wanglab/gogpt-training-data huggingface dataset:
Protein: Rap GTPase activating protein 1, isoform F (Q59DZ5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKYLTNTHKESYTLVARKRYMKNLLRQHAFMANTQKQQPAGGGSGSGSVTHSPERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEATTKACSLCLDGVQSTIMGSSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVTCQRDIKRLRERELSLQGDLSAAGREILRLRDLLKEYMPDTASAPLSISPI
Protein: U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4) (Q96G21)
Organism: Homo sapiens (Human)
Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:16533400, ECO:0000269|PubMed:34516797}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein MPP10
- WD repeat-containing protein 36
- Transducin beta-like protein 3
- Ribosome biogenesis protein BMS1 homolog
- U3 small nucleolar RNA-interacting protein 2
- Something about silencing protein 10
- RNA 3'-terminal phosphate cyclase-like protein
- Bystin
- Nucleolar complex protein 4 homolog
- U3 small nucleolar ribonucleoprotein protein IMP3
Sequence:
MLRREARLRREYLYRKAREEAQRSAQERKERLRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSTE
Protein: UPF0227 protein YcfP (P0A8E1)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YcfL
- Purine nucleoside phosphoramidase
- Thiamine kinase
- Beta-hexosaminidase
- Penicillin-binding protein activator LpoB
- Regulatory protein ViaA
- Cell division protein ZapC
- Esterase FrsA
Sequence:
MIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLISYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVIFNPNLFPYENMEGKIDRPEEYADIATKCVTNFREKNRDRCLVILSRNDEALNSQRTSEELHHYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG
Protein: Elongator complex protein 4 (A0A1W2PRF0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIEDWRKSLWSFPNLKI
Protein: Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) (P07205)
Organism: Homo sapiens (Human)
Function: Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Phosphoglycerate mutase 2
- Phosphoglycerate mutase 1
- Bisphosphoglycerate mutase
- Probable phosphoglycerate mutase 4
- Glucose-6-phosphate isomerase
- Phosphoglycerate kinase 1
- Alpha-enolase
Sequence:
MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVLMSHLGRPDGVPMPDKYSLAPVAVELKSLLGKDVLFLKDCVGAEVEKACANPAPGSVILLENLRFHVEEEGKGQDPSGKKIKAEPDKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGMAYTFLKVLNNMEIGASLFDEEGAKIVKDIMAKAQKNGVRITFPVDFVTGDKFDENAQVGKATVASGISPGWMGLDCGPESNKNHAQVVAQARLIVWNGPLGVFEWDAFAKGTKALMDEIVKATSKGCITVIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKILPGVEALSNM
Protein: Elfless, isoform B (Elfless, isoform C) (MIP08280p) (Q9VJB0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO02127p1
- GEO02513p1
- RH05790p
- GEO12089p1
- AT23551p
- Reduced ocelli, isoform B
- Centrobin, isoform A
- Ubiquitin-conjugating enzyme E2-17 kDa
- AT16033p
- Ubiquitin-conjugating enzyme E2 N
Sequence:
MGDSSDSDSSTEWEQNTRVISLPFSRNRSHLSSRLSYLVGLQMENFRTSNNSGVSQRIHNTGPTPVLAPSGLRSRLLSGSSERNPNEYYGDSDSSSSSRSIDRTPFLLEYSSDSESSSSSDSESSSTSISFDSSMSSTESSTPMGHTESSDSNEDSPPNKRIKSDDEESKKSVLPYNCPVCLEDVREKLPVSTNCGHVFCKACIKRAVDTGRVCPLCGVDEPEFHRIFL
Protein: Swi1p (Q59UR3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Snf5p
- SWI/SNF catalytic subunit
- Arp9p
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Npl6p
- Chromatin structure-remodeling complex protein RSC8
- Eukaryotic peptide chain release factor GTP-binding subunit
- RSC chromatin remodeling complex ATPase subunit
Sequence:
MSDWLNENAFADSNSNDDFLNSIFDQSQGEQQAPQVAQVSTSMSNPPLQSQSASSTSRISQAHTPMYQQSPVTAHTIPQNSPQSMPNQVAQPQQQIPPPPSQHLQQTTAQMLPQQQQQQQQQQQQQQKQEQLYRMKQQIYQQQMLKKQQENMSRQPSPMNSAGHNTQQNTPITQNAKTPQNNSKLQSMQMELFFSVLYDFLQRSGISIPQSLAINGKRVNLFILYILSQRLGGYRVMKAFLLMSPEQQRMQQQNPWALMADKMGFHDKGEDPMAKERIARELCNCYSNFILPYEEYYATPEGNKDIEASKHRFQQQIVQKYSSNVPTPAPNQQSPMISSAPTPHQQRKLSRTSNSVNNSPNVSSPFHNTPRQVPAPAPAPVQTAASMPPPTPVTAKSQTTKADAHILKNYTPFKKIVETHGPFNIKELSQLSTEIEVTKPVYLFAPELGIINLQALTMSVKSNSGIQSSEVVNALNTLLVATSDVNYAFQIKDIMELLDALSSLGKDVLNKIVGVNTEEDCVNADVTKLSANGRIDDIFNRYVKGQGEDISYVVNSLTGEVVSDDEDIEELFSVCDDGNSESPIDKSTDSLDVLEFHLDDYLTALKNFKSENKHHFSKLQTRSATDDQILLVDELITITMILRNISFAEYNKEPMAGNRLFKDLLFSTVKSVALNNDKFVFSRKRLCLLKDCLLMLDNISLFTHLHTLEEAFLSFVLVASFGPKIEDQYKIPRCNIETHSYFAFGLDAFTKLMVREPYNRSLIQAVLNGTLNSSMTGYSVSLQDQEYTRKLIKAYNKDYKSASLLSQAFQMYMSILPFDANTFELSKFIFMRSPTISQMLFGAKLLIDMVPVDDLNTHHNKLSLYWLLENRELLLGNFARIVVALSTETGKFPRESPEHKVLSSVLRKALVVINSLVDNAVLAKEIGDSRHTDLMESLTDCLAFPRIIPDAILTLDTFLAPTIDTNLGKEVVRLLRYLKDLKACEGI
Protein: Probable protein phosphatase 2C member 13, mitochondrial (OsPP2C13) (EC 3.1.3.16) (Protein DOWNREGULATED IN CW-CMS 11) (Q6EN45)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable protein phosphatase that may play a role as a mitochondrial signal transduction mediator in pollen germination. May function in retrograde signaling from the mitochondria to the nucleus. May be a downstream factor of cytoplasmic male sterility (CMS). CMS is caused by genetic incompatibility between nuclei and mitochondria within male reproductive organs.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:18308761}.
Interaction partners:
Sequence:
MVCFASLRRALPLLLRATTTTTPRFLLPRALSGGVGGGAAVDARALLRGHSGWRGLRVAARMMLDSSDSAAAAGQMQPQQRAAGAVACSAQDGGAAGYASGGWAREDGKLKCGYSSFRGKRATMEDFYDVKLTEIDGQAVSLFGVFDGHGGPRAAEYLKENLFENLLKHPEFLTDTKLAISETYQKTDTDFLESESNAFRDDGSTASTAVLVGGHLYVANVGDSRAVVSKAGKAMALSEDHKPNRSDERKRIENAGGVVIWAGTWRVGGVLAMSRAFGNRLLKPFVVAEPEIQEELVNEDLECLVLASDGLWDVVENEEAVSLAKTEDLPESVARKLTEIAYSRGSADNITCIVVQFHHDKTE
Protein: Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (Protein-tyrosine kinase MPK-6) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) (Q03146)
Organism: Mus musculus (Mouse)
Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Transmembrane 4 L6 family member 1
Sequence:
MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSSDTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGTPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQACSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFLADDALNTV
Protein: Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) (P16473)
Organism: Homo sapiens (Human)
Function: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Thyrotropin subunit beta
- Guanine nucleotide-binding protein G
- Thyroglobulin
- Thyroid peroxidase
- Glycoprotein hormones alpha chain
- Guanine nucleotide-binding protein G
- Homeobox protein Nkx-2.1
- Insulin-like growth factor 1 receptor
- Follitropin subunit beta
- Sodium/iodide cotransporter
Sequence:
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
Protein: RNA-binding protein Y14 (AtY14) (RNA-binding protein 8A) (F4I9J7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGO-Y14 heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGO-Y14 heterodimer interacts with the EJC key regulator PYM leading to EJC disassembly in the cytoplasm (By similarity). Can increase in vitro the expression from reporter constructs that contain leader introns required for the expression of different genes. In association with MAGO and PYM, participates in intron-mediated enhancement of gene expression. The MAGO-Y14 heterodimer works synergistically with the NMD pathway to regulate male gametophyte development.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:19435936}. Nucleus speckle {ECO:0000269|PubMed:19435936}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y5S9}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. {ECO:0000250|UniProtKB:Q9Y5S9}.
Interaction partners:
- Partner of Y14 and mago
- Protein mago nashi homolog
- Regulator of nonsense transcripts UPF2
- CASC3/Barentsz eIF4AIII binding protein
- Eukaryotic initiation factor 4A-III homolog
- Nuclear cap-binding protein subunit 2
- Regulator of nonsense transcripts UPF3
- THO complex subunit 4C
- THO complex subunit 4A
- THO complex subunit 4B
Sequence:
MANIESEAVDFEPEEDDLMDEEGTAIDGADVSPRAGHPRLKSAIAGANGESAKKTKGRGFREEKDSDRQRRLSSRDFESLGSDGRPGPQRSVEGWIILVSGVHEETQEEDITNAFGDFGEIKNLNLNLDRRSGYVKGYALIEYEKKEEAQSAISAMNGAELLTQNVSVDWAFSSGPSGGESYRRKNSRYGRSQRSRSPRRRY
Protein: SH2 domain-containing protein (Q54JS2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MESKNDIKNSSNGNVTLSIDTLTITNISLSNNNSNNSNNSNSINSNSNNSNSNNSNNNNHHQNNNNSRNHNILSTSTPSTHNFVGSPSSSTFFNPLHNSTGSSLSFFNGTQHFTHNHHGHMNGFGNSDLVARTKQEDNYSMAKVYLNNKLTFNNHGLGRVDFNMKSEDLDQPWFHKEATRDVAITLLNNKPTGSFLIRPSSQAGSYAMSWMKNGNEIGHNLIYGLCPGYSLKQNSTTDRFWSLQKLVEDCDYLKLPIQVSQTTKNIAKHSNARTNAEVVGRIVERVSSNDPTFTELSWSLCIIGENTNESSDHCQKRTRVKFGDEEYTAPEILPLNGNSLSLICQGLHNNTHTKSLYINGHEGYLRMSFIPNLMDSDAAAIATLITENKSLTLLNLNVNQISDNGTKLIAEALKYNKTLKYISLSYNFIGKDGLVAISEAIRYNKSIDFIDVSNQLFKKRNSINLIHLDTERTLMALIEDTMKRKCELFGMSYKFLDMSQTIHNNNSNNNSNNNNNNSNNNINNINHNSNSNSSFGINCGASQSKLPYFHGYLTKMGAEKRINALSKGKVGSFLFYLNYYIPNCIFLAILVQKGDNPAEIEHKMIHRVHFGYRFVSSGLSSIEQDLRDEILEEEQLYNFQLNNQTYNNTITHSNSYIYSYRHRPRRTGCGVVIPTLFEFCAWILASHPQYQDILDAFEKMGGISERFKDIRDLVPLWGARDVIPIISLDSSKHNISRKGVFPTLLQLYKLNRSKLTNPITTEQYQNYRTLLKQQQQQQQQQQQQQQQLQQQEQQQQQQLTNTINDLNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTENSLVFSSQ
Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase 5 (EC 2.4.1.109) (P52867)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33775}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichyl-phosphate-mannose--protein mannosyltransferase 3
- Dolichyl-phosphate-mannose--protein mannosyltransferase 2
- Probable alpha-1,6-mannosyltransferase MNN10
- Mannan polymerase complexes subunit MNN9
- Mannan polymerase I complex VAN1 subunit
- Dolichyl-phosphate-mannose--protein mannosyltransferase 1
- Putative glycosyltransferase HOC1
- Mannan polymerase II complex ANP1 subunit
- Dolichyl-phosphate-mannose--protein mannosyltransferase 4
- Probable alpha-1,6-mannosyltransferase MNN11
Sequence:
MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVRLHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLYPHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFMFYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWLGSWDFYCNSLLLSDSHYELNAES
Protein: Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) (O60602)
Organism: Homo sapiens (Human)
Function: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24778236}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 4
- Toll-like receptor 2
- Nuclear factor NF-kappa-B p105 subunit
- TNF receptor-associated factor 6
- Transcription factor p65
- Toll/interleukin-1 receptor domain-containing adapter protein
- Interleukin-1 receptor-associated kinase 1
- High mobility group protein B1
- Lymphocyte antigen 96
Sequence:
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS
Protein: Zinc finger protein 746 (Q3U133)
Organism: Mus musculus (Mouse)
Function: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes. {ECO:0000250}.
Interaction partners:
- Transcription intermediary factor 1-beta
- E3 ubiquitin-protein ligase parkin
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Sequence:
MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFSNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEVPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCTWRRTGPKVPEVPVDPSPGSGAPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQADLPPHHPSSACSDGTLKLNTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFAPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPTRPERDIGELSPAIAQEEAPAGDWLFGGVRWGWNFRCKPPVGLNPRTVPEGLPFSSPDNGEAILDPSQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGLSDGAATGAASTTTGGGGGGSGGGGGSSGGGSSARDSSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHPAVAKAPAHGQPLPPLPAPPDPFKSPAAKGPMASTDLVTDWTCGLSVLGPSDGGGDL
Protein: Mitochondrial distribution and morphology protein 30 (Q05930)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.
Subcellular location: Cytoplasm. Mitochondrion.
Interaction partners:
- Mitofusin FZO1
- Suppressor of kinetochore protein 1
- Dynamin-related protein DNM1
- Ubiquitin carboxyl-terminal hydrolase 2
- Mitochondrial F-box protein MFB1
- Ubiquitin carboxyl-terminal hydrolase 12
- E3 ubiquitin-protein ligase RSP5
- Mitochondrial fusion and transport protein UGO1
- Dynamin-like GTPase MGM1, mitochondrial
- Cell division control protein 53
Sequence:
MTKRRNLFMVGSSFTIDHLPPEIWLCISKLVGTSDLHNLCLINRRLYLTITSDEIWKRRCYDRWINRESLDILTGNDYDSIPVSQWYSYYLRRAKWENKIFCLLWGLTEETNPQHFREKYLHILQFRHYKLATFLHRIIKQGYIPDKRPLDLITYANYLLKNVRHKYVFPLFYPTNAAELKNLNNMASRDAEMIYLRLSAIDTSFDDLLDAREFILNGICSDLLQKYKKIEEFLKLRPVTRVSKLISISTDYLDCFTQPHDSVGQTNDRATGRELHREDFMLLRVYSREGRGYKTIILAIIQAITKRYNVDSYLARDHLVVSEPDFPDGRAFVTVNEDFQPYIFDKEDLLSVWSNNFHNAENFESTVLPALLEPISIQHLLTEFFRELLRCKPRPFEGYPNRAHGLRDMFPYGKVEVPRDVTMYFAFIYDLFDGMFESGMTSLRGQMLRDLLNYVNANNFGDLNIIIGQNALKEPNDCWSNKRDYVLLDDNNKIGYFYTDIETEDTLCALNQYEVDGKVFITTIDILGDIRVRLAEGLTPFQGDNDKLWESFSSVVPRTDWGLFFKGYDKERRRMQLNPYIEEKLSNLANDEQPLHNL
Protein: Peptidyl-prolyl cis-trans isomerase FKBP53 (PPIase FKBP53) (EC 5.2.1.8) (FK506-binding protein 53) (AtFKBP53) (Immunophilin FKBP53) (Rotamase) (Q93ZG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Histone chaperone possibly involved in H3/H4 deposition to the nucleosome. Associates with 18S rDNA chromatin and negatively regulates the level of its expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:20142844}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase FKBP17-3, chloroplastic
- Ribosome production factor 2 homolog
- Ubinuclein-1
- Ribosome biogenesis protein BOP1 homolog
Sequence:
MGFWGLEVKPGKPQAYNPKNEQGKIHVTQATLGTGLSKEKSVIQCSIGDKAPIALCSLLPNKIECCPLNLEFDDDDEPVEFTVTGDRSIHLSGFLEYYQDDEDDYEHDEDDSDGIDVGESEEDDSCEYDSEEDEQLDEFEDFLDSNLERYRNAAAPKSGVIIEEIEDEEKPAKDNKAKQTKKKSQASEGENAKKQIVAIEGAHVPVLESEDEDEDGLPIPKGKSSEVENASGEKMVVDNDEQGSNKKRKAKAAEQDDGQESANKSKKKKNQKEKKKGENVLNEEAGQVQTGNVLKKQDISQISSNTKAQDGTANNAMSESSKTPDKSAEKKTKNKKKKKPSDEAAEISGTVEKQTPADSKSSQVRTYPNGLIVEELSMGKPNGKRADPGKTVSVRYIGKLQKNGKIFDSNIGKSPFKFRLGIGSVIKGWDVGVNGMRVGDKRKLTIPPSMGYGVKGAGGQIPPNSWLTFDVELINVQ
Protein: Uncharacterized protein (Q57ZN4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYVFSPAPQQKDPGGGVEVKVKSSDTGNGGQCSDAQWKVNFLSCLRGPAQTCRLLTCLSNTIVDVASGQTKVGKTANSEQKCISSSATDPVVQESYLTELCKYLAPEASSSDTGASTSAKNETSLLCVPKGEKGRMLYSTFLRMAEIPYWRQTLLGPLLRCWCSEGCDELGGTFLLEAIVNAIERELCSLNMLEQRHPIPEDASGGPELWDLSKYDKAEARQYEVLINELEGVVRGAGSFRGICIVMDCIIRNSIQRLVEGVHYVVCGMSARGGALPTGGVRMNEEVVRVVDSVVALVWREIGSFFQRCEVDVEAALSETQWLFLMLLITGYKGAHALLAAPPSVSSSSASSNTDTATTTTITDRIHLRARRMFFEKLQSNLRDYLSMRLLAGGDPASNSFASVHTVTCHQPFFWRCTLEAESAPGHLPPALSVNIVIKEWVKKEAATAWGNAVRVVRCFVHGQMAVEDVPLTAVPAVSESVISSIQRCHRQLVEQHIEHLSASQKYFFSAGKRPREDEGKHAMDGGSTWLSYMVEFFFCVYHPSCFSILSPVKQGEFVSLLRQLHDMILYKGHDALEGSIASLLPGEKASEVKLRDELMQWHTQYVHTRVVNALRENSFLVMCLLHGVFALFSRAGRTNIQGHEVLKCTLLPILSILCSPQGEGEGGEEDEEDVTAVEENATTDETDAFFVDRQERQQCMILLVTSGFMSIPWNLRGLRIRLLLFGILGTRLRDSFGSEGAASELYQLLSEVVSGQRTPEDIASEIFGDCTGDPFLSLLVSEREDTDGGTVVDAMEDILRRDVPVQFPAPCGTLLLMSVFRTLSQELLRLRTEWEQQIKLLSESESDYLGRQATFCTTEDIVVFRILVRVIHHMVFGFQVQPLGLLRLWISFLVHLFAFIVPPLTEDDELILLAPHVLERRLHKQQEDNDRKLNDSAGAISSSNFRRSANESSQGELRAALGELLADLVLMPLLDGEVAKQCPAAIPSHPGSRMWVKQNIRRSADILLLQRVLPAQVLEELCLALGVNVSAMNDKGPNGVRATRQVGGGVGKSFLGVLGVFAFCQRLDHFVVPGSVSDDGVALHLQALWHAVEVGYASSAV