wanglab/gogpt-training-data huggingface dataset:
Protein: C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CD antigen CDw198) (P56484)
Organism: Mus musculus (Mouse)
Function: Receptor for the CCL1/SCY1/TCA-3 chemokine.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- C-C motif chemokine 1
- C-C motif chemokine 22
- C-C motif chemokine
- C-C motif chemokine 4
- C-C motif chemokine 5
- Eotaxin
- C-C motif chemokine 2
- C-C motif chemokine 12
- C-C motif chemokine 3
- C-C motif chemokine 20
Sequence:
MDYTMEPNVTMTDYYPDFFTAPCDAEFLLRGSMLYLAILYCVLFVLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQWVFGTAMCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVYAIKVRTASVGTALSLTVWLAAVTATIPLMVFYQVASEDGMLQCFQFYEEQSLRWKLFTHFEINALGLLLPFAILLFCYVRILQQLRGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHILDGCATRQRLALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKSCSHIFLYLGRQMPVGALERQLSSNQRSSHSSTLDDIL
Protein: Cytochrome b5 (M9NEX3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}. Microsome membrane {ECO:0000256|ARBA:ARBA00037877}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037877}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037877}.
Interaction partners:
Sequence:
MSKEIRLATVNEHNKATDLWVVIDNKVYDVTKFRLEHPGGEESLVDEAGRDATKAFNDVGHSSEAREMLKKYYIGDLAAADIKKKSPISATPTDAAATPKQCCILS
Protein: Small ribosomal subunit protein eS19A (40S ribosomal protein S19a) (P39018)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein eL15
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein uL22
- Ubiquitin-ribosomal protein eS31 fusion protein
- FI01658p
- Large ribosomal subunit protein eL38
Sequence:
MPGVTVKDIDQHAVTKAVAVFLKKTGKLKVPDQMDIVKTAKFKELAPYDPDWFYVRCASILRHLYHRSPAGVGSITKIYGGRKRNGVHPSHFCRAADGAARKALQALEHARLVEKHPDGGRKLSSIGQRDLDRIANQIVFKQRDAAKQTGPIVISK
Protein: Ceramide synthase 3 (CerS3) (Dihydroceramide synthase 3) (LAG1 longevity assurance homolog 3) (Sphingosine N-acyltransferase CERS3) (EC 2.3.1.24) (Ultra-long-chain ceramide synthase CERS3) (EC 2.3.1.298) (Very-long-chain ceramide synthase CERS3) (EC 2.3.1.297) (Q8IU89)
Organism: Homo sapiens (Human)
Function: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1A3B0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- 3-ketodihydrosphingosine reductase
- Alkaline ceramidase 1
- Sphingolipid delta
- Ceramide glucosyltransferase
- Sphingolipid delta
- Acid ceramidase
- Sphingomyelin phosphodiesterase
- Alkaline ceramidase 2
- Ceramide kinase
Sequence:
MFWTFKEWFWLERFWLPPTIKWSDLEDHDGLVFVKPSHLYVTIPYAFLLLIIRRVFEKFVASPLAKSFGIKETVRKVTPNTVLENFFKHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMKSIQDVRSDDEDYEEEEEEEEEEATKGKEMDCLKNGLRAERHLIPNGQHGH
Protein: ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Q8R0H9)
Organism: Mus musculus (Mouse)
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface (By similarity). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9UJY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJY5}. Endosome membrane {ECO:0000250|UniProtKB:Q9UJY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJY5}. Early endosome membrane {ECO:0000250|UniProtKB:Q9UJY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJY5}.
Interaction partners:
- Rab GTPase-binding effector protein 1
- Cation-independent mannose-6-phosphate receptor
- ADP-ribosylation factor-binding protein GGA3
- ADP-ribosylation factor-binding protein GGA2
- Sortilin-related receptor
- ADP-ribosylation factor 1
- Beta-secretase 1
- Cation-dependent mannose-6-phosphate receptor
- Sortilin
- ADP-ribosylation factor 3
Sequence:
MEPAMEPETLEARINRATNPLNKELNWASINSFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKSKILELLYSWTVCLPEEVKIAEAYQMLKKQGIVKSDPKLPEDAIFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGAASSSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATASSIPGSTSALLDLSGLDLPPPGTTQPATPTRPGNQSSPEQLSASVSLLDDELMSLGLSDPTPPSGTSSDSVGWDNFQSSDGTESSVPPPAQAPSMDCRPPAQAPPPTSSGLDDLDLLGKTLMQQALPPEAQQVRWEKQQPAPRLTLRDLQSKSSSPSPGAASLLHTTSPEPPGPPPQATPTEFSLTSITVPLESIKPSSILPVTVYDQHGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVRLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTMGDQTYNEMGDVDQFPPPETWGSL
Protein: Evasin P1170 (A0A0K8RD51)
Organism: Ixodes ricinus (Common tick) (Acarus ricinus)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MELKTFAFLQIAAFIALGVQIFFVGTDALGDEDQLFSVEYCGTNCTQQDDGKWTPCSGKNGKCKCYHEDGKRYGLCLYTEYTDFSQYPNPEGSEIENTRPRP
Protein: Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) (Q90WY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Cholinergic receptor nicotinic beta 3 subunit b
Sequence:
MDSPCPVAVGLPGHTNGTGGTSSPTCNQSMIKLAPYSPEATAAFATAITLMMLITIVGNILVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRSVWCEIYLALDVLFCTSSIVHLCAISLDRYMSISRAVTYGPKRTPKRIKCAILVVWLISAVISFPPLLSMNKNKGGGESGALPQCQLNDERWYILYSTIGSFFAPCLIMILVYMRIYQIAKQRTRCPPGEPRKEAPANATTPQHKIQNGRGDETPGTLQKKARPPTLAVSQVESVQQAANTPIANNLLQAPSTTLTPTTPCPSPSPSNSSEVAPSKSKEGKKEKKKKKNNKNKNKKEPDNNNGESMSSDSDTEQGGRGLEVPCTPTMTPSGIHSPATMQKYRDMIATAKGAKLVARKAKQDGTPNSARRKAMVNREKRFTFVLAVVIGVFVICWFPFFFSYSLQAVCPESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAFKKILCKNTKGTFF
Protein: pre-mRNA splicing regulator USH1G (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein) (Q495M9)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs. May also participate in recycling of snRNPs back to Cajal bodies during splicing. Plays a role in regulating MAGI2-mediated endocytosis. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing.
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250|UniProtKB:Q80T11}; Peripheral membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80T11}. Nucleus speckle {ECO:0000269|PubMed:34023904}. Nucleus, Cajal body {ECO:0000269|PubMed:34023904}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q80T11}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q80T11}. Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (By similarity). In photoreceptor cilia, detected predominantly at the cilium base (By similarity). Expressed in the pericentriolar region of the centrosome (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q80T11}.
Interaction partners:
- Harmonin
- Unconventional myosin-VIIa
- Whirlin
- Cadherin-23
- Protocadherin-15
- PDZ domain-containing protein 7
- Adhesion G-protein coupled receptor V1
- Usherin
- Unconventional myosin-XV
- Clarin-1
Sequence:
MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSSLTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKSARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (O77387)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MSFIDEYDLDMYKNIVMANNCKDEELLCIFNTSSFLNTICFFIFVIMFLWALAILSRFYLSYNIMKYLKNRKAIYMKNMSRYIDDIKMLCRSHVNDIIRIKKKITPRHVEKINLNISINNNIQLFKNYLSSSSNDLNNLYKYSISFTFSSKNCIYIRLFFGVLLEEINDMIYNKTESYRNLNYYRDDENNKNMNHHNNLNNNNTVICIDNFKNFFREGFIKTLPSNKKNSSDATTFLLDNDKNDFFITNESYIENIIDFHTCYYKTSQSFYTSGTDLTYTMPYDENFCVTDILNRIEIEKKQKDENNSNNYSNNSSNNNSPNNDDNIYNNNNNNNNNNNDYNNNIYNHIYSDNLMFNDNISRAYRNNHLDSTNNNIFLSSEHTNRYKNNKVFLQNDSKILNHTSVDENIRIPLIIVLNDVPPTDEYYGHKENIKNNYNNINTTTTTNTTTTNNTTTTSHNNNNNNCNTLIVLVGFKKIKDKYKPFIIKDISVLSYSLSEQYDNLRKKKKKKGKSISNNNNYNNQIYQFVDILDIYGHEEHDKECLICMTSYKDTLLMPCRHSSFCYDCMKSLRQEKCPICRCLFTSFIKFPLKNVERVDT
Protein: Anaphase-promoting complex subunit 11 (Q38DY9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cdc23 domain-containing protein
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 16, putative
- Cyclosome subunit 1, putative
- Ubiquitin-conjugating enzyme E2, putative
- E2 ubiquitin-conjugating enzyme
- Uncharacterized protein
- Anaphase-promoting complex subunit 10
- Non-specific serine/threonine protein kinase
- Uncharacterized protein
Sequence:
MDIKVKSAHFVARWVWDCRDDTCGICRQQFEACCPQCRFPGEDCPIVTGKCTHTFHIHCIERWAEREQDNTECPMCRQTWEF
Protein: GH07831p (Q95SQ7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MAHTRRPSDGLLARVNFPLYAVDMLTSRHILVAGGGGSSKTGVANGFEIYELYHNGSHFCAEEVLRHDTGANVVMNFAVRNGGRRGYLCAGQEAHCQMYYVQPRVQSEEDGNGNGVGVGDGKPAPEERPHENGNVRQRNAHSGVEPVANGHRPPLSTADILRQFRRLHFDIQAADVIQTDFLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWKTPEGAKYLFKRCRYGTVEAQKDNYRLFTIANPLGKVGKQRGFLQHWDCASGQLRQAVAIDESLSSLAVRDDGRFVAVGTMFSGSVSMYIAFSLQRVLHIPHAHSMFVTGLQFLPITNEEGPPISSDTEAAVLSISVDNKVCIHSLSQRRTIPAWIAIVFLIVMIFAVFVLCSYIGI
Protein: Protease, serine, 1 (Trypsin 1) (Serine protease 1 (trypsin 1)) (Trypsinogen 16) (Q9Z1R9)
Organism: Mus musculus (Mouse)
Interaction partners:
- Serine protease inhibitor Kazal-type 1
- Proteinase-activated receptor 2
- Chymotrypsinogen B
- Amyloid-beta precursor protein
- Proteinase-activated receptor 1
Sequence:
MSALLFLALVGAAVAFPVDDDDKIVGGYTCRENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNINVLEGNEQFIDAAKIIKHPNFNRKTLNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQCLDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALPDNPGVYTKVCNYVDWIQDTIAAN
Protein: Probable RNA polymerase II nuclear localization protein SLC7A6OS (Solute carrier family 7 member 6 opposite strand transcript homolog) (Q5U3I2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Directs RNA polymerase II nuclear import.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB3
- Solute carrier family 35 member F2.
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase II subunit RPB11-a
- Polymerase
- Heme transporter hrg1-A
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Solute carrier family 26 member 11.
- Mitochondrial outer membrane protein SLC25A46
Sequence:
MDPSTTILRVKRKRGTDPADALLLACKRIRPEATAAQPSDESEPEPQEPKIENSVFKLVATVVSQDAPVQPHVREALARPRLAHHALRPSQGSSQRIIGDLRSVKWSTRREERYRILSSHRAGLPSEPAPAGGGGEENHDSHAESRDGLPLGEVQVFDILHEEEDVKVPGKMVVSDPETILCNSVKMIREKLSVSGAGLGTEHREKEDDYVYDLYYQETATPGWIQDILSVRPYSQEGELVPDEVAWEEEVYEDEDDENAEANWRNDYPEESSEGDSEGEERYGGCWSEEHSYSRRSRECYRRDMIDELENDKDEDDEEREYNDSD
Protein: Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) (P61970)
Organism: Homo sapiens (Human)
Function: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}. Nucleus outer membrane {ECO:0000250|UniProtKB:P61972}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P61972}. Nucleus inner membrane {ECO:0000250|UniProtKB:P61972}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10679025}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000269|PubMed:10679025}.
Interaction partners:
- GTP-binding nuclear protein Ran
- Nuclear pore glycoprotein p62
- NTF2-related export protein 1
- Nuclear RNA export factor 1
- Nucleoporin p54
- Nuclear pore complex protein Nup153
- NTF2-related export protein 2
- Ran GTPase-activating protein 1
- Ran-specific GTPase-activating protein
- Nuclear RNA export factor 3
Sequence:
MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG
Protein: Age3p (A0A1D8PCP6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- ADP-ribosylation factor
- ADP-ribosylation factor GTPase-activating protein
- ADP-ribosylation factor
- Arf family guanine nucleotide exchange factor
- Probable electron transfer flavoprotein subunit beta
- Coatomer subunit beta'
- Arf3p
- Rab family GTPase
- Coatomer subunit epsilon
- Protein transport protein SEC22
Sequence:
MSIDPETRRKLLNLQKTGENKKCFDCSAPNPQWASPKFGIFICLECAGVHRGLGVHISFVRSITMDQFKPEETLRMEIGGNERLKKYFIDNGVDLNLSPKQKYDNYVAEDYKEMLTCEVEGKEFVAKDHSGEKLPDINNTASTTTDPVSRGRPTPVPLTNEQKQKNEAYFADLGAKNDQRPDHLPPSQGGKYGGFGNTPAPSNTTSNNNNNNNSNNNNNNNNNNSSLSSFTLDNFQNDPLGTFTKGWGLFSSTVVKSVQEVNNSVIKPSIDQIQSSKITGQAKTAMAQFGQKMQQTGKYGQETFQTFTKDINENGLNKTLDSTFGGIFGHNNNNNGSNQGNQVPNAFGFKKPDNGVKYESLSGGSKKNDDDDDDKWDDF
Protein: Protein lin-7 homolog (Q9U245)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
Interaction partners:
Sequence:
MDNPDGPNLERDVQRILELMEHVQKTGEVNNAKLASLQQVLQSEFFGAVREVYETVYESIDADTTPEIKAAATAKATVAAFAAAEGHAHPRIVELPKTDQGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLIAVNGNVEAECHEKAVDLLKSAVGSVKLVIRYMPKLLDEMERRFERQRIRSTQQSPTLPTPSSSTNPRR
Protein: Lysine demethylase 2B (A0A0C4DGG3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
Protein: Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I) (Q61288)
Organism: Mus musculus (Mouse)
Function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P37023}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Bone morphogenetic protein 10
- Growth/differentiation factor 2
- Bone morphogenetic protein receptor type-2
- Transforming growth factor beta-3 proprotein
- Endoglin
- TGF-beta receptor type-2
- Activin receptor type-1
- Transforming growth factor beta-1 proprotein
- Activin receptor type-2A
- Bone morphogenetic protein 4
Sequence:
MTLGSFRRGLLMLSVAFGLTRGDLAKPSKLVNCTCESPHCKRPFCQGSWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVIH
Protein: AT3g07470/F21O3_18 (Q94AG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g46230
- Uncharacterized protein T1P2.11
- T19F6.7 protein
- Similarity to unknown protein
- T31J12.3 protein
- peptidylprolyl isomerase
- At1g56580/F25P12_18
- Adenylate kinase 4
- At1g50450/F11F12_20
Sequence:
MMLRIVQIAFLCLVLVAGISISTAISETETIYEILLANGLPSGIFPKGVREFTFDVETGRFSVYLNQACEAKYETEIHYDANITGTIGSAQISDLSGISAQELFLWFPVKGIRVDVPSSGLIYFDVGVVRKQYSLSLFETPRDCVPVRGIHKVELPLYRVDQNLGRNII
Protein: Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] (Q2KJ63)
Organism: Bos taurus (Bovine)
Function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Kininogen-1
- Coagulation factor XII
- Plasminogen
- Factor XIIa inhibitor
- Pancreatic trypsin inhibitor
- Lysosomal Pro-X carboxypeptidase
- Coagulation factor XI
- Tissue factor pathway inhibitor
Sequence:
MIALRQAAYFICLFATVSCGCLTQLYHNIFFRGGDVSAMYTPDAQYCQLMCTFHPRCLLFSFLPENSTSDADKRFGCFLKDSVTGTLPRVSRTGAISGHSLKRCGHQISACHRSIYKGIDMRGVNFNASKVRSAKECQERCTNNIHCQFFTYATKTFFSAEYRNTCLLKRSPQGTPTRIKVLSDVESGFSLKACGNSKIGCRVDIFQHSAFSDVDVAGIIAPDAFVCRTICTYHPSCLFFTFYTNAWKTDSQRNVCFLKTSQSGSPSSPTPQENAISGYSLLTCKQTLPGTEPCHSKIYPQVAFEGEELHVTFVKGVDGCQETCTKMIRCQFFTYSLFPEDCRGEKCKCSLRLSLDGSPTNITYGTQASSGYSLRLCKRGDSRVCTTKRTRIVGGTNASWGEWPWQVSLQVKQRAQSHLCGGSIIGRQWVLTAAHCFDGLLLSNIWRIYGGILNLSEITTETSFSQIKEIIVHPNYKISEGSHDIALIKLEAPLNFTDLQKAICLPSKDDTKPVYTDCWITGWGFTEEKGKIQNTLQKANIPLISNEECQKSYRDYKITKQMICAGYKEGGKDACKGDSGGPLVCQHEETWHLVGITSWGEGCARREQPGVYTKVAEYVDWILEKTQDSHGQPLRK
Protein: Alternative protein TRIM65 (L8E9Q5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCPELPGRAPLLGGARVRPLGDTGRLLPATATVQAGAPHRQHWPGTLLLGALRPGGQPPGLAQRGSPAPPRGVRAAPGHGFGPGLRLPHLLQPGAPDPAPVHLPCPLQPAPHPRLLAPRG
Protein: UDP-glucuronosyltransferase 1A6 (UGT1A6) (EC 2.4.1.17) (Phenol UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-6) (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (UGP1A1) (UGT1A7) (Q64435)
Organism: Mus musculus (Mouse)
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.
Subcellular location: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome P450 1A1
- Cytochrome P450 1B1
- Cytochrome P450 2E1
- Beta-glucuronidase
- UDP-glucose 6-dehydrogenase
- Sulfotransferase 1E1
- Carbonyl reductase 1])
- Aromatase
- 11-beta-hydroxysteroid dehydrogenase 1
- 17-beta-hydroxysteroid dehydrogenase type 3
Sequence:
MACLLPAAQTLPAGFLFLVLWASVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIMVLVPEVNLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKDSATLSFLRENKFDALFTDPAMPCGVILAEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYLYYCLYSKYEIIASDLLKRDVSLPSLHQNSLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH
Protein: Set1 complex component swd1 (Set1C component swd1) (COMPASS component swd1) (Complex proteins associated with set1 protein swd1) (O42858)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The Set1 complex specifically methylates 'Lys-4' of histone H3.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Set1 complex component swd2
- Set1 complex component swd3
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Set1 complex component sdc1
- Set1 complex component ash2
- Set1 complex component spp1
- Set1 complex component shg1
- Polyubiquitin
- Polyadenylation factor subunit 2
- Histone H4
Sequence:
MNLELLDPFSIPDYPEALTTTLKHGHATSIRFSTNGYHLASGLVNGSVVIWDLSTFSVSRVLTGHTRAIQSVCWSSCDRFLLTASRDWKCILWDLRDGSIVYQVVLSAPVWSASLHPHKINTFVASLLDESPQLIIVDDGIPKHKYLPTNPDIDENYSDRRNRSKHVTLVSFFHPSGEYILSGTSKGWFHVIDASTTKIRSSHRITSQSIKQIRLSFCKRFLIFNSTDRVIRTVSIQDLDNPEVEHKFQDVVNRLQWNSCGFSQTGEFVFATTYQMAHAIYVWERGMGSLVKILEGPKEELVDVDWHPVFPCVASVGLDSGSIYIWAVEQKESWSAFAPDFQELEENIEYEEPEDEFDIHDETGKSEEEEYFTSVVKILPHDSSAEQPFVMPPTLSSS