wanglab/gogpt-training-data huggingface dataset:
Protein: Developmental regulator flbA (P38093)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Required for asexual sporulation and normal colony development. May be involved in brlA activation. Could play a regulatory role in controlling the flug-initiated signal transduction pathway that triggers the asexual reproduction.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- G-protein beta subunit
- Guanine nucleotide-binding protein alpha-3 subunit
- C2H2 type master regulator of conidiophore development brlA
- Protein fluG
- Guanine nucleotide-binding protein alpha-2 subunit
- Protein kinase domain-containing protein
- C2H2-type domain-containing protein
- Regulator of G protein signaling domain protein
- MYB family conidiophore development protein FlbD
Sequence:
MPTSISTAPLSQGSPPSSLIDYQPQSVPSSSSPPPSTAAAAAAAVVVAVPSSSSPVDLGLPSFTSTSSLITSDVPATTTTPSFTGSVIGSISRRNRRSFAALAREKTSSALANLSSIGSTTNSSLRQSASSGSLQKHSRKASQLSVGEISGFVPLSPPLSDGSGSSEQSSSAPFEPLSAVTEQPNPAAERRRQTIQLVPPISENIPVSPAKMHQTSSRLLRMTEDDRPFTKDFMDLFSTLMVSLKLDSHRVRFTKYDHTFTSEEAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKEMARSVCQRFVDARFIESVDGKYSHTFPLKGALYQLTPKGINILQRFCQRNGITARHVIDVLESPRNTMQLVNLERDTETDKLSHDRATIEVIFRRFAGQDGPNVKSSVSSSDSDSLSDYSNGLVGVKMARERKVGDKICANTFTGKAAVDWLMDCSTTIEPRETVLIAELFVKYGLITVLQEDRSMPQVENSLVAFQPSKNAIYAITERGQRVCGWLARDKPRDTTTYDSRGIPRDSNNARLNHILQDPALRLLFREFLRFSLCEENLSFYIDVSEFTTQYHKFDKVGHFKKPDAVRETLAAAYGLYNAFLAPGSPCELNIDHALRNSLASRMTKAVGDDDSMLKSLQEVVQLFEMAQTSVFKLMSSDSVPKFLRDPKYSAILQEHDVDDLIGGGRSYSPTPGNVPERSMSRSQRS
Protein: Furrowed, isoform A (Furrowed, isoform C) (RE10878p) (Q9VYR4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD35927p
- GPI inositol-deacylase
- Hector, isoform A
Sequence:
MFCCNIPVDASVATSTSTSISTYPLQRATKRAMTPPNAMALIMLLLLALCAAGNGQICGPPAVPLNAKVRTITVDSQIAEAHYECDAGYELFGPSAVKCDRRTGWDRDLPFCGVNVAYRKPVNQSSYTRSGPASYANDGKPGNKNPDGQECSETQKEPSPWWRVDLLTPQAVHVVRITTRGCCGHQPLQDLEIRVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLVGQYVAIQLVGVEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCYDFHITKGESFDKAQAICKQTGGDLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVMGKKFTLGEKIQYTCPKGHSLLGQTERECRLDGTWSGSSPTCKYVDCGSLPELKFGSIHMSEERTSFGVVATYSCHENYTLIGNENRTCAMDGWSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVCELVTCETPSVPSGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVATFKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHCIPNYNRIGQYLRKCTEDGAWSGKQPRCELATAEGQETSELGTGVGIGATVIVALLVIFGLIFLYRNKARPVKNTENVQAAETKDERNAAVMSYSTLEANNRMHMDNNPSATFNTFHGGAGGRSNGGGNPDANSNGERLNNNRSENIYDQIPNEQFYDAPYEMRTNDEVYEPEPVASNVITINGISVR
Protein: Homeobox protein Nkx-2.2a (Homeobox protein NK-2 homolog B-A) (Q90481)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P42586, ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Oligodendrocyte lineage transcription factor 2.
- Paired box protein Pax-6
- Forkhead box protein A2
- Sonic hedgehog protein
- Insulin gene enhancer protein isl-1
- Paired box 4.
- Neurog3 protein
- Oligodendrocyte transcription factor 1
- Transcription factor SOX-10
- Neurogenic differentiation factor 1
Sequence:
MSLTNTKTGFSVKDILDLPDTNDEEGSITGTEEDTEGSEATKTPGVLVQSPLENVQNLPLKNPFYDNSDNPYTRWLATTDSIQYSLHGLSANSQDTSAKSPEPSADESPDNDKETSSNGSDSGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVAVPVLVRDGKPCHTLKAQDLAATFQAGIPFSAYSAQSLQHMQYNAHYSAATTPQFPTAHHLVQTQQWTW
Protein: Transforming growth factor alpha (Q6J1M9)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
Sequence:
MPGEAAALALGVLVAVCHALENTTSALSDPPVAAAVRSHFNECPDSHRQFCFHGTCRFLVQEDKPACVCHSGYVGTRCEHADLLAVVAANQKKQTITALLVVAVVASAVLIAACVLVHCCRMRKRCGCCRVPLCGQEKPSGLLKGGASCCHTESVV
Protein: Insulin gene enhancer protein ISL-1 (Islet-1) (P61374)
Organism: Rattus norvegicus (Rat)
Function: DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P61372}.
Interaction partners:
- LIM/homeobox protein Lhx3
- LIM domain binding 1
- Homeobox protein Nkx-2.5
- LIM domain binding 2
- POU domain, class 4, transcription factor 2
- Paired box protein Pax-6
- Homeobox protein Nkx-6.1
- Transcription factor GATA-4
- POU domain, class 4, transcription factor 1
- T-box transcription factor TBX5
Sequence:
MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
Protein: Mitochondrial inner membrane protein Mpv17 (Protein Mpv17) (Q5TZ51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23862018}; Multi-pass membrane protein {ECO:0000269|PubMed:23862018}.
Interaction partners:
- Melanocyte inducing transcription factor a isoform 1
- deoxyguanosine kinase
- DNA polymerase subunit gamma-1
- Src homology 2 domain containing transforming protein D
- Solute carrier family 45 member 2.
Sequence:
MAGLWRSYQALMAKHPWKVQIITAGSLVGVGDVISQQLIERRGLANHNARRTAKMMSIGFFFVGPVVGGWYKVLDKLVTGGTKSAALKKMLVDQVGFAPCFLGAFLGITGTLNGLTVEENVAKLQRDYTDALISNYYLWPPVQIANFYFIPLHHRLAVVQIVAVVWNSYLSWKANKM
Protein: LP03809p (Q8SZX4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEIRSVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESATTQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLVTGVLDRNDLQRMQQTPASGYPGALDDLIFSGAGSGCRGDDEDECTPPFESGSGDDLITPVYVPPTKQTTTSQQGNSLSTGGSSSGGVITNGTERACDDEDCVHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMGGSGRNDHDRMQLPDEHHPLPPLPPPIPPQDPPPYGPYGGNTYNTNMNNYRPKGKGGRINSIEEERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRGYKTESEKAAAYGSHNPNAALLGNTSTNGSYHQQRQHHMHGGGGGGGAGQQQHHAQQQMHNGHNGNGNGGGGGGGGMMSSGSGSLGYGSDGRPQMAGLVQPKAKKRDSKDVKEWYV
Protein: Aldehyde dehydrogenase 1 family member B1 (A0A0U1RQK9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKP
Protein: Tail fiber receptor-binding protein (Major tropism determinant protein) (Q775D6)
Organism: Bordetella phage BPP-1
Function: Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.
Subcellular location: Virion. Note=Part of the tail fibers. {ECO:0000269|PubMed:20160083}.
Interaction partners:
Sequence:
MSTAVQFRGGTTAQHATFTGAAREITVDTDKNTVVVHDGATAGGFPLARHDLVKTAFIKADKSAVAFTRTGNATASIKAGTIVEVNGKLVQFTADTAITMPALTAGTDYAIYVCDDGTVRADSNFSAPTGYTSTTARKVGGFHYAPGSNAAAQAGGNTTAQINEYSLWDIKFRPAALDPRGMTLVAGAFWADIYLLGVNHLTDGTSKYNVTIADGSASPKKSTKFGGDGSAAYSDGAWYNFAEVMTHHGKRLPNYNEFQALAFGTTEATSSGGTDVPTTGVNGTGATSAWNIFTSKWGVVQASGCLWTWGNEFGGVNGASEYTANTGGRGSVYAQPAAALFGGAWNGTSLSGSRAALWYSGPSFSFAFFGARGVCDHLILE
Protein: Terpenoid synthase 9 (AtTPS09) (EC 4.2.3.-) (Q8L7G4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in terpene biosynthesis in roots. Possesses diterpene (C20) synthase activity in vitro. Does not seem to be involved in sesquiterpene (C15) biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Putative inactive
- Geranylgeranyl pyrophosphate synthase 3, chloroplastic
- Probable alpha,alpha-trehalose-phosphate synthase 7
Sequence:
MEATSVFRPKLGSQFSLPSTTNLFPLRKLYGFPLTSFPGKPIKRIRLKATNTLTFDDKERTRKFKKLPLSEWTHYFHSIPLDISEMDALKEEIDELKPKVKNTFMSSQGSDSTKTKILMIYLFVSLGLAYHFEEEIYETLKEGFENIEKIMAGEEDLYTVSIIFWVFRRYGHYISSDVFQRFKGSNGSFKESLIGDAKGMLSLYEAAHLATTKDYILDEALIFTSSHLETLVATGTCPPHLLARIRNALSICQHWNFEVLVPLDFIPFYEQEKDHDEMLLKFAKLSFKYLKLIYLQDLKILTKWYKKLDFPSKFPPYFKDRCVENYFFVLPVFFEPQLSSARMLLTKGFILLGIQDDTFDRYASISEAESLGNSLKRWAPDHSMDKQPEYLKSVLKVILDTFQEFEKELSPEGRSYSVKYTIEEFQASSKANVELAKWAQVSHVPSFEKYMEVGQMEITACVTVAYILMSMGKTGTKEAFEWLKSRPKLVQSLCTKGRLMNDIAGFEDDMSRGYVVNAVNCYMKQYGVTEKEAFKELRKMVVNTHKTLNEEFLTTTCVSHYVLRETMDFARMIIVTYNGYEGFTRPDEGKIEEYMTSLFVDHTLKML
Protein: T. brucei spp.-specific protein (Q38FE2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVVKRRGNGRLGKPPTDTGVSENSTGGTPPPESASQRGGAKQTTVASAIKQPASMPDGSLSQDRRKRRRRLSVPEEVAHAVVEGEEATGAVRDERLPENTRVVEPQLNDHDGKERYPLGVVQFPEEQRPWRSARRKAGVAEGGSDEVNAAQLPPTGNAVPQKPTRRLGRASAPPIPPVGTVEHDLQTTGGTCTSAPIAGDRASRTFQAAASPSEDIKQRPHRIPLIIDKGRFSKQKVEAPPGTATVVPMDTGENQAGVCEANSAPPTSCSHRGAQRLGHGQPADGTSGAVDSIEEGPGRGIEEASVDARRRRFMQVPVSRISLYTRLAEGGLDAADRPFVTCVVKHAQSSVSAWVSGFLSP
Protein: FI07245p (GH16917p) (RH74704p) (Vesicular monoamine transporter, isoform C) (Vesicular monoamine transporter, isoform E) (Vesicular monoamine transporter, isoform F) (Q86NW1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQSSTDAGNGGPRKHTQSTAPQKQSEISETTSFTVNANTTTNSQQQQIPGGPASNTPSKNPFKQQLDSNQQNGNMEPDCGIMGVGKEPPVPPPPTYQSQTYAGRQAPPPADQYREEDPRAAGSWAAAKSWMVSWRGSNRLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLDSFPRTPLTSNVPPPPTPCPCNKDGSEAAPLEISTISPEENETYYRELEERHNELVGETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGLALGVLIGPPFGGVMYEFVGKSAPFLILAALALGDGLLQLFMLQPSIQKAETEPPSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFEWMLFGIAILCFMYAPLLTLLKNPPTSDEKKSLIYGRDRAQVRYVTYQNYEEDE
Protein: Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS2) (EC 6.-.-.-) (Q14CH7)
Organism: Mus musculus (Mouse)
Function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular location: Mitochondrion.
Interaction partners:
- Tyrosine--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Aspartate--tRNA ligase, mitochondrial
- Alanine--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, mitochondrial
- Valine--tRNA ligase, mitochondrial
- Valine--tRNA ligase
- Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
- Probable leucine--tRNA ligase, mitochondrial
- Threonine--tRNA ligase, mitochondrial
Sequence:
MAVALAAAAGKLRRAIGRSCPWQPFSTEPGPPHGAAVRDAFLSFFRDRHGHRLVPSATVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVVNSQKCVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACSMAWELLTQVYGIPEDRLWVSYFSGDSQTGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGSPQLVELWNLVFMQHYREADGSLQLLPQRHVDTGMGLERLVAVLQGKRSTYDTDLFSPLLDAIHQSCGAPPYSGRVGAADEGRIDTAYRVVADHIRTLSVCIADGVSPGMSGAPLVLRRILRRAVRYSTEVLQAPPGFLGSLVPVVVETLGSAYPELEKNSVKIASLVSEDEAAFLASLQRGRRIIDRTVKRLGPSDLFPAEVAWSLSLSGNLGIPLDLVELMLEEKGVKLDTAGLEQLAQKEAQHRAQQAEADQEDRLCLDVHALEELHRQGIPTTDDSPKYNYTLHPNGDYEFGLCEARVLQLYSETGTAVASVGAGQRCGLLLDRTNFYAEQGGQASDRGYLVRTGQQDMLFPVAGAQLCGGFILHEAMAPERLQVGDQVQLYVDKAWRMGCMVKHTATHLLSWALRQTLGPTTEQRGSHLNPERLRFDVATQTLLTTEQLRTVESYVQEVVGQDKPVFMEEVPLAHTARIPGLRSLDEVYPDPVRVVSVGVPVAHALGPASQAAMHTSVELCCGTHLLSTGAVGDLVIIGERQLVKGITRLLAITGEQAQQAREVGQSLSQEVEAASERLSQGSRDLPEAHRLSKDIGRLTEVAESAVIPQWQRQELQTTLKMLQRRANTAIRKLEKGQATEKSQELLKRHSEGPLIVDTVSAESLSVLVKVVRQLCKQAPSISVLLLSPQPTGSVLCACQVAQDATPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGHTADLEAALGTARAYALSQL
Protein: Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) (O55222)
Organism: Mus musculus (Mouse)
Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Subcellular location: Cell junction, focal adhesion {ECO:0000269|PubMed:18325335, ECO:0000269|PubMed:18483218}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q13418}. Cell projection, lamellipodium {ECO:0000269|PubMed:18325335}. Cytoplasm {ECO:0000250|UniProtKB:Q13418}. Nucleus {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q13418}.
Interaction partners:
- Beta-parvin
- Gamma-parvin
- Alpha-parvin
- Integrin beta-1
- LIM and senescent cell antigen-like-containing domain protein 1
- Paxillin
- RAC-alpha serine/threonine-protein kinase
- Fermitin family homolog 2
- Talin-1
- Vinculin
Sequence:
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Protein: Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) (Q9UKU0)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}.
Interaction partners:
- Fatty acid synthase
- Carnitine O-palmitoyltransferase 1, liver isoform
- Lipoprotein lipase
- Lysosomal thioesterase PPT2
- Palmitoyl-protein thioesterase 1
- Monoglyceride lipase
- Diacylglycerol O-acyltransferase 1
- Beta-alanine-activating enzyme
- Palmitoyl thioesterase CPT1C
- Long-chain-fatty-acid--CoA ligase ACSBG1
Sequence:
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
Protein: Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) (Q03385)
Organism: Mus musculus (Mouse)
Function: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16580637}. Nucleus {ECO:0000269|PubMed:16580637}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000269|PubMed:16580637}.
Interaction partners:
- GTPase HRas
- GTPase KRas
- Ras-related protein Ral-A
- GTP-binding protein REM 1
- Ras-related protein R-Ras
- Ras-related protein Rap-1A
- Ras-related protein Ral-B
- GTPase NRas
- Ras-related protein M-Ras
- Ras-related protein Rap-1b
Sequence:
MMVDCQSSTQEIGEELINGVIYSISLRKVQLHQGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEAESEALSPAPVLSLKPASQLEPALLLTPSQVVTSTPVREPAAAPVPVLASSPVVAPAPELEPVPEPPQEPEPSLALAPELEPAVSQSLELESAPVPTPALEPSWSLPEATENGLTEKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKAPDRARVVEHWIEVARECRALKNFSSLYAILSALQSNAIHRLKKTWEEVSRDSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRAQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPEEHFGTWFRAMERLSEAESYTLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLGSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELVQIISEDHKLKIPENANVFYAMNSTANYDFILKKRTFTKGAKVKHGASSTLPRMKQKGLRIAKGIF
Protein: Chromodomain-helicase-DNA-binding protein 3 homolog (CHD-3) (EC 3.6.4.12) (Q22516)
Organism: Caenorhabditis elegans
Function: Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DIOX_N domain-containing protein
- Probable histone-binding protein lin-53
- Transcription factor dcp-66
- Probable histone-binding protein rba-1
- Protein let-418
- Histone deacetylase
- Histone deacetylase 1
- Methyl-CpG binding protein 2/3 C-terminal domain-containing protein
- Nuclear receptor corepressor 1
- Putative histone deacetylase 2
Sequence:
MSDDQHESIDGDETMEEDSMLAEGHEDGEEDVGEDEEEVETEESQGVPTTSEKKKPPPKKKKGGKKSSKKKNNCDYPDPYKSTSAEISAAIGLTDVDVDYEQEEFQSITNLKNFSSLVKPYILKVNPGTNVTKMYPLFQVKYKEFQDHMTAHGKSIQKQQRAKFVPVPVPVTPQEKIIPQKTRSSARRKRRDGSDGEGGGHDSDQEFEALIKQHEKQQDEAEKGKEEARINRAAAKVDKRKAALESARASKRARKEQGVVEENHQENCEVCNQDGELMLCDTCTRAYHVACIDENMEQPPEGDWSCPHCEEHGPDVLIVEEEPAKANMDYCRICKETSNILLCDTCPSSYHAYCIDPPLTEIPEGEWSCPRCIIPEPAQRIEKILSWRWKEISYPEPLECKEGEEASKDDVFLKPPRKMEPRREREFFVKWKYLAYWQCEWLSETLMDVYFTALVRMYWRKVDSENPPIFEESTLSRHHSDHDPYKLRERFYQYGVKPEWMQIHRIINHLSYAKSQQDYLVKWKELSYEHATWERDDTDIANYEDAIIKYWHHRERMLNDEVPRNVQKMIAKQREAKGLGPKEDEVTSRRKKREKIDILKKYEVQPDFISETGGNLHPYQLEGINWLRHCWSNGTDAILADEMGLGKTVQSLTFLYTLMKEGHTKGPFLIAAPLSTIINWEREAELWCPDFYVVTYVGDRESRMVIREHEFSFVDGAVRGGPKVSKIKTLENLKFHVLLTSYECINMDKAILSSIDWAALVVDEAHRLKNNQSTFFKNLREYNIQYRVLLTGTPLQNNLEELFHLLNFLAPDRFNQLESFTAEFSEISKEDQIEKLHNLLGPHMLRRLKADVLTGMPSKQELIVRVELSAMQKKYYKNILTRNFDALNVKNGGTQMSLINIIMELKKCCNHPYLFMKACLEAPKLKNGMYEGSALIKNAGKFVLLQKMLRKLKDGGHRVLIFSQMTMMLDILEDFCDVEGYKYERIDGSITGQQRQDAIDRYNAPGAKQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKGSVEERITSVAKKKMLLTHLVVRAGLGAKDGKSMSKTELDDVLRWGTEELFKEEEAPVEGADGEGTSSKKPNEQEIVWDDAAVDFLLDRNKEEEGQDGEKKEHWTNEYLSSFKVATYNTKEADDADDDEDETEVIKEGTEEQDPNYWEKLLKHHYEQDQETELQKLGKGKRVRRQVNYASENMGQDWSAQNNQQQEEDDGSEYGSDNGELLQTDEDYEERRRRREERSEKLPPLLAKVNGQIEVLGFNPRQRKAFYNAVMRWGMPPQDLTQSSWQVRDLRNKSEKVFKAYSSLFMRHLCEPVVDNSDSFMDGVPREGLNRQAVLSRIGLMSILRKKVQEFEKFNGEWSMPETREKMLATAAQASVSNLPGMIKIKEEPIDIDETPMDVDQSNITKTEELASEVKVEEEPKAPRLPYKFNICDGGYTELHSLWINEEKVARNGKEYEIWHRRHDFWLLAAVAVYGYGRYQINFQDIMNDPKFSIVNEPFKQTGADPATNFADVKNKFLARRFKLLEQSLVIEEQLRRAAHINKQQSPDQVGQLAQHFSELEHTADAHVNIARESNNGNRNANAILHKCLAQLDDLLSDLKTDVARLPATISQVRPVTERLQMSERQILSRLVVAKDPDAAPSKPALPPSGPFITPLFNQNFTTIQPKFPSLFDCNLSPDDEPIDIEGSISAAVAEASRASSIAATKDEPMDTSDKDIPSTSAAAGSSYPRY
Protein: Fatty acid-binding protein 9 (15 kDa perforatorial protein) (PERF 15) (Testis lipid-binding protein) (TLBP) (Testis-type fatty acid-binding protein) (T-FABP) (P55054)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MIEPFLGTWKLVSSENFENYVRELGVECEPRKVACLIKPSVSISFNGERMDIQAGSACRNTEISFKLGEEFEETTADNRKVKSLITFEGGSMIQIQRWLGKQTTIKRRIVDGRMVVECTMNNVVSTRTYERV