wanglab/gogpt-training-data huggingface dataset:
Protein: WASH complex subunit 4 (WASH complex subunit SWIP) (Q3UMB9)
Organism: Mus musculus (Mouse)
Function: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Subcellular location: Early endosome {ECO:0000250|UniProtKB:Q2M389}.
Interaction partners:
- WASH complex subunit 1
- WASH complex subunit 5
- WASH complex subunit 3
- WASH complex subunit 2
- Sorting nexin-27
- DnaJ heat shock protein family
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha-1
- TBC1 domain family member 23
- Biogenesis of lysosome-related organelles complex 1 subunit 2
Sequence:
MAVDTLSPDWDFDRVDDGSQKIHAEVQLKNYGRFLEEYTSQLRRIEDALDDLIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDSSMVEGDCQIQMGRFVSFLQELSCFVTRCYEVVMNVIHQLAALYISNKIGPKIIETTGVHFQTMYEHLGELLTVLLTLDEIVDNHVTLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGISVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTVDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIHKMPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLNKDVQSYYVFVSSWMMKMESMLSKEQRMDTFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLIELLKAIEHMFYRRSMVVADSVSHITQHLQHQALSSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQAQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHSRHLESHELLLDCYDKEIMDILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGRKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGITPEGQSYLDQFRQLISQIGNAMGYIRMIRSGGLHCSSNAIRFVPDLEDIVSFEELVKEEGLAEETLRAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKLGAAFTDDGFAMGVAYTLKLLDQYQEFDSLHWFQSVREKYIKEIRAVAKQQNVQSTSQDEKLLQTMNLTQKRLEVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEEETKTSNGDGPESTVSADPVVK
Protein: Pectate lyase B (EC 4.2.2.2) (Pectin lyase) (EC 4.2.2.10) (D3JTC2)
Organism: Paenibacillus amylolyticus
Function: Catalyzes the depolymerization of both polygalacturonate and pectins of various methyl esterification degree, with an endo mode of action. Shows the highest activity on 20 to 34% methylated pectin but retains 67%, 51%, 25%, and 1% of its maximum activity on polygalacturonate and 8.5%, 55 to 70%, and 90% methylated pectin, respectively.
Subcellular location: Secreted {ECO:0000269|PubMed:20622125}.
Interaction partners:
Sequence:
MKKTVRSLCSTALALTLGFTLLSGPASVQAAGNADYNLAGFSQGNTGGGIISESNTSTYKKVYNATDLALALKKNSGVKVVEIMNDLDLGWNEIPSAAQTSPFAKHNDALTHPVLKQTGVSKITVDGFNGLTIFSANGSKIKHAAITVKRSSNVIIRNLEFDELWEWDESTKGDYDKNDWDYITLEDSSGVWIDHCTFNKAYDGLVDSKKGTSGVTISWSTFKGDDGSANSWVTRQINELEANKASYPMYNYLRSSAVGLSKQDVIAISGPQKKGHLVGATSLESANANLSITLHHNLYKDIQDRMPRLRGGNAHAYNIIMDAADARSAQSRITSAMATAIASKGYKFGITSNGAISTESGAVLVEKSVIKDVQXPCTQQSDRSDQRHVHR
Protein: Cysteine-rich motor neuron 1 protein (CRIM-1) (Q7T3Q2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
Sequence:
MASSRMYLLVKCMLILQLMVLIAKNSRALICLPCDKSKCEEPKPCTGSVVLGICGCCSVCAKQKNESCGGVYGLYGTCDRGLRCVIRPPLNGGSITQYEVGNCEDENWDDDQLLGFEPCNENLVTGCNIIDGKCECDSVRTCNNPFEFASQEACQTALQKIEEERPDCSKARCEVQFSPRCPEDSILIEGYAPPGECCPLPSRCVCSPAGCLRKVCQPGHLNILVSKSSGKPGECCDLYECKPVFSVDCSTVECPPVKPVQCPADSYETQVRLTADGCCTLPTRCECLPGLCTFPQCSAGMSPQVMSRGDGTPGRCCDVFECVNETKPACTLNGVEYHDGDMFRMDACRFCRCQGGVSVCFTAQCGVLHCERYYVPDGECCPVCEDPIYPVLSLAGCYVNGQILAHGDHWREDDCTFCQCVSGDARCVAAACGHSCLNPVTVPGECCPVCEEPTYITMAPPACGSLDNCTLLEQSCAFGFRLDPSGCRTCACKSREELCGGLMASCTLKCPFGFQTDIHGCDVCQCRPRHKKCKAVACAKDCPFGYIKNKHGCDTCRCKKCPELPCDKACPMGFQHDELGCLICQCRDQSSSSVTPAVKLGSCLSMDGRRHENGQSWHDGCRDCYCHAGREMCALISCPVPPCDNPTIRPGHCCPTCPEESSSHKPELSEASVCLAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCHSPIRTQDSCCPHCPDDPVTPQTPSNDSMPSYCRNEDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNCARPVLRKGQCCPYCLDATPRAVCHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTVEGSCCPMCPESYAPTNVPIEKTDQRGDKSRHQPAWPTHSENDVMPQFRGEFGSLQMPYLDGKTPLPSEDAGLHWAWVALPVLMMMLTLAALLLVNQRKQWIPVPCYRTPNKSTCLNNQLVYVDCQKGTKVQVDSSQRMLRIADPDSRYSGYYSMQKHNNLQADNFYQTA
Protein: THAP domain-containing protein 5 (Q7Z6K1)
Organism: Homo sapiens (Human)
Function: Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.
Subcellular location: Nucleus {ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:21110952}.
Interaction partners:
- BRISC complex subunit Abraxas 2
Sequence:
MPRYCAAICCKNRRGRNNKDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQKKNLEDEKEVCPKAKSEESFVLNETKKNIVNTDVPHQHPELLHSSSLVKPPAPKTGSIQNNMLTLNLVKQHTGKPESTLETSVNQDTGRGGFHTCFENLNSTTITLTTSNSESIHQSLETQEVLEVTTSHLANPNFTSNSMEIKSAQENPFLFSTINQTVEELNTNKESVIAIFVPAENSKPSVNSFISAQKETTEMEDTDIEDSLYKDVDYGTEVLQIEHSYCRQDINKEHLWQKVSKLHSKITLLELKEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI
Protein: Large ribosomal subunit protein uL24m (39S ribosomal protein L24, mitochondrial) (L24mt) (MRP-L24) (Q9CQ06)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q96A35}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL19m
Sequence:
MRLSALLALASKATSSPFYRYGMSRPGSIADKRKNPPWSRRRPVVVEPISDEDWHLFCGDMVEILEGKDAGKQGKVVQVVRQRNWVVLEGLNTHYRYIGRTKDHRGTMIASEAPLLHHQVKLVDPVDRKPTEIQWRFTEAGERVRVSTRSGRIIPKPEFPRADGIVPETWTDGPKDTSVEDALERTYVPRLKTLEEDVMEAMGIQETRRFKKVYWY
Protein: Small ribosomal subunit protein eS28B (40S ribosomal protein S28-B) (S33) (YS27) (P0C0X0)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS26A
- Small ribosomal subunit protein uS2A
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS14B
- Small ribosomal subunit protein eS27A
- Small ribosomal subunit protein eS10A
- Small ribosomal subunit protein uS11B
- Small ribosomal subunit protein eS1A
- Small ribosomal subunit protein eS25B
Sequence:
MDSKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILVLMESEREARRLR
Protein: Required for drug-induced death protein 1 (Q9H7X2)
Organism: Homo sapiens (Human)
Function: Regulates drug efflux through modulation of ABCB1 localization and activity.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTVGARLRSKAESSLLRRGPRGRGRTEGDEEAAAILEHLEYADEAEAAAESGTSAADERGPGTRGARRVHFALLPERYEPLEEPAPSEQPRKRYRRKLKKYGKNVGKVIIKGCRYVVIGLQGFAAAYSAPFAVATSVVSFVR
Protein: Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) (Q8N357)
Organism: Homo sapiens (Human)
Function: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.
Subcellular location: Mitochondrion. Lysosome membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAWTKYQLFLAGLMLVTGSINTLSAKWADNFMAEGCGGSKEHSFQHPFLQAVGMFLGEFSCLAAFYLLRCRAAGQSDSSVDPQQPFNPLLFLPPALCDMTGTSLMYVALNMTSASSFQMLRGAVIIFTGLFSVAFLGRRLVLSQWLGILATIAGLVVVGLADLLSKHDSQHKLSEVITGDLLIIMAQIIVAIQMVLEEKFVYKHNVHPLRAVGTEGLFGFVILSLLLVPMYYIPAGSFSGNPRGTLEDALDAFCQVGQQPLIAVALLGNISSIAFFNFAGISVTKELSATTRMVLDSLRTVVIWALSLALGWEAFHALQILGFLILLIGTALYNGLHRPLLGRLSRGRPLAEESEQERLLGGTRTPINDAS
Protein: Meis homeobox 1 (A0A8I6GMM6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRAANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQAQMPPHPAQLRHGPPMHTYIPGHPHHPAVMMHGGQPHPGMPMSASSPSVLNTGDPTMSGQVMNIHAQ
Protein: Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2) (P11475)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (By similarity). Plays a role, in a LIF independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (By similarity). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61539}. Cytoplasm {ECO:0000250|UniProtKB:Q61539}. Chromosome {ECO:0000250|UniProtKB:Q61539}.
Interaction partners:
- Homeobox protein NANOG
- Transcription factor CP2-like 1
- Sal-like protein 4
- Nuclear receptor subfamily 0 group B member 1
- POU domain protein
- KLF transcription factor 5
- T-box transcription factor TBX3
- Integrator complex subunit 9
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear receptor corepressor 2
Sequence:
MSSEDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGMALGTHANGLDSPPMFAGAGLGGNPCRKSYEDCTSGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSENSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPDDVPEGDIKALTTLCDLADRELVFLISWAKHIPGFSNLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLAYAEDYIMDEEHSRLVGLLELYRAILQLVRRYKKLKVEKEEFVMLKALALANSDSMYIENLEAVQKLQDLLHEALQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
Protein: Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] (Q5E9F2)
Organism: Bos taurus (Bovine)
Function: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
Interaction partners:
- Biliverdin reductase A
- Ferrochelatase, mitochondrial
- Flavin reductase
- Frataxin, mitochondrial
- Ceruloplasmin
- Ceruloplasmin
- NADPH--cytochrome P450 reductase
- Kelch-like ECH-associated protein 1
- Nuclear factor erythroid 2-related factor 2
- Glutamate--cysteine ligase
Sequence:
MERPQPDSSMPQDLSEALKEATKEVHTQAENAEFMKNFQKGELTQEGFKLVMASLYHIYVALEEEIERNKENPVYTPLYFPEELHRRASLEQDMAFWYGPRWQEAIPYTQATKRYVQRLQEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALNLPSSGEGLAFFTFPNIASATKFKQLYRSRMNTLEMTPEVRQRVLDEAKTAFLLNIQLFEELQGLLTQKAKDHDPLQAPELHRRAGSKVQDLAPTKASRGKPQPSVLSQAPLLRWVLTLSFLVATVAVGLYAM
Protein: Serine/threonine-protein kinase Aurora-1 (AtAur1) (EC 2.7.11.1) (Aurora-like kinase 1) (Q9M077)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphorylates specifically 'Ser-10' of histone H3 in vitro and colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Colocalizes also with gamma-tubulin and function in microtubule organizing centers (MTOCs). In contrast with the mammalian B-type Aurora, AUR1 has no kinase activity toward 'Ser-28' of histone H3.
Subcellular location: Nucleus membrane. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, phragmoplast. Note=Nuclear membrane in interphase cells, spindle poles at prophase, mitotic spindle from metaphase to telophase and equatorial cell plate at telophase.
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Kinetochore protein NDC80 homolog
- Mitotic checkpoint protein BUB3.1
- Microtubule-associated protein RP/EB family member 1C
- Ubiquitin-conjugating enzyme E2 20
- Mitotic spindle checkpoint protein BUBR1
- Cell division cycle 20.1, cofactor of APC complex
- Protein TPX2
- Histone H3-like centromeric protein CENH3
- 65-kDa microtubule-associated protein 3
Sequence:
MAIPTETQHQEKEASDASAAAAQKRWTLSDFDIGKPLGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQKRVYLILEYAARGELYKDLQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMVESVEHDASVDIWSLGILCYEFLYGVPPFEAMEHSDTYRRIVQVDLKFPPKPIISASAKDLISQMLVKESSQRLPLHKLLEHPWIVQNADPSGIYRV
Protein: Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (PHS II) (Prostaglandin H2 synthase 2) (Prostaglandin-endoperoxide synthase 2) (Q8SPQ9)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}. Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004386}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004386}. Nucleus outer membrane {ECO:0000256|ARBA:ARBA00004509}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004509}.
Interaction partners:
- Prostaglandin E synthase
- Prostaglandin I2 synthase
- Prostaglandin E synthase 2
- Arachidonate 5-lipoxygenase.
- Prostaglandin-H2 D-isomerase
- Thromboxane A synthase 1
- Hematopoietic prostaglandin D synthase
- Prostaglandin G/H synthase 1
- Phospholipase A2.
- Cytochrome P450 2E1
Sequence:
MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFLTRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNYGYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGTNMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKYQVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRVAGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEALYGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKERSTEL
Protein: Aspartic proteinase 36 (EC 3.4.23.-) (Q4V3D2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Displays aspartic proteolytic activity. Together with A39, contributes to pollen and ovule development, including the apical cell wall constitution of the growing pollen tubes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27872247}; Lipid-anchor, GPI-anchor {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:27872247}. Note=Displays punctate cytosolic localization and colocalizes with the GPI-anchored protein COBL10 at the plasma membrane and in the cytosol (PubMed:27872247). In pollen grains, mainly present at the plasma membrane and in reticular structures in the cytosol (PubMed:27872247). In pollen tubes, exhibits a punctate localization in the cytosol and occurs weakly at the plasma membrane (PubMed:27872247). {ECO:0000269|PubMed:27872247}.
Interaction partners:
Sequence:
MVTTMDPSRISRIVAVVFVLVIQVVSGNFVFNVTHKFAGKEKQLSELKSHDSFRHARMLANIDLPLGGDSRADSIGLYFTKIKLGSPPKEYYVQVDTGSDILWVNCAPCPKCPVKTDLGIPLSLYDSKTSSTSKNVGCEDDFCSFIMQSETCGAKKPCSYHVVYGDGSTSDGDFIKDNITLEQVTGNLRTAPLAQEVVFGCGKNQSGQLGQTDSAVDGIMGFGQSNTSIISQLAAGGSTKRIFSHCLDNMNGGGIFAVGEVESPVVKTTPIVPNQVHYNVILKGMDVDGDPIDLPPSLASTNGDGGTIIDSGTTLAYLPQNLYNSLIEKITAKQQVKLHMVQETFACFSFTSNTDKAFPVVNLHFEDSLKLSVYPHDYLFSLREDMYCFGWQSGGMTTQDGADVILLGDLVLSNKLVVYDLENEVIGWADHNCSSSIKVKDGSGAAYQLGAENLISAASSVMNGTLVTLLSILIWVFHSFTS
Protein: Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) (O14494)
Organism: Homo sapiens (Human)
Function: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P. Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes. May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10962286, ECO:0000269|PubMed:9705349}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:14527693}; Multi-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:17005594}; Multi-pass membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q61469}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6
- Bifunctional epoxide hydrolase 2
- Phosphatidylinositol-glycan-specific phospholipase D
Sequence:
MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPYKEDTIPYALLGGIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP
Protein: Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20) (Q8NEJ0)
Organism: Homo sapiens (Human)
Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12408986}. Nucleus {ECO:0000269|PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VE01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VE01}; Intermembrane side {ECO:0000250|UniProtKB:Q8VE01}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250|UniProtKB:Q8VE01}.
Interaction partners:
Sequence:
MTAPSCAFPVQFRQPSVSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVHMVSSPVGMIPDIYEKEVRLMIPL
Protein: Secondary metabolism regulator LAE1 (Methyltransferase LAE1) (EC 2.1.1.-) (G4MXJ9)
Organism: Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae)
Function: Secondary metabolism regulator that controls the expression of the tenuazonic acid biosynthesis cluster. Methyltransferase that performs automethylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:C8VQG9}.
Interaction partners:
Sequence:
MDKVLHATSLPILPGAIMSKNDAPEVEQLFKENGRLYQVWPRDRYLLPADQTEQDRLDIFSQLFKIILKEKLHTDASRVEENSHVLDLGCGTGLWVILMAHELHPKPSLFIGADVQMTQPDLIPATVRFTPADIEAPWTDEMVQHAPYDLINCRLMKGAIRSWPALYEKIAAHLKPETGVFEQFEIDWQFRCDDGPIPPALKQWSDEVMQAMDQHGMSIRCNREETRSMLLNHGFDDVQEQAIVLPISNWAEDERGREIGRWFNLALNHSTLPMSLAPLFRVMKKTPQYIDELNKAASREVCSQAHTDGVYCMLYIWTARTRPSRRR
Protein: Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1) (P61765)
Organism: Rattus norvegicus (Rat)
Function: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61764}. Membrane; Peripheral membrane protein.
Interaction partners:
- Syntaxin-1A
- Syntaxin-1B
- Syntaxin-3
- Syntaxin-2
- Vesicle-associated membrane protein 2
- Amyloid-beta A4 precursor protein-binding family A member 1
- Complexin-1
- Multifunctional fusion protein
- Syntaxin-3-like
- Regulating synaptic membrane exocytosis protein 1
Sequence:
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS