wanglab/gogpt-training-data huggingface dataset:
Protein: 26S proteasome non-ATPase regulatory subunit 4 homolog (26S proteasome regulatory subunit RPN10) (AtRPN10) (26S proteasome regulatory subunit S5A homolog) (Multiubiquitin chain-binding protein 1) (AtMCB1) (P55034)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in maintaining the structural integrity of the 19S regulatory particle (RP), subcomplex of the 26S proteasome. Plays a major role in both the direct and indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a potential docking subunit for both ubiquitin receptors RAD23s and DSK2s. Plays a role in the growth and development via the proteasome-dependent degradation of the ABA-signaling protein ABI5/DPBF1. Plays an important role for balancing cell expansion with cell proliferation rates during shoot development.
Interaction partners:
- 26S proteasome regulatory subunit 7 homolog A
- Proteasome subunit beta type-4
- Proteasome subunit beta type-6
- 26S proteasome non-ATPase regulatory subunit 13 homolog B
- 26S proteasome regulatory subunit RPN13
- Proteasome subunit alpha type-3
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- Proteasome activator subunit 4
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 8 homolog A
Sequence:
MVLEATMICIDNSEWMRNGDYSPSRLQAQTEAVNLLCGAKTQSNPENTVGILTMAGKGVRVLTTPTSDLGKILACMHGLDVGGEINLTAAIQIAQLALKHRQNKNQRQRIIVFAGSPIKYEKKALEIVGKRLKKNSVSLDIVNFGEDDDEEKPQKLEALLTAVNNNDGSHIVHVPSGANALSDVLLSTPVFTGDEGASGYVSAAAAAAAAGGDFDFGVDPNIDPELALALRVSMEEERARQEAAAKKAADEAGQKDKDGDTASASQETVARTTDKNAEPMDEDSALLDQAIAMSVGDVNMSEAADEDQDLALALQMSMSGEESSEATGAGNNLLGNQAFISSVLSSLPGVDPNDPAVKELLASLPDESKRTEEEESSSKKGEDEKK
Protein: Sodium/potassium-transporting ATPase subunit alpha (Q6P1S7)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}.
Interaction partners:
Sequence:
MGYGAGRDKYEPAATSEQGGKKKKGKGKDKDMDELKKELTMEDHKLSLDELHRKFGTDMQRGLSTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGITAATEEEPTNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKLSINAEDVVLGDLVEVKGGDRIPADVRIISAHGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGVVVNTGDRTVMGRIATLASGLEGGRTPIAIEIEHFIHIITGVAVFLGVSFFILSLILQYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGASFDKSSPTWTALSRVAGLCNRAVFQAGQENTPILKRDVAGDASESALLKCIELCCGSVRDMREKNPKVAEIPFNSTNKYQLSVHKNANPSESRYILVMKGAPERILDRCSTIVLQGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLALSDDQFPDGFQFDTEEVNFPTENLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVIHGSDLKDMAQEQIDDILKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIVANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPWTLLGIRVNWDDRWNNDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLLIFIYDEVRKLIIRRSPGGWVEKETYY
Protein: G-protein coupled receptor 3 (GPCR21) (P35413)
Organism: Mus musculus (Mouse)
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes.
Subcellular location: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:34871769}.
Interaction partners:
- Beta-arrestin-2
- N-arachidonyl glycine receptor
- Guanine nucleotide-binding protein G
Sequence:
MMWGAGSSMAWFSAGSGSVNVSSVDPVEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAADFCIGSPEMSLMLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCRDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDADSPRLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSPSDV
Protein: Uncharacterized protein C14F5.02 (O60099)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Transport protein particle subunit trs120
- Transport protein particle 20 kDa subunit
- Transport protein particle subunit trs23
- Transport protein particle subunit trs31
- Transport protein particle subunit bet5
- Uncharacterized protein C13G6.05c
- Uncharacterized protein C15A10.12c
- Transport protein particle subunit bet3
- Protein transport protein sec23-2
- Transport protein particle subunit trs85-1
Sequence:
MRNLNTELDFFVSFSALKEENISQLKVYWAQSNLVELYYGESFYINIVCSRPIVDENVTTWPENEGFRIEGTLLESLVESVTSASNYPKVNAFSLMCSGIPSFIWVEDDKQYALWACLAQLDSYSYPNHKLEIHVYKHILPDLPQSSEVDRNSETEGTREENSNTSDWDEQNEYVSEVEGDYNLLGSLSNDIQFRSNPPVISGAYVFGESDVANELKDPSRKTKTRKKVFECSVPVVLKLRSYALNESNQYITSIVSPDSSCENIRILGFKAETNAATISLFAPKTPEKLQITLSSSDVFTIIHLLQIPDNIKHIELQCFCKVIVAQKLSETLVESMPFTYKHPPVLITRRTPTKTHTKQLSSSGNVSAAQSISSLNLLEISASSPSYVPSGSSFSVRANLYNPLDFSIDLLIRIPLYCYDDCLTNKEHSTSKSEEKSSELLKYPNGHTISPGIIALSTKLYTGSIFPKCEKDFDLHFLAYKPGSYDLSSISIEDVNHVVHKPRKLSKELQIIVT
Protein: Amino acid transporter (O77062)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
Interaction partners:
- LD37241p
- GH04846p
- Glutamine synthetase 2 cytoplasmic
- Delta-1-pyrroline-5-carboxylate synthase
- Glutamine synthetase 1, mitochondrial
- LD25378p
- Amino acid transporter protein JHI-21
Sequence:
MTRPKQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASKVLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQPMENWEFKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCLDNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLSKNDLASVDRLNAEPHELLELGPNGHEMKE
Protein: Dystrobrevin (A0A8I6AQU5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR038204}.
Interaction partners:
Sequence:
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVARLEAVLSTMFYQLNKRMPSTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVPPRPVTSMNDTLFSHSVPSSGSPFITRSMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDVSFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKTQGAGSPRSSPSHTISRPIPMPIRSTSACSTPAYTPQDSLTGVGGDVQEAFAQSSRRNLRNDLLVAADSITNTMSSLVKELNSEVASETESTVDSEFSRTQFEDLVPSPTSEKSFLAQIHARKPGYIHGGATSTMHGDMVPEDGDPYPQPEDGNYENESVRQLENELQMEEYLKQKLQDEAYQRHVSTETRLKHPCPVTETKWRVLFWGFVIVGGFLSLALQIYFWGLF
Protein: Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) (Q8IVL0)
Organism: Homo sapiens (Human)
Function: Plays a role in cell migration. May be involved in neuron regeneration. May regulate IL2 production by T-cells.
Subcellular location: Nucleus outer membrane {ECO:0000250|UniProtKB:Q80TN7}.
Interaction partners:
- Calponin-1
Sequence:
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPPSEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGSSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQSSSGVNGNVQPPSTAGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQSSTATSPTPSSDRLKPPVSEGVKTAPSGQKSMLEKFKLVNARTALRPPQPPSSGPSDGGKDDDAFSESGEMEGFNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKNKVCTEKPVKEEKDQVTEMAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTVKQTISPGSTASKESEKFRTTKGSPSQSLSKPITMEKASASSCPAPLEGREAGQASPSGSCTMTVAQSSGQSTGNGAVQLPQQQQHSHPNTATVAPFIYRAHSENEGTALPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTSRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTSRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSSEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLNRIPDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGKWKTVSSGLPEDPEKAGQKASLSVSQTGSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAKASEKGKAPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATSSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKSASAPNTEGVKSSSVMPSPSTTLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTTDVISLSHSLASSPASVHSFTSGGLVWAANMSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYSSTQSCDSESTSHHEDILDSSLESTL
Protein: Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) (P43144)
Organism: Rattus norvegicus (Rat)
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.
Subcellular location: Synaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10713500, ECO:0000269|PubMed:11248107, ECO:0000269|PubMed:12117536, ECO:0000269|PubMed:7954834}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetylcholine receptor subunit alpha
- Acetylcholine receptor subunit delta
- Neuronal acetylcholine receptor subunit alpha-5
- Acetylcholine receptor subunit epsilon
- Neuronal acetylcholine receptor subunit alpha-3
- Acetylcholine receptor subunit beta
- Neuronal acetylcholine receptor subunit alpha-10
- Neuronal acetylcholine receptor subunit beta-3
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit beta-2
Sequence:
MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD
Protein: Borealin (Cell division cycle-associated protein 8) (Dasra-B) (DasraB) (xDasraB) (Q3KPK4)
Organism: Xenopus laevis (African clawed frog)
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:15260989}. Chromosome, centromere {ECO:0000269|PubMed:15260989}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15260989}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Interaction partners:
Sequence:
MASGKKKTSRKPKNRSVKNEKLASFIKDFDSQVKIITEEMKASVVNILKEVDSQYNIEIIKLPMAIREMCWLDYIAKGGSQKALEAAATVKVDMEEITSTVTKTPFKADKKVKKGKCKPDDETVELNPLKSVIRTKTKAKVAAKKPSTARRTRASVGNVANTSKRTSKRGRATPSASKQAETSLLGYTPAATPRIDTSIFKTPALRTPCMQEPVYTFSANGSPLAGMDELFINVPARDGKIIRLLASEVDGLDINRLDQQAFENIKLLSSRLERLCKKLK
Protein: 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (P46471)
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P35998}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:P35998}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 1
- Proteasome subunit alpha type-2
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome regulatory subunit 4
- 26S proteasome regulatory subunit 6A
Sequence:
MPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
Protein: MKIAA0327 splice variant 1 (Q8CHE5)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
FRGNCRRAMATLQKLPQSRMLVLLCALWAALWEAKAGQIRYSVPEEIDKGSFVGSIAKDLGLEPQALEERGVRIVSRGKSQLFALNPRSGSLVTAGRIDREELCAQSTPCLVNFNLLLEDKLTIYSVEVEVTDVNDNAPRFGVEDPELKISETTTPGFRIPLKSAHDADVGENTLQKYKLNSNDHFSLDVRTGADGNKYPELVLERALDREEEAVHHLVLVASDGGNPVRSGTCRIRVKVLDANDNAPAFTQPEYRVRVPENTPVGTRILTVTATDADEGYNAQVTYFQEHDPGETSDAFELKSTSGDITITKSLDYEKAKFHEIDIEAQDGPGLLTRTKVIVTVLDVNDNAPEFYMTSATASVPEDAPLGTVIALFNVHDRDSGQNAVVTCSLPEMLPFKLERSVDSYYRLVTTRALDREQFSFYNITVSAKDGGSPSLSTDAHLLLQVADINDNPPSFPRRVYSAYIPENNPRGTSIFSVLASDPDSNDNAHVTYSLAEDSFQGAPLSSYVSINSDTGVLYALRSFDYEQFQDLQLWVIAADSGNPPLSSNVSLSLFLVDQNDNTPEILYPALPTDGSTGVELAPRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTIAIADNIPEVLADLGSIRTPANPDDSELTLYLVVAVAVVSCVFLAFVIALLALRLRRWHLSRMLQASRDGLGGIPASHFVGVDGVRAFLQTYSHEVSLTADSGKSHIIFPQPNYADTLISQESCEKTDFLSAPQSLLDDKREETPQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) (P14869)
Organism: Mus musculus (Mouse)
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P05388}. Cytoplasm {ECO:0000250|UniProtKB:P05388}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:P05388}.
Interaction partners:
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS7
- Elongation factor 2
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL19
Sequence:
MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLIIQQVFDNGSIYNPEVLDITEQALHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETEYTFPLTEKVKAFLADPSAFAAAAPAAAATTAAPAAAAAPAKAEAKEESEESDEDMGFGLFD
Protein: Rhoptry protein ROP14 (C6KSX6)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MDKNDVKEETKILLNDKDIDKNKKVGKIRYCINNFFKTLFQKNVQYDTFFYKNKSLENTFWSSQIIYTRILLISCLFSFIVSWNQNVALIGENGLTPAKNYVDKMFDELQNESIWVKFQNFHSLFWFIPASDFNINLLAIIGIVLSCFSLLFNYTNLVTLVPIYIILQSIYSIGNIWFNYVYEIEILELLFLCFFLVPFCGNHLKKRFSPTCLIKYICRCFVFKVLIGTSLIRFKNSDLWGKLLGKYYLYETQPLPTSISYLFHSCITLSKLDNIFCILTECVFSFLILFPIRSFRLVGGSLIFIYCILNFITGNSYLFYFLLIAPLMFCFDDKILLRLFFFKWKRYEIINIVKEKLANKNKSKRYFKSFDIFYFTGFNSDDLIKIYDNYFNIKYQKAYLGKSPKKNNTLNKYNEQSSYDDNYEQEDEEHYYYDDEEDNEYDEDNYDISYNNSLNYQITKEQIHNNQSPQKQKEQQQQYRALIPKSSSKEINLFYKKQNILKSIKNDLYNTFYWLFSQKGLQYIIKNYNVSVEIFIHIICSLLIIIFNSIVTISIYPITSILFYIYIVLFLSYVIFLFGYTKNIFSRIISQLSLLLVILLIYSNQIFLHGFVNIYYNSLFFIHLLTLCILSMFYLNNKRFIFKFTTQYFYFILFIYFAYFFLQNILSPNQIMNAQYGSFEIMNIYGSFGKIKKNRKEILIEGTQSEKIDDNTTWHTYEFYCKPDNIYKNMCTQFRLLYNFIPVLYIDRLDWQFNTLSDKEDETILQNEWFKNFLIKLSNNDKNILSLLYKNPFQNIKNINNKNTIFLRISNATYKFAKNGQKNWWDVVSSKVIVNPHQVSKLPEQVRLNLYNMHEQIEQAKRIKLNNIGNKDLYDENMLNYKKKYNMRKYKIMDTNMDDIERTKETKNDIIINDKIIGIDFKYDNVDNDFESTYKEESYPNLRKIKKEKHNEAKERHEQNFNKQYERVKKILEDHKKILEDENEIINKEKKKLQNQKDLLNKEKQKLQEEKKKLVYQKKMQEHNMLEQDQKIQEEKKKLLYQKKMQEHNMLEQDQKIQEEKKKLLYQKKMQEHNMLEQDKKIQEEKFMEKKQKLTEQFLEQKQKEDEQILERNKIEKQNIMNKLKKLEEEKNQFEKKKLFLEQKKIQEQKAIDHEKKYLQQQQNKLLQIKKEIQHQKEEQQHKVDEQLNQKLKNEFMLQNEDTINKKKIYYPIHNNNTNVNNNSDMYDMNKYNTKELNEKINNEIESELENNVEPFPHQIIYNNGKHEQVKYENKYLKDHLNDHLNKHFKNNNHNKLKGSYNKTTQQNYSNDDDISYLGQKHQINNKFEKIENKINNEQSNNKLQKFTVDEKIKNELDNAIKNSYSKYNLLNNYTNKINKLGLLNVYNNPNNVSNINTLKYKPYDKYHNESYITDTVNENIE
Protein: Transmembrane protein (Q387X9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKRLASFGLITLVGPLLFATMCASAAMAGAGSAAFPRRLKFGDVPVAPSPIEPMSSESRQYLIGIFSALFVSVAVILAVRALMMVDYSNDTLLMVEMPEPVANM
Protein: Minovincinine 19-hydroxy-O-acetyltransferase (EC 2.3.1.-) (Q8GZU0)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of the monoterpenoid indole alkaloids (MIAs, e.g. echitovenine, tabersonine, lochnericine, 19-hydroxytabersonine and horhammericine) biosynthetic pathway; MIAs are used in cancer treatment and other medical applications. Acyltransferase catalyzing the conversion of (+)-minovincinine to (+)-echitovenine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29438577}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:29438577}.
Interaction partners:
Sequence:
MDSITMVETETLSKTLIKPSSPTPQSLSHYNLSYNDQNIYPEYIFAGFFYSNPDGHEISTIREQLQNSLSKTLVSYYPFAGKVVKNDYIHCNDDGIEFVDVRIHCRMNDILKPELRSYASELIRPNRSTVGSEDSTALVQLSHFDCGGVAVAFGISHKVADAATILSFIKDWAASTCDLSSSHDVSTPVLVSDSIFPRQDNIICGQFPASPNCVRKRFLFSPEAIERLKSKAIEFGIEKPTRVEVLTAFLCRCATVAGKSAAKNNNCGQSLPFAVIQAVNLRPLLELPKNSVGNLISIYFSTIKENDTVNIEQEFTKLVIGELRKAKDKLKNLSQEKLNYVARMQDFANCLKELDISSFFDMENVDIDAYLFSSWCRFPFYDIDFGLGKPIWVCMFQPHFKNCIILMDYPFGDDYGIEALITLEQEKMPAFENNELLLSFASN
Protein: Neurturin (Q99748)
Organism: Homo sapiens (Human)
Function: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P97463}.
Interaction partners:
- GDNF family receptor alpha-2
- Proto-oncogene tyrosine-protein kinase receptor Ret
- GDNF family receptor alpha-1
- GDNF family receptor alpha-3
- GDNF family receptor alpha-4
- High affinity nerve growth factor receptor
- Persephin
- Syndecan-3
- Artemin
- Glial cell line-derived neurotrophic factor
Sequence:
MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAHSRYHTVHELSARECACV
Protein: Homeobox protein (NK2 homeobox 4b) (Q9I8L7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MSLSPKHSTPFSVSDILSPIEETFKKFAAMESSASLASPLYRQSQVSQANLQQHSMSHNAYHMPHSQFSHSTMGGYCNGTIGAMGDLPSYQESMRNGATATAWYGSNPEPRYPTISRFMGPSAGMNMGTLPGMDASKSMVTLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKASQQQDSGNMCAQQSPRRVALPVLVKDGKPCQNGSGTPTPIHQQVQSVLGSETLASAEDLEEMSPSPPLMGGLSQTDAALIEYTSSMVSSNLLYGRTW
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9VB73)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Palmitoyltransferase
Sequence:
MTRITWRGHSTQELLSILRLRWSYMKHCWHSLTFNAHMNSSYASDVCLTPIFWFVDNYTHCLGPFFVVGVAALTTSVVSIAYWIGLPFWWAKSQLVTYFLLIVGNWLLLNVVFHYVMAVITPAGHPPEGVSLVEAVSMCGKCIAPKPPRTHHCSICNRCILKMDHHCPWLNNCVGYGNHRYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHGENWTEIEPLEGQPVKFNLSGHIIPVTHPNEYDEFVLPPAVHNLPTPIVDTDAASPGRRRALWFMAFTNVAVVLALGSLSIWHAKLITRGETSVEAHINEAERKRHLQQQRIYINPYNFGTKKNWKLFLGLVRGRSFWRTVLLPSWHKPEGTGLSFHTVNDAPFEDEWP
Protein: Acid ceramidase (EC 3.5.1.23) (Q6PH71)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Neutral ceramidase
- Alkaline ceramidase
- Alkaline ceramidase 1
- Sphingosine kinase 2.
- Ceramide kinase
- Non-lysosomal glucosylceramidase
- Ceramide kinase family protein
- Sphingosine kinase 1.
- Galactocerebrosidase
- 3-dehydrosphinganine reductase
Sequence:
MNNRLNLCFFILSYMCMCLSAQYVPPFTEDCRSGMYPPNGPTFKGDVSWYTVDLDLPASKRWTDVISDKKTEMASMIQAIRDLADAFVPSGKLIQLVDKDLPLMVDTLPYPFNEEIRGIASVSGVPLGEVVLFNIFYEVFTVCTSLVAEDVNGNLIHARNLDFGLFMGWDLKNRSWVITEKLKPLVVNIDFTRNGQTVFKSTNFAGYVGMLTGIHQNSFTLTMNERFSLDGGYIGILEWILGKRDGMWMSFLTRSVLENATSYESAKALLSDTKLLAPAYFILGGNQSGEACIITRSRTQNISPLELNVKNGRWYVLETNYDHWKEPLFLDDRRTPAMKCMNQTTQTNISVKTVYDVLSTKPVLNKLTTYTTLMEVSKGTLESFIRDCPNPCMPW
Protein: LD43670p (Q960M9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATGANLTSGVAGGERRKSSVVEGFGIANNLARLTSMALAHLLYAPPSPKLPQYTPLRRAAIDLLGRGFTVWEPYLDVSKVLLGLLEISCEGKAVPNLNYKLPLTPQADACRTARHALRLIATARPAAFITTMAREVARYNTMQQNAQSINTPLTQSVLHKAKGEILQCVEMLIDKMQSEIAGLLVEVMDIALHCVDGNELKNRGLAELCPAICKFNQISHCAQTRRIAVGANSGNLAIYELRQNKCQMIPAHTHPITSLAFSPDGKYLVSYSCAENRLSFWQTSTGMFGLGQSQTRCTKGYSTAPIPDVSRLNPMRLAKLVWINNRTVTLMLADGSETRFNV