wanglab/gogpt-training-data huggingface dataset:
Protein: Photosynthetic NDH subunit of subcomplex B 1, chloroplastic (Protein PnsB1) (NAD(P)H DEHYDROGENASE SUBUNIT 48) (NDH-DEPENDENT CYCLIC ELECTRON FLOW 1) (Q9S9N6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18785996, ECO:0000269|PubMed:18974055}; Peripheral membrane protein {ECO:0000269|PubMed:18974055}; Stromal side {ECO:0000269|PubMed:18974055}.
Interaction partners:
- NAD
- Photosynthetic NDH subunit of subcomplex B 3, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 2, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 4, chloroplastic
- NAD
- Photosynthetic NDH subunit of subcomplex B 5, chloroplastic
- NAD
- NAD
- Photosystem I chlorophyll a/b-binding protein 6, chloroplastic
- Photosynthetic NDH subunit of lumenal location 3, chloroplastic
Sequence:
MASSLPLLPKPISPFFKTPPFSTSKPLVFLNFQTRLTSRSSDVSVNLKKKNNPWLDPFDSGEDPDNEYGSLFADGKQDEDPRPPDNPDNPYGFLKFPKGYTVELASLPLKIRGDVRRCCCVISGGVYENLLFFPTIQLIKDRYPGVQVDILTTERGKQTYELNKNVRWANVYDPDDHWPEPAEYTDMIGLLKGRYYDMVLSTKLAGLGHAAFLFMTTARDRVSYIYPNVNSAGAGLMLSETFTAENTNLSELGYSMYTQMEDWLGRPFRSVPRTPLLPLRVSISRKVKEVVAAKYRNAGAVTGKFIVIHGIESDSKASMQSKGDADSLLSLEKWAKIIKGVRGFKPVFVIPHEKERENVEDFVGDDTSIVFITTPGQLAALINDSAGVIATNTAAIQLANARDKPCIGLFSSEEKGKLFVPYAEEKSNCVIIASKTGKLADIDIGTVKNAMQVFEGSLALV
Protein: Photosystem II reaction center W protein, chloroplastic (PSII 6.1 kDa protein) (Q39194)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stabilizes dimeric photosystem II (PSII). In its absence no dimeric PSII accumulates and there is a reduction of monomeric PSII.
Subcellular location: Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=The N-terminus is found within the thylakoid lumen (By similarity). {ECO:0000250|UniProtKB:Q41387}.
Interaction partners:
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Expressed protein
- Photosystem II 5 kDa protein, chloroplastic
- Chlorophyll a-b binding protein CP26, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem II CP43 reaction center protein
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem II reaction center protein I
- Chlorophyll a-b binding protein
Sequence:
MASFTASASTVSAARPALLLKPTVAISAPVLGLPPMGKKKGGVRCSMETKQGNVSVMGAGVSAAATAALTAVMSNPAMALVDERMSTEGTGLPFGLSNNLLGWILFGVFGLIWTFFFVYTSSLEEDEESGLSL
Protein: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B (Q66HV9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Reticulon 4 receptor.
- Reticulon
- Myelin-associated glycoprotein
Sequence:
MTFLQVTIKMVAREASGHSYLVACWQPILILMLGTVLSGSATGCPSRCECSAQERSVVCHRRKLITLPEGIPIDTRLLDLSKNRLKAINPEEFLNYPQLEDLQLNENIISVIEPGAFSNLLGLRTLGLRNNNLKLIQLGVFTGLSNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRAFHGLSSLEQLTMERCNLTSVPTEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESLTAKSLHGLNITTLSITNCNLTAVPYVAIQHLVYLRFFNLSFNPIEVVEGNKMHNLLRLQAFHLVGGRLVSIEPYSFKGLNYLRVLNVSSNSLSTLEESAFHSVGNLETLALHDNPLACDCRLLWVFRRRWRLNFNRQQPSCETPEFLQGKEFKDFPDVLPPNYFTCQKSKIRDHKAIHRFVDEGTTVQFPCQADGDPTPMIMWQSPKKQFITTKSIGRLSVSLDGTLEVRYAQIQDNGTYTCFAVNAGGNDTRLAHLHVHSYSPNWPHQPNKTFAFILNQPSDNSANGTGAMDPFPFDMKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNAKPNIEIEYVPRKVDGENSPNEGSHKISMKMI
Protein: Tumor necrosis factor ligand superfamily member 13B (B-cell-activating factor) (BAFF) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form] (Q9WU72)
Organism: Mus musculus (Mouse)
Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Subcellular location: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 17
- Tumor necrosis factor receptor superfamily member 13C
- Tumor necrosis factor receptor superfamily member 13B
- Tumor necrosis factor receptor superfamily member 5
- CD40 ligand
- Tumor necrosis factor ligand superfamily member 12
- Tumor necrosis factor ligand superfamily member 11
- TNF receptor-associated factor 3
- Tumor necrosis factor
- Lymphotoxin-beta
Sequence:
MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICRDGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELTAGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNGMNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIARLEEGDEIQLAIPRENAQISRNGDDTFFGALKLL
Protein: Elongation factor 1-alpha 1 (EF-1-alpha 1) (P0CY35)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Cam1-1p
- Tef4p
- Translation elongation factor EF1B gamma
- Translation elongation factor 1 subunit beta
- Transcription factor SKN7
- GTP-binding nuclear protein
- Elongation factor 3
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL4
Sequence:
MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYHVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDSVKWDKNRFEEIIKETSNFVKKVGYNPKTVPFVPISGWNGDNMIEPSTNCPWYKGWEKETKSGKVTGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPAGVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKNDPPKGCDSFNAQVIVLNHPGQISAGYSPVLDCHTAHIACKFDTLVEKIDRRTGKKLEENPKFVKSGDAAIVKMVPTKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKSDKAGKVTKAAQKAAKK
Protein: B-cell activating factor (TNF superfamily member 13b) (Tumor necrosis factor ligand 7A) (B0LKN7)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- TNF receptor superfamily member 17
- TNF receptor superfamily member 13C
- Tumor necrosis factor receptor superfamily member 13B
- CD40 ligand
- Lymphotoxin-beta
- Tumor necrosis factor receptor superfamily member 5
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member
- LTBR protein
- CD40 ligand
Sequence:
MDDSTGEQSRLSCPQTREEMKLKEGGSVLPQEESPSGRCSKDGKLLAVTLLLAASSSCLTVLAFCWVASLQAELGSLRAELRGRPGAPQAGAAAPREAPGVTPALKQRIFAPPAPGESNSSQSGRSKRALQEAEETVTQDCLQLIADSDTPTIRKGAYTFVPWLLSFKRGRALEEKENKILVKETGYFFIYGQVLYTDNTFAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPREDAKISRDGDGTFFGALKLL
Protein: Tropomyosin alpha-4 chain (Tropomyosin-4) (TM-4) (P09495)
Organism: Rattus norvegicus (Rat)
Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (By similarity). Smooth muscle contraction is regulated by interaction with caldesmon (By similarity). In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7568216}. Note=Associates with F-actin stress fibers (PubMed:7568216). {ECO:0000269|PubMed:7568216}.
Interaction partners:
- Troponin T, cardiac muscle
- Troponin I, cardiac muscle
- Actin, alpha cardiac muscle 1
- Troponin T, fast skeletal muscle
- Myosin light chain 1/3, skeletal muscle isoform
- Troponin T, slow skeletal muscle
- Myosin light polypeptide 6
- Troponin C, skeletal muscle
- RCG25684, isoform CRA_a.
- Troponin I, slow skeletal muscle
Sequence:
MAGLNSLEAVKRKIQALQQQADDAEDRAQGLQRELDGERERREKAEGDAAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKSSDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI
Protein: NFE2 (Nuclear factor protein) (Transcription factor NF-E2 45 kDa subunit) (Q7ZZR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDLAWQELMAITELQEFEEPNENPFEAIPYLSMEPMVSQGGFGMNQPQPESIPATCDAHPSGVYESAYPEMMPPYPHMDMHYGLPGGHGSSRMLANTQGFHPPLMSLLEHMNMTTRGHGIAKDGIINFHSTGQIKQVCTDDLESDSGLSLGSSPPLASPENAVHGVPAYLPTDISTGYAESESIGEQCRLRPNLHGAVDYQQSYSSYPGASFPASANMPSSNLHTYSPVASIKQPVLPTALHDLQLNSSRVGSYQSPYPKCKSSSVPVPLSRDERRALALKIPFSLEKIVNLPVDDFNELLTQFTLTDAQLALVRDIRRRGKNKVAAQNCRKRKLENIVHLESELGQLRAQREHLARERLEFQQNIAIIKCRLSDLHTQVFSQLHDEEGHPYSVDEYSLQQTNDGNIYLVPRNAALAGE
Protein: tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) (Q84K50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- tRNA
- Putative tRNA
- tRNA
- tRNA
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Periodic tryptophan protein 2
- Probable RNA 3'-terminal phosphate cyclase-like protein
- Ribosome biogenesis protein BOP1 homolog
- tRNA
- tRNA
Sequence:
MLPTESKKAFSFKRCIEDGDLVIVYERHDVMKPVKVSKDGVLQNRFGVYKHSDWIGKPLGTKVFSNKGKFVYLLAPTPELWTLVLSHRTQILYIADISFVVMYLEVVPGCVVLESGTGSGSLSTSLARAVAPTGHVYSFDFHEQRAVSAREDFEKTGISSLVTVEVRDIQGEGFPEKLSGLADSVFLDLPQPWLAVPSAAKMLKQDGVLCSFSPCIEQVQRTCEVLRSDFIEIRTFEVLLRTYEVKEVKMDTSSMVGESHEEDNEGMRPCKRKHRSNENDTVSQDNSSNASSVVMARPCSEARGHTGYLTFARLQCLA
Protein: Histone H2A.V (H2A.F/Z) (Q27511)
Organism: Caenorhabditis elegans
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22.
Subcellular location: Nucleus {ECO:0000269|PubMed:24346701}. Chromosome {ECO:0000250|UniProtKB:P27661}. Note=Localizes in punctate structures in the nucleus. {ECO:0000269|PubMed:24346701}.
Interaction partners:
- Helicase ssl-1
- Nucleosome assembly protein 1-like 1
- Vacuolar protein sorting-associated protein 72 homolog
- HIT-type domain-containing protein
- RuvB-like 1
- Mortality factor related protein 1
- Actin-like protein C08B11.6
- DNA methyltransferase 1-associated protein 1
- FACT complex subunit spt-16
- RuvB-like 2
Sequence:
MAGGKGKAGKDSGKSKSKVVSRSARAGLQFPVGRIHRFLKQRTTSSGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLHLAIRGDEELDTLIKATIAGGGVIPHIHRYLMNKKGAPVPGKPGAPGQGPQ
Protein: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Q8IQA7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNERMSAVSEHSSVVCSPEQMAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEVINDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAKNAVAAK
Protein: Eif4g2 protein (Eukaryotic translation initiation factor 4, gamma 2) (Q5BJU2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEAVVTEYLNSGNANDAVSGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
Protein: Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) (P02787)
Organism: Homo sapiens (Human)
Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Subcellular location: Secreted.
Interaction partners:
- Transferrin receptor protein 1
- Apolipoprotein A-I
- Albumin
- Alpha-2-HS-glycoprotein
- Hemopexin
- Alpha-1-antitrypsin
- Transferrin receptor protein 2
- Ceruloplasmin
- Alpha-2-macroglobulin
- Transthyretin
Sequence:
MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP
Protein: Chaperone protein ClpB (P9WPD1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Chaperone protein DnaK
- Protein GrpE
- Chaperone protein DnaJ 1
- ATP-dependent Clp protease proteolytic subunit 1
- ATP-dependent Clp protease proteolytic subunit 2
- Heat shock protein Hsp
- Chaperone protein DnaJ 2
- Co-chaperonin GroES
- Chaperone protein HtpG
- ATP-dependent Clp protease adapter protein ClpS
Sequence:
MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDGIAAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELDDEYVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQALQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEYRKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELTTRWQNEKNAIEIVRDLKEQLEALRGESERAERDGDLAKAAELRYGRIPEVEKKLDAALPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMEDELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDPVYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG
Protein: Deoxycytidine kinase 2 (XldCK2) (EC 2.7.1.74) (Deoxyadenosine kinase 2) (EC 2.7.1.76) (Deoxyguanosine kinase 2) (EC 2.7.1.113) (Q6DD33)
Organism: Xenopus laevis (African clawed frog)
Function: Phosphorylates the deoxyribonucleosides deoxyadenosine, deoxycytidine and deoxyguanosine with highest activity against deoxyguanosine followed by deadenosine and then deoxycytidine. Shows only very minor activity against deoxyuridine and deoxythymidine.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P27707}.
Interaction partners:
Sequence:
MATPPKRMCHSPVFNNSFEKRVKKLSIEGNIAAGKSTFVRILEKASDEWEVVPEPIAKWCNVQTTENENEELSTSQKSGGNLLQMLYDKPTRWAYTFQTYACLSRVRAQLKTPSPKLLEAEHPVQFFERSVYSDRYIFASSLFEFQNINETEWAIYQDWHTWFLNQFESDIDLDGIIYLRATPEKCMDRLHTRGREEEQGIQLEYLESLHYKHESWLYDRTMSVDFENLQHMPVMVLDVNEDFKYDKIKQEALLDKVKEFLASL
Protein: SUMO specific peptidase 6 (H0Y4F4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
LSNNKKLSENTQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRLQGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQTNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKRRKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDFYLK
Protein: Isotocin receptor-like 2 (Oxytocin receptor) (E4W699)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
Interaction partners:
- Oxytocin
- Isotocin receptor-like 1
- Arginine vasopressin
- Guanine nucleotide-binding protein subunit alpha
Sequence:
MEDIFKDQDFWSFNESSRNATNETYGVNQTVNPLKRNEEVAKVEVTVLALVLFLALAGNLCVLIAIHTAKHSQSRMYYFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDILCRLVKYLQTVGMFASTYMLVLMSIDRCMAICQPLRSLHKRKDRCYVICSWALSLLFSIPQVYIFSLREVGSGVYDCWGDFVQPWGAKAYITWISLTIYIIPVTILSVCYGLISFKIWQNFKRKTKRDQCITLTPKASKGNALARVSSVKLISKAKITTVKMTFVIVLAYIVCWTPFFSVQMWSAWDPEAPREAMPFIISMLLASLNSCCNPWIYMFFAGHLFHDLKQNLFCCSTLYLKSSQCRYDPEQDSRKSNSSTYVIKSTSSQRSITQTSIT
Protein: Sp3 transcription factor (H0Y7L6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQTGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
Protein: Patatin-like protein 6 (AtPLP6) (EC 3.1.1.-) (Patatin-related phospholipase A IIIalpha) (pPLAIIIa) (Phospholipase A IIB) (AtPLAIIB) (O80959)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance (By similarity).
Interaction partners:
- Peroxisome biogenesis protein 19-2
- Peroxisome biogenesis protein 19-1
- ARM repeat superfamily protein
- Phosphatidylglycerophosphate phosphatase 1, chloroplastic/mitochondrial
- ARM repeat superfamily protein
- WAT1-related protein At4g28040
- Vesicle-associated protein 2-2
- Phospholipase A I
- Phospholipase SGR2
Sequence:
MLTTMQRVHNKPIDSIGGFKHLVKQSNGGDGGVTATDMQEPSIETDKLSYEIFSILESKFLFGYDDDLKLMESRSRDPSPEQETASPAMVEALNGVVPGTVKNQRGKVCVLSIDSGGMRGIIPGKALAYLEHALKSKSGDPNARIADYFDVASGSGIGGIFTAMLFASSDGNRPIFKAEDTWRFLAMKGKSFYNKSPPGILNRVMKTGSGGSGGSGSKLEKAMKESFEELTLKDTLKPVLIPCYDLTSSAPFLFSRADALETDGYDFKLWEVCRATWAEPGVFEPVEMRSVDGKTRCVAVDGGLAMSNPTAAAITHVLHNKQEFPFVRGVEDLLVLSLGTGQLVDVKYDCDKVMKWKAKHWARPAVRISADGAADTVDQAVSMAFGQCRRSNYVRIQANGSSFGPCKPNIDTDASPSNVNMLVGVAEEMLKQKNAESVLFGGKKINEESNYEKLDWLAGELVLEHQRRSCRIAPTVAFKQSGDRRVDQQTIFKDIDCMF
Protein: E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) (O54965)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation (By similarity). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity). Also involved in protein trafficking and localization (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:19292867}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:19292867}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000269|PubMed:20230530}; Single-pass type I membrane protein {ECO:0000255}. Note=The mature protein is subjected to extensive proteolysis that leads to the shedding of the ectodomain into the lumen of vesicles and the release of the C-terminal fragment into the cytosol (PubMed:20230530). Not detected in early endosomes (PubMed:20230530). Treatment of the cells with either PMA or ionomycin stabilizes the full-length protein which relocalizes to recycling endosomes and to the inner nuclear membrane (PubMed:20230530). {ECO:0000269|PubMed:20230530}.
Interaction partners:
Sequence:
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFEDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPLKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDTLKKIDIPSVFIGESSANSLKDEFTYEKGGHIILVPELSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRNRRNRLRKDQLKKLPVHKFKKGDEYDVCAICLEEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENQVSEHTPLLPPSASARTQSFGSLSESHSHHNMTESSDYEDDDNEETDSSDADNEITDHSVVVQLQPNGEQDYNIANTV
Protein: Falz protein (B1H2A3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAQVVQANAAAGPTPSVPAPVPAPAPAPAAPPAPPSPPPSTHSLPPAGHPTAPLPVTSQKRKREEEKDSKSKKKKMISTTSKEAKKDTRLYCICKTPYDESKFYIGCDLCTNWYHGDCVGITEKEAKKMDVYICNDCKRAQEGSSEELYCICRTPYDESQFYIGCDRCQNWFHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERIQKRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRSHNNKLQSTAP
Protein: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (A0A8I6G861)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAGNVKKSSGAGGSGSGGSGAGGLIGLMKDAFQPHHHHHHHLSPHPPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKASSSSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGTETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSTTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPVPKLPPGEQGDSEEDTEYMTPTSRPVGVQKPEPKRPAETAQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSACGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGEPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGAMANPAAAAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT