wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 423 (Early B-cell factor-associated zinc finger protein) (Olf1/EBF-associated zinc finger protein) (Smad- and Olf-interacting zinc finger protein) (Q80TS5)
Organism: Mus musculus (Mouse)
Function: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor COE1
- Transcription factor COE2
- Mothers against decapentaplegic homolog 4
Sequence:
MSRRKQAKPRSVKVEEGEASDFSLAWDSSVAAAGGLEGEPECDRKTSRALEDRNSVTSQEERNEDDEDVEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQSWPKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETFSTEVELQCHITTHSKKYNCRFCSKAFHAVILLEKHLREKHCVFDAAAENGTANGVPPTSTKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLVRLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECNVKFESAEDLESHMQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQEDKIYDCSQCPQKFFFQTELQNHTMSQHAQ
Protein: ATP synthase subunit alpha, chloroplastic (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) (P0C2Z6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01346}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01346}.
Interaction partners:
- ATP synthase subunit d
- Os02g0750100 protein
- ATP synthase subunit b, chloroplastic
- ATP synthase epsilon chain, chloroplastic
- F-ATPase gamma subunit
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit c, chloroplastic
- ATP synthase subunit beta
- Os06g0646500 protein
- ATP synthase F1, delta subunit family protein, expressed
Sequence:
MATLRVDEIHKILRERIEQYNRKVGIENIGRVVQVGDGIARIIGLGEIMSGELVEFAEGTRGIALNLESKNVGIVLMGDGLMIQEGSFVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEIVASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQDVICVYVAIGQRASSVAQVVTTFHEEGAMEYTIVVAEMADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNSLLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKSKLELAQFAELQAFAQFASALDKTSQNQLARGRRLRELLKQSQANPLPVEEQIATIYIGTRGYLDSLEIGQVKKFLDELRKHLKDTKPQFQEIISSSKTFTEEAEILLKEAIQEQLERFSLQEQT
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (A1ZA97)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Antennal-specific protein OS-C
- Epoxide hydrolase
- General odorant-binding protein 83a
- General odorant-binding protein 19a
- Pheromone-binding protein-related protein 6
- General odorant-binding protein 69a
- Juvenile hormone acid O-methyltransferase
- General odorant-binding protein lush
- Putative odorant-binding protein A5
- Epoxide hydrolase
Sequence:
MLFAGFGVLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSITLTAFPIWKKLFA
Protein: ANK_REP_REGION domain-containing protein (Q9BPN3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSHTLIEALDDERETSVIQKILEEHPEEASQPNEEKKVAIHYAAASGDLKTLKLVFLADRSLLDVKDATGQTPLLCALMAGKIENADFLANTGADAECHDEQGRNALHWAVVCGQLDSLNWAINKNVEVNAKDQYQRCTPLHYATCSEDIAPEVSQAILITLLKHGADPNAIDADDRTPIHWCSSNGNLEAIKALYNSGGDLLCRDKEHLTILHCAASHGYHEVIEFALKHVNKPFIDEIDRAGHTALFYAISFGHYESALKLLQNNANPNHQDQRLATAAHSAASKGQMRMLKLLKQFNASFDIQNYRGDLPFHEAVQAGSKDVVEWLLAVDESVLDIPNHNGRTAIHLAASVGNLEMVILLCTKKCFVDPLCSREKEIFTPLDLATKQNHVVVVEYLTKLCRAKSSKEFSPEYIENWKTNFEAMVAEARRKRNELKAEQKKQRRPSTSDGIVETERKKEIADVGVNTSQRSIKSADSNAPKRKYSKSTSVTNLTEIPSIPKKELEALKESIENGQKFVDDDAEDHLDILDVDDEFENLPPISDLSESSTSTDNDSEEDKSDDEDVERKVTVQETKATVPLAAAKKTRKEVRIESGSNKKKKSASKSRGNVVMRVRREPEVGSDTGDVDIYDDGDGRPSDDEEEKKPNDKETASTPTNRRYIHERAIFQELTHLKRMQIQYGKVQEKVLVRSLISNFCKMHNLDVRNFKFTTFYAWERFLYDALSEQLKIIYLEERERLSETNSEMKPSGSMKLNKFDSKIRNSVPINDKFHDMQRIYTHAAITQKSTGKPRGKSAKPIESSRKRITRPWY
Protein: E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8) (Q5T0T0)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:32934085}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30759391, ECO:0000269|PubMed:35503863}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:35503863}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV
Protein: Catharanthine synthase (EC 5.5.1.37) (Hydrolase 1) (CrHL1) (A0A2P1GIW2)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to catharanthine.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:29724909}. Nucleus {ECO:0000269|PubMed:29724909}.
Interaction partners:
Sequence:
MNSSTDPTSDETIWDLSPYIKIFKDGRVERLHNSPYVPPSLNDPETGVSWKDVPISSQVSARVYIPKISDHEKLPIFVYVHGAGFCLESAFRSFFHTFVKHFVAETKVIGVSIEYRLAPEHLLPAAYEDCWEALQWVASHVGLDNSGLKTAIDKDPWIINYGDFDRLYLAGDSPGANIVHNTLIRAGKEKLKGGVKILGAILYYPYFIIPTSTKLSDDFEYNYTCYWKLAYPNAPGGMNNPMINPIAENAPDLAGYGCSRLLVTLVSMISTTPDETKDINAVYIEALEKSGWKGELEVADFDADYFELFTLETEMGKNMFRRLASFIKHE
Protein: Protocadherin alpha-C1 (PCDH-alpha-C1) (Q9H158)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MVGCGVAVLCLWVSCGAAAGQLEYSVPEETERGVAVGNLSADLRLPAAAMSSRNFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELHKIRIHVLDTNDNSPLFPAGDVQLHIPEFLTPGARFTLPNAQDDDEGSNGILSYSLSPSQHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFERSVYRTKVPETAPNGTVLFRVQALDPDEGSNGEVQYSLSNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLEAYIEARDEGVFGLASTAKLLVEVTDVNDHAPELDFLTLSNPVPEDAAPGTVIALFSVKDEDLDSNGRVICGMSSAGPFQLTASFDNYYSLLIDGPLDREQISEYQVLITASDSGSPPLSTRRTITVSVADVNDNTPNFPQPQQELFVAENNGPGASLGRVFAQDPDLGKNGLVSYELLDVISEGPSASSLLAVESSSGAITAKTSFDFEQLRGFHFQVEGRDGGIPPRSATVTINLFVVDRNDNYPVILFPLPRNGSVPVEIVPRSARTGHLVTKVVAEDADSGSNAWLSYHISRASDSSLFRISANIGELRTARLVLPTDAVKQRVVVVVRDHGDPPLSSSVTLGVLLSNSVPQLLPDFEDVWEPGGQLSAQNLYLVIALACISFLFLGCLLFFVCTKLHQSPGCCAQSCCRSTEDLRYGSKMVSNPCMTSATIDVTTVERLSQTYLYRASLGLGSDNNSLLLRGEYNAADLRNLATGVGLNLPISCIQIRNRKGDHANVNAMPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Uncharacterized protein YphB (P76584)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC
- Sulfoquinovosidase
- ABC transporter periplasmic-binding protein YphF
Sequence:
MTIYTLSHGSLKLDVSDQGGVIEGFWRDTTPLLRPGKKSGVATDASCFPLVPFANRVSGNRFVWQGREYQLQPNVEWDAHYLHGDGWLGEWQCVSHSDDSLCLVYEHRSGVYHYRVSQAFHLTADTLTVTLSVTNQGAETLPFGTGWHPYFPLSPQTRIQAQASGYWLEREQWLAGEFCEQLPQELDFNQPAPLPRQWVNNGFAGWNGQARIEQPQEGYAIIMETTPPAPCYFIFVSDPAFDKGYAFDFFCLEPMSHAPDDHHRPEGGDLIALAPGESTTSEMSLRVEWL
Protein: CTD nuclear envelope phosphatase 1 (I3L4B2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDA
Protein: Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) (Vasa-like protein) (xVLG1) (Q91372)
Organism: Xenopus laevis (African clawed frog)
Function: Probable ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8150200}. Nucleus {ECO:0000269|PubMed:8150200}. Note=Localizes to the cytoplasm of somatic cells, primordial germ cells (PGCs) and most adult germline cells, except spermatogonia where it is located in the nucleus (PubMed:8150200). Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (By similarity). {ECO:0000250|UniProtKB:Q61496, ECO:0000269|PubMed:8150200}.
Interaction partners:
Sequence:
MEENWDTEIETEKPTYVPNFSTLETENTDNYSAYSNNDINNQNYDSERSFGNRGGYRSERSRPSNFNRGSRTERGRGRGFGTNRNDNYSSERDVFGDDERDQRRGFPGRGGYNGNEDGQKPNAFRGRGGFRNENEQRRGFGERGGFRSENGQRNFDNRGDFGNSGEEEDRPRSYGRGGFNNSDTGGRGRRGGRGGGSQYGGYKGRNEEVGVESGKSQEEGNEKDEKPKKVTYIPPPPPDGEDNIFRQYQSGINFDKYDEILVDVTGKDVPPAILTFEEANLCETLRRNVARAGYVKLTPVQKHSIPIIMAGRDLMACAQTGSGKTAAFLLPILSYMMNEGITASQYLQLQEPEAIIIAPTRELINQIYLDARKFSYGTCVRPVVVYGGIQPVHAMRDVEKGCNILCATPGRLLDIVSKEKIGLSKLRYLVLDEADRMLDMGFAPEIEKLMTKPGMPTKEKRQTLMFSATYPEEIRRLASNYLKSEHLFVVVGLVGGACSDVAQTVLEMRENGKMEKLLEILKSSEKERTMIFVNTKKKADFIAGYLCQEKFSSTSIHGDREQYQRESALWDFRTGKCTVIVCTAVAARGLDIENVQHVINYDVPKEVDEYVHRIGRTGRCGNTGKATSFFNVQDDHVIARPLVKILTDAHQEVPAWLEEIAFGGHGALNSFYAADSMGEQAGGNAVTTPSFAQEEEASWD
Protein: Dynein regulatory complex subunit 4 (Growth arrest-specific protein 8) (A0A384MR00)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT
Protein: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (Q9BL79)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion {ECO:0000256|RuleBase:RU365024}.
Interaction partners:
- Phosphatidate cytidylyltransferase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Cardiolipin synthase
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- Tubulin-specific chaperone D
- Phosphoserine phosphatase
- Cytochrome-b5 reductase
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase
- Ribonuclease H2 subunit B wHTH domain-containing protein
Sequence:
MEIPDPELPGIPIDPQDLEILDTPTRFYEKLLELTASTERRLALCSLYLGEGDLEKNLIAAIRERSEKSEIEVTILLDFLRGTRTNSSGESSVTVLKPISEKSKIYLFHTPELSGLVKRVLPQRADEIIGLQHMKLYIFDDNVLISGANLSDSYFTNRTDRYFLFRNCKPLADFFHEIINVVADSSFIVENEQLVPSPKCDVHPYLGSAHLYREMLKTRVNRVIEKYKESRKTSSNCMSADTWIYPVLQMGLLGIHQEFEFLQKLFSLKNPELKMTMASGYFNFIRDYEESILKEGDYHLDILTASPFANGFFESNGFSKYIPPLYSNISDQFLRKREINGRLNVKMFEYRREEWTFHAKGLWAEHNNQLMTLIGSSNYGYRSVHRDLEAQVMVVTRNPTLIDRLKDEKNLLFEYSSILDMAALQQPEHHIPPLVRVISRLIRSFL
Protein: Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) (Q80Z29)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Subcellular location: Nucleus {ECO:0000269|PubMed:12782293}. Cytoplasm {ECO:0000269|PubMed:12782293}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
Interaction partners:
- NAD-dependent protein deacetylase sirtuin-1
- Nicotinamide-nucleotide adenylyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- NAD-dependent protein deacetylase
- Nicotinamide riboside kinase 1
- Sirtuin 6 6
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- NAD-dependent protein deacetylase sirtuin-2
Sequence:
MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVSENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGTFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNMEQDVAPH
Protein: Trip11 protein (Q811I5)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}.
Interaction partners:
Sequence:
RTRGGELNQLLNAVKSMQEKTVTFQQERDQVMLALKQKQMETSTLQNEVQRLQDKESRLNQELQRLRDHLLESEDSHTREALAAEDREAKLRKKVSVLEEKLVSSSNAMENASHQASVQVESLQEQLNMVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQNHLLAEWKKKAESLEGKVLSLQERLDEANAALDSASRLTEQLDLKEEQIEELKKQNELHQEMLDDAQKKLMSLVNSTEGKVDKVLMRNLFIGHFHTPKHQRHEVLRLMGSILGVKREEMEQLFAEDQGGVTRWMAGWLGGGSKSVPNTPLRPNQQSVFNSSFSELFVKFLETESHPSVPPPKLSVHGLKPLDSPGRRKADTGIPESFRDTAESRAGRRTDVNPFLAPRSAAVPLINPAGHGPGGPGHLLLKPISDVLPTFTPLPVSPDNSAGVVLKDLLKQ
Protein: RhoGAP1A (Q6W435)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
XEXNXXFFKIDELYDLHTGFLSDLKTIXSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSXIVLNLQTEQSLTXEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADSAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGGFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLK
Protein: Stanniocalcin (STC) (Corpuscles of Stannius protein) (CS) (Hypocalcin) (Teleocalcin) (P43649)
Organism: Oncorhynchus nerka (Sockeye salmon) (Salmo nerka)
Function: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.
Subcellular location: Secreted.
Interaction partners:
Sequence:
FSPNSPSDVARCLNGALDVGCGTFACLENSTCDTDGMHDI
Protein: Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) (P41229)
Organism: Homo sapiens (Human)
Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}.
Interaction partners:
- Histone-lysine N-methyltransferase EHMT2
- Histone deacetylase 1
- Histone H3.2
- Lysine-specific demethylase 6A
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- Histone-lysine N-methyltransferase SETD2
- MYND-type zinc finger-containing chromatin reader ZMYND8
Sequence:
MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL
Protein: Secretion related GTPase srgA-Aspergillus niger (EC 3.1.5.-, EC 3.1.5.1) (A2R2A0)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}.
Interaction partners:
Sequence:
MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFQNIRTWFSNVEQHASEGVHKILIGNKCDWEEKRAVSTEQGQQLANELGIPFLEVSAKNNINIEKAFYDLASDIKKGMDTSKSEQVGSQGVSIDQQGSGLNGSAGGKCC
Protein: Dawdle, isoform A (Dawdle, isoform B) (Dawdle, isoform C) (GH14433p) (Q9VQG9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- receptor protein serine/threonine kinase
- Follistatin, isoform A
- Serine/threonine-protein kinase receptor
Sequence:
MAKYFIALVLLVCLALENRNVYNRLHARSHPSSRGDILRPHPKHQPHPHVQHTSQQLQQQHHIRQQRSRQLKHLEPDPTSEEDDVPITKREYYARLRRHVIHKRQHLLQQELSYNHPGSHSEQLKVPRLWQHLMEQEEKAHRHVSPPVELPIMYGDAPEESSLSSDDHFDDLSPLDFVRNELMAEDQQNQEKDLDLDLDLDQQPETPIEPELPLGERNITISVKSSAGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVSAVELPKPIFDGMTLSHPDDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKSNPSMCFTFKIDDADAEGFDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQSVNVQDEWMKIDIEWPIKHWISGHELSHLIQITCGGCDVSDMEEIISVDKDYRPFIVIDMQNRRRKSRQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGCR
Protein: Protein RDM1 (Protein RNA-directed DNA methylation 1) (Q9LUJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:20410883}. Note=Peri-nucleolar.
Interaction partners:
- Protein DEFECTIVE IN MERISTEM SILENCING 3
- Protein CHROMATIN REMODELING 35
- Protein argonaute 4
- DNA-directed RNA polymerase V subunit 1
- DNA
- DNA-directed RNA polymerases IV and V subunit 4
- RNA-directed DNA methylation 4
- DNA-directed RNA polymerases IV and V subunit 2
- Histone-lysine N-methyltransferase family member SUVH9
- Protein RNA-directed DNA methylation 3
Sequence:
MQSSMTMELRPSGDSGSSDVDAEISDGFSPLDTSHRDVADEGSLLRRAEMYQDYMKQVPIPTNRGSLIPFTSWVGLSISMKQLYGQPLHYLTNVLLQRWDQSRFGTDSEEQRLDSIIHPTKAEATIWLVEEIHRLTPSHLHMALLWRSDPMYHSFIDPIFPEK