Protein: Dynein axonemal heavy chain 17 (Axonemal beta dynein heavy chain 17) (Ciliary dynein heavy chain 17) (Q69Z23)
Organism: Mus musculus (Mouse)
Function: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9UFH2}.
Interaction partners:
- Dynein axonemal intermediate chain 2
- Cilia- and flagella-associated protein 70
- Dynein axonemal intermediate chain 1
- Dynein axonemal intermediate chain 3
- Thioredoxin domain-containing protein 3
- Dynein axonemal intermediate chain 4
- Cytoplasmic dynein 1 intermediate chain 2
- Outer dynein arm-docking complex subunit 1
- Dynein axonemal heavy chain 8
- Dynein axonemal light chain 1
Sequence:
MPDLRIDYLETVSSVLLKFKADKWGKLIGAEENMALLTEFFDKIDNPVLVLTLNAAGMIIPCLGFPESLKSKGVYFIKMKPENITKDNYKTHLIYGDISPTTVDQLIAVVEEVLYSLLNQSENMDGWPRVVSEDIVKQVHRLKNEMFVMGGKIKGKTLLPIPEHLGSLDGTLDSMERIPSSMDNSLLHSIETIIIDWSHQIRDVLSKDSAQALLDGLHPLPRVEFEFWDARLMNLQCIHEQLNRPKVNKIVEILEKAKSCYWPALQNVYMNVTQGLKEANGIVLYLKPLRILLEEMEQADFTMLPSFIVKVLSTICFIWATSEHYNTPSRVIVILREFCNQIIEMTRTYLSPDEVLKGLQGEIEEVLGNISLSVSVLKGLFQAYDFCCANMKLFFKDRPPVPWEFPSSLAFSRMNSFFHRVQTIEDLYKTAIEFLKLEKIELGGVWGNILGNLVTQIYDEVFELVKVFAECKYDPLDPGDSSFDDDYSDFETKIQDLDRRLATIFCQAFDDCNCMESSAKLLYMCGGLLERPLILVEVVPRYSVMLEMFNTELDNAKLMYDAQMAASADGQIPPIHKNMSPVSGQLKWSLELQERLEVSMKYLKHIEHPVMSSMEAKLIYDKYDEMMGLLQSCRMKKYQQWVEGVDQDCHFNLGQPLIQRDPFTSLIQVNFSKALVAVLREVKYLNFQQQKEIPESAEKLFSENETFRKFVGNLELIVGWYNEIKTTVKDVEFPLIKSELEAIDVKLLSAETTLFWNGENVMEYIQEMREMLYNLQNRIQKAKQNVEGITQAMQEWSANPLFERKDNKKEALLDLDGRVANLNKRYAAVKEAGVRIQAMVVENAELFRADTTSQSWKDYVNYIDTVVLDEFDRFIRKSLNYLMDNMTMDESIAPLFEIRMELDKDGLTYNPSLEMGDEAGFLSLIEGLINDLYNVARLIPRLAKGRLNYKSDLEDITDLIEMREEVSSLVIGAMKVAEEYQDSFERYSYLWVDDLQEFMKNFLIFGHAPTPEELDTKTDDTIPKTPPTLAQFQQQIDSYEKLYEEVSSCENTKVFHGWLQCDCRPFKQTLLNTIKRWSFLFKRYLNNHVINSLADLESFMNITRTALKKPLKEGDYDGLVEVMGHLMKVKERQVATDSMFEPLKQTIELLKSYGEEMPEEIYLKLQELPEQWTNTKKLAIQVKQNVAPLQANEVNILRRKCQQFELKQHEFREKFRRDAPFSFSDPEPYKSLNKIYLLYGVMEALCKSASLFEVTVPDYKQLKACHREVRLLKELWDMIVMVNTSIDDWKTTKWKDINVEQMDIDCKKFAKDVRSLDKEMKPWDAFVGLDNTVKNMITSLRAVSELQNPAIRDRHWQQLMQATQVKFEMSEETTLADLLQLNLHKYEDEVRNIVDKAVKESGMEKVLKTLDITWTTMEFEHELHPRTGTMMLKSDEVLVETLEDNQVQLQNLMMSKYLSHFLKEVTSWQQKLSTADSVISIWFEVQRTWSHLESIFIGSEDIRAQLPEDSKRFDAIDQEFKALMEDAVKTPNVVEATNKPDLYNKLENLKMSLAVCEKALAEYLETKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLKFRLDASGKPLKFGLGMYSKEDEFVDFDKECDLSGQVEVWLNRVLDRMRATLRHEIPEAVVTYEEKPREQWIFDYPAQIWWTTEVGLAFARLEEGYENAIKDYNKKQISQLNALITLLIGNLTAGDRMKIMTICTIDVHARDVVAKMITVESSQAFTWQSQLRHRWDEEKKHCFANICDAQIKYSYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTKDLGRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQDAIRAKKKKFNFLGEIISLVPTVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFLDARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPTRAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEKIIKQSIVELKLQAEDSFVLKVVQLEELLQVRHSVFVIGNAGSGKSQVLKSLNKTYQNLKRKPVAVDLDPKAVTCDELFGIINPATREWKDGLFSTIMRDLANLTHEGPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAGILYINPADLGWNPVVSSWIERRKVQSEKANLIILFDKYLPTCLDKLRIGFKRITPVPEITVIQTILYLLECLLTEKNAPPDSPKELYELYFVFACFWAFGGAMFQDQLIDYRVEFSKWWINEFKTIKLPSQGTIFDYYIDPETKKFLPWTDKVPNFELDPDIPLQASLVHTTETIRIRYFIDLLMEKAWPVMLVGNAGTGKSVLMGDKLENLSTDDYLVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGTKKLIYFIDDMNMPEVDKYGTVAPHTLIRQHMDHRHWYDRQKLTLKDVHNCQYVACMNPTSGSFTIDPRLQRHFCVFAVSFPGQEALTSIYNTILAQHLSFRSAPLVIQRLSSHLVTAALALHQKVSATFLPTAIKFHYIFNLRDLSNIFQGILFSTAEILKTPLDLVRLWLHEAERVYGDKMVDEKDQETLHRVTIASVKKFFDDLGEENLFAKPNIFCHFTQGIGDPKYFPVTDVAQLNKLLKDVLDSYNEVNAVMNLVLFEDAVAHICKINRILESPRGNALLVGVGGSGKQSLSRLAAYISALDVFQITLKKGYAIPDLKMDLATQYIKSAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFGDEDLENIISSMRPQVKSLGIADTREACWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAINWFHEWPEDALVSVSARFLEETEGIEPEVKTSISLFMAYVHTTVNEMSKIYLTIERRYNYTTPKTFLEQIKLYQNLLAKKRMELVAKIERLENGLMKLQSTASQVDDLKAKLAVQETELKQKNENADKLIQVVGVETEKVSKEKAIADEEEMKVEVINKNVTEKQKACETDLAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSLKKFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRIKNKIAELNANLSNLTSAFEKATAEKIKCQQEADATNRVISLANRLVGGLASENVRWAESVENFKSQGVTLCGDVLLISAFVSYVGYFTKKYRNELMEKFWIPYINKLKVPIPITEGLDPLTLLTDDADVATWNNQGLPSDRMSTENATILCNTERWPLIVDAQLQGIKWIKNKYGSDLQAIRLGQKSYLDIIEQAISAGDTLLIENIGETVDPVLDPLLGRNTIKKGRFIKIGDKEVEYHPSFRLILHTKYFNPHYKPEMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLKANLTKSQNEFKIVLKELEDSLLARLSAASGNFLGDTALVENLETTKHTANEIEEKVQEAKITEVKINEARENYRPAAERASLLYFILNDLNKINPIYQFSLKAFNVVFEKAIQKTAPADEVKQRVINLTDEITYSVYMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELDFLLRFPFKAGVVSPVDFLQHQSWGGIKALSEMDEFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKTALQKLCMVRCMRPDRMTYAVKNFVEEKMGSKFVEGRSVEFSKSYKESSPSTPIFFILSPGVDPLKDVEALGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEKGHWVILQVRGSLPQNIHLVARWLGILDKKVERYSSGSHEDYRVFISAEPAPTAETHIIPQGILENAIKITNEPPTGMYANLHKALDLFTQDTLEMCTKEIEFKCILFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANSKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRVEMLEGEVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKVGAVPVPEGSLGSEGSLGTIGLPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDMEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLQRIRELESWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKDLTPVMPVIFIKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKTKEKAAKWILAAVALLLQV