wanglab/gogpt-training-data huggingface dataset:
Protein: Pappalysin 2 (F6TFC9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XSSMLLNFSSPLVGISAVALRTSSQTSSSAPSNCIPEQNYEGKRNVLRNIIQINPCAQRPCGEQGRCAPLLLDHTDMVNCTSSSPGHMECAITCQRGYVLQTSSGQYLRNMQKEILLTCSSGHWDKDVICKRLDCGVPDSSLVNYANFSCLEGTDFLKQCSISCVPPAKLQGLNPWLTCLEDGLWSLPEVYCKLECEAPPVIPNANLLLPHFLEGNHDVGTICKYECKPGYYVKETSGSQGKNKFL
Protein: Carboxypeptidase (EC 3.4.16.-) (Q6AYS3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Beta-galactosidase
- Sialidase-1
- Cathepsin D
- Cathepsin B
- Sialidase-4
- Galactosidase, beta 1-like
Sequence:
MPRAALSPLLLLLLLSWASRDEAAPDQDEIDCLPGLAKQPSFRQYSGYLKASDSKHFHYWFVESQNDPKNSPVVLWLNGGPGCSSLDGLLTEHGPFLIQPDGVTLEYNPYSWNLIANMLYIESPAGVGFSYSDDKMYVTNDTEVAENNYQALKDFYHLFPEYKDNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWTSLQTHCCSQNKCNFYDNKDPDCVNNLQEVSRIVGKSGLNIYNLYAPCAGGVPGRDRSEDTLVVQDFGNIFTRLPLKRRFPEALLLRSGDKVRLDPPCTNTTAPSTYLNNPYVRKALHIPESLPRWDMCNLMVNLQYRRLYESMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKVKCCWGSWAGVLGEGEPGEESPVSKAALSKDGGSHWLSSFPVG
Protein: Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (IL-12 subunit p40) (Q6X0K9)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU281113}.
Interaction partners:
- Interleukin-12 subunit alpha
- Uncharacterized protein.
- Fibronectin type-III domain-containing protein.
- Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
- Interleukin-6
- Interleukin-10
- Interleukin-1
- Protein disulfide-isomerase
- Interleukin-4
- Interferon type B
Sequence:
MSHLLFALLSLLSFAALLEAQWKLRENVYVIESEWNDETPAKKVKLTCDTSDEALPVYWKKGTELKGTGKTLTTEVKEFPDAGNYTCLSAKTHEIISYSFFLITKVDSNGQMIRSILKSYKEPSKTFLKCEAKNYSGIFTCSWMTENESPSVKFTIRSLKGSQGDVTCSSPVARTDKSVTEYTAQCQKENYCPFAEEHQPTEMFLEVIDEVEYENYTSSFFIRDIIKPDPPQCQYASTNGTVTWTYPKTWSTPKSYFPLTFRVKVESTKKYKSKVYDADEQSIQIPKTGPKDKISVQARDRYYNSSWSEWSTLCR
Protein: RNA-binding protein Musashi homolog 2 (Musashi-2) (Q96DH6)
Organism: Homo sapiens (Human)
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Subcellular location: Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.
Interaction partners:
- Numb-like protein
- RNA-binding protein Musashi homolog 1
- Protein numb homolog
- Homeobox protein Hox-A9
- DAZ-associated protein 1
- Nuclear pore complex protein Nup98-Nup96
- Zinc finger CCCH domain-containing protein 14
- Transcription factor SOX-2
- Rho-related BTB domain-containing protein 2
Sequence:
MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH
Protein: Eukaryotic translation initiation factor 4 gamma 1 (C9J6B6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV
Protein: Probable pectate lyase 18 (EC 4.2.2.2) (Pectate lyase A10) (Q9C5M8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Berberine bridge enzyme-like 26
- GEM-like protein 5
- SKU5 similar 3
- Pectin lyase-like superfamily protein
- Pectinesterase/pectinesterase inhibitor 3
Sequence:
MKMQTKKLFITIVSFLLYAPLFLSSPVPDPESVVEEVHKSINASVAGRRKLGYLSCTTGNPIDDCWRCDPHWEQHRQRLADCAIGFGKNAIGGRDGRIYVVTDSGNDNPVSPKPGTLRHAVVQDEPLWIIFQRDMTIQLKEELIMNSFKTIDGRGASVHISGGPCITIQYVTNIIIHGIHIHDCKQGGNAMVRSSPRHFGWRTISDGDGVSIFGGSHVWVDHCSFSNCEDGLIDAIMGSTAITLSNNHMTHHDKVMLLGHSDTYSRDKNMQVTIAFNHFGEGLVQRMPRCRHGYFHVVNNDYTHWEMYAIGGSANPTINSQGNRFLAPNIRFSKEVTKHEDAPESEWKRWNWRSSGDLLLNGAFFTPSGGAASSSYAKASSLGAKPSSLVGPLTSTSGALNCRKGSRC
Protein: Iroquois 3 homeobox protein (Iroquois homeobox 3a) (Iroquois-class homeodomain protein IRX-3a) (Q90Z68)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Oligodendrocyte lineage transcription factor 2.
- FTO alpha-ketoglutarate-dependent dioxygenase.
- Homeobox protein Nkx-2.2a
- Homeobox domain-containing protein.
- NK6 homeobox 1.
- Paired box protein Pax-6
- Spalt-like transcription factor 4.
- Sonic hedgehog protein
Sequence:
MSFPQLGYQYIRPIYSQDRQGIGSARAGTDLSPSGALSNVLSTMYGSPFAAAQSYGAFLPYSNDLSIFNQLGAQYELKDSPGVQHPGFAHHHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRSRTDEEGNVYNSDHEGDDGDKREDEEEIDLENIDTENIENKDDLDEQDELHSDLKLDGRSDSEISDGYEDLQGPEQRLFKAMVKDGKEIHGDRAEHFHHHSHHHHLHHNSLEQANGEPVKINQAIINSPPSENNPPPAPKPKIWSLAETATTPDNPRKSPLMNGTSAASATQTIITPHRLLSCPVGKIQSWTNRGFTAHQLALLNSNHYLGLSNQASANGLALYSRQAEDRSQNSESTVTERSSALEAEKKLLKTAFHPVQRRPQNQLEAAMVLSALSSS
Protein: Serine/threonine-protein phosphatase 2 (EC 3.1.3.16) (P55799)
Organism: Escherichia coli (strain K12)
Function: Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates.
Interaction partners:
- Uncharacterized protein YgbA
Sequence:
MPSTRYQKINAHHYRHIWVVGDIHGEYQLLQSRLHQLSFFPKIDLLISVGDNIDRGPESLDVLRLLNQPWFTSVKGNHEAMALEAFETGDGNMWLASGGDWFFDLNDSEQQEAIDLLLKFHHLPHIIEITNDNIKYAIAHADYPGSEYLFGKEIAESELLWPVDRVQKSLNGELQQINGADYFIFGHMMFDNIQTFANQIYIDTGSPNSGRLSFYKIK
Protein: Centrosomal protein 112 (A0A8I6A7K4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEMGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRSERQRCALWIRKLCEPSGTGAGLMGRKNRNLYAKLLLHMLRRGVLEGPFTHRPEPGTLKVLPSYMSIYFDEPNSAQSKDSSPEKLPDWVMGELEPGERRLSDSWQLSCGEENALLLSASDAHREQYTGKLRMRSHSVSPTDREDRQHITSKICEVHPKKSPISLDDSDIEVRLNSWNLGLDMKTKMMEAKFSEEKLKLQKKHDAEVQKILERKNNELEELKILYKKKQTETEETVRKLEKKVQILIRDCQVIRETKENQITELKKICEQSTESLNNDWEKKLHSAVAEMEKEKFELQKHHTETIQELLEDTNVRLSKMEGDYMVQTQSTNHMIKDLEGRVQQLMGEAENSNLQRQKLTQEKLELERCYQITCSELQELKTRQNLLHTEKEHLVNDYEQNVKLLKTKYDSDINILRQEHALSTSKTSVVIEELEQNIRQLKQQVQESELQRKQQVKDQEDKFHMEKNHLKYIYEEKVHELKSELDKEKEDAQRKIHKFEEALKEKEEQLGRVTEVQRLQAQQADAALEEFKRQVEVTSEKVYSDMKEQMEKVEADLSRSKSLREKQSKEFLWQLEDARQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREVENLENQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREELINVNSHRKQQLVELGLLREEEKQRAARDHETAVKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETRSNQVRSAEKKLQHKELEAQEQMMYIRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQSRR
Protein: Exportin-T (Exportin(tRNA)) (tRNA exportin) (F8WDU6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU366037}. Nucleus {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
Interaction partners:
Sequence:
MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQRTYSDDHVKFFCFQVLEHQVKYKYSELTTVQQQLIRETLISWLQAQMLNPQPEKTFIRNKAAQVFALLFVTEYLTKWPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEEARRNTLIKDTMREQCIPNLVESWYQILQNYQFTNSEV
Protein: MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) (Q4G050)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
Interaction partners:
- Eukaryotic translation initiation factor 4E
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- MAP kinase-interacting serine/threonine-protein kinase 2
- Cyclic AMP-dependent transcription factor ATF-4
- Eukaryotic translation initiation factor 4E type 2
- Mitogen-activated protein kinase 14
Sequence:
MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPERGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEHEALAEGLCSMKLSPPSKSRLARRRALAHAGREANSCSTPAGL
Protein: Transmembrane protein (Q57VG2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPSTICHRRTSHKVAALLFAPRHRTQRTQSQFGSTTGPTSGAKTDFSGKDGSNSINLSSDTDEAKGNDWHGGGVPRENRSFHFDPNKLPDTIPGLERRELAARLEEQQRELAQKYQQSAADDLAKAIDLMRRAMPPEEFKRFLQDVEKAAAEGSKEAARISAMSPAQLYRYQRRQRRRQRVQLFAKTVMLFVSVFGCVFFLFFFFFFFH
Protein: Daunorubicin/doxorubicin resistance ATP-binding protein DrrA (EC 7.6.2.2) (P32010)
Organism: Streptomyces peucetius
Function: Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9006006}; Peripheral membrane protein {ECO:0000269|PubMed:9006006}; Cytoplasmic side {ECO:0000269|PubMed:9006006}.
Interaction partners:
Sequence:
MNTQPTRAIETSGLVKVYNGTRAVDGLDLNVPAGLVYGILGPNGAGKSTTIRMLATLLRPDGGTARVFGHDVTSEPDTVRRRISVTGQYASVDEGLTGTENLVMMGRLQGYSWARARERAAELIDGFGLGDARDRLLKTYSGGMRRRLDIAASIVVTPDLLFLDEPTTGLDPRSRNQVWDIVRALVDAGTTVLLTTQYLDEADQLADRIAVIDHGRVIAEGTTGELKSSLGSNVLRLRLHDAQSRAEAERLLSAELGVTIHRDSDPTALSARIDDPRQGMRALAELSRTHLEVRSFSLGQSSLDEVFLALTGHPADDRSTEEAAEEEKVA
Protein: Small archaeal modifier protein 1 (SAMP1) (Ubiquitin-like small archaeal modifier protein 1) (D4GUF6)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in molybdenum cofactor (MoCo) biosynthesis. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP1 C-terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by proteasomes.
Interaction partners:
- Probable molybdopterin synthase
- Molybdopterin molybdenumtransferase
- SAMP-activating enzyme E1
- Small archaeal modifier protein 3
- Probable cyclic pyranopterin monophosphate synthase
- Desampylase
- Small archaeal modifier protein 2
- TrkA-C domain protein
- TrkA-C domain protein
- Probable GTP 3',8-cyclase
Sequence:
MEWKLFADLAEVAGSRTVRVDVDGDATVGDALDALVGAHPALESRVFGDDGELYDHINVLRNGEAAALGEATAAGDELALFPPVSGG
Protein: Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (P0A8M0)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Methionine--tRNA ligase
- Arginine--tRNA ligase
- Leucine--tRNA ligase
- Isoleucine--tRNA ligase
- Proline--tRNA ligase
- Tyrosine--tRNA ligase
- Glutamine--tRNA ligase
- Glutamate--tRNA ligase
- Threonine--tRNA ligase
- Histidine--tRNA ligase
Sequence:
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKVVASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVSTPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNTSRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTDAVTILENCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
Protein: Peptidase M14 carboxypeptidase A domain-containing protein (Q22825)
Organism: Caenorhabditis elegans
Interaction partners:
- TIR domain-containing protein
Sequence:
MLPILLVFLFSALSQCSRLAEEEEQMLIRHFTKEGEVSTMDQLRDTIGPFRDPLNFSHMNYSTLTDHIHNLHRKFPNLTHIYSAGQSVQGRELWVLVVSRYPIEHRKLIPEFKYVANMHGNEVTGRVFLVSLAHTLLENYNSNLWIRQLVDSTRIHLMPSMNPDGYEHASEGDQAGVTGRQNANGKDLNRNFPSRFPNYFPTSEIQPETIAIMNWTRQIPFALSANLHGGTTLVNYPFDDFPTRTRQSHYAPSPDNALFVRLAYTYARGHERMWKKGPRCLDDDLNISVDPQNGIINGADWYIVSGGMQDWNYLNTNCFEVTVEMNCEKFPQTKKLRYLWEENKYALLKFIDLIHGAIHGLVIDADTGEGIVNATVSIDERAKIVVSYGEGEFWRLANMGKYDLTFDHSDYYPVTQTVHVTPQDRSPYIEVRLQRIIPRSRPVLIPTKSVPNKDEYNVDNSNNKDLRIVTMSSSVCHFSVFMIILSLASLFL
Protein: Rhamnose binding lectin STL2 (Q9IB52)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MLLVTLTGFTLLAAVCCTLPAAATRVVTCDNGENVQFLICDSGVIFIERALYGRTDGTTCREGRPANQLTNTQCSQTGTLEVLSQRCNGKQVCEVNTEVFRTSDPCVGIYKYLETTYTCIPATRSITCEGSDAQLECDEGTIQIYSANYGRRDQLVCSFKRPANQLANTNCLSQSITTSKVAERCNGKIQCDVPASNSLYGDPCVGTYKYLEVAYTCG
Protein: Ectonucleotide pyrophosphatase/phosphodiesterase 2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor (EC 3.1.4.39)) (Q6PGY9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Glycerophosphodiester phosphodiesterase domain-containing 3b.
- Glycerophosphodiester phosphodiesterase domain-containing 1
- Glycerophosphodiester phosphodiesterase domain containing 3
- Lysophosphatidic acid receptor 1
- Glycerophosphocholine cholinephosphodiesterase ENPP6
- lysoplasmalogenase
- Lysophosphatidylcholine acyltransferase 4
- Phospholipid phosphatase 3
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 3
Sequence:
MLQLKWVFSVMWLFSRLTVCKTYVVRRSGKAASPDESLSKSFSDQPFTSLAGSCKKRCFELVEADPPNCRCDNLCKTYNMCCSDFDDHCLKTAGGFECSKERCGENRNEQHACHCSEDCMAKGDCCTNYRSLCKGDVPWLQEECEEIKNHECPAGFVRPPVIMLSVDGFRASYMKRGGTVIPNIEKLRSCGTHAPYMRPMYPTKTYPNLYTITTGLYPESHGIVGNSIHDPSFDANFNFRGKEKLNHRWWGGQPIWITAMKQGVKAGSFFWPVAIPMERRVLTMLQWLHLPDAERPYLYAMHSEQLDSYGHKLGPHSTELNSALRDVDKVIGQLMNGLKQMKLHRCINIILVGDHGMEEAHCDKTEFLSSYMSNTEDLILIPGSLGRIRARNPNNSKFDAKAVVANLTCKKPDQHFKPYLKQHLPKRLHYANNDRIEEIHLMVERKWHIARKIMKTKRNHEKCGFAGDHGYDNKINSMQTIFLGYGPAFKFKTKIPPFENIELYNIMCDLLGLKPAPNNGTHGSLNQLLRTPVYIPNMPEEVTKPNPAGPVIAINDDLGCTCEDKNKVDELNQRLRQVIDDNKNLPYGRPAVMFRTKYCILHHTDYISGYSEALHMPLWTSYTVSKQVDFTPLTDALSNCIRPDSRVPTAYSQSCSNYRTEKQISYSFLYPPQLSSTQEARYDAVLITNTVPMYAAFKRVWSYFQKSLVKRYASEKNGVNVVTGPIFDYDYNGLRDSAETIKQFVSGSVQIPTHYFVVVTSCLDYTQTVDSCVGPLSVFSFILPHRSDNEETCNSSEDESKWVEELMKTHTARLRDVELLTGLDFYRRTSRTYEEILALKTYLHTYESEI
Protein: Sulfate/thiosulfate import ATP-binding protein CysA (EC 7.3.2.3) (Sulfate-transporting ATPase) (P16676)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01701}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01701}.
Interaction partners:
- Thiosulfate-binding protein
- Sulfate adenylyltransferase subunit 2
- Sulfate transport system permease protein CysT
- Phosphoadenosine 5'-phosphosulfate reductase
- Sulfate adenylyltransferase subunit 1
- Sulfate transport system permease protein CysW
- Sulfite reductase hemoprotein beta-component
- Sulfate-binding protein
- Adenylyl-sulfate kinase
- Sulfite reductase flavoprotein alpha-component
Sequence:
MSIEIANIKKSFGRTQVLNDISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQTSGHIRFHGTDVSRLHARDRKVGFVFQHYALFRHMTVFDNIAFGLTVLPRRERPNAAAIKAKVTKLLEMVQLAHLADRYPAQLSGGQKQRVALARALAVEPQILLLDEPFGALDAQVRKELRRWLRQLHEELKFTSVFVTHDQEEATEVADRVVVMSQGNIEQADAPDQVWREPATRFVLEFMGEVNRLQGTIRGGQFHVGAHRWPLGYTPAYQGPVDLFLRPWEVDISRRTSLDSPLPVQVLEASPKGHYTQLVVQPLGWYNEPLTVVMHGDDAPQRGERLFVGLQHARLYNGDERIETRDEELALAQSA
Protein: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Q2TWM0)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU361237}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU361237}; Matrix side {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU361237}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Uncharacterized protein
- CoA-binding domain-containing protein
- Succinate--CoA ligase subunit alpha, mitochondrial
- fumarate hydratase
- N-acetyltransferase domain-containing protein
- Succinate--CoA ligase subunit beta, mitochondrial
- NADH-quinone oxidoreductase subunit D domain-containing protein
- Succinate--CoA ligase subunit beta, mitochondrial
- 4Fe-4S ferredoxin-type domain-containing protein
Sequence:
MAALRSTSRLVASSKPLFRPAVFARSYATVDAAAQDPNPSETPRTKTFHIYRWNPDQPTEKPKMQSYSLDLNKTGPMMLDALIRIKNEMDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPTDTAKESRIYPLPHTYVVKDLVPDLTQFYKQYKSIKPYLQRETKTEDGLEYRQSPEERKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAILLQSYRWLADSRDEKTAERKHALDNSMSVYRCHTILNCSRTCPKGLNPARAIAEIKKLMAAH
Protein: Capsid polyprotein (ORF3 protein) (EC 3.4.-.-) [Cleaved into: Capsid protein] (P85500)
Organism: Pseudomonas phage PAJU2
Function: The C-terminus contains the capsid protein. The N-terminal region may act as a prohead protease.
Subcellular location: [Capsid protein]: Virion {ECO:0000269|PubMed:19010363}.
Interaction partners:
Sequence:
MKTNRAYSTLEVKALDDEKRVITGIASTPSPDRMQDVVEPKGAQFKLPIPFLWQHNHDEPIGHVTEAKVTQKGIEVSVQLTQVEEPGKLKDRLDEAWQSIKSGLVRGLSIGFSAKEFEQIPGSWGLRFLSWEWFELSAVTIPANAEATITSVKSIDREQRAALGIKSVPVVRVTPAGASAIKTKTIKVPKPQEGNDMKTTAEQIAEFEATRVTKAAEMEAIMTKAAEAGETLDAEQSEQFDTLEAEIAAIDKHIGRLKQMQKAQAANAKPVTEEAGAQRMANVKALDFKEVQVRAKNTQKLEPGIAFARAAKCLALGHLEHRDAIGIAKSLYDGQDSIIAATQRLVTKAAVAAATTSDATWAGPLVGDETSVFADFVEYLRPQTILGRFGTNGIPSLRRVPFRVPLIGQTSGGDGYWVGEGQAKPLTKFDFERKTLEPLKVANIAVATMEVIRDSSPSADVIIRDQLAAALRERLDIDFIDPAKAAVAGVSPASILNGVAGIPSSGNTADDVRADIRALFNAFIAANNAPTSGVWLMPATTALALSLMQNPLGQAEFPGISMTGGTLFGLPVIVSEYIPTASAGAVVALVNASDIYLGDEGGVDLSMSTEASLQMDNAPDNPTTASTVLVSLWQRNLVGFRAERAINWARRRASAVAYLTGVNWGAA
Protein: Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) (Q9HAZ2)
Organism: Homo sapiens (Human)
Function: Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:19049980}. Cytoplasm {ECO:0000269|PubMed:22939622}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- CCAAT/enhancer-binding protein beta
- Zinc finger protein 516
- C-terminal-binding protein 1
- Histone-lysine N-methyltransferase EHMT1
- Mitochondrial brown fat uncoupling protein 1
- C-terminal-binding protein 2
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- Lipid transferase CIDEA
Sequence:
MRSKARARKLAKSDGDVVNNMYEPNRDLLASHSAEDEAEDSAMSPIPVGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIPIPADFELRESSIPGAGLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPMMDKAKPSPSLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASLAVGFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEALKHTLCRQAKNQAYAMMLSLSEDTPLHTPSQGSLDAWLKVTGATSESGAFHPINHL
Protein: Conserved oligomeric Golgi complex subunit 7 (Component of oligomeric Golgi complex 7) (A0A0S2Z604)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}.
Interaction partners:
Sequence:
MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKLQLFIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVISAKLTGQQRPAPSPGHHRGHHAECEL
Protein: Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) (P48760)
Organism: Mus musculus (Mouse)
Function: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5-formyltetrahydrofolate are the best substrates. Folic acid and 5-methyltetrahydrofolate can also act as substrates.
Subcellular location: [Isoform 1]: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q05932}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q05932}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q05932}.
Interaction partners:
- Dihydrofolate reductase
- Gamma-glutamyl hydrolase
- Thymidylate synthase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- Serine hydroxymethyltransferase, cytosolic
- GTP cyclohydrolase 1
- Bifunctional purine biosynthesis protein ATIC
- Serine hydroxymethyltransferase, mitochondrial
- Methylenetetrahydrofolate reductase
Sequence:
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNASYLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRNYGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGAHQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVWPGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRDSAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEKQASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSLPRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