wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor MYB111 (Myb-related protein 111) (AtMYB111) (Protein PRODUCTION OF FLAVONOL GLYCOSIDES 3) (Q9FJ07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis primarily in cotyledons and leaves. Confers tolerance to UV-B.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Flavonol synthase/flavanone 3-hydroxylase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Transcription factor TT8
- Dihydroflavonol 4-reductase
- Flavonoid 3'-monooxygenase
- Protein TRANSPARENT TESTA GLABRA 1
- Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase
- Chalcone synthase
- Transcription factor EGL1
- Leucoanthocyanidin dioxygenase
Sequence:
MGRAPCCEKIGLKRGRWTAEEDEILTKYIQTNGEGSWRSLPKKAGLLRCGKSCRLRWINYLRRDLKRGNITSDEEEIIVKLHSLLGNRWSLIATHLPGRTDNEIKNYWNSHLSRKIYAFTAVSGDGHNLLVNDVVLKKSCSSSSGAKNNNKTKKKKKGRTSRSSMKKHKQMVTASQCFSQPKELESDFSEGGQNGNFEGESLGPYEWLDGELERLLSSCVWECTSEEAVIGVNDEKVCESGDNSSCCVNLFEEEQGSETKIGHVGITEVDHDMTVEREREGSFLSSNSNENNDKDWWVGLCNSSEVGFGVDEELLDWEFQGNVTCQSDDLWDLSDIGEITLE
Protein: Uncharacterized protein Rv2557 (P9WLA5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv2558
- Metal-dependent hydrolase
- TIGR03085 family protein
Sequence:
MTGGATGALPRTMKEGWIVYARSTTIQAQSECIDTGIAHVRDVVMPALQGMDGCIGVSLLVDRQSGRCIATSAWETAEAMHASREQVTPIRDRCAEMFGGTPAVEEWEIAAMHRDHRSAEGACVRATWVKVPADQVDQGIEYYKSSVLPQIEGLDGFCSASLLVDRTSGRAVSSATFDSFDAMERNRDQSNALKATSLREAGGEELDECEFELALAHLRVPELV
Protein: Kalirin RhoGEF kinase b (EC 2.7.11.1) (A0A0R4IJ99)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein kinase domain-containing protein
- Rac family small GTPase 1a
- Mitogen-activated protein kinase 6
- MAP kinase-activated protein kinase 5
- Serine/threonine kinase 17a
Sequence:
MRSWRSCCSSGVCLSWIIRKICCCDGAENYPVGSSEVKSESAASLQPQTSVTSLPTGSPGPKRSGTTGNTLKKWLTSPVRRLSHGKGDNANAKKPNNKQRKRDGRKSVELGPHHQDSTEERGRRGTNSGGEEEAEDEPHTPLPPPMEIIKDPSAQEDKTPERGSFPVLGSDTPSDQTPRDPETEQKNKALRGRMFVLNEMVQTERDYVKDLGVTVEGFMRRIGEKGVPEDMTGKDKIVFGNIHQIYDWHKEFFLCELEKCLQDHDKLAELFIKHERRLHMYVIYCQNKPRSEFVVAEYDKYFEGVQQEINSRLAISDYLIKPIQRITKYQLLLKDFLKYSTKAGLDCKEIEKAVELMSLVPKQCNDMMNLGRLQGYEGKLTAQGKLLQQDTFFVTEQDSGVLSRSKERRVFLFEQIVIFSELLRKGSSTPGYQFKKSIKVSYLSMEEQVESDPYKFVLLCRGSSERLTLQAANVDIKKEWVQSIRELLDMQINFLTALQNPQAALTSQLSNSNRSSSSQPSTPLKPNTAPNGSPAQKNNKHAEEDLDEGECNGLSSVLVTQDYNAVKEDEICVVVGEKVQIMASNQQNMCLVYRPANSQSPAAEGWVPGHVLSSTR
Protein: Protein lag-2 (Lethal protein 461) (P45442)
Organism: Caenorhabditis elegans
Function: Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling. Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs) and in the postembryonic mesodermal lineage (M lineage), acting redundantly with dsl-1 and apx-1. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. Required for oocyte growth control, acting redundantly with apx-1, perhaps signaling via the glp-1/Notch pathway. Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons. Involved in maintaining the developmentally arrested larval state known as dauer, probably signaling in the glp-1/Notch pathway. Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals.
Subcellular location: Cell membrane {ECO:0000305|PubMed:7607081, ECO:0000305|PubMed:8139658}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Protein lin-12
- Suppressor of hairless protein homolog
- Protein lin-3
- Protein lag-3
Sequence:
MIAYFLLLLTCLPVLQARVEVHQEFISSKRVSVRFEIVTESHSPNRPVTFDLFPRGPKTNIILLDTFNPVFNFSIQLVQPFTGQPLGDRIYRKVQFSGTNQPWINDTFTTTSGISLSVATEVTCARNYFGNRCENFCDAHLAKAARKRCDAMGRLRCDIGWMGPHCGQAVDPRKCSCENDGICVSSMIHPSQPNQTSSNEQLICECTNGFTGTRCEIFGFNQFQLTAPRPDACSVKDACLNGAKCFPNGPKVFCSCAVGFIGEFCEISLTTTTPTTVEITVSTSGYSSAVYITVALFVIFSIIIGCFKYKFKPMRQQALARGQVPEPYKMPETKSMLIDPEASEAQKKVFTIEGSVQKIDEEVRYTSAPRKYESNNEYAVIQKSTPPPPSLSPPSIPACHYV
Protein: Spt20, isoform C (Q2PDX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQSLDSSCQEADFIINDTLKKLKGSSNADHVQGLAVHAHGSGVHQTQFVQYGTSGSSPQLQPQQSYHQLHPTLQQQQFASSSSKSYLETSLLQAIPQIPAQPPICIFDDDESPTEGTGGSLGSLLTEPTSATPSGLPTAIAPSPSSCSSSTTTMSNFNSITSPSPVVPDLLLSTPPGVNSSLSNSSTGAASVSSKKSEKRPPSANSTASGGGHHLHHHHLHQTHNHHVLASPTSSPSKRQKSNSSSKESSSSSRSSAIPAASVSTATSSSQSARAGAGAASSNSNSKPPSSVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFTLERLVDREKLNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQDESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYAKPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGSQLPAEDKLALESQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHGLELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRPPTLEYPANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNCRHNFQPQLVEEYILETEREASEGRRALYHIKLSIFQRPSDAEYLGELYVDRDYREGERNGESCRFALGTRVHANRYIQQFREIFTEEGRKAVKITHLIPGHMPIVTHTGLTNEQRILLQQQQQQQQRQAQMQQQQQQQQQQVVVVANQQQQSQQQQQTQQAGQQLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTYTIEAPQQQAAAQIVPQQQQQQQQQQQQHIHLQQLATGSSNTSTTTHQVSLSNGSLVLVQQQQPQQQSQQLAQALQHSGITIQPATIQQQQQQVKGTSVVGANSALRAQLNSNVPILQTQLKVQQQQIMQKQQQQQTTATSNNNNNNNNNNNMNNNTAIHPNPAINAIVNSIMNSANQYQQQQQQQHQQQHQQQTGNTSSNNNAAGSGGSTNNNGSSTSATTLKNSSNASILNLLNSAPAAMTSTPVASGTFTTSTGQQQPQTLTLVQHQQQSTPNTADAATATYVQTTRGTPTLVSTQRKQQSSEVLQNLLNANRKIGGGGTTTTTFRTNSAGNLIAVNLNQAGQSHHQQTGDGSQTVRVSMSALASQLASPPAVMTNPTTSYTVISSGNSAAAAAAWIQSPTGPVQQRILSSLRRDSTTAPPNAIVVGMAAPSPGSDSNASNASGFAVPNNLASTSSGGGGGGGALSALLTNAATPSPSGSDHSQSSQTHQNQALLERLSNVTSNVSAVSMPHMSPQQPQPTQQFITKTIVHSPATSSIHSPMSSPHPQPSASPQQQQQQQQQQTTATLNLQGINLSQLQGAMANFAGLQNVQVQIPGFTQPISLQFSGNSLQQQQSGNTATGAGTAQGQQRSVLVSVPVSSQQQQLPHTITLQTQSAPHHQQQHQQTQQQHAPPTGTIVSLPSSGPGTQTVVITNNSGGGVTAGSSTSGSAGGGGGSGATTAMLTLPIV
Protein: TATA box-binding protein-associated factor RNA polymerase I subunit B (Central cell guidance protein) (Protein MATERNAL EFFECT EMBRYO ARREST 12) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Q5XVF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity). Required for the development of the one-cell zygote and endosperm in embryos. Required for micropylar pollen tube guidance, but has no effect on ovule development and gametophytic cell fate specification. May regulate the transcription of secreted cysteine-rich peptide (CRP) genes in the embryo sac.
Subcellular location: Nucleus, nucleolus {ECO:0000250}. Nucleus {ECO:0000269|PubMed:18055609}.
Interaction partners:
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Transcription and mRNA export factor ENY2
- Ubiquitin C-terminal hydrolase 22
- SAGA-associated factor 11
- Transcription initiation factor TFIID subunit 12b
- Transcription initiation factor TFIID subunit 12
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Histone acetyltransferase GCN5
Sequence:
MICTECENDAFDEEDDGYYYCQRCGVQVENLIQTGVDDGDLIGEGGGTQGALYNPKHRRTEPQPITPSQPRFTDDTSRYSQFKSQFESENGNKELPREVKRAPDSYVDKEPTEPVDFAAETLSYENYYDEARDRYVKAFLMMITYQCDALVDKFNVTPLIIGLVGPISLRYVALSGVYHKDWANNAIRDSEHQSEDGEVKDAKRLKRHKAEPRNIDGKRAVTIWFGILKKTMPLSSSLVISFLACHQAGAPVLPTDIVRWAREGKLPYLSCFLDIREQMGERSAACPVKVSIMARPFQVISAQMLEARASVIADTIGLPLPPVNFYGIASNYIKQLSIPEDKILDLARLIQNWSLPPELYLSTNEQKLPSRVCVMSILIVAIRMLYNINGLGVWERSLGFVNASDGDSETNSGTAEKATEFDTQELLKNLEAKYHEVAAETLESEKDLVSYLSLGKNEFFAGLEEDSPDDTYRIVDNLWNGYPKDEDIECLPKRGRDWDDDVSLNQLSLYDSRFSDGNNPCSSSSRRNESVSIGLDLSSSEHRESSSPEKLKEIAIKRLITDMGDDLFCYIPPRVKVKRLDYLQYVRKKEDGALIYAAHADYYILLRVCAKVAEIDVRNMHRGVLSFERRLAWIEKRIDQVLHLTRPLMTCKHCCDDGNIGEDQDD
Protein: Egg cell-secreted protein 1.4 (Q9T039)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:23180860}. Secreted {ECO:0000269|PubMed:23180860}. Note=Secreted via vesicle exocytose upon sperm arrival, especially in the apical region of the degenerating synergid cell.
Interaction partners:
Sequence:
MASNTTFLFSTVTLLIILLNTTVSGRDLPAESSTNIAARLQSGGLMECWNALYELKSCTNEIVLFFLNGETKLGVSCCESVDIITTNCWPAMLTSLGFTPEEANVLRGFCQNPNSGDSSPAPSPKIV
Protein: Peptidase inhibitor 16 (PI-16) (Cysteine-rich protease inhibitor) (CD antigen CD364) (Q9ET66)
Organism: Mus musculus (Mouse)
Function: May inhibit cardiomyocyte growth.
Subcellular location: Secreted {ECO:0000269|PubMed:17909105}.
Interaction partners:
Sequence:
MHGSCSPWVMLPPPLLLLLLLIATGPTTALTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEGMDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGYSCENSLCEPMRNPEKAQDSPPRVTEVPSTRATEAPSSRETGTPSLATSETLHFSVTKVSDSLATESSPAVETKAPSSLATEGPSSMATEAQAFVTEVPLVSARHMQPSVDEGPVNFLTSTHIPVPKSMDEEASKSSATSVSPKKSLYPKMSLTESGESVPQIQEEAEPKDELSEPEAILPEAEAAPTEAEVELREPEAESPKAESPEAEAESPLSSEALVPVLPAQERGGQKASLEHSGHPASPSLPTFPSASGNATGGRTLALQSSWTGAENPEKADWDLKNSAHVWGPFLGLLLPSLLLLAGMV
Protein: Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen) (O35348)
Organism: Mus musculus (Mouse)
Function: Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
Subcellular location: Synapse {ECO:0000250}.
Interaction partners:
- Muscle, skeletal receptor tyrosine-protein kinase
- Acetylcholinesterase
- Cholinesterase
- Protein Dok-7
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Proline-rich membrane anchor 1
- 43 kDa receptor-associated protein of the synapse
- 2-hydroxyacyl-CoA lyase 1
- Acetylcholine receptor subunit epsilon
- Acetylcholine receptor subunit alpha
Sequence:
MVVLNPMTLGIYLQLFFCSIVSQPTFINSVVPISAALPGLDQKKRGSHKACCLLMPPPPPLFPPPFFRGSRSPLLSPDMKNLLELEASPSPCIQGSLGSPGPPGPQGPPGLPGKTGPKGEKGDLGRPGRKGRPGPPGVPGMPGPVGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGFPGSRGEKGSRGERGDLGPKGEKGFPGFPGMLGQKGEMGPKGESGLAGHRGPTGRPGKRGKQGQKGDSGIMGPPGKPGPSGQPGRQGPPGPPGPPSAGQLVMGLKGERGFPGPPGRCLCGPPVNVNNPSYGDSMYGRGSPRVPAIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVGYTVKQPGTCGDGVLQPGEECDDGNPDVSDGCIDCHRAYCGDGYRHQGVEDCDGSDFGYLTCETYLPGSYGDLRCTQYCSIDSTPCRYFT
Protein: Probable vacuolar protein sorting-associated protein 16 homolog (A0A1D8PDC9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Vacuolar protein sorting-associated protein 41
- E3 ubiquitin-protein ligase PEP5
- Tethering complex ATP-binding subunit
- CORVET complex membrane-binding subunit
- CORVET complex subunit
- CNH domain-containing protein
- CCZ1/INTU/HSP4 first Longin domain-containing protein
- V-SNARE protein
- Vam7p
- Tethering complex subunit
Sequence:
MPSNPSFNWSKLQNVYYNIRTCYDEMDWSIDNLYSNYLVSLSPNTTLIAIASKSAPHPNLIEIYSNSGHKLWSVVYNSTHNDYIQSFHFTSDEDLIIVLNNGRYRHYYDLIGSFNEYNFVEDLVTMDNISQRHNTGDKIDANPDNTRIITNLENNQTEEIIKIIEVKTWNQFLVVRLESKIIVSDLDSFTNYAISLASYSASDFECFSIQAKTGTKKAVTIQLGYRKSILSIDVDFDLASYEILDQELTDGPFSSIAISPSGQLISLFNQQLKKIFVISNKFDQILLDYDTSNESSDPYQVEWCGNDAIVLSFKDEIKLIGPGQQSISFFYDIEDDDEFDLDNLMVRKDNKNTDYKKFDDLLFTIPILQTSIDGLKIVTTNKVQFLSRVPETSVEMYQVGSTAPSSILADCIDKFSANASKADSNISLLRADNTLLKAMEDCLQVALDEFSPDWQRRALKAVSFGKVYYDDYFDSDKFVSVVDIIKVLNLIRSPELGLFLTYQQIEKIGGWEEVIKMLLRRNHHDLSLDIIDKLNLGNAKPLVYIHWCCYKIRKELDMSDIDLFKLVSEKLISSTKTRVNYISTEQISETAHEEGREELCKFLLDLEPSVIKKIGKLLNFDETELALIKSFQNGNYDLSTLILLYLQDNLTTSQFFKILSQTESVLKKENSTKQTIQKLDIDVKSEYMQVTGEVVGHAWEESIAKNVSPRLLETYLKHEDRVNELNIFKIQQFKRDPELHKDNYYESYKSVLTKAINRSTNQRISKALQREIQVLELQKKLSETYLTDFYQEKTLMAILKRMIAMNQIKPAKKIVANFQLSVEKFWYLVLNTLMDRREFDQLYEFAFGSSDQTSGNSPIGFEPFAELGLQKNAPQSHISTYIKNSNKYKYEEKISMFIKNDDYESAALEAFRNKDIDILKSLLQKIPNSNQADIQVVNSYIQQLGY
Protein: Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG1 (EC 3.2.2.n1) (Protein LONELY GUY 1) (Q8RUN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19837870}. Nucleus {ECO:0000269|PubMed:19837870}.
Interaction partners:
- Cytokinin dehydrogenase 7
- Cytokinin dehydrogenase 3
- Cytokinin dehydrogenase 5
- Cytokinin dehydrogenase 1
- Histidine kinase 4
- Adenylate isopentenyltransferase 5, chloroplastic
- Adenylate isopentenyltransferase 3, chloroplastic
- tRNA dimethylallyltransferase 9
- Histidine kinase 3
- Adenylate isopentenyltransferase 7, mitochondrial
Sequence:
MEIESKFKRICVFCGSSAGNKVSYKDAAIELGTELVSRNIDLVYGGGSIGLMGLISQAVFNGGRHVIGVIPKTLMPREITGETVGEVKAVADMHQRKAEMAKHSDAFIALPGGYGTLEELLEVITWAQLGIHDKPVGLLNVEGYYNSLLSFIDKAVEEGFISPTARHIIVSAPSAKELVKKLEDYVPRHEKVASKKSWEMEQIGLSPTCEISR
Protein: Genetic interactor of prohibitin 7, mitochondrial (A0A1D8PRH4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MSSRARPTKRKRRVKEKKKKILPLDLQLTSHNQPPPPPPPPRLMSLITKTIIFKRTLTTKFSTEEAKKQAAAQLAIQSLKDFGSLLSNSSEDTQPIDTQPIYNNPELFASLSLLHQGQVIKELQDKFDKDWLKLTLKDKKLSYYIAYGNWGVREKFINWNNPNEPPLDLPFKLPTTTIIKSRNPADDVKTKTIIKKLPMVNLNETEVRKEQFDIKRMDGVTKFFIYLMIFISLLAIARDKNIGENGKPEQIIIEDKYEIQRQERLKKKEEEEEEEEEKEKERLRIELEEKRQFELAKKNKKWYYLWLK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0R4IN78)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Striatin
- Striatin-interacting protein 1 homolog
- TRAF2 and NCK-interacting kinase b.
- Programmed cell death protein 10-A
- Striatin-interacting protein 1 homolog isoform X2
- Caspase 7, apoptosis-related cysteine peptidase
- Caspase 3, apoptosis-related cysteine peptidase a
Sequence:
MAHSPVQGSLPGMQNLKADPEELFTKLERIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPFVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGSLDETQIATILREILKGLEYLHSEKKIHRDIKAANVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSDLHPMKVLFLIPKNNPPTLEGNYCKPLKEFVEACLNKEPSFRPTAKELLKHKLIVRFAKKTSYLTELIDKYKRWKAEQSRAESSSDESDSEPDGQASGGNDFGNDDWIFTIREKDPKKLQNGASLVGEEEPNKRPLSQSLSTVITPVLTELKEGAGEAAAATTVKPEVLEQLGEAIFLAEEAYPGISDVMVTQLIQRLQRFSRARTSSSSHQ
Protein: Regulator of drug sensitivity 2 (P19541)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor which regulates the expression of genes for gluconeogenesis, the TCA cycle, and glucose metabolism. Involved in the cell wall remodeling process and drug resistance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Regulatory protein CAT8
- Protein SIP4
- Regulatory protein ADR1
Sequence:
MSANSGVKRASKAFKTCLFCKRSHVVCDKQRPCSRCVKRDIAHLCREDDIAVPNEMPSQHESSPNDNNIQGKYANKAHTGIPSDYQNEPVNKSGSTYGEELSPKLDSSLVNDTTSLLLPQQPVFVSENVGSEFSSLNEFLSMLENPLLTQTSLSSSSASNVHLENGSQTTQSPLEYQNDNRRDEIGVARQENRSPTIMSGSSNSISKGDKQDQEKEESRILANANENSAPTPKEQFFLTAADPSTEMTPEHRLKLVINAKLEAGLLKPYNYAKGYARLQDYMDKYMNQSSKQRILKPLSTIRPAFRTIARSLKDVDLVLVEESFERMLLSYDRVFTSMSMPACLCRRTGEIYRANKEFASLVDCTVDDLRDGKLAIYELMTEESAVNFWEKYGSIAFDKGQKAVLTSCSLRTKDGIRKRPCCFSFTIRRDRYNIPICIVGNFIPLS
Protein: Stau1 protein (Q66HP4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
RRPPSPQPLRLFPPPVFFSSPSSFAFLPRRRPIPPAPGRALGKQPESIASTIELNALCVKLERKPMYKPVDPHSRMQSTYSYGMRGGAYPPRYFYPFPVPPLLYQVELSVGGQQFNGKGKMRPPVKHDATARALRTLQSEPLPERLEVNGRESEEENLNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTRVSVGEFVGEGEGKSKKISKKNAARAVLEQLRRLPPLPAVERVKPRIKKKSQPTCKLQTAPDYGQGMNPISRLAQIQQAKKEKEPEYMLLTERGLPRRREFVMQVKVGHHTAEGAGTNKKVAKRNAAENMLEILGFKVPQAQPAKPALKSEEKTPVKKPGDGRKVTFFEPSPGDENGTSNKEDEFRMPYLSHQQLPAGILPMVPEVAQAVGVSQGHHTKDFARAAPNPAKATVTAMIARELLYGGTSPTAETILKSNISSGHVPHGPRTRPSEQLYYLSRAQGFQVEYKDFPKNNKNECVSLINCSSQPPLVSHGIGKDVESCHDMAALNILKLLSELDQQSTEMPRTGNGPVSACGRC
Protein: UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (O70475)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development (By similarity).
Interaction partners:
- UDP-glucuronic acid decarboxylase 1
- UDP-glucose 4-epimerase
- UTP--glucose-1-phosphate uridylyltransferase
- dTDP-D-glucose 4,6-dehydratase
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase 2B17
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
Sequence:
MVEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNEARINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIREADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSADDQVSRLVTISKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHSELQTIGFQIETIGKKVSSKRIPYTPGEIPKFSLQDPPNKKPKV
Protein: Aminopeptidase (EC 3.4.11.-) (Q5BCU2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MCGTRRAEAAGSTNVPGREVLPTNVKPTHYDLTLEPNFETFKYDGTVIIDLQVAEDTTSISLNSTEIDIHTATVSAQGSVVSSSPEILLNKDKQEATIKFSETISAGSSAQLKLTFTGTLNDNMAGFYRSSYKTPQGETKYIASTQMEPTDARRAFPCFDEPALKAKFTVSLIADKSMTCLGNMDVASEQELEGGKKIVKFNTSPVMSTYLVAFIVGHLNYIETKNFRVPIRVYATPDQDIEHGRFSLELAAKTLAFYEKAFDSEFPLPKMDMVAVPDFSAGAMENWGLITYRIVDVLLDEKTSSASRKERIAETVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNSFYPEWKVWQTYVIDNLQSALSLDSLRSSHPIEVPVKRADEINQIFDAISYSKGSSVLRMISKYLGEDIFLQGVRNYIKKHAYGNTQTGDLWSALANASGKPVEEVMDIWTKNVGFPVVTVSENPTSSSIKVKQNRFLRTGDVRPEEDTTIFPVMLGLRTKQGVDEDTLLSEREGEFKLPDLDFYKLNADHSAIYRTSYTPERLTKLGEAAKAGLLTVEDRAGMIADAGALAASGYQSTSGLLSLLAGFDSEPEFVVWNEILTRVGALRAAWVFEDAQTKDALEGFQRALVSDKAHTLGWQFSENDGHIIQQFKALLFSAAGNAGDKTVVQAAQDMFQRFAAGDISAIHPNIRGSVFSIVLKNGGKKEYDVVYDRFRNAPTSDEKTTALRCLGAAEDPELIQRTLGLALGDEVKNQDIYMPLGGLRNHAAGIDARWAWMKDNWDTLYQRLPPGLGMLGTVVQICTASFCTEEQLKGVQNFFANKDTKGYDRAIEQSLDAIRAKISWVQRDRADVGSWLKSKGYLPGNGKL
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit (Q99PC9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSYKLKKDKEPSKLAKGTAKPSSSSKDGGGENTDEAQPQPQSQSPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSFPFNLNKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKCKEVKRAGLNEMVEYITHSRDVVTEAIYPEACHHVIQVNLFRTLPPFIESHRSLTPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKVFLVRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKKVMFLNELGEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARILPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
Protein: MBT domain-containing protein 1 (Q05BQ5)
Organism: Homo sapiens (Human)
Function: Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).
Subcellular location: Nucleus {ECO:0000305|PubMed:27153538}. Chromosome {ECO:0000269|PubMed:27153538}.
Interaction partners:
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT5
- Mortality factor 4-like protein 1
- Bromodomain-containing protein 8
- YEATS domain-containing protein 4
- RuvB-like 2
- DNA methyltransferase 1-associated protein 1
- RuvB-like 1
- Transcriptional repressor protein YY1
- MRG/MORF4L-binding protein
Sequence:
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEVPNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWCNICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRENQSASSKQKKKAKSQQYKGHKKMTTLQLKEELLDGEDYNFLQGASDQESNGSANFYIKQEP
Protein: Homeotic protein proboscipedia (P31264)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps.
Subcellular location: Nucleus.
Interaction partners:
- Homeotic protein Sex combs reduced
Sequence:
MQEVCSSLDTTSMGTQIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRGHNNNTPSATNNNPSAGNLTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEESSPIKVKKKDDGQVIKKEAVSTSSKASPFGYENSTPSLVSFRRDSDASAVGNAPTSKAVGKKRFQSAANAIATPTPLSDSNSGNGSGGGPAGGYFPGYYPSPKQQQQVQQQQLHPQQQQLPQQQPQDYYGKYDIEFAASPHHNPHNKQQALHGEYLSPKPSSANFHQNSQQQQQNDHFYYNYNDTNGTPYLNHQQQHHHHAQHHQQQQHHQNHVADFEGPVNGPSNFNNGAYYDNMSFQQQAQAHQHQTVVFQQQQPHQPAAINHQHMHHLGNGETYSALGLQMENCEGYNNFGAAGTGGGYYEAGQQPPIPATHGHGHHPHHVQVPAQAHAPIHAHHNSAAIPGGVGVGPPPSHIHGFAINGGPAVQGQAFGNNGSTAAGTAAISGLENSNSSDFNFLSNLANDFAPEYYQLS
Protein: SD10629p (Sprouty-related protein with EVH-1 domain, isoform A) (Q7K0G4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTEGHESDFLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRISDQSVILSCVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIICPPLTKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLPPPPIHYISTDKTSATTSPPDAPPASAAPSPATAGQIAASENYSYVTLTAVHHDYNYPVVDQPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGLACRDGGSGKPLHKPNVSDILKKETRLRCRYCHELYSEDFNRRGACEYAPDAFRSGYECISGMGCARCMIYHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGLCGGQHKPHV