wanglab/gogpt-training-data huggingface dataset:
Protein: SR-CI (Q5ELU0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSLDLDNGSINYRPRNIVRFRCNRGYTLQGTVMQTCDRDGRLRGEKPFCASRGCAKPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVQLMTGSECGTNGFTTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSMSASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSLPPTVTSISTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTFTTSTTSTRPTTTTTINVFTTKKTTIMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLAIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLRKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV) (Q9BYZ8)
Organism: Homo sapiens (Human)
Function: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
Subcellular location: Secreted {ECO:0000269|PubMed:12819006}.
Interaction partners:
- Serine protease inhibitor Kazal-type 4
Sequence:
MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP
Protein: AE binding protein 2 (H0YH08)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
LARPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRSDKPFTFCHDCEASSAM
Protein: Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) (P11169)
Organism: Homo sapiens (Human)
Function: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9477959, ECO:0000305|PubMed:26176916}; Multi-pass membrane protein {ECO:0000269|PubMed:26176916}. Perikaryon {ECO:0000250|UniProtKB:Q07647}. Cell projection {ECO:0000250|UniProtKB:Q07647}. Note=Localized to densely spaced patches along neuronal processes. {ECO:0000250|UniProtKB:Q07647}.
Interaction partners:
- Solute carrier family 2, facilitated glucose transporter member 14
- Cyclic AMP-responsive element-binding protein 1
- Methyl-CpG-binding protein 2
- Hexokinase-1
- Hypoxia-inducible factor 1-alpha
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
- L-lactate dehydrogenase A chain
- Monocarboxylate transporter 4
- Hexokinase-2
Sequence:
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
Protein: KAT8 regulatory NSL complex subunit 1 (A0A1W2PRB5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGKRALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGAPIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCVAARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAMLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR
Protein: Cyclin-dependent kinases regulatory subunit 2 (CKS-2) (P33552)
Organism: Homo sapiens (Human)
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Interaction partners:
- G2/mitotic-specific cyclin-B1
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 2
- Cyclin-dependent kinases regulatory subunit 1
- Cyclin-A2
- S-phase kinase-associated protein 2
- G2/mitotic-specific cyclin-B2
- Cell division cycle protein 20 homolog
- S-phase kinase-associated protein 1
- Cyclin-dependent kinase 3
Sequence:
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK
Protein: Prominin, isoform C (Q8MLN9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDQRNLTLPTPAATTIMSSSSAAMSAGFASLGGPTTSALTGSTIALATTTTTAPPTTTPATFFTYSIPGMDIAPGPFIFTYVSEFLSLITPEELPLDSIRDVLHKNTSLLDFASNAIKIESGFIALMSVFAILALVPLIATCAWCCGRRSTQEEVDHIRNAPCHIRDESLEESLRCRKSAGLVTLWVVFILLTLSDFSIFYANSRLSAGIEMTPEMVKSAVHDVEVFLKDTHLQIKQKLDNGFHVSVERVVKDLEDVDVLLGEPIQAEISAHTGLELAYDSLTTLSLANAELIYRVLMLQETVGRALKLSQEAAARMEELQIQLSVLQRQCTYRDRPLCDTLRIRSFEENGVVDALKTLQEDQSIFRMRYLGEIEFGATVKNLTSEVGVSRSIFSNFPQQVKHDTAYERNYTLEQLASIRHRTTANAQQLTSTVNGLLRRLEDTWSSLQPAYNELKEWADAYWSVGWIAGTVIVWVMLFMLMSYCCFLCESNAKSGVVFFIAVMLICLASICLTIFGVFSLAVGGNAEVFVCRSLYDEDYNMLGKLLDKPGYAYAREPQTGIIGELLRPVGVNRSVVNVGLGQALRGCEQNQASYNVFQLDAFVNTSKIADLRQFPKVSTAIDAISVSGRTLLSLTQSVQNILDNMLQTSSFNLTTYRSSVGAPTPEKDLATFIDQMQRVALQIQDVATSSRMTTLGSRSKRLQASILQPLENLQNEILYHLTALELQRDPWAKQVNQTLNHLKSIQSYLENKAGEICHNMTRDYRDRLKAYLTTSKATMESQLGDTTTKCRPFYDTFDASRTFLCRNMVDFINGLTFFIFLTLLLWAIGTPVGLNLITVQTRLNVMQAAQARSKGRHRRSDRSPEHEQRSGSRGRKKQRTSSSATSGRSGKRDQSRERSTSSTARPKPPL
Protein: UDP-glycosyltransferase 76E2 (EC 2.4.1.-) (Q9LTH2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses low quercetin 3-O-glucosyltransferase and 7-O-glucosyltransferase activities in vitro.
Interaction partners:
Sequence:
MEEKQVKETRIVLVPVPAQGHVTPMMQLGKALHSKGFSITVVLTQSNRVSSSKDFSDFHFLTIPGSLTESDLQNLGPQKFVLKLNQICEASFKQCIGQLLHEQCNNDIACVVYDEYMYFSHAAVKEFQLPSVVFSTTSATAFVCRSVLSRVNAESFLIDMKDPETQDKVFPGLHPLRYKDLPTSVFGPIESTLKVYSETVNTRTASAVIINSASCLESSSLARLQQQLQVPVYPIGPLHITASAPSSLLEEDRSCVEWLNKQKSNSVIYISLGSLALMDTKDMLEMAWGLSNSNQPFLWVVRPGSIPGSEWTESLPEEFNRLVSERGYIVKWAPQMEVLRHPAVGGFWSHCGWNSTVESIGEGVPMICRPFTGDQKVNARYLERVWRIGVQLEGDLDKETVERAVEWLLVDEEGAEMRKRAIDLKEKIETSVRSGGSSCSSLDDFVNSM
Protein: Probable galacturonosyltransferase 5 (EC 2.4.1.-) (Like glycosyl transferase 5) (Q8RXE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in pectin and/or xylans biosynthesis in cell walls.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Alkaline-phosphatase-like family protein
- Granule-bound starch synthase 1, chloroplastic/amyloplastic
- Glycine-rich protein
- Glycine-rich protein like
- Probable methyltransferase PMT14
- Pectinesterase 4
Sequence:
MNQVRRWQRILILSLLLLSVLAPIVFVSNRLKSITSVDRGEFIEELSDITDKTEDELRLTAIEQDEEGLKEPKRILQDRDFNSVVLSNSSDKSNDTVQSNEGDQKNFLSEVDKGNNHKPKEEQAVSQKTTVSSNAEVKISARDIQLNHKTEFRPPSSKSEKNTRVQLERATDERVKEIRDKIIQAKAYLNLALPGNNSQIVKELRVRTKELERATGDTTKDKYLPKSSPNRLKAMEVALYKVSRAFHNCPAIATKLQAMTYKTEEQARAQKKQAAYLMQLAARTTPKGLHCLSMRLTTEYFTLDHEKRQLLQQSYNDPDLYHYVVFSDNVLASSVVVNSTISSSKEPDKIVFHVVTDSLNYPAISMWFLLNPSGRASIQILNIDEMNVLPLYHAELLMKQNSSDPRIISALNHARFYLPDIFPGLNKIVLFDHDVVVQRDLTRLWSLDMTGKVVGAVETCLEGDPSYRSMDSFINFSDAWVSQKFDPKACTWAFGMNLFDLEEWRRQELTSVYLKYFDLGVKGHLWKAGGLPVGWLTFFGQTFPLEKRWNVGGLGHESGLRASDIEQAAVIHYDGIMKPWLDIGIDKYKRYWNIHVPYHHPHLQRCNIHD
Protein: Autophagy-related protein 40 (Q99325)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a receptor for reticulophagy. Directs autophagic sequestration of folded tubules/sheets derived from the cortical endoplasmic reticulum (cER) and the cytoplasmic endoplasmic reticulum (cytoER) into autophagosomes. Is not required for the cytoplasm-to-vacuole targeting pathway, mitophagy, pexophagy, and non-selective autophagy.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26040717}; Single-pass membrane protein {ECO:0000255}. Preautophagosomal structure membrane {ECO:0000269|PubMed:26040717}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Autophagy-related protein 8
- Autophagy-related protein 39
- Autophagy-related protein 11
- Autophagy-related protein 34
- Autophagy-related protein 36
- Autophagy-related protein 19
- Translocation protein SEC62
- Autophagy-related protein 32
- Reticulon-like protein 1
- Ubiquitin-binding protein CUE5
Sequence:
MFNLILWPLFLLTSVAIPLQLTLEVVYLTSSVDFSKASAAKTATSLGQSPVVITIYKSLLKYWSLYEFIHFIYLYTPIDAFLNFLPFTSLLMSFGSICLTRELVYDFIAFMESQNKLTGFLNKITEPNFNSYLLFSSIYNIWFADDTNDKFLFGKLTQILISVTKRYEFPRTFYLAKVSDFLQNLILTRLRPFVTEQPQGDKNRYQNGDRESTKNGAAYQKSSQQSSSFEQNFTSTEFPNDYDFMEDILDETTELD
Protein: Homeobox protein CDX-1 (Caudal-type homeobox protein 1) (P18111)
Organism: Mus musculus (Mouse)
Function: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MYVGYVLDKDSPVYPGPARPSSLGLGPPTYAPPGPAPAPPQYPDFAGYTHVEPAPAPPPTWAAPFPAPKDDWAAAYGPGPTASAASPAPLAFGPPPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSVAAAGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPLPPTQLPLPLDGTPTPSGPPLGSLCPTNAGLLGTPSPVPVKEEFLP
Protein: Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST-1) (EC 2.8.2.-) (O60243)
Organism: Homo sapiens (Human)
Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Heparan sulfate 2-O-sulfotransferase 1
- D-glucuronyl C5-epimerase
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Heparan sulfate glucosamine 3-O-sulfotransferase 1
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
- NMDA receptor synaptonuclear signaling and neuronal migration factor
- Anosmin-1
- Prokineticin receptor 2
Sequence:
MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW
Protein: Protein vein (Epidermal growth factor-like protein) (Protein defective dorsal discs) (Q94918)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ligand for the EGF receptor. Seems to play a role in the global proliferation of wing disc cells and the larval patterning. Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence. Required for the development of interveins cells.
Subcellular location: Secreted.
Interaction partners:
- Epidermal growth factor receptor
- DShc protein
- Protein spitz
- Protein daughter of sevenless
- Ras-like protein 1
- Tyrosine-protein kinase Src64B
- Tyrosine-protein kinase
- E3 ubiquitin-protein ligase NRDP1
- Pi3K21B, isoform B
- Protein MEMO1
Sequence:
MYAQHLRKWSLKTKKQLMPLILLIISYMLLLNTCVLSSSATTQQQQQQQQQQQHLPRLWEGSAEESSYYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLNSNSLSSRSNVKLKPATVFDAGSSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAASSKMRRHIQPSQLPHQPESRAQLPSNYSSRPAVRSYLIESYEMPESMLEDRSPEQAARSRRDGSNTNGSRQQQRTGHRQQLQQDKRDHRRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQRKHQRYNRYCSARDPAQLAFAAPTVFQGVFKSMSADRRVNFSATMKVEKVYKQQHDLQLPTLVRLQFALSNSSGECDIYRERLMPRGMLRSGNDLQQASDISYMMFVQQTNPGNFTILGQPMRVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEVSGQPPPKVTWFKDEKSINRKRNIYQFKHHKRRSELIVRSFNSSSDAGRYECRAKNKASKAIAKRRIMIKASPVHFPTDRSASGIPCNFDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCENKWPDSRYFVAIYGQIHTLNNDY
Protein: Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Q62070)
Organism: Mus musculus (Mouse)
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Interaction partners:
- Serine/threonine-protein kinase pim-1
- Papillary Renal Cell carcinoma
Sequence:
MARATNLNAAPSAGASGPPDSLPSTLAPPSPGSPAALPRASTPCGLSGFSGLNIRSTSSMLTKPLQGHPSPPVTPTQPPGGKDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEKPINSSKGSPTPLPWSLLP
Protein: G patch domain-containing protein 4 (Q3TFK5)
Organism: Mus musculus (Mouse)
Interaction partners:
- WD repeat-containing protein 46
- Bystin
- Nucleolar MIF4G domain-containing protein 1
- Protein MAK16 homolog
- DNA-directed RNA polymerase I subunit RPA34
- Surfeit locus protein 6
- Ribonuclease P protein subunit p38
Sequence:
MSVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRRENGITQALKVTLKQDNHGVGHDPAKEFTDHWWSDLFNKTAASLVVDSGKDGVQIRRLSKETTQRSHPKPSLLYQKFVKTATLTSGEEKPDRDLGNCSDVDNHEPTPPKILTDEMLLKACEGRTAHKAARIGITMKAKLARLEAQEQAFLAQLKGSKALGTSQPLTDSEPSQKKKKKRKQKEGEEAATTEKSLGDELLGHTDRSFRDSRKKKKRQKAERQGTAIGSEEEEAAGESGPRELSTEQSDQPSRKKKKRRKQRHEEDGEMGVCDEGGRDVTSRPKAVNSGGDKDPRRSSKKRGTCGEDLDTQEEEGKDDLTKGERKVRRKDKRKRQQCCEEDLDVSSKDDGGTWVAEDAGERSRQYPKERAKKKKRKRDRGSEVDLS
Protein: Phospholipid scramblase (Q18242)
Organism: Caenorhabditis elegans
Interaction partners:
- C2 domain-containing protein
Sequence:
MLLTCRFTAATSRLSACTRSFSIDFSHEKPAPHQLEHVTTRLTETVPLMFRRRMDYTFYRKDVVCDDQIFSVEKRGIEQLMSHFGMIGTLGQVFLPHVEMEMLSVAPVIDEGTVRCRWRVKYVSFTRIIMNPRLLRFDYRMQNLSWFDGYSVLTVDGNGEVYKVTLQKMQQDEQKSLLTSTTEKLKEKLAPSAANN
Protein: Multidrug resistance regulator 1 (Q5A4G2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSIATTPIETPKSPKSTEPQVRKRKKVSTVCTNCRKRKIRCDRQHPCNNCIKSKKHNACVYDDGQVSPANFSTNGSSHGNTVPESRPYEESARIPIRFDAEAPRKKSKPNTPNNERKNSKKSPDNTVANNQQTASENEVTITLSELNMLKQRLQNIEANINAQSNPQSNPSYVPQTPAYPTQPNILPPPVSFNSWSPKQSNERVMFSPQQRLTTNYNVSHTRGQSPSIQLPPLSFKDTPRASIDSAPLYSEMSPPRSDLIASSLTSPESIQMSVSGDVVGVNPYLNETETINFYDGYTSICVRDFRRVNHGPFAWSSLMRKDKALSSLWNHILKKKEKKNVASQTFVFGQDVHEISQENTQLVASESNESETKFKKKTLETFGFNDVVPYDILKKKLQTQINKTTSPLGLTLYEEQVNMELQLVDRIHQQLPKKKVLWKLIDRFFSLLYPFMPFLDEIDFRESVTKIIGETEYKDEKIKELKVEKRLDLAVIGVLLIILRMSYLSLFCNKESVNEMRLKTTDPSPEAQDMKYLLQNPIGISLIDSAQNCLQYFDIFRKTSMPVLQCAYFLQLYHIFAPEDGDDGDGADTYALNSMVVRMAYSMGLNREPDNFKDVLNDKRQNHLGRKIWHFLVIGDVHNSYAFGTPKLIGDDFYDTKVPFIEEGNENLIDKSLDQYVTKSVFPGYFSIYNSVDQILKLILSVSRRSKVSEICKILNQFEIGIAEQYGTLSDCLKPKENLIHIFARNMPVKMYISLKSFLVSVYFHLFLYYEHKNDSLSFFYLRKILKTGAGDIMPHYFELLGNSEVVCDMVINPKLIQIIHKANQINIALIIRVNMSIYRMKNSQHHAENCKKDDFYYSYYKELCKFSSCLTRCAEVGIAAVSKLSTRYYYAWKITKGHNFLLKTITSMEFYEKESTNAQEITLPKYKLEQIADLENICEVALNKLGKTSVMGDEFCSNVNYKKYKGDQTYSTSSESSSTPNKDSPLDSRKYTNDFGLDLVNNQEIDKIWLQMLSLKSEEAQQQRQQESQPFTSSQSQSQSPLTSANQGYMPRPESRRGSYYGNTPFALENLNFDGFGGQSKSSNNGEADLSSFDFFVDLPFDQLFTN
Protein: RNA-binding motif protein X-linked 2 (RNA-binding motif protein, X-linked 2 isoform X1) (F1RAH8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- MCG1346-like protein
- Splicing factor 3B subunit 1
- Splicing factor 3B subunit 2
- Splicing factor 3B subunit 3
- BUD13 homolog
- Smad nuclear-interacting protein
- Cell division cycle 5-like protein
- Splicing factor 3B subunit 4
- Activating signal cointegrator 1 complex subunit 3
- Pre-mRNA-processing factor 19
Sequence:
MNPLTKVKLINELNEREAQLGIKETVSWHSVYKNSAWVFIGGFPYELTEGDIICVFSQYGEIANINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVANYRPPKDTDDIDDITKQLREEGCAPKPVSSSEEESAEEYAVPVKKPKKDKKEKKKKKKEKKEKKKALKEEKREGRSESSASSPIRVKKEKEDVAYEKYSVKGPAANRRDRADEQEQLKEKEREREEGKKTDRRHAETQQRERDREGEREGDKERERDRGRQRDGERQRERDGGRQRDGERDRERERDGGRQRDGERQRERDGGRQRDGERDRERERDGGRQRDGDRDREQERDGGRQRDVERDRERERDGGRQRDGDRDQEQERDGGRQRDVEKVKERERDGGRQRDGERDRERERDGGRQRDEERVRQRERDRDRERDRGNGKHRDHSREREHRRN
Protein: 14-3-3 domain-containing protein (Q5ZKJ2)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Cell division cycle 25B.
- Uncharacterized protein.
- 14-3-3 protein zeta
- 14-3-3 protein beta/alpha
- 14-3-3 protein epsilon
- SAC domain-containing protein.
- Rhodanese domain-containing protein.
- NSFL1 cofactor p47
Sequence:
MGDREQLLQRARLAEQAERYDDMASAMKSVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKYLIKNCNDFQYESKVFYLKMKGDYYRYLAEVAAGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGNN
Protein: Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1) (Q6J9G0)
Organism: Homo sapiens (Human)
Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein PALS2
Sequence:
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYSML
Protein: Glutamate decarboxylase (EC 4.1.1.15) (Q5E5Y7)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Function: Catalyzes the pyridoxal-dependent decarboxylation of glutamate to produce 4-aminobutanoate. Has weak activity with aspartate, but cannot complement an E.coli panD deletion mutant.
Interaction partners:
- Pantothenate synthetase
- Glutamate synthase large chain
- Glutaminase
- Glutamine synthetase
- Glutathione hydrolase proenzyme
- Bifunctional protein PutA
- NAD-specific glutamate dehydrogenase
- Aspartate 1-decarboxylase
- Glutamate synthase, 4Fe-4S protein, small subunit
- Adenylosuccinate synthetase
Sequence:
MPLHSKNAVRDDLLDDIYSSADLSLSMPKYKMPEQEHDPRHAYQVIHDELMMDGNSRQNLATFCQTWVEDEVHKLMDECIDKNMIDKDEYPQTAELESRCVHMLADLWNSPDAENTLGCSTTGSSEAAMLGGMALKWAWREKMKKLGKPTDKPNMICGPVQVCWHKFARYWDIELREIPMEGDRLIMTPEEVIKRCDENTIGVVPTLGVTFTCQYEPVKAVHEALDKLQEETGLDIPMHIDAASGGFLAPFCDPDLEWDFRLPRVKSINASGHKFGLSPLGVGWVIWRDASALHEDLIFNVNYLGGNMPTFALNFSRPGGQIVAQYYNFLRLGKEGYRKIHQACYDTAVYLSSEIEKLGMFEIIYDGKGGIPAMSWSLKEGVDPGFNLFDLSDRIRSRGWQIAAYAMPPKREDLVIMRILVRHGFSRDQADLLVADLKHCVEFFAKHPISHGSDELESSGFNHG
Protein: GDP-mannose pyrophosphatase (EC 3.6.1.-) (GDP-mannose hydrolase) (GDPMK) (P37128)
Organism: Escherichia coli (strain K12)
Function: Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP.
Interaction partners:
- GDP-mannose mannosyl hydrolase
- Bifunctional NAD
Sequence:
MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNTKKKTVVLIRQFRVATWVNGNESGQLIESCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQTSHLMD
Protein: Nuclear factor interleukin-3-regulated protein (Q68EL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as a transcriptional regulator of a number of proteins of the circadian clock.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Period circadian protein homolog 2
- Nuclear receptor subfamily 1 group D member 1
- Period circadian clock 3.
- Basic helix-loop-helix family, member e40.
- BHLH-PAS transcription factor
Sequence:
MQAIKKEPPCSGPYGGEDALVLAVALQGTDRDLINHKLSTLPFKSKSTSCRRKREFIPDEKKDNLYWERRRKNNEAAKRSREKRRLNDMVLENKLMALGEENASLKAELLSLKLRFGLVSSAAYAQEVQNISTSTAALYQDFMSPSATKDSYPSDLEPTRLTSSCISVIKHSPHSALSDGSDSSTVTQGSPLINISRSPDSIKQEPLETGRYSKERISPYELYRNYLSSPFPGNFSQPSPFLQIARSSSNSPRTSDGDDGAVSKSSDNEDEQQVPKGPVPTRSDSQSVIVSTLKVPDSSASALPHKLRIKARAIQIKVEAIDPDYESSGKSSFPVDMSARRRYQMSQCATPEYIQSSLSPMSFQMTNVQDWNHRPKEWHEDHQEALTSYKYRQCPDSPRPVPNKLIVDLENDSYANSESENLYLKQGIEDLSAEVACLKRLISKQQGSVIESTKSTTEIDSS