wanglab/gogpt-training-data huggingface dataset:
Protein: Signal recognition particle receptor subunit beta (Q586V9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
- Signal recognition particle receptor alpha subunit, putative
- Signal recognition particle 54 kDa protein
- SRP19 protein
- Signal recognition particle subunit SRP68
- Signal recognition particle subunit SRP72
- 60S ribosomal protein L4
Sequence:
MLLIAVTIIVALLVAYYISTLFSAVRGTTRRRSRSVLLVGLTGSGKTTLFAQLVARKRVQVRTSMEPNRGVMRLASAAENEDPTAGSESSGVTIIDFPGHRRLRESLMRALEEVKKVVFVVDAVTIQDPHEGAEAVAELIVAVLSSTEFFGVESVLIACTKRDELTSYSAKAVQKLLEKEITHCLSTRHGGVQRLESIVNASGVAVGSGNKSRRNAATHGCRSHELSLDEARKFSFANFQVPVQFVDISSFVGPEDQVYNVEPVREFATS
Protein: RE65532p (Q8SYE1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPRKLLKFLIIFDNTSLLYFPGQFLSGRVLIELQDETPALGLHFHVVGEGVVRNGRRQERTYDKENYIDFRMRLLGDVDQGGPAILSPGIHSFPFKLGLPLGLPSTFLGRYGWIQFYCKAALRENNGIIHKNHQVFIVMNPIDLNLEKPILAQPFTCEVEHKLGVVCVSGGQIKCRVSLDRGGYVPGENILVTAFISNYSNVSIKRTKASLTETIEYLARGKVVQTEKRELAVLVRGKIRPGAKDEWHNELYVPPLPPTNLHGCRLIKISYDVFFVIEPKSMEKEIKLQLPIVLATYPFRHSGDAVNANTWPESVLKPDTHTHYPSTLPIFRPWLHEKPIEA
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q9I9P2)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
PSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPSTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVR
Protein: L-fucose dehydrogenase (EC 1.1.1.122) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1) (Q9BPX1)
Organism: Homo sapiens (Human)
Function: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17067289}.
Interaction partners:
- 17-beta-hydroxysteroid dehydrogenase type 3
- Very-long-chain 3-oxoacyl-CoA reductase
- 17-beta-hydroxysteroid dehydrogenase type 1
Sequence:
MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS
Protein: Endothelial transcription factor GATA-2 (GATA-binding protein 2) (O09100)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Subcellular location: Nucleus.
Interaction partners:
- T-cell acute lymphocytic leukemia protein 1 homolog
- Runt-related transcription factor 1
- Rhombotin-2
- LIM domain-binding protein 1
- Transcription factor PU.1
- Zinc finger protein ZFPM1
- Erythroid transcription factor
- Transcriptional activator Myb
- CCAAT/enhancer-binding protein alpha
- Protein lyl-1
Sequence:
MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYGSSLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSPPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG
Protein: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Cholesterol-5,6-epoxide hydrolase subunit EBP) (EC 3.3.2.11) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) (Q15125)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10406945}; Multi-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:10406945}. Cytoplasmic vesicle {ECO:0000269|PubMed:10406945}. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. {ECO:0000269|PubMed:10406945}.
Interaction partners:
- Lathosterol oxidase
- Delta
- Delta
- 7-dehydrocholesterol reductase
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Voltage-gated inwardly rectifying potassium channel KCNH6
- Arylsulfatase L
- Acyl-CoA
- Squalene synthase
Sequence:
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
Protein: RE13953p (Q8SZ82)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
Interaction partners:
Sequence:
MNVLLRCTFLLLTLAICGSWAIRCYQCSSDQDRKGHDSCGAYKRFNRTEHISIECNSDESHMPGSFCMKVVQQGPRGFIWDGRWRQVIRRCASVSDTGVVGVCNWGVYKNGVYWEECYCSSDSCNGSSLVQMHGSLQLLLGLLLIGVASRIFRS
Protein: Rifin (Q8I642)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYINILLFALPLNILIYNQRNHNSTTHHTLKIPITRLLCECELYSPSNYDNDPQLKKIMENFNKQTQQRFEEYDERMKTTRQKCKDKCDKEIQKIILKDKLEKELMDKFATLQTDIQSDDIPTCVCEKSLADKVEKNCMKCTQNLGGIVAPSSGVLAGIAELGLNAWKTTEITAAIAAAEQAGAAKGLAAGAAKGVAEVIAQVESQFHLSTIGVNELGSVINVTNYNNSQFIFKAIFTKYRGSCLPSPPDRLTVAAGEETFCRTVNALGFTRRNVFDPSLLQDSIKSVGNQIVTKAETAASTETAKVTASETATLKAAKVGEVNATYMGYQTPIIVSIAAIVVIVLVMVIIYLILRYRRKKKMKKKLQYIKLLKE
Protein: Probable leucine-rich repeat receptor-like protein kinase IMK3 (EC 2.7.11.1) (Protein INFLORESCENCE MERISTEM RECEPTOR-LIKE KINASE 3) (Protein MERISTEMATIC RECEPTOR-LIKE KINASE) (C0LGP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Can phosphorylate AGL24.
Subcellular location: Cell membrane {ECO:0000269|Ref.8}; Single-pass type I membrane protein {ECO:0000269|Ref.8}.
Interaction partners:
- MADS-box protein AGL24
- Gibberellin-regulated protein 13
Sequence:
MEFITQNQAITSLSMINTDIDQPKASLRSRFLLHLIICLLFFVPPCSSQAWDGVVITQADYQGLQAVKQELIDPRGFLRSWNGSGFSACSGGWAGIKCAQGQVIVIQLPWKSLGGRISEKIGQLQALRKLSLHDNNLGGSIPMSLGLIPNLRGVQLFNNRLTGSIPASLGVSHFLQTLDLSNNLLSEIIPPNLADSSKLLRLNLSFNSLSGQIPVSLSRSSSLQFLALDHNNLSGPILDTWGSKSLNLRVLSLDHNSLSGPFPFSLCNLTQLQDFSFSHNRIRGTLPSELSKLTKLRKMDISGNSVSGHIPETLGNISSLIHLDLSQNKLTGEIPISISDLESLNFFNVSYNNLSGPVPTLLSQKFNSSSFVGNSLLCGYSVSTPCPTLPSPSPEKERKPSHRNLSTKDIILIASGALLIVMLILVCVLCCLLRKKANETKAKGGEAGPGAVAAKTEKGGEAEAGGETGGKLVHFDGPMAFTADDLLCATAEIMGKSTYGTVYKATLEDGSQVAVKRLREKITKSQKEFENEINVLGRIRHPNLLALRAYYLGPKGEKLVVFDYMSRGSLATFLHARGPDVHINWPTRMSLIKGMARGLFYLHTHANIIHGNLTSSNVLLDENITAKISDYGLSRLMTAAAGSSVIATAGALGYRAPELSKLKKANTKTDVYSLGVIILELLTGKSPSEALNGVDLPQWVATAVKEEWTNEVFDLELLNDVNTMGDEILNTLKLALHCVDATPSTRPEAQQVMTQLGEIRPEETTATTSEPLIDVPEASASTSQ
Protein: IQ and ubiquitin-like domain-containing protein (Q57Y89)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDGDDGMPPSEHSGTPFSQFEEDQEQEDLLREEIPEEAGESELPEGDDQTDIALLPNDSEYAANTSELEGFGTEVRTTDMELEDSVDPELDMVGAEVAPVTKPSESVEELPLTAQAVDSELADVMPEREQPSYGVQTQLDVEDITEESSQQPTAESSEVEAHQLSPNEYIVSADIEVSVFVTVQPMGFQVTVKAPGGSRGDVYSGFLYECIASRFGVHPESLRLRWRGERLRFGVTVPYEAGPGPREGRLWIDAFFNEGMIPEHLMSIEKDNHYVRCVTVRARLEQIGPSDLISARRRGLTFDEAINEVRESTKPQNYMTISIVHDPMGIRLPFLGGYRLKKDHSRIFRHAATQLSSPGDTTLADLQYGPIVRNRVSRKTQTYGVSRSTQTLREGRTQTARPDYEVDEKFDEAITAKPYFSSQELLALQSTMIVVIQKMYRKWKARRVFREVAALRQDFLNKAAQQAAEEEAEKRRREEFELRRRAVPRTADDFKTLRKELEAWRAAEAERILADTSLSEAQKRTALTHLTNKEVKLLRELETLRGTVLNNRRMHRFETILQAMTCAKDCGPVSVTTQAAERACELRQLYASFTEPPKTVEGRLDILLHVKWTVKEFDVPLTRQIVELIDREADLLQRGRTMCSLKGLHTRLENLLKRFIATPEYNPAVEEVVRGPKFGVADGLDAPKISSSRRLKPSNVL
Protein: Glial fibrillary acidic protein (A0A1W2PR46)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEGTKQLRTSTSGVWSLALVRSFLGTALEPQDTTSGTALRTLALTQEWVKGNRNEKGGPRCSGREISASVLQALPCQPGGKVFHQPGG
Protein: Multidrug export protein AcrF (Acriflavine resistance protein F) (Protein EnvD) (P24181)
Organism: Escherichia coli (strain K12)
Function: Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:11274125, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:11274125, ECO:0000269|PubMed:15919996}.
Interaction partners:
- Multidrug export protein AcrE
- Multidrug efflux pump subunit AcrA
- Outer membrane protein TolC
- Cation efflux system protein CusC
- Multidrug resistance protein MdtA
- Multidrug resistance protein MdtE
- Macrolide export protein MacA
- Multidrug export protein EmrA
- Multidrug export protein EmrB
- Macrolide export ATP-binding/permease protein MacB
Sequence:
MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAMALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRCFKG
Protein: Uncharacterized protein (Q57YC4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTLSSWLTGGKTGGGKESEKEDAAAIAARNELLNVIEGAPPSLVSQQADQFAFLRSNARHKIADVVLALTAYTFSGFIHMYGQSTALTTLSMWAAGTTFFLNMQVRKVFELEDETRRKQAVIDMGLQEKNVFQLEAVASWVWMLSSLQQFKIHKRLKYCGYSSWTALCCCTYFTFRHMYQMLLEA
Protein: Maturase (Q3L0X2)
Organism: Oryza longistaminata (Longstamen rice)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
PFDKPRNISLSLIQVEIQMEKFEGYSEKLKFPRQYFVYPLLFQEYIYVFAHDYGLNGSELVEIIGSNNKKFSSLLVKRLMIRMYQQNFWINLVNHPNQDRLLDYNNFFYSEFYSQILSEGFAIVVEIPFSLREQSCPEEKEIPKFQNLRSIHSIFPFLEDKFLHLHYLAHIEIPYPIHLDILLQLLQYRIQDVPSLHLLRFFLNYYSNWNSFITSMKSIFILKKENKRLFRFLYNSYVSEYEFFLLFLRKQSSCLRLTSSGTFLERIIFSRKMEHFGLMYPAFFRKTIWFVMDPLMHYVRYQGKAILASKGTLLLKKKWKCYLVRLWQYSFSFWTQPQRIHLNQLANSCFDFLGYFSSVPINSLLVRNQMLENSFLIDTQMKKFDTKVPVTPLIGSLAKAQFCTGSGHPISKPIWTDLSDWDILDRFGRICRNLFHYHSGSSKKKTLYRLKYILRLSCARTLARKHKSTVRAFMQWLGSVFLEEFFTEEEQVFSLMFAKTTYFSFRGSHSERIWYLDIL
Protein: Abcd4 protein (Q5FWT4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MQIRVNAEPAAFYRAGLVEHMRTDRRLQRLLQTQRELMSRELWLYIGINTFDYLGSILSYVVIAIPIFRGVYGDLSPTELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGELQEALLDMSRKSHDCETLGESEWDLDKAPGWPTTEPSDTAFLLDRVSILAPSSDKPLIKDLSLKICEGQSLLITGNTGTGKTSLLRVLGGLWESMKGEPALPASGTAWPQGGSVVGSQRWREEAVTLPARSPNGGFCGLCRLSADAG
Protein: Probable small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) (O82221)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable common Sm protein, is found in U1 and U2 snRNPs and may be part of the spliceosome.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein SmD3a
- Sm-like protein LSM8
- Small nuclear ribonucleoprotein SmD3b
- Small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein SmD1a
- Small nuclear ribonucleoprotein SmD1b
Sequence:
MSRSGQPPDLKKYMDKKLQIKLNANRMVTGTLRGFDQFMNLVVDNTVEVNGNDKTDIGMVVIRGNSIVTVEALEPVGRSS
Protein: Mad-like protein 1 (G5EG44)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mxl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and may overlap with the insulin-like signaling pathway. Plays a role in autophagy. Involved in promoting infection by the microsporidian pathogen N.parisii, possibly together with transcription factors pha-4 and zip-10.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:27402359}.
Interaction partners:
- Max-like protein 1
- Protein mxl-3
- Cell division cycle protein 27 homolog
- Abnormal embryogenesis protein 30
- Protein WBSCR14 homolog
- Max-like protein homolog 2
- Zinc finger transcription factor pqm-1
Sequence:
MEQQLNLGHLLTAARLLDIGALDISSLDLGALTSTSSSPGSSSPAMFDLSNESELRSLFCGKLKVDKKQSSCASNASTSSQPYCSSPPARKSSKHSRTAHNELEKTRRANLRGCLETLKMLVPCVSDATRNTTLALLTRARDHIIELQDSNAAQMKKLNDLRDEQDELVAELAQLQADEEVAQATSQACQTLSQSRPESRASSFTSTSSRDSPCYLEYSPSSKPMDSHKPTIIDLYAEGLIPRGPITFPRPLVYPHNVFDLMNLPPTPFDVSQFLPINLQV
Protein: Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (EC 3.6.1.8) (P0AEY3)
Organism: Escherichia coli (strain K12)
Function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the type II MazE-MazF toxin-antitoxin (TA) system which mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA.
Interaction partners:
- GTP pyrophosphokinase
- Antitoxin MazE
- Endoribonuclease toxin MazF
- CTP synthase
- dCTP deaminase
- NAD-capped RNA hydrolase NudC
- Nicotinate phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
- Bifunctional
- Trifunctional NAD biosynthesis/regulator protein NadR
Sequence:
MNQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL
Protein: Ornithine decarboxylase antizyme 1 (ODC-Az) (P54369)
Organism: Mus musculus (Mouse)
Function: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Interaction partners:
- Ornithine decarboxylase
- Gene model 853
- Antizyme inhibitor 1
- Antizyme inhibitor 2
- Peptidyl-prolyl cis-trans isomerase A
- Large ribosomal subunit protein eL27
- Polyubiquitin-B
- Eukaryotic translation initiation factor 5A-1
- Histone H3.3
- Large ribosomal subunit protein eL19
Sequence:
MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED
Protein: Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8) (Q8WXS5)
Organism: Homo sapiens (Human)
Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VHW2}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8VHW2}.
Interaction partners:
- Glutamate receptor 1
- Glutamate receptor 2
- Protein cornichon homolog 2
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Protein shisa-9
- Voltage-dependent calcium channel gamma-7 subunit
- Voltage-dependent L-type calcium channel subunit beta-4
- Glutamate receptor 3
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
Protein: LIM homeobox transcription factor 1, beta a (LIM homeodomain protein Lmx1b.2) (Q4L1M5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MLDGIKIEDQFRTGAETLGVMLGADCAHHQSVCEGCHRPISDRFLLRMNDSSWHEECLQCSVCQQLLTMSCYSRDHKLYCKHDYQQLFATKCSGCLEKISPTELVMRALESVYHLSCFCCCVCERRLCKGDEFVLKEGQLLCKTDYEREKDLASPDLSDSDKSEDEDLDVKPEKGAGGQGKGSDDSKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQEQQNSQRLGQDVMSSRMENLMSSYTPLAPPPPHALVSMESSGYSTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFMSASDAAALQSRVGNPIDRLYSMQSSYFTS
Protein: Dihydrofolate reductase (EC 1.5.1.3) (P17719)
Organism: Drosophila melanogaster (Fruit fly)
Function: By interacting with vestigial (vg), may control genes involved in DNA replication.
Interaction partners:
- Thymidylate synthase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Serine hydroxymethyltransferase
- Methionyl-tRNA formyltransferase, mitochondrial
- Trifunctional purine biosynthetic protein adenosine-3
- Folylpolyglutamate synthase
- Bifunctional purine biosynthesis protein ATIC
- 10-formyltetrahydrofolate dehydrogenase
- AT16211p
- Dihydropteridine reductase
Sequence:
MLRFNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTTKRTSDPTKQNAVVMGRKTYFGVPESKRPLPDRLNIVLSTTLQESDLPKGVLLCPNLETAMKILEEQNEVENIWIVGGSGVYEEAMASPRCHRLYITKIMQKFDCDTFFPAIPDSFREVAPDSDMPLGVQEENGIKFEYKILEKHS
Protein: Olfactory receptor (Q9QZ19)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MERSNKTTPVSSFILLGLSAHPKLEKTFFVLILLMYLVILLGNVVLILVSILDSHLHTPMYFFLGNLSFLDICYTTSSVPLILDSFLTPRKTISFSGCAVQMFLSFAMGATECVLLGMMAFDRYVAICNPLRYPVVMSKAAYVPMAAGSWVSGSITATVQISLAMTLPFCGDNVINHFTCEILAVLKLACADISINVISMAVANAMFLGVPVLFIFVSYIFILSTILRIPSAEGRKKAFSTCSAHLTVVLVFYGTILFMYGKPKSKDPLGADKQDLADKLISLFYGVVTPMLNPIIYSLRNKDVKAAVTNLVGQKHFKW
Protein: Skp1-related protein (G5ECU1)
Organism: Caenorhabditis elegans
Function: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination.
Interaction partners:
- Cullin-1
- Cullin-6
- RING-box protein 1
- F-box/WD repeat-containing protein sel-10
- F-box/WD repeat-containing protein lin-23
- F-box/SPRY domain-containing protein 1
- F-box domain-containing protein
- F-box protein dre-1
- F-box domain-containing protein
- F-box domain-containing protein
Sequence:
MADQKKVSEAAKEREIKISSSDNEIFLVPRNVIRLSNTINTLLMDLGLDDEEGTNAEPIPVQNVTASILKKVISWCNHHHSDPISTEDSDNREKRTDDIGSWDVEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKSPEEIRRTFNIKNDFTPEEEEQIRKENAWCED
Protein: Probable LRR receptor-like serine/threonine-protein kinase PAM74 (EC 2.7.11.1) (Protein PHOTOSYNTHESIS AFFECTED MUTANT 74) (C0LGW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for accurate photosynthesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1
Sequence:
MDSPCWLLLLLLGAFAIIGCVQAQDQQEFISLDCGLPMTEPSSYTESVTGLRFSSDAEFIQTGESGKIQASMENDYLKPYTRLRYFPEERRNCYSLSVDKNRKYLIRARFIYGNYDGRNSNPIFELHLGPNLWATIDLQKFVNGTMEEILHTPTSNSLNVCLVKTGTTTPLISALELRPLGNNSYLTDGSLNLFVRIYLNKTDGFLRYPDDIYDRRWHNYFMVDDWTQIFTTLEVTNDNNYEPPKKALAAAATPSNASAPLTISWPPDNPGDQYYLYSHFSEIQDLQTNDTREFDILWDGAVVEEGFIPPKLGVTTIHNLSPVTCKGENCIYQLIKTSRSTLPSLLNALEIYTVIQFPRSETNENDVVAVKNIEAAYKLSRIRWQGDPCVPQKYAWDGLNCSNNTDVSKPPRVLSLNLSSSGLTGIIAAAIQNLTHLEKLDLSNNTLTGVVPEFLAQMKSLVIINLSGNNLSGPLPQGLRREGLELLVQGNPRLCLSGSCTEKNSKKKFPVVIVASVASVAIIVAVLVIIFVLSKKKSSTVGALQPPLSMPMVHDNSPEPSIETKKRRFTYSEVIKMTNNFQRVVGEGGFGVVCHGTINGSEQVAVKVLSQSSSQGYKHFKAEVDLLLRVHHTNLVSLVGYCDERDHLALIYEFLPKGDLRQHLSGKSGGSFINWGNRLRIALEAALGLEYLHSGCTPPIVHRDIKTTNILLDEQLKAKLADFGLSRSFPIGGETHISTVVAGTPGYLDPEYYQTTRLGEKSDVYSFGIVLLEIITNQPVIDQSRSKSHISQWVGFELTRGDITKIMDPNLNGDYESRSVWRVLELAMSCANPSSVNRPNMSQVANELKECLVSENLRENMNMDSQNSLKVSMSFDTELFPRAR