wanglab/gogpt-training-data huggingface dataset:
Protein: BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5) (Q5QJC9)
Organism: Rattus norvegicus (Rat)
Function: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN.
Subcellular location: Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes. {ECO:0000250|UniProtKB:Q8CI32}.
Interaction partners:
- Cyclin-G-associated kinase
- BAG cochaperone 2.
- Heat shock 70 kDa protein 4
- Heat shock cognate 71 kDa protein
- Ras-related protein Rab-7L1
- STIP1 homology and U-Box containing protein 1, isoform CRA_b.
- Heat shock cognate 71 kDa protein
- E3 ubiquitin-protein ligase parkin
- BAG family molecular chaperone regulator 1
- Serine/threonine-protein kinase PINK1, mitochondrial
Sequence:
MDMGNQHPSISRLQEIQREVKSIEQQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQDTERLLKELEQNANHPHRIEIKNIFQEAQALVKEKTVPFYSGSNCVTSEFEEAIQDIILRLTHVKTGGKISLRKARYHTLTKICAVQEIIEDCVRKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLMADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADNTHAFDLGQNHSIIKIENVLKRMREMKNELLQAQSPPELYLRSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYLDLKEALEKRKLFPCEETPPHKAVWNVLGNLSEIQGEVLSFGGNRTDKNYIRLEELLTKQLLTLDAVDPLGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY
Protein: Homeobox-leucine zipper protein ATHB-4 (HD-ZIP protein ATHB-4) (Homeodomain transcription factor ATHB-4) (P92953)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor PAR1
- Transcription factor PIL1
- Transcription factor HFR1
- Homeobox-leucine zipper protein ATHB-8
- Transcription factor PIF5
- Transcription factor PIF7
- Transcription factor PIF4
Sequence:
MGERDDGLGLSLSLGNSQQKEPSLRLNLMPLTTSSSSSSFQHMHNQNNNSHPQKIHNISWTHLFQSSGIKRTTAERNSDAGSFLRGFNVNRAQSSVAVVDLEEEAAVVSSPNSAVSSLSGNKRDLAVARGGDENEAERASCSRGGGSGGSDDEDGGNGDGSRKKLRLSKDQALVLEETFKEHSTLNPKQKLALAKQLNLRARQVEVWFQNRRARTKLKQTEVDCEYLKRCCDNLTEENRRLQKEVSELRALKLSPHLYMHMTPPTTLTMCPSCERVSSSAATVTAAPSTTTTPTVVGRPSPQRLTPWTAISLQQKSGR
Protein: Vps72/YL1 N-terminal domain-containing protein (Q385I5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDGVDDSRWNVADDRPRRANRGNMLQNLLEKGLNSDEEKFLNNLSDATSDSTFTTSEEAVDEIDSDFSDEEIEGVLEGTTIVTDAALEREERLERKKERQKSMRHGKLLGRGAAVDREQVVKLRLRPPSTIPLEDRLRAAHERAKEVRATAARRSTGGIGAMGSVTHEMEAAAKKRRGYHSRGRGLTKNGDENSVANATDEGEVIQRVRYTSSASVLELYGVPVVISFSRCLPTMFTSGAGSN
Protein: Elongation factor 1-beta (EF-1-beta) (P24534)
Organism: Homo sapiens (Human)
Function: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
Interaction partners:
- Elongation factor 1-gamma
- Elongation factor 1-alpha 1
- Elongation factor 1-delta
- Elongation factor 1-alpha 2
- Translationally-controlled tumor protein
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein eS1
Sequence:
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKRLREERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI
Protein: Transcription factor HY5-like (HY5 homolog) (bZIP transcription factor 64) (AtbZIP64) (Q8W191)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12023303}.
Interaction partners:
- E3 ubiquitin-protein ligase COP1
- Transcription factor HY5
- WD repeat-containing protein RUP2
- Protein SUPPRESSOR OF PHYA-105 1
- WD repeat-containing protein RUP1
- Protein SPA1-RELATED 2
- Phytochrome A
- Transcription factor PIF3
- Transcription factor HFR1
- Transcription factor LAF1
Sequence:
MSLQRPNGNSSSSSSHKKHKTEESDEELLMVPDMEAAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH
Protein: Anion exchange protein (Q3ZMH2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Membrane {ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362035}.
Interaction partners:
Sequence:
MSAGKRVEDEAVLDRGASLLKPLCDQEEVEGHHTIYIGVHVPKSYRRRRRRRRRTSHKDRKEKVSENTSDRSDAENNEEASNSILKPLISPAAERIRFILGEDDDSPAPPQLFTELDELLSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHSLFELRTCIEKGTIMLDLEASTLPGVVEMITDSQIESGLLKADLKEKVMYTLLRKHRHQTKKSNLRSLADIGKTVSSASRLFSTPDNGSPTTAHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYAGGDSTQMNGDTPHSGGHGGGGHAVGDELKKTGKFCGGLILDVKRKVPFFFSDFYDSLHIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVPESFLGTVVTGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRENDFDYLEFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMLKLAHYYPINSDFKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYTTDPRMNATWSSLSKKECLKYGGELVGKACEFVPDITLMSFILFFGTYTCSMCLKKFKTSPFFLTTVRKLISDFAIILAILIFCGVDALVGVETPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLAASVPALLVTILLFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPAKHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKSTVAAIIFPVMILALVAVRKALDYIFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKQGSIDSDMEDSDYPYNENVPSIKIPMDMMEQEPFLGDKASDREKSASILDRYSSC
Protein: Aquaporin-3 (AQP-3) (Aquaglyceroporin-3) (Q8R2N1)
Organism: Mus musculus (Mouse)
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q92482}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000269|PubMed:16641094}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}.
Interaction partners:
- Aquaporin-12
- Aquaporin-11
- Lens fiber major intrinsic protein
- Vasopressin V2 receptor
- Aquaporin-8
- Aquaporin-4
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Aquaporin-5
- Aquaporin-1
- Aquaporin-2
Sequence:
MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYALAQTLGAFLGAGIVFGLYYDAIWAFANNELFVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGRHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSTEEENVKLAHMKHKEQI
Protein: Beta-2-microglobulin (F5H6I0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPADIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
Protein: Kinesin-like protein vab-8 (A8DZ45)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLRGHTPFLSASLKLYDELCSPPSSSRASPAPPAAFGGKTSEKREDFGIMIAQPSIPLMKAKSKYNLDDGKMKQIMQWMETSEAPPILFSSPCYENSATSVEELRECVGILSHPLEDIIEQEEESMRTSTATTGGSKKDHPLRILSKQDLNVEPEIKDKQEENELELVMAASLSSMRSHDILAKLEAMRNAQNGNSVQNIGNSQSNTDMDVSEMDVYRRASHLEEYAMQRVREIEENKLKNKKKIKLGLNCCQQQSMISSGSTVVDWSQIERKKEKEREVHEEEMRKEMLRERRAKLKITELEIKRERNLIDKELDDKKGIANSIARQLQHFSLSPCRGGRTHRSVSTHRIDPPNASLPSTPTMSHKKVIGGSLAKLSASGASGSTGAPPSPALGYHQSLPRHSKLPTSVNGRRASAERERKSNKASRNSCSKERKISGSKEELQWRSPYAQMTSPKSYGGPGTSSSGRGSSAPGSDFETPVVSTTEKSANGTIPRSKRQSYSASSGYESANDYHIYSTTNKKPHILDKKRNEEKLSLVRQADEIRHRQWQLKKELEEAKRAIGQEDDAKMIANSSDQRLNGLSRTTMIDAMLQENRILEKRLVACRNHSMLVTTFI
Protein: MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) (Q8BGT6)
Organism: Mus musculus (Mouse)
Function: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
Subcellular location: Recycling endosome membrane {ECO:0000250|UniProtKB:Q8N3F8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N3F8}. Late endosome membrane {ECO:0000250|UniProtKB:Q8N3F8}. Cell junction, adherens junction {ECO:0000269|PubMed:33972531}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8N3F8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N3F8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8N3F8}. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6. {ECO:0000250|UniProtKB:Q8N3F8}.
Interaction partners:
- EH domain-containing protein 1
- Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
- Ras-related protein Rab-8A
- Ras-related protein Rab-13
- Ras-related protein Rab-35
- Ras-related protein Rab-12
- EH domain-containing protein 3
Sequence:
MAGPRGALLAWCRRQCEGYRGVDIRDLSSSFRDGLAFCAILHRHRPDLLDFQSLSKENVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFTSSGQAAASPPKPGKDPAPPSPTSTSPAVQPGEEAQGDDLSPDSLSEQGKQQPPSSACAACGQRVHLVQRYLAEGRLYHRHCFRCRQCSSTLVPGSYSSGPEEGTFVCAERCTRLGPGSRSGTRLLSQQRQQPAAAEAKDAEDNDPSLSVAAVAEADRLQASSEVQFHTPTKPPLPSKPQELASPPGGRPTPAPRKASESSALTPPTPRPRSSLQQDGTVEQSVSSGLVNGRLQEPPVPKPRGTPKLSERMAAPRKDPPWITLVQTEPKKKPAPQPPSSGPGPLSQAYRQVEDGGLEEQTQKSSGTEPEPKPYNPFEEEEEEEGEPAPPVPSPSLAPPVPSPSPAPPVPSPAPAPSEATPKSLHPWYGITPTSSPKTKKRPAPRAPSASPLAIHASRLSHSEPPSATPSPALSVESLSSESSSHTANAEPLEPPAVPKSSSDPAVHVPGTPGTSGNSVTPSANSSLSSSGELGQPSGEQMLQARTKGSAGTHSTKPFSGATPTPFLLAGDRNPAPPVGSASPQLQIKSSCKENPFNRKPSPSASPTVRKATKGAKPVRPPAPGHGFPLIKRKVQADQYIPEEDIYGEMDNIERQLDALEHSGVLLEEKLRGGANEGSEDDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEFELRCLLNKPEKDWTDEDRAREKVLMQELMTLIEQRDAIVNCLDEDRQREEEEDKMLETMIKKKDFQREAESDSKKKGKFKTIKVLKFLGNKREAKSKAPGDKS
Protein: Salicyl-AMP ligase / salicyl-S-ArCP synthetase (EC 6.2.1.-) (Mycobactin biosynthesis protein MbtA) (Salicyl-AMP ligase) (Sal-AMP ligase) (EC 2.7.7.-) (Salicyl-S-ArCP synthetase) (P71716)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the initial steps of the mycobactin biosynthetic pathway. Catalyzes the salicylation of the aryl carrier protein (ArCP) domain of MbtB through a two-step reaction. The first step is the ATP-dependent adenylation of salicylate to generate a salicyl-AMP intermediate. The second step is the transfer of this activated salicylate to MbtB to form a salicyl-ArCP domain thioester.
Interaction partners:
- Phenyloxazoline synthase MbtB
- Salicylate synthase
- Acetyl hydrolase MbtJ
- Polyketide synthetase MbtC
- Protein MbtH
- Polyketide synthase Pks13
- Mycobactin import ATP-binding/permease protein IrtA
- L-lysine N6-monooxygenase MbtG
- Putative isochorismate synthase MenF
- Peptide synthetase MbtE
Sequence:
MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALCRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGEEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
Protein: Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.171) (16S rRNA m2G966 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase) (P0ADX9)
Organism: Escherichia coli (strain K12)
Function: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.
Interaction partners:
- Uncharacterized protein YhhL
- Signal recognition particle receptor FtsY
- Ribosomal RNA small subunit methyltransferase C
- Ribosomal RNA large subunit methyltransferase G
- Ribosomal RNA large subunit methyltransferase K/L
- Phosphopantetheine adenylyltransferase
Sequence:
MKKPNHSGSGQIRIIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNWLAPVIVDAQCLDCFAGSGALGLEALSRYAAGATLIEMDRAVSQQLIKNLATLKAGNARVVNSNAMSFLAQKGTPHNIVFVDPPFRRGLLEETINLLEDNGWLADEALIYVESEVENGLPTVPANWSLHREKVAGQVAYRLYQREAQGESDAD
Protein: Brevinin-2Rf (C0HL00)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000269|PubMed:28012108}.
Interaction partners:
Sequence:
GIFLNALKNFAKTAGKGVLQSVLNTASCKLSKQC
Protein: Glycoprotein C (Membrane glycoprotein C) (Q6F4H9)
Organism: Equid alphaherpesvirus 1 (Equine herpesvirus 1)
Subcellular location: Virion membrane {ECO:0000256|ARBA:ARBA00004381}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004381}.
Interaction partners:
Sequence:
MWLPNLVRFVAVAYLICAGAILTYASGASASSSQSTPATPTHTTPNLTTAHGAGSDNTTNANGTESTHSHETTITCTKSLISVPYYKSVDMNCTTSVGVNYSEYRLEIYLNQRTPFSGTPPGDEENYINHNATKDQTLLLFSTAERKKSRRGGQLGVIPDRLPKRQLFNLPLHTEGGTKFPLTIKSVDWRTAGIYVWSLYAKNGTLVNSTSVTVSTYNAPLLDLSVHPSLKGENYRATCVVASYFPHSSVKLRWYKNAREVDFTKYVTNASSVWVDGLITRISTVSIPVDPEEEYTPSLRCSIDWYRDEVSFARIAKAGTPSVFVAPTVSVSVEDGDAVCTAKCVPSTGVFVSWSVNDHLPGVPSQDMTTGVCPSHSGLVNMQSRRPLSEENGEREYSCIIEGYPDGLPMFSDTVVYDASPIVEDRPVLTSIIAVTCGAAALALVVLITAVCFYCSKPSQAPYKKSDF
Protein: Serendipity locus protein H-1 (Protein pourquoi-pas) (Protein wings-down) (P15619)
Organism: Drosophila melanogaster (Fruit fly)
Function: May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte.
Subcellular location: Nucleus {ECO:0000269|PubMed:1592256}.
Interaction partners:
Sequence:
MEGGKGEGKRMKEEAPSKKLPPKIYGGDAGTPTKAAHDEILSSLLRINNFDSISSIKDESLDIDLSACVTISSASLVNGNSLSSTDFWRVLDESAQNNTELNLSSDVCRDDLAATSSSTVPSTLTSDNHSSSEFSVTFLRPEPPNAFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMPQSQLLQRKPKLPAATAVRLKVFKEEPPEEKHPPEQVVTKVEVCESELLPPSFTIFQQAKSAESVADAASMPPPAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGEHLENIPSYCSKKSTTNKAQKAAAAAAAAAAASSAVNPNELSASSELKAKANLTSTAAPAPAKQARKKKQPQQATLAALGITLPAGTALQQVHPVPLAQQHQQELTTVLVPLAPPAPKQTKAKRERKQLAPKQLQQKPQLLQQGQPQQSSLEPIPAVPQIKKEPVQTQGPFLDLHGLSLTSAEELIMEQALEMEECGLYDAPNANTEMGTSDNAISDSAAALHFQIKNELPDELLPDDDFLPCKPSDRLPCPSLESSPFSSPASMELTAVSCASSVAISTNALPVRSGNYYLPAFTLNAHGKLSSTGNGVQSVTTSLAQTPSVSMVNVPLLVRSNQMLPSVDTLLFTNQTGGSRFFAGKSATAATPHLT
Protein: Nuclear factor I family protein (Q5H9N3)
Organism: Caenorhabditis elegans
Function: Probable transcription factor which recognizes and binds the palindromic sequence 5'-TTGGCANNNTGCCAA-3' present in promoters. Plays a role in locomotion, pharyngeal pumping, egg-laying, and life span.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00436, ECO:0000269|PubMed:18651662}.
Interaction partners:
- Non-structural maintenance of chromosomes element 4
- ShKT domain-containing protein
- Nuclear receptor
- Secreted protein
Sequence:
MEPHLKIDVSSASGSTTTGATASTSEAPQDSQAQQTMPPPSSDWSNQFNSPEAVSPKANGIKCFSPYSQEDMGPFVEQLLPFVRASAYNWFHLQAAKRRHFKEFDKKMCASEENAKLAELQNDRDELKVKWASRLLGKIKKDIQNDDKEAFISAINGSEPNKCIISVADQKGKMRRIDCLRQADKVWRLDLVTIILFKGIPLESTDGERLERSEACVHPLCINPFHMAISVRGLDVFMANYLKDVDTKITLTYPRNDELSDTVMVKQEPGEQTIVAPHAVLGTSSTHTRVWETNSERNAETIIITYDPQKACHTYFGGRATLAQQSLSAGNTYMVNKTAVDNNFFNAKRSVLCLPPPPIQNCFPYPIAGTSDSQQMDMSEDSNDGPSEKRSRDISSHDSPNSSTNDEVRRIVESGTEKLVLGSSIWAAPGQFSRTQQNQGAPGTSRQVRPLPDFQSQDSARSPGAFRSTAKPVCRMTVNTGNHGDVGVVVVDERNREHVIHAQHIVNALSSLRTTPSMRESPVGRKRMHPHTSNSFEFLNCNQEMNKNEGALGSDISPTHTAVSNLISRESSGYMASPTKFTTARGDTTSFSKIFQKIEEKHLQHNQPSTSYCNSQIQPPILSSKPVDSSVKLIAPVAVKPIMSGCNSIIPSPITTPRITPSFRMLEDDSLINVLGQLAHSNDGTTLNDSFIQHLIDTNSRSPLLSSGNAFSALSMGAVSGLVPGNSIHRPDSSASNGSNSLGVAMGLAVPQNIALAVQQTQNAMSPLHQIRVSVGAPPACSPSSSNSSLGAANQAPVSNTPQDPNAPKLPTDFSHALRNEKK
Protein: Lymphocyte antigen 6 complex locus protein G6d (Q9Z1Q3)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000269|PubMed:17008713}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. Cell projection, filopodium {ECO:0000269|PubMed:17008713}.
Interaction partners:
Sequence:
MNSQLVGILLSALLGVALGHRTRCYDCGGGPSNSCKQTVITCGEGERCGFLDRKPQPSSEQAKQPSATLSHHYPACVATHHCNQVAIESVGDVTFTTQKNCCFGDLCNSAVASSVTPLCILAAAVTTLAWLLPGL
Protein: Secreted isochorismatase effector Isc1 (EC 3.3.2.1) (G2X4M1)
Organism: Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
Function: Secreted isochorismatase required for full virulence of V.dahliae. Suppresses salicylate-mediated innate immunity of the host by disrupting the plant salicylate metabolism pathway via hydrolysis of its isochorismate precursor.
Subcellular location: Secreted {ECO:0000269|PubMed:25156390}. Host cytoplasm {ECO:0000269|PubMed:25156390}. Host nucleus {ECO:0000269|PubMed:25156390}. Note=Lacks a signal peptide and uses an unconventional secretion pathway for delivering effectors which plays an important role in host-pathogen interactions. {ECO:0000269|PubMed:25156390}.
Interaction partners:
Sequence:
MSSFRSMLGVPPSTASTQDSVLVIIDAQGEYAEGKLKISNIEASRPNISSLLEKYRAANAPIVHVVHETPAGAPLFTQGTKLAEIFDELTPKEGEAVVTKHHPGSFADTNLQEILEKSGKKKIVLVGYMAHVCVSTTARQGAQRGWDVIVAEDAVGDRDIPGVDAAQLVKVALAEIADVFGTLVSSKDIN
Protein: Glutathione S-transferase U27 (AtGSTU27) (EC 2.5.1.18) (GST class-tau member 27) (Q9LZG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione synthetase, chloroplastic
- Glutathione S-transferase DHAR2
- Anthranilate N-hydroxycinnamoyl/benzoyltransferase-like protein
- Uncharacterized protein unannotated coding sequence from BAC F9L11
- Proline-rich extensin-like family protein
- Probable pectate lyase 12
- Glutathione S-transferase T2
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase DHAR3, chloroplastic
- DNA polymerase epsilon catalytic subunit A
Sequence:
MSEEEVVVLNFWPSMFGARVIMALEEKEIKFEYKEEDVFGQKTDLLLQSNPVNKKIPVLIHNGKPVCESNIIVEYIDEVWKDDKTLRLLPSDPYQKSQCRFWADLIDKKVFDAGRRTWTKRGKEQEEAKQEFIEILKVLERELGDKVYFGGNDNVSMVDLVLISYYPWFHTWETIGGFSVEDHTPKLMDWIRKCLTRPAISKSLPDPLKIFDRVTQIIKVHEFFYGY
Protein: Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) (P45352)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P04818}. Cytoplasm {ECO:0000250|UniProtKB:P04818}. Mitochondrion {ECO:0000250|UniProtKB:P04818}. Mitochondrion matrix {ECO:0000250|UniProtKB:P04818}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04818}.
Interaction partners:
- Dihydrofolate reductase
- Thymidine kinase, cytosolic
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Methylenetetrahydrofolate dehydrogenase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Folylpolyglutamate synthase
- dTMP kinase
- Methylenetetrahydrofolate reductase
Sequence:
MLVEGSELQSGAQQPRTEAPQHGELQYLRQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
Protein: Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1) (P36402)
Organism: Homo sapiens (Human)
Function: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
Subcellular location: Nucleus.
Interaction partners:
- Catenin beta-1
- Axin-2
- Junction plakoglobin
- Axin-1
- C-terminal-binding protein 2
- C-terminal-binding protein 1
- Adenomatous polyposis coli protein
- Serine/threonine-protein kinase NLK
- Adenomatous polyposis coli protein 2
- Transcription factor 7-like 1
Sequence:
MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTETNWPRELKDGNGQESLSMSSSSSPA
Protein: Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) (Q07960)
Organism: Homo sapiens (Human)
Function: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
Subcellular location: Cytoplasm.
Interaction partners:
- Transforming protein RhoA
- Cell division control protein 42 homolog
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
- Ras GTPase-activating protein 1
- Rho-related GTP-binding protein RhoC
- Cdc42-interacting protein 4
- Nuclear distribution protein nudE-like 1
- Angiomotin
- Ras-related C3 botulinum toxin substrate 1
- Actin nucleation-promoting factor WASL
Sequence:
MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL