wanglab/gogpt-training-data huggingface dataset:
Protein: Nanos homolog 3 (Q90WW1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein which binds to RNA with no sequence specificity. Probably represses translation of specific mRNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival but is not required for PGC specification. Also required to maintain oocyte production in the adult ovary. Negatively regulates phosphorylation of myosin mylpfa/mylz2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11691838}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11691838}.
Interaction partners:
- Dead end protein 1
- Deleted in azoospermia-like
- Tudor domain-containing protein 7A
- Piwi-like protein 1
- PR domain zinc finger protein 14 isoform X1
- Bucky ball
- Pumilio RNA-binding family member 2.
- Piwi-like protein 2
- Carbonic anhydrase
- RNA binding protein
Sequence:
MAFSLLQFILSAHGSMETRNQDFQPWKDYMGLADMIRGMKRQEMQSDADSDEQAAALLESPSGPIRSRDSPEQNTSPGGGKPKSSPAERKFCSFCKHNGETEAVYTSHYLKNRDGDVMCPYLRQYKCPLCGATGAKAHTKRFCPMVDKNYCSVYAKSTW
Protein: Auxin efflux carrier component 4 (AtPIN4) (Q8RWZ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a component of the auxin efflux carrier. Plays a role in generating a sink for auxin into columella cells. Maintains the endogenous auxin gradient, which is essential for correct root patterning. Involved in EXO70A3-regulated gravitropic responses in columella cells and in root system architecture (RSA).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20439545, ECO:0000269|PubMed:31299202}; Multi-pass membrane protein {ECO:0000305}. Note=Distribution in columella cells is regulated by EXO70A3. {ECO:0000269|PubMed:31299202}.
Interaction partners:
- Auxin transporter protein 1
- Auxin transporter-like protein 3
- Auxin transporter-like protein 2
- Serine/threonine-protein kinase D6PK
- Protein TRANSPORT INHIBITOR RESPONSE 1
- ABC transporter B family member 19
- Auxin transporter-like protein 1
- ABC transporter B family member 1
- L-tryptophan--pyruvate aminotransferase 1
- Serine/threonine-protein kinase WAG2
Sequence:
MITWHDLYTVLTAVVPLYVAMILAYGSVQWWKIFSPDQCSGINRFVAIFAVPLLSFHFISTNDPYAMNFRFVAADTLQKIIMLVLLALWANLTKNGSLEWMITIFSLSTLPNTLVMGIPLLIAMYGTYAGSLMVQVVVLQCIIWYTLLLFLFEYRGAKLLIMEQFPETGASIVSFKVESDVVSLDGHDFLETDAEIGNDGKLHVTVRKSNASRRSLMMTPRPSNLTGAEIYSLSSTPRGSNFNHSDFYSVMGFPGGRLSNFGPADLYSVQSSRGPTPRPSNFEENNAVKYGFYNNTNSSVPAAGSYPAPNPEFSTGTGVSTKPNKIPKENQQQLQEKDSKASHDAKELHMFVWSSSASPVSDVFGGGAGDNVATEQSEQGAKEIRMVVSDQPRKSNARGGGDDIGGLDSGEGEREIEKATAGLNKMGSNSTAELEAAGGDGGGNNGTHMPPTSVMTRLILIMVWRKLIRNPNTYSSLIGLIWALVAYRWHVAMPKILQQSISILSDAGLGMAMFSLGLFMALQPKIIACGNSVATFAMAVRFITGPAIMAVAGIAIGLHGDLLRIAIVQAALPQGIVPFVFAKEYNVHPTILSTGVIFGMLIALPITLVYYILLGL
Protein: Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) (Prohormone convertase 3) (P23377)
Organism: Rattus norvegicus (Rat)
Function: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P09958}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P09958}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000250|UniProtKB:Q28193}. Endosome membrane {ECO:0000250|UniProtKB:P09958}; Single-pass type I membrane protein {ECO:0000305}. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin. {ECO:0000250|UniProtKB:P09958}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transmembrane protease serine 2
- Stromelysin-3
- Prothrombin
- Fibrillin-1
- Vitamin K-dependent protein C
- Angiotensin-converting enzyme 2
- Fibrillin-2
- Matrix metalloproteinase-14
- Zona pellucida sperm-binding protein 2
Sequence:
MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQRVPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
Protein: Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) (Q9WVB9)
Organism: Rattus norvegicus (Rat)
Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
Interaction partners:
- Vang-like protein 2
- Glycogen synthase kinase-3 beta
- Prickle-like protein 1
- Axin-2
- Vang-like protein
- Dishevelled associated activator of morphogenesis 1
- Prickle planar cell polarity protein 2
- Inversin
- Prickle planar cell polarity protein 4
- Prickle homolog 3
Sequence:
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRELGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLIRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
Protein: Solute carrier family 22 member 2 (Zgc:64076) (Q7T2C0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MTTFEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWSLQDARRATVPLINGSSGASYSQCGRFDVDWNATGLSCENPDGDFNQSQLSVMPMMSCVDGWEYDYVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNFFIGVTGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQLFFSMGILLLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTLSKKIETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGGNVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDSMFWLKSAVACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALAFVAGGLVLLLPETKGVPLPETIDDIEHPNRNKENPQQSQQLENLMTSDVTKNKDVTAV
Protein: 25S rRNA (adenine(645)-N(1))-methyltransferase (EC 2.1.1.287) (Ribosomal RNA-processing protein 8) (P38961)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 645 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Also involved in telomere length regulation and maintenance.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10864042, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:23180764}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
- Importin subunit beta-1
- Importin subunit alpha
- Essential nuclear protein 1
- KRR1 small subunit processome component
- Nucleolar GTP-binding protein 1
- Ribosomal RNA small subunit methyltransferase NEP1
- Nucleolar complex protein 2
- ATP-dependent RNA helicase ROK1
- Ribosome biogenesis protein MAK21
- Nucleolar complex protein 14
Sequence:
MALFNVEGWSIKTKTVAFDNKTNKSSKDKKKNNRKNGKLTREQKLKEETEAELKEQVEDIPSEGSVAKDIPKKNQEKSDQNETSKKRKHDEEAPLMQVKENIEKPTKKQLTPLQQKMMAKLTGSRFRWINEQLYTISSDEALKLIKEQPQLFDEYHDGFRSQVQAWPENPVDVFVDQIRYRCMKPVNAPGGLPGLKDSKEIVIADMGCGEAQLALEINNFFKNYNKKAKKYLKRRHKVHSFDLKKANERITVADIRNVPLPDESCTIVVFCLALMGTNFLDFIKEAYRILAPRGELWIAEIKSRFSDGKGNEFVDALKLMGFFHKKTFDENKMFTRFEFFKPPAEIIEERRQKLERRQKFIEVETEKEELEKKRRKIAEGKWLLKPCIYKRR
Protein: Probable mitochondrial-processing peptidase subunit alpha-2, chloroplastic/mitochondrial (Alpha-MPP 2) (Complex III subunit II) (Core protein II) (Cytochrome b-c1 complex subunit 2-2, mitochondrial) (Inactive zinc metalloprotease alpha-2) (Ubiquinol-cytochrome c oxidoreductase core protein 2-2) (O04308)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:22131051}. Mitochondrion matrix {ECO:0000269|PubMed:22131051}. Mitochondrion inner membrane {ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:22131051}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07257}; Matrix side {ECO:0000250|UniProtKB:P07257}.
Interaction partners:
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c1 1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 7-1, mitochondrial
- Probable mitochondrial-processing peptidase subunit beta, mitochondrial
- Cytochrome c1 2, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-1, mitochondrial
- Cytochrome b-c1 complex subunit 7-2, mitochondrial
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Cytochrome b-c1 complex subunit Rieske-2, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MYRTAASRAKALKGILNHNFRASRYASSSAVATSSSSSSWLSGGYSSSLPSMNIPLAGVSLPPPLSDHVEPSKLKTTTLPNGLTIATEMSPNPAASIGLYVDCGSIYETPQFRGATHLLERMAFKSTLNRSHFRLVREIEAIGGNTSASASREQMGYTIDALKTYVPEMVEVLIDSVRNPAFLDWEVNEELRKVKVEIGEFATNPMGFLLEAVHSAGYSGALANPLYAPESAITGLTGEVLENFVFENYTASRMVLAASGVDHEELLKVVEPLLSDLPNVPRPAEPKSQYVGGDFRQHTGGEATHFALAFEVPGWNNEKEAIIATVLQMLMGGGGSFSAGGPGKGMHSWLYLRLLNQHQQFQSCTAFTSVFNNTGLFGIYGCTSPEFASQGIELVASEMNAVADGKVNQKHLDRAKAATKSAILMNLESRMIAAEDIGRQILTYGERKPVDQFLKTVDQLTLKDIADFTSKVITKPLTMATFGDVLNVPSYDSVSKRFR
Protein: DEAD-box ATP-dependent RNA helicase 56 (EC 3.6.4.13) (UAP56 homolog B) (Q9LFN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. In addition to ssRNA and dsRNA, binds dsDNA, but not ssDNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:23555998}. Note=Localizes predominantly to euchromatic regions of the nucleoplasm.
Interaction partners:
- THO complex subunit 2
- Protein MODIFIER OF SNC1 11
- RNA-binding protein Y14
- ATP-dependent RNA helicase DEAH12, chloroplastic
- THO complex subunit 3
- THO complex subunit 6
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH9
- THO complex subunit 4A
- THO complex subunit 4B
- THO complex subunit 4D
Sequence:
MGDARDNEAYEEELLDYEEEDEKVPDSGNKVNGEAVKKGYVGIHSSGFRDFLLKPELLRAIVDSGFEHPSEVQHECIPQAILGMDVICQAKSGMGKTAVFVLSTLQQIEPSPGQVSALVLCHTRELAYQICNEFVRFSTYLPDTKVSVFYGGVNIKIHKDLLKNECPHIVVGTPGRVLALAREKDLSLKNVRHFILDECDKMLESLDMRRDVQEIFKMTPHDKQVMMFSATLSKEIRPVCKKFMQDPMEIYVDDEAKLTLHGLVQHYIKLSEMEKNRKLNDLLDALDFNQVVIFVKSVSRAAELNKLLVECNFPSICIHSGMSQEERLTRYKSFKEGHKRILVATDLVGRGIDIERVNIVINYDMPDSADTYLHRVGRAGRFGTKGLAITFVASASDSEVLNQVQERFEVDIKELPEQIDTSTYMPS
Protein: Serine/threonine-protein kinase GRIK2 (EC 2.7.11.1) (Protein GEMINIVIRUS REP INTERACTING KINASE 2) (Protein GRIK2) (SnRK1-activating protein kinase 1) (AtSnAK1) (Q5HZ38)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activates SnRK1.1/KIN10 and SnRK1.2/KIN11 by phosphorylation of their activation-loop 'Thr-198' and 'Thr-176', respectively. Required for the regulation by SnRK1 kinases of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes.
Interaction partners:
- Serine/threonine-protein kinase-like protein At5g23170
- Mitochondrial fission protein ELM1
- PHD finger protein ALFIN-LIKE 1
Sequence:
MFRDSFLFARTIGCFGCFGSSGSRNQQSPKPYDDDTHSCDSDVTSTARGEEEEDEEEVEQKSRSKRSEEILKYRLDNGLICRHIPVRETNELIRGEDENGDKTINEYVRVCKIGSGSYGKVVLYRSTLDGQYYAIKAFHKSHLLRLRVAPSETAMSDVLREVMIMKILEHPNIVNLIEVIDDPETDHFYMVLEYVDGKWVYDGSGPPGALGEKTARKYLRDIVTGLMYLHAHDVIHGDIKPDNLLVTSSGTVKIGDFSVSQVFKDDDDQLRRSPGTPVFTAPECCLVSGITYSGRAADTWAVGVTLYCMILGQYPFLADTLQDTYDKIVNNPLIIPDGLNPLLRDLIEGLLCKDPSQRMTLKNVSEHPWVIGEDGHVPEYFCWCKRNAASKIEEGEANGISETSDPN
Protein: Splicing factor 45 (RNA-binding motif protein 17) (Q7PL82)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
Interaction partners:
Sequence:
MTPVVNLRSKRLADPEVTCFAPITTVVSKPLISGKALPSILERINRGDWDVADEYDPQRPNEYEKLKEKSNGSDKNRAGVSDREDRDDKEKDRKRGRVGRREFYRDEVSAPNLKLSGFGHRQNDDDMYLPSPGLVAKQGGATIAPPPSLQEMSIDSGCEATNTMPYSASSVAAKIMAKYGFKDGQGLGKSEQGMAIALQVEKTSKRGGRIIHEKDVFLPPLALSPPSIGSQIGTSPSHKAMPPPQMVDTAAESGDIGYSITEIMKSPSKVVLLRNMVGPGDVDEELEPEVKDECNTKYGEVNSVIIHESFGTVPEDAVKIFVEFRRIESAIKAVVDLNGRFFGGRQVRAGFYNYDKFKCFQLH
Protein: Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A) (P0AE06)
Organism: Escherichia coli (strain K12)
Function: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}. Note=An unlipidated version of this protein (directed to the periplasm by the OmpA signal sequence) functions normally.
Interaction partners:
- Outer membrane protein TolC
- Probable aminoglycoside efflux pump
- Multidrug efflux pump subunit AcrB
- Multidrug efflux pump accessory protein AcrZ
- Multidrug export protein AcrF
- Multidrug resistance protein MdtF
- Macrolide export ATP-binding/permease protein MacB
- HTH-type transcriptional regulator AcrR
- Multidrug export protein EmrA
- Multidrug resistance protein MdtB
Sequence:
MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS
Protein: Thiamine-monophosphate kinase (TMP kinase) (TP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16) (A3MTW6)
Organism: Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)
Function: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Interaction partners:
- Phosphomethylpyrimidine kinase
- Adenylate kinase
- Uncharacterized protein
- Nucleoside-triphosphatase THEP1
Sequence:
MSGFGGRGVDEKGFLRWLLGELGVEEDDVAYVDGLVVKVDGAAASTSRLPFQTWADFGWRNVAAAYSDVRVKFAEARLLLASVTAPDLGTAAEVVQGVREASQFFSLAYVGGDLNEGRDVVVDVVLVGWARARVGRAPRPGDVLVTIPQFGYTSLAYRFWQMGGAVVERGVEALKRPKPLWPLPPAECVTAAMDSSDGLGDVLWSMARGVDIVVKELPAPREVLEFAAERGLDVGEIVFNGGEEFLPVFAVRRDCPVESPYVSFAEVVPGEGRVWWRGEELKWRGWAYFRGWG
Protein: Tegument protein UL23 (F5HDM3)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the inhibition of host innate immune response by disrupting the interaction between NMI and STAT1. In turn, NMI-mediated transcription of interferon-gamma stimulated genes is inhibited.
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P16846}. Host cytoplasm {ECO:0000250|UniProtKB:P16846}.
Interaction partners:
Sequence:
MSVIKDCFLNLLDRWRPPKTSRPWKPGQRVALVWPKDRCLVIRRRWRLVRDEGRDAQRLASYLCCPEPLRFVGSICTYNFLKHKGDHNVPSELYLGASGAMYLWTDHIYSDSLTFVAESITEFLNIGLRRCNFITVPEELPHTASLRALAGCMHIHAFAQWRATYRGRLMVMGDYSVIRVSTIRLYDWSEINDWRVMVGSNHVEPLGWLVSPYDVINLFVDDCMRVFAANNQHVCIVADSLMEFVTRGMTRCHENGIYYGTRSMRKLNKPTCPYGVDHQLFDDA
Protein: Zinc finger protein 581 (Q9P0T4)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MLVLPSPCPQPLAFSSVETMEGPPRRTCRSPEPGPSSSIGSPQASSPPRPNHYLLIDTQGVPYTVLVDEESQREPGASGAPGQKKCYSCPVCSRVFEYMSYLQRHSITHSEVKPFECDICGKAFKRASHLARHHSIHLAGGGRPHGCPLCPRRFRDAGELAQHSRVHSGERPFQCPHCPRRFMEQNTLQKHTRWKHP
Protein: Interferon gamma (IFN-gamma) (P01581)
Organism: Rattus norvegicus (Rat)
Function: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01579}.
Interaction partners:
- Interferon gamma receptor 2
- Interferon gamma receptor 1
- Interleukin-1 beta
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-10
- Interferon alpha/beta receptor 1
- Interleukin-1 alpha
- Granulocyte colony-stimulating factor
Sequence:
MSATRRVLVLQLCLMALSGCYCQGTLIESLESLKNYFNSSSMDAMEGKSLLLDIWRNWQKDGNTKILESQIISFYLRLFEVLKDNQAISNNISVIESHLITNFFSNSKAKKDAFMSIAKFEVNNPQIQHKAVNELIRVIHQLSPESSLRKRKRSRC
Protein: anthranilate synthase (EC 4.1.3.27) (C8V7L2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Anthranilate phosphoribosyltransferase, hypothetical
- Multifunctional tryptophan biosynthesis protein
- tryptophan synthase
- Tryptophan synthase
- Chorismate synthase
- Chorismate mutase
- Aromatic-amino-acid transaminase, hypothetical
- aromatic-amino-acid transaminase
- aminodeoxychorismate synthase
Sequence:
MAPPITIVPSLETAKAAISQSKNSRFPPNLLPLTSSISADLLTPTLAYLRLAENSKLSFLYESAATTETIGRYSFVGADPHTVLKTGPGHGPESDPLPILEEKLANFRVASVPGLTLPPLTGGAIGYVGYDCVKYFEPKTARPLKDILGIPESLFMLFNTIVAFDHFYQVVKVVTYIPITDNDAELDANYKHGQAVIQRIIDTLQRPDTPLPPQGPIIQNQEYTSNIGREGYEGHVVKLKEHIAKGDIFQTVPSQRLSRPTSLHPFNLFRHLRTVNPSPYLFYIDCEDFQLVGASPELLAKEEKGRIITHPIAGTVKRGKTAEEDEALAEELRSSLKDRAEHVMLVDLARNDVNRVCDPLTTQVDRLMVVEKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMQLIAELEGEKRGVYAGAVGYFGYNIASADGSKEIPGAMDTCIALRTMLVKDGVAYLQAGGGIVFDSDPYDEYVETLNKLGANIACIKGAEEKYLSMEAKS
Protein: Phospholipid scramblase (A5WVT4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Solute carrier family 43 member 3 isoform X1
- Si:dkey-26i13.8
- Si:dkey-165a24.9
- Rho/rac guanine nucleotide exchange factor
- Beta-galactosidase
- Pleckstrin homology domain-containing, family N member 1.
- Anoctamin
- Musculoskeletal embryonic nuclear protein 1
Sequence:
METNNAGYPVELQPNKNAIHPAPGYGQGAAIPGHGQVVMMPVPQRPDGCPPGLEYLTQIDQLLVQQKVELAEVILGWETNNKYIVKNSMGQQVFYVAEENDCCNRQFCGPLRSFVIHVQDNLGQEVMRLMRPLKCGSCFCPCCLQELEIQSPPGYPIGYVIQNWHPFLPKFTIQNEKKEAVLKIEGPFCSCRCCSDVNFDVLSLDESTKVGKISKQWTGLVREAFTDADNFGISFPMDLDVKIKAVLFGACFLIDFMFFEHNK
Protein: Tetraspanin-32 (Tspan-32) (Protein Phemx) (Q96QS1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C11orf21
- U5 small nuclear ribonucleoprotein TSSC4
- CD151 antigen
- CD63 antigen
- CD9 antigen
- CD81 antigen
- Pleckstrin homology-like domain family A member 2
- Tetraspanin-9
Sequence:
MGPWSRVRVAKCQMLVTCFFILLLGLSVATMVTLTYFGAHFAVIRRASLEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAAATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAAREDCLQGIRSFLRTHQQVASSLTSIGLALTVSALLFSSFLWFAIRCGCSLDRKGKYTLTPRACGRQPQEPSLLRCSQGGPTHCLHSEAVAIGPRGCSGSLRWLQESDAAPLPLSCHLAAHRALQGRSRGGLSGCPERGLSD
Protein: Nuclear pore complex protein (A2RV69)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|RuleBase:RU365072}. Nucleus membrane {ECO:0000256|RuleBase:RU365072}.
Interaction partners:
- Uncharacterized protein
- Nuclear pore complex protein Nup155
- 54 kDa nucleoporin
- Nuclear pore glycoprotein p62
- Protein SEC13 homolog
- Nuclear pore complex protein Nup133
- Uncharacterized protein.
- Uncharacterized protein.
- Uncharacterized protein
- Nuclear pore complex protein Nup153
Sequence:
MDMLSPVVREAEVSRAARRQSSNRKNPADESWSNATPTRGPSSRTTGQTLFRQHMTPQTWNSSRPPDVSAILGTVGRSPRLLQTPGRLANLSMMSNPDDSVWTTTFSPGRTGMYTTLDSPSFTEDITLSAVMLQEEDPGEAATMSMYPDFLKSFLEHPSSAVFELIEQYEATCNTQITLLKKIVKRVTPGQQKFSKTASILWLLQQEMVTWRLIAALYRDRIQSALEEENMFEIAAPNASEKTIVDKLFQRDTLVRQSQLVVDWLESIAKDEVGDFSDNIEYYAKSVYWENTLHTLKQRSMLSLGSSRPLVSELDPDAPIRQKLPLDDLDREDDIRLLKYLFTLIRAGMTDEAQRLCKRCGQAWRAATLEGWKLYHDANINGGTELQAVEGNPYRCVWKTCCWRMAEDEQFNKYERAIYATLSGNLKQLLPVCESWEDTVWAHFKVMVDSLVEQEIRASIISFNEANELPREYLEANWTLDSVFEELQATDKKRVLEENREHYHIIQKFVILADVDGLMDEFSEWLSNGKNLLLGHLLRFMTHLLLFFRTLGLQAKEEVSVEVLKTYIQRLINEKQIELIAFYVSHLPQELAISQYAVFLENITDPDQRQRCLELAKEAGLDVASITKTVVENTRKKDAGEFAHHDFAPALDSGTSEEDRAKIDVIDWLVFDPAQRAEALKQSNAIMRKFLASKKHEAAKEVFAKIPQDSIAEIYSQWEEQAMDSALPAEDDNAIREHLCIRAYLESHEAFNEWFKHINSPPQKPTLVGQASFTEKVAHEHKEKKYEMDFGIWKGHLDALTSDVKEKIYNVLLFVDGGWMVDVREDTEEDPERSHQMVLLRRLCLPMMCFLLHTVLHNTKQYKDCLRLADIVSSENQKLYTVFSKTEMRNLLQKLRESSLMLLDLQLDPLGYEIQS