wanglab/gogpt-training-data huggingface dataset:
Protein: Narrow abdomen, isoform F (A8JUW5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein unc-80 homolog
- Uncoordinated 79, isoform C
- Mid1, isoform A
- Ca2+-channel-protein-beta-subunit, isoform L
Sequence:
MIDRLQIRRLGAAARNKRAGGGGGAGGGAVGSGGAGGGGGGGGAGAVPGAAGAAGTGPITGASATAASGSSGSGGHHQHHHHSHPYSTSGINTPATASTSSSSGNSLTPQQQQQQQHPHHQSHHGHHYAHHQQHTHHHAPPHSHHPHPHPHGHPHSYPHLRHSQPASASQFSFNPSPGSSPGNGLGLGARQDAASALNSPTTIVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGGGGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGWRLVTIDDNKHGGLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSPSAMMSQMIGGSGKLLPFNNQANAVYEVHDWWQEQVLCPQTSDDEI
Protein: Potassium channel subfamily K member (Q3V1G1)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRRGALLASALAAYAGYLALGALLVARLERPHEARLRAELGTLREQLLQHSPCVAAHALDAFVERVLAAGRLGRAALANASGAANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLLTHAPLSWLSLHWGWPPQRAARWHLVALLMVIVAIFFLVPAAVFAYLEEAWSFLDAFYFCFISQSTIGLGDYVPGEAPGQPYRALYKVLVTAYLFLGLVAMVLVLQTFRRVSDLHGLTELILLPDPDPASLSQDEDDQVAVLDARTDLHQHLSAASHADYASIPR
Protein: Integrator complex subunit 7 (Protein deflated) (Q9VT41)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Essential for development. Required for cell signaling and/or cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19326441, ECO:0000269|PubMed:39032490}. Cytoplasm {ECO:0000269|PubMed:19326441}. Note=Predominantly in the nucleus. {ECO:0000269|PubMed:19326441}.
Interaction partners:
- Integrator complex subunit 1
- Integrator complex subunit 4
- Integrator complex subunit 5
- Integrator complex subunit 3
- Integrator complex subunit 2
- Integrator complex subunit 11
- Integrator complex subunit 6
- Integrator complex subunit 9
- Integrator complex subunit 8
- Integrator complex subunit 10
Sequence:
MSHLTGTRVSTFNESFLNENEHDSNAVLMELDKGLRSTKQGIQCEAVVRFPRLFEKYPFPILINSSFIKLADYFVSGSNLLRFWVLRVCQQSENHLDKILNIDSFVRCIFVVMHSNDPVARALLLRTLGAVSRVIPEKQQVHHAIRRALDSHDTVEVEAAIYASSCFAAQSSSFAISMCAKISDMIESLQVPVPMKLLLIPVLRHMHHEATTASLVSRLCMDLLPKYPAQSFVVAIIDTLTQLSSRTLVGVPGQLDVLLDFMQDLRTPVRIQVLRSFNELAGRQSVHAWPKPAIKALIDRFELCTNSKEQFLFLSILLKLSECPLTCQQLLREHRVALLRLCIQCISKLDDYTTATQAMAVLSVLVAFGLKKKGSGEQVDDILHMVNLHMEGLLLCTAKRSECTRDLRRVLTYGIRITKANAEFGTSFIGIVTNSLGDKGAYPPANAELMCEALAGLCEHFQLRKYAFSTAEDLIVDENAMDTDELPPPKINPMLARLPLILHKLNTIIDQENCDQQLRSVEILSSLVLQTTMGCYLPQKVVQCFEKCLGRLNCWTLYRIARTASRYGHHYVAAHIYTKVSQIVISDHMHYFLVALSQISQAECILNYGLEYAYMRDNYAPKVAPEPLIPLMKRLEMASNLYQQALASLRAGSSPQHPCTFQLEYLKIRAQFLQTLHLAVTVKNAQVIVPPPAIAGSLAQNSRDYLQKFGHVTNQLRKLVKALKACEETYARLYKSSFDADHVTLEFLEVAEFQCALFAHIIESICYATPPEPPVFLTTGDHPETRYFAASCQRMEQMQKNLPQEPANAKTISNRHLDVIIAQIEIITKTPLCLPRYFFQILQSTQIKLSVSPQPRSATEPVNVQSGSNLVIKVEGVLQHFSKQKKHFRRVESVQLSLTSQLITPPPRSSQELPKQGANDTVTLNQIVKPQRDFLSGSFLLPISNGGHFQVTLETFVVDENGITWCTGPKSSMVVRVLEDPSKQGAPAPSTSQAVGQTRRF
Protein: CBL-interacting serine/threonine-protein kinase 24 (EC 2.7.11.1) (Protein SALT OVERLY SENSITIVE 2) (SNF1-related kinase 3.11) (Q9LDI3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulatory pathway for the control of intracellular Na(+) and K(+) homeostasis and salt tolerance. Activates the vacuolar H(+)/Ca(2+) antiporter CAX1 and operates in synergy with CBL4/SOS3 to activate the plasma membrane Na(+)/H(+) antiporter SOS1. CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Phosphorylates CBL1, CBL4 and CBL10.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17825054}. Nucleus {ECO:0000269|PubMed:17825054}. Note=Targeted to the cell membrane when interacting with CBL1 or CBL5 and to the tonoplast when interacting with CBL2 orCBL10.
Interaction partners:
- Calcineurin B-like protein 4
- Calcineurin B-like protein 10
- Calcineurin B-like protein 1
- Sodium/hydrogen exchanger 7
- Protein phosphatase 2C 77
- Calcineurin B-like protein 3
- Calcineurin B-like protein 2
- Calcineurin B-like protein 9
- Sodium/hydrogen exchanger 1
- Sodium transporter HKT1
Sequence:
MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSKLENIIWRATEGIPKSEILRTITF
Protein: Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase) (P51649)
Organism: Homo sapiens (Human)
Function: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Subcellular location: Mitochondrion.
Interaction partners:
- 4-aminobutyrate aminotransferase, mitochondrial
- Citrate synthase, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Malate dehydrogenase, mitochondrial
- ATP-citrate synthase
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Pyruvate carboxylase, mitochondrial
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
Sequence:
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Protein: Transcription termination/antitermination protein NusA (P9WIV3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Participates in both transcription termination and antitermination.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00945}.
Interaction partners:
- Ribosome maturation factor RimP
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- Large ribosomal subunit protein uL11
- DNA-directed RNA polymerase subunit omega
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS7
- Transcription termination/antitermination protein NusG
- YlxR domain-containing protein
Sequence:
MNIDMAALHAIEVDRGISVNELLETIKSALLTAYRHTQGHQTDARIEIDRKTGVVRVIARETDEAGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENERTYGEFSTREGEIVAGVIQRDSRANARGLVVVRIGTETKASEGVIPAAEQVPGESYEHGNRLRCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAVRSNVAGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDDDPARFVANALSPAKVVSVSVIDQTARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDAPPPPPGQPEPGVSRGMAHDR
Protein: Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2) (Q925I4)
Organism: Mus musculus (Mouse)
Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Taste receptor type 1 member 3
- Guanine nucleotide-binding protein G
- Taste receptor type 1 member 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel subfamily M member 5
- Taste receptor type 2 member 38
- Sodium/glucose cotransporter 1
- Taste receptor type 2 member 4
- Taste receptor type 2 member 7
Sequence:
MGPQARTLHLLFLLLHALPKPVMLVGNSDFHLAGDYLLGGLFTLHANVKSVSHLSYLQVPKCNEYNMKVLGYNLMQAMRFAVEEINNCSSLLPGVLLGYEMVDVCYLSNNIQPGLYFLSQIDDFLPILKDYSQYRPQVVAVIGPDNSESAITVSNILSYFLVPQVTYSAITDKLRDKRRFPAMLRTVPSATHHIEAMVQLMVHFQWNWIVVLVSDDDYGRENSHLLSQRLTNTGDICIAFQEVLPVPEPNQAVRPEEQDQLDNILDKLRRTSARVVVIFSPELSLHNFFREVLRWNFTGFVWIASESWAIDPVLHNLTELRHTGTFLGVTIQRVSIPGFSQFRVRHDKPEYPMPNETSLRTTCNQDCDACMNITESFNNVLMLSGERVVYSVYSAVYAVAHTLHRLLHCNQVRCTKQIVYPWQLLREIWHVNFTLLGNQLFFDEQGDMPMLLDIIQWQWGLSQNPFQSIASYSPTETRLTYISNVSWYTPNNTVPISMCSKSCQPGQMKKPIGLHPCCFECVDCPPGTYLNRSVDEFNCLSCPGSMWSYKNNIACFKRRLAFLEWHEVPTIVVTILAALGFISTLAILLIFWRHFQTPMVRSAGGPMCFLMLVPLLLAFGMVPVYVGPPTVFSCFCRQAFFTVCFSVCLSCITVRSFQIVCVFKMARRLPSAYGFWMRYHGPYVFVAFITAVKVALVAGNMLATTINPIGRTDPDDPNIIILSCHPNYRNGLLFNTSMDLLLSVLGFSFAYVGKELPTNYNEAKFITLSMTFSFTSSISLCTFMSVHDGVLVTIMDLLVTVLNFLAIGLGYFGPKCYMILFYPERNTSAYFNSMIQGYTMRKS
Protein: Collagen type X alpha 1 chain (A0A0G2K7A5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Aggrecan core protein
- Collagenase 3
- Collagen type IV alpha 1 chain
- Collagen type IV alpha 2 chain
- Transcription factor SOX-9
- Procollagen, type IV, alpha 4
- Collagen type IV alpha 3 chain
- Runt-related transcription factor 2
- Collagen type IV alpha 6 chain
- Hedgehog protein
Sequence:
MLPQIPFLLLVSLTLVHGTFYAERYQTPTGVKSALASPRTQYFIPYPIKGKEISVRGEQGIPGPPGPAGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPGISATGKPGLPGKPGERGPHGHKGDIGPAGLPGPRGPPGPPGIPGPAGISVPGKPGQQGLTGAPGSRGFPGEKGAPGAPGVNGQKGETGYGTPGRPGERGLPGPQGPVGPPGSPGVGRRGENGFPGQPGIKGDRGFPGEAGPPGPPGPQGPPGKQGREGIGKPGATGSPGRPGIPGEKGHPGAPGIAGPPGAPGFGKQGLPGLRGQRGPAGLPGAPGAKGEQGPAGHPGEPGLTGSPGNMGPQGPKGIPGNHGIPGTKGETGLVGPAGPPGARGARGPPGLDGKTGYPGDPGLNGPKGNPGLPGPKGDPGVGGAPGLRGLVGPTGPKGVPGHNGEAGPRGEPGIPGTRGPIGPPGIPGFPGSKGDPGKPGAPGPAGIVTKGLNGPAGPPGRPGPRGHTGEPGLPGPPGPPGPPGPPSQAVIPDGFTKSGQRPRLSGMPLVSANQGVTGMPVSAFTVILSKAYPAVGAPIPFDEILYNRQQHYDPRSGIFTCKIPGIYYFSYHIHVKGTHVWVGLYKNGTPTMYTYDEYSKGYLDQASGSAIMELTENDQVWLQLPNAESNGLYSSEYVHSSFSGFLVAPI
Protein: Rolling pebbles isoform 6 (Q8WS23)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynapse {ECO:0000256|ARBA:ARBA00034110}.
Interaction partners:
Sequence:
MFPLTNRSSSGNRTNNNPSNNNNNQTTSFIIGGTTNINNNNNQLGGTNSAKDKGNFENNWSCNKTTGRRSGSGNSCSFLDLQSIRRLLEHDASGSVCPSCRISFDKGKRRKLIDTCGHERCYSCMFRNDQCPMCMNSSLKDVDGANAQGYDTGIGGSTSTIVSPLGSPQPQLRSHAQRNAALARYMQQHRQESQSPDYHHRYASNGKLPRAAALSTNGNGFTTGTTQTVTVDVHHQLGGGGGGAAAAAKQLMANGISGHSRSSSMSHNIHAAAYSELSAAPPAFATPPTRRRFFNHKNLRSALTGGSGGGSGVGGGVGGAGGVGGGHRRTASNGGCPIDTASILSGDHTHQHHHRDNQPEGKESNALNTSTCSDSAVTRRRRKNVSNHNLKTSARHGASSENRLNRLSLAGTSVYAGHLSSLVFGKIKSLWSVNSSNSSEAGLNQLAGSDAIDHHSSFLNEKLQKDQLHARLGLLLNDPGSNGNSSSSGSGCEPISAHSTTSTTSSSGVGAASTTTSGSSQNVSPEQTLASGAGMLSGSQLSVATSHGVKEDALSLCGKFKAGCSMLHVYEALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAAVQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRVVLINGQPGTGKTAFCLQLVEYSCFGRRQMQDDPDGIYSQLQLGAHCERMRGLASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQMLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQNSQSGSQPQTKFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNICLAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTLLSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKLGPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQSGVLCEVVEVLKRIQTELLTRISISSEDQTGRMSNIGGGASVAYEXHHEITDL
Protein: Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2) (Q8TDI7)
Organism: Homo sapiens (Human)
Function: Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia tips of the cochlear hair cells and plasma membranes of cuticular plates. {ECO:0000250|UniProtKB:Q8R4P4}.
Interaction partners:
- LHFPL tetraspan subfamily member 5 protein
- Calcium and integrin-binding family member 2
- Transmembrane inner ear expressed protein
- Transmembrane channel-like protein 1
- Cadherin-23
- Protocadherin-15
- Calcium and integrin-binding family member 3
- Unconventional myosin-VIIa
- Harmonin
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Sequence:
MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKSAQRPPH
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (Q72F92)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00318}. Secreted {ECO:0000255|HAMAP-Rule:MF_00318}. Cell surface {ECO:0000255|HAMAP-Rule:MF_00318}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. {ECO:0000255|HAMAP-Rule:MF_00318}.
Interaction partners:
- Phosphoglycerate kinase
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
- Pyruvate kinase
- Triosephosphate isomerase
- fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Transketolase
Sequence:
MSTIVSVWAREILDSRGNPTIEVEVSLESGHSGRAAVPSGASTGTREALELRDGDKGRYKGKGVEKAVDNVMGEIAEAVIGLDALRQVQLDNTLLDLDGTDNKERLGANAMLGVSLATARAASSFLGLPLYQYLGGVNAKVLPVPLMNIINGGAHAPNNLDIQEFMIMPIGAATFRDALRMGAETFHTLKALLAADGHVTSVGDEGGFAPNLKSHDEAFKYITRAIEESGYIPGAEIALAIDAAASEFYRDGKYHLAGEGKTFSNSEMTEWLGEFTAKYPLISIEDGLAEGDWEGWGELTYKLGDTVQLVGDDIFVTNPDILAQGIDEGVANSILIKLNQIGTLTETLDTIEMAKQAAYTTVISHRSGETEDHFIADLAVGLNAGQIKTGSLCRSDRLAKYNQLLRIEEDLDDAGIYFGPMIASHFGYEGDEEFEDA
Protein: Shugoshin-1 (Q9P7A0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a central role in chromosome cohesion during meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting centromeric rec8 from separase degradation during anaphase I.
Subcellular location: Nucleus. Chromosome, centromere {ECO:0000269|PubMed:14730319}. Note=Localizes to the centromere. Bub1 is required for centromeric localization (PubMed:14730319). At the onset of anaphase I, it is degraded. {ECO:0000269|PubMed:14730319}.
Interaction partners:
- Meiotic recombination protein rec8
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
- Outer kinetochore KNL1 complex subunit spc7
- Aurora kinase
- Centromere protein mis12
- Inner kinetochore subunit sim4
- Inner kinetochore subunit cnl2
- Inner kinetochore subunit fta6
- Inner kinetochore subunit fta2
- Inner kinetochore subunit mis17
Sequence:
MNFQFINSNINNEDKLPMESLKKKFLKQNREIIKINTQLSIKIRESENEIQDLIQENFTLKSYLVKLEARFRNQSQTEDLLKNFFPEIQTIHKKISQVQSLLKIIEKKCSSDFLEANVKSQFTTCENKDSKEDYQILHNKRLEYVSFNDELKSLETGQPLYCFQDFQKKVHGPPALSEKPGKCILKDKTNAHVNKIPQDEVNYSLPQKNITIFSKELKENEFESINEGETEEEKAKTSNVCVCIPCKSAEQITDLKGQATGDSSPCDFEESQPRINGREKLRRSVKVINYAIPSLRTKLRRDFDLPSDRKRKRHPRGKA
Protein: Protein POOR HOMOLOGOUS SYNAPSIS 1 (Q6W2J0)
Organism: Zea mays (Maize)
Function: Required for accurate chromosome segregation in meiosis. Required for pairing to occur between homologous chromosomes. Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks. Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus. May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19918061}. Note=Localizes to the cytoplasm during leptotene, zygotene and pachytene. {ECO:0000269|PubMed:19918061}.
Interaction partners:
- Trypsin/factor XIIA inhibitor
- 14 kDa zinc-binding protein
- 17.4 kDa class I heat shock protein
Sequence:
MADAADSSMALVHSSLADSVLTSPRTLRQGQKWEVEYARYFGTPRRDPTAAPPSGLRYIMRGVHRHQGTWIPASCPASLCVCHPSLPSAVPVLTISIGDVVFEEHFVSILNFSWPQVTCVTQCPIRGSRVVFVSFCDKFKQIQKFAVRFPQPCDAESFLSCVECSCGSSGTMDIIPFGSDYVCEDSSASEYIVSNGLHHRLDDASNLEEQCFDHTIDEPPMNYHEETDQHVLEPLSASNTSNNSAFPPSFNQMLKSCSIDYDQEEPCPLAASNHVLQEVYVLDTSHDVANEERTAGKGMDAAEGVDASILTYDLMARIKTYMADESFNDMLLKLDKAIDELGGDMSL
Protein: RPGR-interacting protein 1 first C2 domain-containing protein (Q57YZ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MSGRRGTVRSAEEWRDAFYNLDERHRQLQRKLNEQEREMKLLKVSQRRRSAPAAAALPGDANRSTPAVAQAQSGGVREVPSGVKSRLEDPVGLSTENSRGRNPERSVQFVGVPSAARREDAAAAAAEIANIYSGAPPPDPSMVWGMENSIQNYVTANALYHANEEMRQRLEDCVAVVKSLQHELAASRVLSKNTQSRLDEATQQIQQLVRERDIACQKLSVAQNATAELERQQKQTSVEEERIRFSLESQVTELRNRLVVGADSNELLSRDVRTLLAEVQEKTTTIQGLRSKLSLAETALASQRHTNENLLAEFRSLNSQLVEERKRLLAMTQEVHLANMRAGDIRDAEARLAAVVNDRTALEREHARLMESLVTVTEGALAMARAEVKQDLDEFRGSAAHWEEVAQLLYKDIAQRTQAHIHCREECEEAKRARDEAAVALRVANDELRSHRLKLDIVWPTHRADTDGLTHEQMLSIFGRYNVGARRGSQMQQQQQSEQHRLSPAEPTLPDGKPQLYDDNVALYGRDFVTALQGAPLDEQVRELQEANSALVAELQRLQVTNELQKERLRSLESQLQRRQEAVETATAELKEREMAGQTFLQSQLDRVSFLEAQVRSLRGYSISPTKSLCEVEGNETVFELFVGQILSTETPAGVELRNTFPPVFCSIDFLLHETVTTPVVAGLNAFLDTSVSFCVAMDALLLCYLQTRQLLLQLHCVRSQEELGETMVDNDETGKLCIGERLYTTVAEGSVSLSALVADPKQLEADRPSIRGHVPLRDGFGHHIASVEFAVTVRTPFSEAFRALAAEGTRSWSLAKHEEQQQMVQDPVSTVLAASSSRSSPLVAVVQRDSPICEQVEGGSEVRSVRAVSTPRHERRMVLVPTPHRSNATGPISSTSSSNTLLERSSSFTLVPRAAAIAAASAPNTVQALVVDVCKLKLPHDLYPVPRLSCYYALEPLGCNLYLHAPPTARYEYEYLQEGGFNGKRFPIGSLRELLAVTREPFILFFFDESAVSTTIDMASAEGKVERHRGQYWATARTEWRLALEKPEEFVSLELPLINKQGLPIKGATVRVRLLATCKGEGPQGENPAQREPQSLLGVAARLPEHRTRGFEGAATAVEARVVGIATNLDVQGCECPEDSIDMEIMRHQLGSFIP
Protein: Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) (Q9BTT6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11440998}. Membrane {ECO:0000269|PubMed:11440998}; Peripheral membrane protein {ECO:0000269|PubMed:11440998}. Note=Localized at the basolateral side of epithelial cells.
Interaction partners:
- Disks large homolog 4
Sequence:
MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETRTLLRRATPHPGELKHMKKTVENLRNDMNAAKGLDSNKNEVNHAIDRVTTSV
Protein: Odontogenic ameloblast-associated protein (Apin) (Q3HS83)
Organism: Rattus norvegicus (Rat)
Function: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
Subcellular location: Secreted {ECO:0000269|PubMed:17451507}. Cytoplasm {ECO:0000250|UniProtKB:A1E959}. Nucleus {ECO:0000250|UniProtKB:A1E959}.
Interaction partners:
- Amelotin
- Enamelin
- Secretory calcium-binding phosphoprotein proline-glutamine-rich protein 1
- Kallikrein-4
- Ameloblastin
- Amelogenin, X isoform
Sequence:
MKIIILLGLIGATSSAPLITQRLLSASNSHELLLNLNNGQLLPLQFQSAFNSWIPPFPGLLQQQQQQAQVSGHPQFPLSTLESFAGLFPNQIPFSRQVGFAQGGQAGQPDFSQQQTPSQTQQASPMSYVVPVKVPQDQTQMFQYYPVYMLLPWEQPQQTVTSSPQQTGQQLYEEQIPFYNQFGFVPQQAEPGVPGGQQHLVLDSFVGTAPETPGMPAVEGPLYPQKEPIGFKQDNVGVSTPSTSPKPDTGNFFTSEINPTIAPLLPEQKVNADSLREP