wanglab/gogpt-training-data huggingface dataset:
Protein: Dedicator of cytokinesis protein 4 (Q8N1I0)
Organism: Homo sapiens (Human)
Function: Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12628187}. Cell projection {ECO:0000269|PubMed:20679435}. Cytoplasm, cytosol {ECO:0000305|PubMed:20679435}. Note=Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. {ECO:0000269|PubMed:20679435}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL24
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein uL23
Sequence:
MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSILLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLPRKVSQL
Protein: Pirin-like protein 2 (PIRIN2) (Pirin-like protein At2g43120) (Q9ZW82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in susceptibility to the bacterial plant pathogen Ralstonia solanacearum. Stabilizes the xylem cysteine protease XCP2 by blocking its autolysis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24947605}. Nucleus {ECO:0000269|PubMed:24947605}.
Interaction partners:
- Cysteine protease XCP2
- Cysteine proteinase RD21A
- At5g07400
- AT1G56000 protein
- Zinc finger, C3HC4 type
- Spectrin beta chain, brain
- Probable cysteine protease RD21B
- AP-1 complex subunit gamma-2
- Protein EARLY STARVATION 1, chloroplastic
- Cysteine protease XCP1
Sequence:
MRAAINRANSLGGLFSFRFIRNIKSMSSSTSQDFVSRPVIKKVFAKLQKEGDGAVVRRGISRSEQKLLDPFLMLDEFSVSPPAGFPDHPHRGFETVTYVLEGGITHQDFKGHKGTIYAGDVQWMTAGRGIIHSEMPEEEVNKGLQLWINLSSNEKMIEPNYQELSHSDIPKAEQNGVEVKVIAGESMGIQSPVYTRTPTMFLDFTLQPGAQIHQNVPESWNAFAYILESGEGGGVFSSSNSSPIPAHSVVVFGPGNDGVSVWNKSSSKQLRFVLIAGEPIGEPVVQYGPFVMNTQAEIDMTIEDYHYGKNGFEMAKYWRSQ
Protein: Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen) (P24158)
Organism: Homo sapiens (Human)
Function: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Subcellular location: Cytoplasmic granule {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245, ECO:0000305|PubMed:17244676}. Secreted {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28240246}. Cell membrane {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}; Peripheral membrane protein {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}; Extracellular side {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}. Membrane raft {ECO:0000269|PubMed:21193407}; Peripheral membrane protein {ECO:0000269|PubMed:21193407}; Extracellular side {ECO:0000269|PubMed:21193407}. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:18462208, PubMed:2033050, PubMed:3198760, PubMed:7897245). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245}.
Interaction partners:
- Myeloperoxidase
- Azurocidin
- Neutrophil elastase
- Cathepsin G
- Interleukin-32
- CD177 antigen
- Cathelicidin antimicrobial peptide
- Lactotransferrin
- Lysozyme C
- Endothelial protein C receptor
Sequence:
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
Protein: FI17814p1 (Pollux, isoform C) (E1JJ52)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKTRLVSLTFRGSASVDPRYSASMLPWTINDIRSTESYTKLSVGIENGILESYNSDFELQFSHPLKHIVGMCRIIHKPQAKSIGNGFLQLKSSAGQTSSSSAVASSMGGAASSSLTGNGLRHTLTASTSYGSLSSSAACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTPLSPPSTASNSSGGSIFSRMGYRTTPPALSPLAQRQSYGVAITTAPCPQHMEEVAPATTMAVMPQEDVEEPQPMHPLSMVGGDVNVRFKGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAVRVAPVPVELAPPAATATTGRS
Protein: Disheveled-associated activator of morphogenesis 1 (Q8BPM0)
Organism: Mus musculus (Mouse)
Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:37189369}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y4D1}. Note=Perinuclear. Colocalizes with RHOA and KANK1 around centrosomes. {ECO:0000269|PubMed:28284839, ECO:0000269|PubMed:37189369}.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Transforming protein RhoA
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- RIKEN cDNA 4930544G11 gene
- Disheveled-associated activator of morphogenesis 2
- Rho guanine nucleotide exchange factor 19
- Profilin-4
- Profilin-1
- Rho guanine nucleotide exchange factor 11
Sequence:
MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSPGAPGGPFPSSGLGSLLPPPPPPLLSGGALPPPPPPLPPGGPPPPPGPPPLGGVLPPPGAPVSLTLKKKNIPQPTNALKSFNWSKLPENKLDGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVAEAKQENENMRKRKEEEERRARLEAQLKEQRERERKVRKAKESSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRISNQVTDSSRERPITKLNF
Protein: DNA helicase (EC 3.6.4.12) (Q381X2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PRP8 protein homologue
- PRP1 splicing factor N-terminal domain-containing protein
- Spliceosomal U5 snRNP-specific protein, putative
- Sm protein F
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Sm protein G
- Small nuclear ribonucleoprotein SmD1
- Sm protein B
- Uncharacterized protein
Sequence:
MVYRSLCVPVEYILLKFYCSLFIYSLLGFVLNSRLPTNTPQAVVLMPILCDCLGPLASYFPHTNFTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRLTLNTVGSDAALPPNADDEVDAASGNKEYANSPTNRKAVYICPMKALAFEKYTQWRERFPALSVVMETGDQEAMRTVDAIMDEVFQTDIIITTPERWDGITRRWKEGVVWNLVASVALLMLDEVHTVSEERGAALEAVVSRMKAIKLSMTTRGPQVCRTRFVAISGTLPNIEDFAEWLQVPPAGVFSFTSADRPLPLTLRVVSYPSTSSNPFAFDRFLTLKLFGLIRRYSEGRPTLVFCASRGETMNSARRITEELNEAAAREGCERQLCASEEVQRLASSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTTFFKNGNRDDLPLSEIAQMSGRAGRPGLDTHGVALVLTTDDKAYLYKPLQHGDTCTTVESRLHQNMIEHVNAEVALRTIHNLSLGVEWIKTTFFWIRLRRCPRRYGIIFSTKQEEDDFDREQFADQLMRRMLAELEKQGCVAIGRDALKAGDVILNESATQTLQDRSPSSTGCRDVSDVNCAVESTRVGRAMARRYILFKTVETLNRELLHRFSHQSGRQGAPQIMGAAMAEEEGQIQQKTGESFTLHQVLRVFCHSSEFDGLRLRQGDKKHLNELNKVIRFPLNCGMRGGREVREDWHKVYVLIQAHLDRVAVSDFSLRNDCVRLWTVAPRVARFVVDYATTHPCFSLIQQSSLLCRCIEQGTWWDGLIIKQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNPPFGTDLQEKCHSRPMYNLALEHVTEAGTVRVVVSYKAGVSTRRDPPLEQCHMILLVGDLELDRTHLLRQIDCRTANRRPLVFTFQVSPGYRGQIMGSLTNGNFLGNDCNATLKVGGVEAGDSVKLQTATGFAQQPKHRTTAEKMQGTLKKTPDDVKVTDRNADRDSINEPVPHNRRSTEPFVTTPHQVRGDTSVIADQCASDLEGGEIGTTSAERGAHSAAVGCDDEATVVKTKMADSESSRRRDTEAGQTDEAFKYLLERKAQIASSMGIRVVSSPFGYKRRRENKENGSGDSPETRWSPQISCKEGDDMLLGGMEVVLPKTLSPPPNPVTDVGRGGARPSKRFRFNVQGVSPYTTVGRHAHYQGCYGDTRAAATHPIVNTIESGVSPLFPHTTPPATYSTGHPTFQRSIFECPHASTPPHRTGVVHQLRVTTNAATSGRQLSHVGVDAYRQSTFSKAECFAPFTWGPRCVANASGAFAHGSAPQLPLGGSVACFGEVPRAEPSPLRRARPTEFGGYTSHNGVVDPSIRRGVVRHTTVHRGWW
Protein: Large ribosomal subunit protein eL28 (60S ribosomal protein L28) (A0A286YBP4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Large ribosomal subunit protein eL42
- Ribosomal protein L26
- Small ribosomal subunit protein eS25
- 60S ribosomal protein L7a
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein uS12
Sequence:
MDLFYYYWFRTVIMASPHLQWMVIRNSSSFLIKRNKQTYSTEPNNLKARNAFRFNGLIHRKTIGIEPAADGKGVVVVLKKRSGQRKPASSYGKITINKNSRATLASVRNIIRKNKYRRDLRMAALRRVSAILSSQKPVVVRKKRSRAPKSS
Protein: ABC transporter B family member 1 (ABC transporter ABCB.1) (Q54BU4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MTKKNFNDEENESLLETYNKQQQKQSISTTNRSDQKFGINNANKQFSLNNKKSINGEEIDEEELIEDTIFFKFKLDSKQRNSIKLFIQIVSLVILAGYLISINALYFSTNARSIIFYPSINSNTTDSGSVSPTSTPSPTPTPTPSPTSLLLQTLTSTTTSYDSSEIEALNGGTFNMKYFFYFSTFDILLISYFISLFWLLLIFSDSFIYHTISYIITIIALIYNVIKSYFTITQILSINNNIITTSSSSNEIYNGSDSYLPNESPLFDSLKVREIIIVIVLVGIPLMVLFLVLHIITLQLSFKKYKRLSDKEKQFYNQSNEEKRLNKKVEVKHSNLKRLIQLSRPELPIILAAMVALVFSSLTSLAMPYFFGSIVQVVATTHSFNNLNSSTLALVVIFVIGSISTLVRSWLFYLAGQKFVARIRRNLFSSIVNQEIGYFDQCRTGELLSRLSSDSQVIQNSVTVNISMLFRYTIQIIGSVILLFITNWRLTLLMLGIVPVLAISTVVYGKKIKQLGKQFQDELAKSSTTGEEVISNIRTVRSFSKEQKFIDLYSKDINGSYLIGKSLAVATGVFSGIVFLVAQLAIVLIVYVGARQVLDGTLSTGDLTSFLLYTLSLAMSLAFISSLMTDFLKAIGSSDRIFEIFDRVPAINVSGGKQIQNPLGEIELKDVEFSYPTRPNNSVLKGLNLKLSKGTITALVGPSGGGKSTVIAMIERFYDPNSGSITFDGIDIKELDPVWYRGIIGYVSQEPVLFAGSIKDNITFGNDSATMDQIISAAEKANAHSFIEEFENGYDTIVGERGVRLSGGQKQRVAIARAMIQNPMILLLDEATSALDAESEYLVKQAIDEIMKDRTVIVIAHRLSTVINANTVVVINQGKIEEMGTHKELLNNTDGIYHNLVKRQLSSDD
Protein: FAD-linked sulfhydryl oxidase erv2 (EC 1.8.3.2) (Q9Y806)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mitochondrial intermembrane space import and assembly protein 40
- 2-hydroxyacyl-CoA lyase
Sequence:
MILNRRIQVILPTLLILSFIIWIFHSVMVDKDWRLFMPEIKSLPDREGQGRKPIEMMSTKHDNNTNNLMVNAYWKLIHTVVSNYPNRPTLDERDILRHYLFSSAITMPCGEYSVELQKILDVHPPQTSSRKAATTWACKVHNQLNEKMNQPKTSCDGFNERYVIGSPTYRESEAENVPERVQVINEDHDYSG
Protein: Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (Potassium channel, inwardly rectifying subfamily J member 2) (E7FGH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane, sarcolemma, T-tubule {ECO:0000256|ARBA:ARBA00024012}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 1
- Potassium voltage-gated channel, subfamily H
- Potassium voltage-gated channel, subfamily H
- Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
- Gap junction alpha-1 protein
- Ryanodine receptor 2b
- A-type voltage-gated potassium channel KCND1
- Voltage-dependent L-type calcium channel subunit alpha
Sequence:
MGSVRANRYSIVSSEEDGMKLATAAVPNGYGNGKSKVHTRHQTQSRFVKKDGHCNVQFINVSEKSQRYLADIFTTCVDIRWRWMFVIFCLAFLLSWLFFGCIFWLVAIFHGDLENNGHKCVSNVSSFTAAFLFSIETQTTIGYGYRYVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNATVAMRDNKLCLMWRVGNLRKSHLVEAHVRAQLLRSRTTAEGEFIPLDQMDIDVGFDSGIDRIFLVSPITIVHEIDEDSPFYDMSKQEMENSDFEIVVILEGMVEATAMTTQCRSSYVANEILWAHRFEPVLFEEKNYYKVDYSRFHKTYEVPSTPLCSARDLAEKKYIISNSNSFCYENEVALSNKEEKEEGHGDSLGPGGTNTETSSDSEHSQATVPLEPRPLRRESEI
Protein: Pectinesterase inhibitor 9 (Pectin methylesterase inhibitor 9) (AtPMEI9) (Q9SI72)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pectin methylesterase (PME) inhibitor that probably targets root-expressed PME, regulates de-methylesterification of pectins in roots and affects root growth.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:Q9STY5}.
Interaction partners:
- Pectinesterase inhibitor 5
- Pectinesterase inhibitor 2
- Cell wall / vacuolar inhibitor of fructosidase 1
- Pectinesterase inhibitor 1
Sequence:
MELKNTIFLVILLSITILQSSSATPNRSESDQFIVSSCQTTQYPSLCVHTLSAYATKIRHNNDQDLAQTALIISLARAKSVTIFVAKLTKETPKFKRREYLAIKDCIEVLGNSVDRLAQSVKELARAGHAVASEDFMWKMSNVQTWVSAALTDETTCLDGFSERAMGGKVKRLIRYKVVHVAQVTSNALALVNQFAEKRSVKFP
Protein: DNA topoisomerase (ATP-hydrolyzing) (EC 5.6.2.2) (Q8I0X3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- DNA topoisomerase 1
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Structural maintenance of chromosomes protein 2
- BTB/POZ domain-containing protein, putative
- Structural maintenance of chromosomes protein 6, putative
- NADH-cytochrome b5 reductase, putative
Sequence:
MSFKFSIVFVLYLLFLLKFNKRFIFLKSEKITSYINTQIPNYSSSPPFFLKKEAKNNIKKCYFIKREGYRNIGTKNASNAFVLNFKSNRSTYTDNAFSCTSLCSEKKERKKVQDPYDLKAKKKEKTYELNDIKNNEKKKDDIVNASNDITNDKLDNINNNINESRKLIKGEYYDVEICEILSKSFLSYANFLILNRCLCDYRDGLKTVQRRIIWSMYEINKGIDKKGYKKCARIVGEVIGKYHPHGDKSVYDALVRLAQKHHNNNLLIKGYGNFGSVEYNAAAMRYTEAKISSFCYDILLDEINDENVEYIKNFDGNEREPKVLCSKIPLLLINGCSGIAVSILSSIPCHNLIDVANCCINFLINENIRDDELFHIIKGPDFSTGGIIISKYDILKNIYNSGKGNFEIRSNVFFEYIKNDKKVITKHINDLSSIENSDIDKLTKKIIIKNLPPNVKPNELIENIINLLNDKKNEHDNILLRIRDESEKEDMRIVLELKKHSQIEQIHNFLSYLFKYTNMQISYHCNFVCIGYENTYTQFSLKSFIKLWCNNRIKFIKTNYEIKNKNLQKQLNIIDLYLIIQNKILDIITFFQKNQNIEQIQLYLKNNFKLNPEQIKYILSIKLQKLINIKNIDFISQRNKIMHQIKLNDEIINNVQNIKNLIIQELIYIKNKYGIHNLNKQCIIPSTPKYKYSYINSEYHPNFSKNKQIIDTYNTVSTNDNNINHSNYTHDLPNTDNVTKDKNVVETNVHKNIHISSDISNNIKNSDKNSSLTKNQDSDNMMPYRNTYIDSLDNNMKDIYNNDEVLILITYGGYIKKIKINEKLKNHSNNIIKLSNVKYILKENEEKLNENNKRLKFNDLQKGNEQEKYKDNEQKLNNDIGHNINIQNNNNDNNNNNNDNNNVLLLNEEEYNSYKIKKSILVRNRDKILLTDNYNKAFLLNVYDLHLSSYDSKGTPINQIIHSSKNITGITKFQENKKYLIVCSENGKMKVINNDVFLKRKKKGIKLFKNKKNIYFSYCNFNDNCIVGTKNGYIIQFPLSSFKISKKNSLGNKCISLAKNDKVVDLLSYENNEKNLKNYKIIFVTKNGFGKMINLNELKIQKKKGKGHRIMKFKKSKTRKDNKKDIEKKQINAINNKDKDKDIPSNNDDNNILHNTKVDEFLGFKLYDMNKQNEKDILIMITDHAVLIRKNMSLLKEKNKKHSSQIYAKMNKINQLVYFDII
Protein: Cell wall alpha-1,3-glucan synthase ags1 (EC 2.4.1.183) (Cell wall alpha-1,4-glucan synthase) (Q9USK8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for alpha-1,3-glucan and alpha-1,4-glucan production which are required for cell wall synthesis.
Interaction partners:
- 1,3-beta-glucan synthase component bgs1
- 1,3-beta-glucan synthase component bgs4
- GTP-binding protein rho2
- GTP-binding protein rho1
- Protein kinase C-like 2
- 1,3-beta-glucan synthase component bgs3
- Uncharacterized protein P22H7.03
- Cell division control protein 15
Sequence:
MHGLQGLCFRRAVIALALLLFHSVFAAPYSEDEEPWNLNQNKNASSVLEYSGEWADHDFFPSPDNWRMSFITVILDRWYDGDPSNNDIEKTPFEYDISEVSFRNGGDIVGLELSLDYLEGLGTQGIYIAGTPFVNMPWGADQYSPLDYTILDHHLGTIDQWRSTITAMHERGMYLVVDLTVATLGDLIGMVGHLNDTSGVDFNLNEYNAMWKTSEYRYVDFNFTNVYNTSCEYPRFWGEDGGPVSIQFKGCYVSDYDHYGDTEAFGSHPDWQRQLSKFASVQDRLRDWKPDVAEKLMHLSCLVISMLDVDGFRIDKATQMTADFIVDWSMYVRECAAKYNKKNFLIVGEVTGSSSYGSIYYNRGRQPDQRPPNVTAAFNYTSDESQYSLRDSDHYGFDGSAFHYSIYRALLRFLGMDSKMEIDFDVSSVLTTAWNGIQINEDAVNINTGTVEPLHMYGVANHDVFRWGAIENGTARLILGTMITSLLFPGIPLLYYGDEQGMYVLDNSANNYLYGRQAMNSARAWYIHGCYNGSATSYPTVDLSPAQRGCQDSWNYLDHFDIASAHRNVYRNIHSIRRHYLSLSEGWRFDHIANWTDDVYFPDSQPYASPMGLYSVLRGPMKEIQDFDSITNASNVSKSEVWVLYANRNDTHLWSYDCTDEDSAIIGPWKSGTTLRNLIYPYDTIELEDSWNSSWGCIPNIELDPYAFKLYVPEEDFIENDPIITSLTPEHDARVVASGNEIDLTIEFSRSMDCDSIKNALSVVSSTRPKNTTAVIDVDSSFCRNYSEDASTSLHGQTAGRFAWYGTLTNIDPGIHRISLKSVPTSDFSSRTLSTDNFLIRVGSTNNPIVHYSANYSDTLLIMQDGDLYINHSAPGAVLFRYSTDFQSHWSDWEEYNGGLTKVQASNWTGTRRQGWEGHHIHVQYWSDLGGSANHMQQSDYGFKYRRFLPHMFLEGDFNEYGYDSGVENRFLQKSDFYWEAGFISETYPAAIQLNVWGMNPDGIPDKTRVYGSQGNSTVLSRSDPASLVGNNITIYHPPPHGYLSYKILLRDDDMIYRLAPSGEWGVSIAIYVLCIVIPPLSAIVVSWAFKNSFYTVKFNKHGNNDLGKFYPLKSLVPFRKKNDLDSPAKVTPVVSGVSARKKKCVLIATLEYDITDWKIRIKIGGLGVMAQLMAQHLKHEDLVWVVPCVGDVVYPEAEEASPIEVKIIDQTYTINVYHHYLDNIKYVLLDAPVFRRQTSKEPYPARMDDLGSAIFYSAWNQCIAEVIRRNPIDIYHINDYHGALAPCYLLPDIIPCALSLHNAEFQGLWPLRTPEEKEEVCAVYNISQRVCTKYVQFGNVFNLLHAAVSYIRIHQKGFGAVGVSNKYGKRSWARYPIFWGLKKIGKLPNPDPTDTDEIVDDKAVAITDIDPDMEKSKVEHKRLAQEWAGLEVNEKYDLLVFVGRWSSQKGIDLIADIAPSLLESYKVQLICVGPIIDLYGKFAAEKLDVLQKKYPTRVFSQPKFTQLPPYIFSGADFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYSVESSATPHLLKQFEQACQQALSSSQRTRARLRARSAKQRFPVSQWKAKLEALTDGCIKCSQKYGRNSRSRSSFYSLIHESFSRSSEVLPTSSDTNLDAKRAEEAEMIMIETPPTAEANTGAKLDRSLSLGSRRGPGHTTEDDASDGLDTIQEESMTAGDSTSGGSDISRYRAERLNPDSHSPSEYSFDSGDYEFDPQRSYYYDDLFDDDTTIRNAPSFRPQMGSFDAEHAVGATFSQDDLSDPARSVDSDSVSPPLPPFVAGSNPNARNNNNPYFYGNLHTESSLSLASVMSGKEKRDFSLTRVEETFTDEDGQALRSFSEKLQKLNAKNSKDDLCIEQYLMKSERSFFHERRAIKLGLQKPNKLHVNELSSHSGTEESESLSNGQTSYDDIIAMTDESNYTQLGDDDFKTIHGLKKFMLFKIYDWPIYSIFLALGQILAATAYQLTLFTGTSNIQTYEIYSVCAFFIGASFVWWFMFARLPSYYVLSIPWLFYAVALFLVGLPAFDTVAPGRVWITNVAAWIYAIASASGSIFFSLNFGEEGAVQTRIWVFRACLVQGVQQVWSAALWYWGAHLNKRLTAGEANTFKMSPAIPSITWPLSAVSILIFALLFKGLPEYYRQLSGSIPAFYKSLLRRKLVVWFCISVFLQNFWLSSLNGRSWSYLWDIGNIHQWQIFLLIVAFYIVLWALLLGVLAWISRTHSWIICVFGVGLGAPRWLQQFWATSNIGLYLPWAGYSGPYLGRTLWLWLGVLDAIQSVGIGMILLQTLTRRHVASTLMTGQIVGAVATMIGRGASPNREGPANVFIDFTKWNHGDGSSILASAPFWINIICQLAICVGYLAFFRRENLSRP
Protein: CID domain-containing protein (Q38AI9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNKEKVDRRLDLVGSSAGSIISVATWCALHASSVDVIMGAINERMQDPATSASTRCALLYVVHELLLTCAANGVPEAGKRRVLTAVSRVIPEAVTAVRALSPADSDEFERGLSKVASWWSLLNIFPRVWIDQLGARNDEVPSSESVAGASMSAQLRYIAGLMSRYNEAKEEWLRALQTSPERAATLRGEAQQWLASVRAAVENKLEGGGSLATWLSAELSVLTGSAPNPGGSFVGKEEEDDVLGSFFQKGK