wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) (P26433)
Organism: Rattus norvegicus (Rat)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:20584908}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Recycling endosome membrane {ECO:0000269|PubMed:9442041}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Early endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Angiotensin-2 enhances apical expression (By similarity). Translocates between intracellular compartments and the plasma membrane via a clathrin-mediated pathway (PubMed:9442041). {ECO:0000250|UniProtKB:Q28362, ECO:0000269|PubMed:9442041}.
Interaction partners:
- Na
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Na
- Na
- Calcineurin B homologous protein 1
- Epithelial sodium channel subunit gamma
- Chloride anion exchanger
- Electrogenic sodium bicarbonate cotransporter 1
- Ezrin
- Cubilin
Sequence:
MWHPALGPGWKPLLALALALTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEEATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM
Protein: MOB kinase activator-like 2A (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) (F4K495)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:15469496}.
Interaction partners:
- Protein NLP2
- Rop guanine nucleotide exchange factor 14
- Protein NLP1
- Protein NLP3
- Protein NLP9
- Protein NLP4
- Protein NLP5
- Protein NLP8
Sequence:
MGGFLVLNSSNNVVRTVPSKKRKHPEYKSKIRELISGIRSDNLREAVRLPQGVDINEWFAMNTVDFFNQISLLYATLEEFCTQTTCPVMNAGRYEYRWADGTTITKPKTVSAPKYVEYLIDWVETEIDNEAIFPKNPGEPFPPNFEDFVKRILRKLFRVYAHIYYSHFHEIVALNEQAHLNTCFKHFLLFVSEFQLVDKEKEMAPIKSLVETMLDQ
Protein: tRNA (guanosine(18)-2'-O)-methyltransferase (EC 2.1.1.34) (tRNA [Gm18] methyltransferase) (O67577)
Organism: Aquifex aeolicus (strain VF5)
Function: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. Type II methylase, which methylates only a subset of tRNA species.
Interaction partners:
- Large ribosomal subunit protein uL13
- tRNA pseudouridine synthase D
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein bL21
- Ribosomal silencing factor RsfS
- Uncharacterized RNA pseudouridine synthase aq_1758
- Large ribosomal subunit protein bL17
- Large ribosomal subunit protein uL15
- Acyl carrier protein
- Large ribosomal subunit protein uL11
Sequence:
MVMEYLVLEKRLKRLREVLEKRQKDLIVFADNVKNEHNFSAIVRTCDAVGVLYLYYYHAEGKKAKINEGITQGSHKWVFIEKVDNPVQKLLEFKNRGFQIVATWLSKESVNFREVDYTKPTVLVVGNELQGVSPEIVEIADKKIVIPMYGMAQSLNVSVATGIILYEAQRQREEKGMYSRPSLSEEEIQKILKKWAYEDVIKERKRTLSTS
Protein: Neurabin I (Neural tissue-specific F-actin binding protein) (Protein phosphatase 1, regulatory subunit 9A) (Q7TN74)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sequence:
MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAIIAKTRGKGRPSSPQRRMKPKEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSVHESGQNHRYSPKKEKGGGTEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSEPPGALTSGKAESADYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSKPPSNKQDTDTEDAQKSDAVPVPEVAQKGTSLASLPSEESQLSTEAEDVTTAQPEALDSTDKDSPEEPSAENQAMPKSHILSPRNEPLEDAEANVVGSERAQHQKKDLTGGDLTSPDASASSCGREVPEDSNSFESSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENNYYQPDMEYSEIVGLPEEEEIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTDGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQYDADDDETGEYATDEEEDEGGPILPSGDVAIEVFELPENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEVERKKREEVEKAHLLEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPTRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHTQSQNRAVHEWSVQQVSHWLMSLSLDQYVPEFSAQSISGEQLLQLDGNKLKALGMTSSQDRALVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKSEKMTSTADQP
Protein: Galactose transporter (Galactose permease) (P13181)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GAL2 is a facilitated diffusion transporter required for both the high-affinity galactokinase-dependent and low-affinity galactokinase-independent galactose transport processes.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Bifunctional protein GAL10
- Galactose-1-phosphate uridylyltransferase
- Protein GAL3
- Galactokinase
- Galactose/lactose metabolism regulatory protein GAL80
- Regulatory protein GAL4
- Carbon catabolite-derepressing protein kinase
- Orotidine 5'-phosphate decarboxylase
- 3-isopropylmalate dehydrogenase
- Imidazoleglycerol-phosphate dehydratase
Sequence:
MAVEENNMPVVSQQPQAGEDVISSLSKDSHLSAQSQKYSNDELKAGESGSEGSQSVPIEIPKKPMSEYVTVSLLCLCVAFGGFMFGWDTGTISGFVVQTDFLRRFGMKHKDGTHYLSNVRTGLIVAIFNIGCAFGGIILSKGGDMYGRKKGLSIVVSVYIVGIIIQIASINKWYQYFIGRIISGLGVGGIAVLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYCTNYGTKSYSNSVQWRVPLGLCFAWSLFMIGALTLVPESPRYLCEVNKVEDAKRSIAKSNKVSPEDPAVQAELDLIMAGIEAEKLAGNASWGELFSTKTKVFQRLLMGVFVQMFQQLTGNNYFFYYGTVIFKSVGLDDSFETSIVIGVVNFASTFFSLWTVENLGHRKCLLLGAATMMACMVIYASVGVTRLYPHGKSQPSSKGAGNCMIVFTCFYIFCYATTWAPVAWVITAESFPLRVKSKCMALASASNWVWGFLIAFFTPFITSAINFYYGYVFMGCLVAMFFYVFFFVPETKGLSLEEIQELWEEGVLPWKSEGWIPSSRRGNNYDLEDLQHDDKPWYKAMLE
Protein: Hattifattener, isoform F (X2J6N9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPGRTTTALPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVEQPDDMRSHFSGMPGKVGKSRYSQAGSTHTLNNYCDTSDNWTDHDMDIYMARNPTTRNGLVPL
Protein: Autophagy-related protein 101 (Meiotically up-regulated gene protein 66) (O13978)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Autophagy factor required for autophagosome formation (By similarity). Has a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Preautophagosomal structure membrane {ECO:0000269|PubMed:23950735}; Peripheral membrane protein {ECO:0000269|PubMed:23950735}.
Interaction partners:
- Autophagy protein 13
- Serine/threonine-protein kinase atg1
- Phosphatidylinositol 3-kinase pik3
- Taz1-interacting factor 1
- Serine/threonine-protein kinase vps15
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Vacuolar protein sorting-associated protein atg6
- Autophagy-related protein 9
- Ubiquitin-like modifier-activating enzyme atg7
Sequence:
MTNTVTIELKIGYKYAAEVVKAVLGVILFHRQFSTVPARTIDVLDITVPTLVGAELNEQLATKAAEFIDTIRNEAGANGQMILLLYERSPKKSWFGKGNTIPWEQWILHTTILEEGDSYQESSLSLEAAVEQIVQAVNLRSLSYLPPVAMDSGNYPYEIVTPTSTEGWGSLLKRMIIENVSGGD
Protein: TrwB (Q04230)
Organism: Escherichia coli
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MHPDDQRKVSAGIVIVLPLIFWITAVQKTEVLGSPKLLALWELMKLTPQKPILLLSALGGLAVGVLFVWLLNSVGQGEFGGAPFKRFLRGTRIVSGGKLKRMTREKAKQVTVAGVPMPRDAEPRHLLVNGATGTGKSVLLRELAYTGLLRGDRMVIVDPNGDMLSKFGRDKDIILNPYDQRTKGWSFFNEIRNDYDWQRYALSVVPRGKTDEAEEWASYGRLLLRETAKKLALIGTPSMRELFHWTTIATFDDLRGFLEGTLAESLFAGSNEASKALTSARFVLSDKLPEHVTMPDGDFSIRSWLEDPNGGNLFITWREDMGPALRPLISAWVDVVCTSILSLPEEPKRRLWLFIDELASLEKLASLADALTKGRKAGLRVVAGLQSTSQLDDVYGVKEAQTLRASFRSLVVLGGSRTDPKTNEDMSLSLGEHEVERDRYSKNTGKHHSTGRALERVRERVVMPAEIANLPDLTAYVGFAGNRPIAKVPLEIKQFANRQPAFVEGTI
Protein: Odorant receptor 35a (Q9V3Q2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 42b
- Odorant receptor 22a
- Odorant receptor 42a
- Odorant receptor 67b
- Odorant receptor 47a
- Odorant receptor 30a
- Ionotropic receptor 75a
- Odorant receptor 82a
- Adenylate cyclase type 3
- Odorant receptor 45b
Sequence:
MVRYVPRFADGQKVKLAWPLAVFRLNHIFWPLDPSTGKWGRYLDKVLAVAMSLVFMQHNDAELRYLRFEASNRNLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFYANIYIDPRKEPEMFRKVDGKMIINRLVSAMYGAVISLYLIAPVFSIINQSKDFLYSMIFPFDSDPLYIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDLQLAIEKILVARDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFKAYTNPMANYIYAIWFGAKTVELLSLGQIGSDLAFTTDSLSTMYYLTHWEQILQYSTNPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQAGLKILQASFSYFTFLTSMQRRQMSN
Protein: Trp operon repressor (P0A881)
Organism: Escherichia coli (strain K12)
Function: This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
Subcellular location: Cytoplasm.
Interaction partners:
- Tryptophan-specific transport protein
- HTH-type transcriptional regulatory protein TyrR
- Arginine repressor
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
- HTH-type transcriptional repressor PurR
- Anthranilate synthase component 1
- Tryptophan synthase beta chain
- Tryptophan synthase alpha chain
- Tryptophan biosynthesis protein TrpCF
- Bifunctional protein TrpGD
Sequence:
MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
Protein: Uncharacterized protein (Q57XR9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYRYASSAAAAGSHRLLFPRHSATTFIHMSATKTTNSNGGIKCTSSECRECPRCNSMRSSRVATIVPLLSCAPSILRHSNCCYGSFSHHHHYGIIANKSCGDVIYGSNAVAFHMQRRGFRRELCEGPLDLKAGERSARKGPPVAHSLPVYKTAHKLNHSVRWKNANLITNVAGGKDYRLRETQGEGTFDESGMYRDWLYGDERRYANYIGVVLGVLSISLFLYTMRVMGAETWDIPTPVLAAQRKKRAAALPEGGEGKEENLGAGENNASGTAELQIGEDALAMLKKPAVVSKAALVTAK
Protein: Large ribosomal subunit protein uL10y (60S acidic ribosomal protein P0-2) (Q42112)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Interaction partners:
- Large ribosomal subunit protein uL24z
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL4z
- Small ribosomal subunit protein eS6y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein P1w
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein uL3z
- Large ribosomal subunit protein eL29z
Sequence:
MVKATKAEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNTAILNLLPLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAPHMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKFAVASVAAVSADAGGGAPAAAKVEEKEESDEEDYGGDFGLFDEE
Protein: Forkhead box protein K2 (Cellular transcription factor ILF-1) (Interleukin enhancer-binding factor 1) (Q3UCQ1)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate. Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins. In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:16376864, ECO:0000269|PubMed:25402684}. Cytoplasm {ECO:0000269|PubMed:25402684}.
Interaction partners:
- Putative Polycomb group protein ASXL2
- Polycomb group protein ASXL1
- Host cell factor 1
- Ubiquitin carboxyl-terminal hydrolase BAP1
- Lysine-specific histone demethylase 1B
- Transcriptional repressor protein YY1
Sequence:
MAAAAALSGAGAPPAGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGHSAAAPEPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSEKREKQEAPESPVKPVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLSLMADNSQPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLVEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGASQPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPPAIKPVTYTVATPVTTPTSQPPVVQTVHVVHQIPAVSVTSVAGLAPANTYTVAGQAVVTQAAVLAPPNPEPQENGDHREVRVKVEPVPAISPATLGAASRIIQTSQGTPVQTVTIVQQAPLGQHQLPIKTVTQNGAHVVPMPTAVHSQVNNAAASPLHMLATHASASASLPTKRQNGDQAEQPELKRVKAEDGESIVIALSVDAPPAAVREKAIQN
Protein: Non-functional pseudokinase ZRK15 (Q0WSK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEWWKKKSLRAIIKRERLVRGHERGGTLLEEIIKSCNGKANPIKIFSADQILEATDTFSESNRVSELFDEIPYDWYYSGKNNNHHHHHKLLLIKKWRYRFSEHNGGNFCRDIAISSIVSGHKNFMQLVGCCLESEHPVLVYRASKKPTSLDLKMVVSWRQRLKIAEEIATALAYLHTAFPRPFVYRILRLEDILLDDEDGVAKLCNFSYCVSIPQGETFVKLGNGCIGGDYDYMDDNYLINGIVSEKTDAFGFGIFMQKLLMGEERFHELCYDRSDLTTFENRRKFAKCIDEIVDSNMLEKIGDVTEEERCRMEAFIVLSERCIGLRGEVPKMVEVAKELKRFLRDSSSSCGETSL
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit D (Glu-ADT subunit D) (EC 6.3.5.-) (Q9V0T9)
Organism: Pyrococcus abyssi (strain GE5 / Orsay)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
Interaction partners:
- Glutamyl-tRNA
- Uncharacterized protein
- Archaeal Rqc2 homolog aRqcH
Sequence:
MRVDEFLKERNINVGDFVRITKEEDGEEVTYEGYIMPPYELSAGDTLVLKLENGYNIGIALEKIRRIEVLERAKVKPEVHFEALIEGKPGLPEVTIIGTGGTIASRIDYETGAVYPAFTAEELAKAVPEIFEVANVKPKLLFNIFSEDMKPKHWVKIAHEVAKALNSGDYGVVVAHGTDTMGYTAAALSFMLRNLGKPVVLVGAQRSSDRPSSDAAMNLICSVRMATSEVAEVMVVMHGETGDTYCLAHRGTKVRKMHTSRRDAFRSINDVPIAKIWPNGEIEFLRKDYRKRSDEEVEVDDKIEEKVALVKVYPGISSEIIDFLVDKGYKGIVIEGTGLGHTPNDIIPSIERAVEEGVAVCMTSQCIYGRVNLNVYSTGRKLLKAGVIPCEDMLPETAYVKLMWVLGHTQNLEEVRKMMLTNYAGEITPYTRFDTYLR
Protein: Amino acid transporter (Q9U9K1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
Interaction partners:
Sequence:
MGPPTSTELPPKTTECSDAPVELTGYRRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMDEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKELMALDAASVNYQDMPAGTPNGHGHGHHDGGLLEGQTELETSSKCVMTMTDSVVVDISAVMNNVNLQQEHCNRRV
Protein: CcsA (C5MRH0)
Organism: Oryza sativa (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLFATLEHILTHISFSTISIVITIHLITLLVRELGGLRDSSEKGMIATFFCITGFLVSRWASSGHFPLSNLYESLIFLSWALYILHMIPKIQNSKNDLSTITTPSTILTQGFATSGLLTEMHQSTILVPALQSQWLMMHVSMMLLSYATLLCGSLLSAALLMIRFRKNLDFFSKKKKNVLLKTFFFNEIEYFYAKRSALKSTFFPLFPNYYKYQLIERLDSWSYRVISLGFTLLT
Protein: E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING-type E3 ubiquitin transferase CHFR) (Q382W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
- MRH domain-containing protein
- Protein OS9-like domain-containing protein
- Katanin p60 ATPase-containing subunit A-like 2
- Derlin
- Derlin
- UBX domain-containing protein
Sequence:
MSGCDGTEGRFGRISSWEPSTPPDVVTDSVEDAFEEVAPSVNGPLIARLIPIRDGSTASLRVPMPILEIYRDSGTITMGRSRELPVECRVDVARVSTQHCELRVNAVTRQVTVRDISLNGTFVNGKRLEKGVDVELQSGDQISFVKSLPTGTTATSTPAQTSSSESANVSSGGGNGAEYVFQRVSSTQSVSQMVEELTCSVCKHLYHRPCSALPCMHVFCASCLSKWLACGNVTCMECRAELSEVRPTHKLQNCVEQLLKLNPGLCRSAEELAECGFNDDIPPEGRKLLKRTRRVRDDDGDDYSDTGSDLDDDDDDFGSEFNTSSGGDGVNATHVPQLYQGQTHGHAPATGSCKHCEAPSAVDGFRCPARGMHQSCARCRRLFPMRPLCTRPQRCHLCSTPYCNLYYKDEGGCPVGADGGLTIVSQYRAPQALPPNLFGGNKVEQNIVSSYLMVKHVVVEDVWGECLQKLSGREWVPDITCVNGPVTADSALCEGCMDILFAALLFHYRRCIPRAELPYSVTDRPNCWYGLNCRTQFHNMQHANKYNHACYQEKRKE
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (Q38AY0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- NLE domain-containing protein
- Pescadillo homolog
- Ribosomal protein L1p/L10e family
- RNA-binding protein, putative
- Nucleolar GTP-binding protein 1
- Nucleolar complex protein 2
- Ribosome assembly factor mrt4
- rRNA processing protein, putative
- 60S ribosome subunit biogenesis protein NIP7 homolog
Sequence:
MGVDDVGSAEEIPEKKRRRMRRHRPKRRISQATEADDETLTFVGEEGGEEQQEYPVDEEKAASMPDVEGETSGRRKRQREEEPGKLEQPETNGPPIKVSRDREKYPPVSDYRSLKLNPHIVTALENDFKFQELTGIQGRCIPAALAGRDLLAEAKTGSGKTLAFLIPIVEIITRVGFRQRSGTAAIIIGPTRELCLQIEGVLLKLLKHFNGSVTFLCCIGGISRKQEAFKLVSGMMVVMATPGRLLDHLKLTTDWLTKNLLVLAVDEADRVLDNGFEDDMREIVSLLPRQRQTFLFSATQTTRVEQLARVSFYRPPLFISMKRKEDKATVDTLEQGYVICPSQQRLLVLYHFVRRNLKKKVIVFFSSRNAVSFHCELFNYIDVPCVAFHGKQKQHQRSATYMQFCNAPSGVLFTTDVAARGLDIPQVDWIVQFDPPDDPVKYVHRVGRTARAGRTGNALMFLLPQEKLFLKYLHDDAHVSVSEYTFDLNKVKGNVAEQLEQLVSANYYLRSSARLAYEGYLLSYSSSQLKNVFDIHNLDLAAVAKGFALSEPPPLKLDLSQSAAHMSKKSRHEFRRMMESKDSQRRRLNETTLKKRRENISGEW
Protein: F-box protein SKIP17 (SKP1-interacting partner 17) (Q0WRC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- F-box/LRR-repeat protein At4g14103
- Capsid-like protein
- IAA-leucine resistant 2
- Plant UBX domain-containing protein 4
Sequence:
MDPPTQSHNSVRTVPGSNHSHTDLIISSFLSFPDSSPISISNSFDRVLDRALASASADESVQDRLVDRTLELASLLLDSTRRCFRKRASVHNSNSWSLPPELTIKVFSMLDTKSMMQAAVCCTMFNKCAMDRLCYSHIDLTTSARYADKGVVSTMINRAGKELRSLKLGRVVRTAGSDSAAPLLSGSCLSPLAYNHGFLGSRLRSLRLYNLRPIKYRSLCDALSVCPNITDLRIVGLYNLTEELFNSLTKKCRLIEHLFLETYGYPRTLESKAGSSLVEFVTNCPNLTSLTLIRFGLTDDWARNLAESCRKLKYLNLSRSPTIKGRFLRELGLSCKENLLKTLILRSCPKLQEKEVLEFCNSLLTGNFKSIRQIDVSSNSGLASSDRGKRCNKPNFPLERLKEERSDVTFVADFPSTSSGKRYGVCDEEELRLIEMMEAEDDEVDEEDDSDDDTDDVSDEDESENDDDMGMGFDVDYLL
Protein: Retinaldehyde dehydrogenase 3 (RALDH-3) (RalDH3) (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Aldehyde dehydrogenase family 1 member A3) (Aldh1a3) (Q9JHW9)
Organism: Mus musculus (Mouse)
Function: NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (By similarity). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11013254}.
Interaction partners:
- Cytochrome P450 26A1
- Cytochrome P450 26B1
- Cytochrome P450 26C1
- Retinol dehydrogenase 5
- Dehydrogenase/reductase SDR family member 9
- All-trans-retinol dehydrogenase [NAD
- Retinol dehydrogenase 12
- Retinol dehydrogenase 11
- Alcohol dehydrogenase 1
- Short-chain dehydrogenase/reductase 3
Sequence:
MATTNGAVENGQPDGKPPALPRPIRNLEVKFTKIFINNDWHESKSGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSRGQLLHQLADLVERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWADKIQGRTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLASLIKEVGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVREAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRSVEFAKKRPVGDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRGLFIKPTVFSDVTDNMRIAKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDKALKLAAALESGTVWINCYNAFYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLEEKNP