wanglab/gogpt-training-data huggingface dataset:
Protein: Claudin-7 (Q9Z1L1)
Organism: Rattus norvegicus (Rat)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O95471}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with EPCAM at the basolateral cell membrane and tight junction.
Interaction partners:
- Epithelial cell adhesion molecule
- Occludin
- Tight junction protein ZO-1
- Tight junction protein 3
- Claudin
- CD44 antigen
- Tetraspanin
- Tumor-associated calcium signal transducer 2
- Claudin
- Claudin
Sequence:
MANSGLQLLGFSMAMLGWVGLIASTAIPQWQMSSYAGDNIITAQAMYKGLWMECVTQSTGMMSCKMYDSVLALPAATQATRALMIVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMTGGIIFIVAGLAALVACSWIGHQIVTDFYNPLTPMNIKYEFGPAIFIGWAGSALVLLGGALLSCSCPGSESKAAYRAPRSYPKSNSSKEYV
Protein: 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) (B1AWD1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPEANYLLSVSWGYIKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVSTLRLFSMFLMSSTNCSFL
Protein: Neuronal growth regulator 1 (IgLON family member 4) (Q7Z3B1)
Organism: Homo sapiens (Human)
Function: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- BTB/POZ domain-containing protein KCTD15
- Transmembrane protein 18
- Glucosamine-6-phosphate deaminase 2
- IgLON family member 5
- Mitochondrial carrier homolog 2
- SH2B adapter protein 1
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Melanocortin receptor 4
- Protein transport protein Sec16B
Sequence:
MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ
Protein: Ninjurin-1 (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1] (P70617)
Organism: Rattus norvegicus (Rat)
Function: Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Acts as a mediator of both programmed and necrotic cell death (By similarity). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Plays a role in nerve regeneration by promoting maturation of Schwann cells (By similarity). Acts as a regulator of angiogenesis. Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity).
Subcellular location: [Ninjurin-1]: Cell membrane {ECO:0000250|UniProtKB:Q92982}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92982}. Synaptic cell membrane {ECO:0000250|UniProtKB:O70131}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secreted ninjurin-1]: Secreted {ECO:0000250|UniProtKB:Q92982}.
Interaction partners:
Sequence:
MDPGTEEYELNGDLRPGSPGSPDASPPRWGLRNRPINVNHYANKKSAAESMLDIALLMANASQLKAVVEQGNEFAFFVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPVMDVAPRQ
Protein: Purine nucleoside phosphoramidase (EC 3.9.1.-) (Histidine triad nucleotide binding protein HinT) (HIT protein) (P0ACE7)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine--tRNA ligase, and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Is essential for the activity of the enzyme D-alanine dehydrogenase (DadA) and is required for E.coli to grow on D-alanine as a sole carbon source. Is also required for growth at high salt concentrations.
Interaction partners:
- Uncharacterized protein YcfL
- UPF0227 protein YcfP
- Penicillin-binding protein activator LpoB
- Thiamine kinase
- Beta-hexosaminidase
Sequence:
MAEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAHKGL
Protein: UnCoupling Protein (Mitochondrial substrate carrier) (O01883)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSAVTSTSDSTAPGNSQTFKKIATKYFLSCTAALVAETVTYPLDITKTRLQIARNKFTKGGMVQVTYDIIRREGAMALWTGVAPAITRHYIYTGIRMGAYEQIRLLTFNKEVEKSFPLWKSMLCGAFSGLIAQFAASPTDLVKVQMQMEGLRRLQKQPLRYTGATDCFRSLYRTQGFFGLWIGWMPNCQRAALLNMADIATYDSVKHGLIDNFELKDNWLTHAVASACAGLAAAIVSLPSDVVKTRMMDQIRHELDAKMMHKKNTHVDLYKGVVDCYIKIIKNEGFFSLYKGFLPSYIRMAPWSLTFWVSYEEIRKWTGASSF
Protein: Ras-related protein Rab-18 (EC 3.6.5.2) (Q9NP72)
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:26063829}. Lipid droplet {ECO:0000269|PubMed:23935497, ECO:0000269|PubMed:30970241}. Apical cell membrane {ECO:0000250|UniProtKB:P35293}. Note=Localized to the ER membrane as well as to the cis-Golgi in fibroblasts. {ECO:0000269|PubMed:26063829}.
Interaction partners:
- Rab3 GTPase-activating protein catalytic subunit
- RAD50-interacting protein 1
- Rab3 GTPase-activating protein non-catalytic subunit
- Centromere/kinetochore protein zw10 homolog
- Rab GDP dissociation inhibitor alpha
- TBC1 domain family member 20
- Syntaxin-18
- Ras-related protein Rab-6A
- Perilipin-3
- Perilipin-2
Sequence:
MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREEGQGGGACGGYCSVL
Protein: polynucleotide adenylyltransferase (EC 2.7.7.19) (A1Z743)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVNKKADKDKERQQEAMLPAAGKNSSNIENSSKLSNNNNYNNNKTNKGQSTKPNSNNNSGNNKKNAGKGNQQQSQRSGKKAKPQRQQIFLQSLPRDSSNYRSNSFRNSIDINSNSSNMSSKSSSNMSSNSSNISDTLATLDSGVGKINPAELLTAALAVPCAKCSKPSMISGLTTAVTASTVPASASSSSASASSFSSSSTSSGSETASNHSDLHYPEPVVYSAKQYRKSKSYMGVSQYNSSQNGHQAGRAPNTAGGGNGNHVAYRRSHSDRRNSFDRSFAERNRDFVPIVPPPRPVLSSSNIAGVMASTTKLTIIERLGKGRLAYPIMQCGTLDGAEPLYHQQRSNRMDVYQIDDGFHSDGGTETPPPSPSSGSSIASTSDHGSLESVDTGGTQRLAVLSFEQVSKLHDVMDEKVAIHGRGNFPTLEVKLKDLVNLVRRKLEAEVNAGGAGVLVKDIRLNGGAASHVLASEDQPYNDLDLIFAIELSSPRVFDRVKVAVLNTLLDLMPEGVCKRRIYTCSLKEAYVGKMVKVNNNNDGDRWSLISLGNSPGHKNVELKFVDTMRRQFEFSVDSFQIVLDSLLLFYDCAALPISENFYPTVVGESVYGDFQEALYHLQKKLISTRQPEEIRGGGLLKYCNLLVRNYKAVDSQLIKTLERYMCSRFFIDFPDINTQTTKLEAYLRNHFWGVDEEPLQYQYLMHLREVVEMSTVCLMGHERRQSLHLIQSLAAQVLFNKQEKQQQQQAQEKYQQQQQQQQHQQNQQQQQQQRQHQFLDPAQQQQQQQQTQTQQQQAQQATTLTLVPQAPPTGQAQTIYVQQAAPAAVCCTSSADQTATAAPQTIQIQAGPPGLIYANGVYYAPVIPSTICTCNSTWLST
Protein: 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 1/3 (EC 1.1.1.395) (3alpha-hydroxysteroid dehydrogenase 1/3) (3alpha-HSDH 1/3) (Bile acid-inducible protein BaiA1) (Bile acid-inducible protein BaiA3) (P07914)
Organism: Clostridium scindens (strain JCM 10418 / VPI 12708)
Function: Involved in the multi-step bile acid 7alpha-dehydroxylation pathway that transforms primary bile acids to secondary bile acids in the human gut. Catalyzes the oxidation of C3-hydroxyl group of CoA conjugated bile acids generating a C3-oxo bile acid intermediate. Can use choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA as substrates with similar efficiency. Highly prefers NAD over NADP as cosubstrate. Also catalyzes the reverse reactions; in vitro, the preferred direction of reaction depends on the pH. Has very little activity with unconjugated (non-CoA) bile acid substrates.
Interaction partners:
Sequence:
MKLVQDKITIITGGTRGIGFAAAKLFIENGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAAVGTVAQKYGRLDVMINNAGITMNSVFSRVSEEDFKNIMDINVNGVFNGAWSAYQCMKDAKQGVIINTASVTGIYGSLSGIGYPTSKAGVIGLTHGLGREIIRKNIRVVGVAPGVVDTDMTKGLPPEILEDYLKTLPMKRMLKPEEIANVYLFLASDLASGITATTISVDGAYRP
Protein: Coagulation factor II (Thrombin) receptor-like 1, tandem duplicate 2 precursor (Putative protease-activated receptor 2b) (Zgc:165523 protein) (A5PLC2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAVSESYRILLFLACVIFASAQPGKNGRMMIVIQDDAGHIFVDQITRETLQSSLTTVFMPIIYIIVFVVGLPTNAMAIYVLLFRSKKVHPAAIYMGNLALADLMFVIWTPLKIAYHLKGNNWTYGEEMCKVSVGFFYGNMYCSILFITCLSVQRYWVCAHPLTQQRKDNRLAIIISVCVWVFIGVSTTPLYLYNQTAQLQDLNITTCHDVNIITKKSFDDRNAFLDVQEPYYYFMVMAGLVFFVPMVVIIVAYVLLLRSLGNSSVKGSAGKSRKRAVILIVTVLITFLVCFIPSNVMLVVHYSLMRNNSFNASYGFYLTALCIASLNSCLDPFIYYYVSDDFREEVKNTLQCRSSRTVERMRVSFSSMKYSKRTNTYTSSSGNTETSTC
Protein: Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350) (Q9ULW2)
Organism: Homo sapiens (Human)
Function: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Subcellular location: Cell membrane {ECO:0000305|PubMed:19188438}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein Wnt-7a
- Proto-oncogene Wnt-1
- Protein Wnt-11
- Protein Wnt-7b
- Tyrosine-protein kinase RYK
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- E3 ubiquitin-protein ligase RNF43
- E3 ubiquitin-protein ligase ZNRF3
- BMP and activin membrane-bound inhibitor homolog
Sequence:
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
Protein: GDSL esterase/lipase At1g28580 (EC 3.1.1.-) (Extracellular lipase At1g28580) (Q9FXJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Transducin/WD40 repeat-like superfamily protein
- Transcription factor bHLH147
- At1g76020
- AT3g62190/T17J13_150
Sequence:
MAYPGSPILMKLLVFIFLSTFVVTNVSSETKCREFKSIISFGDSIADTGNLLGLSDPKDLPHMAFPPYGENFFHHPTGRFSNGRLIIDFIAEFLGLPLVPPFYGSHNANFEKGVNFAVGGATALERSFLEDRGIHFPYTNVSLGVQLNSFKESLPSICGSPSDCRDMIENALILMGEIGGNDYNYAFFVDKGIEEIKELMPLVITTISSAITELIGMGGRTFLVPGEFPVGCSVLYLTSHQTSNMEEYDPLTGCLKWLNKFGENHGEQLRAELNRLQKLYPHVNIIYADYYNALFHLYQEPAKFGFMNRPLSACCGAGGPYNYTVGRKCGTDIVESCDDPSKYVAWDGVHMTEAAYRLMAEGILNGPYAIPPFDWSCRSSGVKNSGSSDT
Protein: GV1, isoform A (Q9W080)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLTPCLLLVATVASFSLHAQAIRVDWGTNTGPIAPPPPRTTPQPPRKPYRDPAPVWEDQSDDVPNPNPYVYVLPPPSRPRTWAIPAGPYAPPNYNNLPPKGNNYGQLASNSYSGGVTSVPGLAAQYVPGVGIKYTAIVSDKLQGKYNAKTKKYKAYEKAKYAYPWNYLQQLPVEEKALEWQAELEKRLDEEQSRSQALSSSTTSTTSSTSTTTSTTTTPAPLPSADSNTTAASTTTSTSTQQPTTIANYKLAHEKSAHLKKHNKQKKLLQLHMEQEKKAMKKLQQEQNSLQTS
Protein: ADP,ATP carrier protein ER-ANT1 (ADP/ATP translocase ER-ANT1) (Endoplasmic reticulum-adenine nucleotide transporter 1) (ER-ANT1) (Q8LB08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ADP:ATP antiporter that catalyzes the exchange of ADP and ATP across the endoplasmic reticulum membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18296626}; Multi-pass membrane protein {ECO:0000269|PubMed:18296626}.
Interaction partners:
- UPF0235 protein At5g63440
- Probable cysteine protease RD21C
- Probable cysteine protease RD21B
- Cysteine proteinase RD21A
- At1g09850
- Mitochondrial dicarboxylate/tricarboxylate transporter DTC
- Mitochondrial succinate-fumarate transporter 1
- Amino acid transporter ANT1
- UDP-galactose/UDP-glucose transporter 1
- Mitochondrial pyruvate carrier 1
Sequence:
MALIGKSERFSADFVMGGAAAIVAKSAAAPIERVKLLLQNQGEMIKTGHLIRPYTGLGNCFTRIYREEGVLSFWRGNQANVIRYFPTQASNFAFKGYFKNLLGCSKEKDGYLKWFAGNVASGSAAGATTSLFLYHLDYARTRLGTDAKECSVNGKRQFKGMIDVYRKTLSSDGIKGLYRGFGVSIVGITLYRGMYFGMYDTIKPIVLVGSLEGNFLASFLLGWSITTSAGVIAYPFDTLRRRMMLTSGQPVKYRNTIHALREILKSEGFYALYRGVTANMLLGVAGAGVLAGYDQLHQIAYKHWVQ
Protein: Protein TIC 62, chloroplastic (Translocon at the inner envelope membrane of chloroplasts 62) (PsTIC62) (Q8SKU2)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Involved in protein precursor import into chloroplasts. Part of the redox regulon consisting of TIC32, TIC 55 and TIC62. Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:12426385, ECO:0000269|PubMed:18180301}; Peripheral membrane protein {ECO:0000305}. Plastid, chloroplast stroma. Note=Shuttles between the membranes and the stroma, depending on the redox state of the plastidic NADP(+)/NADPH pool. {ECO:0000269|PubMed:18180301}.
Interaction partners:
Sequence:
MPMEVFSLTSTAIPSTLTRRDTAADKPSPHLNLSKYSHFMRYPLTTTLTNNRIRSSSSSSSSIRAQASGSTKSSTAEGIPEKTDSKDDNLVFVAGATGKVGSRTVRELIKLGFKVRAGVRNAQKAGALVQSVKQLKLDGASGGGEAVEKLEIVECDLEKADQIGSALGNASTVICAIGASEKEIFDITGPCRIDYRATKNLVDAATVAKVNHFILVTSLGTNKFGLPAAILNLFWGVLIWKRKAEEALLASGIPYTIVRPGGMERPTDAYKETHNVTLSTEDTLFGGQVSNLQVAELMAIMAKNPDLSYCKIVEVIAETTAPLTPAEKLLTRIPSQRPYIPSPKKVQKADTATVSNTGPSANVVAEVPSIAPQKETASKPVAKTEQPLSPYTAYDDLKPPSSPSPTKPSEKKQINISDAVPTPISSDTPSSIQEIDGISQTTSSSKGKESLSPYAAYPDLKPPSSPSPSVPTTSLSKRDTVVVSSNGPAQLSVEDTPKNEEQHLHEPKSRPLSPYAMYEDLKPPASPSPSFRKS
Protein: Recombining-binding protein suppressor of hairless (H0Y8R3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
IIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPG
Protein: Uncharacterized serine-rich protein C215.13 (O94317)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MGLRLLFSLICVFCISNIFTQAFLVHQIYGNSSFTKISLNQLEGRDSQEELQRRQEIRYYGRAAETGGTPTYYGYATPTSSSEPSIFSESATPSETNSYSSPVSSYSDPATSQLPSSTSFFSPTSSEYTPSSTESSSLLDPSSVSSAILPSSTSVEVSISSSSLSSSDPLTSSTFSSLSSSTSSSQPSVSSTSSSTFSSAAPTSTSSSYLSSSSVVSSSSSPSSSSSSTLTSSSLSTSSIPSTSSSSSSTSSSLSSSSSSSTASSSSSSSSIISSSSSSSSSPTSTSSTISSSSSSSSSPTSTSSTISSSSSSSSSFSSTLSSSSMSSSSSFSSSPTSSSSTISSSSSSPSSSSFSSTTSSSKSSSSFSSTVSSSSSTSSSTLTSSSSSSSRPASSSSHSSSLSSHKSSSSSKSSSAPVSSAFYHNSTSSRSSSHSSSHSLSSLSSKPILTASSSSLLTSSSHTYERSTVYVVTVETVSSGSSTYASQSTQTSILLVIVGDSSSTDSSGASSTHSKTSIFFSLFVVLAAAIVII
Protein: Pyruvate kinase II (EC 2.7.1.40) (PK-2) (P21599)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis.
Interaction partners:
- Enolase
- Glucose-6-phosphate isomerase
- NADP-dependent malic enzyme
- Phosphoenolpyruvate carboxykinase
- Phosphoenolpyruvate synthase
- Phosphoenolpyruvate carboxylase
- Glucose-6-phosphate 1-dehydrogenase
- NAD-dependent malic enzyme
- Transketolase 1
- Phosphoglycerate kinase
Sequence:
MSRRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSQDAMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFDSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTVE
Protein: Uncharacterized protein (Q381F0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cleavage and polyadenylation specificity factor 30 kDa subunit
- Cleavage and polyadenylation specificity factor subunit, putative
- Cleavage and polyadenylation specificity factor-like protein, putative
- C3H1-type domain-containing protein
- Uncharacterized protein
- Cleavage and polyadenylation specificity factor subunit 2
- Nucleic acid binding protein, putative
- SET domain-containing protein
- D-alanine--D-alanine ligase
- Poly
Sequence:
MKNYTPVEIAASFFSAYGDPRSTSIDFSLDGKYFLSTHTDDAMRLVDVTEIKHKETIALNTVGLWRARFTQSSGVVCLASHRPCDGHLYLLNLNTAQLFASMSFVSDTVPVVPAIPNRPAYTAIAQSPCNDTIAAVFSAQGRLLLFHPLISGAVAASAENTFIGGGGAISFSPEGTQLLVSDDSCVRVYDYRKLFSGPLLTLQHNKMLPHCDSCGERRCIGMDIGSGGEELLLTYECGGVLLYDLRQNAVRGANFGIKGTIDGINSSCSVGARYVHPYLGHSPVVQLDSTSGKDTRLLVYHGSRAKSRWGSLRYEILCVADGDPIAMSVNPQYSMVATAAGGVTWWSFPPR
Protein: Heat shock protein 105 kDa (Heat shock 110 kDa protein) (Q60446)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q92598}.
Interaction partners:
Sequence:
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFSDPFIQKEKESLSYDLVPMKNGGVGIKVMYMDEEHLFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKPQGSGVCGHGPSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHSLMEQTHLKTEDVSAIEIVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEDDGSSVEADMECPNQKPAESSDVDKNSQQDNSEAGTQPQVQTDGQQTSQSPPSPELPSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICQQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGNPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRSKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVNQPKPKIESPKLERTPNGPNLDKKEDLEGKDNFGAEAPHQNGECHPNEKGSVNMDLD
Protein: Probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 (Protein EMBRYO DEFFECTIVE 40) (Protein GORDO) (Protein TONNEAU 2) (Q9FEE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable regulatory subunit of type 2A protein phosphatase involved in the control of the dynamic organization of the cortical cytoskeleton. Plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. Required for the reorganization of cortical arrays in response to light.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22395485}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22395485}. Note=Predominantly cytoplasmic, but at the late G2 phase localizes at the cortical region corresponding to the preprophase band.
Interaction partners:
- Protein TONNEAU 1b
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Protein TONNEAU 1a
- AT3g12300/F28J15_117
- Kinesin-like protein KIN-12C
- Transcription repressor OFP5
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Transcription repressor OFP2
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
Sequence:
MYSGSSDGESHDTSTQRKIPPASSMLWVRNLRRYIGSGAGLGSEALMELETKRILLEIFKEKQQKSQEAGTIPSFYKKKPEEGSISQRVQKLAKYRFLKKQSDLLLNADDLAAMWVCLRENCVIDDATGAEKMNYEDFCHIASVCTEQIGPKCRRFFSPSNFMKFEKDEAGRIAILPFYLYVMRTVSLTQARIDMSELDEDSDGFLHSDEMESYIGGLIPNLAQLRDMPPAFNQMYCRIASQKFFFFCDPHRRGRACIKKILLSNCLQELMELHQESEEEVTDTEQAENWFSLTSAQRICDMFLALDKDMSGSLCKQELKEYADGTLTEIFIERVFDEHVRRGKIVAGNSREMDFDSFLDFVLALENKDTPEGLTYLFRCLDLQGRGFLTTADIHSLFRDVHQKWIEGGNYELCIEDVRDEIWDMVKPSDPLKITLGDLLGCKQGGTVASMLIDVRGFWAHDNRENLLQEEEEPPEEESQ