wanglab/gogpt-training-data huggingface dataset:
Protein: LD23779p (Tsc1) (Q9VCC9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- TBC1 domain family member 7
- Gigas, isoform A
- GTP-binding protein Rheb homolog
- RAC serine/threonine-protein kinase
- Serine/threonine-protein kinase mTor
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Raptor, isoform B
- Ribosomal protein S6 kinase
- Inhibitor of nuclear factor kappa-B kinase subunit beta
Sequence:
MVIEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGYIFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCIITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIAYLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSLPVLLPETSNEDGSYAYPMTPGYSRMTSNTSNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWSPHNEIATTSSGIPLTPTTSFILPLQPAMNSQLMVGMTGSSPPEAAVEATPETTPLKDMRDIKQPGRAVNSHAVRAIFAVSQPSSPMRKDQQSQFSFPDVSREAEESSHSYLEVNRGTAYDRRLSQVIQDRHNVERSVNTPCPSSLPEINSDLSLVGGSVYPSVTQEVAAVCGECNETDRNLCSVGGLHMPTSRSMHQLAKKRRNRMASYSGNGSCADSRSSAAKKASWSTEAENPMRRTKSCSALSGMRQQHLEENDDEADCSSQRQRGENGNTQKTGSRLQRSGRNLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLIELLLECKEQRIDYERNLLYPQDILDEYIKHAIKANESFDAEQGQLMCLQLEYESYRRSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQNIHQEELGEMRAKYQHELEEKKCLRQANDDLQTRLTSELARHKEMNYELESLRGQVFSLGTELQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQESSNLELKDLRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQKKIIMQMEEKLMMMMQQPQGTTGHNTCSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVDTPTIPDVLNSMAGGAQFEDEVRPPAVDLASSASTASAINIVPHALDLPSTSGGIGHTLTHPHPHPHLHLQQQQQDQLQ
Protein: Protein TAX-1 (TbTAX-1) (Q38DX5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37934199}.
Interaction partners:
Sequence:
MQGANLKVLPSTRAAAKELVDPLDITNVGWSTLEPKFDELMQLMDAPSSGINALAARSAHREKVGAVIEQLLTRAQDESRRLLVEGNGEAAAEAGVKTLRLKERFYGKGSVKLVPAHFHLARTNQFLKRYGNAEEILSLAHFIILQNPDEADATIKAELHQTFGLLYAADNKLDVSVKHLTCATYYLSVMNGPEHVLTTFAYFDLANVFATKACMEAAMALYDTVKNIWLKHLRRVLKDIVDETMAAKLVKRYDDDEVTHEVGHASARAFGKENLADVSKMLFGIFSIQKERLTISHPTTARAQFLLGLYLLWVNKNDEAAEHLLSARTTSQKFYGERHPIVQDIEDWCIWFEIPFRGVAAEQ
Protein: Homeobox protein Hox-C8 (Homeobox protein Hox-3.1) (Homeobox protein M31) (P09025)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-C4
Sequence:
MSSYFVNPLFSKYKGGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD
Protein: CPG2 protein (Q63128)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQSYISFIENSKFFEQYEVTYQVLKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGDTVASLQAWLEDAEKMLSQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEIVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEYTDGTAALSGFAAEAHRKLSEPLEVSFMNVKLLIQDLEDTEKRVPVMDAQYKMIAKKAHLIAKESPKEEANEMLTTMSRLKEQLSKVKECYSPLLYEAQQLSVPLEELETQITSFYDSLGKINEILAVLEHEAQSSALFKQKHQELLACQESCKKSLTLIEKGSQSVQKLVTSSQALKHWDHTKLQKQIADVHHAFQNMIKKTGDWKKHVEANSRLMKKFEESRAELEKVLRAAQEGLEEKGDPEELLRKHTDFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIAVEKDRFSAAVEECRAELERETKLASQEGSEKIIKEHRVFFSDKGPHHLCEKRLRLIEELCVKLPVRDPVRDTSGACHTALKELKASIDNTYMMLMDDPDKWTDYASRFSELSSWVSAKESWLKNIKDQPIDTGNHDEVKRVADEMRNDITKKGEILSWLKSRLKHLIDVSSENEAQKRGDELAELSSSFKALVALLSEVEKMLSNFGECVQYKEIVKSSLEGLMSGSEESKDEAETILDTENLFEAQQMLLRHQQKTKMISAKKRDLQQQMEQGQQGGQAGPGQEELRKLESTLTGLEQSRERQERRIQVSLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIATQAENLVKEAAEMPLGPRNKRLLQQQAKSIKEQVKTLEDTLEEEYVLHNF
Protein: T-box transcription factor 3a (T-box transcription factor TBX3a) (B8JKS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
- NK2 homeobox 5.
- Short stature homeobox 2
- Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
- Bone morphogenetic protein 4.
- Pituitary homeobox 2
- Insulin gene enhancer protein isl-1
- GATA-binding protein 4.
- Natriuretic peptide A
- T-box transcription factor TBX5-A
- POU domain, class 5, transcription factor 1
Sequence:
MRDPVIQGSSMAYHPFLPHRGPEFAMSAMLGHQPPFFPALALPPNGSLSLPGALGKPIMEQLMGAAETGLHFSSLGHQAAHLRPLKTLEPEEEVEDDPKVHLEAKELWELFHKRGTEMVITKSGRRMFPPFKVRCTGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVNFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDHNPFAKGFRDTGNGRREKRKQLALQSMRSYEEQQKKENGTSDDSSGEQASFKCFRQASSPAVSTAGHNHLKDFCDSDEDSDEEDKDANAKEGPDSSKISTTTEDSKDQDAGLGKSVFGESDSSSGRRSEKTRADSRSPITLISSTTRSGEELKSPVREPAKTTDDCRTVSKENYMPLTVQTDGAAHLNQNHLHNFGFPPGLAGQQFFNHLGGAHPFLLHPSQFNMGGAFSNMAAGMGPILAAVSSGGVGSLDGSSLPSPSQSLTGAPMPFHLQQHVLASQGLAMSPFGGLFPYPYTYMAAAAAASSAASSSVHRHPFLSAVRPRLRYSPYSLPSVPDSTLLTTAMQPMASSGLEVKGDGMNTSPASAALDSEVTSRSSGSVSLSPKTCTEKDSSSELQSIQRLVSGLEPKPDRARSVSP
Protein: Pleckstrin homology domain containing, family A member 5 (A0A0N4SUU0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEDKKERPISMINEASNYNMASDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITTDSASTKETNNIPNHRVLIRPEVQNHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLLSEYESGPDCPPQNVHYRPINVNSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTMKENEPIITMVHTMIENSALRPQLYQQLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLT
Protein: Protease (O69636)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MQTAHRRFAAAFAAVLLAVVCLPANTAAADDKLPLGGGAGIVVNGDTMCTLTTIGHDKNGDLIGFTSAHCGGPGAQIAAEGAENAGPVGIMVAGNDGLDYAVIKFDPAKVTPVAVFNGFAINGIGPDPSFGQIACKQGRTTGNSCGVTWGPGESPGTLVMQVCGGPGDSGAPVTVDNLLVGMIHGAFSDNLPSCITKYIPLHTPAVVMSINADLADINAKNRPGAGFVPVPA
Protein: Uncharacterized protein (Q57UA2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Treble clef zinc finger domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Mitochondrial ribosomal protein S18
- Small ribosomal subunit protein uS5 C-terminal domain-containing protein
- Uncharacterized protein
- 30S Ribosomal protein S17, putative
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MFSESLCILSRRFRYNTKFPALVSYNKLPWEVVNHETPQFHMHVAPHYEQLLTLAASSPVPHIISSKHIDVPREHRLRLLPGMLYLLDGDTLPEEFTINRVLDPTALQYYGRLSSQIVTVEAVRMLVSDDLRLLCNCITFKGPLHLPVAPYASLASLRGASQGGTTGSETGSNCFTLYHFVRPNRPPKELQLEKYYIHAPCVAPLSEFASNSDERGNWRPRLQAPKRTQRATPLPAYRPPQSYLMGLAERLAVVPGGCFGRRSLMWGHWF
Protein: Catabolite control protein A (F9UQH6)
Organism: Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum)
Interaction partners:
- HPr kinase/phosphorylase
- Xaa-Pro dipeptidase
- Phosphocarrier protein HPr
- Transcription regulator, GntR family
- Transcription regulator, GntR family
- Heat-inducible transcription repressor HrcA
Sequence:
MEKQTVTIYDVAREAAVSMATVSRVVNGNPNVKPATRKKVLAVIERLDYRPNAVARGLASKRSTTVGVIIPDVTNIYFAALARGIDDIAMMYKYNIILTNSDDAGEQEVNVLNTLMAKQVDGVIFMGNHIDDKLRAEFKRAKAPVVLAGTVDPNNETPSVNIDYAAAVEEVVTNLIARGHKKIALALGSLSQSINAEYRLTGYKRALTKAKIPFDDALVYEAGYSYDAGRKLQPVIADSGATAVFVGDDEMAAGLINASMESGINVPDDLEVVTSNDTIITQITRPAITSITQPLYDIGAVAMRMLTKLMNDKELDEKTVTLPYGIVRRGSTKSAD
Protein: Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B) (P42586)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas. May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:14573534}.
Interaction partners:
- Transducin-like enhancer protein 3
- Oligodendrocyte transcription factor 2
- Histone deacetylase 1
- Hepatocyte nuclear factor 3-beta
- DNA
- Neurogenin-3
- Paired box protein Pax-6
- Paired box protein Pax-4
- Oligodendrocyte transcription factor 1
- Insulin gene enhancer protein ISL-1
Sequence:
MSLTNTKTGFSVKDILDLPDTNDEDGSVAEGPEEESEGPEPAKRAGPLGQGALDAVQSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSKSPEPSADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
Protein: P35 antigen (H7C7P4)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
Sequence:
MKNNKLIAIFLLHVLTVLILISCSLEVKDSNESKKHKKEKRKGKVENLLVAINNLKNPTKPAAGKNKANSKASKQKNNPNANANNAPKKILDPEVAKLIQKILDRSENIIQISEMDSSRGEPNDQFGMRAEIFSKIFFNANSTVHFDSHEYTEERRMLYTSLNFNEGKIFNLGQILSKLSQDSNYRGLVKETLINRGFSIQLAMEEISAKILNVKDKLQQLNKPNLETLYNDFEKLTSLKEKWLKDTDDLIDEYNTNPDLQTDVSKLNDTLRSKNSRAQFANIHDIILDLVNTTTNILAPIQ
Protein: Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) (Q15399)
Organism: Homo sapiens (Human)
Function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16880211}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPQ1}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269|PubMed:16880211}.
Interaction partners:
- Toll-like receptor 2
- Toll-like receptor 6
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 4
- Toll/interleukin-1 receptor domain-containing adapter protein
- Toll-like receptor 10
- Platelet glycoprotein 4
- Lymphocyte antigen 96
- Scavenger receptor class B member 1
- Lysosome membrane protein 2
Sequence:
MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK
Protein: Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) (A2A288)
Organism: Homo sapiens (Human)
Function: May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:26134560}. Note=Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560). {ECO:0000269|PubMed:26134560}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
Interaction partners:
- Cannabinoid receptor 2
- Interleukin-12 receptor subunit beta-1
Sequence:
MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP
Protein: Tubulin beta chain (B1PBW2)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MREILHVQGGQCGNQIGSKFWEVICDEHGVDPTGKYSGDGSSDIQLERIDVYYNEASGGRYVPRAVLMDLEPGTMDSIRSGPIGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDAVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYVSLTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMMNVQNKNSSYFVEWIPNNVKSSVCDIPPRGLKMSSTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMDFTEAESNMNDLVAEYQQYQDATVEDEEEYEGEEGLDENYET
Protein: FI21110p1 (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform C) (Q9VYE3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cell division cycle 5, isoform A
- Serine/arginine repetitive matrix protein 1
- RING-type E3 ubiquitin transferase
- Pre-mRNA-splicing factor CWC22 homolog
- Peptidyl-prolyl cis-trans isomerase
- Peptidyl-prolyl cis-trans isomerase
- ATP-dependent RNA helicase WM6
- Serrate RNA effector molecule homolog
- Pre-mRNA-processing factor 17
- MIP04834p
Sequence:
MAKQYGLILPGQQKKVPLKRVERPSIFDENSDSETDDDPAAPQFQPRTGGVSMGPSLMERRVARRQQEKALAEDPTIFQYDELYDDMDSKREEAKQTKSQEPRKPKYIGRLMEHAERRKLEKELRIERQVQKDREAEGEMYKDKDTYVTAAYRKKLESIRQMQEQEQRDEYLEAIGDVTKQKDLDGFYRHLYEQKLGGPAQQDVVKPKTAPTTDEVAYKPIKAEAVKHRSYRRRRPSEDEEEQTKSKSDAASDATKSTDQTESIPAQAHLTNNIDADSDFSIDDSSDEEDEKENEKEKNKLSQIKKEDKDKAPESSEPVKPKEPEASQQSPTKKDDSNAEVNEKDLPVPRVTKPPVDRTLFWRKRTVGEVLAAALARYEERKRARLQ
Protein: Ankyrin repeat domain 11 isoform A (Ankyrin repeat domain containing 11) (X5D778)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKIAPPPSLAEPLKELFRQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLPA
Protein: S-adenosyl-L-methionine-dependent Diels-Alderase iccD (EC 2.1.-.-) (C-methyltransferase iccD) (C-MT iccD) (Ilicicolin H biosynthesis cluster protein D) (Pericyclase iccD) (A0A482NB13)
Organism: Talaromyces variabilis (Penicillium variabile)
Function: S-adenosyl-l-methionine-dependent Diels-Alderase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IccD catalyzes the Diels-Alder reaction that converts the acyclic 2-pyridone intermediate to 8-epi-ilicicolin H. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerization. IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASSEVFTSEEAAQRAIKTYYESQESRMGYELVFGGTQHFGYYTPGTWSPFPIDKSLRRMEEKLMGWLALPAGSRILEAGCGVGHVALYLAKHGMRVTGVDIIDHHVEQARRSAQKANLPKDQIVIEKMDFERLEAIPSASHDGAFTMQSLGHAFSAEKALAGFFRVLKPGGRFALVEVERRPNAEADKKNPRLTEQLSMINVGTGMPTNERSHDGFYKGLLEEAGFVDIESRDISDNILPVVRMFYVVLLVPYLFVRLLGIEKHFVSMLAGTAGYVGYDRWRFMVVTGRKP
Protein: DNA (cytosine-5)-methyltransferase (EC 2.1.1.37) (F1RCN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037404}.
Interaction partners:
- E3 ubiquitin-protein ligase UHRF1
- DNA
- Histone deacetylase 1
- Histone-lysine N-methyltransferase EZH2
- Ubiquitin carboxyl-terminal hydrolase 7
- Methyl-CpG-binding protein 2
- DNA
- DNA
- Lysine-specific histone demethylase
- Euchromatic histone-lysine N-methyltransferase 2.
Sequence:
MPTKTSLSLPEDVKERLQVLDEGGDSLSDEECVKEKLRLLQEFLLADTQDQLKNLEDKLKSSELSTEVYMSEVKAVLKKALGVVKEGDGVEQNGHSNGFSENGSHKDNGEQEGAMDTQEEGDAIKSPSAPKGRGGRRSKADSEPKKSPASSRVTRNTGKQQTIVSMFSRVPKRKSDELNGEPANGDTEIKTEETITEEVREEKRLKTEDEKPEAENAANLKPVSTAKTPPPKCPDCRQYLDDSDLKFFQGDPDDALDEPEMLTDERLSLFDSNEDGFESYEDLPQHKITNFSVYDKRGHLCPFDSGLIEKNVELYFSCAVKPIYDDNPCMDGGVPAKKLGPINAWWITGFDGGEKALIGFTTAFADYILMDPSEEYSAIFALMQEKIYMSKIVVEFLQKNQDATYEDLLNKIETTVPPAGLNFNRFTEDTLLRHAQFVVEQVESYDEAGDSDEQPIIITPCMRDLIKLAGVTLGKRRAARRQAVRHPTKIEKDNKGPTKATTTKLVYLIFDTFFSDQIDQNNKDGGVKRQRCGVCEVCQAPDCGKCSACKDMIKFGGSGRSKQACQKRRCPNLAVKEAEDDENMDEEDVLPVKDTKKMSQTKKKKQTKNKISWVGEPLKTEGKKEYYMKVRVENEVLEVGDCVSVSPDDPSHPLYLARITALWDDGEKMFHAHWFCRGTDTVLGESSDPLELFLVDECEDMQLSFIHGKVNVFYKAPSENWYMEGGMDEDIKVIDDDGESFFYQLHYEGECARFETPPKVTPSEDCKYKFCASCTRNKEREAESVPHAYEPLEDEESDSKVFYGLVNYKGEQYKVGDSVYLPPEAFNFVVKAASPVKRSHRKDDVDEDLYPEYYRKSSDYIKGSNLDAPQPFRIGRIKEIFCNKRSNGKPDTSEIKLRLYKFYRPENTHKGPKGAYHSDINQLYWSDEEATVSMTEVLTRCRVEYAEDLVESVQDYSNKGPDRFYFLEAYNAKTKSFEDPPNHARSAVNKGKGKGKGKGKGKGKAAPQEPQDQEPQEPVVPKLRTLDVFSGCGGLSEGFHQAGISETHWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSYLSYCDYYRPKFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPRYPEPLHVFAPRACSLSVAVDEKKYVSNVTRGNGGIYRTITVRDTMSDLPEIRNGAAALEISYNGEPQSWFQRQIRGSQYQPILRDHICKDMSALVAARMRNIPLAPGSDWRDLPNFEVRLRDGTTTKKLRYTHPDKKNGRSGTGALRGVCSCSEGKPCDPADRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRFFGNVLDKHRQVGNAVPPPLSKAIGLEVKKCVLEKMRENATEPVKQEKMELSD
Protein: Seizure 6-like protein (Q9BYH1)
Organism: Homo sapiens (Human)
Function: May contribute to specialized endoplasmic reticulum functions in neurons.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Unconventional myosin-XVIIIb
- G protein-coupled receptor kinase 3
Sequence:
MPAARPPAAGLRGISLFLALLLGSPAAALERDALPEGDASPLGPYLLPSGAPERGSPGKEHPEERVVTAPPSSSQSAEVLGELVLDGTAPSAHHDIPALSPLLPEEARPKHALPPKKKLPSLKQVNSARKQLRPKATSAATVQRAGSQPASQGLDLLSSSTEKPGPPGDPDPIVASEEASEVPLWLDRKESAVPTTPAPLQISPFTSQPYVAHTLPQRPEPGEPGPDMAQEAPQEDTSPMALMDKGENELTGSASEESQETTTSTIITTTVITTEQAPALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDGELLSIRGVDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFMLSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSAPCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDKDRMTVHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPYWNDTEPLCRAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHCVSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWNGPLPVCKVNQDSFEHALEVAEAAAETSLEGGNMALAIFIPVLIISLLLGGAYIYITRCRYYSNLRLPLMYSHPYSQITVETEFDNPIYETGETREYEVSI
Protein: Zinc finger protein 3 (Q39262)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development. Involved in the regulation of vegetative development and fertility. Modulates red light signaling in seedling photomorphogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q39261}.
Interaction partners:
- F1O19.11 protein
- At3g23140
- C2H2 and C2HC zinc fingers superfamily protein
- Zinc finger protein 11
- Zinc finger protein 10
- Zinc finger protein AZF1
- C2H2-type zinc finger protein
Sequence:
MDASIVSSSTAFPYQDSLNQSIEDEERDVHNSSHELNLIDCIDDTTSIVNESTTSTEQKLFSCNYCQRTFYSSQALGGHQNAHKRERTLAKRGQRMAASASAFGHPYGFSPLPFHGQYNNHRSLGIQAHSISHKLSSYNGFGGHYGQINWSRLPFDQQPAIGKFPSMDNFHHHHHQMMMMAPSVNSRSNNIDSPSNTGRVLEGSPTLEQWHGDKGLLLSTSHHEEQQKLDLSLKL
Protein: Calpain-5 (EC 3.4.22.-) (Sex-determining transformer protein 3) (Q22036)
Organism: Caenorhabditis elegans
Function: Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis. Part of the necrosis cell death pathway. Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa.
Interaction partners:
- Protein phosphatase fem-2
- Sex-determining transformer protein 2
- Calpain catalytic domain-containing protein
- Sex-determination protein fem-3
- Sex-determining transformer protein 1
Sequence:
MTRSEKTRHFGNQNYEKLRKICIKKKQPFVDTLFPPTNQSLFLEQRQSSDIVWKRPGELHPDPHLFVEGASPNDVTQGILGNCWFVSACSALTHNFKLLAQVIPDADDQEWSTKHAYAGIFRFRFWRFGKWVEVVIDDLLPTRDGKLLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHLSDALQDVSGGVAETLHVRKFLKDDPNDTELKLFNDLKTAFDKGALVVAAIAARTKEEIEESLDCGLVKGHAYAVSAVCTIDVTNPNERSFTSFIMGSKRKQNLIRLQNPWGEKEWNGAWSDDSPEWQNVSASQLSTMGVQPANSDSDDGDFWMPWESFVHYFTDISLCQLFNTSVFSFSRSYDEQIVFSEWTTNGKKSGAPDDRAGGCHNFKATFCNNPQYIFDIPSPNCSVMFALIQNDPSEGLKKREPFVTIGMHVMKVENNRQYRVHTAMHPIAISDYASGRSVYLHLQSLPRGRYLLIPTTFAPKEQTLFMLRVYSDEHIHFSPLTKHAPKLGLLKCKSAQSVTRLTIHGVDFNSASTGTHNVYAILKDSRKSFRTKTLSGVKSIQWDEQFLFHKSKNRQQYKIEVWEDRKMARDHLLAQSVIIALIDNENRDTTLQLTDPRGTVIGTVSVTVSAFDDPMYL