Protein: Receptor-type guanylate cyclase daf-11 (EC 4.6.1.2) (Abnormal dauer formation protein 11) (Q8I4N4)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response to NO-producing organisms like P.aeruginosa. In ASI and ASJ sensory neurons, controls dauer formation and behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family. Required for the chemotaxis responses to non-volatile and volatile attractants mediated by the sensory neurons ASE and AWC respectively. Required in ASJ neurons for phototransduction downstream of G protein coupled-photoreceptor lite-1. Plays a role in the development of ASJ sensory neuron axons during late larval stages and in the maintenance of normal axon morphology in adults. Required to maintain the expression of putative olfactory receptor str-2 in one of the two AWC neurons in adults. Regulates, via the production of cGMP, lifespan (in some environmental conditions), sensitivity to oxidative stress and entry into quiescence triggered by satiety. In AWB and AWC sensory neurons, mediates the recognition of food odors which subsequently allows for the detection of preferred food sources.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:10790386}. Cell projection, cilium {ECO:0000269|PubMed:10790386}. Perikaryon {ECO:0000269|PubMed:10790386}. Note=Expressed preferentially in ciliated endings of sensory neurons (PubMed:10790386). Cilium localization is regulated by daf-25 (PubMed:21124868). {ECO:0000269|PubMed:10790386, ECO:0000269|PubMed:21124868}.
Interaction partners:
- Guanine nucleotide-binding protein alpha-3 subunit
- Cyclic nucleotide-binding domain-containing protein
- Cyclic nucleotide-gated channel
- Dauer larva development regulatory growth factor daf-7
- Guanine nucleotide-binding protein alpha-17 subunit
- Guanine nucleotide-binding protein alpha-2 subunit
- cGMP-dependent protein kinase egl-4
- Uncharacterized protein
- Dwarfin sma.
- Probable 3',5'-cyclic phosphodiesterase pde-2
Sequence:
MGPTCSSNFLRFANLTAEMQSLEINILKGYPYEHPTMIDMVTRSPQNLAQNLVSLLRGFEWGQVGAVLCEECYEGDELASEIYFSTIEDIFENNNIALKETVRIGKRENSVNISDAITIFEPSARVILLFLGNKLNDYTEFMTAMSMNNYTTEEYTPVIVISKNSLELTFPWKENDAIAELFDKAIIVYNNCYDKSKISSFLSSYSFSTIEETIISLQMYEGYHLLGYYLYTAITNTTLFNYVQPEKAISSMSIPGPFGEIFINSNGQRIAGYDVLVVDKSLNSNNFIMPLGTISTDKKCPDQACLNFVLNSTSSFEPLKDVPLCGFHGEICDQTGVIIAIAVIMGVLLMFIIILTTIRKCCNGSKGRSISNPWVIPFQDVRFIDLTNTEGSQHMSIQSLQRNMEEKQRLQSLARTKHIATVDQVYVLADKYVMRDKLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQIFTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQFGKKCDMYSFGVILHEIILKKKFVEQLFDSPREEDDSVLIDDENDAIASRFPLPIIIPEGIEMHNDLIKMLENCFGSVRPDIALARKIIDTVLKMSGSLVDLMIKNLTAYTQGLNETVKNRTAELEKEQEKGDQLLMELLPKSVANDLKNGIAVDPKVYENATILYSDIVGFTSLCSQSQPMEVVTLLSGMYQRFDLIISQQGGYKMETIGDAYCVAAGLPVVMEKDHVKSICMIALLQRDCLHHFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQMTLASQQLLEENFPQFVCSNRGGRTIEGIGRILTYWLEGVNAGEQVKVVEFQNDLNDELSRIMKKDGELLAAATALKPKDKMTLAKEKVIAERKNEEERLQRQQTLQEALEEHEEEIEMNEVLVDEDEGEGKPKEVDLTSIVSTQMEELEDEPAGRTIGHGRLDSQASTIPDN