wanglab/gogpt-training-data huggingface dataset:
Protein: Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Mitochondrial editosome-like complex associated TUTase) (TbMEAT1) (C7AJA4)
Organism: Trypanosoma brucei brucei
Function: Terminal uridylyltransferase which, as part of the mitochondrial RNA editing core-like complex (RECC-like), is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA. Specifically, catalyzes the addition of U to single-stranded RNA with a preference for a 3'-terminal U and adds the number of Us specified by a guide RNA (gRNA) to precleaved double-stranded RNA editing substrates. Essential for insect and bloodstream developmental forms viability.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:19465686}.
Interaction partners:
Sequence:
MNVAKREFIRGMMAHYRASLPPPEHSVVIHELQKRVLDIGMLAVNKAHVELFGSHVSGFCTPHSDADISLTYRNFSPWLQGMERVDEQNNKRMTRFGKEASAMGMEDVRYIRARIPVVQFTDGVTGIHCDVSIGNIGGVENSKILCAIRQVFPDFYGAYIHLVKAWGKAREVIAPERSTFNSFTVTTMALMVLQELGLLPVFSKPTGEFGELTVADAEMLLQEFKLPPIYDSLHDDDEKLGEAVFFCLQRFAEYYAKYDFSAGTVSLIHPRRHRTVYERVVRRHLELLGSRKRLEWEKHIAEHKEDGPLDENDFSASMQNETTQRPSNSPYVVEDFVNYVNCGRRVQASRVRHIQQEFNRLREMLIDKESELKFDEVFRESDTVPRFQGFEGVGTRDHRVKTFRPQ
Protein: SSD domain-containing protein (Q9N2Z6)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- WaRThog
- Ground-like domain-containing protein
- Ground-like domain-containing protein
Sequence:
MEGDELVHRPTVLSTTASATSRPRHKTFELLGPVNNISLADMYKVCGKIIGRFPIAFIIATVIMCSGGLGTIGLELKDNVRDGYTPKNSLSRLENRLYREFLSSEGDPVMTTVLMTAKDGGSMHRIKYLEEAQRQWLYISKNLSADVGNGEFMKFGDFCGHYCQANDIIGYFLDAYKTKSADPKMDGYQLNYPITTVMGYQLHLERNFFGVTVNQSDPVTNIQSMKVLTLPVLSEVRTFEDTDKLNKWELAVYNYATGYSALEGDDHLVEINVIGAEVVDTEMNKDAQKMVPYFIVGIVSMIIFIFCTVSISASYYGYFSWRIGLIALACLLVPILAILTAFGINNMLGNRTNSPMMIMPFLINGIGVNDAFLTLQNWLQHSPDLPSGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLVLLLSERVNEPSKLEGTFNKVLGFYAKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETPIRKPNRIIEETVWKEFYPVTVIVNSPVDISNANALRAFDNLVHDFESMEKCRGSEYTISPIRDYQTYFYGVGAEDFDYEEETVKNTSHSLDFSKLTGFLANPIYKHHKGGLKLNFSNPVPIRKVQLIFAYENVTSWDERIQIMQDWRTIASSHVALNVSVWNVNAMFVDQMLSLKGLAISNALVTLGCMAAVCVVFIRNPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACHYQVRYKEFEEKGVLKRIEMKTPESRVVNSLSNVLWPMVQSASSTLLCVLPLGILQNYLPMVFVKTILLVVIWGMFHGLVLLPCILAQFPLSVFNKTFADLLFGRTSSSSCSSESDSETDTGDAQEMVPLAGTEKA
Protein: Si:dkey-52h23.1 protein (Q6P933)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
EPVIQTGLNRTTMESINLPTQNSGSSLETLETFSNYNESLPSPQMSSPPRQGRLIKPKPNSSCRRKREFISDEKKDASYWEKRRKNNEAAKRSREKRRLNDMVLENRVIALNDENVRLKTELLQLKLRFGLISSASYMEKTQQISNGAEAAANGANGSGATSGNPYFSSSGYSSASQVMMNSDSSEAEQSTRTERHTMLPKYSPRGSLSDMSDGSSRDSPEPINFDIKHESSGMDINRLEASVLNGMFNGHQSLGRLESNQPQEMEQQESVSNPAPPSATPQRSVILFRSGSSSYPVESQRVEDVDQQEASQTQQNGQITHFNQTGCNLPLRHDGLETLSEVAQQLARRSVDSPSYEFTNGKADAGENRRFVIQQQDLTVQGQCRSQVQDSTPNSFAPDLLNEAGKALVYQRTNPYLGTLNEEPPVLTYEGCTRADGFYQEHSSSGKDSSSSDGDPRSSDKEASTDDESPSSSSSDIGGYHATHQSASSPTMVTSDAYQYGDNQGEMKGTALPHKLRLKYRALSNGGSQDVQATTAAMSPESALPQHPYLALAQVNQQQGSSFGNKEGESETADELCTQRSPSRDKDMGWKESGKRSSGGRGNRNKKRD
Protein: Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] (P11688)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P08648}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P08648}.
Interaction partners:
- Integrin beta-1
- Fibronectin
- Integrin beta-3
- Integrin beta-2
- Vitronectin
- Integrin beta-7
- Integrin alpha-4
- Integrin beta-5
- Focal adhesion kinase 1
- Scaffold protein ILK
Sequence:
MGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQISESYYPEYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQRPAGIDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQVLQPLWAAGRTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLTSKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLDVYGEKKHVYLGDKNALNLTFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLNGVSKPEAVIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTKVTGLSNCTSNYTPNSQGLELDPETSPHHLQKREAPGRSSTASGTQVLKCPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQREYQPFSLQCEAVYEALKMPYQILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSLPYGTAMEKAQLKPPATSDA
Protein: Maltokinase (MaK) (EC 2.7.1.175) (Maltose-1-phosphate synthase) (Q7WUM3)
Organism: Actinoplanes missouriensis
Function: Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Only maltose acts effectively as phosphoryl-group acceptor, but maltotriose, maltotetraose, maltopentaose, and maltohexaose show a weak potential to replace maltose. ATP is not replaceable as phosphoryl-group donor.
Interaction partners:
Sequence:
MTLPFAEWLPKQRWYAGRSRVLASVKEASATPLGEELDLVLVDVEYTDGSSERYQVMVGWGDGPLPEYSTIASIGTADDGRDGYDALYDPRATRHLLGLVDTSATAGDVTFEKEPGVELPLEAWPRVFDAEQSNTSVIFDEDAILKLFRRVTCGVNPDIELNRVLGRAGNPHVARLLGSLQSADDSGPCSLGMVTEYAANSAEGWAMATASARDLFADAEMRADEVGGDFQGESYRLGEAVASVHRTLAEELGTGPAPFPLDAVLARVRTAAAAVPELQQFVPAITARFEALTGAEVVVQRVHGDLHLGQVLRTPEAWLLIDFEGEPGQPLDERRMPDSPLRDVAGVLRSYEYAAYQLLVDQDDDEHLAARAREWVDRNRAAFCDGYTNVAGADPREQGALLSAYELDKAVYEAAYEARHRPGWLRIPLRSITRLVG
Protein: PWP1 homolog, endonuclein (cDNA FLJ51513, highly similar to Periodic tryptophan protein 1 homolog) (B4DJV5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQSARTQARPREPLEDGDPEDDRTLDDDELAEYDLDKYDEEGDPDAETLGESLLGLTVYGSNDQDPYVTLKDTEQYEREDFLIKPSDNLIVCGRAEQDQCNLEVHVYNQEEDSFYVHHDILLSAYPLSVEWLNFDPSPDDSTGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDILGDRPSLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQKEGLRVWDISTVSSVNEAFGRRERLVLGSARNSSISGPFGSRSSDTPMES
Protein: Cytosolic carboxypeptidase 6 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6) (Q09LZ8)
Organism: Mus musculus (Mouse)
Function: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17244818}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q5VU57}. Golgi apparatus {ECO:0000250|UniProtKB:Q5VU57}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5VU57}. Note=Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. {ECO:0000250|UniProtKB:Q5VU57}.
Interaction partners:
- Tubulin monoglutamylase TTLL4
- BEN domain-containing protein 5
- Tubulin polyglutamylase TTLL6
- Tubulin--tyrosine ligase
Sequence:
MAERSQTAPEAGNDTGNEDAIGGNVNKYIVLPNGYSGQPKKGHLTFDACFESGNLGRVEQVSDFEYDLFIRPDTCNPRFRVWFNFTVENVKELQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREDDIYQFAYCYPYTYTRFQHYLDSLQKKNMDYFFREQLGQSVQQRQLDLLTITSPENLREGSEKKVIFITGRVHPGETPSSFVCQGIIDFLVSQHPIARVLREHLVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWAHPTLHGVKQLIIKMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQRQSIFPKLLCQNAEDFSYTSTSFNRDAVKAGTGRRFLGGLLDHSSYCYTLEVSFYSYIIGGTTAAVPYTEEAYMKLGRNVARTFLDYYRLNSLVEKIAVPMPRLRSKEERRLGWEHPSCLRAEQPLEVLGIPMCSGKALNEHLGNDIQWHLDCGSSTLPLGLISCSPSSSASWNDMAMSNSILLPDHSFH
Protein: Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (7-methylguanosine phosphate-specific 5'-nucleotidase) (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Lupin) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Q9D020)
Organism: Mus musculus (Mouse)
Function: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 5'
- Cytosolic 5'-nucleotidase 1A
- Cytosolic purine 5'-nucleotidase
- Cytosolic 5'-nucleotidase 1B
- 5'
- UMP-CMP kinase 2, mitochondrial
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Deoxycytidine kinase
- Uridine 5'-monophosphate synthase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sequence:
MDRAAVARVGAVASASVCAVVAGVVLAQYIFTLKRKTGRKTKIIEMMPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYNGKRCPTCHNIIDNCKLVTDECRRKLLQLKEQYYAIEVDPVLTVEEKFPYMVEWYTKSHGLLIEQGIPKAKLKEIVADSDVMLKEGYENFFGKLQQHGIPVFIFSAGIGDVLEEVIRQAGVYHSNVKVVSNFMDFDENGVLKGFKGELIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGDLRMADGVANVEHILKIGYLNDRVDELLEKYMDSYDIVLVKEESLEVVNSILQKTL
Protein: Inner centromere protein, isoform C (A0A0B4LFQ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEDILGVLGSLSDLRRELEVLRKAHFEELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQNEPEAPDATANNTSARQSTRVSNSQLLAIAEDEHNSTASLMPPPPVPVSADTTLGSGRPQRAAKLKTEKLLKEPSLNRKMRRPSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPAAETAEQQKPPEEASVTEDVNTTKTLRVKVKREKLSTEAVPPLTNAVSTANVTTVSSVTTEAARPDDTVASNTTTSTEVSKKVRKKKKDVESHRPIKVERFSDLDKSSPVSSRTRKCSSDSRTVQERSIYKDALEDPPVAEQSVAAVAPAAVNETVAISNATLVLGPAPTSDSPIGPAGDATFEVHSNDKKQPLSKQDSLLTEDESVEEKLPTTKLLSSIKAIKLPTRTHELFNPLLQSPVKMRVEAFENAANAQNSMRPKRGKDLGTPGSNNTPKIGKLPAPTVGRFFTPTQTTSTLPLSSAQPKKGPASASKATSLLKTATGTNLRSVNSTSTKTLSRENSGDDFRKGLHNLAEERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQELEELQRKMRQQEEAEALKKAKFKELEQQKLQQLTGAKPKKMLPPPPKTKYTWEMLHEDDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQLKRNSSVLWSTPPRYSELPKY
Protein: Protein SWEETIE (F4HRS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate multiple metabolic, hormonal and stress-related pathways. Required for carbohydrate metabolism and homoeostasis. May also monitor ethylene biosynthesis and senescence.
Interaction partners:
- Choline transporter-like protein
- Insulin-induced protein
- TNF receptor-associated factor homolog 1b
- Probable transcription factor At5g61620
- AP-1 complex subunit gamma-2
- AP-4 complex subunit epsilon
- AP-1 complex subunit gamma-1
Sequence:
MTKNIASDNVPLSRFGVLVAQLESIVASASQKNPDPLLCFEILSDLISAIDEEPKESLLVTQRKCEDALYSLVTLGARRPVRHLASVAMAKIISNGDSISIYSRASSLQGFLSDGKRSDPQRVAGAAQCLGELYRHFGKKITSGLFETTSIVTKLVKFNEDFVRQEAFILLHNALEGCGGTAAATAYSEAYRLITRFSTLDKSFVVRIAAARCLKAFSNIGGPGLGTSEFDTLASYCVKGIEDSESSVRDAFAEALGSLLALGMHPEAHVQPRGKGPFPPAKKLEGGLQRHLILPFTKAVGSRAKNTRFGLALSWVFFLQAIRIRYLDSDSELQDYSLPIMDMLRGDSSIDAHALACVLYILRVGVIDQMMEPSQRSFSVFLGKQLQSSNASPSMKIVALRALSYTLKTLGEVPHEFKEFFDDTVGAALSHFLDLVRVEAALTLRALAEVDPTCVGGLTSFAVTTLNALRESLSFEKGDKLKTDLASLHGQAATLAALVSISPGLSLGYPARLPRSVLEVSKKMLTESRRNVTVASSEKEAGWLLLSSLLNSMPKEEFGDQDFDILILWTDVFAGNPEHLIKQQAELKSMLSVWSAAIDALTAFVRRFVSCNDGILLQPVLANLRSALSCVSTMANKRFSDVKTLVDILIIRILIAYQSIPDPLAYKSEHQQIIQLCTTPYRDPSGFEESSCLKSLLDKRDAWLGPWIPGRDWFEDELRYFQGGEDGLAPSVWESKVSSFPLPETVKKTLVNQMVLCFGIMFASQDSQGMLSLLSVIQQCLKAGKKQQWRTASLTNICAGLLAGLKALHALRPQQLTTEVLSSGQAIFQNILTEGDICASQRRAACEGLGLLARLGNDIFTARMTRVLLGDLSGVTDPNYGGSIALALGCIHHSAGGMALSSLVPATVNSVSSLTKTSVLGLKIWALHGLLLTIEAAGLSFVSHVQAALGLALDILLTEESGWIDLSQGIGRLINAIVAVLGPELSPGSILFSRCKSVIAEISSWQEIPTLLESVCFTQQLILFAPQAVSVHIHVKNLLMTLASRQPIIRRLSVSTLRHLVEKDPVSVIDEQIEDNLFQMLDEETDSEIGNLIRSTLIRLLYATCPSRPSRWMLICRNMALAASAGRSAETSIAENDPAYTRENLGDDDEDMVSSSSGKSIRANPDKDKTLRYRTRVFAAECLSLLPEAVGNDAAHFDILLARNLASNRQSSGDWLVLQLQELISLAYQISTIQFENMRPIGVGLLSTILEKFKLVADPELPGHLLLEQYQAQLLSAVRTALDANSGPVLLEAGLQLATKIMTSGIIRSDQVAVKRIFSLLSRPLNDFNELYYPSFAEWVTSKIKIRLLAAHASLKCYIFTFLRKHHGEVPVEFEALLPMFSKSSDLLGRYWIQVLKGYSYICLCQNLKKSQCSFLDEILPHTVSRRLQPCLEEAWPVILQALVLDAIPVNHSVEEFSDRSLISTHRMVTLEAEDFQFLWGFAVLVLFQGMHPASSMQVIPFSSAKIKSSGDSSINESSFQGLKLYEIALPVFQSLSAGRFFSSGFLSIDLCQELLQVLSYSFHMDSSWDILAVSVVQQISQNCPKDFLESEEFAYSTIELCLGYLFKILHRHNEISPDDGIWDNMLSPLFISIKTLVKRFELKHRLNSAPLAFLLSGYKCIRQVPTDAYLPKALEIVKSTNDLLLELTRASSQKPYTDGTNFAADSGFHLRAIFGACLHMVGDLTRDCINGIQLVDSKRSGLRKLLQLKLVFCLEQLFSLAKLAYEFDCPVDETNTNSICIVMLKSCQISIAAVVKDSNVQVQATVLQVLKSLVQRYNNPEEKSFVILFVGELIGDIVSLMQRALLKPVNTESVVIAGECLRFIMLLQTHSITDELQKGFMSLFLEVVLVVFSKTSDGVSQEVLELRNVAVRLVSHLAQLPSSAVHFKDVLLSLPVTHRQQLQDIIRASVSKDSALAKPKSLVPAMDIKLPAPVVATPEKVTSTANMVKEEALSTMPTSFNQVSTVESGTDEEEEEEEDDDDDDWDTFQSFPASTNLEGSESKTESVAEEEPDLPGRSSIQDDESNAEETDDQHLASDHATDITREDSNDKSKEVVEEETVEPCFTTREDSVDKSKEVEEETVKPCLIEDALTSQNDKTSSGDHPVEINEQSVESKNLESENIGTDIKLASTEVESPALDDLEPQQIQKSPEDESSKEHVGADVIVTEETIAENKSDVDYI
Protein: Armadillo-like helical domain-containing protein 3 (Q5T2E6)
Organism: Homo sapiens (Human)
Function: Involved in GBF1 recruitment, Golgi maintenance and protein secretion.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:31519766}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:31519766}. Note=The majority of ARMD3 is cytosolic, with a portion colocalizing with GBF1 at juxtanuclear Golgi sites. {ECO:0000269|PubMed:31519766}.
Interaction partners:
- Phosphatidylinositol 4-kinase beta
- Golgi resident protein GCP60
Sequence:
MAQVEKRGGLLRKSSASKKPLKEKVVLMYDEIFMTEDPSKCSPRFWEELFLMKVNLEYLEGKLESLDGEELMKIKDNINCLFQHCIQALGEEHPIRVVNALQTLCALIRGVHQKNKSTSGFDIINMLMGFDKAELCMKNLMESLDSLLCAEGSESLKSLCLKLLLCLVTVTDNISQNTILEYVMINSIFEAILQILSHPPSRREHGYDAVVLLALLVNYRKYESVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIADAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKYSSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFPMDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYEIIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYERYSEQHKEAAFFKELVRSISTNVRRNLAFHTLSQEVLLKEFSTIS
Protein: Caffeoyl-CoA O-methyltransferase 1 (PhCCoAOMT1) (EC 2.1.1.104) (5-hydroxyferuloyl-CoA O-methyltransferase 1) (EC 2.1.1.-) (A0A0S2UWC9)
Organism: Petunia hybrida (Petunia)
Function: Involved in the production of floral volatile phenylpropanoids in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26) from cinnamic acid, a common precursor with the anthocyanin biosynthesis pathway involved in flower pigmentation. Methylates caffeoyl-CoA to feruloyl-CoA, also able to methylate 5-hydroxyferuloyl-CoA.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:26620524}.
Interaction partners:
Sequence:
MAENGAAVQENQNVIRHQEVGHKSLLQSDALYQYILETSVYPREPESMKELRELTAKHPWNLMTTSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALAIPHDGKILAMDINRENYEIGLPVIEKAGVAHKIDFREGPALPVLDQLVEDKNNHGTYDFIFVDADKDNYINYHKRIIDLVKVGGLIGYDNTLWNGSLVAPADTPMRKYVRYYRDFILELNKALAADPRIEICMLPVGDGITLGRRIS
Protein: Adenine/guanine permease AZG1 (AzgA-homolog protein) (Protein AZAGUANINE RESISTANT 1) (AtAzg1) (Q9SRK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transports natural purines (adenine and guanine) as well as purine analogs. Confers sensitivity to 8-azaadenine and 8-azaguanine (8-azg).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nucleobase-ascorbate transporter 12
- Nucleobase-ascorbate transporter 3
- Putative nucleobase-ascorbate transporter 9
- Cytoplasmic tRNA 2-thiolation protein 2
- Purine permease 14
- Nucleobase-ascorbate transporter 5
- Purine-uracil permease NCS1
- Nucleobase-ascorbate transporter 1
- Putative purine permease 12
- Equilibrative nucleotide transporter 1
Sequence:
MEQQQQQQLPSTTTRPKPKLLNRLNTYVGSSRVGKRFKLAERNSTFTTELRAGTATFLTMAYILAVNASILSDSGGTCSVSDCIPLCSNPAIEPSQCTGPGLRLIQPDVSCKFNPVNPGYAACVEEIRKDLIVATVAASLIGCVIMGLMANLPLALAPGMGTNAYFAYTVVGFHGSGSISYRTALAAVFIEGLIFLFISAIGFRAKLAKLVPKPVRISSSAGIGLFLAFIGLQNNQGIGLVGYSPSTLVTLAACPASSRISLAPVITSANGTVSLLAGGSVSGDIMCIHGRMESPTFWLGIVGFVIIAYCLVKNVKGAMIYGIVFVTAVSWFRNTEVTAFPNTSAGDAAHDYFKKIVDVHVIKHTAGALSFSGINKGHFWEALVTFLYVDILDTTGTLYSMARFAGFVDEKGDFAGQYFAFMSDASAIVIGSLLGTSPVTVFIESSTGIREGGRTGLTAITVAVYFLLAMFFTPLLASIPAWAVGPPLILVGVMMMKSVTEIDWEDMREAIPAFVTMILMPLTYSVAYGLIGGIGSYVVLHLWDWGEEGLVKLGFLKRKVKEEDNNNGVVKASEIDTTV
Protein: Solute carrier family 35 member E1 (H7C1I0)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
SGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSGPGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDANQQARKHLLPVTTADLSSKERHRSPLEKPHNGLLFPQHGDYQYGRNNILTDHFQYSRQSYPNSYSLNRYDV
Protein: Tumor necrosis factor (TNF-a) (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) [Cleaved into: Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] (B3GDZ6)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401, ECO:0000256|RuleBase:RU368112}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401, ECO:0000256|RuleBase:RU368112}.; SUBCELLULAR LOCATION: [C-domain 2]: Secreted {ECO:0000256|RuleBase:RU368112}.; SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted {ECO:0000256|RuleBase:RU368112}.; SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane {ECO:0000256|RuleBase:RU368112}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU368112}.; SUBCELLULAR LOCATION: [C-domain 1]: Secreted {ECO:0000256|RuleBase:RU368112}.
Interaction partners:
Sequence:
MSTESMIRDVELAEEALAKKAGGPQGSRRCLCLSLFSFLLVAGATTLFCLLHFEVIGPQKEEFPAGPLSINPLAQGLRSSSQTSDKPVAHVVANVKAEGQLQWQSGYANALLANGVKLKDNQLVVPTDGLYLIYSQVLFRGQGCPSTNVFLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKDDRLSAEINLPDYLDFAESGQVYFGIIAL
Protein: Phosphoethanolamine N-methyltransferase 1 (AtNMT1) (PEAMT1) (EC 2.1.1.103) (Protein DEFECTIVE PRIMARY ROOT 2) (Protein XIPOTL 1) (Q9FR44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine. Required for root system development and epidermal cell integrity through its role in choline and phospholipid metabolism.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Probable ethanolamine kinase
- Choline-phosphate cytidylyltransferase 1
- Probable choline kinase 3
- Choline-phosphate cytidylyltransferase 2
- Probable choline kinase 2
- Ethanolamine-phosphate cytidylyltransferase
- Probable choline kinase 1
- Phosphoethanolamine N-methyltransferase 3
- Phosphoethanolamine N-methyltransferase 2
- Phosphatidyl-N-methylethanolamine N-methyltransferase
Sequence:
MAASYEEERDIQKNYWIEHSADLTVEAMMLDSRASDLDKEERPEVLSLLPPYEGKSVLELGAGIGRFTGELAQKAGELIALDFIDNVIKKNESINGHYKNVKFMCADVTSPDLKITDGSLDLIFSNWLLMYLSDKEVELLAERMVGWIKVGGYIFFRESCFHQSGDSKRKSNPTHYREPRFYSKVFQECQTRDAAGNSFELSMIGCKCIGAYVKNKKNQNQICWIWQKVSSENDRGFQRFLDNVQYKSSGILRYERVFGQGFVSTGGLETTKEFVEKMNLKPGQKVLDVGCGIGGGDFYMAEKFDVHVVGIDLSVNMISFALERAIGLSCSVEFEVADCTTKHYPDNSFDVIYSRDTILHIQDKPALFRTFFKWLKPGGKVLISDYCRSPKTPSAEFSEYIKQRGYDLHDVQAYGQMLKDAGFTDVIAEDRTDQFMQVLKRELDRVEKEKEKFISDFSKEDYDDIVGGWKSKLERCASDEQKWGLFIANKN
Protein: DEgenerin Like (P91102)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Degenerin-like protein del-10
Sequence:
MEPTLSPNYRNEAFEHDDSYLVNFVAGSSSGESSTPPPSFVPKCNFRYNQSRSQMIIEVPVAQLKKLRKLEGTVSIKRETQHFCETTTMHGPKRIFQGKRWATLFWLIMVSCSLGLLITQVFILASEYLSKPTVSDVSFLINEDGMDFPLITICNLNPIRKTYVNEINKTGEVSPPMINYMMKWFTEIPTLIGGADRPTLHEGNEELKLYMKNHLNFTVDSFFMNSGFSCPDIFKLCSFQGEIFDCCTLSTEVLTPLGKCFTLDLSSSTKASMHKQTEPGIQAGLAITLDAHLEEQFDGSNGMDALFTNSFVNGFRYFVHPPNTIPHLSSDEFTVSPNTVAFSAISSDRYVLLPTHQWGNCTENFPDGIQSNLSYSSGNCLSLCKAKFYMENCGCTPALYNIENNLKECTPYETTTCLDNILAKPNKETGKIEFQTPNCKACAQQCNSLVYRAYNSYGSQFSAGAFHYLKSINPEWTDGHMRANFQMINIFYRDMSYTEYNQVQDASVTQLLSDIGGNMGMFLGMSVITITEICLFFSKMFWLGFSKKRRDYMYSKRVNEKTHEREVCETVEKMKAIASQGNLSSIAGTTSAKNSIPNDNVEFRINLKDLADQLDSDSGYSQNQPDSRNASFQKY
Protein: Probable aminotransferase TAT3 (EC 2.6.1.-) (Tyrosine aminotransferase 3) (Q9SK47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Arogenate dehydrogenase 1, chloroplastic
- Homocysteine S-methyltransferase 3
- Homocysteine S-methyltransferase 2
- Arogenate dehydrogenase 2, chloroplastic
- Homocysteine S-methyltransferase 1
- Phenylalanine ammonia-lyase 1
- Methionine gamma-lyase
- Phenylalanine ammonia-lyase 3
- Phenylalanine ammonia-lyase 2
Sequence:
MASNGVTNCNANANVWRFKGNGATSDAAAVTLRKLAFGMFKNCTMNSGKTILFPTPGEPSAHSNFRTCPEAEEAVAAAARSGMANSYAPSPGVFKARRAVAEYLNGELPTKLKAEDVYITGGCNQAIEIVIDSLAGNPSANILLPRPGYPHYDARAVYSGLEIRKYDLLPESDWEINLDGLEAAADENTVAMVIINPNNPCGNVYTYDHLNKVAEMARKLGIMIISDEVYDHVVYGDKPFIPMGKFASIAPVITLGSISKGWVNPGWRVGWIAMNDPNGIFVSTGVVQAIEDFLDLTPQPSFILQEALPDILEKTPKEFFEKKIKAMRRNVELSCERLKDIPCLFCPKKPESCSYLWLKLDTSMLNNIKNDFDFCTKLVSEESLILIPGVALGAENWVRISIGTDESVVQEIFDRLKGFYDRHAISKEAIKLSGHAINQIVVSVN
Protein: Insulin-like growth factor binding protein (O82760)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Bromo-adjacent homology
- Phosphoinositide phosphatase SAC2
- Homeobox-leucine zipper protein HDG3
- Lysine-specific demethylase JMJ28
- Probable methyltransferase PMT15
- Late embryogenesis abundant protein At5g17165
Sequence:
MGKKSKPFILSSDAPKPPHRQPYKALLISAQSSKVNSTDGEATGSQMKPRKQRKAPYKALLIRARSPGLSEESSSESDFSYEADCEASDSSSAESEATNMKPMKNKTARKAPEARLADKEQNKRRRISEKNNNPEETMSWEPEVKKTL
Protein: Large ribosomal subunit protein eL34z (60S ribosomal protein L34-1) (Q42351)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS24z
- Large ribosomal subunit protein eL37y
- Large ribosomal subunit protein eL8z
- Small ribosomal subunit protein eS28z/eS28y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL5z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL43y
Sequence:
MVQRLVYRSRHSYATKSNQHRIVKTPGGKLVYQTTKKRASGPKCPVTGKRIQGIPHLRPSEYKRSRLSRNRRTVNRAYGGVLSGSAVRERIIRAFLVEEQKIVKKVLKLQKAKEKVAPKA