wanglab/gogpt-training-data huggingface dataset:
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (Q55GU8)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2
- Major vault protein beta
- Major vault protein alpha
- poly
Sequence:
MEKHQNQVIEENRSKPLINLTFFIDSKSKFKVSNYTLSKLIKDEFGGSIAFTLNPKVDYVITTSANFFSTKTTTFLSNQDLSKIKLINEDYFISQQKLEPTQRSKINDSYSIGNKQDSQVVNVCKKENDVVEKADDDLLKIIINPKHIPSVCYGANELKQPYFPEEYLILKSNLLSSTIIGKQNTNKFFYLELHQAIDNNLKKFYRIFTQFGRTDEIQKSNSQHRYVSNDLKEAMALYSSIYSQKIESDNGYIEVKMNSITKIGSKLKLAQLKQQKENDVNANTHIKVYNEETGEEETGQQSLFQRSYIETNVSKLMDIIYKEASKCLIKNFSVEVTENGIETQLGALSMAQIEEAKSILNEINNVLNKDGIDNQENLEMLSSRFYQLVPSKISTKKNRDSSKSVINSFESLNQLSELMNMMKDLTNSFNSNKTTSESKNHLDMKYYALNTHIEHLHQASAGYQIFIRNFLSNPHHQKAIDNGEIKILNCYRLDKKLESDNFLDVGNVQYLYHGSKPQNLVGLLSRGILPPDYVKQIGGKRTDFGYLGSGIYFSDDVVSSTYTSPIGEKGSRFIIMSSVSLGKVKEFSKIQPSLQCAPSGHHSCKGLKSTPTNPTDFKNNEYVVFNPNQSKLSFLIEYIENYKK
Protein: Uncharacterized protein (Q389F7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYTTTAKQPTVVGERAFSMSEKVLTFPSAVTSMTVTPDHVWLVMSDGGVQIRDVSTTELVHCFASASRPRRVVRIWSILAVPDPAVGLQVWMGLSNGAVEVYDAQTFGVLRQQTKHAGGVYCLAEFGGYVYSGSSDFKIGQWYAADARLVRMLHGHSNYVRCLYAEGNAVVSGSDDCTVRVWDVGSGDAQLTGRFHDRSAVSALCRVGITMWSGDDSGRVAVWRLDTCEALHILQAHSGRVSSLKKVGSRVYSGGADGVIAVFDAEEGRLLSHVNNYHGVRVSSLVVTSELRRFCIWSSSADKMIQCWHQDEYTVMIGDQERFSERFWYETGSTPYREFRDSVLKHIGNLRETLKIRTSDNPRLVDIVGLSNSASTVEGFRKREAILNKELSSLEGRQASLESQLEQSKGVLENIEKETSLVLGILRAAQAELRSLDPVLHGSLLMSAGGDANGPLANIVSTLSGQPATMTNVPNPPGNLAVPTSTAATTSAWPAIPSAAAVGSGAQYAAYQPTAIQGHPFYVGTPATYTQPASVSHPVAGVSGATVSNLQSPVPPVQVCGTTPTGVSTAQIPGGQGVAFTALQPAGTMAVGGPTGSTNAVQQVPTAATTPSGTTAAAMVGALPPGQSTATTSAQPLGTAAAGAMAGALPPGQSIATTSAQPLGTAAAGAMAGALPPGQSIATTSAQPLGTAAAGAMAGALPPGQSIATTSAQPLGTAAAGTMAGALPPGQSIATTSAQPLGTAAAGTMAGALPPGQSIATTSAQPLGTAAAGAMAGALPPGQSIATTSAQPPSTLGVGGSTGAPTFGQNFAVSLQPSTATTSVGPAGLTSSAANMAVSSQPLGASTVVDASGPLHSGQSLTGSAHPLSTQASGKLMGTASAGESVTTPFQPLGATANGSSLVFTTAGQSLTAIPQSLGVASTGQSTAQIPGGQGVAFTALQPAGTMAVGGPTGSTNAVQQVPTAATTPSGTTAAAMAGALPPGQSIATTSAQPLGTAAAGGPAGKPPVEQDFLSTKRVVPPVSRCGTAPPSKHVHFEQVAEATTSGGVVYRGVEWTNKNVGNYIQRRYYGAEPSLRTPALEKRRRLQGRMPDVKLEPFKRKDEG
Protein: Cytochrome P450 monooxygenase helB4 (EC 1.-.-.-) (Helvolic acid biosynthesis cluster protein B4) (Q4WR22)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton. This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid. Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order. The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21. C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation. The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC.
Interaction partners:
- Acyltransferase helD2
- 3-ketosteroid 1-dehydrogenase helE
Sequence:
MVEILRFIPLVLLLTLTWRITYELFFSPLRHIPGSLLARLSSKYSILKRVLSDGPQSVQADYQYYGNIYVHRPNGVSISHPDDIRTVLLSPEFRKTKVYEMLDIEGHASIFTTRDPAQASRRRRQIGPYLNHGYLGRMEGLIMKYSVLAIKRKWDRLLEESGGQQVTVNYRDHKQYATFDTIGALAFGREFNALTNDDRTVIRWIEATGLYLGIRKNFPLLKLWPFSRVLRQYRERYERFIAYSKESVTRRKNLLSTVGERPMDLLQAFIDAEDPENPHVKMTADEVMTESIAMQLAGSESTSFVTSWVIHLLTLYPQHLAKVTEEIRSQFSPSHLITFAECRDKLPYLEACVYETLRYSPITSGFLPRISYTKGLTIQGHYIPPGVEIAINLHGAHINKDVWTNPHLYDPTRFLGDDQAKRNVFAFSYGHRNCIGRNLAMMEIMIIIANILKEYDIALPEDSVHGPWNVDALGRPRIMPTRSALFTTPKYPERDCRLVVSRRQ
Protein: Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) (P16383)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised introns.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:24304693}. Nucleus, nucleolus {ECO:0000269|PubMed:24304693}.
Interaction partners:
- Tuftelin-interacting protein 11
- ATP-dependent RNA helicase DHX15
- Pre-mRNA-splicing factor SYF2
- Peptidyl-prolyl cis-trans isomerase-like 1
- Leucine-rich repeat flightless-interacting protein 1
- Pre-mRNA-processing factor 17
- RNA-binding protein 8A
- Pre-mRNA-processing-splicing factor 8
- CWF19-like protein 2
- Probable ATP-dependent RNA helicase DDX23
Sequence:
MAHRPKRTFRQRAADSSDSDGAEESPAEPGAPRELPVPGSAEEEPPSGGGRAQVAGLPHRVRGPRGRGRVWASSRRATKAAPRADEGSESRTLDVSTDEEDKIHHSSESKDDQGLSSDSSSSLGEKELSSTVKIPDAAFIQAARRKRELARAQDDYISLDVQHTSSISGMKRESEDDPESEPDDHEKRIPFTLRPQTLRQRMAEESISRNEETSEESQEDEKQDTWEQQQMRKAVKIIEERDIDLSCGNGSSKVKKFDTSISFPPVNLEIIKKQLNTRLTLLQETHRSHLREYEKYVQDVKSSKSTIQNLESSSNQALNCKFYKSMKIYVENLIDCLNEKIINIQEIESSMHALLLKQAMTFMKRRQDELKHESTYLQQLSRKDETSTSGNFSVDEKTQWILEEIESRRTKRRQARVLSGNCNHQEGTSSDDELPSAEMIDFQKSQGDILQKQKKVFEEVQDDFCNIQNILLKFQQWREKFPDSYYEAFISLCIPKLLNPLIRVQLIDWNPLKLESTGLKEMPWFKSVEEFMDSSVEDSKKESSSDKKVLSAIINKTIIPRLTDFVEFLWDPLSTSQTTSLITHCRVILEEHSTCENEVSKSRQDLLKSIVSRMKKAVEDDVFIPLYPKSAVENKTSPHSKFQERQFWSGLKLFRNILLWNGLLTDDTLQELGLGKLLNRYLIIALLNATPGPDVVKKCNQVAACLPEKWFENSAMRTSIPQLENFIQFLLQSAHKLSRSEFRDEVEEIILILVKIKALNQAESFIGEHHLDHLKSLIKED
Protein: Crk-like protein (V-crk avian sarcoma virus CT10 oncogene homolog-like) (V-crk sarcoma virus CT10 oncogene homolog (Avian)-like) (Q6PH06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- CRK SH3-binding GNRP
- Rap guanine nucleotide exchange factor
- Breast cancer anti-estrogen resistance protein 1
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Paxillin
- Paxillin
- Epidermal growth factor receptor precursor.
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
Sequence:
MSSARFDSSDRASWYFGPVSRQEAQNRLQGQRHGMFLVRDSSTCPGDYVLSVSENSKVSHYIINSLPSKRFKIGDQEFDNLPGLLEFYKIHYLDTTTLIEPAPRYPSTALPSGPIQPSGGLGDENQEYVRTLYDFTGSDAEDLPFKKGEILIIMDKPEEQWWSAKNKEGRTGMIPVPYVEKLVRSSPHPGQSIHGSRNSNSYGIPEPSHAYAQPQTPSPIPPGTPGAVINPLPSVQNGPVLAKAIQKRVPCAYDKTALALEVGDIVKVTRMNISGQWEGEVNNRRGLFPFTHVKILDPQNPDESE
Protein: 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) (Q381D8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small ribosomal subunit protein mS29
- 30S Ribosomal protein S17, putative
- 40S ribosomal protein S5, putative
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL29m
- 50S ribosomal protein L13, putative
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Large ribosomal subunit protein uL3m
- 50S ribosomal protein L2, putative
Sequence:
MRCTLPLCSKGLFWRDFPNTRLVTLNREKALNALNLEMVREMSLAYFHEHHPKGDNALFVVKGMGEKSFCAGGDIVMITTDNSVVNEFFYREYQLNHRILTMPNPQVSLWNGYVMGGGVGISVHGRYRVASERAIFAMPENGIGLFPDVGASWFLPRLKLPGFGLYLGLTGGRVKGADLVHLGLATHYVPAASFEQLEDRLCHIEDSTKVDACLNEFAVKDLPPFTLEEHRPLIEKVFTLKDTSTVEDVMGSLAADGGEFARTAISTMEKLSPTSLKLALKMQQMGAKATDPAEVFSTDYVGAIRTHACGDFPEGVRALLIDKTKDPKWNPGKLSDVTPEHLAKFFEPLGPDMRKWHPTEPY
Protein: Prosaposin (F1SU97)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
ALASPVLGLRECTRGSAVWCQNVKTASDCGALQHCLQTVWNKPTVKSLPCDICKDVITAAGDMLKDNATEQEILVYLERTCDWLPKPNMSATCKEIVDSYFPVILDMIKGQMSKPGEVCSALNLCESLQKHLAELTQQKQLESNQIPELDLAEAVAPFMANIPLLLYPQDGSSSKPRPKADGDVCQDCIQMVTDLQNAVRTNSTFVEALVNHAKEECDRLGPGMADMQPKDICGLVGFCEEVKEVPMQTLVPAKVLSEKVISALELVEPIKKDLVPEKATIYCEVCEFVVKEVAKLIDNNRTEEEIIHALDKVCSKLPTSMSEECQELVDTYGSSILSLLLQEASPELVCSMLHLCSTQGLPVLTARVTPLKDGGFCEVCKRLVSYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVTEYEPVLVEILVEVMEPSFVCSKIGACPSAHKPLLGTEKCVWGPSFWCQNMESAALCNAVEHCKRHVWN
Protein: Fasciclin-like arabinogalactan protein 1 (Q9FM65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be a cell surface adhesion protein.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:15593128}. Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Fasciclin-like arabinogalactan protein 15
- Fasciclin-like arabinogalactan protein 16
- Fasciclin-like arabinogalactan protein 21
- Fasciclin-like arabinogalactan protein 18
- Putative fasciclin-like arabinogalactan protein 20
- Fasciclin-like arabinogalactan protein 19
- At1g65720/F1E22_13
- Arabinogalactan protein 13
- CHCH domain protein
- Classical arabinogalactan protein 9
Sequence:
MAKKMSSLIIIFNILLLLTTQTHAHNVTRLLANHPSFSSFSHFLTQTHLADEINRRRTITVCAVDNAAMSALTSKGYTLSTLKNILSLHVLLDYFGTKKLHQIRDGSALAATLFQATGAAPGTSGFVNITDLRGGKVGFGPDGGDLSSFFVKSIEEVPYNISIIQISRVLPSETAAAPTPAPAEMNLTGIMSAHGCKVFAETLLTNPGASKTYQESLEGGMTVFCPGDDAMKGFLPKYKNLTAPKKEAFLDFLAVPTYYSMAMLKSNNGPMNTLATDGANKFELTVQNDGEKVTLKTRINTVKIVDTLIDEQPLAIYATDKVLLPKELFKASAVEAPAPAPAPEDGDVADSPKAAKGKAKGKKKKAAPSPDNDPFGDSDSPAEGPDGEADDATADDAGAVRIIGGAKAGLVVSLLCLFASSWLL
Protein: Stomatin (A0A8I5ZV26)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
CVRRRQGNSGKASCVALFLTDNSKAELGPCGWILVAVSFIFVLITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIMGSHH
Protein: CDC25-like phosphatase YCH1 (EC 3.1.3.-) (CDC25 homolog 1) (P42937)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein phosphatase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Thiosulfate sulfurtransferase RDL2, mitochondrial
- Thiosulfate:glutathione sulfurtransferase
- GTP-binding protein GTR2
Sequence:
MDSYSITNVKYLDPTELHRWMQEGHTTTLREPFQVVDVRGSDYMGGHIKDGWHYAYSRLKQDPEYLRELKHRLLEKQADGRGALNVIFHCMLSQQRGPSAAMLLLRSLDTAELSRCRLWVLRGGFSRWQSVYGDDESVTAGYLPDLWR
Protein: Candida glabrata strain CBS138 chromosome A complete sequence (Q6FY39)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome D complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- Golgi SNAP receptor complex member 1
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome F complete sequence
- Lysophospholipase 1
- Candida glabrata strain CBS138 chromosome F complete sequence
Sequence:
MKFGGFSTLTQAAAALALFNAVDAFDASSPGRTDLNTTEIDTGAFLGDLDVVKVPESANLSEYILTYAGSDKALLDEKTGYVLLNITQNYAGNDTMAKRDVKVYGYDGWYQTWHQMQTVNKGEWWSPWYPISQCVSNGLNDAEASISVNFAYTYTWSLEWGLNAGPDVVGASIGYSISDSVGWGGQFQCNIAPHTRGQIWYQQRVAWADIQKQDCRRENNGKVTCSPWSAFNRVNAPLKGADNVHLGCSSGEDNIQCDAHFDSRLGQIFRNI
Protein: Major outer membrane protein OMP-1M (Q2GF80)
Organism: Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Interaction partners:
Sequence:
MILINMKLFYHLDNIMTKFSAIGIVLSLVTLFACNVFASPIPIDFSNESETAGFYASGHYNIQFPRFSPISVKYKTDENTEKELTLFTLKESTDTPTFKQKSEFNDKKGYSPIYNRNYTGFSGAIGYSGGGLRVELEGAFTRFDVDKQKYKKDNYRYFALCKKDSIESTDNSNGNHVVMKNEGFRVISLTFNACYDMIVSNSSLVPSACIGIGQGITNFLGGTNIHTLFKAKLGLGFLISPKTVIFANGYYVKTKDNSFTNLSVQYPLELKEAPKHIDPIACFNADNYGGEVGLRFIL
Protein: G-protein coupled receptors family 1 profile domain-containing protein (G-protein-linked acetylcholine receptor GAR-2a) (Q8MQ41)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAVASVLLALFMLFLSIVTVIGNLAVLLSYYLDKNIRQPTNYFIFSLAISDLLIGLEGIPVYTAFYLNNNEWIWGDVLCDLWLSIDYIVCLASIYTVLGITVDRYYSVKKPATYRNWRTPGRVVLIIIFIWLVPSILFSVSIFGYGTFTGTGRILKETECYVQFMTNPYLNMGMYISYYWTTLFVMLYLYWGIYRAAKKLALKSDQKTKRLALLTEMRRPEVSVRTSDAGNSSSDSPNDTSNSSKCFRTAPPTTTVQTTQTNVGTPPPVFRNHMTLHNNNMDFTKDNEIVRPPTPPDDNTYSNPNFSMISEQLTNGFSRQEPSSVIERESTAPCVSPEPSHASLENEFNENHHAHFKPELSLPFIDADSVSSMVGHDDLRRAMSIRISRSVSMQGTARATPVIEIVENLEEALKICENLEELREDENKNEEEKQKNGLENGGMNHVIIANDEQQPSTSKESEQKEEMTPENHDPNEVKVPLIAVSRVESVKSTAGGKVRRLITQMRSHSIRSKRKANKNKVSTCSPKSTTSLLLPPSTSSTTRERTRHPVTITLQFQSVLSALNFFQRKKEYKSRSENRARKALRTITFILGSFIILWTPFYVLATIYGFCETCKASPSFNTLYTISYYLCYMNSPLNPFCYAMANQQFKKTLTRIFKGDFRRV
Protein: Glycerol-3-phosphate regulon repressor (P0ACL0)
Organism: Escherichia coli (strain K12)
Function: Repressor of the glycerol-3-phosphate regulon.
Interaction partners:
Sequence:
MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSVMQVLTDHHIQLELC
Protein: Small ribosomal subunit protein eS6z (40S ribosomal protein S6-1) (O48549)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
Interaction partners:
- Small ribosomal subunit protein eS24z
- Large ribosomal subunit protein uL18z
- Small ribosomal subunit protein eS21z
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS12z
- Small ribosomal subunit protein uS15z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS24y
Sequence:
MKFNVANPTTGCQKKLEIDDDQKLRAFYDKRISQEVSGDALGEEFKGYVFKIKGGCDKQGFPMKQGVLTPGRVRLLLHRGTPCFRGHGRRTGERRRKSVRGCIVSPDLSVLNLVIVKKGENDLPGLTDTEKPRMRGPKRASKIRKLFNLKKEDDVRTYVNTYRRKFTNKKGKEVSKAPKIQRLVTPLTLQRKRARIADKKKKIAKANSDAADYQKLLASRLKEQRDRRSESLAKKRSRLSSAAAKPSVTA
Protein: Kazal-like domain-containing protein (G1MZX1)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLYIPAVTSALPLPLREQAGCVGTSRSAMRTAKQFVQVALALCCFADITFGIEVDCSLYASGIGKDGTSWVACPRNLKPVCGTDGSTYSNECGICLYNREHSANVEKEYDGECRPKHITIDCTRYRQVVRDGNVMVACPRILKPVCGSDSFTYDNECGICAYNAEHHTNVSKLHDGECKLEIGSGWPGIRIHALPSCLQVDCTKYPSTVSKDGRTLVACPRILSPVCGTDGFTYDNECGICAHNAEQRTHVSKKHNGKCRQEIPDIDCDQYPTRRINGGKLLVRCPRILLPVCGTDGFTYDNECGICAHNVQHGTEVKKSHDGRCKEHSTPLDCTQYLGNSRNGEAVAACPFILQEVCGTDGVTYSNDCALCAHNIELGTSVAKKHDGRCTEEVPEVNINPGSRDAVHFLHAVRERKRRGQLDCSKYRTSTLKDGRQLMACTMIYDPVCATNGVTYASECTLCAHNLEHRTNLGKRKNGRCEEDITKEHCQGIQQVSPICTMEYIPHCGSDGKTYSNRCVFCNAYLESNRTLNLVSMTEC
Protein: Zinc finger protein basonuclin-1 (O35914)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator. It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (By similarity). Required for the maintenance of spermatogenesis. It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (By similarity). May also play a role in the early development of embryos.
Subcellular location: Nucleus {ECO:0000269|PubMed:23707421, ECO:0000269|PubMed:9687312}. Cytoplasm {ECO:0000269|PubMed:23707421, ECO:0000269|PubMed:9687312}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23707421}. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. {ECO:0000269|PubMed:9687312}.
Interaction partners:
Sequence:
MAEAIGCTLNCSCQCFKPGKINHRQCEQCRHGWVAHALSKLRIPPVYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSVIVPPTTANVDIRAFIESCGHRSASLPTPVDKGSPGGMHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGQDQSQEPKQELHGPFSDSSFLTSTPFQVEKEQCLNCPETVPQKEDSAHLSDSSSYSIASKLERTQLSPEAKVKPERNSLSAKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSETYKRPGFTVVSPDCGPLPGYTGSVEDSKGQPAFSSIGQNGVLFPNLKTVQPVLPFYRSPATPAELANTPGMLPSLPLLSSSIPEQLVSTDMPFDALPKKKSRKSSMPIKIEKEAVEIAEEKRHSLSSDDEVPLQVVSEDEPEDSSPRSDRVPEEQHTQLSLEEPLPQGERACHLESVIESHGALSRTLEQTTLTEREAEQKVALSSVMPREVEDGGHERHFTAGLVPQIPFPDYMELQQRLLAGGLFGALSNRGMAFPFLEESKELEHLGEHALVRQKEEARFQCDICKKTFKNACSMKTHEKNTHARETHACTVEGCGAAFPSRRSRDRHSSNLSLHQKVLNEEALETSEDHFRAAYLLQDVAKEAYQDVAFTPQASQTSVIFKGTSGMGSLVYPISQVHSASLESYNSGPPSEGTILDLSTTSSMKSESSSHSSWDSDGVSEEGTALMEDSDGNCEGQSLVSGEDEYPLCVLMEKADQSLASLPSGLPITCHLCQKIYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHKSLASSPSHLQ
Protein: At5g02050 (Mitochondrial glycoprotein family protein) (Q9LZM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Single-stranded DNA-binding protein
- Putative DNA-binding protein At1g48610
- Eukaryotic translation initiation factor 4C
- Importin beta-like SAD2 homolog
- Telomerase reverse transcriptase
- PHD finger-like domain-containing protein 5B
- V-type proton ATPase subunit d1
- PHD finger-like domain-containing protein 5A
- Probable galacturonosyltransferase 10
- Protection of telomeres protein 1a
Sequence:
MALSTVFRRASSTVANLAFRAGRSPVSFRSGAVSVERLIRGSHQIRRGSVSSFSVSSFSTESAISKTTADENLVSVIESEIECAVAEEAPHDTDFLEDKPEGFPFEIIDNSGERTVLLTRKFEDETIQVEVDSVASYDDEDEEEEAEPNNEEDDEDQESSGKVRVPMVVSVQKGDGVCLEFGVSAYPDEIVIDSLSIKQPQGSDNDLAYEGPDFDDLDENLQKAFHRYLEIRGIKPSFTTFLADYVANKDSREYLQWLKDLKSFVEK
Protein: Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) (Q5VTE0)
Organism: Homo sapiens (Human)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFKVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHMAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
Protein: Cohesin subunit psc3 (SCC3 homolog) (O13816)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the rad21 subunit of the cohesin complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750, ECO:0000269|PubMed:11069892}. Chromosome, centromere {ECO:0000269|PubMed:11069892}. Note=Associates with chromatin. Cohesin complex mainly associates with broad centromere region. Also associates with mating-type heterochromatic region.
Interaction partners:
- Structural maintenance of chromosomes protein 1
- Structural maintenance of chromosomes protein 3
- Cohesin subunit rad21
- Meiotic recombination protein rec8
- Sister chromatid cohesion protein mis4
- Sister chromatid cohesion protein pds5
- Separin
- Meiotic recombination protein rec11
- MAU2 chromatid cohesion factor homolog
- Wings apart-like protein homolog 1
Sequence:
MSESVTTGSDDDGGDRESSPVMLSQSFDPMSSSSNSSSEENSDDDYEKTISSKKRHPRPNSKGVNVKRSRRNAIVEEDPQEEIFNNLFAFLLDQKVDTMDIAVSWFADYAKDNQSALANLINFILKCCGCNRAINVFDVQDQDSASATLSQIQLSVERTSTRDYPLNSKNLKFRNFRKRLTGLLSNFVSQLSIRNYLYNSTVFEDIMSWVVAMSSSTMRPIRHTATVFCLNIMTFLCEKSKELLNEHAIATKQLEKEEKRSRVNRNRINELNNSLGEIVKQQDTLTTYLNDYFDSVFVHRYRDVEPKIRVDCLQELGVWINTVPSIFFSGSYLRYLGWMLSDINTTVRLTVVKVLRKFFETDSFIGGLRHFSSRFKERILEMSCVDADIGVRVASIRLCNAMRTCGFLENSEILKVLKLILDINPRVQREAVLFLCKVVDESVNEKIDLWGEEDYILKAFSQTSLTTFSVHWIKFSQMCKLLEEVRLSYQSSFDYDTLLRIFQKNGNFITPITQALLNACEIDSIYQSWEDISNFVLFDNYTSTLKDPIDSILSFCKLNDFQESILLQLLSASIQTVCNNNFITPKTVHNKQAAETTNDQNKDKDLLYLNLLPYINSITERNSASPTLLHDSLRLLFSMDLTEMTDPQLSRHFELLINNLKKFFLTNNDLQIIQGCTILFLRLDSIPALKEDLKLLVTDICDQTVTEFLKNFGSFNIQDAVITKDEFVIFEACLTRIEGCTSLKDFSDYPEFDIIYERLVSLLSRVPNSYEDTLKFSAINTLQSLLFWFFLRKDNPADEEKKKDDETKVFNCLINIMNNDSSKILQLQAARTFLETVIMKEGVKASHYNDDNRVSEEHNFLKPQFLDALLKILEGWLYTYAKVGQFPFKRLTQASSPHTQISLDKNPLNRRLLEHVCCDLTSKLLIVVSLSNTITPEFSQQFCELRGHYGPKLSAIVDEFLN
Protein: Ras-related protein Rab-27B (EC 3.6.5.2) (Q99P74)
Organism: Rattus norvegicus (Rat)
Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O00194}; Lipid-anchor {ECO:0000250|UniProtKB:O00194}. Late endosome {ECO:0000250|UniProtKB:O00194}.
Interaction partners:
- Melanophilin
- Synaptotagmin-like protein 4
- CD63 antigen
- Synaptotagmin-like protein 5
- Ras-related protein Rab-27A
- Synaptotagmin-like protein 1
- Rab effector MyRIP
- Synaptotagmin-like protein 2
- Rabphilin-3A
- Vesicle-associated membrane protein 8
Sequence:
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLLDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKRMEKCVEKTQVPDTVNGVNSGKVDGEKPAEKKCAC
Protein: Keratin-associated protein 4-3 (Keratin-associated protein 4.3) (Ultrahigh sulfur keratin-associated protein 4.3) (Q9BYR4)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 9-8
- Keratin-associated protein 3-1
- Keratin-associated protein 3-2
- Keratin-associated protein 4-5
- Keratin-associated protein 4-8
- Keratin-associated protein 4-1
- Keratin-associated protein 17-1
- Keratin-associated protein 9-3
- Keratin-associated protein 2-1
- Keratin-associated protein 9-4
Sequence:
MVSSCCGSVCSDQSCGQGLGQESCCRPSCCQTTCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSCRCPFSCPTTCCRTTCFHPICCGSSCC