Protein: ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Epithelial basolateral chloride conductance regulator) (Multidrug resistance-associated protein 2) (Q28689)
Organism: Oryctolagus cuniculus (Rabbit)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (By similarity). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q92887}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP binding cassette subfamily G member 5
- Nuclear receptor subfamily 1 group I member 2
- Solute carrier family 22 member 6
- Bile acid receptor
- Broad substrate specificity ATP-binding cassette transporter ABCG2
- ABC-type xenobiotic transporter
Sequence:
MLDKFCNSTFWNSSLLDSPEADLPLCFEQTVLVWIPLIFLWLLAPWQLFHVYRSRTKRSPITKFYLAKQVLVGCLLILAVIELILVLTENSGQATIPAVRYTNPILYLVTWLLVLLIQHSRQSCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLRDSNSNLAYSCLFFISYGFQILILILSAFSEKDNSSKNPSVTASFLSKISFSWYDSVVLKGYKRPLTLEDVWDIDEEFKAKTIVSRFEVHMAKELKKARKAFQKRQQKKSQKNSRLQGLNKNQSQSQDVLVLEETKKKNKKSGTTKDFPKSWLVKTIFKTFYMVLLKSFLLKLVYDLLTFLNPQLLKLLITFVSDPNSYAWLGYIFAILLFAVALIQSICLQTYFHMCFNLGMCVGTTVMATVYKKALTISNLAKRQYTIGETVNLMSVDAQKLMDVTNFIHLVWSSVLQIVLSIYFLWVELGPSVLAGVGVMVLLIPVNGILATKNRNIQFKNMKYKDKRLRIMNEILSGMKILKYFAWEPSFKDQVHNLRKKELKNLRTFAYMQSVVMFLLYLTPVLVSVTTFSVYVLVDSNNILDAEKAFTSITLFNILRFPMSMLPNVISAMLQASVSVDRLEKYLSGDDLDTSAIQRDPNFDKAVQFSEASFTWDRNLEPTIRNVNLDIMPGQLVAVVGTVGSGKSSLMSAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGAEFDERRYQRVLEACALLPDLEILPGGDLAEIGEKGINLSGGQKQRISLARASYQNSDIYILDDPLSAVDAHVGKHIFNKVLGPNGLLNGKTRLLVTHSLHFLPQVDEIVVVENGTILEKGSYSSLLAKKGVFAKNLKMFVKHTDSEGEVTVNDGSEEDDDDDSGLISSIEEFPEDSISLTLKRENSLHRTLSRSSRSSGRRLKSLKNSLKAQNGKTPKEEEVVKGQKLIKKEFMETGKVKFSIYLKYLQAIGWCSIVGIIFAYVLNSVAFIGSNLWLSAWTSDSNTYNGTNYPASQRDLRIGIFGVLGLAQGLTVLVASFWSASGCAHASNILHKQLLNNILRAPMSFFNTTPIGRIVNRFAGDISTVDDTLPQSLRSWMMCFLAIISTLIMICMATPVFAVIIIPLAIIYVAVQVFYVATSRQLRRLDSVTRSPIYSHFTETVSGLPVIRAFEHQQRFLKQNEIGIDTNQKCVSSWITSNRWLAFRLELVGNLVVFSSALMMVIYRDTLSGDVVGFVLSNALNITQTLNWLVRMTSETETNIVAVERITEYIKVENEAPWVTDKRPPAGWPHKGEIQFSNYQVRYRPELDLVLKGINCDIKSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGHITIDGIDIASIGLHDLRGKLTIIPQDPVLFSGSLRMNLDPFNNYSDEEIWRALELAHLKSFVAGLQHGLSREVSEAEDNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDHLIQTTIRNEFSHCTVITIAHRLHTIMDSDKIMVLDNGNIVEYGSPEELLESAGPFSLMAKESGIENVNNTAFWAAAARDAGAGRLSPGFASVT