wanglab/gogpt-training-data huggingface dataset:
Protein: Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] (P27658)
Organism: Homo sapiens (Human)
Function: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.
Interaction partners:
- Platelet glycoprotein VI
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-3
- Collagen alpha-4
- Collagen alpha-1
- Collagen alpha-5
- Collagen alpha-2
- Collagen alpha-1
- Protein Dr1
Sequence:
MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM
Protein: ABC transporter, ATP-binding protein (A0A0H2UPF2)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKSTFMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLAERQSVRDVLRTAFDELFKAEARINDLYMKMAEDGADVDALMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMDTDVTSLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDIPFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVARNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGYDRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFEQEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRFCLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHEPDFYEGWIDQIWDFNNLT
Protein: Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) (V9HWF0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, myofibril, sarcomere {ECO:0000256|ARBA:ARBA00004204}.
Interaction partners:
Sequence:
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Protein: Probable conserved transmembrane protein (O69637)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible epoxide hydrolase EphE
- Oxaloacetate decarboxylase
- Possible PhiRv2 prophage protein
- Putative acetolactate synthase large subunit IlvB2
- Uncharacterized protein Rv2645
- Putative lipoprotein LppO
- Putative thiosulfate sulfurtransferase SseB
- Putative prophage phiRv2 integrase
- Probable PhiRv1 phage protein
- Possible protease
Sequence:
MSKIDRKNGVPSTLTTIPLADPHAGPAEPSIGDLIKDATTQMSTLVRAEVELARAEITRDVKKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIWRWVAFLLVFAIMVVVTAVLALLGFLKVRRIRGPRQTIASVKETRTALTPGHDKTPVTPKPVTSDRATPVDPSGW
Protein: Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) (Q96J84)
Organism: Homo sapiens (Human)
Function: Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:31472902}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm.
Interaction partners:
- Podocin
- Nephrin
- CD2-associated protein
- Tight junction protein 1
- Protocadherin Fat 1
- Growth factor receptor-bound protein 2
- Kin of IRRE-like protein 3
- SH2/SH3 adapter protein NCK1
- Cadherin-3
- Alpha-actinin-4
Sequence:
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
Protein: Phosphoenolpyruvate carboxylase 2 (AtPPC2) (PEPC 2) (PEPCase 2) (EC 4.1.1.31) (Q5GM68)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Pyruvate, phosphate dikinase 1, chloroplastic
- Malate dehydrogenase, chloroplastic
- Phosphoenolpyruvate carboxykinase 1
- phosphoenolpyruvate carboxykinase
- Phosphoglycerate kinase 3, cytosolic
- Citrate synthase 4, mitochondrial
- Citrate synthase 1, peroxisomal
- Citrate synthase 2, peroxisomal
- Citrate synthase 5, mitochondrial
- Citrate synthase 3, peroxisomal
Sequence:
MAARNLEKMASIDAQLRLLAPGKVSEDDKLIEYDALLLDRFLDILQDLHGEDVREFVQECYEVAADYDGNRNTEKLEELGNMLTSLDPGDSIVVTKSFSNMLSLANLAEEVQIAYRRRIKKLKKGDFADEASATTESDIEETLKRLLQLNKTPEEVFDALKNQTVDLVLTAHPTQSVRRSLLQKFGRIRDCLTQLYAKDITPDDKQELDEALQREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYFSQIEDLMFEMSMWRCNEELRVRAERQRCAKRDAKHYIEFWKQIPANEPYRAILGDVRDKLYNTRERARQLLSSGVSDVPEDAVFTSVDQFLEPLELCYRSLCDCGDRPIADGSLLDFLRQVSTFGLALVKLDIRQESERHSDVLDAITTHLGIGSYKEWSEDKRQEWLLSELSGKRPLFGPDLPKTEEVADVLDTFKVISELPSDSFGAYIISMATAPSDVLAVELLQRECGITDPLRVVPLFEKLADLESAPAAVARLFSIEWYRNRINGKQEVMIGYSDSGKDAGRLSAAWQLYKTQEELVKVAKEYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTIHGQLRVTVQGEVIEQSFGEEHLCFRTLQRFTAATLEHGMHPPVSPKPEWRVLMDEMAIIATEEYRSVVFKEPRFVEYFRLATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGGAFKRVIQKDSKNLNMLKEMYNQWPFFRVTIDLVEMVFAKGDPGIAALYDRLLVSEELQPFGEQLRVNYQETRRLLLQVAGHKDILEGDPYLRQRLQLRDPYITTLNVCQAYTLKQIRDPSFHVKVRPHLSKDYMESSPAAELVKLNPKSEYAPGLEDTVILTMKGIAAGMQNTG
Protein: Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2) (P39087)
Organism: Mus musculus (Mouse)
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17620617}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42260}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 5
- Glutamate receptor ionotropic, kainate 1
- Disks large homolog 4
- Glutamate receptor ionotropic, kainate 4
- Glutamate receptor ionotropic, kainate 3
- Neuropilin and tolloid-like protein 2
- Disks large homolog 3
- Neuropilin and tolloid-like protein 1
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor 2
Sequence:
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
Protein: Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2) (P17971)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells.
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon.
Interaction partners:
- Uncharacterized protein, isoform E
- Uncharacterized protein, isoform A
- Potassium voltage-gated channel protein eag
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL43
- 40S ribosomal protein S24
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL32
- FI01658p
- Large ribosomal subunit protein eL38
Sequence:
MASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNAQNSQNNQPMDGTYLVEASF
Protein: Odorant receptor 67b (Q9VT20)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, pentyl acetate, methyl caproate, anisole, heptanal, 2-heptanone, r-carvone, nonanoic acid, and pyrazines.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 13a
- Odorant receptor 85c
- Putative odorant receptor 69a, isoform A
- Odorant receptor 30a
- Odorant receptor 47a
- Odorant receptor 74a
- Odorant receptor 42b
- Odorant receptor 35a
- Odorant receptor 59a
- Odorant receptor 45a
Sequence:
MQDQLDHELERIDKLPKLGLLWVEYSAYALGVNIAPRKRSSKYCRLTRILVLIVNLSIIYSLVAFIMENYMISFETYVEAVLLTFQLSVGVVKMFHFQNKVESCSQLVFSTETGEVLKSLGLFQLDLPRKKELLSSVSLILLNNWMIIDRQVMFFFKIVCMPVLYYCVRPYFQYIFDCYIKDKDTCEMTLTYPAIVPYLQLGNYEFPSYVIRFFLLQSGPLWCFFAVFGFNSLFVVLTRYESGLIKVLRFLVQNSTSDILVPKDQRVKYLQCCVRLFARISSHHNQIENLFKYIILVQCSVSSILICMLLYKISTVLEVGWVWMGMIMVYFVTIALEITLYNVSAQKVESQSELLFHDWYNCSWYNESREFKFMIKMMLLFSRRTFVLSVGGFTSLSHKFLVQVFRLSANFFLLLRNMNNK
Protein: Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1) (Q9Y2C4)
Organism: Homo sapiens (Human)
Function: Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18187503}.
Interaction partners:
- Zinc phosphodiesterase ELAC protein 2
- Flap endonuclease 1
Sequence:
MAIKSIASRLRGSRRFLSGFVAGAVVGAAGAGLAALQFFRSQGAEGALTGKQPDGSAEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAETFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKAKEQSGTQIRKPS
Protein: DNA-binding transcriptional activator DecR (P0ACJ5)
Organism: Escherichia coli (strain K12)
Function: Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L-cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine.
Interaction partners:
- Multidrug resistance-like ATP-binding protein MdlA
- Regulatory protein AsnC
- Multidrug resistance-like ATP-binding protein MdlB
- Probable serine transporter
- HTH-type transcriptional dual regulator CecR
Sequence:
MLDKIDRKLLALLQQDCTLSLQALAEAVNLTTTPCWKRLKRLEDDGILIGKVALLDPEKIGLGLTAFVLIKTQHHSSEWYCRFVTVVTEMPEVLGFWRMAGEYDYLMRVQVADMKRYDEFYKRLVNSVPGLSDVTSSFAMEQIKYTTSLPIE
Protein: EP2 procyclin (Q389V2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MAPRSLYLLAILLFSANLFAGVGFAAAAEGPEDKGLTKGGKGKGEKGTKVQDEVEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPGAATLKSVALPFAIAAVGLVAAF
Protein: Alpha-conotoxin Pu14.1 (C6ZJQ2)
Organism: Conus pulicarius (Flea-bitten cone)
Function: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. At 1 uM, the synthetic peptide reversibly blocks mammalian nAChR alpha-1/beta-1/gamma/delta and, to a lesser degree, alpha-6/alpha-3/beta-2, but has no effect on alpha-7. At 10 uM, it reversibly blocks nAChR alpha-3/beta-2, but has no effect on nAChR alpha-3/beta-4, alpha-4/beta-2, alpha-4/beta-4 or alpha-6/alpha-3/beta-4. Intramuscular injection of 10-20 ug of the synthetic peptide in goldfish causes death. Intravenous injection of the same doses in Kunming male mice causes unconsciousness. Does not inhibit potassium channels.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P86362}.
Interaction partners:
Sequence:
MGMRMMFAVFLLVVLATTVVSFNSDRASDGRNAAANVKASDLMARVLEKDCPPHPVPGMHKCVCLKTCR
Protein: Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Mitochondrial NAD(+) transporter SLC25A51) (Mitochondrial carrier triple repeat protein 1) (Solute carrier family 25 member 51) (Q9H1U9)
Organism: Homo sapiens (Human)
Function: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:33087354, ECO:0000305|PubMed:32906142}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMDSEAHEKRPPILTSSKQDISPHITNVGEMKHYLCGCCAAFNNVAITFPIQKVLFRQQLYGIKTRDAILQLRRDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSCLLHKHVSAPEFATSGVAAVLAGTTEAIFTPLERVQTLLQDHKHHDKFTNTYQAFKALKCHGIGEYYRGLVPILFRNGLSNVLFFGLRGPIKEHLPTATTHSAHLVNDFICGGLLGAMLGFLFFPINVVKTRIQSQIGGEFQSFPKVFQKIWLERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKVI
Protein: GDP-mannose transporter GONST5 (Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 5) (Q9SFE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GDP-mannose transporter that may be involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:15480787}; Multi-pass membrane protein {ECO:0000269|PubMed:15480787}.
Interaction partners:
- Protein trichome berefringence-like 7
- GDP-mannose transporter GONST3
- GDP-fucose transporter 1
- Pathogenesis-related thaumatin superfamily protein
- Expansin-A22
- UDP-galactose/UDP-glucose transporter 1
Sequence:
MEEGSLWRQWTMFRSLLSILQWWGFNVTVIIMNKWIFQKLDFKFPLSVSCVHFICSSIGAYIVIKVLKLKPLIVVDPEDRWRRIFPMSFVFCINIVLGNISLRYIPVSFMQTIKSLTPATTVVLQWLVWRKYFDWRIWASLVPIVGGILLTSITELSFNVFGFCAALFGCLATSTKTILAESLLHGYKFDSINTVYYMAPFATMILGLPAFLLERNGILDWFEAHPSPWSALIILFNSGVLAFCLNFSIFYVIQSTTAVTFNVAGNLKVAVAVFVSWMIFRNPISPMNAVGCGITLVGCTFYGYVRHMLSQQQPGTPRTPRTPRNKMELIPLVNDKLESKI
Protein: Zinc finger chaperone zpr1 (O13724)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53303}. Nucleus {ECO:0000250|UniProtKB:P53303}. Note=Translocates to the nucleus after nutrient stimulation. {ECO:0000250|UniProtKB:P53303}.
Interaction partners:
- Uracil phosphoribosyltransferase 1
- NAD
- Oxidation resistance protein 1
- DnaJ protein homolog xdj1
Sequence:
MAEEKKEELFTSIGNAAQNVSTAEDREGNGVQEVESLCMECGKNGTTKLLLTVIPYFREVVLMSFECPHCGFKNAQVQHAETIQPEGSKITFHVEDKEDLNRTVVKSQEAIVSIPEIQLEIPGRLGQLTTIEGILSNVVDDLSKEQESRKESAPQLYDQINAFIEKVNSLRSGSVPFTITVDDITGNSWIEMKPGRDGDRWSQVSYKRTLEQNTKLGLVDTDQPEDVKTQTNNASNTLKHDATAVEVDPNEVHTFHATCPSCSHQCDTHMKLLDIPHFKEVIIMSTVCDRCGYRSNEVKTGGEIPPKGRKITLKVMDAEDLSRDILKSETASLKIPELGLDLFPGTLGGRFTTIEGLLAQVYDELYGRVFSQETDSMTPEQVANWQQFLCNLTAAREGATQFTLILDDPLSQSYLQNYYAPDPDPNMTIEEYERSFQVNEELGLNDMKTENYEKDGGKK
Protein: DNA damage-inducible transcript 3 protein (Zgc:162630 protein) (A3KNX2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTAEWLYPPGVGPLCGAELEAWYEDLQDILGSDTGGAKLTRAPPSSEKEPEFLDVLESCSLTWLTEGQVWGDGVQRVTEDPPVHQSPPRQEERTTENTSSGDLLPPEFFELLSEGGVGDTMVNGGAGYHLHAPPSPAASEEEELPTVPDTSSCSSASRSPSLNCSPPASPPVSSSRKRKRGGALCSASPGKKSRREREQENERKV
Protein: PHD finger protein 14 (A0A286Y9D1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone-binding protein. Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9D4H9}.
Interaction partners:
- Histone H3.3
- Histone H3
- Histone H3.2
- Si:dkey-108k21.24.
- Histone H3
- Histone acetyltransferase
- High mobility group protein 20A
Sequence:
MDRGSKRRQVKPLADSLLDALDYDSSDDSDFKVGESSGSEGTGNGSDEEGSKESAAGSESDSDAAAASADEEGIDDLETKDLNQEDDEEEKVKESFSEETSSKETGGSSRSRKKGEKSSDMEPNGSATTEENSAEPKKWNLRRNRPMLDFTTMEELNEMDDYDSEDDNDWRPTQGKKKGKASSGKEKEGSGEEDDDDDDGGSDEEDNEDDNDDDDDDDDEGNDDESSSSDSEEEGKKPKKKAGKNTGAFDEEETNDSHSTSHGKGNEDSLLERPQTWSSQRMEHILICCVCLGDNSEDADEIIQCDNCGVTVHEGCYGVDGESDSIMSSASENSTEPWFCDACKNGVSPSCELCPSQDGIFKETDAGRWVHVVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSLCEDTRFARTGVCISCDAGMCRSFFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRFDRKWKRKNYLALQSYCKVSLQEREKQLTPEAQARITTRLQQYRAKAELSRNTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDTSDISASVDGRRKHKQPALTADFVNYYLERNMRMIQIQDNIVEQKNLKDKLESEQEKLHMEYDKLCESLEDLQNVNGQLRTEGQSIWSMMGGIVGQKLNVPAVLKAPKERKPSKKEGGSPGKSSSLPAMLYSCGICKKNQDQHLLLLCDTCKLHYHLGCLDPPLTRMPKKTKNSYWQCSECDQASSDEADIAMETLPDGTKRSRRQIKGPIKFIPQEMSPEPKKPQVRGTRTRGQKRKRMSICEEEKMEEPLPRERRQRQSTLQKKPKADDTRTECTTCKGPGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDTSSSKEEEAQEVEEESVNEETAEQEIPD
Protein: Probable inactive poly [ADP-ribose] polymerase SRO4 (Protein SIMILAR TO RCD ONE 4) (Q9STU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable inactive ADP-ribosyltransferase that may be involved in stress and developmental responses.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic
Sequence:
MDYSKTEETPINEEQGSTNSSESRSNEELFSDCDQQHSSIANEFGLTELPKDDKVYELIYRHCQSKLTSHLSNQFEIVSILKNGFQTPLGQAKLKAFQIYAESVAKKSGSCCGNKAAVAEAARVKYGCCGVEKEELKAILMYGFSNNALCLSPDNAPLQCMIDPSSSCNEDGISFLLFSRIIMGKSEVVCSTSQSYPSSMEFDSGVDSLTSPNKYIIWSTHMNTHVLPEFVVCIKTPSILKRKNPKSPWISFPVLINSISKFLNQSQIRLIHKHYKEHQDRRISRCELIQRLRSITGDSLLVQIIKSVGQKVHKDT
Protein: Nuclear transcription factor Y subunit C-10 (AtNF-YC-10) (Q58CM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear transcription factor Y subunit B-3
- DNA polymerase II subunit B4
- Nuclear transcription factor Y subunit A-2
- Nuclear transcription factor Y subunit B-1
- Nuclear transcription factor Y subunit B-2
- Nuclear transcription factor Y subunit B-4
- Nuclear transcription factor Y subunit B-10
- Nuclear transcription factor Y subunit B-5
- Transcription factor bHLH144
- Nuclear transcription factor Y subunit A-1
Sequence:
MRRPKSSHVRMEPVAPRSHNTMPMLDQFRSNHPETSKIEGVSSLDTALKVFWNNQREQLGNFAGQTHLPLSRVRKILKSDPEVKKISCDVPALFSKACEYFILEVTLRAWMHTQSCTRETIRRCDIFQAVKNSGTYDFLIDRVPFGPHCVTHQGVQPPAEMILPDMNVPIDMDQIEEENMMEERSVGFDLNCDLQ