Protein: CCR4-NOT transcription complex subunit let-711 (CCR4-associated factor let-711) (Lethal protein 711) (Negative regulator of transcription subunit 1 homolog) (NOT1) (Q20937)
Organism: Caenorhabditis elegans
Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Positively regulates the accumulation of the CCR4-NOT complex component ccr-1. Within the complex promotes germ cell development and fertility in hermaphrodites. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity). Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs (By similarity). Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex (Probable). Acts as a transcriptional repressor (By similarity). Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity). In embryos, plays a role in female pronucleus and mitotic spindle positioning during the first cleavage divisions after fertilization. This may partly be through negatively regulating the accumulation of zyg-9 at the centrosome. Negatively regulates the formation of long astral microtubules in developing embryos. Required for the stabilization and degradation of maternal mRNAs such as nos-2 in somatic blastomeres.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A5YKK6}.
Interaction partners:
- poly
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 7
- Not3 domain-containing protein
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- CCR4-NOT transcription complex subunit 11
- ATP-dependent RNA helicase cgh-1
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- CCR4-NOT transcription complex subunit 4
- Protein PAT1 homolog 1
Sequence:
MHSTSGLAPVFRVEENHMIRNRENLERPISKKGTITLLSKMPMGFVLNSCSCAYIDNLLAHSSIHRVKPHSFMIQRLVVICGRSSPSLPNHAANIILSAFNFCQIEAPAKKFLEEDAALSLFHTILSYSTVTQINRSGIEILGAQRLTSALCDLIYAYTKTMDDMVASKTLTHLCKKLAGLFDPLVVLPFISKLAKSRRLRHYLQPLFLGHCEYTSDTWGVSPEGAEIYNQIARGNFTTQTLIEIVQTFLEKEVKEVIISSTTDPIKLVQYLISCSNPDNTEIVQALAFLLYSNTKLLPAGSGGTIDMDVQAADTITTARLGDTKFTQPVKDALLDSGREALLRRMEIYGVSLLSSVENFVTELKQAPIQKKMVTNNSVANAILYMLQYNFDMSRDIENGRQDNSPFWGGSNFVIGITRFVEEQQAAVRDMEGFSDWYPDINWVEVIKEFDSEEFAICRQTIIMFADIFPIMFQPQNFPVSFFLTPWRYYDHQLRLFEFMIEYADVWNISQYPHTKVLTPDLNLKTIPDDSTSVVQLWNCQEFSNCLLTIANSQPSLYNAIKQFYNVGSMQAGDVSMLALILSPTQWTTGRQDLIRHFLPSFILKSPNVTPVLNLVWNDTSLSKHMRQHVIYCLTSMHAADSSQLAKILDVAHDIKPTGLSELLNQAPKHLAFMVDLACLASKRDYLNLEKWIEDKEKAHGEAMTVAVLQFIQKKYQHAQLVAAIAPKTQATTPGAPSEPLQVLIPFVSKRARKPLRQQFPLVFQVMKENSGRSSSVSSGGHVQQSSGSQPQQQQFGGGSGLPPSGVVPVQQQPQQPPSLQQQHSQQSLPTPPTTSQQQIHVQQSVPGPIQRPAQFAPQPMFPPQAQAQHQHQHMMGQPPPSSQNAQPGMNLLMNMSPFASGNNRDLLKVVQPAPPPPSSMSPSTQMMRSLIPPLTQRQNSNSGWHAAPAPQRPSGPPTPQQQMDFRGQIQEFAPQGPHQLQRSGSVTGRSMGIVGQKTSSNFSVGAPIPGSAAATAAAAANVQQPMNEDFQSMTFAEDIQEEANSYFEKIYSVNNAMSVENLIDLLKRFRVSNDRRERLVLACVVKNLFEEYRFFHEYPERELRTTAAVYGGIIREDIISNVQFATAVRKVIESLSADPNTMLWTFGIVALQHCRSKLCAYPKVCQMIVSSENFARFPQLLKDYVIAGVKGELPPEGGRHTPVGSAQAGSASSTPTPAAAPTNWGAVARAASVDPKNSLPANRTGNVLSYTNVDTLVMATNKDGAEIAQPAEAIVDKISFLFNNLSQSNLIQKKDEVVEMISDHGDAFTLWLAQYIVMKRVSIEQNFQPLYNQFVNAIENPYLDQCIKRETFRNIRILLRTDKRTTVASNYSDRQLLKNLGSWLGAITIARNKPILLNDLDLKSLLLEAYYKGQAELLYVVPFISKILTACSKTSLFTPTCAWIRSILKVLAELHNEPDLKINLKFEIEVLCKELNVDLNQLQMDGILKDTEKLVRVPQQLCDVKLLTRPEAASPVQSKIHMSGSAEQLSGMSPAIPDQVKPATPQPTEAELQSGTGGGGSQGAEAQVVPNVTHFAYHDINVLTYDGLIPHVKIVSHLPLFQLHPHAKHLVRPAMIHAIKELIGPVTERALKIAMTVTESLVRKDFALDPEEQNLRAASFHMMRAMTAGMAMITCRDPLASSMHSNLANAFSSSLRSTAANPEMKQMIEDAAATITQDNVELSTNFIVKTACEKATQDIEKRLEADYQKRIAAKAEMSFYRDEIAAAIHAQLPKAIATVPGPTDKALMGIYDQFSSRICGFKANSGEDPVSAEPGSGAITPVQTQSKEMELVCQQLQVIIKEVDQTTQAQPHLSNSAFQTVCLMRELMQNVISTKDANHLMILVTRSTEHLLHAYRLEGTPPKNLLDVEWARRLRDLFIGLMRLLQNYFPLVELSRRITTAIMQIRSDYKWNMEGIEILFKQNLLQSVLWDQHLAGSMDNGGNMEAVLFAQKFVRSIGGGDMSRIQFLKERFPLTCEQLTKLHQLQSATRTEGMNNAMNNGAGNAAHHHAGLQQQPPVALPMEAAPMPQASADAMAQRGYDDQEMTAKVEIIMREWIGLCYSPTGQRSPQESLAQMIQLMHEHGVLATDDKITQFFRLCVENCVDISVRVMKSEQLANGLPTTLIRHRCYYTLDAFVKLMALMIRHSDNGQSQNKINLLKKLLNIIVGVLHMDHEVRKQDFNAMPYHRILISLFNEITGPDPLKLLEPIAWSILEAFGQTFFALQPRRMPGFAFAWLDIVGHRNVIGRLLANTGIAETVDAVKTAATYTQLIISHLKFLAPFLRNIQLPKSIAILYKGTLRVLLVILHDFPELLCEFHYVICDTIPPNCVQLRNLILSAYPRQMRLPDPFALNFKQVDTIPEMAVEPKSNLNMATIIPDNIRIPLDEYLANRISVDFLPNLPTLLQTQNQAGTKYNTTVMNALVLYVGIRAIEHLHLRRQRISTLNIAHTSYMDIFQNLAIQLDTEGRYLLFNGIANQLRYPNAHTHYFSCVFLYLFKNSTNDTIQEQITRILFERLVALRPHPWGLLITFIELIKNPTYNFWRYEFTSCAPEIQRLFQNVANTCVPAQGSQPQAQPDGAPGPLGNNTGAANQQQNPNTN