wanglab/gogpt-training-data huggingface dataset:
Protein: RE37229p (Q8MRH0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MALSALASFDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHARRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPKDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTVSMCCAVVSRIS
Protein: Cytochrome P450, family 2, subfamily j, polypeptide 3 (Q5BKA2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Interaction partners:
Sequence:
MLATAGSLVATIWAALHLRTLLVAALTFLLLADYFKTRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQPFVKKYGNIFSLNLGDITSVVITGLPLIKETFTHIEQNILNRPLSVMQERITNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRMQEEAHYLVEAIREEKGKPFNPHFSINNAVSNIICSVTFGERFEYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIPGSHQTVFRNWEKLKLFVSSMIDDHRKDWNPEEPRDFIDAFLKEMSKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYAEVQEKVQAEIDRVIGQKRAASLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTTLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFTFKPPTNEKLSLKFRNGLTLSPVTHRICAVPRE
Protein: Uncharacterized oxidoreductase Rv0927c (EC 1.-.-.-) (P9WGQ5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- 2,4-diaminopentanoate dehydrogenase C-terminal domain-containing protein
- Uncharacterized oxidoreductase Rv0770
- Probable fatty acid synthase Fas
- Phosphate-binding protein PstS 3
- Probable short chain alcohol dehydrogenase/reductase
- Probable short-chain type dehydrogenase
Sequence:
MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL
Protein: BRCT domain-containing protein (Q583Q4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSARNKMGLEQAGSAVPSSTSGYVSTSRHSKTSESRRSGDRQVVRGMDSVRSFFSRNCKPAEVNKPSSCRRRALQTSLPVEGGNTTRGEIVAKSLDSWITKRPASASASHEVPAKVPDKRRFIRLSQSSLSSIMTDQSLVTQPLLDTPEGYDHTAGLRVESESGDLVSACTQRPVKNSHCVSPSLRCSNVGEPHLSISKQLTDDKCRIGKHNGSTKYMNNVVSSLPISIYSSPETFSCSNEATQQSNGKEGKVKAEKRPRPQMSPGQHTSMCSADQNQMAVSNDREMDERERLGTEPSNKLELPRGVLGIEGILSFEENPALARADFNVGLRVLVQREGEWLFATVVSREENGYVDVCLEGNGTTIRSTTSNLRVDEAKTGSSTERKISSGKDEKCAPLVSSPKQTNLEVIGMSEATSPNLTAPEKTQTGPCEEVSSKRVHPSVILMYVSPTVGERLGKDALHVLRNLTKSGTTLVDSPQKLQGASQRIMSAKEQYGVPQQCGKHLWGICFVLVSGTAEHYAREVRIIDEAHAVGISAVSLKWLERLHNEGSWNASSVSLPYPEELMDQNDGGVFRCSLLREAERTLRQHLVYIPIADPDIENLIELSGGKVTRTLPPNKQNCPGPSDPHWIYVKDGNQNPLRTSHPSIKTLSLERLRKRIHSYFATLPSSFSGQDDCTCFDVKADGTLVDKCLKTQDDENTASDGETAATKMGGEEHDFTLFARPCDYPTREEPKILPGEDYYFRLPRGDDREGQINQAFPVAMGRVLNVNGSSAHGRTVTMQLYRITRVYHVQDPQTGSITSRQCVCLGPETVSVMESDLIFDTGPFVFPLEAMQHLYILEQQQDCRDGASAGPPASPWNSQFSTMAPRPTQFRHRYS
Protein: Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) (P52623)
Organism: Mus musculus (Mouse)
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity).
Interaction partners:
- Uracil phosphoribosyltransferase homolog
- Uridine 5'-monophosphate synthase
- Uridine phosphorylase 1
- Cytidine deaminase
- UMP-CMP kinase
- Uridine-cytidine kinase 2
- Uridine-cytidine kinase-like 1
- Ectonucleoside triphosphate diphosphohydrolase 3
- Ectonucleoside triphosphate diphosphohydrolase 8
- UMP-CMP kinase 2, mitochondrial
Sequence:
MASAGGGGSESAAPEADRPQPRPFLIGVSGGTASGKSTVCEKIMELLGQNEVDRRQRKLVILSQDCFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHKTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYTQEIRDMFHLRLFVDTDSDVRLSRRVLRDVQRGRDLEQILTQYTAFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDLCKRHRGGPNGRNHKRTFPEPGDHPGVLATGKRSHLESSSRPH
Protein: Beta-caryophyllene synthase (EC 4.2.3.-) (Terpene synthase 6) (LdTPS6) (J7LJN5)
Organism: Phyla dulcis (Aztec sweet herb) (Lippia dulcis)
Function: Sesquiterpene synthase converting farnesyl diphosphate to beta-caryophyllene as the major product.
Interaction partners:
Sequence:
MGIHSSAENVALENVRQSVTYHPSVWGDYFLTPASNHEESSTSEGEELQESRQEVEKLLGATHDDSLQKLELIDAIQRLGVDHHFQKEIEKSLQDIYLRCCNDKDDYDHNQTDLHTVALRFRLLRQQGYNISSETFNKFTDRNGKFEESLADDVRGMLSLYEAAHCGVQGEKILDEALVFSSSNLKSILAKNHMSNSGLTARIEEAFDTPIRKCLTNFGARKFMSMYEEDESHSEALLKFARLDFNFSQKLHQKEISDLTRWWKELDFKTKLPFARDRMVECYCWTLGIHPEPQYNLARNFLSKVIMLASVIDDIYDVRGTLDELQLFTDAIQRWDISAMEQLPPYMRVCYEALLNVYAEVEELERIDGPYRVHYAKEEMKKLARAYLEESQWLYKKYIPTFKEYMSVAIPSSGYIMVAGNCLVGLGNSLVMKDFDWVSCEPLMVKASAIIARLMDDMAGHGFEKKISAVECYTNENGASEKEAFEELEKQVSNAWKDMNQEFLHPTAVSMTVLTRVLNAARVIHLLYKDGDSYTNSKTYIKELIEAVLIQPVKI
Protein: Transcription factor bHLH10 (Basic helix-loop-helix protein 10) (AtbHLH10) (bHLH 10) (Transcription factor EN 23) (bHLH transcription factor bHLH010) (Q84TK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor DYT1
- Short-chain dehydrogenase reductase ATA1
- Transcription factor bHLH90
- Protein EXORDIUM-like 6
- AP-3 complex subunit sigma
- Transcription factor bHLH70
- Transcription factor MYB80
- Transcription factor MYB35
Sequence:
MEEERESLYEEMGCFDPNTPAEVTVESSFSQAEPPPPPPQVLVAGSTSNSNCSVEVEELSEFHLSPQDCPQASSTPLQFHINPPPPPPPPCDQLHNNLIHQMASHQQQHSNWDNGYQDFVNLGPNSATTPDLLSLLHLPRCSLPPNHHPSSMLPTSFSDIMSSSSAAAVMYDPLFHLNFPMQPRDQNQLRNGSCLLGVEDQIQMDANGGMNVLYFEGANNNNGGFENEILEFNNGVTRKGRGSRKSRTSPTERERRVHFNDRFFDLKNLIPNPTKIDRASIVGEAIDYIKELLRTIEEFKMLVEKKRCGRFRSKKRARVGEGGGGEDQEEEEDTVNYKPQSEVDQSCFNKNNNNSLRCSWLKRKSKVTEVDVRIIDDEVTIKLVQKKKINCLLFTTKVLDQLQLDLHHVAGGQIGEHYSFLFNTKICEGSCVYASGIADTLMEVVEKQYMEAVPSNGY
Protein: Methyl-accepting chemotaxis protein (Q72AX1)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- histidine kinase
- Chemotaxis protein CheV
- Chemotaxis protein CheV
- Chemotaxis protein CheV
- Chemotaxis protein CheA
- Chemotaxis protein CheA
- Chemotaxis protein CheA
- Chemotaxis protein CheW
- Chemotaxis protein CheW
- protein-glutamate O-methyltransferase
Sequence:
MKFRSAGAQLAAFSSLLILVVMLAFIGIAMYSAYSGVLATETHNMAQSTRQIETSLDDFISGHALTAKGLAQQKTVASTLALGSASLVVRDQISQTIKGNAAYAAVMAFNDKGIILAGLTSTGADLTGKTLPASDILPSIMGGKDFIGREAFRDKDTGRVVITVASPILTVTGVAAGGICIALDIDTFSKRFIQPMRYGADGYPFVLDAKGIIVAHPDSSLLLSDVSQQAFVQRVLSNSEGVFDYDWKGRTKVLASVTSKVTGWKICASAYEDDIASIARKQRDILAVVGVIALGIMAAAIALMSRSMVTRPTALLCEYANAIAGGNLNARLEGTFRHELGTLADAMGRMVEDLKHRLGFAQGVLNGMVVPVLIVDREERTLFINQPCLDMLQLDGTPEQQHGRTLAEVFYNDPGRQTAVGRAMNERKAITNIDVTIKGHKGGEVQVLANVTYLADTDGNIFGGFCLYLDVTEARRQQAFIAEQNKRIGEAATQAETVSQNLSEAAATLEGQIDQAARGSDIQRQRTAEAATAMEQMNASVMEVARNAAGAAEQAETARHKAQEGASALDDSVRTIREAKQLADTLREHMGELGKQAEDIGRVLDVIADIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAEKTMNATREVDTAIKGIQTSARSNIDNTRKATDAIEVGTGMVGKSGEILREIVRLVETTADSVRNIATASEEQSAASEQITRSTDEINRIASETADAMQQSARAVQDVASLADELHGVIEEMRRQ
Protein: Frizzled-5 (Fz-5) (Q8CHL0)
Organism: Rattus norvegicus (Rat)
Function: Receptor for Wnt proteins. Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20530549}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQD0}. Synapse {ECO:0000269|PubMed:20530549}. Perikaryon {ECO:0000269|PubMed:20530549}. Cell projection, dendrite {ECO:0000269|PubMed:20530549}. Cell projection, axon {ECO:0000269|PubMed:20530549}. Note=Localized at the plasma membrane and also found at the Golgi apparatus. {ECO:0000250|UniProtKB:Q9EQD0}.
Interaction partners:
- Protein Wnt-5a
- Protein Wnt
- Protein Wnt
- Low-density lipoprotein receptor-related protein
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- LDL receptor related protein 5
- Receptor-like tyrosine kinase.
Sequence:
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGVCYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMVAGDYAEASAALTGRTGPPGPAAAYHKQVSLSHV
Protein: Ras homolog family member A (G1MTS2)
Organism: Meleagris gallopavo (Wild turkey)
Interaction partners:
Sequence:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLLL
Protein: NADPH--cytochrome p450 reductase, putative (EC 1.6.2.4) (Q583J8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Anamorsin homolog
- Homocysteine S-methyltransferase, putative
Sequence:
MEENEGIGTITILYGTQTGSAEQLAFTFASLAIKRGFKRCVCLPADEFPLDKWRDATPLVIICSNANQGEAPDSIRISWAQLLHSTAPSMDGLRFAVFGTGDSIYPKFNYMAKMLHNRLRQLGGTPLLNRGLGDESDRKGYDEVFLPWVLELWRALGLVSEDDSHLKEENPSDAPLLCKYEVVPCNDESAPQGGVDVAVRRREPVFNCRLVQNKRLTAEDHLQAVHHIAFSRETTPAEGSLLPYDTPLAFEVGDALGVYCTNEDAIIDRVLTQVNEDGDKVVCIKPNNSQGIIQQQEQPFFNRPMTLRFFLKHYVDLEAVVSRSFFRMMAHYAEDAELKERLWELSSSDNLDDFMWYCQREKRNVAEVLDDFRAVRPPLALLLSFMPPMRARLFSISSSPYVDCDTFHLTVALVEWQTPYKRTRRGLCSSRLTSAKPGDVFTCFLWDGTMITPSTPAPLLCVGTGTGVAPIRSLIRECAGHSDIWGEVPILLFFGCRNETKDYLYQQEWADLKRDHLKQLQVLPAFSRDGEKKFYVQHQIGRHARRVAKLLDAGATIYVCGNSKQMPKDVATTLEDVVTQCCCEGDEAKSQEYMKQLRKQGRYVVDTWSV
Protein: C-reactive protein (P48199)
Organism: Rattus norvegicus (Rat)
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Insulin-2
- Interleukin-6
- Insulin-1
- Tumor necrosis factor
- Apolipoprotein A-I
- Albumin
- 30 kDa adipocyte complement-related protein
Sequence:
MEKLLWCLLITISFSQAFGHEDMSKQAFVFPGVSATAYVSLEAESKKPLEAFTVCLYAHADVSRSFSIFSYATKTSFNEILLFWTRGQGFSIAVGGPEILFSASEIPEVPTHICATWESATGIVELWLDGKPRVRKSLQKGYIVGTNASIILGQEQDSYGGGFDANQSLVGDIGDVNMWDFVLSPEQINAVYVGRVFSPNVLNWRALKYETHGDVFIKPQLWPLTDCCES
Protein: Histone H3.3 (H3.2) (Q0JCT1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Os02g0784100 protein
- Os02g0782800 protein
- Histone H4
- Histone H4
- Probable lysine-specific demethylase SE14
- Os01g0884500 protein.
- Os06g0255200 protein
- Os03g0207900 protein
- ARID transcription factor
- Os09g0544500 protein
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPTTGGVKKPHRYRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSHAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Protein MCM10 homolog (Q5T670)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKVCHLRTNF
Protein: Transcription factor WER (Myb-related protein 66) (AtMYB66) (Protein WEREWOLF) (Q9SEI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:16207757}.
Interaction partners:
- Transcription factor EGL1
- Transcription factor GLABRA 3
- Protein TRANSPARENT TESTA GLABRA 1
- Transcription factor MYC1
- Homeobox-leucine zipper protein GLABRA 2
- Transcription factor RHD6
- Protein TORMOZ EMBRYO DEFECTIVE
- Zinc finger protein JACKDAW
- Transcription factor RSL3
- Transcription factor RSL2
Sequence:
MRKKVSSSGDEGNNEYKKGLWTVEEDKILMDYVKAHGKGHWNRIAKKTGLKRCGKSCRLRWMNYLSPNVKRGNFTEQEEDLIIRLHKLLGNRWSLIAKRVPGRTDNQVKNYWNTHLSKKLGIKDQKTKQSNGDIVYQINLPNPTETSEETKISNIVDNNNILGDEIQEDHQGSNYLSSLWVHEDEFELSTLTNMMDFIDGHCF
Protein: Dual specificity protein phosphatase TpbA (DUSP) (EC 3.1.3.16) (EC 3.1.3.48) (Dual specific tyrosine phosphatase) (Tyrosine phosphatase related to biofilm formation A) (Q9HXC7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Periplasm {ECO:0000250|UniProtKB:A0A0H2ZFK2}.
Interaction partners:
- NADH-quinone oxidoreductase subunit C/D
- Diguanylate cyclase TpbB
- NADH-quinone oxidoreductase subunit M
- Negative regulator YfiR
- Acylphosphatase
- TIGR01459 family HAD-type hydrolase
- NADH-quinone oxidoreductase subunit B
- NADH-quinone oxidoreductase subunit H
Sequence:
MHRSPLAWLRLLLAAVLGAFLLGGPLHAAETAATRSPAWAQAVDPSINLYRMSPTLYRSALPNAQSVALLQRLQVKTVVSFIKDDDRAWLGQAPVRVLSLPTHADRVDDAEVLSVLRQLQAAEREGPVLMHCKHGNNRTGLFAAMYRIVVQGWDKQAALEEMQHGGFGDEDDMRDASAYVRGADVDGLRLAMANGECSPSRFAVCHVREWMAQALDRP
Protein: Tau-theraphotoxin-Hs1a (Tau-TRTX-Hs1a) (Double-knot toxin) (DkTx) (P0CH43)
Organism: Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Function: Selectively activates the heat-activated TRPV1 channel. It binds to TRPV1 in an open state-dependent manner, trapping it there to produce irreversible currents. It binds to the outer edge of the external pore of TRPV1 in a counterclockwise configuration, using a limited protein-protein interface and inserting hydrophobic residues into the bilayer. It also partitions naturally into membranes, with the two lobes exhibiting opposing energetics for membrane partitioning (K1) and channel activation (K2). In addition, the toxin disrupts a cluster of hydrophobic residues behind the selectivity filter that are critical for channel activation.
Subcellular location: Secreted {ECO:0000269|PubMed:20510930}.
Interaction partners:
Sequence:
DCAKEGEVCSWGKKCCDLDNFYCPMEFIPHCKKYKPYVPVTTNCAKEGEVCGWGSKCCHGLDCPLAFIPYCEKYRGRND
Protein: Protein sprouty homolog 2 (Q7Z783)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARASLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRTLKNQHSIINQEYYSNEDFFCLFLIHICNQLNSYNLGTVNRKLG
Protein: Arginine kinase Lit v 2.0101 (EC 2.7.3.3) (Allergen Lit v 2) (Arginine kinase) (AK) (LvAK) (allergen Lit v 2.0101) (Q004B5)
Organism: Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei)
Function: Catalyzes the reversible transfer of high energy ATP gamma-phosphate group to L-arginine. Has nucleoside diphosphate kinase-like activity toward dTDP. Binds and phosphorylates dTDP using ATP as a phosphate donor. Does not phosphorylate dADP, dCDP, dGDP, dTMP or thymidine.
Interaction partners:
Sequence:
MADAAVIEKLEAGFKKLEAATDCKSLLKKYLTKEVFDKLKDKRTSLGATLLDVIQSGVENLDSGVGIYAPDAEAYTLFAPLFDPIIEDYHVGFKQTDKHPNKDFGDVNSFVNVDPEGKFVISTRVRCGRSLQGYPFNPCLTESQYKEMEAKVSSTLSSLEGELKGTYYPLTGMSKEVQQKLIDDHFLFKEGDRFLQAANACRYWPAGRGIYHNDNKTFLVWVNEEDHLRIISMQMGGDLGQVFRRLTSAVNEIEKRIPFSHHDRLGFLTFCPTNLGTTVRASVHIKLPKLAANREKLEEVAGKYNLQVRGTRGEHTEAEGGIYDISNKRRMGLTEFQAVKEMQDGILELIKIEKEM
Protein: Actin (EC 3.6.4.-) (P10989)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tropomyosin
- Profilin
- Fimbrin
- Cofilin
- Alpha-actinin-like protein 1
- Probable actin-related protein 8
- Helicase swr1
- Chromatin-remodeling ATPase INO80
- Cell division control protein 42 homolog
- Cell division control protein 12
Sequence:
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPCLLTEAPLNPKSNREKMTQIIFETFNAPAFYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAIMRLDLAGRDLTDYLMKILMERGYTFSTTAEREIVRDIKEKLCYVALDFEQELQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSALGLENAGIHEATYNSIMKCDVDIRKDLYGNVVMSGGTTMYPGIADRMQKEIQALAPSSMKVKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVYRKCF
Protein: Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) (Q8BMA3)
Organism: Mus musculus (Mouse)
Function: Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22851176}. Apical cell membrane {ECO:0000269|PubMed:22851176}; Peripheral membrane protein {ECO:0000269|PubMed:22851176}.
Interaction partners:
- Interactor protein for cytohesin exchange factors 1
- Coiled-coil domain-containing protein 175
Sequence:
MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDTMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENVSFGYRGHSKSKQPLPVRKGSESPNSFLDQESQRRRFTIADSDQLPGYSVETNVLPTKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKPRGNGRKGEDALCRYFSNERITPITEESASPMYRFSRPLTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGSKKKSASSSAKASSGEPSLLVSWLTRLKLLTH
Protein: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) (P62138)
Organism: Rattus norvegicus (Rat)
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62136}. Nucleus {ECO:0000250|UniProtKB:P62136}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P62136}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62136}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting it to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000250|UniProtKB:P62136}.
Interaction partners:
- Protein phosphatase 1 regulatory subunit 3B
- Protein phosphatase 1 regulatory subunit 7
- Protein phosphatase 1 regulatory subunit 3A
- Protein phosphatase 1 regulatory subunit 3C
- Retinoblastoma-associated protein
- Serine/threonine-protein phosphatase 1 regulatory subunit 10
- Tumor protein p53 binding protein, 2
- Protein phosphatase 1 regulatory subunit 15A
- Leucine-rich repeat protein SHOC-2
- WD repeat-containing protein 82
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK