wanglab/gogpt-training-data huggingface dataset:
Protein: Baeyer-Villiger oxidase mdpL (EC 1.-.-.-) (Monodictyphenone synthesis protein L) (C8VQ61)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Baeyer-Villiger oxidase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that catalyzes the oxidation of emodinanthrone to emodin (By similarity). Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC mdpJ, mdpK and mdpL. These enzymes with xptA, xptB and xptC are also proposed to be involved in the synthesis of shamixanthone from emodin. Especially, direct reduction of emodin by the short chain dehydrogenase mdpC followed by dehydration catalyzed by the scytalone dehydratase-like protein mdpB gives loss of oxygen and formation of chrysophanol intermediate in two simple steps.
Interaction partners:
Sequence:
MSSSINILSTKLGQNIYAQTPPSQTLTLTNHLLQKNHDTLHIFFRNLNGHNHLVHNLLTRLVLGATPEQLQTAYDDDLPTQRAMPPLVPSIVERLSDNSYFESQITQIDQYTNFLRFFEAEIDRRDSWKDVVIEYVFSRSPIAEKILPLMYDGAFHSIIHLGLGVEFEQPGIIAEALAQAAAHDSFGTDYFFLTAEKRAAGRNEEGETLVNLLQKIRDTPKLVEAGRVQGLIGTMKMRKSILVNAADEIIDIASRFKVTEETLARKTAEMLNLCAYLAGASQRTKDGYEPKIDFFFMHCVTSSIFFSILGRQDWISMRDRVRLVEWKGRLDLMWYALCGVPELDFEFVRTYRGERTGTMSWKELFAIVNEQHDDGHVAKFVRALKNGQEVCGQFEDGEEFMVKGDMWLRIARMAYETTIETNMQNRWVVMAGMDGAWKDFKVQSSD
Protein: RE01954p (Relative of woc, isoform A) (Q5U156)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTRVTRSEISLDMEFWVEELSPAQLAYYEKITNEHNAVKGALKNAVSANEGKELFNGQVFQAYSFKGKVLQELKEATLPKKPPKPTDSPSTPAAQSGGTGRGRGRPPRQPSNIAYLESSDEGDDDMPLAKRLALSAGKKAVAVANASSSFTPKSSKKAASAASGGSSSPVPKSSGKLFKESKPDIESPPKNYRPAEVNSVGGLVVGSTDESKDSKDGKDGKDNKMQGKTYPSLVVLAKPFLKIKDMAATRSKLDSKVKLVLMLTPNKFCEWLLQEGLLRAQQHCINHRNNELKLGIYSDVTKFPYTGGYVWISECCPYRFVSVFNNSIFEGAQHPPTFLLKLIYHWACQTSIQNVVQWVKVDSVYIKGIYTWLRAICTLAVHQKCKKLGGPGKFVEVGVISLGTTSQDGSQRQVKVEVLGVYDYAEKSIRLRAVEPITDGDRNYKKRFQAILEPLSRWVHKDSTICIDLTVDKITLFSMGFKNIVQAAATDNTAKHNNSAVMEYLRRIVPRMFQNTLSLLSRQMIQQFLDELVWRESFGTYALQAFNNIIIHIAEQTRVTTNETITQRLYQVATNPFKDWSILPANYKETPANAAPKRLKKPINDADYVVSNKIPKKEKDRDIASSGVKRGRPPNALGTPPPQLPIKKGPGRPPGSTNQTKGDRATTSSSKSLSKSLIAKGLGKKPKEKDEKIPMVIKKEEDDLRGLEELYYGISDGTDEYHEIFPYSTPRTVHNELAKTVECPICLNGDSFDSNEKLQTHLVSHISPEGKQHQFQCLFCLEKHPTESVLAKHNQIMHPTETKTEGSPSYYCLICQQRHNSLHLLTAHLQKVHSTLELPYWCHSCGYRSSSHRDLVRHFYDDHKHQNFLQCPYCLDIFYFSKLGVVNQLRIEHYFMHLDEHINKRDPSLRCQKCSLSFLEKGDLKQHAVQHHVSMTKTNRPVRLLLNNSMLIPPPKIRTHHREQPPFSTYKRPVFFAFLEGKTCAECNTDFASEETHYTGWLHCVKCNYQTCCERAQFRHGVECNGNFVDAMEVNMPQEMHCICGFATGNGNKMAQHLANCGLSTCYPSLEAASENAVKRNMLDMLGLVRRDGETSGEGADISETADDVADQSSDMLPPQEDHHLQQHHQQVGHQQQMQGQPNEPQAELQQEYLSAPVEHEPVQNMPVHQSMPVQQTGPIQFGEMEAAPVLLDTQQQVQPTPDYAQVSVVQQHQQQQPYGLSNYGQSSLATDIDMPLIGELSEPNAPPTPQFLGEVHTPMFDAVAAAEQQHYHAQHHHHPQ
Protein: Large ribosomal subunit protein eL29z (60S ribosomal protein L29-1) (Q9M7X7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL39z/eL39x
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein eL39y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein eS6y
- Large ribosomal subunit protein eL13x
- Large ribosomal subunit protein uL10y
- Large ribosomal subunit protein uL23z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
Sequence:
MAKSKNHTAHNQSAKAHKNGIKKPRRHRHTPTRGMDPKFLRNQRYARKHNVKAGENASAEE
Protein: WD_REPEATS_REGION domain-containing protein (O45087)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Dynein light intermediate chain
- Dynein light chain roadblock
- Dynein heavy chain, cytoplasmic
- Cytoplasmic dynein 2 heavy chain 1
- Dynactin subunit 1
- Probable dynactin subunit 2
- DYnein Light chain
- Tctex1 domain-containing protein 2
- DYnein Light chain
- Dynein light chain 1
Sequence:
MSELRKLELERKKQKLAELKSQRKREEDARVQNLLRSTNENGTTQNGTSRQTLSSNEVEDILRQVGISTEPTVREESPAPPPGSHSDNHVDPSASHPRISNLLSVDLEFSSVQTACTDNKDSAIYSKGTQTDDERISVGEFSLGSQEFDYDDDMIMPMDHGQFRGRAHSHDQDSPLPYNEEIAKLLGQTKQGDKGLTRQETEEKKTQTVQIVPPLSDEEKYRLTLDPEFLDSFNRSCKVISRALNEEIDICINYTKDPYEKAIASDDLLHLAQVYQDETWTAKRLVTGMAFSEHYPDLLAVSYGPCDIPNEPPGVIVVWNTKSKRMTAEFIVYCQSEIQSVAFARFHAHLLLAGCESGQICVWDNRLTSRKLPINRSPLTTQAHTYTVSCLAVVGTKNAHNFVSLSRDGRICSWNVDNLTQPVDGKELMTKEGKAASATRMSFPIGEMQTFVVGTDTGEILAASRNGADPAVIKTDVCYKGHSGTLTGIEFHRASGVVDFSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVFASIDADGNIFVWNLNEDVEGPVARLRAGAEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVRESLYVLKSEEWNRFARVLSDMKQSNEEAENYNM
Protein: PHD finger protein EHD3 (Proetin EARLY HEADING 3) (Q6ZJM9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor involved in the regulation of floral induction under long day (LD) conditions. Promotes photoperiodic flowering by repressing GHD7, a major floral repressor. Seems to function independently of HD1.
Subcellular location: Nucleus {ECO:0000269|PubMed:21284756, ECO:0000269|PubMed:24420930}.
Interaction partners:
- Os03g0207900 protein
- Histone H4
- Histone H4
- Os11g0146500 protein
- Os12g0143200 protein
- Os11g0145700 protein
- Histone-lysine N-methyltransferase TRX1
- Os02g0708600 protein
- Os02g0708500 protein
- Os02g0717600 protein
Sequence:
MGSQNRPPPPRKRQPPPPEDHLVTYKRRRSKETQPLPLMANGANSKKDAKAQHWISWRDTLHGFLQSPAISQGGGIQTCIRHALQHNPCLLTNGVVVHTEFKGNPAHSQGEEAKVQHPNGAAGGKVVSADAAIQDAAAAASSEANKAMCNNALFDILVSQKFALLCHLLLGTFHVNKPGDVIDLEKIDAKMRNGDYAHNPALFDDDIQQMWEKFEQVGQEMTGLASNLSTISRVSYQKQASGFSEAEVAEHRIEEISLPGAVHVVTKESTTTVQLAPCDSSHSTIPKRTVPPGRDLCPCDGCGTKVDVEEGLICDECDTMYHFACVKLLNPDIKQVPAIWHCSTCSFKKKELAADTTNNVAHDCLHGGNCVLCDQLELVKTEEEDPKLPIKIELAEEREGSSVSSMGEDNEPDLSTTALSNLCKHCGTCEDDDKRFMVCGHPYCVYKFYHIRCLKTSQLAIEQQKKLGCWYCPSCLCRGCFQDKDDDQIVMCDGCDEGYHIYCMRPARNTIPKGKWYCTFCKIRRAAEGMHKYEDSVLKIHGNSKHACNVNQSKDSEGDGTEK
Protein: Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) (O88531)
Organism: Mus musculus (Mouse)
Function: Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
Subcellular location: Lysosome {ECO:0000269|PubMed:19941651, ECO:0000269|PubMed:9685319}. Secreted {ECO:0000269|PubMed:9685319}.
Interaction partners:
- Lysosomal thioesterase PPT2
- Battenin
- Ceroid-lipofuscinosis, neuronal 6
- Bis
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- Protein CLN8
- Tripeptidyl-peptidase 1
- Long-chain-fatty-acid--CoA ligase ACSBG2
- Long-chain-fatty-acid--CoA ligase 4
- Major facilitator superfamily domain-containing protein 8
Sequence:
MASSCSRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDSCCNPMSMGVIKKMVEKEIPGIYVLSLEIGKNMMEDVENSFFLNVNVQVNMVCQILEKDPKLQQGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKLVQERLVQAQYWHDPIKESVYRNYSIFLADINQERCVNESYKKNLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQESTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK
Protein: Putative glutathione S-transferase alpha-3 (EC 2.5.1.18) (GST class-alpha 3) (Q54VI4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Interaction partners:
- Glutathione synthetase
- Putative glutathione S-transferase alpha-5
- Glutathione reductase
- Glutathione S-transferase
- Glutathione S-transferase
- Glutathione transferase
- Uncharacterized protein
- Putative glutathione S-transferase alpha-1
- Putative glutathione S-transferase alpha-4
- Putative glutathione S-transferase alpha-2
Sequence:
MTKPQLSYFKVRALGQFPRVLLSYLSIDYDNNYIDKIDENIIDDLKYGQLPLYTDSNGFKLVQSMAISKYIASQHDFVGKTPEEKALVDETLAAVNIDVFTFIIRVFRGVEEKEKIQEIIIPRFFAKWNQILGEKKYLAGGNSYTLADLYVYVAYEYIGYVLPFAADLLYNGKFPHLDSLKEHFESNKGVAEYLKNRPITERKI
Protein: Malate oxidoreductase (EC 1.1.1.38) (Q9CGB2)
Organism: Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Interaction partners:
Sequence:
MVDFNKVLDLHELHTGVLDIQADIDVKKPSDLAEAYTPGVAELSKLIQSDPEAKRKYTMSGKLVAVVTDGTAVLGLGNMGPAGGLPIVEGKALLYKELAGVDAIPIAVEQIGAEKIIETIKNISQSFAGIHLEDISAPQCFEIEERLSKNLNIPVYHDDQAGTAIVVLAGLMNAAKLVNKKLEDLKIVINGVGAAGVATGRLFAEVGIKNVTLIDIEGKVNDKVKSYNRYQLELAKRFNQVAGTTLDEVIDGQDVFIGLSDAKVLTGTQVERMAKDAIIFALANPVPEILPEEALKHGAAVVATGSNQWPNQVNNVLVFPGLFKGLLSANVQHVDYKLQANIATAIADVIKNPDRNHIVPGVFDAGVVESVTKAVKDSAK
Protein: Cyclin-B1-2 (Cyc1b-At) (Cyclin-1b) (G2/mitotic-specific cyclin-B1-2) (CycB1;2) (Q39067)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May induce mitotic cell division.
Interaction partners:
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B2-1
- Wee1-like protein kinase
- Cyclin-dependent kinases regulatory subunit 1
- Cell division cycle 20.1, cofactor of APC complex
- Cyclin-dependent kinases regulatory subunit 2
- Protein FIZZY-RELATED 2
Sequence:
MATRANVPEQVRGAPLVDGLKIQNKNGAVKSRRALGDIGNLVSVPGVQGGKAQPPINRPITRSFRAQLLANAQLERKPINGDNKVPALGPKRQPLAARNPEAQRAVQKKNLVVKQQTKPVEVIETKKEVTKKEVAMSPKNKKVTYSSVLSARSKAACGIVNKPKIIDIDESDKDNHLAAVEYVDDMYSFYKEVEKESQPKMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEWYLTVPTQYVFLVRFIKASMSDPEMENMVHFLAELGMMHYDTLTFCPSMLAASAVYTARCSLNKSPAWTDTLQFHTGYTESEIMDCSKLLAFLHSRCGESRLRAVYKKYSKAENGGVAMVSPAKSLLSAAADWKKPVSS
Protein: Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (G5E9G0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Protein: Mitochondrial division protein fszB (Q9GPZ7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probably involved in mitochondrion division process. Binds to and hydrolyzes GTP (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14665465}. Note=Locates to a submitochondrial body usually located at one end of the organelle.
Interaction partners:
- Dynamin-B
- Dynamin-A
Sequence:
MTILNRFCRTILLTNLELTNCGIRKNNSYKCRSFTHTINIDTNHIVPIHTQSNITLELFQPKISVVGVGGGGGNAVNHMISQSLEGVEFFVCNTDSQDLIKSNSINKIQLGPQLTKGHGAGANPEKGRLAAEESKNKIIQTFKDTDLLFLAAGMGGGTGTGSSPIIAKTIKEFKKETIIVGVVTVPFNFEGKRKEIIAKKGLEELSKYVDTLVVISNQNLLDASKSDIQLEQAFLMVDEILHTGIRSIANIINVPGMINLDYSDVVNILKNRKGLSRIGFGEASGEDRAYKAVHKAIKNPLIEIDDQKFTGLLVNISGGNDITLNEISKTINYLQQNADPDVQVFVGHTVDNSLLGKIRISCLFVH
Protein: Squalene synthase (SQS) (SS) (EC 2.5.1.21) (Q6IAX1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
Protein: Actin-binding lim zn-finger protein limatin involved in axon guidance (Q95QM5)
Organism: Caenorhabditis elegans
Interaction partners:
- UNC-34
- Ras-related protein ced-10
- Actin
- Abnormal cell migration protein 10
- Netrin receptor unc-40
- CRAL-TRIO domain-containing protein
- Netrin unc-6
- Rac-like GTPase
- Wiskott-Aldrich syndrome protein family member
- Netrin receptor unc-5
Sequence:
MKFSRPVLSVNHLILGKKCDVCRKKCSGDVLKANDKYFHINCFQCKKCGRNLGETGFYTTPENAYLCPDDFRAVSKEITVKTTTQQAHASSSSAATPKSPEKSNGTTDVSSSGAANATLQQISPLGSPTTCAACDQALHSGQVLLALGLSWHVYCFKCSECSAVLHGEYMSHHGKPLCLRDYNEKFGVKCYECEKFIAGKVLQAGGYKFHPTCARCSRCGSHFGDGEEMYMQGDEIWHPSCEHARTTENIAPTGRAATLSRNEPKYQSTFGQHQAYMYLLPEVEQTYLRHPVMNAKEPNAPQYHVPQGPIKIRKSRMSMLKTGMQRLTEDLEKNIPRPKSPHMDNEEPIELAHYPAAHVPDPDTLPAIEREDFPAPQFPYAVEELKRRLSTSSVENEISDDEYSESDKVDEDKLRKTVETLEKYNDSSIAHVIRQNIEDSHKKQRLPLHWDPRNASRTPSGKKMPHLKFRYDVPINASPSRHLNRPRPWVVWQGGERDQGNNTLPCFHIPEDSRANTLRAATLPTEFGQNLSLENLDTTISSHYSEHSTTESGTAGGPRSAGGAVLRSSLPDMSKPAKQYDLLFLQTTNSDLPEDVDRQHLERHLPRDQFEEIFKMSLIEFYKLPEWKRINLKRKHKLF
Protein: Uncharacterized protein (F4I543)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDFRSRRVQFLLFAIGLIALSMTAEKCRELVGQEAASKSGQFTFLNCFDMSSGTLACAVKEGVKLYFYNIRSIHVEKARNVAIEKALHEALDNGMLAKEAAKEGQRAGEKAAKLATRQAKRIIGPIVAAGWDFFEALYFGGTLTEGFLRGTGTMVGAYSGGYVGEQRFGRFGYLVGSTLGNWVGARVGLMVYDVVNGVNFFYETYQSGEIYEDQSTNESPEDRSTYESREDPSTYESPEDRSTYEIREDQSTYESPEEDQSTYETSNYEL
Protein: Vegetative storage protein 2 (O82122)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as somatic storage protein during early seedling development.
Interaction partners:
- Defensin-like protein 16
- Transcription factor MYC2
- Ethylene-responsive transcription factor ERF094
- Lipoxygenase 2, chloroplastic
- Coronatine-insensitive protein 1
- Thionin-2.1
- Cystine lyase CORI3
- Regulatory protein NPR1
- 12-oxophytodienoate reductase 3
- Protein TIFY 10A
Sequence:
MKILSLSLLLLLAATVSASVPGLIELVDSKTIFGNVAELLEKEKLSINYANCRSWHLGVETSNIIDFDTVPANCKDYVEDYLITSKQYQYDSKTVCKEAYFYAKGLALKNDTVNVWIFDLDDTLLSSIPYYAKYGYGTEKTDPGAYWLWLGTGASTPGLPEALHLYQNIIELGIEPIILSDRWKLWKNVTLDNLEAAGVTYWKHLILKPNGSNLRQVVYKSKVRKSLVKKGYNIVGNIGDQWADLVEDTPGRVFKLPNPLYYVPS
Protein: Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) (Q8N1M1)
Organism: Homo sapiens (Human)
Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTVQMGLSGSDFPDEEWLWDYEKHGHRHSMIRRVKRFLSAHEHPSSPRRRSYRRQTSDSSMFLPRDDLSPARDLLDVPSRNPPRASPTWKKSCFPEGSPTLHFSMGELSTIRETSQTSTLQSLTPQSSVRTSPIKMPLVPEVLITAAEAPVPTSGGYHHDSATSILSSEFTGVQPSKTEQQQGPMGSILSPSEKETPPGGPSPQTVSASAEENIFNCEEDPGDTFLKRWSLPGFLGSSHTSLGNLSPDPMSSQPALLIDTETSSEISGINIVAGSRVSSDMLYLMENLDTKETDIIELNKETEESPK
Protein: Signal transducer and activator of transcription (Q66HB2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNNLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRVHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHIKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSNYSDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKARLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETAMNSPYSAE
Protein: ATP synthase subunit gamma, mitochondrial (Q38CM0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
- ATP synthase subunit beta
- ATP synthase, epsilon chain, putative
- ATPase subunit 9, putative
- ATP synthase alpha chain
- Uncharacterized protein
- ATPase subunit 9, putative
- ATPase subunit 9, putative
- ATP synthase delta chain
- Uncharacterized protein
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MSGKLRLYKEKLEGYNRFYSIVKTIKMVTLAKYRAAQGRIRTRDFSLRYTELAFSKPQASRDAVAAAKNALVYIPITTNRGSCGALNSNIVRCIDSVVSSKMVLMPVGKRGIDSFSKLFPDEFRYGIINDMKESMHFGYATFVIENAYEVSKDADRYQVIFNRFVSAGVQRNAVYNIPSYEKWKEDLADAGSSDNQKNRYLFANALQNEEEQLIRDFFDFHAALAVLNAVGENELSEQAARLVAVEGQLTNISSLQQRTSSLYNKTRQFGITAALIEILSAMSSLEGNAMKGVRRNKFWEGAVTK
Protein: SR-CI (Q5ELR7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSIDLDNGSINYRQRNMVRFRCNRGYTLQGTVMQTCDRYGRLRGEKPFCASRGCAKPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTATTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTTMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLRKQRKRNSMDDQPLCDSDNDDVDYFEEMGVDIRHRTDL
Protein: DNA mismatch repair protein HSM3 (Enhanced spontaneous mutability protein 3) (P38348)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 26S proteasome regulatory subunit 7 homolog
- Probable 26S proteasome regulatory subunit p28
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit RPN14
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome subunit RPT4
- 26S proteasome regulatory subunit RPN1
- Probable 26S proteasome regulatory subunit p27
Sequence:
MSEKETNYVENLLTQLENELNEDNLPEDINTLLRKCSLNLVTVVSLPDMDVKPLLATIKRFLTSNVSYDSLNYDYLLDVVDKLVPMADFDDVLEVYSAEDLVKALRSEIDPLKVAACRVIENSQPKGLFATSNIIDILLDILFDEKVENDKLITAIEKALERLSTDELIRRRLFDNNLPYLVSVKGRMETVSFVRLIDFLTIEFQFISGPEFKDIIFCFTKEEILKSVEDILVFIELVNYYTKFLLEIRNQDKYWALRHVKKILPVFAQLFEDTENYPDVRAFSTNCLLQLFAEVSRIEEDEYSLFKTMDKDSLKIGSEAKLITEWLELINPQYLVKYHKDVVENYFHVSGYSIGMLRNLSADEECFNAIRNKFSAEIVLRLPYLEQMQVVETLTRYEYTSKFLLNEMPKVMGSLIGDGSAGAIIDLETVHYRNSALRNLLDKGEEKLSVWYEPLLREYSKAVNGKNYSTGSETKIADCR
Protein: L-ascorbate oxidase (EC 1.10.3.3) (O65670)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Berberine bridge enzyme-like 22
- AT hook motif-containing protein
- RING-type E3 ubiquitin transferase
- T23E23.1
- At1g12450
- Serine carboxypeptidase-like 3
- Very-long-chain 3-oxoacyl-CoA reductase-like protein At1g24470
- Calcium-transporting ATPase 2, plasma membrane-type
Sequence:
MMRPKRSSDTVHVFNLMVLCFIALFFSSVLCQGKIRRFKWEVKYEFKSPDCFEKLVITINGKFPGPTIKAQQGDTIVVELKNSFMTENVAVHWHGIRQIGTPWFDGVEGVTQCPILPGEVFIYQFVVDRPGTYMYHSHYGMQRESGLIGMIQVSPPATEPEPFTYDYDRNFLLTDWYHKSMSEKATGLASIPFKWVGEPQSLMIQGRGRFNCSNNLTTPPSLVSGVCNVSNADCSRFILTVIPGKTYRLRIGSLTALSALSFQIEGHNLTVVEADGHYVEPFTVKNLFVYSGETYSVLLKADQNPRRNYWITSSIVSRPATTPPATAVLNYYPNHPRRRPPTSESSNIVPEWNDTRSRLAQSLAIKARRGFIHALPENSDKVIVLLNTQNEVNGYRRWSVNNVSYHHPKTPYLIALKQNLTNAFDWRFTAPENYDSRNYDIFAKPLNANATTSDGIYRLRFNSTVDVILQNANTMNANNSETHPWHLHGHDFWVLGYGEGKFNESEDPKRYNRVDPIKKNTVAVQPFGWTALRFRADNPGVWSFHCHIESHFFMGMGIVFESGIDKVSSLPSSIMGCGQTKR
Protein: Transmembrane protein 208 (Q38FE8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- Autophagy-related protein 9
Sequence:
MAKDTAKKNMRGNAVRMQVFSLITLTVNVICFLVSFWRQSSFPGFGSLAALAFWAGQEYASLALLKHFARPVFNAEGELLDCPDASDPKELGYYSLAQDVLWVCWVVQVLCFLFHWGFMVLYLPVPVMGLYKLWGIIGPLLTPAQPAAGEGCGFAPGGLSRAERRKMELQQRKKRV
Protein: Gibberellin 3-beta-dioxygenase 1 (EC 1.14.11.15) (GA 3-oxidase 1) (Gibberellin 3 beta-hydroxylase 1) (O24648)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Converts the inactive gibberellin (GA) precursors GA9 and GA20 in the bioactives gibberellins GA4 and GA1. Has a small activity on GA29, producing GA8. Unable to convert GA20 to GA5, GA5 to GA3 or GA12 to GA14. Involved in the production of bioactive GA for vegetative growth and development, but not for the 3-beta-hydroxylation of GA in developing seeds.
Interaction partners:
Sequence:
MPSLSEAYRAHPVHVNHKHPDFNSLQELPESYNWTHLDDHTLIDSNNIMKESTTTVPVIDLNDPNASKLIGLACKTWGVYQVMNHGIPLSLLEDIQWLGQTLFSLPSHQKHKATRSPDGVSGYGIARISSFFPKLMWYEGFTIVGSPLDHFRELWPQDYTRFCDIVVQYDETMKKLAGTLMCLMLDSLGITKEDIKWAGSKAQFEKACAALQLNSYPSCPDPDHAMGLAPHTDSTFLTILSQNDISGLQVNREGSGWITVPPLQGGLVVNVGDLFHILSNGLYPSVLHRVLVNRTRQRFSVAYLYGPPSNVEICPHAKLIGPTKPPLYRSVTWNEYLGTKAKHFNKALSSVRLCTPINGLFDVNDSNKNSVQVG
Protein: FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) (Q96M96)
Organism: Homo sapiens (Human)
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- Myotubularin-related protein 13
- SH3 domain and tetratricopeptide repeat-containing protein 2
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
Sequence:
MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
Protein: NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 4L) (NADH-plastoquinone oxidoreductase subunit 4L) (P26289)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01456}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01456}.
Interaction partners:
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- Photosystem I iron-sulfur center
- NAD
- NAD
Sequence:
MILEHVLVLSAYLFLIGLYGLITSRNMVRALMCLELILNAVNMNFVTFSDFFDNSQLKGEIFCIFVIAIAAAEAAIGLAIVSSIYRNRKSIRINQSTLLNK