wanglab/gogpt-training-data huggingface dataset:
Protein: RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) (Q9NYV6)
Organism: Homo sapiens (Human)
Function: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11250903}.
Interaction partners:
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase I subunit RPA1
- DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerase I subunit RPA43
- DNA-directed RNA polymerase I subunit RPA49
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA polymerase iota
- DNA-directed RNA polymerase I subunit RPA34
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MAAPLLHTRLPGDAAASSSAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLLDPDIKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDDNLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVNASRQGIEDAEETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLDQMVHPVAERLDILMSLVLSYMKDVCYVDGKVDNGKTKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRQMLPVIRSTAGGDSVQICTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMSAEELQEFKKPMKKDIVEDEDDDFLKGEVPQNDTVIGITPSSFDTHFRSPSSSVGSPPVLYMQPSPL
Protein: Oxidoreductase-like protein (Q384P1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDGDEGKSLPQEVAGEEMTLAAREARWGFTLDELHAATKVVRTLFHDPSLFVGDPYLHESRLYTMITRDRKTKRENRDVYKAIMNEEKSYRKRYKRMQDIEAIRRTEMKREREEALCLLQHQENEGSDRVVSLIRDRVSGPADTVDGQGARRSEDCHDGLSTHDRQIISQIGAFENIIRLEAMYTAGSAAMDWATASHLVAQVYRYLPHSFGTQMPPVLIGGSAPPGTDLLQQEMYTATIKLRIARLCGELFTLGGDDDNDDENMNGISGGSNNRDCGGKKAGELVSGIPSDEDIVVADSGAMRDLTCLRNCGTLDRASVDVVKALKHNLPVTDALHVFERAVSRGEPIDLFVTNDSVGTLTSPDAKAGGNGSGVQWSVDASLNLFIARRLYSKRRYRELGESPSDFPTRPPVSDDEEPDSFSVFQDIQQYAAGRPIPCDEALQLSRTIACHTCRVRYDKLHPYYYSMCHLCGEYNFNKRLMTRDLRGKVVLLTGCRIKIGFAMALSLLRCGAELIGTTRFAHEAVARFQREADYCVWAHRLHLFSLDLRDMWLVTQFCAFVMQKFGKLFAIINNAAQTIARTREYTKHLRHVESHPPLDLHKTLYDDAASREWHQYFLSHSSVTIGEPLHIEHHPQRQPFLDERITTGDATAYYNTNATGHSGVLVAIARSPLVVGSSKSSVFDRYDTAAEESDHRVTNSWVMKLAEVQGSEAAEVMAINALSPFIINSKLKPALLNRTGDPVTDEARFIINVSAMEGQFYRFKQVTHPHTNMAKAALNMMTRTSGEDYAQDGIYMNSVDTGWITDESPKAKKERRADQHQLCPLDEVDAAARCLDLIYSDRKVYGKFFKDFREIPW
Protein: Limbin (Q8K1G2)
Organism: Mus musculus (Mouse)
Function: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21356043}; Single-pass type I membrane protein {ECO:0000269|PubMed:21356043}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21356043}. Cell projection, cilium {ECO:0000269|PubMed:21356043}. Cell projection, cilium membrane {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}. Nucleus {ECO:0000269|PubMed:21356043}. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). {ECO:0000269|PubMed:24582806}.
Interaction partners:
- EvC complex member EVC
- Protein smoothened
- Suppressor of fused homolog
- EF-hand calcium-binding domain-containing protein 7
- IQ domain-containing protein E
- G-protein coupled receptor 161
Sequence:
MGATGPTGAGGRATWVLAGNILAAALVLGSGPRALPPSFPALGPGSPSRPGPAGPWASSQYSDISREARGPFENGVIFQKCSLVSGQSESQTMHVQLSVNNTRTPTSVNLSNLLVLDEITGLAVKESPGNNTQDGIQTFRKSFLQVGECYSVSYTASLDPTALGTGESLDLPARLIFQSPSQNRTQLKAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALFFLARGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQADADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQREMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQSTAMTQELLKRSAPWLFLQQILEEHSRESAARTTQLEAEERERGQELVQGVRQRLQQDALEAYTEEQAELRHWEHLVFMKLCCAAISLSEEDLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLSVYTALLSIQDLLLGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREEWQNGAVLEDSLESIEADTMASLCSQGLRLVSYLSRMTMVPGSTLLRLLSVVLPAASQPQLLALLDAVSEKHSDHTAENESSGEQAQAEQSKRRKHQVWWKVLDSRFRADLVSQGLERMLWARQKKERILKKIYVPVQERVMFPGKGSWPHLSLEPIGELAPIPITGADAMDILNTGEKIFVFRSPREPEISLRVPPRRKKNFLNAKKANRALGLD
Protein: Frizzled-2 (G5ECQ2)
Organism: Caenorhabditis elegans
Function: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to involve interactions with G-proteins (Probable). Required for the migration and axon formation and guidance of different neuronal cell types including canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right Q neuroblast (QR) and its descendants. Directs ALM migration through frizzled protein mom-5 and Wnt ligands cwn-1, cwn-2 and egl-20. May act redundantly with mom-5 to direct CAN migration. Plays a role in the organization of head ganglion cells. Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring and may in addition positively regulate the neurite outgrowth of RME GABAergic motor neurons along the anterior-posterior axis of the body.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein Wnt-1
- Protein Wnt
- Protein mom-2
- Protein Wnt-2
- DiSHevelled related
- Inactive tyrosine-protein kinase RYK
- DiSHevelled related
- Abnormal cell lineage protein 44
- Secreted frizzled-related protein 1
- Tyrosine-protein kinase receptor cam-1
Sequence:
MLLRISVLFLLLGSCGALFGKRQKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQENYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMSTGNICAAPPDTPKKQHKGHHHKNQNQNQNQNHNYSPDGPEVGISKIDNEVIAGPSECQCTCNQPFQFVASEKSKVGNVTNCAYSCHSPALAESHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMVAVGFMIRYFVGHEEIACDSMRIKGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASKWSPEAISSFSFHFHVVGWCLPAIQTVLVIVFNAIDGDPITGICYVGNTDLQFQRIFVLFPLLVYFIVGVLFLVIGFCNLWSIRNEVQKQHPSLESAHKITQLMSKIGIFSLLYTIPSLLIICVLFYEQNHRSLWEQSQLCSCSPKQTIGDSSLIISLIKTCCMCILGWTSGFWVCSTKTLSSWKNAICCLGSSRSLPKYQPADILYAKSDMSSSQFYNTSLRHNHLYGGIPDKL
Protein: Uncharacterized protein C3G9.05 (O42869)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Barrier septum {ECO:0000269|PubMed:16823372}. Cell tip {ECO:0000269|PubMed:16823372}. Note=Localizes at the barrier septum and the cell tip.
Interaction partners:
- Actin-interacting protein 3 homolog
- Cell division control protein 42 homolog
- Uncharacterized protein C16E8.08
- Actin
- GTP-binding protein rho1
- cytokinesis protein 3
- Sphingoid long chain base kinase 4
- Ingression protein fic1
- NADP-specific glutamate dehydrogenase
- Probable NAD-specific glutamate dehydrogenase
Sequence:
MQSIIIRQYRFLARYLEPEFVKDPALRNANARPREKLQRLSHIQFSELLTDVADELQRRINNDPKVRFLPPVDSYHPKRNHARQKLSSLAPTRLRDLCMDVFFEVQSRYSGALKEVSSNTPPNMTRAASQPPPQVQRLPASAPKHDLYSSANASSASLHPTEQRTTSSPTIPSYANRTHTDSPTSLSHRLPNVPDTNALNTVQANNSSTSSLSQGAQTGIDSSSNYLSRIEMLESSLAKSNSLLDSSKSEMEALKAKSISDATKHKNEIFQLEEKLHEASHEAEISIKKLNDAENRIKELENNPTLSFNPELEKNLKLMQELIVAESSKTQHIVELESCIDSLKAETERWKKVAINAKSAKIDEDIRLFTMTTVPMKSIRELISPNGFLDEQLYIRYFVEMNVFVASLRRDSPSQWMSTAKDIALTLEAIVSSLREKSLLEELPDLGKKVDDLCSFTNSLMEQVRLAVINGALLPIYHVDASACSISISLMDIAKTYGLTNTGKSSLSVGRNSLHPVDDLKALSVAKTLLSEKSKQFSETNQKLLDAISSDSSSSTIQQRVHEDINVIRDTLFDVSSPLELMRDRAAYAVIHNALQEMRRYCMQLIEQEGHGENFGFTDNNSVPPLTDLAFSAAKCFKDILRAIEDAEFSVQRTQFSTR
Protein: Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18) (P61216)
Organism: Mus musculus (Mouse)
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15543}.
Interaction partners:
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 1
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 3
- Transcription initiation factor TFIID subunit 5
Sequence:
MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS
Protein: Meiosis-specific protein ASY3 (Protein ASYNAPTIC 3) (AtASY3) (Q0WR66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for normal meiosis in male and female gametophytes. Acts with ASY1 at the interface between the developing chromosome axes and the recombination machinery to ensure interhomolog recombination. Required for synaptonemal complex formation during meiosis.
Subcellular location: Chromosome {ECO:0000269|PubMed:22319460}. Nucleus {ECO:0000269|PubMed:22319460}. Note=During interphase-early leptotene, distributed as numerous punctuate foci throughout the chromatin. At zygotene and pachytene, shows a continuous localization along chromosomal axes. {ECO:0000269|PubMed:22319460}.
Interaction partners:
- Meiosis-specific protein ASY1
- Synaptonemal complex protein 2
- Synaptonemal complex protein 1
- Putative recombination initiation defects 3
- Hsp70-Hsp90 organizing protein 1
- Meiotic recombination protein DMC1 homolog
- Meiotic recombination protein SPO11-1
- E3 ubiquitin-protein ligase CCNB1IP1 homolog
- DNA mismatch repair protein MSH4
- DNA mismatch repair protein MLH1
Sequence:
MSDYRSFGSNYHPSSQSRKISIGVMADSQPKRNLVPDKDDGDVIARVEKLKSATVTELQANKKEKSDLAAKQRNSAQVTGHVTSPWRSPRSSHRKLGTLESVLCKQTSSLSGSKGLNKGLNGAHQTPARESFQNCPISSPQHSLGELNGGRNDRVMDRSPERMEEPPSAVLQQKVASQREKMDKPGKETNGTTDVLRSKLWEILGKASPANNEDVNSETPEVEKTNFKLSQDKGSNDDPLIKPRHNSDSIETDSESPENATRRPVTRSLLQRRVGAKGVQKKTKAGANLGRKCTEQVNSVFSFEEGLRGKIGTAVNSSVMPKKQRGRRKNTVVKCRKAHSRKKDEADWSRKEASKSNTPPRSESTETGKRSSSSDKKGSSHDLHPQSKARKQKPDISTREGDFHPSPEAEAAALPEMSQGLSKNGDKHERPSNIFREKSVEPENEFQSPTFGYKAPISSPSPCCSPEASPLQPRNISPTLDETETPIFSFGTKKTSQGTTGQASDTEKRLPDFLEKKRDYSFRRESSPEPNEDLVLSDPSSDERDSDGSREDSPVLGHNISPEERETANWTNERSMLGPSSVKRNSNLKGIGRVVLSPPSPLSKGIDKTDSFQHCSEMDEDEDEGLGRAVALFAMALQNFERKLKSAAEKKSSEIIASVSEEIHLELENIKSHIITEAGKTSNLAKTKRKHAETRLQEQEEKMRMIHEKFKDDVSHHLEDFKSTIEELEANQSELKGSIKKQRTSHQKLIAHFEGGIETKLDDATKRIDSVNKSARGKMLQLKMIVAECLRDD
Protein: Corticotropin-releasing factor-binding protein (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP) (Q60571)
Organism: Mus musculus (Mouse)
Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Corticoliberin
- Urocortin
- Corticotropin-releasing factor receptor 1
- Corticotropin-releasing factor receptor 2
- Urocortin-3
- Urocortin-2
Sequence:
MSPNFKLQCHFILILLTALRGESRYLEVQEAAVYDPLLLFSANLKRDLAEEQPYRRALRCLDMLSLPGQFTFTADRPQLHCAAFFIGEPEEFITIHYDLVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPTMKRYTDFCESGLTRRSIRSSQNVAMVFFRVHEPGNGFTITIKTDPNLFPCNVISQTPSGRFTLVVPYQHQNCSFSIIYPVAIKISDLTLGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDPSKMMPLADLCYPFLGPAQMKISCDNAVVRMVSSGKHINRVTFEYRQLEPFELETSTGNSIPEYCLSSL
Protein: 26S proteasome regulatory subunit 7 homolog A (26S proteasome AAA-ATPase subunit RPT1a) (26S proteasome subunit 7 homolog A) (Regulatory particle triple-A ATPase subunit 1a) (Q9SSB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- Proteasome subunit alpha type-3
- 26S proteasome non-ATPase regulatory subunit 13 homolog B
- 26S proteasome non-ATPase regulatory subunit 13 homolog A
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit RPN13
- Proteasome subunit beta type-4
Sequence:
MVRDIEDEIRDEKNPRPLDEDDIALLKTYGLGPYSAPIKKVEKEIKDLAKKINDLCGIKESDTGLAPPSQWDLVSDKQMMQEEQPLQVARCTKIISPNTEDAKYVINVKQIAKFVVGLGDKVSPTDIEEGMRVGVDRNKYQIQIPLPPKIDPSVTMMTVEEKPDVTYNDVGGCKEQIEKMREVVELPMLHPEKFVKLGIDPPKGVLCYGPPGTGKTLLARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFQMARSKKACIVFFDEVDAIGGARFDDGVGGDNEVQRTMLEIVNQLDGFDARGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLESRTQIFKIHTRTMNCERDIRFELLARLCPNSTGADIRSVCTEAGMYAIRARRKTVTEKDFLDAVNKVIKGYQKFSATPKYMVYN
Protein: E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) (Q8ND25)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Subcellular location: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 N
- Ubiquitin-conjugating enzyme E2 D2
- E2 ubiquitin-conjugating enzyme
Sequence:
MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD
Protein: Dynein regulatory complex subunit 2 (Q384U1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000256|ARBA:ARBA00004611}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000256|ARBA:ARBA00037841}.
Interaction partners:
- Uncharacterized protein
- Dynein arm light chain, axonemal, putative
Sequence:
MQADAKGKKKKGSKKRRTLDPVVAERMRVEEEERRRRQEVALVERLREMKNEEETMTKNATAVVEARWISFLRECKRKELVAEIEIVRRAFGSSVDRKNAVIDMLFDELVDAEEQHRLVFQSHMRTVDSLIQMQSTRMEDLEGEFEKDLQEMKADYDRELLELARKHEYEVADLTFILENMAEEAEQLEKKLQENTSEAHDTALEKMEEDRKQMEAELIRASEAIRSELDTRYKEFMATAQVSMKDYMDKSKKDAETTQRIASQTQRIEKLQESVNSWRTNIARNAKGWEQKNSVIQQERDATIGHLKALKSKMHGWRSKEASRLAEVIKSAKDVEDKLRGVVKDAEKILRLVELAKPLETDREQILSCNSNITTSEIEKEVKHLIANTDAGRPSEESSVPDGAAFSEDWRLLERFWTKYNKVVLDNVALSQERRHLEEENLKLQVLLKQYLDEISLNDAVIRGPNPLIQASKLLTVVEAAGRGATGGRREYTTAIEGNKFVSDMTR
Protein: Piwi-like protein 3 (Q7Z3Z3)
Organism: Homo sapiens (Human)
Function: May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q9JMB7}.
Interaction partners:
- Endoribonuclease Dicer
- Tudor domain-containing protein 15
- Tudor domain-containing protein 1
Sequence:
MPGRARTRARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRVEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLKGHLQSVTAPMGITMKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL
Protein: Probable polypeptide N-acetylgalactosaminyltransferase 8 (EC 2.4.1.41) (Polypeptide GalNAc transferase 8) (GalNAc-T8) (pp-GaNTase 8) (Protein-UDP acetylgalactosaminyltransferase 8) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8) (Q9NY28)
Organism: Homo sapiens (Human)
Function: Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9HCQ5}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Beta-1,4 N-acetylgalactosaminyltransferase 1
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
- C1GALT1-specific chaperone 1-like protein
Sequence:
MMFWRKLPKALFIGLTLAIAVNLLLVFSSKGTLQNLFTGGLHRELPLHLNKRYGAVIKRLSHLEVELQDLKESMKLALRQQENVNSTLKRAKDEVRPLLKAMETKVNETKKHKTQMKLFPHSQLFRQWGEDLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVDGFNWELWCRYDALPQAWIDLHDVTAPVKSPSIMGILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYALDLTAALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYPLLKPLHTIVGYGRMKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMKKDLLGSHVLVLQTCSTQVWEIQHTVRDWGQTNSQ
Protein: Transcription factor RFX4 (Regulatory factor X 4) (Q7TNK1)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858, ECO:0000269|PubMed:14701801, ECO:0000269|PubMed:18218630}.
Interaction partners:
Sequence:
MHCGLLEEPDMDSTESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKREVTKQTVAYSPRSKLGTLLPDFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLSSITKQTLYTMEDSRDEHRRLIIQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEAQEEIILTEATPPTPSPGPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTAGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRSTHMPSSSVTHRIPVYSHREEHGYTGSYNYGSYGNQHPHPLQNQYPALPHDTAISGPLHYSPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPTANACYTSPSVHSTRYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (A0A3B3IU06)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGVKKTSVLPSERKVGGPETQERALLVQDEEKIKRQERSTERALPQQENEEILPKVSIPIPEDHKSLKKCHLYFSTFPSPRIPFMMSFLVILVLAVWWLVFL
Protein: Aryl hydrocarbon receptor nuclear translocator (O43392)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPA