Protein: Battenin (Protein CLN3) (Q61124)
Organism: Mus musculus (Mouse)
Function: Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission. Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing. Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis. At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex. Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory. Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process. Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:15588329}; Multi-pass membrane protein {ECO:0000255}. Late endosome {ECO:0000250|UniProtKB:Q13286}. Lysosome {ECO:0000269|PubMed:11590129, ECO:0000269|PubMed:16714284, ECO:0000269|PubMed:19941651}. Membrane raft {ECO:0000269|PubMed:24227717}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24227717}. Synapse, synaptosome {ECO:0000269|PubMed:11590129}. Early endosome membrane {ECO:0000269|PubMed:15588329}. Late endosome membrane {ECO:0000269|PubMed:15588329}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:16714284}. Note=Excluded from the synaptic vesicles. {ECO:0000269|PubMed:11590129}.
Interaction partners:
- Bis
- Ceroid-lipofuscinosis, neuronal 6
- Palmitoyl-protein thioesterase 1
- Protein CLN8
- Major facilitator superfamily domain-containing protein 8
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Tripeptidyl-peptidase 1
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Cathepsin F
- Protein Hook homolog 1
Sequence:
MGSSAGSWRRLEDSEREETDSEPQAPRLDSRSVLWKNAVGFWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHVEPGPTPTPHNSSSRFDCNSISTAAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLASISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQAGLSPQHTLLSMLGIPVLLLASYFLLLTSPEPLDPGGENEAETAARQPLIGTETPESKPGASWDLSLQERWTVFKGLLWYIIPLVLVYFAEYFINQGLFELLFFRNTSLSHAQQYRWYQMLYQAGVFASRSSLQCCRIRFTWVLALLQCLNLALLLADVCLNFLPSIYLIFIIILYEGLLGGAAYVNTFHNIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHLP