Protein: Condensin complex subunit dpy-26 (G5EGE9)
Organism: Caenorhabditis elegans
Function: Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners. Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Plays a role in robust cytokinesis upon presence of chromatin obstructions. Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization. As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites.
Subcellular location: Nucleus {ECO:0000269|PubMed:11937488, ECO:0000269|PubMed:18198337, ECO:0000269|PubMed:8939869}. Chromosome {ECO:0000269|PubMed:11937488, ECO:0000269|PubMed:18198337, ECO:0000269|PubMed:8939869}. Note=During meiosis and mitosis, localizes to condensed chromosomes (PubMed:8939869). In interphase cells, diffusely distributed in nuclei of hermaphrodite embryos prior to the onset of dosage compensation (PubMed:8939869). Localizes to the X chromosome after the 40-cell stage when dosage compensation is initiated in hermaphrodite (XX) but not in male (X0) embryos, where it remains diffusely nuclear (PubMed:18198337, PubMed:8939869). {ECO:0000269|PubMed:18198337, ECO:0000269|PubMed:8939869}.
Interaction partners:
- Condensin complex subunit capg-1
- Chromosome condensation protein dpy-27
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein 4
- Lysine-specific demethylase 9
- Zinc finger protein sdc-3
- Condensin-2 complex subunit hcp-6
- Condensin-2 complex subunit kle-2
- Sex determination and dosage compensation protein sdc-2
Sequence:
MDVPSSSNVTGRRKRQVLDDDEDDGFRSTPLRKVRGTKKIRPADVVPETIMTKIGAHIDDIVNKKKVGELNCFEYKSPLEIHTIEDMIKAKASIQEMAVVLEGAQCIIGYRVDRLHHDVRQIDSALSSGTVMRDSNGEEIHLTLESRKAKKKMAVVDGMNGMLDFLNNMDDALTTTELDADNDKNWKEDEENIAGEPRIDFKANSKDVDAFLQRDIFPEKLIYALSIKRATDLRADLLSDVSNYISADDTAHDLKDANIDWLRANPTFQKATKGSVCNSSNSFHSLNYYGIHSPDGRTLMLHNRIADKNADDRFFTSDVSVSLVKNTRALLTNSLDKKPRILDNYLMLEVKDRPVIGRYKIMSKDVKKSTLPLAESSREKDLANLTFAEMNHRPSNLDMTVAGASDMSMLPGNQGLPLAQGENDETIALDRLTPPLQSSVSQKASDEYVLPPLEANDLDEHLIGKLPIEPNEMDQTLANMFDKKLEVFNTSDTLESKVWKNGIRAEEWGEDDEAIMKNDTKHPRQAGIEGWIKATDAWTNYDVVKMNVNREARSQLDENAIDEQESYRNMVPEIGKNLFLVKSDDYMNNYPGDRPADFTVNDEVSDVMKMWSGEDSTAEDDVPLEQIQQEIREQVQQQDVDMEPIEEMDYDAGGAAFDVDFDDRLAAPVEVEEMEGDNNRNDGRVADILFNEQMDETEVEERNEQDVQRELEDIALAADEVAELMTSAPPPQLVGPSAEMREEIQNIGKNDNAHWVPPVVGDQERQAAVTAQRKRREKKAKSRKATVEDFVHYFRDIPDDEIEREITAAKCSKIADEKSTFLSEQQLYLPTLGIENKPHVAFEMGLLGNSGMFFKKSYGKIRLERVKNQKAEQDLFIDEARGNKDSDCLNWLLSFSGFRCMENPEPITGSDSDENLRTAVEQPFDDDFANDYYDEDRYDPNYEQQLAAAQMGPDMQRKLALTASHINQMFPNIHSKRYGGEYGDSDDEFDDSFDRQSIQAKNLDAAKHKKCLAEILKTDSLSMPSIQYVLEQLTSNQTLRMNNTTIRAADDRNETGRPATPTMEADKTLTSVFDYRSPNKSNHDVNETMKALTEMPDYQAADERPNNQPTTSTYGTANTENRKVHINGCHTLLSLALSMPSRMGETVRPSSIVSFLLHIANENNLQIVQDRSKRSWMSDFIVLNSSESLPRGLKMGRIEDQDEFWKRTQDPDAIEGTASDANNVFSNLMRRPKAVPVRKGRGAGGQPTTSDLGAIVEEEEMEE