wanglab/gogpt-training-data huggingface dataset:
Protein: Protein S100-A6 (Calcyclin) (S100 calcium-binding protein A6) (Q2EN75)
Organism: Sus scrofa (Pig)
Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
Subcellular location: Nucleus envelope {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Calcyclin-binding protein
- Protein S100-A10
- Protein S100-A11
- Annexin A2
- Advanced glycosylation end product-specific receptor
- Protein S100-A13
- Annexin A1
- Protein S100
- Protein S100-A12
Sequence:
MACPLDQAIGLLVAIFHKYSGQEGDKNTLSKSELKELIQKELTIGAKLQDAEIAKLMDDLDRNKDQVVNFQEYVTFLGALAMIYNDVLRG
Protein: Pregnancy specific glycoprotein 19 (F7FEB4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEVSSVLLCSGCSPWQGFLLTASLLTCWLLPTTAQVTLKSSPPQVVEGENVLLSADNLPENIIAFAWYKGETDMNRGIALYSLRYTVSLTGPVHSGRETLYSDGSLWIKNVTQEDTGFYTFRIINNHGKIQSNTTLFLHVKSSLSSCCDPVTSVPLMIEPVPRHAVEGESVLLYVHNLPEALQTFSWYKGVYSLKEFKIAEYSIATKSVFPGPAHRGRATGYTNGSLLLQDLTARDTGLYTLVTLDSNSKIKSAPVQVTPVTQPFLRVTVSTVTVQSSVVFTCLSDNTGVSIRWLFKNRNLQVTERMTLSPSNCQLRIHVVRREDAGQYRCEAFNPISSKTSRPVSLAVISE
Protein: Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) (Q8BGT5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
Interaction partners:
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Glutamate dehydrogenase 1, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
- Alanine--glyoxylate aminotransferase
- N-acetylglutamate synthase, mitochondrial
- Alanine aminotransferase 1
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
Sequence:
MQRAAVLVRRGSCPRASGPWGRSHSSAAAEASAALKVRPERSPRDRILTLESMNPQVKAVEYAVRGPIVLKAGEIEMELQRGIKKPFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLNSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDGVPADPDNIYLTTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAVQVNYYLDEENCWALNVDELRRALRQAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGHEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVDKLKTVLHKVKDFHLKFLEQYS
Protein: Prion-like-(Q/N-rich)-domain-bearing protein (O44606)
Organism: Caenorhabditis elegans
Interaction partners:
- Activated in Blocked Unfolded protein response
Sequence:
MRFTSLAIAFFACALVVSGNVLREKRQCGCAQPQQSQCSCQQVQQTQSCSCQSAPVQQQSPSCSCAQPQQTQNVQVQTTQCAPACQQSCTQQCQAAPSVAQCQPQCQQQCQSQCAPMYNPPATTTPAPVVQCQPMCQQQCQSTCVQQQQPASQCQPQCQQQCNVACDAPATSTQAPQVVHIQLEIQQAQAQCQPQCQQQCQSSCTQQQQPANQCNSACNSQCSNICQQTAQATQQVYNQNSNTNTQMYNPYNNNNQGSGSANCAPACQPACDNSCTSQTPAPMYNPYDASTSAPASSQAVIQIVLQSSVAQSSQCTPQCEQSCQQQCVQQQQPAAQCQSACQDSCSSSCQAAQPATTACQQSPQSPQNSCSCQANYSPCGNGQCCRRK
Protein: Protein G1-like6 (OsG1L6) (Protein ABNORMAL FLOWER AND DWARF 1) (Protein BEAK LIKE SPIKELET 1) (Protein BEAK-SHAPED GRAIN 1) (Protein TRIANGULAR HULL 1) (Q6K5X1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor required for lateral development of the lemma and palea. Involved in the regulation of grain hull development. Possesses transactivation activity in yeast, and may determine grain shape and size by modifying gene expression in the grain hull. Regulates the expression of cell proliferation and expansion related genes. Acts as transcriptional repressor and regulates cell expansion during the lateral development of spikelet. May act upstream of hormone-related genes and starch and sucrose metabolism-related genes, which may be responsible for lemma and palea development, and grain filling, respectively. Does not seem to function at stages of floral-organ initiation and patterning (Ref.9).
Subcellular location: Nucleus {ECO:0000269|PubMed:22203474, ECO:0000269|PubMed:23526395, ECO:0000269|PubMed:26486996, ECO:0000269|PubMed:29057928, ECO:0000269|Ref.9}.
Interaction partners:
Sequence:
MDRHHHHHHHHHHHMMSGGGQDPAAGDGGAGGATQDSFFLGPAAAAMFSGAGSSSSGAGTSAGGGGGGPSPSSSSPSLSRYESQKRRDWNTFGQYLRNHRPPLSLSRCSGAHVLEFLKYMDQFGKTKVHTPVCPFYGHPNPPAPCPCPLRQAWGSLDALIGRLRAAYEENGGTPEMNPFGARAVRLYLREVRETQARARGISYEKKKRKKPSSAGAGAGPSSEGSPPPPGGSASGGGDTSASPQFIIP
Protein: Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) (Q9D6N1)
Organism: Mus musculus (Mouse)
Function: Reversible hydration of carbon dioxide.
Interaction partners:
Sequence:
MARLSWGYGEHNGPIHWNELFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPASAKIISNSGHSFNVDFDDTEDKSVLRGGPLTGNYRLRQFHLHWGSADDHGSEHVVDGVRYAAELHVVHWNSDKYPSFVEAAHESDGLAVLGVFLQIGEHNPQLQKITDILDSIKEKGKQTRFTNFDPLCLLPSSWDYWTYPGSLTVPPLLESVTWIVLKQPISISSQQLARFRSLLCTAEGESAAFLLSNHRPPQPLKGRRVRASFY
Protein: XPA C-terminal domain-containing protein (Q21302)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA repair endonuclease XPF
- ERCC1-like central domain-containing protein
- XPC
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- DNA repair and recombination protein RAD54-like
- DNA mismatch repair proteins mutS family domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- BSD domain-containing protein
- UV excision repair protein RAD23
Sequence:
MPKRRYNPSANEEEKIPIVEKLYRENQESDFLGGGFCDDDDEVQERREQISEMRQKREEAAHNLIQAPENCEKCDKGLMDSWLWERYNCAVCDACRDDKGEHKLLARTEVKNTYLLKDCDLDLRKPKLRYWAKKNPHNPRYGDMKLYLKCQIETRVLEVHGSWEDLELKKELREQSKEVRSEKRFEKKLKDLRQQIRGTSGVKVDFGRPHTHEFGKETHVEEDTWRRTCITCEYEEVFEKL
Protein: Outer spore wall protein LDS2 (Lipid droplets in sporulation protein 2) (Q08218)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in spore wall assembly.
Subcellular location: Prospore membrane {ECO:0000269|PubMed:23966878}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:23966878, ECO:0000269|PubMed:24390141}. Spore wall {ECO:0000269|PubMed:23966878}. Note=Localizes to the ascal side of growing prospore membranes in mid-meiosis II and to the spore wall in post-meiotic cells. Localizes to a specific subset of lipid droplets associated with the exterior surface of the spore throughout spore wall formation. {ECO:0000269|PubMed:23966878, ECO:0000269|PubMed:24390141}.
Interaction partners:
- Outer spore wall protein 6
- Outer spore wall protein 7
Sequence:
MSTRPQPDWYYHRHPYASTPLAEGEEPQLLPIQDQGNHKKSKIWMAYKAPIVRWYKNAMLVKDNFWKDLESSHQIIWYPYKGISESVGNSDYLHLFFLIFGYYLLNLLLIVAFTSILAWSLLVCIYLPFLGLFALPLAYMQTILISTTLCNSMVKGTDFVLFTRIYGVTFARKGLTELSEACETISFTPFVYRRSHRLGGLFSKRFYLVSLPQFFIFFFWYIFIAFMFLLLLLVPIVGPITINMLPFSPGMGFYYFEPYFVDVLHLDSRKLSKVYYKGFAKWLLYSISSGLLESIPILGGLFIGTNAVGASLWIVKEIKDRDQPAVPPSPPAEPEEPTVGSYAPPIQQSIAHINPP
Protein: LH-beta subunit (A5JSW4)
Organism: Hypophthalmichthys nobilis (Bighead carp) (Aristichthys nobilis)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU004069}.
Interaction partners:
Sequence:
MGTPVKMLVVRNNILLLLFCLVVLLVFAQSSFLPPCEPVNETVAVEKEGCPKCLVFQTTICSGHCLTKEPVYKSPFSTVYQHVCTYRDVRYETVRLPDCPPGVDPHITYPVALSCDCSLCTMDTSDCTIESLQPDYCMSQREDFPVY
Protein: viral G-protein coupled receptor (vGPCR) (Protein ORF74) (Q98146)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1.
Subcellular location: Host cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAAEDFLTIFLDDDESWNETLNMSGYDYSGNFSLEVSVCEMTTVVPYTWNVGILSLIFLINVLGNGLVTYIFCKHRSRAGAIDILLLGICLNSLCLSISLLAEVLMFLFPNIISTGLCRLEIFFYYLYVYLDIFSVVCVSLVRYLLVAYSTRSWPKKQSLGWVLTSAALLIALVLSGDACRHRSRVVDPVSKQAMCYENAGNMTADWRLHVRTVSVTAGFLLPLALLILFYALTWCVVRRTKLQARRKVRGVIVAVVLLFFVFCFPYHVLNLLDTLLRRRWIRDSCYTRGLINVGLAVTSLLQALYSAVVPLIYSCLGSLFRQRMYGLFQSLRQSFMSGATT
Protein: ATP synthase subunit alpha (V9HW26)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA
Protein: Tubulin beta-4 chain (Beta-4-tubulin) (P24636)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin alpha-6 chain
- Gamma-tubulin complex component 4
- Tubulin alpha-2 chain
- Tubulin alpha-5 chain
- Protein trichome birefringence-like 26
- Tubulin alpha-1 chain
- Gamma-tubulin complex component 2
- Gamma-tubulin complex component 3
- Senescence/dehydration-associated protein-like protein
- Senescence/dehydration-associated protein-like protein
Sequence:
MREILHIQGGQCGNQIGAKFWEVICDEHGIDHTGQYVGDSPLQLERIDVYFNEASGGKYVPRAVLMDLEPGTMDSLRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENSDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLANPTFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYSALSVPELTQQMWDAKNMMCAADPRHGRYLTASAVFRGKLSTKEVDEQMMNIQNKNSSYFVEWIPNNVKSSVCDIAPKGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDATAGEEEYEEEEEEYET
Protein: Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5KI-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (P70181)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11032811}. Cell membrane {ECO:0000269|PubMed:11032811}. Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
Interaction partners:
- ADP-ribosylation factor 6
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol 4-kinase alpha
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Phosphatidylinositol 4-kinase type 2-alpha
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Phosphatidylinositol 4-kinase type 2-beta
- Synaptojanin-2
- Synaptojanin-1
Sequence:
MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNVPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLDLQDDASVLDVYL
Protein: T cell receptor gamma, variable 5 (A0A0G2JGV5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSTSWLFLLSLTCVYGDSWISQDQLSFTRRPNKTVHISCKLSGVPLHNTIVHWYQLKEGEPLRRIFYGSVKTYKQDKSHSRLEIDEKDDGTFYLIINNVVTSDEATYYCACWD
Protein: Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) (P21399)
Organism: Homo sapiens (Human)
Function: Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:1281544}.
Interaction partners:
- Citrate synthase, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- ATP-citrate synthase
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Isocitrate dehydrogenase subunit beta, mitochondrial
- Isocitrate dehydrogenase subunit gamma, mitochondrial
- Frataxin, mitochondrial
- F-box/LRR-repeat protein 5
- Aconitate hydratase, mitochondrial
Sequence:
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
Protein: Receptor tyrosine-protein kinase erbB-2 (Proto-oncogene c-ErbB-2) (p185erbB2) (B4DTR1)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004199}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004199}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
Sequence:
MELAALCRWGLLLALLPPGAASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Protein: Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (ARTISt/p43) (Acyl coenzyme A thioester hydrolase) (MTE-I) (Very-long-chain acyl-CoA thioesterase) (O55171)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (By similarity). Displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:7744868}.
Interaction partners:
- Cytosolic acyl coenzyme A thioester hydrolase
- Acyl-CoA thioesterase 1
- Acyl-CoA thioesterase 4
- Acyl-coenzyme A thioesterase THEM4
- palmitoyl-CoA hydrolase
- ATP-dependent 6-phosphofructokinase, liver type
- Fructose-1,6-bisphosphatase 1
- Acyl-CoA thioesterase 5
- Fructose-1,6-bisphosphatase isozyme 2
- Acyl-CoA thioesterase 5
Sequence:
MVASSFAVLRASRLCQWGWKSWTQLSGPPPLSTGGRTTFARTNATLSLEPGSRSCWDEPLSITVRGLAPEQPVTLRAALRDEKGALFRAHARYRADAGGELDLARAPALGGSFTGLEPMGLIWAMEPERPLWRLVKRDVQKPYVVELEVLDGHEPDGGQRLAQAVHERHFMAPGVRRVPVRDGRVRATLFLPPEPGPFPEIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTVCYKDETIPPVSLLRDKVKMTKDGLLDVVEALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIICYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVAQLDAWQQLQTFFHKQLSGKS
Protein: Transcriptional regulator (NtrC family) (O67198)
Organism: Aquifex aeolicus (strain VF5)
Interaction partners:
- RNA polymerase sigma factor RpoN
- histidine kinase
- ABC transporter substrate-binding protein
- Ribosomal RNA small subunit methyltransferase I
- Flagellar motor switch protein FliM
- Septum site-determining protein MinD
- Flagellar motor switch protein FliG
- Flagellar biosynthesis protein FlhA
Sequence:
MNVLVIEDDKVFRGLLEEYLSMKGIKVESAERGKEAYKLLSEKHFNVVLLDLLLPDVNGLEILKWIKERSPETEVIVITGHGTIKTAVEAMKMGAYDFLTKPCMLEEIELTINKAIEHRKLRKENELLRREKDLKEEEYVFESPKMKEILEKIKKISCAECPVLITGESGVGKEVVARLIHKLSDRSKEPFVALNVASIPRDIFEAELFGYEKGAFTGAVSSKEGFFELADGGTLFLDEIGELSLEAQAKLLRVIESGKFYRLGGRKEIEVNVRILAATNRNIKELVKEGKFREDLYYRLGVIEIEIPPLRERKEDIIPLANHFLKKFSRKYAKEVEGFTKSAQELLLSYPWYGNVRELKNVIERAVLFSEGKFIDRGELSCLVNSKGIKNKHKSIKEIEKEEIIKVLKEVNFNKKLASEILGIPLRTLYRRLKEYGIE
Protein: Serine protease inhibitor 7 (PIGEN1) (PIG) (STPIA) (STPIB) (pF4) (pKEN14-28) (allergen Sola t 4) (P30941)
Organism: Solanum tuberosum (Potato)
Function: Inhibitor of trypsin (serine protease). May protect the plant by inhibiting proteases of invading organisms (By similarity).
Subcellular location: Vacuole.
Interaction partners:
Sequence:
MKCLFLLCLCLVPIVVFSSTFTSKNPINLPSDATPVLDVAGKELDSRLSYRIISTFWGALGGDVYLGKSPNSDAPCANGIFRYNSDVGPSGTPVRFIGSSSHFGQGIFENELLNIQFAISTSKLCVSYTIWKVGDYDASLGTMLLETGGTIGQADSSWFKIVKSSQFGYNLLYCPVTSTMSCPFSSDDQFCLKVGVVHQNGKRRLALVKDNPLDVSFKQVQ
Protein: Stb6 (WAKL4/Stb6) (A0A1D5VHV3)
Organism: Triticum aestivum (Wheat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSLSCWSWFLAFAWVWCLPLMLMAAEEQQGDGCLAKCGSVTISPPFWLTDWQTGRLCGSPGPLDFELTCYNGSYPLLPSSVPNNAGFAIMDISYEERSLRVVDLRKLQLLHDPPNIFNSCLPMWNTSAKLGRPFKISPVNLELILYNCTEKAAAAARLDKELVQAKTMRCVNTSNTFVHAGVPYDTTGTYSSYALEGCVPIVLPVLRLPSGETNTSHYERLIQSGFLLKWELPPPLPAPAPRNEPPPPPGSERRAKKIILIGITSAAATFLFACLYVLIWHRNGKGLWFFLCKTSSKTEKKYEAMIVSYGSLAPKRYMYSEVMKITSSRNNQLGKGGYGVVFKGKLHDGRLVAVKFLHDCKGNGDEFVNEVMSIGRTSHVNVVSLFGFCLEGSKRALIYEYMPNGSLDKYIYSGSPKEILGWERLYAIAIGIARGLEYLHYSCNTRIIHFDIKPQNILLDRDFSPKIADFGLAKLCHTKESKLSITGARGTIGFIAPEVHSRTFGVVSTKSDVYSYGMMLLEMVGGRRNVRLIAAKSSEKYFPDWIYDHFAQDDGLEACEVTNEIEEIARKMILIGLWCIQVIPLHRPTITKVLEMFERSLDDLDMPPKQNFCELLESSAHNMDVQSGSSTRSEETSLANSKILQQL
Protein: Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like) (Q9CZR3)
Organism: Mus musculus (Mouse)
Function: Potential channel-forming protein implicated in import of protein precursors into mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Sorting and assembly machinery component 50 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM5 homolog
- Mitochondrial import receptor subunit TOM70
- Metaxin-1
- Mitochondrial import receptor subunit TOM40 homolog
- Superoxide dismutase
- Metaxin
- Mitochondrial import receptor subunit TOM20 homolog
Sequence:
MGNTLGLAPMGTLPRRSHRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHTAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSITHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHKANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQADMVFRGLVDSNWCVGAVLEKKMRPLPVTLALGAFLNHWRNRFHCGFSITVG
Protein: Uveal autoantigen with coiled-coil domains and ankyrin repeats (Nuclear membrane-binding protein) (Nucling) (Q8CGB3)
Organism: Mus musculus (Mouse)
Function: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
Subcellular location: Nucleus {ECO:0000269|PubMed:12761289}. Cytoplasm {ECO:0000269|PubMed:12761289}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12761289}. Note=Expressed diffusely in cytoplasm.
Interaction partners:
- Apoptotic protease-activating factor 1
- Caspase-9
- Cytochrome c, somatic
Sequence:
MKSLKSRLWKQDAPGPTSPSSPTAVASTQSAEWNKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAVMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKGPPLQQRNLSHTQDEGSVKSTQREQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKPKSLLAAKEKQHEESLRTIEALKNRFKYFESDHPGPGSYPSNRKEDMLHKQGQMYTTEPQCASPGIPPHMHSRSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKRSHDVNVEDLNKKLSEATQRYAEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGLVC