Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 (EC 3.1.4.11) (Egg-laying defective protein 8) (Phosphoinositide phospholipase C-beta egl-8) (Phospholipase C-beta egl-8) (PLC-beta egl-8) (G5EBH0)
Organism: Caenorhabditis elegans
Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration after injury. Plays a role in male mating behavior by regulating spicule insertion and sperm transfer. By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch. By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection. During embryogenesis, may play a role in epidermal morphogenesis together with plc-1.
Subcellular location: Perikaryon {ECO:0000269|PubMed:10571227}. Cell projection, axon {ECO:0000269|PubMed:10571227}. Synapse {ECO:0000269|PubMed:10571227}. Cell junction, adherens junction {ECO:0000269|PubMed:10571227}. Note=Present in neuronal cell somas and axon processes of the nerve ring in head ganglia. Present in the adherens junction of intestinal cells. {ECO:0000269|PubMed:10571227}.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- Inositol 1,4,5-trisphosphate receptor itr-1
- Inositol-trisphosphate 3-kinase homolog
- Probable type I inositol 1,4,5-trisphosphate 5-phosphatase
- Calcium/calmodulin-dependent protein kinase type II
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
- 1-phosphatidylinositol-5-phosphate 4-kinase
- PIPK domain-containing protein
- Synaptojanin
- Putative diacylglycerol kinase K06A1.6
Sequence:
MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLDEEDELNETPEVVGEDSVSPRSGGSGGTGAPEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNNGSNRSARSSLDTPSPSGGSLMVPDRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQRAHPEVEQPVSSSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDEAHPELKQNFIAKNLKGFGFSKKQPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDVPNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVDDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQTNVDKLITNNRRSTKKEKGSRRSLTASVSSGCGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNTQTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDKDFHKALDAEVGNYKEEQLAAQPTSVV