wanglab/gogpt-training-data huggingface dataset:
Protein: SPI-1 type 3 secretion system ATPase (T3SS-1 ATPase) (EC 7.4.2.8) (Invasion protein InvC) (P0A1B9)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Acts as a molecular motor to provide the energy that is required for the export of proteins (Probable). Required for type III secretion apparatus (T3SA) formation, proper protein secretion, host cell invasion and virulence. May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion. Releases the effector protein SptP from the chaperone SicP in an ATP-dependent manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28283062, ECO:0000305|PubMed:15060043}. Note=Associated with the membrane, presumably through interactions with other components of the SPI-1-encoded T3SS. {ECO:0000269|PubMed:15060043, ECO:0000269|PubMed:28283062}.
Interaction partners:
- Surface presentation of antigens protein SpaP
- SPI-1 type 3 secretion system secretin
- Invasion protein InvA
- Surface presentation of antigens protein SpaM
- Surface presentation of antigens protein SpaN
- Surface presentation of antigens protein SpaS
- Protein PrgH
- Surface presentation of antigens protein SpaK
- Invasion protein InvE
- Surface presentation of antigens protein SpaO
Sequence:
MKTPRLLQYLAYPQKITGPIIEAELRDVAIGELCEIRRGWHQKQVVARAQVVGLQRERTVLSLIGNAQGLSRDVVLYPTGRALSAWVGYSVLGAVLDPTGKIVERFTPEVAPISEERVIDVAPPSYASRVGVREPLITGVRAIDGLLTCGVGQRMGIFASAGCGKTMLMHMLIEQTEADVFVIGLIGERGREVTEFVDMLRASHKKEKCVLVFATSDFPSVDRCNAAQLATTVAEYFRDQGKRVVLFIDSMTRYARALRDVALASGERPARRGYPASVFDNLPRLLERPGATSEGSITAFYTVLLESEEEADPMADEIRSILDGHLYLSRKLAGQGHYPAIDVLKSVSRVFGQVTTPTHAEQASAVRKLMTRLEELQLFIDLGEYRPGENIDNDRAMQMRDSLKAWLCQPVAQYSSFDDTLSGMNAFADQN
Protein: Omega-agatoxin-Aa4a (Omega-AGTX-Aa4a) (Omega-agatoxin IVA) (Omega-Aga-IVA) (Omega-agatoxin-4A) (P30288)
Organism: Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Function: Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons.
Subcellular location: Secreted {ECO:0000269|PubMed:1311418}.
Interaction partners:
Sequence:
KKKCIAKDYGRCKWGGTPCCRGRGCICSIMGTNCECKPRLIMEGLGLA
Protein: Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (MRP-S5) (S5mt) (Q99N87)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P82675}.
Interaction partners:
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS10m
Sequence:
MAAAVRAAGCLPALCSLQAGHFLSRQLSLNAFPVAATSFLAVKTALSHGSLSSRETRRNHCLTSLSHVLQTQCCVSSPGNWTGQQCRPYSFFTKLTAEELWKGALAETGAGARKGRGKRTKKKKRKDLNRGQIIGEGRSGFLWPGLNVPLIKSGVVQNIGQRSKEEQQKVEATMVEQREEWDRKRKIKVKRERGWSGNTWGGVSIGPPDPGPNGETYEDFDTRILEVRNVFNMTAKEGRKKSVRVLVAVGNGNGAAGFAIGKAADRGDAFRKAKNRAIHYLHYIERYEGHTIFHDISLRFKRTQIRMKKQPRGYGLRCHRAIITICRLIGIKDMYARVTGSMNMLNLTRGLFHGLARQETHQHLADKKGLHVVEFREECGPLPIVVASPHGALSKEPEPEPEVPDTKLDWQDVKAMQGLKRSVWFNLKRPAT
Protein: Syndetin (Bcl2-like protein blm) (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) (Q8CI71)
Organism: Mus musculus (Mouse)
Function: Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular location: Recycling endosome {ECO:0000250|UniProtKB:Q96JG6}. Membrane {ECO:0000250|UniProtKB:F1LSG8}. Note=Associates with membranes in an EIPR1-dependent manner. {ECO:0000250|UniProtKB:F1LSG8}.
Interaction partners:
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 51 homolog
- Vacuolar protein sorting-associated protein 52 homolog
- EARP and GARP complex-interacting protein 1
- Vacuolar protein sorting-associated protein 54
- Coiled-coil domain-containing protein 186
- HEPACAM family member 2
Sequence:
MQKIKSLMTRQGLKSPPESLNDLGAFESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSADPFDIVKYELEKLPPVLNLQELEEYRDKLKQQQSAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDIRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEETAAAAEGSNVMSTEEATFDRGYVKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIVSRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNHHRIRLDELRMFLENETWELCPVKSNFSILQLHEFKFLEQSRSPSVSPSKQPSATSSKPVTLFEQYCSGGNPFEIQADHKDEETEDVLASNGYESDEQEKSAYQDYDSDSDVPEELKRDYVDEQTGDVPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLKTTLNRIQESLIDLEGSADPTATLTAAEERKEKVPSPHLNQLVILTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKAIDYEQMLLLMMNVKWDVKEIMSQHNIYVDALLKEFEQFNKRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKARQKLLAAIDEIDRPKR
Protein: DNA-directed RNA polymerase subunit alpha (PEP) (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (RNA polymerase subunit alpha) (P0C500)
Organism: Oryza sativa subsp. japonica (Rice)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS8c
- Os01g0220300 protein
- Small ribosomal subunit protein uS2c
- DNA-directed RNA polymerase subunit beta'
- Os02g0102400 protein
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein bS16c
- Os08g0513300 protein
- Os07g0658200 protein
Sequence:
MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRTASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPTDFRIELRIKRDRGYHTEVRKNTQDGSYPIDAVSMPVRNVNYSIFACGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENKNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKHLPMDLPKNKF
Protein: Elongator complex protein 6 (Gamma-toxin target 6) (HAT-associated protein 3) (Q04868)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitivity to Pichia inositovora toxin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15780940}. Nucleus {ECO:0000269|PubMed:10024884}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 5
- Elongator complex protein 3
- Elongator complex protein 4
- Elongator complex protein 2
- Cytoplasmic tRNA 2-thiolation protein 2
- Cytoplasmic tRNA 2-thiolation protein 1
- Adenylyltransferase and sulfurtransferase UBA4
- Ubiquitin-related modifier 1
- Protein KTI12
Sequence:
MGSVQRQDLVLFSDQSVLPAHFFQDSNSHNLFFITHQSCTQPLWMINALVETHVLGSPSSLNESSSSMLPSSTRSHAVLASFIHEQNYFTNSLNKLKIPSNNYNVLDFLSDFIVNNIHNKPRDKILSDVLAKFSAAIQNNPTDTIVIIEQPELLLSLVSGLTCSELNNKFITPLLRQCKVLIIVSNSDIFNIDEYDASVHSSNLQNFYKSSFIKSMINLNLNPLKTGFAKDVTGSLHVCRGGAPIATSNTSLHVVENEYLYLNEKESTKLFYR
Protein: Probable flagellar assembly protein FliH (P23449)
Organism: Bacillus subtilis (strain 168)
Function: Needed for flagellar regrowth and assembly.
Interaction partners:
- Flagellar motor switch protein FliG
- Flagellar motor switch protein FliM
- Flagellum-specific ATP synthase
- Flagellar FliJ protein
- Flagellar motor switch phosphatase FliY
- Flagellar M-ring protein
- Flagellar biosynthetic protein FliP
- FlaA locus uncharacterized protein YlxG
- Flagellar hook-basal body complex protein FliE
- Probable flagellar hook-length control protein
Sequence:
MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEAKAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAKKVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECRLGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE
Protein: Mucin-13 (MUC-13) (P97881)
Organism: Rattus norvegicus (Rat)
Function: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000250}. Note=Also exists as a soluble form. {ECO:0000250}.
Interaction partners:
- Mucin 15, cell surface associated
- Mucin-1
- Mucin 20, cell surface associated
- Mucin 6, oligomeric mucus/gel-forming.
- Mucin-2
- Mucin-2
- Uncharacterized protein.
- Mucin-2
- Krev interaction trapped protein 1
Sequence:
MSQSSGGTSTPTTTATQPTSTSTQTPGTTQLLSTTSTPTTTATQPTSTSTQTPGTTQLPSTTSTPTTTATQPTXTSTQTPGTTQLPGTTSTPTTTATQPTSTSFQTPGTTQLPSSTSTPTTTATQPTSTASQTPGTTQPPGGASSPTTTVTQPTGSSSQTPGTTQPPGGASTPTTTVTQPTGSSSQTSGTTQPPGGASSSTVTSSSSTGSNDPCNSNPCKSPASCVKLYDSYFCLCLEGYYYNNSSSCVKGTTFPGEIGMSVNETTDLEDKNSVNYQTLHSSVVKFFENTFKKTDYGQTVILKVSKDSLMSSRSVMRAATQTVYVSVVNMFGENTKEDEESVASVIKEAVKTDNNVERYFQQDRCDYYGCVKSGSNVCRNGLQCTCKPGLERLNPQVPFCVAPTCSEPCSAEKKQLCLKKDNGAMECGCMAGYRKANGKCEECPFGYSGMDCKDQFQLILTIVGTIAGAFILILLIVFIVSMRSKNKKKSGEEQNLIEDDFHNLRMRPTGFSNFGADTSIFPKVKTGVPSQTSNPYANHRSMPRPDY
Protein: MOT48 protein (D4AHU0)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Interaction partners:
Sequence:
MLITDNMLGKQEPQAVGPMDGPEPSPEELLALVELLQQQGMNMDQVPADLKTMLHNVKRQKAPATKGPATPEAPTEEITPDPGFVIKTTETKTGDKIFINVCWHDRVAAPGGWSNGVMPDEVAAALEKLQSAGGDEGAAHMSPSEVEALRFPLACGAPRVDTDRKGSPCTAIDVVFNSDVVRAAASARKLKAMLIEVSLGWVGNKLGGKLDPRYKLPKMRYKGEVVASQRIRADDKRKKLVTELREVDEEPSFALRTKKAPAPPPITAQSPASAASSTVAAPATASSADQQSVAAVGPASNHDRSSGAAASPSAAPTYKVDYAGRPVQWVQVTVDFPASGPSSSAAAQQPGCTSVEVCGRNVYIRAGPGAPELHVPLQFAVSAEGATAAWQEQQQPSTGGGKGPGGPLGQHLVVRLPYMGLQDYLADARAQAPLAFGQLSFASKALLELEP
Protein: DNA replication complex GINS protein PSF2 (GINS complex subunit 2) (Q9Y248)
Organism: Homo sapiens (Human)
Function: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- DNA replication complex GINS protein SLD5
- Cell division control protein 45 homolog
- DNA replication complex GINS protein PSF3
- DNA replication licensing factor MCM3
- DNA replication complex GINS protein PSF1
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM6
Sequence:
MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLESTQSQDF
Protein: Epsin, putative (Q387I4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Clathrin heavy chain
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Clathrin coat assembly protein, putative
- AP-1 complex subunit gamma
Sequence:
MSFPTSLHAAKEMLRMKTSGNEYARLVHEATNEDPWGPTGEQMDNVCRVFQAGTVKIMEEIKLRLKNRDKSWRPCYKALLLLDHLARNVPEVGLPPLCSILPTLQHISQTFYYTGKQGADHGLSVRERAKKLFDLLSDPATLRDERYKAAATRAKLSGESIGSNMYGGFGSSQFQGGSNATQPSNTFQHASTTSYTISREQQEQEDRELAARMQCEEERRAGITVSEAQRMLGLERRSNAAKEASEKADMELAKRLEEEERRRAFGGVGAAPSEIKATAPPEDNISSNAVEAHPKAEPRHDMLDDLFASAPAVPVTATAPPSAFSMPAQQQAASVDPFGGFTSNNAQQLQTHQQWPQQQQQWPQQQQQWPQQQQQQWPQQPSQTQFPYANSQPLAAPLQQPAGVPSGGGWYNMPPTAQQTQSPPLSQAMPTAQSGMWSSGAPHSAVGMGMGAPQGYAPFDNMGTGVTQLNTMEQQIAQFAGQNSGFPQPSSTSLDGIMAGRRLGQ
Protein: Zinc fingers and homeoboxes 3 (H0Y6F5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
XAKALPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQAALPGHVVGQPEGTGGGLLVTQPLMANGLQATSSPLPLTVTSVPKQPGVAPINTVCSNTTSAVKVVNAAQSLLTACPSITSQAFLDASIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGSRAMIPGDHSSIIIDSVPEVSFSPSSKVPEVTCIPTTATLATHPSAKRQSWHQTPDFTPTKYKERAPEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKKVNAEETKKAEENASQEEEEAAEDEGGEEDLASELRVSGENGSLEMPSSHILAERKVSPIKINLKNLRVTEANGRNEIPGLGACDPEDDESNKLAEQLPGKVSCKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEKMGEETRAVADTGSEDQGPGTGELTAVHKGMGDTYSEVSENSESWEPRVPEASSEPFDTSSPQAGRQLGSWSLSSQPLPSLLTL
Protein: Dilute domain-containing protein (Q8I7K3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDLNDKLTRQSEELAEARAQLRGYSGPLGLENASDEEIIRLEAFEKGSIKHSGFLEVYNVPEFARIIVCELKPTLARLLTKNLPAYLLVAAFRNHDEKRDETALTGLFSSVHLVLKDTISRSHDLDLLSLWLVNLWRLFNLLRQYSGEDSQPEWHVANTETQNSYRFKAYDVAPIRDQLKLRIEECYTSLMKKAIEHVLSPKIVPGILQHESSSDLMTAGQERRDRNSGSVESQRKSLDDLLQFMEIVHTKLTTYGGDDIVVKQVIGQMARWMCALALNYMMFRRELCNFEKAIQIKHNVTQIQNWLNAKGLSDCRDHFEPLVQACHLLQSRKDPSNLDTLCGEMTSRLKPRQVVAILQHYDPSDEMEDGLSPEFLVQIQKKLNERAIANNDPIEDKDKLIMLGTYLPPFDTQPFSYSDFPLETLSLPSCLHMQSVCRLV
Protein: LHFPL tetraspan subfamily member 3 protein (Lipoma HMGIC fusion partner-like 3 protein) (Q86UP9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Neuroligin-2
Sequence:
MPGAAAAAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFAIVNVVCFIQPYWIGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFKAASFFIGLSMMLIIACIICFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFPDGWDSDEVKRMCGEKTDKYTLGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLMAEELKAENKVLLSQYSLE
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (A0A0G2K6N8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Decapping mRNA 2
- Far upstream element-binding protein 2
- Poly
- Symplekin
- Cytoplasmic polyadenylation element-binding protein 1
- polynucleotide adenylyltransferase
- Poly
- Neuroguidin
- Polyadenylate-binding protein 1
- Exosome complex component RRP46
Sequence:
MEIIRSNFKINLPKVYQAIEEADFFAIDGEFSGISDGPSVTALTSGFDTPEERYQKLKKHSMDFLLFQFGLCAFKYDHANSKHVTKSFNFYVFPKPFSRSSPDVKFVCQSSSIDFLASQGFDFNKVFCSGIPYLNQEEERQLREQFDEKRSQANGAGALTKCPVTIPEDQKKFIDQVIEKIEGFLQREEKRTLELNPCTGFQRKLIYQTLSWKYPKGIHVETLETDKKERHIVISKVDEEERKRREQEKYAKEQEELNDAVGFSRVIHAIANSGKLVVGHNMLLDVMHTIHQFYCPLPVDLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFDPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSLLSPPKTCVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVQIAVNTSKYAESYRIQTYAEYVGKKQESKQVKRKWTEDSWKEVDRKRPHVPGPCYHTNRHTRREHQIPFITDGCEPPCGCWQLNSGPLEEQSAL
Protein: rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin) (P22087)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14583623, ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:2026646, ECO:0000269|PubMed:2414294, ECO:0000269|PubMed:24352239, ECO:0000269|PubMed:34516797}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P35550}. Note=Fibrillar region of the nucleolus.
Interaction partners:
- NHP2-like protein 1
- U3 small nucleolar RNA-interacting protein 2
- H/ACA ribonucleoprotein complex subunit DKC1
- Nucleolar protein 56
- Nucleolar protein 58
- WD repeat-containing protein 36
- H/ACA ribonucleoprotein complex subunit 2
- U3 small nucleolar ribonucleoprotein protein MPP10
- Nucleolar protein 6
- Something about silencing protein 10
Sequence:
MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN
Protein: Arabinogalactan O-methyltransferase 1 (EC 2.1.1.-) (Q9C7F9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:31245760}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beta-glucuronosyltransferase GlcAT14B
- Beta-glucuronosyltransferase GlcAT14C
- Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein
Sequence:
MNTLIPSEKRWIITGVLLAGLVGGALLFTSFIRAADETLFLCSTASAKSRAVAAAADYEATPIQLQAIVHYATSNVVPQQNLAEISISFNILKKLAPANFLVFGLGRDSLMWASLNPRGKTLFLEEDLEWFQKVTKDSPFLRAHHVRYRTQLQQADSLLRSYKTEPKCFPAKSYLRGNEKCKLALTGLPDEFYDTEWDLLMVDAPKGYFAEAPGRMAAIFSAAVMARNRKKPGVTHVFLHDVNRRVEKTFAEEFLCRKYRVNAAGRLWHFAIPPAAANATIDSGDYRFC
Protein: Frizzled-4 (Transmembrane receptor LIN-17) (G5EDV1)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein Wnt
- Abnormal cell lineage protein 44
- Protein Wnt-2
- Protein Wnt-1
- Protein mom-2
- DiSHevelled related
- Inactive tyrosine-protein kinase RYK
- DiSHevelled related
- Tyrosine-protein kinase receptor cam-1
- Segment polarity protein dishevelled homolog mig-5
Sequence:
MMHSLGIILLFIPLATGSIFDQAVKGKCIPIDIELCKDLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAPMCPIGMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFPDPPELCMKPTEDEITGGFSAPRLPTKGSSSSSSKPTGCPSDLVDVDPHDPKSHCAFACQSNVMFSTDNKRMVRSWSIWFAAANAGVALFSFLTFAIDRKRFRFPERCVFYLSLCIFISSLPYLTPLFIDAPIRSCHALGNGRSYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASMCRERISFRTRGTDTSKLEKLMVKMGFFCALFILPNVIELVCQCYKFMILTQWTRMTIDCKQQSGACHRPTPPQAEIYMTAVISSLATGFSCLMWVLSAKTVHAWKNFIFCGMCSSAPVKNPIEPSTRPLLEPPTAPPPQPPVYMQMATNPQNSWRPSKVV
Protein: Raptor N-terminal CASPase-like domain-containing protein (G5EF88)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MEEDRSITPFSSFAERLTVNLWHAQRNVERVTLYLQEPRHVEDIAGSMEDEWDCIEECVNRRKGSDRLRTASVAIIMCLHLGVDPPEAPSRKDAPSRLLSWVDPYKCGAHKAAIEIGLSTQRAYEKWQPKSKTRYKICTDPPIDDVRKVATNLRRISGNDRVLFHYNGHGVPKPTDNGEIWVFNKSFTQYIPLSIFDLQGWLDYPTIYIWETHSAETILHNYRRFGEDQKISWQSRFDRWQEEQRNLPPISSKMTDADQAEALGFPEKYPRYNDCIHLAACSAGQWLPMSNPHLPADLFTSCLTTPIRTSLAFHLSHSEHRDEYPENILDMIPGNLAERRTVLGELNWIFTAITDTIAFTSIDRDSFQKLFRQDLLLATLFRSFLLAQRVMSKFNVLPVSQPPLKDTSMHDLWRCWDQTMDMVLDYCRELIYVKECERALFCGRDVINRSNVFPFLVLIDFEHVLTYNETHQYNTFFTEQLQAFELWLDYGVDEGTPPLQLPMVLQVLLSQAHRVRALRLLARFLDFGRWAIGYSLAVGIFPYVLKLLQSNISDLKISLAFIWAKILAVDPSCQMELFNECIDESATQQQSPAQSQQPSVALKPSSMFANHPPPAQLTMDKRALQINTQTGGRFQTNQNQALDMQLQYAQQQAHQRQMDPSGGQHSPNAQPRQPQPQQPQQLQQQPSQQQQQQSRQPQGIMKPTNAQPQEKKTMLRFQYFLQLLGDPEIKPKQKTVAAFVLAQLTSNNFKLAQKELTNKGYMGICTELMVDDTARSVKLLKLWILIGLGRLWSDYDVARWQGIRLMAHDKMILELSDESAEVRAAAVFALGSLLRNSSRSNEHASAVEENLAGELCSQCVFDSSVLVREELIVALQWFVFDFEKRFVKFLLELSNQIKFKLPRKRNSSENLSEQGLDIAAEMPSNHRRPRAPPVNEFMQPSVIRKKMSTSVFSTAVEETVHEDGIGNVYHIAHEAGNRVEQESEDIEYRERAKVQIKHLEAKTFNEAVAKTWLSLLILSLDPIERVARMAQKIVHRVEAGMPEMQANIDNTMAHLSRKMIARKNSKATVEMPRKPVGPSEEVSTLSERIKRNLEVEKESGVSADGIDFTKLNMQKAKEQRKGGKGGQIKKLQDESKVKFQVGSPGDVNQQHKNALSPGSSFTDETQSSELFSKDDSSDDDENKSANDEKDRATTASGKTVKGAFRKSDIMDAALMEFTPRRTKAVPGDFAVKEESKTLRTVIENPIVSTQFVAWCSKVFVEPILHVITLDEEKSEDWEHEDEDEFMPEQFREKIKDIQKQDRKMHEEKRARDKKEGKKEKSQEDVVVTTTTISDWAIHAMEGMLQSADIEGRDFQSCKYDECLWRVKLTHPARSLTTSKLRRCMYASDGRLMTIIRQDTDTRSFRRFDLTASNPFCPSYVSQLILINDMSREMVIACSTNGVVRIWDPYFLGWCDDYEKPPELVSASFPLESQMKISDETNRCLFDWNQQNGKLLCTGTRSVRIWDAHCEKVCHDVMYSPGSKQQTGPGAKLNTNTLPTAMSGNLDEEGNMVAVGYADGRVDYFDMRMANPKAARCNLAPVNMSKQFNDRPPGIMHLRVNRQGFGTELFAGSQDGSIYKLQLRMFKEATPSIVTPWEYGAHSHMFVHEDSRILASAGGGELAIYDVAQNKLMARILPPGEPNSMRRDKNSSTFGLFSSQRKLSQVQMSGRMSSMSSATVGEDRQPKVISLTMHQMRLLTVAGYDDNTVCVYGSPKPGLTGHYENTQGASSPPSQSL
Protein: F-box/WD repeat-containing protein lin-23 (Abnormal cell lineage protein 23) (Q09990)
Organism: Caenorhabditis elegans
Function: Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Beta-catenin/armadillo-related protein 1
- Cullin-1
- F-box domain-containing protein
- Beta-catenin-like protein hmp-2
- Skp1-related protein
- Skp1-related protein
- Armadillo repeat-containing protein wrm-1
- Cullin-3
- RING-box protein 1
- F-box/WD repeat-containing protein sel-10
Sequence:
MSSPHRASTTQQLADLSLTEGEHDEGKPLSIDYLQGHEGLIEEVLKWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQRDFISNLPAHLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKKLIEKNVRSDSLWWGLSEKRQWDKFLNISRDMSVRRICEKFNYDVNIKRDKLDQLILMHVFYSKLYPKIIRDIHNIDNNWKRGNYKMTRINCQSENSKGVYCLQYDDDKIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQYDNRVIISGSSDATVRVWDVETGECIKTLIHHCEAVLHLRFANGIMVTCSKDRSIAVWDMVSPRDITIRRVLVGHRAAVNVVDFDDRYIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYRGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRFDEKRIVSGAYDGKIKVWDLQAALDPRALSSEICLCSLVQHTGRVFRLQFDDFQIVSSSHDDTILIWDFLDAPPSGLPSSTNRATLPELPNQAAVARAQMLFEMAARREIERRDREVVEEPALRPRANAARRHNADIAAAAAAAEAARGAGDNDESSSEEDLDRVDQVNNPNVAGPAPPQPHNQNHRRRQPRPELPVRLMQEMAAFDNMRRQQNNMDHLGGGDVDEEMPDGGP