wanglab/gogpt-training-data huggingface dataset:
Protein: Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) (Q60829)
Organism: Mus musculus (Mouse)
Function: Inhibitor of protein-phosphatase 1.
Subcellular location: Cytoplasm.
Interaction partners:
- Cyclin-dependent kinase 5
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- D
Sequence:
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRVSEHSSPEEEASPHQRTSGEGHHPKSKRPNPCAYTPPSLKAVQHLQTISNLSENQASEEEDELGELRELGYPQEDDEEDEDEEEDEEEDSQAEVLKGSRGTVGQKPTCGRGLEGPWERPPPLDEPQRDGNSEDQVEGRATLSEPGEEPQHPSPP
Protein: 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) (Q99L13)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Aldehyde dehydrogenase, mitochondrial
- 4-trimethylaminobutyraldehyde dehydrogenase
- Alpha-aminoadipic semialdehyde dehydrogenase
- Peroxisomal bifunctional enzyme
- Aldehyde dehydrogenase X, mitochondrial
- Aldehyde dehydrogenase family 3 member A2
- Propionyl-CoA carboxylase alpha chain, mitochondrial
Sequence:
MAASLGFRGAASGLWYWSGRRRPVGSLAAVCSRSMASKTPVGFIGLGNMGNPMAKNLMKHGYPLILYDVFPDVCKEFKEAGEQVASSPAEVAEKADRIITMLPSSMNAVEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLECMGSNVVYCGAVGTGQSAKICNNMLLAISMIGTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMHGVPSSNNYQGGFGTTLMAKDLGLAQDSATSTKTPILLGSLAHQIYRMMCSKGYSKKDFSSVFQYLREEEPF
Protein: Homeobox protein Hox-B13 (Q92826)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
Subcellular location: Nucleus.
Interaction partners:
- Small nuclear protein PRAC1
- Homeobox protein Meis1
- Homeobox protein Meis2
- Protein PRAC2
- Paired mesoderm homeobox protein 2
- Androgen receptor
- Transcriptional enhancer factor TEF-3
- Interleukin-17 receptor B
Sequence:
MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEYPSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP
Protein: Survival motor neuron Tudor domain-containing protein (Q381T5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVRRNNKSTESTIVFTRGAGDNSLWDDADLIRLWNAQLEEDQCEKAEDEAPVPSTVSEDGSLITTEDDEVAESEQKSSLRSFQSGQREAGVASAIVTAAPINASVAPVVLHQSMFDRLPADIRQLLVAYFNAGYEAGYFVGKRDGSSKVGGKRARGE
Protein: SP2353, isoform A (SP2353, isoform B) (A1ZA87)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Uncharacterized protein, isoform C
- Protein O-mannosyl-transferase Tmtc1
- Tyrosine-protein kinase transmembrane receptor Ror2
Sequence:
MSTSKHHHHHCRVVCVWLLLVLSSLSSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYEIHDGMYECDCIEGYELNKNGYSCQVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPAGNENGEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAICLCPIGFVGDLCEIRMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGEMKLNFDPNTLGTEHNVETGLL
Protein: KLRF1 protein (Killer cell lectin like receptor F1) (Q4KN05)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYKILLGISGTVNGILTLTLISLILLVSQGVLLKCQKGSCSNATQYEDTGDLKVNNGTRRNISNKDLCASRSADQTVPRPHFRLLYRKT
Protein: Os05g0139300 protein (Q6AT88)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MAMELERATKKRRGGIDDLPDDLIVDILSRLPAKSVCRFKCVSWRWRRLISHRDHRKKLPHTLSGFISRYYGPLNDDELVSIPHFDSIDGGEEDEEEHRLVPDPSLSFLLGYMSISPKDCCNGLLLCLCCKNSPRDESDYVVCNPATQRWIILPEIDDYDQLASIRLCFDPALSPYFHVFAILEDADGCITGVEIFSSETGGGATGRMVGLTKMITCRQWSFKYNISTSQLFGWTNMRLERKYNLIAIHPDCNMIFYVSRDEGQNTLLSYDMDRGEINSICNIRDPFWNPWDPCLPYVPVFMESLPDHA
Protein: Ferric reductase transmembrane component 3 (EC 1.16.1.9) (Ferric-chelate reductase 3) (Q08905)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11120744}; Multi-pass membrane protein {ECO:0000269|PubMed:11120744}.
Interaction partners:
- Probable ferric reductase transmembrane component 8
- Iron-regulated transcriptional activator AFT1
- Iron transport multicopper oxidase FET3
- Facilitator of iron transport 2
- Siderophore iron transporter ARN1
- Facilitator of iron transport 3
Sequence:
MYWVLLCGSILLCCLSGASASPAKTKMYGKLPLVLTDACMGVLGEVTWEYSSDDLYSSPACTYEPALQSMLYCIYESLNEKGYSNRTFEKTFAAIKEDCAYYTDNLQNMTNADFYNMLNNGTTYIIQYSEGSANLTYPIEMDAQVRENYYYSYHGFYANYDIGHTYGGIICAYFVGVMILASILHYLSYTPFKTALFKQRLVRYVRRYLTIPTIWGKHASSFSYLKIFTGFLPTRSEGVIILGYLVLHTVFLAYGYQYDPYNLIFDSRREQIARYVADRSGVLAFAHFPLIALFAGRNNFLEFISGVKYTSFIMFHKWLGRMMFLDAVIHGAAYTSYSVFYKDWAASKEETYWQFGVAALCIVGVMVFFSLAMFRKFFYEAFLFLHIVLGALFFYTCWEHVVELSGIEWIYAAIAIWTIDRLIRIVRVSYFGFPKASLQLVGDDIIRVTVKRPVRLWKAKPGQYVFVSFLHHLYFWQSHPFTVLDSIIKDGELTIILKEKKGVTKLVKKYVCCNGGKASMRLAIEGPYGSSSPVNNYDNVLLLTGGTGLPGPIAHAIKLGKTSAATGKQFIKLVIAVRGFNVLEAYKPELMCLEDLNVQLHIYNTMEVPALTPNDSLEISQQDEKADGKGVVMATTLEQSPNPVEFDGTVFHHGRPNVEKLLHEVGDLNGSLAVVCCGPPVFVDEVRDQTANLVLEKPAKAIEYFEEYQSW
Protein: Organic cation transporter-like protein (Q95R48)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably transports organic cations.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGETNGSTIANGHK
Protein: Toxin coregulated pilus biosynthesis protein P (TCP pilus biosynthesis protein TcpP) (P29485)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Involved in TCP pilus biogenesis.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Toxin coregulated pilus biosynthesis protein H
- Transmembrane regulatory protein ToxS
Sequence:
MGYVRVIYQFPDNLWWNECTNQVYYAQDPMKPERLIGTPSIIQTKLLKILCEYHPAPCPNDQIIKALWPHGFISSESLTQAIKRTRDFLNDEHKTLIENVKLQGYRINIIQVIVSENVVDEADCSQKKSVKERIKIEWGKINVVPYLVFSALYVALLPVIWWSYGQWYQHELAGITHDLRDLARLPGITIQKLSEQKLTFAIDQHQCSVNYEQKTLECTKN
Protein: Transcription factor TCP2 (Protein TEOSINTE BRANCHED 1) (Protein TEOSINTE-LIKE1, CYCLOIDEA, and PROLIFERATING CELL FACTOR 2) (Q93V43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule develpment. Participates in ovule develpment. Promotes light-regulated transcription of CHS, CAB, HYH and HY5. Regulates positively photomorphogenesis (e.g. hypocotyl elongation inhibition and cotyledon opening in response to blue light).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger AN1 and C2H2 domain-containing stress-associated protein 11
- Transcription factor TCP15
- Transcription factor TCP14
- Transcription factor TCP20
- Transcription factor TCP21
- Transcription factor TCP8
- Transcription factor TCP23
- Transcription factor TCP19
- Transcription factor TCP16
- Transcription factor TCP7
Sequence:
MIGDLMKNNNNGDVVDNEVNNRLSRWHHNSSRIIRVSRASGGKDRHSKVLTSKGPRDRRVRLSVSTALQFYDLQDRLGYDQPSKAVEWLIKAAEDSISELPSLNNTHFPTDDENHQNQTLTTVAANSLSKSACSSNSDTSKNSSGLSLSRSELRDKARERARERTAKETKERDHNHTSFTDLLNSGSDPVNSNRQWMASAPSSSPMEYFSSGLILGSGQQTHFPISTNSHPFSSISDHHHHHPHHQHQEFSFVPDHLISPAESNGGAFNLDFNMSTPSGAGAAVSAASGGGFSGFNRGTLQSNSTNQHQSFLANLQRFPTSESGGGPQFLFGALPAENHHHNHQFQLYYENGCRNSSEHKGKGKN
Protein: GTP-binding protein EsdC (G5EB84)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D1
- U1 small nuclear ribonucleoprotein C
- PHF5-like protein
- 116 kDa U5 small nuclear ribonucleoprotein component
- U2 small nuclear ribonucleoprotein A'
- Increased recombination centers protein 6
- Small nuclear ribonucleoprotein Sm D3
Sequence:
MSAVQLKFNLRTSSNVKTVHLLGSWDNYSRQIPLSRDSSKPGSWVGKFRFQTSMLKLGGRYWYYYILDGYHVSHDPAADYTVEPTTNRKLNILDVPGGKESSSSARRPRRGSSDIATGRALSPSKIHHPKPSKPYASRQIREADFAPTHAMDELSRRFGSSRLSDDGYSDLSNSPPSSVGSSLSSRSSGSTSPSSLSSMSDPPSVCHCERYGITRKGDRVKLDCGGSRCGYLSETSGDSCSEDSDSDEEYRRARRGVRRQGIVVRR
Protein: Tethering factor for nuclear proteasome STS1 (Dumbbell former protein 8) (SEC23 suppressor 1) (P38637)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. Required for efficient chromosome segregation. Restores protein transport and ribosomal RNA stability.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase RPN11
- Importin subunit alpha
- Proliferating cell nuclear antigen
- PAN2-PAN3 deadenylation complex subunit PAN3
Sequence:
MMGFEWGFKPSSKITQSTVSSQGTGNVMIPTAGVKQKRRYANEEQEEEELPRNKNVMKYGGVSKRRPQPGSLIRGQPLPLQRGMELMNKNQLQQLLVDLMTKHPEIQQSVHTRVIGLDFSIQKCLDMLKQKSEAVYQSIPYNRSYESNKLDDYAFVRMKPQILEFLNCLVDFILDNIPPRLENLHASLKFLDICTELVIKLPRFELASNNYYYDKCIEQLSHVWCTLIEHVARDRIILLADNSSVWKSHMTRLQVYNEHSNGLLERPLQLFKSLDMGSPSAASSSTLSLQESIIYHHDTMTANENNNNSGSAATDSPFN
Protein: Dimethyl-sulfide monooxygenase (EC 1.14.13.131) (Dimethylsulfide monooxygenase large subunit) (E9JFX9)
Organism: Hyphomicrobium sulfonivorans
Function: Monooxygenase that mediates oxidation of dimethyl sulfide, the first step in dimethyl sulfide degradation pathway. Has much lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides.
Interaction partners:
- Acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase
- FMN reductase
- FMN reductase
Sequence:
MKKRIVLNAFDMTCVSHQSAGTWRHPSSQAARYNDLEYWTNMAMELERGCFDCLFIADVVGVYDVYRGSAEMALRDADQVPVNDPFGAISAMAAVTEHVGFGVTAAITFEQPYLLARRLSTLDHLTKGRVAWNVVSSYLNSAALNIGMDQQLAHDERYEMADEYMEVMYKLWEGSWEDDAVKRDKKSGVFTDGSKVHPINHQGKYYKVPGFHICEPSPQRTPVIFQAGASGRGSKFAASNAEGMFILTTSVEQARQITTDIRNQAEAAGRSRDSIKIFMLLTVITGDSDEAAEAKYQEYLSYANPEGMLALYGGWTGIDFAKLDPDEPLQAMENDSLRTTLESLTHGENAKKWTVRDVIRERCIGGLGPVLVGGPQKVADELERWVDEGGVDGFNLAYAVTPGSVTDFIDYIVPELRKRGRAQDSYKPGSLRRKLIGTNDGRVESTHPAAQYRDAYVGKESVADRTQPSPFANAKAPVAE
Protein: TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) (B9EKI3)
Organism: Mus musculus (Mouse)
Function: Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Note=Concentrated at the budding structures localized at the tips of cisternae. {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-6A
- Ras-related protein Rab-6B
- Vacuolar protein sorting-associated protein 54
Sequence:
MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSAWAEAIPYGEPGISPPVSGGWDTSTWGLNSTSSEPQSPPTASQAITKPVRRTVVDESENFFSAFLSPSDAHTIQKSPVVSKPPSKSQRPEEEVKSSLQESSSPGQSRVSETAEVRDSVCVSGETSAVGTPSPVPEDKHEETAGEESEVKVPTVRLKASENVVNVNTTEDVSTTSTQSLTAETKDMALEPKEQKHEDRQSNTPSPPVSSFSSGTSTTSDIEVLDHESVISESSASSRQETSDAKSSLHLMQTSFQLLSASACPEYSRLDDFQKLNESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELPGKGYALVPIIVSPSTPKTKVVESTEENAEEEEGNETLVAPSEEAELEESGRSATPVNCDQPDILASPTAGSGGHSASGPATEQCEAVENQPKAPPEKEDVCKTVEFLNEKLEKRETQLLSLSKEKALLEEAYDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEMKTIKEELATRLNSSQTADLLKEKDEQIQGLMEEGEKLSKQQLHNSNIIKKLRAKDKDNENVIAKLNRKAKELEEELQHLRQVLDGKEEVEKQHRENIKKLNSVVERQEKDLGRLQVDMDELEEKSRSTQAALDSAYRELTDLHKANAAKDSEVQEAALRREMKAKEELSGALEKAQEEARQQQEALVLQVGDLRLALQRAEQAAARKEDYLRHEISELQQRLQEAENRNQELSQSVSSTARPLLRQIENLQATLGSQTSSWETLEKSLSDRLGESQTLLAAAVERERAATEELLANKIQMSSVESQNTLLRQENSRLQAQLESEKNKLRKLEDENSRYQVELENLKDEYVRTLEESRKEKTLLSSQLEMERMKVEQERKKTIFTQEALKEKDHKLFSVCSTPTMSRSSSISGVDAAGLQASFLSQDESHDHSFGPMSTSASGSNLYEAVRMGAGSSIIENLQSQLKLREGEISHLQLEISNLEKTRSIMSEELVKLTNQNDELEEKVKEIPKLRVQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQRLS
Protein: Versiconal hemiacetal acetate esterase stcI (EC 3.1.1.94) (Sterigmatocystin biosynthesis cluster protein I) (Q00675)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Esterase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins. The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK. The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF. 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG. The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme. The cytochrome P450 monoxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone. The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone. The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin. The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin. The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP.
Interaction partners:
- Versicolorin B synthase stcN
- Alpha/beta hydrolase fold-3 domain-containing protein
- FAD-binding monooxygenase stcW
Sequence:
MQGWKTIVGKLMSRYDFPLPDLSVQAEDKILGGVPTRIYTPPDVADPPLALYFHAGGWVMGSIDEEDGFVRTLCKLARTRIFSVGYRLAPEFRFPMALDDCLTVARSVLETYPVQSICFIGASAGGNMAFSTALTLVSDGLGDRVQGVVALAPVTVHPDSVSADNRDRGEYTSYEENDRLTINTGSAMRSFFDCYGAPPDDPRLSCLLHPGLGKLNKVYMAVGDADTLRDDVRLMRDALVALEVPVKCDEYPGYPHFSWLFPSPALREHQALFFGNLLSGICWVCE
Protein: Mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39) (Q7SXW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (By similarity). Involved in the early steps of heme biosynthesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Transmembrane protein 14C
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
- Solute carrier family 22 member 4.
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- ATP-binding cassette sub-family B member 6
- ATP-binding cassette sub-family B member 10, mitochondrial
- 5-aminolevulinate synthase.
- Ferrochelatase
- Glutaredoxin-related protein 5, mitochondrial
Sequence:
MGDRPAVRISAAITPVQQMLASGTGAVLTSLFVTPLDVVKIRLQAQQTPLFQAIAAESRPWFRVTRPSKWKCFLYCNGLMDHVYVCQNMSSCSNLYKTSTHFSGTLDAFVKITHNEGLRSLWSGLPPTLVMAVPATVIYFTCYDQLRDFLCYSMGYHGDHIPLIAGGLARLGAVSVISPLELVRTKMQSRRLQYSELMVCIRSSVAQDGWLSLWRGWGPTVLRDVPFSALYWFNYELVKAQLCEHYRTPQASFTISFTAGAVSGAIAAVLTLPFDVVKTRRQIQLGEMEALGAVSMKKPSSTWNMMRNIWIDMGYKGLFAGFLPRVIKVAPACAVMISTYEFGKTFFQERNLHQARCGL
Protein: Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) (P02547)
Organism: Sus scrofa (Pig)
Function: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Subcellular location: Cell projection, axon {ECO:0000250|UniProtKB:P08551}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08551}.
Interaction partners:
- Neurofilament medium polypeptide
- Alpha-internexin
- Neurofilament heavy polypeptide
- Microtubule-associated protein
Sequence:
MSSFYSEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAQLLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSLTTGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEGKEKEEAEAEAEAEEEGAQEEEEAAEKEESEEAKEEEGGEGEQGEETKEAEEEEKKDEGAGEEQATKKKD
Protein: Periostin (Periostin, osteoblast specific factor b isoform 2 precursor) (Periostin, osteoblast-specific factor b) (Q75U66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Lumican.
- Collagen, type I, alpha 1a.
- Transcription factor 21
- Neuregulin 1
- Collagen alpha-2
- Decorin
- NADH-ubiquinone oxidoreductase chain 4
Sequence:
MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEDFGEDSEGITTFIQEGTRRVPPRRVQGGVRRRT
Protein: High-affinity glucose transporter ght1 (Hexose transporter 1) (Q9P3U6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: High-affinity glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- SNF1-like protein kinase ssp2
- Zinc finger protein rsv1
Sequence:
MSKTLTITMLLFVSMAGWMFGADTGSIGGITNMRDFQSRFADRYNPVTDTYSYSSARQGLITGMVNVGSFFGCLISSPTTDRIGKRNSIIGFCVIYLIGVIIQVTAVPSWVQIMVAKIWTGLGIGALSVLAPGYQSEVAPPHIRGTIVVTYQLCVTAGIFIAACINMGTHKLYKTAQWRVSIGINLLWGIITLVGVSFLSESPRYLVSIGKDDEAIQVMCKNAELPPDSDIIQTEYKQIKSDCEAAVEGGPCTWPEIFGKEIRYRTFLGMAIMSFNQLTGCNYYFYYGTQVFKGTGMESPYLASLILDAVNFGCTFGGLFVLEYCGRRVPLIIGGVWQSICFFIYAAVGNRALTRKNGTSNHRAGAVMIVFSCLFIFSFAQTWGPAAYVIVGESYPIRYRSKCAAVATTSNWLWNFLISFFTPFITNSIGFKYGYIFASCNLCASIVTFLFAHESKGLTLEEINELYLSDAKPWMSRPKNLSEMAEAKEVEREETRPKGESARYLEHADSNSDSEDLSSSANNDVHEPVARQDPFNENEVEKSRTRPSQESYTTSSN
Protein: Probable xyloglucan endotransglucosylase/hydrolase protein 23 (At-XTH23) (XTH-23) (EC 2.4.1.207) (Q38910)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Expansin-like A1
- Putative expansin-A17
- Polygalacturonase ADPG2
- Expansin-B1
- Expansin-B3
Sequence:
MAMISYSTIVVALLASFMICSVSANFQRDVEITWGDGRGQITNNGDLLTLSLDKASGSGFQSKNEYLFGKIDMQIKLVAGNSAGTVTAYYLKSPGSTWDEIDFEFLGNLSGDPYTLHTNVFTQGKGDREQQFKLWFDPTSDFHTYSILWNPQRIIFSVDGTPIREFKNMESQGTLFPKNQPMRMYSSLWNAEEWATRGGLVKTDWSKAPFTASYRGFNEEACVVINGQSSCPNVSGQGSTGSWLSQELDSTGQEQMRWVQNNYMIYNYCTDAKRFPQGLPRECLAA