Protein: Leashin (Q4X212)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Acts as the tether and is essential for anchoring of Woronin bodies at the septal pore. In damaged hyphae, Woronin bodies occlude septal pores in order to separate intact from damaged compartments.
Subcellular location: Cell septum {ECO:0000269|PubMed:23869404}. Note=Localizes to the central part of the septum indicating a specific targeting to the rim of the septal pore. {ECO:0000269|PubMed:23869404}.
Interaction partners:
Sequence:
MFRALMGGGRSSDSRSTTSSSKSSSRRRTNSKASSTVSRKSSRGDDRDRGLGDLSAYSFSGSRSKRYAPSAAGDSVASSYATAEPGIAVEHDRIIIERTLKRRDTDEESGRDRYSEIRDRDGRSSRRRDRDRSQSRERERPRSERIERAQLEDDAVESRDRRRERSRTQPGDTYLPPVSPSMPIQPNSPLVYDPHVQQQFPGQFPAYVAEPYRPPNPAGEAADYYGDQGQSVADQPGVRPKPPPIIPSSQAHLMTASPVANPPPEPSSMGQVGAAAAYFADDAELEVDPAPGRPDRPTAGTTSEPPKPSNTTFGISGIAAGAAAYGAGGSLPLPASPTSPPEPVPTTAPYAPPVTSSTTKPPHTHGIGASVGAAAAGAAAGYMLGHHQHHSMSSADHLSQYTMQNYDESSQYGLGIPGPTVYNAPANAEWHAAGTGTAVPYAASPLHPHHAAVHHGAPFPSGSLAFQQRQRGPLDKFIDFWRDPEGVGMFEEYTEAIGVCKYCFEPGTSSRDAPRKHHYRQRRSSGERYASGSRVGKASRYTSSEDEGRRRKKSSRNSWLLPGLLGGIAAKALFNNKDFEDTYSVRSGRVMTVKDTESVSTARRSQTSRGVYRRRSQSRDRESRIIYSDSKSQYEDKRHRSRSRSHSSSRNRRHSALRDAAVGAAVGSGAIALAKSRDRSRSRSRSRSRFPRKSKGRKSSTSDSSSFLDISQPARKSVGGGIASFFTASSENRGKRRVKKRRSIFSFNNSSSSSLDADLAFGTGFARKPARKSTKKSSKKKDRDVDAALLGLGAAATALAATSHRRSRRAGEILVAKETRSRHSDYASSVTNDEGWEDLDSGDQSSSSVSSALAFGDTGLFGSDESQSSDSGTSKWGWRWGSKKNKKKKRASSPQGRFPTGAALAAGALGTAALASTQDRDSRLPRQHASSSSGSLQHVAPVPTNDPTLVDAVRVASLPHAEPAFVRPGPIPLQQPQPMTPVSQAVYATQGASIPTYAAPMAPPAFPPTSYIPYRPEQIQNVALGFNRPHHRSDSSPVFHTEPLEGVPAPGLKRRSTSKDQSSVQFDLTKEQADKERRMDRLEQLKRDAERASGVQLIDRDHEPTVRDDDRRSGRYEDRGYVDRRQDEPREDRYAMDSGKDKDSFSRVGAVAAGSIGAAAAATVLSGRSSVDESSETSQRRHEERRQQRRAERRRGSEPESAVSSRSKSERAQETTDYLPEERQPEPTKPPSPSRSPHKYDDYAEFFAPEELRYSPDTYKQRAPTSMPTIVEIEPASERQSREALLPAEESHPGYRDLPWPVPVLKLIEPTPPQSVSGSVRDAASPVGNPRDLPPHEEEEDVKPAARQTTGSRVSWGEHKTHEYEVPSTSSELESVDHETTREREQPHSPVLQQRYVSPKNAADDVGADIEFAAALAAATAAAGFNPALVTEDPTYHTWSSPPGSHGRVEYRDPWVETESKSRIPHGFVEGEVETPEEEKAPSSRVIEEQPLYSEPEPVSREPESQESSEPQTRTSIAQEVIDRLSEKQDERDGSRKALYGTEKSSNSGKERDESELRAQDSFSMPGGFETEELRSDPKRDVDSRDDGDVDRRSVASAPVSGEYDFSTRPRKSTQDSEYFDNGEDAGSASIEQDGSEGKKKRRKRRSKRDSDTFTDSASVESSPARIGQSSEKLKSMDDKDKEKKAGGFFSSIFGSRVSEPVDSKRSSSTDRPSRDVHSEIGRREYEESRRQRKEEKSSRRDEESGSDKENSKVRDKDGVDIENYKSSRQRREERRRRRYEDIVDSGKSGEYEKDRKLSEDNDENQSFLAEGPEMPAQIGDGDRGSGASGHVRLAEGAITGLGIGVLGQRPRGRSTPPEASERIMDPAPRSRSRPASPEPDRQEGDNQSQSSRRSSILRSKDSPTAVPLHFRRPPASPGTNRSVSVGTPTAPSPGSPTTPKRRPNSTEFKNSREMRPLWLVERHGPGHGEHKLEEPLPSLPSSKTSSANTSVEDLTALQDERSWEAVDLSHHVHGMRRLSGIDVSQSRGFEHDAFGSQHVTPTATTFEQIHPHSRKEKLKYEFHSPSELLQDPSPYGDVQPSNMGDLPSAEGSAVGVKDASSENEDSAELAAEALPPRPSTPQNNVTAASEDTETTPTQTRTVNAFEGPGFAGVVDAAVAAAVSNRLSTRPDVAIPDKSSPEDLPYDADRTHKPIADQELAATSPPAPGVPLGFAAVVDAAVAAATISIGGQPEAAKELEQSPEISEPIPQTPHPNEQETSHPTGNDSVPRDDKRRDSVDTVVPQAEEASDEKEKLDTSAVMPDLTGENKELPSEAKNENANDNSQAQTEQPPVDTDEPSSSSAKKKKKKNKKKRQSMDSNTQEPTTPVDDSTIDQGGVGISAVEDAQADAVETFEPAPKEQILVEQPASAEPTPAPEPEPTETTVDVEKAIEAPDVRKELEEEPAPAAPEDTPAEPTAETPAEDQAETSSSKKSKKKKKKKNKGSAPEENTEDPASTETPEASAANSQVVAAEQVESTLETTQPAEEEPKPTEESAIAVAENTVEPEPAPKEMEATEDPMFQDISVPGESQDSPADADNQAKELPHPEEEFQAEATHAQELPEDTEIINKTDDLSSGIDPSGQAGGDMVNEAASPEVWHDALASSPEDKNGEAEQADLKSNEPQNEGKAPVSELPALDKELSEISERPAEVDAPADTPLVDSPSTDQVEAADSGVQNEEPTPTAAELETPLSRKNSKKNKKKNKRKNTAETPVQNEAVHTADPISSIEGVPEPGPEATTTAVEEPQVTLPDEAVDENKGESRDVQAVKEETSPENAAEVANDSQPSTFEEIHLAGAEQSAPDAIAEIMGESQPAEPQDVLATAPEEPIDGQPKKKAKKKKNRKTANVSESQPESEAEAKTEKLQSAELAENPQPHIRDEVAGDSQVPPESGASEAPAGIEDVTPISAAEAVEFDLPVEKDETNGGEPHVSELNKQLNNETVPGPETGSEPVPEAGEITQSGKKSKKNKKKKQSLSLAPDETPASDPSTPAGTADGNADLPAAPEDSLKTDQEPMPEEPTVSQPIVDLVTETLNLSMAEEAVPMTAAQKKTKKEKKKKRQSALLDEPTATESIEEANAKDVTSEGTQMPLEVPSEPQSSGPTLDAIEHAEAAAEHSQEQPNKDVTLHADHSPNSDGEFVLVPEHVPYGSNDEHKTQPGSMELDVTQVNTELEKEPSTQEGVLEANEATPAETPSAADQHVQEESSPTPAMEGGAAAEELVAVEPDVLEGSQDKITEDNDTPDDSLTAKEPQTELVNAETTQKTEQGDVVLDVEAGSEGLVRDDQPVAPSKKKDKKKKKKRQSLTIDDEQRSSTKEEPTAEFSSDHVPEPSAVDESATTPSASEEQQKPETDITETVTQTAAEPTPSSASEEPENIAEAPSNESTQEPAAEEAQTAKSKKKAKKDKKKRKSVSFEIGEPLTQQSEPGHPTATPGETVTPHEGPKPGDKPTSPKDSSEEFQSGEAVPESPQDSAGIVTQPEQPEPTAEATVVTEQHKQVTEPSLVSINEEQAVVEETVAPPVVDEASQLQEQKVSSETLWSETQRDVVKSFQDAESLEEEKGETAVSPSLENNEGTKPGAWVEQAEFEPQTPTDDGEQGVGPSKSKKNKKKKKRNTLESTEDVPVIPPGPSKIELLESTPVLETEETHDIVEPDTTVSENVHEEEKPEDEFGGFMSAKAKKKAKKKDKKRQSKILDSANDATNTAESAPDISEQAPLETASGEADGPDATFSQETSETISTEAKSSEPSPETALTPAEDDGKENQSHDTEPHGGNDKDLTWTDHMVSSQVEQQQGTPSDRPSEPAPETEPISTREAATSIDVEQLDNNADDASPAVNDRLERSGEEGTRVKKEIVSEEPEVQYEGLLEIPREEKAEISSQGEDTIQVKSDAEVEESVKATVEGTPEDSMSQEDAPISVLDGGDATTKDQFTSIEVNDPSQSKDILEPENEELPLPIPGKKKKAQQETKIDETSQDDSVDAVQEESPTSREMTDTGLPVAESQADPIAEPFHELPEPQKAVEIAVEDKSMQETLKFKQDVTPAEDVFQEPPALGRKKSKKDKKKDLLAQNTAVESRENKFKEKQLATEEPLITPSDARTTVLATPVFTQALETPTKTTVDAGERELHLSAVQSTVPVEDNINALETSGAQTLESFRTLEAPEQPLERNILLNDYAAKTPEELPAVEKSATYETATEPIIEEAALSHKNSKKKSKKAKKQAQEQQEKSTTPTPAEHGEESIVETTAAIPSTPGPAENSDDIPEANISEEQVAQLEHSEQLVLSDAARPQERLGQTPNMDNQTDDVQSTEQGKEGNVQAEPRQVESEDPIESQPGSTAAVARKLSKKDRRKAKKKSAKDAIEPSDEPELRNPTEPIGASCSTSNQAKIDQDQFLTVASDKQMVEEVPRPLEVEPAASEVYQGATDENDWPAIDWEKGKVEFKEQTPLSSPEAHAVPFEPAIAEFDETAIPEGLLRRQSLSREEQLAGGKDGSSQHTRADEIAAPQEGAVMIEPSAVAETEQSAGLQAKSVSSQGAPKTIQDDMQHPENRLARDQTKSETGVVPSKQSKIGSIFPDLERGSFRRPVPGQVLMPVKDRAEDETIDQNADDNSAIKVSEAPIPAGEPEESHLQSQQDEKGPEPTTTVSTLDLSLEEPTKMQDTSNTPVNLAVDIEVDPSYNVSVISDGLVNETKSIEIEWKTDGDKGTQEAETPLYAPLPVHEQKSSLVSQASPLDMDRDEPIPRNDSSCGLRRSPSIHGRHNHPPRTWSLEDTPITKAVTPPLFGGPVGATADMSSPPRTPLQPIAEQEPEVRVEQASGFRSMVSEHGTPRLEMKPEHVLPRPETPIRKFTDNALARQTWPVAENDIFKSSEDEDAALTVKKQRPGNKWPAEVLKTPDKGMPILRPSSVSSVKSVQSTHSVTGGQRSLRRTSRNTSGDLRAASQAQESHGTQPHATPQPPQPPPSDLNIEHIASSSSYDPVTDKGKRPIRAMTDVYEGWGESPSSPRSPSRPPSIRHRRSMQHLQELEARLDQLISENRLLIAAREAAEDKLRNASVARRKSDHTLNERSADLRDREAEVEKLKKSVEWLQKEVTRLTEENEGLITTNSNLTAAHAKEIESVRESSSRQLDDLRSRYEQLSMEVQNTVRHEIETALARKDNELRRLREELETARDKVSQLQQQIAASLHDNVLVFRDEDYFDAACQKLCGHVQQWVLRFSKHSDHRRCRKLAEIQDEKIADRFDNAILDGYDTDTYLADRVRRRDIFMSVVMTMVWEFVFTRYLFGMDREQRQKLKSLEKQLNEVGPRSAVHRWRAITLTLLSKRPAFARQRESDTEAVALEIFETLSRLLPPPSHVEVQLLESLRKVLRVAVNLSIEMRTQLAEYIMLPPLQPEYDTNGDLARQVYFNASLMNERSGETTSNEELESQQAVVRVVLFPLVVKKGNDTGEGEDEVVVCPAQVLVARPDKDPRASKIFSSDRMSLDGTKSVHSVAPSSTMDISNVI