wanglab/gogpt-training-data huggingface dataset:
Protein: S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (Methionine adenosyltransferase) (MAT) (Q54F07)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Interaction partners:
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Methionine synthase
- S-adenosylmethionine decarboxylase proenzyme
- Tyrosine aminotransferase
- methylenetetrahydrofolate reductase
- Methionine adenosyltransferase regulatory beta subunit
- Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein
- Spermidine synthase
- Adenosylhomocysteinase
- GAF domain-containing protein A
Sequence:
MSSYLFTSESVTEGHPDKICDQVSDAVLDACLAQDPLSKVACETATKTGMVMILGEITTKANVDYQKVVREAVKKIGYDDSSKGFDYKTCNVLVAIEQQSPDIAQGVHIGKVNPEDIGAGDQGHMFGYATNETPTLMPLTHFLASELVNKLTELRHNGTLAWARPDAKTQVTVEYKKEGHKITPVRVHTIVISTQHDEKVTNEQIRADLKELVIKAVVPAQYLDDNTIYHLNPSGRFVIGGPMGDSGLTGRKIIIDSYGGWGAHGGGAFSGKDATKVDRSGAYAARWIAKSLVAAGLADRCLVQVSYSIGVAKPLSVFVDTYGTGKKTDAEILAIIDNNFDLRPGCLMRDLQLTRPIFQKTASGGHFGRNDPDFTWETVKELKM
Protein: S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] (P17708)
Organism: Rattus norvegicus (Rat)
Function: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Interaction partners:
- Spermidine synthase
- Spermine synthase
- S-adenosylmethionine synthase isoform type-2
- S-adenosylmethionine synthase isoform type-1
- Ornithine decarboxylase
- Antizyme inhibitor 2
- DNA
- Methionine adenosyltransferase 2 subunit beta
- DNA
- DNA
Sequence:
MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDLPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQS
Protein: Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen homolog] (Q07563)
Organism: Mus musculus (Mouse)
Function: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
Subcellular location: Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome. {ECO:0000250}.; SUBCELLULAR LOCATION: [120 kDa linear IgA disease antigen homolog]: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Interaction partners:
- Dystonin
- Plectin
- CD151 antigen
- Integrin beta-4
- Integrin alpha-6
- Keratin, type II cytoskeletal 5
- Laminin subunit alpha-3
- Class E basic helix-loop-helix protein 23
- Keratin, type I cytoskeletal 14
- Laminin subunit gamma-2
Sequence:
MDVTKKSKRDGTEVTERIVTETVTTRLTSLPPKGSTSNGYAKTGSLGGGSRLEKQSLTHGSSGYINSSGSIRGNASTSSYRRTHSPASTLPNSPGSTFERKAHMTRHGTYEGSSSGNSSPEYPRKELASSSTRGRSQTRESEIRVRLQSASPSTRWTELDEVKRLLKGSRSASASPTRNTSNTLPIPKKGTVETKTVTASSHSVSGTYDSAILDTNFPPHMWSSTLPAGSSLGTYQNNITAQSTSLLNTNAYSTGSVFGVPNNMASCSPTLHPGLSSCSSVFGMQNNLAPSSSVLSHGTTTASTAYGAKKNVPQPPTVTSTGVSTSATCTTSVQSDDLLHKDCKFLILEKDNTPAKKEMELLIMTKDSGKVFTASPATISSTSFSEDTLKKEKQAAYAADTCLKADVNGDLNTVSTKSKMTSAENHGYDRGGGGGRGKGGGAGGGGGGGGASGGGGAWGAAPAWCPCGSCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRKLKARVEELEKTKVLYHDVQMDKSNRDRLQAEAPSLGPGLGKAELDGYSQEAIWLFVRNKLMTEQENGNLRGSPGPKGDMGSQGPKGDRGLPGTPGIPGPLGHPGPEGPKGQKGSIGDPGMEGPIGQRGLAGPMGPRGEPGPPGSGEKGDRGIAGEQGPQGLPGVPGPPGLRGHSGSPGPQGPPGAVGPQGLRGDVGLPGVKGDKGLMGPPGPKGDQGEKGPRGLTGEPGIRGLPGAVGEPGAKGAMGPAGADGQQGSRGEQGLTGMPGTRGPPGPAGDPGKPGLTGPQGPQGLPGSPGRPGTKGEPGAPGRVMTSEGSSTITVPGPPGPPGAMGPPGPPGTPGPAGPAGLPGQQGPRGEPGLAGDSFLSSGSSISEVLSAQGVDLRGPPGPPGPRGPPGPSIPGPPGPRGPPGEGVPGPPGPPGSFLTDSETFFTGPPGPPGPPGPKGDQGDPGVPGTPGISGGLSHGASSSTLYMQGPPGPPGPPGPPGSLSSSGQDIQHYIAEYMQSDNIRTYLSGVQGPPGPPGPPGPVITITGETFDYSQLASQVVSYLRSSGYGAGLSSASSSEDILAMLRRNDVWQYLRQNLVGPPGPPGPPGVSGDGSLLSLDYGELSRHILNYMSSSGISFGHPGPPGPPGLPGTSYEELLTMLRGSDYRNIIGPPGPPGPPGMPGNAWSSISVEDLSSYLHTAGLSSIPGPPGPPGPPGPRGPPGVSAALSTYAAENSDNFRSELISYLTSPDVRSFIVGPPGPPGPQGPPGDGHLRENYNWSSNSSARRGTSYSSSTGTGGTNGGSLGEGGAYGAGDGGPYGTDIGPGGGYGAAAGGGIYGTNGDSFRDGFTGDLDYNKLAVRVSESMQRQGLLQGMAYTVQGPPGPQGPPGISRVFSAYSNVTQDLMDFFQTYGTIPGPPGQKGDVGTPGPKGDRGPAGPRGPPGPPGPRGNKGEKGDKGDQVYTGRRKRSIAIKP
Protein: ATP-dependent DNA helicase 2 subunit KU70 (EC 3.6.4.12) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (Q9FQ08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand.
Subcellular location: Nucleus {ECO:0000269|PubMed:12148535}. Cytoplasm {ECO:0000269|PubMed:12148535}. Note=Predominantly in the nucleus.
Interaction partners:
- DNA ligase 4
- ATP-dependent DNA helicase 2 subunit KU80
- DNA ligase 6
- DNA repair protein XRCC4
- Telomerase reverse transcriptase
- DNA repair protein RAD50
- Double-strand break repair protein MRE11
- DNA polymerase lambda
- DNA ligase 1
- DNA-repair protein XRCC1
Sequence:
MELDPDDVFRDEDEDPENDFFQEKEASKEFVVYLIDASPKMFCSTCPSEEEDKQESHFHIAVSCIAQSLKAHIINRSNDEIAICFFNTREKKNLQDLNGVYVFNVPERDSIDRPTARLIKEFDLIEESFDKEIGSQTGIVSDSRENSLYSALWVAQALLRKGSLKTADKRMFLFTNEDDPFGSMRISVKEDMTRTTLQRAKDAQDLGISIELLPLSQPDKQFNITLFYKDLIGLNSDELTEFMPSVGQKLEDMKDQLKKRVLAKRIAKRITFVICDGLSIELNGYALLRPAIPGSITWLDSTTNLPVKVERSYICTDTGAIMQDPIQRIQPYKNQNIMFTVEELSQVKRISTGHLRLLGFKPLSCLKDYHNLKPSTFLYPSDKEVIGSTRAFIALHRSMIQLERFAVAFYGGTTPPRLVALVAQDEIESDGGQVEPPGINMIYLPYANDIRDIDELHSKPGVAAPRASDDQLKKASALMRRLELKDFSVCQFANPALQRHYAILQAIALDENELRETRDETLPDEEGMNRPAVVKAIEQFKQSIYGDDPDEESDSGAKEKSKKRKAGDADDGKYDYIELAKTGKLKDLTVVELKTYLTANNLLVSGKKEVLINRILTHIGK
Protein: Cytochrome b5 (A8WGS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}. Microsome membrane {ECO:0000256|ARBA:ARBA00037877}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037877}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037877}.
Interaction partners:
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase 2
- Membrane-associated progesterone receptor component 1
- Neuferricin
- Membrane-associated progesterone receptor component 2
- Cytochrome b5 reductase 4
- Lanosterol 14-alpha demethylase
- Adrenodoxin, mitochondrial
- Sulfite oxidase, mitochondrial
Sequence:
MANNGTDGKGVKYYRLSEVEERNSFKSTWIIIHNKVYDVTKFLEEHPGGEEVLREQAGGDATESFEDVGHSTDAREMASSMLIGEVHPDDRDKIAKPPESLVTTVQETTSWWSNWLIPAVAAVIVTLMYRIYTAEEA
Protein: glutathione transferase (EC 2.5.1.18) (Q6PFJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAMKLAYWDIRGLAQPIRLLLEYTGTKYEEKFYTCGEAPNYDKSCWFNEKSKLGMDFPNLPYLEDGDRKIVQSNAIMRYIARKHNLCGETEEEQMRVDILENQAMDFRNGFVQLCYLDFDKNKSSYCEKLSGTLKQFSDFLGDRKWFAGDKITFVDFIMYELLDQHRMFEPACLDDFKNLRCFLDHFESLEKIAEYMKSNRFMETPVNNKMAKWGNKKE
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) (Q68SA9)
Organism: Mus musculus (Mouse)
Function: Metalloprotease that may play a role in the degradation of COMP.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15192113}. Note=Also found associated with the external cell surface.
Interaction partners:
- Cartilage oligomeric matrix protein
- Progranulin
- A disintegrin and metalloproteinase with thrombospondin motifs 12
Sequence:
MHRGPSLLLILCALASRVLGPASGLVTEGRAGLDIVHPVRVDAGGSFLSYELWPRVLRKRDVSTTQASSAFYQLQYQGRELLFNLTTNPYLMAPGFVSEIRRHSTLGHAHIQTSVPTCHLLGDVQDPELEGGFAAISACDGLRGVFQLSNEDYFIEPLDGVSAQPGHAQPHVVYKHQGSRKQAQQGDSRPSGTCGMQVPPDLEQQREHWEQQQQKRRQQRSVSKEKWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHISIVRLIILEDEEKDLKITHHAEETLKNFCRWQKNINIKGDDHPQHHDTAILLTRKDLCASMNQPCETLGLSHVSGLCHPQLSCSVSEDTGMPLAFTVAHELGHSFGIQHDGTGNDCESIGKRPFIMSPQLLYDRGIPLTWSRCSREYITRFLDRGWGLCLDDRPSKDVIALPSVLPGVLYDVNHQCRLQYGSHSAYCEDMDDVCHTLWCSVGTTCHSKLDAAVDGTSCGKNKWCLKGECVPEGFQPEAVDGGWSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACPPDRPSFRHTQCSQFDGMLYKGKLHKWVPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRDICLNGICKNVGCDFVIDSGAEEDRCGVCRGDGSTCQTVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWNGDYRVAGTTFTYARKGNWENLTSPGPTSEPVWIQLLFQEKNPGVHYQYTIQRDSHDQVRPPEFSWHYGPWSKCTVTCGTGVQRQSLYCMERQAGVVAEEYCNTLNRPDERQRKCSEEPCPPRWWAGEWQPCSRSCGPEGLSRRAVFCIRSMGLDEQRALELSACEHLPRPLAETPCNRHVICPSTWGVGNWSQCSVTCGAGIRQRSVLCINNTDVPCDEAERPITETFCFLQPCQYPMYIVDTGASGSGSSSPELFNEVDFIPNQLAPRPSPASSPKPVSISNAIDEEELDPPGPVFVDDFYYDYNFINFHEDLSYGSFEEPHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPPGLEQTSINPLANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTSPALPQSPIPTQPSPPSISPTQASPSPDVVEVSTGWNAAWDPVLEADLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKTLTMPGTLLLTVPTDLRSPGPSGQPQTPNLEGTQSPGLLPTPARETQTNSSKDPEVQPLQPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAIWRLVSCSSGNDEDCTLASRPQPARHCHLRPCAAWRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCQPGPTKPPNRQLCGTQPCLPWYTSSWRECSEACGGGEQQRLVTCPEPGLCEESLRPNNSRPCNTHPCTQWVVGPWGQCSAPCGGGVQRRLVRCVNTQTGLAEEDSDLCSHEAWPESSRPCATEDCELVEPPRCERDRLSFNFCETLRLLGRCQLPTIRAQCCRSCPPLSRGVPSRGHQRVARR
Protein: Exoribonuclease II (EC 3.1.27.1) (C0H520)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Exosome complex exonuclease RRP6
- Exosome complex component CSL4, putative
- Exosome complex component RRP45, putative
- Exosome complex component RRP40, putative
- Exosome complex component RRP4
- Exosome complex component RRP41
- Exosome complex component MTR3, putative
- ATP-dependent RNA helicase SUV3, putative
- Ribosomal RNA-processing protein 42
- ATP-dependent RNA helicase, putative
Sequence:
MFFFKNVQRYCFYRRIYENIQIIRALQIKEKAKNNVTKRREEWWDNNVNKNDRNMCRSKNYLSGCTTRDDNMKDDNMKDGNMKDDNMKDNNMKGRNTKCDNIKDNNMKGRNTKCDNIKDNNMKGRNTKCDNIKDNNNDNNSINNNSINNNSINNNSINNNSINNNSINNNSINNNSINNNNIKDKDEKHFYKNIFSELKKVNDKCTKKYVPVDEKNIKSVTNEDHLSKKNILENEKKDAHFSFTHDEGNNKEEIKNDNIRIIPQSIPSNDVYNISKQKKGQCKNNETKEKYLKEKNKYLVRKDIYLKVKNEHINNKELLRKKEIYSKRDMNKNNKSKMKKIIKEKNEEIFIKKNDKDKISQLDIINKNKGTKNMDNRKNYLIVKNGNISSNNKMDYLLSNNNNNNNNNNKNNNKVLFNNGKKINNIEGEQKDDINNSQTHNYKNKDVSNKIIISSQNSFLPNVEKNNIFVEYETHWDNDKIKEMLELQKDTKILKNYLFKGVLYISPFDTNKCFVISKETNGLMKCKLYSVYGYISRNRALNDDVVYAYTERRTIKNENVSNMEINIEVEKDKYESRDNIEHVKNQYNEKEDNNNEKNEEIEKGKFCRVVKIVERKNVEVVGSLNYLNIKEKINNIFGKKSKFNKNKKKNENCYIELDDNNIGNNMVDDVFKYNNHDDINNNNNNNNNILHSSNIFHLLNEKNNYVYAKVQPTDSRLPCFIYDSSNNITNMLLNYIRREKLNVYVIVKFKEWEKKQINPIGNITTILGNENNFFGIIYLFLYLYKIHYYIYKITDMNYLKSQIVISDKIMNSFINRKNHMEQLLLLLNGYNKEKEYSIQEINKKIAYLKNAQKEKKMLEKYMLKSFLSNRYIITDLDIFTIDPTKAKDLDDALSIEFIKDNKEQHELKYRYKIGIHISDVSFFVTPNSYYDNLASKICNTVYMDFTVFHMLPSILSEEICSLNTKGEKLAFSIFFYVDNISNPYNITQMEYAGYEKNPHLIEIKKTLIRSKYKLNYDMVEDYIEDIYINIKEKDKDINSIEEMILINGNISLSYFIFNFDDICKKYNISEKIGGDIFRLYLLSKMLKQKTKRKNIYQKYSLLFSLNNNKKNNSEKILPLSIEPLSNKYLSKVRNIDDINNKNNMYKSFNQFLIDEGYYKLLEPMNLKNVDIEILEYKKRSHMLIEEMMILTNFLVANVISINNMLGILRIHEDTSEDIKKNLLKIIDYQTYNKINTMINIKNNNINDILSVSQKVLNENQFLCLQYNLLKYYKEAIYIPTVEGQNNTTHFGLVLNKYIHFTSPIRRYIDIVIHRILQSLIDQDNIGYYNYDMLKNICDQCNYQKKKSDEAQIHMKNYFLNKYLIYLNDIYKKVIQNHRMNGYYSVHGNNENNIDENNDKINNIDEKNDKINNIDEKNNKINNIDEKNNQLSNNYIHLEDENKKLYNPSNKNVQRTDHISLSTYKEILYMSNYMPIKKYFYLNNGIISFLTEAYIQEIIITKSIRENICINIVKENYISINENYSNEIIPYTCYICNDFPHKDIEKDYIRNDNLNNDNSLFNSQMDNNENETNVETLFKKSINENNKLKNAIVFYVPILEIEKSISDNLLSLKFHFLIISYKEKIYIYNILKGVLYEMCSNILLGRNEKNNNDIYDDDINLEDEYKKNKQLYDIFEKIKHIQLDIKYKMESVENKKDFQNVYDGLYIHDVLIEKNKNEKGEENKSNILTYKKNTTINNISNEQNYINNVGKDESEYLKCLNDKKLEYKYYNSYEKLSRFQKNKVFIIPGSQMWTLRLI
Protein: LIM domain-containing protein PLIM2a (Pollen-expressed LIM protein 2) (AtPLIM2) (O80839)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to actin filaments and promotes cross-linking into thick bundles. Has an actin-stabilizing activity. The actin regulatory activities are inhibited by pH > 6.8 but are [Ca(2+)] independent.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20817848}.
Interaction partners:
- LIM domain protein
- Uncharacterized GPI-anchored protein At5g19230
- Uncharacterized GPI-anchored protein At5g19240
- Fimbrin-5
- Protein DA1-related 7
- Propionyl-CoA carboxylase
- Actin cross-linking protein, putative
- Uncharacterized GPI-anchored protein At5g19250
- Uncharacterized GPI-anchored protein At3g06035
- Protein DA1-related 1
Sequence:
MSFTGTLDKCKACDKTVYVMDLLTLEGNTYHKSCFRCTHCKGTLVISNYSSMDGVLYCKPHFEQLFKESGNYSKNFQAGKTEKPNDHLTRTPSKLSSFFSGTQDKCATCKKTVYPLEKVTMEGESYHKTCFRCTHSGCPLTHSSYASLNGVLYCKVHFNQLFLEKGSYNHVHQAAANHRRSASSGGASPPSDDHKPDDTASIPEAKEDDAAPEAAGEEEPEPVVES
Protein: Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) (Q04752)
Organism: Bos taurus (Bovine)
Function: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Nuclear receptor subfamily 0 group B member 1
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Nuclear receptor subfamily 0 group B member 2
- Forkhead box protein L2
- Steroidogenic acute regulatory protein, mitochondrial
- Catenin beta-1
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cholesterol side-chain cleavage enzyme, mitochondrial
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPVGVPPPPPPPPDYMLPHGLHASEPKGLASGPPAGPLGDFGAPALPMAVPSAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGPPYGYPEPFSGGPGVPELILQLLQLEPDEDQVRARIVGCLQEPAKGRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQIQHGKEGSILLVTGQEVELTTVAAQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKEAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
Protein: Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42) (Q8IZL9)
Organism: Homo sapiens (Human)
Function: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
Subcellular location: Nucleus {ECO:0000269|PubMed:14597612}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Cyclin-H
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIH subunit 3
- Transcription initiation factor IIE subunit beta
- General transcription factor IIE subunit 1
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG
Protein: Putative zinc metalloproteinase YIL108W (EC 3.4.24.-) (P40483)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Uncharacterized protein YER034W
- Uncharacterized protein YCR001W
Sequence:
MVGSKDIDLFNLRENEQIVSPCLIVHGKCNKQNGAKTVQVQHPQLPPITYPIHNQFFKATVILTPGENKLTFVTDTNTARTIVCYYTPLTQNPPVHLCLILAKDSPLQFDSPREQKDREGGNGLELAIKKLRLGARLMQAYTNEQMLRNSMGNRTFPFVEEFTWDTLFERPAMRNTIKIHVVRSEKTVKEIQDPDIAQQNSKGKNTGALFGIAMDALKSYGGPFTNNEKPVQAACMFLDTHWDGKLIRGHAALGGGDDSIKLAIFGSHGLYSWPTCLEQLVPYFTDETRSSTSEVANDCNECGTYWECLTITLGAFMHEIGHLLGCPHQESGVMLRGYTTLNRSFLTKEAYSVRTNSTGASPPIFPKEECTWNRLDTVRFLYHPSFTLPQDYYDPSFMRPTKLGGYPNIKHSVYPLGNGSCRILSPTGIYLIEIICDDLARGHIEYLPVSLGGQGPQREVIVTLDDLRARLPKNELAKFGNTFKLKILSVNAPETEFDKFPSLLDVQPLDMSKYGFSKNVQGIKSPLYGRSDGGNAVGVVAFDVRLVTAVRIYHGYALDGVRFYYKEKPTGTKDAPASKPSVPPRNYFSKITHSIKNHASINEENLKSVLFGHETQNFTDATLEPGEIIIGFNLRCGAWVDAIQIITSHGRMTDMFGNKDGGGFAELQPPNGQYILGVTGRVGQWVDAFGIIYGAL
Protein: Cutinase (EC 3.1.1.74) (A0A0F9X9J5)
Organism: Trichoderma harzianum (Hypocrea lixii)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU361263}.
Interaction partners:
Sequence:
MRSLAIFTAILAGHAFAYPKPVSQSPSRRDWPSINEFLSELAEIMPIGDTVSAACDLIGDAEDVAADLFDISNTENDACGDVTVLFARGTCDPGNVGVLVGPWFFKSLETALSNKRVGVKGVPYPASVQGFLSGSVQPGIDMANQIKSVISSCPNTKLVLGGYSQGSMVVHNAASNLDAATMAKVSAVVLFGDPYNGRPVANYDASKVLVVCHDGDNICQGGDFILLPHLTYAEDADTAAAFVKPLVS
Protein: Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3) (Q923M0)
Organism: Mus musculus (Mouse)
Function: Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Interaction partners:
- DnaJ homolog subfamily C member 7
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
Sequence:
MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAHSKKGHGERPWKEVAGLRPRKHVLFPPSVALLEAAARNDLEEVRQFLTSGVSPNLANEDGLTALHQCCIDDFQEMAQQLLDAGADVNARDSECWTPLHAAATCGHLHLVELLISRGADLLAVNSDGNMPYDLCEDAQTLDCLETAMANQGITQEGIEEARAVPELCMLNDLQNRLQAGANLSDPLDHGATLLHIAAANGFSEVATLLLEQGASLSAKDHDGWEPLHAAAYWGQVHLVELLVAHGADLNGKSLVDETPLDVCGDEEVRAKLLELKHKQDALLRAQGRQRSLLRRRTSSAGSRGKVVRRVSLTHRTNLYRKEHAQEAIVWQQPPPTSPEPLEDEDRQTDAELRLQPPEDDGPEVARPHNGQVGAPPGRHLYSKRLDRSVSYHLSPEENSAPDALVRDKAHHTLAELKRQRAAAKLQRPAPEGPETFEPGLSVDAGTSQPDCGFSTIGDPPLLKLTAPSEEASVEKRPCCLLM
Protein: Myosin-12 (Myosin XI F) (AtXIF) (F4IRU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
Interaction partners:
- Serine/Threonine-kinase ULK4-like protein
- Uncharacterized protein At1g01500
- Pentatricopeptide repeat-containing protein At4g39530
- Fimbrin-1
Sequence:
MGTPVNITLGSHVWVEDPELAWISGEVTEIKGTNAKIVTANGKTVVASISSIYPKDTEAPPAGVDDMTKLAYLHEPGVLHNLDCRFALNEIYTYTGNILIAVNPFQRLPHLYSVHMMEQYKGAAFGELSPHLFAVADTSYRAMINEARSQSILVSGESGAGKTETTKMLMRYLAFMGGRSDTEGRSVEQQVLESNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDKRGKISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPPEEAKKFKVGDPRTFHYLNQTNCYEVSNVDDAREYLETRNAMDIVGIGQEAQDAIFRVVAAILHLGNVNFIKGEEADSSKLRDDKSRYHLQTAAELLMCNEKMMEDSLCKRVIVTPDGNITKPLDPESAASNRDALAKTVYSRLFDWIVDKINSSIGQDPDAKSLIGVLDIYGFESFKINSFEQLCINLTNEKLQQHFNQHVFKMEQEEYTREEINWSYVEFVDNQDVLDLIEKKPGGIIALLDEACMFPKSTHETFAQKMYQTYKGHKRFSKPKLAQTAFTVNHYAGDVTYSAEQFLDKNKDYVVAEHQALLDASKCSFVANLFPPLPEDASKQSKFSSIGTRFKQQLQALMETLNTTEPHYIRCVKPNAVLKPGIFENDNVLNQLRCGGVLEAIRISCAGYPTKRAFDEFLDRFVMLATDVPEGSDEKSACASICNKMGLKGYQIGKTKIFLRAGQMAELDARRTEVLAGATKLIQRQIRTYLTRKEFLGQKRATIYMQKLWRAKLARKLYQNMRREAASICIQKNIRAHRARKNYTKLQASATVIQTGLRTMSARNKHRHRRRTKAAIIIQREWRRHQVHEAYKKHKKATLALQCLWRAKVARKELKNLRMAARETGALKEAKDKLEKRVEELTWRLELEKNQKADLEDAKAQEIAKLQNNLTELQEKLDEAYAAIIRDKEAAKLAIEQAPPIIKEVPVVDNTQLELLNSQNNELEVEVAKLKGKIKEFEVKCFALENDSRASVTEAEDAKSKAVEFQEIIERLHTNLSNLESENQVLRQQALAASTSVEEIGELNSLKDKVAILESENETLRRQTESAEKTMPPARVFASEKNLENEHQTKEIQATKEPRNPINVLAKQGSLTDRQQESHEVLMKCLTDERRFDNEKSVAAWIVYKALLQWRLFEAEKTNIFDRIVHKIRSSIEGQDDTRELAYWLTTSSTLLYLLQSTLKFSNTNNAASRRNRSSHATLFGRLVQGMQPSSVGLETSSGYSGMAGIPNDQQMVEAKYPALLFKQHLAAYVEKTYGMIRDKLKKEINPLLNLCIHAPRPTRAKTLRDVTKSIHLTTIAKQQASYVQWQNIVNKLEHTLTFMAENHVPSMITRKLFHQVFSYINVQLFNSLLLRRECCSVSNGEYLKMGLHELEQWCLKADDEATRSPWDELQHIRQAVMFLVSHQKTQKSLDEIAKEICPVLSIPQVYRIGTMFWDDKYGTQGLSPEVINQMRKLMTEDSANMTYPSFLLDVDSSIPFSVEDVSQSFHGGNISLSDVDPSPLLRQRSDFHFLFQTLPE
Protein: Saposin B-type domain-containing protein (Q86B07)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Saposin A
Sequence:
MKSVFVLLFIVLSVLINFTTAVNIPVNGKSLEIKNKFEEFISNDVKSANGGTHCAACTIVLSLVNQYSGIHNKSIEDSLDELCSFFPDEAGSLCTWLVNTYGEQIISYFDQYQNADDVCHAMNVCTSPTCRLFTSAPSKFYNPDHVHQEYNKEDPKVGGSPWAWIQELIKVFSSEHLPIQDFDGDHHSLEATFRGYNWRGKDCNDFDKSSYPGTIEGTGDASVDKNCNGIFGVNNQSQSYEELFCSNSGAMGVIVSGDSAGAHFSIPPQWMTARDINSTTYKGMIDILETEVDWPMRSCYTGWDTSAPNVDSMYLRMRERNLCNHRDYQNLGVNGASSSSTRTIIQTINRNQNTDKPVLLFLELIGNDVCSGHHDYDSMTTVEEFGENILTILNYLETTLPKGSHVVFVGLADGRVLWDSLWNRTHPLGCTYEEVYDFLNCIQVSPCWGWMNPNETVRDYTSNRAAQLSLVYNQLIKNYTFNNFDMIYYDFPFATINEMWVAQGGQTYDLIEPIDGFHPNQIANYLMAGVFYNQIAQDKPEWLGEINQYNTQIQSIFGNQGGYV
Protein: Large ribosomal subunit protein uL2A (60S ribosomal protein L2-A) (K37) (K5) (KD4) (P0CT70)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL3A
- Small ribosomal subunit protein uS17A
- Large ribosomal subunit protein uL30B
- Elongation factor 3
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL18A
- mRNA export factor elf1
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL14
Sequence:
MGRVIRAQRKSGGIFQAHTRLRKGAAQLRTLDFAERHGYIRGVVQKIIHDPGRGAPLAKVAFRNPYHYRTDVETFVATEGMYTGQFVYCGKNAALTVGNVLPVGEMPEGTIISNVEEKAGDRGALGRSSGNYVIIVGHDVDTGKTRVKLPSGAKKVVPSSARGVVGIVAGGGRIDKPLLKAGRAFHKYRVKRNCWPRTRGVAMNPVDHPHGGGNHQHVGHSTTVPRQSAPGQKVGLIAARRTGLLRGAAAVEN