wanglab/gogpt-training-data huggingface dataset:
Protein: NADH dehydrogenase, NDH-2B (Ndh2-2) (A7LKG5)
Organism: Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) (Bacillus pseudofirmus)
Interaction partners:
- Peroxiredoxin family protein
Sequence:
MTMKYVIIGGDAAGMSAAMQIVRRNKDADVTTLEMGEYYSYAQCGLPYAVGGLVKGGLDDLVARDVETFRSKYGIDARVNHEVTHVDTEKKLVSGKDFSVPYDKLLIATGASPIVPDWDGADLDGIHTVKTIPDTEAVIKDMHNDTHHIAVIGGGYIGLEMAENFVEQGKKVTMIERGPQLAGIFDQEMANLIHEEAEKHGVKLLFNEEVKGFKGDSRVEEIVTDKQSFKVDMVIVAIGVKPNTHFLEDCGVHLHENGAIQVNGYMETNIPDVYAAGDCATQYHRIKEHDDFIPLGTHANKQGRIAGLNMAGDSRTFKGIVGTSIMKFFSLTLGRTGLSLREAEELRIPTEIVDAEIPHHATYYPGSEILTIRLMYQRHTEQLLGAQIIGKEGVDKRIDVLATALYHKMTMEDLENLDLAYAPPYNGVWDPIQQASRRRG
Protein: tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (E7EQB3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR017250}.
Interaction partners:
Sequence:
MRRMLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLMPEEARLLAEIGAVTLVSAPRPDSRHHSLALTSFKRQQEESFQEQSALAAEARETRRQELLEKITEGQAAKKQKLEQASGASSSQEAGSSQAAKEDETSDGQASGEQEEAGPSSSQAGPSNGVAPLPRSALLVQLATARPRPVKARPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDFLVYPGDPLRFHAHYIAQCWAPEDTIPLQDLVAAGRLGTSVRKTLLLCSPQPDGFKSQEVSINLVYKCS
Protein: Cathepsin D (EC 3.4.23.5) (P18242)
Organism: Mus musculus (Mouse)
Function: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
Subcellular location: Lysosome. Melanosome {ECO:0000250}. Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Cathepsin B
- Lysosome-associated membrane glycoprotein 1
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- BH3-interacting domain death agonist
- Lysosome-associated membrane glycoprotein 2
- Procathepsin L
- Cathepsin S
- Angiotensinogen
- Lysosomal protective protein
Sequence:
MKTPGVLLLILGLLASSSFAIIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPKTTEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQLEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEYMIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGSYYTVFDRDNNRVGFANAVVL
Protein: Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) (P53805)
Organism: Homo sapiens (Human)
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
Interaction partners:
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Calcineurin subunit B type 1
- Glycogen synthase kinase-3 beta
- PPP2R1A-PPP2R2A-interacting phosphatase regulator 1
- Nuclear factor of activated T-cells, cytoplasmic 1
- Calmodulin-1
- Calmodulin-like protein 3
Sequence:
MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS
Protein: Probable xyloglucan endotransglucosylase/hydrolase protein 27 (At-XTH27) (XTH-27) (EC 2.4.1.207) (Q8LDS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity). Required for cell wall modification during the development of tracheary elements.
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Glycosyl transferase family 1 protein
- At1g10020
- AT5g66920/MUD21_18
Sequence:
METLSRLLVFMSLFSGLVSGFALQNLPITSFEESYTQLFGDKNLFVHQDGKSVRLTLDERTGSGFVSNDYYLHGFFSASIKLPSDYTAGVVVAFYMSNGDMYEKNHDEIDFEFLGNIREKEWRVQTNIYGNGSTHSGREERYNLWFDPTEDFHQYSILWSDSHIIFFVDNVPIREVKRTAEMGGHFPSKPMSLYTTIWDGSKWATNGGKYGVNYKYAPYIARFSDLVLHGCPVDPIEQFPRCDEGAAEDMRAAQEITPSQRSKMDVFRRRLMTYSYCYDRARYNVALSECVVNPAEAQRLRVYDPVRFGGIPRRHRNGKHRSKRSRVDGTESI
Protein: Transducin-like enhancer protein 4 (Enhancer of split groucho-like protein 2) (ESG2) (xESG2) (Grg-4) (XGrg-4) (Groucho-related protein 4) (O42478)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional corepressor. Functions with ripply2.2/bowline to down regulate transcription of tbx6-dependent gene expression. Represses transcription of siamois and nodal3.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MIRDLSKMYPQTRHPAPPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHAHGLPVPLTPHPSGLQPPAIPSIGSSAGLLALSSALGGQSHLPIKDEKKHHDSDHQRDRDSIKSSSVSPSASFRAAEKHRNSTDYSSESKKQKTEEKDIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKPRLLKKDAPISPASIASSSSTPSSKSKEHSHNEKSTTPVSKSNTPTPRTDAPTPGSNSSGLRPVPGKPPGVDPLTGLRTPMAVPCPYPTPFGIVPHAGMNGDLTSPGPAYASLHSISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPGIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
Protein: Amino acid permease 4 (Amino acid transporter AAP4) (Q9FN04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Amino acid-proton symporter. Stereospecific transporter with a broad specificity for neutral amino acids, favoring small amino acids such as alanine, asparagine and glutamine. Accepts also large aromatic residues such as in phenlalanine or tyrosine.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- WAT1-related protein At1g44800
Sequence:
MDVPRPAFKCFDDDGRLKRSGTVWTASAHIITAVIGSGVLSLAWAIGQLGWIAGPTVMLLFSFVTYYSSTLLSDCYRTGDPVSGKRNYTYMDAVRSILGGFRFKICGLIQYLNLFGITVGYTIAASISMMAIKRSNCFHESGGKNPCHMSSNPYMIMFGVTEILLSQIKDFDQIWWLSIVAAIMSFTYSAIGLALGIIQVAANGVVKGSLTGISIGAVTQTQKIWRTFQALGDIAFAYSYSVVLIEIQDTVRSPPAESKTMKIATRISIAVTTTFYMLCGCMGYAAFGDKAPGNLLTGFGFYNPFWLLDVANAAIVIHLVGAYQVFAQPIFAFIEKQAAARFPDSDLVTKEYEIRIPGFRSPYKVNVFRAVYRSGFVVLTTVISMLMPFFNDVVGILGALGFWPLTVYFPVEMYIRQRKVERWSMKWVCLQMLSCGCLMITLVAGVGSIAGVMLDLKVYKPFKTTY
Protein: Protein inhibitor of activated STAT, 4 (F7F3J5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus, nuclear body {ECO:0000256|ARBA:ARBA00034306}.
Interaction partners:
Sequence:
NPPEVWENMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYPVLYGKYLNGLGRLPTKALKPEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECEDADEIEFLAEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGMGSGLSGPGGAGGGAGAAGGLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDDDEGPRPKRRCPFQKGLVPAC
Protein: 14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed] (P61983)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:11427721}. Mitochondrion matrix {ECO:0000250|UniProtKB:P61981}. Note=Translocates to the mitochondrial matrix following induction of MALM (mitochondrial protein catabolic process). {ECO:0000250|UniProtKB:P61981}.
Interaction partners:
- 14-3-3 protein epsilon
- Serine/threonine-protein kinase A-Raf
- M-phase inducer phosphatase 2
- RAF proto-oncogene serine/threonine-protein kinase
- 14-3-3 protein zeta/delta
- WW domain containing transcription regulator 1
- M-phase inducer phosphatase
- Bcl2-associated agonist of cell death
- Forkhead box O3
- Transcriptional coactivator YAP1
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (C0HK70)
Organism: Zingiber officinale (Ginger) (Amomum zingiber)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8L5E0}.
Interaction partners:
Sequence:
MVKAVAVLGSSEGVKGTIYFVQEGDGPTTVTGSITGLKPGLHGFHVHALGDTTNGCMSTGPHFNPAGKEHGAPEDENRHAGDLGNATAGEDGIVTVSVVDSQIPLSGPNSIIGRAVVVHADPDDLGKGGHELSKTTGNAGGRVACGIIGLQG
Protein: Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) (P51906)
Organism: Mus musculus (Mouse)
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12119102, ECO:0000269|PubMed:18684713, ECO:0000269|PubMed:30840898, ECO:0000269|PubMed:9233792}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Apical cell membrane {ECO:0000269|PubMed:26739563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Synapse, synaptosome {ECO:0000269|PubMed:30840898}. Early endosome membrane {ECO:0000269|PubMed:30840898}. Late endosome membrane {ECO:0000269|PubMed:30840898}. Recycling endosome membrane {ECO:0000269|PubMed:30840898}.
Interaction partners:
- Excitatory amino acid transporter 4
- PRA1 family protein 3
- Disks large-associated protein 3
- Amino acid transporter heavy chain SLC3A1
Sequence:
MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVLGVVVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIVSSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNDINRTGKTPEVSTMDAMLDLIRNMFPENLVQACFQQYKTKREEVKPVGDPGGNATEVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLIVLPLLYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGLDLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALEPTTLDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
Protein: Lon protease homolog 1, mitochondrial (EC 3.4.21.53) (P93655)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17478548, ECO:0000269|PubMed:19076295}.
Interaction partners:
- At1g64880
- ATP-dependent Clp protease proteolytic subunit 2, mitochondrial
- B3 domain-containing protein At3g06220
- Pentatricopeptide repeat-containing protein At1g43980
- Putative pentatricopeptide repeat-containing protein At2g01510
- ATP-dependent zinc metalloprotease FTSH 3, mitochondrial
- Large ribosomal subunit protein eL24z
- Cell differentiation, Rcd1-like protein
- Subtilisin-like protease SBT1.6
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
Sequence:
MLKLFTSSASRVHHLTPVSRVVGSSPVESPLFKALSQITGWNRRSTSLGHRAFFCSEPTNGEAAAEAETKAVESDSEVSDSKSSSAIVPTNPRPEDCLTVLALPVPHRPLFPGFYMPIYVKDPKVLAALQESRRRQAPYAGAFLLKDDPSADSSSSTDAEKNINELKGKELLNRLHEVGTLAQISSIQGDQVILVGHRRLRIKEMVSEEPLTVKVDHLKDNPFDMDDDVVKATSFEVISTLRDVLKTSSLWRDHVQTYTQHIGDFTYPRLADFGAAICGANRHQAQEVLEELDVHKRLRLTLELMKKEMEISKIQETIAKAIEEKISGEQRRYLLNEQLKAIKKELGVETDDKSALSAKFKERIEPNKEKIPAHVLQVIEEELTKLQLLEASSSEFNVTRNYLDWLTILPWGNYSNENFDVARAQTILDEDHYGLSDVKERILEFIAVGRLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRKFFRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHAGDPASALLELLDPEQNANFLDHYLDVTIDLSKVLFVCTANVIDMIPNPLLDRMEVISIAGYITDEKVHIARDYLEKTARGDCGVKPEQVEVSDAALLSLIENYCREAGVRNLQKQIEKIYRKIALKLVREGAVPEEPAVASDPEEAEIVADVGESIENHTVEENTVSSAEEPKEEAQTEKIAIETVMIDESNLADYVGKPVFHAEKLYEQTPVGVVMGLAWTSMGGSTLYIETTVVEEGEGKGGLNITGQLGDVMKESAQIAHTVARKIMLEKEPENQFFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLATKKPVRKDLAMTGEVTLTGRILPIGGVKEKTIAARRSQIKTIIFPEANRRDFDELAENVKEGLNVHFVDDYGKIFELAFGYDKQED
Protein: 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) (Q9Y7M1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Peroxisome matrix {ECO:0000250|UniProtKB:P39994}.
Interaction partners:
- Probable acetolactate synthase small subunit
- Peroxisomal targeting signal receptor
- Phosphatidylglycerol/phosphatidylinositol transfer protein
- FAD-linked sulfhydryl oxidase erv2
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Hydroxyacyl-thioester dehydratase type 2, mitochondrial
- Probable citrate synthase, mitochondrial
- Dihydroxy-acid dehydratase, mitochondrial
- Mitochondrial 2-methylisocitrate lyase
- Protein sly1
Sequence:
MSISFSELVAKTLLDLEVKVVFGIVGIPVIEICEAIQASGIRFVGFRNEQSAAYAATAYGYLTQRPGVCVVVGGPGVVHAMAGVFNSKTNRWPLLLLAGSSETFQQNCGAFQELDQVSYLSPHTKLAVRPPSPKMVVDSIRRAYRVSMTGTPGTCYVDLPANYIESTVDDFPKDPLPPIPSSPKCAPDPTQLQKAAYYLKNAKAPLLVVGKGAAYACAEKQLLEFVEHTGIPFLPSPMGKGLLPESHPLNVSSARSAALRNADVVLLAGARLNWIFQYGLPPKWSPNAKFIQIDTNAETLGNNAADLDLAIWADVGLTIDCLFKLVQTWKYSVGISTPYLRTLNETRSKNEKKALESRKSSIPLQMNYALYVVNEELQSLSLKSKRNITWVSEGANTMDRGRQLLEVTHPRGRLDAGTMSTMGVGMGYAIASAFAHSSDKIVVVEGDSAFGFSAMELETAIRNQLDLLVIVINNNGVYHGLDTDAYETLRDNHQLPTTALGTSIRYDQICEACGGKGFFVKNEEDLRSSLRKAWQTSSVSLINVMVDPEAARKLTFAWMSSTKVKPKL
Protein: Cation transporter (Q38B51)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKARRRGGSLHAELPFTYTLFSTIDVYGDDLLDFTGDDKPERHAEVTEFLRRRGSGACRDAPLGPSSYLHMREPFSYIAEGSISENTSDAGGSFARVEDAMQHVWFISQRDGISTPFALNFSTSAQFLRYAERESLQFPTLRCGSSTMASEPIAAHEGPAKWLDIQTKNKTLVTDILSHFPVSADTVEHCCYPDDMDRVIAHSTLGYFFFNLMCTPIALGEVARGRHQVKSVIQQRLEAAMSAGPRSSTPSAVAVSVIVFFDWVVTVHEEPFHEFDDLLRFILINCGNRAPASNNRRLMQVMTAPFIFASFFQIVVGHLLDSESLTMIVDEVSDLVFLSKSTEGHNEEVVQRITNARRCFAEYAAELTRREYIASVLLHSHMMDSFLTKDKVCRTQIESAQAYLYRMSDEVGDCRDTVALTNWYQNVKDTWHHLQYGNKALRQTVLFTELINIMYPLITLQTLFSLNVRIPFAYYEDQMEKDLKPFFIMMGIVLFFLLLCGRAMYALWHKKHWSTRLLAT
Protein: Gustatory receptor for sugar taste 64c (P83295)
Organism: Drosophila melanogaster (Fruit fly)
Function: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Gustatory receptor for sugar taste 43a
Sequence:
MQQSGQKGTRNTLQHAIGPVLVIAQFFGVLPVAGVWPSCRPERVRFRWISLSLLAALILFVFSIVDCALSSKVVFDHGLKIYTIGSLSFSVICIFCFGVFLLLSRRWPYIIRRTAECEQIFLEPEYDCSYGRGYSSRLRLWGVCMLVAALCEHSTYVGSALYNNHLAIVECKLDANFWQNYFQRERQQLFLIMHFTAWWIPFIEWTTLSMTFVWNFVDIFLILICRGMQMRFQQMHWRIRQHVRQQMPNEFWQRIRCDLLDLSDLLGIYDKELSGLIVLSCAHNMYFVCVQIYHSFQSKGNYADELYFWFCLSYVIIRVLNMMFAASSIPQEAKEISYTLYEIPTEFWCVELRRLNEIFLSDHFALSGKGYFLLTRRLIFAMAATLMVYELVLINQMAGSEVQKSFCEGGVGSSKSIFS
Protein: IP16409p (RH25118p) (Supercoiling factor, isoform A) (Q9W0H8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Calreticulin
Sequence:
MARTRIQMLLLVVALTAVISGASASSIPEELPHNPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDESKKFDSLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNETISWDSYMQTVYGFMDDLSPDEKEQEENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEFTAFLHPEDHPSMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTHRDLDKDGYLNEEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDFGEALARHDEF
Protein: Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Q6E804)
Organism: Bos taurus (Bovine)
Function: Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages. Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon. Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9HC29}; Lipid-anchor {ECO:0000250|UniProtKB:Q9HC29}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9HC29}. Cytoplasm {ECO:0000250|UniProtKB:Q9HC29}. Mitochondrion {ECO:0000250|UniProtKB:Q9HC29}. Note=Palmitoylation promotes localization to the cell membrane, where it detects bacterial invasion at the point of entry. {ECO:0000250|UniProtKB:Q9HC29}.
Interaction partners:
- Receptor-interacting serine/threonine-protein kinase 2
- Autophagy related 16 like 1
- Mitochondrial antiviral-signaling protein
- NLR family pyrin domain containing 1
- Autophagy protein 5
- Angio-associated migratory cell protein
- Ubiquitin-like protein ATG12
- Toll-like receptor 2
- Caspase recruitment domain family member 9
- Toll-like receptor 9
Sequence:
MCAQDAFQTQRSQLVELLVSGSLEGFESILDRLLSREVLSWEDYEGLSLVGQPISHLARRLLDTIWNKGTWGCEQLTAAVREAQADSQPPELPSSWDPHSPHPARDLQSHRPAIVRRLYGHVEGVLDLTQQRGFISQYETDEIRRPIFTSSQRARRLLDLATVKANGLAAFLLQCIQELPVPLALPFEDAACKKYVSKLRTVISAQSRFLSTYDGAENLCLEEVYTENVLEIQMEVGMAGPSQQSPTTLGLEELFSTRDHFNKEADTVLVVGEAGSGKSTLLQQLHLLWASGRAFQEFLFVFPFSCRQLQCLVKPLSMRTLLFEHCCWPDLGPQDVFQVLLDHPERILLTFDGFDEFRFRFTDQERHCCPTAPTSVQSLLFNLLQGNLLKNARKVLTSRPSAVSASLRKHVRTELSLKGFSEEGIELYLRKRHREPGVADRLLCLLRATSALHGLCHLPVFSWMVSKCHEELLLQGRGSPKTTTDMYLLILRHFLLHASPLPLATHGLGPSLIQGRLPTLLHLGRLALWGLGTCCYVFSAKQLQAAHVDSEDLSLGFLVLAKRVVPGSTAPLEFLHITFQCFFAAFYLALSADTPPSSLRHLFQDHRPESSPLARVLPKLFLRGSRCREGSVAALLQGAEPHNLQITGAFLAGLLSQEHRSLLAECQASETALLRRWDCVRRCLTRSLREHFRSIPPALPGEAKSMHALPGFLWLIRSLYEMQEERLAREAVCRLNVGHLKLTFCGVGPAECAALAFVLRHLRRPVALQLDHNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLVEHALRCEQLQKLALFNNKLTDGCAHSMARLLACKQNFLALRLGNNHITAAGAEVLAQGLRTNNSLQFLGFWGNQVGDEGAQALAAALGDHQSLRWLSLVGNNIGSVGAQALALMLEKNMALEELCLEENHVQDEGVCFLAKGLARNSSLKVLKLSNNHISSLGAEALLRALEKNDTILEVWLRGNTFSPEEIEKLSHQDTRLLL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9XWQ5)
Organism: Caenorhabditis elegans
Interaction partners:
- CCM gene homolog
- mitogen-activated protein kinase kinase
- Programmed cell death protein 10 homolog
- Kruppel-like factor 2
- Integrin Cytoplasmic domain-Associated Protein homolog
- Dual specificity mitogen-activated protein kinase kinase mek-2
- Ras-like GTP-binding protein rhoA
Sequence:
MAVSSMNEKQKLRKKVEVLARACNNYEQLVDKCRKTTNLDMFRILYEMGKYEMVIDGQKTLDEAIKHNGKKLVVEFVLQKYEEDTVRVKTGNIITVSEPDEIEPEPNIVMKALMDSLPNTNDLDRQSYAGTLAGRSYGLPSQASRYSEKLPSIPRRYSLGKLIGRGTLGSVYLAEGKKGGTYAVKIISKHGRHLPQEADVEYLRMLRHVRIVEYLYIIEPSKSNDIHILMEYMHTGSLQEYIARTGPLHHELVKAYAKQILEGLEFLHSKNIIHQDLKPANLLLKNTHRERLIKIADFGSSRFSSLKREREGQQGRTPKYTDPGVSLGRHVSGRRSDIWSLGVIIIEMYTGVYPWSIDGEHPITVPRILDENPPNFTTSEKIDENLIKMAKLMLQSVAKRPYASTLLELPILQESSENEDEDSDDDDDYF
Protein: ANK_REP_REGION domain-containing protein (VAB-19) (G5EDN8)
Organism: Caenorhabditis elegans
Interaction partners:
- Microtubule-actin cross-linking factor 1
- SH3 domain-containing protein
- HECT-type E3 ubiquitin transferase
- Kinesin-like protein klp-12
- Kinesin-like protein klp-19
Sequence:
MRDIGGSMSSASTSATIVKRSPPNDTSTSSGVSCDVSPNSMTSPSSGSDQNQNNNSLNKCKCCPYGYHIDLGFVSYAQNVSNGFVSRQGTPTNMTLRGNGADRHLMSPLLDNSIFSDSLDNLMSDFDDVLAPHKEVEKKKTVQDIRSRMQGGYNSDYTTYRRGPPEIPRRAHFEQAKPPPLSRPINLGFSGSRSNTPTQRFNAPNGTGNGYSTALAKTISEIRARNAESPFPDSRVGTPIDLGLHQQNNGHVTPSRFANNRYDDLPPTPTPTFRRAPSQGDLPRGFSTAPSTGPGDFASLRRGREFALPPEQEHHSRRFFSASPKLPRRGLQAGPSIDVESHFTYAQTQNGQKVLARTQSTSTSPPPQAPASAFEPVKPLSNGSPSPTHQVQKPIVTRSIAVSTGPLPAPKPCGECAGLRKELFLAVEKIPPPPPESCHVSTSTVLLEFADQSVGSEPIKHCHVALGTEPTSTREVGTVPVTVRSLHIDTQTDPAASTVDAACSPVLFETQEEAVKVTVAASSSAAAADCEECLKRQDVFTRNVGVGACSISDKICVSCDNQVVEADENEAPGFKTDTKDDQKQRDFEIAKANAVKKLLTNEQKSNFQRGTAVSKSARYDRKRSVDDLDYIVDKKNATSPATSSQEAPPTVPDASESPLTTKVVLKKEVFIEPPKQMLPDPIPARIPRPKISKWAVTSEEEAAETPDEQEEAQDRLTPLRSDMRQLGNRWNRNQVTTASNTTPHLPYSGATSQEDVSDSDAESDCSAHSDATFEVNDDVFDAAPFEVSDRLREALENFNSSILEPGSVAEETVEWSAKLVRHVWMTTAGNSSSRYENVDRFVAELGNLGPQILHMVVNFCDQNGNTALHYAVSHANFAVVSSILDSGECDLDAPNRAGYTAVMLAALSQLDDDMEKAVVHRLFQMGNVNAKASQHGQTALMLAVSHGKKTTTELLLACGANVNEQDQDGSTALMCAAEHGHKELVKMLLAENLVNASLTDVDNSTALSIALENDHREIGVMIYAYLNYGRLDISGPTSTI
Protein: Ethylmalonic encephalopathy 1 isoform 1 (Ethylmalonic encephalopathy 1, isoform CRA_b) (A0A0S2Z5B3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA
Protein: Antitoxin VapB47 (P9WF23)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47.
Interaction partners:
- Ribonuclease VapC47
- Diacylglycerol acyltransferase/mycolyltransferase Ag85A
- Resuscitation-promoting factor RpfB
- Phosphate-specific transport system accessory protein PhoU homolog 2
- Uncharacterized PPE family protein PPE42
- Hypoxic response protein 1
- Ribonuclease VapC35
Sequence:
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRTLSDVLNEMRDEQ