wanglab/gogpt-training-data huggingface dataset:
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) (Q9JJ19)
Organism: Rattus norvegicus (Rat)
Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell projection, microvillus {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.
Interaction partners:
- Ezrin
- Radixin
- Moesin
- Cystic fibrosis transmembrane conductance regulator
- Sodium-dependent phosphate transport protein 2A
- Beta-2 adrenergic receptor
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Chloride anion exchanger
- Sodium-dependent phosphate transport protein 2C
Sequence:
MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLKKLGVPIREELLRAQEKSEHTEPPAAADTKKAGDQNEAEKSHLERCELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKAGGDEAKLLVVDKETDEFFKKCRVTPSQEHLDGPLPEPFSNGEIQKENSREALVEPASESPRPALARSASSDTSEELNAQDSPKRHDSTEPSSTSSSSDPILDFNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL
Protein: Cytochrome C oxidase subunit IV (PMID:12467979) (Q4GYG7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFARRSLIATVAAATATKPTSSAAQSNANGTAATQSTLLQQRRYDHDRWYGHALELDSHNYKFTGEPPSWMRVRERTEEETNFAKSVLPHVDFASSYECLLFDADRLNGTLNRKEFGNEVRFRLEKQSNTVARAQQLLKDGRAGGDERVENAMIARIFDEEHVQAEMRYVKCIRANELAEDNRLDILPGGSPNSLREKTRWNVNTELHPADRAEIASRLTAWLPEKYHIVYVDDFQTVAANDSCARDAMLRIVEGVSKEYETEARSSGYERDLREVVQELLDDVDPSRHITSEAIKAATDLTQLEEWSRVVHEYNGDERILDIYSRAAELTRNEEHKKLVEDMRQWKKLSNKI
Protein: Kelch domain-containing protein (Q4GZD6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleoside diphosphate kinase-like domain-containing protein
Sequence:
MMSNTTSSGKGPTTFMWNSVPPSGDMPLHGCCHSLANYKDEQLILFGGGALHIIFNDVYCFDLKTSTWSYKETTNSEIVAPRISHSAVVHEDKMYVYGGQDLYMPTRFADVLVLDLITFTWSLIQQQATPAPDGPGDRRLHTAHIYRNCMYVLMGEPCNISNSFWFLDLTTLEWHPVHSSGWFGKPILPLLGHSAQVEGDYLYVFGGYHADSARRNGSPVYNNSLFSYHFPSNTWREVVPSSGPRPSPRYASAMAVIRGRVFIYGGDVDGEVYFDDFWCIDTNIPSSAASQSSSSSSYTTSLVAAPPAASSRWIDITLSCGRGRPSARSGHASAVAQGCLFVVGGELPGDRDVVYYSNRTYRYPLGYLTRLSLVELSSLWLAKCNPANIWMLDTQIPRHVRQLLVRNLNAQDRESTDDMMPCTRVV
Protein: Urease subunit beta (EC 3.5.1.5) (Urea amidohydrolase subunit beta) (P69996)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01953, ECO:0000269|PubMed:8641799}. Note=Also associates with the outer membrane upon autolysis of neighboring bacteria.
Interaction partners:
- Urease accessory protein UreE
- Urease accessory protein UreF
- Urease accessory protein UreG
- Urease subunit alpha
- Urease accessory protein UreH
- Acid-activated urea channel
- Phosphoglucosamine mutase
- Arginase
- IS605 transposase
- Hydrogenase/urease maturation factor HypB
Sequence:
MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF
Protein: Probable glutamine-binding lipoprotein GlnH (GLNBP) (P96257)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Serine/threonine-protein kinase PknG
- Possible conserved membrane protein
- Imidazoleglycerol-phosphate dehydratase
- Glutamate synthase large chain
Sequence:
MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPTPVGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGSNLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVVKTMSITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIREIAPPPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPYGVGINLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD
Protein: E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2) (X6RFN3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAMAIDPVMDGASEIELVFRPHPTLMEKDDSAQT
Protein: Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2) (Q63424)
Organism: Rattus norvegicus (Rat)
Function: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin. Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (By similarity). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:15056281}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q16348}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q16348}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with the cell membrane in resting macrophages and enriched in phagocytic cups and phagosomes after particle internalization. {ECO:0000250|UniProtKB:Q16348}.
Interaction partners:
- Organic anion transporter 3
- Solute carrier family 22 member 4
- Organic cation/carnitine transporter 2
- Solute carrier family 22 member 6
- Multidrug and toxin extrusion protein 1
Sequence:
MNPFQKNESKETLFSPVSTEEMLPRPPSPPKKSPPKIFGSSYPVSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIALGTGGIKPCVAAFGGDQFEEEHAEARTRYFSVFYLAINAGSLISTFITPMLRGDVKCFGQDCYALAFGVPGLLMVLALVVFAMGSKMYRKPPPEGNIVAQVIKCIWFALCNRFRNRSGDLPKRQHWLDWAAEKYPKHLIADVKALTRVLFLYIPLPMFWALLDQQGSRWTLQANKMNGDLGFFVLQPDQMQVLNPFLVLIFIPLFDLVIYRLISKCRINFSSLRKMAVGMILACLAFAVAALVETKINGMIHPQPASQEIFLQVLNLADGDVKVTVLGSRNNSLLVESVSSFQNTTHYSKLHLEAKSQDLHFHLKYNSLSVHNDHSVEEKNCYQLLIHQDGESISSMLVKDTGIKPANGMAAIRFINTLHKDLNISLDTDAPLSVGKDYGVSAYRTVLRGKYPAVHCETEDKVFSLDLGQLDFGTTYLFVITNITSQGLQAWKAEDIPVNKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFSGLAQWAEFVLFSCLLLVVCLIFSVMAYYYVPLKSEDTREATDKQIPAVQGNMINLETKNTRL
Protein: Geminin (O75496)
Organism: Homo sapiens (Human)
Function: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21543332}. Nucleus {ECO:0000269|PubMed:21543332}. Note=Mainly cytoplasmic but can be relocalized to the nucleus. {ECO:0000269|PubMed:21543332}.
Interaction partners:
- DNA replication factor Cdt1
- Multicilin
- DNA replication licensing factor MCM6
- Speckle-type POZ protein
- Cell division control protein 6 homolog
- Origin recognition complex subunit 6
- Cell division cycle protein 20 homolog
- Cyclin-A2
- Origin recognition complex subunit 4
- Cyclin-dependent kinase 1
Sequence:
MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEETVEDSLVEDSEIGTCAEGTVSSSTDAKPCI
Protein: Myelin basic protein (F8W3W8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Myelin membrane {ECO:0000256|ARBA:ARBA00004392}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004392}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004392}.
Interaction partners:
Sequence:
MATASTSGQNPFGLGRKKKAPGVLDQISRFFGGDKKRKGKRPHHSSTRRRGDVNPVVHFFRSFVSSPRPKSRWRELLGLGESRSRSPPKRWSTIF
Protein: Uridine and thymidine phosphorylase (EC 2.4.2.2) (Pyrimidine-nucleoside phosphorylase) (Q23588)
Organism: Caenorhabditis elegans
Function: Catalyzes the reversible phosphorylytic cleavage of uridine and thymidine to uracil and ribose-phosphate or thymine and deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Required for normal lifespan.
Interaction partners:
- Cytidine deaminase
- Cytidine deaminase
- Dihydropyrimidine dehydrogenase [NADP
- Uracil phosphoribosyltransferase homolog
- Purine nucleoside phosphorylase
- Uridine 5'-monophosphate synthase
- Dihydroorotate dehydrogenase
- Thymidine kinase
- Uridine kinase
- Probable deoxycytidylate deaminase
Sequence:
MNGLVKNGNVEKPNKYFDIKDKRDFLYHFGFGVDTLDIPAVFGDTKFVCTGGSPGRFKLYAEWFAKEANIPCSENLSRSDRFVIYKTGPVCWINHGMGTPSLSIMLVESFKLMHHAGVKNPTFIRLGTSGGVGVPPGTVVVSTEAMNAELGDTYVQIIAGKRIERPTQLDAALREALCEVGKEKSIPVETGKTMCADDFYEGQMRLDGYFCDYEEEDKYAFLRKLNALGVRNIEMESTCFASFTCRAGFQSAIVCVTLLNRMDGDQVQIAKEQYIEYEERPFRLVTAYIRKQTGI
Protein: NLR family member X1 (Q3TL44)
Organism: Mus musculus (Mouse)
Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (By similarity). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (By similarity). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (By similarity). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q86UT6}.
Interaction partners:
- Mitochondrial antiviral-signaling protein
- Elongation factor Tu, mitochondrial
- TNF receptor-associated factor 6
- Autophagy-related protein 16-1
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Antiviral innate immune response receptor RIG-I
- NLR family CARD domain-containing protein 4
Sequence:
MRWGCHLPRTSWGSGLGRTPQLPDEHISFLIQWSWPFKGVHPLRPPRAFIRYHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPSTELATGHQQTQAGLPPLALSQLFDPDSCGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQRYTPLKEVLPLMTAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGPPAAIIVNLLRKYMLPEASILVTTRPSTISRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYGAGGASVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTHTSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTALQRVGKEVVEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRMVSKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPSEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPAGLHTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGLLMDGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKAAREHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVILSEVQRNVHSWDPLRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVEGEVKTLLEQLGGSGH
Protein: Leucine zipper putative tumor suppressor 2 (Protein LAPSER1) (Q91YU6)
Organism: Mus musculus (Mouse)
Function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03026}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:18490357}. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. {ECO:0000255|HAMAP-Rule:MF_03026}.
Interaction partners:
Sequence:
MAIVHTLPVPLEPARETATAPKTPAMGSVSSLISGRPCPGGPAPQRHHGVPGPTFFRQQDGLLPGGYEAQEPLCPAVPPRKAVPGNSFTYVNEDFRTESPPSPSSDVEDPREHQAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPGFLGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLALSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTNSPGGHLPSHGPGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSMDESEATVCQAFGARQRRWPRERGEDCAAQAQQATQRVQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAREQELEACSQELQRYRQEAERLREKAGHLDAEASGLRDPPVPPATTDPFLLAESDEAKVQRAAAGAGGSLRAQVERLRQELQREQRRGDEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAESAPCICLEEITATEI
Protein: Agouti-related protein (P56473)
Organism: Mus musculus (Mouse)
Function: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (By similarity). It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:O00253}. Golgi apparatus lumen {ECO:0000250|UniProtKB:O00253}.
Interaction partners:
- Melanocortin receptor 3
- Melanocortin receptor 4
- Pro-opiomelanocortin
- Pro-neuropeptide Y
- Appetite-regulating hormone
- Leptin
- Forkhead box protein O1
- Insulin-2
- Insulin-1
- Hypocretin neuropeptide precursor
Sequence:
MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQKAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLCSRT
Protein: MKIAA1858 protein (Q80T82)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
RDCHHCGKQFPKPFKLQRHLAVHSPQRVYLCPRCPQVYPEPWELKVHLGLTHGVTEEKELPHVPLYACELCANVMHVIRRSFVCSSCNYTFAKKEQFDRHMGKHLSCDLQPFTLRSVKRPGVPRRKTRVSQDVLPSKQNRLMAPFSPPELSTDRIPSTTSPTPSEVSLPALPLAPSLILDQPSSQENPVDQADHSPRGNNLPLSGQDLPPPSLSPFSAASAEGTGGCCKLNRTLEKPEHEASLGSLEPCKWQALVGEKRALHLFPGKHKSPGNGDKCAPGCSPGHPSQLQERLVTTHHMAPEGRIEGPSQKGNATKPGAYSSTSHHRAAEPTKKALKPPAPPRKPGGMGIPAAELVLSPEDRVKPNTSKGKLRGTPQSSGGLQPGTQTGGGSQPQPTSGQLQSEMASTPTEPSCPSWASSTPDQPPPRAHTKGSTRGPGDTVHQGVQVHSSPREKRESHGKQRKGQALGLGRHGSVGNTGKAPLAPDKSSRAPRKQATPSRVPPVKSRPSGQSSRARPQPSAQRKGDPGHTSEKGSLPQARALSRPYKRVRALHVSGVAPMEPRDRRTAEAQSDLLSQLFGQKLTSFRIPLKKDSSQ
Protein: Hsp90 co-chaperone Cdc37-like 1 (Q9CZP7)
Organism: Mus musculus (Mouse)
Function: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Stress-induced-phosphoprotein 1
- Serine/threonine-protein phosphatase 5
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Secreted phosphoprotein 24
- Endoplasmin
Sequence:
MEQPWPPPGPWSFPRTGGETEEESDLDVSPSSSHYSPVPDGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQRERMCLWNMDAISKDVFNKSFINQDKRKTEEEDKSQSFMQKYEQKIRHFGMLSRWDDSQRFLSDHPHLVCEETAKYLILWCFHLEAEQKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYAQSQSLQPVTVQNHVPHSGVGCIGSLESLPQNPDSLQCCTPAPLCSVDSVVHKEDDDRMMDTV
Protein: Probable G-protein coupled receptor 19 (Q61121)
Organism: Mus musculus (Mouse)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Adropin
Sequence:
MVFAHRMDNDQPPVVTATLLVPLQNSSCAEAAEALLPHGLMGLHEEHSWMSNRTELQYELNPGEVATASIFFGALWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVVLQFTTGRWTLGSAMCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWILDAAFVTPVFFFYGSNWDSHCNYFLPPSWEGTAYTVIHFLVGFVIPSILIILFYQKVIKYIWRIGTDGRTLRRTMNIVPRTKVKTVKMFLLLNLVFLFSWLPFHVAQLWHPHEQDYKKSSLVFTAVTWVSFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKRNYVGISEIPPVSRTITKDSIYDSFDREAREKKLAWPINSNPPNTFV
Protein: Mucin 16 (Q9D1H1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTSGSTVVTLEALFSSHLDPNLVKQVFLNKTLNASSHWLGATYQLKDLHVIDMKTSILLPAEIPTTSSSSQHFNLNFTITNLPYSQDIAQPSTTKYQQTKRSIENALNQLFRNSSIKSYFSDCQVLAFRSVSNNNNHTGVDSLCNFSPLARRVDRVAIYEEFLRMTHNGTQLLNFTLDRKSVFVDGYSQNRDDDVMKNSGLPFWAIILICLAVLLVLITCLMCCFLVTVCRRKKEGDYQVQRHRLAYYLSHLDLRKLQ
Protein: LIM homeobox transcription factor 1-beta.1 (LIM homeobox protein 1b) (Xlmx1b) (Q8UVR3)
Organism: Xenopus laevis (African clawed frog)
Function: Required for early specification of the kidney glomus, lying upstream of wt1 in the pathway controlling glomus differentiation. The balance in levels and expression patterns of binding partners such as lhx1/lim-1 influences differentiation into glomus or tubule derivatives. Involved in specification of serotonergic neurons.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDIATGPESLDRCFTRGPSDCAKMLDTIKMEDHPLRTGTATLGVLLGSECQHQAVCEGCQRPISDRFLMRVNEASWHEECLQCTVCQQPLTTSCYFRDRKLFCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLSCFCCCVCERQLRKGDEFVLKEGQLLCKSDYEKEKDLLSSGSPDDSDSVKSDDEEGDVKPGKGRVNQGKGSDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKIKKLARRHQQQQEQQNSQRLGQEVMSSRMEGMMTSYAPLAPSQQQIVTMDQNSYSTDPFQQGLTPPQMPGDHMNPYGNDTIFHDIDSDTSLTSLSDCFLASSEVTSMQARVGNPIDRLYSMQSSYFAS
Protein: Stripe a protein (Q7JP26)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLLTMRRQNELIVGSQQHPSATSSASSSAGATSSPGLSGQNLNLVAGAGAATNSTSANSQDSLNTPTTPLLGLSRNPLQFAPPPAPPIAVPSPAASGPTFGYYQTANAAPPLHHSPAATSEVSTAPQPPVELDEYVDILQVQQLLLDSSAAAAAAANNPPTTEQSVQQPQQNTVVQPHPHQQQQQPQQQQQQPQQVLAKPRPRINLQKATEYAAQLAQVESSSPGSRRVLLDYPSPYLYGNPYHHHTPPGEDLVALWFGSNGTGGVAPGTPSAAMIMEGLETLVAPTHHAFLLTETAAAAHFNVLSFDTCLFKTSTAAQSSGSPSTATYLSPAQFGGSHHGGASTSSNSLNSSSTASSSSTSSSLLHYTTASAAAAAAAAAAASANNSVLRARNQTATPTQGGSPGHVAVQPSATASSGRSSASHLSLLNTSGQHSPTSSAVEQVEAHKQLIEALPGDLNTPVTTSSDIPSFFGPTTVVEPPPITGSIESEDLSLEPQVISVASPVLSHCSPLKEERSTPPALAIVKEESSNNSCNMYPQHNNNNNNNNNTTSSSTTTTSKQTTSESNTECVGSPGNHTQSHQQQQQQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSSPQQQYQQHQILHQQQQFGYHHHHHHHHHHHHSQLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQQQQHHQQHYQQHAIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKKEKVRGEQQQQQQQQQQQQQQQQQQQLQQQQEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASM
Protein: General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 5.6.2.3) (DNA 5'-3' helicase XPD) (DNA repair helicase RAD3 homolog) (Protein rhp3) (DNA repair helicase rad15) (RNA polymerase II transcription factor B subunit rad15) (TFB subunit rad15) (P26659)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/rad15 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. XPD/rad15 acts by forming a bridge between TFIIK and the core-TFIIH complex. Involved in the maintenance of the fidelity of DNA replication.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH subunit tfb1
- General transcription and DNA repair factor IIH subunit ssl1
- General transcription and DNA repair factor IIH subunit tfb4
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH subunit tfb2
- Cyclin mcs2
- Serine/threonine-protein kinase crk1
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
Sequence:
MKFYIDDLPILFPYPRIYPEQYQYMCDLKHSLDAGGIALLEMPSGTGKTISLLSLIVSYQQHYPEHRKLIYCSRTMSEIDKALAELKRLMAYRTSQLGYEEPFLGLGLTSRKNLCLHPSVRREKNGNVVDARCRSLTAGFVREQRLAGMDVPTCEFHDNLEDLEPHSLISNGVWTLDDITEYGEKTTRCPYFTVRRMLPFCNVIIYSYHYLLDPKIAERVSRELSKDCIVVFDEAHNIDNVCIESLSIDLTESSLRKASKSILSLEQKVNEVKQSDSKKLQDEYQKLVRGLQDANAANDEDQFMANPVLPEDVLKEAVPGNIRRAEHFIAFLKRFVEYLKTRMKVLHVIAETPTSFLQHVKDITFIDKKPLRFCAERLTSLVRALQISLVEDFHSLQQVVAFATLVATYERGFILILEPFETENATVPNPILRFSCLDASIAIKPVFERFRSVIITSGTLSPLDMYPKMLQFNTVMQESYGMSLARNCFLPMVVTRGSDQVAISSKFEARNDPSVVRNYGNILVEFSKITPDGLVAFFPSYLYLESIVSSWQSMGILDEVWKYKLILVETPDPHETTLALETYRAACSNGRGAVLLSVARGKVSEGVDFDHHYGRAVIMFGIPYQYTESRVLKARLEFLRDTYQIREADFLTFDAMRHAAQCLGRVLRGKDDHGIMVLADKRYGRSDKRTKLPKWIQQYITEGATNLSTDMSLALAKKFLRTMAQPFTASDQEGISWWSLDDLLIHQKKALKSAAIEQSKHEDEMDIDVVET