wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (IL-20R1) (Q6PHB0)
Organism: Mus musculus (Mouse)
Function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Interleukin-24
- Interleukin 20 receptor beta
- Interleukin-19
- Interleukin-20
- Interleukin-10 receptor subunit beta
- Tyrosine-protein kinase JAK1
- Interleukin-22
- Interleukin-10
- Interferon lambda-3
- Interferon lambda-2
Sequence:
MHTPGTPAPGHPDPPPLLLLTLLLLLAASGRAVPCVFCGLPKPTNITFLSINMKNVLHWNPPESLHGVEVTYTVQYFIYGQKKWLNASKCGSINRTYCDLSVETSDYEHQFYAKVKAIWEARCSEWAETERFYPFLETQVSPPEVALTTGEKSISIALTAPEKWKRNPQDHTVSMQQIYPNLKYNVSVYNTKSRRTWSQCVTNSTLVLSWLEPNTLYCVHVESLVPGPPRLPMPSQKQCISTLEVQTSAWKAKVIFWYVFLTSVIVFLFSAIGYLVYRYIHVGKEKHPANLVLIYRNEIGTRVFEPTETITLNFITFSMLDDTKISPKDMNLLDKSSDDISVNDPEHNEAWEPHWEEVEGQHLGCSSHLMDAVCGAEQRDGDTSLTQHGWLNSTIPTGETDTEPQYKVLSDFYGEGEIQLSCEPEEAARTEKISEPLVTSANLDPQLEDLHHLGQEHTVSEDGPEEETSITVVDWDPQTGRLCIPSLPIFGRDPENYGHYERDQLLEGGLLSRLYENQAPDKPEKENENCLTRFMEEWGLHVQMES
Protein: Large ribosomal subunit protein uL6B (60S ribosomal protein L9-B) (L8) (RP24) (YL11) (P51401)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL8B
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein eL27A
- Large ribosomal subunit protein eL39
Sequence:
MKYIQTEQQIEIPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNGDRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFIVEDM
Protein: Peroxidase 66 (Atperox P66) (EC 1.11.1.7) (ATP27a) (Q9LT91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Interaction partners:
- At1g64405
- Uncharacterized protein
- Transmembrane protein
- At1g70770
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- At3g07640
- Disease resistance protein-like
Sequence:
MAFSKGLIFAMIFAVLAIVKPSEAALDAHYYDQSCPAAEKIILETVRNATLYDPKVPARLLRMFFHDCFIRGCDASILLDSTRSNQAEKDGPPNISVRSFYVIEDAKRKLEKACPRTVSCADVIAIAARDVVTLSGGPYWSVLKGRKDGTISRANETRNLPPPTFNVSQLIQSFAARGLSVKDMVTLSGGHTIGFSHCSSFESRLQNFSKFHDIDPSMNYAFAQTLKKKCPRTSNRGKNAGTVLDSTSSVFDNVYYKQILSGKGVFGSDQALLGDSRTKWIVETFAQDQKAFFREFAASMVKLGNFGVKETGQVRVNTRFVN
Protein: Cysteine-rich venom protein kaouthin-2 (Cysteine-rich venom protein 23) (CRVP-23k) (P84808)
Organism: Naja kaouthia (Monocled cobra) (Naja siamensis)
Subcellular location: Secreted {ECO:0000269|PubMed:15670767}.
Interaction partners:
Sequence:
MIAFIVLLSLAAVLQQSSGTVDFASESSNKRENQKQIVDKHNALRRSVRPTARNMLQMEWNSNAAQNAKRWADRCSFAHSPPHLRTVGKIGCGENLFMSSQPYAWSRVIQSWYDENKKFVYGVGANPPGSVIGHYTQIVWYNSHLLGCGAAKCSSSKYLYVCQYCPAGNIIGSIATPYKSGPPCGDCPSACVNGLCTNPCKHHNVFSNCQSLAKQNACQTEWMKSKCAASCFCRTEII
Protein: Integral membrane protein 2 (Q2PDW1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU367061}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU367061}.
Interaction partners:
Sequence:
MVFNRPQHHCIKSFLLFLIAVVVMLLGVLGGWTLYRVYAPSHSSMRYHALCEIPYPEDSMEMARVYPRTVEPFALNWRSLLPELAQPMPNSGSLDESHFREDIELDGDSDDEGYARVDVPDFKDGRRGRFMHDFKENQSAIIDTTTGRCFIMPLDRDTTLPPTSFVDLIKKMSTGYYNIDTERVRRQMRVVMPRITDVSLISERIANECFDMKVYMMEKFVSGVSKRSADPLPESAKYAEFMGKGVIEYDLANIAEVEAYEANEARQQA
Protein: ATP synthase subunit K, mitochondrial (P81451)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. The K chain binds the dimeric form by interacting with the G and E chains.
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein.
Interaction partners:
- ATP synthase subunit J, mitochondrial
- ATP synthase subunit d
- ATP synthase subunit 4
- ATP synthase subunit g, mitochondrial
- ATP synthase subunit f
- ATP synthase subunit e, mitochondrial
- ATP synthase subunit 5, mitochondrial
- ATP synthase subunit a
- ATP synthase subunit epsilon, mitochondrial
- ATP synthase subunit beta, mitochondrial
Sequence:
MGAAYHFMGKAIPPHQLAIGTLGLLGLLVVPNPFKSAKPKTVDIKTDNKDEEKFIENYLKKHSEKQDA
Protein: Uncharacterized protein (Q383K7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVYNKVLRALVCRAAAYNRPFNSHDSLLILKSLHTLRYRSSEVKVICEKCAFAIASAHISVPVERVIEALNALTSLQAGSKPVVWERLAARLLEVTTRTASPQAVQKAAVVVVKLGRRYGRRDVAEHIFDVLMELLPLYPQDVALRLAVISVFPYTVSNNGSGAVSIGGQIEGNTRVDGVLNAALHLVETGTLRTVRGNSALQALHMYPVIAWCWKESGIHGCQVGDELANPTGGKKQGLWADPWVKVKNAFFEDLRLHTVVPGGYAQFLHDFLSSCARKGDQSNDYQFTLKLLGVALHRDFKRALNSYDVAKMATVVSGEVQRHGRYLEETQRGEQKDQGVVPPRDEISMMLLRVVESLVEQVQFFYNTSWSCRNQVGNTGNRVDQVVIGAVWGAVQKLVCTLPVEPTKVKALMEMLVGLTSDTAGDLQSVWSWVFYSMSMCARTPVFTEELSQAAKKVVKESSILRNGDHMFERHPFTMRSAVQALYAVALWVPDGVTKKGAGEKQINEGNPTHWGPAQLLADKLVKQLEQCRYKEYLADDLPMLLRALVNLTEAGILEPKEHSSALKLVENVLYYMKGLRDDGWCHRHGINVCCSLVSLGEYLLGNELVTDVVKYLASGMSVSVPENLEELRRLLRCMLSLKHSVPPAATDATTGLSSSSVTLFKAVADCILPVVVETVQRICGASKSNSTGKNISLALSVTELASKLGATLTFTFSANKVGEIVANGDLCSSRTVVELNVPALLEKVQMTAADSAHMLYLISFALSSVTVSQKMCRESKSCILRLRQAAISDKPPGSMRVETLVHLLRANAKLPVSKILFDERDLLTIMEAVCYHLTSYREKTAVLKRGGDAERVVHALVYSQVLLRLKRTLKSYAGLMETVSDILSKMEAEQTETPETLFQLRLLCDAGEIVW
Protein: Small ribosomal subunit protein uS10 (30S ribosomal protein S10) (Transcription termination/antitermination protein NusE) (P0A7R5)
Organism: Escherichia coli (strain K12)
Function: Involved in the binding of tRNA to the ribosomes. Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. In complex with NusB is involved in the regulation of ribosomal RNA (rRNA) biosynthesis by transcriptional antitermination. S10 binds RNA non-specifically and increases the affinity of NusB for the boxA RNA sequence. S10 may constitute the critical antitermination component of the NusB-S10 complex.
Interaction partners:
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein bL20
- Elongation factor G
- Small ribosomal subunit protein bS20
- Small ribosomal subunit protein bS18
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein uL6
Sequence:
MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
Protein: PIPK domain-containing protein (O01759)
Organism: Caenorhabditis elegans
Interaction partners:
- Phosphatidylinositol 4-kinase beta
- 1-phosphatidylinositol 4-kinase
- Phosphatidylinositol 4-kinase type 2
- Phosphatidylinositol 4-kinase type 2
- Rho-GAP domain-containing protein
- FERM domain-containing protein
- Phosphatidylinositol 3-kinase age-1
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphoinositide phospholipase C
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Sequence:
MASRSTTIAFKRTGDAEEEGKPPEQGDDNGEKQEAPILRPDNEAKDLPLNTLGNQTSREQQNTKEKLGHRRIDEQGGVSYKKVPTNALMQAIQLGISNSIGSLASLPNRDVLLQDFEKVDIVAFPAAGSTITPSHSFGDFRFRTYAPIAFRYFRNLFHIKPADFLRSICTEPLKELSNAGASGSIFYVSQDDQFIIKTVQHKEADFLQKLLPGYYMNLNQNPRTLLPKFFGLFCYQSLGKNIRLLVMNNLLPQTVTMHEKYDMKGSTYKRMANKAERAKPHPTLKDLDFLENHKDGIFIDPTALEALMKSISRDCLVMESFKIMDYSLLVGIHNVELGIKERAEQNRESHPAPSTSSDTFSGEKAENHKVLQEKFSVWDTGDGDVPHGGVPARNSNGDRLVLYLGIIDILQNYRLLKKMEHTWKAILHDGDTISVHNPNFYASRFLTFMTEKVFKKGTALKQSPSRRRMLKGNSHEDDSIVIVSSGHRQHRESERDGLNMTVTVTDGASTSTPRGDTTQFGSQTARESTRLYNRDSTGINEDRANSAREPPSSMSRVPLRRSYRDAGQAMSADKKEKKVERLFAQSKPTDEKVPEEQEEAEEIVSGDTPVA
Protein: Large ribosomal subunit protein eL37B (60S ribosomal protein L37-B) (L43) (YL35) (YP55) (P51402)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL22B
- Large ribosomal subunit protein eL34A
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein uL29A
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL22A
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS12
Sequence:
MGKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPSAKTRSHNWAAKAKRRHTTGTGRMRYLKHVSRRFKNGFQTGSAKATSA
Protein: 26S proteasome non-ATPase regulatory subunit 14 homolog (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (AtRPN11) (Q9LT08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome regulatory subunit RPN13
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 7 homolog A
- 26S proteasome regulatory subunit 7 homolog B
- 26S proteasome regulatory subunit 6A homolog A
- 26S proteasome non-ATPase regulatory subunit 13 homolog B
Sequence:
MERLQRIFGAGGGLGHASPDSPTLDTSEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDHVFQTNMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALNQRAVAVVVDPIQSVKGKVVIDAFRSINPQTIMLGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKNELEEKMLLNLHKKKWTDGLTLRRFDTHSKTNEQTVQEMLSLAAKYNKAVQEEDELSPEKLAIVNVGRQDAKKHLEEHVSNLMSSNIVQTLGTMLDTVVF
Protein: SD02279p (Q960G9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVPHPLAAHPHLHVPVAMHPQMQHQKEQQQQQQQLQQEQQQQDQQQSQQETPATIATNGSNQGSSNVLSAAKIAAVVAAAMATSNGNPTPTATIPASSSSSSNTLPSSNNSSCHNSSSSSNSCNSNQVPIQVPILSGSPGSTSSASHIPHVPFAYHHNLHGYLENRLEAVATPAPMDLSLGSSARRQMQLHEKDPSGVDLTFRKRKVITSPMQPDKISKLEEVIKKEPETETENEDVEVDVETEQPEEHKLPSKQVKLFKPYLLDDDEEQDHHHHHHHHRQEDLDEGAAEEEQDDEEESRYADDDEVDSKEAADKKQRRLKKKPSAINEQREPIIWSNHPYPGGCVSPGSSITSSFQCPTSMQQQQTFPVAGGSPNQQFQDNCSSSKATTPLSPFSAPALSPTGFCCPKGSPVSGYESSSSTYSDSGSNYSLNLQLHAVYNDNLMYMQQQQQQQQQQHHLQHQQHLQRWLDQESLATARTSSVNRPLILVADTAPTNLTLVA
Protein: Dihydroneopterin triphosphate 2'-epimerase (EC 5.1.99.7) (D-erythro-7,8-dihydroneopterin triphosphate epimerase) (Q9HYG7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- GTP cyclohydrolase 1 1
- Dihydromonapterin reductase
- GTP cyclohydrolase 1 2
- NAD
- Extracelullar DNA degradation protein, EddA
- GTP cyclohydrolase FolE2
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- Alkaline phosphatase H
- Dihydropteroate synthase
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Sequence:
MPRLEPGMARIRVKDLRLRTFIGIKEEEILNKQDVLINLTILYPAADAVEVNDIEHALNYRTITKAIIRHVEENRFALLERMTQEILDLVMENPAVRYAEVEVDKPHALRFAESVSITLAGHR
Protein: Guanine nucleotide-binding protein subunit gamma-e (Ggamma(e)) (Q9NFZ3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10608815}. Cell projection, axon {ECO:0000269|PubMed:10608815}. Cell projection, rhabdomere {ECO:0000269|PubMed:10608815}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit beta-1
- G protein alpha q subunit subunit alpha)
- Guanine nucleotide-binding protein subunit alpha
- G protein alpha o subunit subunit alpha 47A)
- G protein alpha s subunit subunit alpha)
- Guanine nucleotide-binding protein G
- Opsin Rh1
- G protein beta subunit 5
Sequence:
MDPSALQNMDRDALKKQIENMKYQASMERWPLSKSIAEMRSFIEENEKNDPLINAPDKKNNPWAEKGKCVIM
Protein: Autophagy-related 8a, isoform B (X2JJA8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MENRKVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNVIPPTSATMGSLYQEHHEEDYFLYIAYSDENVYGMAKIN
Protein: UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6) (O00124)
Organism: Homo sapiens (Human)
Function: Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949850}; Multi-pass membrane protein {ECO:0000269|PubMed:21949850}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- UBX domain-containing protein 2A
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- UBX domain-containing protein 1
- UBX domain-containing protein 6
- UBX domain-containing protein 4
- NSFL1 cofactor p47
- Small VCP/p97-interacting protein
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Nuclear protein localization protein 4 homolog
Sequence:
MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLIISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN
Protein: Cytochrome c oxidase subunit 3 (Q8HCR6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Heme O synthase
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Os04g0343050 protein
- Cytochrome c oxidase subunit 1
- Cytochrome b
- Cytochrome b
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome b6
Sequence:
MGVKGGLHTTGAKWFMIESQRHSYHLVDPSPWPISGSLGALATTVGGVMYMHSFQGGATLLSLGLIFLLYTMFVWWRDVLRESTLEGHHTKAVQLGPRYGSILFIVSEVMFLFAFFWASSHSSLAPTVEIGGIWPPKGIGVLDPWEIPLLNTPILPSSGAAVTWAHHAILAGKEKRAVYALVATVSLALVSTGFQGMEYYQAPSTISDSIYGSTFFLATGFHGFHVIIGTLFLIVCGIRQYLGHLTKKHHVGFEAAAWYWHFVDVVWLFPFVSIYWWGGI
Protein: Guanine nucleotide-binding protein subunit alpha (A0A1D8PJG1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Gpr1p
- Adenylate cyclase
- G protein subunit beta
- GTPase-activating protein
- Phosphodiesterase
- Ras-like protein 1
- Ras2p
- Cell division control protein 25
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
Sequence:
MGSCASKSADQGNGTSKQQQSAQSTQGKRQQQSQAIQQKNKEKQQSRQKEQQEKHQQQQQQQPQPQSPSDSNADGTLKNGSDFYETLKHPSDSSNDNGHLKENHSQDLSNGTANKNLITNPVDAAGNSNPSKDVKVLLLGSGESGKSTIVKQMKILHSDGYTQDELEEYRPFVYKNILDCIKNVINAIIDLQPDLIRKPDSPQLEEDHEEDLKVTGLTSENNHVPTANGSVTNQPPPPPKQRKHILEYDMLNEILDYDYPLNLNQQFDPDIAIKIKKVYETPEVKEFMLQRQGDFYLIDSTDYFLSNLDRICLAGNYEPNVTDVLRTRKKTSGIFIYTFDLGNGLNMNLFDVGGQRSERKKWINCFDNVSTIIFCVALSEYDNFLLEESNTNRLEESLALFDSVVNSRWFSRTTVVLFLNKIDVFAEKLKYSPLENFFPDYKGGSNISNGVKYILWRFNKLNRSGLNIYPHVTQATDTSNIELVMAAVKQTILENSLKDSGIL
Protein: Large ribosomal subunit protein eL31 (60S ribosomal protein L31) (P62902)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62899}.
Interaction partners:
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL36
- Large ribosomal subunit protein eL32
Sequence:
MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN
Protein: phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) (F1NHX1)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Uncharacterized protein.
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
- GTPase HRas
- Uncharacterized protein
- Uncharacterized protein.
- Insulin receptor substrate 4.
- Insulin receptor substrate 1.
Sequence:
MPPGIYCPMEFWSKGENQNIQVDFLLPTGIYLNLSVPCNASLDTIKQVVWKHAQYEPLYHMLSDPEAYVFTCINQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSVQDPEVNDFRTKMCQFCEERAAKRQQLSWAAWMEYNFPLQLEPMAKGLGTGLLHTPIKNIFVNVKFQSGGESFTFQISPNEFPITLMSYAVKKQATVFRHETMENPEDYTLQVNGKYEYLYGNYPLYQFQYIRSCLHRGLTPHLTMVHSSTIIAMRDEQVNSIANPPKMAVKPPPLPKKKPNYGSLWSLEQSFYIELVQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLDFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWVNVMLFDYKDQLKTGECCLHMWSSFPDEKGELLNPMGTVQCNPNTESAAALVICFPNVASHPVYYPSFEQLLELGRNGEQPRSAPEDPEEKLQLKEILERRNHTELYEHEKDLVWKMRYDIRDQYPQALAKLLTITKWNKHEDVAQMISLLQTWPELPVLNALELLDFSFPDRYVGSFAINSLKKLTDHELFQYLLQLVQVLKYESYLDCELTKFLLDRALSNRKIGHFLFWHLRSEMHVPAVALRFGLILEAYCRGSTHHMKVLMKQGEALSKMKALNEFVKLSSPKATKPQAKEMMHVCMKQETYLEALSHLQSPLNPSIILTEVCVDQCTFMDSKMKPLWIVFNNEETGGGGVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDKTGLIEVVMHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGDALEQAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRETGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCEKAYMILRRHGPLFLHLFALMKAAGLPELTCSKDIQYLKDSLALGKTDEEALKHFRLKFNEALRESWKTKVNWLAHNVSKDNRQ
Protein: Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) (Q99873)
Organism: Homo sapiens (Human)
Function: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP and MAP3K5/ASK1. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity. Methylates MAP3K5/ASK1 at 'Arg-78' and 'Arg-80' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner. Plays a role in regulating alternative splicing in the heart (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:16879614}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9JIF0}. Cytoplasm {ECO:0000269|PubMed:26876602}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JIF0}. Lysosome membrane {ECO:0000269|PubMed:38006878}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). Upon methionine stimulation, localizes to the lysosome membrane in an NPRL2-dependent manner (PubMed:38006878). {ECO:0000250|UniProtKB:Q9JIF0, ECO:0000269|PubMed:38006878}.
Interaction partners:
- Histone H4
- Histone acetyltransferase p300
- Protein arginine N-methyltransferase 5
- Protein BTG2
- Histone-arginine methyltransferase CARM1
- Methylosome protein WDR77
- Enhancer of rudimentary homolog
- RNA-binding protein FUS
- Runt-related transcription factor 1
- KH domain-containing, RNA-binding, signal transduction-associated protein 1
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR