wanglab/gogpt-training-data huggingface dataset:
Protein: Transient receptor potential cation channel subfamily V member 4 (B3VP30)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MVEPSEGPRTGPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEDGSPSPSLADPGRPTGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTTDLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYHTTVDYLRLAGEIITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAGLYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCSEDHTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNESYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDNMGKPSCDGHQQSYPPKWRTDDAPL
Protein: Chitinase-like protein Idgf5 (Imaginal disk growth factor protein 5) (Q8T0R7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).
Subcellular location: Secreted {ECO:0000250}. Note=Secreted in hemolymph. It is probably transported to target tissues via hemolymph. {ECO:0000250}.
Interaction partners:
Sequence:
MMWIQKNPFLGLLLCSFLAFFQSTYAEVGKLVCFYDAQSFVREGPAQMSLAELEPALQFCNFLVYGYAGIDAVTYKIKSLDPSLTNDRQHYRHITALRKKYPHVRFLLSVGGDRDVNSEGVADSDKYLRLLEQSEHRKSFQASVLAELNNNGFDGIDLAWQFPKNRPKLQQGVFKRVWGSLRGWFSSSSVDEKSEEHREQFATLLEELQSDLRRGGQLLTVSMLPHVSAELFIDVPKVLSNVDFVNLGTYDFQTPERDPKVADLPTPLYAMYDRDPSHNVQYQVQYWMNQTSEISVHKLHVGVTSYGRAWNMTRNSGITGYPPIPAANGAAPPGRQTVTPGLLSWPEICDLLQQQPQDREVPHLRKVGDPTKRFGIYAYRAADDQGENGLWVGYEDPLTAAIKAGFVHAQGLGGVAFHDLSMDDFRGQCAGEKFPILRSIKFKL
Protein: ORMDL family protein (Q9C5I0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Long chain base biosynthesis protein 1
- Long chain base biosynthesis protein 2a
- Long chain base biosynthesis protein 2b
- serine C-palmitoyltransferase
- Lecithin-cholesterol acyltransferase-like 1
- GLABROUS1 enhancer-binding protein-like 3
- Phosphatidylinositol:ceramide inositolphosphotransferase 2
- Methyltransferase-like protein 2
Sequence:
MANLYVKAVPPPDMNRNTEWFMYPGVWTTYMLILFFGWLVVLSVSGCSPGMAWTVVNLAHFVVTYHSFHWMKGTPFADDQGIYNGLTWWEQMDNGQQLTRNRKFLTLVPVVLYLIASHTTDYRHPWLFLNTLAVMVLVVAKFPNMHKVRIFGINGDK
Protein: Hemolysin secretion protein D, chromosomal (P09986)
Organism: Escherichia coli
Function: Involved in the transport of hemolysin A.
Subcellular location: Cell inner membrane; Single-pass type II membrane protein.
Interaction partners:
Sequence:
MKTWLMGFSEFLLRYKLVWSETWKIRKQLDTPVREKDENEFLPAHLELIETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTLSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQIRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTILARINRYENVSRVEKSRLDDFRSLLHKQAIAKHAVLEQENKYVEAANELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDSIELLTLELEKNEERQQASVIRAPVSGKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQKLGLVFNVIVSVEENDLSTGNKHIPLSSGMAVTAEIKTGMRSVISYLLSPLEESVTESLHER
Protein: Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17) (Q9D8P4)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9NRX2}.
Interaction partners:
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL14
Sequence:
MRLSLAAAISHGRVYRRLGLGPESRIHLLRNLLTGLVRHERIEATWARADEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFKVLAPRFQGQNGNYTRMLQIPNRKEQDRAKMAVIEYKGNYLPPLPLPHRDSNLTLLNQLLLGLQQDLHHNQDASLHSSCTVQTPKT
Protein: Interferon-alpha (Q1XG00)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
ACNHLRLQDATFSHDSLQLLRDMAPTLPQLCPQHNASCSFNDTILDTSNTRQADKTTHDILQHLFKILSSPSTPAHWNDSQRQSLLNRIHRYTQHLEQCLDSSDTRSRTRWPRNPHLTIKKHFSCLHTFLQDNDYSACAWEHVRLQARAWFLHIHNLTGNTRT
Protein: Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) (P35917)
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20445537}; Single-pass type I membrane protein {ECO:0000269|PubMed:20445537}. Cytoplasm {ECO:0000269|PubMed:20445537}. Nucleus {ECO:0000269|PubMed:20445537}. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Interaction partners:
- Vascular endothelial growth factor D
- Vascular endothelial growth factor C
- Vascular endothelial growth factor B
- Placenta growth factor
- Vascular endothelial growth factor A, long form
- Vascular endothelial growth factor receptor 2
- Neuropilin-2
- Platelet-derived growth factor C
- Platelet endothelial cell adhesion molecule
- Angiopoietin-2
Sequence:
MQPGAALNLRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVVHDCEGTEARPYCKVLLLAQTHANNTGSYHCYYKYIKARIEGTTAASTYVFVRDFKHPFINKPDTLLVNRKDSMWVPCLVSIPGLNITLRSQSSALHPDGQEVLWDDRRGMRVPTQLLRDALYLQCETTWGDQNFLSNLFVVHITGNELYDIQLYPKKSMELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVSQNDLGPYVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDELVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKTFAQRSLRRRQQRDGMPQCRDWKEVTTQDAVNPIESLDSWTEFVEGKNKTVSKLVIQDANVSAMYKCVVVNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLLIFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHSSQSSEEDGFMQASTTALHITEADADDSPPSMHCHSLAARYYNCVSFPGRLARGTKTPGSSRMKTFEELPMTPTTYKASMDNQTDSGMVLASEEFEELESRHRPEGSFSCKGPGQHMDIPRGHPDPQGRRRRPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSSY
Protein: Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) (A0A1P8AVS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 2 subunit alpha homolog
Sequence:
MIFLEKATVYYLQFFHFEEFSQEKKKSMWRRSPSFILDERRSSNSPPMADTTRGPFQNPDSISAYYQTRAAHHGVITSDWLAQAQAAVGGVSGDAQHDLSVTDLGNEKSFNVIEEFNNWRKQPDLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDKTSISLTAGCDLFIRYVTRTSALEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFIFDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLLDSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKFARLYPLDQKDMAPALRPIEFGVKIPTKVEVERSARDYTPPQYLTLLFTDLGVLSPSVVSDELIQLYL
Protein: Ionotropic receptor 75a (Q9VVL1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a.
Subcellular location: Cell membrane {ECO:0000305|PubMed:27776356}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:27776356}.
Interaction partners:
- Ionotropic receptor 8a
- IP13856p
- Ionotropic receptor 41a
- Ionotropic receptor 25a
- Ionotropic receptor 76a, isoform E
- Odorant receptor 35a
- Ionotropic receptor 92a
- Ionotropic receptor 40a
- Ionotropic receptor 64a
- Ionotropic receptor 21a
Sequence:
MQLVQLANFVLDNLVQSRIGFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELSYMGHTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLTFHP
Protein: Transcription termination factor MTERF9, chloroplastic (Mitochondrial transcription termination factor 9) (Protein TWIRT1) (Q9FM80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription termination factor required for processing and steady-state levels of plastid transcripts. May play a role in response to abiotic stresses.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21464319}.
Interaction partners:
- Transcription termination factor MTEF18, mitochondrial
- Mitochondrial transcription termination factor family protein
- Holliday junction resolvase MOC1, chloroplastic
- DNA-directed RNA polymerase 3, chloroplastic
- Rho-N domain-containing protein 1
- DNA-directed RNA polymerase subunit alpha
- Mitochondrial transcription termination factor family protein
- Pentatricopeptide repeat-containing protein GUN1, chloroplastic
Sequence:
MAGFSLYCFKNPRILFTLPSESPLFVLGSDKCSPATRRPSRKTRGFVVTYAHSNPKIINPKKKSRYGQTLSPYDSDEDDDDDDDDDDDDWLLNDDFAEVTEYEKKKPKSHKQTIAKKSVKKGIVKPEESETDEDDLDLGISPNATSEKKKESWRLDGRGKMSSRKYVEKLYPRLAEEIDIDPKCVPLLDYLSTFGLKESHFVQMYERHMPSLQINVFSAQERLDYLLSVGVKHRDIKRMLLRQPQILQYTVENNLKAHISFLMGLGIPNSKIGQIVAATPSLFSYSVENSLRPTIRYLIEEVGIKETDVGKVVQLSPQILVQRLDITWNTRYMFLSKELGAPRDSVVKMVKKHPQLLHYSIDDGFLPRINFLRSIGMCNSDILKVLTSLTQVLSLSLEDNLKPKYMYLVNELNNEVHILTKYPMYLSLSLDQRIRPRHRFLVELKKVRKGPFPLSSLVPNDESFCQQWAGTSVDTYLAFRQRLLLKEFANKYDKRG
Protein: Tigger transposable element-derived protein 6 (Q17RP2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MANKGNKKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKDRTKFEEKVREASVGPQRKRMRSALYDDIDKAVFAWFQEIHAKNILVTGSVIRKKALNLANMLGYDNFQASVGWLNRFRDRHGIALKAVCREDSDRLMNGLGIDKINEWHAGEIIKLIADYSPDDIFNADETGVFFQLLPQHTLAAKGDHCRGGKKAKQRLTALFCCNASGTEKMRPLIVGRSASPHCLKNIHSLPCDYRANQWAWMTRDLFNEWLMQVDARMKRAERRILLLIDNCSAHNMLPHLERIQVGYLPSNCTAVLQPLNLGIIHTMKVLYQSHLLKQILLKLNSSEDQEEVDIKQAIDMIAAAWWSVKPSTVVKCWQKAGIVPMEFAECDTESAASEPDIAIEKLWHTVAIATCVPNEVNFQDFVTADDDLIISQDTDIIQDMVAGENTSEAGSEDEGEVSLPEQPKVTITEAISSVQKLRQFLSTCVDIPDAIFGQLNGIDEYLMKRVTQTLIDSKITDFLQTK
Protein: Ethanolamine ammonia-lyase large subunit (EAL large subunit) (EC 4.3.1.7) (Ethanolamine ammonia-lyase alpha subunit) (Ethanolamine ammonia-lyase heavy chain) (Ethanolamine deaminase large subunit) (P0AEJ6)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12. It is spontaneously inactivated by its substrate and reactivated by EutA.
Subcellular location: Bacterial microcompartment {ECO:0000255|HAMAP-Rule:MF_00861}.
Interaction partners:
- Ethanolamine ammonia-lyase small subunit
- Ethanolamine ammonia-lyase reactivase EutA
- Bacterial microcompartment shell protein EutL
- Probable ethanolamine permease EutH
- HTH-type DNA-binding transcriptional activator EutR
- Bacterial microcompartment shell protein EutS
- Corrinoid adenosyltransferase EutT
- Acetate kinase EutQ
- Bacterial microcompartment shell protein EutK
- Glycerophosphodiester phosphodiesterase, periplasmic
Sequence:
MKLKTTLFGNVYQFKDVKEVLAKANELRSGDVLAGVAAASSQERVAAKQVLSEMTVADIRNNPVIAYEDDCVTRLIQDDVNETAYNQIKNWSISELREYVLSDETSVDDIAFTRKGLTSEVVAAVAKICSNADLIYGAKKMPVIKKANTTIGIPGTFSARLQPNDTRDDVQSIAAQIYEGLSFGVGDAVIGVNPVTDDVENLSRVLDTIYGVIDKFNIPTQGCVLAHVTTQIEAIRRGAPGGLIFQSICGSEKGLKEFGVELAMLDEARAVGAEFNRIAGENCLYFETGQGSALSAGANFGADQVTMEARNYGLARHYDPFIVNTVVGFIGPEYLYNDRQIIRAGLEDHFMGKLSGISMGCDCCYTNHADADQNLNENLMILLATAGCNYIMGMPLGDDIMLNYQTTAFHDTATVRQLLNLRPSPEFERWLESMGIMANGRLTKRAGDPSLFF
Protein: Protein S-acyltransferase 10 (EC 2.3.1.225) (Probable palmitoyltransferase At3g51390) (Zinc finger DHHC domain-containing protein At3g51390) (Q7XA86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-acyltransferase involved in protein lipid modification. Catalyzes the palmitoylation of proteins peripheral or integral to the tonoplast. Required for the tonoplast localization of CBL2, CBL3 and CBL6, but not for the plasma membrane localization of CBL9, for the endosome localization of RABF1 or for the endomembrane localization of RABF2B.
Subcellular location: Vacuole membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Transient expression results in mistargeting of PAT10 to the Golgi apparatus, while the non-functional mutant is also localized in Golgi apparatus membranes. {ECO:0000269|PubMed:22968831, ECO:0000269|PubMed:23482856}.
Interaction partners:
- Calcineurin B-like protein 2
- Calcineurin B-like protein 3
- Calcineurin B-like protein 6
- AP-3 complex subunit delta
- Calcineurin B-like protein 1
- Rac-like GTP-binding protein ARAC4
- AP3-complex subunit beta-A
- Hydrophobic protein RCI2A
- CBL-interacting serine/threonine-protein kinase 9
Sequence:
MGVCCPFLQPWDRARDQCLLNLPCLSDPVRRSSLLLKLALVALHLVFIGFLFLFDAEFIEKTKRDPWYMGCYILLFSATLLQYFVTSGSSPGYVVDAMRDVCEASAMYRNPSTTSIQHASRKSESVVVNVEGGSASCPRRPPTPWGKLVLDLYPPGTSIRNLTCGYCHVEQPPRTKHCHDCDRCVLQFDHHCVWLGTCIGQKNHSKFWWYICEETTLCIWTLIMYVDYLSNVAKPWWKNAIIILLLVILAISLIFVLLLLIFHSYLILTNQSTYELVRRRRIPYMRNIPGRVHPFSRGIRRNLYNVCCGNYNLDSLPTAFELEDRSRPYTCIDMLKCRCC
Protein: Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2) (Q8R4P4)
Organism: Mus musculus (Mouse)
Function: Probable ion channel required for the normal function of cochlear hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia tips of the cochlear hair cells and plasma membranes of cuticular plates. {ECO:0000269|PubMed:28504928, ECO:0000269|PubMed:38228630}.
Interaction partners:
- LHFPL tetraspan subfamily member 5 protein
- Calcium and integrin-binding family member 2
- Transmembrane inner ear expressed protein
- Protocadherin-15
- Cadherin-23
- Transmembrane channel-like protein 1
- Whirlin
- Unconventional myosin-VIIa
- Harmonin
Sequence:
MSPQLKSLDEEGDKSARRPTRKQTSRAACPQDGHRAQSSRKDPAKGSPRPGSSRKKQMEHGSYHKGLQGQKPRKVERSLQGRKKDRRTSLKEQRASPKKEREALRKEAGKQLRKPRSTSLGSSVSTGDSLSEEELAQILEQVEEKKKLITTVRNKPWPMAKKLRELREAQAFVEKYEGALGKGKGKHLYAYRMMMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEERAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLMIVIRSMASNTQGSTSEGDSDSFTFSFKMFTSWDYLIGNSETADNKYVSITTSFKESIVDEQESNKEGNIHLTRFLRVLANFLILCCLCGSGYLIYFVVKRSQEFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLSNEEKIKNITHWTLFNYYNSSGGNESVPRPPPHPADVPRGSCWETAVGIEFMRLTVSDMLVTYLTILVGDFLRACFVRFMNHCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTVMSLPPSFDCGPFSGKNRMYDVLHETIENDFPKFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQALREVEKNHKSIKGKAIVTYSEDTIKNSSKNATQIHLTKEEPTSHSSSQIQTLDKKAQGPHTSSTEGGASPSTSWHHVGSQPPRGRRDSGQPQSQTYTGRSPSGKRTQRPHN
Protein: Heat shock transcription factor 2 (V9GZ44)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
HSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQSGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDSENKGLETTKNNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASS
Protein: ATP-dependent L-serine kinase SbnI (EC 2.7.1.225) (Staphyloferrin B biosynthesis regulatory protein SbnI) (Q2G1M5)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Free serine kinase that uses ATP to phosphorylate L-serine to yield O-phospho-L-serine and ADP. O-phospho-L-serine serves as a substrate for SbnA and is a precursor for staphyloferrin B biosynthesis. Is also a DNA-binding regulatory protein that senses heme to control gene expression for siderophore biosynthesis. Binds to DNA within the sbnC coding region and is required for expression of genes in the sbn operon from sbnD onward.
Interaction partners:
- N-
- N-
- Staphyloferrin B synthase
- Staphyloferrin B transporter
- 2-[
- 2-[
- L-2,3-diaminopropanoate--citrate ligase
- HpcH/HpaI aldolase/citrate lyase domain-containing protein
Sequence:
MNHIHEHLKLVPVDKIDLHETFEPLRLEKTKSSIEADDFIRHPILVTAMQHGRYMVIDGVHRYTSLKALGCKKVPVQEIHETQYSISTWQHKVPFGVWWETLQQEHRLPWTTETRQEAPFITMCHGDTEQYLYTKDLGEAHFQVWEKVVASYSGCCSVERIAQGTYPCLSQQDVLMKYQPLSYKEIEAVVHKGETVPAGVTRFNISGRCLNLQVPLALLKQDDDVEQLRNWKQFLADKFANMRCYTEKVYLVEQ
Protein: Cation transporter, putative (Q384C8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MANVNNETTECGALLSNITSLQTTLTSMGCQVPALHHHTHDHGHHHHHHHHDDHTHGADDHEGHGHSHGGCESGHGTYSIGLHVVAIFVVLIASFLGTLIPIIGKYVPALRLPPFVFVLGKCIAAGVLLSVSTIHMINEAVAQLQEDCVPESFRESYEAYAFLFAVAGALLLHMVDVIVDARVTNKSDSSTNKPEGQPDAEEAQAAPAALDAYDGHHCHYAVGMPQSRTRRLVSAMFMEFAVTVHSVFIGLAVGIARDAETKTLLVALAFHQMLEGLALGARLVDAELSLKLEMLFALLFSVSAPLGTAIAVGTIAIWNVSMVGTAFVITQAVASAVCGGMLLYLAFCLMLSDFPSDMQKHAGKDKVRRFFRCFGMFAALWLGAALMAVLGKWV
Protein: Protein fantom (Meckel syndrome protein homolog) (Q09459)
Organism: Caenorhabditis elegans
Function: Thought to have an important role in cilia formation and cilia-mediated chemosensation. Involved in the docking of other MKS/MKSR proteins localized to the transition zone of the cilia.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:21689635}. Note=Localizes to the transition zone.
Interaction partners:
- NePHronoPhthisis
- Nephrocystin-1-like protein
- Transmembrane protein 231
- C2 domain-containing protein
- Transmembrane protein 237 homolog
- TMEM
- Nematode cuticle collagen N-terminal domain-containing protein
- Meckelin
- BBSome complex member BBS1
- MecKel-Gruber Syndrome
Sequence:
MVSARYPIEKWSRPQLEDHFHNVVEELNKAQKKVKEQEKQITTFNSRFRRSMLERKSQNEKVVERSKYDDVVKENQILDMKLKAAKQQLLIYTAPSARATTASMMTGRSTFRQPPSTFRQRPPLTAGTTGSIDRPGSAPVARKKSDGGEKLQLATDEKLAIVRLNRTLKNKNDEITELKYTIEKLRQLKSSVNQSSPPTRLSTSSSSKSSSSNNNNDGEGKDSELEEMSEMSDDESGRSTPVIEEKKKPRRKSRKSSHQEPSKNPIPPPRIPDQTEKVLLDKLKVAENDLAMLQEECDLVKKANERLVHQSLSKSTEYGARESIEEKKKIVELEELLKETEKRIKESEHRRREDQKKFEAMRLHYKNKYDAAKKTEKKLSVVAKNSKVEEERIEEEKISHSPPPMTFEPIRKRHSQSEISRMRRADDDLLQKLYKEVADILHSHDVGIAEINTLGASENSLARWQKLYSELYEELEKVRNMLLIQYDINQKQMKEIKLLKDELDRLKTVSAEILSKSREEVEERQKKIFMLEEQIRTIAYSGQQPVKLLANQINIPTPRVNTDLSVKLINVKPSPSLTSKFFFSLEFFDFQLETTPIMDAKQHNMDFTTVYDVLVSNLLIHYLQTNGIVIEMYRPASDCYKLLAAATISLIPLFEDSVLRKFCSEIMLKSVDTGVEMCTLRYEIEVSQPISDSFKKFKKSEMARNMLPLQLENEDTEDTNFDPLTIMVNRVVGLDTFGKDPSTEFCIVDEFLSFSPYFTDFSTSSEIRSKRDCYIPKIDIARNLFATSSISFFLIENIPRQDGVIATLHLPLHPLCKLGGSIKGTFPMLDTDGRPSSVSLDLCLIWKHEIPSFFLKHEPKEPLKEVKDTPILPQPVRRTSKEFVVTPVKEAELHDAEPTSMPPKAPEPTTAPLRRLSTDSSDTSFSHSSKDLFSPPTNPQTYDYEIPAVTPALVDSDGEEEADRIVFDDDDDEIESVSAVSSQRDPEPLEVPERQVENLPSPEDTPRPSDPLKPNGTNESKESTPVTQRSVDKTDDVAPVDPELEPESGPEPEPVVESEPNEVAETEEDRKRELKTEELKSLLGALPPIAKPRNIPVGPIALTEQPEATRQQGSTGRILFTDPLHFSVPPSESSSTSSPRRAEKAPVPLPDYEGHSLIKVRKPLSPTDKDVLEPNMKVSIQLETFELVPGSSLTPLTREETTFFVDWVFLDFTNEQSKSTIFDFPRRPQEMVDIRYTKEYTLTRGQLSLLDQWIRASIKFELTIIKISPGDEEELGFGSLILVPNNTQNKSFVIDVYDRSGIVQAEMTLTLHFSRALIEQLT
Protein: Heterokaryon incompatibility protein S (Big S protein) (Vegetative incompatibility protein S) (B2ACC7)
Organism: Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Function: Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Interaction with the prion form [het-s] of incompatible cells triggers a lethal reaction that prevents the formation of viable heterokaryons.
Subcellular location: Cytoplasm.
Interaction partners:
- Mitochondrial division protein 1
- Mod-A
Sequence:
MSEPFEIVAGALGVAGLFNNCVACFEYVQLGRHFGRDYERCQLRLDIAKVRLSRWGEAVQINDDPRFHSSAPIDKSVQLAKSIVEEILLLFESAQKTSKRYELVADQQDLVVFEDKDMKPIGRALHRRLKDLVSRRQKQTSLAKKTAWALYDGKSLEKIVDQVAGFVDELEKAFPIEAVCHKLAENEIEEVEDEASLTILKDAAGGIDAAMSDAAAQKIDAIVGRNSAKDIRTEKRARVQLGNVVTAAALHGEIRISDQTTNSVETVVGKGESKVLIGNEYGGKGFWDN
Protein: UDP-galactose/UDP-glucose transporter 2 (AtUTr2) (Q29Q28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar transporter involved in the transport of UDP-galactose form the cytoplasm into the Golgi apparatus.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:15891899}; Multi-pass membrane protein {ECO:0000269|PubMed:15891899}.
Interaction partners:
- UDP-xylose transporter 2
- UDP-xylose transporter 1
- CMP-sialic acid transporter 3
- GDP-mannose transporter GONST1
- UDP-xylose transporter 3
- Sugar transporter ERD6-like 9
- GDP-fucose transporter 1
- UDP-URONIC ACID TRANSPORTER 1
- Sugar transport protein 10
- Sugar transporter ERD6-like 15
Sequence:
MKEEQTRSLFGISLSDKPTWQQFLICTSGFFFGYLVNGVCEEYVYNRLQFSFGWYFTFIQGFVYLFLIYLQGFTTKHIVNPMRTYVKLSAVLMGSHGLTKGSLAYLNYPAQIMFKSTKVLPVMIMGAFIPGLRRKYPVHEYISAFLLVLGLILFTLADAQMSPNFSMIGIMMITGALIMDAFLGNLQEAIFTMNPETTQMEMLFCSTVVGLPFLFVPMVLTGEVFRAWTACAQHPYVYGVLVFEAMATFIGQVSVLSLIALFGAATTALITTARKGVTLLLSYLIFTKPLTEQHGSGLLLIAMGIVLKMVPMDSKAPAKIPARPAVRIAGGDGDREEDEERKSLV