wanglab/gogpt-training-data huggingface dataset:
Protein: Tetratricopeptide-like helical domain-containing protein (Q54HV0)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- DEAD/DEAH box helicase
- Superkiller complex protein 8
- DEAD/DEAH box helicase
- HBS1-like protein
- Exosome complex component RRP45
- Exosome complex component CSL4
- Uncharacterized protein
- Small ribosomal subunit protein eS30
- Probable importin-7 homolog
- Uncharacterized helicase DDB_G0278827
Sequence:
MDYIKSKLKETREAIDKKDYKTALENCNEIVQYDDQNFMIHLFLGVSNFNLNNLAAAEKSYIAALKIQNSPVPLRGLLELYNKTNENDKLSNTLKELIPLTTDKQKKKELVFRLIEISYFLKDYKTTIDLISPILFENEKSSDDGENDSESSKIDRIKLLEKFEDANYQYYLNTLKTKIDEKLREKNIPIVDYSKLHVLGAIQHTPEQKQERDKIEFELNKSLINNFNLKVYEELLTKINLNILTNEQMIRIYTHFIQILIGKRRIYSNEENKDEEKQKQLYKEIYENCERMNEMLSTPIYSLENLINLLEEEFNFNDDDDDEDDDQESKNNNELYEKINEISNILTNKYANRGLGWIGLGFYKVFKLKDYSEQSKQLIEKGFSNSGSTESLLGYLALSKWYLKVENHERVRDIVKKSMIVYEQKQRSVGGANYFNNIFIKLQLILVESLSFNCNFELASSLLESLINKFPIHFNYLTFSQSKLNFYSIKDYKKSKELFQLIINNNQNNNQNNNQNKKIIELSKIYLIWIDILLKESKESLIKSKDNLKEIIELNGETANNYLNYYVYGLVLMELNKIENNNNNDNNNDNCSFIIQQFLKSAKLNSNHSDTFAKLGTLYKMIGQKERSKKCYQKSLQLDILNGEAGFELGEIYAESGQTSLVMSLYKEITDFCLSAKQIKRFPINVIKCSWAFYRLAIYQMDNKDIHNSVVSLLNAIKGEPLNESYWRTLAEAYRRQFKYVAALKSLKKAEEILDNENRIATDINFQIATLSKTLGLYDDAINEYDRVLKQLENNVPSLKGKAECLLQLSIEQYKFRNFRQSLIHLELAESSIKIALEKENNFHSLWRLYADISSYFLNLPNNNNNNSNSNNNNNYDYLIEKSKQSSNAYFNCVRIHSNSHSLQDLSIGYYNQYIIFKNYLKQQGKQQQEKNLKVTKEETENLLKSSIKCVVEALNLSPSDPMLWNLLGVVLMDKFPAQSQHALIRSIQLDSSKSEPYNNLTLLYFEYGFIEQSDKSLMIAKNNNIDSVISWSLQGLINEVKSSNKNINNNNNNDNNNNNSTGREDYNYIDNALESSPIGQGLLGYGITSLLEGYSETSYSVLYKYVELNPNSIEGNNSLALVYSHQNDYENSEKYFKSALNLLSNSSNSSKTIIKNNDNDNESKITLNNNNSSCSIGSILFSDKPLNDGIEFSNDEKLKYVKINLSRTQYYLGKFDEALETIKPYITTTQTTEPSLSNSILFELVSLIYCKLNKLNESIDAMKKSISQIPKSLETATIRKQNLLFTLAKIQYTCNNNNNSGKKQQIDTIVKTLEAIITIDKRFYKSWYYLAAIYIDCGKNDLAKNVLIKLQTTVEQLESNSYLLLSKIHLLNNEIEEARKQLQKLIHLFPLEPIGWTSLADLEMKYFINNSNSNSNSENNDPCNLPLSLLNHSLNKKQSQEYSGMGQLSVGPDHKVLQPPTIKELEIIAKANLYDLQSPWTKCLDNAIVIIKRIIHSNPLSTTNNNIQPWVHLQNLLYWRSLYTDNKEDWESTKSCWNVVQYLLTKTTTTTTTITEEFKFQQILIELEFKLALSITSEGDSGTTDDIAEFDKLISNYQKQTNYTNEKKSVLLSLEAKKFLKQGDKVKALSILKDALKLEPNSIPIYHNLCDIYQSNDQLDASLLCLNRSLLVLKQQTTNNNNYNNNNNNGLILTTISKIIRIYCIQKKFKDSLKLLEENLNNNNYLDNPVIKLLKGILIIGSSKLTNNNLKQFTNDMKNALNLLEESSTINSKLSLTNFYSAVVQFNLKNFSLSDILLQKELNLTPSLSLQINSLQEKIKQFTK
Protein: Glycerol-3-phosphate acyltransferase 2, mitochondrial (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase GPAT2) (EC 2.3.1.51) (D3ZI76)
Organism: Rattus norvegicus (Rat)
Function: Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:22905194}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14DK4}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase 3
- 1-acylglycerol-3-phosphate O-acyltransferase 6
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Glycerol-3-phosphate acyltransferase 1, mitochondrial
- glycerol kinase
- glycerol kinase
- Glycerol kinase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
Sequence:
METMLKSNPQMQQRNNHSGQETSLWSSGFGMKMEAITPFLGKYRPFMGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPTSSDASQMIMENTGVQNILLGKVPGAAGEGQAPDLVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHKGQMKMVHKAAQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVLRVALDSRTCSPALRALLRKLGGLFLPPEANLSLDSSEGILARAVVRATVEQLLTSGQPLLIFLEEAPGYPGPRLSALGQAWLGLVVQAVQAGIVPDATLVPVATAYDLVPDAPCNMTHDLAPLGLWTGALAIFRRLCNCWGCNRRVCVRVHLAQPFSLQEYTINARSCWGSRQTLEHLLQPIVLGECSVVPDTEKEQEWTPPTSLLLALKEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVLLRVHQGDLVVVPRPGPGLTHLARLSMELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGIELLSQNELYRQILLLLHLLPQDLLLPQPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQHLSAKLLWKPSGDFTDSESDDFEEPGGRCFRLSQQSRCPDFFLFLCRLLSPILKAFAQAATFLHLGQLPDSEVGYSEKLLQFLQACAQEEGIFECADPNLAISAIWTFKDLGVLQQIPSPTGPQLHLSPTFASRDNQDKLEQFIRQFICS
Protein: Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (G3XCZ6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Beta-ketoacyl-[acyl-carrier-protein] synthase FabY
- Biotin carboxylase
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
- 3-oxoacyl-[acyl-carrier-protein] reductase FabG
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Sequence:
MSASLAFVFPGQGSQSLGMLAELGAQQALVRDTFAEASEALGYDLWALVQNGPEERLNQTDKTQPAILTVSIALWRLWLAEGGARPAFVAGHSLGEYSALVAAESLAFADAVKLVERRGQLMQQAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAVNFNAPGQVVIAGAAAAVERAIEACKARGAKRAVALPVSVPSHCELMRPAAEQFAASVESLQWQAPKISLVQNVSAAVPADLDTLRRDLLAQLYSPVRWVESIQLLAEKGVTELVECGPGKVLAGLNRRCAKGINTHGLDGVEAFAATRAALA
Protein: Protein S100-A6 (Calcyclin) (Lung 10 kDa protein) (S100 calcium-binding protein A6) (P30801)
Organism: Oryctolagus cuniculus (Rabbit)
Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
Subcellular location: Nucleus envelope {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Calcyclin-binding protein
- Annexin A11
- Protein S100-A10
- Advanced glycosylation end product-specific receptor
- Annexin A1
- CS domain-containing protein
- Protein S100
- Protein S100-A12
- E3 ubiquitin-protein ligase
- Protein S100-A13
Sequence:
MASPLDQAIGLLIGIFHKYSGKEGDKHTLSKKELKELIQKELTIGSKLQDAEIVKLMDDLDRNKDQEVNFQEYITFLGALAMIYNEALKG
Protein: Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) (P28738)
Organism: Mus musculus (Mouse)
Function: Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:O60282}. Note=Abundant in distal regions of dendrites. {ECO:0000250|UniProtKB:O60282}.
Interaction partners:
- Kinesin light chain 2
- Kinesin light chain 4
- Kinesin light chain 1
- Kinesin light chain 3
- Kinesin heavy chain isoform 5A
- Kinesin-1 heavy chain
- E3 SUMO-protein ligase RanBP2
- Neurofilament light polypeptide
- Neurofilament medium polypeptide
- Neurofilament heavy polypeptide
Sequence:
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGEETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKALKSVLQHLEMELNRWRNGEAVPEDEQISAKDQKSLEPCDNTPIIDNITPVVDGISAEKEKYDEEITSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEVKKALEQQMESHREAHQKQLSRLRDEIEEKQRIIDEIRDLNQKLQLEQERLSSDYNKLKIEDQEREVKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDSDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAVRGGGGGSSNSTHYQK
Protein: Flagellin (Q56086)
Organism: Salmonella typhi
Subcellular location: Secreted {ECO:0000256|RuleBase:RU362073}. Bacterial flagellum {ECO:0000256|RuleBase:RU362073}.
Interaction partners:
- Flagellar secretion chaperone FliS
- Flagellar hook-associated protein 2
- Flagellar hook-associated protein 1
- Flagellar hook-associated protein 3
- Flagellar hook protein FlgE
- Flagellar basal body rod protein FlgB
- Peptidoglycan hydrolase FlgJ
- RNA polymerase sigma factor FliA
- Flagellar basal-body rod protein FlgC
- Flagellar basal-body rod protein FlgG
Sequence:
MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANGTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKEISSKTLGLDKLNVQDAYTPKETAVTVDKTTYKNGTDPITAQSNTDIQTAIGGGATGVTGADIKFKDGQYYLDVKGGASAGVYKATYDETTKKVNIDTTDKTPLATAEATAIRGTATITHNQIAEVTKEGVDTTTVAAQLAAAGVTGADKDNTSLVKLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYLASDLDKHNFRTGGELKEVNTDKTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR
Protein: Zinc finger protein 106 (Zfp-106) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant) (Zinc finger protein 474) (O88466)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:15833274, ECO:0000269|PubMed:27418600, ECO:0000269|PubMed:28072389, ECO:0000269|PubMed:9507006}. Nucleus speckle {ECO:0000269|PubMed:27418600, ECO:0000269|PubMed:28072389}. Note=Colocalizes with RBM39 in nuclear speckles. Inhibition of RNA synthesis, or overexpression of KNOP1, induces translocation from nuclear speckles to the nucleolus. {ECO:0000269|PubMed:27418600}.
Interaction partners:
- Heat shock 70 kDa protein 4
Sequence:
MVRERKCILCHIVYGSKKEMDEHMRSMLHHRELENLKGRDISHECRVCRVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKEEEEEEYFDKELVQLIQERKEQSRQDEPPSNSQEVNSDDRQPQWRREDRIPYQDRESYSQPPRHHRGPPQRDWKWEKDGFNSTRKNSFPHSLRNSGGPRGSSVWHKGATRGSSTWFLNHSNSGGGWHSNNGMVDWNYNGTGRNSSWHSEGTGGFPSWHMNNSNGNWKSSVRGTNSWNYNGLGDKFQQGRNRNPNYQMEDMTKMWNKKSNKPSKYSQERCKWQRQDRDKAAKYRSPPEGYASDTFPSEGLLEFNFEQRESQTTKQTDTAASKINGKNGTKARDKFRRWTPYPSQKTLDLQSALKEVIGSKSDTLEKPLFNFSLITAGLRKPVDKTSNPPVIKTQKAGPPGSPSHKAISDGTAFCEVARACSITEQSEPHQKSNKIPLLKSPLLPLPTPKSGPHKQNLKNRSKNKETKSFPSGDHSHLLNTSTLEGSHGSSYTSKSLGLCPRVLKENKTVSGTQKEPDEKLNNTSQKAQDTVLQCPKTLQNPLPTTPKRMENDAKESSVEESAKDSLSIESQPHSAGNSAMTSDAENHGIKSEGVASLTTEVVSCSTHTVDKEQGSQIPGTPENLSTSPRNSTVLQKEAEVQVSAATSPHSGLLLDLKTSLEDAQDNNLVKSDGPFETESFEDTSLDTELQKPDLNNQPPGTLLPELSKLGFPASLQRDLSRHISLKSKTGTHLPEPNLNSARRIRNVSGHRKNETEKESGLKPTLRQILNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEVLDLDEEPDLSSLEGFQWEGVSIPSSSGLARKRSLSESSVVMDRAPVYSFFTGEGTGKENEAQQSPSPNTALSAAQSQKTAMYLEQEVAPLTPSVGTGERVGNIPTQRRHSAQLPSGHIMPVMHSARDLHSQERSTPLSERHAQESTGEGNSLSSNASSGHAVSSLADAATDSSCTSGAEQTDGHSIRKKRRATGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLTISLREEELSKSLQCMDNKLLQARAALQTAYVEVQRLLVLKQQITVEMSALRTHRIQILQGLQETYEPPEHPDQAPCSLISREQRNSRSQTSFETALLPAPFFPGFLDPPPSHASLPSPGNPLQITMSTFQAHGTAPDSSVQIKQEPMSPEQEGNMNALPQGCASNVSKELLQTNRVVDDGSSVYPAIPAVIASESTENCQEVSKDLNFSVEQGNSRSKGNSPSCQSPDLPGINRGEETAKGSSGSEACSSSFLRLSFTPETPAEKETQSPADQPEQQAESTLASAETRGSKKKKKLRKKKTLRATHVPENSDTEQDVFTAKPARKVKTAKAAKGAKVTTSQTGQEQGTARDEPDSDSSLEVLEVTNPQLEVVAIDTSESGDEKPDSPSKKDAWIAAEQNPIETSRSGCDEVSSTSELGTRYKDGVPVSVAETQTVISIKASKHSSEISSEPGDDEEPTEGSFEGHQAAVNAIQIFGNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHTSGKSSVLYTGSSDHTIRCYNIKTRECMEQLQLEDRVLCLHNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSVIYTGCYDGSIQAVRLNLMQNYRCWWYGCTLIFGVVDHLKQHLLTDHTNPNFQTLKCRWRNCDAFFTARKGSKQDVAGHIERHAEDDSKIDS
Protein: Calpain, putative (Q57WJ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGCGGSKPRPQPPQMPPPPPPPVVAPPPPPPPPPPEPVAPPTPPPKSPTVQSEESVVEEVEEVPLTPRAARLQNVIAAKQSTFMYNKCTVTGEVTPFFPPKGRCFRIIDEEGRWFFYNDTMNYEMCVQAFFSPDSDVKHCGTTTIKSIRNGLTVISAFVYPLETLEFLSGSVELGAMYVYAQQLSKRYYSHLRVFSVDGKKEMETVMTLPWEEVDDEELLKLCSDSFMRYADVKFLPSTGMFSRLDIDGRFIQPVEVRRPSEFAQCDEENIDAVRGVVLSSCVEAGTLGDSWFVSALSLLATDEERVKAMFASTTPAEKQMGAYRVLLNKDGWWKNILVDDFLPTVGGVPCYARCIDDPGELWPSLLQKAYAKLYGSYASITGGDTLLALQNFTGAPVYRFDKAWRDAATDEEKKNALIQKIMGYVEAHNPVILSVPTGKEAKTAVANGLGEGYSYALLSVHNFPEENITLLKMFNPWEPAMPWSGQWREGSDKWTEHSEIQSSCEPCFEAHDGIFFIEWSEAVEVFNGCGVLYLDEKPVYDYRVAGEFDNEQPNLALMIRAKETVEVMLTLSQRDKRGLPIESPDAKLSPVLLCVSRAERKRQVVYQCTSSDPETPAEGFNFVVGRDLAMKCTFEAREAPYFVIPRIHRRGTCEGRRRGFVIGIRSSTPLDEKLEIHFTTLEPTCRVLHNCITFTANRMPGAVREWQIKTPDAEPATYRGWGLSPAEEFHEDDEGALTREYVVSQPEESPTPQSEAHVSEEEAKPEEECQQPSDEKPHELTEEPEAEAAAPEPMGEGDVVAEAQPELAVEELSEGDVEAREAPAPPEEPQVTAEPESPQQSAEPEPEAAPPAPTDDGSASESSDDGLGRFAADRIGAFALSDDSDTD
Protein: Polycomb protein Suz12 (Suppressor of zeste 12 protein homolog) (Q80U70)
Organism: Mus musculus (Mouse)
Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
Subcellular location: Nucleus {ECO:0000269|PubMed:16415857}. Chromosome {ECO:0000269|PubMed:16415857}. Note=Localizes to the inactive X chromosome in trophoblast stem cells.
Interaction partners:
- Histone-lysine N-methyltransferase EZH2
- Zinc finger protein AEBP2
- Histone-binding protein RBBP4
- Polycomb protein EED
- Histone-binding protein RBBP7
- Protein Jumonji
- E3 ubiquitin-protein ligase RING2
- Histone-lysine N-methyltransferase EZH1
- Transcriptional repressor protein YY1
- Metal-response element-binding transcription factor 2
Sequence:
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAASGGKSGGGGCGGGGSYSASSSSAAAAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTSIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESATPSNEEIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL
Protein: D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (P9WNX3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Interaction partners:
- Phosphoserine aminotransferase
- 3-isopropylmalate dehydrogenase
- Possible D-3-phosphoglycerate dehydrogenase SerA2
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
- Probable sulfatase
- Alcohol dehydrogenase B
- Adenosylhomocysteinase
- S-adenosyl-L-methionine-dependent methyltransferase
- S-adenosyl-L-methionine-dependent methyltransferase
- Phosphoserine phosphatase SerB1
Sequence:
MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Protein: Myb-related protein A (A-Myb) (Myb-like protein 1) (P51960)
Organism: Mus musculus (Mouse)
Function: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30.
Subcellular location: Nucleus {ECO:0000269|PubMed:21750041}.
Interaction partners:
- Protein lin-9 homolog
Sequence:
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSPTKFLAVEANAVLSSLQTIPEFPRTLELIESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSRNGGDSEAIPLTSPNVVKFSTPPTISRKKKRIRVGQSAGSELGSASLSEVGNRRIKHTPVKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL
Protein: Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) (Q14186)
Organism: Homo sapiens (Human)
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q08639}. Cytoplasm {ECO:0000250|UniProtKB:Q08639}. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000250|UniProtKB:Q08639}.
Interaction partners:
- Retinoblastoma-associated protein
- Transcription factor E2F4
- Transcription factor E2F5
- Transcription factor E2F6
- Transcription factor E2F1
- Transcription factor E2F3
- Retinoblastoma-like protein 1
- Transcription factor E2F2
- Retinoblastoma-like protein 2
- Polycomb group RING finger protein 6
Sequence:
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASDLTNGADGMLATSSNGSQYSGSRVETPVSYVGEDDEEDDDFNENDEDD
Protein: Leucine-rich repeat protein (LRRP) (Q384D3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHSKASSVYIEACKRDHAECALEFVYALDNNESEVCLSNRTVHLNDIDVKCIAETLQTTRHTVRALIMEGNAFGLNGLQALLEAIEVNPGIVRELRLGRNKLKDQAAVVIGHVLSRSGCGLRVLDLSENEITKLGVIPIAAALSNGLCDIVELSFHNNKIEADAATYLGQAIRQAGKLKHLHLGYNTIRDEGAVQLAKCIPVTVSLSTLDLTANRIGASGGRELARALMTTTCNIQRLNLRHNLFDSETIEMYGEVIARNTSLIQLFLGFMNPAPESAAVVLSSLRKNRTMLLLDIYGWKLPPDEAWTIINSIQKSNTILMALVTDACQSIAKQIDQGNEERDYQGQYPIYVGPDDRDAYMATKSLRRASRAQSRRQSRSNSRIASSRNATPSALTTPVNRRQHERTSSRKNSENQSRQSASNSQIGREPNSQRDQSYVVPPHTTSTDRSQEKHRDIQRRSSRGLDPSASYDARVNQGTNDASPMSVFELAQSNKALESLVDELRREIARQKENYRALEARVTALEMQGRCPTVPQHRTSGVPSREETVDLRRLGRPPSTTNDDASHPAKSIMSTPCNSERAYDLPSPGDLRRTNTQSDFAPPNRSASAVELYSLRRRRSNALITTGHDLNQSRTSEVESRGAPAEYPQLNSLRGDPSFPPAEPVQLPMENKPLEVVLQTSAKPREETTVYLGPGPCKDKDPPRRKGSVQSIY
Protein: Glucan endo-1,3-beta-glucosidase 1 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase 1) ((1->3)-beta-glucanase 1) (Beta-1,3-endoglucanase 1) (Beta-1,3-glucanase 1) (O65399)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Potassium transporter
- Glycosyl hydrolase family protein
- alpha-D-xyloside xylohydrolase
- Xyloglucan endotransglucosylase/hydrolase protein 2
- Probable xyloglucan endotransglucosylase/hydrolase protein 6
Sequence:
MAFTSMVSTVPVLFFFFTLLLISANSSSLSHNIKVQEQDKDPFVGFNIGTDVSNLLSPTELVKFLQAQKVNHVRLYDADPELLKALAKTKVRVIISVPNNQLLAIGSSNSTAASWIGRNVVAYYPETLITAISVGDEVLTTVPSSAPLLLPAIESLYNALVASNLHTQIKVSTPHAASIMLDTFPPSQAYFNQTWHSIMVPLLQFLSKTGSPLMMNLYPYYVYMQNKGVVPLDNCLFEPLTPSKEMVDPNTLLHYTNVLDAMVDAAYVSMKNLNVSDVAVLVTESGWPSKGDSKEPYATIDNADTYNSNLIKHVFDRTGTPLHPEMTSSVYIYELFNEDLRAPPVSEASWGLFYGNSTPVYLLHVSGSGTFLANDTTNQTYCIAMDGVDAKTLQAALDWACGPGRSNCSEIQPGESCYQPNNVKGHASFAFNSYYQKEGRASGSCDFKGVAMITTTDPSHGSCIFPGSKKVGNRTQTVVNSTEVAAGEATSRSLSRGFCVTIMILVTFSIL
Protein: Transcriptional activator Myb (Proto-oncogene c-Myb) (P01103)
Organism: Gallus gallus (Chicken)
Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Subcellular location: Nucleus.
Interaction partners:
- Runt-related transcription factor
- DIRP domain-containing protein.
- Transforming protein p68/c-ets-1
- Rhombotin-2
- Myc proto-oncogene protein
- CCAAT/enhancer-binding protein beta
Sequence:
MARRPRHSIYSSDDDEEDVEMYDHDYDGLLPKAGKRHLGKTRWTREEDEKLKKLVEQNGTEDWKVIASFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKAGLPSATTGFQKSSHLMAFAHNPPAGPLPGAGQAPLGSDYPYYHIAEPQNVPGQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPVDHGCLPEESASPARCMIVHQSNILDNVKNLLEFAETLQLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHRDQPFKTQKENHVFRTPAIKRSILESSPRTPTPFKNALAAQEIKYGPLKMLPQTPTHLVEDLQDVIKQESEESAIVAGLHESGPPLLKKIKQEVESPTDKAGNFFCSNHWEGENLNTQLFTHASTMEDVPNLLTSSILKMPVSEEEGSFHKAFAVPRNRPLASPMQHLNNAWESASCGKTEDQMALTDQARKYMAAFPTRTLVM