wanglab/gogpt-training-data huggingface dataset:
Protein: Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) (Q62733)
Organism: Rattus norvegicus (Rat)
Function: Binds directly to lamin B1 and chromosomes in a mitotic phosphorylation-regulated manner. May play an important role in nuclear envelope reassembly at the end of mitosis and/or anchoring of the nuclear lamina and interphase chromosomes to the nuclear envelope.
Subcellular location: Nucleus inner membrane; Single-pass type II membrane protein. Chromosome {ECO:0000250}. Note=Tightly associated with the nuclear lamina.
Interaction partners:
- Lamin-B1
- Delta
- Lamin B2
Sequence:
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLAAGANSKGPPDFSSDEEREPTPVLGSGASVGRGRGAVGRKATKKTDKPRPEDKDDLDVTELSNEELLEQLVRYGVNPGPIVGTTRKLYEKKLLKLREQGAESRSSTPLPTVSSSAENTRQNGSNDSDRYSDNDEDSKIELKLEKREPLKGRAKTPVTLKQRRIEHNQSYSEAGVTETEWTSGSSKGGPLQALTRESTRGSRRTPRRRVEPSQHFRVDGAVISESTPIAETIKASSNDSLVANRLTGNFKHASSILPITEFSDITRRTPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSVPMWIKMLLFALVAGFLFLVYQAMETNQGNPFTNFLQDTKISN
Protein: Atypical kinase COQ8B, mitochondrial (M0R011)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRD
Protein: Fructose-bisphosphate aldolase (FBP aldolase) (EC 4.1.2.13) (Q6FLL5)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Phosphoglycerate mutase
- Phosphoglycerate kinase
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Glucose-6-phosphate isomerase
- Enolase 1
- Transketolase
- ATP-dependent 6-phosphofructokinase
- ATP-dependent 6-phosphofructokinase
Sequence:
MGVQEVLKRKTGVIVGDDVRALFDYAKEHKFAIPAINVTSSSTVVAALEAARDAKSPIILQTSNGGAAYFAGKGVSNDGQNASIRGSIAAAHYIRSIAPAYGIPVVLHSDHCAKKLLPWYDGMLEADEAYFKEHGEPLFSSHMLDLSEETDDENIATCVKYFKRMAAMNQWLEMEIGITGGEEDGVNNEHVDKESLYTKPETVFAVHEALAPISPNFSIAAAFGNVHGVYQAGNVVLSPEILADHQKYAAEKTGAPAGSKPLYLVFHGGSGSTQEEFNTGINNGVVKVNLDTDCQYAYLTGIRDYVLNKKDYIMSMVGNPEGADKPNKKFFDPRVWVREGEKTMSKRISEALDVFHTKNTL
Protein: Monoglyceride lipase (A0A3B3ITT3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLK
Protein: Elongation factor Tu (EF-Tu) (EC 3.6.5.3) (P-40) (P33166)
Organism: Bacillus subtilis (strain 168)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Elongation factor Ts
- Elongation factor G
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL4
Sequence:
MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGTAMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVEDVFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDNIGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFYFRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVSTITE
Protein: ERCC excision repair 1, endonuclease non-catalytic subunit (A0A8I6GI31)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
PGKASGRRVVRVRGGGGFQCPFPTPNSPFSSQAKPLFKSSRNPTPTAASTHSAPLTYAEYAIAQPPGGAGATVPTGSEPATGDSPSQTLKAGTKSSSIIVSPRQRGNPVLKFVRSVPWEFGEVTPDYVLGQSTCALFLSLRYHNLHPDYIHERLQSLGKNFALRVLLVQVDVKDPQQALKELAKICILADCTLVLAWSAEEAGRYLETYKAYEQKPADLLMEKLEQNFLSRATECLTTVKSVNKTDSQTLLTTFGSLEQLITASREDLALCPGLGPQKARRLFEVLHEPFLKVPR
Protein: WD_REPEATS_REGION domain-containing protein (Q9XUU8)
Organism: Caenorhabditis elegans
Interaction partners:
- Nucleolar protein 6
- HEAT repeat-containing protein 1 homolog
- WD_REPEATS_REGION domain-containing protein
- Bms1-type G domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- WD repeat-containing protein 46
- U3 small nucleolar RNA-associated protein 18 homolog
- rRNA biogenesis protein RRP5
- U3 small nucleolar RNA-associated protein 15 homolog
- U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein
Sequence:
MSICLEKQKIRCGMISRTARHIAIDENSGKMAIVRKSRSSETHDYIEFYNILSSWLAIPELTVCPENGSIEHLLFVDNGELMSSHANGSVCFIDPHNIERIKRIQISASTIWAACKHTENTIAMISHSSVLYFFDVSTKMIISSISLGVESRLFDVSSNGTIVAIGSIDGVIIAGDGKVQQTLKLDRLNRRDPTIAWSVLFVKPSLLACGDSRGTVTFWNPIDGSLIQSISCLQSHILAMVSTDNSTLNIAGVDPRITELRETRNGNYEIVNRRTGPARDVRSMAVYENIIFAAGEDFDVYTCKSGCQKLMFHQQKNLHVASDIVVSAGENYLDVMWKQSGEDEPSEGSVILQQHYEMIHLAKIFTPKKRIITCWAASPYGNLIAIGTCHDVTIYKISPMVKKINRKVVKTATLDVCATSLSITKNLRFYVAKSDFEVLEFDLETENGKELKSIISQADCGSVSRMVSSPCGNYICVLTTRSQIFSINTETGESRLLKVDLPIDMTINSTSAFVLSTITPNDSNNQQDTKKIFHEVNLSNGLIKRSACSNQLRMLPSSPKSLIPGQPIYLIGIDSNKIMTASYDGHWSILDVESGTVVSAQDGPLKANKKQRENEDTRLLVNGMRLREEVEQNGDGMSPSKRTRRNSFKNEIPPFQSMNSRIVQLEVTGDEIPKTAGFKIKKFGMQ
Protein: Ribosome-interacting GTPase 1 (GTP-binding protein RBG1) (Genetically interacts with ribosomal genes protein 1) (P39729)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ribosomal function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Translation machinery-associated protein 46
- Protein GIR2
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS19A
- Small ribosomal subunit protein eS6A
- Small ribosomal subunit protein eS12
- DNA polymerase epsilon subunit B
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS2A
Sequence:
MSTTVEKIKAIEDEMARTQKNKATSFHLGQLKAKLAKLRRELLTSASSGSGGGAGIGFDVARTGVASVGFVGFPSVGKSTLLSKLTGTESEAAEYEFTTLVTVPGVIRYKGAKIQMLDLPGIIDGAKDGRGRGKQVIAVARTCNLLFIILDVNKPLHHKQIIEKELEGVGIRLNKTPPDILIKKKEKGGISITNTVPLTHLGNDEIRAVMSEYRINSAEIAFRCDATVDDLIDVLEASSRRYMPAIYVLNKIDSLSIEELELLYRIPNAVPISSGQDWNLDELLQVMWDRLNLVRIYTKPKGQIPDFTDPVVLRSDRCSVKDFCNQIHKSLVDDFRNALVYGSSVKHQPQYVGLSHILEDEDVVTILKK
Protein: Embryo-specific protein ATS3 (Protein ARABIDOPSIS THALIANA SEED 3) (Q9LYP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role during embryo development.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Germin-like protein subfamily 1 member 5
- Germin-like protein subfamily 1 member 3
- UPF0540 protein At1g62060
- At2g03740
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 8
- Protein DETOXIFICATION 37
- Uncharacterized protein
- Gb|AAF18257.1 hydroxyproline-rich glycoprotein family)
- Late embryogenesis abundant domain-containing protein / LEA domain-containing protein
- Late embryogenesis abundant protein
Sequence:
MTFPSLSVSFLFFAFIFVTHAFDLSIIQMQQGTCPYTVVVMTSCLSPESTRDQISIVFGDADGNKVYAPKLGGLVRGPGGLGKCSTNTFQVRGQCLNDPICSLYINRNGPDGWVPESIEIYSEGSKSVKFDFSKSVPQLNTWYGHNNCNTTGRPSSPDLPPPHFPPEFPPETPTTPPPPPPRPSAASRLGNGESVFLAFAIATAIAAMVRWSY
Protein: Fructose-like permease IIC component 1 (PTS system fructose-like EIIC component 1) (P77579)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- PTS system fructose-like EIIB component 2
- PTS system fructose-like EIIA component
- PTS system fructose-like EIIB component 1
- Fructoselysine 6-kinase
- Multiphosphoryl transfer protein 1
- 1-phosphofructokinase
- Fructoselysine 6-phosphate deglycase
- PTS system fructose-like EIIB component 3
- Aminopeptidase YpdF
- Aminopeptidase YpdE
Sequence:
MAIKKRSATVVPGASGAAAAVKNPQASKTSFWGELPQHVMSGISRMVPTLIMGGVILAFSQLIAYSWLKIPAEIGIMDALNSGKFSGFDLSLLKFAWLSQSFGGVLFGFAIPMFAAFVANSIGGKLAFPAGFIGGLMSTQPTQLLNFDPSTMQWATSSPVPSTFIGALIISIVAGYLVKWMNQKIQLPDFLLAFKTTFLLPILSAIFVMLAMYYVITPFGGWINGGIRTVLTAAGEKGALMYAMGIAAATAIDLGGPINKAAGFVAFSFTTDHVLPVTARSIAIVIPPIGLGLATIIDRRLTGKRLFNAQLYPQGKTAMFLAFMGISEGAIPFALESPITAIPSYMVGAIVGSTAAVWLGAVQWFPESAIWAWPLVTNLGVYMAGIALGAVITALMVVFLRLMMFRKGKLLIDSL
Protein: Uncharacterized protein YffS (P76550)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Prophage integrase IntZ
Sequence:
MSYEIKICDILKGAAMEGQYKGAQRGAKCEEIANELTRRGVKNNKGEVITKGGVSHWLEGRREPNFDTLAELCDMFGVYALMPMRGGKWIRVHPEDRGEMELREAVAERDAIIDDLKARIAELEAALANKQVPAEAEEMGGEKVEEVAAEQAPNDEKEMGAKEWVNPNPKKYSVGMLCQVLAAMGGEYLGNNAGLQQKITVLDNDGNRKPISNGAFYRLIEQAKGRGLISVEQEIKHKKDENGNQIGKGKKGDKLITLLPNWIDKLGDE
Protein: UNC-34 (WH1 domain-containing protein) (G5EG53)
Organism: Caenorhabditis elegans
Interaction partners:
- Abnormal cell migration protein 10
- Protein sax-3
- Zyxin
- Netrin receptor unc-40
- Ras-related protein ced-10
- Netrin unc-6
- Actin-binding lim zn-finger protein limatin involved in axon guidance
- Rac-like GTPase
- Actin
- CRIB domain-containing protein
Sequence:
MSSEACIATAMARVMTYNESTKGWVLLGGNDDSMTNVRLIQDIRRPEFRIVSNRADSTNILNCNIYRGIKYHKATPMFHQWRTEQRRVYGLNFENEQDATMFLSIVLQAIETLKVHDMNGISDYQQMHQVDNVYQDPHQHLMHIHSAPNFHDENQNAANFRKTSQHASSLLSSTAAALTQQQRRASQSSSTSAGSSIPHAPPPPVPLTSNIPQAPPAPPPPIGGIAPVNAHGAPPPPPLPPVGAGAPPPPPPPPPPAQLMASSGTPSLAEQLKMRSQQGLKATSNGVKAAAAEPEKPAAKGAGNLMSELEAQLNKRKMTQAKSDAVDSKSNTSNGSSDSGCGTATSTNGCGSSNGGSVGSAAAKKWSVSDATKPMDSPKTHRKLPSASSLFSQEDSSSSSSSTLTPSKPTTNGTSSAIPNDLLERLRADIMVEMRLEMNKLEQRIVEANDRAVDRAVETILNAIGGRR
Protein: Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso) (A1KXC4)
Organism: Mus musculus (Mouse)
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:22988094, ECO:0000269|PubMed:25732732, ECO:0000269|PubMed:28135254}; Single-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28135254}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Note=Continuously recycles between cytoplasmic pool and the plasma membrane to bind as much IgM as possible (By similarity). In immature B cells, colocalizes with IgM in the trans-Golgi network and plasma membrane (PubMed:28135254). {ECO:0000250|UniProtKB:O60667, ECO:0000269|PubMed:28135254}.
