wanglab/gogpt-training-data huggingface dataset:
Protein: Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) (Q08290)
Organism: Rattus norvegicus (Rat)
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Interaction partners:
- Myosin-10
- Actin, gamma-enteric smooth muscle
- Actin, aortic smooth muscle
- Smoothelin
- Leiomodin-1
- Actin, alpha skeletal muscle
- Calmodulin-like protein 4
- WD repeat-containing protein 90
- Myocardin
- Transgelin
Sequence:
MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGSNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELDEPTHNHHPHNYYNSA
Protein: Acetylornithine/succinyldiaminopimelate aminotransferase (ACOAT) (DapATase) (Succinyldiaminopimelate transferase) (EC 2.6.1.11) (EC 2.6.1.17) (P18335)
Organism: Escherichia coli (strain K12)
Function: Involved in both the arginine and lysine biosynthetic pathways.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01107, ECO:0000305}.
Interaction partners:
- N-acetyl-gamma-glutamyl-phosphate reductase
- Acetylglutamate kinase
- Amino-acid acetyltransferase
- Argininosuccinate lyase
- Acetylornithine deacetylase
- 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- Succinyl-diaminopimelate desuccinylase
- Argininosuccinate synthase
- Ornithine carbamoyltransferase subunit I
- Ornithine carbamoyltransferase subunit F
Sequence:
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
Protein: Ras-related protein RABA5b (AtRABA5b) (Q9SRS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Trafficking protein particle complex II-specific subunit 120 homolog
- Geranylgeranyl transferase type-2 subunit beta 1
- Kinesin-like protein KIN-14E
- Rab escort protein 1
- Geranylgeranyl transferase type-2 subunit beta 2
Sequence:
MGKEDDRGEEYLFKIVLIGDSAVGKSNLLSRFSRDEFDTNSKATIGVEFQTQLVEIEGKEVKAQIWDTAGQERFRAVTSAYYRGAFGALIVYDITRGDTFESVKRWLQELNTHCDTAVAQMLVGNKCDLEDIRAVSVEEGKALAEEEGLFFMETSALDATNVDKAFEIVIREIFNNVSRKLLNSDAYKAELSVNRVSLVNNQDGSESSWRNPSCCSR
Protein: Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGS) (NAGS) (P22567)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Arginine biosynthesis bifunctional protein ArgJ
- Acetylglutamate kinase
- Argininosuccinate lyase
- N-acetyl-gamma-glutamyl-phosphate reductase
- Argininosuccinate synthase
- Ornithine carbamoyltransferase, anabolic
- Ornithine carbamoyltransferase, catabolic
- Glutamate dehydrogenase
- Succinylornithine transaminase/acetylornithine aminotransferase
- Glutamate-pyruvate aminotransferase AlaA
Sequence:
MPDYVNWLRHASPYINSHRDRTFVVMLPGEGVEHPNFGNIVHDLVLLHSLGARLVLVHGSRPQIEARLAARGLAPRYHRDLRVTDAPTLECVIDAVGSLRIAIEARLSMDMAASPMQGARLRVAGGNLVTARPIGVVEGVDYHHTGEVRRIDRKGIGRLLDERSIVLLSPLGYSPTGEIFNLACEDVAMRAAIDLEAEKLILYGAEQGLLDASGKLVRELRPQQVPAHLQRLGNSYQAELLDAAAQACRAGVKRSHIVSYTEDGALLSELFTRTGNGTLVAQEQFEQLREAGIEDVGGLIELIRPLEEQGILVRRSREVLEREIEQFSIVEREGLIIACAALYPIADSEAGELACLAVNPEYRHGGRGDELLERIEERARGLGLKTLFVLTTRTAHWFRERGFQPSSVERLPAARASLYNFQRNSQVFEKSL
Protein: P2X purinoceptor (P2X purinoceptor 5) (B7ZND5)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000681}.
Interaction partners:
Sequence:
MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLTILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDTDCHAGESVVAGHGLKTGRCLRVGNSTRGTCEIFAWCPVETKSMPTDPLLKDAEGFTIFIKNFIRFPKFNFSKANVLETGNKHFLKTCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIHIEWDCDLDKAASHCNPHYYFNRLDNKHTQSISSGYNFRFARYYRDPHGVEFRDLMKAYGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKEEDNVEVEANEMEQELPEDKPLERVHQDEQALELVQSGRKQNSNCQVLFEPAREKRQAMPARVPDCLLSASVCIPPSRSGLQENAFVNMKPSQILQTVKT
Protein: C2H2-type domain-containing protein (Q4GYJ9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- SET domain-containing protein
Sequence:
MKYCEVQPQTGSRGIKRQRELEENASIPTKGSRATETRGHPVNDPAGTSEPLQCTQCGFVSQSKGGTTPSTKIQYRRGHPLDSNAGTKRSRSITEQEVSLIWNTVTIGLNDTCCTQCRHTHVSKDSLMEHFGGMHRQHPFSVAKESPPPLRSFNVRGFHLHFTFVNRNKTSHSTSGSSIHRHQKHEICVERKHTHSNECEENPTHILVRSSLKCSAVTSGLRAKICRR
Protein: Protein ABC transporter 1, mitochondrial (ABC1At) (AtABC1) (EC 2.7.-.-) (Q9SBB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P27697}; Peripheral membrane protein {ECO:0000250|UniProtKB:P27697}; Matrix side {ECO:0000250|UniProtKB:P27697}.
Interaction partners:
- Ubiquinone biosynthesis protein
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Polyketide cyclase / dehydrase and lipid transport protein
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- NAD
- AT5g10730/MAJ23_90
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Iron-sulfur cluster assembly SufBD family protein ABCI8, chloroplastic
- Magnesium protoporphyrin IX methyltransferase, chloroplastic
Sequence:
MSSWSKSFTRLVNGVSLVAKEIYNQSPELQRARNGDLEGLITSSGKKALVAATDLVGLTSGKLRELSIRRSKEPSVVYFDEGDNKDNVVATPEVRSVNTKPSEKIVDSKVLRNEFSDEVKNSNREGEIKVSGVEAGEIIGVRAVESGTVTEASSPSEVVPPVKRRRPRERKVPSTPMARAYGFFNLGAALAWGAVKESTYRMVNGTPMTPDNQPALSSLMSKENAERLALGLCEMRGAALKVGQMLSIQDESLVPAPILNALEYVRQGADVMPRSQLNPVLDAELGSNWQSKLTSFDYEPLAAASIGQVHRAVTKDGLEVAMKIQYPGVANSIESDIENVRRLLNYTNLIPKGLFLDRAIKVAKEELAQECDYEIEAVSQKRFRDLLSDTPGFYVPLVVDETSSKKILTTELISGIPIDKVALLDQKTRDYVGRKMLELTLKELFVFRFMQTDPNWGNFLYNEATKTINLIDFGAARDYPKKFVDDYLRMVMACAEKDSEGVIEMSRRLGFLTGDESDVMLDAHVQAGFIVGLPFAEPGGYAFRTNNIASSISNLGATMLKHRLSPPPDEAYSLHRKLSGAFLACIKLGATVPCRDLLLQVYNKYQFDDEPQDPVVATSSVSS
Protein: LD24657p (Q9W0X3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Paraplegin, isoform A
- Carboxylic ester hydrolase
Sequence:
MQHTLIRCLGMARISLMRLQPRPTVAASGGQEAGSISKPTQPVSRSFASLPQEQDKKEQNARESLNRLPRLMDFPEIVWPSALNSLKNWITIQFIIRPYFDSEFQLKDFIYGAKQALQVVSSKLMGGDLDSLDNLVSPEAIAELRPVIQKLSMTQRRQLEIKESDIYLSFPYQVGIMFDDANDKLQKRFVEITMVFHVMRGLSEMRERGEEIPWNMGTLPEYQDKVFICNYRFVKEFTAGHQSDWTVNVANQFRAIDLINETI
Protein: Cilia- and flagella-associated protein 20 (Gene trap locus 3 protein) (Q8BTU1)
Organism: Mus musculus (Mouse)
Function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. {ECO:0000269|PubMed:37295417}.
Interaction partners:
- Protein broad-minded
- Cilia- and flagella-associated protein 298
- Oxaloacetate tautomerase Fahd2a, mitochondrial
- ADP-ribosylation factor-like protein 2-binding protein
- Parkin coregulated gene protein homolog
- EF-hand domain-containing protein 1
- EF-hand domain-containing family member C2
- Cilia- and flagella-associated protein 45
Sequence:
MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQNKAKQ
Protein: Netrin-1 (O42203)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MIRILVTCVSMVSITSMVSGARGGYGMSMFAAQSSPPDPCYDENGNPRRCIPDFVNSAFGKDVRVSSTCGSPPSRCCRVTEKGEERSRDCNICDATDPKKTHPPAYLTDLNNPHNLTCWQSENYVQYPQNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIFKSMDYGKTWVPFQFYSTQCKKMYNKPSKAAITKQNEQEAICTDSHTDMQPLTGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVTFNRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHASKCVKDREGNLVCECKHNTAGPECDRCKPFHYDRPWQRATAREANECVACHCNLHARRCRFNMELYKLSGRRSGGVCLNCRHNTAGRHCHYCKEGYYRDMSKAISHRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAAPTSSYSSPDGPTDCDSHCKAPKGKMKVTMKKYCKKDFAVQVHVLKGDKAGEWWKFTINIISVYKQGGHRIRRGDQLLWVRAKDVACKCPKIKPGRKYLLMGSDEEEDSRGQSGVVADRGSLLIPWKDLWARRLRKFQQRDKRGKC
Protein: Protein TAPETUM DETERMINANT 1 (Q6TLJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cell specification during anther and pollen development. Required for the differentiation, specialization and persistence of tapetal cells in the anthers. May serve as an extracellular ligand for the EMS1 receptor kinase to signal cell fate determination during plant sexual reproduction.
Interaction partners:
- Leucine-rich repeat receptor protein kinase EMS1
- Somatic embryogenesis receptor kinase 1
- Transcription factor DYT1
- Short-chain dehydrogenase reductase ATA1
- Protein SPOROCYTELESS
- Transcription factor MYB35
- Somatic embryogenesis receptor kinase 2
- LRR receptor-like serine/threonine-protein kinase RPK2
- Cell division cycle 5-like protein
- Glutaredoxin-C8
Sequence:
MNRRRLLVSATLLSYLLYGMALVSVEASGGEKLRDNLDLTKTTTSSPSISHRKMLLLSPGTGKTERSVEPERIGEKCKSTDIVVNQAVTEPMPNGIPGYMVEITNQCMSGCIISRIHINCGWFSSAKLINPRVFKRIHYDDCLVNNGKPLPFGSTLSFHYANTFPYHLSVAFVTCA
Protein: Protein RESPONSE TO LOW SULFUR 1 (Q9SCK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein SULFUR DEFICIENCY-INDUCED 1
- Beta-glucosidase 28
- Hydrolase-like protein family
- Gamma-glutamylcyclotransferase 2-1
- Probable sulfate transporter 4.2
- 5'-adenylylsulfate reductase 3, chloroplastic
- Sulfate transporter 1.2
- Berberine bridge enzyme-like 18
- Superoxide dismutase 2, chloroplastic
- Serine hydroxymethyltransferase 7
Sequence:
MANRGGCVTVAAEEMDELRRRNIELSREVAEMKTEMIKLWQRTVVAEEAEEQLCSQLAELEVESLEQARDYHDRMLFLMDQISRLSSSSVVSSS
Protein: Neuroserpin (Axonin-2) (Peptidase inhibitor 12) (PI-12) (Serpin I1) (Q90935)
Organism: Gallus gallus (Chicken)
Function: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Subcellular location: Secreted {ECO:0000269|PubMed:8670795, ECO:0000269|PubMed:9442076}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q99574}. Perikaryon {ECO:0000250|UniProtKB:Q99574}.
Interaction partners:
- Programmed cell death protein 10
- Plasminogen activator
- Plasminogen
- Plasminogen
Sequence:
MYFLGLLSLLVLPSKAFKTNFPDETIAELSVNVYNQLRAAREDENILFCPLSIAIAMGMIELGAHGTTLKEIRHSLGFDSLKNGEEFTFLKDLSDMATTEESHYVLNMANSLYVQNGFHVSEKFLQLVKKYFKAEVENIDFSQSAAVATHINKWVENHTNNMIKDFVSSRDFSALTHLVLINAIYFKGNWKSQFRPENTRTFSFTKDDETEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMIVLSRQEVPLVTLEPLVKASLINEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKGLGITEVFSRSADLTAMSDNKELYLAKAFHKAFLEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFFFLVRNRRTGTVLFMGRVMHPEAMNTSGHDFEEL
Protein: ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) (D3ZHR2)
Organism: Rattus norvegicus (Rat)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}. Lysosome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}.
Interaction partners:
- ATP-binding cassette sub-family D member 3
- ATP-binding cassette sub-family D member 2
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PEX13
- Peroxisomal biogenesis factor 3
- Peroxisomal membrane protein PEX16
- Peroxisome assembly protein 12
- Peroxisomal membrane protein 2
- Peroxisomal biogenesis factor 11 beta
- Peroxisomal membrane protein PEX14
Sequence:
MPVLSTPSRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGESTQEASGATTAKAGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDMVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCRFKRTGDLEEAQAGPGSMVHSGVHIEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGISLLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGIPT
Protein: Myosin binding subunit, isoform H (A8JNT4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSLDARNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQISRISDAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQLYSVQRSASLKDNSMYYRKPTVTIATSTAATAINSPSTTVQTPPIRRSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFANAQLDAYKSDNHRLKEENAALIRVISKLSK
Protein: 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) (P06208)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Subcellular location: [Isoform Cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:3275644}.; SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:3275644}.
Interaction partners:
- 2-isopropylmalate synthase 2, mitochondrial
- 3-isopropylmalate dehydratase
- Dihydroxy-acid dehydratase, mitochondrial
- Acetolactate synthase catalytic subunit, mitochondrial
- Branched-chain-amino-acid aminotransferase, cytosolic
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Regulatory protein LEU3
- Acetolactate synthase small subunit, mitochondrial
- Mitochondrial carrier protein LEU5
- Ketol-acid reductoisomerase, mitochondrial
Sequence:
MVKESIIALAEHAASRASRVIPPVKLAYKNMLKDPSSKYKPFNAPKLSNRKWPDNRITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNYNDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATINNIIHSGDVSIPSLAEVEGKNAAASGSA
Protein: Expansin-A7 (AtEXPA7) (Alpha-expansin-7) (At-EXP7) (AtEx7) (Ath-ExpAlpha-1.26) (Q9LN94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity).
Subcellular location: Secreted, cell wall. Membrane; Peripheral membrane protein.
Interaction partners:
- Protein SEED AND ROOT HAIR PROTECTIVE PROTEIN
- Xyloglucan endotransglucosylase/hydrolase protein 14
- Putative pectinesterase/pectinesterase inhibitor 24
- Peroxidase 73
- Pollen Ole e 1 allergen and extensin family protein
- Probable pectinesterase/pectinesterase inhibitor 46
- Peroxidase 7
- Proline-rich protein 3
- Leucine-rich repeat extensin-like protein 1
- At5g05500
Sequence:
MGPISSSWSFNKFFSIVFVVFAISGEFVAGYYRPGPWRYAHATFYGDETGGETMGGACGYGNLFNSGYGLSTAALSTTLFNDGYGCGQCFQITCSKSPHCYSGKSTVVTATNLCPPNWYQDSNAGGWCNPPRTHFDMAKPAFMKLAYWRAGIIPVAYRRVPCQRSGGMRFQFQGNSYWLLIFVMNVGGAGDIKSMAVKGSRTNWISMSHNWGASYQAFSSLYGQSLSFRVTSYTTGETIYAWNVAPANWSGGKTYKSTANFR
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q5LJA5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKDGFSPCCPGWSQTPELKPSACLDLPKWYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK
Protein: Ameloblastin (O55189)
Organism: Mus musculus (Mouse)
Function: Involved in the mineralization and structural organization of enamel.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Amelogenin, X isoform
- Enamelin
- Amelotin
- Tuftelin
- Kallikrein-4
- Matrix metalloproteinase-20
- Pseudokinase FAM20A
- Kallikrein 1-related peptidase-like b4
- Dentin sialophosphoprotein
- Odontogenic ameloblast-associated protein
Sequence:
MSASKIPLFKMKGLILFLSLVKMSLAVPAFPQQPGAQGMAPPGMASLSLETMRQLGSLQGLNALSQYSRLGFGKALNSLWLHGLLPPHNSFPWIGPREHETQQPSLQPHQPGLKPFLQPTAATGVQVTPQKPGPQPPMHPGQLPLQEGELIAPDEPQVAPSENPPTPEVPIMDFADPQFPTVFQIARSISRGPMAHNKASAFYPGMFYMSYGANQLNAPARIGFMSSEEMPGERGSPMAYGTLFPRFGGFRQTLRRLNQNSPKGGDFTVEVDSPVSVTKGPEKGEGPEGSPLQEANPGKRENPALLSQMAPGAHAGLLAFPNDHIPSMARGPAGQRLLGVTPAAADPLITPELAEVYETYGADVTTPLGDGEATMDITMSPDTQQPLLPGNKVHQPQVHNAWRFQEP
Protein: TSC complex subunit 1 (A0A2R8Y6S1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHILTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADTQNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPRKEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS
Protein: Exocyst complex component 3 (Exocyst complex component Sec6) (rSec6) (Q62825)
Organism: Rattus norvegicus (Rat)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12954101}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12954101}. Cell projection, growth cone {ECO:0000269|PubMed:12954101}. Cell projection, neuron projection {ECO:0000269|PubMed:12954101}. Midbody {ECO:0000250|UniProtKB:O60645}. Golgi apparatus {ECO:0000250|UniProtKB:O60645}. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (PubMed:12954101). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (By similarity). {ECO:0000250|UniProtKB:O60645, ECO:0000269|PubMed:12954101}.
Interaction partners:
- Exocyst complex component 7
- Exocyst complex component 2
- Exocyst complex component 8
- Exocyst complex component 6
- Exocyst complex component 4
- Exocyst complex component 5
- Exocyst complex component 1
- Exocyst complex component
- Rab effector MyRIP
- Ras-related protein Rab-11A
Sequence:
MCKDSACFSTMKETDLEAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMCEQYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFAVLDRTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLVIAKNLLVQCFPPHYDIFKNLLSMYHQALSIRMQDLASEDLEANEIVSLLTWVLNTYTSAEMMGNVELAPEVDVNALEPLLSPNVVSELLDTYMSTLTSNIIAWLRKALETDKKDWSKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKEEAQLYKEEHLRNRQHPHCYVQYMVAIINNCQTFKESIISLKRKYLKPETEESLCQSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHLNELMTKKWMLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSAEERKEGAEKMVREAEQLRFLFRKLASGFGEDADGHCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLALRGDASRDMKQTIMETLEQGPMQASPNYVPIFQEIVVPSLNVAKLLK