wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (DNA-damage-repair/toleration protein DRT101) (N-acetylglucosamine-phosphate mutase) (P57750)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Interconverts GlcNAc-6-P and GlcNAc-1-P.
Interaction partners:
- Glucosamine 6-phosphate N-acetyltransferase
- UDP-N-acetylglucosamine diphosphorylase 1
- UDP-N-acetylglucosamine diphosphorylase 2
- Glutamine--fructose-6-phosphate aminotransferase 1
- DNA damage-repair/toleration protein DRT102
- ADP-glucose phosphorylase
- ADP-glucose pyrophosphorylase family protein
- ADP-glucose pyrophosphorylase family protein
- Ornithine transcarbamylase, chloroplastic
- Probable mannose-1-phosphate guanylyltransferase 2
Sequence:
MDEIQIASILKSSELFPIPQGVKLSYGTAGFRGDAKLLESTVYRVGILSALRSLKLGSATVGLMITASHNKVSDNGIKVSDPSGFMLSQEWEPFADQIANASSPEELVSLIRKFMEKEEIAIGENNKGAEVWLGRDTRPSGESLLRAGEIGVGSILGSVAIDIGILTTPQLHWMVRAKNKGLKATENDYFENLSTSFRCLIDLIPSSGNDKLEISKLLVDGANGVGGQKIEKLRGSLSNLDVEIRNTGRDGGVLNEGVGADFVQKEKVLPVGFGFKDVGMRCASLDGDADRLVYFYIPSDSSEKVELLDGDKILSLFALFIKEQLNALEDDEERKQSRLGVVQTAYANGASTDYLKHLGLDVVFAKTGVKHLHEKAAEFDIGIYFEANGHGTILFSESFLSWLVSKQKDLTAKGQGGSEEHKAVSRLMAVSNLINQAVGDALSGVLLVEVILQHLGWSIEKWNELYKDLPSRQIKVEVPDRTAVVTTSEETEALRPMGIQDAINSEIKKYSRGRAFIRPSGTEDVVRVYAEASTQEDADSLANSVAQLVKSFLGSS
Protein: Histone-lysine N-methyltransferase SUV39H1-A (EC 2.1.1.-) (EC 2.1.1.366) (Suppressor of variegation 3-9 homolog 1-A) (Su(var)3-9 homolog 1-A) (Q6DGD3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as regulation of organ-specific terminal differentiation during development.
Subcellular location: Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.
Interaction partners:
- Histone H3
- Histone H3.2
- Histone H3.3
- Histone H3
- Si:dkey-108k21.24.
- DNA
- Lysine-specific histone demethylase
- Histone-lysine N-methyltransferase KMT5B
- Lysine methyltransferase 5C.
- Histone deacetylase 1
Sequence:
MARDLKDCRVPCKLLLEDLQALCRRKKLVCKQLSVTKNNFNDYEVEYLCNYKKHKGREFFLVKWKGYEESENTWEPLKNLKCPILLHQFRKDMKAALLQANEPLDSASLSGPIISFLRQKATQRIRLKKWEDLMNQTCWHKGRIFVSNEVDMDGPPKNFTYINENKLGKGVDMNAVIVGCECEDCVSQPVDGCCPGLLKFRRAYNESRRVKVMPGVPIYECNSKCRCGPDCANRVVQRGIQYDLCIFKTDNGRGWGVRTLQRINKNSFVMEYLGEIITTDEAEQRGVLYDKQGVTYLFDLDYVDDVYTIDAAHYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFAKRGIKAGEELTFDYKMTVDPVDAESTKMDLDFSRAGIEGSPIKRVHMECKCGVRNCRKYLF
Protein: Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) (H0YWU3)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
MQVSFVCSEHSIKSRSAEDRLNRQNAGSPSLGTRGKFRAVAMVARSLGQLSVQNAPSSSDSSVKQPGMKYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDGGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS
Protein: Interferon regulatory factor 7 (H0WFC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MQSTNAKPQFGPWLIEQVESGQYEGLSMIGHDIFRIPWKHNARRDLGDADVKIFKEWAIVSGKINEYPNDKAKWKTNFRCALHSLKSFEMLEDHSKDPDDQHKIYRIIRPQNHQEIKSAIQSAEAVQRQLPFIAEVYNASNHMSQDMELELLNLVETMDLNLHAVDQWNLDLEISISYRRTEVLKTRLCSSLIHFFYQCDPSELRGEQIRFPTTDCLIDVKQIQYTKRILDSIQRGLQLEVNQYGIYGFRQDKCKVFVSTSDPCEIQKPEPRKLQQNSKEQLLSFDKYIRDLLDFKENRGGSPDYTIYLCFGEKLHDGKPLEKKLITVKVVPLICRELHERAQMEGASSLRNDNVSLQISHNSLYDLINSLGLPSVE
Protein: U10-myrmicitoxin-Mri1a (U10-MYRTX-Mri1a) (A0A6G9KJK9)
Organism: Manica rubida (European giant red ant)
Function: Induces paralysis after injection into blowflies (L.caesar). In most cases is not lethal 24 hours after injection, but paralysis is irreversible. May have antimicrobial properties, like most ant linear peptides (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:32182430}.
Interaction partners:
Sequence:
MRLSYISLTIAIIFVMAIVHAPETEAKAYPEADAVAEAIAVGEADAVGVADPGFKSMLAKAALKILKAVAPAAAAAIADKIG
Protein: Plasma membrane proteolipid 31 (Meiotically up-regulated gene 75 protein) (O74837)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSNVTLSDFLLIVLSFFVPFIVVGIRRGFCTADFLINICLCALGIPGIIHAIYIVIKYPRTVRLDIENSPNDPLVRYTPNPEHAVSPHSGPAPPSYSSLASNDNKHQSP
Protein: A-kinase anchor protein 12 (AKAP-12) (Germ cell lineage protein gercelin) (Src-suppressed C kinase substrate) (SSeCKS) (Q9WTQ5)
Organism: Mus musculus (Mouse)
Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q02952}; Lipid-anchor {ECO:0000250|UniProtKB:Q02952}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Calmodulin-like protein 4
- A-kinase anchor protein 1, mitochondrial
Sequence:
MGAGSSTEQRSPEQPAESDTPSELELSGHGPAAEASGAAGDPADADPATKLPQKNGQLSAVNGVAEQEDVHVQEESQDGQEEEVTVEDVGQRESEDVKEKDRAKEMAASSTVVEDITKDEQEETPEIIEQIPASESNVEEMAQAAESQANDVGFKKVFKFVGFKFTVKKDKNEKSDTVQLLTVKKDEGEGAEASVGAGDHQEPGVETVGESASKESELKQSTEKQEGTLKQAQSSTEIPLQAESGQGTEEEAAKDGEENREKEPTKPLESPTSPVSNETTSSFKKFFTHGWAGWRKKTSFKKPKEDDLETSEKRKEQEAEKVDEEEGEKTEPAPAEEQEPAEGTDQARLSADYEKVELPLEDQVGDLEALSEKCAPLATEVFDEKTEAHQEVVAEVHVSTVEKMTKGQGGAEVEGDVVVEGSGESLPPEKLAETQEVPQEAEPVEELMKTKEVCVSGGDHTQLTDLSPEEKMLPKHPEGIVSEVEMLSSQERIKVQGSPLKKLFSSSGLKKLSGKKQKGKRGGGGGDEEPGEYQHIQTESPESADEQKGESSASSPEEPEEIACLEKGPSEAPQEAEAEEGATSDGEKKREGITPWASFKKMVTPKKRVRRPSESDKEEELDKVKSATLSSTESTASGMQDEVRAVGEEQRSEEPKRRVDTSVSWEALICVGSSKKRARKASSSDDEGGPRTLGGDGHRAEEASKDKEADALPASTQEQDQAHGSSSPEPAGSPSEGEGVSTWESFKRLVTPRKKSKSKLEERAEDSGAEQLASEIEPSREESWVSIKKFIPGRRKKRADGKQEQAAVEDSGPGEINEDDPDVPAVVPLSEYDAVEREKLEAQRAQENVELPQLKGAVYVSEELSKTLVHTVSVAVIDGTRAVTSAEERSPSWISASMTEPLEHAEGVATPPVGEVTEKDITAEATPALAQTLPGGKDAHDDIVTSEVDFTSEAVTAAETTEALRAEELTEASGAEETTDMVSAVSQLSDSPDTTEEATPVQEVEGGMLDTEEQERQTQAVLQAVADKVKEDSQVPATQTLQRAGPKALEKVEEVEEDSEVLATEKEKDVVPEGPVQEAETEHLAQGSETVQATPESLEVPEVTEDVDRATTCQVIKHQQLMEQAVAPESSETLTDSETNGSTPLADSDTPNGTQQDETVDSQDSNAIAAVKQSQVTEEEAAAAQTEGPSTPSSFPAQEEHREKPGRDVLEPTQALAAGAVPILAKAEVGQEGEAGQFDGEKVKDGQCVKELEVPVHTGPNSQKTADLTRDSEVMEVARCQETESNEEQSISPEKREMGTDVEKEETETKTEQASEEHEQETAAPEHEGTHPKPVLTADMPHSERGKALGSLEGSPSLPDQDKADCIEVQVQSSDTPVTQTTEAVKKVEETVATSEMDESLECAGAQSLPAEKLSETGGYGTLQHGEDTVPQGPESQAESIPIIVTPAPESILHSDLQREVSASQKQRSDEDNKPDAGPDAAGKESAAREKILRAEPEILELESKSNKIVQSVIQTAVDQFARTETAPETHASDLQNQVPVMQADSQGAQQMLDKDESDLQVSPQDGTLSAVAQEGLAVSDSSEGMSKASEMITTLAVESASVKESVEKLPLQCKDEKEHAADGPQHQSLAKAEADASGNLTKESPDTNGPKLTEEGDALKEEMNKAQTEEDDLQEPKGDLTES
Protein: Thiamine-phosphate synthase (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase) (TMP-PPase) (Q72AA6)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Hydroxyethylthiazole kinase
- hydroxymethylpyrimidine kinase
- Thiazole synthase
- ThiH protein
- ThiF family protein
- Thiamine-monophosphate kinase
- Thiamine-phosphate synthase
- Small ribosomal subunit biogenesis GTPase RsgA
- Phosphomethylpyrimidine synthase
- ThiH protein, putative
Sequence:
MPVILPGTTPDADIYCLTDSGLCLGRPTVDVVDAMLQAGARIIQYREKEKKAGEMLRECLELRRMTREAGACFIVNDHVDIAILCDADGVHIGQDDLPVGEVRRLIGPDRAIGLSTHSPEQAMAAVAAGVDYIGVGPIFATKTKKDVCDPVGYAYLDWVVTHLDIPFVAIGGIKLHNIGEVAAHGARCCALVSEIVGAVDIVAQVQTVRRAMRGVAAAGTDSPQAG
Protein: Glutaredoxin-C14 (AtGrxC14) (Protein ROXY 8) (Q9LYC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor SLU7-A
- Transcription factor TGA4
- Monothiol glutaredoxin-S13
- Transcription factor TGA1
Sequence:
MDKVMRMSSEKGVVIFTKSSCCLCYAVQILFRDLRVQPTIHEIDNDPDCREIEKALVRLGCANAVPAVFVSGKLVGSTNDVMSLHLSGSLVPLIKPYQSFHN
Protein: Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) (P97742)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in hepatic triglyceride metabolism (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P50416}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetyl-CoA carboxylase 2
- Long-chain-fatty-acid--CoA ligase 1
- Carnitine O-palmitoyltransferase 2, mitochondrial
- Long-chain-fatty-acid--CoA ligase 5
- Fatty acid CoA ligase Acsl3
- Long-chain-fatty-acid--CoA ligase 4
- Long-chain-fatty-acid--CoA ligase 6
- Carnitine O-palmitoyltransferase 1, muscle isoform
- Palmitoyl thioesterase CPT1C
- Peroxisome proliferator-activated receptor alpha
Sequence:
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPASPSSWLIVVVGVISSMHTKVDPSLGMIAKINRTLDTTGRMSSQTKNIVSGVLFGTGLWVAIIMTMRYSLKVLLSYHGWMFAEHGKMSRSTRIWMAMVKVFSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEGDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPIMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTVDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHVKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDTSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPIVGHLWEYVMATDVFQLGYSEDGHCKGDKNPNIPKPTRLQWDIPGECQEVIETSLSSASFLANDVDLHSFPFDTFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCNFVLAMMDPTTTAEQRFKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKYPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTANSKK
Protein: NAC domain-containing protein 96 (ANAC096) (Q9LS24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in the positive regulation of abscisic acid (ABA) responsive genes. Acts as a positive factor of ABA-mediated responses. Involved in the transcriptional activation of ABA-inducible genes in response to dehydration and osmotic stresses. Plays a positive role in both stomatal closure and water loss under dehydration stress conditions. Acts synergistically with ABF2 to activate the dehydration stress-response factor RD29A transcription. Binds to the consensus core cis-acting elements 5'-CGTA-3' and 5'-CACG-3' at the RD29A promoter. Involved in hypocotyl graft union formation. Required for the auxin-mediated promotion of vascular tissue proliferation during hypocotyl graft attachment.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:24285786}.
Interaction partners:
- ABSCISIC ACID-INSENSITIVE 5-like protein 7
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
- Low-temperature-induced 78 kDa protein
- F18B13.21 protein
- Glycosyltransferase
- MJK13.9 protein family protein)
Sequence:
MGSSCLPPGFRFHPTDEELIEYYLKRKVEGLEIELEVIPVIDLYSFDPWELPDKSFLPNRDMEWYFFCSRDKKYPNGFRTNRGTKAGYWKATGKDRKITSRSSSIIGYRKTLVFYKGRAPLGDRSNWIMHEYRLCDDDTSQGSQNLKGAFVLCRVAMKNEIKTNTKIRKIPSEQTIGSGESSGLSSRVTSPSRDETMPFHSFANPVSTETDSSNIWISPEFILDSSKDYPQIQDVASQCFQQDFDFPIIGNQNMEFPASTSLDQNMDEFMQNGYWTNYGYDQTGLFGYSDFS
Protein: Serine/arginine-rich splicing factor RS31 (At-RSp31) (AtRS31) (P92964)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for constitutive and alternative pre-mRNA splicing.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:14740228, ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:15686520, ECO:0000269|PubMed:23454656}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14740228, ECO:0000269|PubMed:15133128}. Note=In meristematic cells, no apparent accumulation in foci. {ECO:0000269|PubMed:14740228}.
Interaction partners:
- Serine/arginine-rich SC35-like splicing factor SCL30A
- Serine/arginine-rich SC35-like splicing factor SCL30
- Serine/arginine-rich splicing factor SC35
- Nuclear protein-like
- Serine/arginine-rich splicing factor RSZ21
- Serine/arginine-rich splicing factor RSZ22A
- Serine/arginine-rich splicing factor RSZ22
- non-specific serine/threonine protein kinase
- Nuclear cap-binding protein subunit 2
- Splicing factor U2af large subunit A
Sequence:
MRPVFVGNFEYETRQSDLERLFDKYGRVDRVDMKSGYAFVYFEDERDAEDAIRKLDNFPFGYEKRRLSVEWAKGERGRPRGDAKAPSNLKPTKTLFVINFDPIRTKEHDIEKHFEPYGKVTNVRIRRNFSFVQFETQEDATKALEATQRSKILDRVVSVEYALKDDDERDDRNGGRSPRRSLSPVYRRRPSPDYGRRPSPGQGRRPSPDYGRARSPEYDRYKGPAAYERRRSPDYGRRSSDYGRQRSPGYDRYRSRSPVPRGRP
Protein: Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] (Q2TA68)
Organism: Rattus norvegicus (Rat)
Function: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (By similarity).
Subcellular location: [Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane {ECO:0000269|PubMed:16778770}; Single-pass membrane protein {ECO:0000255}. Note=Detected at contact sites between endoplasmic reticulum and mitochondrion membranes. {ECO:0000250|UniProtKB:O60313}.; SUBCELLULAR LOCATION: [Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:O60313}.
Interaction partners:
- Metalloendopeptidase OMA1, mitochondrial
- Mitofusin-2
- Mitofusin-1
- Serine/threonine-protein kinase PINK1, mitochondrial
- Mitochondrial fission 1 protein
- NAD-dependent protein deacetylase
- Mitochondrial fission factor
- Mitochondrial dynamics protein MID49
- Mitochondrial fission factor
- FUN14 domain-containing protein 1
Sequence:
MWRAGRAALACEVCQSLVKHSSGVQRNVPLQKLHLVSRSIYRSHHPALKLQRPQLRTSFQQFSSLTNLSLHKLKLSPTKYGYQPRRNFWPARLAARLLKLRYIILGSAVGGGYTAKKTFDEWKDMIPDLSDYKWIVPDFIWEIDEYIDLEKIRKALPSSEDLANFAPDLDKIAESLSLLKDFFTAGTPGETAFRATDHGSESDKHYRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQDEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQGRLKDTENAIENMIGPDWKKRWIYWKNRTQEQCVHNETKNELEKMLKVNDEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFIDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKVKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Protein: Uncharacterized protein YcgB (P29013)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Serine/threonine kinase YeaG
- UPF0229 protein YeaH
- UPF0339 protein YegP
- Inner membrane protein YohC
- Outer membrane lipoprotein Blc
- Uncharacterized protein YhfG
- Universal stress protein B
- Uncharacterized protein YodD
- Uncharacterized protein YccJ
- Disulfide-bond oxidoreductase YfcG
Sequence:
MATIDSMNKDTTRLSDGPDWTFDLLDVYLAEIDRVAKLYRLDTYPHQIEVITSEQMMDAYSSVGMPINYPHWSFGKKFIETERLYKHGQQGLAYEIVINSNPCIAYLMEENTITMQALVMAHACYGHNSFFKNNYLFRSWTDASSIVDYLIFARKYITECEERYGVDEVERLLDSCHALMNYGVDRYKRPQKISLQEEKARQKSREEYLQSQVNMLWRTLPKREEEKTVAEARRYPSEPQENLLYFMEKNAPLLESWQREILRIVRKVSQYFYPQKQTQVMNEGWATFWHYTILNHLYDEGKVTERFMLEFLHSHTNVVFQPPYNSPWYSGINPYALGFAMFQDIKRICQSPTEEDKYWFPDIAGSDWLETLHFAMRDFKDESFISQFLSPKVMRDFRFFTVLDDDRHNYLEISAIHNEEGYREIRNRLSSQYNLSNLEPNIQIWNVDLRGDRSLTLRYIPHNRAPLDRGRKEVLKHVHRLWGFDVMLEQQNEDGSIELLERCPPRMGNL
Protein: Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) (O88908)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11071899}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 7-dehydrocholesterol reductase
- Delta
- Sterol O-acyltransferase 1
- Cytochrome P450 7A1
- Sterol 26-hydroxylase, mitochondrial
- Cholesterol 25-hydroxylase
- Cholesterol 24-hydroxylase
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Sulfotransferase 2B1
- Phosphatidylcholine-sterol acyltransferase
Sequence:
MQPKVPQLRRREGLGEEQEKGARGGEGNARTHGTPDLVQWTRHMEAVKTQFLEQAQRELAELLDRALWEAMQAYPKQDRPLPSAAPDSTSKTQELHPGKRKVFITRKSLIDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMTWVPMFLSTLLVPYQTLWLWARPRAGGAWMLGASLGCVLLAAHAVVLCVLPVHVSVRHELPPASRCVLVFEQVRLLMKSYSFLRETVPGIFCVRGGKGISPPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQVLGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRRARGVAMLGVFLVSAVVHEYIFCFVLGFFYPVMLMLFLVFGGLLNFTMNDRHTGPAWNILMWTFLFMGQGIQVSLYCQEWYARRHCPLPQTTFWGMVTPRSWSCHP
Protein: SLAM family member 6 (Lymphocyte antigen 108) (CD antigen CD352) (Q9ET39)
Organism: Mus musculus (Mouse)
Function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity). Promotes recruitment of RORC to the IL-17 promoter (By similarity). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity. Involved in regulation of autoimmunity. Isoform 3 may be suppressor of pathogenic T-cell proliferation.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Signaling lymphocytic activation molecule
- SH2 domain-containing protein 1A
- CD48 antigen
- Natural killer cell receptor 2B4
- CD226 antigen
- NKG2-D type II integral membrane protein
- SH2 domain-containing protein 1B
- Natural cytotoxicity triggering receptor 1
Sequence:
MAVSRAPAPDSACQRMVWLFPLVFCLGSGSEVSQSSSDPQLMNGVLGESAVLPLKLPAGKIANIIIWNYEWEASQVTALVINLSNPESPQIMNTDVKKRLNITQSYSLQISNLTMADTGSYTAQITTKDSEVITFKYILRVFERLGNLETTNYTLLLENGTCQIHLACVLKNQSQTVSVEWQATGNISLGGPNVTIFWDPRNSGDQTYVCRAKNAVSNLSVSVSTQSLCKGVLTNPPWNAVWFMTTISIISAVILIFVCWSIHVWKRRGSLPLTSQHPESSQSTDGPGSPGNTVYAQVTRPMQEMKIPKPIKNDSMTIYSIVNHSREETVALTGYNQPITLKVNTLINYNS
Protein: Ubiquitin C-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (AtUBP22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Q9LEW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of a deubiquitination module (DUB module) that specifically deubiquinates monoubiquinated histone H2B (H2Bub). Does not seem to be a component of the TREX-2 complex. Seems to act independently of the SAGA multiprotein complex. The DUB module is responsible for the major H2Bub deubiquitinase activity in Arabidopsis.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:30192741}. Note=Displays a rather patchy distribution forming a punctuated pattern in the euchromatin (PubMed:30192741). Does not localize in the heterochromatic chromocenters or nucleolus (PubMed:30192741). {ECO:0000269|PubMed:30192741}.
Interaction partners:
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 9
- SAGA-associated factor 11
- Transcription and mRNA export factor ENY2
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Transcriptional adapter ADA2b
- Transcription initiation factor TFIID subunit 6b
- SAGA-associated factor 29 homolog B
- Histone acetyltransferase GCN5
Sequence:
MSARISFLKNPDPCNHLSDYKLRYGTDGYKSFNNLFRCFNDARIKIKLQGIDIPRCSYCSVYQKRLYICLICRSISCSSHILLHTQLNKGHDIAIDVERSELYCCACIDQVYDSEFDEVVVSKQLFGLGMSVKSGADVVAVRSNKKRRLDSQLIIGSNFLVSPRDRREKWTFPLGLRGLNNLGSTCFMNAVLQALVHAPPLRNFWLSGQHNRDLCPRRTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFISLLDRIHENEGKSKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGSTSTTYDPFIDISLTLDSMNGFSPADCRKNRYSGGPSVNAIMPTLSGCLDFFTRSEKLGPDQKLNCQSCGEKRESSKQMSIRRLPLLLCLHVKRFEHSLTRKTSRKIDSYLQYPFRLNMSPYLSSSIIGKRFGNRIFAFDGEGEYDSSSSSSPSAEFEIFAVVTHKGMLESGHYVTYLRLKGLWYRCDDAWINEVEEEVVRGCECYMLFYAQETVIQKAHKELSYQVISMADAFPFADC