wanglab/gogpt-training-data huggingface dataset:
Protein: Alanine dehydrogenase (EC 1.4.1.1) (P17556)
Organism: Lysinibacillus sphaericus (Bacillus sphaericus)
Function: Catalyzes the reversible reductive amination of pyruvate to L-alanine. Prefers L-alanine for oxidative deamination, other substrates are poorly reactive. In the other direction 2-oxobutyrate is almost as reactive as pyruvate. Ammonia is the sole amino donor for the reductive amination of pyruvate, NADPH is inert. Reductive amination proceeds through a sequential, ordered ternary-binary mechanism, where NADH binds first followed by ammonia and pyruvate; the products are released in the order L-alanine and NAD(+). A key factor in the assimilation of L-alanine as an energy source via the tricarboxylic acid cycle during sporulation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0QVQ8}.
Interaction partners:
- Alanine racemase
Sequence:
MKIGIPKEIKNNENRVAMTPAGVVSLTHAGHERLAIETGGGIGSSFTDAEYVAAGAAYRCIGKEAWAQEMILKVKEPVASEYDYFYEGQILFTYLHLAPRAELTQALIDKKVVGIAYETVQLANGSLPLLTPMSEVAGKMATQIGAQYLEKNHGGKGILLGGVSGVHARKVTVIGGGIAGTNAAKIAVGMGADVTVIDLSPERLRQLEDMFGRDVQTLMSNPYNIAESVKHSDLVVGAVLIPGAKAPKLVSEEMIQSMQPGSVVVDIAIDQGGIFATSDRVTTHDDPTYVKHGVVHYAVANMPGAVPRTSTIALTNNTIPYALQIANKGYKQACIDNPALKKGVNALEGHITYKAVAEAQGLPYVNVDELIQ
Protein: Viral IRF4-like protein (vIRF-4) (Q2HR73)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Plays a role in host cell apoptosis modulation by promoting TP53/p53 ubiquitination and subsequent degradation and thus down-regulating TP53/p53-mediated apoptosis. Works as a potential viral transcription factor to modulate host gene expression to build favorable environments for the viral lytic life cycle and greatly accelerates the induction of an immediate early gene RTA, early genes ORF36 and ORF57, late genes ORF25 and ORF64, and latent genes LANA1 and v-IRF3. Inhibits host interferon-alpha production by interacting with host IRF7 and preventing IRF7 dimerization.
Subcellular location: Host nucleus.
Interaction partners:
Sequence:
MPKAGGSEWATLWIIDALENNKFPYFSWFDRNNLLFAAPAPLPAGSDIPPGWYSVYHAFDEECDRVYGPSPVVGQTVYGRFGRLLRGTRRAVVRNDLRYSDTFGGSYVVWQLVRTPFKNCTYCYGAAYGPEKLQRFIQCLLSPPMQTTATRRSDTREQSYEEAGAAAPAPPKAPSGLRGRPRKSNRYYNVGDITTEQKAACSVWIPVNEGASTSGMGSSGTRQVTQASSFTWRVPGDPPAPSTLTGPSDPHSSGAGLPGTAPPKPQHETRLAGTVSGVSGVAQTPGDTGQLAPPMRDGSRLPSTSPWIPACFPWGDLPVTGWWPQGASGLPEKVHPPTTGQFDPLSPRWTYTGIPSSQLNPAAPSWIPPHAQAGTFVGEFSQGAPLAPQGLLPQSGQCASAWLPRRETGAEGACGASTEGRAPQGAASERVYPFEPQPPSAPAPGYAKPSCYNWSPLAEPPATRPIRAPVWHPPVGHAVVPEVRTPLWIPWSSGGAPNQGLSHTQGGASATPSAGAPPTPEVAERQEPSSSGIPYVCQGDNMATGYRRVTTSSGALEVEIIDLTGDSDTPSTTVASTPLPVSGPRVFQPTVLYSAPEPAVNPEVSHLPTELERRECVCPGSGERPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRTPVSHSGPEKPPSKMFFDPPDSQRVSFVVEIFVYGNLRGTLRREGDAGEAMLCSWPVGDTLGHLCQSFVPELLRIPRLTVPSPEQMEILNRVFEGLGHGFPIFCSMSGIYSRNATQVEGWWFGNPNSRYERILRSFSPRVPQQLFNTARYLATTAAIPQTPLSVNPVTCGTVFFGASPASTENFQNVPLTVKIFIGSIWDSLH
Protein: Mitoguardin 1 (Protein FAM73A) (Q4QQM5)
Organism: Mus musculus (Mouse)
Function: Regulator of mitochondrial fusion. Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8NAN2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitoguardin 2
Sequence:
MSDETVSRSQFSLKTYAVRVFALPVSWYYSLSQIKFSPVAKKLFMVTAVSAVSVIFLAHHFKRRRGKQKGKVLPWEPEHLLLEHTRRAASEKGSSCSSSRQNLTLSLSSTKEKGSQCCNYPNGGLLSRYSGSAQSLGSVQSVNSCHSCACGNSNSWDKADDDDIRLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRSRQAEDEACSSVKLGAGDAIAEESVDDIISSEFIHKLEALLQRAYRLQEEFEATLGGSDPNSIANDTDKDTDMSLRETMDELGLPDAMNMDSADLFASATELAEQREAQQTFSLESFCPCPFYEEAMHLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQLILAEADNRSFLAESGRKILSALIVKARKNPKKFQDVFDEMINFLEQTDHWDSTELELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQSVVNNRWLNSSFKESAVASSCWSVLKQKRQQMKISDGFFAHFYAICEHVSPVLAWGFLGPRNSLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIDTLAEDLTHLLIRRTELLVTCLGADALRHATTCTSGHSHAVPTALLEAKVQ
Protein: Kinesin-related protein (O42263)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSEGDAVKVCVRVRPLIQREQGDQANLQWKAGNNTISQVDGTKSFNFDRVFNSHESTSQIYQEIAVPIIRSALQGYNGTIFAYGQTSSGKTYTMMGTPNSLGIIPQAIQEVFKIIQEIPNREFLLRVSYMEIYNETVKDLLCDDRRKKPLEIREDFNRNVYVADLTEELVMVPEHVIQWIKKGEKNRHYGETKMNDHSSRSHTIFRMIVESRDRNDPTNSENCDGAVMVSHLNLVDLAGSERASQTGAEGVRLKEGCNINRSLFILGQVIKKLSDGQAGGFINYRDSKLTRILQNSLGGNAKTVIICTITPVSFDETLSTLQFASTAKHVRNTPHVNEVLDDEALLKRYRKEILDLKKQLENLESSSETKAQAMAKEEHTQLLAEIKQLHKEREDRIWHLTNIVVASSQESQQDQRVKRKRRVTWAPGKIQNSLHASGVSDFDMLSRLPGNFSKKAKFSDMPSFPEIDDSVCTEFSDFDDALSMMDSNGIDAEWNLASKVTHREKTSLHQSMIDFGQISDSVQFHDSSKENQLQYLPKDSGDMAECRKASFEKEITSLQQQLQSKEEEKKELVQSFELKIAELEEQLSVKAKNLEMVTNSREHSINAEVQTDVEKEVVRKEMSVLGDSGYNASNSDLQDSSVDGKRLSSSHDECIEHRKMLEQKIVDLEEFIENLNKKSENDKQKSSEQDFMESIQLCEAIMAEKANALEELALMRDNFDNIILENETLKREIADLERSLKENQETNEFEILEKETQKEHEAQLIHEIGSLKKLVENAEMYNQNLEEDLETKTKLLKEQEIQLAELRKRADNLQKKVRNFDLSVSMGDSEKLCEEIFQLKQSLSDAEAVTRDAQKECSFLRSENLELKEKMEDTSNWYNQKEKAASLFEKQLETEKSNYKKMEADLQKELQSAFNEINYLNGLLAGKVPRDLLSRVELEKKVSEFSKQLEKALEEKNALENEVTCLSEYKFLPNEVECLKNQISKASEEIMLLKQEGEHSASIISKQEIIMQEQSEQILQLTDEVTHTQSKVQQTEEQYLEMKKMHDDLFEKYIRNKSEAEDLLREMENLKGTMESVEVKIADTKHELEETIRDKEQLLHEKKYFFQAMQTIFPITPLSDSLPPSKLVEGNSQDPIEINDYHNLIALATERNNIMVCLETERNSLKEQVIDLNTQLQSLQAQSIEKSDLQKPKQDLEEGEVKLLLEMELLKGHLTDSQLSIEKLQLENLEVTEKLQTLQEEMKNITIERNELQTNFEDLKAEHDSLKQDLSENIEQSIETQDELRAAQEELREQKQLVDSFRQQLLDCSVGISSPNHDAVANQEKVSLGEVNSLQSEMLRGERDELQTSCKALVSELELLRAHVKSVEGENLEITKKLNGLEKEILGKSEESEVLKSMLENLKEDNNKLKEQAEEYSSKENQFSLEEVFSGSQKLVDEIEVLKAQLKAAEERLEIKDRDYFELVQTANTNLVEGKLETPLQADHEEDSIDRRSEEMEIKVLGEKLERNQYLLERLQEEKLELSNKLEILQKEMETSVLLKDDLQQKLESLLSENIILKENIDTTLKHHSDTQAQLQKTQQELQLAKNLAIAASDNCPITQEKETSADCVHPLEEKILLLTEELHQKTNEQEKLLHEKNELEQAQVELKCEVEHLMKSMIESKSSLESLQHEKHDTEQQLLALKQQMQVVTQEKKELQQTHEHLTAEVDHLKENIELGLNFKNEAQQKTTKEQCLLNENKELEQSQHRLQCEIEELMKSLKDKESALETLKESEQKVINLNQEMEMVMLEMEELKNSQRTVIAERDQLQDDLRESVEMSIETQDDLRKAQEALQQQKDKVQELTSQISVLQEKISLLENQMLYNVATVKETLSERDDLNQSKQHLFSEIETLSLSLKEKEFALEQAEKDKADAARKTIDITEKISNIEEQLLQQATNLKETLYERESLIQCKEQLALNTEHLRETLKSKDLALGKMEQERDEAANKVIALTEKMSSLEEQINENVTTLKEGEGEKETFYLQRPSKQQSSSQMEELRESLKTKDLQLEEAEKEISEATNEIKNLTAKISSLEEEILQNASILNEAVSERENLRHSKQQLVSELEQLSLTLKSRDHAFAQSKREKDEAVNKIASLAEEIKILTKEMDEFRDSKESLQEQSSHLSEELCTYKTELQMLKQQKEDINNKLAEKVKEVDELLQHLSSLKEQLDQIQMELRNEKLRNYELCEKMDIMEKEISVLRLMQNEPQQEEDDVAERMDILESRNQEIQELMEKISAVYSEQHTLLSSLSSELQKETEAHKHCMLNIKESLSSTLSRSFGSLQTEHVKLNTQLQTLLNKFKVVYRTAAVKEDHSLIKDYEKDLAAEQKRHDELRLQLQCLEQHGRKWSDSASEELKFCEIEFLNELLFKKANIIQSVQDDFSEVQVFLNQVGSTLQEELEHKKGFMQWLEEFGDLHVDAKKLSEGMQQENRRIASTIQLLTKRLKAVVQSKIQREITVYLNQFEAKLQEKKEQNKELMRRMEHHGPSASVMEEENARLLGILKTVQDESKKLQSRIKMLENELNLVKDDAMHKGEKVAILQDKLLSRNAEAELNAMQVKLTKKQDNLQAAMKEIENLQKMVAKGAVPYKEEIDNLKTKVVKIEMEKIKYSKATDQEIAYLKSCLEDKEEGLRRLKEELRRAQADNDTTVCVPKDYQKASTFPVTCGGGSGIVQSTAMLVLQSEKAALERELSHYKKKYHHLSRTMSSSEDRKKTKAKSDAHSSHTGSSHRGSPHKTETYRHGPVTPERSEMPSLHLGSPKKSESSTKRVVSPNRSEIYSQLVMSPGKTGMHKHILSPSKVGLHKKRALSPNRSEMPTQHVISPGKTGLHKNLTESTLFDNLSSPCKQQKVQENLNSPKGKLFDVKSKSMPYCPSQFFDNSKLGDFSELNTAESNDKSQAENWWYEAKKETAPECKTS
Protein: Dedicator of cytokinesis 4 (A0A590UJ51)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSILLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLPRKVSQL
Protein: Probable MFS dicarboxylate transporter (Q9HT43)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- MifR
- C4-dicarboxylate transport protein 2
- C4-dicarboxylate transport transcriptional regulatory protein DctD
Sequence:
MESANAISASAQPRTTSQRIKSIFSGSVGNLVEWYDWYVYAAFSLYFAKAFFPQGDMTAQLLNTAAIFAVGFLMRPIGGWLMGIYADRKGRKAALLASVLLMCFGSLIIALTPSYETIGVAAPILLVVARLLQGLSVGGEYGTSATYLSEMANKEQRGFFSSFQYVTLISGQLIALAVLIVLQQTLTVEQLESWGWRVPFFIGALCAVVAMFLRRGMEETESFSKKKEEPKESLLRTLLRHPKEVLTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSKTDSTMISAATLFLFMLLQPIVGALSDKIGRRPILIAFGVLGTVFTYPILSTLHSVDSWWGAFFLIMAALVIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYVALWFKSVGLESGFYWYVTACIACSLLVYVFMKDTQKHSKITTD
Protein: Patched 1 (A0A0G2JVB8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTITQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVRFAVPPGHTNNGSDSSDSEYSSQTTVSGISEELRHYEAQQGTGGPAHQVIVEATENPVFARSTVVHPDSRHQPPLNSRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPSNRDRSGPHGARSHNPRNPTSTAMGSSVPSYCQPITTVTASASVTVAVHPPPGPGRNPRGGPCPGYESYPETDHGVFEDPHVPFHVRCERRDSKVEVIELQDVECEERPWGSSSN
Protein: G-protein-coupled receptor family protein (RpkA) (Q86D86)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSFAGRISLDAFDSSHGGSSESPEIHTLYRVSGSLALLSCIGALFVIITFITIKDLKKHPTRMIFFLSVCDVLFSLKYLVTAVLPHSDSFQTKRVACYLQAGIQQFFGLASIGWSGMISLNLIISTSRPFENSSTYSKFYHGWIWSYSIVTSAILFKNYDVIGPSGDGTCWIKAEDKPLLLMFFIPLLAYFSISISSLIIAAISTRNKSLTSSTTNNSWSDRNRTGMLLRMSTYTLVFILCWAGPLAHRISQIAGHHDAPNQASVLMFFDAIGVSIQGFMNALIWITNPSILRGFLGNIMKYLPFSKKFIKDGENTPLIRSLQDENQDPTQLAVMLRNNILTCSLRGIALSVNDNLNLSNSSSLNNNNNQSHIGGDIHQHLPFDSLSSSSPSSSSTPINHNYNSNNNINNNNNNSNDNFDNINEQFKVYTEKELFKDIFDISPDTNMGSHKFKDYCPNIFAKIRALNNITPSDYLKSFDSSLFFENLSNQKFSEGKSGSFMCFSPDNKFLIKTITRQESVLLKKKINNFYNYLVKNNHSFLLRFYGCHKISMPNDHTIYLAIMSNVFGTIPQGIKIRERYDLKGSKVNRGGNDPLFKGDGLGLDLDFVNFRKFLNLPDGFSHSIIQQLKNDSAFLTSLNIMDYSLLIGVIPNNDDFKKKLIESGGNINNILSGSNLNNNNSNSNSNGIGSGSSGSNFNNNNNGHGSGGLLKGSFTNSSLISNSFDFSNGIISADEKEIYYIGVIDILQLYDFSKKLERFLKVYLFRKDGDGISATRPEPYKQRFLKRMNEIIKNKNYKHKSATQQYNNSIINSNNNYYHNEEEVLFDT
Protein: Coiled-coil domain-containing protein 14 (Q49A88)
Organism: Homo sapiens (Human)
Function: Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle. {ECO:0000269|PubMed:26297806}.
Interaction partners:
- Centrosomal protein of 63 kDa
- Protein moonraker
- Coiled-coil domain-containing protein 18
- Progesterone-induced-blocking factor 1
- Centriole and centriolar satellite protein OFD1
- Coiled-coil domain-containing protein 66
- Centrosomal protein of 72 kDa
- Centrosomal protein of 290 kDa
- Afadin- and alpha-actinin-binding protein
- Centrosome and spindle pole-associated protein 1
Sequence:
MKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQVLSSGRHTGPAKLTNGKKATYLRKIPRFNADSGYSIHSDSESQAETVHGLDGCASLLRDILRNEDSGSETAYLENRSNSRPLESKRYGSKKKRHEKHTIPLVVQKETSSSDNKKQIPNEASARSERDTSDLEQNWSLQDHYRMYSPIIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTDGNSQFASQGKTVSATCTDVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK
Protein: Uncharacterized protein (Q77CB6)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Virion tegument {ECO:0000256|ARBA:ARBA00004535}.
Interaction partners:
Sequence:
MATAALAGDPAPGSRTAARRRRLRLEEAHRREAIFKSRVVDLVRAGADRDDPAFIHAFTAAKAARRDLGGQIRAAARVEAVRQHARDIETRVAAQAAVAAVLAENRRFLRGDFLRAFDDAEDALLDQEERMGDAAADCGGDVGVGGAWLDGDDESLLAQWLLQSAPRVGPDVLSDDWPAAPLGGLAAAPAGARVDAGSAAAAAGQAGPAAAFRERRPPHSTP
Protein: Immunoglobulin heavy variable 3-11 (Ig heavy chain V-III region TRO) (P01762)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
- Immunoglobulin heavy constant delta
- Immunoglobulin lambda-like polypeptide 5
- Immunoglobulin kappa variable 2-40
- Immunoglobulin J chain
- Immunoglobulin kappa variable 2D-29
- Immunoglobulin kappa variable 1-33
- Immunoglobulin lambda variable 10-54.
- Immunoglobulin lambda-like polypeptide 1
- Immunoglobulin kappa variable 2-28
Sequence:
MEFGLSWVFLVAIIKGVQCQVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMSWIRQAPGKGLEWVSYISSSSSYTNYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR
Protein: Probable respiratory nitrate reductase (Gamma chain) NarI (O06562)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Probable respiratory nitrate reductase
- Nitrate reductase alpha subunit
- Probable respiratory nitrate reductase
- Probable nitrate/nitrite transporter NarK2
- Nitrate reductase-like protein NarX
- Nitrate/nitrite transporter
- Probable nitrite extrusion protein 1 NarK1
- Probable integral membrane nitrite extrusion protein NarK3
- Nitrite reductase small subunit
- assimilatory sulfite reductase
Sequence:
MAVLDLVEIFWDAAPYVVVAIAVVGTWWRYRYDKFGWTTRSSQLYESRLLSIGSPMFHFGSLLVIMGHVMGLFIPDSWTRAFGMSDHLYHLQALLLGAPAGFATLLGIGLLIYRRRIQTPVWLATTRNDKLMYLVLVCAIVAGLACTLMGATHEGDMHDYRRSVSVWFRSIWMLAPRGDLMAQATLYYQVHVLIALALFALWPFTRLVHAFSAPIAYLFRPYIVYRSREVAAKHELIGSAPRRRGW
Protein: Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein) (O70326)
Organism: Mus musculus (Mouse)
Function: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Bone morphogenetic protein 4
- Gremlin-2
- Bone morphogenetic protein 7
- Bone morphogenetic protein 6
- Bone morphogenetic protein 5
- Growth/differentiation factor 5
- Growth/differentiation factor 6
Sequence:
MNRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
Protein: Cornetto, isoform B (Q9VS25)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSATLFEMDSQTEEQQQTVCLEEQQLVVGMTSLELSESVVTPGNCDGSDSGLDVASCCHSRITLQRGLSSTSGGYTSSNGLEEIYDSCELKVTTVAQTPSETGSEKTSPPRRTGSVKKKVAMFEPEPTGTPAKDQLRGRVANLKRAESLPRNSAAPGTPGTPSTHRDKARLSTSSFRVPSTTGTPSSSRLARPQKPDTLPNALNRAQSVQRLTQVQRTPSLSRARTPGTPSDDGRWPANRGAARRGMSVTPEVTTNRMRGSPAPGGTLPRRRKQQSVEDLTGGRLSRSNSISRAAIVDARMTSSVMVVPTSRRSLAPAAAKVNSLRRPQPATPRTRIYHETAVQTALTSEDLEQVLGGGLLQTRAVDAVEQRNQSTQAEPDQREFELEQLRHEVRQLSGKLQREREEKLAMQQELHLNTERVMGMLELARVVSASAGTPTSEDSGDGSGHDSLLMLESQIQISGHELFERQQEIGQLRSMCRALQLEMRRSLATQQLLLQEKAAIEQESSELQDFLQHEKAAQCDALRDLEADYQAVKLQLANREEEAKVLRDECRHLVRLNEQRRQENRLLQTKFTALENKSRELIHQQNASVAGASTALSGLHSRLDGLVEQLVYSYSISEQDLEDIRFQAETEHVQNGQRPNGLDLPICPAASGDAIHTLVLASDGSLSPQRNQSFIAAVIGAIRQATTHSGKRLSLRQAGKKNGVGLGSAQAVSAGTQGQEPQGNGDDSDSTEMLDSETEPCLLMMDNVLEDVVHHDSHSHNMVSSCTGMISQIELPTELISQCSHQNNINGGAGGDDSLQQLSQAITNRQQMELHMHKMNGMPMNPRDQCNTEELSCHDSLAELTELPSLMEYSTAQAVVDQVIEVDTLVTKLLKVLRLVQLDNDNCIQQLIVDKNKLQQHKEDMLEKLKDLEDVNLKLQDELMDATQELMIKGSDLSGAKAEMQRHRNEIDVRF
Protein: Disulfide bond formation protein B 2 (Disulfide oxidoreductase 2) (P57701)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity).
Subcellular location: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Thiol:disulfide interchange protein DsbA
- Thiol:disulfide interchange protein DsbG
- Thiol:disulfide interchange protein
- Thiol:disulfide interchange protein DsbE
- Cytochrome c-type biogenesis protein CcmH
- Thioredoxin
- Disulfide bond formation protein B 1
- Flagellar P-ring protein
- Cytochrome c biogenesis ATP-binding export protein CcmA
Sequence:
MSALLKPLDNRLFWPAVAIGGLLILAFVLYLQHVRGFAPCSLCIFIRLDVLGLVLAGIVGSLAPRSRIAGGIAALGMLAASLGGIYHAWSLVAEEKLAAQGMGSCKMFMGFPEWIPLDTWLPQVFQPEGLCGEVVWTLLGQSMAVWSLALFVFCLLVLAAKLAFGRRTA
Protein: Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) (Q61184)
Organism: Mus musculus (Mouse)
Function: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Melatonin-related receptor
- Melatonin receptor type 1B
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLHCQVSAFLMGLSVIGSIFNITGIAMNRYCYICHSLKYDKIYSNKNSLCYVFLIWMLTLIAIMPNLQTGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVLQVRRRVKPDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNLIGLIVASDPATMVPRIPEWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKKIIVSLCTAKMFFVESSNEEADKIKCKPSPLIPNNNLIKVDSV
Protein: ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 4) (E9Q236)
Organism: Mus musculus (Mouse)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15314169}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:15314169}; Multi-pass membrane protein {ECO:0000255}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000269|PubMed:15314169}.
Interaction partners:
- Solute carrier family 22 member 7
- Organic anion transporter 3
Sequence:
MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKCYWKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLDELPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECKKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDITFTSPAVMNTSNGQPSALTIFETAL