wanglab/gogpt-training-data huggingface dataset:
Protein: Signal transducer and activator of transcription (K7EK35)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
Protein: Vacuolar protein sorting-associated protein 60.1 (Q9LPN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular location: Endosome, multivesicular body membrane {ECO:0000269|PubMed:20663085}; Peripheral membrane protein {ECO:0000305}. Note=Localized in multivesicular body when associated with SKD1. {ECO:0000269|PubMed:20663085}.
Interaction partners:
- Protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5
- Protein SUPPRESSOR OF K
- Vacuolar protein sorting-associated protein 2 homolog 2
- ESCRT-related protein CHMP1A
- Vacuolar protein sorting-associated protein 32 homolog 2
- Vacuolar protein sorting-associated protein
- Vacuolar protein sorting-associated protein 32 homolog 1
- Vacuolar protein sorting-associated protein 2 homolog 1
- Vacuolar protein sorting-associated protein 2 homolog 3
- ESCRT-related protein CHMP1B
Sequence:
MRRVFGAKKNTEPPPSIQDASDRINKRGDSVEDKIKKLDVELCKYKEQLKKTRPGPAQEAVKARAMRVLKQKKMYEGQRDMLYNQTFNLDQVSFAAEGLKDAQQTMTALKSANKELKGMMKTVKIQDIDNLQDEMMDLMDVSSEIQESLGRSYNIPDGLDEDDLMGELDALEADMGNETEADGMPSYLQPDTETDYDSELNLPAAPTGHNGAPHGRAQAEDEFGLPAVPRASLRG
Protein: Protein aurora borealis (H2FLK2)
Organism: Caenorhabditis elegans
Interaction partners:
- Fe2OG dioxygenase domain-containing protein
- Methyltransferase BUD23
- Serine/threonine-protein kinase plk-2
- Serine/threonine-protein kinase plk-1
- Methyltransferase N6AMT1
- rRNA N
- Ubiquitin-like domain-containing protein
- tRNA
- tRNA
- Cyclin-dependent kinase 1
Sequence:
MEFNVSSFCEGEESRQLNSTALEHDENGRTAEWKVSPIAAERPSKIFPNKARSGFKTPLRSINTTDPSTSGYDSKSITPQQNDPKLSMSAELSSFIANNSLNPLDSILLNSLHKSINFSPRVVFSQESCSQQKDSEKFQWSIEQLAILKPAHISDDEIAASYRSPIPEVEEKIQEVLNEYWTKNVSYIPSPDGPRYINLSHRDGTVTTFTYGAEENATSSSAPGAAAGTPASLANIVRKKEAVKAAYATSSPKQRPRNFRNIRQVRNRPAQTELTIPPNLDLDLKKLLGEQFVYQPDEEDEEDDEEVFNVSVSSNFSTRRRLFSAGGTPGAPRDDEDEADDVENSSMLSNDDLMLNETNGQHFNDSLSPVRKDVTDDIDEPETSMTTSGATASQIAINISILNDCMMNSIDEEEIDGNEEEGKNEAVHHQHNVFSHSHLDANEYEILDRSSSSNATPRHEDLDWTPRRFPGSANSNPMLRGIITSGGSGGGGPQDFRRFVFDMSPIHPNHNAPGAMRTPLQRCHPVNLPRGRLDLNDDDEEDENTEK
Protein: Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.354) (COMPASS component set1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1) (Set1 complex component set1) (Set1C component set1) (Spset1) (Q9Y7R4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.
Subcellular location: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Interaction partners:
- Set1 complex component swd1
- Set1 complex component sdc1
- Set1 complex component swd3
- Set1 complex component ash2
- Set1 complex component spp1
- Set1 complex component swd2
- Histone H3.1/H3.2
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- SET domain and MYND-type zinc finger protein 6
- Set1 complex component shg1
Sequence:
MDFNTSTRSKSQPVQRNNYKVLYDPELGIKENLGRKIIYRFNGVSKPPLVVRDPRLKNPIYARGIPKSGRPFLKSLQTINYDYNENSLGPEPPTQVFVSNISPLVTSEQLRYHFKSFGEVFDLDLKLNPYTGTSLGLCCISFDKRSSISVAAHSAKIAVQQANGLRFSGKPLSVVLDRDGSLCEEAFKKALNAVEKQFQEETLQKQRFEREDESSRQKLSAAMNEDIPPWRQPSKNSQTLSNGDLQHSKVQNVDQKSGFLTSSETDVPKNINDYIYLLIDDRFVPPDRVYYTDIKHHFRKFLYEKIYMNKDGFYITFNNYREASNCYRALDRTYVQNCRIKLKFHDIPSRTKEDGKKSAVRRVVLPPEEAYAEATSVVLRDLEAALLRDVKSKIIGPAIFKYLHSMPKPSVKEELQENLLVSSTSVPDVPLKIESTVGKLPSLPKFKKRVDSSKMNLSAGSKTKSKLQRRRRRRHEARPLHYQLNQMYNSSASEAESDQELLLSSGDERVERGKIGSIKSVKSDEATPVFSDTSDENDKFHRFRTKSKISKKKYEKMEVDYTSSSETESDASILSPSAAIPKSGSAIKDELISPKKEIDEVLALAPKWRINEFDETGSVYYGALPYNYPEDDVLLDLDGLQYLVKNDEDYSYLQEALKDEPLMDINDPNFWAYERKSCKFKNGDVKYGDTAILPEPKGYFRSNTSGSAKSEGYYIIPTTEKSLYLPLRNRSTIDTISHSTSRITSRMNRVNNRRLAAGVEKSQLPAEADLLRFNALKARKKQLHFGPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNREKNYVREGIGDSYLFRIDEDVIVDATKKGNIARFINHSCAPNCIARIIRVEGKRKIVIYADRDIMHGEELTYDYKFPEEADKIPCLCGAPTCRGYLN
Protein: Battenin (Q9VVL0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Interaction partners:
- Palmitoyl-protein thioesterase 1
- hydroxymethylglutaryl-CoA lyase
- Cln7, isoform A
- Cathepsin D
Sequence:
MTATKQQEAEAEHDPQVVVTPGDASRSSRQDRGLWRDLTSYWILGLCNNYGYVVMLSAAHDIIKQFNPNDESEESSSGRNCHLVSTGAILLADVLPSLFVKILMPFFPFWVNFRIALAVAFSAAGFLLVGFANAEWMALLGVIITSASSGIGETTFLAYSSRYNKNVISTWSSGTGGAGVIGSLSYASLRSLDFSPRDTMLIMLIFPAIEAFAFWLLLRRPQVDILPVTTVESTEVLISDEKPLVGFKEKLFYIKHLFKYMLPLCLVYFFEYFINQGLFELVYFEDIFLDKDSQYRWLNVDYQIGVFISRSSVNLFQLDKIWLMSIFQFVNVVYFLTEVIWWYTPSIWIVFAIVLWEGLLGGGAYVNTFYRMSKEISPERQQFAMAMVVQSDSYGIALAGFLAIPVHNAICGLPAAARSLVW
Protein: Putative axial regulator YABBY 2 (Q9XFB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the abaxial cell fate determination during embryogenesis and organogenesis.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription repressor KAN1
- Probable transcription factor KAN2
- Protein ASYMMETRIC LEAVES 2
- Probable transcription factor KAN4
- Probable transcription factor KAN3
- Auxin response factor 3
- Transcription factor AS1
- Auxin response factor 4
Sequence:
MSVDFSSERVCYVHCSFCTTILAVSVPYASLFTLVTVRCGHCTNLLSLNIGVSLHQTSAPPIHQDLQPHRQHTTSLVTRKDCASSSRSTNNLSENIDREAPRMPPIRPPEKRQRVPSAYNRFIKEEIQRIKACNPEISHREAFSTAAKNWAHFPHIHFGLKLDGNKKGKQLDQSVAGQKSNGYY
Protein: Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) (Q9HBR0)
Organism: Homo sapiens (Human)
Function: Putative sodium-dependent amino acid/proton antiporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVGGTFRMFLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQAPGPPEES
Protein: FYN proto-oncogene, Src family tyrosine kinase (E5RIX5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYS
Protein: Low affinity potassium transport system protein (Q8L8X4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLLAVEGGGLFSASASGYSKGLTLLFSGDKDVDRPMRVVPWNHYQVVDQEPEADPVLQLDSIKNRVSRGCAASFSCFGGASAGLETPSPLKVEPVQQQHREISSPESVVVVSEKGKDQISEADNGSSKEAFKLSLRSSLKRPSVAESRSLEDIKEYETLSVDGSDLTGDMARRKVQWPDACGSELTQVREFEPSEMGLSDEEWEVGRQRTCSCVIM
Protein: Guanylyl cyclase domain-containing protein 1 (RCG61032, isoform CRA_d) (R4UB37)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRTEVEAAGQPLEPEDFVQLPVPTIQQLYHWDCGLACSRMVLRYLGQLDDGEFENALQELQLTRSIWTIDLAYLMRHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVQVEKCTVSVQDIQAHLAQGHVAIVLVNSGVLHCELCSSPVKYCCFTPRGHRCFCRAPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISNFEEARTSYGTDEDILFVYLDS
Protein: Vacuolar protein sorting-associated protein IST1 (Increased sodium tolerance protein 1) (P53843)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole. Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex.
Subcellular location: Cytoplasm. Endosome. Note=The endosomal location appears to be dependent on DID2.
Interaction partners:
- Vacuolar protein-sorting-associated protein 46
- Vacuolar protein sorting-associated protein VTA1
- Vacuolar protein-sorting-associated protein 60
- Vacuolar protein sorting-associated protein 4
- Vacuolar protein sorting-associated protein 20
- Vacuolar protein-sorting-associated protein 24
- DOA4-independent degradation protein 4
- Vacuolar-sorting protein SNF7
- Uncharacterized protein YJL049W
- Vacuolar-sorting protein BRO1
Sequence:
MAPSMIPFTIKLKTCLKMCIQRLRYAQEKQQAIAKQSRRQVAQLLLTNKEQKAHYRVETLIHDDIHIELLEILELYCELLLARVQVINDISTEEQLVKEHMDDGINEAIRSLIYAILFVDEVKELSQLKDLMAWKINVEFVNGVIADHIDVPEKIIKKCSPSVPKEELVDLYLKEIAKTYDVPYSKLENSLSSSSSNISSDFSDPSGDIEDNDEEKPILALDNDDNDNADAKHPITVKKPRQNSENIKNELKIPKDIKKEVIEKKQSEKKTTKRKTKKEQENDELDELKKRFDALRRK
Protein: Prolactin receptor (PRL-R) (Q90374)
Organism: Columba livia (Rock dove)
Function: This is a receptor for the anterior pituitary hormone prolactin.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MKQKLRSSVQIILLFALTAVGLTGQSYPGKPKIIRCRSLEKETFSCWWKPGSDGGLPTNYTLFYSKDSEEKIYECPDYGMSGPNSCYFDKNHTNPWTTYNITVMAMNEIGSNSSDPQYVDVTSIVQPDAPVNLSLETKTSASTTYLLAKWSPPPLADVTSNSHVYRYELRLKPEEKEEWETVSVGVQTQYKVNRLQAGVKYVVQVRCVLDIGEWSEWSSERHIHIPNGESPPEKPTIIKCRSPEKETFTCWWKPGSDGGHPTNYTLLYSKEGEERVYECPDYKTAGPNSCYFDKKHTSFWTIYNITVKATNEIGSNVSDPLYVDVTYIVQTDPPVNVTLELKKTVNRKPYLVLTWSPPPLADVRSGWLTLDYELRLKPEEAEEWETIFVGQQTHYKMFSLNPGKKYIVQIHCKPDHHGSWSEWSLEKYLQIPTDFRIKDMVVWIIVGVLSSLICLVMSWTMVLKGYRMIAFILPPVPGPKIKGIDTHLLETGKSEELLSALGCHGFPPTSDCEELLIEYLEVEDSEDQQLMPSHDNGHPSKNAKMIAKETDSDSGRGSCDSPSLLSEKCRESRAILSTLQTQDIRDVQENNGRRHWETQCIASEQKILLFNNESTKSPIWPAAQLPDNQPPMFAYHSTVDVHKITLCTIDVNIAPVLVENEEQHQPQYPITETVHDNMEKHREVENLYSKTDQTTVQVKQNRPNDKSPFSKPKLMDYVEVHKVRQDEVAAVLLKHKENSGKIEKYTVPGTSKEYTKVSTVVDHNILVLMPDSRIQHIPVSQEPAMEMSQNLQQGQTEKNMSYCLTVPSECKRETSASEYMDPSSFIPAFK
Protein: C2H2-type domain-containing protein (Q9D5K8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKKVKDSPMGKVDFPHQRCGQGEAEHDSHQMCVKAAFPNDVSRVITTGGSYCSIIEEPWQGGDPKTSDPQNHIPPSSSGAFFSQKTLITDGREAAGGSIPLGAHVISTQKRSLRCCPCEKTLQPHLQADRDHQSSATEQPDGIVDSCQSFTQGLPTAVCPIHSTGEEARRGDQCASVPSPQQPFMQHGTLSQDKPVEYTKYEKVFTAGSALCQQQTTNPLEKHFICHICGKSFLQKSELSFHPGTDRGETHHGCPGCRKSLPSTSSLQARHGTHTKEKPYRCPDCGKSFSYASHLKIHLRIHTGERPYVCSDCGKAFSQKSVLTTHRRIHTGERPYTCNHCGKLFVYASDLKKHSRFHTGEKPYECRDCGKLFNNKSHLPVHYRIHTGEKPYRCCDCGKSFRRKSHLKVHSRTHTGEKPYECPDCGRAFSHSSVLSTHQRIHTGERPYLCSDCGKAMSSKAQLNEHRRIHTGEKPYVCSECGKAFSCRSSLQAHRRTHSREKPFVCHTCGKGFLHKSQLSSHQQTHTGENP
Protein: Type I iodothyronine deiodinase (EC 1.21.99.3) (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) (Q61153)
Organism: Mus musculus (Mouse)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P24389}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P24389}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P24389}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P24389}. Basolateral cell membrane {ECO:0000250|UniProtKB:P24389}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P24389}.
Interaction partners:
- Type II iodothyronine deiodinase
Sequence:
MGLPQLWLWLKRLVIFLQVALEVAVGKVLMTLFPGRVKQSILAMGQKTGMARNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSGQKCNIWDFIQGSRPLVLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNNVDIRQHRSLQERVRAARLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKAGPWNYNPEEVRAVLEKLCTPPRHVPQL
Protein: Transglutaminase-like domain-containing protein (Q55FC8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- UV excision repair protein RAD23 homolog
Sequence:
MNQSKTINLIYNDKEYLVEVENECTYEDFQILVFSVTDVDPTFQRFYYLSNSKLRDPSPTEKIIVLNNQKILLSNLKSFKLPIKIENGLKNKIEGMYRNMISYNSDRLQQMALDQVPLEIKKEKDLKRKMLMLLDWFKNEYFTWTNSPECSDIKCGTPSTSSVGSDRPTFEEQSHQVSIVEVYRCASNHVTRFPRYNSVEKLLSTKCGRCGEWANAFTLFSIALGFTTRYILDFTDHVWNEVYIDGRWIHVDSCEATYDSPLTYEGGWGKQLSYVFAFEFNGIYDVTSRYSIKLPHLNRYLISESDLTNYLNHLNHQIRSTLPFDELRSILNREFLEDNEKQSYHQRTYSSDLTGRISGSSEWRNNRGESGNNNQQQQQQQQQQSEIPIILKPIYSLDSISKARESLKLVGNCDITKNGICLTPDENDRVGGFWIKERIDIISNGGFICKFKFLIKTNGADGMAFVIQNDSINSLGIGGCGLGYQGIRNSIAIEFDTYPTKDHCKDPDGNHISIHTRSLEPNSSHHRFSLGYGNPKNNKPMNDGIEHECFIKYSTSNGDDGDSTIDVWLDKYQVLYKIKANIQKLLNLHENKSCFIGMTASTGGLKQAHIISGFSIGY
Protein: Cell division control protein 10 (P39827)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis.
Subcellular location: Bud neck {ECO:0000250}. Note=Present at the bud neck during cell division. {ECO:0000250}.
Interaction partners:
- Septin
- Septin CDC11
- Septin
- Septation protein 7
- Septin
- Bni4p
- Bud site selection protein BUD4
- Spr28p
- Serine/threonine-protein kinase GIN4
Sequence:
MSIEEPSTQHIAQPQKYVGFDTITTQIENRLLKRGFQFNIMVVGRSGLGKSTLVNTLFSSKLTTSQGRKSPSEPIEKTTEIKVASHSLLENNVRLNINVIDTPGFGDQINNEKCWEPLVKYVKEQHSQYLRKELTAQRDKFLADTRVHCILYFIPPNGQKLKQLDVQALKKLSEIANVVPIIAKSDSLTLDERSEFKKLLQSEFMKYNFNIYPYDSEDLYEEERQLNEDIKSLIPFAIAGSETEIEINGEMVRGRKTKWGAINIEDVSQCEFVFLRDFLTRTHLQDLIETTALTHYETFRSKQLIALKENASNPNRQSQLQKDQGQTSQQSNQDLKNTSGVPNAPMFQSTTGTAAAR
Protein: Drebrin (Developmentally-regulated brain protein) (Q16643)
Organism: Homo sapiens (Human)
Function: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20215400, ECO:0000269|PubMed:28966017, ECO:0000269|PubMed:8838578}. Cell projection, dendrite {ECO:0000269|PubMed:8838578}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20215400}. Cell junction {ECO:0000269|PubMed:20215400}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXS6}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.
Interaction partners:
- Microtubule-associated protein RP/EB family member 3
- MYND-type zinc finger-containing chromatin reader ZMYND8
- Gap junction alpha-1 protein
- Adenylyl cyclase-associated protein 2
- C-X-C chemokine receptor type 4
- F-actin-capping protein subunit beta
- Mitogen-activated protein kinase kinase kinase kinase 3
- Gelsolin
- Homer protein homolog 2
- Adenylyl cyclase-associated protein 1
Sequence:
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
Protein: Chloride channel protein 2 (ClC-2) (Q9R0A1)
Organism: Mus musculus (Mouse)
Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P35525, ECO:0000269|PubMed:22405205}; Multi-pass membrane protein. Myelin membrane {ECO:0000269|PubMed:17567819, ECO:0000269|PubMed:22405205}. Basolateral cell membrane {ECO:0000269|PubMed:16155254, ECO:0000269|PubMed:18801913, ECO:0000269|PubMed:22079595}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:P35525}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P35525}. Note=Sorting to the basolateral membrane is mediated by AP-1 clathrin adapter (PubMed:16155254). Localizes at axon initial segments and dendritic shaft and spikes. Colocalizes with HEPACAM and GFAP at astrocyte end-foot in contact with brain capillaries and other glial cells (By similarity) (PubMed:17567819, PubMed:22405205). {ECO:0000250|UniProtKB:P35525, ECO:0000269|PubMed:16155254, ECO:0000269|PubMed:17567819, ECO:0000269|PubMed:22405205}.
Interaction partners:
- Voltage-dependent T-type calcium channel subunit alpha-1H
Sequence:
MAAATAAAAAAAAAGEGMEPRALQYEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGSPSARATPELLEYGQSRCARCRICSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQAQQWMSRGLNTNILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYEHESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEDLELPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQKLRKAQLSPPSDQESPPSSETSIRFQVNTEDSGFSGAHGQTHKPLKPALKRGPSNSTSLQEGTTGNMESAGIALRSLFCGSPPLEATSELEKSESCDKRKLKRVRISLASDSDPEAEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPRSRHGLPREGTPSDSDDKCQ
Protein: Mucin 16 (A0A140LI05)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XYHHQYWTPKTSTTNPSLVPFTLNFTITNLHHTEGMASQGSEIFNSTERILNSLLKPMFKNSSIGHLYSGCRLITLRPEKDGTATGVDAVCTLHSDPLGLQLDREKMYWELSHNTQGVTKLGSFTLEKDSLYINVPGSPLVPFIINFTITNLEYEEGMSHAGSWKFNATEKILQRLLWSLFNKTSIGLLYSDCRLALLRPEKDGAATGVDAICTHHAGPIGPGLDSERVFWELCNLTNNVTKLGPYTLDKNSLYINGYTHQIQSITSPTTSPSLLPFTLNFTITNLQHTEGMAFQGSEIFNNTERILNSLLKPIFKNSSIGHLYYGCRLISLRPEKDGTATGVDAVCTLHSDPLGLQLDREKMYWELSHNTQGVTKLGSFTLEKDSLYINVPLSSLVPFTINFTITNLKYEEGMNHPGSWKFNATERILQRLLWPLFNKTSISLRYSNCRLALLSERVFWELCNLTNNVTQLGPYTLDKNSLYINGEQWPCYTHQIQSITSPTAGPVLEHFTINFTIINLKFEEDMSHPGSRKFNITERTLQRLLRILFKKSSVGALYSGCKLSLLRPENDGAGTGVDAVCTHYPDPTGLGLDRKMLYGEISRLTYGVKRLGPYTLNDKSLYVNGYTHQIVATTTQMAMMTIASMGMINNSPSPTAGSGLVPFTINFTVTNLKYVENMHHPGSRKFNTTERILQKLLKALFSKTSVGPLYSGCRLILLRLEHNGTATGVDAICTYHPNISNQGLDRERVYWELKRLNITQLGPYIVDENSLYINGYTQQILSTTSRPSVMATVSEGMPNISSTPTATSPVLVPFTINFTITNLEFKKDMGRPGSRKFNVTERTLQSLLRPLFIKTSVGQLYSGCRITLLRPEKNRAATGVDATCTYHLDPAGHRLESEQIYEELSNLTQSVTQLGPYILDQNSLYVNGYTDQILATTPRALSSALLRCTLNFTITNLPHTNDMWVPGSAKFNKVEKILKLLLKPLFQNTSVGLLYSGCRLTSLRPKKDGEATRVDMVCTYHPNTTGTGLDREQLYLELEQLTHNITQLGPYSLDQNSLYVNGYTHQTAVTSPSKSPLEIFTFNFTITNLLYTENMQPPGSKKFNTIEKILQGLLGSLFKNTSIGPLYTGCRLTSLSSRKDGKATEVDTVCSYYADHMGPGLATEQLYLELSNLTHGVTKLGPYTLDQDSLYVNDYTYSASSIFHNTSSLVPYSTNNSTGNGTVMVSITLNFTITNLHYTEEMGHPGSLKFNSTKWTLHYWLDTLLNKTSIAPLYSGCRLASLRSDDHRAATEVDVICNFHSYSMSPGVNQDQLFWELSHGTHGITHLGPYTLDQNSLYINGNSFGAAAPNTTTGELSEELFTVNFTINNLRYSADMSQIGSPKFNITDTLMQHLLGPLFQRSSLGPLYTGCRVATLRSMKNGAQTQVDVLCTYRRVFNSQGLPAKPIFYDLSWQTHGITKLGPYSLDKDSLFINGYNEPGPDVPPTTPEPATTILPSPTTSLQPESNTVMWHKPETFTINFTISNLPYSVDMISGSAIFNSTENVLQRLLGPLFQNDSFNSSCRLTSLRPEKNGMFTGVVTTCTYQNDPAHPGMDIQGLYSELSHLSHGVTQLGNYTLEEHSLYVNGYPILGPDILTTTPEPSTTILPFTLTSVQPESTTARAHHLKTITINFTISNLPYSAEMNYSSAMFNSTESVLQHLLRPLFQNNSFNASCRLTSLRPEKNQNSTNVNVICSYQHYSAHPGLHTQELYSELSHLTHGFTQLGNYTLDKDSLYVNGYNEIGTKEPTTNPETATTMLPSPSILVQTESTTAVGYHLKTVTVSFTISNLPYSAHMNNGSAVFNSTETVLKHLLEPLLHNGSFNSSCRLDSLRPEKNGTATAVEAICTYYHNAANSGIDTQELYSELSHLTYGITQLGNYTLDQESLHVSGYNEPHPEEPPTTPEPTTTMQPSPSTALHPEPTTGHHLKILTINFTISNLPYLSNMSNGSAMFNSTESVVQYLLSHLFQNGSFNSSCTLDSLRSRKNGTATGVNVICIYHHDPENPEMDIHGLYLEINNLTHGITQLGNYSLDNGSLYINGYNEHGVEELYTAPESPSTIVPSSSTFVKGEPTVAMGNLKTFTLNFTISNLPYSTDMSSGSAMFNSTERILQHLIRPLVQNESLYSNCRLASLRPKKNGTATGVNAICSYHQNPDHPELDTQELYTKLTQLTQGVTQLGSYMLDQNSIYVNGYTHQTAETTSSGYVPLNITIQGKYQLNFCIINWNLNNTDPTSSEYITLERDIEDKVTTLYTGSQLKEVFQSCLVTNMTSGSTVVTLEALFSSHLDPNLVKQVFLNKTLNASSHWLGATYQLKDLHVIDMKTSILLPAEIPTTSSSSQHFNLNFTITNLPYSQDIAQPSTTKYQQTKRSIENALNQLFRNSSIKSYFSDCQVLAFRSVSNNNNHTGVDSLCNFSPLARRVDRVAIYEEFLRMTHNGTQLLNFTLDRKSVFVDGYSQNRDDDVMKNSGLPFWAIILICLAVLLVLITCLMCCFLVTVCRRKKEGDYQVQRHRLAYYLSHLDLRKLQ
Protein: alkaline phosphatase (EC 3.1.3.1) (M9PD70)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP06402p
- GTP cyclohydrolase 1
- 6-pyruvoyl tetrahydrobiopterin synthase
- Thiamine pyrophosphokinase 1
- RE33762p
- Rad, Gem/Kir family member 3, isoform E
Sequence:
MRALRFFAALALQLTACSSQYKYGPEQSWDLDSISELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDGDVGKRLRVVMGGGTIKFLPNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLNNDAQNTDFLLGLFNASHLAYHMDDSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNVDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYAHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKARYSP