wanglab/gogpt-training-data huggingface dataset:
Protein: D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1) (Q02338)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q02337}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q02337}.
Interaction partners:
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Dehydrogenase/reductase SDR family member 6
- Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Acetoacetyl-CoA synthetase
- Acetyl-CoA acetyltransferase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
Sequence:
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Protein: Prostate and testis expressed protein 4 (PATE-like protein B) (PATE-B) (P0C8F1)
Organism: Homo sapiens (Human)
Function: May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.
Subcellular location: Secreted {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:18387948}.
Interaction partners:
- Prostate and testis expressed protein 2
- Prostate and testis expressed protein 3
Sequence:
MRKMNTLLLVSLSFLYLKEVMGLKCNTCIYTEGWKCMAGRGTCIAKENELCSTTAYFRGDKHMYSTHMCKYKCREEESSKRGLLRVTLCCDRNFCNVF
Protein: Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] (Q9BZ23)
Organism: Homo sapiens (Human)
Function: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC).
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12554685, ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:17825826}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23152917}. Nucleus {ECO:0000269|PubMed:23152917}. Note=Localizes predominantly to the mitochondria and to a lesser extent to the nucleus. Found in both the mitochondria and the nucleus throughout the cell cycle, with the exception of the G2/M phase when it is restricted to mitochdondria. {ECO:0000269|PubMed:23152917}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:12554685, ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
Interaction partners:
- Bifunctional coenzyme A synthase
- Phosphopantothenate--cysteine ligase
- Phosphopantothenoylcysteine decarboxylase
- Pantothenate kinase 3
- 85/88 kDa calcium-independent phospholipase A2
- Pantetheinase
- Pantothenate kinase 1
- Ferritin light chain
- Pantetheine hydrolase VNN2
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sequence:
MRRLGPFHPRVHWAAPPSLSSGLHRLLFLRGTRIPSSTTLSPPRHDSLSLDGGTVNPPRVREPTGREAFGPSPASSDWLPARWRNGRGGRPRARLCSGWTAAEEARRNPTLGGLLGRQRLLLRMGGGRLGAPMERHGRASATSVSSAGEQAAGDPEGRRQEPLRRRASSASVPAVGASAEGTRRDRLGSYSGPTSVSRQRVESLRKKRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFLTIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELLKIP
Protein: Choriogonadotropin subunit beta 7 (P0DN87)
Organism: Homo sapiens (Human)
Function: Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Subcellular location: Secreted {ECO:0000269|PubMed:16123088}.
Interaction partners:
Sequence:
MEMFQGLLLLLLLSMGGTWASREMLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ
Protein: Cytochrome P450, family 2, subfamily d, polypeptide 22 (A0A2R8VKC7)
Organism: Mus musculus (Mouse)
Subcellular location: Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Interaction partners:
Sequence:
WRQRWTAHYPPGPMPWPVLGNLLHMDFQNMPAGFQKLRGRYGDLFSLQLASESVVVLNGLTALREALVKHSEDTADRPPLHFNDLLGFGPRSQGRVQQEIDEVIGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLIPKGTTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSISVPDGQPQP
Protein: MIF4G domain-containing protein (H2L032)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
METLQTENQLIGELKAPATTKKPTNRPAMQIYRPPGLRSDGSSSTTAVTTTSSTKPKPAAGQKLSSSECDTNVNSQILKEDNFQKIIIRKIAASRRVHVPARALPTMSRLMIGTRTEV
Protein: Histone gene-specific epigenetic repressor in late S phase, isoform A (Histone gene-specific epigenetic repressor in late S phase, isoform E) (Histone gene-specific epigenetic repressor in late S phase, isoform I) (Q9VWC0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVSKKRSNAAERVQRSTATAAAAAAAAAAAATASSTQGKKRPGKQTKASGGGGDEADDKKSASKTDSAAKKPAKDPTGSSGVSTATTEGGAGNGGGKQTTSTTTSSTSSTTAPSASASASASNSLKLSPEERHEDGKARAINKMLKSLDIKIHGFDNLLPSGEERLNDGVLKSSISENVKTKSRAAAVKVISSLNPGKMPPVKRVRPSPEPVREKVAEKPAEKVLDKEKPKAEQQITPPPAPEESPASKVPKKTVQQAKKAKVESSLVQATVLTTTSAATSAPSSASTSKHTSTKNPGKKSAHSEQMPKKELSKLAKMGKPKKEANLVKSTARLPDSNTESVQMELEEIVSTPTVTPTPSATPTATPTPTATPTLTPTPTATRTRTPTPTLTPTPTPTSTPSSTAIAAGQPAPPPPPPGGAPKQRPKVKYTKTSAGSKGRMQQALNQKAPAASWSGAKDIYDFKSGSEDEEPIKMVLPSLKELREFSDEDNKPLKLFERQAEKTKVQVQDEEEQPLVKKEEKPPSEKEVKVKSKEKEKEKEKDVDPLSNAQQSEPAAKHTTSTSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKGKAAAAKEPPPSGSSAESSSSEDERKLSAYSGPKRHRMASLNALAKVQCLYENESRTAHELGLSKATQQPPRIRTLDGSDDDNHKDSPRHGDTDRDKGSVSPPHTSAAPPAAPIAPPKEAEPRRELRYVPGGRGVGKHWEFDSDSETEELQLQQTLPPVKKKKLPKKAPPKKVASSETDAKRKKKSVQVEESDDEEAKEKEKEKEKPKPPKQLPKKRKTAFTEELIGDYKGILARKRMASLNASAIVAATYEVERHLDKNLASDCSSFESYDELDTMPTTTSKVTSAAAIKTEVIHIKKEPKESKESLRERERERESERRRERDNELKDSTVGKMSSHSIIEESNDSKYSKETKETNTDTTITTTGYRDSAASTKDAKDCSRPTSSSVVIVQDTDVTITGVYVNASNGAAQEAYCKMQYRVQSSVTEERVLRPGSVEPPKSYTPLSALSSMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHALPDHHGPPPPSYAAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHAAHAHHYQQAAEYHGGPPPPPHHYGGPPPQGHYGPPPGAPVPVPVAVPNTVTVPPERCDVGSPPPSYRASAYPPPSSVGMPPPTLGGGSSAFCAPSPLHHHQHQHQQPGPGVGPPHHDPSGYYQPAGPLISPHVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQSQSQGQSHGHAHSHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGYPPNYYAPYPGEVMCYSPPTYPPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYYQHAGPPPPHELYEQQPPPPPVSSGSVSGPAQQQPPTSSPASVGAAGAGTAGAPSGSQLVPAHQQQHQQQHLEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIISNIDQSSSCSSSMLLSATSNSNIGGGSSSSSSSSSSTTLPACSSATTTTTASALTTSRGPVKNVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPPESYCASDEKLLDDQEQEAELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAKLEAEPEMPFVLKAEIKAETKIKIEHDGEAQASTHISQLPDLKPTIKTEPEQELEQEAASVPSVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNLLALSSGNKKTKTNNSYKSLIKQAEPKSYLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRMRLQRREQQQQRRQQREAAAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNSSATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDHRGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAAATTIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTASQQQNQQHSDEQHQFLVPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNRKRQRHRPGGVSYELDVTQPPATKANVVPKWNNGWMWAGKAFQGAVFLNSDDPLVLRTCYPAMRHVEGDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDVEDVSIVPRRPSIATAPGFPVRTVPEHTNPELVMFCRRAYEFRTRRLLKLPHKNGLVCSSS
Protein: Phosphotransferase (EC 2.7.1.-) (Q38C42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Glucosamine 6-phosphate N-acetyltransferase
- mannose-6-phosphate isomerase
- Glucosamine-6-phosphate isomerase
- glutamine--fructose-6-phosphate transaminase
- Fructose-bisphosphate aldolase
- fructose-bisphosphatase
- Phosphomannomutase
- glucose-6-phosphate 1-epimerase
Sequence:
MSRRLNNILEHISIQGNDGETVRAVKRDVAMAALTNQFTMSVESMRQIMTYLLYEMVEGLEGRESTVRMLPSYVYKADPKRATGVFYALDLGGTNFRVLRVACKEGAVVDSSTSAFKIPKYALEGNATDLFGFIASNVKKTMETRAPEDLNRTVPLGFTFSFPVEQTKVNRGVLIRWTKGFSTKGVQGNDVIALLQAAFGRVSLKVNVVALCNDTVGTLISHYFKDPEVQVGVIIGTGSNACYFETASAVTKDPAVAARGSALTPINMESGNFDSKYRFVLPTTKFDLDIDDASLNKGQQALEKMISGMYLGEIARRVIVHLSSINCLPAALQTALGNRGSFESRFAGMISADRMPGLQFTRSTIQKVCGVDVQSIEDLRIIRDVCRLVRGRAAQLSASFCCAPLVKTQTQGRATIAIDGSVFEKIPSFRRVLQDNINRILGPECDVRAVLAKDGSGIGAAFISAMVVNDK
Protein: Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) (P30999)
Organism: Mus musculus (Mouse)
Function: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:19267394, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:33972531}. Cytoplasm {ECO:0000269|PubMed:15138284, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:27375112}. Nucleus {ECO:0000269|PubMed:15138284, ECO:0000269|PubMed:17344476}. Cell membrane {ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:19267394}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (PubMed:17344476). Detected at cell-cell contacts (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity). CDH1 enhances cell membrane localization (By similarity). Localizes to cell-cell contacts as keratinocyte differentiation progresses (PubMed:27375112). {ECO:0000250|UniProtKB:O60716, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:27375112}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:15138284}.
Interaction partners:
- Junction plakoglobin
- Cadherin-1
- Cadherin-2
- Catenin beta-1
- Cadherin-5
- Afadin
- Catenin alpha-1
- Transcriptional regulator Kaiso
- Transforming protein RhoA
- Epidermal growth factor receptor
Sequence:
MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANSLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHNHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETTDDGTTRRTETTVKKVVKTMTTRTVQPVPMGPDGLPVDASAVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYGRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPPDQYYWAPLAQHERGSLASLDSLRKGMPPPSNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPILVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEALPTVANSTGPHAASCFGAKKGKDEWFSRGKKPTEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIAELLTSEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVVSILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIPMSNMGSNTKSLDNNYSTLNERGDHNRTLDRSGDLGDMEPLKGAPLMQKI
Protein: Protein phosphatase 1 regulatory subunit 3E (P0C7L8)
Organism: Rattus norvegicus (Rat)
Function: Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.
Interaction partners:
- Glycogen [starch] synthase, liver
- Glycogen [starch] synthase, muscle
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Protein phosphatase 1 regulatory subunit 3A
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Protein phosphatase 1 regulatory subunit 3C
- Protein phosphatase 1 regulatory subunit 3B
- Protein phosphatase 1, regulatory subunit 3D
- Ribosomal protein S6 kinase
Sequence:
MSHERPPRNDIPRNLSFIAALTERAYYRSQRPSLEEESEEEPGEGGTRPGARSRAHVPGRGRRARSAPAGGGGARTARSRSPDTRKRVRFPDALGLELAVVRRFRPGEPPRVPRHVQVQLQRDALRHFAPCPPRTRGLQDARIALEPALEPGFAARLQAQRICLERADAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSLRESPASYAGPAPAPPRADRFAFRLPAPPVGGALLFALRYRVTGREFWDNNGGRDYALLGPEHPGGAGAAEPQGWIHFI
Protein: RNA-binding protein ASD-1 (RRM domain-containing protein) (G5EEW7)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RRM domain-containing protein
- Homeobox protein ceh-39
- T-box transcription factor 18
- Signal element on autosome protein 2
- Steroid hormone receptor family member cnr14
- XO lethal protein 1
Sequence:
MTTAAEIITVEKLNDFDYKVALQQQMVAAQNGAAAAVLRPHQIGSSPEAPQSQTSGGSTEQLQQQPLPPPTQQKQQQPLTIGPVAPNDRSTSSSSTDGPRRLHVSNIPFKYREPDLTAMFEKVGPVVDVEIIFNERGSKGFGFVTMQNPDDADRARAEFNGTTIEGRRVEVNLATQRVHNKKAKPLMSVGVDAMSAQNALISQQQQIQRAALLQQQLLAQQFLVPRHQQLMMPPTSAAAISQLQALQYQQALLAAQQQQQQMQNPQFLLSLQQQQQAQAQAPPTSMAQLIQHQQQFAMDPMAQAQAQAAQAQMVTLIAFEQQRMQLQAAAAAAQGRGVPQPGRIPTSTATTGSSQNQVAAGSIGEQYLQQSMQGAVPANFHHHSQALHPAAAAAAALQRRFAPY
Protein: Epoxide hydrolase (EC 3.3.2.9) (O06266)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MGAPTERLVDTNGVRLRVVEAGEPGAPVVILAHGFPELAYSWRHQIPALADAGYHVLAPDQRGYGGSSRPEAIEAYDIHRLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADRVAAVAALSVPALPRAQVPPTQAFRSRFGENFFYILYFQEPGIADAELNGDPARTMRRMIGGLRPPGDQSAAMRMLAPGPDGFIDRLPEPAGLPAWISQEELDHYIGEFTRTGFTGGLNWYRNFDRNWETTADLAGKTISVPSLFIAGTADPVLTFTRTDRAAEVISGPYREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR
Protein: phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) (D4A5Q1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ras-related protein R-Ras
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- GTPase NRas
- GTPase HRas
- Phosphatidylinositol 3-kinase regulatory subunit beta
- RAS related 2
- Phosphoinositide 3-kinase regulatory subunit 5
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Sequence:
MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQTLWH
Protein: histidine kinase (EC 2.7.13.3) (Q1DBP2)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- DNA-binding response regulator
- histidine kinase
- Response regulator/adenylate cyclase
- histidine kinase
- DNA-binding heavy metal response regulator
- histidine kinase
- DNA-binding response regulator PhoP2
- Sensory/regulatory protein RpfC
- histidine kinase
Sequence:
MGMSAALALVLMGTFFTLFSYDLEDAIFARLVATAADGRRDDTGAIPLGMTAYVGHEGLPSWLGDALPLDTPRGEYEVFAQGRGHFHVAVRPDASAGTTRYVVLDTTALTSTTRHLRQTSGLLLASALLALLGAAGLSLVVARRLSRPLEQLVARVQSDTLAPEVDVGVTEVRALAEALRVRDARIQELLERERAFNRDASHELRTPLAVAQGAVEILELDPPADTETFGRLRQAIHHMGLLTEGILWLARSGRSDESCGLVSISREMVALYGKHRPHGDVALVIEAKEEVLAPLPGSVARVMLGNLIKNALAYTHQGRIVIHIAPEGWSISDTGVGFGQVEPGHSGFGIGLSLVERLARRFNCDVAFSAVEPHGTRVRLTWPSVEPG
Protein: A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 14 (ADAM metallopeptidase with thrombospondin type 1 motif 14) (B2RXX5)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MAWLRALLHCLLPWYCALCAAAGSQTPDLRLSGKLHDYVVTVPCSTDFQGRFLSHVVSAPAAPSPRSHLRVARSPLSLERETPRPGGPRQHFLYFNVTVFGKLLHLRLQPNRRLVAPGAPVEWQEDFRELFRQPLQQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDNSDYFIEPLERGQQEKEAGGRTHVVYRREAVQREWKEPHGDLHNEAFGLGDLPNVLDLVGDRLGDAERKRRHAKPGSYSIEVLLAVDDSVVRFHGREHTQNYVLTLMNIVDEIYHDESLGAHVNIALVRLIMVGYRQSLSLIERGNPARSLEQVCRWAHSQQRQDPSHTEHHDHVIFLTRQNFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLGMEHDGQGNGCDDETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFERTWPQPPELPGIDYSMDEQCRFDFGTGYHTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTNFGSCSRSCGGGVRSRSRSCDNPPPAYGGRPCSGSMFEYQICNSEDCPGPYEDFRAQQCAKRNSYYTHQDAKHSWLPYEPDSDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPFGCDKEVGSMKTDDKCGVCGGDNSHCRTVKGTLGKGSKQAAALKQVQIPAGARHIQIELLEKAPHRIAVKNQVTGSFIFNPKGKEASSRTFTALGLEWEHEAEDTKDSLRTNGPLPEAIAILVLPPAEGKPRGSLAYKYVIHEDLLPLIGSNNVLLEETDTYEWALKSWSPCSKACGGGIQFTKYGCRRRRDHHMVHRHLCDHKKRPKPIRRRCNQHSCPQPTWVTEEWGACSRSCGKLGLQTRGVQCLLPLSNGTHKAMPAKACLGNRPEAKKPCLRVPCPAQWRTGAWSQCSATCGEGIQQRQVVCRNTSSALGPCEGVKPDMVQICSLPACGGDLQNSTVKAEVQDPVTKTGYREPQSRPLTPEDRISTMEPCVRDRSVFCRMEVLDRYCTIPGYHRLCCESCIKKTSGPNASLALPPTFSTPGSLLPAPKATLEDVKSTRGPTSLEDHRQSQPTQLPDVADRISPVTQYPVTPQMLSPKAFPGNSPATPRRPPQDWTQTAMPTSEGQGQSREEPGHGGTSLPATSPVT
Protein: 59 protein (DNA polymerase processivity subunit) (DNA replication protein) (P88996)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Interaction partners:
Sequence:
MQTFQLDTERLCQAAKLYQHTKSDFGLNGMIQLSGSCNNMSLSVLGSIGGCAILRLELLEAARLHSSKDSSKSAIYSFRNASSLGREFTHGGELFGPKMESASLSFYGHHGVKYVEAQFVHDSSSKTVHTAAMQPITIPPSCAFDDREANGIVTLSTKTAAALVKWLKQHTKTCQSPVKVSISEILGVMVLSVGDASMTVDVTPVNVSSGKKTRGGNKASDSGTISADATVHVNGHCLIRSLIVCKVPGCTTPRVKFHACGILEVDGAPVKQGELTQVKLSVALLNVDSSTGRVLKEPVVTGASKDRGASKSEDADGSPPVPDHPKESLTSDSDSSVPGPRSTDLSSLTHTPSDRFSSDLRSGCGGQQFLKRPPPKKDREPTTKRPKLHFNHFP
Protein: Ubiquilin (G5EFF7)
Organism: Caenorhabditis elegans
Function: May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Collaborates with POST (F36D4.5) in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also acts as a regulator of DNA repair by inhibiting homologous recombination repair, thereby redirecting double-strand break repair toward non-homologous end joining (NHEJ).
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4
- UV excision repair protein RAD23
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin conjugation factor E4 ufd-2
- 26S proteasome non-ATPase regulatory subunit 2
- Polyubiquitin-A
- 26S proteasome non-ATPase regulatory subunit 13
- PCI domain-containing protein
- 26S proteasome regulatory subunit 7
- Proteasomal ubiquitin receptor ADRM1 homolog
Sequence:
MATESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADGHTVHLVIRNQARPTPAPAAATPTASSAPSSNPTPSSQPNPTNNPFAAMGGMGSPADILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFNSLLDSPGISSLMEQMMSNPSMQASMFSPEVINSIRQNMSNNPGLIDSIVGQIPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQIQEGFSTLRREAPQLLNLFQAGAMGGGAFGSDANASSAGANSANGLADLFNSMNMGGGRPSSTAAPVNPEQTYASQLEQLQSMGFSDRARNVAALTATFGDLNAAVERLLNSP
Protein: Adiponectin receptor 1 (Q3YAF8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSHKGSAVAQGNGAPSSNREADTVELAELGPLLEEKGKRAATSPAKAEEEQACPVPQEEEEEVRVLTLPLQAYHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDSLL
Protein: NifU-like protein 3, chloroplastic (AtCNfu3) (AtCnfU-IVa) (Q84RQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:12553879}.
Interaction partners:
- Fe-S cluster assembly factor HCF101, chloroplastic
- Monothiol glutaredoxin-S14, chloroplastic
- Iron-sulfur cluster assembly protein 1
- Dihydroxy-acid dehydratase, chloroplastic
- CDK5RAP1-like protein
- Threonylcarbamoyladenosine tRNA methylthiotransferase
- Cysteine desulfurase, mitochondrial
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- Iron-sulfur assembly protein IscA, chloroplastic
- Cysteine desulfurase 1, chloroplastic
Sequence:
MGSVSGQTRITTMNLSLSTAEKNPNFRSSLLNSKNAISDTLGVSSKCSTFLRGQFQRIHFSWLQHTRPLRKRTVFGHVSCVMPLTEENVERVLDEVRPSLMADGGNVALHEIDGLVVVLKLQGACGSCPSSSMTLKMGIESRLRDKIPEIMSVEQFLESETGGLELNDENIEKVLSELRPYLSGTGGGGLELVEIDGYVVKVRLTGPAAGVMTVRVALTQKLRETIPSIGAVQLLE
Protein: PDZ domain-containing protein (Q5WRR6)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
- Dystrophin-1
- Dystrobrevin-1
- Sarcoglycan complex subunit protein
- Neuroglian
- Dystroglycan-type cadherin-like domain-containing protein
- Beta-sarcoglycan
- Syntrophin-1
- Dystrophin-like protein 1
Sequence:
MSVTKSHHNLDVVHHGIVLISDGNATSRSSRLLLSKDELCIQVIDDGTAEPEEAKETFLENATRQVVIVKKPDSGFGLSIKGGSENAQNMPIVISKIFKGLPADECGELFIGDAIVEVNGISIEGQSHDEVVNMLKSSGDQVTLGVRHFTHMTPFLKPAQSLQPDGTLDQLFDGRSTRSHKAQSESRLSDSKWQQHIDGREKKWKTLTSLPLAMAYVTRYLWGTDNIRTNSFEVRAVDGRSSGIVHCEDTSALEQWISHISKHILSLNQKSIKMSNKYLHQSEQISYIGWVNEYLNDDDQEELKIRWQPRFLILKGSDVCFFDVPPLNSEDLNKCVYLYKCYDVAVKQVPNSSPRRDKRDNCFLIETPLQVPNHYLSFEAVSAFELFEQAYYRTVYNTISQMQSRTFACNFEGRASGIVFDIKQGISLYDIPTKSYIWQYRFRDLQAVADDGKLCVQLSFNDDRSLNSDRIEVKDIECEDVVTVVFNLHSFVLARIVSTDPDYLKANRYVGNAED
Protein: mRNA-binding protein (A0A1D8PFV4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RRM domain-containing protein
- Pre-mRNA-splicing factor SLU7
- U1 small nuclear ribonucleoprotein component SNU71
- Pre-mRNA-splicing factor CEF1
- Mtr10p
- Nuclear cap-binding protein subunit 2
- Protein-arginine omega-N methyltransferase
- Nuclear cap-binding protein complex subunit 1
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
Sequence:
MDGPVEVTKQLFVRPLRNDVTREEVQDHFSRAAPVVEVRLMEGYAFVTFENEDDAKQALELLNDAEFNGEKLQIEFAKERREDTRGKYRLLITNLAEGTAWQDIKDFVREKTDSQPSYVKVFTNFDNGETTCSMQFQSREDLDRAIPLLDKAVFRDITIGAEEDTSPYIPPPPRGRGGFRGRGRGGFDRGFRGGRGGYDRYDRGGFRGGRGGFDRGFDRGGFRGGRGGYDRGGFRGGRGGFDRGGFRGGRGGFRGGRGGYDRGGYDRDNFNDRGGSYDRERSPTRF