wanglab/gogpt-training-data huggingface dataset:
Protein: ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) (Q03265)
Organism: Mus musculus (Mouse)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17438143}; Peripheral membrane protein {ECO:0000269|PubMed:17438143}; Matrix side {ECO:0000250|UniProtKB:P19483}. Cell membrane {ECO:0000250|UniProtKB:P25705}; Peripheral membrane protein {ECO:0000250|UniProtKB:P25705}; Extracellular side {ECO:0000250|UniProtKB:P25705}. Note=Colocalizes with HRG on the cell surface of T-cells. {ECO:0000250|UniProtKB:P25705}.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
- ATP synthase peripheral stalk subunit d, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
Sequence:
MLSVRVAAAVARALPRRAGLVSKNALGSSFVGARNLHASNTRLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDVVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDSFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQSLLGNIRSDGKISEQSDAKLKEIVTNFLAGFEP
Protein: Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2) (Q9NQ40)
Organism: Homo sapiens (Human)
Function: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:21512156, ECO:0000269|PubMed:24264046}; Multi-pass membrane protein {ECO:0000269|PubMed:20463145}. Cell membrane {ECO:0000269|PubMed:22273710, ECO:0000269|PubMed:27702554}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:29428966}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:29428966}; Multi-pass membrane protein. Cytoplasm {ECO:0000269|PubMed:29428966}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:29428966}.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
- Deleted in lung and esophageal cancer protein 1
Sequence:
MAFLMHLLVCVFGMGSWVTINGLWVELPLLVMELPEGWYLPSYLTVVIQLANIGPLLVTLLHHFRPSCLSEVPIIFTLLGVGTVTCIIFAFLWNMTSWVLDGHHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISDSVPSPVPTRETDIAQGVPRALVSALPGMEAPLSHLESRYLPAHFSPLVFFLLLSIMMACCLVAFFVLQRQPRCWEASVEDLLNDQVTLHSIRPREENDLGPAGTVDSSQGQGYLEEKAAPCCPAHLAFIYTLVAFVNALTNGMLPSVQTYSCLSYGPVAYHLAATLSIVANPLASLVSMFLPNRSLLFLGVLSVLGTCFGGYNMAMAVMSPCPLLQGHWGGEVLIVASWVLFSGCLSYVKVMLGVVLRDLSRSALLWCGAAVQLGSLLGALLMFPLVNVLRLFSSADFCNLHCPA
Protein: Centrosomal protein 290 (S4R322)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
DHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEIIAQEFLIKEAECRNADIELEHHRSQAEQNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAEV
Protein: Cyclin-dependent protein serine/threonine kinase inhibiting protein (A0A1D8PQH4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Rho family guanine nucleotide exchange factor
- Mitogen-activated protein kinase
- G protein subunit beta
- Guanine nucleotide-binding protein subunit gamma
- Extracellular signal-regulated kinase 1
- Cyclin-dependent kinase 1
- SCF ubiquitin ligase complex subunit
- Cullin
- E3 ubiquitin ligase complex SCF subunit
- SCF ubiquitin ligase complex subunit
Sequence:
MRKSFHSPKKRTSTSTKLESILPFPAETKKYNNIKCSLCQELLSLTLPGELIVSLECGHMSHKNCLSLIQSVPVCSECNVMSNYDYPPFTPVDQIQSPAKLNTQLETPSFTSSDQTIYNPRVTCTSEISEVTLTPPYEIAYVLNVQAPLIFNAHKPTLEDLQLKERVEEFLKVHLDTDKDVGQLVIFDILEVSVTGKSWDSALVCLFENYFLIYENELLVGIISVQHDISSVDVDEELILNLAKDSLPELRLRHSNKLVVQKWGTLLLEIIDNESVVTNIYQLTNTYWTHLPPEICVPQNLTKLNNAILSGTTISNSDIARILPTPKQLSLNLILALPLVNQTSLTDLEYKTQIQQIFQKTLHELRPNDKLGVIFLGIDGSKKPCAKGSFVGCTEPSWSEWKQVIRDITIVPNSFQSNLQEINVAIEKCMELYPFIPRTTSSVNKFLILSPNTYSQSPKDAPKSKFIDAINEKLSCTIVCVGSTYGNYQPFKSITTFGTPFLRFESFAKFGSLLVYYINENLHKICIPKLTLTLKASQGFRFTDLDSRGAIDGSQLTLTIKDIVPQTQKSIVLKVQANPQFVASKYQTLPIFEYDGYWFYEKYLDTKLISTRVKIGVSQQPPTPIDAEARGSFTEYYLDIPLLPPVSPARDAVFAKRQTELTIINSLKKSIASGESQVSSDIIKSCISLAHGLIRTSLEGSTKSHTNESSPECEYSMLQLLMAVRYTDKGNVEYIDFLVNHMKSIAKLLESDLDAGKLRCSDLMNSLI
Protein: Outer dynein arm protein 1 (Docking complex component 2) (A8JF70)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Component of the outer dynein arm complex required for assembly of the outer dynein arm-docking complex (ODA-DC) and the outer dynein arm onto the doublet microtubule.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:11907279}.
Interaction partners:
Sequence:
MPSADATRGGGSAGSMGKGTLGAGDTLGHKSVLDKQRAAIEKLRAQNEQLKTELLLENKFSVRPGDPFAQALINRLQDEGDMLARKIVLEMRKTKMLDQQLSEMGSTLTTTRNNMGGIFSAKEQSTAVQKRIKLLENRLEKAYVKYNQSITHNKQLRESINNLRRERIMFESIQSNLERELAKLKRDMADMIQQANGAFEAREKAIGEMNALKAQADKEQQGFEEEWRQLTTIIEEDKKERERARAQELAMRERETQELLKMGTLSSAEKKKRITKGSWNVGYNKAMAQNVAAEKVEMYGQAFKRIQDATGIEDIDQLVNTFLAAEDQNYTLFNYVNEVNQEIEKLEDQINIMRGEINKYRETGRELDMTKSRELTEEEARLAASEAQSQLYEKRTDSALSMTTALKAGINDLFERIGCNTPAVRDLLGEEGVTEANLTAYLGIIEQRTNEILQIYAKRKAQQGTDGLAEALLAQPLTQPGNRIIIEPPSTTQEEEVEGLEPEPVEEDRPLTREHLESKVQRTLPRKLETAIKVRPAGADATGGKRGSPTRR
Protein: Serine-rich adhesin for platelets-like protein (F4J8I0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pre-mRNA-splicing factor 38
- Protein STABILIZED1
- Pre-mRNA-processing protein 40C
- Microfibrillar-associated protein-like protein
- Microfibril-associated protein-like
- Sm-like protein LSM2
- Sm-like protein LSM8
- Sm-like protein LSM4
- Protein TONNEAU 1a
- At2g32600/T26B15.16
Sequence:
MVEMEAVERKRSRGGFLNMFDWPGKSRKKLFSSSSSSSKLSEGSKQEKQNAQNPSKSWPSLIEGDEIGKNSTYNPRSDSSCSTSTPTSDDGQGSKAPSVVARLMGLESIPVPNALEPRRNPDFDPYFLRSSRKASTWDAYENLGYVNLRSDYDGISWDHLDSRMNKECNRPIDRFQTETLPPRSAKPIPVTHNRLLSPIRSPGFVQSRNPASVMEEASRMIEPSPRVVAKTRFSSSDSSSSLPMKIRDLKEKLEASQKGQSPQISNGTCNNKCFRGKQDEKRTTLPLKTQERNNLLGESRFGGSKGKVKPPSVSAHAKANTIHKRDSSMLSNGYRDQKKKVETKNRIVKSGLKESSASTRKTVDKPNNQKQNQFAETSVSNQRGRKVMKKVNKVLVENGTTTKKPGFTATSAKKSTSSSLSRKKNLSRSKKPANGVQEAGVNSDKRIKKGEKVIKCNITVDGGLKTGDDDRKKDMDVISFTFSSPIKGLSSDSQYFLKKNDQDAESALCFNKIDSDSLNFLLEKKLRELTSKMESSCSSLTQEEESSGSITKDWVNGTRSLPSDDQDNGLSESESDSDYSSSFYKKKIFQAEDDEEVNSFSTAENLQISCSTSFSSSRNDYHHNIEETELSESVALSEAEEGHDWELEYITEIIASGQLMIKEFSLGMATDILPLSLFDETEGKRDARGKIERKTLFDLVNQWLTLKCEQMFMGTCKGVLGKQDIFLERREILADQVLKEAQGLKKMREMMMDELVDNDMSSCEGKWLDYMRETYEEGIEIEEEIVSELVDDLINDLIMCC
Protein: guanylate cyclase (EC 4.6.1.2) (H2L2D1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MYGLVIEGVRFMIQENWGPQVLLQVQKLTSLSEKSVSTHDQYSEHVVPQMFKAIHEITGTPYEQIGVLAGRFFVQFLIRNGYGDLMNVMGRRFSDFIKGLDNIHEYFRFSYPKLRAPSFYCKSESEDGLILHYRSRRTGYLSYVIGQLVELARVFYQLDIGIQVLKKKEKGRFTFVVLKISFDNVGLGQDLKLKERVKNLNEYLPVDTKSFLQMFPFHIAFNKKLEILMAGQGLLNLMPNIQGLLMTDVFDLQRPCIKFTAEGIMVHQNCVFQIESLHPVVKQTEENITVQINDITEDKVSLEKKTVMDNEYGLESLPYVTLRGPITVLKSSETFLLLATCVVDTLDTMFKMGLYLNDFGESDCNREIIMATIQKSDTLKTMLENEKRRSEVLTEMTREISEAKKTARTLLTQMMPYEVAQTMMRSGSVDHCEAFECVSIGFIRVCDFSKISLFIEAFEVVNLLNTIYSHLDSIVDTHGVYKVETIGESYMISAGCPYRDDYDAEMVSDCCLEMVSHIKSFEYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVYEIEKKKGRARYKKSDPLRKKMVAEKKEAEELLDEDNEGHRSSALSRMSLGESIDSSSSRRGSLSGSQLELNKTIAQTIELTSKASAALDLNMQDENNRPPTWSASHSQDIRKPRKTESKITLNSRLSSSDLAVSRVETSKDSDGETPRPTSSELKEVNRIREEALAQEKEEERTTKEENQKIEEVGEDHVSEATSLLDSEVSHGDNNISFSQMPSDSIPHEDRTSLPSATPSEIGDAISKKKLEKEDSNSSMSSLDERTTVSAKPTTTRRLLNQKDLEKEKKRSSMAGSSVTSSSAHSHSIRSKKDTRDKSRCKCEDIRADNKLKTKVCSIM
Protein: Importin subunit beta-2 (Importin-104) (Karyopherin subunit beta-2) (Karyopherin-104) (Transportin) (TRN) (P38217)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Required for nuclear transport of NAB2, HRP1/NAB4 and TFG2. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. Efficient GTP-Ran-mediated substrate release requires RNA. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8849456}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:8849456}. Nucleus {ECO:0000269|PubMed:8849456}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:8849456}.
Interaction partners:
- Nuclear polyadenylated RNA-binding protein NAB2
- Importin subunit beta-4
- GTP-binding nuclear protein GSP1/CNR1
- Importin beta SMX1
- Importin subunit beta-3
- Exportin-1
- mRNA transport regulator MTR10
- Nonsense-mediated mRNA decay protein 5
- Nuclear polyadenylated RNA-binding protein 4
- Importin subunit beta-5
Sequence:
MASTWKPAEDYVLQLATLLQNCMSPNPEIRNNAMEAMENFQLQPEFLNYLCYILIEGESDDVLKQHYSLQDLQNNRATAGMLLKNSMLGGNNLIKSNSHDLGYVKSNIIHGLYNSNNNLVSNVTGIVITTLFSTYYRQHRDDPTGLQMLYQLLELTSNGNEPSIKALSKIMEDSAQFFQLEWSGNTKPMEALLDSFFRFISNPNFSPVIRSESVKCINTVIPLQTQSFIVRLDKFLEIIFQLAQNDENDLVRAQICISFSFLLEFRPDKLVSHLDGIVQFMLHLITTVNEEKVAIEACEFLHAFATSPNIPEHILQPYVKDIVPILLSKMVYNEESIVLLEASNDDDAFLEDKDEDIKPIAPRIVKKKEAGNGEDADDNEDDDDDDDDEDGDVDTQWNLRKCSAATLDVMTNILPHQVMDIAFPFLREHLGSDRWFIREATILALGAMAEGGMKYFNDGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPWILQDHTEFLIPVLEPIINTLMDKKKDVQEAAISSVAVFIENADSELVETLFYSQLLTSFDKCLKYYKKKNLIILYDAIGRFAEKCALDETAMQIILPPLIEKWALLSDSDKELWPLLECLSCVASSLGERFMPMAPEVYNRAFRILCHCVELEAKSHQDPTIVVPEKDFIITSLDLIDGLVQGLGAHSQDLLFPQGTKDLTILKIMLECLQDPVHEVRQSCFALLGDIVYFFNSELVIGNLEDFLKLIGTEIMHNDDSDGTPAVINAIWALGLISERIDLNTYIIDMSRIILDLFTTNTQIVDSSVMENLSVTIGKMGLTHPEVFSSGAFANDSNWNKWCLSVNALDDVEEKSSAYMGFLKIINLTSTEVTMSNDTIHKIVTGLSSNVEANVFAQEIYTFLMNHSAQISAINFTPDEISFLQQFTS
Protein: KLF transcription factor 1 (G3V6F3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Erythroid transcription factor
- TAL bHLH transcription factor 1, erythroid differentiation factor
- LIM domain binding 1
- Zinc finger protein, multitype 1
- Erythropoietin receptor
- Rhombotin-2
- Transcription factor PU.1
Sequence:
GRRERGGLRPRVDSSQSWPQLRLSYPPSVHSPPWDSSWTPRRTSSSRGCFRARYPVPTIQAVRSLPQWWRSEETQDLGPGPPNPTEPSFHVSLKSEDPPGEDDERDVTCAWDPDLFLTNFSGPEPPSTPRTCALAPSGGPVAQFAPPESLSAYAGGPGLVTGPLGSEEHAGWAHPTPRPPTPEPFVAPVLAPGLAPKAQPAFSESRAVSAGGFFPRAGLAVPAAPSAPYGLLSGYPALYPAPQYQGHFQLFRGLAAPSAGPTAPPSFLNCLGPGAVGTELGATAIAGDAGLSPGAAPPKRSRRTLAQKRQAAHTCGHEGCGKSYTKSSHLKAHLRTHTGEKPYACSWDGCNWRFARSDELTRHYRKHTGHRPFCCGLCPRAFSRSDHLALHMKRHL
Protein: Uncharacterized protein, isoform D (M9PDD2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTLLGPSAPGMAFMMKKKKYKFNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEFPCKMSANASTGVLDPCHLRISIRKEMKGGRSYYKLGFIDLNLAEFAGAGLTSRRFLLEGYDSRHRLDNSMLRVSIKMHMLSGDILFKAPTPNLKSKQSKPSIDDFSNAATGVGLQIPTATALPSIGGGSGGASVSLGGSGVTLGGIPGNQSLPGTRPVSTTKEEDIDNQALIAAIVTDSGLSESSESGVTLTTDNLQQHGSVVVANPISPVTQALPQLGIIGSNNYGTTGGAIGFTGAGNATLIEMGHSRNSSNTSQMSKGSGYSSFSHSQHSRQSSEGDSGHARNFSGVPRRLFDGNITTAGQNSNMGAVSTNRQQQPCAPGTNSFIGSNSSPSGTLASIHSSHSASSSNGSNSSSSGAVITFQCTAGSGQDTVDSANHQQQMTVGSPNGHGSNPRLGNVMSGDVISSMAASPTDACSIRSNPSAASLLLSTSAAAAEASALASATTMSVSGATLSPLATTQIIRRPSITMMNPSSGSLVISETGSLDRTKSSGEKRKKGALDDGPRVSDRVEETRVNPDSLIDEILKDTKLDQLEESAETSGLQLYIARDGTASLGGHEVKSSVRAGALKQVVMQDRR
Protein: Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (P61150)
Organism: Rattus norvegicus (Rat)
Function: Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Sodium channel protein type 5 subunit alpha
- Fibroblast growth factor receptor 1
- C-Jun-amino-terminal kinase-interacting protein 2
Sequence:
MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRPEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST
Protein: E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31) (Q8R0K2)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BZY9}. Mitochondrion {ECO:0000250|UniProtKB:Q9BZY9}. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria. {ECO:0000250|UniProtKB:Q9BZY9}.
Interaction partners:
- Mitochondrial antiviral-signaling protein
Sequence:
MAGQPLACQLQEEVTCPICMEILQDPVTIDCGHNFCLQCISQVGKTSEKIQCPLCKLSVNKNTFRPNKLLASLAEKIQSMDPADIQAEKEDSRCQRHKEKLHYFCEQDGAFLCVVCRDSKDHKSHNVTLIDEAAQNYKVQIESQAQDLGQKDKKIIEEKKQGEGAIWAFRAQVDLEKLKIHEEFKLLRQRLDEEESFLLSRLDWLEQQGAKQLRQYVTVTEKQLNSLRKLTKSLKIRLQSSSMELLKDIKDALSRGKEFQFLNPNPVPEDLEKKCSEAKARHESIIKTLTELKDDMNAEGKRDKSAFMNSLNKEEKESWSLLQKNNSVLPTSVPVTLDKSSADPDLTFSQDLKKVTLYIVAGKASNRQAKPRPFYPFHCVRGSPGLSSGRQVWEAEIRGPSGGACIVGVVTELARGAQSQTVSAQSYIWALRISPSGCQPFTNCKAQEYLQVCLKKVGVYVNHDCGEVVFYDAITSKHIYTFQTSFDGKVFPLFGLQVACSHITLSP
Protein: Transcription factor MYB92 (Myb-related protein 92) (AtMYB92) (Q9SBF3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase 5
Sequence:
MGRSPISDDSGLKKGPWTPDEDEKLVNYVQKHGHSSWRALPKLAGLNRCGKSCRLRWTNYLRPDIKRGRFSPDEEQTILNLHSVLGNKWSTIANQLPGRTDNEIKNFWNTHLKKKLIQMGFDPMTHRPRTDIFSGLSQLMSLSSNLRGFVDLQQQFPIDQEHTILKLQTEMAKLQLFQYLLQPSSMSNNVNPNDFDTLSLLNSIASFKETSNNTTSNNLDLGFLGSYLQDFHSLPSLKTLNSNMEPSSVFPQNLDDNHFKFSTQRENLPVSPIWLSDPSSTTPAHVNDDLIFNQYGIEDVNSNITSSSGQESGASASAAWPDHLLDDSIFSDIP
Protein: Cytosolic iron-sulfur assembly component 2A (Family with sequence similarity 96, member A, isoform CRA_a) (H0YKV4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDSK
Protein: Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (O70514)
Organism: Mus musculus (Mouse)
Function: Acts as a carrier protein that releases fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity).
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:Q14512}. Cell membrane {ECO:0000250|UniProtKB:Q14512}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14512}. Note=Extracellular and plasma membrane-associated. {ECO:0000250|UniProtKB:Q14512}.
Interaction partners:
- Fibroblast growth factor 1
- Fibroblast growth factor 10
- Fibroblast growth factor 22
- Fibroblast growth factor 2
- Fibroblast growth factor 7
- Fibroblast growth factor 3
- Fibroblast growth factor 18
- Fibroblast growth factor 20
- Fibroblast growth factor 5
- Fibroblast growth factor 17
Sequence:
MRLHSLILLSFLLLATQAFSEKVRKRAKNAPHSTAEEGVEGSAPSLGKAQNKQRSRTSKSLTHGKFVTKDQATCRWAVTEEEQGISLKVQCTQADQEFSCVFAGDPTDCLKHDKDQIYWKQVARTLRKQKNICRNAKSVLKTRVCRKRFPESNLKLVNPNARGNTKPRKEKAEVSAREHNKVQEAVSTEPNRVKEDITLNPAATQTMAIRDPECLEDPDVLNQRKTALEFCGESWSSICTFFLNMLQATSC
Protein: Glycosyl hydrolase family protein (Q0WNW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSRDSVRIVGVLLWMCMWVCCYGDGEYLLYKDPKQTVSDRVADLFGRMTLEEKIGQMVQIDRSVATVNIMRDYFIGSVLSGGGSAPLPEASAQNWVDMINEYQKGALVSRLGIPMIYGIDAVHGHNNVYNATIFPHNVGLGATRDPDLVKRIGAATAVEVRATGIPYTFAPCIAVCRDPRWGRCYESYSEDHKVVEDMTDVILGLQGEPPSNYKHGVPFVGGRDKVAACAKHYVGDGGTTRGVNENNTVTDLHGLLSVHMPAYADAVYKGVSTVMVSYSSWNGEKMHANTELITGYLKGTLKFKGFVISDWQGVDKISTPPHTHYTASVRAAIQAGIDMVMVPFNFTEFVNDLTTLVKNNSIPVTRIDDAVRRILLVKFTMGLFENPLADYSFSSELGSQAHRDLAREAVRKSLVLLKNGNKTNPMLPLPRKTSKILVAGTHADNLGYQCGGWTITWQGFSGNKNTRGTTLLSAVKSAVDQSTEVVFRENPDAEFIKSNNFAYAIIAVGEPPYAETAGDSDKLTMLDPGPAIISSTCQAVKCVVVVISGRPLVMEPYVASIDALVAAWLPGTEGQGITDALFGDHGFSGKLPVTWFRNTEQLPMSYGDTHYDPLFAYGSGLETESVASIVARSTSASATNTKPCLYTVLVSATLCLFIFPSLSRL
Protein: Sialic acid binding Ig-like lectin H (Siglec-H) (Siglech protein) (Q4QQK7)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- Bone marrow stromal antigen 2
- Integrin alpha-X
- Receptor-type tyrosine-protein phosphatase C
- P2Y purinoceptor 12
- Integrin alpha-M
- CX3C chemokine receptor 1
Sequence:
MLLSRLLPLLWVLKWASGNCFILPREVIGTYPSLTLELQSVTVQEGLCVLVPCHLIEYPMNRWSDAAFGYWFHEGENTHPDSLVATNKPYQLVQKEMQSRFHFSGDCSLDIRDAQKGDNGSYFFRLEKGGKTWNFCEERISVHVTDLTHSPNISIPQTLELGRPTNVMCSVPWACERGTPPIFSWMSAALISLGPTTTLSSVLTLTPRLQDHGTNLTCQVTFPGAGVTVQKTIQLNVTYNSQNSTAHVSGRVGPGKPRPLADVVQVAMGEAAIKFLLLGICFFFLSKRSHTKRVERPATHMDQAHAVMD
Protein: Nectin cell adhesion molecule 3 (A0A8I6ABQ5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MYLSCFTVFTAILLSPDLNSNAEYFIGLRHTDIPLKQTSSIAVAGAVIGAVLALFIIAVFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPVYEERIPSLPQKNRLFQTERLPLQTQFKEKGAGGLQPPNGPIRRLDYEDENTVQEDGTQQMCPLYNQMCHQDRSPHQHRPRNPERLYINPREHYV
Protein: Dachs, isoform D (LP16090p) (B5RJR1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATLGLSKVFILDKYFTELQKFWETEKKLQDASSSNEAVHLQQRLKSLSTELVTLRNRLHVGHGPGQGQSQGNGAQPVAPAPNAGPKANNFDLNASSPNLNLSSSGAGLSASAVQQHTNGHHTTSKNHSFSHTLPANSGSGGGGGAGGGAVVSARNTSIPHPLPHQLAEKPGLSHQQSGSGHGQSTGTLPHMSGMGSILGQNSHSHAPVNNNSNNSNTLPMRTSNSGHLGINGGGVGHHLSHAHSQQLPFIPQSKHTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTDGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFIDGGGLEVDVKGETELNSVASLLGVPPAALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSVRGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKKMGNGGAKRSKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISVPRLSAKTTSLGIGGTVARPRPQPIAGTPPPDPQEKCDQKIIQQTCNLFGLDLERPPPVPPSRSYTITGNSKISYPQNRVMKMNFPEEGQSEAPQLKKGEAVTVVGASTVRGHLMVEHKGQSFHVPFQFMTLSK