Protein: Protein eyes shut homolog (B8JI71)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:30052645}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A0A2K5V015}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000250|UniProtKB:A0A2K5V015}. Note=Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822). {ECO:0000250|UniProtKB:A0A2K5V015, ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:30052645}.
Interaction partners:
- Recombination signal-binding protein for immunoglobulin kappa J region b
- Usher syndrome 2A
- histone acetyltransferase
- SNW domain-containing protein 1
- non-specific serine/threonine protein kinase
- Transmembrane p24-trafficking protein 2.
- Ceramide kinase-like
- Si:dkey-44k1.5.
Sequence:
MRNPKLAIIVFLLSCVIYGPVYSQVTCRRATSREWHTQPKNISVRWTLMENTCSSLTQCWSSFAETNGHFWTTGPYHFPQLCPLELQLGDLLFVSADGTLEQHGVQLIKVSKEEFDKCAILEPRKEQLVFASSINGTLQVESKWLMSGLNYFTIINRGSSHLCRFGLRIAVLVKPQLCQSSPLLRLCSGKGECRTTLKDDSFTCRCHKHFSGRYCENVDGCYEQPCLNGGTCLSEGSAYTDLPPYTCLCPAPFTGVNCSEIIGNQNCSKWCKEGACLKVSSTSYRCECFTGYTGTYCERKRLFCDSNPCRNDGRCEETANGYVCTCPGGFTGLNCETTAEADSYCKSSGCQLDEACATDKLNATCICVDPECLEQAEVCGTLPCLNGGICVVPNGQYHCRCRQGFSGKNCEEIIDFCKLLNINCLNEGLCLNRVGGYNCLCAPGWTGEFCQYLENACLAYPNRCLNGATCISMSQTTAPPHYMCTCLPGYTGPYCEAEVNECDSSPCQHQGTCTDFVGYYKCTCPSGYTGIDCEIDINSCWLPNATCPPETLCVDLPGDQLFKCHTPCPHYLQPCANGGHCVLHNITSYSCVCAPGWTGATCLVNINECVQHRCQNRATCVDEVGGYSCLCGHGYTGVHCELDFCSGHQCSEHAVCVDQQHNYTCRCMLGYEGTLCELETDECKSAPCTNNATCIDLVAGYQCLCAPGFKGRTCSESMNECWSRPCNNGGSCIDLVNDYICNCPLGFTGHDCSMPATGCTSNPCNTKGTSMCEEQQDGFKCVCHHGYTGLFCETSINHCVEGLCHHGSECVDLTKGFMCECLPGLRGRLCEVNIDDCLDKPCGALSICKDGINAYDCFCAPGFVGNNCEIEVNECLSQPCQNGASCSDELNSFSCLCLAGTTGSLCEINIDECQSSPCMNNGTCLDLSDGFKCICPSGFSGPECSMDINECVSYPCKNGGSCIDQPGNYYCRCLAPFKGLNCELLPCEAVNPCDNGAECVEEADLVLFPLGFQCRCRKGFTGPRCEVNIDECSSNPCLNGFCYDAVDGFYCLCNPGYAGVRCEQHINDCASNMCENNSTCVDLHLSYNCLCLPGWEGEYCQRETNECLSNPCKNNATCTDLLNAYRCVCPQGWTGLDCDEDVKECSSSPCLNGAHCVESDTPGEFSCTCPPFFTGPLCEQPYDPCELQRNPCLHNSTCRAQSDGTALCVCPVGFEGTRCEIDSDDCVSRPCQNRGICVDGVNSYSCFCEPGFSGLHCEEDINECASNPCQNQAVCQDLVNGFQCSCVPGYFGPHCNLDVNECDSSPCLHESVCINKPGGFACVCSAGFSGKWCELNVDECKSNPCRNNGSCIDGLNGYQCVCSRGFMGDHCERNTDECSSGPCVHGSCLDEIDAFSCQCEVGWTGHRCQININECEAHPCLNGGSCVDLLDKYACICADGFTGKNCDIDQNVCLQTSLNFSLCFNGGTCVDGPGVNFTCSCRPGFMGDFCEVEMNECCSEPCFNGAICQDLINGYQCHCRPGWTGLHCEDDINECLLQPCNQGMCIQNEPGHGYTCFCRPGFVGENCEYNYDDCLIQSCPETFSCKDGINNVSCVPVKTDTSSLPPISVVSWRSTDISTELQPTFAPVENLQHTEQPADASFGGYSGNSFLEFGGFEVAVPISVTVRFQTESMYGTLLYSASAKRSVFFIKLYISNGILQYDFLCNQKQGVQRINTAQWVADGNEHVVIFRQCLFPCVAEVTVSGVRTVRSAPGNYTSALRLQRTDHVFIGGLPRHRSPYKEAEPFHNYTGCIEIIEINKLRRFHMDHAIARNNVDNCRSQWHHEPPTSSTHSPTLLITVETPPGEWVRVLSPTQPAPVCPQGICLNGGTCRPVSLPSGASSFFCDCPLHFTGRLCEQDITVFSPRFDGNSFLELPSLTSLFQSDTYFPSRSSEDKRILYLTMKSRTPHGSLLYCREQDLGERFLHVFLQNARAVARLGCGAAHILTAVAAQNIRIDSLVAITVRYALPSQNNGQLCFIEIAADNGTANQQQKYMDEPVSEVVFGPTFLGGFPSVLELHHNSGNVSGFIGCIRELQMGSKELYVVGEAIRGQNIQNCDAAVCQHQPCRNGGTCISDAESWFCACPSLYSGKLCQFTACERNPCARGATCVPQTQLEAACLCPYGRQGLLCDEAINITRPKFSGLDEFGYSSYVAYPSIPSTGHFYEFHLKLTFANNASALRNNLILFSGQKGQGLSGDDFFALGVRNGRIVHKYNLGSGLATIISDRLNPRINIHTVHFGRYLKTGWLKVNGQKRRTGTSPGPLMGLNTFSQLYIGGYEEYTPELLPPGSRFQNSFQGCIFDMLFRTRQDGKFHALGGPDIRPLSGRNVGQCGVNPCSLVFCHNGGTCVDSGSSVYCQCVFGWKGALCSEKVSFCDAEHIPPPFCARGSTCVPLSDGYTCQCPLGSAGLHCQQAITISDPFFSGNQSSWMSFPPINIRHRTHVQLQFQTLSPEGILFYTAQHLSTHSGDFLSISLSAGFLQLRYNLGNQTIVLQSPKELDVTGVRWHTVKAGREGNSGFLIVDGESVTRNSSEGSTTLDVGANIFIGGISSLNTVSIDAVEKELVGFTGGIREVVVNGQELELTETGALDGANVGDWDGTACGYKVCKNGGHCHPSGDFSFTCICPSLWTGSRCQQSIQCLNNLCQHNSVCIHNSTSASYSCMCSLGWTGTHCDREVTLKTIRFIGNSYLKYKDPKYNSRNLMHTEVSLNFSTSAGDGLIFWMGKAESEDDDHLAVGLQDGYLKISVNLGERTALPLVYQNSFCCNYWNYLSITHNRTLIQVYVNEERVIFEDIDPFEQYVAVNYGGVIYLGGFELNRDVASVTSGVFTKGFEGSIKDVFLYQDTKQLQFLQTCEGFNVYQGEE