wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Checkpoint kinase-1) (Q8AYC9)
Organism: Gallus gallus (Chicken)
Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. This inhibits their activity through proteasomal degradation, nucleo-cytoplasmic shuttling and inhibition by proteins of the 13-3-3 family. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression. May also play a role in replication fork maintenance (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O14757}. Chromosome {ECO:0000250|UniProtKB:O14757}. Cytoplasm {ECO:0000250|UniProtKB:O14757}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O14757}.
Interaction partners:
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAADCPENIKKEICINKMLNHENVVKFYGHRREGATQYLFLEYCSGGELFDRIEPDIGMPEPEAQRFFQQLIAGVVYLHSMGITHRDLKPENLLLDERDNLKISDFGLATVFKHNGRERLLNKMCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAGELPWDQPSDSCQEYSDWKERKTYLAPWRKIDSAPLALLHKILTENPTARITIPDIKKDRWYCRPLKKGTKRGRVSSGGVTESPGALPKHIRSDTDFSPVKSALGEDKASYSTSQPEPGTGGALWDSSTGSIDRLVQGISFSQPACPEHMLLNSQLLGTPGSSQSPWQRLVRRMTRFFTKLDADGSYRSLRDVCEKMGYGWKQSCTNQVTISTTDRRNNKLIFKVNLLEMESRILVDFRLSKGDGLEFKRHFLKIKGKLSDVVSTQKVWLPPP
Protein: Proton channel OTOP1 (Otopetrin-1) (Q7ZWK8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Proton-selective channel that specifically transports protons into cells (By similarity). Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (By similarity). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:15480759}; Multi-pass membrane protein {ECO:0000269|PubMed:31160780}. Cell projection, microvillus {ECO:0000250|UniProtKB:Q80VM9}. Note=Found in the gelatinous membrane overlying the inner ear macular epithelium. Also detected in the apical microvilli in inner ear supporting cells. {ECO:0000250|UniProtKB:Q80VM9}.
Interaction partners:
Sequence:
MVEHGGTDSMWLNKYNPAAASSASSSSSSDAENKLFSRLKVSLTKKYPQKNAELLSAQYGTNLLLLGVSVMLALAAQSGPVKEEHLLSFITVLMLVQLVWMLCYMIRRERERSPVPERDAHAGASWIRGGLTMLALLSLIMDAFRIGYFVGYHSCISAALGVYPIVHALHTISQVHFLWFHIKDVIKKYETFERFGVIHAVFTNLLLWCNGVMSETEHFMHNHRRRLIEMGYANLSTVDVQPHCNCTTSVCSMFSTSLYYLYPFNIEYHIFVSAMLFVMWKNIGRTLDRHSNRKRRSTGSTGLLLGPLGGLVALASSVSVLVVYLIHLEKTEEMHEAAVSMFYYYGVAMMACMCVGSGTGLLVYRMENRPMDTGSNPARTLDTELLLASSLGSWLMSWCSVVASVAEAGQKSPSFSWTSLTYSLLLVLEKCIQNLFIVESLYRRHSEEEEDAAAPQVFSVAVPPYDGILNHGYEAHDKHREAEPAAGSHALSRKQPDAPLPAGQRLDVTPGRKRQILKNICMFLFMCNISLWILPAFGCRPQYDNPLENETFGTSVWTTVLNVAIPLNLFYRMHSVASLFEVFRKV
Protein: Cell division control protein 42 (EC 3.6.5.2) (Suppressor of RHO3 protein 2) (P19073)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Protein STE50
- Serine/threonine-protein kinase CLA4
- Bud emergence protein 1
- Serine/threonine-protein kinase STE20
- Rho GDP-dissociation inhibitor
- Cell division control protein 24
- Rho-type GTPase-activating protein 1
- Protein BNI1
- High osmolarity signaling protein SHO1
- Rho-type GTPase-activating protein 2
Sequence:
MQTLKCVVVGDGAVGKTCLLISYTTNQFPADYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPSTDVFLVCFSVISPPSFENVKEKWFPEVHHHCPGVPCLVVGTQIDLRDDKVIIEKLQRQRLRPITSEQGSRLARELKAVKYVECSALTQRGLKNVFDEAIVAALEPPVIKKSKKCAIL
Protein: Succinate-acetate/proton symporter SatP (Succinate-acetate transporter protein) (P0AC98)
Organism: Escherichia coli (strain K12)
Function: Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Cation/acetate symporter ActP
- UPF0412 protein YaaI
- UPF0174 protein YaaW
Sequence:
MGNTKLANPAPLGLMGFGMTTILLNLHNVGYFALDGIILAMGIFYGGIAQIFAGLLEYKKGNTFGLTAFTSYGSFWLTLVAILLMPKLGLTDAPNAQFLGVYLGLWGVFTLFMFFGTLKGARVLQFVFFSLTVLFALLAIGNIAGNAAIIHFAGWIGLICGASAIYLAMGEVLNEQFGRTVLPIGESH
Protein: Bystin (Essential nuclear protein 1) (AtEnp1) (Q8RWS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis and pollen development. Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:23382868}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23382868}.
Interaction partners:
- Transducin family protein / WD-40 repeat family protein
- At3g13230
- RNA-binding NOB1-like protein
- Protein SLOW WALKER 1
- F18K10.11 protein
- Nucleolar protein
- rRNA biogenesis protein RRP5
- Protein TORMOZ EMBRYO DEFECTIVE
- Probable RNA 3'-terminal phosphate cyclase-like protein
- 18S rRNA
Sequence:
MAKKRDRIVNTQPFISDDASVASSRKRSKVPKTHQKQEKLIEAGMSEKIMKQALAQQKEVADEENAERNPSSAAFAVAGAATAGEEQKILEEEEDDIDDFDGTFENQSQFDKQEEINEDDEKLFESFLNKNAPPQRTLTDIIIKKLKDKDADLAEEERPDPKMDPAITKLYKGVGKFMSEYTVGKLPKAFKLVTSMEHWEDVLYLTEPEKWSPNALYQATRIFASNLKDRQVQRFYNYVLLPRVREDIRKHKKLHFALYQALKKSLYKPSAFNQGILFPLCKSGTCNLREAVIIGSILEKCSIPMLHSCVALNRLAEMDYCGTTSYFIKVLLEKKYCMPYRVLDALVAHFMRFVDDIRVMPVIWHQSLLTFVQRYKYEILKEDKEHLQTLLQRQKHHLVTPEILRELKDSRNRGEKEDPMVDNFAPVPAKEDRFDIPEVPMEED
Protein: Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) (GABAAR subunit alpha-3) (P26049)
Organism: Mus musculus (Mouse)
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein.
Interaction partners:
- Trafficking protein, kinesin binding 2
- Vesicle-fusing ATPase
- Huntingtin-associated protein 1
- Inactive phospholipase C-like protein 1
- Gamma-aminobutyric acid receptor subunit beta-2
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid receptor subunit beta-1
- Gamma-aminobutyric acid type B receptor subunit 1
- Gamma-aminobutyric acid receptor subunit gamma-2
Sequence:
MIITQMWHFYVTRVVLLLLISILPGTTSQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKNTTFNIVGTTYPINLAKDTEFSTISKSAAAPSASSTPTAIASPKATYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
Protein: Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (Q5R1S9)
Organism: Gallus gallus (Chicken)
Function: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13112}.
Interaction partners:
- Chromatin assembly factor 1 subunit A
- Histone chaperone ASF1
- Histone-binding protein RBBP4
- Proliferating cell nuclear antigen
- Histone-binding protein RBBP7
- Uncharacterized protein.
- Insulin-induced gene 1 protein
- Insulin-induced gene protein
- MORC family CW-type zinc finger 4
- Denticleless protein homolog
Sequence:
MKVITCEIAWHNKEPVYSLDFQHGTDGKINRLASAGVDTAVRVWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPSGEVLASGGDDAVILLWKLNDSKELEPLAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWTSDGNYMASASVDNTAIMWDVVKGQKVSILNEHKSYVQGITWDPLGQYIATLSCDRVLRVYNTQTKRVAFNVTKMPSESGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVTNTTYVFSRNNLKRPMGHLPCPGKATLAVRCCPVYFELRQALNKGEVSQKSSPALLNLPYRLVFAVASEDSVLFYDTEQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKPQIHVRTSVVTEKKVKKSQPNKVISPGSRLTEGTSLSTPTLQPKTPVAAAKDLPSTPVGIKNVPVSSSEERKISQPASQSTKVNQPRRITLNTLQAWSKTPRRVNLIPLKPDTPASVYTDTVPVPPSSEQEHERPLPSGDSLQNPPASKRPRTEEMPLSVSAEDQIGCKPNK
Protein: Tricarboxylate transport protein B, mitochondrial (Citrate transport protein B) (Solute carrier family 25 member 1b) (F1R4U0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate (By similarity). Required for proper neuromuscular junction formation.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZU2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Citrate synthase, mitochondrial
Sequence:
MSGSPKFVSPFHRPHCLSAAAPAGQAKLTHPGKAILAGGIAGGIEICITFPTEYVKTQLQLDEKANPPRYKGIVDCVKQTVQGHGVKGLYRGLSSLLYGSIPKAAVRFGVFEFLSNQMRDESGKLDSTRGLICGLGAGVAEAVVVVCPMETVKVKFIHDQTSANPKYRGFFHGVREIVRTQGLKGTYQGLTATVLKQGSNQAIRFYVMTALRNWYKGDNPNKSINPVVTGLFGAVAGAASVFGNTPLDVIKTRMQGLEAHKYKSTVDCAIKIMKYEGPAAFYKGTVPRLGRVCMDVAIVFIIYEEVVKVLNKVWKTD
Protein: UPF0045 protein ECM15 (Extracellular mutant protein 15) (P35195)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative uncharacterized protein YBR051W
- Uncharacterized protein YBR071W
- Putative uncharacterized protein YBL012C
- Uncharacterized protein YBR053C
- Uncharacterized glycosyl hydrolase YBR056W
Sequence:
MPKIFCLADVCMVPIGTDSASISDFVALIEKKIRESPLKSTLHSAGTTIEGPWDDVMGLIGEIHEYGHEKGYVRVHTDIRVGTRTDKHQTAQDKIDVVLKKISQ
Protein: Crb2 (Crumbs cell polarity complex component 2a) (Oko meduzy) (Protein crumbs homolog 2a) (Q1A5L2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein PALS1
- PATJ crumbs cell polarity complex component.
- Membrane protein, palmitoylated 5b
- Erythrocyte membrane protein band 4.1-like 5.
- V-myb avian myeloblastosis viral oncogene homolog-like 2b.
- Crumbs-like protein 3b.
- Protein kinase C iota type
- Par-3 family cell polarity regulator alpha, b.
- Moesin a
- Tight junction protein 1a
Sequence:
MEIRKVHLKGPGTVLLTMMMFKWGIFCSGSSDLCASSPCQNGATCVDTMDDYVCLCSREGVRYMGRDCEELYNACMFAECEGCESELGTDHYTCPEDKDECKSGPCVGPHSECVNEQNGYKCLCPPGFGGEDCSHRITDCIDEPCLNNGTCRRIVDGFECACSDGFRGETCEEDLDECDSHPCQNGAICLDGVNKYQCFCVPGYQGHNCEIDINECASRPCWNNGTCINGKDRYLCDCLLGYTGVNCELEIDECESNPCQNGATCHDLVGLYTCDCVQGFEGSDCEINIDECESGPCQNGGLCHDRIDSYECECEGTGYMGDHCEEDIPECASHPCQHGGTCLEGINHYNCSCWPGFEGGNCEVDIDECADAPCENDGECFEKSNPEHWETDWEFTYATAVGYVCQCQPGYTGENCSVNINECVSEPCHNGGSCKDLVNGYMCECPEGFTGVECEVNIDECESAPCLNGGVCEDGVAEYKCHCAEAEEGLLPWGGPQCTVQLLGCIGHECQNGATCLPWLDGETHGHTCLCPPGFYDDVCSIQTTFSFSSPRFFLIELPSLERRRRETEPEHPLGVRLRFRTTLPDMLLFFRGNAEFFLSLEIVGGELRARATSKEEGSLEAQLPGLVSDGDWHEAIVNINEHDIRLVLQVKGANCNNQACRVEDKLQDGHETFLHHDSLTKVYVGGVPEEYIGLTLSGQGFLGCMEDLQVDGHPVLPHDLGHEEESVELGCVKTEWCQEDPQPCSQQGHCVDLWTSYRCDCYRPHYGQDCSKDMPTWTFGHENSTSFLAFELLSDFGSNFSVSFFLRSLKSSGLLFQLRRSGVQGTEDEPYFTIYLEMGRLQVTSMAESPILSSPVFVSNGEKPLLQVDIQDGQVFFNHGGYRYGLGLLPDLEVLEGDLLYIGGVPGEEGATVWGGHFKGCLQDLRLDDVHLDVEDWNNTLSESIYIASDSENVLPGCTSDDTCKMEPCLNGGACTVTWNDFICSCPKDFTGKTCETRVWCVSDPCINGGHCVDLLDGFECIANATFDNTPLHYSAKGSLLDPVTNVTMKLRTRQENGVLLRAWRGEELLLIGLLDSSIHVEIHTANSVEPVKFSGQRRIADGNWHRLLFAMAHPEHDASQWFVLVDGIIDGSSAPVLAGSLNFLKDISSEVALAETFTGCLGAVRVGGVYLPFVDNTKSPQTTRFWRRPDEHVHLGCFGAPVCRSHPCRRGGTCVDLFNKFGCKCPSGWEGNICEKEIDECISGPCLHGKCKDKLNGFDCLCHPGYAGPTCSENIDDCKGSRCKNGGTCVDGVNDFTCICPPKYSGTRCQYNYPPLKCALDVECENDGVCHDTPWGANCTCPPGFTGERCEREIDECASSPCLNGGSCLDRLNRFQCLCPAGFSGQFCETNKQAQQDHIPWLAIAVPLACGCILLVAIGLIFMLMTARKKRQSEGTYSPSHQEVAGARLEMDSMLKVPPEERLI
Protein: Spermine oxidase (A0A0G2JY83)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYQLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGRRIPKDVVEEFSDLYNEVYNLTQEFFRNGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAKGIPPHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDAGEGGQSGENPQQGRWDEDEQWPVVVECEDCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAHGSSTKQQPGHLLSSKCPEQSLDPSRGSIKPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGP
Protein: SP460 (Q9U3W7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLCICPDGYVSRGKGGCKPTPGIKEVGGCISDSDCPTDKSCLNSVCRDPCNCGLNAECRIKDHKPVCTCRQGFEGNPEFECSKIECSINSDCPGTHVCRNQLCIPACQGEQCGSNAQCLAIEHRAVCECIPGHGGNARIACTPLGCRSDDECPTDKACVNGKCNDPCTTTALCAQDELCKVYHHRPQCACPPGTVPGKNGCESERHIPICISDADCPSQKACLRGECVNPCNATQPCGVNAFCSVRDTLPVRTMICECLEGYTGNPAVQCDKRSLCVIEKGFVRDVDGQCVCPPGTALDIYEYCTPCREEQGFRIDESGHCVCALERGMVIDERGRCTCPIDLGYRLTPRGECQPEEPPECTSNDQCADNRFCNLDTKTCEDPCLTKVCGVNAFCNAVNHRAQCQCITGYTGNPDLHCNHTNFRTDFPRPDMVVSCLADGVQVEIHITEPGFNGVLYVKGHSKDEECRRVVNLAGETVPRTEIFRVHFGSCGMQAVKDVASFVLVIQKHPKLVTYKAQAYNIKCVYQTGEKNVTLGFNVSMLTTAGTIANTGPPPICQMRIITNEGEEINSAEIGDNLKLQVDVEPATIYGGFARSCIAKTMEDNVQNEYLVTDENGCATDTSIFGNWEYNPDTNSLLASFNAFKFPSSDNIRFQCNIRVCFGRCQPVNCGGYNAFGRRRRSIADNSTDATAIATNSGVEGQLREEITISSNAILTFEKRSGQGLNDANIKPAAQRVEDICVSMVGLIIALVITALLTLVAVAVAVSCWLMAYRRRPKTIAPLPHPPEFPNPLFSNPDAVPEPTPDYIS
Protein: Fork head domain protein (O73843)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MGQPMSQLSYPSPTSLNRAKEVPKPYRRSLTHAKPPYSYISLITMAIQQSGSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPNSGNMFENGCYLRRQKRFKIDQEKAAKKSGKAQEGGSGKGGHGDSLMEEHSPAGGSEGADSAHSDNSHPGSSSEEQQQRSMVQLDCPPQHQSHVQSAPVAITSSTPLLHSQVMGGSPHLLPSAMHNLDLQNDPLKAMDPHYNFNHPFSITNLMSNEQKMDLKTYQDQVMAYNGYAASSPIAAKQIYDSAGPSVMDSGAYYQTLYSRSVLNAS
Protein: Canopy b (Q9VVW7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 31
- Endoplasmic reticulum-Golgi intermediate compartment protein 3
Sequence:
MLLKRLPGFVTLWVVLQLAGADSPEEEQGVRYANRCEACKILATELEARLGETGKSHDVIEIGYSVDDVKPKKRTEYRRSELRLLESLENVCERVLEYNLHKERSDSTRFAKGMSQTFQTLHGLVDKGVKVDLGIPYELWDKPPVEVTQMKTQCENLLEEYEETISEWYFKHQDEKSLKKHLCEDHVLKKKAERECLKEQLAPPEAKKAKREKAKGDKEEL
Protein: Two-component response regulator NarL (Q9HXD3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Sensor protein
- Transcriptional regulator Dnr
- Nitrite extrusion protein 1
- Oxygen sensor histidine kinase NreB
- nitrate reductase
- Transcriptional activator protein anr
- histidine kinase
- Nitrate/nitrite transporter
- nitrate reductase
- Respiratory nitrate reductase delta chain
Sequence:
MTDMPATADEPVRLLLVDDHPMMRKGVAQLLELEDDLSVVGEAGSGEEALRLAAELDPDMILLDLNMKGMNGLDTLRALREAGVDARIVVFTVSDDKGDVVNVLRAGADGYLLKDMEPERLLEHIRQAATGQMTLSPQLTQILAQALRGDDRSKSLDELTERERQILRQIAHGYSNKMIARKLDITEGTVKVHVKRVLHKLGMRSRVEAAVWAVENDLV
Protein: Interferon regulatory factor 8 (H3BRT4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPDQVFRMFPDICASHQRSFFRENQQITV
Protein: Scratch (Q7KMM2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPRCLIAKKWKAYPWLDRTEDTSNQQQQQEQSAPNSPRELEELHLKSRRSTLDDDEEIDVVGDKFLIKLEKQRTTADAAAAAATSSEAATSHSSNSSNMEASATTTTSKCWGPSSPTAGTTAPSPPPHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEITVIRAAATALVAARTSGNGSGDQHLAAYQTPPSSTTSSPSCSPSGAGDRYSPLSSGQTSSERKCFSSTGATLSLPPKKKDIYRPYSLDDKPAHGYRRRVPAEEDLHAAHAILDLSASTAFHPPTQPHQLQQQQQQQQQQHQHHHSQQQHLAPQQHHYLPLQQQQQQQAHHTHLPTLEAHAHLRSTSSIAELAAAASVVNEQRPASNASSASSNHMPSSPSSNSSSSSSQVQNENSNTTNTNPDGDGCLQDGEHSGASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGKQYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMHLLTHKLSHSCGVCGKLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNL
Protein: Putative thiosulfate sulfurtransferase, mitochondrial (EC 2.8.1.1) (Rhodanese-like protein) (Q10215)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mitochondrial tRNA-specific 2-thiouridylase 1
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein mS29
- Uncharacterized protein C15D4.13c
- Small ribosomal subunit protein mS47
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL17m
- Biotin synthase
- Large ribosomal subunit protein mL46
Sequence:
MFSKTLSVSRLLMTRSFYSSTVVKNVSIFDFEKVYNLSKRPTGDKSTVLIDVREPDEFKQGAIETSYNLPVGKIEEAMKLSDEEFSKTYGFSKPVFEDNVVVYCRSGRRSTTASDILTKLGYKNIGNYTGSWLEWSDKIKSK
Protein: Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Q90690)
Organism: Gallus gallus (Chicken)
Function: Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Homeobox protein Nkx-2.5
- Transcription factor GATA-4
- T-box transcription factor TBX5
- Paired like homeobox 2B
- T-box transcription factor TBX20
- Myocyte enhancer factor 2C.
- Transcriptional activator GLI3
- GATA-binding factor 3
- ZP domain-containing protein.
- Sonic hedgehog protein
Sequence:
MSLVGGFPHHPVVHHEGYPLRRRRCRRRRRHPLRPRGEPLLHGWLISSHPEMSPPDYSMALSYSPEYANGAPGMDHSHYGGVPPGSGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLPKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSSDKKTKGRTGWPQHVWALELKQ
Protein: Epiphycan (Dermatan sulfate proteoglycan 3) (Proteoglycan-Lb) (PG-Lb) (Small chondroitin/dermatan sulfate proteoglycan) (P70186)
Organism: Mus musculus (Mouse)
Function: May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
Subcellular location: Secreted, extracellular space, extracellular matrix. Note=Surrounding resting, proliferating, and hypertrophic chondrocytes.
Interaction partners:
Sequence:
MGMLARVALGLIIIDAVLAAPTTELFNYDSEVYDAILEDTGTFYNYEHIPDNHVENEKVSERLSGNRELLTPGPQLGDNQDEDKDEESTPRLIDGSSPQEPEFPGLLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKKTTYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPHLQELVLRDNKIKQLPELPNTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYITDNSLDHIPLPLPESLRALHLQNNDILEMHEDTFCNVKNLTYVRKALEDIRLDGNPINLSRTPQAYMCLPRLPIGSFI
Protein: Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (Retrieval from endoplasmic reticulum protein 1) (Secretory protein 22) (Suppressor of osmo-sensitivity 1) (P53622)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Interaction partners:
- Coatomer subunit epsilon
- Coatomer subunit beta'
- Coatomer subunit zeta
- Coatomer subunit delta
- Coatomer subunit gamma
- Coatomer subunit beta
- ADP-ribosylation factor GTPase-activating protein GLO3
- ADP-ribosylation factor 1
- Protein transport protein DSL1
- Protein transport protein SEC31
Sequence:
MKMLTKFESKSTRAKGIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPIFVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIACLTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLDGSLGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVIFHPHQNLIISVGEDKTLRVWDLDKRTPVKQFKRENDRFWLIAAHPHINLFGAAHDSGIMVFKLDRERPCSFIHQNQLFFVNAEKQIQSFNFQKRVASLPYASLKGIGQPWDAFRSISYNPSQHSVLVNEANGKFALVILPKQPVGAVEPTSVTQDTGNFATFVGRNRFVVYNKNTESVEVRSLENKVTRNIKVEETVRTIVAAGPGSVLVIHPREVILYDVQQGKKVSQLAVKNVKYVSWSLDGQYVALMSKHTITLATKKLELINSMHETIRIKSAAWDETGVLIYSTLNHIRYSLLNGDRGIIKTLEKTLYITKVQGKLVYCLNREGEIEILTIDPTEYRFKKALVNKNFPEVLRLIKDSNLVGQNIISYLQKSGYPEIALQFVQDPHIRFDLALEYGNLDVALDEAKKLNDSSTWERLIQEALAQGNASLAEMIYQTQHSFDKLSFLYLVTGDVNKLSKMQNIAQTREDFGSMLLNTFYNNSTKERSSIFAEGGSLPLAYAVAKANGDEAAASAFLEQAEVDEQDVTLPDQMDASNFVQRPVISKPLEKWPLKEAELSYFEKAVLGQIDDLTIDDETPAVNTTQEQEEPLGEENFNDEDIGEDEGAWDLGDEDLDVGEELPEEVEQGEITSPAQEVETAIWIKNSKLPAVLVAAGAFDAAVQALSKQVGVVKLEPLKKYFTNIYEGCRTYIPSTPCELPAQLGYVRAYDDTVSEDQILPYVPGLDVVNEKMNEGYKNFKLNKPDIAIECFREAIYRITLLMVDDAEDEKLAHKILETAREYILGLSIELERRSLKEGNTVRMLELAAYFTKAKLSPIHRTNALQVAMSQHFKHKNFLQASYFAGEFLKIISSGPRAEQARKIKNKADSMASDAIPIDFDPYAKFDICAATYKPIYEDTPSVSDPLTGSKYVITEKDKIDRIAMISKIGAPASGLRIRV