wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear RNAi defective-3 protein (Q21691)
Organism: Caenorhabditis elegans
Function: Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18653886, ECO:0000269|PubMed:34365510}. Nucleus {ECO:0000269|PubMed:18653886, ECO:0000269|PubMed:34365510}. Note=siRNA binding is necessary and sufficient for distribution of nrde-3 to the nucleus. {ECO:0000269|PubMed:34365510}.
Interaction partners:
- Nuclear exosome regulator NRDE2
- DEAD-box ATP-dependent RNA helicase rde-12
- Piwi domain-containing protein
- DRBM domain-containing protein
- Argonaute protein hrde-1
- ANK_REP_REGION domain-containing protein
- Dynein regulatory complex subunit 7
- RNA-directed RNA polymerase
- RNA-directed RNA polymerase
- Hyaluronan/mRNA-binding protein domain-containing protein
Sequence:
MDLLDKVMGEMGSKPGSTAKKPATSASSTPRTNVWGTAKKPSSQQQPPKPLFTTPGSQQGSLGGRIPKREHTDRTGPDPKRKPLGGLSVPDSFNNFGTFRVQMNAWNLDISKMDERISRIMFRATLVHTDGRRFELSLGVSAFSGDVNRQQRRQAQCLLFRAWFKRNPELFKGMTDPAIAAYDAAETIYVGCSFFDVELTEHVCHLTEADFSPQEWKIVSLISRRSGSTFEIRIKTNPPIYTRGPNALTLENRSELTRIIEAITDQCLHNEKFLLYSSGTFPTKGGDIASPDEVTLIKSGFVKTTKIVDRDGVPDAIMTVDTTKSPFYKDTSLLKFFTAKMDQLTNSGGGPRGHNGGRERRDGGGNSRKYDDRRSPRDGEIDYDERTVSHYQRQFQDERISDGMLNTLKQSLKGLDCQPIHLKDSKANRSIMIDEIHTGTADSVTFEQKLPDGEMKLTSITEYYLQRYNYRLKFPHLPLVTSKRAKCYDFYPMELMSILPGQRIKQSHMTVDIQSYMTGKMSSLPDQHIKQSKLVLTEYLKLGDQPANRQMDAFRVSLKSIQPIVTNAHWLSPPDMKFANNQLYSLNPTRGVRFQTNGKFVMPARVKSVTIINYDKEFNRNVDMFAEGLAKHCSEQGMKFDSRPNSWKKVNLGSSDRRGTKVEIEEAIRNGVTIVFGIIAEKRPDMHDILKYFEEKLGQQTIQISSETADKFMRDHGGKQTIDNVIRKLNPKCGGTNFLIDVPESVGHRVVCNNSAEMRAKLYAKTQFIGFEMSHTGARTRFDIQKVMFDGDPTVVGVAYSLKHSAQLGGFSYFQESRLHKLTNLQEKMQICLNAYEQSSSYLPETVVVYRVGSGEGDYPQIVNEVNEMKLAARKKKHGYNPKFLVICTQRNSHIRVFPEHINERGKSMEQNVKSGTCVDVPGASHGYEEFILCCQTPLIGTVKPTKYTIIVNDCRWSKNEIMNVTYHLAFAHQVSYAPPAIPNVSYAAQNLAKRGHNNYKTHTKLVDMNDYSYRIKEKHEEIISSEEVDDILMRDFIETVSNDLNAMTINGRNFWA
Protein: DUF1995 domain protein, putative (DUF1995) (Q94K68)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAYSSVPSCFHGYLLHRCSFSTTQFFSGSLSCGFSASTNSRLRTCVKFEKFQGDSPLEQNTSVSSSSSVSQELPLEEAQDQLEEEEDDDDCLPNDLEGAVRQSGEAGAAFVNSGGNRAIVELLIPQLQFLDDEGAQAELWDLSRVFLETLIKETGCERVKAVFPDAGAAALLKYRWKDATFGFASLSDRKPVEKEDEIIVMVVPDYQMLEYVEKIANGLADDPPRPLIMWNPRLISEEVGVGFNVRKLRRYFLSSFTTVYSMRPLAAGAVFRCYPGKWKVFYDNKDRPGRYLLAKELIGRPDAEDLEIIYGGVEEKSEEGPSLMSQAAGIFSSINRFMKSM
Protein: Chitinase (O17423)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
WANYRPGDGKFTPSDIDPSLCTHISYTFFGISDAGEFKSLDTWLDMDDGLGFISQTIALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAFIQQYGFDGLDIDW
Protein: Rap1 GTPase-GDP dissociation stimulator 1 (E9Q912)
Organism: Mus musculus (Mouse)
Function: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52306}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P52306}. Mitochondrion {ECO:0000250|UniProtKB:P52306}. Nucleus {ECO:0000250|UniProtKB:P52306}. Note=Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region. {ECO:0000250|UniProtKB:P52306}.
Interaction partners:
Sequence:
MDNLSDTLKKLKITAADRTEGSLEGCLDCLLQALAQNNAETSEKIQGSGILQLFANLLTPQASCTAKVADIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCGRTDPASEKLMTVFCGMLMNYSNENDSLQAQLISMGVIPTLVKLLGIHCHNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSNKEDDVAELKTASDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDGNCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVVNKAKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNAKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGPAEKDLASAQLVQILHRLLADERSAPEIKYNSMVLICALMGSESLYKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLTVES
Protein: Ras guanine nucleotide exchange factor E (RasGEF domain-containing protein E) (Q8IS18)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.
Interaction partners:
- Ras-like protein rasD
Sequence:
MDHTECNNRIEYLQNKVLELESLNENLKGQLEYFQTKFLESNLNSEGKDISSCLTEIYNSLSLDNNNNNSNSNSNSNNNSSNSNNNSYSNFNSNNNTTNNTKVIKNRNFKINLTNSNSTNSSPYIFGNNKDNSNNSNNSNNNNSNTELSNDHLSLEDNIATTNTTTTTTINTSNSNNSNNNNNNNNNNNNNNNNNNNNNNKPTSNRPPVAPRSFIRSNSDTFITPPGSPTSSRNSPTNKSSPQFLSPLSKSPLSQSTQSTTVSSPSPSWTTTVPQSKMRSETIVQSKSPYSPDTNISNKLINELASNIGAPNSNGSESPSKNSPRSLNSNNNNSSATTSITTPPTTSTPTPTTSTTTTTTTERRPEDRRSKTSPFPNVGTTTPPLSNSAHLVRTQSASGANAVKPQSQLSTSCTVNMIGGGGTPRSNNSSNGSLYHSMSSNGLIENLSTSSSLSLSSTSPSPNNSQQNLTNPFEIGADDELEVLDDPRLVMVKTENGFIVKGGTIEKLVNRLIAKHDPDFTSAFLLTHKSFTTSIELLDLLIEFYVNNKDSSSINSNSSSSSSSAVASSSFSNINCNISDLSSSTSSTNSLLINSITNSPIINSNNQNNQNNNNNNNNNNNNNNNQLEINGDKKKKAIRLKITNVIKSWVDKHYYDFSEDKQLTLKLDQFITNHIMFDMDKIGFNLKRLLTNDRVVPVPTFTQGPPTPIPPKMKSNGSEINFKDLDPTEIARQLTLYESDLFRKIGAKECLGQAWNKDGKEENAPNIVSFIKRFNQVSSWVATEIVRQEKLKDRVSYIKRFILVAQECRKLNNFNATMEILSGLQNSSVYRLRKTWERVESKPLLKNTLDELMSLMSSGANYKNYIQELHNIHPPCIPYLGVYLTHLTFIEDGMKNVLTTTTATTTNTTTTTTTTTTTTTTNTTTSNNNNQQQLNGANRSFDDVIINFEKCRKISVVIREIKQYQQQQYHLHTEEFTLRYLSNLPSIQTQKSMYKLSLICEPKEKETSSFDSGYGSVSDRPSKKEFSVTSLLNSFKS
Protein: Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) (P00884)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05062}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:P05062}.
Interaction partners:
- ATP-dependent 6-phosphofructokinase, liver type
- Fructose-1,6-bisphosphatase 1
- ATP-dependent 6-phosphofructokinase, platelet type
- ATP-dependent 6-phosphofructokinase, muscle type
- Ketohexokinase
- Triosephosphate isomerase
- Triosephosphate isomerase.
- Triokinase/FMN cyclase)
- Triosephosphate isomerase
- Fructose-1,6-bisphosphatase isozyme 2
Sequence:
MAHRFPALTSEQKKELSEIAQRIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFRELLFSVDNSISQSIGGVILFHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRISDQCPSSLAIQENANALARYASICQQNGLVPIVEPEVLPDGDHDLEHCQYVSEKVLAAVYKALNDHHVYLEGTLLKPNMLTAGHACTKKYTPEQVAMATVTALHRTVPAAVPSICFLSGGMSEEDATLNLNAIYRCPLPRPWKLSFSYGRALQASALAAWGGKAANKKATQEAFMKRAVANCQAAQGQYVHTGSSGAASTQSLFTASYTY
Protein: Myocardin related transcription factor A (A0A494BZX7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDFSSVVCLPPSVIAVNGLDGGGAGENDDEPVLVSLSAAPSPQSEAVANELQELSLQPELTLGLHPGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGGNPRNFSRFQGAAIPAREGEAIPEDSLWVPPGSTAITFC
Protein: Probable gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (GSA dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (Q9UT44)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity).
Interaction partners:
- Probable glutamate 5-kinase
- Probable delta-1-pyrroline-5-carboxylate dehydrogenase
- Glutamate synthase
- Glutamine synthetase
- Probable NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
- ATP synthase subunit alpha
- Uncharacterized GTP-binding protein P8A3.11c
- Imidazole glycerol phosphate synthase hisHF
- ATP phosphoribosyltransferase
Sequence:
MSLEENVKEAKNAFNILQTLSVEDRDDALDKIVEELRIKKSEVLAANAEDMKAAKLLAESGKLSSSMVKRLDLSSSDKYDSMVQGVLDVKSLPDPLGRVTYARSLDDGLDLYKVSCPVGLLLVIFEARPEVIINITSLAIKSGNAVVLKGGTESAKSFAALSNVVRSALGKSKVPQAAVQLVQSREEVSQLLKLDEYIDLVIPRGSTNLVRHIKDNTKIPVLGHAAGLCSMYVHEDADMELASKLVLDGKTDYPAACNAIETLLINEAVLSSHLPKIAETLTEAKVTLKCDPASLKVLKDMPKVSALVEPSVDQDYNTEFSDLILAIKTVPSLQSAMQHINTHGSKHTDCIITSSEAAANRFMAGIDASGVYWNASTRFADGFRYGYGTEVGISTNKIHARGPMGLDGLTIYKYQLRGNGQVASSYGVGPGKRAFKHTPINIDNISQVSKK
Protein: 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA (EC 2.1.1.226) (EC 2.1.1.227) (16S rRNA (cytidine1409-2'-O)-methyltransferase) (23S rRNA (cytidine1920-2'-O)-methyltransferase) (Hemolysin TlyA) (P9WJ63)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20854656}. Secreted, cell wall {ECO:0000269|PubMed:26347855}. Host cell membrane {ECO:0000269|PubMed:20854656}. Note=Can bind to target membranes such as macrophage phagosomal membranes (PubMed:20854656). In native and recombinant hosts (M.smegmatis and E.coli), M.tuberculosis TlyA can reach the bacterial surface in functional form and colocalizes with the HBHA protein which is known to be part of cell-wall (PubMed:26347855). TlyA does not seem to depend on either Tat or Sec pathways for translocation to cell-wall (PubMed:26347855). Appears to be capable of reaching the extra-cellular milieu using a vesicle mediated transport (PubMed:26347855). {ECO:0000269|PubMed:20854656, ECO:0000269|PubMed:26347855}.
Interaction partners:
- NAD kinase
- N-acetyltransferase Eis
- DNA gyrase subunit A
- Tetratrico peptide repeat group 5 domain-containing protein
- Uncharacterized protein
- D-glycerol 3-phosphate phosphatase
- Ribosomal RNA small subunit methyltransferase G
- DNA repair protein RecN
- DNA gyrase subunit B
- Probable transcriptional regulator WhiB7
Sequence:
MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSERAWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP
Protein: Bacteriocin enterocin-P (O30434)
Organism: Enterococcus faecium (Streptococcus faecium)
Function: Bacteriocin that inhibits the growth of wide range of Gram-positive bacterial species. Does not inhibit the growth of several strains of Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:9361419}.
Interaction partners:
Sequence:
MRKKLFSLALIGIFGLVVTNFGTKVDAATRSYGNGVYCNNSKCWVNWGEAKENIAGIVISGWASGLAGMGH
Protein: Probable metallo-hydrolase Rv2300c (EC 3.-.-.-) (P9WLD7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
Sequence:
MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPPVKVHHLNCGTMNAFGIALLCHVLLVETDDGLVLVDTGFGIQDCLDPGRVGLFRHVLRPAFLQAETAARQIEQLGYRTSDVRHIVLTHFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGPKLVEHGPDGEPWRGFASAKPLDSIGTGVVLVPMPGHTRGHAAVAVDAGHRWVLHCGDAFYHRGTLDGRFRVPFVMRAEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA
Protein: Transcription factor HEC3 (Basic helix-loop-helix protein 43) (AtbHLH43) (bHLH 43) (Protein HECATE 3) (Transcription factor EN 119) (bHLH transcription factor bHLH043) (Q9LXD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the female reproductive tract development and fertility.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Agamous-like MADS-box protein AGL11
- SNF1-related protein kinase catalytic subunit alpha KIN12
Sequence:
MNNYNMNPSLFQNYTWNNIINSSNNNNKNDDHHHQHNNDPIGMAMDQYTQLHIFNPFSSSHFPPLSSSLTTTTLLSGDQEDDEDEEEPLEELGAMKEMMYKIAAMQSVDIDPATVKKPKRRNVRISDDPQSVAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLNNNTGYTPPPPQDQASQAVTTSWVSPPPPPSFGRGGRGVGELI
Protein: Sal-like protein 3 (MSal) (Spalt-like protein 3) (Q62255)
Organism: Mus musculus (Mouse)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSRRKQAKPQHLKSDEELPPQDGASEHGVPGDGAEDADSGSESRSGSEETSVCEKCCAEFFKWADFLQHKKTCTKNPLVLIVHDDEPAPPSEDFPEPSPASSPSDRTESEVAEEVAPTEGSEVKAATKEAEPMDVEVSTDKGPPGPSVPPPPPALPPQPEPAAFSMPSTNVTLETLLSTKVAVAQFSQGARAGGTTGAGGSVGAVAIPMILEQLVALQQQQIHQLQLIEQIRSQVALMSRQPGPPLKPSASAPGTASVQLQGLTPHAALQLSAGPATASAGSGSTLPAAFDGPQHLSQPASGTSTPCSTSAAPPDSGAHPACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSSASNLPNPLLPQTSSSSVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGLQLPPTVPGTHNYTDSPSITPVSRSPQRPSPASSECTSLSPGLNNTESGITVRPESPQPLLGGPSLTKAEPVSLPCTSTRTGDAPVVGGQVSGLPTSAATAVTDSACTSLGSPGLPAVSDQFKAQFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAMDADLPFDEKNAETLSSFDDDIDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIDSVMNCQQLANLKSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDSPPPGPGNGGALDLTAGHPGRPLIKEEAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRSHTKERRFVCTVCRRGCSTMGNLKQHLLTHKLKELPSQVFDPNFTLGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGVQVPTGPQTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGGGAIPPLGAMASGVDKARTGSSPPIVSLDKASSETGASRPFARFIEDNKEIGIN
Protein: Ras-related protein Ral-A (EC 3.6.5.2) (P63322)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (By similarity). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11233}; Lipid-anchor {ECO:0000250|UniProtKB:P11233}; Cytoplasmic side {ECO:0000250|UniProtKB:P11233}. Cleavage furrow {ECO:0000250|UniProtKB:P11233}. Midbody, Midbody ring {ECO:0000250|UniProtKB:P11233}. Mitochondrion {ECO:0000250|UniProtKB:P11233}. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles. May colocalize with CNTRL/centriolin at the midbody ring. However, localization at the midbody at late cytokinesis was not confirmed. Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission. {ECO:0000250|UniProtKB:P11233}.
Interaction partners:
- RalA-binding protein 1
- Exocyst complex component 2
- Ral guanine nucleotide dissociation stimulator
- Exocyst complex component 8
- Exocyst complex component 4
- Phospholipase D2
- Phospholipase D1
- Ral guanine nucleotide dissociation stimulator-like 2
- Ral guanine nucleotide dissociation stimulator like 1
- Exocyst complex component 5
Sequence:
MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRADQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL
Protein: Transcription factor HHO1 (MYB-domain transcription factor HHO1) (Protein HRS1 HOMOLOG 1) (Q9LS00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable factor involved in nitrate and phosphate signaling in roots. Integrates nitrate and phosphate starvation responses and adaptation of root architecture, depending on nutrient availabilities. Acts downstream of the nitrate sensor and transporter NPF6.3/NRT1.1. Represses primary root development in response to phosphate deficiency conditions, only when nitrate is present.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:25723764}.
Interaction partners:
- LOB domain-containing protein 37
- LOB domain-containing protein 39
- Protein NLP7
- High-affinity nitrate transporter 2.1
- Expressed protein
- Polynucleotide 5'-hydroxyl-kinase NOL9
- Filaggrin-like protein
- Protein NRT1/ PTR FAMILY 6.3
- High affinity nitrate transporter 2.4
- MADS-box transcription factor ANR1
Sequence:
MIKNLSNMKNDNQKREKCCEYIEALEEERRKINVFQRELPLCVELVTQAIEAYKREISGTSTDNLYGQSECSEQTTGECGRILDLFIPIKHSSTSIEEEVDDKDDDDEEHQSHETDIDFDDKNMKSEWLKSVQLWNQSDAVVSNNRQDRSQEKTETLVELIKINDEAAKKNNNIKSPVTTSDGGSGGGGGRRGQRKNRRCWSQELHRRFLNALKQLGGPHVATPKQIRDIMKVDGLTNDEVKSHLQKYRLHARRPSQTTPNNRNSQTQHFVVVGGIWVPQTNHSTANAVNAVASGETTGIYGPMVSSLPSEWPRHSNFGRKISEDRSRCSNNGFFRCSSPAMSCSTRTKTKDAKIIS
Protein: Leucine-rich repeat extensin-like protein 1 (AtLRX1) (LRR/EXTENSIN1) (Cell wall hydroxyproline-rich glycoprotein) (O65375)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. Together with LRX2, component of the extracellular mechanism regulating root hair morphogenesis and elongation.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:11331608}. Note=Specifically localized in the wall of the root hair proper.
Interaction partners:
- Proline-rich extensin-like family protein
- Proline-rich extensin-like family protein
- Proline-rich extensin-like family protein
- Proline-rich extensin-like family protein
- Proline-rich protein 3
- Extensin-2
- Expansin-A7
- Extensin-1
- Expansin-A18
- Probable pectinesterase/pectinesterase inhibitor 46
Sequence:
MLFPPLRSLFLFTLLLSSVCFLQIKADHDDESDLGSDIKVDKRLKFENPKLRQAYIALQSWKKAIFSDPFNFTANWNGSDVCSYNGIYCAPSPSYPKTRVVAGIDLNHADMAGYLASELGLLSDLALFHINSNRFCGEVPLTFNRMKLLYELDLSNNRFVGKFPKVVLSLPSLKFLDLRYNEFEGKIPSKLFDRELDAIFLNHNRFRFGIPKNMGNSPVSALVLADNNLGGCIPGSIGQMGKTLNELILSNDNLTGCLPPQIGNLKKVTVFDITSNRLQGPLPSSVGNMKSLEELHVANNAFTGVIPPSICQLSNLENFTYSSNYFSGRPPICAASLLADIVVNGTMNCITGLARQRSDKQCSSLLARPVDCSKFGCYNIFSPPPPTFKMSPEVRTLPPPIYVYSSPPPPPSSKMSPTVRAYSPPPPPSSKMSPSVRAYSPPPPPYSKMSPSVRAYPPPPPPSPSPPPPYVYSSPPPPYVYSSPPPPPYVYSSPPPPPYVYSSPPPPYVYSSPPPPYVYSSPPPPPPSPPPPCPESSPPPPVVYYAPVTQSPPPPSPVYYPPVTQSPPPPSPVYYPPVTNSPPPPSPVYYPPVTYSPPPPSPVYYPQVTPSPPPPSPLYYPPVTPSPPPPSPVYYPPVTPSPPPPSPVYYPPVTPSPPPPSPVYYPSETQSPPPPTEYYYSPSQSPPPTKACKEGHPPQATPSYEPPPEYSYSSSPPPPSPTSYFPPMPSVSYDASPPPPPSYY
Protein: p-GlycoProtein related (Q19015)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKWIKKLCRPVSAFGDESKVSDVTPSIRQSLNLMINFAKKSDLIFIITALICALLGGTIQPVVLLIGGWITDLYLTNGNTAGNDEFLYSVLTLIYAGLGFGVIILVLALIQGVCIQRGTSRILDSIRKEFLGAVLRQDANWLDKHSSGSITCQLNENIEVISDGLGNKCCMLVRGFAMFTSSIIACAFINWQLTFITFTMGPVSAFVLHLLTKVNEVSNEELMSLSAQSHAIIEESILNVRTVQSCNGQNFMITKLNQVNEKIKKFYNKSTFWAGFFDGLALFVIYFITGISLFFGCRLYFNQEIGKAGDVILIVNTICVTGYFLGLLGPHMSSLQQAATSFLLLYKTIESAPKSEGKEGEIKISSTRGNIEFRDVRFKYFTRDNEVLQGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEGEILIDGKNIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGRNVDEETIKTAADIANASSFIEKLENGYETRLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSHNEHIVNKALTKASEGRTTIIIAHRLSSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARLAKSQEVEQSSKKDWEREELRRAEKMKKKGRTVEIIEPNSTILQEHEHNFVGSVITENEEQKISFSGISKLFNYLPKHRKTLILIIALLIPRAIELCSYGIGMSFAFKTLQRSKDDYMTWNYITLAQQTLAGITFWILHTSLMYLCGWLANEVMNEVKQEMLSEVLNKPIPYFDNPETSPSACVSRIISHAHNCYACLDHRAIRFVWFIAGTIFSLLLAFPFVWELGVLGLGITILLTIFSLHFVSVAHRAHSEKSVMDKSGEFAVEIVEHIRAIKLLAVEGYFENKFSEYLKTSEIYENKIGFVSSLNFAITQSYVFACDMLLFFVGTLLIYHGRYSPDKVFLAFNGAQMSAWGVMYFSPWFPEIVRGSASANQIFSFFDKNRTNSTSGLSKPEINGKVEVSDVTFAYPSTPHRNVCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGIDVNHLRNNISVVGQEPVLFNATIRENITIGIDEVSVEEVQKACKAANAAGFIESFPLGYDTIVGEGGASLSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLSTVQHCDTIYYISRGAVAEYGTHAELVAMDSKYARLVAAQSLS
Protein: Mutant heparan N-sulfatase (Q9EQ07)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHCPGLACCTILLVLGLCGAHSRNVLLIVANDGGFESGVYNNTAIATPHLDALSRHSLIFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVQSLPLLLNQAGVRTGIIGKKHVGPETVYPFDFAFTEENSSVMQVGRNITRIKQLVQKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGYIPDWTPQIYDPQDVMVPYFVPDTPAARADLAAQYTTIGRMDQGVGLVLQELRGAGVLNDTLIIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPQRWGQVSDAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIQLTGRSLLPALEAEPLWATVFSSQSHHEVTMSYPMRSVYHQNFRLIHNLSFKMPFPIDQDFYVSPTFQDLLNRTTTGRPTGWYKDLHRYYYRERWELYDISRDPRETRNLAADPDLAQVLEMLKAQLVKWQWETHDPWVCAPDGVLEEKLTPQCRPLHNEL
Protein: Synaptosomal-associated protein 47 (Synaptosomal-associated 47 kDa protein) (Q55GN5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTSPADKANHLKVKTELVRRTFNYPETENVIQDYSCALNKVTLGKMYITENFLSFIASIGSTTETIPLRKILEMKKDTTLFVNNAITFKTAEQLVSFGTFSHRDEAFTLIYHLWKCPPFIYNPNSVDKDLDEKNLFRGAGQQKQKQLSSRVDTQSTKLALKLATETKETGIATLNELSYQAEVIDGIEAKMDNIHANLDRSDRLLKGIESVGGALSNHFSKDTTNGPRKEFAPLDRSLQVRPRDEPPIEIDILEKLANDSLIPGFVQIHNDRFIILDANRKPRTEIISTYTFDSVEYLVIRARPQHMDVRFFNNKYPRFRMASSYIQNVVNEIVLRSNGKYGKAPQVIFEPGIKEFIYGNPTIRFIPSSGRSQQSSLFTRASTLGTSHFIKDASDDIKDALIEQDKDLDEISDLLGDISNIAKTIGDEAERSSSQLDRITDKVDHANDRLKNNNKRIQKML