wanglab/gogpt-training-data huggingface dataset:
Protein: Calcium-binding protein (Cex Ca2+-sensing low molecular weight GTPase) (RH52364p) (O16158)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSISDFRKKKLLFLFNVFFDVNQSGEIDVKDFELAIERVCQLRGWQKDTPKNKETYDLMMEIWTGLRSKADKDNDGQVSVDEWCNMWDAYAKDPSSVMDWQNAYMNFMFDLEDASHDGGIDVTEFTLVCSSYGLEKTECEEAFAKMSQGQSEVTREQFAALWKEYFAAEDVNAPGNYIFGKTSF
Protein: Sodium-dependent dopamine transporter (DA transporter) (DAT) (Q03614)
Organism: Caenorhabditis elegans
Function: Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9765501}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6}.
Interaction partners:
- Dopamine receptor 3
- Metallo-beta-lactamase domain-containing protein 1
- Dopamine receptor 2
- Aromatic-L-amino-acid decarboxylase
- Dopamine receptor 1
- Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
- Probable vesicular glutamate transporter eat-4
Sequence:
MQLVPTDDPDEKIGRTSNGMQNATLPIDGPVNTEPKDPAREQWSGKLDFLLSVVGFAVDLGNIWRFPYLCFKNGGGVFLIPYSIMVLLTGVPLFYMELCLGQYYRKGAITTWGRICPLFKGIGYCVILTAFYVDFFYNVILAWGLHYLYTSFSFNLPWASCNNSYNSPACYEPHWSEDGTAMCRSANQSVSAEKISAAEEYFYKGFLGLHEANAPNSHVIRSVTDLGNVRWDIALSLFVVYLICYFSMWKGIHTSGKVVWFTALFPYVVLGILFIRGVTLPGWQNGIEYYLRPNFEMLKRPSVWQDAATQVFFSLGPGFGVLMAYSSYNDFHNNVYVDALFTSFINCATSFLSGFVIFSVLGYMSCKSGKPIEAVAQEGPGLVFVVYPEALSTMPYAPFWSVLFFLMLMTLGLDSSFGGSEAIITGLSDEFPILKKNREVFVGCLFAFYMVIGIAMCTEGGILIMEWLIIYGTTWGLLIAVFCEAMVIAYIYGLRQFVHDVKEMMGFRPGNYWKFCWSCAAPFILLSMITSNFINYQALTYQDYTYPTAANVIGIIFALSGASFIPLVGIYKFVNARGNTISEKWQRVTMPYRKRPNQTEYIPIPTTQPHSDIML
Protein: Phosphate-specific transport system accessory protein PhoU (Pst system accessory protein PhoU) (Negative regulator of Pho regulon) (Q8FBT8)
Organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Function: Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex. Is also part of complex networks important for bacterial virulence, tolerance to antibiotics and stress response (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P0A9K7}.
Interaction partners:
- Phosphate import ATP-binding protein PstB
- Phosphate transport system permease protein PstA
- Phosphate transport system permease protein
- Phosphate regulon sensor protein PhoR
- Phosphate regulon transcriptional regulatory protein PhoB
- Phosphate-binding protein PstS
- Elongation factor Tu
- YaeQ protein
- Phosphate transporter
- Glutamate synthase large chain
Sequence:
MIQECVMDSLNLNKHISGQFNAELESIRTQVMTMGGMVEQQLSDAITAMHNQDSDLAKRVIEGDKNVNMMEVAIDEACVRIIAKRQPTASDLRLVMVISKTIAELERIGDVADKICRTALEKFSQQHQPLLVSLESLGRHTIQMLHDVLDAFARMDIDEAVRIYREDKKVDQEYEGIVRQLMTYMMEDSRTIPSVLTALFCARSIERIGDRCQNICEFIFYYVKGQDFRHVGGDELDKLLAEKDSDK
Protein: ENTH domain-containing protein C794.11c (P78813)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- dTTP/UTP pyrophosphatase
- Epsin-1
- Probable clathrin heavy chain
- Vesicle transport v-SNARE protein vti1
- Clathrin light chain
- Endocytosis protein end4
- AP-2 complex subunit alpha
- AP-1 complex subunit gamma-1
- AP-2 complex subunit beta
- AP-1 complex subunit beta-1
Sequence:
MESIQSTMKNINLYDIKAAVRKAQNVVMNYTSMEARVREATNNEPWGASTSLMMEIAQGTHNYSQLNEILPMIYRRFTEKTAEEWRQIYKALQLLEFLVKNGSERVVDDARAHQATIKMLRNFHYIDHRQKDQGLNVRTRAKELVELLNDSERIRKERKRARQNRGKFIGVGSDGDSRISTSSKSRFPSFGSSRGSYRTRVYGDGGGFTDYGNGYHDSSSMSDSRDASDNDVEEYNEDGDGGSSDAATANSTRGSRRTTTKQSDKAPEQPKQESAMIDLLGLDNEPSPAQPQTNTSAPLAFEDDGFGDFQSSAAAPASSTLNNASLFMGSQTASTAAKNDDDAFDDFQSAPSAKPASNTAAFSSISFGGFNSLNQLPTSSSAFTPQPTTFNTGYTSAFGMSSGLSNTSSQAGLGLTSQQPTAAKSSGSNGDAFGSLWSSAVNKVHQENSTRERVVSSSSEPVSKTQNFLDNDNLLL
Protein: Transcription regulator spe-44 (Spermatogenesis defective 44) (Q18171)
Organism: Caenorhabditis elegans
Function: Transcription factor which controls spermatogenesis and sperm cell fate by regulation of sperm gene expression.
Subcellular location: Chromosome {ECO:0000269|PubMed:22570621}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000269|PubMed:22570621}. Note=Localized along the length of most but not all of the autosomal pachytene chromosomes; not detected on X chromosome. {ECO:0000269|PubMed:22570621}.
Interaction partners:
Sequence:
MFGGDVSAASVLPSHPISGSCDGFQAEGSDHHHSTMTPFQESQRNVYQILYGHPANDDFPRPITPLQITIPEGDASPTVPVSCGVVNGKMHLNLFMCPGIHQPCIEVGNDLLSPKQFTIRGDKERQKDWKASIRVGRSSLRTHMEAMTIDFYEHMNRCSGKCQSRNYVNAPSEEVLQARKSKRTSEAGQLKYEIENEMAGKEADNDDNRKSAKKARGRPRGSVNKPRQMVKMEPQDDRFFEEFFIDAPPLQSMSSNEEPTSSNKESNECTPFNDILNCLQNDPMNFWSQMQQTGVIGHFCDDIIVSAINLKQSVMDNPVTPTTANMLTRTAFALGIPPVVVHRVQSIERNAYQQRKHDEMFNDIQSTLAEEHSVKYQPRTSSSSQESLHTAREFTEEKVEELIDVCKYDDYPESECLPGPSHIQ
Protein: Cordon-bleu protein-like 1 (Q53SF7)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein kinase C and casein kinase substrate in neurons protein 3
- Protein kinase C and casein kinase substrate in neurons protein 2
- Protein kinase C and casein kinase substrate in neurons protein 1
- Growth factor receptor-bound protein 14
Sequence:
MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVELSVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGMLEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKCEFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPAGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTISVNGRSRLSHSMSPDAQDGH
Protein: Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) (Q5QJ74)
Organism: Homo sapiens (Human)
Function: Acts as a regulator of tubulin stability.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Tubulin-specific chaperone D
Sequence:
MDQPSGRSFMQVLCEKYSPENFPYRRGPGMGVHVPATPQGSPMKDRLNLPSVLVLNSCGITCAGDEKEIAAFCAHVSELDLSDNKLEDWHEVSKIVSNVPQLEFLNLSSNPLNLSVLERTCAGSFSGVRKLVLNNSKASWETVHMILQELPDLEELFLCLNDYETVSCPSICCHSLKLLHITDNNLQDWTEIRKLGVMFPSLDTLVLANNHLNAIEEPDDSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKLVIARLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRYHELITKYGKLEPLAEVDLRPQSSAKVEVHFNDQVEEMSIRLDQTVAELKKQLKTLVQLPTSNMLLYYFDHEAPFGPEEMKYSSRALHSFGIRDGDKIYVESKTK
Protein: Protein NRT1/ PTR FAMILY 5.3 (AtNPF5.3) (Peptide transporter PTR3-B) (Q9FNL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Peptide transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- WAT1-related protein At3g28100
- WAT1-related protein At3g28130
- WAT1-related protein At3g28070
- WAT1-related protein At4g15540
- WAT1-related protein At3g28050
Sequence:
MTVEEVGDDYTKDGTVDLRGNRVRRSQTGRWKACSFVVVYEVFERMAYYGISSNLVIYMTTKLHQGTVKSSNNVTNWVGTSWLTPILGAYVADAHFGRYITFVISSAIYLLGMALLTLSVSLPGLKPPKCSTANVENCEKASVIQLAVFFGALYTLAIGTGGTKPNISTIGADQFDEFDPKDKIHKHSFFNWWMFSIFFGTFFATTVLVYVQDNVGWAIGYGLSTLGLAFSIFIFLLGTRLYRHKLPMGSPFTKMARVIVASLRKAREPMSSDSTRFYELPPMEYASKRAFPIHSTSSLRFLNRASLKTGSTHKWRLCTITEVEETKQMLKMLPVLFVTFVPSMMLAQIMTLFIKQGTTLDRRLTNNFSIPPASLLGFTTFSMLVSIVIYDRVFVKFMRKLTGNPRGITLLQRMGIGMILHILIMIIASITERYRLKVAAEHGLTHQTAVPIPLSIFTLLPQYVLMGLADAFIEIAKLEFFYDQAPESMKSLGTSYTSTSMAVGYFMSSILLSSVSQITKKQGRGWIQNNLNESRLDNYYMFFAVLNLLNFILFLVVIRFYEYRADVTQSANVEQKEPNMVDNYNE
Protein: Vomeronasal 2, receptor 120 (A0A3Q4EC41)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLIFVSVLLFLNFPVASCEPINPGCSLGMADAIFQDGDVLVDEFENFSYNLWEISSCSFDGDCIECVDYFCFLCLYTGYIQISINM
Protein: Probable small nuclear ribonucleoprotein Sm D1 (Sm-D1) (snRNP core protein D1) (Q9VU02)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P62314}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62314}.
Interaction partners:
- Probable small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Probable small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein-associated protein B
- Probable small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein C
- U1 small nuclear ribonucleoprotein A
- U1 small nuclear ribonucleoprotein 70 kDa
- Methylosome subunit pICln
Sequence:
MKLVRFLMKLSHETVTIELKNGTQIHGTITGVDVAMNTHLKSVRMTIKNRDPVHLETLSIRGNNIRYFILPDSLPLETLLIDDTPKSKTKKKDSGRVGNRGRGRGARGRGGPRGRGRGRASGRR
Protein: Panurgine K (PNG-K) (C0HL85)
Organism: Panurgus calcaratus (Solitary bee)
Function: Antimicrobial peptide active against Gram-positive bacteria M.luteus (MIC=1.6 uM) and B.subtilis (MIC=3.3 uM). Less active against Gram-negative bacteria E.coli (MIC=63.3 uM) and yeast C.albicans (MIC=24.2 uM). Not active against S.aureus and P.aeruginosa. Has no hemolytic activity against human erythrocytes. Probably acts by disrupting membranes of target cells.
Subcellular location: Target cell membrane {ECO:0000305|PubMed:23483218}. Secreted {ECO:0000269|PubMed:23483218}.
Interaction partners:
Sequence:
LDVKKIICVACKIKPNPACKKICPK
Protein: Malic enzyme (Q9NIW0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKPDSKLDKYAQRDRLGLWGTGDNEVVGSLSGFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNERLFYNVLSSDIGYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGVITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVNKLAFIKAQMYDLDYPRSVPATYKM
Protein: GTPase-activating protein (Ras GTPase-activating protein) (P33277)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras1.
Interaction partners:
- Ras-like protein 1
- Protein ste6
Sequence:
MTKRHSGTLSSSVLPQTNRLSLLRNRESTSVLYTIDLDMESDVEDAFFHLDRELHDLKQQISSQSKQNFVLERDVRYLDSKIALLIQNRMAQEEQHEFAKRLNDNYNAVKGSFPDDRKLQLYGALFFLLQSEPAYIASLVRRVKLFNMDALLQIVMFNIYGNQYESREEHLLLSLFQMVLTTEFEATSDVLSLLRANTPVSRMLTTYTRRGPGQAYLRSILYQCINDVAIHPDLQLDIHPLSVYRYLVNTGQLSPSEDDNLLTNEEVSEFPAVKNAIQERSAQLLLLTKRFLDAVLNSIDEIPYGIRWVCKLIRNLTNRLFPSISDSTICSLIGGFFFLRFVNPAIISPQTSMLLDSCPSDNVRKTLATIAKIIQSVANGTSSTKTHLDVSFQPMLKEYEEKVHNLLRKLGNVGDFFEALELDQYIALSKKSLALEMTVNEIYLTHEIILENLDNLYDPDSHVHLILQELGEPCKSVPQEDNCLVTLPLYNRWDSSIPDLKQNLKVTREDILYVDAKTLFIQLLRLLPSGHPATRVPLDLPLIADSVSSLKSMSLMKKGIRAIELLDELSTLRLVDKENRYEPLTSEVEKEFIDLDALYERIRAERDALQDVHRAICDHNEYLQTQLQIYGSYLNNARSQIKPSHSDSKGFSRGVGVVGIKPKNIKSSNTVKLSSQQLKKESVLLNCTIPEFNVSNTYFTFSSPSTDNFVIAVYQRGHSKVLVEVCICLDDVLQRRYASNPVVDLGFLTFEANKLYHLFEQLFLRK
Protein: E4 SUMO-protein ligase PIAL1 (EC 2.3.2.-) (Protein EMBRYO DEFECTIVE 3001) (Protein INHIBITOR OF ACTIVATED STAT-LIKE 1) (A0A0A7EPL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E4-type SUMO ligase that promotes SUMO chain formation in a SCE1-dependent manner and thus contributes to a pathway for proteolytic removal of sumoylation substrates. Involved in stress responses (e.g. osmotic, salt and abscisic acid ABA) and sulfur metabolism.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SUMO-conjugating enzyme SCE1
- E3 SUMO-protein ligase MMS21
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 5
- E4 SUMO-protein ligase PIAL2
- Small ubiquitin-related modifier 3
- SUMO-activating enzyme subunit 2
- Putative small ubiquitin-related modifier 4
- SUMO-activating enzyme subunit 1A
Sequence:
MVIPATSRFGFRAEFNTKEFQASCISLANEIDAAIGRNEVPGNIQELALILNNVCRRKCDDYQTRAVVMALMISVKSACQLGWFPERETQELLAIIDLMWNGFSCPENVTSCVNSPVTLISQVIERFYPCVKLGHILVSFEAKPESKMMMKDFHISKKMPHSPKQKVGLFVVRTEDISRSNCIVHPQGVSFLLNGKGIDKRVNISMESGPQLPTNVTALLNLGANLLQAIGCFGGSYLIAIAFMDVIPLPNKPLLKDYVHPEVVGSNSDCDIIEGPSRISLSCPISRTRIKLPVKGHVCKHLQCFDFWNYVNMNTRRPSWRCPHCNQSVCYTDIRVDQKLRKILEEVGRNAADVVISADGTWMVETENDEDVELVPETTHDHGDPNSFINLGPTVKNPARDENEMETSTQVEEHNPCLSEIQGPSNDTHRPASDYTMLNQSHTSTNTLPQLPRTLNAFDGQQFVNLPQVINTRDSPASQALPMTFSPTPSPQDILATNAANFGTSMPAAQSSQFQGSHVTSLGNCEGRTSDLMARWNHIYGRVQTQFPPAPLSHHHYSMQNQSPSPAQQRPVPSYIAHPQTFHVNYGENADQRWMPSSIAHPQTLPVNYGGNTNQRPIPSSIAHPQTLPVNYRGNTDHRSTPYSITHLQTLLNYGGNADQRPMPSSITNLQTLPATYGGYAHQRPMSSSITHPRTSPVNYGGTPDQRPMPSSITHPQTLPVSYGGTTDQILNPGGAMGQFSSREFMNLTPANTENWRPQSRMRGSVAPGTGYDHMIIHPTRPVHPQAQTPPAPLSTSYDGADEIQAFIGHPSYPVSNNETQAGTSSLPVAEGLGYSGSFWSMPPETW
Protein: Protein C (P06164)
Organism: Bovine parainfluenza 3 virus (BPIV-3)
Interaction partners:
Sequence:
MLKTIKSWILGKRDQETSHLTSHRPSTSLNSYSAPTPKRTRQTAMKSTQGTRDSARQSTNLNPKQQKQAKKIVDQLTKIDSLGHHTNVPQRQRIEMLIRRLYREEIGEEAAQIVELRLWSLEESPEAAQILTMEPKSRKVLITMKLERWIRTLLRGKCDNLKMFQSRYQEVMPFLQQNKMETVMMEEAWNLSVHLIQDIPA
Protein: Uracil phosphoribosyltransferase homolog (A0A8I6G3Q5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATELQRPDSMPCHNRQVNSTSSPSPERLLAEDPVLDHAEENNAAMAKLTLLPGHAHSSVLSERDSPACCSTNLHCENHSDSSDSGNYEAPVGDSLLGDCELYPQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGHKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIHRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD
Protein: Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b) (P11215)
Organism: Homo sapiens (Human)
Function: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Integrin beta-2
- Intercellular adhesion molecule 1
- Complement C3
- Thy-1 membrane glycoprotein
- Intercellular adhesion molecule 2
- Junctional adhesion molecule C
- Integrin alpha-L
- Vascular cell adhesion protein 1
- Platelet glycoprotein Ib alpha chain
- Transcription factor PU.1
Sequence:
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ
Protein: Large ribosomal subunit protein uL6 (60S ribosomal protein L9) (P32969)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL37
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL28
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL21
Sequence:
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE
Protein: Thiol-disulfide oxidoreductase ResA (P35160)
Organism: Bacillus subtilis (strain 168)
Function: Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. Does not play a role in sporulation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12637552}; Single-pass type II membrane protein {ECO:0000269|PubMed:12637552}. Note=The thioredoxin-like motif is exposed on the outside of the membrane.
Interaction partners:
- Cytochrome c biogenesis protein ResB
- Cytochrome c-type biogenesis protein CcdA
- Cytochrome c biogenesis protein ResC
- Sensor histidine kinase ResE
- Transcriptional regulatory protein ResD
- Disulfide bond formation protein D
- Cytochrome c-550
Sequence:
MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPNFVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVNVGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTMTESMIHDYMNLIKPGETSG
Protein: WD repeat protein (Q8L403)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein 18 homolog
- Putative WD-repeat membrane protein
- M phase phosphoprotein 10
- Nucleolar-like protein
- Protein SLOW WALKER 1
- Transducin family protein / WD-40 repeat family protein
- At4g28200
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Protein NUCLEOLAR COMPLEX ASSOCIATED 4
Sequence:
MAKDKLKPLLSSDAAGDIADTPLREKKHKKKSKKRAEPEPDIPSTRDSGLDEDRDGVLVDDTLNEPTIGDKLESLDLLNGEKVNSEESNRDSAPGDDKPPTAASVNVLLRQALHADDRSLLLDCLYNRDEQVIANSVAKLNSAEVLKLLNALLPILQSRGAILACTIPWIKSLLLTHSSGIMSQESSLLALNTMYQLIESRVSTIHTAVEVSSGLDLIVDDLDEEEDEGPVIYEDKDSDEDEEEGIEEAMETDEEADDSADEAADGVNDFEGFDDMSD
Protein: Beta-xylanase (EC 3.2.1.8) (O32374)
Organism: Acetivibrio thermocellus (Hungateiclostridium thermocellum) (Clostridium thermocellum)
Interaction partners:
Sequence:
MLKKKLLTLLTVFALLTVGICGSFLPLPKASAAALIYDDFETGLNGWGPRGPETVELTTEEAYSGRYSLKVSGRTSTWNGPMVDKTDVLTLGESYKLGVYVKFVGDSYSNEQRFSLQLQYNDGAGDVYQNIKTATVYKGTWTLLEGQLTVPSHAKDVKIYVETEFKNSPSPQDLMDFYIDDFTATPANLPEIEKDIPSLKDVFAGYFKVGGAATVAELAPKPAKELFLKHYNSLTFGNELKPESVLDYDATIAYMEANGGDQVNPQITLRAARPLLEFAKEHNIPVRGHTLVWHSQTPDWFFRENYSQDENAPWASKEVMLQRLENYIKNLMEALATEYPTVKFYAWDVVNEAVDPNTSDGMRTPGSNNKNPGSSLWMQTVGRDFIVKAFEYARKYAPADCKLFYNDYNEYEDRKCDFIIEILTELKAKGLVDGMGMQSHWVMDYPSISMFEKSIRRYAALGLEIQLTELDIRNPDNSQWALERQANRYKELVTKLVDLKKEGINITALVFWGITDATSWLGGYPLLFDAEYKAKPAFYAIVNSVPPLPTEPPVQVIPGDVNGDGRVNSSDLTLMKRYLLKSISDFPTPEGKIAADLNEDGKVNSTDLLALKKLVLREL
Protein: Ankyrin 2 (A0A5F9ZI16)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MNGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEGGSFLVLVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE