wanglab/gogpt-training-data huggingface dataset:
Protein: Polyamine oxidase 1 (OsPAO1) (EC 1.5.3.-) (OsAO4) (Q5NAI7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine and its acetyl derivatives. Substrate preference is thermospermine > spermine > norspermine > N(1)-acetylspermine. No activity detected when putrescine or spermidine are used as substrates. Plays an important role in the regulation of polyamine intracellular concentration (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24105034}.
Interaction partners:
- Aminopropyl transferase
- Polyamine oxidase 3
- Polyamine oxidase 5
- Spermidine synthase 1
- Os02g0254700 protein
- Polyamine oxidase 4
- Os10g0536000 protein
- Os03g0123100 protein
- Os04g0580400 protein
- Polyamine oxidase 7
Sequence:
MVAKKPRVVVVGAGISGLAAAHRLCGAGGDRFEVAVVEAGDRVGGRILTSEFAGHRVEMGATWVQGVVGSPVYALARDAGALGEEEGRGLPYERMDGFPDRVLTVAEGGEVVDADTVAGPIEELYRGMMEAARAGEAGGGGGVEEYLRRGLRAYQAARSAGGGGGGGKELEEVDEALLAMHINRERTDTSADDLGDLDLTAEGEYRDFPGEHVTIPGGYSRVVERLAAALPPGTVRLGLRLRRLKWGGTPVRLHFADGAPPLTADHVILTVSLGVLKASLGNKDTAGVGAAAIAFDPPLPPFKREAVARLGFGVVNKLFMEVEAVAPSEPEDVAGVQPAAAGFPFLHMAFRGHVSKIPWWMRGTESICPVHAGSTVALAWFAGREAAHLESLPDDDVIRGAHATLDSFLPAAPRWRVRRIKRSGWATDPLFLGSYSYVAVGSSGDDLDRMAEPLPRGPDAAADERPPSPRLLFAGEATHRTHYSTTHAAYLSGVREANRLLQHYRGGANHTT
Protein: GDSL esterase/lipase At1g54020 (EC 3.1.1.-) (Extracellular lipase At1g54020) (Q9C5N8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Myrosinase-binding protein 1
- Jacalin-related lectin 23
- Protein trichome birefringence-like 26
- 1-aminocyclopropane-1-carboxylate oxidase homolog 2
- Jacalin-related lectin 5
- Homoarginine-6-hydroxylase 2-ODD-C23.1
- Jacalin-related lectin 42
Sequence:
MECSSVSVLGILLVFPLLHNLVTISGQNLPAVGLFTFGDSNFDAGNKKFLTSAPLPQNFWPYGKSRDDPKGKFSDGKIVPDFIAKFMGIPHDLPPALKPGTDVSRGASFAVGSASILGSPKDSLALNQQVRKFNQMISNWKVDYIQKSVFMISIGMEDYYNFTKNNPNAEVSAQQAFVTSVTNRFKSDINLLYSSGASKFVVHLLAPLGCLPIARQEFKTGNNCYEKLNDLAKQHNAKIGPILNEMAETKPDFQFTVFDFYNVILRRTQRNMNYRFSVTNISCCGVGTHYAYGCGLPNVHSKLCEYQRSYLYFDARHNTEKAQEAFAHLIFGADPNVIQPMNVRELMVYPVNEPMREFWEDPMDEKLSLVQY
Protein: Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (A0A140VJX1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGASAMLIQKL
Protein: N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) (P34059)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome.
Interaction partners:
- Beta-galactosidase
- Formylglycine-generating enzyme
- Adenine phosphoribosyltransferase
- Sialidase-1
- Arylsulfatase A
- Zinc finger protein 276
- Alpha-L-iduronidase
- Lysosomal protective protein
- Alpha-N-acetylglucosaminidase
- Cyclin-dependent kinase 10
Sequence:
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
Protein: Alpha-crystallin A chain (P24622)
Organism: Mus musculus (Mouse)
Function: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P02489}. Nucleus {ECO:0000250|UniProtKB:P02489}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250|UniProtKB:P02489}.
Interaction partners:
- Alpha-crystallin B chain
- Beta-crystallin A1
- Beta-crystallin B2
- Gamma-crystallin D
- Gamma-crystallin S
- Beta-crystallin B1
- Gamma-crystallin C
- Beta-crystallin A2
- Gamma-crystallin B
- Beta-crystallin B3
Sequence:
MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISELMTHMWFVMHQPHAGNPKNNPVKVRSDRDKFVIFLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
Protein: Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); Nucleocapsid protein p12-gag] (P25058)
Organism: Bovine leukemia virus (isolate Australian) (BLV)
Function: The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.
Subcellular location: [Matrix protein p15]: Virion {ECO:0000250|UniProtKB:P03345}.; SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000250|UniProtKB:P03345}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p12-gag]: Virion {ECO:0000250|UniProtKB:P03345}.
Interaction partners:
Sequence:
MGNSPSYNPPAGISPSDWLNLLQSAQRLNPRPSPSDFTDLKNYIHWFHKTQKKPWTFTSGGPASCPPGKFGRVPLVLATLNEVLSNDEGAPGASAPEEQPPPYDPPAVLPIISEGNRNRHRAWALRELQDIKKEIENKAPGSQVWIQTLRLAILQADPTPADLEQLCQYIASPVDQTAHMTSLTAAIAAEAANTLQGFNPKMGTLTQQSAQPNAGDLRSQYQNLWLQAWKNLPTRPSVQPWSTIVQGPAESYVEFVNRLQISLADNLPDGVPKEPIIDSLSYANANKECQQILQGRGLVAAPVGQKLQACAHWAPKTKQPAILVHTPGPKMPGPRQPAPKRPPPGPCYRCLKEGHWARDCPTKTTGPPPGPCPICKDPSHWKRDCPTLKSKN
Protein: bZIP transcription factor TGA10 (Protein TGACG (TGA) motif-binding protein 10) (Q52MZ2)
Organism: Nicotiana tabacum (Common tobacco)
Function: Transcription activator that binds to as1-like elements (5'-TGACGTAAgggaTGACGCA-3') in promoters of target genes. Regulates transcription in response to plant signaling molecules salicylic acid (SA), methyl jasmonate (MJ) and auxin (2,4D) only in leaves. Prevents lateral branching and may repress defense signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
Sequence:
MGFERAFVESSPEQENKLFVGVSYMDSSNKNQDPSESNNQISFGGQHQHHQQQFFYNHHQQQQLQNNNQVSFGMMQQSSSAIPGSLISKDSAGAYDLGELDQALFQYLDGQEPSSIQEQRQNSGMRPPTLNIFPSQPMHVEPSTTNKMNTGLVSPAISGSKRSSQPSMELSNNLKNNDAPSASGPEPPKAAKREGNRKGPTSSSEQDAPKTPDPKTLRRLAQNREAARKSRLRKKAYVQQLESSRIRLTQLEQELQRARAQGYYFGGNSLLGGEQNLPVNLANMSSDAAVFDMEYARWLEEHHRLMCELRNAVQEHFPENELRIYVDNCVTHYDEIMNLKSMLTKSDVFHLVSGMWKTPAERCFMWMGGFRPSELLKIILSQIEPLTEQQLMGICGLQQSTQEAEDALSQGLEALNHSLSDTIASDALSCPQNMANYMGQMALAMNKLSTLEGFVRQADNLRHQTIHRLHQLLTTRQAARCFLAIAEYFHRLRALSSLWHARPRQE
Protein: DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) (Q9VYA5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- ATP-dependent DNA helicase II subunit 2
- ATP-dependent DNA helicase 2 subunit 1
- FI04011p
- Exonuclease 1
- DNA polymerase theta
- Serine/threonine-protein kinase ATM
- DNA repair protein Rad51 homolog
- DNA excision repair protein ERCC-1
- DNA repair and recombination protein RAD54-like
- RE59279p
Sequence:
MSVDIASTIKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRDYGDVVYSVLKPRCFNPPSNLRLKEIHQMLDTIANEDTEVKQQQLIRFTEQASPEEQKWLIRLLLKSLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPMLCERFPGDIQELMQSDVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLESIILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYNRKRTFVDSFLLGVLQPAPPGSSNRPEVFSIGVVANNTKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADLAPNGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLNKRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSASTSKLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQPRTCDIVRMEWLLRVCQKQELELKPRDLIAATEPLQQDLAECFDRHGDSYTKDIANVEELQDLLQGIELTADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFFYSPHGDEVAKLLFLQNGGRIVDDSDPQLNLGFICMSSDIDNDHFEHWLHNHSKLTTDKVLNSAWIHQCHREGILLPMHSFV
Protein: Uncharacterized protein YbhM (P75769)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Modulator of FtsH protease YccA
Sequence:
MESYSQNSNKLDFQHEARILNGIWLITALGLVATAGLAWGAKYIEITATKYDSPPMYVAIGLLLLCMYGLSKDINKINAAIAGVIYLFLLSLVAIVVASLVPVYAIIIVFSTAGAMFLISMLAGLLFNVDPGSHRFIIMMTLTGLALVIIVNAALMSERPIWIISCLMIVLWSGIISHGRNKLLELAGKCHSEELWSPVRCAFTGALTLYYYFIGFFGILAAIAITLVWQRHTRFFH
Protein: Protein TONNEAU 1b (Q9FQ24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the control of the dynamic organization of the cortical cytoskeleton. May play a role in the organization of microtubule arrays at the centrosome through interaction with centrin 1 (CEN1).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18757558, ECO:0000269|PubMed:22286137}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18757558, ECO:0000269|PubMed:22286137}. Note=Localizes to cytoplasm and cortical cytoskeletal structures, including the preprophase band and the interphase microtubule arrays (PubMed:18757558). Recruited to cytoskeletal structures by LNG2/TRM1 (PubMed:22286137). {ECO:0000269|PubMed:18757558, ECO:0000269|PubMed:22286137}.
Interaction partners:
- Probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2
- At1g79390
- LOB domain-containing protein 5
- Gamma-interferon-responsive lysosomal thiol protein
- Auxilin-like protein 1
- Auxilin-related protein 1
- LONGIFOLIA protein
- Wax ester synthase/diacylglycerol acyltransferase 11
- GPI-anchored adhesin-like protein
- At5g26910
Sequence:
MDDYTREMMDLKTLVTRTLEKKGVLAKIRAELRASVFEAIEEEDRVIENNEGLPPALLGSCNDRARQLHASPSGRLLSALICEYLDWAQLNHTLKVYQPECNSAKDSWKSEIRDFSINNGYELNRNEDSRPLLLDVLEGFLKFENMTQVMGGSSRRESETESSLSLDTRNPPRRSSASDSLPHQRRSVSASQASGAATSGYRKDESNWRYDTEDMPEEVMRASTALENLQLDRKTRNLTSSWRNVKDGTSEEEEGKD
Protein: Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] (P23578)
Organism: Mus musculus (Mouse)
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Interaction partners:
- Zona pellucida sperm-binding protein 2
- Izumo sperm-egg fusion protein 1
- Spermatid nuclear transition protein 1
- Acrosin-binding protein
- Protein boule-like
Sequence:
MVEMLPTVAVLVLAVSVVAKDNTTCDGPCGLRFRQNSQAGTRIVSGQSAQLGAWPWMVSLQIFTSHNSRRYHACGGSLLNSHWVLTAAHCFDNKKKVYDWRLVFGAQEIEYGRNKPVKEPQQERYVQKIVIHEKYNVVTEGNDIALLKITPPVTCGNFIGPCCLPHFKAGPPQIPHTCYVTGWGYIKEKAPRPSPVLMEARVDLIDLDLCNSTQWYNGRVTSTNVCAGYPEGKIDTCQGDSGGPLMCRDNVDSPFVVVGITSWGVGCARAKRPGVYTATWDYLDWIASKIGPNALHLIQPATPHPPTTRHPMVSFHPPSLRPPWYFQHLPSRPLYLRPLRPLLHRPSSTQTSSSLMPLLSPPTPAQPASFTIATQHMRHRTTLSFARRLQRLIEALKMRTYPMKHPSQYSGPRNYHYRFSTFEPLSNKPSEPFLHS
Protein: Mitochondrial import inner membrane translocase subunit PAM16 like 2 (AtPAM16) (AtPAM16L2) (Presequence translocated-associated motor subunit PAM16) (Protein MUTANT SNC1-ENHANCING 5) (Protein THAXTOMIN A RESISTANT 1) (Q93VV9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix (By similarity). Involved in the uptake of thaxtomin, a phytotoxin produced by Streptomyces bacteria, that causes dramatic cell swelling, reduced seedling growth, and inhibition of cellulose synthesis. Modulates polar auxin transport. Involved in importing a negative regulator of plant immunity into mitochondria, thus protecting plants from over-accumulation of reactive oxygen species (ROS) and preventing autoimmunity. Confers sensitivity to virulent pathogens such as the oomycete H.arabidopsidis Noco2 and the bacteria P.syringae pv. maculicola ES4326.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:24153405}; Peripheral membrane protein {ECO:0000269|PubMed:24153405}. Cytoplasm {ECO:0000269|PubMed:12897252}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM14-3
- Mitochondrial import inner membrane translocase subunit TIM44-1
- Mitochondrial import inner membrane translocase subunit TIM14-1
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM14-2
- Mitochondrial import inner membrane translocase subunit TIM23-1
- Mitochondrial import inner membrane translocase subunit TIM23-3
- Mitochondrial import inner membrane translocase subunit TIM23-2
- Mitochondrial import inner membrane translocase subunit TIM17-2
Sequence:
MAGRLLANLIVMGSGIIGRAVFQAYRQALANASKSGVAQEAMQNGVRQAGKAITEQEARQILGVTEKTSWEEILQKYDKLFENNAKAGSFYLQSKVHRAKECLEVVYRSQGNGTPS
Protein: Eukaryotic translation elongation factor 1 epsilon 1 (HCG15559, isoform CRA_d) (D6RBD7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAAAELSLLEKSLGLSKGNKYSAQGERQIPVLQTNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYLTGYNFTLADILLYYGLHRFIVSICIVTGFFSVVLRMIFKTLS
Protein: Mevalonate kinase (MK) (EC 2.7.1.36) (P46086)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21655959}.
Interaction partners:
- Phosphomevalonate kinase, peroxisomal
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Hydroxymethylglutaryl-CoA synthase
- Acetyl-CoA acetyltransferase 2
- Acetyl-CoA acetyltransferase 1
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic
Sequence:
MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEFSWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTGTVVDKVVEELESSGFQCFTALIGGNGAQICY
Protein: Metalloendopeptidase (Q5AEH7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- SUMO family protein
Sequence:
MVKEGHGAFPVPKANDIPPPANIKKIGALKRFSDEAYAKSLLYDAARLVAPIIHEQKFKVGKLYEMYPDKAELWGLNVNHGQKIYLRLREHHNDKSFLPMGDIVGTLLHELTHNLYSAHDSKFYKFLDKLKSRYDDIHCRGAKTKYLCEENKVGRGVLLSGSLVSVREQRLKELSKPKFANESKVLGSNSKINKPIGGSPRDLRQAILEAAERRLRDSKWCHSENAETESVPKEDEYDTTQVELIGPTEGKPVGTFANDIIDLTSDTEETPIQPDNPKRRILHEIIDLTSDTEDIEPTTPEVICID
Protein: BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11) (Q693B1)
Organism: Homo sapiens (Human)
Function: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Interaction partners:
- Cullin-3
- BTB/POZ domain-containing protein KCTD5
- BTB/POZ domain-containing protein KCTD2
Sequence:
MLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH
Protein: Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18) (O95678)
Organism: Homo sapiens (Human)
Function: Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
Interaction partners:
- Keratin, type I cuticular Ha4
Sequence:
MSRQSSITFQSGSRRGFSTTSAITPAAGRSRFSSVSVARSAAGSGGLGRISSAGASFGSRSLYNLGGAKRVSINGCGSSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLGGGSGYSFTTSGGHSLGAGLGGSGFSATSNRGLGGSGSSVKFVSTTSSSQKSYTH
Protein: Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) (P25021)
Organism: Homo sapiens (Human)
Function: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Potassium-transporting ATPase alpha chain 2
- Potassium-transporting ATPase alpha chain 1
- Guanine nucleotide-binding protein G
- Histidine decarboxylase
- Gastrin
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
Protein: High mobility group protein B2 (High mobility group protein 2) (HMG-2) (P26583)
Organism: Homo sapiens (Human)
Function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:12925773, ECO:0000269|PubMed:23877675}. Chromosome {ECO:0000269|PubMed:12925773}. Cytoplasm {ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:23877675}. Secreted {ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:23877675}. Note=In basal state predominantly nuclear. {ECO:0000305}.
Interaction partners:
- High mobility group protein B1
- Nucleolin
- Acidic leucine-rich nuclear phosphoprotein 32 family member A
- Granzyme A
- DNA fragmentation factor subunit beta
- Protein SET
- Homeobox protein PKNOX1
Sequence:
MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE
Protein: Protocadherin gamma A12 (Q8K4A4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
GDSVFSKDNHALNQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNG
Protein: Trypsin inhibitor HSTI (P84712)
Organism: Mesosphaerum suaveolens (Pignut) (Hyptis suaveolens)
Function: Inhibitor of serine proteases. Can inhibit trypsin but is ineffective against chymotrypsin, papain and elastase. Strongly inhibits the trypsin-like protease activity isolated from the third instar larva of P.truncatus, and also inhibits more weakly the trypsin-like protease activity isolated from the third instar larva of M.sexta. Protects the plant by inhibiting proteases of invading organisms.
Interaction partners:
Sequence:
RGWGSDEKKDREEEXEQQ
Protein: Trans-2-enoyl-CoA reductase (NADPH) (A0A1D8PCD8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain
- Very-long-chain
- Elongation of fatty acids protein
- Elongation of fatty acids protein
- Acyl-CoA desaturase
- Acyl-CoA desaturase
- Fad2p
- Polyprenal reductase
- Very-long-chain
Sequence:
MTDIEVKSRSRSIKSFSSNELTPDSSVQELINELSSDNHISEHRLRLTKLENGKQVALIPHKTFAENGIPKTASKIELFVKDLGPQISWRTVFLVEYFGPFIFHPLFYYVQSLYGSGSFEHTQTQKFAFAIVLLHFLKRELETIFVHKFSNATMPAFNIFKNSGHYWILSGFNLAYFIYGPSDKSGVLKYFFHVNELPSSVVYGLFGLWVFAELSNLTTHLILSNLRKGDSKVYVIPFGYGFNWVSCPNYFFESLSWLAYALLVGNWSAWIFLFVSSGQMWLWAVKKHQRYLKSFGDDYKKLKRKIYIPFVI
Protein: Adenosine deaminase domain-containing protein 2 (Q9D5P4)
Organism: Mus musculus (Mouse)
Function: Required for male fertility and normal male germ cell differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:32665638}. Cytoplasm {ECO:0000269|PubMed:32665638}. Note=Diffusely cytoplasmic early in pachytene spermatocytes and coalesces into several perinuclear granules by late pachynema. {ECO:0000269|PubMed:32665638}.
Interaction partners:
Sequence:
MASVDEGGRRRPRLAASLQISPGPWKPSGGQEPTEAGDAAPRTAEHGVAGAQEAHREACKALGGSVLSPGPAGDFPGALHGLSMLPKDPPPAQAVALLTQCMANLGVSLTFLEDQTAGPGSSFSVCADLDGLVCPAGTGSSKLEAKQQAALSALQYIQKQLERPEPLVTPRQPLLTSLSIETILTHEQRCAAVVSAGLDRLLSESSPYQACKGTVAAVILEREVQGSIGHSKETYELVALGTGSSSCAGWLEFSGRRLHDCHGLVIARRALLRFFFRQLLLVTQGGPKGQERSVLTPQPGPGPPFALKPGVFLHLYVSNTPKGAAHDIYLPLASEDSVLHSPAFRLQAHVCGQLKPVSYVAPALRDTHVGCLSASDKLARWAILGLGGGLLAHFLPPLYATSLVLADPCHDPSTLNRVIHSRPRLDSVLGSCLPCPYVRTTLHLFAGPLVAPSDPGPSTCHSLSLNWSLGDPDIEVVDVATGRVKTDSSVGPPSRLCKAAFLSAFRQVARALEKPQLLSLQTYEAAKAVPYREARQQLSLLLDQQGLGAWPSKPLVGKFRH