wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q57X33)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein MAK16 homolog
- Ribosome biogenesis protein, putative
- RNA processing factor 1, putative
- Ribosome biogenesis protein NSA1
- Ribosome biogenesis protein BOP1 homolog
- Pescadillo homolog
- Nucleolar GTP-binding protein 1
- RNA-binding protein, putative
- rRNA processing protein, putative
- Ribosome assembly factor mrt4
Sequence:
MKIKKKDLRKGEAQLPINYPDPIVEQPQETFDEREAQVEQLCKRLAHNEVVVRDEALAQVPPYVQRATAHLLTVEANVDKGALCCFFDMQRKRRGDHRHKSKELSINVLRELDAFRSCEENARREQRRNEAIQRLQRQQREEENDAGANGANDDSSQTRSQTKNSEIGKRSDDHKSVRQIYREWISQWAEVEILLLKLSRGLFFCLWHSDKPLVQLECAQNIARVIHSPHTNSGKLLWFSCMMRVLAKEWRTMDRYRSDKYLAFVRKLMFELFTLMKKWENESQLEQRRVKPSEGGEKSQLNTQERPGTNDGYSDRGSERGSSDRMDNITSCQPLCRALEEACYIFQQQVVPEPSAVGLTMHICDIFFDELCRSEVSSTLFIALGDRIALHAMSKGDFVEKRALDYFIAPIAGGVLETRLREQHGRRQQQWSGGKDTTKSSGSQMVTRPTSRKRARDDDSTNPGNGKAQLAPDVAAAREAHLIITALADCCRRYSVSRGTFYSVRPMFAESEMALRQAADASNFVELTGKELRCRLEREVEEVDTTRAAFAGQRKKARLLKQREGRKPPTSKRKVHMIDGGSKKVSKRDRGHEVLKRQKKEVPRNTKRKKNYQLTVEDLYGDE
Protein: Kinesin-like protein (Q4QGE1)
Organism: Leishmania major
Interaction partners:
Sequence:
MRAESSGSESQSRQSERTCGVSPGGPGGPGASPSIVVAVRKRPRIPGREDDENDVVRCGENGGPSVTVYEPRTKLDLTPIIEPSSFSYDHVFGEACTNEEVYRGCCQPLLQNVREGGGAVIFAFGQTGSGKTHTMLGTGERPGLYSLAVTELLTMTEHSTMTASFYEAYGAKLYDLLNDRAEVKMLQDEYQNVHIVGITEQIVSSVDDVNALMMRGQQLRAIGTTHANDRSSRSHAVLEIKLKLADSSSESQLGRITFVDLAGSERASDTAETDAKTRREGAEINKSLLALKECIRAMSMRKRHIPFRGSKLTQILRESFVGRCKTCVIAAISPCQGHCEDTLNTLRYADRIKELKGPANPHNGVKPIPCKTCGQPIFIGDRHVCKRQLVVCPHCRQDVDKQELDTHMSECKESPMRCQYCNERMLRSESVGHSRRCARAPIRCGACGATVPRQLIDRHAQQECAEAKVKCRYCGCVQSRQLLAAHEQNCDAAKVACPHCLQFMRKRRLDGHVATCVRNLSRAMHTPRSTALNIIASTSMETSQTLASSSSSIGAQQSIPKSATAQTAASSRASSSHNRNVAAEPAGGQVDLVAADEGTGPLNFTRAHSSRRSSAQLASGVSLANQSQSNRAPGAGGRWNAGALGADEVSAACDSDCGSVVCPYSRYGCPVKVTRLNVAAHLKESMQQHLELVTTYADRVDEQNMQLRRLVIHETDTLSSRVTMERLDK
Protein: Uncharacterized protein, isoform A (Uncharacterized protein, isoform E) (Q9W2N8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDNKTTQLDFKLLVDQSLNLLDSLNTALRCDAIQFLLQTLKCKYPESCDQVVRNLFSHIAAANDNGESGGRAQQHELARTKQLQLLLTAKKEKKELGIGCEAEIKRENDEEEAGSTDLNQNFEKIPCKEEFLCLEEEEEDFLDDADTQNSSSLQFHTGNNVDALALGPGDPLELIQSGVSLLVKRKYAATFDDELIGDGDGDEANSNSSDGKMVKRKRTNNMHLTVSSVRRKEEHGQLGDGYVFHEDSQYTMRYHHSTGEFSERAFKAQFRALLRLALSQHHKPFLRQFYENFVVNGRLLGTTPSMRVLKELREQRLEEWRRQRERRQLVILMEQSETQRDEEFQQQQELVENQEEVQQEQEQQQQQLEDIQQQHLEEIQRQQQLPAISFGDSELESETESQLSSAAQEIMKFEEFIDEGVGAGRLIDGLEMEPEIDDMLAGAGSMNSASGHSSNSSSSGSGSAGNGNGISGVILENNSHHTHHLSSSSSANLVINGLTSSNSISNNNNNSNNVSLHRPQLTPQAQNQLAASMKPSDHIPISMPMENMDLKAGQAAHGTANAIMQGGSSSLASQLHQQQKPYNSSNNPLSMMGGMMQQQQQQHVAMPHHQRQMMMMPEDFPQHGASMMNSRQMPALAALSNLGDTPAMSGQLNSSLELDDNDLSADEDDDDLDHDLDELDAAKQQLIDGGSSSSTSLQAPPSQHGSGSGGSGGQTPGSKKDKPSYNCLLCPKSYRKRKSLLDHYKMHPGYCHDCGQRNGNTLEEIIHHNRTMHVKEFPFVCETCGESYSRKQQFHAHVESHNKKEIKTFPCGECGLKFPQKKLQQHFEETGHKADGAICEVCGEEFQSKNALYQHIIRVHKRDNFFECHICHNRFTLKANLERHVQLHTEIKRPYVCDLCGSSYFTYPALKEHYSNAHVDVSECKCTLCGKRFGSAKSLQRHLPSHSEERPHCCNYCDQTFKWKTHLVRHKQTMHGNEPPPPKKGKQRFPKTSEEDMGSLPDMPGPPPVKASKKAATSKAKAQAAAAAAAAASSQQQQQKGSAATPTPPPPVSTTPGCLQQDPFNAAMVSSNSSQSSTASTSQHSVSTSESQQNSIYNQSFNAEKQQPGQQQPQNTLHQQHPTPPPPQQQQQQQQQQQALPQSRVGPGELHLQRMNSFGQDGQFHFESNPAAGAYQQHQLISQYQQQQQQQQQQQQQQPQQQQQHHLAQQQQQHMRSHTPQSPHPPHPSQLQQQQPQQHFSSPHHMPPMHHQHQLMMQQQHRHNQRSPLHHHPAAQQLQQQHQQPSHSPQHQHARLQSPQPAPVQQQQQQQQQQQQQQQQFLQQQAADTWGNMNFGNPPNNQQVELKDNKFYIVESAEFLGLPMNVPPSPQQQQQQAVSKPQQQQQQQHPQPQQPDPTLAGDLMSFQHMWPAPGFSQTSQQQQPQQQQQQQAAQQQQQAQSQANSSDPHNYNNIGSILTNLIDTNPAPMEYNFDLMQQQQTPSAQQQQQQQQQQQAAQQQHHSAGAYGSGLMRSGGGVYGGAYEQHLSDQLVSEQQKQNSFQPYHPHGLQAQQQQPLHPHPHLLPPPAPHNNVYDRTGVGVGVGVGVGVGVGVGYPMLGDDTKSVLPPMMGGMMQQMPPHGQQPDLIYYPVKND
Protein: CD63 antigen (CD antigen CD63) (P41731)
Organism: Mus musculus (Mouse)
Function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P08962}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:19075008, ECO:0000269|PubMed:21041449, ECO:0000269|PubMed:23945142}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:23945142}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000250|UniProtKB:P08962}. Melanosome {ECO:0000250|UniProtKB:P08962}. Secreted, extracellular exosome {ECO:0000269|PubMed:26109643}. Cell surface {ECO:0000250|UniProtKB:P08962}. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies. {ECO:0000250|UniProtKB:P08962}.
Interaction partners:
- Tumor susceptibility gene 101 protein
- Metalloproteinase inhibitor 1
- Integrin beta-1
- CD81 antigen
- Syntenin-1
- CD9 antigen
- Syntenin-2
- Lysosome-associated membrane glycoprotein 2
- Lysosome-associated membrane glycoprotein 1
- Annexin A2
Sequence:
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDRVPDSCCINITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIRSGYEVM
Protein: MOB kinase activator 2 (Mob2 homolog) (Mps one binder kinase activator-like 2) (Ovary-specific MOB-like protein) (Q8VI63)
Organism: Mus musculus (Mouse)
Function: Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase 38-like
- Serine/threonine-protein kinase 38
Sequence:
MDWLMGKSKAKPNGKKPAAEEKKVYLEPEHTKSRITDFEFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVKKICKYLFHVLGHIYWAHFKETLALELHGHLNTLYVHFILFAREFNLLDPKETAVMDDLTEVLCSSPGNSGATGDGANSGASGAQNHVKER
Protein: Sm protein F (Q9GYZ7)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR006609}.
Interaction partners:
Sequence:
MDANVPAAFLASLVGNTVHVKSKWGPVYVGTLVSCDPYMNLQLRDAVEKAKQETELGDMLLRNNNVLYIREVPKE
Protein: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (P26281)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Interaction partners:
- GTP cyclohydrolase 1
- Dihydroneopterin aldolase
- Dihydropteroate synthase
- Poly
- Dihydrofolate synthase/folylpolyglutamate synthase
- Dihydroneopterin triphosphate 2'-epimerase
- Bifunctional chorismate mutase/prephenate dehydratase
- 6,7-dimethyl-8-ribityllumazine synthase
- Riboflavin biosynthesis protein RibD
- Dihydrofolate reductase
Sequence:
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
Protein: Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (CD antigen CD204) (P21758)
Organism: Bos taurus (Bovine)
Function: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Macrosialin
- Platelet glycoprotein 4
- T-lymphocyte activation antigen CD86
- Toll-like receptor 2
- High affinity immunoglobulin gamma Fc receptor I
- Apolipoprotein E
- Apolipoprotein B
Sequence:
MAQWDDFPDQQEDTDSCTESVKFDARSVTALLPPHPKNGPTLQERMKSYKTALITLYLIVFVVLVPIIGIVAAQLLKWETKNCTVGSVNADISPSPEGKGNGSEDEMRFREAVMERMSNMESRIQYLSDNEANLLDAKNFQNFSITTDQRFNDVLFQLNSLLSSIQEHENIIGDISKSLVGLNTTVLDLQFSIETLNGRVQENAFKQQEEMRKLEERIYNASAEIKSLDEKQVYLEQEIKGEMKLLNNITNDLRLKDWEHSQTLKNITLLQGPPGPPGEKGDRGPPGQNGIPGFPGLIGTPGLKGDRGISGLPGVRGFPGPMGKTGKPGLNGQKGQKGEKGSGSMQRQSNTVRLVGGSGPHEGRVEIFHEGQWGTVCDDRWELRGGLVVCRSLGYKGVQSVHKRAYFGKGTGPIWLNEVFCFGKESSIEECRIRQWGVRACSHDEDAGVTCTT
Protein: Glutathione exchanger 1 (P25596)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21490148}; Multi-pass membrane protein {ECO:0000269|PubMed:21490148}. Vacuole membrane {ECO:0000269|PubMed:21490148}; Multi-pass membrane protein {ECO:0000269|PubMed:21490148}.
Interaction partners:
- Vacuolar basic amino acid transporter 3
Sequence:
MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYSMTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYSEHSLLSTVQVINAVVSVGSQVVYSRLSDHFGRLRLFLVATIFYIMGTIIQSQATRLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLKWRMFYQYASYWPYIIIPWISGNIITAANPQKNWSWNIAMWAFIYPLSALPIIFLILYMKYKSSKTAEWRSLKEQARKERTGGLFENLVFLFWKLDIVGILLITVSLGCILVPLTLANETSQKWHNSKIIATLVSGGCLFFIFLYWEAKFAKSPLLPFKLLSDRGIWAPLGVTFFNFFTFFISCDYLYPVLLVSMKESSTSAARIVNLPDFVAATASPFYSLLVAKTRKLKLSVIGGCAAWMVCMGLFYKYRGGSGSHEGVIAASVIMGLSGLLCSNSVIVILQAMTTHSRMAVITGIQYTFSKLGAAIGASVSGAIWTQTMPNQLYKNLGNDTLAEIAYASPYTFISDYPWGSPERDAVVESYRYVQRIIMTVGLACTVPFFAFTMFMRDPELIDKATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKLGC
Protein: Bystin (Q80WL2)
Organism: Rattus norvegicus (Rat)
Function: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q13895}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q13895}. Note=Associated with 40S ribosomal subunits. {ECO:0000250|UniProtKB:Q13895}.
