wanglab/gogpt-training-data huggingface dataset:
Protein: Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) (Q9DBE0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.
Interaction partners:
- Cysteine dioxygenase type 1
- 2-aminoethanethiol dioxygenase
- Bile acid-CoA:amino acid N-acyltransferase
- Acyl-coenzyme A amino acid N-acyltransferase 1
- Acyl-coenzyme A amino acid N-acyltransferase 2
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Glutathione hydrolase 6
- Glutathione hydrolase 1 proenzyme
- Glutathione hydrolase 7
- Glutathione hydrolase 5 proenzyme
Sequence:
MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVCEWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAMNLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGRMIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAWGGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLVEEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL
Protein: Stimulator of interferon genes protein homolog (P0DV10)
Organism: Drosophila eugracilis (Fruit fly)
Function: Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish). Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L.monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish) (By similarity). Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGLR1 and cGLR2 in response to RNA virus in the cytosol. Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP. Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish). Activated in brain in response to Zika virus infection, leading to autophagy (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A0B4LFY9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MIKEMAIANNADEVDNEVRAEKGRKCFYLKKMIGDYIGNTVRIVATVVLADFLQRLYRSVVEYVHCSKYYLPEDRLWTILRRSCTYSNKSRYLVMGFILIGFLRISVSGNYKDVVPTFKFLAYMPLYWIFSNLGHSTLTYSSWVRDSHGLDYAAGMASNYFHGYLKLSLPERKADGLLHRMNVYEDKYNVTFGIKRLIILIPDEMFINGVIQSRILEKATPLETQFINRAGVNRPFKHAVYRLAEKVNGKTYYFAMEGATPMLSFFEAMHSNFSATWQMKELKREIWLKFYTHLNELIKTWPETRNLVELIIYNSHDTKGDLVDVGEMLKSHMELKTKNIDEMIG
Protein: F-box protein GID2 (Protein SLEEPY 1) (Q9STX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:15155881, ECO:0000269|PubMed:15161962}.
Interaction partners:
- DELLA protein RGA
- DELLA protein GAI
- DELLA protein RGL1
- DELLA protein RGL2
- DELLA protein RGL3
- Gibberellin receptor GID1A
- Gibberellin receptor GID1B
- SKP1-like protein 1A
- Gibberellin receptor GID1C
- Gibberellin 3-beta-dioxygenase 1
Sequence:
MKRSTTDSDLAGDAHNETNKKMKSTEEEEIGFSNLDENLVYEVLKHVDAKTLAMSSCVSKIWHKTAQDERLWELICTRHWTNIGCGQNQLRSVVLALGGFRRLHSLYLWPLSKPNPRARFGKDELKLTLSLLSIRYYEKMSFTKRPLPESK
Protein: Polymerase delta-interacting protein 3 (S6K1 Aly/REF-like target) (SKAR) (Q8BG81)
Organism: Mus musculus (Mouse)
Function: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nucleocytoplasmic shuttling protein. {ECO:0000250}.
Interaction partners:
- SAP domain-containing ribonucleoprotein
- Chromatin target of PRMT1 protein
- Eukaryotic initiation factor 4A-III
- Spliceosome RNA helicase Ddx39b
- Nuclear cap-binding protein subunit 1
- Zinc finger CCCH domain-containing protein 11A
- Protein mago nashi homolog
- Protein mago nashi homolog 2
- ATP-dependent RNA helicase DDX39A
- THO complex subunit 1
Sequence:
MADLSLDELIRKRGTAAKGRLSVRPGIGGVRSRVGIQHSLVNQPARTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQGTVPQKPRQVADAREKISLKRRSPAAFTSPPIGTVTPALKLTKTIQVPQQKAMVPLHAHPAGMRINVVNNHQAKQNLYDLDEDDDIVVPVPPKQMKFAATGSLVHHMTGLSSSKLSMSKALPLTKVVQNDAYTAPVLPSSVRTKALTSMSRTLVNKEEPPKELPPAEPVLSPLEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKCNLHMNGNVITSDQPILLRLSDSPSVKKESELPRRGNPASSNPPAEVDPDTVLRALFKSSGASVTTQPTEFKIKL
Protein: Origin recognition complex subunit 1 (F1QLF9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365058}.
Interaction partners:
- Origin recognition complex, subunit 2.
- Cell division control protein
- DNA replication licensing factor MCM2
- Origin recognition complex subunit 5
- Origin recognition complex subunit 6
- Chromatin licensing and DNA replication factor 1
- Origin recognition complex subunit 3
- Origin recognition complex subunit 4
- DNA helicase
- DNA replication licensing factor MCM4
Sequence:
MSRYITRLSMRRTYKWNGRPVGEDRKLRRQYYGSMSISVDGRTEDVTVSLGQYILIEGENDDNPFVAQLLKLYTDESGKMKTAVVQWFVRMYEVPQYKRKLLGRDPHPQEVFFYQDSSCDNEVDGESILAPVQIMYIAPEHPFPEGKSKDMLFVKHSWDTKSFQAVDPELIEPPPSPKSPPPSSRGPQARPLPTPDPSIMKRAITGAITRGSMSTGKMSSTEAESLHSASKLSAAKALSAKRRSRASSGPHVRKKLELCSPSKNMSRDDVLGEILDKHIDTDKTLMSKMNTSPSGRISISIRLTPLKCNEEQQILPLSSHSPDKPTLTAYGSDSATSVFLGVPALGDDDPESLNNTGRTPRKREATPRRASVRGLKARTPSRRKDSASLKEPALTALAEEEHEDSPAQTAATPRSKRKSAQLVSSRIRKQLNLIANKFDLQSDGEDGDEDDCFVPSKIDLQSSSDEELEAKVDSEDELVVKKRRGSRTPRATDKSCVSARTPCKTPSKKAAPSTPRTPRHATPSIPSRTAPARKPGNVLEEARARLHVSAVPESLPCREQEFQDIYNFVESKVIDGTGGCMYISGVPGTGKTATVHEVIRSLQQSAEQDEIPHFNFIEINGMKMTDPHQAYVQILQKLTDQKATSDHAAALLEKRFSAPAPKKETTVLLVDELDLLWTRKQNVMYNLFDWPTRRNARLVVLTIANTMDLPERIMINRVASRLGLTRMSFQPYTFKQLQQIITSRLNRVKAFEEDALQLVSRKVAALSGDARRCLDICRRATEICEHSGNQQKGSGLVGMSHVMEALDEMFSSSYIAAIRSASVQEQLLLRAVIAEFRRLGLEEATFQQVFVQHQALCRVEGLQPVSVSEGLLVCQRLGSCRLLLLEGSRLDLFLRIRLNVSQDDVLYALKAD
Protein: Ferric uptake regulation protein (Q4KKK3)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU364037}.
Interaction partners:
- Zinc import ATP-binding protein ZnuC
- High-affinity zinc uptake system membrane protein ZnuB
- High-affinity zinc uptake system protein ZnuA
- Putative lipoprotein
Sequence:
MPKTPLASRPHDHSHCVHSALSEADALCARQGLRLTALRRRVLELVWQSHKPLGAYDILAVLSEQDGRRAAPPTVYRALDFLLENGLVHRIASLNAFVGCNHPEHAHQGQFLICRECHAAIELEQKSISDAIISSARDVGFVVEGQTVEVVGLCSGCQGA
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (H3BS86)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAIMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACIEAKHDKYMADMDELFSQVDEKRKKRDIPDYLC
Protein: Nuclear receptor subfamily 5, group A, member 1a (Steroidogenic factor 1a isoform X1) (F1QJG0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- WT1 transcription factor b.
- Wilms tumor protein homolog
Sequence:
MDFRADEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCTQNQDCGIDKTQRKRCPFCRFQKCLSVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKRALIRASGFKLEANGTLLSGQTEFSSVGLQSPYDCPPPALGVALQNYGSFPAQYQYTAPSLPKSIKAEYPDAYSSSPDSTLGYSYADGCLSASPHSVPINPALPPLVLELQSCDPDEEQVRGKICAYLHQEQSGRGKLEKSRPFSLLCVMADQTLFSIVEWARSCVFFKELKVGDQMRLLHNCWSELLLLDHICRQVHHGRDGSLLLITGQEVELSAVLDAGPPLSSMVERGQDLSRRLQLLQVDSREMACLKFLILFNPNVKLLENPQFVESVQEQVNGALLEYTLFSYPQCVERFSQLILRLPELRSLSAEAEDFLCYKHLCGEVPCNNLLIEMLHAKRSSAQ
Protein: Protein lap4 (Protein scribble) (Protein smell-impaired) (Q7KRY7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.
Subcellular location: Cytoplasm. Apicolateral cell membrane {ECO:0000269|PubMed:10884224}; Peripheral membrane protein. Cell junction, septate junction {ECO:0000269|PubMed:10688207}. Note=Localized to epithelial septate junction at the boundary of the apical and basolateral cell surfaces.
Interaction partners:
- Protein crumbs
- Disks large 1 tumor suppressor protein
- Atypical protein kinase C
- Tumor necrosis factor family member eiger
- Rho-type guanine nucleotide exchange factor, isoform F
- Protein PALS1
- Ras-like protein 1
- Stress-activated protein kinase JNK
- DE-cadherin
- LD29223p
Sequence:
MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQQPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAKPTPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKLRQEEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVDNAALGHFDDAEDMRNPLDEIEAVFRS
Protein: HCG1773630 (cDNA, FLJ92308, Homo sapiens adipose specific 2 (APM2), mRNA) (Q5TBU5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASKGLQDLKQQVEGTAQEAVSAAGAAAQQVVDQATEAGQKAMDQLAKTTQETIDKTANQASDTFSGIGKKFGLLK
Protein: Factor arrest protein 10 (Q06001)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Participates in the control of the reentry into the cell cycle following pheromone treatment.
Subcellular location: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Factor arrest protein 3
- Factor arrest protein 11
- Factor arrest protein 8
- Factor arrest protein 7
- 2-oxoglutarate dehydrogenase, mitochondrial
- Serine/threonine-protein phosphatase PP2A-like PPG1
- Vacuolar protein sorting-associated protein 64
- Putative uncharacterized membrane protein YDR199W
Sequence:
MTGPGPEINKEEHPSSPGKKQITYNSIPKNANLIDGSTNSSKRPIEKYDKRIADPTKSYFPHSISRTPRRKYTYILVLTSLNGTFESKHVVIPFKPDGLKLGRPVANSNSSSSSSLRGGKRVDSHTFSQVRSDNGNFDSRVLSRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIEHRKISATVEELFVQPLLESPIFENEDSDDCHTITEKEEAAAITSHIYGDSNNLELEEVILGSDTEILSGIFINNCIGTSPTLSNIIKTLAMEIPFSKCDNFKLQSMENFLINYTTHLEYTNKLLVEKNDQQLVKLQNGLRRKLSGKYEKIIEQNRNQVKQLERDHMFFKKSFEVKKRRNNEKQKSMEREIEDLKTRLEVERYKNSQMMKKNKQKEQELSTASKKKTTEHDTRGVPGMNPKGTDKFSIKNTLCNHFTLLTFGTISIGIIAIVFKILSPN
Protein: Mitochondrial fission 1 protein (A5HUN3)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
Sequence:
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIMLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
Protein: DNA-binding response regulator MtrA (P9WGM7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the two-component regulatory system MtrA/MtrB. Binds direct repeat motifs of sequence 5'-GTCACAGCG-3', phosphorylation confers higher affinity. Overexpression decreases bacteria viability upon infection of human THP-1 macrophage cell line, due at least in part to impaired blockage of phagosome-lysosome fusion (upon infection bacteria usually remain in phagosomes). Infecting C57BL/6 mice with an overexpressing strain leads to an attentuated infection in both spleen and lungs. The level of dnaA mRNA increases dramatically. Binds the promoter of dnaA, fbpD, ripA and itself, as well as oriC, which it may regulate. Upon co-overexpression of MrtA and MtrB growth in macrophages is partially restored, dnaA expression is not induced, although mouse infections are still attenuated, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:16629667}.
Interaction partners:
- Sensor histidine kinase MtrB
- Sensor-type histidine kinase PrrB
- Sensor-like histidine kinase SenX3
- Lipoprotein LpqB
- Sensor histidine kinase component HK1
- Sensor histidine kinase TrcS
- Probable sensor histidine kinase TcrY
- Signal transduction histidine-protein kinase/phosphatase MprB
- histidine kinase
- Sensor protein KdpD
Sequence:
MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
Protein: Cell division protein FtsZ (P45500)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00909}.
Interaction partners:
- Cell division protein SepF 2
- Cell division protein FtsQ
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Cell division protein SepF 1
- Probable peptidoglycan glycosyltransferase FtsW
- Cell division protein SepF 3
- Cell division protein
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- Cell shape-determining protein MreB
- Probable cell division protein WhiA
Sequence:
MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPSKRDNVLGSSSAKREEPTPARPSESRPSFGSLGSVKPKEEPEPAPVPEPVADLPVSPPPVPPSRTYSDSAAEELDVPDFLK
Protein: Putative imidazole glycerol phosphate synthase subunit hisF2 (EC 4.3.2.10) (IGP synthase cyclase subunit) (IGP synthase subunit hisF2) (ImGP synthase subunit hisF2) (IGPS subunit hisF2) (P72139)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Imidazole glycerol phosphate synthase subunit HisH 1
- Imidazole glycerol phosphate synthase subunit HisH 2
- Imidazoleglycerol-phosphate dehydratase
- 1-
- LPS biosynthesis protein WbpG
- UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase
- Phosphoribosyl-AMP cyclohydrolase
- UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
- Histidinol dehydrogenase
- Phosphoribosyl-ATP pyrophosphatase
Sequence:
MVRRRVIPCLLLKDRGLVKTVKFKEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQEPNYELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKFGSQSVVGSIDCRKGFWGGHSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSIDRDGVQKGFDNALVENIASNVHVPVIACGGAGSIADLIDLFERTCVSAVAAGSLFVFHGKHRAVLISYPDVNKLDVG
Protein: MX dynamin like GTPase 1 (H9KVC7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG
Protein: APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) (Q5JTC6)
Organism: Homo sapiens (Human)
Function: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Interaction partners:
- Axin-1
- Adenomatous polyposis coli protein
- Glycogen synthase kinase-3 beta
- Catenin beta-1
- Kelch-like ECH-associated protein 1
- Casein kinase I isoform alpha
- F-box/WD repeat-containing protein 1A
- Wilms tumor protein
- Segment polarity protein dishevelled homolog DVL-1
- F-box/WD repeat-containing protein 11
Sequence:
METQKDEAAQAKGAAASGSTREQTAEKGAKNKAAEATEGPTSEPSSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAAHGPEDVVSEGTGFSLPLPELPCQFPSSQSAHGALETGSRCKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEPGAKGPERVRARPHEHVSSAPQVPCFEETFQAPRKENANPQDAPGPKVSPTPEPSPPATEKMACKDPEKPMEACASAHVQPKPAPEASSLEEPHSPETGEKVVAGEVNPPNGPVGDPLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEEVELEEEEEEVKEEEEDDDLEYLWETAQMYPRPNMNLGYHPTTSPGHHGYMLLDPVRSYPGLAPGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVRRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHGRSSEMFDPFLNFEPFLSSRPPGAMETEEERLVTIQKQLLYWELRREQLEAQEARAREAHAREAHAREAYTREAYGREAYAREAHTWEAHGREARTREAQAREVRCRETQVRETQARQEKPVLEYQMRPLGPSVMGLAAGVSGTSQISHRGITSAFPTTASSEPDWRDFRPLEKRYEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEDPEEEEVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYHKHAFNNYHSRFYQGLPWGVSSLPRYLGLPGLHPRPPPAAMALNRRSRSLDTAETLEMELSNSHLVQGYLESDELQAQQEDSDEEDEEEEEGEWSRDSPLSLYTEPPGAYDWPAWAPCPLPVGPGPAWISPNQLDRPSSQSPYRQATCCIPPMTMSISLSVPESRAPGESGPQLARPSHLHLPMGPCYNLQPQASQSMRARPRDVLLPVDEPSCSSSSGGFSPSPLPQAKPVGITHGIPQLPRVRPEHPQPQPTHYGPSSLDLSKERAEQGASLATSYSSTAMNGNLAK
Protein: Heat shock 70 kDa protein 13 (Stress-70 protein chaperone microsome-associated 60 kDa protein) (Q20752)
Organism: Caenorhabditis elegans
Subcellular location: Microsome {ECO:0000256|ARBA:ARBA00004144}.
Interaction partners:
- DNaJ domain
- Endoplasmin homolog
- DNaJ domain
- GrpE protein homolog
- J domain-containing protein
- J domain-containing protein
- DnaJ homolog dnj-10
- Heat shock protein 90
- Thioredoxin domain-containing protein
- DnaJ homolog subfamily C member 10
Sequence:
MAGATGSLLAGGIFILLLAGWLGQKYGLPPPPPKIAGIDLGTTYSSIGIYHAVTGETIILPDDLGKKSVPSVVAFLPNGTVLIGTRATEQQEHNPKRTIYDAKRFIGRNFEKNNKDFLSDQKRYPFKINLDSEGKAFFEIPLDSGTKNVYPEEIGSLIIGYLKSAAAKHLGVTLGQVVISCPAEFNEKQRNFTAKAAEIAEMEVRRVISEPTAAALAYGLHKKQGVENVVVVDLGGGTLDVSVLWLQGGVFVTQAMAGNNRLGGQDFNDRVQKHLISKIAEKFGKTIDNKEDIQQIRMEVEKGKIRLTNVPSTTISLNLKTVGKWNYELTRDEFETLNGDLLKAIELPITAALADANLDTADVDEIVLVGGSTQVPAVRKIVGRFFKKSANYGVDPELAVVTGASVQAGVIGGGWPLQVAAMELPAKRRKRHFFTEEQKENEKDRTISEL
Protein: AAR187Cp (Q75E93)
Organism: Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Ashbya gossypii)
Interaction partners:
- Structural maintenance of chromosomes protein
- N-acetyltransferase ECO1
- AGL076Wp
Sequence:
MPMKVYGRHGRYNRLVTTFGKTHGEEDSWFSSDDENHGRPVSDDTTKLSLSQDRCSELPEETIGANRKRPAERTQTDPVWEFLERPASGQKRRRRATCDSTEYRESASQEFLNAVNVVQGIVSSLKPAKEVVEHWAELEDVPEDRGNNGQAVYGKTRTMLAKAEEDSDTEAAAHESDERAAQGDEALSRHFNELRTMGETLKYSEDLDFILSDNSMTTPEHRRNNMLRLCLDMMNNEDLCQYIVKYRHREVWEWCFQGTDPKQKVTSLLQCFIADKIPLLRHDKRWAMLSLENFILPLATDEVFPKKIAGSRLVKLNYQDLLRKLKFTNTCEYALYIWATYLLYTEAVYGAVPALARLISRGQLKDWDTACSLLENNIVAAPSGSDIEEYAQAFQTLAGLSREKLTNEGVLKCLIKLTNHTTVLELSADLLPSLVRSLAMSVQLHQNNIVSSISEIKTNLLILQLGLLLNIVSEATTAASTEELTNFGAVFRSVFVKKPTEMSFVLQLFLLVYAYSAGAAGVQLPPAEADFLKSELEAFATDVSSYNHNIHTRITRVLETL
Protein: E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152) (Q8BG47)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (By similarity).
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q8N8N0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8N8N0}.
Interaction partners:
- Ras-related GTP-binding protein A
- Ras-related GTP-binding protein B
Sequence:
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPPEAVEEEPDRRGVVKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG