Protein: Tyrosine-protein kinase receptor cam-1 (EC 2.7.10.1) (G5EGK5)
Organism: Caenorhabditis elegans
Function: Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom-2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring by controlling axon guidance of SIA and SIB neurons. Involved in synapse plasticity by regulating delivery and/or stabilization of acetylcholine receptor acr-16 at post-synaptic membrane sites and the distribution of synaptic vesicles at pre-synaptic release sites. Probably by acting as a receptor for Wnt ligands cwn-1 and cwn-2, negatively regulates developmental neurite pruning of AIM neurons. Plays a role in ALM neuron polarity. By binding Wnt ligands mom-2, cwn-1 and egl-20 and thereby restricting their availability, negatively regulates Wnt signaling. This mechanism is involved in HSN neuron and QR neuronal descendent migration, and in vulva development. Involved in dauer formation, locomotion, tail morphology and egg-laying. May be involved in distal tip cell (DTC) migration during the development of the posterior gonad.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10476968, ECO:0000269|PubMed:15944127}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:10476968, ECO:0000269|PubMed:15944127, ECO:0000269|PubMed:19561603}. Cell projection, dendrite {ECO:0000269|PubMed:10476968, ECO:0000269|PubMed:15944127, ECO:0000269|PubMed:19561603}. Perikaryon {ECO:0000269|PubMed:15944127}. Synapse {ECO:0000269|PubMed:15944127}. Note=Localizes in punctate structures along neuronal processes where it partially colocalizes with synaptic vesicle marker snb-1 (PubMed:15944127). Localizes in punctate structures in the axons forming the nerve ring and in proximal AIM neurites destined for elimination (PubMed:19561603). Enriched at the distal tips of muscle arms where they interact with ventral nerve cord (PubMed:15944127). {ECO:0000269|PubMed:15944127, ECO:0000269|PubMed:19561603}.; SUBCELLULAR LOCATION: [Isoform b]: Cell membrane {ECO:0000269|PubMed:10556063}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:10556063}.
Interaction partners:
- Protein Wnt
- Frizzled-4
- Receptor-type tyrosine-protein phosphatase kappa
- Protein Wnt-2
- Protein Wnt-1
- DiSHevelled related
- Protein mom-2
- Vang-like protein
- Frizzled-2
- Abnormal cell lineage protein 44
Sequence:
MSPRPEDDDLVIEPADDEGLHYGNASMEGTSTGQRPYIRLTSQLRNATKSSGDEVRFKCEALGTPPLKFIWLKNNGPVEKTKRVKIRDKENSSRLVITQLDVLDSGYYQCIVSNPAASVNTTSVLRVNNVPDAVKLSQKKGSHHSTKHIAFDEYEDYEMMDRGRLPDEEDADLYRVPDSAAGSNYAPVAVSERWLDGIKYRVGDCVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQKCRQLSQAVACHHMYKVCESDSNNQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSRLSSTSNCIPVMSTALQSSPVAEVNRGHLTHWCYVNSGTQYEGTVAQTSSGKQCAPWIDSTSRDFNVHRFPELMNSKNYCRNPGGKKSRPWCYSKPMGQEEYCDVPQCPSDMYPHLNDKKVEGSTKGGVSESVTALWDSLDPTMQVALVGGGVFFSLLLLLLFCCACCCRAKKKSQKTRHQNAHCSSAPSVINSAANSAYYRKLNGTSTPIMGRVPPHVEMTSLLPSAQHLGPPPYPMDQHLQQARRFPSQEPIDDNSYKVFEITPSQLSVREKIGEGQFGVVHSGIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELLKVRVPPADHDMGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSWSLASPAHSILQQHNNRAGSHSGSSGAGRPPTHQRGYPSQKLHRRVEGASPLMKRHDANYAYSEDGDSD