wanglab/gogpt-training-data huggingface dataset:
Protein: Filament-interacting protein (Q556T3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MEKSFAQQMLEQLSENVSQLILTVLELKDKNANLPVVEVTAIANAASSISDIAIKLADAEYSNYPSIYNEIINTTTNMSTIKKTTIDCIANFQTTTNKQLSWSNLIQSCKNIANETYKILKVIYDADIKRLKHLIETCKNQFKNNENSFGMIDREEFNGFGELVNQTISNLIEYSSCLEVKAKENQLSSPLQNQFIDDDDDDIIKLSQQLVEDANRLIDIVNDIFSDLDDPSQKQKFINHQNSLLNQLNHTFNLIQTNSPTLSLPEFTNVNNYIQSPIPSQYSTSNIKTIYNDNNNSNNNNNNNSIEINNEINNNNNIDKNENNNLLNDLIRGISKSCIEELRAACRGDPMATETISNSIQQLIPILNDTLNQHIKNNNNINKNEKEILEKSINKLKNDLIQKYIQSATLVTRSSGNQNVKNDEINKMIEGLESIQDCLNSIDGIVSTKEDQFLNAIKAKEDVLTILSDHSIANNTQAIVGTLKHLAKNQHQIEALITSTSTTPDDDNNNNNNSSINPEINEAVSKLSELLPLQIQAAKLYLKDSTNLENRKQFTDISNSMKLPLSKIQSLMEPSTISDSNELLSKQENSSNQVLLNNINNNSNNNNNNNIEENSKLIDKLLKDLENDNANLVGLIESELVLSNDTLLKEFVKKTIDQLLKEVQNRRDIGMNKFSKSPFDKDVKQEFLKSNQLISDLSKSLIDCLKSFEVVPLLKLQLLNCHPQSVTPNSPKLQSTQKDINNRINSIIYNYKDQMLDQPLIENQIKQLESYQNQLNQELSKDLNGSKDNLSYILDNIINNISNLSNLPSSSTNDGDGGGRQVIIPIENLNDEIIDGINEEINKEIIKENKENEIKRDNERLEELKQLENLSNDQKLLKLFNDLIQYLKNNEANKSVVTLKQLIGEQDKLIQLGNEIKQNSNSQDFKDQIDSSINLFKNSISSSIALAGKTAKINDDPQLTKACKTVKKSIIELTRLLKLNPLIEELSSYQQALLLKPHPINENIIKGFKEHQINSRYYIETAYQVGKDDLISQSIEKIVYQQSELLKLASNHLTSKEVSETLDPNIQLLLANSLETVKKSIVDQVEAALSFLESEKSDDQIEKLLTILDTVSESVDNCSKSIFFATGKGKQQQDLSPTTISQNTIKQSINSIIPTLTLQATQLQSNPNDKELEKKHQQLLDQIIQPLEQLILNPNINQIIDKENIENNNNNNNNDNNNNNDDDDDEEEDKKIKKLINDEKKELDKLESNALDSDSKGVVESSRSLVKLHQEILSLADSLTSSTAVLIDANQNNADFERNLIIKECSKELSTLIPLQLQTIKSMLQSKDIPTEASYQKKVGFINNQIKRNLNEIEKQSSNNNSNYKLISKTPYYSDQFKKLSNKIDNNGMLIKDENQFKVNLKRLEKLAGKCIDSSNFDLSRQQSYLDKERQQRIRDAINKLENKLNGKNNDSTDDLSNKINQYLKQPLNPISREQFEKVRSQFQQTLDNLINEQLSTPLQLLLNHSNLIQKLSRQSTQQPINNNNNANNNVKIQETTKKILENYSKLKQQLINNDIKLNESKKLIIGKSLKEIETLTPQLIVASNNCLNDNNNDQKKRELLENLQTKIESPIYEILNQLDSIDPIFQFKNAIKQYQATLIKLNDSIDVSTVTNDNSKQIDEYISKLSNLQSNHLIPLLKQQGLNEKELKEFESQLKSKLSDVNSISKDYLKNLKQSKLTDTIKAEKDMSISSLCNLINSIQSINQPKIEDNRIKLSQSSQSKSKDIKQLVDSIKSNNLLPIVESPNKIERYVSIQTNSTKPIFSSSSSNNGKIISTAQVNYKPRSSSQPQKPILTNTNNITITKPIRPIETRVPIKLTTQPQSTNPKTVPPTTTTTTEATTTATKPIPNKTPQPINTFKPSDKGASLEDSCINAANQMSNISGNEQLGTIGKELEAYANAIKIGDKKQILLCGRNISILLNKYSTEVSNNIKSTPTSNKMLQTRCSHGIGVLQTLSCQFKILSSVKAASDEKDSDSDSQLTSMVNQLTSTLLDLNTSTSTLNKFKK
Protein: Metalloproteinase inhibitor 2 (Tissue inhibitor of metalloproteinases 2) (TIMP-2) (P25785)
Organism: Mus musculus (Mouse)
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
Subcellular location: Secreted.
Interaction partners:
- Matrix metalloproteinase-14
- 72 kDa type IV collagenase
- Matrix metalloproteinase-9
- Collagenase 3
- Stromelysin-1
- Matrix metalloproteinase-15
- Matrix metalloproteinase-16
- Stromelysin-2
- Neutrophil collagenase
- Matrix metalloproteinase-24
Sequence:
MGAAARSLRLALGLLLLASLVRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPDKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSITQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKSINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
Protein: Inhibitor of growth protein (Q9VWS0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361213}.
Interaction partners:
- Chromatin modification-related protein MEAF6
- YEATS domain-containing protein 4
- Enhancer of polycomb-like protein
- NuA4 complex subunit EAF3 homolog
- MRG/MORF4L binding protein
- DNA methyltransferase 1-associated protein 1
- Transcription-associated protein 1
- RuvB-like helicase 1
- Brahma associated protein 55kD
- Bromodomain containing 8
Sequence:
MLYLEDYLEMIEHLPQELRDRFTEMRELDLAVQNNMDSLDKKAHMFFKQCKRDELQHESMDTEFHSLRGEYFKVMEDADEKVAIATQIHELVERYLRRLDSELFKFKCELEADNNGITEILERRSLELDGNSTAATALLLSMNQKENRYYGASSANTMVNSSTGHATGAATGSSGIALVSGAAGTGGALSSISTAQLGSSQRHRKLEKRRETICTVPVQEKRANLNHSLPVVGSGSTTAAAASSSSATTAAAAASLASATTAQTHVSNHIGSIAATHLTLPVAMGVAGGSSSLASSSLATGTGSLVRQLPTNLTHTVLSTSGGATAAAAAGGNSTSVVAAGTAHGHAHVSGHSAAGATVTYNLQQLGGGAAASSAIAAAASQAIVATQQMQQGRRTASLKASYEAIHGTAGTTTDFWTQAGQGGLQQSTAGSVTVAAGTALATGAAGGSSTGSHHSHHSQSHHGGHGHGHGHGHGHGHGHGHHSSSGHGGGHSSHHQEKKQKKKLTTALTLPTVQPTAGSSSGNSIGSSSSISLESVNKLTTSAALAAASATTTYMSVGGQALLAMTPGGGGGGNLAESSAEGVPAGMIAMNLPTTTVTPGSSLTIGENGLVVEQTNEGEWSYDPNEPRYCTCNQVSYGDMVACDNDACPYEWFHYPCVGITQPPKGKWYCPKCTASMRRRGNRKN
Protein: Carbamoyltransferase HypF (EC 6.2.-.-) (Carbamoyl phosphate-converting enzyme HypF) ([NiFe]-hydrogenase maturation factor HypF) (Hydrogenase maturation protein HypF) (P30131)
Organism: Escherichia coli (strain K12)
Function: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. In the absence of any other substrate, displays carbamoyl-phosphate phosphatase activity.
Interaction partners:
- Carbamoyl dehydratase HypE
- Hydrogenase maturation factor HypD
- Hydrogenase maturation factor HybG
- Hydrogenase maturation factor HypC
- Hydrogenase maturation factor HypB
- Hydrogenase maturation factor HypA
- Hydrogenase 3 maturation protease
- Hydrogenase-2 large chain
- Electron transport protein HydN
- Hydrogenase-1 large chain
Sequence:
MAKNTSCGVQLRIRGKVQGVGFRPFVWQLAQQLNLHGDVCNDGDGVEVRLREDPETFLVQLYQHCPPLARIDSVEREPFIWSQLPTEFTIRQSTGGTMNTQIVPDAATCPACLAEMNTPGERRYRYPFINCTHCGPRFTIIRAMPYDRPFTVMAAFPLCPACDKEYRDPLDRRFHAQPVACPECGPHLEWVSHGEHAEQEAALQAAIAQLKMGKIVAIKGIGGFHLACDARNSNAVATLRARKHRPAKPLAVMLPVADGLPDAARQLLTTPAAPIVLVDKKYVPELCDDIAPDLNEVGVMLPANPLQHLLLQELQCPLVMTSGNLSGKPPAISNEQALADLQGIADGFLIHNRDIVQRMDDSVVRESGEMLRRSRGYVPDALALPPGFKNVPPVLCLGADLKNTFCLVRGEQAVLSQHLGDLSDDGIQMQWREALRLMQNIYDFTPQYVVHDAHPGYVSSQWAREMNLPTQTVLHHHAHAAACLAEHQWPLDGGDVIALTLDGIGMGENGALWGGECLRVNYRECEHLGGLPAVALPGGDLAAKQPWRNLLAQCLRFVPEWQNYSETASVQQQNWSVLARAIERGINAPLASSCGRFFDAVAAALGCAPATLSYEGEAACALEALAASCHGVTHPVTMPRVDNQLDLATFWQQWLNWQAPVNQRAWAFHDALAQGFAALMREQATMRGITTLVFSGGVIHNRLLRARLAHYLADFTLLFPQSLPAGDGGLSLGQGVIAAARWLAGEVQNG
Protein: Bifunctional pinoresinol-lariciresinol reductase 2 (PLR-Tp2) ((+)-lariciresinol reductase) (EC 1.23.1.2) ((+)-pinoresinol reductase) (EC 1.23.1.1) ((-)-pinoresinol reductase) (EC 1.23.1.3) (Q9LD13)
Organism: Thuja plicata (Western red-cedar) (Giant arborvitae)
Function: Reductase involved in lignan biosynthesis. Catalyzes the enantioselective sequential conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol. Can also convert with a lower efficiency (-)-pinoresinol into (-)-lariciresinol, but not (-)-lariciresinol into (+)-secoisolariciresinol. Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
Interaction partners:
Sequence:
MEESSRVLIVGGTGYIGRRIVKASIALGHPTFILFRKEVVSDVEKVEMLLSFKKNGAKLLEASFDDHESLVDAVKQVDVVISAVAGNHMRHHILQQLKLVEAIKEAGNIKRFVPSEFGMDPGLMEHAMAPGNIVFIDKIKVREAIEAASIPHTYISANIFAGYLVGGLAQLGRVMPPSEKVILYGDGNVKAVWVDEDDVGIYTIKAIDDPHTLNKTMYIRPPLNILSQKEVVEKWEKLSGKSLNKINISVEDFLAGMEGQSYGEQIGISHFYQMFYRGDLYNFEIGPNGVEASQLYPEVKYTTVDSYMERYL
Protein: Nucleoside diphosphate kinase 1 (EC 2.7.4.6) (Nucleoside diphosphate kinase I) (NDK I) (NDP kinase I) (NDPK I) (P39207)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Plays a role in response to reactive oxygen species (ROS) stress.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19329564}. Nucleus {ECO:0000269|PubMed:19329564}. Cytoplasm {ECO:0000269|PubMed:19329564}.
Interaction partners:
- Thymidylate kinase
- Inosine triphosphate pyrophosphatase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- At5g66005
- Guanylate kinase 3, chloroplastic
- UMP kinase
- Guanylate kinase 2
- Probable UMP-CMP kinase 2
- Guanylate kinase 1
- Probable UMP-CMP kinase 1
Sequence:
MEQTFIMIKPDGVQRGLIGEVICRFEKKGFTLKGLKLISVERSFAEKHYEDLSSKSFFSGLVDYIVSGPVVAMIWEGKNVVLTGRKIIGATNPAASEPGTIRGDFAIDIGRNVIHGSDSVESARKEIALWFPDGPVNWQSSVHPWVYET
Protein: Inner membrane complex protein 1j, putative (C6KT52)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MEDKKHCTLTFNDWCKKKEKEDDGLNTGYINKYNEIYFNKDGKHNIYENINERPIINLEGDQPVFNVPVYQDKYIRDKIVECVNYEIQDVVQPTFYSQETKHDVPTVELLYKEKKVNIPQEKIIEKPVEVDMPIGYTPVFSPTWDVREIPRVIPKYEGEQKIIQVEIPQIKYVDKFVEKEIIVDIKEKIIPRINEVEKEIDVVKYKWKEKYQDVPVCKYVPKIDVELDCPPPLIVPYPAVHFHNTSEVMNPHQKALDIPSEVLLKNNNIFGYDINMNGNHRNVYNDSNMHNNNNNNNNIYNSSNNYNGMSNFHVDESVKKSLLDVARLTGVQKDNDAKYNEFMKNKNLERRKKKKNWPFCYFKKDTIKENDEMYNGQNYSNYQNNCCNSYKGEDENNYDIDPNTGYPKSMPKDFASFFKQDLNSVKKQMEKKTNTKSSYSSDFIEKSPVNPSIEYLGKVDKPPIDAGKLDSISFKLHAIEVHQFIPVPSLPKPRFLDLVPSQQYEQNDISSLQNVFGQVPEGWVDPQITGFIAPMMNDVLHGNIQPQSPLFNNLSTEGYDSSSKNRRTPRINAPSNIHNNNDSSNVFSFDHDNYHNEGGEGSFDQAYYDEYTNEKYDNEENEYHTEYIENNNDEDTNGYIKSPNDLTYNTDSSINEGKQNEDIN
Protein: Zinc finger protein 90 (Zfp-90) (Zinc finger protein NK10) (Q61967)
Organism: Mus musculus (Mouse)
Function: Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:21284946, ECO:0000269|PubMed:7576184}. Note=Colocalizes with REST in the nucleus. {ECO:0000269|PubMed:21284946}.
Interaction partners:
Sequence:
MAPRPPTAKPQESVTFKDVAVNFTQEEWHHVGPAQRSLYRDVMLENYNHLVSLGYQVSKPEVIFKLEQGEEPWISEKEIQRPFCPDWKTRPESSRSPQQGVSEVFLRTNVLSHTTIGDIWNVAIQGHQESGRRHLGPEASSQKKITTLEKKIEQNKVGEDSSLSTDLVPQLDISSSIRPSDCKTFGNNLEHNSELVTQSNILAKKKPYKCDKCRKSFIHRSSLNKHEKIHKGDPYSNGTDQGAQSGRKHHECADCGKTFLWRTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRSKPYQSNNFSLAFVPNTPLPQGEGLLTEVKSYHCNDCGKDFGHITDFSEHQRLHAGENSYGSEQTLLGQQSLSHPREKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRLSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECNECGRAFRKKTNLHDHQRTHTGEKPYACKECGRNFSRSSALTKHHRVHARNKLQES
Protein: Protein abrupt (Protein clueless) (Q24174)
Organism: Drosophila melanogaster (Fruit fly)
Function: Expression is vital for development; may be involved in transcriptional regulation. In embryos, muscle specific expression is required for segmental nerve b (SNb) motoneuron target recognition within ventral longitudinal muscles. Has a role in establishing and maintaining embryonic muscle attachments, adult sensory cell formation (macrochaetae) and morphogenesis of adult appendages (legs, antenna aristae and male external genitalia). Has a role in the morphogenesis of the class I dendritic neurons: selective expression of ab in class I da neurons plays a pivotal role in forming dendritic arbors, which are characteristic of the class I cells. The development of more complex arbors of class II-IV neurons depends on the absence of ab.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MTESTQLQTAENNNAGVVKMEPPPPATSSVSVSAAAAAHALSSLSSLTMAATGSALSPATPPPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKDLGVQLPNSNAPGQSLLDTYLQFITENTFGMGMSQEQAAAAALRAKMAQLNAMGHSLDNLPPGLLPGQFDLSKLAAGNPAFGQSGPGLTIEPIMRHEQAAGNLSPNRPLALNSGGRMMGHDEMAENDGDMRREGSEPMDLGLDNNQSGSNHEVANSDAEENYSEDEGVHNT
Protein: C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) (P61073)
Organism: Homo sapiens (Human)
Function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10452968, ECO:0000305|PubMed:20929726}; Multi-pass membrane protein {ECO:0000269|PubMed:20929726}. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Interaction partners:
- Inter-alpha-trypsin inhibitor heavy chain H4
- Stromal cell-derived factor 1
- C-C motif chemokine 21
- T-cell surface glycoprotein CD4
- Growth-regulated alpha protein
- C-C motif chemokine 5
- C-C motif chemokine 19
- C-X-C motif chemokine 13
- C-C motif chemokine 2
- Interleukin-8
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Protein: Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) (Q9UQ88)
Organism: Homo sapiens (Human)
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Cyclin-L1
- Cyclin-L2
- Matrix metalloproteinase-23
- RNA-binding protein with serine-rich domain 1
- Heat shock protein HSP 90-alpha
- Matrix metalloproteinase-21
- Cytoskeleton-associated protein 5
- Serine/arginine-rich splicing factor 7
Sequence:
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Protein: Glycoside hydrolase family 28 protein / polygalacturonase (Pectinase) family protein (Putative polygalacturonase) (O49319)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Pectin lyase-like superfamily protein
- rhamnogalacturonan endolyase
- Berberine bridge enzyme-like 9
- Protein DETOXIFICATION 13
- Berberine bridge enzyme-like 23
- Probable pectinesterase/pectinesterase inhibitor 59
- Protein DETOXIFICATION 15
- Probable pectinesterase/pectinesterase inhibitor 60
- Berberine bridge enzyme-like 27
- Probable xyloglucan endotransglucosylase/hydrolase protein 33
Sequence:
MASRVLLILCVPSLFFFLAASTKEYPGQPKIFDVRNYGARADSQRDNAFAFTKAWNEACQWSYGRSTVYIPSGIFYLRQVTFSGPCKSSITFFIRGTLLAPRNPYAINQEEWILFKYVDNLTVTGGGLLDGQGSYSWPLNDCNKNTNCRTLAMNIGFAFVKSSKINGLRSINSKMGHFNLFSVEDFNITGVTITAPGDSPNTDGIKIGKSSHMQIYNVTIGTGDDCIAILDGTSNLDISDVRCGPGHGISVGSLGRYKEEKNVQGLTVRNSIINGTTDGLRIKTWAKSVSQISVSNFLYENIQMINVGNPIVIDQQYCPHGQCDSPGKYASHVQIKDVKYNNIWGTSTSKEALKMQCSKTFPCQDVELSNINLHYVGRDGLVTALCENVGGSIRGKIVPANCRINLFLPSNIITDSNSTLEDKMQGIFQLANTTQTQRFHQLPLWILWRLWNSRNILYFQRRHVPWETTLQLAQMDLQEWNEAVTPSHINSHGTTIRSHIPNWRRPTNGWVKCNVDGSFINGNIPGKGGWIVRDHNGRYEFAGQAIGNCIDNALECEFQALLMAMQHCWSKGYRRICFEGDNKEMFDLINGLKMHFGAFNWIRDILWWASKFEQTQFQWTNRQNNKPADILARTPLQHQFLFANHFWVPRVISFALHCDYTSSI
Protein: Sperm surface protein Sp17 (Sperm autoantigenic protein 17) (Q62252)
Organism: Mus musculus (Mouse)
Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Calcium-binding tyrosine phosphorylation-regulated protein
- Ropporin-1-like protein
- Ropporin-1
- A-kinase anchor protein 3
Sequence:
MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFENLLEKREKTSFDPAEWGAKVEDRFYNNHAFKEQEQVEKCEQELAKSSGREETPVTPFEESTEEEREQEEAAALKIQSLFRGHVAREEVKKMKSDKNENLKEEADN
Protein: Histone-binding protein RBBP4 N-terminal domain-containing protein (Q386K4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Peter pan protein, putative
- Nucleolar complex protein 2
- Small-subunit processome Utp21 domain-containing protein
- Ribosome assembly factor mrt4
- Periodic tryptophan protein 2, putative
- Uncharacterized protein
- rRNA biogenesis protein, putative
- ATP-dependent DEAD/H RNA helicase, putative
- Bystin, putative
Sequence:
MRKAAKRVERTEDTTSSERKHRRCVEEDEEGGQRLRAAGTRKEGPTEDEDWEDVSEDEESDGSNSSGVDEPFNDGVEEEIVDSYDEDDEDYAEFQREAEAMVKGLRKVTFDDDSTKQENDEDDTVPTVWRSDCVDDPEGQCQKLDYSNKAYDSFFQLRTEYPSLSFHVVREQESSTGGGCTTKYPLSLTLVCGSQAEESSKNQLYILRVTNICRTKHDAGSDSDSDDSYIGDEGESEDSNEDEAPEVNNGEPIVHHRTISHHGTANRIRCAHRNQNLVAVWSDAGNVQVFDIAKEIGMLCDYPNWIKEQVRSGAQRKQASLLFCTPSTSHKTEGYGLDWSSVSEGVFASGDCNGDLFVWKPTEDGRWTAVASNTVGSEKGAPSVEEVQWSPTQTDVLIATRVGGTVEVWDTRDMRGSKIHWQADPTDINVANWNKALQASHLLVTGADSGAVAVWDLRHVSSGVPIQQLPWHRGSITSVEFSLHNESVLAVAGDDGQCTLWDLSLERDPSEEQEVVGELFGRPDLSGIPDQLMFQHQGLEHPKEAHWHPQIPGMMITTDYAGLHLFRPMNWRSLMK
Protein: DNA nucleotidylexotransferase (EC 2.7.7.31) (Q5EB91)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR000817}.
Interaction partners:
Sequence:
MDPLQAVHLGPRKKRPRQTGASGASTPHDIRFRDLVLFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQLQNIKASSEFELLDISWLIECMGAGKPVEMAGRHQLVVRRNPSLSPVPGSQTVPPPLMQKISQYACQRRTTLNNHNQLFTDAFDILAENYEFRENEVSCLPFMRAASVLKSLSFPIVSMKDIEGIPCLGDKVKCVIEGIIEDGESSEVKAVLNDERYKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIKSDKSLRFTHMQKAGFLYYEDLVSCVNRAEAEAVSMLVKEAVVAFLPDALVTMTGGFRRGKMTGHDVDFLITSPEATEEEEQQLLHKVTNFWRQQGLLLYCDIIESTFEKFKLPSRKVDALDHFQKCFLILKLHRGLVRSEESGQQEGKDWKAIRVDLVMCPYERRAFALLGWTGSRQFERDLRRYATHERKMMLDNHALYDKTKRVFLEAESEEEIFAHLGLDYIEPWERNA
Protein: Annexin A11 (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) (P97384)
Organism: Mus musculus (Mouse)
Function: Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner.
Subcellular location: Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}. Nucleus envelope {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.
Interaction partners:
- Protein S100-A6
- Annexin A7
Sequence:
MSYPGYPPPAGGYPPAAPGGGPWGGAGYPPPSMPPIGLDNVANYAGQFNQDYLSGMAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPPYGMYPPPGGNPPPGMPSYPAYPGAPVPGQPMPPTGQQPPGAYPGQPPMTYPGQSPMPPPGQQPVPSYPGYSGSSTITPAVPPAQFGNRGTITAASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDVYEIKEAIKGAGTDEACLIEIFASRSNEHIRELSRAYKTEFQKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSELDLLDIRAEYKRMYGKSLYHDITGDTSGDYRKILLKICGGND
Protein: Uncharacterized protein F15G9.1 (Q10033)
Organism: Caenorhabditis elegans
Interaction partners:
- GEX Interacting protein
- Protein-tyrosine-phosphatase
- ANK_REP_REGION domain-containing protein
- Cysteine-rich protein 1
Sequence:
MSSRYTSSYTPSSRYGSGWDYSSSYSSSRTSRDRDTGSYRDRDYSSTSYTSTRPRYSTYASKYSTDLGKSTDKGMDDYSAAPIAKDEIEELSYDAKTPTTPTEETVDAPREVLQESQISDFVEEDDDQQTEVEEVKLTLASEPEESEEEEDDEDVRKAQELLAASTQIRESSPVSSPVKEVSSAASLFANDNGNETENRTPSPTVLNAKKLGGIPWPPKSSDVKKEGGDAEALPKKRVSDLIARFNTGVVEESKKTDDAYKNEYGAGTNVGKVSTHNFA
Protein: CST complex subunit CTC1 (F4JKR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MENTTILTVKDLVNEGIAVTGASSLFSSAASHSSSESTSTNPKSHPGAVDSDFSRKFLTPLNYPTVIFGTVALPSETLKCPNRYCFRFTDGDLTICCDILGFEFRAIGSKICVLSWNFLPMNHSGGFLEIINWKFVDSGSLLSRCSGISSFPLIPSLYSSQNGDRKSRYSVCGVLESISPVSVVPCMDGVSSDSVNLPGFLVHVMACECKVYSRDAIDCGHAFERSVFVYFCGLEAASWHPVVMKLVGRNVALSGLKRKLVYVRGDSLLVFVTTENSVLHPPWLSKKGTVSKTVVDRRGNCGSYRGYVRGLYLKGKLVEMDEDVWLLLTDQILNRSHSIRTGSLIFIRNVHFVNTKFPWGEVLILGACFKTSITVEFFSPFETSCLVDSCRQTSLSLYVESLSFPARLWTLLVRISFEKFNRMPSDKEILRSCQKDELTKMYAESRIPPSMFQPRGGIFTEFCMHESCGCNSEARDCNLKLVMPISSFVHHVKVMLNELLSQIKKDFSASDCLSHSSSTWKRYNNTNPKTLRSEDTGVILLGRLKISSSGRLQLHDRTSSIDVLTPDLLSDRNASRICEVPDYYLIIEGIPESMLHMPFLKNPFRCSSVLNPTPLAIKNTLTVPFSLSLGTASCKHLLKHHPFDWRHDFNEFKEGFFHLFRVTHKFPILKNGHPGMPDCTSVFIEALVLPWDLICTVTEEEAAAPNFEEHDTSQEIRPHKRCKTNNGLQSQSFLSVPHEISCQMTIRCASSHCLVATATLSNLTENKSGKMHSAMRVLLEFIPECSNYYGLQIGGCYLMKHGSDDSFCVGRSGISNNDKINFRPETRLWSLEFSFDEVLTHDGSMDVHPLVSSQPSFAVEQQNVSSRQPCSDVSLLLPYDAKGLFSVFLNDLEGLNKPLAAGKDNNNISCCTQSETIMHAEPSRLLPSNSLFPEGNLATFRGDVVAVDAVTSSVVDVSSSYCINVLVNHQMVKIFGPLRRHSYLTGFGFGTNATFYRILGTGEQNSFVLTSASFIKINSRKALDSPPLEKPTHGAALCLPKITPQEFVPCILAGPACNSFSGNEDNQQIKFACKQQVLSVYLLVLQTRSDDPSENECRNNIDIPLAGFVVDDGSSTYLCWTSGERAFTILRLHEELPEETIDVVQWTRRYSNWGTTAYHLDQIVRVHKRIVMKCNGSQIDVLFQDITIAVTSDQLLTKSEDKFLKWLILNAISGPIWEVAASSMDMKMIEHLEREQCVEMETSRYNLQSVWGNEVCQVDPLVRAWSLLQGLLNS
Protein: Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) (Q3TY86)
Organism: Mus musculus (Mouse)
Function: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity).
Subcellular location: Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis. {ECO:0000250}.
Interaction partners:
Sequence:
MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVTIRASKQALQLQRRTKVMAKCISPSAGHSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDVENVFTIRTPEDANRVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRAQEGKLQEVVLKSSKVLRADVCVLGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKSDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS