wanglab/gogpt-training-data huggingface dataset:
Protein: Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: Brain natriuretic peptide 45 (BNP-45) (5 kDa cardiac natriuretic peptide) (Brain natriuretic peptide) (BNP)] (P13205)
Organism: Rattus norvegicus (Rat)
Function: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (By similarity). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis.
Subcellular location: [Brain natriuretic peptide 45]: Secreted {ECO:0000269|PubMed:2525379, ECO:0000269|PubMed:2528349}.
Interaction partners:
- Atrial natriuretic peptide receptor 1
- Atrial natriuretic peptide receptor 3
- Natriuretic peptides A
- Atrial natriuretic peptide receptor 2
- Myosin-7
- C-type natriuretic peptide
- Troponin I, cardiac muscle
- Troponin T, cardiac muscle
- Myosin-6
- Angiotensinogen
Sequence:
MDLQKVLPQMILLLLFLNLSPLGGHSHPLGSPSQSPEQSTMQKLLELIREKSEEMAQRQLSKDQGPTKELLKRVLRSQDSAFRIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF
Protein: POU domain protein (Q7SZN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MMSMNSKQPHFAMHPSLPEHKYTTLHSSSEAIRRACLQTPQLQSNIFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNTVPCSSTSTVPLAHHHHHHHHHHHQNLEPADLMEHITSPSLALMPSAHEGAGGGGGGGGGGGLISTSAHPHSHMHGLTHLSHQAMNMNSPLSHHGLLPGHHGGAHQGAPGLVNNGLPSINDSDTDPRELEAFAERFKQRRIKLGVTQADVGGALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMSKPDIFNGSEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRLKFSAAH
Protein: Uncharacterized isomerase C186.06 (EC 5.1.-.-) (Q9P7P9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative amidase C869.01
- Uncharacterized protein CPT2R1.02
- Uncharacterized transcriptional regulatory protein C11D3.11c
Sequence:
MSIKLGYLFKLPSYKTSSISPEVIVDLEKFLNLCEGSCSQCNTPFCVDVGPRNAIIQLPNGADVLNLNPNFQAIFECCSKNSLTGVQIFGMYNDGTYELRSFCPVHGVNEDPANGSGAGSVGVFFALNNPSIISSDFAHLLFNQGKILGRNALIRVAIKLSANGLYDIHVGGGSKICISGTAEI
Protein: Cationic amino acid transporter 9, chloroplastic (Q9C5D6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Permease involved in the transport of the cationic amino acids.
Subcellular location: Plastid, chloroplast membrane; Multi-pass membrane protein.
Interaction partners:
- Amino acid permease 1
- Cytochrome b561 and DOMON domain-containing protein At2g04850
- WAT1-related protein At3g28100
- WAT1-related protein At4g15540
- WAT1-related protein At3g28130
- WAT1-related protein At3g28070
- WAT1-related protein At4g01430
- WAT1-related protein At3g28050
- WAT1-related protein At3g28080
- Probable polyamine transporter At1g31820
Sequence:
MGGHEGFSNQRLSSATWFSHFRASALRSKSLPPPSSQTAVRSTSGDSLVRRLGLFDLILLGVGASIGAGVFVVTGTVARDAGPGVTISFLLAGASCVLNALCYAELSSRFPAVVGGAYMYSYSAFNEITAFLVFVQLMLDYHIGAASISRSLASYAVALLELFPALKGSIPLWMGSGKELLGGLLSLNILAPILLALLTLVLCQGVRESSAVNSVMTATKVVIVLVVICAGAFEIDVANWSPFAPNGFKAVLTGATVVFFSYVGFDAVANSAEESKNPQRDLPIGIMGSLLVCISLYIGVCLVLTGMVPFSLLSEDAPLAEAFSSKGMKFVSILISIGAVAGLTTTLLVGLYVQSRLYLGLGRDGLLPSIFSRIHPTLHTPLHSQIWCGIVAGVLAGIFNVHSLSHILSVGTLTGYSVVAACVVALRLNDKKDRESSNRWTSSWQEGVICLVIIACSGFGAGVFYRFSASVIFILLSVGVAVVASAVLHYRQAYALPLGSGFSCPGVPIVPSVCIFFNIFLFAQLHYEAWIRFVVVSVLATAVYALYGQYHADPSMLDYQRAPETESDA
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (A0A0H3NF38)
Organism: Salmonella typhimurium (strain SL1344)
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAYAGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPATTAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRFDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREKQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN
Protein: Small ribosomal subunit protein uS11 (30S ribosomal protein S11) (BS11) (P04969)
Organism: Bacillus subtilis (strain 168)
Function: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Interaction partners:
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL6
- DNA-directed RNA polymerase subunit alpha
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein uL4
Sequence:
MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAISWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRALQAAGLEVTAIRDVTPVPHNGCRPPKRRRV
Protein: Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) (Q13595)
Organism: Homo sapiens (Human)
Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:9546399}.
Interaction partners:
- Serine/arginine-rich splicing factor 10
- Serine/arginine-rich splicing factor 6
- Serine/arginine-rich splicing factor 1
- Serine/arginine-rich splicing factor 7
- Serine/arginine-rich splicing factor 3
- Transformer-2 protein homolog beta
- U2 snRNP-associated SURP motif-containing protein
- Dual specificity protein kinase CLK3
- ATP-dependent RNA helicase DHX15
- Serine/arginine-rich splicing factor 8
Sequence:
MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY
Protein: Sinuous (Q9VRM3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Neurexin-4
- EG:80H7.2 protein
- Lachesin
- Neuroglian
- Contactin
- Sodium/potassium-transporting ATPase subunit alpha
- FI21252p1
- UPAR/Ly6 domain-containing protein crok
- LP07906p
- FI18641p1
Sequence:
MQKPSHFAREDSQEHLPTSHTQNSHTVNMKRRTLSGSCGVGVFVFAFAFIVIAFATPSWLVSDYRITGAKLDRLGLWVHCFRSLPDVNDDSQRRFFVGCRWVYDPFTTGYDEIRGFLLPAFMIATQFFYTLAFIGMLVSAIGVLVFILCAGPDQKHFITLIKSLGYVLLGAGVSAAIAVIVFAGFGNRNGWMPEHANNWFGWSFILACVGTVLTLVASTLFLSEAHVQHKKRIQFKESQTRFELVRG
Protein: Glutamine synthetase (EC 6.3.1.2) (A8WCU8)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSLLTDLVNLNLSDCTDKIIAEYIWIGGSGMDLRSKARTLSGPVSDPSKLPKWNYDGSSTGQAPGEDSEVILYPQAIFKDPFRRGNNILVMCDAYTPAGEPIPTNKRCNAAKIFSHPGVAAEEPWYGIEQEYTLLQKDVKWPIGWPLGGYPGPQGPYYCGVGVDKAYGRDIVDSHYKACLYAGINISGINGEVMPGQWEFQVGPAVGISAGDELWVARYILERITETAGVVLSFDPKPIQGDWNGAGAHTNYSTKSMRSDGGYEVIKKAIEKLGLRHKEHIAAYGEGNERRLTGRHETADINTFLWGVANRGASIRVGRDTEKAGKGYFEDRRPASNMDPYVVTSMIAETTILWKP
Protein: DNA-directed RNA polymerase subunit alpha (PEP) (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (RNA polymerase subunit alpha) (Q6ENE2)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Uncharacterized protein
- Small ribosomal subunit protein uS8c
- Small ribosomal subunit protein uS14c
- S5 DRBM domain-containing protein
- Small ribosomal subunit protein uS12c
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein
- Uncharacterized protein
- Small ribosomal subunit protein uS17c
- Large ribosomal subunit protein bL33c
Sequence:
MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRTASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPTDFRIELRIKRDRGYHTEVRKNTQDGSYPIDAVSMPVRNVNYSIFACGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENKNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKHLPMDLPKNKF
Protein: Axin-1 (Axis inhibition protein 1) (P57094)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O15169}. Nucleus {ECO:0000250|UniProtKB:O15169}. Membrane {ECO:0000250|UniProtKB:O35625}. Cell membrane {ECO:0000250|UniProtKB:O35625}.
Interaction partners:
- Catenin beta-1
- [tau protein] kinase
- Low density lipoprotein receptor-related protein 5
- Glycogen synthase kinase-3 beta
- Glycogen synthase kinase-3 beta
- APC regulator of WNT-signaling pathway
- Casein kinase I isoform alpha
- APC membrane recruitment protein 1
- Dishevelled segment polarity protein 2.
- Dishevelled segment polarity protein 3a
Sequence:
MSMSVNEKGICYLPDLGSSFTEDAPRPPVPGEEGDLVSSDGRQYNHSFYSSKSDSLKNEASIATPRRPDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDGNEKMLKLAKAIYKKYILDNNGIVSRQIKPATKSFIKDCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLEYTRTGGESPKLFSDQSSVSGNGKVLPGYLPTVIEDVEWRCDQEEEQIAESDPTPSNRLTQKLPLETVPQRVANSKRYQDNREYRHASWREPVNPYYVNSGYALAPATSANDSEQQSMSSDADTLSLTDSSVDGVPPYRYRKPHRREIHESAKVNGRVPLPHIPRTNRIPKDIHVEPEKFAAELISRLEGVLREREAQEKLEERLKRVRLEEEGDDADISTGPSLANHRVPPAVHVQHYGGRYSEMSYNGLQLRDAHEENPESILDEHVQRVMKTPGCQSPGTGRHSPKSRSPDGLPAGKIPGLMMPLSGGQGKHQARQGPKGEAAHLHHHKHIHHTHYAAAGKPKEQAEAEAARMHGGFAWNTEQHHYGPKSRNYADGMSVGPNTMDPMGYSSKGSTLSKRPVRKGEDGRNFEMREPLPADDMERNQKILQWMMEGEKEAGRYKRGPYGSISGPKKAQGHEPARPSSVERLGAVHPWVTAQLRNNVQPSHPFIQDPTMPPNPAPNPLTQLEEARRRLEEERRKSGTLQAKQRHKNMKKQPCENITVAYYFRGEPIPYRTSVKGRIVTLGQFKELLTKKGSYKYYFKKVSYEFDCGVVFEEVREDDAILPIFEEKIIGKVEKVD
Protein: Oxysterols receptor LXR-alpha (A0A060VSG9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- Retinoic acid receptor RXR
- Uncharacterized protein
- Retinoid X receptor beta
- NR LBD domain-containing protein
- NR LBD domain-containing protein
- Retinoic acid receptor RXR
- Retinoic acid receptor RXR
- NR LBD domain-containing protein
- Retinoic acid receptor RXR
- NR LBD domain-containing protein
Sequence:
MKHEGNLLPLEPPHHAGFSSPPQKGPSSLAEKSSPLLMDPSNIKADPAGDMPANTEGQPVKRKKGPAPKMLGNEVCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKSAQYSCKNNGRCEMDMYMRRKCQQCRLRKCREAGMLEQCVLSEEQIRGKKMKKNEEETARTSAVVTPTPVPEVVPLEPEQLEMIEKLVAMQKQCNKRSFIDRPKVTVIPWPQSQDPQNREVRQQRFAHFTELAIMSVQEIVDFAKQLPGFLELTREDQIALLKTSTIEIMLLETSRRYNPAIESITFLKDFSYNKEDFAKAGLQLEFINPIFEFSKGMNDLHLDEAEYALLIAINIFSADRPNVQDHELVERLQQPYVNALRSYIMIKRPNDHLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Protein: uridine/cytidine kinase (EC 2.7.1.48) (A0A0S2Z5Y6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVVILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNG
Protein: Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed] (Q7Z6M4)
Organism: Homo sapiens (Human)
Function: Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:22949673, ECO:0000269|PubMed:23022348}.
Interaction partners:
- 5-cytosine rRNA methyltransferase NSUN4
- Mitochondrial ribosome-associated GTPase 1
- Mitochondrial assembly of ribosomal large subunit protein 1
- Mitochondrial ribosome-associated GTPase 2
- rRNA methyltransferase 2, mitochondrial
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein uL14m
- Large ribosomal subunit protein uL24m
Sequence:
MAAFGRQVLDWHRLIPLTWACMARQTPHLGEQRRTTASLLRKLTTASNGGVIEELSCVRSNNYVQEPECRRNLVQCLLEKQGTPVVQGSLELERVMSSLLDMGFSNAHINELLSVRRGASLQQLLDIISEFILLGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSYLQKLGLGEGKLKRVLYCCPEIFTMRQQDINDTVRLLKEKCLFTVQQVTKILHSCPSVLREDLGQLEYKFQYAYFRMGIKHPDIVKSEYLQYSLTKIKQRHIYLERLGRYQTPDKKGQTQIPNPLLKDILRVSEAEFLARTACTSVEEFQVFKKLLAREEEESESSTSDDKRASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDDEEE
Protein: Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa) (P24855)
Organism: Homo sapiens (Human)
Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:2277032}. Zymogen granule {ECO:0000305}. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Interaction partners:
- Deoxyribonuclease-2-alpha
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
Protein: Uncharacterized protein C16C9.05 (Q09819)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Chromatin modification-related protein eaf3
- Paired amphipathic helix protein pst2
- RbAp48-related WD40 repeat-containing protein prw1
- Histone deacetylase clr6
- Uncharacterized protein C2F7.07c
- Paired amphipathic helix protein pst3
- Paired amphipathic helix protein pst1
- Transcriptional regulatory protein rxt2
- Transcriptional regulatory protein sds3
- Chromatin modification-related protein png2
Sequence:
MASSINNSSQPTVPSISNNSHGDSFVNEGPPSNFKNNSLTSSTHSSTDHVNVLPISQDKEMDISSPVKKQKASYSNKSPNKAPIQKSRGSSLKSHLETESQQTPVKRRRRKATIRNVDYCSACGGRGLFICCEGCPCSFHLSCLEPPLTPENIPEGSWFCVTCSIKSHHPPKHPLSIWSQLYDWIDSQNPSQYRLPDDLVHYFHGISRGDTGAYKETEGEMDTDEFSALPTGSSITNLAYCGYCSKPSMGACWVYGCQLCDTFYHKNCKEHAKKCSHDSIGKKGMRVPKNAVVIRTPLVLDTTSNTLNPKVMISGWQFLMGEFPSDELLYFPRLPVSCLYKVSEDGLIKDFLYAIGIEAKKFNNERKKRELEVIPPDVKSALLPARTHPNLPIALRTLFNKART
Protein: Filaggrin-2 (FLG-2) (Intermediate filament-associated protein) (Q2VIS4)
Organism: Mus musculus (Mouse)
Function: Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q5D862}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q5D862}.
Interaction partners:
Sequence:
MAYLLRSVVTIIDVFYKYTKQDEECGTLSKDELKELLEKEFRPILKNPDDPDTVDVIMHMLDRDHDRRLDFTEFILMIFKLALACNKVLGKEYCKASGSKKHRRGHQHQEEESETEEEEETPRQKSGFRFSSWSEGEEHGHSSGGSRGPAKHRRGSNSKRLERQDELSSSEESRKKHHGSIFGHSWSSNKEKDGSRSEELGEKGDKSYDSPSRESEEEYESGYRLNHQGREGHSGLSCGLEKNKYELNYIQLRKGGEQKLGYNTSSSGNSKIQSHVYGFSNSSGCCRPKNASSSCQASRSQGQGNQSCRTQSNCQSGTSGGQGYGCVSEGQSSRCCQPKPRSCSQSSSQRGYGSKQCGQPQNCGRQQRMGSSHSSCCGPYGSGATQSSGCGQQRMSSCGHSSSSHQKGCSSNGFSKGDQRASGSGHSSCCEQHGTNSSQSSGFKQHGHESGQSCCGQHGTASSQSSGYSQHRVGSGQSCHYGQHGSSSGQSSSSGRHGSGSGQSSSSRHNRSGSSQSSGLEEHGSSSHQSHSSGHHGSGSRQSSGSEQHGAVSGQSSGSGKHETGPSQSSSSGHHGSGSQQHGGGSGQSTGFGEHESSSGHSSSSGQHRSGSRHSSGSGKHESGRSQSSGSGHHGSGSQQHGGGSGNSTGFGEHGSSSHPLPSSGQNESSSGQSSRSERHGTGSGQSSGFGQHGSGSHQSSSSGHNEYGSGQTSSSWPHGKGSGQESGYGEQESGHGQSSSSWQHGTGPGQSSSSEEEESRPGQSSSSWQHGKGSGQESGYGEQEAGHGQSSSSWQHGTGAGNQSSGYGEHKSGPSHSSRSWHHGTGSGQSLGFGQHGKGSHQSESSGHYESVSEPSSSSWQHGNGSGESYGYGEHESGHGQSSSAWNHGNESGQSNGYGEHESGHGQSSSAWNHGNESGQSNGFGENESGRDQEGYQQRESFHGQHRHPLSQHEQHSQFGYGRSPRSPVHPESSEGEEHSVVPRRYSGYGHGQGQAGHQQRESGYGQRGRPQGPSQDSSRQPQAGHGQPSQSGYGRSPRRSQVHPEYSEGEAHSEVSQRHSGSSHCHCHCHGQARHQQRESVHGQRGRPQGPSQDSSRHPQAGPGQPSQSGSRRSPRSQPVHPESSEGEEHSVVPQRHSGSGHGHGQGQGQAGHQQRESVHGQQGRPQGPSQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRHSGSGHGHGQGQGQGQAGHQQRESVHGQRSRPQGPFQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRHSGSGHGHGQGQGQAGHQQRESVHGQPVRPEVPTQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRNSESCHCHCHDQAGHQQRESVHGQRGRPQGPSQDSSRHPQAGPGQPSQSGSRRSPRSSPVHPESSEGEEHSVVPQRHSGSGHGHGQGQGQAGHQQRESVHGQRGRPQGPTQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRHSGSGHGHGHGQGQGQAGHQQRESVHGQRGRPQGPSQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRYSGSGHGHGQGQAGHQQRESVHGQRGRPQGPSQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVIPQRHSGSGHSHGQGQVHAEHQQRESVHGQRGRPQGPSQDSSRQPQAGQGQPSLSGSGRSPRRSPVHPESSEGEEHSVVPQRHSHSESGHGHGQGQGQAGHQQRESVHGQRGRPQGPSQDSSRQPQAGQGQPSQSGSGRSPGRSPVHPESSEGEEHSVVPQRHSESGHGHGQGQGQAGHQQRESVHGQRGRPQGPSQDSSRQPQAGQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRHSGSGHGHGQGQGQAGHQQRESVHGQPVRPQGPSQDSSSQPQASQGQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRHSGSGHGHGQGQGQAGHQQRESLHGQRGRSQSPFHPSHSIHWQSKCTISKKSSRLSGHYGRNHFQSTISGNQYDSSQSSRHGSYGPQDYDYGQSGYGPSGRLRSNSQSSIPFSSAHRATNMEVLPCGQSFSPSDHVGTKANEQIGELVFKYRESETGPDQSVDYYNLTESNSTTRGHECSHGHSVVVPEHSDDSDFNYGHSYNGKQQICQSQPTVQSCFDDSQYILFQKHLESPSFGNQSGFSPNERQLYTCNESIDSYHLSSDSNNRNQIYSSNNSFPNLYCIGTEQCIYLPSATILGEGTEGQEPGYTQPGTICKYNQFLDGRKSRTRGNHETGKMKSGSAYLDSNTPLYTYVQEQKSYYFE
Protein: BTB/POZ and MATH domain-containing protein 2 (Protein BTB-POZ AND MATH DOMAIN 2) (AtBPM2) (Q9M8J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:19843165}.
Interaction partners:
- Cullin-3A
- Cullin-3B
- T1B9.12 protein
- PEARLI 4 protein family protein)
Sequence:
MDTIRVSKEVPGSSKSTAQSLTESTSRTETINGSHEFKISGYSLVKGMGIGKYVASDTFMVGGYSWAIYFYPDGKSPEDNSVYVSLFIALASEGADVRALFELTLVDQSGNERHKVHSHFGRTLESGPYTLKYRGSMWGYKRFFKRSLLESSDYLKDNGLLVRCCVGVVKSRTEGPRCYNIPVPVSGLGQQFGKLLESGKGADVTFEVDGETFPAHKLVLAARSAVFRAQLFGPLRSENTNCIIIEDVQAPIFKMLLHFIYWDEMPDMQDLIGTDLKWASTLVAQHLLAAADRYALERLRTICESKLCEGISINTVATTLALAEQHHCFQLKAACLKFIALPENLKAVMETDGFDYLKESCPSLLSELLEYVARLSEHSLTSSGHRKELFADGCDLNGRRVKQRLH
Protein: Fibroblast growth factor receptor (EC 2.7.10.1) (A0A8I5Y7R6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MVVPACVLVFCVAVVAGVTSEPPGPEQRVGRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTLWAKDGVGLVASHRILVGPQRLQVLNATHEDAGVYSCQQRLTRRVLCHFSVRVTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDRELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELMEVDEAGSVYAGVLSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGGPRT
Protein: Calcium-dependent protein kinase 7 (EC 2.7.11.1) (Calmodulin-domain protein kinase CDPK isoform 7) (Q38873)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12913141}; Lipid-anchor {ECO:0000269|PubMed:12913141}.
Interaction partners:
- Respiratory burst oxidase homolog protein C
- Alpha/beta-Hydrolases superfamily protein
Sequence:
MGNCCGNPSSATNQSKQGKPKNKNNPFYSNEYATTDRSGAGFKLSVLKDPTGHDISLQYDLGREVGRGEFGITYLCTDKETGEKYACKSISKKKLRTAVDIEDVRREVEIMKHMPKHPNVVSLKDSFEDDDAVHIVMELCEGGELFDRIVARGHYTERAAAAVMKTIVEVVQICHKQGVMHRDLKPENFLFANKKETSALKAIDFGLSVFFKPGEQFNEIVGSPYYMAPEVLRRNYGPEIDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDSAKDLVRKMLEPDPKKRLTAAQVLEHTWILNAKKAPNVSLGETVKARLKQFSVMNKLKKRALRVIAEHLSVEEAAGIKEAFEMMDVNKRGKINLEELKYGLQKAGQQIADTDLQILMEATDVDGDGTLNYSEFVAVSVHLKKMANDEHLHKAFNFFDQNQSGYIEIDELREALNDELDNTSSEEVIAAIMQDVDTDKDGRISYEEFVAMMKAGTDWRKASRQYSRERFNSLSLKLMRDGSLQLEGET
Protein: EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) (Q99K41)
Organism: Mus musculus (Mouse)
Function: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9Y6C2}. Note=Found mainly at the interface between amorphous elastin and microfibrils. {ECO:0000250|UniProtKB:Q9Y6C2}.
Interaction partners:
- Integrin alpha-4
- Vitronectin
- Integrin beta-1
- Integrin beta-3
- Integrin beta-5
- Integrin alpha-5
- Integrin beta-4
- Integrin beta-2
- Integrin beta-7
- Integrin beta-2-like protein
Sequence:
MAPRALWSCYLCCLLTIATEAASYPPRGYSLYTGGTGALSPGGPQAQNSPRPASRHRNWCAYVVTRTVSCVLEDGVETIVKPDYQPCGWGQPHCSRSIMYRSFLRPRYRVAYKTVTDMEWRCCQGYGGDDCGEGPASVLGPAPSTPLPRPRPVRPNLSGSSAGSHLSGLGGEGPVESEKVQQLERQVKSLTKELQGLRGVLQGMNGRLAEDVQRAVDTVFNGRQQPADAAARPGVHETLSEIQQQLQLLDNRVSTHDQELGHLNNHHNGGPGGGGRASGPVPVPSGPSEELLRQLERQLQESCSVCLTGLDGFRQQQQEDRERLRTLEKLMSSMEERQQQLVGPAMARRPPQECCPPELGRRVSELERRLDVVTGSLTVLSGRRGSELGGAAGQGGHPPGYTSLASRLSRLEDRFNSTLGPSEEQEKNWPGGPGRLGHWLPAAPGRLEKLEGLLANVSRELGGRMDLLEEQVAGAVRTCGQICSGAPGEQDSRVNEILSALERRVLDSEGRLQLVGSGLHEAEAAGEAQQAVLEGLQGLLSRLRERMDAQEETAAEILLRLNLTAAQLSQLEGLLQARGDEGCGACGGVQEELGRLRDGVERCSCPLLPPRGPGAGPGVGGPSRGPLDGFSVFGGSSGSALQALQGELSEVILTFSSLNDSLHELQTTVEGQGADLADLGATKDSIISEINRLQQEATEHVTESEERFRGLEEGQAQAGQCPSLEGRLGRLEGVCERLDTVAGGLQGLREGLSRHVAGLWAAVRESNSTSLTQAALLEKLLGGQAGLGRRLGALNNSLLLLEDRLQQLSLKDFTGPSGKAGPPGPPGLQGPSGPAGPPGPPGKDGQQGAIGPPGPQGEQGAEGAPAAPVPRVAFSAALSLPRSEPGTVPFDRVLLNDGGYYDPETGVFTAPLAGRYLLSAVLTGHRHEKVEAVLSRSNLGVARIDSGGYEPEGLENKPVAESQPSPGALGVFSLILPLQVGDTVCIDLVMGQLAHSEEPLTIFSGALLYEDTELEQV