wanglab/gogpt-training-data huggingface dataset:
Protein: Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) (P52789)
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:29298880}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- Glucose-6-phosphate isomerase
- Hexokinase-1
- ATP-dependent 6-phosphofructokinase, muscle type
- Fructose-2,6-bisphosphatase TIGAR
- Hexokinase-3
- ATP-dependent 6-phosphofructokinase, platelet type
- ATP-dependent 6-phosphofructokinase, liver type
- Fructose-1,6-bisphosphatase 1
- GDH/6PGL endoplasmic bifunctional protein
Sequence:
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR
Protein: Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (TRAF and TNF receptor-associated protein homolog) (Q5XJA0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity). Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e-cadherin. Regulates the formation of Kupffer's vesicle, a signaling center essential for establishing L/R asymmetry. Modulates smad3 activity through modulating nodal-acvr1/akt4 signaling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O95551}. Nucleus, PML body {ECO:0000250|UniProtKB:O95551}.
Interaction partners:
- Tyrosyl-DNA phosphodiesterase 1
- Acyl-coenzyme A thioesterase 13
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- DDE_Tnp_1_7 domain-containing protein.
- Si:dkeyp-53e4.4.
- DNA-dependent metalloprotease SPRTN
- DNA topoisomerase 2
- Protein ILRUN
Sequence:
MSALGESRTRLCDQFAFVSGSDSAVAQCYLAENEWDMERALNSFFEAHMDSVFDEEAEKTEVTGNKRKDDTAEASGTKKKLKTDNADCIDLTAEEPTCSITVNSKENQAENGTAKSEVEDSKLSIISWNVDGLDTLNLADRARGLCSYLALYTPDVVFLQELIPAYVQYLKKRAVSYLFFEGSDDGYFTGIMLRKSRVKFLESEIICFPTTQMMRNLLIAQVTFSGQKLYLMTSHLESCKNQSQERTKQLRVVLQKIKEAPEDAIVIFAGDTNLRDAEVANVGGLPAGVCDVWEQLGKQEHCRYTWDTKANSNKTVPYVSRCRFDRIFLRSAKTAPPVTPDHMALIGMEKLDCGRYTSDHWGIYCTFNT
Protein: Sodium channel regulatory subunit beta-4 (Q8IWT1)
Organism: Homo sapiens (Human)
Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.
Interaction partners:
- Sodium channel regulatory subunit beta-1
- Sodium channel protein type 1 subunit alpha
- Sodium channel protein type 5 subunit alpha
- Sodium channel regulatory subunit beta-3
- Sodium channel protein type 4 subunit alpha
- Sodium channel protein type 2 subunit alpha
- Sodium channel protein type 11 subunit alpha
- Sodium channel protein type 7 subunit alpha
- Sodium channel protein type 10 subunit alpha
- Sodium channel protein type 8 subunit alpha
Sequence:
MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV
Protein: Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Q6DGM0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein eL42
- Ribosomal protein L26
- Large ribosomal subunit protein eL28
- Small ribosomal subunit protein uS11
- 60S ribosomal protein L7a
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS13
Sequence:
MPGRLWSKAIFAGYKRGLRNQREHTALLKLEGVYNRGEVDFYLGKRCAYVYKAKKKTATPGGKPNKTRVIWGKVTRAHGNSGMVRAKFKSNLPAKAIGHRIRVMLYPSRV
Protein: Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Q24055)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367101}.
Interaction partners:
Sequence:
DKHWAFSDIRTGRLLTKVIDTAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSNVANFPGHTGPISAISFSENGYYLATVADDA
Protein: Probable indole-3-pyruvate monooxygenase YUCCA11 (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA11) (Q9LPL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin biosynthesis.
Interaction partners:
- Tryptophan aminotransferase-related protein 1
- L-tryptophan--pyruvate aminotransferase 1
- Tryptophan aminotransferase-related protein 2
- Aromatic aminotransferase ISS1
- Aldehyde dehydrogenase family 3 member F1
- Indole-3-acetaldehyde oxidase
- Aldehyde dehydrogenase family 3 member H1
- Indole-3-acetaldehyde oxidase
- Aldehyde dehydrogenase family 2 member B7, mitochondrial
- Amidase 1
Sequence:
MEKEIKILVLIIGAGPAGLATSACLNRLNIPNIVVERDVCSASLWKRRSYDRLKLHLAKQFCQLPHMPFPSNTPTFVSKLGFINYLDEYATRFNVNPRYNRNVKSAYFKDGQWIVKVVNKTTALIEVYSAKFMVAATGENGEGVIPEIPGLVESFQGKYLHSSEYKNGEKFAGKDVLVVGCGNSGMEIAYDLSKCNANVSIVVRSQVHVLTRCIVRIGMSLLRFFPVKLVDRLCLLLAELRFRNTSRYGLVRPNNGPFLNKLITGRSATIDVGCVGEIKSGKIQVVTSIKRIEGKTVEFIDGNTKNVDSIVFATGYKSSVSKWLEVDDGDLFNENGMPKREFPDHWKGKNGLYSAGFGKQGLAGISRDARNIARDIDSLVCGRSSKNKLSK
Protein: Transcription factor Sox-17-alpha-B (xSox17alpha2) (Q90ZH9)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription activator. Binds to the DNA sequence 5'-AACAAT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q3KQ35, ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
Sequence:
MSSPDGGYGSDDQNQGKCSVPIMMSGLGQCQWSEPMTSLGEGKLKSDANSRSKAEGRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALSLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRAENGFMHMTEAQESAVMGTDGRMCLENFNLGFHEQTYPQLPQASHYREPQAMAPHYDGYSLPTPESSPLDLAEADPVFFTSPAQDECQMMPYSYNSSYTHQHNSGASMLVRQMPQTEQIGEGSPVEGMMACQSSPHMYYGQMYLPGSTRHHQHPQAGQPSPPPEAQQLGRADQTQQADMMAEDRTEFEQYLSYVSKSDLGMNYHGQESVGPTADNGPISSVLSDATTAVYYCNYPSA
Protein: Protein HIGH ARSENIC CONTENT 1, mitochondrial (AtHAC1) (Arsenate reductase) (EC 1.20.4.1) (Arsenate tolerance QTL1) (AtATQ1) (Rhodanese-like domain-containing protein 19) (Sulfurtransferase 19) (AtStr19) (Q8RUD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Arsenate reductase critical for arsenic tolerance. Reduces arsenate to arsenite in the root, facilitating efflux of arsenic back into the soil to limit both its accumulation in the root and transport to the shoot. Essential for arsenite efflux from the root, but not necessary for arsenate uptake.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Histone acetyltransferase HAC1
- Small ribosomal subunit protein mS29
- Dual specificity phosphatase Cdc25
- Histone acetyltransferase HAC12
- Histone acetyltransferase HAC4
- Histone acetyltransferase GCN5
- Histone acetyltransferase of the MYST family 2
- ACT domain-containing protein ACR3
- Tetraspanin-5
- Histone acetyltransferase of the MYST family 1
Sequence:
MYTYSLLNLSHCRRQTRKKRKTDHTEGFLMEETKPKTVEDVETVDVYTAKGFLSTGHRYLDVRTNEEFAKSHVEEALNIPYMFKTDEGRVINPDFLSQVASVCKKDEHLIVACNAGGRGSRACVDLLNEGYDHVANMGGGYSAWVDAGFAGDKPPEDLKIACKFRPKEN
Protein: Patatin-like protein 7 (AtPLP7) (EC 3.1.1.-) (Patatin-related phospholipase A IIIbeta) (pPLAIIIb) (Phospholipase A IIIA) (AtPLAIIIA) (Q9SV43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Catalyzes the hydrolysis of the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), and the phoshpolipids phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidic acid (PA), phosphatidylserine (PS). Favors the release of fatty acid at the sn-2 position for PC. Possesses acyl-CoA thioesterase activity. Negatively affects disease resistance to the necrotic fungal pathogen Botrytis cinerea and the avirulent bacteria Pseudomonas syringae by promoting cell death and reducing the efficiency of the hypersensitive response, respectively. However, PLP2 contributes to resistance to cucumber mosaic virus (CMV), an obligate parasite inducing hypersensitive response. May negatively regulate oxylipin production, possibly via participating in membrane repair that includes removal of oxidatively modified lipids. Enzymatic products of PLP2 may influence cellulose content and cell elongation.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21447788}; Peripheral membrane protein {ECO:0000305|PubMed:21447788}. Note=Associated with the plasma membrane.
Interaction partners:
- Peroxisome biogenesis protein 19-2
- Peroxisome biogenesis protein 19-1
- Patatin
- Phospholipase A I
- Phospholipase A2-beta
- Phospholipase A2-alpha
- Phospholipase D zeta 2
- Phospholipase A2-gamma
Sequence:
MHRVRNKPVKSTATASVKHLIKQRGGDGATAASKSANDYNNNDSLLTDMQEPSIDTDKLSYEIFSILESKFLFGYDDSKPEPANSVVAGSIKNQRGKICILSIDGGGMRGILPGKALAYLEHALKSKSGDPNARIADYFDVAAGSGIGGIYTAMLFGSRDGNRPIFKADDTWQFLTRNAKGLYGGAGILKRVLRTGSGCCSGTAKLKKVMKESFSELTLKDTLKPVLIPCYDLKSSGPFLFSRADALETDGYDFRLSEVCRATWAEPGVFEPVEMKSVDGQTKCVAVGGGLAMSNPTAAAITHVLHNKQEFPFVRGVEDLLVLSLGMGQLLDVSYEYDRIIKWKAKHWARPAALISNDGAADTVDQAVAMAFGHCRSSNYVRIQANGSNLGPWSPNMDTDPSGSNVNMLMGVAEEMLKQKNVESVLFGGKRIDEQSNFEKLDWLAGELVLEHQRRNSRIAPTVAFKQSVHRADQKTSDKDIGVTARER
Protein: Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (Q921I9)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NPD3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NPD3}. Nucleus {ECO:0000250|UniProtKB:Q9NPD3}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NPD3}.
Interaction partners:
- Exosome complex component 10
- Exosome complex exonuclease RRP44
- Exosome complex component RRP40
- Exosome complex component MTR3
- Exosome complex component RRP4
- Exosome complex component CSL4
- Exosome complex exonuclease RRP42
- Exosome complex component RRP46
- Exosome complex component RRP45
- Exosome complex component RRP43
Sequence:
MAGLELLSDQGYRIDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRSRALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVMDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDSRLHEDHLEQVLEAAAQAARGVHTLLDLVVRQHVQEASVSLGD
Protein: Popeye domain-containing protein 1 (Popeye protein 1) (Blood vessel epicardial substance) (Q9DG23)
Organism: Gallus gallus (Chicken)
Function: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Involved in epithelial movement during corneal sheet formation and regeneration. May play a role in VAMP3-mediated vesicular transport and recycling of receptor molecules. May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity. May be involved in skeletal muscle and heart development as well as in the maintenance of heart function (By similarity). May also be involved in striated muscle regeneration and in the regulation of cell spreading.
Subcellular location: Lateral cell membrane {ECO:0000269|PubMed:15277466}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000269|PubMed:16188940}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9ES83}. Membrane, caveola {ECO:0000250|UniProtKB:Q9ES83}. Note=Detected at points of cell-cell contact in confluent epithelial sheets. Colocalizes with components of the adherens and tight junctions. {ECO:0000269|PubMed:15277466, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:18493308}.
Interaction partners:
- Tight junction protein 1
- Ankyrin repeat domain-containing protein 10
- Caveolin
Sequence:
MDTTAISPLTPLGVIPDLKNATSVPFNETACENWKEIHHLVFHVANICFAAGLVIPTTLNLHMIFLRGLLTVGCALFIIWATLYRCALDIMIWNSVFLVVNLLHFIYLVYKRRPIKIEKELSSLYKRMFEPLHVPPELFQRLTGQFCNIQTLKTGQAYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMNRGEKFQVTIIADDNCKFLCWSRERLTYFLETEPFLYEIFKYLIGKDITNKLYSLNDPTLNDKASKKIDRQPSLCSQLSVMQMRNSMASTSDSEDGLQMFLRGTSSSSSLRPGRTSPYLRTSAKMKPIEESVEDDVFEAPSAEKLELQRLP
Protein: Photosystem I iron-sulfur center (EC 1.97.1.12) (9 kDa polypeptide) (PSI-C) (Photosystem I subunit VII) (PsaC) (P31087)
Organism: Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Function: Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
Subcellular location: Cellular thylakoid membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Photosystem I reaction center subunit III
- Photosystem I reaction center subunit IV
- Photosystem I P700 chlorophyll a apoprotein A2
- Photosystem I reaction center subunit II
- Photosystem I P700 chlorophyll a apoprotein A1
- Iron stress-induced chlorophyll-binding protein
- Photosystem I reaction center subunit XI
- Photosystem I reaction center subunit PsaK
- Photosystem I reaction center subunit IX
- Photosystem I reaction center subunit XII
Sequence:
MSHSVKIYDTCIGCTQCVRACPLDVLEMVPWDGCKAGQIASSPRTEDCVGCKRCETACPTDFLSIRVYLGAETTRSMGLAY
Protein: GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2) (Q96D21)
Organism: Homo sapiens (Human)
Function: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Interaction partners:
- Huntingtin
- Beclin-1
- Endosialin
- Plexin domain-containing protein 1
Sequence:
MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDKCTIQ
Protein: Actin alpha 2, smooth muscle (Actin, alpha 2, smooth muscle, aorta) (Actin, aortic smooth muscle) (Q6DHS1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Myosin, heavy polypeptide 11, smooth muscle
- Myosin, light chain 9a, regulatory
- Myosin regulatory light polypeptide 9b
- Myosin light polypeptide 6 isoform X1
- Zgc:153867.
- Myosin, heavy chain 9a, non-muscle
- Myosin, heavy chain 9b, non-muscle
- Myosin, heavy chain 10, non-muscle
- Transgelin
- Myosin, light chain kinase a.
Sequence:
MCDDEESTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
Protein: Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2) (Q9UGH3)
Organism: Homo sapiens (Human)
Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19379732}; Multi-pass membrane protein {ECO:0000269|PubMed:19379732}.
Interaction partners:
- Uridine 5'-monophosphate synthase
- Matrin-3
- Trifunctional purine biosynthetic protein adenosine-3
- Dihydroorotate dehydrogenase
- Vesicle transport protein GOT1A
- Vesicle transport protein GOT1B
- Metastasis-suppressor KiSS-1
- Dihydropyrimidine dehydrogenase [NADP
Sequence:
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG
Protein: S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS) (Q8Y7I9)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Interaction partners:
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Lmo1678 protein
- Cysteine synthase
- Lmo0845 protein
- cysteine-S-conjugate beta-lyase
- Lmo1680 protein
- Homoserine dehydrogenase
- O-succinylhomoserine sulfhydrylase
- L-threonine dehydratase
Sequence:
MAEKMNVESFNLDHTKVKAPFVRLAGTKVGVHGDEIYKYDVRFKQPNKEHMEMPALHSLEHLMAELARNHTDKLVDISPMGCQTGFYVSFINHSDYDDALEIIATTLTDVLVATEVPACNEVQCGWAASHSLEGAKALAEEFLAKRSEWKNVFGE
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (Aggrecanase-1) (Q8BNJ2)
Organism: Mus musculus (Mouse)
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- Brevican core protein
- Collagenase 3
- Stromelysin-1
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 3
- Collagen alpha-1
- Interleukin-1 beta
Sequence:
MSQMGLHPRRGLTGHWLQRFQPCLPLHTVQWRRLLLLAFLLSLAWPASPLPREEEIVFPEKLNGSSILPGSGVPARLLYRLPAFGEMLLLELEQDPGVQVEGLTVQYLGQAPEMLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASSQGPMCTVKAPSGSPSPISRRTKRFASLSRFVETLVVADDKMAAFHGTGLKRYLLTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEGPQVGPSAAQTLRSFCTWQRGLNTPNDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCTNLNGQGGSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPATFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGSSQACMGGRCLHVDQLKDFNVPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTENCPHGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDTSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSRCSKQSGSFKKFRYGYSDVVTIPAGATHILVRQQGGSGLKSIYLALKLSDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQNARLRYSFFVPRPVPSTPRPPPQDWLQRRAEILKILRKRPWAGRK