wanglab/gogpt-training-data huggingface dataset:
Protein: Solute carrier family 12 member 3 (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) (P55018)
Organism: Rattus norvegicus (Rat)
Function: Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption. Receptor for the pro-inflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2, either independently of IL18R1, or as a complex with IL18R1 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16887815}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P59158}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP-sensitive inward rectifier potassium channel 1
- Serine/threonine-protein kinase WNK4
- Barttin
- Serine/threonine-protein kinase WNK1
- Chloride channel protein ClC-Kb
- Claudin-16
- STE20/SPS1-related proline-alanine-rich protein kinase
- Aquaporin-2
Sequence:
MAELPVTEMPGDALCSGRFTISTLLGGDEPPPAACDNSQPSHLTHGSTLYLRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRPGHELTDGLVEDETGANSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQENGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASKDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTITPGPGLCEGLACGYGWNFTECSQQHSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIAPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATLEDYIGILHDAFDFNYGVCIMRMREGLNVSEALQTHTAPEALVQEEQTSTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQVEHTKRFEDMIAPFRLNDGFKDEATVAEMRRDYPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLSPPVLLIRGNQENVLTFYCQ
Protein: Fibroblast growth factor 4A (FGF-4A) (Embryonic fibroblast growth factor I) (xEFGF-I) (Heparin-binding growth factor 4-I) (HBGF-4-I) (P48805)
Organism: Xenopus laevis (African clawed frog)
Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Good candidate for an inducing factor with possible roles both in mesoderm induction at the blastula stage and in the formation of the anteroposterior axis at the gastrula stage.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MTVPSALVPILLLGTAAVMVQCLPLSFQRNDTVERRWETLFSRSMGEKKDTSRDSDYLLGIKRQRRLYCNVGIGFHIQVLPDGRINGMHSENRYSLLELSPVEVGVVSLYGVKSGMFVAMNAKGKLYGSRYFNEECKFKETLLPNNYNAYESRKYPGMYIALGKNGRTKKGNRVSPTMTLTHFLPRI
Protein: Transmembrane protein 180 (Major facilitator superfamily domain-containing 13A) (Q14CX5)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:31615651}; Multi-pass membrane protein {ECO:0000269|PubMed:31615651}.
Interaction partners:
Sequence:
MGLGQPQAWLLGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPRSGAGLSSRAVVLARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPGCSGLVVDSGLCGEELLVGSEEADSITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQSLITPVGSAHPWPEPPAPAPAQAPTLRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRLHMVKAQRQNLSQAQTLDVKMV
Protein: Spalt 1 (Q9DF77)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRRKQAKPQHFQSDPDLASLSQRNGDTEKGQGNRTTKNKDAHVCGRCCAEFFELSDLLQHKKNCTKNQLVLIVNENPASPPETFPPRSPSDNPDEQMNDTVNNTDQVDCSDLSERNKLDKEESMDVEASSINNSSSSSKSVNNSITSSNSSTMGTSAVTTSLPHIGDLTTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCNGASNNKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNTDMPTSSSPSQGTLRASANPLSTLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQLPQSNPGSTLIPSSSGSSPNINILAAAVTTPSSEKVASSIGGSQLSNPPVSASSSPAFAISSLLSPASNPLLPQPTPSNSIFSSPLSNIGTPAEDLNSLTALAQQRKSKPPNVTAFEAKSNSDEAFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTSTGIPYGMSIPPEKPVTSWLDSKPVLSTLTTSVGLPLPPTIPSLTPFIKTEEPQPIPISHPSASPPCSVKSDSGTADPTSKISNGLSDEVEAGALPTSNGKMEENPQNSNSVANMSSSVSSPAADSGSGSIATFTNPLMPLMSEQFKAKFPFGGLLDSTPASETSKLQQLVENIDKKATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVTENYPESMESDTGSFDDKNFDDLDNFSDENMEDCPDSSVPDTPKSADASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASLKSVENGSVEGDVLTNDSSSVGGDMESQSAGSPAVSESTSSMQALSPSNSTNDYHKSPSIEEKPVRALASEFANGLSPTPANSGALDLTSSNTDKMIKEESLSMLFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPNSSIGPNQNSSVMPANSLSSLIKTEVNGFVHSSSQDGKETPSALAASGPLSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTPARRGRRLSVDGPMTFLGGNPVKFPEMFQKDLAARSGNGDPSSFWNQYAAALSNGLAMKTNEISVIQNGGIPPPPGGLGNGGSSPISGLTGSLEKLPSSEPNAPLAGLEKMASNENGTNFRFTRFVEDNKEIVTN
Protein: Serine incorporator 2 (Tumor differentially expressed protein 2-like) (Q96SA4)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGACLGACSLLSCASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAGLLLYLWTLVAPLLLRNRDFS
Protein: Uncharacterized aarF domain-containing protein kinase At1g71810, chloroplastic (EC 2.7.-.-) (Q94BU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16461379, ECO:0000269|PubMed:22274653}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- Probable disease resistance protein At1g62630
- Protein KINASE OF THE OUTER CHLOROPLAST MEMBRANE 1
- Receptor protein kinase-like protein ZAR1
- Disease resistance RPP8-like protein 3
- Probable disease resistance protein At1g12290
- Probable disease resistance protein At1g59620
- non-specific serine/threonine protein kinase
- Protein kinase superfamily protein
Sequence:
MLRLPSSMPIVSFPANPNLLINPQPSWPSRRGNSAVVVSAASRDVDSFTSKSGYLFSLSADEADSLSEYNFPRIDGMYKKKPLILLRRLAQIGTTFSYWFGLRLADEALERSDQMFKVRAAELRKLLVELGPAYVKIAQAVSSRPDLIPPIYLDELSLLQDQITPFSTEVAFNMIEDELGLPIDELFSEISPEPVAAASLGQVYQARLRRSGKVVAVKVQRPGVRAAIALDTLILRYIAGLIKKAGRFNSDLEAVVDEWATSLFKEMDYLNEAQNGIKFRKLYGGIKDVLVPKMYTEYSTSKVLVMEWVEGQKLNEVNDLYLVEVGVYCSFNQLLEYGFYHADPHPGNFLRTYDGQLAYLDFGMMGDFRPELRDGFMEACLHLVNRDFKALAKDFVTLGLLPPTAEKSAVTKALTDVFQDAISRGVRNISFGDLLGDLGKTMYRFKFRIPPYFSLVIRSLAVLEGIAIGISPNYKVLGSTYPWIARKILTDSSPQLKSSLQNLLYEEGVFRIDRLESLLSESLRTETALVQKPVVGTESNIAMKQMLAFTFTEQGSFVREILLREFAKGLDAYGLATLDSFTFSGSGPSSSLTEEDMTNLRTFYRLISLFSGMQKAKSQVKAVSKYGEALTPLDEASLVMYQLPSAQEMLPILSILPELPQESQQRLLQLPGDLVGRLVTRAFARTIRRIFL
Protein: histidine kinase (EC 2.7.13.3) (Q9I2C9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- GfdT protein
- HPt domain-containing protein
- histidine kinase
- histidine kinase
- Porin domain-containing protein
- Response regulator EraR
- Probable chemotaxis protein
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
Sequence:
MACISTRPSPGSPLADPAEVSVAELQARVVALEEERHKLQRINQALIGRIESSAAQSDEAYGAFQYSVVLAEQVRERTDALSQTMLELKASNQLLSDARLRAETAHQHLLDAIESISDAFVLFDPQQRIVLFNERFRALWIDSRARIGPGMRRAELHRLARSGGLIVEEQRGGDQQTLYRLRDERWLRMSERPTRDGGLAVLYSDVTEIKLSETARREQALAQKSHLLQRAVDNLSQGVAMVGADGVLELWNRRFLELCGLAPIAGHRAFAEVMAESELPLLTPRSQDSQGSPLSAREQRLFDGRVLEIRTHALPTGGFVNTFTDITERYRHAEALRASERWIRLITDQVPALIAYLSDELVYEFTNKVYEEWYRWPSGSMLGRCLRDVHGAEHCRRLEPYFERALAGESVTFEIAETALSGEERYMQRSYVPNRQADGRVAGLFVLIRDITERRRTAEALHQAYQNLEQRVRERTAELTTLNDQFKREIHERSQVEARLREAKREAEQANLSKTKFLAAVSHDLLQPLNAARLFTSALQERGSATRDNEALVNNISHSLEDVENLLGTLVDISKLDAGVITPDIAPFELGELLGNLAAEYRQVAASEGLRLDFVACGALVRSDQQLLARILRNLLSNAIRYTPRGRVLLGCRRHRQRLSIEVWDTGVGIAADKLGEIFQEFKRGESQRCHQDRGLGLGLAIVDKIARMLGHRVRVGSLPGKGSCFAIEVPLARHAPRSRAEPLASADDLRERLRGSRVWVLDNDAAICAGMRTLLEAWGCRVVTALSEEDLARQVDNYHAEADLLIVDYHLDDQRNGVDAVAAINARRGSPLPALMITANYSNELKQQVRELGHTLMHKPVRPMKLKTALCHLLEREASV
Protein: Glucose-6-phosphatase 3 (G-6-Pase 3) (G6Pase 3) (EC 3.1.3.9) (Q6AZ83)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Hexokinase-3
- Hexokinase-2
- Phosphoglucomutase-1
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate isomerase
- Galactose mutarotase
- Lactase/phlorizin hydrolase
- Glucose-6-phosphatase catalytic subunit 1
- ADP-dependent glucokinase
- Beta-galactosidase
Sequence:
MESTLSAGIMMAEALQNQLPGLENMWLWVTFLADPKNLFQFYFPAVYYASRRLGISLFWIAFITEWLNLVFKWFLFGDRPFWWVHESGYSAQTPVQIHQFPSSCETGPGSPSGHCMITGAALWPVMIAISSQVASQTRSPWVRVIPGLAYCTFLLAVGLSRVFLLAHFPHQVLAGLLAGVILGWLLSPRVPMERELSFYGLTALTLMLGASLMYWTLFTLGLDLSWSINLASKWCDRPEWVLVDSRPFASLSRDSGSALGLGIALHTPCYAQIRRVHLGNGQKIACFVLAMGLLVFLEWLGHPPQISLFYIFNFLKFTLWPCLVVALVPWMVHTLSAQEAPPIRSS
Protein: Intermediate filament protein ifb-2 (Cel IF B2) (Intermediate filament protein B2) (IF-B2) (Q19286)
Organism: Caenorhabditis elegans
Function: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15063180}.
Interaction partners:
- Intermediate Filament Organize
- Moesin/ezrin/radixin homolog 1
- Intermediate filament protein ifc-2
- Intermediate filament protein ifd-1
- Protein Scribble homolog let-413
- Intermediate filament protein ifd-2
- Intermediate filament protein ifp-1
- Disks large homolog 1
- Intermediate filament protein ifc-1
- Actin
Sequence:
MSAVSYSMHRTTTTTSSSSHGGVSAGHAAEEFVASAEREKQEMQQLNSRLEVYISRVRQLEDRNKELVIELDTLRGSLGNDIGQIKFKFNDSLVKVRREISEAHSGTIGVEVKVDRLRDDLNDYRHRYEEARREVEREKTTWGGAISQAQAELDTNKSRYAAILDEEKRLYAEQDQLYLQLAAAKDELDAAIVDRRRLQAEEDDLKIELEFLGRIHSQEITELRTLLAQAPADTREFFKNELALAIREIKAEYDKIIQTTRVDLETIFQSKISAVESSIVSKNEAAVFRQEEIRKMNESITTLRAKLSELEARNSALEREANTLQIQLGEDQRAYESELHKRDNALRFMREDCQTLIAELQALLNTKQTLDTEIAIYRKLVESEEGRFTHVGQGVVVAQQETTRLVPVEQDHWDSGEVQTRSSFKRHAKGNVSIVECDPQGKYIILENTSGSVAEDVSNFEIRRVIDGVQAFVFRLPSHLVIQQHGHLKIYGRNSGGINSPPDSIVMESHPSWGQGGQVETFLYNSHGIEKASHIQTTVASSR
Protein: Zinc finger MYND domain-containing protein 10 (Protein BLu) (Q99ML0)
Organism: Mus musculus (Mouse)
Function: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6AXZ5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q6AXZ5}. Apical cell membrane {ECO:0000269|PubMed:29601588}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q5FWU8}.
Interaction partners:
- Dynein axonemal assembly factor 11
- Dynein axonemal assembly factor 5
- Dynein axonemal assembly factor 3
- Axonemal dynein light intermediate polypeptide 1
- Sperm-associated antigen 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal assembly factor 1
- Dynein axonemal assembly factor 4
- Outer dynein arm-docking complex subunit 2
- Radial spoke head 1 homolog
Sequence:
MGDLELLLPGEAEVLVRGLRSFQLREMGSEGWNKQHESLEKLNMQAILDATISQAEPIQELLINHGKIPTLVEELIAVEMWKQKVFPVLCRLEDFKPQNTFPIYMVVHHEASIINLLETVFFHKEVCESADDKVLDLVDYCHRKLILLVARKGGGDLSEEEQFQDSTPMQELQKQAEMMEFEISLKALSVLRYITDCVDSLSLSTLNRMLRTHNLPCLLVELLEHSPWSRRVGGKLQHFESGRWQTVAPSEQQKLNKLDGQVWIALYNLLLSPEARARYCLTSFAKGQLLKLQAFLTDTLLDQLPNLADLKGFLAHLSLAETQPPKKDLVLEQIPEIWDRLERENKGKWQAIAKHQLQHVFSLSEKDLRQQAQRWAETYRLDVLEAVAPERPRCGYCNAEASKRCSRCQNVWYCCRECQVKHWEKHGKTCVLAAQGDRAK
Protein: Periplasmic tail-specific protease (Q9HYY3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- AlgW protein
- Peptidoglycan D,D-transpeptidase FtsI
- Sigma factor AlgU negative regulatory protein
- GGDEF domain-containing protein
Sequence:
MKRFLPRTALLLLLGASSLPLFASTAVSVGSAQNSWDSLQPDREQVIASLNVVELLKRHHYNKPPLNDERSAKIYDSYLKMLDPARMYFTAGDIAEFDRWRNRFDDFLKSGDLDPGFVIYKRHLDRLKGRLDYALAMLDKGVDKIDFSVDESLLIDREKAPWAKDTAELDDLWRKKVKDEVLRLKITGKDDKAIQEQLTKRYKNQLSRLKQTRSEDIFQAYINAFAQSYDPHTQYLSPDNAENFDINMSLSLEGIGAVLQSDNDYVKVVRLVPAGPAAKSKQIATSDKIIGVAQGKGEMVDVVGWRLDEVVKLIRGPKGSQVRLEVIPASNAPNDQTSKIVAITREAVKLEDQAAKKSIIKVDHEGRSYKLGVIDLPAFYLDFKAYRAGDPNYKSTTRDVKKLVAELQKDKVDGIVLDLRNNGGGSLQEATELTGLFIDQGPTVLVRNSDGRVDVLNDDEGKAFYTGPLAVLVNRLSASASEIFAGAMQDYHRALILGGQTFGKGTVQTIQPLNHGELKLTLAKFYRVSGQSTQHQGVIPDISYPSIVDDKEIGESALPDSMPWDTIRPVVKDEANPFKPFLAQLKAQHDARTENNADFVYARERLALAQELMKEKTVSLNEAKRRAQQTSIENRQLAMENALRKSKGQEPLKELKREDENALPEEDDKTKPQDDAYLTESGHILLDYLNLNSAVAKH
Protein: Pleckstrin homology-like domain family B member 3 (Q6NSJ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTRRGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP
Protein: B-cell receptor-associated protein (BCR-associated protein) (A0A8I5ZX74)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367026}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367026}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSLQWTAVATFLYAEVFAVLLLCIPFISPKRWQKIFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGTAEDGGKLDVGSPEMKLEENKILKTDLKKLKDELASTKKSEDGCPDTPRSSTIHLCPMDQASVRGPSDKKEE
Protein: Precocious dissociation of sisters 5, isoform A (Precocious dissociation of sisters 5, isoform B) (RE40483p) (A1Z8S6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein wings apart-like
- Structural maintenance of chromosomes protein
- FI11703p
- LD34181p
- Nipped-B protein
- Structural maintenance of chromosomes protein
- Stromalin-2
- separase
- MAU2 chromatid cohesion factor homolog
- N-acetyltransferase eco
Sequence:
MADIVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQDDNLYQQYIPLALHLLDDFFMQHPSRDVQLLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFNMCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPYKSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLSITNKIYDIIYELNRINAGLLCSVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQSSMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTLDKKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITCLVPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRVLSQLSAKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHVQSNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAMLSYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFALIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTPNCEHQRTKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQEVPAQRDYELPEDSDWCAQEKLPPDTLCKLDALKAMARWLLGLRTDEHAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLGAACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGLYVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVHDPRFTNHEDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIKHREFSLGSDKRDNYKMWALCDLAMYIIDSKFSPFDGNTSTFSMPLALPEMYYKEPAVANFQNNDVYIPLDVYTLGAKSTSKAAATAMTTSRAAVAPKRPAEQSIMDDENPQENNLFDNIRAADTTEPMAKRTRAGAASAKS
Protein: Macro domain-containing protein (E9P885)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHNVCLVTVDRLTDLCQTLEGDWTTSSRLEMATKLYSRNLSGTTLLVPRDPMMHINSSSDFFKICEQSTDLHFDSLAEQLKKTLAANRERNSWKADKIDEETSKLIAEGKTPPEQLVPSSALRQDPTCTVGDVYITRHSNLHKVQIVYHLVVDETLQSLEINSRHPCLAGVRNIIRTAARYNTSTIHIPLLLIDRPDESTTIAWCLKRAEMLFKCVKGYLMEVCSGMDVESLPHYNVHFVLPSGLSPTIYTAITNMFPSIFHLVPGVSS
Protein: Probable peptidyl-prolyl cis-trans isomerase sll0227 (PPIase sll0227) (EC 5.2.1.8) (Rotamase sll0227) (P72704)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Interaction partners:
- Sll1033 protein
- RNA helicase CrhR
- Heat shock protein
- N
- O-succinylbenzoic acid--CoA ligase
- Slr0157 protein
- Superoxide dismutase
- Ribosome biogenesis GTPase A
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein bL21
Sequence:
MRILPNISRATWFVGIFFVVNILLTACNQPSANSSAEPSPTETNSPVAQVTTDPYKDYKPRLNGKATVEMMVNGQPIIIEVDGENAPITAGNFVDLVEQGFYNGLTFHRVVDGFVAQGGDPKGDGTGGYVDKNTQRPRNIPLEIKVDPAVENAPETPVYSRALGNQAGFPVMLPHKTGAVAMARSQMPDSASSQFYFTLSDETGFLDGDYAVFGYVTQGMDVVLKIKQGDKIQSAKVITGQNNLEK
Protein: Peptidoglycan muramidase Tse3 (Toxin Tse3) (EC 3.2.1.17) (Q9HYC5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin.
Subcellular location: Host membrane {ECO:0000269|PubMed:21776080}. Secreted {ECO:0000269|PubMed:21776080}. Note=Delivered to the target cell periplasm by the H1 type VI (H1-T6SS) secretion system. {ECO:0000269|PubMed:21776080}.
Interaction partners:
- Immune protein Tsi3
- Immune protein Tsi1
- Type VI secretion system spike protein VgrG1a
- Immune protein Tsi2
- Toxin Tse2
- Toxin protein Tse4
- Peptidoglycan amidase Tse1
- Phospholipase D
- AAA+ ATPase ClpV1
- DUF4349 domain-containing protein
Sequence:
MTATSDLIESLISYSWDDWQVTRQEARRVIAAIRNDNVPDATIAALDKSGSLIKLFQRVGPPELARSLIASIAGRTTMQRYQARNALIRSLINNPLGTQTDNWIYFPTITFFDICADLADAAGRLGFAAAGATGVASQAIQGPFSGVGATGVNPTDLPSIAFGDQLKLLNKDPATVTKYSNPLGDLGAYLSQLSPQDKLNQAQTLVGQPISTLFPDAYPGNPPSRAKVMSAAARKYDLTPQLIGAIILAEQRDQTRDEDAKDYQAAVSIKSANTSIGLGQVVVSTAIKYELFTDLLGQPVRRGLSRKAVATLLASDEFNIFATARYIRYVANLASQQDLRKLPKTRGAFPSIDLRAYAGNPRNWPRDNVRALASEYTSRPWDDNLSPGWPMFVDDAYATFLDPGMRFP
Protein: Vimentin-type intermediate filament-associated coiled-coil protein (Q6QZQ4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14985129}. Note=Colocalizes with vimentin-type intermediate filaments.
Interaction partners:
Sequence:
MSAPPPLQIREANAHLAAVHRRAAELERRLLAAERTMRAQAERLACQDQQLRAALDELGRAKDREIFTLQEQLLSSEATVRSLQAAVEQRDQMIQELQPRADLLQDITRQRPPLAALLATLEEAEELGPLPSSHSHGAQLLPDGPGPPLGNSMREEEGQDDQQPAVFGTTV
Protein: Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) (O54833)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:28355567}. Cytoplasm {ECO:0000269|PubMed:28355567}. Note=Interaction with SIRT6 prevents translocation into the nucleus. {ECO:0000269|PubMed:28355567}.
Interaction partners:
- Casein kinase II subunit beta
- Cellular tumor antigen p53
- Catenin beta-1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Casein kinase II subunit alpha
- Segment polarity protein dishevelled homolog DVL-1
- FUN14 domain-containing protein 1
- E3 ubiquitin-protein ligase RING2
- NF-kappa-B inhibitor alpha
- Segment polarity protein dishevelled homolog DVL-2
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAENTVLSSGLTAAR
Protein: Probable ATP-dependent RNA helicase prh1 (EC 3.6.4.13) (Q03319)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in pre-mRNA splicing.
Interaction partners:
- U3 small nucleolar RNA-associated protein 21 homolog
- Uncharacterized protein C13G1.09
- U3 small nucleolar RNA-associated protein 25
- ATP-dependent RNA helicase dbp8
- U3 small nucleolar ribonucleoprotein protein imp3
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43
- Uncharacterized WD repeat-containing protein C2E1P5.05
- U3 small nucleolar ribonucleoprotein protein imp4
- U3 small nucleolar RNA-associated protein 22
- Putative ATP-dependent RNA helicase PB1A10.06c
Sequence:
MVKVSGKLRNGGSITKQNLTDGLVGGQRIKAPNKKKNRKASKNTTKKSTVSVVNFLEQDTDFGANEVVGSDNSSPEKRSENSPSKRKDILEQRKNLPIWEAHDTLCQQIQDNRVIVVVGETGSGKSTQIPQFLNECPYAQEGCVAITQPRRVAAVNLAKRVAAEQGCRLGEQVGYSIRFDDTTSKKTRIKYLTDGMLLRELINDPILSQYHTLILDEAHERTLMTDMLLGFVKKIIKKRPALRVIIMSATLNAERFSEFFDGAEICYISGRQYPVQIHYTYTPEPDYLDACLRTIFQLHTKLPPGDILVFLTGQDEIEALEALIKSYSKQLPSNLPQIQACPLFASLPQEQQLQVFLPALANHRKVVLSTNIAETSVTISGIRYVIDTGLAKIKQFNSKLGLESLTVQPISQSAAMQRSGRAGREAAGQCYRIYTEADFDKLPKETIPEIKRIDLSQAVLTLKARGQNDVINFHYMDPPSKEGLLRALEHLYSIGALDDNGHINDLGYQMSLIPLLPSLARAVLAAREHNCLSEVIDVVSCLSTDSMFLFPQEKRDEAIEARLKFLHSEGDLLTCLNALRQYLESSHDSRKQWCSQNFINRRALKTILDIRKQLREHCLKDGWELNSSPEVNSENLLLSFLSGYITNTALLHPDGSYRTIIGNQTISIHPSSSLFGKKVEAIMYHELVFTTKSYVRGVSSIRSNWLNAVAPHYLARRST