Protein: Hydrocephalus-inducing protein (Protein Hy-3) (Q80W93)
Organism: Mus musculus (Mouse)
Function: Required for ciliary motility.
Subcellular location: Cell projection, cilium {ECO:0000305}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30535028}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q4G0P3}. Note=Localizes in the cilium axoneme in a SPEF1-dependent manner. {ECO:0000269|PubMed:30535028}.
Interaction partners:
- Protein O-GlcNAcase
- Dynein axonemal intermediate chain 1
- Abnormal spindle-like microcephaly-associated protein homolog
- Radial spoke head protein 4 homolog A
- Coiled-coil domain-containing protein 39
- Radial spoke head protein 9 homolog
- Dynein axonemal heavy chain 5
Sequence:
MTLKIKCVANYIKEKIPNVLFLCDPEARLQQLTASVPLCEQRKYFKQTNKRLEESMGAMHRKMAKVISGLQSKVLPPMSPKVVTEEEVNRMLTPSEFLKEMSLTTEQKLASTRIICRPQITELLDMGETTHQKFSRVDLDQALFQPFPSEIIFQNYSPCEVYEVPLVLRNNDKIPRMVKVVEESSPYFKIISPKDIGHKVAPGVPSVFRILFTPEENKDYAHMLTCITEREKFIVPVKARGARAILDFPDELNFSTCPVKYNTQKVLLVRNIGNKDSMFHLKTRSPYSVEPTGGILNVGESMQLEVDFEPQTVGSHDGKLIVTYDTGEMVFVCLYGVAIDVNIRLDKNSLIMEKTYISLANQRSITIHNRTNIIAHFQWKVFATEEEEDKEKYKICDGLNKEEKQETSMILEDSVLDPSLRERLSIISRTFENQRKLVQGDSMLFLDHVFTIEPPEGDVWPNSSAEITVYFNPLEAKLYQQTVYCDISGREIRLPLRIRGEGMGPKLHFNFELLDIGKVFIGSAHCYEAILSNKGSIDALFNVIPPTSALGACFVFNPKEGIIEPSGVQAVQISFSSTILGYFEEEFLIDVNGSPEPVKMTIRGCVIGPTFHFNVPALNFGNVSYGFPHTLMCSLNNTSLVPMTFKLRVRGDGEGMSSIPSYSQESDSKQWSGINTEMPTTKPKEFTISPNSGTIRAQGFTAIKVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVPKLQLVTTEVDFGRCFLKYPYEKTIQLVNHDDLPGCYKVLPQLYENSPPVLLSSPSPCGVISPHSTVSIPLALETQVIGAHRSIVYISVFGSQEAPLACNIQSIGEGPVIFIHPTQIDFGNIYVLKDTSRILQLSNQSFIPAVFRVRMANKKSLWTVKPSEGAVPAEDDIPLTLTANLDDIVTFKDTVILEIKHSNTYRIPIQATGIGSTIVSDKPFAPELNLGAHFSLDTHYYRFKLTNKGRRVQQLFWMNDDFRPKEKQSKKEPGKKGSTSSSRRQSKASQEPTDNGNPVFQLYPVRMELYPGQTIDVILEGYSATPKKVKEKLVCQAIVGTQKGKSLLMSVNIICEFIAPIIQLSAKQLLYRLEKKPNSNLESDYQSLVIKNITTLPVNMLLSTTRPFFICETDKSLLPATPKPIKLEVDEEKHLLIKFDPSYRNDLNNWVAEEVLSIKYLEHPQVDNLGLRAEVHYPNLSFEVMDIDFGCILNDTEVIRYIMITNCSPLVVKFRWFFLVDEEENQIRFAPCMKPYSAFLSQMESIAATSVTASSLAAPHTVEYTEMDFSDSIKTILMDDEAGPEEIKKPATSTMVSEAIKYSSAGTERSQSQPDYPECMWIYEQDEMLSIGIEEVFDILPLYGVLRPYSSHQISFTFYGHCDIIARAKALCEVEGGPTYEVLLKGEASLVNYSFDTKDINYGLQLFDHVTEREITLKNTGKVGFEFNVLSNYRSSQRNLLPGVPLILPLSGFIQSNKEQVLKVYYLPGIPEVFQRNFQIQIAHLVPENITLYGEGIFPRISLDLHRNLQGNEKYEHFLEQAKKNVEKEYTKYEAVDQYEVMAEELPEEETAEISAHVQMEVERLIVQDYALEHQRSISNNTEDIYFSQRSCRKLTKVQLPEYILDFGYIVLGDVRTHIVKITNTSHFPVSFHAEKQVLHETGFSTELDRVKNLPYYETETFEVRCDPQGANLPVGNKEVILPIKVYGGPTIHLCLQATVIIPSMTLSCNKIEFATIQCGQCMVETIQLSNHLQVPCEWFVHTPKSTNKLDKHMPKYLRRKLQAEMIPKSRIFEIQPTSGILDPGERANVQVKFMPKEEKLYSQSLLFQIGQSSQKLTLLAQGQGLEPRLEFSPSVLELGPLLPFASGDEAEVIVRNPCNFPIEFYSLEFDQQYLLEEKMLRQLKGYDSYNTLLLPPRNPGEKLPPEVYDYFKEMKKSKEEHMKAKYMENLENEEEEMNTSDQGTTSTKRTSISRGISVTSNLEERHLTIEAKNYLDEDDYEESLEKLTFQTDKMQSTDSHSVEEVGEVESNPVSKAIARHLGIDISAEGRLAKNRKGIAIIVHGTPLSGKTANAISMAKFYNAACLNIDSIVLEALSDTNNILGIRARELCIRAAIEQSMREAEESAHESSMTQNTVVPARLSTENLGRFTSELTLITQEYKVPKTVRGSVMLPKGKADSHFTGSQKQHHQHQSETPQVQISSSPLLPGPTHRRLSVSASIGGETGLMSCVLPDDLLIQILAERIQLSNCFRGVVFDGLDTLFARNAPSALHCLLKAIGSREHIYVINMSQDYVVMKAQEKAKKEQEENKRKEALAKEKERLQTLDEDEYDALTAEEKVAFDRDVRQALRERKKRELERLAKEMQEKKLQQELERQKEEDELKRKVKRPKAGPAAKEEPPLKKAQGATNKQLAAVAKIELKMESIERKVSVREHATLEETTRKKKAMTEYPLLIPISQEQEDSEGDFLKDSDKNLAQKFKIYDMCLKDVQNILMYWDRKQGMMVPHTGTDEMSHEADDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLEKLKALEERSDVEGEGEEEHEGKKDLGVPFINIQSPDFEGVSWKQALESDKLPKGDQILDILGLGSSGPPIPPPVLFSIISYPAKRQSLVATEILKHFVFVIPPNDDIPLMDEKKDPEGDSDIFLNTIITKAQEEQPSPPKGSKQKLKDKPEQVRETQKEKRRTYSSRKGLPGGTSGSIVPMSDIDQNSFDGEHSQEKFIRLNHFRWIVPPNGEVTLRVHFSSLDVGNYDQTFNFELLGTRRQYQLYCRGVCTYPYICRDPKVVFSQRKKDMKLKEVVVKKYVVSMEKFYFGPLLCGKSRDKYKSSLFPGNMETLTILNDSPMVVEAYFCFQHDIKASTYFLEPVNMTLKPNEKQALNVWAYPTAVGIFEDSIVCCIKENPEPAIFKLSCQGIRPEIEVEPRQLHFDRLLLHRKETKIVILRNVTPLPVAWRISNLEHLGEDFTVSMMQGTMLPKGEYGLQVHFQPSKPVNIKKAIRIEVLDAENLVGVVQIENILIFAESYDIALDITFPKGAEGGLDFGTLRVMEEVKQTLQLKNRGKYEIIFSFTVDTLGVLPTNLSSMISVQPKRGTLASIDKPTTVQVFFRARKEVKIDCQPILRCQIIEPTLPEGEIIASIPIKFSVNAVYSKFTISPSSIINFGALICGTRKSITFTIENQGIIDFKYALYRLTGESPILQKKITSHMRHGRTRESESFYKPGATKMAKFSDTVQKDTNIANQARFTHGMFTVYPGFGSIPSGGQQVITIECFADPVGRCEEFLAIDISDRDPRENPAGIPYTLLAEACLPAFVTDNNILIFEEHQICTSPNLYHILQTIQSGGLFVEDENKFIFCNVLVGHQAKARFKISNVGKISCDINIVIKPISNKPANRITDTFDVEPSKMCIGSRSHAFVTVLFTPQTMQTYQCIFEATLDGLPSNIARSRGLVFDIVGEGTLPRVTVIRPTLYNQHGNPLLLFKRLLLGHSEKLPLILKNNGTIPAQLHVDLRDQLGVFSLKGRPTTSYIYIMEENKPNEKVKKAHTASLVVSPGDTAEFDVFFHSNKIGRMTGTIHLSVINNQYEETMIHLVGESYEDDITLDNIHGLISSTSQESSDKSEVIEIAEESTMEDLVTAALMEHIQFGYCHIGISYNVSFTITNHSQVNVIRFEWPLLATLSFSPQIGHLHPGCSKDVVVTLKSESPITLKKMCVKCKLSKIMFQLPVDQVPDWDDRMRTVKWVDAPRNTPLTLNTKRKVIEMDPEPAHSVVEENYRELRIQFSANVDFASYQCETTEVFFKETLVYQTRVFEFDLVNTGQVLLEFCWISEEASKAVSFAMPERQGSSQKELSQGSGSSLDSALDRWTEASPSPFSVEPPSGVVPVGKTQKLKVKFSPMDIGEFESSLYCQIPNLPLGEQGPILITKGRSVLPFCHFDLKESDYISGHRRNPELRGPGAGPLEPNTRVIEFTSVGIGGKNVQTFTILNPTNSTYSFCWTSEETESLQHPPAFVCLTEKGIIHPEKKAEIIFQFLPAHLDITEEFWTFSIPEHNISVPFLLVGKTTDPLISLDKSHLNFSSLLIGREARETVKIINKEEQGFNFAFQDNSRYSEGFNNSLIVCPMEGWIPPLSRFPVDIFFTPKQEGDVNFNLICNIKKKAHPLTLNVKAEGYTMNAEVKCRDRMGTTILLTSTQVNTINFYEVELNECVQCEFSFINTGKFNFSYQAELSGPKLLLQYLDFTPTDSSVDVGQSEPANLSFQPYQKCVLKGLELKIKISHGPTFVCNILGCAVSPAVHFSFTSHNFGTCFIYQAGMPPYKQILVVTNKEETSMSLDCLYTNTPHIEVNFNVDVIKPGKTLEIPITFYPREAISYRELIPFEINGLSQQTVEIKGKGTEMKLLVLDPANRIVKLGAVLPGQVVRKTVSLVNNSLAQLTFNHSVLFSIPELQEAKVITLEPFHTITMKPKEVCKLEITFAPKKRVPPFSEEVFMEWMGLLRPLFLLSGCCQALEISLDQEHLPFGPVVYQTQATRRILIMNTGDVGARFKWDVKKLKPHFSISPEEGYIISGTEVALEVTYHPTEIGKESLYKNILCFIQGGNPLCLTLSGTCVGPPVVKEVVNFNCQVRSRHTQTILLSNRSNQTWNLHPIFEGEHWEGPEFITLEAHQQNKPYEITYKPRTMNLENRKHQGTLFFPLPDGTGWLYALHGTAELPKAVANIYREVPCKTPYTELLPISNWLNKPQRFRVIVEILKPEKTDLSVTLKGLDYIDVLSGSKKDYKLNFFSYKEGLYTAKVIFRNEVTNEFLYYTVSFRVTPSGIIKTIQMTSPVRQSVSASIKLENPLPYSVTFSTECKLSDISLPSQFAVPPNSEGTFSFEFQPLKAGELCGRLTLHNSDLGYYQYELALKALPAPPEKPVHFQTVLGSSQSILAKFTNYTRLKTEYYCKTDCSDFHTEKVINAAPGAQGGTEVSVEVFFEPSHLGETKGILCLSSLIGGEYIIPLFGIALPPKPQGPFLIRAGYNIIIPFKNVFLHATSFSFIVENPAFSIRAAETVRPKKINNITVYFEGNPSGSKTPITSKLIVTCPQCEGTESGIKWVYYLKGITP