wanglab/gogpt-training-data huggingface dataset:
Protein: Growth hormone secretagogue receptor type 1 (GH-releasing peptide receptor) (Ghrelin receptor) (B0V1I9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Appetite-regulating hormone isoform X1
- Membrane-bound ghrelin O-acyltransferase mboat4
- Growth hormone secretagogue receptor type 1
- C3/C5 convertase
- Melanocortin 3 receptor
- Agouti-related neuropeptide.
- Protein phosphatase 1 regulatory subunit 35
- Apolipoprotein Ba.
- Guanine nucleotide-binding protein subunit alpha
Sequence:
MPTWTNRSNCSFNCSWDDNATYWGIEQPVNIFPIPVLTGVTVTCVLFFFVGVTGNLMTILVVTKYKDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRIWRYRPWNFGNILCKLFQFVSECCTYSTILNITALSVERYFAICFPLRAKVVVTKGRVRGVILVLWIVSFFSAGPVFVLVGVEHENGTNSWDTNECKATEYAIRSGLLTIMVWVSSIFFFLPVFCLTVLYSLIGRKLWKRKRETIGENASSRDKSNRQTVKMLAVVVFAFVLCWLPFHVGRYLISKSTEMGSPVMSIISHYCNLISFVLFYLSAAINPILYNIMSKKYRMAACKLFGLRNIPRRSTSVAKGESSPCWTESTASL
Protein: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (P97465)
Organism: Mus musculus (Mouse)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Ras GTPase-activating protein 1
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Protein-tyrosine kinase 6
- SH2/SH3 adapter protein Nck1
- Tyrosine-protein kinase CSK
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Tyrosine-protein kinase ABL1
- Adapter molecule crk
Sequence:
MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSRGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGAVAFRLDTAQRSHLLAADAVSSTAWVQTLCRTAFPKGGWALAQTENQPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTSQGNDIFQAVEAAIQQQKAQGKVGQAQDILRTDSHDGETEGKTVPPPVPQDPLGSPPALYAEPLDSLRIPPGPSQDSVYSDPLGSTPAGAGEGVHSKKPLYWDLYGHVQQQLLKTKLTDSKEDPIYDEPEGLAPAPPRGLYDLPQEPRDAWWCQARLKEEGYELPYNPATDDYAVPPPRSPKPAPAPKPQGLILPESGTTRGSGSKGFSSDTALYSQVQKSGTSGAWDCGLSKVGNDRAGVKSEGST
Protein: Neprilysin (Q22763)
Organism: Caenorhabditis elegans
Interaction partners:
- C-type LECtin
- Carboxypeptidase
- C-type LECtin
Sequence:
MSQAIPLVTIAAVVIAVGIAIGSLVLNIIILGNVNTLTTTVNNNPVYHYTPAPQVNSTPGTVNTSPSYTQAANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAALSKIDVTSTTTSKTERITKAAFETCKNNLASPADKTAVVYAEITSLFGGVPFFGEPLKTNVDYWMVAGQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFYVKPQYIAEVNQRVSDVNDLLTAFANAAKKNVGADALLAAAQEVVNFEVQIAMASWPDDLLRNYQQQYNPYNIASATTAYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIAQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVKDQTTLIINNFQGMIDSLNWMDTFSKNRAHNKSDSLVKNFGWPEAMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAVLKKGMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITFPYAAWNPPYYNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENYTPNQIFWITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGRCKVWVGQ
Protein: STE20-like serine/threonine-protein kinase (STE20-like kinase) (mSLK) (EC 2.7.11.1) (Etk4) (STE20-related kinase SMAK) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) (O54988)
Organism: Mus musculus (Mouse)
Function: Mediates apoptosis and actin stress fiber dissolution.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10611247, ECO:0000269|PubMed:9808774}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- G2/mitotic-specific cyclin-B2
- Cyclin-dependent kinase 1
Sequence:
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDEEEEAENALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEQSTSEDKFSNKILNEKPTTDGPEKAVDEHASDVNLETGAELNDQTVGIHENGREKKRPKLENLPDTQDQQTVDVNSVSEENENNRVTLETNTDCLKPEEDRNKENQETLESKLIQSEEINDTHIQTMDLVSQETGEKEADFQAVDNEVGLTKEETQEKLGKDGTAQKVITSDRSSEVGTDEALDDTQKAAELSKAAQSGEGDEALAPTQTLAEKPTEGPEAGGAEEEPPGGERVEDKQPEQQPAVCEAEGQLTSTSETTRATLEQPETDEVEQVSESNSIEELERLVVTGAEARALGSEGEAAATEVDLERKENAQKVPVKAESQAPAASQPSEPHPVLIPSININSETTENKEEMGALPKPETILPPEPEHEKGNDTDSGTGSTVENSSGDLNLSISSFLSKAKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLLQKEEQRAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNVLKNRKKEVMNEVEKAPRELRRELTKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS
Protein: Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb) (Q8NFR3)
Organism: Homo sapiens (Human)
Function: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Serine palmitoyltransferase 3
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase 2
- Serine palmitoyltransferase small subunit A
- ORM1-like protein 3
- Palmitoyltransferase ZDHHC9
- Golgin subfamily A member 7
- ORM1-like protein 1
- ORM1-like protein 2
Sequence:
MDLRRVKEYFSWLYYQYQIISCCAVLEPWERSMFNTILLTIIAMVVYTAYVFIPIHIRLAWEFFSKICGYHSTISN
Protein: Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) (Proteasome subunit beta-4) (beta-4) (Q9R1P3)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P49721}. Nucleus {ECO:0000250|UniProtKB:P49721}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P49721}.
Interaction partners:
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-3
- Proteasome subunit beta type-5
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-9
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-10
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRVIDKDGIHNLENIAFPKRDS
Protein: DNA replication licensing factor mcm4-A (EC 3.6.4.12) (CDC21 homolog-A) (Minichromosome maintenance protein 4-A) (xMCM4-A) (P1-CDC21-A) (p98) (Q5XK83)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:9214646, ECO:0000269|PubMed:9214647}. Chromosome {ECO:0000269|PubMed:9214646, ECO:0000269|PubMed:9214647}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000269|PubMed:9214646, ECO:0000269|PubMed:9214647}.
Interaction partners:
Sequence:
MSSPTSTPSRRKSKRGRGSNPPTPRGEEVQSPPSQKRRTEDSTSIGELLPMPTSPSGDIQSPLFSSPAPSRHSAHQSELDLSSPLTYGTPSSRVEGTPRSGIRGTPARQRADLGSARKVKQVDLHSDQPAAEELVTSEQSLGQKLVIWGTDVNVAICKEKFQRFVQRFIDPLAKEEENVGLDLNEPIYMQRLEEINVVGEPFLNIDCDHLRSFDQDLYRQLVCYPQEVIPTFDMAANEIFFERYPDSILEHQIQVRPYNALKTRNMRSLNPEDIDQLITISGMVIRTSQIIPEMQESFFKCQVCAFTTRVEIDRGRIAEPSVCKHCNTTHSMALIHNRSMFSDKQMIKLQESPEDMPAGQTPHTTILYAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVRNVKSVYKTHIDVIHYRKTDSKRLHGIDEDTEQKMFTEERVAVLKELAAKPDIYERLAAALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDETYDRRLAHHLVALYYQSEEQLKEEHLDMAVLKDYIAYARTYVNPRLGEEASQALIEAYVDMRKIGSGRGMVSAYPRQLESLIRLSEAHAKVRFSSKVETIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKLIQSKGKTPAFKYQQLFEDLRGQSDAAITKDMFDEALHALADEDYLTVTGKTVRLL
Protein: Glutathione S-transferase U16 (AtGSTU16) (EC 2.5.1.18) (GST class-tau member 16) (Q9XIF8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase DHAR2
- Glutathione S-transferase F5
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase F12
- Glutathione S-transferase DHAR3, chloroplastic
- Glutathione synthetase, chloroplastic
Sequence:
MGEKEEVKLLGVWYSPYAIRPKIALRLKSVDYDYVEENLFGSKSELLLKSNPVHKKVPVLLHNNKPIVESLNIVEYIDETWNSSAPSILPSHPYDRALARFWSDFVDNKWFPALRMAAITKSEDAKAKAMEEVEEGLLQLEDAFVSISKGKPFFGGEAIGFMDICFGSFVVLLKAREKFKAEKLLDESKTPSLCKWADRFLSDETVKNVAPEIEKVAEFLQELEVRAQSAASRS
Protein: Perilipin (D0G0B6)
Organism: Sus scrofa (Pig)
Subcellular location: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
Interaction partners:
Sequence:
MASVAVESQPSVVTRVANLPLVSSTYDLVSSAYISTKDQYPYLKSLCEMAEKGVKTITSVAMSGALPIIQKLEPQIAIANTYACKGLDRIEEKLPILNQPTNQVVANAKGAVTGAKDAMTTTVTGAKDCVASTITEVVDKTKEAVTGSVEKTKSVVNGSINTVLGSRMMQLVSSGVEKAFTKSELLVDQYLPLTEEELEKEAKKVEGFDMVQKPSYYVRLGSLSTKLRSRAYQQALTRVKEVKQKSQETISQLHSTVNLIEFARKNVHNANQKIQGTQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLVSNIQGLPQNIHDQANHLGVMAGDIYSVFHNASSFKEMSDGLLSSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQDAQSRGAENTTSPETQQPETKRIKPAPASSAWGSQSGDTSCTVATC
Protein: Glutathione peroxidase (Q7L4Q3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA
Protein: Required for meiotic nuclear division protein 1 homolog (Q8CI78)
Organism: Mus musculus (Mouse)
Function: Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9NWS8}. Note=May be localized in mitochondrial RNA granules. {ECO:0000250|UniProtKB:Q9NWS8}.
