wanglab/gogpt-training-data huggingface dataset:
Protein: Secreted frizzled-related protein 2 (sFRP-2) (Protein SDF5) (Secreted apoptosis-related protein 1) (SARP-1) (P97299)
Organism: Mus musculus (Mouse)
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Subcellular location: Secreted.
Interaction partners:
- Protein Wnt-3a
- Protein Wnt-2
- Protein Wnt-5a
- Protein Wnt-7b
- Proto-oncogene Wnt-1
- Protein Wnt-2b
- Protein Wnt-11
- Dickkopf-related protein 1
- Protein Wnt-4
- Protein Wnt-6
Sequence:
MPRGPASLLLLVLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDHLLPATEEAPKVCEACKTKNEDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRKLQC
Protein: Cell division cycle protein 20 homolog (p55CDC) (Q62623)
Organism: Rattus norvegicus (Rat)
Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Interacts with NEK2 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q12834}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q12834}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q12834}.
Interaction partners:
- G2/mitotic-specific cyclin-B1
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Securin
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- F-box only protein 5
- Serine/threonine-protein kinase PLK1
- BUB3 mitotic checkpoint protein
- Cell division cycle protein 27 homolog
- Cyclin-A2
- Mitotic spindle assembly checkpoint protein MAD2A
Sequence:
MAQFVFESDLHSLLQLDAPIPNAPIARWQRKAKEATGPAPSPMRAANRSHSAGRTPGRTPGKSNSKVQTTPSKPGGDRYIPQRSASQMEVASFLLSKENQPEDGGTPTKKEHQKAWARNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKACRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMTSHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGESGWVPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTARVLSLTMSPDGATVASAAADETLRLWRCFELDPALRREREKASTSKSSLIHQGIR
Protein: 13.3 kDa protein (E4 orf 4) (Q6VGT1)
Organism: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Interaction partners:
Sequence:
MVLPALPAPPVCDSQNECVGWLGVAYSAVVDVIRAAAHEGVYIEPEARGRLDALREWIYYNYYTERSKRRDRRRRSVCHARTWFCFRKYDYVRRSIWHDTTTNTISVVSAHSVQ
Protein: A-kinase interacting protein 1 (cDNA FLJ55419, highly similar to Proline-rich protein BCA3) (B4DGE2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLEKQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPVSTELLTHWVSPPLQLHEPVDMVLRGLFELSL
Protein: NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) (Q0X0E5)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20070}; Lipid-anchor {ECO:0000250|UniProtKB:P20070}; Cytoplasmic side {ECO:0000250|UniProtKB:P20070}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P20070}; Lipid-anchor {ECO:0000250|UniProtKB:P20070}; Cytoplasmic side {ECO:0000250|UniProtKB:P20070}.
Interaction partners:
- Cytochrome b5
- Sulfite oxidase.
- Dihydropyrimidine dehydrogenase [NADP
- Dihydroorotate dehydrogenase
- Uridine monophosphate synthetase.
- Uncharacterized protein.
- Iodotyrosine deiodinase.
Sequence:
MGAQLSTLGHVVLSPVWFLYNLLMKLFQRSTPAITLESPDIKYPLRLIDKEVINHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVIRPYTPVSSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMKIGDTIEFRGPNGLLVYQGKGKFAIRPDKKSNPIIKTVKSVGMIAGGTGITPMLQVIRAIIKDPHDPTVCHLLFANQTEKDILLRPELEELRNEHSARFKLWYTVDKAPEAWDYSQGFVNEEMIRDHLPPPEEEPLILMCGPPPMIQYACLPNLDRVGHPKERCFAF
Protein: Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (mSMC6) (Q924W5)
Organism: Mus musculus (Mouse)
Function: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11408570}. Nucleus speckle {ECO:0000250|UniProtKB:Q96SB8}. Chromosome {ECO:0000269|PubMed:11408570}. Nucleus, PML body {ECO:0000250|UniProtKB:Q96SB8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96SB8}. Note=Localizes to PML nuclear bodies in ALT cell lines. Associates with chromatin. Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. Localizes in interchromatin granule clusters (By similarity). Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (PubMed:11408570). {ECO:0000250|UniProtKB:Q96SB8, ECO:0000269|PubMed:11408570}.
Interaction partners:
- Structural maintenance of chromosomes protein 5
- E3 SUMO-protein ligase NSE2
- Non-structural maintenance of chromosomes element 1 homolog
- Non-structural maintenance of chromosomes element 4
- Non-structural maintenance of chromosomes element 3 homolog
- EP300-interacting inhibitor of differentiation 3
- Structural maintenance of chromosomes protein 3
- PAX-interacting protein 1
- Mediator of DNA damage checkpoint protein 1
- Small ubiquitin-related modifier 3
Sequence:
MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTSTLTAAEVGIIESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQQVRLNDAEKKYKDIQDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQEHTVNQEAEQFEQAIEKDKQEHGRVRKEDIEVRHALNYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRPQIIVSEFRDEVYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIENKKGHIITLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQSVDIATLEDEAEENKIKMQMVEKNMEQQKENMENLKSLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQHYEDKQKEHLDTLNKKRRELDMKEKELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDLDNKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDSAS
Protein: DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) (Q90YB1)
Organism: Gallus gallus (Chicken)
Function: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P49917}.
Interaction partners:
- X-ray repair cross-complementing protein 5
- DNA-dependent protein kinase catalytic subunit
- X-ray repair cross-complementing protein 5
- Non-homologous end-joining factor 1
- DNA repair protein RAD52 homolog
- DNA repair protein XRCC4
- Protein artemis
- Uncharacterized protein.
- Uncharacterized protein.
- Tyrosyl-DNA phosphodiesterase 1.
Sequence:
MASAPVLQPSPKRTVASHVPFADLCSTLERIQTCKSRPEKTKYFKDFLDSWRKFHSALHQKEKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPKDGKDAVKLLNYRTPTGSRGDAGDFAMIAYFVLKPRSPKRGRLTVEQVNELLDAIANNNAAKNKGLVKKSLLQLITQSTALEQKWLIRMIIKDLKLGVSQQTIFSIFHPDAAELHNVTTDLEKVCRQLHDPSVSLSDVSIMLFSAFKPMLAAIADVQQIEKQMNNQVFYIETKLDGERMQMHKDGDVYKYFSRNGFDYTQQFGASPVDGSLTPFIHNVFKSDIQNCILDGEMMAYNPETQTFMQKGNKFDIKRMVEDSDLQTCFCVFDVLMINDQKLAHESLSKRYKILSNVFTPLTGRIHVVHKKSARTRKEVIDALNEAIDNREEGIMVKDPMSTYKPDKRGEGWLKIKPEYVNGLMDELDLLIVGGYWGKGSRGGMMSHFLCAVAETPAPNEKPTVFHSICRVGSGYTMKELYDLGLKLAKHWKPYNRKDPPCNILCGTEKPEMYIEPCNSVIVQIKAAEIVNSDMYKTDCTLRFPRIEKIREDKEWYECMTLDMLEHLRSRAEGKLASKHLYIDEYDEPQEKKRRTVPKVKKVIGIAEQFKAPDLSNVNKVSSMFEDVEFCVMTGMGRYSKSELESRIAECGGSVVQNPGPDTYCVIVGAENVRVKNIIASNKYDVVKAEWLLQCFQSKMLVPWQPAFMIHMSPETREHFAREYDCYGDSYTADTDVAQLKEVFSRVKDNKKMPLDLIAELEERYSWNSCKLCIFRGNTIYVDYYAIINKPSTKIHGTRLSIRALELRFYGAKVVPLLEEGVSHVVIGEDHSRVKEMKALRRMFGKKFKIVSELWVTESVKEGVPKNETQFLI
Protein: Olfactory receptor 5AR1 (Olfactory receptor 1019) (Olfactory receptor 180-1) (Q8VGS3)
Organism: Mus musculus (Mouse)
Function: Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:29659735}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MDKENHSVVTEFVFMGITQDPQLQIIFFVVFLLVYLVNVIGNVGMIILIITDSQLHTPMYFFLCNLSFVDLGYSSAIAPRMLADFLTKHKVISFSSCATQFAFFVGFVDAECYVLAAMAYDRFVAICRPLHYSTLMSKKVCLVLMLGSYFAGLVSLVAHTSLTFSLSYCGSNIINHFFCEIPPLLALSCSDTYISEILLFSLCGFIEFSTILIIFISYAFILIAIIRIRSAEGRLKAFSTCGSHLTGVTLFYGTVMFMYLRPTSSYSLDQDKWASVFYTIIIPMLNPLIYSLRNKDVKAAFKKLIGKKPQ
Protein: Polynucleotide kinase 3'-phosphatase (A0A8I6AJP5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSELGSRGRLWLQSPTGGPPPIFLPSDGQALVLGRGPLTQVMDRKCSRNQVELIADPETRTVAVKQLGVNPSTVGVQELKPGVSGSLSVGDVLYLVNGLYPLTLRWEEISTPGSPPDTPPGNPVDPEEGKDTEPQKKRMRKSSPGWESFKQLLVFTASGVKPRGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKVLVATHAGLNRKPVSGMWDHLQEKGNEGIPISIGDSVFVGDAAGRPANWAPGKKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSFLLSPNPEVVVAVGFPGAGKSTFIQKHLVSAGYVHVNRDTLGSWQRCVNSCQAALRQGKQVVIDNTNPDIQSRARYIQCAKDAGVPCRCFSFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLEILQVPFRLQEHLDPALQRLYCQFSEG
Protein: Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase 1) (IDH 1) (IDP 1) (NADP(+)-specific ICDH 1) (Oxalosuccinate decarboxylase 1) (Q75JR3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable cytoplasmic aconitate hydratase
- Probable aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase regulatory subunit B, mitochondrial
- Isocitrate dehydrogenase regulatory subunit A, mitochondrial
- Glutamate dehydrogenase, mitochondrial
- Glutamate dehydrogenase 2
- Dihydrolipoyl dehydrogenase, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
Sequence:
MVEKIIVSNPVANLLGDEQTRVIWDLIEKKLIFPFLDLKVETYDLGIEYRDKTNDQVTIDAANAIKRLKVGIKCATITPDEARVTEFGLKEMWKSPNGTIRNTLGGTLFREPIVCKNVPRLVTCWNKSIVIGRHAFGDQYRATDFVVKGAGKLELTYTPADGSAPQKFQVFDFPSDGGVALGMYNTDASIKEFAYACFNFSLDKKWPLYLSTKNTILKRYDGRFKDIFQEIYEREYKVKFDTAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDAVAQGYGSLGLMTSVLLSADSLVAEASHGTVTRHFREHQKGRETSTNSIASIFAWTRGLEYRAKLDNNDKLLKFCHALEASCIDAVESGFMTKDLAICVKGSVENVKRTDYLNTEEYINKVAELLVSKLTAL
Protein: Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) (Q91XC9)
Organism: Mus musculus (Mouse)
Function: Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:Q9Y5Y5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y5Y5}.
Interaction partners:
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisomal membrane protein 11B
- Peroxisomal ATPase PEX6
- Peroxisomal targeting signal 1 receptor
- Peroxisomal membrane protein PEX14
- ATP-binding cassette sub-family D member 3
- Peroxisomal targeting signal 2 receptor
- Peroxisome biogenesis factor 10
Sequence:
MEKLRLLSLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMLLLIWFKAGIQTSPPIVPLDRETQAQPLDGDHNPGSQEPSYVGKRSHRVVRTLQNSPSLHSRYWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWTPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLTDHIPGVGLVARPLMDYLPSWQKIYFYSWG
Protein: Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (Q07879)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule.
Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:17295840}; Peripheral membrane protein {ECO:0000269|PubMed:17295840}.
Interaction partners:
- Ubiquitin-like protein ATG12
- Ubiquitin-like modifier-activating enzyme ATG7
- Putative lipase ATG15
- Autophagy protein 16
- Cysteine protease ATG4
- Autophagy-related protein 3
- Autophagy-related protein 8
- Autophagy protein 5
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 14
Sequence:
MIPYQEWHSQLQSLYDSQIFHNWALCQDVHLNDEKDGLLLRLIPTRQLQKNTERIENKLLNHIELYLTYSKVYNEPLLLLRIWEEKSIDGIPMTKLMLPTDIESLLDVQGKFQLGLDTIINLEGSVWYSFHPCDTSCIVGDQAEFMSTYLRRWVSIFIFSWLGYEDS
Protein: Endoribonuclease dcr-1 (EC 3.1.26.-) [Cleaved into: Death-promoting deoxyribonuclease (tDCR-1) (EC 3.1.21.-)] (P34529)
Organism: Caenorhabditis elegans
Function: Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable). Involved in cleaving dsRNA in the RNAi pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa. Involved in innate immunity through its role in small RNA processing.
Interaction partners:
- DRBM domain-containing protein
- Protein argonaute-1
- Protein argonaute-1
- Piwi domain-containing protein
- DRBM domain-containing protein
- Piwi-like protein ergo-1
- Helicase ATP-binding domain-containing protein
- 3'-5' exonuclease eri-1
- RNA-directed RNA polymerase
- DRBM domain-containing protein
Sequence:
MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAACDSDLKDFQQIEKILLSRHRTVNNPIEDDSDRFEEFDVDSQMEPYVVEKTGATLKMSTAIALINRYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNEIERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV
Protein: Insulin growth factor-like family member 2 (Q6UWQ7)
Organism: Homo sapiens (Human)
Function: Potential ligand of the IGFLR1 cell membrane receptor.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MVPRIFAPAYVSVCLLLLCPREVIAPAGSEPWLCQPAPRCGDKIYNPLEQCCYNDAIVSLSETRQCGPPCTFWPCFELCCLDSFGLTNDFVVKLKVQGVNSQCHSSPISSKCESRRRFP
Protein: 5' exonuclease Apollo (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) (A0A3B3ITQ0)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNGVLIPHTPIAVDFWSLRRAGTARLFFLSHMHSDHTVGLSSTWARPLYCSPITAHLLHRHLQVSKQWIQALEVGESHVLPLDEIGQETMTVTLLDANHCPGSVMFLFEGYFGTILYTGLYSLGKESLLEQLALEFQTWVVLSPRRLELVQLLGLADVFTVEEKAGRIHAVDHMEICHSNMLRWNQTHPTIAILPTSRKIHSSHPDIHVIPYSDHSSYSELRAFVAALKPCQVVPIVSRRPCGGFQDSLSPRISVPLIPDSVQQYMSSSSRKPSLLWLLERRLKRPRTQGVVFESPEESADQSQADRDSKKAKKEKLSPWPADLEKQPSHHPLRIKKQLFPDLYSKEWNKAVPFCESQKRVTMLTAPLGFSVHLRSTDEEFISQKTREEIGLGSPLVPMGDDDGGPEATGNQSAWMGHGSPLSHSSKGTPLLATEFRGLALKYLLTPVNFFQAGYSSRRFDQQVEKYHKPC
Protein: Uncharacterized mitochondrial outer membrane protein YPR098C (Q06089)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:16823961}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:16823961}.
Interaction partners:
- TMEM14 protein homolog YJR085C
- PUP1 protein homolog
- Uncharacterized protein YBR126W-A
- Uncharacterized protein YBR230W-A
- Glutaredoxin-like protein YDR286C
- Protein MRG3-like
- Uncharacterized peptide chain release factor-like protein YLR281C
Sequence:
MCLVKTTAHLLFYSFVFGGTTFYSYVASPIAFKVLEKDQFSALQNKIFPYFFQMQAASPVILALTAPIALTTGPLSSLVVASVSGLTNLFWLLPWTHKVKEQRKNIAKKYTGSELEAKDAILRKEFGKSHGLSLLFNLSNVCGMLAYGVCLSGGLLRKIPK
Protein: Histocompatibility 2, M region locus 3 (Q8MHM0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGSSSNCALLHMVVVSLAVTQTGSGSHSLRYFHTAVSRPGRGEPQYISVGYVDDMQFQRCDSIEEIPRMEPRAPWMEKERPEYWKELKLKVKNIAQSARANLRTLLRYYNQSEGGSHILQWMVSCEVGPDMRLLGAHYQAAYDGSDYITLNEDLSSWTAVDMVSQITKSRLESAGTAEYFRAYVEGECLELLHRFLRNGKEILQRADPPKAHVAHHPRPKGDVTLRCWALGFYPADITLTWQKDEEDLTQDMELVETRPSGDGTFQKWAAVVVPSGEEQRYTCYVHHEGLTEPLALKWGRSSQSSVVIMVIVASLVLLGGVITIVVVCKRRGAGER
Protein: RRM domain-containing protein (Q95XX9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MMNRKIINKFFGQFGTVFVDWPVKQKPNSRGKSIAIGSYSYLFLVYSDEQSVIKLMSACHRNSQNDFFVSVPGFRDMIQIRPWFIYNGFYILEKARHNRIIDIHRTVFLGGLPRIVTAEEIAQMFSEFGVVLLVTIDIDQDYGYPKGAARVTFERDSAFNRALEKKFLKFDNIDSSKTMIEIKPYVMEDVGCDECGGLWFNPFLSIYDHLKCAKDDHQKEQKMAEIKNFNMWSSRSPFSLNSGDGHDDLITKMDAGFKKNCNLACTYSNRENEKNETEMGARKFLEMVKSFGLEKEKTVTVNGNEYPIGPDLWDKFLPAPKYDVGTEPVRMNPEAKLQQFLRMKRTNVYSNKSAYCKEAPCRQYYCPSCSNKLHSGPNQHTLLPAGKPERRPRKDKNMYLVNMGK
Protein: Photosystem II reaction center protein H (PSII-H) (Photosystem II 10 kDa phosphoprotein) (P0C420)
Organism: Oryza sativa (Rice)
Function: One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00752}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00752}.
Interaction partners:
Sequence:
MATQTVEDSSRPGPRQTRVGNLLKPLNSEYGKVAPGWGTTPFMGVAMALFAVFLSIILEIYNSSVLLDGILMN
Protein: Transcription factor bHLH143 (Basic helix-loop-helix protein 143) (AtbHLH143) (bHLH 143) (Transcription factor EN 129) (bHLH transcription factor bHLH143) (Q9FY69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH144
- Transcription factor bHLH123
- Transcription factor bHLH113
Sequence:
MPLDTKQQKWLPLGLNPQACVQDKATEYFRPGIPFPELGKVYAAEHQFRYLQPPFQALLSRYDQQSCGKQVSCLNGRSSNGAAPEGALKSSRKRFIVFDQSGEQTRLLQCGFPLRFPSSMDAERGNILGALHPEKGFSKDHAIQEKILQHEDHENGEEDSEMHEDTEEINALLYSDDDDNDDWESDDEVMSTGHSPFTVEQQACNITTEELDETESTVDGPLLKRQKLLDHSYRDSSPSLVGTTKVKGLSDENLPESNISSKQETGSGLSDEQSRKDKIHTALRILESVVPGAKGKEALLLLDEAIDYLKLLKQSLNSSKGLNNHW
Protein: NAC domain-containing protein 19 (ANAC019) (Abscisic-acid-responsive NAC) (ANAC) (Q9C932)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factors that bind specifically to the 5'-CATGTG-3' motif.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:12646039}.
Interaction partners:
- Zinc-finger homeodomain protein 11
- E3 ubiquitin-protein ligase RHA2A
- Chaperone protein ClpD, chloroplastic
- Salicylate/benzoate carboxyl methyltransferase
- Transcription factor MYC2
- Dehydration-responsive element-binding protein 2A
- Isochorismate synthase 1, chloroplastic
- Vegetative storage protein 1
- 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic
- ABSCISIC ACID-INSENSITIVE 5-like protein 7
Sequence:
MGIQETDPLTQLSLPPGFRFYPTDEELMVQYLCRKAAGYDFSLQLIAEIDLYKFDPWVLPNKALFGEKEWYFFSPRDRKYPNGSRPNRVAGSGYWKATGTDKIISTEGQRVGIKKALVFYIGKAPKGTKTNWIMHEYRLIEPSRRNGSTKLDDWVLCRIYKKQSSAQKQVYDNGIANAREFSNNGTSSTTSSSSHFEDVLDSFHQEIDNRNFQFSNPNRISSLRPDLTEQKTGFHGLADTSNFDWASFAGNVEHNNSVPELGMSHVVPNLEYNCGYLKTEEEVESSHGFNNSGELAQKGYGVDSFGYSGQVGGFGFM