Interaction partners:
- Pre-rRNA-processing protein TSR1 homolog
- RNA-binding protein NOB1
- Protein LTV1 homolog
- NOP14 nucleolar protein
- Nucleolar complex protein 4 homolog
- U3 small nucleolar RNA-interacting protein 2
- rRNA adenine N
- Nucleolar protein 10
- Periodic tryptophan protein 2 homolog
- KRR1 small subunit processome component
Sequence:
MPKLKVTRGARNQERHAPLAEQILAGDAVRAGTREKRRRHGVEEEEEYVGPRLSRRILQQARQQQEELETEHATGDRPAKPRERATRLGPGVPQDGSDEEDEEWPTLEKAAKMTVVNHQAEVVVDPEDERAIEMFMNKNPPVRRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGILPKAFKIIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIISKCSIPVLHSSAAMLKIAEMEYSGASSIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADLATEQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVVVTME
Protein: Methyltransferase-like protein 27 (Williams-Beuren syndrome chromosomal region 27 protein) (Q8N6F8)
Organism: Homo sapiens (Human)
Interaction partners:
- Multifunctional methyltransferase subunit TRM112-like protein
Sequence:
MAQEEGGSLPEVRARVRAAHGIPDLAQKLHFYDRWAPDYDQDVATLLYRAPRLAVDCLTQALPGPPHSALILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQAPGLYQRLSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAIPELHVTKPGGLVCLTTRTNSSNLQYKEALEATLDRLEQAGMWEGLVAWPVDRLWTAGSWLPPSWRWYPASLPRMASSPALSTCTESGRRPRLRK
Protein: Plant UBX domain-containing protein 1 (PUX1) (CDC48-interacting UBX-domain protein 1) (Q9LK22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates CDC48A by inhibiting its ATPase activity and by promoting the disassembly of the active hexamer.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15498773}.
Interaction partners:
- Cell division control protein 48 homolog A
- Plant UBX domain-containing protein 3
- NPL4-like protein 2
- NPL4-like protein 1
- Plant UBX domain-containing protein 5
- Plant UBX domain-containing protein 6
- Plant UBX domain-containing protein 7
- Plant UBX domain-containing protein 4
- Cell division control protein 48 homolog D
- Plant UBX domain-containing protein 11
Sequence:
MFVDDPSLHTLKRRRLEITDSMEASSSAQAKIADMREKLGREVRVFETSSISQRPSQVSSADDESDDFYEFTPADFYRLLATKKEDKSLKTRKIREAEEAARRSKLTKAVIRVRFPDNHTLEATFHPSEKIQGLIDLVKRVVAHPDVPFYLYTTPPKKQIKDFSQDFYSAGFVPGAIVYFSNDQPKDDGGSSTPYLNEEILSLKDLEAMTKAVEPVESSSEPATVDSSAVPVEHERKSTEKKTTKPKWFKM
Protein: Protein SKG6 (Suppressor of lethality of KEX2-GAS1 double null mutant 6) (P32900)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in the polarity establishment process. Suppresses the lethality of KEX2-GAS1 double null mutant when overexpressed.
Subcellular location: Membrane {ECO:0000269|PubMed:16314687}; Single-pass membrane protein {ECO:0000269|PubMed:16314687}. Note=Localizes primarily to the growing sites, such as an incipient bud site in the cells with emerging buds, a bud tip in small- or medium-budded cells, or a cell periphery in large-budded cells.
Interaction partners:
- Kinesin-like protein KAR3
- Very long-chain fatty acid transport protein
- Protein ZDS2
Sequence:
MYHTHMHESLISVTSTVSVSDASYAYARLTRRDDSDSSSSSASSTKNSKSAECTGSKQQCQLPTDSSHSTSVTVGVAVAVPVGVIIIVLAVILCIVYRRSKKEAEEDNDPDFEGDSEFLPTMKDYSPGINHLYSSDSQQDFMEKTLQQPPSDPFVGSMHSSKYNVRSATPPAIGRSWYVDPFQLPQESNDSNSLRDFAMRVQEDGLGGYKVAAESRNASQTSLHPDNFSNCTPIRASSRFQESESFRSHGSPIHNNQLSRGSATEGANKQFTFPNEDNDSSSVSEEAEVLNESNESASNDAFEFELDNSSEKTHERNLRFGKDDDNYELQDIREAEHMNDRSSSKSQDDDYYVSLLSPNEEEDIKRMKSIYQVYLDRAKTMKKEEDKADNANDISQEENRVDNIVQNPLPSIKINNNDNIDNNEVPEAKHLVKEALPLNNTNLAEYGPEMAQSQKQYPVQDTLTVNDTEAAPSNRIASSIYSEAIQPLNYQDQYQQQEQSPVYNGHTQYPGNGYSGNPQQQGYTAQFVQNPQWYGVPTPQQQQHNHPQTLETIGELPTPAYLAQSASSHSLTSFKRPNKQQLLQLQTARLNGTALNPVDHPEMFYSPTNDAYYAPQQQGQYMKFNENGAVPSPYQLRQSVVMTNPSDLTAKPSYKPAGSFRSVSATNSRNNSLTTQNNIYLQQQQQQLYNSRVSGILEETDVVQPPSVGGILPHSGSQDDLRKQLGSSHNYTVN
Protein: Uncharacterized protein AT3g24100 (Uncharacterized protein family SERF) (Q94K36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transmembrane protein
- BAHD acyltransferase BIA1
- Metacaspase-9
- Autophagy-related protein 18b
Sequence:
MTRGSQRERDRERALARTGGKGKNKDDGLTPEQRRERDAKALQEKTAKKAAQAAAAASSGGGGGKGNNK
Protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) (Q9UPQ3)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130}. Note=Associates with the endocytic compartment.
Interaction partners:
- ADP-ribosylation factor 1
- ADP-ribosylation factor 6
- ADP-ribosylation factor 5
Sequence:
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRRNNNRNNSSGRVPTII
Protein: Serine/arginine repetitive matrix 2 (I3L1I8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNP
Protein: Chain length determinant protein (Polysaccharide antigen chain regulator) (Q8X8S6)
Organism: Escherichia coli O157:H7
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- Uncharacterized protein
- Inner membrane protein
- Inner membrane protein
- DUF2500 domain-containing protein
- Prepilin peptidase-dependent protein
- Extracellular polysaccharide production lipoprotein
- Prepilin peptidase-dependent protein
- Extracellular polysaccharide export OMA protein
- DUF2500 domain-containing protein
Sequence:
MRVENNNVSGQNHDPEQIDLIDLLVQLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSDLQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKLAQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKELRIRQIQEALQYANQAQVAKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDIENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK
Protein: Chaperone protein HscC (Hsc62) (P77319)
Organism: Escherichia coli (strain K12)
Function: Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.
Interaction partners:
- Chaperone protein DnaJ
- Uncharacterized J domain-containing protein DjlB
- Curved DNA-binding protein
- Uncharacterized J domain-containing protein DjlC
- Chaperone protein HtpG
- Protein GrpE
- Co-chaperone protein DjlA
- Chaperonin GroEL
- Pyrimidine-specific ribonucleoside hydrolase RihA
Sequence:
MDNAELAIGIDLGTTNSLIAVWKDGAAQLIPNKFGEYLTPSIISMDENNHILVGKPAVSRRTSHPDKTAALFKRAMGSNTNWRLGSDTFNAPELSSLVLRSLKEDAEEFLQRPIKDVVISVPAYFSDEQRKHTRLAAELAGLNAVRLINEPTAAAMAYGLHTQQNTRSLVFDLGGGTFDVTVLEYATPVIEVHASAGDNFLGGEDFTHMLVDEVLKRADVARTTLNESELAALYACVEAAKCSNQSPLHIRWQYQEETRECEFYENELEDLWLPLLNRLRVPIEQALRDARLKPSQIDSLVLVGGASQMPLVQRIAVRLFGKLPYQSYDPSTIVALGAAIQAACRLRSEDIEEVILTDICPYSLGVEVNRQGVSGIFSPIIERNTTVPVSRVETYSTMHPEQDSITVNVYQGENHKVKNNILVESFDVPLKKTGAYQSIDIRFSYDINGLLEVDVLLEDGSVKSRVINHSPVTLSAQQIEESRTRLSALKIYPRDMLINRTFKAKLEELWARALGDEREEIGRVITDFDAALQSNDMARVDEVRRRASDYLAIEIP
Protein: Interferon gamma receptor 1 (A0A2R8Y4U4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLKSPENSLLQFQFKYGVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
Protein: Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225) (P13164)
Organism: Homo sapiens (Human)
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Inhibits SARS-CoV-2 S protein-mediated syncytia formation. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503, ECO:0000269|PubMed:26354436}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}. Lysosome membrane {ECO:0000269|PubMed:26354436}.
Interaction partners:
- B-lymphocyte antigen CD19
- CD81 antigen
- Complement receptor type 2
- Interferon regulatory factor 9
- Interferon alpha-inducible protein 27, mitochondrial
- Ubiquitin-like protein ISG15
- Interferon alpha-inducible protein 6
- Antiviral innate immune response effector IFIT1
- Interferon-induced transmembrane protein 3
- 2'-5'-oligoadenylate synthase 1
Sequence:
MHKEEHEVAVLGPPPSTILPRSTVINIHSETSVPDHVVWSLFNTLFLNWCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGILMTIGFILLLVFGSVTVYHIMLQIIQEKRGY
Protein: Uncharacterized protein (Q584F4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Phosphatidylethanolamine-binding protein
- Ribosomal protein S24/S35 mitochondrial conserved domain-containing protein
- Uncharacterized protein
- Ribosomal protein L9 domain-containing protein
- Ribosomal protein L9 domain-containing protein
- Uncharacterized protein
- Large ribosomal subunit protein uL23m
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MFRRTFFTPMIAQPTLLMLGNKGGTPKRKKNPMQLRRKVYGLHFKEKYLKMEEWYYCPLCAEPKKPGEWCRREDCRQIKP
Protein: High-affinity glutamine permease (P48813)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High affinity transport of glutamine. Also transports Leu, Ser, Thr, Cys, Met and Asn.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14576278}; Multi-pass membrane protein {ECO:0000269|PubMed:14576278}.
Interaction partners:
- General amino acid permease AGP1
- High-affinity methionine permease
- Putative uncharacterized protein YDR509W
- SPS-sensor serine protease component SSY5
Sequence:
MTLGNRRHGRNNEGSSNMNMNRNDLDDVSHYEMKEIQPKEKQIGSIEPENEVEYFEKTVEKTIENMEYEGEHHASYLRRFIDSFRRAEGSHANSPDSSNSNGTTPISTKDSSSQLDNELNRKSSYITVDGIKQSPQEQEQKQENLKKSIKPRHTVMMSLGTGIGTGLLVGNSKVLNNAGPGGLIIGYAIMGSCVYCIIQACGELAVIYSDLIGGFNTYPLFLVDPALGFSVAWLFCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVVIFYVLIVVINVFGAKGYAEADFFFNCCKILMIVGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQRFKGVVATFVTAAFAFGMSEQLAMTASEQSNPRKAIPSAAKKMIYRILFVFLASLTLVGFLVPYTSDQLLGAAGSATKASPYVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSRILMSLAKQGNAPKCFDYIDREGRPAAAMLVSALFGVIAFCASSKKEEDVFTWLLAISGLSQLFTWITICLSHIRFRRAMKVQGRSLGEVGYKSQVGVWGSAYAVLMMVLALIAQFWVAIAPIGGGGKLSAQSFFENYLAMPIWIALYIFYKVWKKDWSLFIPADKVDLVSHRNIFDEELLKQEDEEYKERLRNGPYWKRVLDFWC