wanglab/gogpt-training-data huggingface dataset:
Protein: NADP-dependent malic enzyme 4, chloroplastic (AtNADP-ME4) (NADP-malic enzyme 4) (EC 1.1.1.40) (Q9CA83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The chloroplastic ME isoform decarboxylates malate shuttled from neighboring mesophyll cells. The CO(2) released is then refixed by ribulose-bisphosphate carboxylase. This pathway eliminates the photorespiratory loss of CO(2) that occurs in most plants (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16113210, ECO:0000269|PubMed:21841088}.
Interaction partners:
- Malate synthase
- Fumarate hydratase 2
- Fumarate hydratase 1, mitochondrial
- Malate dehydrogenase, chloroplastic
- Pyruvate, phosphate dikinase 1, chloroplastic
- Alanine aminotransferase 1, mitochondrial
- D-lactate dehydrogenase [cytochrome], mitochondrial
- L-lactate dehydrogenase
- Glutamate--glyoxylate aminotransferase 2
- Acetolactate synthase, chloroplastic
Sequence:
MISLTPSLFLNKTVVPGCSTRLSLRQPRTIITPPASLRVFSSLGSNQDPTGSVLIETTATSSSSLETSAADIVPKSTVSGGVQDVYGEDAATEDMPITPWSLSVASGYTLLRDPHHNKGLAFSHRERDAHYLRGLLPPTVISQDLQVKKIMHTLRQYQVPLQKYMAMMDLQETNERLFYKLLIDHVEELLPVIYTPTVGEACQKYGSIFLRPQGLFISLKEKGKIHEVLRNWPEKNIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSACLPVTIDVGTNNEKLLNDEFYIGLRQRRATGEEYSELMHEFMTAVKQNYGEKVVIQFEDFANHNAFDLLAKYGTTHLVFNDDIQGTASVVLAGLIAALRFVGGSLSDHRFLFLGAGEAGTGIAELIALEISKKSHIPLEEARKNIWLVDSKGLIVSSRKESIQHFKKPWAHDHEPIRELVDAVKAIKPTVLIGTSGVGQTFTQDVVETMAKLNEKPIILSLSNPTSQSECTAEEAYTWSQGRAIFASGSPFAPVEYEGKTFVPGQANNAYIFPGFGLGLIMSGTIRVHDDMLLAASEALAEELMEEHYEKGMIYPPFRNIRKISARIAAKVAAKAYELGLATRLPQPKELEQCAESSMYSPSYRSYR
Protein: Exocyst complex component SEC5 (P89102)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Interaction partners:
- Exocyst complex component SEC3
- Exocyst complex component SEC8
- Exocyst complex component EXO70
- Exocyst complex component EXO84
- Exocyst complex component SEC10
- Exocyst complex component SEC6
- Exocyst complex component SEC15
- Ras-related protein SEC4
- Protein transport protein SEC9
- Protein transport protein SEC1
Sequence:
MDRFQIGDEQLLRFYQLKTINPTHSWAQDSSKLNNEEATSNELGVETSFDILKDFKYGNQISIDKESRAYLNDESLSYIRDPLNGQEMSKELQHLPNDSMRLNYLVNSKQFNVKAFLRDMHKQDSFNDLNNSLDRLDSDIQDQSIHLKQLVGKNFTKYVKIKNKLDQIYKEFDEKTNEKNQCDSPKENQINVESLNKKVDEVIRTTTFKLKPLMDNYQKILNYQATKKFIELNKFYFNLPKSLKRCLTNNDFNEFIIEYSKGLTLRRRFNQSSDASQSLVIKRIWTQIENLLVTYKDLIWNSLINSNFNIDQPQETILSLFSKLLNLENFINNNQRESESGNKNTTSSSNENPILRWMSIKMNGFQNELNELSGHMISKIIHSQRLILQNNTNQDKSQGCVELSYYLKINQLFQIISDTGKDSEGLKSTVEPNKVNTISGTSYLNLNCQPSSQGLTDSPTIIEMWLLILKYINDLWKICDQFIEFWEHIEKFLDGTYQNSIINEKRKENILIGDSNIIESYQKSLILKEEQINEVRLKGEEFITSVSQNLISFFTSSQSSLPSSLKDSTGDITRSNKDSGSPLDYGFIPPNCNGLSCLRYLPKIVEPILKFSTELAQLNITTNGITICRNTLSTIINRCVGAISSTKLRDISNFYQLENWQVYETVTFSSKSQDSSKNLTFEYGVTQFPEIVTSFQEVSIKTTRDLLFAYEKLPIINGISVVSYPSKQLLTGIEIQQIISMEAVLEAILKNAAKDKDNPRNSHTILTLTNLQYFRECAFPNILQYFDDAFEWNLASKNLELFSLLSKMESSIFGNYLSDLKINLRDTLEEKFHEINWPMYTSNSFRVGDYIIEALMILIVVHSECFRIGPQLIHKILIETQIFIARYLFEAFKPYVGNLSNDGSLQIIVDLEFFQKVMGPLLEKDTEATLRACLQNCFQNDTNRLQKCINEINPIVSANLKRTAIQFAAFS
Protein: Alcohol dehydrogenase 1 (EC 1.1.1.1) (Q43264)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- pyruvate decarboxylase
- hydroperoxide dehydratase
- pyruvate decarboxylase
- Aldose reductase
- Aldo-keto reductase family 4 member C9
- Aldo-keto reductase family 4 member C9
- Alcohol dehydrogenase-like 3
- pyruvate decarboxylase
- pyruvate decarboxylase
- Alcohol dehydrogenase-like 6
Sequence:
MATAGKVIKCKAAVAWEAGKPLSIEEVEVAPPQAMEVRVKILFTSLCHTDVYFWEAKGQTPVFPRIFGHEAGGIIESVGEGVTDVAPGDHVLPVFTGECKECAHCKSAESNMCDLLRINTDRGVMIADGKSRFSINGKPIYHFVGTSTFSEYTVMHVGCVAKINPQAPLDKVCVLSCGISTGLGASINVAKPPKGSTVAVFGLGAVGLAAAEGARIAGASRIIGVDLNPSRFEEARKFGCTEFVNPKDHNKPVQEVLAEMTNGGVDRSVECTGNINAMIQAFECVHDGWGVAVLVGVPHKDAEFKTHPMNFLNERTLKGTFFGNYKPRTDLPNVVELYMKKELEVEKFITHSVPFAEINKAFDLMAKGEGIRCIIRMEN
Protein: Protein CNGC15a (Cyclic nucleotide-gated ion channel protein 15 a) (G7IBJ4)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Cyclic nucleotide-gated channel involved in the establishment of both rhizobial and mycorrhizal associations. Required for full activation of nuclear-localized Ca(2+) oscillations by Nod and Myc factors. Simultaneous activation of the K(+)-permeable channel DMI1 and the Ca(2+) channel CNGC15 can give rise to sustained Ca(2+) oscillations. May function during fertilization in both female and male gametophytic Ca(2+) signaling.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:27230377}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASVISRAVRFHDDLEKEKLQEGEESHMEMRAYEMSSEYKHGKDAINKPSSNGRGLSRVFSEDYDAGEILVFDPRGPRINLWNKIFLAACLISLFVDPLFFYLPVAKKEKCIDMSIGLEVSLTIIRTFVDAFYIIHIYIRFQTAYIAPSSRVSGRGELIIDSSKIASNYMKKELWSDLVAALPLPQVLIWAVIPNIKGSEMIASRHVVRLVSIFQYLLRLYLIYPLSSKITKASGVMMEKAWAGAAYYLTLYMLASHVLGSTWYLLSIERQDECWKKACTLQYPHCQYHYLDCQSLSDPNRNAWLKSSNLSGLCDQNSHFFQFGIFDDAVTLEITSSNFLTKYYYCLWWGLRNLSSSGENLLTSTHVAEINFAVIVAILGLVLFALLIGNMQTYLQSTTIRLEEWRIRRTDTERWMHHRQLPHYLKENVRRHDQFRWVATRGVDEEAILRDLPVDLRRDIKRHLCLNLVRQVPLFDQMDDRMLDAICERLKPTLCTPGTCIVREGDPVDEMLFIVRGRLDSCTTNGGRTGFFNTCRIGSGDFCGEELLPWALDPRPTAVLPSSTRTVRAITEVEAFALIAEDLKFVAAQFRRLHSKQLRQTFRFYSHQWRTWAACFIQAAWFRYKRMKETNEVKEKENLMMMSNVKYYGNDDSQYFSAPLQVPKGSSYSMYSGKLVGSLRRGRSMRYGSELDMLGTLRKPIEPDFNDDGD
Protein: EG:BACR25B3.9 protein (Kinesin-like protein at 3A, isoform A) (Kinesin-like protein at 3A, isoform B (EC 5.6.1.3)) (Q9XZ29)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Fascetto
- Kinesin-like protein
- Aurora kinase B
- Sister of feo, isoform A
- Kinesin-like protein at 67A, isoform A
- Protein abnormal spindle
- Bub1-related kinase
- Kinesin-like protein Klp61F
- Inner centromere protein, isoform A
- Rac GTPase-activating protein 1
Sequence:
MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQCGDGDGQKDETEDADKSDDDGDDEPQTSKENAVKFVTPEAPGKVVASPKQTLQEPKAAATPLMNSNVVEDINGPKLAKMSGLAFDTPKRKFF
Protein: Alp1p (Q59WG4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSVEYPNSVTSLDKKPQVDLENVIEDASTSSEHRVAQTENLNRSLGARTINLICLGGVIGTGIFLGMGKMLSNAGPLGLLLNYLIMGSMIYFMMLSLGEMSVQYPISGSFAVYTKRFGSDSLAFATLFNYWLNDCVSVAADLVALQLVMQYWTNFHWYVISIIFWVFLLLLNVLHVRLYAEAEYSLALLKVVTIIIFFIVSIICNAGKNPQHEYIGFKYWSYGDAPFVDGIRGFSKVFASAAYSFGGLESVSLTAGETKNPTRVIPKTVQMTFFRVLIFYILTAFFIGMNIPYDYPNLLTKKVATSPFTIVFQMVGAKGAGSFMNAVIMTSIVSAGNHALYAGSRLAYNLSLHGYIPKIFLPMNRFRVPYVAVIITWLIGGLCFASAFVGSGELWSWLQAIVGLSNLISWWVIGVVSIRFRRGLEKQGRTHELLFKNWSYPYGPLYVVILGGFIILVQGWTTFSPFSVNDFFQSYLELGVFPLCFVFWWLVVRKGKDKFVKFEDMDFDTDRYYETPEEIEKNRYANSLKGWAKFKYNFADNFL
Protein: Protein melted (Q9VS24)
Organism: Drosophila melanogaster (Fruit fly)
Function: Participates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes. Involved in R8 photoreceptor subtype specification. During early embryonic development, may be required for ectodermal patterning.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16054033}; Peripheral membrane protein {ECO:0000269|PubMed:16054033}; Cytoplasmic side {ECO:0000269|PubMed:16054033}.
Interaction partners:
Sequence:
MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSSGGESIDVNQIRSVKVSRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKTNSLPARSIGSSKPSF
Protein: ADAM10 endopeptidase (EC 3.4.24.81) (Q9VAI2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Nicastrin
- Presenilin homolog
- Gamma-secretase subunit pen-2
- Furin-like protease 2
- Furin-like protease 1, isoforms 1/1-X/2
- Protein serrate
- Tyrosine-protein kinase
- Tissue inhibitor of metalloproteinase
- Suppressor of hairless protein
Sequence:
MSWLLGLLGLQVLFLWLLWLPGEILAIPTPLKLPGYTHRLTPYIKHWEAANFDRQVLQAAQVRHLEQARFRQKREVTPSASGLAHTIRLNFSAHDRDFRLVLRQQPHSVFAHDVEIENTLGPIDYDVSRIYTGSLEDDEAAHVQAILTSDNLLDGTIETQAEHYYIEPAHRYSQQLAESGVHSIVYKLSDVNMQKQQFTGGGLNSATPAKTHCASEKLRKKRWLPEELAMSDAPAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEESPRKYPTTSTTRSTVRSTESFLATLTKPTSNRNILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNSNNNVRKLYTKHKNIIVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTTLFLGNNNNGNDRPSHKTHVEIITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSMMMTNLLSGRGGEDIHSSPRLLYDRKTTCMLYLQADHTFFQKMGSDEASIEAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCFTEPQSSICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKFGDKCRDDNGCRDPSFCDGRVPQCPPSVNKPNKTICNKEFVCYMGDCTGSICLAYGLESCQCIPGPQDDRIKSCELCCKLPGEDSPCRSSFEWNEAPFDVPDMYSKPGTPCNDYNGYCDVFQKCREVDPSGPLATLRKLLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLAKRSNLKLKSVTIIHSATTETVRLPENNNGVIVHTAVRTKVPFKKKVRGERTKKPGTGAGVTAAAAVGTRNAAKSSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEIIDYSNRNNNGDDASNLSTTNNHTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKVMSKSQSTPERLVQKTPQKTKSMGNLSNEKVKLQVVYKPPFKFSLRLSKKPKVKTHVVGAGVRPKRSQKTSNRTGGQSSSKEVSTRAKRSALLLCNEAEDDNQILTLNEPNYETLKPPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTRNFGSTQNLINLSQNLSKNKKRSSLNLKASGSGATRSGKDPPTMGVASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNSRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATSSSSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTGTGAAAGKPGAAVTSAAATSAGASSAAASNENNELPSDLEVVVSDVENLVS
Protein: Sporulation-specific protein 75 (Q07798)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Required for spore wall assembly and ascus formation.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MNATKELTFNLLNKFQDKERFGSAQRHAGISLKGFISGILFSFLYFLFQLSLFIILRSRFKTIYQANVVLKIHPGSKVCFAKKKIKNYWSLFAFLKQLPGRMLDPMEKFERNERYGLDNYLFLRFLKLLIFFFAVLSIINIPILIPIHYFSRDILKENEGERYEQSFRTTSKLDKWTMSNLSPNSSNTLICHLFLSIFVVLWFHFILSSELRFVNRLGYSVLTKSKYQNILYLEGFSSKLVTQSISLETFFQPLHSDCFGVTHFIPKNLKKVHKLEIKLNKLQKSKEQIIFEIILEKYFRRVSIHRHLIANHKRFFFSKLKNHLLFQYKKLVFLTQFRISYYCTKIRLRWKKSSIFPLYYPKLYVNTETILERKYRILDKIIRKEKLIKFQVNSLKATSETKQALPDDLSSGTDIYMDKMFITFKSTLLSNVIGELLSYRLPTQNLKVIIGPNVNDIIWRNILDSSPLWKSAKYFSANILRIFVIIGWILPVAFLGLISQIPNISSLIPFTKIIHFQSPFIREVAKNLIPIVTLIIIIEIVPYFFRWLSYLRGLKTGAQIEADVQNWYFVFVFIHLFVVVTISSGFSIIIERLLNNPVSIPALLANDLPKCANFFCSFVLIRGMAYAGGNLLRIKELLFELFYYKWKRSTPHAQFKRLKTSLFFQLGSIYPIFSVLGCIGIIYSVVAPIILLLCCISFSMVFFSFSYLFKYQYNKENYSETFGKLYIQALMQLYAGIYFMEFCLLGLFTLFDQYTLSTIMLVVFALTVITHSKISKQIKSKPQRIPTLEYLSNLTEERKDQFCQESYTFHDIFSICRNSDEIWLPRDKLGISEEEQSFLEKSYHLKFDLNMYSMNLFGDCHLENSHLH
Protein: POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1) (Octamer-binding protein 8) (Oct-8) (Octamer-binding transcription factor 8) (OTF-8) (P31361)
Organism: Mus musculus (Mouse)
Function: Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3').
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:10473120}.
Interaction partners:
- Histone-lysine N-methyltransferase EZH2
- Transcription factor SOX-11
Sequence:
MATAASNPYLPGNSLLTAGSIVHSDAAGAGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGREDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ
Protein: Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) (Q9UIG8)
Organism: Homo sapiens (Human)
Function: Mediates the Na(+)-independent transport of organic anions such as prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin. Also displays a low transport activity of estrone 3-sulfate. Shows a pH-sensitive substrate specificity towards T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
Subcellular location: [Isoform 1]: Basolateral cell membrane {ECO:0000269|PubMed:16971491}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basolateral membrane of choroid plexus epithelium. {ECO:0000269|PubMed:16971491}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:16971491}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651). Localized to the apical membrane of choroid plexus epithelium (PubMed:16971491). {ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:35307651}.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
Sequence:
MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL
Protein: Neuron-glia cell adhesion molecule (Ng-CAM) (Q90933)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MALPHGLGLLLLLLLGGPGAAITIPPEYGAHDFLQPPELTEEPPEQLVVFPSDDIVLKCVATGNPPVQYRWSREDQPFVPEEHGGVSVVPGSGTLVINATLAARLQGRFRCFATNALGTAVSPEANVIAENTPQWPEKKVTPVEVEEGDPVVLPCDPPESAVPPKIYWLNSDIVHIAQDERVSMGQDGNLYFSNAMVGDSHPDYICHAHFLGPRTIIQKEPLDLRVAPSNAVRSRRPRLLLPRDPQTTTIALRGGSVVLECIAEGLPTPWVRWRRLNGPLPTRAALENFNKTLRLWGVTESDDGEYECVAENGRGTARGTHSVTVEAAPYWVRRPQSGVFGPGETARLDCEVGGKPRPQIQWSINGVPIDALPGAERRWLRGGALVLPELRPNDSAVLQCEARNRHGRLLANAFLHVVELPVRMLTADEQRYEVVENQTVFLHCRTFGAPAPNVEWLTPTLEPALQDDRSFVFTNGSLRLSAVRGGDGGVYTCMAQNAHSNGSLTALLEVRAPTRISAPPRSATAKKGETVTFHCGATFDPAVTPGELRWLRGGQPLPDDPRYSVAAETLTVSNVDYGDEGTIQCRASTPLDSAEAEAQLRVVGRPGPIRDLQVMEVDEHRVRLSWTPGDDHNSPIEKFVVKEEEGIFSAGRFAERLTVPGGQPWTPPLPLSPYGRFRFRVVAVNAYGRGEHSAPSAPIETPPAAPERNPGGVHGEGNETGNLVITWEPLPPQAWNAPWVRYRVQWRPLEEPGGGGPSGGFPWAESTVDAPPVVVGGLPPFSPFQIRVQAVNGAGKGPEATPGVGHSGEDLPLVYPENVGVELLNSSTVRVRWTLGGGPKELRGRLRGFRVLYWRLGWVGERSRRQAPPDPPQIPQSPAEDPPPFPPVALTVGGDARGALLGGLRPWSRYQLRVLVFNGRGDGPPSEPIAFETPEGVPGPPEELRVERLDDTALSVHWKRPRHLNGVLTGYVLRYQQVEPALGLPQEAPYPPGTLNATLRGLNARSRYRLALRASTRVGSGPALQTVGSTKPEPALPALERVLVSEVGEDFTVLLWSLVQPQEDDVEFEVQFMNKSTDEPWRTSGRANSSLRRYRLEGLRPGTAYRVQFVGRNRSGENVAFWESEVQTNGTVVRSLVGGFATKGWFIGFVSSVVLLLLILLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESEAEEKGSASGSGAGSGVGSPGRGPCAAGSEDSLAGYGGSGDVQFNEDGSFIGQYRGPGAGPGSSGPASPCAGPPLD
Protein: ADP-ribosylation factor (Q9M1P5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555, ECO:0000256|RuleBase:RU369003}.
Interaction partners:
- Ras-related protein RABH1e
- Kinesin-like protein KIN-14E
- Ras-related protein RABA5e
- Ras-related protein RABG3d
- Ras-related protein RABA1d
- Ras-related protein RABA1f
- VAN3-binding protein
- Ran-binding protein 1 homolog b
- Golgin
- Coatomer subunit gamma
Sequence:
MGLSFGKLFSKLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIANKA
Protein: Cytochrome P450 (Q9LUD3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Gibberellic acid methyltransferase 1
- Protein HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 244
Sequence:
MSFSVVAALPVLVAVVVLWTWRIVKWVWIKPKMLESSLKRQGLTGTPYTPLVGDIKRNVDMMMEARSKPINVTDDITPRLLPLALKMLNSHGKTFFIWIGPLPTIVITNPEQIKEVFNKVNDFEKASTFPLIRLLAGGLASYKGDKWASHRRIINPAFHLEKIKNMIPAFYHCCSEVVCQWEKLFTDKESPLEVDVWPWLVNMTADVISHTAFGSSYKEGQRIFQLQGELAELIAQAFKKSYIPGSRFYPTKSNRRMKAIDREVDVILRGIVSKREKAREAGEPANDDLLGILLESNSEESQGNGMSVEDVMKECKLFYFAGQETTSVLLVWTMVLLSHHQDWQARAREEVMQVLGENNKPDMESLNNLKVMTMIFNEVLRLYPPVAQLKRVVNKEMKLGELTLPAGIQIYLPTILVQRDTELWGDDAADFKPERFRDGLSKATKNQVSFFPFGWGPRICIGQNFAMLEAKMAMALILQKFSFELSPSYVHAPQTVMTTRPQFGAHLILHKL
Protein: SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap) (Q9QXY2)
Organism: Rattus norvegicus (Rat)
Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22673903}. Cell projection, axon. Cell projection, dendrite {ECO:0000269|PubMed:19146815}. Presynapse {ECO:0000269|PubMed:18662323}. Postsynapse {ECO:0000269|PubMed:18662323, ECO:0000269|PubMed:19146815}. Postsynaptic density {ECO:0000269|PubMed:19146815}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000269|PubMed:18662323, ECO:0000269|PubMed:19146815, ECO:0000269|PubMed:22673903}.
Interaction partners:
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- Microtubule-associated protein RP/EB family member 3
- Disks large homolog 4
Sequence:
MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTSQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSPQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLAQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGTPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKLRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQGPAGSPDKGKHGKQRTEYMRIQAQQQVRVGYQAPRPLEGCTPRLCYMPLS
Protein: mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) (Q4QBG5)
Organism: Leishmania major
Interaction partners:
- Phosphomannomutase
- Putative dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- Putative elongation initiation factor 2 alpha subunit
- Translation initiation factor-like protein
- Dolichol phosphate-mannose biosynthesis regulatory protein
- mannose-6-phosphate isomerase
- inorganic diphosphatase
- inorganic diphosphatase
- Glucose-6-phosphate isomerase
Sequence:
MSSSDGQGMRAVILVGGFGTRLRPLTLTTPKPLVPFCNKPMIIHQIEALKAVGVTEVILAVAYRPEAMKEQMDEWSRKLGVLFVFSVEEEPLGTAGPLALARDILMQDDKPFFVLNSDVTCPFPMQELLDFHKAHGGEGTIMVSQVTQWEKYGVVVYSPQNYQIERFVEKPSSFLGDRINAGIYIFNKSILDRIPPCRTSIEKEIFPSMAAEGQLYAFNLEGFWMDIGQPKDYILGMTKYIPFLVHSNRETEKLHTEATKHQRGGRFTVIGASLIDPSAKIGDGAVIGPYASIGANCVIGESCRIDNAAILENSKVGKGSMVSRSIVGWNNRIGSWCHIKDISVLGDDVEVEDGVVLIGTKVLPNKDVGEHHFEPGIIM
Protein: 2'-5' oligoadenylate synthase (EC 2.7.7.84) (S4R3A5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLTQHTPGSIHPTGRRGLDLHHPLNASASWGKGLQCYLDQFLHFQVNLTLVGRRNYTNN