wanglab/gogpt-training-data huggingface dataset:
Protein: Non-specific serine/threonine protein kinase (Q38ES0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cdc23 domain-containing protein
- Anaphase-promoting complex subunit 11
- Cell division cycle protein 16, putative
- Cyclosome subunit 1, putative
- Anaphase-promoting complex subunit 2
- Dynein heavy chain region D6 P-loop domain-containing protein
- Rev7, putative
- E2 ubiquitin-conjugating enzyme
- Ubiquitin-conjugating enzyme E2, putative
- Uncharacterized protein
Sequence:
MKRCRAYFVGEVALTGVGAFQGRWCQPACKSQLQSTQKQGRPDGLTVSLMRLSASQRRTASVAYAHGNEERQLLPTSYKNVAAPRLLHVLLLKCRQKTAKPSILDVEAVPEVSMLAGAQRDADESGGKWHAAFRLFSEAIQRRGVLPNIAHINVLLGITVRERRWPQKAEVEKFVERFLEAAECMGDERKEYLAEQLQTGAKGNECTVDDVSIQQLITAMRPTAETYEWLMEAAVRQRDWEAALTYFGDARAACLPISDLSLRLSLRAYRIAGVHSIFKTTKRDRRAVQMMSLRTDQRGPALRSSAAPASLRGVANAVRVESEDVRYVWQAALSLFESYKHRVHEGQTIGLFMTMMTEAGQYQQVIRTHSECHRTLIVDEDVLLTVSRAARELGDWVLSLRLLEESSAKASGLPQSILENTVHTLRRTGHYREILLLHAQLPPIFWSAGAYVVLAQAAVVQRELPLLLSLLTDEEDRYEDAQMPHDVDTAAHTSLQRNLSFNVTTAASMCTGRQKQTPLEMFDVALRAIQVELIHRRCKRAGDSSTSTGSGSIGTGSGNCQAGSVTPRYDSVASLASLSVAIYEKFLHVSTRQLKKWERDNWPSGSTLTIYAPLLKLLAVPLCENHTVVSTNKNVRGSPCAPWEVALAHVALIRRPDAPLICLAAHLLQRYQQWEAAFKLLSHVEHNDELAQSAAFKLRCALQLGPSRASASVEPSSYRCTIISATSVRYAVLSAAAHRPAAALHLVQYALAHSWIDSGMALQLLQHIQRNMKEPVQRRTGGRQATASNSHIGMIGGETDSYTLSCDAIVFFKEFVSLWSQQSCVVAPLAPLFNEILIFLQRGPHTDPSISSFTALCGSIANVLRRLSTEWKVEQHADVELALVAAVHATVHHVGASTLSRRALWSECLCLVQLFHSPLIRRTYTVGVLEVNEATFRVLRTFISNCNRSEEAFVEGIAFQWLLPGKVLELPQLEEIFRAPGGLTSAANASVWWSLGLLLYSLVWASRLRSKELVRHFVGVLLPLLQRLLQNEGNCTIISTSVSPSEIRSDGLAAAVVAVQCLTSGAHEEVLHDWPHVYELLSTLLQVPELTATEKGEGNDVSTLADVLGAVLDKLRRSFHFLIRGVSLNKGYRTHCPKGPTTPASDRVKEHGTAEGNSSGEVVERSAFVFLDICEELTKRLSVGTNGERLVRNGITSCLDKVMNCIWDVGYALFVWRTLFSGYPNQVNAKVLQQLQSRYHRALYMQMLHLPVQHTTPSILERWLVVMSGCGRNGGTTRTHEESHENRLCAAIINDITTLDAWASCRSLPHEPGAHGRESRGREPLLIVPMVLRVINSITQAAMKRFSQCKLSHTKTCSKSWSGLLQLGGGRDVHSLFEDHLLVTTIQQLQTLQEAGSALVYMMLCEGNTEVLQMAPQIMSWYFCPRNVMHAVVHSMHSASPDVLKPLWKPEVLVAAFEALGVQSRMHAAEGISPPRLCVGSQASLLLSLLTSSSVVRAVARMDEEVIIAALLSLEAADLERSDNAQQTAHQLLVAFPKILERQLVPMLLRGHLGETQLHALDVIVERTASEVRKGSGTCSPALTRGAAMWMLLRRPSENRGARADGYDGLVESITMEERIFCNIMIFCGSQFEVNSCRAGAVQTQQRKRKQPAPREMRARNQFIPYALEWEQALKLLTDANKVELSDVVDVNGAFLDVIEMYGACVPMAWKVGFAKELLSHEAGCDDRHKGEVLPKVLVRDVARELLHCRSFAPGQPVDDRELYRVGLKIWSSLSTRRGALVQSPPSGVWNLVWRILNEMLRNRSPVHGRPAGLAEVSVLPFSLCVVERAVTHILRCGVRWSLLPGEREDIPTVAASLLLMLELIIPCRSLRLALFESDNITHEEGSDAPGCVAAITCEENSTGEHAVWSTLLSFEVLLLTLPGLLDGSSGAVPSCAAAKGQNALDVVTTLPRMLLYFACRHVSHLTSLGEDSARDRSGAAQEELGRLIELCGWHIASFSSALLTDSIKGEAPSTGKRLVLETAVKNFVRAALLMGTWRDIYWLAFRILACVKTLFAHGGRASKHPQMWGWVVGLLPAMVVASARTSSSIQVQVSTLIKEVPLDLLRLVPYGEVPTVNGLDNEEEVRIRQGVLSVLLRQVEQSIWLKTEEVLRERGRSLAFADRLSAVKPLVQLGMHLEVWKGNGARASSFLETLLFFLSERQFKLLCEASRVENRSKALSVRAVSPSERLPQKPEMTWEEALTLLLRSNRAEFCSFLQKSSSSSKSTTPKLHDALSIFKSSHISCCTPWWAAITLFCRSDGPPHVIHVFPAFFSERVIERCPSWKTALRALQHSSSTVPHTTRVQQYLVYLILRRLRTDPTWAIEESYTSAPTKLLGEHLSWQTACWCYDQLARKGKGAPPIQQRTMTELLRHCVLNPEATLSMYEVYWAQGYNRAEGVNSFLSLLRAGRRGNSEKLVLRAMRDYIKQCDEWNGAQCNTQRRKIKSPPFTAEGNATLCRAFLSVCSGGIVSQQARTEVAAALKQRGCIGEVEELLIVSGCSEGARPRDT
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.27) (A0A0U3RBN1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU367105}.
Interaction partners:
Sequence:
MRPVQRNFYDPSSSPGKGIVWEWENDCGSWTPYDMELCVSIQNAYEKQHPWLDLSSLGFSYLVDFDSMSQTNRQSQRKRRIRRRMDLAYPLIAGSIPKSQSWPVGTNSGTPCTCQQCLLVHSTRAASNAILALQQRRKLYGTEGGANQNTSTVRQSNTFAGSPLWSPTTTIARGHHNNHNNISVGGGGGGKAEMNGANFPLVTLPTNHALTINGQNNLNRPGTQRITVTASRGAVPAGVPALPVKNLTGPGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVNKSDLKPVPGINSIRRKTKKKHLRKGKSPEDVVRRYTEKIKCAPEEDCTICMERLSSASGYEGVLSCKSIKPELVGKLGKCGHLYHLLCLVAMYNNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEYHIIPHSLPGHSDIKTIRIVYDIPAGVQTTEHPNPGKKYSARGFPRHCYLPDNEKGRKVLKLLITAWDRRLIFTIGTSSTTGESDTVVWNEIHHKTEFGSNLTGHGYPDPKYLDNVMRELEAQGVGEDNLKDE
Protein: Gamma-adducin (Adducin-like protein 70) (Protein kinase C-binding protein 35H) (Q62847)
Organism: Rattus norvegicus (Rat)
Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (By similarity). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA. Promotes the growth of neurites (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7592723}. Cell membrane {ECO:0000269|PubMed:32029431, ECO:0000269|PubMed:33308016}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250|UniProtKB:Q9QYB5}. Note=Full-length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q9QYB5}.
Interaction partners:
- Alpha-adducin
- RCG25684, isoform CRA_a.
- Tropomodulin-1
- Ankyrin 2
- Tropomodulin-2
- Tropomodulin 4
- Dematin actin binding protein
- Ankyrin-3
- Protein 4.1
- Calmodulin-like protein 4
Sequence:
MSSDTSQAVITTPPPPSMPHKERYFDRINESDPEYLRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHDPTGLLALQQIADYIMANSFTGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTYISVRVSKEQDHIIIIPRGLSFSEATASALVKVNIIGEVVDQGSTNLKIDHSGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERIELQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLLILDLQKYKAFTHGVAMTGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLVREKPRHKSDVEIPATVTAFSFEDDSVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDPSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMRFEDDDQGPPAPPNPFSHLMEGELEEYTKTIERKQQGLDDAEQESLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSVDVPVIVNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPDRTEEVLSPDGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA
Protein: 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) (P77488)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Interaction partners:
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase
- Farnesyl diphosphate synthase
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- Isopentenyl-diphosphate Delta-isomerase
- Thiazole synthase
- Exodeoxyribonuclease 7 small subunit
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
Protein: Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) (O73792)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Angiopoietin 2b.
- Angiopoietin 1.
- Angiopoietin 2a.
- Angiopoietin 4.
Sequence:
QLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRMQEARKAYVNMALFENFTYAGIDATAEEA
Protein: TNF receptor superfamily member 10b (A0A0G2JZE1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member.
- FAS-associated death domain protein
- Caspase-8
- Tumor necrosis factor ligand superfamily member 6
- CASP8 and FADD-like apoptosis regulator
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Receptor-interacting serine/threonine-protein kinase 1
- Tumor necrosis factor receptor superfamily member 6
- TNF receptor-associated factor
- Tumor necrosis factor
Sequence:
MLQAFLLLSFFVPVTAKLAQDRPADLQRLKQSPLECPAGQYLSKEDGSCKACIDGENYTSGPNVLPSCLSCRVCKEDKVIKSRCVKARNTECECKPGSFEDKDSTEICQTCSNCTDGEDEVIPCTPKANRKCVPKNTQIPQHNLGLIIGLLASVISVVLFVAVIWKTKAWESVCLFMTRVYPGCEQDHENTVGLSLLDAQTSRKTNGSHHNTEPDRTQSSPLGRKLLVLANGNNPADALKLIFERCSTEVPFNSWDRLMRHMGLTDNQIQMVRAETQVPCEVLYQMLLKWLYQTGLGASINHLLGALEAVGERCALEEIEDYAVKSGKFVYQNTTA
Protein: Uncharacterized protein C777.11 (O74550)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Glutamyl-tRNA
- Glutamyl-tRNA
Sequence:
MPFLKPSKVSLKRILQGNPPKPIGLTEYGHLLRLVGLREADSKEENERTILKLNEGIIQMHAIERLDTSFIKEPFRTLNHAINAESLPSLPDQEPWNVFQNAKKRDGQYFAVYSKLKDDSSNESPNKQ
Protein: LD18233p (PSEA-binding protein 95kD) (Q9VHX0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- snRNA-activating protein complex subunit 3
- PSEA-binding protein 45kD
- TATA-box-binding protein
- Transcription initiation factor IIA subunit 1
- Transcription initiation factor IIA subunit 2
- Transcription initiation factor IIB
- TBP-related factor
- Transcription initiation factor IIA subunit 2-2
Sequence:
MDDADDLRINQQQLMDEISALLQNTAKPSAANALQLNQELQRRLMQVRTKILAMLQVVRARFSRNEDILVRRLRPRSHFGPNSLNLSGAILRKGTFRFKGNLFFRDIDGRSCPNNEDYEARCHTEMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLLEHRAHSTNALPSGSLKRKPIERHLSTLVSLLATADSSFSIDWNQISTLDLEYRHSPYSCEAMWRVYLTPDLRRDDWSPEEDETLLAVATANRMQNWELIAASLDRRSDYQCFVRFHTALRFLLEPKNSHRWSEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHEPFTTKEDMMLFAAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTDSWSVQDDTRLMSFVTQYGASQWLNCATFLGNHTRTSCRTRFLVIKKFLEQNPNAKVEDLPRRRSKKVSLVNSDNWAQRLQEWQEDPESLVNDNPPKGTRVRGPKSKKARIERQAESFSRLSKVDIEFCNFFKFSYNLTLSTPKTFPVPKDVYNLAYVIRALAYKPPIRPSLLQNIFMPNDVLKCYNSMIRNLPDEEGDMKSPLLPPNWSTMMGFRALCILSGDCRKDTETRSFEYNESLPPIQLFRKRLQALFYRTTLLSRLESQLFTDLPSALVSLPRPKHDYAKMGTHVELIDPEPAPQNDLKSEPLSENEVINTVKQELEMEYTVP
Protein: Trehalase (EC 3.2.1.28) (Alpha-trehalose glucohydrolase) (N1P7X5)
Organism: Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast)
Interaction partners:
Sequence:
MSQVNTSQGPVAQGRQRRLSSLSEFNDPFSNAEVYYGPPTDPRKQKQAKPAKINRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQGNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYKHINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQFWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQASQMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLIGYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYGKILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASIKEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPYASKHGVTLDEFKQLYNDGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYEIDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESGFFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGGLAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRLAYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAATEGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
Protein: Potassium channel subfamily K member 7 (Q9Y2U2)
Organism: Homo sapiens (Human)
Function: Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Keratin, type II cytoskeletal 2 oral
- Potassium channel subfamily K member 18
- Potassium channel subfamily K member 12
- Potassium channel subfamily K member 13
Sequence:
MGGLRPWSRYGLLVVAHLLALGLGAVVFQALEGPPACRLQAELRAELAAFQAEHRACLPPGALEELLGTALATQAHGVSTLGNSSEGRTWDLPSALLFAASILTTTGYGHMAPLSPGGKAFCMVYAALGLPASLALVATLRHCLLPVLSRPRAWVAVHWQLSPARAALLQAVALGLLVASSFVLLPALVLWGLQGDCSLLGAVYFCFSSLSTIGLEDLLPGRGRSLHPVIYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSGPVTAEDQGGILGQDELALSTLPPAAPASGQAPAC
Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (Q5U1Z5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: Protocadherin 10 (E9PXQ7)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
- Actin-binding protein WASF1
Sequence:
MIVLLFFALLWMVDGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFRVEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGGGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGMSVFTYVSINSDNGYLYALRSFDYEQIKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGGDRGGGSGEHLRPSRSGGGETSLDLTLILIIALGSVSFIFLLAMIVLAVRCQKEKKLNIYTCLASDCCLCCCCCGNGSSTCCGRQARARKKKLSKSDIMLVQSANVPSNPAQVPVEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDAEHNPCGAIVTGYSDQQPDIISNGSILSNENKHQRAELSYLVDRPRRVNSSAFQEADIVSSKDSGHGDSEQGDSDHDVTNRGQSAGMDLFSNCTEECKALGHSDRCWMPSFVPSDGRQAADYRSNLHVPGMDSVPDTEVFEPPEVQPGAERSFSTFGKEKALHGTLERKELDGLLSNTRAPYKPPYLKMLWMQLRGEAHLTKDGGKQTTT
Protein: Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) (Q9NSK0)
Organism: Homo sapiens (Human)
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Kinesin-1 heavy chain
- Kinesin light chain 1
- Kinesin light chain 2
- Kinesin light chain 3
- C-Jun-amino-terminal kinase-interacting protein 3
- Glycogen synthase kinase-3 beta
- C-Jun-amino-terminal kinase-interacting protein 1
- Calsyntenin-1
Sequence:
MSGLVLGQRDEPAGHRLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSRGQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVKFEGGEDASVAVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLNQPSAAPLQVSRGLSASTMDLSSSS
Protein: Uncharacterized FAD-linked oxidoreductase Rv2280 (EC 1.-.-.-) (P9WIT1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable oxidoreductase
- Malate synthase G
- Putative isocitrate lyase subunit A
- Putative isocitrate lyase subunit B
- Isocitrate lyase
- D-amino-acid oxidase
- Isocitrate dehydrogenase 2
Sequence:
MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATPEEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEVDTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARHNVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILASGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQTVGEMLMELGAVDAYVLEGGSARKLIEAREKAFWAAKALGADDIIDTVVPRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTDIFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGDT
Protein: Probable UDP-3-O-acylglucosamine N-acyltransferase 1, mitochondrial (EC 2.3.1.191) (Protein LIPID X D1) (AtLpxD1) (F4JGP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21709257}.
Interaction partners:
- Probable lipid-A-disaccharide synthase, mitochondrial
- Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 2, mitochondrial
- Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 3, mitochondrial
- Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 5, mitochondrial
- Probable 3-deoxy-D-manno-octulosonic acid transferase, mitochondrial
- Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 1, mitochondrial
- Probable tetraacyldisaccharide 4'-kinase, mitochondrial
- Probable acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, mitochondrial
- Is a member of the PF|00364 Biotin-requiring enzymes family
- At5g19070
Sequence:
MANSLRTLFSVSTHGVFLNKRSSYRVRKVFVGMPLRICSEIPRFVSVSCIRSDMCGIMMLGKDVHDLLETSSGGNVEKGFLRWRNGGGMYHRSALIDSSALVEFGAVVHQEAILGAEVHIGSNTVIGSSVKIGPSTKIGNCSIGDLCVIHNGVCIGQDGFGFYVDDNGNMVKKPQTLNVKIGNRVEIGANTCIDRGSWRDTVIGDDTKIDNLVQIGHNVIIGKCCLFCGQVGIAGSAEIGDFVALGGRVAVRDHVSIVSKVRLAANSCVTKNITEPGDYGGFPAYKKTEPDSAFASDKHCFILQKILIQVPIHQWRRQIVEAQISSKRKP
Protein: Countin-1 (Q86IV5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion.
Subcellular location: Secreted {ECO:0000269|PubMed:10444594}.
Interaction partners:
- Starvation responsive small protein A
Sequence:
MNKLFSLILALFLVNSAVVSSLDSCSICVDFVGNSLNDLLNIILNSGVIGTCGDLCSAVPGGQIVDTVCDLLCDYVGVDEFIKLISDVDPDPIYICEKISVCKTNDNAAASLDLVQINPQNGTVGGTFTLSIAYTVTNTIATGQLAFNIIDPTGNAFGDAVLLVQQSPEQYTQQFQFQATPSEQESFPNGLYTVQALVCEGSCGSPHPNTYTLANGTTTFTISGADSSSMSGAGSFSGSSQSTQTGAASGSGSGFALF
Protein: Protein ATP1B4 (X,K-ATPase subunit beta-m) (X/potassium-transporting ATPase subunit beta-m) (Q9BDK6)
Organism: Sus scrofa (Pig)
Function: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:14656723}; Single-pass type II membrane protein {ECO:0000269|PubMed:14656723}. Note=Detected in nuclear envelops.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha.
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta
- cGMP-dependent protein kinase
- SNW domain-containing protein 1
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MRRQLRSRRAPAFPYGYGYRLDDQDEVNQNYLADEEEEAEEARVMVVPDLEEEEKEEEEEKEEDEKEEEESHHQDTRSAWWQKLQIVNEYLWDPEKRMSLARTGQSLSLLLVIYFFFYASLAAVITLCMYTLFLTISPYVPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGDEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGIINDVINDRFVGRVIFTLNIET
Protein: Methyltransferase N6AMT1 (HemK methyltransferase family member 2) (Lysine N-methyltransferase 9) (EC 2.1.1.-) (Methylarsonite methyltransferase N6AMT1) (EC 2.1.1.-) (Protein N(5)-glutamine methyltransferase) (EC 2.1.1.-) (Q6SKR2)
Organism: Mus musculus (Mouse)
Function: Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (By similarity). It however only plays a limited role in arsenic metabolism compared with AS3MT (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16684535, ECO:0000269|PubMed:19116772}.
Interaction partners:
- Multifunctional methyltransferase subunit TRM112-like protein
- N
- Peptide chain release factor 1, mitochondrial
- Mitochondrial translation release factor in rescue
- Peptide chain release factor 1-like, mitochondrial
- Nicotinamide phosphoribosyltransferase
- F-box only protein 5
- Eukaryotic peptide chain release factor subunit 1
- Nucleic acid dioxygenase ALKBH1
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
Sequence:
MAAPSVPTPLYGHVGRGAFRDVYEPAEDTFLLLDALEAAAAELAGVEICLEVGAGSGVVSAFLASMIGPRALYMCTDINPEAAACTLETARCNRVHVQPVITDLVHGLLPRLKGKVDLLVFNPPYVVTPPEEVGSRGIEAAWAGGRNGREVMDRFFPLAPELLSPRGLFYLVTVKENNPEEIFKTMKTRGLQGTTALCRQAGQEALSVLRFSKS
Protein: Nematogalectin B (Nematogalectin precursor) (E0D8Q4)
Organism: Hydra vulgaris (Hydra) (Hydra attenuata)
Interaction partners:
Sequence:
MRVQQGLLCLSVFFLVLLIDVSLSQQAGRILPDWPRIGDRITQPFLDQLMVSQLLEQNLTLGFFLKGLNGPPGPPGPPGPAGEPGPPGLPGAPGAPGHVGEDGAPGPMGPPGQPGLPGPPGYPGEKGDPGMTGLPGAAGLPGAPGLPGPQGPSGDSAPEAIMPNFTVICEGEKGWLQCKQYELIKVKNAFWGRDDQITCPKVPAGLDNARLCDTNPENTIAKVNGQCKNEQACEVVASNIFFDDNSCGNVYKYLKIWYECIPDESNAVDVLREGGRRKKKRAAKEKRSFRDS