wanglab/gogpt-training-data huggingface dataset:
Protein: Prostacyclin synthase (EC 4.2.1.152) (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (Prostaglandin I2 synthase) (F1SBE5)
Organism: Sus scrofa (Pig)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
- Thromboxane-A synthase
- Prostaglandin G/H synthase 2
- Prostaglandin G/H synthase 1
- Prostaglandin E synthase 3
- Prostaglandin E synthase 2
- Prostaglandin E synthase
- Prostaglandin-H2 D-isomerase
- Hematopoietic prostaglandin D synthase
- Prostamide/prostaglandin F synthase
- Terpene cyclase/mutase family member
Sequence:
MSWAVVFGLLAALLLLLLLLLLTRRRTRIPWLGYALEFGKDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDSVVWEPRTKLDFHAYAVFLMERIFDVQLPHYNPGDEKSKMKPTLLHRELQLLTEAMYTNLRTVLLGDTMETGSGWHEMGLFDFSYSFLLRAGYLTLYGVETPPWTQESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSVGDKDRVCRVKGRLWKLLSPARLATRAHRSKWLESYLQHLEEMGVSEQMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELEPILSRAEQPISQMTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVADLALPMADGREFTLRRGDRLLLFPFLSPQKDPAIYTDPEVFKYNRFLNPDGLEKRDFYKDGKRLKNYSLPWGAGHNQCLGRAYAVSSIKQFVFLVLAHFDLELSSPDVEMPEFDLSRYGFGLMQPERDVSIRYRLRA
Protein: Protein SVP26 (Sed5 compartment vesicle protein of 26 kDa) (P38869)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16107716, ECO:0000269|PubMed:20236934}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16107716, ECO:0000269|PubMed:20236934}. Note=Early Golgi.
Interaction partners:
- Probable mannosyltransferase KTR3
- ER-derived vesicles protein ERV14
- ER-derived vesicles protein ERV41
- ER-derived vesicles protein ERV29
- Golgi apparatus membrane protein TVP23
- ER-derived vesicles protein ERV46
Sequence:
MLLELISYAGTVSGFLFLTLSIASGLYYISELVEEHTEPTRRFLTRAIYGIILILILLLLLDGFPFKLTLFSIACYIVYYQNLKSFPFISLTSPTFLLSCVCVVLNHYFWFKYFNDTEVPPQFKFDPNYIPRRRASFAEVASFFGICVWFIPFALFVSLSAGDYVLPTTSEQHMAKKNDDITTNNQPKFRKRAVGLARVVINSVRKYIYSLARVFGYEIEPDFDRLAV
Protein: Histone H2B 3 (Q6PC60)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2A
- Histone H3.3
- Histone H3.2
- Histone H3
- Histone H2A.V
- Histone H4
- Histone H4
- Histone H3
- Si:dkey-108k21.24.
- Histone H2A
Sequence:
MPEPAKSAPAPKKGSKKAVTKTQKKGDKKRRKTRKESYAIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: DnaJ heat shock protein family (Hsp40) member C21 (A0A2R8Y534)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIAKEELESVLEEEVDDFPTFGDSQSDYDTVVHPFYAYWQSFCTQKNFAWKEEYDTRQASNRWEKRAMEKENKKIRDKARKEKNELVRQLVAFIRKRDKRVQAHRKLVEEQNAEKARKAEEMRRQQKLKQAKLVEQYREQSWMTMANLEKELQEMEARYEKEFGDGSDENEMEEHELKDEEDGKDSDEAEDAELYDDLYCPACDKSFKTEKAMKNHEKSKKHREMVALLKQQLEEEEENFSRPQIDENPLDDNSEEEMEDAPKQKLSKKQKKKKQKPAQNYDDNFNVNGPGEGVKVDPEDTNLNQDSAKELEDSPQENVSVTEIIKPCDDPKSEAKSVPKPKGKKTKDMKKPVRVPAEPQTMSVLISCTTCHSEFPSRNKLFDHLKATGHARAPSSSSLNSATSSQSKKEKRKNR
Protein: Uncharacterized protein (Q385V2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Ribosomal protein S24/S35 mitochondrial conserved domain-containing protein
- Phosphatidylethanolamine-binding protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Large ribosomal subunit protein uL23m
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L9 domain-containing protein
Sequence:
MHIWRTAASNWVKRHARSNAARWRRPEPASSSAAAKTIARLLAVGGHGCWSEATALYAEALATKSVQRYGVVTPAHRHDCIALILGAMSSSVDASGSDINRGEESLTPHYGMLAERLSLDIIVPHSDVGQEEKEAASVACIAVFRALLTSGRTHAVQRFAQQLLRSRNSREHGLWALRTIMLAVTAREEGMYRQLFLHSGLLKDLEHLTGLDAFTVVMSSCDGHEKNIGPCGGRTEGNLGRDEVHRVAARWCVDVALHMHTCPWRFCLTNEKEPRRETAFNSEVTSYCCAKELPMPAFAVTMLPFEVLRSNAVGVLRCCTAAGNGSHGNEVVTFDGTASNVSGGRSGDSTSCSTTAPSLGLPALKRLQDVVSAAIEVPLSTYEPVECLYLLLQISRDSTAPDPRRVMPSTMNILWWRRHLQSCVLESVKSAVRWKSVCDFVGLSRLVTERVPHCFPLLVAHAAESPDALRTLFNEVSRQEGAAAHPVDDIPRSCVMGLLQMCGDERSAAVIDWVVEHCKDHESIAQFVLDSLGQHQKLASVVVRRLFQRSEQSSDVINALSRLLEKGTCRTLLADVCSLVPQAQQWTVALRFVSGMSAPEVGHVHTAFMAFVGNCDEQFAINMALLWSDETFTWLKADVNPPPRRVYMDDRWSDALRLVALGAERLTQRPELLGKYIRYFSKRVAVNSRLYMELEALLACSKVGGGSARNCGRSSNWNPIASTVTGGPPLETSLVGVRTGVLPKGQQWMEACAHASEVGVTRGVLEILAKRGRWEEATIVLARAEAKRRVEWAPLVIRAARLSSQWRAALSVAEKIAANGMKLHYSVVAELLACCFSADVPLEVVQLWLHRRSVGESTSSHVLFGLGPGSSLRTEQRDANDKHNVFGDASRWLGSAQAELFFVLLESSSSRSSDHQWRYALQLLKEHVLLSGGVPSARVFRSTYSILHRAERWRESLQLLGLQRSVCGSPTVKCVHLVLSTLPSTAWQYALGALQCIPPGDSGSIHRVLPLLLPVSWESALGLMIDHRVMTNTAMECVVGCEDVPLVLRLQAWRRLLPSLPVSMKHRAAPIYLRLAAGVADGDVGVEGTNGLDAMCVIERSIRGLRGDYINYASFVYHRALLHRHWCNDSLHPSGGVAAFRALSGIAEVDQQCEVSAAALEQLSNIVERLEQVCGTVSASTATHGSQHLERTVPVVNSGEILQGSAPTNARRDPETHCFSFVSSYWLSLFYLFRYCRCVISSSLFPFFLKKKDQGSGLPIFDVMRLHTVRAPIITRAAMRGYSEARSNYDGTSLPAWPAPGKKPTYPAALSELRLPQPRMRKTRTEWMYYHGHGGCPGKYGPSREIADFEYADGTPASISGRRFAFKHHQDHLLVQLIRAAATVERYDASGLLPRIPGTAEQRNWDPAIPLFLDDVDEQGRPAPLRTAGDAPGTMVSHVCSRVVDERMGTPTHTPNELANRHEGETLEANTMFATNDPSAFVSDTVKLRDDKRPYWSRRRWALTDKFLVPKSPKPKNTIKDE
Protein: Glutathione S transferase D8 (EC 1.11.1.9, EC 2.5.1.18) (IP02538p) (Q9VG92)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glutathione S-transferase D2
- Glutathione S transferase D10, isoform A
- Glutathione S-transferase D7
- Glutathione S-transferase D1
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S-transferase S1
- Myc proto-oncogene protein
- Glutathione S transferase O1
- Glutathione S transferase O3
- Pyrimidodiazepine synthase
Sequence:
MDFYYHPCSAPCRSVIMTAKALGVDLNMKLLKVMDGEQLKPEFVKLNPQHCIPTLVDDGFSIWESRAILIYLVEKYGADDSLYPSDPQKKAVVNQRLYFDMGTLFQSFVEAIYPQIRNNHPADPEAMQKVDSAFGHLDTFLEDQEYVAGDCLTIADIALLASVSTFEVVDFDIAQYPNVARWYENAKEVTPGWEENWDGVQLIKKLVQERNE
Protein: Green-emitting fluorescent protein (D1J6P8)
Organism: Cyphastrea microphthalma
Interaction partners:
Sequence:
MNVIKPDMRIKLRMEGAVNGHKFVILGDGNGKPYEGTQTIDVTVKEGGPLPFAYDILTSAFQYGNRVFTKYPDDIADYFKQSFPVGYSWERSMTYEDGGICTVSSDIKMEGNSFIYEIRFHGLNFPSDGPVMQKKTVKWEPSTEKMYVRDGVLKGDVNMTLLLEGGGHYRCDFKSTYKAKRAVQLPDYHYIDHRIEILSHDKDYNKVKLCENAAARCSMLPSQAK
Protein: Thymine-DNA glycosylase (A1L1J2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMAEAPNMADVAGQQMPAEAPAQDPVPEAPKRRKRKTRAAEAQDPVEPKKPAASKKSGKSTKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERSTDVQEVQYTFDLQLAQEDAKRTAVKEEKYDPGYEAAYGGACGENPCNGEPCGFASNGLTNSAELGGESAPSDVPNGQWMAQSFAEQIPSFNNCGTGEQEAGSHAGSHA
Protein: FruA protein (Q1D7Q3)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- Transcriptional regulator MrpC
- histidine kinase
- histidine kinase
Sequence:
MATNQAAIRVSILEGPWAAWQGLADGLRGEGVQVSSVTRDVRLFLDSLGTDPPQVAVMDVEGDSEAAVGCSVTEGINLLREARKRRLEVRMLLLSAVSTPEIISQCFDEGASGYLFRAGLGTTAVASAINSLVRGERLFPVQLLRNDFEHPPVTSPTASVLLALTQREREVLAYVAGGADNLKIAAHLQIAERTVKSHVTQLYRKLGAENRTQLALRACHLGVRPPPDL
Protein: Eukaryotic translation initiation factor 4E nuclear import factor 1 (B0QYZ7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
QKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSP
Protein: 60S ribosomal protein L20 (Q6FMK1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome M complete sequence
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein uL2
- Ribosomal protein L15
- 60S ribosomal protein L13
- 40S ribosomal protein S24
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
Sequence:
MKIVAHLREYQVIGRRLPTESVPEPKLFRMRIFAPNEVVAKSRYWYFLQKLHKVKKASGEVVSINQIHEAHPTKVKNFGVWVRYDSRSGTHNMYKEIRDVSRVAAVETLYQDMAARHRARFRSIHILKVAEIEKTADVKRQYVKQFLSKDLKFPLPHRVQKSTKTFAYKRPSTFY
Protein: RNA-binding (RRM/RBD/RNP motifs) family protein (F4JXE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSTGLDMSLDDMIAKNRKSRGGAGPARGTGSGSGPGPTRRNNPNRKSTRSAPYQSAKAPESTWGHDMFSDRSEDHRSGRSSAGIETGTKLYISNLDYGVMNEDIKELFAEVGELKRYTVHFDRSGRSKGTAEVVYSRRGDALAAVKKYNDVQLDGKPMKIEIVGTNLQTAAAPSGRPANGNSNGAPWSRGGQGRGGQQRGGGRGGGGRGGGGRGRRPGKGPAEKISAEDLDADLDKYHSGDMETN
Protein: tRNA N(3)-cytidine methyltransferase METTL2 (EC 2.1.1.-) (Methyltransferase-like protein 2) (Q8BMK1)
Organism: Mus musculus (Mouse)
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96IZ6}.
Interaction partners:
- 28S rRNA
- EF-hand calcium-binding domain-containing protein 3
- N
Sequence:
MAASFPEGVPETEDGKRPQFGHRFLSDPARVFHHNAWDNVKWSEEQAAAAERKVQENSSPLVCPEKQVDYEVNAHKYWDDFYRIHENGFFKDRHWLFTEFPELAPSHSHLTGVPLEKQRSDVCEDGPGLTAEQHKCSCASPGCETQVPPLEEPVTQKLGHLEISGEEFPGSSATYRILEVGCGVGNTVFPILQTNNNPNLFVYCCDFSATAIELLKTNSQYDPSRCYAFVHDLCDEDQSYPVPEDSLDVIVLIFVLSAIVPDKMQKAISKLSRLLKPGGVMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQGELDTLFTAAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYSKPLALRSSQHVPIPHATESSSHSGLL
Protein: Cutinase (EC 3.1.1.74) (Cutin hydrolase) (Q00298)
Organism: Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Function: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P11373}.
Interaction partners:
Sequence:
MKTSAQQLLSALLLPLSVLAAPTGSIEARACSDVTVIFARGTTETGTLGTVVGPPFLAALKSALGSSSVTMNGVDYPADVPGFLQGGDPAGSQTMATMVTSTLSSCPDTKLVISGYSQGGQLVHNAAKLLPAETTAKISSAVIFGDPDNGDPVQGVSADRTDIICHAGDNICQGGSLILLAHLTYGMDTTAAAAFVKKAAGL
Protein: Myelin and lymphocyte protein (17 kDa myelin vesicular protein) (MVP17) (NS 3) (T-lymphocyte maturation-associated protein) (Q64349)
Organism: Rattus norvegicus (Rat)
Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P21145}. Note=Found in lipid rafts. {ECO:0000250|UniProtKB:O09198}.
Interaction partners:
Sequence:
MAPAAASGGSTLPSGFSVFVTFPDLLFIFEFIFGGLVWILIASSLVPMPLVQGWVMFVSVFCFLATTSLMVMYIIGTHGGETSWITLDAAYHCVAALFYLSASVLEALATITMFDGFTYRHYHENIAAVVFAYVATLLYVIHAVFSLIRWKSS
Protein: Prominin 1 b (Prominin-like 2) (Q90WI3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, microvillus membrane {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004475}.
Interaction partners:
Sequence:
MWWKVGLVLVMFWGLTSSKDREEHRESPPRTAMLRAPVETLDFGFVPSVVYETHAYYEPGPMGILFHMVHAFLYVVQPNPFPKDLIVKMVQQNMGGIKGDDYKKPENVVLLLQTIYYELGFIVLSVLGVFFVLLMPIVGLCFCVCRCCENCGGEMHQRQKKNGDCLRGFYMATLIATSVFLAVGVTVAYVANQNITSQIKSTRRLVSTNIRDLKAFANYTPAQIDYLTAQYTTAKNKVLSDLDNIGTLLGGQIHNKLESEVVPALDHALRMTAAMRETKESLESVSTSLETLQEGTGRLQVSLQSERASLSNTLNDWACSNEDVTHTCNSIRGTLNQLALSANFNGLPDVEAPLANLDAVLKTDLSNIVQKGYSSFNDTPQLVREQTKGIVSALPKVKGLLDKSGAEIIGFTKMFPVEPALQNFSKFLTDSQKNIEAYYPQIDQLDFYRWIGCVLICCLVVLVLAFNFLGLLCGSCGYDKNSTPTTRGCLSNTGGNLLMASVGFSFIFSWVLMGVVVTTFIVGGNIEKLVCEPLANRQIFKIIDTPYMVHPTKKNFLPGMLFQDPNIDLTIGSMYRDCYENNGLYSALQLETKFNFNKFLNATVFNPEIGNIFNNVNVDLQGMLLLEQEGKDNLIDFANTGIGDIDYQAYLTEVNKGVTVVDLLSYANELDAQADNLPRGALENALKGHASSIRQIHKDQVVPMEQAMSNLNQSIRQLEKTSRELPVKVTNVLNAIEAAEYLISNNASHVVKQESDKFIKKIIGYFSQYTEWVKHSLAMEVAQCKPISNIVDSAEIVACSFIVDSVNTFWFGLGGCCVLLIPSIIMSVKLAKFYRRMDTEDVFDDGSENWS
Protein: E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.36) (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1) (P90495)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Membrane-bound E3 ubiquitin ligase expressed during late stages of lytic replication to mediate polyubiquitination of various host membrane proteins related to the immune response. Promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, DC-SIGN and DC-SIGNR, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.
Subcellular location: Host cell membrane {ECO:0000269|PubMed:10799607}; Multi-pass membrane protein {ECO:0000269|PubMed:10799607}. Host endoplasmic reticulum {ECO:0000269|PubMed:10799607}. Note=Probably exerts its effects at the plasma membrane during viral infection.
Interaction partners:
Sequence:
MEDEDVPVCWICNEELGNERFRACGCTGELENVHRSCLSTWLTISRNTACQICGVVYNTRVVWRPLREMTLLPRLTYQEGLELIVFIFIMTLGAAGLAAATWVWLYIVGGHDPEIDHVAAAAYYVFFVFYQLFVVFGLGAFFHMMRHVGRAYAAVNTRVEVFPYRPRPTSPECAVEEIELQEILPRGDNQDEEGPAGAAPGDQNGPAGAAPGDQDGPADGAPVHRDSEESVDEAAGYKEAGEPTHNDGRDDNVEPTAVGCDCNNLGAERYRATYCGGYVGAQSGDGAYSVSCHNKAGPSSLVDILPQGLPGGGYGSMGVIRKRSAVSSALMFH
Protein: Protein tyrosine phosphatase Meg2, isoform F (EC 3.1.3.-, EC 3.1.3.48) (Q59E68)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDEREPDSE
Protein: Cytoskeleton bundling-enhancing antitoxin CbeA (Antitoxin CbeA) (Antitoxin YeeU) (P76364)
Organism: Escherichia coli (strain K12)
Function: Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes. The intergenic region was not found to be necessary in another study. Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape. Also counteracts the effect of non-cognate toxins YfkI and YpjF.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Cytoskeleton-binding toxin CbtA
- Cell shape-determining protein MreB
- Cell division protein FtsZ
- Toxin GhoT
- Toxin YpjF
- Endoribonuclease antitoxin GhoS
- Inner membrane protein YgfX
- Uncharacterized protein YeeT
- Toxin YkfI
Sequence:
MSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN
Protein: Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13] (Q9ULZ1)
Organism: Homo sapiens (Human)
Function: Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9TUI9}. Secreted, extracellular space {ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:38428423}. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. {ECO:0000250|UniProtKB:Q9TUI9}.
Interaction partners:
- Apelin receptor
- Apelin receptor early endogenous ligand
- Kininogen-1
- Angiotensin-converting enzyme 2
- Angiotensinogen
- Neuropeptide B
- Pro-neuropeptide Y
- Type-1 angiotensin II receptor
- Retinoic acid receptor responder protein 2
- Galanin peptides
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
Protein: Vezatin (Q3ZK22)
Organism: Mus musculus (Mouse)
Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16199027}; Multi-pass membrane protein {ECO:0000305}. Cell projection, stereocilium membrane {ECO:0000269|PubMed:17567809}. Cell junction, adherens junction {ECO:0000269|PubMed:16199027}. Nucleus {ECO:0000269|PubMed:16199027}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:17379651}.
Interaction partners:
- Usherin
- Whirlin
- PDZ domain-containing protein 7
- Unconventional myosin-VIIa
- Adhesion G-protein coupled receptor V1
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS17
Sequence:
MTPEFDEEVVFENSPLYQYLQDLGHTDFEICSSSSPKPEKCLTTEGPQPPPTRVLQRQGILLKLTETIKSWTFSSQHSKKDDLLHKLDTGFRLDSLHTILQQEVLLQEDVELLELLDASILSAGQPQQESGHLPTLCSLATPNTWDVSLLFAFISLLIMFPTCWIVSSWLVWGIILFLYLIIRVLKLWRTAKLQMTLKKYRVRLEDMAANSRAFTNLVRKSLRLIQETEVISRGFTLVSAACSFNKAAQHPGQHLIGLRKAVYRTVRANFQAARLATLYMLKNYPLNSESDNVTNYICVVPFKELGLGLSEDQISEEEARNLTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTANSPSGPLLTAALLPHHILCDVTQGLPHAHSACLDELKRSYEFFRYFETQHQSVPQRLSKTPQKSRELSNVHTAVRSLQLHLKALLNEVIILEDELEKLVCTKETQELLSEAYPILEQKLKLIEPHVQASNSCWEEAISQVDKLLRRNTDKKGKPGVACENPHCTAEPLVRPALHIEDRDPIPEEQELEAYVDDIDIESEFRKDDFYHLSQEDRERQKREQEESRRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLTSLSPVDPVESVSNSEPPMNSDTEKVNSNATEEETSKPCAGDKEDSRTEYVCDSPTEGPSKDTSADTGLLLPGAEETMCHQHESEAKSPQAAAAGATAPPTPRDTLQLSIKQRLARLQLPPEFTFSAGLAAEVAARSLSFTTMQEQTFGDEEEEQLVEGGENEVEEK
Protein: Alliin lyase 2 (Alliinase-2) (EC 4.4.1.4) (Cysteine sulphoxide lyase 2) (Q41233)
Organism: Allium sativum (Garlic)
Function: Able to cleave the C-S bond of sulfoxide derivatives of Cys to produce allicin, thus giving rise to all sulfur compounds which are responsible for most of the properties of garlic, such as the specific smell and flavor as well as the health benefits like blood lipid or blood pressure lowering.
Subcellular location: Vacuole {ECO:0000305|PubMed:7979352}.
Interaction partners:
Sequence:
MICLVILTCIIMSNSFVNNNNMVQAKMTWTMKAAEEAEAVANINCSEHGRAFLDGIISEGSPKCECNTCYTGPDCSEKIQGCSADVASGDGLFLEEYWKQHKEASAVLVSPWHRMSYFFNPVSNFISFELEKTIKELHEVVGNAAAKDRYIVFGVGVTQLIHGLVISLSPNMTATPDAPESKVVAHAPFYPVFREQTKYFDKKGYVWAGNAANYVNVSNPEQYIEMVTSPNNPEGLLRHAVIKGCKSIYDMVYYWPHYTPIKYKADEDILLFTMSKFTGHSGSRFGWALIKDESVYNNLLNYMTKNTEGTPRETQLRSLKVLKEIVAMVKTQKGTMRDLNTFGFKKLRERWVNITALLDQSDRFSYQELPQSEYCNYFRRMRPPSPSYAWVNCEWEEDKDCYQTFQNGRINTQSGVGFEASSRYVRLSLIKTQDDFDQLMYYLKDMVKAKRKTPLIKQLFTDETETASRRPFI
Protein: Interferon regulatory factor 5 (IRF-5) (Q13568)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Nucleus {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}.
Interaction partners:
- TNF receptor-associated factor 6
- Myeloid differentiation primary response protein MyD88
- C-C motif chemokine 4
- C-C motif chemokine ligand 4 like 2.
- Signal transducer and activator of transcription 1-alpha/beta
- Interleukin-1 receptor-associated kinase 1
- Signal transducer and activator of transcription 4
- Non-receptor tyrosine-protein kinase TYK2
- Tumor necrosis factor alpha-induced protein 3
- Tyrosine-protein phosphatase non-receptor type 22
Sequence:
MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ
Protein: Pre-mRNA processing factor 31 (E7EN72)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLP