wanglab/gogpt-training-data huggingface dataset:
Protein: Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37) (Q494V2)
Organism: Homo sapiens (Human)
Function: May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8I4E9}.
Interaction partners:
- Transmembrane and coiled-coil domains protein 1
- Podocalyxin-like protein 2
- Krueppel-like factor 15
- Plexin-D1
Sequence:
MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELLFFFT
Protein: Gasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)] (Q9BYG8)
Organism: Homo sapiens (Human)
Function: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.
Subcellular location: [Gasdermin-C]: Cytoplasm, cytosol {ECO:0000269|PubMed:11223543}.; SUBCELLULAR LOCATION: [Gasdermin-C, N-terminal]: Cell membrane {ECO:0000269|PubMed:32929201}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Interaction partners:
- Gasdermin-B
- Gasdermin-E
- Pejvakin
Sequence:
MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDEYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWDVEAKMPLSALYGTLSLLQQLAEA
Protein: Cannabichromenic acid synthase (EC 1.21.99.-) (Q33DQ2)
Organism: Cannabis sativa (Hemp) (Marijuana)
Function: Oxidoreductase involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity. Catalyzes the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA) producing cannabichromenic acid (CBCA), which exhibits anti-inflammatory, antifungal and antimicrobial effects. Can also use cannabinerolic acid (CBNRA) as substrate. Unable to catalyze the production of delta(9)-tetrahydrocannabinolate (THCA), the precursor of Delta(1)-tetrahydrocannabinol.
Interaction partners:
Sequence:
MNCSAFSFWFVCKIIFFFLSFNIQISIANPQENFLKCFSEYIPNNPANPKFIYTQHDQLYMSVLNSTIQNLRFTSDTTPKPLVIVTPSNVSHIQASILCSKKVGLQIRTRSGGHDAEGLSYISQVPFAIVDLRNMHTVKVDIHSQTAWVEAGATLGEVYYWINEMNENFSFPGGYCPTVGVGGHFSGGGYGALMRNYGLAADNIIDAHLVNVDGKVLDRKSMGEDLFWAIRGGGGENFGIIAAWKIKLVVVPSKATIFSVKKNMEIHGLVKLFNKWQNIAYKYDKDLMLTTHFRTRNITDNHGKNKTTVHGYFSSIFLGGVDSLVDLMNKSFPELGIKKTDCKELSWIDTTIFYSGVVNYNTANFKKEILLDRSAGKKTAFSIKLDYVKKLIPETAMVKILEKLYEEEVGVGMYVLYPYGGIMDEISESAIPFPHRAGIMYELWYTATWEKQEDNEKHINWVRSVYNFTTPYVSQNPRLAYLNYRDLDLGKTNPESPNNYTQARIWGEKYFGKNFNRLVKVKTKADPNNFFRNEQSIPPLPPHHH
Protein: Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (AmyHha) (A0A096XJN4)
Organism: Hypothenemus hampei (Coffee berry borer)
Function: Involved in the digestion of starch (Probable).
Interaction partners:
Sequence:
MQHLSILLVVLGSSIAFAQHDPHFADGRNTIVHLFGWKWGDIASECENWLRKKGFAGVQISPPSENPIVSGRPWWENYQPVSYDLKNRNGDEDSLSDMIKRCNNVGVRIYADLVVNHMATSIGQGTADHSYDPGSKSYPAVPYSNENFHASCDIDYNDAASIRNCELSGLKDLDQSQDYVRGKIVDYMNHLVSLGVAGFRVDAAKHMWPADLAAIFGSVNDLNTDFFPSGSRAYIYQEVIDTGSDPIDNKDYTGFGSVCEFKYGIQLATCFRGSNPLKYLENWGTGWGLLDGGNTLVFIDNHDTERSSGSYLNYKESRAYKAANAFMLAHPYDGITKIMSSYDFSDNDQSPPSDGDNILSPGFKEDGTCTNGWICQHRWSPIFNMVEFRSVVSGIELTNWWSGGDYQIAFSRGTKGTIAISINDSLDSDVPTGLPDGTYCDVISGSLSNGSCTGKSITVSGGKAHISIASDDREAAVAIHANAKL
Protein: Homeotic protein antennapedia (P02833)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein extradenticle
- Homeobox protein abdominal-A
- Homeobox protein homothorax
- Protein teashirt
- Homeotic protein Sex combs reduced
- Homeotic protein ultrabithorax
- Heme oxygenase
- Homeobox protein abdominal-B
- Protein decapentaplegic
- Homeotic protein deformed
Sequence:
MTMSTNNCESMTSYFTNSYMGADMHHGHYPGNGVTDLDAQQMHHYSQNANHQGNMPYPRFPPYDRMPYYNGQGMDQQQQHQVYSRPDSPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQPSQNQQQQQAQQAPQQLQQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGMPSPLYPWMRSQFGKCQERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGEPGSGGEGDEITPPNSPQ
Protein: PatA subfamily (P74294)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Activator of photopigment and puc expression
- Circadian input-output histidine kinase CikA
- Circadian input-output histidine kinase CikA
- Circadian input-output histidine kinase CikA
- Circadian input-output histidine kinase CikA
- CheY subfamily
- Circadian input-output histidine kinase CikA
Sequence:
MSNSVLSTSSPGNIQTRQAIPAQLLYSLVNQKASGKLVVQNPFDEFVYWQVYLGDGRIHLANSANGCSERLNYLIGSTLRQKGIELPSRIADDYIFLSGLWKRDVFSFQQTRSILTQASQEALVQVLSLPKTSYRFNQEKELSELFLNLELEKTITPIKHKIRYWWELRSYINSPFQRPLVENWLSLRQNLVKNNLHGQHWLKRFHTCLENLNCLYEIAGHLEISTLELALMLQPMVKTGEIKMLPYQEIQTDDRPLVAYVDHREVQQRMMTYSLEKEGYRALVLDDPFRALTVLLNSPPNLIIINTDLPDMNGYQLCSFCRKSNQLKDVPILLLGKGDNLISGIRIKLCQASGYLSEPFVPEELLDRVAKLLPTNKTNS
Protein: Cullin-like protein, putative (C6KTD3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Suppressor of kinetochore protein 1, putative
- Ubiquitin-like protein nedd8 homologue, putative
- NEDD8-conjugating enzyme UBC12, putative
- E3 ubiquitin-protein ligase RBX1, putative
- MATH and LRR domain-containing protein PFE0570w
- Thioredoxin-like protein, putative
- Leucine-rich repeat protein
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- Polyubiquitin
Sequence:
MDPTAVNNYPVFYVKNKDFLNVDNEHIRCSLKRFEEYIHECFSILPYNKIKIQNEEKISVQHFCDVLVFNQCEQIICAIIEKECNEKTKQFFEEVEIRIKNEEFKNGEEEFLKLFVSIWNNFSLVLIHISDILQSFIAYTKNMCCNFFDPTQIFNYLWKKYINQYVIIKNMFISSICNYLTYDKIYCETYFYEYVCVNICNKYATKRYNLKKNQINYIERLQNIQKNYQVNNEATNKQTNKINKKDCINKKEIPTENITYKTKEEEHIQRGDHNNNNNYNNSYDNNNYSDDIYNSNPYLDDTNHEYKNTQKKKKINDKVLSLSIKISDILNLYDDFERIYKNETYTFYKEKIEKYKKDMETLGYEECNFDFPIIVENYLCHEQIRSRKFLKEHTEITILNMLKDLLLVKNRDVLFKDSYIKYCIIKEKYDPLRSVYLYSLNLDDLENFSNIFFNVVDNIGTELVNDVINKRNNSSLLNNAIIKLINFKLNVDRIIIMSFRYSSYFMKKWREVFEHFINKGIQAETYMPIILSMYLNNLLTMYNACLRKLKKYYILNKKIKNNRSLFNNLLFEVDWNNYCTQPISETIDFYDISTDSDNMLGIKKYLRKKRKNTKKDLINFEHEEEYVKRKHMDNNIHNNDHNDNIYFNNNLYFNNDYHNNLYYDSLNINKRSDEKIFFHLLKIDKLFKKYHIIGKYIMNMITVILSLFRYVSDKEKFEKYYRTYMCKRLINDSSFNIILDVKVFKTLKKECGAQFTKKIEIILKDMKFTSKTLMKFYKELPNNVNHFLKRKKYAVNIIFNESWEYVNTENNVIYPPMIKMCNEAFFLFYQKYNKSKNIKFLPLLGLCTLRVHFKNFKEEGSFDLGKRDDNNDEKRDDNNDEKRDHNNIEKRDDNNIEKRDDNNIEKRDDNNIEKRDDNNDEKRDENNDKKRDENNNYSDDNDDDLNNEDSSSTYNKKGKKKIYITVTILQALVLLLFNKKNEYHINEIKELTGISTENIIRYLKTIYTIGETHILIYDKANEILKLNFSFRSKKKFLIVNYNDVLYKDDMGPTTSLLNEDNEIEDKTLHIDAAIVKFLKTNGKSSERKICSFIKDKMDISSNEQIKNRISSLLSREFIFFKNNNYHYEL
Protein: Calmodulin (Q38D28)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTASARGSGVIKAMAGDVFNTFHIVAPDGDAFIPPCFVMAAAHEMGYYPTAHYLQQVVSVTTGWCGRVTYPLFLQMCAMLEGTRALDDATIKCYRDAFDVRGNGELSRTEFRIILATSAASELTSCEAEAIIDFLDPHGTNIVKLRDLEELLMKCLAVDGEPVDPVVSSKRSSGRSRFMESSRISGQDFPPHSRSSGATDKGRKTVVAESKMSGDSSRARGAPPHATAPRSPSTSAVSEARQPLAEGRKREPSPLPGVLEGLVSSQERTSRGIAPPKTTAPSPCLSGAVTRATSVAHFESPPSQVVSTNPGYSPPPMEDAMESPYAPNAYQQGSAEMPVGALHLDPHSTTAAFSAFPVARESTRGPEGTQEWPPGSSGFTGRTNETHTGWRVLSIPSLEEMRDVTTENSRVVSQRSNARHSGENMPSQDGAACRGSGRSVGTYTGSDMVCASLPNQRRPKSSPCCAMF
Protein: Monolignol oxidoreductase AtBBE-like 15 (EC 1.1.99.-) (Berberine bridge enzyme-like 15) (AtBBE-like 15) (Protein EMBRYO SAC DEVELOPMENT ARREST 28) (Protein MATERNAL EFFECT EMBRYO ARREST 23) (O64743)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for endosperm development and polar nuclei fusion. Mediates oxidation of cinnamyl alcohol and of p-hydroxylated derivatives of cinnamyl alcohol (i.e. the monolignols p-coumaryl-, coniferyl-, and sinapyl alcohol) to their corresponding aldehydes. Can use cinnamyl alcohol and derivatives, as well as beta-O-glycosylated form of coniferyl alcohol (coniferin) as substrate.
Subcellular location: Secreted, cell wall {ECO:0000303|PubMed:26037923}.
Interaction partners:
- Aldehyde dehydrogenase family 2 member C4
- AT1g27100/T7N9_16
- RING-type E3 ubiquitin transferase
- At5g45880
- Allergen, putative
- F28N24.16 protein
- Pollen-specific protein-like At4g18596
- Translation initiation factor eIF2 assembly protein
- LUC7 related protein
- Allergen-like protein BRSn20
Sequence:
MAFAISKRNATLFLVTLLLISVPLSSSTLQQDFVKCLVDNSDVSFPITASFFSPDQNATLFKEELESTAQNLRYLTPSNPKPVFIFEPLYETHVQAAVVCAKKLQLHLRLRSGGHDYEGLSFVAEDETPFVIVDLSKLRQVDVDLDSNSAWAHAGATIGEVYYRIQEKSQTHGFPAGLCSSLGIGGHLVGGAYGSMMRKFGLGADNVLDARIVDANGQILDRAAMGEDVFWAIRGGGGGSFGVILAWKIKLVPVPATVTVFTVTKTLEQDGTKVLYKWEQIADKLDDDLFIRVIISPASKTTKPGNRTISMSYQAQFLGDSNRLLQVMQKSFPELGLTKKDCTEMSWIKSVMYIAGFPNSAAPEALLAGKSLFKNHFKAKSDFVKEPIPVEGLEGLWERFLEEDSPLTIWNPYGGMMSRISESEIPFPHRNGTLFKIQWLSTWQDGKVSEERHMKWIREMYSYMEQYVSKNPRQAYVNYRDLDLGTNEGETDAREWGAKYYKGNFERLVKIKGEFDPDNFFRHEQSVPTKIG
Protein: Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) (Q86WC4)
Organism: Homo sapiens (Human)
Function: Required for osteoclast and melanocyte maturation and function.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:21527911}; Single-pass type I membrane protein {ECO:0000269|PubMed:21527911}. Note=Requires CLCN7 to travel to lysosomes.
Interaction partners:
- H
- V-type proton ATPase 116 kDa subunit a 3
- Pleckstrin homology domain-containing family M member 1
- H
- Carbonic anhydrase 2
- Sorting nexin-10
- Tumor necrosis factor receptor superfamily member 11A
- Tumor necrosis factor ligand superfamily member 11
- H
Sequence:
MEPGPTAAQRRCSLPPWLPLGLLLWSGLALGALPFGSSPHRVFHDLLSEQQLLEVEDLSLSLLQGGGLGPLSLPPDLPDLDPECRELLLDFANSSAELTGCLVRSARPVRLCQTCYPLFQQVVSKMDNISRAAGNTSESQSCARSLLMADRMQIVVILSEFFNTTWQEANCANCLTNNSEELSNSTVYFLNLFNHTLTCFEHNLQGNAHSLLQTKNYSEVCKNCREAYKTLSSLYSEMQKMNELENKAEPGTHLCIDVEDAMNITRKLWSRTFNCSVPCSDTVPVIAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENSN
Protein: Uncharacterized protein YehP (P33352)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YehM
- Uncharacterized protein YehL
- Uncharacterized protein YehI
- Uncharacterized protein YfeS
Sequence:
MSELNDLLTTRELQRWRLILGEAAETTLCGLDDNARQIDHALEWLYGRDPERLQRGERSGGLGGSNLTTPEWINSIHTLFPQQVIERLESDAVLRYGIEDVVTNLDVLERMQPSESLLRAVLHTKHLMNPEVLAAARRIVCQVVEEIMARLAKEVRQAFSGVRDRRRRSFIPLARNFDFKSTLRANLQHWHPQHGKLYIESPRFNSRIKRQSEQWQLVLLVDQSGSMVDSVIHSAVMAACLWQLPGIRTHLVAFDTSVVDLTADVADPVELLMKVQLGGGTNIASAVEYGRQLIEQPAKSVIILVSDFYEGGSSSLLTHQVKKCVQSGIKVLGLAALDSTATPCYDRDTAQALVNVGAQIAAMTPGELASWLAENLQS
Protein: Nuclear transport factor 2B (AtNTF2b) (NTF-2) (Q9C7F5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16428596}. Nucleus {ECO:0000269|PubMed:16428596}. Nucleus envelope {ECO:0000269|PubMed:16428596}. Note=Accumulates at the nuclear rim. Excluded from the nucleolus. {ECO:0000269|PubMed:16428596}.
Interaction partners:
- Ran-binding protein 1 homolog c
- RAN GTPase-activating protein 1
- AT5G65740 protein
- Snurportin-1
Sequence:
MSQMDPDAVSKAFVEHYYSTFDTNRVGLAGLYQEASMLTFEGQKIQGVQSIVAKLTSLPFQQCKHHISTVDCQPSGPASGMLVFVSGNLQLAGEEHALKFSQMFHLMPTPQGSFYVFNDIFRLNYA
Protein: BCL2 interacting protein 3 like b (BCL2/adenovirus E1B interacting protein 3-like) (Bnip3l protein) (Q58EQ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MSDAAAPADNNGEPGLNGSWVELEMNRNAASLSSSIASVPPPLAQVVEEDDGMVGGLEHVPSSSSIHNGDMEKILLDAQHESSRSNSSCDSPPRPHSPQDEGQIIFDVDTRRDSQEEVMEKIRDDDILMKDSDRMADWSSRPENIPPKEFHFRHPRRSVTLSMRKTGAMKKGGIFSAEFLKVFIPSLLLSHILVLGLGVYIGKRLTTPPASSI
Protein: Small ribosomal subunit protein eS28A (40S ribosomal protein S28-A) (S33) (YS27) (Q3E7X9)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS27B
- Small ribosomal subunit protein uS19
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein uS14A
- Small ribosomal subunit protein eS30A
- Small ribosomal subunit protein uS8B
- Small ribosomal subunit protein eS17A
- Small ribosomal subunit protein eS26B
- Small ribosomal subunit protein eS7A
- Small ribosomal subunit protein uS8A
Sequence:
MDNKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILVLMESEREARRLR
Protein: Cyclin-G1 (Cyclin-G) (P51959)
Organism: Homo sapiens (Human)
Function: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10196184}. Note=DNA replication foci after DNA damage.
Interaction partners:
- Cellular tumor antigen p53
- Cyclin-G-associated kinase
- E3 ubiquitin-protein ligase Mdm2
- Cyclin-G2
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Cyclin-dependent kinase 5
- Cyclin-L2
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 2
Sequence:
MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP
Protein: Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Q07120)
Organism: Rattus norvegicus (Rat)
Function: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 promoter region. Implicated in the maintenance of inner ear hair cells (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots. {ECO:0000250}.
Interaction partners:
- Endothelial transcription factor GATA-2
- Lysine-specific histone demethylase
- [histone H3]-lysine
- Erythroid transcription factor
- Histone deacetylase 1
- Ataxin-1
- Runt-related transcription factor 1
- Histone deacetylase 1
- Atonal bHLH transcription factor 1
- POU domain, class 4, transcription factor 3
Sequence:
MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPVPGRADGGAVSAGESKMEPRERLSPESQLTEAPDRASASPNSCEGSVCDPSSEFEDYWRPPSPSVSPASEKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGAESGRPAARYGSEQAAGGAGAGQPGSCGAASGATSAGGLGLYGDFAPAAAGLFERPSTAAGRLYQDRGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK
Protein: T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein) (O43763)
Organism: Homo sapiens (Human)
Function: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Influenza virus NS1A-binding protein
- Ran-binding protein 17
- Sodium/calcium exchanger 1
- Phospholamban
Sequence:
MEPGMLGPHNLPHHEPISFGIDQILSGPETPGGGLGLGRGGQGHGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGPGGVIRVPAHRPLPVPPPAGGAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV
Protein: Protein ARV (Q8SYH1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368065}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368065}.
Interaction partners:
- RING-type E3 ubiquitin transferase
- RING-type E3 ubiquitin transferase
- RING-type E3 ubiquitin transferase
- Pickpocket 5, isoform B
- Stretchin-Mlck, isoform U
Sequence:
MSEKKRFVCVNCGHRVKELFKKYSNTMKTTQCDNCHQITDKYIEFEEFIILIDALLLDSCAFRHIIYNGDFKLYWKVSLVVLLLESFALCRQKLPDPPNASLHVHEKGFYTYTLQNMGDYMFMTLLLLIITATLSIDWMQKIGFRNFSLIILKVVLISNLSKFFLLPILVWRNNTTVFGRNLHHLLVMGHHLCSLVLAYQAVGATRKNLRWWALTLVVIAFAFKETARQFVSLVVEDN
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (A0A1D8PKE2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- High osmolarity signaling protein SHO1
- Mitogen-activated protein kinase HOG1
- MAP kinase kinase kinase
- mitogen-activated protein kinase kinase kinase
- Oxidative stress response two-component system protein SSK1
- Phosphorelay intermediate protein YPD1
- Histidine protein kinase SLN1
- Ste50p
- Cell division control protein 42 homolog
- Mid1p
Sequence:
MVEDKDIDLNINNLKIHDAPTRTPPVSSPPALPTPPTPSGISLNTTMQAKLMAFQQQRSKAAAAAAAAASVSSSSSGTQASSSSISASTSESSVSTIPANINRTVSGKKKPKPNLKLSDLPLSRNNSLHRSNTSASDSSVTTPEADTPTGKISNEPQPQGLFANYSDYVDIKSGQLNFAGKASLHSKGIDFSSGSSFRVSLDEFEYLEELGRGNYGSVSKVLHKPTGVLMAMKEVRLELDENKFTQILMELDILHKCDSPYIVDFYGAFFVEGAVYMCIEYMDGGSLDRIFGNDVGVKDEYELAYITESVILGLKELKDKHNIIHRDVKPTNILVNTQGKVKLCDFGVSGNLVASLAKTNIGCQSYMAPERINTMRPDDATYSVQSDVWSLGLTILELAVGHYPYPAETYDNIFSQLSAIVDGEPPKLYPKVYSKEAQIFVKSCLAKNPDLRPSYAALLNNPWLIKNRGKETNLAQTVKDRVEEIAKLEKNKSVSRSNSMNKSAAAVPPPRNVESVQSLLRNKVKAPALHRGGLQKVNRSFLNNH
Protein: Transcription factor cep-1 (C.elegans p53-like protein 1) (Q20646)
Organism: Caenorhabditis elegans
Function: Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. Regulates germline apoptosis in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro. Plays a role in cell cycle arrest in the germline in response to DNA damage by UV-C light. However, not required for survival in response to DNA damage induced by UV-C light, indicating that it is unlikely to be involved in DNA repair. Required for induction of ced-13 in response to DNA damage. Regulates DNA damage-induced apoptosis by inducing transcription of the programmed cell death activator egl-1. Regulates germline proliferation by activating phg-1. Modulates lifespan.
Subcellular location: Nucleus {ECO:0000269|PubMed:11557844}.
Interaction partners:
- Programmed cell death activator egl-1
- Checkpoint protein
- Cell death protein 3
- Secreted protein
- Apoptotic enhancer 1 protein
- Cell death protein 4
- Apoptosis regulator ced-9
- Cell death abnormality protein 1
- DNA repair protein RAD51 homolog
- Telomere length regulation protein clk-2
Sequence:
MEPDDSQLSDILKDARIPDSQDIGVNLTQNLSFDTVQKMIDGVFTPIFSQGTEDSLEKDILKTPGISTIYNGILGNGEETKKRTPKISDAFEPDLNTSGDVFDSDKSEDGLMNDESYLSNTTLSQVVLDSQKYEYLRVRTEEEQQLVIEKRARERFIRKSMKIAEETALSYENDGSRELSETMTQKVTQMDFTETNVPFDGNDESSNLAVRVQSDMNLNEDCEKWMEIDVLKQKVAKSSDMAFAISSEHEKYLWTKMGCLVPIQVKWKLDKRHFNSNLSLRIRFVKYDKKENVEYAIRNPRSDVMKCRSHTEREQHFPFDSFFYIRNSEHEFSYSAEKGSTFTLIMYPGAVQANFDIIFMCQEKCLDLDDRRKTMCLAVFLDDENGNEILHAYIKQVRIVAYPRRDWKNFCEREDAKQKDFRFPELPAYKKASLESINIKQEVNLENMFNVTNTTAQMEPSTSYSSPSNSNNRKRFLNECDSPNNDYTMMHRTPPVTGYASRLHGCVPPIETEHENCQSPSMKRSRCTNYSFRTLTLSTAEYTKVVEFLAREAKVPRYTWVPTQVVSHILPTEGLERFLTAIKAGHDSVLFNANGIYTMGDMIREFEKHNDIFERIGIDSSKLSKYYEAFLSFYRIQEAMKLPK
Protein: Riparin-1.5 acid (A6MWS9)
Organism: Crinia riparia (Streambank froglet) (Flinders Ranges froglet)
Subcellular location: Secreted {ECO:0000269|PubMed:16470724}.
Interaction partners:
Sequence:
MKIIVFLAVLMLVSAQVCLVSAAEMEHSSDNELSSRDLVKRFFLPPCAHKGTCNH
Protein: Aspartoacylase (EC 3.5.1.15) (Aminoacylase-2) (ACY-2) (P45381)
Organism: Homo sapiens (Human)
Function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9R1T5}. Nucleus {ECO:0000250|UniProtKB:Q9R1T5}.
Interaction partners:
- Aminoacylase-1
- N-acetylaspartate synthetase
- Glutamate carboxypeptidase 2
- Beta-citrylglutamate synthase B
- Argininosuccinate synthase
- Aspartate aminotransferase, cytoplasmic
- Asparagine synthetase
- Isoaspartyl peptidase/L-asparaginase
- N-acetylaspartylglutamate synthase A
- Aspartate aminotransferase, mitochondrial
Sequence:
MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKKCTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCLH