wanglab/gogpt-training-data huggingface dataset:
Protein: Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1 homolog) (O35815)
Organism: Rattus norvegicus (Rat)
Function: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity).
Subcellular location: Nucleus matrix {ECO:0000250|UniProtKB:P54252}. Nucleus {ECO:0000250|UniProtKB:P54252}. Lysosome membrane {ECO:0000250|UniProtKB:P54252}; Peripheral membrane protein {ECO:0000250|UniProtKB:P54252}. Note=Predominantly nuclear, but not exclusively, inner nuclear matrix. Recruited to lysosomal membrane in response to amino acid deprivation by the RagA/RRAGA-RagB/RRAGB complex. {ECO:0000250|UniProtKB:P54252}.
Interaction partners:
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Transitional endoplasmic reticulum ATPase
- E3 ubiquitin-protein ligase parkin
- Beclin-1
- Ataxin 2
- Forkhead box O4
- RAD23 homolog A, nucleotide excision repair protein.
- Ataxin 2-like
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
Sequence:
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERLRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIKVQQMHRPKLIGEELAHLKEQSALKADLERVLEAADGPGMFDDDEDDLQRALAMSRQEIDMEDEEADLRRAIQLSMQGSSRGMCEDSPQTSSTDLSSEELRKRREAYFEKQQHQQQEADRPGYLSYPCERPTTSSGGLRSNQAGNAMSEEDVLRATVTVSLETAKDSLKAERKK
Protein: TLD-domain containing nucleolar protein (Q9AT60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein PROTON GRADIENT REGULATION 5
- Probable NAD
Sequence:
MHALKDKVSQKLSNLFADSPSQSASPRYSNSDSPKARLNSSVGKSLSSYFSFVVPQSGNEEDSELCPPLPIRTESYECIENCKSANGQAKAGTFISIGEDKDCELRVSAKVEESGNDYFDGVKKMRELTESSVFITANLFEFLHASLPNIVRGCKWILLYSTLKHGISLRTLLRRSGELPGPCLLVAGDKQGAVFGALLECPLQPTPKRKYQGTSQTFLFTTIYGEPRIFRPTGANRYYLMCMNEFLAFGGGGNFALCLDEDLLKATSGPSETFGNECLASSTEFELKNVELWGFAHASQYLS
Protein: U6 snRNA-associated Sm-like protein LSm4 (Q6QA18)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365049}.
Interaction partners:
Sequence:
MSVRKPITPLDVLRNCRAKVVSVELAGGETINGTVVRVDRAMNMVLKQCIRTSADGEAFWRSRESLIRGASVRNVRMDERAVIIADAQLREVTSKSKNKNRVKAKSNDKQQGERKATLSGEKRNRGK
Protein: Glutathione-regulated potassium-efflux system ancillary protein KefG (Putative quinone oxidoreductase KefG) (EC 1.6.5.2) (P0A756)
Organism: Escherichia coli (strain K12)
Function: Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01415}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01415}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01415}.
Interaction partners:
- Glutathione-regulated potassium-efflux system protein KefB
- Glutathione-regulated potassium-efflux system protein KefC
- Uncharacterized protein YheV
Sequence:
MMSQPAKVLLLYAHPESQDSVANRVLLKPATQLSNVTVHDLYAHYPDFFIDIPREQALLREHEVIVFQHPLYTYSCPALLKEWLDRVLSRGFASGPGGNQLAGKYWRSVITTGEPESAYRYDALNRYPMSDVLRPFELAAGMCRMHWLSPIIIYWARRQSAQELASHARAYGDWLANPLSPGGR
Protein: cAMP-dependent protein kinase inhibitor beta (PKI-beta) (Q9C010)
Organism: Homo sapiens (Human)
Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Interaction partners:
Sequence:
MRTDSSKMTDVESGVANFASSARAGRRNALPDIQSSAATDGTSDLPLKLEALSVKEDAKEKDEKTTQDQLEKPQNEEK
Protein: Proteasome subunit alpha type-6-A (20S proteasome subunit alpha A-1) (Proteasome component 1) (Proteasome subunit alpha type-1) (O81146)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-6
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-3-A
- Proteasome subunit beta type-2-B
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3-B
- Proteasome subunit alpha type-5-B
- Proteasome subunit alpha type-4-A
- Proteasome subunit alpha type-1-B
Sequence:
MSRGSGAGYDRHITIFSPEGRLFQVEYAFKAVKTAGITSIGVRGKDSVCVVTQKKVPDKLLDQSSVTHLFPITKYIGLVATGITADARSLVQQARNQAAEFRFTYGYEMPVDILAKWIADKSQVYTQHAYMRPLGVVAMVMGVDEENGPLLYKCDPAGHFYGHKATSAGMKEQEAVNFLEKKMKENPSFTFDETVQTAISALQSVLQEDFKATEIEVGVVRAENPEFRALTTEEIEEHLTAISERD
Protein: ATMYB2 (At2g47190) (MYB transcription factor) (Myb domain protein 2) (Q39028)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcription factor MYC2
- Calmodulin-1
- Calmodulin-7
- Calmodulin-6
- BURP domain protein RD22
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
- Calcium-binding protein CP1
- Calmodulin-2
- Calmodulin-like protein 10
- Dehydration-responsive element-binding protein 2A
Sequence:
MEDYERINSNSPTHEEDSDVRKGPWTEEEDAILVNFVSIHGDARWNHIARSSGLKRTGKSCRLRWLNYLRPDVRRGNITLEEQFMILKLHSLWGNRWSKIAQYLPGRTDNEIKNYWRTRVQKQAKHLRCDVNSNLFKETMRNVWMPRLVERINAQSLPTTCEQVESMITDPSQPVNEPSPVEPGFVQFSQNHHQQFVPATELSATSSNSPAETFSDVRGGVVNGSGYDPSGQTGFGEFNDWGCVGGDNMWTDEESFWFLQDQFCPDTTSYSYN
Protein: Elongation factor 3B (EF-3B) (EC 3.6.4.-) (Eukaryotic elongation factor 3B) (eEF3) (Homolog of EF-3) (Translation elongation factor 3B) (P53978)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ribosome-dependent ATPase that promotes the translation of proteins required for detoxification of reactive oxygen species. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P16521}.
Interaction partners:
- Serine/threonine-protein kinase TOR1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL13A
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS15
Sequence:
MSDSQQSITVLEELFRKLETATSETREGISSELSSFLNGNIIEHDVPEVFFDEFQKAIQSKQKALNTLGAVAYIANETNLSPSVEPYIVATVPSVCSKAGSKDNDVQLAATKALKAIASAVNPVAVKALLPHLIHSLETSNKWKEKVAVLEVISVLVDAAKEQIALRMPELIPVLSESMWDTKKGVKEAATTTITKATETVDNKDIERFIPKLIECIANPNEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLAERETSIKRKAAVIIDNMCKLVEDPQVVAPFLGKLLPGLKNNFATIADPEAREVTLKALKTLRRVGNVGEDDVLPEISHAGDVSTTLGVIKELLEPEKVAPRFTIVVEYIAAIAANLIDERIIDQQTWFTHVTPYMTIFLHEKTAKEILDDFRKRAVDNIPVGPNFQDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRGRRYGLCGPNGAGKSTLMRSIANGQVDGFPTQDECRTVYVEHDIDNTHSDMSVLDFVYSGNVGTKDVITSKLKEFGFSDEMIEMPIASLSGGWKMKLALARAVLKDADILLLDEPTNHLDTVNVEWLVNYLNTCGITSVIVSHDSGFLDKVCQYIIHYEGLKLRKYKGNLSEFVQKCPTAQSYYELGASDLEFQFPTPGYLEGVKTKQKAIVKVSNMTFQYPGTTKPQVSDVTFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRVAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGELIESHSKMVAEIDMKEALASGQFRALTRKEIELHCAMLGLDSELVSHSRIRGLSGGQKVKLVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLTDEVWAVKDGKMTPSGHNWVAGQGAGPRIEKKEEEGDKFDAMGNKINSGKKKSKLSSAELRKKKKERMKKKKEMGDEYVSSDEDF
Protein: Photosystem II reaction center protein T (PSII-T) (P61839)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Seems to play a role in the dimerization of PSII.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00808}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00808}.
Interaction partners:
- Cytochrome b559 subunit alpha
- Photosystem II protein D1
- Photosystem II CP47 reaction center protein
- Photosystem II reaction center protein H
- Cytochrome b559 subunit beta
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II reaction center protein I
- Photosystem II reaction center protein L
- Photosystem II D2 protein
Sequence:
MEALVYTFLLVSTLGIIFFAIFFREPPKISTKK
Protein: Tobamovirus multiplication protein 1 (NtTOM1) (Q402F4)
Organism: Nicotiana tabacum (Common tobacco)
Function: Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:12514140}; Multi-pass membrane protein {ECO:0000269|PubMed:12514140}.
Interaction partners:
- ADP-ribosylation factor-like 8a
Sequence:
MTRLPLGSSSIDIAGPTTNWWDQINESVQWQDGIFYSLCASYALVSAVALIQLIRIELRVPEYGWTTQKVFHLMNFVVNGVRAIVFGFHKQVFLFHPKVLSLAILDLPGLLFFSTFTLLVLFWAEIYHQARSLPTDKLRISYISINGAIYFIQACIWVYLWSNDNSTVEFIGKIFIAVVSFIAALGFLLYGGRLFLMLRRFPIESKGRRKKLHEVGSVTAICFTCFLISCFVVVLSAFDPDASLDVLDHPVLNLIYYLLVEILPSALVLYILRKLPPKRVSAQYHPIS
Protein: C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2) (Q9JL99)
Organism: Mus musculus (Mouse)
Function: C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Podoplanin
- Tyrosine-protein kinase SYK
- Platelet glycoprotein VI
- von Willebrand factor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Platelet glycoprotein Ib alpha chain
- Lymphocyte cytosolic protein 2
- Prothrombin
- P-selectin
- C-type lectin domain family 4 member G
Sequence:
MQDEDGYITLNIKPRKQALSSAEPASSWWRVMALVLLISSMGLVVGLVALGIMSVTQQKYLLAEKENLSATLQQLAKKFCQELIRQSEIKTKSTFEHKCSPCATKWRYHGDSCYGFFRRNLTWEESKQYCTEQNATLVKTASQSTLDYIAERITSVRWIGLSRQNSKKDWMWEDSSVLRKNGINLSGNTEENMNCAYLHNGKIHPASCKERHYLICERNAGMTRVDQLL
Protein: Stringent starvation protein B (Q9A6J2)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- UPF0335 protein CC_3319
- DUF1013 domain-containing protein
- Outer membrane protein assembly factor BamE domain-containing protein
- NADH:ubiquinone oxidoreductase subunit NDUFA12
- DnaJ-related protein
- ATP synthase subunit b
- Thioesterase domain-containing protein
- Peptidase C13
- Septum formation initiator
- PD-
Sequence:
MSQTEPPEDLMQYEAMAQDALRGVVKAALKKAAAPGGLPEPHHLYITFKTKAAGVSGPQDLLSKYPDEMTIVLQHQYWDLAPGETFFSVTLKFGGQPKRLSVPYAALTRFYDPSVQFALQFSAPEIIEDEPEPDPEPEDKANQGASGDEGPKIVSLDQFRKK
Protein: Ubiquitin-like domain-containing protein (Q582T9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Enoyl-CoA hydratase/isomerase domain-containing protein
- Small ribosomal subunit protein mS41
- Uncharacterized protein
- Uncharacterized protein
- Pentacotripeptide-repeat region of PRORP domain-containing protein
- Ribosomal protein S9
- LysM domain-containing protein
- Opioid growth factor receptor
Sequence:
MRRGALSLLKAGLLGHYQQEAFEARKRFEESTTYPGPIRAATPGDTRFYSGSLESILHDTDRHYWRAVTDDPRVQHLIPLRIRFKIFTWVTSGWEQRMQVVQIMAPKDSTIAQVKDLVLVENQSPYLCVSSFHLAIDGKELDPQKTLGEYGVTEQSQIDAIEQNDHLLHRDDERPRDWTVDEITAEDVKRSPYKEMEMQPLQNLAPRYEARPKGYFGRTYYSGMKQSS
Protein: Skywalker, isoform K (M9PDV9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MPYHRGGDASSQADKLSGIVEESDLYEGFAPHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIREGEKSPGHRAIAMGVYPIHNLKSQACKNEDLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYGFVGI
Protein: Serine/threonine-protein kinase SRK2F (EC 2.7.11.1) (OST1-kinase-like 5) (SNF1-related kinase 2.7) (SnRK2.7) (Q9SMQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable protein phosphatase 2C 78
- Protein phosphatase 2C 37
- Protein phosphatase 2C 3
- Probable protein phosphatase 2C 24
- Protein phosphatase 2C 16
- Probable protein phosphatase 2C 75
- Protein phosphatase 2C 7
- Protein phosphatase 2C 56
- Protein phosphatase 2C 77
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
Sequence:
MERYDILRDLGSGNFGVAKLVREKANGEFYAVKYIERGLKIDEHVQREIINHRDLKHPNIIRFKEVFVTPTHLAIVMEYAAGGELFERICNAGRFSEDEGRYYFKQLISGVSYCHAMQICHRDLKLENTLLDGSPSSHLKICDFGYSKSSVLHSQPKSTVGTPAYVAPEVLSRKEYNGKIADVWSCGVTLYVMLVGAYPFEDPEDPRNIRNTIQRILSVHYTIPDYVRISSECKHLLSRIFVADPDKRITVPEIEKHPWFLKGPLVVPPEEEKCDNGVEEEEEEEEKCRQSVEEIVKIIEEARKGVNGTDNNGGLGLIDGSIDLDDIDDADIYDDVDDDEERNGDFVCAL
Protein: Beta-hexosaminidase Amuc_2018 (EC 3.2.1.52) (Beta-N-acetylhexosaminidase Am2301) (B2UP57)
Organism: Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)
Function: Hydrolyzes terminal GlcNAc residues from terminally unbranched N-glycans and from chitobiose. Hydrolyzes beta-1,6-linked N-acetylglucosamine and beta-1,4-linked N-acetylgalactosamine from pNP-alpha-GalNAc[beta1,3Gal]beta1,6GlcNAc and pNP-beta-GlcNAc-beta1,4-GalNAc substrates, respectively, as well as beta-1,2-linked N-acetylglucosamine units from the non-reducing end of N-glycans. Hydrolyzes GlcNAc residues linked to alpha1,3- or alpha1,6-mannose branch, but has low activity on substrates with more than one GlcNAc residue on one of the mannose branches. Releases terminal GlcNAc moieties from the N-glycopeptide Gly-Glu-Asn-(GlcNAc2Man3GlcNAc2)-Arg with high efficiency. Has moderate hydrolytic activity on the chitobiose moiety of N-glycopeptide substrate Gly-Glu-Asn-(GlcNAc2)-Arg. Does not hydrolyze GlcNAc residues from N-glycan structures bearing a bisecting GlcNAc moiety (beta1,4-linked GlcNAc to the beta1,4-linked core mannose). Potentially capable of cleaving the specific glycoside linkages in the process of mucin degradation in human intestinal tract (Probable). Hydrolyzes synthetic substrate pNP-beta-GlcNAc with high activity and pNP-beta-GalNAc to a lesser extent. Does not hydrolyze pNP-beta-glucose, pNP-beta-galactose, pNP-alpha-glucose, pNP-alpha-galactose, pNP-alpha-GlcNAc or pNP-alpha-fucose.
Interaction partners:
- Aminoglycoside phosphotransferase
- N-acylglucosamine 2-epimerase
Sequence:
MARPLPILGGILLSFSPPAEATAQYSIIPEPSRTELRQETAKTLQLLSDQEVPTLETDAYRLTVTPQGAHLASGGREGRIYGLATLRQLRDQLAGQPEGIPCGVITDKPRYPWRGLMVDPARHFIPAADLKKFVDMMAYYKFNRLHLHLTDNQGWRLPVPGYPKLKSVASRREESFGDGIPHEGMYTKQELKELVAYCAARGIDVIPEIDMPGHNQALHAAYPEFFCFPKPDMNVRTTAGNSKELVCPQKPEVWKFYASVFNELKDIFPSGIVHLGGDEAPTELWEKCPLCREARTRAAMKDEQEQMKAFFAKTAALLAKNGQTPQFWYEGNAGIYHPGETVYAWRQGQALQSIEKTKKAGLNLIMASSEYCYLDFPQIQGQRNWGWMKTTTLQKCYDLDPAFGKPEKEAGHIRGVHAPVWAERLPDLNHLLYRAYPRACAIAEAGWSPMGVRSWENFRRKLADHRQFILKRFNYDMERTQGNEPAFRWENNK
Protein: Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) (O75223)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Interaction partners:
- Glutathione hydrolase 1 proenzyme
- 5-oxoprolinase
- Glutathione-specific gamma-glutamylcyclotransferase 1
- Glutathione-specific gamma-glutamylcyclotransferase 2
- Glutathione hydrolase 7
- Glutathione hydrolase 6
- Glutathione hydrolase 5 proenzyme
- Glutathione synthetase
- Glutamate--cysteine ligase catalytic subunit
- Glutamate--cysteine ligase regulatory subunit
Sequence:
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL
Protein: Protein FAM3A (Cytokine-like protein 2-19) (P98173)
Organism: Homo sapiens (Human)
Function: May act as a defensin against invading fungal microorganisms.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Sorting nexin-15
Sequence:
MRLAGPLRIVVLVVSVGVTWIVVSILLGGPGSGFPRIQQLFTSPESSVTAAPRARKYKCGLPQPCPEEHLAFRVVSGAANVIGPKICLEDKMLMSSVKDNVGRGLNIALVNGVSGELIEARAFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKLFSELGSRNAKELAFRDSWVFVGAKGVQNKSPFEQHVKNSKHSNKYEGWPEALEMEGCIPRRSTAS
Protein: Dusky-like, isoform A (Dusky-like, isoform B) (Dusky-like, isoform C) (FI19835p1) (Q9VZE0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI03362p
- LP17541p
- LD17368p
- LD24139p
- RE59626p
- Osiris 15
- FI01546p
- Uncharacterized protein, isoform B
- LD45449p
- Ecdysone-inducible gene L1, isoform B
Sequence:
MGHLTRRSSLMAIVLCLVLNTQHLSVHGDASHIESAALPLEHRAGYGPPAPIYGAPQGPLSTGATNDVSEEAWPLASTNDSPQIKHLQVQCEKTHMRVNIEFDRPFYGMIFSKGFYSDPHCVHLKPGTGHLSATFEIFLNSCGMTSSANHNAAGYGAPTPSGSYVENTIIIQYDPYVQEVWDQARKLRCTWYDFYEKAVTFRPFQVDMLHAVTANFLGDNLQCWMQIQVGKGPWASEVSGIVKIGQTMTMVLAIKDDENKFDMLVRNCVAHDGKRAPIQLVDQNGCVVRPKIMSKFQKIKNFGPSASVVSFAYFQAFKFPDSMNVHFQCVIQVCRYNCPEPKCGPGLPGGEYGLPQIGANGLSEEYGPPEAYERNDFALGGPGVLPPAAYPDPRHPASDATGAYSENQPDVVPSPQAQTSAAVPTADSGTVSGPASSQSPQPQPTGSNELGLPPPPLPGQSGQYSTVKRKDDLSAGGNLVSLGGRPRSVEGLDDLRGVRRRRDTMDIVVKPQRIYKRNAQEMTDVNTSRIIQVVAPGDVNFALNSNASNETVVIQSARSADAETICMSVPSFVGGLVMLLLVLAVASLVAAFLFVRVRHFDRKGAGMAYVN
Protein: Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) (P78368)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:26481050}.
Interaction partners:
- Ceramide transfer protein
- Beta-adrenergic receptor kinase 1
- Protein smoothened
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- G protein-coupled receptor kinase 3
- Casein kinase I isoform gamma-1
- Casein kinase I isoform gamma-3
- Axin-1
Sequence:
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
Protein: Calcium-dependent protein kinase 23 (OsCDPK23) (OsCPK23) (EC 2.7.11.1) (Calcium-dependent protein kinase isoform 1) (CDPK1) (Seed-specific protein kinase) (P53682)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Involved in the activation of sucrose synthase 2 (SUS2) in developing seeds. Phosphorylates SUS2 at Ser-10 in a calcium-dependent manner. Phosphorylation of Ser-10 leads to the activation of SUS2, which supplies substrates for the biosynthesis of storage products in immature seeds.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Respiratory burst oxidase homolog protein B
- Os12g0541300 protein
- Os09g0438000 protein.
- Os11g0537400 protein
- Serine/threonine-protein phosphatase BSL1 homolog
Sequence:
MGNSCQNGTYGNNYQNSNRFQNDRFASRYVDGNDTEDCYSGSSRASLAGALRQGLNLKSPVLGYKTPNVRELYTLGRELGQGQFGKTYLCTEISTGCQYACKTILKSNLRCVSDIEDVRREIQIMHHLSGQKNIVTIKDTYEDEQAVHIVMELCAGGELFSKIQKRGHYSERKAAELIKIIVGIIETCHSHGVMHRDLKPENFLLLDADDEFSVKAIDFGLSVFFRPGQVFREVVGSPYYIAPEVLEKRYGPEADIWTAGVILYVLLTGVPPFWADTQSGIYEKVLDGRIDFKSNRWPRISDSAKDLIKKMLCPYPSERLKAHEVLKHPWICDNGVATNRALDPSVLPRLKQFSAMNRLKKLSLQIIAERLSEEEIVGLREMFKAMDTKNRSVVTFGELKGLKRYSSVFKDTEINDLMEAADDTTSTINWEEFIAAAVSLNKIEREKHLMAAFTYFDKDGSGFITVDKLQKACMERNMEDTFLEEMILEVDQNNDGQIDYAEFVTMMQSNNFGLGWQTVESSLNVALREAPQVY
Protein: Cytochrome b5 isoform E (AtCb5-E) (Cytochrome b5 isoform 1) (Cytochrome b5 isoform A) (AtCb5-A) (Q42342)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases, including fatty acid desaturases.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22773744}; Single-pass membrane protein {ECO:0000269|PubMed:22773744}.
Interaction partners:
- NADH--cytochrome b5 reductase 1
- NADH-cytochrome b5 reductase-like protein
- Bax inhibitor 1
- Very-long-chain aldehyde decarbonylase CER1
- Dihydroceramide fatty acyl 2-hydroxylase FAH1
- Probable lysophospholipase BODYGUARD 1
- Dihydroceramide fatty acyl 2-hydroxylase FAH2
- Probable steroid-binding protein 3
- Sucrose transport protein SUC4
- Very-long-chain aldehyde decarbonylase CER3
Sequence:
MSSDRKVLSFEEVSKHNKTKDCWLIISGKVYDVTPFMDDHPGGDEVLLSSTGKDATNDFEDVGHSDTARDMMDKYFIGEIDSSSVPATRTYVAPQQPAYNQDKTPEFIIKILQFLVPILILGLALVVRHYTKKD