wanglab/gogpt-training-data huggingface dataset:
Protein: Meiotic recombination 1 protein (P16523)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.
Interaction partners:
- Recombination protein 107
- Meiosis-specific APC/C activator protein AMA1
- Protein NAM8
- ATP-dependent DNA helicase MER3
- Sporulation-specific protein 22
- Meiosis-specific protein MEI4
- Pre-mRNA-splicing factor CWC26
- 56 kDa U1 small nuclear ribonucleoprotein component
- Meiotic recombination protein REC114
- U2 snRNP component IST3
Sequence:
MSNQHSPQPFCLDTKLVKLLEELQEGKQFNNKNIFPEKALYLKLALDYSFFRKNLLEFCVHLDKIKGVIRPNYDTIYILCLLEVDLLNLVFTDNILEICLPRFVSREDLRVFNNTFYTYHDNRLRILQEDFSQLFKKIKTKASVLCFTVEEIFLTNQEILPQNSTVAELQKSTNKVQTNGPQRHDFIVTLEIKLNKTQITFLIGAKGTRIESLREKSGASIKIIPISDKMTAHERNHPESVQQTILISGDLYSIALAVTSIESALITLDL
Protein: Disheveled-associated activator of morphogenesis 2 (Q80U19)
Organism: Mus musculus (Mouse)
Function: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (By similarity).
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Transforming protein RhoA
- Segment polarity protein dishevelled homolog DVL-2
- RIKEN cDNA 4930544G11 gene
- Disheveled-associated activator of morphogenesis 1
- Segment polarity protein dishevelled homolog DVL-3
- Profilin-4
Sequence:
MALRKRSPHGLGFLCCFGGSDLPEIDLRDSHPLQYLEFSGPIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAAMQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSGPPPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYITSRKVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALEESGEFDDLVSALRSGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINRLNY
Protein: tRNA-splicing endonuclease subunit SEN15 (Splicing endonuclease of 15 kDa) (tRNA-intron endonuclease SEN15) (Q04675)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular location: Nucleus {ECO:0000269|PubMed:12925762}. Endomembrane system {ECO:0000269|PubMed:12925762}; Peripheral membrane protein {ECO:0000269|PubMed:12925762}. Mitochondrion outer membrane {ECO:0000269|PubMed:12925762}; Peripheral membrane protein {ECO:0000269|PubMed:12925762}; Cytoplasmic side {ECO:0000269|PubMed:12925762}. Note=The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria, suggesting that tRNA splicing mainly takes place on the mitochondrial surface.
Interaction partners:
- tRNA-splicing endonuclease subunit SEN34
- tRNA-splicing endonuclease subunit SEN54
- tRNA-splicing endonuclease subunit SEN2
- Ribonucleases P/MRP protein subunit POP6
- RNases MRP/P 32.9 kDa subunit
- Ribonuclease P protein subunit RPR2
- Ribonucleases P/MRP protein subunit POP1
- tRNA ligase
- Ribonuclease MRP protein subunit RMP1
- Ribonucleases P/MRP protein subunit POP7
Sequence:
MATTDIISLVKNNLLYFQMWTEVEILQDDLSWKGNSLRLLRGRPPHKLSNDVDTEHENSLSSPRPLEFILPINMSQYKENFLTLECLSQTFTHLCSPSTERILLAIINDDGTIVYYFVYKGVRKPKRN
Protein: Sodium/potassium exporting P-type ATPase cta3 (EC 7.2.2.3) (Cation translocating ATPase 3) (P22189)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q01896}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Meiotically up-regulated gene 153 protein
Sequence:
MVTINISNPVYFSDIKDVESEFLTSIPNGLTHEEAQNRLSEYGENRLEADSGVSAWKVLLRQVLNAMCVVLILAAALSFGTTDWIEGGVISAIIVLNITVGFIQEYKAEKTMDSLRTLASPMAHVTRSSKTDAIDSHLLVPGDVVVLKTGDVVPADLRLVETVNFETDEALLTGESLPVIKDAHATFQMNEDVPIGDRINLAYSSSIVTKGRAKGICYATGMQTQIGAIAAGLRQKGKLFQRPEKDEPNYRRKLNKYYLKVTSYYVQRVLGLNVGTPLQRKLTVLAYILFCIAIILAIIVMAAHSFHVTNEVSIYAISLGISIIPESLIAVLSITMAMGQKNMSKRRVIVRKLEALEALGGVTDICSDKTGTITQGKMITRRVWIPSYGYLSVDTSDANNPTIGTVSGLEAAMQDVLKEKKQEMKNIDPSNQPSDQFIPLLKTCALCNLSTVNQTETGEWVVKGEPTEIALHVFSKRFNYGKEDLLKTNTFVREYPFDSEIKRMAVIYEDQQGQYTVYAKGAVERILERCSTSNGSTLEEPDRELIIAQMETLAAEGLRVLALATKVIDKADNWETLPRDVAESSLEFVSLVGIYDPPRTESKGAVELCHRAGIRVHMLTGDHPETAKAIAREVGIIPPFISDRDPNMSWMVMTGSQFDALSDEEVDSLKALCLVIARCAPQTKVKMIEALHRRKAFVAMTGDGVNDSPSLKQANVGIAMGQNGSDVAKDASDIVLTDDNFSSIVNAIEEGRRMFDNIMRFVLHLLVSNVGEVILLVVGLAFRDEVHLSVFPMSPVEILWCNMITSSFPSMGLGMELAQPDVMERLPHDNKVGIFQKSLIVDMMVYGFFLGVVSLMTWVVIMYGFGTGNLSYDCNAHYHAGCNDVFKARSAVFAVVTFCILIMAVEVKNFDNSLFNLHGIPWGEWNFRYFLHTLVENKFLAWAIALAAVSVFPTIYIPVINRDVFKHTYIGWEWGVVAVAVMFYFFYVEIWKSIRRSLTNPQKKGKFRRTLSNTITTESKLSEKDLEHRLFLQSRRA
Protein: Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109) (Q9BVC6)
Organism: Homo sapiens (Human)
Function: May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity).
Subcellular location: Nucleus outer membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}.
Interaction partners:
- Glutamyl-tRNA
- Trans-3-hydroxy-L-proline dehydratase
- Lengsin
- Glutamine synthetase
- GMP synthase
- Amidophosphoribosyltransferase
- Anaphase-promoting complex subunit 4
- Glutamine--fructose-6-phosphate aminotransferase 2
- Glutamine--fructose-6-phosphate aminotransferase 1
- Isoamyl acetate-hydrolyzing esterase 1 homolog
Sequence:
MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSVEEE
Protein: Olfactory receptor (Q8VGE3)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MAAENQSTVTEFILRGLTNRPELQLPLLLLFLGIYIITMVGNLGMITLIGLNSQLHTPMYFFLSNLSLVDLCYSSVITPKMLINFVSQRNLISYVGCMSQLYFFLVFVIAECYMLTVMAYDRYVAICQPLLYNIIMSPALCSLLVVFVYAMGLIGSTIETSLMLKLNYCEDLISHYFCDILPLMKLSCSSTYDIEMAVFFLAGFNIIVTSLTVLISYAFILSSILRISSNEGRSKAFSTCSSHFAAVGLFYGSTAFMYLKPSTASSLAQENVASVFYTTVIPMLNPLIYSLRNKEVKTALDKTLRRRVF
Protein: C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181) (P25024)
Organism: Homo sapiens (Human)
Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Interleukin-8
- Growth-regulated alpha protein
- C-X-C motif chemokine 5
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine 6
- Platelet basic protein
- C-X-C motif chemokine 2
- C-X-C motif chemokine 3
- C-C motif chemokine 2
- Fractalkine
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
Protein: Centrosomal protein 43 (FGFR1 oncogene partner) (A0A087WV25)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
Interaction partners:
Sequence:
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKTITQLECLLSIGALHFKNTADIF
Protein: Non-structural maintenance of chromosomes element 4 (Q54T56)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365071}.
Interaction partners:
- Structural maintenance of chromosomes protein 6
- Non-structural maintenance of chromosomes element 1 homolog
- Structural maintenance of chromosomes protein 5
- SP-RING-type domain-containing protein
- MAGE domain-containing protein
- Structural maintenance of chromosomes protein 3
- Structural maintenance of chromosomes protein
- Probable GH family 25 lysozyme 2
- Probable GH family 25 lysozyme 5
- Chalcone isomerase domain-containing protein
Sequence:
MNRNNSNGVGSSTGAGSSQSGIDNNNNNNNNSNNNNNRQQDESPNSKKVVKKQQQTIGERRELRKKYRTLIQDVSGNKSELILPSSDGLLRSLKKADNLYNNVLQAREAVLDSELLALASQFGVEQAQKFKVSLNGFDSFGLVNRYKERLTFYTDENNNNNSTINKTGWEKLSQLYHTHFHTVPDFDFMYGPINFEPEEKKVRAPRKLTQKDQPVGAAKHAEKITDTSNQVESETTSSRVQVMKQYIEKNPGKSFIDLVVDETSFAQTVENIFYFSFLLKDGHVKIAKDNEEMIIQTTLPPEEKDYQSKNAQLTHSVVKLDFNTWNDLKDISDLSFHMEEELQQFKNRRGGGGGGGSSTQTHTSTRK
Protein: Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) (Q8TAA3)
Organism: Homo sapiens (Human)
Function: Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CWH6}. Note=Localizes to the central region of the synaptonemal complex. {ECO:0000250|UniProtKB:Q9CWH6}.
Interaction partners:
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-7
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-9
- Proteasome subunit alpha type-2
Sequence:
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKKSV
Protein: Neurotrimin (Zgc:136455 protein) (B7ZV58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKNPVLWVVLIGISIALIQQGLPVRSQGESQSDNKQMDNITIRQGETLFLSCSQGDFVTHTAWLNRSSILYAGEDKWSVDPRVSLVTLSQEEFTIKIEDVDVTDEGQYICAVQTSSRPRTTSVHIIVQVPPKIVNLSRDLVVNEGSNVTLMCLANGKPEPAIVWRMKSPSDDSLSSDSEVLDIPFISRYRAGVYECTAANDIAVDTQTVELTVNYAPSVSDGRDVGVTLGQRGVLQCEADAVPEADFEWYRDDRRIFNGLDGIEIEAAGALSRLTFFNVSEADYGNYTCVAINKLGSANTSFVLYVQDGNSGTSTVFNPFCLLIAILQLLLKF
Protein: COP9 signalosome subunit 8 (E9PGT6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
Protein: tRNA threonylcarbamoyladenosine biosynthesis protein TsaB (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaB) (O05516)
Organism: Bacillus subtilis (strain 168)
Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17005971}.
Interaction partners:
- tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
- tRNA N6-adenosine threonylcarbamoyltransferase
- Putative [ribosomal protein bS18]-alanine N-acetyltransferase
- Threonylcarbamoyl-AMP synthase
- Bifunctional ligase/repressor BirA
- Thiamine-monophosphate kinase
- tRNA
- tRNA-specific 2-thiouridylase MnmA
Sequence:
MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVHSLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAANGRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLFLGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLAEAEAKWIESQK
Protein: Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) (O00628)
Organism: Homo sapiens (Human)
Function: Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11931631, ECO:0000269|PubMed:25538232}. Peroxisome matrix {ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:11931631, ECO:0000269|PubMed:25538232}. Note=Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5. {ECO:0000269|PubMed:25538232}.
Interaction partners:
- Peroxisomal targeting signal 1 receptor
- Peroxisomal membrane protein PEX14
- PEX5-related protein
- Peroxisomal membrane protein PEX13
- 3-ketoacyl-CoA thiolase, peroxisomal
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 10
- Peroxisomal ATPase PEX6
- Phytanoyl-CoA dioxygenase, peroxisomal
- Peroxisome biogenesis factor 2
Sequence:
MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPACLTIPA
Protein: Beta-defensin 2 (BD-2) (mBD-2) (Defensin, beta 2) (P82020)
Organism: Mus musculus (Mouse)
Function: Has bactericidal activity.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Beta-defensin 3
- Cyclin-T1
Sequence:
MRTLCSLLLICCLLFSYTTPAVGSLKSIGYEAELDHCHTNGGYCVRAICPPSARRPGSCFPEKNPCCKYMK
Protein: Membrane-spanning 4-domains subfamily A member 7 (CD20 antigen-like 4) (CD20/FC-epsilon-RI-beta family member 4) (Four-span transmembrane protein 2) (Q9GZW8)
Organism: Homo sapiens (Human)
Function: May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Scavenger receptor cysteine-rich type 1 protein M130
- B-lymphocyte antigen CD20
- Membrane-spanning 4-domains subfamily A member 6A
- Macrophage colony-stimulating factor 1 receptor
Sequence:
MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Protein: Ethylene-responsive transcription factor ESR2 (Protein DORNROESCHEN-LIKE) (Protein DRN-LIKE) (Protein ENHANCER OF SHOOT REGENERATION 2) (Protein SUPPRESSOR OF PHYTOCHROMEB 2) (Q9FYK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for correct embryo patterning and cotyledon organogenesis. May regulate positively the gibberellin signaling pathway leading to germination, hypocotyl elongation, and leaf expansion. Involved in the cytokinin signaling pathway that promotes shoot regeneration, probably through transcriptional activation of target genes such as CUC1. Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor BIM1
- At1g24600
- Floral homeotic protein APETALA 2
- Protein CUP-SHAPED COTYLEDON 1
- Protein WUSCHEL
- Protein SHI RELATED SEQUENCE 1
- Pseudo histidine-containing phosphotransfer protein 6
- Polyol transporter 5
- WUSCHEL-related homeobox 3
- Protein CUP-SHAPED COTYLEDON 2
Sequence:
MEEAIMRLEGAEHRETNIHSLKRKPSRTSSTAPGSPGGVTTAKAASGAGASGVSTIRYRGVRRRPWGRYAAEIRDPLSKERRWLGTFDTAEEAACAYDCAARAMRGLKARTNFVYPMPSLDSYHHRIFSSPPMNMFLLRDVLNSQSLSPLTTFAYPPCNLSNVNDVVHESFTNVNDVCEDLSPKAKRSSTIENESLISNIFEPEPASSGLLQEIVQGFLPKPISQHASIPPKSNQQSVGVFPTMPESGFQTDVRLADFHVEGNGFGQVKYHGELGWADHENGFDSAKMQQNGNGGMFYQYCFHDDY
Protein: Thiamine repressible genes regulatory protein thi1 (Transcription factor ntf1) (P36598)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcription factor that activates the nmt1 promoter. Regulation of thiamine repressible genes. Positively regulates conjugation during meiosis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
- Thiamine pyrophosphokinase
- Thiamine thiazole synthase
- Thiamine-repressible acid phosphatase pho4
- Manganese transporter pdt1
- Transcription initiation factor TFIID subunit 2
Sequence:
MNEEIGFLKNQLFADVKDLERKKKRRVPPEQRRRVFRACKHCRQKKIKCNGGQPCISCKTLNIECVYAQKSQNKTLSREYLEELSERQLCLEYIFSRMCPNFNLETKNLISISKKLSENENLPVSKIAEVTNELDTLVRINDQLSRNHISGTTEEMQSSSSLIAGEVQPGISFRDQLKVGKLEDTLYLGPTTSEAFIERLQNELELESISEDDLYSKRLSPSVSYSEFDEQLLLHARSLIPSKAVVEFLINSFFINVQTNLFVYHPHFFKCRLEIFLAMENQIDAGFLCILLMVLAFGNQYTAEQQEDVSKSNFHASNIGNRLFSAALSIFPLVLLQSDVSAVQSSLLIGLYLQSTIYEKSSFAYFGLAIKFAVALGLHKNSDDPSLTQNSKELRNRLLWSVFCIDRFVSMTTGRRPSIPLECISIPYPVILPDLEIPGSQSIVENMRAVINLAKLTNEICDSLYWNPSPSFESQVNSVRRIYARLELWKSDLHSSVVFDESAVQHPLFRSNAHVQMIYDNAIMLTTRVIMVKKLKDKDLTAENRRYIQLCVESATRVINIAHLLLTHKCLSSLSFFGLHVPFASAPILLLSLHYENSQDIQAVVTKLWQVLEFLSSRCEFARESLNYLKSFNKQLSRRNAPDINNPIADFQNSFQNWQSWVGDMSHGDMLSTFKLTGESSNGSNSTPNEAFQPFDQTSSLYNVPGLNKSYVSNQPSLLTPETFLPDPVLNLEVDKQWTAPTFLSWTELLGPTNVSEQSSHTAEQTSNLTLEKNG
Protein: Serine protease inhibitor 1 (Q2VMU2)
Organism: Onchocerca volvulus
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MNPFFIFITAFVVLFTYVDADQRKHKCKRPEIWEDCGGCELKCGQSDFAPCALRCNPPGCYCSPFYGLRRDSSGKCISKHQCPTRKHLNAPEDFILETDSVTYRNISEDSMKFRNITS
Protein: Microtubule-associated protein 9 (Aster-associated protein) (Q49MG5)
Organism: Homo sapiens (Human)
Function: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16049101}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16049101}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16049101}. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.
Interaction partners:
- Tubulin alpha-4A chain
Sequence:
MSDEVFSTTLAYTKSPKVTKRTTFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGDFSDTSADENSVNKKMNDFHISDDEEKNPSKLLFLKTNKSNGNITKDEPVCAIKNEEEMAPDGCEDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSSAENNSLDTDDHFKPSPRPRSMLKKKSHMEEKDGLEDKETALSEELELHSAPSSLPTPNGIQLEAEKKAFSENLDPEDSCLTSLASSSLKQILGDSFSPGSEGNASGKDPNEEITENHNSLKSDENKENSFSADHVTTAVEKSKESQVTADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKNKKSTNNRASSASARLMTSEFLKKSSSKRRTPSTTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWSPPSRTVFAKVF