wanglab/gogpt-training-data huggingface dataset:
Protein: Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Q90413)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane. {ECO:0000250}.
Interaction partners:
- Beta-klotho
- Putative fibroblast growth factor 1
- Fibroblast growth factor 8
- Fibroblast growth factor 17
- Fibroblast growth factor 23
- Fibroblast growth factor
- Fibroblast growth factor
- Fibroblast growth factor
- Fibroblast growth factor
- Insulin
Sequence:
MLSILKVFIAICFMELVCSRSITSGEPRAKDIRVSRHILTPGYPENATVLVGGHVKLVCKLHQPASTRLQWFKKDSNRLGPDGSPVLTALTPLLENLSKVNIFPLVNISLEDAGEYVCKAENSAGQATRSAWVEVLSEVSEEPTEEPSEHLLLELGDVLKLRCDTNRPGAVQWFKSGVRVQHNARIQIRAAVMEIADVTYEDSGVYVCMLRGTKEALRNFTITVADAVGSGDDDDEDNGLDDIGPETENDQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTIRWLKNGREFRGEHRIGGIKLRHQHWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSPHRPILQAGLPKNTTAIVGGDAQFLCKVYSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNMSEVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIIIYASGFLALVMAIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVARLSSSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSISDEYLDLSTPFEQYSPSCEDTSSSCSSDNDSVFTHDALSTEPCLLGYHDVHSRMDLKTTMR
Protein: Collagen alpha-1(XII) chain (P70560)
Organism: Rattus norvegicus (Rat)
Function: Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Collagen alpha-1
- Procollagen C-endopeptidase enhancer 1
- Collagen type IX alpha 3 chain
- Collagen alpha-1
- Collagen type IX alpha 2 chain
- Laminin subunit alpha-2
Sequence:
PGEPGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGTPGSPGVAGPSGKPGKPGDHGRPGQSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMSRFNQMLNQIPNDYHSNRNQPGPPGPPGPPGAAGARGEPGPGGAPGFPGRPGVQGPPGERGLPGEKGERGIGSQGPRGPPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPEPYVPEGGAYLPDREPFIVPVEPERTAEYEDDYGADEPEQQHPDHRRWRRALRPGPGQ
Protein: Protein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease (EC 3.1.-.-) (Schlafen family member 14)] (V9GXG1)
Organism: Mus musculus (Mouse)
Function: Shows no ribosome-associated and endoribonuclease activities.
Subcellular location: [Protein SLFN14]: Nucleus {ECO:0000250|UniProtKB:P0C7P3}.
Interaction partners:
- EF-hand calcium binding domain 3
Sequence:
MPYAEITVNLGKVTLGEENRKKMTNSCLKRHENSSLVQAVCALLNSGGGVIKAEINDKSYSYRCHGLGQDLETSFQKLLPSGSQKHLDYMQQNHDLLIFVKSWSPDASSLPLRICSLRSNLYQRDVTSAINLCANGALELLREKESRAQRGTPRLHSQDHILNRTIQEEEDIKMCALEFLKKDKLNFKEKLSFTESTHVEFKRFTTKKIVPRIKETLAHYVSAFANTQGGYIIIGVDDKSKEVFGCKKEKVNPDSLKTEIKNCIEKLPTYHFCREKPKVNFTTKILKVYQKEALYGFVCVVQVEPFCCVVFAEDPDSWIMENNIVTRLKVQQWVEMMLDIQSDPSSGFPTINDSAHLMTPALSAPRRPAYLTKVLEHKETLQRHFFSVTQENLQFQPESLCKKLFSDHEGLEDLLKAQTHPCSHGIVIFSRSWAGDIGLMREEKVLCDALLVAVGSPLVLYTILTDPSSTGRADYTQNTALQLKRQLQTLGGYPGKICVIPRVIYLASRGSRPDQPPVYYPRPYTLSSKAEVEDLLQGLVLVSLCSRSVLSDQLGCEFFKQCLEEQANTLSRNLQESRELFIHCLPGTRKTALAIKMVEKIKDVFHCKPKEILFVCENDSLRDFVMQQVTCRAVTRRTFMREEFPKIKHIVMDETENFCSRHGDWYVKAKSTTHPKANGAANEHPHHGILWLFLDPFQVRHADGSGLPVPSAQFPRKMITSEIHCAVEIAKVMKDEMKRMQENPPSMGLPDTLATFQEAPYEEAMRAGALPGVCEIKANLTPEQIANYVAEKCHSLFHEGYLPQDIAILYRRREDRGQYKDVLLKAMARGTTEVAFNSAADVCADGIILDSVEQFSGMVRNIVFGLCPESVHSEGVHKLCFASKAIKHLYLLYGGRTAF
Protein: Protein mab-21-like 2 (Q9Y586)
Organism: Homo sapiens (Human)
Function: Required for several aspects of embryonic development including normal development of the eye.
Subcellular location: Nucleus {ECO:0000269|PubMed:25719200}. Cytoplasm {ECO:0000269|PubMed:25719200}. Note=Predominantly localizes to the nucleus, with some cytoplasmic localization (PubMed:25719200). {ECO:0000269|PubMed:25719200}.
Interaction partners:
- Homeobox protein Meis2
- Homeobox protein Meis1
- Pre-B-cell leukemia transcription factor 3
- Pre-B-cell leukemia transcription factor 1
Sequence:
MIAAQAKLVYQLNKYYTERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMIADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFGEAENRLLMGGCRNKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALESAAKQTWRLAREILTNPKSLDKL
Protein: Sorting nexin-8 (Q9Y5X2)
Organism: Homo sapiens (Human)
Function: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:19782049}; Peripheral membrane protein {ECO:0000269|PubMed:19782049}; Cytoplasmic side {ECO:0000269|PubMed:19782049}. Note=Colocalizes with retromer components.
Interaction partners:
- DNA mismatch repair protein Msh3
- Vacuolar protein sorting-associated protein 35
- Sorting nexin-1
- Sorting nexin-3
- Vacuolar protein sorting-associated protein 29
- Sorting nexin-5
- Sorting nexin-32
- Vacuolar protein sorting-associated protein 26A
- Sorting nexin-6
Sequence:
MTGRAMDPLPAAAVGAAAEAEADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGNPLLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHVYLPLTSHILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH
Protein: Cell cycle checkpoint protein RAD1 homolog mrt-2 (EC 3.1.11.2) (G5EC44)
Organism: Caenorhabditis elegans
Function: May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell cycle checkpoint protein hpr-9
- Checkpoint protein
- Homolog of S. Pombe Rad
- Replication factor C subunit 4
- Probable replication factor C subunit 5
- Replication factor C subunit 2
- Ankyrin repeat and LEM domain-containing protein 1 homolog
- Serine/threonine-protein kinase ATM
- Flap endonuclease 1
- DNA repair protein RAD51 homolog
Sequence:
MMELETGQCTIMELKKENVKELAQVFKTVAFKDTGTWHASEAGMKITVDDGSYQLASVFINPAFFSSFKVREEIVSMKISIKSISEFLSISENSSSSVKVSYPGMFQPVKMLVEDADGWVARGNFTTTLADQELDFEFDDAGVLATYLLKTQVLKEIIKDFDDTSRTVRIQFTKNSLCFTTFGDVGETTVSIPSRSLQMESVKCLEEVEFSYLLSLIQRMTTAFILATKLILRVDERGVLSCQFSIDHGEGNASYIEFLTVPADEEE
Protein: L-fuconate dehydratase (FucD) (EC 4.2.1.68) (Q8P3K2)
Organism: Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Function: Plays a role in the catabolism of L-fucose. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. L-fuconate is the preferred substrate with 15-fold lower activity observed for L-galactonate and 8-fold lower activity with D-arabinonate. No activity detected with D-fuconate. Can also catalyze the epimerization of L-talonate and D-ribonate, but at slow rates.
Interaction partners:
- 2-keto-3-deoxy-L-fuconate dehydrogenase
- Amidohydrolase-related domain-containing protein
- L-fucose dehydrogenase
- Dehydratase
- Outer membrane protein assembly factor BamB
- 2-oxo-3-deoxygalactonate kinase
Sequence:
MRTIIALETHDVRFPTSRELDGSDAMNPDPDYSAAYVVLRTDGAEDLAGYGLVFTIGRGNDVQTAAVAALAEHVVGLSVDKVIADLGAFARRLTNDSQLRWLGPEKGVMHMAIGAVINAAWDLAARAANKPLWRFIAELTPEQLVDTIDFRYLSDALTRDEALAILRDAQPQRAARTATLIEQGYPAYTTSPGWLGYSDEKLVRLAKEAVADGFRTIKLKVGANVQDDIRRCRLARAAIGPDIAMAVDANQRWDVGPAIDWMRQLAEFDIAWIEEPTSPDDVLGHAAIRQGITPVPVSTGEHTQNRVVFKQLLQAGAVDLIQIDAARVGGVNENLAILLLAAKFGVRVFPHAGGVGLCELVQHLAMADFVAITGKMEDRAIEFVDHLHQHFLDPVRIQHGRYLAPEVPGFSAEMHPASIAEFSYPDGRFWVEDLAASKAKA
Protein: Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) (Q9NRP7)
Organism: Homo sapiens (Human)
Function: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10806483}. Nucleus {ECO:0000269|PubMed:10806483}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:28543983}. Note=Low levels also present in the nucleus. {ECO:0000269|PubMed:10806483}.
Interaction partners:
- Suppressor of fused homolog
- Kinesin-like protein KIF27
- Zinc finger protein GLI1
- Transcriptional activator GLI3
- Zinc finger protein GLI2
- Protein smoothened
- Kinesin-like protein KIF7
Sequence:
MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM
Protein: Tribbles homolog 2 (TRB-2) (Q92519)
Organism: Homo sapiens (Human)
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=May associate with the cytoskeleton. {ECO:0000250}.
Interaction partners:
- RIB43A-like with coiled-coils protein 2
- E3 ubiquitin-protein ligase COP1
- F-box/WD repeat-containing protein 1A
- E3 ubiquitin-protein ligase TRIM21
- Serine/threonine-protein kinase 40
- Tribbles homolog 1
- Ubiquitin-conjugating enzyme E2 E1
- DET1 homolog
Sequence:
MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN
Protein: DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) (Q9VUQ8)
Organism: Drosophila melanogaster (Fruit fly)
Function: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:26792857}. Note=Predominantly localizes to the nucleus in eye imaginal disk cells. {ECO:0000269|PubMed:26792857}.
Interaction partners:
- Nedd8-conjugating enzyme UbcE2M
- Cullin homolog 1
- Ubiquitin-like protein NEDD8
- RING-box protein 1A
- Cullin 6
- Cullin 3, isoform F
- Cullin-5
- Nedd8-activating enzyme E1 catalytic subunit
- RING-box protein 1B
- Cullin-2
Sequence:
MNKLKSSTHRDKVKKFISLTHTGEQTAIFCLQQNDWKFELASDNYFQNPEYYYRELDRKRIEQLFMRYRDPSDPLKIGSQGVIHFLEDLDLKPDSKLVLIIAWKFHAEVQCEFSRDEFINGMCDLGIDSIDKLKTKLPILEQELNDAGKFKDFYHFTFNYAKDPGQKGIDLEMAIAYWCIVLSGRFKFLDIWCQFLEEKHKRAISRDTWNLLLDFATNIDDRMSNYDSEGAWPVLIDDFVEWCQENDHLKEDSSPASGYQQQSSASSSSQKNISSAYQTSHSTNMNYG
Protein: Trehalose phosphorylase (EC 2.4.1.231) (Trehalose synthase) (TSase) (Q9UV63)
Organism: Pleurotus sajor-caju (Oyster mushroom)
Function: Reversibly catalyzes the synthesis and degradation of trehalose from glucose and alpha-D-glucose 1-phosphate. The equilibrium lies in the direction of trehalose synthesis.
Interaction partners:
Sequence:
MSTPHHQFESKSSTAIRRRLSSSVSSKQRPNIMTTTFASLTPMWAGVAGTLVNNNTQYEIAVTVHDGVYSTDFASVIIPVTPGDTVKNSKDIEAQVLNLIRKFSAEHLCKFLGAGITLALLKECPNLCTRLWLDMDIVPIVFNIKPFHTDSVTRPNIKHRISSTTGSYVPSGSETPTVYVEASHLGDPSHLSPNAAQKLPIPRTLDEQSDSAARKCLMYFGPNNNPRLSIGARNPVTVDAGGKIHLIDDLEEYRMTVGAGTWNAVIKLADELREKKVKIGFFSSTPQGGGVALMRHALIRFLTALDVDVAWYVPNPSPQVFRTTKNNHNILQGVAAPDLRLTQEAKDAFDAWILKNGLRWTAEGGPLAPGGVDVVFIDDPQMPGLIPLIKKVRPEVPIVYRSHIEIRNDLVHVAWSPQEEVWKYLWNNIQLADLFISHPVSKFVPSDVPTEKLALLGAATDWLDGLNKDLDPWDSPFYMGEFRPRGSHLNRGEFRSLCAKEKMHELNWPARDYIVQVARFDPSKGIPNVVDSYYKFRNLLRTRSPDMDESEHPQLLICGHGAVDDPDASIIYDQIMALVNSDPYKEYAHDIVVMRLPPSDELLNAMMANSRIALQLSTREGFEVKVSEALHTGKPVIACRTGGIPLQIQHGKSGYLTTPGEKDAVAGHFYDFYTDEALYRKMSDFARTHVSNEVGTVGNAAAWLYLAVMYSRGEKIKPNGAWINDFFREETGEPYKEGETKLPRTKLDMQG
Protein: Sex-determination protein fem-3 (H2L280)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPQFWNNSQMYNYAATRGQRLVQNIAAFYPPEYFWNEDESKYHTTFVVPRGTEFSKFYARRFHEALGMPPLENEIITVLDWLAKLCILEIVYHTTIWCDITGFGGLPRIEHYRLAMENVEDIIFDLAIDDFSISRLQLQISPFEISRYSPLDVSGYYETIKRKKDIEEYQNRFYEVHYSDDVRIMNVYATDCSRKR
Protein: Polycystin cation channel PKD1/PKD2 domain-containing protein (Q54EY0)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Mechanosensitive ion channel MscS domain-containing protein
- Uncharacterized protein
Sequence:
MTSFKGDRLVVNINDDNDDDSKSSLLEEFKSSNKLDGFHNKKKSNYRRCLDFFKKLLLPVGKMPHEDRLNMDWLQKWRKYNRFPFKLLIHLALTVCLTTTIFLQTGDLTVYSVGIEATWYNIFFPTDFQYEGDYGANIMYLYTINETISMIKDNLEAYNSLEDTSVNRFQVYSPTNGDFSPPYNATMTIASYKHCDQVFDTSLVNANTATETIAYTISSDNLGPFQSYIDSGSGNDNDNDSNSNSNSGNHNSETIQQLFYCMSEMKVKYSFTNVHLQYEHPVAYLWDVYVIFNNIEQAGRIELSIHSEKTRISEPPYGKLLQSSKLILDSFIIVLSILSQILAWRSFVFSFKTYQRTKRLLRRNSTRSLLTVNWKSLSWKTKLRFFNLWFVLCLISNVLTIAGAILDFFEVPGTVSSTATKVLIGLGTLLSWINMIRYLEFDTKSTSLIRALINGLPEIIRFSAGSLPIFIGFCLFGLMVFSEHTLRFASFGEAAITLFGLQNGDDVQATFRATEKDPIISKMYFFVFVFISVYCISNIYIAIMESSYSRSIGIKSKLEKKAKEKKKLKEQYGDEINLDDHLWKTLLGLKEEKLDDDDPNSNFNDDDDDDDDDDQSQSNLLNDDDYDDNDDDLDDNNNNPNNNNSNNNNNNNNNNNNNKNDDDTSSNISGIQMISSSKKDKKVKKSKKSKSPPLPPSKPHSQINLTESQIIETDRAVSTFDTNAIIEDISKVIFERQLAFNKEIQNLIKNSIQQRLQDLVENRQISINNQQSDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNK
Protein: Sarcalumenin (Q86TD4)
Organism: Homo sapiens (Human)
Subcellular location: Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P13666}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13666}; Peripheral membrane protein {ECO:0000250|UniProtKB:P13666}. Note=May associate with the sarcoplasmic reticulum membrane, via a calcium-dependent mechanism. {ECO:0000250|UniProtKB:P13666}.
Interaction partners:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
- Calsequestrin-1
- Myosin light chain 1/3, skeletal muscle isoform
- Ryanodine receptor 1
Sequence:
MRALVLLGCLLASLLFSGQAEETEDANEEAPLRDRSHIEKTLMLNEDKPSDDYSAVLQRLRKIYHSSIKPLEQSYKYNELRQHEITDGEITSKPMVLFLGPWSVGKSTMINYLLGLENTRYQLYTGAEPTTSEFTVLMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPGIIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEMLFRQLKGRESQIRIILNKADNLATQMLMRVYGALFWSLAPLINVTEPPRVYVSSFWPQEYKPDTHQELFLQEEISLLEDLNQVIENRLENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFKDIVEDPDKFYIFKTILAKTNVSKFDLPNREAYKDFFGINPISSFKLLSQQCSYMGGCFLEKIERAITQELPGLLGSLGLGKNPGALNCDKTGCSETPKNRYRKH
Protein: Nuclear matrix constituent protein 1a (OsNMCP1a) (Q0DY81)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Architectural component of nuclear structure that plays different roles in controlling nuclear size and morphology.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:15659629}. Nucleus lamina {ECO:0000269|PubMed:15659629}. Note=Forms aggregated foci in the inner nuclear matrix region (PubMed:15659629). Localizes in the nuclear periphery (PubMed:15659629). {ECO:0000269|PubMed:15659629}.
Interaction partners:
Sequence:
MFTPQGKGWTGWSTPAPANQRSGGGAPAASAPLGKGKGTTLRVAELEQELHEYQYNMGLLLIEKKEWTAKLDEINQALTQKEEILKREQAAHLNAISEYERREESMRKALGVEKQCVTDLEKALREIRGEIAEVKFMSEKKITDAQSLEASLEEKRLEIEGKLHAADAKLAEANRKKSQADRDLEEVEARQRRLEKEKLYFENERKAGEDRIKRQEDSLRDWDKKLKESQNRILDLQRSLNDREERANENDKLFKIKQEELEEAKKALEHTKATLKIKEDDINKRLAELHLQEKEAESKNRKLEEREKKIAEREEKVSAREKVGLQKLLEDHNVKLESKRRDFDLQLENEKKSFDAMLVQKEADLVQREKDVRSSEEKLSKKEQVLNESKKKLEEWQNDLDTKSNALKKWEESLQNDEKQLSEQKLQIENERKQAEMYKLELESLKATVVAEKEKILQEQNNLKLTEEERQEHIMLTAQLKKEIDEYRMRSNSLSEETEDLRKQRQKFEEEWEQLDEKRTHLEEEAKKLNNEKKNLERWHDNEEKRLKDREDELDIKYKEQGENLALKEKSLIDNIDHQRLENEELLKRERADLQRNLQLHRHELEMEMEKKQASKERELEEKENELNRKMDFVENELKRAAELNESKIQKILLEKKQLQKEKEVLVEDRQKLETDKADIRRDIDSLNTLSKSLKERREAYNRDRNNLIDIFEKYKVCKNCGVIIFEGLDALALKDSTDIEYPSLAVEADDRSPNPDTLAQETGALVNSGGRLSLLQKCSRIFKFSPRKKAEQSSEQQAVKNTDFGARLEEASQSDDDYEPTPVYQVAYNSFDAEDLPSESGAFENEESERQDIADDVQMESSLGVADNCVDIHGTQSFDGNTDMVVDTTIVDVDQNGKDSAVLPVVDLEPETSKQGRRQQNRKGRAKGGVKRTRSVLAVVEDAKEILGENLEVKKDDGQGDSVTVGGTRKRRFAGATISEQDEDSEAHSESVSLGGQRRKRRQTAAAVTQAPGEKRYNLRRTTVANAATAAQTNKKKAAKKGSKQTVEATADDTEGTSKAEEPATGSKGASQSADDASQLPEYSQAEAGDTHGPVEVTSAEGVDIVDGIDAAPDAMPMTPSGSELGAEQDDEEDDDSERRNQSIGKKLWSFFTT
Protein: Uridine phosphorylase 1 (C9JIP2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIG
Protein: MGC174152 protein (A8E587)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMFALLVTLCISAVFAASSIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRHAMNGYKHDPNQTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPRGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM
Protein: Neither inactivation nor afterpotential D, isoform B (M9MRL5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MCCSCCGVTQQKAWVFGLGTFFAVSGLLAIICWPGFIDSGIMKALPLTPTSKTFEKWEELPIPVYVYMYLWNWTNAADVQANGVKPIFAQLGPYVYREERKKMDLEWHDNGTVTFNPRRTWFWEEELSGGKQTDLITAPHLPSLAASNQMRNSNVFLKFMFNEALNANGGHLFVTHTAAEWLFESFYDEFLHYAMTLNNPLVPKIESDHFAWFLNRNGSKDFEGPFTVHTGVGDIKEMGEIKYWKGQNHTGWYDGECGRLNGSTTDLFVPDEPKEKALTIFIPDTCRIINLEFTGQSETIQGITGWKYEITPNTFDNGQINGNAKCWCPLERQPDNCPATGATDLGPCADGVPMYLSADHFMYADESYGSTISGYNPNYDQNNFYIIMERKMGVPLKVNANVMITLYIEPDSVIE
Protein: Mitochondrial protein import protein ZIM17 (Mitochondrial import inner membrane translocase subunit TIM15) (mtHsp70 escort protein 1) (mtHsp70-associated motor and chaperone protein TIM15/ZIM17) (MMC) (P42844)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15383543, ECO:0000269|PubMed:15642367, ECO:0000269|PubMed:15719019, ECO:0000269|PubMed:15992824}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15383543, ECO:0000269|PubMed:15642367, ECO:0000269|PubMed:15719019, ECO:0000269|PubMed:15992824}; Matrix side {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15383543, ECO:0000269|PubMed:15642367, ECO:0000269|PubMed:15719019, ECO:0000269|PubMed:15992824}. Note=Soluble matrix protein loosely associated with the inner membrane.
Interaction partners:
- Import motor subunit, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM44
- GrpE protein homolog
- Presequence translocated-associated motor subunit PAM17
- DnaJ homolog 1
- Intron-encoded endonuclease I-SceI
- Intron-encoded DNA endonuclease aI4
- Mitochondrial import inner membrane translocase subunit TIM50
Sequence:
MIPRTRTLLQSKIPITRYFARCWAPRVRYNVCRTLPAAALHTNIIAHNEVKKDDKKVHLGSFKVDKPKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPHCKVRHLIADHLKIFHDHHVTVEQLMKANGEQVSQDVGDLEFEDIPDSLKDVLGKYAKNNSENASQLPHPSQK
Protein: Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (P46282)
Organism: Bos taurus (Bovine)
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-12 subunit alpha
- Interleukin-12 receptor subunit beta-1
- Interleukin-23 subunit alpha
- Interleukin-23 receptor
- Interleukin-12 receptor subunit beta-2
- Interleukin-2 receptor subunit alpha
- Interferon gamma receptor 1
- Interferon gamma receptor 2
- Interleukin-6 receptor subunit alpha
- Interleukin-27 receptor subunit alpha
Sequence:
MHPQQLVVSWFSLVLLASPIVAMWELEKNVYVVELDWYPDAPGETVVLTCDTPEEDGITWTSDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEALSRSLLLLHKKEDGIWSTDILKDQKEPKAKSFLKCEAKDYSGHFTCWWLTAISTDLKFSVKSSRGSSDPRGVTCGAALLSAEKVSLEHREYNKYTVECQEGSACPAAEESLLIEVVVEAVHKLKYENYTSSFFIRDIIKPDPPKNLQLRPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKNKREKKLFMDQTSAKVTCHKDANVRVQARDRYYSSFWSEWASVSCS