wanglab/gogpt-training-data huggingface dataset:
Protein: E3 SUMO-protein ligase PIAS2 (EC 2.3.2.27) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) (RING-type E3 ubiquitin transferase PIAS2) (Q8C5D8)
Organism: Mus musculus (Mouse)
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity).
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:12077349}. Nucleus, PML body {ECO:0000250|UniProtKB:O75928}. Nucleus {ECO:0000269|PubMed:12193603}. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349). {ECO:0000250|UniProtKB:O75928, ECO:0000269|PubMed:12077349}.
Interaction partners:
- Small ubiquitin-related modifier 1
- SUMO-conjugating enzyme UBC9
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 3
- Signal transducer and activator of transcription 3
- E3 SUMO-protein ligase NSE2
- Signal transducer and activator of transcription 1
- Signal transducer and activator of transcription
- Androgen receptor
- Signal transducer and activator of transcription 2
Sequence:
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLCDLSTIKSSVFSLDGSSSPVEPDLPVAGIHSLPSTSITPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSETGVITSSGRNIPDIISLD
Protein: Erlin (Endoplasmic reticulum lipid raft-associated protein 1) (A3QMC6)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22269071}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O75477}.
Interaction partners:
- ER membrane protein complex subunit 2
- Band 7 domain-containing protein
- Band 7 domain-containing protein
- E3 ubiquitin ligase rnf-5
Sequence:
MLTELALGLFALWIAIFSQALHKIEEGHVGVYYRGGALLKAVTNPGYHMHIPFLTTVKSVQVTLQTDEATNVPCGTSGGVLIYFDRIEVVNFLSQDSVYAIVKNYTVDYDRPLIFNKVHHEVNQFCSVHTLQEVYIDLFDKIDEEIKNALQEDLVKMAPGLYVQAVRVTKPKIPEAIRLNYEKMEAEKTKLLVAQETQKVVEKLAETERKKAVIEAEKAAQVALIHQKRLLSEKETEKLLNQMEAESNLASERSKADAEFYKAQKQADSNKILLTKEYLELQKIRAIASNNKIYYGDSIPQAFVMGTTQQTV
Protein: CD48 antigen (BCM1 surface antigen) (BLAST-1) (MRC OX-45 surface antigen) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (CD antigen CD48) (P10252)
Organism: Rattus norvegicus (Rat)
Function: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:3181129}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:3181129}. Membrane raft {ECO:0000250|UniProtKB:P09326}. Secreted {ECO:0000250|UniProtKB:P09326}.
Interaction partners:
- Natural killer cell receptor 2B4
- T-cell surface antigen CD2
- Proto-oncogene tyrosine-protein kinase LCK
- T-cell surface glycoprotein CD4
- Receptor-type tyrosine-protein phosphatase C
- CAMPATH-1 antigen
- Leukocyte surface antigen CD53
- SLAM family member 6
- SH2 domain-containing protein 1A
- Mast/stem cell growth factor receptor
Sequence:
MYFKKRRWFLILESLLLSLVTGFQDQSVPNVNAITGSNVTLTILKHPLASYQRLTWLHTTNQKILEYFPNGKKTVFESVFKDRVDLDKTNGALRIYNVSKEDRGDYYMRMLHETEDQWKITMEVYDLVSKPAIKIEKTKNLTDSCHLRLSCKVEDQGVDYTWYEDSGPFPQRNPGYVLEITITPHNKSTFYTCQVSNPVSSENDTLYFIPPCTLARSSGVHWIAAWLVVTLSIIPSILLA
Protein: Uncharacterized protein (Q582U0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cleavage and polyadenylation specificity factor 30 kDa subunit
- Cleavage and polyadenylation specificity factor subunit, putative
- Suppressor of forked domain-containing protein
- C3H1-type domain-containing protein
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor-like protein, putative
Sequence:
MSAIEQANFRLQAGSELVVVVPYSTERCSATLKVVSGAGGLEPRVDVLGAPVIVDVSYNLPPGITFTVFTWSNANIRIEGSKQLVQNCFRSTTHPFARSIVEYHCLIHNARLLADKQGLFGPMVLICGQNDTEKHAISRTLSSYAARTGWAPQFVDLDCGMGQLLSTPGTVAACVSECPMTLDEDTSTGPLSVAFFVGSTEPQVKGVSGEWNMFAPYVHYCRLLLSCVSERIARHKGGAGGSSGAIIVLPELRGSNGLLFVVDIIRQFNISHILCVGDDFLFCGLHERIPRLREHMASRVGGDIRLDKLSGSPHFPSPDTRTERLSSIMERYFFGGGAVDLQPSEINRRYASIEILLLKEANGQAVVSPVEQDALEGVVGCVGSLFESSAIHEKGALSLAPFALARVQGIDANGVSLLVSTHSAIPERLTMIVGAFRWVTS
Protein: Transcription termination/antitermination protein NusA (O83862)
Organism: Treponema pallidum (strain Nichols)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
Interaction partners:
- DNA-directed RNA polymerase subunit alpha
- Cytidylate kinase
- Transcription termination/antitermination protein NusG
- DNA-directed RNA polymerase subunit beta
- Small ribosomal subunit protein uS7
- DNA-directed RNA polymerase subunit beta'
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL24
Sequence:
MFGVSNDDIRKYAQEKGLDEDFAFKIVEQTLKAAYKTTFKTDENAVVTFGEERVCIYARKRVVEEVYDRVSEVDLSTALELDPTTSLDSEVLVELESEDFKRGSVQAAVQRITELSREIQKDALYAEYKSKEGEIIVGYYQRARNEHIYVDLGKVEGLMPKSHQLPQDDYRQNDRIKSLVREVRKHPKSSVVQLILSRTDSAFVKELLAVEVPEIYDGIVEVAKIVREPGYRTKIAVTSRRDDVDPVGACVGPRGIRIRMVIKELNDEKIDVLEYSPDPVIFIKNALSPAEVLNVVVLDEEKRSALAIVAESQLSIAIGKQGLNVRLANRLVDWNIDVKTESQFEEMDVYTDTRRAAENLFDNDYQEESEFSSYVGFTPELIKILQDNGIQDVQTLVDLGEEGLRALEGMDEAHVQELLAAIEENFEVVEEGEEASVTSSPGTGGDEDQALQCPECGVRITTDMSECPHCGIGLSFEFEYEENEE
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4ISN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g49990
- Serine/threonine-protein kinase MPS1
- Protein AE7-like 2
- Protein AE7-like 1
- FHA domain-containing protein DDL
- E3 ubiquitin-protein ligase RHF1A
- Bystin
- Serine/threonine-protein kinase RIO2
Sequence:
MPELRSNARRDRDKKNPKQNPIALKQSPVRRNPRRQLKKKVVVKEAIVAAEKTTPLVKEEEEQIRVSSEDKKMDENDSGGQAAPVPDDEGNAPPLPEKVQVGNSPMYKLDRKLGKGGFGQVYVGRKMGTSTSNARFGPGALEVALKFEHRTSKGCNYGPPYEWQVYNALGGSHGVPRVHFKGRQGDFYVMVMDILGPSLWDVWNSTTQAMSTEMVACIAIEAISILEKMHSRGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLASKWRDTATGLHVEYDQRPDVFRGTVRYASVHAHLGRTCSRRDDLESLAYTLVFLLRGRLPWQGYQVGDTKNKGFLVCKKKMATSPETLCCFCPQPFRQFVEYVVNLKFDEEPDYAKYVSLFDGIVGPNPDIRPINTEGAQKLIHQVGQKRGRLTMDEEDEQPTKKIRLGMPATQWISIYSAHRPMKQRYHYNVTDTRLAQHIEKGNEDGLFISSVASCTDLWALIMDAGSGFTDQVYQLSPSFLHKEWIMEQWEKNYYITAVAGANSGNSFVVMSKGTQYLQQSYKVSDSFPFKWINKKWREGFYVTSMATAGSKWGIVMSRGASFSDQVIELDFLYPSEGIHRRWENGYRITSVAATWDQAAFVLSVPRRKLTDETQETLRTSAFPSNHVKEKWGKNLYIASICYGRTVS
Protein: Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (EC 6.2.1.-) (Q4LDG0)
Organism: Mus musculus (Mouse)
Function: Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes. Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y2P5}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000250|UniProtKB:Q9ES38}. Cell membrane {ECO:0000269|PubMed:16618416}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Bile acid-CoA:amino acid N-acyltransferase
- Sterol 26-hydroxylase, mitochondrial
- Acyl-coenzyme A amino acid N-acyltransferase 2
- Acyl-coenzyme A amino acid N-acyltransferase 1
- Sterol carrier protein 2
- Alpha-methylacyl-CoA racemase
- Acyl-coenzyme A thioesterase 8
- Bile salt export pump
- Peroxisomal acyl-coenzyme A oxidase 2
- Solute carrier organic anion transporter family member 1B2
Sequence:
MGIWKKLTLLLLLLLLVGLGQPPWPAAMALALRWFLGDPTCLVLLGLALLGRPWISSWMPHWLSLVGAALTLFLLPLQPPPGLRWLHKDVAFTFKMLFYGLKFRRRLNKHPPETFVDALERQALAWPDRVALVCTGSEGSSITNSQLDARSCQAAWVLKAKLKDAVIQNTRDAAAILVLPSKTISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVRSSGASVLIVDPDLQENLEEVLPKLLAENIHCFYLGHSSPTPGVEALGASLDAAPSDPVPASLRATIKWKSPAIFIFTSGTTGLPKPAILSHERVIQVSNVLSFCGCRADDVVYDVLPLYHTIGLVLGFLGCLQVGATCVLAPKFSASRFWAECRQHGVTVILYVGEILRYLCNVPEQPEDKIHTVRLAMGNGLRANVWKNFQQRFGPIRIWEFYGSTEGNVGLMNYVGHCGAVGRTSCILRMLTPFELVQFDIETAEPLRDKQGFCIPVEPGKPGLLLTKVRKNQPFLGYRGSQAESNRKLVANVRRVGDLYFNTGDVLTLDQEGFFYFQDRLGDTFRWKGENVSTGEVECVLSSLDFLEEVNVYGVPVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYATPHFIRIQDSLEITNTYKLVKSRLVREGFDVGIIADPLYILDNKAQTFRSLMPDVYQAVCEGTWNL
Protein: 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Q8VDM4)
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome regulatory subunit 8
- Proteasome subunit alpha type-2
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 6
Sequence:
MEEGGRDKTPVQSQQPSATTPSGADEKSSGKERRDAGEKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKCFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKAQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL
Protein: Pyruvate kinase (EC 2.7.1.40) (D3YT37)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVAT
Protein: N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18) (Q8K1Z6)
Organism: Mus musculus (Mouse)
Function: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (By similarity). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists (By similarity). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity). May contribute to regulation of the immune system (By similarity). Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:23104136}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q14330}.
Interaction partners:
- Glucose-dependent insulinotropic receptor
- Cannabinoid receptor 2
- Cannabinoid receptor 1
- Transient receptor potential cation channel subfamily V member 1
- Fatty-acid amide hydrolase 1
- G-protein coupled receptor 55
- G-protein coupled receptor 3
Sequence:
MATLSNHNQLDLSNGSHPEEYKIAALVFYSCIFLIGLFVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGEYFCHILGALVVFYPSLALWLLAFISADRYMAIVQPKYAKELKNTGKAVLACGGVWVMTLTTTVPLLLLYEDPDKASSPATCLKISDITHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIMTLLLQVLVCFVPFHICFAVLMLQGQENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML
Protein: Zinc finger and BTB domain containing 14 (F1LMU5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPIGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS
Protein: Spectrin repeat containing nuclear envelope protein 1 (Q5JV20)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus outer membrane {ECO:0000256|ARBA:ARBA00046312}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00046312}.
Interaction partners:
Sequence:
MVVAEDLSALRMAEDSCVDADLPDCNCDVTRVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Protein: Universal stress protein Rv2028c (USP Rv2028c) (P9WFD9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- ATP-dependent 6-phosphofructokinase isozyme 2
- Uncharacterized protein Rv2030c
- Putative NAD
- Alpha-crystallin
- DNA-binding transcriptional activator DevR/DosR
- Probable cation-transporting ATPase F
- Putative zinc metalloprotease Rip3
- Oxygen sensor histidine kinase response regulator DevS/DosS
- Universal stress protein Rv2624c
- Probable membrane protein Rv1733c
Sequence:
MNQSHKPPSIVVGIDGSKPAVQAALWAVDEAASRDIPLRLLYAIEPDDPGYAAHGAAARKLAAAENAVRYAFTAVEAADRPVKVEVEITQERPVTSLIRASAAAALVCVGAIGVHHFRPERVGSTAAALALSAQCPVAIVRPHRVPIGRDAAWIVVEADGSSDIGVLLGAVMAEARLRDSPVRVVTCRQSGVGDTGDDVRASLDRWLARWQPRYPDVRVQSAAVHGELLDYLAGLGRSVHMVVLSASDQEHVEQLVGAPGNAVLQEAGCTLLVVGQQYL
Protein: Son of sevenless homolog 2 (SOS-2) (mSOS-2) (Q02384)
Organism: Mus musculus (Mouse)
Function: Promotes the exchange of Ras-bound GDP by GTP.
Interaction partners:
- SHC-transforming protein 1
- Growth factor receptor-bound protein 2
- Tyrosine-protein phosphatase non-receptor type 11
- Epidermal growth factor receptor
- GTPase KRas
- GTPase HRas
- GTPase NRas
- GRB2-associated-binding protein 1
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 2
Sequence:
MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDKECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYRHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADKLALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHYYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKTFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDALNSKGAVKSDDDPPAIPPRQPPPPKVKPRVPVLMGTFDGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTPPTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPRQNSSPLLPKLPPKTYKRELSHPPLYRLPLLENAETPQ
Protein: Uncharacterized protein T1P2.9 (Q9C8S1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Helicase and polymerase-containing protein TEBICHI
- Vacuolar protein sorting-associated protein 29
Sequence:
MVPSNNRCKWSSIFLFLLSVSVAVLVAVADDKSPAVEDGLVINGDFETSPSSGFPDDGVTDGPSDIPSWKSNGTVELINSGQKQGGMILIVPQGRHAVRLGNDAEISQDLTVEKGFVYSVTFSAARTCAQLESINVSVASVNADADDMLASRNVDLQTLYSVQGWDPYAWAFEAEDDHVRLVFKNPGMEDDPTCGPIIDDIAIKKLFTPDKPKDNAVINGDFEDGPWMFRNTSLGVLLPTNLDEEISSLPGWTVESNRAVRFVDSDHFSVPKGKRAVELLSGKEGIISQMVETKADKPYILSFSLGHAGDKCKEPLAIMAFAGDQAQNFHYMAQANSSFEKAGLNFTAKADRTRVAFYSVYYNTRTDDMSSLCGPVIDDVRVWFSGSKRIGAGFGFWVFVLLVVGLV
Protein: Calcium-transporting ATPase 2 (EC 7.2.2.10) (Q9HDW7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15470240}; Multi-pass membrane protein {ECO:0000269|PubMed:15470240}.
Interaction partners:
- Vacuolar calcium ion transporter
- Calcium-transporting ATPase 1
- NADPH--cytochrome P450 reductase
- Set1 complex component spp1
Sequence:
MPTYNDDDDSSRPPSVHSERNQKPSSSQFLGVPSSNYNQRENSSRSGSSTISREPSSSGTMYPMASRDSMKESYDKNKGTPPDYTSYVSHSDAEPEQASSKSSTSIEDLLHTEYDDAPFAFSIPLLQRLQDPKNTSLLHAIHGLKGLCKGLKVDPSTGISTHEPHYADKLQMSDILNDDSNPKLVVHLDRIRSQDNNPEAKVSHDSDRVKYYGKNVLPEHDSKGLIRLMLEAFKDKVLILLSIAAVVSLALGLYQTFGQPPTLDPITGKPEPRVEWVEGVAIMAAIVIVVTVGGVNDWQKELQFKKLNAKVSNFDVQVLRDGAVHSTSVFDLVVGDVLFVEAGDVVPVDGVLIESNNLVLDESAMTGETDNIKKVDANTAIERTSPDVEYRKNADPYLISGTTILEGNGKLLVTAVGVNSFNGRTTMAMRTEGQATPLQLRLSRVADAIAKLGGAASALLFIVLLIEFLVRLKSNDSSSKNKGQEFLQILIVSVTLLVVAVPEGLPLAVTLALAFATNRMQKDNNLVRHLQACETMGTATNICSDKTGTLTQNRMTVVAGGFGTDVLFFDHNDETPTNVDQGSDSSKFEDAGASAFAFKRLSPELRDLTLYSIAVNSTCRQLFEDNSDTPRFIGSKTETALLDMSVKELGLTNVDSMRSSVDIKQFFSFSSDRKASGAIFEYKDKYYFVVKGMPERVLQQSTSVITNGSLDEVEDMHSHADYFKEMITGYAKRSLRTLGLCYRVFDSWPPKDIPTNDEDSSNPLKWEDAFTDMTFLGFFGIMDPIRPDVPLAVKVCQGAGVTVRMVTGDNIVTAKAIASQCGIYTEDGISMEGPEFRSLSDEKRLEILPKLDVLARSSPLDKQLLIEGLQKLGNVVAVTGDGTNDAPALKKANVGFSMGKSGTEVAKEASDIILMDDNFSSIVKAIAWGRTVNDAVKKFLQFQITVNITAVFLTIISAVASTDQSSVLTAVQLLWVNLIMDTLAALALATDPPTPEVLKRKPEKPGASLFTFDMWKMIICQSMYQLAVTLVLHFAGNSIFHYPSNTADMNTIVFNTFVWLQLFNEINNRRLDNKLNIFERINHNFLFIAIFVIVAGIQVIIVFFGGAAFSVKRIDGKGWAISIVFGVISIPLGALIRCVPNNFLRKVLPVKTIDTVFSWILNPRFRSKRRSTDHDVESLSLIPYEPTSPNEVIDSIRHSLGFVQRIRGGRIRHLLNNSKFDKQMEALPERLRPRVKQRFMKIRSPSVSSATSVALMIPISTLVSEASGRLGGHDIWISHNRQALDKKSSNVH
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (Q5S255)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPVPRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADERPSFKILLSNILDVMDEES