wanglab/gogpt-training-data huggingface dataset:
Protein: Eyes absent homolog (EC 3.1.3.48) (A6NCB9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEMQDLTSPHSRLSGSSESPSGPKLGNSHINSNSMTPNGTEVKTEPMSSSETASTTADGSLNNFSGSAIGSSSFSPRPTHQFSPPQIYPSKPYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGIKTEGGLSQSQSPGQTGFLSYGTSFSTPQPGQAPYSYQMQGSSFTTSSGIYTGNNSLTNSSGFNSSQQDYPSYPSFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGITSQAVTDPTAEYSTIHSPSTPIKDSDSDRLRRGSDGKSRGRGRRNNNPSPPPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRISSHSDLMALHHALELEYL
Protein: Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic (GSA 2) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase 2) (GSA-AT 2) (Q42522)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:25840087}.
Interaction partners:
- Glutamyl-tRNA reductase 1, chloroplastic
- Glutamyl-tRNA reductase 2, chloroplastic
- Probable delta-aminolevulinic acid dehydratase 2, chloroplastic
- Probable glutamyl-tRNA reductase 3, chloroplastic
- Delta-aminolevulinic acid dehydratase 1, chloroplastic
- Porphobilinogen deaminase, chloroplastic
- Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
- Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic
- Argininosuccinate lyase, chloroplastic
- Coproporphyrinogen-III oxidase 1, chloroplastic
Sequence:
MAATLTGSGIALGFSCSAKFSKRASSSSNRRCIKMSVSVEEKTKKFTLQKSEEAFNAAKNLMPGGVNSPVRAFKSVGGQPVVMDSAKGSRIRDIDGNEYIDYVGSWGPAIIGHADDEVLAALAETMKKGTSFGAPCLLENVLAEMVISAVPSIEMVRFVNSGTEACMGVLRLARAFTGKQKFIKFEGCYHGHANSFLVKAGSGVATLGLPDSPGVPKAATSDTLTAPYNDIAAVEKLFEANKGEIAAIILEPVVGNSGFITPKPEFIEGIRRITKDNGALLIFDEVMTGFRLAYGGAQEYFGITPDLTTLGKIIGGGLPVGAYGGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLSQPGTYEYLDKITKELTNGILEAGKKTGHAMCGGYISGMFGFFFTEGPVYDFSDAKKSDTEKFGKFFRGMLEEGVYLAPSQFEAGFTSLAHTSEDIQFTIAAAEKVLSRL
Protein: Tryparedoxin peroxidase (Q38EX8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Glutathione peroxidase
- Glutathione peroxidase
- Glutathione peroxidase
- Nucleoside diphosphate kinase-like domain-containing protein
- Ribonucleoside-diphosphate reductase small chain
- Ribonucleoside-diphosphate reductase small chain
- Ribonucleoside-diphosphate reductase small chain
- Ribonucleoside-diphosphate reductase small chain
- Ribonucleoside-diphosphate reductase
- Trypanothione synthetase, putative
Sequence:
MSCGDAKLNHPAPHFNEVALMPNGTFKKVDLASYRGKWVVLFFYPLDFTFVCPTEICQFSDRVKEFNDVDCEVIACSMDSEFSHLAWTNVERKKGGLGTMNIPILADKTKSIMKAYGVLKEEDGVAYRGLFIIDPQQNLRQITINDLPVGRNVDETLRLVKAFQFVEKHGEVCPANWKPGSKTMKADPNGSQDYFSSMN
Protein: Protein Dr1 homolog (Negative cofactor 2-beta homolog) (NC2-beta homolog) (P49592)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA polymerase II subunit B4
- At3g12480/MQC3.32
- Histone superfamily protein
- TATA-binding protein-associated factor BTAF1
- TATA-box-binding protein 2
- TATA-box-binding protein 1
- AGAMOUS-like 98
- Pleckstrin homology
- DExH-box ATP-dependent RNA helicase DExH14
- DNA-binding protein S1FA1
Sequence:
MDPMDIVGKSKEDASLPKATMTKIIKEMLPPDVRVARDAQDLLIECCVEFINLVSSESNDVCNKEDKRTIAPEHVLKALQVLGFGEYIEEVYAAYEQHKYETMQDTQRSVKWNPGAQMTEEEAAAEQQRMFAEARARMNGGVSVPQPEHPETDQRSPQS
Protein: Zinc finger protein 516 (Q7TSH3)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:25578880}.
Interaction partners:
- Histone-lysine N-methyltransferase PRDM16
- Lysine-specific histone demethylase 1A
- C-terminal-binding protein 1
- Transcription factor COE2
Sequence:
MDRSREAEMELRRGPSPPRAGRSHEVDGDKAACHSCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEAQLGEMRVSEGLDGCASPTKSTSACNRVLNGAVPMDGSKILLRSSRKEVEGAASAQEDTEATVPCSFCKSRFERKKDLELHVHQAHKPFKCRLCSYVTLREESLLSHIERDHITAQVPNGSEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGPKAGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCTKCGNLFTNLDSLNAHNAIHRKVEASRIRAPAEEGDSEDPLDTKQFFLQCLNLTPYVAGDVSPGGQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGTWDEALAGDVAFDKDKREYILVSQEKRKREQDAPATQAPPRKRASVPGDPMLSGHLDPRPTSRPNRRASATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRDRDPEGDRAARARCGSLSEGDSASQPSSPGSACAIADSPGLAEEVVDDSGEEAVPEPASGGQPRHCCSSGEVTPTALSNGDQNHKLGNNLPEKDISEPKVGSAMPSVSILENSSRETTKGPEQHRYSLDLKMPAFHPKQEVPSTTDRVDFPASMEITSLQHTLDSQAGHSKEKLSDLHKEHCGVGKRASAPDLVPLDLSMRSSRDEPSGKEACSLQAALVIHPCPYCTHKTYYPEVLWMHKRIWHRVSCSSVAPPWTQPSGHKSIRSNLVFLTRSGRTGPPPALGGKECQPLLLSRFARTQVPGGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPCALWASGPDGYRQTRAGHGQEPPSAAVQGPLAKPKQEGSSRLAPSPGSGSLSRSTTPTPSVITRVGAQPSANSKPVEKLGGPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEPAAEGQEKRLDILSIFKTYIPKDFATLYQGWGVSSPGPEHRGTSLTGTPRTQAHQGDFVCVECGKSFHQPSQLRAHLRAHTVVFECDGPRDSEVHTASTDAPKQGRDHTTPGTVPAGPLRKGI
Protein: Riboflavin synthase (RS) (EC 2.5.1.9) (P38145)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Interaction partners:
- 6,7-dimethyl-8-ribityllumazine synthase
- GTP cyclohydrolase-2
- 3,4-dihydroxy-2-butanone 4-phosphate synthase
- Riboflavin kinase
- 2,5-diamino-6-ribosylamino-4
- Bifunctional protein RIB2
- Low molecular weight phosphotyrosine protein phosphatase
- Acid phosphatase PHO12
- Acid phosphatase PHO11
- Constitutive acid phosphatase
Sequence:
MFTGIVECMGTVLENNPYDDSESGGQGVSITIGNAGSILTDCHVGDSIAVNGVCLTVTEFNNDSFKVGISPETIKRSNVASWIQGTQVNLERAVSQDVRFGGHYVQGHVDTVANIVSRRPEGNSIIFGFQLRDQEYFKYIVEKGFICIDGTSLTIIKVDPLSQGGAFYISMIKHTQDNVIMPLKKIGDEVNIEVDLTGKIIEKQILLTLENQISKKDSTLNTMISNIIEEKVRNYLNK
Protein: DUF3456 domain-containing protein (Q38A59)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGKAPVKGVFLVLVALVPMFPAVDAKKEKPMNVPFPQDAIDDVRCDVCRLMAKRAYGYVYELFVTSEHTRIPVNEENVLVAIEDICNPLAASGQWIRQVAVDTSSPAAAKGPFHITLTELPHHSKCKRTCKTLSDACEAVVDDDDMDQFSSKLLILKKYKDASALADATCGVSAFCTSRTGFSSKRYKELLTLVASDVVEVIEQKEMDIERFMDEMERKGNRRQEIYSREEVIKMQKSLIEGDIETAAGIDPSLNKLTEEEQLALQQMLKNKPMGKKRPPEDAGQAASPEGDSAEVNPDL
Protein: Histone deacetylase (EC 3.5.1.98) (A0A8I5ZWP6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037911}.
Interaction partners:
Sequence:
MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDTKDDFPLRKTESSVSSSSPGSGPSSPNNGPAGNVTENEASVLPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLSASNSLKDKQKCETQMLRQGVPLPGQYGSGIAASSSHAHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMEERATSKDSGTGKDSSACVEDTLGQVGAVKVKEEPVDSDEDAQMQEMECGEQAAFMQQTPLLESSHTRALSVHQARLAAAGIDGLEKHGLLSRTHSSPAPSMSPHPAADCPRQPASATGIAYDCLMLKHQCICGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTSPLDGQKLDPRTLLGDDSRKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGVGLGEGYNVNIAWTGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLANGRVALALEGGHDLTAICDASEACINALLGNEPGSLEEDVLHQSVNTNAAASLQKTIEIQSKYWKSIKMVAVARGCALPASQLQEETETVSALASLTVDVEQPFAQEDGRTAGEPMEEEPAL
Protein: Cysteine proteinase 1, mitochondrial (EC 3.4.22.40) (Q6FP08)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Mitochondrion {ECO:0000256|PIRNR:PIRNR005700}. Cytoplasm {ECO:0000256|PIRNR:PIRNR005700}.
Interaction partners:
Sequence:
MYRLRSLIRPIRKYSMSRSLAIDEIASWDKELSKDLHHQLATTVLKNINADDALLNKTRLQEQDVRVFNTKLSVDCTPVTNQRASGRCWLFAATNHLRVNVVKELQLKDFELSQAYLFFYDKLEKANYFLDQITQSHEEPVDSRLVQYLLTDPTQDGGQYSMFLNIVKKYGLIPKDLYNDAAYSTTASRKWNSILTSKLREFAETIRETLKTKDVESKEFKELRTSMQKEIFRLMTLFMDLPPVKPDEKFTWTYQDKDKKVHTIESTPLEFASKYAKLDAAKPVSLINDPRNPYGKLIKIDRLGNVIGGEETLYLNVDNKTLTDLIVKRLKNDKPVFFGSHTPKYMDKKTGVMDIDLWNYHAIKYDLKQSKASRIEYHESLMTHAMLITAAHVDDDGNPVRFCVENSWGKDSGKDGMYVMTPEYFEEYCYQIVVDIDELPTDLAEKFDDKEPIVLPIWDPMGALAE
Protein: PR domain zinc finger protein 13 (PR domain-containing 13) (F1R7D7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- T cell leukemia homeobox 3b.
- Pancreas transcription factor 1 subunit alpha
- Homeobox protein engrailed-like
- PR domain zinc finger protein 2
Sequence:
MQTTRTPTISVYADCSIPAGLRIGPVPGIFKLGKYVSDRKELGVKKKIRLVRGEFVDESGSAVPDWIGLIRAARNGQEQNLEAVSDLPGGQIFYRVVREIQAGEELSVWYSNSLAQWFDIPTTATPTHDEKGEERYICWYCWRIFKYPNTLKAHVHFHCALSNGRSLVSNEQVRGTDNFNRSPKSGDIPNTSTSPRNGHSTFMSDAVKRVASTSPFANKAKKPTAEEQDRALDMSVTSARNPGHILGLGGTPSVLNSMGFHPGVRSAFKPMGLAKISPAEVPRDEHNVKPNSIGFSKLLGNIKSVRGLNETLPSVHPSKCAHPMDSTPPVIPCANAIRGFPLLPHFEETSAFKHVDSRVHPALSPSRYSQLPAGFHFERFSLPQFDGGKSYNGDCNIPIMPFTVYNGELLYSSPYYPLKFHFGNLLKYPDYFGAPALNPDLNSITNIDREIAMHTQQLSEIAVEKNRSRLDSLPASNPNSGKPKKGHLCLYCGKLYSRKYGLKIHMRTHTGYKPLKCKVCFRPFGDPSNLNKHIRLHAEGNTPYRCEFCGKVLVRRRDLERHVKSRHPGQSIKKSDVKMEGMFEDGEQKSDNDSDVDVCFTDDQSDQESSKNND
Protein: ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD antigen CD275) (Q9JHJ8)
Organism: Mus musculus (Mouse)
Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10549624, ECO:0000269|PubMed:10657606}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11390480}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11390480}.
Interaction partners:
- Inducible T-cell costimulator
- Cytotoxic T-lymphocyte protein 4
- Tumor necrosis factor receptor superfamily member 4
- T-cell-specific surface glycoprotein CD28
- CD40 ligand
- Tumor necrosis factor receptor superfamily member 5
- CD27 antigen
- T-lymphocyte activation antigen CD80
- Programmed cell death protein 1
- Tumor necrosis factor receptor superfamily member 9
Sequence:
MQLKCPCFVSLGTRQPVWKKLHVSSGFFSGLGLFLLLLSSLCAASAETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRVAANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTGNNTKNPQETHNNELKVLVPVLAVLAAAAFVSFIIYRRTRPHRSYTGPKTVQLELTDHA
Protein: WD repeat domain 62, isoform C (Q0E8U7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFAPRNSSPVAIYGKEDVAAYEIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPKRHSVYADDARTILDMIHADTEKMIDEITRKYGDLDEPGIPASYSMPANLRNLGGLGSTGDSTPTGRTTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLESVLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFIIHGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSFDVTGYNLEPLKPLPSSKTYPRIAQVQASENIPTLRSKNKQYTSGVNKSLSTDFAQQRQQRNSNPMQSGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQKQKSQSRTASVVQQFEHNLQKFEKEKQREREQQRRPAMRSSVSSGALAGGSTTQSCLKKVSRFDTSESSRRATSVRQKNRPKISVRFNTVSQIKYTPSAKRERQAREEEPPEMEVGSLPSDYGERSFEMYFAENGNAPENLENMQTLKLYTKPQLQAVVDEIQQEREKYRKNLDNAGKISGKGGSGKGKGAGSSTSHQCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLRPFNCNAKEKGYVKSLTMNFDMLARGEDPTEDEDLASKDASDLCAYARNIRRNCSLPDVLESTDFTGIYNSQGVELAKEVIADDESGDPVNPGITADSADHDGIGQTVVLRMEPGNPKTLNPMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQHRNGNVSRSASKRNSLQGKTGLGASSNSMNVLNQGSDSEPEDSNRLRSASNGQGRSNGPIAANRQYSNKINNVNNNRRKTPNFSSATPMQDDSSSEETPNSTVNNKPIVPPRPRNLAFDHKSKLMINNSGSPGGNAKQRSGVTSTEDFEGTDPEAQVHNVINKLYTTTQAAMQLHANLKNTLLLKELENALIMSRNMLSSITNRQADKTNNGGGGLGVGGSGGLNHDQLNADNGDYLMMVNNCADLLSNLRTKHKPDDCENNS
Protein: Golgi apparatus membrane protein TVP23 (TLG2 compartment vesicle protein of 23 kDa) (P38962)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Golgi membrane protein involved in vesicular trafficking.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16107716, ECO:0000269|PubMed:17178117}; Multi-pass membrane protein {ECO:0000269|PubMed:16107716, ECO:0000269|PubMed:17178117}.
Interaction partners:
- Autophagy-related protein 17
- Serine/threonine-protein kinase ATG1
- Protein YIP4
- Golgi apparatus membrane protein TVP15
- Protein YIP5
- Golgi apparatus membrane protein TVP18
- Golgi apparatus membrane protein TVP38
- Protein SVP26
- Uncharacterized membrane protein YDR090C
Sequence:
MDQARNFYNTILKSSHPLLLSFHLAGKAVPIVFYIIGSMFLNFTPQFITVVLLLSFDFYLTKNITGRKLVQLRWWYDSTDVNKDSNFTFESYKQYAPGPPINAIDSKLFWWSMYVTPVIWGVFAVLCLLRLKIFYLILVIVAMCLTAWNTYGFRCCDRWEPNSGQSDGQDTNNWFALPSVPGFENLSRLANIQSFFQRQ
Protein: Mas-related G-protein coupled receptor member F (Mas-related gene F protein) (G-protein coupled receptor RTA) (P23749)
Organism: Rattus norvegicus (Rat)
Function: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAGNCSWEAHSTNQNKMCPGMSEALELYSRGFLTIEQIATLPPPAVTNYIFLLLCLCGLVGNGLVLWFFGFSIKRTPFSIYFLHLASADGIYLFSKAVIALLNMGTFLGSFPDYVRRVSRIVGLCTFFAGVSLLPAISIERCVSVIFPMWYWRRRPKRLSAGVCALLWLLSFLVTSIHNYFCMFLGHEASGTACLNMDISLGILLFFLFCPLMVLPCLALILHVECRARRRQRSAKLNHVVLAIVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAEPGDAASSTPNTVTMEMQCPSGNAS
Protein: A disintegrin and metallopeptidase domain 6 (B2RSY5)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MLSLTWGMRLVERPVVPRVLLLLFALWLLLLVPVWCSQGHPTWRYISSEVVIPRKEIYHTKGLQAQRLLSYSLRFRGQRHIIHLRRKTLIWPRHLLLTTQDDQGALQMEYPFFPVDCYYIGYLEGILQSMVTVDTCYGGLSGVIKLDNLTYEIKPLNDSQSFEHLVSQIVSESDDTGPMNAWKHWSHNTGSPSSRLEYADGAPRLSSKNYATHPAAIKGHFQATHSVYSASGGDKLSSTVEYLFKVISLMDTYLTNLHMRYYVFLMTVYTEADPFSQDFRVPGGQAHTFYERVFYAHFRPDAGAIINKNSPGDDAVNPAERSICSPSALICLGQHGRNPLFLSIIITNRVGRSLGLKHDEGYCICQRRNTCIMFKNPQLTDAFSNCSLAEISNILNTPDLMPCLFYDRHVYYNTSLTYKFCGNFKVDNNEQCDCGSQKACYSDPCCGNDCRLTPGSICDKELCCANCTYSPSGTLCRPIQNICDLPEYCSGSKFICPDDTYLQDGTPCSEEGYCYKGNCTDRNIQCMEIFGVSAKNANIKCYDINKQRFRFGHCTRAEESLTFNACADQDKLCGRLQCTNVTNLPFLQEHVSFHQSVISGVTCFGLDEHRGTETADAGLVRHGTPCSRGKFCDRGACNGSLSRLGYDCTPEKCNFRGVCNNRRNCHCHFGWSPPKCKEEGHSGSIDSGSPPVQRRIIKQNLEPVVYLRILFGRIYFLFVALLFGIATRVGVTKIFRFEDLQAALRSWQEQAKDK
Protein: FH2 domain-containing protein 1 (Inverted formin-1) (Q3ULZ2)
Organism: Mus musculus (Mouse)
Function: Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation. Regulates Golgi ribbon formation. Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:26564798}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9C0D6}. Note=Associates with microtubules. {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}.
Interaction partners:
- Profilin-4
Sequence:
MHVMNCVSLASDKENGTLATAAAFMTGQTSPSASPPPPPPPPPPPPCPHSGEGFSPSPPPPLPPPLPGGPPIPPPPPPGLPSVSYLNGYSSLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLADSFLHCLIQVPNYSLRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFSEKLQHVQETSRLSLDITEAELHSLFVRTKSLQENIQLDQELCQQMEDFLQFAVEKLAELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRYSWSTGELGSFGRSSSENDVQMLAKTGTEDLPSFLKPRPNSPSYRPPNTRRSRLSLGISADRELLTFLESATSSPEDPNKFNSLPRSSPRQARPTIAWMEPREQQSHGPNFTHEPQASKIQEKAPPPAWQNQLPTTWREEPASPLPLAGRSRPSLRKRNSEPVGLGPTQSPPLLPLDLGVREHELVTGLTQFDLQSPKSLEEGSQLTLNDFCPTKLPSPGDRSSQPFAAGGDSLPPKDTDTQEVLSPAGEDDRTISDEPSSEALVSVVVTDTEDKDAGPLLYVSDTTDCSLTLDCSEGMDSRAGGDKQEEEKEGDGSVSSGAGEAGSSQVSSNSVSSPPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRNSFKEASVGASKPVSARRSQGVTTKPVRTLNSSENEHMRKVVPISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPQVSGSGAEEPRLPRSSGSISGRPGKDAPLQPRASFRKPSAKPLRNIPRQKPEENKVSSPNSPDPESPKEEPKAPQATGVSRALPPIPSFARNTVASSSRSLRTDAPPAARTTGLTRTVSQRQLRVKGGSEDSASKDIGTLKRASSARASKKCPESAGGSSANVETSLKGRGTTERSSLRLKDSGQATLGRILRPLQK
Protein: Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Q9JMA1)
Organism: Mus musculus (Mouse)
Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (By similarity). Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome regulatory subunit 6B
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit 8
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKMKNGMTVLMMGSADALPEEPSAKTVFVEDMTEEQLATAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSGRETDSSSAPAVTPSKKKSLIDQYFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNANDKNSPPKEIKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVRRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
Protein: Zinc finger protein 608 (Q56A10)
Organism: Mus musculus (Mouse)
Function: Transcription factor, which represses ZNF609 transcription.
Interaction partners:
Sequence:
MSVNVSTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTNTTTNTTKDCGGPASNGTCSTSALADGLKFASVQPSAPQGNSHKETSKSKVKRAKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSGGGSSNPNSNGTSTGTSAATAGAGSCGKSKEEKPGKSHSSRGAKRDKDAARSRKEKHDLLQGHQNGGGGQAPSGGHLYGFGTKSNGSGASPFHCGGAGSGSVGAAGEVSKTAPDSTLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPIASSLAPQIPPSYFPPSSSNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGRGKRARSAAAAPGSEVSFTESRGLQSKNRGGANGKGRRGSLNASGRRTPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDSKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEALSNVALECNESSTSVSSYDQTKAPGSPGAGNPPGTPKGKREHVSNGPGPIIGSKTGKNSGKKRGLNNELNNLPVISNMTAALDICSATDSNLTAEMPKLEAEGLIDKKSLGDKEKGKKANNCKMDKNLSKLKSARPIAPAPAPTPPQLIAIPTAAFTSTTTGTIPGLPSLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSLKDRKKKEKRKLKDKEGKETGGPKMDAKLGKLEEAKAASKDLSGHFLKDHLGKSEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRMECSTLVNGQAPMAPLHVLTQNGAESAAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDTFSNKDGVVKGHPSTSAQPSQLKESHSPYYHGYEPYYSPSYMHPGQVGAPAAGNGGSTQGMKIKKESEEDAEKKDKAEQLESKKVDHTSAPLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQSGRGDCERKAELPLKELGKEDNKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSSHQQQLQADSFKAKQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPESRTWHHYVYQPKYLDQQKPEELDREKKLKEDSPRKTPNKESGVSSLPVSLTNIKEEPKEGKRPDSQSVEENKLKNDDRKTPVNWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSPGFHYPVYGKMSGREEAEKVNTSPSINTKTASEAKALDLLQHHANQYRSKSPAPVEKASTEREREAERERDRHSPFSQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQASASGMFPAQRRE
Protein: Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) (Q9BT09)
Organism: Homo sapiens (Human)
Function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Endoplasmin
- Lymphocyte antigen 96
- Protein unc-93 homolog B1
- Leucine-rich repeat-containing protein 40
- Toll-like receptor 4
- Toll-like receptor 9
- Toll-like receptor 8
- Toll-like receptor 1
Sequence:
MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL