wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox-leucine zipper protein HDG3 (HD-ZIP protein HDG3) (Homeodomain GLABRA 2-like protein 3) (Homeodomain transcription factor HDG3) (Protein HOMEODOMAIN GLABROUS 3) (Protein UPCURVED LEAF 1) (Q9ZV65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor (By similarity). Seems to promote cell differentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|Ref.1}.
Interaction partners:
- Homeodomain-like superfamily protein
- Insulin-like growth factor binding protein
- MADS-box transcription factor PHERES 1
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7
- At2g13960
- Alpha-L-fucosidase 3
- Transcription factor MYB3R-2
- MADS-box transcription factor PHERES 2
- Maternally expressed PAB C-terminal protein
Sequence:
MSQSNMVPVANNGDNNNDNENNNNNNNNGGTDNTNAGNDSGDQDFDSGNTSSGNHGEGLGNNQAPRHKKKKYNRHTQLQISEMEAFFRECPHPDDKQRYDLSAQLGLDPVQIKFWFQNKRTQNKNQQERFENSELRNLNNHLRSENQRLREAIHQALCPKCGGQTAIGEMTFEEHHLRILNARLTEEIKQLSVTAEKISRLTGIPVRSHPRVSPPNPPPNFEFGMGSKGNVGNHSRETTGPADANTKPIIMELAFGAMEELLVMAQVAEPLWMGGFNGTSLALNLDEYEKTFRTGLGPRLGGFRTEASRETALVAMCPTGIVEMLMQENLWSTMFAGIVGRARTHEQIMADAAGNFNGNLQIMSAEYQVLSPLVTTRESYFVRYCKQQGEGLWAVVDISIDHLLPNINLKCRRRPSGCLIQEMHSGYSKVTWVEHVEVDDAGSYSIFEKLICTGQAFAANRWVGTLVRQCERISSILSTDFQSVDSGDHITLTNHGKMSMLKIAERIARTFFAGMTNATGSTIFSGVEGEDIRVMTMKSVNDPGKPPGVIICAATSFWLPAPPNTVFDFLREATHRHNWDVLCNGEMMHKIAEITNGIDKRNCASLLRHGHTSKSKMMIVQETSTDPTASFVLYAPVDMTSMDITLHGGGDPDFVVILPSGFAIFPDGTGKPGGKEGGSLLTISFQMLVESGPEARLSVSSVATTENLIRTTVRRIKDLFPCQTA
Protein: Insulin receptor substrate 1-A (IRS1-A) (xIRS-1-A) (XIRS-L) (Q91615)
Organism: Xenopus laevis (African clawed frog)
Function: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Interaction partners:
Sequence:
MNIRRCGHSENFFFIEVGRSAVTGAGEFWMQVDDSVVAQNMHETILEAMKALSDEFRPRSKSQSSSNCSNPISVPLRRHHLNHPPPSQVGLNRRARTESATATSPAGGAAKHGSSSFRVRASSDGEGTMSRPASMEGSPVSPSASRTQSHRHRGSSRLHPPLNHSRSIPMPATRCSPSATSPVSLSSSSTSGHGSTSDCMCPRRSSASISGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSMGHTPPAREEELNNYICMGKSSSHLQRGPQQRYQPSRGEELTDFDKVFRKRTHSSGTSPPTVSHQKTPSQSSIEEYTEMMPTHPVRLTSFRHSAFVPTYSYPEECLDLHLEGSRANHKDDGYMPMSPGVAPVSTKTNDYMPMSPKSVSAPQQIINPRWHSAVDSNGYMMMSPSGSCSPDNTNYSKIWTNGTNPKLSIDSIEGKLPCSDYINMSPASGSTTSTPPDSYLNSVEESTKPVYSYFSLPRSFKHVHRKSEDGNLRISANSGHNLYTEDSSSSSTSSDSLGGQDPQQPRKGEGCIQGKRLTRPTRLSLENSSKASTLPRVREPALPPEPKSPGEYVNIEFNDKVFSGGLVPSMCSLPFVQSRVVPQRENLSEYMNMDLGVWRAKTSYASTSSYEPPNKPVNSVCPTETCSSSRPPIRGKPISRDYMSMQLGSLCPDYSQVPPTRLSAKSITLSSSKSNYAEMSSGRVSDNIPAIAPASNSSLSEASRSSLLGQGSGPSAFTRVSLSPNRNPSAKVIRAGDPQGRRRHSSETFSSTPTTARVTTGPVSGEDVKRHSSASFENVWLRPGEIARRDSLQPSDHTHNGLNYIDLDLAKDLSSLDHCNSHQSGVSHPSDDLSPYASITFHKLEEHRSQAETEE
Protein: Nitrate/nitrite transporter (G5EB18)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU366033}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU366033}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Nitrate reductase
- Nitrite reductase [NAD
- Nitrate reductase
- Nitrate transporter
- Uncharacterized protein
- Oxidoreductase 2-nitropropane dioxygenase family, putative
- Oxidoreductase, 2-nitropropane dioxygenase family, putative
Sequence:
MKPTQVLRLAVAAPDVNPQTRKARSIPVLNPFDLYGRVFFFSWIGFLVAFLSWYAFPPLLSVTIKKDLHMSQDDVANSNIVALLGTFVMRFIAGPLCDRFGPRLVFVGLLICGAVPTAMAGLVTTPQGLIALRFFVGILGATFVPCQVWCTGFFDKNIVGTANSLAGGFGNAGGGITYFVMPAIYDSFVHDRGLTPHKAWRVSYIVPFIIIVSIALAMLFTCPDTPTGKWADREKTSGQSIVDLSSTPNASSANSINISSDEKKAVHPEVTDSEAQVHVRAGQIESSDAVIEAPTIKRYLSIALDPSALAVAVPYACSFGAELAINSILGAYYLLNFPLLGQTQSGRWASMFGLVNVVFRPMGGFIADLIYARTNSVWAKKMWLVVLGLAMSGMAILIGFLDPHRESVMFGLVVLMAFFIAASNGANFAIVPHVHPSANGIVSGIVGGMGNFGGIIFAIVFRYNGTQYHRSLWIIGFIILGCTLFFSWVRPVPKQNH
Protein: ComB, accessory factor for ComA (Q8DW04)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- ABC transporter, ATP-binding protein ComA
- Uncharacterized protein
- ABC transporter, ATP-binding protein
- ABC transporter, ATP-binding protein
- ABC transporter, ATP-binding and permease protein
- ATP-binding protein
Sequence:
MDPKFLQSAEFYRRRYHNFATLLIVPLVCLIIFLVIFLCFAKKEITVISTGEVAPTKVVDVIQSYSDSSIIKNNLDNNAAVEKGDVLIEYSENASPNRQTEQKNIIKERQKREEKEKKKHQKSKKKKKSKSKKASKDKKKKSKDKESSSDDENETKKVSIFASEDGIIHTNPKYDGANIIPKQTEIAQIYPDIQKTRKVLITYYASSDDVVSMKKGQTARLSLEKKGNDKVVIEGKINNVASSATTTKKGNLFKVTAKVKVSKKNSKLIKYGMTGKTVTVIDKKTYFDYFKDKLLHKMDN
Protein: Nkx2-8 protein (O13005)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MLPTPFSVEDILSLEQSSAPGAPRGPPQPFRGGGTAVGQCLLSQPLQADQQQTDPCHHPKQPQRRKPRVLFSQTQVLELERRFKQQKYLSALEREHLANVLQLTSTQVKIWFQNRRYKCKRQRQDRSLEMATYPLPPRRVAVPVLVRDGKPCFEGSQPHLAPYGITVSPYSYSTYSVPTGVSYGVGYTGVLTP
Protein: Transmembrane protein 107 (H2L2K0)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- Translocating chain-associated membrane protein
- MecKel-Gruber Syndrome
- Protein XRP2
- TMEM
- Transmembrane protein 231
- Transmembrane protein 237 homolog
Sequence:
MFTKTDTCTKYFQCLMGHFALSTITIFSQASHLEASVSGGASISEEARIGFTVCLVFTKLAILIEFASILVDLPSPSRSLYSTLSHTIASIFFLIFIYDSHPPAHFWLLFAFLSLPPCVLAVSASIGGFRRKEWQK
Protein: Serine/threonine kinase 38 (A0A8I6GKQ3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
SFLLSSQGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFSLYAWMEPIHTDSAFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPG
Protein: LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein (A0A1D8PCT7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MRSLSVARGVSYLVHFKVLQLLVAVIVVFNIYIAATNVFDKHISNHASKQLAVKLTQSDVSTILTTGTLNSNFKNNEQFQVNNGFKLPTFKTIPTHNKHKSPNKPKYLVPNVPYDELSFKDKILFKLNEVDFNKDKDWLKSQELTSHKVEVHVNEFTQEMWDNNPGLFFDPRFTLSVYLVEIKRQMCENAATRSSDEIVLPFSWTDWVDLTMLNDELVKPERQRISCEYLKATHDSSSKYPYYCINNEDIDGQELELMKLPSTNYVPGYAVRKSPTNRATNVVRMLEGKSHLLTYADIPTKLVFLNKQGGIYVTEVSTKQRITESGLFDGFVKSHYADSRIPETIILDPIKEFESLLKLKEPQKWNEVYDSRNFSYSITLTDYDIPEKDFNYSESEFLDDMTKFGDRLDSLHDLTTNELRFDKQEIANLRLNRNEMRYYESLQYAYARKNMQEPVYFRNARLITKIEENKQDSGWNYDWRFFNGALDYLQNDWTEEQLMIRRQIILERLLRNWTRFAIEGRFISWISQSSLSSWYWNGQLSSFSQKIEIQMPIKELLRLALTYNQTMVVEDVTEGFGKYFIDCSTFVHYRGSAKSGNHIDAKFIDVDTGLSVEIGGVAISHETAPKRYTNIVTEAQHNGQLRQVYNTRRPRFYTSDEISPLRKSMFAGTPVYVPNNISAILNQEYHKKLIPFNAYGYYFVTQLNLWIHHSKLKFLFEKFENTSLSLENGQTDATELCELVATIDEEQIVELLTRHDDILLEYYLSSDLGDLHKKELICLFEDVNKIDNARICDKTTKIGESKHRVELANDPEYRELVTSFTFQNFKRISLYDYDQLARSKAS
Protein: Senescence marker protein-30 (SMP-30) (Smp-30 protein) (Q9NDS6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSYKVEAVPDSYAALGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYKAKIEGEIFASFILPVENKPQEFAVGCGLRTVIVQWDGVSAVAKVTRTLFEVQPDLKENRLNDAKTDPNGRFYGGTMADSGDIFTQWKGELYSWQAGGQPNAIRSKVGISNGLAWDVKAKKFYFIDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKILLEIKIPTTQITSVAFGGPNLDILYVTTANKFDQPKPAGTTFQVTGLNAKGYAGVNLKI
Protein: Candida glabrata strain CBS138 chromosome D complete sequence (Q6FWA1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MSLLQPFTCTCYPLRLPAAQAGSGDEYVRRKQSLDCRTGAAVTLTRSNIFVHGGLTIPLNLEKVTCAEIQNQVVLYFAKEKDCSAGFKDLKQWLSPEIFFLDLISRTWNRVDTTVESETMLGAGAGAGAGTATGTGMETDPAREAADVDVFANEQSLSSSVTLSVIEQESFRERLFHSMCYVDGNIFVFGGLVMSPQNGYEFTASNELWRLDLRTKQWSLVSRNPLIQRRFNHSMHVKNEHSDTRDTKIVIVGGLNNLDEPVHKVDIYNLTRGYWQSVPDSEFPIELETNIEGKPVDLATDSCFSILVENNEAKIPALAFYKPLSCRDHSVITSRSKKAKQVSGRSSVDTEMAVCDSDTGTKEQDEQDPNSQSPIVALPIVSGSKGIRMASHPLQPNDLLEAPLNLLNPTGDYFGYNIVIGGFCPTLLPSDFHCYIYDIPSGKWTRIGITCPDCEINTHRFWKLFVWDSHHQALVLGTKNDDGYLPSVQKFDHLLSFGLPIINIFNKGIHSVPSNKDAVMSVPDSKFGSSGVSDLESDLNRMSFASSQTSQFESYIRYIAPPYEMTSIRSVFPAYAMVLGKDALEIYGKPLSDFELVSSEGEAIGVPLYLLRKRWGRYFDLLLSQGYSKACTEYEASGNLSTLIKLTPFSSRTGSRDIHSSRLSSSSSLDNYFVKGIGAQHHHYSVSGPAGRKPPGSENIVDRTSRSSVDGHLMGSSPNPMSESVYLTHIDDVDDDDDDCVGPTSQAKNTNKMKSVSRTITSSTTSSTGGMVFRVPFQEKKPSSSVQDIAPDSQFFQTGSSSRRSSLLSSQTMGIQRSPKIEGKRRASHPIISSIMDKGQPVSTRSVGSTRSSLSYVSSSSERQSKSHLPGSRNSSVTGSPILGVLNVPLPPPCQTPTEPVPPPPVTKYPNITSKPRTNSMSEVFNTIKGSPLSSRRSSYSRKTSTSEVNSAIDRQLMEDRFKEADMAFAKQTPTKPVAGSKMPENIRSSTRNSVNNDWSRHSFASVSDSSESATVNGNIEMEPMLIPRTLYLPWSTATVHAFAEFFYTGQVNGKWMLSPVVLDLLVISKLYELPLLFNLISEVLYSIVGKKEEGMYITCKSLIDSFSRKVSTYFGNDKEKEVAYLESCEAYKILKKIKLCLERIDNGFFDLDLMRRHSMSRSSYNSSNGSTVEKKNSLDLSPRGSSNLPTMMGNGPRDSHVSIESLNYPMHMNIPSSRRSTGTFAHRTTKKSSLSKEIDPSFFNDTSSTLSLHDTAIVKDFNEKIAKADTITEKDYSSTSSSSSCDLDDESDQEKLRHLSETDFATILDTRDSKSHQLNTKEDINNFDFSLGLLSSFNDEKNKLRKVDVDEPIDPLAKISHNLDSPNRLYSKYSQGFGKMPKSGSQASNMGLLTLENLASPNALPPDDAVIKAIHQTTVLANEVRLMIRCGDCLQISKDLRRCKKIMNSELTKLEKTHNVSESRTSISASSSQTRLSDYQSSTNSGKITPTAGGSVTTMDPLVKSKLKQNLTGQELHPGIHFVETLHSPKSVADFESKETSSQPGVLNGLHTGLHSGFHAGLHTSPHAGLHSKPQHSHSATKIPKVSHKLGKATTSTSLKSESKSPSSTNLGKKEHNSSLGPLSFFGIRNK
Protein: Zinc finger protein 809 (G3X9G7)
Organism: Mus musculus (Mouse)
Function: Transcription factor specifically required to repress retrotransposons in embryonic stem cells. Recognizes and binds retroviral DNA sequences from a large subset of mammalian retroviruses and retroelements and repress their expression by recruiting a repressive complex containing TRIM28/KAP1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription intermediary factor 1-beta
- Histone-lysine N-methyltransferase SETDB1
Sequence:
MGLVSFEDVAVDFTLEEWQDLDAAQRTLYRDVMLETYSSLVFLDPCIAKPKLIFNLERGFGPWSLAEASSRSLPGVHNVSTLSDTSKKIPKTRLRQLRKTNQKTPSEDTIEAELKARQEVSKGTTSRHRRAPVKSLCRKSQRTKNQTSYNDGNLYECKDCEKVFCNNSTLIKHYRRTHNVYKPYECDECSKMYYWKSDLTSHQKTHRQRKRIYECSECGKAFFRKSHLNAHERTHSGEKPYECTECRKAFYYKSDLTRHKKTHLGEKPFKCEECKKAFSRKSKLAIHQKKHTGEKPYECTECKKAFSHQSQLTAHRIAHSSENPYECKECNKSFHWKCQLTAHQKRHTGVTYFQEVVFQQITVSDWTGNLSENGPHRPTWTWAYGIMDFVKAWSRCIIGGGL
Protein: ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9) (Q8NDG6)
Organism: Homo sapiens (Human)
Function: ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28536242}. Nucleus {ECO:0000250|UniProtKB:Q14BI7}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. {ECO:0000250|UniProtKB:Q14BI7}.
Interaction partners:
- Piwi-like protein 4
- Protein maelstrom homolog
- Piwi-like protein 2
- Piwi-like protein 1
- Tudor domain-containing protein 1
- RNA helicase Mov10l1
- Tudor and KH domain-containing protein
- Putative ATP-dependent RNA helicase TDRD12
- Tudor domain-containing protein 5
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
Sequence:
MLRKLTIEQINDWFTIGKTVTNVELLGAPPAFPAGAAREEVQRQDVAPGAGPAAQAPALAQAPARPAAAFERSLSQRSSEVEYINKYRQLEAQELDVCRSVQPTSGPGPRPSLAKLSSVTCIPGTTYKYPDLPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILDHYVQRSAYCSIVVTQPRKIGASSIARWISKERAWTLGGVVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAVPVQNKMNPAYIFEVEGKPHSVEEYYLNDLEHIHHSKLSPHLLEEPVITKDIYEVAVSLIQMFDDLDMKESGNKAWSGAQFVLERSSVLVFLPGLGEINYMHELLTSLVHKRLQVYPLHSSVALEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQRKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLGHVFGCLDECLIIAAALSLKNFFAMPFRQHLDGYRNKVNFSGSSKSDCIALVEAFKTWKACRQTGELRYPKDELNWGRLNYIQIKRIREVAELYEELKTRISQFNMHVDSRRPVMDQEYIYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIPPYGFLYYKQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEGKVQGMNVSKLRNTRVNVDFQKQTVDPMQVSFNTSDRSQTVTDLLLTIDVTEVVEVGHFWGYRIDENNSEILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADFDKQRYFRAQVLYVSGNSAEVFFVDYGNKSHVDLHLLMEIPCQFLELPFQALEFKICKMRPSAKSLVCGKHWSDGASQWFASLVSGCTLLVKVFSVVHSVLHVDVYQYSGVQDAINIRDVLIQQGYAELTEESYESKQSHEVLKGLFSKSVENMTDGSVPFPMKDDEKYLIRILLESFSTNKLGTPNCKAELHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDAPEDLHQRMLVAASLSINATGSTMLLRETSLMPHIPGLPALLSMLFAPVIELRIDQNGKYYTGVLCGLGWNPATGASILPEHDMELAFDVQFSVEDVVEVNILRAAINKLVCDGPNGCKCLGPERVAQLQDIARQKLLGLFCQSKPREKIVPKWHEKPYEWNQVDPKLVMEQADRESSRGKNTFLYQLHKLVVLGT
Protein: Suppressor of variegation 2-10, isoform K (A0A0B4JCQ7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPFPSLQECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSAVSAMNTMRKAK
Protein: ATP-binding protein Uup (EC 3.6.1.-) (P43672)
Organism: Escherichia coli (strain K12)
Function: Probably plays a role in ribosome assembly or function; overexpression suppresses cold-sensitive growth of a bipA deletion (Ref.10) (Probable). May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA at Holliday junctions. May be involved in the correct segregation of nucleoids. Has ATPase activity, binds DNA non-sequence specifically; the presence of DNA does not change the ATPase activity. Mutations in this gene cause an increase in RecA-independent precise excision of transposons and insertion elements, and also reduce bacteriophage Mu growth.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00848, ECO:0000269|PubMed:16407313, ECO:0000269|Ref.10}. Note=Associates with ribosomes. {ECO:0000255|HAMAP-Rule:MF_00848, ECO:0000269|Ref.10}.
Interaction partners:
- Ribosomal RNA large subunit methyltransferase K/L
- Putative DNA repair helicase RadD
Sequence:
MSLISMHGAWLSFSDAPLLDNAELHIEDNERVCLVGRNGAGKSTLMKILNREQGLDDGRIIYEQDLIVARLQQDPPRNVEGSVYDFVAEGIEEQAEYLKRYHDISRLVMNDPSEKNLNELAKVQEQLDHHNLWQLENRINEVLAQLGLDPNVALSSLSGGWLRKAALGRALVSNPRVLLLDEPTNHLDIETIDWLEGFLKTFNGTIIFISHDRSFIRNMATRIVDLDRGKLVTYPGNYDQYLLEKEEALRVEELQNAEFDRKLAQEEVWIRQGIKARRTRNEGRVRALKAMRRERGERREVMGTAKMQVEEASRSGKIVFEMEDVCYQVNGKQLVKDFSAQVLRGDKIALIGPNGCGKTTLLKLMLGQLQADSGRIHVGTKLEVAYFDQHRAELDPDKTVMDNLAEGKQEVMVNGKPRHVLGYLQDFLFHPKRAMTPVRALSGGERNRLLLARLFLKPSNLLILDEPTNDLDVETLELLEELIDSYQGTVLLVSHDRQFVDNTVTECWIFEGGGKIGRYVGGYHDARGQQEQYVALKQPAVKKTEEAAAAKAETVKRSSSKLSYKLQRELEQLPQLLEDLEAKLEALQTQVADASFFSQPHEQTQKVLADMAAAEQELEQAFERWEYLEALKNGG
Protein: Stanniocalcin (STC) (Corpuscles of Stannius protein) (CS) (Hypocalcin) (Teleocalcin) (Q08264)
Organism: Oncorhynchus kisutch (Coho salmon) (Salmo kisutch)
Function: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MLAKFGLCAVFLVLGTAATFDTDPEEASPRRARFSSNSPSDVARCLNGALAVGCGTFACLENSTCDTDGMHDICQLFFHTAATFNTQGKTFVKESLRCIANGVTSKVFQTIRRCGVFQRMISEVQEECYSRLDICGVARSNPEAIGEVVQVPAHFPNRYYSTLLQSLLACDEETVAVVRAGLVARLGPDMETLFQLLQNKHCPQGSNQGPNSAPAGWRWPMGSPPSFKIQPSMRGRDPTHLFARKRSVEALERVME
Protein: Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) (Q9Y6A1)
Organism: Homo sapiens (Human)
Function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14699049}; Multi-pass membrane protein {ECO:0000269|PubMed:14699049}.
Interaction partners:
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- Protein O-mannosyl-transferase 2
- Dystroglycan 1
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
- Ribitol-5-phosphate transferase FKTN
- Ribitol 5-phosphate transferase FKRP
- Xylosyl- and glucuronyltransferase LARGE1
- Ribitol-5-phosphate xylosyltransferase 1
- Protein O-mannose kinase
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Sequence:
MWGFLKRPVVVTADINLSLVALTGMGLLSRLWRLTYPRAVVFDEVYYGQYISFYMKQIFFLDDSGPPFGHMVLALGGYLGGFDGNFLWNRIGAEYSSNVPVWSLRLLPALAGALSVPMAYQIVLELHFSHCAAMGAALLMLIENALITQSRLMLLESVLIFFNLLAVLSYLKFFNCQKHSPFSLSWWFWLTLTGVACSCAVGIKYMGVFTYVLVLGVAAVHAWHLLGDQTLSNVGADVQCCMRPACMGQMQMSQGVCVFCHLLARAVALLVIPVVLYLLFFYVHLILVFRSGPHDQIMSSAFQASLEGGLARITQGQPLEVAFGSQVTLRNVFGKPVPCWLHSHQDTYPMIYENGRGSSHQQQVTCYPFKDVNNWWIVKDPRRHQLVVSSPPRPVRHGDMVQLVHGMTTRSLNTHDVAAPLSPHSQEVSCYIDYNISMPAQNLWRLEIVNRGSDTDVWKTILSEVRFVHVNTSAVLKLSGAHLPDWGYRQLEIVGEKLSRGYHGSTVWNVEEHRYGASQEQRERERELHSPAQVDVSRNLSFMARFSELQWRMLALRSDDSEHKYSSSPLEWVTLDTNIAYWLHPRTSAQIHLLGNIVIWVSGSLALAIYALLSLWYLLRRRRNVHDLPQDAWLRWVLAGALCAGGWAVNYLPFFLMEKTLFLYHYLPALTFQILLLPVVLQHISDHLCRSQLQRSIFSALVVAWYSSACHVSNTLRPLTYGDKSLSPHELKALRWKDSWDILIRKH
Protein: Tetratricopeptide repeat domain 39A (E9PQ33)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTALDLFLTNQFSEALSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLLQRAALTFLQGSSHGGAVRP
Protein: Hormone receptor 4 (dHR4) (Nuclear receptor subfamily 6 group A member 2) (Q9W539)
Organism: Drosophila melanogaster (Fruit fly)
Function: Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15935763}.
Interaction partners:
- Probable nuclear hormone receptor HR3
Sequence:
MTLSRGPYSELDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTSSPDLLAPMSPKLCDSGSAGASLGASLPLPLALPLPMALPLPMSLPLPLTAASSAVTVSLAAVVAAVAETGGAGAGGAGTAVTASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSSTSSSTSSASPTAGASSTATCPASSSSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAASTVMSPPPAEATRSSPATPEGGGPAGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRPTLTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQETKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERERERDRDREREREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLTLRKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVRVKKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAAILFRVKSEVHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKEVELESIQERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASIR
Protein: Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) (Q8NHW3)
Organism: Homo sapiens (Human)
Function: Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:12917329}.
Interaction partners:
- Pancreas/duodenum homeobox protein 1
- Insulin
- Neurogenic differentiation factor 1
- Neurogenin-3
- Solute carrier family 2, facilitated glucose transporter member 2
Sequence:
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGGGAGGGGGSSQAGGAPGPPSGGPGAVGGTSGKPALEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGPGFAGGGGADDMGAGHHHGAHHAAHHHHAAHHHHHHHHHHGGAGHGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGSAGGAGFPREPSPPQAGPGGAKGTADFFL
Protein: Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) (Q9JL06)
Organism: Mus musculus (Mouse)
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity).
Subcellular location: Cell surface {ECO:0000250}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. {ECO:0000250}.
Interaction partners:
- Lysophosphatidic acid receptor 4
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 5
- Lysophosphatidic acid receptor 6
- Guanine nucleotide-binding protein subunit alpha-12
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor 3
- Na
- Guanine nucleotide-binding protein subunit alpha-13
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Sequence:
MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVTLIVGVWAAALGLGLLPAHFWHCLCDLDSCSRMVPLFSRSYLAAWALSSLLVFLLMVAVYTRIFFYVRRRVERMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLDCKSCNVLAVEKYFLLLAEANSLVNAVVYSCRDAEMRRTFRRLLCCMCLRWSSHKSARYSASAQTGASTRIMLPENGRPLMDSTL