wanglab/gogpt-training-data huggingface dataset:
Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (P0A6T1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00473, ECO:0000269|PubMed:4344919}.
Interaction partners:
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase isozyme 1
- Enolase
- Phosphoglucomutase
- Glucose-6-phosphate 1-dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase A
- Transketolase 1
- Pyruvate kinase II
- Pyruvate kinase I
- Phosphoglycerate kinase
Sequence:
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
Protein: Keratin, type II cytoskeletal 3 (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) (Q29426)
Organism: Oryctolagus cuniculus (Rabbit)
Interaction partners:
- Keratocan
- GCF C-terminal domain-containing protein
Sequence:
MNRQVCKTSGGGSLSFSGRSAVVSGSGGGGSSSRMSCVARSVAAGGGASGFRGGAGGFGSRSLYNLGGHKSISMSVAAGGSRAGGFGGGRSICGSGFGGGLGGGLGGGLGSGFGGGFGGGFGGAGAFGGAGGFGGAGGFGGPGGFGGPGGFPGGIQEVTVNQSLLQPLNVEIDPQIGQVRAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQRQGPNSVTGTNNLEPLFENRINYLRSYLDSIVGERGRLDSELRSMQDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKVDSLMDEINFLRTLYDAELSQMQSHVSDMSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSRAEAEAWYQTKLGELQTTAGRHGDDLRSTKNEIAEINRMIQRLRNEIENVKKQNASLQTAIAEAEQRGELALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEESRMSGECQSAVSISVVNSSSTTSAAAGGYGGGYGGGYGGGFGVGGGAGSGFGRGGGSGFGGGSGLGGGSGFGGGSGLGGGSGLGGGSIGFSVGSSGFGSGSGGRIGVSGGGFSSGSSSRGSSVKFSQSSQRYSR
Protein: Vacuolar protein sorting-associated protein 41 homolog (Q19954)
Organism: Caenorhabditis elegans
Function: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. May mediate the tethering of autophagosomes with lysosomes. Has a role in the negative regulation of apoptosis. Required for uptake of exogenous dsRNA which is used in experimental RNA silencing.
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:P49754}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49754}. Late endosome membrane {ECO:0000250|UniProtKB:P49754}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49754}. Early endosome membrane {ECO:0000250|UniProtKB:P49754}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49754}. Lysosome membrane {ECO:0000250|UniProtKB:P49754}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49754}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P49754}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:P49754}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49754}.
Interaction partners:
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 33A
- Ras-related protein Rab-7a
- t-SNARE coiled-coil homology domain-containing protein
- Vacuolar fusion protein CCZ1 homolog
- YKT6
- V-SNARE coiled-coil homology domain-containing protein
Sequence:
MDETHENEASDSFDPVFENSYHDDVTFNTEDDDEPPLEPRFKYERLKGEETLPFMKTATFTSIDLHDKFIAIGTATGLIYILDHHGYGNFDSVPPLKPHRCAVSKVKFDETGSYVLSCANDSKIVVSGVGNDKLCCTINIQVMPKSIYFSPDFIRQQSGHCFIMGERNLVLYEKRMFQYKASSLYSGSERDGFIHCCSWNENLIAFTNDTGTRVYERGAERIITSVQPSHDVDRVRSSRSPPKHTWMPENNLVIGWADTVTILKIRDDDGVKKGEVHHIFHVSMFICGISYIPESGIDNMELFLVGLQLEGEDFDDCASVISTVTTLTALESSACTILKTSVIRPLGLKEFELQSEDMIESVKLSNHTLPYMIHGLGIPYLATYFILTTKHIIMAVPYGPEDGIRWRLKYKLYDEALDMAKHNADLLSKTDLSPKKVGRMIIEGYLTGKRARAAASRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTPTLDPECYQKVLIACLFNNVKQFRKLVQTWSPDLYMTSFIIDRTQWRIQQISKSGNLADVDETERVLMDALAHLYLYERKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSERALRLLLDNADSVEPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNKARKLCSDKGYIEETIYLLAKSGNHYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVAEFPAHFSQLIIEASNCLDPLLIMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADESVSVNIVSRCSLCAQIIINSNQETTKKFSDIKVFKCGHIFHLACSTSEMERRQSIEEGLCIACSDQIELINV
Protein: Homeodomain-like superfamily protein (T7M13.16 protein) (Q9SG82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Agamous-like MADS-box protein AGL18
- Transcription factor bHLH101
- Two-component response regulator ARR9
- Transcription factor ORG2
Sequence:
MREDDSDWFARWEEELPSPEELMPISQSLISPDLALAFDIRTPNHGNGNSNQPHHHHHHQTTPPTPSQLQLPSSQANSSAEFAADSADLGSGGAAGDEPARTLKRPRLVWTPQLHKRFVDAVAHLGIKNAVPKTIMQLMSVDGLTRENVASHLQKYRLYLKRMQGLSSGGGAGSDPATDRLFASSPVPAHFLHPNRVPSSDHFMPSFVPIATLQQQQQMAAAAAAAAAANPHLQPPQFHRQIAAAHFGSPTNGGFSSPTSNGQFGSPTSNGFGSPTTNGKFDPSFLAVRQTQQQPIQRMSTPSLHSPVSNYVEDLESANANGGRTVLTLFPTRDD
Protein: Tubulin beta-2B chain (Q9CWF2)
Organism: Mus musculus (Mouse)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BVA1}.
Interaction partners:
- Tubulin alpha-1A chain
- Tubulin alpha-1B chain
- Microtubule-associated protein
- Kinesin-like protein KIF20A
- Tubulin alpha-1C chain
- Tubulin alpha-8 chain
- Tubulin alpha-4A chain
- Tubulin alpha chain-like 3
- Tubulin alpha-3 chain
- Gap junction alpha-1 protein
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
Protein: Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1) (Q8C1W1)
Organism: Mus musculus (Mouse)
Function: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7L8A9}. Secreted {ECO:0000250|UniProtKB:Q7L8A9}. Note=Mainly localizes in the cytoplasm. Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion. {ECO:0000250|UniProtKB:Q7L8A9}.
Interaction partners:
- Small vasohibin-binding protein
Sequence:
MPGGKKVVPSGSSSASPNAAATTTAAAAAAAAAPHSGTKRLETTEGASAQRDEEPEEEGEEDLRDGGVPFFINRGGLPVDEATWERMWKHVAKIHPDGEKVALRIRGATDLPKIPIPSVPTFQPTTPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPTLERFPISFKTYFSGNYFRHIVLGVNFGGRYGALGMSRREDLMYKPPAFRTLSELVLDYEAAYGRCWHVLKKVKLGQCVSHDPHSVEQIEWKHSVLDVERLGREDFRKELERHARDMRLKIGKGTGPPSPTKDRKKDVSSPQRAQSSPHRRNSRSERRPSGEKKPAEPKAMPDLSGYQIRV
Protein: DNA-binding protein RFX2 (Regulatory factor X 2) (P48378)
Organism: Homo sapiens (Human)
Function: Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:B2GV50, ECO:0000255|PROSITE-ProRule:PRU00858}. Cytoplasm {ECO:0000250|UniProtKB:B2GV50}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm. {ECO:0000250|UniProtKB:B2GV50}.
Interaction partners:
- Forkhead box protein J1
- Intraflagellar transport protein 88 homolog
- Serine/threonine-protein kinase ATR
- Large ribosomal subunit protein eL30
Sequence:
MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI
Protein: Large ribosomal subunit protein eL27A (60S ribosomal protein L27-A) (O14388)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL22
Sequence:
MVKILKPGKVALITRGRFAGKKVVILQAIDQGSKSHPFGHAVVAGVERYPLKVTKSMGAKRIARRSRVKPFIKVVNYNHLMPTRYALELDNLKGLITADTFKEPTQRSAARKTVKKTFEEKYQSGKSAWFFTPLRF
Protein: Small ribosomal subunit protein uS10 (30S ribosomal protein S10) (P9WH67)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the binding of tRNA to the ribosomes.
Interaction partners:
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein bL35
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein bL36
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL5
Sequence:
MAGQKIRIRLKAYDHEAIDASARKIVETVVRTGASVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDALMRIDLPASVDVNIQ
Protein: Protein kinase domain-containing protein (Q93637)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MMETRNASDSLMDQVFSAVTLPAVGQTTTIMEHHQESHTVFHQESHHVESHHEHMEFSSSGVIVGNVVGHDAVIQRRPTVDTEDQRSEVSAMSKATSVSVHSSVSQKSAQHYDLPPIPQYDMPPIVVGEAVVGKAPSVASSRSGSHHSVASHHSHHSQHSHHSALTHDSESTISEGTLVNEPIVVGAHVASEAPTPLAVGQSFEHDAVIEQFKNLHGRDQSVVSSIVPASVHIQSDSEDSIAPSKLTHSIAVGGVVDSHNGVNVLHRSHEVEFVDFAAPAYYQPPSVVGAFDAHSEDSFGFEKVEYVDTHEDHHHKLEEQVPQVVHEHVIEQHYEPYQIVHENHNVLSVDFGEDQHSITHHDHDHHHHHHESHVTHTFTSNVKQSRSNTASTYQSRQMLAHNVGPKITEELRPAAVLEEEEVEVRPPVMAYVAPIPVKPPRTHEESHIYNAYETEIHQQKDIVKSTTVVLEDVRSGSEGVSSLRRKFEHGAPPPLSPVFEMKKHEHHKHLDQHHHHKHQDVVVEQTQFQKVSEHVQLGGSRKSTIQSGHHHHHHHDHENRNDVPSRPSSVANYVKHQPHSRTSTVSTVRGAPVQRVNPTVQQHVIYNPYGDHQSVRVVKNVREFVNVFGATHVVPPPTPLAGVPRLSQRSPISHETFQPHDECNSVKSSRKNTLVSVGKGIQINDAPRKSTCSSVASSRSSSVSTVSAPILVGGNIAVPTPRSRNATLTQENVHEHDQYDDLIHVADMRKLFENYGPAHLPEYASNPSAYIH
Protein: Ankyrin 2 (A0A5F9ZHQ3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEDNNE
Protein: Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Q4G3H4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.
Interaction partners:
- Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
- TNF receptor-associated factor 6
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like-binding protein 3)
- Nuclear factor NF-kappa-B p105 subunit
- Interleukin-1 receptor-associated kinase 4.
- Interleukin-1 receptor-associated kinase 1
- Mitogen-activated protein kinase kinase kinase 7.
- Receptor
- Mitogen-activated protein kinase kinase kinase 14
Sequence:
MEKPPFRQNQVCGSWVMKERLGTGGFGHVYLYQNQETSEKIAVKLCRLELNSKNKDRWSRGIQIMKKLKHLNVVTAKDVPEEMMHIALNDLPLLAMEYCSKGDLRKLLSKPENCCGLKESEVLSLLNDVGSGIQYLHENKIIHRDLKPENIVLQEINGKLVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELFEGKSYTVTVDFWSFGTMIFECCCGFRPFLHNLQPVQWTSKVRNKGPKDIMAVEDMNGEVRFSTHLPYPNNLSRTLLEPLEGLLQLMLKWDPVQRGLGLNTDSKQPQCFVLLDQILSMKVVHILNMTTTQVHSFLLSPDEGLHSLQQRIENETKIELLNQDLLQETGVMSDPRKPAAQCVLDGVRGWDSYIVYLFDKSLTKYMGPLTARTLPESVNFIVRETKTQLPLSTLKKVWGEAVSYICGLREDYSRLFQGQRAAMLSLLRFNTNLTRYKNMMFSFSQQLKAKLDFFKTSIQYDLEKYSDQMQYGISSEKMLKAWHENEERAAAFAQVAEIGHLDEEIMALHSEIVELQRSPYARRQGDVMEQLQEKAIELYKQLKAKCKMPDPQHGYSDSSEMVKVIVQTVQNQDRVLRDLYAHLSKILLSKQKIIDLFPKIERTLECIKEADTTVMQMQIKRQREFWHLLKIACAQNTTRSSVSQSGEMPSSLSTWNQTQAQCSSRLPMSLQVPHEGDSVNHLLEENQRYLTQLTSLLQETTEEKSESIMAQDWSWTKYESLVAKSPRL
Protein: Mitogen-activated protein kinase mpkA (MAP kinase mpkA) (EC 2.7.11.24) (Q4WQR3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Mitogen-activated protein kinase; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator. The CWI signaling pathway regulates cell wall integrity and pyomelanin formation. CWI controls also oxidative stress response, gliotoxin production, iron adaptation and asexual development. Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection. MpkA positively modulates the expression of fumiquinazoline cluster during conidiogenesis and directly phosphorylates fmqC, and perhaps also fmqA.
Interaction partners:
- Mitogen-activated protein kinase kinae mkk2
- protein-tyrosine-phosphatase
- Transcription factor rlmA
- protein-tyrosine-phosphatase
- non-specific serine/threonine protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- Paf1-domain-containing protein
- Mitogen-activated protein kinase kinae kinase bck1
- Rho GTPase Rho1
Sequence:
MSDLQGRKVFKVFNQDFIVDERYNVTKELGQGAYGIVCAATNVHTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPNEETLSRIGSPRAQEYVRNLPFMPKIPFQRLFPNANPDALDLLDRMLAFDPASRISVEEALEHPYLHIWHDASDEPTCPTTFDFHFEVVDDVQEMRKMIYDEVVRFRNLVRQQSQAQAAAAAQQQQQQIAQQTNVPIPDHQQGGWKQEEPKPQEVHAAGGHVNDLESSLQRGMDVQ
Protein: Enhancer of mRNA-decapping protein 4 C-terminal domain-containing protein (Q54J96)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Small ribosomal subunit protein eS30
- Probable ATP-dependent RNA helicase ddx6
- mRNA-decapping enzyme 2
- mRNA-decapping enzyme-like protein
Sequence:
MNNRKLFMSHEELEKQQEQELQTQHQQQEENNNNSVLRFFQNLSGSMGSIPTQDPLQQQQQQQQQPPLPQQPNILSFLTGEMRSASPTISPSTSSNNVNINLHSSDKSIKNSIGNLNNKNSAGLHLGLNLYGKNININSKKSLGSKLEVESQTVTRVQPNRPSSNLIGNLISVNKYFISYIIKGEKVRILDKSSATKILLKEFPDVIDIQFHSENVNILSCCSMSDGCIYIYEIVNNGESINAKLLSKIKQQPQPQPQPQPHGSSSSSSSSSYYTTVKWHPTKNDTLLTCTNDSKLVYAFNINQPDTPLFILDPTTGNIPTGLCWFVQESPFNASGNVFEKSSILIANGDICIFNQQQQQQPNIYQLESTYSSINGSDGNNLDFLFVNHINFDTIVGVTRQSEIYLFNRQFSVIQKITFSNNLFSICSLLSIKDSFLFISDSNSSKAYIIHINSGKKDKSNDIIGDGSDDKDAINSLDGDNNNNINSNNNNNNNNEDNGGDEYPHFDYINECDFKKPIISFCFQSTPIINKSTSTNSLSSSTQSQQTYQHQQEKTIFSACTIQSHSVLLHSISLDTYYAENDQYSVNSLENDVVEQSGLYLDSLNSINGNNNNNNNNNNNNNSSNVGGNKNNGVLSPTSSTNATIGSEDDDINKIILLTPKSFTPSSPPPLSLPEPDLSSSPTSDDPIFGNVVSGKGVVNNNTTTTTSEKPKKEPSAARNLKKKTKSKENESNSTTTAAAATNTSGNNSTPSSSSSSPNGTNSTTPSTTVLSPPLLVNTTDDQSGSTSPASIKKVKPKTSTTKVTSSSSNESLNTLDTKEKEKEKEKEKTPTKLIKSTTTTTTTTSTTTTPSATTPTTTTPTKKTPSFVAPQLVIPLTNPASKLTPSKSLSSTNVNSVPTSSTSQSSSTTAPAPITTTTMTTATNTSPSLSPPTTANSTSTTSNIPSSFFFSPTETNQDHINTNAPLPVLPPPPLSPPQQQQQTSSPTTTTAATTTSNSNSQPIQQSNYTSNNIQQLFMEMENNLFNRLERSMANQFAQHEKERIEREAMEKERHEKLLTIVHQSITTMMKSNLEKIVKKEIAATFVNLEKTLPTTVEQTIGKIAQDQLKKLSVKTDTLLKSSSEAIVSNVKQLICSDIFEGLLKNQMETIFISYFQSILIPGFEKSCQSMFKHLSYTFENGFNQAIQHQTLSSQGQHLALEKILNEGNTVIKQCTTQLVEQQDQLLKEFKKQQQQQNQQQQQNHQQQNQQQHQQQQNQQQQQQQQMSQMPPQFQPLHHGPTGFYPFPPPPHSPLNNQQQPQTPPQQQQQLQQSQPQPPPQQQQQQQQQQQSQPQQQTQQQQQQLINQKLSAYPQLKALVETSYIDAFNFALNASNLQMVVSLCSCLDPYTVFSSNKFPQTIILSLIQQLSINLYTDTELKLKWIKECLFVVDNSKADVTKKILNVLKNKLDEHQNSNPNSNSHLLQSIKYIIKDI
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q57XI7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MRESQKKQQQTLILLAATTLLNVTAVALAQPNKVCTTPCGCKSRVIKRLEVYTTQFERALGQHQANLLDFSKLILAAVAADNQLKRKAAAALAPAAAILARCTDQLNAAAPPLTAAAYQAGYTAATYAAQHALTTMAGTLKIEPTGGKTLKAETITTKTLGSIPPAMCPTEDQTETGVKITTESEKDEPKLATIKLHSNAQAKCTATGANSCHDNALADSGNLEIQLTYAMGQKKTPWTWNSNTNADFQTTHSAEINLLRGNESDLDSKLTTLRTAHALDSCRKAIAEYSALSSDPNWALFNAKALLDNFESEKPSDISSDRLEQATNKAYGPDGTNYKNNVWHKIEQTQVPTVQHEQLKLQPIKSLSSTDEIGAALARVFINQQKKETQTHQKQGQKDDDTKENECSNKNGDKCKGDCVLDGDICKPKKKGEDENKEKDGKTASTCAGKDEKTCGTTQGCSWENNACKDFSILLTKQFALSMVSAAFVAFLF
Protein: Sorcin (Q6P069)
Organism: Mus musculus (Mouse)
Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12824171}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:12824171}; Peripheral membrane protein {ECO:0000269|PubMed:12824171}; Cytoplasmic side {ECO:0000269|PubMed:12824171}. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Interaction partners:
- Ryanodine receptor 2
- Presenilin-2
- Triadin
- Annexin A7
- Calmodulin-1
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Calmodulin-4
- Calmodulin 5
Sequence:
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV
Protein: Doublesex- and mab-3-related transcription factor 1 (Q9QZ59)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070, ECO:0000269|PubMed:11040213}.
Interaction partners:
- Transcription factor SOX-9
- Transcription factor GATA-4
- Muellerian-inhibiting factor
- Forkhead box protein L2
- Aromatase
- Stimulated by retinoic acid gene 8 protein
- Nuclear receptor subfamily 0 group B member 1
- Spermatid nuclear transition protein 1
- Steroidogenic factor 1
- Deleted in azoospermia-like
Sequence:
MPNDDTFGKPSTPTEVPHAPGAPPQGKAGGYSKAAGAMAGAAGGSGAGGSGGASGSGPSGLGSGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENNASNPCLMAENSSSAQPPPASTPTPAASEGRMVIQDIPAVTSRGHMENTSDLVSDPAYYSSFYQPSLFPYYNNLYNYPQYSMALSAESSSGEVGNSLGGSPVKNSLRSLPAPYVPAQTGNQWQMKTSESRHPVSSQYRMHSYYGPPSYLGQSMSQIFTFEEGPSYSEAKASVFSPPSSQDSGLVSLSSSSPMSNESSKGVLECESASSEPSSYAVNQVLEEDEDE