wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2) (Q498M5)
Organism: Rattus norvegicus (Rat)
Function: Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TEC5}.
Interaction partners:
Sequence:
MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAHKELRCPECRTLVFCSIEALPANLLLVRLLDGVRSGHNSWRGGSFRRPRILTLQDNRKAKSSPRSLQASPFRLGPTVRIHMDGVPRAKALCNYRGKNPGDLKFNKGDVILLQRQLDENWYQGEINGVSGFFPASSVEVIKQLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDDVITVISRVDENWAEGKLGDKVGIFPILFVEPNLSARHLLEKSKGHQLSRTKHLSLMSSPSRGKATNTSTLRKSPGSRRKGSGQFAMTTALNTLNRMVHSPEGHQMVEISTPVLISSTSPSMLTQHGDRADFPASSAGQVSTSHPAPASPGHSTAMVSVPSSQQHLSTNMFVALHTYSAQGPEELDLKKGEGIRVLGKNQDGWLRGVSLVTGRTGIFPSDYVIPVFSSTARKTSSFPDSRHPTVCTTWALSTSSVSSQGSFSEGDPRQSGPFRSVFVPTAVNPPRSTSGPGTSGQGSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPAMVIRPQKFQFYQPQGMTPSPTPIMVEIGSKSISTGEPALTCINRGGKTRTHSAGNSIIMEGKETPIKSEPPPKPPASAPPSILVKPENSKNGIEKQVKTVRFQNYSPPPTKHSASGPTSGKHEQPATLKGSQPEAVSSEGEMTILFAHRSGCHSGQQTDLRRKSAFSKTTPPVSTASVSQTLFPSK
Protein: U-box domain-containing protein 11 (EC 2.3.2.27) (Plant U-box protein 11) (RING-type E3 ubiquitin transferase PUB11) (Q8GUG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- Leucine-rich repeat protein 1
- SCY1-like protein 2 B
- SCY1-like protein 2 A
- ALA-interacting subunit 5
- ALA-interacting subunit 1
- Cleavage and polyadenylation specificity factor subunit 3-I
Sequence:
MAGGIVSPASLLDLIADIVEIPLNTGMFKKDCADLTRRVCLLTHLLEEIRDSTPIDSAASSSSENDWWSDLVVGLQAAKRLLSTARFQARDSSDGAAKRISFQFQCVTWKLEKALSNLPYDLYDISDEVGEQVELARSQLRRAMQRYGSLNSNKFSSALSEPMERDGFSNVIKIKAEEKLESVSETLHFGEEEEKQSSPPLRRSSSISLAYYLSKDADTDRLDKMVNKNTDESKKSDKLTIPVDFLCPVSLELMKDPVIVATGQTYERAYIQRWIDCGNLTCPKTQQKLENFTLTPNYVLRSLISRWCAEHNIEQPAGYINGRTKNSGDMSVIRALVQRLSSRSTEDRRNAVSEIRSLSKRSTDNRILIAEAGAIPVLVNLLTSEDVATQENAITCVLNLSIYENNKELIMFAGAVTSIVQVLRAGTMEARENAAATLFSLSLADENKIIIGGSGAIPALVDLLENGTPRGKKDAATALFNLCIYHGNKGRAVRAGIVTALVKMLSDSTRHRMVDEALTILSVLANNQDAKSAIVKANTLPALIGILQTDQTRNRENAAAILLSLCKRDTEKLITIGRLGAVVPLMDLSKNGTERGKRKAISLLELLRKACQ
Protein: Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) (O14910)
Organism: Homo sapiens (Human)
Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction {ECO:0000250|UniProtKB:Q8JZS0}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8JZS0}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0}.
Interaction partners:
- Protein PALS1
- Peripheral plasma membrane protein CASK
- Amyloid-beta A4 precursor protein-binding family A member 1
- Protein PALS2
- InaD-like protein
- MAGUK p55 subfamily member 2
- MAGUK p55 subfamily member 7
- Glutamate receptor ionotropic, NMDA 2B
- Kinesin-like protein KIF17
- Disks large homolog 1
Sequence:
MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
Protein: Periplasmic trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (Tre37A) (P13482)
Organism: Escherichia coli (strain K12)
Function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
Subcellular location: Periplasm.
Interaction partners:
- Trehalose-6-phosphate phosphatase
- Trehalose-6-phosphate hydrolase
- Cytoplasmic trehalase
- Trehalose-6-phosphate synthase
- Catalase HPII
Sequence:
MKSPAPSRPQKMALIPACIFLCFAALSVQAEETPVTPQPPDILLGPLFNDVQNAKLFPDQKTFADAVPNSDPLMILADYRMQQNQSGFDLRHFVNVNFTLPKEGEKYVPPEGQSLREHIDGLWPVLTRSTENTEKWDSLLPLPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFAHEIDTYGHIPNGNRSYYLSRSQPPFFALMVELLAQHEGDAALKQYLPQMQKEYAYWMDGVENLQAGQQEKRVVKLQDGTLLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLNTLRTTSIVPVDLNSLMFKMEKILARASKAAGDNAMANQYETLANARQKGIEKYLWNDQQGWYADYDLKSHKVRNQLTAAALFPLYVNAAAKDRANKMATATKTHLLQPGGLNTTSVKSGQQWDAPNGWAPLQWVATEGLQNYGQKEVAMDISWHFLTNVQHTYDREKKLVEKYDVSTTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPKEQPCDNVPATRPTVKSATTQPSTKEAQPTP
Protein: Forkhead box I1 (E0XEN6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV
Protein: PAR domain protein 1-beta (PAR-domain protein 1, isoform G) (Q9TW49)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDRERSSPTLIETGLKNLIGGRDGNYPLISGINGRKSPFLGFICKSNGKSTSNSKEIICPDDKYKEEGDIWNVEAQTAFLGPNLWDKTLPYDADLKVTQYADLDEFLSENNIPDGLPGTHLGHSSGLGHRSDSLGHAAGLSLGLGHITTKRERSPSPSDCISPDTLNPPSPAESTFSFASSGRDFDPRTRAFSDEELKPQPMIKKSRKQFVPDELKDDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKENATLHQEVEQLKQENMDLRARLSKFQDV
Protein: Elongin B (O44226)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Elongin-C
- Cullin-2
- Cullin-5
- Transcription elongation factor B polypeptide 3
- Ubiquitin-like protein NEDD8
- Protein Vhl
- RING-box protein 1A
- Suppressor of cytokine signaling at 16D, isoform B
- Suppressor of cytokine signaling at 36E, isoform D
- RING-box protein 2
Sequence:
MDVFLMIRRQKTTIFTDAKENTTVAELKRMIEGILKVQPVDQRLYNQDNDVMEDDSTLQDYGVTVSTAKAQAPAQLGLTFRNEVGDFETLDMTPYSAPPDLPEVMKNQEASNGQEQVA
Protein: tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG (Glucose-inhibited division protein A) (A0A0F6B945)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00129}.
Interaction partners:
Sequence:
MFYQDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVSRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRNNLDRSPMYAGVIEGIGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIHGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEMGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAESADEVNAHLTTPLSREASGEDLLRRPEMTYAQLTSLAAFAPALEDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
Protein: Myosin Ic, paralog b (E7F5R7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, stereocilium membrane {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MKYRGMAVGSDGIRVMMESALTARDRVGVQDFVLLENHTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDLEIYTKQHMERYRGVNFYEVSPHIYAVADNAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAVTCPASDHVQTVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSRVVHQSNGERNFHIFYQLIEGGEDDLLRRLGLERNAQQYQYLVKGNCPKVSSINDRNDWKTVRKALSVIGFTDDEVEELLNIIASVLHLGNVQYGGEDSGSAYITTDTQIKYLARLLGVDGTVLKEALTHKKIIAKGEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKNASVIGLLDIYGFEVFQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGDASDITFLEKLENTVGGHAHFLTHKLADGKTRKVMGREEFRLIHYAGEVNYNVKGFLDKNNDLLFRNLKQVMCMSENKILNQCFDREELSDKKRPETAATQFKNSLAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRRYETFLQRYKSLCPDTWPNWDGRQVDGVSTLVKHLGYKPEEYKLGRTKIFIRFPKTLFATEDALEVRKHSLATQLQSSWKGYSQKTKYQKMRHSAVWIQAWWRGILARRAAKRRREAADTIRRFIKGFIYRHQPRCPENEYFLDYVRYSFLMNLHRCQPKTVLDKSWPTPPPALVEASQHLRKLCMQNMVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYPQSVPKLFVNTRLNGEDINPKVLQALGNEKMKYAVPVIKYDRKGYKARNRQLLLMSDSAVIVEEGKLKQRIDYNSLKGISVSSLSDGMFVFHVASEDNKQKGDVVLQNEHVIETLTKVAICADKMDDININQGSIKFDVAQGKEGIIDFTAGSELLIVKAKNGHLSVTAPRLNSR
Protein: Homeobox-DDT domain protein RLT1 (Protein HOMEOBOX-1) (Protein RINGLET 1) (F4HY56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator required for the maintenance of the plant vegetative phase. In association with CHR11 or CHR17 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
Interaction partners:
- FHA domain-containing protein FHA2
- ISWI chromatin-remodeling complex ATPase CHR11
- Homeobox-DDT domain protein RLT2
- DDT domain-containing protein DDR4
- PHD-finger and DNA binding domain-containing protein
- WD-40 repeat-containing protein MSI3
- PHD finger family protein
- Zinc-finger domain of monoamine-oxidase A repressor R1 protein
- DDT domain-containing protein PTM
- DDT domain-containing protein
Sequence:
MEMGSDGEDQKIRSVVGDANLNNKKKKIDNNSSSKDGRVKPKRQMKTPFQLETLEKVYSEEKYPSEATRAELSEKLDLSDRQLQMWFCHRRLKDKKDGQSNKPVKSSVAAVQSASVNELPAAAGSVPEQDSRSDSGSESGCSPYSNSRRNFASGSSSSRAELDEYETMGKPSYESRLSTMVHRAIVCIEAQLGEPLRDDGPILGMEFDPLPPGAFGTPIAMQKHLLHPYESDLYERHDPRPRRSHAAARSFHEQQSLDDPSSFTPNMYERYSENHARGMDYEVARSRISSFMHANGPVPRSYVTPGHASRNCSTSQQDMPSPIESAHHGDRFLLEKDSSVLGTEDPYLLPDGVRKSSDVHRKGKINDGRLGRGSETRENHGPKDLEKLEIQRKKNEERMRKEMERNERERRKEEERLMRERIKEEERLQREQRREVERREKFLQRENERAEKKKQKDEIRREKDAIRRKLAIEKATARRIAKESMDLIEDEQLELMELAAISKGLPSVLQLDHDTLQNLEVYRDSLSTFPPKSLQLKMPFAISPWKDSDETVGNLLMVWRFLISFSDVLDLWPFTLDEFIQAFHDYDSRLLGEIHVTLLRSIIRDVEDVARTPFSGIGNNQYTTANPEGGHPQIVEGAYAWGFDIRSWKKHLNPLTWPEILRQLALSAGFGPKLKKKHSRLTNTGDKDEAKGCEDVISTIRNGTAAESAFASMREKGLLAPRKSRHRLTPGTVKFAAFHVLSLEGSKGLTVLELADKIQKSGLRDLTTSKTPEASISVALTRDVKLFERIAPSTYCVRAPYVKDPKDGEAILADARKKIRAFENGFTGPEDVNDLERDEDFEIDIDEDPEVDDLATLASASKSAVLGEANVLSGKGVDTMFCDVKADVKSELEKEFSSPPPSTMKSIVPQHSERHKNTVVGGVDAVIDESNQGQSWIQGLTEGDYCHLSVEERLNALVALVGIANEGNSIRTGLEDRMEAANALKKQMWAEAQLDNSCMRDVLKLDLQNLASSKTESTIGLPIIQSSTRERDSFDRDPSQLLDETKPLEDLSNDLHKSSAERALINQDANISQENYASKRSRSQLKSYIGHKAEEVYPYRSLPLGQDRRHNRYWHFAVSVSKSDPCSRLLFVELHDGKWLLIDSEEAFDILVASLDMRGIRESHLRIMLQKIEGSFKENACKDIKLARNPFLTEKSVVNHSPTDSVSPSSSAISGSNSDSMETSTSIRVDLGRNDTENKNLSKRFHDFQRWMWTETYSSLPSCARKYGKKRSELLATCDACVASYLSEYTFCSSCHQRLDVVDSSEILDSGLAVSPLPFGVRLLKPLLVFLEASVPDEALESFWTEDQRKKWGFRLNTSSSPGELLQVLTSLESAIKKESLSSNFMSAKELLGAANAEADDQGSVDVLPWIPKTVSAVALRLSELDASIIYVKPEKPEVIPEDENEQISLFPRDSPFKGKGPREQEDQDEVAPNPGNRNKKRARVSLGSGSNRKVKRKKAQSGLNKFVVGRRNVAVNSNLMAVELNHQVPGKGKRTVRKRPERIDEDNSHLVNRMANIVRPKSEEVEEDEEEEEQTFRDINEDWAAGETPREMEEDWANETPNRMMTPMQVDDESDNSVGVESEDEDGGGQFVDYSQRNKWGLDWNSNLNVAIEEDEEEEVVGVGRVEGEDDAEMSESSEDDDVPANNAANNYDRESEGYSSSDS
Protein: Cyclin-A2 (Cyclin-A) (P30274)
Organism: Bos taurus (Bovine)
Function: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P20248}. Cytoplasm {ECO:0000250|UniProtKB:P20248}. Note=Exclusively nuclear during interphase. Detected in the nucleus and the cytoplasm at prophase. Cytoplasmic when associated with SCAPER. {ECO:0000250|UniProtKB:P20248}.
Interaction partners:
- Cell division control protein
- G2/mitotic-specific cyclin-B2
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 2
- E2F transcription factor 1
- Aurora kinase B
- Cyclin-dependent kinase 4
- Histone H3-like centromeric protein A
- Cell division cycle protein 20 homolog
- G2/mitotic-specific cyclin-B1
Sequence:
MLGSSAHGPAAREAGSAVTLQQTAFQEDQENVNPEKAAPAQQPRTRAGLAVLRAGNSRGPAPQRPKTRRVAPLKDLPINDEYVPVPPWKANNKQPAFTIHVDEAEEEIQKRPTESKKSESEDVLAFNSAVTLPGPRKPLAPLDYPMDGSFESPHTMEMSVVLEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHGVSLLNPPETLNV
Protein: Protein ZNF365 (DISC1-binding zinc-finger protein) (Q5PQS2)
Organism: Rattus norvegicus (Rat)
Function: Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery. Contributes to genomic stability by preventing telomere dysfunction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q70YC5}.
Interaction partners:
- Disrupted in schizophrenia 1 homolog
Sequence:
MQQTTFEESRYRWQDSLENVAVCLPFRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTKCSLLPSLKDTDLLRSSELPKQGKLLRGHAKVTKQKPSYVNLYSISHGHSKDPKPFEMVAERPVSYVQTYTAVDIRADSLDAPRSSSGLPTQDTKAAFEAHVREKFNRMVEAVDRTIEKRIDKLTKELAQKTAELLEVRAAFVQLTQKKQEVQRRERALHKQVDVAVEMIAVLKQRLTESEEELLRKEEEVVTFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQASGFSHDTSEHMLTDISSSRKSRCLSRGHQHSVCNHPELKAHFHLKGRSYLKKAKDERAGMQPAKAIHEQAESPREFFRPAKKGEHLGLSRKGNFRPKMAKKKPTAIVNII
Protein: Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor) (CD antigen CD267) (Q9ET35)
Organism: Mus musculus (Mouse)
Function: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 13B
- Tumor necrosis factor ligand superfamily member 13
- Guided entry of tail-anchored proteins factor CAMLG
- Tumor necrosis factor receptor superfamily member 13C
- Tumor necrosis factor receptor superfamily member 17
- CD40 ligand
- Myeloid differentiation primary response protein MyD88
- Tumor necrosis factor
- Tumor necrosis factor receptor superfamily member 5
- TNF receptor-associated factor 6
Sequence:
MAMAFCPKDQYWDSSRKSCVSCALTCSQRSQRTCTDFCKFINCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKRPRSQANLQPELGRPQAGEVEVRSDNSGRHQGSEHGPGLRLSSDQLTLYCTLGVCLCAIFCCFLVALASFLRRRGEPLPSQPAGPRGSQANSPHAHRPVTEACDEVTASPQPVETCSFCFPERSSPTQESAPRSLGIHGFAGTAAPQPCMRATVGGLGVLRASTGDARPAT
Protein: Homeobox-leucine zipper protein HAT4 (HD-ZIP protein ATHB-2) (Homeodomain transcription factor ATHB-2) (Homeodomain-leucine zipper protein HAT4) (HD-ZIP protein 4) (Q05466)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the negative regulation of cell elongation and specific cell proliferation processes such as lateral root formation and secondary growth of the vascular system. Acts as mediator of the red/far-red light effects on leaf cell expansion in the shading response. Binds to the DNA sequence 5'-CAAT[GC]ATTG-3'. Negatively regulates its own expression.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor PIL1
- Transcription factor HFR1
- Transcription factor PIF5
- Auxin-responsive protein IAA29
- Transcription factor PIF4
- Transcription factor PAR1
- Phytochrome B
- Auxin-responsive protein IAA19
- Transcription factor PIF3
- Xyloglucan endotransglucosylase/hydrolase protein 15
Sequence:
MMFEKDDLGLSLGLNFPKKQINLKSNPSVSVTPSSSSFGLFRRSSWNESFTSSVPNSDSSQKETRTFIRGIDVNRPPSTAEYGDEDAGVSSPNSTVSSSTGKRSEREEDTDPQGSRGISDDEDGDNSRKKLRLSKDQSAILEETFKDHSTLNPKQKQALAKQLGLRARQVEVWFQNRRARTKLKQTEVDCEFLRRCCENLTEENRRLQKEVTELRALKLSPQFYMHMSPPTTLTMCPSCEHVSVPPPQPQAATSAHHRSLPVNAWAPATRISHGLTFDALRPRS
Protein: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) (Q2QLA4)
Organism: Equus caballus (Horse)
Function: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity). {ECO:0000250}.
Interaction partners:
- Phospholipase D family member 6
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- Protein boule-like
- DNA-binding protein REPIN1
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- DNA endonuclease RBBP8
- RNA helicase
- Spermatosis associated 22
- CCCTC-binding factor
Sequence:
MAAARFRGLAVAGGGESSESEDDGWEIGYLDRAAQKLKEPLPIEEKNETFKRALTAGDVALVEELLDSGISVDSSFRYGWTPLMYAASVSNVDLVRVLLDRGAKASFDKDKQTILITACSARGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKDGKTPSEIAKRNKHLEIFNFLSLTLNPLEGKLQQLTKEETICKLLTTKSDKEKDHIFSSYTAFGDLEIFLHGLGLEHMTDLLKERDITLRHLLTMRKDEFTKNGITNKDQQKILAALKELEVEEIKFGELPEMAKLEISGDEFLNFLLKLNKQCGHLITAVQNIINELPVNSHKIVLEWASPRNFTSVCEELVGKVEDLSEEVCKLKDLIQKLQNERENDPAHIPLMEEVSTWNSRILKRTAITVCGFGFLLFICKLTFQRQ
Protein: Ras association domain-containing protein 1 (Protein 123F2) (Q99MK9)
Organism: Mus musculus (Mouse)
Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity).
Subcellular location: [Isoform A]: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase 4
- GTPase KRas
- GTPase HRas
- Serine/threonine-protein kinase 3
- Ras association domain-containing protein 5
- GTPase NRas
- G1/S-specific cyclin-D1
- Protein salvador homolog 1
- Ras-related protein R-Ras
- Ras-related protein M-Ras
Sequence:
MSAEPELIELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQQHVPGRGHRFQPAGPTTHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWDSALERDTNVDEAVERETPDLSQAETEQKIKDYNGQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGTGRSTAVKRRTSFYLPKDAIKHLHVLSRTRAREVIEALLRKFMVVDDPRKFALFERTERHGQVYLRKLSDDEQPLKLRLLAGPSEKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSRCRQKIQEALHACPLG
Protein: Alanine dehydrogenase (EC 1.4.1.1) (40 kDa antigen) (TB43) (P9WQB1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
Subcellular location: Secreted {ECO:0000269|PubMed:10527947}.
Interaction partners:
- Alanine racemase
- Alanine aminotransferase
- NAD
- HTH-type transcriptional regulator AldR
- Glutamate synthase large chain
Sequence:
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHGQILFTFLHLAASRACTDALLDSGTTSIAYETVQTADGALPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEGAVKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFEGSRPTTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWRAACRSNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA