wanglab/gogpt-training-data huggingface dataset:
Protein: COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) (Q9BT78)
Organism: Homo sapiens (Human)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}.
Interaction partners:
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 7b
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 7a
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 3
- E3 ubiquitin-protein ligase RBX1
- Ubiquitin-like protein NEDD8
Sequence:
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
Protein: Cytochrome c oxidase subunit 6, mitochondrial (Cytochrome c oxidase polypeptide VI) (P00427)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX6 may stabilize the region of CIV at the interface with CIII, supporting a role in formation or stability of the CIII(2)IV(2) SC.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30598554}; Peripheral membrane protein {ECO:0000269|PubMed:30598554}; Matrix side {ECO:0000269|PubMed:30598554}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 9, mitochondrial
- Cytochrome c oxidase subunit 7, mitochondrial
- Cytochrome c oxidase subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 13, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome b-c1 complex subunit 2, mitochondrial
Sequence:
MLSRAIFRNPVINRTLLRARPGAYHATRLTKNTFIQSRKYSDAHDEETFEEFTARYEKEFDEAYDLFEVQRVLNNCFSYDLVPAPAVIEKALRAARRVNDLPTAIRVFEALKYKVENEDQYKAYLDELKDVRQELGVPLKEELFPSSS
Protein: EG:BACN32G11.3 protein (Leucine-rich pentatricopeptide repeat containing 2) (Q9W592)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO11133p1
- NADH dehydrogenase complex I, assembly factor 6 homolog
Sequence:
MQRARLLRNVWLCRQRLGHLPGRSASSASLAFRYATKPAAPAVPFSLLQMRSLGTGGVLSAVERRSRRPASSSEKPKASVADAWTQLEAYYRQHDLINFEHCQRLLELLQESASPLGVGIEEVHFLLGSCVPELLPAQSSQERLQLFKGLWAQLIKLGQPTLAHYHTKLQVLRQNRLPLTDYRSLLAEIAVYHGAADSTLYGALLDVAGAAGNMRMATEILSEMRERSLALTEHNFHALLLGHARSGDLPGAESVLASMRAAGIQQGSSTQAIWFEALLENGQLAQAKELLQVEHGFTAPQLLQMLRGLLASKDVDTDLIQLLVKELPREFLTGIDLPPAIRSLCIQLVHQGRTEVVIQLVGALPAPKFELQNQNVDEYGALLLQEFFRAQVPLDQTIQFAGQLVQRNQNVRALHLVAELALRRQPSSALRCLEDLSAAGEELRPHYFWPLILHHYRREGESGMLRLVSEMRRLRVECDEETLRHYLFPHLRQTLVQPLEAVKALESAGVKPSQTLCPVVSHLLQQHQMSEVLDLLDRYPTRLDLATLLQPLSSLAVNARATKRFEVFAKVIQALQQKALKRGEDFVGSLLLQMTGPQTRLRQDATSLRRFLHELRRLELQISPAASEALLSVVRHATDDVDLIQDLAKTLQKMKNPQLALPADTVSLHGGFIKHPRDMSIDELECHLVELESKQLNPRGVLRRLLQLSVRSGRLERAQQLLAKCQVLKVQESAGMMASIFDLHIKLRDLPRAQESLERLSSMYPAFQIDEHKVIDYAALLVQGQQLEAAKQLLQRRAEQHKVVGGDYVMKNVWQLLTNVGQLAASSHAGGESSKQLNQTREWLDFLRGLGYCQSQNALLGPVVREWLLKGNLDAAVAEFQRLANTHKHTPLQFELLSLLVRLGNGDEQELTRFPGVTAESAQQHLAVVTATVSRIHGAANMNSALLLALAESGKETQLRRLIINPEFRINHELLVKNCEHLGQEGAVRTLLRLARGVRGVQRTIDEQKIYDLLLAQFCRSNDYEAALDLFERLEADDELKVSHEFLRNLVQLLQVNQVEIPSTIALRAHVR
Protein: exopolyphosphatase (EC 3.6.1.11) (A0A0K6LY49)
Organism: Bacillus cereus
Interaction partners:
Sequence:
MKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQLHHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEARYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSFPFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMKEEDIKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNVVEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGMMHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIVCEQSALAEKVQAEKQKKQLERVLKTNIILLFKLKN
Protein: Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH9 (EC 3.6.4.13) (DEAH RNA helicase homolog DDX35) (F4JRJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in pre-mRNA splicing.
Interaction partners:
- DEAD-box ATP-dependent RNA helicase 56
- DEAD-box ATP-dependent RNA helicase 35
- DEAD-box ATP-dependent RNA helicase 15
- DEAD-box ATP-dependent RNA helicase 28
- At1g31870
- Chloroplastic group IIB intron splicing facilitator CRS2-A, chloroplastic
- Peptidyl-tRNA hydrolase, chloroplastic
- Chloroplastic group IIB intron splicing facilitator CRS2-B, chloroplastic
- AT3g15090/K15M2_24
- DEAD-box ATP-dependent RNA helicase 36
Sequence:
MAFWKPGTEKPRFEEDGEGGIVFMSNNLASSSSSSYGYANIEKQRQRLPVYKYRTEILYLVENHATTIIVGETGSGKTTQIPQYLKEAGWAEGGRVIACTQPRRLAVQAVSARVAEEMGVNLGEEVGYTIRFEDHTTSGVTSVKFLTDGVLIREMMEDPLLTKYSVIMIDEAHERSISTDILLGLLKKIQRRRPELRLIISSATIEAKTMSNFFNSSKKRHAPEGSTPGPKLEPAILSVEGRGFSVKIHYVEEPVSDYIRSVVSTILLINEREPPGDVLVFLTGQEDIETAIKLLEEEAHSNQKNSSGLLPLPLYSGLSRSEQELIFTPTPRGKRKVILSTNIAETSLTLEGVVYVIDSGFSKQKFYNPISDIESLVVAPISKASARQRSGRAGRVRPGKCYRLYTEDYFLNQMPGEGIPEMQRSNLVSTVIQLKALGIDNILGFDWPAPPSSEAMIRALEVLYSLQILDDDAKLTSPTGFQVAELPLDPMISKMILASSELGCSHEIITIAAVLSVQSVWIIARGVQKEQDEAKLRFAAAEGDHVTFLNVYKGFLESKKPTQWCYKNFLNYQSMKKVVEIRDQLKRIARRLGITLKSCDGDMEAVRKAVTAGFFANACRLEPHSNGVYKTIRGSEEVYIHPSSVLFRVNPKWVVYQSIVSTERQYMRNVVTINPSWLTEVAPHFYQNRQNAMSF
Protein: Contactin-1 (Neural cell surface protein F3) (Q63198)
Organism: Rattus norvegicus (Rat)
Function: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Contactin-associated protein 1
- Neurofascin
- Receptor-type tyrosine-protein phosphatase zeta
- Neurogenic locus notch homolog protein 2
- Major prion protein
- Receptor-type tyrosine-protein phosphatase gamma
- Hyaluronan and proteoglycan link protein 2
- Neuronal cell adhesion molecule
Sequence:
MKTPLLVSHLLLISLTSCLGEFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTNDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEDRPEVKVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDIYTMMGQNVTLECFALGNPVPDIRWRKVLEPMPTTAEISTSGAVLKIFNIQLEDEGLYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENAYGTIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITNPTRIILAPINADITVGENATMQCAASFDPSLDLTFVWSFNGYVIDFNKEITNIHYQRNFMLDANGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMESAKAVDLIPWMEYEFRVVATNTLGTGEPSIPSNRIKTDGAAPNVAPSDVGGGGGTNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGDGPYSLIAVINSAQDAPSEAPTEVGVKVLSSSEISVHWKHVLEKIVESYQIRYWAGHDKEAAAHRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKILYRPDGQHDGKLFSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGVSTLSSGLLSLLLPSLGFLVFYSEF
Protein: Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (Mitsugumin-33A) (Transmembrane protein 38A) (A5A6S6)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:17611541}; Multi-pass membrane protein {ECO:0000269|PubMed:17611541}. Nucleus membrane {ECO:0000269|PubMed:17611541}.
Interaction partners:
Sequence:
MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPVASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFIMIATGWVKGSGVALLSNVEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTMFMVSCKVFLTATHSHSSPFDVLEAYVCPVLFGTGSGGDHPQDNHGAWPGGPPSGALATKSKEELSEGSRKKKTKKAD
Protein: Histone deacetylase 6 (D3ZVD8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Runt-related transcription factor 2
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- Ataxin-3
- NAD-dependent protein deacetylase sirtuin-2
- Transitional endoplasmic reticulum ATPase
- Sequestosome-1
- Histone deacetylase 11
- Alpha-tubulin N-acetyltransferase 1
- NAD-dependent protein deacetylase sirtuin-1
Sequence:
MRARGHTGRREFGGASQGRSLERGQCSSRSRSKGSSAMTSTGQDSSTRQRKSRHNPQSPLQDSSATLKRGGKKGAVPHSSPNLAEVKKKGKMKKLSQPAEEDLIVGLQGLDLNSETRVPVGTGLVFDEQLNDFHCLWDDSFPENPERLHAIKEQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAGTYDSVYLHPNSYSCACLATGSVLRLVDAVMGAEIRNGMAVIRPPGHHAQRSLMDGYCMFNHLAVAARYAQKKHRIQRILIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHILLPVAFEFQPQLVLVAAGFDALHGDPKGEMSATPAGFAHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGDPCPMLESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLEDEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRDLHREGANFESIYICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQVIAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSLRPPQSGALASISEVIQVHRKYWRSLRLMKMEDKEERSSSRLVIKKLPQSASPVSAKGMTTPKGKVLEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTDQCASVAATENSANQTTSGEEASGETESFGTSPSSNASKQTTGASPLHGAAAQQSPELGLSSTLELSSEAQEVQESEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGSVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYLCQAYVHHEDLQDVKNAAHQNKFGEGMPHLQ
Protein: DIBOA-glucoside dioxygenase BX6 (EC 1.14.11.59) (2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase) (2-oxoglutarate-dependent dioxygenase BX6) (Protein BENZOXAZINONE SYNTHESIS 6) (Q84TC2)
Organism: Zea mays (Maize)
Function: 2-oxoglutarate-dependent dioxygenase required for hydroxylation in position C-7 of the benzoxazinoids. Can use 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside (DIBOA-glucoside) as substrate, but not aglucone DIBOA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18192444}.
Interaction partners:
- O-methyltransferase ZRP4
- Glycosyltransferase
- DIMBOA UDP-glucosyltransferase BX9-one 2-D-glucosyltransferase BX9)
- UDP-glycosyltransferase 76C1
- Indole-3-glycerol phosphate lyase, chloroplastic
- indole-2-monooxygenase
- DIMBOA UDP-glucosyltransferase BX8-one 2-D-glucosyltransferase BX8)
- Benzoxazinone synthesis2
- TRIBOA-glucoside O-methyltransferase BX7
- Cytochrome P450 71C3
Sequence:
MAPTTATKDDSGYGDERRRELQAFDDTKLGVKGLVDSGVKSIPSIFHHPPEALSDIISPAPLPSSPPSGAAIPVVDLSVTRREDLVEQVRHAAGTVGFFWLVNHGVAEELMGGMLRGVRQFNEGPVEAKQALYSRDLARNLRFASNFDLFKAAAADWRDTLFCEVAPNPPPREELPEPLRNVMLEYGAAVTKLARFVFELLSESLGMPSDHLYEMECMQNLNVVCQYYPPCPEPHRTVGVKRHTDPGFFTILLQDGMGGLQVRLGNNGQSGGCWVDIAPRPGALMVNIGDLLQLVTNDRFRSVEHRVPANKSSDTARVSVASFFNTDVRRSERMYGPIPDPSKPPLYRSVRARDFIAKFNTIGLDGRALDHFRL
Protein: Formate-nitrite transporter (PfFNT) (Lactate/H(+) symporter) (Lactate/H(+) transporter) (O77389)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cell membrane {ECO:0000269|PubMed:25669138, ECO:0000269|PubMed:25823844}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:25823844}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
- NADH-cytochrome b5 reductase, putative
- Nodulation protein E
- Adrenodoxin-type ferredoxin, putative
- Ferredoxin, apicoplast
Sequence:
MPPNNSKYVLDPVSIKSVCGGEESYIRCVEYGKKKAHYSNLNLLAKAILAGMFVGLCAHASGIAGGLFYYHKLREIVGASMSVFVYGFTFPIAFMCIICTGSDLFTGNTLAVTMALYEKKVKLLDYLRVMTISLFGNYVGAVSFAFFVSYLSGAFTNVHAVEKNHFFQFLNDIAEKKVHHTFVECVSLAVGCNIFVCLAVYFVLTLKDGAGYVFSVFFAVYAFAIAGYEHIIANIYTLNIALMVNTKITVYQAYIKNLLPTLLGNYIAGAIVLGLPLYFIYKEHYYNFERSKRDNNDAQMKSLSIELRN
Protein: Schizo, isoform D (E1JI59)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSYTAAQYYKTTNMITSNEIYCFPQKSLERSGSTQYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYAPGAHSSSAAINYPAQQHPQMVYQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHYMQVTATGGGQYHHHHMLHGHGHHAHHHGGAVVIAGSGVGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGGDVLKRTRAQSAYELSQDLLEKQIELLERKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAIAAAANAAAAAKMRFNMPPTAAIATPSNVYAAPGMQAYTHANFVQQSQAAYMLQQQQMLQQQAQMQAQAQAQAQAQAQAQAQAQAQAQAQPLTGRIPGRERKASRTDENGRSTEV
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (Q8IHY0)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
- Phosphatidylinositol 4-phosphate 5-kinase
Sequence:
MGAYLSSPKTNKESLDGGNLELDPSRYGLSCMQGWRKNMEDAHICYNNLKFNEIEEDVSIYGVFDGHGGPNVSKWISYNFRRIFIRCLKEANEEMIKKNMKRSENYKLKLIKLTLEKTFLKLDEEMLLSENQEKLKKYSVPTQEDEEESDTRENYIYSILNDIISKNISIKAIEKDGKRCLQVVYNKDGSPVEEGNTDGSATSTLNQDQPEHNQLYEDGNDNNNSNNNNNNNNNNISPNLYGTNGENILRSDENYDSSNLNLGDNQDRKNYDDIENLGDNNNSSNDMLKKDDASSDILTATTSTNDMKDEDKKNNYLVEKNEHMKKENNNCEENSEQNKQVNGMSSYNKALIEGAMGESIDEKGLLNLNDIKTNNILIDNNNDSNNNNNNNNNNNNSSSNDPSMFSTAYAHHCNNNEGTIGDYLNNEENNETNNIKRLKKDICNDEKGNTQNDIKEEDKMRNMETYMNEPIDGVKSELTYDNLKSMEEQEKNGEIEQGINNMIDHFQSNNLLNNDNTNGNINSYTNDDIHNNGSLQGYEQDGLIQNRNNGDEVNNSDIERLAYDEASANVIDNNINNDIHEEDEDDENNNNDEETGEDDCNGVYSSEELRLFENYYSNDYEDNIAYSCGSTALVAVILKGYLIVANAGDSRAIVCFNGNSLGMSTDHKPHLQTEEARIKKAGGYIANGRVDGNLNLTRAIGDLHYKRDPFLPQKDQKISAFPEITCVTLTPEDEFLFLACDGIWDCKDGQDVVGFVKTRLEKFEEIPDDPNNSLDNTENSEHMNTNNNSDQNEKLKSEDQNNINNEQENILNTSNNDFQKNENLLNENNMDNINMQEKSETEEDLDLERDEDKHDAPPVIERKKYEKFNKLSQICEELCDECLSNNYKENDGIGCDNMTCLIVQYNPEYKIHTEKKFLNIDDIE
Protein: FLJ00095 protein (Q8TET0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}.
Interaction partners:
Sequence:
FKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFVFCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQSDEREATDTPIVIQPASATETTQLTADSHPSYHTDGFN
Protein: Lymphotoxin beta receptor (F5H2E7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
Protein: Leucine-rich repeat protein kinase family protein (Leucine-rich repeat receptor-like protein kinase) (Putative receptor-like protein kinase) (O22178)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Alpha/beta-Hydrolases superfamily protein
- At1g04210
- Cysteine-rich repeat secretory protein 59
- Outer envelope protein 64, mitochondrial
- Outer envelope membrane protein 7
- Alpha-1,3/1,6-mannosyltransferase ALG2
- Probable protein phosphatase 2C 61
- Pectin lyase-like superfamily protein
- RING-H2 finger protein ATL80
- Ubiquitin-conjugating enzyme E2 32
Sequence:
MKTQSASPFFFVSFFFFFFFFSSLFLLSSALNSDGVLLLSFKYSVLLDPLSLLQSWNYDHDNPCSWRGVLCNNDSRVVTLSLPNSNLVGSIPSDLGFLQNLQSLNLSNNSLNGSLPVEFFAADKLRFLDLSNNLISGEIPVSIGGLHNLQTLNLSDNIFTGKLPANLASLGSLTEVSLKNNYFSGEFPGGGWRSVQYLDISSNLINGSLPPDFSGDNLRYLNVSYNQISGEIPPNVGAGFPQNATVDFSFNNLTGSIPDSPVYLNQKSISFSGNPGLCGGPTRNPCPIPSSPATVSPPTSTPALAAIPKSIGSNRETEPNNNSNPRTGLRPGVIIGIIVGDIAGIGILALIFFYVYKYKNNKTVEKKNNHSLEAHEAKDTTSLSPSSSTTTSSSSPEQSSRFAKWSCLRKNQETDETEEEDEENQRSGEIGENKKGTLVTIDGGEKELEVETLLKASAYILGATGSSIMYKTVLEDGTVLAVRRLGENGLSQQRRFKDFEAHIRAIGKLVHPNLVRLRGFYWGTDEKLVIYDFVPNGSLVNARYRKGGSSPCHLPWETRLKIVKGLARGLAYLHDKKHVHGNLKPSNILLGQDMEPKIGDFGLERLLAGDTSYNRASGSSRIFSSKRLTASSREFGTIGPTPSPSPSSVGPISPYCAPESLRNLKPNPKWDVFGFGVILLELLTGKIVSIDEVGVGNGLTVEDGNRALIMADVAIRSELEGKEDFLLGLFKLGYSCASQIPQKRPTMKEALVVFERYPISSSAKSPSYHYGHY
Protein: Ankyrin 2 (A0A5F9ZH99)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MNGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Protein: Toll-like receptor 6 (Q9VUN0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Toll-related receptor which binds to the neurotrophin spz5. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation. Promotes heterophilic cell adhesion with 18w in vitro. May be an upstream component of the NF-kappa-B (rel) regulatory cascade.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Protein spaetzle 5
- Protein slit
- Neurotrophin 1
- LD20892p
- Protein spaetzle
- Dally-like, isoform A
- Dystroglycan 1
Sequence:
MIYYMLLILPVVLAQDQQHTTESLSTKHHQQQQLSHSNAIMGEAGVSNSQLMQPSTPARTLRPLTAGAGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQQIRNNANCECVNLGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSCIGDDELLCSCGGGGGIGVNLLESGTQSSVTMSSSSNNSRQPELTHYESNLSLNDDEDEDHDQQKNLWA
Protein: CRISPR system Cascade subunit CasD (Q46898)
Organism: Escherichia coli (strain K12)
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Interaction partners:
- CRISPR system Cascade subunit CasA
- CRISPR system Cascade subunit CasB
- CRISPR system Cascade subunit CasE
- CRISPR system Cascade subunit CasC
- CRISPR-associated endonuclease/helicase Cas3
- CRISPR-associated endoribonuclease Cas2
- CRISPR-associated endonuclease Cas1
- Crossover junction endodeoxyribonuclease RuvC
Sequence:
MRSYLILRLAGPMQAWGQPTFEGTRPTGRFPTRSGLLGLLGACLGIQRDDTSSLQALSESVQFAVRCDELILDDRRVSVTGLRDYHTVLGAREDYRGLKSHETIQTWREYLCDASFTVALWLTPHATMVISELEKAVLKPRYTPYLGRRSCPLTHPLFLGTCQASDPQKALLNYEPVGGDIYSEESVTGHHLKFTARDEPMITLPRQFASREWYVIKGGMDVSQ