wanglab/gogpt-training-data huggingface dataset:
Protein: (S)-8-oxocitronellyl enol synthase CYC1 (EC 1.3.1.122) (Cyclase 1) (Iridoid synthase) (ISY) (A0A1C9CX56)
Organism: Camptotheca acuminata (Happy tree)
Function: Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate. Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities.
Interaction partners:
Sequence:
MSWWWARSLGAQKEFKENGALTSYQSVGLIIGVTGIVGNSLAEILPLPDTPGGPWKVYGVARRPRPAWNTDHPIEYIQCDVASTEDTLAKLSPLTNITHIFYVAWTGSEDCEVNETMFHNVLKAVIPNAPNLRHICIQTGIKHYTGPLDPDGGIQPHDSPFTEDLPRLNAPNFYHNLEDILIEEAAKKKGLTWSVHRPALVFGFSPYSMMNIIGALSVYAVICKHENKPLIYHGAPDNSRDSWNVYADAADADLIAEHQIWAAVDSNAKNEVFNCSNGDVFKWKQMWKILAEQFEVELVGYEDGQKRMSLQERMKGKGPVWDEIVRKHKLLPTKLEDVAQWWFADIVSQSQNLVNGVNKSKENGFLGFRDSKKSFVYWIKKMRAAKIIP
Protein: Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glutathione-binding 13 kDa protein) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) (P30904)
Organism: Rattus norvegicus (Rat)
Function: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P14174}. Cytoplasm {ECO:0000250|UniProtKB:P14174}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000250|UniProtKB:P14174}.
Interaction partners:
- H-2 class II histocompatibility antigen gamma chain
- C-X-C chemokine receptor type 2
- Aspartate aminotransferase, mitochondrial
- C-X-C chemokine receptor type 4
- Tyrosine aminotransferase
- Aspartate aminotransferase, cytoplasmic
- 4-hydroxyphenylpyruvate dioxygenase
- Amine oxidase.
- Amine oxidase
- Amine oxidase
Sequence:
MPMFIVNTNVPRASVPEGFLSELTQQLAQATGKPAQYIAVHVVPDQLMTFSGTSDPCALCSLHSIGKIGGAQNRNYSKLLCGLLSDRLHISPDRVYINYYDMNAANVGWNGSTFA
Protein: ABC transporter C family member 14 (ABC transporter ABCC.14) (Q54K24)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter G family member 15
Sequence:
MFINSFETKIKKKFSLLYEKLDDEDENEPSSSPSNSTNNFYKACPEDNSSKWSKISFNWVTKLIMKGYFKESLEMNDIYDLPELNKVQTTSKLLDDINFSNGSKYALIKHIYKNFLPKNKYALISNIFITIFIFLSPICLKFLINYISTDNDNEKSILKGILLCCLLCISILGQSISQELFYWFGMKNSFDVRGALTAKIFEKTLKLSNVSKKKYRSGKIMNIMSIDVENISEFFWTYYLDIVSHTLQILILLGLLCYVVGPSGLVGFGVMVIALPINTMLCTKSSNYLEKSLEYSDSRTNLTSELITNIRPFKMYAWENLFINKIEEQRKQELKFLFLRVLFWIFDHMMIETNATLVLVSTFATYSLTGNTMSLDVTFTAMTIFANLKLPLIYLPEDIYKAIGLMPSVKRIQNFLKSSESLKSKENNQNINFNNNNNNNNNNKNNNNNDDNDIIIENCTFQWNEPENNNLFEFNQSEDEEENEEEEEEENEENIKINENFDYKLNDINLIVPKGKLTMICGVVGSGKTSLVCGLIGEIYKLNGSVSGVPNNISFTSQQPFLLSASLRENILFGNEFDIERYKKVIESTALTKDIVNLAGLDLTEIGERGINLSGGQKQRISLARALYANSDCFIFDEPLSAVDPEVASHLFDHCIQGIDFKSILKTKEIKKNVENETDSEELIKNEIEIENEIIDVNNVISDKNDPNLIEKAKLLVKEDKNEGEVEFNVYKKYFSYGTSGVTLFITISLFFIGQAVYKVSDFWLAIWTERSIEGKSDSFYIGYYLLIIGIFVSLLMIRTYSLSRITFGIGKNLHSALLKSVTYASCRFFDTNPSGRILNRFSKDTSDIDIHMLDLLSEVSICFSELTIGLISIVFIIPIIIIPLTLLFIIYYIYQRLYRPSARELNRWESITLSPVFSLLQECYNGLLTIRTYKQESRFIKEMFDNININLGCIFYSFAVHRWISMRLEVMGCIMVFFTSLAAALFTSNNGLAALSVTTALSLNGYLSWGVRRIVELEVKMNSFQRIQSYIEIPKEGNKLISTGTNQVDSDGLKTISNGDLVNWPNKGIIEFKNVEIKYRPNSEPNLKDLSFKVQSSEKIGIVGRTGAGKTTIASSLFRMVECSKGLILIDGIDISKVQLQKLRSSIGIVPQDPFIFTGTIRSNIDPFNEFTDFEIWESIEKVKLKDAINSMPLKLETALQENGDNGFSYGQKQLLCLCRTILKNFKIILMDEATSSIDYHTAQLIKQTIQENFKDCTTLTIAHRLETIIDCNKIAVIDSGQLIEFDTPSNLMNIPNSKFNKLIKSQTDYSNNKIK
Protein: BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein homolog) (Ruby-eye protein) (Ru) (Q8BLY7)
Organism: Mus musculus (Mouse)
Function: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (By similarity). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning.
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:Q86YV9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q86YV9}. Early endosome membrane {ECO:0000250|UniProtKB:Q86YV9}. Lysosome membrane {ECO:0000250|UniProtKB:Q86YV9}.
Interaction partners:
- BLOC-2 complex member HPS3
- BLOC-2 complex member HPS5
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- BLOC-3 complex member HPS4
- Dysbindin
- BLOC-3 complex member HPS1
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 5
Sequence:
MKRAGTLRLLSDLSNFTGAARLRELLAGDPAVLVRCSPDGRHLLLLRPPGSPAPQLLVAVRGPGLPLERAWPEGDPSPLDVFFVPWLARPALILVWESGLAEVWGVGMEPGWKLLQSTELCPDGGARVMAVAATRGRLVWCEERQPGVKDQPEQLSTAFSHRVCFKTLETSGEAGTKLGCTHILLHHCPLFGLIASRKDLFLVPTTNTWSGVAHLLLIWSPSKGKVIVAAPSLGLSHSKSLNPKQGDTWDFRTLLRGLPGFLSPREPLAVHTWAPSSQGLLLLDLKGKVSLVQCHGGTRTVGILQEAPVSLKGSAALGTFHGTLACVLGSTLELLDMSSGRLLEKKVLSTDRVHLLEPPAPGMKNEEELETRGALRLLSALGLFCVCWETPQGLELPSDKDLVFEEACGYYQRRSLRGTQLTPEELRHNSMFRAPQALASILQGHLPPSTLLTTLRAELRDYRSIEQLKAQLVAGDDEEAGWTELAEHEVARLLRTQLTGDQLAQFNTIFQALPTAAWGATLQALQLQPDRSGRLRSQAPPDVWKKVLRAPTAGKEHPNGILPPFELLCQCLGQLEPQWLPPFVKLAQQQGGPGWGAEGPSLPLYRRALAVLGEEGKRPEALELELLLGSGRPKAVLQAVRQLIKKEEWERALEAGLALDASSPLLRSEIFKLLLAEFAQHRRLDAHLPLLCRLCPPEVAPHELLLLLRTHLPDDEGTTPFPEPGAEPPLTVGLVRALLEQTGAQGRPSGPVQSTYEDILWDPGTPPPTPPRGPTASLPASDHPGQEAWVPPGQGLGAADVGVHL
Protein: Protein S100-Z (S100 calcium-binding protein Z) (Q8WXG8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQDLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK
Protein: Pyoverdine biosynthesis protein PvdE (Q9I183)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Pyoverdine synthetase D
- PvdL
- PvdJ
- phosphoribosylglycinamide formyltransferase 1
- L-ornithine N
- Ferripyoverdine receptor
- Probable non-ribosomal peptide synthetase
- PvdG
- Acyl-homoserine lactone acylase PvdQ
- PvdP
Sequence:
MTNPKRGAIRELLALLRPFRAIVAVSIALGMAGGLAITLLLASINNALHSENGLGQGVLLSFGGLCLLALVSSIVSDIGTSYVGQHIIAKLRKELGEKVLSAPIEQIERYRTHRLIPVLTHDIDTISDFSFSFTPLAIALTITFGCLGYLAYLSVPMFLLTVVAIVIGTAAQYLARSRGFKGFYAARDLEDELQKHYTAIASGAKELRIHRPRRYRMHTGRISETANNIRDLHISSINIFILAKTFGSMLFFVVIGLALTLQAYWPSSNPAAITGFVMVLLYMKGPLEQVVTILPIVSRAQVAFQRVAELSERFSSPEPHLLLSEQEAPDKTVDSLELRDVRYSPPAVEGSEPFHLGPINLRIAQGDIVFIVGENGCGKTTLIKLLLGLYRPQSGEILLNGEPVSAETRDDYRQLFSTIFADYYLFDDLVQGKQASLQNATQYLQRLEIAHKVSVMDGNFSTTDLSTGQRKRLALINAWLEERPVLVFDEWAADQDPAFRRVFYTELLPDLKRQGKTIIVISHDDRYFEMADQLIRLSAGKVVKETETA
Protein: Cytochrome P450 monooxygenase otaC (EC 1.14.14.-) (Ochratoxin A biosynthesis cluster protein C) (A0A1R3RGJ7)
Organism: Aspergillus carbonarius (strain ITEM 5010)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of ochratoxin A (OTA), a mycotoxin composed of a chlorinated type I polyketide dihydroisocoumarin moiety linked to L-phenylalanine, and demonstrated to have nephrotoxic, immunotoxic, genotoxic, neurotoxic, and teratogenic properties. OtaC catalyzes the oxidation of 7-methylmellein (7-MM) into 7-carboxymellein. The pathway begins with the highly reducing polyketide synthase otaA that catalyzes the formation of the isocoumarin group during the initial stages of biosynthesis, starting from one acetate and 4 malonate units, to originate the characteristic pentaketide skeleton 7-methylmellein (7-MM) of the OTA molecule. The newly identified cyclase otaY might be involved in the polyketide cyclization reaction during the initial steps of the OTA biosynthesis. 7-MM is then oxidized into 7-carboxymellein (also called ochratoxin beta) by the cytochrome P450 monooxygenase otaC. The NRPS encoded by the otaB gene is involved in the linking of phenylalanine to the dihydroisocoumarin ring. The reaction catalyzed by NRPS results in the production of ochratoxin B (OTB), which is the non-chlorinated analog of OTA and which subsequently serves as the substrate of the halogenase otaD for chlorination activity to form the final molecular structure of OTA, containing a chlorine atom in the C-5 position of the molecule (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Highly reducing polyketide synthase otaA
- Nitrate reductase
- FAD-binding FR-type domain-containing protein
Sequence:
MNMDSIASFSHPFLWTAFAVGVVYCCTRMVSELFLSPLSHIPGPKLAACTRLYEFFYDVICHGRYTFKIAELHEKYGPIVRISPTEIHINDPEFYETLYSTSAPRNKDPWFTTNFDVAESAFSTLDYRLHRPRRALIAPYFAKARVDRIQPLIQGKITKLMRQLDEYARAGKPLKVDVAYNCFTADVITGYTSYRPLGYLDTPDMVPIWSETVRNLVEIGMIARHLPGFFPLLASTGARCIQMVYPKLLSVIAFRVKCIQEVNFMWTHPETATKDAAQAECSEPALFPELVSRASTTPDITEERVLHEFITIVAAGTETTAHTMTVCTFHILNNKDILRRLRAELNDKFPGDATMDLQTLEQLPYLTGIIYEGLRLSYGLSHRLQRISPTDPLKYKDVVIPPNTPVGMSSALIHHDETIFPQSHAFIPDRWTDINERRRLNKYMVAFSKGSRQCIGMNLAFAELYMAVAALFRKYDMELQDTTVDDVKLHSDMMLPHAKKGSKGVRVILKPAQGGE
Protein: Ribosomal protein S6 kinase C1 (A0A087X1U5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
Protein: Pyruvate dehydrogenase E1 component subunit alpha (EC 1.2.4.1) (Q7KVX1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- dihydrolipoyllysine-residue acetyltransferase
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Dihydrolipoyl dehydrogenase
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- [Pyruvate dehydrogenase
- ATP synthase subunit alpha, mitochondrial
- Malate dehydrogenase, mitochondrial
- Probable citrate synthase, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- ATP synthase subunit gamma, mitochondrial
Sequence:
MLRTLSRVSELPIIVKQLQKRCHNNNNNNIIISGCRILSNNNNNSSIDIIRNGRYSSSFFGLFQNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRGTIAYDIDHIQERKGVNH
Protein: Karyogamy meiotic segregation protein 2 (O43087)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Note=Associates with the spindle pole body (SPB).
Interaction partners:
- Spindle pole body-associated protein sad1
- Karyogamy meiotic segregation protein 1
- ADP,ATP carrier protein
- Integral inner nuclear membrane protein ima1
- Telomere bouquet protein 2
- Nuclear envelope protein ndc1
- Telomere bouquet protein 1
Sequence:
MDEYIPFDDIVRQYDPDYTGKVSIQAFLEIVDDVDALRLNPEAPLLDNEQRQSAQDFIKDNSEIVVSTSEIKNLFYELTGLDPDTLPVNKLALRENGVLPRKSVAKPQKISENRIKRKDMFYQDASYITPRKGSPLSHSTPLSMFRTKNEYGSNKGFSHINKENADDSLIQQLYERIELQAAELRSKDEQVKELNARNAKLLEELDSSEEACKSCYTQAKTWEKKFREALRDSKEYAAQLQTIHEEYEQQQAHIVRMEELIHAVEKERKTETDYMKKESLSEQKERGAFMESNMILEEKVAHLQLENEQLRLFFKEKAPQPFQNHPPYQNLKITFPSPFFHIPYIPKTETLNDSQFAAGLSLLASELESQKNLLKKFENLKKKSSKDFLSPSTILSNAFSKVSLPNSLILRVLFFSLLFIIGIHIFYFLFFHVATIQQWPFLFWLPSTKFDNRWSPT
Protein: Biglycan (Bone/cartilage proteoglycan I) (PG-S1) (P21810)
Organism: Homo sapiens (Human)
Function: May be involved in collagen fiber assembly.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Fibronectin
- Toll-like receptor 4
- Elastin
- Decorin
- Toll-like receptor 2
- Transforming growth factor beta-1 proprotein
- Fibromodulin
- Collagen alpha-1
- CCN family member 4
Sequence:
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK
Protein: U17-myrmicitoxin-Tb1f (U17-MYRTX-Tb1f) (A0A6M6R9M4)
Organism: Tetramorium bicarinatum (Tramp ant)
Subcellular location: Secreted {ECO:0000269|PubMed:30149710}.
Interaction partners:
Sequence:
MEKNRTTTFSVYLTIILFLISTFITMVITESNIIRVPEFQCPNGYRKDANGKCREVFHG
Protein: Chloride channel accessory 3A2 (Chloride channel calcium activated 2) (Endothelial chloride channel) (Q9EQR4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVPGLQVLLFLTLHLLQNTESSMVHLNSNGYEGVVIAINPSVPEDERLIPSIKEMVTQASTYLFEASQGRVYFRNISILVPMTWKSKSEYLMPKRESYDKADVIVADPHLQHGDDPYTLQYGQCGDRGQYIHFTPNFLLTDNLRIYGPRGRVFVHEWAHLRWGVFDEYNVDRPFYISRKNTIEATRCSASITGKKVVHECQRGSCVTRACRRDSKTRLYEPKCTFIPDKIQTAGASIMFMQNLNSVVEFCTENNHNAEAPNLQNKMCNRRSTWDVIKASADFQNSPPMRGTEAPPPPTFSLLKSRRRVVCLVLDKSGSMDKEDRLIRMNQAAELYLTQIVEKESMVGLVTFDSAAHIQNYLIKITSSSDYQKITANLPQQATGGTSICHGLQAGFQAITSSDQSTSGSEIVLLTDGEDNGISSCFEAVSRSGAIIHTIALGPSAARELETLSDMTGGLRFYANKHVSSLIDAFSRISSTSGSVSQQALQLESKAFNVRAGAWINSTVPVDSTVGNDTFFVITWTVQKPEIILQDPKGKKYITSDFQDDELNIRSARLQIPGTAETGTWTYSITGTKSQLITMTVTTRARSPTMEPLLATAHMSQSTAQYPSRMIVYVRVSQGFLPVLGANVTAIIEAEHGHQVTLELWDNGAGADTVKNDGIYTRYFTDYHGNGRYSLKVRVQARKNKARLSLRQKNKSLYIPGYVENGKIVLNPPRPDVQEEAIEATVEDFNRVTSGGSFTVSGAPPDGDHARVFPPSKVTDLEAEFIGDYIQLTWTAPGKVLDKGRAHRYIIRVSQHPLGLQEDFNNATLVNASSLIPKEAGSKETFKFKPETFKIANDTQLYIAIQAYNEAGLTSEVSNIAQAVKFTSLEDSISALGADISAISMTVWGLAVIFNSILN
Protein: Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) (Q9Y5Y6)
Organism: Homo sapiens (Human)
Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Kunitz-type protease inhibitor 1
- Immunoglobulin heavy variable 3-43D
- Immunoglobulin kappa variable 1-33
- Serine protease inhibitor Kazal-type 5
- Coagulation factor VIII
- Kunitz-type protease inhibitor 2
- Filaggrin
- Kallikrein-5
- Furin
Sequence:
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
Protein: Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Q86SS6)
Organism: Homo sapiens (Human)
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Transient receptor potential cation channel subfamily V member 1
- Tubulin beta chain
- Vesicle-associated membrane protein 8
- Stonin-2
- Tubulin beta-2A chain
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 2
Sequence:
MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPRLRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLPSGSKDNNQEPLNYMDTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQTGIQENCAHGVRVQRQVTEPTSSARHNSIRRQLNLSNPDFNIQQLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLVEKR
Protein: Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2) (Q61247)
Organism: Mus musculus (Mouse)
Function: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Plasminogen
- Vitamin K-dependent protein C
- Fibrinogen alpha chain
- Fibronectin
- Fibrinogen gamma chain
- Prothrombin
- Fibrinogen beta chain
- Tissue-type plasminogen activator
- Pregnancy zone protein
- Vitronectin
Sequence:
MALLRGLLVLSLSCLQGPCFTFSPVSAVDLPGQQPVSEQAQQKLPLPALFKLDNQDFGDHATLKRSPGHCKSVPTAEETRRLAQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNTGSCLPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLTGKQEEDLANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFKNNMSFVVVMPTYFEWNVSEVLANLTWDTLYHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELFQGPDLRGISEQNLVVSSVQHQSTMELSEAGVEAAAATSVAMNRMSLSSFTVNRPFLFFIMEDTIGVPLFVGSVRNPNPSALPQLQEQRDSPDNRLIGQNDKADFHGGKTFGPDLKLAPRMEEDYPQFSSPK
Protein: Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (P21704)
Organism: Rattus norvegicus (Rat)
Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P24855}. Zymogen granule {ECO:0000250|UniProtKB:P24855}. Nucleus envelope {ECO:0000250|UniProtKB:P24855}. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. {ECO:0000250|UniProtKB:P24855}.
Interaction partners:
Sequence:
MRYTGLMGILLTLVNLLQLAATLRIAAFNIRTFGDTKMSNATLSSYIVKILSRYDIAVVQEVRDTHLVAVGKLLDELNRDIPDNYRYIISEPLGRKSYKEQYLFVYRPSQVSVLDSYHYDDGCEPCGNDTFSREPAIVKFFSPYTEVREFAIVPLHSAPTEAVSEIDALYDVYLDVRQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTATSTHCAYDRIVVAGALLQAAVVPSSAVPFDFQAEYRLTNQMAEAISDHYPVEVTLRKT
Protein: Avr9/Cf-9 induced kinase 1 (Q84QD9)
Organism: Nicotiana tabacum (Common tobacco)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MKITWESLVPSCFKGENPKPKAKEIKVVTKQSSFHRISISDFSASTISEDLSISLAGSNLYIFTLQELKVITQNFSSSNFLGEGGFGPVHKGFIDDKLRPGLKAQPVAVKLLDLDGTQGHREWLTEVIFLGQLRHPHLVKLIGYCCEEEHRLLAYEYMPRGSLENQLFRRYSVSLPWSTRMKIAVGAAKGLAFLHEAEKPVIYRDFKASNILLDSDYSAKLSDFGLAKDGPEGDDTHVSTRVMGTQGYAAPEYLMTGHLTAASDVYSFGVVLLELLTGRRSVDKTRPNREQNLVDWARPQLKDPRKLRRIMDPRLEGLYSEEGAQKAALVAYQCLSHRPKARPEMSSVVKTLEPLKDYKDISNMIFVYIAPAEVKEMCKESEKEDQKKTIKKENSPYHQKHHHHHLDRKHRRSPQNSTIYSEKALHKKLGPNSPLRNDFHRA
Protein: Molting defective, isoform D (A0A0B4K7S6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSANRRRRSASAASSIAAETATAATAATAEAISTAPSKEQLSPPIAGGSASADEDLLEMPRICRCCCKRDLKLLGLFEASQPTLANTTVASASAAASVASNKSSGTLAKTCATEAETETPQTLSANPVNPGTKATSSPSEAATTLSTSTRPASASFSSTSFSTSTSPMRRRTTNTTAPSASPAPRGRSSDNAVDYTLSGAHSSMDIVLEEMTIWMLNINRDDGLPQEICRQCMAQFLMVAKFRRKCVRMQQRLQDFAQEISDRQTARQAKRQQKVQKKTHDRWLQLEPTSHEEQQPIRKRRMVSESDGDSTAAAAAAEAATATATTPAKQVRTDFESLPPPKPSPQQHRVRKYRTLSIDCEMERPAASINASSMPWKTKAARKELSENWASSCSTAVMSPNRQRSSTSSSEHMSDLSVGPCCGFESDSNPSSTSNSARRTVILVKQQSPEKTSPMYDLMPRRGRRPRKAPIYMPAKRQRRSLVRKEPLYRKAQPVNEENKKSDQKDIYPKESRMEGLAPSCDEAIDSTSDAPMEVASNVVQKKCDEICLNGLIDSRNQLGAMEMEPVNEMIASNGVDKELTLSVQNNKETTSEEQIFEATSVIKESVQPEQSAEDIQVRTEIESIANDIRAEADLVQSEELTSSTETSESQPKAVEQLESMGKQESYALPQNMEAHESVQQTQTVDESDSADQREIIVSIPLEVLDENLQRRLCVDPETEAANRQSADPKEFALRPDDVNNNENDENFCQSATADSFNSAVALRTNKIEATPPGGTDSDDTDTDEVPIVPSGPTPMDFMAEFAKHCANGIEQLKVTTPVPSPTPSDLVPLNDLEAKQKLEVEMNDVETTLNGILNEMQDQHMYTPNCAHIDEFLTPADYATLTEQESSVSSPPNPFEQSSVAEPKDEKPSATEDPFDNSNFTNELIGFQNDIPCFENIETPEEGQNLHLELTQFLRDLQPSQSDPPAGEQVEKIEMETQPSTVQMDVQSNLPVQAADTQPQNESANHSPFESPISSPQVQSQIELQMEPQIETQMQPQIETRMQHDVLSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFHGELGYQCDGCDRTFEYLKELRKHRRTHSEMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSNNNSHASSDKLENPATPIEETPLTPMSSGGHLYHSPDEYPNSVESCAGNSVALESYATTP
Protein: Ethylene-responsive transcription factor ERF017 (Q84QC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Avr9/Cf-9 rapidly elicited protein
- ATPase family AAA domain-containing protein At1g05910
Sequence:
MEGSSSSMQSKYKGVRKRKWGKWVSEIRLPNSRERIWLGSYDTPEKAARAFDAALYCLRGNNAKFNFPDNPPVISGGRNLSRSEIREAAARFANSAEDDSSGGAGYEIRQESASTSMDVDSEFLSMLPTVGSGNFASEFGLFPGFDDFSDEYSGDRFREQLSPTQDYYQLGEETYADGSMFLWNF