wanglab/gogpt-training-data huggingface dataset:
Protein: Fibroblast growth factor-binding protein 2b (F1QLT3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Cartilage matrix protein
- Actinodin2
- MIA SH3 domain-containing
- Fibroblast growth factor receptor-like 1
- Fibroblast growth factor
- Carboxypeptidase N, polypeptide 1.
- Carboxypeptidase N, polypeptide 1.
Sequence:
MCTLLNDPFVGLVFIKPDCTSNTSSVHYTFAMRSICSCAFLLVCFIWATDAQNSSNHIEITQHSRPQPQPKANLWDEPIRFNTKAKDTCTMVISSQTNTTKLRVSCKSKGKSYWCDFLGKPNLCKSYNNNPRHYFTQIMWDLRKLHNACQGSRVYKPQMCRSASDEVQMVFHNSWPKNSVPKPTQASQNQQKHQQQVKSSVPPTKPPTKQQLKPQQPAKAASKPAKTGASKPASPRKPVKAITVRPTVAEESQSVKMAEEYCWKSLQGVCAYFISWFQS
Protein: Peroxisomal membrane protein PEX16 (A0A0G2JV14)
Organism: Rattus norvegicus (Rat)
Subcellular location: Peroxisome membrane {ECO:0000256|RuleBase:RU365003}.
Interaction partners:
Sequence:
MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLGSPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVAS
Protein: Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) (O88533)
Organism: Mus musculus (Mouse)
Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
Interaction partners:
- Tyrosine 3-monooxygenase
- Dopamine beta-hydroxylase
- Tryptophan 5-hydroxylase 1
- Amine oxidase [flavin-containing] B
- Catechol O-methyltransferase
- Amine oxidase [flavin-containing] A
- Tryptophan 5-hydroxylase 2
- Transmembrane O-methyltransferase homolog
- Phenylalanine-4-hydroxylase
- Serotonin N-acetyltransferase
Sequence:
MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRPLIPATAPQEPETYEDIIKDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAARTKVIRQLQAASPEFTQAAIMEKLVAYTSDQAHSSVERAGLIGGIKLKAVPSDGNFSMRASALREALERDKAAGLIPFFVVATLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKRRTDLTGAFNMDPVYLKHSHQDSGFITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVELSHEFESLVRQDPRFEICTEVILGLVCFRLKGSNELNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCARTVESAHVQLAWEHISDLASSVLRAEKE
Protein: Glycine betaine/proline betaine transport system ATP-binding protein ProV (P17328)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:P14175}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14175}.
Interaction partners:
- Glycine betaine/proline betaine-binding periplasmic protein
- Glycine betaine/proline betaine transport system permease protein ProW
- Multidrug resistance-like ATP-binding protein MdlA
- Osmoprotectant import permease protein OsmY
- Osmoprotectant import permease protein OsmW
- Cytochrome-related transporter
Sequence:
MAIKLEVKNLYKIFGEHPQRAFKYIEKGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGIAAQERREKALDALRQVGLENYAHAYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRSPVGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGVVSIDSLKAALSQAQGIEAALIDDPLVVDAQTPLSELLSHVGQAPCAVPVVDEEHQYVGIISKRMLLQALDREGGNNG
Protein: Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) (Q16853)
Organism: Homo sapiens (Human)
Function: Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}.
Interaction partners:
- Sialic acid-binding Ig-like lectin 9
- Aldehyde dehydrogenase, mitochondrial
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- Amine oxidase [copper-containing] 2
- Aldehyde dehydrogenase X, mitochondrial
- Alpha-aminoadipic semialdehyde dehydrogenase
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Aldehyde dehydrogenase family 3 member B1
- Aldehyde dehydrogenase family 3 member B2
Sequence:
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
Protein: Pias4 protein (Q4G041)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
RLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECEDADEIEFLAEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGMGSGLSGPGGAGGGAGAAGGLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDDDEGPRPKRRCPFQKGLVPAC
Protein: Pathogenesis-related protein 10 (A0A1D6JZU3)
Organism: Zea mays (Maize)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASTNSWTVEIASPVAAPRLFRAAVMDWHTLAPKVTSHVVASAHPVEGEGGVGSVRQFNFTSAMPFGFVKERLEFLDVDKCECKSTLVEGGGIGVAIETAASHVKVESAAGGGCVVKVDSTYKLLPGVEVQDEITKAKESVTNIFKAAEAYLVANPEAYN
Protein: Mediator of RNA polymerase II transcription subunit 26 (Mediator complex subunit 26) (dARC70) (Q9V4F9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA gene.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 31
Sequence:
MNQIEIQELTTHLSQALDQNYDVVNMDAVLCVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRAKSLLKKWREMVGIQQTATENLAHPSQISSSQPALDLVKSPITSFITEPIAPSQQIVSDLHSNIDSAEPPLSGEHTLLHPNFSNLVNSIKDSDRHENIAITTLHTHKDRRHSHSIRSCHVASPQPIVIDHSVNSVINLTDDSTVKINEASVVIDIASDSDENDNNGSLNPKKLNSIVPAPLPIPSTPSSRQRKLKKEKRSKEREGQVATNTRFGAKASDGFQQAALTTDSEIFSLSNSSMSSIVSGDATSSYSQNKSRLNSNELTFTGRFKAVDHLFRSTESGKHKIDEYSAYDSNASCSRLSPSTVDEVKKAEHLFDAQLTNTTANQIPMSAVSIGYESNTRHEYLESDSPSQIPKRRGRKKGSKGVDALIAKESSSLSQQIFFGGSTVKKVKTTKELFNEIQSRKLSVSMQSSASNLSNSSTNRDLPSHTTFPRQTSSCSDTSMNSPHILETLSGSAIFASKIDDLGNTDSDTVTSDPSHDSNKSQEIKECTSLDSNSNSIQSLPLANNRENLIPTNVNDITTQLMHLIHSLNSPLSEIEIERVYQEKIIPCTCIVIEGVQGTLGESNNSTLDEQSYNAKISLNSKDNLSCHNQDNYSTSQRSVNGEVIDTQPKLVKSIFDLDFDDNDDPLYFIMDEIQKPIARADELKNNKSDTKNINFGASAQNASLNIIHFNDDAQQDNSNQERGKNETQNAIPAFTVHEDPDCLARQRFYIQTNKVTSFHINALHNYYIPNINGNWDSVESFTSFQSEHTIMDTMESYTVTNGADVVPKYGLLTSDRIRKDLSSLKSIKPYRVKNFTSLISPFLGVAKCLPTCRRARRRFKNFVNSSTANDKISNNFESLENMKTSFKNCNPLNVKIDGTTSAIYSHNENHVPMQVNTNVEQLPPSQSFSSNAISYNLLKLADDKVCHDGISDKSSNTGCQGNSPYSSSSSSSYSGRKEDQHIITKNLQNKNIQLNSRKSDMKRRKRIYLENDSKKKKHYRKRIKTAVNRTFSNLHRNLYSIDSENGMKNDYKNEYGNSNNEEYAIVQRPAGDGENCSNHIVLTIKKTPSKINSPANSMTAFSPPSTSDGANLQKSILDLRLEDTNISQSITEIPQKKDLSKTDRIVHQSRSSAYRRIFRKPDKSQTKFIDLDLKHLFHLKANSPCISANAKLHNKLFFPHELSRDNTSGIRERLINYSSSSSSSYDDDSEVENTSFLKKANVNKFSASNNRNLKTETETCAATAISEFKFESDEDSILTSLGDSDIDIQDEIQVINDKVDYCNDFQNNKMLESFNSIFVDSLRTNTKNASDNMGSSAHITSLESLKPENADAITRYCNNNNLGVNLSNELSNISAKPLKSFDSTMKLPSLGIEHCTGIKTSSDMASTNIAEKKLTRIQQFKEWHQVLQLRSYNNEPLIVLPYVLLE
Protein: Probable peptidoglycan biosynthesis protein MviN (P9WJK3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Essential for cell growth and peptidoglycan synthesis.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- FHA domain-containing protein FhaA
- Conserved protein
- Putative mutator protein MutT4
- Pullulanase
- Anti-sigma-M factor RsmA
- N-acetylmuramoyl-L-alanine amidase CwlM
- Serine/threonine-protein kinase PknB
- ECF RNA polymerase sigma factor SigM
- Probable DNA polymerase III subunit delta
- Serine/threonine-protein kinase PknA
Sequence:
MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVAALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKILGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQLIGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSENASFGAASGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETYTRRRRNLLIGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASSAPPGSVVKPTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGVGLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
Protein: Ribosomal protein S7 (Ribosomal protein small subunit 7) (Q2F998)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MGDFDGEQKELIKKLVNFRMIDGKRTRVRAIVYKTFHRLARTERDVIKLMVDAVDNIKPICEVVKVGVAGTIYDVPGIVARDRQQTLAIRWILGAAFKRRISYRISLEKCSFAEILDAYRKRGISRKRRGNLHGLASTNRSFAHFRWW
Protein: Sesquiterpene synthase 1 (TsTPS1) ((4R)-limonene synthase TPS1, mitochondrial) (EC 4.2.3.20) (I7GPX8)
Organism: Toona sinensis (Chinese mahogany) (Cedrela sinensis)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds known for their medicinal efficacy for treating enteritis, dysentery, itch and some cancers. Mediates the conversion of (2E)-geranyl diphosphate (GPP) into (4R)-limonene. Can only use GPP as substrate, no activity with farnesyl diphosphate (FPP).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:23072391}.
Interaction partners:
Sequence:
MASHVLASLRSASARISTRLQSRSCILATATSFSNGFVSASLVQSMSTTTQCDESVARRSANYEPPIWTYDYVQSLRNPYAGGSYAKRIEKLKGDVRVMLQKLVDLDPLHQLEFIDTLQRLGVSYHYQEGIKGILDTVYNNYMQKQESLYAVALGFRLFRQHGYHIPADIFSSFRDDKGNLKSCLGDDCRGILALYEAAHLLVEEERDIFYEIVNFTTAYLKEYVKHDNDEYLSALVNHSLEIPLHWRVLRLEARWFIGAYERAPNTHPILLEFAKLDFNDVQATHQEDLKFMSRWWKNTGLDREKMNFARDRIVQNVLWSLGIIFEPQFAYCRRMSVKAYAFITLIDDVYDVYGTLDELELFTDAVDRWDATAIEKLPDYMKPIFRTLYTSINDMALDARKDRGVDTRPFLHKAWSTLFNYYLMEAKWFSNGYMPTYKEYMDIAWFSVGGPVMIVHSYCAIANPATKENMEFFQEYYDIIRLWSTILRFKDDMGTSSDELKRGDNPKSIQCYMHESGVSEKEARQHLGNLITETWMKVNKNRAENPHLSDVYMGIAINMARMALCMYQFGDGHAVEAHSKDRVLSLLINPIPCP
Protein: Troponin C (Q868D4)
Organism: Lethocerus indicus (Giant water bug)
Interaction partners:
Sequence:
MGDVSKLSSNQVKLLETAFRDFETPEGSGRVSTDQIGIILEVLGIQQTKSTIRQLIDEFDPFGNGDIDFDSFKIIGARFLGEEVNPEQMQQELREAFRLYDKEGNGYISTDVMREILAELDETLSSEDLDAMIDEIDADGSGTVDFEEFMGVMTGGDE
Protein: MDV Eco Q protein (Q69306)
Organism: Infectious laryngotracheitis virus (ILTV) (Gallid herpesvirus 1)
Interaction partners:
Sequence:
MSQEPEPGAMPYSPADDPSPLDLSLGSTSRRKKRKSHDIPNSPSKHPFPDGLSEEEKQKLERRRKRNRDAARRRRRKQTDYVDKLHEACEELQRANEHLRKEIRDLRTECTSLRVQLACHEPVCPMAVPLTVTLGLLTTPHDPVPEPPICTPPPPSPDEPNAPHCSGSQPPICTPPPPDTEELCAQLCSTPPPPISTPHIIYAPGPSPLQPPICTPPPPDAEELCAQLCSTPPPPICTPHSLFCPPQPPSPEGIFPALCPVTEPCTPPSPGTVYAQLCPVGQAPLFTPSPPHPAPEPERLYARLTEDPEQDSLYSGQIYIQFPSDTQSTVWWFPGDGRP
Protein: Discs large 5, isoform C (M9PCQ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKMASGDLSLTSTSSQEEESSEYVGYDNTLRPPSNSSGSTTAANMSNNNGPSKGVSSGVGVSGISGGNGANYDILQAQYKSALLELNTLRHQHANTKRRCDELATELTLYQEHYVADRNKFTDMVEESARFKRLLLETQNQQSQQAQNGNSQVPPVGSGNPYYFGKTQGCDGSCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGDENQKLKVLLSQESKNVLSLTEELNQLLSEKDNVLQEHQKMSDDLVLANKEIERLKKDEQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFPSGKELENSKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAEST
Protein: Chitin biosynthesis protein CHS5 (Protein CAL3) (Q12114)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:9008706}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:9008706}. Note=Trans-Golgi network location requires interaction with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Interaction partners:
- Protein BCH2
- Chitin biosynthesis protein CHS6
- Bud site selection protein 7
- Protein BCH1
- ADP-ribosylation factor 1
- Chitin synthase 3
- Chitin synthase export chaperone
- Chitin synthase regulator SKT5
- Nuclear fusion protein FUS1
- Chitin synthase 1
Sequence:
MSSVDVLLTVGKLDASLALLTTQDHHVIEFPTVLLPENVKAGSIIKMQVSQNLEEEKKQRNHFKSIQAKILEKYGTHKPESPVLKIVNVTQTSCVLAWDPLKLGSAKLKSLILYRKGIRSMVIPNPFKVTTTKISGLSVDTPYEFQLKLITTSGTLWSEKVILRTHKMTDMSGITVCLGPLDPLKEISDLQISQCLSHIGARPLQRHVAIDTTHFVCNDLDNEESNEELIRAKHNNIPIVRPEWVRACEVEKRIVGVRGFYLDADQSILKNYTFPPVNEEELSYSKENEPVAEVADENKMPEDTTDVEQVASPNDNESNPSEAKEQGEKSGHETAPVSPVEDPLHASTALENETTIETVNPSVRSLKSEPVGTPNIEENKADSSAEAVVEEPNEAVAESSPNEEATGQKSEDTDTHSNEQADNGFVQTEEVAENNITTESAGENNEPADDAAMEFGRPEAEIETPEVNESIEDANEPAEDSNEPVEDSNKPVKDSNKPVEDSNKPVEDSNKPVEDSNKPVEDANEPVEDTSEPVEDAGEPVQETNEFTTDIASPRHQEEDIELEAEPKDATESVAVEPSNEDVKPEEKGSEAEDDINNVSKEAASGESTTHQKTEASASLESSAVTEEQETTEAEVNTDDVLSTKEAKKNTGNSNSNKKKNKKNKKKGKKK
Protein: Oxidase (Cytochrome c) assembly 1-like (Q2M1J6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003945}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MVTWLYRFLPTSNMAAKLRSLLPPDLRLQFWLHARLQKCFLSRGCGSYCAGAKASPLPGKMAMGLMCGRRELLRLLQSGRRVHSVAGPSQWLGKPLTTRLLFPVAPCCCRPHYLFLAASGPRSLSTSAISFAEVQVQAPPVVAATPSPTAVPEVASGETADVVQTAAEQSFAELGLGSYTPVGLIQNLLEFMHVDLGLPWWGAIAACTVFARCLIFPLIVTGQREAARIHNHLPEIQKFSSRIREAKLAGDHIEYYKASSEMALYQKKHGIKLYKPLILPVTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYILPLAVTATMWAVLELGAETGVQSSDLQWMRNVIRMMPLITLPITMHFPTAVFMYWLSSNLFSLVQVSCLRIPAVRTVLKIPQRVVHDLDKLPPREGFLESFKKGWKNAEMTRQLREREQRMRNQLELAARGPLRQTFTHNPLLQPGKDNPPNIPSSSSSKPKSKYPWHDTLG
Protein: Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)] (P56974)
Organism: Mus musculus (Mouse)
Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Subcellular location: [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-2]: Secreted {ECO:0000250}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Receptor tyrosine-protein kinase erbB-3
- Epidermal growth factor receptor
- Pro-neuregulin-4, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-2
- Pro-neuregulin-3, membrane-bound isoform
- Pro-neuregulin-1, membrane-bound isoform
- Probetacellulin
- Proepiregulin
- Proheparin-binding EGF-like growth factor
Sequence:
MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVRVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGSGPGADMQRSYDSYYYPAAGPGPRRSACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL
Protein: AN1-type zinc finger protein C1271.05c (O94338)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- mRNA export factor elf1
- Elongation factor 3
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS14
Sequence:
MVLLQIIASQSYSIEVDEHSSLGNIFDLLSDQGILPKNAKSLHAFYYHGTRLNMNMTCADYGIIHDSAVHIAPLPSSCDIDFKDYSTSAFHLHFSPLTPNHASTEAVSNFKQSSTIPSISKSNLTNPPLESEKSSDKALLTRPATSRRRCCHPTCTRITLRLAGNCLHCNGRFCAAHRLMEDHDCVALFSLRKEEHERNRIKLEKEHGDTLISKV
Protein: 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Extracellular matrix protein 31) (Ketopantoate hydroxymethyltransferase) (P38122)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase required for pantothenic acid biosynthesis. Acts downstream in the pantothenic acid pathway.
Interaction partners:
- Pantoate--beta-alanine ligase
- 2-dehydropantoate 2-reductase
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Branched-chain-amino-acid aminotransferase, cytosolic
- Dihydroxy-acid dehydratase, mitochondrial
Sequence:
MNIMKRQLCTSSKRFFSTAKNVVKYNTIQDIRNKYFTGTPLSMCTAYDFITATWVNKANCDLLLVGDSLAMTSLGYDSTITLSLNEFKYHVASVCRAEGSSMVVVDMPFGTFESGISDGLKNAIDIMKLDSKVTSVKVEVGSYTKDKYAMKFIEELCSRGIPVMAHIGLTPQKVHSLGGYKVQGSKSLLQMQELYETAMQLQKIGCWSILIECVPHKMAQFITSKLSVPTIGIGAGNGTSGQVLVISDLLGMQGDSVPKFVKQAVNMTDIATQGLKEYIASVEDRTFPERGTHTFKVKEDLWNEFLSSINEK
Protein: Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed] (Q9NPJ3)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9CQR4}. Mitochondrion {ECO:0000250|UniProtKB:Q9CQR4}. Nucleus {ECO:0000250|UniProtKB:Q9CQR4}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9CQR4}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000250|UniProtKB:Q9CQR4}.
Interaction partners:
- Phosphatidylcholine transfer protein
- Dyslexia-associated protein KIAA0319
- Tyrosyl-DNA phosphodiesterase 2
- Doublecortin domain-containing protein 2
- UbiA prenyltransferase domain-containing protein 1
- Acyl-coenzyme A thioesterase 11
- Cytosolic acyl coenzyme A thioester hydrolase
- Acyl-coenzyme A thioesterase 1
- Acetyl-coenzyme A thioesterase
- Acyl-coenzyme A thioesterase 8
Sequence:
MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN
Protein: MHC class II H2-M beta 2 chain (Q31114)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIQRLQNGLQDCATHTQPFWDVLTHRTRPPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH