wanglab/gogpt-training-data huggingface dataset:
Protein: Protein nipi-3 (No induction of peptide after drechmeria infection protein 3) (Tribbles homolog nipi-3) (G5EED4)
Organism: Caenorhabditis elegans
Function: Adapter protein that regulates different signaling pathways (By similarity). Required for larval development and viability. Involved in negatively modulating pmk-1 p38/MAPK signaling. Involved in innate immunity, acting either in a manner dependent upon, or independent of, the pmk-1 or pmk-3 p38/MAPK pathways. Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa, acting by negatively modulating expression of cebp-1, and regulating the pmk-1 p38/MAPK pathway, leading to activation of transcription factor skn-1. Required to prevent P.aeruginosa toxin ToxA-mediated lethality, probably acting via modulating the effects of translational inhibition caused by the toxin. By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection.
Subcellular location: Nucleus {ECO:0000269|PubMed:27927209}.
Interaction partners:
- Protein kinase C-like 1
- Serine/threonine-protein kinase akt-2
- Serine/threonine-protein kinase akt-1
- Guanine nucleotide-binding protein alpha-12 subunit
- Signal transducer and activator of transcription b
- Small ribosomal subunit protein RACK1
- Neuropeptide-like protein 29
- Mitogen-activated protein kinase pmk-1
- Fibrinogen C-terminal domain-containing protein
Sequence:
MARTKCKTKTVANPRTGVRKTAKDLSEPVRQDAVSRRRPTTLPFVGNTSSRPRVFYDVLAKKNVVFPNVKAEYHYRVRNAPKIDPKNFGTTLPICYSSIGPAKTLELRPLGRLPPHIIKALNDHYVQLTRGSMVPAADLYNNGDHPAEQRIPTMLNENEYLRLIQELEEEEKSKQFSATSSSAPHVNPYSAQHLVNGEIIGIFVIYGTGLVTRAVCSQTREMFTAHVLPEWKASKVIDVIRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILMNPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHSRKVILQNFKPRSFYLKKDAHNKWVVRPCFLQDMSCEEDQSEAQFTRRSVCVPFMAPEMLTAESRTHHSYSTELWGLGVLLYILLTGKYPFHENSMPLLFRTIKFKQHRWPFNFISSKSRNIVNMLLKKAPATRMNLEDLWNQVNGDFPEIRCRSNIILKKQDMIVKMDLFEMYYNTYKDRLLPKNVLPMYEEMKACRNDSTILTEMAKRDFRSIQEQMKRRIETKPTEYQTLVMQVRLQQINQLFFEKEVSQAQKQHRAPRLVQLKCSDISKELLLPGDIYPISEHYHPSQQPVDKVVYKLLSDANSLAFPTVMKGTVPKSYPPPVFKGLDISPS
Protein: Mating type protein MAT1-2-1 (Q4WWK2)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Cytoskeleton assembly control protein Sla2, putative
- Mating locus protein, putative
- 40S ribosomal protein S4
Sequence:
MATVPIAMKPAAESTDTLTELLWQDALRHLESTNNEVLLPINVTDMIGQDNVDKIKTRLGALIGAPVVAFVDETIKALRVMRTPAFSGTAVSVASHGEAVKTNKVTVTESFAPRGKPVGPLKAPKVPRPPNAFILYRQHHHPKIKEAYPDYSNNDISVMLGKQWKDENEEIKTQFRNLAEELKKKHAEDHPDYHYTPRKPSERKRRTSSRQFSKNTKPAALRDTPASMNISSDVSTPAMLEGMPVGEIDFNAAFEDVPGINAIMTSNSILKNQQYHFEPNAFDLMNQVQNDYNKTALYQQLSLPEGQIGENFEFTDFISDCF
Protein: Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) (Q9ULJ8)
Organism: Homo sapiens (Human)
Function: Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Nexilin
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Ribosomal protein S6 kinase beta-2
Sequence:
MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAEGAGEQ
Protein: Integrin subunit alpha 8 (A0A8I6GID8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
Sequence:
MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGKNHCSSTGSFSEELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACTAFTQCFSQHGFVHSLSVCPLALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA
Protein: Stigma-specific STIG1-like protein 4 (Protein KERBEROS) (Q9C6P6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endosperm-specific cysteine-rich protein that acts downstream of BHLH95/ZOU to modify the interface between embryo and endosperm and mediate the separation of these two tissues during seed development. Necessary for the biogenesis of the embryo sheath, an extracuticular endosperm-derived structure at the surface of the embryo. Required for the separation of embryo and endosperm, and for normal progression of the embryo through the endosperm tissue. Required for the formation of a normal embryonic cuticle.
Subcellular location: Secreted {ECO:0000305|PubMed:28696222}.
Interaction partners:
- Probable zinc metalloprotease EGY1, chloroplastic
- Protein GAMETE EXPRESSED 2
Sequence:
MMSIKLTLCALIFFLLNSLLHHVLGHDNQLNTTSSWLKSHIKAATTTNWGRPKPPMCKPWICKRSGPSEARMRCCRNQCVDVLSDPNHCRFCFKSCRFALSCCDGDCVDTNTDPSNCGQCGNECESGAPCEFGMCGYAAPSSQPGKRHRRHKFHRPRPPPSPDSKLNYDDHDDE
Protein: Phosphogluconate dehydratase (EC 4.2.1.12) (6-phosphogluconate dehydratase) (Entner-Doudoroff dehydrase) (P0ADF6)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.
Interaction partners:
- KHG/KDPG aldolase
- Glucose-6-phosphate 1-dehydrogenase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Thermoresistant gluconokinase
- Thermosensitive gluconokinase
- Glucokinase
- 6-phosphogluconolactonase
- 2-dehydro-3-deoxygluconokinase
- HTH-type transcriptional regulator HexR
- Glucose-6-phosphate isomerase
Sequence:
MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSAHQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPGLTMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQLPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINWDDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVRELLKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEKSLDSNVIASFEQPFSHHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPKANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEAELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATCITF
Protein: Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G) (Q9BZR8)
Organism: Homo sapiens (Human)
Function: Plays a role in apoptosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11054413}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system. Note=Predominantly localized to cytosolic organelles.
Interaction partners:
- Ubiquitin-like protein FUBI
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 3
- Cellular tumor antigen p53
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 14
- Bcl-2-like protein 1
- Trafficking protein particle complex subunit 4
Sequence:
MCSTSGCDLEEIPLDDDDLNTIEFKILAYYTRHHVFKSTPALFSPKLLRTRSLSQRGLGNCSANESWTEVSWPCRNSQSSEKAINLGKKKSSWKAFFGVVEKEDSQSTPAKVSAQGQRTLEYQDSHSQQWSRCLSNVEQCLEHEAVDPKVISIANRVAEIVYSWPPPQATQAGGFKSKEIFVTEGLSFQLQGHVPVASSSKKDEEEQILAKIVELLKYSGDQLERKLKKDKALMGHFQDGLSYSVFKTITDQVLMGVDPRGESEVKAQGFKAALVIDVTAKLTAIDNHPMNRVLGFGTKYLKENFSPWIQQHGGWEKILGISHEEVD
Protein: lysozyme (EC 3.2.1.17) (Q5MY96)
Organism: Streptococcus phage NCTC11261
Interaction partners:
Sequence:
MATYQEYKSRSNGNAYDIDGSFGAQCWDGYADYCKYLGLPYANCTNTGYARDIWEQRHENGILNYFDEVEVMQAGDVAIFMVVDGVTPYSHVAIFDSDAGGGYGWFLGQNQGGANGAYNIVKIPYSATYPTAFRPKVFKNAVTVTGNIGLNKGDYFIDVSAYQQADLTTTCQQAGTTKTIIKVSESIAWLSDRHQQQANTSDPIGYYHFGRFGGDSALAQREADLFLSNLPSKKVSYLVIDYEDSASADKQANTNAVIAFMDKIASAGYKPIYYSYKPFTLNNIDYQKIIAKYPNSIWIAGYPDYEVRTEPLWEFFPSMDGVRWWQFTSVGVAGGLDKNIVLLADDSSKMDIPKVDKPQELTFYQKLATNTKLDNSNVPYYEATLSTDYYVESKPNASSADKEFIKAGTRVRVYEKVNGWSRINHPESAQWVEDSYLVNATDM
Protein: Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) (P15260)
Organism: Homo sapiens (Human)
Function: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10811850, ECO:0000269|PubMed:28883123}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Interferon gamma receptor 2
- Signal transducer and activator of transcription 1-alpha/beta
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK1
- Interferon gamma
- Interferon alpha/beta receptor 2
- Interferon alpha/beta receptor 1
- Non-receptor tyrosine-protein kinase TYK2
- Suppressor of cytokine signaling 1
- GTPase KRas
Sequence:
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
Protein: Angiogenin (EC 3.1.27.-) (Ribonuclease A) (P27043)
Organism: Gallus gallus (Chicken)
Function: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P03950}. Nucleus {ECO:0000250|UniProtKB:P03950}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P03950}. Note=The secreted protein is rapidly endocytosed by target cells following interaction with PLXNB2 receptor and translocated to the cytoplasm and nucleus. In the nucleus, accumulates in the nucleolus and binds to DNA. {ECO:0000250|UniProtKB:P03950}.
Interaction partners:
- Uncharacterized protein.
Sequence:
MAMSSLWWTAILLLALTVSMCYGVPTYQDFLRTHVDFPKTSFPNIAAYCNVMMVRRGINVHGRCKSLNTFVHTDPRNLNTLCINQPNRALRTTQQQLPVTDCKLIRSHPTCSYTGNQFNHRVRVGCWGGLPVHLDGTFP
Protein: Uncharacterized protein (Q583U2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mitochondrial SSU ribosomal protein
- Uncharacterized protein
- Uncharacterized protein
- Mitochondrial glycoprotein-like protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- 30S ribosomal protein S8, putative
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLIRRLRRPHSTVRGCRISSASNSDSAGAFSANGTQLPDPPYYLPHSPRFDAERCGTFNKKWLLNLPALKPLVRNSTYLPKKEELWRAPTHEALETIIGHLPYHDALRYITEHSLFLLFPTVLRARDAPLPHVIYEDFMKSCTFASLQNPPEEQFALPSVLLRTLLCMAAYHCTLDADYFTTCQMLFGRMEQQQQTTPEVLSAWVYCCTASGRVDEALTYAKYMADCSAPFDVTVFSLMQHPSLNPIEVEDGSVPHSAKGLLLQRRLGNRLHTAYRSDAVAAHGMFVYYALTLSHVRKWEVIRAAAALGVTLAERTVVLAVEVFAREKGMRCGPKTVKALTHFLAQDGTVGHLLYVLLRARKNELLPEFRDLPHTTFSEEEQELVLQCVAQRARHDDSFAVAATLVSSLVREDDPSELLMAFARAARNHHSADVCGGDGDGSVCADVPAPVPESPPSNSSEIIEKDRWAVVQASVRSLLLDVNALDQASRRDAYHKHWKNGNKGVKNKENVLAKTLTLPHDSMHTATIQRKEKELWELMRSDTPVGVRELAQLNIMEELQEAKRLERAEMAWVNPDGTF
Protein: Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] (P55215)
Organism: Rattus norvegicus (Rat)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity).
Interaction partners:
- CASP2 and RIPK1 domain containing adaptor with death domain
- P53-induced death domain protein 1
- BH3-interacting domain death agonist
- Caspase-8
- Caspase-9
- Apoptotic protease-activating factor 1
- Caspase-3
- Caspase-1
- Caspase 7, isoform CRA_c
- Caspase-6
Sequence:
MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT
Protein: Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) (Q00325)
Organism: Homo sapiens (Human)
Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12234}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P12234}.
Interaction partners:
- E3 ubiquitin-protein ligase RING1
- Chromobox protein homolog 1
- Polycomb complex protein BMI-1
- ATP synthase F
- Polycomb complex protein BMI-1
- ATP synthase F
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Polycomb group RING finger protein 2
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
Sequence:
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTQ
Protein: Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (P01223)
Organism: Bos taurus (Bovine)
Function: Indispensable for the control of thyroid structure and metabolism.
Subcellular location: Secreted.
Interaction partners:
- Glycoprotein hormones alpha chain
- Thyrotropin receptor
- Prolactin
- Follicle-stimulating hormone receptor
- Lutropin-choriogonadotropic hormone receptor
- Prolactin-related protein VIII
- Placental prolactin-related protein 3
- Growth hormone E4
- Prolactin-related protein 14
- Pituitary-specific positive transcription factor 1
Sequence:
MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYMVGFSI
Protein: Arginase (EC 3.5.3.1) (Q10066)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Ornithine aminotransferase car2
- Ornithine decarboxylase
- Ornithine carbamoyltransferase, mitochondrial
- Arginase
- Spermidine synthase
- Urease
- Arginine biosynthesis bifunctional protein ArgJ
- Peptidase M20 domain-containing protein C757.05c
- Probable argininosuccinate lyase
- Argininosuccinate lyase
Sequence:
MSPHKISDNHRHLMLSRFMMGNGVSIINMPFSGGQPKDGAELAPEMVEKAGLVDDLEHLGYDVKLIQNPEFKSRPSKEGPNQALMKNPLYVSNVTRQVRDAVQRELEQQRVVVNIGGDHSLAIGTVEGVQAVYDDACVLWIDAHADINTPESSPSKNLHGCPLSFSLGYAEPLPEEFAWTKRVIEERRLAFIGLRDLDPMERAFLRERNIAAYTMHHVDKYGIGRVVEMAMEHINPGKRRPVHLSFDVDACDPIVAPATGTRVPGGLTFREAMYICEAVAESGTLVAVDVMEVNPLLGNEEEAKTTVDLARSIVRTSLGQTLL
Protein: Paired immunoglobin like type 2 receptor alpha (C9JJ79)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKLHLTQSTSQPPSPQEPPERDPVLCLKGLTNGQPSQD
Protein: Hydroxyproline-rich glycoprotein family protein (Serine/proline-rich) (Q9M1T6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Classical arabinogalactan protein 1
- Non-classical arabinogalactan protein 31
- Fasciclin-like arabinogalactan protein 4
- Beta-1,6-galactosyltransferase GALT31A
- Hydroxyproline O-galactosyltransferase GALT2
- Fucosyltransferase 6
- Beta-glucuronosyltransferase GlcAT14A
- Probable fucosyltransferase 4
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Beta-1,6-galactosyltransferase GALT29A
Sequence:
MKLEFIIVAMMLSLVLVSGEILTKSSPAPSPDLADSPLIHASPPSKLGSHNSPAESPIEYSSPPEPETEHSPSPSPANSPSVSPPLPNDSQSPSSSASPSPSPEASDVNHSDITGIEGEKLPSGSGGGMSGGKKVGVAFGAIAAVCVVGVAGFVYKKRQENIRRSRYGYAAREIL
Protein: Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) (Q92123)
Organism: Xenopus laevis (African clawed frog)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGYGAGRDKYEPAATSEQGGKKKKGKGKGKEKDMDELKKEVTMEDHKLSLDELHRKFGTDMQRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAAMEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRSGEKLSINAEEVVLGDLVEVKGGDRIPADLRVISSHGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRIATLASGLDGGRTPIAIEIEHFIHIITGVAVFLGVSFFILSLILQYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGASFDKSSPTWTALSRVAGLCNRAVFQAGQENTPILKRDVAGDASESALLKCIELCCGSVRDMREKNHKVAEIPFNSTNKYQLSVHKNANPSESRYILVMKGAPERILDRCTSIILQGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLALPDDQFPDGFQFDTEEVNFPTENLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVIHGTDLKDMTEEQIDDILRHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPWTLLGIRVNWDDRWTNDVEDSYGQQWTYEQRKIVEFTCHTSFFISIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLIIFIYDEVRKLIIRRSPGGWVEKESYY
Protein: WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) (Q15061)
Organism: Homo sapiens (Human)
Function: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24219289, ECO:0000269|PubMed:34516797}. Nucleus, nucleolus fibrillar center {ECO:0000269|PubMed:24219289}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6ZQL4}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 6 homolog
- Nucleolar protein 56
- DDB1- and CUL4-associated factor 13
- U3 small nucleolar RNA-associated protein 4 homolog
- HEAT repeat-containing protein 1
- U3 small nucleolar RNA-associated protein 15 homolog
- WD repeat-containing protein 75
- Nucleolar protein 58
- Nucleolar complex protein 4 homolog
- WD repeat-containing protein 46
Sequence:
MAAGGGGSCDPLAPAGVPCAFSPHSQAYFALASTDGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLISGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLMFTTIRPPNESQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVYGSWFQPTIERVALNSREPHMCLVRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAIKPAPPQTEQVESKRKSGGNEVSIEERLGAMDIDTHKKGKEDLQTNSFPVLLTQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLITQVTASEKTKGATSPGQKAKLVYEEESSEEESDDEIADKDSEDNWDEDEEESESEKDEDVEEEDEDAEGKDEENGEDRDTASEKELNGDSDLDPENESEEE