wanglab/gogpt-training-data huggingface dataset:
Protein: SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3 protein expressed in lymphocytes 2) (SH3-lymphocyte protein 2) (SLy2) (P57725)
Organism: Mus musculus (Mouse)
Function: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Subcellular location: Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
Interaction partners:
Sequence:
MLKRKPSNASDKEKHQKPKRSSSFGNFDRFRNNSVSKSDDSIEVHDRELTNGSEEQSKTSSSGGSLGKKVRAISWTMKKKVGKKYIKALSEEKEEESGEEALPYRNSDPMIGTHTEKISLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDSPYSGPFCGRAKVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVILEEEAAPKKIKVPRSRRRENHQTIQEFLERIHLQEYTSTLLLNGYETLDDLKDIKESHLIELNIADPEDRARLLSAAESLLDEETTVEHEKESVPLSSNPDILSASQLEDCPRDSGCYISSENSDNGKEDLESENLSDMVQKIAITESSD
Protein: Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) (Q03113)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15980433}; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane {ECO:0000269|PubMed:15525651}; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Cytoplasm {ECO:0000269|PubMed:15240885}. Note=CDH1 enhances cell membrane localization. {ECO:0000269|PubMed:15240885}.
Interaction partners:
- Rho guanine nucleotide exchange factor 1
- Rho guanine nucleotide exchange factor 11
- Rho guanine nucleotide exchange factor 12
- Lysophosphatidic acid receptor 1
- Sphingosine 1-phosphate receptor 3
- Guanine nucleotide-binding protein subunit alpha-13
- Sphingosine 1-phosphate receptor 2
- Sphingosine 1-phosphate receptor 5
- Sphingosine 1-phosphate receptor 4
- Transforming protein RhoA
Sequence:
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVRFVFHAVKDTILQENLKDIMLQ
Protein: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) (P62137)
Organism: Mus musculus (Mouse)
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62136}. Nucleus {ECO:0000250|UniProtKB:P62136}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P62136}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62136}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000250|UniProtKB:P62136}.
Interaction partners:
- Retinoblastoma-associated protein
- Protein phosphatase 1 regulatory subunit 3C
- Apoptosis-stimulating of p53 protein 2
- Leucine-rich repeat protein SHOC-2
- Protein phosphatase 1 regulatory subunit 7
- Serine/threonine-protein phosphatase 1 regulatory subunit 10
- Neurabin-2
- Protein phosphatase 1 regulatory subunit 3B
- Protein phosphatase 1 regulatory subunit 3A
- Nuclear inhibitor of protein phosphatase 1
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIRYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
Protein: Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIIA) (Cytochrome c oxidase polypeptide VIIc) (P00430)
Organism: Bos taurus (Bovine)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}; Single-pass membrane protein {ECO:0000269|PubMed:27605664, ECO:0000269|PubMed:31533957}.
Interaction partners:
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 6A2, mitochondrial
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 7A1, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome b-c1 complex subunit 9
Sequence:
MLGQSIRRFTTSVVRRSHYEEGPGKNIPFSVENKWRLLAMMTLFFGSGFAAPFFIVRHQLLKK
Protein: Gamma-secretase subunit pen-2 (Presenilin enhancer protein 2) (Q86BE9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Presenilin homolog
- Nicastrin
- Gamma-secretase subunit Aph-1
- Neurogenic locus Notch protein
- ADAM10 endopeptidase
- ADAM10 endopeptidase
Sequence:
MDISKAPNPRKLELCRKYFFAGFAFLPFVWAINVCWFFTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQTNRTAWGATADYMSFIIPLGSA
Protein: Ras-related protein Rab-21 (Q9UL25)
Organism: Homo sapiens (Human)
Function: Small GTPase involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10887961}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:25648148}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10887961}. Cleavage furrow {ECO:0000269|PubMed:18804435}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P35282}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- Ankyrin repeat domain-containing protein 27
- Myotubularin-related protein 13
- Integrin beta-1
- Rab GDP dissociation inhibitor alpha
- Rab GDP dissociation inhibitor beta
- Myotubularin-related protein 5
Sequence:
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQIIDDEPQAQTSGGGCCSSG
Protein: EMBRYO DEFECTIVE 3147 (Putative malonyl-CoA) (Q8RU07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Beta-ketoacyl-[acyl-carrier-protein] synthase III, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic
- Biotin carboxylase, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- NADPH-dependent aldehyde reductase 2, chloroplastic
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic
Sequence:
MRSLLHRTILLTSPSHSLIRRTSLSAMATTASSSLLLPSISLNNLSSSKNASFGFAAKNLSRSRISMSVSAGSQSTTVHDSLFADYKPTSAFLFPGQGAQAVGMGKESQSVGAAGELYKKANDILGYDLLDICVNGPKEKLDSTVISQPAIYVTSLAAVELLRVREGGEQIINSVDVTCGLSLGEYTALAFAGAFSFEDGLKLVKLRGEAMQAAADAAKSAMVSIIGLDSEKVQQLCDAANQEVDEADKVQIANYLCPGNYAVSGGLKGIEVVEAKAKSFKARMTVRLAVAGAFHTSFMEPAVSRLEAALAATEIRSPRIPVISNVDAQPHADPDTIKKILARQVTSPVQWETTVKTLLSKGLKSSYELGPGKVIAGIFKRVDKSASFENISA
Protein: Uridine permease (P38196)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity transport of uridine.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- GPI ethanolamine phosphate transferase 2
- Purine-cytosine permease FCY2
- Uncharacterized protein YGR130C
Sequence:
MPVSDSGFDNSSKTMKDDTIPTEDYEEITKESEMGDATKITSKIDANVIEKKDTDSENNITIAQDDEKVSWLQRVVEFFEVKNDSTDLADHKPENPIRTFKDLQESLRSTYLYNTDLRPVEAKRRTWTWKQYIFFWISGSFNVNTWQISATGLQLGLNWWQTWICIWVGYTFVAFFLILGSKVGNNYHISFPISSRVSFGIYFSIWIVINRVVMACVWNSTLAYIGSQCVQLMLKAIFGTNLNTRIKDTIKNPNLTNFEFMCFMVFWVACLPFLWFPPDKLRHIFALKSAITPFAAFGFLIWTLCKAKGHLALGSLNDNGGAISKTVLAWSVIRAIMSALDNFSTLILNAPDFTRFGKTYKSSVYSQLIALPVCYAIISLIGILSVSAAYTLYGVNYWSPLDILNRYLDNYTSGNRAGVFLISFIFAFDQLGANLSGNSIPAGTDLTALLPKFINIRRGSYICALISLAICPWDLLSSSSKFTTALAAYAVFLSAIAGVISADYFIVRKGYVNIFHCYTDKPGSYYMYNKYGTNWRAVVAYIFGIAPNFAGFLGSVGVSVPIGAMKVYYLNYFVGYLLAALSYCILVYFYPIKGIPGDAKITDRKWLEEWVEVEEFGTEREAFEEYGGVSTGYEKIRYI
Protein: Cysteine desulfhydrase (EC 4.4.1.1) (Q4Q511)
Organism: Leishmania major
Interaction partners:
- cystathionine beta-synthase
- cysteine synthase
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- Methionine synthase
- Putative homocysteine S-methyltransferase
- Cysteine conjugate beta-lyase,aminotransferase-like protein
- Mercaptopyruvate sulfurtransferase
- Adenosylhomocysteinase
- Transaminase A
- Aspartate aminotransferase
Sequence:
MPNQSFEECSVETKLGHVGRNPDEQWGFINCPIYRGSTVLYKSINDALKLRSVYWYGTAGNPTVTNLQNAWTALTGGAGSVVVSSGMQAIAYALLATANSGDNILVADAVYLPTRNLCDHFLVTKGITTTYYDPCITADELRELLHQKPNTTVIFMESPGSQTFEIQDVPMICAVAREFNVTTIIDNTWATPIFFDALGIGCDISVEAGTKYVGGHSDLLLGLISANEKWYPKLRGFMSLLQSVPSNEDCYLGLRGLRTMYIRLKEAEQRGLEMARFMESRKEVLKVLHPAFPSCRGHEIWRRDFTGSSGLFSIVLRPEYALQDVERMIDGYKLFSIGFSWGGFESLVMCFDCTKFRTATTFAPGGILLRFQIGLEGLEDLKQDLCQGFDKLHAESMGC
Protein: Secreted protein CSS3 (Condition specific secretion protein 3) (Q08300)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000305|PubMed:11935221}. Secreted {ECO:0000269|PubMed:26928762}.
Interaction partners:
- Uncharacterized protein YML079W
- Secreted protein CSS2
Sequence:
MVPLFGLFCIFSQLYSLCSAYVDITSGYQVFFNLPTNMTNNQICWLFQASYYDIYSDKSGRTLRTGRFEPGDQQSLIYRDTLVELEAITDSYEYSNLDLSTYNGPEPYNSETDYCTDIMDLVMRVYDEEGHYVHPVANNSTNACAHPTPPTLNNLLISNYSDGRNYKESSI
Protein: Glutathione S transferase D11, isoform A (EC 1.11.1.9, EC 2.5.1.18) (RE72392p) (Q8SXQ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSPPVLYYLPPSPPCRSILLLAKMLDIDFELKIVNILEGEQLKPDFVAMNPQHCVPTMNDEGLVLWESRAILSYLVAAYGKSDQLYPTDIRVRALVDQRLQFDLGTLYMRLTDYYFPTMFIGAPLDEGKRAKLAEAVGWLNTILEGRQFSAADHFTIADLTLLVTVSQLEAFEFELRPYKHIRQWLDRCKDHMAPFDYEELNANKANMLADMFKAKMNQSAG
Protein: ABI family member 3 binding protein (Target of Nesh-SH3 variant 1) (Q59IW9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLSSLGCLLLCGSIALALGNAQKLPKGKKPSLKVHINTTSDSILLKFLRPNANVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVVDAEPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPSDRFYTIRYREKDKEKKWIFQLCPATETIVENLKPNTVYEFGVKDNIEGGIWSKIFNHKTIVGSKNKVNGKIQSTYDQVHSVPVPRKLIPLTIIKQVIQNVTHRASTKSPDKTPFGGTILVHLIIPGLNESTVKLPTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALVLSEKTSETARSVLIPEFELPLSTLAPKRFPEFPEAKTAFPLEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSDETEIEIHTATRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW
Protein: Cilia- and flagella-associated protein 52 (A0A0A1CTQ1)
Organism: Schmidtea mediterranea (Freshwater planarian flatworm)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
IYGLGCTVVIEDLNTKNQCFLQGHTNNVVCITVSNSGKYIASGQITHMGYKADIMLWDYVTKQCVSTFSLHKVKVQSLAFSPNEKYLASLGGQDDGCVVIWSLTKMEPICGSPAQHKSAGITECLVYSNTNDDVFVTAGENTLRVWELDVENRKIRPTECSLGAIKRSIKCITISKDDSVFFCGTSSGDILGVNMKSCLLSCIGPEKETFSLGVLSIIRLINGDLIVGAGDGTICQVKVVEKKEGNKIMPKIVKTSNSCMLVGGVSSITLRGQGHQFYAGTEKSHIYRFSLGDFKSELINTAHYSAVNDIVYPNNCPKLFVTCSFQDVRVFHSDSQKELLRINIPNMTCYTCDIFKDGTAIITGWDDSKIRAFYPETGALMYTINDAHKKGVTAIAATSDCRKVVSGGGEGQVRVWRIEECKVSQANTIPHSHGNRKKSNVKSVVYVAHMETAMKEHANAVSCIRMNKDDTQCVSSSADGTCIIWCLIKYTRKQIMFANTLFRCVC
Protein: Protein E6 (Q2VJD5)
Organism: Human papillomavirus type 68a
Subcellular location: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123}.
Interaction partners:
Sequence:
MALFHNPEERPYKLPDLCRTLDTTLHDVTIDCVYCRRQLQRTEVYEFAFSDLCVVYRDGVPFAACQSCIKFYAKIRELRYYSESVYATTLETITNTKLYNLLIRCMSCLKPLCPAEKLRHLTTKRRLHKIAGNFTGQCRHCWTSKREDRRRIRQETQV
Protein: Large ribosomal subunit protein uL16m (39S ribosomal protein L16, mitochondrial) (L16mt) (MRP-L16) (Q9NX20)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein uL13m
Sequence:
MWRLLARASAPLLRVPLSDSWALLPASAGVKTLLPVPSFEDVSIPEKPKLRFIERAPLVPKVRREPKNLSDIRGPSTEATEFTEGNFAILALGGGYLHWGHFEMMRLTINRSMDPKNMFAIWRVPAPFKPITRKSVGHRMGGGKGAIDHYVTPVKAGRLVVEMGGRCEFEEVQGFLDQVAHKLPFAAKAVSRGTLEKMRKDQEERERNNQNPWTFERIATANMLGIRKVLSPYDLTHKGKYWGKFYMPKRV
Protein: Purine-rich binding protein-alpha, isoform G (RE62347p) (F3YDK4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMASQDQGSSSRNDFDSSAKGGSGVEQELATKMLQIQSKRFYLDVKQNRRGRFIKVAEIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTDNLPEDGKLKSEMMIKDYRRYYLDLKENARGRFLRVSQTITRGGPRSQIALPAQGMIEFRDALTDLLEEFGANDGGFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSITIPEKCWIRFRDIFNDYCEKMKKSSDSITAEINLPTSSNSLK
Protein: Carboxylesterase (EC 3.1.1.1) (Q976W8)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Interaction partners:
- NADH-quinone oxidoreductase subunit I
- S-methyl-5'-thioadenosine phosphorylase
- Rieske iron-sulfur protein
- Rieske iron-sulfur protein II
- Rieske iron-sulfur protein I
- Arsenite oxidase small subunit
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit A
- NADH-quinone oxidoreductase subunit B
Sequence:
MIDPKIKKLLESTIQLPIGKASVEEIRSLFKQFSSLTPREEVGKIEDITIPGSETNIKARVYYPKTQGPYGVLVYYHGGGFVLGDIESYDPLCRAITNSCQCVTISVDYRLAPENKFPAAVVDSFDALKWVYNNSEKFNGKYGIAVGGDSAGGNLAAVTAILSKKENIKLKYQVLIYPAVSFDLITKSLYDNGEGFFLTREHIDWFGQQYLRSFADLLDFRFSPILADLNDLPPALIITAEHDPLRDQGEAYANKLLQSGVQVTSVRFNNVIHGFVSFFPFIEQGRDAIGLIGYVLRKVFYGK
Protein: Ethylene-responsive transcription factor ABR1 (Protein ABA REPRESSOR 1) (Q9FGF8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negative regulator of the abscisic acid (ABA) signaling pathway involved in seed germination and in responses to stress conditions. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 3
- Zinc finger transcription factor YY1
Sequence:
MCVLKVANQEDNVGKKAESIRDDDHRTLSEIDQWLYLFAAEDDHHRHSFPTQQPPPSSSSSSLISGFSREMEMSAIVSALTHVVAGNVPQHQQGGGEGSGEGTSNSSSSSGQKRRREVEEGGAKAVKAANTLTVDQYFSGGSSTSKVREASSNMSGPGPTYEYTTTATASSETSSFSGDQPRRRYRGVRQRPWGKWAAEIRDPFKAARVWLGTFDNAESAARAYDEAALRFRGNKAKLNFPENVKLVRPASTEAQPVHQTAAQRPTQSRNSGSTTTLLPIRPASNQSVHSQPLMQSYNLSYSEMARQQQQFQQHHQQSLDLYDQMSFPLRFGHTGGSMMQSTSSSSSHSRPLFSPAAVQPPPESASETGYLQDIQWPSDKTSNNYNNSPSS
Protein: tRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (Q72DU3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Specifically methylates guanosine-37 in various tRNAs.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Large ribosomal subunit protein bL19
- Ribosome maturation factor RimM
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS2
- Bifunctional enzyme IspD/IspF
- Large ribosomal subunit protein uL2
- Transcription termination/antitermination protein NusA
- Elongation factor Ts
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein bS6
Sequence:
MRCTILTLFPEFFDSPLDAGLMGKARESGLIDVALVNPRAYTTDRHSTVDDRPYGGGPGMVMRVEPWEKALQGIEEPGRILMMAPKGRPFTQAMARELAQEESLTILCGRYEGFDARLEEIYPIEAVSMGDFVLNGGETAALAVLEAVSRLVPGFMGKEESGTEESFSAGLLEYPHYTRPEDYAGHVVPEVLRSGDHGRIAAWRKECSLRLTLSQRPDILPEAQLDEADMDFLRGLSRNRPGRNLYCALVHYPVVLKEKNSGATSLTNLDIHDIGRSSCTYGLGGFYVTTPLEDQRRLLDTLLRHWTLGPGSRSNPDRAEALGRIKGVDDVRAAIEDIARRTGQVPYVVGTSAKGAGNATPASVRAMLEERPVLLVFGTGHGLAPEVLEGCDAILRPLRWMDGYNHLSVRAAAAIIMDRLLGDCY
Protein: NADP-dependent malic enzyme 3 (AtNADP-ME3) (NADP-malic enzyme 3) (EC 1.1.1.40) (Q9XGZ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19725876}.
Interaction partners:
- Malate synthase
- Fumarate hydratase 1, mitochondrial
- Fumarate hydratase 2
- D-lactate dehydrogenase [cytochrome], mitochondrial
- Malate dehydrogenase, chloroplastic
- L-lactate dehydrogenase
- Acetolactate synthase, chloroplastic
- Pyruvate, phosphate dikinase 1, chloroplastic
- Alanine aminotransferase 2, mitochondrial
- Glutamate--glyoxylate aminotransferase 2
Sequence:
MGTNQTQISDEYVTGNSSGVGGGISDVYGEDSATLDQLVTPWVTSVASGYTLMRDPRYNKGLAFTDKERDAHYITGLLPPVVLSQDVQERKVMHNLRQYTVPLQRYMALMDLQERNERLFYKLLIDNVEELLPVVYTPTVGEACQKYGSIYRRPQGLYISLKEKGKILEVLKNWPQRGIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGIRPSACLPITIDVGTNNEKLLNNEFYIGLKQKRANGEEYAEFLQEFMCAVKQNYGEKVLVQFEDFANHHAFELLSKYCSSHLVFNDDIQGTASVVLAGLIAAQKVLGKSLADHTFLFLGAGEAGTGIAELIALKISKETGKPIDETRKKIWLVDSKGLIVSERKESLQHFKQPWAHDHKPVKELLAAVNAIKPTVLIGTSGVGKTFTKEVVEAMATLNEKPLILALSNPTSQAECTAEEAYTWTKGRAIFASGSPFDPVQYDGKKFTPGQANNCYIFPGLGLGLIMSGAIRVRDDMLLAASEALASQVTEENFANGLIYPPFANIRKISANIAASVGAKTYELGLASNLPRPKDLVKMAESCMYSPVYRNFR