wanglab/gogpt-training-data huggingface dataset:
Protein: Biopolymer transport ExbD protein (B3GYQ2)
Organism: Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004249}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004249}. Cell membrane {ECO:0000256|RuleBase:RU003879}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU003879}.
Interaction partners:
Sequence:
MAFGSFDKNENSVMSEINVTPLVDVMLVLLIVFMITMPILTQSIPLELPTSSIEKKDEPKDIFRVAINPTGIYLGEKLVNEEELKQSFLTKFQENKNTVIAISADISVEYQHIVKVLELAQNVGLTKIGFVTQPSK
Protein: UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) (Q96QD9)
Organism: Homo sapiens (Human)
Function: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:19836239}. Nucleus speckle {ECO:0000269|PubMed:19836239}.
Interaction partners:
- Spliceosome RNA helicase DDX39B
- SAP domain-containing ribonucleoprotein
- Nuclear RNA export factor 1
- Chromatin target of PRMT1 protein
- Polymerase delta-interacting protein 3
- THO complex subunit 5
- THO complex subunit 4
- THO complex subunit 1
- THO complex subunit 2
- THO complex subunit 7
Sequence:
MNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKREQSDVKKVPKGVPLQFDINSVGKQTGMTLNERFGILKEQRATLTYNKGGSRFVTVG
Protein: Uncharacterized protein (Q580J1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- Transcription initiation protein, putative
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Plastid-encoded RNA polymerase subunit alpha
- DNA-direcetd RNA polymerase II, subunit 9, putative
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- Spt4/RpoE2 zinc finger domain-containing protein
- Telomerase-associated protein, putative
Sequence:
MGEVMILREKQEDSMIVLSGVRKQADLLLMSRYFVKLQRHVEKGKRKKHLGRCATLLKHNAVRRLVVTHFLRWFYNTRRHLAGSLGFEGLPRIVVFPTNQDFVNLGVRYFQQWREWLRRIRQRRCTNTELLKNKTRERQLLCSFHQWRCFVHQQREERLARRLYELTQQNEKLLTDIEMMEQHCEGQQEREEAFKSLLTNMEAHRNRQFRELENYRQAVREAVSLLHVSSWAETNSQGVAPQAEKGQNVLSDSVGDEESLQLLRAAATDVHKAVSELRSVLPMENEGSGTLSDVVQSVCQHISKLDGTFDELMDELHSSSTLTKYMRNVLQSTGENILAISQKCSPPNLFRGRVNNFNQTPTPEQSREPHRHNVTGGSFVDWETLELLKDQLSHGDTLMNGVPSTVAVLENVDDALKCLYERQQEADEYMSNQQKTANCTREQVHVLAEAAEQAVGLIQSWCSMTAQHQRDTTTIDAKEELTGVKVCELAALLRYESEVASDALSKIRHILLSTRPPPKMSAQDVQSKVPSTGDASTETSRFVSYSGLVKMVQGLHEQQKEAVDAYETVYNELQQLIFDLSAIGSGRESCASVSSESCNDSRLNSLERPQLSISRNTSDYLHYPMKRAEPIINAVRDCINLKDIELKELRSVIRRSVVALSGGTYDGEEFLGENNGINSSVARFPEGTRLLTMCEELGRAVMEAKTAMKANDTGKFCMHDMVVQLQNKLKGLQMVEAECVSLMKGLNHVSTLYDNGVETEGRSSVAAMLRRWELTTVEQKVGVVDEQTSKVVASRHENIPVGGNDDDAMRCSEILRTLLRGVRRTAEEFLGLHGACAELLTVLDGTHVGPTHLHTPPCDRDMIQSLARHTKELKKVLNRHAAETSDKSSWKGSVSDRLVMLTAKVALLQSEKETLRDEVARCTDRHSSLIKKLTKEVDRLNQVNQKLLDGTEKLSEQKGIEERLARRRAVHIARLLERVVPRVRLGGCLVLWMKYVCERRKQAVYDAREAEETNSLQVARKQHQQNLILRMLAVVLNSLPSTSSLESEAPVTELLLLHLIRTENHDCLDELVQRRLGAVAVWRRSLKELLRDAAALKEEAWSLREAMTGSWKTQLGGLLHEVSDGIHTAVAFVNEQRSMNNEALRNQVLGTETLSRKNRELKRNNTKLLQELLELQRVIATRDERIIKLERENRNIQLSCILTDNDSSTTIGEGKKDDYHRSVVAANTHWHDQERAERVMVSSAKRLAVETINAIAGKDSVGSIAEVAELTAELYNRTAVSLEAICNAHPAARRDFLQVAEACLADLQNLQEVRHEIVERLPELLRVPYID
Protein: Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1) (Q8TC12)
Organism: Homo sapiens (Human)
Function: Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal. Has no dehydrogenase activity towards steroid.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12036956}; Single-pass type II membrane protein {ECO:0000269|PubMed:12036956}.
Interaction partners:
- Retinaldehyde-binding protein 1
- Lecithin retinol acyltransferase
- Retinoid isomerohydrolase
- Retinaldehyde dehydrogenase 3
- Retinol dehydrogenase 10
- Cytochrome P450 26A1
- Aldehyde dehydrogenase 1A1
- Retinal dehydrogenase 2
- Beta,beta-carotene 15,15'-dioxygenase
- Retinol dehydrogenase 5
Sequence:
MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGLPID
Protein: AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) (Q96FJ0)
Organism: Homo sapiens (Human)
Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains.
Interaction partners:
- Polyubiquitin-C
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Zinc finger-containing ubiquitin peptidase 1
- COP9 signalosome complex subunit 5
- Clathrin heavy chain 1
- Ubiquitin-like protein FUBI
- Clathrin interactor 1
- 26S proteasome non-ATPase regulatory subunit 4
Sequence:
MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSICKHVLVKDIKIIVLDLR
Protein: Uncharacterized protein C12C2.04 (Q09745)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Glutamyl-tRNA
- Zinc finger protein grt1
- ATPase histone chaperone abo1
Sequence:
MTALSTNSSSGGIFKIAIVGAGGINFGTPEGPWNNAQRVEKVLGKSLRVTALINPLINESERVLKSKCASDVAFAYENTKTYVSVTEYLEYLDSHPEDVPSAYLIGIPPDFHGCTTPGMDMELEILRKYPNAALFIEKPITSAPVQGAFNLVHELEKYHAIISIGYMFRYLKIVQAAKKYVADNNLNIACTIARYNSAYEHNNKLFWWYMSKSGGPVVEQATHFCDLSIYFGGDVDTSTVKVNRVNWYDPCGKLAKVPVDEESIPKEERIPRFTAASWKYKSGAVGILAHSIILQGTNYDTCLELQADGHYVRMVDFYGQPRLYIRSPEADSERIINFPEDDPYYNEFDAFLGVVQGRYPPSRILSKFDDGAKTYELTKIITNN
Protein: Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein (Q38AB2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
Interaction partners:
- Uncharacterized protein
- Vps53 N-terminal domain-containing protein
- Vacuolar protein sorting-associated protein 51 homolog
- COG4 transport protein middle alpha-helical bundle domain-containing protein
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 3
- Small GTP-binding protein RAB6, putative
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 5
Sequence:
MSTGHPVDCVPLHQAAESCDPVAKLCAFLMAKRGWSHHRLAQALGVPPLVLEECIRNGVSSGALHGRLARWIAEGGGASLPQSLVQAVVQAPAGILSGSDTPESQLDGDPLADLDPVTRAYFVELGSSIGQSFISILNDPRQARDNFRWGSWFVGIVSNALDHKTYMKRAGTVTNEQPSSDTLMARYNQNWDYMPYLQLVSGTLSENNKGVEPLANVPAATPQLGSVLSCALNENLPWPQGVPEEFFDTSYDAANELRLLERVIEERGGSKIDEDGVPITATTFSDDFEEIEKRMKKLREWEGAVESCLLRHVQSRADQFFIVSQDFTDRAGEARRALDDLQQTRADVDAYGTGFVREMMTIAQNYRIRHGLTASRDLAVGMMETLSALSVNENWISLPERDMTELPAVVENYCALYKALWCGAAAGAGEANNNNNNNNNNNNNFSETGNFTRVRVLRDVPERMLLAKESLHKMIMREIELTFNPLPGSDVEEGRLLRAVRAAGEMNLLPTIIHQNRERLPDIMWTNARSVFVTGMMDSGAVGEKGANSLLEVAVAGDSSREEKLSLIGLSDSCRFPAFMRIFSAIAVQISQAVRQASRCWALLVVGASVRSSFRDVGAHDGEESLWDMSRRNLVALFAAAEGTVALFLEARSRPSCVPTNVHDLETLVKSGYDFMQGMVAVFHDVAAMVGDLGDPWSCLSGKQLKAAVVRLGKEHVRSRHAANIERIRLTLEGEKWVPCDSDADFQSRVSVIFNGGDEAVSALRALIVFTDFKDSRETHPSSPKTCQEMAVAPSKKPDAVPDLNFTAVGEGKVNKPFILPSLGGQFDGRVVSVSLQILLEMLHDYDGYLGRFPFLAFDIMGKVYDLLRLYNSQCAALLLGAMAVETGTLESITVPHMAVASQNLALLYDGIPLMQRRWERVVDGDNLPSSISEDLERVRQGCQMCRLELLGKIAALVKEKVGVLADTARREWQDAGSPWVMTTLRETARVMHLLNPLVPVSDCRGVVVPMLGTFARMMRTVMMSPDIDEVELGVMRSDVLVFKANVERFGFDVMRCMELCASPTDAMKESKEPCATDEAVLAWFFGQA
Protein: Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) (P60853)
Organism: Mus musculus (Mouse)
Function: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDIGGQTGVDFDPATPPKLMPFSNQLEMSSDKGAVRPTAFKPVLPRSGAILHSSPESTSHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKADKGASCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPPSQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQLEVNTKASEILSLKAQLKDTRGKLDGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELMELRAQAALHPAPLGPPGVGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQRQLQQSYLAMYQRNQRLEKALQQLARGDGPGEPFEIDLEGADIPYEDIIATEI
Protein: Gephyrin a (Gephyrin1 isoform) (D3KYK9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASDGMILTNHDHQIRVGILTVSDSCFRNLAEDRSGINLKDLVHDPSLLGGIISAYKIVPDEIDEIKEILVDWCDEKELNLILTTGGTGFAPRDVTPEATREVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDALEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEDEEKKDSGVASTEDSGSSHITAAAIAAKIPESIISRGVQVLPRDTASLSTTPSESPCAQQSRLSTASCPTPKARLTSCSSTYSVTEASRREFRAHLDDVISHKSRYSTLDQLHSRLEGLKDDRRNHRTFDSRVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTLTVMPGQVMRVTTGAPIPCGADAVVQVEDTELLRESEDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVQKFPVVAVMSTGNELLNPEDDLHPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGARKLIFALPGNPVSAVVTCNLFVIPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
Protein: Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase SHP-1) (P81718)
Organism: Rattus norvegicus (Rat)
Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17068200}. Nucleus {ECO:0000269|PubMed:17068200}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK (By similarity). {ECO:0000250}.
Interaction partners:
- B-cell receptor CD22
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Cd72 molecule
- Tyrosine-protein kinase
- Proto-oncogene vav
- Lymphocyte cytosolic protein 2
- Killer cell lectin like receptor C1
- Programmed cell death protein 1
- Protein kinase C theta type
Sequence:
MLSRGWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAAPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEAKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKASRTSSKHKEEVYENVHSKNKKEEKVKKQRSADKEKNKGSLKRNISLTPCRGLRWADRDL
Protein: Bursicon (Bursicon subunit alpha) (Cuticle-tanning hormone) (P84118)
Organism: Periplaneta americana (American cockroach) (Blatta americana)
Function: Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading.
Subcellular location: Secreted {ECO:0000269|PubMed:12271490}.
Interaction partners:
Sequence:
GTVFFDQDSPDSPVKVTGEVTGLQKHGFHIHEFGDNTNMSADGSSYLQVSGSKLTQEGQASMEVKGNAGARVAXGVVGIAK
Protein: At1g49010 (Duplicated homeodomain-like superfamily protein) (F27J15.20) (MYB transcription factor) (Q9M9A3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Homeodomain-like superfamily protein
- Duplicated homeodomain-like superfamily protein
- Protein REVEILLE 5
- Ethylene-responsive transcription factor ERF039
- Transcription factor HHO5
Sequence:
MESVVATWSREEEKAFENAIALHCVEEEITEDQWNKMSSMVPSKALEEVKKHYQILLEDVKAIENGQVPLPRYHHRKGLIVDEAAAAATSPANRDSHSSGSSEKKPNPGTSGISSSNGGRSGGSRAEQERRKGIPWTEEEHRLFLLGLDKFGKGDWRSISRNFVISRTPTQVASHAQKYFIRLNSMNRDRRRSSIHDITTVNNQAPAVTGGGQQPQVVKHRPAQPQPQPQPQPQQHHPPTMAGLGMYGGAPVGQPIIAPPDHMGSAVGTPVMLPPPMGTHHHHHHHHLGVAPYAVPAYPVPPLPQQHPAPSTMH
Protein: Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28) (O75586)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 31
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 26
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 22
Sequence:
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ
Protein: Transcription factor bHLH149 (ATBS1 interacting factor 4) (Basic helix-loop-helix protein 149) (AtbHLH149) (bHLH 149) (Transcription factor EN 144) (bHLH transcription factor bHLH149) (O80482)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical bHLH transcription factor probably unable to bind DNA. Negatively regulates brassinosteroid signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH146
- 2-oxoglutarate
- Activator of spomin::LUC2
- Transcription factor bHLH110
- Transcription factor bHLH118
- Myb family transcription factor PHL11
Sequence:
MVESLFPSIENTGESSRRKKPRISETAEAEIEARRVNEESLKRWKTNRVQQIYACKLVEALRRVRQRSSTTSNNETDKLVSGAAREIRDTADRVLAASARGTTRWSRAILASRVRAKLKKHRKAKKSTGNCKSRKGLTETNRIKLPAVERKLKILGRLVPGCRKVSVPNLLDEATDYIAALEMQVRAMEALAELLTAAAPRTTLTGT
Protein: Keratin 83 (Type II keratin Kb23) (A7M776)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTCGFQTGNFGCASACGPRPGRCCITAAPYRGISCYRGLSGGFGSRSVCGAFRSGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKHEEKEQIKCLNSRFAAFIDKVRFLEQQNKLLETKWQFFQNRKCCESNVEPLFEGYIETLRREAECVEADSGRLAAELNHAQEAMEGYKKRYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANAEALTQEIDFLRRLYEEETRILHAHISDTSVIVKMDNSRDLNMDCVIAEIKAQYDDIASRSRAEAESWYRTKCEEIKATVIRHGETLRRTREEINELNRIIQRLTAEIENAKCQNTKLEAAVTQSEQQGEAALTDARCKLAELEAALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCSGNVAVSTGLCAPCGSGPCHQGRC
Protein: Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (Q8RY94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Adenylosuccinate synthetase, chloroplastic
- AICARFT/IMPCHase bienzyme family protein
- Phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic
- Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial
- AMP deaminase
- Adenylate kinase 1, chloroplastic
- Adenine phosphoribosyltransferase 1, chloroplastic
- Adenylate kinase 3
- Adenylate kinase 2, chloroplastic
- Adenylate kinase 5, chloroplastic
Sequence:
MELNFSSMAITHPKIPSFGFTPTGIFLNPSKSVCLASHHRLPRVSCSVSTTTDSPKLVTSTKVTAMDGVSSRDLEMSNLTALSPLDGRYWSKVKDLASSLSEFGLIYFRVFVEIKWLLKLSNIPEVTEVPSFSKEAQSFLQGIIDGFSIDDALEIKKIERVTNHDVKAVEYFLKQKCESQPEIAKVLEFFHFACTSEDINNLSHALMLQEALSSVILPTMDELIKSISLIAKNFAYVPMLSRTHGQPATPTTLGKEMANFAVRLSEERRYLSETKIKGKFAGAVGNYNAHISAYSNIDWPHVSEEFVTSLGLTFNPYVTQIEPHDYMARLFNNISQFNTILIDFDRDIWSYISLGYFKQTTKAGEIGSSTMPHKVNPIDFENSEGNLGKANAELTFLSMKLPISRMQRDLTDSTVLRNMGGALGHSLLAYKSAIQGIGKLQVNEARLKEDLDDNWEVLAEPIQTVMRRYGVPEPYEKLKELTRGKAVNEETIRTFIKGLELPSEAKDQLLELTPHTYVGAAAALALAVDEALHLGH
Protein: Meiotic driver wtf4 (Q9P3V0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus; the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, leading to poisoning of all progeny that do not inherit the allele.
Subcellular location: [Isoform 1]: Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. {ECO:0000250|UniProtKB:A0A218N034}.; SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm {ECO:0000250|UniProtKB:A0A218N034}. Cytoplasm {ECO:0000250|UniProtKB:A0A218N034}. Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1. {ECO:0000250|UniProtKB:A0A218N034}.
Interaction partners:
- Wtf element wtf14
- Wtf element wtf11
Sequence:
MKNKDYPLRSSMDELSTKNDNEIDLEKGPLPEYNSEDGSTLPPYSEIWKYIKTVSEDSSTGPTEIANPNVERRQEFKDSHPNIYSLLRLLISVLAVIVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPIVFIVIFCFFETWTQAVAQCIKVTVIFLAQCVKVTAVFLAKCVKVIAVGLYNSKKDLVVTIWLAWVVICFILFGCVKDGRLNLNKALICSTCSISAALFFILLLVCIPIWTLKHMLFGLFQVLGVQSCVVIVTKGLMYLFDKHIDATGYEIEASSLFVIGNFLFFYEMERPGALKRMPKFIGNGIASFLGGLGNAFGGIGNAFGGIGNAIGRIGNAFRGANDNNDIPLGEMDVESEV
Protein: Protein Scribble homolog let-413 (Lethal protein 413) (Protein lap-1) (O61967)
Organism: Caenorhabditis elegans
Function: Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical junctions.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:10878806, ECO:0000269|PubMed:11493666, ECO:0000269|PubMed:14578922, ECO:0000269|PubMed:19109941, ECO:0000269|PubMed:27506200, ECO:0000269|PubMed:34673778}; Peripheral membrane protein {ECO:0000269|PubMed:10878806, ECO:0000269|PubMed:14578922}. Note=Basolateral membrane of epithelial cells. {ECO:0000269|PubMed:10878806, ECO:0000269|PubMed:11493666, ECO:0000269|PubMed:14578922, ECO:0000269|PubMed:19109941, ECO:0000269|PubMed:34673778}.
Interaction partners:
- Disks large homolog 1
- Protein lin-2
- Protein kinase C-like 3
- Apical junction molecule ajm-1
- Moesin/ezrin/radixin homolog 1
- Alpha-catenin-like protein hmp-1
- Partitioning defective protein 6
- Abnormal pharyngeal pumping eat-20
- MAGUK p55 subfamily member 5
- Intermediate filament protein ifb-2
Sequence:
MPAFFCLPMACQRQVDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSLNETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNLTSEIGKCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSILKLSETRDDRKGIKVVTCYLLPQVDAIDGEGRSGSAQHNTDRGAFLGGPKVHFHDQADTTFEENKEAEIHLGNFERHNTPHPKTPKHKKGSIDGHMLPHEIDQPRQLSLVSNHRTSTSSFGESSNSINRDLADIRAQNGVREATLSPEREERMATSLSSLSNLAAGTQNMHTIRIQKDDTGKLGLSFAGGTSNDPAPNSNGDSGLFVTKVTPGSAAYRCGLREGDKLIRANDVNMINASQDNAMEAIKKRETVELVVLRRSPSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS
Protein: Proteobacterial sortase system OmpA family protein (Q966J4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTDNYLRQVIDHAQNNQRLRGTMSGIFYQTAYAAAGAGAGGLMAGPLGAMFGTMAGAVYGYANSDDYSSVFGIIQNLEDEEKDILTSTIRNHVGGLTFAEFVNWFKDLNHQATFMQLLMAYMAANQKSAGTSRR
Protein: Sorting nexin-10A (F1Q506)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
Subcellular location: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 35
Sequence:
MDNTSFEKREFISVWVRDPQVHKEDFWHTYISYEICLHTNSMCFRKKTSCVRRRYSEFVWLRHKLQDNALLIELPKLPPWNPFFNLNNEFHITQRMQGLQQFLEAVLQTPLLLSDSRLHLFLQSQLSIAKMDACAQGHTHYTVAQAIQRCGGEARFPVEEQHQEDSKTCCDSDCDSTTSSGLGCSIEPATLVEQDLSHNERFAHEFQATNPEAELCSSLSSSPHGHSVI