wanglab/gogpt-training-data huggingface dataset:
Protein: MHC class II transactivator type III (Q9GJD9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRCQVPGPSGSYLQGHTLCATMELGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELNSETDMDTINCDQFSKLLQDMEMDEETREAYANIAELDQYVFQDTQLEGLSKDLFIQHIGPEEGFGENVEGPAESGEKPQKRRFPEEHAMDSKHRKLVPPSRTSLNYLDLPAGHIQIFTTLPQGLWQISGVGTGLSSVLVYHGEMPQVNQLLSSSSPTVPSLPESPDRPGSTSPFAPSTADLPGMPEPALTSRVNETEDTTPPSPCQEDPEPSIKLPKWPESVERFQHSLQDKYQALPGSPSGPLVAMELVRARLERGSNKSQERELATPDWTERQLAHGGLAEVLRVVGDSRRSRETQVVAVLGKAGQGKSHWARTVSHIWAQGQLPQYDFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMNDEVIDHIVRQPDRVLLILDAFEELEAQDSLLHGPCGPLSPEPCSLRGLLAGLFQRKLLRGCTLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAQIYMRHYFENSGTAGSHDKALGLLEGQPFLLTHSHSPVLCSAVCQLSKALLDQGAGAQLPCTLTGLYVGLLGPAAQNSPPGALVELAKLAWELGRRHQSTLQETQFPSVEVKTWAVAQGLMQQTTEAQLAFSSFLLQCFLGAVWLAQCNEMKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGALVEPAMAAVADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQEPGIWKHVSHQLPGHLSFLGTRLTAPDVYVLGRALETASQDFSLDLRQTGIEPSRLGDLVGLSCVTSFRASLSDTMALWESLQHQGETQLLQAAEEKFTIEPFKAKSPKDVEDLDSLVQTQRLRNPSADAAKDLPAIRDLKKLEFALGPVLGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARISLR
Protein: Epididymis secretory sperm binding protein Li 78p (Fibrinogen beta chain) (V9HVY1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
Protein: CG32711-PA long isoform (CG32711-PA short isoform) (GEO09706p1) (Leg arista wing complex, isoform A) (Leg arista wing complex, isoform B) (Leg arista wing complex, isoform C) (Leg arista wing complex, isoform D) (Leg-arista-wing complex variant) (RH09582p) (Q8SXG2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLSATHTRSTFSPLCGAAQVLSQQQTRNKSSKTVEVYRDASKNLSFDVVSVRCSSCCCCCCSCCCYCRCLTFL
Protein: Protein XRP2 (O75695)
Organism: Homo sapiens (Human)
Function: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528}; Lipid-anchor {ECO:0000269|PubMed:10942419}; Cytoplasmic side {ECO:0000269|PubMed:10942419}. Cell projection, cilium {ECO:0000269|PubMed:20106869}. Note=Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. {ECO:0000269|PubMed:12417528}.
Interaction partners:
- ADP-ribosylation factor-like protein 3
- Protein unc-119 homolog B
Sequence:
MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI
Protein: SNF2 DNA repair protein, putative (Q580T1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKGNDNDCNAADPEVSQLVIPPELERALHAHQISALHFMWRKLVDNGIERVIRQSRGAPLTDRVRLYQEVFGCIVGHSMGLGKTITALSFLLLLQKHYATSDNVSSKHKVTDSSEASEDEDTAGAPVTASCIRVLVLTPRSCTYHWQSSAEQWMSSSLFGGTQLPLYVPLGNSATDALVLKHYHEGGALLLGYEEYNKLVSRAREVAGGGQSYSRVHSIFDRSRPPLPLTRQVVMSEMLESFDVVVFDESHRFKRPKSRLVTALKQSLHAVQLRIALTGTPLQNHLEEYGVMHSVVTGGAFDLAPFRRLFAIPIERGQCADSTYEQYLEMQKCVASLRRFFSTTVHPCGPEVLKRDLPERREYLILVGLSPQQEDAYRSLLRQFFPDMNKGVILNLHHKASHICCHAMMDNQLVQVLCQSVYVDENGRETHSNLGAGRGVQTPGKDSVTDDCDSESRESSRDESEFSGDISSSSSSTSSSASDLKGQSQANTSKENASVDIWLKRLRIDESPKLNLTLSLLRYISEDLREKVVLFSTYKSHLYLLMFLLRQRGVVSEVLHGGVEVKERQLIIDRFSVDPSLRVLLCSTKALGVGINLVAANHCILFDVSWNPSDDTQATYRLYRYGQRRPVTIYRIATEGTFEHVVFFYALSKSWIHKKIVDVSDPARYDRHVKENYFIYPCPLPVDFEQVDGKPEVRTKLPNGEALQKKWRDYASLHCPSLLHTARDGTFAWIRAITEYSFLVRDSTEEAIREMGLRFEAERRKPLMPVVIEKVMGGSRPVQEKTGNTMQRCEPSLQVCLSGCADQLVSMASQGQAHHEEVQRHVADVSKQEMEKRLTCLLAKVLGVPEPAGGLVEVVTLIFHLGVDHVMQETLNKAPYAKLRSVLNARVLNSKLSEKSLQNSLKFKPFTLFAIMAPTEVTYTLTELGFNRPFAPHCTLVGVRCALRSNNISRDTLQELYNLLASASADVNIGTGDAVTAADVEAVMLKCMESYWPPYAGMALPAPTKGAEQRRSLAERALRVAGEHTTGFVLPREAARYVGISPLTDRCDVYQCQRCNDGLMERMLPEYVLKCGRCHYNAEFDLQSQPETHHACAVYQFSVVCGLLDAFSHFESLKKAFVPLECRGVLHALRRLRQLSKVYTPKEFISSVLRFGVESFLQELPEPTLGLLRLQCGAKDVDTLKDILLSDSSFALSNCVHTHVRQMLINWLKSNTVASSGMHIVTMPEALIILALQLLGKRYKGENGFAKDVLSEAQSGNLCGNAALLRFVCDAVVKLKYIERLLERPLTRATLDAFMMDYATPSGGSSESEGSKPDEQLNGQEKSDDEESKVDEEDEEMHSLSTNSASSPSFRPDSRKRQRSPSLCMSEATVLSTVQSSSYSSCYPGGESLETSVSEDRAESVAYEAMEEGDIQMVRSAHFWASHCEVYGISSTETHTIQIDGEGCTANVLHPPPNSFWAREVHGATHDGMRISSVIDLFLEKLFVLSASVRVIK
Protein: Uncharacterized protein (Q585L9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSYRRPTASSQRRARNHSDTSELSQAESVKSAHGGKANFAFGSIFRECGKRLRGESPTECNDEMEVHLSQQLTKRCDAALERASTLLDKTIKESERNSQTLQDGMGSSSRRSSMSPKKPSSPDKMEGGVTSRGSARLSGTVLKAPPPTPEQTQRDESVANETRESGKWLEKLLGRVSNVVAKARTSPDMKERMLSEDADGGASAASTPHSSPCPLQRPSVGRASMNESTPSRLRKSVTFKDGANLETLTPPPRVPHIYEEEESNPEGNAGEEGGLAEAYMSTQLAGGPAFSSELPSQVTLQFSPAPRAPSRGSSCSRSVDMTNSPELPQTRDVGAVIRGRSSSEAYRELSKEELLLYVKQHHISVKKITTKKELFEVGRRIAEEKTSRAD
Protein: Flavodoxin 1 (Flavodoxin A) (P61949)
Organism: Escherichia coli (strain K12)
Function: Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.
Interaction partners:
- Uncharacterized protein YbfE
- Ferric uptake regulation protein
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Sequence:
MAITGIFFGSDTGNTENIAKMIQKQLGKDVADVHDIAKSSKEDLEAYDILLLGIPTWYYGEAQCDWDDFFPTLEEIDFNGKLVALFGCGDQEDYAEYFCDALGTIRDIIEPRGATIVGHWPTAGYHFEASKGLADDDHFVGLAIDEDRQPELTAERVEKWVKQISEELHLDEILNA
Protein: Transcription factor E2F7 (F8VSE7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003796}.
Interaction partners:
Sequence:
MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPKTPIKNEPIDLSKQKKFTPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAFTDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYLQQKELDLIDYKFGERKKDGDPDSQEQQLLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSSPYREEQGSGGYSLEIGSLAAVYRQKIEDNSQGKAFASKRVVPPSSSLDPVAPFPVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQNGLNGQVDVSLASAASAVESLKPALLAGQPLVYVPSASLFMLYGSLQEGPASGSGSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVEKPSK
Protein: Uncharacterized protein C2C4.05 (O14038)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Leptomycin B resistance protein pmd1
- Regulator of V-ATPase in vacuolar membrane protein 1
- ATP synthase subunit e, mitochondrial
Sequence:
MVSAWIYFTSLMLTCANIMLQMYFTVMYSDLKDDFINPIDLSRKLNWYVLPEMGFQAFSALLLLLSGAWITFLLNVPMLAWNAKMIMSNTHMHDSTTIFKDVSSRQKRSFFKLACFAVFFFVYLFLFVSRLVDE
Protein: Uncharacterized protein At3g19680 (Q9LJM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDPCSFVRIIVGNLAVRFPSSSSSSSSSSGPSVSGINPTAPNCYCKIRFKNFPREIVSVPVMFRTESESETRCSSSGNVSTVAACFSLSKAQIEASLKKPKFSVLSVEAYSRGNSDGDDGVSGASCGLATAGEKLLGRFEVSLDLKSAETKSFLAHNGWVALPSKKTKSKTGSDPELHVSVRVEPDPRFVFQFDGEPECSPQVFQVQGNTKQAVFTCKFGSRNSNSGDRNLLHSSSMMSEISSTRSCISSMNSEKEQPSKERKGWSITVHDLSGSPVAMASMVTPFVPSPGSNRVTRSSPGAWLILRPDGCTWKPWGRLEAWREAGYSDTLGYRFELFQDGIATAVSASSSISLKNGGSFVIDVTGGTSTTASTPTTSPQGSWDLGSGSSAGSRPASRPGSGSGSDFGYLLPQHPSAAAQNRGFVMSATVEGVGKRSKPEVEVGVTHVTCTEDAAAHVALAAAVDLSLDACRLFSHKLRKELRQQSQLGVV
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) (P10096)
Organism: Bos taurus (Bovine)
Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P04797}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04797}. Nucleus {ECO:0000250|UniProtKB:P04797}. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks. {ECO:0000250|UniProtKB:P04797}.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase 1
- Large ribosomal subunit protein uL13
- Fructose-bisphosphate aldolase
- Bifunctional glutamate/proline--tRNA ligase
- Glucose-6-phosphate isomerase
- L-lactate dehydrogenase A chain
- Fructose-bisphosphate aldolase
- Fructose-bisphosphate aldolase B
- Transaldolase
Sequence:
MVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLHYMVYMFQYDSTHGKFNGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYNNTLKIVSNASCTTNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDEIKKVVKQASEGPLKGILGYTEDQVVSCDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMVHMASKE
Protein: Gibberellin 20 oxidase 2 (EC 1.14.11.-) (GA 20-oxidase 2) (Gibberellin C-20 oxidase 2) (Q39111)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key oxidase enzyme in the biosynthesis of gibberellin that catalyzes the conversion of GA12 to GA9, via a three-step oxidation at C-20 of the GA skeleton, and GA25 is also formed as a minor product. GA53 is less effectively oxidized than GA12 and is only oxidized one step to GA44. Involved in the promotion of the floral transition, fertility and silique elongation, but plays only a minor role in elongation of seedling organs. Acts redundantly with GA20OX1.
Interaction partners:
- Ent-kaurenoic acid oxidase 1
- Ent-kaurenoic acid oxidase 2
- Gibberellin 3-beta-dioxygenase 1
- Gibberellin 3-beta-dioxygenase 2
- Gibberellin 3-beta-dioxygenase 4
- Gibberellin 3-beta-dioxygenase 3
- DELLA protein GAI
- DELLA protein RGA
- Gibberellin receptor GID1B
- Ent-kaur-16-ene synthase, chloroplastic
Sequence:
MAILCTTTSPAEKEHEPKQDLEKDQTSPLIFNPSLLNLQSQIPNQFIWPDEEKPSIDIPELNVPFIDLSSQDSTLEAPRVIAEACTKHGFFLVVNHGVSESLIADAHRLMESFFDMPLAGKQKAQRKPGESCGYASSFTGRFSTKLPWKETLSFQFSNDNSGSRTVQDYFSDTLGQEFEQFGKVYQDYCEAMSSLSLKIMELLGLSLGVNRDYFRGFFEENDSIMRLNHYPPCQTPDLTLGTGPHCDPSSLTILHQDHVNGLQVFVDNQWQSIRPNPKAFVVNIGDTFMALSNGIFKSCLHRAVVNRESARKSMAFFLCPKKDKVVKPPSDILEKMKTRKYPDFTWSMFLEFTQKHYRADVNTLDSFSNWVITNNNPI
Protein: Vomeronasal 2, receptor 82 (A0A3B2WD64)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MLLSWLLIVWFLQMPTFTWIIATHICPTDTKHLIHSDGTVVIGAFFPILHNSRVSKIIDWRYFPMDSDDYFGINARNYQLVLAMLFAVNEINLNSHILPNTSLGLEIYNLPAIGRNIFRTVFSWLTGLSSVIPNYTCRKESKSAATLTGLSWKTSETIWTILDLYKFPQIPHSVCSESCNPGFRKVALESKPTCCFDCTPCPDNEISNETGMDQCVHCPETHYASAEKRHCLKKTITFLSYNDPLGKGITLLSIGFSTLTALVIWVFVEHRGTPIIKANNRSLSYILLITLILCFLCPLLFIGLPNTATCIMQQYMFGLLFTVALSTVLAKTITVVMAFKITAPGRKIRWLLTSQVPKFVIPVCILIQVLLSGIWLGTSPPFIDKDYQSEHGHIIILCSKGSYIYFYCTLAYLGVMAFGSYLLAFLSRRLPDRFNESKSLAFSMLVFCSVWVMFLPVCHSTSGKVMVAMEMFSILASSASILIIVFAPKCYIVLFRPELNTLTHNRDKRHHRSKTLLKT
Protein: tRNA (guanine(6)-N2)-methyltransferase (EC 2.1.1.256) (tRNA m2G6-methyltransferase) (Q57880)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Cys).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Putative ribosomal RNA large subunit methyltransferase MJ1649
- Putative ribosomal RNA large subunit methyltransferase MJ1653
- tRNA-guanine
- Uncharacterized protein MJ0440
- tRNA
- Uncharacterized protein MJ0437
- Uncharacterized GTP-binding protein MJ1464
- tRNA pseudouridine synthase Pus10
- Tritrans,polycis-undecaprenyl-diphosphate synthase
Sequence:
MDYYVTLSPGLEKISKNEIESFGGKIKEIRENKGRIFFSGDLKLIPKINYLSRTIERMNILLHREEIPNIALDDIYKRVYNIDWTEWIKENQSFAIRPLRAGEHNFTSIDIGRVAGEAVIKSYQRDKNIRLKVNLDEPDVIVRVEVIFDELIVGIDTTGDIALDKRGYRVFNHPAHLNATIASSLVYLSDWKDDEMLLDPMCGSGTIPIEGALMKRNIPPGKFRENKYGFKFIDIFGYELLDKIKKEIVENKNIYKIIGLDKNQKYLDGAKDNAKNAEVLDTIEFICGDATKLHEKFNESDVIIANPPYGIRIGSKRSVKKLYDEFLSSAKEIMHGSSRLIVITAEDKMFKDAIAKNNFEVKEEFNVMFGGLMTRVFYLTL
Protein: Regulator of G-protein signaling 10 (RGS10) (P49806)
Organism: Rattus norvegicus (Rat)
Function: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43665}. Nucleus {ECO:0000250|UniProtKB:O43665}. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. {ECO:0000250|UniProtKB:O43665}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MFTRAVSRLSRKRPPSDIHDGDGSSSSGHQSLKSTAKWASSLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKTEDKKQMQEKAKKIYMTFLSNKASSQVNVEGQSRLTEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHRRTEEEEEDPPDAQTAAKRASRIYNT
Protein: Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) (RNA polymerase II mediator complex protein pmc5) (Q9US45)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 10
Sequence:
MASGAPPSVDLTSIQWRMPEWVQSMGGLRTENVLEYFSQSPFYSHKSNNEMLKMQSQFNALDLGDLNSQLKRLTGIQFVIIHERPPFLWVIQKQNRLNENEVKPLTVYFVCNENIYMAPNAYTLLATRMLNATYCFQKALTKIEKFPQYNPQEGYTYPKLSNDNLEVDHSNTNEPADENKNQSIENADYSFSPEDFSVVRAFMQSLHSSKEAPDVK
Protein: Uncharacterized protein (Q38AT5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEAVVYEIEQDPDTRLHRLRNAMLAFVSVPMASPPAVALLVSLSLDEPPGSSRKQQDRATTKATAVETQLRSACDDRAVLLKWLRAEMNIVLDIPVAASFEPSGAEQLSVLSTWQQDQHRSPLRKADIVLLSLRNVAPLWDNHETSSSLLGRQRDVCAPHLGLFLLAHQSLLLDVTCCVGGGKLELLSPAAFSPLRARHIAKGRTAAVAFYGCWLSLAATPSGFHILQKRLQSLNEHVLSAMQLPLCCSYGGKVGNLQHNLSTVPSPAGAARPREVHTVSAPLLPTRPLRDIFSLLGFLLACPHVDYYSEATKFCTRVATRRKTALVTENKCFSGCATHSEEVVKRYDRKRMRGVIRASLSMRSKRQQHSSAPDKKQTFTQLITSEEPLWYEDCGS
Protein: Uncharacterized protein (Q4GYH6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFHLPRAVQCALIASASPSSLRYATRCIGTSTDGPGGTRRGSAPTAGGRRGRPSAHMRNEAAISTSGGAAASRSASRQGAHIDYAAVSDGRTTSRPGVSSFTRAATTTLGTVGGGGGVTGSSVSQLSMQNVMEANQNRVLSRQPLRRTASQTAAGGLQATPSASGVQTAPMAAPATQRQQPQQQNRQVARTSTSIPVQPLPTLSSVRPPATKSPASSRPAIATSPSGTARSLRTPRTPRGTKAAAKPSSAAAAVNISAATTAGARAAAAAIVARASPTRVAAAGAASGTTTTTTTTAAGVRARGSVPSPDTRAALEKAMQAVNAAVKSATPAGTTVPIAAMATRPISRAAVEEAMRAVDAAVTATRGATTAANVVPPRSRVSKSAPSPRTPWGTRPAAKATTQVPASAPAVTPTAAAQGRVRSAATTPTATGKTSPARARRRASPRGAGATAAEASPVARPVPAAVNTTKVSETAATEAAVARALAAAAAAAAPSRARTAPKAAGSATTPAKKHVTVVTPTRTPRAAAATPQAVTVVTPTRSAVATTPVKPQVAVVVSPTRATRPTSPPAKPQAAVGTPARAASAVAPANSQMMIVTPTRAARSTSVPSKPGVTVVTPKRAPRAASTPAKSQVTVVTPTRSPRAGAAPVASPAVEKAPVPAAASVGTTETVATPTPRRRSAESGANTPKGKRSASGKRGAVDATEENSKASRVTTPTSTVATTPPRAEVLRDHSSQATTTGGGVANPFRGLHNHITRSYRLDQLQAAMKIHDLLLGRQEVKSGAFSFIRFACGPKFINDHREIVGPDAGGGVGVSGADEKKGSSRNSSRTNGSEDCPLVIAERLLSFPPHMHHFHTVCGRENVPCDFFADIDLPNETPAGGEKALLEVLNYLDVRLEAIGFSQPSFLVLTNEVPSAGKVSYHLHARSMGTQSDSGGAAAAGSMGSSGGSGGAGVDEHSAGGDVKQGRGRSAEGGKSRASHGKIVAFQDYRVVKLLADEVNTTLGRTVIDEQCYRVNGMLRCAYSSKITVPQGMPLSSNTAGGYHRGKRLVPLLKAKDTALQKRLDDMAAHLCTLSDAQILERTFCIRTAPVKERRVTENEDVDNAQKLLRARSDYLRSFKLIRAKNIVGAQNAKPVEYDAYGNVVSRYLTESAKWHRFKTAVEKLHRLPPRAAECYDIWVRVGLALHNFSNEDHVFEEWVRFSLKCPQKYSRETCRRKWQQFDRNPDALNWRRGFNYLNSTVWRSVPGC
Protein: Putative eukaryotic translation initiation factor 4 gamma (Q1MSJ3)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MEKDHQPVISLRPGGGGGGPRPGRLFSPAFAAAASGSGDLLRSHVGGASKIGDPNFEVRERVRYTRDQLLELREIVDIPEAILRIKQEIDIELHGEDQIWGRPESDVQVQTQTQAQPHNRYGETDNRDWRARTVQPPAANEEKSWDNIREAKAAHASSGRQQEQVNRQDQLNHQFASKAQVGPTPALIKAEVPWSARRGNLSEKDRVLKTVKGILNKLTPEKFDLLKGQLMESGITTADILKDVISLIFEKAVFEPTFCPMYAQLCSDLNEKLPSFPSEEPGGKEITFKRVLLNNCQEAFEGAESLRAKIAKLTGPDQEMERRDKERIVKLRTLGNIRLIGELLKQKMVPEKIVHHIVQELLGSGPDKKACPEEENVEAICQFFNTIGKQLDENPKSRRINDTYFIQMKELTTNLQLAPRLRFMVRDVVDLRSNNWVPRREEIKAKTISEIHDEAIKTLGLRPGATGLTRNGRNAPGGPLSPGGFPMNRPGTGGMMPGMPGTPGMPGSRKMPGMPGLDNDNWEVPRSKSMPRGDSLRNQGPLLNKPSSINKPSSINSRLLPHGSGALIGKSALLGSGGPPSRPSSLMASPTHTPAQTAPSPKPVSAAPAVVPVTDKAAGSSHEMPAAVQKKTVSLLEEYFGIRILDEAQQCIEELQCPEYYSEIVKEAINLALDKGPNFIDPLVRLLEHLHTKKIFKTEDLKTGCLLYAALLEDIGIDLPLAPALFGEVVARLSLSCSLSFEVVEEILKAVEDTYFRKGIFDAVMKTMGGNSSGQAILSSHAVVIDACNKLLK
Protein: Probable WRKY transcription factor 30 (WRKY DNA-binding protein 30) (Q9FL62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
Interaction partners:
- Senescence-induced receptor-like serine/threonine-protein kinase
- Cytochrome P450 71A12
- Transcription factor MYB51
- Transmembrane protein
- At5g12930
Sequence:
MEKNHSSGEWEKMKNEINELMIEGRDYAHQFGSASSQETREHLAKKILQSYHKSLTIMNYSGELDQVSQGGGSPKSDDSDQEPLVIKSSKKSMPRWSSKVRIAPGAGVDRTLDDGFSWRKYGQKDILGAKFPRGYYRCTYRKSQGCEATKQVQRSDENQMLLEISYRGIHSCSQAANVGTTMPIQNLEPNQTQEHGNLDMVKESVDNYNHQAHLHHNLHYPLSSTPNLENNNAYMLQMRDQNIEYFGSTSFSSDLGTSINYNFPASGSASHSASNSPSTVPLESPFESYDPNHPYGGFGGFYS
Protein: Large ribosomal subunit protein uL11c (50S ribosomal protein L11, chloroplastic) (CL11) (Q9MAP3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein bL28c
- Large ribosomal subunit protein bL27c
- Small ribosomal subunit protein uS9c
- Large ribosomal subunit protein bL9c
- Large ribosomal subunit protein bL17c
- Large ribosomal subunit protein bL21c
- Large ribosomal subunit protein uL15c
- Large ribosomal subunit protein uL13c
- Large ribosomal subunit protein uL4c
Sequence:
MASSSLSTLCSSTSSSLHPNSKLSHSLSAKLSSKANVSVQFLGKKQSPLLSSTPRFLTVIAMAPPKPGGKAKKVVGVIKLALEAGKATPAPPVGPALGSKGVNIMAFCKDYNARTADKAGYIIPVEITVFDDKSFTFILKTPPASVLLLKAAGVEKGSKDPQQDKVGVITIDQLRTIAAEKLPDLNCTTIESAMRIIAGTAANMGIDIDPPILEPKKKAVLL
Protein: Monothiol glutaredoxin-S3 (AtGrxS3) (Protein ROXY 11) (O23421)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MENLQKMISEKSVVIFSKNSCCMSHTIKTLFLDLGVNPTIYELDEISRGKEIEHALAQLGCSPTVPVVFIGGQLVGGANQVMSLHLNRSLVPMLKRAGALWL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4I7B6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDKYELVKDIGAGNFGVARLMKVKNSKELVAMKYIERGPKIDENVAREIINHRSLRHPNIIRFKEVVLTPTHLAIAMEYAAGGELFERICSAGRFSEDEEEGNKRKHARYFFQQLISGVSYCHAMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLSRREYDGKMADVWSCGVTLYVMLVGAYPFEDQEDPKNFRKTIQKIMAVQYKIPDYVHISQDCKNLLSRIFVANSLKRITIAEIKKHSWFLKNLPRELTETAQAAYFKKENPTFSLQTVEEIMKIVADAKTPPPVSRSIGGFGWGGNGDADGKEEDAEDVEEEEEEVEEEEDDEDEYDKTVKEVHASGEVRIS
Protein: BHLH transcription factor PTF1-like protein (Os09g0417400 protein) (Q6EPZ6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAAAAAGQISLDDLRNGGGVAANAGGGGGVHDDFLDQMLSSLPPSAWPDLAAGKAAEDDAEGMHHHHHQQQQQFGGPYDESAMLASRLRQHQISGGGGGGGGGAAAVKQMVLQQLADLRQGHHMMLQGLGGRSPAGGGGGGGDGGLLLPLTLGSGGSGGDVQALLKAAAANSAGGGDAGGVYGGGFAGSLHQQQQHFQPHPQTAPTIPTQSFGGGGGGGGGGTASGGGAAQPQAGAAGGGAPAPPRQRVRARRGQATDPHSIAERLRRERIAERMKALQELVPNANKLMQTDKASMLDEIIDYVKFLQLQVKASTYTKLLIHVLSMSRLGGAAAVAPLVADMSSEGRGGGAANGGAPAAAGSDSLTVTEQQVAKLMEEDMGTAMQYLQGKGLCLMPISLASAISSATCHLRPPVVAAAQQFPAGLGAAAAAAHHHQLSAAAAAAAMRGHLPGLNADGSVPASPSMSVLTAQSAMANGGGGAADGEGSQLKDAASVSKP