wanglab/gogpt-training-data huggingface dataset:
Protein: Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (P23359)
Organism: Mus musculus (Mouse)
Function: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-1
- Activin receptor type-2A
- Bone morphogenetic protein receptor type-2
- Activin receptor type-2B
- Noggin
- Bone morphogenetic protein receptor type-1A
- Chordin
- Follistatin
- Growth/differentiation factor 7
Sequence:
MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEESGPDGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFQITVYQVLQEHSGRESDLFLLDSRTIWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHLRSIRSTGGKQRSQNRSKTPKNQEALRMASVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPDTVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
Protein: Intron-encoded DNA endonuclease aI5 alpha (DNA endonuclease I-SceIV) [Cleaved into: Truncated non-functional cytochrome oxidase 1; DNA endonuclease aI5 alpha (EC 3.1.-.-) (Intron-encoded endonuclease I-SceIV)] (Q9ZZX1)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-ATCTTCTCTTGATTAGCCCTGATCTACGG-3' after the nucleotide sequence ATTA leaving a four-base overhang and a 3'-OH.
Subcellular location: Mitochondrion {ECO:0000305}. Membrane {ECO:0000255, ECO:0000305}; Multi-pass membrane protein {ECO:0000255, ECO:0000305}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Intron-encoded DNA endonuclease aI5 beta
- Intron-encoded RNA maturase bI4
- Cytochrome b mRNA maturase bI3
- Cytochrome b
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b mRNA maturase bI2
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLMNPFSKDKNKNKNKKLIRNYQKMNNNNMMKTYLNNNNMIMMNMYKGNLYDIYPRSNRNYIQPNNINKELVVYGYNLESCVGMPTYTNIVKHMVGIPNNILYIMTGILLTDGWIDYTSKKDLDKKTIMEINCRFRLKQSMIHSEYLMYVFMLLSHYCMSYPKMKIAKVKGKSYNQLEFYTRSLPCFTILRYMFYNGRVKIVPNNLYDLLNYESLAHMIMCDGSFVKGGGLYLNLQSFTTKELIFIMNILKIKFNLNCTLHKSRNKYTIYMRVESVKRLFPMIYKYILPSMRYKFDIMLWQKKYNMIN
Protein: Galactose-binding lectin l-1 (Galectin) (Ajl-1) (Q801X7)
Organism: Anguilla japonica (Japanese eel)
Function: Involved in host defense at the body surface. Causes agglutination of the Gram-positive bacterium S.difficile. Possesses calcium-independent hemagglutinating activity.
Subcellular location: Secreted {ECO:0000269|PubMed:11959866, ECO:0000269|PubMed:14698218}.
Interaction partners:
Sequence:
MDFVEVKNLIMKSGMELKVNGVFNANPERFSINVGHSTEEIAVHVDVRFSYLSDKRQLIINHKTGDAWQEEQRDARFPFTAGQAFQVSVVFNFDTFDIYLPDGQVAHFTNHLGAQEYKYIFFVGDATVKNISVNVADKPTKR
Protein: E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (Tripartite motif-containing protein 41) (Q5NCC3)
Organism: Mus musculus (Mouse)
Function: E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (By similarity). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (By similarity). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:33640899}. Nucleus {ECO:0000250|UniProtKB:Q8WV44}.
Interaction partners:
Sequence:
MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEEVGEEEEVEAVGAGGGWDTPMREEDYEGDMEEEAEEEEEVFWSSGIGGSNWDNMDYVWEEEEEEEEEELDYYLGDVADLRGEDEDEEEEVLEEDEEEELDPITQLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVNEQGICPRHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAANRLEEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEIQLQPPEIWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALLLSPDRRGVRLAERRQEVPEHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGSGGSSVSSGDASSSRHHHRRRRLHLPQQLLLQREVWCVGTHGKRYQAQSSTEQTLLSPCEKPRRFGVYLDYEAGRLGFYNADTLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
Protein: Inner membrane protein YabI (P30149)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane protein YohD
- Inner membrane protein YghB
- TVP38/TMEM64 family inner membrane protein YdjZ
- Inner membrane protein YqaA
- TVP38/TMEM64 family membrane protein YdjX
Sequence:
MQALLEHFITQSTVYSLMAVVLVAFLESLALVGLILPGTVLMAGLGALIGSGELSFWHAWLAGIIGCLMGDWISFWLGWRFKKPLHRWSFLKKNKALLDKTEHALHQHSMFTILVGRFVGPTRPLVPMVAGMLDLPVAKFITPNIIGCLLWPPFYFLPGILAGAAIDIPAGMQSGEFKWLLLATAVFLWVGGWLCWRLWRSGKATDRLSHYLSRGRLLWLTPLISAIGVVALVVLIRHPLMPVYIDILRKVVGV
Protein: Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.128) (Nitrilase homolog 1) (P47016)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8VDK1}. Mitochondrion {ECO:0000250|UniProtKB:Q8VDK1}.
Interaction partners:
- Putative nitrilase-like protein NIT1
- Bis
- Nitrogen regulatory protein GLN3
Sequence:
MTSKLKRVAVAQLCSSADLTKNLKVVKELISEAIQKKADVVFLPEASDYLSQNPLHSRYLAQKSPKFIRQLQSSITDLVRDNSRNIDVSIGVHLPPSEQDLLEGNDRVRNVLLYIDHEGKILQEYQKLHLFDVDVPNGPILKESKSVQPGKAIPDIIESPLGKLGSAICYDIRFPEFSLKLRSMGAEILCFPSAFTIKTGEAHWELLGRARAVDTQCYVLMPGQVGMHDLSDPEWEKQSHMSALEKSSRRESWGHSMVIDPWGKIIAHADPSTVGPQLILADLDRELLQEIRNKMPLWNQRRDDLFH
Protein: RNA polymerase sigma factor RpoD (Sigma-70) (P55993)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}.
Interaction partners:
- DNA primase
- Bifunctional DNA-directed RNA polymerase subunit beta-beta'
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- Transcription termination/antitermination protein NusA
- Heat shock protein
- Ferric uptake regulation protein
- RNA polymerase sigma-54 factor
- Lipoprotein
- Chaperone protein DnaK
Sequence:
MKKKANEEKAQKRAKTEAKAEATQENKTKENNKAKESKIKESKIKEAKAKEPIPVKKLSFNEALEELFANSLSDCVSYESIIQISAKVPTLAQIKKIKELCQKYQKKLVSSSEYAKKLNAIDKIKKTEEKQKVLDEELEDGYDFLKEKDFLEWSRSDSPVRMYLREMGDIKLLSKDEEIELSKQIRLGEDIILDAICSVPYLIDFIYAYKDALINRERRVKELFRSFDDDDENSVSDSKKDEDNEEDEENEERKKVVSEKDKKRVEKVQESFKALDKAKKEWLKALEAPIDEREDELVRSLTLAYKRQTLKDRLYDLEPTSKLINELVKTMETTLKSGDGFEKELKRLEYKLPLFNDTLIANHKKILANITNMTKEDIIAQVPEATMVSVYMDLKKLFLTKEASEEGFDLAPNKLKEILEQIKRGKLISDRAKNKMAKSNLRLVVSIAKRFTSRGLPFLDLIQEGNIGLMKAVDKFEHEKGFKFSTYATWWIKQAISRAIADQARTIRIPIHMIDTINRINKVMRKHIQENGKEPDLEVVAEEVGLSLDKVKNVIKVTKEPISLETPVGNDDDGKFGDFVEDKNIVSSIDHIMREDLKAQIESVLDQLNEREKAVIRMRFGLLDDESDRTLEEIGKELNVTRERVRQIESSAIKKLRSPQYGRILRNYLRI
Protein: Proline-rich nuclear receptor coactivator 2 (B7TWP7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.
Interaction partners:
- Decapping mRNA 1A.
- Nonsense-mediated mRNA decay factor SMG5
- Regulator of nonsense transcripts 1
- Nonsense-mediated mRNA decay factor SMG8
- Nonsense-mediated mRNA decay factor SMG9
- Telomerase-binding protein EST1A
- SMG7 nonsense mediated mRNA decay factor.
- Probable UDP-sugar transporter protein SLC35A4
- m7GpppN-mRNA hydrolase
- Decapping mRNA 1B.
Sequence:
MGGGERYNIPDRPAPKKSQPVSRGKQRSRDQNGVMHSAASGALGVPHHLRRGEKGTSYSWSPEARQAVSVDKKNGSVRFATPYDQNWESHLNKLLSAQCGQNYAGAKFSEPPSPSVLPKPPSHWVSLPMGDHRELMTFQLKSLLKVQA
Protein: Complement C1q and tumor necrosis factor-related protein 9A (Complement C1q and tumor necrosis factor-related protein 9) (P0C862)
Organism: Homo sapiens (Human)
Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Complement C1q and tumor necrosis factor-related protein 9B
Sequence:
MRIWWLLLAIEICTGNINSQDTCRQGHPGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGRPGSPGKDGTSGEKGERGADGKVEAKGIKGDQGSRGSPGKHGPKGLAGPMGEKGLRGETGPQGQKGNKGDVGPTGPEGPRGNIGPLGPTGLPGPMGPIGKPGPKGEAGPTGPQGEPGVRGIRGWKGDRGEKGKIGETLVLPKSAFTVGLTVLSKFPSSDMPIKFDKILYNEFNHYDTAAGKFTCHIAGVYYFTYHITVFSRNVQVSLVKNGVKILHTKDAYMSSEDQASGGIVLQLKLGDEVWLQVTGGERFNGLFADEDDDTTFTGFLLFSSP
Protein: Assimilatory sulfite reductase (ferredoxin), chloroplastic (AtSiR) (EC 1.8.7.1) (Sulfite reductase (ferredoxin)) (Q9LZ66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein with sulfite reductase activity required in assimilatory sulfate reduction pathway during both primary and secondary metabolism and thus involved in development and growth.
Subcellular location: Plastid, chloroplast stroma, chloroplast nucleoid {ECO:0000250}. Plastid stroma. Plastid, chloroplast stroma {ECO:0000269|PubMed:18431481}.
Interaction partners:
- 5'-adenylylsulfate reductase 2, chloroplastic
- 5'-adenylylsulfate reductase 3, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
- Bifunctional cystathionine gamma-lyase/cysteine synthase
- Cysteine synthase 1
- Putative inactive cysteine synthase 2
- Cystathionine gamma-synthase 1, chloroplastic
- Probable cystathionine gamma-synthase 2
- Cysteine synthase, chloroplastic/chromoplastic
- Cysteine synthase, mitochondrial
Sequence:
MSSTFRAPAGAATVFTADQKIRLGRLDALRSSHSVFLGRYGRGGVPVPPSASSSSSSPIQAVSTPAKPETATKRSKVEIIKEKSNFIRYPLNEELLTEAPNVNESAVQLIKFHGSYQQYNREERGGRSYSFMLRTKNPSGKVPNQLYLTMDDLADEFGIGTLRLTTRQTFQLHGVLKQNLKTVMSSIIKNMGSTLGACGDLNRNVLAPAAPYVKKDYLFAQETADNIAALLSPQSGFYYDMWVDGEQFMTAEPPEVVKARNDNSHGTNFVDSPEPIYGTQFLPRKFKVAVTVPTDNSVDLLTNDIGVVVVSDENGEPQGFNIYVGGGMGRTHRMESTFARLAEPIGYVPKEDILYAVKAIVVTQREHGRRDDRKYSRMKYLISSWGIEKFRDVVEQYYGKKFEPSRELPEWEFKSYLGWHEQGDGAWFCGLHVDSGRVGGIMKKTLREVIEKYKIDVRITPNQNIVLCDIKTEWKRPITTVLAQAGLLQPEFVDPLNQTAMACPAFPLCPLAITEAERGIPSILKRVRAMFEKVGLDYDESVVIRVTGCPNGCARPYMAELGLVGDGPNSYQVWLGGTPNLTQIARSFMDKVKVHDLEKVCEPLFYHWKLERQTKESFGEYTTRMGFEKLKELIDTYKGVSQ
Protein: Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein) (Q5EE01)
Organism: Homo sapiens (Human)
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:17610844}. Chromosome, centromere {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:22304917}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:22304917}. Nucleus matrix {ECO:0000269|PubMed:22002061}. Nucleus, nucleolus {ECO:0000269|PubMed:22002061}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. {ECO:0000250|UniProtKB:P0DJH6}.
Interaction partners:
- Centromere protein T
- Centromere protein N
- Centromere protein S
- Centromere protein X
- Centromere protein C
- Centromere protein H
- Centromere protein U
- Centromere protein I
- Centromere protein K
- Centromere protein M
Sequence:
MALSTIVSQRKQIKRKAPRGFLKRVFKRKKPQLRLEKSGDLLVHLNCLLFVHRLAEESRTNACASKCRVINKEHVLAAAKVILKKSRG
Protein: Neuroligin (RH63339p) (Q6NR70)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAQTKIIQSRFLHIYGLLCLGSLMGCIKTIGASIAQQTLADADAPDEAKAKEREAETDADADAEGDAKAETETGKGTREHTNGDAEADARIMATGICIIRLITLKRFLENSKTEEHNQRRQQSATSAASAAPAGATSPRRRHLHYPGHSAVQPGHPEACALLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLCLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAKTKEELQEGDNSKNSSILKLNALMGGGGACGSGPGDIADAYTLSGSVVDSKGGVGVVFGEYSCYDEKTKQLKEGKLLVELPPSSSTGQTSLMIDNWGACSTSTLDLLKTKPGDPIEMVTYSALPSVMESTSAMSSKRGSFVDTTLQFNSPQQFDYAVQSSDQMSFKAIEDAVKAAAGHDSEITRDDDIPEPPPPPRSFLAAQQQQQQQQQQQQTGILRQTGAGGTSTSGSASGSGKKRVHIQEISV
Protein: Uncharacterized protein (Q57Y00)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLDISRFLPKEINAPPTPLVAHGCFIHGSRSCGKTSFAFQAVINTVVGEKERVIILCQEHVLYEKMPKPFTPLEELNEDALTRIEFAYLSSMAEVVRELSSWTVGSSLPALVVVDDEAFLDAGDERLTAVMLSMLENVSAWAKQINGVFHYIVVTNSYPDRGLREKLPFATFPLIWFTFGSVGSVQVAVAGTSQVSTHPLMLEWRDSLTVRSLWSL
Protein: Probable oxidoreductase (Q9I478)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- FAD dependent oxidoreductase domain-containing protein
- 4-hydroxyproline 2-epimerase
- Probable dihydrodipicolinate synthetase
- Hydrogen cyanide synthase subunit HcnA
- Probable oxidoreductase
Sequence:
MSADYDLLIVGAGPAGLAAALAAAPSGARIALVDDNPAAGGQIWRDGPRASLPPRAHQMRQRLAGQANVEHFPATRVVACGPGRRLLLEDPQRGWQVGYRRLVLCTGARELLLPFPGWTLPGVTGAGGLQALAKGGLPLAGQRLVVAGSGPLLLASAASASQCGARLLRVAEQAPARTLAAFAVRLPRWPGKLWQAAGLFARSYRADSYVLAALGEERLEAVRLREGGRVREIACERLACGFGLVPNVQLGQALGYRLDGPALAVDEWQAGSLPDHYAAGECTGFGGSELALVEGAIAGHAAVDERDAARRLWPRRRRWQGFADTLARHFALRAELRQLAEADTLVCRCEDVPLAALAGHAGWTEAKLHSRCGMGACQGRICGSAAQFLFGWTPPAPRPPFSPARLETLARWQGDAG
Protein: Tiny macrocysts protein B (Gamete enriched gene 04 protein) (cAMP pathway regulator tmcB) (Q5FBC3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Regulator of the cAMP signaling pathway specific to sexual development. Controls the levels of external cAMP by regulating the expression of phosphodiesterase pdsA and its inhibitor pdiA.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cyclic nucleotide phosphodiesterase inhibitor
Sequence:
MSSTKSGSSKYSSGSSISLIMGFSRSLEKGSFGVLYAMIKGNTFPRILTILSMLIEFCQLSSFGFKHQYPWGGDAGYYLKRIMSPVSHPSDVFGYLGFTILFWIAVGLLILGFLNIWYVAYQFYRGKIANIWIIRTLRWFVSFSVAVLFIPIISLLLIGLDCEGSSEGTILRKFDNETIQCFRGANLPIAVISIILIVVFSIVAFTSSATYYEYDTNVKSRFSKPHARFDVTVLFAKFVFAFFNSLVDFVPWLTSITFFVFMVILTFGSIIVLPYNNQRLNQVRSGFYTVVLWVSFMTLVTMGINDETSPATCYITIVGVFFAFPIGFFSNMFYFKWLSSKVSDIQILNQSPSMDLKDANKKGKRNSVEKESSPTSKVTWGKQPITLGSKRQIIFPFFKKKFVMSFFVEIMARSILNNNNEGVSSSSNESIERANNLYQCGLQYFPNSDLLWMAYCNFLFTVRKDRHIGYAALEKLRRMKPSFDVRFFIYQRDKEREQIMDSDLRGPEHTGKIQDFVSYMEFKKLYYGAKRHHVKCLNYIKRFWGHLLHETVDLHRLSDLSGRIATTENKANESYERLLALNPNSVRVLRDYSQFLEEVVKDKESSYKLQKKAEAIEDIMSKSQTTDFKISDIKAIDSDEDDIEKTLQEPTAIQLAKIDADIEKSGSKSGSSKSKDDSSESSSSSKGRRGKYKEFQQSNAINKLSWLMIGTTCCCIIFLIVVLVVFRGLEVKHTNAYQGIISITDCANEAVQMGMHLNAMQAYALVAGVGNNTVEASLIEIARRRALVKRGIIIMKNIHDAIYWGEGNPVSYVGDNLSQLKARDGYDIFDIGSVIFTFDQFNRSSTLLDNKQMIELYSQPSVNMSVLVAPPGSNTTSLYTQTYNAWKAGNAFIESAMLASDVTFDELRYSVNQNPNFKFVTINAPVIMPDIYNKVQTAYIDSLVSDITGTLDAILYTWCGIFAVLFLICAVLFRPIVRKISREKIRTLVLFSLAPKDVVVKLSTKKIKMVSLDSGSERDNLFDTTDDDGRDDHLGEDDNNIQTPVGDNNNNNNNNNNNNNNNGSISSNVTKSDGEIGSDGVRSSSGSNVLNTSSPYRDRRPLMDSTSVLASTATLNNRNVRLQAKDEEITNGGGERKGSDATRTALSEDKKYGWDGKSKRNLNKKSLKSILGRLHWSYILATFLLFGFITMGIWVTFTVVFNNSQSGYTLGKSCSRSLNSRVINYYVAELYTYSQYVSTQNMVDAITELQSSHQSLPYLEEVRPLMEGSYGCWALNKSTCLPPSSMYYEEVNSGLDRVVDSLAKKAINLAYTDQAALLDSPDLQWFLALIDYIFIGLDTATFTYFDYFLEKQEWANTVLTAILSVSCVILLVVHVVLFRPFMNHLRIQHIHTLALLRLAPDDIRYMEVSDKVIDED
Protein: Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (E1BEJ3)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|HAMAP-Rule:MF_03061}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Elongation factor Ts, mitochondrial
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein uS7m
- Elongation factor Tu, mitochondrial
- Ribosome-recycling factor, mitochondrial
- Ribosomal protein
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL14
Sequence:
MRLLGAAAAAAVGRGPLPRVPAALGWQGKQANWKICRWCSSGVIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVNRQMRRYNVPFLTFINKLDRVGSNPARALQQMRSKLSHNAAFVQLPIGLESDFKGIIDLIEERAIYFDGDFGQIVRYGEIPAEFRAAAADHRQELIECVANSDEQLGEMFLEEKTPSISDLKLAIRRATLNRSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNQDDSQEKTKILMNPKRDSSHPFVGLAFKLEAGRFGQLTYVRNYQGELKKGDNIYNTRTRKKVRVQRLVRMHADMMEDVEEVFAGDICALFGIDCASGDTFTNKDNSGLSMNDLEKFSKGIGRFTREDPTFKVHFDTDSKETIVSGMGELHLEIYAQRMEREYGCPCITGKPKVAFRETITAPVPFDFTHKKQSGGAGQFGKVIGVLEPLDPENYTKLEFSDETFGSNVPKQFVPAVEKGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANTALCILEPIMSVEVIAPNEFQGPVIAGINRRHGVITGQDGIEDYFTLYADVPLNNMFGYSTELRSCTEGKGEYTMEYCRYQPCSPATQEELINKYLEATGQLPVKKGKAKN
Protein: Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor) (P97458)
Organism: Mus musculus (Mouse)
Function: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Pituitary-specific positive transcription factor 1
- Catenin beta-1
- Growth hormone-releasing hormone receptor
- Prolactin
- Prolactin-6A1
- Prolactin-5A1
Sequence:
MEAQRRSHQEKQTKGHACGRSLPEPRVASGTLISTVDRSSEAYRRLSGTELGRPKLCPQRGRPHSRRRHRTTFNPAQLEQLESAFGRNQYPDIWAREGLAQDTGLSEARIQVWFQNRRAKQRKQERSLLQPIAHLSTATFSGFLPESSAYPYTYGTPPPPAPCFPHPYSHSLPSQPSTAASLALPPQPEDWYPTLHPAPTGHLPCPPPPPMFPLSLETPKSWN
Protein: Aminopeptidase O (AP-O) (EC 3.4.11.-) (Q8BXQ6)
Organism: Mus musculus (Mouse)
Function: Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:17803194}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305|PubMed:17803194}.
Interaction partners:
- Angiotensinogen
Sequence:
MDIKLDPSRDDLPLMANTSHMLVKHYILDLDVDFGNQVIEGNIVLFFGDGNRFKNQSRSTQETFQMESEEADIFRTAEPCHVPEMDSSTFSPKMGHRECAVCGKGDQDAFDNDGNHDNQERDSEISSSKYCCDTGNHGKRDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTKAPKLLATPEKLRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGELLIDSDNWSLRIRKTGTSTPADFPRAIRIWYKTKPEGQSVAWTTDQNGRPCVYTMGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTPLREGYMSWHYYVTMPMPASTFAIAVGCWTEMKPKASPPDDLMTEHSLPLSPSEADLRYDNTCNHMEYPCRFQSASAASQDIIPYRVFAPVCLEGACQEALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNFPSLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHSWFGLAIGARDWTEEWLSEGFATHLEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELRNSPEGMQVLRPNKEETGHVSASGASVVKHGLNPEKGFMQVHYLKGYFLLRFLTRTLGEKIYFPFLRKFVHLFHGQLILSQDFLQMLLENIPENKRLGLSVENIVRDWLECSGIPKALQEERKAEDCSPSRLARQVGSEVAKWIRVNRRPRKRKRGKREVAFEKLSPDQIVLLLEWLLEQKTLSPQTLHCLQQTYHLPEQDAEVRHRWCELVIKHKYTKAYNQVERFLLEDQAMGIYLYGELMVSEDARLQQLAHRCFELVKEHMDRASAQVVTEMLF
Protein: Rieske domain-containing protein (A8J9Y1)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Interaction partners:
- Cytochrome b6-f complex subunit 4
- Cytochrome f
- Cytochrome b6
- Cytochrome b6-f complex subunit 5
- Cytochrome b6-f complex subunit PetN
- Cytochrome c1
- Cytochrome c-553
- NADH:ubiquinone oxidoreductase 24 kD subunit
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 3
Sequence:
MAMLSSRRVAAPAKASAIRRSRVMPVVRAAAASSEVPDMNKRNIMNLILAGGAGLPITTLALGYGAFFVPPSSGGGGGGQAAKDALGNDIKAGEWLKTHLAGDRSLSQGLKGDPTYLIVTADSTIEKYGLNAVCTHLGCVVPWVAAENKFKCPCHGSQYNAEGKVVRGPAPLSLALAHCDVAESGLVTFSTWTETDFRTGLEPWWA
Protein: Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2) (Q8BFZ6)
Organism: Mus musculus (Mouse)
Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:Q9BXS1}.
Interaction partners:
- Diphosphomevalonate decarboxylase
- Geranylgeranyl pyrophosphate synthase
- Farnesyl pyrophosphate synthase
- Isopentenyl-diphosphate Delta-isomerase 1
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Squalene monooxygenase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Squalene synthase
- Lanosterol 14-alpha demethylase
- Mevalonate kinase
Sequence:
MFQASKTHLDELQLKRLEEMCIVIDKQDQIIGADTKKNCHLMENINKGLLHRAFSVVLFNMKNELLVQQRADAKYTFPGHFTDSCSSHPLYVPEELEEKDALGVRRAALRRLQAELGISQDQISIKDIIFMTRKYHKCQSDAIWGEHEIGYLLLVRKDLMLNPDTREVRRCCYMSQKDVQELLDREARGEEKITPWFRSMVEDFLFSWWPHLEDVSSFVEPDKIYGL