wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Q9EPU2)
Organism: Rattus norvegicus (Rat)
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Estrogen receptor
- Histone lysine acetyltransferase CREBBP
- Nuclear receptor coactivator 2
- Histone-arginine methyltransferase CARM1
- Estrogen receptor beta
- Nuclear receptor coactivator
- Mediator of RNA polymerase II transcription subunit 1
- Progesterone receptor
- Transcription factor Jun
- histone acetyltransferase
Sequence:
IIRRCIQRFFSLNDGQSWSQKRHYQEAYIHGHAETPVYRFSLADGTIVSAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGCRPNPILQDKGIRPPAAGCGMSLSPSQSVQMLGSRTYGVADPSNTGQMAGARYGASSSVASLTPGQSLQSPSSYQSNSYGLNMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGVHSPMGSSGNTGSHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNINQPSKASSQDSKSPLGLYCEQNPVESSVCPSNSRDPPVTKENKENSGEASETPRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSNCKDSSISVTSPSGVSSSTSGAVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSTASGGEGSVXQEQLSPXKKENNALLRYLLDRDDPSDVLAKELQPQADGGDSKLSQCSCXTNPSSGQEKDPKIKTEEVSGDLDNLDAILGDLTSSDFYNSPTNGSHPGAKQQMFAGPSSLGLRSPQPVQSVRPPYNRALSLDSPVSVGSVPPVKNVSAFPVLPKQPILAGNPRMMDSQENYGANMGGPNRNVPVNPTSSSGDWGLANSRASRMEPLASSPLGRAGGDYSAALPRPALGSSGPTLPLRSNRLPGARPTLMLQMRAGEVPMGMGVSPYSPAVPSNQPGSWPEGMLSMEQGPHGAQNRPLLRNSLDELLGPPSNPEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVSQGQALESKQDVFQGQEAAVMMDQKAALYGQTYPAQGPPLQGGFHLQGQSPSLNSMMSQISQQGSFPLQGLHPRASMVRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALEMKMESPTGAAVMRPMLQSQQAFFNAQMAAQQKRELMNHHLQQQRMAMMMSQPQPQAFSPPPNVTASPSMDGVLAGSAMPQAPPQQFPYATNYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMVQHPQTAPMYQSSEMKGWPSGNLARNGSFPQQQFAPQANPAAYNMVHMNSSGSHLGQMTMTPMPMSGMPMGPDQKYC
Protein: Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) (P04075)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Subcellular location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Fructose-bisphosphate aldolase C
- ATP-dependent 6-phosphofructokinase, liver type
- ATP-dependent 6-phosphofructokinase, muscle type
- ATP-dependent 6-phosphofructokinase, platelet type
- Alpha-enolase
- Glucose-6-phosphate isomerase
- Pyruvate kinase PKM
- Phosphoglycerate mutase 1
Sequence:
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY
Protein: Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) (Q9H2E6)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:32302524}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Plexin-A4
- Plexin-A2
- Plexin-A3
- Neuropilin-2
- Neuropilin-1
- Plexin-A1
- Ena/VASP-like protein
- Plexin-D1
- Plexin-C1
- Hepatocyte growth factor
Sequence:
MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESRGGMLDWKHLLDSPDSTDPLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPGNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQTGLSKRLEMHHSSSYGVDYKRSYPTNSLTRSHQATTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT
Protein: Transcriptional co-repressor SIN3A (O17143)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00810}.
Interaction partners:
Sequence:
MMKRTRVDEVQFGTRPVPQTSGGVGVGVVGVTGGGPTSGGGGTATVGVNTTGVTIGTVVPSAHNATISGIGSIHHRILTPQHGGAQTIAYLPSTTPTATNLKTTTSIVDSTTAGGPVGAGAQVAVGIGSAAGGRSVVVSTGSTGTQTLQYTTSYSVASIQAGGTLKANTADGANTVQIHVTGRRTANNPASAQTVSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQMAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGCTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELIPRLEIT
Protein: Protein DBF4 homolog A (Q7ZZH7)
Organism: Xenopus laevis (African clawed frog)
Function: Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit.
Subcellular location: Nucleus {ECO:0000269|PubMed:14561731, ECO:0000269|PubMed:15222894}.
Interaction partners:
Sequence:
MKSTVAAVKNPTGKVQADVCKPFTGKLFYLDLTSKLISEKLEKDIKELGGAIEGFLSKEISYLITSKKEAKCVKTLKYVCSIPSPEAAPNTGESSTSPGNRRLCQEGNSSKKNEKSLVSRGKSLVKRAIKEQEILPKNSILSNALNWGVKILHVEEAKHYIEKKKTALQQVRKSQPVVKVESKPQTRRKVKPQKLKSPYIKVEDCSCQYRPLYLVLPQFRSFQNPVSNYSVEVDKKADPGQKLPETKQSVNKTGHGQDGANNPNIKLKEQKKHGYCECCLKKYDDLESHILSPQHKNFSESAYYQVVDDLISTFDFDFVDWSKYKNGRKGVGILMLAEKSKTEGQERNEANLFVSKTHNFSERVTATTPLQENTLKDQHASPCSLPCTPACNADQMFSLPSPAGSARLCNKKYKMDSNFGQLVATPLPSFNLKDSLTGSFGGREMFVAKLNETMEPATEGPKIKWDVCNIPSNISQCIPQKVDPIAQHVNQFPNGNTHCSEMTACQAALIYENVDSAADANIKLPKTVNDLHNKEGHRATDKIYPTVQSHEYLPDYSPSGNLHRKVKTSAHRNKNKDELFCRLSHKVSVPQQEDDSKFPSETLLALFESSEDKTEFFGFAGSPAYESCSMDDGDTPDQTHKKMLLSLFPHTTTSGSSFLGF
Protein: Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper-containing 2 (DCC-interacting protein 13-beta isoform X1) (F1RB27)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Cytoplasmic vesicle, phagosome {ECO:0000256|ARBA:ARBA00004262}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004220}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- HESX homeobox 1.
- PH domain-containing protein.
- Non-specific serine/threonine protein kinase.
- non-specific serine/threonine protein kinase
- V-akt murine thymoma viral oncogene homolog 2,-like.
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- small monomeric GTPase
- Adiponectin, C1Q and collagen domain-containing, b.
- Si:ch211-127d4.3.
Sequence:
MPAVHHKLLLEEALQDSPQTRSLLSVFEEDAGTLTNYTNQLLQSMQRVFGAQNEMALATEQLSKQLLEYEKQNFALAKGDEEVINTLQQFAKSVEELNALHSELSTQIADKMVFPMVQFREKDLTEISTLKEIFSIATDEHEAAMVKYSRLPKKRENEKVKAEVVREVAYSRRKQHQAAMQYYCALNALQYRKRVAMLEPMLGYTHAQINFFKKGMELVSKKLDSFLNSVSNMNESIESQLEIDAEVMRSSQRELLSVDDSVYMPDHDQAAVSRALIQKAGYLNIRNKTGLVTTAWDRLFFFTQGGNLMCQPRGAVAGGMVLDLDNSSVMAVDCEDRRYCFQITSPNGKTSLILQAESKREYEEWICTLNNISRQIYLTDNPEAVAIKLHQTALQAVTPITSFEKRAEGSPNPDRAKPGGLPVTSQEAEKSSVSLEPEDLIVPGTPIQFDIMLPASEFLDQNRAGARRTNPFGETEEDDDESDTHDSLLQQVFAVRFLGSMAVRSGHTQEVIYEAMRQVLAARAIHNIFKTTESHLMISSSCIRLIDPQTQVTKISFQLQDVSEFAAHQENERLMGFVVRSSAEDDEPSFSVFVFESNTEGEKICYTINLAKEIADARKDPEALAQLMKSMPLTNDGKFLLLDNETGDTAETAGQEEQESEA
Protein: Thiamine biosynthetic bifunctional enzyme BTH1, chloroplastic [Includes: Thiamine-phosphate synthase (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase) (TMP-PPase); Hydroxymethylpyrimidine kinase (HMP kinase) (EC 2.7.1.49)] (O48881)
Organism: Brassica napus (Rape)
Function: Essential for thiamine biosynthesis. Bifunctional enzyme that catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP and condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
Sequence:
MQSLGGIRSWPATWRTTTASMTTTTTESVRKVAQVLTVAGSDSGAGAGIQADIKVCAARGVYCASVKTAVKAKNTRAVQSVHLLPPDSVSEQLKSVLSDFEVDVVKTGMLPSPEIVEVLLQNLSEYPVRALVVDPVMVSTSGHVLAGSSILSIFRERLLPLADIITPNVKEASALLGGVRIQTVAEMRSAAKSLHQMGPRFVLVKGGDLPDSSDSVDVYFDGNEFHELHSPRIATRNTHGTGCTLASCIAAELAKGSNMLSAVKVAKRFVDSALNYSKDIVIGSGMQGPFDHFLSLKDPQSYRQSTFKPDDLFLYAVTDSRMNKKWNRSIVDAVKAAIEGGATIIQLREKEAETREFLEEAKSCVDICRSNGVCLLINDRFDIAIALDADGVHVGQSDMPVDLVRSLLGPDKIIGVSCKTQEQAHQAWKDGADYIGSGGVFPTNTKANNRTIGLDGLREVCKASKLPVVAIGGIGISNAESVMRIGEPNLKGVAVVSALFDQECVLTQAKKLHKTLTESKREH
Protein: Large ribosomal subunit protein uL15 (50S ribosomal protein L15) (P9WHD7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Binds to the 23S rRNA.
Interaction partners:
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein bL35
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein bS20
- Large ribosomal subunit protein bL36
- Large ribosomal subunit protein uL5
Sequence:
MTLKLHDLRPARGSKIARTRVGRGDGSKGKTAGRGTKGTRARKQVPVTFEGGQMPIHMRLPKLKGFRNRFRTEYEIVNVGDINRLFPQGGAVGVDDLVAKGAVRKNALVKVLGDGKLTAKVDVSAHKFSGSARAKITAAGGSATEL
Protein: GH23813p (Moca-cyp, isoform B) (Moca-cyp, isoform C (EC 5.2.1.8)) (Q9VAW2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRAERSKSLDREERGARGQDRDRGKDQDRDRSRNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQKRTIKLSDLERIEEESKMREEEMKRREHERKRRHEEATKNPKQSFFELSHASTYGGKITPDRFSPEHKAKSKDTADRGKAKEREKAGEKDKARDVTPVKRRKSMDMNALDYEQQTESEVESEDEEQLKVKPPSKQDIRVEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPARRQQRSPARRPGQNYNQNQNQNQNQNQNQNQLNRGNRRNPFADRDRRRRSRSQDNEYRNRYPLSPIRGRGSPSGDRRRQQRSRSQNRRQDSPSQRRQLSPGRKRQDSPSKKRPNSTERKWRDSPERKRDDSHDRKREASPNWKRDDSPARKRKDSANRKREDSQDKKIQDSKRQEDSAGKKREDSPSKKRKDSDKKRQDSPVKRQESPGRKRQDSPERKRRDSPDRRRKDSPARRRQESSGRRRQDSDGRRRRESSGNRRSRSRGRWHSSSRSRSPSTSRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQKRAEAAMLMKEHMRNEIAKEEERRMEKQRQDDLDKERTTRELNELERLKAETLRKLHEEDSVDPDAAASAGSASKTDATSTGAKSKRDSSSENRHREKKRKHKKSKKSSGRSDND
Protein: Smt3 activating enzyme 1 (Q9VG70)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVDMDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVINHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDPETCAGYVEAIGAK
Protein: Soluble guanylate cyclase gcy-34 (EC 4.6.1.2) (P92006)
Organism: Caenorhabditis elegans
Function: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Bis
- Inosine triphosphate pyrophosphatase
- GTP cyclohydrolase 1
- Probable 3',5'-cyclic phosphodiesterase pde-5
- Probable 3',5'-cyclic phosphodiesterase pde-2
- Soluble guanylate cyclase gcy-33
- Soluble guanylate cyclase gcy-31
Sequence:
MFGFIHESIRQLVIRKYGEDVWLQVLERSGFENGKENIVNHYYSDTDTYVLVDSVSIVLKVTKDQIWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEENPDGTLMLHYFTGRPGLYHIVKGVVKEVAKLVFNLDISLVVQGRTQRSVHMNNGERVEEHVIFLIKNVEEPRRDSDTSTTSALTSVEPDFGEIIDDNLKVSLQDFSRALPYHFVLDESCRLVQCGDELYNHIPNELLQPGTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSPLRKKHMNAMTKEEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQLLSGEHLEPCEYEATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYTSEHAENMCHVALGMMWEARSVMDPVNKTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFLMRSLKKSIWEITDHERDVNVNSIEGYEELEIFIENAQTVKHDGHPKANQNHSATCTIA
Protein: Transcription elongation factor SPT6 (Chromatin elongation factor SPT6) (P23615)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:2201908}. Chromosome {ECO:0000269|PubMed:19683497}. Note=Colocalizes with RNA polymerase II on chromatin (PubMed:2201908). Recruited to the active transcribed loci (PubMed:2201908). Associates with the coding region of HTA1 (PubMed:19683497). {ECO:0000269|PubMed:19683497, ECO:0000269|PubMed:2201908}.
Interaction partners:
- FACT complex subunit SPT16
- Transcription elongation factor SPT4
- Transcription elongation factor SPT5
- Transcription factor SPN1
- DNA-directed RNA polymerase II subunit RPB1
- FACT complex subunit POB3
- RNA polymerase-associated protein CTR9
- DNA-directed RNA polymerase II subunit RPB3
- Histone H3
- RNA polymerase-associated protein RTF1
Sequence:
MEETGDSKLVPRDEEEIVNDNDETKAPSEEEEGEDVFDSSEEDEDIDEDEDEARKVQEGFIVNDDDENEDPGTSISKKRRKHKRREREEDDRLSEDDLDLLMENAGVERTKASSSSGKFKRLKRVGDEGNAAESESDNVAASRQDSTSKLEDFFSEDEEEEESGLRNGRNNEYGRDEEDHENRNRTADKGGILDELDDFIEDDEFSDEDDETRQRRIQEKKLLREQSIKQPTQITGLSSDKIDEMYDIFGDGHDYDWALEIENEELENGNDNNEAEEEEIDEETGAIKSTKKKISLQDIYDLEDLKKNLMTEGDMKIRKTDIPERYQELRAGITDYGNMSSEDQELERNWIAEKISVDKNFDANYDLTEFKEAIGNAIKFITKENLEVPFIYAYRRNYISSREKDGFLLTEDDLWDIVSLDIEFHSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNTASIAELNSLQDIYDYLEFKYANEINEMFINHTGKTGKKHLKNSSYEKFKASPLYQAVSDIGISAEDVGENISSQHQIHPPVDHPSSKPVEVIESILNANSGDLQVFTSNTKLAIDTVQKYYSLELSKNTKIREKVRSDFSKYYLADVVLTAKGKKEIQKGSLYEDIKYAINRTPMHFRRDPDVFLKMVEAESLNLLSVKLHMSSQAQYIEHLFQIALETTNTSDIAIEWNNFRKLAFNQAMDKIFQDISQEVKDNLTKNCQKLVAKTVRHKFMTKLDQAPFIPNVRDPKIPKILSLTCGQGRFGADAIIAVYVNRKGDFIRDYKIVDNPFDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQEVLHKKQIVDSRGHTIPIIYVEDEVAIRYQNSERAAQEFPNKPPLVKYCIALARYMHSPLLEYANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSVEVNKATDNNYYASALKYISGFGKRKAIDFLQSLQRLNEPLLARQQLITHNILHKTIFMNSAGFLYISWNEKRQKYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEEQGTMSEFIELLREDPDRRAKLESLNLESYAEELEKNTGLRKLNNLNTIVLELLDGFEELRNDFHPLQGDEIFQSLTGESEKTFFKGSIIPVRVERFWHNDIICTTNSEVECVVNAQRHAGAQLRRPANEIYEIGKTYPAKVIYIDYANITAEVSLLDHDVKQQYVPISYSKDPSIWDLKQELEDAEEERKLMMAEARAKRTHRVINHPYYFPFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTKKDVVKFIEDYSRVNPNKSVYYFSLNHDNPGWFYLMFKINANSKLYTWNVKLTNTGYFLVNYNYPSVIQLCNGFKTLLKSNSSKNRMNNYR
Protein: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (HMG-CoA reductase 1) (EC 1.1.1.34) (A0A1D8PD39)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). HMG1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase HMG1 finally reduces HMG-CoA to produce mevalonate (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P12683}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Mevalonate kinase
- Squalene epoxidase ERG1
- Lanosterol 14-alpha demethylase
- Isopentenyl-diphosphate delta-isomerase
- Uncharacterized protein
- Farnesyl pyrophosphate synthase
- Acetyl-CoA acetyltransferase
- Squalene synthase ERG9
- Lanosterol synthase
Sequence:
MLSFLTEVTGAIAQTSARRPIQFMVVPALLASIAYLSIIDDYIPEHIKSSSGSSGISYYHPYTSSHYKSQPDLDKWTAIDKEHINDDIYTQANQISVIPLRFRRFQDVVPNVPNAIHISDNEQILIVPTDQIENSLDQLQEITNNGITWKARNNDKLAKYYDYIRYGLNKVQDAIQHAENFDILLIFVAYLGMWYALIKVFVDMRKIGSKFWLAFSTLTSSTFAFLLALLVSNKFLHTKVSLLSLSEGIPFLVSVIGFKHKVSIATIVANSSTASPEDVPHVVGKAVSSHCLSMLRDHLVVIGGLLSCAIYAHHLTGLRNFCILSSLILSFDLILVYTFFSAILGLKVEINRARRTEDLQNALEEEGISSLVAARVAEQSATIEHPNEHNFFKSNNSSIAYFKVIMSLGFFAFHAFWLGSSWLYSTTDGGESFSRFSFLSNIPTLSQDISQQIPIGRKGTVVTILPTIFFMPSGFMVQLEDFIYLVLSKFSSAIRDSIISKFLVFGFALSIVTNVYFLNAARYQVSATHKLIEKEISRPQDSSVTATTTTTATGTTSSGAATSKTIGNNKGLKSVQEIPDNEDESSDEELEIKAPVKVLPLEECVKVLKEGKVKTLSNDEVSSLVVGGKLPLYALEKQLADNKRAVIVRRKAIAKLANAPVLDTNRLPYAHYDYDRVFGACCENVIGYMPLPVGVAGPLIIDEKPYHIPMATTEGCLVASTMRGCKAINAGGGVETVLTRDGMTRGPCVRFPTLKRAGAAKLWIDSEQGQATIKKAFNSTSRFARLQHIQTALAGTSLFIRFRTTTGDAMGMNMISKGVEYSLKYMVEECGWDDMEIVSVSGNYCTDKKPAAINWIEGRGKSIVAAARIPADVVTKVLKSDVDALVELNISKNLVGSAMAGSVGGFNAHAANLVTAVYLACGQDPAQNVESSNCITLMEKDKETGDLNVSVSMPSIEVGTIGGGTILEPQGAMLDLLGVRGPHPTNPGANAQQLAKIVASAVLAAELSLCSALAAGHLVQSHMQHNRSKAPAAGATTTTTPAITDSKASNGSIASNGKDLKRLEEGSVTCIKS
Protein: F-box protein At5g39250 (Q9FL82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box protein At5g49610
- Putative F-box protein At3g23260
- F-box/LRR-repeat protein At2g42720
- F-box/kelch-repeat protein At3g16740
- Putative FBD-associated F-box protein At1g78730
- F-box protein At3g57590
- Putative F-box protein At4g38870
- FBD-associated F-box protein At5g56370
- F-box/kelch-repeat protein At5g43190
- Integral membrane HRF1 family protein
Sequence:
MFSEEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWKCQCAKKWPSVCKRHKPPTETYYKMYQTFSKRRLNRALPPPRLSFENLEFFIDIWSEERLVFSGLIPGVALENGIETLPLGISNVLRTHLGRPDYKMVVPAEPRFTIPLNQSVSVSVLVARNDSDKVARIINRSVFDYIDRSSYRALAFEYLDLSPCYPFISGIRAWISLLFMDVEDMNDDGLLDVFGIQLDFNDVADTKEEVLWLLDMLDWK
Protein: Placenta-specific gene 8 protein (Protein C15) (Q9NZF1)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein C10
- DNA-directed RNA polymerase III subunit RPC8
Sequence:
MQAQAPVVVVTQPGVGPGPAPQNSNWQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNECCLCGTSVAMRTLYRTRYGIPGSICDDYMATLCCPHCTLCQIKRDINRRRAMRTF
Protein: dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) (Pyruvate dehydrogenase complex component E2) (M9PCU4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRSLATTRNELGALRSVLLRSNNATYVRRSTGNVVVRALSSQLINSRKLQSIRSKLNTSQSPVTWSYNFARAYANLPEHIRVPLPALSPTMERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILIQGGTKDVPVGQLLCIIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAPAAAAPPPAPAAAPAAAGKGSGVHGSIKSGDLAGQKAAAKPAAAAPAKAPRAAGARYEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDKLLKFRAKVNKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAWMDTVIRKYDDVDVSVAVSTDKGLITPIVFNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQFAAVINPPQSCILAIGTTTKQLVADPDSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL
Protein: Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.29) (Q6SGW1)
Organism: uncultured marine bacterium 443
Interaction partners:
Sequence:
MENGLLDCEQYLEEAMAEHATAQCPPLLAQALNYAVFPGGARVRPKICKAVALANNSSDVGLANAAASAIELLHCASLVHDDLPCFDDATQRRGKPSVHAKFGERIAVLTGDALIVAAFQTLATHAIHAVRTERVPLVTAIVARGVGAPHGICAGQAWECERSVDLSRYHRAKTGALFVAATCAGAAAAGVDPGPWVNLGASIGEAYQVADDIKDAISDPETLGKPTGIDVKLDRPSAVRELGLDGAVTRLKQCLEAGLDSMPACAGQDLLQKIVRAQASRFVPEKIAQVAA
Protein: Cln7, isoform A (Cln7, isoform B) (Cln7, isoform C) (GH22722p) (Q9VS51)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Battenin
Sequence:
MEFARRVSARFETKRLPEDVDDGLETLEEYKQRWRSVRIIYFTMFLMALGFSIILTGIWPYLNKLDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLASGIYSSLELRPDNVKYWMLSSRFLIGVSSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLGDQGHVWLWGKMHFNMYTASGWINVLMSIGNFMMFLPGVFEEHKIAAREVMVMQGGTSEKETWKGIKPSYLSAWTLIVAFFVLVFNFVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEPMCKIIAERYVLIWGGFSLMFLGRVLFVPWGPDPPKLAQPFNASWNLSESDPIFLGCPTTQKWCGELPALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWLQCSNRLLIPPTFEKTTPVELKELNKHNGSKLLDDHSPDTHNGSPPEDLSPDQPILGKHGSQHSISHA