wanglab/gogpt-training-data huggingface dataset:
Protein: Protein lin-7 homolog (A5PEX5)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
Interaction partners:
- Protein lin-2
- Receptor tyrosine-protein kinase let-23
- Protein lin-10
- PH domain-containing protein
- FeS cluster biogenesis domain-containing protein
- L51_S25_CI-B8 domain-containing protein
- Protein lin-3
- MAGUK p55 subfamily member 5
- Adenylyltransferase and sulfurtransferase MOCS3
- E3 ubiquitin-protein ligase CBL
Sequence:
MDNPDGPNLERDVQRILELMEHVQKTGEVNNAKLASLQQVLQSEFFGAVREVYETVYESIDADTTPEIKAAATAKATVAAFAAAEGHAHPRIVELPKTDQGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLIAVNGVNVEAECHEKAVDLLKSAVGSVKLVIRYMPKLLDEMERRFERQRIRSTQQSPTLPTPSSSTNPRR
Protein: Zinc finger and SCAN domain containing 26 (Zinc finger protein 187, isoform CRA_a) (A0A024RCN4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
Interaction partners:
Sequence:
MATALVSAHSLAPLNLKKEGLRVVREDHYSTWEQGFKLQGNSKGLGQEPLCKQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVLEDLQLDLGETGQQVDPDQPKKQKILVEEMAPLKGVQEQQVRHECEVTKPEKEKGEETRIENGKLIVVTDSCGRVESSGKISEPMEAHNEGSNLERHQAKPKEKIEYKCSEREQRFIQHLDLIEHASTHTGKKLCESDVCQSSSLTGHKKVLSREKGHQCHECGKAFQRSSHLVRHQKIHLGEKPYQCNECGKVFSQNAGLLEHLRIHTGEKPYLCIHCGKNFRRSSHLNRHQRIHSQEEPCECKECGKTFSQALLLTHHQRIHSHSKSHQCNECGKAFSLTSDLIRHHRIHTGEKPFKCNICQKAFRLNSHLAQHVRIHNEEKPYQCSECGEAFRQRSGLFQHQRYHHKDKLA
Protein: Probable protein adenylyltransferase Fic (EC 2.7.7.108) (Cell filamentation protein Fic) (P20605)
Organism: Escherichia coli (strain K12)
Function: Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division.
Interaction partners:
- Uncharacterized protein YhfG
- Serine/threonine kinase YeaG
- Protein YjdN
- Universal stress protein B
- Trehalose-6-phosphate phosphatase
- Uncharacterized protein YodD
- Uncharacterized protein YgaM
- Potassium binding protein Kbp
Sequence:
MSDKFGEGRDPYLYPGLDIMRNRLNIRQQQRLEQAAYEMTALRAATIELGPLVRGLPHLRTIHRQLYQDIFDWAGQLREVDIYQGDTPFCHFAYIEKEGNALMQDLEEEGYLVGLEKAKFVERLAHYYCEINVLHPFRVGSGLAQRIFFEQLAIHAGYQLSWQGIEKEAWNQANQSGAMGDLTALQMIFSKVVSEAGESE
Protein: SHC SH2 domain-binding protein 1 (Protein expressed in activated lymphocytes) (mPAL) (SHC-binding protein) (Q9Z179)
Organism: Mus musculus (Mouse)
Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
Subcellular location: Midbody {ECO:0000250|UniProtKB:Q8NEM2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NEM2}. Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis. {ECO:0000250|UniProtKB:Q8NEM2}.
Interaction partners:
- Rac GTPase-activating protein 1
- Kinesin-like protein KIF23
- Baculoviral IAP repeat-containing protein 5
- Cyclin-A2
- Lymphokine-activated killer T-cell-originated protein kinase
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Non-SMC condensin I complex, subunit G
- Condensin-2 complex subunit G2
- Kinesin-like protein KIF20A
- Borealin
Sequence:
MADDLRAGGVLEPIAMVPPRPDLAAEKEPASWKEGLFLDADPCSDQGYHANPGATVKTLIPEGKTPFPRIIQTNELLFYERFRAYQDYILADCKASEVKEFTVSFLEKVLEPSGWWAVWHTNVFEVLVEVTNVDFPSLKAVVRLAEPCIYESKLSTFTLANVKELLDLKEFHLPLQELWVVSDDSHEFHQMALAIEHVRFFYKHIWRSWDEEEEDEYDYFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQGKGTRQNGQKVIHVVSSTMKTGLLRSLFKDRFCEESCKEETEIKFHSDLLSGINACYDGDTVIICPGHYVVHGTCSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGMDVKISGIKFIQHDSVEGILIIHHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNGIHHCKEGILIKDFLDEHYDIPKISMINNVIHNNEGYGVVLVKPTIFCDLQENTQDEINDNMVQKNKEADVTEGLDLEEMLQCVASKMEPYATADFNEQAKGNCEIINELLAISMQKGRMKKRLSELGITQADDNIMSQEMFIEIMGNQFKWNGKGSFGTFLY
Protein: Protein SUPPRESSOR OF NPR1-1 CONSTITUTIVE 4 [Includes: Glycerophosphodiester phosphodiesterase protein kinase domain-containing GDPDL2 (EC 3.1.4.46) (Glycerophosphodiester phosphodiesterase-like 2) (ATGDPDL2); LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 2.6 (EC 2.7.11.1) (Probable receptor-like serine/threonine-protein kinase LRK10L-2.6)] (D7SFH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical receptor-like kinase involved in disease resistance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20508139}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- SUPPRESSOR OF ABI3-5
- DNA-damage-repair/toleration protein 111
- Negative regulator of systemic acquired resistance SNI1
- Uncharacterized protein
- Uncharacterized protein
- Receptor-like protein 51
- Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- Protein ALP1-like
Sequence:
MNSQQSTRTKQMLQQSSTHLLCGVVLLQLFAAQVDAQRSTSPWQTLSGDAPLVIARGGFSGLFPDSSLAAYQFAMVVSVADVVLWCDVQLTKDGHGICFPDLNLANASNSEEVYPNRQKSYPVNGVTTKGWFPIDFSLTELQKVLFSLIRGILSRSGKFDENGYSISTVQNVATQMKPALFWLNVQHDEFYEQHNLSMSSFLLSTSRTVSIDFISSPEVNFFRKIAGGFGNNGPSFVFQFMGKEDFEPTTNRTYGSILSNLSFVKTFASGILVPKSYILPLDDKQYLLPHTSLVQDAHKAGLKLYASGFANDVDIAYNYSWDPVSEYLSFVDNGNFSVDGMLSDFPLTASASVDCFSHIGRNATKQVDFLVISKNGASGEYPGCTKLAYEKAIKDGSDVIDCPVQMSSDGIPFCSSSIDLVNSTTVGQTHLRNRSIIVPEISSVAGIFTFSLTWHEIQSLTPAISNPFRENGMSRNPNERNSGNLISLYEFLNLAKNSTSLSGILISLENVVYLREKKGLDVVKVVLNRLTETGYIVGTLKVMIQSTTRLVLVDFKNQSTYKTVYKIKETIGNITDSAIEDIKKFANAVVINKASVFPNSDSFLTGQTTNVLERLQKFQLPVYVELFQNEFVSQPFDFFADETVEINAYIFGAGINGTITEFPYTAARYKRNRCLGREEVPPYMLPVNPGGVLTLISTSSLPPAQDPNPIFTHDDVTEPPLPPVIAKSPTSTLGTPSTIAKPLRNFLKVIRIVSWSVAGVVLFLVLLTLVFCFHRKRETRLRQQKLKALIPLEHYTYAQVKRITKSFAEVVGRGGFGIVYKGTLSDGRVVAVKVLKDTKGNGEDFINEVATMSRTSHLNIVSLLGFCSEGSKRAIIYEFLENGSLDKFILGKTSVNMDWTALYRIALGVAHGLEYLHHSCKTRIVHFDIKPQNVLLDDSFCPKVSDFGLAKLCEKKESILSMLDTRGTIGYIAPEMISRVYGNVSHKSDVYSYGMLVLEIIGARNKEKANQACASNTSSMYFPEWVYRDLESCKSGRHIEDGINSEEDELAKKMTLVGLWCIQPSPVDRPAMNRVVEMMEGSLEALEVPPRPVLQQIPISNLHESSILSEDVSVYTEG
Protein: Sialic acid binding Ig-like lectin H (Siglech protein) (B7ZMQ5)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MLLSRLLPLLWVLKWASGNCFILPREVIGTYPSLTLELQSVTVQEGLCVLVPCHLIEYPMNRWSDAAFGYWFHEGENTHPDSLVATNKPYQLVQKEMQSRFHFSGDCSLDIRDAQKGDNGSYFFRLEKGGKTWNFCEERISVHVTDNSQNSTAHVSGRVGPGKPRPLADVVQVAMGEAAIKFLLLGICFFFLSKRSHTKRVERPATHMDQAHAVMD
Protein: ATP-binding cassette, sub-family C member 8 (A0A1B0GT25)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
XADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRADK
Protein: Syntaxin-1B (F5HN09)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
Sequence:
MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDERTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDLFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSICGTLGL
Protein: Protein LOL2 (Protein LSD ONE LIKE 2) (AtLOL2) (Putative zinc finger LOL2) (O65426)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative zinc finger that may be involved in programmed cell death and defense response.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Auxin-responsive protein IAA10
- Probable transcription factor At3g04930
- Metacaspase-1
- Transcription factor
- Transcription factor STKL1
Sequence:
MEEIQQQTQKEEQKHREEEEEEEEGPPPGWESAVLPPPIVTITAAVNPNPTTVEIPEKAQMVCGSCRRLLSYLRGSKHVKCSSCQTVNLVLEANQVGQVNCNNCKLLLMYPYGAPAVRCSSCNSVTDISENNKRPPWSEQQGPLKSLSSLRRAEN
Protein: Uncharacterized protein (A0A1D8PS89)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Fgr39p
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MTNKGKLSKTISKYFANTIGFSCRITPPPNTSLELDYLLHNFHKLAPLDNFQTISNSNHGFFINAIYSPCRDESWFKLIKPDENHLFEEIDSKFTNTIKNDFINKLTSLVAIPRYSYIENNKDFQNYKLQIRFDHNIQRSIANYKGKYNLTTSTVDDPFISIINNDNANGTNNDDDDEVSIDYEKLRVNLRHNFQKFHKFDKIEIITNPNRLINRLK
Protein: Cecropin-P4 (Q5H7N4)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Has antibacterial activity against several Gram-positive and Gram-negative bacteria. Is weakly active against yeasts. Acts by a nonpore mechanism.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MFLMYLLVQTTESSWLSKTYKKLENSAKKRISEGVAIAILGGLRHRRSVAHQEEASLHVKTDELPSPDTVREQL
Protein: Calcium-binding site protein (O22947)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein DETOXIFICATION 3
- Protein DETOXIFICATION 4
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- Cytosolic sulfotransferase 12
- Paraxanthine methyltransferase 2
- Protein DETOXIFICATION 1
- Protein HYPER-SENSITIVITY-RELATED 4
- Cytochrome P450, family 81, subfamily D, polypeptide 8
- Paraxanthine methyltransferase 1
Sequence:
MKSEGRHQGIVRTGMIHPRGFNPRPTSNRLDSPPAFGDFTKVPSKTTNHSNTTGESERSKYSHCHVSPAIKSGHKSKGRRKLQPTSWWSEDKLDRLIGSDSSSAKDILDTLCGEDHDEH
Protein: Metallothionein-like protein 4B (MT-4B) (EC protein homolog 2) (Q42377)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn). Plays a role in storing and distributing Zn ion in seed.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22014117}. Nucleus {ECO:0000269|PubMed:22014117}. Cell membrane {ECO:0000269|PubMed:22014117}.
Interaction partners:
- Metallothionein-like protein 1A
- Metallothionein-like protein 1C
- Metallothionein-like protein 2B
- Metallothionein-like protein 2A
- Serine carboxypeptidase-like 17
Sequence:
MADTGKGSASASCNDRCGCPSPCPGGESCRCKMMSEASGGDQEHNTCPCGEHCGCNPCNCPKTQTQTSAKGCTCGEGCTCATCAA
Protein: Glutamate--LysW ligase ArgX (EC 6.3.2.-) (Q970U6)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Function: Catalyzes the ATP-dependent formation of a covalent bond between the amino group of glutamate and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
Interaction partners:
- Alpha-aminoadipate/glutamate carrier protein LysW
- [LysW]-aminoadipate/[LysW]-glutamate kinase
- Aspartate aminotransferase
- Glutamate dehydrogenase
- Argininosuccinate lyase
- Carbamoyl phosphate synthase small chain
- Argininosuccinate synthase
- Carbamoyl phosphate synthase large chain
Sequence:
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRALYSSAVLEAAGVHTINSSDVINVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSALKAHIVQEYIQYKGRDIRCIAIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILEHPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK
Protein: Co-chaperone protein daf-41 (Abnormal dauer formation protein daf-41) (p23/cytosolic prostaglandin E synthase 3 homolog) (Q23280)
Organism: Caenorhabditis elegans
Function: Co-chaperone for hsp90/daf-21. Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures.
Interaction partners:
- Heat shock protein 90
- Serine/threonine-protein phosphatase 5
- Prostaglandin E synthase 2
- Stress-induced-phosphoprotein 1
- peptidylprolyl isomerase
- Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein
- Histidine kinase/HSP90-like ATPase domain-containing protein
- TPR_REGION domain-containing protein
- Endoplasmin homolog
- Peptidyl-prolyl cis-trans isomerase 9
Sequence:
MAKQPTVLWAQRESLVYLTIEVDEAKIEELKGEGNKLHFQGSSKTDKYEATLEFFDEIDPASVKHTGSSTRVVEITVQKKTPAWWPRLLQNKGKVHWLKVDFGKWKDEDEDDEAEDAGAGIGGGMANGFDLNQYMSQMGGAGGADFGGLEDDEEDDDMPDLEDNEEEEGKNGTRA
Protein: Growth/differentiation factor 3 (GDF-3) (Q9NR23)
Organism: Homo sapiens (Human)
Function: Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto.
Subcellular location: Secreted {ECO:0000269|PubMed:19864492, ECO:0000269|PubMed:21805089}. Cytoplasm {ECO:0000269|PubMed:19864492, ECO:0000269|PubMed:21805089}. Note=Mainly accumulated in the cytoplasm. {ECO:0000269|PubMed:21805089}.
Interaction partners:
- Activin receptor type-1C
- Protein Cripto
- Activin receptor type-2B
- Activin receptor type-2A
- Homeobox protein NANOG
- ATP-dependent RNA helicase DDX1
- Developmental pluripotency-associated protein 4
- POU domain, class 5, transcription factor 1
- Visual system homeobox 2
- Nodal homolog
Sequence:
MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG
Protein: LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) (O54785)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P53671}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P53671}.; SUBCELLULAR LOCATION: [Isoform LIMK2a]: Cytoplasm {ECO:0000250|UniProtKB:P53671}. Nucleus {ECO:0000250|UniProtKB:P53671}.; SUBCELLULAR LOCATION: [Isoform LIMK2b]: Cytoplasm {ECO:0000250|UniProtKB:P53671}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P53671}. Nucleus {ECO:0000250|UniProtKB:P53671}.
Interaction partners:
- Cofilin-1
- Cofilin-2
- Rho-associated protein kinase 1
- Rho-associated protein kinase 2
- LIM domain kinase 1
- Serine/threonine-protein kinase PAK 4
- Serine/threonine-protein kinase PAK 1
- Serine/threonine-protein kinase PAK 2
- Serine/threonine-protein kinase PAK 3
- Serine/threonine-protein kinase PAK 5
Sequence:
MAALAGDEAWRCRGCGTYVPLSQRLYRTANEAWHGSCFRCSECQESLTNWYYEKDGKLYCHKDYWAKFGEFCHGCSLLMTGPAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQDQLPYSVTLISMPATTECRRGFSVTVESASSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIKQTSQTLQLLIEHDPVPQRLDQLRLDARLPPHMQSTGHTLMLSTLDTKENQEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEALSLFLGELAIPLPAELEDLDHTVSMEYGLTRDSPP
Protein: Meiotic recombination protein rec-8 (Cohesin rec-8) (Q9XUB3)
Organism: Caenorhabditis elegans
Function: Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division.
Subcellular location: Chromosome {ECO:0000269|PubMed:11390355, ECO:0000269|PubMed:11940606, ECO:0000269|PubMed:12827206, ECO:0000269|PubMed:14499625, ECO:0000269|PubMed:21856158, ECO:0000269|PubMed:23401519, ECO:0000269|PubMed:25171895}. Nucleus {ECO:0000269|PubMed:11390355, ECO:0000269|PubMed:21856158, ECO:0000269|PubMed:25171895}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23401519}. Note=Colocalizes with smc-1 along synapsed chromosomes during meiotic pachytene and diakinesis (PubMed:12827206). Loaded onto chromosomes upon entry into meiosis (PubMed:21856158). Localizes to chromosomes until meiotic anaphase II and to microtubules throughout meiotic divisions (PubMed:23401519). {ECO:0000269|PubMed:12827206, ECO:0000269|PubMed:21856158, ECO:0000269|PubMed:23401519}.
Interaction partners:
- Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein
- HORMA domain-containing protein
- Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein
- Aurora/IPL1-related protein kinase 2
- Structural maintenance of chromosomes protein 3
- Cohesin subunit scc-3
- HORMA domain-containing protein
- HORMA domain-containing protein
- Long arms of the bivalent protein 1
- Rad21_Rec8 domain-containing protein
Sequence:
MVVSAEVIRKDAVFHVAWILGTGDSKKLSRREILDQNLPELCHSIIEMVPERHRGSATKTGLYLLSLLTYGTVLIHQVQVDFLKRDVEKLKELMKKKSFILLMAERFDRNQELQRKEDKFARLRSKPIMCVEELDRVDLAHLQAIGDELGINGNPGDFIMMDALPNMNQWIDNNSELNAIYGCVEPYLREKEITMHSTFVEGNGSNEHNKERRNDAVIADFSQLLFPEIPEITLGEKFPIDVDSRKRSAILQEEQEEALQLPKEASEIVQEEPTKFVSIALLPSETVEQPAPQEPIQEPIQPIIEEPAPQLELPQPELPPQLDAIDLVTIPASQQDMVVEYLQLINDLPDDENSRLPPLPKDLELFEDVILPPPAKKSKVEEEEDALERARRRPSSRPVTPINQTDLTDLHSTVRPEDPSFAIDSQIHDVLPQRKKSKRNLPIIHSDDLEIDEAVQKVLQADYSSLVRKKEDVIAKIPPKTDAVAVLMNLPEPVFSIGYRLPPEVRDMFKACYNQAVGSPVSDDEEDEDEEEEEEYKYAKVCLLSPNRIVEDTLLLEEQPRQPEEFPSTDNINPPRQLQENPVFENLEYEAPPHPIRTARTPTPIKDLKYSVISLFPTPEKRRETSIIAELNLDPIPVEEIDPLLTMRTEEELENVRRRQKSSLGVQFMRTDDLEEDTRRNRLFEDEERTRDAREDELFFYSSGSLLPNNRLNIHKELLNEAEARYPEWVNFNEFTADHDRKKAATAFEGLLLSLKNMKVEAKQEDPYFPILVRHISHEEM
Protein: Core gene UL27 family protein (Envelope glycoprotein gB) (Glycoprotein B) (ORF8) (Q77UU3)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MTPRSRLATLGTVILLVCFCAGAAHSRGDTFQTSSSPTPPGSSSKAPTKPGEEASGPKSVDFYQFRVCSASITGELFRFNLEQTCPDTKDKYHQEGILLVYKKNIVPHIFKVRRYRKIATSVTVYRGLTESAITNKYELPRPVPLYEISHMDSTYQCFSSMKVNVNGVENTFTDRDDVNTTVFLQPVEGLTDNIQRYFSQPVIYAEPGWFPGIYRVRTTVNCEIVDMIARSAEPYNYFVTSLGDTVEVSPFCYNESSCSTTPSNKNGLSVQVVLNHTVVTYSDRGTSPTPQNRIFVETGAYTLSWASESKTTAVCPLALWKTFPRSIQTTHEDSFHFVANEITATFTAPLTPVANFTDTYSCLTSDINTTLNASKAKLASTHVPNGTVQYFHTTGGLYLVWQPMSAINLTHAQGDSGNPTSSPPPSASPMTTSASRRKRRSASTAAAGGGGSTDNLSYTQLQFAYDKLRDGINQVLEELSRAWCREQVRDNLMWYELSKINPTSVMTAIYGRPVSAKFVGDAISVTECINVDQSSVNIHKSLRTNSKDVCYARPLVTFKFLNSSNLFTGQLGARNEIILTNNQVETCKDTCEHYFITRNETLVYKDYAYLRTINTTDISTLNTFIALNLSFIQNIDFKAIELYSSAEKRLASSVFDLETMFREYNYYTHRLAGLREDLDNTIDMNKERFVRDLSEIVADLGGIGKTVVNVASSVVTLCGSLVTGFINFIKHPLGGMLMIIIVIAIILIIFMLSRRTNTIAQAPVKMIYPDVDRRAPPSGGAPTREEIKNILLGMHQLQQEERQKADDLKKSTPSVFQRTANGLRQRLRGYKPLTQSLDISPETGE
Protein: E3 SUMO-protein ligase pli1 (EC 2.3.2.-) (E3 SUMO-protein transferase plil) (O94451)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:15359282}.
Interaction partners:
- SUMO-conjugating enzyme ubc9
- Ubiquitin-like protein pmt3/smt3
- E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8
- E3 SUMO-protein ligase nse2
- DNA damage tolerance protein rad31
- Ubiquitin-like-specific protease 1
- DNA repair protein rad60
- Proliferating cell nuclear antigen
- Ubiquitin-like-specific protease 2
- Nucleoporin nup132
Sequence:
MNQANFLQELPNVLKRLETGLIIPQLKDILRVFGLRLSGTKAELITRIKQLIERIAIENNTTSWEALKKAIDGDVTSAVCILKYNTYQIYSAAAPIAPPSSASGNRSYSRPFAPVVHSRIRFRKSPFYDILEQFNAPFVVPACVGTRNTISFSFHVTPPALSKLLNDPKQYRVYLFSTPSETIGFGNCLMEFPTPQMELRINNQVAHANYRRLKGKPGTTNPADITDLVSKYAGPPGNNVVIYYMNSTKSYSVVVCFVKVYTIENLVDQIKSRKAESKEKIIERIKNDNQDADIIATSTDISLKCPLSFSRISLPVRSVFCKHIQCFDASAFLEMNKQTPSWMCPVCASHIQFSDLIIDGFMQHILESTPSNSETITVDPEGNWKLNTFDEPVESSEDEFVPKEKVIELSDGEGISTMANKSNDQPTRRASTHNSGPPAKRKRESLVIDLTISDDDENVATSTTESPSNATKENSLSRNVQSPNIDTAISNRSTNVRHGHPGFKDYTVENSPASRERSTSESAQSSVHMGYAGEGGLLSGALRAPSQQNNNNSNTQHSINLHTIVPSPYEPPLSVTPSTAITNLSIPESNRTNSSASSKSFTMNDLILPPLHLKNTTQTNNAHEDAQSSNLSQNHSLFYERIPQRPSYRIEKQNKGIYEDENEQSISAMPIPRAHPQLPKNLLSQTAGPLWDEQQDAQVDWNSELQSNNSYHNSGFEGTGNTFQSID
Protein: Probable endopeptidase Rv2190c (EC 3.4.-.-) (P9WHU3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Peptidase M23 domain-containing protein
- DUF4157 domain-containing protein
- Diacylglycerol acyltransferase/mycolyltransferase Ag85B
- Ribosomal RNA small subunit methyltransferase A
- Probable conserved Mce associated membrane protein
- Resuscitation-promoting factor RpfB
- GDP-mannose-dependent alpha-
Sequence:
MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY
Protein: Carbonic anhydrase (EC 4.2.1.1) (F1Q816)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Sodium/hydrogen exchanger
- Ammonium transporter Rh type C-like 2
- Rh family, C glycoprotein a
- Sodium/hydrogen exchanger
- Solute carrier family 26 member 6
- Large ribosomal subunit protein uL6
Sequence:
MIAFLISFLAALLCESVHSDNSAVAWCYDNPSCNFTTWPELAPHYCNGSSQSPINIVTAQILENSNLTQFNFTGFDANTTFISMANSGTSVVVTLDEQIMSVQGGDLPGLYVSKHFHLHWGNSSSIPGSEHTVDGKQYAMELHIVNVHSKYNGSLSAALAANDSSALAVLGFFIEGTNEASKAKGWGVLTSFLRNITYSGNATVDIMNQTSMNSLLEGVNKTKYYRYRGSLTTPSCNEAVIWTVFKEPIKVNNNLINLFSTTVFAKNASAPVLNVNNFRGVQPLNGRVVTSQVEQTASPTAPSSAATSISSLSLLLLLTSLCCL
Protein: RNA binding motif protein 17 (Q5W011)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPP