wanglab/gogpt-training-data huggingface dataset:
Protein: Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) (Q9BWT7)
Organism: Homo sapiens (Human)
Function: Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- B-cell lymphoma/leukemia 10
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
- Caspase recruitment domain-containing protein 14
- Protein kinase C theta type
- Caspase recruitment domain-containing protein 11
- Protein kinase C beta type
- NF-kappa-B essential modulator
- Transmembrane protein 43
Sequence:
MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA
Protein: Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (P53033)
Organism: Gallus gallus (Chicken)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication factor C subunit 4
- Uncharacterized protein.
- Replication factor C subunit 5.
- Replication factor C subunit 3
- Replication factor C subunit 1.
- Proliferating cell nuclear antigen
- Checkpoint protein
- Cell cycle checkpoint control protein RAD9A
- AAA domain-containing protein.
- AAA domain-containing protein.
Sequence:
MEEEEVLEVVEDEKAGPAAAEKRGPTDTLGSAPAASGHYELPWVEKYRPLKLCEVVGNEDTVSRLEVFAKEGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDSQILARLLKIVEKEDVPYTDDGLEAIIFTAQGDMRQALNNLQSTYSGFGFINSENVFKVCDEPHPLLVKEMIQHCINANIDEAYKILAHLWRLGYSPEDVIGNIFRVCKTFQMPEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTAAPAAS
Protein: Tetraspanin (Q6P0W1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
Sequence:
MDGCAQISKCFLVLFNIIYGLLGFSLVSLGLWLRFGAETRGFFDIDLNTSQFNIGVMVLMVSGALMLLVSVIGNCGVCCSSKGSLSVFAGLLSVLILIEISAGVMVIMQSGKVSDELVEFYSTVYAQYLNTRSASQAVSLKMFHDAFDCCGVGGSIELFVRDTCPDGNILKQLTFPSCPSVIKDVFNSNAPRLLGGFLGIAGVMMLALVCSCVLMRSVSASRASPPAYVLLSSTPSLLQPPTAQPV
Protein: RNA-binding protein fxr1 (XtFxr1p) (Q5BJ56)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: RNA-binding protein. Binds poly(G) and poly(U) but not poly(A) or poly(C). Regulates somite formation, probably by regulating gene expression (By similarity).
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q61584}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P51114}. Cytoplasm {ECO:0000269|PubMed:15968590}. Nucleus {ECO:0000269|PubMed:15968590}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Nuclear very early in embryonic development (at two hours post-fertilization), becoming cytoplasmic in later embryonic stages through to adulthood (PubMed:15968590). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:15968590}.
Interaction partners:
- Fragile X messenger ribonucleoprotein 1 homolog
- Cytoplasmic FMR1-interacting protein
- Cytoplasmic FMR1-interacting protein
- Protein argonaute-2
- Tudor domain-containing protein 3
Sequence:
MEDLAVEVRGSNGAYYKGFVKDVHEDSLTVVFENNWQPERQVPFHEVRMPPLPDIKKEITEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPGNQNKSVTKSSFFKCTVDVPEDLREPCSNENVHKEFKKAVGACRVYFHAETNQLIILSACESTVKRVTILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGITAIELDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNETKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSSRGTEKEKGYATDESTASSVRGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKEELSDWSLAGEDERESRQQRDSRRRPGGRGRSGSAGRGRGGSRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHNTNRRRRSRRRRTDEDSSLMDGMTESDNASVNENGLDDSEQKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPKEPLAKGKKEKVKDVIEEHGPSEKVINGPRAASADKALKPQTTERNKASCQDGSKQEAILNGVS
Protein: Polyadenylate-binding protein 1 (H0YB75)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
IRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
Protein: Protein cornichon (P49858)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16396907}; Multi-pass membrane protein {ECO:0000269|PubMed:16396907}.
Interaction partners:
- Glutamate receptor IB, isoform B
- Pre-mRNA-processing factor 19
- Glutamate receptor 1
- small monomeric GTPase
- Protein gurken
Sequence:
MAFNFTAFTYIVALIGDAFLIFFAIFHVIAFDELKTDYKNPIDQCNSLNPLVLPEYLLHIFLNLLFLFCGEWFSLCINIPLIAYHIWRYKNRPVMSGPGLYDPTTVLKTDTLYRNMREGWIKLAVYLISFFYYIYGMVYSLIST
Protein: Cytoplasmic 60S subunit biogenesis factor REI1 homolog 2 (Protein REI1-LIKE 2) (pre-60S factor REI1 homolog 2) (Q9ZQ18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity). Can complement the growth defect of a yeast mutant lacking REI1. Required for leaf growth under cold temperature conditions.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P38344}.
Interaction partners:
- 60S ribosomal export protein NMD3
- Eukaryotic translation initiation factor 6-2
- DNAJ protein JJJ1 homolog
- Large ribosomal subunit protein eL24z
- Ribosome assembly factor mrt4
- Eukaryotic translation initiation factor 6-1
- Large ribosomal subunit protein eL24y
- ERBB-3 BINDING PROTEIN 1
- Probable ribosome biogenesis protein RLP24
- Large ribosomal subunit protein uL3y
Sequence:
MSGLACNSCNKDFEDDAEQKFHYKSEWHRYNLKRKIAGVPGVTEALFEARQAAIAQEKVKAVEAPMLYSCGICNKGYRSSKAHEQHLKSKSHVLKASTSTGEEDKAIIKQLPPRRVEKNNTAQLKGSIEEEESEDEWIEVDSDEDLDAEMNEDGEEEDMDEDGIEFELDPACCLMCDKKHKTIEKCMVHMHKFHGFFIPDIEYLKDPKGFLTYLGLKVKRDFVCLYCNELCHPFSSLEAVRKHMDAKGHCKVHYGDGGDEEDAELEEFYDYSSSYVNGDENQMVVSGESVNTVELFGGSELVITKRTDNKVTSRTLGSREFMRYYKQKPAPSSQKHIVNSLTSRYKMMGLATVQSKEAIVRMKVMREMNKRGAKSSVRLGMKSNVIRNLPNNVTY
Protein: Red-sensitive opsin (Red cone photoreceptor pigment) (O12948)
Organism: Xenopus laevis (African clawed frog)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MASQLNEAIFAARRRNDDDDTTRSSVFTYTNSNNTRGPFEGPNYHIAPRWVYNLTSIWMIFVVFASVFTNGLVIVATLKFKKLRHPLNWILVNMAIADLGETVIASTISVFNQIFGYFILGHPMCVLEGFTVSTCGITALWSLTVIAWERWFVVCKPFGNIKFDEKLAATGIIFSWVWSAGWCAPPMFGWSRFWPHGLKTSCGPDVFSGSSDPGVQSYMLVLMITCCIIPLAIIILCYLHVWWTIRQVAQQQKESESTQKAEREVSRMVVVMIVAYIFCWGPYTFFACFAAFSPGYSFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIYQMFGKKVDDGSEVSSTSRTEVSSVSNSSVSPA
Protein: Variant surface glycoprotein (VSG), putative (Q38CQ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MFSTPNTAPCSLQASRNNTRRNTRQKMTLSCLLLAALAIMLPLSAEKAAAAAGDSLKAAAWQPVCQLAEALNKVPSNSKLRLRALITTTQGQRLAAAKLGVYALLAEEAQESKAAVVLAAWYSRLADLNDNLLKTTLVDTTIDAVASSIYVKGRADEALNILAQAKTTSNGCLLTDDSGTLAAHGPAKIGETPCSRKLEPPVLDTYENLDEVMDANGWKSSHATTAKADLAGSGGDKTCKLLTVDGAGFGAAKLDADLELGGGLWVVNKDDKQIKTVEIKKGSSTATKTGNMYQHAWHKLQALDSAEQETKPNATEGAEATSELQAAITNTLHNGQEGAAGQPETAVLAVFPKPTGTSINNLLHRANEAQLPEKIAGVNAKTKLRSIVDTHKFQQIEGALILQLKNENTKLKTSKSDEQKDDESTKNQIHCNSIAEVEKCNADPKCSYETKTDGTKKCKFNSTKAKEKGIPVTQTQTGGTTGDGVKCSDHKDQSTCEKANEGKTTKVCGWRSGKDNEDEKDKVKCRDSSFLLSKQFTLSVVSAAFVALLF
Protein: Protein-lysine N-methyltransferase EFM4 (EC 2.1.1.-) (Elongation factor methyltransferase 4) (Secretion and early endocytosis protein 1) (P40516)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-316'. May play a role in intracellular transport.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein-lysine N-methyltransferase EFM2
- Elongation factor 1-alpha
- Protein-lysine N-methyltransferase EFM5
- Protein-lysine N-methyltransferase EFM6
- Protein-lysine N-methyltransferase EFM1
- Protein N-terminal and lysine N-methyltransferase EFM7
- Protein-lysine N-methyltransferase EFM3
- Histidine protein methyltransferase 1
- Alpha N-terminal protein methyltransferase 1
- Ribosomal lysine N-methyltransferase 1
Sequence:
MQGTADLSTSKLGTKKYWDELYALELENFRRNPQDTGDCWFSDSDAEQKMIDFLVDNIGAYRISENASVVDLGTGNGHMLFELHQTEFQGKLVGIDYSEESVKLASNIAEATGVDNFISFQQADIFSGDWKPGKYDIVLDKGTLDAISLSGMKINGKLDVVDVYAGVVERILKKDGIFLITSCNFTQDELVKIIETDNLKMWKTIKYPVFQFGGVQGATICSVAFVKQN
Protein: DUP240 protein DFP2 (DUP240 family protein 2) (P39549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12101299}. Membrane {ECO:0000269|PubMed:12101299}; Peripheral membrane protein {ECO:0000269|PubMed:12101299}. Note=Punctate pattern.
Interaction partners:
- Protein-toxin resistance protein KTD1
Sequence:
MNKYLFDHKIWSTPYYFYCEEDCHRLFLSFIEGRTFEKPTSNAEENVQETEAGESFTLNPGEDFQNCFPRQRIL
Protein: Potassium voltage-gated channel subfamily Q member 5 (A0A8I6AWB8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPRHHAGGEEGGAAGLWVRSGAAAAAGGGRPGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEAASRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLTSFQIPPFECEQTSDYQSPVESKDLSSSAQNSGCLSRSASANISRGLQFILTPNEFSAQTFYALSPTMHSQTTQVPMSQNDGSSVVATNNLANQISAAPKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPPGVHESISDVTTCLVASKENVQFAQSNLTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSGSESSGSRGSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRSRSSQNICKTGDSTDALSLPHVKLN
Protein: C-X-C motif chemokine (Q8K4B1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU361149}.
Interaction partners:
- C-X-C chemokine receptor type 3
- C-X-C motif chemokine 10
- C-C motif chemokine 5
- Stromal cell-derived factor 1
- C-C chemokine receptor type 5
- C-C motif chemokine 2
- C-X-C motif chemokine
- Platelet factor 4
- C-X-C motif chemokine ligand 13
- C-X-C chemokine receptor type 4
Sequence:
MKSVALFLMGIIFLDHCGVRGTLVIRNQRCSCISTSQGTFHYKSLKDLKQFAPSPNCNKTEIIATLKNGDQTCLDPDSARVKKLMKEWEKKISQKKKQKRGKNHQRSKKTRKAKTPHHPESKKTA
Protein: Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) (O95696)
Organism: Homo sapiens (Human)
Function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}. Note=Localizes to transcription start sites. {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}.
Interaction partners:
- Histone acetyltransferase KAT7
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT6A
- Histone acetyltransferase KAT6B
- Inhibitor of growth protein 5
- Bromodomain and PHD finger-containing protein 3
- Inhibitor of growth protein 4
- Peregrin
- Histone H3.3
- Histone H3.1
Sequence:
MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPAVSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRELLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALGPEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID
Protein: Sister chromatid cohesion protein DCC1 (Q57UZ8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Chromosome transmission fidelity protein 18 homolog
- Replication factor C, subunit 5, putative
- DNA polymerase epsilon catalytic subunit
- Replication factor C, subunit 3, putative
- Replication factor C, subunit 4, putative
- Replication factor C, subunit 2, putative
- DNA polymerase
- DNA primase large subunit
- DNA primase
- DNA polymerase
Sequence:
MARVTLREDFDDCAADYRILSVSADHFKEITCKVAACKQTGEEMGKINETHHEATTLMTMKGGSQLLLCDDERTFRVRRVEYSNTLLLAEAKAAKMHDTNGIIESDNASDAGEGREHVVVCSSERVFEVKPSVAYNDISQHLLESPLTLKELDTLGTVERSDENVEYIKREELENGTSSSAQRFYTFPQLVALNRSSARELAVILSDMGAVVFNGYVRLLKPALMREALRASLNFFDAYDTMSWEGVMEQLCPSVYPHIVLRAVRAAYGNATASGETPRGMAAFLQVPKVLQALAASVLLADDAEQNTQFTEAELQDKKLSKSVNRRGSLFPELDFDIFYDSWTSSIPSSLFADGTLPSQSDRNALLKFLYGSVIVVRNAEGDSHVGARAVWAPSNVLSTDVSLRTRQLFEIRPGRWEAEELRAYVAPLLDPGVAFDHIIVRYAKEYRVPGRPVMYGNLS
Protein: Probable ADP-ribose 1''-phosphate phosphatase YML087W (EC 3.1.3.84) (Q04299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate.
Interaction partners:
- Protein PET20, mitochondrial
- ADP-ribose 1''-phosphate phosphatase
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Sequence:
MTGSLNRHSLLNGVKKMRIILCDTNEVVTNLWQESIPHAYIQNDKYLCIHHGHLQSLMDSMRKGDAIHHGHSYAIVSPGNSYGYLGGGFDKALYNYFGGKPFETWFRNQLGGRYHTVGSATVVDLQRCLEEKTIECRDGIRYIIHVPTVVAPSAPIFNPQNPLKTGFEPVFNAMWNALMHSPKDIDGLIIPGLCTGYAGVPPIISCKSMAFALRLYMAGDHISKELKNVLIMYYLQYPFEPFFPESCKIECQKLGIDIEMLKSFNVEKDAIELLIPRRILTLDL
Protein: Homeobox protein Meis3 (Meis1-related protein 2) (Q99687)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P97368}.
Interaction partners:
- Pre-B-cell leukemia transcription factor 4
- Pre-B-cell leukemia transcription factor 2
Sequence:
MARRYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPPQPLPPGLDSDGLKREKDEIYGHPLFPLLALVFEKCELATCSPRDGAGAGLGTPPGGDVCSSDSFNEDIAAFAKQVRSERPLFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIEDRDGGCREDFEDYPASCPSLPDQNNMWIRDHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGLDTSVASPSSGGEDEDLDQERRRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQPIGGYTETQPHVAVRPPGSVGMSLNLEGEWHYL
Protein: DNA replication fork-blocking protein FOB1 (O13329)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for replication fork blocking activity at the replication fork barrier (RFB) site in rDNA and for recombination hot-spot (HOT1) activity, regulating the recombination rate and the number of rDNA copies. Binds directly to two separated sequences in the RFB.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10230397, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Nucleolar protein NET1
- NAD-dependent histone deacetylase SIR2
- Sporulation-specific protein 12
- Tyrosine-protein phosphatase CDC14
- Topoisomerase 1-associated factor 2
- ATP-dependent DNA helicase RRM3
- Monopolin complex subunit CSM1
- Monopolin complex subunit LRS4
- DNA topoisomerase 1
- Topoisomerase 1-associated factor 1
Sequence:
MTKPRYNDVLFDDDDSVPSESVTRKSQRRKATSPGESRESSKDRLLILPSMGESYTEYVDSYLNLELLERGERETPIFLESLTRQLTQKIYELIKTKSLTADTLQQISDKYDGVVAENKLLFLQRQYYVDDEGNVRDGRNNDKIYCEPKHVYDMVMATHLMNKHLRGKTLHSFLFSHFANISHAIIDWVQQFCSKCNKKGKIKPLKEYKRPDMYDKLLPMERIHIEVFEPFNGEAIEGKYSYVLLCRDYRSSFMWLLPLKSTKFKHLIPVVSSLFLTFARVPIFVTSSTLDKDDLYDICEEIASKYGLRIGLGLKSSARFHTGGILCIQYALNSYKKECLADWGKCLRYGPYRFNRRRNKRTKRKPVQVLLSEVPGHNAKFETKRERVIENTYSRNMFKMAGGKGLIYLEDVNTFALANEADNSCNNNGILHNNNIGNDNFEEEVQKQFDLTEKNYIDEYDDLAHDSSEGEFEPNTLTPEEKPPHNVDEDRIESTGVAAPMQGTEEPEKGDQKESDGASQVDQSVEITRPETSYYQTLESPSTKRQKLDQQGNGDQTRDFGTSMEL
Protein: Junction adhesion molecule like (E9PR26)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEGEKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQAF
Protein: Intrastrand cross-link recognition protein (Structure-specific recognition protein) (SSRP) (P33417)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Activate the expression of the COX5B gene.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA damage response protein kinase DUN1
- Repressor ROX1
- Non-histone chromosomal protein 6B
- Non-histone chromosomal protein 6A
- Damage-regulated import facilitator 1
Sequence:
MNTGISPKQDDASNSNLLNIGQDHSLQYQGLEHNDSQYRDASHQTPHQYLNQFQAQPQQQQQQQQQQQQQQQQAPYQGHFQQSPQQQQQNVYYPLPPQSLTQPTSQSQQQQQQQQQQQYANSNSNSNNNVNVNALPQDFGYMQQTGSGQNYPTINQQQFSEFYNSFLSHLTQKQTNPSVTGTGASSNNNSNNNNVSSGNNSTSSNPAQLAASQLNPATAAAAAANNAAGPASYLSQLPQVQRYYPNNMNALSSLLDPSSAGNAAGNANTATHPGLLPPNLQPQLTHHQQQMQQQLQLQQQQQLQQQQQLQQQHQLQQQQQLQQQHHHLQQQQQQQQHPVVKKLSSTQSRIERRKQLKKQGPKRPSSAYFLFSMSIRNELLQQFPEAKVPELSKLASARWKELTDDQKKPFYEEFRTNWEKYRVVRDAYEKTLPPKRPSGPFIQFTQEIRPTVVKENPDKGLIEITKIIGERWRELDPAKKAEYTETYKKRLKEWESCYPDENDPNGNPTGHSHKAMNMNLNMDTKIMENQDSIEHITANAIDSVTGSNSNSTNPNTPVSPPISLQQQPLQQQQQQQQQQQHMLLADPTTNGSIIKNE
Protein: Arginine kinase Scy s 2 (AK) (EC 2.7.3.3) (allergen Scy s 2) (C9EIP1)
Organism: Scylla serrata (Mud crab)
Function: Catalyzes the reversible transfer of high energy ATP gamma-phosphate group to L-arginine.
Interaction partners:
Sequence:
MADAAVIEKLEEGFKKLEAATDCKSLLKKYLTKSVFDQLKGKKTSLGATLLDVIQSGVENLDSGVGVYAPDAEAYTLFAPLFDPIIEDYHKGFKQTDKHPNKDFGDVNQFVNVDPDGKFVISTRVRCGRSMEGYPFNPCLTEAQYKEMESKVSSTLSNLEGELKGTYYPLTGMTKDVQQKLIDDHFLFKEGDRFLQAANACRYWPTGRGIYHNDNKTFLVWCNEEDHLRIISMQMGGDLGQVYRRLVSAVNEIEKRVPFSHHDRLGFLTFCPTNLGTTVRASVHIKLPKLAANREKLEEVAGKYSLQVRGTRGEHTEAEGGVYDISNKRRMGLTEFQAVKEMQDGILELIKMEKEM
Protein: N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] (P53397)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Subcellular location: Nucleus.
Interaction partners:
- Endonuclease III homolog 2 lyase 2)
- Apurinic-apyrimidinic endonuclease 1
- DNA mismatch repair protein MSH6
- Endonuclease III homolog 1 lyase 1)
- DNA-
- DNA polymerase eta
- Uracil-DNA glycosylase
- DNA ligase 1
- Flap endonuclease 1
- DNA mismatch repair protein MSH3
Sequence:
MSYKFGKLAINKSELCLANVLQAGQSFRWIWDEKLNQYSTTMKIGQQEKYSVVILRQDEENEILEFVAVGDCGNQDALKTHLMKYFRLDVSLKHLFDNVWIPSDKAFAKLSPQGIRILAQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTIDGVAYHSFPTSEELTSRATEAKLRELGFGYRAKYIIETARKLVNDKAEANITSDTTYLQSICKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQISANKNHLKELRTKYNALPISRKKINLELDHIRLMLFKKWGSYAGWAQGVLFSKEIGGTSGSTTTGTIKKRKWDMIKETEAIVTKQMKLKVELSDLHIKEAKID