wanglab/gogpt-training-data huggingface dataset:
Protein: Myosin heavy chain-like, isoform G (Q0KI67)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFNFMKKSAGDEDKERRKREKKLRKEAKGTSGGPGMGGVTGVTGSMSTDELLRLDEVRRSLKIRGRRKEKEKLPSGITADYSADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHIESRASNGAGVSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRYADNEVNSNSRKQHKH
Protein: SSD domain-containing protein (Q9XXR9)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ground-like domain-containing protein
- WaRThog
- Ground-like domain-containing protein
- Ground-like domain-containing protein
Sequence:
MRFDCIEKRFAHAFGAYSGVVVRHPFPFFIIPILITAGLSTGLLRHEQAFMKDELELYTPTDAQARKELSQLDHLFHINDSDPFYATRRYDIRRAGYIIVTNQEEDGDILNPLVMHSAMQLWSIVQSLTVEDEDDRRINYPSICVKFPIPPEFSKALHSLFAPNMTTPEEICVSNPLVEIFKLLLVSDRSFLNRSIDEMTLSQISDAIQFDSGGMTHLLGGVTLDDDKRIAGAKAMLLPYALRHSSDDEDWVAEKWEVRLADFLLQYDSPIIRASWWTYETLAAESARDRLQLIHMLLPCFVCVSIFTIACCCVFSWRRSRPWLAIGGVISAAMAIASAVGILLLAGYGMTSVAYSMPFIVFSVGVDNVFILLSAWRSTSSTETLEHRMKETFADAAVSITVTSLTDLISFGVGCATPFPSVQMFCAYAVAAVIFTYIYQLTFFAAVMVYTNRREINNRHCIFFHKLKKDTLPEKIAAQGDRSFEKNTILAQFFRTTYSDFLLNPLVRIVILVTFCVYLGVASYGCTKVKLGLEPNDLLPENSYGKRTLMMAEKYFSDYGSSLHVWMYNLSEVDVAPRKIWNVLEKEVELYEHTEFTASSDSWLRTFLAFVKQAGLLITPENFVYILKNVFLSQPQFAKYNRDVVLTEDGEHLEASRIPVQLRHVGSANQSRAMRLFRRLAETSELQTGVYADFFQFAEQYNAVLPGTLSSIAYAGVAVVAVSLILIPEPVASLWVSFSIVSINIGILGFMTFWSVRLDFISMVTIVMSIGFCVDFAAHLAYNFAKGQNMDGSERMRNALYAVGAPILMSATSTIIGVSFMASAESYVFRSFLKTIMLVILLGALHGLVILPVLLSMFYCGGSSKKAKEHIDAVDQKLQAQYNNPARTASIQFLSNPDLYTMPPPPSVEYSLSTLEFNRTQSRPLGAPPALTGSPKRELSGLSGPPEYEEHDPTGLSTFGVSPAVVANTTGMIPMRAKLKYPSSMTQRRDSESRSTPELYYPS
Protein: ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32) (Q8K273)
Organism: Mus musculus (Mouse)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). May be involved Mg(2+) transport.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N4V1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N4V1}. Golgi apparatus membrane {ECO:0000269|PubMed:18057121}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N4V1}. Early endosome membrane {ECO:0000269|PubMed:18057121}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N4V1}.
Interaction partners:
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 2
- Endoplasmic reticulum membrane protein complex subunit 7
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 9
- Predicted gene, 27021
Sequence:
MAPSLWKGLVGVGLFALAHAAFSAAQHRSYMRLTEKEDESLPIDIVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFRPSDATNSSNLDALSSNTSLKLRKFDSLRR
Protein: RE53485p (Q86NL2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNMSRLTPPADAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS
Protein: Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1) (P15790)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Phosphorylates YTA7 during S-phase to promote transcription of histones.
Interaction partners:
- rRNA biogenesis protein RRP36
- Nucleolar protein 19
- Casein kinase II subunit alpha'
- Casein kinase II subunit beta'
- U3 small nucleolar ribonucleoprotein protein IMP3
- Casein kinase II subunit beta
- Ribosome biogenesis protein SLX9
- U3 small nucleolar RNA-associated protein 22
- U3 small nucleolar RNA-associated protein 18
- Ribosomal RNA-processing protein 7
Sequence:
MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit) (O35683)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000269|PubMed:38575788}; Matrix side {ECO:0000269|PubMed:38575788}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase 1 alpha subcomplex subunit 3
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8
Sequence:
MWFEILPGLAIMGVCLVIPGVSTAYIHKFTNGGKEKRVARVQYQWYLMERDRRISGVNRYYVSKGLENID
Protein: SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia) (SUN-like protein 1) (Q8C341)
Organism: Mus musculus (Mouse)
Function: Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation.
Subcellular location: Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:20440000}; Single-pass type I membrane protein {ECO:0000269|PubMed:20440000}.
Interaction partners:
Sequence:
MKKYRRALALVSCLSLCSLVWLPSWHVCCKESSSASTSYYSQDDNCAIGSEDTQFQKKNEREEPSNAELSGKSNSYLTISPEGNKIKDDYTVDVQDLETTKLSLPVVEALPTVDLHEESSSVVVGSETIENSSSSSTSERTPVSELDEVEKSGTLSIAKPGEVEQPEADCDAGEAPDADAPVEQPAFVSPPESLVGQHIENVSSSHGKEKVTKSEFESKVSVSEQDGGDPKSALNTSDTLKNESSDYTKPGETDPTSVTSPKDPEDIPTFDEWKKKVMEVEKEKSQSLHPSSNGGPHATKKVQKNRNNYASVECGAKILAANPEAKSTSAILIENMDLYMLNPCSTKIWFVIELCEPIQVKQFDIANYELFSSTPKDFLVSISDRYPTNKWIKLGTFHGRDERNVQSFPLDEQMYAKYVKMFIKYIKVELLSHFGSEHFCPLSLIRVFGTSMVEEYEEIADSQYQSERQELFDEDYDYPLDYNTVEDKSSKNLLGSATNAILNMVNIAANILGAKTEDLTEGNKSISENATATTEPKMTESTRVSTPVPSPEYVIKEVHTHDREPSTSDPPKESPIVQLVQEEEEEASPSTVTLLGSGEQEDESSSWFESETHILCSELTSICCISSFSEYIYKWCSVRIALYRQRSRTVSKGKDFVPPQPSLLLPVESVEVSVPQPPSGDVDSENMEREAETVDLDDLSSVHQGHLINHTVDTIELEPSYPQTLSQSLLLDVTPEMNSLSKVEGSESVKSEGGYIPSQLMTQESSVEFDDKTEKKTESFSSAEKLSVIYETSKVNEVMDNTVKEDILSTEVVTKFPETVVPPPMNTATVPEGESVETKPSIADTLKHTVTPVMDPSLPEVKEDEQSPEDALLRGLQRTATDFYAELQNSTDLGYGNGNLVHGSNQKESVFMRLNNRIKALEVNMSLSGRYLEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIHLLQAQLTNMTQLVSNLSATVAELKREVSDRQSYLVMSLVLCVVLGLMLCMQRCRTTSQFDGDYISKLPKSNQYPSPKRCFSSYDDMNLKRRTSFPLIRSKSLQFTGKEVDPNDLYIVEPLKFSPEKKKKRCKYKTEKIETIKPADPLHPIANGDIKGRKPFTNQRDFSNMGEVYHSSYKGPPSEGSSETSSQSEESYFCGISACTSLCNGQTQKTKTEKRALKRRRSKVQDQGKLIKALIQTKSGSLPSLHDIIKGNKEITVGAFGVTAVSGHI
Protein: Dynamin-like protein (Q8IJ32)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- non-specific serine/threonine protein kinase
- Uncharacterized protein
- Mitochondrial fission 1 protein
Sequence:
MDKLVPIVNKLQNVLSSFISSETLSLPHIAVVGAQSVGKTSLLESLVGLSFMPKGEDIVTRTPIIIQLTNSKSDDCYCTLTYCDYDNNRVEKHIDDFSILNEILIDVTEEITGGNKCIKETPIIIEIHKNDVLDLTLIDLPGLTKVPVGNQPQNVEEQIVNLVNKYIKNPNCIILAVSSANIDLANSDSLKMARNVDPKHERTIGVITKCDMVEKPEIWKKMISGSLYPLKKGFVAVVCRSQKDVEDDITIEMSIKKEEEYFSQCIDFSNQMECIMECGIKNLAKKLNNILIEHIKNTVPFLKPKIDSLKSIEEERLLELGEPMDNMNRSEYLAVLVNYITKFSQQYQDIIDGKVFYKDRVDELKGGARIHYIFNDWYIKSLNDFSPLEMLTDEEIRIAIRNSSGPRGALFVPESAFETLIKKLINCLKEPSLRCADQVYEELLKIVDNCRIADMERFTNLKSAINEQVKILLKDCLQPTKEMIKNLMLIELSYINTSHPDFLNEHFMKNVYDKDNDYIDELDTVVHPKHNHKMLQRPKREYQETCGSNMNYSTIHHNNTYKEEMKMWKHKEDAKSFRNKEGTKITNINNNRENVFVLPVIPEKIIPEYSSSSKEIIEIDLIKSLINNYFNIVRKHIADAVPKAIMHFMVNTSRKTMQKVLISNLHNGELFNLFNECSSIKVKRNNCKKNLESLNQAIKMLAEIRNQEV
Protein: Coronin (D6W4T8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAWRFKASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHTGSSVAVLPLDDCGRKSKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSLSDPEAIFSHKQRRVETVGFHPTADGLMYSTAAGCVALFDLSTQKEIFSNNEHPEVIQSASWREDGSVLATSCKDKNVRIFDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRDVRNFNTPEKTLELDCSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTGEQTKGACLVPKRALKVMEAEVNRVLQLTSNMVIPIMYQVPRKTYRDFHADLYPETTGYKTELVAGEWLNGSNQAVPKMSLDPAKREHGDEPIIIHRGNLSDFVKNLENQRAKSNTTGKPNQQAKRNDNEHFVMLNTGNNFEEKNGNDNSNESNGKKSTPSQSQPDGECSELIRKFEAKYKVDSEKEKAHAYAQSHEDDKESPTEHEHSTGSSEEVSSSGGLDNHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTNTPRPRPRTTAASAYKPRLGPKPFSSTTGDVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAKPDLIVEIEIKKKHEREPAVSGNGVQKSLTTSERRKSSADDDESSDKIFEQNSESSENSTEGEDRTDADLRRNCTSRSSFAERRRIYENRSKSQVDEKPQSPVPLRREHSKVEPLKPNQQQQQQGNVIDTKRISVPEGKLMEEHRRGNGAGLKKSATEAAFSAASTKRTSTVFGKVSKFRHLKGTPGHKSTHIENLRNLSRQIPGECNGFHANQERVAVPLSGPGGKIAIFELSRPGRLPDGVIPSLVNGSNIMDFQWDPFDAQRLAVACDDGIVKIWHIEAGGLSEPTNTPAGELTAHLDKIYFIRFHPLAADVLLTASYDMTIKLWDLRTMTEKCSLSGHTDQIFDFAWSPCGRLGATVCKDGKIRVYNPRKSETPIREGNGPVGTRGARITWALEGHYIVCTGFDKVSERQISVYNAQKLSAPLNTASLDVSPSILIPFYDEDSSTLFVTGKGDSTIYCYEITDEEPYICPLSHHRCTSLHQGLSFLTKNHCDVASVEFSKAYRLTNTTIEPLSFTVPRIKSELFQDDLFPPTRITWSATLSSEDWFASNDKAAPKVSLKPEGMETLSSIQQVPAQPVKKPDHPQFGGQKSEYEINKQQEIQKSVSARMEFTTKLEQDDMEGVDENEWQE
Protein: Transthyretin-like protein 52 (G5ED35)
Organism: Caenorhabditis elegans
Function: Plays a role as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1. Important for the generation of extracellular phosphatidylserine vesicles that promote loss of the exoplasmic leaflet from apoptotic cells in a time-dependent manner. Required for the exposure of exoplasmic leaflet on the phagocytic cells surrounding the apoptotic cells. Does not affect the phosphatidylserine externalization in living cells. May play a role in mediating transfer of phosphatidylserine from phosphatidylserine vesicles to ced-1 bearing phagocytes or alternatively result in the activation of a phosphatidylserine transporter in the phagocyte that promotes phosphatidylserine externalization.
Subcellular location: Secreted {ECO:0000269|PubMed:20526330, ECO:0000269|PubMed:22713871, ECO:0000269|PubMed:22727702}. Cell surface {ECO:0000269|PubMed:20526330, ECO:0000269|PubMed:22713871, ECO:0000269|PubMed:22727702}. Note=Detected almost exclusively on the surface of apoptotic cells. In some embryos, also observed on surface of cells adjacent to dying cells. {ECO:0000269|PubMed:20526330, ECO:0000269|PubMed:22713871, ECO:0000269|PubMed:22727702}.
Interaction partners:
- Cell death abnormality protein 1
- Nose resistant to fluoxetine protein 5
- ABC transporter ced-7
- Cell death protein 6
- Bifunctional arginine demethylase and lysyl-hydroxylase psr-1
- CED-5
- Cell death abnormality protein 2
- Phospholipid scramblase
- Integrin alpha ina-1
- Ras-related protein ced-10
Sequence:
MSRFLIYFLPFFIYSGNVLSKTSCLMATGVLKCPTDPEAVKKVHIDLWDEDSLPLESDDLMGRTWSDRNGNFQVTGCASDFGPINTPDPYLYIQHNCPHRDSNATNPIQIDVIPLFLPSIVRLGNVYLDRYLEDY
Protein: G2/mitotic-specific cyclin-B1 (P14635)
Organism: Homo sapiens (Human)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Interaction partners:
- Separin
- Cyclin-dependent kinases regulatory subunit 2
- Anaphase-promoting complex subunit 4
- Cell division cycle protein 20 homolog
- Serine/threonine-protein kinase PLK1
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 10
- G2/mitotic-specific cyclin-B2
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
Protein: Cytoplasmic response regulator (Eurofung) (Q5AVI3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Histidine-containing phosphotransfer protein
- MAP kinase kinase kinase
- Mitogen-activated protein kinase hog1
- High osmolarity signaling protein sho1
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase kinase
- Transcription factor
Sequence:
MSERRWSTRIKEKGFRLLRRSSTSSRHSKNLPLVTASTSNSTHDLHPPRSRHSQYSQPVDGAYQGQKAAEAPAGPDSEPNSASSATTTPPISTPNALANPPPLSSASRPSISSFTESQYTPDELASAGTPGGQYFFVPDYRQPTSPALPEEQSVDQTSPAKPVAREQPQSQLQESQATPRRSDHDRERAKSGASRKSVPFELLDFPLQPPGNTEPSAPVSPVRTDRSSAPPTASPNRRERPVSGPAEQQSTPLPSVAEKSAVNTYQSLPLPPAFPSRLSVFRRQSLLPASHQHLVTSILDTDSFTEPEGINKHLPTMGSGMGLRKIWVKRPGGSATLLPTSEDALVDELRDQVVIKYANSLGKTFDAPDIIIRIATREGTRPPTPDRILSPEEPLWAVVDSYYPGGQTVGEALLIEIPQRRTPKPSPHRNVYFAQSEPGEHGDYFPLMPTNINLSTPPVHQPAANNSAGAHSAPSISILTTGHAPQVPSPGGRTRTRRPPLARNITHSPTIRGMSQSKESVSSQTAAPSQPTPPVPTPPGPPAESPKTKAHTPPARVSSPRPGPVKPKKSNRASLLNGAFGGLIEGTVPPINVLIVEDNVINQRLLEAFMKRLSVRWKCAANGQEAVTKWREGGFHLVLMDIQLPVMNGLDATKEIRRLERLNGIGVFPKKSSGVSTAAAATSPDPVTEEDTLHDLSLFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVRFEWLEQKVTEWGCMQALIDFEGWRKWRGFATSESNSNTGSGRSTPETRNGTRKPSHPSPSPSAKKLSHLKKNDLVDDSPDSGDGSDSPASLHADGPSPVQDGAL
Protein: Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2) (Q96SL1)
Organism: Homo sapiens (Human)
Function: Electrogenic metabolite transporter.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:21692750, ECO:0000269|PubMed:36456177}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- von Hippel-Lindau disease tumor suppressor
- Endothelial PAS domain-containing protein 1
- HSPB1-associated protein 1
Sequence:
MGSRWSSEEERQPLLGPGLGPGLGASWRSREAAAAALPAAVPGPGRVYGRRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAESSRAHIKDRIEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSGVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFLTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV
Protein: Isopenicillin N synthase (IPNS) (EC 1.21.3.1) (Isopenicillin cyclase) (Penicillin biosynthetis cluster protein ipnA) (B6HLU0)
Organism: Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Function: Isopenicillin N synthase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic. The first step of the pathway is performed by the trimodular NRPS acvA that produces the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) via condensation of the 3 residues L-2-aminoadipate, L-cysteine and L-valine. The precursor amino acids for penicillin biosynthesis are withdrawn from the vacuolar amino acid pool by the MFS-type transporter penV. Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. The tripeptide ACV is then cyclized to form isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus. Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase aatA to yield penicillin. This step occurs in the peroxisomal matrix and the penM and paaT transporters are involved in the isopenicillin N and phenylacetic acid import into the peroxisome, respectively.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12223189, ECO:0000269|PubMed:1899377}.
Interaction partners:
- Isopenicillin-N N-acyltransferase
- Pc13g09140 protein
Sequence:
MASTPKANVPKIDVSPLFGDNMEEKMKVARAIDAASRDTGFFYAVNHGVDVKRLSNKTREFHFSITDEEKWDLAIRAYNKEHQDQIRAGYYLSIPEKKAVESFCYLNPNFKPDHPLIQSKTPTHEVNVWPDEKKHPGFREFAEQYYWDVFGLSSALLRGYALALGKEEDFFSRHFKKEDALSSVVLIRYPYLNPYPPAAIKTAEDGTKLSFEWHEDVSLITVLYQSDVANLQVEMPQGYLDIEADDNAYLVNCGSYMAHITNNYYPAPIHRVKWVNEERQSLPFFVNLGFNDTVQPWDPSKEDGKTDQRPISYGDYLQNGLVSLINKNGQT
Protein: F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) (Q96IG2)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Cullin-1
- S-phase kinase-associated protein 1
Sequence:
MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL
Protein: GTP-binding protein 10 (Q8K013)
Organism: Mus musculus (Mouse)
Function: May be involved in the ribosome maturation process.
Subcellular location: Nucleus, nucleolus. Note=Found in the dense fibrillar compartment region of the nucleolus. {ECO:0000250}.
Interaction partners:
- Mitochondrial assembly of ribosomal large subunit protein 1
- Probable ATP-dependent RNA helicase DDX28
- Mitochondrial ribosome-associated GTPase 1
- Large ribosomal subunit protein mL62
- rRNA methyltransferase 3, mitochondrial
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL20m
- Delta-1-pyrroline-5-carboxylate synthase
- rRNA methyltransferase 2, mitochondrial
Sequence:
MVRCGCALLRKYGNFIDNLRIFTKGGSGGMGYPRLGGEGGRGGDVWVVAHKNMTLKQLKNKYPQKRFVAGGGANSRVSALQGSKGKDCEVPAPVGISVTDENGQVLGELNKEEDRVLVAKGGLGGKLHTNFLPLKGQKRIVHLDLKVIADVGLVGFPNAGKSSLLSRVSHATPVIADYAFTTLRPELGKIMYNDFKQISVADLPGLIEGAHMNKGMGHKFLKHLERTRQLLFVVDISGFQLSSVTPYRTAFETIILLTKELELYKEELQTKPALLAINKMDLPDAQVKLQELMKQLLSPEDFLHLFETKMIPEKALEFQHIVPISTVTGEGIAELKSCIRKALDEQDGKESDAHRSKQLLNLQSSS
Protein: Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) (Q90YJ9)
Organism: Gallus gallus (Chicken)
Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Interaction partners:
- MFS domain-containing protein.
- Glycerophosphocholine phosphodiesterase GPCPD1
- Ethanolamine kinase
- Phosphoethanolamine/phosphocholine phosphatase
- Hydroxyacyl-thioester dehydratase type 2.
- Solute carrier family 25 member 20
- LDL receptor related protein 4.
- Uncharacterized protein.
- Ig-like domain-containing protein.
Sequence:
MPDLEKDMQKKEKDSRSKDEPAVPKLPVPPLQQTLQMYLQCMKHLVPEEQFRKTKSIVEQFGVAGGLGESLQLILEERREETTNWVFNYWLDDMYLNNRLALPVNSSPAIIFARQNFKDVNDQLRFAANLISGVQDYKALLDSHALPVDFARGQLSGQPLCMKQYYGLFSSYRLPGHTKDTLVAQKSCVMPEPEHIIVACNNQLFVLDVGINFRRLSEGDLFTQLRKIAKMAENEEEMLPPIGLLTTDGRTEWAEARTILMKDSTNRDSLDMIERCICLVCLDGTSGVELNDTNMALQLLHGGGYHKNGANRWYDKPMQFVVGRDGVCGTVCEHSPFDGIVLVQCTEHLLKHMKESSKKLLRADSVSELPAPRRLRWKCSPEIQAHLASSAEKLQRIVKNLDFIAYKFVNYGKEFIKKQKTSPDAYIQVALQLAFYRCHRRLVPTYESASIRRFDEGRVDNIRSATAEAFAFVKAMIDDKPALSDSEKMQRFKDAIAAQTNYTILAITGMAIDNHLLGLREVAREHFKELPEIFTDETYLTSNRFILSTSQVPTPMEMFCCYGPVVPNGYGACYNPQPEHILFCISSFKDCKETSSDMLAKAVEESLLEIRDLCNKCSSSTAKSLAKQEEATQLRSDRKL