wanglab/gogpt-training-data huggingface dataset:
Protein: P-loop containing nucleoside triphosphate hydrolases superfamily protein (Q9SZW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transducin/WD40 repeat-like superfamily protein
- Transducin/WD40 repeat-like superfamily protein
- Transducin/WD40 repeat-like superfamily protein
- 5'-3' exoribonuclease 2
- DEAD-box ATP-dependent RNA helicase FANCM
- non-specific serine/threonine protein kinase
- tRNA-splicing endonuclease subunit Sen2-1
Sequence:
MASEGKLLFDLNELPTEDDDGIDNVNFNQQPQVTIPSSNPSSSALLATPSSSQDNVNNNRVFSHASTVSGFQPFVRPVAAQHTDVAVERKVDEGSLEEAKVTSLKVPNDVGAPEREEGEWTESEVPANDNVHSSSDYSTVTEKDNGTLGLDINSDSALQKKNVNHISESSGKDSGSIDSPQEQGLTVRPRETKGVEASHAIKCANTTVKRKMDHQKETMLGKKRHRQTMFLNLDDVRQAGPIKTTTPRRQNFPQPVVTRTVRESRAGPPTAEQAGGVPGHVVYRDQKPIDIPNGGIHPETSEPKLESNGESQSGSAGKTRRMNGEAGPSAEATSTSVSRQGSWKQPINSRQLKSGHSSNRQVPLCSQTSADSKFGNKKFTSFKKQATNSTQYQDTSVERLLREVTNEKFWHHPEDTDLQSVPERFESMDEYVRVFEPLLFEECRAQLYSTWEELAEANSYMKVRIKFIERRERGWYDVILNSVNECKWAFKEGDVAVLSNPVPESEGEHDDVGRVAGTVRRYIPVDTRDPHGAILHFYVGDAYDSGSKIDDNHILRKLKPKEIWHLTVLGSIATTQREYVALHAFSQLNPQMQNAILKPSPEQFPNYGEQTPTVPDCFTPSFAGHLHRSFNAPQLAAIHWAAMHTAAGTSSGVKRQDPWPFTLVQGPPGTGKTHTVWGMLNVIHLVQYQQYYTSLLKKLAPESYKQVNESSSDNIVSGSIDEVLQNMDQNLFRTLPKLCAKPRMLVCAPSNAATDELLSRVLDRGFIDGEMRVYRPDVARVGVDTQTKAAQAVSVERRSDLLLAKSREEILGHIHNLRVRDAQLSQDIAGLKRELTAAAFANRSQGSVGVDPDVLMVRDQTRDAMLQRLSAVVEARDKDLVEMSRLLIVEGKFRAGTSFNLEEARASLEASFANEAEIVFTTVSSSGRKLFSRLTHGFDMVVIDEAAQASEVGVLPPLALGAARCVLVGDPQQLPATVISKAAGTLLYSRSLFERFQLAGCPTLLLTVQYRMHPQIRDFPSRYFYQGRLTDSESVSTAPDEIYYKDSVLKPYLFFDISHGRESHRGGSVSYENIDEARFCVGVYLHLQRTLKSLGGGKVSVGVITPYKLQLKCLKIEFGNALSQDELQEIYINTVDAFQGQERDVIIMSCVRASNHGVGFVADIRRMNVALTRAKRALWVMGNASALMKCEDWAALITDAKARNCFMEMESLPKDFPVPKVPSFIPKAPNARGFRSGGPRTRSIDMHPESRSGTPSEDDKKLSTTTFPRNGNSRRENSVDDSDPPGDRYRDAWQHGIQRRQNFGRPLGRRD
Protein: Type VI secretion protein (D3GUW0)
Organism: Escherichia coli O44:H18 (strain 042 / EAEC)
Interaction partners:
Sequence:
MAIPVYLWLKDDGGADIKGSVDVQDREGSIEVVAQEHCLYIPTDNNTGKLTGTRIHTPFLFTKEIDSSSPYLYKAVTTGQTLKSAEFKWYKINDAGQEVEYFNTKLENVKVVKVNPVMHDIKNPAYEKHNHLEQVELRYEKITWTYKDGNIIHSDAWSERTTA
Protein: Disease resistance protein RPS4B (EC 3.2.2.6) (Q9FHF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Disease resistance (R) protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae. Heterodimerization with RRS1B is required to form a functional complex to recognize AvrRps4 and to mediate the hypersensitive response.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- HXXXD-type acyl-transferase family protein
- Probable receptor-like protein kinase At5g39020
- Cytochrome P450 76C3
- Probable receptor-like protein kinase At2g21480
- Putative receptor-like protein kinase At5g39000
- Probable receptor-like protein kinase At4g39110
- Probable receptor-like protein kinase At5g38990
- Defensin-like protein 208
- Ethylene-responsive transcription factor ERF091
- L-type lectin-domain containing receptor kinase IX.1
Sequence:
MAASSSSTGLPPQHQVFINFRGEDLRLGFVSHLVEALENDNIKVFIDNYADKGEPLETLLTKIHDSKIALAIFSGKYTESTWCLRELAMIKDCVEKGKLVAIPIFYKVDPSTVRGVRGQFGDAFRDLEERDVIKKKEWKQALKWIPGLIGITVHDKSPESEILNEIVKEVKKVLKKVSLEGSQKVVSVDPSQSIDTLSSVGGEKDKTFGIKQRLKELEEKLDLVKYKGTRVIGVVGMPGIGKTTLVKELYKTWQGKFSRYALIDQIRGKSNNFRLECLPTLLLEKLLPELNNPQLDSIEEPYKTHKGLLRERKVLVVLDDVSRREQIYALLGKYDLHSKHEWIKDGSRIIIATNDISSLKGLVHDTYVVRQLNHRDGLQLFRYHAFHYDQATPPKVDFMKLSDEFVHYARGHPLALKILGRELYEKNMKHWETKLIILAQSPTTYIGEVVQVSYDELSLAQKDAFLDIACFRSQDVDYVESLLVSSDPGSAEAIKALKNKFLIDTCDGRVEMHDLLYRFSRELDLKASTQGGSKQRRLWVRQDIINVQQKTMGAANVRGIFLDLSEVKVETSLDREHFKNMRNLRYLKLYNSHCPHECLTNNKINMPDGLELPLKEVRCLHWLKFPLEELPNDFDPINLVDLKLPYSEIERLWDGVKDTPVLKWVDLNHSSKLCSLSGLSKAQNLQRLNLEGCTSLESLRDVNLTSLKTLTLSNCSNFKEFPLIPENLKALYLDGTSISQLPDNVGNLKRLVLLNMKDCKVLETIPTCVSELKTLQKLVLSGCSKLKEFPEINKSSLKILLLDGTSIKTMPQLPSVQYLCLSRNDHLIYLPAGINQVSQLTRLDLKYCTKLTYVPELPPTLQYLDAHGCSSLKNVAKPLARIMSTVQNHYTFNFTNCGNLEQAAKEEITSYAQRKCQLLSDARKHYNEGSEALFSTCFPGCEVPSWFGHEAVGSLLQRKLLPHWHDKRLSGIALCAVVSFPDSQDQLSCFSVTCTFKIKAEDKSWVPFTCPVGIWTREGNKKDRIESDHVFIAYISSPHSIRCLEEKNSDKCNFSEASLEFTVTSDTSGIGVFKVLKCGLSLVYENDKNKNSSLEAKYDVPVEVSFQEPEHGIMEEERYINKRRSDDRRPKKKRKTKRDDIMIISTVTQTCVPSVNARIEDKVTG
Protein: SRY-box containing gene 17 (SRY-box transcription factor 17) (Transcription factor SOX-17) (Q5PQZ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Forkhead box protein A2
- POU domain, class 5, transcription factor 1
- Transcription factor 7-like 1-A
- Lymphoid enhancer-binding factor 1
- Transcription factor 7-like 2
- Transcription factor 7.
- T-box transcription factor T-A
- GATA-binding protein 6
- T-box transcription factor Tb.
- Homeobox protein MIXL1
Sequence:
MSSPDAGYSSDDPSQTSSCSSVMMPGMGQCPWVDPLSPLSDSKSKHEKCSAAGPGRGKSEPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALPMVDKRPFVEEAERLRVKHMQDHPNYKYRPRRRKQVKRNKRLEPSFPLPGMCDAKMTLCTEGMSAGYSGAGLPQYCENHTLFESYSLPTPDPSPMDAGTTEFFAQLQDQSAFSYHHQQEHHFQEQTNILNDTHCHGNTQTLKSRQSHSIAYSNINTNTNSNLHAPINAQLSSINLQQVFHENANPQISHHPGTHLNIFNRSPSSSSHHAMTPAYLNCPSTLDTFYNSSSQMKELSHCVSSHTHKQQSIAEAQSQASTATHSSGQMVDEVEFEHCLSFGVPSAPLPGSDLISTVLSDASSAVYYCGYNNS
Protein: Probable guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (O14057)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Interaction partners:
- Adenine phosphoribosyltransferase
- Putative purine nucleoside phosphorylase
- Adenine deaminase
- Uncharacterized protein C1683.06c
- Uricase
- Uncharacterized deaminase C1683.02
- Inosine-5'-monophosphate dehydrogenase
- m7GpppX diphosphatase
- Phosphoglucomutase
Sequence:
MDGHTCDVFVGKLIHTPSLGELEITDATVGVYNGKIVFLEKSMTPKTLEEAKSHHLLKEATIHKLKPLQFMFPGLIDTHIHAPQYPNSGIGIDVPLLQWLEKYTFPLESSLADLEEARQVYKRVVERTLSNGTTFASYFSTLHTPTSALLAEICYSYGQRAYIGKCNMNNLSPDHYCEKSAESSLEATRQLISYMSILDPKREMVTPIITPRFAPSCTEDLLSGCGELAEKHNLPIQTHISENTSEIELVKELFPERKSYADVYDYYKLLTPQTILAHAIHLEDEEIELLTKRSSGISHCPTSNSILASGLANVRKLLDSGINVGLGTDVSGGYAPSILIALRHAAMTSRSLSYVLGDPKVMLDLSELLYLATQGGAEVVSRGDQVGSFAVGKYWDALIVDLSAETHSCVDIFERDTWPVMLSKWVFTSDDRNLAQVWVNGRLVSGFEMKANLKNSTPLTNGVTSSGHQVFKELTQAHLLPRTQCVDTPPSCCGGHCCKEESCRTENCKGAYPANATVTVEEDSGMS
Protein: TLR20d protein (Toll-like receptor 13) (W8W3P0)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Protein unc-93 homolog B1-like
- Myeloid differentiation primary response protein MyD88
Sequence:
MTLISVTQFGVMALWIICVSSWTSDKCVMTDGFTNLWRGDDCHNGNLTVSCMDVDNVPLHLAIFPISIQTLCVEMRNKSILHPNDFSRFNKLVELGISGQPAEILPGAFRGLFGLQTLSLTCSLNLSIHSNTFKDLHNLKQLRIFSCSFSVIALDAFDGMKQLTTLMIIQHENNLLSDIKSLSGVLCRIVNNTSSLTSLVLWAEIATLNSPKCIVSNGTTYETPSFYGLQDIFLNFPDLKIVGKGVFEGFKNISFLSMPLNNVLQMQLLQSGVSKVESFQFWQEYSDLESMCEIVYQLSTSYVSITTDHINFSISAIQNCMTLRKMSLESFSQRFIDLSFIHGLRNLQVLTVSQFSLNNTRFTSLCKTQPSPILWLKVMSLYFSSIFSIHRRQFFCMKNLEELNLKYNRIYTIDNFAFLGLQKLKVLNLGHNQLSEIKSFNFFDLHCLEYLNLEANPLVHIEALSFAHLSSIQNVSLGDLNFPPESKIELNLTCVFGSIPRGLTYLYISSGRRPMTLIIGGDGSPNPGLGLHVHGETVSFQECERPFFRAVVELTARTEWILCGSIFAGSYFKFLQRFKLESKLSTSFVDLTSLNTLVHLRDLQLTGVDLNRQTGLAIMFHNLTRLETLMLLGCRIDYLERDLSKDLQSLRELRLVINNELTIMEEFPEPLKSLKYLHIQDLLLQCSCDNAWFDNWAKRNRQVQVIFWQTTLGMKEINCIGEHGTQNFLKFSQIHCSMDVGFILFVSNTLGLLLFMLVVLLHHLAGQYLLALFYITRGWLEEAVFRNNKRRYRYDAFVSYSGKDERWVVEELLPNMEQRGPPFLRLCLHSRDFQLGKDIVDNITDCLYSSRRTVCLVSRHYLRSNWCSLEMKLATDRLRLEQRDILILVFLEDISPRQLSAHHRLARLVKTRTYLDWPKEPEQYQDFWDRLWATLAPKHGQ
Protein: Indole-3-pyruvate monooxygenase YUCCA1 (OsYUCCA1) (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA1) (A0A0P0V5U9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in auxin biosynthesis. Converts the indole-3-pyruvic acid (IPA) produced by the TAA family to indole-3-acetic acid (IAA) (Probable). Functions downstream of TAR2 in auxin biosynthesis. Functions upstream of WOX11, a transcription factor that promotes the development of crown roots.
Interaction partners:
- Tryptophan aminotransferase-related protein 2
- Tryptophan aminotransferase-related protein 1
- Os01g0178000 protein.
- Probable aldehyde oxidase 1
- Amidase 1
- Probable aldehyde oxidase 2
- Probable aldehyde oxidase 3
- Os04g0117900 protein
- Os12g0177900 protein
- aldehyde dehydrogenase
Sequence:
MDNKPAQERRETWVPGAVIVGAGPSGLAAAACLAARGVPATVLERSDSLASTWRHRMYDRLALHLPKRFCELPLLPFPEEYPTYPSKDQFVAYMEAYAAAAGVAPRFGATVEEAAFDAAVGAWRVRLDGGEVLMARWLVVATGENAEPRVPDFPGMQKFAGCAMHTSEYKSGEQFAGKKVLVVGCGNSGMEVSLDLCRHGAKPSMVVRNTVHVLPREMFGLSTFGIAMALLRWLPVQLVDRFLLTAAHLILGNTGQFGLRRPKTGPIELKNLTGRTPVLDVGTLDHIKSGKIKVVGAVKEMTRQGVRFTDGKEEQFDTIILATGYRSNVPSWLKDAGDLFTREGISKVPFPNSWRGRNGLYTVGFTQRGLLGTSSDALNVAKDIHCQWRERDRSAINVLEISNSSF
Protein: Lissencephaly-1 homolog (Pronuclear migration abnormal protein 1) (Q9NDC9)
Organism: Caenorhabditis elegans
Function: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord. Required for neuronal cell differentiation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Chromosome, centromere, kinetochore {ECO:0000305}. Nucleus envelope {ECO:0000305|PubMed:20005871}. Note=Localizes to the plus end of microtubules (By similarity). Concentrates in the vicinity of microtubule asters, kinetochores, the cell cortex and the perinuclear region (PubMed:15331665). Probably recruited to the nuclear envelope by unc-83 (PubMed:20005871). {ECO:0000250|UniProtKB:P63004, ECO:0000269|PubMed:15331665, ECO:0000305|PubMed:20005871}.
Interaction partners:
- Protein nud-2
- Dynein heavy chain, cytoplasmic
- Nuclear migration protein nudC
- Cytoplasmic dynein 2 heavy chain 1
- WD_REPEATS_REGION domain-containing protein
- 1-alkyl-2-acetylglycerophosphocholine esterase
- Platelet-activating factor acetylhydrolase homolog 2
- Phospholipase A2
- Intracellular phospholipase A2
- phospholipase A2
Sequence:
MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPEGNSTHILFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDMSCKVWECR
Protein: Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) (Q9DBF1)
Organism: Mus musculus (Mouse)
Function: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Subcellular location: [Isoform 1]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49419}. Nucleus {ECO:0000250|UniProtKB:P49419}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000250|UniProtKB:P49419}.
Interaction partners:
- Choline dehydrogenase, mitochondrial
- Betaine--homocysteine S-methyltransferase 1
- 4-trimethylaminobutyraldehyde dehydrogenase
- Alpha-aminoadipic semialdehyde synthase, mitochondrial
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Beta-ureidopropionase
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Acetyl-coenzyme A synthetase, cytoplasmic
- Aldehyde oxidase 3
- 4-aminobutyrate aminotransferase, mitochondrial
Sequence:
MWRVPRRLCVQSVKTSKLSGPWSRPAAHMSTLLIHHPQYAWLQDLGLREDNEGVYNGSWGGRGEVITTYCPANNEPIARVRQASLKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDAFREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALIEMWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSVAVTKIIAQVLEDNLLPGAICSLVCGGADIGTTMARDERVNLLSFTGSTQVGKEVALMVQERFGKSLLELGGNNAIIAFEDADLSLVVPSVLFAAVGTAGQRCTTVRRLFLHESIHNEVVDRLRSAYSQIRVGNPWDPNILYGPLHTKQAVSMFVRAVEEAKKQGGTVVYGGKVMDHPGNYVEPTIVTGLAHDAPIVHQETFAPILYVFKFQDEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTSLPLAQGIKFQ
Protein: Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) (Q9H2H9)
Organism: Homo sapiens (Human)
Function: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts. Also regulates synaptic plasticity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}.
Interaction partners:
- Sodium-coupled neutral amino acid symporter 2
- Large neutral amino acids transporter small subunit 1
- Neutral amino acid transporter B
- Sodium channel protein type 11 subunit alpha
- Pre-B-cell leukemia transcription factor 2
- Serotonin N-acetyltransferase
Sequence:
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH
Protein: Puratrophin-1-like, isoform B (Q7KU88)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTAAAALMASDCGELPQLLQNLLVSVERSIERVSLNELQMPMHHDRGEDSLDEANNNGCNNNLLGSPKCALRRSDLITKNKLFNSRYMLRRLTNRQDSMNSTSSGNSNVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNSVGNEASGASTSPALPLYCLGNSFPHIDSDEEASDSIGPGKHHSLETCETELLPSSSIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAACVASAGINCYEMATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMRKTHTLPVASSTPAAAAGKRVSYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSLSSGTSTTSGSSISGGSSSGHNDGGGRHSLHFGKLPGAHSASSTNCSATLELINETQALKLAKSPSGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQLSMESGIVSDMCVTPDQEQSAAESSRSSWSTSTTGASGASTTSASTVILRRYRSYAHAAESASPESGK
Protein: Type VII secretion system protein EssB (P0C053)
Organism: Staphylococcus aureus (strain Newman)
Function: Component of the type VII secretion system (Ess) (Probable). Required for the secretion of EsxA and EsxB.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q2G185}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK
Protein: Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79) (Q8C0V1)
Organism: Mus musculus (Mouse)
Function: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
Subcellular location: Chromosome, telomere {ECO:0000269|PubMed:24413433, ECO:0000269|PubMed:24885367}. Nucleus inner membrane {ECO:0000269|PubMed:26548954}. Note=Localizes to telomeres during meiotic prophase (PubMed:24413433). In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane (PubMed:26548954). {ECO:0000269|PubMed:24413433, ECO:0000269|PubMed:26548954}.
Interaction partners:
- Telomere repeats-binding bouquet formation protein 2
- Membrane-anchored junction protein
- SUN domain-containing protein 1
- Telomeric repeat-binding factor 1
- Protein KASH5
- Leucine-rich repeat and death domain-containing protein 1
- HORMA domain-containing protein 2
- Speedy protein A
- Double-strand-break repair protein rad21-like protein 1
- SUN domain-containing protein 2
Sequence:
MESEKPKKTQEMKTDLKLLLECLKYHMGNPLSQKEVLITIHSVCKQNSDAGIYFREIGGLMFIINLAKSSEQSLVKEAALYTLGSIAEENVYCQQSLCTSELFQDLTGLLTNDDSNTNLKRMSVYVLLVLVSNNRNGQTLVREVGCIEVLSQMFRTVLSNYELNLSDNSVFQSYLLWSSVCSTLCVCVNNPQNDENQMLCCSLFPCVNEWLMNCMRPEVIRPICSFIGLTLANNTHAQNCFVSSGGLDVLCQVLVQLESDSHNTLSSAKLAVIVTKTMDACITDNSAAFTVVLSKYHIVSTLLALLLHESLDSREKFSIILAIGHCTEDCEKNQYELLKNNGLPLMIQALTEFKNEDLSKAATYVLHNCKKITGKLSLSLGQNSFGENEIELKDISEKETLREHWKAAKEILCRIKQFEKGGKEEKQQNRSGHYKDNTPSMKVNIQTNLKRLCADSTGGTRAEDKDINQSRELRSYKPSEIMSKACANENQLTTRKKNTNPVHPFCKEKGQSKIVHETTPSCAQNLDKEKTFDQKDSVSQSSDQVLKHLPHTVKNRKQVPETDPFTLCLDIIDREVGIQATDSCSRMLKYTCSGCIVARKLLNSRNFSKFLHSCAYQCVHHKVIMEAEDKYKNELRKTFICAKKILLTPCRRRQLCKESTASEELKIVHQKPDSKKLPGLEAQALNTSIPEAMERRSPVPGQSGLHKKRRIRKDFTKEEVNYLFHGVKTMGNHWNSILWSFPFQKGRRAVDLAHKYHRLIKGPSCAAL
Protein: Protein adenylyltransferase (EC 2.7.7.108) (AMPylator) (Q6G2A9)
Organism: Bartonella henselae (strain ATCC 49882 / DSM 28221 / CCUG 30454 / Houston 1) (Rochalimaea henselae)
Function: Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host target proteins.
Subcellular location: Secreted. Note=Translocated into the host cell via the type IV secretion system (T4SS).
Interaction partners:
Sequence:
MPKAKAKTKNTEIISPHHYVYPNTTTLKNKYGIKNLNAFLEKCSHDTAKAMINLREESLPEYFDTAYLCHIHQQLFKNTFEWAGYLRHIPFTFADGTTAAMPEMKRTGWKNAFAIGDEIQEGLQRLDQTLAEKNNLQGLTREEFNSEAIELFNSLNQLHPFREGNGRTQRLFFENLAKAAGHQLNFSLITKERMMVASVAVAENGDLEPMQHLFEDISNPEKIRLLKEFMHTMKNTGRNVNDRPVMVAKEGETYTGTYRGAGLEGFALNVKGAYIIGNIDHLPPEQLKILKPGDKITFTAPKAEELKKTLIPKETLVPLTKLEIAEMVAEDAFVHTCRDQICSLSKIVYGSQGVLNKNIIEIIKNPSKGQQLATQIERTPYSVHSLAGFDLICFKTGARVRAEKHVALLSCAVANFTHAVKHARQEITKEHQAEQNRLRQEVPMPSQSLQDLLSLPKEFQQKALGVSPLLQKELTSLLQKVNSRLSSSEQRALRENNHETLAKNLGVSEQKAKEITKTVMKAREVQQKSQTRTVSHSKTLAMAS
Protein: Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) (Q86Y07)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16704422}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16704422}; Single-pass type IV membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:16704422}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8BN21}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16704422}. Nucleus {ECO:0000269|PubMed:16704422}.
Interaction partners:
- B1 bradykinin receptor
- Ankyrin repeat and LEM domain-containing protein 2
- Barrier-to-autointegration factor
- C-Jun-amino-terminal kinase-interacting protein 1
- Kinase suppressor of Ras 1
- Barrier-to-autointegration factor-like protein
Sequence:
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL
Protein: Transmembrane BAX inhibitor motif containing 1 (C9JWV9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLF