wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (RIG protein) (RP52) (S21) (YS21) (Q01855)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uS19 is involved in the nuclear export of the small ribosomal subunit precursor. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS21A
- Small ribosomal subunit protein eS4A
- Large ribosomal subunit protein uL6A
- Small ribosomal subunit protein eS1A
- Small ribosomal subunit protein uS14B
- Small ribosomal subunit protein eS27A
- Small ribosomal subunit protein eS10A
- Small ribosomal subunit protein eS7B
- Small ribosomal subunit protein uS11B
- Large ribosomal subunit protein eL19A
Sequence:
MSQAVNAKKRVFKTHSYRGVDLEKLLEMSTEDFVKLAPARVRRRFARGMTSKPAGFMKKLRAAKLAAPENEKPAPVRTHMRNMIIVPEMIGSVVGIYNGKAFNQVEIRPEMLGHYLGEFSITYTPVRHGRAGATTSRFIPLK
Protein: Myogenin (Myogenic factor) (P17920)
Organism: Gallus gallus (Chicken)
Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- PAX7 protein
- Paired box 3
- Myocyte enhancer factor 2D
- Myosin-1B
- Growth/differentiation factor 8
- Transcription factor 12
- Myosin-1B
- Acetylcholine receptor subunit delta
- Uncharacterized protein.
- Myocyte enhancer factor 2B
Sequence:
MELFETNPYFFPEQRFYDGENFLGSRLQGYEAAAFPERPEVTLCPESRGALEEKDSTLPEHCPGQCLPWACKICKRKTVSIDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQSLLSSLNQQEREQRELRYRPAAPQPAAPSECGSGSSSCSPEWSTQLEFGTNPADHLLSDDQAEDRNLHSLSSIVESIAVEDVAVTFPEERVQN
Protein: ADAM metallopeptidase with thrombospondin type 1 motif 6 (D3Z1A5)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MEISWKTLTWILSLIMASSEFYSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDLLDPQQAVSKLFFKLSAYGKHFHLNLTLNTNFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQHSTTKVALSNCVGLHGIIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSTLQQQHIYDHSHCGVSDLTGSGKPWWLNKTSSFPSLPPINDTHIHHRKRRSVSTERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDSMPFRGKHYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTIDWPRKFDVSGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPIVRTGSGDNEVGFMWTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEETLDYGDCLTHRPVEKESCNNQSCPPQWVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASVDCPETVRPPSMQQCDSKCDSTPLSSTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
Protein: Peroxiredoxin TSA1 (Prx) (EC 1.11.1.24) (Cytoplasmic thiol peroxidase 1) (cTPx 1) (Protector protein) (PRP) (Thiol-specific antioxidant protein 1) (Thioredoxin peroxidase type Ia) (TPx type Ia) (Thioredoxin-dependent peroxide reductase) (Thioredoxin-dependent peroxiredoxin TSA1) (P34760)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Protects the cell against the oxidative stress caused by nascent-protein misfolding and aggregation. Relays hydrogen peroxide as a signal to the transcription factor YAP1 by inducing the formation of intramolecular disulfide bonds in YAP1, which causes its nuclear accumulation and activation. Can act alternatively as peroxidase and molecular chaperone. Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch. The chaperone function of the protein enhances resistance to heat shock.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10681558, ECO:0000269|PubMed:18271751, ECO:0000269|PubMed:24424024, ECO:0000269|PubMed:8344960}. Note=Associates with ribosomes (PubMed:18271751). Colocalizes with sites of protein aggregation adjacent to active mitochondria (PubMed:24424024). {ECO:0000269|PubMed:18271751, ECO:0000269|PubMed:24424024}.
Interaction partners:
- Sulfiredoxin
- Thioredoxin-2
- Peroxiredoxin AHP1
- Thioredoxin reductase 1
- Thioredoxin-1
- Peroxiredoxin TSA2
- Glutathione peroxidase-like peroxiredoxin HYR1
- AP-1-like transcription factor YAP1
- Superoxide dismutase
- Glutathione peroxidase-like peroxiredoxin 2
Sequence:
MVAQVQKQAPTFKKTAVVDGVFDEVSLDKYKGKYVVLAFIPLAFTFVCPTEIIAFSEAAKKFEEQGAQVLFASTDSEYSLLAWTNIPRKEGGLGPINIPLLADTNHSLSRDYGVLIEEEGVALRGLFIIDPKGVIRHITINDLPVGRNVDEALRLVEAFQWTDKNGTVLPCNWTPGAATIKPTVEDSKEYFEAANK
Protein: Troponin C, slow skeletal and cardiac muscles (Q800V7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Troponin T type 2a
- Novel slow skeletal troponin T family protein
- Troponin T2d, cardiac.
- Slow troponin T
- Troponin T type 2b
- Troponin C, slow skeletal and cardiac muscles
- Fast skeletal muscle troponin T
- Troponin I type 1a
- Troponin I type 1b
- Troponin T type 1
Sequence:
MNDIYKAAAEQLTDEQKNEFRAAFDIFVQDAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFEEFLVMMVRCMKDDSKGRPEEELAELFRMFDKNADGYIDLDELKLMLEATGEAITEDDIEELMRDGDKNNDGKIDYDEFLEFMKGVE
Protein: Lithostathine-1-beta (Pancreatic stone protein 2) (PSP-2) (Regenerating islet-derived protein 1-beta) (REG-1-beta) (Regenerating protein I beta) (P48304)
Organism: Homo sapiens (Human)
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
Subcellular location: Secreted.
Interaction partners:
- Lithostathine-1-alpha
- Endoribonuclease ZC3H12A
- Regenerating islet-derived protein 3-alpha
- Defensin-6
- Defensin alpha 5
- C-type lectin domain family 1 member A
Sequence:
MAQTNSFFMLISSLMFLSLSQGQESQTELPNPRISCPEGTNAYRSYCYYFNEDPETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESSTDDSNVWIGLHDPKKNRRWHWSSGSLVSYKSWDTGSPSSANAGYCASLTSCSGFKKWKDESCEKKFSFVCKFKN
Protein: 6,7-dimethyl-8-ribityllumazine synthase, chloroplastic (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) (O80575)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic
- Monofunctional riboflavin biosynthesis protein RIBA 3
- Monofunctional riboflavin biosynthesis protein RIBA 2
- Riboflavin synthase
- Bifunctional riboflavin kinase/FMN phosphatase
- FAD synthetase 1, chloroplastic
- Flavin mononucleotide hydrolase 1, chloroplatic
- Riboflavin biosynthesis protein PYRD
- 5-amino-6-
- Methyltransferase family protein
Sequence:
MKSLASPPCLRLIPTAHRQLNSRQSSSACYIHGGSSVNKSNNLSFSSSTSGFASPLAVEKELRSSFVQTAAVRHVTGSLIRGEGLRFAIVVARFNEVVTKLLLEGAIETFKKYSVREEDIEVIWVPGSFEIGVVAQNLGKSGKFHAVLCIGAVIRGDTTHYDAVANSAASGVLSASINSGVPCIFGVLTCEDMDQALNRSGGKAGNKGAETALTALEMASLFEHHLK
Protein: Protein DMP7 (AtDMP7) (Q5XV67)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in membrane remodeling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20712629}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Membrane-anchored ubiquitin-fold protein 2
- DNA polymerase I A, chloroplastic/mitochondrial
Sequence:
MEETKQSLIASLPSAPRKPKSKVERVVRKTFKGTAHLSNLLPTGSVMSFQIMCPVLTHQGQCPTITSRWLTCFLVSLCAISCFLFSFTDSIRDPNGKVRYGLATWSGLLVMDGSITLTEEEKEKYKLKILDFIHAIMSMLVFFAVSMFDQNVTRCLFPVPSEETKEILTSLPFVIGVICGAFFLAFPTRRHGIGSPLTKE
Protein: At1g64330 (Myosin heavy chain-like protein) (Q9C7V7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Filament-like protein
- Haloacid dehalogenase-like hydrolase
- Transmembrane protein, putative
- C2 domain-containing protein At1g53590
- Protein NETWORKED 2D
- At3g45160
- F3M18.16
- Heavy metal-associated isoprenylated plant protein 25
- Protein PELPK1
- Structural maintenance of chromosomes protein 2-2
Sequence:
MRKLSIRDSLKSFFEPHLHPDNGESLKGTKTEIDEKVKKILGIVESGDIEEDESKRLVVAELVKDFYKEYESLYHQYDDLTGEIRKKVHGKGENDSSSSSSSDSDSDKKSKRNGRGENEIELLKKQMEDANLEIADLKMKLATTDEHKEAVESEHQEILKKLKESDEICGNLRVETEKLTSENKELNEKLEVAGETESDLNQKLEDVKKERDGLEAELASKAKDHESTLEEVNRLQGQKNETEAELEREKQEKPALLNQINDVQKALLEQEAAYNTLSQEHKQINGLFEEREATIKKLTDDYKQAREMLEEYMSKMEETERRMQETGKDVASRESAIVDLEETVESLRNEVERKGDEIESLMEKMSNIEVKLRLSNQKLRVTEQVLTEKEGELKRIEAKHLEEQALLEEKIATTHETYRGLIKEISERVDSTILNRFQSLSEKLEEKHKSYEKTVVEATKMLLTAKKCVVEMKKEKDEMAKEKEEVEKKLEGQVREEEKEKEKLKETLLGLGEEKREAIRQLCIWIEHHRDRCEYLEEVLSKMVVARGQRRSQRA
Protein: Glycine amidinotransferase (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (A0A140VK19)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367092}.
Interaction partners:
Sequence:
MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHLKKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYLD
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (Q66I04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGCKKSKLDGDQNGCVLEPVNKEHPVRTDQTYVRDPTSYKPPITSQNAGLLPGQVFQKMEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKARSLTTRKEGFIPSNYVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSVEAFLEEANLMKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVELYEIMTTCWKNKPEDRPTFDYIQSVLDDFYTATEGQYQQQP
Protein: Lysine-specific demethylase 7A (DrKDM7a) (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 1D-A) (Q5RHD1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Lysine
- Lysine-specific demethylase 5D
- Lysine-specific demethylase 8
- Lysine
- Lysine-specific demethylase 4B demethylase 4B)
Sequence:
MAAAPLYCVCRQPYDVNRFMIECDICKDWFHGSCVQVVEHHAADIDVYHCPNCEPIHGPYMMKKHNNWHRHDYTEPNDGTRPVQAGTAVFVKELQARSFASGDILVQMQGNQVTKRFLEKEGFNYPIVVHDLDGLGLKLPPPSFSVSDVEHYVGANKVIDVIDVAKQADSKMKLGEFVKYYYQPERPKVLNVISLEFSDTRMSNLVVVPDIAQKMSWVENYWPDDSFFPKPFVQKYCLMGMKNSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTKANLALYEAWSSSPNQSEVFFGEKVDKCYKCVVKQGTTILLPTGWIHAVLTSQDSMAFGGNFLHNLNIDMQLRCYEMERRLKTPDLFKFPYFEAICWYVAKNLLETLKELRENKCEAQGFLVNGVKALISSLKMWLRRELTQPNSEVPDNIRPGHLIKALSKEIRHLEDDSNKAVKTQGSAECSLSRSTLEKGDQAQQAARRLQDHHHHRRRHHHHHHHHHHHHHHHHSRKLPSNLDVLELHTLEVLKRLEVGQLKEDSAFSSKVNGKFKKVCPVPAAAVEASHDNALRLVMCNGKIIRERMPITNVAATVNAVEMYHKHRIKLERIPMCPEEKVKKEKCEDEFGVQCTIKKPVSQGESVQTELRTESPHLASSDSDSKAGDSAEKCSLESESSDGEDGGSQRDSGTFVEHLNSHRHSHHKQALKRERPTSPNTDCAIQGMLSMAGLLCPQASGGAADILQQRWWASQGNGSSTSSSSDMWDSSEPCSAPRSPDAEDGSLGEEYSYRESSLSPPLHPSKRHAPNPTPVSNQATKGKRPKKGQATAKQRLGKILKMSRHKGLFLMKPMVFLIPQQGGTPLDPQFLLQSSSICVFPPPLIVSG
Protein: Uncharacterized aminotransferase C1039.07c (EC 2.6.-.-) (Q9US34)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Biotin synthase
- Protein arg11
Sequence:
MSSHVSNNSILDPVTFWNQANKSLIRYGGDFAPKIIVRAKGCCVYDEQDNAILDFTSGQMSAILGHSHPDITACIEKNLPKLVHLFSGFLSPPVVQLATELSDLLPDGLDKTLFLSTGGEANEAALRMAKVYTNKYECVAFSSSWHGVTGGAASLTFAAARRGYGPALPGSYTIPEPNPKLSPFRDAKGNYDWQKELDYSFYMLDKQSTGSLACMIVETILSTGGIIELPQGYLKALKKKCEERGMLLIIDEAQTGIGRTGSMFSFEHHGIVPDILTLSKSLGAGTALAAVITSEEIEKVCYDNGFVFYTTHASDPLPAAIGSTVLKVVKRDNLVEKAKISGELLRSDLLRLKDKHPLIVDVRGLGLLQGIEIASCTDPSKPSDFLGTVIGDKCLELGMNCNIVHLRGIGGVFRIAPPLTVTDEEIHKAIEIFDSALTFTAKEFSGSY
Protein: Cholesterol uptake protein 1 (Q9GYF0)
Organism: Caenorhabditis elegans
Function: Cholesterol-binding protein which is involved in dietary cholesterol uptake from the environment. Does not play a role in double-stranded RNA transport in contrast to other SID1 family members.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22479487}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sphingomyelin synthase-related 2
- IntraMembrane Protease
- Transmembrane 9 superfamily member
- Transmembrane 9 superfamily member
Sequence:
MRTSQAIFILIFLDSVRNQSPQVIPAKWDVVYEKETGHNMSLTVFRFQVKEQYSVARIIMSCNESTEHNPLLAVFREKLAILSLQVPLIVDNYEYSQVARTLCPFTEYKEGEAFTVEVTSSRPVHYNFRAELVQNFYLYNNSQRLVTASASEPVYLRYDIPGDVDSVAVHLDSNSTICMTVSVQKIGCPVFDLPDNVNSMGLHQTMTTSATIPVEKSRMSSFYVVFVVNTNDDLCSEILSIKPNKPTKFPLRMKSFNVTIESSMKIFDYTIPIVFWACILLLVTIVVFVYHYFDGIWERRFVSRAYTHLEDNAQEQRIRDFYDFQRMSEDDDLKDYDLLTDCQDMMVVRAKASLTVADLSMTPYEERELKYDVYKIALAIIGIFYNITVLQLIISKAGSLRQSGDLDECTFNFQCARPLWYFVAFNNVVSNGGYVYFGTLIIVMNYCRERSFRRLFAVQPTLAERYGLPQHSGLMTAIGLAVIMEGISSATYHVCPNNINYQFDTALMYVIGMLGKLKIWSLRHPDMVVSAYHAFGFLGVFLMAAIAGVYVHNMIFWALFSIIYIASMLLVSLEFYFKGIWTLNLRELRNSIRLSWVSSRHLSCVVPAYKARFFVILLLNIANTAVVVYGLEAHPKDFLSFLLIPFIGNLFIYIIYYILMKMIYREKIPKRAIALLFAAVISWTCAGILFNQRVSDWSKMPAISRELNKPCIFLNFYDNHDLWHLSSAFAIFFSFTAINVIDDDLMFVMRNTIRVF
Protein: Double-stranded RNA activated protein kinase (IFN-stimulated dsRNA-activated eIF2-alpha kinase 2) (Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.1.-)) (A9YT50)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MESLSGNYTSLLNEYQQKTQCTVEFEEGPTDGPSHNKRFTMRAIVNGQKFPDGTGKTKKEAKQNAAKNALEGLKSTHSDEPTPSPVENISVSKIASHPNYTCWLNEHSQKSRLMFKACESTKMDPGNLTRLCTYVCKYVCDDKEFPEGYGKNKKEAKEAAALRVYEELNKTPNTEVLDENSNRAQRSETTSYSLDRRSSVADDSRSSTPDNNYIAYLNNYCQKKKRVYDFKLVDRIGPPHNPIFVYKVVMDGKEYPEAQGRNAKEAKQNAAQHAWSEIRDQSGWTTPSSEDGAFSQSQDTCKSEDVQRSANASSTSNFISFRDSAAAASSPMATSPSVSLVDVKPKIKLAPRFLLPNGLDRSKEGGPDMKVPNPAKASGGQTPNSATKSRFLEDFDSINPIGKGGFGRVFKARRKLEDKYYAVKIVKSTEKARREVGALADFNNPNIVRYFSSWEEDTAYKHESSESFSDSGSGPGTKFLYIQMEFCEGNTLRVWIKERNSSNKQSPERRTEAAQIYRQVLKAVEYIHSKLLIHRDLKPPNIMFSSEGRVKVGDFGLVTAAENENEEQLLERTKRTGTRTYMSPEQMNQTTYDRKVDIYALGLIYFELVWNLGTMHEKEKIWDKLRVRVFPVQFTKMFIFEHKLMERMLSPRPEDRPDATDLILDLDQHYTLLKTDQDLRTV
Protein: Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein) (P03415)
Organism: Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus)
Function: Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_04202}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_04202}. Note=Largely embedded in the lipid bilayer. {ECO:0000255|HAMAP-Rule:MF_04202}.
Interaction partners:
Sequence:
MSSTTQAPEPVYQWTADEAVQFLKEWNFSLGIILLFITIILQFGYTSRSMFIYVVKMIILWLMWPLTIVLCIFNCVYALNNVYLGFSIVFTIVSIVIWIMYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGTVYVRPIIEDYHTLTATIIRGHLYMQGVKLGTGFSLSDLPAYVTVAKVSHLCTYKRAFLDKVDGVSGFAVYVKSKVGNYRLPSNKPSGADTALLRI
Protein: Golgi SNAP receptor complex member 1 (Probable 28 kDa Golgi SNARE protein) (Q9VE50)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Secretory 22, isoform B
- Syntaxin-5
- BET1 homolog
- LD34211p
- Probable Golgi SNAP receptor complex member 2
- Protein sly1 homolog
- LD23667p
- General vesicular transport factor p115
- Golgi matrix protein 130 kD
- HL02043p
Sequence:
MGGSSYDVLRKQARSLENEIDLKLVAFSKIGAGSGGGGSGGLGGVDTSPLLGEHVFDSLSEEIEQMLEKLSSLNESMSDLPASGAAAMHTLQRHREILQGYRQEFNKICANHTMRIEREELLRGSGLATSSGSPSISGLNRREMYLKESGHLNSASHLVNDQINIAIETRDHLHAQRQAFKRLQTRFNDISNRFPLISSLIQRINIKKRRDSLILGAVIGFCVILLLLYAFN
Protein: COPI associated protein (Q38EB4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKGGETAAGVAETGSKQSKEGVVDSKGDAWSLVFLILSTIAMALVISSSLVTLVVRNNTVADTFLELYMLVFAFLGLSAELRRFEGIRRGVYLWLRYFYFLTTYSGRGLFYIFLGAIAVGGTPLRYTSCVITTVLGFLMFVVNCFVNLPVYKDQ
Protein: Delta-like protein A (DeltaA) (Q6DI48)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell fate. Plays a role in angiogenesis.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Notch receptor 3.
- Notch receptor 1b.
- Transcription factor HES-5
- E3 ubiquitin-protein ligase mib1
- Neurogenin-1
- Ankyrin repeat and SOCS box protein 11
- Neurogenic locus notch homolog protein 2 precursor
- Achaete-scute homolog 1a
Sequence:
MGRHLLLLLFSILYMLLCQASSSGVFELKLQEFLNKKGVQGNKNCCKGGLTTSYQQCECKTFFRICLKHYQPNASPEPPCTYGGTVTPVLGSNSFQVPDTLPDGSFTNPIRMNFGFTWPGTFSLIIEALHADSKEDLTTENPERIISTMTTQRHLTVGEDWSQDLHSVGRTELKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEIICDAGWKGQYCTEPICLPGCDEEHGFCEKPGECKCRVGFKGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCLNGATCSNTGQGSYTCSCRPGFSGASCEIEVNECTGNPCRNGGSCTDMENTYSCTCPPGFYGKNCELSAMTCADGPCFNGGRCADNPDGGYFCQCPTGYAGFNCEKKIDHCSSSPCSNGARCVDLVNSYLCQCPDGFTGMNCDRAGDECSMYPCQNGGTCQEGASGYMCTCPPGYTGRNCSSPVSRCQHNPCHNGATCHERNNRYVCACVSGYGGRNCQFLLPDRASQIASDVPWTAVGSGVLLVLLLVVACAVVVVCVRSKVQQRRRDREDEVANGENETINNLTNNCHRDKDLAVSVVGVAPVKNINKKIDFSSDHDDLSLTTEKRSYKTRHAPADYNLVHEVKFEVKHEVKLEHAGKETTMANELSDSCEDIKCQSLQDSSECTEEKRRKRLKSDASEKSKYSESRYSESKYSESKYSESKYSDVSLYSESACASACASASTSACVDTKYKSVMVMSEEKDECVIATEV
Protein: Ferredoxin-1 (Ferredoxin I) (P0A3C8)
Organism: Nostoc sp. (strain ATCC 29151 / PCC 7119) (Anabaena sp.)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Interaction partners:
Sequence:
MATFKVTLINEAEGTKHEIEVPDDEYILDAAEEQGYDLPFSCRAGACSTCAGKLVSGTVDQSDQSFLDDDQIEAGYVLTCVAYPTSDVVIQTHKEEDLY
Protein: Heparan-sulfate 6-O-sulfotransferase 2 (HS 6-OST-2) (HS6ST-2) (EC 2.8.2.-) (Q800H9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- D-glucuronyl C5-epimerase B
- [heparan sulfate]-glucosamine N-sulfotransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- Extracellular sulfatase Sulf-1 isoform X1
Sequence:
MDGKSNYSRLLIALLMILFFGGIVLQYICSTSDWQLLHLASLSSRLGSRAPGDRLNGAGAGDPYSSEDGALVRFVPRFNFTTKDLSRAVDFHIKGDDVIVFLHIQKTGGTTFGRHLVRNIQLERPCECHAGQKKCTCYRPGKRDTWLFSRFSTGWSCGLHADWTELTNCVPSFMSNRESQERRMTPSRNYYYITILRDPVWRYLSEWRHVQRGATWKASKHMCDGRLPTLTELPSCYPGDDWSGCSLEEFMVCPYNLANNRQTRMLADLSLVGCYNLTVMSENQRWAMLLESAKRNLRNMAFFGLTEYQRKTQYLFEHTFRLSFIAPFTQLNGTRAASVEVEPETQRRIRELNQWDVELYEYARDLFLQRFQFARQQERREARQRRIQERRKLRAKVKSWLGVTGKAVFKPTKEPPMTEQSPAFAEEKQADAERTLESETEGQVEENWLEEDDGEIMLDYLENVEQWR
Protein: Ferric uptake regulation protein (Ferric uptake regulator) (P0A9A9)
Organism: Escherichia coli (strain K12)
Function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon.
Subcellular location: Cytoplasm.
Interaction partners:
- Flavodoxin 1
- Uncharacterized protein YbfE
- fur leader peptide
- Thioredoxin 1
- Alkyl hydroperoxide reductase C
- Transcriptional regulator MntR
- Thiol peroxidase
Sequence:
MTDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHEGK
Protein: Coagulation factor XIII B chain (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain) (Q07968)
Organism: Mus musculus (Mouse)
Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05160}.
Interaction partners:
- Coagulation factor XIII A chain
- Fibrinogen alpha chain
- Prothrombin
- Fibrinogen gamma chain
- Homogentisate 1,2-dioxygenase
- Histidine-rich glycoprotein
- Fibrinogen beta chain
- UDP-glucuronosyltransferase 3A2
- Heparin cofactor 2
- Vitamin K-dependent protein C
Sequence:
MMTLRHLPFILLLILSGELYAEEKQCDFPTVENGRIAQYYYTFKSFYFPMSVDKKLSFFCLAGYATESGKQEEQIRCTAEGWSPNPRCYKKCLKPDLRNGYVSNDKVLYKLQERMSYGCSSGYKTTGGKDEEVVHCLSAGWSSQPSCRKEQETCLAPELEHGNYSTTQRTFKVKDIVAYTCTAGYYTTTGKQTGEAECQANGWSLTPQCNKLMCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPICEGRRNRCPPPPVPLNSKIQPHSTTYRHGERVHIECELNFVIQGSEELLCENGKWTEPPKCIEEKEKVACEQPPSVENGVAHPHSEIYYSGDKVTYRCGGGYSLRGSSTITCNRGRWTLPPECVENIENCKPPPDIANGVVVDGLLASYTTGSSVEYRCNEYYLLKGSETSRCEQGAWSSPPVCLEPCTIDVDHMNRNNIQLKWKYEGKILHGDLIDFVCKQGYNLSPSIPLSEISAQCNRGDVRYPMCIRKESKGMCASPPVIRNGDIVSSAARTYENGSSVEYRCFDNHFLQGSQNVYCVDGVWTTPPSCLEPCTLSFVEMDKNYLQLKWNFDNRPLILHGEYIEFMCKRDAYISETSIAGSVLRVQCDRGRLKYPKCTPRDRRLSFQEALRTRRQMEKR