Protein: Centrosome-associated protein 350 (Cep350) (E9Q309)
Organism: Mus musculus (Mouse)
Function: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5VT06}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q5VT06}. Nucleus {ECO:0000250|UniProtKB:Q5VT06}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q5VT06}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5VT06}. Note=Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the pericentrosomal area. Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole. Localizes to the distal end of the centriole on the subdistal appendage region. {ECO:0000250|UniProtKB:Q5VT06}.
Interaction partners:
- Centrosomal protein 43
- Centrosomal protein of 19 kDa
- Centrosomal protein of 89 kDa
Sequence:
MRSSKSKEVPLPNPRNSQSKETIQDVTTSWDALSQTKAALRHIENKLEVTPTSTAVIDSVMDTKKSASATRKISRKDGRCLDDSWASAPTSKFSKPRKEKSRSPLRATTLESNVKKNNRVEFREPLVSYRETHGTPFSLSPSHLESKHVYCIHEEKPESGKQMVVSREDRNIQCCDFESAQPSVISDTVVRFLNDGPAIDALHSSECLMKMGVHVRTEDEMPNRTKGSENNSKPSLNNMEHDVDPKVMLLSDSSPSSSACNSQRSDISKRQQHDIKLEKLKERIRKQWEHSEEINGQAQTLGHIDHPVMVVNVDNSVTTKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAEFQSMSRELYRDLALQFTDDTSVKEKPVEKSKEKKVVKPVRKIQKVTQLSNPECKTGSSRLISTSSWRDGQKLVKKILGPAPKMEQKERRPTSNDRSGRERVAKFGGHIGRAESDPKLDVSHKQLPRSSARSRSSRAWSETNIVKSALSLPDNKQEESAALNKDFLPVEIRGILDDLQLDSSAQAVRQEAGEGQNQKSSAPEQVPRSHSPVKRKPDKITANEDPPVISKKRHYDTDEVRQYIVRQQEERRRRQHEEKKAQKEATEQKNKRLQELYRRQREAFSKAKTVPPSDPLVSRRLQETYSKLLLEKTLLEEPARQHVTQDIQARPGYQPSGESDKENKIQERPPSASSSSDLSLSEPPQPLARRDLMEPTWMQPDRLSPRVHSSQAQPLAGTTENLLSHLLHLEHVGILHKDYESVLPAKKSHNTASGPLTFTPQPYLTSQAPHPDALLKPSTSQYKTKLDRIEALKATAASLSSRIESEAKKLAGASINYGSVWNTECDVKLAPQENGPWTKAISPPVKEDIEDAFSARIQKMLGTCVSHAAFDDELPGVGSLSEYKKLPEMIRPQSAISSLRMKSPSPKPGGLLAQLCRRQTDSSSSDIQACSQERAKRSLCSSIDSVSEGPLLSEGSLSEEEERRDARPLLKVAEILKEKEFCAGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGFEDRGTLVSRPLNATATPLSSVSYEDDFVSSPGSGTLTERKSTLESQVDGSSLGVQEEHLSRQFACDLASVDATSQHSSGARSAGSTRSSSASKGKKGKKDKMDWLDSLTGSAQNPLIDEEKVQSDSERGSHPSRKLGTGSKLAVGDSEQTLDAESTLEDLSGHSVSGSSDKGRSQKTPTSPLSPSSQKLLQFDLPGTSLERSKSSVIVPPTTTGFKPTAAFTDVNKTEMASAPGPQRFSPAGLQHRMAAELSYLSALEESVRQLSDVERVRGIALAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALECQRQLEETRNKTAQVHAESLQQVVKSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHLADAITTSGVPLATLYDHQRQHFPDFMRKLRTKAETDRISHSASHSQSKEGAVDSKRQKFSPSRDSYSESSRYKSHDYRSSGSSRQDSPSVPPSKENEKPFHGEKMESSVDEQLQTAADDSLRSDSIPSLPDEKDSTSIATEYSLKFDESMTEDEIEEKSFRSLLPSESHRRFNMEKKRGHHDDSDEDASPDKTALSSTKELSMPFSGGQDSFSKFTMEMVRQYMKEEEVRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIERIRQTTIKLQEKLKSAGEKKLGSLADDDEAEDNKAASPGPPGLETRSPSPISISSSETSSIMQKLKSMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIQQMEKQALAAWDKELVKPRTPKKEQESQRTEQKGIASEEGSPMPSYSPRNSESCIPEDLGSPSDLCVPSEARVQAQPGSPEHSTLTEEMVFSQELESTSPSKHSPPKSCLSMSKQESSKASHRTEGHCHLPVKSHQPCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVEQLKREQRKRQKERLKAQEASLLRQLETYDEFIKKTEGELSQDLDISPTSKFQMKTLSSVSEKPKIKPHPLHRSETAKTWKSVTESERSRGSLASIAEHVDSSLSCSERAISERSLSAYAKRGVELDSRIEHLQASSPDLSSRKAQTESRDSLESAPSLSPVKELNAPDRIYDVSEAKAEDTSQKSEIQEIESMKLESSEVEDACCKQSGGSEVLLKLDLASETLSSKELPSDSANVQQDLDKPATETSHEKEEALKEDQSNHSTDDRSPDIQSAGGIPEQGCRESGDSTCSGQLSVPKESSYSEDFEVSSFRKGISADEISKDDSEGSSPSSLRKDSQSHRDRSQLTRSSRSRATGSGSDEEISECLGEKSLSVHSGVHSERLLELRSPTELMKSKERSDVGHEQGGTEPLPLAATEELLDFHIGDRVLIGSVQPGTLRFKGETDFAKGFWAGVELDKPEGNNNGTYDGIVYFVCKDKHGIFAPPQKISHLLENFDDTDINEDEESYSDEQYQPYNQEQKDIKCLKDRENNIAEYFCEKSLPSMHNTDASVDKDRSLNIETDTSEVLEVHGHQQPSVDPLISYKENKVLVSDATESVPAAAGAATSDNTFSGESKQQQLAEKEENFYSQVLEKPSTPLLDLLTREKNQLEAQLKSSISEEKKSKQQLETVSLLTDSLLQVFVKDTVSQLQQVKKARNEKIQLSNQEFLDQKKVPPQDLPQNTEEQSPSVPSCFLRSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELEISREFLSALDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRAPQKPCETLLAVPHTAEEVESLVHNAAEELWKWKELGQDLHGLSLPTTFLGGASKGLDIGSTSRRVYKQAVFDLTKEIFEEIFAEDPNVNQPVWMKPCRINSSYFRRVKNPNNLDEIKHFITTEVLKLLSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIKDTIDVLNQISEKQGRMLLV