Protein: Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) (Q9VCA8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11782402}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:26251439}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:26251439}. Note=In indirect flight muscle, more strongly associated with Z lines where it colocalizes with sls isoform A (kettin). {ECO:0000269|PubMed:26251439}.
Interaction partners:
- Chromatin-remodeling complex ATPase chain Iswi
- Protein Obscurin
- Nipped-B protein
Sequence:
MNNDAKNHESDDLNVRSTAYFNQQTTTNQPKAPATSKNNTGSGSGSNNNNNNTNQNPNRQLNHNLPRIAAARQSIAAALLKNSGRKILTAKNEPLTTTESSGVLTNTPLPSNSRLKVNNNNNTNNTAKMSGTSSSQSSATPTPPTASSSTTTTTTTNISTGGGGSGSSGGGGGSTTVIANPASVTNTGAGSAAKFRAAVASAPSPALPATNAPANATAAAAIAAIATAPAPSSSSSSSSSSKKTRAAVAALKRQVALQQQQPVTGNAPNMTSKDSAHLKFATTTLLMGAAAAAADSNAGAALGGSGAGGSGSSSSVGAVGGARMALNPAVDMANAAVLLKQKLKDAAAAASASASNRSATSSMSSTASSLSSSAGIVNAISSALQNIITPDTDTDTEFYPQPVTTDLSESEEESVSEDDIPESDPDSCPHEGEVREDEDETEEESEDSDESEGEEEEEDEEEIDVLQDNDADDEEIDDEDEEEDAPEVSSFLLDANNKRSSNISALLEAAANEKAPVLRHATHAIDETKQALTKMRCASSPRDKNSGFSRSLVAACTDNDVNTVKRLLCKGNVNLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQVEDKGQKDSTPLMEAASAGHLDIVKLLLNHNADVNAHCATGNTPLMFACAGGQVDVVKVLLKHGANVEEQNENGHTPLMEAASAGHVEVAKVLLEHGAGINTHSNEFKESALTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREGHEEMVALLLSKGANINATTEETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLVSFLLKKKANVHAETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCTVKFLIQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNADPFHKLKDNSTMLIEASKGGHTRVVELLFRYPNISPTENAASANVTQAAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGLHELSEAARASNQQHFHQQQFSSAGNGSSNIVAMGTGDFLDAGELQLTATAGMSAGAGTSTTGSETGMEEYGEVGGIDLTTLGAQQQEGLIAKSRLFHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPAAGQHQLVPCKHFDLDMEHINSLQPPQKAPPAPPVLFHTVCQQPVMQQQQQQLQPGQLKLKAMLPNRNRALKTAEVVEFIDCPVDQQQPGEQVRTQPLGEDGKTPQFACAGEDPRLQRRRGFMPELKKGELPPESSSSDPNELALKGADNNQPVPTALDNSACAQIPARNSGGAITHSSEVLQSTAISDRPKVKATNKNNRKQAAAAAAAAAAAAAAAAAAAQHAQQVLPNPMVSIYNNLHLQHLQHPHLQFQQQLQLHHQRVAGLDNAAAAAAAAASSANMAYSISPASPLPSPTGSGNYVDQQLQQQSMDVALQRKTAMDDFRGMLETAVNGPRGRKDLALNTPQLNFFKDGWHMVGVHNFFGDQPKSPTETPPEMEETTMSSPTEADRLGSEPRAEMKNLATLCSAAAAAAAVAAVNKDQVEISSDLESECEDDAEGGAGADCEENTLPPEPIELAAALREDGIIVEEEEDDEEEDDDDEEQDTNSGEVDKLNYDDEDAEVDNDGEVDYIDEDEGGGEGEEEEDDADDDEFFLDEPDSDQGTGNNNNNSKSGASSLPLKQRKMATRLENLILNSQTVCDFPPELSNSELVHVLPQISNLKAAANSNAALNSVLQQQLAAASAAAAHAKASVVHQKQQHGEGDQQCEDDGSASASELYSGLEHFANDGEMEDIFQELASSLNYPELAEFSLNQMCKGRFAGNWAQSSGKWTGQEQLVGVVRSPGLINPGDVPQDAQRQANLVLLDYPMQQNIQLEQRLLDAEEMHLQQHQQTPLSLLPFTDEQQQQLHHQALSNASDFQQHQQLALENDPELKQQLQQNSNARIIKAVAAQHQQQPPTNFVYNVESGDKNAPPVQLLFQLPPHMAQHQAQQQQGVGEPLTEQQQQQLHAEQAHLFQHRTGGQRPPTQSELEQVAQELLLQRSGQVPAGAPVVGVQAIPLKQKHFNLHPPPCPPTCVQHQVATQTHPASVVVPQPAVGYTQFALQASQQQQMQQNELSIWPMATPTPAPSSGVSSTKSMPGGIAKKAIDKQSRKERRCVVRQTPAGIQENTKLHLQPQVATAQQQFLVQNQLAVATTVSLDKTIEIDSETESNHDTALTLACAGGHEELVELLINRGANIEHRDKKGFTPLILAATAGHDKVVDILLKHSAELEAQSERTKDTPLSLACSGGRYEVVELLLSVGANKEHRNVSDYTPLSLAASGGYVNIIKLLLSHGAEINSRTGSKLGISPLMLAAMNGHTPAVKLLLDQGSDINAQIETNRNTALTLACFQGRHEVVSLLLDRRANVEHRAKTGLTPLMEAASGGYIEVGRVLLDKGADVNAAPVPTSRDTALTIAADKGHQKFVELLLSRNASVEVKNKKGNSPLWLAAHGGHLSVVELLYDHNADIDSQDNRRVSCLMAAFRKGHTKIVKWMVQYVSQFPSDQEMIRFIGTISDKELIDKCFDCMKILRSAKEAQAVKANKNASILLEELDLERTREESRKAAAARRRERKKKKKMEKKEEKRRQQQGNGPGGDDMQGDDDDASDKDDDSDKDDEDEEAAPAAAREEGDSGIDQGSCSSGDTKGARFGGSQSAQAAEAAANSVSTNSQGKKNKKQAKNKVLISVEPTQPVITSNSVLKGVCAKKHPAVEVVKQPPATQQAAPLKRQLDVKKEEPALKKKEEKNSSSSSSSKREKENLAPKEVALPAKQQPSSSSKLQSSESASNINSSTATNTSSANTTRKEVAKPASQTASATTLNPAKRTEVDGWKEVVRKSSAQQTTAVGASGAPLPVTATSSATSVQHHPHHHLANSSSNSSSSLTTSTTTAASSVPEMTCKKVQVPVNAISRVIGRGGSNINAIRATTGAHIEVEKQGKNQSERCITIKGLTDATKQAHMLILALIKDPDVDILQMLPRINSSIKQASSGGASTPMSVGTWDNRTAAGVNAYTFSSAASTTSTSSSSSASSTTPAGASYSNAHKQHQQQPQSVKGPSGRSSTSVKSNGSSTKVSASSGSGSRSGRAGSSYLAQQQPGRSSGGGSSNGVIKSKSESSSKSLPAAQKSSTTLGKSSTVSPGAQNFAKAAAIGQSSPKKAEGGATSAVVTSAGGRSSGVVAPFGRGKPVAGQGGPAATAASNVAQLGSVSGNSNILAGPIGTFNVADVAAVNAAAAAGAAAATNSNVKPIAPIAPPSKRVGSPTQVQQQHQTQQQQQQQLPQPAPVPGPQPQQQPLQQQQQQQAPQQQPQQPNQQQQPQTSQQNLVINTNLLNDLMAASAANTTSDSFSAQLAAKLSSAYSLFSDYQQSQWGKLGDPGIGGGAGAVGDGLPQADASKAPGYNRNILSSPVGSSKASSNHSTSPPVGNVIQQQQQQQPQSSQQALNIITSGPGGPATAPARSPMVSANEGNPAVGQPSMNGTQGLGETAPAHSPGVIKPPTATVPIQRHVPMPISAPEAGAPPTFGAIGSNPASGNNSAAAQAAAAAAASAMIDRQQQNLQNLQTLQNLQRMVGASQQQQPQQQLNYPMDPTSSFIVDANNVLRLNPRVIFPQGNTKPPQPPPQGGTQSNVFGGNPGRQPPGTGARQPGGAAAQRWYGGTLEYPSYTGRDMLHLENGAGGMAGMGSPSAMSPNHDDIRKMPRPIGTERAASWKYNNFNVGGPSLNMEDALASVLPPWAHELKAQPPGLQQPPPPPQSQQQQQQPLNWLKQQPQQQQYRAYNNGPYPQQQQQHEPMNMPMDYHNMQAPPNMSQQQQQHVNLMPSYGYQHFVGAPGAVDISAHMPDKMEVWDHHDKHMPWTNYTTNWSN