Protein: Ankyrin repeat domain-containing protein 11 (E9Q4F7)
Organism: Mus musculus (Mouse)
Function: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (By similarity). Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis.
Subcellular location: Nucleus {ECO:0000269|PubMed:25413698}. Note=Localizes to chromatin during prometaphase (By similarity). {ECO:0000250|UniProtKB:Q6UB99}.
Interaction partners:
- Nuclear receptor corepressor 1
- E3 ubiquitin-protein ligase RBBP6
Sequence:
MPKGGCSKTPQQEDFALSNDMVEKQTGKKDKDKVSLTKTPKLDRSDGGKEVRERATKRKLPFTVGANGEQKDSDTEKQGPERKRIKKEPVARKSGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDIAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKLKAKNPEPQKTVTPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKEAKANSFISIPKMEVKSYSKNNTLAPKKAAHRILSDTSDEEDVSVSIGAGEKLRLSAHTMLPGSKARESSSSRQQKEKNKLKKKRKKETKGKEVRFGKRSDKFCSSGSESESSESEEDDGDSVGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSAVAQKHGSGHTDQHTKHWRTDNWKAISSPAWSEVSSLSDSSRTGLTSESDCSSEGSSVESLKPTRRKQEHRKRGVLQSAPSEKRSSFHPCTDGAVPKLDKEGKVVKKHKTKHKHKHKEKGQCSVSQELKLKSFTYEYEDSKQKSDKAILLESDLSTENKLKVLKHDREHLKKEDKLGRMKPEDKDWLFKDEKVLKRIKDANKDMSRAFREDKDRASKAERERATKDKSPKEEKLRLYKEERKKKSKDRASRLERKNDMKEDKLSKEKEKAFKEDKEKLKKEKLYREDAAFDDYCNKSQFLDHEDTKFSLSDDQQERWFSDLSDSSFDFKGEDSWDSVTDYRDIKNDSVAKLILETVKEDSKEKKRDNKIREKRDFKDSFFRKRDRDCLDKNSEKRRDQTEKHKSIPSYLSEKDKKRRESAEGGRDRRDGRIRSEEVHREDLKECGFESSFKDKSDCDFPKNLEPWERPHAAREKEKKDALEKERKEKGRADKYKEKSSERERSDKSTLDKCQKDKEFEKCFKEKKDGKEKHKDIHSKDRKASFDQLREKKEKVFSSIISEDFSERKDDRKGKEKSWYIADIFTDESEDEKDDCVAGSFKATEASDTQRVDGLPEKEEGREHPSDRHRKSSSDRQHTEKPRDKEPKEKKKDRGASEGGKDKKEKMEKIFEKHKEKKDKECAERYKDRKERASADSAPEKKNKQKLPEKVEKKHFAEDKVKSKHKEKPEKEHSRERERKPSRGPDVEKSLLEKLEEEALHDYREDSNDKISEVSSDSFADHGQEPSLSTLLEVSFSEPPAEDKARDSACLSEKLREKERHRHSSSSSKKSHERERAKKEKAEKKEKSEDYKDSISSVRKDASQFEKDFLDAETYGVSYPTKADVEEELDKAIELFSSEKKDRSDPEREPAKRIEKELKPYGSSAISILKEKKKREKHRERWREEKERHRDKHVDGFLRHHKDEPKPAAKDKDNPPNSFKEKSREESLKLSETKLKEKFKENTEREKGDSIKMSNGNDKLVPSRDSGKKDSRPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKMRHRSGDPKLKEKKPTEDGRKKSLDFPSKKALGLDKKVKEPAPTLTTGESKPHSGPGTESKDWLSGQPLKEVLPASPRTEQSRPTGVPTPTSVVSCPSYEEVMHTPRTPSCSADDYPDLVFDCTDSQHSMPVSTASTSACSPPFFDRFSVASSVVSENAAGQTPTRPISTNLYRSISVDIRRTPEEEFSAGDKLFRQQSVPAPSSFDSPVQHLLEEKAPLPPVPAEKFACLSPGYYSPDYGIPSPKVDTLHCPPTAVVSATPPPDSVFSNLPPKSSPSPRGELLSPAIEGTLPPDLGLPLDATEDQQATAAILPQEPSYLEPLDEGPFTTVITEEPVEWTHTAAEQGLSSSSLIASASENPVSWPVGSELMLKSPQRFAESPKHFCPGESLHSTTPGPYSAAEPTYPVSPGSYPLPAPEPALEEVKDGGTGAIPVAISAAEGAAPYAAPARLESFFSNCKSHPDAPLDTAPEPTGVTAVAQVEALGPLESSFLDSNPSISTLSQVEPVSWHEAFTSPEDDLDLGPFSLPELPLQAKDASDVEAEAAKASPVPPAESPPGPTGVLGGGDVPAPAAEEPPAPPPQEASPQLSTEPEPSEEPKLDVVLEATVETEVLADDSAPEASISNSVPAPSPPQQQPPGGGDEEAETEDPSATPCCAPDGPTTDGLAQAHNSAEASCVVAAAEGPPGNVQAEATDPEPKPTSEVPKAPKVEEVPQRMTRNRAQMLASQSKQGIPAAEKDPMPTPASRAKGRASEEEDAQAQHPRKRRFQRSSQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRSNPYFEYLQIRKKIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFKQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKAQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLPA