wanglab/gogpt-training-data huggingface dataset:
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (A0A8I6A1E0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKAAEECRLDRDEERAYVLYMKYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRKQLEEKDRREEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKIQRVNGEKSEGGAAAERGAVTAKELYTMMMDKNTSLIIMDARKIQDYQHSCILGSLSVPEEAISPGVTANWIEAKLSDDSKDTWKKRGSVDYVVLLDWFSSAKDLLLGTTLRSLKDALFKWESKAVLHHEPLVLEGGYENWLLCYPQFTTNAKVTPPPRSRPEEVSVSLDFTYPSLEEPVPSKLPAQMPPPPLEANEKAQLVTDQDGKPRPLVQSALAGPSVAPKAEASPIIQPVPATKNVPQVDRTKKPAVKLPEDHRMKSESTDQSGRVLSDRSTKPVFTSPATMLTDEEKARIHEETALLMEKNRQEKELWERQQKEQKEKLRREEQERKAGKTQDAEERDFTENQHKAKDGQEKRDSKQTKAEDREPPADGAQDATGTQRQSKSEHDASDAKVSVEGKRCPMSEVQKRPADVSSASSMSGELSAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSVPPSTPPTHKVKPQIPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPTVNRENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKSSLKKYNLFSVSVSIVSN
Protein: R2D2 (Q2Q0L0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNKSAVSALQEFCARTQINLPTYSFIPGEDGGYVCKVELLEIEALGNGRSKRDAKHLAASNILRKIQLLPGIHGLMKDSTVGDVGDELTNLNRDMVKELRDYCVRREMPLPCIEVVQQSGTPSAPEFVACCSVASIVRYGKSDKKKDARQRAAIEMLALISSNSDNLRPDQMQVASTSKLKVVDMEESMEELEASRRKKFTTYWELKEAGSVDHTGMRLCDRHNYFKNFYPTLKKEAIEAINSDEYESSKDKAMDVMSSLKITPKISEVESSSLVPLLSVELNCAFDVVLMAKETDIYDHIIDYFRTMLI
Protein: Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) (O00471)
Organism: Homo sapiens (Human)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9119050}. Midbody {ECO:0000269|PubMed:18756269}. Note=Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3. {ECO:0000269|PubMed:18756269}.
Interaction partners:
- Exocyst complex component 7
- Exocyst complex component 6
- Exocyst complex component 2
- Exocyst complex component 4
- Exocyst complex component 1
- Exocyst complex component 3
- Exocyst complex component 8
- Exocyst complex component 6B
- ADP-ribosylation factor 6
- Exocyst complex component 3-like protein
Sequence:
MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADIIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEISRMREVAAVLLHFKGYSHCVDVYIKQCQEGAYLRNDIFEDAGILCQRVNKQVGDIFSNPETVLAKLIQNVFEIKLQSFVKEQLEECRKSDAEQYLKNLYDLYTRTTNLSSKLMEFNLGTDKQTFLSKLIKSIFISYLENYIEVETGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQYTNACVKVCAYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYSCMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYRSARLARHFS
Protein: SD07884p (Q95R51)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
Interaction partners:
Sequence:
MDQQQATPPKKRRHSEYHDPDYQQTEVSSQDEEETCAEAESPGQRKWTKTEQSDGMLPLSDKFQRIRELLRLEFQREISQKVEQLAEIDRRLLQGRQLLDRLRYQVVSEYYRKQQVPLTGADIAKVRGDSLFGDDIAAPQLPLHPAIKKIVGKRPVVIQNHLPERTAATLAKETIRLRNPAHRRAERRRQQKIKEQGIVTDHSKDKKDQPEQEPPISIKLEDEQPCTSRQAHERQVELNASRLNNKNKFNFVVGNTSKYIGEDSRENGTGGNALTYKWLVYVQGKDLPEPLEKYIKKVRFHLHPSYRPNDIVDVHRSPFQLNRHGWGEFPMRIQLFFQEHLQQKPVQLMHTVVLDKTMCGLHTMGAETTVEIWLRAKQAITKQKSGKPHPPHEQETAVPAPPLAAPNVLEPSVFSFPGESCKPRTISITQNKEELDDNLFAGINKIELSDDIEKIEPTVLVSEPLKLNYSPRKQPPTPSSPPRTQLRLNAAQVTASKPSVVYLPVNGRSPRQESLPERQRQEFSPVKHYPPASPQRAWKESSSDRPPIKPVPNGHHQGKKNVVFQRAGKLYIIDPLQRKLKQAAKQQSLLKPQLSLLKPPSETRWHMLQCMQHDHGYANMSGEMDEKPMLLPPIVDTTIQSRPRRLEHIFRSAQFRNMRSAVEFLLSRLPLAAIDQQKEYPFTCITLDEFHNHTALKQRCFEYLRARMLRRCLMQHHELHKLDISGKEHYWSLREIVAFARVHGYTPALKDVLPVVHVKRKQKLSDEEQLAQRVQAQLKGEPQPQLSAYSSLSSGNRLEAWITKQSDRLLGHDQKMRDKEFIDVLGVDKPHPLASRLTNSADVSFQMVNHRQLLYLPPPKHLDSTLQLVQEMCKDINITLEPEESPPGVSQPLALSMLGQVLRTFIEKLVRRSLAAKLQQETLEQLPPAAANAPLCLQPQDIGRVISLCSELDFLGNSHLGVAPIEPQI
Protein: Uncharacterized protein (Q585V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Thioredoxin domain-containing protein
Sequence:
MKRVAQSALIARSCGTFLCSRRCSLLEHRTKGSMFMKHLDLYARRDPQLAPYLLREVDIEYKRRCRKVSFCAWICVFTAVTAVQIRMQSEQLHYMRLYADCVEAEQRAKDEDGIRRRKALVALMNVAKDAFGRNQSWGNEDQEKALKEL
Protein: Formate-dependent nitrite reductase complex subunit NrfF (P32711)
Organism: Escherichia coli (strain K12)
Function: Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase.
Subcellular location: Periplasm {ECO:0000305}.
Interaction partners:
- Formate-dependent nitrite reductase complex subunit NrfG
- Probable cytochrome c-type biogenesis protein NrfE
- Cytochrome c-type biogenesis protein CcmF
- Cytochrome c-type protein NrfB
- Thiol:disulfide interchange protein DsbE
- Cytochrome c-552
- Heme exporter protein C
- Protein NrfD
- Cytochrome c-type biogenesis protein CcmE
- Cytochrome c biogenesis ATP-binding export protein CcmA
Sequence:
MNKGLLTLLLLFTCFAHAQVVDTWQFANPQQQQQALNIASQLRCPQCQNQNLLESNAPVAVSMRHQVYSMVAEGKNEVEIIGWMTERYGDFVRYNPPLTGQTLVLWALPVVLLLLMALILWRVRAKR
Protein: Protein WHAT'S THIS FACTOR 1 homolog, chloroplastic (A0MFS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RNA-binding protein involved in group II intron splicing. Binds specific group II introns and promotes their splicing. Functions in the context of a heterodimer with the ribonuclease III domain-containing protein RNC1.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- Transcription termination factor MTERF4, chloroplastic
- CRS2-associated factor 2, chloroplastic
- Protein THYLAKOID ASSEMBLY 8, chloroplastic
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- CRM-domain containing factor CFM2, chloroplastic
- Pentatricopeptide repeat-containing protein At4g16390, chloroplastic
- Pentatricopeptide repeat-containing protein At5g42310, chloroplastic
- ATP synthase subunit b, chloroplastic
- Nuclear protein-like
Sequence:
MEPKLLLSAHKPLFVSCNSPFNEKTKLSVKSGLPMSTIRAARSQFMGEGLILGNKYGFWSTSRKTRVVVEPVRAAVKRRKELTFDSVVQRDKKLKLVLNIRKILVSQPDRMMSLRGLGKYRRDLGLKKRRRFIALLRKYPGVFEIVEEGAYSLRFKMTSEAERLYLDEMRIRNELEDVLVVKLRKLVMMSIDKRILLEKISHLKTDLGLPLEFRDTICQRYPQYFRVVPTPRGPALELTHWDPELAVSAAELSEDDNRTRESEERNLIIDRPPKFNRVKLPRGLNLSKSETRKISQFRDMQYISPYKDFSHLRSGTLEKEKHACGVIHELLSLTTEKRTLVDHLTHFREEFRFSQQLRGMLIRHPDLFYVSLKGERDSVFLREAYRNSELIDKDPLTLVKEKMRALVSVPRFPRRGGPRKDEEGREVEIDGSDADGEEEEEESDAEEWSDVDGYLEGEDGGNDDDGDWTDDEGEEDVPPNFDDDDEDEEEDSVKIGLSPSSRKSSSPRKKEEKVLTPVFPDGTPREKW
Protein: 2S seed storage protein 1 (2S albumin) (2S albumin storage protein) (Allergen Ses i 2) (Beta-globulin) (allergen Ses i 2.0101) [Cleaved into: 2S seed storage protein 1 small subunit; 2S seed storage protein 1 large subunit] (Q9XHP1)
Organism: Sesamum indicum (Oriental sesame) (Sesamum orientale)
Function: Seed storage protein.
Interaction partners:
Sequence:
MARFTIVLAVLFAAALVSASAHKTVVTTSVAEEGEEENQRGCEWESRQCQMRHCMQWMRSMRGQYEESFLRSAEANQGQFEHFRECCNELRDVKSHCRCEALRCMMRQMQQEYGMEQEMQQMQQMMQYLPRMCGMSYPTECRMRPIFA
Protein: RNA-binding region RNP-1 domain-containing protein (Q55D63)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MQSLQQQQQQQFNQLGGFTVFVGHIPSSMNEEGVSQIFNKFGNILDITIIKDKRTNVSKGCAFITFSTKEEADNALNTTNESGTFLENMNKPLQVKYSDNEIEKMERKLFIGMLGTSDEDQIRILFGNYGIIEDLNIVREKDGKPKGYGFIKYSTRDESENALREIDGKHTLPGSNLPIIVKFADTERQKRKKLLGNQQPPQNPFNFYQQNQQQQQQQQQQQQQQNQYQPFFYGQNSQMSQAMGNNGYRGYQQQPNVNFGMMQGNQAFDYNQQQQQQQQQQQPNESNDLFIYYLPFTYGDEELKQLFAPYGNVISSKVFIDKNTQQSKCFGFVSYDNTQSAIAAIQELNGRAIEGKKLKVNFKREKQF
Protein: Calmodulin-binding transcription activator 2 (Q80Y50)
Organism: Mus musculus (Mouse)
Function: Transcription activator. May act as tumor suppressor (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMEPVSWQCLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGAEEFSVEQLVQQILDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALALASISHSKPPEPPPLIAPLPPELPKAHTSPSSSSSSSSSSGFAEPLEIRPSPPTSRGGSSRGGTAILLLTGLEQRAGGLTPTRHLAPQAEPRPPVSLAVVVGSEPSAPPAPPSPAFDPDRFLNSPQRGQTYGGGQGVNPDFPEAEGTHTPCPALEPAAALEPQAAARGLAPQLGANGRRGNKFFIQDDDSGEELKGPGTVPPVPSSPPSSPSSPTALPPSGRATRGEALFGGSAGSSSELEPFSLSSFPDLMGELISDEAPGVPAPAPQLSPALNAITDFSPEWSYPEGGVKVLITGPWTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWLSLDDSQFRMSILERLEQMEKRMAEIAAAGQAPGQGPEAPPIQDEGQGPGFEARVVVLVESMIPRSTWRGPERLIHGSPFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFCWNRQALSIPDSLGRLPLSVAHSRGHVRLARCLEELQRQELSVEHPLALSPPSSSPDTGLSSASSPSELSDGTFSVTSAYSSAPDGSPPPAPPLASDISMEMIPGQLSCGAPETPLLLMDYEATNSKEPAPSPCGPPLAQDNGAAPEDADSPPAVDVIPVDMISLAKQIIDATPERIKREDFSEFPDAGASPREHTGTVGLSETMSWLASYLENVDHFPSSAPPSELPFERGRLAIPPAPSWAEFLSASTSGKMESDFALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALKFALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPHRPSGPLPARNKGTFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (NADH-ubiquinone oxidoreductase B15 subunit) (Q6IDF5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
- NADH dehydrogenase 13 kDa B subunit
- NADH dehydrogenase iron-sulfur protein 4
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- GH23780p
- NADH dehydrogenase iron-sulfur protein 6
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
Sequence:
MVLSNEEQEFIKRKHEATLKLRQEFLKQSSNPYRHATGEGGTVFDAGLARFQAMRVSNYEHFKPTGKSFRTGLFAVVLPIALYAWALKAERDGREEKYRTGQVAYKDRQFKFI
Protein: Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF) (O15525)
Organism: Homo sapiens (Human)
Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2. May be involved in signal transduction of extracellular H(+) (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:11154691}.
Interaction partners:
- Nuclear factor erythroid 2-related factor 2
- Endoplasmic reticulum membrane sensor NFE2L1
- Transcription factor NF-E2 45 kDa subunit
- Transcription regulator protein BACH2
- Transcription factor MafK
- DNA
- Nuclear factor erythroid 2-related factor 3
- Transcription factor MafF
- Transcription regulator protein BACH1
- Chromodomain-helicase-DNA-binding protein 8
Sequence:
MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS
Protein: Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (O35551)
Organism: Mus musculus (Mouse)
Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium.
Subcellular location: Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- ADP-ribosylation factor-binding protein GGA1
- Early endosome antigen 1
- ADP-ribosylation factor-binding protein GGA3
- Ras-related protein Rab-4A
- TRAF3-interacting protein 1
- Ras-related protein Rab-4B
- ADP-ribosylation factor-binding protein GGA2
- GTPase-activating protein and VPS9 domain-containing protein 1
- AP-1 complex subunit gamma-1
Sequence:
MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAIMKETVRDYEHQFHLRLEQERAQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRVNKRKDNKKTDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLMLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLKQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVEVLRELVLKYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
Protein: Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (Q7SXS7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86TU7}.
Interaction partners:
- SET domain and mariner transposase fusion protein.
- N-lysine methyltransferase SMYD2-A
- Nuclear receptor-binding SET domain protein 3.
- Ash1
- Histone-lysine N-methyltransferase SETD1B-A
- [histone H3]-lysine
- SET and MYND domain-containing 3.
- Histone-lysine N-methyltransferase SETD1A isoform X1
- Histone-lysine N-methyltransferase SETD7
- Protein-lysine N-trimethyltransferase SMYD5
Sequence:
MGKKSRVKTQKSGTGATAAVSPKEMMNLISELLQKCSSAAPSPGKEWEEYVQIRALVEKIRKKQKGMSVSFEGIREDFFSELMAWAAECRASCDGFEISNFADEGYGLKATKDIKAEELFLWIPRKMLMTVESAKNSVLGPLYSQDRILQAMGNVTLALHLLCERANPSSPWLPYIKTLPSEYDTPLYFEEEEVRHLLATQAIQDVLSQYKNTARQYAYFYKVIHTHPNASKLPLKDAFTFDDYRWAVSSVMTRQNQIPTADGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALKDYKEGEQIYIFYGTRSNAEFVIHNGFFFEDNAHDRVKIKLGVSKGERLYAMKAEVLARAGIPASSIFALHCSEPPISAQLLAFLRVFCMTEEELRDYLVGDHAINKIFTLGNTEFPVSWENEIKLWTFLETRAALLLKTYKTASEEDRSMLEKPDLSLHSRIAIKLRLAEKEILEHAVSCGRAKRLHFQKQLDEGAPLPLYEESDIALLENADAKLPIILRKLEEEEEEHVEEMNQLTPDAVCMNSSKIPVLNGQCKDLNGTQEDPPGGGAVVKEIEKHDPSAKRTEGEPKDAGK
Protein: Big defensin (P80957)
Organism: Tachypleus tridentatus (Japanese horseshoe crab)
Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:8282718, ECO:0000269|PubMed:8586631, ECO:0000269|PubMed:9165083}. Note=L- and S-granules.
Interaction partners:
Sequence:
MKGNIGIAVFYMLLLLLPTDSIGKKMEEEQEKLFRQKRNPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHEYVDTYYSAVCGRYFCCRSR
Protein: Dve (O76143)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MDFQSAMETFAEAWVAANAGQQSQALALTRAVNAAAVVASANAKSPNASSSASASLADLAVKKEHSISPPHSVVSVGVGVAGEDQHRRSSLQGVQEKLTQLQMQQQHHQQQQQQQQHQQQQQHHHHQQQAQQAGAGVGSGELAGRRSSEGTPPTAHPPTNSEGQALSSSTASSSQNATPKSDRERERERERDREERVERGSISCLPPAALGMAVGVQQAQHQEKLLSHPALDSRREFDVSKVNPKSLPLHCVVESVHSLHASLTIDTRQPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPLEQISDNPAVPVSDIVGELTSVITLRIVILRPKTSPFGEIKDKLLKLLVLQSHAVLRSTGCPLDEVTLSQICRSSHQNTYALPGGEISEELRRKFDQWWSNQLSPQATAMTPKMLPFMTGPSAVPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLANEAAHHAGAGQAPGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPNQKTRMRTSFDPEMELPKLQKWFADNPHPSRQQIQTYVVQLNALESRRGRKPLDVNNVVYWFKNARAAQKRAEMRGGSLGSAISALGHAAMNGYLSQHAPLGQNSSSSAGSQPMSMGNLSMSHDYLKSPLSLKSEDIDTMSQHSDDMDEEQSRPNTPQLPLSLTTHERHRSSPLMDEDEDEAGEQQQPQEAKSDGMNGSVKDEERQEKSRDELQDNEKENSNGEDRHLDADAQMEASSNLNNNHNNSSLHIEQEVGSTPKRSTPKEEDDDLDMDEDEEDNENDASHLDEFRSPSPDLAGGVVPHKDQLPFPMVPNSMFSQSFMYMSHYIPAFGQAAAGHPHHHAAAAAAAAGIQPNALMGGGGLNLSSISNEERRKRNRTFIDPVTEVPKLEQWFAMNTHPSHNLILKYTEDLNTMPYRQKFPRLESKNVQFWFKNRRAKCKRLKMSLYDSNQCAQLGGLGSFVPKYEERD
Protein: Rgd1p (A0A1D8PDP3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Rga2p
- GTP-binding protein RHO3
- Formin-binding protein
- Rho family GTPase
Sequence:
MSDRSVNKTDTSTNLGSSLTKTVSPPLPQPPTSIAQTDSAKLLDTDPKIQKILNSDYTIDVLLNRLKESLNTGEEFSKFIKKKAQIEDDHYNQLKKFAGHVRTNMKNNSRNLKNDSLQFQMDKIIQFDESLYGVGNSYVVALNTMYDELTSLIGTIGRTRKLIKDEHKRKEKDCIDAIITAEKAKTKYNHLCEDLDRLKTSDPNKKSFSLKNKSVEQQEDELSRKVDTADQEYKSKVATCKKLKDEILVIHRPNNTKKLKNLILEMDIALNLQLQKYATWNENLIMNSGVLISPLQSSKASMKSMASDIDNEKDLYQYLLRNGTTGDNKSLIPVDYHVHHSLVKTKDIGKPFLNTTNTPANLKSAAATNRWNNNNGSTASNIDGHSKTSSISHGAGSSMLGTSTSASGSSTVAPGKSNDTFNGHSSSATYASPPSVTESSAPVSYSSLDPAVSQTSSPSLHIKGPKPLSTFQHPTFGASIEDVIQFAGVDNVPLIVRKCIEVIESYGLNLVGIYRISSNQSQVNKLKESIDANFTNYLTIGKDIDPSNVYESEVFCVASLLKLYFSSLPEPLFTSAASKSFIETVKSTDEHFIAKKLHQLVFGLPDGAYFTLRSLMFHLNKVAQHESENRMNAKSLAIIWGPVLFNDSSTSAQDLSYKTKVVEELMAIATDIFELDE
Protein: Serine protease inhibitor (SERPIN) family protein (F4HX48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEPKEKKQKLDTSEVASPSLSKTHLKKKKTKKQKIRKSQEITSPSLSKNTDLVIASPSLSNIDVGEAMKKQNDVAIFLTGIVISSVAKNSNFVFSPASINAALTMVAASSGGEQGEELRSFILSFLKSSSTDELNAIFREIASVVLVDGSKKGGPKIAVVNGMWMDQSLSVNPLSKDLFKNFFSAAFAQVDFRSKCNVLNKLGLAVSLLESIFHISTLFDFKFALIRSAEEVRTEVNAWASSHTNGLIKDLLPRGSVTSLTDRVYGSALYFKGTWEEKYSKSMTKCKPFYLLNGTSVSVPFMSSFEKQYIAAYDGFKVLRLPYRQGRDNTNRNFAMYIYLPDKKGELDDLLERMTSTPGFLDSHNPERRVKVGKFRIPKFKIEFGFEASSAFSDFELDVSFYQKTLIEIDEKGTEAVTFTAFRSAYLGCALVKPIDFVADHPFLFLIREEQTGTVLFAGQIFDPSA
Protein: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) (P55991)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Interaction partners:
- Leucine--tRNA ligase
- Single-stranded DNA-binding protein
- DNA-directed RNA polymerase subunit alpha
- Protein RecA
- DNA polymerase I
- Beta sliding clamp
- UPF0026 protein HP_0117
- 5'-3' exonuclease domain-containing protein
- Flagellar assembly protein FliH
- Ribonuclease HI
Sequence:
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYAISSIVKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIILEPNALKDYLKPEELRLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQTESANDEADQELCEKCGGEMVQKFSRNGAFLACNNYPECKNTKSLKNTPNAKETIEGVKCPECGGDIALKRSKKGSFYGCNNYPKCNFLSNHKPINKRCEKCHYLMSERIYRKKKAHECIKCKERVFLEEDNG
Protein: NUF2 component of NDC80 kinetochore complex (B1AQT3)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, centromere {ECO:0000256|ARBA:ARBA00004584}.
Interaction partners:
Sequence:
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQY
Protein: Semaphorin-4C (Q9C0C4)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Subcellular location: Postsynaptic density membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Plexin-B2
- Plexin-B1
- Plexin-B3
- Carbohydrate sulfotransferase 10
- Plexin-D1
- Cyclic nucleotide-gated channel alpha-3
Sequence:
MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV
Protein: NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A (EC 1.-.-.-) (NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform B) (Q9VX36)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 4
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 23 kDa subunit
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6
Sequence:
MLTNCASKTLAAVRANIRAIATSSARASDNLFVHRDTPEDNPNIPFEFTAENKKRVEAILSIYPEGHKRGAMIPLLDLAQRQYGWLPISAMHKVAEILQLPNMRVYEVATFYTMFMRKPTGKYHIQVCTTTPCWLRGSDDILETCKKQLGIGVGDTTKDRKFTISEVECLGACVNAPMVAINDDYYEDLTSKDMQDILNDLKADKISPPGPRNGRFASEPKGEPTSLSEEPKGPGFGLQAGL
Protein: Mitochondrial fission regulator (H7C5V5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU369053}.
Interaction partners:
Sequence:
PHPPPPPPPLPPPALGLHQSTSAVDLIKERREKRANAGKTLVKNNPKKPEMPNMLEILKEMNSVKLRSVKRSEQDVKPKPVDATDPAALIAEALKKKFAYRYRSDSQDEVEKGIPKSESEATSERVLSLPAGFIQPHVSKHCLG