wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) (P62751)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus {ECO:0000250|UniProtKB:P62750}. Note=Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000250|UniProtKB:P62750}.
Interaction partners:
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS8
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL3
- Elongation factor Tu, mitochondrial
- Small ribosomal subunit protein uS13
Sequence:
MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII
Protein: RNA binding motif single stranded interacting protein 1 (E7ETU5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYAHMQTTAVPVEEASGQQQVAVETSNDHSPYTFQPNK
Protein: Baculoviral IAP repeat-containing 2 (A0A8I6ADV9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MENSTVLSNWTKENKEKMKYDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQFYPSCSFVQTLLSGGLQSAAKNTSPAKSRFAHSLPLEQGGIHSSLPSNPLNSRAVEDFSLRMNPCSYAMSTEEARFLSYSMWPLSFLSPAELAKAGFYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPHCPFLENTSETQRFSVSNLSMQTHSARMRTFLYWPSSVLVQPEQLASAGFYYVDHNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTSEEENADPPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDIVSALLNAEDERREEEKERQSEETASGDLSLIRKNRMALFQQLTCVIPILDDLLEASVLTKEEHDIIRQKTQIPLQARELIDTILVKGNAAASVFKNSLKEVDSTLYEHLFVEKTMKYIPTEDVSGKMELALQHCAC
Protein: Protein transport protein SEC23 (A0A0B4K6T4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}.
Interaction partners:
Sequence:
MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSNCRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPVFIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDLTAKQVQDMLGIGRGAAPGPQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLSELQRDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSHHDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFNSSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNTVQWKLCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWADATSNVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQNFSLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLDTASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTDGGAPVLTDDVSLQLFMEHLKKLAVSTTT
Protein: TEA domain family member 4 isoform 1 (TEA domain family member 4, isoform CRA_b) (D3DUQ6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
Protein: Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (P17325)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P05412}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-2
- Protein c-Fos
- Fos-related antigen 1
- Mitogen-activated protein kinase 8
- Protein FosB
- Fos-related antigen 2.
- Mitogen-activated protein kinase 9
- Transcription factor JunD
- Cyclic AMP-dependent transcription factor ATF-3
- Estrogen receptor
Sequence:
MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGNLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGALSSGGGAPSYGATGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Protein: Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) (Q9GL76)
Organism: Sus scrofa (Pig)
Function: Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q15223}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q15223}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9JKF6}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q15223}. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of hair cells. {ECO:0000250|UniProtKB:Q9JKF6}.
Interaction partners:
- Nectin-3
- Afadin
- Nectin cell adhesion molecule 2
- Partitioning defective 3 homolog
- Cell adhesion molecule 3
- Nectin-4
Sequence:
MARMGLAGAAGRWWGLALGLTAFFLPGAHTQVVQVNDSMYGFIGTDVVLHCSFANPLPGVKITQVTWQKATNGSKQNVAIYNPAMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPAGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGKDDKVLVATCTSANGKPPSVVSWETHLKGEAEYQEIRNPNGTVTVISRYRLVPSREDHRQSLACIVNYHMDRFRESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSMAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGQVPTAIIGGVVGSILLVLFVVGGIVVALCRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPEDSDDEKKAGPLGGSSYEEEEEEEGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
Protein: Homeobox protein BarH-like 2 (Q9UMQ3)
Organism: Homo sapiens (Human)
Function: Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHSCTGSPSLRAYPLLSVITRQPTVISHLVPATPGIAQALSCHQVTEAVSAEAPGGEALASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQEQLEPSQGQEELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS
Protein: Semaphorin-5B (Semaphorin-G) (Sema G) (Q60519)
Organism: Mus musculus (Mouse)
Function: May act as positive axonal guidance cues.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Plexin-A1
- Semaphorin-5A
- Plexin-A3
- Neuropilin-1
- Plexin-A2
- Plexin-A4
Sequence:
MVVPGPLALSLLLSSLTLLVSHLSSSQDIASESSSEQQMCTRREHPIVAFEDLKPWVFNFTYPGVRDFSQLALDPSRNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVSGRKVFMCGTNAFSPVCSSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAFDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISKAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRSLRGCYLEELHVLPPGRLEPLRSLRILHSARALFVGLSDRVLRVPLERCSAYHSQGACLGARDPYCGWDGKRQLCSTLEDSSNMSLWIQNITTCPVRNVTRDGGFGPWSPWKPCEHLDGDNSGSCLCRARSCDSPRPRCGGLECLGPSIHIANCSRNGAWTAWSSWAQCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSNNCGGGVQSRRRSCENGNSCPGCGVEFKTCNPEACPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLPDPHGLQFGKRRTETRTCPADGTGACDTDALVEDLLRSGSTSPHTLNGGWATWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTAWSQCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCSTQACPEGWSLWSEWGVCTEDGAQSRSRSCEELLPGPGACVGNSSQSRPCPYSEIPVILPASSVEETTSCGGFNLIHLIVTGVSCFLVSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKPSFRPEASPGQRCFPNS
Protein: Probable serine/threonine-protein kinase HSL1 (EC 2.7.11.1) (P34244)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Bud neck {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein arginine N-methyltransferase HSL7
- Mitosis inhibitor protein kinase SWE1
- APC/C activator protein CDH1
- Cell division control protein 12
- M-phase inducer phosphatase
- Cell division control protein 11
- Cell division control protein 3
- G2/mitotic-specific cyclin-2
- Mitogen-activated protein kinase HOG1
- Serine/threonine-protein kinase GIN4
Sequence:
MTGHVSKTSHVPKGRPSSLAKKAAKRAMAKVNSNPKRASGHLERVVQSVNDATKRLSQPDSTVSVATKSSKRKSRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIKKYDDLPVNKVLRKMRKDNMARGKSNSDLHLLNNVSPSIVTLHSKGEIDESILRSLQILWHGVSRELITAKLLQKPMSEEKLFYSLLLQYKQRHSISLSSSSENKKSATESSVNEPRIEYASKTANNTGLRSENNDVKTLHSLEIHSEDTSTVNQNNAITGVNTEINAPVLAQKSQFSINTLSQPESDKAEAEAVTLPPAIPIFNASSSRIFRNSYTSISSRSRRSLRLSNSRLSLSASTSRETVHDNEMPLPQLPKSPSRYSLSRRAIHASPSTKSIHKSLSRKNIAATVAARRTLQNSASKRSLYSLQSISKRSLNLNDLLVFDDPLPSKKPASENVNKSEPHSLESDSDFEILCDQILFGNALDRILEEEEDNEKERDTQRQRQNDTKSSADTFTISGVSTNKENEGPEYPTKIEKNQFNMSYKPSENMSGLSSFPIFEKENTLSSSYLEEQKPKRAALSDITNSFNKMNKQEGMRIEKKIQREQLQKKNDRPSPLKPIQHQELRVNSLPNDQGKPSLSLDPRRNISQPVNSKVESLLQGLKFKKEPASHWTHERGSLFMSEHVEDEKPVKASDVSIESSYVPLTTVATSSRDPSVLAESSTIQKPMLSLPSSFLNTSMTFKNLSQILADDGDDKHLSVPQNQSRSVAMSHPLRKQSAKISLTPRSNLNANLSVKRNQGSPGSYLSNDLDGISDMTFAMEIPTNTFTAQAIQLMNNDTDNNKINTSPKASSFTKEKVIKSAAYISKEKEPDNSDTNYIPDYTIPNTYDEKAINIFEDAPSDEGSLNTSSSESDSRASVHRKAVSIDTMATTNVLTPATNVRVSLYWNNNSSGIPRETTEEILSKLRLSPENPSNTHMQKRFSSTRGSRDSNALGISQSLQSMFKDLEEDQDGHTSQADILESSMSYSKRRPSEESVNPKQRVTMLFDEEEEESKKVGGGKIKEEHTKLDNKISEESSQLVLPVVEKKENANNTENNYSKIPKPSTIKVTKDTAMESNTQTHTKKPILKSVQNVEVEEAPSSDKKNWFVKLFQNFSSHNNATKASKNHVTNISFDDAHMLTLNEFNKNSIDYQLKNLDHKFGRKVVEYDCKFVKGNFKFKIKITSTPNASTVITVKKRSKHSNTSSNKAFEKFNDDVERVIRNAGRS
Protein: At5g43050 (YCF20-like protein (DUF565)) (Q9FMH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Defensin-like protein 130
- At3g56830
- Ycf20-like protein
- Protein disulfide-isomerase LQY1, chloroplastic
- Photosystem II 22 kDa protein, chloroplastic
- Violaxanthin de-epoxidase, chloroplastic
Sequence:
MAHSLSFISTNLNSLVLNHHQCQSFGTFVSSPFKRKRRFARSIRALQETEGPTPRRLIDIIRSVPEISRNYFKKPSRRTLFGGISLLGGFYVAQTISLSFGALGVNDVIAAVLCVLLTEYVTRFYYSRTTVTFPIALLNNFKMGFTYGLFIDAFKLAS
Protein: Pantetheine hydrolase VNN2 (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) (Vascular non-inflammatory molecule 2) (Vanin-2) (O95498)
Organism: Homo sapiens (Human)
Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Pantetheinase
- Pantothenate kinase 1
- Pantothenate kinase 3
- Pantothenate kinase 2, mitochondrial
Sequence:
MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML
Protein: MFP1 attachment factor 1 (Q9M7N6)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Subcellular location: Nucleus envelope. Cytoplasm. Golgi apparatus. Nucleus. Nucleus matrix. Note=Associated with the immature cell plate during cytokinesis. Accumulate in speckles of the cytoplasm belonging to the Golgi apparatus.
Interaction partners:
- MAR-binding filament-like protein 1
Sequence:
MAEIDSAQSQETVTQETQNKPMTTSFSIWPPTQRTRDAVINRLIESLSTPSILSKRYGTLPQDEASETARLIEEEAFAAAGSTASDADDGIEILQVYSKEISKRMIDTVKSRSAPAAASEGESKPSELPADASEPSSASGLTGEVSSVETEP
Protein: Calcipressin-like protein (Down syndrome candidate region 1-like protein) (Regulator of calcineurin) (P53806)
Organism: Caenorhabditis elegans
Function: Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit
- Protein phosphatase 2B regulatory subunit cnb-1
Sequence:
MVADNSEKSTKSVANGSLISTVSSKDDLPNAIIVTQVPEDVFDNKQDKANFSSLFTQIEKDIHFDFLRSFRRVRVIFSSPENATAAKLIVQGFSFKGHELKAFFAQRIYMSANSQMLSPPPLEKQFLISPPCSPPVGWEQTKDMPPVVCNFDLMARLASFAIDEKYEVHNGDELTPAIIVHPCETPIDVPSAIEMPRTPRPSSPCEQ
Protein: Flagellar hook-length control protein (P52614)
Organism: Escherichia coli (strain K12)
Function: Controls the length of the flagellar hook.
Interaction partners:
- Flagellar motor switch protein FliM
- Basal-body rod modification protein FlgD
- Flagellar motor switch protein FliN
- Flagellar FliJ protein
- Flagellar motor switch protein FliG
- Flagellar M-ring protein
- Flagellar hook-basal body complex protein FliE
- Flagellar assembly protein FliH
- Flagellum-specific ATP synthase
- Flagellar protein FliL
Sequence:
MIRLAPLITADVDTTTLPGGKASDAAQDFLALLSEALAGETTTDKAAPQLLVATDKPTTKGEPLISDIVSDAQQANLLIPVDETPPVINDEQSTSTPLTTAQTMALAAVADKNTTKDEKADDLNEDVTASLSALFAMLPGFDNTPKVTDAPSTVLPTEKPTLFTKLTSEQLTTAQPDDAPGTPAQPLTPLVAEAQSKAEVISTPSPVTAAASPLITPHQTQPLPTVAAPVLSAPLGSHEWQQSLSQHISLFTRQGQQSAELRLHPQDLGEVQISLKVDDNQAQIQMVSPHQHVRAALEAALPVLRTQLAESGIQLGQSNISGESFSGQQQAASQQQQSQRTANHEPLAGEDDDTLPVPVSLQGRVTGNSGVDIFA
Protein: Counting factor 45-1 (Q86HE5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cell-counting factor that limits the maximum size of the multicellular structure during aggregation.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Counting factor 60
- Small aggregate formation protein
Sequence:
MNKLISLLLVCLVAIALVNADCAIDFDSDTVNSVTSSDWSCLAASNDRVIMQVFSGGYGYTSGIASAVQGAQAAGISTIDLYAFLCNQCSGNSPSSSAIQSIVSQLQNDGVSYNMLWIDVEQCDGCWGDLGDNAAFVQEAVETAQNLGVNVGVYSSIGEWSQTVGNLSGLGVDLWYAHYDNNPSFSDSSFYEFGGWTSPTMKQYAGNGNECGVSVDMNFFGSGTCSASTGSGSGSSSGSSSGSSSGSSSGSGSSSGSGSSSGSSSGSGSGSSSSGSGSGSGSSSGSGSSSGSGSGSS
Protein: Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (Q9Z2Z3)
Organism: Cricetulus longicaudatus (Long-tailed dwarf hamster)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:O75381}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q642G4}.
Interaction partners:
Sequence:
MASSEQAEQPSQPSSSPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDDEIDLAFQQSGTATEEPPSLGLATPVAPVQTPHLIAQPCSPGSSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMASSLSELSGSVAQTVTQVQTTLASVQELLRQQQQKVQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKESHSPEGSTATYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEEEEEEEEEDVSHVDEEDVLGVQREDRRGGDGQINEQVDKLRRPEGASNESERH
Protein: Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) (Q8N0X7)
Organism: Homo sapiens (Human)
Function: May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19580544}. Midbody {ECO:0000269|PubMed:20719964}. Lipid droplet {ECO:0000269|PubMed:37443287, ECO:0000269|PubMed:38190532}. Note=Transiently associated with endosomes (PubMed:19580544). Colocalized with IST1 to the ends of Flemming bodies during cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:19580544, ECO:0000269|PubMed:20719964}.
Interaction partners:
- HLA class I histocompatibility antigen, C alpha chain
- IST1 homolog
- Sorbin and SH3 domain-containing protein 1
- Epidermal growth factor receptor substrate 15
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- Magnesium transporter NIPA1
- SH3 and cysteine-rich domain-containing protein
- Patatin-like phospholipase domain-containing protein 6
- E3 ubiquitin-protein ligase TRIM45
- Maspardin
Sequence:
MEQEPQNGEPAEIKIIREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISISSKESEHTGPGWESARQMQQKMKETLQNVRTRLEILEKGLATSLQNDLQEVPKLYPEFPPKDMCEKLPEPQSFSSAPQHAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTVSYGTDSGEFSSVGEEFYRNHSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTMLQAAGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVKQLDQGNKDVRHKGKRGKRAKDTSSEEVNLSHIVPCEPVPEEKPKELPEWSEKVAHNILSGASWVSWGLVKGAEITGKAIQKGASKLRERIQPEEKPVEVSPAVTKGLYIAKQATGGAAKVSQFLVDGVCTVANCVGKELAPHVKKHGSKLVPESLKKDKDGKSPLDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTVRYKYGYNAGEATHHAVDSAVNVGVTAYNINNIGIKAMVKKTATQTGHTLLEDYQIVDNSQRENQEGAANVNVRGEKDEQTKEVKEAKKKDK
Protein: Geopilin domain 1 protein (Q74D23)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Geopilin domain 2 protein
- Type IV pilus inner membrane protein PilC
- Twitching motility pilus retraction protein
- Type IV pilus biogenesis ATPase PilM
- Twitching motility pilus retraction protein
- Prepilin leader peptidase/N-methyltransferase
- Type IV pilus assembly protein PilY1
- Type IV pilus assembly protein PilY1
- Type IV pilus minor pilin PilW
Sequence:
MANYPHTPTQAAKRRKETLMLQKLRNRKGFTLIELLIVVAIIGILAAIAIPQFSAYRVKAYNSAASSDLRNLKTALESAFADDQTYPPES
Protein: Taste receptor type 2 member 40 (T2R40) (G-protein coupled receptor 60) (Taste receptor type 2 member 58) (T2R58) (P59535)
Organism: Homo sapiens (Human)
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Taste receptor type 1 member 2
Sequence:
MATVNTDATDKDISKFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDRIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNSVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRDVFNVYVNSSIPIPSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSTSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL
Protein: Glutaryl-CoA dehydrogenase, mitochondrial (EC 1.3.8.6) (K7EKT3)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MALRGVSVRLLSRGPGLHVLRTWVSSAAQTASRPEFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTASK
Protein: Diuretic hormone class 2 (Diuretic peptide) (DH(31)) (DP) (Q9VLK4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Diuretic hormone 44, isoform A
- Leucokinin
Sequence:
MTNRCACFALAFLLFCLLAISSIEAAPMPSQSNGGYGGAGYNELEEVPDDLLMELMTRFGRTIIRARNDLENSKRTVDFGLARGYSGTQEAKHRMGLAAANFAGGPGRRRRSETDV
Protein: Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) (Q9ZUG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03119}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03119}.
Interaction partners:
- Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1
- Methylthioribose kinase
- 3-methyl-2-oxobutanoate hydroxymethyltransferase 1, mitochondrial
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- 5'-methylthioadenosine nucleosidase
- Nicotianamine synthase 1
- Acireductone dioxygenase 2-requiring) 2)
- 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial
Sequence:
MSGEGDTTLKAICYKPGSLQLLDQRKLPLETIYLEIRDASDGWSAIQEMVVRGAPAIAIAAALSLAVEVFNFHGFDGSASDAVAFLENKLDYLVSSRPTAVNLADAALKLKHVIAKALATATEAKSIFKAYIEASEDMLEDDVVSNKAIGNFGLSLLRQQAKNPDKLSVLTHCNTGSLATAGYGTALGVIRALHTQGILERAYCTETRPFNQGSRLTAFELVHEKIPATLIADSAAAALMKDGRVDGVIVGADRVASNGDTANKIGTYSLALCAKHHGIPFYVAAPLTSVDLSLSSGKEIVIEERSPKELMHTHGGLGERIAAPGISVWNPAFDMTPAELIAGIITEKGVITKNGNDTFDISSFAKKITGNSSR