wanglab/gogpt-training-data huggingface dataset:
Protein: Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1) (Q8N448)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein numb homolog
- DNA-directed RNA polymerases I and III subunit RPAC2
- Numb-like protein
- Treacle protein
Sequence:
MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV
Protein: Homoserine O-acetyltransferase (HAT) (EC 2.3.1.31) (Homoserine transacetylase) (HTA) (Q8F4I0)
Organism: Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Function: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00296}.
Interaction partners:
- O-acetylhomoserine/O-acetylserine sulfhydrylase
- Methyltransferase
- Homoserine dehydrogenase
- Cystathionine gamma-synthase
- Serine hydroxymethyltransferase
- Tryptophan synthase beta chain
- Methionine synthase
- Phosphoserine phosphatase
- Tryptophan synthase alpha chain
- CDP-diacylglycerol--serine O-phosphatidyltransferase
Sequence:
MNETGSIGIIETKYAEFKELILNNGSVLSPVVIAYETYGTLSSSKNNAILICHALSGDAHAAGYHSGSDKKPGWWDDYIGPGKSFDTNQYFIICSNVIGGCKGSSGPLSIHPETSTPYGSRFPFVSIQDMVKAQKLLVESLGIEKLFCVAGGSMGGMQALEWSIAYPNSLSNCIVMASTAEHSAMQIAFNEVGRQAILSDPNWKNGLYDENSPRKGLALARMVGHITYLSDDKMREKFGRNPPRGNILSTDFAVGSYLIYQGESFVDRFDANSYIYVTKALDHYSLGKGKELTAALSNATCRFLVVSYSSDWLYPPAQSREIVKSLEAADKRVFYVELQSGEGHDSFLLKNPKQIEILKGFLENPN
Protein: Homeobox protein onecut (Q9NJB5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcriptional regulator. Binds and recognize ATTG sites.
Subcellular location: Nucleus.
Interaction partners:
- Inhibitory POU protein
- LD23102p
- Origin recognition complex subunit 3
Sequence:
MDSLNDIIDHQTFSQELVEDASEFITVGHHSERPSQSSQQPNSGQDLTMSMQDIISCPVKHRTCSASGSGSASGSDSVVMVIDALGQGNRQSAYQIVPQQLQQRNMPLPFGLLERDRQHMQHGREVNTSPVDFVSSDINLDGLTVDADVSQTDHSQETAVKQEQKLLIVQSKSQDQSHRRIRMLVDVSSVNSGLGVHVDDMDEISSDGVGCDDEGVTLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRSTHSEMGLDNGHGEVLSVIVHSQDSDKEDCEENDDGDAEGDLENEDDDERDSRSREQLLSHSSYQTLTSVNDRLSSPGFSQTSYATLTPIQPLPPISTMSEKFAYSGHISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCSSFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSLSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKEEPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWRDDDSKSTMHVAHSRQQQDEQQKDNAHTHSQSQIQDQNHSQNQAIHNSMSQDPYSNLHTTAMSPLGAFDEDADMDLELESHDFDLVDPDEHGDTNDPNGDML
Protein: At3g10120 (Q8GY70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- D-ribose-binding periplasmic protein
- Uncharacterized protein At5g66580
- At3g03280
- Uncharacterized protein At5g17350
- HTH-type transcriptional regulator
- 6,7-dimethyl-8-ribityllumazine synthase
- 6,7-dimethyl-8-ribityllumazine synthase
- Uncharacterized protein At3g50800
- HTH-type transcriptional regulator
- At1g21010
Sequence:
MGNCLVMEKKVIKIMRNDGKVVEYRGPMKVHHILTQFSPHYSLFDSLTNNCHLHPQAKLLCGRLYYLLPQETNSIKHMKKTMKKVRFANPEVEKEEQEEDRLTDCCDNTKEKTNGVVRVKMVVSKQELEKLLQGGSVHEMVYRTLAKQHLCDDDDECHKEGWRPLLDSIPETD
Protein: Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PsmB) (P28061)
Organism: Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
Interaction partners:
- Proteasome subunit alpha
- JAB domain-containing protein
- ATP:glycerol 3-phosphotransferase
- Uncharacterized protein
- VCP-like ATPase
- VAT-2 protein
Sequence:
MNQTLETGTTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTYTGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVATLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSVEDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAISAAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLGLIL
Protein: Pentatricopeptide repeat-containing protein ATP4, chloroplastic (ATP synthase 4) (B4F8Z1)
Organism: Zea mays (Maize)
Function: Involved in translation and accumulation of chloroplast ATP synthase subunits. Interacts with the 5'-UTR of the chloroplast bicistronic atpB and atpE mRNA and activates its translation by facilitating ribosome association with the mRNA. Required for accumulation and activity of the chloroplast ATP synthase. Enhances atpA translation and is required for accumulation of specific processed atpF and psaJ transcripts. Required for the stabilization of bicistronic rpl16 and rpl14 mRNAs.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:22708543}.
Interaction partners:
Sequence:
MASLPLCRSPSSLLPSWPHRPISASFNPKNPSSPVAAHVSVQETPPQPQDPSPPSDSNPNGTRPSSSSNTRFLWVNPNSPRAADVARARAGSGRRARLASAAAALGACETTESAVEAALQAAFPEPPSEQDAVIVLNTAAATRAETAVLALRWFLGNAKVRKKVILYNVVLKLLRKKRLWSETEALWAEMLRDGVQPDNATFSTVISCARACGLHSKAVEWFDKMPEFGCSPDMLTYSAVIDAYGHAGNSEAALRLYDRARAEKWQLDPVICSTVIKVHSTSGNFDGALNVFEEMKAIGVRPNLVVYNTMLDAMGRALRPWVVKTIHREMVDQQVQPSRATYCCLLHAYTRARYGEDAMAVYRLMKDEAMGIDVMLYNMLLSMCADIGYVDEAEEIFRDMKASMGAHSKPDSWSYSSMVTLYSSTANVLSAEGILNEMVEAGFKPNIFVLTSLIRCYGKVGRTDDVVRSFGMLQDLGIIPDDRFCGCLLSVAANTPAEELGKVISCIERSNVQLGAVVKLLVDRSSSESFREAARELLRSSRGVVKMPYCNCLMDLCVNLNQMEKACALLDAAQQLGIYANIQTRTQTQWSLHLRGLSVGAALTTLHVWMNDLYTSLQTGNEGLPPLLGIHTGQGKNTYSDRGLAAMFEAHLKELDAPFHEAPDKAGWFLTTNVAAKQWLESKAASELVTV
Protein: GCN5-related N-acetyltransferase 8 (EC 2.3.1.48) (Probable acetyltransferase NATA1-like) (Q9ZV06)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32633465}. Nucleus {ECO:0000269|PubMed:32633465}.
Interaction partners:
- GCN5-related N-acetyltransferase 5, chloroplastic
- Acyl-CoA N-acyltransferases
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 6, chloroplastic
- GCN5-related N-acetyltransferase 10, chloroplastic
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 7, chloroplastic
- GCN5-related N-acetyltransferase 1, chloroplastic
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Sequence:
MAAAAPPPPPTAAPEPNMVAPLISPIGHPMFSRIRLATPSDVPFIHKLIHQMAVFERLTHLFSATESGLASTLFTSRPFQSFTVFLLEVSRSPFPATITSSPSPDFTPFFKTHNLDLPIDDPESYNFSPDMLNDVVVAGFVLFFPNYSSFLSKPGFYIEDIFVREPYRRKGFGSMLLTAVAKQAVKMGYGRVEWVVLDWNVNAIKFYEQMGAQILQEWRVCRLTGDALEAFDQVNI
Protein: Potassium channel toxin alpha-KTx 3.6 (BmKTX) (Q9NII7)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR.
Subcellular location: Secreted {ECO:0000269|PubMed:20713119}.
Interaction partners:
Sequence:
MKVFFAVLITLFICSMIIGIHGVGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPKG
Protein: Hyastatin (C4NZN9)
Organism: Hyas araneus (Atlantic lyre crab) (Great spider crab)
Function: Antimicrobial peptide. Has strong antibacterial activity against the Gram-positive bacterium C.glutamicum (MIC=0.4 uM) and the Gram-negative bacterium E.coli (MIC=12.5 uM). Has weak antibacterial activity against the Gram-positive bacterium S.aureus (MIC>50 uM) and the Gram-negative bacterium P.aeruginosa (MIC>50 uM). Has antifungal activity against S.cerevisiae (MIC=12.5) and C.albicans (MIC=6.3 uM). Has weak antifungal activity against the mold B.cinerea. Presents chitin-binding activity.
Subcellular location: Cytoplasmic granule {ECO:0000250|UniProtKB:P81058}.
Interaction partners:
Sequence:
MRVLLILVSLAALAHAESFLKSKTGYQGVQTLPGFIGGSQPHLGGGIGGGRPFISQPNLGGGIGGGIGGGKPFIPQPNLGGGIGSTRPFPRPQYGDYGSRNSCNRQCPSTYGGRGICCRRWGSCCPTNYKG
Protein: BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6) (Q8NC69)
Organism: Homo sapiens (Human)
Function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
Subcellular location: Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:22573887}. Note=Colocalizes with ANK1 isoform Mu17 at the M line in differentiated skeletal muscle cells and heart. {ECO:0000269|PubMed:22573887}.
Interaction partners:
- Cullin-3
- NEDD8-conjugating enzyme Ubc12
Sequence:
MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD
Protein: Basic salivary proline-rich protein 3 (Parotid salivary glycoprotein G1) (Proline-rich protein G1) (Q04118)
Organism: Homo sapiens (Human)
Function: Acts as a receptor for the Gram-negative bacterium F.nucleatum.
Subcellular location: Secreted.
Interaction partners:
- Basic salivary proline-rich protein 4
- Basic salivary proline-rich protein 1
- Retinoblastoma-associated protein
- C4b-binding protein alpha chain
Sequence:
MLLILLSVALLALSSAQSLNEDVSQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNKPQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQGPPPPPQGGRPHRPPQGQPPQ
Protein: LexA repressor (EC 3.4.21.88) (Q8F663)
Organism: Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- Protein RecA
- DNA polymerase IV
- DNA repair protein RecN
- Carboxy-terminal processing protease
- Lipoprotein
- tRNA N6-adenosine threonylcarbamoyltransferase
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Heavy metal efflux pump
- Outer membrane TolC superfamily protein
Sequence:
MKDLTDKQQAVLAFITAIIKERGFPPTIREIGDEFGITAKGAYDHLKAIEKKGYLKTAKNQSRAIELIRQSPMESLPVQATSIPVIGQVAAGLPIFAEENIESYIPVPDEMAKGNVPMYALRVQGDSMIEVGINDGDIAIIEKRDIARNGEIVVALIEDEATLKVYYKEQDQIRLEARNPKYKPIKTKKATVMGKLIGLYRIY
Protein: COUP transcription factor 2 (COUP-TF2) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2) (Q90733)
Organism: Gallus gallus (Chicken)
Function: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development.
Subcellular location: Nucleus.
Interaction partners:
- Ovalbumin
- SRY-box 18
- Proteasome activator complex subunit 3
- Ephrin-B2
- Hes related family bHLH transcription factor with YRPW motif 2
- Delta-like protein
- Hes related family bHLH transcription factor with YRPW motif 1.
- Uncharacterized protein
Sequence:
MAMVVGAWRDPQDDVPGAQGTQPAPAPPVQGPPAGTPHTPQTPGPGGPPSTPAQSNAASQQSQGDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ
Protein: Zinc finger protein 594 (Zinc finger protein HZF18) (Q96JF6)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MKEWKSKMEISEEKKSARAASEKLQRQITQECELVETSNSEDRLLKHWVSPLKDAMRHLPSQESGIREMHIIPQKAIVGEIGHGCNEGEKILSAGESSHRYEVSGQNFKQKSGLTEHQKIHNINKTYECKECEKTFNRSSNLIIHQRIHTGNKPYVCNECGKDSNQSSNLIIHQRIHTGKKPYICHECGKDFNQSSNLVRHKQIHSGGNPYECKECGKAFKGSSNLVLHQRIHSRGKPYLCNKCGKAFSQSTDLIIHHRIHTGEKPYECYDCGQMFSQSSHLVPHQRIHTGEKPLKCNECEKAFRQHSHLTEHQRLHSGEKPYECHRCGKTFSGRTAFLKHQRLHAGEKIEECEKTFSKDEELREEQRIHQEEKAYWCNQCGRNFQGTSDLIRHQVTHTGEKPYECKECGKTFNQSSDLLRHHRIHSGEKPCVCSKCGKSFRGSSDLIRHHRVHTGEKPYECSECGKAFSQRSHLVTHQKIHTGEKPYQCTECGKAFRRRSLLIQHRRIHSGEKPYECKECGKLFIWRTAFLKHQSLHTGEKLECEKTFSQDEELRGEQKIHQEAKAYWCNQCGRAFQGSSDLIRHQVTHTREKPYECKECGKTFNQSSDLLRHHRIHSGEKPYVCNKCGKSFRGSSDLIKHHRIHTGEKPYECSECGKAFSQRSHLATHQKIHTGEKPYQCSECGNAFRRRSLLIQHRRLHSGEKPYECKECGKLFMWHTAFLKHQRLHAGEKLEECEKTFSKDEELRKEQRTHQEKKVYWCNQCSRTFQGSSDLIRHQVTHTREKPYECKECGKTQSELRPSETS
Protein: EP3-2 procyclin (Q581F3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MAPRSLYLLAILLFSANLFSGVGFAAAAEGPEDKGLTKGGKGGKGTKVSDDDTNGTDPDPDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPGAATLKSVALPFAIAAVGLVAAF
Protein: Proteasome regulatory ATPase subunit 4 (Q9NC97)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MQERQEEYASLSEREQLRQDVIAKTIRRNESRARVREVAKAMEASERELMRVVDQLSALMSIGHFVGEILHKVDEERFIVQSVSGARHLVGYKKSIKPEKLKIGTRVALEITTLTIVRVLPREVDPQVYNMQVMENEKNISFQEIGGLQEQMRQMREVVELPLTNPELFVRVGISPPKGVLLYGPPGTGKTLLAKAIASNVDAAFLKIVASSIVDKYIGESARVLREMFAFARDHEPCIIFIDEVDAIGGKRIEGSSSDREVQRTLMELLHQMDGFEKLGKVKVIMATNRPDTLDPALMRPGRLDRKIEIGLPNEAGRLDVLKIHASKITKQGDIDYDSIVKLSEGFNGADLRNVCTEAGMFALRAGRDYVINEDFNKATRKVADSKKLESAPHQYSEQ
Protein: Zinc finger protein 623 (O75123)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MILLSFVSDSNVGTGEKKVTEAWISEDENSHRTTSDRLTVMELPSPESEEVHEPRLGELLGNPEGQSLGSSPSQDRGCKQVTVTHWKIQTGETAQVCTKSGRNHILNSDLLLLQRELIEGEANPCDICGKTFTFNSDLVRHRISHAGEKPYTCDQCGKGFGQSSHLMEHQRIHTGERLYVCNVCGKDFIHYSGLIEHQRVHSGEKPFKCAQCGKAFCHSSDLIRHQRVHTRERPFECKECGKGFSQSSLLIRHQRIHTGERPYECNECGKSFIRSSSLIRHYQIHTEVKQYECKECGKAFRHRSDLIEHQRIHTGERPFECNECGKAFIRSSKLIQHQRIHTGERPYVCNECGKRFSQTSNFTQHQRIHTGEKLYECNECGKAFFLSSYLIRHQKIHTGERVYECKECGKAFLQKAHLTEHQKIHSGDRPFECKDCGKAFIQSSKLLLHQIIHTGEKPYVCSYCGKGFIQRSNFLQHQKIHTEEKLYECSQYGRDFNSTTNVKNNQRVHQEGLSLSKAPIHLGERSVDKGEHTGNL
Protein: Hairy/enhancer-of-split related with YRPW motif protein 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (mHRT1) (Q9WV93)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11486044, ECO:0000269|PubMed:11741889}.
Interaction partners:
- S-phase kinase-associated protein 1
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Cullin-1
- Hairy/enhancer-of-split related with YRPW motif-like protein
- Neurogenic locus notch homolog protein 1
- Recombining binding protein suppressor of hairless
- Runt-related transcription factor 2
- Protein jagged-1
- Neurogenic locus notch homolog protein 4
- Delta-like protein 4
Sequence:
MKRAHPDYSSSDSELDETIEVEKESADENGNLSSALCSMSPTTSSQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLLVRLVSHLNNYASQREAASGAHGGLGHIPWGSAFGHHPHIAHPLLLPQNGHGNAGTAASPTEPHHQGRLASAHPEAPALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFSSFHLLSPSTPTQAANLGKPYRPWGTEIGAF
Protein: Protein SPEAR4 (SPL-like, EAR-containing protein 4) (TCP interactor containing EAR motif protein 3) (Q9SHQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Adapter-like transcriptional repressor recruiting TPL/TPR coepressors to inhibit TCP transcription factors (By similarity). May be involved in leaf development.
Interaction partners:
- Protein SPEAR1
- Protein SPEAR3
- Homeobox-leucine zipper protein ATHB-21
- Homeobox-leucine zipper protein ATHB-53
- Homeobox-leucine zipper protein ATHB-40
- Transcription factor TCP18
- Metalloendopeptidase / zinc ion binding protein
Sequence:
MCSKTSSVSYGNREDDDNYSSLCPKKQKHNNGGKKRVPRRGPGVAELEKIRLGEQHISTAAPFTLHHPPSLEKSPTITDRTGLVYPFSSYFSAGSFPSDLIPPAPVFQRKHDSSLHYLPPMNLPKQGSGGFYQFIEPPSSQTSSLDNVTKFLDEEKISSAKRPWHFMADTAKCSVGPSTTISRDAKQTRSLDLRLKNHVQDSGTTIRNPITIDSPSSASPPTTIFANPSLGFPRFLQKEEDDHEIIQRKSGTNFPLNKKPFYSFLPANDQIIRDQDRSFSLRTERYDTVPDHGIDLRLKL
Protein: Chaperone SurA (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (EC 5.2.1.8) (Rotamase SurA) (Survival protein A) (P0ABZ6)
Organism: Escherichia coli (strain K12)
Function: Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis.
Subcellular location: Periplasm. Note=Is capable of associating with the outer membrane.
Interaction partners:
- Outer membrane protein assembly factor BamB
- Outer membrane protein assembly factor BamA
- Chaperone protein Skp
- LPS-assembly protein LptD
- Outer membrane protein assembly factor BamE
- Outer membrane protein assembly factor BamD
- Periplasmic serine endoprotease DegP
- Bis
- Thiol:disulfide interchange protein DsbA
- Ribosomal RNA small subunit methyltransferase A
Sequence:
MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQLPDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLDQMRSRLAYDGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATPDIFDPAFRDALTRLNKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRASAYVKILSN
Protein: Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form] (P16442)
Organism: Homo sapiens (Human)
Function: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:18513251}. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
- Alpha-
Sequence:
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
Protein: Peroxisomal biogenesis factor 8 (Peroxin-8) (Peroxisomal protein PAS6) (P53248)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for peroxisome assembly.
Subcellular location: Peroxisome matrix {ECO:0000305}.
Interaction partners:
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein PEX14
- Peroxisomal biogenesis factor 2
- Peroxisomal membrane protein PEX17
- Peroxisomal targeting signal receptor
- Peroxisomal membrane protein import receptor PEX19
- Peroxisomal membrane protein PMP27
- Peroxisomal ATPase PEX6
Sequence:
MFDHDVEYLITALSSETRIQYDQRLLDEIAANVVYYVPRVKSPDTLYRLVGALFRSQFIVQLPPLRLLHIVKDVFLWKLEVSEPTLPISKFYLVWNAVFESHRATWNLSQLMVLDGVLVTYPSFKQLNNAYFIDESSNKTALYYRNWKLQLFSPIWAQLWNTAIVRANLSIQHCLLIALALLFNQSNRSALLHGVDVSWNLVTEKLLDLLEEYVHGIVQPMEIFSTDSVLSTNLNHLASCLTSSITRSNEATLVNSVRKLERICRYLSDTVASLKEQQLDFKFQNVFILIILALKELSAMNMTILPNHKDTFYSMICLSLFHVHVLTQKIGTVGFPSYDYVYDNLVTYFIVMDDLSKITTVLELMKRNNTKQDPNKLVFYINFLNKITNYYGCRIRLPFITEFIEPLLHFDVFFSGKTGNTLDIEIKESIHTLTITVLSIDSSYSSQVAQWQVSRILVYLKMSMDQFIAGKLSANQILLIFGHLSTQLPSLHNYNKHLLRDSLHETYIRIVNVKNPEKKNVLIECLIVQIAFINNPHHLIGWLNICLQLINTHNKKLLQQLWEMVSSLESSLAIDWWYTTVLSSQSSKL