Interaction partners:
- B-lymphocyte antigen CD19
- Fc receptor-like A
- B-cell antigen receptor complex-associated protein beta chain
- B-lymphocyte antigen CD20
- B-cell antigen receptor complex-associated protein alpha chain
- Low affinity immunoglobulin epsilon Fc receptor
Sequence:
MDFWLWLLYFLPVSGALRVLPEVQLNVEWGGSIIIECPLPQLHVRMYLCRQMAKPGICSTVVSNTFVKKEYERRVTLTPCLDKKLFLVEMTQLTENDDGIYACGVGMKTDKGKTQKITLNVHNEYPEPFWEDEWTSERPRWLHRFLQHQMPWLHGSEHPSSSGVIAKVTTPAPKTEAPPVHQPSSITSVTQHPRVYRAFSVSATKSPALLPATTASKTSTQQAIRPLEASYSHHTRLHEQRTRHHGPHYGREDRGLHIPIPEFHILIPTFLGFLLLVLLGLVVKRAIQRRRASSRRAGRLAMRRRGRGASRPFPTQRRDASQRPRSQNNVYSACPRRARGPDSLGPAEAPLLNAPASASPASPQVLEAPWPHTPSLKMSCEYVSLGYQPAVNLEDPDSDDYINIPDPSHLPSYAPGPRSSCP
Protein: Transmembrane protein (Q38DN2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWLFSRSNDTSAEAGIISSLPNAADAHTVTQKNMKTEGHEDHAVSTSLIDRSKINQLAVTKGDGRVSFFDTDSIDCIVKHYDKEMTVADQKIKQKQQKKERKMLNLYDYEGDRRYNQWLADQERVRENLKLHWLDFAIDRPMLCFKYLTRVGTTAGLFYGLGRSVFLYRTMDKMYAKLHGVSFSNIALYEVSLAVIKGTVVSAAGVVGVVVGESATNIATTVITGDISAPERTWVNVCVCGTSCGLFSGAAFAALHASTLTSWGMAAAATAMTVTGSIGGFGLGFYSYKPYAATREKRINDPYWRPWYQRRIADSGGAYMRGRYS
Protein: Lipopolysaccharide core biosynthesis protein WaaS (P27126)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Probable 3-deoxy-manno-octulosonic acid transferase
- Lipopolysaccharide 1,6-galactosyltransferase
- Lipopolysaccharide 1,2-glucosyltransferase
- Lipopolysaccharide core heptose
- Lipopolysaccharide glucosyltransferase WaaO
- Putative lipopolysaccharide heptosyltransferase 4
- Lipopolysaccharide core heptose
- Lipopolysaccharide heptosyltransferase 3
- Lipopolysaccharide glucosyltransferase WaaG
- O-antigen ligase
Sequence:
MTIYFINWVADYELKMIQYLKKKYKIKNITTPKKYNWINKKISKIGMDNAWLGRLFIKHYLNDIKKDDIIIINDSVVNKGINKQILKNINCHKVLLLRNTVGEDFILDNANYFDIIYDFEHRFIGNEKIKAIEQFFPIGMDEIRNYSLSDKNNSQPICFFLGRDKGRLQIINELAERLTTLGCKLDFNVVKDKTSSTTSKYLIEKQISYEENIRRTLNANIIVDITKENQSGWTLRILEALFFNKKLITNNINVFGSEIYSESRFFIIGHDDWDKLEYFINSSVKPMDYDSLYKFSPDKMMSTIVSDFIDK
Protein: Kunitz-type serine protease inhibitor BmKTT-3 (Delta-KTx 1.2) (P0DJ47)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Dual-function toxin that inhibits 85% of the activity of trypsin at a molar ratio of 4:1 with a dissociation constant of 760 nM, and that inhibits mKv1.3/KCNA3 potassium channel currents, but very weakly.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
KHGSINCRLPPERGPCRGNITKYYYHNESRTCRTFSYGGCEGNSNNFRNRHYCMKYCARKRHGWLGTGWI
Protein: RH63365p (Q8SWY7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFIVAVTGGIATGKSTISKVFERQGIPVIDADKIAREIVEPGQPCWRQIREVFGDEVLLPSKEINRAVLGKMIFEDKELRRKLNKITHPTIHRKIFWQVCKLLVTGHAWIVLDLPLLFETGVLMDFIHKIVCVTCDSDKQLERLIARNELSESEARHRVDSQMPLDKKCEKSHFVIDNNGSVEEAESSAMSIYNLMRDSKQHWLNRISFLGLFLIVGFTIYMLLKVFNRLPESWQM
Protein: ADRM1 26S proteasome ubiquitin receptor (A0A087WX59)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
Protein: Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1) (Q6UWB1)
Organism: Homo sapiens (Human)
Function: Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Interleukin-27 subunit alpha
- Interleukin-6 receptor subunit beta
- Interleukin-12 receptor subunit beta-2
- Ciliary neurotrophic factor receptor subunit alpha
- Interleukin-27 subunit beta
- Signal transducer and activator of transcription 1-alpha/beta
- Interleukin-12 receptor subunit beta-1
- Tyrosine-protein kinase JAK1
- Ciliary neurotrophic factor
- Tyrosine-protein kinase JAK2
Sequence:
MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA
Protein: Kinesin-like protein (Q7JMZ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSNKNTPVRQRIQQFQTRGVHKSTPASEMRKKVLITRAEDREHRDRPEQLLNTAFSGSTPQPKPKPTALNACYTPSSLYRNSNSTPGRAKTPGTGKSSCSRTKERDSLMESCLSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKASANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSYTTLVQQELQIMQRSAQRLRRHCEAALLERENHQDNGVLAVSLQEALARMDTVLNGMHTSLARAEATACVTSPTKTQKAVRFLID
Protein: E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (A0A1U9X8F2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
Protein: C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) (P04003)
Organism: Homo sapiens (Human)
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Subcellular location: Secreted.
Interaction partners:
- Complement C4-A
- Complement C4-B
- C4b-binding protein beta chain
- Basic salivary proline-rich protein 1
- Complement C3
- Complement factor I
- Vitamin K-dependent protein S
- Proline-rich nuclear receptor coactivator 1
- Statherin
- Salivary acidic proline-rich phosphoprotein 1/2
Sequence:
MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL
Protein: exodeoxyribonuclease III (EC 3.1.11.2) (G3V3M6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU362131}. Cytoplasm {ECO:0000256|RuleBase:RU362131}. Mitochondrion {ECO:0000256|RuleBase:RU362131}.
Interaction partners:
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYA
Protein: Copper-transporting ATPase PAA2, chloroplastic (EC 7.2.2.9) (Protein HEAVY METAL ATPASE 8) (B9DFX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates copper transfer across the chloroplast thylakoid membrane. Required for copper delivery into the thylakoids lumen, which is essential for the function of copper proteins.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:15772282}; Multi-pass membrane protein {ECO:0000269|PubMed:15772282}.
Interaction partners:
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Heavy metal transport/detoxification superfamily protein
- Plastocyanin major isoform, chloroplastic
- Heavy metal-associated isoprenylated plant protein 23
- Copper transport protein CCH
- Copper transport protein ATX1
Sequence:
MASNLLRFPLPPPSSLHIRPSKFLVNRCFPRLRRSRIRRHCSRPFFLVSNSVEISTQSFESTESSIESVKSITSDTPILLDVSGMMCGGCVARVKSVLMSDDRVASAVVNMLTETAAVKFKPEVEVTADTAESLAKRLTESGFEAKRRVSGMGVAENVKKWKEMVSKKEDLLVKSRNRVAFAWTLVALCCGSHTSHILHSLGIHIAHGGIWDLLHNSYVKGGLAVGALLGPGRELLFDGIKAFGKRSPNMNSLVGLGSMAAFSISLISLVNPELEWDASFFDEPVMLLGFVLLGRSLEERAKLQASTDMNELLSLISTQSRLVITSSDNNTPVDSVLSSDSICINVSVDDIRVGDSLLVLPGETFPVDGSVLAGRSVVDESMLTGESLPVFKEEGCSVSAGTINWDGPLRIKASSTGSNSTISKIVRMVEDAQGNAAPVQRLADAIAGPFVYTIMSLSAMTFAFWYYVGSHIFPDVLLNDIAGPDGDALALSLKLAVDVLVVSCPCALGLATPTAILIGTSLGAKRGYLIRGGDVLERLASIDCVALDKTGTLTEGRPVVSGVASLGYEEQEVLKMAAAVEKTATHPIAKAIVNEAESLNLKTPETRGQLTEPGFGTLAEIDGRFVAVGSLEWVSDRFLKKNDSSDMVKLESLLDHKLSNTSSTSRYSKTVVYVGREGEGIIGAIAISDCLRQDAEFTVARLQEKGIKTVLLSGDREGAVATVAKNVGIKSESTNYSLSPEKKFEFISNLQSSGHRVAMVGDGINDAPSLAQADVGIALKIEAQENAASNAASVILVRNKLSHVVDALSLAQATMSKVYQNLAWAIAYNVISIPIAAGVLLPQYDFAMTPSLSGGLMALSSIFVVSNSLLLQLHKSETSKNSL
Protein: Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) (O89079)
Organism: Mus musculus (Mouse)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit delta
- Coatomer subunit beta'
- Coatomer subunit beta
- Coatomer subunit alpha
- Coatomer subunit gamma-1
- Coatomer subunit zeta-1
- Protein SEC13 homolog
- Coatomer subunit gamma-2
- Coatomer subunit zeta-2
- ADP-ribosylation factor 1
Sequence:
MAPPVPGAVSGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENQRDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECMAMTIQILLKLDRLDLARKELKKMQDQDEDATLTQLATAWVNLAVGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLSQLKDAHRAHPFIKEYQAKENDFDRLAMQYAPSA