wanglab/gogpt-training-data huggingface dataset:
Protein: CHAT domain-containing protein (Q38C46)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAQPVDLCELYSSYCKEEGCKPNTAVLQYIIDCGRRYPLEKLILGNNYLGPRGLRPIVRLVDYCPTMMHLNIDENGADNDTVSLLCDVLMTHKGMQTISLRGNPITATGGKKLLALAEKNPKITHIDLDNTDVFQALLLKIYAATKANRDRIGRGAVHLIPTSMDEKELMAIVSSANTKMTHTFTEKPVIRQLPSVKKGEPTPVESSVSPRVVSPVERSTTFPKPGRAWGGGQPSCETKSPLARRKGRARPPIPPITSRLPESQRLELQKEYRQRAMILREVNTSQASKVANRVREELMLLERNFRSEPSTQLGWNVEAAGTEAGEGKGDHSFDQDLEAIEGYVDTNQEETEHGAQPQMQHVEEGSADNSRPEGLINRSSNGAFGPPPNFREPQQQVLLRRDETSPEVPFGNAGGVTSLKSINLSAISPSSNSPDFTGKIVLQSGTPNTNTEKESEDNVHTFMESPAWMTLGSGEKLQYLFNSGCRAYVSQKFDTSYMAWKEAMSIATSVKDRQWMAVLSNNLQRLSYEMLVREGTEFLDEFKLEDADVAFQRALEVARRANNAKWESDMHKARRDVQVAIFHKTDEAALRMFEKAQTTEPRKVTSDDYFVVAGSDVLIQHTEAYVNEWACMLLVKEAVELWAAAIRVTERIGGTASHTLQVSVKESLTTVSYFLAQRCFDVEDTQSLSWMSTSRYNYHECIMLIKLWTDMTSSADFRENHKLFAAIAAAQIGNLYLATNQLKEAEAQFSALTSLGEELRDSILIAAGHTFRALLNWQCARYPAAEEHFRTAVARWGALRDVVRRERLEQNSFVGNTTGVNSTSNSSSNVVDSLTKVTTGRYHVDGVSDAVFSRCNELSRLLLLLPRGYVSMMECVSYNYLVSSLACKYRYSEALEVLECGLVCKYRDMLFDKLEMNFSTRPTFAQITATPSLVHSPLVYYLTTRRYEWSSTKCSYDVEESLLTWIVPQVGDMRFIEIPLMKEMKVLSVDSLVQRVRKSLLLAPLDRLGANNARSGGTSGDSCGGEKAVDAPEIITELPNKTWVEPLKTLYNIFIEPIAAYIRSSDPRLLAKNGVVTIIPTDGLWLVPFNALMSRNGNFVIEDFAFQLGFSATQCRLAALSAKRVQQRCLFQNLVLVQKQADATEQLMSHLLFPLDAHRSESEGAVVMQTLAQNKRHVRHQCNSYVTSEITSSEVLLHDIEKLKEHLPRSRTVHIAASTTSGFRNEDAGGGAICIAGTKGDLQLLRSSDIARMELFAEHVILSNANMSPSGIVGTHDDVLCLTRGFLASGVPCVITSQWCTPDMVPAMLFSRFYQHQSAPNKRTRSSLLSRDSIGLLPASGTQQNALSRKEEGSDRCNDNLNWHKALFLAQAIRGLLEDDTFRYSPRSWAGYYCIGYGLMPPGEA
Protein: Saposin A (Q54Q68)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Chitinase domain-containing protein 1
Sequence:
MKSIFLICLLVIASLFIGNSFANDSIKADALECEMCNFVTGWAEEFVTKNATEQEIIQKLEDACNILPKEYAQDCVEIINNYGVLMVRLLINRESPENVCLMMELCSKSSSELIMPINVVAVGDEVDNVEGSGECLVCEFISEKIVTYLEANQTETQILQYLDNDCKLLKSDNWISTCQNLIQEYEPQIIAVVEGFMAPSELCQKIKFCSSSSSTNDFDFIGSSTTDCEICTFISGYAENFLEENKTLEDIIKVVDDFCKILPAAYKTDCVAMASNYIPAIIKMLENDNSPGQVCQKLNLCPAPTPTSTPSTIKIDVNINKCEICETVIGFAEKYLGSALDSQTVKTFLQNECNKLPGVVGDVCNEVVNEYLEFAVTQLEAKFNPTEICQLFSFCTAGSESSDASEIKINNNSYIDCQICEVLANFVVYDKNYTTHFEDKLNKLCSCLSRSLIEPCLNFVSQYGSDLVQIIVQGGESAAEACNQIAQCPTSSSSSYSGSASGASSGSASGSASGSGSGGYLF
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CU1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MQGTMYWVVFLVAVLQGIHLVSGQDIVNQQEFEALCRMINWAERGLKHIKLAKQVTEEALSIGIRYLEVADADSAAQLGAAEHDACMDKREVREKNCGLYKTFWEESQRLLKEKHERSQAHHRGRNSLQYHTAEEIKSKVMEVADIFHEVKWELLELKVNNMEEQLNQALYGRTYSAEEIREREERSRVCGQSSRSEMIIGGQSLVMDLLCLCAMHSSWKEMRVCCADCTTGENGNTWNPGSNGAPRWKFLKQKCAGATTSYVSVRKTLRGAKQDFMDAVTEISANRRTNLYKLGEKQNKEIKDCGADKNSKEGICVFYRERDGVVFWMKALENVDNKMEVLLQDRTKKTSKLERIKELSQEIESLIKGDTGRGRQQGRQKRSVDTENSVPETPADPSDPTQSTTHTNEKKRIVRKPISTGNNASKSYGGDEVDSYDSKCDGENSACSDSPAKPTVKSSKSAINCPLGLILLLV
Protein: DOCK family protein (Q54DW1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS30
- ELMO domain-containing protein F
- Glutathione S-transferase domain-containing protein
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein uL6
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS7
Sequence:
MIEIKNKNMKSSIGDDDDDYGGGGNNNNNNNNNNISSSIVVSSYPHSPPNTPNNNNNNNNTNGNKKQHHIQGEFDYYDEEEEEEEESDIGIQNRLFLNPNYKQHHRSRSITISGSPTPKNYTQNQRYSDDTVLLKSSNGCGGNNNNSSSNTATTLSVGSYESPCRLLSSSGGSNSNGVIFSPISVTPTASPLNTPVSSHTLQSVTLTLSPFSIQKRSATIQLPSTTTTTTTTTTTTTTTTTTDQNLLTPPATPQTPQQKVFSPPRRRNTCANLTNKLYSVYSPHKSPPDNNNNSNNSNEVIVNSPISISLSSQKYLSNHHHQQHQHHQSVSLSDYLCNKTSTDNENDDVSTTTTTTNTNKSNNNNNNNNNNNNNNNNNGMNLLNKIKSKLKEDKIKHYETIFSAYNESYETLKEGGISVLNGEVLVCIFQYLDIKEICCLAQTCSWWRIVSEQNVLWLKKFNERFQRPKTIIDRFSPNESWKELYIQHYFLDTSYMEFERLLSLFPVTVEYELDITILLSKVLNYLKHTECRSEYIDKLEHLKNIHLTFSNKIEAANCYIKHSELISWDSNQYFQQEFGYPRESHSDRKERILKAAIHLLFESKYWERCLILINQLRKKYKKELKKQNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEINNNNNINNNNNENNENNENNNNNNCNIPIKNLLVLKMIEISKLEHQCYQSIESKERFFEEYFFVEFRGKGSFPKSVDGKDFIFRGKELEKLGSFVSRLKNRYPGAQVIPKQQGVDLSQTNGQFIHIRPCKPVLLPKDIISSGSGRGGNICNNSSKIISGISGYSNKTHYKSLKSFINNNSKVFYFSAPFKKNLNNNNINNNNNNNNNNNNNNNNNEFLMLWTRDTYIISKSIFPSLIRNSMISEIVEIEKNPLENAIESLKRKNKELDKIFNQCKKSMQWNSHLTMSLNGVVDAVVSGGINMYRMFFQQSYLDSNPITHLDLLIKLKQLLLDQKSLLEFGLDIHSHLCPDNMKALQQNMELCFEKWKQIVNELIIPSSSSSSSSSSVNNQDKDKDKRESTEIYDNHVKQLSRSHSDLESILKQLDENTSGSTCTTPTKQQQQQTSSTPSSPLSTINQIQNQLNQNQIEQLLKLQTEKSKEREREKERKKEMESLALLASLELDSTINENIFEMVNTNNNSNNHRNSGKLTSNKPPIQIKSITTPIKQSNQQPNQQSNQQSNQQPLPIQPQRPSSSLSNSSSNITSNTLSIPRPSSSLSNSSPCLSNSPPKLTPTKSTLNINPSPQKKPTSPKTQNKITTKLSSSSSTTSASTSTSNTPKTTTTNSTITNTTSSQTNSTLTSTTTKQTPTKSSNNYLKPPSVARPSTISRSLTSISTPPSTSKSSSSSTTNKLNITTPTKTRPTIGSNTTFITPKKESLPIPITPSSTKKSSSYSLSSTSVPSTTTTTTTSSHSSFTRPTQSTLARKLEVESKKSTTLRIKSKDRPAIIEPKTPQAKKQFIVPTTPTNTTTTTTTTTTKSTGITSSSFKKSLYEIGDPSLISPTMSTTSSSSSSTSSTTSSTTSSSVYSSSMSSSYSSRSSGGIKTSSLSSSSSHMFGGSGIQIKHGNNNSKLSPSSFNPNMIQMKSSSSSSSSSSYSSSSSSTASTTTTPSPPLSTINLNTNTIPSLDISKPIEKPPQPIASKKRLSITDSIKSVVNLLNVDDSKKIKTSTLKSSSISINSSVSSTLKPLPKKRI
Protein: IFNb3 (B7SVJ6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAVLKWLSICLTLFCQGTAASKPCRWTQFRLGKLNDVSIGLLSDMGGLFPLMCAEENVEQMFPEDLYKNTEGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTELNMFQNVIYRQVQNLELCVVGGVWESSGDGWSVTLKTYFNKLNTVLKEKEHSACAWEIVRKEIRENLVQFKKFIDSRVKL
Protein: Uncharacterized protein (Q388T2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDGFTSNSKKGWGSTLAGKQTEFSRRRASIESRQPSSCVGRYVASARTSLASQEQLSRYRRLASNMPKRFLYRHLSLRRKVRPLFICALSLLFAAAMRRVLIRYRKQVRLETVEKVRAAYKIQCMWRDRQQRKRIRQRTAISVLVPFLRSRLTRISRRKELAARFLQRVFRSQKERHFVHWMYKNMKYNQAISLIRFFLQRCVAHRCRENLSLQRDERRAYESQYASRALAIMREERMEVLQIQHMMSRVANTVLTPMIPRVVLEDEILQTTGCGAIPPPPLKVEDVDSDCLTRAAEETDAHTAGSGGKLPLTINELPWTSALHSEEGTRRCLGELFESWLPQCPRAGGEKLDIGGREIDLPSCKGAQALPQLAEDDTGTKRPPHVVTPCGNDGSLKQLIGAFLELLVCTESVERKAVEADIQRRRGEMFRRLDFASSLIQSVGTAPPLYANLLVQLDEPWVVRKAEKLFREEQEKRHKMLEEYMVIPLQFLDRPMRSAAAEERRKWIKQRVKTLRGFIGRRGEETGNARSFVTKNDAQGGSPTGQYSISGNIPCEVYQDTTVVSPIMSVTVQGLVSPRHQRQGLPFITVLPLLTKSGASRHAPQLQHSRPTLHSQHFASVASSWHQVVQNPSRERFPSYDVNNIHSTLATSPRETSFDVERRSEMLTSGYGNENLVGRRSLDPISNGSGRQYVYNTTHRGTFTTSLVSGERSQRVEELEESGTKSGTQLPQSASHLPTGHYSSEGCTVAEPPRGGGRCGGNDQVIRRDETGISQGHTTQKPRFPLLRVSRQLRPEPMQPLQRSEINPPPQLFKSCSSGADYVQLRRICPVAPHDSTTMGGVGSSRFGTSQL
Protein: Probable inactive receptor kinase At3g08680 (Q9C9Y8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000269|PubMed:17397506}; Single-pass membrane protein {ECO:0000269|PubMed:17397506}.
Interaction partners:
Sequence:
MMKIIAAFLFLLVTTFVSRCLSADIESDKQALLEFASLVPHSRKLNWNSTIPICASWTGITCSKNNARVTALRLPGSGLYGPLPEKTFEKLDALRIISLRSNHLQGNIPSVILSLPFIRSLYFHENNFSGTIPPVLSHRLVNLDLSANSLSGNIPTSLQNLTQLTDLSLQNNSLSGPIPNLPPRLKYLNLSFNNLNGSVPSSVKSFPASSFQGNSLLCGAPLTPCPENTTAPSPSPTTPTEGPGTTNIGRGTAKKVLSTGAIVGIAVGGSVLLFIILAIITLCCAKKRDGGQDSTAVPKAKPGRSDNKAEEFGSGVQEAEKNKLVFFEGSSYNFDLEDLLRASAEVLGKGSYGTTYKAILEEGTTVVVKRLKEVAAGKREFEQQMEAVGRISPHVNVAPLRAYYFSKDEKLLVYDYYQGGNFSMLLHGNNEGGRAALDWETRLRICLEAARGISHIHSASGAKLLHGNIKSPNVLLTQELHVCVSDFGIAPLMSHHTLIPSRSLGYRAPEAIETRKHTQKSDVYSFGVLLLEMLTGKAAGKTTGHEEVVDLPKWVQSVVREEWTGEVFDVELIKQQHNVEEEMVQMLQIAMACVSKHPDSRPSMEEVVNMMEEIRPSGSGPGSGNRASSPEMIRSSDSPV
Protein: 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB (EC 2.1.1.185) (23S rRNA (guanosine2251 2'-O)-methyltransferase) (23S rRNA Gm2251 2'-O-methyltransferase) (P63177)
Organism: Escherichia coli (strain K12)
Function: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- tRNA
- Ribosomal RNA large subunit methyltransferase H-methyltransferase)
- 23S rRNA
- Ribonuclease R
- Ribosomal RNA large subunit methyltransferase M
- Ribosomal RNA large subunit methyltransferase E
- Bifunctional NAD
- Ribosomal RNA small subunit methyltransferase H
- Large ribosomal subunit protein uL11
- tRNA
Sequence:
MSEMIYGIHAVQALLERAPERFQEVFILKGREDKRLLPLIHALESQGVVIQLANRQYLDEKSDGAVHQGIIARVKPGRQYQENDLPDLIASLDQPFLLILDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAESVPLIRVTNLARTMRMLQEENIWIVGTAGEADHTLYQSKMTGRLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGICLFEAVRQRS
Protein: t-SNARE coiled-coil homology domain-containing protein (Q381F4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Syntaxin binding protein 1, putative
- Syntaxin 5
- Paraflagellar rod component
- Soluble N-ethylmaleimide sensitive factor
- Soluble N-ethylmaleimide sensitive factor
- Synaptobrevin-type vesicle transport protein, putative
- Longin domain-containing protein
- Vesicle-associated membrane protein, putative
- SNARE protein, putative
- Vesicle-fusing ATPase
Sequence:
MNSQRSEYRSLAGGGEGGRRPPIPRRSAPPEETDDVKQSLLRYVDLGGMRVEEQIQREKLVEAVAIKEGVEDLRAVAEDFALLVEQQQEPLDAVRVNVTAALDSVAAGREQIAEASERNASSRKLFCFFPIFLTIVAIGSLVALFFKGKIYKNT
Protein: Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) (Q9QXY1)
Organism: Mus musculus (Mouse)
Function: Tjp1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PatJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (By similarity). Promotes cell-cycle progression through the sequestration of cyclin D1 (Ccnd1) at tight junctions during mitosis which prevents Ccnd1 degradation during M-phase and enables S-phase transition. With Tjp1 and Tjp2, participates in the junctional retention and stability of the transcription factor DbpA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to Tjp2, Tjp3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21411630}; Peripheral membrane protein {ECO:0000269|PubMed:21411630}; Cytoplasmic side {ECO:0000269|PubMed:21411630}. Cell junction, tight junction {ECO:0000269|PubMed:10601346, ECO:0000269|PubMed:14622136, ECO:0000269|PubMed:19538286, ECO:0000269|PubMed:21411630}. Nucleus {ECO:0000250|UniProtKB:O95049}. Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (By similarity). Shows an epithelial-specific tight junction localization in a Tjp1/Tjp2-dependent fashion (PubMed:21411630). {ECO:0000250|UniProtKB:O95049, ECO:0000269|PubMed:21411630}.
Interaction partners:
- Occludin
- MARVEL domain-containing protein 2
- InaD-like protein
- Claudin-1
- Claudin-3
- Tight junction protein 2
- Tight junction protein 1
- Claudin-2
- Claudin-5
- Claudin-7
Sequence:
MEELTIWEQHTATLYKDPRRGFGIAVSGGHDRASGSVVVSDVVPGSPAEGRLRTGDHIVMVNGVSVENVTSAFAIQILKTCTKTANVTVKRPRRVQLPATKASPASGHQLSDQEEADHGRGYEGDSSSGSGRSWGERSRRSRAGRRGRVGSHGRRSSGGGSEANGLDLVSGYKRLPKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITESGLAARNHGLQEGDLILQINGVSSANLSLSDTRRLIEKSEGELTLLVLRDSGQFLVNIPPAVSDSDSSLMEDISDLTSELSQAPPSHVPPPPLKGQRSPEDSQTDSPVETPQPRRRERSVNSRAIAEPESPGESRYDIYRVPSRQSLEDRGYSPDTRVVSFPKGASIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDEILQVNGMPFRNLTREEAVQFLLGLPPGEDMELVTQSKTGHSLRRWSQSRVGDSFYIRTHFELEPSPPYGLGFTRGDVFHVVDTLYPGSGPGHGHSSHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLEAAQRAAGVGPGASVGSNPRAEFWRLRSLRRGTKKASTQRSREDLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAMKKLTTEMPEEFEIAESMSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIERLNYVQYYPIVIFCAPESRPALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATIPLHGTSDSWYQEVKAVIQQQQARPIWTAEDQLNSSSEDLDLTGHGLAASSGDLSCDSRTNSDYEDTDGEGAYTDREGGPQDVDEEVAPTALARSSEPVWVDDHQGLMGHGTTITDKWETQADSHYTQDQRRQDSMRTYKHEALRKKFTRARDVESSDDEGYDWGPATDL
Protein: DNA-binding protein (Q729U7)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- AMP-binding protein
- AMP-binding enzyme family protein
- Cyclase, putative
Sequence:
MSTQDKPYKEIAPRLAGLRDAVGFSPDDLAAKVGVTAADVLRYESGEVEIPVSYLTDVARECRVDLTALISGGDAHLQDFTIVRKGQGLSVQRRKDYDYWNLASRFTNRRMEPFIVRVPAKDESELNFNYHRGQEFIYILEGRMEVRLGDKVHVLEPGDSMYFSSRIPHALRGLDGADAVFLDVIS
Protein: VWFA domain-containing protein (Q9TXR6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPSHTEIKTPVRGLFGIGTSHGGPGTHSDPIVITKDFDRDTLEFVDEGQVQKPGASNIIEVKATVSTPNRQLENTVNNAVNKELNRAIPKVMDRMRGSTMTMDNGMRKELEEALVDELAKNLGETIDNTDITEEDLEKLIEEGFDEVRKIDQETTTTTTTKAPPTTRTPPTTRTPPTTSQPAEFNIDDDDYESSEDISESHTTPPTQTPPTQTPPTTTTTRRVTVVVTSPTTTTPRRTITTRIWTTTTTQAPPTEAPPTEAPPTTQTTPTSWTRPTDGRVHVMPGIRVTETPPTIQTPPPTTQTPPTTQTSSTTQTPRTKQTWAPWTPPTTTTRQTPPTTQAPPITPPPYRPPTSVVTYGPESEEIQHAEHAENGQISAIPTRKPTLIEVSPSTHHHHGIVNLESNEEDYESTVTSKPVIMFTTESTVVHNLPTKPSSAPTLHPSTFSPPLTSKPRHQSSSSEEIQPNFVIPSGACPTPNRPEIDRNRTDILFLLDSSDNFTEQKFQRAIKLIGETVGQFSNFGADGVQVSLVQYNDEPYLEFSLRKHNCKKHLLADIADTEFMTGGSQLNKALEKVSQFAFTKKRGDRPDAENILIIVTDGQSDARIQEPTRLVKDHNVTVLVISTLEADKNFIINLSAENLYDSDNFGKDLAWKLAKRISDSSPKYSVKNPENSKILTPVLPDLNENLAESPEVLVTTRPENAETAENSGIIDLECVGDGFKVQVNPPAGFRGVAVVKGYQDDARCKATASSSLPLNLFISNNECGVTQVKSSDPNGLNSSLVLHLLHDDELNTAEDRAYLLQCFIGAQNQDAVVSTNLNVVRSELAIAETISLSTLPPTCTYSIRKEGPEGPIVSRAVVGQTVWHRWECDGTNDTNQAYGIQVHSCYASDDVERKFAFVDPRGCSSDLALLTDLTYADDSLTAWAASHVFNVHDAESLKFVCKLSLCTRDGDGCEGVTPPACGNTNKTGLLLTKRLAKGINSVDEALTSALSTNVKLTSGSSDGLEDLLKSATSSYLFWVVALVAVAAIVAISILSRNMAENSDTATTCSDPTTMSESQDFGGSIRSISSPPPPNRQLADFMRSFDRNRYV
Protein: Syntaxin, Qa-SNARE family (Q8I5U8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Alpha-soluble NSF attachment protein, putative
- Protein transport protein SEC22
- SNARE protein, putative
- SNARE protein, putative
- Syntaxin-6, putative
- Vacuolar protein sorting-associated protein 33, putative
- Vacuolar protein sorting-associated protein 16, putative
- Vacuolar protein sorting-associated protein 18, putative
- Vacuolar protein sorting-associated protein 3, putative
- Vesicle transport v-SNARE protein, putative
Sequence:
MSYKNYENNKVNSTSFIVEEEKSEGNEKKIKDNILLIKKNMIYAEENLENLKNNLISKRIIEALHEEIQQIYVKVVETEHLFREWEIRFAENPFEKQKKKYIFEKLNIHFKNEVNKLENISINVKKAANELPNIENGEMNYNNNNNNNINGLLNNKKKGNHKFISSDDTMINNNFVLDLDKTYVNNDDFIESSTLYDYEFDQCSENDLLIENEIINDKYEGIKKIQGQVAQAQEVFKDLANLVFTQKENIEMLNNNLYDTNVNTFKSAKELKKTYDHVKQQRFSWFLAVVTLLIFIYFLYFKIFHFSLFS
Protein: FAD-dependent urate hydroxylase (EC 1.14.13.113) (Flavoprotein urate hydroxylase) (Q6F6Y2)
Organism: Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Function: Catalyzes the hydroxylation of urate to 5-hydroxyisourate (HIU). Is involved in the urate degradation pathway to allantoin.
Interaction partners:
- Xanthine dehydrogenase, large subunit
- Xanthine dehydrogenase, small subunit
Sequence:
MNVVIIGAGMGGLTTGIALKKFGHQVTIFEQAEQILPVGAAISLWSNGVKCLNYLGLNEQIAKLGGQMDNLAYVDGLTGDVMTEFSLQPLIEEVGQRPYPVSRAELQNMLMDEFGREDIHLGKRMVALQQKDDQVEIEFADGSSILADVLVGADGTHSITRTYVLGEKVERRYAGYVNWNGLVDISSDLAPADQWTTYVGEGKRASLMPVADNRFYFFLDVPLEAGLENDKCKYKETLQSYFKGWCPQVQTLIERLDPQKTNRVEICDIEPFAQFYKGRVVLVGDAAHSTTPDIGQGGCQAMEDAIYLARSLQINTLSVEDALRRYQEKRNQRANELVLRARKRCDVTHMKDEAVTTAWYAELRQEKGLHIMNGIISNIVGNPLD
Protein: Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) (P15336)
Organism: Homo sapiens (Human)
Function: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Subcellular location: Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
Interaction partners:
- Transcription factor Jun
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 11
- CREB-binding protein
- Protein c-Fos
- Cyclic AMP-responsive element-binding protein 5
- Cyclic AMP-responsive element-binding protein 1
- Mitogen-activated protein kinase 13
- Interferon regulatory factor 3
Sequence:
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS
Protein: ABC transporter A family member 4 (ABC transporter ABCA.4) (Q555Z5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MESIKNQLIPLLKKNWTLKGKSKIKLLLEILLPLISIGILFGILYLSMIITRDFKERPASGFAFDIAHTKQLLIGSNGGLNSDQRNILDNLKLQVSIQHPEFSNDYINRCFVEFKDIESMDEYFHDPFNYRGVMGGVWFPDDSFNGNTIKYSIRVDSDFTHDNTQQFQDREDSQIYLRHYFTQIQTGVDQAILLTNQIAIPIFATGQRFPNPYISFWEKWTDGRKLILLNTGGVFITASLFATLFTLITNIVIEKETKILEGMKTMGLNSFAYYISNSIISLITLLSSTLLVSIILSASQLVHHVKWITLILILIPYSITLLLIAFILCKFFTKSKYAGLMAFLIVLLLSGIGIIIGRFNISPTLKLLSCLFSPIAISVANYVWCYKDLIVFKEVDINVNMVNEYEIIGMLVFDIFLYILILWYLDNVITGEYGIPKKWYFFLTKNYWRKNKKSNINNNGVFDVEATSCNRNSSYNEKNFEKIEHQLERPTISIRNLRKEFKTGDGNRIAVNDLSIDMYKNRIHSFLGPNGSGKSTTLSMLTGMIEPTSGDALINGFDIRNNIDEIRKHLGVCPQSDIIWEQLTVMEHLEFYAALKGFTNSNQRKVEATKIALEVGLGEKLNAPAGTLSGGQKRKLCLAIAFIGPNSDIILIDEPTSGLDASNRRLIWDFILKYRENKTIILVSHYLEECDILSNTISIIANGELKCNGSSLFLKNRFGVGYLLTISKEHNSINNSNLTKTISDIIFNHIPKGSLLSDAGTELCFRLPNESIGNFSNLFKELDDRKKQLSIENYGISITTLEEVFLKIISNSETNPNFNQSVLNTALKTNSSGIKSYQQLKGLLIKRVKTSRKDIKSFVLSILIPILILAGGLILYKNMRTIDIYNTVTQPLILDFNVYGKSVTPVSIDKVNETMTSLFDNSIGHSDRTTLVPYDELHDYLIHHYFGVPGALYFDFRYFKNVKFLHYNVFFNKDYLHALPIYINFVDSEILRSVTGKRIQTTSLPFEHIQSPLEVASLDVNFVAIVFFIILTLASFSLIAASHAGNISHERSTRVKRLLYISGLRKSIYWLSNLIWDYLQTFILVIFLTIVIIAVDDKFRTHFDLYISGVVLFTFSIIPLSYLMSFKFSSHGKAVGAIFAIHFGVGLIFTVISFILRVWAIKENSISFQFLTDIIEYCFYAISPFFCFSKILAIVTKFPGVSRVDQSFIDYWSFHFGLLPNAILFLHCIVWITWILLIDYSSEIKGKFTISKLFSNSPIPDSNEDSDVSNERIIVKQLLDNNTNGGSGNVYPIIFNNLYKKFNSVGNYKSKIAVYNSTLAIPTGQTFGLLGLNGCGKSTTLGMISGEISPTGGKIKLNGYDLIKNRNDALTSIGYCFQFDALIGLLSAREQLELYCRIKGVDESKIKDTVNAFIQMMDLESISNSNTSGYSGGNKRKVSLSIACIGSPSILLLDEISCGVDACVKRFMWNVLMELKKNKAIILTTHSIAECQAVCDKLTIMKDGKLQALGSNQHIKDKFGSGYSIEVKFKKEYLENGVELFLQSFPSASLIDNQHALSASFELPNPPNNPIKLSSIFSNIEQSLKFILDDYSVSQTSIEQIFIKLTKNSITNIDN
Protein: Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase) (Q76IC5)
Organism: Rattus norvegicus (Rat)
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14600395}.
Interaction partners:
- Prolyl endopeptidase
- Pro-thyrotropin-releasing hormone
- Hexosyltransferase
- Leucine rich repeat containing 25
Sequence:
MEQPRKAVVVTGFGPFGEHAVNASWIAVQELEKLGLGDSVDLHVYEIPVEYQTVQRLIPALWEKHSPQLVVHVGVSGMATTVTLEKCGHNKGYKGLDNCRFCPGSQCCVEDGPESIDSIIDMDAVCKRVTTLGLDVSVTISQDAGRYLCDFTYYTSLYRGRGRSAFVHVPPLGKPYNADQLGRALRAIIEEMLGVLEQAEGDISCCHQL
Protein: Secreted chemorepellent semaphorin 3F (Q8AXA8)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MGTDAAIFRTMGKQTAMRTDQYNSRWLNDPAFVRAQLIPDSSERNDDKLYFFFREKSADAPLSPGVYSRIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGPDGIETHFDELQDVFIQQTQDTKNPVIYAVFSASGSVFKGSAVCVYSMADIRMVFNGP
Protein: Ribitol-5-phosphate transferase FKTN (EC 2.7.8.-) (Fukutin) (Fukuyama-type congenital muscular dystrophy protein) (Ribitol-5-phosphate transferase) (O75072)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:29477842, ECO:0000305|PubMed:26923585}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q8R507}. Nucleus {ECO:0000250|UniProtKB:Q8R507}. Note=In retinal tissue, does not localize with the Golgi apparatus. {ECO:0000250|UniProtKB:Q8R507}.
Interaction partners:
- Ribitol 5-phosphate transferase FKRP
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- Protein O-mannosyl-transferase 1
- Protein O-mannosyl-transferase 2
- Protein O-mannose kinase
- D-ribitol-5-phosphate cytidylyltransferase
- Dystroglycan 1
- Ribitol-5-phosphate xylosyltransferase 1
- Xylosyl- and glucuronyltransferase LARGE1
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Sequence:
MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSTKNGAGLSKSKGSRIGFDSTQWRAVKKFIMLTSNQNVPVFLIDPLILELINKNFEQVKNTSHGSTSQCKFFCVPRDFTAFALQYHLWKNEEGWFRIAENMGFQCLKIESKDPRLDGIDSLSGTEIPLHYICKLATHAIHLVVFHERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLEVLIPKDPMHFVEEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKSAKELLQLAAKTLNKLGVPFWLSSGTCLGWYRQCNIIPYSKDVDLGIFIQDYKSDIILAFQDAGLPLKHKFGKVEDSLELSFQGKDDVKLDVFFFYEETDHMWNGGTQAKTGKKFKYLFPKFTLCWTEFVDMKVHVPCETLEYIEANYGKTWKIPVKTWDWKRSPPNVQPNGIWPISEWDEVIQLY