wanglab/gogpt-training-data huggingface dataset:
Protein: Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein 1 homolog) (Urate exporter) (CD antigen CD338) (Q80W57)
Organism: Rattus norvegicus (Rat)
Function: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15255930}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18451542}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9UNQ0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP-binding cassette sub-family C member 2
- Multidrug resistance-associated protein 1
- Organic anion transporter 3
- Solute carrier family 22 member 12
- Prominin 1
- Sodium-dependent phosphate transport protein 1
- Solute carrier family 22 member 6
Sequence:
MSSSNDHVLVPMSQRNKNGLPGMSSRGARTLAEGDVLSFHHITYRVKVKSGFLVRKTAEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPRGLSGDVLINGAPQPANFKCSSGYVVQDDVVMGTLTVRENLQFSAALRLPKAMKTHEKNERINTIIKELGLDKVADSKVGTQFTRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLMFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGDSSAVMLNRGEQDHEANKTEEPSKREKPIIENLAEFYINSTIYGETKAELDQLPVAQKKKGSSAFREPVYVTSFCHQLRWIARRSFKNLLGNPQASVAQLIVTVILGLIIGALYFGLKNDPTGMQNRAGVFFFLTTNQCFTSVSAVELFVVEKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTCILYFMLGLKRTVEAFFIMMFTLIMVAYTASSMALAIAAGQSVVSVATLLMTISFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYGFTALQHNEFLGQEFCPGLNVTMNSTCVNSYTICTGNDYLINQGIDLSPWGLWRNHVALACMIIIFLTIAYLKLLFLKKYS
Protein: Fgr46p (A0A1D8PU30)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MFKTDFFFFNLCMESVLLVLFFSLLLLNKGRKKKWEKKKKKLFYSCSVQFYSVVIVVDCSVNPVKKQKKANIFQSRSIAALTTQLFNFFSCKRVYNDSSIQKYSCVDLKRIKVSSKSLAC
Protein: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) (Q16836)
Organism: Homo sapiens (Human)
Function: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:8687463}.
Interaction partners:
- Enoyl-CoA hydratase, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
- Methylglutaconyl-CoA hydratase, mitochondrial
- Enoyl-CoA hydratase domain-containing protein 2
- 3-ketoacyl-CoA thiolase, mitochondrial
- 3-ketoacyl-CoA thiolase, peroxisomal
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase, cytosolic
- Hydroxysteroid dehydrogenase-like protein 2
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
Protein: Heptaprenyl diphosphate synthase component 2 (HepPP synthase subunit 2) (EC 2.5.1.30) (P55785)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).
Interaction partners:
Sequence:
MKLKAMYSFLSDDLAAVEEELERAVQSEYGPLGEAALHLLQAGGKRIRPVFVLLAARFGQYDLERMKHVAVALELIHMASLVHDDVIDDADLRRGRPTIKAKWSNRFAMYTGDYLFARSLERMAELGNPRAHQVLAKTIVEVCRGEIEQIKDKYRFDQPLRTYLRRIRRKTALLIAASCQLGALAAGAPEPIVKRLYWFGHYVGMSFQITDDILDFTGTEEQLGKPAGSDLLQGNVTLPVLYALSDERVKAAIAAVGPETDVAEMAAVISAIKRTDAIERSYALSDRYLDKALHLLDGLPMNEARGLLRDLALYIGKRDY
Protein: Cathelicidin-1 (L8HPZ1)
Organism: Bos mutus (wild yak)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- Transcription factor p65
- 15 kDa protein A
Sequence:
METQRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQLNEQSSEPNIYRLLELDQPPQDDEDPDSPKRVSFRVKETVCSRTTQQPPEQCDFKENGLLKRCEGTVTLDQVRGNFDITCNNHQSIRITKQPWAPPQAARLCRIVVIRVCR
Protein: Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) (Q6UB35)
Organism: Homo sapiens (Human)
Function: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12937168}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- Bifunctional purine biosynthesis protein ATIC
- Formimidoyltransferase-cyclodeaminase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Methionine synthase
- Dihydrofolate reductase
- Dihydrofolate reductase 2, mitochondrial
Sequence:
MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKGLF
Protein: Protein trichome birefringence-like 15 (O80940)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Casparian strip membrane protein 2
- COBRA-like protein 10
- Probable beta-D-xylosidase 2
- Endo-1,4-beta-xylanase 4
Sequence:
MVQIVPHVANAHMVKTSRKGLLALVVVGVEECCPTRRCDLRDPNLVVDSNCLLSRSTHQSSLVEDSIIINHFRILNFNNRASIFLCLRIGVICSTQSKMYGGKSYILKGSVSLSLIILILLVTTLLVSAKNQPRISLIEVKTCNLAKGEWVEDKKRPLYSGFECKQWLSNIFSCRVMGRPDFSFEGYRWQPEGCNIPEFNRVNFLRRMQNKTIAFIGDSLGREQFQSLMCMATGGKESPEVQNVGSEYGLVIPKGAPRPGGWAYRFPTTNTTVLSYWSASLTDLVPMNNTDPPHLIAMHLDRPPAFIRNYLHRFHVLVLNTGHHWSRDKIEKNHWVMHVNGTRVEGGYFKNVENAKIFTIHSLVKWLDAQLPLHPRLKAFFTTISPRHEKCNNTIPLSRGSKITGEGGSLDTIVESAVNGTRVKILDITALSKLRDEAHIAGCKLKPKKASNVTSAPTFNDCLHWCLPGIPDTWNELLIAQL
Protein: Z band alternatively spliced PDZ-motif protein 66, isoform I (Q86BH6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEYVQFKNGSPVYYKEQPDLNECIQYQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPYKKTVQYDPRNSETYRAIQEEGGYSNYGQSSPQEVTIPVQTKVYQPNRLVPGKKPVSAPVSRPPYNVVNTHDENIRQSGSFNRLMYSVIGATEY
Protein: LRR receptor-like serine/threonine-protein kinase GSO2 (EC 2.7.11.1) (Protein EMBRYO SAC DEVELOPMENT ARREST 23) (Protein GASSHO 2) (Q9FIZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with GSO1, receptor-like serine/threonine-kinase required during the development of the epidermal surface in embryos and cotyledons. Involved in the nuclear division phase of megagametogenesis. In coordination with GSO2, regulates root growth through control of cell division and cell fate specification. Controls seedling root growth by modulating sucrose response after germination. Receptor of the peptide hormones CIF1 and CIF2 required for contiguous Casparian strip diffusion barrier formation in roots.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:C0LGQ5}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Subtilisin-like protease SBT2.4
- Transcription factor bHLH95
Sequence:
MQQNSVLLALFFLCFSSGLGSGQPGQRDDLQTLLELKNSFITNPKEEDVLRDWNSGSPSYCNWTGVTCGGREIIGLNLSGLGLTGSISPSIGRFNNLIHIDLSSNRLVGPIPTTLSNLSSSLESLHLFSNLLSGDIPSQLGSLVNLKSLKLGDNELNGTIPETFGNLVNLQMLALASCRLTGLIPSRFGRLVQLQTLILQDNELEGPIPAEIGNCTSLALFAAAFNRLNGSLPAELNRLKNLQTLNLGDNSFSGEIPSQLGDLVSIQYLNLIGNQLQGLIPKRLTELANLQTLDLSSNNLTGVIHEEFWRMNQLEFLVLAKNRLSGSLPKTICSNNTSLKQLFLSETQLSGEIPAEISNCQSLKLLDLSNNTLTGQIPDSLFQLVELTNLYLNNNSLEGTLSSSISNLTNLQEFTLYHNNLEGKVPKEIGFLGKLEIMYLYENRFSGEMPVEIGNCTRLQEIDWYGNRLSGEIPSSIGRLKDLTRLHLRENELVGNIPASLGNCHQMTVIDLADNQLSGSIPSSFGFLTALELFMIYNNSLQGNLPDSLINLKNLTRINFSSNKFNGSISPLCGSSSYLSFDVTENGFEGDIPLELGKSTNLDRLRLGKNQFTGRIPRTFGKISELSLLDISRNSLSGIIPVELGLCKKLTHIDLNNNYLSGVIPTWLGKLPLLGELKLSSNKFVGSLPTEIFSLTNILTLFLDGNSLNGSIPQEIGNLQALNALNLEENQLSGPLPSTIGKLSKLFELRLSRNALTGEIPVEIGQLQDLQSALDLSYNNFTGRIPSTISTLPKLESLDLSHNQLVGEVPGQIGDMKSLGYLNLSYNNLEGKLKKQFSRWQADAFVGNAGLCGSPLSHCNRAGSKNQRSLSPKTVVIISAISSLAAIALMVLVIILFFKQNHDLFKKVRGGNSAFSSNSSSSQAPLFSNGGAKSDIKWDDIMEATHYLNEEFMIGSGGSGKVYKAELKNGETIAVKKILWKDDLMSNKSFNREVKTLGTIRHRHLVKLMGYCSSKADGLNLLIYEYMANGSVWDWLHANENTKKKEVLGWETRLKIALGLAQGVEYLHYDCVPPIVHRDIKSSNVLLDSNIEAHLGDFGLAKILTGNYDTNTESNTMFAGSYGYIAPEYAYSLKATEKSDVYSMGIVLMEIVTGKMPTEAMFDEETDMVRWVETVLDTPPGSEAREKLIDSELKSLLPCEEEAAYQVLEIALQCTKSYPQERPSSRQASEYLLNVFNNRAASYREMQTDTDK
Protein: Sfi1 spindle body domain-containing protein (Q57U44)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMSANNCTPDGSSNSLLPLKPTISNDDADMRRRWTPLLNLLAVDSEAADGTPASLMIVAHVTYRSSLLRRALRLWVKHLEDFYRKEQWREHLASEWYGRRRLFLFFRAWQWRYNTRLQLVAKGEKAQTHCLMAAQRRAWRAWATWLFAQRAVRKAVSKLLDEIRKGTRLRFWLLWRRFSTRRVAYGRVVQQMRHQHLLRGWMQWRRLLLRGETRRLLSAVITLYTPCSWMHDVMASFQPALARQPVRLHSSSSTSRGNTLGEWYSFKLIALHFYFIQWMGETASRRGRRLLRYESAVQTVKRHVDMSSIAGRYHTWLLYTANNIHRRRILSMLCRRYFRKWTLFVSLETLFRQCQQTVYRRVKLLTLLTWRGRAQHQQEHKNLLHVADAFCARTLQEHQRRECFVCWRARLHSREEFRRLEAEVRDRRMELLRDLAVNRLLHGVLLNFCEPPNVKAADPVGGRHSPSSGVEEKTANSRKVSERYITITPNKRDGCNASVEFVEDGSNSPRNPVDAFRRKLMNQPPAIPLGFGSVAPRAAVVAQPPAHRLDSAPSVEIQSMLSTSSTLAPADLTKASPPSSHLLSFDPLPATSEDSNCTTSRPDVAEGRRLLTEYRVMLATAPSEREEMRIVRSKLDLYKLQRQRGGGLLNADDEQAEKKQVQRLISLKQRELDRQALRARVEQLAKHLEVVLRSSSVNSTAANPT
Protein: Retinitis pigmentosa GTPase regulator b (F1QEL3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAGETEDEIPESGAVFTFGKSKFADNAPSKFWLKNDVPLRISCGDEHTALVTENGKLFMFGSNNWGQLGLGTKTTVNKPTCVKALKSERVKLTACGRTHTLVFTSRGNLYACGGNNEGQLGLGDCNDRTSFHLVEFFNKQGPIKMLAAGSNTSAALTQDGRLYMWGDNSEGQIGLGKESNALTPQEVSVGKRVFWVSCGYYHSAFVTVDGALYTFGEKDSGKLGLSTEKLANHKVPQQVTDIPDRVVQVACGGGHTVALTENEVYSFGLGQFGQLGHGTFIFESRLPRVVEHFRKGRVKHAACGENHTALITDNGLLYTFGDGRHGKLGLGEENFTNQFKPTLCPRFLDYHVHSVTCGGCHMLVLAKPRTERPDDLILEEDDVTEDYLEKSYTELLGDTHSQTTLNRSLSARVRRRERERSPDQFGQMFRTLPALSGNQSASLSVPSQIRPSSKQLGKIPHNSLKTPGIRAKSFDDRSSVEDSESVKDLGETTDLLNLTHIMKMDPSDNTLTLSPMEKSLQFQTDEMRNGEAEEHEEYLDDEEEEEDEEEEEEEEEHPRGKEEEKCEEREDIADKMRKETEEQEQNTTDPDVQKKQIIEEESVPDGPMKVNSVDSDPAALKKEETWSERNEVTDDKLKTIFGSKNRLSLFKRSSTKGSQPESGTSGKPASGAPQISETRDPESSSSETQTAGQTKTSSRSRSATCSLL
Protein: tRNA(Ile)-lysidine synthase (EC 6.3.4.19) (tRNA(Ile)-2-lysyl-cytidine synthase) (tRNA(Ile)-lysidine synthetase) (P52097)
Organism: Escherichia coli (strain K12)
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. This enzyme is essential for viability.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YaeR
- tRNA-specific 2-thiouridylase MnmA
- tRNA-specific adenosine deaminase
- tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
- Isoleucine--tRNA ligase
- Hypoxanthine phosphoribosyltransferase
- tRNA pseudouridine synthase A
- tRNA modification GTPase MnmE
- tRNA sulfurtransferase
- Methionine--tRNA ligase
Sequence:
MTLTLNRQLLTSRQILVAFSGGLDSTVLLHQLVQWRTENPGVALRAIHVHHGLSANADAWVTHCENVCQQWQVPLVVERVQLAQEGLGIEAQARQARYQAFARTLLPGEVLVTAQHLDDQCETFLLALKRGSGPAGLSAMAEVSEFAGTRLIRPLLARTRGELVQWARQYDLRWIEDESNQDDSYDRNFLRLRVVPLLQQRWPHFAEATARSAALCAEQESLLDELLADDLAHCQSPQGTLQIVPMLAMSDARRAAIIRRWLAGQNAPMPSRDALVRIWQEVALAREDASPCLRLGAFEIRRYQSQLWWIKSVTGQSENIVPWQTWLQPLELPAGLGSVQLNAGGDIRPPRADEAVSVRFKAPGLLHIVGRNGGRKLKKIWQELGVPPWLRDTTPLLFYGETLIAAAGVFVTQEGVAEGENGVSFVWQKTLS
Protein: Protein E6 (P06427)
Organism: Human papillomavirus 33
Function: This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
Interaction partners:
Sequence:
MFQDTEEKPRTLHDLCQALETTIHNIELQCVECKKPLQRSEVYDFAFADLTVVYREGNPFGICKLCLRFLSKISEYRHYNYSVYGNTLEQTVKKPLNEILIRCIICQRPLCPQEKKRHVDLNKRFHNISGRWAGRCAACWRSRRRETAL
Protein: Slc5a4b protein (A0PJT9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASTLSPSITPQTEEPPVVPVRIQNAADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVFRDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACVVPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVYGTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNNTEERIDLDAEELETQEEAGGALEEDSEQSRGCLKRACCLLCGLQNTGPKLTKEEEAALRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHALK
Protein: Small ribosomal subunit protein bS16cy (30S ribosomal protein S16-1, chloroplastic) (Small subunit ribosomal protein 16) (O65686)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18453549}. Note=Not seen to be targeted to mitochondria. {ECO:0000269|PubMed:18453549}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein bL31c
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL28c
- At1g64880
- 50S ribosomal protein L33
- Small ribosomal subunit protein uS14c
- 50S ribosomal protein L20
- Small ribosomal subunit protein mS29
Sequence:
MTVKIRLARLGCKHRPFYRVVVADEKSRRDGKQIEVLGFYDPLQGKEDADRVSLKFDRIKYWLSVGAQPTDTVESMLFRAGLIPPKPMVVVGSKNGQKSTSQHVSPITGEILN
Protein: ATP synthase F(0) complex subunit 8 (A6L) (Chargerin II) (F-ATPase subunit 8) (P11608)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular location: Mitochondrion membrane; Single-pass membrane protein.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase subunit ATP5MPL, mitochondrial
- ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit d, mitochondrial
Sequence:
MPQLDTSTWFITIISSMATLFILFQLKISSQTFPAPPSPKTMATEKTNNPWESKWTKTYLPLSLPPQ
Protein: Suppressor of fused homolog (SUFUH) (Q9UMX1)
Organism: Homo sapiens (Human)
Function: Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down-regulates GLI2-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:28965847}. Nucleus {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:28965847}.
