wanglab/gogpt-training-data huggingface dataset:
Protein: Transcriptional repressor protein YY1 (Delta transcription factor) (NF-E1) (UCR-motif DNA-binding protein) (Yin and yang 1) (YY-1) (Q00899)
Organism: Mus musculus (Mouse)
Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'-CGCCATTTT-3') of Moloney murine leukemia virus (MuLV). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Involved in spermatogenesis and may play a role in meiotic DNA double-strand break repair. Plays a role in regulating enhancer activation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:21454521}. Nucleus matrix {ECO:0000269|PubMed:19786570}. Cytoplasm {ECO:0000269|PubMed:21454521}. Note=Associated with the nuclear matrix. In testis, localized to heterochromatin of spermatocytes. {ECO:0000269|PubMed:19786570}.
Interaction partners:
- Histone-lysine N-methyltransferase EZH2
- Polycomb protein Suz12
- RING1 and YY1-binding protein
- Histone deacetylase 2
- Histone deacetylase 1
- E3 ubiquitin-protein ligase RING1
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Polycomb complex protein BMI-1
- Transcriptional repressor CTCF
- E3 ubiquitin-protein ligase RING2
Sequence:
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHGGGGGGHGHAGHHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGASSGGGRVKKGGGKKSGKKSYLGGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Protein: 2-methylcitrate dehydratase (2-MC dehydratase) (EC 4.2.1.79) (Aconitate hydratase) (ACN) (Aconitase) (EC 4.2.1.3) (H8F0D6)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity).
Interaction partners:
Sequence:
MVRIMLMHAVRAWRSADDFPCTEHMAYKIAQVAADPVDVDPEVADMVCNRIIDNAAVSAASMVRRPVTVARHQALAHPVRHGAKVFGVEGSYSADWAAWANGVAARELDFHDTFLAADYSHPADNIPPLVAVAQQLGVCGAELIRGLVTAYEIHIDLTRGICLHEHKIDHVAHLGPAVAAGIGTMLRLDQETIYHAIGQALHLTTSTRQSRKGAISSWKAFAPAHAGKVGIEAVDRAMRGEGSPAPIWEGEDGVIAWLLAGPEHTYRVPLPAPGEPKRAILDSYTKQHSAEYQSQAPIDLACRLRERIGDLDQIASIVLHTSHHTHVVIGTGSGDPQKFDPDASRETLDHSLPYIFAVALQDGCWHHERSYAPERARRSDTVALWHKISTVEDPEWTRRYHCADPAKKAFGARAEVTLHSGEVIVDELAVADAHPLGTRPFERKQYVEKFTELADGVVEPVEQQRFLAVVESLADLESGAVGGLNVLVDPRVLDKAPVIPPGIFR
Protein: RRM domain-containing protein (Q3V2M1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNSSDPGCPMASLYVGDLHPDVTEAMLYEKFSSAGPILSIRVYRDVITRRSLGYASVNFEQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRRSGVGNVFIKNLNKTIDNKALYDTFSAFGNILSCKVVSDENGSKGHGFVHFETEEAAERAIEKMNGMLLNDRKVFVGRFKSQKEREAELGTGTKEFTNVYIKNFGDRMDDETLNGLFGRFGQILSVKVMTDEGGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKHIYVGRA
Protein: Core binding factor beta subunit isoform 2 (Core-binding factor subunit beta) (A0A0B4P506)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPANLHGDQRQAPTREYVDFERETGKVYLKAPMILNGVCVIWRGWLDLHRLDGMGCLEYDDERAQHEDALAQAAFEEARRRTRDFEDRDRSHREDLEDPVASKIWD
Protein: Inhibitor of apoptosis protein (IAP) (P69180)
Organism: African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Function: Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation to promote the viral replication. Induces also the activation of host NF-kappaB.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:8553574}. Virion {ECO:0000269|PubMed:30185597}. Note=Probably accumulates in the perinuclear cytoplasmic viral factories. Found in association with viral nucleoid (PubMed:30185597). {ECO:0000269|PubMed:30185597}.
Interaction partners:
Sequence:
MFPKINTIDPYISLRLFEVKPKYVGYSSIDARNQSFAIHGIKNYEKFSNAGFFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL
Protein: ENAH, actin regulator (A0A8I5ZT50)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEEMEIQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQDRERERERLEQLEREQVEWERERRMSNAAPSSDSSLYSAPLPEYSSCQPPSAPPPSYAKVISAPVSDAAPDYAVVTALPPTSTPPTPPLRHSATRFATSLGSAFHPVLPHYATVPRPLNRNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPPPPPPPPPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAAAPASVETPLNPELGDSSASEPGLQAASQPAETPAPQGHVLGPPAPPPPPPLPSGPAYASALPPPPGPPPPPPLPSAGPPPPPPPPPPLPNQVPPPPPPPPAPPLPASGIFSGSMSEDNRPLTGLAAAIAGAKLRKVSRVEDGSFPSGGNTVSVNLASSKTDSGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRSEDAEPVTSKAASTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELSKSNTA
Protein: Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Q16828)
Organism: Homo sapiens (Human)
Function: Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8670865}.
Interaction partners:
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Protein sprouty homolog 2
- Protein sprouty homolog 4
- Protein c-Fos
- Early growth response protein 1
- Mitogen-activated protein kinase 7
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
Protein: SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2) (Q8CD91)
Organism: Mus musculus (Mouse)
Function: Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:18757743}.
Interaction partners:
Sequence:
MLPPQLCWLPLLAALLPPVPAQKFSALTFLRVDQDKDRDCSLDCPSSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAHRGNCKDVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSINEKVPQREGAGKADDAAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSASSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKNRPLQGCPGAKKHEFLTSVLDALSTDMVHAVSDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDMNNDKSITVQELMGCLGVTREEGKANTRKRHTPRGNAESSSSNRQPRKQG
Protein: Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Q3UTQ8)
Organism: Mus musculus (Mouse)
Function: Mediates phosphorylation of MECP2. May regulate ciliogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O76039}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:O76039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O76039}.
Interaction partners:
- Methyl-CpG-binding protein 2
- Forkhead box protein G1
- Protocadherin-19
- Syntaxin-binding protein 1
- Sodium channel protein type 1 subunit alpha
- Potassium voltage-gated channel subfamily KQT member 2
Sequence:
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRNQSTKGAALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGASSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHADQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQQAKNSFSEIRIHPLSQATGGSSNIRQEPTPKGRPALQLPGSSLLRYNGWKHSRSRSSQPDEVIFLASHEKWKQ
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (Q7DC82)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- anthranilate synthase
- Probable pyridoxamine 5'-phosphate oxidase
- Trans-2,3-dihydro-3-hydroxyanthranilate isomerase
- Phenazine biosynthesis protein PhzD1
- Phenazine biosynthesis protein PhzB1
- Phenazine biosynthesis protein PhzA1
- 3-dehydroquinate synthase
- Phospho-2-dehydro-3-deoxyheptonate aldolase
- 5-methylphenazine-1-carboxylate 1-monooxygenase
- Phenazine biosynthesis protein PhzB2
Sequence:
MDDLLQRVRRCEALQQPEWGDPSRLRDVQAYLRGSPALIRAGDILALRATLARVARGEALVVQCGDCAEDMDDHHAENVARKAAVLELLAGALRLAGRRPVIRVGRIAGQYAKPRSKPHEQVGEQTLPVYRGDMVNGREAHAEQRRADPQRILKGYAAARNIMRHLGWDAASGQEANASPVWTSHEMLLLDYELSMLREDEQRRVYLGSTHWPWIGERTRQVDGAHVALLAEVLNPVACKVGPEIGRDQLLALCERLDPRREPGRLTLIARMGAQKVGERLPPLVEAVRAAGHPVIWLSDPMHGNTIVAPCGNKTRLVRSIAEEVAAFRLAVSGSGGVAAGLHLETTPDDVTECVADSSGLHQVSRHYTSLCDPRLNPWQALSAVMAWSGAEAIPSATFPLETVA
Protein: Survival motor neuron protein (E7EQZ4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000256|ARBA:ARBA00004216}. Cytoplasmic granule {ECO:0000256|ARBA:ARBA00004463}. Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}. Nucleus, gem {ECO:0000256|ARBA:ARBA00034695}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}.
Interaction partners:
Sequence:
MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMTGFHCVSQDGLNLLTP
Protein: Potassium transporter 4 (AtKT4) (AtKUP3) (AtPOT4) (Q9LD18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity potassium transporter.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- F-box/LRR-repeat protein 4
- Large ribosomal subunit protein eL27y
- F-box/LRR-repeat protein 3
Sequence:
MAPAESGVSPRRNPSQLSWMNLSSNLILAYQSFGVVYGDLSTSPLYVFPSTFIGKLHKHHNEDAVFGAFSLIFWTLTLIPLLKYLLVLLSADDNGEGGTFALYSLLCRHAKLSLLPNQQAADEELSAYKFGPSTDTVTSSPFRTFLEKHKRLRTALLLVVLFGAAMVIGDGVLTPALSVLSSLSGLQATEKNVTDGELLVLACVILVGLFALQHCGTHRVAFMFAPIVIIWLISIFFIGLYNIIRWNPKIIHAVSPLYIIKFFRVTGQDGWISLGGVLLSVTGTEAMFANLGHFTSVSIRVAFAVVVYPCLVVQYMGQAAFLSKNLGSIPNSFYDSVPDPVFWPVFVIATLAAIVGSQAVITTTFSIIKQCHALGCFPRIKVVHTSKHIYGQIYIPEINWILMILTLAMAIGFRDTTLIGNAYGIACMVVMFITTFFMALVIVVVWQKSCFLAALFLGTLWIIEGVYLSAALMKVTEGGWVPFVLTFIFMIAMYVWHYGTRRKYSFDLHNKVSLKWLLGLGPSLGIVRVPGIGLVYSELATGVPAIFSHFVTNLPAFHKVVVFVCVKSVPVPHVSPEERFLIGRVCPKPYRMYRCIVRYGYKDIQREDGDFENQLVQSIAEFIQMEASDLQSSASESQSNDGRMAVLSSQKSLSNSILTVSEVEEIDYADPTIQSSKSMTLQSLRSVYEDEYPQGQVRRRHVRFQLTASSGGMGSSVREELMDLIRAKEAGVAYIMGHSYVKSRKSSSWLKKMAIDIGYSFLRKNCRGPAVALNIPHISLIEVGMIYYV
Protein: Acetylcholine receptor gamma subunit (Q6S3H9)
Organism: Torpedo marmorata (Marbled electric ray)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MVLTLLLIICLALEVRSNEEGRLIEKLLGDYDKRIKPAKTLDHVIDVTLKLTLTNLISLNEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVAYYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAEEGEVVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDIDFQEIIFFLIIQRKPLFYIINIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMFVSLVIVTNCVIVLNVSLRTPNTHSLSEKIKHLFLEFLPKYLGMHLEPSEETPEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLYKDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSLGTLAIFLTGHLNQVPEFPFPGDPRKYVP
Protein: Dilute class unconventional myosin, isoform A (A1Z6Z9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTKI
Protein: ERMES regulator 1 (Q3E828)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediates the formation of endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) foci, thereby contributing to the formation of ER-mitochondrial contact sites.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:26928762}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q4ZGE1}.
Interaction partners:
- Mitofissin
- Cx9C motif-containing protein 4
- RDS3 complex subunit 10
- Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit
- Sporulation protein 24
Sequence:
MIFFFNQIRSIFTALHTPTQQIQLSRRAFFQFLGYLGSCVVISLAAQSKYVQ
Protein: Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) (Q9NU02)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITFIPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT
Protein: Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) (P11441)
Organism: Homo sapiens (Human)
Function: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303}. Nucleus {ECO:0000269|PubMed:21636303}.
Interaction partners:
- ATPase GET3
- Golgi to ER traffic protein 4 homolog
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Large proline-rich protein BAG6
- FAS-associated factor 2
- Guided entry of tail-anchored proteins factor 1
- P3 protein
- Guided entry of tail-anchored proteins factor CAMLG
- Small ribosomal subunit protein eS19
- E3 ubiquitin-protein ligase AMFR
Sequence:
MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRFLHPEVTETMEKGFSK
Protein: Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B) (Q96PX9)
Organism: Homo sapiens (Human)
Subcellular location: Basal cell membrane {ECO:0000269|PubMed:33310911, ECO:0000269|PubMed:38088892}. Cell junction {ECO:0000269|PubMed:33310911, ECO:0000269|PubMed:38088892}. Nucleus {ECO:0000269|PubMed:33310911}. Cytoplasm {ECO:0000269|PubMed:33310911}. Note=Located at the basal plane of cell-cell junctions (PubMed:33310911). Intracellular Ca(2+) concentration is a key factor in regulating PLEKHG4B localization; it diffusely distributes in the cytoplasm under low Ca(2+) conditions, localizes to the basal membrane under normal Ca(2+) conditions, and accumulates at the cell-cell junction under higher Ca(2+) conditions (PubMed:38088892). {ECO:0000269|PubMed:33310911, ECO:0000269|PubMed:38088892}.
Interaction partners:
Sequence:
MGFSTADGGGGPGARDLESLDACIQRTLSALYPPFEATAATVLWQLFSVAERCHGGDGLHCLTSFLLPAKRALQHLQQEACARYRGLVFLHPGWPLCAHEKVVVQLASLHGVRLQPGDFYLQVTSAGKQSARLVLKCLSRLGRGTEEVTVPEAMYGCVFTGAFLEWVNRERRHVPLQTCLLTSGLAVHRAPWSDVTDPVFVPSPGAILQSYSSCTGPERLPSSPSEAPVPTQATAGPHFQGSASCPDTLTSPCRRGHTGSDQLRHLPYPERAELGSPRTLSGSSDRDFEKVSPSEQGPRMPPENCGGSGERPDPMDQEDRPKALTFHTDLGIPSSRRRPPGDPTCVQPRRWFRESYMEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGLQLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEACPSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEEALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGAPAVLLSRTRQA
Protein: 60S ribosomal export protein NMD3 (Q57VU3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU364108}. Nucleus {ECO:0000256|RuleBase:RU364108}.
Interaction partners:
- Aminopeptidase, putative
- Eukaryotic translation initiation factor 6
- Nucleolar GTP-binding protein 1
- 60S ribosomal protein L10, putative
- 60S ribosomal protein L24, putative
- Uncharacterized protein
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L7a
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L2, putative
Sequence:
MDLDDEFITNRSEATIPKVLCCVCGLLIDSNPSNMCSSCLRSHVDITESVQKEYIIVYCPECSRYLQPPQYWTRADLESRELLTICLKRVKGLSRNVFKLVDAKFIWTEPHSKRLKVKLVLQKEVMSNIVIQQACVIEYVVVWQQCPTCQKVATGQPQWDACVQLRQKVAHKKTFLYLEQLILKHKLQENFIRVEAQPDGLDFFFAHKSHALNFLEFVSRNSPVTRRDAVQLVSHDSKNNTAVQHHTFSLEIAPLCREDLVLLPYQSYYLKLGGLGPLVLVHKVYSSVVLVDPRTLRANEFTGTYYWKKPFLPLMNSREMTEFYVLQCTPTGVTNGRYHLGVITVCLSSEVGYGREWIVTSHLGGLLQPGDLAMGYLLEGRTFNHEEWENNKYKQDQLQEVVLVRKHFPAQRARRHRRNWKLKRLDVMDPSCAERNARRQEEQEEERLEFEDELERDVELRRDVPIYKMLDSELAERVVKKNEGKGNANPENECDDDADEAPQIALEEMLDELRLSDDDETAAADDEEASVENARKKKRPEV