wanglab/gogpt-training-data huggingface dataset:
Protein: Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK homolog) (P54823)
Organism: Mus musculus (Mouse)
Function: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (By similarity). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular location: Cytoplasm, P-body {ECO:0000250|UniProtKB:P26196}. Cytoplasm {ECO:0000250|UniProtKB:P26196}. Nucleus {ECO:0000250|UniProtKB:P26196}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:37083226}. Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism. Upon cellular stress, relocalizes to stress granules. {ECO:0000250|UniProtKB:P26196}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- Enhancer of mRNA-decapping protein 3
- mRNA-decapping enzyme 1A
- U6 snRNA-associated Sm-like protein LSm7
- Protein PAT1 homolog 1
- U6 snRNA-associated Sm-like protein LSm1
- Eukaryotic translation initiation factor 4E transporter
- m7GpppN-mRNA hydrolase
- mRNA-decapping enzyme 1B
- Protein argonaute-2
Sequence:
MSTARTENPVIMGLSSQNGQLRGPVKASAGPGGGGTQPQPQLNQLKNTSTINNGTPQQAQSMAATIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPAEDEKP
Protein: Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Q9Z1C8)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity).
Subcellular location: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Adenylate cyclase type 5
- Ras-related protein Rap-1b
- Adenylate cyclase type 6
- Ras-related protein Rap-1A
- Adenylate cyclase type 8
- Adenylate cyclase type 1
- Beta-arrestin-2
- Mitogen-activated protein kinase 7
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
Sequence:
MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEGSLDFRVSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRKYHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELVEAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEELVHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTRGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYSPMLRSDPVATSFLQKLSDLVSRDTRLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
Protein: Semaphorin-3E (Collapsin-5) (COLL-5) (O42237)
Organism: Gallus gallus (Chicken)
Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Plexin-D1
- Neuropilin-1
- Plexin A1.
- Plexin-A4
- Sema domain-containing protein.
- Plexin C1.
- Vascular endothelial growth factor receptor 2
Sequence:
MLGRMASAQDLLILALCGLLLELPAGYHATDTRQPRLRLSHKELWDLNRTSVFHSPFGYLGLHIMLLDEYQERLFVGGRDLLYSLSLDRISNNYREIHWPSTPLQAEECIIKGRDADECANYVRVLHRYNRTHLLACGTGAFDPVCTFIRVGHPSEDHLFQLESHKFERGRGRCPFDPTSSFTSILIGGELFTGLYSDYWGRDAAVFRTMNRMAHLRTEPDSEHLLKEPKFVGSYMIPDNEDHDDNKVYLFFTEKALEAETSTHAIYTRVGRVCVNDMGGQRIVVNKWSTFLKTRLVCSVPGRNGIDTHFDELEDVFLLQTRDNKNPVIFGLFSTTSNIFRGYAICVYHMAIVRAAFNGPYAHKEGPEYYWALYEGKVPYPRPGSCASKVNGGLYTTTKDYPDEAVHFARSHPLMYQPIKPVHKRPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQETESMEEVILEELQVFKVPIPILSMEISSKRQQLYIGTESVIAQVKFHQCDMYGTACADCCLARDPYCAWDGISCSRYYPTGMQAKRRFRRQDVRHGNAAQQCFGQQFIGEVLEKTEERLVYGIEYNSTLLEYTPRTLQAKVNWFVQRAHETKKEEVKTDERIIKMDLGLLFLKLHRLDAGTYFCQTVEHSIVHTVRKITLEIVEEERVDEMFSKDYEEEISHKMPCPMQSNIPQVSKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDKKRKKLKMSPSKWKYANPQEKRQDQEKKARIRPEHYRLPRNIADS
Protein: AT27578p (LD31194p) (Rasputin, isoform B (EC 3.6.4.13)) (Rasputin, isoform E) (Rasputin, isoform F) (Rasputin, isoform G) (Q9VFT4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, Stress granule {ECO:0000256|ARBA:ARBA00004210}.
Interaction partners:
- ubiquitinyl hydrolase 1
- Caprin homolog
- tRNA selenocysteine-associated protein 1
- Protein lingerer
- Ataxin-2 homolog
Sequence:
MVMDATQSQQPSPQSVGREFVRQYYTLLNKAPNHLHRFYNHNSSYIHGESKLVVGQREIHNRIQQLNFNDCHAKISQVDAQATLGNGVVVQVTGELSNDGQPMRRFTQTFVLAAQSPKKYYVHNDIFRYQDLYIEDEQDGESRSENDEEHDVQVVGGTVDQAVQVAGDVVAQQPQQQQAPPQPQAQVVVPQQVAPVAAGGAAPQQIFYPLPAGAAAGRPVAVLPPAPQAAAVPLPAQFTVPPPQPIQNGVVSHEELQQQQVLVPPSVSPLVQQQQPTGTPVLPIVPVPSAGFQQSPLVAPQLIQQQQQQQPAQLPPQQQQQQQPIQQQQPLQQQQQPLAEPEEVEVAPRQQKPPTPVEDFKTIHEQQQQEKYEAAKQQQNEPKTYANLFKSTSSSPSGFVNAALQQQQQLQQQQQQQQSISSNTYNSSSATSGGGNGSQVSYSTTASSYNNSNGNSRLDNGGPLPQRNNSIRNNKGDFEQRRSSNTQQFGDNQQLFLGNIPHHASEDDLREIFSRFGNVLELRILSKAGNKVPPGMRSPLNYGFITYDDPEAVQKCLANCPLYFPENSPDGQKLNVEEKKPRVRNDMVPRQQIGGNNLNNNMGRLGGNNGPQSRPMGNNNGSGGGMMRNNAGGNNLRQGGGGGNGAPRLGGGGGFGQRQDNRTGGGNNQSNGPLRGAGNGQSGGGNYGRR
Protein: ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Golgi to ER traffic protein 3) (Guided entry of tail-anchored proteins 3) (Q12154)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
Subcellular location: Cytoplasm. Endoplasmic reticulum {ECO:0000269|PubMed:24392163}. Golgi apparatus. Note=GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.
Interaction partners:
- Golgi to ER traffic protein 4
- Ubiquitin-like protein MDY2
- Golgi to ER traffic protein 1
- Golgi to ER traffic protein 2
- Small glutamine-rich tetratricopeptide repeat-containing protein 2
- Protein transport protein SEC22
- Integral membrane protein SED5
- Protein transport protein SBH1
- SRP-independent targeting protein 2
- Signal recognition particle subunit SRP54
Sequence:
MDLTVEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSLLQGGALADLTGSIPGIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITNKLGPMLNSFMGAGNVDISGKLNELKANVETIRQQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLTKFSQFLNKEYNPITDGKVIYELEDKE
Protein: Golden goal (RE53634p) (Q9VWA7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protocadherin-like wing polarity protein stan
Sequence:
MRKNSKEMAANRRRKKTIGMLTSGLKSVVKWKIIVSSIMLLLLSGTSHVLAVRKGRLMSPSTFTALSGDLHVQIQFNGNEMSSQAEEEHTIGGGPSNEEPLSSSDGLKSRNNTIMSTLVISKIIDEVESPLEKGLTPGPEVTNTSQVVLHRKRKEVVQNIPLFPDPRFNVTQVTVPCQTFLIGGRYEMQVVSNLKSVNRSEVTTTLVPAQDERLHQTLDVRWPSAEMIVSPVRLKTYPKHPVEVTLRFPEVNCNQSGSLALPEFWLELIYCGKDRSCNRNITPTSVLFAEQIRGFPKNKSLHLGCELFGLAGNYAVQLRPMIPAQNVPTTRRLLSVDWSDEFVFNVYARSIFPCDPHTGIGVLYEYPGCILEQGDRVRLYARLRADVASLKPPTSLHYVSEQRVVKSQHSLYFACEHFSEKYVEYCFVYVSQAISGAVADVRMDCVPTLPVSDSDTGGWGPWSEWTPCSTNCLGGTRNRYRFCDSPPPRYGAKFCEGPSVETQKCGKSIADTWDCIYETSGTVITKENSTEVSQEIGPGCRCGCIVHLGSSKPKRIIAGATQSCPGRSFWLIQVDGEESISLALSFLRLPCATQYIKVRDGPSLSSTLLVELNGGGLILKGAGVPVVVDSTGGQLLVEFSAGDGPAGNATQEASPACTGGFMANVQQRLATRSSNSSITLVAATRLSGKTRSVVHKSMSRLRFTLVHLSAMIFASIIIIISSLLGAQYVVRYRKYHLAVARRQDEGSRLHTPRASLSSLQGPPSRAMSTTTLLSEVIYMVKMRPKHHLRHSILRESVDAENLTKETEFKESDSQGMLAKCAEIKELGSSASMVTLRNERSSPARSLDTGSIIGSPSSAEAELAAVHSRSESKDSPSDEPIEPPSCKDSARDSESIISSGMSSLCNSPPMNSKRLSKYSDRYDAVTLKLLSSRLDESLQDASSLLSVTESFRLGRLRTRSVSSSLTNGCYSPAASVVSTATIRTTSNPKESKEKQNRRKLLARPGSEFSLGNQEELEMDYYDYNVINAGSAPGSYLGMDPAYLIWIPPFEEVAEREEDDKTPEPEPDPERDERQPLYEEIRMPKYGHYLSPASNTESSKSTTADNTPSSEERSPPDSGRPSKATSPCDGTERGGRSMPKQPTPFMSRKQRRQSKQQMQSSLSLSAGSLDHEQRRSSKVPIEIAAVHQKVETELEPNDSMTGSYVEKETAVEKSSGDLQEFLSLDDIQFADESGSDYEAVNLKKVPKSELQLSQDDARSKILRRKEPKSKEVAV
Protein: Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) (P04920)
Organism: Homo sapiens (Human)
Function: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).
Subcellular location: [Isoform A]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform B1]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform B2]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Anion exchange transporter
- Solute carrier family 12 member 2
- Solute carrier family 12 member 1-chloride cotransporter 1)
Sequence:
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Protein: GrpE protein homolog, mitochondrial (P38523)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44.
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:16107694}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM44
- Import motor subunit, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM16
- Cytochrome c oxidase subunit 4, mitochondrial
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM50
- Presequence translocated-associated motor subunit PAM17
- 10 kDa heat shock protein, mitochondrial
Sequence:
MRAFSAATVRATTRKSFIPMAPRTPFVTPSFTKNVGSMRRMRFYSDEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGIVKGEEN
Protein: Olfactory receptor 6C6 (A6NF89)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MKNKSMEIEFILLGLTDDPQLQIVIFLFLFLNYTLSLMGNLIIIILTLLDPRLKTPMYFFLRNFSFLEVIFTTVCIPRFLITIVTRDKTISYNNCATQLFFILLPGVTEFYLLAAMSYDRYVAICKPLHYPIIMSSKVCYQLVLSSWVTGFLIIFPPLVMGLKLDFCASKTIDHFMCETSPILQISCTDTHVLELMSFTLAVVTLVVTLVLVILSYTCIIKTILKFSSAQQRNKAFSTCTSHMIVVSMTYGSCIFMYIKPSAKERVTVSKGVALLYTSIAPLLNPFIYTLRNQQVKEVFWDVLQKNLCFSKRPF
Protein: RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (Q8MQY2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU366066}.
Interaction partners:
Sequence:
TTRHWDLNKSFVYKNVSLAMQKIPDEEGATPSRAPGVVAASGAAEGDDGGGGSGAKNSASGNSNNNASGGGIIVLRAALGENEARAVINKWRVREGQFVSAAQILFLYQPVGVDAKDAGKPGGDCAIQRYKSQRAGVVKKRLRKEGELLTKGDAILELSECIHTTVIKDMCADCGADLRQNENGQTSEASVPMVHTMPDLKVTQKLAQKLGHDDTRRLLADRKLVLLVDLDQTVIHTTNDTVPDNIKGIYHFQLYGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDECFNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHTGDINAPPGLSKHELDGEGVDFKEITEKHGDKDKTESSSEVKPEDTDKGDNTVTSTSKDDDVNEESVDVFEIEGDAKDPEVSNASSATEAPKEPRDKLNGKTNAEDIVVIDDSSSGSPDAEKAASDGEDVVVIDDNSKESTKAEVPPTPAEKNEVVASSTTSPDEKRPSADADVATTSKTPSLRAPLEGQKQIEIEDPDDYLLYLEVILRNIHKRFYSIYDETTEIPDLKVIVPKIRSEVLRGKNLVFSGLVPTQMKLEQSRAYFIAKSLGAEVKPNIDKEITHLVAVNAGTYKVNAAKKEPAIKVVNANWLWTCAERWEHVEEKLFPLDRKVRNKGRQPPAHCHSPEHVVNYSERSEISPSSSKQQEEQSGNFRETLNPLLVFTNADIESMNKDYETFFESDSSSDEGPVNFENPPMDKKLLKRKREDDNSNRAHDFFTRSDDIMIGAPNLVEVDISSNEEADDNNEKEDDDDEMPSAKFRRGEDLPSDLELGSESNSEKEPEDEDDGEWNMMGAALEREFLGLEDFDM
Protein: Probable protein phosphatase 2C T23F11.1 (PP2C) (EC 3.1.3.16) (P49596)
Organism: Caenorhabditis elegans
Interaction partners:
- E3 ubiquitin-protein ligase rpm-1
- Sex-determining protein fem-1
- X-linked retinitis pigmentosa GTPase regulator homolog
- mRNA export factor rae-1
- F-box/SPRY domain-containing protein 1
- Serine/threonine-protein phosphatase 4 catalytic subunit 1
- Rho-associated protein kinase let-502
- cGMP-dependent protein kinase interacting domain-containing protein
Sequence:
MGQTLSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQMRVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDTKPAEEQIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDCQMGGLGCDNMTVVLVGLLHGQSPDTLFTKCARPAVFTGVNNEDGDQNQIQQDISRVINNFDGEQRVNAANQEEEEDDNEPAPANFQV
Protein: NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) (P75960)
Organism: Escherichia coli (strain K12)
Function: NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01121}.
Interaction partners:
- Trifunctional NAD biosynthesis/regulator protein NadR
- NH
- NAD kinase
- Nicotinate-nucleotide adenylyltransferase
- Nicotinamidase
- Peptidyl-lysine N-acetyltransferase PatZ
- Purine nucleoside phosphorylase DeoD-type
- NAD
- Soluble pyridine nucleotide transhydrogenase
- NAD-capped RNA hydrolase NudC
Sequence:
MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSIA
Protein: Small ribosomal subunit protein mS26 (37S ribosomal protein PET123, mitochondrial) (P17558)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:2167435}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS43
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS42
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS11m
Sequence:
MGKGAAKYGFKSGVFPTTRSILKSPTTKQTDIINKVKSPKPKGVLGIGYAKGVKHPKGSHRLSPKVNFIDVDNLIAKTVAEPQSIKSSNGSAQKVRLQKAELRRKFLIEAFRKEEARLLHKHEYLQKRTKELEKAKELELEKLNKEKSSDLTIMTLDKMMSQPLLRNRSPEESELLKLKRNYNRSLLNFQAHKKKLNELLNLYHVANEFIVTESQLLKKIDKVFNDETEEFTDAYDVTSNFTQFGNRKLLLSGNTTLQTQINNAIMGSLSNEKFFDISLVDSYLNKDLKNISNKIDSKLNPTSNGAGNNGNNNNTTNL
Protein: Transcription factor Atoh1 (Atonal bHLH transcription factor 1) (Helix-loop-helix protein mATH-1) (mATH1) (Protein atonal homolog 1) (P48985)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:10648228}.
Interaction partners:
- POU domain, class 4, transcription factor 3
- Transcription factor 4
- BarH-like 1 homeobox protein
- Unconventional myosin-VIIa
- Achaete-scute homolog 1
- Zinc finger protein Gfi-1
- Transcription factor E2-alpha
- Achaete-scute homolog 2
- Leucine-rich repeat-containing G-protein coupled receptor 5
- Transcription factor HES-1
Sequence:
MSRLLHAEEWAEVKELGDHHRHPQPHHVPPLTPQPPATLQARDLPVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPELGASEAAAPRDEADSQGELVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPNVGEQPPPPTASCKNDHHHLRTASSYEGGAGASAVAGAQPAPGGGPRPTPPGPCRTRFSGPASSGGYSVQLDALHFPAFEDRALTAMMAQKDLSPSLPGGILQPVQEDNSKTSPRSHRSDGEFSPHSHYSDSDEAS
Protein: DNA helicase (Q7K7J6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MADRANNDDDVDRQPLPIADDADDDVDGIDEMFNNEDEDPEDEEGENLFGDDMERDYREQPELDQYSESGMDDASDVGSLSIRERRRLCRSDSCHVGIVCEHPKSLNHAYDEEDILSSFDRESFG
Protein: F-box only protein 28 (Q9NVF7)
Organism: Homo sapiens (Human)
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MAAAAEERMAEEGGGGQGDGGSSLASGSTQRQPPPPAPQHPQPGSQALPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKATEAIDSLRKSKRLRNRK
Protein: IP05256p (IP05356p) (Q4V6B6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQLATFCCPSSISDSQPLPFKQLFAMPLFNKKFESKPIPVRQGRCNIGHPVATEDLDDFRQISLTLGNKELRFADGIWMHSTRKGDVDDMLRLNKKFRALEEENNMCNLKIEVMLDLLAERDGTK
Protein: Increased DNA methylation 3 (Alpha-crystallin domain-containing protein 51.9) (AtAcd51.9) (Q9SYQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression.
Subcellular location: Nucleus {ECO:0000269|PubMed:25684209}.
Interaction partners:
- Methyl-CpG-binding domain-containing protein 7
- Increased DNA methylation 1
- Increased DNA methylation 2
- Methyl-CpG-binding domain-containing protein 6
- Protein REPRESSOR OF SILENCING 3
- Methyl-CpG-binding domain-containing protein 5
- Protein IDA-LIKE 1
- DEMETER-like protein 3
- Transcriptional activator DEMETER
- DEMETER-like protein 2
Sequence:
MSLYSDGLSSDQYFLVNFIMSNYLGPDVYSDNPRCSSSQRLARGLPPYTLMHIGSSSLTVSQLQNLYYNVLRNAKSSLLLHPDMIYMYLKGYLPLEPSGKFPQFTHFFPTNLHPQKRYSPSHEIVKGIVVIDDPAVGFINKEELQRFRCLSRLDDLKIDRVTSLSPRVNLDESRETEQDCSRNGDATANGVVTNEDYNSSGELQETCKRKEGEDAVASCVISEPERLSGDIPESQGMKQDCSRNGESAFSGIVSDQDYYSFVKLPETCKRKNKEEEAVTGHAVSGTSKTPERFRETYKRRRFKNSSKKATNKNGETLMEREKTDKPIPFSSEMKESDAEPSVVTTGTASKETLGSSVGVVDIGVNKVAYFFQVALPGVRKDYGEFSCEIESDGKVILEGSTTRGEKNIKRHSRVFEMNIRKLCPPGPFKLCFNLPGPVDPRLFSPNFRSDGIFEGVIIRHKNS