wanglab/gogpt-training-data huggingface dataset:
Protein: Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55) (Q86WV1)
Organism: Homo sapiens (Human)
Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Cell membrane {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000269|PubMed:9671755}.
Interaction partners:
- FYN-binding protein 1
- Lymphocyte cytosolic protein 2
- Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
- Tyrosine-protein kinase Fyn
- Tyrosine-protein kinase Lck
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Growth factor receptor-bound protein 2
- Tyrosine-protein kinase ZAP-70
- Ras association domain-containing protein 5
Sequence:
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPKEYLTTAFEVEER
Protein: Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box RNA helicase DEAD1) (mDEAD1) (DEAD box protein 5) (RNA helicase p68) (Q61656)
Organism: Mus musculus (Mouse)
Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P17844}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P17844}. Cytoplasm {ECO:0000250|UniProtKB:P17844}. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm. {ECO:0000250|UniProtKB:P17844}.
Interaction partners:
- Ribonuclease 3
- ATP-dependent RNA helicase A
- Cellular tumor antigen p53
- Probable ATP-dependent RNA helicase DDX17
- Microprocessor complex subunit DGCR8
- RNA-binding protein 39
- Serine/arginine repetitive matrix protein 2
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoprotein H
- Exosome RNA helicase MTR4
Sequence:
MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSNLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVANMHNGMNQQAYAYPLPQAAPMIGYPMPTGYSQ
Protein: Protein LPA3 (Protein LOW PSII ACCUMULATION 3, chloroplastic) (Q8H0W0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305|PubMed:22223895}.
Interaction partners:
- Protein LPA2
- Inner membrane protein ALBINO3
- Protein LOW PSII ACCUMULATION 1
- Thylakoid membrane protein TERC, chloroplastic
- Photosystem II 5 kDa protein, chloroplastic
- Chloroplast protein HCF243
- Photosystem II CP43 reaction center protein
- Protein PAM68, chloroplastic
- Inositol-pentakisphosphate 2-kinase
Sequence:
MAMAIAMLPALFSSPSILTSRIRCGATANSGGAISSTSSNSDPRRGVPLYKPKSYEVLATDAANSLAFALQDSKSRLEIDFPPLPSSISSYKGSSDDFIDANIQLAVTVVRKLQEKIETRACIVFPDKPEKRRASQRFKAAFDSVDGISIGSLDDIPGTSVTNFFRSIRSTLDFDFEDENEGTWEPKEPPTLYIFINCSTRELSFIEKFVETFASSTPALLFNLELDTLRADLGLLGFPPKDLHYRFLSQFIPVFYIRTREYSKTVAVAPFVLNYNGALFRQYPGPWQVMLKQTDGSFACVAESPTRFTLGETKEELLQVLGLQEEKGSSLEFLRRGYKSATWWEEDVELEASSNWRN
Protein: At2g07725 (Ribosomal L5P family protein) (Rpl5) (Q6NMS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Eukaryotic translation initiation factor 4B3
- Probable mediator of RNA polymerase II transcription subunit 19b
- Large ribosomal subunit protein P3y
- Large ribosomal subunit protein P3z
- Eukaryotic translation initiation factor 4B2
- Eukaryotic translation initiation factor 4B1
- Protein LATERAL ROOT PRIMORDIUM 1
- Zinc finger, C3HC4 type
- G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2
Sequence:
MFPLNFHYEDVSRQDPLLKPNHANVMEVPGSCEIRVVPKAPYNFIIKNGKLAMEIPRGQKFIQTQRGSTGKSFRSNPFLGSNKDKGYVSDLARQSTLRGHGMSNFSVRISTVMSLLDFPVEIRKNSIQFSMETEFCEFSPELEDHFEIFEHIRGFNVTIITSANTQDETLPLWSGFLQKDEGETQ
Protein: Odorant receptor 85b (Q9VHQ7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to 2-heptanone, amyl acetate, and butyl acetate.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 85a
- Odorant receptor 22a
- Odorant receptor 59b
- Odorant receptor 7a
- Odorant receptor 42b
- Odorant receptor 33a
- Odorant receptor 98a
- Odorant receptor 67d
- Odorant receptor 47a
- Odorant receptor 65a
Sequence:
MEKLMKYASFFYTAVGIRPYTNGEESKMNKLIFHIVFWSNVINLSFVGLFESIYVYSAFMDNKFLEAVTALSYIGFVTVGMSKMFFIRWKKTAITELINELKEIYPNGLIREERYNLPMYLGTCSRISLIYSLLYSVLIWTFNLFCVMEYWVYDKWLNIRVVGKQLPYLMYIPWKWQDNWSYYPLLFSQNFAGYTSAAGQISTDVLLCAVATQLVMHFDFLSNSMERHELSGDWKKDSRFLVDIVRYHERILRLSDAVNDIFGIPLLLNFMVSSFVICFVGFQMTVGVPPDIVVKLFLFLVSSMSQVYLICHYGQLVADASYGFSVATYNQKWYKADVRYKRALVIIIARSQKVTFLKATIFLDITRSTMTDLLQISYKFFALLRTMYTQ
Protein: 60S ribosomal protein L26, putative (Q38D25)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Ribosomal protein
- 60S ribosomal protein L19, putative
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L39, putative
- 60S ribosomal protein L29
- 60S ribosomal protein L27, putative
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L28, putative
Sequence:
MVGIKCRNRRKARRAHFQAPSHVRRILMSAPLSKELRAKYNVRSMPVRKDDEVRVKRGKFKGREGRVTACYRLKWVIHIDKVSCEKANGTTVPVGVHTSNVEITKLKLNTRRKAILERKDRSTKTDKSKGKVTAAEKAMQQMD
Protein: T3SS effector protein NleH (T3SS secreted effector NleH (EC 2.7.-.-)) (Type III secretion system effector kinase NleH1-2) (A0A0F3UH49)
Organism: Escherichia coli
Interaction partners:
Sequence:
MLSPSSINLGCSWNSLTRNLTSPDNRVLSSVRDAAVHSDSGTQVTVGNRTYRVVVTDNKFCVTRESHSGCFTNLLHRLGWPKGEISRKIEAMLNTSPVSTTIERGSVHSNRPDLPPVDYAQPELPPADYTQSELPRVSNNKSPVPGNVIGKGGNAVVYEDMEDTTKVLKMFTISQSHEEVTSEVRCFNQYYGSGSAEKIYNDNGNVIGIRMNKINGESLLDIPSLPAQAEQAIYDMFDRLEKKGILFVDTTETNVLYDRMRNEFNPIDISSYNVSDISWSEHQVMQSYHGGKLDLISVVLSKI
Protein: ATP synthase subunit a (F-ATPase protein 6) (P00854)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit 4
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit J, mitochondrial
- ATP synthase subunit d
- Cytochrome b
- ATP synthase subunit epsilon, mitochondrial
- ATP synthase subunit H
Sequence:
MFNLLNTYITSPLDQFEIRTLFGLQSSFIDLSCLNLTTFSLYTIIVLLVITSLYTLTNNNNKIIGSRWLISQEAIYDTIMNMTKGQIGGKNWGLYFPMIFTLFMFIFIANLISMIPYSFALSAHLVFIISLSIVIWLGNTILGLYKHGWVFFSLFVPAGTPLPLVPLLVIIETLSYFARAISLGLRLGSNILAGHLLMVILAGLTFNFMLINLFTLVFGFVPLAMILAIMMLEFAIGIIQGYVWAILTASYLKDAVYLH
Protein: At2g31800 (Integrin-linked protein kinase family) (Q1JPN7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANVVGQLKRGISRQFSTGSLRRTLSRQFTRQASHDPRRNNMRFSFGRQSSLDPIRRSPDGSNGPQLAVPDNLDATMQLLFVACRGDVEGVQDLLDEGIDVNSIDLDGRTALHIAACEGHVDVVKLLLTRKANIDARDRWGSTAAADAKYYGNMDVFNILKARGAKVPKTKRTPMVVANPREVPEYELNPQELQVRKADGISKGIYQVAKWNGTKVSVKILDKDLYKDSDTINAFKHELTLFEKVRHPNVVQFVGAVTQNVPMMIVSEYHPKGDLGSYLQKKGRLSPAKVLRFALDIARGMNYLHECKPEPVIHCDLKPKNIMLDSGGHLKVAGFGLISFAKLSSDKSKILNHGAHIDPSNYCMAPEVYKDEIFDRSVDSYSFGVVLYEMIEGVQPFHPKPPEEAVKLMCLEGRRPSFKAKSKSCPQEMRELIEECWDTETFVRPTFSEIIVRLDKIFVHCSKQGWWKDTFKFPWK
Protein: Serine/threonine-protein kinase ppk29 (EC 2.7.11.1) (Q9USS2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor cwf21
- RNA-binding post-transcriptional regulator cip2
Sequence:
MSVASFLTGEKLLAGSKFVIGKYNVTIEKYIAEGGFSHVYLVQTNSKTDGSPITAVLKRMYSPDENALRFVKTEIETMELLKSNPHVVSYIDSCIFPLEKAGVNTGFEILLLMEYCAGGGLIDFMNQRLQTRLSEHEVLKIISDIVQGVASLHYLRPPLIHRDLKVENVLLSFNTFKLCDFGSVTEPMHAAENSSEIQALEKSINTFTTYQYRAPEMINLYSGLGIDEKSDMWALGVLLYKLCYYTTPFETQGPNAILTASYSFPPFPPYSHSLKNVIIALLQPNPCLRPNIFQLMCEICRLRGTALPFRDIYSGRESSFYDLHNRKIMSLLRQTTTTPFAGNQVMPTPQVQGSRPPPPPPMPAPIYNVPNVPTVPTVSPNPFLQPTFSGTSQASAHPSIHSQSATFNNTQDVNRQSVSSPKVVSSSSVTGSGASGRKVYTPQSKNPFPISQGVTGTSSKFSASEVTEDNGSPNAGLDADNVDVEEVVNQRYPDLNELESQLTSHTNITTSSHHNPREQEIAKLADDAFASFRQTAGTSTANSTHTTGTQDISAFDTNFSEGVGSVRSSFDFPDRPVSRRPSSTSRSSVKITGPSSPNARSMAYEQHSFNLDDLSNTNFGSNNSLRHAKSFSKYYSPSHKDSNKTSRNTSKEGLPSSPTMLYRTTSNTRGDYIVQRTQQSANPLTNIEPQDMSNLSTDINASDVVADSTNSILYPTSTASSVANTIASDVDDFGTFNGLQRTVSLHSERASLDKKRPSFHDKNPYFKFSPSKYVDEGLEGESELRERVRSYANRSSSSFHNPDLTDTEIQETSFNNDLRPVASIQSAETSRSVSDRPANFPEELNDTLFEQKYPGIVDYEEPNSNAEKNVNI
Protein: Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (O70368)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
VMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYPDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPPAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHEPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC
Protein: HIRA-interacting protein 3 (Q9BW71)
Organism: Homo sapiens (Human)
Function: May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
Subcellular location: Nucleus {ECO:0000269|PubMed:17391060, ECO:0000269|PubMed:38334665}. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
Interaction partners:
- Protein HIRA
- Histone H2B type 2-E
- Casein kinase II subunit alpha'
- Kinesin-like protein KIF22
- Seizure 6-like protein 2
- PAXIP1-associated glutamate-rich protein 1
- Double C2-like domain-containing protein alpha
Sequence:
MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPPDWSHMRGIISSDGESN
Protein: Transcriptional activator ARO80 (Q04052)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transaminated amino acid decarboxylase
- Aromatic amino acid aminotransferase 2
- Aromatic/aminoadipate aminotransferase 1
Sequence:
MSAKKRPSGNAAFELPKRRRTYQACISCRSRKVKCDLGPVDNPHDPPCARCKRELKKCIFSSNKGTSNDLPPNSINAISLPSLGKSKQEIQNDSTSPILSDVPLSRKGISSEKSFKSEGMKWKLELSSMQNALEFLAQAAGTVAKEGAKEIIKEKSTTPKPLKSSLDATNKSATDEGLKRLSKSDSTNTLYENTADMLNHTLNTNRKTSQLMEEIGKVRPPPTRKIDDFDYIGPDSLLTKEEAIELIEAFFLTMHPFFPNIPLQLHDPKELAEYPILFCAILTVSARYHPFDTLGLDNGEDGMRHIEVHDKLWVYCQKLISQTIWAEASTRSIGTVLAFIIFTEWNPRSIHYKWSDYANDPELNNVNARGSKNISTRKDEEGLTGVGAIRRSDRMSWMLTGSAVRLAQDMGFIENSSKVFIVTHISETTSAMNMNQRSLLAESFSVLNLNLGKIENDGNESNEDYLGNEKFYLNEILPDEESKLRWKRVFENSENDHDNEKNFLTDWEREFLNDEYVLYYSNKKDDTNLAQNHIPPFPLRFSFAQRAKIEIIRILSIAYETIYCEKNKRKLATTDQRHNLSVLSVFSPLIEGWLSNYRELLVPLSDVPFSLADRKNKKQIFDNIDRINGESIITDFNYCQLYIFSLALQVDGKTSRLNMNEIVTSARYVELAYRSAKEILSSAKRVSRQGMLKYMPVRWVIRIIRSIAFIVKCYLTLTGSELATNPDARNILKLSAISVDETFDIIRDTAVTLKEATPDELHLCQRYAAILMYLCTEMKLRKKSYLERPPLLRDGTTPLESNRESSLEGQDLTKKPIFSKRIGYNKTETTFEPSERPLTEEINSNSQNSNDTSSKGIVDPFVEQNNDITTALLNNELFQGPSLSDEVTDWFGASEDIGLEFVEPWTELIEQRYMQCGDGDNNNFENLYNLFVNSNNINNDINNSRPITRK
Protein: Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog) (Q9H7Z3)
Organism: Homo sapiens (Human)
Function: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm. U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis. Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites. Plays a role in DNA damage response.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:30842217}. Nucleus, nucleoplasm {ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. Nucleus {ECO:0000269|PubMed:29902117}.
Interaction partners:
- Exosome RNA helicase MTR4
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Zinc finger C3H1 domain-containing protein
- Zinc finger CCHC domain-containing protein 8
Sequence:
MALFPAFAGLSEAPDGGSSRKELDWLSNPSFCVGSITSLSQQTEAAPAHVSEGLPLTRSHLKSESSDESDTNKKLKQTSRKKKKEKKKKRKHQHHKKTKRKHGPSSSSRSETDTDSEKDKPSRGVGGSKKESEEPNQGNNAAADTGHRFVWLEDIQAVTGETFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSTEKKHSRKQVERYFTKKSVGLMNIDGVAISSKTEPPSSEPISFIPVKDLEDAAPVTTWLNPLGIYDQSTTHWLQGQGPPEQESKQPDAQPDSESAALKAKVEEFNRRVRENPRDTQLWMAFVAFQDEVMKSPGLYAIEEGEQEKRKRSLKLILEKKLAILERAIESNQSSVDLKLAKLKLCTEFWEPSTLVKEWQKLIFLHPNNTALWQKYLLFCQSQFSTFSISKIHSLYGKCLSTLSAVKDGSILSHPALPGTEEAMFALFLQQCHFLRQAGHSEKAISLFQAMVDFTFFKPDSVKDLPTKGQVEFFEPFWDSGEPRAGEKGARGWKAWMHQQERGGWVVINPDEDDDEPEEDDQEIKDKTLPRWQIWLAAERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSHDLQFQLVEAFLQFLGVPSGFTPPASCLYLAMDENSIFDNGLYDEKPLTFFNPLFSGASCVGRMDRLGYPRWTRGQNREGEEFIRNVFHLVMPLFSGKEKSQLCFSWLQYEIAKVIWCLHTKNKKRLKSQGKNCKKLAKNLLKEPENCNNFCLWKQYAHLEWLLGNTEDARKVFDTALGMAGSRELKDSDLCELSLLYAELEVELSPEVRRAATARAVHILTKLTESSPYGPYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTDSCSRLISLAKCFMLFQYLTIGIDAAVQIYEQVFAKLNSSVFPEGSGEGDSASSQSWTSVLEAITLMHTSLLRFHMKVSVYPLAPLREALSQALKLYPGNQVLWRSYVQIQNKSHSASKTRRFFDTITRSAKPLEPWLFAIEAEKLRKRLVETVQRLDGREIHATIPETGLMHRIQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQNCPWAKVLYLDAVEYFPDEMQEILDLMTEKELRVRLPLEELELLLED
Protein: Protein SNOWY COTYLEDON 3 (QWRF motif-containing protein 1) (Q8GXD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable microtubule-associated peroxisomal protein required for chloroplast biogenesis and for the formation of the prolamellar body and prothylakoids in etioplasts. Not involved in peroxisomal metabolism, including mobilization of storage compounds during germination, fatty acid beta-oxydation or photorespiration.
Subcellular location: Peroxisome {ECO:0000269|PubMed:20978221}. Note=Located at discrete small spots potentially associated with the surface of the peroxisome.
Interaction partners:
- CAAX amino terminal protease family protein
- Protein disulfide-isomerase SCO2
- Serine/threonine-protein kinase STN8, chloroplastic
- AT4g31560
- Hydrolase-like protein family
- Protein SEEDLING PLASTID DEVELOPMENT 1
- Malonyl-CoA decarboxylase family protein
- 2-succinylbenzoate--CoA ligase, chloroplastic/peroxisomal
- Elongation factor G, chloroplastic
Sequence:
MVAAIPQGAAISNTDSKNPPPRDRQDKPQLTANNGGLQRRPRAAKNVPSRYLSPSPSHSTTTTTTTATSTSTSSSSSVILRSSKRYPSPLLSRTTNSASNLVYTPSSLPKRSQSVDRRRPSAVSDTRTEMSAATKMLITSTRSLSVSFQGEAFSFPISKKKETATPVSHRKCTPERRRATPVRDQRENSKPVDQQLWPGASRRGSSESVVPNSLSRSVDSDSDDGRKLGSGFVGRSMLQHSQSSRVSGDGRLNLGFVGGDGMLEMRDENKARQSTHPRLASSVSCDFTASDTDSVSSGSTNGAHECGSGEVSKTRSLPRNGMASTKFWQETNSRLRRMQDPGSPQCSSPSSRISSISSKFSQSKRFSSDSPLTSSPRGMTSPIRGATRPASPSKLWATATSAPARTSSSPSRVRNGVSEQMNAYNRTLPSILCFSADIRRGKIGEDRVMDAHLLRLLYNRDLQWRFANARADSTLMVQRLSAEKILWNAWVSISELRHSVTLKRIKLLLMRQKLKLASILKEQMCYLEEWSLLDRNHSNSLSGATEALKASTLRLPVSGKAVVDIQDLKHAVSSAVDVMHAMVSSIFSLTSKVEEMNSVMAEMVNITGKEEVLLEQCQGFLTRVAAMQVTDCSMKTHIIQLSRL
Protein: thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin Bcp) (C6XHE2)
Organism: Liberibacter asiaticus (strain psy62)
Interaction partners:
Sequence:
MTSLSVGDKAPHFVLPSNDEQEISLLALGGSKIVLYFYPKDDTSGCTAEAINFSSLKADFDEESTILIGISPDSIASHKKFHQKHNLSITLLADESKEVLKSYDVWKEKSMFGKKYMGVVRTTFLIDEKGIIAQIWKPVTLKNHAQSVLKMVKSLKQ
Protein: Uncharacterized protein YOL159C-A (Q3E769)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YPL261C
- Uncharacterized protein YHR086W-A
Sequence:
MQYCELDLSGQWLDTVYCEENFSDFVFIKFLNPSQFEEKIYCYTLHITKRTLENKRLLLYYEDEFKKHGHDINELVGDGIILRSCWNPRQ
Protein: NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (Q59P03)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P38626}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyb5p
- Cytochrome b5 heme-binding domain-containing protein
- Cytochrome b5 heme-binding domain-containing protein
- NADH-cytochrome b5 reductase 2
- NADH-cytochrome b5 reductase
- Dihydroorotate dehydrogenase
Sequence:
MSETTTVPPIETVSEPNPFIVFATVATIISAFIGYYFLQQSKKHTPVLKPDEFQKFPLIEKIRVSHNSAIYRFGLPKSTDRLGLPIGQHISIGATIDGKEVVRSYTPISTDDQLGHFDLLIKTYENGNISRHVAGKNVGEHIEIRGPKGFFTYTPNMVKSFGMIAGGTGIAPMYQIITAILKNPEDKTKIHLVYANVTESDILLKEELDNFAARHPDRLKIHYVLNEAPANWQGSVGFVTPEIIDTHLPKASNDTNLLLCGPPPMVSAMKKAAVELGFQKAKPVSKLGDQVFVF
Protein: RNA helicase (EC 3.6.4.13) (Q6DRN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDLIRTIDDDEEVPEEPDSGSDDEADQPIVLKSKEKQALKARGSGHFNADFDFGERDGLYSADWAMADVMAQLKKRKAPTTLDEKIEKVRKKRKVEEKSQKENKKTETSASKKHDDQEEEEEEEEDDEEEEEDNDADDNDADEVSGGGDDDDDDEDEFSSADEEVLKKADTLREKQKKGKRKMADTTEGFFEDASQYDENLTFHDMNLSRPLLKAISTMGFKQPTPIQKACVPVGLLGKDICACAATGTGKTAAFMLPVLERLIYKPRETQVTRVLVLVPTRELGIQVHTVARQLAQFTTISTCLAVGGLDLKSQEAALRAGPDVLIATPGRLIDHLHNTPSFELSQIEILILDEADRMLDEYFEEQMKEIIRMCAYQRQTMLFSATMSEEVKDLASVSLKQPVRIFVNSNTDVAPYLRQEFVRIRPNKEGDREAIVAALLTRTFQDHVMLFTQTKKQAHRMHILLGLMGLKVGELHGNLSQTQRLESLRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTVKHYVHRVGRTARAGKVGRSVSLVGETERKMLKEIVKKAKFPVKARVIPQEVILKFRDLIEKLEKDVYAVLCLEKEEKEMAHSEAQISSAQKRLTKSEDEKQLPRTWFQTNEERKKDRMAKALQDFDLALRGKKKRAQFLKQGKRKELTAEERAQLEVLKSQMFAERAAKRERKQKRARAIPEDQPDKKALKKNAGKAGKKSVFDKELTNTSKKNLKQYRAGPSFEDRKRLGLPNKKGGRFKSKAKFKRK