Interaction partners:
- Zinc finger and BTB domain containing 2
Sequence:
MPSRLLHTLASLHSISAKAHQCQRLTWLTLRPLRKSESTTCHNGLTIQQHLHSFFPSITADSLNKPEILEMSRITSDTSRLFPLNAVHWLDGKEHWPSMHPFGTHRSMTHKPNLLCSKWFIKAVKRHHSSVSNEALVPKQDLPQIKRPLKASRTRQPSRTNLPDLSVNEDLMQCTAFATADEYHLGSLSQELVSCGYVEVTSLPRDAANILVMGVESSAKEGDPGTIFLFREGAAVFWNVKEKTMKHVMQVLERHETQPYEVALVHWENEELNYIKTEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF
Protein: Muscle-specific protein 300 kDa, isoform F (SD10272p) (Q8T9A8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
METKEKDFKRAKTVRTEYVDGVDEVQRWLLQAEVQVQERSLTPTQMKELLQRINHEITAIYERFTLVKTNGQLIIENCRNSEEKTLVQTTIDQLAASLAQVRGWLDEKKQAVGDSLDAWTRFMNLYQIVMSWASEKRNFIDQTIELRTLPEARNKLNDYVTSVKSIKPIVKHLSEMDKELEHIGQVTTVGDLKDKLQEAEDAKISVEAVLLERNSLLQEACEEWDQCERKIKDIRSWHEKTKQGLDSSQQQKKPLRDQLGFCEKTLADINVQKTKLRLSIEKLEVHFRNGMGGDPRLSENVDDLVRVLDGLGELVKAKSQSLEQTLAQIDVYQQQMQSLRQRIIQEEQQLRLVMAPTYLPHDRERALAEQQACRERVKNLHSKITARNERIKLLIHRGTPDDAKLEI
Protein: Transmembrane protease serine 11F (EC 3.4.21.-) (Airway trypsin-like protease 4) (Q6ZWK6)
Organism: Homo sapiens (Human)
Function: Probable serine protease.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFYYLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTGM
Protein: Calnexin (Q7SYE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Melanosome membrane {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004573}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004583}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004583}.
Interaction partners:
Sequence:
MELKMRLCVALLSLSLCLLLMGPVRAQEEEADDMEMDVEDAIDDMQEEDIEEEEQKAPAPPSAPTVTYKAPEPMGEHYFAEAFDKGTLQGWVLSQAKKDGIDEDIAKYDGKWEVEEMQDSKLPGDKGLVLKSKAKHHAISALLLRPFTFDTKPLIVQYEVNFQTGIDCGGAYVKLLSQTPDLDLEEFVDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGEFEEKHAKKPDSDLRSYYTDKKTHLYTLVLNPDNTFEILIDQTVVNSGSLLNDVTPPVNPPAEIEDPDDHKPEDWDERPKIQDPDAVKPEDWDEDAPAKIADEDAVKPDGWLDDEPEYISDPDAVKPEDWDEDMDGEWEAPQIPNPVCETAPGCGAWERPMIDNPNYKGKWKSPMIDNPNYQGVWKPRKIPNPDFFEDLHPFRMTPFSAVGLELWSMSSDIFFDNFFITSDRNVAERWANDGWGLKKAAEGAAEPGLVNQMITAAEERPWLWIVYVLTVALPLVLIIVFCCTGKKSSASTPAAKYKKTDEPQPDVKEEAEEEEAKDEEPEAKKSEEEDSTGDGDGDDTAENGDKDDNTSNEKSEDDILRRSPRNRKSRKD
Protein: Glutaredoxin-C10 (AtGrxC10) (Protein ROXY 20) (Q29PZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- GDSL esterase/lipase At5g45920
- Zinc finger, C3HC4 type
- Protein RETICULATA-RELATED 4
Sequence:
MKTMRGLRNCSNDAVTLDLTVHPPPPPPLPPPAPSTVSSSTASTSLSFDEEETSESKIGRLISEHPVIIFTRFSSCCMCHVMKKLLSTVGVHPTVIEIDDGEIAYLAVEAAPVLFIGGTCVGGFESLVALHLSGQLIPRLVEVGALWA
Protein: Oxysterol binding protein like 5 (E9PJE6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDP
Protein: Eukaryotic translation initiation factor 5B (Translation initiation factor IF-2) (Q9NJH7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVKAKKGKKEILTKVEGGSSVDEISDVDSDQLSLNNKQNHALKGNQAGDDDVKAVTKGVKKLNVKGKGKAGKNDDSDEEEVVPAKGKASKKSAFELLMDDDEQDEPAAQESQSEEEEKVVVSKPQKNEKKGKKAKRKGKDDDDEDLDKVLAELQAEYAGEAAPAATTVVSPEELADEFSKKKKNKKQAKQAAVAENAGEDEASDDEEGGSTVKSAAQKKKEKKERQKREAALAKQKAATEPKPKPVEKPAPEPEPVATEEVQPAAEEEEEKSSKNKKKGKKDKKAEPEEEKKDAKKKGMSASMVAAMQEQLRKRKEEEERLEREEAERIRLEDEREEARLEAVRLEAERKEKKKQREAERKARLKAEGKLLTKKQKEDRARAQALLESLKAQGLEIPDPNDKRPTRPGTRIRPNKKKGPKEEAAEEEAKAAEAEAQSAAAAAAAAAAEKAEEERVKESWDATDSEAEPEPEEETSQATNNGKTEAAEEENEDTDDDEDDDDDEDDSDDSDGDSDDSREVSVLANDPESRRLRAEARILKRQAEAEKKRSTDELRAGVVCVLGHVDTGKTKILDKLRRTHVQDSEAGGITQQIGATNVPIEAIKEQTKYVKAAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGMGNLLFMIADFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNAYVEYKEVKAAQGVKIAAKDLEKAIAGINLLIAHKPDEVEICTEEVARELKSALSHIKLAQTGVHVQASTLGSLEALLEFLRTSKIPYSAIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEMADSLGVKIFQADIIYHLFDKFTAYREELKQKKREEFRSVAVFPCKLRILPQFVFNSRDPIVMGVMVENGIVKVGTPICVPSKEFVDIGIVTSIESNHKQIEFARKGQEICVKIDPIPGESPKMFGRHFEADDMLISKISRQSIDACKDYFRDDLIKADWALMVELKKLFEIL
Protein: HTH-type transcriptional regulator ExsA (P26993)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Transcriptional regulator that plays an essential role in the activation the type III secretion system (T3SS) operons. In addition, ExsA directly regulates the transcription of ImpA virulence factor that cooperatively inhibits the functions of host macrophages together with the T3SS.
Interaction partners:
- Transcriptional antiactivator ExsD
- Type 3 secretion system pilotin
- Transcriptional anti-antiactivator ExsC
- Type III secretion protein PcrV
- Exoenzyme T
- Type 3 secretion system secretin
- Type III secretion regulatory protein ExsE
- Regulator in type III secretion
- Transcriptional regulator XylS
- Type 3 secretion system needle filament protein
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
Protein: Transforming growth factor beta receptor 3 (Transforming growth factor-beta type III receptor) (Q90998)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- TGF-beta receptor type-1
- Transforming growth factor beta-1 proprotein
- TGF-beta receptor type-2
- Transforming growth factor beta-2 proprotein
Sequence:
MSSSCVTPVFALMILCFADAGPVPRSECVLSPVNSSHPVHALLESFTVLSGCASRGTTGLPQEVHVLNLRNPDEGLDHHEREVTLHLTPISSVHIHQKPLVFLLNSPLPLVWKLKTERLAPGIRRVFFVSSGSIVWFEKGNFSLSAETEEKNFPERNEHLLQWAQKEYGAVTSFTELKISRNIYIKVGEDQVFPPTCNIEKNFLSLNYLAGYLQPKRAEGCLMSNLVQEREVHIIELITPNSNPYSAFQVDIIVDIKPSQPGAKLERNVVLILKCKKSVNWVIKSHDVQGKLEVITSNSIGFGKETERSMTMSKSVIPDIPSSHESLIKWAYEHKYSPVTSYTKAPVANRFHLQLEHTEEMNDEEDHSLPPELTELLHGAKNPALSDGLTFPFHINRGGHETGGEGIFPSRDSVDTLINHDFEHSLSKHKEPEEVQGSADVALSIKCDDKVMTVAVEKDSLQASGYTRTELSLLDHSCKARMNGTHFILESLPNKCGTRTSYILDKIVYFNSIVIQLSSPAEGSSFDDDDMESGDNGFPGDADEGDVTFSNWPEIAFNCTLHQPEKDFFNPAMFWPPEPHITNVTFNMELYKTDLFLAPSQGLFSVAENGPIYVEVSVTKADISLGFAIQTCFVSPFSNPDRMSDYTIIENICPKDESVKFYSTEKLNFPIAHAQKDKKRFSFVFKPIFNISLLFLHCELTLCTNIDKDTQRLPKCVPPDEACTSLNVDMILAMMHNKKTFTKPLVITHEGKPEDSSLPKSNVRQPSVFYGLDTLTVVGIAFAAFVIGALLTGALWFIYSHTGEAAGRRQVPTSPPASENSSAAHSIGSTQSTPCSSSSAT
Protein: 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Q38DE4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyltransferase, putative
Sequence:
MVTWALKYFVRVVRWSTEAFLIWPTRPLFDYATSLHCVPISGTFITSVLLCFYGFPLFWSTAMVAVGFIISGVLFLVSPLPLLKPIGGRYSVGLVHMNGCRSQSIPPVAVFYPTNMVPEKKGLPYVPFGDDRFLRGVAAYANVPFFFIRDFSFVRISASRNAVPAALLNQYERVPPIVVFSHGLAGYHLFYSCFALDLAARGAIVICLGHCDNSASFMRDSSGKESEVPLKDYGWEVPAREAQVAQRVSEVRGTLQRLTEKDFWTTLGYINSDIDKFLSKPLQVHLAGHSFGGATVLAAALEENQNPVKGVSVKSVYTFDPWMVPIQNEHFCNPLSDGRKSYTVPTVTVHSDDWVKDSESWEFFKRMKALVLEQSAYASLNEVEKQALFGIVVTKNTNHLSLVDVSVLSPVMHGNIWATVSPRVQIMEWCNALLRFAKQNTEVCSTC
Protein: Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (P25977)
Organism: Rattus norvegicus (Rat)
Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P25976}.
Interaction partners:
- DNA polymerase iota
- RNA polymerase I subunit E
- Rrn3 protein
- TATA box binding protein
- DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerase I subunit RPA1
- NAD-dependent protein deacetylase sirtuin-7
- TATA box-binding protein-associated factor RNA polymerase I subunit A
- Mitogen-activated protein kinase 3
- Stromelysin-1
Sequence:
MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRGPNPKSSRTTLQSKSESEEDDDEEDDDDDDEEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEDDDDDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDSDSN
Protein: Neuronal calcium sensor 1 (Q804C0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphatidylinositol 4-kinase beta
- ADP-ribosylation factor
- ADP-ribosylation factor
Sequence:
MGKSNSKLKPEVVEDLCRKTYFTEKEVQQWYKGFIKDCPSGQLDSSGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRDEMLNIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGMLTLQEFQEGSKADPSIVQALSLYDGLV
Protein: MYG1 exonuclease (EC 3.1.-.-) (Q9HB07)
Organism: Homo sapiens (Human)
Function: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:20377893}. Mitochondrion matrix {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:20377893}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JK81}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
Sequence:
MGHRFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQVDPSGEIVELAKGACPWKEHLYHLESGLSPPVAIFFVIYTDQAGQWRIQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHRTREGALSMARATLAQRSYLPQIS