wanglab/gogpt-training-data huggingface dataset:
Protein: Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) (Q96JH7)
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.
Subcellular location: Nucleus {ECO:0000269|PubMed:32649882}. Cytoplasm {ECO:0000269|PubMed:32649882}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8CF97}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8CF97}. Note=Associated with Golgi stacks and endoplasmic reticulum (By similarity). Displays cytoplasmic to nuclear translocation in response to DNA-protein cross-links (DPCs)-inducing agents (PubMed:32649882). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:32649882}.
Interaction partners:
- NSFL1 cofactor p47
- Transitional endoplasmic reticulum ATPase
- Nuclear protein localization protein 4 homolog
- Ubiquitin recognition factor in ER-associated degradation protein 1
- UBX domain-containing protein 7
- UBX domain-containing protein 2A
- UBX domain-containing protein 2B
- Syntaxin-5
- FAS-associated factor 2
- Cyclin-dependent kinase 1
Sequence:
MSQPPPPPPPLPPPPPPPEAPQTPSSLASAAASGGLLKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGKDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRTDKNYSFPLNNLVCSYDSVKDVLVPDYGMSNLTACNWCHGTSVRKVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWDGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDSSLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRVGDVQGQESESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTVKQEDIAVTGKLSSKELQEQAEKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYSIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASGNPHLDPRARETSVVRKHNTGTDFSNSSTKTEPSVFTASSSNSELIRIAPGVVTMRDGRQLDPDLVEAQRKKLQEMVSSIQASMDRHLRDQSTEQSPSDLPQRKTEVVSSSAKSGSLQTGLPESFPLTGGTENLNTETTDGCVADALGAAFATRSKAQRGNSVEELEEMDSQDAEMTNTTEPMDHS
Protein: Selenoprotein W (SelW) (P63300)
Organism: Mus musculus (Mouse)
Function: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.
Subcellular location: Cytoplasm.
Interaction partners:
- Thioredoxin reductase-like selenoprotein T
- Selenoprotein K
- Selenoprotein H
- Selenoprotein F
- Selenoprotein S
- Protein adenylyltransferase SelO, mitochondrial
- Selenoprotein N
- Selenide, water dikinase 2
- Selenoprotein P
- Methionine-R-sulfoxide reductase B1
Sequence:
MALAVRVVYCGAUGYKPKYLQLKEKLEHEFPGCLDICGEGTPQVTGFFEVTVAGKLVHSKKRGDGYVDTESKFRKLVTAIKAALAQCQ
Protein: Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein Tcs3) (tRNA threonylcarbamoyladenosine biosynthesis protein Tcs3) (Q9VV41)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03180}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03180}.
Interaction partners:
- L antigen family member 3
- non-specific serine/threonine protein kinase
- LD10347p
- tRNA
- Signal recognition particle 54 kDa protein
- 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
- Probable GDP-L-fucose synthase
- Elongation factor G, mitochondrial
Sequence:
MVCALGIEGSANKIGIGIIRDGKVLANVRRTYITPPGEGFLPKETAKHHREAILGLVESSLKEAQLKSSDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIEMGRLITGAQNPTVLYVSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFARIIKLSNDPSPGYNIEQLAKSSNRYIKLPYVVKGMDVSFSGILSYIEDLAEPGKRQNKRKKPQEEEVNNYSQADLCYSLQETIFAMLVEITERAMAHCGSNEVLIVGGVGCNERLQEMMRIMCEERGGKLFATDERYCIDNGLMIAHAGAEMFRSGTRMPFEESYVTQRFRTDEVLVSWRDD
Protein: THAP domain-containing protein 3 (Q8WTV1)
Organism: Homo sapiens (Human)
Function: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.
Interaction partners:
- THAP domain-containing protein 11
- 52 kDa repressor of the inhibitor of the protein kinase
Sequence:
MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFRPECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQVSPRRPQATEAVGRPTGPAGLRRTPNKQPSDHSYALLDLDSLKKKLFLTLKENEKLRKRLQAQRLVMRRMSSRLRACKGHQGLQARLGPEQQS
Protein: Protein nullo (P32845)
Organism: Drosophila melanogaster (Fruit fly)
Function: Actin-myosin network stability during cellularization. Might be involved in increasing actin-actin interactions or membrane-to-cytoskeleton attachments. nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
Interaction partners:
- Protein bottleneck
- Serendipity locus protein alpha
- Slow as molasses, isoform B
- RE73396p
Sequence:
MGSTHSAEKVKSVEDSTSPANPGIFCTPLPGFISNIQRLVLRKLSISARKQKRLNKRSKHLLRPMPRCSSFGSCGTLLTPTKKSASNIADRRYAQWKCSFEHLAQKQPRLHDISEAMTGQTTPRGFPSHTDPKRCLMVMDSSSPESPLYDMVGGQKVRRRLSLRSHALVRRPSARQKAEQAKLDAQFQRDLRDLEDYYGGFHFAQRRERLVKV
Protein: Mutator family transposase (O06367)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Alpha-pyrone synthesis polyketide synthase-like Pks18
- Conserved protein
Sequence:
MALPQSALSELLDAFRTGDGVDLIRDAVRLVLQELSELEATERIGAARYERSDTRVTDRNGARSRVLSTQAGDVELRIPKLRKGSFFPAILEPRRRIDQALYAVVMEAYVHGISTRAVDDLVEAMGVETGISKSEVSRICAGLDEIVGAFRTRTLGHIEFPYVYLDATYLNVRNGTGQVVSMAVIVASGIAADGSREILGLDVGDSEDETFWRGFLTSLKGRGLGGVRLVISDQHAGLVKALKRCFQGAGHQRCRVHFARNLLAHVPKDKADMVASMFRMIFSAPDAEAVHATWEGVRDRLAASFPKIGPLMDDARAEVLAFTAFPKAHWQKIWSTNPLERINKEIKRRSRVVGIFPNPAAVIRLVGAVLADMHDEWQASERRYLSEASMALLYPDSDNAVVAAISGGQ
Protein: AT3g56130/F18O21_90 (Biotin/lipoyl attachment domain-containing protein) (Q93W03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASSAALGSLHQTLGSAINSQSEVHSLSGNWSASGNSCVPRWRLSNRNSNYRLVLRAKAAKSSTTTISDGSSDASVSDGKKTVRRITFPKEVEALVHEMCDETEVAVLQLKVGDFEMNLKRKIGAATNPIPVADISPTVAPPIPSEPMNKSASSAPSPSQAKPSSEKVSPFKNTSYGKPAKLAALEASGSTNYVLVTSPAVGKFQRSRTVKGKKQSPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAVLPSFHDINIQ
Protein: Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Q92747)
Organism: Homo sapiens (Human)
Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8978670}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
Interaction partners:
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 1B
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
Sequence:
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM
Protein: Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) (Q9UH73)
Organism: Homo sapiens (Human)
Function: Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Paired box protein Pax-5
- Zinc finger protein 423
- Methylcytosine dioxygenase TET2
- Transcription factor E2-alpha
- LIM/homeobox protein Lhx2
- DNA-binding protein Ikaros
- Zinc finger protein Aiolos
- CCAAT/enhancer-binding protein alpha
- Protein O-mannosyl-transferase TMTC1
- CCAAT/enhancer-binding protein beta
Sequence:
MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM
Protein: V-type proton ATPase subunit H (A0A8I6AIG1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLNKKAGRISVEQTRGQMISAEDCEFIQRFEMKRCSEEKQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTMVDDMLQENHQRVSIFFDYAKRSKSTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTISASDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS
Protein: T cell leukemia homeobox 2 (T-cell leukemia homeobox protein 2 isoform X1) (A0A2R8QHC0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MEHTGIEEVNQTHQQHETISFGIDQILNGSDQSSSCMLPSRTGDPDYALTPNVYNGYNSMYPACSMAAGLAGSYNVNMNMNVSMNMNVNVNSGNAGGVIRVPAHRPMPPAPHQPTAGHPPSIAAGIPTMPTVPSMGSPHSFTFPWMESSRRFAKDRLTAALSPFSVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQQEAFQKTLSQPLQQDPLCLHNSSLYALQNLQPWAEDNKVTSVTSVASVV
Protein: ALMS1 centrosome and basal body-associated protein (Centrosome-associated protein ALMS1 isoform X1) (F1QF92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
- Bardet-Biedl syndrome 1.
- Serine/threonine-protein kinase PLK
- Bardet-Biedl syndrome 7 protein homolog
Sequence:
MDSVGDAADVNNTPAETPCQKHGQNIHDSEVDRPYAGPANDGRPFNNLQDSSIQPMMNRFEILQLEFQDSQLSPALPLLPCLDKSNFLSNSSVFQETDLEFVPLRGIPDFSVIPERCSSISDEAVTVDSQLQTSIHDQATISEHPLEVPTALSEGENSSCSLSQHSLSHNDHSRGLGNQSSVLYSNEYKINRHMEGEEQTAAQRLSEGMHARPLLELREEDISVAVSNSSAISSPSEPGSNHQNTQKIQTSPSNLQADREQPQGGSLSLTSSFQKATVSTARSDVSNITFRDSQMDTHQTADHLHDQLLTASGSLSAPASRLHGGNKSSDSAQSFTIAGEDLIHVPGLQRALLSSGGRLIGADGSFLSSQPVFQSTPAVPPTRPLPALTKPSLIHSKQKAVASAATLPQSNQSRTGLMPLLDLSDQHSSSMYSQTTSSKPPKTEQTVSHAHSVSNEHISPAVLNPTAADTSRSDTQLFYSSTEKKDQVSHLALGRVQSLPSLSYLQKVDAWKANQSSSRSFCDNLALQGVDGVSLKKKAQDVGSDIFNQMDSRDKHQALCMNASSQSIQQLSSSHSGSVSPRRVDEAGASVCKGQASDSPVIRSQSHSSLSSVVTSIQRDTGTLSKQAPLTQSKDVPATNQSSLISGGSNEGMNTSAAHMDTNAIKMSPFLSLGRFSDVSSSVNLSSTLSSSQGSYHGEQSMRASVGAASSVVSLEVDNYAPYWTSRPTSPPHTREFNIEDRIPLYLLNLGIDQSPSTILNPFTRRGPIREPEFSPTDLCTIKGSIGTPTKSTQPSEVDSLQKETFSSSSQHSTESSASVSHHLSVHELSQPATDSSVKVILTQADAAQLQSTSHPSTTLQQSDAAESERSFSLPVPESGPREVVKADDDSLVGSGTLHEIRRLLGRAESLVSGRSSLTSSPGSHRLSESDTSLVSLGRNARGYHTDTSLSAGGNLSLLLTRSSSDSALKGSLSSSQGPQHIDLTTVKPAALSLSREESLKARDLRVTPRRAEPEGCSAADPDKGKPTTTTSGTQINLPSIAVSVPQNEEDTSEDAPIGSSENSLSHVSAEAESLSDSSSESSLAARVAKLLQSESPVSMVTSRPSTADPEDSRAREWILMKVSGRRCESLELNTEDRKRIEEIKRELLLNTKYTKWSSDSEGSAQSSIGLESQQTKGYVGLRNMENRLSDQLQKAPSNPLSTVQDLEAKVHEIALREGFSTKPFTSITISTTRRTPSPQSPPHSPVTGTLKITNVGSANETPAGTKDSDREKETEGQHIDEKKTTEDKQENTITDKAQRMSHIDYNVTSSTFNNKSHLSHIHVTLSPKPKNQIRFEKSTQNISQDVALQRPIVPSVADPQLEPMHRISTLNHVSSYEYRERVQGQNTGRVSARFPARHTQSSAPSNRLDMKSRTLSGQTAYGTAAVPTLLPYKPHGSSELFYMPQVDPELSPGRSDTTVESSHPDSDDAVPPHFNKDILGSREQEDNTITPKHKEGIYSKRTNMNKVSSGDCPPKSASTFVSTAPEVSKKNMETVGIDAEYNDKEDHFVPLNMEADNSMDHVHFHNSTTQEPKIPREPHYSSSQPNRRPYRGNKKGKDRTPHDVSLEITSSLDQLWRRFNEKWSTEESRSINDGETSLLDRLERLSRLIHNTTPTDHSVQQSSDSGNGEYDRMRNQEEEEQRERVQLKAPPKHAWVQDEGQGKVHLCPAERDESVETSSSVSTVDTERLQRAFGAHRVAREGMKSDGSLLRLYNSINAKKTSRRKPSTKDAAVSVTTDNTDDSTVSAGSLSSSSTSFHHSQRGVYSLKTKKSKVKLVSKSVQAGDLEIVINGTRKHTRDVGTVFPSPGAFKNVSSSNKFGSGLQNGIPIPTASTAKPIQTALKRDSSNKSVRTRYPHGVSWFVSADELKFDGRKENQPQNESEPSISQAWFEPYSRTRPWRESSREPLRERQNQQEQERQTETRTAMETDISDKTSALVRLSLQEALELHRPEFVSRSRERMKRLGLLVEERRLQAIFNREREELFNFPAPSRPLRAAPVPRKRVVPRKEMVQRSREKYAKLPEVQKRREEEKRRAEYRSYRLTAQLFNKKVTNRVLGRRAPWQ
Protein: Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog) (Q9DB25)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y673}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dol-P-Man:Man
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Dolichol-phosphate mannosyltransferase subunit 3
- Dol-P-Man:Man
- Dolichyldiphosphatase 1
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 1
- Dolichol kinase
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
Sequence:
MATLLLQLLGLGVALAAAALILVSIVAFITATKMPPCYQHEEEKFFLNAKGQKEALPSIWDSPTKQLSVVVPSYNEEKRLPVMMDEALNYLEKRQKHDCTFTYEVIVVDDGSEDQTSKVALKYCQKYGSDKVRVITLVRNRGKGGAVRMGVFSSRGEKILMADADGATKFPDVEKLEKGLSDLQPWPEQMAIACGSRAHLEKESIAQRSYFRTFLMYGFHFLVWFLCVKGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTEIEGSKLVPFWSWLQMGKDLLFIRLRYLTGAWRLKQTRKAS
Protein: Uncharacterized protein (Q4GYA7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGLPGSGTQLHNYFDLIVNSDPRVAFDILHPAVMNAIEKMERSQRRSHHADANDDDEEEGEGEGEGEDGDEYGEGGGDCLMGAAAVSAKTNEEATAIVVNNDVRACFVIPTHQSVLDTRHVHQPDLAGMEAFNSQKNHHLAHQVLGPALMHEVQKFGLQKRRRNEVEGVEEEDQSTE
Protein: Ankyrin repeat and SAM domain-containing protein 6 (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) (Q6GQX6)
Organism: Mus musculus (Mouse)
Function: Required for renal function.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:23793029}. Cytoplasm {ECO:0000250|UniProtKB:P0C0T2}. Note=Localizes to the proximal region of the primary cilium in the presence of INVS. {ECO:0000269|PubMed:23793029}.
Interaction partners:
- Serine/threonine-protein kinase Nek8
- Nephrocystin-3
- Ankyrin repeat and SAM domain-containing protein 3
- Inversin
- Serine/threonine-protein kinase Nek7
- Nephrocystin-1
Sequence:
MGEGALAPGLQLLLRACEQGDTDTARRLLEPGADPVAGPEAGAEPAGPEAVRAAEAGAPVPVDCSDEAGNSALQLAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARCGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAIVDHHTPSGESPATGGSGDELLGITALMAAVQHGHEAVVRLLMEWGADPNHTARTVGWSPLMLAALLGKLNVAQQLVEKGANPDHLSVLEKTAFEVALDRKYRDLAEYLDPLTTVRPKTDEEKRRPDIFYALKMGNFQLVKEIADEDPNHVNLVNGDGATPLMLAAVTGHLPLVQLLVEKHADMDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVALRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDRGRPSHRPPLPHSKARQPWSIPVLPDDKGGLKSWWSRMSNRFRKLKLMQTLPRGLAANQPLPFSDEPELALDSTMRAPPQDRTSHLGPPEAAHATKDSGPGNPRREKGDVLLTTMLRNGAPFPRLPSDKLKAVIPPFLPPSSFELWSSDRSHTCHNGKADPTKTALPPRASRAHPVGCVGTDGATSRPVKFPSISRSPASPASSGSFNHSPHSSGGASGIGGMSRLGGELHSRSGGSVDSVLSQIAAQRKKAAGLCEQKPRQQSSPVGPATSSSPPELPASLPSSGSGSSSGPSSSKKLDPSKRPPSGTSATSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLQELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFESSASNTRAPGNGPSMAGWTRPEETVSSRR
Protein: General transcriptional corepressor ssn6 (O60184)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as component of the ssn6-tup corepressor complexes, which are involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex (By similarity).
Subcellular location: Cytoplasm. Nucleus. Note=Nuclear dots.
Interaction partners:
- Transcriptional repressor tup12
- Transcriptional repressor tup11
- Transcription factor atf1
- Transcription factor pcr1
- Large ribosomal subunit protein uL3A
- Large ribosomal subunit protein uL3B
Sequence:
MPQSQVATASPSQNAQPNHGMGSKVLSSDPNASLPPQTAYYASPLHANSVSLPPSHLPRSTLHPLLSQQQQPAQQSPSLGPAQQNIQQPPSVSIASQPHYAEAIVPIQQVLQPQQYRQLPPNMVAATNAPQQHPQLQRMMPILSSNQPIQQLPLPNQASPYIPVPLQQQQQSQPQQQPQQQQHQQPQQPQPPQQPLQQQQQQRQLHSGIQQPVSTIVSQNGTYYSIPAVNHPMAGQPIAIAPVPAPNQAALPPIPPQALPANGTPNTLASPVTLPAANSAVQNAQPVPMTSSPAMAVVPQNKTAATSTLAAQQGANVLPPNAPESVRHLISLNEETWIQIGRLAELFDDQDKALSAYESALRQNPYSIPAMLQIATILRNREQFPLAIEYYQTILDCDPKQGEIWSALGHCYLMQDDLSRAYSAYRQALYHLKDPKDPKLWYGIGILYDRYGSHEHAEEAFMQCLRMDPNFEKVNEIYFRLGIIYKQQHKFAQSLELFRHILDNPPKPLTVLDIYFQIGHVYEQRKEYKLAKEAYERVLAETPNHAKVLQQLGWLCHQQSSSFTNQDLAIQYLTKSLEADDTDAQSWYLIGRCYVAQQKYNKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYQDALDAYSRAIRLNPYISEVWYDLGTLYESCHNQISDALDAYQRAAELDPTNPHIKARLQLLRGPNNEQHKIVNAPPSNVPNVQTAKYINQPGVPYSNVPVAQLSGNWQPPHLPQAQLPSATGQSGVVQQPYQTQPSVTNNNVATQPVIASTVPVQTAAPSSQTAVPQTIHQSNAFTPRGKHASGSRNSISSTKSPQHKLSDQPRSRNNSISNVSHRERSNSVSSKSRETRTSASNESDPKKSTQRDSSKKLENSTVVSGSPSSSSKSDAAKSIKPQKPEPALKPVEGTADPKSTKRNHQETEKTADTDVSSTEPVKRQKTADVNDDVGEEEVKQSVSEQVDSAQLTSEPKSESLPKSPEEKSDDTSNDVTTENTNDINGDSNMDNVATVDKSTDAVDTSTATVAATTTTAEEELPQKESQERSSPSPENQDSTPLAPKSVSPKQAARTLDIDENYDDDEGEKETVSV
Protein: Probable serine/threonine-protein kinase WNK5 (AtWNK5) (EC 2.7.11.1) (Protein kinase with no lysine 5) (Q9SCU5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates flowering time by modulating the photoperiod pathway.
Interaction partners:
- Transcription factor bHLH157
Sequence:
MYMEISSASDDSIAYVETDPSGRYGRFREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATDERDLAPLFRLPQQLAIQNLAANGTVVEHLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDGHMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVPNWRANDSSIRHESFGHEDDEDNGDTEGRTRLFSSASSSHDSPVAVRENNDDSSNDVIPDMDDGNRSSNRLLNSSTYHYSPAIDDDQNQQQRRRVRLQQKMRSLVDTRTQVLHRSLMELINKRRGRGFDPNTNELQPQPSSTDFIRRC
Protein: Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) (Q90593)
Organism: Gallus gallus (Chicken)
Function: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). May also play a role in apoptosis and cell proliferation (By similarity).
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P11021}. Melanosome {ECO:0000250|UniProtKB:P11021}. Cytoplasm {ECO:0000250|UniProtKB:P20029}. Cell surface. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localizes to the cell surface in epithelial cells; high levels of free iron promotes cell surface localization (By similarity). {ECO:0000250|UniProtKB:P11021}.
Interaction partners:
- Hypoxia up-regulated protein 1
- Activating transcription factor 6.
- Endoplasmin
- Protein disulfide-isomerase A3
- DnaJ heat shock protein family
- SEC63 homolog, protein translocation regulator.
- Uncharacterized protein.
- Mesencephalic astrocyte derived neurotrophic factor.
- BZIP domain-containing protein.
- SIL1 nucleotide exchange factor.
Sequence:
MRHLLLALLLLGGARADDEEKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKYLPFKVVEKKAKPHIQVDVGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDARNELESYAYSLKNQIGDKEKLGGKLSSEDKETIEKAVEEKIEWLESHQDADIEDFKSKKKELEEVVQPIVSKLYGSAGPPPTGEEEAAEKDEL
Protein: AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) (Q8IVW6)
Organism: Homo sapiens (Human)
Function: Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:10446990, ECO:0000269|PubMed:17400556}.
Interaction partners:
- AT-rich interactive domain-containing protein 3A
- Transcription factor SOX-2
Sequence:
MEPLQQQQQQQQQQQKQPHLAPLQMDAREKQGQQMREAQFLYAQKLVTQPTLLSATAGRPSGSTPLGPLARVPPTAAVAQVFERGNMNSEPEEEDGGLEDEDGDDEVAEVAEKETQAASKYFHVQKVARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKDASKASPSVSTAGQPNWNLDEQLKQNGGLAWSDDADGGRGREISRDFAKLYELDGDPERKEFLDDLFVFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLVEIINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQAAIDGNRREGRRPSYSSSLFGYSPAAATAAAAAGAPALLSPPKIRFPILGLGSSSGTNTSSPRISPATTLRKGDGAPVTTVPVPNRLAVPVTLASQQAGTRTAALEQLRERLESGEPAEKKASRLSEEEQRLVQQAFQRNFFSMARQLPMKIRINGRAEDRAEASAAALNLTTSSIGSINMSVDIDGTTYAGVLFAQKPVVHLITGSAPQSLGSSASSSSSSHCSPSPTSSRGTPSAEPSTSWSL