Protein: Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) (P97499)
Organism: Mus musculus (Mouse)
Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle.
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere.
Interaction partners:
- Telomerase reverse transcriptase
- Protein mono-ADP-ribosyltransferase PARP4
- Major vault protein
- H/ACA ribonucleoprotein complex subunit DKC1
- Transcriptional adapter 1
- Transcriptional adapter 3
- Telomerase Cajal body protein 1
- Transformation/transcription domain-associated protein
- SPT3, SAGA and STAGA complex component
- Transcription initiation factor TFIID subunit 12
Sequence:
MEKLCGHVPGHSDILSLKNRCLTMLPDLQPLEKIHGHRSVHSDILSLENQCLTMLSDLQPTERIDGHISVHPDILSLENRCLTMLPDLQPLEKLCGHMSSHPDVLSLENQCLATLPTVKSTALTSPLLQGLHISHTAQADLHSLKTSNCLLPELPTKKTPCFSEELDLPPGPRALKSMSATAQVQEVALGQWCVSKEKEFQEEESTEVPMPLYSLSLEEEEVEAPVLKLTSGDSGFHPETTDQVLQEKKMALLTLLCSALASNVNVKDASDLTRASILEVCSALASLEPEFILKASLYARQQLNLRDIANTVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDEKKLVSLPACLRAAMTDKFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKTERPFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLVEYLHIHKPAQHVQALLGYRYPATLELFSRSHLPGPWESSRAGQRMKLRRPETWERELSLRGNKASVWEELIDNGKLPFMAMLRNLCNLLRTGISARHHELVLQRLQHEKSVVHSRQFPFRFLNAHDSIDKLEAQLRSKASPFPSNTTLMKRIMIRNSKKNRRPASRKHLCTLTRRQLRAAMTIPVMYEQLKREKLRLHKARQWNCDVELLERYRQALETAVNLSVKHNLSPMPGRTLLVYLTDANADRLCPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGNDEWPLDTFGKYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHVNSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARVFPHRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYIPPSYDLPDHPHFHWTHEYPSGRSVTEMEVMQFLNRGQRSQPSAQALIYFRDPDFLSSVPDAWKPDFISESEEAAHRVSELKRYLHEQKEVTCRSYSCEWGGVAAGRPYTGGLEEFGQLVLQDVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLLQDTVQQLLLPHGRLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLALNLLRRLCTHLRQKLGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQTLVLIIDGADKLVDRNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETLQQSQGAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHSGNPFPLCPFAYLVQSLRSLLGEGPVERPGARLCLSDGPLRTTIKRRYGKRLGLEKTAHVLIAAHLWKTCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAEFLTNLHVVAAYLEVGLVPDLLEAHVLYASSKPEANQKLPAADVAVFHTFLRQQASLLTQYPLLLLQQAASQPEESPVCCQAPLLTQRWHDQFTLKWINKPQTLKGQQSLSLTMSSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTTFDGHLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYTHPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGRPRGCLGSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWLSPSVLVSGAEDGSLHGWMFKGDSLHSLWLLSRYQKPVLGLAASRELMAAASEDFTVRLWPRQLLTQPHVHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQAPLLIHTFSSCHRDWITGCAWTKDNILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVVAVEEHIVSVSRDGTLKVWDHQGVELTSIPAHSGPISQCAAALEPRPGGQPGSELLVVTVGLDGATKLWHPLLVCQIRTLQGHSGPVTAAAASEASGLLLTSDDSSVQLWQIPKEADDSYKPRSSVAITAVAWAPDGSMVVSGNEAGELTLWQQAKAVATAQAPGRVSHLIWYSANSFFVLSANENVSEWQVGLRKGSTSTSSSLHLKRVLQEDWGVLTGLGLAPDGQSLILMKEDVELLEMKPGSIPSSICRRYGVHSSILCTSKEYGLFYLQQGDSGLLSILEQKESGEFEEILDFNLNLNNPNGSPVSITQAKPESESSLLCATSDGMLWNLSECTSEGEWIVDNIWQKKAKKPKTQTLETELSPHSELDFSIDCWIDPTNLKAQQCKKIHLGSVTALHVLPGLLVTASKDRDVKLWERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDTQGNLYFLSWE