wanglab/gogpt-training-data huggingface dataset:
Protein: BH3-interacting domain death agonist (Q1LX52)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
- Caspase 22, apoptosis-related cysteine peptidase
- Caspase 8, apoptosis-related cysteine peptidase
- Granzyme 3, tandem duplicate 4
- Granzyme 3, tandem duplicate 3
- trypsin
- Granzyme 3, tandem duplicate 2.
- Caspase 2, apoptosis-related cysteine peptidase
- Calpain-1 catalytic subunit
- Calpain 2
- Mitogen-activated protein kinase 8
Sequence:
MDFNRNFDHIPHTSLVLLSFLDQKDCQNGESGRVFDYREDNLSTNHIDSDGDIETDGQSPPATYRDLLHELQHEVQPGLSVNAEEARAAREMAAELIRIADLLEQSVLSQAAESLTKKLRSSQEQVWASHLSKGVQTLLQHVAAAKEFKKELVEMAFTFMLMKTVCERTPDFLFGLYGTVVQFFGSN
Protein: cAMP-inducible prespore protein D7 (P54682)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MYSKKYTSFVIVLILSCIISTCTSNQISEDVGKAINQKLNENIEKVEDVVVQFENVANQVIEELKVEHQRQELLGEVKHDSLRDSATNYIWGLLDKIQSYLPKDNNKVSKVEEAFSSGQNNNIGSSIGDSTGASTSPQFQSINGLSGASQSSGSSTGGTGDSDSKTTNEAIIFSSKVSTTDRQESIIGQVAITAKDSLGATITGLGGVSSTAKVGGQITNGRAQGQVITGGDNTGTVGRGAVTTASSVANTVGEFLGGSRTGGSSSAGTVGNVISDSYTSIGKIASGNGNSLSETIGTTGDTLAHTFAGTDSVGVTGFHIITKTFNLIAGGKFNSDQQYIDKSYGSIPSQDNEEIKKRLQSAHQQLQEQSPAIYQSMKSEDLKNLDDEVIRNTLKEMQIQRENQDIGQQNQEDKEQLIDLQNREPGLYKNQQDLKQEKRANQQELINYELNLQEDQEQYELLLDQLYDEQQQQPQKVSNKQQLQEQQINSPEDIQYQLNHLNQPFQDDYHNDQTEELKDDDYNFNDQQINNGQFENNVEEFPDLNDANDNFEQVNNNNNNINNNNNNNFKVDKSKKSAQQVEIALENERLYLQEVEDAPERLYEEIHNSNLNKAVQEAEEIERQQNGNGSPAVNSHKIVTQMGNVENNEITNEQDAIEQAQHLQRIENGEDIDEYEAAQHEVAFLDENEQDAAKLQNEMDQLELLLEENEEEQFSNKNLQQLNENENQQQQQGQQQVQATNVEQQIVEQLKVIKEFQRQDQQKKQKIQQENDAVYLSDVEKAQLELDAELAKNNKQENQDENLVQEKQQSPDQIKNQLKNIQHEQQIQEQQDKLNQEKNQQLLEQEQNQK
Protein: Rab GTPase domain-containing protein (Q54T92)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- ComD
- Cyclic AMP receptor-like protein D
Sequence:
MQQLDKSLKILIIGDNGVGKTSLLLRFTDGVFNPNEPTVLLEAKFKSVEVAGKSHKLQIGDTFGQEKISNLTSSFYKGAQGLIIVYDSSNRESFEKITSKWSIEAKRYVPVNTPILVVGCKSDLEKKTPPEMVRSFCLLNKFIGIECSALRNENIDLIFLTIAKMIITPHQFGLVGNNSITPTITSSSSSSTNSTTTMSVSSPSARSSKRDHSGSFGSGSGMNLINSNNIGKEKEKEKEKEKEKEKEKEKEKDPKKKEKGLFNKFFSSSSSNSNSNNNNNNNNNNSNNNNNNNNNNNNNNNNNSSSSPSLQPLNSSNHYIFSGSISGGSNRDQLLSSNGLREQDSNSLSVNSNSGLASSVNSVSSTSSGSNLLTSSNSSVNNNSNNSNSINNNNVNNNININNNNNTNNTNNNNIINNNNININENSTSGINSNNSGNNINNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNTNSINNNNNNNNNNNNNNNNNNNNNNNNNNSSISNNNNNNNNNNNNNNNNNNNNNNNNNNSSSSNNNINNNNINTDNNSSNNNNNNMNNNNNNNSGNNKNDKNDSNGSIKKKGVFKNLKNSGDKEKDKEKEKEKEKEKEKEKEREKEKEKENAKGVTSPKNILPINLNSSFLPNNNGNNGTTSIKDSGFFNNGMGSSGSSIGNTPTTTEENFKRRRHQILSVPFPSRPPFKDSNGRINYYRVCSNEVANSLNTTSTSPTLDGSSTNINTISITTTTTTTTTTSTVSSTNNNNSNNNNNNNQLQPPQTPTSSSLSVNQPFNLNSSTNINNLHNYVNALNLQQQQAQAQQLAQQLAQAQAQQHQYDLQQQLQQQQQQQQQQQLNRSPVIISTPSFITPVPPPPPTQSQQDQLRQQPPIKISSSPSPEVDYDNAYNQAYGFQPSEDEQKNWHRNTLEVLPSIASKSSLRHSSALPREPPPPTPSSIVNSTTIQPIDNNSNNNNNIINNTNGIGFNKAFPTSRDPINRGNSVVLGGIMQSNITISNNQNNNNNNNNNNIINNINNNENNNNNDDDDNKNNNNNNNNNNNNNNNNNNNNNNDNNVTIVEPPPTLTRTVTASTLNSQLNAFLNNMNENNNNNNNNNINNNINNNNNNNNNNNGTTKPIAIVNNFTLNRANMNTSVVGEQHGFLNINSVAKTGMSLSSNSMAIFSAVDNPNSPNQNNQNPYDTESIISGYDRDDLSEYDSENEESRQQTIHRSTSTFSIQSPSRGDRVLNRAESNFITSVNSSNNKQTSQPLRDDIKSNSSDKLLQQPDNIDPYEIQQNKQSNNSNSNSNRNLTPNSSSPTNQRKNKQEDDDDESKLDDESDLNERFQKVVLRFREFPSLDTNLYRLQEICTDLLHISQDFIHTVKTYGRIIIEERYLKEKTIQSRSIGGHLGGDKYIVRNVLFKFSGSSNVYDEWGGAKVGGQELKGCMATLNCPIGGLCVPLMALVDFMGFRLIAMSYLPIISSGEKSTIVYGSSDMGKTVHANEKALPIMHSLSQMLNLKPHLGGTSVPPTLLYSATDIEGHIGTDGRFYLIDFSRTFPPTYPDENVPGGHLFQLFRPEFLKNHPKPLCSDAFSGFIKNDKDRLIHNQEVKEASNRLLTELIPRLSVRLKWMIKESLNNGTLLTGDVHIPEQFHRQGINMRWIGHMLVIMDDRDACFVLLIEAIARVLKNDLRRRLRSAMKRYNQPLSAPYIDLTTKFLNMVFGISTLTDFDTNEFWNVTVKNELASKFYIINIPTVLTMHKQQQQQNGSSGSLGTNTSSDNVLDLTTNGNGNLNNSGSGYPTTPSSKDGGIRKSTQYPLAPASPTIQSTQTQQQQQAQQQAQQQASTNGWKLQEILYEKLEGNNYDPVIGRHLLFTRFRDMTHLKFRKKTIEKVADTQSNLWNHYQPFDTSDLKKIGVRVKHTDLVTNAEGTFFYAKAMTERSIGTAIHLLHKARKFFELALISNPNNKETLQLCAQAWCKILEFSASQGKNMSNVRFSMSDRVVVNTDRYFLRAIDADTKGPLILFFYANFLVRCERYEKAEDYFLRSLEADSNNYRCLTAYANFLIERGFPNESSLFLERAKQCKAILVGGFKN
Protein: MARVEL domain-containing protein (Q21228)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDRREVYTTQQPDGTYVTTTTREKTKYKEHSVWSCGHGPTDKNYCLGPLGLLRIAEIFLCVVIVCLITSVFGPGPFKGILFGQTILLTVASVAMLLTFIFLIAYFFTLHLSHLDFFCWREADLLFNVICAVLFIVLSIVEAYYSTGSWSNNCNDIGSDGIIHNGCRIIYEWAFASFLTFILGIFYALTAFLTHKNRHSLRNISREELY
Protein: FACT complex subunit spt-16 (Facilitates chromatin transcription complex subunit spt-16) (Q9N5R9)
Organism: Caenorhabditis elegans
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity). In embryos, promotes cell cycle progression and chromosomal segregation. Plays a role in the development of the anterior pharynx during embryonic development.
Subcellular location: Nucleus {ECO:0000269|PubMed:30336114}. Chromosome {ECO:0000250|UniProtKB:Q9Y5B9}.
Interaction partners:
- FACT complex subunit SSRP1-A
- FACT complex subunit ssrp1-B
- Transcription elongation factor SPT5
- Cell division cycle protein 73
- Transcription elongation factor SPT4
- RNA polymerase-associated protein CTR9
- DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
- Suppressor of Ty 6 homolog
- RNA polymerase-associated protein LEO1
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MSGKRAVLNKDLFFQRAERLYEHWEKGADGLDSIKSLAFVYGETDNPYTKTSALFTWLFGHEIADTVLLLLKDHIYILGSNRKVEFFGSVTGDNQSSGKVPTVSTLLRDKTDKDAGNFEKLIDHIKSAGGDVGNFVKEKFSSEFVSSWNKALEEGGVNKNDVTLAFTHLFAVKDDKEMDLIRKSAQATTASWTAARARYVEIIDQEKRVRHSVLSNEFAAFMKDSKVQQALAKYEADTCYDPIVMSGGNYSFKWNHESSESHLHSQFGTIITSFGARLSEYCTNLTRTMLIFPSSELETAYEAILAAELAVIAALKPGAKLSDVYKIGIDTLTEKSPKLAETLNKKELGFATGIEFRESRLAISAKCDEVVKAGMVFIVYIGVDSIPNKNKGEKGKPAAIAISDTILVKEEGDNEILTEKAKSRLKSNVIKFKEEQENREAEKDNDQKKMLGRGQRSVVLTDQTRNKTTNEELRKERQKELGVQLNELAKARLSKQGGGTDEKKSKKSNVSYKTEERFPQDADVQKMLIFVDRKYDSVVVPIFGIPVPFHISMIKNCSQSVEGDFTYLRINFATPGSQVGKDSGQFPHPLAHYMKELTFRASNIKDHHSDSTAPSHNLSTAFRLIKEMQKRFKTEEAEEREKEGAVKQDKLILSQNKLNPKLKDLLIRPNIIQKRITGSLEAHTNGFRYTSLRGDRIDVLYNNIKHAFFQPCDNEMIILLHFHLKNPVLWGKKKYKDVQFYTEVGEITTDLGKYHHMQDRDDMQSEQQEREMRRRLNAAFNSFCEKVSRLTNDQFEFDSPFAGLGFFGVPYRSATTLKPTASCLVNLTEWPTFIVTLSEVELVHFERVSLQLKNFDMVFIFKDYKIKPQMVAQIPMSSIDKIKEWLHTCDIWYSEGIQSLNWAKVMKTITDDLEAFFEEGGWSFLNVESDNEEAMDDSDDSDAYDPEEEDASAGSGSESDEDESEGEETESDDDDEGSLDSDESEGKDWSDLEEEAANADKRREVEEPSRDRDRKRPHSSKSGPSHKRRK
Protein: RNA polymerase II C-terminal domain phosphatase-like 4 (FCP-like 4) (EC 3.1.3.16) (Carboxyl-terminal phosphatase-like 4) (AtCPL4) (CTD phosphatase-like 4) (Q00IB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Processively dephosphorylates 'Ser-2' and/or 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II (By similarity). Required for normal plant growth.
Subcellular location: Nucleus {ECO:0000269|PubMed:16905668}.
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- Protein POOR HOMOLOGOUS SYNAPSIS 1
- Protein gamma response 1
- Protein PUTATIVE RECOMBINATION INITIATION DEFECT 1
- Type 2 DNA topoisomerase 6 subunit B-like
- Putative recombination initiation defects 3
- Protein MULTIPOLAR SPINDLE 1
- DNA-directed RNA polymerases II, IV and V subunit 3
- DNA-directed RNA polymerase II subunit 4
- Meiosis-specific protein ASY3
Sequence:
MSVASDSPVHSSSSSDDLAAFLDAELDSASDASSGPSEEEEAEDDVESGLKRQKLEHLEEASSSKGECEHPGSFGNMCFVCGQKLEETGVSFRYIHKEMRLNEDEISRLRDSDSRFLQRQRKLYLVLDLDHTLLNTTILRDLKPEEEYLKSHTHSLQDGCNVSGGSLFLLEFMQMMTKLRPFVHSFLKEASEMFVMYIYTMGDRNYARQMAKLLDPKGEYFGDRVISRDDGTVRHEKSLDVVLGQESAVLILDDTENAWPKHKDNLIVIERYHFFSSSCRQFDHRYKSLSELKSDESEPDGALATVLKVLKQAHALFFENVDEGISNRDVRLMLKQVRKEILKGCKIVFSRVFPTKAKPEDHPLWKMAEELGATCATEVDASVTHVVAMDVGTEKARWAVREKKYVVHRGWIDAANYLWMKQPEENFGLEQLKKQLTEEE
Protein: 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267) (F4K7T6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTLNSLSPAESKAISFLDTSRFNPIPKLSGGFSLRRRNQGRGFGKGVKCSVKVQQQQQPPPAWPGRAVPEAPRQSWDGPKPISIVGSTGSIGTQTLDIVAENPDKFRVVALAAGSNVTLLADQFSGSIISKIVLTRYVSDQTREIRRFKPALVAVRNESLINELKEALADLDYKLEIIPGEQGVIEVARHPEAVTVVTGIVGCAGLKPTVAAIEAGKDIALANKETLIAGGPFVLPLANKHNVKILPADSEHSAIFQCIQGLPEGALRKIILTASGGAFRDWPVEKLKEVKVADALKHPNWNMGKKITVDSATLFNKGLEVIEAHYLFGAEYDDIEIVIHPQSIIHSMIETQDSSVLAQLGWPDMRLPILYTMSWPDRVPCSEVTWPRLDLCKLGSLTFKKPDNVKYPSMDLAYAAGRAGGTMTGVLSAANEKAVEMFIDEKISYLDIFKVVELTCDKHRNELVTSPSLEEIVHYDLWAREYAANVQLSSGARPVHA
Protein: Cilia- and flagella-associated protein 20 (Q6PBJ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. {ECO:0000250|UniProtKB:Q6B857}.
Interaction partners:
- Fumarylacetoacetate hydrolase domain-containing 2A.
- ADP-ribosylation factor-like protein 2-binding protein
- Protein broad-minded
- PARK2 co-regulated.
- EF-hand domain
- EF-hand domain-containing family member C2
- Cilia and flagella-associated protein 45.
- Enkurin
- Cilia and flagella-associated protein 52.
- Tektin 2
Sequence:
MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEVEGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQNKAK
Protein: Transglutaminase y (EC 2.3.2.13) (Q6YCI4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGVRITKVDWQHSKNGAAHHTQDYPCSELVVRRGQLFSLTLDLSRVLDSEEALIFTVETGPHASEALHTKAVFQTAELEIGDTWTAAKEEQTENTITVSLLSPSNAVIGRYLLSARPSSRRKHSDRKLGQFILLFNPWCPEDDVFLDSEEERQEYVLNDSGVIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPSHQEDPATDVSHRHDPVYVTRIISAMVNSNNDRGVVQGQWQGKYGGGTNPLNWRGSVAILQKWFKGRYKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTDGNLSVDKYVDSYGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYDGWQVLDATPQEESEGMFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDKRRERVYSDTKKIGRCISTKAVGSDSRVDITGLYKYPEGSRKERQVYSKAVKKLLSVEAWGRRRRIRRASVRGVWRDDLLEPVTKPSITGKFKVLEPPVLGQDLKLALCLTNLTARAQRVRVNVSGATILYTRKPVAEILRESHTVKLGPLEEKKIPVTISYSQYKGDLTEDKKILLAAMCLVSKGEKLLVEKDITLEDFITIKVLGPAVVGVTVTVEVLVINPLSESVKDCVLMVEGSGLLQGQLSIEVPSLQPQEKALIQFNITPSKSGPRQLQVDLVSSQFPDIKGFVIIHVATAK
Protein: Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) (Q10901)
Organism: Caenorhabditis elegans
Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- glutamine synthetase
- glutamine synthetase
- Probable glutamine synthetase
- Glutamine synthetase
- glutamine synthetase
Sequence:
MPPDTRINKEIMVSWIRKNLLLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILPLIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGTGTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGSLDYVKASVEYTSGMNVLGVIVFCIAIGISLSQLGQEAHVMVQFFVIMDKVIMKLVMTVMWYSPFGIFCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFVTTKKNPYVFMRGLFQAWITALGTASSSATLPITFNCLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVYHYSKADLDAHDRLAATTRSHSIAMNDEKRQLAVYNSLPTDDEKHTH
Protein: Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (Os60SP0p) (P41095)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Interaction partners:
- Os08g0116500 protein
- 60S ribosomal protein L2
- 60S ribosomal protein L29
- Small ribosomal subunit protein uS9
- 40S ribosomal protein S12
- 40S ribosomal protein S12
- 40S ribosomal protein S29, putative, expressed
- Os07g0180900 protein
- Large ribosomal subunit protein uL3
- Ribosomal protein L3
Sequence:
MAIKRTKAEKKVAYDKKLCQLLDEYTKVLIAVADNVGSNQLQEIRKGLRGDSIVLMGKNTLIRRCIKVHADNTGNKEFLELMPLLVGNVGLIFTKGDLKEVREEVAKYKVGAPARVGLVAPVDVVVPPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKKGDKVGSSESALLAKLGIRPFSYGLVITNVYDSGSVFSPEVLDLTEDDLMEKFASGVSMVASVSLAISYPTIAAAPHMFLNGYKNVLAVAVETEYSYPHADKIKEYLKDPSKFAVAAPVAADSGAAAPSAAKEEEKKEEPEEESDGDLGMSLFD
Protein: PIN domain-containing protein (Q9BL68)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Regulator of nonsense transcripts 1
- UPF3 domain-containing protein
- Nonsense-mediated mRNA decay protein
- DNA/RNA-binding domain-containing protein
- Nonsense-mediated mRNA decay factor SMG9
- Serine/threonine-protein kinase smg-1
- Nonsense-mediated mRNA decay factor SMG8
- MIF4G domain-containing protein
- 5'-3' exoribonuclease 1
- Nuclear cap-binding protein subunit 1
Sequence:
MNGDTDASSSRTGAPRKPRPEIQIYRPGMLRQGGSTKSLSSTNEEARPPRPEKLNTTTTTMSGNSRRRSNDTDSVTSRGGSGSTTPDANVINAMNERGGGRNRFEKGYRQQQRTDGPSNYNSTQSLYDTRQHGGYMEYQGNHRSNHRNNGRYSNQQHQQHRQPFERPGGNHYTRGFNERASMRGDGAIARRPQGSRRQRNDSINSTQSEMPPQTGAQLHIDTSFDSASQCGASSNFSMNSLGEAFSFEEMCQNLQNFASMDWSKEVENEFAMQKEQEEEEERRMEQKLQEAAAQEAQKAASPRRNNRRNNRRGGGNSRYHPDESDRESSFGGSIAEEKEEEEAEEELKSGERTPTSVRSGNSYNPRVLYQRTRGANDENHPKRRDAAVEKKPKEPRRYRGEHDDRDDDASEYHGTLENHMSSGRLAGRIQIVQRSQNGTEAGGNRNRQSSEEKPRTYQKRSQNQSEMANRAEINRRRQEDIDRNEGKQIREISEKIEKLSAPVKKRDLKSAEKMAEISMELANIYSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGSNSAAPDARLIRAVTQKLLLNGIVYYENLIATYETQFHVALTDALTWQSGSPSDEELCEQYIELPIGIQKFDSATQKTAIKSLSRHLISLGDLHRYKSLIDGSENYEISKSCYQKSSQLWPSTGHPYNQLGIVVYYSMLYRSARRARLVPVDVLSRQRQKRVIDEFFCLTRALACSHPYEVAKDRLKQRIDAMRTKVAKYQPVLDKESGIVKEQGNVLRRLQRIRQIWIHPITETSQDGTGERIVDDVLVHFMEHSKAKLHRRAVSYLCDTFGMLVTKIGMDHFESVSERAFGLLYASLSKSETDFSADQLVKFSAMFIYAAQVNFDKSTPSTSKSQLHTAVRTIFTYFLVLLEHISTHTTLLLPAANVIATWILHADTEELLSYLEHLEPLSSTIISSFSNFPPNLESEAENPENVTTPEAILLASFFKIYEPNPTPVRCSRSTNISQAVEKLKILGFSAEKSEKSGENGKQKLGDGLEEPKSREQMIDEQRGLGKTTIVIHPEYLIPDTNVLIGDLQLMKNLLETAQKNKKFQILVPTTVLDELQYIAKLSPLDSKSNSEAHDPERISKAKIAVAWLKEQAKQKTGHLYTLTTTGKRLPTLSIVSEDLEGHEMTTNDDMILNSALRWSESLPGSTAPSATEISQKCVLITGDRGLTIKAIGNNFPCRGISNFTKWIINV
Protein: Tyrosyl-DNA phosphodiesterase 1 (G3V5B8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEG
Protein: WW domain containing transcription regulator 1 (Q4V7E6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcriptional enhancer factor TEF-3
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Angiomotin
- TEA domain family member 2
- Transcriptional enhancer factor TEF-5
- Tight junction protein ZO-1
- TEA domain transcription factor 1
- Beta-transducin repeat containing E3 ubiquitin protein ligase
- Transcriptional coactivator YAP1
Sequence:
MNPSSVPHPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKVMNQPLNHVNLHPTITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPAQNPPTGLMSVPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNTPAMNTDMRSVTNSSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDTGENSGQTPMTVNPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL
Protein: Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form] (P78380)
Organism: Homo sapiens (Human)
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Subcellular location: Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.
Interaction partners:
- Heat shock 70 kDa protein 4
- C-reactive protein
- Apolipoprotein B-100
- Scavenger receptor class B member 1
- Lysosome membrane protein 2
- Platelet glycoprotein 4
- Immunoglobulin lambda-like polypeptide 5
- Protein-lysine 6-oxidase
- Macrophage scavenger receptor types I and II
- 60 kDa heat shock protein, mitochondrial
Sequence:
MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ
Protein: Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7) (Q05941)
Organism: Rattus norvegicus (Rat)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:17510177}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15927954}; Multi-pass membrane protein {ECO:0000255}. Note=RIC3 promotes its trafficking to the cell membrane (PubMed:15927954). TMEM35A/NACHO promotes its trafficking to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P49582, ECO:0000269|PubMed:15927954}.
Interaction partners:
- Neuronal acetylcholine receptor subunit alpha-2
- Neuronal acetylcholine receptor subunit alpha-3
- Neuronal acetylcholine receptor subunit beta-2
- Basic helix-loop-helix family, member e23
- Acetylcholine receptor subunit beta
- Neuronal acetylcholine receptor subunit beta-4
- Acetylcholine receptor subunit epsilon
- Neuronal acetylcholine receptor subunit alpha-5
- Neuronal acetylcholine receptor subunit alpha-6
- Acetylcholine receptor subunit delta
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Protein: Poly(A) polymerase pla1 (PAP) (EC 2.7.7.19) (Polynucleotide adenylyltransferase) (Q10295)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I).
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Pre-mRNA polyadenylation factor fip1
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- NURS complex subunit red1
- mRNA 3'-end-processing protein yth1
- Protein cft1
- Polyadenylation factor subunit 2
- Cleavage factor two protein 2
- Endoribonuclease ysh1
- Polyadenylate-binding protein 2
- Uncharacterized RNA-binding protein C644.16
Sequence:
MTTKQWGITPPISTAPATEQENALNTALINELKNQNLFESPAESEKRVKVLDELQQITTEFVKKVSLAKHMNEKMANEAGGKIFTYGSYRLGVYGPGSDIDTLVVVPKHVSRDNFFQDLEPMLREREEVTDLAAVPDAYVPIIKFKFLGISIDLIFARLSVPRVPRDLELSDNNLLKGVEERCVLSLNGTRVTDQILQLVPNRAVFKHALRAIKFWAQRRAIYANVVGFPGGVAWAMMVARICQLYPNAVSSVIVAKFFRILHQWNWPQPILLKPIEDGPLQVRIWNPKLYPSDKAHRMPIITPAYPSMCATHNITLSTQTIILREMVRAGEIADQIMVKALPWSALFQKHDFFHRYKHYLTITAAAKTAEAQLKWAGLVESKLRHLVTRLELVDAIALAHPFNKGFDKVYNCSSEEEAQQVASGVTLEVAYESTDHEKLANDTVNEEKADNTESKADGSENGEKQIFPVYTTTCYIGLELEKKKGHPIKRLDISWPTQEFYELCKKWDKYDDTLMNVFIKNTKNTALPDEVFEPGEERPKATKKRSTADTAHSTEQLKRQKVSTA
Protein: NAC domain containing protein 52 (ANAC052) (NAC domain containing protein 51) (ANAC051) (Protein POLLEN DEVELOPMENT DEFECTIVE 1) (Protein SUPPRESSOR OF GENE SILENCING 1) (Q9SQY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes. Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin. Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR). Together with NAC050 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing. Regulates siRNA-dependent post-transcriptional gene silencing (PTGS) through SGS3 expression modulation. Required during pollen development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:26617990}.
Interaction partners:
- Lysine-specific demethylase JMJ14
- Histone H3-like 4
- Histone H3-like 3
- Histone H3.3
- Histone H3-like 2
- Histone H3-like 1
- Histone H3-like 5
- Histone H3-like centromeric protein CENH3
- Histone H3.1
- Leucine-rich repeat protein kinase family protein
Sequence:
MGRESVAVVTAPPSATAPGTASVATSLAPGFRFHPTDEELVSYYLKRKVLGQPVRFDAIGEVDIYKHEPWDLAVFSRLKTRDQEWYFYSALDKKYGNGARMNRATNRGYWKATGKDREIRRDILLLGMKKTLVFHSGRAPDGLRTNWVMHEYRLVEYETEKNGNLVQDAYVLCRVFHKNNIGPPSGNRYAPFMEEEWADDEGALIPGIDVKLRLEPPPVANGNDQMDQEIQSASKSLININEPPRETAPLDIESDQQNHHENDLKPEEHNNNNNYDENEETLKREQMEEEERPPRPVCVLNKEAPLPLLQYKRRRQSESNNNSSRNTQDHCSSTTTTVDNTTTLISSSAAATNTAISALLEFSLMGISDKKEKPQQPLRPHKEPLPPQTPLASPEEKVNDLQKEIHQMSVERETFKLEMMSAEAMISILQSRIDALRQENEELKKNNANGQ
Protein: Stretchin-MLCK (Q9NBC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
SVSCHCTLVVDKGIRAYISPDFYVPLDPFYIFREGSEIRLSTKVEAYPSVGVTWHRNGMRLRPSRRLTATLDSNGYVELIIAEATVRDAGIYVCVAXNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDLPYSKEPLFVVKPRSSEAYEGDNVIIFCEGGGDPKPEVVWLRDFLNPEYYKDAPHFRRIGDGPQYRLEIPSAKLDFTGTYSVIASNCHGETKAVISLQIFAKDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDGDAISLECHV