wanglab/gogpt-training-data huggingface dataset:
Protein: Pof6 interactor protein 1 (O42998)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for endocytosis. Also involved in cytokinesis and cell division.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11859360, ECO:0000269|PubMed:16823372}. Cytoplasmic vesicle {ECO:0000269|PubMed:11859360}. Nucleus {ECO:0000269|PubMed:11859360, ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}. Note=Localizes to endocytotic vesicles. {ECO:0000269|PubMed:11859360}.
Interaction partners:
- F-box protein pof6
- AP-1 complex subunit gamma-1
- F-box/WD repeat-containing protein pof1
- AP-1 complex subunit mu-1
Sequence:
MSLASLPLEKLTKVADVDKRETIYIDLLNYEKQLRNLNKNTREDSLQTNLNPLLSLIKKYGNFIAYPTRKLLSNCIIALLKGLEGYHQHRVLLYFVDSIHEKKDYIEIINVLSVLTSCLEEYGNQINQQETFIRFFFKYSKTNLSYGVRSIALDGLSKCIETSIQSTNEDLIKEIWKCIKSNLNTSSTNVLLSALRCAYYILGSSRLRNSELEWFKSFLFKKSSIDNSLLHSSLGRCFSALASAQADKSIEAAANAVPSTPADDENNEEVENRSTTRRFDETESFRHALRILVENYHSKHAKYESSKAVLVFAVKHLFLMQRPSFVSLNYTTIVDIILLHQSHSTSKEWLSSLEQYHCTYLFRDVIGRRFLDQSSELQGIEILLKRVLEPYLKDQSKISEIAVKTAMASTADILSRSKGSATALYSQLLDTTLQILYLGKDSLKNEVAWLLRCLLSVMPSPLMPTLLALFNRLELEFKHLRSKPKEVSPKLNVGIFNNLTLSLMSIYVAAEENPLYVASSIFSKLFNFSLDLIKSSSKLDLLAAQAQIKTGWRLLSAYVSFGPSFTRMQLSQLLILWKNALSRVPSKIHSQNFMETNADMFNRFEALQCLLSFLEYNKILFTPDVRKRVIIFLNNCLKFYKAFSLTKRLEITMPIPASDYSHLELRSLLLARIFQCFFELSQLSGMSLDDQELLSTTVSTIAELSSLQGYDTADEIVQAKAFTSPRVIPGIGSRFYAQPEEEFQTTMDDILPCYICESSSDSLSVISRSNSAKLPYVPPSLTSLIDNAIQLFASMFCHQPPKVMESTLEIMVASVTNLKSGRDILRYKAVTANTLFSIYGFLSAFDNKKVTLPDKVVSLMIELLENLTAVNDPKLIPYISKSYAFLAYLYQSKPTSVLDTIIKRAAESGDPNCRAVLILAVGHILKKVGSGVPQTTLITAYQLLKVFNTDSNDLVRECSIRASSVSLGSIAKTIPSVLTAQTRILLSYMLLPECDIDVQLLKKRNSLFFPSTLFANYLDCLINELGPNLRSDSSTSHFAFDLAHQLLLLSRDTGDNIIHVYKCYQHLYLFTPLETNSDFFIRELCGNIIDLKQPKRREISIEVLYQILLQNHEFSESCYKRHFDRLIWQSLDTTPDNKLLKNILYIWLNDYKDSDIHSWVNILLFLVGIKNTSSSERSNEQDIQNNLDEDTVSLAYGTSENASNPLFQKNYRWQTQFYAATCLKTCISEVMAENKEPAKYLISRISDLVRAAFVLSTSDNFYLKQGGFELLDTIITDFSNVMDPDFDDVSLLDQFQAQISSAFSSAFVDDSSPEIVAMSLNIASNFIGTGLLKTESQAAKILNLLKEALESSLPERAGFEENRHFKYDSKYFLRIATLSAWASLLVHSANVSYLKEFLSSNIRRLSSHWIMALRGYSRLQFGPSLVKDFVADTSFTRVQSINPKILLNIYEKSWLNIAESLTILLSTDANLIYGILSGDELSLSEEDVFFQDNINYASNRYSFNFFLFSVCFQSLLIPSTLQGFRNPVFRIMRIMTEVLTEELCTKVLYDHNVFPEVVDLLVRLILTEDWETKASIVIFVKKLALANPAHNDLKFCETDSVTSMEPTVSESVEMLFQLVKILTLALTVRVPGLRSDPAESATNKKASEFVILCFNAFLDVSNIFPAIVRVDLFATAMHVYEVIMDDQQLLKNSKQELLAALRKLLSTMVEQNDHTCTTLIYTLFEHLLNIYKETINDSDKKEKNETAFMSMVLVLTLAAPILDSEQLVVHDFLEELFSSLKSSEEDFALRTRCVTSLMLVNSKHPSMSALCRFIIYKSVTMLQNGEVLKSGDYVTEFIPALLDMHVHIPEEKKKSFLSMSIPIAAHFSILVEHADARKRIGEKLLKIMAIQPDEAKAIIQQLSPRQKKCVEEILIQNVE
Protein: leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (B4DER1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
Protein: RNA helicase (EC 3.6.4.13) (Q6NWH7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPGYSDRDRGRDRGSYSSGPPRFGGSRNGPPPAKKFGNPGDRLRKKHWNLDELPKFEKNFYQENPDVARRSAQEVEHYRRSKEITVKGRDGPKPIVKFHEANFPKYVMDVITKQNWTDPTPIQAQGWPVALSGKDMVGIAQTGSGKTLSYLLPAIVHINHQPFLEHGDGPICLVLAPTRELAQQVQQVAAEYGKASRIKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKEYIQINVGALQLSANHNILQIVDVCNDGEKEDKLIRLLEEIMSEKENKTIIFVETKRRCDDLTRRMRRDGWPAMGIHGDKNQQERDWVLNEFKYGKAPILIATDVASRGLDVEDVKFVINFDYPNNSEDYIHRIGRTARSQKTGTAYTFFTPNNMKQAHDLVSVLREANQAINPKLIQMAEDRGGKSNWSFKGRTRWRV
Protein: Uncharacterized protein (Q385G1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYLTHFSVSCLSFVYCDKNNCGNNNTVTVYIENQLYLCRKPSLSAVGLAALMWSVIRKLQGVPLDDDSDTSAESRIERNQQSIMMHEMKPHPRPLDPDIFTRAYGLLEYEKTRTWMLSEEFNKRVQAIDHLIELYTQQRENAVRSLRYGFLELLLSTLHNDEEETMRCKAAEALAMLLMEPLAVDMLLAMDDEKFTLRELLATLSDPSHEVVILSLRLILPCRMAFNSYEAIARLVKYNFIERGIALLRHPEDRVVATACTALVTIFSVKEAFIPFIRLGGMSELTVALHRDDPFVISEAADVVTHAASYRMGKKAAVDCRTLVALMPHMLHQNLRVRTAVTGAVAQLTIYEPGKYQAVDEGLPPLLLALLMEEEERDVLVNVVKGIINVAEHPVGRKRLLGAKERLQSLSSVADDYQPLTSSICEALSQLERKC
Protein: Sensor histidine kinase PdtaS (EC 2.7.13.3) (c-di-GMP sensing sensor histidine kinase PdtaS) (P9WGL5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the two-component regulatory system PdtaR/PdtaS. This two-component system plays an essential role in mycobacterial adaptation to poor nutrient conditions. Nutrient deprivation results in increasing intracellular concentrations of cyclic diguanosine monophosphate (c-di-GMP), which binds to the PdtaS sensor and promotes its autophosphorylation, leading to the activation of the signaling cascade. The phosphate group is then transferred to PdtaR.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:34003742}.
Interaction partners:
- Transcriptional regulatory protein PdtaR
- Biotinylated protein TB7.3
- Transcriptional regulatory protein
- Probable transcriptional regulatory protein
- Transcriptional regulator WhiB1
- Possible conserved transmembrane protein
Sequence:
MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML
Protein: DAZ associated protein 1 (K7EQ02)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNNSGADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASRPHTLDGRNQKGPRSDNSKSNKIFVGGIPHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAVNMHFHDIMGKKVEVKRAEPRDSKSQAPGQPGASQWGSRVVPNAANGWAGQPPPTWQQGYGPQGMWVPAGQAIGGYGPPPAGRGAPPPPPPFTSYIVSTPPGGFPPPQGFPQGYGAPPQFSFGYGPPPPPPDQFAPPGVPPPPATPGAAPLAFPPPPSQAAPDMSKPPTAQPDFPYGQY
Protein: Peroxisomal membrane protein PEX13 (Peroxin-13) (Q5BD69)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Microbody
- Peroxisomal targeting signal receptor
- Peroxisomal membrane protein PEX14
- propanoyl-CoA C-acyltransferase
- Lipid transfer protein, putative
- propanoyl-CoA C-acyltransferase
- Uncharacterized protein
- Peroxisome assembly protein 12
- Epoxide hydrolase, putative
Sequence:
MASVSPPKPWERAGATAGTALSSPATTSTAMSSTSTTSAAPTAGTSTTSATAPPSLPSRPSTLSTVANQNASNYSPYGASRFGASPYGGYGGYGSYSSPYSRFGGMGSMYGGYGGYGGMYSGMGGYGGMYGGGMPGDPNDPNSLTNSFNQSTQATFQMIESIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGNLRNTLGSALGIFTLIRWFKTLIAKITGRPPPADATALTPAAFAAFMGGRATLPDGSPAPPRPSRKPFLMFLVALFGLPYLMGKLIKSLARSQEAQRQKIMMTANGEQQGVLDPSKLDFCRVLYDYTPESQETNGIDLAVKKGDIVAVLSKSDPMGNASEWWRCRARDGRVGYLPGPYLETIQRKPQQQALTSGSEAGSRSNTMQSQTQVGNEVAAGQKPELKGKMGDISAESFQKSAFYS
Protein: Protein PAT1 homolog 2 (PAT1-like protein 2) (Protein PAT1 homolog a) (Pat1a) (A2ARM1)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that acts as a translational repressor.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20826699}. Nucleus {ECO:0000269|PubMed:20826699}.
Interaction partners:
- 5'-3' exoribonuclease 1
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm4
- Probable ATP-dependent RNA helicase DDX6
- m7GpppN-mRNA hydrolase
- Enhancer of mRNA-decapping protein 3
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm2
- Protein LSM14 homolog B
- CCR4-NOT transcription complex subunit 3
Sequence:
MKCLEGLHLQQRPSKFSVSLAPEEGLVCAFQLEEEKENEDECVCSDQAPEVKEEGCGLGDPAIVSAFQNTQVPQQRGLHSSHRVKVSGALGMSSASLHFMWQSVFPRASSPAHHFGPQQPSPDPFLFYSPLTPWPPKLSLPSHLTQLHPQHQQILQQQQRWRRRRSPTARSVPAQKPWSREPAASDAYANLMTRKEKDWVIRVQMVQLQSENPRLDDYYYQKYYQKLEKRQADKELLGQKTRAESLKLVTPYIQKPEVYESVVRIEGSLGQVAVSTCFSPRRAIDAVSHGTQEQDTGAASSQRLRVLSQIEKMFLQLLKIEEGQNDGLPQLYHTREQSSQVEKLFQALKTQEQNNLEEAADNLLQVLSVRKGKVLVARLLPFLPPDQAVSLLLYITYHLPLLIQRDMADQGLHMLFKPLGKYISHLTFHQLLHAMQGLMLLSPGSSERPVSVVLQNQFGISLLYALLSHGEQLVSLDPSLRSSSDCATWTDLVILIAWEIAQLPAASLAEPLAFPRNLLPCSAITWTSN
Protein: Probable carboxylesterase Culp2 (EC 3.1.1.-) (CFP25) (Cutinase-like protein 2) (Culp2) (P9WP41)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Shows weak esterase activity with the p-nitrophenol-linked aliphatic ester pNP-butyrate. Does not exhibit cutinase activity.
Subcellular location: Secreted {ECO:0000269|PubMed:19225166, ECO:0000269|PubMed:9673225}. Cell surface {ECO:0000269|PubMed:21594640}.
Interaction partners:
- Carboxylesterase/lipase Culp6
- DUF4185 domain-containing protein
- Serine hydroxymethyltransferase 1
- Uncharacterized protein Rv1278
Sequence:
MNDLLTRRLLTMGAAAAMLAAVLLLTPITVPAGYPGAVAPATAACPDAEVVFARGRFEPPGIGTVGNAFVSALRSKVNKNVGVYAVKYPADNQIDVGANDMSAHIQSMANSCPNTRLVPGGYSLGAAVTDVVLAVPTQMWGFTNPLPPGSDEHIAAVALFGNGSQWVGPITNFSPAYNDRTIELCHGDDPVCHPADPNTWEANWPQHLAGAYVSSGMVNQAADFVAGKLQ
Protein: Solute carrier family 30 (Zinc transporter), member 1 (Solute carrier family 30 member 1a) (Zinc transporter 1a) (Q6P3M0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Zinc transporter ZIP10
- Zinc transporter ZIP1
- Zinc transporter 6
- Solute carrier family 39 member 8.
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter Slc39a7
- Metal cation symporter ZIP14
- Solute carrier family 39 member 6.
- Zinc transporter ZIP13
- Zinc transporter ZIP9
Sequence:
MACAPNRVRLLCMLSLTFGFFIVEVVVSRITSSLAMLSDSFHMLSDVIALVVALVAVRFAEQTQSTNKNTFGWIRAEVMGALVNAVFLTALCFTIILEAIERFTEPHEIEQPWVVIGVGALGLLVNLLGLCLFHGHAGGGGHGHSHGGHGHSHGGAKKHKNGKVRRSETLEDSRSAGEETNNLVANHNSPNGVNAERKAADMCHSDSLDLQINGSAPYDELENGHDAASQLNMRGVFLHVLGDALGSVIVVINAIIFVFVWKPCEPGTICENPCSGQHCADHALNISSPLTNGTLIKAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDMHQLNARLRDLEGVLAVHELHIWQLAGSRIIATAHIKCHDPTSYMDVAKRIKDFFHDEGIHATTIQPEFVTVNSESRASLCELSCRTQCAPKLCCGAVDTAKPLEGSLESKKSCESKTPTLPSASVTSLEIISESVEDTSRPESVVIITREVESSL
Protein: BBG-LP15 (Q15K25)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
KTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKICFA
Protein: Endothelin-1 (ET-1) (Preproendothelin-1) (PPET1) [Cleaved into: Big endothelin-1] (P22388)
Organism: Rattus norvegicus (Rat)
Function: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor.
Subcellular location: Secreted.
Interaction partners:
- Endothelin-1 receptor
- Endothelin receptor type B
- Endothelin-converting enzyme 1
- Matrix metalloproteinase-9
- 72 kDa type IV collagenase
- endothelin-converting enzyme 1
- Endothelin-3
- B1 bradykinin receptor
- B2 bradykinin receptor
- Endothelin-2
Sequence:
MDYFPVIFSLLFVAFQGAPETAVLGAELSPRAEKEVQSPPPSTSWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGSPSRSKRSLKDLLPTKTTDQGNRCQCAHQKDKKCWNFCQADKELRAQSTMQKGVKDFKKGKPCPKLGKKCIYQQLVEGRKLRRLEAISNSIKTSFRVAKLKAELYRDQKLIHNRAH
Protein: TLE family member 1, transcriptional corepressor (A0A669KAE5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAGLDFHLELVPGNGKFGLKEKSWILSRKSSFEIKSAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYAS
Protein: DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) (Q6P3S1)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20154091}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:20154091}.
Interaction partners:
- Ras-related protein Rab-35
- DENN domain-containing protein 1A
- 14-3-3 protein epsilon
- LIM/homeobox protein Lhx9
Sequence:
MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTPYSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSLFILKEENSNKHLGADNVSDPTSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLGRHSSTFVPWEKEGKEAKETSEDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT
Protein: Origin recognition complex subunit 2 (Q09142)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. Together with cdc18, plays a role in preventing DNA rereplication and resulting genetic instability upon cell cycle-regulated phosphorylation by cdc2.
Subcellular location: Nucleus {ECO:0000269|PubMed:15314153}. Chromosome {ECO:0000269|PubMed:15314153}.
Interaction partners:
- Origin recognition complex subunit 1
- DNA replication licensing factor mcm2
- Origin recognition complex subunit 6
- Cell division control protein 18
- Origin recognition complex subunit 3
- Origin recognition complex subunit 5
- Origin recognition complex subunit 4
- DNA replication licensing factor mcm3
- Cell division cycle protein cdt1
- DNA replication licensing factor mcm5
Sequence:
MLINEHVRERYHFLRVSLTRVAHLVFANSHESNDLKMVENVSSTPKKGVLEDPSTLTPEVVTPRTPGHRIIKAKGAYTKDRSAKRRRGRIEIERHLLGEFDDNVGSNSLLDVPLYSLEAEPLSPSVMLEDESMEGINQSPQGISVEKLGKEDNRSRSSTPASPSLESHEFSESREAGLSQSNGFEARSHGTGFDEYFDKFSQRKTSSNTLSQLPVLDNQVYLDTVKEICTETEQHTQTLVHFQSRNFHQWYFELVNNFNLLFYGFGSKEHFLSSFVEKKLPCFPIFVVKGYFPQLQLKNVLSSFLEFLEVTPAASVSDMLIQSLSIINSPSFSLGKIVFLVHNIDGESLIDERFQSALAAIASSKNVYFIASVDHVNFALLWDTSLESSFNFVMHDATTFARYYNETTYENSLGIGRANVSNKEKAIKHVLYSLPANSRGIFKFLLIHQLERMMDTQDFDARQGEKVGIEYRSFFQKCSAEFLCSNEPNFRSQLTEFFDHNIIESKRDVSNSEILWVPYPKNLLEILLEDMMEDV
Protein: Membrane associated ring-CH-type finger 1 (D6RGC4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004439}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004155}.
Interaction partners:
- Bone marrow stromal antigen 2
- Ubiquitin-conjugating enzyme E2 H
- Transferrin receptor protein 1
- T-lymphocyte activation antigen CD86
- HLA class II histocompatibility antigen, DP alpha 1 chain
- Ubiquitin-conjugating enzyme E2 D1
Sequence:
MLGWCEAIARNPHRIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRSAILHDMSEESFEYCTPVMVLSPARKESGKKSVIQRPRRRRKASERYEHAAEEQIRGRKNDFHLQISSPRWRELYTDSSDSSSTDESHWIQAKRRAQVKFRLSRRRRRNNNKPCENLAGSSTPNGIELVDLGSKGKEQQELIECESCSLNLHRGKHTRYQECNPSLTQGSSEIKRSSRNHEKSKGRYHHRDPQLLQSLRKNEIMKKTFSETDSSTEILGVPEGSKDMNDAGLQVNNPVQKPPATYDDGSDNLEVCRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV
Protein: Glucosylceramidase (EC 3.2.1.45) (B7Z6S9)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome membrane {ECO:0000256|ARBA:ARBA00004207}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004207}; Lumenal side {ECO:0000256|ARBA:ARBA00004207}.
Interaction partners:
Sequence:
MSDRLFSNPGPAPTPQGCFSRGCGWSGCILPSESYCAGPQSPVPPRRLCRLRWDFVLPPVGAAVSLRRRDSGTPVVFSSSNDPEGMEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFGLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Protein: Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65) (Testis development protein NYD-SP28) (Q8IXS2)
Organism: Homo sapiens (Human)
Function: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular location: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:A8JB22}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8JB22}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JB22}.
Interaction partners:
- Dynein regulatory complex protein 1
- Dynein regulatory complex subunit 4
- Dynein axonemal intermediate chain 1
- Coiled-coil domain-containing protein 40
- Coiled-coil domain-containing protein 39
- Dynein axonemal intermediate chain 2
- Dynein regulatory complex subunit 7
- Outer dynein arm-docking complex subunit 1
- Dynein axonemal assembly factor 19
- Radial spoke head protein 4 homolog A
Sequence:
MPKKEKMAKTPLSDEKQLLLFQQKLLAEEEMAKKKERLLSQFLKDKLAKEEHNSALNLNKINTQWRTVLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYAHALRSHLHNVDQLLALQRHRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDSEYESKLEFQSMWNDLKNMNLEEKHFLRLHLENRVEDLWRKFQDVLKNYTDATEDRKAAFETLQVKDEKSSKEIEVQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRNDKELVLVQLRKLKAQRTQARAASQKNLVRLTLESNATLKALRKIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEGIQKNNLEELTEELTKVMVDYIGMENFWKRYNKVKLEQLSLQHRRAQLLDINGKLREMLKQYLDGISVSDEVLSQLNPLFIVNYQSNLLQPLSIRIAHPGDKQHPTT
Protein: Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (Antiquitin-1) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) (P83402)
Organism: Acanthopagrus schlegelii (Black porgy)
Interaction partners:
Sequence:
SGLLINQPKYSWLKELGL
Protein: Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) (O15254)
Organism: Homo sapiens (Human)
Function: Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
Subcellular location: Peroxisome {ECO:0000305}.
Interaction partners:
- 3-ketoacyl-CoA thiolase, peroxisomal
- Peroxisomal bifunctional enzyme
- Enoyl-CoA hydratase, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
- Peroxisomal multifunctional enzyme type 2
- 3-ketoacyl-CoA thiolase, mitochondrial
- Sterol carrier protein 2
- Trifunctional enzyme subunit alpha, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL
Protein: Ras-related protein Rab-5B (EC 3.6.5.2) (P61021)
Organism: Mus musculus (Mouse)
Function: Protein transport (By similarity). Probably involved in vesicular traffic (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P61020}; Lipid-anchor {ECO:0000250|UniProtKB:P61020}; Cytoplasmic side {ECO:0000250|UniProtKB:P61020}. Early endosome membrane {ECO:0000305|PubMed:7789520}; Lipid-anchor {ECO:0000250|UniProtKB:P61020}. Melanosome {ECO:0000250|UniProtKB:P61020}.
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Early endosome antigen 1
- Ras and Rab interactor 1
- Ras-related protein Rab-5A
- Rab5 GDP/GTP exchange factor
- Leucine-rich repeat serine/threonine-protein kinase 2
- Rab GDP dissociation inhibitor alpha
- GTPase-activating protein and VPS9 domain-containing protein 1
- Rab GDP dissociation inhibitor beta
- Alsin
Sequence:
MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN
Protein: BCL-WEL (Q7TS60)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MSLFGLCQYFSYIYVSLSSLPLSAARMATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK