wanglab/gogpt-training-data huggingface dataset:
Protein: Salicylyl-CoA synthase / salicylate adenylyltransferase (EC 6.2.1.65) (Q7X279)
Organism: Streptomyces sp
Function: Involved in the degradation of salicylate via a pathway involving coenzyme A derivative. Catalyzes the conversion of salicylate to salicyloyl-CoA via the formation of a salicylate-adenylate intermediate. The substrate specificity is strong, since benzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, gentisate, 2-aminobenzoate, aminobenzoate, salicylamide, salicylaldoxime and 2-hydroxyphenyl acetate cannot substitute for salicylate.
Interaction partners:
Sequence:
MTREGFVPWPKEAADRYREAGYWRGRPLGSYLHEWAETYGDTVAVVDGDTRLTYRQLVDRADGLACRLLDSGLNPGDAMLVQLPNGWEFVTLTLACLRAGIAPVMAMPAHRGHELRYLAAHAEVTSIAVPDRLGDFDHQALGREVAEDTPSVGLLLVAGGTVGTDATDLRALAEPADDPVTARARLDRIAPDSGDIAVFLLSGGTTGLPKLITRTHDDYEYNARRSAEVCGLDSDSVYLVALPAGHNFPLACPGILGTLMNGGRVVLARTPEPGKVLPLMAAEGVTATAAVPAVVQRWIDAVASGRHPAPPALRLLQVGGARLAPEVARRAEPVLGGTLQQVFGMAEGLLNYTRPDDPDDIKIETQGRPMCPDDEILVVDASDNPVPPGEMGALLTRGPYTPRGYYRAAEHNARAFTPDGWYRTGDVVRLHPSGNLVVEGRDKDLINRGGEKISAEEVENLIYRLPGVARVAAVAKADPDLGERVCAVVVVEPGTQLSLESVRAALTAMQVARYKLPEDLLVVDELPLTKVGKIDKKRLRDVVRGKADSVEAV
Protein: Defensin-like protein 210 (Q2V3K4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Defensin-like protein 218
- Pollen receptor-like kinase 6
- Defensin-like protein 223
Sequence:
MKTIILFLTLLVISSSCTSIITKTMNSKETTYLDSPAVSPSIDQYLVDIHLGHSFLQGVMSFCYDCGKACFRRGKNLARCKKFVCRCTKSGIK
Protein: Transmembrane protein adipocyte-associated 1 (Integral membrane protein GPR175) (TPRA40) (Transmembrane domain protein of 40 kDa regulated in adipocytes) (Q99MU1)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Transient receptor potential cation channel subfamily A member 1
Sequence:
MASLQEANGSTAWPPPTASNISEPHQCLLLLYEDIGSSRVRYWDLLLLIPNVLFFIFLLWKLPLARAKIRVTSSPIFITFYILVFVVALVGIARAVVSMTVSASDAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDSHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERVSLPSRRSFYVYAGILATLNLLQGLGSALLCANIIVGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDEAEEPDMHLPQPYAVARREGIESAGPACASAANYSSTQFDSAGVAYLDDIASMPCHTGSINSTDSERWKAINA
Protein: Succinate-semialdehyde dehydrogenase (EC 1.2.1.24) (C9J8Q5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|RuleBase:RU365091}.
Interaction partners:
Sequence:
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Protein: Galactose-specific C-type lectin, isoform A (Galactose-specific C-type lectin, isoform B) (IP02782p) (Q9VIX1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- UPF0585 protein CG18661
- Fatty acid desaturase domain-containing protein
- Elongation of very long chain fatty acids protein
Sequence:
MLKLTVLLITLLVIAKTGWTREKFSIQVNEGNTFGALVKAEPFTKINDGYYFFGTESLNWYEAYEKCRELNSELVTFETDQEFDAVTAFLTANGSRLTYWTSGNDLAKTGSHRWFTNAQRISSLRWARNQPDNAGQKEHCIHLGYIYKDSRKFELNDRPCSQDPNSLFKYICEAPEMETISIVVWK
Protein: Acetoin utilization protein AcuA (EC 2.3.1.-) (Protein acetyltransferase AcuA) (P39065)
Organism: Bacillus subtilis (strain 168)
Function: Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue.
Interaction partners:
- Acetoin utilization protein AcuC
- Acetyl-coenzyme A synthetase
- Acetoin utilization protein AcuB
- Putative acetyltransferase BSU40680
- NAD-dependent protein deacetylase
- Putative [ribosomal protein bS18]-alanine N-acetyltransferase
- Uncharacterized acyl--CoA ligase YtcI
- Putative membrane-bound acyltransferase YfiQ
- Uncharacterized protein YqgY
- Uncharacterized membrane protein YuiB
Sequence:
MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRPPREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIEVAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMMNAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY
Protein: Thioredoxin-like protein slr1139 (P73263)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Peroxiredoxin sll1621
- Slr0600 protein
- Glutaredoxin arsenate reductase
- Rehydrin
- Probable glutaredoxin slr1562
- Thiol:disulfide interchange protein TxlA homolog
- thioredoxin-dependent peroxiredoxin
- Putative peroxiredoxin sll0755
Sequence:
MSLLEITDAEFEQETQGQTKPVLVYFWASWCGPCRLMAPAIQAIAKDYGDKLKVLKLEVDPNPAAVAQCKVEGVPALRLFKNNELVMTHEGAIAKPKLLELLKEELDFI
Protein: RNA helicase (EC 3.6.4.13) (Q5STU3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRCYPLSPSRWPEQAGLAPRAWLSHLCPMRMMPRSSMMCRIALRSILVSCLMR
Protein: Cell division protein FtsL (P0AEN4)
Organism: Escherichia coli (strain K12)
Function: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Can also mediate Zn(2+)-sensitivity probably by increasing the permeability of the inner membrane.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00910, ECO:0000269|PubMed:10027987, ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:1332942, ECO:0000269|PubMed:15165235}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_00910, ECO:0000269|PubMed:10027987, ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:1332942, ECO:0000269|PubMed:15165235}. Note=Localizes to the division septum where it forms a ring structure. Localization requires FtsZ, FtsA, ZipA, FtsK, FtsQ and FtsB, but not FtsI and FtsN. Localization of FtsB and FtsL is codependent.
Interaction partners:
- Cell division protein FtsB
- Peptidoglycan D,D-transpeptidase FtsI
- Probable peptidoglycan glycosyltransferase FtsW
- Cell division protein FtsQ
- Cell division protein FtsA
- DNA translocase FtsK
- Cell division protein FtsN
- Cell division protein ZipA
- Cell division protein FtsZ
- Ribosomal RNA small subunit methyltransferase H
Sequence:
MISRVTEALSKVKGSMGSHERHALPGVIGDDLLRFGKLPLCLFICIILTAVTVVTTAHHTRLLTAQREQLVLERDALDIEWRNLILEENALGDHSRVERIATEKLQMQHVDPSQENIVVQK
Protein: Small ribosomal subunit protein bS6c (30S ribosomal protein S6 alpha, chloroplastic) (Q8VY91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds together with S18 to 16S ribosomal RNA.
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein uL18c
- Large ribosomal subunit protein bL35c
- Large ribosomal subunit protein uL4c
- Small ribosomal subunit protein uS10c
- Large ribosomal subunit protein uL6c
- Large ribosomal subunit protein bL17c
- Large ribosomal subunit protein uL1c
- Large ribosomal subunit protein bL21c
- Small ribosomal subunit protein uS17c
Sequence:
MASSLCVSNSTICPLPNVSSQPLLSFSHSLRPFISKSKPMCASIQKRDGSQFVVKSQALDFSGTFFEGGFGSDDDPTSPSGSGVSTALEDKPEPQCPPGLRQYETMAVLRPDMSEDERLGLTQKYEELLVAGGGMYVEVFNRGVIPLAYSIRKKNKAGETNTYLDGIYLLFTYFTKPESIVPLETVLTADDDIIRSSSFKIKKRKYN
Protein: Protein STB3 homolog (Q9P7B0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Zinc finger protein sfp1
- Fork head transcription factor 1
- Uncharacterized Rab geranylgeranyltransferase C15C4.03
- RNA polymerase I-specific transcription initiation factor rrn3
Sequence:
MNIDNMDLEMTTASDFAEKKESVDVKRENPSFTNSIKALPIQSELSAMMSKDNTLNHVKQEPSDGFSSVKWASTSFDSTVTAHKEETPYSSSLGSHDSSSLPSSTNNRYSSVLKELCNTYLPSILSTYGSLPIRRLLHHLSLMLPSFNELTPTQQRRLLTRALESKKGIQFEKIGWGRWVLRDSTIPANSHPQSLPSNSIPKTEPLDTPSLSNSQERFSKSPSDGQNVRSRAKKIPSGMSAEESDELLSSSGRKTRSFNTPFSSFFASLEETPGSYTAHLGGVLSPREQTPALFTGQYPDNGVYYEEEEEEEDDNDLFDEHEYGYGTLPPFVFDEDQMLDGGESTDEEDWRAIGTEALLRKVNTKKRRPSRVLVHRDQVAVEAMLMLSGSV
Protein: CSD domain-containing protein (Q583D7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLFHPTVCTHDGVLVASLNTVNPLTASTSAPLSTSPGPQPLMALPSRQLIRVTRADGPFAKLTSPPPPHSQGSVPSTSLNLNGSAPSAQPTNAGSPAVFHSVEKLLIAGGNAGNAFPLHPQHPQYHSLGGGGGISGPGNASPMPPATVSPCPWNLMPPPPSPSVYVVLSHGSTPAALQPGVALAPAPPPPPPPPIAAVVSRHGNGMMYGLGEWYEGIVKRYNPMRGFGFLTATHHLQVTSPSGGSGTFSDGNADGRSQQQQQTTPPQPTLERTPVAVGDVFVHQSYIRMHGFRALSAGDRVAFRVGKLPGKDANQAVSVQLLATARPVLPSTPAGEGEEARVSSSEVVQAVPSEFFLPQDLKDQKCGVFENGYDAEGCDDFGGDITHSSIPMEHVGASIAEQFASDAGVVPEAPLNDISDVDYDNAGQTNITSGRDINGDGCQVERADDVVTQCHNLSFTAPSDDVATISESANLGVDAKVTASWGFSATNINGHRPFGSFDDN
Protein: Uncharacterized transporter YebQ (P76269)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MPKVQADGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVISLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQMLTLARVIQGFGGAALMSVNTALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLLAMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFAQGQSLTLIAAELVVMVVVGIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVLGRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPADINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALMLNQFGDNGTHVSLMAAAILAVIAACVSGLRITQPRSRA
Protein: Myelin-associated oligodendrocyte basic protein (Q9D2P8)
Organism: Mus musculus (Mouse)
Function: May play a role in compacting or stabilizing the myelin sheath possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.
Subcellular location: Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin. {ECO:0000250}.
Interaction partners:
- Myelin-oligodendrocyte glycoprotein
- Myelin-associated glycoprotein
- Myelin basic protein
- Myelin proteolipid protein
- Ermin
- Opalin
- Methyl-CpG-binding protein 2
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
- NK6 homeobox 2
- Claudin-11
Sequence:
MSQKMAKEGPRLSKNQKFSEHFSIHCCPPFTFLNSKREIVDRKYSICKSGCFYQKKEEDWICCACQKTSRRATSPQRPKHQPAASPVVVRAPPAKPKSPLMPAKPRSPPRPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKQPARSSPLRGPGTSRGGSPTRAPRFW
Protein: Lipopolysaccharide-binding protein (LBP) (Q63313)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P18428}. Cytoplasmic granule membrane {ECO:0000250|UniProtKB:P17213}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250|UniProtKB:P17213}.
Interaction partners:
- Toll-like receptor 4
- Bactericidal permeability-increasing protein
Sequence:
MKSATGPLLPTLLGLLLLSIPRTQGVNPAMVVRITDKGLEYAAKEGLLSLQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQSCQLRGSSLKPLPGRGLSLSISDSSISVRGKWKVRRSFVKLHGSFDLDVKSVTISVDLLLGVDPSERPTVTASGCSNRIRDLELHVSGNVGWLLNLFHNQIESKLQKVLESKICEMIQKSVTSDLQPYLQTLPVTADIDTILGIDYSLVAAPQAKAQTLDVMFKGEIFNRNHRSPVTTPTPTMSLPEDSKQMVYFAISDQAFNIATRVYHQAGYLNFTITDDMLPPDSNIRLNTKAFRPFTPLITRKYPDMNLELLGTVVSAPLLNVSPGNLSLAPQMEIEGFVILPSSARESVFRLGVVTNVFVSLTFDNSKVTGMLHPEKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNDELAKGFPLPLPRRIKLHDLDFQIHKNFLYLGANVQYMRV
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (A0A087WXR7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTFFGVKNKKKIGKV
Protein: Germacrene A hydroxylase (EC 1.14.14.95) (Germacrene A oxidase) (CiGAO) (D5JBW8)
Organism: Cichorium intybus (Chicory)
Function: Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Catalyzes three consecutive oxidations of germacrene A to produce germacrene A acid. Could also catalyze the three-step oxidation of non-natural substrate amorphadiene to artemisinic acid. Can use beta-elemene as substrate.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|Ref.3}; Single-pass type II membrane protein {ECO:0000269|Ref.3}. Microsome membrane {ECO:0000269|Ref.3}; Single-pass type II membrane protein {ECO:0000269|Ref.3}.
Interaction partners:
Sequence:
MELSLTTSIALATIVLILYKLATRPKSNKKRLPEASRLPIIGHMHHLIGTMPHRGVMELARKHGSLMHLQLGEVSTIVVSSPKWAKEILTTYDITFANRPETLTGEIIAYHNTDIVLAPYGEYWRQLRKLCTLELLSVKKVKSFQSIREEECWNLVKEVKESGSGKPISLSESIFKMIATILSRAAFGKGIKDQREFTEIVKEILRQTGGFDVADIFPSKKFLHHLSGKRARLTSIHKKLDTLINNIVAEHHVSTSSKANETLLDVLLRLKDSAEFPLTADNVKAIILDMFGAGTDTSSATVEWAISELIRCPRAMEKVQAELRQALNGKEQIHEEDIQDLPYLNLVIRETLRLHPPLPLVMPRECREPVNLAGYEIANKTKLIVNVFAINRDPEYWKDAEAFIPERFENNPNNIMGADYEYLPFGAGRRMCPGAALGLANVQLPLANILYHFNWKLPNGASHDQLDMTESFGATVQRKTELILVPSF
Protein: ADP/ATP translocase (ADP,ATP carrier protein) (Q5ZMJ6)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU368008}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU368008}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Uncharacterized protein.
- Uncharacterized protein.
- Uncharacterized protein.
- Peptidyl-prolyl cis-trans isomerase D
- Peptidyl-prolyl cis-trans isomerase
- ADP/ATP translocase
- Translocase of inner mitochondrial membrane 22.
- Uncharacterized protein
Sequence:
MSDQALSFLKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITAEKQYKGIIDCVVRIPKEQGIISFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGVSEREFTGLGDCIVKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQSVTAAAGLVSYPFDTVRRRMMMQSGRKGADIMYKGTIDCWKKIAKDEGSKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV
Protein: UPF0441 protein YgiB (P0ADT2)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Putative acid--amine ligase YgiC
- Putative acid--amine ligase YjfC
Sequence:
MKRTKSIRHASFRKNWSARHLTPVALAVATVFMLAGCEKSDETVSLYQNADDCSAANPGKSAECTTAYNNALKEAERTAPKYATREDCVAEFGEGQCQQAPAQAGMAPENQAQAQQSSGSFWMPLMAGYMMGRLMGGGAGFAQQPLFSSKNPASPAYGKYTDATGKNYGAAQPGRTMTVPKTAMAPKPATTTTVTRGGFGESVAKQSTMQRSATGTSSRSMGG
Protein: thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Q9V3Q4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Death-associated inhibitor of apoptosis 1
- Peroxiredoxin-5
- Sulfiredoxin
Sequence:
MSKYLSVLLLSAALVGAAKPEDNESCYSFAGGSVYPDQPKGDHQLQYTKAVISKPAPQFEGTAVVNKEIVKLSLSQYLGKYVVLLFYPLDFTFVCPTEIIAFSDRIAEFKKIKTEVIGVSVDSHFTHLAWINTPRKEGGLGDVKIPLLSDLTHKISKDYGVYLESSGHALRGLFIIDQTGVLRQITMNDLPVGRSVDETIRLVQAFQYTDTHGEVCPAGWRPGADTIVPNPEEKTKYFAKNN
Protein: Dual specificity protein kinase splB (EC 2.7.10.2) (Non-receptor tyrosine kinase spore lysis B) (Tyrosine-protein kinase 2) (P18161)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Signal transducer and activator of transcription C
Sequence:
MGITSSKPVSGSNTTTNSPTNQKAISEKKQKPKRTNKRNLSTDSKSSTCSSPTNNYLADELVVDLNSMEIEGADSIQYSGHSHSSSMTNSMTNSMRNSANEKQLQQKQQQPQQQPQQQQPQPHQSHDDLNSSALDQDDGEFNNNFENESEVESISSSSINNNNTNNNSNNNNNNNNNNNNNNNNNNNIPSISNISNNNINNNINNNNNNNSCKQKNSKNKKNKNKNNNNKNSSSSNERPYSISYDNEGSTTKSNSTLSLYSNISNLHSITSHSIQDASIVCENCNHHMTKPIHLLSLSLEPTSAASLDIHRNGNFSITLASNSRSSSPATILQQNNKHFLINSNINIINTSLNNNNKNKDEDNVNNNNGNNSNNNNNINNNNDEDNDEDNDENNNNNNNNNNNNNNNNNNNNNNTSNNDIPDLSWTNYNSDSFNNNNNNNNIFNTFLSISSPISDQQNTSPQIQEIISPLPSPPTVQQSDVIQQTTTTSPSPLPSPQKQKQQQQRPLQKSSPPPTTITTSTTTTTQFNNNNLASSLGSTSDLFNKSLISSFLNGQGISSINNSNPFENSYKNQINSSTNSGTNTFSNTNTNINTTNSSNTNVGYDQYSFNYSNGSNSNINNSNNGLKSFLSNSNSSFSALKNCSYDAKDMSSFTITLSNSELNTMIAESLNRSSASNSIVKSSNTVHTTSGGNNSLCSDGYNQNIISATTNTNTTTTNSSSTTTTTTATTTTASTTNNNINNNNNNSTSTTNSTKDITFLVCDNPDSTKEKSNVSNTSSIISASNLNRHITPNSHMRPRGRSISESLIMSPINKESLNDIQRAIESEKIKKTKFEELKSILGEREYIIDINDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLKIIGDEEQFKERFIREVQNLKKGNHQNIVMFIGACYKPACIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLHSITIVHRDLTSQNILLDELGNIKISDFGLSREKSREGSMTMTNGGICNPRWRPPELTKNLGHYSEKVDVYCFSLVVWEILTGEIPFSDLDGSQASAQVAYAGLRPPIPEYCDPELKLLLTQCWEADPNDRPPFTYIVNKLKEISWNNPIGFVSDQFYQYSEPSTPRLALSNQSSNSSSISLSPTKL
Protein: Phosphatidylethanolamine binding protein 2 (M0RB80)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Large ribosomal subunit protein mL40
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL10m
- Mitochondrial ribosomal protein L44.
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein uS10m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL13m
Sequence:
MPADITVWAGPLSLQDVDEQPQHLLRVTYAGAEVSELGQVLTPTQVKNRPSSITWDGLDPGKLYTLILTDPDAPSRKEPIYREWHHFLVVNMKGNDISSGKVLSDYVGSGPPKGTGLHRYVWLVYQQDKPLKCDEPILTNRSGNQRGKFKAAAFRKKYHLGAPVAGTCYQAEWDSYVPKLYKQLSGK
Protein: Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (Q9R1C6)
Organism: Mus musculus (Mouse)
Function: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (By similarity). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P52429}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P52429}.
Interaction partners:
- Lipoprotein lipase
- Dihydroxyacetone phosphate acyltransferase
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Phosphatidate cytidylyltransferase 2
- Phospholipase D1
- Phospholipase D2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
- Diacylglycerol O-acyltransferase 1
- Cyanocobalamin reductase / alkylcobalamin dealkylase
Sequence:
MEGDQRSGPPAQSLLPDGHLVLWTLCSVLLPVFITLWCSLQRSRRQLHRRDIFRKSKHCWRDTDLFSHPTYCCVCAQHILQGAFCDCCGLRVDEGCLKKVDKRFPCKEIMLKNDKAADAMPHHWIRGNVPLCSYCVFCRQQCGSQPKLCDYRCIWCQKTVHDECMRGSLRSEKCDFGEFRNLIIPPSYLTSINQMRKDKNTNYEGLASKFGKQWTPLIILANSRSGTNMGEGLLGEFKILLNPVQVFDVTKTPPIKALQLCTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKIELELDGERVELPNLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEIVGVYGSFHCAQIQVKLANPFRIGQAHTVRLTLKCSMMPMQVDGEPWAQGPCTVTITHKTHALMLYFSGEQSDDDISSPSDHEDVKEAE
Protein: GRAM domain-containing protein 4 (Death-inducing protein) (Q6IC98)
Organism: Homo sapiens (Human)
Function: Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CB44}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with COX4I1. {ECO:0000269|PubMed:15565177}.
Interaction partners:
Sequence:
MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS
Protein: DENN domain-containing protein 5B (Rab6IP1-like protein) (Q6ZUT9)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFKSARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDFTIVLEGSLIKGVDV
Protein: Bonus, isoform B (RE48191p) (A8WHL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDMDLEQLKNDFLPLIAGIKQEQLDAVPTDALPQMSTPNTASGAPTTSSLSSSSLSLSNPCDSAEKRSESNSSASAKFTLFKCVYCAQLLGSNDRPKLLECLHVACAQCVSTKFSELDRSLPPLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPNGTPQPQHPPRQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSVRFGGMPPVGMQRHGQPHVSSSTHPQNMDISLRGLLNNQAAQSPNAHMAFNGPPSYPGGPQGAPAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNSLGFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNPKTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVLPEGRTKTTSPQVHSSTDLSNTQEVNNKNEQKDDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTEGSEKSSSGELSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGKRNTSNSPALLGVNATGSPSPIENGRKSCGSASLGDSDGACLPAKRARRSAHE