wanglab/gogpt-training-data huggingface dataset:
Protein: Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (EC 1.2.1.12) (NAD-dependent glyceraldehydephosphate dehydrogenase C subunit 2) (Q9FX54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. Together with DNA polymerase II subunit B3-1 (DPB3-1) and GAPC1, enhances heat tolerance and promotes the expression of heat-inducible genes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18298409, ECO:0000269|PubMed:32651385}. Nucleus {ECO:0000269|PubMed:18298409, ECO:0000269|PubMed:32651385}. Note=Accumulates in the nucleus under heat stress. {ECO:0000269|PubMed:32651385}.
Interaction partners:
- Triosephosphate isomerase, cytosolic
- Phosphoribulokinase, chloroplastic
- Triosephosphate isomerase, chloroplastic
- Phosphoglycerate kinase 3, cytosolic
- Phosphoglycerate kinase 1, chloroplastic
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- Phosphoglycerate kinase 2, chloroplastic
- Glucose-6-phosphate isomerase, cytosolic
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
Sequence:
MADKKIRIGINGFGRIGRLVARVVLQRDDVELVAVNDPFITTEYMTYMFKYDSVHGQWKHHELKVKDDKTLLFGEKPVTVFGIRNPEDIPWGEAGADFVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVVGVNEHEYKSDLDIVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHSITATQKTVDGPSMKDWRGGRAASFNIIPSSTGAAKAVGKVLPSLNGKLTGMSFRVPTVDVSVVDLTVRLEKAATYDEIKKAIKEESEGKMKGILGYTEDDVVSTDFVGDNRSSIFDAKAGIALSDKFVKLVSWYDNEWGYSSRVVDLIVHMSKA
Protein: Multifunctional dioxygenase ausE (EC 1.14.11.-) (Austinoid biosynthesis clusters protein E) (Q5AR34)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Multifunctional dioxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Interaction partners:
- Terpene cyclase ausL
- Cytochrome P450 monooxygenase ausG
- FAD-binding monooxygenase ausB
- FAD-binding monooxygenase ausC
Sequence:
MGSATPSRLQKFPATAPADEIYAAFKEDGCVIIEGFVPPDQMARFSQEIQPAMEKIQVQVTNDGNSNDRVKRFSKLVTTSPTFRHEILENDLMHELLQRVFSKPGEGMGYHFNDTMVIEVQPGAPAQRLHRDQELYPWWNSMGPDAPECLVNFFCAVTPFTVENGATRLVPGSNRWPELTLINATDCPQYGKIDSVPAIMQPGDCYMMSGKVIHGAGHNATLSDQRRALAFSTIRRELRPVQAFPLWIPMQIATELSPRTQAMFGFRSSTQHCDVDTVHFWGNDGKDIGEHLGLISSA
Protein: Large ribosomal subunit protein uL30 (50S ribosomal protein L30) (P0AG51)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein bS18
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS11
- Elongation factor G
- GTP pyrophosphokinase
- Large ribosomal subunit protein uL14
- DNA-directed RNA polymerase subunit alpha
- Alternative ribosome-rescue factor A
- Large ribosomal subunit protein uL15
Sequence:
MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE
Protein: Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) (Q6N075)
Organism: Homo sapiens (Human)
Function: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- UNC93-like protein MFSD11
- SPRY domain-containing protein 3
- Major facilitator superfamily domain-containing protein 3
Sequence:
MLVTAYLAFVGLLASCLGLELSRCRAKPPGRACSNPSFLRFQLDFYQVYFLALAADWLQAPYLYKLYQHYYFLEGQIAILYVCGLASTVLFGLVASSLVDWLGRKNSCVLFSLTYSLCCLTKLSQDYFVLLVGRALGGLSTALLFSAFEAWYIHEHVERHDFPAEWIPATFARAAFWNHVLAVVAGVAAEAVASWIGLGPVAPFVAAIPLLALAGALALRNWGENYDRQRAFSRTCAGGLRCLLSDRRVLLLGTIQALFESVIFIFVFLWTPVLDPHGAPLGIIFSSFMAASLLGSSLYRIATSKRYHLQPMHLLSLAVLIVVFSLFMLTFSTSPGQESPVESFIAFLLIELACGLYFPSMSFLRRKVIPETEQAGVLNWFRVPLHSLACLGLLVLHDSDRKTGTRNMFSICSAVMVMALLAVVGLFTVVRHDAELRVPSPTEEPYAPEL
Protein: Adropin (Energy homeostasis-associated protein) (Q8K1D8)
Organism: Mus musculus (Mouse)
Function: Involved in the regulation of glucose homeostasis and lipid metabolism.
Subcellular location: Secreted {ECO:0000269|PubMed:19041763}.
Interaction partners:
- Probable G-protein coupled receptor 19
Sequence:
MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSLSESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP
Protein: Remorin (pp34) (P93788)
Organism: Solanum tuberosum (Potato)
Function: Binds to both simple and complex galacturonides. May be involved in cell-to-cell signaling and molecular transport.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8989883}; Peripheral membrane protein {ECO:0000269|PubMed:8989883}.
Interaction partners:
- NTGP1
- Syntaxin
- Syntaxin
- Syntaxin
- Ca2+ antiporter/cation exchanger
- Chromosome structural maintenance protein
- Vesicle transport protein SEC20
- ATZW10
- Membrin
- Membrin
Sequence:
MAELEAKKVEIVDPAPPAPGPVEAPKEVVADEKAIVAPALPPPAEEKEKPDDSKALVVVETKAPEPADEKKEGSIDRDAVLARVATEKRVSLIKAWEESEKSKAENKAQKKVSAIGAWENSKKANLEAELKKMEEQLEKKKAEYTEKMKNKIALLHKEAEEKRAMIEAKRGEDLLKAEELAAKYRATGTAPKKILGIF
Protein: T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80) (P33681)
Organism: Homo sapiens (Human)
Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:38467718}; Single-pass type I membrane protein.
Interaction partners:
- Cytotoxic T-lymphocyte protein 4
- T-lymphocyte activation antigen CD86
- Programmed cell death 1 ligand 1
- T-cell-specific surface glycoprotein CD28
- Tumor necrosis factor receptor superfamily member 5
- Intercellular adhesion molecule 1
- Programmed cell death protein 1
- CD40 ligand
- Inducible T-cell costimulator
- Tumor necrosis factor receptor superfamily member 4
Sequence:
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Protein: FRQ-interacting RNA helicase (Probable ATP dependent RNA helicase) (Q873J5)
Organism: Neurospora crassa
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDDLFEVFEEQPRAQKKRKASPDVEMADGAAAAAPVANAAAAVTHPQAQAAPAPQKDNIDNNDNNNNNTTTSAVQPTIPNGDAAAAADDVQSPQSPHGLGDNKRRKKTDEAEPIMTDAFQTAESREVTGAQGFAPTEGESIVLSHNIQHQVALPPDLDYEYIPLSEHKPPAEPARTYSFKLDPFQALSVASIEREESVLVSAHTSAGKTVVAEYAIAQCLKKNQRVIYTSPIKALSNQKYRDFQAEFGDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDKIRGVVWEETIILLPDKVRYVFLSATIPNAFQFAEWIAKIHRQACHVVYTDFRPTPLQNYFFPAGGKGILLIVDEKGNFKENNFNQAMAMIEEKKGTDSNDWSAKQKGKGKNKKTNKGGEAADEKADIAKIIKMILKKNFQPVIVFNFSKRECEQMALASSSMKFNAPDEENMVNKVFENALASLSEDDKNLPQISNILPLLRKGIGVHHSGLLPILKETIEILFQEGLIKVLFATETFSIGLNMPARTVVFTQVTKWDGQQRRPLTSSEYIQMAGRAGRRGLDDRGIVIMMVDDKLEPETARAIVVGNQDKLNSAFHLGYNMVLNLLRIEAISPEYMLERCFFQFQNAASVPQLERELISLQQERDAIIIPDESIVKDYYGVRQQLEEYNKDMVFVIQHPQNCLGFFQEGRLIHIKSPSGVDYGWGVLIKHIQRQTPKNGQPPYPEQESYVLDVLLKVSGDFNPKTRGEGPMPEGIMPAGKDSKNARWEVVPCLLNCLRALGQLRVFLPKRLESADEKDGVGKAVDEISRRFPDGIPILDPMENMGINDDSFKKLLRKIEVLESRLVANPLHNSPLLVELWNQYSLKMQLGEQIKEKKKAIARAHSVAQLDELKSRKRVLRRLGFINDAEVVQMKARVACEISSTEGHELLLAELLFNRFFNELSPEICACILSCFIFDEKIETQALKEELAKPFREIQAQARIIAKVSAESKLDVNEDEYVQSLKWQLMETVLAWAQGRPFSEICKMTNVYEGSLIRLFRRLEELLRQMAEAARVMGSEELKDKFELSLSKIRRDIVSFNSLYL
Protein: LD23155p (Rabaptin-5) (Q9W2M0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rabaptin-5-associated exchange factor for Rab5
- Ras-related protein Rab5
- TRAF3-interacting protein 1
- Golgi-localized, gamma-adaptin ear containing, ARF binding protein
- Receptor-mediated endocytosis protein 6 homolog
- small monomeric GTPase
- LD44762p
- LD29542p
- Intraflagellar transport 20
Sequence:
MEENETRSEAREPTDLPNGEDDATSQHKLSHLQNEMRKMQNEFNTQRAKMRELYIQKEAEVSQSQQERRQLQAELDELKTHLMVADLKSQNELQLRDLKAQEEISSLQQLVQDTIEETAHYKGEVERLRLELGKYQQIQQQTMAQQPQAESSGGIAPQVLNQVKKTLGSVRKLGTDSLNSSFQQDEDTRASSKGNGKQYAPEEAEMMHSIVEQLQEEMKALKVKLREQDEQLQAKSASDESALHKSTSMDVAESACESCSLAEKKTEELGAHINKQQKQVDLLQKQLVESRETLVKEAALRKDLEDQWQEKREAHKSEVQSLRDQAKTNEQRLLDMQQKFLETKDEVIKQIQRVSDDRERVNKQLETLQADNDFLSGRYLATSEEIDNQYINLPNTVVELQELILRQQSELIQARVSSEYERQKCTSTEDEIQILRAQLEESNNERRAYKRKMQLDIKSLQDRVTEHLVTVQAYETTKTQLERKEAELNKQLSECRVEIIELQEANEKYAKTNADYKTKIKTLQEELSTMETVQKDFVKLSQTLQMSLEELRHADTEVRWQDDDDVNNCPTCNAYFTVMVRKIHCRHCGHIYCDKCLTKTVPSGPRKRVARVCDICHTLLTPNTAPYFSQGQPPQQQQGQQQQQQSN
Protein: Pheromone-processing carboxypeptidase kex1 (EC 3.4.16.6) (Carboxypeptidase D) (Q2UPI1)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Peptidase A1 domain-containing protein
Sequence:
MFSSISRGFAKSETGDTFSFSFKSSWLLSLLVLWGPPLTTAKSAADYYVRSLPGAPDGPLLKMHAGHIEVDPQNNGNLFFWHYQNRHIANRQRTVIWLNGGPGCSSMDGALMEVGPYRLKDNLTLEYNEGSWDEFANLLFVDQPVGTGFSYVNTDSYLHELDEMSAHFIIFLDKFFELFPEYEGDDIYLAGESYAGQHIPYIAKAILDRNKNAVSPWNLRGLLIGNGWISPADQYPSYLTFAYEEGLIKEDSRTAKSLEVLQSVCQSKLETGGKDRIHIGDCETVLQELLSKTLDSDNKCYNMYDIRLRDTVPSCGMNWPQDLKDVKPYLRRADVVKALNINPEKKSGWEECSGAVSSSFLPQKSVPAVQLLPSLLESGISVLLFSGDKDLICNHVGTEQLINNMKWGGGVGFETSPGVWAPRHDWTFEGEPAGIYQHARNLTYVLLYNSSHMAPYDLPRQTRDMLDRFMKVDIASIGGSPADSRIDGEKLPQTSVGGHPNSTAAEEQEKERMKQAEWKAYAKSGEAVLVVVIIGVSVWGFFIWRSRQRHRRYQGLYHEDVSGASVLERFHNKRSGQDVEAGDFDESELDDLHSPDMAREHYTVGEDSDEDDVNRQHQRTTINPS
Protein: LD26135p (Q9W409)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein
- RE40275p
- LP07209p
- Transcription factor Ouib
- Serendipity locus protein beta
- Uncharacterized protein
- IP01295p
Sequence:
MICRLCLNALDEQSAVLLFDGAGGASAPAPDDEDDGKAMPESYLVQLISIHLYLCLSRDDAISTCICTECCSQLESFHNFWKLVELKQTTLCSQFLAIDCDVNWSEDGSETQLDAQPQLLLEPAEEPKVVTPTTANKFPCMFCEKSFKMRRYLEEHIATHTGDRPIACPYCEMAFRCRSNMYTHVKSKHTTQWLKAREERDAAKSNQNHTTPEETAPAVLVPVPAPAPALASAPASSASPGNTVNPAATATPASSATPTTNLAAAPLPSPPTVQQLPLSVIKSQPSEAMNLTITKTPPSGSRGSRNRSSRRKTHSPKKVQHTEGSDVSDEDSPQKRLKENELILANYNAVAAAVVAAASLTGNPPGQPDSLQQRLCASLLQQQHQEQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMAHPYGNHPPSETDKRPAAPLQAVIHAAPVSIICPNCGELPGQNHRCLSKPKYACDVCGKSFKMKRYLEEHFATHTGVKLHTCAFCPTEFRSKSNMYHHTKRKHKAEWERSRATRSAAKAGVQEQMQHTNPSQAQAQPGPAAAL
Protein: Potassium channel AKT2/3 (Q38898)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/protein kinase complex via a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21445098}; Multi-pass membrane protein {ECO:0000269|PubMed:21445098}. Note=Targeted to the cell membrane when interacting with CIPK6 and CBL4.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 6
- Calcineurin B-like protein 4
- Protein phosphatase 2C 37
- Protein MALE DISCOVERER 2
- Calcineurin B-like protein 1
- CBL-interacting serine/threonine-protein kinase 23
- Two-pore potassium channel 3
- Two-pore potassium channel 4
- Calcineurin B-like protein 9
- Calcineurin B-like protein 3
Sequence:
MDLKYSASHCNLSSDMKLRRFHQHRGKGREEEYDASSLSLNNLSKLILPPLGVASYNQNHIRSSGWIISPMDSRYRCWEFYMVLLVAYSAWVYPFEVAFLNSSPKRNLCIADNIVDLFFAVDIVLTFFVAYIDERTQLLVREPKQIAVRYLSTWFLMDVASTIPFDAIGYLITGTSTLNITCNLLGLLRFWRLRRVKHLFTRLEKDIRYSYFWIRCFRLLSVTLFLVHCAGCSYYLIADRYPHQGKTWTDAIPNFTETSLSIRYIAAIYWSITTMTTVGYGDLHASNTIEMVFITVYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVNRNRLPPRLKDQILAYMCLRFKAESLNQQHLIDQLPKSIYKSICQHLFLPSVEKVYLFKGVSREILLLLVSKMKAEYIPPREDVIMQNEAPDDVYIIVSGEVEIIDSEMERESVLGTLRCGDIFGEVGALCCRPQSYTFQTKSLSQLLRLKTSFLIETMQIKQQDNATMLKNFLQHHKKLSNLDIGDLKAQQNGENTDVVPPNIASNLIAVVTTGNAALLDELLKAKLSPDITDSKGKTPLHVAASRGYEDCVLVLLKHGCNIHIRDVNGNSALWEAIISKHYEIFRILYHFAAISDPHIAGDLLCEAAKQNNVEVMKALLKQGLNVDTEDHHGVTALQVAMAEDQMDMVNLLATNGADVVCVNTHNEFTPLEKLRVVEEEEEEERGRVSIYRGHPLERRERSCNEAGKLILLPPSLDDLKKIAGEKFGFDGSETMVTNEDGAEIDSIEVIRDNDKLYFVVNKII
Protein: Protein-lysine methyltransferase METTL21C (EC 2.1.1.-) (Methyltransferase-like protein 21C) (Q5VZV1)
Organism: Homo sapiens (Human)
Function: Protein-lysine methyltransferase.
Subcellular location: Nucleus {ECO:0000269|PubMed:23349634}. Cytoplasm {ECO:0000269|PubMed:32611769}.
Interaction partners:
- EEF1A lysine methyltransferase 2
- Elongin-C
Sequence:
MDVCLSSAQQPGRRGEGLSSPGGWLEAEKKGAPQKDSTGGVLEESNKIEPSLHSLQKFVPTDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGAMALCQYLEEHAEELNFQDAKILEIGAGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKNTLQCTAHLPEVKELVWGEDLDKNFPKSAFYYDYVLASDVVYHHYFLDKLLTTMVYLSQPGTVLLWANKFRFSTDYEFLDKFKQVFDTTLLAEYPESSVKLFKGILKWD
Protein: Regulator of G-protein signaling 4 (RGS4) (O08899)
Organism: Mus musculus (Mouse)
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Neurabin-2
- Regulator of G-protein signaling 7-binding protein
- Guanine nucleotide-binding protein subunit alpha-13
- Calmodulin-4
Sequence:
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDKVVTCQRVSQEEVKKWAESLENLIHHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLQPTITCFDEAQKKIFNLMERDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVSQCA
Protein: Serine/threonine-protein kinase 10-A (EC 2.7.11.1) (Polo-like kinase kinase 1) (XPlkk1) (B7ZR30)
Organism: Xenopus laevis (African clawed frog)
Function: May act as a polo kinase kinase by mediating phosphorylation of plk1/plx1 and subsequent activation of plk1/plx1 during oocyte maturation.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MAFANFRRILRLPNFEKKRLREYEHVRRDVDPNQVWEIIGELGDGAFGKVYKAKNRETGILAAAKVIETKNEEELEDYMVEIEILATCNHHFIVKLLGAFYWEGKLWIMIEFCPGGAVDAVMLELDRGLKEPEIKTICRQMLEALAYLHSMKIIHRDLKAGNVLLTLDGDIKLADFGVSAKNVKTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLSSLSKWSPEFHSFLKTALDKNPETRPSAAQLLEHPFVKKASGNKPLRDLVAEAKAEVLDEIEEQGEAEEEEDSDMLSPKTKGVSQSTHVEIGKDIEREQVGNGIKPHSATSPQKTDSQADNYSQRRNNEVKNCPENGRPDAVNGKPDIIILNPLSSNLEPKRNSTAESYRGEEHSSASSQRQRSAQSAELVPNGSFDSPTRYFTNWSKRDSDSGSNSASESMDISMNLSADLSMNKETGFLSHRENRLHKKTLKRTRRFVVDGVEVSITTSKIIGDDEKKDEEMRFLRRQELRELRLLQKEEHRHQAQLTSKHSFQLEQMSRRFEQEMNSKRKFYDTELETLERHQKQQIVWMEQEHAFRRRDEAKHIKTEQERDHIKFLEQLKLRKKELKAHVEKLPRQQRRETMKVQMDGFAHKKQTEEQQFVNRQKEDLNLAMRVIVLENRKEIYNKEREFLNKKQQLLRDRESVIWELEERHLQERHQLVKQQLKDQYFLQRHELLRKHEKEQEQMQRYNQRMMEQLRLRQQQEKVRLPKNQKAEAKTRMTMFKKSLHISPSGSAAEQRDKIKQFSLQEEKRQKAERLQQQQKHEHQLMEMLAECDCNVRDLLQMQNEKCHLLVEHETQKLKSLDEHHIQLIREWRENIRPRKKAFEDELELKKEAQEMFFRLNEEVAGDPFLSNKPTRFYSFSSPEAS
Protein: General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) (Q86UP8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor II-I repeat domain-containing protein 2B
- Neutrophil cytosol factor 1
Sequence:
MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYMERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFSRVEKSLKNFCIDWSKLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLASRNESDGLNYIPKIAELQTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT
Protein: Hapless 2 (Generative cell specific-1) (A0A060A682)
Organism: Tetrahymena thermophila
Function: During fertilization, required for the formation of intercellular membrane pores and subsequent exchange of gametic pronuclei between cells. Probably initiates the formation of intercellular membrane pores by inserting part of its extracellular domain into the cell membrane of the adjoining cell in the mating pair. Mating requires the presence of HAP2 on at least one of the two cells. Mating efficiency is high when HAP2 is present on both cells, and is strongly reduced when HAP2 is present on only one of the two cells.
Subcellular location: Cell membrane {ECO:0000305|PubMed:25155508, ECO:0000305|PubMed:28238660}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:25155508, ECO:0000269|PubMed:28238660}. Note=Detected at the mating junction. {ECO:0000269|PubMed:25155508, ECO:0000269|PubMed:28238660}.
Interaction partners:
Sequence:
MKFLAFGLIYFHFCILNRCEYITSSTIQKCYNSSNEPNNCSQKAVIVLSLENGQIANTEQVVATLNQLSDSGVNKQLQNSFIFEVTKSPVTALFPLIYLQDFNSQPLEQVIATTLFSCKDGFYDSSPTCKFQYDSKGQKILDSQGYCCYCSLSDILGMGNDLSRGKVCYALNLGAGSATAHCLKFSPLWYSAFKIQQYQLYFEVNINIYTVDSQNQKNLKQTLKLSTSNPTMKSSDNSTISKIIGTFTPTQPPADLSSYYLVKPSFPATDPRVLQGISSWMFVDKTMFTLDGTQCNKIGVSYSGFRQQSSSCSQPVGSCLQNQLENLYQSDLILLSQNKQPKYLLESQGNFNQVQFQGQTILQQGLSGSASTLITIEIDAAQIKFVTNLGIGCISQCSINNFESHSGNGKLVALVQNQGNYSAEFVLGFNCSSNVQPIQGQKLFLTANQLYNFNCSVSVNSDISAINNNCTINLYDAIGNQLDSKNILFNTTSTNHTSNQGNNTGQQQSSQEYKSSQSCSDKCSSFWSFWCYFSAGCIKEAFKSIASIAGVASALALVIFLAKNGYLVPIIRFLCCCCCKSKKKENEKNKDKTDKKSIQESCSYDRSCCSHSISQSYQVENKNKYKRSKIQRSFSSESCQDKSKKIINELSNLEETFEANKLYANIDKNSSIFEYFGFKKSFTFILYERNDILFLPQNSTILDMIGALQPQKGSYLAQKFLEIVNKNALKVVSTSPLYLLIE
Protein: Uncharacterized kinase mug58 (EC 2.7.-.-) (Meiotically up-regulated gene 58 protein) (Q9UUH3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Putative 2-hydroxyacid dehydrogenase UNK4.10
- Putative D-3-phosphoglycerate dehydrogenase
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Phosphoglycerate mutase
- Putative aldehyde dehydrogenase-like protein C922.07c
Sequence:
MSSLEIIVDKILKFLEKQPKPEGRPFILGISGPQGSGKSTLASALDTELTRKNESVVKFSLDDFYLTHAEQVELAKNNPNNPLVQHRGLAGTHDVTFLNNVLNAFVKGSDEEVSIPFYDKSKFGGYGDRGDESQWKKANPKTTTYVIFEGWMVGFEPLDSCMLSVRARSTRWQNIEGSLLWVNRKLADYQPIFQKIDSLVELEAQEINYVYRWRLQQEHALKARIHKGMSDEEVIEFVNHYMPQYVFYLGTLSNKVHLNPHCLEIILDENRYPVVMH
Protein: Adenosine receptor, isoform B (A0A0B4KHE7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSAFRYFSITDFSFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVDSPIWLRQQQEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPGSQRSSERNSSSTVPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDDDDLEFEDVFVPASSVPNPVQPGIDPVELRRSLALVMREKLRSDDTDSRPMGNNQDLPIDEQSRERPLSTQTSPTNGPLPALLRAKLLAGNSNSAHCLPGSTASPAPQEQSGIFVIDSEASPGSNGHKPKYRKGTAFTRSSLKKSRSCNCSSIAKGRGVHDEPSSNLCRDQESSVLPQHPQPANHPTENFFSPLRSVGSFMQHSNLFHFLQPHAARPTSSTASSTASTPTPSPPPMGQAQEESVPVGLTTSSPSLLATSAES
Protein: Isopentenyl-diphosphate Delta-isomerase I, chloroplastic (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase I) (IPP isomerase I) (Q38929)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Subcellular location: [Isoform 1]: Plastid, chloroplast {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
Interaction partners:
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Hydroxymethylglutaryl-CoA synthase
- Isopentenyl phosphate kinase
- Mevalonate kinase
- Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
- Farnesyl pyrophosphate synthase 2
- Farnesyl pyrophosphate synthase 1, mitochondrial
- Amyrin synthase LUP2
Sequence:
MSTASLFSFPSFHLRSLLPSLSSSSSSSSSRFAPPRLSPIRSPAPRTQLSVRAFSAVTMTDSNDAGMDAVQRRLMFEDECILVDENDRVVGHDTKYNCHLMEKIEAENLLHRAFSVFLFNSKYELLLQQRSKTKVTFPLVWTNTCCSHPLYRESELIEENVLGVRNAAQRKLFDELGIVAEDVPVDEFTPLGRMLYKAPSDGKWGEHEVDYLLFIVRDVKLQPNPDEVAEIKYVSREELKELVKKADAGDEAVKLSPWFRLVVDNFLMKWWDHVEKGTITEAADMKTIHKL