wanglab/gogpt-training-data huggingface dataset:
Protein: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (EC 2.-.-.-) (Thiamine biosynthesis protein 5) (Thiamine pyrimidine synthase) (P43534)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
Interaction partners:
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21
- Thiamine thiazole synthase
- Thiamine biosynthetic bifunctional enzyme
- Probable pyridoxal 5'-phosphate synthase subunit SNZ2
- Probable pyridoxal 5'-phosphate synthase subunit SNO2
- Probable pyridoxal 5'-phosphate synthase subunit SNO3
- Putative pyridoxal kinase BUD16
- Probable pyridoxal 5'-phosphate synthase subunit SNZ3
- Pyridoxamine 5'-phosphate oxidase
Sequence:
MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDMAILEPTNPSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITEDFQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGKIDAGIGIECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVRKFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQYQRCYAYFSSSLYNVHRDWKKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFKRLALPA
Protein: GATA transcription factor 5 (Q9FH57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- LOB domain-containing protein 15
- LOB domain-containing protein 30
- NAC domain-containing protein 75
- Glutamyl-tRNA
Sequence:
MEQAALKSSVRKEMALKTTSPVYEEFLAVTTAQNGFSVDDFSVDDLLDLSNDDVFADEETDLKAQHEMVRVSSEEPNDDGDALRRSSDFSGCDDFGSLPTSELSLPADDLANLEWLSHFVEDSFTEYSGPNLTGTPTEKPAWLTGDRKHPVTAVTEETCFKSPVPAKARSKRNRNGLKVWSLGSSSSSGPSSSGSTSSSSSGPSSPWFSGAELLEPVVTSERPPFPKKHKKRSAESVFSGELQQLQPQRKCSHCGVQKTPQWRAGPMGAKTLCNACGVRYKSGRLLPEYRPACSPTFSSELHSNHHRKVIEMRRKKEPTSDNETGLNQLVQSPQAVPSF
Protein: Knob associated heat shock protein 40 (O96123)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock 70 kDa protein
- Heat shock 70 kDa protein
- Endoplasmic reticulum chaperone GRP170
- Heat shock protein 110
- Endoplasmic reticulum chaperone BIP
- Heat shock protein 70
- HSP40, subfamily A
- Heat shock protein 90
- Heat shock protein 90, putative
- Endoplasmin, putative
Sequence:
MAIFKKYRFRENKIIFLFFIKIFLFSLFIWELCCFNKEKFQDQIQTSYYNKNNTSGNVSNLIIKRNLAQTQRNFKSKNGKASTKKNEDYYSILGVSRDCTNEDIKKAYKKLAMKWHPDKHLNAASKKEADNMFKSISEAYEVLSDEEKRDIYDKYGEEGLDKYGSNNGHSKGFKRTDPNDVFSKFFKTETKFYSNSPSSPNGNVLFEGSLFGGSSPFSGINPRSGSGYTTSKSFSSMDKVEEYVVPLYVTLEDLYNGTQKKLKVTRKRCQGVTTYDDEFFVTVDIKSGWCDGTTITYKGEGDQTSPMSNPGDLVFTIKTVDHDRFVRSYNDLIYRCPITLEQALTGHKFTIITLDNRDIDIQVDEIVTPLTTRVITSEGMPYMENPKMKGNLIIEFDIIFPKKLSDEQKELIKEALGGNGF
Protein: Cell wall / vacuolar inhibitor of fructosidase 1 (AtC/VIF1) (F4HWQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibits fructosidases from vacuoles (vacuolar invertase VI).
Subcellular location: Vacuole {ECO:0000305}.
Interaction partners:
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- At5g62340
- Pectin methylesterase inhibitor 1
- At1g31750
- Protein SPIRAL1-like 1
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- non-specific serine/threonine protein kinase
- Histone deacetylase complex subunit
- Pectinesterase inhibitor 7
Sequence:
MKMMKVMMLIVMMMMVMVMVSEGSIIEPTCKETPDFNLCVSLLNSDPRGSSADTSGLALILIDKIKGLATKTLNEINGLYKKRPELKRALDECSRRYKTILNADVPEAIEAISKGVPKFGEDGVIDAGVEASVCQGGFNGSSPLTSLTKSMQKISNVTRAIFYSNSIVKEEACGSSWPSLALNIDSKACVVSLQNIQFNRGRTCW
Protein: V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar H ATPase protein 13) (Vacuolar proton pump subunit alpha) (Q9XW92)
Organism: Caenorhabditis elegans
Function: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates. Lysosomal acidification also leads to changes in mitochondrial morphology and function. Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity. In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance. Involved in receptor-mediated endocytosis.
Interaction partners:
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit
- Probable V-type proton ATPase subunit F
- V-type proton ATPase subunit B 2
- Probable V-type proton ATPase subunit G
- V-type proton ATPase subunit D
- V-type proton ATPase subunit E
- Probable V-type proton ATPase subunit H 2
- V-type proton ATPase subunit C
- V-type proton ATPase subunit B 1
Sequence:
MAAESSYGFVYGVSGPVVTAEKMAGSAMYELVRVGHQELVGEIIRLEGDYATIQVYEETSGVTIGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDIADITQSIYIPKGVSTNALSREARWDFVVSKDLRVGGHVTGGDIIGTVDENLLIKHKILLPPSACGTITFVAPSGQYTVEDTLLELEFAGRKQKFSMLQIWPVRSPRPVTEKLAANNPLLCGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDAIIYVGCGERGNEMSEVLRDFPELTMEVEGVTTSIMKRTALVANTSNMPVAAREASIYTGITLAEYFRDMGLNVAMMADSTSRWAEALREISGRLGEMPADSGYPAYLAARLASFYERAGRVKCLGSPEREGSVTIVGAVSPPGGDFADPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSEYMRALEEFYEKNYPEFVSLRTKCKEILQEEEDLSEIVQLVGKASLAESDKVTLEVAKIIKDDFLQQNGYTKYDRFCPFYKTVGMLKNMIGFYDLARHAVEATAQSDNKITWNVIKDSMGDLIYQLSAMKFKDPVADGEAKIRKDYEDLAEAMANAFRNLED
Protein: Probable proteasome subunit alpha type-1 (O94517)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable proteasome subunit alpha type-2
- Probable proteasome subunit beta type-6
- Probable proteasome subunit alpha type-4
- Probable proteasome subunit beta type-5
- Probable proteasome subunit alpha type-7
- Probable proteasome subunit alpha type-6
- Probable proteasome subunit beta type-1
- Probable proteasome subunit beta type-2
- Probable proteasome subunit beta type-4
- Probable proteasome subunit beta type-7
Sequence:
MSQARGFDRTITVFSPEGRLYQVEYAFKAFNNAGITSVGVTGKNCACVISQKKVPDKLIDASTVKHVFPITKGIGCVMTGSIADARAQVSRARSEAAEFEYKNGYPMPCDVLAKRMANIAQVSTQRAAMRPLGVAMTLVAVDDEIGPSLFKLDPAGFYIGYKATSAGPKQTETINWLEKRFKKDGIPSNLTDTVETGIQALMSSLSTDFKSTELQIGVVEDDKPFRVLSVEEIEAHLQSIAEKD
Protein: 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) (Q9UGI9)
Organism: Homo sapiens (Human)
Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Interaction partners:
- 5'-AMP-activated protein kinase subunit beta-1
- 5'-AMP-activated protein kinase subunit beta-2
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- Serine/threonine-protein kinase STK11
- Calcium/calmodulin-dependent protein kinase kinase 2
- 5'-AMP-activated protein kinase subunit gamma-1
- 5'-AMP-activated protein kinase subunit gamma-2
- Glycogen [starch] synthase, muscle
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Sequence:
MEPGLEHALRRTPSWSSLGGSEHQEMSFLEQENSSSWPSPAVTSSSERIRGKRRAKALRWTRQKSVEEGEPPGQGEGPRSRPAAESTGLEATFPKTTPLAQADPAGVGTPPTGWDCLPSDCTASAAGSSTDDVELATEFPATEAWECELEGLLEERPALCLSPQAPFPKLGWDDELRKPGAQIYMRFMQEHTCYDAMATSSKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQIYEIEQHKIETWREIYLQGCFKPLVSISPNDSLFEAVYTLIKNRIHRLPVLDPVSGNVLHILTHKRLLKFLHIFGSLLPRPSFLYRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNECGQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALGA
Protein: Beta-tropomyosin (Tropomyosin 2) (Q05705)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAGISSIDAVKKKIQSLQQVADEAEERAEHLQREADAERQARERAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEEADRKYEEVARKLVVLEGELERSEERAEVAESRVRQLEEELRTMDQSLKSLIASEEEYSTKEDKYEEEIKLLGEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
Protein: Response regulator SaeR (Q5HR28)
Organism: Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A)
Function: Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Histidine protein kinase SaeS
- Heme sensor protein HssS
- Sensor protein SrrB
- Signal transduction histidine-protein kinase ArlS
- Sensor protein kinase WalK
- Sensor histidine kinase GraS
- histidine kinase
- DoxX family protein
- Sensor protein kinase WalK
- Response regulator protein VraR
Sequence:
MTHLLIVDDEKDIVDICQTYFEYEGYQVTTTTCGKEALKLLSSDIDIMILDIMMPEVSGYDIVKKMKDMQLDIPFIYLTAKTQEHDTIYALTLGADDYIKKPFSPRELVLRTNNLLARMSKSNHSNKIEQLEFDGLVLKNLSKTLTINNIEIPMRIKEFELLWYLASREGEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKHDFLPYTITTVWGLGYKFERSR
Protein: Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) (Q9H6R4)
Organism: Homo sapiens (Human)
Function: Probably associated with rRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}. Chromosome {ECO:0000250|UniProtKB:Q8R5K4}. Note=Localizes to condensed chromosomes in mitosis. {ECO:0000250|UniProtKB:Q8R5K4}.
Interaction partners:
- Nucleolar protein 58
- WD repeat-containing protein 46
- Bystin
- U3 small nucleolar RNA-associated protein 6 homolog
- WD repeat-containing protein 75
- U3 small nucleolar RNA-associated protein 4 homolog
- HEAT repeat-containing protein 1
- Nucleolar protein 10
- WD repeat-containing protein 43
- U3 small nucleolar ribonucleoprotein protein MPP10
Sequence:
MGPAPAGEQLRGATGEPEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRIDAFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPMIRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLRLERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPAASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILEDFAVLGEGLVQTVEARSERWTV
Protein: Protein SUPPRESSOR OF MAX2 1 (AtSMXL1) (Q9FHH2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of a transcriptional corepressor complex that acts downstream of MAX2 to negatively regulate karrikins/strigolactone responses. Probable target of MAX2 during germination and seedling photomorphogenesis. Acts probably specifically in the karrikin pathway.
Interaction partners:
- F-box protein MAX2
- Probable esterase KAI2
- Strigolactone esterase D14
- F-box/kelch-repeat protein SKIP25
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Carotenoid cleavage dioxygenase 7, chloroplastic
- Cytochrome P450 711A1
- Protein RADIALIS-like 2
- Protein RADIALIS-like 5
Sequence:
MRAGLSTIQQTLTPEAATVLNQSIAEAARRNHGQTTPLHVAATLLASPAGFLRRACIRSHPNSSHPLQCRALELCFSVALERLPTATTTPGNDPPISNALMAALKRAQAHQRRGCPEQQQQPLLAVKVELEQLIISILDDPSVSRVMREASFSSPAVKATIEQSLNNSVTPTPIPSVSSVGLNFRPGGGGPMTRNSYLNPRLQQNASSVQSGVSKNDDVERVMDILGRAKKKNPVLVGDSEPGRVIREILKKIEVGEVGNLAVKNSKVVSLEEISSDKALRIKELDGLLQTRLKNSDPIGGGGVILDLGDLKWLVEQPSSTQPPATVAVEIGRTAVVELRRLLEKFEGRLWFIGTATCETYLRCQVYHPSVETDWDLQAVSVAAKAPASGVFPRLANNLESFTPLKSFVPANRTLKCCPQCLQSYERELAEIDSVSSPEVKSEVAQPKQLPQWLLKAKPVDRLPQAKIEEVQKKWNDACVRLHPSFHNKNERIVPIPVPITLTTSPYSPNMLLRQPLQPKLQPNRELRERVHLKPMSPLVAEQAKKKSPPGSPVQTDLVLGRAEDSEKAGDVQVRDFLGCISSESVQNNNNISVLQKENLGNSLDIDLFKKLLKGMTEKVWWQNDAAAAVAATVSQCKLGNGKRRGVLSKGDVWLLFSGPDRVGKRKMVSALSSLVYGTNPIMIQLGSRQDAGDGNSSFRGKTALDKIAETVKRSPFSVILLEDIDEADMLVRGSIKQAMDRGRIRDSHGREISLGNVIFVMTASWHFAGTKTSFLDNEAKLRDLASESWRLRLCMREKFGKRRASWLCSDEERLTKPKKEHGSGLSFDLNQAADTDDGSHNTSDLTTDNDQDEQGFSGKLSLQCVPFAFHDMVSRVDDAVAFRAVDFAAVRRRITETLSERFETIIGESLSVEVEEEALQRILSGVWLGQTELEEWIEKAIVPVLSQLKARVSSSGTYGDCTVARLELDEDSGERNAGDLLPTTITLAV
Protein: Protein MRG2 (MRG family protein 2) (Morf Related Gene 2) (Q4V3E2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chromatin remodeling factor. Acts as a 'reader' protein by binding to H3K4me3 and H3K36me3 to control histone H4 acetylation. Increases the transcriptional levels of the flowering time genes FLC and FT. Binds the chromatin at the FT promoter upon interaction with CO.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histone acetyltransferase of the MYST family 1
- Histone acetyltransferase of the MYST family 2
- Histone acetyltransferase subunit NuA4-domain protein
- SWR1-complex protein 4
- Actin-related protein 4
- Homeobox protein HAT3.1
- SWR1 complex subunit 2
- Pathogenesis-related homeodomain protein
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
Sequence:
MGSPNAAAETDLTTDDFIGDTRRDSGSDTETNTDCDGEDLPLLLLPAPPGHFEEGERVLAKHSDCFYEAKVLKVEFKDNEWKYFVHYIGWNKSWDEWIRLDCLLKHSDENIEKQKEQGLKQQGIKSAMAWKVSKMKPRSPNVARGRKRKQDSVDTEKNVLPSDNLLSFNIPPALRKQLLDDFEFVTQMQKLVQLPRSPNVDGILKKYIDSQMKKHGRVTDSLEEILKGLRCYFDKALPVMLLYNNERKQYEESVSGGVSPSTVYGAEHLLRLFVKLPELLVHVNMAEETLKELQDNFVDILRFLRKNQSVLFVSTYKAVEEMEKKEG
Protein: DASH complex subunit dad2 (High osmolarity sensitivity protein 2) (Outer kinetochore protein dad2) (Q9UTG8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress.
Subcellular location: Nucleus {ECO:0000269|PubMed:16079914, ECO:0000269|PubMed:17352737, ECO:0000269|PubMed:20624975}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16079914, ECO:0000269|PubMed:17352737, ECO:0000269|PubMed:20624975}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16079914, ECO:0000269|PubMed:17352737, ECO:0000269|PubMed:20624975}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:20624975}. Note=Associates with the mitotic spindle and the kinetochore (PubMed:16079914). Kinetochore association occurs only during mitosis (PubMed:16079914). In the cytoskeleton, localizes to cortical microtubules (Probable). {ECO:0000269|PubMed:16079914, ECO:0000305|PubMed:20624975}.
Interaction partners:
- DASH complex subunit spc19
- DASH complex subunit dad3
- DASH complex subunit dad4
- DASH complex subunit dam1
- DASH complex subunit ask1
- DASH complex subunit dad1
- DASH complex subunit duo1
- DASH complex subunit spc34
- DASH complex subunit DAD5
- Kinetochore protein ndc80
Sequence:
MLQARIEEKQKEYELICKLRDSSNDMVQQIETLAAKLETLTDGSEAVATVLNNWPSIFESIQIASQHSGALVRIPPSTSNTNASATEQGDVEEV
Protein: Archaeosine synthase (EC 2.6.1.97) (Glutamine:preQ0-tRNA amidinotransferase) (Q58428)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group. Can use either glutamine, asparagine or ammonium as amino donor.
Interaction partners:
- Uncharacterized protein MJ1021
- tRNA-guanine
- Uncharacterized protein MJ0550
Sequence:
MLEPIAYDIGRLCKEEDKELTPKLIDIDVIGLSQEKIFYGIMTPFRCPNSKSIYELRKSYVKADGIKMPFDTFRELTSIFKKSFIGTVKYKGNVFKYQILNFGKHVDLIELEDADLYIIADGRRLIERKELQIIPKIREKISPNSAIYSPAVFPWEIPLLAYIGVDYFDDSLAKLYASMGYKFTKNRAVKVDSFSFEELYNNNKKVYEEILEEVRIAIKNGFLRNVVEETAVSHPYLWANYRRYEPDLRNIPLSKENKIIVTTNINIPEVKKYLERLDNYEPYSNIIVLLPCSSKKPYSISQSHQKFIKAIKSAKVVVEEVILTSPYGLVPRALERLVNYDIPVTGEWSFEEIELINNCLKNFLKKVKEKFDDYIVIAHLPEHYLEILELDDIVITSKGNPTSEEALKNLTDTLKKYKELTKSKDINKKGQRIHNIQQLAEFQFGINFIPNEIFINHKGQIFTKINNKNQQIASINPKNGLLILTLSGGELLWNSGGKDINYIEVNYEIKKGSLFPPGFVDCNENISYNDEVVLIKDDTFLGIGRALMSGFEMKKAKHGALVNIRNVKS
Protein: Protein dispatched homolog 1 (Protein chameleon) (Q6R5J2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sonic hedgehog protein
- Tiggy-winkle hedgehog protein
- Hedgehog protein
- Indian hedgehog B protein
- Desert hedgehog protein
- Cilium assembly protein DZIP1
- Bromodomain and PHD finger-containing, 1.
- Protein patched homolog 1
- Protein smoothened
Sequence:
MALSEDFTELQTLSNGRSSSIFPTTNTPVDPEEEEEQSVSACTQPNEHTQMMQTGQNGGLKSTRLSSSSSSSSQLTDAQRLAVLLPNALPPGFCVCCSLCCNGNQQDCALFQSAVPSAALHMGSCCVQGVPCFCMQHHWPEHLQNQPNMATLSPPRPFRFPKNYAELIADWPVVVLGICTVLIVVCALVGILVPDLPDFSNPLQGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHQDDRWSKDHYDRKKRQAEWDFSKDSFFCDVPGDSYSRIVFASAEGKNLWNIQAIKSMCNFDNTRVRSHPQYLDLCQRTTAASCCPSWTLGNYIAVLTNKSSCQKITERDVSHTLNILRSCAKFYHNGTLGPECWDMTTRKKDLKCGNLPRKCTKYNAVYQIFHFLVDKDFLNPKNTDYLPPNLKYSMLFAPTEKGETMMNIYLDNFENRNSSDGITTITGIEFGIKHSLFQDYLLTDTMYPAIAIVIVLVVMCVYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFDFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPNSELSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYILMVTWLPAVVVLHERYLVNLLTCSRTQNHQSQGAATFWTSLCQVVNKCLFSISEASRIFFEKVLPCVVIKLRYLWLLWFLALTVGGAYVVCVNPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVNHGEDLHMPITIIWGVTPIDSGDPLNPKNKGKLTLDTTFNIASPASQVWILNFCQKLRNQSFVYQSEEQDFTSCFMETFKQWMENQDCEEASVYPCCSQSTFPYRQDVFELCIKRAIMELDRSTIYHLDSKTPGPRFDINDTIRAIVLEFQSTYHFTLAYEKMHQFYREVDTWIQEELRDAPEGLSYGWFVSNLEFYDLQDSLSDGTLIAMALSVVVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPEPDREGKVVFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFLMLIMCISWAFATFFFQCMCRLLGPQGTCGQIPLPKKLQCAERTSENQSTVNNQGKAGACYTTKHEHYELEPLAANVRNEGKASDEEQEACTQLQNNITSLHDDATLCASHEEPKHEFENGVQATEHSHLHQYAFNTRCTCENSMHQYIRERQRTACHPCGQSRETQCATKQSNHLPVCLNRDMIHAPTNSGHFQHCTPSQISRPAAHRCFSGGCGMHAVHISQQQTETESYISACVPSSSPQESQNRPAHLQFPDVQRCSSPDTTGVCTLNHDTQNAGELAINSQSPQKIPWNHLKTKANGTCVLQDCREVVPEDSIGCRVDKEKTVSPKKFNCFKKNVNAKCNSVEFHKTRTSVPTIAINSKASSESLC
Protein: Fascetto (LD35624p) (Q9VZ62)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Kinesin-like protein
- EG:BACR25B3.9 protein
- LP17758p
- Inner centromere protein, isoform A
- Rac GTPase-activating protein 1
- Serine/threonine-protein kinase polo
- Kinesin-like protein Klp61F
- Kinesin-like protein at 67A, isoform A
- Anillin
- Borealin
Sequence:
MNSPSAIAVKAQILEMTGEHVDQLHAMWSQLFEVKTCGEFLLRLKDHANSFFTDLLNESREKQQAILNDIAALRAEATDLTRLLHEPLDIGERPESMPLVVWELKLDKSIEHLRDQLARRRAEICELLLQQEQLCEELGELPLPLLADPLPLPEEMDAFRNRLGQLRDQRVLRLKEMDQLRQAIKHDMKLLECLPQTDTEERLLNQVDHCLTPETFELLRNMQKNFADQVKELRERIDDMREKIHVLWDRLQETDEYAMRRVREATTYTQRTYDVLREELQRCQALRRQNLKTFIEQLRIEIKEMWDLTLKSQQERKRFSNYYNDWYNEDLLELHELELDDLKTFYNKNKEIFDLYESRAELWSRMEALEAKASEPNRFNNRGGQLLKEEKERKAITSKLPKIEQQITELVQAYEAQENTPFLVHGENILERMAADWERHRQAKQQSSARKKAPPSASKIMPPPATGSTAPRTPRTLRNMSTLSSSTMSLRKTPSQQHLRPLNITKSTGNLHKRLNPSGLQTGPKTPNAKRSLMNTLNSMKASPAKHLLAPSQQHNQLKSTKSPLKRVRVLDNTLRRSGGMGRRSIGTRSSKKARTKSNDQNAPPDSSDYTTDENPEQGVSYDEFQPTSRSSMLPRQRHQLAVPRTRRAEMNANLPVPRESLMIVQPRRQF
Protein: UPF0744 protein YSC83 (P32792)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16407407}; Peripheral membrane protein {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16407407}.
Interaction partners:
- Uncharacterized oxidoreductase YIR035C
Sequence:
MAWSGGKDIVDQIFDAGYWLVSKSAVLSDEIKNHVEKSIESISGKISNKETPRLQENDSNRSKVYKTLRIGLQDHWKLGLGISATSLCLYLGYRTFFKLPPNLPEAESQVVLILGDMNDPIIRNQVMDLYRRRFTVYICTENADVYKKHEEDQDFIYYIDPTCEKDFEGFFVDVPRLASILFMPRLSYHPSGVISCDSLESEIHSSIFVYYQALLSIIPHLKRKTQLIMFNPSLTADLNLVHHSTEIITSGIIDSLFKIFKEYQRLNVSTIKLGILQIGSQPSNYKFLRMAGSDIHEALHYPVYKMIMSANGYKLRQLLSWLTTLGGYNSVYYCGRFSYLVSWPFASLIFNHHTRLSLKRLRGRLAKVYSSIISFFCRSSSKSSK
Protein: Lectin29Ca (Q6GUX9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYKYATCIFSIFALWNFWGVSAKKQDTSTGTNELPKAPMPYYTIENIDMHQQHWFTYNSLRQNGTLWRIGNMEQRLEMRLQSFQNQMETKLRALKQQIEPYMENVKMSNKIKMSVFKKIGSRHFYLEKQKKMPWDSAYDTCRQMGGHLANILDEKELNEIFSEETKKNYWVDINSRANDGASWISTLSGRDVPFLKWKPNLATNIHNHCVYINSNEMYFENCANDNYFACQAEQWA