wanglab/gogpt-training-data huggingface dataset:
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (C1C5A0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
Sequence:
MIVINASDTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFERTMERKMYSTRSELDFV
Protein: Cytochrome c-552 (Cytocrome c subunit of the nitrate reductase) (Q934F6)
Organism: Thermus thermophilus
Interaction partners:
Sequence:
MARRLLPLALAFLLGLSLAQDGKALYGTHCASCHGAEGQGIPGAIPPLAGNPRVQDEAYVVRAVREGLSGPLEVGGVTYDGVMPPLPQVSEAEARAIAQYLKGLGGAPAQAAPAPQVQGDPALGRALYLGQKALKNGGAPCQACHTVAGVGFFGGGALGKDLTDAAKRLGGEAGLAALLENPAFPVMREAYKGKPLTKEEATALAAFLVQVSQEAPRPSSLYLGRFLVAGLVVLALLLLYQAVLWQLRPRSLAERIRAQLRR
Protein: GPI transamidase component Tta2 (Q38B93)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLGNKVVSSPLVAALVALAVRLLAHNFSHHIHLPYHFGITTSKTGSEIWKEAVFWKQQFGVVPAFLTTVGPWFMEYIPPASSDAYVIFLCLCDALTVYIVSRWPSAKPQLTYALFVLNPIMALLPMLESLAPLEHVLLAVILECCRKRRIHPWLIFAARLLAPLLGFHFIAIIVALWYPVGTPCPKIALVGVALCTACIGGCGMLYLRWWGEHVERTSLYSPPDNGVMWYVRLLIMAAFHRSMEVGQIELPAVLTLIFSTGVPCEKEAAAETMKDGGAIPGDRRLLVTLLAICFSKLFCEHVILADYMITVFFLYSLLEVKGRGGFKSMLDRVRGLNIFLPICTLLLGVPLQYAFYTGWVMWDMANPNWVFFPQVAFVTGGGLFLLAFVNSLVDAMKEECVAGITKEKQA
Protein: Crossover junction endonuclease MUS81 (EC 3.1.22.-) (Q57TT9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369042}.
Interaction partners:
- asparagine--tRNA ligase
- DNA repair protein, putative
- RecQ mediated genome instability protein 1 OB-fold domain-containing protein
- DNA repair protein RAD51 homolog
- Alpha-1,3/1,6-mannosyltransferase ALG2
- DNA repair protein, putative
- Exonuclease, putative
- DNA 3'-5' helicase
- DNA 3'-5' helicase
- DNA topoisomerase
Sequence:
MPNSHNERIASYIERRWPQRFPEFCAALRRYPLPISSGAAGTQLHGSCPEAVRATEAFCAMLAPRHGREVLGDDNSTNDEMLARDGEVSVAALRRSVSFPFSPFRCFKMQRTEGGPPLLSGQPAVWSGNSDWHFDQLHNSRGEAGTSLMHSSTTGCQSGEPLPEEKLSWRELRDRCLSKGLLGSGTKVHLIARLRKHGASKLAETSPKPRYVPDSQAEVLSHLREDSERCSRSMSSAGHTSTVSDMIRHGQRLRTLFRSPNTDIAPTTSLAEGGSEPQGRLLGTPKEFVASQQRERKLVHSTPSMPTNTTDIDADENETPKEEGCSNNYSWHLLVDNRERIKGAHENLIEVCSRAGAPSVSCTLPCGDFMIGINSPNVGCSANSANVPDYQCRNAAGCTVLREGAMYGQTQKISFLVVERKTVKDLCASITSSRYYEQRQLLSSSPFRSVVWVVEGTMESITVEERRRVLSACASLASLPRFRVVWTRHLSETATFLRSLGKSVGSILCKTKMEQCPETLVTNCTECLQYINKIRKDIQARTTFPRMLMCIRGCSAPLAIQLASKYGSLLGLWRRLKYQGVDACDADPDIHRLTKPQKEVYLCLTKFILTRSYC
Protein: 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Q9VWI1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
Interaction partners:
Sequence:
MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRGELREHERFDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADLIILGLCTHELHFVVLREEVKFGRNVKRTSVEETRFFLLHLGLLREYLELEFDALRTDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNINENGKLNLRRLQIFISALTEVELDHFKEHADDLKYMNNKSEAFDMDVGEITESQNLDSDLGALINKSMLLYDDDSEEDCSDENAVLLKEFQNYKRNFYRNKFKRDPNDELIEELCHHYVNALQWVLDYYYRGVQSWDWYYPFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAKLLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERNRHGPMYVYKYSTVAQGPMPAYPPLRALPVLYCTEVAKWSHEIAVNLPYSVCIELPNAARTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLEDTLTAVASQYLGKVIHVGWPHLVKAIVVRVATRDQRVDSEGITLNDSRRFDSECKALQEHFINRMGIQFANYDVLVYVRTFAGNSTEFRDKGALMVRDSWSSSVTGYPAQGVVADLTVWERMRKNFLNVEHYFPVGSTIFLITDPYYGSEGTVQDPRLAYTNGRIQVSIMVRPEPKVNAARQLQEERDRDYLSTFQVCNLLRISGRTLGRLSGTVWVVLGPRRQKMENVTKHNIGLQLKYPRQNEERAGYCFRTNNQWYYSSLAVDLMRNYCQRYPDVIDFFGDSNDRAEFVFEQDVFPNAVGHRRVEELANWVRQQPHMKVERISCGSKTVCRETIELLIAAVDDLRSLPVKHVKLQVKPHLLIKPNVTLPDVYRSKRPVRLFDRVVIVRTIYMVPVGTKGTVIGIHPVTDPNPVRLECVHAVDTFCKVLFDSPVPNCNNIHGIAEDRVYKVPEIALVIIKTDEEGKKQNDCELPVRDPQPNQAQDEPVRATSSRYVTAAGSTSVPITMKTQISDEFVKTRSDPIARTDSYKPSSEPKPVPVPEQITNWRERVSTPTNKPQPAPNNWRINRSSSRQQGGSIFVAPPTKTPDAAASTASTAFTAASSATLTPLDQTLALMSVLGVGEDQSSPPLQEAVQQQRPPLLQQQRAPFPGQMPNLPKPPLFWQQEAQKQEALQQEAQQQEAQKKQQQAHAQMEPERINSQHFYRSGQTGAALNQPPLGAPSKRQWHEWVHPRMQHANAFHAGVNNGYQMRPKKNIAAQSTFNNNVHMHLQQPYYPNQQQQQQQQQPLQLTEINNAPPRYSTIQDFVPIQAYRPKKLNRVQPAGRQDVDATKNPSRSPVLQQPTNETIDTKASSSLPVQSAGEQVIGLMQTLEIKPAASQSESDGVSTGSANAPTATTSSQAVNRRKHRVPRIGAKFDLEYILPDSPHPT
Protein: Arabinosyltransferase XEG113 (EC 2.4.2.-) (Protein LATERAL ROOT DEVELOPMENT 5) (Xyloglucanase 113) (Q8VXZ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the arabinosylation of cell wall components. Involved in the arabinosylation of extensin proteins in root hair cells. Extensins are structural glycoproteins present in cell walls and its arabinosylation is important for cell elongation, root hair cell development, lateral root development and root hair tip growth.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21680836}; Single-pass type II membrane protein {ECO:0000305|PubMed:21680836}.
Interaction partners:
- Arabinosyltransferase RRA1
- Hydroxyproline O-arabinosyltransferase 1
- Hydroxyproline O-arabinosyltransferase 3
- Hydroxyproline O-arabinosyltransferase 2
- Prolyl 4-hydroxylase 5
- Prolyl 4-hydroxylase 2
- At3g57630
- Extensin-3
- Hydroxyproline O-galactosyltransferase GALT2
- Prolyl 4-hydroxylase 13
Sequence:
MVEGWRNGFRDATNSKPLFVTIYATVIIGVLVSSFYVFSAIYSPTNGSSSFLSFPPLSTSGRIHSLPQENATLELPVAPPPPPQALPPPVLEEAQGNSLGKIWVSPPRDKKMPPLETFKLTKELFGERVKDNVIIVTFGNYAFMDFILTWVKHLTDLDLSNILVGAMDTKLLEALYWKGVPVFDMGSHMSTVDVGWGSPTFHKMGREKVILIDSVLPFGYELLMCDTDMVWLKNPMPYLARFPDADVLTSSDQVVPTVIDDSLDIWQQVGAAYNIGIFHWRPTESAKKLAKEWKEILLADDKVWDQNGFNEIVRRQLGPSVEGDSGLFYAYDGNLKVGILPASIFCSGHTYFVQAMYQQLRLEPYAVHTTFQYAGTEGKRHRLREGMVFYDPPEYYDSPGGFIAFKPSIPKSLLLDGKHTIESHFILVNHQMKQIRSALAIASLLNRTLVMPPIWCRLDRLWFGHPGTLQGSMTRQPFICPLDHVFEVNIMLKELPEEEFGPGIGIREYSFLDNPLLPKQVKESWLDVQLCQEGKEGCEASNNTSPSRVLKFPKRSNEDTFKAIFSSFDDVKVIKFSSIEDAFIGFSDKEREERFRRRVKRYVGIWCCEENKTPGHIYYDMYWDEKPGWKPVPPQTPEEDHPPL
Protein: Alpha-synuclein (B5G015)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSRTKEGVVHGVTTVAEKTKEQVFFVPPAVVTGVTAKTQKTVEGAGNIAAATGLAKKDQLAKQNEEGFLQEGMVNNTGVAVDPENEAYEMPPEEEYQDYEPEA
Protein: Serine/threonine-protein phosphatase PP1-delta (EC 3.1.3.16) (CeGLC-7-delta) (Glc seven-like phosphatase 4) (P91420)
Organism: Caenorhabditis elegans
Function: Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.
Subcellular location: Chromosome {ECO:0000269|PubMed:16943775}. Cell projection, pseudopodium {ECO:0000269|PubMed:22042574}. Cytoplasm {ECO:0000269|PubMed:22042574}. Note=Co-localizes with MSP in oblong stripes in the cytoplasm of inactive sperm and in the pseudopodium in activated sperm. {ECO:0000269|PubMed:22042574}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase ssup-72
- pre-mRNA 3' end processing protein pfs-2
- WD_REPEATS_REGION domain-containing protein
- MEiosis-to-MItosis transition associated
- Serine/threonine-protein phosphatase PP1-gamma
- MFS domain-containing protein
- Cleavage and polyadenylation specificity factor subunit 3
- Probable cleavage and polyadenylation specificity factor subunit 2
- Probable cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 4
Sequence:
MTATIDVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSLRKG
Protein: 4-nitrophenylphosphatase (PNPPase) (EC 3.1.3.41) (P19881)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: PHO13 is dispensable for vegetative growth and sporulation.
Interaction partners:
- Xylulose kinase
- D-xylulose reductase
- Transaldolase
- NADPH-dependent aldose reductase GRE3
- Repressible alkaline phosphatase
- Sorbitol dehydrogenase 2
- Sorbitol dehydrogenase 1
- Dihydroorotase
Sequence:
MTAQQGVPIKITNKEIAQEFLDKYDTFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGIDVKEEQIFTSGYASAVYIRDFLKLQPGKDKVWVFGESGIGEELKLMGYESLGGADSRLDTPFDAAKSPFLVNGLDKDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDSTFPQKGYTFPGAGSMIESLAFSSNRRPSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGGTLLVLSGIETEERALKISHDYPRPKFYIDKLGDIYTLTNNEL
Protein: Zinc-finger homeodomain protein 6 (AtZHD6) (Homeobox protein 24) (AtHB-24) (Q9ZPW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor.
Subcellular location: Nucleus {ECO:0000250}. Note=Interactions with MIF proteins prevent nuclear subcellular location and leads to a scattered repartition throughout the cytoplasm. {ECO:0000250}.
Interaction partners:
- Cysteine/Histidine-rich C1 domain family protein
- Putative defensin-like protein 80
- 40S ribosomal protein S15
- Protein NETWORKED 4B
- Wall-associated receptor kinase-like 14
- Gibberellin-regulated protein 7
- Pathogenesis-related homeodomain protein
Sequence:
MEVREKKDEKMEMTRRKSSALDHHRLPPYTYSQTANKEKPTTKRNGSDPDPDPDLDTNPISISHAPRSYARPQTTSPGKARYRECQKNHAASSGGHVVDGCGEFMSSGEEGTVESLLCAACDCHRSFHRKEIDGLFVVNFNSFGHSQRPLGSRHVSPIMMSFGGGGGCAAESSTEDLNKFHQSFSGYGVDQFHHYQPKKRFRTKFNEEQKEKMMEFAEKIGWRMTKLEDDEVNRFCREIKVKRQVFKVWMHNNKQAAKKKDL
Protein: Enhancer of polycomb homolog 1 (D4A6E4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT5
- YEATS domain containing 4
- DNA methyltransferase 1-associated protein 1
- Actin-like protein 6A
- MRG domain binding protein
- Mortality factor 4-like protein 2
- Mortality factor 4-like protein 1
- Inhibitor of growth protein 3
- RuvB-like helicase
Sequence:
MEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPVQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDVTDAKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAAPQQPSPAALPGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCLGFARRRVGRGGRVLLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSETNTSDRPSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGPAQPGAHTCSASTQSRSSSGSTHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQANSSSSTAAPQGFVSKTLDSASAQFAASALMTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSALSHQVTAANSATTQVLFGNNIRLTVPSSVPTVNSIAPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
Protein: Gastrokine-2 (Blottin) (Down-regulated in gastric cancer) (Trefoil factor interactions(z) 1) (Q86XP6)
Organism: Homo sapiens (Human)
Subcellular location: Secreted.
Interaction partners:
- Trefoil factor 1
- Trefoil factor 2
- Gastrokine-1
Sequence:
MKILVAFLVVLTIFGIQSHGYEVFNIISPSNNGGNVQETVTIDNEKNTAIINIHAGSCSSTTIFDYKHGYIASRVLSRRACFILKMDHQNIPPLNNLQWYIYEKQALDNMFSSKYTWVKYNPLESLIKDVDWFLLGSPIEKLCKHIPLYKGEVVENTHNVGAGGCAKAGLLGILGISICADIHV
Protein: Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4) (Q9P1U1)
Organism: Homo sapiens (Human)
Function: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Interaction partners:
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 2/3 complex subunit 5
- Actin nucleation-promoting factor WAS
- Actin-related protein 2/3 complex subunit 4
- Actin, cytoplasmic 1
- Actin nucleation-promoting factor WASL
- Actin-related protein 2/3 complex subunit 1B
Sequence:
MAGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVDDLDFFIGDEAIDKPTYATKWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS
Protein: Transmembrane protein (Q57YN9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- T. brucei spp.-specific protein
Sequence:
MIVRLLFFSYFLLLLTATQLTAQVTDESTTITFAHEIGPVEKLKQPQLLWFLTWRSSDEQTTSMASVNAPAGELAVTLNTEAQQLTKYVAGLQCEESRKLNAGFRSGRCTLLLTACEAEERADVFFNYRVTKHIEHDTTLGDTATHVSKLYEEGDNEDAVEVGTVTYSVENSSDDERDPSVAFILEFNLTVKAGGCKNWIPSWLKVEGLSPDEVEMRTWRRRAATSVVERWGYPLLLAAAVYGALHALTAIARRHQQAAAEKRKKMK
Protein: Nascent polypeptide-associated complex subunit beta (NAC-beta) (Beta-NAC) (Q92371)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. {ECO:0000250}.
Interaction partners:
- Nascent polypeptide-associated complex subunit alpha
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL23B
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL5A
- Large ribosomal subunit protein eL39
Sequence:
MDPSKLAKLQAGARIGGKGTPRRKVKKPSKSAMSAADDKKVQGALKKLNMQNLAGIQEVNMFKEDGGVINFRAPTVHSSLPNETTAIYGKAEEKTLSEILPGILNNLGPESLTALRQMAEQLKVSEGEKGADAQADDGEIPDLVEKFDEQD
Protein: Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Threonyl dipeptidase) (Q9D1A2)
Organism: Mus musculus (Mouse)
Function: Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (By similarity). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (By similarity). Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96KP4}.
Interaction partners:
- Carnosine synthase 1
- Histidine ammonia-lyase
- Interleukin-13 receptor subunit alpha-2
- Histidine decarboxylase
- Beta-Ala-His dipeptidase
- Carnosine N-methyltransferase
- 4-trimethylaminobutyraldehyde dehydrogenase
- Acidic amino acid decarboxylase GADL1
- Aldehyde dehydrogenase, mitochondrial
- 4-aminobutyrate aminotransferase, mitochondrial
Sequence:
MSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLKN
Protein: Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) (Q9UHW9)
Organism: Homo sapiens (Human)
Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12368912, ECO:0000269|PubMed:17893295, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q924N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q924N4}.
Interaction partners:
- STE20/SPS1-related proline-alanine-rich protein kinase
- Serine/threonine-protein kinase OSR1
- Spatacsin
- Galectin-9C
Sequence:
MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
Protein: Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) (P14174)
Organism: Homo sapiens (Human)
Function: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Subcellular location: Secreted {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:2552447, ECO:0000269|PubMed:8234256}. Cytoplasm {ECO:0000269|PubMed:11089976, ECO:0000269|PubMed:19454686}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269|PubMed:15908412}.
Interaction partners:
- HLA class II histocompatibility antigen gamma chain
- C-X-C chemokine receptor type 2
- C-X-C chemokine receptor type 4
- COP9 signalosome complex subunit 5
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Tyrosine aminotransferase
- 4-hydroxyphenylpyruvate dioxygenase
- Putative aspartate aminotransferase, cytoplasmic 2
- L-amino-acid oxidase
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Protein: Alpha/beta-Hydrolases superfamily protein (Gb|AAD29063.1) (Q9FNG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Disease resistance protein
- Jacalin-related lectin 44
- Germin-like protein subfamily 1 member 14
- Protein RECOGNITION OF PERONOSPORA PARASITICA 7
- Putative disease resistance protein At4g11170
Sequence:
MGNLKKSTRSDELSRSGPPQIPNPDWNNLYHRTTVASCLVQGVYAKERDRENNRNGSESLATPWWKSFNFTLDESEILYDAFDGSIYGAVFQNMINYENTPNSIVVPPRYVIALRGTVPSDVSDWIHNSRIVLEKLHGGGKHMHVIRKIYSLVAKHGNTAVWIAGHSLGAGLALLAGKDMAMSGLPVEAYIFNPPISLIPLEQCGYNHELNFVYRLTRDLFKAGIAKVVDLDEGQEGPRYKNLASWRPHLFVNQSDVICSEYIGYFNHVVTMTEAGLGEISRLASGYSVRRMLFGDGENWSSSSTPDHLHFLPSAFMIVNKTEASEFYNKHGIHQWWNHMLKQSTTFSSY
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (Q580B2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Interaction partners:
- pyruvate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta
- Cytochrome c
Sequence:
MRCLFASATPRCSNRALKKFLEVPLRPMDLRDMKGNDRQHIRAAVEQLTARTARSYRAFASQILKRNLDRETAAQLVPLESICKSEFERCVALTEMVDPYLQQPESDKVCDVGSTLSSEISDGEGVDKALEFSEDAQDSVQTRFIDLLEGLRPRENLLDVAVNEKCINSPDVNYWIYCFCRRRVSWRVIHEHLLHLVGPGRFGPVIRVDPCVASLLQHAGMVVIDLYTRVVQAAHGGSLAITVEERPNLFTTLPAGQLATSSITVSPTARPGCGPQAQPSDVVRSVEGHLAYVFREIIKNACVALMSKATDMELKVYFATNDTHVIVDVVDTADGVSLEVAGKFWQFGWSTNTSLCQLISGFGLGLPVSKVYMDLWNGRIDIYTTPGSGTTVRVTFPKAPVEVLLPEMSAPW
Protein: Roundabout homolog 3 isoform 1 (Roundabout, axon guidance receptor, homolog 3 (Drosophila)) (F1QFK4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLRYLIKTLLQMNLFTDTIRDATNGTDLFFNISSIPSFNSSLLDWANFTGLNGSRPRLEDAAPRIVEHPSDLIVSKGEPATLNCKAEGRPTPMVEWYKDGERVETDREDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGVYVCVARNYLGEAVSRNASLEVAILRDDFRQTPSDVVVAAGEPAVMECIPPRGHPEPTISWKRNNVKVNDKDERITIRGGKLMISNTRKSDAGMYVCVGTNMVGEKDSDPAELVVFERPMFVRRPVNQVVLADDTVDFQCEVQGDPAPTIRWKKEEGELPRGRFEIRADNSLRLTQVKAEDEGSYTCLSENSVGKAEASGSLQVHVPPQIVVRPRDQISAQGRTVTFLCGTKGNPPPAVFWQKEGSQVLLFPSQPPSQSGRFSVSLSGELTITDVHSEDSGYYICQAISVAGSILTKALLEVESTPSDRIPPIIRQGPANQTLAPGTTAQLQCHVMGNPLPSIQWERDGQRILGIDERISLMENGTLQITALQETDSGAYTCVASSLSGETSWSGVLTVKESGGLSASPVSEPYQLPGPPQKPVVTDVTRNSVTLTWQPNAHEGGAAVTSYIIEAFSQSAGSTWQTVADFVKLEKHTVTGLSPNTIYLFIVRAVNAYGLSDPSPISEPVRTQDVSPTGQGVDHRQVQRELGEMSVQLHEPVLLTASSVKISWNVDRQSQYIQGYRLLYRPVGGSWSQQEVKGATERSAVIANLLKGTEYEIKIRPYFNEFQGLDSRSQTLRTPEEVPSAPPRAVNVATVKLSNSSSISVSWQPPPTDMQNGVIQEYKVWCLGNDSQTRYNINQTVDGSVLSTVLKGLLPGVLYQVEVAAVTSAGVGKHSQPVSVLIKLPAEQPTVTGGGSESEENVSLAEQITDVVKQPAFIAGIGGACWVILMGFSVWIYCRRKKRKELSHYTASFAYTPAVGFPHGESSGLNGRPGMLGANMGNYPWLADSWPTTNLVHNGKDSVNCCTSKHETPERYYNEAGISNYLNQNEKYSADSNEGPIYSTIDPTSEDLRSFTAQYSQHTTPYASTPIMPFTNQAPCSPEQDGSHWMTQPGTSNAQYAQPDRSKTENVKQPKQKLMGKPVKTPSLNWMDALPPPPISGDLEQCDEEDDNELIQDMGSDEEEWCPPLPERSYLMDGMVEDGPVPPPRGEASSPTTSYSHQSTATLTPSPRDDGHFHDIPRLHQLEQPHMTRRLPCGPVPVPRAPSPPLTQSNPNLSANQECPDNTVPHRSAHKRDLSQGAAQSVENISNTTPGRARPSADHTSSGQKSKVKKKASKSAQYRRDILQGDLPPPPEPPPEDQDNCAHVGGFECGQTSLERAGSSNSSMERREQSTPNRKNSAHRRIDDDDLIPYNKPNFLSRGQMSSNCSTTGSSSSRGSTGSRGQGTGRKRNDEMR