wanglab/gogpt-training-data huggingface dataset:
Protein: LD26240p (Q7K4R6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPADILQIFQKLALDLLQDLEQPVDRKGCAERSKNLREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAYDDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQLEDLKQKLELLKNQPREQETQGKVVDKSLGEILTDPGPRGRYMVAKEAISKGNVIFSERASCFVPLEQLLICQQCAATLMSAPIPCPNCHQRVVYCSRKCREAHSAIHKFECAAYRKDILRLLGISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLSHSDPITAINLPYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTDPDQNYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPITCTVCHELQHFAWYNEFLGLIGSSADSSKRQALFKAFDDLDKWLVDHHSLKRIMAEELVTACFYEIDGGTSLDEFEYEDLARIIRKQLEGIAAQCGDNSTEYIARMTYLWDIIAQKKCRTDRKELLEMKGKVDYLASEHREVFLNYYNDFIEQ
Protein: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (AtA alpha) (PP2A, subunit A, alpha isoform) (PR-65 A) (Protein ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID 1) (Protein enhancer of ethylene-response 1) (Q38845)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Seems to act as a positive regulator of PP2A catalytic activity. Confers resistance to phosphatase inhibitors such as okadaic acid and cantharidin. Involved during developmental process such as seedling and floral developments, root gravitropism, and stomatal opening regulation. Involved in the regulation of auxin efflux, especially during basipetal (tips to base) auxin transport in roots, and appears to contribute to the perception of auxin efflux inhibitors such as 1-N-naphthylphthalamic acid (NPA) and to semicarbazone I (substituted phenylsemicarbazone of 2-acetylarylcarboxylic acids) (SCB-I). Modulates the magnitude of ethylene response in the hypocotyl and stem, and functions as a general positive transducer of early ABA signaling. The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA or B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22404109}. Nucleus {ECO:0000269|PubMed:22404109}.
Interaction partners:
- Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
- Phytochrome-associated serine/threonine-protein phosphatase 1
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform
- Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform
- Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
Sequence:
MAMVDEPLYPIAVLIDELKNDDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENSDDDDEVLLAMAEELGVFIPFVGGIEFAHVLLPPLESLCTVEETCVREKAVESLCKIGSQMKENDLVESFVPLVKRLAGGEWFAARVSACGIFHVAYQGCTDVLKTELRATYSQLCKDDMPMVRRAAASNLGKFATTVESTFLIAEIMTMFDDLTKDDQDSVRLLAVEGCAALGKLLEPQDCVARILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPDCTRTDLVPAYVRLLRDNEAEVRIAAAGKVTKFCRLLNPELAIQHILPCVKELSSDSSQHVRSALASVIMGMAPILGKDSTIEHLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYVPLLASQLGIGFFDDKLGALCMQWLQDKVYSIREAAANNLKRLAEEFGPEWAMQHLVPQVLDMVNNPHYLHRMMVLRAISLMAPVMGSEITCSKFLPVVVEASKDRVPNIKFNVAKLLQSLIPIVDQSVVDKTIRQCLVDLSEDPDVDVRYFANQALNSIDGSTAAQS
