wanglab/gogpt-training-data huggingface dataset:
Protein: Sop-2-related protein 1 (P34619)
Organism: Caenorhabditis elegans
Function: Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:16501168}. Note=Forms subnuclear bodies. Sop-2 is required for nuclear localization.
Interaction partners:
- Polycomb protein sop-2
- F-box domain-containing protein
Sequence:
MTINIKYSSKFSSSKTSSSEELKPKTYIPAYYQPPVSMPKYYVNWLRIKLSLNKLKNIRAIYLFDQCQNFNQYQESSRKFSAGQVSSLTPWYSNFSNYSTVILRMKDTSLPPLENPSNGGTYLFNLITVFPSIALSFNYSWRGDTGPSISIFSFSLSVLFFSLFPQHKNICARAWCRPFRRSLSFSLRFIMSSEPASSSTEKVPEEPHPHSIKHKFQGPQFVIPRALSDYVLNVNNQTPESYEKALNAKYGRDDYITLCLHVTSLCTEYGPLDDGPEYVLLCDSRARVDKLIEDLVKLLEIDTDYVQLELHGGKRLHLQKPDAVLRDIAYKQSNEGSDKFFLEMKLVPSESMKAKIMKQEEEEEKARKHGQYQQYQEYHQQHQAMNDGQSSSSVPSTSSPSCSSEANRKEMETVREPAGPSELMRAINAPVAPAPVVIKIETPVALPEEDETLMDDDEMPSLTVEAPSEEASFEAEQPSPQVPQASIEGPSQQQQIPGTSQQKRQVARGSRTNMISYHDLPPGTGNAPPMACPQVTLKLEKNVPFEAKIRAVAGYTRKPISEVQKMRPSDLESIFHSICIASVQRIKRRNELVQQLQEINAQSCKSPTMTMNKKFTLAKAYQRVQNEIEKIDREQILPQQYMNMPPMPPQGQQRLPPPAYPPGILPPQQNRQQGVPPQFQRSPQFMIGPDGQRYAHPYMQLPNSNQRARILNTSSVQPSEEVRNRLVKIEAMAMNMAQLNPPRPPPPQPPHRALQGELQFLRPGAPDPCNFRPDSKQTYNNTYVTVASPATLTNSIIPWHFPPYEKSGRLNVSNTIKAINEYRLLCNSRQADPASFLEFYFLGDPMPHFNKILSIADYNMYLSRRRCDEADVKIHRMSHSDQLQLYLLELQSDESNVEKWKTFYRIMQWDLPLNNEFPRILLPSSLDIGRPVVDRKKKSIDQVMNHIHRMHSQRPPSMGNSSTSSEASSTSPTNAATATSSPASNRPTTSTAQPPTLNPT
Protein: Complement C1q subcomponent subunit B (P02746)
Organism: Homo sapiens (Human)
Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Subcellular location: Secreted.
Interaction partners:
- Complement C1q subcomponent subunit A
- Complement C1q subcomponent subunit C
- Complement C1s subcomponent
- Complement C1r subcomponent
- Plasma protease C1 inhibitor
- Complement C4-A
- Complement C4-B
- Complement C2
- V-set and immunoglobulin domain-containing protein 4
- Calreticulin
Sequence:
MMMKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA
Protein: Interleukin 7 receptor (Interleukin-7 receptor subunit alpha isoform X1) (Interleukin-7 receptor subunit alpha precursor) (E9QDP8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Fibronectin type-III domain-containing protein.
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase
- Chemokine
- CD4-1 molecule
- Protein tyrosine phosphatase receptor type C.
- IKAROS family zinc finger 1
- Tyrosine-protein kinase
- V
- Interleukin 2 receptor beta
Sequence:
MAGLLWIIFVVFCPLGLSESGDGDLPDKEVTCTSTLTLMQNILYCFPNDEPIEEVIFATLCKMKEKSKCTNATLGPKYFSFENLENIVKYELQVHLRDGIIEKEIDLTKMVKIPAPELKSATFLKETDEIFIWFEHRHDYVRQCQFQVEIRGEHEPISLLVDYKNISMSRDRLGGDGVYSTRVRAKPINYFAGDWSEWSSDANFTIKTKNHAPIQTPQVVTGILTIILVLIISLIALRWRTQIKKYITPNIPHPKATLAQMQRAKEGLPFTFSPEIFSDAFIHRVDYVDEKPSAPELQDELRYSSSSASVSEMDMNADERLPREQSHLKIRLLDESDLEKEMENSVSQGLKSPQLECKEEAYVTMSSLFKTQ
Protein: Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) (P70541)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56288}.
Interaction partners:
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2, subunit 2
- Eukaryotic translation initiation factor 2 subunit 3, X-linked
- Eukaryotic translation initiation factor 2 subunit 3, Y-linked
- dTDP-D-glucose 4,6-dehydratase
- Ragulator complex protein LAMTOR3
Sequence:
MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTKDVQKALCAEFKMKLKPDIVCIPDEADMGTADSLRHIYPKLKTDVLVLGCDLITDVALHEVVDLFRAYDASLAMLMRKGQESTEPVPGQKGKKKTVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIHFQTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYLVRKQFSSASSQQRQEDKEEDLKKKEPKSLDIYSFIKKDNTLTLAPYDACWNAFRRDKWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSVLCPEESMIHPSAQIANKHLIGADSLIGSDTQVGEKSSIKRSVIGSSCVIRDRVTVTNCLLMNSVTVEEGSSIHGSVICNNAVVEAGAEIRDCLIGSGQRIEAKAKRMNEVIVGNDQLMEI
Protein: Olfactory receptor 13C9 (Olfactory receptor OR9-13) (Q8NGT0)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MEWENQTILVEFFLKGHSVHPRLELLFFVLIFIMYVVILLGNGTLILISILDPHLHTPMYFFLGNLSFLDICYTTTSIPSTLVSFLSERKTISFSGCAVQMFLGLAMGTTECVLLGMMAFDRYVAICNPLRYPIIMSKNAYVPMAVGSWFAGIVNSAVQTTFVVQLPFCRKNVINHFSCEILAVMKLACADISGNEFLMLVATILFTLMPLLLIVISYSLIISSILKIHSSEGRSKAFSTCSAHLTVVIIFYGTILFMYMKPKSKETLNSDDLDATDKIISMFYGVMTPMMNPLIYSLRNKDVKEAVKHLPNRRFFSK
Protein: Protein ABCI7, chloroplastic (ABC transporter I family member 7) (ABC transporter ABCI.7) (AtABCI7) (Non-intrinsic ABC protein 6) (Plastid SufD-like protein) (Q9LQK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:15184673}.
Interaction partners:
- ABC transporter I family member 6, chloroplastic
- ABC transporter I family member 1
- Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic
- ABC transporter I family member 10
- ABC transporter I family member 17
- Iron-sulfur cluster assembly protein 1
- Protein TRIGALACTOSYLDIACYLGLYCEROL 2, chloroplastic
- Iron-sulfur cluster assembly protein 2
- Iron-sulfur cluster assembly protein 3
- ABC transporter I family member 11, chloroplastic
Sequence:
MAAATVLGRLSLIPNLSSKPKLKSNRRTTSTSVSVRAQASFSDPFVLQLAESLEDSLSASPSSSLPLQRIRDSSAETLLSTPWPSRKDEPFRFTDTSLIRSSQIEPISTQQRNSEILDNLTETQFTNAVIIDGFVSNLTIGPSDLPDGVYFGKYSGLPDELTNRISEFIGNFDSGDLFWSINGMGAPDLMVIYVPEGCKVENPIYLRYFSGETGDRESKRLPVSNPRVFVLVEEGGEIGIVEEFVGKDEEGFYWTNPVLEVVVQKNAKLKHSYLQKESMASAHIKWTFVRQEAESEYELVEVSTGGKLGRHNVHVQQLGPDTLTELTTFHMCVNEQTLDLHSKIILDHPRGASRQLHKCIVAHSSGQAVFDGNVRVNRFAQQTNAGQLTRSLLLKPRATVNIKPNLQIIADDVKCSHGAAISDLEEDQLFYFQARGIDLETARRALISSFGSEVIEKFPNREIRDQARNHVKGLL
Protein: Interleukin-34 (IL-34) (Q8R1R4)
Organism: Mus musculus (Mouse)
Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Macrophage colony-stimulating factor 1 receptor
- Macrophage colony-stimulating factor 1
- Receptor-type tyrosine-protein phosphatase zeta
- Syndecan-1
- CX3C chemokine receptor 1
- Triggering receptor expressed on myeloid cells 2
Sequence:
MPWGLAWLYCLGILLDVALGNENLEIWTLTQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLQKAHVSERELRYLWVLVSLNATESVMDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPGSLMQCTATNVYPLSRQTPTSLPGSPSSSHGSLP
Protein: Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) (Q9Y672)
Organism: Homo sapiens (Human)
Function: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:10359825}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichyl-phosphate beta-glucosyltransferase
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dol-P-Man:Man
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- Alpha-1,2-mannosyltransferase ALG9
- Dol-P-Man:Man
- Phosphomannomutase 2
- Alpha-1,3/1,6-mannosyltransferase ALG2
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Sequence:
MEKWYLMTVVVLIGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILLYPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFSISVRKYLPCFTFLSRIIQYLFLISVITMVLLTLMTVTLDPPQKLPDLFSVLVCFVSCLNFLFFLVYFNIIIMWDSKSGRNQKKIS
Protein: mitogen-activated protein kinase (EC 2.7.11.24) (A0A0G2KB06)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLETSQLPGTHEIEQ
Protein: Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48) (Q9D5E4)
Organism: Mus musculus (Mouse)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9H069}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9H069}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8IVX2}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:31961863}.
Interaction partners:
- Dynein regulatory complex subunit 2
- Dynein regulatory complex subunit 5
- Radial spoke head protein 6 homolog A
- Dynein regulatory complex subunit 4
- Dynein regulatory complex protein 1
- F-box and leucine-rich repeat protein 13
- Radial spoke head protein 4 homolog A
- Outer dynein arm-docking complex subunit 1
- Dynein regulatory complex subunit 7
Sequence:
MSRPYDSMEPKVMDDDMLKAAVGEQGPQEEAGQLAKQEGILFKDVLSLQLDFQNILRIDNLWQFENLKKLQLNNNIIERIEGLTNLIHLVWLDLSFNNIEAIEGLDTLVNLEDLSLSNNRISKVDSLDALVKLQVLSLGNNQISNMMNIIYLRRFPCLRTLSLAGNPVSEAEEYKMFIYAYLSDLVYLDFRRVDEQMREMAKMKHQYSIDELKHREAQLQMKLEEEQAKQEKLEEHKMAFVEHLNGPFLFDSMYSEDVEGNKLSYLPGVRELLEAYKDKFVIICLNIFEYGLNQQEKRKVELDTFNECIQEAILENQDQGKLKVAKFEEKHLLNLNAIREETDLSNIEKKLTECTESIGELFNTLMILEMQLVEQLEETINIFERNITDLVGLFIENVQSLIAQCRDLENHHHEKLLEIAINTLEKILKGEMDEDLPDDVRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTGINSWCAHLVDKIHKDEIMRNRKRVKEINQFVDHMQSELDNLECGDIID
Protein: Ada2a-containing complex component 2 (EC 2.3.1.48) (LD17982p) (Q9VJ73)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- SAGA-associated factor 29kDa
- Ada2a-containing complex component 1
- D12
- histone acetyltransferase
- Transcriptional adaptor 3, isoform C
- Protein Dr1
- Transcriptional adapter 2A
- Ada2a-containing complex component 3, isoform D
- DNA polymerase epsilon subunit 3
- Molybdopterin synthase catalytic subunit
Sequence:
MNRPSNWDDPQGPCRYCESPVEDDNYLECQECRRMVHIKCLPHACTPGDLLGDVFFEFTCVKCVLDKAKESVIPSDLEPIKEVIVRQRIPWLLVLTLTLYNLSIKQKGLGHHGFFHWRTHIISFVDKNWNYIFGPNVRRRKQWTGSVSGALSHNSPEYFQSGLDVFQENGWWKLAKPFQTPRSVLKEYEKKQQLRLQMRIEKRLPAADETSCSSEISVADHAQDNPPLIKAEAEKPSSTEGCARTIPYMGRLPKIQTQPSPLSQETLPGPPILQENIAPPSQKEEEPQNQPMSMVQAGLMDFLAESLESDDFTMFGNLPGIMPPPLIGAGKNDFFMTEPLLHAPLNNEGLFDMDTNFAIPNTADETKPISTEEPAAESSEEQKEGEVEDEKPEEDESPDYQPRIVQVTNYQAQEANESIKEEPLEEIMQDDDVTTNSKSSILEPCKPSGFVRQPRRNWPWLQEAQDPDDMAIPSENLKLINAYEEQKLYQRLDRIFALEHQCHISIPAYVRRLYRKLSLRKWKRDHNRHIFNLDEHIDPLGRARLKMLGHQKAEILDRYQLLAHSRQDARSSFHARLAGCTQYELFESPYSQRVLHPFIFRSETMAPPWLKLMCELQHRVNGSHPTRSTIDFCFVRPQHIPAVNALLQSTFWPNIDVSECLSYPDYSVVALYKKLVIGCGFLVPDVGYNEAYISFMAVRPCWQRSGIASFMLYHLIQTCMSKDITLHVSATNAAVMLYQKFGFKMEEIILDFYDKYLPLDSKQSRNAFFLRLQR
Protein: Uridylate kinase (UK) (EC 2.7.4.14) (ATP:UMP phosphotransferase) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Uridine monophosphate kinase) (UMP kinase) (UMPK) (O59771)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:16823372}. Note=Predominantly cytoplasmic. {ECO:0000255|HAMAP-Rule:MF_03172}.
Interaction partners:
- Uridine kinase
- Nucleoside diphosphate kinase
- Ribonucleoside-diphosphate reductase large chain
- Uracil phosphoribosyltransferase 2
- Orotidine 5'-phosphate decarboxylase
- Ribonucleoside-diphosphate reductase small chain
- Putative uracil phosphoribosyltransferase urg2
- Uracil phosphoribosyltransferase 1
- Golgi apyrase
- Deoxycytidylate deaminase
Sequence:
MYNVIFVLGGPGAGKGTQCDRLAEKFDKFVHISAGDCLREEQNRPGSKYGNLIKEYIKDGKIVPMEITISLLETKMKECHDKGIDKFLIDGFPREMDQCEGFEKSVCPAKFALYFRCGQETMLKRLIHRGKTSGRSDDNIESIKKRFVTYTKASMPVVEYLKSQNRLITIDAEQDPDAVFEDTVKALQPYL
Protein: Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1) (Q6IAN0)
Organism: Homo sapiens (Human)
Function: Putative oxidoreductase.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5RJY4}.
Interaction partners:
- Sarcosine dehydrogenase, mitochondrial
Sequence:
MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRARKERKSKNS
Protein: LIM homeodomain transcription factor (O96686)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MELLKLMMFKSDFLSNGKCDDRVPPINLSQLPEFLLSTIPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDYEEAKAKGLYLDGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSPRTDKFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSYMHGSSSPSQYPPSSRSPPPVGQGHTFGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNNVSDLSNDSSPDQGYPDFPPSPDSWLGDSGSTNTTSANNNANNNSSRSHNNNNSSGGGSGGVSVSTAPNPSAPGVHY
Protein: Intraflagellar transport-associated protein (Protein HEPIS) (Protein NWC) (Q9CQI4)
Organism: Mus musculus (Mouse)
Function: Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.
Interaction partners:
- Intraflagellar transport protein 43 homolog
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
Sequence:
MLAQIPRPEIMDEDQLMKEVLDKFVNCHEQTYEEFLSTFTHLSKEDNVAKWGAHGTDSSENIFSTVKWNHKTESNGRHFRNTSIFLHTSSEHSEEDQIVIDEGHKVGSSFQGDMTRAGKVKVDNFLDLEDVDMEEESKPQMNKDCLLLPGEVEQDISTSVPSYDPSVDLPLTSEVRPKPAVGRTQKQTEEILGDEVQPFFLDEEFDYDNVTLTPKFTAGEIATIQELSKQKRVGSGTNVCELHD
Protein: Flavone 3'-O-methyltransferase OMT1 (EC 2.1.1.42) (P59049)
Organism: Chrysosplenium americanum (American golden saxifrage)
Function: Catalyzes the 3'-O-methylation of the flavonoids luteolin and quercetin. Catalyzes the 3- of 5-O-methylation of the phenylpropanoids caffeate and 5-hydroxyferulate. Substrate preference is 5-hydroxyferulate > luteolin > quercetin > caffeate. Apigenin, kempferol and 3,4-dimethylquercetin do not seem to be substrates for methylation.
Interaction partners:
Sequence:
MLFAMQLASASVLPMVLKSAIELDLLEIIRGQDTCMSPTEIASHLPTTNPDAPAMVDRILRLLSCYSVVTCSVRSVDDQRVYGLAPVCKYLTKNQDGVSIAALCLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMSSFEYHGTDPRFNKVFNRGMSDHSTITMKKVFQAYQGFQGLTSLVDVGGGTGATLTMILSKYPTIRCINFDLPHVIEDAPEYPGIEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKLLKNCYDALPNNGKVILAECILPEVPDSSLATKGVVHIDVITVAHNPGGKERTEKEFEALAKAAGFQGFQVFCNAFNTYIIEFSKQICN
Protein: DNA binding protein MEF2 (Q9PSD8)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRRKIQIIRIMDDRNKQGIFTKRKFGLMKKAYELSVLCDCEIALIIFNGSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLKKKGLDGCESPDDQRYFEEETFSKLIEDSDFVFKRNPPGLPQQPFPMSVAVPVSNPNTLSYSSPGNTMVSASLAASTSLTDASMLSTTPSTLHRNVVSPGIPQQPPSTGNAGNGFVNPRASPSLLGAMGGNVLGKVMPTKSPPPPGGNLVMNSRKPDLRVVIPPSSKGMMPPLNAQRVTSSQATQPLATPVVSVATPSLRPQGLIYSAMPTAYNTDYPLTSADLSVLQGFNSPGMLPLGQVSAWQQHHLGQTTLSSLVATGHLSQGSNLTINTNQHINIKSEPISPPRDRMTPS
Protein: Tyrosine-protein phosphatase-like protein OCA2 (Oxidant-induced cell-cycle arrest protein 2) (P53949)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for normal growth in the presence of linoleic acid hydroperoxide (LoaOOH).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Inositol diphosphatase SIW14
- Putative tyrosine-protein phosphatase OCA1
- Protein OCA4
- Oxidant-induced cell-cycle arrest protein 5
- Putative tyrosine-protein phosphatase OCA6
- GTP-binding protein YPT1
Sequence:
MKYIPPLNFSPVVSTDVSLYRSGYPMPLNYSFIKHQLHLKTIIYIGDKDRPLEEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRNYPILVHSNKGKHRVGVVVGIIRKLLQGWSTAGICQEYGLFSGGMKDGVDLEFITMFETNLKIPRNVIPGFAKHCLYLNELEAAEGSDDESGSESILTAKQPI
Protein: Multi-binding protein (Q0KKW8)
Organism: Bombyx mori (Silk moth)
Interaction partners:
Sequence:
MNNLKFPILFLLTLLPSELIHGQRENKFFRKDYTYIESTESFYKIHTLYKKWVDAKKTCEMEGATFFYPDDKFEFDAVTTYWNTSQPFEWISIGISSQMAKGVFETVDGVSIMDVYNKWKPGEPNDSHNNEDCVVIHRNDGLMNDDDCAKSFPFICKKTLASLEWNVNCDIPNTDYAYSDVLGRCYKMYLTPMTWSEAYRVCSADQSYLAIINTKEEADHLVNMTRLAPKDKVRGKYLAGAVFLGFHNKNKDGWTTIKGGALDNSGYTQWGNGQPDGGDKELCGSMIYNGQLNDISCTQTCLFICEHDVFLHFRRTLR
Protein: Meiosis-expressed gene 1 protein (Protein expressed in male leptotene and zygotene spermatocytes 278) (MLZ-278) (Q61845)
Organism: Mus musculus (Mouse)
Function: Essential for spermiogenesis.
Interaction partners:
- Parkin coregulated gene protein homolog
- Sperm-associated antigen 16 protein
- MORN repeat-containing protein 3
Sequence:
MATSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQVAMVDRWPETGYVKKLQRRDNTFFYYNKERECEDKEVHKVKVYVY
Protein: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (Q8AYC6)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03166}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03166}.
Interaction partners:
Sequence:
MIGQKTLHCFFSTAPPRKRSRSPEPGGDAEVTDDAAKRPKTSDHEAGRASALSPEQLERMRRNKEVALRRLNERSVPPGFGESWRRQLAAEFTKPYFVELMAFVAEERKRYTVYPPPEQVFTWTQMCDIRDVKVVILGQDPYHGPNQAHGLCFSVQKPVPPPPSLENIYKELSTDIEDLTHPGHGDLTGWAKQGVLLLNAVLTVRAHQATSHKEKGWEQFTDVVVSWLNKDLHGVVFMLWGAYAQKKGSSIDRKRHHVLQTVHPSPFSVNSGFFGCRHFSKTNELLKKSGKEPIDWRAL
Protein: Transcription factor SPT8 (P38915)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required, directly or indirectly, for TATA-binding protein function at particular promoters. May promote a functional interaction between SPT3 and TATA-binding protein. Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA complex/transcription factor TFIID complex subunit TAF5
- SAGA complex/transcription factor TFIID complex subunit TAF6
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Histone acetyltransferase GCN5
- SAGA complex subunit NGG1
- SAGA complex subunit SPT20
- SAGA complex subunit SPT7
- SAGA complex subunit SPT3
- SAGA complex subunit SGF11
- Ubiquitin carboxyl-terminal hydrolase 8
Sequence:
MDEVDDILINNQVVDDEEDDEEMLSGLENDSKQDLEGNDDGGEDEEDDDDDDEDDDDDEDEREDDDEQEDDDGEDDAARMDKTATPTNEHQHDEQKAAAAGAGGAGDSGDAVTKIGSEDVKLSDVDGGVGSREASSSTHEASANGEVYEYYKHMLNAAQIADSYNIYPTAAIPIQTHVNALAVSRGLKYLFLGGSDGYIRKYDLLNTLEGKLSLTILQKHSLAESIQNAGILQSYWENEIPQKKSEMKLSANKTDYEPKVSPVHSLEVQSECLFILSGLQNGGITMQGVRYMEGSIAHYFKGRNGHTQIVNILRLNGQEDRFLSGSWDKRLLEWDLQTGDIVNEFKKSRSELSSLEMRPLYSSVDVSGNVNSGKENENADDDMDSLFGDEDEDEKQDAGNEPVETGDGSNGEENKEQISEESLNIVYDESVFMTSGLNGSVHIWDRRMTQSPALSLERGAGVPPWCLSACWGVDGDHVYAGRRNACVEQFDLKMPSKPIHNLKLPSISGPVSCVKAMPNNKHLLCASRDNIRLYNVEIAVDASNSTTKSSKVPFLIVPGHHGGIISNLYLDPTSRFIISTSGNRGWQGNSTDTTLIYDIDLE
Protein: Small delta antigen (S-HDAg) (p24) (P0C6L3)
Organism: Hepatitis delta virus genotype I (isolate D380) (HDV)
Function: Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).
Subcellular location: Virion {ECO:0000269|PubMed:1731113}. Host nucleus {ECO:0000269|PubMed:1731113}.
Interaction partners:
Sequence:
MSRPEGRKNRGGREEVLEQWVSGRKKLEELERDLRKVKKKIKKLEDEHPWLGNIKGILGKKDKDGEGAPPAKRARTDQMEVDSGPRKRPSRGGFTDKERQDHRRRKALENKRKQLSAGGKNLSKEEEEELRRLTEEDERRERRIAGPQVGGVNPLEGGTRGAPGGGFVPSMQGVPESPFTRTGEGLDIRGSQGFP
Protein: Membrane-bound hydrogenase subunit alpha (MBH-alpha) (EC 1.12.7.2) (Q8U0Z6)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Alpha subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane thereby conserving the redox energy in a proton gradient.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10852873, ECO:0000269|PubMed:11054105}.
Interaction partners:
- Mbh13 NADH dehydrogenase subunit
- Membrane-bound hydrogenase subunit beta
- Probable membrane-bound hydrogenase subunit mbhJ
- Mbh14 iron-sulfur protein
- Mbh8 NADH dehydrogenase subunit-integral membrane protein
- Hydrogenase
- Cation:proton antiporter
- Cation:proton antiporter
- Na+/H+ antiporter MnhB subunit-related protein domain-containing protein
- Cation:proton antiporter
Sequence:
MKKVEYWVKIPFGPIHPGLEEPEKFIITLDGERIVNVDVKLGYNLRGVQWIGMRRNYVQIMYLAERMCGICSFSHNHTYVRAVEEMAGIEVPERAEYIRVIVGELERIHSHLLNLGVVGHDIGYDTVLHLTWLARERVMDVLEAVSGNRVNYSMVTIGGVRRDIGEKQKRLILDMIKYYREVLPQIEDVFLHDSTIEARLRDVAVVPKKLAIEMGAVGPTARGSGIKEDSRWSEQLGVYPDLGIKPVTPEDVTGEKARGDVYDRMAVRIGELWMSLDLLEHALDQMPEGKIKTFPKDNILVAKLKLLGDGEGIGRYEAPRGELVHYVRGQKGRDGPVRWKPREPTFPNLFTIAKALEGNELADLVVAIASIDPCLSCTDRVAIVKEGKKVVLTEKDLLKLSIEKTKEINPNVKGDPTPTGIGCSRGV