wanglab/gogpt-training-data huggingface dataset:
Protein: Repressor of RNA polymerase III transcription MAF1 (Q7PL26)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037240}.
Interaction partners:
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC3
- LD32951p
- DNA-directed RNA polymerase III subunit RPC6
- FI04119p
- DNA-directed RNA polymerase III subunit
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase I subunit RPA1
- Uncharacterized protein, isoform B
Sequence:
MKLLESSRFEAINNALSIQTSGITIFGRIESYSCKMVAAEKVLYKRFTADSHGHDLQALSPPQTLADFSPNFRRNNSQSGDEGITLCDTISRKTLFYLIATLNASFEPDYDFSEAKSHEFSKEPSLQWVMNSIHANLSALAGDKYQAIRQPLWSAVDDEVILSECDIYSYNPDLSCDPFGEPGCLWSFNYFFYNKKLKRIVFFTSRAVNSLYAGETLPFSMEEEVY
Protein: Encapsulin nanocompartment cargo protein EncB (Q1D6H3)
Organism: Myxococcus xanthus (strain DK1622)
Function: Cargo protein of a type 1 encapsulin nanocompartment. May help nucleate Fe atoms in the interior of the encapsulin nanocompartment (Probable). Present in about 36 copies/encapsulin nanocompartment.
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:25024436}. Note=Probably lies against the interior face of the nanocompartment. {ECO:0000305|PubMed:25024436}.
Interaction partners:
- Type 1 encapsulin shell protein EncA
- Encapsulin nanocompartment cargo protein EncD
- Encapsulin nanocompartment cargo protein EncC
Sequence:
MAGPPDSDLDDVARIRLVLARELETINEYEAYARASSNPEVRAFFQHLAAEEKEHVSEAVHMLRMLDSGQNDHFAKPFVPGHFQAAEAPAPATVHVPTPDGPAFSVNGRNGRLPSEPPTSLPPQRLLYGLPAPPPAVESHPLTVGSLRRGGGGSGSGR
Protein: Serine protease inhibitor (Serpin-3) (Q9U1I6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKYLCLLLLATSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAAKFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKSDFHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLININVHLRLPKFKIEFSARLEQVLIAVGIQDAFKTSADFNDLVANSGAHVGGVVHKAFLDVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAENIYFQGHFVNPEL
Protein: At1g55140 (Ribonuclease III family protein) (Q6NQK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- YacP-like NYN domain protein
- Cysteine--tRNA ligase, chloroplastic/mitochondrial
- Cysteine--tRNA ligase 2, cytoplasmic
- Cysteine--tRNA ligase 1, cytoplasmic
- Large ribosomal subunit protein bL28c
- 50S ribosomal protein L33
- Large ribosomal subunit protein uL3c
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL3y
- Large ribosomal subunit protein uL3z
Sequence:
MAILSASSTIVRAALDTQPKLRYNPNAPRNVKKNSNLSSFVPPSSPSSSSPATNLSVSVSDLLKRPASKDIGDGFDDTCVGYEKWFPSPPKVEKPRSVFNAASLAYIGDSIYEIYARRHFLFPPLSIEEYNDRVRAVVRCEAQYALLQKLVDDDFLTKDERDILRWGKNVGSVKTRSTRRAGVAVYNKASSLETLIGYLYLSNGKRLEEMMQKLGFSSGSSTERMVKEAGSNKPSFK
Protein: RNA polymerase II C-terminal domain phosphatase-like 3 (FCP-like 3) (EC 3.1.3.16) (Carboxyl-terminal phosphatase-like 3) (AtCPL3) (CTD phosphatase-like 3) (Q8LL04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Completely dephosphorylates 'Ser-2', and partially 'Ser-5' and 'Ser-7' of the heptad repeats YSPTSPS in the C-terminal domain (CTD) of the largest RNA polymerase II subunit (RPB1). Involved in defense response. Acts as negative regulator of immune gene expression and immunity to pathogen infections. Preferentially dephosphorylates 'Ser-2' of RNA polymerase II CTD. This counterregulates the MAP kinase (MAPK) or cyclin-dependent kinase C (CDKC)-mediated phosphorylation of CTD in response to pathogens and upon perception of microbe-associated molecular patterns (MAMPs). MAPKs phosphorylate and activate CDKCs, which are CTD kinases that positively regulate plant innate immunity. Acts as negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated signaling pathway and cold resistance. Acts as post-transcriptional gene silencing (PTGS) suppressor.
Subcellular location: Nucleus {ECO:0000269|PubMed:16905668, ECO:0000269|PubMed:25464831}.
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- Tryptophan/tyrosine permease
- Transmembrane protein
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit 4
- Defensin-like protein 24
- RNA polymerase II C-terminal domain phosphatase-like 1
- RNA polymerase II C-terminal domain phosphatase-like 2
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases II, IV and V subunit 3
Sequence:
MLVARSGCSRTLIRMGNDENLMVMVDVEEGEIPDSVNTEIEVKHKSTTTTADVGGDVDVGVVAGGRGGGGGGSNGNSRVWTMEELISQYPAYRPYANSGLSNLAWARAVQNKPFNEGLVMDYEPRESDKIVIEDSDDEKEEGELEEGEIDLVDNASDDNLVEKDTESVVLISADKVEDDRILKERDLEKKVKLIRGVLESTSLVEAQTGFEGVCSRILGALESLRELVSDNDDFPKRDTLVQLSFASLQTINYVFCSMNNISKERNKETMSRLLTLVNDHFSQFLSFNQKNEIETMNQDLSRSAIAVFAGTSSEENVNQMTQPSNGDSFLAKKLTSESTHRGAAYLRSRLPMLPLLDLHKDHDADSLPSPTRETTPSLPVNGRHTMVRPGFPVGRESQTTEGAKVYSYESDARKAVSTYQQKFGLNSVFKTDDLPSPTPSGEPNDGNGDVGGEVSSSVVKSSNPGSHLIYGQDVPLPSNFNSRSMPVANSVSSTVPPHHLSIHAISAPTASDQTVKPSAKSRDPRLRLAKPDAANVTIYSYSSGDARNLSKVELSADLVNPRKQKAADEFLIDGPAWKRQKSDTDAPKAAGTGGWLEDTESSGLLKLESKPRLIENGVTSMTSSVMPTSAVSVSQKVRTASTDTASLQSLLKDIAVNPTMLLNLLKMGERQKVPEKAIQKPMDPRRAAQLPGSSVQPGVSTPLSIPASNALAANSLNSGVLQDSSQNAPAAESGSIRMKPRDPRRILHGSTLQRTDSSMEKQTKVNDPSTLGTLTMKGKAEDLETPPQLDPRQNISQNGTSKMKISGELLSGKTPDFSTQFTKNLKSIADMVVVSQQLGNPPASMHSVQLKTERDVKHNPSNPNAQDEDVSVSAASVTAAAGPTRSMNSWGDVEHLFEGYDDIQRVAIQRERVRRLEEQNKMFASQKLSLVLDIDHTLLNSAKFNEVESRHEEILRKKEEQDREKPYRHLFRFLHMGMWTKLRPGIWNFLEKASKLYELHLYTMGNKLYATEMAKLLDPKGVLFNGRVISKGDDGDPLDGDERVPKSKDLEGVMGMESSVVIIDDSVRVWPQHKMNLIAVERYLYFPCSRRQFGLLGPSLLELDRDEVPEEGTLASSLAVIEKIHQNFFSHTSLDEVDVRNILASEQRKILAGCRIVFSRIIPVGEAKPHLHPLWQTAEQFGAVCTTQVDEHVTHVVTNSLGTDKVNWALTRGRFVVHPGWVEASAFLYQRANENLYAINP
Protein: Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4) (Q99NE9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Homeobox protein Meis3
- Homeobox protein Meis2
- Homeobox protein Hox-B1
- Cartilage intermediate layer protein 2
Sequence:
MAAPLRPVPPQPAPRRLPTTAPLGHDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKSALFSVLCEIKGKTAVSIQFQEEDPPDAQLLRLDNMLLAEGVSRPEKRGRGAAAGSTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLREQSRVRPVSCREMEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLDARRKRRNFSKQATDVLNEYFYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKNTGKFQEEATMYTGKASTVTKARRPRGQSSCQSTPSPGPCGPLPLTNGSDVVLTLRTLAFLQPPTGGVCLQPLVHSNWQRAAPQPASSPAGESGSFNWDAASN
Protein: Activator protein 4 (Cropped, isoform A) (Cropped, isoform B) (FI04923p) (FI10101p) (Q9V406)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSAVPVAIKTEEVILEHAEYNSAEELDEELQLQLEDSGGENYHIEFASESAHQGSQRRQSSMSGTNTSKGGGGGGSGALSDGDGSGKPLVDSEKRMRREIANSNERRRMQSINAGFQSLRSLLPRHEGEKLSKAAILQQTFQYIVELENQKTQLLTQNSELKRQVGEHEAGGSGDGGGTNSGGNYNDSNASGGNSTAVAIKKRKLTDNVINIQAISDSSDEGLGSMSPEPMTLLTAGGAAATKLSNAATLLAAKELHESKKQLEKERSLRRLLEDELQMIKRQLYSVATAPPGTAVAAASGGSSGAYIPREVIEHTDNFVRSEDLEELGGTVSYVEIDEMTGQQQVVVCSSIEELEADAAAEIITEDQVHEEVILSSNSSTESENEVNVNAIAKAYAEGCTSSAAMLQPILQAAIKATPKVEVERIHEKIVKVKTEKHDLPSMQTAPHYQHSHRQNLETIVQAIRHLEGDHLFADGSGGQEKFGQQQNLQQHHHQMSGVHHQQLQHHRLAQDAPLALTTTGKQHAALAELRPFLQLKSGGNKQVIITAKTAKDSGGLVSTSTSSTAVTPTAIFKVQTTGGHGNGSHLPAGSSTGTIITGSNGSGGAQQLTITTSLKQCRPGVIVAKQLPSS
Protein: RRM domain-containing protein (Q3UZI0)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
IFLSFSKRLALLLTGQAASPQLCPGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAYEDYYYHPPPRMPPPMRGRGRGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQQQRGRGSRGARGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK
Protein: Fructose-bisphosphate aldolase, glycosomal (EC 4.1.2.13) (P07752)
Organism: Trypanosoma brucei brucei
Subcellular location: Glycosome.
Interaction partners:
Sequence:
MSKRVEVLLTQLPAYNRLKTPYEAELIETAKKMTAPGKGLLAADESTGSCSKRFAGIGLSNTAEHRRQYRALMLECEGFEQYISGVILHDETVYQKAKTGETFPQYLRRRGVVPGIKTDCGLEPLVEGAKGEQMTAGLDGYIKRAKKYYAMGCRFCKWRNVYKIQNGTVSEAVVRFNAETLARYAILSQLCGLVPIVEPEVMIDGTHDIETCQRVSQHVWSEVVSALHRHGVVWEGCLLKPNMVVPGAESGLKGHAEQVAEYTVKTLARVIPPALPGVTFLSGGLSEVMASEYLNAMNNCPLPRPWKLTFSYARALQSSAIKRWGGKESGVEAGRRAFMHRAKMNSLAQLGKYNRADDDKDSQSLYVAGNTY
Protein: Hyaluronan mediated motility receptor (Hyaluronan-mediated motility receptor (RHAMM)) (E7EYJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
- SR-related CTD-associated factor 1
- SH3 and PX domain-containing protein 2B isoform X1
- Abnormal spindle-like microcephaly-associated protein
Sequence:
MSFSRAPLKRFNEHVGCAPPPGTYDVKSGDLKGAASFHKAERFKTAPKNVPLPSPSKDVLMSPVRRTMSVDGLADALSSKKDKSSFTLEMKHQRLLEKEIRSLVQQRGEQDRRLLALEEELKKLESKLLVAVREKTGLAANVISLERQLAELKKANEFLKTKVSADITKKKINALSMELIEAKNKLDAKDKELSFLQISSEGKVKVLETDLETAKTTFRVLQDRNKDLEDLHQETRAQNELLENEMDKLHNIIQELREEIKALQSYLDSANEEIQDLRIKLQDKSTMERRVSDAQENLSEVEQKLEKCTAELQECQEALKVKEDEVQRSKQELRDSQNALEEKEKEIEQHAQDLQESQSSLKELEERMKQGDRDLEESWSLVRQQEQELARVKEVLRRTEEELDQRVALMGERCSLLEDERAKMQEEGLRQVEELKAELCSLEESRKTETEAYEKLKEEHCAVTKQLEEEKTHSGSLASLLERLRDDTEAERRQLGEELEDALEELVELEKQEQCSEEAIQQLTLNNQTLEQELKKSCAELQKTCAEMQALEEAHVRAIKKLEEDHTSCLAKLGDVTTDFERTRQALGNQKDHAEAQVHQLVEEINQLKQQLQQDQQKLLSQQEIQDQKQEEQARMLLEVQTKLAQREEELKRAAETHSEELRCLQMDVEQERGEKERAQTQLEKEQKRRQSVEGRSAEASRVRSHVEELEDEVSKLRRLMQEERDAAKHHTVEWQQEKQQLCTQIEEERQDLHRQLAEARLQSTSDSETEHWRNLYEELYAKVKPFQEQLDRFAAERSALLNEKGATQAELNKLADAYANLMGHQNQRQKIKHMVKLKEENLELKQEVSKLRSQVGKQKQELDRLKSSETTRRFDPSKAFKHELKENQKPSSALTQGNRYPH
Protein: Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Transport and Golgi organization protein 7) (Tango-7) (Q7JVI3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:16452979}. Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:16452979}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit G-1
- Eukaryotic translation initiation factor 3 subunit F-1
Sequence:
MTSHPVFIDLSLDEQVQELRKYFKKLGAEISSEKSNKGVEDDLHKIIGVCDVCFKDGEPSQIDGILNSIVSIMITIPLDRGENIVLAYCEKMTKAPNLPLGKVCLQSLWRLFNNLDTASPLRYHVYYHLVQVAKQCEQVLEVFSGVDQLKSQFANCPPSSEQMQKLYRLLHDVTKDTNLELSSKVMIELLGTYTADNACVAREDAMKCIVTALADPNTFLLDPLLSLKPVRFLEGDLIHDLLSIFVSEKLPAYVQFYEDHREFVNSQGLNHEQNMKKMRLLTFMQLAESSPEMTFETLTKELQINEDEVEPFVIEVLKTKLVRARLDQANQKVHISSTMHRTFGAPQWEQLRDLLQAWKENLSTVREGLTSVSSAQLDLARSQKLIH
Protein: Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1) (Q6PKC3)
Organism: Homo sapiens (Human)
Function: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- ER degradation-enhancing alpha-mannosidase-like protein 2
Sequence:
MSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKALESTSSPRALVSFTGEWHLETKIYVLDYLGTVRFGVITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVLNYTAENICKWALENQETLFRWLRPHGGKSLLLNNELKKGPALFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHLRRVDAPVLESLALEVPAQLPDPPTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTSGGMKPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVASDSIECSNFLTSYSPFSYYTACCRTISRGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDAPSSVPHIEENRYLFPEVDMTSTNFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAAIVDVKEESHYILDPKQALMKLTLESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSPQNVANSPTKECLQSEAVLQRGHISHLEREIQKLRAEISSLQRAQVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAHSEQLQALYEQKTRELQELARKLQELADASENLLTENTWLKILVATMERKLEGRDGAESLAAQREVHPKQPEPSATPQLPGSSPPPANVSATLVSERNKENRTD
Protein: Cystathionine beta-synthase (EC 4.2.1.22) (Q4QEG9)
Organism: Leishmania major
Interaction partners:
- cysteine-S-conjugate beta-lyase
- Cysteine desulfhydrase
- Putative homocysteine S-methyltransferase
- Adenosylhomocysteinase
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- Putative serine-threonine dehydratase
- Methionine synthase
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- serine O-acetyltransferase
Sequence:
MASANPRNQILANALEAVGNTPCIRLNRVPQKHGIRCEVVAKCEFFNPGGSVKDRIGKQMVLDAEKNGTLKPGSVIVEATSGNTGIGLSMAAAIRGYHMVITMPKKMSHEKETTLQSLGAEVIRTETSLPYDHPDSLIGVARRLRDEKGYVLLDQYTNPSNPGAHYEFTGQEIYDQCGSKVDMVVICAGTGGTITGVAKKLKELIPGVIVVGVDPVGSIIADPEHPGEPVMYHVEGIGYDFVPDVCERKYVDRWVKTRDQESFDLALELHREEGLLVGGSSGSAMAGVLEAAKDLRPDQRCVVLMADGIRNYMGKFADVNWMIEHGFRQGEVTRPTYDTLKKELEEVKAKLAKYESGTQ
Protein: Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Mannosidase alpha class 2B member 2) (O54782)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the early step of spermatogenesis.
Subcellular location: Secreted.
Interaction partners:
- Alpha-mannosidase 2C1
- Lysosomal alpha-mannosidase
Sequence:
MGPLRWLPLLGQLLLLWPRAAQPAGPIRAFVVPHSHMDVGWVFTVQESMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFGISVQYATLNDYFQALHATNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKLMVSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVGYSASVYNPLAWKITTIITLTVAFPNVSVTDELGHPVSTQIQNSTKDPSAYDLLILTTIPGLNYRHYQVMHARGDQAGTRELVAPRANTLKFSLKLRNQPSQEGKRLVPVMNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLEYQANWDVKQGPISDNYLFAPNNTAEPSWEAVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPLDLNREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKAFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYNLTLNDTSIVHPVLWLMLGPKSTMTALHPRSGVALQHGPVVLLKELADEETPVHGPHNPWPVTLPPNLHLQILSVPGWTYSRSHAQHLRNLQRGHPEKPQANLQRVLLRLRHLYEAGEDPVLSRPATVDLKVVLRGLGSVVAVEERSLTGTWDVQMLQRWHWSTKTDHLKGHPTSPPRPPGGSIITVYPKEIRTFFIKFQQ
Protein: Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1) (Q17850)
Organism: Caenorhabditis elegans
Function: Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation. May phosphorylate mlc-4.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8824291, ECO:0000269|PubMed:9535804}; Peripheral membrane protein {ECO:0000269|PubMed:8824291, ECO:0000269|PubMed:9535804}. Cytoplasm {ECO:0000269|PubMed:19023419}. Cell projection, axon {ECO:0000269|PubMed:9535804}. Perikaryon {ECO:0000269|PubMed:9535804}. Note=Co-localizes with ced-10/rac-1 and cdc-42 at hypodermal cell boundaries during embryo elongation (PubMed:8824291). Preferentially enriched at pharyngeal muscle cells boundaries (PubMed:9535804). In CAN neurons, detected in the cell bodies and along the axons (PubMed:9535804). Remains diffused in the cytoplasm during distal tip cell (DTC) migration (PubMed:19023419). {ECO:0000269|PubMed:19023419, ECO:0000269|PubMed:8824291, ECO:0000269|PubMed:9535804}.
Interaction partners:
- Cell division control protein 42 homolog
- SH3 domain-containing protein
- NCK adaptor protein family
- Ras-related protein rac-2
- Ras-related protein ced-10
- Rac-like GTPase
- Arf-GAP domain-containing protein
- Cdc-42 Related Protein
- cGMP-dependent protein kinase interacting domain-containing protein
- Serine/threonine-protein kinase pak-2
Sequence:
MKAFSSYDEKPPAPPIRFSSSATRENQVVGLKPLPKEPEATKKKKTMPNPFMKKNKDKKEASEKPVISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYTQGESSGQKWLQYDMMFIDDAPSRTPSYGLKPQPYSTSSLPYHGNKIQDPRKMNPMTTSTSSAGYNSKQGVPPTTFSVNENRSSMPPSYAPPPVPHGETPADIVPPAIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKPLASLYYLIVAAKKSIAEASNS
Protein: Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (Terra) (Q8BG36)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070, ECO:0000269|PubMed:17605809}.
Interaction partners:
- Telomeric repeat-binding factor 1
- Telomerase reverse transcriptase
- Heterogeneous nuclear ribonucleoprotein A1
- TERF1-interacting nuclear factor 2
- Protection of telomeres protein 1
Sequence:
MTEGQAVPGVGDWEIDVESLDLEEDSCGTPLRATPPQEPSPAAADGEEDEDEEEEDEDVEDEGDGEEPGVSSEVPGRPEQPGGLAPRPPPAAQALPAAAAAPERGATAGGGAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFDRKAVYQRQVRAPSLLAKSILEGYRPMTAETYLGGTLPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLETSQAAALFLPNRMVPGPEYSSYKGTYSPTAGELPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVATTYRQYPLSSRFLVWPKCGPISDTLLYQQYLLNATTSVQALKPGTGWDLKGTRVQDGLSAEQDMMPPKLEGSLVLPHLPEVPASRTDLQVHQVVPERSAFSPPGRNFSPIVDMDCLAAQGHVLTKLSKENTRPSLPLKTNPFHSVFQQTLSDKSGPELNAPFVKEAFEETPKKHRECLVKESQKYTFTIDRCAKDLFVAKQVGTKLSANEPLSFSVESILKRPSSAVTHVSQ
Protein: C-C motif chemokine 3 (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (Small-inducible cytokine A3) (P50229)
Organism: Rattus norvegicus (Rat)
Function: Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.
Subcellular location: Secreted.
Interaction partners:
- Macrophage inflammatory protein-1 alpha receptor
- C-C chemokine receptor type 5
- C-C chemokine receptor type 3
- C-X-C chemokine receptor type 3
- C-C motif chemokine 4
- C-C motif chemokine 5
- C-X-C chemokine receptor type 4
- Chemokine
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine 10
Sequence:
MKVSTAALAVLLCTMALWNEVFSAPYGADTPTACCFSYGRQIPRKFIADYFETSSLCSQPGVIFLTKRNRQICADPKETWVQEYITELELNA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VEV1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFTKWFKKKGGDGGSISEIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMNSQITRDEQDKNPDAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRNV
Protein: Regulatory protein CAT8 (P39113)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activator of the gluconeogenic enzymes FBP1 and PCK1 genes.
Subcellular location: Nucleus.
Interaction partners:
- Regulatory protein ADR1
- Regulatory protein MIG1
- Carbon catabolite-derepressing protein kinase
- 5'-AMP-activated protein kinase subunit gamma
- SNF1 protein kinase subunit beta-2
- SNF1 protein kinase subunit beta-1
- SNF1 protein kinase subunit beta-3
- Protein SIP4
- Phosphoenolpyruvate carboxykinase
- Regulator of drug sensitivity 2
Sequence:
MANNNSDRQGLEPRVIRTLGSQALSGPSISNRTSSSEANPHFSKNVKEAMIKTASPTPLSTPIYRIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRKAYPKGYTESLEERVRELEAENKRLLALCDIKEQQISLVSQSRPQTSTDNTINGNFKHDLKDAPLNLSSTNIYLLNQTVNKQLQNGKMDGDNSGSAMSPLGAPPPPPHKDHLCDGVSCTNHLHVKPTSTSLNDPTAISFEQDEAPGLPAVKALKSMTTHQRSTQLATLVSLSIPRSTEEILFIPQLLTRIRQIFGFNSKQCLYTVSLLSSLKNRLPAPRLLAPSTSTKLKEKDEDKKLDDDSAFVKRFQSTNLSEFVDLKKFLISLKFNINSFSKQSEKPANDQDDELLSLTEIKELLHLFFKFWSNQVPILNNDHFLIYFNNFVEVVKHLSTENLETNNTTKSTVTTNHEIFALKLLMMLQMGLLVKIKMEKIKYTVPKNPKAKYARLMAYYHQLSLIIPKNPYFLNMSTTSLPSLQLLSLASFYYLNVGDISAIYGVRGRIVSMAQQLRLHRCPSAVLSVHSNPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFDIECALPISDVEYKDQLSMENEKADKKAKKIQLQGQVSSFSLQIIRFAKILGNILDSIFKRGMMDERITSEVALVHENALDNWRNQLPEMYYFQITVNGTVNLDEIRATNQRNTETKFDKKDIILFEKKILLLFYFLAKSMIHLPVIATKPLPKNVDNATKKKQSMFNNDSKGATNQDHMILDVDMTSPAIRTSSSYIILQQATNATLTIFQAINSMYLPLPLNVSRTLIRFSLLCARGSLEYTKGGALFLDNKNLLLDTIKDIENDRLLDLPGIASWHTLKLFDMSINLLLKAPNVKVERLDKFLEKKLNYYNRLMGLPPATTTSLKPLFGSQSKNSLENRQRTPNVKRENPEHEYLYGNDSNNNNNSEAGHSPMTNTTNGNKRLKYEKDAKRNAKDGGISKGENAHNFQNDTKKNMSTSNLFPFSFSNTDLTALFTHPEGPNCTNTNNGNVDVCNRASTDATDANIENLSFLNMAPFLQTGNSNIGQNTIENKPMHMDAIFSLPSNLDLMKDNMDSKPEQLEPVIKQNPENSKNNQFHQKGKSTNMEKNNLSFNNKSNYSLTKLMRLLNNDNSFSNISINNFLYQNDQNSASADPGTNKKAVTNAGANFKPPSTGSNTSQGSILGSTKHGMDNCDFNDLGNFNNFMTNVNYSGVDYDYIVDASLGLAPLLVDTPDISNTNTTSTTSNRSKNSIILDTTFNDDLDRSRMNAREVLNPTDSILSQGMVSSVSTRNTSNQRSLSSGNDSKGDSSSQENSKSATGNQLDTPSTLFQMRRTSSGPSASHRGPRRPQKNRYNTDRSKSSGGGSSNTDNVSDLFQWQNAK