wanglab/gogpt-training-data huggingface dataset:
Protein: Zormin (Q7Z1Y4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MERRQALDSSMSSLYSVASSSNPNPRQPHTGHQLQTQQSQQSQQSQLDAFNYSATMSSSSPTPSQAMSTAMSTGTGTGTGTTHTTPPSSSSLRATTIGTVVVRCGPIQLVIALLQSPEKIYIKVVELEPKITALGENLDESLRMQREHDETLRNLQSLPGPMDEFVQKADKLLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFPDKMTQCFRKMDQLELACEETLHPPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQLEELEKLETLDTRPEHIKRDATRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCLALALLGRELVDLEAALQQARMELNTMYSLGECEHTANEMLTKYREWKQQALLLRDRALKITRAKEKVQSAGHFTEEDACARAYAVLSGCTEHLDLVDQREHWLHQSREFFAKAEHTVSVLEKLELELTSVKLPPHSPESYAMFSKVDRDVRNFTEEPLRLGYGILDEVGRTQPETQGVKRVLDELENRKVYIQGICANSSEDQQKVQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLLQHHELMQDLEIKGELINLLLESIKVHLESLSPQERYDVDSKAESLHKHWIELKDLVLKRVDYVSLLIDFFELANELSSQLDNLQRQLQQTPDEHKLQFLQATWTGIASTFGELKSRGQRFINLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKREVEYLLEKVMSDNEETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQDEIQQRIQTTLGIQTKDQPSLAKIEQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRREIDDYFARQQKEPASGADRSIAEHEKFRDQCMDKFRSLITQSELLIDRVRVLEPPGAREIDTDRILKLLENLRLHFESNSSARMSTLERLEKIEQFRSDLEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTIELLEKRIEKFTESTSQQLFITNPESERYVKDELRKLNEKWQSFKDQVKQKRKSLNQATDFFEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDIENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQSFIKLKMDINVVQERLKQEQRQKEQRERDARDQAEREKAIKEAEAKERLHREEQSRLENQRQQAAIEQAQRELAARELALREQAVREEEARLQAIREQATREQLAREQAAREEELRIQSLRDIARREEEVRLQNIRDEETRIRREEEERIRRENESRSKREEEARIQREEITRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRYASPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFDKGICRLVIEETFAADSARFSCRASNLVGTCDTNATLSVRENAAEVQLVPPRILRFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVFLEDDAVYTCSASNPAGIEHCSASLIVEPLEPTELPSFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHNGKPFQPRDSKYEYGRVTLIIPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETSDSEMASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQGDRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFERLLSDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKLILNNVSGDDKGVYTVKVTNPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIERHQCPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHWFFNDQPVHGHNFLVSTSGERQVLTIQKLTHDAVGKISCVAENEAGKATCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSFSFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKVEKNGGQLFEDAHTRISNKCNRVTIELKQVGVGDAGRYAVTASNTVGQSTSTADLVVKKTIFPPVFGRRLQAQVSKKGEKLTMEVEVTGLPEPTVTWLKDDKPLKDAGISEHRLLAQGNSYRLIIEKAQTTDSGKYMVRATNAGGEAKSIADCAILEPSPERLQEVVKTIVYETGPVAPASEFKTEGYKYTSSSMTSNYSHNMQSSSSSSHHETKFSSTSAPPPVVTYPSPIPAQRKTPAAEFSDYSSEIDERFRSVSRANESDAEIKGYRVVFPPTPTPRTNIATNGHKSPVVVITPSPMEFEPTPQDYARPKFEPISKEIRHEIKTETSSKQSKFMQNQQQNQPVFKPKPVAAKFIAATQQQQQKQPQATSRPTMYYNAVAGAPMHVAKVATETKNVMQMHESTESSQRVVNMQQTKRIIHFDSPQEQRDQQILEPFPYSPATSRTPSRQSHLPPPATPTKFVPGEFRESDYESEIDGARIQPLWSPYGDGMTKGFRRVAPPQGAGRSCSLPRTYERVLSPMEFDRGPEMPSKIHVDINTLRKEQRGGSTVTTQNRTQSLNRNTTMRQQQQQQQQQSMDQIDRAGTLPRYGYSSLQQQAENQGRRMGSTFLQKSHQFVDDVSREIRSSASNGIRPGFKRAPSEGSSQQPQAFRDESRVSQYVPELPNTEPVNAHLSRDELAQRQPLFITPLKDIAVGVGGTARFECIVQAHPQPQVNWTHNGGLLESGSRHCIEYRNGVCRLTLPQAYPDDNGSYACTAINPLGAATTSGNLTVSSTNRGFRY
Protein: Probable conserved membrane protein (O53572)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Large ribosomal subunit protein bL33B
- DUF3499 domain-containing protein
- Carbonic anhydrase 2
- Adenine DNA glycosylase
Sequence:
MLDLEPRGPLPTEIYWRRRGLALGIAVVVVGIAVAIVIAFVDSSAGAKPVSADKPASAQSHPGSPAPQAPQPAGQTEGNAAAAPPQGQNPETPTPTAAVQPPPVLKEGDDCPDSTLAVKGLTNAPQYYVGDQPKFTMVVTNIGLVSCKRDVGAAVLAAYVYSLDNKRLWSNLDCAPSNETLVKTFSPGEQVTTAVTWTGMGSAPRCPLPRPAIGPGTYNLVVQLGNLRSLPVPFILNQPPPPPGPVPAPGPAQAPPPESPAQGG
Protein: Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK) (O31749)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the reversible phosphorylation of UMP to UDP, with ATP or dATP as the most efficient phosphate donors. Is also able to phosphorylate 5-fluoro-UMP and 6-aza-UMP.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15018105}. Note=Is predominantly localized near the bacterial membranes.
Interaction partners:
- Ribosome-recycling factor
- Elongation factor Ts
- Small ribosomal subunit protein uS2
- Uracil phosphoribosyltransferase
- Uridine kinase
- Orotidine 5'-phosphate decarboxylase
- Bifunctional protein PyrR
- Nucleoside diphosphate kinase
- Trifunctional nucleotide phosphoesterase protein YfkN
- CTP synthase
Sequence:
MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKRAVIGESIGTIVRGK
Protein: Nopp140, isoform F (M9MSM4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTDLLKIADAIVLEYLQSKDKNLAKVFQQKTKAASVAKSSPKLSEILQFYQTKSPKKIPAIKATAGDSSEDSDSDSESDAAPKKPATAPALTNGKAVKKAASSTSEDSDSEEEKKPAAKATPAKAVGKKAKSSSEDSSSEEEAPKKAAPVKAPPAKAAPAKKVESSSEDSSSEEEPAKPAVKATTTKVAPAKKADSSSEESSSDEETKPAAKPVAKAAPAKKAASSSEESDSDDEPAAKKPAVQPAAKPAPKAAASSSEDSSSEEEVKPAAKSAAKLAPAKKGASSSDDSSSEDEAPKKAATLAKPISKAAPTKKADSSTEDSSSEDDAPKKVAPAKATPAKAIPAKKAASSDDSSSEEEAPKKAAPANATPARAPPAKKAASSDDSSSEEEAPKKAAPAKATPAKATPAKKAASSDDSSSEEEAPKKAAAPAKATPAKKAKSSSEDSDSDEEEAPKKPAAKAVAKAASSEDSDSSEDEKPAKAAPKALAKSAKAASSDSDDSSDEETPAVKPAVKKTAAPAKKADSSSDESDSGEESGEVKPNSATNGNEKTAQKRKFSGGDQDEATPNKKYNNFVKSGEQQNDFTSTPNNTFSRNHNMNNSGGGSGRRSPFRRVRTEDVVVDSRVQDMSFEAKKNAAGSWGERANKDLKHTRGKSFKHEKTKKKRGSYRGGQIDVGVNSIKFD
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9VP20)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RING-type E3 ubiquitin transferase
- RAC serine/threonine-protein kinase
Sequence:
MSAVTSSDTAISGMALGRSQTICRYYVRGICRFGELCRFSHDLSRGRPECEEQVATDVLPKPSTSSSSTIGSRSASISSQQRNWANAPVFVPSQKRYTAHEQSEFETTVDPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDYGEENSSCAWGEFSAYPIHMELCEMCDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKAGREKRFGILPNCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLNDYRAALGAKDCKYFKKGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRKLQSQNEIIDLLDIYLWDYVDRRDYHWLEMISSDITSSESSDYSDED
Protein: Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122) (P16297)
Organism: Mus musculus (Mouse)
Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P14784}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P14784}.
Interaction partners:
- Cytokine receptor common subunit gamma
- Tyrosine-protein kinase JAK1
- Interleukin-15
- Interleukin-2
- Interleukin-2 receptor subunit alpha
- Interleukin-15 receptor subunit alpha
- Tyrosine-protein kinase JAK3
- Signal transducer and activator of transcription
- SHC-transforming protein 1
- Signal transducer and activator of transcription 3
Sequence:
MATIALPWSLSLYVFLLLLATPWASAAVKNCSHLECFYNSRANVSCMWSHEEALNVTTCHVHAKSNLRHWNKTCELTLVRQASWACNLILGSFPESQSLTSVDLLDINVVCWEEKGWRRVKTCDFHPFDNLRLVAPHSLQVLHIDTQRCNISWKVSQVSHYIEPYLEFEARRRLLGHSWEDASVLSLKQRQQWLFLEMLIPSTSYEVQVRVKAQRNNTGTWSPWSQPLTFRTRPADPMKEILPMSWLRYLLLVLGCFSGFFSCVYILVKCRYLGPWLKTVLKCHIPDPSEFFSQLSSQHGGDLQKWLSSPVPLSFFSPSGPAPEISPLEVLDGDSKAVQLLLLQKDSAPLPSPSGHSQASCFTNQGYFFFHLPNALEIESCQVYFTYDPCVEEEVEEDGSRLPEGSPHPPLLPLAGEQDDYCAFPPRDDLLLFSPSLSTPNTAYGGSRAPEERSPLSLHEGLPSLASRDLMGLQRPLERMPEGDGEGLSANSSGEQASVPEGNLHGQDQDRGQGPILTLNTDAYLSLQELQAQDSVHLI
Protein: Matrix protein (M protein) (O57299)
Organism: Sendai virus (strain Ohita) (SeV)
Function: Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane and concentrates the HN and F glycoproteins. Acts as a negative regulator for transcription and replication by sticking to the nucleocapsid. This effect might be regulated by the cytoplasmic interaction with tubulin that dissociates the M protein from the nucleocapsid (By similarity).
Subcellular location: Virion {ECO:0000305}. Host cytoplasm {ECO:0000250}. Host cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=During bud formation, associates at the inner side of the plasma membrane of infected cells. {ECO:0000250}.
Interaction partners:
Sequence:
MADIYRFPKFSYEDNGTVEPLPLRTGPDKKAIPHIRIVKVGDPPKHGVRYLDLLLLGFFETPKQTASLGSVSDLTEHTGYSICGSGSLPIGVAKYHGSDQELLKACTDLRITVRRTVRAGEMIVYMVDSIGAPLLPWSGRLRQGMIFNANKVALAPQCLPVDKDIRFRVVFVNGTSLGAITIAKIPKTLADLALPNSISVNLLVTLKTGISTEQKGVLPVLDDQGEKKLNFMVHLGLIRRKVGKIYSVEYCKSKIERMRLIFSLGLIGGISFHVQVTGTLSKTFMGQLAWKRAVCFPLMDVNPHMNLVIWAASVEITDVDAVFQPAIPRDFRYYPNVVAKNIGRIRKL
Protein: 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type I DHQase) (Type I dehydroquinase) (DHQ1) (P63588)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Interaction partners:
Sequence:
MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQVAPAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKDVFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNYTRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKIREILDEA
Protein: Mid1-interacting protein 1-like (Gastrulation-specific protein G12-like) (Q8AWD1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in stabilization of microtubules. May play a role in the regulation of lipogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:Q9CQ20}.
Interaction partners:
- DNA-directed RNA polymerase subunit
- Mid1-interacting protein 1-B
- Midline 1.
Sequence:
MMQLSNDSHCNKHSLLNVMNRFIAAANNMDETIMVPNLLRDVPLEDQESHASVSHNNNNNNEPSFPNKQRDMYEHYLLLKSIKNDMEWGLLKREMAGGASFLEMAVKQEELPQMKGEAVEEGPDLEGQFHYHLHGLFSVLSKLTVQADHLTNRYKREIGGGSLLR
Protein: Transcription factor S1 (TFS1) (Transcript cleavage factor TFS1) (Q980K2)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Induces RNA cleavage activity in the RNA polymerase. Induces rapid cleavage of a stalled transcription elongation complex with a 2-nucleotide reduction at the 3' end of the nascent RNA. Truncated RNA is able to resume elongation. During transcription elongation it enhances processivity. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS1 is able to induce a cleavage resynthesis cycle in stalled elongation complexes (resulting from the next missing nucleotide or a reduced incorporation rate of a wrong nucleotide) preventing misincorporation and enabling proofreading in a post-incorporation manner. Pausing of elongation complexes is the main determinant of TFS-induced RNA cleavage (By similarity).
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo11
- DNA-directed RNA polymerase, putative subunit M
- DNA-directed RNA polymerase subunit Rpo6
- Large ribosomal subunit protein uL16
- DNA-directed RNA polymerase subunit Rpo10
- TATA-box-binding protein
- DNA-directed RNA polymerase subunit Rpo1N
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase, subunit B''
Sequence:
MIVVKFCPKCNSMMVPKKSNGKNVYRCTKCGYEKEVPETTIVVTSKVKHSIKEKTLVLEEEEMPSGAQKIKGVLCPSCKNDEAYFWILQTRRADEPPTRFYKCTKCGKVWREYE
Protein: Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D) (Q62645)
Organism: Rattus norvegicus (Rat)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21522138, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:7512349}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 3B
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 3A
- Disks large homolog 4
- Glutamate receptor ionotropic, kainate 4
- Glutamate receptor ionotropic, kainate 5
- Glutamate receptor 4
Sequence:
MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAVGGGTGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRTQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAAIADGFHRYYGPIEPQGLGLGEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPTEPPAGAFPGFPSPPAPPAAAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAAPPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDFPPPAPTSRSLEDLSSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV
Protein: Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2) (P15659)
Organism: Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Function: Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04063}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04063}. Note=PB1 and PA are transported in the host nucleus as a complex. {ECO:0000250|UniProtKB:P03433, ECO:0000255|HAMAP-Rule:MF_04063}.
Interaction partners:
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFIDEQGESIVVELGDPNALLKHRFEIIEGRDRTIAWTVINSICNTTGAEKPKFLPDLYDYKKNRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKSTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDSSWIELDEIGEDAAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEVGDMLLRSAIGHVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPVGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
Protein: Homeobox-leucine zipper protein ATHB-23 (HD-ZIP protein ATHB-23) (Homeodomain transcription factor ATHB-23) (Q8LFD3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable transcription factor At1g11510
- At4g31270
- Ubinuclein-1
- TLC domain-containing protein At5g14285
- Transcriptional adapter ADA2a
- Homeobox protein SHOOT MERISTEMLESS
- Homeobox-leucine zipper protein HDG7
- Homeobox protein knotted-1-like 5
Sequence:
MSCNNNGLAFFPENFSLQNHHQEEEDHPQLLQDFHGFLGKRSPMNNVQGFCNLDMNGDEEYSDDGSKMGEKKRRLNMEQLKALEKDFELGNKLESDRKLELARALGLQPRQIAIWFQNRRARSKTKQLEKDYDMLKRQFESLRDENEVLQTQNQKLQAQVMALKSREPIESINLNKETEGSCSDRSENISGDIRPPEIDSQFALGHPPTTTTMQFFQNSSSEQRMVKEENSISNMFCGIDDQSGFWPWLDQQQYN
Protein: Pre-mRNA-splicing factor ISY1 homolog (Q9ULR0)
Organism: Homo sapiens (Human)
Function: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome.
Subcellular location: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:29301961}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8
- Splicing factor YJU2
- Pre-mRNA-splicing factor SYF1
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Crooked neck-like protein 1
- Pre-mRNA-splicing factor CWC25 homolog
- Pre-mRNA-splicing factor CWC22 homolog
- Pleiotropic regulator 1
- Pre-mRNA-processing factor 19
- Cell division cycle 5-like protein
Sequence:
MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLLGY
Protein: Tachykinin-like peptides receptor 86C (NKD) (P30974)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for tachykinin-like peptides.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1370464}; Multi-pass membrane protein {ECO:0000269|PubMed:1370464}.
Interaction partners:
- Natalisin, isoform D
Sequence:
MSEIVDTELLVNCTILAVRRFELNSIVNTTLLGSLNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRAETKSQWKRSTMETQIQQAPVTSSCREQRSAQQQQPPGSGTNRAAVECIMERPADGSSSPLCLSINNSIGERQRVKIKYISCDEDNNPVELSPKQM
Protein: Lysophosphatidylcholine acyltransferase 1 (A0A060XS70)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Cardiolipin synthase
- Lysophospholipid acyltransferase 5
- Lysophospholipid acyltransferase 5
- Phospholipid/glycerol acyltransferase domain-containing protein
- Phospholipid/glycerol acyltransferase domain-containing protein
- Phospholipid/glycerol acyltransferase domain-containing protein
- Cholinephosphotransferase 1
- Cholinephosphotransferase 1
- Phospholipid/glycerol acyltransferase domain-containing protein
- Haloacid dehalogenase-like hydrolase domain-containing protein 3
Sequence:
MTAAWSHGVYTCKLLFVQMNVVRSRIWKLLPRMNQTCEGLQCFFLMSFDFSMMSSKEALSLKVGAFIPAVPVQPVVLRYPNKMDTITWTWQGPGAFEILWLTLCQFHNPIEIEYLPLYTPSEEEKNNPALFANNVRHIMAKALELPITDLSFDDCQLSQAKGPLRVPTNSSLLQFNRLARRLGLRTGTTDTVLQQQASRARNIWGYRLGLEDFAQYLDLPVTDMLTELHSLFNQHGDGQIDVREYVIALSVVCQPSKAMDTLRLAFGMYEAKEDRAIVEKELASILRTALGVAEVDVTELFSAIDTLDAGKITHDDFCRFVVQHPDFAQEYLLSSRETPSTPHTVPLTNGFSVDHYNTEEPTCSLPGQKKKDN
Protein: ABC transporter E family member 2 (ABC transporter ABCE.2) (AtABCE2) (RNase L inhibitor-like protein 2) (AtRLI2) (AthaRLI2) (Q8LPJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit E
- ABC transporter F family member 3
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit H
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- ABC transporter F family member 1
- Small ribosomal subunit protein eS30z/eS30y/eS30x
Sequence:
MADRLTRIAIVSSDRCKPKKCRQECKKSCPVVKTGKLCIEVTVGSKLAFISEELCIGCGICVKKCPFEAIQIINLPRDLEKDTTHRYGANTFKLHRLPVPRPGQVLGLVGTNGIGKSTALKILAGKLKPNLGRFTSPPDWQEILTHFRGSELQNYFTRILEDNLKAIIKPQYVDHIPRAVKGNVGEVLDQKDERDKKAELCADLELNQVIDRDVENLSGGELQRFAIAVVAIQNAEIYMFDEPSSYLDVKQRLKAAQVVRSLLRPNSYVIVVEHDLSVLDYLSDFICCLYGKPGAYGVVTLPFSVREGINIFLAGFVPTENLRFRDESLTFKVAETPQESAEEIQSYARYKYPTMTKTQGNFRLRVSEGEFTDSQIIVMLGENGTGKTTFIRMLAGLLKPDDTEGPDREIPEFNVSYKPQKISPKFQNSVRHLLHQKIRDSYMHPQFMSDVMKPLQIEQLMDQEVVNLSGGELQRVALTLCLGKPADIYLIDEPSAYLDSEQRIVASKVIKRFILHAKKTAFVVEHDFIMATYLADRVIVYEGQPSIDCTANCPQSLLSGMNLFLSHLNITFRRDPTNFRPRINKLESTKDREQKSAGSYYYLDD
Protein: Nnf1b (RE44027p) (Q8IPW3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Mis12
- CG1558-RA protein
- Kinetochore protein Spc25
- HDC12388
- Nuf2
- Kinetochore protein NDC80
- Nnf1a
- Spc105-related, isoform B
- Centromeric protein-C, isoform A
Sequence:
MNNIEEDTEAAFKRLQAVIPQVKQAYEEAIGQIFSDLNSSDLESCASILEEHESTSLDTEQIIHSTRRLMTKIVLDVNQCFFSGNDVETKLTTLEMLKEQFAAHEGKNWNFNCLSPEELTRPLRMHNLNLSITFMEQQLKKQEKELEIAMAKSIKNRQLIHDVHAERVKVGCMMKQQLAEYQAIKPQLMEMERLINDSYVQEEM
Protein: Fascin-2 (Retinal fascin) (O14926)
Organism: Homo sapiens (Human)
Function: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}.
Interaction partners:
- Xin actin-binding repeat-containing protein 2
- Plastin-1
- Unconventional myosin-VIIa
- Taperin
- Retinitis pigmentosa 9 protein
- U4/U6 small nuclear ribonucleoprotein Prp31
- Radixin
- Glutaredoxin domain-containing cysteine-rich protein 1
- Twinfilin-1
- Chloride intracellular channel protein 5
Sequence:
MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEPDPGQGTAVLLRSSHLGRYLSAEEDGRVACEAEQPGRDCRFLVLPQPDGRWVLRSEPHGRFFGGTEDQLSCFATAVSPAELWTVHLAIHPQAHLLSVSRRRYVHLCPREDEMAADGDKPWGVDALLTLIFRSRRYCLKSCDSRYLRSDGRLVWEPEPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDDELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIHATATQVSANTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGKDEEFTLKLINRPILVLRGLDGFVCHHRGSNQLDTNRSVYDVFHLSFSDGAYRIRGRDGGFWYTGSHGSVCSDGERAEDFVFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGTALWEY
Protein: Autophagy-related 18a, isoform A (Autophagy-related 18a, isoform B) (Autophagy-related 18a, isoform C) (Autophagy-related 18a, isoform G) (LD38705p) (Q9VSF0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMSLLGRTDVDAGEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLIERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTLPEAGVRRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDIKGA