wanglab/gogpt-training-data huggingface dataset:
Protein: CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B) (Q96LI5)
Organism: Homo sapiens (Human)
Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}. Nucleus {ECO:0000269|PubMed:21233283}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:21233283}.
Interaction partners:
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 6
- CCR4-NOT transcription complex subunit 8
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 11
- 182 kDa tankyrase-1-binding protein
Sequence:
MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR
Protein: Uncharacterized protein (A0A178V0E5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSSIARDRKEQMVIHSSIVLLQERFRQLQRARELRAERELLNPKPNHQDNILQYYSEPTSFGFFQFLPINSQTSSSQQLLSLSLCSHSTSESIEKPSFCHQWPNKDDKKMGGIDRYDDVDTSLHL
Protein: Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) (A2A3K4)
Organism: Homo sapiens (Human)
Function: May play roles in cilia formation and/or maintenance.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Sequence:
MAAGVLPQNEQPYSTLVNNSECVANMKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL
Protein: DOCK family protein (Q54CA8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- AP-3 complex subunit delta
Sequence:
MDTSSMSNNSHSTSAATTSKMVGSTTNNSTSSVSVSQSPIGASQQFGQPITSPNPNSNNNNPTSGSTPILSNTSNNVNVSPITPSSNNTDKKKSRIDIEYKFEDYEDSFFTKAIINDPLKISVIPDLLSLTTEKRVTNLVGNNVPTEVTSIMDKLPKGVQESLNIFNQDWTVVTRDPLPPPSNSQPLKPLQSQNYSVDGEFDSISPTDSVKDLNPDIIAISTQPTPDQKSIEFMKSPNRIPLFQTCYINDESPTINPPKVGKKILENIEFQFKVECTDFKPQIGNFEPFFGRMFIFDANKVDDSDSKSPEVGIISEEFHFDLGTNLDLLPKNSQVNSLNQINPLDNQLPTKIQKCIFSCEKSSDLYLVICFDKVILGDPEETTKHYFNPPKAKELTKIQSEVKEGVSRLGKFKQPFIWGCVELFDQNRKFNFDQGEAEIRVTNFIKAKSDQLYSFVSKEKKSSSSAASKDPLFECILKILQVSSSIGDDKYLYNENVNGRVDYLLRTKIPNTLPPQIQSGQDGKGIIKEILHFNSKISCSASGDSLILKDRDGDKNDFTNNSISNSIGGGGGNNTNGGGSSNNNSGVNNNSSNGIDYHHNNSNNNSNNNNNNNNNHHTDNSCNEELILKSKEPHLTFSNVLYFYPKSVNLTNFKSDRGSARNIFLEVKLMEDDSSVTAIGMKNTHGTSTTPLLTCSFLTSVVYHNKKPKFSDEIKINLPSNLTANHHLLVTFYHLGCKKSKKSENPMHTPLGYSVVRLFEQDRIICDGKYKRPVGTVFPPRYLAQEAKDIKDSKDTINHKIWVDNKKPVFSFKTRVISSLYPQDPTLAYLLKESIESNHTLLNENIKKLPSVPNTLKTQFFPSIIRLLFKSITSLSAEVSANSFNVLLNLLDSVPEDVLTSYITYVFNSENSHSFSLYDNIIQVWNQLLEGNSASTTSSSTITITTTPIVQSPPPASSTSSSSLQNSSTTNLTPPTPTPTPSSSSSSSSTTQTIPNPNQLRQDDLILLSIQYSWFLFGIIKKSMIADIQNRDQLKSGRNRTNRFSEEILNRFSFLFDQLLVQLKGAKQLVAKVLIVNIGHFINDLLDIMSRGFVFRIIRNYIAGLDCSNTVMELTELKSRLFRVLASNDSFIALNSPAPISPFPSIQDLFQVFYRKHFIIGLMLQEVSAVIPARDKEMRLKVINTLREIISKIDTNPLYNSPAMRERIAALFFPLLPIIVYHYDAYISKFDQEEQRSWLTCFIYIVKNLNNTNTISDWWKKETPRNNVIFFQILTNCLSIFDYAKEYNQKDDDLESSSKSIQTHQSNLSLDANTDSPGKKKEKPSKSSVKQNVSNIKPDKAKQMIEQQLASSTGMKNSMNSPSQTSNNKENIGNLNANSNSINGSQSPLLNVNKDTSNVLGQSTGSAYSQQSPNPGLRAFASSVTFLTVDFTQGSTTQETIQMMYGNLCQEVTLTVLNAFTVFIREFKSDLLKGTTVAYTDHILFRVILQLLKQDLSFSVIKPVFSVLATLVGEFKHVLFKQNNSICENLTQLVFKYCCSRHSPSRQYATTLIYLMIYNNLKEMGHFSRMKLHSTVAISQILNEIVEKNVQTESVEIVFSYLYACLDSIAKFVKQNCNNSLLKTSYSTSVSSGNVKSTTTTTSTSRPSIGSQQSSNGATRTQPTIAQQIDELKERLFGVIKNNVKIMQHSYDPEMKADLYYNLSNTFIESPDLRITLLKSFKEFLKQQKSMEEAAQVSIIAAALVSGYLKLLNRFPKELLATDFTTVSPNVANELTLPDLSLLEDVEGEICKLDHFTDTGFINLLKDAIQIQKSGYFESAAETYRLLLPTYQHQKDWTKQRDAYQELVLLCNQIISENVVNQRIFSNYYRVAFYCQDLIPDLHGKEFVYKENNYVRLSDLSERLKKQYCDKFGEDKFHLLPNNKPVDLSSLDVKHIYIQIISVDPYLLPEELKERTTPFQQNTHLNKFIFEIPFTKNGKTQYSENVTEQWKKKIILTTPNYFPYLKKRLPIVKKEEIELTPIEASIELIQKKVTILKAELNSRPANTKTLQIHLQGCLLLQVNAGPLAICSSFLAEGQYQNHNAEHIQKLSEVIKEFSKTLDFGLKFNASLTKEDGAELQKQLDSGYDNFRKKLQEYVKLGNDYDDF
Protein: Homocysteine S-methyltransferase 1 (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase 1) (SMM:Hcy S-methyltransferase 1) (Q12525)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Also converts S-methylmethionine (SMM) to methionine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Cystathionine beta-lyase
- S-adenosylmethionine synthase 1
- Cystathionine gamma-synthase
- Adenosylhomocysteinase
- S-adenosylmethionine synthase 2
- Putative cystathionine beta-lyase
- Homocysteine/cysteine synthase
- Putative cystathionine gamma-synthase YML082W
- Cystathionine beta-synthase
Sequence:
MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS
Protein: Sestrin-3 (F1R1P4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- GATOR2 complex protein MIOS
- GATOR2 complex protein WDR24
Sequence:
MNGTAGICNHCRNTIREKEKMSRHISTGPSSFIPENEIIGAMPLSDSTVMLLDEEFSGRMDNLTQVMGLHPHYLQAFLRCHYYLLRMDGPLPLHYRHYIAIMAAARHQCSTLVCHHVQEFEQIGVCSDWLRGLEFCPQRLRNLNEINKILAHRPWLITKQHIQALVKTGEHSWSLAELVHAVVLLAHFHALASFVFGSGVNPDPEVTEVNGVTGDLCPPVMKGLCTCHLTNSNQANGNPNTGSELEALMERMKRLLEEREDDDASEEEMFTRFEKEKKESLLVVSAGFDEEVVPPSPVARFVDDPSFGYQDFARHGEDNPPTFKAQDYSWEDHGFSLVNRLYSDIGHLLDDKFRTACDLTYYNMASHEGVDTSMLRRALFNYVHCMYGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTCRMYESYWHQFRHSEKVHVNLLLMEARMQAELLYALRAITHYMT
Protein: FI18839p1 (Trio, isoform E) (Q8IRI4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSCFFRLFASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQYFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQGPMNCVVDAAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGDCRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPLSTKNK
Protein: OTU domain-containing protein (Q57W52)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSAIKELVERKVKRGPYAHHELIICPGYSNTGNASTNTKGSAAASDTRSNSLPGVGSKGHRCWLCASLVKPIEPQEVLLCFRCLRVAFLDIIMPLVDSPERRKADAKFISKISRVKDTEGTTPLVPKLPTVVSATPPAANEVQSTNHVSQSRSTLPSDPSGRTQLANDSGLGRGVDSHRCSSAWAHRRCIEVGDQGTPAGNGHDELTVKCPVCHATCSATDKRLTRCLDGKTVHLIWVCSMCNTTNTQNSDECHSCKAPFVWPCLQCGLTQESPCCGDELRMCVECEALNTPADILASLKRACLGGEGGYAETDGDLGLDDEGNDGTAGDADLVGSVFGVNDLDTVAEKARQREIVEGRARLQRRMRRLGVEANVQESDGNCLFRSLATQLLGDPGAHMTIRRLVVGYMKVRQESYKILFDGEEEWSNYISNMYCSGSWGDELCLNAACRCFRVNIHVITSAASGWHLVFQCDDLQDSATAPYGDSGQGRLFETAGSICLFLNYIAPVHYDDVPVFRSQVISLNAKLTEQLQYMLAEEGRSRSRRDDARRSGAVRVGQLQSCPSIGGEGQPLQKLEEQGQRCAKQQLESDENSACCVDGKVQQRMDAKLPLQLSGEQRQKTDEKYLTDTCRDRPRLINEGSPRPATGHPHRACNDHTVRQMNTHKQWRTGEEMSRDVDEGRLWLANSETLSQGTGDRQRGMGEHPKRLMNEEIMRQVNGQQQQQWVNEGHRRPLDEKYLTDTCRDRPRLMNEGSPRPATGHPHRACNDHTVRQMNTHKQWRTSEEMSRDVDEGRLWRMNPLSLHRGGEVQQPDHSRDHQPRAHGLPQRAGRLHDPHTPREQSVSGQQHRQWVLPPPAPGCNNEFTLPIPSRPNTMRQFRESRPSTLSSDSAVASTGLFPRPNGQNWPLGDLRGPH
Protein: Aspartyl beta-hydroxylase variant 1 (Aspartyl beta-hydroxylase, isoform A (EC 1.14.11.16)) (Q9GQ82)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGDVQPRKRKDKRRKRDDDESSHGVHITKMGNEDLHLHVHHDHGTGGHWCAKIIFFALMAVLLGLVGLIIMENRGLEDLDTPLSESRFSKVFDGWVDEHRDEHDGHDVQEPSGEALDDHDEHDDHDDHEDEDEEPLTEELEEELEEEEEPTEEDEPAADEEYEEDEDEENNAGENITAEDAEEEEEEEDNDDEGTVEATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEESVEPERSQYAAQSAPAKDNNDDDDDDDQDKNDADDGDDDEFESLAQQFENDPEDTVPAKAVESEEQDQDQADEEEPKEEGSSWLASQIKPKEAAPAPAEKEDPFEQELRKANEEMIRENYAQALRSFNTLTTNFAHEPSAHLGRARLLELLAKKERSNQRLWEAIDAYKRYLAFGELVASNQEFQTAGESCIENLRFLGHHRQATTIHELLINRLPEDPRLRNQLSLTYLMVNNLQQVEKVAVETLKLWPNNAVAQLHYGLALRQFHADYAKALPYLKYAVESGEEGTQEAFFYLSLGETMQRLSMKSEALEVYGKGVAKGFFASLYQRSLYNEPRLRAQPFWQPKETGYERQLEKLTLNWRAIRDEGLALLGRSGFFEDEAELLRDKGVWQQYELYAQGRRVKDNCRRAPITCSLLEEFPESAGCRRGQVKFSVMQAKTHVWPHCGPTNCRLRAHLTLAAPEPEKASLRVAEQERTWREGELFIFDDSFEHEVWHNGSQSRLVLILDMWHPQLSAAQRRSLSPI
Protein: L-threonine 3-dehydrogenase (TDH) (EC 1.1.1.103) (L-threonine dehydrogenase) (Q5JI69)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of L-serine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00627}.
Interaction partners:
- 2-amino-3-oxobutyrate coenzyme A ligase
- Threonine synthase
- Threonine synthase
- Cytidylyltransferase
- Glyoxylate reductase
- D-3-phosphoglycerate dehydrogenase
- Cystathionine gamma-synthase
- D-isomer specific 2-hydroxyacid dehydrogenase
- Oxidoreductase, aldo/keto reductase family
- Cysteine synthase
Sequence:
MAEKMQAIMKTKPAYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEDLQVGDYISVETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAHYAIVPAKNAWKNPKDMPPEYAALQEPLGNAVDTVLAGPIAGRSTLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRKLAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVFLEFSGAPKALEQGLKAVTPGGRVSLLGLFPREVTIDFNNLIIFKALEVHGITGRHLWETWYTVSSLIQSGKLNLDPIITHKYKGFDKFEEAFELMRAGKTGKVVFFPHKG
Protein: Peptidoglycan endopeptidase RipB (EC 3.4.-.-) (Macrophage invasion and intracellular persistence protein B) (Resuscitation-promoting factor interaction partner B) (Rpf-interacting protein B) (P9WHU5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion.
Interaction partners:
- Peptidoglycan endopeptidase RipA
- UPF0353 protein Rv1481
- Possible Inv protein
- Chaperone MoxR1
- Possible conserved transmembrane alanine and glycine rich protein
- Probable peptidoglycan glycosyltransferase FtsW
- Exported repetitive protein
- Esterase/beta-lactamase LipL
- Conserved hypothetical proline and threonine rich protein
- Resuscitation-promoting factor RpfB
Sequence:
MRHTRFHPIKLAWITAVVAGLMVGVATPADAEPGQWDPTLPALVSAGAPGDPLAVANASLQATAQATQTTLDLGRQFLGGLGINLGGPAASAPSAATTGASRIPRANARQAVEYVIRRAGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLVRYAFAGVGVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGGQHVTLYLGNGQMLEASGSAGKVTVSPVRKAGMTPFVTRIIEY
Protein: Putative sphingomyelin phosphodiesterase asm-3 (EC 3.1.4.12) (Q9UAY4)
Organism: Caenorhabditis elegans
Function: Converts sphingomyelin to ceramide.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q10916}.
Interaction partners:
- Probable ceramide synthase lagr-1
- Ceramide synthase hyl-2
- Acid ceramidase
- Ceramide synthase hyl-1
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Ceramide glucosyltransferase 2
- Putative neutral sphingomyelinase
- Sphingomyelin phosphodiesterase 2
- Ceramide glucosyltransferase 1
- Alkaline ceramidase
Sequence:
MLLGLLVLSLAFQGTLAVTECEECKSIVDLLQFEWGEKKTEECVMEIAVFICETFHIEDNDVCNFIISDFSDEFMYVIKQILVTPHQLCGLLMKNDCGDFVDPLATIWNMTIPGNQPPFVPKQVVPPGNPTLRALHLTDLHVDMFYTVGLEADCGTPQCCRPQDMNVEIVENGDVKQPAGPWGSVGSCDTPYWLLTNMLQNIASTAGKLDYIMVSGDLVSHTVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEYNGCYMKKIYDGLRMISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYYKIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDYFPAYRIYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNVKWEVLYQSANMEYGLKGQIPTEYNQMIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQTQQLCTDLEGGIQKPEPKKNKYSARFATSNERRRGKEECKI
Protein: Putative cytochrome c biosynthesis ccmC-like mitochondrial protein (Q8HCQ6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion membrane {ECO:0000256|RuleBase:RU364092}.
Interaction partners:
- Cytochrome c biogenesis Fn
- Cytochrome c biogenesis B
- Cytochrome c biogenesis Fc
- NADH-ubiquinone oxidoreductase chain 3
- ATP synthase subunit 9, mitochondrial
- NADH-ubiquinone oxidoreductase chain 6
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
- Maturase-related protein
- ATP synthase subunit a
Sequence:
MSVSLLQPYFFMSKTKSYAQILIGSWLFLTAMAIYLSLWVAPPDLQQGGNSRILYVHVPVAWMSIVIYIATAINSFLFLLTKHPLFLRSSGTGTEIGAFFTLFTLVTGGFWGRPMWGTFWVWDARLTSVFILFFIYLGALCFQKLSVELASILICVGLIDIPIIKFSVNWWNTLHQPGSISRFGTSIHVSMLIPILSNFANFLFFTCILFVLETRLLILSFLESSLTEEIEAREGIPLKT
Protein: Protein FAM184A (Q8NB25)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:33957083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to cytoplasmic foci in both interphase and mitotic cells. {ECO:0000269|PubMed:33957083}.
Interaction partners:
- DnaJ homolog subfamily C member 27
Sequence:
MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF
Protein: Reducing-end xylose-releasing exo-oligoxylanase Rex8A (Rex) (EC 3.2.1.156) (A0A0S2UQQ5)
Organism: Paenibacillus barcinonensis
Function: Involved in depolymerization of xylan, a major component of the lignocellulosic substrates. Acts as an exo-oligoxylanase that efficiently hydrolyzes xylooligosaccharides, releasing xylose from their reducing ends. Hydrolyzes xylooligomers of 3 to 6 xylose units to xylose and xylobiose. Besides linear xylooligosaccharides, also hydrolyzes branched xylooligomers, such as xylooligomers decorated with 4-O-methyl-D-glucuronic acid moieties. Its proposed role is the degradation of xylooligomers produced by the activity of extracellular xylanases once they have been transported inside cells. Shows minor activity on polymeric xylan (glucuronoxylan from beechwood). Is not active on cellooligosaccharides or cellulosic substrates, or on other polysaccharides such as pectin, polygalacturonic acid, laminarin, or lichenan.
Interaction partners:
Sequence:
MNITGKGAYDTGTYANLFQRSGYREDEIKARLEQTWNDLFYGDEHTRIYYPVGDDKGYMLDTGNDDVRSEGMSYGMMMAVQMDKKHEFDRLWNYAYTYMQHTEGRYKDYFAWHCKPDGTRLSPGPAPDGEEFFAMALFFASNRWGDGPAPYDYQAQARKILHACLHQGEQGEGDPMWEPSNRLIKFIPELPFSDPSYHLPHFYELFAQYANEQDRTFWKEAAEASRAYLRTACHPVTGLSPEYANYDGTPAPVQLHGDFRHFYSDAYRVAANVALDWEWFRKDPWQVQQSNRIQAFFSDIDVSDYRRYTIEGEPFNEPALHPVGLLATNAMASLAADGPDADSFVKRFWNTPLRQGKRRYYDNCLYFFTMLALSGNYRVY
Protein: U6 snRNA-associated Sm-like protein LSm3 (Q9U1W8)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365046}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm8
- Probable U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm1
- Probable small nuclear ribonucleoprotein Sm D1
- Probable small nuclear ribonucleoprotein Sm D2
- Probable small nuclear ribonucleoprotein G
Sequence:
MATEKKEVTLSATVEEPLDLLRLSLDERVYVKMRNDRELRGRLRAFDQHLNMVLSEVEETITTREVDEDTFEEIYKQTKRVVPMLFVRGDSVILVSPPIRAS
Protein: AT10293p (Q86NN0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Interaction partners:
Sequence:
QVDYERLRKATERLEGLAGDLHNREQLIDELKGAAKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRAVELWDKYRNASAAVKNSIDQQMDAVKSLEQPLDALQHAKVCQDNLTTQNDRILELRDIVAKIAADVGLDASALMQGELDALGQRLAECKDAITTLANVAETQDKERKELDKEVTLAKAYFNNVQQDISREAPQNPKESEEQLAALRAHLQTLARTEEQLRQLKERHQNSEVAPSVASSDDDGILEVLALWQKIFQDTFQEYHRLSTRLARSQNSSEALRLWRQYLQHVQSFLSCAIPEDYSSLREQQQLCAIHQNLLISQQSVLSETPLESELSEQYKALTNLHNETLSRIMQRNGELERRVSGWNAYRQQLAALLDWLRQREAERNALQLRYIHLKRVPHLKHRLDAMIQQLDQGEQQSKALQEQQQELARHCDDALATAMRMEQASIGQRISNLRAALKTWQGFLQRVTQLSESYEQRVNQLQQEFGAAQKLLDANSESLPTQPAAIEQLLGSLRAQRVQLGAQVSALESLTVTQEELKECISPHDMKTIRQRNWLLWQQHADLDYQLANLINSIEERLSLLSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPEQAAKQLEQQVNSELQLRDKEREWLLSTSRELLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAWLFEVESQLDKPLNFESYTPNVIEAKIKEHEQIQRSIEHHSSNVGEVLNLVEMLLNDADSWRTQVNTSGLAASAQNLEQRWKNVCSQSAERKARILTIWNLLQQLIKLTAEHKNWLGKQESQIAGFERDQKSHSKHKLEERQKELRAKLEELESQSVNLRQLEQIYAKLTMSAGVEPENIQKLTLPTKVMVSMWRQLTPRCHALLDAIDKDAKLMREFNNAQLEATNSLNAIQKALEQLPSAEDQQTSKAEPKAVLQRLESLEKKLQDARQHVQQADNLAQEAKTRTKQQPQLKQLLELVSAYTTLWQTVQTRIVTLKTTWLTRAAQAAASLPVSEAANAAVQVNTLSQRKLRQAQQMQRETSITAKDAYIMELQTAITECQNNLDELQRTVVDKTRKPGPQKIAKLLGNAQSSTELVKHLSHLLLTECKADDQAAEVDTVAELTLRFDTLQSQWKARQQHDQNASEVGRLTCPLCTQRNWQQIDNDLWRLEQWLQFAESTQKAQSAPPSNIELLEDVTQDHREFLLDLESHKSIISSLNVVGDHLATHTLDTEKARQLRSRLEADNERWNNVCINATKWQGLLQTALMGNSEFHQTIGELVEWLQRTEQNIKASEPVDLTEERSVLETKFKKFKDLRAELERCEPRVVSLQDAADQLLRSVEGSEQQSQHTYERLTDLRLRLQSLRRLSGIYIVKLGAVLGYEGDNLGVPLHMLSSELLDNTTLSTSSMQAAAPNTENANNTDGGDAVDGDVINTTVLARGARFLGRVARASLPIQALMLLLLGVATLVPHGEDYTCMFSNTFARSLEPMLSYPHGPPPT
Protein: Frizzled-4 (dFz4) (Q9NBW1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Low-density lipoprotein receptor-related protein
- Segment polarity protein dishevelled
- Protein Wnt-5
- Wnt inhibitor of Dorsal protein
- Tyrosine-protein kinase Drl
- Tyrosine-protein kinase transmembrane receptor Ror
- Tyrosine-protein kinase Dnt
- Dally-like, isoform A
- Protein Wnt
- Protein wingless
Sequence:
MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSISLNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHNHQHHSTSSHRLYYPPGSYASQKYSQHGSYYPHLQQYGNETLL
Protein: Syncrip, isoform N (Syncrip, isoform P) (A0A0B4KGF9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAEGNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKEFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLDNHEIKPGKCLKINISVPNLRLFVGNIPKSKGKDEILEEFGKLTAGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGNLSPTHPSIMSLTPMRPGARMPLRTPIPREYDYFYDFFGFSDYRQGGSFGNNVSYYDDMYRWIDGDYNYYDYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSASPSLMGVGRGHGITVPRGRVVGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPAATGGFRGVLPTRPSARGTQHVKPLQNLPAGAAFKTFMEGN