wanglab/gogpt-training-data huggingface dataset:
Protein: Acetylcholinesterase (AChE) (EC 3.1.1.7) (Q9DDE3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Subcellular location: Synapse. Secreted. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Glycerophosphocholine phosphodiesterase 1
- Muscle, skeletal receptor tyrosine-protein kinase isoform 3 precursor
- Ethanolamine kinase
- Ethanolamine kinase
- Probable phosphatase phospho1
- Probable glutathione peroxidase 8
- Glutathione peroxidase
- Glutathione peroxidase
- Glutathione peroxidase
- Glutathione peroxidase
Sequence:
MKTSDILLLPTVLLTFLFHNCFAQAEPDLVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEPKKPWNNVFEAKEFSNACYQFVDTSYPGFPGIEMWNPNRVMSEDCLYLNVWVPPTPRPQNLTVMVWIYGGGFYSGSSSLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSSDAPGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRRTTKLGKLVGCTWGNDTELIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVPVVDGVFFPDTPDAMISSGNFKYTQILLGVNQDEGSYFLLYGAPGFSKDNESLISREDFLESVKMGVPHANDIGLEAVILQYTDWMDENNGQKNRDAMDDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLFDHRASNLAWPEWMGVIHGYEIEFVFGLPLEKRLNYTAEEEKLSRRIMRYWANFARTGNPNVNTDGTMDSRRRWPQFSANEQKHVGLNTEPMKVHKGLRTQFCALWNRFLPRLLNITDNIDDVERQWKVEFHRWSSYMMHWKSQFDHYSKQERCTDL
Protein: OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) (Q6GQQ9)
Organism: Homo sapiens (Human)
Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. {ECO:0000269|PubMed:21888622}.
Interaction partners:
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eS31 fusion protein
- WD repeat domain phosphoinositide-interacting protein 1
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eL40 fusion protein
- Parkinson disease protein 7
- TNF receptor-associated factor 6
- WD repeat domain phosphoinositide-interacting protein 2
- WD repeat domain phosphoinositide-interacting protein 3
- WD repeat domain phosphoinositide-interacting protein 4
Sequence:
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLVHRF
Protein: NEDD8-activating enzyme E1 regulatory subunit (Q586W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin, putative
- Ubiquitin-conjugating enzyme E2, putative
- Uncharacterized protein
- Uncharacterized protein
- Cullin 1, putative
- DNA damage-binding protein 1
Sequence:
MSNEKYDRQLRLWGHAGQMALAESHVVVLGATATAVEMLKNMILPGLGFFTLVDGSFVDADTLGNNYFVELSDYAARKPLSEVLVKRLCELNPHSSGTACVQSCVEWSDSFISSTSGGRDFVGRFPTLIVATPRLPATHLRRLADHLKSASLRSIPLMYVQTCGLSGIIQIQDRERLVVHAEPKQEMRVADLRLFNPFPELRSWLDAHDPRDEVLYRTDPAGYGHLPWIAMIYHALQCLRCDKENAEFIPCSKADYDTLRTAVSSLPYLSDRPPDGVHEAMENCRMILNRPMCLSESLEQLLRDPRANGHFIDWSGGFPVSGVPPITWAVLYGINRFIAENNGVPPFCGFVPDINTTTQWYRELRSIYNNKMEDDCCVVQGYAMEAINASNVMGGKFTSDTAASTALLVGEKTGLETEVSALTRSLVQNIWTLQLTTFSPSLDIDSHELLQRESFERYLSDCVDASEQFTVMLYAALLGARCFEEMFGRWPGLLDSLNGRVHYGDKDDTLLWMSDGEELIRIVGERILNESGRSDKVVDECLMRKACMEVARCGCGEPFPTAGVMGAAAAQECIKLLQHRRVPIQRPLVFDGYRSCFWVAEAQ
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q57X36)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MHHWIALILLLCGTANRTKVKAANDKALTKNGLEQVCDIAAEVRAKEQVHADGLTAAADKLSANQAVLAKVRILIAAASTAQEALQLQAISAALHRTAAEEAAKFTKATAMLAIEAIRRSNYLLRGLYEYLNIAGQATNANTNGCFADDENAGTLYTSDQLAAQVANCKATDLGHTTGWQDKSAHRPGGYKRKTDKNNLWSTNAKGCKIHGGGNNNGPVESATYGANKHVAMGLISLSSTDAQLTDLSSLAGPEGDSKKRHAEKSFNKLSQPALVINTIELPDKNALKNLANFDATLAAAVGASKPFSGQEKEQAMEKLYGSKDPDPTTMFWNKLKTMTLAEDSHGVTKGTKLAEISNLPLLTELETNYTINKAIQRNIPTAADACNCSSAQPTPEEKLCNEATGDEGKCETLKEKGCIFDRNTKKCELKKDVKAQLEKANQETEGNDDKNTNTTESNSFVIHKVPLLPAFLTSNEKYLEFFSIL
Protein: NIF3-like protein 1 (Protein anon-35F/36A) (Q9NK57)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GPN-loop GTPase
- Ribonuclease H1
Sequence:
MLRRMNTFSGQKLAAVVKELENFAPTSWAEKWDNVGLLIEPHREKQIKKILLTNDLTEPVVKEALEKEAELIISYHPPIFKPLTRITQSHWKERVVAACLANDIALYSPHTAWDKKSGGVNDWLSKAVNIISIRPLEPELGAPPGTGSGRYIETKMELSQVVESLQKRIRNSVHVALAVGHTPKTLIQSVGICAGSGASLLKGIQADLIITGEMSHHEVLEFTHNNTTVLLCNHSNSERGFLHEFCPILAKSLNEECLVFVSEVDKDPLVTVASDINKELSAFVDVYKSTSK
Protein: Inositolphosphorylceramide synthase (J9VSD3)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSAIRALTSPVTACFSTSLSPHAAFHRFLHALSASIRRLDLSRDPRKTLDRLRQHRFTLANTLPRAFMLLCASYSLYIMTTPPFPLKLGIPIAYIAAVIFPITSQFVWPATPIFAWLITFFSARFIPSGRRPEIHVALLPALESVLYGANISDLQTRYTNAFLDVVAWLPYGVLHFTLPFVVAVILWSLGPRGAVQFWGLAFGWMNLLGVVCQLLFPAAAPWYEIIHGLTPADYSMAGSPGGLMRIDRVFHSSGYTNAFGSAPLVFGAFPSLHSGCAVMEALFLSHFFPSLKGLYWGYVGVLWWATMYLSHHYLIDLVGGACLSVLVFYLCMPEGFKDVDQIQWEAVEGDGYEMIGGPRTGTGPEIDLDEEIRKLEEQGEALFEQVIGDEESRIETRGEGNSGAGGNLSGNESGDSADSGRGKGKGKGKGKQTAKKPKAKEQRSVSWGETKVMGEGAQVASENSS
Protein: Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (O60361)
Organism: Homo sapiens (Human)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
Interaction partners:
Sequence:
MQCGLVGKIIKRFEQKGFRLVAMKFLPASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLRFKPEELVDYKSCAHDWVYE
Protein: RING finger protein 151 (Q9CQ29)
Organism: Mus musculus (Mouse)
Function: May be involved in acrosome formation of spermatids.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17577571}. Nucleus {ECO:0000269|PubMed:17577571}.
Interaction partners:
Sequence:
MSGGYDLNLFASPPDCKFLCSVCHGVLKRPTRLPCSHIFCKKCIFRWLARQNTCPCCRKEVTRRKMVEVNKLRKTIGRLQVKCKNAAAGCLDTHPLAHRKEHQDSCPFELMACPNEGCTVQVLRGVLDEHRQHCQQNGQQRCPLGCGSTLAALEGEHHNCYRELRDAWVQRHERNRTLLLGLLGRVRRVHLTTSIIHQQLAQLSNFLEDDDNLLLNAQVQETEVTPEAEMRGTQGQSVL
Protein: Sodium/potassium/calcium exchanger Nckx30C (Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C) (Q9U6A0)
Organism: Drosophila melanogaster (Fruit fly)
Function: May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein, isoform B
- Golgi to ER traffic protein 4 homolog
Sequence:
MLQPTTCSKQQQQRQQPAIATAAVGGAAVQELLRKAAAKDHGALAAATATATAASTTATTATAATASRNSSNTWCHSDDMLSAGRSRSSSTTIDFNSRRRRGRLRGHAPSDLAMNKQHQATILDECVNIFKRLVLLTLKTISATTITKAKTRSRTAAQLPATSAASATSSRGASAEQLLHPSSRSRCRSRRCLRLPIYSILLLCLTTQGLGLGDAAKPRPAKQHFGGSNSNSPNQNQNHNDVLGGVGAPSQTSGEDEAEIMYPFQSGEQMFGLEEDQEQDPELNSNAVPGSDEDNAGNQRGINDTHNDNSTTTKTPLFPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRVRSTDQLMPAGNAANSSETSMATQPGGSVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTGAKFRHGLLQLMIHTIDPLHDGKVDEKATQLHAIASLKVLLDATKPQRGGATTSAANHVKINLKETTLADRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGIIYGAPVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTMFLLYFAFVAVSLMFEYDVITCPF
Protein: choloylglycine hydrolase (EC 3.5.1.24) (Bile salt hydrolase) (Choloylglycine hydrolase) (B8DUI5)
Organism: Bifidobacterium animalis subsp. lactis (strain AD011)
Interaction partners:
Sequence:
MCTAVRFDDGQNNMYFGRNLDWSEDYGEKIVFAPHDYHYAPAFNAEDKNHPVIGIGIIVEDTPLYFDCMNDAGLAVAGLNFAKYCKYATEAVNFTTNVAAYEFPLWVTRNFTSVDDVQEALKNVTIVGKPINDRFPVATLHWIIADNTRSIVVECTEDGMHVYDDDVDVLTNQPPFPQQIEHLDNYAYVSPRTGKSVKWGSSELETNQDSNSSQGLPGGYGSMARFVRAAYNNTHYPTQSGENANVNRLFKTLSTAAVIEGTAISANGEFEKTLFSDCYSTATQTVYLKKYDDMAVHSYAVKDFDASSNQLQSK
Protein: Amino acid transporter AVT6D (AtAvt6D) (Q0WQJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- SNF1-related protein kinase regulatory subunit beta-2
- At5g06430
- WAT1-related protein At4g28040
- ACT domain-containing protein ACR9
- SNF1-related protein kinase regulatory subunit beta-1
- At1g10140
- Polyketide cyclase / dehydrase and lipid transport protein
- Nucleobase-ascorbate transporter 8
- Formin-like protein
- Chaperone protein dnaJ 8, chloroplastic
Sequence:
MSPAIKAPLLPNQEPSSSSSENHGSFAGAVFNISTSIVGAGIMAIPAAFKVLGVIPSLSIIVIIAWLSNVSAGFLMKSSLAGESTTYAGVMKESFGKSGAVAVTVVTMVVTFGSMIIFSIIIGDVISGNEKDGIIHLGLLQEWFGSHWWNTRFFGLLFIFVFLFLPLVLCRRVERLAFSSAISFLLALLFVVISSVLAIIALVQGKTKPPRLFPELNDGGLSFFSLFTASPVIVTAFTFHFNVHPVAFELKDPLNVLSATRISVILCATIYSATGLFCYLLFGDSTMTDVLMNFDQSTSSSVGSLLNDIVRLSYAIHLMLVFPLLNFSLRANLDELLFPMKLSLVEDNKRFFALTFPLLISCFLGAIAIPDIWYFFQFLGSTSTVSIAFIFPAAIVLRNVNGFSTLREKIVASVMLVLAVATSIIAISTNIYTFTATEET
Protein: Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) (Q9CQ49)
Organism: Mus musculus (Mouse)
Function: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P52298}. Cytoplasm {ECO:0000250|UniProtKB:P52298}.
Interaction partners:
- Nuclear cap-binding protein subunit 1
- Serrate RNA effector molecule homolog
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein F
- Phosphorylated adapter RNA export protein
- U1 small nuclear ribonucleoprotein C
- RNA-binding protein 25
- Small nuclear ribonucleoprotein Sm D2
- Splicing factor 3A subunit 3
Sequence:
MSGGLLKALRSDSYVELSEYRDQHFRGDNEEQEKLLKKSCTLYVGNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKKTACGFCFVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGFKEGRQYGRGRSGGQVRDEYREDYDAGRGGYGKLAQKQ
Protein: Villin-1 (B4DV78)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, filopodium tip {ECO:0000256|ARBA:ARBA00004495}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYEDLKAELGNSRDWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEKGLF
Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Q9YHZ7)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Subcellular location: Nucleus.
Interaction partners:
- Progesterone receptor
- Transcription factor Sp1
- Aromatase
- histone acetyltransferase
- histone acetyltransferase
- Mediator of RNA polymerase II transcription subunit 1
- Nuclear receptor corepressor 1 isoform X9
- aromatase
- G-protein coupled estrogen receptor 1
- Nuclear receptor corepressor 2
Sequence:
MSEEQARAEAPAGARQRRRSELEGYSVSLASLKLSPMYPEEEQRTTGGISSTAHYLDGTFNYTTNPDATNSSVDYYSVAPEPQEENLQPLPNGSSSPPVFVPSSPQLSPFLGHPPAGQHTAQQVPYYLEPSGTSIYRSSVLASAGSRVELCSAPGRQDVYTAVGASGPSGASGPSGAIGLVKEIRYCSVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQACRLRKCYEVGMMKGGFRKERGGRIIKHNRRPSGLKERERGYSKAQSGSDVREALPQDGQSSSGIGGGVADVVCMSPEQVLLLLLRAEPPTLCSRQKHSRPYSELTIMSLLTNMADRELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEILMIGLIWRSIYTPGKLIFAQDLILDKSEGECVEGMAEIFDMLLATVARFRTLKLKSEEFVCLKAIILLNSGAFSFCSSPVEPLRDGFMVQCMMDNITDALIYYISQSGISVQLQSRRQAQLLLLLSHIRHMSYKGMEHLYSMKCKNKVPLYDLLLEMLDAHRLRPLGKVPRIWADRVSSSPTTTATTPTTNTTTTTTTTTHHPSNGSTCPADLPSNPPGPGQSPSP
Protein: Protein shank (B7WN72)
Organism: Caenorhabditis elegans
Function: Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions. Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density. The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4. Plays a role in the regulation of the defecation cycle, and this may be in association with the inositol trisphosphate (IP3) receptor itr-1, which in turn mediates periodic calcium release and muscle contractions. Required for normal fertility and pharyngeal pumping.
Subcellular location: Cell projection, pseudopodium {ECO:0000269|PubMed:15013747}. Cytoplasmic vesicle {ECO:0000269|PubMed:15013747}. Postsynaptic density {ECO:0000305|PubMed:28477407}. Note=Localizes to sperm pseudopodium. {ECO:0000269|PubMed:15013747}.
Interaction partners:
- Protein kinase domain-containing protein
- GTP binding protein
- GTP binding protein
- GTP-binding protein Rheb
- GTP-binding protein drn-1
- SH3 domain-containing protein
- RING-type domain-containing protein
- GTP-binding protein
- small monomeric GTPase
- RAP homolog
Sequence:
MNQEEDTVNLQIFVPELNVRKFLAVTQNDFIWDVKRKLLATLPQALPQAFNYGLFLPPCDGRAGKFLLEDRTIRDYPFTDCVPYLELKYKKRVYKMLNLDEKQLKAMHTKGQLKKFMDYVQQKNNEKVEKMCSQGLDANFHDAQGETPLTLAAGIPNNRAVIVSLIGGGAHVDFRNSEGQTAMHKAAFLSSFENVKTLIELGASPNYRDPIGLTPLYYNMLTADSNDQVAEILLREAADIGVTDMHGNHEIHQACKNGLTKHVEHLLYFGGQIDAENVNGNSPLHVCAVNNRPECARVLLFRGADHLAVNKQGQTALHVSHIVGNPGVADVVQAHNPKSSVPYRGTPQYSTRRRLSSTITRRRSMSQSSICSQDVYRTPQSVRKGPMSAAPSPSPSRSSRTTITPSEYGTMRRSGMDSMRGGGMIAAGHETNIARILVIPRGVKGFGFILRGAKHVAMPLNFEPTAQVPALQFFEGVDMSGMAVRAGLRPGDYLLEIDGIDVRRCSHDEVVEFIQQAGDTITLKVITVDVADMSRGGTIVHRPPTASSRHSLVFTPTPSAIYSSTKASSVYRMRFDTHDAHGVDYYAPNEIRNAYSESRHASVRQRPGSGRRISAAELENLMVRQRVPSVQGSPYQMQYDQESLNGGYSSKKYNSVSDMKRRKGQRNVVASSAGLNRSTFEQAAPTTSTFEYNCSSRSTPQLSRMDSFDSFDDEDEMPAPPPASYISPDLQRDSSMQRSEYSRPFRPTSRPKTPPPPPPMQHQNHQNHQYQQQHPSLPRSASTPQPIQQQQSSIPPPPPPPPPPHCEPTMVHVEFTPPSTSSVPPPPPPLPPISSGAPPPPPPPPPGGLMHVAASAPVLMSNSKGISADALKSVQLKKAEPRETSAASVSNNNNNNNNSTTDFQMDLKNALAKRRSKVAHDVDEDEERESRFEGLSLRETVRENVVERGKGIQNIGIVNKKDSGYTSSRTSLEPSESEEKDHRPHFSLDHSPNVQRVTLISQHLEDNYGQKDNMSVASSSTASSSSTVDLTKPGCFVVPSHVIPPVDYDDDPDSGTGDSDGEIRCSEISFEHKKVDVWSVDDVIGWLSSLHLSEYTPAFRSQRINGRCLRQCDRSRFTQLGVTRIAHRQIIESALRGLLQ
Protein: Bromo domain-containing protein (Q38AE9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- histone acetyltransferase
- Histone acetyltransferase
- histone acetyltransferase
Sequence:
MSDTTRRVKLLWTRVRRKYLEVHHYLDTSFYKQCRSILHVVMDLDRDGIFARDPSKLPDYRMIISHPMWWDLIKARLTRYEYTSPSAFINDMRLVVQNCYDYNREESPFSTLARRIEIAMEDLFVTELSLDPPDPREVLRLGGSASKSHGRQLWEIICRYEGCKRGETPKHQQIRPAELKCATRRRLIMELRRLSAKARGGTHGGRSEKAASAQRAQPPASSSRRPEKAKFPTRSILETDDDVHFREEQNVPQEPPRKEPRLERVPQNERAGFSSFALLSPVEFDEGSDEVQFNEEARVEN
Protein: Protein chibby homolog 2 (Protein nurit) (Spermatid-associated protein) (Q32MG2)
Organism: Mus musculus (Mouse)
Interaction partners:
- Spermatid maturation protein 1
Sequence:
MSPLECSECFGDQLLHKTYTWHLTLHSRPNFTRKRDTRSESLEIPVNVILPQRGTEPFLRLHNLYSTPRCSRQAALPRMSRRVASQHSYPLNRFSSMPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNESCRLQPPYFSPPSSFHHKLHHRRLAKEYQLQEENKSLRDENRALRDENKALRKENKILQVFWEEHKVTLGHEESQTSSLLHKDTTSQEVVKRDNTTLPAQRSKESTLQLIREENRALQQLLEQRQAYWAQAEENAASTEEGKSTSSPKEESHNSGLLPDQSTNHSSPFEDPKVPPTTQEDSKTLRALREMVNNLSGASGEEDGKVGPNLPDSAQPLQLLREMNQALQALQEENRLLQEENRALHILREEHRVFQEENKALWENNKLKLQQRLVIDTVTEVTARMEMLIEELYAFMPAKNNKDPKKPSRV
Protein: Nuclear receptor subfamily 4 group A member 2 (NUR-related factor 1) (Orphan nuclear receptor NURR1) (Q06219)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P43354}. Nucleus {ECO:0000250|UniProtKB:P43354}. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. {ECO:0000250|UniProtKB:P43354}.
Interaction partners:
- Period circadian protein homolog 2
- Pituitary homeobox 3
- LIM homeobox transcription factor 1-alpha
- Protein FosB
- Synaptic vesicular amine transporter
- Tyrosine 3-monooxygenase
- Early growth response protein 1
- REST corepressor 2
- Homeobox protein engrailed-1
- LIM homeobox transcription factor 1-beta
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
Protein: Leukotriene B4 receptor (X1WF65)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Leukotriene A
Sequence:
MATPLTPVFSGPPASAVVPAPPSTPPSLPLSHQIGIAILVIAFVFGFPGNLFVVWSVLCRVRRRSVTCLLILNLAVADALVLLSSPLFIRYLVGGKGWEFGPVVCKTVHYLCCVNMYASIYLICLMSMDRWLAVTKPFLSQRLRTKKRLLSIMLAIWVMAFLMALPMPFYRSVVQYKPGVPIYLCNPYHWQSESHEIFQYLSETLLGFLLPFAFILFCYISVILRLRSAMFQRKGRGNFLILIIIAAFTLFWLPYHLINIIQVIGVMQGSSSFLNVAKVGRPNVTAFAFMSSSVNPVLYVFAGSSHIRQAGLGFMAKLFEGTNSEMGSSRSTRSSRGSNTENSVFTKLSVKLNRKGDGAGAETHDGEEGTLADKTLTPLH
Protein: Golgi-associated RAB2 interactor protein 2 (D3YV92)
Organism: Mus musculus (Mouse)
Function: Seems to play a role in sperm motility.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:29025071}. Note=In mature sperm, localizes in the midpiece of flagella. {ECO:0000269|PubMed:29025071}.
Interaction partners:
- Membrane-spanning 4-domains, subfamily A, member 19
Sequence:
MMKKNRNKKAMNKQEALFIPHYYRLGHLKNILDGGEYAPYVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPIFKTPNMMLLAHLTPEARKEPEPLFKTLLKSSSSGTLVLTRFIPLQFVTLSVHSAKNMRLKVKLINGRSYYLQLCAPVYKQDIIFSQWVDLIPLLNQEKIKNTKVSEVSSLSELTNSTDIAGSMDITDITAFRELRPRHPKTHRYPCNIMESADFSEYTDVTDVTDVTDVTDMLDNGITDVQDIKIVTEVTEVTEVTEVTEVSEVSDVKMATNISGVKIVFENDDIIKTKQEEKEYTLKHRSLQDTKTKSDYQDSPNPVTMSNIALALQDEGCFQTTQTPVKSKEDIYKEICDETSEENMIRLQNIHLKATESRSTRTDSDISDGELKLGRYLHKQCSSREQSFIHSLGSLPRGFVFLHLLL
Protein: Myofilin, isoform I (E1JIK9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFKNHLEMIGRNESPSKKAKFWQSYIRSLKGSEDIRAHEAPRASRPYSSYLDSPSYRSIYDEPATANERVQSSGYRYLPVSRDTYGYSPRAIYDHHYSRTIPANYDAEKAWNDHLKRMQEIERRYPSRYGLYLRDKPLTPNSLVPLEYEPEDKLLAELNKARRSASPFRPARTTRAGSEPYVPPPSYWNREGSVPRGGPSVFDRATSLAPFTRPSFRASSLEPLDELFEL
Protein: GH13729p (No extended memory, isoform B) (No extended memory, isoform E) (No extended memory, isoform G (EC 1.-.-.-, EC 1.16.1.7)) (Q95T77)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRDRHLAKMPRGGTTTSRYEEDPDNAWNCCSWCEYLLIVILSTILLVGVLVLTLFWVMFYRDGFAWSESPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEKERETVNEAGVSSENKLVEHYITSAIGVTLIFIGIIVTFAVRRSNAPASAKVYVTERI