wanglab/gogpt-training-data huggingface dataset:
Protein: Probable NAD(P)H dehydrogenase (Q9I4B3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- NAD
- NAD
- Probable NAD
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- NAD
- FMN-dependent NADH:quinone oxidoreductase 2
- Probable oxidoreductase
- NADPH:quinone reductase
- Quinone oxidoreductase
- HTH-type transcriptional regulator NmoR
Sequence:
MHALIVVAHHHPRSLTHALAARIAEGVVRAGHSAETADLAAEGFEPRFGLADHAVHRGQASPPADVLAEQARIDRADTLVLVYPIYWWSMPALLKGWIDRVFSNGWAFDYSIGGDLRKKLQRLRVVLVGVGGADAGTFERHGYAGAMRTQIDHGIFDYCGARVVRSELLLESESADPIRHLDQALHIGSQLFAARGAQGAAQAQPLEA
Protein: Ezrin (Cytovillin) (Villin-2) (p81) (P26040)
Organism: Mus musculus (Mouse)
Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cell projection {ECO:0000250|UniProtKB:P15311}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P15311}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P15311}. Cell projection, microvillus {ECO:0000269|PubMed:9472040}. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Microvillar peripheral membrane protein (cytoplasmic side). Localizes to cell extensions and peripheral processes of astrocytes (By similarity). {ECO:0000250|UniProtKB:P15311, ECO:0000250|UniProtKB:P31977}.
Interaction partners:
- Radixin
- Na
- Moesin
- Intercellular adhesion molecule 1
- Sodium/hydrogen exchanger 1
- CD44 antigen
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Na
- Podocalyxin
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVAEELIQDITQKLFFLQVKDGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMLREKEELMLRLQDYEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEADRMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGILDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM
Protein: Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) (Q9H8E8)
Organism: Homo sapiens (Human)
Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear.
Interaction partners:
- SAGA-associated factor 29
- ZZ-type zinc finger-containing protein 3
- YEATS domain-containing protein 2
- Histone acetyltransferase KAT2A
- Transcriptional adapter 3
- Histone acetyltransferase KAT2B
- MAP3K12-binding inhibitory protein 1
- Transcriptional adapter 2-alpha
- WD repeat-containing protein 5
- Protein Dr1
Sequence:
MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFFRFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEKLSASTLKIKAASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVASGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEKDTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFRHQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR
Protein: PALM2 and AKAP2 fusion (C9JA33)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}.
Interaction partners:
Sequence:
MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKGFSSTDGAVYAMEINVEKDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQKAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTDVSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM
Protein: Protein FAM53A (Dorsal neural-tube nuclear protein) (Q5ZKN5)
Organism: Gallus gallus (Chicken)
Function: May play an important role in neural development; the dorsomedial roof of the third ventricle.
Subcellular location: Nucleus {ECO:0000269|PubMed:11984880}. Note=Subnuclear distribution. {ECO:0000269|PubMed:11984880}.
Interaction partners:
- General transcription factor IIE subunit 1.
- Uncharacterized protein.
- Nonsense-mediated mRNA decay factor
Sequence:
MVTLITEKLQNQSLDDLTCKTYNINLYSSEKLNKSGSLFSFEINEDSPWKALNGGCPIQTDARNSAYPFPVCPFSTGPASNGALQWQQEPSSTSMVSGWISELNLNENSGQPLAPPTKRHCRSLSEPDELARCRSPWKPGNSKVWTPVSKRRCNSGGSATLQRCNSHGSATLQRSTSISLPQNILSLNNVFTVTSFNTSPVPRPSSASSGFVDSSEGSTSSSTRWNSGGPCDFNPRRRLSLSQEHITETGNLLPSANSTPTSTPELSRRQGLLRCRSQPCVLNEKKSRLKRRREEDVRWNRPSLDFFKMTRTLKNSKSLCSLDYEDDDDDTQMKTIVSSPCDSNDLMNIITPGSSPMKEQLDEVRHHGSCQGSFKTRDYKKAAAVCESDEDTSDCESTEEGIFPLDCGDLDLEQIENN
Protein: Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) (Q13144)
Organism: Homo sapiens (Human)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287}.
Interaction partners:
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 2 subunit 3
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 1
- Guanine nucleotide exchange factor MSS4
- E3 ubiquitin-protein ligase ARIH1
- eIF-2-alpha kinase GCN2
Sequence:
MAAPVVAPPGVVVSRANKRSGAGPGGSGGGGARGAEEEPPPPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNINITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGVRVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPEGSVISLHPPDAEEDEDDGEFSDDSGADQEKDKVKMKGYNPAEVGAAGKGYLWKAAGMNMEEEEELQQNLWGLKINMEEESESESEQSMDSEEPDSRGGSPQMDDIKVFQNEVLGTLQRGKEENISCDNLVLEINSLKYAYNISLKEVMQVLSHVVLEFPLQQMDSPLDSSRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEDFFLEHEALGISMAKVLMAFYQLEILAEETILSWFSQRDTTDKGQQLRKNQQLQRFIQWLKEAEEESSEDD
Protein: Platelet-derived growth factor receptor-like protein (D6RIG5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPV
Protein: Glycine-rich RNA-binding protein 7 (AtGR-RBP7) (AtRBG7) (Glycine-rich protein 7) (AtGRP7) (Protein COLD, CIRCADIAN RHYTHM, AND RNA BINDING 2) (Protein CCR2) (Small RNA binding protein 1) (AtSRBP1) (Q03250)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in RNA transcription or processing during stress. Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids. Displays strong affinity to poly(U) and poly(G) sequence. Involved in mRNA alternative splicing of numerous targets by modulating splice site selection. Negatively regulates the circadian oscillations of its own transcript as well as RBG8 transcript. Forms an interlocked post-transcriptional negative feedback loop with the RBG8 autoregulatory circuit. Both proteins negatively autoregulate and reciprocally crossregulate by binding to their pre-mRNAs and promoting unproductive splicing coupled to degradation via the NMD pathway. Involved in the regulation of abscisic acid and stress responses. Affects the growth and stress tolerance under high salt and dehydration stress conditions, and also confers freezing tolerance, particularly via the regulation of stomatal opening and closing in the guard cells. Exhibits RNA chaperone activity during the cold adaptation process. Involved in the export of mRNAs from the nucleus to the cytoplasm under cold stress conditions. Target of the Pseudomonas syringae type III effector HopU1, which could probably be involved in plant innate immunity. Component of the flowering autonomous pathway which promotes floral transition, at least partly by down-regulating FLC. Mediates cell-to-cell trafficking of RNA interference (RNAi) signals (small RNAs (sRNA), e.g. small interfering RNA (siRNA) and microRNA (miRNA)) which regulate growth and development, as well as responses to environmental inputs, including pathogen attack; can compromise zucchini yellow mosaic virus (ZYMV) and tobacco rattle virus (TRV) infections at the early stage.
Subcellular location: Cytoplasm. Nucleus. Secreted {ECO:0000269|PubMed:31812689}. Note=Shuttling between nucleus and cytoplasm. Relocalization from the cytoplasm into the nucleus is mediated by TRN1. Observed in the phloem translocation stream (PubMed:31812689). {ECO:0000269|PubMed:31812689}.
Interaction partners:
- Two-component response regulator-like APRR1
- Transportin-1
- Protein LHY
- RNA-binding
- Protein CCA1
- Cold shock protein 2
- Protein RALF-like 1
- THO complex subunit 4A
Sequence:
MASGDVEYRCFVGGLAWATDDRALETAFAQYGDVIDSKIINDRETGRSRGFGFVTFKDEKAMKDAIEGMNGQDLDGRSITVNEAQSRGSGGGGGHRGGGGGGYRSGGGGGYSGGGGSYGGGGGRREGGGGYSGGGGGYSSRGGGGGSYGGGRREGGGGYGGGEGGGYGGSGGGGGW
Protein: Diphosphoinositol polyphosphate phosphohydrolase 3-beta (DIPP-3-beta) (DIPP3-beta) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 11) (Nudix motif 11) (P0C028)
Organism: Mus musculus (Mouse)
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96G61}.
Interaction partners:
Sequence:
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPDGAAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVFVLTVTELLEDWEDSVSIGRKREWFKIEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSAAPSPPESEP
Protein: Enhanced serine sensitivity protein (A0A0H3NPR5)
Organism: Salmonella typhimurium (strain SL1344)
Interaction partners:
Sequence:
MSETKNELEILLEKAATEPAHRPAFFRTLLESTVWVPGSAAEGEAIVEDSALDLQHWEKEDGTTVIPFFTSLEALQQAVEDEQAFVVMPARTLFEMTLGETLFLNAKLPTGKEFMPREISLLLAEEGSPLSTQEVLEGGESLILSEVAEPPSQMIDSLTTLFKTIKPVKRAFLCAIKEHADAQPNLLIGIEADGEIEEIIHAAGNVATDTLPGDEPIDICQVRKGEQGISHFITEHIAPFYERRWGGFLRDFKQNRII
Protein: Nuclear pore complex-interacting protein family member A5 (E9PKD4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNCRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEKERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIIDNSLSLKTPSERLLYPLPPSADDNLKTPPECLLTPLPPSALPSADDNLKTPAECLLTPLPPSAPPSADDNLKTPPECVCSLPFHPQRMIISRN
Protein: Protein FeSII (FeSII) (Shethna protein FeSII) (Q44501)
Organism: Azotobacter vinelandii
Function: Binds to and protects nitrogenase from irreversible exposure to O(2), in what is known as 'conformational protection'. Shifts nitrogenase into an inactive, O(2)-tolerant state. Exists in 2 states, an open oxidized state that binds and protects nitrogenase, and a closed reduced state that probably does not bind nitrogenase; cooperative oxidation of the 2Fe-2S clusters causes the conformation change. Does not protect nitrogenase with the vanadium-iron subunit, not clear if it protects the iron-only nitrogenase.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:26654855}.
Interaction partners:
Sequence:
MATIYFSSPLMPHNKKVQAVAGKRSTLLGVAQENGVKIPFECQDGNCGSCLVKITHLDGERIKGMLLTDKERNVLKSVGKLPKSEEERAAVRDLPPTYRLACQTIVTDEDLLVEFTGEPGGA
Protein: Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Q7TP05)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Complement factor D
- Complement C4
- Complement factor H
- Complement factor I
- Complement C3
- Plasma protease C1 inhibitor
- Complement C2
- Complement factor B
Sequence:
MAPLLALLALLQLGPGLAALSCPQNVNIVGGNFTLSRGWAPGSVLIYSCPLGRYPSPAWRECQSNGQWQTPRASSLPTLRSSRLAKAVCKPVRCPAPTSFENGIYIPRLGSYPVGGNLSFECEHGFTLRGSPVRYCRPNGVWDGETDHENATGTNTYEALNSVYLMMNNQMDRLGMETSAWQEIRHAIILLTDGKSNMGGSPKPAVDNIREILGISRNRNDYLDVSKLTDTICGVGNMSVNASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDAQMEDRHLWRVIVGDPTSHHGKEFHVEEVLVAPGFNVHAKQSQGISEFYADDIALLKLSQRVKMSSHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRMNINLRTGPERTSCIEAVSQNKGSFPGLTNVSEVVTDQFLCSGMEGDDSPCKGGPAIRCPRPQDFENGEFWPRSPYYNLSDQISFQCYDGYTLRGSANRTCQENGRWDGQTAICDDGAGYCPNPGIPIGTRKVGSQYRLEDTVTYHCSRGLVLRGSQQRRCQEGGSWSGTEPSCQDSFMYDSPQEVAEAFLSSLTETIEGADAEDGHSPGEQQKRKIILDPSGSMNIYMVLDGSDSIGASNFTGAKRCLANLIEKVASYGVKPRYGLVTYATVPKVLVRVSEERSSDADWVTEKLNQISYEDHKLKSGTNTKKALQAVYSMMSWPGDAPPEGWNRTRHVIIIMTDGLHNMGGDPVTVIEDIRDLLDIGRDRKNPREDYLDVYVFGVGPLVDPVNINALASKKNNEQHVFKVKDMEDLENVFYKMIDETKSLGLCGMVWEHQKGGDYYKQPWQAKISVTRPLKGHENCMGAVVSEYFVLTAAHCFTVEDQKHSIKVNVEGKRRDLEIEEVLFHPNYDINGKKAEGISEFYDYDVALIKLKTKLKYSQTLRPICLPCTEGTTRALRLPQTATCKQHKEELLPMKDVKALFVSEEGKKLTRKEVYIKNGEKKASCERDATKAQGYEKVKVASEVVTPRFLCTGGVDPYADPNTCKGDSGGPLIVHKRSRFIQVGVISWGVVDVCKDPRRQQLVPSYARDFHINLFQVLPWLKEKLKDEDLGFL
Protein: Oligopeptide transport system permease protein OppB (P9WFZ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:38548954}; Multi-pass membrane protein {ECO:0000269|PubMed:38548954}.
Interaction partners:
- Oligopeptide transport system permease protein OppC
- Oligopeptide-binding protein OppA
- Oligopeptide transport ATP-binding protein OppD
- Probable dipeptide-transport ATP-binding protein ABC transporter DppD
- Probable dipeptide-transport integral membrane protein ABC transporter DppC
- Uncharacterized lipoprotein Rv2585c
- Probable periplasmic dipeptide-binding lipoprotein DppA
- Beta-carbonic anhydrase 1
Sequence:
MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPPQAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVVGSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVGIQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQDFIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWMVRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.27) (M9PDZ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDEDDNLSNADISIDDEEVVREQTHHPPMQEDQELDNEDGSSDVDLSSVYVVPPIVSAPSPASVRIAGGSTIGGGGVAAGAVPTTTDNSHSPFHDWDSSVAAAAAPPPPPPRTGPTTTTSSGTAAESGAASALSDDAGAKPSFFFGASSFSLRSRKEVAALINTECCRGSPTPDLDSIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKIVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFREHSDTPLEVQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLKANREKYEDAVNRFPNPEPPDEYRDLPALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLHDPNKNFHFVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFMEARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETAPLKQPQKAEQSSMLEGFLTFLATLVTSRTNLGNDEATQCIIEISALLATENKTHSQLLELMPERSGNVHTKNFETFLKKLSVYKAPSSGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIFFRAVHTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHEPPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKEYDCIICNCTTPSTESNPIGLVVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQDRGEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSGNQPFERLVADLTDLIKENETIPQPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKLFIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGLPVTATEPLPAHCLELIPSILADPIALLLKFILLAPLQLDQDYFTCMVKVMYNLLYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQPRLLELPREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEAVRHTLSCGGGIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSHKFAHTKHTWVFHRDLLXNMEDLLRSIQELVGQI
Protein: Exoglucanase 2 (EC 3.2.1.91) (1,4-beta-cellobiohydrolase) (Cellobiohydrolase 6A) (Cel6A) (Exocellobiohydrolase II) (CBHII) (Exoglucanase II) (P07987)
Organism: Hypocrea jecorina (Trichoderma reesei)
Function: Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose (Ref.3). The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-glucosidic bonds in cellulose to reduce the polymerization degree of the substrate and create new chain ends for exocellobiohydrolases (CBHs). The CBHs release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units (Probable).
Subcellular location: Secreted {ECO:0000269|Ref.3}.
Interaction partners:
Sequence:
MIVGILTTLATLATLAASVPLEERQACSSVWGQCGGQNWSGPTCCASGSTCVYSNDYYSQCLPGAASSSSSTRAASTTSRVSPTTSRSSSATPPPGSTTTRVPPVGSGTATYSGNPFVGVTPWANAYYASEVSSLAIPSLTGAMATAAAAVAKVPSFMWLDTLDKTPLMEQTLADIRTANKNGGNYAGQFVVYDLPDRDCAALASNGEYSIADGGVAKYKNYIDTIRQIVVEYSDIRTLLVIEPDSLANLVTNLGTPKCANAQSAYLECINYAVTQLNLPNVAMYLDAGHAGWLGWPANQDPAAQLFANVYKNASSPRALRGLATNVANYNGWNITSPPSYTQGNAVYNEKLYIHAIGPLLANHGWSNAFFITDQGRSGKQPTGQQQWGDWCNVIGTGFGIRPSANTGDSLLDSFVWVKPGGECDGTSDSSAPRFDSHCALPDALQPAPQAGAWFQAYFVQLLTNANPSFL
Protein: Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) (P70392)
Organism: Mus musculus (Mouse)
Function: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.
Interaction partners:
- Ras-specific guanine nucleotide-releasing factor 1
- Glutamate receptor ionotropic, NMDA 2B
- GTPase HRas
- GTPase KRas
- Rho-related GTP-binding protein RhoC
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
Sequence:
MQKSVRYNEGHALYLAMLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHDGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIATNQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHVHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAETEYVHQLYILVNGFLRPLRMAASSKKPPINHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDGSDDDPKGSGHMFGHLDFKIVVEPPDAASFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVLAKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTNSSSSSSPTTTTHSPAASPPPHTAVLESAPADKAGDSADMSPCRSPTTPRHLRYRQPGGQVADSAHCSVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDSLYELSLKIEPRLPA
Protein: Thioredoxin-like protein (Q57W40)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BolA-like protein
- BolA-like protein
- Anamorsin homolog
- Tryparedoxin
- Tryparedoxin
Sequence:
MKRVGTLEEYTKVKRDANGLGLVVHFSASWCEPCKGVTEALERFSELYKGSVEFVEVDSEALGSICEAEAVDCVPYIAFFRTSGDGKGQERVADVVGGKLDQIEQNMLSLYGDGTDGRGSFSDLQSYLKYLTSRKGVVAFITGTPSRPRCGFTVKLIQLLDDLHVKYVYYDVWASDEVCEGLKKYSEWPTFPQVYADGEFIGGYDICAELNASGELKSALKL
Protein: Profilin (Q5A786)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Actin
- Formin BNR1
- Formin BNI1
- Cofilin
- Adenylyl cyclase-associated protein
- Actin-related protein 2
- Centractin
- Fimbrin
- Actin cytoskeleton-regulatory complex protein SLA1
- Msb1p
Sequence:
MSWQAYTDNLIANGKVDKAALYSRAGDALWAQSGSFELQQPEITEIAKGFDSAEGLQTSGLHVQGQKYFLLRADDRSIYGKHEAEGVICVRTKQTILIAHYPSGVQPGEATTLVEKLADYLINVGY
Protein: Non-specific lipid-transfer protein 3 (LTP 3) (Q9LLR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
Interaction partners:
- Transcription factor MYB96
- Non-specific lipid-transfer protein 15
- Non-specific lipid-transfer protein 9
- Serine/threonine-protein kinase WNK
Sequence:
MAFALRFFTCLVLTVCIVASVDAAISCGTVAGSLAPCATYLSKGGLVPPSCCAGVKTLNSMAKTTPDRQQACRCIQSTAKSISGLNPSLASGLPGKCGVSIPYPISMSTNCNNIK
Protein: Vesicle-associated membrane protein, putative (Q38CG1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vesicle-associated membrane protein, putative
- Vesicle-associated membrane protein, putative
- Syntaxin, putative
- Vacuolar protein sorting 33, putative
- Vesicle transport v-SNARE N-terminal domain-containing protein
Sequence:
MQGGTKIYGGVVVRLTDRLLLCKAPGFTTSDFSIPELMWAELVSKCAAPNMRTSSTMMANNATSSGSAAPQLSYHICTDNELAFAILSDMGLTRHKAHATLDEASKTFRKMFVESVASFTPKAVEVFVKPYRDLLLRSSDGGSSDDKVNKVKKAVDEVKEIALDNVERVMQRGQRIDDIVRSTEDLQLQAQGFQRSSRDLRQQMWWSSVKGKLLIAGVALFFILIVVFVFVGGKKEEKK