wanglab/gogpt-training-data huggingface dataset:
Protein: Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) (Q13231)
Organism: Homo sapiens (Human)
Function: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Subcellular location: Secreted. Lysosome. Note=A small proportion is lysosomal.
Interaction partners:
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- Lysosomal acid glucosylceramidase
- Ceramide glucosyltransferase
- Acidic mammalian chitinase
- N-acylglucosamine 2-epimerase
- N-acetyl-D-glucosamine kinase
- Lysozyme C
- Prosaposin
- Interleukin-13
Sequence:
MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
Protein: Tyrosine-protein kinase receptor (EC 2.7.10.1) (F6P1M3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Nerve growth factor
- Neurotrophin-7
- Brain-derived neurotrophic factor
- Neurotrophin-3
- Epidermal growth factor.
- Insulin
- Growth factor receptor-bound protein 2
- Insulin
- Ephrin-A5b
- Hepatocyte growth factor
Sequence:
MADHRVAPVVGFLLFLVAPVWSGCPSACRCSFAMLQCLESDGITSIPALAAQESENVTEIYIESQPNLENITDVDLANYRELKNLTITDCGLVYISENAFQHNFKLQYVNLASNALTHISWRVFQSVTLLSLILRDNLLTCSCDIYWLQQWHRKRLNEIDSQQNCIYNGSQIPLDSFEMDNCSVPEVMIDPPTVTTQEGGNLTFTCRVTGVPTPTIHWRTEQLRSSWTLEQGIWGSTLEVVLHMRNVSSADNLHNLTCEAENRAGMGDAVVQLDIEFPVRIIYLKNPESQHHWCFPFAVDSNPPASIKWLYNNMPLTETRYAYTELIRDVYDGSQQHGCLFLNKPTHLNNGNYTIIVKNKLGRDQRTVRAKFMDNPFDPSDPEGIIPVLNDDPTAPTNQSTETEKIESRVFGVSVAVGLAVFACTFLLIMVVVINKCGQHSKFGIHRSSVLGTEDDLAVSLRFMNFGASPPSSDDGTLDSGLSSFVENPQYFCGIIKDKDMCVQHIKRKDIVLKWELGEGAFGKVYLAECANLCPDTDKMLVAIKTLKIANESTRQDFQREAELLTVLQHEHIVRFYGVCADGEPLAMVFEYMRHGDLNRFLRAHGPDARILDEMKVPPMGQLTLPQMLHIAAQIASGMVYLASLHFVHRDLATRNCLVGEGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIMYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNSEAIECITQGRELERPRTCPKEVHLLMQGCWQREPQQRLVIKDIYSRLVALVKNPPVYLDILE
Protein: Protein kinase AMP-activated non-catalytic subunit gamma 2 (A0A8I5ZQR3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKRFGSLRGNKKPKDQSRSTQRRQSEPHGLFASSVSSSPSTPTQVTKQHPFPLESYKQEPERLESRIYASSSPPDTGQRFCLAFQSPVRLPLASPTHHAPLRTAALAAAPGPAEAGMLEKLEFQEEAEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPNTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
Protein: Phosphoprotein (P protein) (p23) (p24) (P0C799)
Organism: Borna disease virus (strain V) (BDV)
Function: Essential component of the RNA polymerase transcription and replication complex. Acts as a scaffold which brings L in close proximity to the N-RNA complex. Plays a role in the segregation of the viral genome in host daughter cells during mitosis by interacting with host HMGB1, a host chromatin-remodeling DNA architectural protein, thereby stabilizing RNP on chromosomes. Interacts with host TBK1 and thus interferes with activation of cellular antiviral state. Inhibits cellular histone acetyltransferase activities.
Subcellular location: Host nucleus {ECO:0000269|PubMed:10756058, ECO:0000269|PubMed:12829848, ECO:0000269|PubMed:16414989, ECO:0000269|PubMed:25810554, ECO:0000269|PubMed:9811710}. Host cytoplasm {ECO:0000269|PubMed:12829848, ECO:0000269|PubMed:16414989}. Note=P subcellular localization is modulated by the interaction with protein X. {ECO:0000269|PubMed:12829848}.
Interaction partners:
Sequence:
MATRPSSLVDSLEDEEDPQTLRRERPGSPRPRKVPRNALTQPVDQLLKDLRKNPSMISDPDQRTGREQLSNDELIKKLVTELAENSMIEAEEVRGTLGDISARIEAGFESLSALQVETIQTAQRCDHSDSIRILGENIKILDRSMKTMMETMKLMMEKVDLLYASTAVGTSAPMLPSHPAPPRIYPQLPSAPTTDEWDIIP
Protein: NIP3 homolog (CeBNIP3) (Daf-16/FOXO controlled germline tumor affecting-1) (Q09969)
Organism: Caenorhabditis elegans
Function: Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:25896323}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein lgg-1
- GTP-binding protein Rheb homolog 1
- Serine/threonine-protein kinase pink-1, mitochondrial
- Cell death protein 3
- E3 ubiquitin-protein ligase parkin
Sequence:
MSSFLEFAKPKMLDIKRKINFASGEKTDESVQPQQQTEQSSAQQTTPSAKAVSNPFITPLTESTPGMSESWVELAPSRTSLCSSVDINMVIIDEKDKDSRLSPVSIAQSPHVEFESLEQVKYKLVREMLPPGKNTDWIWDWSSRPENTPPKTVRMVQYGSNLTTPPNSPEPELYQYLPCESDSLFNVRVVFGFLVTNIFSFVVGAAVGFAVCRKLIKHHRQ
Protein: Transcription factor SOX-13 (SRY (Sex determining region Y)-box 13) (mSox13) (Q04891)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3'. Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor. Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells. Required for the differentiation of Vgamma2-positive gamma-delta T-cells, a subset of IL17A expressing gamma-delta T-cells. Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells. Promotes brown adipocyte differentiation. Inhibitor of WNT signaling (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:16835393, ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:9421502}. Cytoplasm {ECO:0000269|PubMed:10871192}.
Interaction partners:
- Transcription factor 7
- Centrosomal protein of 85 kDa
Sequence:
MSMQSPVSVQLAPDSASTMVNCTIKSEEKKEPCHEAPQGAAPAVETQPGDPALASQDATNAKAPPQDCASPESSGSPEPKRPAASEAASGSQERLDFNRNLQEVVPAIEKLLSSDWKERFLGRSNVEAKDVKGTQESLAEKELQLLVMIHQLSALRDQLLTAHSEQKNMAAMLFEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLPVTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRSGVAAHHPLQEPPQPLNLTAKPKVPELPNTSSSPSLKMNSCGPRPASHGAPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQLLHSHSGALENSPNTPFRKDLISLDSSPAKERLEESCVHPLEEAMLSCDMDGSRHFSESRNSSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCVVEGRRLRVGEYKALMRTRRQGARQSYTIPPQAGQAQVSSDILFPRAAGLPLARPLVEHYDPQGLDPNMPVIINTCSLREEGEGTDDRHSVADGEMYRYSEDEDSEGDEKSDEELVVLTD
Protein: NARG2_C domain-containing protein (Q8WQF9)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein
Sequence:
MPDVSVGDETRNSTLPTVCEFVINTPEYCADKDVRIQVPIPLPEYSYLEDWVGKLRAQPSGKFLDYEGAKEALRKFIYSETINHQNRRTISNIECAVKKKREMGMPLFQPSRNRRLLEPRRKPVVPFEEKFTYVVEQSSSENLLTLMRMEVFMKKQMTDMIRARNWEVDQLSKQCEKLVAETGDPDMHPHKISMLNEKLRQVHTTYSFQVADLSDTQKSKYRKAVDSLYSRGSIPAELLDDVILDEHAIPRPVATTTGGYADGVNESFTIYIGSQLKSMHNVCLVTVDRLTDLCQTLEGDWTTSSRLEMATKLYSRNLSGTTLLVPRDPMMHINSSSDFFKICEQSTDLHFDSLAEQLKKTLAANRERNSWKADKIDEETSKLIAEGKTPPEQLVPSSALRQDPTCTVGDVYITRHSNLHKVQIVYHLVVDETLQSLEINSRHPCLAGVRNIIRTAARYNTSTIHIPLLLIDRPDESTTIAWCLKRAEMLFKCVKGYLMEVCSGMDVESLPHYNVHFVLPSGLSPTIYTAITNMFPSIFHLVPGVSS
Protein: Sucrose operon repressor (A0A0H2UR82)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMRELGYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDSEKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAGGVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKEMEIKNILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQLATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI
Protein: P2Y purinoceptor 4 (P2Y4) (Q9JJS7)
Organism: Mus musculus (Mouse)
Function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- P2X purinoceptor 2
- P2X purinoceptor 1
- P2X purinoceptor 6
- P2X purinoceptor
- P2X purinoceptor 7
- P2X purinoceptor 3
- P2X purinoceptor 4
- Guanine nucleotide-binding protein G
- P2Y purinoceptor 13
- P2Y purinoceptor 12
Sequence:
MTSADSLLFTSLGPSPSSGDGDCKFNEEFKFILLPLSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGFCKFVRFLFYWNLYCSVLFLTCISVHRYMGICHPLRAIRWGRPRFAGLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSTIMVLLFGFPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLNAECRVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSTPKRRTTASSLALVTLHEESISRWADIHQDSIFPAYEGDRL
Protein: Cyclic nucleotide-gated potassium channel mll3241 (MlotiK1 channel) (Q98GN8)
Organism: Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Function: Cyclic nucleotide-regulated potassium channel activated by cAMP.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVLAVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGRVLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFGSIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA
Protein: Transmembrane protein 178A (Q9CZ16)
Organism: Mus musculus (Mouse)
Function: Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26644563}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAHLKSGRDSTV
Protein: Shikimate 5-dehydrogenase (EC 1.1.1.25) (P95001)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSEGPKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD
Protein: Large ribosomal subunit protein L37-2 (Large ribosomal subunit protein eL37B) (Probable 60S ribosomal protein L37-B) (Q9W1U6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to the 23S rRNA.
Interaction partners:
- Large ribosomal subunit protein eL38
- 60S ribosomal protein L27
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL5
- IP17351p
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein eL32
- 40S ribosomal protein S15
Sequence:
MTKGTTSFGKRHNKTHTICRRCGNSSYHLQKSKCSQCGYPAAKTRSFNWSRKAKGRKAQGTGRMRYLKNLRRRFRNGLREGGAAKKKTN
Protein: Upstream-binding factor 1-like protein 1 (P0CB47)
Organism: Homo sapiens (Human)
Function: Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q3USZ2}. Nucleus {ECO:0000250|UniProtKB:Q3USZ2, ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Mainly cytoplasmic from the 4-cell stage to the morula stage. Becomes nuclear at the blastocyst stage. {ECO:0000250|UniProtKB:Q3USZ2}.
Interaction partners:
- Transcription factor TFIIIB component B'' homolog
Sequence:
MALPRSQGHWSNKDILRLLECMENNRPSDDNSTFSSTQSHMDWGKVAFKNFSGEMCRLKWLEISCNLRKFGTLKELVLEAKKCVKKMNKSQKYRNGPDFPKRPLTAYNRFFKESWPQYSQMYPGMRSQELTKILSKKYRELPEQMKQKYIQDFRKEKQEFEEKLARFREEHPDLVQKAKKSSVSKRTQNKVQKKFQKNIEEVRSLPKTDRFFKKVKFHGEPQKPPMNGYHKFHQDSWSSKEMQHLSVRERMVEIGRRWQRIPQSQKDHFKSQAEELQKQYKVKLDLWLKTLSPENYAAYKESTYAKGKNMAMTGGPDPRLKQADPQSSSAKGLQEGFGEGQGLQAAGTDSSQTIWVNCHVSMEPEENRKKDREKEESSNSSDCSSGEEIEVDV
Protein: B-cell CLL/lymphoma 6 member B protein (Bcl6-associated zinc finger protein) (O88282)
Organism: Mus musculus (Mouse)
Function: Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.
Subcellular location: Nucleus.
Interaction partners:
- B-cell lymphoma 6 protein homolog
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- ETS translocation variant 5
Sequence:
MGSTAAPEGALGYVREFTRHSSDVLSNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGRAGLGVDVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPVEVEPPRPPTVAPPGSPRRSEGHPDPPTESRSCSQGSPSPASPDPKACNWKKYKFIVLNSQTSQAGSLVGESSGQPCPQARLPSGDEACSSSSSSEEGTTPGLQSRLSLATTTARFKCGALANNSYLFTPRAQETSLPASKQANPPPGSEFFSCQNCEAVAGCSSGLELLAPGDEDKPYKCQLCRSAFRYKGNLASHRTVHTGEKPYRCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHFRHKSQLRLHLRQKHGAATNTKVRYHILGGP
Protein: Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) (Q13621)
Organism: Homo sapiens (Human)
Function: Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:21321328}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP-sensitive inward rectifier potassium channel 1
- Barttin
- Chloride channel protein ClC-Kb
- STE20/SPS1-related proline-alanine-rich protein kinase
- Serine/threonine-protein kinase WNK4
- Chloride channel protein ClC-Ka
- Aquaporin-2
- Serine/threonine-protein kinase WNK1
- Serine/threonine-protein kinase WNK3
- Sodium/hydrogen exchanger 3
Sequence:
MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
Protein: Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase (EC 2.1.1.-) (Q8U4M2)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Interaction partners:
- Small ribosomal subunit protein uS4
- K Homology domain-containing protein
- NOP5/NOP56 related protein
- Small ribosomal subunit protein uS11
- Ribosomal RNA small subunit methyltransferase Nep1
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein eL8
- Elongation factor 2
- Hypothetical GTP-binding protein homolog
Sequence:
MVEVKKHKFPGVYVVIDDDGSEKIATKNLVPGQRVYGERVIKWEGEEYRIWNPHRSKLGAAIVNGLKNFPIKPGKSVLYLGIASGTTASHVSDIVGWEGKIYGIEFSPRVLRELVPIVEERRNIIPILGDATKPEEYRALVTKVDVIFEDVAQPTQAKILIDNAKAYLKRGGYGMIAVKSRSIDVTKEPEQVFKEVERELSEYFEVIERLNLEPYEKDHALFVVRKP
Protein: DNA-directed DNA polymerase eta (A0A1D8PGZ5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Proliferating cell nuclear antigen
- DNA repair protein REV1
- Uncharacterized protein
- DNA polymerase
- HORMA domain-containing protein
- Polyubiquitin
- Postreplication repair E3 ubiquitin-protein ligase RAD18
- DNA polymerase
- Ubiquitin-ribosomal protein eS31 fusion protein
- Uncharacterized protein
Sequence:
MSVKQETRPLTIPLVTNPEVATTLSKFTFQNLDDLNDPKKAYLSPLATIALIDLNAFFAQVEQIRLNLTNQDPVVCAQWNSVIAVSYASRKFGITRMDTIASCKSKCPNVIIAHAAVYKKGESHWAYVEGLPAINKHKVSLDPYRRESRKILRVIGKSFDLTEKASVDECYIDLGREIYKRLIDLFPQLSRGSRDNPENSYANLPLIPPALPLNLKWEGEIINTEKEKSEDNDIVSPPVIEDWDDICFIIGSQILLEVRKDIFEELGYTTSAGLARTKQVAKLAAGFKKPDAQTIIRNSAINSFLTNFELTDVTGMGGKLGESIINKVNVPPQINSISFIRENFSDASIKEKLGGELGLKVYNIVRGINAIELQSTIEVKSMTSTKNFTSFVISNLFDAYDWLKVFAGDLHNRLIDLDNENMELSSTELSNKSKGIMKRPKTLTLGVLSKNGTRQTRQMQIPIHKDLDKMKDIFFENGCVLLREFLEFNTHISLLNNRTPAKEIFIWDPKKVKIMELINMSLTISKFVSVEDRFTLLKTTDTSFNKEEHIAKLFRDYEQAPGTIKYSSPPPPPPPAQKKRSKNGQLDIFESLKKKSKPGDFLEELIKTKKCSRCKLSVDDPVEHNDYHIAMDLSNKLNNH
Protein: Integrator complex subunit 9 (H0YBK3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKISQMCSLPSPPLSFLLEQHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF
Protein: Nematode cuticle collagen N-terminal domain-containing protein (O17642)
Organism: Caenorhabditis elegans
Interaction partners:
- Nematode cuticle collagen N-terminal domain-containing protein
- Cuticle collagen 8
- Nematode cuticle collagen N-terminal domain-containing protein
- Nematode cuticle collagen N-terminal domain-containing protein
- Nematode cuticle collagen N-terminal domain-containing protein
- Sperm-Specific family, class Q
- Nematode cuticle collagen N-terminal domain-containing protein
- Sperm-Specific family, class Q
- Sperm-Specific family, class Q
- Sperm-specific class P protein 34
Sequence:
MEDKAKFAYAADLKKFAFFGVAVSTVATLIAIIAIPLFCVHMQSVTSGLSEELLFCKSKNVYIKGEIEQLSVTREAGRQKRQTPQTCCSCGIGETGPAGVPGQEGAPGNDGKAGQPGAPGADADEQGFHYKAPEFCFDCPAGPPGAVGGPGPKGPPGPPGGPGELGGPGRGGNRGPPGPRGPPGEAGPDGEGGRPGQAGQTRSAPSPPGQPGQPGEPGSPGEPGPDGRAGHPGRNGPPGPPGDNGGQGEPGKDGEDGENGAAGAAGPKGSCDHCPPPRTAPGY
Protein: Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) (Q3TDX8)
Organism: Mus musculus (Mouse)
Function: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS).
Subcellular location: Endoplasmic reticulum. Note=Soluble protein. {ECO:0000250}.
Interaction partners:
- Dihydroorotate dehydrogenase
- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
- Acyl-CoA desaturase 1
- Dihydropyrimidine dehydrogenase [NADP
- Uridine 5'-monophosphate synthase
- Cytochrome b5
- Cytochrome b5 type B
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Fatty acid desaturase 6
- Melanocortin-2 receptor accessory protein 2
Sequence:
MLNVPSQAFPAPGSQQRVSSQGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGGLIEVTEEELKKHNKKEDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQMSDTLPRDVTDTLPREDLSSPSYDWFQTESSVTIVVYTKQKNISLDSVIVDLQDDSLRAEAVIKDHSYLVHVGLSHEVQENFSVRVIENVGKIEIVLQKKESVSWQCLGDHLEKHDSFIPKKDTGLYYRRCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSDSLLSDFKEPVLSPNKYICFLIKIYPAGLFTPELDRLQIGDFISVSGPEGDFKVSKLQEVEDLFLLAAGTGFTPMVTVLNYALSHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALREKRFDVEFVLSAPSPEWNGKQGHISRALLSEFLQRSSENSRAFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA
Protein: Ribosome biogenesis protein enp2 homolog (O74879)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in rRNA-processing and ribosome biosynthesis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 22
- RNA cytidine acetyltransferase
- Uncharacterized protein C18B11.06
- U3 small nucleolar RNA-associated protein 21 homolog
- Ribosome biogenesis protein bms1
- Uncharacterized protein C13G1.09
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 20
- Uncharacterized protein C57A7.06
- Periodic tryptophan protein 2 homolog
Sequence:
MSLKVQNPNNVRVYTVSGEGVTQRLPNWISKRKLKKDYALSHRIELLQDFEYPEASNRIKCTRDGKYAMATGVYKPHIKVFDFAEMSLKFERHTDAENVQFEILSDDWTKSVHLQTDRTVDFHSQGGIHYSTRIPKYGRDLKYHYPNCDLYLAAAGDEVYRLNLEQGRFLNPLKIESAQIDSPTGGVNVIDINPMHQLLAFGTDAGSVEFWDPRDRSRVGILEIPSTVPSTPYSDNSRSVTALKYRNDGLNVAIGLSDGATLLYDLRSSSPYMSKDQGYSMPIKSLHWMDSALDGTARVLSADSKIIKIWEKDTGKPFSSIEPTVELNDVCPIEGTGLILTANEGSPMHAFYIPSLNPAPRWCSFLDNITEEMEENPAPTIYDDYKFVTKKELLNLGLDHLVGTGVIRAYMHGFFIDNNLYEKARLIANPFSYEEHRQKIVKERLEKQRASKIRSQNRPKVNAGLASRLSYQENKLRKKTGVTDGPSILEDERFKNVFTDKEFEVDEDTLEYKQLHPSRSEARGLTAAEESEEEKEHTKGIKFSSDEESLSDMEEENETFDALVDRRKTEQQVSNEKTPQETIRSTPSGMEMTFKVEKKKKSKPVNRDEDSTSGKKKQVTQGRRSASKNVFRNM
Protein: Kinetoplastid kinetochore protein 1 (Q38AX3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDSFASYNTRNQVRRRAASVTARSSLSSGADPSLARSRRQMSISQQPRRLTVRDLWERAPEEDRLLFTQCVRRVQCRLKESLSSMNFLRELASYYTRTAPLINGFPFCVSLSYATFLFHMQMPHVCIEDIQRYAQLIATAIDIIPDTQRSEHPFVRDVIRGDVFGLSSPSLEGPAHYVVLVPSLQYRAFSLLAVTLVEHGVVPVDIINQWQRKLRELCRATSSLVSNRALTLILKTAEEVDREEQVEVLMNVIRSSPRRMHVEQIVACYERLKRAAPCISTGPMYGRSLSIRLTSVFLTLRSPIRKEFVESFLYPSLCSEDVKDTLNQPAVRMHLYRKLLRLCTPGMGTSNPYYLCICAIIQPFLDDVTEGSLEIVSLVKCLMPHAAYFVATLTLDTRLQAEVLAGIVVSLVGSCARVMKRVLMNSPVARAVESPATVYSILFLLREVVRGCSISSSERATLMLQCIGAVANPSVMKTLGKVTKEAFEKFLPSGGDTCNSLVGGGAFPYIVDPQLLCAEMDMVLHGRHVCEAIDIILQHNWNIGSICALCGETRGQSPLCQASGAAHYVGTASLGRVLVTITECAGSEVVREKLKSLMCDSSRRLDSAVHLLLFHIFAHAGPHRKELYLEIEPYIRSTLVEVLNKSRAFGVLDSEERASLLTLHAKLVILLGNAVDRSHVDALLQALSCIQIHSNHDALVLWYLANLLLRRGGSNVDLLPTAPDENNYCVEYPDCAPTCKEAADNAQLLLKIIHRAHYFSPQMRKLVGCCVCKLIQDFNMQADNIITALLSPFGSVPVSLNSLVEYALPVGANSTFWSFFLRQMKTSAPARTALLASFVKSVTRRFSVASPVSCMPITGEETTAELFAVMAYETVRRCPPLARVVLHLLTSWVKQTRSTPGRFVSLVYTSLQMVMVIFRRSVGADVAEVGAETRQDAHHFGEAVSKAVQEIKMQVGRINDMAREIRDENVVFFRLLVRLLKRTKFVVKETVGESCDEIADMLGAGDSLDNEEEEGAGVSVEVCDVAQPDGTPYQGGELFSYSLEELQRPSDDNVFDDLTMSHGDFDAVPAPIPLHLQRRNEQKVEVTLTRRPHANTTFSSQLQDTVTSSADSLSPCSSGGSCGLPPAFDSGTGAADASGRKQGGITPLSKAQERLNESYRQAEGAETILTGRAPTVSKGIQTSPQEGQVKRINPATSPNGQLSNVAASTFPEAVLVESNPGRSKRFSEMLKEASTAIGDIGANSTWHEMSVFSEGDEEPIDDTTVPPLQGTNSANCVTVPSALALQFFATYQTAGDVFDELQRQDERRHYGECAGPPARRQVLATEGERRGDLAVYGFDRGTASQHNLVSTAAVAPHAAILPVVVEGRANNYDLPHSSRPQVPGRLVVAHVNMVNTADRKRAQDGGEAEGSACRMTAEKKNRVEGAGAGNPGQLVTYSPQPEQGQNGGHHDDAKQCYENRGATTTLLPQQETSAALRELEALLGHSGATSVSPTFGGEVATTTSGGVAMFPQGVVPRFFVEQGTGTTTLELRQAMGARDPNGVSSLTNNERRVRGNGIMGANVDGEVGNTWRSDVTAPPVPEYARDPQYSLEIV