wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q57W73)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCAMEYSDYTVGLSHLWHMHHLAAVRLQSGKGITGLPYIDFRNPETMDHPQLATDAIVRRLHRRIAADEQHIVKANYHLRDVICNAGDPTYRRRRNMNNLPTEEEVATCLNSAKHTAALERARLNRVKNIQRENYILLEHLKNTKCSVTSAKELNRWYNNEYKKRSRMTRHFKPREPFCGARVLTAECKFTPGTNPDYVTSQALVETPSLWMHRREPTVVEVLAKGPVLPSLQEAANQYIEGCCYTDAKTGVPHLLSRSKGGKRGKAEWKGISKLDVKLMNYANDLKLVRGGNLPIVRRGEENGITSLWRGELEKRSPTRCQGPPWRWLGATEKSNEEKAGGQHQSVNTIVPGRWDPHRSIMGRVRKLALLKDKRHQYAKDAKDGNARRENRRPPYGVPVIPPAAAGGFPFNGSTDAQIPYGMQRLQNRLSTEVPYAQNGHYAEGMPGPVAFPSNAYGESTKTVDSSGPHGFHDFSQLKNYRLGSQGTPASSISRNFGDADAEAPQYVSG
Protein: Tay bridge, isoform D (X2JC54)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDTSNASAKSKTSASGSSSINGIGSQIKHISSSQDIGSSVPAVPVQDEKSESHSHSHSHSSSSSQSSQSQSQSQPQSTVLTVVGQSISKSSTGALAVLHLPPPTATALVQASANIADLGSMPRARPSFVSNTSSTAATTTTATSASDGGKTMAVAAIPPASPVSISEPTCPSVSTVSMAPSACDFDSDTELSIVAAAAAVSASAGIDSRSPTSPPTAAGSTIMPQLNSSAGGTASIAGNQSGFGAGSGAVAAGNTNGHSTTSSSSTHLSLNAKQQRQQKRRRERAQRLQAERDSRCNANSLSGTFIAGSSVGVGSAMSAANGGQGGGVGLVTPNSSVGGGSSAVAMGNGSAAGPGNNGMIYHINSAGSMGEDSNNSNGNFTSSSNGSNNLLPPTDSIASLLLNPPHSPECNSGLMATPSDSEGESLDEDLLSTSSSSTLLLPRDKPPPRPPPPVRRKLPRSPVLEEEIIDGFAILEFKTYEDLEFAIKLGQKRKEKRLSALDELTCTYSIEEMKIPKVIDTGQSQPLRVTSLSTLTVNNNNLKENPQPSLHRDRGGNVISNNNNNNSSNNNNSMINSNGPNANSNSSSLSNVVYLLPSVNMVGNVLETEAEPRDHWRSEYGQQQDQLQSDNSANSKSNNNISDDNQINNSSHQINHTTNNQSSKQQQAADGGCNAAKMQVNNSATVSTRFLENDNDSLMLDISLPSLGVGGAVSHSHDHIDVGVIHASCTGSSSDTKKSHNSPATSNTIDQLHVTKPLPTHQLNNLISSDLNAAANANANSNHLGVCKLGSQSAQVAKSMGLENIETVTNSATCRSLDIQELANVSAQSFGASSSSSSSSISIKKENEQSDLLNDASTNCSSNSKGNNICDNVSNDKKNSEQIFDIDNPPTPMNISNTSSCSDRSSSRKFSELPHLKKKSAACGDRDNGPYAGVPFAAAMGTVSPDSDPSKALNIKNASESASGKAVHAHAGAPIPPPPAASVGDPGNRELGVLQKTSPDKPLYPNLCAPPSVSSVQFPNVGISAGNEKIASTVASDIDQKIIFNSKATASVSNGLSSGVQRSIVPLLSAAPSPAAVTLSSPFSAHIAAAPNAAGLSILSSASSVILANSSIKNTNNGSNNGSANGQGQLSSVGLSSTSEIAKSNSVPTTSSPPNPMVNGFLSVYPPPAATIATSSVTTSALSRVSPNAANKLVPPVSATTSISINTNYVGISGGTTTTSGMGKVVFGAGGNAIVGTGSPLLFPGAPPAPISHVATGVPMIIQAPPYRAPYTNYPLYTPYSGLTHGSYLPPVLPVATPNLSNLPPTQHRSSDSRNSRESPASLKSTPSNIGLNVSMAPTLRSITPLNNSSAISSGASQPVVSVVPSANSTALSMSNPHISHSHHVPAYASGAFSSSAAAGTSTPNSGLSTLAVTSLSTSAAPQPHSHFPQSTQMLPQSGNFSSVSHLLTTHPMSSQNQPMVRCGSTLYSQSSAAATAPPSAAAAVSNFTPSVLAVQSLTTAVTSSSSSPSTLSSSVIQKVISPKGESPCNKDRDSSYSTNIRSHGASTMLPGASQGIGLGSSFCGIAPSQYGGTGTPVLSSSSSMPPGLGNLSSYSSKAALWLNSPANAVVTTCAPTTPIVSSGSARPTPPLSNCTSMGIGMVNAASTARSSCNAISPLSIPATAGIHVSATNPSFQSSSYFPTPLAPPPSSPSPATSSAAIISSSASQFNPAVSHSMSSIVTTAGATTTTASSVTQPSVAAISNPVTNTPHPFSAESLFQPSKNDQADLLRRELDSRFLDRSGLAVTPTPPSSTYLRTDLQHQQHAHLHQHPQLLPPVSAPSTPLSAVQPSSGQIFPPPLFKDISKISSVDPQFYRTGMGLPPGGYSGYTSAGLLHSGLGGPTPFMPPNHLTSFAPKKTGRWNAMHVRIAWEIYYHQNKQSPEKQPGFPTASSNAGSINAPIPPGNMISGGGGGMASGASTPVNNVAAIPAVGGGVLVSNGPPSVLGMKTTPTLGMSSTPQHILHRASEMPPSAAFPGGLPGRLAFETSPLAASFIGAPPSHIGTAVSPFGRYVTPFGFTGLTHFGGHLDSWRTNAMQRSVAYHPSSAAPSPNWPVKSDPGLDNARREAEERERELRDREQRERDRQRREREERERKEKEEKLKREQQERERERERDRKERERERREIERREMERERMLQQQRINESNKQAAVQAAAAATAPVRDRSPHRNVGELNTEIRIKEEHPRTKEEQDVMLLRASAAAVGVGDPRYHSSSLAAAQASAAAAAAHHHHANFMAASRHGLPPPPSHLTRTMMPPTLSVGGPITHFGAPAPPGWGIDPYRDPYPILRYNPIMEAALRHEAEERQKAINIYAAQSAAHLRSKEPSPIPPSVGSLGPPPPHHRLQIVSSVAQSGVQQPGPPSQQQQQQMSSGGGMVKNSGGPQAPGSIPVQHMISVDSMGQQSVSAKKESDHTMGIVSNAGVGLSSVPGGVIGISPVSSVAPSR
Protein: Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) (Q62782)
Organism: Rattus norvegicus (Rat)
Function: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAATAKGAAGATGAKKGEARCSSEDDDSKESTCSHTPDSTASLPPPPPAPSLASPLLSPSPLPAALGSGPGPQPLKGALWAGVAGGGGGGPGTGAAELLKAWQPAEPGPGPFSGVLSSFHRKPGPALKTNLF
Protein: Protein OPG035 (Protein N1) (P17361)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
Interaction partners:
Sequence:
MRTLLIRYILWRNDNDQTYYNDNFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK
Protein: DNA helicase (EC 3.6.4.12) (A0A0C4DGG9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRGVCGRPRPPPMGRSTRAVGPAHLPSLPPDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Protein: Protein Hikeshi (Lethal gene on chromosome 7 Rinchik 6 protein) (Q9DD02)
Organism: Mus musculus (Mouse)
Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). May also be indirectly required for organization and/or function of the secretory apparatus in Club cells in lung.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16157679}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q53FT3}. Nucleus {ECO:0000250|UniProtKB:Q53FT3}.
Interaction partners:
- Heat shock 70 kDa protein 1B
- Heat shock cognate 71 kDa protein
Sequence:
MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGVPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSLAQQTPVGSAAVSSVDSFTQFTQKMLDNFYNFASSFALSQAQMTPNPSEMFIPANVVLKWYENFQRRLAQNPLFWKT
Protein: ABC transporter, ATP-binding protein (O53247)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAVHGFLLERVSVVRDEATVLRQVSAHFPAGRCSAVRGASGSGKTTLLRLLNRLIDPTSGKVWLDGVPLTDLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVGRPDLPEGRVTELLARLCLGQSAREAFLPHQRSALRTALIPAIDSTKVVGLISLPGAMSGLILAGVDPLTAIRYQIVVMYLLLAATAVAALTCARLAERALFDRAHRLVSLPAATRRA
Protein: Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) (P18762)
Organism: Mus musculus (Mouse)
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2834198}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P07550}. Early endosome {ECO:0000250|UniProtKB:P07550}. Golgi apparatus {ECO:0000250|UniProtKB:P07550}. Note=Colocalizes with VHL at the cell membrane. Activated receptors are internalized into endosomes prior to their degradation in lysosomes. Activated receptors are also detected within the Golgi apparatus. {ECO:0000250|UniProtKB:P07550}.
Interaction partners:
- Beta-arrestin-2
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Na
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- S-arrestin
- Beta-1 adrenergic receptor
- Guanine nucleotide-binding protein G
- Beta-3 adrenergic receptor
Sequence:
MGPHGNDSDFLLAPNGSRAPDHDVTQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKKAIDCYTEETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRDNLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEPNTCQLGQEREQELLCEDPPGMEGFVNCQGTVPSLSVDSQGRNCSTNDSPL
Protein: Guanine nucleotide-binding protein subunit beta-like protein (Q383M9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNVDDFRTVIPSPVYVATRGERSGINVAVRALAPVTDVVFDMEEQFAVVCQRRRFSTYAISSWMESLDVPSIPGAAVPLVSVEPQGFSSLGFALSALQFLSSSLHVIAGYHRAPVVDIFDLENVDEETSEPQQRFNLTDVKENGNVEDGSSAYANDVMPMDRYVSLGALSSGLSVWLDSRSGKAEACTGVLTRQYTIGAHNRHTGRRDPLACVTSLCQGNPANILLGTEAGALQLWDVRCARECVAQHMTSASICRLHPSYSYPLRNVVWLNTLAGCVEAVSVGQSDMELLARRLCPDFQRSSSTFHLPPPRLSFMESSGVVACPHISSGKLLLYDGSSLVKQPNNSRTQLSSYNRGVDGKDNEYENGHCSNFGGFLREASSSSEESGEREIPLLNALPSEANALVTACTVWSNRDMFVLGDETGRVQLL
Protein: Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) (P60825)
Organism: Rattus norvegicus (Rat)
Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity).
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.
Interaction partners:
- Toll-like receptor 4
Sequence:
MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSYRDSYDSYATHNE
Protein: Laccase (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase) (Diphenol oxidase) (Urishiol oxidase) (B3A0L4)
Organism: Hericium coralloides (Coral tooth fungus) (Hericium ramosum)
Function: Lignin degradation and detoxification of lignin-derived products. Has activity towards ABTS and, to a much lesser extent, towards N,N-dimethyl-1,4-phenylenediamine, catechol and 2-methylcatechol.
Subcellular location: Secreted {ECO:0000250|UniProtKB:D0VWU3}.
Interaction partners:
Sequence:
AVGDDTPQLY
Protein: Signal peptidase complex subunit 3 (Microsomal signal peptidase subunit 3) (Q10259)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Signal peptidase complex subunit 2
- Signal peptidase complex subunit 1
- Signal peptidase complex catalytic subunit sec11
- Mitochondrial inner membrane protease subunit 2
- Mitochondrial inner membrane protease subunit 1
Sequence:
MIVDTFTNRGSTFFSKLSTVLFFLCAVITFQGVIQRREVELDTPVYVHYAKYRSARFYHAFRNVRQQYAQVKFNMDADLSELWDWNTKHVVVYLVASYSTEKHEKNQVVVWDKILSSPEESKMFMKDTLSNIQAHPFNEYSNQFEGKNATYTLHWTVSPKMGFLSWGAGPGSYEIPFHKIITQPK
Protein: Protein phosphatase 2C, putative (EC 3.1.3.16) (Q387H4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGVSLPKPVMTHLRERCGNDIFRCGSSCVNGYRESMEDAHLVYLQPSWGFFGVFDGHVNDNCSQFLEGAWRSALEKESMPMSDDRMKELTLAIDKEWMDKACDGGSTGTFFVGMKENNTVHLQVGNVGDSRVLVCVDGKARAMTEDHKPNNADERRRIEECGGRVESNRVDGSLAVSRAFGDRDYKANPSGGQLSQKVIALPDVTHVDVTWDSKDFAVLCCDGVFEGQFSNEEVVDFIKEQMEQTDDLGLIAGRVCEEAVNRGSRDNVSCVIVQFKSGKDYATAEHLEVVPGPFSVPRNGTFRKVYSLMAEKGGMTTQEVLEKRYDYLASLEDKTAHMEEWKGFKDGPPANLEGKERTEWFSELFEQYAAETPSDPRSDNMERIQMLQQQIGIPLPMLLSIMSGQSEE
Protein: L10-interacting MYB domain-containing protein (Q9FFJ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that associates with ribosomal protein promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:25707794}.
Interaction partners:
- Large ribosomal subunit protein uL10c
- Protein NSP-INTERACTING KINASE 1
- Protein NSP-INTERACTING KINASE 2
- Large ribosomal subunit protein uL16z
- Protein NSP-INTERACTING KINASE 3
- Large ribosomal subunit protein eL30y
- Protein EMSY-LIKE 1
- Transmembrane receptor
- Small ribosomal subunit protein eS25y
- Wall-associated receptor kinase-like 1
Sequence:
MRPKAVWEPEYHRVFVDLCVEQTMLGNKPGTHFSKEGWRNILISFQEQTGAMYDRMQLKNHWDTMSRQWKIWRRLVETSFMNWNPESNRFRATDDDWANYLQENPDAGQYRLSVPHDLKKLEILFAGCNVEVKNDEVSGVRKRRRSCYEEEDEDNQSMCSSSNPQTKGYWSPSTHKLFLDLLVQETLKGNRPDTHFNKEGWKTILGTINENTGLGYTRPQLKNHWDCTRKAWKIWCQLVGASSMKWDPESRSFGATEEEWRIYIRENPRAGQFRHKEVPHADQLAIIFNGVIEPGETYTPPSRSRKKLLHNRSESPQWRDTTPLSKMHVDEAETSRQNGCYAESQEDRIDSENAQPLDDMKLMNDVMLQESPVFVEIESAKPMYSIGECIKSLNAIEEVEQGSELYMFALDLFLKREYREIFLELKKPSLRIAWLQRLQSTSFPIPTTT
Protein: Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) (Q15291)
Organism: Homo sapiens (Human)
Function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
Subcellular location: Nucleus {ECO:0000269|PubMed:17355966}.
Interaction partners:
- Protein dpy-30 homolog
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Histone-lysine N-methyltransferase 2C
- Histone-lysine N-methyltransferase SETD1A
- Host cell factor 1
- WD repeat-containing protein 5
- Histone-lysine N-methyltransferase SETD1B
- PAX-interacting protein 1
- WD repeat-containing protein 82
- Histone-lysine N-methyltransferase 2A
Sequence:
MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL
Protein: Midnolin (Midbrain nucleolar protein) (Q504T8)
Organism: Homo sapiens (Human)
Function: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q3TPJ7}. Nucleus {ECO:0000269|PubMed:24187134, ECO:0000269|PubMed:37616343}. Cytoplasm, cytosol {ECO:0000269|PubMed:24187134}. Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134). {ECO:0000250|UniProtKB:Q3TPJ7, ECO:0000269|PubMed:24187134}.
Interaction partners:
Sequence:
MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAARGDPSIASPVSSPCRPVSSAARVPPVPTSPSPASPSPITAGSFRSHAASTTCPEQMDCSPTASSSASPGASTTSTPGASPAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPPSLAQLRCHAQCSPASPAPDLAPRTTSCEKLTAAPSASLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGRSDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEFVVA
Protein: Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) (P22717)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm.
Interaction partners:
- Guanylate cyclase soluble subunit alpha-1
- cGMP-dependent protein kinase 2
- Guanylate cyclase soluble subunit alpha-2
- Nitric oxide synthase 1
- Inosine triphosphate pyrophosphatase
- cGMP-specific 3',5'-cyclic phosphodiesterase
- cGMP-dependent 3',5'-cyclic phosphodiesterase
- Phosphodiesterase
- Molybdenum cofactor biosynthesis protein 1
- GTP cyclohydrolase 1
Sequence:
MEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPNVRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRNTDHQQQVYKGDPADASNEVTLAGSPVAGRNSTDAVNNQPSPDETKTSVVASGPVLSAFCVVL
Protein: LIM domain binding 2 (H0YA09)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ
Protein: Ribosome quality control complex subunit 2 (Microtubule regulator protein 1) (Q9USN8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell. Mtr1/rqc2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Mtr1/rqc2 is important for the stable association of the E3 ubiquitin-protein ligase rkr1/ltn1 to the complex. Mtr1/rqc2 recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails). CAT tails induce a heat shock response.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24928430}.
Interaction partners:
- E3 ubiquitin-protein ligase listerin
- Cell division cycle protein 48
- Ribosome quality control complex subunit 1
- Small ribosomal subunit protein uS13A
- tRNA endonuclease vms1
- Threonylcarbamoyl-AMP synthase
- Ubiquitin fusion degradation protein 1
- Nuclear protein localization protein 4
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL29
Sequence:
MKQRFSALDIAAIAAELREQVVGCRLNNFYDLNARTFLLKFGKQDAKYSIVIESGFRAHLTKFDRENAPLSGFVTKLRKHIKSRRLTGVSQLGTDRVLVFTFGGGANDQDPDWTYYLVCEFFAAGNVLLLDGHYKILSLLRVVTFDKDQVYAVGQKYNLDKNNLVNDNKSQSTIPHMTAERLNILLDEISTAYASPTSINEPLPDQQLSSSTKPIKVPKPVSLRKALTIRLGEYGNALIEHCLRRSKLDPLFPACQLCADETKKNDLLAAFQEADSILAAVNKPPVKGYIFSLEQALTNAADPQHPEECTTLYEDFHPFQPLQLVQANRKCMEFPTYNECVDEFFSSIEAQKLKKRAHDRLATAERRLESAKEDQARKLQSLQDAQATCALRAQAIEMNPELVEAIISYINSLLNQGMDWLDIEKLIQSQKRRSPVAAAIQIPLKLIKNAVTVFLPNPESVDNSDESSETSDDDLDDSDDDNKVKEGKVSSKFIAVELDLSLGAFANARKQYELRREALIKETKTAEAASKALKSTQRKIEQDLKRSTTADTQRILLGRKTFFFEKFHWFISSEGYLVLGGRDAQQNELLFQKYCNTGDIFVCADLPKSSIIIVKNKNPHDPIPPNTLQQAGSLALASSKAWDSKTVISAWWVRIDEVSKLAPTGEILPTGSFAIRAKKNYLPPTVLIMGYGILWQLDEKSSERRKARRLEMEVVETQGKVSELKMEGTSVTSEDNIQDVVSEVSYNEDTNNQSTPDTTGSDIHIVSEKRGKKGSKVITAKKVSAKERREARRARRQTALEESLKAPISIEDATDPQTILAILKQKKAKKKHAAREMEISSQIPSNDSSNVQTPTAESEIEEDGVSEPISAEVIEDQSRNSEAENEKGLSTEQRDEKKHAKVESFQRQEMPRSLFEEIFFAIDSLTPNPQQQDTVINAVPTFAPYNAMTKFNQKVKVMPGTGKVGKAARESIAYFMKKLPKSSKEAAYLENLKDGEIVAPISVSRLKMVFGSSGNTKKSKK
Protein: Prickle homolog 2b (Prickle-like protein 2b isoform X2) (F1REQ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Vang-like protein 2
- Vang-like protein
- T-box transcription factor TBX1
- Dishevelled segment polarity protein 2.
- Ankyrin repeat domain 6b
- Dishevelled segment polarity protein 1b
- Cadherin EGF LAG seven-pass G-type receptor 1
- Dishevelled segment polarity protein 3b
- Dishevelled segment polarity protein 3a
- Inversin
Sequence:
MPLEMEKTVTKLMYDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSSLPEDKVPYVNSPGEKYRIKQLLHQLPPHDNEVRYCNSLDDEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPQCFVCSMCDELLVDLIYFYQDGKIFCGRHHAERLKPRCSACDEIILADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCTCFESLYAEYCDSCGEHIGIDQGQMTYDGQHWHATEACFSCARCKKSLLGRPFLPKQGQIFCSRACSVGDDQNGSDSSDSAFQSARSREARRSSSKSNKSSTGGSGGDGHQSGKASAMRFSADVDPLSLQMDLLSLSSQTPSLNRESPSWKTQAEMFGYEGRNELSTNPLHLLSQCNIRTSYSSNLSPGHLSDPRPKEPASSKRPPVSALKGKSLNENWFQQGPEDYYPPALRTQASFNEVPHNSFMDKRSVSLHVFQREKEKDVGPQMSRSRNPISALGFSEQLTPLEQTPRGSMESLALSNATGTSADGGSKRQEHLSRFSMPDLSKDSGMNVSEKSNMGTLNSSVQFHSSESLRSLNSAQPYLELEAPVQVRFPVQYPREPSGINALPPGFAYQEEDRVSLVSNANNARLPPMSERTRRRSIDHEEPRRRHHHHRSRRSRRSRSDNALNLVAERRPAPKRSQLHAREDYDQFPLPRGSRDTYGSGRLRQQPFRPCPRTTSDLTLQNPALHRHQGPYSWDQYDYNDDWCSTCSSSSESEDEGYFLGEPIPRPIQLRHMTSEELLRKYNSSGLGASGQFGSRGQLHMRKRRKSKNCIIS