wanglab/gogpt-training-data huggingface dataset:
Protein: Histone H2B type 2-F (H2B-clustered histone 18) (Q5QNW6)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H2A type 1-C
- Histone H3.2
- Histone H2A type 1
- Histone H3.1
- Histone H2B type 1-O
- Histone H3-like centromeric protein A
- Centromere protein N
- Histone H2A type 1-D
- Histone H2A type 2-A
Sequence:
MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: Probable type II secretion system protein (Q9I5P0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|RuleBase:RU004004}.
Interaction partners:
- Probable type II secretion system protein
- Type II secretion system protein HxcR
- Type II secretion system core protein G
- Type II secretion system protein I
- Type II secretion system protein K
- Probable type II secretion system protein
- Probable type II secretion system protein
- HxcW putative pseudopilin
- Type II secretion system core protein G
- Type II secretion system core protein G
Sequence:
MRQSAFHHARRRWPVLGVALGALLVAACSETPKVPGVPPADEEVGRPLSSVRSGAPLRSADVRERPQAEQARRALSAGRGVARSGGVAPVSATAAELGEQPVSLNFVDTEVEAVVRALSRATGRQFLVDPRVKGKLTLVSEGQVPARTAYRMLTSALRMQGFSVVDVDGVSQVVPEADAKLLGGPVYGADRPAANGMVTRTFRLRYENAVNLIPVLRPIVAQNNPINAYPGNNTVVVTDYAENLDRVAGIIASIDIPSASDTDVVPIQNGIAVDIASTVSELLDSQGSGGAEQGQKTVVLADPRSNSIVIRSPSPERTQLARDLIGKLDSVQSNPGNLHVVYLRNAQATRLAQALRGLITGDSGGEGNEGDQQRARLSGGGMLGGGNSGTGSQGLGSSGNTTGSGSSGLGGSNRSGGAYGAMGSGQGGAGPGAMGEENSAFSAGGVTVQADATTNTLLISAPEPLYRNLREVIDLLDQRRAQVVIESLIVEVSEDDSSEFGIQWQAGNLGGNGVFGGVNFGQSALNTAGKNTIDVLPKGLNIGLVDGTVDIPGIGKILDLKVLARALKSRGGTNVLSTPNLLTLDNESASIMVGQTIPFVSGQYVTDGGGTSNNPFQTIQREDVGLKLNIRPQISEGGTVKLDVYQEVSSVDERASTAAGVVTNKRAIDTSILLDDGQIMVLGGLLQDNVQDNTDGVPGLSSLPGVGSLFRYQKRSRTKTNLMVFLRPYIVRDAAAGRSITLNRYDFIRRAQQRVQPRHDWSVGDMQAPVLPPAQQGIPQAAYDLRPSPRPLRAVPLGEAAPL
Protein: Amino acid ABC transporter, periplasmic substrate-binding protein, putative (Q5LT98)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Interaction partners:
- Cytochrome c550, putative
- YNCE-like beta-propeller domain-containing protein
- Leucine-binding protein domain-containing protein
- MSP domain-containing protein
- Quinoprotein ethanol dehydrogenase
- Efflux ABC transporter, ATP-binding protein
- Transport permease protein
- Regulatory protein, putative
- histidine kinase
- Cytochrome c family protein
Sequence:
MSMARAGTLGAALAVLLLGAGLPAWAQTRCGDHVPQARPQNAGRDIVGADLDAIQERGWIAFAAYEDFAPWSWEENGSVRGVDIELGRLIAEELGVEARFTLVAAGENLEADLRNWVWKGPIVGGRVANVMLHVPYDSNFACRVEQVVFTGQYHVERMGIAFGRAEYPEDKPVPAYFRFDTVGVENDSIADFYLTAFPGGQLRANIRRYPHMGAAMAGLATGEVKTVMGPLAQLEHGLTPELDVHSPPLPGFATGSWTVGVAVHFAYRPLAYAVDDAIVAGIGDGRIGEIFGAYGLTFSPPELR
Protein: NAD-dependent epimerase/dehydratase domain-containing protein (Q581S7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S15, putative
- 40S ribosomal protein S4
- 40S ribosomal protein S25
- 40S ribosomal protein S8
- 40S ribosomal protein S18, putative
- Ribosomal protein S19, putative
- 40S ribosomal protein S16, putative
- Small ribosomal subunit protein uS4
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S24
Sequence:
MLRVFSGSCLSLEHMETVRDFNLVKQPHVLGPGADYFTEDGQPVRPQPCAHTLHKVFSGSTLDLNAACGEILSDEDVALSNGTRGSPHRAGQQGQQQQPKIAPGATVSTILSQLSSETEKERAKSLRSKTVVLIVGGVGYVSSHVVNKALEAGYSVRITGSGALTPQQQAALSSVGRDHEQRLSIFEADMTNTNSLRDALRGCKYVIHCGCPVSSTDKDTVEFHLSAVQALFNAIRQAGKSTVKRVVIHGAASSVFHVTDPEPPSGAFDESCWNSVATNDTDPIPYARIYFEKEAWRLKQMLGVELVVILPSITIGPSRTEEVSDAMKRIQHLATASSYFPYAPNLHWNFVDVRDVAEAHVRALECQEVKDQRVIVSGGCFSFAEIGKLIRNEYPHLTPPTRTANTLMTLIIGATHSQVSIRFLWRTLGVRKCLDTRKATTELGMKFTPMQETLRASIEQMISAGELPPADGSVNARSVSRAGLVVTTMVAGLIGVAAWIVVRRRGKN
Protein: Probable FAD-dependent oxidoreductase PA4991 (EC 1.-.-.-) (Q9HUH4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Probably functions as a FAD-dependent oxidoreductase, whose physiological substrate is unknown. Does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities. Is essential for growth of P.aeruginosa in the sputum of cystic fibrosis patients.
Interaction partners:
- NADP-dependent oxidoreductase domain-containing protein
- Glycine oxidase
- Glutathione reductase
- Uncharacterized protein PA1624
- Knr4/Smi1-like domain-containing protein
Sequence:
MPQALSTDILIVGGGIAGLWLNARLRRAGYATVLVESASLGGGQSVKSQGIIHGGAKYALHGALTGASEAIADMPRRWRACLGSDGELDLRGVRLLSEAHYLWSPGGLAGSLTSFFASKAVRSRVEQAKGEDLPPALRDKGFKGKAYRLTEIVFDVPDLIRRLAELAGDSLLAGERIEPLREGRELAGLCVDGREIRAQRVVLSAGAGNEALLRELGLEQPAMQRRPLHMVMVKAATLKPLYAHCLGAGPKPRITVTTHPTRDGQSVWYLGGDIAETDGVARDEAAQIAEARRELAKLLPWIDLGQAQWATLRVDRAEPAQSNLLRPDNAFLAEQGRLLVGWPTKLALAPDFADRVCARLEEDGIRPSEHAALPQLPRPPLAEPAWEVAFA
Protein: OX-2 membrane glycoprotein (MRC OX-2 antigen) (CD antigen CD200) (P04218)
Organism: Rattus norvegicus (Rat)
Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- CX3C chemokine receptor 1
- CD200 receptor 1-like
- Receptor-type tyrosine-protein phosphatase C
- Cell surface glycoprotein CD200 receptor 1
- Fractalkine
- Tyrosine-protein phosphatase non-receptor type substrate 1
- Triggering receptor expressed on myeloid cells 2
- Leukocyte surface antigen CD47
Sequence:
MGSPVFRRPFCHLSTYSLLWAIAAVALSTAQVEVVTQDERKLLHTTASLRCSLKTTQEPLIVTWQKKKAVGPENMVTYSKAHGVVIQPTYKDRINITELGLLNTSITFWNTTLDDEGCYMCLFNMFGSGKVSGTACLTLYVQPIVHLHYNYFEDHLNITCSATARPAPAISWKGTGSGIENSTESHSHSNGTTSVTSILRVKDPKTQVGKEVICQVLYLGNVIDYKQSLDKGFWFSVPLLLSIVSLVILLVLISILLYWKRHRNQERGESSQGMQRMK
Protein: UDP-glycosyltransferase 75B1 (EC 2.4.1.-) ((Uridine 5'-diphosphate-glucose:indol-3-ylacetyl)-beta-D-glucosyl transferase 1) (IAA-Glu synthase 1) (Indole-3-acetate beta-glucosyltransferase 1) (EC 2.4.1.121) (Q9LR44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses low catalytic activity on indole-3-acetic acid (IAA) in vitro. May transfer UDP-glucose from sucrose synthase to callose synthase for the synthesis of callose at the forming cell plate during cytokinesis. Has high affinity for 4-aminobenzoate. Catalyzes the formation of 4-aminobenzoate glucose ester which represents a storage form of 4-aminobenzoate in the vacuole. Is the major source of this activity in the plant. Also active in vitro on benzoates and benzoate derivatives.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11283335}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:11283335}. Note=During interphase, distributed in a punctate pattern in the perinuclear region. Localized in the forming cell plate during cytokinesis.
Interaction partners:
- Rac-like GTP-binding protein ARAC11
- Callose synthase 1
Sequence:
MAPPHFLLVTFPAQGHVNPSLRFARRLIKRTGARVTFVTCVSVFHNSMIANHNKVENLSFLTFSDGFDDGGISTYEDRQKRSVNLKVNGDKALSDFIEATKNGDSPVTCLIYTILLNWAPKVARRFQLPSALLWIQPALVFNIYYTHFMGNKSVFELPNLSSLEIRDLPSFLTPSNTNKGAYDAFQEMMEFLIKETKPKILINTFDSLEPEALTAFPNIDMVAVGPLLPTEIFSGSTNKSVKDQSSSYTLWLDSKTESSVIYVSFGTMVELSKKQIEELARALIEGKRPFLWVITDKSNRETKTEGEEETEIEKIAGFRHELEEVGMIVSWCSQIEVLSHRAVGCFVTHCGWSSTLESLVLGVPVVAFPMWSDQPTNAKLLEESWKTGVRVRENKDGLVERGEIRRCLEAVMEEKSVELRENAKKWKRLAMEAGREGGSSDKNMEAFVEDICGESLIQNLCEAEEVKVK
Protein: Vitellogenin receptor (Q90W12)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MLTSILEILILRICLQQCGFVHGSKTECEPSQFQCGNGRCIPSVWQCDGDEDCSDGSDENTCVRKTCAEVDFVCRNGQCVPKRWHCDGEPDCEDGSDERVEVCHTRTCRVNEFSCGAGSTQCIPVFWKCDGEKDCDHGEDEMSCGNITCASLEFTCASGRCISLNFVCNGEDDCGDGSDEQECAPSSCGPSEFQCGNATCIPGNWVCDDDVDCQDQSDESPQRCGRQPTPPAKCSSSETQCGSGECIHRKWQCDGDPDCKDGSDEANCSVRTCRPDQFKCEDGNCIHGSRQCNGLRDCADGTDEVNCKNLTQCNGPDKFKCRSGECIEMSKVCNKARDCPDWSDEPINECNLNECLLNNGGCSHICRDMVIGFECDCTPGLQLIDRKTCGDINECMNPGICSQICINLKGGYKCECHNSYQMDPTTGVCKAVGKEPCLIFTNRRDIRKLGLERREYTQIVEQLRNTVALDADFTQQRIFWADLSQRAIFSTVLDKRGDVGSHVKVIDNVTPVGIAVDWIYNNIYWSDLGTKTIEVANFNGTKRKVLFSSGLKEPASIAVDPLSGFLYWSDWGEPATIEKSGMNGVDRQVLVQTDIQWPNGITLDLIKSRLYWVDSKLHMLCSVDLNGDNRRKVLQSPDYLAHPFALTVFEDRVFWTDGENEAIYGANKFTGSDVITLASNLNEPQDIIVYHELIQLSGTNWCNEKGLNGGCAYMCLPAPQINKYSPKYTCACPQDQTLASDALHCRPEANSSTSIHEVNFTARGSTAAWAILPVLLLAMAAAGGYLMWRNWQLKNKKSMNFDNPVYLKTTEEDLNIDISRHTSNIGHTYPAISVVNTEDDCHNQPSK
Protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) (Q8N5C8)
Organism: Homo sapiens (Human)
Function: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.
Interaction partners:
- TNF receptor-associated factor 6
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- NF-kappa-B essential modulator
- Mitogen-activated protein kinase kinase kinase 7
- Receptor-interacting serine/threonine-protein kinase 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- TNF receptor-associated factor 3
- Myeloid differentiation primary response protein MyD88
- Receptor-interacting serine/threonine-protein kinase 2
Sequence:
MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPPKPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
Protein: Rab effector MyRIP (Exophilin-8) (Myosin VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) (A8T6P4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May link secretory vesicles to actin filaments (By similarity). May function as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7}.
Interaction partners:
- Myosin, light chain 12, genome duplicate 2
- TBC1 domain family, member 10Aa.
- Neuron navigator 2b.
- small monomeric GTPase
- SEC23-interacting protein.
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Sequence:
MGRKLDLSGLSNNEAEHVLRVVQRDMQLRKKEEERLSEMKQELEEEGSRCLLLSKQQKFNEHCCIRCCSPFTFLLNPKRQCLDCHYNICKSCCSYSQSERGYICAACQKSRHLRTQSLEWFYNNVKSRFKRFGSAKVLKTLYRKHIIERGALSELPEVSAHEGSNDNGSICDGSDSTLYKQSEGHSMADTLTVALRVAEEAIEEAIAKAENYKDSLEKQNEARYLHEHKEELIEELATTIVQKIIQRGKRPEIQEEYEFVWPQNQKSELPSPTSTQNPLATQNSHSTSQPGAVAQSDISKRSRSAYSSDDSPEKGPEVGMAPGVPKSTEVETDIQNYSSLRRESRALSLPGWKSVDRLENSSASSVLQSPDGNWIALQSSQHSRPSLLTKRKSLVFSVLEKESGVVSAYDEMGSDSDPEDQGGWGAALLQFRRRLSDETYYTDSQHDPEWTFTQHPPITSPSSGQYTNTETLNSDSETSPSPSTRARRAPVMKKGPPETHLYPYYRHPADIVALPQLKPDVLDVNFNPHLGGDSSDGEERSEQVKRSRRRRKSKRETSEHSRAHNALYSAATAENSTVLLNAMMMRRQQSQENTVPLNHQTPDSVTSPDILTFNNMSPEPEYQNTLAHNSSAASLPLLSQLGSNNPGFAPQDPLLRAFPVNETLEEELKYKLSELIGQVSERDVKSSDFEPISEVGNKQEDRVSEKDSGKLRPKERRESKRESKLREMEKQSERQTVKLMDTSDAVRQINIERQMKKERERQRDIERQVERERERQRELEKQIEKDRERRREIEMQVEKKQERQKEMEKQLKQEQERQSEIERDLEKKRKSIRMEKRN
Protein: Protein O-mannosyl-transferase TMEM260 isoform X1 (Transmembrane protein 260) (E7F5M2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSDRWTWSLTGATVAGVSALYVGCAPRAVPGGDSGELITAACELGVAHPPGYPLFTMMSSLMLSLLPLSSPAHSINVLCAVFGAGASGALCFTVCRVAEPGPGAVLAGGVFAVSRLVWQWSVVAEVFSLNNLFVGVLFSLSACFHCADTVQQKKKFALWGALFCGLSLCNQHTLVLYVVVIIPWALLHLYTHNGLSFFDLVSLGTCFLAGFVPYMYLPVSSYLNRARWSWGDQTSVHGLLTHLLRAEYGTFSLAKTNESLNLLEMLRAQWNHCVNDLTVPVLALALLGMLLSLRSRLRCIFVCLIVTMVSIYSVFFAWRANLNIEKPLLLGVVERFWLQADAGVCVLAGLGLSWLVCCLTGHLGKGTVWNTGAWILTAGLISHMISLNHRDCDQSSNDVVDRFSREVVLSLPQGSLVLTRGDLPGNTLRYQHYCQSLRPDLSLVDQEMMTYNWYVAKLQRHLPGVTFPGHRWDPVNAVEKKTFSIEQFLKRNLHRPVFVCIGLTEGDPSWEGSFSRWPWGVCEQLLPVKTPFDPKKWAQKTHNLYNWSEPHDSFHPGSWERVANEEMWQARMKTAFFLFDLAENAEKEQQGRLYEISYKLYCQIVDSQVDYPANWDKNLALAAERLLQSGGRGYGLDSLMSRSIRHFSRYLKREPSDPQSKAIRSIITHLRKEREKFRDRQKA
Protein: Protein ETHYLENE INSENSITIVE 3 (O24606)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor acting as a positive regulator in the ethylene response pathway, by promoting histone acetylation in an ENAP1-dependent manner, thus accelerating the expression of ethylene-responsive genes. Binds DNA. Is required for ethylene responsiveness in adult plant tissues. Binds a primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter with consequence to activate the transcription of this gene.
Subcellular location: Nucleus.
Interaction partners:
- EIN3-binding F-box protein 1
- EIN3-binding F-box protein 2
- Ethylene-insensitive protein 2
- Transcription factor MYC2
- Ethylene-responsive transcription factor 1B
- Mitogen-activated protein kinase 6
- Mitogen-activated protein kinase 3
- Ethylene-responsive transcription factor 2
- Serine/threonine-protein kinase CTR1
- Protein EIN4
Sequence:
MMFNEMGMCGNMDFFSSGSLGEVDFCPVPQAEPDSIVEDDYTDDEIDVDELERRMWRDKMRLKRLKEQDKGKEGVDAAKQRQSQEQARRKKMSRAQDGILKYMLKMMEVCKAQGFVYGIIPENGKPVTGASDNLREWWKDKVRFDRNGPAAITKYQAENNIPGIHEGNNPIGPTPHTLQELQDTTLGSLLSALMQHCDPPQRRFPLEKGVPPPWWPNGKEDWWPQLGLPKDQGPAPYKKPHDLKKAWKVGVLTAVIKHMFPDIAKIRKLVRQSKCLQDKMTAKESATWLAIINQEESLARELYPESCPPLSLSGGSCSLLMNDCSQYDVEGFEKESHYEVEELKPEKVMNSSNFGMVAKMHDFPVKEEVPAGNSEFMRKRKPNRDLNTIMDRTVFTCENLGCAHSEISRGFLDRNSRDNHQLACPHRDSRLPYGAAPSRFHVNEVKPVVGFPQPRPVNSVAQPIDLTGIVPEDGQKMISELMSMYDRNVQSNQTSMVMENQSVSLLQPTVHNHQEHLQFPGNMVEGSFFEDLNIPNRANNNNSSNNQTFFQGNNNNNNVFKFDTADHNNFEAAHNNNNNSSGNRFQLVFDSTPFDMASFDYRDDMSMPGVVGTMDGMQQKQQDVSIWF
Protein: Muscarinic toxin 7 (MT-7) (MT7) (Muscarinic toxin 1) (m1-toxin) (Q8QGR0)
Organism: Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Function: Binds specifically and irreversibly to an allosteric site of the muscarinic acetylcholine M1 receptor (CHRM1) at subnanomolar concentrations and shows a very slow dissociation rate. It also inhibits agonist-mediated guanosine 5'-O-(3'-thiotriphosphate) (GTP-g-S) binding and downstream signaling, and decreases the dissociation rate of orthosteric antagonists (N-methylscopolamine (NMS) or pirenzepine). Is a potent negative allosteric modulator (NAM) for CHRM1 activation and a positive allosteric modulator (PAM) for antagonist binding (Probable).
Subcellular location: Secreted {ECO:0000269|PubMed:8410188}.
Interaction partners:
Sequence:
MKTLLLTLVVVTIVCLDLGYTLTCVKSNSIWFPTSEDCPDGQNLCFKRWQYISPRMYDFTRGCAATCPKAEYRDVINCCGTDKCNK
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (P34943)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- Cytochrome b-c1 complex subunit 9
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Cytochrome b-c1 complex subunit 1, mitochondrial
- NADH-ubiquinone oxidoreductase chain 2
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
Sequence:
MAAAVHPRVVRVLPMSRSSVPALAASVFHSPPQRQLHHAVIPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIVPHRCEPYDTMHLRPMGDLGQIIFMDWNGRDKDSIRRAVEHSSVVINLVGREWETQNFDFEDVFVKIPQAIAQVSKEAGVEKFIHISHLNADIKSSSKYLRSKAVGEKEVRETFPEATIIKPAEIFGREDRFLNYFANIRWFGGVPLISLGKKTVKQPVYIVDVTKGIINAIKDPDARGKTFAFVGPSRYLLFDLVQYVFAVAHRPFLPYPLPHFAYRWIGRLFEISPFEPWTTRDKVERIHTTDKILPHLPGLEDLGVEATPLELKAIEVLRRHRTYRWLSSEIEDVQPAKTIPTSGP
Protein: LDL receptor related protein 8 (A0A8I6AE51)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPARVALSLEDDGLP
Protein: Cis-3-hydroxy-L-proline dehydratase (c3LHyp dehydratase) (c3LHypD) (EC 4.2.1.171) (A0NXQ8)
Organism: Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata)
Function: Catalyzes the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts c3LHyp to L-proline, which allows L.aggregata to grow on c3LHyp as a sole carbon source. Also catalyzes the epimerization of c3LHyp to trans-3-hydroxy-D-proline (t3DHyp), a competing reaction occurring from the same enolate anion intermediate. L-proline, t3LHyp, t4LHyp, c4DHyp and their methylated derivatives are not substrates.
Interaction partners:
Sequence:
MKITAINVFQVDLPLREGRYSWSNGNFVEVFDSTVVEIETDEGLKGYAECCPLGSAYLPSYALGVRSGLQELAPHLIGKDPLNIGEINRVMDAALRGHPYAKAPIDIACWDLLGKATGQPLYTLLGGAAQDDVALYRAISQEAPEIMAKKIEGYAAEGYTKFQLKVGGDANDDINRIHATRSVLKKSDLLVADANTGWTRHEAARVVGAVSSLDVYIEQPCLTYEESVSIRRRTALPFVLDEVIDGPNTLVRGIAEDAMDCINLKISKVGGLTKAKLMRDLCIAHGIPMTIEDTWGGDIVTAAIAHLARSTPSEFTFSATDFNSYGTVDIAEGAPKRVNGRMTTSDLPGLGITPIFDVLGEPVARYS
Protein: Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt) (P43897)
Organism: Homo sapiens (Human)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular location: Mitochondrion.
Interaction partners:
- Elongation factor Tu, mitochondrial
- Small ribosomal subunit protein bS16m
- Elongation factor G, mitochondrial
- Ribosome-recycling factor, mitochondrial
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL27m
Sequence:
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVGSYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFECGEGEEAAETE
Protein: Uncharacterized protein (Q5Q0H6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Histone-lysine N-methyltransferase ATXR7
- Protein MODIFIER OF SNC1 1
- Disease resistance protein RPP4
- CAP superfamily protein
- Probable carboxylesterase 3
- Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
- At5g01740 family protein)
Sequence:
MMGMARKISKEEVVEKLKDDGDFDRLRLKIIRRLKENEDLRNNMISVVKESTSLKRHGAQNMKTRQLSDAIFEEVGSKMLSQLSDGLWGIIRSEDGMKNEIRETVQSVYATLSNPRGEKRGTSAREMEHKIPTPKKEARTDFNTSPASKQKQELIKGAVEDNKGEACSDDVQDNKGEAYNDDEEDPELPPGFG
Protein: Serine/threonine-protein kinase PrkC (Ser/Thr-protein kinase PrkC) (EC 2.7.11.1) (Q81WH6)
Organism: Bacillus anthracis
Function: Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act as spore germinants. Probably autophosphorylates and phosphorylates FusA (EF-G, elongation factor G); the latter modification is likely necessary for germination in response to peptidoglycan.
Subcellular location: Spore membrane; Single-pass type II membrane protein. Note=Is associated with the inner membrane of the spore. {ECO:0000250}.
Interaction partners:
- protein-serine/threonine phosphatase
- Zinc ribbon domain-containing protein
- Protein phosphatase 2C domain-containing protein
- 16S rRNA
- Group-Specific protein
- Serine/threonine protein phosphatase
- Probable dual-specificity RNA methyltransferase RlmN
- Methionyl-tRNA formyltransferase
- Cell-division initiation protein DivIVA
- Chaperonin GroEL
Sequence:
MLIGKRLNDRYKLLKMIGGGGMANVYLAHDDILGRDVAVKILRLDYSNNEEFIKRFHREAQSVTTLSHPNIVNMYDVGEEDGIYYLVMEYVPGQTLKQYIIERGMLPIGEALDIMEQLTSAMAHAHHFEIVHRDIKPHNILIRADGVIKVTDFGIATATSATTITHTNSVLGSVHYLSPEQARGGIANKQSDIYSLGIVMFELLTGRQPFSGESAVAIALKHLQSEIPSPKRWNENIPQSVENIILKATAKDPFHRYQSANAMKRDIETALYPERINEQPFYIPEDMEATKAIPIIQQEQLFENVTDETIVLKGSKVDEQIRKEETDLSKKKKRSNKWLKILITTFLLLAIGITLALTVIPGFFIPKDVKVPDVAGMKYTTAVNTLVEKGFEVTEPNIVYTDDVETGDVIKTDPVAGRVVKENSKITIYQSGGKKKSKMIDFTGKDLESIRTELEEKYKQVTVYYIEDDRPKGAIVEQIPTSDQMVVEAEQELKIWVSKGPYQIRPGDFSRWTENSVTGYLNERKLTPDIKREYSDTVDKGLVISQSPKPGTPLKEGDKVTIIISEGPKPKVTKTVKVDNISIPYESSIIGEKKPQTIEIYKEDMQQKMDRPIETRTISESATISLEFVIQEDTKGRYKIVRDGVTIIDKEVPYPTQ