wanglab/gogpt-training-data huggingface dataset:
Protein: ATPase 8, plasma membrane-type (EC 7.1.2.1) (Proton pump 8) (Q9M2A0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Soluble inorganic pyrophosphatase 3
- Soluble inorganic pyrophosphatase 4
- Soluble inorganic pyrophosphatase 5
- Soluble inorganic pyrophosphatase 1
- Soluble inorganic pyrophosphatase 2
- Soluble inorganic pyrophosphatase 6, chloroplastic
- Alpha carbonic anhydrase 5
Sequence:
MATEFSWDEIKKENVDLERIPVEEVFEQLKCSKEGLSSDEGAKRLEIFGANKLEEKSENKFLKFLGFMWNPLSWVMESAAIMAIVLANGGGKAPDWQDFIGIMVLLIINSTISFIEENNAGNAAAALMANLAPKTKVLRDGKWGEQEASILVPGDLISIKLGDIVPADARLLEGDPLKIDQSALTGESLPTTKHPGDEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNNVGHFQKVLTSIGNFCICSIGLGMLIEILIMYPIQHRTYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKSLIEVFPKNMDSDSVVLMAARASRIENQDAIDASIVGMLGDPKEARAGITEVHFLPFNPVDKRTAITYIDESGDWHRSSKGAPEQIIELCNLQGETKRKAHEVIDGFAERGLRSLGVAQQTVPEKTKESDGSPWEFVGLLPLFDPPRHDSAETIRRALELGVNVKMITGDQLAIGIETGRRLGMGTNMYPSTSLLGNSKDESLVGIPIDELIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLVALIWRFDFAPFMVLIIAILNDGTIMTISKDRVKPSPVPDSWKLNEIFATGVVLGTYMALTTVLFFWLAHDTDFFSKTFGVRSIQGNEEELMAALYLQVSIISQALIFVTRSRSWSFVERPGFLLLIAFVIAQLVATLIAVYANWGFARIVGCGWGWAGGIWVYSIITYIPLDILKFIIRYALTGKAWDNMINQKTAFTTKKDYGKGEREAQWALAQRTLHGLPPPEAMFNDNKNELSEIAEQAKRRAEVARLRELHTLKGHVESVVKLKGLDIDTIQQHYTV
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) (P91929)
Organism: Drosophila melanogaster (Fruit fly)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:23509070, ECO:0000269|PubMed:28683319}. Cytoplasm {ECO:0000269|PubMed:23509070}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 23 kDa subunit
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 10
- Complex I-49kD
Sequence:
MTAVFRVGLVRLVSRATQSPNLLQAQTNALPAAFQQRCSISGKTMRGGPRVPKAAPYPYKTKKYSVFNAIFDKTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEYYPAVDLDLIYINSYGYDMRKLDPQLPPSCRSYDVRNFCLDPSHDLAAQFQIRMYMLRYSQYIDALQHVLSTGQGVVLERSPYSDFVFMEAMFRQGYLSRGARSVYNELRQNTIGELLKPHLVIYLDLPVDAVKKQIKARNVDYEVQSKVFSDAYLSDLEQLYKQQYLKDISTHAELLIYDWTAGGETEVVVEDIERIDFNQFEADIHNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELVRSADDGKVWRDVWFNAPGMKYRPGYNADMGDEGLLTKTKIGINQGI
Protein: Immunoglobulin superfamily member 2 (IgSF2) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101) (A8E0Y8)
Organism: Mus musculus (Mouse)
Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MACILCVASLFLSLTKFSIGQREVKIQEGPLYRAEGYPVSIRCTVSGHQGPSTQDFRWSIYLPSAPTKEVQIISTKDAGFSYAVYAQRVQSKEIYIERLQGDSVLLHISKLQMKDAGEYECHTPNTDGKYFGSYSAKTNLTVVPDTLSATMPSQTLSKKEGEPLELTCETTKATVQHTHLSLTWYLMQEGGGSQATEIVSLSKDFVLTPGSSYADRFVAGDVRLDKLGATSFRLSVGKLQPSDQGQVFCEATEWIQDPDETWTLITRKQTDQTALRIQPAARDFTVSITASSSPDEGKPLELVCLAVGRDGNPQLQGVWFLNGKEIAQTDAGGVLDLKRDYRDRASQGQLQVSKLSAQTFSLKIFSVGPEDVGTYSCEVAEVARTQMGSWQVLQRKQSPGYRVQLREPAARSVTVSAEQRTVWEGETLTLLCKAAGDVSALSVSWWLTPQDQSTPVFVAGMGQDGTVQLGVSSPGPAHRGNRRLEKVDWATFRLEIASAMVTDSGTYECRVSERLQNQAKGLQSTQKISVTVKSLKSSLRVNLMSRQPQVMLAHTFHLSCVVRANYSDLKLPFSVTWQFQPAGSGAFHRLIRIAHNGTVEWGDVLSQIHRKTKVSQSFFRSQLQIYDAAMEETGVYRCTVEVYDRDSICTSGPARVSATSNLLMITVTFPESKLSVNSSSQVQELSISSSTQIECAILSRSAGNLPLSIIWYFSSVSANASYLKILEMDQSSVVKYGDEFQTPRSKQKFYSEKVSQDLFLLNILSVEDSDQGHYHCAVEEWLLSTNDTWQKLERKTSGLTELKLRPTGSQVHVSKVNWTGNATEYGEAGFSCSLDGSGSTASLYSVTWYRGRGTATATAAAVANATATITAPAGSQMLVHLQYDGLLQYGREGSRRLQHCYRSSPTDFVLKLHRVEMEDAGIYWCRVTEWQQHGHPGKWINQASGESQRMVLRVLRSEPTVSSLICSSGPLLHFLIVCPFVMLLLLATSFLCLYRKARKLSQLSLSAKKEKALWVGMRKTSLQKEAGEESGHY
Protein: PHD finger protein ALFIN-LIKE 1 (Protein AL1) (Q9FFF5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:19154204}.
Interaction partners:
- Serine/threonine-protein kinase GRIK1
- Protein TRAUCO
- PHD finger protein ING1
- Late embryogenesis abundant
- Protein RBL
- Multiple organellar RNA editing factor 1, mitochondrial
- Serine/threonine-protein kinase GRIK2
- Expressed protein
- Rho GTPase-activating gacO-like protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
Sequence:
MAAESSNPRTVEEIFKDFSGRRSGFLRALSVDVDKFYSLCDPEMENLCLYGHPNGTWEVNLPAEEVPPELPEPALGINFARDGMQRKDWLSLVAVHSDCWLLSVSSYFGARLNRNERKRLFSLINDLPTLFEVVTGRKPIKDGKPSMDLGSKSRNGVKRSIEGQTKSTPKLMEESYEDEDDEHGDTLCGSCGGNYTNDEFWICCDVCERWYHGKCVKITPAKAESIKQYKCPSCCTKKGRQ
Protein: Bis(5'-nucleosyl)-tetraphosphatase [symmetrical] (EC 3.6.1.41) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase) (Diadenosine tetraphosphatase) (P05637)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
Interaction partners:
- Protein ApaG
- Ribosomal RNA small subunit methyltransferase A
- Chaperone SurA
- Putative ankyrin repeat protein YahD
- 4-hydroxythreonine-4-phosphate dehydrogenase
- RNA pyrophosphohydrolase
- Dihydrofolate reductase
- LPS-assembly protein LptD
Sequence:
MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGTLTCLRWEDKQYFVQPSNRHKDLGEAAAS
Protein: MHC class II-associated invariant chain (Q9BD54)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
ATMAEEQRDLISSDGSSGVLPIGNSERSSLGRRTALSALSILVALLIAGQAVTIYYVYQQSGQISKLTKTSQTLKLESLQRKMPIGTQPANKMSMSTMNMPMAMKVLPLAPSVGDMPVEAMKPRSNKTEDQIRHLLLKSDPRKTFPDLKDDMLGNLKRLKKTMSAMDWQDFETWMHKWLLFEMAKGPKMEEQNTIPAEKVQTKCQAEASFGGVHPGRFRPECDENGDYLPKQCYASTGYCWCCYKNGTRIEGTATRGQLDCSAPAPTQPPSTEPEEVIFSGVDMVKAK
Protein: Intraflagellar transport protein 46 homolog (Q9NQC8)
Organism: Homo sapiens (Human)
Function: Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. {ECO:0000250}.
Interaction partners:
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 56
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 70B
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 25 homolog
Sequence:
MADNSSDECEEENNKEKKKTSQLTPQRGFSENEDDDDDDDDSSETDSDSDDDDEEHGAPLEGAYDPADYEHLPVSAEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDNLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTAEIDCSLAEYIDMICAILDIPVYKSRIQSLHLLFSLYSEFKNSQHFKALAEGKKAFTPSSNSTSQAGDMETLTFS
Protein: 5-methylcytosine-modifying enzyme 1 (5mC-modifying enzyme 1) (EC 1.14.99.-) (Ten-eleven translocation 1 gene protein homolog) (CrTET1) (A0A2K3D5Z7)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Dioxygenase that catalyzes DNA modification by mediating the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-glyceryl-methylcytosine (5gmC). Catalyzes the conjugation of a glyceryl moiety from L-ascorbate (vitamin C) to the methyl group of 5mC through a carbon-carbon bond. 5gmC DNA modification may be required during photosynthesis as an epigenetic mark that couteracts DNA methylation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
Sequence:
MSVALASEYQLVQNAQLPQRWSQSARKSLAILEATARKEATAQMEAAGGSFCGQFPVDPAFKVLSLEYSAPNPDIARAIRRVDSVPNPPLPSHVVAIQSTAVDADLSLAMGVSLTPGRHTSYLVDARALQQSNSAAVAARKADGDKWGPACDEMFRGCRCVTGQEVVFYTAVKEPAGEVEGGEGSLFKPSFDGPAFRPSWGELSGKATGVVACVLQVPIGKETDIICAEYDNLVSKGQFATVDRFGGDHTVNMTGNALIQNDGKAISKGYAVAHRARVTSNVYGKANDVSLQRLAETVWSVVEKRLSFMPAYRDLVITEQGKPFMLGATATNIISLTENQGVMLHLDTDDGVWTIILWFHRHSGIIAGGEFVLPSLGISFQPLDFTIVVFAANTIVHGTRPLQTTGKIIRWGSSHFLRFKDVNALAQLGAAYGVDELDAKQRDQLEEVDAANSKDGVGAARRVASCMAAERKAAIEAQKAACVRGVVMNPCTGRMPSLLFWQVWRKPPALAVRANAVAGKKRAAADVDFCGA
Protein: Anoctamin (Q9VDV4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
Sequence:
MLNLGSAKVGALEEATSPPPFSKDESFQLLERSPHNPAISPTTTVPLEPPFTTPLAPFDMELMKRHNLHERLTGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKEIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASIQEPNAKFINIEKLLTENLTQIEMDAIIHGENPITGISGADCLDEVHKKLSD
Protein: Phosducin-like protein (PHLP) (Q63737)
Organism: Rattus norvegicus (Rat)
Function: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular location: Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit gamma
Sequence:
MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPASSSTPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKECGMMDKNLDDEEFLQQYRKQRMDEMRQQLHKGPQFKQVLEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLAAEYPTVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
Protein: Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (B4E2H2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTLEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLRQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAIKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAPLNMGTANSAQPRSLRSWRTWIRILDCKDTEDADLTPATYPKTSLVCGQQQKCLQDRPK
Protein: Ornithine decarboxylase (ODC) (EC 4.1.1.17) (P41931)
Organism: Caenorhabditis elegans
Function: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Interaction partners:
- PABS domain-containing protein
- Ornithine decarboxylase antizyme
- S-adenosylmethionine decarboxylase proenzyme
- Probable ornithine aminotransferase, mitochondrial
- Arginase
- Deoxyhypusine hydroxylase
- Saccharopine dehydrogenase
- Multifunctional protein pyr-1
- Probable delta-1-pyrroline-5-carboxylate synthase
- 26S protease regulatory subunit 6A
Sequence:
MISQFEIIGDNKIGVLPKQVDQLQMCRDIAASKDLQENDSSFMLVDLDKIIERFQLWKRELPMIEPFYAVKCNTDLVLIRILASLGCGFDCASKDEIDIVMGTGVSAERIIYANPCKTRSFIAHAMDRDVKMMTFDNPEELLKIAKLHPNAEMILRIAVSDPTATCPLNLKFGADPIIAAPQLLKTASEEGINVVGISFHVGSGCNDASAYRNALQHAKNLCEIGEGLGFKMDIIDMGGGFPGAEHHNPFEKIAETIRDALDEFFPDTNKRLIAEPGRFFAAGPFSLVANIIHATEVPASKITKDPKDCADHGYMYYINDGVYGSFNCILFDHAHPIGSPLFDTDRNEKFMSTIWGPTCDSLDLVEDKKLMPKMNVGEWLYYPDMGAYTLAAATTFNGFSKPVPMYVMSEEMWESIRDSTHV
Protein: Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha) (A1A547)
Organism: Mus musculus (Mouse)
Function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Peptidoglycan recognition protein 4
Sequence:
MLVSWDHPKMLPRLLGFLALSLLACGNPTIVSRKEWGASSLTCRVPLSLPVPYLIIEQVTRMQCQDQITCSQVVRVLQSQYVHNKGWCDIAFNFLVGDDGKVYEGVGWYVQGLHTQGYNNVSLGIAFFGSKIGSPSPAALSATEDLIFFAIQNGYLSPKYIQPFLLKEETCLVPQHSEIPKKACPNITPRSAWEARETHCPQMNLPAKFVIIIHTAGKSCNESADCLVRVRDTQSFHIDNQDFCDIAYHFLVGQDGEVYEGVGWNIEGSHTYGYNDIALGIAFMGNFVEKPPNEASLKAAQSLIQCAVAKGYLTSNYLLMGHSDVSNILSPGQALYNIIKTWPHFKH
Protein: Bromodomain-containing factor 2 (Q07442)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Bromodomain-containing factor 1
- Histone H4
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 7
- Histone H2A.Z
Sequence:
MSRTNMDTRHAHSALLAAPQSATANSRSSNSSSESSSNKNNINVGVGDDSGNVSAVSIDDGPHFRDIFHYGHEENYKLASSGITNLNSSSHAHQTLSPISISNASTPESFPEHPLGLERETEPALEAEMEAEELPPHQSKYLLSSIKATKRLKDARPFLKPVDPIALNIPHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQKYFEKKLSAMPPRVLPASALKKTSRNRKKNEDMDSPLVIRRSVSTTNDNIGESGNREGVSGGRPKRTIHPPKSKDLFDIYENSKPKSKTLQKKFRTCLKILKVLMSKKNSDINFPFLQPVDPIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEVHSMGKKLKELFNFHWLENQDILNEIETDSDLEEDNYSSSYSSDDEYDDEDINENDITNPAIQYLEQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLKKSITDKINELSDLEMNGMIRIIKNSLPADEILTSNEDEIEIDLDILDEATIARIYERYFEKKNNNNSKRKLSGNYSTAPTNKKKKTLKFLEKDEIINNNNYSDSEEDSSDSSDSDSD
Protein: Ecdysteroid 22-phosphate (Q0PCR8)
Organism: Bombyx mori (Silk moth)
Interaction partners:
Sequence:
MTDTEERDRASSVLRDVMLRLHYCAVAELQPLSSGGANYTSLLYRARLQAPGRPDLRLFVKVAKMSENVRAHAINSVYDTELLVYEELSKLYRALEEERGVAEPERFVFPALYGARSRRLEEALVLEDLRASGFGPRDRLRPVDWEYACAAMEQLARLHALGFALQLQAPEQYERLARRVEMRFDLESTGAWSSTVELALAATRPEHRARLQTALASPAARFLHHYTALRRSTLVHADYRTCNLMHRRHQGGALEVRVVDYQKVQRGSPVADVLYFVFTGSDEEFRARHLRPLLDHYLQRLHAALGRLRLDPLTVYSAQDFEYELKEKLPFGLKIAVYTLPVITVEEEDAPELGTDFDSFKVKKTSSRFPARINGIVDDYVRWGLI
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (K7EL56)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEP
Protein: T-box protein VegT-A (Brachyury and Tbx-related protein) (T-box protein Brat) (T-box protein Antipodean) (P87377)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor required for both mesoderm and endoderm formation in the embryo; signaling determinants and concentration levels may determine which germ layer is formed. Acts together with beta-catenin to activate genes that are responsible for mesoderm induction including wnt-8, eomes t/bra, siamois, mix1 and sox17. Directly binds to promoter DNA. Patterns the mesoderm along the dorsoventral and posterior axis. Activates siamois gene transcription when alone or in combination with beta-catenin, but inhibits siamois transcription in combination with pou5f1.1/oct-25.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:9012531}.
Interaction partners:
Sequence:
MRNCCRECGLSAGHLEPEASSNCASDVKSSPDMDSVSSQDSLYLPNTVGASLEDQDLWSQFHQEGTEMIITKSGRRMFPQCKIRLFGLHPYAKYMLLVDFVPLDNFRYKWNKNQWEAAGKAEPHPPCRTYVHPDSPAPGAHWMKDPICFQKLKLTNNTLDQQGHIILHSMHRYKPRFHVVQSDDMYNSPWGLVQVFSFPETEFTSVTAYQNEKITKLKINHNPFAKGFREQERSHKRDDVLKILQQSPSKRQKRKKWEDSPEADISDFPKAICVKEESIMDPAGVYQNWVSDHEANQGLTPHSPESEGANQEQQVPTSSSNFYNKSHYRRSSQHLSSPFELGEPSSRRLTPDIATVPDSDPDSLAVFHVIPTQNSAPERTCSMNFSMEAPMKQPLRGAMYSPYGADQWLVPAQGQYRPVGYTAYPTDLSTQGAVAHPHSAMSDWSQYSLFPYSCW
Protein: Crg1p (A0A1D8PSY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Squalene synthase ERG9
Sequence:
MSGANNNHQVYYSKGFEKSISDTHSWRTVENSAKYVIPLIKPNIKILDVGCGPGSITIDFAKNYLSSPETNNNGSGSGSGGGGGGGSIIGIEPTQELIDIANENKSKLVPELTNISFQIGSIYELPFDDDSFDLVHAHQVIIHLQNPIEALKELKRVTKPGGFICIRDADLESSIVSPVEKYESLREFYVIKAKNAISTDTKAGRKLRNKALEAGYESKNLKTFSSSWLLADDLQIKKSWANATINRIKSDVEKLNVNDPMKNKQMNEKFIKLWQEWSEDETSLFTMIHFEIIYQKPTTTRQV
Protein: Serine/threonine-protein kinase smg-1 (EC 2.7.11.1) (Suppressor with morphogenetic effect on genitalia protein 1) (O01510)
Organism: Caenorhabditis elegans
Function: Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15314158}.
Interaction partners:
- Regulator of nonsense transcripts 1
- Nonsense-mediated mRNA decay factor SMG9
- Nonsense-mediated mRNA decay factor SMG8
- MIF4G domain-containing protein
- Nonsense-mediated mRNA decay protein
- PIN domain-containing protein
- Eukaryotic peptide chain release factor subunit 1
- RNA helicase
- UPF3 domain-containing protein
- DAF-15
Sequence:
MITSRNNDIGNLIEQFRQRDTPQKERKAILARIEEILQTTKNVESLCVKWTYLLDNLCWPSLTKHDRNDMKTLAGKVIRLVGVLLFDTESYPEFLIYLGTLYQSVTKKSEETRADIVFSVYFIVGVISQKTENRLIATDTENVEKSLDWIIKVLPNSSISVYNHCLKGFVLVANTFPNVYAAMFESTLRAILTNLPDFNSHEKNFELLIDTVMRFSDQLNEKPHLAEEMVRIIRPDIKKNGLGNMRELKKRMKLTMALVKMAKSQKMLEETNQMISEMSIELEENGGKWSSASLITIVCDVFNELLILGKDDVKLQKGVEESLCNVLKDLNLSNQSTMEKQAFFNSLAKIVKQLPAESQVKTRVHQIVFNTETGLFTPKNRDNRMFGHNMIYKDLINLVSVLLTPTSLNHLQATYTDLRKIMIDSMSRLKQSEDTPYSDNIRWNESILLLFFSSLQSISCAKSSLIVMMGIRPSIFEFFSSELPLTEYWLASNHPEVYHLFITIFVGHLKAHDFYIVQSDYIVRGDSIGQSIGQTKRDYARKQVVALQKIINNFGDKLWKKTRLMISSWLHSLIATACEHQIGSDSFSQREWVRLRNTVIHQSVLTWNNECVNQALTILSTATKWSELTSDIHRDIADKTKKAKWKEATTIWESGDCNTYIRQSMSTVYQMSQERQQKTITSTSFGAEEFIIITNFLLKQATPTTFKKGQNSWMDEVLETFTQGCRTLEKPDSYVPETFIEKWDWIINQTANFCIVNKMKTPLGKPMQTFAAFENEIKRLAKEVIVRKNSDKKLNKSSTEDPNQSPPLKYSVQWLRVHLLLKLIVVLEKLMNSAIHGGSSVFNLTEIPVSSRQFFTVNAASCEVWLNRVYYPALLVAYFNGYYGLVIRFGSNALSHFARQKDGDNDKKIVNGVCTASLMSLSMAVLGEPMEIVGLRRKVREEFGTDMGQSLMEALGEMANARYETALVALEAVLVTDAATNETLKMIIQLAMVDILNRIRLPQATDYYKVVLFGEESNDSTITEDFRSVELLTKFEKLNNTVNEKRQVVDWSARERFQFVESAFSQTMRRTELLDIQKDFSAMGALALSADSSCKLYSDISSTSLIIANLVNKMTGVSQWKNKLTDTEIFDRNEEGNDGDKLAICRKLMHWGRHTKSNRGQSCAAHSEIIRLSRKTSNCELAFFHINSAIRGEKLAAWQRLEVERQRLKLVKTQNLDVRIREMNEVFGSLAEVFTTSCQLKSDFQMVDGMIKEKMISEGYNEDIAKREEHMSRASIQLADFFQSLPELENVLAPNLFPTIIWSELQRRSDSLSAGYHGIVGSLFHLASEMCPSLAKAHLKMARWAYEIAKIKNFPAENLSFYKFGKDETENEELLKSLEATSLVNLEKLVRAAISDDLRANNILAPNSHFMHIWKMVRDHRTKFLSIAVTSYFQFIQNMSGDCDNLPYSKKEETTLATLRILELLVKHGDVLIDVINDGLNKTNVHIWKEILPQLFARLSHPSEHIRKTLVDLISKICTAAPHAVVFQVVSGAASSSTDGEELEEQQNDDRNRVRACCEKLETNMSQSYPNLVKDVRQFVAELERINLLNEEKWSVVMGTMEHEMEKRLSLIRTENAKTESALHLTASVKNDIIVKRTQLLTRQIFDVLDELYQQTVIEPPKSKNEEEFVTAFAEVLTNAFQESRISRTTSPEKSWIPFKNLIANFVHRNSKKGMQTFETEDISPYLASLSNSCVPMPGQESVEFDRVVSISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKKNGETVPEIERPSNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDWTSHEHTATSGVSLALQLAVYGSNWKTKAKERLTDAMELLNLRMSEVQTLWLANRDDLLHWMKQVTECLLIENSMLGANAIYAQQRVKAGTELREAVTRHHALAKELRPLIRVIGKEREEFADYLKFYKQALFDPLLKGHSALRNELDIDTCVYNFNIVMQNIDNVFGALVNLSFTPIETITSRTSQQEFKPPPGLENVWVVKQDQQENSQAREVVRRVERRLNGWLDGSAGPDRKLSPREEADILIAEATSTPNLSQMYEGWTAWV