wanglab/gogpt-training-data huggingface dataset:
Protein: Mic1 domain-containing protein (Q95Y58)
Organism: Caenorhabditis elegans
Interaction partners:
- Vacuolar fusion protein CCZ1 homolog
Sequence:
MLELGASFIPFEPDRSSHDGNITRNFFDCSSQRICTMRNNGALGLTSKSLKNDKIMNVRTKDRGEPSTVKFSPDGRLCAMQRTPTTADVVFLEKTETSLCLELTVNTKSKEPLLAVEWVTNNQLLLVNNHSAELLYINEDKKSSKLLKATNVNAAWAIYYAPSQLLLIANGQSCSYLQPFVVTHSQFTRMKGFEVDFGGSISKENFLEKDAAIATIYGRVYVLVFKYSNRNATVLDLYELPFDAATGPSFKHSLILGFNGGCGIHVIDNLVVVHHQASQKSLIFDIRVSSPSKSHSPLVVTTIESHPQHQPPPALYTNFWFTFLPDIVIDSSGGVMYSIRLKNEHAQLEIADKQTMLEYLARRSNEKKLFVTTLLACLKARALSLRQIRKVFAMLTGVTGKSSASENSVENGSGSSQKPVLDCEKYASLAVTQQEMQSSVLIPLREEVSLPESYVANIMLQYLRSLFDAEITPEAYLIEMVVETLAEAGEMSKLQQIVTYRVINDSKPLAFLLLSYEARCSTLFQSGVDILARNKASDEIVEVMLEKKQIVDAFRFIDVRNLNDALIPKVVEAANQHCVRQTRYAIKEHLTEKKAKASLYKSIGDELYTAEEVKGASEEQATCALFEI
Protein: GTP-binding protein, putative (Q57Z18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal export protein NMD3
- Uncharacterized protein
- Aminopeptidase, putative
- Nucleolar GTP-binding protein 1
- Protein SDA1
- Eukaryotic translation initiation factor 6
- Pescadillo homolog
- rRNA processing protein, putative
- Ribosome biogenesis protein BOP1 homolog
- 60S ribosomal protein L24, putative
Sequence:
MQSLGRSIQRSKQAAKRSSRTKYRQMMEAERNAAMVREMEEQEHQRRKGAPLKSIWETNNLEEFLLIADAQEKGYEAARDLHLVVDGTPHVVTNDKVLPLSDDRVDWLKISELLTIPRRPQWSYDMTAQEVQSLEASAFFEWRRRLAKLEEKHKVVMTPYEKNLEVWRQLWRVTERADIVLMILDARNPLVFRCADFELSVRETMGKAGKPKEVVFLLNKSDLLTEEQRRVWADYFTERGEAFIFFSATPSDSKKKESVHCAGVDGESEHDGSEGVASDHMTGSAGIGAEREVTTLGNDEDEDLFSVDNEKDFSKLMRNKKEKRRHNKKSLRAPVVVANPYQLIHQRKVCKEQLILRKQQPQNLNRPPQPLTADEKARDDRVSKLSSLDPWAVLDPEQLLDRLAMWRKSCSITDTETPLMVGLVGYPNVGKSSTINAILGCKKVVVSATPGKTKHFQTLVIPNERRVALCDCPGLVFPSFASTRAQMVCDGILPIDTATDVEAAIAILCQRIPRQVLEQQFNVSLRAGDDRDESHSLMERLLNAVARRRGYLGAHDRPNRSRAGRDILKLYVDGVLLYVEPPPSYHPRVSDIAAYVSQYKGKEGVIVDKSKRDSNHSVTEADLDGASEGDGDEWEDASSCASDLDDYDAEAWEALDRAAADRALSDADSVGSRDLEGDNGVADMAVPKFYVRPKGACGTLTRQEALNAEANVKRILMGMKNAARRRRRTNHQLDPADDVFINAEGEVELIIDDDDGIVEIGGASPCGKGGSSPRAVQAVENTKKMSKRQMRRELKRSGAGPVNPTTRRQVVQGY
Protein: Inner membrane transporter YjeM (P39282)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YjeN
- Inner membrane protein YjeO
- Elongation factor P--
- Uncharacterized protein YjeI
- 3-oxo-tetronate 4-phosphate decarboxylase
- 2-oxo-tetronate isomerase
- Uncharacterized protein YjeJ
- L-threonate dehydrogenase
Sequence:
MPHTIKKMSLIGLILMIFTSVFGFANSPSAYYLMGYSAIPFYIFSALLFFIPFALMMAEMGAAYRKEEGGIYSWMNNSVGPRFAFIGTFMWFSSYIIWMVSTSAKVWVPFSTFLYGSDMTQHWRIAGLEPTQVVGLLAVAWMILVTVVASKGINKIARITAVGGIAVMCLNLVLLLVSITILLLNGGHFAQDINFLASPNPGYQSGLAMLSFVVFAIFAYGGIEAVGGLVDKTENPEKNFAKGIVFAAIVISIGYSLAIFLWGVSTNWQQVLSNGSVNLGNITYVLMKSLGMTLGNALHLSPEASLSLGVWFARITGLSMFLAYTGAFFTLCYSPLKAIIQGTPKALWPEPMTRLNAMGMPSIAMWMQCGLVTVFILLVSFGGGTASAFFNKLTLMANVSMTLPYLFLALAFPFFKARQDLDRPFVIFKTHLSAMIATVVVVLVVTFANVFTIIQPVVEAGDWDSTLWMIGGPVFFSLLAMAIYQNYCSRVAKNPQWAVE
Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (P19785)
Organism: Mus musculus (Mouse)
Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. {ECO:0000250}.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase Src
- Nuclear receptor corepressor 1
- Transcription factor Sp1
- Nuclear receptor coactivator 3
- Transcription factor Jun
- Nuclear receptor coactivator 1
- Nuclear receptor coactivator 2
- Protein c-Fos
- Breast cancer type 1 susceptibility protein homolog
- Caveolin-1
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
Protein: Condensin complex subunit 2 (A1L231)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSAFSTPTARQRQWSSPALGHKAALSTTSTPLLDNIQGNDDEQERRQRRRSRVIDLHGVNDSSINEAGTHSSAGTPAAVPKLSSAQISEHYSTCIKLSTENKITTKNAFGLHLIDYMADILKEKDSELNFKVAAGTLDASTKIYAVRVDAVHADAYRVLGGLGSETKPKESQDGDDETEAAEGSQGEQVAAKQTKKRPPKKTVEQNLSNINLSESEMKCEVDPMFQRMAASFDENSTAGVFLSVLFSEDSCCELRFPSHMTLLKSQLPPVQVSHQNVPASPFTGHLKTLEDRPICPSLEDFSFTRWTPEQTTNLNQLLEKMKQGEHAFDVNADIEPDEDDAPDFGDNFDADVDEGRPGDNEEFKEHKEACSKSPQNGRGVIPIGEVDIATMCLQLSDQPREYSYFSPRTMATWVGPGYWLFKPGHKQDQKPDKEPRKRAPKNPLIIDFKADINFHNYFKTTRAATTISKSALNTSNKKTTLPADFQYPPSNLSQLNLKPSNTLSAEGKKRLSGELSEDIGEYDYNNANDTANFCPGLQEGDSEDAEGFGGSDNSQTDRPTPFSLDTDDISTYGEDCLVPEPHKLNIIEINYARTAKKMDMKKLKTTMWGLLTESPEKTAKQVESEDTTEVPGEKSFSQSIRNLVQRLPSAMATNLSVPLAFVALLHLANEKNLELHKIDGMTDIIIKQGH
Protein: At4g23910 (Q9T0A6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
METGTPLIAETIALTEKKVAMALDDIIKLAKRKTNVNKGKKPRREKNKNQNFNGAARNNTSNVRHHMNSLSAVRQGAVGKRRSRFQGIQFPVTTNIARKASTAAPLDFRGRAFNGGRMTSANQSRLIAPPVQNISVQARVNAKRHEVDQKVEHRGGKRKTLDSRFASMKEQRMTINNYGVTVQVPRLPPWVRARRFSQ
Protein: GA-binding protein alpha chain (GABP subunit alpha) (Q00422)
Organism: Mus musculus (Mouse)
Function: Transcription factor capable of interacting with purine rich repeats (GA repeats).
Subcellular location: Nucleus.
Interaction partners:
- GA-binding protein subunit beta-1
- Histone-arginine methyltransferase METTL23
- Transcriptional repressor CTCF
Sequence:
MTKREAEELIEIEIDGTEKAECTEESIVEQTYTPAECVSQAIDINEPIGNLKKLLEPRLQCSLDAHEICLQDIQLDPDRSLFDQGVKTDGTVQLSVQVISYQGMEPKLNILEIVKTAETVEVVIDPDAHHAEAEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERLGIPYDPIHWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVPPATPTTIKVINSSAKAAKVQRSPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVIECEQKKLARMQLHGIAQPVTAVALAATSLQADKEI
Protein: Protein unc-119 homolog B (Unc-119 lipid-binding chaperone B homolog 2) (E7F2M1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like 2
- STRA6-like.
Sequence:
MDGEGVKEPHSEDEMEHELSSDDQAERDEDEAEDVEEEMADAQDRGGLRNVEDWNGFISGGPAAEEEALLDWKPGDPVTPQYVLRLPGYTDDYMCSPEDNIYNISFSRFKIRDLEGGCVILDLKRHCPTEIKDMIELDAGRFIQYHFSPAFLNLREIGAMLEFTVGGKAVNKFRLIEKHYFRDLLLKTFDFEIGFCIPHSRNTCEHIYCLPDLDPHTIEEMINHPFETRSDSFYFANNTLIMHHKAEYSFSQGLQNNQNQS
Protein: Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) (P54652)
Organism: Homo sapiens (Human)
Function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P17156}. Note=Colocalizes with SHCBP1L at spindle during the meiosis process. {ECO:0000250|UniProtKB:P17156}.
Interaction partners:
- DnaJ homolog subfamily B member 1
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated protein 1
- DnaJ homolog subfamily A member 1
- DnaJ homolog subfamily A member 2
- DnaJ homolog subfamily B member 6
- Toll-like receptor 2
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 9
- Heat shock protein 105 kDa
Sequence:
MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD
Protein: Retinoic acid receptor responder protein 2 (Chemerin) (Q5BK77)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Chemerin-like receptor 1
- Chemerin-like receptor 2
- C-C motif chemokine receptor like 2
- Melatonin-related receptor
Sequence:
MKCLLISLALWLGTADIHGTELELSETQRRGLQVALEEFHRHPPVQWAFQEIGVDSADDLFFSAGTFVRLEFKLQQTSCLKKDWKKPECTIKPNGRKRKCLACIKLDPKGKVLGRMVHCPILKQGPQQEPQESQCSKIAQAGEDSRIYFFPGQFAFSRALQSK
Protein: Nuclear hormone receptor unc-55 (Uncoordinated protein 55) (G5ECR9)
Organism: Caenorhabditis elegans
Function: Transcription factor. Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factors unc-3 or irx-1 in subsets of motor neurons. Probably acts by binding to specific promoter elements. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures which are inserted into the vulva of the hermaphrodite and anchor the male to the hermaphrodite. Required for spicule prodding which allows detection of the vulva location and for spicule insertion into the vulva.
Subcellular location: Nucleus {ECO:0000255, ECO:0000255|RuleBase:RU004334}.
Interaction partners:
- Putative iroquois-class homeodomain protein irx-1
- Homeobox protein unc-30
- Immunoglobulin domain-containing protein oig-1
- T-box protein 12
Sequence:
MQDGSSGAASLGNSSPDATDCVVCGDKSSGKHYGQFSCEGCKSFFKRSIRRSLSYTCRATKNCAIDVQHRNQCQYCRLTKCIRMGMRKEGRRSNETQTAVSAVQRGRLPVTMPSLFPPNMFLRSPFPFMSVPFNPLMTAQFTKPSIKESIFEFAAQTIFATVNWARTSMSNLVKGDQLILLRHSWTPIFIFALAQSNFALNLSTHLTAVTATAASTENGSSSLGSKSEDEEKSEEKPERVFDEPQFQGFQAKIDKIRDFHLDVVESSSLRAVLLFSCDEEALEEKGKIEEIVEKLKSAVDEYCKMNKRSERYHQICECLQLLKSTRNLPISRLFFSRLLGTTPLETILSDLLITPPPPTLPFFPQLPSRN
Protein: Barrier-to-autointegration factor (LAP2-binding protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed] (O54962)
Organism: Mus musculus (Mouse)
Function: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (By similarity). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (By similarity). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (By similarity). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (By similarity). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (By similarity). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (By similarity). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75531}. Chromosome {ECO:0000250|UniProtKB:O75531}. Nucleus envelope {ECO:0000250|UniProtKB:O75531}. Cytoplasm {ECO:0000250|UniProtKB:O75531}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus. May be included in HIV-1 virions via its interaction with viral GAG polyprotein. {ECO:0000250|UniProtKB:O75531}.
Interaction partners:
- Emerin
- Prelamin-A/C
- Inner nuclear membrane protein Man1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Lamin-B1
- Paired box protein Pax-6
- Serine/threonine-protein kinase VRK1
- Lamin-B2
- Lamina-associated polypeptide 2, isoforms alpha/zeta
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Sequence:
MTTSQKHRDFVAEPMGEKPVGSLAGIGDVLSKRLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL
Protein: Erythropoietin receptor (EPO-R) (Q07303)
Organism: Rattus norvegicus (Rat)
Function: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P14753}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Erythropoietin
- Tyrosine-protein kinase
- Tyrosine-protein kinase JAK3
- Growth factor receptor-bound protein 2
- Tyrosine-protein kinase
- Thrombopoietin
- Transferrin receptor protein 2
- Granulocyte-macrophage colony-stimulating factor
- Insulin receptor substrate 2
Sequence:
MDQLRVARWPRVSPLCLLLAGAAWASSPSLPDPKFESKAALLASRGSEELLCFTQRLEDLVCFWEEAANSGMGFNYSFSYQLEGESRKSCRLHQAPTVRGSMRFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRALRQKIWPGIPSPENEFEGLFTTHKGNFQLWLLQRDGCLWWSPSSPFPEDPPAHLEVLSERRWGVTQAGDAGAEDKGPLLEPVGSERAQDTYLVLDEWLLPRCPCSENLSGPGDSVDPATMDEGSETSSCPSDLASKPRPEGTSPSSFEYTILDPSSKLLCPRALPPELPPTPPHLKYLYLVVSDSGISTDYSSGGSQGVHGDSSDGPYSHPYENSLVPDTEPLRPSYVACS
Protein: LD29573p (RNA exonuclease 5, isoform A) (RNA exonuclease 5, isoform B (EC 3.1.13.-)) (Q9VRX7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Probable oligoribonuclease
- IP20073p
- FI18136p1
- PAN2-PAN3 deadenylation complex subunit PAN3
- Exosome complex component 10 homolog
- Probable ATP-dependent RNA helicase Dbp73D
Sequence:
MKEHMSTKQHERNEKKKKKLAALANLMELNDRDRLHEAELAKKRDAEVEVEEKSTAKAEDGDDGFIVVGSKRKPRNRRQNNELEADSQTAPGTSDPEEPVNKKIRNYDAGGDSLPLEIGSLSEDQYNQLSAELRRRKRELENVPALRLREMGQRASLETPQDARTPIFLTDIQNLLMCALIGQKSPCRPDRWCSVEKWLSLSHSVVVILEGLSLYHYLSNETQFEATNRIFSTKLEMILPPQEEGQKIIDEIAKIPLTNAQARRLIDEHGSLESAVELNKDPTLFVKTIFPIESSKSESDDMHEDDKFPRTKLLLSALQMVDEGYPIPLQGELHTRFQNFKFTKDLYAPVTNRSPMFGVDCEMCHTEAGCNELTRISIVNENYETVYETLVLPNNRITDYLTQYSGITAEIMEQVTKRLDVVQKEVSELLPPDAILVGQSLNSDLNAMKMMHPYVIDTSVCFNTSGVRRRKTKLKDLAKTFLQEIIQENIDGHDSIEDSRATLKLVKKKLANSIEFGDQILTQHKQLQELANASSGDTISNNLFAHVAKRDKRTAIVTVGELQPRLKEVIEKAGEAAPKDQSTSVHVHEVSTAKEAIRKVNEVALENALTIANLRVPEQDFILDSAQRSVAKLDKTIDRLWKSVAHNGLFLVIMGGSTECSKGVAKIAIKRLNGSNQTMES
Protein: Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) (P09436)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm.
Interaction partners:
- Glutamine--tRNA ligase
- Leucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Putative proline--tRNA ligase YHR020W
- Methionine--tRNA ligase, cytoplasmic
- Glutamate--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, mitochondrial
- Arginine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, mitochondrial
- Probable proline--tRNA ligase, mitochondrial
Sequence:
MSESNAHFSFPKEEEKVLSLWDEIDAFHTSLELTKDKPEFSFFDGPPFATGTPHYGHILASTIKDIVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLGITGKDDVFKYGLENYNNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKTMYPSFMESTWWAFKQLHEKGQVYRGFKVMPYSTGLTTPLSNFEAQQNYKDVNDPAVTIGFNVIGQEKTQLVAWTTTPWTLPSNLSLCVNADFEYVKIYDETRDRYFILLESLIKTLYKKPKNEKYKIVEKIKGSDLVGLKYEPLFPYFAEQFHETAFRVISDDYVTSDSGTGIVHNAPAFGEEDNAACLKNGVISEDSVLPNAIDDLGRFTKDVPDFEGVYVKDADKLIIKYLTNTGNLLLASQIRHSYPFCWRSDTPLLYRSVPAWFVRVKNIVPQMLDSVMKSHWVPNTIKEKRFANWIANARDWNVSRNRYWGTPIPLWVSDDFEEVVCVGSIKELEELTGVRNITDLHRDVIDKLTIPSKQGKGDLKRIEEVFDCWFESGSMPYASQHYPFENTEKFDERVPANFISEGLDQTRGWFYTLAVLGTHLFGSVPYKNVIVSGIVLAADGRKMSKSLKNYPDPSIVLNKYGADALRLYLINSPVLKAESLKFKEEGVKEVVSKVLLPWWNSFKFLDGQIALLKKMSNIDFQYDDSVKSDNVMDRWILASMQSLVQFIHEEMGQYKLYTVVPKLLNFIDELTNWYIRFNRRRLKGENGVEDCLKALNSLFDALFTFVRAMAPFTPFLSESIYLRLKEYIPEAVLAKYGKDGRSVHFLSYPVVKKEYFDEAIETAVSRMQSVIDLGRNIREKKTISLKTPLKTLVILHSDESYLKDVEALKNYIIEELNVRDVVITSDEAKYGVEYKAVADWPVLGKKLKKDAKKVKDALPSVTSEQVREYLESGKLEVAGIELVKGDLNAIRGLPESAVQAGQETRTDQDVLIIMDTNIYSELKSEGLARELVNRIQKLRKKCGLEATDDVLVEYELVKDTIDFEAIVKEHFDMLSKTCRSDIAKYDGSKTDPIGDEEQSINDTIFKLKVFKL
Protein: Ethylene-responsive transcription factor 12 (AtERF12) (Ethylene-responsive element-binding factor 12) (EREBP-12) (Q94ID6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Tapetum-specific protein A9
- Pectate lyase
Sequence:
MASTTCAREVHYRGVRKRPWGRYAAEIRDPWKKTRVWLGTFDTPEEAALAYDGAARFLRGIKAKTNFPSPLSLDLNHLPSAPSAATAAANNQPHQHQQLWFAAPPPVPPSSDHHHQHHRIFLRTGVLNDKTSDYSSTEAPLYFTSSPNTATSSPGYQVVGFPMMNSSPSPVTVRRGLAIDLNEPPPLWL
Protein: Suppressor of lurcher protein 1 (Q93212)
Organism: Caenorhabditis elegans
Function: Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1.
Subcellular location: Postsynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:14749834}. Note=Colocalizes with glr-1 at the cell surface. Enriched at postsynaptic membranes.
Interaction partners:
- Glutamate receptor 1
- CUB domain-containing protein
- STarGazin
- STarGazin
- CUB domain-containing protein
- Protein cornichon homolog 1
- Glutamate receptor 2
Sequence:
MCRRAEDLVLLLIPILFGYFSHASEHECKCVLFNVTSGNFHSPEFPAPLEGVPCLFYHFQAPPDHIIRLTFDVFQLPPRIGVCSSSIMLFDHSTDGLIEFGERADFEFCGKEISSGRQFFSKDQHFLLQISSGKESSRGFRGSFLAIPKKNFTSDAVEMAECSYRVEKQKAIIYSPDYPYYYPSKVNCTYHIPQRKGFQIVVNSIVMDIGRDAILQIFESVEGKFEKRLIEMVTSVQKSIYVSSTSSLLIYFSAGNNDVERAVGFVIELQYSNAVWSQSPETASECQLNINSENFKEGQLSSDKIGRFTSSSLPTKCQIVLQGYPNEKISVKFTHFNLYVPDNKNVTKRCTEVDNLSADVRVGSRLSRIDEWCGKRAPPNLMSSSNLLQLEYNTKSSKAIRESTNDDIGFRLDYKFHTDWNMGNMKAKVDKKKECRFSFNSSEHTNGKLWSANYPGLYPRNLYCEYIFHGRNDQVVHIHFEYFDIEGFNQCDETTQSDYILFSNYQTHDRTNRRFCGKTAPKGPILSESNYFRMIFSTNDIFDATGFYAHYQFITQEKSQISRVKLTISSSQTPFSSFFLVILLFTFRYIANIF
Protein: LD30988p (Q95TQ1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00004436}.
Interaction partners:
Sequence:
MSWLLGRNRQQPQPDQTAGFSEGGGAADPEGRTAGEKSGYSQLSRAERKAMEAYRFDSSALERAADAAKTLERSKHAREALELSKMQEATRQTEYNTKVKEYEAHIEQAKVEQKRIDHEERRKTLIEETKQQQQRAQYQDQLSRKRYEDQLLQQQRVQEENLRKQEESVQRQEAMRRQTIEHEIEMKEKNRLKLLEHELRAKARVDRENRDINLEKIRLKAQEHRTTVLEGIKTAGTVIGAGAEAMLTDWDKVLTAAGGLSLLALGVYTAKGATGVVSRYVEARIGKPTLVGETSRFAFLDALKNPLHYLKRLRAKPTDALQGVVLNPKLEERLRDIAIATKNTRINKGMYRNVLMHGPPGTGKTMFAKKLAEHSGMDFAIMTGGDVAPMGKEGVTAIHKVFDWSHTSRRGLLLFVDEADAFLRKRSSEKISEDLRAALNAFLYRTSEQNPKFMLVLASNTPEQFDYAINDRLDEMVEFTLPGLEERERLLRLYFDKYVLQPAAAGAK
Protein: Tricarboxylate transport protein A, mitochondrial (Citrate transport protein A) (Solute carrier family 25 member 1a) (Q6PGY3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate (By similarity). Required for proper neuromuscular junction formation.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZU2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Citrate synthase, mitochondrial
- Large ribosomal subunit protein mL40
- Transport and Golgi organization protein 2 homolog)
- D-2-hydroxyglutarate dehydrogenase, mitochondrial
- ATP-citrate synthase
- L-2-hydroxyglutarate dehydrogenase, mitochondrial
Sequence:
MSSLYKPFCVSEGPCKDAILRRGCAPLQHPAAPTRIPSPGGGSTRTFTPIPNIYPGQRTLAAAAIGGRKITHPWKAIFAGGIAGGIEICITFPTEYVKTQLQLDERANPPRYRGIGDCVKLTVQYHGLRGLYRGLSSLLYGSIPKSAVRFGTFEVLSNPMRDATGRLDNKASLLCGLGAGIAEAVLVVCPMETVKVKFIHDQCSLRPRYRGFFHGVREIIRDQGVRGTYQGLTATLLKQGSNQAIRFYVMNLLRNWYKGDDPARDMHPLVTAMFGATAGAASVFGNTPLDVVKTRMQGLEAHRYKSTMDCAFQILKNEGPLAFYKGTVPRLGRVCLDVAIVFVLYEEVVKLLNNVWRTD