wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor expression-enhancing protein 4 (Q9H6H4)
Organism: Homo sapiens (Human)
Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23911198}; Multi-pass membrane protein {ECO:0000269|PubMed:23911198}.
Interaction partners:
- Receptor expression-enhancing protein 2
- Atlastin-3
- Receptor expression-enhancing protein 1
Sequence:
MVSWMICRLVVLVFGMLCPAYASYKAVKTKNIREYVRWMMYWIVFALFMAAEIVTDIFISWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDAYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSISDAPAPAYHDPLYLEDQVSHRRPPIGYRAGGLQDSDTEDECWSDTEAVPRAPARPREKPLIRSQSLRVVKRKPPVREGTSRSLKVRTRKKTVPSDVDS
Protein: Dipeptidase B, isoform A (EC 3.4.-.-, EC 3.4.13.-) (Dipeptidase B, isoform B) (Dipeptidase B, isoform C) (Dipeptidase B, isoform D) (LD41062p) (Q9VFQ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cytosol aminopeptidase
- Cytosol aminopeptidase
- Gamma-glutamyl transpeptidase, isoform A
- RE13973p
- Uncharacterized protein, isoform C
- GCS light chain
- glutathione-specific gamma-glutamylcyclotransferase
- glutathione-specific gamma-glutamylcyclotransferase
- Glutamate--cysteine ligase
- Aspartate aminotransferase
Sequence:
MGIEKILPCTLRLNKLMSLAGNDCLCIIDRNAVPNELKATFEEHRKFDKSFDSSISCFKVPNVDQPVVYAPVSELTDYDDVRSYQEAAKRSMEKVLKAGFHTPLLFVPKVKRFPEVELCTVLGALEQLYVPIQLREAGTLKDPRVTTLSVQIDDPRAEAIFQEALILEAGRFVARDIGVGDPERMTPIQVEKYIKPLFDKLNVNVISDTQVLQKEYPLFAAVNRAADAVERHRGRIIFLEYKPPKPARKTLMLVGKGVTYDTGGADIKAGGVMAGMSRDKCGAAAVAGFMQVVSQLQPDDIHVVAALCMVRNSVGEECYVADEVITSRAGLHVRIGNTDAEGRMCMTDALCRMKELVVEQNLPDPHLFTIATLTGHAFISAGEGQSIAIDNSVAHREDHARRLQAAGQAFGEPFEVSILRPSDFSFNAGKVIGEDLVQANNAPSVRTPRGHQVPAAFMIKASGLDKHGLDSMLPIKYTHIDIAGSAGEHPAMPTAAPLVSLVKTHLQK
Protein: Protein Wnt (B6V3E1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Frizzled class receptor 9b
- Protein wntless homolog
- Secreted frizzled-related protein 3
- Axin-2
- Catenin beta-1
Sequence:
MLDGHLLLGWLSFTIIVHLISLPGPSTAYFGLTGNEPLSILPLTSQPDERAGKSHYKLCDRLKLEKKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRANILKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCTCDEAPDLENRKAWQWGGCGDNLKYSNKFVKDFLGKRSNKDLRARIDMHNSNVGMKVIKTGVETTCKCHGVSGSCTVQTCWRQLAPFHEIGKQLKQRYETSVKVASSTNEATGEGEISQSRSQSQQPPQPDIPRTPDLLHIEDSPSFCRPSKYSAGTLARKCYKDKNCEAICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQKEEVYTCKG
Protein: Uncharacterized protein AN4029 (Q5B601)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Involved in osmoadaptation.
Interaction partners:
Sequence:
MPHLPELSKQEPSANTLVDNYRAKGEDLENSHHNNESRLAEGVHYDRNKAPALQEREKASTEKVNVEGGGASSSMVDNIRRGNPSGVA
Protein: Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) (Q6ZN44)
Organism: Homo sapiens (Human)
Function: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O08721}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08721}. Membrane raft {ECO:0000250|UniProtKB:O08721}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O08721}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. {ECO:0000250|UniProtKB:O08721}.
Interaction partners:
- Netrin-1
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
- Melanoma-associated antigen D1
- Netrin receptor DCC
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Netrin-4
- Tyrosine-protein phosphatase non-receptor type 11
Sequence:
MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC
Protein: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (F5GWN5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGTL
Protein: Transcription regulator complex subunit bur6 (Q10315)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcription regulator complex subunit that is essential for cell cycle progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:15388803}.
Interaction partners:
- Negative cofactor 2 complex subunit beta
- TATA-box-binding protein
- TATA-binding protein-associated factor mot1
- Diphosphomevalonate decarboxylase
- DNA polymerase epsilon subunit D
Sequence:
MGDPTNNNDSETKPNPATYWKSRFPVARIKKIMQADQDVGKVAQVTPVIMSKALELFMQSIIQESCKQTRLHQAKRVTVSHLKHAVQSVEQFDFLQDIVEKVPDAPPIKAERKTKRPRARRAANEGEHNESVPAKKVKKNTVKEEEIEKDDESATTETPVKEEPTGEETEADHEEKASVDHGNFSDKTTSEASSASGDE
Protein: Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) (P80109)
Organism: Bos taurus (Bovine)
Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:9042330}. Note=Associated with the High-Density Lipoproteins (HDL).
Interaction partners:
- Glucosaminyl-phosphatidylinositol-acyltransferase PIGW
- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- Apolipoprotein A-II
- Apolipoprotein C-III
- Apolipoprotein A-I
- Apolipoprotein B
- Platelet-activating factor acetylhydrolase
Sequence:
MSAFRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYRELYGRIVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPAASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPRIDLDLDKEAHGILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSREKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGLDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD
Protein: RING finger protein vilya (O76908)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the formation of DNA double-strand breaks during meiosis together with narya and nenya.
Subcellular location: Chromosome {ECO:0000269|PubMed:26452093, ECO:0000269|PubMed:30615609}. Note=During early pachytene, colocalizes with narya to the central region of the synaptonemal complex (SC) in both linear stretches and discrete foci which correspond to recombination nodules. As pachytene progresses, found mainly at recombination nodules. Double-strand break formation is required for recruitment to recombination nodules but not for linear localization to the central region of the SC. {ECO:0000269|PubMed:26452093, ECO:0000269|PubMed:30615609}.
Interaction partners:
- RING finger protein nenya
- RING finger protein narya
- Meiotic recombination protein P22
- FI18611p1
- Meiotic recombination protein W68
- Crossover suppressor on 3 of Gowen
Sequence:
MAKSQAGQTVEPEASKLWIHCNSCCALFCDKKHTFFLLACHHVFCERCVKVSAGRTPSDAPIFECSTCRRSVRGRQLTNSMPNHFKQLFHPEPFTIGNDFVETFQRGNHRHFDKYKERKELEMDKLFKDIEVAKSVCQKRFLEAQMLRVERKKLMQRSRYIKAEVANRKAEMHRMAQAYRSRSLTSQSSSSAQRSARGRPRGRGTATQSSSRRRSTESAKRQQITSFIHPPNNSFDL
Protein: SEC14 domain and spectrin repeat-containing protein 1 (Protein Solo) (Q7SX85)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels trpc4 and trpc5. Binds phospholipids (By similarity).
Interaction partners:
- Si:dkey-237i9.1.
- SEC14-like lipid-binding 1.
- SEC14-like lipid binding 1.
- Transient receptor potential cation channel, subfamily C, member 5a
- Short transient receptor potential channel 4b isoform X1
- Enkurin
Sequence:
MEASCILPVLKKKLAFLSGGKDRRSGLILTIPLCTEQTSMEELSTTLDYLLGIPSEKCKARGFTVIVDGRKSQWNIVKTVVLMLQNVIPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTDEFGGSLLYDHLDWVNKRLVFEKFTKESTSLLDELIVINENEKGSQAEKDRSSESNILPSFDPETVLQTGHELLSELQQRRFNGSEGGGGGGTAWSPMDDELLAQPQVMKLLDSLREQYTKYQEVCRQRSKRSQLEEIQTKVMQVVNWLEGPGTDQLRTQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLSAGDEEDLMELKGLQQQLSDVCYRQASQLEFRQNVLQSAYEFHMTAQDLSQQLDGLLGMLCADVAPADGAAIQQTLKHLEEKLKSVESALQTLREKGQALLDQMSNQTSFSYGKEVGVENKENIDHIHSVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLGELLDALLKTHIRLGDDSQETKVLLEKHKKFVDVAQSTYDYGRQLLQATVVLCQSLRCTTRSSGDTLPRLNRVWKQFTVTSDERQHRLEMASAFHTAAEKIVRESPELAELLVDVEAYEEVETLGKGLLDRLTVPVIFPDGSEQFFGSPGDMASSAESIRERMKLVEEKRFLQEEAEQRLEEEEEEEEAALEVEPRES
Protein: Mesoderm-expressed 2, isoform C (SD15211p) (Q8IG95)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHDNPILWDSRLPNFKGAEEEKNRAWEHIGREFNAPGRRVARAFKSLRESYRRELAHVKLMGNGFKPKWSLYEAMDFLRDVIRERKGASHATDLSLTTYGHINNNNNNNNNSNSLAAGGKAMTLKLSNSFNESASVLNLSKCSSLNVSDDHYYCDYYVKPELDLSVGGGAGSSTSGSSSGGGPLPLPAHQAHNDSRVSSTRNEQRAQHHSYEDMDDSSIRSGDEDIAHASDVVEELDAIDADFPYPLILDSNSRGSPNVGVDDVVMSRKLRRNVDQDVLEEGNGHGDAVIDGDDYEEQMLQQHRHLRQQQGVASGGLDLPPPQTVREVLNSKFCGFISAKLNSMEDSDADNLMNRILLLLVQVQQCEGSTK
Protein: Noelin-3 (Olfactomedin-3) (Optimedin) (P63057)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000269|PubMed:22632720}. Synapse {ECO:0000305|PubMed:22632720}. Note=Isoform 2 is secreted more efficiently than isoform 1.
Interaction partners:
- Glutamate receptor 1
- Myocilin
- Glutamate receptor 4
- Protein cornichon homolog 2
- Voltage-dependent calcium channel gamma-2 subunit
- Leucine-rich repeat transmembrane neuronal protein 4
- Glutamate receptor 2
- Voltage-dependent calcium channel gamma-8 subunit
- Glutamate receptor 3
- Neuritin
Sequence:
MSAPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSAPDTLTQISPKEGWQVYSSAQDPDGRCICTVVAPEQNLCSRDAKSRQLRQLLEKVQNMSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQIEDDRKTLMTKHFQELKEKMDELLPLIPVLEQYKTDAKLITQFKEEIRNLSSVLTGIQEEIGAYDYEELHQRVLSLETRLRDCMKKLTCGKLMKITGPITVKTSGTRFGAWMTDPLASEKNNRVWYMDSYTNNKIVREYKSIADFVSGAESRTYNLPFKWAGTNHVVYNGSLYFNKYQSNIIIKYSFDLGRVLAQRSLEYAGFHNVYPYTWGGFSDIDLMADEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKRSAGESFMICGTLYVTNSHLTGAKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDRALYAWNNGHQVLFNVTLFHIIKTEDDT
Protein: Beta-1,3-galactosyltransferase 2 (Beta-1,3-GalTase 2) (Beta3Gal-T2) (Beta3GalT2) (EC 2.4.1.86) (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II) (O54905)
Organism: Mus musculus (Mouse)
Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 4
- CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
- Galactoside alpha-
- Galactoside alpha-
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- Beta-1,3-galactosyltransferase 5
Sequence:
MLQWRRRHCCFAKMTWSPKRSLLRTPLTGVLSLVFLFAMFLFFNHHDWLPGRPGFKENPVTYTFRGFRSTKSETNHSSLRTIWKEVAPQTLRPHTASNSSNTELSPQGVTGLQNTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNETLAPGIQIIRVFLLGISIKLNGYLQHAIQEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVATYCPHTPYVMKTDSDMFVNTEYLIHKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRVDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRKLH
Protein: Protein disulfide-isomerase MPD1 (EC 5.3.4.1) (Q12404)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Participates in the folding of proteins containing disulfide bonds.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Endoplasmic oxidoreductin-1
- Protein disulfide isomerase MPD2
- ER-retained PMA1-suppressing protein 1
- Tryptophan synthase
- Endoplasmic reticulum chaperone BiP
- Protein disulfide-isomerase
- Nucleotide exchange factor SIL1
Sequence:
MLFLNIIKLLLGLFIMNEVKAQNFYDSDPHISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAAKRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEVYSGARTLAPIVDFSLSRIRSYVKKFVRIDTLGSLLRKSPKLSVVLFSKQDKISPVYKSIALDWLGKFDFYSISNKKLKQLTDMNPTYEKTPEIFKYLQKVIPEQRQSDKSKLVVFDADKDKFWEYEGNSINKNDISKFLRDTFSITPNEGPFSRRSEYIAYLKTGKKPIKKNHSSSGNKHDEL
Protein: Uncharacterized protein (Q5B4P6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
Sequence:
MPSIEVVSSPASSEHPDRLLLKSHKSLPRRTNTNPHGQFSQSSPTEHDGHFSGGLPPMAVPILPLTPPGITQNENPTGASAQKSTLSSHSVTNVLTPSRLSHPPTPETTPPRVMASNRPGLSQFGYISSSSRAESFKTAHETMSDAETVTPRASPPLLSRSDTQKSTKSTKSSRANRTDAITKDLAARELFRESPRSKVEKHVEKKPLATADISRKQNLANGQASELCVKPTRDKSKGTRNAADSTVTDIDASARGRRSLRDRVAHVQHPDDSPALDQFRQEIGWPSADDELARLEDHRRLSGVSASSTIEAVIVDKPRPARRALRHTEKRSSLRSASSPITASERTSITSSSDLGRRLSHKPNRITENDRRSVSSELSVSVSSTLGVPQQSVDVVPVVVIPQRHSSLKGPSNSSSKNPSISRSRPSIHAPAVPGSRVGSQDLPRGKRTVSESRVSDDDRGRGLSRPHVPPRSSSLSAPTSQNNSRATSLTSESLRSHNLALEQVKKQHQPEKVQPPSIPVDSPSLDQHDASDILKTQSIVIGVEDMSYLRPPSVPFTPHSVPSSSPGPFEISEVRRVAIFPHNNESLLLVNPHGQSNLRAQLQQAEQPQTPDNTQQTTDVDSPLRNPRPPPKPPVSAAADNFVDFDQLPGEVTNGKDPTNGIDRRPSSKRRPWIARPRSESFNSFVRTLSLNSARNPKAGEDIDGRSQPFWRPRRFWDDSPDSLSPEEGNSRPRNLKQPDEIISNSLGMPQKRVVFDGPPVSAARPGAVRRTDGHRANRTMLIGSGIFSPEALYSQTSLHQRRFPAVPRWRLRFRSGIARSLRWRLRRSIQQRVEGRREVRREKLKQSIGEAVLMDSSTQVRKSHTMK
Protein: Apical meristem formation protein-related (NAC (No Apical Meristem) domain transcriptional regulator superfamily protein) (T13D8.25 protein) (O80759)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F11O4.3
- DNA replication ATP-dependent helicase/nuclease JHS1
Sequence:
MADTLLNAEDEVIISRYLKPMIVNRVSWPDLFIEDADVFNKDPYVKFHAEIPSFVIVKPRTKACGKTDGCDSGCWRIIGRDKLIKSEETGKILGFKKILKFCLKWKPREYKRSLVMEEYRLTNNFNWKQDHVICKIRLLFEAEISFLLAKHFYTTSDSLPRNVLLPAYGFCSPDKQEEDEFYPVTIMISEGKDWPSYVTNNVYCLHPSELVNVHDGKFHDNGICIFANRTCGVTDKCNEGYWKIKHREKLIMSRYGQTIGWKKVFQFYETEKERHFGNGEEVKVTWTLKEYRLTRKMNKNKVVCVIKYKVKCLPRITS
Protein: Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) (Q15306)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor PU.1
- Basic leucine zipper transcriptional factor ATF-like
- Myeloid differentiation primary response protein MyD88
- Signal transducer and activator of transcription 6
- Signal transducer and activator of transcription 3
- Paired box protein Pax-5
- B-cell lymphoma 6 protein
- PR domain zinc finger protein 1
- Transcription factor Spi-B
- TNF receptor-associated factor 6
Sequence:
MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHISNPEDYHRSIRHSSIQE
Protein: 60S ribosomal protein L6 (Q8N5Z7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGEKVEKPDTKEKKPEVKKVDAGGKVKKGNLKAKKPKKGKPHCGRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF
Protein: Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) (P51855)
Organism: Mus musculus (Mouse)
Function: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.
Interaction partners:
- Glutamate--cysteine ligase catalytic subunit
- Glutamate--cysteine ligase regulatory subunit
- Glutathione reductase, mitochondrial
- Glutathione hydrolase 6
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Glutathione peroxidase 1
- Glutathione peroxidase 3
- Glutathione peroxidase 2
- Glutathione hydrolase 7
- Glutathione hydrolase 5 proenzyme
Sequence:
MATSWGSILQDEKQLEELAKQAIDRALAEGVLLRSAQHPSSSDVVTYAPFTLFPSPVPSALLEQAYAVQMDFNILVDAVSQNPAFLEQTLSSTIKKDDYTARLFDIYKQVLKEGIAQTVFLGLNRSDYMFQCGADGSKALKQIEINTISASFGGLASRTPAVHRHVLNVLNKTKEASKILSNNPSKGLALGIAKAWELYGSANAVVLLIAQEKERNIFDQRAVENELLDRKIHVIRGRFEDVSERGSLDQNRRLFMDDQEVAVVYFRDGYMPSQYNSQNWEARLMLERSRAAKCPDIAIQLAGTKKVQQELSRVGLLEALLPGQPEAVARLRATFAGLYSLDMGEEGDQAIAEALAAPSHFVLKPQREGGGNNLYGEEMVQALEQLKDSEERASYILMEKIEPEPFRNCLLRPGSPAQVVQCISELGIFGVYVRQGTTLVMNKHVGHLLRTKAVEHADGGVAAGVAVLDNPYPV
Protein: PTP1-interacting protein, 39 kDa (Q38BR1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPRLLLPCGVELINSSTSQPHNMLVNEEQRGLEERSVLNAEMDFFTDEYLSAHAGATRPHTTISGNTRETCNGEQGSCVSQERTTEGSIAAIDCDVSLQLIQSGRGSGHSVVYTVRVPAAVSFSSPSTESELAANGSATSLRLQQIVNSEWRNRKEEMTNMGGAWEGRESTPTAATCCCDAFDCEEAAAGPNYPADRFRGRRLATPKATPYGTGADPSATHFEETFRNTAFSISETGINPVSHLPPVCAVRLPPDFVFGLRLPPDTERRLVELYNGGSVTLREVKTPKIPKWLTAFFYTSGVRCQLSTPLPSTPETRLVGGLMNKLSAVSVLEGFCIAALHVVSHMGELRLHNGGQKLHVSETAGVDDAQRCLLDEGGIFAHTQEEQIRLWLHRYVPQEAYTNGRDGDVAQRDADSTSVYPSAVAVVYYIAIELARGLFPCILSGLEATILTALQPLVSAQTLIPEVSGCRSSRLPRPASHNRAISLLTQSPMSLWWWWRQRDSHSDAVERECNGKNKALSSLPIRCPNAVATARGYGAVRFLKFFSFFCVEQITAETRHVEEAREFFEVAQFLASSSALFSELLLDREVMSVLERTTTEVGKLTRKEAEDCGHGRANAEPTQVTRILMRCFVVLICWMAFRPSGYSRSLARTYFAYILRPASCLCELSMKRGMISDAAKKDGVNSALVACVHDYFSKISSLLHAVRGFSRPQRRRRQQADFPSRNPWRPLGCTEEVSVLGNGDCGCNDDQTTITSRSHASASSFLPTHSSNGIATNPAHHLLTRGLSCATSEDELIFSSHSLRLLRHAIRHARGVLQSLRSDVLGTSECTAAFDVVTGSKRFRESSGTSTLEGAYDQCAPQCEMKCACAKTPQLHHFLGECEDPSLYVGGVLWSVSSEDEEDSAGIFTTSTTTNPTTPTTASDSGTGSAIEATSWHFVE
Protein: Epsilon-sarcoglycan (Epsilon-SG) (O43556)
Organism: Homo sapiens (Human)
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Interaction partners:
- Delta-sarcoglycan
- Beta-sarcoglycan
- Sarcospan
- Dystroglycan 1
- Dystrophin
- Retrotransposon-derived protein PEG10
- Torsin-1A
- Zeta-sarcoglycan
- Caveolin-3
- Gamma-sarcoglycan
Sequence:
MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP
Protein: Metallothionein-like protein 1B (Class I metallothionein-like protein 1B) (OsMT-I-1b) (Q10N03)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of nickel (Ni), cadmium (Cd), zinc (Zn) and copper (Cu). Possesses higher affinity for Ni and Cd ions compared to Zn and Cu ions.
Interaction partners:
Sequence:
MSCSCGSSCGCGSNCTCGKMYPDLEEKSSSAQATVVLGVAPEKAHFEAAAESGETAHGCGCGSSCKCNPCNC