wanglab/gogpt-training-data huggingface dataset:
Protein: Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) (P55087)
Organism: Homo sapiens (Human)
Function: Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29055082}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Cell projection {ECO:0000250|UniProtKB:P47863}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. {ECO:0000250|UniProtKB:P47863}.
Interaction partners:
Sequence:
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV
Protein: Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PXR) (Pregnane X receptor) (O54915)
Organism: Mus musculus (Mouse)
Function: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Retinoic acid receptor RXR-alpha
- Nuclear receptor coactivator 1
- Cytochrome P450 3A11
- Nuclear receptor subfamily 0 group B member 2
- Cytochrome P450 2B10
- Ectonucleoside triphosphate diphosphohydrolase 8
- Cytochrome P450 7A1
- Cytochrome P450 3A
- Nuclear receptor corepressor 2
- Cytochrome P450 1A2
Sequence:
MRPEESWSRVGLVQCEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKDRVPMKISLQLRGEDGSIWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG
Protein: H2-M2 protein (B2RWS1)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
METSAFFTLLFTLYLLLGASLALAQTFRGSHSLRYFDIAVSRPGLEETHYMTVGYVDDTEFVHFDNEAENPRFEPRVPWMEQMGQKYWDDQTRIAKAAEQQIRVYFQKLRDYYNQSQNSSHTIQRMTGCYIGPDGHLLHAYRQFGYDGQDYLTLNEDLSTWTAADAAAEITRREWEATNVAEFWRVYLEGPCMVWLFKYLTVGNETLLRTEPPKAYVTHHPRPEGDVTLRCWALGFYPSDIIMIWQRDGEDQTQDMDVIETRPAGDGTFQKWVAVVVPSGKEQNYTCHVAHEGLPEPLTLRWNLLSLSFSS
Protein: Transcription factor zip1 (Q10424)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mediates cell growth arrest in response to cadmium exposure, which is essential to maintain cell viability. Regulates cadmium stress specific genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:16823372}.
Interaction partners:
- F-box/WD repeat-containing protein pof1
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase polypeptide 5, mitochondrial
- Cytochrome c oxidase subunit 13, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 6B-like protein new16
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome b-c1 complex subunit 7
Sequence:
MDFTPNSAINHLNLKFDDVPVSDDFSKDDLAEQLNVFTNPYFLDLEPSSMLSEGYYGFVSQPSGSSNSNKQEKNVQQQNPEKISTLQQVKEEEVSNTFSAPLNATGNFSSANPASIDLAYLDLQKLLTLPDHSKETQEKTSSQRELFEQKSSVASASKDNVSSSSILQGSASSKLLPDQSARQHQVLVGQTAIPTSEASSSINNTPLQAPVSSFADQNAFTNPLSTFASPDLASVSSPSLSSYKGAQSPNANSKRTKATSAIRTAAEEDKRRRNTAASARFRIKKKLKEQQLERTAKELTEKVAILETRVRELEMENNWLKGLIRPTSNF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q6FRH8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P22219}; Lipid-anchor {ECO:0000250|UniProtKB:P22219}. Endosome membrane {ECO:0000250|UniProtKB:P22219}; Lipid-anchor {ECO:0000250|UniProtKB:P22219}.
Interaction partners:
- Vacuolar protein sorting-associated protein 30
- Phosphatidylinositol 3-kinase VPS34
- Serine/threonine-protein kinase ATG1
- Vacuolar protein sorting-associated protein 38
- Autophagy-related protein 18
- Ubiquitin-like protein ATG12
- Autophagy-related protein 3
- Autophagy protein 5
- Autophagy-related protein 8
- Autophagy-related protein 9
Sequence:
MGGQLSLLAQTAPSIGIFSYIDILDETHYVSQLNNSRFLKTCKALDPNGEIVVKVFIKPKEDSSLEKIIQRLKREAVLLSALPNVLNYSKIFESTRCGYLVRQHLKTNLYDRLSTRPYFTEIETKFVVFQLLQALKDIHDLDVIHGDIKTENLLLTSWDWVVLSDFCSNIKPAYIPDDNPGEFSFYFDTSKRRACYLAPEKFDSAKASGDGVHQATKEMDIFSLGCCIAELYLDGAALFNLSQLFKYKSGDYTLNDILPQTISKSSPVLKDILQDMLQVDPKKRLSAHELLEKYRTIYFPDTFYDFLYDYCKTLVTLGTSVPCADQIEVNTTLQDHLGSIDEILIKIYCDFGRICKSLKLPVLDQEDMNYNTKDSFLRVSDKLLRLENYETDKITASIQNEVSLIILVFLCKEFRNLQFPENKVKALQLILAFSLFVLDDTKLDRTLPYLVAALEDDSTRVKVMAMNCVTTLIKEVKHPNQLNENIFVDYLLPRVQALLQNGQEESLVRVAIASNLSDLALKANLFQEYCHTMQSSTIPNIVHDFESIEVIRKYSRKLQQLFEDLTVSILTDPEISVKVALLKNILPLCKYFGREKTNDVILSHLITYLNDRDPALRMYLVECISGIAILLGPITMEQYILPLIIQTITDEEELVVVSVLKNLKDLLKTRFVNKKYFYDITKFLSPLILHPNSWIRNFVLTTLVECINQMSKAEVYCVLYPVLRPFFDFDVDFTGDMLISCAKLPVSRNTYNLLRSWNNRSKKTFFWQRVTTNYVDAFGNSTINFVDKRYVKENYGLKTMKVESNIHLHTNENENIPLTLEDKFWIDKFKNSGLTDNELWKIVALREYVVRSSRSSSKKPETVTSIVSKLSLTPSNFSIENVMPNTVFFDIEFLHPETLTFNDLDVTNTNSIKESESNTFTDNHSKVIEMKGSLIFKTPRIPTTLSNLKNIYVQLEPTNNHSEGHAHLSARNQPANFIVKSSYEGQDKIIEKYLKQLNILPSLKEYKEFGFVSENTTAEADVINLHGKFVRSYPQIFDGTLLQSEVLLGTKSFMIYGSDQGALTVWDIDRLANEKSITRPLYYECSAEITCIKGLSGYDSFCVGLKSSEILIFRISLSKNGKAKNLQELICIRSLNLIGENSSEYPIQIECCPNNDQFQLVVLSNYSNVYLFDIRTMKVIEKLELNADYGCTISMVLDDKNNLLFFGTVSGIIEMWDARYFVQIRAWTFGESLPINKLAIMEQENKSLLVVCGGVDSAFFTLWNIEKLSCKHVFVRSNEQPSLDSFNVIDADKLDKLAFEKNNSNIKPIVQIFNNKVLYMDDIGRLLHILDTRNPEKSSTFAGSKVELHSFSVLQVTASLTMSLQKHNYQKEVNNSNYTSSRVMTVNVFQLKNKPYMLLTDEEGYINIYT
Protein: U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) (P08621)
Organism: Homo sapiens (Human)
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:17656373}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373, ECO:0000269|PubMed:21113136}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376}.
Interaction partners:
- Small nuclear ribonucleoprotein F
- U1 small nuclear ribonucleoprotein A
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D1
- Serine/arginine-rich splicing factor 1
Sequence:
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE
Protein: Transcription repressor OFP8 (OVATE family protein 8) (OsOFP8) (Q94CV1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcriptional repressor that regulates multiple aspects of plant growth and development, partly through brassinosteroid (BR) signaling pathway. Acts downstream of the kinase GSK2, a negative regulator of BR signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:27332964}. Cytoplasm {ECO:0000269|PubMed:27332964}. Note=Phosphorylated OFP8 shuttles from the nucleus to the cytoplasm where it is degraded by the proteasome. {ECO:0000269|PubMed:27332964}.
Interaction partners:
- Shaggy-related protein kinase GSK2
Sequence:
MSGRSSRRGSFSLRQPPVVDIGCNCRRPKLFSIFSSSSSSSFRRGGSKPKSPNASSTSTTTAFTATTGGAGTATSTDSSWGPASFTTNSLFEEPAAAQQEQEQLETRRRRRQQRRRRRRAGATSFARGGDVGGHDDEQQQLQEQAPYRRVAKESVAVAVESAEPYEDFRESMVQMVVEKEIYAWDDLNDLLHQFLSLNSPRHHPLILHAFADLWTRNGLFSPPSPCQF
Protein: SD02860p (Q960G6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSILSCGPQMAFSVSQRSCLPSHQVHSSDRVQFWQEVQVQTTYTSQDLRGNVKSQLSSLRSCPPNVQKNYPYPFHAGHYVRCQYGALEIICCPTGQLYSLSQRQCVPRSLLSAHDYLDYSYISAELSTEFMVDRSTLSCPPQAQGLYLHPFDCTKYVRCWNQQTFIESCTPGEIFSFSNQKCVPKEQCKGPTDHVEYLIETTTVTTYDSDGPESASSLAKTGDISCPPGASGNHAHPFDCTKFLECSNGQTFVKNCGPGTAFSTAKHICDHANQVDCSGRSSLPGQSQVTQNNIATSYPSKPLDILPILKTSPPSYPHAEHLTDLFCPSGVNGQFVHPFDQTKFLLCQAGKLAVQSCQSGYVFSISKSICQPKTQLVYSDYVTYKVSVISIDQTMILSACPDGTNGLHLYPYDAGKYVRCSDGGKMSIQSCENQMAFSLSQRACRPSRLVSTEDRVRFREELQIQTTYSSQDIHIQQSPLKECPSVLRGNYPYPFHAGHFVNCQNGHLQIVSCPPTALYSLSQRECVVRQLLSPHDYLDYAYISVQLSTNIIHDTTALSCPPQAQGYYLHPFDCTKYIVCWEKQTHIESCPQGEAFSISQQKCVARDKITQAYDRVEYLEDTQHELSHEEADEEEQTEPESNLSLDGGNQPPGKYQAPYYSNGGYPTPSQNNGGYQTPSQNNGGYQEPSQNNGGYQPSYQGNEGYTPTYQNPFEGYHQPNQSSYQTNGGYQPPLPPHGGYQPPSQTYGGFQQPNRTYEDFHNPSQTVGGFQPPYSVKGGYQPHNQLNGGYNQPNQSSSFQANGGYQPPSQVNRGYQTSFESNGGYQPPLETNKGHQIPSQINGGYQPRVDGNRGYQPPNELNGGYQPPNELNGAYPAPSQLNGGYQPPVEGNLGYRPLSQQNSAYQPPQPSTGAYQPPFQSTGSGHYPGQDAPYAIPTPLLCPEKVSGLFPNPFDATGYLTCIDGHTLPRQCQPLDVFSVSQGYCLPEQHVNKTDRVPFERTQTYQDNSLDCPRDFLGFVVYPFDCSKYLSCGPSGMKLLNCPGEQHYSISHGFCKPVDQVQREDRLYTINELHIIFEWTQKMMIVGAVTACPEGITGTLPHPRVPTKYLRCGPGQAEMYDCPSQQIFSVSRRVCVLDDKLSSYDRTDYLVRGVNSGWMDPSNDNRQSKSYETSGRDQFGNRYTTRTTTTTRVIGDRWTDMNMQRPSGVGVEQNPHHHHHGYNPGWSGQETSYVQRGPTQSTLYVEGSLQPNRNYPTNKTPLAPMAPTNTGGVYYGQPVEDKENVPSRQNYSRRIDYGSPGNGWKPMPPLDPLGGQQPLNLDYSPHSPGAKEPQSQDSLPGQKPINLDYDEEPIPQYLHNGLPPYPGSPPRFYPDQLPSGSKPIGRQQPVESSPDASGYPDQQKPLDPDNGLHGSKVPPRHSPNPGYPLYNESNLYGGLLPPKPDSPNTTPTPTPNPSSSQAPTPQLANRLHTFPIYPPVDNKTSLRNPIQPHYSPSYAGIAHSRDAPWAKVPVTSTTPAQDPDPFNPELDEPFYDDVDFLTTTVRNVLVPPPFDHKFYSPQSTNPSINRNQSASGPNSQAAIKEALKLMLRPYFNHSGNAQEQLAQQAESAIVSVISKPSTTTTTTPRPTSKTPKTDPDFDAELIKAGEQESLDSVDDDYVFPDARETSRTEQTLDPSTTYASTNFQRSTRRAELDPDTLTATTMKTNWHAPGHSRDYHRRHPNLPDPFTEHHPNSSPHQHQHHHRHPHEHSADFHLRHPELPNPFPLKNETPQHQDLNDDWDLLPNSNAEEVTPKLATRSSFNTQCDFDCGNGQCLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAKIEKNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQRYSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQRGRHPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCLYGSPKGAYFVRVGDHYANIAESSEVDSFIENWYLHENFRKGTHMNNDIALVVLKTPLKFSDYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMDESVDACEGDSGGPLVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYEKINESLLRF
Protein: Ankyrin repeat domain 27 (A0A8I5ZNY3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFSSFQAVLIEGNRVKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKRETSEEPSAPSDPFSLKTIKDVREFLGRHSERFDKHIASFHRTFRECERKSLRHLIDSVNALYTKCLQQLLRDSHLKVLAKQEAQMNLMKQAVEMYVHHDIYDLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRELGQLNKCTSPQQKLLCLRKVVQLMTQSPSQRVNLETVCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSSPKDELGYCLTSVEAAIEYIRQGSLSAQPPDAEGFGDRLFLKQRMNLLSQMSSTPIDCLFKHIASGNQKEVERLLSQDDQDKDAMQKMCHPLCSCEDCEKLVSGRLNDPSVVTPFSRDDRGQTPLHVAALCGQASLIDFLVSKGAVVNATDYHGSTPLHLACQKGFQSVTLLLLHYKANTEVQDNNGNTPLHLACTYGQEDCVKALVYYDVQACRLDIGNEKGDTALHIAARWGYEGIIETLLQNGAPTAIQNRLKETPLKCALNSKILSAMEAYHLSSDRRPKPSEVPAPSPTRSADSISQGSSTSSFSSVSVSFRPEEVKKDYREVEKLLRAVADGDLEMVRYLLEWTEDDLDDMDEAISTVDLEFCHPLCQCPKCAPAQKKLARIPANGLSVNVTNQDGFSPLHMAALHGRTDLVPLLLKHGAYSGARNTSQAVPLHLACQQGHFQVAKCLLDSNAKPNKRDLSGNTPLICACSAGHHEVAALLLQHGAAINACNNKGNTALHEAVMGRHVLVVELLLFYGASVDILNKRQYTAVDCAEQDSKIMELLQVVPSCVAASPNNVVVVQETEHEDYVTVEIRKKWNPKMYNLPEEPFRRQFCLINPGGRFQERTKSWETMGRDRSVPDLTGGLQEPEKQRVTGKQNDLSDQSRCQTSEEGNKGLPGRPVPRQAVPGHRPMVRRHTVNDAAILQVPEVTGHLTTQEAGVSRS
Protein: Perilipin-1 (Lipid droplet-associated protein) (Perilipin A) (Q8CGN5)
Organism: Mus musculus (Mouse)
Function: Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:O60240}. Lipid droplet {ECO:0000269|PubMed:23481402, ECO:0000269|PubMed:24945349}. Note=Lipid droplet surface-associated. {ECO:0000250|UniProtKB:O60240}.
Interaction partners:
- 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
- Hormone-sensitive lipase
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Lipid transferase CIDEC
- cGMP-dependent protein kinase 1
- cGMP-dependent protein kinase 2
- Caveolin-1
- Adiponectin
- Patatin-like phospholipase domain-containing protein 2
Sequence:
MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKETAEYAANTRVGRLASGGADLALGSIEKVVEFLLPPDKESAPSSGRQRTQKAPKAKPSLVRRVSTLANTLSRHTMQTTAWALKQGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQSEVRVPWLHNLAASQDESHDDQTDTEGEETDDEEEEEESEAEENVLREVTALPNPRGLLGGVVHTVQNTLRNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPSAEAERKGSGARPASPESTPRPGQPRGSLRSVRGLSAPSCPGLDDKTEASARPGFLAMPREKPARRVSDSFFRPSVMEPILGRAQYSQLRKKS
Protein: Endoplasmic reticulum transmembrane protein (Q8LDS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367026}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367026}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MALQWLILSYVVAVEVVITLVLTLPYPMLLKKRVVQLVSLILQPAASIVAFAGFQLLDIYWKAEHRLSCSSEVCTATERDRYEKSIYKAQRNVVLCAAGILLYWCIYRICKYNKDLERLEATEKRFKEE
Protein: Norrin (Norrie disease protein homolog) (P48744)
Organism: Mus musculus (Mouse)
Function: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Frizzled-4
- Low-density lipoprotein receptor-related protein 5
- Tetraspanin-12
- Leucine-rich repeat-containing G-protein coupled receptor 4
- Adhesion G protein-coupled receptor A2
- Ubiquitin-like protein FUBI
- Low-density lipoprotein receptor-related protein 6
- Catenin beta-1
Sequence:
MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS
Protein: Alpha/beta-Hydrolases superfamily protein (Q8VYT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGGVTSSIAAKFAFFPPTPPSYEVIADDSCGGRLYIPEIPRRDDVDILKLRTRCGNEIVAVYVKHSKANGTLLYSHGNAADLGQMFELFVELSNRLRVNLMGYDYSGYGQSTGQASECNTYADIEASYKCLKEKYGVKDDQLIVYGQSVGSGPTVDLASRTPNLRGVVLQCPILSGMRVLYPVKCTYWFDIYKNIDKIGSVTCPVLVIHGTADEVVDWSHGKRLWELSKEKYEPLWISGGGHCDLELYPDFIRHLKKFVVSLGNKQAEQAPT
Protein: EP1-like glycoprotein 3 (Curculin-like (Mannose-binding) lectin family protein) (Putative receptor-like protein kinase-like protein) (Q9ZVA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in a cell-to cell programmed cell death (PCD) signaling mechanism.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:12833529, ECO:0000269|PubMed:18796151}.
Interaction partners:
- Cytochrome b-c1 complex subunit 6-1, mitochondrial
- Probable leucine-rich repeat receptor-like serine/threonine-protein kinase At3g14840
- glucose-6-phosphate 1-epimerase
- Polygalacturonase inhibitor 2
Sequence:
MKFSITLALCFTLSIFLIGSQAKVPVDDQFRVVNEGGYTDYSPIEYNPDVRGFVPFSDNFRLCFYNTTPNAYTLALRIGNRVQESTLRWVWEANRGSPVKENATLTFGEDGNLVLAEADGRLVWQTNTANKGAVGIKILENGNMVIYDSSGKFVWQSFDSPTDTLLVGQSLKLNGRTKLVSRLSPSVNTNGPYSLVMEAKKLVLYYTTNKTPKPIAYFEYEFFTKITQFQSMTFQAVEDSDTTWGLVMEGVDSGSKFNVSTFLSRPKHNATLSFIRLESDGNIRVWSYSTLATSTAWDVTYTAFTNADTDGNDECRIPEHCLGFGLCKKGQCNACPSDKGLLGWDETCKSPSLASCDPKTFHYFKIEGADSFMTKYNGGSSTTESACGDKCTRDCKCLGFFYNRKSSRCWLGYELKTLTRTGDSSLVAYVKAPNANKKSTL
Protein: Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (G5EAT2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 20S-pre-rRNA D-site endonuclease NOB1
- Low-temperature viability protein ltv1
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S14
- 40S ribosomal protein S7
- 40S ribosomal protein S6
- Uncharacterized protein
- 40S ribosomal protein S3
- Serine/threonine-protein kinase RIO2
- Pre-rRNA processing protein Tsr1, putative
Sequence:
MSSDSTTQAASPAEGLNPSHTYVPNKGYANEDGAVPAMAGQDLTPEDEDYEGDEYYDDIFEEELDEGDFNSSNPADLTKAYNRQRRVNELAADPNAPKWTYPKTNTQKPTVNTYASVDDEIKSLTRHAAKIKLDNVQSGLAVRGGSGTDRADRATSEQVLDPRTRMILLQMINRNIVSEIHGCLSTGKEANVYHAMLQPEDDFDAAPIHRAIKVYKTSILVFKDRDKYVTGEFRFRSGYNKSNNRAMVKLWAEKEMRNLRRIYAAGIPCPEPINLRLHVLVMGFVGNSKGIAAPRLKDVDFNISDPESKWRELYIDMLGYMRVMYQTCHLVHADLSEYNTLYHNDKLYVIDVSQSVEHDHPRSLEFLRMDIKNVSDFFRRKGVPTISERVIFEFIISAEGPATVTDELRDAVEKLFSLEPEAADEVDTAVFRQQYIPQTLDQVYDYERDAEKVNAGEGDDLVYRDLLAREKPSAPPDDEAETGSEVSGGVSIAESGSEDEEERDPFEKKPPRGKRFEDKESKKEHKNKVKEEKREKRANKMPKHLKKRLVSSSSRKRK
Protein: Peroxidase (EC 1.11.1.7) (Q08671)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU362060}.
Interaction partners:
Sequence:
MRKIMGAKVLFFFALLSFSAVSAFAQDEEDQGLVMNFYKDSCPQAEDIIKEQVKLLYKRHKNTAFSWLRNIFHDCAVQSCDASLLLDSTRRSLSEKETDRSFGLRNFRYIETIKEAVERECPGVVSCADILVLSAREGIVSLGGPYIPLKTGRRDGRRSRADVVEEYLPDHNETISGVLDRFAAMGIDTPGVVALLGAHSVGRTHCVKLVHRLYPEVDPALSPDHVPHMLHKCPDQIPDPKAVQYVRNDRGTPMVLDNNYYRNILDNKGLLIVDHQLAYDKRTRPYVKKMAKSQDYFFKEFSRAITLLSENNPLTGSKGEIRKQCNLANKLH
Protein: Forkhead box P3 (D4Q8I2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Runt-related transcription factor 1
- Signal transducer and activator of transcription 3
- T-cell surface glycoprotein CD4
- Interleukin-2
- RAR-related orphan receptor C
- Mothers against decapentaplegic homolog 3
- Histone acetyltransferase KAT5
- Cytotoxic T-lymphocyte protein 4
- Nuclear factor of activated T-cells 5
- Nuclear factor of activated T-cells 2
Sequence:
MWQFPTSQADPSLSVHFTQVSVPALPHQTQLCWRKWQGRSVRSPPVQPDTLQPASDKNLMPNPRPAKPMAPSLAPGPSPGGLPSWKTAPKGSELLGTRGPGGPFQGRDLRSGAHTSSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHGHTPVLQVRPLDNPAMIGLPPPTAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKAFEEPGEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALTKAPPVASVDKSSCCLVATSTQGSVLPAWSSPREASDSLFAVRRHLWGSHGNSTFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPSKCSNPCP
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (A0A2R8Y5Z6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGVKKTSVLPSERKVGGPESPSYFLPDTYHLGVCKEPVLNFQTDQRRLAQLRELRAKFFLS
Protein: Heat shock protein family B (small) member 6 (A0A1X7SC65)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYR
Protein: DNA polymerase (EC 2.7.7.7) [Includes: 3'-5' exodeoxyribonuclease (3'-5' exonuclease) (EC 3.1.11.-)] (P06856)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral OPG148/A20 and OPG116/D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform OPG116/D4synthesis across an abasic site.
Interaction partners:
Sequence:
MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVYLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA