCDCLLCASPALSAVCLRWVLVTAGVRLATGHKAQGLDLLQAVLTRCPAATKRFTQSLQASLNHRTTPSCVPSLFDEIMAQVYTHLALEFLNQTSEKSLGKVLASGLKFVATRIQSLEIWRAHLLLVQALAKLAHFSCCTSELFASSWGWHPPLVKSLPVLEPAKIRRQKCSGRGRRRIASVPPPLHNSSQKGLEEEGPPCTPKPPGRARQAGPRVPFTIFEEVHPTKSKLQVPLAPRVHRRAQTRLKVIFSDDSDLEDLVSADTQLVEEPKRRGTASRTRGQTRKGRSLKTDAVVAIESTPGHSSVSGRTRRARKVASRNCEEESPKAPLCVWASQGPEIMRSIPEEEPVDNHLEKSFEILRGSDGEDSASGEKAAAADTGLPVGECEVLRRDSSKAERPVLYSDTEANSDPSPWLPPFSVPAPIDLSTLDSISDSLSIAFRGVSHCPPSGLYAHLCRFLALCLGHRDPYATAFLVAESISITCRHQLLTHLHRQLSKAQKQQESPELAEHLQRLDLKERPGGVPLARIQRLFSFKALGSGCFPQAEKESFQERLALIPSGVTVCVLALATLQPGTLSNTLLLTRLEKDNPPITVKIPTAQNKLPLSAVLKEFDAIQKDQKENSSCTEKRVWWTGRLALDQRMEALITALEEQVLGCWRGLLLPCSADPSLAQEASKLQELLRECGWEYPDSTLLKVILSGARILTSQDVQALACGLCPAQPDRAQVLLSEAVGQVQSQEAPRSQHLVLVLDKDLQKLPWESTPILQAQPVTRLPSFRFLLSYTVTKEAGASSVLSQGVDPQNTFYVLNPHSNLSSTEERFRASFSSETGWKGVIGEVPSLDQVQAALTERDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGAPFLYYASQARQAPRLKYLIGAAPVAYGLPISLQTP
Protein: DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (Q6NXY9)
Organism: Mus musculus (Mouse)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:21898682}. Cytoplasm {ECO:0000269|PubMed:21898682}. Note=In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts. {ECO:0000269|PubMed:21898682}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerase III subunit RPC4
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase III subunit RPC10
Sequence:
MAGNKGRGRAAYTFNIEAVGFSRGEKLPDVVLKPPPLFPDTDYKPVPLKTGEDEDYMLALKQELRETVKRLPYFIEPPEEKQDDIERYSKRYMKVYKEEWVPDWRRLPREMMPRKKCKKGDPKSKPSKAAAKATSLINSADVLKTIEELEKRGEGERSDEENEEKEGSKEKDKDDEEDGEEDAEQEDYDEEEQEEENDYINSYFDNGDDFGVDSDDNMDEATY
Protein: Annexin D5 (AnnAt5) (Q9C9X3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alpha/beta-Hydrolases superfamily protein
- At2g43110
- NEFA-interacting nuclear protein
- BTB/POZ domain-containing protein At3g19850
Sequence:
MATMKIPMTVPSPRVDADQLFKAFKGRGCDTSVIINILAHRNATQRALIEQEYETKFSDDLRKRLHSELHGHLKKAVLLWMPEAVERDASILKRSLRGAVTDHKAIAEIICTRSGSQLRQIKQVYSNTFGVKLEEDIESEASGNHKRVLLAYLNTTRYEGPEIDNASVENDARTLKSAVARKHKSDDQTLIQIFTDRSRTHLVAVRSTYRSMYGKELGKAIRDETRGNFEHVLLTILQCAENSCFYFAKALRKSMKGLGTDDTALIRIVVTRAEVDMQFIITEYRKRYKKTLYNAVHSDTTSHYRTFLLSLLGPNV
Protein: Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) (Q6UXH1)
Organism: Homo sapiens (Human)
Function: Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16238698}.
Interaction partners:
- Stromal cell-derived factor 2-like protein 1
- Mesencephalic astrocyte-derived neurotrophic factor
- Protein disulfide-isomerase A4
- Hypoxia up-regulated protein 1
- DnaJ homolog subfamily B member 11
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Neuronal acetylcholine receptor subunit alpha-4
- Endoplasmic reticulum chaperone BiP
Sequence:
MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL
Protein: Caldesmon 1 (E9QA15)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSGPSRRMQNDSAENETAEGEEKRESRSGRYEVEETEVVIKSYQKNSYQDAEDKKKEEKEEEEQEKLKGGSLGENQVEKMVEEKTPEIQEEAVLMVLENGQVSAEESKIEGDGEQDMEEIARRKKMGEEERERAEAERLRLEVEGQEQERIKAEQDRKLAEERARVEAEQKAAAEERERREAEERERREAEERERREAEERAEQARIQEEQRRVAEAQKKAKAEEEEKARIEEQRQKQQLEEQRSEKREAKDKGEKGAEKADRKGVNEREAPDDRLQTAVPKTQEEEKGVKGQAQRQKPRDDKPAFRKEEIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSRSGGRASGDKEAEGAPQVEAGKRLEELRRRRGETENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSGVRSTHQAAVVSKIDSRLEQYTNAIEGTKASKPMKPAASDLPVPAEGVRNIKSMWEKGSVFSAPSASGTPNKETAGLKVGVSSRINEWLTKSPDGNKSPAPKPSDLRPGDVSGKRNLWEKQSVDKVTSPTKV
Protein: G-protein coupled receptor homolog US28 (HHRF3) (P69332)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling. May also function as a G protein sink to sequester G protein from the cell surface via internalization. Interacts with endogenous Gaq/11 subunits and thereby constitutively activates phospholipase C.
Subcellular location: Host cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
Protein: Prolyl 4-hydroxylase subunit alpha 2 (C9JX45)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRG