wanglab/gogpt-training-data huggingface dataset:
Protein: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase Cphy0577 (EC 2.4.1.211) (D-galactosyl-1,4-L-rhamnose phosphorylase) (A9KIW5)
Organism: Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Function: Reversibly phosphorolyzes beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine to form alpha-D-galactopyranose 1-phosphate and acetyl-D-glucosamine. Active towards galacto-N-biose and lacto-N-biose. Does not phosphorolyze galacto-N-tetraose or lacto-N-tetraose. In the reverse reaction has activity toward N-acetyl-D-glucosamine and N-acetyl-D-galactosamine, but not L-rhamnose, D-glucose or D-galactose.
Interaction partners:
- Binding-protein-dependent transport systems inner membrane component
- Binding-protein-dependent transport systems inner membrane component
- Extracellular solute-binding protein family 1
- Extracellular solute-binding protein family 1
- Transcriptional regulator, AraC family
Sequence:
MKKDTMLAGRVTIPTDVDVVPETMELLNRWGADAIRDCDGTDYPEELKAVQAKVYSTYYTTRKDNAWAKAHPEEVQQCYIMTSFYTATETTLRIPLLKGIAKELMMVNNYDDKVRWWEVIDRSTAMVVSTDTWSYDKETGEVIITNCEPFHNYTVSFLAYLIWDPVHMYNAVVNGWQGVEHQITFDVRQPKTREYSMVRLRKFIEEHPYVDVIRYTTFFHQFTLVFDEMMREKYVDWYGYSASVSPYILEQFEKEVGYRFRPEFIIDQGYYNNQYRIPSKEFKDFQAFQRREVAKLAKEMVDITHEYGKEAMMFLGDHWIGTEPFMEEFKTIGLDAVVGSVGNGSTLRLISDIPGVKYTEGRFLPYFFPDTFHEGGDPVKEAKVNWVTARRAILRKPIDRIGYGGYLKLACQFPEFIDYVESVCNEFRELYENIKGTTPFCIKRVAVLNSWGKMRAWGAHMVHHALYQKQNYSYAGVIESLSGTPFEVSFISFDDIKKDKNILKNIDVIINVGDGDTAHTGGLVWEDADISSAIHQFVYEGGGLIGIGEPTGHQYQGRYIQLANVFGIEKETGFTLNYDKYNWDAVESHFITEDCTKEVDFGEGKKNMYALEGTTILVQMEKEVQMAVNEFGKGRSVYLSGLPYSFENSRVLYRSILWSAHEEENLHKWYSSNFNVEVHAYVKNNKYCVVNNTYEPQNTTIYRGDSSSFDLELEANEIIWYEI
Protein: RINT1-like protein (DmRINT-1) (Q9VS46)
Organism: Drosophila melanogaster (Fruit fly)
Function: During cytokinesis in male meiotic cells, required for completion of cleavage furrow ingression possibly in conjunction with Zw10. Required for maintenance of Golgi stack number and morphology. Essential for acroblast assembly.
Interaction partners:
- Centromere/kinetochore protein zw10
- Syntaxin-18
- Vesicle transport protein USE1
- Secretory 22, isoform B
- GH11193p
- Conserved oligomeric Golgi complex subunit 3
- Protein zwilch
- LD24550p
- non-specific serine/threonine protein kinase
- Chromosomal serine/threonine-protein kinase JIL-1
Sequence:
MHAELSEMELRIVARLNEEIGKDASQLHRASHLVSHYKKHLQVLSQTLDYEDPQNVSCYKTAFQCQQQVCESIDFELEKLAHFEDKLKRKLKECQPVLEGVAEDLDKVRQLQRLQQYLLLVQDIQEISAALGNAINGKDEDKLVNIYLTLYEGNDCEHSVVGRLHAVQAQSLKSFAERTAIYWHKLLLKRLSSAFEAVLKSMRWAHLEQQALNYSSARDTAKAQLLAEYMFLIKSPAEERAPLQSITPSIVCQPINRVVQLLLAPYRQRFQFHFTGTRQTNRLDKPEWFYTQILNWGKETHFFVGKTFQPAAIKAGKLDYNLRLEFIRGLVQLAIEKLAVDIEQIAQDQILFAHLLDETLAFESELRETFGYPASFPSAISVITQPMYLLRWISLEERFCAEKMDDILQAETPFQLIDPNSFENDLKIPKCADQFMRLLDAIKDRYYGLIQPGHQLQFLHLQLELIDSFRQRLVQLHSSGAVPSIPILNAINYLVMVLREWGENVHYLHLHAALAGPNATEINSVFEHAVAELEHWARQLMRNLATKATNEMKAKSMSYRRDAWPTMPEQNSREPFILSPSGGEMFQVLVTLLHNLERELSANLFTQTLRLIAHQIDDFMLESMVMNTKFSAAGAAQFNYDMTRNLFALFGQYTRRPELLFKRTHDACKLLAAARGTALLLLETLRGNQSVEEKTKPLRELHVLSMDSKQCIEVLERRMDIKMF
Protein: Calpain-5 (EC 3.4.22.-) (Q8R4C0)
Organism: Rattus norvegicus (Rat)
Function: Calcium-regulated non-lysosomal thiol-protease.
Interaction partners:
- Calpain small subunit 1
Sequence:
MFSCTKAYEYQNYSALKRACLRRKVLFEDPHFPASDDSLYYKGTPGPTVRWKRPFDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVVVDDRLPTVNNQLIYCHSNSKNEFWCAPVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRSQLFERVLKVHSRGGLISASIKAMTAADMETRLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGERVWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTYEDMCRYFTDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPQQNRSGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGELLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVTQVHVLGAAGLKDSSTGANSYVIIKCEGEKVRSAVQRGTSTPEYNVKGIFYRKKLSQPITVQVWNNRVLKDEFLGQVHLKTAPDDLQDLHSLHLQDRSGRQPSDLPGIVAVRVLCSASLTAV
Protein: 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74) (P32166)
Organism: Escherichia coli (strain K12)
Function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2), the attachment of the isoprenoid side chain, and a quinol-to-quinone oxidation, which is thought to be spontaneous.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:15919996}.
Interaction partners:
- 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
- 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- 1,4-dihydroxy-2-naphthoyl-CoA synthase
- Octaprenyl diphosphate synthase
- o-succinylbenzoate synthase
Sequence:
MTEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIGPLRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHTLADFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLVFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCLALFNLFSLHSLWGWLFLLAAPLLVKQARYVMREMDPVAMRPMLERTVKGALLTNLLFVLGIFLSQWAA
Protein: C4b-binding protein (C4bp) (P08607)
Organism: Mus musculus (Mouse)
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.
Subcellular location: Secreted.
Interaction partners:
- Complement C4-B
- Zona pellucida sperm-binding protein 3 receptor
- C-reactive protein
- Mannose-binding protein C
- Plasma protease C1 inhibitor
- Mannose-binding protein A
- Plasminogen
- Properdin
- Haptoglobin
- Complement C1s-1 subcomponent
Sequence:
MCAKQQQTLLPTRAAHGRLHRNRDAVAWPFSTLCRVSGPTLFQMTFTAALWVAVFGKCGPPPAIPNALPASDVNRTDFESHTTLKYECLPGYGRGISRMMVYCKPSGEWEISVSCAKKHCRNPGYLDNGYVNGETITFGSQIEFSCQEGFILVGSSTSSCEVRGKGVAWSNPFPECVIVKCGPPPDISNGKHSGTEDFYPYNHGISYTCDPGFRLVGSPFIGCTVVNKTVPVWSSSPPTCEKIICSQPNILHGVIVSGYKATYTHRDSVRLACLNGTVLRGRHVIECQGNGNWSSLPTCEFDCDLPPAIVNGYYTSMVYSKITLVTYECDKGYRLVGKAIISCSFSKWKGTAPQCKALCQKPEVGNGTLSDEKDQYVESENVTIQCDSGFAMLGSQSISCSESGTWYPEVPRCEQEASEDLKPALTGNKTMQYVPNSHDVKMALEIYKLTLEVELLQLQIQKEKHTEAH
Protein: CBY1-interacting BAR domain-containing protein 2 (Protein FAM92B) (Q3V2J0)
Organism: Mus musculus (Mouse)
Function: May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616}. Note=Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). {ECO:0000269|PubMed:27528616}.
Interaction partners:
Sequence:
MNVVLSRDSQVRAMENTVTNAERYFGQFCSLLASYTRKTARLRDKADQLVKQLIDFANTENPELRATIRDFAEDLAKVQDYRQAEVERLEAKVISPLKLYGAQIKQTRADIKKCKRVQNNEIKQLEKLEKLRQKSPSDRQMISQAETSAQRASVDTNRSTLHLVETVDAFQEQKLKDLRRIFSDFVTIEMVFHAKAVEVYSSAFQTLENYDLERDLQDFRAKTRGIYGHGEARPLTDTNPAPSVPWPLASQSAQSTMARQGKEAGGEEDSETDSVEEIPLEDLKGQQQGPRD
Protein: Tubulin tyrosine ligase-like 4A, isoform D (Tubulin tyrosine ligase-like 4A, isoform G) (Tubulin tyrosine ligase-like 4A, isoform H) (Q8IPB2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRNNSGYHIPASNSLNNNGAPASRYCNADNTFCYYSYDNCNLIAPAWGNRQNQNQNSVPNQNHNLPTKRIPTKQSARSSYHQSAANSAPDSSLFTDAFGQQSLVNQRIAGNKSCEYVYQTVQRSEDQHSNRQYKQARSYAVDKEQQQQMLLQPSIVYFDAELKKRKDRGGRVSNDYVDNSPDRYRPLNSPSPEPTWDNILSERPVQYQTTNQHYQHYFSYFYNRGAEKLSKPTFAAANSRKVPMSKFQKAGASRRDSREVDGTVIIGRRDNSEDRTWQGQKYEKHVLKEKLPSNDLKADYLDNGWGGDPGSEDDYRDIKDSYDPVVVIDNGLEQVGVHRRYCRMTENTVLDGSGDTLINNNNNELKIMRKSTDQPMPRLPMTPKRAKGGTVSTKKPMPTVHRVLLYSTQSPRLGRKQQFSTQRLSVKQQSSKVLGAGDERQTVLLLEPEHKQEDHRSAIDFDRNDDFDEDDDLDNLSNFDESDTASVLSDTEDGYRAHAFKLTHSVDRFSSPQSTPSFLSSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSSNTKRGPRVPPDLHRVLKWRITNIMPKVVRLILANSGMRMLKKTNDWMGVWGKHLKSPCFKAIRSYQKINHLPGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPASARGAGIRVINRWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDTLNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTILAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQGVLNTALYNVPPKLSLDKQKELAAEFSFPPGTQMCYDKRLYINYLSREEKIKHNTFTRKSMEDRNEYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHKYLKYNDTPRYYNRLLDAWESRYANNRTEGIALLRDYCQNKYHLQVPTPPAKKDSNDEETTPATPNTVKEEIES
Protein: Solute carrier family 4 member 11 (D3ZVP9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Cytosolic carboxypeptidase 4
- Collagen type VIII alpha 2 chain
- Lipoxygenase homology PLAT domains 1
Sequence:
MSQNEHCQDSGEYFSAATLGYFKNDTDDNPDVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDIEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFAQDPNHAEPDCDLDLLMAKLFTDAGGPMESKVHLLSDTIQGVTATVRGLQYEQSWLCIVCTMKSLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPRPPKCKDFFPFGKGIWVDIMRRFPVYPLDFTDGIIGKGKTVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFWKYYYGHHYHTKRTSSLASLLGISRSPNTSLHTALNTSFLASPIEMTTASSPISTHSNQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLISSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAISSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVNVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8YFD8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPADGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Protein: Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) (Q91XL9)
Organism: Mus musculus (Mouse)
Function: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.
Subcellular location: Late endosome {ECO:0000250|UniProtKB:Q9BXW6}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes. {ECO:0000250|UniProtKB:Q9BXW6}.
Interaction partners:
- Ras-related protein Rab-7a
- Rab-interacting lysosomal protein
- Vesicle-associated membrane protein-associated protein A
- Motile sperm domain-containing protein 2
- Vesicle-associated membrane protein-associated protein B
- Dynactin subunit 1
- StAR-related lipid transfer protein 3
- Protrudin
Sequence:
MNTEAEQQLLHHARNGNAEEVRKLLAAMARMEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVEDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVLLLLEYDADSTVVNGSGQTAKEATHDKEIRNMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAQGAEMKHILVGNKVVHKALKRYEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDSCLFSIRCFDDTVHCFRVPKNSVQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVVSAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADIVSEASRETCVALNDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEEEFYDALSGSESEGSLTCLEAVTAHSFEENEVPGSSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQTSSSEESDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMESVIPKTDCRLRPDIRAMENGEIDLASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY
Protein: Alpha-galactosidase (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Q9FXT4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes melibiose, raffinose and stachyose in the following decreasing order of reactivity: raffinose, melibiose, stachyose. Acts on both the terminal alpha-galactosyl residue and the side-chain alpha-galactosyl residue of the galactomanno-oligosaccharides.
Interaction partners:
- Os01g0952600 protein
- Os11g0672450 protein
- Beta-hexosaminidase.
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-glucosidase-like SFR2, chloroplastic
- Os09g0108600 protein
- Aldose 1-epimerase
- Aldose 1-epimerase
- Galactinol--sucrose galactosyltransferase
Sequence:
MARASSSSSPPSPRLLLLLLVAVAATLLPEAAALGNFTAESRGARWRSRRARRRAFENGLGRTPQMGWNSWNHFYCGINEQIIRETADALVNTGLAKLGYQYVNIDDCWAEYSRDSQGNFVPNRQTFPSGIKALADYVHAKGLKLGIYSDAGSQTCSNKMPGSLDHEEQDVKTFASWGVDYLKYDNCNDAGRSVMERYTRMSNAMKTYGKNIFFSLCEWGKENPATWAGRMGNSWRTTGDIADNWGSMTSRADENDQWAAYAGPGGWNDPDMLEVGNGGMSEAEYRSHFSIWALAKAPLLIGCDVRSMSQQTKNILSNSEVIAVNQDSLGVQGKKVQSDNGLEVWAGPLSNNRKAVVLWNRQSYQATITAHWSNIGLAGSVAVTARDLWAHSSFAAQGQISASVAPHDCKMYVLTPN
Protein: Probable ferric reductase transmembrane component 8 (EC 1.16.1.7) (Ferric-chelate reductase 8) (Q12209)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates (By similarity). Involved in iron homeostasis.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Ferric reductase transmembrane component 6
- Ferric/cupric reductase transmembrane component 7
- Ferric/cupric reductase transmembrane component 1
- Ferric/cupric reductase transmembrane component 2
- Ferric reductase transmembrane component 3
- Ferric reductase transmembrane component 5
- Ferric reductase transmembrane component 4
- Iron-regulated transcriptional activator AFT1
Sequence:
MNLKSIVSWFKEHLPSFDVDVDKHFRTLRVRKYSQICLLISFIIICVIIPLMNYLLLTDKFFKICHHLKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMGRISVALMPPLLFLTLRPSPLPHTLYLALLPLHKWISRIVVLESILHTWFYLYYMYINDTLYVKMRKLPNIYGVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPGISYYTTLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLEFPLTDLPKKPILPGGHLRINIYHRNFLRRFFSHLIPFQHPFTIASIPSDNLVRLIIRNGHFPLRTNEKYYITGAFEPELSFISKPTVPFNITTKSSKNPFRNNSSALINSPLNFLIKAQRVFMCVGGSGISFGLPLLRILNFNGVNVRLLWVSRDYKDLEVLNHFKNNFEGMEIYISGTEGNEQDIEIDYIDYHDCAADINDEVRSISSSGRVSELGDNSMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDINADDEIDFTYAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKIRIPAGVKVFFGRPTLGDKDYEWCLQTECDAETDSIQCCRWANQGRDHAEYLSQVWVLAAGPRGLIESTKRWATDGGLHFHGESFAL
Protein: Heat shock protein 67B3 (Heat shock 18 kDa protein) (P22979)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heat shock protein 23
- Heat shock protein 26
- Heat shock protein 68
- Heat shock protein 67B1
- Heat shock 70 kDa protein cognate 2
- Major heat shock 70 kDa protein Ba
- Starvin, isoform E
- Major heat shock 70 kDa protein Bbb
- Major heat shock 70 kDa protein Aa
Sequence:
MPDIPFVLNLDSPDSMYYGHDMFPNRMYRRLHSRQHHDLDLHTLGLIARMGAHAHHLVANKRNGELAALSRGGASNKQGNFEVHLDVGLFQPGELTVKLVNECIVVEGKHEEREDDHGHVSRHFVRRYPLPKEFDSDAIVSTLSEDGVLNITVPPLVSKEELKERIIPIKHVGPSDLFQNGNGHKEAGPAASASEPEAK
Protein: Glutamine-rich protein (Mediator of RNA polymerase II transcription subunit-like protein) (Q9LF51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM7
- Minichromosome maintenance 10
- Serine/threonine-protein kinase ATR
- DNA replication licensing factor MCM6
- Probable DNA helicase MCM8
- Probable inactive protein kinase At3g63330
- Origin of replication complex subunit 5
Sequence:
MEDTKPPLGGNNNPQQQQQQQQLLYQHQLQQQQRQQQMLLLQQLQKQQQQQAAMSRFPSNIDVHLRPPGLIQNRPINPPPQQNPTPNPNLGQQTPNFQQQQQQNVSSQQMMQQQQQQQQQQKLMRPLNHIELQCAYQDAWRVCHPNFKQPFSSLEDACERLLPYHVVADYEAEEDDRILDSDPTGQALSRSQQWDNNIAAKVAEFTATFEKQALAFNIITRKRAMGEFRSEERLMVEQALLQDERKALIELKAEMDREKAGREAQEAKLRMAALAQAGQSQSHAEIMARNPLRANAVGNQGSNIQLSHEMGEQGRNMNPDEMMNGWGNNSQREDKEPSEDFLNDEENENGETGEQENWREAGEFDLNSR
Protein: Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) (Q8IV36)
Organism: Homo sapiens (Human)
Function: May play an important role in the development of cancers in a broad range of tissues.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21337012}. Golgi apparatus membrane {ECO:0000269|PubMed:21337012}; Lipid-anchor {ECO:0000269|PubMed:21337012}. Note=Shuttles between the cytosol and the Golgi apparatus.
Interaction partners:
Sequence:
MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSASPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILFFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSAAQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRRRRTPEPLSRTGSQEGTSMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPEPQQSLEDGSPAKGEPSQAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTDVKLFEIQRV
Protein: Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A) (Q99MA9)
Organism: Mus musculus (Mouse)
Function: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Required for the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition. Involved in transcriptional regulation of the insulin gene. Together with NKX2-2 and IRX3, restricts the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
Subcellular location: Nucleus {ECO:0000269|PubMed:11076772}.
Interaction partners:
- Neurogenin-3
- Neurogenic differentiation factor 1
- Transcription factor MafB
- Insulin gene enhancer protein ISL-1
- DNA-binding protein RFX6
- Pancreas transcription factor 1 subunit alpha
- Pro-glucagon
- Solute carrier family 2, facilitated glucose transporter member 2
- Transducin-like enhancer protein 3
- Somatostatin
Sequence:
MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGTSENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLLLHASEAEGSS
Protein: Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) (P53675)
Organism: Homo sapiens (Human)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
Interaction partners:
- Clathrin light chain A
- Clathrin light chain B
- Cyclin-G-associated kinase
- Auxilin
- AP-2 complex subunit beta
- Epsin-2
- Epsin-3
- AP-2 complex subunit alpha-1
- AP-2 complex subunit sigma
- Clathrin interactor 1
Sequence:
MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPAPLVFDFDGHE
Protein: Uncharacterized protein (Q584P7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIRRLGSVSSTSSSSLCRAASVAMIPAAQSRAAVREFHSLYSLAASLVVCSGSVLCFASWANNICNVRKYGRWRFRNTIDDVIMVSDFKTARYIGGFIGFLFYWLIVGPRKYMYESNLADIPGNKRFGPF