wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear factor of activated T-cells, cytoplasmic 3 (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (A0A0G2JTY4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:30980393}. Nucleus {ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:30980393}. Note=The subcellular localization of NFATC plays a key role in the regulation of gene transcription (By similarity). Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals (By similarity). Cytoplasmic when phosphorylated and nuclear after activation, that is controlled by calcineurin-mediated dephosphorylation (By similarity). Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (By similarity). Translocates to the nucleus in the presence of EDN1 following colocalization with F-actin filaments, translocation is ROCK-dependent (PubMed:19538478). Translocates to the nucleus in response to lipopolysaccharide treatment of macrophages (By similarity). {ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:19538478}.
Interaction partners:
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 10
- Calcineurin subunit B type 1
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Mitogen-activated protein kinase 9
- Protein phosphatase 3 catalytic subunit alpha
- Transcription factor GATA-4
- Calcineurin subunit B type 2
- Serine/threonine-protein phosphatase
- Mitogen-activated protein kinase 3
Sequence:
MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ
Protein: PTS system mannose-specific EIIC component (EII-P-Man) (EIIC-Man) (Mannose permease IIC component) (P69801)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.
Subcellular location: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00429, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:31209249, ECO:0000269|PubMed:8774730}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00429, ECO:0000269|PubMed:31209249}.
Interaction partners:
- PTS system mannose-specific EIIAB component
- PTS system mannose-specific EIID component
- N-acetylgalactosamine permease IID component
- Phosphocarrier protein HPr
- Mannose-6-phosphate isomerase
- Phosphomannomutase
- N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1
- N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2
- Fructokinase
- PTS system glucose-specific EIICB component
Sequence:
MEITTLQIVLVFIVACIAGMGSILDEFQFHRPLIACTLVGIVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASIISTILVIAGHQSIGAGIALAIPLAAAGQVLTIIVRTITVAFQHAADKAADNGNLTAISWIHVSSLFLQAMRVAIPAVIVALSVGTSEVQNMLNAIPEVVTNGLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGTVMAVLYIQLSPKYNRVAGAPAQAAGNNDLDNELD
Protein: PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) (Q96BD5)
Organism: Homo sapiens (Human)
Function: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- REST corepressor 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- Histone deacetylase 1
- Histone deacetylase 2
- Zinc finger protein 217
- DNA excision repair protein ERCC-1
- DNA polymerase delta catalytic subunit
- C-terminal-binding protein 1
- High mobility group protein 20A
Sequence:
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEATVGAISNGPDCTPPANAATSTPAPSPSSQSCTANCNQGEETK
Protein: Nebulosa, isoform A (Nebulosa, isoform C) (Q8IQH6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MVHTSTSNNSQKWPQYVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGILPLIFGAIFFFMPESPTYLVSKDRSENAIKSIQWLRGKEYDYEPELAELRETDRETKANKVNVWAALNRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQELAGNRSTPQAIPAEK
Protein: DNA repair protein RAD10 (P06838)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD1 forms an endonuclease that specifically degrades single-stranded DNA.
Subcellular location: Nucleus.
Interaction partners:
- DNA repair protein RAD14
- DNA repair protein RAD1
- DNA repair protein RAD2
- DNA repair protein RAD4
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- DNA mismatch repair protein MSH2
- Crossover junction endonuclease MUS81
- DNA repair protein RAD7
- DNA repair protein RAD16
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
Sequence:
MNNTDPTSFESILAGVAKLRKEKSGADTTGSQSLEIDASKLQQQEPQTSRRINSNQVINAFNQQKPEEWTDSKATDDYNRKRPFRSTRPGKTVLVNTTQKENPLLNHLKSTNWRYVSSTGINMIYYDYLVRGRSVLFLTLTYHKLYVDYISRRMQPLSRNENNILIFIVDDNNSEDTLNDITKLCMFNGFTLLLAFNFEQAAKYIEYLNL
Protein: Proteasome subunit alpha type-3 (Macropain subunit Y13) (Multicatalytic endopeptidase complex subunit Y13) (Proteasome component Y13) (Proteinase YSCE subunit 13) (P23638)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- 26S proteasome regulatory subunit RPN3
- Proteasome subunit beta type-4
- Proteasome maturation factor UMP1
- Ubiquitin carboxyl-terminal hydrolase 6
- 26S proteasome regulatory subunit RPN5
- 26S proteasome subunit RPT4
- Proteasome subunit alpha type-4
- 26S proteasome regulatory subunit RPN8
- 26S proteasome regulatory subunit RPN10
- 26S proteasome regulatory subunit RPN1
Sequence:
MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK
Protein: UDP-glycosyltransferase 1 (BvUGT1) (EC 2.4.1.368) (Oleanolate 3-O-glucosyltransferase UGT1) (K4GHR9)
Organism: Barbarea vulgaris (Yellow rocket) (Erysimum barbarea)
Function: Catalyzes the transfer of a glucose (Glc) moiety from UDP-Glc to the C-3 position of the oleanane sapogenins oleanolate and hederagenin. The monoglucosylated hederagenin 3-O-beta-D-glucoside is a feeding deterrent of the yellow-striped flea beetle (Phyllotreta nemorum).
Interaction partners:
Sequence:
MVSEITHKSYPLHFVLFPFMAQGHMIPMVDIARLLAQRGVKITIVTTPHNAARFENVLSRAIESGLPISIVQVKLPSQEAGLPEGNETFDSLVSMELLVPFFKAVNMLEEPVQKLFEEMSPQPSCIISDFCLPYTSKIAKKFNIPKILFHGMCCFCLLCMHVLRKNREILENLKSDKEHFVVPYFPDRVEFTRPQVPMATYVPGEWHEIKEDIVEADKTSYGVIVNTYQELEPAYANDYKEARSGKAWTIGPVSLCNKVGADKAERGNKADIDQDECLKWLDSKEEGSVLYVCLGSICSLPLSQLKELGLGLEESQRPFIWVVRGWEKNKELLEWFSDSGFEERVKDRGLLIKGWSPQMLILAHHSVGGFLTHCGWNSTLEGITSGIPLLTWPLFGDQFCNQKLVVQVLKVGVSAGVEEVTNWGEEEKIGVLVDKEGVKKAVEELMGESDDAKERRKRVKELGQLAQKAVEEGGSSHSNITSLLEDIMQLAQSNN
Protein: Protein SIEVE ELEMENT OCCLUSION A (AtSEOa) (Protein SIEVE ELEMENT OCCLUSION-RELATED 2) (AtSEOR2) (Q93XX2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Scaffold protein required to form the phloem filament matrix in sieve elements.
Interaction partners:
- Expressed protein
- Protein PHLOEM PROTEIN 2-LIKE A1
- Protein RESTRICTED TEV MOVEMENT 2
- RNA-binding KH domain-containing protein PEPPER
- SUPPRESSOR OF ABI3-5
- Protein RESTRICTED TEV MOVEMENT 1
Sequence:
MAQRFQLNSQTLPTADPLKRVSLIPRSAEQRLADNAGERRPLAPRSHEDNPFGGHTDDHHVAAPADHNKVMDHNSENLGSIVPKTAHYPHPSEEILDANIRHSMVPKSLGPNSLGGRFGPGKKQAFHRNGRPMFSLSDDRVMADRVLKTHSPDMIFFDVTSLLSVVNDIFKSHVPSIDSSAPKPSLVFKDYADHTSFETFADLIDQISCEIDCKCLHGGESHGMMTSGLHLDSRNTTTFSVLSLVSKYRWDAKLVLVLSALAVKYGVFLLLAETHATNQLTKSLALIKQLPSIFSRQNALHQRLDKTRILMQDMVDLTTTIIDIYQLPPNHITAAFTDHIPTAVYWIVRCVLICVSHISGASGFKQDQIMSFMEVSEIHENSERLRKINAYLLEQFKKSKMTIEEGIIEEEYQELIQTFTTIIHVDVVPPLLRLLRPIDFLYHGAGVSKRRVGINVLTQKHVLLLISDLENIEKELYILESLYTEAWQQSFEILWVPVQDFWTEADDAKFEALHMNMRWYVLGEPRKLRRAAIRFVREWWGFKNRPILVALDPKGQVMSTNAFPMVWIWQPFAHPFTTARERDLWSEQEWNLEFLIDGTDPHSLNQLVDGKYICLYGGEDMQWIKNFTSLWRNVAKAANIQLEMVYVGKRNPKNGIQPIINTIREENLSHTLPDLFQIWFFWTRVESMWESKQRMLKAHGIKGREGFKEEEKDLVLQEVVAMLGYGGEGDGWGLVSKASDMMVRAKGNLFSRGLAEFNEWEVNIPTKGFLTALNDHLLMRLPPHHCTRFMLPETAGIIPNEVECTECRRTMEKYYLYQCCLE
Protein: Staphylocoagulase (Q4W8J9)
Organism: Staphylococcus aureus
Interaction partners:
Sequence:
MKKQIISLGALAVASSLFTWDNKADAIVTKDYSKESRVNENSKYDSPISDWYLSSVLNRLGDQIYYAKELTNKYEYGEKEYKKAIDKLMTRVLGEDQYLLEKKKAQYEVYKKWFEKHKSENPNSDLKMTKFHDFDIYRLSMKEYNEIHQSIKEAVDDFNSEVKEIQYKEKDLVPYNEETEKRVTNGIYDFVCEIDTLYAAYFNHNQYGHNAKELRAKLDIILGDVKDPIRITNERIRKEMMDDLNSIIDDFFMDTNMNRPLNISKYNPDIHDYTNKPENRANFDKLVKETREAVDKADDSWKTKTVKKYGETVTKSPVVKEEKKVEDPQSPKFDNQQEVKTTAGKAEETTQPVAQPLVKIPQGTITGEIVKGPDYLTMENKTLQGEIVQGPDFPTMEHNRPSLSNNYTHPPLANPILKGIEGSSSKLEIKPQGTESTLKGIQGESSDIEVKPQATETTEASQYGPRPQFNKTPKYVKYRDAGTGIREYNDGTFRYEARPRFNKPSETNAYNVTTNQDGTVSYGARPTQNKPSETNAYNVTTHGNGQVSYGARPTYKKPSKTNAYNVTTHANGQVSYGARPTHNKPSETNAYNVTTHGNGQVSYGARPTHNKPSETNAYNVTTHANGQVSYGARPTHNKPSKTNAYNVTTHADGTATYGPRVTK
Protein: RNA-binding KH domain-containing protein (A0A1P8BC43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Organelle RRM domain-containing protein 2
Sequence:
MVERGKRTHNRFRDNNNDNNRNQRRRLSYESEEKKIDNKDDLVVVYRILCPSGVMGSVIGKSGKVINLIRQETRARIKVVDPFPGCSERVITIFCSVSEKKDIVDIEYSELDYSVPLCSAQAALLKVHDAIVASLATAAENTKIDRDDFRECRLLVPSSQCSIVIGKSGSIIKNIRGRTRANVKVVSKDVSDPSHTCAMDFDNIVMISGETESVKKALFAVSAIMYKVSPREQIPLDTTVQEVPASIIIPSDLSIYPQAGLYPSQDSIFQHGANVSSFIGTLPQGYGENAANPVPVFSASALPVVHGFGGSSRSEKLAIKVICSSSKIGRVIGKGGLTIKGIRQASGSHIEVNDSRTNHDDDCVITVTATESPDDLKSMAVEAVLLLQEKINDEDEDKVKMQLLVSSKVIGCIIGKSGSIISEIRKRTKADIHISKGNNTPKCADPNDELVEISGEVSNVRDALIQIVLRLRDDVLRDRETGSRNQPPARSENNNFFSSSSSNTGLALPQSFMSSVPQVASVDFNRRPETGSSMSMLPSSGGIYGYGSFPVGNTSYGSNSSYSSNLYGGLPQSTTMEVRIPANAVGKVMGRGGGNLDNIRRVCLIFIFIFPSSLLSDCHSFIRLFFPLSYITFSHGMCPLSLSLSQISGAMIEISDSKNSHGGRVALISGTSEQKRTAENLFQAFIMST
Protein: UBX domain-containing protein 1 (Q9TXH9)
Organism: Caenorhabditis elegans
Function: Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:20977550}. Note=Colocalizes with cdc-48.1 to the perinuclear region in spermatocytes. {ECO:0000269|PubMed:20977550}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase homolog 1
- Transitional endoplasmic reticulum ATPase homolog 2
- UBX domain-containing protein 6
- UBX domain-containing protein 2
- ATPase family protein 2 homolog
- UBX domain-containing protein 4
- Derlin-1
- Uncharacterized protein ZK688.5
- UBX domain-containing protein 3
- E3 ubiquitin-protein ligase hrd-like protein 1
Sequence:
MSIAQQLMDMGFPADKAEAAAGNNRNLDQALDWIEKDGAGVPMETDAPAQAAPGAADSGAPPVAASFKCDDCGKLLANDDAIMFHASKTKHENFSESSEAIKPLTAEEKAAKVLEIREKIKVHQAKKAKLEAEENREKEKKRREDGKAMISHKEAARDREIREAAQDRRREKNEDEIARKRVLEQIRLDKEARKAKASGQPVPEAKPAPSAAPVAPPKDYSTTTLQFRLLDGQTVRQQFEANEPLAMVRAWVETNHANGVPFTLMTPFPRKVFTEDDMGTPLKVLNLVPSANVILNRAA
Protein: Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) (Q9P289)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase that acts as a mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:27807006}. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000269|PubMed:27807006}.
Interaction partners:
- Serine/threonine-protein kinase 25
- Striatin-interacting protein 1
- Programmed cell death protein 10
- MOB-like protein phocein
- Striatin-3
- Serine/threonine-protein kinase 24
- CTTNBP2 N-terminal-like protein
- Cortactin-binding protein 2
- TRAF3-interacting JNK-activating modulator
- Calcium-binding protein 39
Sequence:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Protein: Kinesin-like protein (D3ZIA5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Centromere-associated protein E
- Kinesin-like protein KIF11
- Kinetochore protein Nuf2
- Kinesin-like protein KIF2C
- Kinesin-like protein
- Dual specificity protein kinase TTK
- DLG associated protein 5
- Protein regulator of cytokinesis 1
- Mitotic spindle assembly checkpoint protein MAD2A
- Kinesin-like protein KIF14
Sequence:
MKWIAEEAGLGLNLWLCLERLEANSAKLSRSLLVFAYGATGSGKTHTMLGSTAEPGVMYLTMLDLFKCMDEVKDEKECSTAVSYLEVYNEQIRDLLTNSGPLAVREDAQKGVVVQGLTLHQPKSSEEILQLLDNGNKNRTQHPTDMNAASSRSHAVFQIYLRQQDKTASINQNVHIAKMSLIDLAGSERASISGTKGTRFVEGTNINKSLLALGNVINALADTKRRNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKDIKSSQLKSNVVNLSSHISQYVKICNMQKAEILMLKEKLKAYEGQKALTDRNDCAKLVHSNVEDKEIERFQEILNCLFQNREGMRQEYLKVEMLLKENELKSSYHQQCHKQIEMMCSEDKLEKATCRRDHRLEKLKSNRCVLEKKKEEMLKQFDENTNWLHRVESEMRLLGQNGDIPEGLNKDLHCHHLHLQNKDLKTQMGHMMTLAALQEQQHGQTEAVLNALLPVLRKQYWRLKETGLSNAAFDSDFKDIEHLVERKKVVAWADQTAEHSNQSDVPGTSLLMTFPQLGPIQSIPCCSSMSDPSILKITPQRRTKRKLIPSPLKVKHTQKSALSERTQLNDSFSKELQPIVYTPEDSRRTVQDLSPPLARASSHSANGMNDNSLKALCRTESPLSRTECKEGLYSTSAICDGIKSLKNNLPEPLPSSKSTLHRVESSSFPTKDSRSVSTSVPSYMAMTTAAKRKWKFMSSTSDASLKSDESCGLAKRIRQDNSSVKLIRENRLRVGYKKTTNKTNSNMLRKFRRNTSKENVQ
Protein: RE14786p (Rab30, isoform A) (Rab30, isoform B) (Rab30, isoform C) (Rab30, isoform D) (Q9VM50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Conserved oligomeric Golgi complex subunit 4
- GRIP and coiled-coil domain containing 88 kDa
- Centrosomin's beautiful sister, isoform A
- Rab proteins geranylgeranyltransferase component A
- FI04457p
- GH16847p
- Golgin-245
- Conserved oligomeric Golgi complex subunit 6
- GH11193p
- Protein bicaudal D
Sequence:
MEDYKFLFKIVLVGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEVEGEKIKLQIWDTAGQERFRSITQSYYRSAHALILVYDISCQPTFDCLPDWLREIQEYANSKVLKILVGNKTDRDDREIPTQIGEEFAKQHDMYFLETSAKEAENVERLFYEIAAELIGQARSKDGSSSAAAAAAQRQSEGSSIGLGSFSAKAAQSNCCGGLASGGSNSSQGG
Protein: Protein RGF1 INDUCIBLE TRANSCRIPTION FACTOR 1 (Q1G3Q4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that plays a central role in mediating RGF1 hormone peptide signaling leading to the production of reactive oxygen species (ROS) in roots to modulate meristem size and root growth, probably via oxidative post-translational modification of the transcription factor PLETHORA (e.g. PLT1 and PLT2).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein GOLVEN 11
- Transcription factor bHLH148
- LRR receptor-like serine/threonine-protein kinase RGI3
Sequence:
MGIQKPAWLDALYAEKFFVGCPYHETAKKNERNVCCLDCCTSLCPHCVPSHRFHRLLQVRRYVYHDVVRLEDLQKLIDCSNVQAYTINSAKVVFIKKRPQNRQFKGAGNYCTSCDRSLQEPYIHCSLGCKVDFVMKRYRDITPFLKPCHTLTLGPDYIIPQDLLTDDEVAAYETPRSTVVDGDESMSWSSASSDNNNAGAAAAYAATTTHVVRKKRTGFCLCAKSANSYKEVSEDPDDISACINRRKGVPQRSPLC
Protein: Inner kinetochore subunit fta1 (CENP-L homolog) (Constitutive centromere-associated network protein fta1) (Sim4 complex subunit fta1) (Sim4-mal2-associated protein 1) (O36024)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:16079914}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16079914}.
Interaction partners:
- Inner kinetochore subunit mal2
- Inner kinetochore subunit fta3
- Inner kinetochore subunit fta7
- Inner kinetochore subunit fta6
- Inner kinetochore subunit fta4
- Inner kinetochore subunit mis15
- Inner kinetochore subunit fta2
- Inner kinetochore subunit mis6
- Inner kinetochore subunit mis17
- Inner kinetochore subunit cnl2
Sequence:
MTLRDHHFYNVTYTAYRLSPLFGFEYSNLTEIGKKLTRFLRYGTDRTGYFTNSTRFADLIIEKATFTEFGNTSSFPKFLKLDISYETSSDLEVKRKGQMFFFESFRKFSHAEADRTRLSLEGNSVFFSLALVRMDGALWMAVEQFLQQEFDTQILPCLIAPEILLEFLKIWQNHVNSQTALPLELTWTTGNPNLSSVTISIRPEDLKKIFRSSSFFYPILMEHIKRCTSLDLTNSVFSLSKVNTDCAILTSSGKLKIFSKAQNIVFDVLLALEPMQLPEY
Protein: DNA-binding protein Ewg (Protein erect wing) (Q24312)
Organism: Drosophila melanogaster (Fruit fly)
Function: May function as a positive regulator of transcription in developing and differentiated neurons, regulating common aspects of neuronal differentiation and maintenance. Requirement in the CNS may be higher than in the peripheral system. Vital for development of the indirect flight muscles.
Subcellular location: Nucleus {ECO:0000269|PubMed:8388540}. Note=Not in nucleolus.
Interaction partners:
- Mitochondrial transcription factor A, isoform B
- FI18188p1
- Protein elav
- NAD-dependent histone deacetylase sirtuin-1
- Earthbound 1
- NAD-dependent protein deacetylase Sirt7
Sequence:
MATTSYRLVVAPAGSQRSSTGNVVVTTTSSGSHSSNGANGGTGGTSAGSSTLGSGLNVTTITATSGGQLQSAGNTSQSNGTTYKIEMLEEDIQSLGSDDDDEDLISSDGSLYEGDLGSMPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPTIHTVTTMTPPTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAQNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVSAAQAHAHSQSQAHSQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQGYPVSVSNVISVPVSMYQSVMANVQQIQTNSDGTVCLAPMQVENGDQLETITMSPGMHQMMIQGGPGQEPQLVQVVSLKDATLLSKAMEAINSGNVKSEDTIIMEQ
Protein: Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1) (Q9JHJ3)
Organism: Mus musculus (Mouse)
Function: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:19489740, ECO:0000269|PubMed:31661432}; Single-pass type I membrane protein {ECO:0000255}; Lumenal side {ECO:0000305}.
Interaction partners:
- Lysosomal dipeptide transporter MFSD1
Sequence:
MFRCWGPHWGWVPCAPTPWLLLSLLVCSAPFGLQGEETRQVSMEVISGWPNPQNLLHIRAVGSNSTLHYVWSSLGPPAVVLVATNTTQSVLSVNWSLLLSPDPAGALMVLPKSSIQFSSALVFTRLLEFDSTNASEGAQPPGKPYPPYSLAKFSWNNITNSLDLANLSADFQGRPVDDPTGAFANGSLTFKVQAFSRSGRPAQPPRLLHTADVCQLEVALVGASPRGNHSLFGLEVATLGQGPDCPSVNERNSIDDEYAPAVFQLNQLLWGSSPSGFMQWRPVAFSEEERARESALPCQASTLHSTLASSLPHSPIVQAFFGSQNNFCAFNLTFGAPTGPGYWDQYYLCWSMLLGMGFPPVDIFSPLVLGIMAVALGAPGLMFLGGGLFLLLRHRRYSEYQSIN
Protein: DNAation factor-related protein 2, isoform A (DNAation factor-related protein 2, isoform C) (LD32009p) (Q7K304)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAREESRGKRPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPASEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYPTGVDVIKAAISAIPKIVCETIHALELHDETPSWKIMDNKGRVTVVLHWDQRQGGGSGGGGGGGGAGGGVGSMCSGLGSSNGLLSSDKYSPSKKGLSAQSSLDNKSVSSQSSQPRYASPQITVISDDGPASIYHPGGVVLPPGVVIPGGSRRLSKQGSSFDSTVGVGVGAVHVHTPECAHHAHTPSRAGSPSTTECDFHCCALHEEGRKIAVHKSVATSPIQDGSSSPQPQSAPSVMDPMLGGSGGGGSGSMQRRSSGAKGHVRFLDIAPERDSSESETENTVMEDDKTTTEKFLLLIDQLSVDQKRHLSIKDIGIILERLNSKILDVERLDRESESDDCYNWTIKATIRGDALRELGVIYNGNYYAISEHPGYKEELEENGEEVEEEEEEDEEDRI
Protein: Regulator of G protein signaling 6 (A0A0A0MRA9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS