wanglab/gogpt-training-data huggingface dataset:
Protein: Protein LSD1 (Protein CHILLING SENSITIVE 4) (Protein LESION SIMULATING DISEASE 1) (AtLSD1) (Putative zinc finger LSD1) (P94077)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16957775}. Nucleus {ECO:0000269|PubMed:16957775}.
Interaction partners:
- Putative vacuolar protein sorting-associated protein 24 homolog 2
- Vacuolar protein sorting-associated protein 24 homolog 1
- Vacuolar protein sorting-associated protein 32 homolog 2
- Vacuolar protein sorting-associated protein 32 homolog 1
- Toll-Interleukin-Resistance
- Protein DA1-related 4
- Transmembrane protein
- Vacuolar protein sorting-associated protein
- Protein SUPPRESSOR OF K
- GSH-induced LITAF domain protein
Sequence:
MKVADMQDQLVCHGCRNLLMYPRGASNVRCALCNTINMVPPPPPPHDMAHIICGGCRTMLMYTRGASSVRCSCCQTTNLVPAHSNQVAHAPSSQVAQINCGHCRTTLMYPYGASSVKCAVCQFVTNVNMSNGRVPLPTNRPNGTACPPSTSTSTPPSQTQTVVVENPMSVDESGKLVSNVVVGVTTDKK
Protein: Geranylgeranyl pyrophosphate synthase 6, mitochondrial (GGPP synthase 6) (GGPS6) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase 6) (Dimethylallyltranstransferase 6) (EC 2.5.1.1) (Farnesyl diphosphate synthase 6) (Farnesyltranstransferase 6) (EC 2.5.1.29) (Geranyltranstransferase 6) (EC 2.5.1.10) (O22043)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10759500, ECO:0000269|PubMed:9349257}.
Interaction partners:
- Geranylgeranyl diphosphate reductase, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Phytoene synthase 1, chloroplastic
- Isopentenyl phosphate kinase
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Ent-copalyl diphosphate synthase, chloroplastic
- Heterodimeric geranylgeranyl pyrophosphate synthase small subunit
- Isopentenyl-diphosphate Delta-isomerase I, chloroplastic
- Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
Sequence:
MRPRYSLILSAMRLIRPSNRRLSSIASSDSEFISYMKNKAKSINKALDNSIPLCNNFVPLWEPVLEVHKAMRYTLLPGGKRVRPMLCLVACELVGGQESTAMPAACAVEMIHAASLILDDLPCMDDDSLRRGKPTNHKVFGEKTSILASNALRSLAVKQTLASTSLGVTSERVLRAVQEMARAVGTEGLVAGQAADLAGERMSFKNEDDELRYLELMHVHKTAVLVEAAAVVGAIMGGGSDEEIERLKSYARCVGLMFQVMDDVLDETKSSEELGKTAGKDLITGKLTYPKVMGVDNAREYAKRLNREAQEHLQGFDSDKVVPLLSLADYIVKRQN
Protein: Histone acetyltransferase SAS3 (EC 2.3.1.48) (Something about silencing protein 3) (P34218)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. In vitro, SAS3 acetylates free histones H3 and H4. It is involved in silencing the HMR locus.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein YNG1
- NuA3 HAT complex component NTO1
- Chromatin modification-related protein EAF6
- Transcription initiation factor TFIID subunit 14
- NuA3 HAT complex component PDP3
- Histone acetyltransferase GCN5
- Histone H3
- Histone H4
- FACT complex subunit SPT16
- Elongator complex protein 3
Sequence:
MSLTANDESPKPKKNALLKNLEIDDLIHSQFVRSDTNGHRTTRRLFNSDASISHRIRGSVRSDKGLNKIKKGLISQQSKLASENSSQNIVNRDNKMGAVSFPIIEPNIEVSEELKVRIKYDSIKFFNFERLISKSSVIAPLVNKNITSSGPLIGFQRRVNRLKQTWDLATENMEYPYSSDNTPFRDNDSWQWYVPYGGTIKKMKDFSTKRTLPTWEDKIKFLTFLENSKSATYINGNVSLCNHNETDQENEDRKKRKGKVPRIKNKVWFSQIEYIVLRNYEIKPWYTSPFPEHINQNKMVFICEFCLKYMTSRYTFYRHQLKCLTFKPPGNEIYRDGKLSVWEIDGRENVLYCQNLCLLAKCFINSKTLYYDVEPFIFYILTEREDTENHPYQNAAKFHFVGYFSKEKFNSNDYNLSCILTLPIYQRKGYGQFLMEFSYLLSRKESKFGTPEKPLSDLGLLTYRTFWKIKCAEVLLKLRDSARRRSNNKNEDTFQQVSLNDIAKLTGMIPTDVVFGLEQLQVLYRHKTRSLSSLDDFNYIIKIDSWNRIENIYKTWSSKNYPRVKYDKLLWEPIILGPSFGINGMMNLEPTALADEALTNETMAPVISNNTHIENYNNSRAHNKRRRRRRRSSEHKTSKLHVNNIIEPEVPATDFFEDTVSSLTEYMCDYKNTNNDRLIYQAEKRVLESIHDRKGIPRSKFSTETHWELCFTIKNSETPLGNHAARRNDTGISSLEQDEVENDVDTELYVGENAKEDEDEDEDFTLDDDIEDEQISEENDEEEDTYEEDSDDDEDGKRKGQEQDENDIESHIRKERVRKRRKITLIEDDEE
Protein: ER membrane protein complex subunit 1 (Q8N766)
Organism: Homo sapiens (Human)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Single-pass type I membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
Interaction partners:
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 5
- Endoplasmic reticulum membrane protein complex subunit 7
- ER membrane protein complex subunit 9
- Dynactin subunit 4
Sequence:
MAAEWASRFWLWATLLIPAAAVYEDQVGKFDWRQQYVGKVKFASLEFSPGSKKLVVATEKNVIAALNSRTGEILWRHVDKGTAEGAVDAMLLHGQDVITVSNGGRIMRSWETNIGGLNWEITLDSGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIHYQMVYSYGSGVVWALGVVPFSHVNIVKFNVEDGEIVQQVRVSTPWLQHLSGACGVVDEAVLVCPDPSSRSLQTLALETEWELRQIPLQSLDLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSPSHYALLQYHYGTLSLLKNFPQTALVSFATTGEKTVAAVMACRNEVQKSSSSEDGSMGSFSEKSSSKDSLACFNQTYTINLYLVETGRRLLDTTITFSLEQSGTRPERLYIQVFLKKDDSVGYRALVQTEDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEINIDTLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNVKPDSSFKLMVQRTTAHFPHPPQCTLLVKDKESGMSSLYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLRQLHELAPSIFFYLVDAEQGRLCGYRLRKDLTTELSWELTIPPEVQRIVKVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQVKLLNRAWR
Protein: Anoctamin-3 (Transmembrane protein 16C) (Q9BYT9)
Organism: Homo sapiens (Human)
Function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Shows an intracellular localization. {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Cip1-interacting zinc finger protein
- THAP domain-containing protein 1
- Torsin-1A
Sequence:
MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP
Protein: Beaten path IIIc, isoform A (RE14414p) (Q8SY13)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFGHLSLLAALFFIGTLKDFRVAGLRLTEVRIPMYVIKGTAAQLECLYDLDGEALYSVKWYKDGNEFYRYVPRDMPPAQTFLLPGVNVDLHNSSDAIVTLRNVNLQSAGRFRCEVSGEAPSFQTVTEHGDMIVAYLPDEGSPKISGGRPRYQIGDYVRVNCTAGRSKPAVKLSWQVNGEPVEQQKLRKYDTIVSGRDGLETSVLGLQFRVEQKHFRKGNMKLKCIAELSTVYWRCNEESVEGDRPQKAPVLESRETVYASNSRADPVQGTSYRELFVTKILSLLFVQPNAASSTASAPSTPITPLVLLPVALAVMVMATLAQGITRDIDTDKISMDRTAPGGIGITKETQQARELLAGRKEENRRTSHGKSATQLEKIALTAR
Protein: Protein pinocchio (Q9VPW8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in olfaction.
Interaction partners:
- FI02826p
Sequence:
MKTGSNNNHISASSSSSNNNNNSSLVQQQQQRSTTSVSVSSSHIVTEWEDGIIFDVDDPDFCNLATDKLNFIVPSAANMSIASVHGPQIADICSPLSHHNLGLSASLPDLVGSPLEISMDNVLTIEELRQHMGSCFTCGVSWTDDHVSLDCSECGGYSLERPCPLCDGQCGVQWKRDFAMSHACSQARWVGVCISYPEVVAGVQLPVGAGAGAATSCAAAAANQLRLAQELCSRLEQLSTSTASKSGRI
Protein: Probable WRKY transcription factor 74 (WRKY DNA-binding protein 74) (Q93WU6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cytochrome P450 71B8
- Putative cytochrome P450 71A28
Sequence:
MEEVEAANKAAVESCHGVLNLLSQQTNDSKSIMVETREAVCKFKRVSSLLSRGLGQRKIKKLNNNNYKFSSSLLPQHMFLESPVCSNNAISGCIPILAPKPLQIVPAGPPPLMLFNQNMCLDKSFLELKPPSSRAVDPKPYQFIHTHQQGVYSRSKSGLNLKFDGSIGASCYSPSISNGSRSFVSSLSMDGSVTDYDRNSFHLIGLPQGSDHISQHSRRTSCSGSLKCGSKSKCHCSKKRKLRVKRSIKVPAISNKIADIPPDEYSWRKYGQKPIKGSPHPRGYYKCSSVRGCPARKHVERCVEETSMLIVTYEGEHNHSRILSSQSAHT
Protein: E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) (Q6Q0C0)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Cytoplasm {ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:37086853}. Nucleus {ECO:0000269|PubMed:37086853}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Interaction partners:
- Ubiquitin-ribosomal protein eL40 fusion protein
- Mitogen-activated protein kinase kinase kinase 3
- Myc-associated zinc finger protein
- Ubiquitin-conjugating enzyme E2 E2
- Merlin
Sequence:
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
Protein: Y' element ATP-dependent helicase protein 1 copy 5 (EC 3.6.4.12) (P0CX21)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
Sequence:
MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVISVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDTNGVAMWKWIKILYHEVAQETTLKDSYRITLVPSSDGISVCGKLFNREYVRGFYFACKAQFDNLWGELNNCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMVHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHDQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIIALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSAITTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
Protein: Syntaxin-7 (O70439)
Organism: Mus musculus (Mouse)
Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).
Subcellular location: Early endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Syntaxin-8
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Vesicle-associated membrane protein 7
- Vesicle-associated membrane protein 8
- Synaptobrevin homolog YKT6
- Synaptosomal-associated protein 29
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-6
- Vesicle-associated membrane protein 4
- Synaptosomal-associated protein 23
Sequence:
MSYTPGIGGDSAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQLLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKAQRQAAEREKEFVARVRASSRVSGGFPEDSSKEKNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDMIDSIEANVESAEVHVQQANQQLSRAADYQRKSRKTLCIIIFILVVRIVIICLIVWGLKG
Protein: Drebrin like (H7C111)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
XKQKERAMSTTSISSPQPDLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
Protein: Uncharacterized protein, isoform E (M9PC26)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP03784p
Sequence:
MDIALRGTNRASSTSTTGTGLHHAVSLGNIEVSTKTTYSSHMDRSYDSEDEHTGRRRLRHTLSTELHPHTSVYSRGDIREQYCLTDRQLHSIEQRPRRERFFGCLSRRGQTQSGSFLGGCVGRRVPSDENLAAYAPFEKYPRYQNSYTDTHELESSYFRRQPASILSTGKSGEADLGGRYTWIGQQQVTNNNPDYQSDHSSYHCPTYATMPTTHHQHHHQQQGGNVRTKHVSFARSHTLTSFDNVNAGFRSSGRLKTARSQERLIGGKKPIIATGSMYETLQPPLQVQQQPQQMQPQQSSTLPKTWLPPPVQLQPCQHHHAPIHLHQPISDNMVGLIIPQPLPLALPLPSPEVLIVEKKFRNAMKTQATQTDAAARRQGQLGYNTQVLALSPRPPHRIKVVSQGAQTNGLQNGKKLTKSLSEIPNGKDGTSSHHYQQGSIYPHEMIYRTQSQDVTPLQTLSDAQNNIMYYKPPPPLLDAHSYGLGMEHLSRTRPSPSEQNVEYVNVNAAAVALNESFDYESNSLPRRACTSHTDFYSNSLPRRHITESSELMTDSVPLDFSQSHLLPPPSEYCKNDDEDVEEYYDEDEDHPHETESYSSEVCMEQAAQHRRMSMLPQMIDSPFRRDDLRRQSMPVYGQTEKLIDGFGPRSSFRRRDKVSCFPDEPPAVQEVRDEQEIFIDFKPHISPKPSPKLQLKHRKQHKAEIAMRKMQQQRMAQAAALTLPKPKSQPVEVEVRKVELEPSDEEEDEDEVSEPEEEDDGEEIDDDEQKLETDLQEDEEPLYENITPCGCRVVPTSDAEDIQDKRSQFRKRSVSLDDDYEAKASETPTPTGLRLPSTPASPCRDELLANVSTYPSSDSLANDNTRDHSDGIWNESQVTVLTAEQRDISDGSYSSNLLLTPSSKRKNLLLQHQQRSSVDTDALDFEEQSPTYGLQTLPKIIKTPTPTTSRPTSTQPMMPPPAIAVTPSTNQILDSCISSPLPKRSMVARGSVPDARQLMFTSGATKQRHSDASFLPMGAADYARSADISECSTNTDEYATCTDTSKRTPVSTQSSQLEKTHAGSSFESASSLYSMREDLLQHDEKERDKQTTLTKAQLKSPIGSVAELTRKSPSHSISSTTSSGSCPVLGAAIKSPAKESLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGYYESPHEEDDEEQGTRSKARRLRQEDERKRRKTSMKLDIEKENMRALTSPIKKPTGSSKITSPEQSISGTMDNGSSPSKMKRFRPKIRRQLRKSSREDVLAAAAVRRSRATPTIFGLSSGSGDTELLLDASMSTGAVAGTTTSAVTSVSAPSSASKLPTSESSVTTQPEAVVAPLPAKKPHSCATPTSLLSPKLPTTSGTQSKSTSDTFQLKAKSIESLRSVSPGSDSVFYSEADGNAASGEQSHCHHCGKEMEGKQQSNTISELAGDSVESIPYIEQDIVKPPSDFADSPVTTKTTQRLYKKMDKRFRSEERYHGERGRHYKTRQENIRAKSEERGRIPSLPNTPVLRPAGSSPCVLPDTEQSQHIIYKGHYDAGRYTRLTDDDLWTQLDHQCFDRSRERRASTESEKGFHAKYQVILHRLVQRRCTLEMYHRQKHNSFLWAKCKEISAKSFRNIFAVFTQYSGQMIELIASNSTPDSIRRKLEEVLKLMLLVWARESYVISKLSNGAHGVDKTVVVKSDSGEFGFRIHGSKPVVVAAIEPETPAESSGLEVGDIIISVNGVQVLDKHHTEVVKIAHDGCEKLELQVARTIGVLMHEQLEPPSQPIFSGYLWRQSGQAKGAPNSKKWVRRWFSLRPDNCLYYYKTEDDSQPVGAMIMAKHTVDLCPVDVGKPFAFKVDAGEGIPMYVAADSDEMANRWLQLLRQAASQDNQWLDKSARCLYQSPSNIQRPDCFGYLLKLGSRWCGWSKRYCVLKDACLYFYQDANSKSAFGMACLHGYKVASMSANASGKKNSFEIVPPETKLRHYFFCTESEMDKKRWISALEYSIDRWIKSG
Protein: Eukaryotic translation initiation factor isoform 4E-2 (eIF(iso)-4E-2) (eIF(iso)4E-2) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (mRNA cap-binding protein) (Q03389)
Organism: Triticum aestivum (Wheat)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0A445AGS0}. Nucleus {ECO:0000250|UniProtKB:A0A445AGS0}.
Interaction partners:
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor isoform 4G-1
- MI domain-containing protein
- MI domain-containing protein
- Eukaryotic translation initiation factor isoform 4G-2
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor 4G
Sequence:
MAEVEAALPVAATETPEVAAEGDAGAAEAKGPHKLQRQWTFWYDIQTKPKPGAAWGTSLKKGYTFDTVEEFWCLYDQIFRPSKLVGSADFHLFKAGVEPKWEDPECANGGKWTVISSRKTNLDTMWLETCMALIGEQFDESQEICGVVASVRQRQDKLSLWTKTASNEAVQVDIGKKWKEVIDYNDKMVYSFHDDSRSQKPSRGGRYTV
Protein: Codanin-1 (Q8IWY9)
Organism: Homo sapiens (Human)
Function: May act as a negative regulator of ASF1 in chromatin assembly.
Subcellular location: Cytoplasm. Nucleus. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Mainly detected as a cytoplasmic protein.
Interaction partners:
- Protein transport protein Sec23B
- CDAN1-interacting nuclease 1
- Histone chaperone ASF1A
- Histone chaperone ASF1B
- Stereocilin
- Cation channel sperm-associated protein 2
- Alanine--tRNA ligase, mitochondrial
- PR domain zinc finger protein 15
- Importin-4
- Krueppel-like factor 1
Sequence:
MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRALRKEFVPFLLNFLREQSSRVLPQGPPTPAKTPGASAALPGRPGGPPRGSRGARSQLFPPTEAQSTAAEAPLARRGGRRRGPGPARERGGRGLEEGVSGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPPVGSVPPGPTGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSPLPSRTGSLTDEPADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDPELSPAVLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKVSLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGESDVDWQGERKQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPPTGELQDSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAPEHGLDNAPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPSQTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGDPAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSLWKEDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFLAEPHLPEPQLRACELVQPNRGTVLAQS
Protein: Dihydrofolate reductase (EC 1.5.1.3) (G4VJD6)
Organism: Schistosoma mansoni (Blood fluke)
Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Interaction partners:
Sequence:
MRLNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTKAHPGLKNAVVMGRVTWESIPESFKPLKDRINIVVSSTLSHAPSFVQVVPSLNAAIDLLYNEEFSSIVDEVFIIGGYRLYKEALKQSIYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTFKFCVYDVPSEQFI