wanglab/gogpt-training-data huggingface dataset:
Protein: Proline transporter 2 (AtPROT2) (P92962)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Proline transporter that mediates proline and glycine betaine transport. May be involved in the uptake of compatible solutes from the soil into the roots, or in retrieval of apoplastic amino acids delivered to the roots via the phloem. May be involved in delivery of proline to wounding sites. When expressed in a heterologous system (yeast), imports D- and L-proline, glycine betaine and GABA across the plasma membrane. Has the same affinity for D- and L-proline.
Subcellular location: Cell membrane {ECO:0000305|PubMed:15618414}; Multi-pass membrane protein {ECO:0000305|PubMed:15618414}. Note=Plasma membrane.
Interaction partners:
- WAT1-related protein At4g01430
- WAT1-related protein At1g01070
- YTH domain-containing family protein
- Amino-acid permease BAT1
- WAT1-related protein At2g39510
- Delta-1-pyrroline-5-carboxylate synthase B
- YTH domain-containing family protein
- YTH domain-containing family protein
- YTH domain-containing family protein
- Cationic amino acid transporter 6
Sequence:
MDTSEARNRKVVAVEQFDLEVPETAHQISSDSWFQVAFVLTTGINSAYVLGYSGTVMVPLGWIGGVVGLILATAISLYANTLIAKLHEFGGKRHIRYRDLAGFIYGKKMYRVTWGLQYVNLFMINCGFIILAGSALKAVYVLFRDDSLMKLPHFIAIAGVVCAIFAIGIPHLSALGIWLGVSTILSIIYIIVAIVLSAKDGVNKPERDYNIQGSSINKLFTITGAAANLVFAFNTGMLPEIQATVKQPVVKNMMKALYFQFTVGVLPMYAVTFIGYWAYGSSTSTYLLNSVSGPVWVKALANISAFLQSVISLHIFASPTYEYMDTKYGVKGSPLAMKNLLFRTVARGSYIAVSTLLSALLPFLGDFMSLTGAISTFPLTFILANHMYLVAMNDELSLVQKLWHWLNVCFFGLMSLAAAIAAVRLISVDSKNFHVFADV
Protein: Alpha1,4-N-acetylgalactosaminyltransferase (Q6KCK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MFIILVLMVIGGLFYIYTSENKYHSCFMEGQVLATQQALTADGETNLLGDVLQADPKPSPGNSIFFHETSCRLSENRQLETLKVTARQACAIESAAMHNPNFQVFVLFAGPTYRISNNNSHPQPLVEAILSYSNGHLRRLNLESYASGTPMEEWLKDGRLSRSKYLFSHISDFLRYLTLYRYGGLYLDMDVVVLRNMEKVPPNYTGAESNTHLAAGVMNLAATGFGHEIAASCLRDFQHNFNGVDWGNNGPGVITRVAQKICGTKDIALMREDPKRCMGFKVFGRGAFYAVPWKQWRDFFEPEKLEETIARCKDSYVVHVWNKHSSKLPIKIGSKNAYALYAEQNCPRSYKAAGEYF
Protein: Keratin-associated protein 6-1 (Q3LI64)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 6-3
- Keratin-associated protein 6-2
- Keratin-associated protein 22-1
- Keratin-associated protein 26-1
- Keratin-associated protein 20-1
- Keratin-associated protein 20-2
- Keratin-associated protein 8-1
- Keratin-associated protein 24-1
- Keratin-associated protein 15-1
- Keratin-associated protein 7-1
Sequence:
MCGSYYGNYYGTPGYGFCGYGGLGYGYGGLGCGYGSCCGCGFRRLGCGYGYGSRSLCGYGYGCGSGSGYYY
Protein: Peroxisomal membrane protein 2 (22 kDa peroxisomal membrane protein) (Q9NR77)
Organism: Homo sapiens (Human)
Function: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
Subcellular location: Peroxisome membrane; Multi-pass membrane protein.
Interaction partners:
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein PEX16
- Peroxisomal membrane protein 4
- Peroxisomal membrane protein PEX13
- Acyl-CoA-binding domain-containing protein 5
- Aldehyde dehydrogenase family 3 member A2
- Peroxisomal membrane protein PMP34
- Peroxisomal biogenesis factor 3
- ATP-binding cassette sub-family D member 3
Sequence:
MAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFININYVPLKFRVLFANLAALFWYAYLASLGK
Protein: Histone-lysine N-methyltransferase mes-4 (EC 2.1.1.357) (Maternal-effect sterile protein 4) (Q9NH52)
Organism: Caenorhabditis elegans
Function: Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to RNAi. May regulate the expression of genes required for vulval development.
Subcellular location: Nucleus {ECO:0000269|PubMed:16968818}. Chromosome {ECO:0000269|PubMed:16968818}. Note=Specifically associated with the autosomes and with the distal tip of chromosome X. Colocalizes with methylated 'Lys-4' of histone H3.
Interaction partners:
- Polycomb protein mes-6
- Polycomb protein mes-3
- Mortality factor related protein 1
- Retinoblastoma-like protein homolog lin-35
- Chromo domain-containing protein.
- Chromo domain-containing protein
- Protein let-418
- YEATS domain-containing protein
Sequence:
MLPSSGDSSKENCAPQDGIVEKEGPNKPFKKKNVKQRNATPQGAGSETSSNAEDKQEEAPILTNAPKDIISMQIQETKAFLSEYEEFVDTDYPKTTFTHVPRKFLSVSPFTPIEADAEGEFLPDADSKCVICHEEKDKTGKSDLITCHGYINGEMDDGKRLLGNIPMFPCRSKFHASCMINYNSGGFHFQYAARLECQARLLCPLHCCNSCNLDHHKQSAYVGDIAECALCLRAFHLTSCYPSGGRDLNVSITIGGKVEKFEMIICPAHYLPGADVQFYNKHKKRKNAVTVVPKADVTMKSHIKACCVIGCEKSSNSKTIMCKTCCRSFHSGCREVETLNGKPIPDDQCESCVCGDPIPQNTLILAKWTDNSFWLALTLDWYKYPTGNRGNINFERLGYTVVQWLIPQENDKEKQPLMSIVPVSDIARLTKNYFSLAKNSTLRNLWEEKYEEQADTALKRCPYVCKTVFGRLRTSVYYKCEPKLEEYHNNEVCNCEGADRCTKLSCQYLADDYECPPSCSKKGVCHNRQVSMGIVSEKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRRLDSVSISRDFQANHYMMELHKGLTVDAARYGNISRYINHSCDPNAASFVTKVFVKKTKEGSLYDTRSYIRAIRTIDDGDEITFSYNMNNEENLPDCECGAENCMGTMGKAKREKPEVADSSEKAAKKNKSSKKKSVKNQNRKSQEAGKNGTASKKSEISPSKPSTSSASSTSFVQQASWPISQNKKNLKKNSNQPVADTGSTLSTSTELNFHEKPQELLSPVSSRSRAASSSTPRAQKSKSRRDDVESEAPPVKRATPSLQTIQETGKAIEFPATKSAITKARALSTQSVPSPHTVEVKVRAISTRGRVQKETKRFEPI
Protein: tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) (P0A8I5)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Interaction partners:
- tRNA pseudouridine synthase B
- tRNA
- tRNA
- tRNA
- tRNA
- Uncharacterized protein YggL
- tRNA pseudouridine synthase A
- tRNA/tmRNA
- tRNA-uridine aminocarboxypropyltransferase
- tRNA1
Sequence:
MKNDVISPEFDENGRPLRRIRSFVRRQGRLTKGQEHALENYWPVMGVEFSEDMLDFPALFGREAPVTLEIGFGMGASLVAMAKDRPEQDFLGIEVHSPGVGACLASAHEEGLSNLRVMCHDAVEVLHKMIPDNSLRMVQLFFPDPWHKARHNKRRIVQVPFAELVKSKLQLGGVFHMATDWEPYAEHMLEVMSSIDGYKNLSESNDYVPRPASRPVTKFEQRGHRLGHGVWDLMFERVK
Protein: Oligopeptide permease homolog AIII (O31306)
Organism: Borreliella burgdorferi (Lyme disease spirochete) (Borrelia burgdorferi)
Interaction partners:
Sequence:
MSFNKTKKIGKKIKIVTLLMLAVSLIACNNNSEKEKLAFKVYIGGAPSSLDPHLVDETIGARILEQIFSGLLTLNTKTGKLKPGLAKNWEASKDKKTYQFYLRDNLFWSDGVEITAEGIRKSFLRILNKETGSTNVDMLKSIIKNGQEYFDGKVSDSELGIKAIDSKTLEITLTAPKPYFLELLLHYAFMPVPIHVIEKYKGNWTSPENMVTCGPFKLKKRLPNEKIIFEKNERYYNAKEVELDELVYITSDNDLTVYNMYKNNEIDAIFNSIPPDIVNEIKLQKDYYQHKSNAIYLYSFNTKIKPLDDARVREALTLAIDRETLTYKVLNDGTVPTREITPDLKNYNYGKKLALFDPEKSKKLLADAGYPNGKGFPMLTLKYNTNETHKKIAAFIQNQWKKILNINLMLTNENWPVLTNSRNTGNFEIIRVGRIGEYLDPHTYFTIFTRENSQLASYGYSNLEFDKLIRESDLEKDPIKRKQLLRKAESIIIEKDFPAAPIYIYSGHYLFRNDKWTGWNPNVSEVYYLSELKPIKNAKHN
Protein: Sarcomere length short, isoform H (A0A0B4LI42)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLDFLDEWFLSQVPAPPPLPSLVPKAPPPPPPPLAPGEKRVLSSTQKETLEKLRTRPRRRPDWSEMMKEVESGKKLRHVACNDRSQPILTCKSITKLDDKFIYETEKGNSHNKLLKQIQGGIKLKPTKTNDRSKPVLDGLRKFRRQMTIEEQLQKSQSKINMLSEAPSSHALGPGSATALGAGGSRPSIVSAMSIDEESPDELDDIDKIRDDLQSTKQMLALELRNREAQDRENKKLLAKIRTLETELEREKSREKNLEYGSNVIVATMDPTPTAEQTYVNSLKREVEDARKVSKEVEQNYQSTAEQLVEAKTEIEEQRRQIQLLERKLAAALQATPSTNRPHISNCFAYDDDDYDDCFHYDHYHAARHQGGGSLDGSRRPSDANFGRDSSPELEPEVSESDPDEPEEKKVERRERRSGKELKILRSKLTKLKVKEEAAKKEKDALKQAMKKNQSILKEENKKFKKLEKEVQKMAASMKLDEDDVDGEEKDEDEEEAEEEHASEEEEESDDESEESESEESEAETGSESEPEDSPNSAKKANVEPRVKKHESRFAAMKKCNVLLQANVDNLQDQIVQVRSRATNLQDELDAVIADLGF
Protein: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09 (EC 3.6.4.13) (DEAH-box helicase C20H4.09) (Q9HE06)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor cwf14
- Uncharacterized protein C20H4.06c
- Pre-mRNA-processing factor 17
- RNA-binding protein with serine-rich domain 1 homolog
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-splicing factor 18
- Pre-mRNA-splicing factor slu7
- Pre-mRNA-splicing factor cwf3
- Pre-mRNA-splicing factor brr2
Sequence:
MPNEFISQSLSTLTNTPLNIQKKLLPITKYRNQLLYAVEQNQITIVLGHTGCGKTTQIPQFLYEAGWASQNGIIGCTQPRRLVAKSVSERVSLELNSPPGSLCGYSIQFDHNVSEKTKIKYMTDGILLNEIFFDPLLERYSIVILDEVHERTLSTDLLLGVLKRILEKRNDFRLVLSSASVDANKLSQFFGQDKVCTMSIEGKLFPVETLFLQKPTENYVDSAIETVININSTYPPGDILVFLSGRKEIEYCIKKIEDSLIHASEDCQTLVPLPLHAGLTVDEQMRVFNIYDGDFRKVIFSTNIAETSITIDGIVYVVDSGFNKQRIYNPYTRTSKLINVPISKSSAIQRSGRAGRTMRGKVFRLYTEKAYSLMKEEFEADILNCDMSPLVLFLKGLGLKNILQFPFFVRPPTVHLMAALEDLYLLGVLDESGNLTDPLGIQISNSFLDANISKALLTSNQFGCTHEILSIASILTAGEVFYNPTSSSKNDAFVAHSSFFANEGDIITALNVFESFVGNKKDLQWCRKNYLNYQTLRQALDIRTHLVRFLNKFSIPTAQRLPSSDCSKILKCLLDGFVRNVAHLQNDGSYKTIGGKQVWLDSSSVLHEKKTPWIMYSSAVESETQIFVKNISKIESFWLDKYYKREK
Protein: Meckelin isoform X1 (Transmembrane protein 67) (E9QB24)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transmembrane protein 216
- Coiled-coil and C2 domain-containing 2A.
- B9 domain-containing protein 1
- Abelson helper integration site 1.
- Tectonic family member 1
- B9 domain-containing protein 2
- Nephronophthisis 1.
- Centrosomal protein of 290 kDa
- Transmembrane protein 231
- Protein fantom
Sequence:
MATGTRSALLYSVSIIILLKISVFSCQQFSISFRQPSDCGVNSYFDISSLSCVKCGSNQVSSKSGLACECQAGSRVLVSNGVSILCQQCPDADQVVTQDGYECIRCPGTVGKDGKCQCPEGSVLVERDGNGNPLIEARCQACSATDPAFSAPDMKGNRCERCGDSFINSSQSCVCGTSNTLAGGMCFPANSLPTSVASSVIFSQLTLPVQSAWFSSFMYSSAAACLLFSNRTACQSLGNMCVMNMHSSSSINNDVCGLYNTIYRTTAAQGSSQDISYWRTNLPWLYYGDQPGMASQALQNEPLPVGFSFKGAQKNTNIELRAAVYSVRGEFLRWESVGRGNLQLCPDTPTRQQSAFKFGTAYKQSCVLSVSELLTGYPEPLFYDVFLVIQNSQDNRLLAVPLLNANQQFNGQFVNQGSDMSKWFLTRRLMLVDTLSGREKSISSSPVVIRVASDIKIGFQLVPNTQKGQVYPPLMSVAYSDIQIKDPSTQTVTVTFSVEYTMNQEEARIKTDIALGVLGGVAVVHSLLKTASWKRRIASPLIDLETIMKFLVFYAGDLANVFFIITVGTGLYWLIFFKAQLFVSVLLPLPAQEERFVVYVGCAFALKTVQFLHKIFVQLSVDVFFIDWERPRGKTTKHVEGSGETKSQASPVSIWRTYFVANEWNEIQTIRKINPTFQVMAVLFFLEVVGFSNLALRDPSSNLNRSAEEYTPPYSLILRYGVATAMWLCIGLIQMIFFTVFHERFVEDKIRQFVDLCSISNISVLLLSHRCFGYYIHGRSVHGHADTNMDEMNTNLKREAENLCGQRGLLPNSDTQTFQISITNRLRAQYDRIIEPISRRRGPSRLVDATANPCEQSTKAYHTMNRFLGSVIDHAHREMDYIVKDKLLFERVIGMEFIEPLDKSIFYNDDSHSFADVLFYGNEGVLLIFDTLFFCVVDLGKQNFILAAVLTYLQQMIFRLIRNGLGRRNLANKTLVDKRFLI
Protein: Homologous-pairing protein 2 (P53187)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates DMC1-dependent homologous strand assimilation required for the resolution of meiotic double-strand breaks.
Subcellular location: Nucleus {ECO:0000269|PubMed:9708739}.
Interaction partners:
- Meiotic nuclear division protein 1
- Meiotic recombination protein DMC1
- Synaptonemal complex protein ZIP1
- Protein ZIP2
- DNA endonuclease SAE2
- Meiosis-specific protein SPO11
- Meiosis-specific protein HOP1
- DNA repair protein RAD51
- Meiosis-specific serine/threonine-protein kinase MEK1
- MutS protein homolog 4
Sequence:
MAPKKKSNDRAIQAKGSEAEQLIEDYLVSQYKPFSVNDIVQNLHNKVTKTTATKALENLVNEKRIVSKTFGKIIIYSCNEQDTALPSNIDPSQFDFETVLQLRNDLIELERDKSTAKDALDSVTKEPENEDLLTIIENEENELKKIESKLQSLQDDWDPANDEIVKRIMSEDTLLQKEITKRSKICKNLIATIKDSVCPKNMNEFLEEIGFEDI
Protein: At3g60520 (Zinc ion-binding protein) (Q9M207)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVDLERRVCCMCGDVGFFDKLFHCSKCLNRFQHSYCSSYYKEQADPIKICDWCQCEAKSRTGAKHGVNGGSSKRSYRSEYSSPHHQIKQQEINQTTSSSIPPAADKGKTGVPSPRPATRRYKLLKDVMC
Protein: Vascular-related unknown protein 4 (Q5BPG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of plant growth.
Interaction partners:
Sequence:
MESSMNNAFIMSKHETAMFTDDQNPEESSWTMYFEDFFEASSSIVDVGDFSSSSVSDAASFVATKKTLNVSKQEGSNLDIKRTRNREIPFGRHHDLEDTASSPSGSPNVYSMMNLQDNNTRHGGGIVGDDEKRVSAVPNQGGLPIDLKKKGLCLVPLSMVTNFLG
Protein: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (NAD(+) diphosphorylase 2) (NAD(+) pyrophosphorylase 2) (Nicotinamide-nucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (NMNAT 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2) (NaMNAT 2) (P53204)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis (By similarity). Predominantly acts in the salvage pathways via NMN.
Subcellular location: Nucleus {ECO:0000269|PubMed:11884393}.
Interaction partners:
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Glutamine-dependent NAD
- Nicotinate phosphoribosyltransferase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Uridine nucleosidase
- NAD-dependent histone deacetylase SIR2
- Purine nucleoside phosphorylase
- Nicotinamide riboside kinase
- IMP-specific 5'-nucleotidase 1
- Suppressor of disruption of TFIIS
Sequence:
MDPTKAPDFKPPQPNEELQPPPDPTHTIPKSGPIVPYVLADYNSSIDAPFNLDIYKTLSSRKKNANSSNRMDHIPLNTSDFQPLSRDVSSEEESEGQSNGIDATLQDVTMTGNLGVLKSQIADLEEVPHTIVRQARTIEDYEFPVHRLTKKLQDPEKLPLIIVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHFNHEINIKRGGIMTVDGEKMGVKIMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYNLYINQSEPVKQVLDSKE
Protein: Eukaryotic translation initiation factor 4B (F8W0K0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRR
Protein: Origin recognition complex subunit 3 (Q9Y1B4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDPTISVSKGCFVYKNGATRAGKKAASKRKRPAAESSSLLGKEVVQQPFYEEYRKAWNQINDHIADLQHRSYARTLEQLVDFVVGQAERDTPDEVLPTAALLTGINQPDHLSQFTALTQRLHAQRAAMVCVLQSRDCATLKAAVETLVFGLVEDNAEVEQMEDEDEDEDGAERDRKRLRRSQCTMKQLKSWYTNNFDSEQKRRQLVVILPDFECFNASVLQDLILILSAHCGSLPFVLVLGVATAMTAVHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAFHLSGKTFKFLTHIFLYYDFSIHGFIQGFKYCLMEHFFGGNAFALCTDYSKALGRIKQLTHEDMETIRRLPSFRPYVEQINDCKRIIAVLTDDDYLKKKLPQLLRDCLLHFLLFRCSLEFLTELVGDLPRCPLGKLRRELYVNCLNRAIISTPEYKECLQMLSFLSKDEFVAKVNRALERTEQFLVEEIAPLELGEACTAVLRPKLEAIRLAVDEVVKATMATITTTSPNETRQATDHLTPVASRQELKDQLLQRSKEDKMRHQLNTPTTQFGRALQKTLQLIETQIVQDHLRALQDAPPIHELFVFSDIATVRRNIIGAPRAALHTALNNPHFYMQCKCCELQDQSLLVGTLPDLSVVYKLHLECGRMINLFDWLQAFRSVVSGSDNEEVAQEQIDPQIQARFTRAVAELQFLGYIKMSKRKTDHATRLTW
Protein: L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Escapin) (Q6IWZ0)
Organism: Aplysia californica (California sea hare)
Function: Catalyzes the oxidative deamination of positively charged L-amino acids L-Lys and L-Arg and, much less efficiently, of amino acids L-His and L-Tyr. Has antimicrobial activity. Inhibits growth of Gram-negative bacteria E.coli strain MC4100 (MIC=0.62 ug/ml), E.coli strain C921-b2, S.typhimurium strain AA 140 (MIC=0.62 ug/ml), P.aeruginosa strain PAO1 (MIC=0.31 ug/ml) and V.harveyi strain BB170 (MIC=0.25 ug/ml). Inhibits growth of Gram-positive bacteria S.aureus strain 6835 (MIC=0.31 ug/ml), S.pyogenes strain NZ131 (MIC=0.62 ug/ml), B.subtilis strain 168 (MIC=2.50 ug/ml) and B.subtilis strain WB600 (MIC=2.50 ug/ml). The antibacterial effect can be bacteriostatic, mediated mostly by H(2)O(2), as well as bactericidal. The latter appears to be due to unstable intermediates generated from alpha-keto-epsilon-aminocaproic acid, an intermediate of escapin-deaminated L-Lys, and H(2)O(2). The bactericidal effect is stronger at lower pH levels. Intermediates generated from L-Arg have no bactericidal effect. Inhibits growth of yeast species S.cerevisiae strain BY4761 (MIC=5.0 ug/ml) and C.krusei (MIC=5.0 ug/ml). Inhibits growth of C.sphaerospermum in a lysine-dependent manner. As components of ink, products from escapin's enzymatic activity may play a role in deterring eukaryotic predators.
Subcellular location: Secreted {ECO:0000269|PubMed:16354780}.
Interaction partners:
Sequence:
MSSAFLLLACALVISVHADGVCRNRRQCNKEVCGSSYDVAIVGAGPGGANSAYMLRESGLDIAVFEYSDRVGGRLFTYQLPNTPDVNLEIGGMRFIEGAMHRLWKVISELGLTPKVFKEGFGKEGRQRFYLRGQSLTKKQVKSGDVPYDLSPEEKANQGRLVEYYLEKLTGLQLNGGPLKREVALKLTVPDGRFLYDLTFDEALDLVASPEGKEFARDTHVFTSEVTLDASAISIFDDHLGEDYYGSEIYTLEEGMSSVPQGLLQTFLDAAKSNEFFPNNHLKALRRRTNGQYVLYFEPTTSKDGQTTINYLEPLKVVCAQRVILAMPVYALRQLDWSQLRNDRATQAYRAVRPMPASKVFMTFDQPWWLQNERKSWVTKSDALFSQMYDWQKSEASGDYILIASYADGLKAQYLRELKNQGEDIPGSDPGYNQVTVPLKDAILEHLTEAYGVERDSIPEPVTAASQFWTDYPFGCGWITWRAGYHFDDVISTMRRPSLKDEVYVVGSDYSWGLISSWIEGALETSENVINDYFL
Protein: Adapter molecule Crk (Q9XYM0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.
Interaction partners:
- Myoblast city, isoform B
- Guanine nucleotide-releasing factor 2
- Breast cancer anti-estrogen resistance protein 1
- E3 ubiquitin-protein ligase CBL
- Ced-12
- Paxillin, isoform F
- DShc protein
- Tyrosine-protein kinase Abl
- Dreadlocks, isoform B
- Growth factor receptor-bound protein 2
Sequence:
MDTFDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELNGKNGHFPFTHVEFVDDCDLSKNSTEIC
Protein: Nitrate-inducible formate dehydrogenase, gamma subunit (Q9HUZ9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Formate dehydrogenase-O, major subunit
- Formate dehydrogenase iron-sulfur subunit
- Protein FdhE homolog
- S-formylglutathione hydrolase
- Glutathione-independent formaldehyde dehydrogenase
- Formyltetrahydrofolate deformylase
- N-formylglutamate deformylase
- Formyltetrahydrofolate deformylase
- Kynurenine formamidase
- Selenocysteine-specific elongation factor
Sequence:
MKNEIQRYNANERSNHWAVAILFFMAGLSGLALFHPALFWLTNLFGGGPWTRILHPFLGLAMFVFFLGLVVRFAHHNRVQKSDIQWLKQWRDVVSNREENLPEVGRYNAGQKLLFWVLLLSMLTLLVTGIVIWRQYFSAWFGIEAIRLSALLHAFAAFVLIASIIVHIYAGIWVKGSMGAMLYGKVSRAWARKHHNGWLKEVGKGEEH
Protein: ETS homologous factor (E9PQX0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTV
Protein: Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2) (Q91WN3)
Organism: Mus musculus (Mouse)
Function: Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:26739563}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A1
- unspecific monooxygenase
- Solute carrier family 22, member 30)
- Cationic amino acid transporter 3
- Acyl-coenzyme A synthetase ACSM3, mitochondrial
Sequence:
MAMDSKKEIRLKRELGYFWGTNFLIINIIGAGIFVSPKGVLQHSSMNVGVSLCVWAVCAVLTLTSALCSAEIGITFPYSGAHYYFLKRCFGPLVAFLRLWTSLFLGPGLIASQALLLAEYGVQPFYPSCSAPILPRKCLALAMLWIVGILNSRGVKELSWLQTVSSVLKVGILGVISLSGLFLLVRGKKENVQRLQNAFDAEFPEVSQLIEAIFQGYFAFSGGGCFTCIAGELKKPSKTIPRCIFTGLPLVTVVYLLANISYLTVLTPQEMLSSDAVALTWTDRVIPQFTWTVPFAISASLFINLVINVLETSRVLYIASENGQLPLLFCALNVHSSPFIAVLLIISMASILIVLTNLIDLINYLYFVVSIWTALSIIGILKLRYQEPNLHRPYKVFLPFTFIALGITLSLVLIPLVKSPKLHYIYVFLFLLSGLVFYVPLIHFKVKFVWFQKLTCYLQLLFNICIPDVSDDHIHEES
Protein: UBX domain-containing protein (Q54X06)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- UBX domain-containing protein 7 homolog
- NSFL1 cofactor p47 homolog
- UBX domain-containing protein
- Nuclear protein localization protein 4 homolog
- ZZ-type zinc finger-containing protein
Sequence:
MSSIHIIYKTGKTTVPVIASTVMMEVLKKACQYFKIDDSRFQLMYGSTYVNLSLPFRLSGIPNLSRVTIMEKKGASISTVKIAIQMDDGKRFQSNFKTSSTLWDILLTFETEQNLSLTKRFNDVNQYIEPVVTILNREISTIESLQKSSLASINVNEASLIKLTFKQTDRTNEEVLPIIVSYQSPSTPTESPTTTTTTTTTTTTNNTTKEESPKTTNSPTNSESSTKSQNSSGSQQSPIIISPPTQQSTSSDVSTPTMDIDSPLVKNVEKSPISDLGLNPSSNIPLPDKTYNNETTTTTTTTSNNDVQVSTPPKIATMDHKDRELLVYTPSNNQVDPKSIRHNEKMTEEDIKRLVEANKRVKKEKEEFDSVLRTKAMREREAYKKHKNFSTSIIRIVFPGGQKILEMKFLIREKISNLLKYINEYILAQPNDSVYLYTTPPNKTLDLNTTFLKEGLFPRAKIFLGVSPGTTLIFSELVNELIEESNNKNNNNNNNNNTTTTTTSTISQEELDKQEEEQERIEEQMKIEEEKQLKLEDEQEKERQRALRSMFNNEKEGDSQKRPVPKWFTAGKK
Protein: Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) (P00864)
Organism: Escherichia coli (strain K12)
Function: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Interaction partners:
- Phosphoenolpyruvate carboxykinase
- Citrate synthase
- Phosphoenolpyruvate synthase
- Malate dehydrogenase
- Pyruvate kinase I
- Pyruvate kinase II
- Enolase
- Malate synthase A
- Malate:quinone oxidoreductase
- Malate synthase G
Sequence:
MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
Protein: Probable two-component response regulator (Q9HZG3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- Two-component response regulator RocA1
- Oxygen sensor histidine kinase NreB
- histidine kinase
- DUF883 domain-containing protein
- Probable transcriptional regulator
- histidine kinase
Sequence:
MSRILIVDDHPVIRMAMKMLLEAEGHQIVGDTDNGVDAISLGRELKPDLVILDIGIPRLDGLEVISRLMVLALPLKILVLTGQSASLFALRSMQAGAAGFVCKQGGLAELVTAVNAVASGYSYFPSSAMRPVQQGAYSDDVELLGRLSDREVSVLQYLSQGYSNKQISEQMFISNKTVSTYKARLLLKLNAGSLVDLIEFAKRNTLI