wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome c oxidase subunit 8B, mitochondrial (Cytochrome c oxidase polypeptide VIII-heart) (Cytochrome c oxidase subunit 8-1) (Cytochrome c oxidase subunit 8H) (P16221)
Organism: Rattus norvegicus (Rat)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10175}.
Interaction partners:
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 7B, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 8C, mitochondrial
- Cytochrome c oxidase subunit 6A2, mitochondrial
- Cytochrome c oxidase subunit 7A1, mitochondrial
- Ubiquinol-cytochrome c reductase, complex III subunit X.
Sequence:
MPRLPPILRLLQAPEKYTVIPKARISSKPAKSPTSAMDQAVGMSVIIAGFMVPAGWVLSHLESYKRSSAA
Protein: Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05 (O13686)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in telomere capping.
Interaction partners:
- Uncharacterized WD repeat-containing protein C12G12.01c
- Nitrogen permease regulator 3-like protein
- Uncharacterized WD repeat-containing protein C4F8.11
- Protein transport protein sec13
- Vacuolar membrane-associated protein iml1
- Nucleoporin seh1
- Nitrogen permease regulator 2 homolog
- GTP-binding protein gtr1
- Mitochondrial inner membrane protease subunit 1
- Vacuolar morphogenesis protein 6
Sequence:
MRELQGDDSSRKSPPSDSVVKNSSPIDYEHSLKSLQDERTLNYPNKQFNSENPSSYYNMDDSGELCNFELEKDSLESMIHESSTALSAQSNTAQDGDQLASSSTISKDHSETLDNKLNDSKILIKKASNSFANFSESVRSSTIVAYSQTPTQRLQGLTSISSSSFDDGSYGSRRISFNSQGVSGRLRRNMDSTVIIPSEDEDLQLPSNSNSNVEYGPFDSTTFDRQLSIEVNQPVGAMSLSPCGRDIALASRYGLLVLDLDNPYNPPRMLRHSTPWEVADTQWNVHAARDQWVVSTSSQKTIVWNLALPNDRAIEFMLHGHTRAVTDMNWHRQNPDVLATCSIDSSVHCWDLRSPRFPVNSFYDWHNGATQVKWNYKNPHILASSHGRLVRIWDDRYGSAPLHTIKTSENITKINGLEFNRACETRLLTCAMDRTVKFWNYEKSTEEPEHLITTDSPVWKARFTPFGDGVILMPQRGDNSVHMYDCRNLDKEGPRAVHRFAGHTDQVKEFLWRCRGEDVFDRDLRDFQLITWSKDHHVRLWPIGNDILNSMGHDRTKPVPFKLTRLGAKYRTYSREPLKQSLINTECDSSDAMNSFDSNFGAERANTSDLSRGFVAFANRKKSKYNLPGSSGFMTRSTKSTNPMTPLNWLRGISMGRLGNADWEVPQNLGEELSWIGQKYSNVSFEKIDVAERTCTISLNAPILPDDGYAYIRLHVYFPNNYPISATPVFQLERSSAFNDEQFNYVFNTLTSISDQCISSHKYCMDACLSYLSGNLSVDEIWKLGFQKDNSDSSSESSADIFQDVFPSMPDFRGGDRGLSHKHQNIPLPKTCAAIFCGNDELVCFFTIKADESAAQATANRETHGRQKLFESFGVLDSSNSVADSDSTNYDDENSLNRGGTSESDSEFIWDVDESNSGSIVFPKSKTSINLNNINSASASIMGSRFGAADIFMSKRPSTKGSNRPSILLSKPSHDFHVVRIISMSKYLPVKRALAAEYVVDTGDKVTVCNKNAEVSAKHNYYRLAKVWLMLGRLLGHLSRTENKDHINDEEAFPWLKSPLAKWVVNSLLDYYASQCNTQMLAMLACVLDIPNPKKQSGNTSADQVLFNQPKQVTEKLGVQLNLPKTKILEKVSSHSLAQITALREKEPKDADSTYSKEKIFSATSTVHLQLMDYDKQNNDFVDAQEIAYTKLLQQKFIQWRATYAEQLDLWGFFIPKLEMLKFNAHEFSSPSEKTLVNHCNSCNSTTSNTRICEKCYSLVPRMSCTFCCLSIHGLCIVCGLCLHVMHEDCYKEWFSNGDSISQSCSSGCGCKCQFQHMSLEKV
Protein: Snake venom metalloproteinase kistomin (SVMP) (EC 3.4.24.-) (P0CB14)
Organism: Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma)
Function: Snake venom zinc metalloprotease that inhibits platelet aggregation by binding specifically to platelet glycoprotein VI (GP6) and platelet glycoprotein Ib alpha (GP1BA). It inhibits the interaction between collagen and platelet GP6 by cleaving GP6 (at '225-Glu-|-Ala-226' and '238-Val-|-Phe-239' bonds), and inhibits vWF-induced platelet aggregation by cleaving GP1BA and vWF. Cleavage of GP1BA occurs at two distinct sites to generate two soluble fragments. It also cleaves alpha- (FGA) and subsequently the gamma-chain (FGG) of fibrinogen, leaving the beta-chain unaffected. It also inhibits collagen-, convulxin- and ristocetin-induced platelet aggregation. It blocks the adhesion of platelet to immobilized collagen, but only exerts a slight inhibition to fibrinogen. In vivo, it exerts potent antithrombotic effect.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MIEVLLVTICLAAFPYQGSSIILESGNVNDYEVVYPRKITALSEGAAQQKYEDTMQYEFKVNGEPVVLHLEKNKELFAKDYSETHYSPDGTRITTYPSVEDHCYYQGRIHNDADSTASISTCNGLKGHFKFHGERYFIEPLKLPGSEAHAVYKYENIEKEDETPKMCGVIQKWKSDELIKKPFRLNLTPQQQESPQAKVYLVIVADKSMVDKHNGNIKKIEEQGHQMVNTMNECYRPMGIIIIMAGIECWTTNDFFEVKSSAKETLYSFAKWRVEDLSKRKPHNDAQFLTNKDFDGNTVGLAFVGGICNEKYCAGVVQDHTKVPLLMAITMGHEIGHNLGMEHDEANCKCKACVMAPEVNNNPTKKFSDCSRNYYQKFLKDRKPECLFKKPLRTDTVSTPVSGNEPLEVITMDDFYA
Protein: NPC intracellular cholesterol transporter 1 homolog 2 (Niemann-Pick C1 protein homolog 2) (P34389)
Organism: Caenorhabditis elegans
Function: Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative protein heh-1
- Sterol regulatory element binding protein sbp-1
- 3-ketosteroid oxygenase
- Cholesterol 7-desaturase
- 3beta-hydroxysteroid dehydrogenase dhs-16
Sequence:
MRQGGGGGERMVSVLFLLLIHLALCQAKCVMTECDGEEDSNHPPCKTNKSTYLPITVTRSLNPTYMARFEKYCSYLVQEEDKAQVCCTELQLKGMTDRISNAATILGSCPSCFDNFAKLWCQFTCSPDQSKFMKVMETTGPKNVVVKMEFKVNRDFVEGLYESCRHTWFANGLALRLMSLGGKVSFENFYGFMGTKNLAQSIPINTEFQFSRMKNAMNIPTTPCHKSAGPKVPACGAIDCPTNAHQLVDISKVEHLGTKVFHPHFPDFEWLLKICGCLALTVLLVFILKYSCHRRSAPNGEDGCYVDLGKGNLEVQFEGLCARYANAVIKHPLIFVSLGLIVAAACCSGNFKFHSLTHSVDQVSAADGETRRNEKKFIHSFGPNHRIEQIFINLPPTTKSMFNMPLFEEMFQLVGNIQNLTACYGNSSVKLDDICYKPIGKNHGCAIMSPTNYFQNKWTNFENAGPPTIDDEIFDDQHWEHLKYCIRNPLTVSTYSEMSCFGEFSGPIDPILVFGGSNESIKGAEMYYTARTIMITVLIRGPEDQAIAWETAFLNMMSRYEMKHANFTFMTETSVAEEIHTAVETDKIVSVIACAAVLIWVITMLGINHWPESSILSALVHHKLLISISAVMISVISVWCSIGMFSLFGVHATDNAIVVLFFVITCLGINRIFVIIRTFQANGHCYGLPNISYREMNHRISNVMRRSIPIVLTNSLICSTCLFLAGGVLPYVSVSMPAVEVFARHAGLAILMDTAFYLLVMLPLFQYDARREMSGKCEIWPWYELSNESKINLCMEAVDGNLRSPVDWFKLAIAPLLLKKICRIWIATFFFVSLIIACYCTLCLEFGFNQVMAFSETSYLTKHFQNMNENLNIGPPLWFVVEGDVKWHDPKMQNKFCTLAGCDDNSMGNKIRSLAYAENYKGNYLHGDVNIWLDSYLQFMHPRGSCCKMDGKQFCDPSNATHCSSCSSSSVASLTTTEYEFYRNLHHFLETPPSIQCAHGGMALAKPAINLTRNGKIQSAYFSTFFKKLNLSDSIQLYDAWRFAKYLADDIERELEIPGVKVYVYSTFFPYYEQYLTLSTTVYTLVVLVLFVAFVTISLFLRVNLAGSLVTVFVLLSSYLHLMEWMYLLGITVNVVSVINMAMSLGIAVEFFGQMLHGFYNSKKPKREERAFAALVSNGSTTLSGIFPAIMITAGCLSFADSRVLITYFCNQLVGIGLVCAVHGVVYMPTLLAIFGSDFYQNVSSEEESTDEAELQDTPPSTTSSTSSTSETSV
Protein: Large ribosomal subunit protein eL39 (60S ribosomal protein L39) (P62892)
Organism: Mus musculus (Mouse)
Function: RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL19
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein eS21
- Ubiquitin-like protein FUBI
Sequence:
MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL
Protein: Sesquiterpene synthase 12 (SlTPS12) (Terpene synthase 12) ((E)-beta-ocimene synthase TPS12) (EC 4.2.3.106) ((Z)-gamma-bisabolene synthase TPS12) (EC 4.2.3.-) (Alpha-humulene synthase TPS12) (EC 4.2.3.104) (Beta bisabolene synthase TPS12) (EC 4.2.3.-) (Beta caryophyllene synthase TPS12) (EC 4.2.3.57) (Beta-myrcene synthase TPS12) (EC 4.2.3.15) (Gamma-curcumene synthase TPS12) (EC 4.2.3.-) (Limonene synthase TPS12) (EC 4.2.3.-) (Terpinolene synthase TPS12) (EC 4.2.3.113) (D5KXD2)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (1E,4E,8E)-alpha-humulene and (-)-(E)-beta-caryophyllene, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into beta-bisabolene, gamma-curcumene and (Z)-gamma-bisabolene. Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, (E)-beta-ocimene, limonene and terpinolene.
Interaction partners:
Sequence:
MASSSANKCRPLANFHPTVWGYHFLSYTHEITNQEKVEVDEYKETIRKMLVEAPEGSEQKLVLIDAMQRLGVAYHFDNEIETSIQNIFDASSKQNDNDNNLYVVSLRFRLVRQQGHYMSSDVFKQFINQDGKFKETLTNDVQGLLSLYEASHLRVRDEEILEEALTFTTTHLESTVSNLSNNNSLKAEVTEAFSQPIRMTLPRVGARKYISIYENNDAHNHLLLKFAKLDFNMLQKLHQRELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVIQMASFFDDTFDAYATFDELEPFNNAIQRWDINAIDSVPPYLRHAYQALLDIYSEMEQALAKEFKSDRVYYAKYEMKKLVRAYFKEAQWLNNDNHIPKYEEHMENAMVSAGYMMGATTCLVGVEEFISKETFEWMINEPLIVRASSLIARAMDDIVGHEVEQQREHGASLIECYMKDYGVSKQEAYVKFQKEVTNGWMDINREFFCPDVEVPKFVLERVLNFTRVINTLYKEKDEYTNSKGKFKNMIISLLVESVEI
Protein: Probable serine/threonine-protein kinase mps1 (EC 2.7.11.1) (Monopolar spindle protein 1) (Q54UL8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD2A
- Kinetochore protein Ndc80
- Probable inactive serine/threonine-protein kinase bub1
- Kinetochore protein Nuf2 N-terminal domain-containing protein
- Kinesin-related protein 13
- separase
- dCTP deaminase
- Probable ubiquitin-conjugating enzyme E2 C
- Kinetochore protein SPC25
- Aurora kinase
Sequence:
MDTHQSFNENQHPNFNSGNHGGINMNRFQRFSKPTISPIQQQQQPQPQQPSSIIQRQSIIMTQPQPQPQPQMIPIFREPNEWYKLIDMEMNKFNNESRPSPEYIKYLTQLFQQALDSLEHKNTPEFYLFLLNRATFQSKIGENEDAKGTLKYMKVLKMESFEVFVLLSEIESKSFRFSKARSIINRGIQKIPSRSKEFEGFLMVIDIQEDEFSRNGCIISNNNNISFNNGDVNNNSIIMNENDQPMVINLNPQQQQQQQQQPYEISSSSSLMSTPASSRHLSNRSSIVPTPNSSTKLSESIKTIGLRSVQPRRVIHKQTTTNFNTTTTTIPENSYDDDADQPMDHDGNNNNNFRIHSNNNNNSSANSSYNKSENDEDDQDEEDEEEEDEDEDDDEEDEEEYEDNNNNNNNNNNNNNNNNNNNNNNNNNNYFKYNRQQYILNNDSDTSTNPNSPASSNSSVNDIINSISITDDSKLDYENNVKLQQQQQQQQQQQQQQQQQQQQQQQQQYIQQQQQQQPKIHPQRFSLQNNTPTTTTTTTAATNVQNPSSSSSYISPPLSSQSSELQHQRRHSIQAQRANKPPVIPPPSKLHQNNLQQQQQQQQQQQQQQQQQQQQQLLLQQQALLQQQQQQQILLQQQQQQQQQQQQQQQQQKQQEQQLKKTNMQPPPPKQPQPQTQTQQQQKNINNSEIVDKEKSFEVAKSWSEVAMVNGKPYLRIEFIGKGGSGKVYKVLSGDLKIYALKYVCLSDPNEIEAQLNEIEMLKRLRKQVNIIQLIDYEVNMAKNYILLVLEFGEIDLSKLLQRLQTPNGTNVNFIRIYWQQMLQAVHTIHEEKIIHGDLKPANFVSVQGSLKLIDFGIAKAIQSDDTTNIVRESQIGTINYISPEALIDTSQGGPKQCMKLGRASDIWSLGCILYEMAFGYPPFKSFSNIISKYQAIINPHHKIEFPVHPNENLLKVLKLCLIRNPHERPTIPTLLNHDFLKI
Protein: Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) (O95236)
Organism: Homo sapiens (Human)
Function: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH
Protein: Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Altered inheritance rate of mitochondria protein 10) (Prolyl-tRNA synthetase) (ProRS) (P39965)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Isoleucine--tRNA ligase, mitochondrial
- Isoleucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, mitochondrial
- Leucine--tRNA ligase, mitochondrial
- Glutamine--tRNA ligase
- Leucine--tRNA ligase, cytoplasmic
- Glutamate--tRNA ligase, mitochondrial
- Glutamate--tRNA ligase, cytoplasmic
- Valine--tRNA ligase, mitochondrial
Sequence:
MLKYRTLSRSCHIFHPKSLSNNTLKSETTQELLQTVGFVRRSQVGLFQWLPLGLRSLNKVSNAIRNRMDSDGGAIEVSLSAISSKALWQATDRWNNSELFKLKDSKGKQYCLTATCEEDITDLMKNYIASYKDMPITIYQMTRKYRDEIRPRGGILRGREFLMKDAYSFASNEEDAFASFQKLDDTYNKIFKDLKIPFVSAWADSGDIGGEFSKEFHLIHESGEDTLMSCKHCGDISTLDMSQSYPEKDGQYSGDVDCKYALTKDHSTLICFYYPKDRQLNWNLALNAMDKDIDLTLRNKPNDHVLQVYEKDNEDIMFSKILRVMDCRLNSKSNFPDFPLKKYLKNNFGQISDVSIVDAQENEICGKCEEGRLEPLKSIEVGHIFLLGNKYSKPLNVKFVDKENKNETFVHMGCYGIGVSRLVGAIAELGRDSNGFRWPAIMAPYKVSICTGPNNPENSQRLQDVKSELLNDPTMQNLQNDILDQFNEKLGIGARIKLSHAMGIPLCVIVGSKSWPNVEIEVRGIRWGEKDLWRKQFEKRCSELQWKCTKNEHGIEKHTVPIQHLAEVIGVLLKDM
Protein: Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) (P06730)
Organism: Homo sapiens (Human)
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity).
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:25923732}. Cytoplasm {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:1384058, ECO:0000269|PubMed:15657436, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:36843541}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093}. Nucleus {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:11423616, ECO:0000269|PubMed:1384058, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:36843541}. Nucleus speckle {ECO:0000269|PubMed:10648556}. Nucleus, nuclear body {ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:15657436}. Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257). Sequestered in the nucleus by EIF4EBP1 and EIF4EBP2 (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:25923732}.
Interaction partners:
- Polyadenylate-binding protein 1
- Eukaryotic initiation factor 4A-I
- Eukaryotic translation initiation factor 4E-binding protein 1
- Eukaryotic initiation factor 4A-II
- Eukaryotic translation initiation factor 4E-binding protein 2
- Eukaryotic translation initiation factor 4 gamma 2
- Eukaryotic translation initiation factor 4B
- Eukaryotic translation initiation factor 4E-binding protein 3
- Eukaryotic translation initiation factor 4 gamma 1
- Eukaryotic translation initiation factor 4E transporter
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Protein: MAU2 chromatid cohesion factor homolog (Cohesin loading complex subunit SCC4 homolog) (Mau2 sister chromatid cohesion factor) (Q9VFC0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to chromatin from the end of mitosis until prophase. {ECO:0000250}.
Interaction partners:
- Nipped-B protein
- Structural maintenance of chromosomes protein
- Protein wings apart-like
- Precocious dissociation of sisters 5, isoform A
- FI11703p
- LD34181p
- separase
- Protein dachsous
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein 5
Sequence:
MSASTSTSTAASQDACYISLLGLAEYFRTSQPPNIKKCIQCLQALFTFMPPSKVEARTHLQMGQILMAYTKNIDLARQHLEKAWSISEPLPNFDVKFDTASLLAQLHLQTDRNSHQAKAMLRRAVELSQNNVYWHCKLLLQLAQIHASDREYSLASELLAVGAESADEASATYLKVLFLLSRAMILMIERKTNDVLALLNSAGQIIDNNIPNPHQKEYLKVFFLVLQVCYYLALGQVKTVKPSLKQLQMSIQTIMAPNWPSDEAIFGANQLEMFVWLPKEQLYVLVYLVTVSHSMMAGYMDKAQKYTEKALTQIEKLKQQEDKPILSVFKVILLEHIVMCRMVMGNRELAIREIAAARDVCMAAPQRSLLRRHSAQLHCLIGLYSMSTNLFEHAERQFVVCVSETSERDLKLFANLNLAIIYLRTKRDTDLKQILDAVSTENTHTYSSQALMGGFYYVQGLHAFHKNSFHEAKRFLRETLKMANAEDLNRLTSCSLVLLSHVFLSIGNSKESMNMVTPAMQLASKIPDIHVQLWGSAILKDLHRMSKDVQHEKDAYANHVKYSENLIADQRKCVQSAHHELVNWFQGDPPVTSGPPAAPVLLMPESSVTASVPVIASTSTAMQPAGQYGQFY
Protein: Noggin (cNoggin) (O93525)
Organism: Gallus gallus (Chicken)
Function: Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis.
Subcellular location: Secreted.
Interaction partners:
- Bone morphogenetic protein 7.
- Bone morphogenetic protein 4
- Noggin
- Bone morphogenetic protein 6.
- Uncharacterized protein.
- Growth/differentiation factor 5
- BMP5
- Bone morphogenetic protein 2
- Growth differentiation factor 7.
Sequence:
MDHSQCLVTIYAAAVLLGLRLQQGSCQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLMGGHFDPNFMAMSLPEDRLGVDDLAELDLLLRQRPSGAMPGEIKGLEFYDGLQPGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGSRFWPRYVKVGSCYSKRSCSVPEGMVCKPAKSVHLTILRWRCQRRGGQRCTWIPIQYPIIAECKCSC
Protein: Uncharacterized protein C1198.03c (Q9P6I6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Note=Localizes at the cell tip and the barrier septum.
Interaction partners:
- Uncharacterized alpha-1,2-galactosyltransferase C1289.13c
- Mitochondrial import inner membrane translocase subunit tim8
Sequence:
MDIKDEKALTIEKACTINVFAPFVRNVTAEDEKAVTNKKHINSSATVHVFHGVVNRTFKTKGNTVGLPKSFSKAVIETLSYKPFAPICIHSRSDEVVNGFPLIYFPEDLASHDISGKDWKSFIHDVNMACSFSDVALMGLDQILNLVSFGLSAYVISYYVEKYVDKAKFPIIKGFIEMWNRKFFNPRKTHVYFINSDEVAEQRAVSIKAYQQGKGTKGLFSKFNAQREWKKQHQDISSTQHSRLLLISL
Protein: (thale cress) hypothetical protein (GB1) (A0A178UPG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MFSLMSGLWSYMFSKTEFNVLILGIDKAGKTTFLEKLKTIYSISEGLPHDRIVPTVGLNIGRIEVSNAKIVFWDLGGQPGLRSIWEKYYEEAHALIYLIDAACPTRFEDSKSALEKALRHEDLQGAPLLILANKQDLTNAVSAEELDRYLDLKKLDERVYMFEAVSGYDGRGIKESIEWLVGVMEKSKRTESLRARAGYTPVPNS
Protein: General transcription and DNA repair factor IIH subunit TFB5 (TFIIH subunit TFB5) (RNA polymerase II transcription factor B subunit 5) (Q3E7C1)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit TFB4
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIE subunit beta
- General transcription and DNA repair factor IIH subunit TFB2
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- General transcription and DNA repair factor IIH subunit SSL1
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH subunit TFB1
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- Cyclin CCL1
Sequence:
MARARKGALVQCDPSIKALILQIDAKMSDIVLEELDDTHLLVNPSKVEFVKHELNRLLSKNIYNPMDEEENQ
Protein: Translin (O28024)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Interaction partners:
- Riboflavin kinase
- FAD synthase
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
- tRNA
Sequence:
MRLEECRKRLEELEAAREELLKVLREMRIHSTKSIALIHAGKVEEAEQELKKAIELLEKVKAYREYPEIYFYLCNDAMQELVEAIAFKNAISGEFTFEIDLEVTPAAFLNGFADAVGELRRYALTKLIEGDFKSAERMLEVMEKIYERLMEFTTFPDKLVSGLRKKLDVARGGIERTKSDYIAAKVARLNESLGGN
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (E7F3D4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000929}.
Interaction partners:
Sequence:
MVRWFHRDLSGLDAEAVLKSRGVHGSFLARPSKKNVGDFSLSVRVGEIITHIRIQNTGDYYDLYGGEKFATLAELVEYYTGDHGTLQDKDGTVIELKYPLNCSDPTTERWYHGHLSGPNAEKLLRERNEPGTFLVRESLSKPGDFVLSALTDDQTSSGRRVSHIKIMCNNDRYTVGGKDQFDNLTDLVEHFKRVGIEELSGTMVYLKQPYYSTRLNAADIQSRVNQLDQTSEREKMDGADKKIKAGFWEEFDALQKLETKVTKSRDEGMRPENKSKNRYKNILPFDETRVILENADPNVVGSDYINANYVINKLMVTNPQKTYIACQGCLATTVDDFWQMMWQEDSRVIVMTTREVEKGRNKCVPYWPTTEGESKEVGRYVVKLLSEMDAADYKVRVVELSAPHRNEAPRKIWHFQYLSWPDHGVPQEPGGVLSFLDQVNRKQEELRSSAPIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYKFIYLAVLQYIESTKVTRRAIMETETEYGNLSIQSKHPKASRKASSKKNEDVYENLGAKGKKDVKKQKSEEKKGGGSVRKR
Protein: Sex-determination protein fem-3 (Cr-FEM-3) (Q8I8W7)
Organism: Caenorhabditis remanei (Caenorhabditis vulgaris)
Function: Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite) animals, it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. Together with fem-2 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1 (By similarity).
Interaction partners:
Sequence:
MTCDDFRAEDEQPIEVDERRRRLKRKANDDDDDDETVRERVDDAESSMEVFEAEYPPILDPLQDQREAKYFRERMQRFDLYSRTTGLSVDDIDWPLIRGRSLQKGRVAGISFVYDDTRYPINRFSDTWLLCVTKQKLFSFGAGCVEDLNITSFVLRRTMKVLSTYCNWLFEAAKRNNRRHITHKEIQELINRDGFRFHQYLQKFLIGRGMEYTEYNNRFFKYLHEEYNKNPGGLETIYSNQDFIAKETAQANYIYDTVRAKYGGFEELPLFRHALKISFTQPGEHYFSRFYAKRFHEALGCPPLDSEIIMILDWFGVLIMNQIAYKTIRWHEEEYNDGSFPVLDSYHKALADESKCPKACLISISLFPDDPLFDLDIDYGTNPPPVNTAYQKVRRTPRDPTPFYRLMEFEDYKSCLVKMHFNFSELTGEWLRKICARGR