wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase PBS1 (EC 2.7.11.1) (AvrPphB susceptible protein 1) (Q9FE20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein kinase required for plant defense mechanism mediated by the disease resistance (R) protein RPS5. In case of infection by Pseudomonas syringae, AvrPphB triggers RPS5-mediated defense mechanism via the cleavage of PBS1. Both kinase activity and cleavage by avrPphB are independently required to trigger the RPS5-mediated resistance. Contributes to PAMP-triggered immunity (PTI) signaling and defense responses downstream of FLS2.
Subcellular location: Cell membrane; Lipid-anchor {ECO:0000269|PubMed:22046960, ECO:0000269|PubMed:24225654}.
Interaction partners:
- Disease resistance protein RPS5
- RPM1-interacting protein 4
- Disease resistance protein RPM1
- Disease resistance protein RRS1
- Elongation factor Tu, chloroplastic
- Cysteine and histidine-rich domain-containing protein RAR1
- Toll/interleukin-1 receptor-like protein
- LRR protein
- Protein EDS1
- Protein DMP1
Sequence:
MGCFSCFDSSDDEKLNPVDESNHGQKKQSQPTVSNNISGLPSGGEKLSSKTNGGSKRELLLPRDGLGQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQNLVAWARPLFNDRRKFIKLADPRLKGRFPTRALYQALAVASMCIQEQAATRPLIADVVTALSYLANQAYDPSKDDSRRNRDERGARLITRNDDGGGSGSKFDLEGSEKEDSPRETARILNRDINRERAVAEAKMWGESLREKRRQSEQGTSESNSTG
Protein: Uncharacterized RNA-binding protein C25G10.01 (Q10422)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor srp2
- Uncharacterized protein C683.02c
Sequence:
MDTLPPATSEESFEIPNADVAGSAVLETETSQDIHQLEIEKDAGETDSDAGSIAMNVHQLDTAGEPLQSMNEDEVDPNNESTALDKKEPQSAPEGSENLGNDLFVSGIASRMQEDELQQIFSKFGTVTHVRIMREPVTKASRGFGFLSFSTVEEATSAIDNLNSQEFYGRVLNVQKAKRSRPHSPTPGKYMGYDRRRNSRDFPSNNKDGGYRRNNYRDRDSNRYRNSYRPSRPQREHSPGNYRKERYNVDSRPRRERHFHGRSFAHAEHHSVPNMRNDTPGNEALPSHSSVPPNEDQ
Protein: Zinc finger protein 157 (Q6PCM4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGLVSFEDVAVDFTWQEWQELDAAQRTLYRDVMLENYSSLVSLGHCVTKPELILRLEHGFQPWSIGDTSVWRLPGVLEVYTPNESCLENAESRMWPVGSINRNLSNKEMIEAEMKVQLELPRGTKPYECKPCMKMVSLPSQCSKQHAYYPSVKPYEWKECQKAFCYKSALTQHQRARTRLKIYQCTECKKAFSSKSELTVHHRIHTGEKPHACEECGKAFYRKSTLTVHQKTHRGEKPYECKECWKAFYYKSTLTEHQRIHTGEKPYVCKDCGKAFFYKSNLTRHHRTHTREKPYECKECRKGFSSKSELTSHHRTHTGEKPYQCEECGKAFYCKSTLRVHQKIHSGEKPYECKECQKSFYYKSTLTEHQRTHTGEKPYECKDCGKAFFYKSQLTRHHRIHTGEKPYECEECRKAFSSKSELTAHHRTHTGERPYECKDCGKCFYRKSHLTLHHRIHTGEKPYECKDCRKAFFCKSGLARHLGTHTHGTNTKNREKHFPATHSSVNIRNDIQVRNPVALNNEKKLSTINHSSVHMMDFLELRSPIDVHNAGKLTFLTHASFNVNELR
Protein: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)] (Q9Y223)
Organism: Homo sapiens (Human)
Function: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35826}.
Interaction partners:
- N-acetylneuraminate-9-phosphate synthase
- UDP-N-acetylhexosamine pyrophosphorylase
- E3 ubiquitin-protein ligase RNF38
- N-acetylneuraminate lyase
- N-acylglucosamine 2-epimerase
- UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
- Dihydropyrimidinase-related protein 1
- Glucose-6-phosphate isomerase
- GDH/6PGL endoplasmic bifunctional protein
- N-acetylglucosamine-6-phosphate deacetylase
Sequence:
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIY
Protein: AT5g12260/MXC9_22 (Glycosyltransferase family protein 2) (Transferring glycosyl group transferase) (Q9FMN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RNA polymerase I specific transcription initiation factor RRN3 protein
- RNA polymerase I specific transcription initiation factor RRN3 protein
- RNA polymerase I specific transcription initiation factor RRN3 family protein
- Probable disease resistance protein At1g61310
- Probable disease resistance protein At1g61300
- Putative disease resistance protein At4g10780
- Probable disease resistance protein At1g61190
- Probable disease resistance protein At5g47250
- Cationic amino acid transporter 1
- Putative disease resistance protein At5g05400
Sequence:
MVSQSRRRNPTLRSMAMVFAQPKKNLLPLILFLFCISVIILLVLVSETTHSNAGRGTTFRRNYNDPAPFTFLIKVLTFNRLHSLSRCLRSLSAADYGVSGDRGRIHLHVYIDHFNLARNDTPVEDNLQIAREILGFVDRFEWRFGEKVVHYRTDNAGLQAQWLEAWWPISDHEFAFVVEDDLEVSPLYYGILERLILKYYYDTSNFNPSIYGASLQRPRFVPGKHGNKLHVDPKTNLILYQLVGTWGQLLFPKPWKEFRLWYDEHKSKGKKPFLDGMVSNGWYKRLGERIWTPWFIKFVHSRGYFNIYTSFPNEGALSVSHRDAGVNYGRTAGPDSQLLNKSSLSSDSLKLQPLSNLKWYDFCFSEVVPGRVVRNLNELGTILPSVQREKTIILVSLYGADKMFIRNLLCHFEKLNIQNHIFIGPSSELFHDLSRRGHPVIDADMFLNKLIKSKTSYPNSVKEALGNSYVVKKCLELGYSTWAFSSNSLLVDKGRLLDRVSSDYDIYIGESSGILIVQSSSVTQKLWSNEFLHSIASPKQSLDFIHLVKELVEQKGKRIKTVETMNIAENTNANSVNQSLGDGKPVVYWSPEVAPNMIRSKLEELSLWLIDDDLSCKAVVCHSS
Protein: KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1) (Q5VWX1)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9WU01}.
Interaction partners:
- Protein-tyrosine kinase 6
- RNA-binding motif protein, X chromosome
- KH domain-containing, RNA-binding, signal transduction-associated protein 3
- Lambda-crystallin homolog
- Protein arginine N-methyltransferase 1
- Heterogeneous nuclear ribonucleoprotein K
- RNA-binding protein 3
Sequence:
MEEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGIRGRGIRIAPTAPSRGRGGAIPPPPPPGRGVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGYGGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQRSARGGYREHPYGRY
Protein: NAC domain-containing protein 23 (ONAC023) (OsNAC6) (Protein THERMOSENSITIVE MALE STERILITY 5) (Q6H8A9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in the regulation of seed size (By similarity). Binds to DNA-specific sequences of CLPD1 and OAT promoters in vitro.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}. Cytoplasm {ECO:0000269|PubMed:27872632}.
Interaction partners:
- Os04g0589400 protein
Sequence:
MAMTPQLAFSRMPPGFRFQPTDEQLVVDYLQRRTAAQPCVTPDITDIDVYNVDPWQLPAMAMYGSDHDRYFFTMAAREAQARRTTPSGFWKPTGTKKTIFVVAGGHEVPTAVKRRFVFYLGHHQPSGSNNNNKTSWIMHEYRLMNSPRAAVPSSSSVNRLPTDDLTEEMVLCRISNKDLPKPPFIHNSLLQFSSVGLNGDGYNYLILDHLEPPAMEYPNVGIGNVDDAAAGTDDPGDLDEEIDDSMQRNHGG
Protein: LD40758p (Ras association family member) (Q9VCQ7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serine/threonine-protein kinase hippo
- Scalloped, isoform Q
- Scaffold protein salvador
- GH01133p
- Transcriptional coactivator yorkie
- Serine/threonine-protein kinase Tao
- Connector of kinase to AP-1, isoform E
- Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform B
- FGFR1 oncogene partner 2 homolog
Sequence:
MWKCHKCGKPVYFAERKQSIGYDWHPECLRCEECGKRLNPGQHAEHKSVPYCHVPCYGALFGPQLFGHGTRVESHKSYGVKGAQKPTGAQANGPPLPRDHLESKLKVYNQFYDNKSLEIRSREVNNRLVLEGALRVYWGVQGVIHLKEDDDQRILVRKRNSCRVSKAANESSSDKENEASESLAPPTTTTAEVDQLSTDVSLSESMTFDSCSLNEISELPTTPEDASANTTANSKEQTNGNVCNDDEDTTTTDSSGTLVEAPTASTSCVSSTLPSKLDRLEKLDWDDIDDLLQVERRHNDKDRIYETMPVKLPSSQSSSDSSPSKTSTETTTTTESSSTQSASTNTSSTDDFMTATGSLTANTNTQNTTTVSTTETSLDNFETCDDATLKPIDFEDFKRSVHQDYVNGANSFTEPNEGTLKRNQPIDPSRIHDSLKLYGENSAMSKSFNCEHALRSIDPTLINDTMNLRSSVGSPHSAQRQYALQKSGSATVTSRDQKKPYQQGRQLFEKGINRSKSGPSCFVYSDSDDDDEATLRPQRMATIRRSDIPQRYIQIQMDCYPKENVAAASEGESSRADAPSITSGAAAGDELTQTEDLYTASEGVDGPDGDGSAGLHVTEDGVVLRRPPRTGASAIKRRSGNRRSRTKLKRRCSINGHYYNRETSFFTPPYGSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRLKDDEYPLITRVTLGPHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECRAILERYDQELAREVAKIKERYAELRRRIVSRMESLKVHL
Protein: Putative transposase YkgN (Q79E92)
Organism: Escherichia coli (strain K12)
Interaction partners:
Sequence:
MSGKRYPEEFKTEAVKQVVDLGYSVASVATRLDITTHSLYAWIKKYGPDSSTNKEQSDAQAEIRRLQKELKRVTDERDILKKAAVDSICQCNTPFNYLFRCFELQCLSRSVV
Protein: Serine/threonine protein kinase, putative (EC 2.7.1.-) (Q582S9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPEGEQAIGNYVIGKTIGKGSFGKVKEATHIPTGHTVAVKMINRDRLEHAKMDEKVAREIKILQLFSHPNICRLYEVIYTTTEIFLIMEYVECGELFQHIVNQGKLRENEARYIFQQIICAVNYCHNFLVAHRDLKPENILLGPGLQVKLIDFGLSNIAKDGEFLQTSCGSPNYAAPEVIDGRYYVGSNTDIWSCGVILYALLCGSLPFDESDTPSLFRKIKSGSYKIPAHVSSGARDLIEKILVVDPVHRLTIPQIYNHQWFVTNLPARLWPADPRRVDEQKRIS
Protein: Antiholin (Gene product 14) (gp14) (Lysis inhibitor 14-131) (Protein p14) [Includes: Holin (Lysis protein 14-129)] (P11188)
Organism: Bacillus phage phi29 (Bacteriophage phi-29)
Function: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space (Probable). Determines the precise timing of host cell lysis (By similarity). Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell (By similarity).
Subcellular location: Host cell inner membrane {ECO:0000250|UniProtKB:P03705}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P03705}. Note=Classified as a class I holin. {ECO:0000305}.
Interaction partners:
Sequence:
MKMIAWMQHFLETDETKLIYWLTFLMVCMVVDTVLGVLFAKLNPNIKFSSFKIKTGVLIKVSEMILALLAIPFAVPFPAGLPLLYTVYTALCVSEIYSIFGHLRLVDDKSDFLEILENFFKRTSGKNKEEK
Protein: Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) (Scube/You) (Q9JJS0)
Organism: Mus musculus (Mouse)
Function: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9NQ36}. Cell surface {ECO:0000250|UniProtKB:Q9NQ36}. Note=Secreted and tethered at the cell surface. {ECO:0000250|UniProtKB:Q9NQ36}.
Interaction partners:
- Sonic hedgehog protein
- Cell adhesion molecule-related/down-regulated by oncogenes
- Indian hedgehog protein
- Desert hedgehog protein
Sequence:
MGVAGCGRPREARALLLLLLLLPPLLAAAVPPDRGLTNGPSEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDMDECDNTLNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDMDECLENNGGCQHICTNVIGSYECRCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCGHICKEAPRGSVACECRPGFELAKNQKDCILTCNHGNGGCQHSCEDTAEGPECSCHPRYRLHADGRSCLEQEGTVLEGTESNATSVADGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPTGFTLQVDGKTCKDIDECQTRNGGCNHFCKNTVGSFDCSCKKGFKLLTDEKSCQDVDECSLERTCDHSCINHPGTFICACNPGYTLYSFTHCGDTNECSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDCVEVKGFPPTSMTPRVSLHCGKSGGGDRCFLRCRSGIHLSSDVVTVRTSVTFKLNEGKCSLQKAKLSPEGLRPALPERHSSVKESFQYANLTCSPGKQVPGALGRLNAPKEMFITVEFERETYEKEVTASCNLSCVVKRTEKRLRKALRTLKRAAHREQFHLQLSGMDLDMAKTPSRVSGQHEETCGVGQGHEESQCVSCRAGTYYDGSQERCILCPNGTFQNEEGQVTCEPCPRPENLGSLKISEAWNVSDCGGLCQPGEYSANGFAPCQLCALGTFQPDVGRTSCLSCGGGLPTKHLGATSFQDCETRVQCSPGHFYNTTTHRCIRCPLGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRKCGGELGDFTGYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
Protein: urease (EC 3.5.1.5) (D3UJ81)
Organism: Helicobacter mustelae (strain ATCC 43772 / CCUG 25715 / CIP 103759 / LMG 18044 / NCTC 12198 / R85-136P) (Campylobacter mustelae)
Interaction partners:
- Urease subunit beta
- Urease subunit alpha
- Urease subunit beta
- Urease accessory protein UreG
- Putative urease accessory protein UreH
- Urease accessory protein UreF
- Hydrogenase isoenzymes formation protein
- Urease accessory protein UreE
- Arginase
- Bifunctional enzyme IspD/IspF
Sequence:
MKLTPKEQEKFLLYYAGEVARKRKEEGLKLNQPEAIAYISAHIMDEARRGKKTVAQLMEECVHFLKKDEVMPGVGNMVPDLGVEANFPDGTKLVTVNWPIEPDDFKAGEIKFASDKDIELNAGKEITELKVTNKGPKSLHVGSHFHFFEANRALEFDREKAYGKRLDIPSGNTLRIGAGETKTVHLIPIGGSKKIIGMNGLLNGIADDLHKQKALEKAKHHGFIK
Protein: Forkhead box protein I1-ema (FoxI1-ema) (Ectodermally-expressed mesendoderm antagonist) (Xema) (FoxI3) (Q7ZYQ0)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional activator. Activates ectoderm, in addition to inhibiting mesoderm and endoderm formation; required at the blastula stage for normal formation of both the central nervous system and epidermis, the two early derivatives of the ectoderm. In addition, also required to maintain the regional identity of the animal cells of the blastula, the cells that are precursors of ectodermal structures. Also plays a role in differential adhesion, which limits cell mixing as primary germ layers become specified.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MSAFDPQAHSPPRCGPQFPSIGQEPPEMNIYCESFLHPQTMPSPQRPSNFETGDYSTTANPYLWLNGPSITPPPYLPGSNSSHFMPQAYGMQRQLLPNMHGLGSSELGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSPNGQLSSDKPEGSPLSESPTNGEHQDMLGNSSPGTDDSPEKRSPPPSITPCLNNFLSSMTAYVNSATPISRSVPLGLSNETSDKMGQNMVGFNSYTPLSNMPSHGGSDWSSTVSSNPFGYSSSVFNQFTPHFYNSMSTNNTLYNREGTEV
Protein: Protein late bloomer (Q24188)
Organism: Drosophila melanogaster (Fruit fly)
Function: Facilitates synapse formation.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Synapse.
Interaction partners:
Sequence:
MGCATTSVKIASIVLNAVLGFLAAGAIGWIAYNADTETEEFVIAAYIACSLILVFALLGIFAAIRESVVLTATSAVFLLILAILQIVSTCLFLHEFDVKSGRDMVEVAWQANNMDSLQQKHECCGQSSAQDYIHLSLLIPPSCYADLQQTPDHLYLDGCIEKVQSFYESDKLRFIIVSWVLVAFELICFALAVFLAISFKNKQRRMEF
Protein: 4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase) (Q383Z3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane {ECO:0000256|HAMAP-Rule:MF_03189}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03189}; Matrix side {ECO:0000256|HAMAP-Rule:MF_03189}.
Interaction partners:
- Farnesyl pyrophosphate synthetase, putative
- Farnesyl pyrophosphate synthase
- squalene synthase
- Cis-prenyltransferase-like protein
- ATP synthase subunit beta
- Alkylglycerone-phosphate synthase
- FAD-binding PCMH-type domain-containing protein
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Sequence:
MLRRTIFLGRVTRSWTKGSIVKASAHFPDSVRADPAERRNEDSSPKESRTWSLHDGPCSEPLHVPKHIQWATQKVRVWGQLMRVDKAAAINLLLQPCYWGASLAVTRAIVWEGADPVVLFAPFIPVHLIVLFGAGAFLARGAGCIINDMCDRKFDRMVERTKTRPLASGVVSMKEASGLLITVAGFALVIALNLSPMALASAVALAPIAAVYPLMKRITYMPQLVLGLCFNGGIFVGYAAVLNRIDLAVTLPIYCSAVVWTVLYDTIYAYQDRADDLKCGVKSSAILIGDRKHILTFMILPIGMGILISGLMVSQSLPFYIGVLCCVWYLQGVVDNVNIYDAWSCGMGFRRNVRFAILVTFSLCLGNVLWALASEHQPEKDAASNAISEKSALMKFLLLNKEAEPMSYSVQDIRWVDRFAHPAFVAAQKAQHEGEEKTVVVPAWMRREYLGENVGTIMRFFGVDEEAIQTWQKWWYAQLDHYNMFSSIAV
Protein: Leucine zipper putative tumor suppressor 1 (PSD-Zip70) (Q8CFC9)
Organism: Rattus norvegicus (Rat)
Function: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12415013}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000269|PubMed:12415013}. Postsynaptic density {ECO:0000269|PubMed:12415013}. Synapse {ECO:0000269|PubMed:12415013}. Note=Associated with the plasma membrane and with microtubules (By similarity). Detected in dendritic spines, especially in the postsynaptic density. {ECO:0000250}.
Interaction partners:
Sequence:
MGSVSSLISGHSLHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDMGGQTGVDFDPATPPKLMPFSSQLEMSSDKAAVRPTAFKPVLPRSGAILHSSPESTNHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKVEKGSSCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPASQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQMEVNAKASEILSLKAQLKDTRGKLEGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELLELRAQAALHRDAAPLGPPGIGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDIAGEPFEIDLEGADIPYEDIIATEI
Protein: Cytochrome c oxidase subunit (Cytochrome c oxidase polypeptide VIa) (H6SG15)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLKSHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE
Protein: Mitochondrial outer membrane protein porin 4 (Voltage-dependent anion-selective channel protein 4) (AtVDAC4) (VDAC-4) (Q9FKM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant growth and development at the vegetative and reproductive stages. Is important for leaf and pollen development and mitochondrial membrane potential steady state. May be involved in disease resistance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}. Mitochondrion outer membrane {ECO:0000269|PubMed:19326079, ECO:0000269|PubMed:21705391}. Note=Also localized in other unidentified cellular compartments.
Interaction partners:
- Mitochondrial import receptor subunit TOM40-1
- Probable mitochondrial import receptor subunit TOM40-2
- Large ribosomal subunit protein mL101
- Oxaloacetate tautomerase FAHD1, mitochondrial
- Mitochondrial substrate carrier family protein
- Kinesin-like protein KIN-14F
- Pentatricopeptide repeat-containing protein At1g80270
- Large ribosomal subunit protein eL39y
- F13O11.17 protein
- Probable transmembrane GTPase FZO-like, chloroplastic
Sequence:
MGSSPAPFADIGKKAKDLLNKDYIFDHKFTLTMLSATGTEFVATGLKKDDFFFGDISTLYKGQNTIVDLKIDSHSSVSTKVTLKNLLPSAKAVISFKIPDHKSGKLDVQYVHPHATLNSSIGLNPTPLLDLSATIGSQNVCLGGEVSFDTASSSLTKYNAGIGFNNQGVSAALILEDKGESLRATYVHTVNPTTSFGAELIRRFSNYNNSFTVGSSHSVDQFTVVKTRFSNSGKAGMVVQREWRPKSHITFSAEYDSKAVTSSPKLGLALALKP
Protein: Vacuolar membrane protein YNL058C (P53947)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Single-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 5'-deoxynucleotidase YGK1
- Uncharacterized protein YPR063C
Sequence:
MVKKNFIPSVSLVRRDLPTLVTTTTSSTALSKPTSSVVSETSSKSLPSLTSSAFSTSSGATSSSSLIVASITPPSTAGNPFILNAADKPNGTVYIAVGAVIGAIFISILIWWLVSSYLSRRFTMTNSYANDSKNLYRGHHKHSSSLQSNPFDINDEKSYMQDDWDSMSQLESSQYEDAASPFNPIQDPFTDNRRSLFISPTLQVSQYEKSHSRHQSKDTNIFIDDPFLYVGTYLEEEEEEEEERKLNLNRPQRAASPERKEKKINSMEGYHKRNQSSLGLIPVASATSNTSSPKKAHKRQAPSMFLDDVLNGREII
Protein: MTOR-associated protein MEAK7 (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) (Q21342)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lysosome {ECO:0000256|ARBA:ARBA00004371}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- V-type proton ATPase subunit e
- V-type proton ATPase subunit D
- V-type proton ATPase subunit S1
- Probable V-type proton ATPase subunit G
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit
- Ribonuclease kappa
- V-type proton ATPase subunit C
- Ribonuclease kappa
- V-type proton ATPase subunit B 2
Sequence:
MGAQNSKRKDLKNINDEDYAHFMEKLKKHTDGKDKMTRDQFVAMFIPILGEYSSQFYFRLVKNEPQGVLLAKTILKCIDTGLGHFDQLADMLRFCFGDQKDQIMRNVVKIFCEGNKFTREDQVRLYDYFETENTKPVSELESFFSMCPLFAYCASFIFQRLLDKTGDSKMPILSDKTHLMGNIDQLVLNSHLPFDRRKNWTLLYSNMKHGQSFSQLVKCINGEGPCMIVIRSMKGRRFGFFASQGFLAGPQYRGTAECFLFQLAPKIATFDATGRTENYVYLNYQQQQHPNGLGIGGTESVWPLFIHEEFGGGTCQKNSSSFEPCHIAEEDEFKIKTIEAWRPGDKPQKSFEEQILLEERSPEKSIIDKDPEARAVLELAGKSMHSEAYRDPAPLLDGE
Protein: MICOS complex subunit MIC13 (Protein P117) (Q5XKP0)
Organism: Homo sapiens (Human)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101, ECO:0000269|PubMed:27184847}; Single-pass membrane protein {ECO:0000255}. Note=Enriched at crista junctions. {ECO:0000269|PubMed:25997101}.
Interaction partners:
- MICOS complex subunit MIC26
- MICOS complex subunit MIC27
- MICOS complex subunit MIC25
- MICOS complex subunit MIC19
- MICOS complex subunit MIC60
- MICOS complex subunit MIC10
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 5
- Metaxin-2
- Sorting and assembly machinery component 50 homolog
Sequence:
MVARVWSLMRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK