wanglab/gogpt-training-data huggingface dataset:
Protein: Trafficking protein particle complex subunit 2-like protein (A1Z8I0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Probable trafficking protein particle complex subunit 2
- FI18195p1
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 11
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit
- Protein brunelleschi
Sequence:
MAFCIAVIGKDNAPLYLTTSDMEQELELQYHVNAALDVVEEKCLIGKGAPESKELYLGLLYSTENHKIYGFVTNTRVKFIVVIDSSNVALRENEVRAIFRNLHLLYTDAICNPFYIPGESLTSKKFDRAVQKLMSGTA
Protein: Coiled-coil domain containing 66 (C9JYB8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRC
Protein: Major vault protein (MVP) (Q62667)
Organism: Rattus norvegicus (Rat)
Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus {ECO:0000250|UniProtKB:Q14764}.
Interaction partners:
- Telomerase protein component 1
- Poly [ADP-ribose] polymerase
Sequence:
MATEEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDTQSSVLFDITGQVRLRHADQEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVVEIIQATVIKQNQALRLRARKECFDREGKGRVTGEEWLVRSVGAYLPAVFEEVLDLVDAVILTEKTALHLRALQNFRDLRGVLHRTGEEWLVTVQDTEAHVPDVYEEVLGVVPITTLGPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLERGIQDVYVLSEQQGLLLKALQPLEEGESEEKVSHQAGDCWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQKGTAKPLQPSAPRNKTRVVSYRVPHNAAVQVYDYRAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPKARDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVKKVREMELIYARAQLELEVSKAQQLANVEAKKFKEMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFSTAFGLLGLGSDGQPPAQK
Protein: Low-density lipoprotein receptor (LDL receptor) (P01130)
Organism: Homo sapiens (Human)
Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:19520913}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01131}. Membrane, clathrin-coated pit {ECO:0000303|PubMed:6091915}. Golgi apparatus {ECO:0000269|PubMed:17461796}. Early endosome {ECO:0000269|PubMed:17461796}. Late endosome {ECO:0000269|PubMed:17461796}. Lysosome {ECO:0000269|PubMed:17461796}. Note=Rapidly endocytosed upon ligand binding. Localized at cell membrane, probably in lipid rafts, in serum-starved conditions (PubMed:30443021). {ECO:0000269|PubMed:30443021, ECO:0000269|PubMed:3104336}.
Interaction partners:
- Proprotein convertase subtilisin/kexin type 9
- Low density lipoprotein receptor adapter protein 1
- E3 ubiquitin-protein ligase MYLIP
- Apolipoprotein B-100
- Disabled homolog 2
- Apolipoprotein E
- Alpha-2-macroglobulin receptor-associated protein
- Beta-2-glycoprotein 1
Sequence:
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
Protein: Zinc transport protein ZntB (Q9EYX5)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake (By similarity).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01565, ECO:0000269|PubMed:12486076}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01565, ECO:0000269|PubMed:12486076}.
Interaction partners:
- Cation-efflux pump FieF
- P-type Zn
- Zinc transporter ZitB
- Zinc transporter ZupT
- High-affinity zinc uptake system protein ZnuA
- Copper-exporting P-type ATPase
Sequence:
MEAIKGSDVNVPDAVFAWLLDGRGGVKPLEDNDVIDSQHPCWLHLNYTHPDSARWLASTPLLPNNVRDALAGESSRPRVSRMGEGTLITLRCINGSTDERPDQLVAMRLYMDERFIVSTRQRKVLALDDVVSDLQEGTGPVDCGGWLVDVCDALTDHASEFIEELHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDHRRRMQDIADRLGRGLDEIDACIARTGIMADEIAQVMQESLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWRFGFSLFCILLVVLIGGVTLWLHRSKWL
Protein: Protein kinase domain-containing protein (Q384A0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLQKEVLGSNANSSTVLVKDTEAGGELRVVKRINVTSWAESDVDKTLETYNAIASANIPNMVKLYVAMRQSSSISVVSSYCLGEELQEYLDEKISCPLDEVTALRWMRNIARVVQQVHNLPLNNRVACFHGPLIDRIFVVDDGKEVCVGLPLPRVLYFKWLEERETYGVKLHHEYPPEVLRGRYYYTQASDIWQLGLVGMKLLAANASFDRRSAAIRTLIASMMNPIMRKRPNIEEVNRKLGEITRERSISCLSSADVNTPTSYERFLTPRSAVMEEPIGMTSLDEYDTFTTDLSKTNFDEVTQSTHKHAWRNRLQPSWYNQAMKQFEELQRMNSTPLTSRSRPASPTPATGGAVSPRARRDAKATNARDRSGGARPSPRRRASSSTLTGPQKNRTLERVPSSARRDLAMPRMLNNIPSQRSRNAHRLELEEKKRRQQALEREAHAMHRVHENRMREIRKNQDESMKHDIRKYIKQWREQSTAAKDDSTSYSEHNGVAIFVPKNPPPPGRSPNVDTKAKQQPLNSEGDTHRRVFSDELTHAAAGPVVHGSTPRPYSATRHPRTPPSATPKRSASIYRIRGISPKVPHSRANPSDRYKVTESAPTTTVSCANPSSSKNSGTTAYQTSETSSGTYPSGTNRAGQSNSRTISVLGEDATKPSCTAGVPGTNRLAAESLRCSAGRLREALEKLLPTRELFVETMEVVDAFVVRSEIERCNPRFNTVFMHTLRKLMNDDELLLSAVPMCAQLVSLLSLLQGGEQPEGT
Protein: Interleukin-7 (IL-7) (P56478)
Organism: Rattus norvegicus (Rat)
Function: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P13232}.
Interaction partners:
- Interleukin-7 receptor subunit alpha
- Interleukin 2 receptor, gamma, isoform CRA_a.
- Interleukin 9
- Interleukin-4
- Interleukin-5
- Tyrosine-protein kinase JAK3
- Interleukin-10
- Interleukin-2
- Interleukin-3
- Interleukin-6
Sequence:
MFHVSFRYIFGIPPLILVLLPVTSSDCHIKDKDGKAFGSVLMISINQLDKMTGTDSDCPNNEPNFFKKHLCDDTKEAAFLNRAARKLRQFLKMNISEEFNDHLLRVSDGTQTLVNCTSKEEKTIKEQKKNDPCFLKRLLREIKTCWNKILKGSI
Protein: PDCD6 protein (Programmed cell death 6) (Q86W51)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00049643}.
Interaction partners:
Sequence:
MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNG
Protein: Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) (O75414)
Organism: Homo sapiens (Human)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Interaction partners:
- Inosine triphosphate pyrophosphatase
- Thymidylate kinase
- Adenylate kinase 9
- Guanosine-3',5'-bis
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- Cancer-related nucleoside-triphosphatase
- CTP synthase 1
- GTP:AMP phosphotransferase AK3, mitochondrial
- Nucleoside diphosphate kinase, mitochondrial
- Guanylate kinase
Sequence:
MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA
Protein: TSC complex subunit 2 (A0A2R8Y7X5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANVSGGGSRRELVGQAQVPPDSELTPCLRPQMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
Protein: piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (Q8NHP7)
Organism: Homo sapiens (Human)
Function: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:H9IUR0}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:H9IUR0}.
Interaction partners:
- Putative ATP-dependent RNA helicase TDRD12
- Piwi-like protein 2
- Protein bicaudal D homolog 2
- Protein bicaudal D homolog 1
Sequence:
MEDSEFLAYVELLDEVEQGSVRAKASSVSLHAERTWMEKMKVEDLNVCEPASPAPEAPATSLLNDLKYSPSEEEEVTYTVINQFQQKFGAAILHIKKQNVLSVAAEGANVCRHGKLCWLQVATNCRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVLQFSMETGGYLPNCITTLQESLIKHLQVAPKYLSFLEKRQKLIQENPEVWFIRPVSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVDGYLNTYREGSADRLGGTEPTCMELPEELLQLKDFQKQRREKAAREYRVNAQGLLIRTVLQPKKLVTETAGKEEKVKGFLFGKNFRIDKAPSFTSQDFHGDVNLLKEESLNKQATNPQHLPPTEEGETSEDSSNKLICTKSKGSEDQRITQKEHFMTPKHEFQASLSLKEETEQLLMVENKEDLKCTKQAVSMSSFPQETRVSPSDTFYPIRKTVVSTLPPCPALEKIDSWISPFLNLP
Protein: NAD(+) kinase (EC 2.7.1.23) (A0A8I5ZN64)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MCSFWKDSTQVSGVPTREHPDCSRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKIRDASLLQPFKELCIYLMEENNMIVYVEKKVLEDPAIVGDENFGPVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFNFENFQSQVNQVIEGNAAVILRSRLKVRVVKEPRDKKTAIHNGLSENGLDTEGGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMVHPNVPAIMVTPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVCDPVSDWFESLAQCLHWNVRKKQAHFPEDEEDQDEEDS
Protein: Ubiquitin domain-containing protein DSK2a (Q9SII9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
Subcellular location: Nucleus {ECO:0000269|PubMed:23336935}. Cytoplasm {ECO:0000269|PubMed:23336935}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- Protein NBR1 homolog
- 26S proteasome regulatory subunit RPN13
- Probable ubiquitin conjugation factor E4
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- Ubiquitin receptor RAD23d
- Probable ubiquitin receptor RAD23a
- 26S proteasome non-ATPase regulatory subunit 13 homolog A
Sequence:
MGGEADSRQPLTAEGVAVAVNVRCSNGTKFSVTTSLDSTVESFKELIAQNSDVPANQQRLIYKGRILKDDQTLLSYGLQADHTVHMVRGFVPSSPSAPAANAGNQTTAPQAVGSNDSSNLGGGESLFPGLGFNPLGGGNAMAGLFGSGLPDLEQAQQQLAQNPNMIREMMNTPAIQNLMNNPEFMRSMIMNNPQMRELVDRNPELGHVLNDPSILRQTLEAARNPELMREMMRNTDRAMSNIESMPEGFNMLRRMYENVQEPLMNATTMSENAGNNTSSNPFAALLGNQGVTTQGSDTSNNISAPNAETGTPNANPLPNPWGATAGQTTAPGRTNAGLGGLGGLGGLGGLGMLGADSPLGATPDASQLSQILQNPAMSQMMQSVLSNPQYMNQLMSLNPQLRSMLDMNPQLREMMQNPDFLRQFSSPEMMQQMMSLQQSLFSQNRNTAGQDPTQTGAATGTANNGGLDLLMNMFGSLGAGGLSGTNQPNVPPEERFATQLQQLQEMGFYDRAENIRALLATNGNVNAAVERLLGSIGQ
Protein: Olfactory receptor 2AT4 (Olfactory receptor OR11-265) (A6NND4)
Organism: Homo sapiens (Human)
Function: Olfactory receptor. Activated by the synthetic sandalwood odorant sandalore. Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs. Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes. Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24999593}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MDATACNESVDGSPVFYLLGIPSLPETFFLPVFFIFLLFYLLILMGNALILVAVVAEPSLHKPMYFFLINLSTLDILFTTTTVPKMLSLFLLGDRFLSFSSCLLQMYLFQSFTCSEAFILVVMAYDRYVAICHPLHYPVLMNPQTNATLAASAWLTALLLPIPAVVRTSQMAYNSIAYIYHCFCDHLAVVQASCSDTTPQTLMGFCIAMVVSFLPLLLVLLSYVHILASVLRISSLEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIMGNVVYAILTPILNPLIYTLRNRDVKAAITKIMSQDPGCDRSI
Protein: GF14 protein phi chain (F4HWQ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAAPPASSSAREEFVYLAKLAEQAERYEEMVEFMEKVAEAVDKDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVTTIRDYRSKIESELSKICDGILKLLDTRLVPASANGDSKVFYLKMKGDYHRYLAEFKTGQERKDAAEHTLTAYKAAQDIANAELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQFCIMYDNTLMSFLVLISDSVVLISTINQDESPEEIKEAAAPKPAEEQKEI
Protein: Transcription termination factor FttA (EC 3.1.-.-) (O27271)
Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Interaction partners:
- Ribonuclease Z
- Ribonuclease J
- Probable Brix domain-containing ribosomal biogenesis protein
- Exosome complex component Rrp42
- Exosome complex component Rrp41
- Ribosome maturation protein SDO1 homolog
- Exosome complex component Csl4
- Proteasome subunit beta
- Conserved protein
Sequence:
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKRIIIRSDRSVLMDPEKAIRKIHEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTSREIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKKILQQLGNRIHQKPKYDNDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVIITHAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKKSVKHTITLDYGEVTDIAPDIRLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRLLEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKTIYSTLRRGGKILIPVFAVGRAQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFISDIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGSLGRRIQKGWKEIPLKDEDDKMRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKILLCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ
Protein: GBF-interacting protein 1-like (Protein GIP1-like) (A4FVR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a transcriptional coactivator of LOB domain-containing proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:24484953}.
Interaction partners:
Sequence:
MSSSDGGSSRVSIPYHLRKTLQKIREYTGKQHSDEDIFAVYKDSFNDPHETAQKLLFLDTFHEVRSKREKKKEPIVPVTQPSGRGGRRNFASSNSYQGSGRNASFKRENGANHVTRGSRTAQPATNKASNITVPNETKVSGPASIPSEVSNHKAQDDPSLISASRCSSKSDQAIEIETASKQGKNQSLPKPDVSEQSHVTFPFHLQVAKGLQNGLTFGSFDSNFVKEVSSSNGASGGYDSNFESSHGTGDDERESSPTTNGITGVASAREETSTVSEDKDYGISNSATGAEPVVHSDHIVPPVEEVPKEEALSNTETHQIAYGQEAPLSVFGLVPSLSAIGQPVNTEAAETQPGNSNSPPISLVSYPPDQSSIAAATQQTNFLRQQYPPNFFPYGYYSPYYMPPPYIHQFLSPNGIPQQSYFPQGAALTAPSHAKPVDNTENPPTTNPYLHTSPMVASSIPSTTTLNSIHSEEKASHLTESAAAWIGQGFGNLQVNPMYNLAYQGQPLGFPVVQAGHGGLMGMHQPTQPMAAASTTYQTLPPPPHTTTAMGEPIGHPHIAYQQPQAALTNWVNNY
Protein: Cdc73 protein (Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)) (Parafibromin isoform 2) (Q7T3D4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADVLSVLRQYNIQKKEIVAKGDEVIFGEFSWPKNVKTNYVIWGTGKEGQPKEYYTLDSILFLLNNVHLPHPSYVRRAATENIPVVRRPDRKDLLSYLNGESSSSTSIDRSAPIEIGLQRPTQVKRAADEVSSEAKKPRVEDEERVRLDKERLAARLEGHKESIVQTDQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITQKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSSGKNFSKNIFAILQSVKAREEGRAPEQRQTQNQTQVDPAIRNKQPVPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKAQTPAMQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVTSEEKKKQGIQRDNEVLLQRRKDQVQPGGATLSVTVPYRVIDQPLKLAPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIRAFHLKYDEARMDPNVQKWDVTVLELSHHKRHLDRPVFLRFWETLDRSG
Protein: Uncharacterized protein (Q38D27)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MDVCEGLRVPVGHMSGTGGLGLTAGGGGTATSSVFSDLRELNEAKVSNILSYLDDVVSTRPPFPASFGPSACRDVYMPANISDGGVALAPSAALLQPSTQLPPFGGSASCLTSHIIGCGPDVRSDVYHGIKAKISALQFSNDELRAENEELKERVKMAREREAERLGSQEAAARNELEGLRKKLRETERNYERVVQEFQRERSQLTQAVESVTSQLRQEMSRREEEIARLESANATAIAQLKTRWQAQEKAAREKWRIAEAKRIKENTLQSLEPDIVLLLNRHKAEKARMREEFENELRQRDEVIAAKEATLEESRARLEREASATRAREQQEFRDRLKEEMDRVNRQLEEERRLAKQKHDDLEIFAEDRKNTMQREISQLQKEVFTLREAAATEKAKIHDEVAREVANITANSNQIVSDLKEKLMLEFSRREQETKAYNVQYLAAREEELRHKFEAERDAAVAEVTRRAEQQHLQTLMESHGADSVLRDRCAQMGRENERLRAEVELLQGNLRSVVEEIGRKEEEMSRLRETSDLTNQRVKEIQEKVRAEDEARMHVLDSEWQRKLRQFEIKHVEEVGAMQHELEKVTIELQAVKNAAALEQRSIEQKHNAELTSINERVLVALATKDNTLRAQTEQISVLQEAIRLRDEQIARHRELL
Protein: Tyrosyl-DNA phosphodiesterase 1 (G3V2F4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFIGHGYGTFLMSKHRIRMGTCGCPPENLEAL
Protein: RE23690p (Q8SZ14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MISTGQQQSTLRTQRPSFPCNANSKSLKVNDWSQKDRKQEPSKERNNQKYPKITTENKQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYEDNEDEFVRDPFIYGEVKEKEDEAVVLAFDAVSEDGFDLLSMTTTQQNAVKPLDPPEDCLHYASSDDGEDENAIPAYAVDHRVLDVDYPRDAVRSAFTLPARDIESIIELQQRIRVQLVSLVNPHNFNFWIYNDDFKDYEAQFANMQTFYESSESKNYTMPLFLITTDHLCVVRCTSGWERAKVLGYRSSNNKMTIEVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRLLYAKVEAIKNNTAYLVLVDTESQGHTVNLNRSLIETGWVRRCTSA
Protein: Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14) (Q8TDB8)
Organism: Homo sapiens (Human)
Function: Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27460888}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 2, facilitated glucose transporter member 3
Sequence:
MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNTGVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINRKKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQQPIYATISAGVVNTIFTLLSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMGMNSIEPAKETTTNV
Protein: Syntaxin-18 (Q68FW4)
Organism: Rattus norvegicus (Rat)
Function: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Vesicle-trafficking protein SEC22b
- Centromere/kinetochore protein zw10 homolog
- Vesicle transport protein USE1
- RAD50-interacting protein 1
- Syntaxin-5
- NBAS subunit of NRZ tethering complex
- Syntaxin-8
- Sec1 family domain-containing protein 1
- Syntaxin-7
- Syntaxin-6
Sequence:
MAVDITLLFRASVKTVKTRNKALGVAVGGGADGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKEYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCKDAIQQLRTEAHKEIHSQQVKEHRTAVLDFVEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPHTKRKEPASEKSSHNASQDSEEKPAAEDLPEKPLAESQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGKVVEISRLQEIFTEKVLQQETEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS