wanglab/gogpt-training-data huggingface dataset:
Protein: Ethylene-responsive transcription factor CRF2 (Protein CYTOKININ RESPONSE FACTOR 2) (Q9SUQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16832061}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366, ECO:0000269|PubMed:16832061}. Note=Relocalization from the cytoplasm into the nucleus is induced by cytokinins.
Interaction partners:
- Two-component response regulator ARR7
- Two-component response regulator ARR12
- Two-component response regulator ARR1
- Histidine kinase 4
- Two-component response regulator ARR10
- Histidine kinase 2
- Histidine kinase 3
Sequence:
MEAEKKMVLPRIKFTEHKTNTTTIVSELTNTHQTRILRISVTDPDATDSSSDDEEEEHQRFVSKRRRVKKFVNEVYLDSGAVVTGSCGQMESKKRQKRAVKSESTVSPVVSATTTTTGEKKFRGVRQRPWGKWAAEIRDPLKRVRLWLGTYNTAEEAAMVYDNAAIQLRGPDALTNFSVTPTTATEKKAPPPSPVKKKKKKNNKSKKSVTASSSISRSSSNDCLCSPVSVLRSPFAVDEFSGISSSPVAAVVVKEEPSMTTVSETFSDFSAPLFSDDDVFDFRSSVVPDYLGGDLFGEDLFTADMCTDMNFGFDFGSGLSSWHMEDHFQDIGDLFGSDPLLAV
Protein: Zinc finger protein squeeze (Q9VDZ3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein dimmed
- Neuropeptide-like 1
- NGFI-A-binding protein homolog
- FMRFamide-related peptides
Sequence:
MAELPTAPNGVPSGDYLHRSIDQLRSLGHLTTAQLVHDYKPFNISEFRQNVAERLDYSLKNGLVQHQQQMVMEQQPHPDQQQQQHLHHPQQQQHPPQLKVSYSAPNSPPTPHEQQEQKYDPNRSPPRQQMSSASGSGSNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQKHLQKHAEKAEKQQHRHTAQVAAHQQHVPASGIGLNLQRQAMNDVNAAYWAKMGADSAAASLAEAIQQQLPQAGGQPYGNFASLQQQHQQQQQELLHHQRLADTPGHSHSPHEEAAGEDLVLRQSTPQHHLQQQQQQQQQQQAQQQQQAQHQPSPGPGNSAFTPLSATVAPPPHLQQHRGPPGSAAAYLYQQNAAAAAAAFPTQLISLHQIRNYAHQPGAAGLIAGDHLALGLSAVNAAKEKAQ
Protein: Glycosaminoglycan xylosylkinase homolog (EC 2.7.1.-) (Xylose kinase homolog) (Q95T10)
Organism: Drosophila melanogaster (Fruit fly)
Function: Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:22900076}. Endoplasmic reticulum {ECO:0000269|PubMed:22900076}.
Interaction partners:
- Extracellular serine/threonine protein kinase four-jointed
- Alpha/beta-tubulin-N-acetyltransferase 9
- NADPH--cytochrome P450 reductase
Sequence:
MNKRSVIIAGIVASLLGLALGANFYFMYYLSAEEGHLASVRALENMIRHKMRHLKPNYLNRNPRFFMFRNKLLKNYKAAPYENASVLWDIANWWPHENEVYPLYDSSMGQLLETLRREPITRVSNLGRGTQLKLLVRLSHQQKVIFKPQWYPREEVIDGMIYSGKDRHTAEVYAFYLGAVLDFRWTPIVVGRVVNLKKEIYAKGDPELQQTINIETDEDGREKYCLFGKCHYCNEEETVCGDERHNIEGVLIYIVPGTLAKRRSPWQRTYKDDKRAPWEDDMTYCKSLKNKMETIRLLDLIDASIFDYLIQNGDRHHYETREERVVLIDNGKAFGNPNKDHLDILAPLYQCCLLRKSTWDRLQVFSGGVLTEIIDRLSKQDALYPLITDKHKKGVERRLLVVYAVVEHCMDIEGDKMFKTL
Protein: Long-chain-fatty-acid--CoA ligase (Q18916)
Organism: Caenorhabditis elegans
Interaction partners:
- Acyltransferase
- long-chain-fatty-acid--CoA ligase
- Acyltransferase
- Acyltransferase
- BBSome complex member bbs-7
- O-acyltransferase
- Protein pthb1 homolog
- BBSome complex member BBS1
- Tetratricopeptide repeat protein 8
Sequence:
MREMPDSPKFALVTFVVYAVVLYNVNSVFWKFVFIGYVVFRLLRTDFGRRALATLPRDFAGLKLLISVKSTIRGLFKKDRPIHEIFLNQVKQHPNKVAIIEIESGRQLTYQELNALANQYANLYVSEGYKMGDVVALFMENSIDFFAIWLGLSKIGVVSAFINSNLKLEPLAHSINVSKCKSCITNINLLPMFKAAREKNLISDEIHVFLAGTQVDGRHRSLQQDLHLFSEDEPPVIDGLNFRSVLCYIYTSGTTGNPKPAVIKHFRYFWIAMGAGKAFGINKSDVVYITMPMYHSAAGIMGIGSLIAFGSTAVIRKKFSASNFWKDCVKYNVTATQYIGEICRYLLAANPCPEEKQHNVRLMWGNGLRGQIWKEFVGRFGIKKIGELYGSTEGNSNIVNVDNHVGACGFMPIYPHIGSLYPVRLIKVDRATGELERDKNGLCVPCVPGETGEMVGVIKEKDILLKFEGYVSEGDTAKKIYRDVFKHGDKVFASGDILHWDDLGYLYFVDRCGDTFRWKGENVSTTEVEGILQPVMDVEDATVYGVTVGKMEGRAGMAGIVVKDGTDVEKFIADITSRLTENLASYAIPVFIRLCKEVDRTGTFKLKKTDLQKQGYDLVACKGDPIYYWSAAEKSYKPLTDKMQQDIDTGVYDRI
Protein: LYR motif-containing protein 2 (Q388V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MLHCSQWLRHRVNDRGGTAHNFAFDALTKVYRDAVYGNNLSHSGNSVTPGHSAAAASTASPTSPAEMQHQLPRGPRLSGVQREILQLYRDLLKETRRMRDLRTQANLRRFIRSEFDKSANISRKYITRIEWQMNYGKNKLDELRHMSPDMRFSLVH
Protein: Phospholipase A I-like protein (F4HX14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSWGLGWKRSSESFRLSLSYGADDLNDDPIQSPSASPFGSPTSMSSTCSSPSAVEDPELGFRIDLDWTAGDSEDQVALRLESQLMVALPAPHDTVVVELKGIGDDDEGGLENVGLEMRVEKRREPLRAVTLMKAVGSGQQYDGVGVLTRLMRSDMMPAAIPAPAIDVASSCGVHWKTVTSLSLSGCGLLVMPVEVTELPLLEKLCLEHNKLSVLPPEIGKLKNLKILRVDNNMLISVPVELRQCVGLVELSLEHNKLVRPLLDFRAMAGLRILRLFGNPLEFLPEILPLHQLRHLSLVNIRIVSDENLRSVNVQIETENTSYFGASRHKLSAFSPLIFRSSSCHHPLLASTLVKIMQDEGNRSVIGKDENAVRQLISMITSDNQHVVEQACVALSSLARDVGVAMQLMKCDIMKPTETVLKSSSPDEVISVLQVVVTLAFVSDSVSQKMLTKDMLKALKSLCAHKNPEVQRQALLAVGNLAFCLENRRILITSESLRELLMRLIVTPEPRVNKAAARALAILGENEILRRSIKGRQVPKQGLRILTMDGGGMKGLATVQILKEIEKGSGKPIHELFDLICGTSTGGMLAIALGVKLMTLEQCEEIYKNLGKLVFAESVPKDNEAASWREKLDQLYKSSSQSFRVVIHGSKHSANEFERLLKEMCADEDGDLLIESAVKNVPKVFVVSTLVSVMPAQPFIFRNYQYPVGTPEMSYAFSDHSGGSTLTSSTASDQAGYYKQSAFMGSCKHQVWQAIRASSAAPYYLDDFSVDSYRWQDGAIVANNPTIFAIREAQLLWPDTKIDCLVSIGSGSVPTRVRKGGWRYLDTGQVLIESACSVERVEEALSTLLPMLPEIQYFRFNPVDDRCGMELDETDPAIWLKLEAAIEEFIQSNPQVFKNVCERLTLPFLNDEKWCDNLKPRFMNGKLPNSRVESSPSLGWRRNVLLMEAQHSPDSGRVKYHARALESFCSNNGIKLSSLHTTATPGCQKPSPGTAFPTPFTSPLITGSLPPSPLLFTPELGPQKFNRIDMVPPLSLDGGHVGKTVMSPPSSPPRQRQLYLPLRQMHEKLQNLPQVGILHLSLQNDSNGSILSWQNDVFVVAEPGDLADKFLQSVKVSILSVMQSNRRKAASVLSNICSISDLVRSKKCFQVGNIIHRYIGRQTLVMEDDQEIASFMFRRTVPSAHLTPDDIRWMVMLLLDFCIPKIAERLAFAHIYLLSHSLKG
Protein: Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) (Q9Y2H9)
Organism: Homo sapiens (Human)
Function: Microtubule-associated protein essential for correct brain development. Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9R1L5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R1L5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9R1L5}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9R1L5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1L5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1L5}. Note=Also localized in the soma of neurons. Observed as punctate clusters in the processes of interneurons and along the cell body periphery. Colocalizes with syntrophins at the cell membrane. {ECO:0000250|UniProtKB:Q9R1L5}.
Interaction partners:
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Beta-2-syntrophin
Sequence:
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGLGAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKKGVSSPAPPGP
Protein: SH2 domain-containing protein (G5ECF0)
Organism: Caenorhabditis elegans
Interaction partners:
- small monomeric GTPase
- Ras-related protein ced-10
Sequence:
MITSLPSTSTSARSTSNVSNSDIPVPKPRRLLVTSKTPVPSPRKSLFKSKSDEREYNEEVEVRLRKHVGLIRRDTYKPIMMEREKLQRILEDAVEPDSKLPKIRPATFPSGSSSCNSNYLEPIIDISLYDNVEEIGTSCSSASDSMSARAIAAARSRGGGAAPSSNGNERPLSAYEESDEAVRQRKNRRASVAVMPMMELEYRDQVVAGSIKSATMNRRKSDGNPAGRAFSPDFGAIRVQVEDITSVPGSMMTEDDDDVDDEKHGLNGGRSFDNGGETSTETITDVALNGSLLMASGRVSEWAVPIEYASSPIAQELSQSEVEERPRPPIPAMYINTSSSTTTAPTADRGEESVYSDFVLKRNSSTSSMSGKSVTLLEQIIRTHAVWYLPHMGRPEVLHLLRRMEPGNFIVRASTRENCMALSVRLAPGAHVEIDHYIIEKLVVPLKPTTSKEPAAPTTAKAVRLEGSPLTFRSLPLLIEHYCVNEDELEHRLQLPSAIRACTTTKQLLSIAMMEQEFWSCEMSLSRKAAPSTSSSRNSISSSLRSSSNNNNNSSNTMPRCHGTAESDASTWFMDRPKVVVDDESIYDEVEPRMMGSKTGVGGGGYYAVHDTKSSSNTLNNNIPRRSSAMLLSPEMAMNSEQQKNSKKRRSSSRSSSNSRFATVCVGGFDGWNGGTSSSKQVDTDETDSGLSTHSPPSKHDRLDDVHISRSDRRSQSVRSHKSVTASPKLGHSTSSTLSRPRSFLRSLLSFGSSNKEHKRKESLDIDSTPRLASCEYFTPWDTNGTNMQVRTSRSAFDITNPPARGFFGSGSPKKRNGIMPSTSSVYQKNASSSSSNMFDDDNYTRGWKEAAYAETSPHHNNNNHLTDAAMRTFKPPNYDDVAGSSATSSPSSRSRPLAMRRERSDIGVISNGMNLGVKSNAQRLAYHNESSPGPAHAIGRVPMTPPANAGDPQVQQNCVEELRRKRLQSTNEMLSPKELPSSKHPHGEVHSAHASPQIAMRRRNGFPSPSASHNGFNRNNAFAAIDRNRGSDHRLSVPNLIAATDPLVPGSVGQSAKALRERLGGRTTDGDLMVINEGLVTPVVRRKTFAPATTTTKTTATAATSMDELGGEVMRRREALEAAMNEKRRHPSDSLSSGSSDHSSLGRRKTSTSSQAHQLGTTESELVWRRAKNNNPPSSTVAPSTSSKSGGGTSHWSAINHEIKNRQQKIAKVLPTPQPRGHHHNRTMSIVGGPPSVISECRRSSDYAQLCDFASSTDKNGIHLDVHSKIEDDAVSVAGTVFNEPWDSNVWENLLDLAHHGDESTMGLKVSEPIQEEDSDSDRTAGGDSTCQMDSDEDDDDDDEDEMIRWQTEKMMRRPLPSDRVTVKAWEQDSDAGSSKFNTLESRSKNGSIAGSTLRRQPEGSFSIRSLPRALSRFSHTLGMNGMSAAASFGSIDDLPTTLPSMSPLLSGRVSRAQLPRSSSTDEKIGRAVQNYVEELAQVKEGDNACFGLTLRQFVACTKDTKETDPAVVIRNVRQFINGMKNYLVKHGEGDLHHIIDEESSRLNSNQILNIDAVLEAVLHKLLLREVKPLLYHVMIKEHSKAGALQLISQNQGVVRKMNLTELGFSNPESLVTPSSSIMEQVKLLMRKMQNHYSPMKKLENLMKAVGLVLGCQVNNGNENENPTDPMSCGYRGLPPGDDLVRWFVYILSRTSTVGCEVEAWYMWELLPQPIVTQSDASYYLTSLWSAVHVLKSTESIRRLCENDQRVIVSHDSSRHLCSSPLLSTATLTRGTSAGIPQVISAATCDAFVKIAVPDEAVGCVRYATFPGVPMLTTSKLSRLVAHQQGITNPEEHGLYLIAEGFESCLSPSECPVLVHEQLKKDKKPHMFAYKRHEAKIAWPRAAIC
Protein: Rhoptry-associated leucine zipper-like protein 1 (Q8IBN1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNFFFFFIIVYCFISSFYLIKSSSNDKNKINKNNMPLQRGASNLKDINIHNVEKKSNMESVNNNINNTTCSKNLNANKVPNVAHTGVNKKGETKNEEVEKEENENEEIEKEEIENEENQQNEEDENEENQQNEEDENEENQQMNVNVDVSAEKKNKELPEEKKELQKNSEKNINKEVIKDSNKDNTFNFHKNINTSFNKNKNIYNNNNNNNNNNKTFIEKKEEAIDMKKTHCSNNNKMCKYNNMNNHMSTNKNNNQIFEESKQNVNKPIYNLKSLGNNTFKNDEKYNENDYKNNHDDDKKKYTDDSNEENIYEERNQKILLIHLLKNIKELLNRQRQNFNNFLSFLSENYQSYEKFYKSQKYQNGKNYIDKLDQQGELKNVSVVTHSFLDMSKAANGKKDKNGVFVKLMNDQNDDGDDTKDGDDTKDEDDHKNEDDHKNEDDHKNEDDHKNEDDHKNGDDNKNGDDHKNGDDNKNGDDDNGKKSHDISDIKNIIDTILQSDDITDEQKKYLEIIKKILDLEEDVLNKEKEQLQLNKNIIEVLMGKSDELRNIAVNLKNGNGDNESSQRVDLAQNIVSNLLNFSVQLKNTGNIVYNNIQGQGELLQSIEKNIDKAENDLKKSTSVNTTFTPKNVPNTEQNDQETQTDDDINDSDIDENNNTNDKNNCHMYKKNNCHMYKKNNCKKYFLNSHYNNYLCKKQKKYNKNDMGNKQKDNKKFKLNESMKNHFYNIFVKETVMLKKLYKVLFELF
Protein: Ribosome biogenesis protein BRX1 homolog 1 (AtBRX1-1) (Brix domain-containing protein 2) (Q9LE16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in pre-rRNA processing and required for biogenesis of the large (60S) ribosomal subunit. Required for proper development.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:25605960}. Note=Associates with 60S pre-ribosomes. {ECO:0000269|PubMed:25605960}.
Interaction partners:
- Probable rRNA-processing protein EBP2 homolog
- AT5g04600/T32M21_200
- AT5g20600/F7C8_190
- 60S ribosome subunit biogenesis protein NIP7 homolog
- At4g01560
- Nucleolar complex-associated protein 3
- Ribosome biogenesis protein WDR12 homolog
- Ribosome biogenesis protein BOP1 homolog
- Probable ribosome biogenesis protein RLP24
- Ribosome production factor 2 homolog
Sequence:
MGRKRKHSETVTAAPVKDSAPERPQRTLLGWKDKKEDAENSKPAYASVFRNKEKVLVTCSRRINFRYRHLMLNMVSLLPHCKKDSKVEAKSSRGATLNELIELKGSSSCLFFECRKHKDLYMWMVKSPGGPSVKFLVNAVHTMEELKLTGNHLKGSRPLLTFSSNFENDAHWKLLKEMLTQIFGIPEGHRKSKPYHDHVFVFSIVDDHIWFRNYQISVPHNESDKIARGDLDKMTLIEVGPRFCLNPIKIFGGSFGGTTLYENPFYVSPNQIRALEKRNKAGKFAKKIKAKTRRKMHELSNPLEPDEFTDMWNDE
Protein: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) (P9WHQ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- tRNA
- Adenine phosphoribosyltransferase
- Inosine-5'-monophosphate dehydrogenase
- Adenylosuccinate synthetase
- Hydrolase
- Purine nucleoside phosphorylase
- GMP synthase
- Carboxypeptidase Rv3627c
- Probable nucleoside hydrolase IunH
- Guanylate kinase
Sequence:
MHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
Protein: Semaphorin-4B (Semaphorin-C) (Sema C) (Q62179)
Organism: Mus musculus (Mouse)
Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Plexin-B2
- Plexin-B1
- Plexin-B3
- Discoidin, CUB and LCCL domain-containing protein 2
- PDZ domain-containing protein GIPC1
- Disks large homolog 4
Sequence:
MGRASRSAVLRRALLLLLLLLLLRTTTTRALGPRISVPLGSEERLIRKFEAENISNYTALLLSQDGKTLYVGAREALFALNSNLSFLPGGEYQELLWSADADRKQQCSFKGKDPKRDCQNYIKILLPLNSSHLLTCGTAAFSPLCAYIHIASFTLAQDEAGNVILEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSSRPTKTESSLNWLQDPAFVASAYVPESLGSPIGDDDKIYFFFSETGQEFEFFENTIVSRVARVCKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLNPNPQDWRKTLFYGVFTSQWHRGTTEGSAICVFTMNDVQKAFDGLYKKVNRETQQWYTETHQVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVRSRLLLLQPRARYQRVAVHRVPGLHSTYDVLFLGTGDGRLHKAVTLSSRVHIIEELQIFPQGQPVQNLLLDSHGGLLYASSHSGVVQVPVANCSLYPTCGDCLLARDPYCAWTGSACRLASLYQPDLASRPWTQDIEGASVKELCKNSSYKARFLVPGKPCKQVQIQPNTVNTLACPLLSNLATRLWVHNGAPVNASASCRVLPTGDLLLVGSQQGLGVFQCWSIEEGFQQLVASYCPEVMEEGVMDQKNQRDGTPVIINTSRVSAPAGGRASWGADKSYWNEFLVMCTLFVFAMVLLFLFFLYRHRDGMKLFLKQGECASVHPKTRPIVLPPETRPLNGVGPPSTPLDHRGYQALSDSSPGPRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV
Protein: Tubulin alpha-1 chain (EC 3.6.5.-) (P06603)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin beta chain
- Tubulin beta-2 chain
- Tubulin beta chain
- Tubulin beta-3 chain
- beta-Tubulin at 65B
- Tubulin alpha-3 chain
- Serine/threonine-protein kinase CG17528
- non-specific serine/threonine protein kinase
- Echinoderm microtubule-associated protein-like CG42247
- Dynein heavy chain, cytoplasmic
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEEY
Protein: Chaperone protein DnaJ, putative (Q585V4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Chaperone protein DNAJ, putative
- Chaperone protein DNAJ, putative
- Stress-induced protein sti1, putative
- ATP-dependent Clp protease subunit, heat shock protein 100
- Heat shock protein 70
- Uncharacterized protein
Sequence:
MQARMVKETKYYDALGVPPNASEDDIKRAYRKLALKYHPDKNKEPGANEKFKEVSVAYECLSDVEKRRRYDQFGEKGVESEGVGIDPSDIFSSFFGGRRARGEAKPKDIVHQQPVPLETFYNGKTIKLAIIRDRLCDSCNGSGSKDPKVSSRCVECDGRGVKIITRSIGPGFVQQMQVACPRCGGKGTDIKEEHKCQSCRGQQIVKDKKVFDVVVEKGMQHGDSVTFQGEGDQIPGVRLSGDIIIILDEKPHPVFTRKGDHLLIHHKISLAEALTGFTMNIKHLDERAISIRSTNVIDPQKLWSVSREGMPIPGTGGTERGDLVIKFDVVYPSAQSLSGDGIEPLRRILGYPKQEEPAPEATEHTLAVTYVDLDREARRRRTAANDDDDDAGQHVHTGATCTQQ
Protein: Acyl-CoA synthetase (EC 6.2.1.3) (Q8I0X2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MSIILTFLALFVFLICVFPCITEDTHKYVYSEICGKGANENESSVYCMKDHKKKNSLYVYKHIMKFFIDKYKSIPNEIALVEHSYGEPQNYITYDNFFRKVSSFSHTLNTYEGKGIESKKYNEKQNNGIFKLLGIYGSNSINWLASDLSAMMSGVTTLVMHSKFSIDVIVDILNETQLEWLCLDLDLVEGLLNHINELPHLKNLIILDTLSKNKEINLNKEENNNDKKNKSSGNSTSVKGNDLSNMIEITCSGPLEYDKEKLKKYNELKKKCEKCGKKLMLFDDMTKTQTKKFTIKNEDPDFVTSIVYTSGTSGKPKGVMLSNKNIYNQLFSLYNHSVRERYSFKNHLSYLPISHVFERTFAYSILMYGGTLNVWGKDINYFSKDIYNTKENIMGGVPKVFCRIYTNIMTEIDNLPSPKRRLVRKILSLRKSDHNGPFSKFLESIFHISKKIKDKVNPNLEIILSGGGKLSPDIAEEFCYLLNIKYCQGYGLTETAGAILGNHADDEHFEYIGGPIAPNTKYKVRTWETYKATDTLPKGELLIKSDSMFSGYFLEKECTKNAFTDDGYFKTGDIVQINDNGSVTFLDRSKGLVKLSQGEYIETDLLNNLYSQISFINNCVVYGDDSMDGPLAIISVDKYLLFLSLKDDNMLEMTGVNEQNYLDKLTDDNINNNIFLDYVKEKMLEVYKETNLNRYNIINNIYLTSKVWDTNNYLTPTFKVKRFYVFKDYAFFISQVKEIYNNKLKGCAPISVNSENKDEEKKNDSKKKEEKDSEKLSNESTSNQNKNDMGKHEKYVENKKVKLGATYGTRQKEMNK
Protein: Protein BEX3 (Brain-expressed X-linked protein 3) (Nerve growth factor receptor-associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) (p75NTR-associated cell death executor) (Q00994)
Organism: Homo sapiens (Human)
Function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9WTZ9}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 16
- 14-3-3 protein epsilon
- Transcription elongation factor A protein-like 7
- Transcription elongation factor A protein-like 9
- Transcription elongation factor A protein-like 1
- Beta-nerve growth factor
- Caspase-2
- Melanoma-associated antigen D1
Sequence:
MANIHQENEEMEQPMQNGEEDRPLGGGEGHQPAGNRRGQARRLAPNFRWAIPNRQINDGMGGDGDDMEIFMEEMREIRRKLRELQLRNCLRILMGELSNHHDHHDEFCLMP
Protein: Mitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Mitochondrial phospholipase) (MitoPLD) (Protein zucchini) (Q9VKD7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:20966047, ECO:0000269|PubMed:21397848}; Single-pass membrane protein {ECO:0000269|PubMed:20966047, ECO:0000269|PubMed:21397848}. Note=as initially reported to localize to the perinuclear meiotic nuage (also known as germline granule or P granule), a germline-specific membraneless ribonucleoprotein biocondensate involved in post-transcriptional regulation of transposons and mRNAs (PubMed:17543859). However, it was later shown that the EGFP tag at N-terminus used in initial experiments interfered with mitochondrial localization and caused it to form perinuclear aggregates (PubMed:20966047, PubMed:21397848). These aggregates do not colocalize with components of the perinuclear nuage (PubMed:26295961). {ECO:0000269|PubMed:26295961}.
Interaction partners:
- Probable RNA helicase armi
- GH09064p
- Protein piwi
- Protein aubergine
- Protein vreteno
- Probable ATP-dependent RNA helicase spindle-E
- Tudor domain-containing protein krimp
- Protein argonaute-3
- Small RNA 2'-O-methyltransferase
- Inactive peptidyl-prolyl cis-trans isomerase shutdown
Sequence:
MLITQIIMKQIRDYPIVSTISIAVSTVLASEVIWKLVQCSRSKREKASRVHEVIIFNELGEICAAVHMRNSSMGSQKPQVSPCCNTHCSLRNVAKIVEQIDRAVYSIDLAIYTFTSLFLADSIKRALQRGVIIRIISDGEMVYSKGSQISMLAQLGVPVRVPITTNLMHNKFCIIDGFERVEEIRLLRKLKFMRPCYSIVISGSVNWTALGLGGNWENCIITADDKLTATFQAEFQRMWRAFAKTEGSQIQLK
Protein: NAC domain-containing protein 37 (ANAC037) (Protein VASCULAR RELATED NAC-DOMAIN 1) (Q9SL41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9C8W9, ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- Transcription factor MYB46
- Transcription factor MYB83
- Cysteine protease XCP1
- Transcription factor MYB58
- LOB domain-containing protein 15
- LOB domain-containing protein 30
- Homeobox protein knotted-1-like 7
- MYB transcription factor
- At5g52380
- Transcription factor MYB52
Sequence:
MEPMESCSVPPGFRFHPTDEELVGYYLRKKIASQKIDLDVIRDIDLYRIEPWDLQEQCRIGYEEQNEWYFFSHKDKKYPTGTRTNRATMAGFWKATGRDKAVYDKTKLIGMRKTLVFYKGRAPNGKKSDWIMHEYRLESDENAPPQEEGWVVCRAFKKRATGQAKNTETWSSSYFYDEVAPNGVNSVMDPIDYISKQQHNIFGKGLMCKQELEGMVDGINYIQSNQFIQLPQLQSPSLPLMKRPSSSMSITSMDNNYNYKLPLADEESFESFIRGEDRRKKKKQVMMTGNWRELDKFVASQLMSQEDNGTSSFAGHHIVNEDKNNNDVEMDSSMFLSEREEENRFVSEFLSTNSDYDIGICVFDN