wanglab/gogpt-training-data huggingface dataset:
Protein: RNA helicase (EC 3.6.4.13) (F1RX16)
Organism: Sus scrofa (Pig)
Interaction partners:
- TANK binding kinase TBK1.
- RNA helicase
- [histone H3]-trimethyl-L-lysine
- ATP-dependent RNA helicase A
- Eukaryotic translation initiation factor 3 subunit B
Sequence:
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSNKDKDAYSSFGSRNDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRGGFGKYERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNANITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
Protein: Tubulin beta-5 chain (Beta-5-tubulin) (P29513)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin alpha-2 chain
- Tubulin alpha-6 chain
- Tubulin alpha-5 chain
- Tubulin alpha-1 chain
- Gamma-tubulin complex component 4
- Mitotic spindle checkpoint protein MAD2
- Tubulin beta-4 chain
- Tubulin beta-9 chain
- Tubulin beta-8 chain
- Tubulin alpha-4 chain
Sequence:
MREILHIQGGQCGNQIGSKFWEVICDEHGIDSTGRYSGDTADLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSIRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDAVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLSTPSFGDLNHLISATMSGVTCSLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYISLTVPELTQQMWDSKNMMCAADPRHGRYLTASAIFRGQMSTKEVDEQILNIQNKNSSYFVEWIPNNVKSSVCDIPPKGLKMAATFVGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDATADEEGEYDVEEEEEGDYET
Protein: Rho GTPase activating protein 1 (D4A6C5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cell division control protein 42 homolog
- Transforming protein RhoA
- Ras homolog family member C.
- BCL2 interacting protein 2
- Rho-related GTP-binding protein RhoB
- RSA-14-44 protein.
- Ras homolog family member D
Sequence:
MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHIVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV
Protein: Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (Cytoplasm to vacuole targeting protein 2) (P38862)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.
Subcellular location: Cytoplasm. Preautophagosomal structure.
Interaction partners:
- Ubiquitin-like protein ATG12
- Autophagy-related protein 8
- Putative lipase ATG15
- Autophagy-related protein 3
- Ubiquitin-like-conjugating enzyme ATG10
- Cysteine protease ATG4
- Autophagy protein 5
- Autophagy protein 16
- Autophagy-related protein 18
- Autophagy-related protein 9
Sequence:
MSSERVLSYAPAFKSFLDTSFFQELSRLKLDVLKLDSTCQPLTVNLDLHNIPKSADQVPLFLTNRSFEKHNNKRTNEVPLQGSIFNFNVLDEFKNLDKQLFLHQRALECWEDGIKDINKCVSFVIISFADLKKYRFYYWLGVPCFQRPSSTVLHVRPEPSLKGLFSKCQKWFDVNYSKWVCILDADDEIVNYDKCIIRKTKVLAIRDTSTMENVPSALTKNFLSVLQYDVPDLIDFKLLIIRQNEGSFALNATFASIDPQSSSSNPDMKVSGWERNVQGKLAPRVVDLSSLLDPLKIADQSVDLNLKLMKWRILPDLNLDIIKNTKVLLLGAGTLGCYVSRALIAWGVRKITFVDNGTVSYSNPVRQALYNFEDCGKPKAELAAASLKRIFPLMDATGVKLSIPMIGHKLVNEEAQHKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNIENKTVINAALGFDSYLVMRHGNRDEQSSKQLGCYFCHDVVAPTDSLTDRTLDQMCTVTRPGVAMMASSLAVELMTSLLQTKYSGSETTVLGDIPHQIRGFLHNFSILKLETPAYEHCPACSPKVIEAFTDLGWEFVKKALEHPLYLEEISGLSVIKQEVERLGNDVFEWEDDESDEIA
Protein: Glucose-6-phosphate 1-dehydrogenase 1 (G6PD 1) (EC 1.1.1.49) (P9WN71)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Interaction partners:
- 6-phosphogluconolactonase
- Probable 6-phosphogluconate dehydrogenase,decarboxylating Gnd2
- Glucose-6-phosphate isomerase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Glyceraldehyde-3-phosphate dehydrogenase
- Glucose-6-phosphate 1-dehydrogenase 2
- Probable phosphoglucomutase PgmA
- Pyruvate kinase
- Possible sugar kinase
- Triosephosphate isomerase
Sequence:
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
Protein: Polychaetoid, isoform C (Q8INQ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKFPDYVPNNMLVGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPPTGQSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRPPVQSGGSSGSGGTTPWENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQPTYGGSNGNYGQAPPPQSYPQANGYNGNGHHYNGGSGTGPYIAPHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAFELYRKPQIGATAGHHHNMR
Protein: Uncharacterized protein (Q5A9D8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Protein SDA1
- Ribosome biosynthesis protein
- Utp5p
Sequence:
MLHIVVIDMLPGRVRKKREFYRNFHKLIIISIFFSEHSSRFQTSKPHPMEAKNLHTWLPFTDNDWILKIIQLSEKEFIASTSNGSLIGYSISNLSSTPTIKIEKAHESSINDIVKIDNDSIASCSSDGIKIWNLRSKSAIVTLTNAKKSNFLSLAYKNNLLAAGTELVGVDAELHIWDIRNTDNVVRSFVDSHHDDITALEFHPTLTNYLMSGSTDGYVNIYNLIETEEDEALHQVINFASVHSCHFITESRISILTHMETLMIHDLNDTNYEELVEPKFKDFGDLRKEWPSNEYVIDISPTGFAAYGSNSESSLSLLPFDPESESFDLSKLISFPKAHGEEVVRDFVLIPNSKMALSCGEDGRIKLWELPFQLKSFVLGSEEKETDITMTEGDVQSEKKSKKDKKDKKKDKKKDKKKHKKDVRFKPY
Protein: Vacuolar protein sorting-associated protein 1 (G5EB49)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- BAR domain protein
- Clathrin heavy chain
- UBA/TS-N domain protein
- SlaB
- Mitochondrial fission 1 protein
Sequence:
MASPTTGYSINVNDPSLISLVNKLQDVFSTVGVQNPIDLPQIAVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLINKPSQTNGVKDEQLETTDKEANLDEYGEFLHIPGQKFYDFNKIRDEIVRETETKVGRNAGISAAPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPKDIERQIRDMVLKYISKPNAIVLAVTAANQDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDEGTDVVDILAGRIIPLRLGYVPVVNRGQRDIENKRPISYALEHEKNFFESHKAYRNKASYCGTPYLARKLNLILMMHIKQTLPDIKSRISSSLQKYSSELAQLGDSMLGNSANIILNIITEFSNEYRTVLEGNNQELSSVELSGGARISFVFHELYSNGIKAVDPFDQVKDIDIRTILFNSSGSSPALFIGTTAFELIVKQQIARLEDPSLKCISLVYDELVRILGQLLNKQLFRRYPMLKEKFHAVVIAFFKKAMEPTNKLVRDLIAMETTYINTAHPDFLNGHRAMAIVNERHAAAKPTQVDPKTGKPLPPRANSPSVEATTPDTNSSSGFFGSFWASKNKKKMAAMEAPPPNLKASAALSERESTEVEVIKLLITSYFNIVKRTMIDMVPKAIMYTLVQYSKEGMQRELLENMYRNAELDDLLKESDYTIRRRKECQQMVESLSRASEIVSQVQ
Protein: Hypothetical HAD-superfamily hydrolase (Eurofung) (Q5B1L6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Phosphatidate cytidylyltransferase
- phosphoserine phosphatase
- Phosphatidate cytidylyltransferase, putative
- Flavoprotein, putative
- Methylenetetrahydrofolate dehydrogenase [NAD
- Epoxide hydrolase, putative
- Epoxide hydrolase, putative
- Epoxide hydrolase, putative
Sequence:
MPRFEDSDFGVEGSPSAPPARGSTLDTRSPGDRGSMGGQLPIPNDANNIVEVPATRSSISDAASFMHNLSLAPSSRDRRGSRNSFGTSLPIPRSPRVSRLSSVVPADVSRDILASQIQDMSKEKVAAAKNMAFAFDIDGVLAHGNHPIEEAKQALKMLNGDNELGIKIPYILLTNGGGKTEAARCQQLSEVLDCPISTDQFIQSHTPMQALSDYYETVLVCGGEGTKIREVAENYGFKNVILPKDIQAWDPTVSPWGHFSEQDRAEAKPRDFSKIKFDAILVFADSRDYQTDFQIIMDLLLSEDGRLLTRAKDLTQGRIPIYFSQGDLIMPTDHKGPTRLTQGLYRISIEAQYKALTGLDLERVVYGKPEEATYKYADEVLRSWMEQIHNENTLPENIYMVGDNPASDICGGNMHGWNTCLVRTGVFQGGDNDETNPANFGVFPNVLEAVKAAVRKELGQEFKLKWNPKVNPVLHGNNASAIE
Protein: Homeobox protein knotted-1-like 3 (Protein KNAT3) (P48000)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription repressor OFP5
- BEL1-like homeodomain protein 1
- Transcription repressor OFP4
- Transcription repressor OFP1
- Protein KNATM
- Transcription repressor OFP2
- Gamma interferon responsive lysosomal thiol
- At4g32030
- AT3g18370/MYF24_8
- Transcription repressor OFP8
Sequence:
MAFHHNHLSQDLSFNHFTDQHQPPPPQPPPPPPQQQQHFQEAPPPNWLNTALLRSSDNNNNFLNLHTATANTTTASSSDSPSSAAAAAAANQWLSRSSSFLQRNNNNNASIVGDGIDDVTGGADTMIQGEMKTGGGENKNDGGGATAADGVVSWQNARHKAEILSHPLYEQLLSAHVACLRIATPVDQLPRIDAQLAQSQHVVAKYSALGAAAQGLVGDDKELDQFMTHYVLLLCSFKEQLQQHVRVHAMEAVMACWEIEQSLQSLTGVSPGEGMGATMSDDEDEQVESDANMFDGGLDVLGFGPLIPTESERSLMERVRQELKHELKQGYKEKIVDIREEILRKRRAGKLPGDTTSVLKAWWQSHSKWPYPTEEDKARLVQETGLQLKQINNWFINQRKRNWHSNPSSSTVLKNKRKSNAGDNSGRERFA
Protein: Cornetto, isoform D (M9PHM1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSATLFEMDSQTEEQQQTVCLEEQQLVVGMTSLELSESVVTPGNCDGSDSGLDVASCCHSRITLQRGLSSTSGGYTSSNGLEEIYDSCELKVTTVAQTPSETGSEKTSPPRRTGSVKKKVAMFEPEPTGTPAKDQLRGRVANLKRAESLPRNSAAPGTPGTPSTHRDKARLSTSSFRVPSTTGTPSSSRLARPQKPDTLPNALNRAQSVQRLTQVQRTPSLSRARTPGTPSDDGRWPANRGAARRGMSVTPEVTTNRMRGSPAPGGTLPRRRKQQSVEDLTGGRLSRSNSISRAAIVDARMTSSVMVVPTSRRSLAPAAAKVNSLRRPQPATPRTRIYHETAVQTALTSEDLEQVLGGGLLQTRAVDAVEQRNQSTQAEPDQREFELEQLRHEVRQLSGKLQREREEKLAMQQELHLNTERVMGMLELARVVSASAGTPTSEDSGDGSGHDSLLMLESQIQISGHELFERQQEIGQLRSMCRALQLEMRRSLATQQLLLQEKAAIEQESSELQDFLQHEKAAQCDALRDLEADYQAVKLQLANREEEAKVLRDECRHLVRLNEQRRQENRLLQTKFTALENKSRELIHQQNASVAGASTALSGLHSRLDGLVEQLVYSYSISEQDLEDIRFQAETEHVQNGQRPNGLDLPICPAASGDAIHTLVLASDGSLSPQRNQSFIAAVIGAIRQATTHSGKRLSLRQAGKKNGVGLGSAQAVSAGTQGQEPQGNGDDSDSTEMLDSETEPCLLMMDNVLEDVVHHDSHSHNMVSSCTGMISQIELPTELISQCSHQNNINGGAGGDDSLQQLSQAITNRQQMELHMHKMNGMPMNPRDQCNTEELSCHDSLAELTELPSLMEYSTAQAVVDQVIEVDTLVTKLLKVLRLVQLDNDNCIQQLIVDKNKLQQHKEDMLEKLKDLEDVNLKLQDELMDATQELMIKGSDLSGAKAEMQRHRNEIDRLNEDICTLSTLCSSYKKLSPTTEFPPMRLLSPNQDSDQGDVLGILNLLKMWQAGGQLKDPRVRGYLEIANGTQHNNNVERLRIYANQLEHVSRVLDNALPTELHAPLQQLRQDIEVVRTNANWTQLLESNETDHNANGDVATP
Protein: Kazachoc, isoform A (Q9W1G6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPDRFQVTKADEDTALDYNQDESASGKLLGDIHDETLGENYGSYDDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS
Protein: Protein hairy (P14003)
Organism: Drosophila melanogaster (Fruit fly)
Function: Pair-rule protein that regulates embryonic segmentation and adult bristle patterning. Transcriptional repressor of genes that require a bHLH protein for their transcription (e.g. ftz).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Protein groucho
- Achaete-scute complex protein T5
- C-terminal-binding protein
Sequence:
MVTGVTAANMTNVLGTAVVPAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRFPGIEPAQRRRLLQHLSNCINGVKTELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPPSPANSSYEPMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW
Protein: N-acetyltransferase domain-containing protein (A0A178W1H3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEMDSEETNPIMSSSPPGRISLRPMTLSDVDDYMVWATDPKVARFCTWEPCTSRDEAIKYITDRVLTHPWLRAICLEDDRPIGYILIMAVDNIRKEIGYVLARKYWGKGFATEAVRLVTAEVFEEFPEIERLEALVDVDNVGSQRVLEKVGFTREGVMRKFICIKGSVRDTVMFSFLSTDTLK
Protein: Four and a half LIM domains 1 (Q5JXI0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSF
Protein: Protein argonaute-1 (Argonaute1) (mAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Piwi/argonaute family protein meIF2C1) (Q8CJG1)
Organism: Mus musculus (Mouse)
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
Subcellular location: Cytoplasm, P-body {ECO:0000250}.
Interaction partners:
- Endoribonuclease Dicer
- Trinucleotide repeat-containing gene 6A protein
- Protein argonaute-2
- Protein argonaute-4
- Protein argonaute-3
- RISC-loading complex subunit TARBP2
- Ribonuclease 3
- Fragile X messenger ribonucleoprotein 1
- Trinucleotide repeat-containing gene 6C protein
- Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Sequence:
MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA
Protein: Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) (P10606)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Peripheral membrane protein {ECO:0000269|PubMed:30030519}; Matrix side {ECO:0000269|PubMed:30030519}.
Interaction partners:
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome b-c1 complex subunit 10
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Sequence:
MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLDPYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHYKLVPQQLAH
Protein: Growth hormone receptor (Somatotropin receptor) (F1MQ39)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MWKSSVHVLSQGEHPPEVECPTGMDLWQLLLTLAVAGSSDAFSGSEATPAFLVRASQSLQILYPVLETNSSGNPKFTKCRSPELETFSCHWTDGANHSLQSPGSVQMFYIRRDIQEWKECPDYVSAGENSCYFNSSYTSVWTPYCIKLTSNGGIVDHKCFSVEDIVQPDPPVGLNWTLLNISLTEIHADILVKWEPPPNTDVKMGWIILEYELHYKELNETQWKMMDPLMVTSVPMYSLRLDKEYEVRVRTRQRNTEKYGKFSEVLLITFPQMNPSACEEDFQFPWFLIIIFGILGLAVTLFLLIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDNYKHEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHEKSLNIFGAKDDDSGRTSCYEPDILEADFHVSDMCDGTSEVAQPQRLKGEADISCLDQKNQNNSPSNDAAPASQQPSVILVEENKPRPLLIGGTESTHQAVHTQLSNPSSLANIDFYAQVSDITPAGNVVLSPGQKNKTGNPQCDTHPEVVTPCQANFIVDNAYFCEVDAKKYIALAPHVEAESHVEPSFNQEDIYTTTESLTTTAGRSGTAEHVPSSEIPVPDYTSIHIVQSPQGLVLNATALPLPDKEFLSSCGYVSTDQLNKIMP
Protein: Botulinum neurotoxin type F (D2KHQ9)
Organism: Clostridium botulinum
Interaction partners:
Sequence:
MPVEINSFNYDDLVNDNTILYIRPPYYERSNTYFKAFNIMENVWIIPERYRLGIEASKFDPPDSLKAGSDGYFDPNYLSTNTEKNRYLQIMIKLFKRINSNEAGKILLNQIKDAIPYLGNSYTAEDQFTTNNRTISFNVRLANGTIEQEMANLIIWGPGPDLTTNRTGGTTYTPAQSLEAIPYKEGFGSIMTIEFSPEYATAFNDISLTSHAPSLFIKDPALILMHELIHVLHGLYGTYTTGFKIKPNITEPYMEVTKPITSGEFLTFGGNDVNKIPQLIQSQLRSKVLDDYEKIASRLNKVNRATAEINIDKFKYSYQLKYQFVKDSNGVYSVDLDKFNKLYDKIYSFTEFNLAHEFKIKTRNSYLAKNFGPFYLPNLLDNSIYNEADGFNIGDLSVNYKGQVIGSDIDSIKKLEGQGVVSRVVRLCLNSSFKKNTKKPLCITVNNGDLFFIASEDSYGEDTINTPKEIDDTTTLVPSFKNILDKVILDFNKQVTPQIPNRRIRTDIQEDNYIPEYDSNGTSEIEEYNVVDLNAFFYLHAQKVPEGETNISLTSSIDTALSEESKVYTFFSSEFIDTINEPVNAALFIDWISKVIRDFTTEATQKSTVDKIADISLIVPYVGLALNIVNETEKGNFKEAFELLGAGILLEFVPELAIPVILVFTIKSYIDSYENKNKIIKAINNSLIEREAKWKEIYSWIVSNWLTRINTQFNKRKEQMYQALQNQVDAIKTAIEYKYNNYTSDEKNRLESEYNINNIEEELNKKVSLAMKNIERFITESSISYLMKLINEAEVGKLKEYDKRVKRHLLEYIFDYRLILGEQGGELIDLVTSTLNTSIPFELSSYTNDKILIIYFNRLYKKIKDSSILDMRYENNKFIDISGYGSNISINGNVYIYSTNRNQFGIYDDRLSEVNIAQNNDIIYNSRYQNFSISFWVRIPKHYRPMNHNREYTIINCMGNNNSGWKISLRTTGDCEIIWTLQDTSGNKKKLIFRYSQLGGISDYINKWIFVTITNNRLGNSRIYINGNLIVEKSISNLGDIHVSDNILFKIVGCDDKMYVGIRYFKVFNTELDKTEIEILYSNEPDPSILKDYWGNYLLYNKKYYLLNLLRNDKYITRNSDILNISHQRGVTKDLFIFSNYKLYEGVEVIIRKNGPIDISNTDNFVRKNDLAYINVVDHGVEYRLYADISITKPEKIIKLIRRSNPDDSLGQIIVMDSIGNNCTMNFQNNNGGNIGLLGFHSDNLVASSWYYNNIRRNTSSNGCFWSFISKEHGWQE
Protein: Very Early Transcript (G5EEK5)
Organism: Caenorhabditis elegans
Interaction partners:
- Very Early Transcript
- Protein sepa-1
- F-box domain-containing protein
- F-box C protein
- DUF38 domain-containing protein
- Uncharacterized protein
- Very Early Transcript
- SKN-1 Dependent Zygotic transcript
- BTB domain-containing protein
- SKN-1 Dependent Zygotic transcript
Sequence:
MSSNSALELKSALSQLNRERSEMVKDLEKAQKDYVAARNMHKSTGSQNHLEVVNTCWKNVQAAQKAHQSKVEEFHMVRRSFADAVRESPESCSIKNRESNPSSTNDQDLAAKKAVLDAEFREEAIRDGVFIPTQRYNSTLPPPLVRNEYVAEPKKSTADEDFEKRMVELQRQASKYAKIGDSAVLKDRSTGLTAATIQLFAEYFPKRRELSNARKDFMTVLNLHASTGFLKYCEAVNASRKHLEAVEEAYRKTTNELCKDLNEYPMESDKDVKERASKYAEICRLKESEDQLLDLLKPASSELIPLFNEIVNLSGIRTKKTPTQTTEASQIAPESISTSNVDPATQLDPETTQTSPLTSAPVSWFNSESSDINQDITSYPDLVHHPGVDSEKQMVEFHRQALRLYELQTSQTLASCFDSESQEVNSLLNNAFVEASEITEENISTTNVESTSQSEPTEVTPETTQESAPTSAPVVWSEAPGYGARQECNPRMCTNRQHSSPIRIRHCTSRNVTTYSVYCWKRPSHVYTYNHQEEKFEQHKCLACVPRVQENHLFPTCAVWNEKISNFVIFMDNMVTKQKDEQYMFSFKTGGFEQVNYPEVQPAQGPKNTDFVAAVNGDGDDQVIIQKSRFGVKKLEFRYGKYVKIPSVEVRTLLMKELEGVEMVQEPSSTLPLSTIRWCPTYSQSALYIFSSRLGHYLKYAFNPSTQQFEQLNCSGCPLNVEEWHLCPLYAEYADSIKTYVIHVFNDFTKEIEKYMYCVTGKCFYQVTCPEIVYDSSKAHSSTVLFTVSAPNHPFTIFMKDVNGRIKKEQLNGLHNGYMELPSAKVYTLYAMRCNNSAGTTGI
Protein: Enoyl-[acyl-carrier-protein] reductase [NADH] (ENR) (Enoyl-ACP reductase) (EC 1.3.1.9) (FAS-II enoyl-ACP reductase) (NADH-dependent 2-trans-enoyl-ACP reductase) (P9WGR1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the double bond of 2-trans-enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway. Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates. The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids.
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] reductase MabA
- Probable fatty acid synthase Fas
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Malonyl CoA-acyl carrier protein transacylase
- Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III
- DNA gyrase subunit A
- Nicotinamidase/pyrazinamidase
- DNA gyrase subunit B
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL