wanglab/gogpt-training-data huggingface dataset:
Protein: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24) (Q64441)
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q09128}.
Interaction partners:
- Vitamin D 25-hydroxylase
- 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
- Vitamin D-binding protein
- Fibroblast growth factor 23
- Sodium-dependent phosphate transport protein 2A
- Vitamin D3 receptor
- Parathyroid hormone
- Sodium-dependent phosphate transport protein 2C
- Adrenodoxin, mitochondrial
- Klotho
Sequence:
MSCPIDKRRPLIAFLRRLRDLGQPPRSVTSKAHVKRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFMGQIDELRDERGRIQDLYSELNKWSFESICLVLYEKRFGLLQKDTEEEALTFIAAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDHRLERYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRLLREIQSVLPDNQTPRAEDVRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYTLPKGTVLTLNTQVLGSSEDNFEDADKFRPERWLEKEKKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIIQKYNIVATDSEPVEMLHLGILVPSRELPIAFCPR
Protein: Nucleosomal histone kinase 1 (EC 2.7.11.1) (Protein baellchen) (Q7KRY6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis-specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15078818}. Nucleus {ECO:0000269|PubMed:15078818}. Chromosome {ECO:0000269|PubMed:15078818}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:26251439}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:26251439}. Note=Chromatin-associated during mitosis (PubMed:15078818). In indirect flight muscle, colocalizes with sls isoform A (kettin) to the sarcomere Z lines and appears to be weakly distributed across the sarcomere (PubMed:26251439). More rarely, localizes to M lines (PubMed:26251439). {ECO:0000269|PubMed:15078818, ECO:0000269|PubMed:26251439}.
Interaction partners:
- Barrier-to-autointegration factor
- Ankyrin repeat and LEM domain-containing protein 2 homolog
- non-specific serine/threonine protein kinase
- Rac GTPase-activating protein 1
- Protein claret segregational
- Ras-like GTP-binding protein Rho1
- Dual specificity protein phosphatase
Sequence:
MPRVAKPKAAAPAKKVVSAKKAKSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPDPKKMHNGTIEYTSRDAHLGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKRVADSSPPSQKRVKTEPKSTPRERATPKASPKPRSTPKASPKPQTPTAARLRTPNAKINFSPSISLRGRPGGKTVINDDLTPQPRSKKTYEFNFELDVSMDANVIVNVKRKKKADQDKATAVDSRTPSSRSALASSSKEEASPVTRVNLRKVNGHGDSSTPGRSPRTPAVTVRKYQG
Protein: LL-diaminopimelate aminotransferase (DAP-AT) (DAP-aminotransferase) (LL-DAP-aminotransferase) (EC 2.6.1.83) (Q58786)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Diaminopimelate epimerase
- 4-hydroxy-tetrahydrodipicolinate reductase
- Uncharacterized metallohydrolase MJ0457
- Diaminopimelate decarboxylase
Sequence:
MESYIQNLFAERIGGKKFGKEDVIYKFEKIKRAKQEAMKRHPDMELIDMGVGEPDEMADPEVIRVLCEEAKKWENRGYADNGIQELKDAVPPYMEKVYGVKDIDPVNEVIHSIGSKPALAYITSAFINPGDVCLMTVPGYPVTATHTKWYGGEVYNLPLLEENDFLPDLESIPEDIKKRAKILYLNYPNNPTGAQATKKFYKEVVDFAFENEVIVVQDAAYGALVYDGKPLSFLSVKDAKEVGVEIHSFSKAFNMTGWRLAFLVGNELIIKAFATVKDNFDSGQFIPIQKAGIYCLQHPEITERVRQKYERRLRKMVKILNEVGFKARMPGGTFYLYVKSPTKANGIEFKTAEDFSQYLIKEKLISTVPWDDAGHYLRLAACFVAKDENGNPTTEEKYEDMVLEEFKRRLEGMDLEFE
Protein: Connector of kinase to AP-1, isoform A (Connector of kinase to AP-1, isoform B) (Connector of kinase to AP-1, isoform C) (Connector of kinase to AP-1, isoform D) (DCKA) (LD41760p) (Q9VLT9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGTNSGATAGINNKPVGGATGAGVLVGGGVGGANSSIGGVLSNSLGGGGSGGLSISGLNAGGQNANVGGMGNVGGDDGGNGMVGGGVNNQQATTPQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKMLEYALRQERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATDSEVPYSSVSNTTWRQGRQMLRQYLAEIGYTDNIIDVRSNRVRSILGLNNNAEHDGSGGGLGGGLGGGTGGENLSPNINGNESNKRASETEGRHTPAKKVQQSIDEIIVDTEAAVMANFEFLGATEMSDDDEISDDLEMVATDNDDTDVKLAKRAKSGKDMLTEEVDGSLGLGELAQLTVNNESDGAYDANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECWQLPSPNIDPYDCYDPNVHSGTLEGHTDAVWGLTTMQSNIVSCSADGTVKLWSPYNKEPLLRTYTASEAEGVPSSVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKFINKVVSHPTLPITITAHEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHRKKFDESIFDVAFHATKPYIASAGADGLAKVFV
Protein: Frizzled class receptor 3 (A0A8I5ZWZ3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAVSWIVFYLWLLTVFLGQIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFHGRKKKETVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLHRSRDGREPKLCV
Protein: Lethal (3) neo38, isoform F (Lethal (3) neo38, isoform I) (A0A0B4K6F4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQYGQNISIPYSQPQGDLNFLNAAAAADHKGKIHPKIERDREEVLNQQILQNVNQSWQTLANTANTVDYSSHLLSATLPISIQHFLKYSETIKKESTGDVLKNGTNLASLALGGVALTPSNNGANGGHHNGLVGMDHGGHMTNMTDANGAALTNGASNGVNGNANGTVTNGGAGAVSSSGSVGTTNASGGTGTASGKKTKKKKPPKEKKPRPKPGEIRETKALDGSTLYCCPECQMAYPDRSLIEQHVISHAVERRFVCDICNAALKRKDHLTRHKLSHIPDRPHVCNICMKSFKRKEQLTLHIVIHSGEKKHVCIECGKGFYRKDHLRKHTRSHIARRVKSEVSAQNVNGSAGGGGGGGGGNSAQSNALHGS
Protein: NADH-ubiquinone oxidoreductase chain 6 (EC 7.1.1.2) (NADH dehydrogenase subunit 6) (P03925)
Organism: Mus musculus (Mouse)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acyl carrier protein, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4L
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 2
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase iron-sulfur protein 5
Sequence:
MNNYIFVLSSLFLVGCLGLALKPSPIYGGLGLIVSGFVGCLMVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWLILGFLVLGVIMEVFLICVLNYYDEVGVINLDGLGDWLMYEVDDVGVMLEGGIGVAAMYSCATWMMVVAGWSLFAGIFIIIEITRD
Protein: Uncharacterized protein C20F10.03 (O42973)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL18A
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL39
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS15
Sequence:
MGKKDGKRQLMSDDDSFDTISILSGSMDQLSVGSMEDSGILKGSKTWLEELESTIDDLIEVKKIGAKEREEHLEKIYVICTRHYAKRISENVASLEELLLKIFNGPRSDKELILTIRIMCTFCLASVFQVEELWTKTEGRFNALANDAESSGIKCESILCFSLLTALLDSEADVIEFGDFLISILESDGAVVNSEDDEGVVGCACQALGLLLTCVTTESEFLASAAEALSEQLDAASIDVQLAAGQALAALFERVNEIRPDKDEENDESDVSQTSKFDDIIPDRNQLLITLRDLASESSKSIGKKQRKVLHQVFRNVLQTIEEPNARNILRNSVRIGQSTVQLDSWKKILRAQMLRYVLGSSFSEYFAKSTFIRYFLGYSGYVAGLSSRDPDSDFDSDNVDEYIDDHKRGLSSTERRDLDRVRDKQKKQDQRVRADYINSVYFSQN
Protein: F-box/kelch-repeat protein At2g44130 (O80582)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box/kelch-repeat protein At1g23390
- At3g13310
- Phosphatidylinositol N-acetylglucosaminyltransferase, GPI19/PIG-P subunit
- Probable ADP-ribosylation factor At2g15310
- Transmembrane protein
- Receptor-like protein 34
- Defensin-like protein 207
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- At2g17880
Sequence:
MTMEVSKKKGGDFQQCHELIPGLPSELALECLVRVPFQFQSAMRSVCRSWRSLLSDSSFIQERRRCGKTELLLCLVQPLTPPIPASKSVDETLMVDEKKSEDESHPRVFCTPRFGLSVYNAAMSTWHRVAFPEEEQIPLFCECVVLQDAGKILLIGGWDPETLQPTRDVYVLEFAGRKWRRGAPMKESRSFFACASVSPTKVYVAGGHDDQKNALRSAEVYDVEKDEWSSVTPMTEGRDECQGFAVGMGLRFCVLSGYGTESQGRFRSDGEIYDPATDSWSRIDNVWRFPDTSPRGRTAGDFRSSSTLWCFTDTDLQSERRWETNDDSRNLKLDLQSIQLPMTGSSVFAGSLGGESVVMIGGKRESEGEGEGGVMMKMTTEKKMGKWSHHVHIPCDFSTLPFSHASIYV
Protein: DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) (Q3T0X9)
Organism: Bos taurus (Bovine)
Function: As a component of the tetrameric DNA polymerase delta 4 complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9HCU8}. Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. {ECO:0000250|UniProtKB:Q9HCU8}.
Interaction partners:
- DNA polymerase delta catalytic subunit
- DNA polymerase delta subunit 3
- DNA polymerase delta subunit 2
- DNA ligase
- DNA polymerase alpha subunit B
- DNA polymerase epsilon subunit 2
- DNA polymerase epsilon subunit 3
- Mitotic spindle assembly checkpoint protein MAD2B
- DNA polymerase epsilon subunit 4
- DNA-directed RNA polymerase III subunit RPC9
Sequence:
MGRKRLITDSYPVVKRREGSAGHSKGELAPDLGEEPLPLSVDEEELELLRQFDLAWQYGPCTGITRLQRWHRAEQMGLKPPPEVHQVLQSHPGDPRFQCSLWHFYPL
Protein: Rad, Gem/Kir family member 1, isoform C (A0A0B4KFV9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAPFYKRICRSLSKRYKEPSLSLDNTVETLLIKNEGDFISVEQGKELVARKRNSQQLAHPPAHLHHHTQNHAHNHHTLQQQQHQQQQQQQHKRDENMRQLLDVTNTLTIEELRDFQMRYGSPHHSRSQSVKMPGSRASGRPNQLCLPQQRSRVASMPNTGVEEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSVASSNSSTEHLTTQQQLSAPASVSARTSLASSRESSTSNPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDLGNCDIRILIEKAADDDESGEKAVSVLLSGEESELIFIDHGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLKLENPEKSRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGPLGEAVATPPGSAQSSPRKYRGSRTSTSLKVKGLLGRVWTRDSKSKSCENLHVL
Protein: Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase) (P05093)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:2808364}. Microsome membrane {ECO:0000305|PubMed:2808364}.
Interaction partners:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- 17-beta-hydroxysteroid dehydrogenase type 3
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- Cytochrome b5 type B
- Cytochrome b5
- Aldo-keto reductase family 1 member C3
- 17-beta-hydroxysteroid dehydrogenase type 2
- Aromatase
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
Protein: Testis-specific H1 histone (Haploid germ cell-specific nuclear protein 1) (Histone H1.7) (Histone H1t2) (Q75WM6)
Organism: Homo sapiens (Human)
Function: Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8CJI4}. Chromosome {ECO:0000250|UniProtKB:Q8CJI4}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250|UniProtKB:Q8CJI4}.
Interaction partners:
- Histone H1t
- Histone H1.8
- Histone H1.10
- Histone H1.1
- Histone H1.4
- Histone H1.5
- Histone H1.0
- Histone H1.3
- Histone H1.2
Sequence:
MEQALTGEAQSRWPRRGGSGAMAEAPGPSGESRGHSATQLPAEKTVGGPSRGCSSSVLRVSQLVLQAISTHKGLTLAALKKELRNAGYEVRRKSGRHEAPRGQAKATLLRVSGSDAAGYFRVWKVPKPRRKPGRARQEEGTRAPWRTPAAPRSSRRRRQPLRKAARKAREVWRRNARAKAKANARARRTRRARPRAKEPPCARAKEEAGATAADEGRGQAVKEDTTPRSGKDKRRSSKPREEKQEPKKPAQRTIQ
Protein: UDP-glucuronic acid decarboxylase 5 (EC 4.1.1.35) (UDP-XYL synthase 5) (UDP-glucuronate decarboxylase 5) (UGD) (UXS-5) (Q9SN95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- UDP-glucose 6-dehydrogenase 3
- UDP-D-apiose/UDP-D-xylose synthase 1
- UDP-glucose 6-dehydrogenase 4
- UDP-glucose 6-dehydrogenase 2
- Cellulose synthase-like protein D5
- UDP-sugar pyrophosphorylase
- UDP-D-apiose/UDP-D-xylose synthase 2
- UDP-glucose 6-dehydrogenase 1
- Putative UDP-glucose 6-dehydrogenase
- UDP-glucuronate 4-epimerase 1
Sequence:
MASSDKQTSPKPPPSPSPLRNSKFCQSNMRILISGGAGFIGSHLVDKLMENEKNEVIVADNYFTGSKDNLKKWIGHPRFELIRHDVTEPLLIEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGARILLTSTSEVYGDPLIHPQPESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNTYGPRMNIDDGRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVDGLMRLMEGDDTGPINIGNPGEFTMVELAETVKELINPSIEIKMVENTPDDPRQRKPDITKAKEVLGWEPKVKLREGLPLMEEDFRLRLGVHKN
Protein: Subtilisin-like protease SBT3.13 (EC 3.4.21.-) (Subtilase subfamily 3 member 13) (AtSBT3.13) (Q8GUK4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q84WS0}.
Interaction partners:
- Prolyl carboxypeptidase like protein
- Serine carboxypeptidase-like 26
- Serine carboxypeptidase-like 34
- Serine carboxypeptidase-like 42
- Uncharacterized protein
- Proteasome subunit alpha type-5-B
- Alpha/beta-Hydrolases superfamily protein
- Cysteine protease-like protein
Sequence:
MNNSLQSSKLVLLLAIALVLFLNTELDFLTAAGALDSDSKVYIVYLGEREHDDPELVTASHHQMLESLLQSKEDAQNSLIYSYQHGFSGFAALLTSSQAKKISEHPEVIHVIPNRIRKLKTTRAWDHLGLSPIPTSFSSLSSVKGLLHDTNLGSEAIIGVIDSGIWPESKAVNDQGLGPIPKRWRGKCEPGEQFNATIHCNNKLIGARYYLNGVVAAIGGKFNRTIIQDFQSTRDANGHGTHTATIAGGSFVPNVSYFGLAQGLVRGGAPRARIASYKACWNVMRDEGGGTDGRCTSADMWKAFDDAIHDGVDVLSVSIGGGIPEDSEVDKLDYIAAFHAVAKGITVVAAAGNEGPGAHTVDNVAPWLLTVAATTLDRSFPTKITLGNNQTLFAESLFTGPEISTGLAFLDSDSDDTVDVKGKTVLVFDSATPIAGKGVAAVILAQKPDDLLSRCNGVPCIFPDYEFGTEILKYIRTTRSPTVRITAATTLTGQPATTKVAAFSCRGPNSVSPAILKPDIAAPGVSILAAISPLNPEEQNGFGLLSGTSMSTPVVSGIIALLKSLHPKWSPAAVRSALVTTAWRTSPSGEPIFAEGSNKKLADPFDYGGGLVNPEKAAKPGLVYDMGIVDYIKYMCSAGYNDSSISRVLGKKTNCPIPKPSMLDINLPSITIPNLEKEVTLTRTVTNVGPIKSVYRAVIESPLGITLTVNPTTLVFKSAAKRVLTFSVKAKTSHKVNTGYFFGSLTWSDGVHDVIIPVSVKTTISM
Protein: Histone-binding protein RBBP7 (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Q71UF4)
Organism: Rattus norvegicus (Rat)
Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q16576}.
Interaction partners:
- SUZ12 polycomb repressive complex 2 subunit
- Polycomb protein EED
- [histone H3]-lysine
- Histone deacetylase 2
- Histone deacetylase 1
- Zinc finger protein AEBP2
- Histone-lysine N-methyltransferase EZH2
- Histone acetyltransferase type B catalytic subunit
- DNA helicase
- Chromodomain-helicase-DNA-binding protein 4
Sequence:
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS
Protein: Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.141) (Heme O synthase) (Q12887)
Organism: Homo sapiens (Human)
Function: Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein.
Interaction partners:
- Heme A synthase COX15
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase assembly protein COX11
- Surfeit locus protein 1
- Protein SCO1 homolog
- Holocytochrome c-type synthase
- Protein SCO2 homolog
- Ferrochelatase, mitochondrial
Sequence:
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS