wanglab/gogpt-training-data huggingface dataset:
Protein: LIM domain and actin binding 1 (F8VQE1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE
Protein: Spectrin beta chain (A0A8I6ASR7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAQVPGEVDNMEGPAASNNNNPAARWESPDRGWDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASDGAELGPGLALDEWLPHLEVGWHKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVAVQAAEGLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMLTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREATERRQQTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTACQELGRSLLLNKSAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAVTEQVRPRPERQELADRAEELPRRRRSERQESTDQPEEAARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGLPAAVPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVNLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I6ADP3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEDEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLHDHRRPHAQQPPPPQQQDRSKPSYHAPEPKPHYDPADRAREVEDRFRKTNHSSPEAQAKQTGRGLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEGLSQSSDSKSEVPEPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAAKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCTIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Protein: Nuclear receptor subfamily 1 group H member 3 (C9JBS2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLG
Protein: Egalitarian protein homolog (Q17902)
Organism: Caenorhabditis elegans
Function: Part of a complex with bicd-1 and dlc-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells.
Subcellular location: Nucleus envelope {ECO:0000305|PubMed:20005871}. Note=Probably recruited to the nuclear envelope by unc-83. {ECO:0000305|PubMed:20005871}.
Interaction partners:
- Protein bicaudal D homolog
- Dynein light chain 1
- RING-type domain-containing protein
- Protein PNS1
- Carbohydrate kinase FGGY N-terminal domain-containing protein
- Cation/H+ exchanger domain-containing protein
- F-box domain-containing protein
- Protein nud-2
- Nuclear migration protein unc-83
- Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
Sequence:
MEEAKNMALLFFMDHLMQKNGRRTIHDLSCQFGARGFSEEMRNAVGTTQEGLTEFLQGHPSLFTVEGDQVILNGHNDLNAKNNPLLQSGIRSRNYEKEAVDFFVTKLTKFGPELQIKSLLGHRSQAAPEVRLVSGRHLKEFCEFLQSQVDYFVVEGDRVRLKNMPEPDENAIEMDDEGRPLAGVKAKQAAVEYLKSVLEQNEDQPIPLDQFYQNFCQRFSHTIRQDVATNPKELLQFLKLNRGLFFIRSNKVSLVKNRLNEDGSENGSDEGEETNNNGMFPLDQSALTRIHFVKALKPAQDLISRLWQDINNMEKKVVGLDLKTVTVGVDGEIFLSLGVIATTSQIGIFDLASSDVIILESGFKGILESEKVVKVIHDARRVASLLAHKYAVHMRNVFDTQVAHSLLQHEKFNKSLNEMRPISFINLQRVYYPQSIMLSDVTPRKMSMCPNWGVRPITEEFQLTIVEEAHCLLSALYQSLSNLIPVHLRGVFEDKCIEVNHPEVLLASPNRPPPQPFISSPYRASTRRDVRNGGSIMQSFSPAPYAAAPRPQMSDACTQTFSTGDIEVLNVFYE
Protein: Rhoptry neck protein 3 (Q8I4R5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Rhoptry-associated membrane antigen
Sequence:
MNKYWLYIAYVYLLLNILSKCNKIENNNNKVKNLTVYNNDIGQYFKKKDIQCKHHIEINQDSNHNEYSFLSLKASSIFNQYYVAKLINTLLYRGFHLNVYFHKNVAMYESFSRTNFFFYLTILNKKNVKKIVKIISKAERSSNKRKFNVFKKYLISEFDYPNFEIDDTVKNEMNQAILVYKKAKSDSYWSVMDALKKDGLLLARTFLSVSFVQSLRGIIGLINHKLIDLCFTNAYVFNHVASFDKLIMNNIFGVIMSYVFKSLLLFFYPLIIPFRGAFAFAISAFCITQLGKIVFAIYKNLRQLYRISYRKIYSIVLKVKLRNEPELKKYAMKLLYGDALIMITKIWKLSYVNVSEHLNGKNVYPILNNLFEKNLGTGFFDFSNSLFKYVMNYLEEINLLNAKSVDVEKELILNRHNFKLLLKILKITKKSLLYEESYMKISVANLLTKFYTLILVNIEHISKLNPKEHFYNDLDNEFKHIYQDQMFELFIQKISSDIVRKPFIKRNIGRIDKGSIELTLALIKVKLLHYKPTLNNPYSSLYFDENLKKQLNYAFKLIIIGSTSIIASLANYGERYGVLKQCPLDIVKNLNQQCEYVSFEIKKLIFPINIFVNLLIPLFLPYDDVLVDKNIIDEVKKFFNVIIDTDDSYLQKYMKTTINTIRKSKDLDINNVNYEEEMEKIVVQEAHKVIEEINKERRASFKFQDFVVKEDSVVLYNKSGIQYSFKFDHLNRKEDFMRIIGSYQFKNPIGYQTSQLVFEPQNNHIGSLMVGSNKNTFDGKLSVCHMCYKEDDDSLVVDAIFSILWSSGIDRFSAFIFASFIGAVKQTYHQGTSWKRALSNMAPTEFYEMHKIFMDKSVYGKEKSQNYFLKNIRKYRFQFSRGSFSRMFRTFLENSLNKINFFNSEEAIIILVMSTLYALYKNIEKFDIPLKETYKLYQQKLIESYYHVDKYSHHYETYTLNIRRKKYNALVKSEHEKAQEASQGEGKDEAENAELKKRVEKRINFNDIQLTMEDEVVRNTKYLQLELQAKPQEREKIIQYLTYKYKEIPNHEMFPHLPHQCYFLLYYNYEPFLEKNLHGLEGVVSKITRKSVLSRYLKNINLIQPEKTRFASIKLKDLINILCGTHMFLKKEHITFDEIYKYENSNDALKHLLIIVALLRIEKRTNRYSWTTYLTLQKQLDERKRYYDTPFKYLFLKISKVRRFYGSAKKKMLLGFGKKFKGVRFLNILRYTRFFEIMEYAESINEFYPYCYIKFEDVLTFSNVFYKFKYSLLRYTTSKQSVRNVVNNFNLSPQTTGNNENLLLRIYRFIELIIKKKYNVDIQHVRKDDKDFNRHAYNKNEYILNDIKFNPNIEQYLRQLTGFIKLLTDMKFTNFLFLRNLYYFVKFYAVTGDLTYSINNSSIYLCSRNYLEFILNSIIEFENFKKFMVKIKEKFDIEKYPIDPYNFQTECYSIDSVKTYRFFLSDLDKLKSYQDIENLQNVSSFYKDYLYMGLFYENLDVRNLNVYYNFNKKKNQDHKAHGSNVFLDGGLSLSKNMSFSDINDLSESIQNYLYLEKFLADSNIPSIPYQGFSVRRVNDGMHVTYNNRSTTPPLYKDNVLDQFELVGKSLISEYFQKVKCSFIQYPFNLYYWLVLNPGKPNISLSSKTGLIKEDDLIPKTVEEKLKEEEEHDIKIVENILSEDIFDFKDKSDDDQSTTADVLSTDTDDSETDAEKTSNNSNTLHKKETPAMKYNMNIAQDEINRQNDVSKNTTYAENNEYTSENITKPSDQNTENYGTKMPSPSFIQIDKVNQQDQQNDAHIESSKNTQENLNYDDNTNMYEENKNDKKNKKLNNNTKEISFLERRETNPIPFSSNMINEKNKEAHKEHYGNFNRPYNIYVPKKDIFRNFHLVVKVVHALISLNKFSMVSPDTILKKGIESMKKKHSLKMIKNINPFIHKMILDMNETIQKLKSDSEKAYGGPKADIISLYKIVEFQLFNQYIIYPPLKRLTKKELKYILDVVNQGYYFYLKNVITKLKRENLQKSKVVKIFNNFQEFSNLLDDDGVDKLYNIFTETFKCKNIKCFDLLFQGFLTEQYNNIVYRYTHDHDAMNSYNDNIFNNKELLNKIFRRAYDNYFITPVKNNQPKKLISLEKPSLEQPVLTLEEFAYGFHEFGNKIEKWRSMLTLFNIRHIYINICHMLLSVKHSIQRSHRVFMHKFGFFGIFRRKREIYIP
Protein: Neurexin-3-beta (E1B6S7)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MGDTITTTMQAATVTDFPRTPLIMCSSLAVIIAIAAVVFFVFKCRQNPPNSEHYTMAMKSQSGYTAIAPELSPPMNHDRSNDSCTQPLLAKPHINGNGYEPLKGAVIANGNGATATMMRNGNGNGVAKKKDFKEWYV
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (F1LTH9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Flap endonuclease 1
- X-ray repair cross-complementing protein 6
- X-ray repair cross-complementing protein 5
- DNA replication ATP-dependent helicase/nuclease DNA2
- DNA repair protein RAD52 homolog
- DNA topoisomerase
- Exonuclease 1
- RNA helicase
- Replication protein A subunit
- Replication protein A 14 kDa subunit
Sequence:
METTSLRRKFPEWMSTQNKSCATQEKASIQKSVLEDDLPFLEFTGSVVYSYEASDCSFLSEDISMHLSDGDVVGFDMEWPPIYKQGKRSRVAVIQLCVSESKCYLFHISSMSVFPQGLKMLLENKSIRKAGVGIEGDQWKLLRDFDVKLESFVELTDVANRKLKCAETWSLNGLVKHVLGKQLLKDKSIRCSNWSDFPLSEDQKLYAATDAYAGLIIYQKLENLGDAVQVFALNKAEESLPMEMKKQLNSISEEMRDLANHFPVTCRNLETLQRVPMILENISENLCSLRKVICASTDTGTKLEPGGGSHLLSSEGSAAVGEKEKQMGEHRTFPKIKEEAWDPELDSLVKHEAVDVFRKQVKQEKGGFEDEMEDSLLREVMERTCLMPSISEYDLQDLEQQAKEEKHNAISHQFSEHLSPDDDEKDSSYIIESDEDLEMEMLKSLENLNSDVGEPTHSKWLETGGSVNLPPEEEDGDGKEAFEEEQEEEDHLLPEPNAKQINCLKTYFGHCSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLISLMEDQVLQLEMSNIPACLLGSAQPKNILGDIKLGRYRIIYITPEFCSGNLDLLQQLDSNIGITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPVIALSATASSSIREDIIRCLNLKDPHITCTGFDRPNLYLEVERKTGNILQDLKPFLVRKTSSAWEFEGPTIIYCPSRKVTEQVTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEIQCVVATIAFGMGINKADIRKVIHYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTTRNRLIEIHNEKFRLHKLKMMVKMEKYLHSSRCRRQIILSHFEDKRLQKASLAVMGTEKCCDNCRPRLNHCSSANNSEDTAQDFGPQAFQLLSAVDILQEKFGIKIPILFLRGSNSQRLPEKYHNHRLFGAGKEQAESWWKALSHHLIAEGFLVEVPKQNKFIKTCSLTKKGRKWLGEAILQSPPSLVLQADEEAFSRKALLSSSNPVSSETKPHSSNQKPTGSSTQQSNLEGAYSDKVPEKFSSGSNIPKKSVVMQSPGTSYSSWEPVISAQEVDTRTVLYARLVEARQKHANEVDVPPAVLATNKVLLDMAKMRPTTVENVKQIDGVSEGKAALLAPLTEVIKHFCQVNSVQTDLFASTKPQEDEEKSQEMENKACSLPQSAAVTYALFQEKKMSLHSIAENRLLPLTAVGMHLAQAVKAGHPLDMERAGLTPETRKIIMDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMMIEILESGSHGRTQPSCDSNRKRCLPSPAESCGSFKKSKEMVTETKAPSEMSQRKLPEWFVKGNVPLAATGSSSMAKTKKKGLFS
Protein: Ankyrin 3 (A0A087WZ65)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
XPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGYPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSEYPQYLGNLAGSPKDVKPAEPRKLGVSSEQQEKGKSGPDEEMMEEKLKSLFEDIQLEEGVESEEMTEEKVQAILKRVQQAELEMSSITGWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKDLKDSESDSSSEEERRVTTRVIRRRLIIKGEEAKNIPGESVTEEQFTDEEGNLITRKITRKVLRRIVIPQERKRDDVQGEGFKVKTKKEIRHVEKKSHS
Protein: Uncharacterized protein (Q57ZM3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKQKNVEINYDEVDETTGFKAAEMFVWLKFEESYLQKPEDEREADVDAWADTFCEEMEGEGMNYDRNFVRSVCTLGIYAGLRDEFQQRTGSGKAIYANGDRYDGEFFEGKKHGRGRYIFVSLGKSECDRIVEKELQKLGDVVAGENFVKAVADRYKIGCHIISYIIEYGFHPCYHGDYVRGKRVGRGLMKNKDGTVYKGEFLENKREGRGMFFYLNGDIYSGNWKNGRKHGYGTYHFVGGNEYRGMWNDGVFTHGQWIFPDGVYYEGHFNKKNRPCDEAASMHYPALKMAQTGTFKRGTWAPTSALEVCEETPVDGMTWTD
Protein: FI06792p (Pallbearer) (RE55455p) (Q9VT01)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO01111p1
Sequence:
MNLLDLPQTLIQDILELLPYDEVAKKREVCTLFNYLGQQILNKGFNKIIMAHAKNFKRIKSMLPRRESERRNHILSRHSDILTSIETRISMLTMTYSKFIDLNICCFIPGRVLDEINSILRILSTSTKQLRPHEVLQELRDISSMAIEHFDEKIAVNFKLEHRKQLAESTAAGARLVVCSALGDISFSGVRRTGISRPVDHGLVQQAIVQLAPISASKSHSDSSQKDRMSKQLFKQYQLQRSLSQKIRLLEVSRKVQDRRLQEALSSITELTTQVSELKRQMEDVVANMPSCAVKRQAVASADCLPPALKKPKV
Protein: ATPase get3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Golgi to ER traffic protein 3) (Guided entry of tail-anchored proteins 3) (Q4WY07)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03112}. Endoplasmic reticulum {ECO:0000255|HAMAP-Rule:MF_03112}.
Interaction partners:
- Protein get1
- Golgi to ER traffic protein 4
- UV excision repair protein RAD23
- Uncharacterized protein
- Heat-shock protein cognate
- Zn
- Uncharacterized protein
- ER-Golgi SNARE complex subunit
Sequence:
MSSTAVVHGDDLMEPTLQSILSQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGDSQGDDPLAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHAIVVNQLLFPKEGSGCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVHPYVPPQ
Protein: Serine/threonine-protein kinase pink-1, mitochondrial (EC 2.7.11.1) (PTEN-induced kinase 1 homolog) (Q09298)
Organism: Caenorhabditis elegans
Function: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Transmembrane GTPase fzo-1
- Mitochondrial Rho GTPase 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Beclin homolog
- Mitochondrial import receptor subunit TOM7 homolog
- Probable voltage-dependent anion-selective channel
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy-related protein 5
- FIS1-related protein fis-1
Sequence:
MSMKRFGKAAYRIANELVAKGGRLPIFQRFLPRIFPATYNLGVHVVLKKAPFPRQNALRIARLVTRHGRVFRPFSSVIIERHRFQNQNDWRRKFQPIRKELPRNVDLVERIRQIFGNSLRYNEDLKSTEWPNRIDSYEFGEFLGQGCNAAVYSARLANSDAESSGNTHYGAGFNEVTNILAEIPPVSKVAQKKFPLAIKLMFNFEHDRDGDAHLLKSMGNELAPYPNAAKLLNGQMGTFRPLPAKHPNVVRIQTAFIDSLKVLPDAIERYPDALHTARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGRVIIAQLLEACTYLHKHKVAQRDMKSDNILLEYDFDDEIPQLVVADFGCALACDNWQVDYESDEVSLGGNAKTKAPEIATAVPGKNVKVNFEMADTWAAGGLSYEVLTRSNPFYKLLDTATYQESELPALPSRVNFVARDVIFDLLKRDPNERVKPNIAANALNLSLFRMGEDVKQMMEKCGISQMTTLLAGSSKVLSQKINSRLDKVMNLITAETIMANLAPHLISRAERQLRATFLSRMNREDIWRSLQYFFPAGVQLDTPATSSDCLETISSLMSSFSNDSENYEKQQKPAKNGYNNVPLLLRNVIRTDADGINGIVHRVRSK
Protein: CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Protein ETR-R3) (Neuroblastoma apoptosis-related RNA-binding protein) (rNapor) (RNA-binding protein BRUNOL-3) (Q792H5)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O95319}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0H4}. Note=Accumulates in the cytoplasm after ionizing radiation. Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments (By similarity). {ECO:0000250}.
Interaction partners:
- CCAAT/enhancer-binding protein delta
- Muscleblind-like splicing regulator 1
- Heterogeneous nuclear ribonucleoproteins C1/C2-like
- Heterogeneous nuclear ribonucleoprotein C
Sequence:
MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSSTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
Protein: Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S] (P0A707)
Organism: Escherichia coli (strain K12)
Function: One of the essential components for the initiation of protein synthesis.IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:330233}.
Interaction partners:
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein bL35
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS2
- Threonine--tRNA ligase
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS3
Sequence:
MKGGKRVQTARPNRINGEIRAQEVRLTGLEGEQLGIVSLREALEKAEEAGVDLVEISPNAEPPVCRIMDYGKFLYEKSKSSKEQKKKQKVIQVKEIKFRPGTDEGDYQVKLRSLIRFLEEGDKAKITLRFRGREMAHQQIGMEVLNRVKDDLQELAVVESFPTKIEGRQMIMVLAPKKKQ
Protein: Proton-coupled folate transporter (Heme carrier protein 1) (Solute carrier family 46 member 1) (Q05B81)
Organism: Bos taurus (Bovine)
Function: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (By similarity). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (By similarity). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (By similarity). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells. Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:17335806}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q6PEM8}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (By similarity). {ECO:0000250|UniProtKB:Q6PEM8}.
Interaction partners:
- Folate receptor alpha
- Reduced folate transporter
- Bile salt-activated lipase
- Folate receptor alpha
- Dihydrofolate reductase
Sequence:
MEGRANSPGEPRAWPTRSVLCRGCVEPLVFLANFALVLQGPVTTQYLWHRFSADLGYNGTRHRDSCSNHSVDPIAQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDCVGRRPLLVLASLGLLLQTVLSIFVVQLHLHIGYLVLGRILCALLGDFSGLLAASFASVADVSSSRTRTIRMALLEACIGVAGMLASFIGGFLLQEQVYVNPFWLALAVLTVMTLYAAFCFGETVKERTPTRLFTLRHHRSVIQLYVTQAPEKSRKHLALYSLAIFVMITVHLGAQDILTLYELSAPLCWDSRLISYGSAAQQLPYLTSLLGLRLLQYCLADTWVAEIGLVFNILGMMVFAFATITPLMFTGYGLLFLSLVVTPIIRAKLSRLVRQSEQGALFSALACVNGLAMLMASGIFNSLYPATLNLMKGFPFLLAAGLLFIPAILMGILERDNHCPEFQEFSQSP