Protein: Blood-group-substance endo-1,4-beta-galactosidase (E-ABase) (EC 3.2.1.102) (Blood group A-and B-cleaving endo-beta-galactosidase) (Q6RUF5)
Organism: Clostridium perfringens
Function: Endo-beta-galactosidase capable of releasing both the blood group A trisaccharide (A-Tri; GalNAcalpha1-->3(Fucalpha1-->2)Gal) and B trisaccharide (B-Tri; Galalpha1-->3(Fucalpha1-->2)Gal) glycotopes from blood group A- and B-containing glycoconjugates, respectively.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MGGVTMKNNLKKYIKYILSVILVFFVGVNGMEVYALEESRDVYLSDLDWLNATHGDDTKSKIVQKNHPFTPGNNNQSTKISLKMEDGSISEFEKGLGTIAGSPSTITYDISGAGVTKFFSYLGIDRSANPINEQYAKVDKIEVVVDGKVIYSTINQFPNGLTYETPAIKVDLNIPENAKRLQLKSYAGEKTWGDEVVYADAKFTAKGDFVNPNDWTPAEKRREISNEKPLLMIPLYANGSKYEKGDYAFWGDDTLVGKWKEVPDDLKPYTVIQLHPDDLPKRDGVAADFYEHMLNEAQSYVNPKTNKNEPIPIVLTVYTAGNVPGYTAAHWLTTEWIEDMYSKYSALQGVFSTENYWVWTDNVESNAAEYLKLSAKYGGYFIWSEQNNGGSIEKAFGSNGKTVFKEAVEKYWENFIFMYKNTPQAEGNDAPTSSYMTGLWLTDYAYQWGGLMDTWKWYETGKWKLFESGNIGKTQGNRQWLTEPEALLGIEAMNIYLNGGCVYNFEHPAYTYGVRNEESPLFSNVIKEFFRYVINNPSPSKNEMRAKTKSLLYGNFTQNGNGNYFVGLNTEMSQSPAYTTGRYGNIPAVPSSIERNKIESRLSGSQIKLIDMNSSELSNITNRKEYFNKLYKEEYNGNIFAQKLDNRWFIYNYKYNENINQKGSFDIANIKSEVTLEPHTYLIMEDNNQSINIKLNNYRTNKDSLWEGAKNADEAKKLPEMSKVDALNWVYDSYIKNTNNGEKRTSVIKLMNIDKAPTITNVNGIEGSYDIPTVKYNSETRSAEITIKNNGNIDFDIVIK
Protein: Anchor, isoform B (M9PFK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ethanol sensitive with low memory, isoform A
Sequence:
MDSSMYYASQRIAASTEANVRVITSTMASSLANGTATPRADDGGVSMNNFYPALVQCFGIIICGYIAGRFKIISNAETKGLGTFVGTFALPSLIFLSLVELNWSAVNWSFLLAMLVSKAVVFFAVLIISLLVARPLNYARGGLMAIFCTQSNDFAIGYPIVMALYKDVHPEYASYLYLMAPISLAILNPVGLVLMEISKIIKNKEDVTRNPPLCPETCPAEQMSKRNRCLGERSILVFNTLIALFFNPLLLMTLLGVAGGFLFPNGLPEMVSSTLRVLGQSFSATALFLLGLKIVGGTGSERKSIGFLLPGVLILVKILVLPLVIRQTVNIMQSGQNFNDTTELSTFGFLYGTFPAAPGAFVIATQYNMEVELVARSMVFCTFISAPLMFISAKMISLTNLKPLDYLHELDAFSFDISVAGAAACCIMLALLIVTKRFKRMPQRITFCLVLSQLMCCIGVILWSKMEHVHRWPLYLQFLLFNIGTYSTRLWTGLLAISLLFLQCRSLCFVLKLWPYMLVFAWGVPAVLSALLIAFDSNVMSGEKHNPSFQYGNAQAAISVFMLVMCFIVTVGCLVLHQRYKKRYEKYMTYSRELSNPESESSDLHSTISTTNLLSHTDQSSIRQSVRTASYSSSSDDEEMIPTAAGLPTSRSNGAASGGAGSGGGGCGSGNGTCCSGGAPVSNSSTTSTVVVDIEDLLNRTRQRASGANNKDLNKIESAPATEEIRNQMCSSSFNCGPSTSRQSCQTIIERYEDQNRRGLEPLEHPSDADEHQTLKHTVLLITLLCSMFVGLAVSIWTLVMEGMSGIYLELSFLDAFLNFGQGLIVLAVFITDIGELLMPVVKLWRKLWYGANVVSLPHWSNVRPETKHICEQFRNHHLENCKKDIAKDRRWRIRVYRRVFYGTEFVSWLIEVGLSKDRMEAVHYARHLVDGRVLRHINNVYHFEDKLLLYNFCSRI
Protein: Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Q70CQ1)
Organism: Homo sapiens (Human)
Function: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
Subcellular location: Nucleus {ECO:0000269|PubMed:31397674, ECO:0000305|PubMed:23824326}. Cytoplasm {ECO:0000269|PubMed:31397674}.
Interaction partners:
- Alkaline phosphatase, placental type
- Histone H2B type 2-E
- HAUS augmin-like complex subunit 2
- Peptidyl-prolyl cis-trans isomerase FKBP5
- Bystin
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALERKKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGGFWVHCNDSKLNVCSVEEVCKTQAYILFYTQRTVQGNARISETHLQAQVQSSNNDEGRPQTFS
Protein: Steroid receptor-associated and regulated protein (Estrogen receptor-related factor) (ER-related factor) (Steroid receptor-regulated protein) (Q8NEQ6)
Organism: Homo sapiens (Human)
Function: May regulate the transcriptional function of androgen and estrogen receptors.
Interaction partners:
Sequence:
MAPSEDPRDWRANLKGTIRETGLETSSGGKLAGHQKTVPTAHLTFVIDCTHGKQLSLAATASPPQAPSPNRGLVTPPMKTYIVFCGENWPHLTRVTPMGGGCLAQARATLPLCRGSVASASFPVSPLCPQEVPEAKGKPVKAAPVRSSTWGTVKDSLKALSSCVCGQAD
Protein: Epsin-1 (O74423)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15659877}. Membrane {ECO:0000255|PROSITE-ProRule:PRU00243, ECO:0000269|PubMed:15659877}; Peripheral membrane protein {ECO:0000269|PubMed:15659877}. Note=Localizes in a punctate pattern. Colocalizes with F-actin.
Interaction partners:
- Probable clathrin heavy chain
- Endocytosis protein end4
- Uncharacterized calcium-binding protein C800.10c
- Clathrin light chain
- ENTH domain-containing protein C794.11c
- Actin cytoskeleton-regulatory complex protein end3
- AP-2 complex subunit alpha
- UBA domain-containing protein 8
- ENTH domain-containing protein C19F8.03c
- Protein BZZ1
Sequence:
MKAAVRSVKNFSKGYTDTQIKVRNATTNDSWGPSGTAMAEIAELTYDQNEMLEVMDIIDRRLNDKGKNWRHVFKSLSLLEYCLHNGSENVVRWAKDNIYIITTLREFVYVDDNGHDQGQNVRTKAKEITSLLEDEHALKEARGDSRERDRDRDRTRSSRFDDDDDDRAPYEESRLSRAPSRASRYDDDDRDHRSRRRSRSRRPGRSRSRRRSRRPSPSAEHNSAEENDPELQRVIEESKRQAEEDAKRRNMANDSEAELQKAIQLSKEEDEARQRHQREREQQEQAFMGNQQNAYQPVDFFGNPVQPQPTGFLQQQPTGFIRPQNTGFVQPQYTGFVQPQHTGFVQPQATGFMQPQRTGFVQPQATGFVQPQATGFVQPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQPQATGFIQPQRTGFVQPQQNGFFNPQPTGYMQPQRTGMMQPQRTGFSQPFESNNPFPVMQPQRTGFGQTPNAPMMAPNHTGYVHPQPTGLQRQTTGYTGNNNPYSRPLQSQSTGILQQQQQQSAPRLEPTKTGSNNPFAQFSNLPSQSTAPATKPMKPVRTGDDRFSNIAQAISTGNPMGTDSFGNIGLTRVPTQHTGSKFTNSAGQTIQAQATGNTHNPFQSQQATGYYKQPMQQQQNMQQPYYNQQNYNYQNQQPMQGMQQQSMQPQVGSLIDL
Protein: Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) (P04694)
Organism: Rattus norvegicus (Rat)
Function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Phenylalanine-4-hydroxylase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- S-adenosylmethionine synthase isoform type-1
- Acireductone dioxygenase-requiring))
- S-adenosylmethionine synthase isoform type-2
- Betaine--homocysteine S-methyltransferase 1
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- Aromatic-L-amino-acid decarboxylase
Sequence:
MDSYVIQTDVDDSLSSVLDVHVNIGGRNSVQGRKKGRKARWDVRPSDMSNKTFNPIRAIVDNMKVQPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGYLSSREEVASYYHCHEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILIPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEPLANLSTNVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILQRTPQEFYHDTLSFLKSNADLCYGALAAIPGLQPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLIAEQAVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK
Protein: Alpha-tubulin 2 (Q8H6M0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
LGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGK
Protein: CaDmium Responsive (Cadmium-inducible lysosomal protein CDR-1) (G5EE89)
Organism: Caenorhabditis elegans
Interaction partners:
- CYtochrome P450 family
- Beta,beta-carotene 9',10'-oxygenase
- CHK domain-containing protein
- Metallothionein-2
- Zinc transporter ttm-1
- Protein quiver
- Zinc transporter 2
- Metallothionein-1
- ShKT domain-containing protein
Sequence:
MLDSCLIITAALFGAAVIYLKNFFTVPSIKPKPDIHKKDYKKDVVYLYQMKRLKNCPNLSPFCMKIEILCRIFKIPYEIITCTSERSRNGLVPFVELNGEHIADSDLIEMRLRSHFKIPSLPTELETQSVALSKFADHHLFFVLIRFKIAVDEFYKTIIEIIGLPTFLNFLLMPLLKAIIGKNVYNKCQGAIGDFELSELDEILHRDLRIVENTLAKKKFLFGEEITAADATVFSQLATVYYPFRNHISDVLEKDFPKLLEYCERVRHEVYPKDFTM
Protein: Protein KNATM (KNOX Arabidopsis thaliana MEINOX protein) (F4HXU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator involved in leaf proximal/distal patterning. May act by sequestering BELL transcription factors.
Subcellular location: [Isoform KNATM-B]: Cytoplasm {ECO:0000269|PubMed:18398054}. Nucleus {ECO:0000269|PubMed:18398054}.
Interaction partners:
- Homeobox protein knotted-1-like 1
- Homeobox protein knotted-1-like 3
- Homeobox protein knotted-1-like 5
- Homeobox protein knotted-1-like 2
- Homeobox protein knotted-1-like 4
- Homeobox protein knotted-1-like 6
- Homeobox protein BEL1 homolog
- BEL1-like homeodomain protein 9
- Homeobox protein knotted-1-like 7
- BEL1-like homeodomain protein 2
Sequence:
MDVKKDENSILENMKQEINHSLKEEAQEEEEILKKRISSHPLYGLLLHSHLNCLKVCSGDFDSPEIMNTADDLALSKLSLHPDSSSEATSSELDQFMVLFFFSPCQNIFTQQKTTFHVLLFFPLQINLTFKYSKFILPRKKQ
Protein: Toxin To7 (PT-alpha* NaTx7.6) (Toxin Tc50) (Toxin To50) (P84688)
Organism: Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Function: Inhibits voltage-gated sodium channels (Nav).
Subcellular location: Secreted {ECO:0000269|PubMed:15025998}.
Interaction partners:
Sequence:
MSIFPIVLALLLIGLEETEALDGYPLSKINNCKIYCPDDDVCKWTCKHRAGATNGKGDCIWYGCYCYDVAPGTKMYPGSSPCYA
Protein: Raptor N-terminal CASPase-like domain-containing protein (Q4GZ02)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- ethanolamine kinase
- Ras-family member, GTP-binding protein, putative
- Small GTPase, putative
- Choline/ethanolamine kinase, putative
- Serine/threonine-protein kinase TOR
- Serine/threonine-protein kinase TOR
- non-specific serine/threonine protein kinase
- PI3K/PI4K catalytic domain-containing protein
- non-specific serine/threonine protein kinase
Sequence:
MNFWTVPSVDDIPPNVSSGTDLEPRTAVEVEAVERRRWLRLVQEAWLRRGRRVPLSEREPPAGGIAAEAAVVPAATTAVVVSININPLLWGEEGDGNQEENSIQALDAPYVFGWRSLGLLPGDSFNILGELGKQLERRYQALSKRSLMVKHCHNTEVSRLHRGLMQCRERAGGRGKVIFHYGGYGVPRPQSGLIYLMEPSGSAVKCRTRTLFEKVGLPLVVVADCPNASELLRNFLRCQSSPKPEHNTGSDAEGDTSFAQGPPDADRPTLRVPHEGTAGVSSFDAGSEETCATSSVLSDFFFLGATFSGELPQHPKLPSDILTSCLMTPLQMALLWFMVENDSLTDIHPLLPFLIPGALDDKKTPLGQLHWATMAIMECIAWSSLPYKTFVHLFREDVVVAPLFRGFLLAERIITALGGEVCVYPPLPHMGNHPQWDSLDCIIGRTFVSLKRAVQPAPPTSLTTLEFREWLDWNVTKWRCEQRSMSLPSLGNRPVTVPDFLEEELRCLMAVAERVTEQSLFHCGGIAWHQCRRPGHIGPHRTGPRKVSIYRGMGEEAAVDPLLACSTGSNDLSGCGCSGGAFMRPFPSVAGLPMLLQGLLVVAHRDEAMKVLCRFIDAGLSAAAACAKVGIFDMALARFWSRSDLQHLLPSMLFVYAKACYADPSLAGLAWAQRSAVTTSCLKALERPFSLPSDPPAGPGLWQCKELGYWLESEGQRVLSSAILSMTSFSFDQDRKYLLESGALNLCSELLRDASVRVPLLQRGSAEVYINQSRGSRVQHHFVATTDAYAARLTTSITSLLALFVALTWKASALEPGAARPINAGTEGALTNGSGGEQKLGLEELASPLKTLHLLSWASSSIIRGAALKAISVTMSSSCTDEATSLRCIHIIVECANVLVAPREGNMSNRIDLVDIVFLSIRWLVRYLSAHMPMETVRASVQCASEKIYRASEAGEGGSNGGGEEDILPGLVSGTRSLICDIYFPKGCPLESCPSKCDNDRAMEVGCPIVFLARLVCWTGAATHDPCPYVSSRAEEALSCLPPLSAGGFFTQPTTPRESGAVEKSTKVPSDAKSRRFLSMLRSSVIRVLKRGMRGTGNRSDGAASRGKAAGVERDRRLSNESGGVADVQTLACDAVLPRRIVSTGSGAAVASFVFTLLGFLDELLLVPMDDDDPRNTFNLRRDFCMREYVHKVRNELRLSAPPAGYSGDSCNLPAVPSPPLPTWSPPVSHVEGVKPLVDEEREPSAMLSPTGSQLPLINLSITSDTSLGASAWSHPVSNVSFEHDGLIGVMAFHMAERHLVTGTSHGTVQVWSWSAEEHLTAMAGRSSTALSAACSLTAATASASTSPATSVGVGSTSVHVKATCRWISDICAPAVTSWVDPVAFARTTTLYNQQQQSGPRKKMTSGIIAKSSHGWVGLPWNIHSAWQCPEEDSPVISEHCATNSIKSVTGLHFVDAAYRTLLCVVGSSGSVQLFMDYAGGTAVKRVTSFATAACGGRCGGGRMPCLSSYHVPATLLHVSGPDGLIDSWDLVCEHKVLEGIGSQQSSFIMPSVITPSSTDDSTVAVGAGSVYLFDLRKPARATCIFPSSAESEDDAAKPPVGGAENSKGTCLHISFPYCYPHVIVTGYGGAKGVVTLWDKRFPRDPLRQVVVAEPVAPASSALRNPVCRMDVQPYHQTLSTVSATADAIFISDVMEESAVNGQARASYTRVKELPGAVAFHPILPICAVATGGPPRIYGRSTTCVYD
Protein: Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] (P22272)
Organism: Mus musculus (Mouse)
Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular location: [Interleukin-6 receptor subunit alpha]: Cell membrane {ECO:0000269|PubMed:27893700}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-6 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:28402851}.
Interaction partners:
- Interleukin-6
- Interleukin-6 receptor subunit beta
- Signal transducer and activator of transcription 3
- Interleukin-11
- Tumor necrosis factor
- Tyrosine-protein kinase JAK2
- Non-receptor tyrosine-protein kinase TYK2
- Ciliary neurotrophic factor
- Interleukin-1 beta
- SHC-transforming protein 1
Sequence:
MLTVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQVPCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPANLVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVIHDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVEDSANHEDQYESSTEATSVLAPVQESSSMSLPTFLVAGGSLAFGLLLCVFIILRLKQKWKSEAEKESKTTSPPPPPYSLGPLKPTFLLVPLLTPHSSGSDNTVNHSCLGVRDAQSPYDNSNRDYLFPR
Protein: DUF21 domain-containing protein At1g47330 (CBS domain-containing protein CBSDUF7) (Q8RY60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSSDIPCCGTTFSLYVVIIIALVAFAGLMAGLTLGLMSLGLVDLEVLIKSGRPQDRINAGKIFPVVKNQHLLLCTLLIGNSMAMEALPIFLDKIVPPWLAILLSVTLILVFGEIMPQAVCTRYGLKVGAIMAPFVRVLLVLFFPISYPISKVLDWMLGKGHGVLLRRAELKTFVNFHGNEAGKGGDLTTDETSIITGALELTEKTAKDAMTPISNAFSLELDTPLNLETLNTIMSVGHSRVPVYFRNPTHIIGLILVKNLLAVDARKEVPLRKMSMRKIPRVSETMPLYDILNEFQKGHSHIAVVYKDLDEQEQSPETSENGIERRKNKKTKDELFKDSCRKPKAQFEVSEKEVFKIETGDAKSGKSENGEEQQGSGKTSLLAAPAKKRHRGCSFCILDIENTPIPDFPTNEEVVGVITMEDVIEELLQEEILDETDEYVNIHNRIRVNMHASPENLPSVITSITQSSSGSTSPNQTSHMATPDSSPTTKPSNSSPTRKPSVSSPTREPSDSSHSMAPKHEESTQTL
Protein: Golgin candidate 3 (AtGC3) (GRIP-related ARF-binding domain-containing Arabidopsis protein 1) (Q84WU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus.
Subcellular location: Golgi apparatus. Endosome.
Interaction partners:
- Golgin candidate 1
- Golgin candidate 2
- Wax ester synthase/diacylglycerol acyltransferase 11
- Golgin
- Golgin candidate 5
Sequence:
MWSSIENMKANLHKIVLDVHEDDEEEDDLHKYGSANGVSNSDRRNSSGFRSVSRYSISNGIESPAHHEIERYKAEIKKLQESESDIKALSVNYAALLREKEDQISRLNQENGSLKQNLTSTSAALKEARTDISRGSNNYAIKGNNDQSPNRLHKSVSHLKSPNHMSNGKGKDTDSFIKEKDLADMLEDRTKSMAAVQATELAKEREKLRDFQLSLQEERKRSESFKEELESMRLDKNKTSMEISKMRSELDAKLLEIKHLQMKLTGQESHAIGPGMEHLKEVNKALEKENNELKLKRSELEAALEESRKLTNSKVFPDATESLTRHPSTLDKEKPESFPGKEEMEQSLQRLEMDLKETQRERDKARQELKRLKQHLLEKETEESEKMDEDSRLIEELRQTNEYQRSQISHLEKSLKQAISNQEDNRLSNDNQIRKLKDTVDDLNQKLTNCLRTIESKNVELLNLQTALGQYYAEIEAKEHFERELAMAKDELMKLSARLKDSDERLESSNKEKEDVTSKLLHAEKVAAEWKNRVTKVEEDNAKVRRVLEQSMTRLNRMSMESDYLVDRRIVIKLLVTYFQKNHNKEVLDLMVRMLGFSEEDKERIGAAKQGGGKGVVRGVLGFPGRFVGGILGGKSAELHANAASDNQSFADLWVDFLLKDAEERERREAEEAAASKAKQDSERTRQEAALHDSEFSTVPLRSSESNQRLSR
Protein: ATP-binding cassette sub-family C member 8 (Q8BNE2)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRADK
Protein: ADAMTS/ADAMTS-like cysteine-rich domain-containing protein (Q3U345)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
VPLILRSQLECGLPGEELCWGDSHEYRVCQLPDCPPGTTPFRDLQCSLYNGHPVLDTQKTYQWVPFHGAPNVCDLNCLAEGHAFYHSFGRELDGTPCTPGTQGLCVAGRCLSAGCDGILGSGTLEDRCGLCGGANDSCLFVQRVFRDAGDCPILTHHQRLRNTVERGVPLTSLAPGSQGSC
Protein: Mini-chromosome maintenance complex-binding protein (Q57V33)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
- DNA helicase
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM2
- DNA helicase
- Minichromosome maintenance
- DNA replication licensing factor MCM6
- DNA primase large subunit
Sequence:
MRRVMDRIYSQPGINAIIREKAAELGSAAAALSYVHRHLREALSSAEVATAVHDVFPIGASQDSVGKLCRCRGMIQEVDPSVALYRASPNNFLGAETTDDAVMLEALQVYVIPVPGNAHFYGIQDQQQTGYQQAQGAATCTEGGGFLPADTSDLGRNSGLDRKRRERTPMGDQTHQGEWNSEDPDVERDPKQSRYEGDKLLGTLPAHSAANVPLHHQLNLPHPPLCWTLHTACVVTVIYGGSAEEEPLRLNDVVDFFGFIDEPSIVEHSCGPYAEVEDFENFDAWHTEQLPPGVLPRMTCLSWQRVYCQPDRPLCHFYFESKRPLVLQHLKNTVCKGDSLLAEYILLHLCARVITQEGGMPVGDLPLRVEGDIVNLDMWSAYMREVAPVGEVLLDLSKLTSSSLRVTSSLDEKSNILRAGVLQLANGTHVTLDSRAVAIASSGVQDAIFSAVHKQVLQLEYPYQKLELPIDLSFLVLSTTKLTDEIGFLQLAVSVRWLPELTTEAAISNDISVDEVRDYFAQVRRLPRRFEREDDISTTQLSDKLLAFSQSEPRWNNHDSFIHNNSFAMAASMMRAYAASVGREVITNESVGFVLALEGQRVARCYDET
Protein: Sushi domain-containing protein 6 (Drug-activated gene overexpressed protein) (Q92537)
Organism: Homo sapiens (Human)
Function: May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MCHGRIAPKSTSVFAVASVGHGVFLPLVILCTLLGDGLASVCPLPPEPENGGYICHPRPCRDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWKPAMEISCRLNEDKDTHTSLGVPTLSIVASTASSVALILLLVVLFVLLQPKLKSFHHSRRDQGVSGDQVSIMVDGVQVALPSYEEAVYGSSGHCVPPADPRVQIVLSEGSGPSGRSVPREQQLPDQGACSSAGGEDEAPGQSGLCEAWGSRASETVMVHQATTSSWVAGSGNRQLAHKETADSENSDIQSLLSLTSEEYTDDIPLLKEA
Protein: LIM homeobox transcription factor 1, beta 2 (LIM homeobox transcription factor 1, beta a) (LIM homeodomain protein) (Q4VJ28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MLDGIKIEDQFRTGAETLGVMLDCAHHQSVCEGCHRPISDRFLLRMNDSSWHEECLQCSVCQQLLTMSCYSRDHKLYCKHDYQQLFATKCSGCLEKISPTELVMRALESVYHLSCFCCCVCERRLCKGDEFVLKEGQLLCKTDYEREKDLASPDLSDSDKSEDEDLDVKPEKGAGGQGKGSDDSKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQEQQNSQRLGQDVMSSRMENLMSSYTPLAPPPPHALVSMESSGYSTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFMSASDAAALQSRVGNPIDRLYSMQSSYFTS