wanglab/gogpt-training-data huggingface dataset:
Protein: D-Importin 7/RanBP7 (FI03666p) (Moleskin) (Q9VSD6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Importin subunit beta
- Importin subunit alpha
- Mitogen-activated protein kinase ERK-A
- Importin subunit alpha
- GTP-binding nuclear protein Ran
- Importin subunit alpha
- Transportin-3
- Transportin-1
- FI07923p
- Nuclear pore complex protein Nup153
Sequence:
MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNLINSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWPQVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQSEQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVPDSSHLDDDERTEFPYWKTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRVLTDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDYATPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQHLATTFSQVLESEEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHNITDFYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNPNRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQIDSVIHMFVELALSRLTREVQSSELRTMCLQVVIAALYYNPQLLLSILDKMSQQNNDSISAHFIKQWLHDTDCFLGIHDRKLCVLGLCTLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQEEEEDEEEEDGDDCEEALSSDEDDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQGGFAFPQTAVPTSFKFGS
Protein: Replication factor C, subunit 1, putative (Q385K3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Replication factor C, subunit 5, putative
- DNA polymerase eta
- Replication factor C, subunit 2, putative
- Replication factor C, subunit 4, putative
- Replication factor C, subunit 3, putative
- Proliferating cell nuclear antigen
- Flap endonuclease 1
- DNA polymerase epsilon catalytic subunit
- DNA polymerase alpha subunit B
- Protein artemis
Sequence:
MMTSSPSSIEVPHSWAEKYKPKTIAQMCYPVTANKLKQWMEEFEANSSKMRGALLSGPPGVGKTTSVYVVASELGRVVVEYNASDFRSRKSLRENVSTVVNNRTFSNTSSSYANIVLLMDEVDGCDIGGVGEVIQMIKNTNVPIICTCNDRWHPKLRSLLNHVEDIRAGRPPCNIVANYLCDKVLAREGISLSKQLLQDIIQRSGSDIRSMLNNLQMWCINQTSLQQKKLAECALQSAKDGDVGLFEAAEVFLLQGSSRGRPRSIEELQSTFYNSDLVDMFVQENYLHFKPEDRDWMDAVAEAASSISLSDLAQRIMFFENNWSVSRSHVLLSSIIPCALTRGHYETFVTGQQAIFDRQRPVKFPSWLGQNSAAGKNKRLLRCLTFQAMGHSKGISGTQEDVLLDYIPRAWESRLTDPLAQRGKDAIPEVIAFMDQYHIMRDDWEFIQSVAHFKKMQSASPNPAAGDIPGGIKAAFTREFNKTHRLESFAKGALQRVATDGIGFGEGEEDNEEEGSVAGASRPTAKKASAKTAAKPKKAAKKEGNENAKPKKAAAKTAKPAGRRGRKATLVDSDSEPEFESYSSDDY
Protein: Uncharacterized protein (Q381T8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLKLPTIAHTVQADCQPAAGMGRGPGLPHLPSWDQPAVIKLDPINPPSPYRPSLPRHRYPTVLESLPRVSGVRAEASARPGLHSFGTKGTVKPDESLFEYEYACVLNICKREKESRDDIIFEEQRISVRLWVDYLAEAGIHLSNDICLREEEARNLIEREEERRYMCFFIEMTSTADNMQRRFEANLRKQIEEIMPDYKRMRETAVEEEKQDLKTLLTWFKDNRPFNMILPSFFFEEDKNRRRLPPSLCKRKVKPVTNTRSKRYDSIHTSNKDNSTDRFLEEAFLEEGRRAWRVEKQRGFAGHRMTLKINDINNEEVATRDDIIMEELLQRVAFDTAAIASMCDVKMKVAKRRTQEAKMEKELLIEEEKRKAILDKLKEESILKGENELNMCLLDEPTEKEMQLVNAIQHKQGESVSPPVEDRNCEKLSEEVSPCGKYTNLNSQEEHEAIQTLIEFENNLRHGGGGAPDCRATAGDSDSKCGGVSPAGRLEGRSQQRLSLPLERASSAALTLKTSCESEAFKEFQASIRSRDSSASKRTDIAISVEDERVILDVLKVFEDSARMRENMSPEDRHVAECVRNVVCAPNGSKGRDTDVKSSGDATATQTELVRSLEEEHEILNLLMEQELKLQVANDAEFRRRLSGGGVKDCMFQRGTPVGVCCGETPSTSPDSAMFPMLNIVLSIAAERDPYVMLGNSALSALGEAECTIAASAGRKVGEIARVFAQAQYTPLCPVYLLRGLWCTESSTGSSLDSEDVEELTVQLLQWEARERNEIIHTQIDTIWELYNKAAKEASCLTNTGYGDVYYVGVRIHNESLKRREME
Protein: LOB domain-containing protein 36 (ASYMMETRIC LEAVES 2-like protein 1) (AS2-like protein 1) (Q9FKZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Controls the proximal-distal patterning in petals and the adaxial-abaxial determination of leaves. Involved in the repression of the homeobox gene BP.
Interaction partners:
- Small ribosomal subunit protein bS20c
- LOB domain-containing protein 42
- Transferase-like protein
- LOB domain-containing protein 39
- At5g05500
Sequence:
MASSSSPCAACKFLRRKCTQECVFAPYFPPDQPQKFAFVHKVFGASNVAKLLNELASNQREDAVNSLFYEAEARLRDPVYGCVGLISILQHRLKQVNHDLENAKKELATYVGPQAMLPILQPHFMSLPPQPQRPSSSSASVLTQHHHNLLPMMAIPTGQLYHQQQQQIFEAQQLAAVAREQQNEMFRAYGGGGGSSSPHHQNQAQAEILRFNNGFDSVPAGSVTVTGFNQLSSGGTAVTGMSLGGNFVDSPSTNNNYHTDQQLHHHHQPQQHHEAQLFIPSQSSQPLPLQTQETQTQTQPNSESEEGRRNVIG
Protein: RuBisCO accumulation factor 1 (Q31Q05)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: A major RuBisCO chaperone. Acts after GroEL-GroES chaperonin to fold and/or assemble the large subunit of RuBisCO (ccbL, rbcL). Cooperates with RbcX in RbcL folding, plays the major role in assembly of dimers into RbcL(8)-Raf1(8) intermediate complexes. RbcS replaces Raf1, leading to holoenzyme formation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00856}.
Interaction partners:
- Ribulose bisphosphate carboxylase large chain
- RuBisCO chaperone RbcX
- Carboxysome assembly protein CcmN
- DUF1830 domain-containing protein
- TIGR02652 family protein
- Mo-dependent nitrogenase C-terminal domain-containing protein
- Molecular chaperone DnaJ
- Cofactor assembly of complex C subunit B
- DUF2973 domain-containing protein
- Uncharacterized protein
Sequence:
MREFTPTTLSEEERQELLGQLRRKEGRWLAWARACQTLLKNGLNPQTLFEATGFEPIQQNQITVAMQVYDSILRQDPPAHVRETYQEWGSDLLYELRELDQEQRSLCAQLALERKLDADQIREVAKATKDFCRLPKQPENFDRHPGDAVAHQCWRLAQERTDLTERSRLIARGLQFAQSAGARALIEALLLDLSGVPSRKPPMLPIYRLETEEDLPRLLPFAGTLPLSSSQIEAIAAVEAEGPFGLVSSPQGQQWLALPGWQAILTAEDPIACLEQIDRLPNAPEGPTEAVVLVVDRADRDWDADHFFLVEQAEGARIQWSPSAIAAPILGRLVLILRPKRVLDEAAIATPWQFEE
Protein: PAXIP1-associated glutamate-rich protein 1A (PAXIP1-associated protein 1) (PTIP-associated protein 1) (Q99L02)
Organism: Mus musculus (Mouse)
Function: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development.
Subcellular location: Nucleus {ECO:0000269|PubMed:26744420}.
Interaction partners:
- PAX-interacting protein 1
- Lysine-specific demethylase 6A
- Nuclear receptor coactivator 6
- Histone-lysine N-methyltransferase 2D
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5
- Histone-lysine N-methyltransferase 2C
- WD repeat-containing protein 5
- Protein dpy-30 homolog
Sequence:
MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY
Protein: DNA 3'-5' helicase XPB (EC 5.6.2.4) (O53873)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: ATP-dependent 3'-5' DNA helicase, unwinds 3'-overhangs, 3'- flaps, and splayed-arm DNA substrates but not 5'-overhangs, 5'-flap substrates, 3-way junctions or Holliday junctions. Not highly efficient in vitro. Requires ATP hydrolysis for helicase activity; the ATPase activity is DNA-dependent and requires a minimum of 4 single-stranded nucleotides (nt) with 6-10 nt providing all necessary interactions for full processive unwinding. The ATPase prefers ATP over CTP or GTP, is almost inactive with TTP. DNA helicase activity requires ATP or dATP and only acts when the 3'-overhang is >20 nt. Capable of unwinding a DNA:RNA hybrid if the 3'-overhang is DNA. Also catalyzes ATP-independent annealing of complementary DNA strands; annealing requires Mg(2+).
Interaction partners:
- ATP-dependent helicase DinG
- Conserved protein
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- Probable helicase HelZ
- DNA polymerase I
- 5'-3' exonuclease
- ERCC4 domain-containing protein
- DNA-directed RNA polymerase subunit beta'
Sequence:
MTDGPLIVQSDKTVLLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAEQVVDALVSYSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRAVLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQLLLKIGWPAEDLAGYVDGEAHPISLHQEGWQLRDYQRLAADSFWAGGSGVVVLPCGAGKTLVGAAAMAKAGATTLILVTNIVAARQWKRELVARTSLTENEIGEFSGERKEIRPVTISTYQMITRRTKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADLQSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECVEVRVTMTDSERMMYATAEPEERYRICSTVHTKIAVVKSILAKHPDEQTLVIGAYLDQLDELGAELGAPVIQGSTRTSEREALFDAFRRGEVATLVVSKVANFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRILRPKADGGGAIFYSVVARDSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI
Protein: CMP-sialic acid transporter (CMP-SA-Tr) (CMP-Sia-Tr) (CST) (Solute carrier family 35 member A1) (P78382)
Organism: Homo sapiens (Human)
Function: Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity). Also able to exchange CMP-sialic acid for AMP and UMP. Also mediates the transport of CDP-ribitol (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q61420}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q61420}. Golgi apparatus {ECO:0000269|PubMed:23873973}.
Interaction partners:
- Adhesion G protein-coupled receptor L1
- Nucleotide sugar transporter SLC35D2
- Nucleotide sugar transporter SLC35D1
- Solute carrier family 35 member D3
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- GDP-fucose transporter 1
- Phosphomannomutase 2
- N-acetylneuraminate-9-phosphate synthase
- N-acylneuraminate cytidylyltransferase
Sequence:
MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV
Protein: Arabinolytic transcriptional activator araR (Q5BGE2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Transcriptional activator of the arabinanolytic system. Involved in the regulation of extracellular arabinanolytic genes and in the regulation of the intracellular activities of L-arabinose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of L-arabinose.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
Sequence:
MASSHQGNGTVPNSQTDAPPDSSTKRRWRRNRIACDSCHARRVRCDRQFPCSRCLRSEITCEFTRERRKRGRIARSKLAEMAKNKMETSETPAPAKTMNGIPAPAGTEIPGHVSPASTFHHRSPPANAPTVSAPSVDGRRSQTDPQLPVRRPEIGGNVTEEWLAGTHVSPGSYEFLNGPAFGEGLGPFPHMFDVWNGVDLAAYSAGTSQGSKATNAPSTSTAPLKYPVLQPLMPFVEATLPRKLVFDLLDLYFTSAFSTHMHPVSFLSKDAPRPSSPALLSSMLWVAALDDRAFSLPISPPQRKRICQFLCALTIRLLRPLIHVSFKDQGGAAAAVAAAAAAATNNPAFAGVGQDLPPTTVHHPFEGGGDDRGLVGPAGSLDDVITYIHVASIISSSEQKAASMRWWHAAFTLARELKLNQEIEVMPNGDSQVEGSSPPFGYSLPGWDGADPGPVFNYSNPTRSSLNCVCDRQDQNTITEEHREERRRTWWLLYIMDRHLALCYNRPLALLDAESEDLLLPLDEASWQSGIIHSNSPKSDGPQCLLSADKNKRRLFPNFICHDHSVFGFFLPLMTITGELIDLNQARNHPMLGMRLNGKDAWNVHVSEVLRQLEIYKASLTTFAATTSDPEAPLSAYAHAQSEHLPAEPSLSQAYAWHTQTVISYASYLVHVLHILLVGKWDPVSLIEDKDFWTSSPAFASTISHALDAADSVDQILRYDPDISFMPYFFGIQLLQGSFLLLLIVERLQKEAGEGILNACEVMIRATESCVVTLNTEYQRNFRQVMRSAVAQARGRPVNHSEIRHRRKAVLALYRWTRKGTGLAL
Protein: Proteasome subunit alpha type (B5X619)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVVVTQKKVPDKLLDASTVTHLFRITENIGCVMSGMTADSKSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMIVIGVDEECGPQVYKCDPAGYYCGFKATAAGVKQTEATSFLEKKVKKKLDWTFKETVETAITCLSTVLSIDFKPSELEIGVITTEDPKFRILTESEVDIHLVSLAERD
Protein: Doublesex- and mab-3-related transcription factor dmd-10 (G5EEJ1)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Plays a role in neuronal signaling in polymodal sensory neuron ASH, downstream of sensory receptor activation. Required for maintenance of AVG synapses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- DM domain-containing protein.
- DM domain-containing protein
Sequence:
MVADVLRQSVLVPISMYPQYPVPRRYTTSVFKEYQKKKKIYYCQRCLNHDVPRPRKNHKCECPYADCTCEKCGLVEKRRILNIRLQNYNQFNIENENDSKLIIVEDDDKKKQGERVPNCQKCGQHGRKSRLKGHKRSCPFRECPCAKCAVVSERQKLMADQIKIRRRQRKDTLLTFAKNSITSTMFPSNQISLNALNSLLYGSINTSPQPLLSSPTSSDASSCSPSMPFTPSIPMFMPTSADCSPTTQTPTSSIPSSIASTSPLMTSLPLRLSGFPLLNIRDPSAEASLLNLGCNADAAALLKTILDQYRMLEEASMSMSSSPSKDDESGDEDSDGLNSNSIIDVITV
Protein: Tropomyosin 3 (Tropomyosin alpha-3 chain isoform 1) (Zgc:77592) (Q6P0W3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEAVKKKMMMLKLDKENALDQAEQAETDRKAAEERSKQHEDELIQMQKKLKGTEDELDKYSEALKDAQEKLEISEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIVEGELERTEERAELAESKCAELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Protein: Rifin (O96117)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFTLPLNILVNGQGHYSSTKHPISSTKSSKYHRSLCECEIYTSIYDNDPEMKKVMQDFDQQTSQRLREYDERLIKNRQKCKDQCDKDIQKIILKDKIEKELTKQLEALEVDITTEDIPACVCKKSVEDKVGKNCLKCGGILGGGIPGLGVLGAYAVNSMVQVAMDAAKKAAIAEGAEAGIAEGIKVAIQGVPKKFLLYTLNGKELQAVINANNFQNPSFFYGEIMAEYVSWKKSDMVNSYGLFSFIEESCENNPDKIMKFILANSNDIAKDAGKAATKMTTQTTEALTLKKTAEATSTSAIFSNPIVISFIVLVIIVLILLIIYLILRYRRKRKMKKKLQYLKLLKE
Protein: 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase (EC 1.13.11.16) (3-carboxyethylcatechol 2,3-dioxygenase) (P0ABR9)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
Interaction partners:
- 3-
- 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
- Acetaldehyde dehydrogenase
- 2-keto-4-pentenoate hydratase
- 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenasepropanoate dehydrogenase)
- 4-hydroxy-2-oxovalerate aldolase
- DNA-binding transcriptional activator MhpR
- HTH-type transcriptional repressor BdcR
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
- 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
Sequence:
MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
Protein: Temporin-CDYe (B3VZU6)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P79874}.
Interaction partners:
Sequence:
MFTLKKSMLLLLFLGTISLTLCEEERDANEEEENGGEVKVEEKRFIGPIISALASLFGG
Protein: Integral membrane protein 2 (Q8T0C2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU367061}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU367061}.
Interaction partners:
Sequence:
MVFNRPQHHCIKSFLLFLIAVVVMLLGVLGGWTLYRVYAPSHSSMRYHALCEIPYPEDSMEMTRVYPRTVEPFALNWRSLLPELAQPMPNSGSLDESHFREDIELDGDSDDEGYARVDVPDFKDGRRGRFMHDFKENQSAIIDTTTGRCFIMPLDRDTTLPPTSFVDLIKKMSTGYYNIDTERVRRQMRVVMPRITDVSLISERIANECFDMKVYMMEKFVSGVSKRSADPLPESAKYAEFMGKGVIEYDLANIAEVEAYEANEARQQA
Protein: Tetraspanin-17 (Tspan-17) (F-box only protein 23) (Tetraspan protein SB134) (Transmembrane 4 superfamily member 17) (Q9D7W4)
Organism: Mus musculus (Mouse)
Function: Regulates ADAM10 maturation.
Subcellular location: Cell membrane {ECO:0000305|PubMed:26668317}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 10
- Tetraspanin-31
Sequence:
MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDLDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQEGSIYTKGCVGQFEKWLQDNLIVVAGVLVGIALLQIFGLCLAQNLVSDIKAVKANW
Protein: Uncharacterized protein (Q54DE4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- SCF ubiquitin ligase complex protein SKP1a
- SCF ubiquitin ligase complex protein SKP1b
- Cullin-5
Sequence:
MSYDYNCWVCFELFTEPVTLYCSHSFCKECIEKSYHIEQLCPFCRKEIQMPLPPIDKELNKKILKLKGFDVDENNNNTNNNNNNNNNTSNNNNNRDVVMEESQPIKKITYGILNLPSTIYAQIFSEFPVKEILKFSLVCKEFNKAINHKFLWKIKLFQFIEFFNTEKYEYDYKKCFKICYQNEKNENKGAAGTFKMVPFRGHSQPITSIQHIGNVMCTGSVDSTVKVWDLSSKKGTNTQTFTGHSGSVTCIKQRQYSVISGSDDCSVRVWDFEKGVESNCLKTESPILSIDYNVNIGGDGQIIATNKDTIQIWDHRDKQSGDGMVGISGEVFSSKFHSNGHLFVHTSDYLDSWDLRRFDRPILRLPSPQWYQPTKDFVYVFSNNRSILKYNILNGKLMGSKSLSNHFSIAGGHQLFSATNDNVAYNIGDFNVHLLDSNLNPLLVLSNHTNQINSITIDNKKILTGSKDNTIKVWDKQSGNRLYSLLGGSNIVNPSDPIPLTPGCSLVNYDRSRIIGVFNNLVRLYNFNLD
Protein: Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (RL 14.5) (S-Lac lectin 1) (P11762)
Organism: Rattus norvegicus (Rat)
Function: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P09382}. Cytoplasm {ECO:0000250|UniProtKB:P09382}. Secreted {ECO:0000250|UniProtKB:P09382}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P09382}.
Interaction partners:
- Epithelial membrane protein 3
- Protein S100-A4
- Receptor-type tyrosine-protein phosphatase C
- Galectin-2
- Vimentin
- Annexin A1
- Annexin A2
- Lumican
Sequence:
MACGLVASNLNLKPGECLKVRGELAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE
Protein: U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (A0A0G2JTI7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8
- U4/U6 small nuclear ribonucleoprotein Prp4
- U4/U6 small nuclear ribonucleoprotein Prp31
- Pre-mRNA-processing factor 6
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Peptidyl-prolyl cis-trans isomerase
- U4/U6.U5 tri-snRNP-associated protein 1
- U6 snRNA-associated Sm-like protein LSm8
- 116 kDa U5 small nuclear ribonucleoprotein component
- Splicing factor 3b, subunit 2
Sequence:
MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEVRHSQRPELWRDEVQTVPYREHGA
Protein: EWS RNA-binding protein 1 (A0A8J8Y9N6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQSTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQAYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPAETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSSQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSGPGENRSLSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGGKFLSLPIDPDEDSDNSAVYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPLNSMRGGMPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGPGKMDKGEHRQERRDRPY
Protein: Deoxyguanosine kinase, mitochondrial (EC 2.7.1.113) (Deoxyadenosine kinase, mitochondrial) (EC 2.7.1.76) (Q9QX60)
Organism: Mus musculus (Mouse)
Function: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:10455141}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10455141}.
Interaction partners:
- 5'
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Cytosolic purine 5'-nucleotidase
- 5'
- Cytosolic 5'-nucleotidase 3A
- 7-methylguanosine phosphate-specific 5'-nucleotidase
- Guanylate kinase
- Inosine triphosphate pyrophosphatase
- 5'-nucleotidase
Sequence:
MAAGRFLLRRLRASFRSPLRNALVDAPHARAMHDGGGPRRLCIEGNIAVGKSTFVKLLMKTHPEWQVATEPIAEWQNIQAAGAQKDGTSKRLGNLLEMMYQEPARWSYTFQTLSFMSRLKVQLEPIPGRLLQAEKSVRVFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLQEFANRLLLHGFIYLQASPQVCMERLYQRDREEEKGIELAYLQQLHSQHEDWFINKTTKLHFEALQHVPVLVLDVTEDFSENAARQEELMGQVNTFMRNL
Protein: Lipoprotein (O53716)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Orotate phosphoribosyltransferase
- Possible RNA methyltransferase
- Possible conserved secreted protein
Sequence:
MRILVAWATCGAVVLSGLTGCSGSSHSGRTYGAQSARTGESLAVLGWNMSVSNLRWSGDYVLIDVDASPTDPHAPHAKPEDIRFGLYGALAHPMESAALGSCGDAMAHVRDVVSPLSAPAGRLTGTVCLGPLKERSAVRGVYTYSPRDRIPGTAAAYPAAFPVGMLPTNQNDAGLVVKTTSVSAWRADGMQLGKPQLGDPVAFTGNGYMLLGLEVDAVPDRYRDDSAARGGPMMLLAAPTLPGRGLSPACATYGSSVLILPDALLDAVHISASLCTQGEINEALLYATVATVGTHAALWTSR