Interaction partners:
- Zinc finger protein GLI2
- Zinc finger protein GLI1
- Kinesin-like protein KIF7
- Transcriptional activator GLI3
- Protein smoothened
- Serine/threonine-protein kinase 36
- Protein patched homolog 1
- Serine/threonine-protein kinase ULK3
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit gamma
Sequence:
MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH
Protein: VWFA domain-containing protein (O45441)
Organism: Caenorhabditis elegans
Interaction partners:
- Uncharacterized protein ZK1320.2
- NIM-2 protein
- C-type lectin domain-containing protein
- C-type lectin domain-containing protein
- Saposin B-type domain-containing protein
- C-type lectin domain-containing protein
- LYSozyme
- C-type lectin domain-containing protein
- C-type lectin domain-containing protein
- C-type LECtin.
Sequence:
MLIGLLLLFLLSVTYGQVPPTDRNCGHDLANLWLDVVVVVDNSAPMTQEGLTEVAAQIVTVFGAGTRIGTNYIDKRTTRVGLVTYNTEATIQADLNRFQSPDDLFSTVFQILPNDLSTSEDVFLAKGIGAAEQLLAAGRKNNTRKNYKQMVIVYASAYNDEGEEDPRPIAERLKASGVSIATVAFDQTGDEEMIKLIGEIATPGFNFTNEDENLVKEIQTAMIQTNCYCSNLWTQYRETFEDPHSSKFGVCLRPVALTAGWTPAKFACQNMIQTGYMVTEYDQKKHDYVFKLVRNDTSFPEPYVYHIGLSYVNGGYAWQQPVGHALVPFQLNDSLWNPGFPTQSSTTTAVLNQQSSSAFRVGWQNVNQYTVSERYVCEVAACDTSTYCE
Protein: P53, isoform E (A0A0B4K7P1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKLYQLYERKQSVLREMMLQDIQIQANTLPKLENHNIGGYCFSMVLDEPPKSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLNLRVFLCFSNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSENPNSVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIGRKETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQLNSKKRKSVPEAAEEDEPSKVRRCIAIKTEDTESNDSRDCDDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHANKLLSLKKRAYELP
Protein: Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PsmB) (Q9P996)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
Interaction partners:
- Proteasome subunit alpha
- Proteasome-activating nucleotidase
- MPN domain-containing protein
- Uncharacterized sugar kinase AF_0866
- Large ribosomal subunit protein eL40
- Transcription termination factor FttA
- AAA superfamily ATPase
- Cell division control protein 48, AAA family
- Cell division cycle protein 48 homolog AF_1297
Sequence:
MSMIEEKIYKGTTTVGLVCKDGVVMATEKRATMGNFIASKAAKKIYQIADRMAMTTAGSVGDAQFLARIIKIEANLYEIRRERKPTVRAIATLTSNLLNSYRYFPYLVQLLIGGIDSEGKSIYSIDPIGGAIEEKDIVATGSGSLTAYGVLEDRFTPEIGVDEAVELAVRAIYSAMKRDSASGDGIDVVKITEDEFYQYSPEEVEQILAKFRK
Protein: FMRFamide related peptide 1 (Neuropeptide GnIH) (Neuropeptide VF like) (Neuropeptide VF precursor) (RFamide-related peptide) (Q1LW92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 3
- Prolactin-releasing hormone
- Kisspeptin
- Progonadoliberin
- Follicle-stimulating hormone beta subunit
- KISS1 receptor a
- Cytochrome b-c1 complex subunit 7
Sequence:
MSYFALLSLALGILSSFMLSEVTALRLPLSGERDLNGFTWGQFSENAQEIPRSLEIQDFTLNVAPTSGGASSPTILRLHPIIPKPAHLHANLPLRFGRDAQPGTGDRAPKSTINLPQRFGRSCTMCARSGTGPSATLPQRFGRRNIFALDPLRALALYTRTPESPSFPKERTQVHDYMFETVEDSEETVKNTDYTALD