wanglab/gogpt-training-data huggingface dataset:
Protein: CTD kinase subunit gamma (CTDK-I gamma subunit) (CTD kinase subunit 3) (Q9USJ8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. As part of the CTDK-I complex, involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing. Together with ctk2, required for ctk1/lsk1 CTD kinase activation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- CTD kinase subunit beta
- CTD kinase subunit alpha
- Cyclin pch1
- Transcription elongation factor spt5
- Cyclin mcs2
- Transcription elongation factor spt4
- Probable cyclin-dependent kinase 9
- Serine/threonine-protein kinase crk1
- RNA polymerase II transcription factor B subunit 3
- FACT complex subunit pob3
Sequence:
MDPFEGRMTFLQLLGKLNASQFSQIKPAQFAIKHLDLEEDLYSCIWEELESGSFNTRVNIMYFVDTLCEMCLKNGLTGGYLNMISRDICKLVQNVAPIGAAGAANAPEVRKVLQSLHEKKVIDDNQYKDAMATVEAHEQASKSGDTSTSGAISKNDILKRIEEDRERHKRMRENIWAISEPELEAEIAWNTTQGITESDLESLKDEYEKFNECLHATS
Protein: Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) (P08553)
Organism: Mus musculus (Mouse)
Function: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22723690}. Cell projection, axon {ECO:0000269|PubMed:22723690}.
Interaction partners:
- Neurofilament light polypeptide
- Neurofilament heavy polypeptide
- Kinesin heavy chain isoform 5C
- Kinesin heavy chain isoform 5A
- Kinesin light chain 1
- Kinesin-1 heavy chain
- Kinesin light chain 2
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 11
- Kinesin light chain 4
Sequence:
MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEAEEKEEEPEAEKSPVKSPEAKEEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEEGETEAEGEGEEAEAKEEKKIEGKVEEVAVKEEIKVEKPEKAKSPMPKSPVEEVKPKPEAKAGKGEQKEEEKVEEEKKEVTKESPKEEKVEKKEEKPKDVADKKKAESPVKEKAVEEVITISKSVKVSLEKDTKEEKPQPQEKVKEKAEEEGGSEEEGSDRSPQESKKEDIAINGEVEGKEEEEQETQEKGSGREEEKGVVTNGLDVSPAEEKKGEDSSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD
Protein: Cytochrome c oxidase subunit 4 (H3BNV9)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367145}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367145}.
Interaction partners:
Sequence:
MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYGHLGLCLSDPVIHSL
Protein: Perilipin (G5DC08)
Organism: Sus scrofa (Pig)
Subcellular location: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
Interaction partners:
Sequence:
MASVAVESQPSVVTRVANLPLVSSTYDLVSSAYISTKDQYPYLKSLCEMAEKGVKTITSVAMSGALPIIQKLEPQIAIANTYACKGLDRIEEKLPILNQPTNQVVANAKGAVTGAKDAMTTTVTGAKDCVASTITEVVDKTKEAVTGSVEKTKSVVNGSINTVLGSRMMQLVSSGVEKAFTKSELLVDQYLPLTEEELEKEAKKVEGFDMVQKPSYYIRLGSLSTKLRSRAYQQALTRVKEVKQKSQETISQLHSTVNLIEFARKNVHNANQKIQGTQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLVSSIQGLPQNIHDQANHLGVMAGDIYSVFHNASSFKEMSDGLLSSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQDAQSRGAENTTSPETQQPETKHIKPAPASSAWGSQSGDTSCTVATC
Protein: Stromal interaction molecule 1a (Q1LY88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Calcium release-activated calcium channel protein 1
- Calcium release-activated calcium channel protein 1
- ORAI calcium release-activated calcium modulator 2
- Transient receptor potential cation channel, subfamily C, member 1
- Calcium-transporting ATPase
Sequence:
MEFSGLVTFWIACICFLLQCRADKLNPVNTDPLPADNGVSELCRIDEPLCQDENAILSFEAIRSIHKQMDDDDNGNVDVLETDGFLREDLNYHDPKGKHNTFHGDDQFISVEDLWNAWKSSEVYNWTVDEVVKWLIDYVELTQYVEAIKKLNFSGTAMPRLAVKNNTLTQTVLKILDRSHVQKLQLKALDTVLFGAPMMNRHNHLKDFMLVVSIVIGMGGCWFAYIQNRHSKDHMKKMMKDLDSLQRAEQSLHDLQQKLQIAQEEHRSVEVEKVNLEQKLRDEINTAKQEAQRLKELREGTENELSRQKYAEEELEQVRMALKKAEKELESRSSWSPPEALQKWLQLTHEVEVQYYNIKKQNAERQLQVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILAAKQALGEVTAALRERLHRWQQIELLTGFTLVHNPGLPSLASALNLDPSFMGGRGTPQHFMSDDMDDMDEDIVPPGTLQSPSMMSLRQRHIDPQMALGSQRDLNRSDSDSSLCISQTGEQLRLSYSSKGFPVKPTSLLHGPHSRSEEGAQSHTHNGGNRVHDGGPSPDGVPDSPILMKKLYGIEKSASMSEIHGSQAAMSMSESSRSLSPNSTEPDTPSPTGLTGGKAGNRIPQISSKKSPLEEDSGSTGEDTDSAASRKKHTFKIFKKQKK
Protein: Rho GTPase activating protein 30 (A0A0A0MRJ8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
Protein: E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) (Q9C026)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q91ZY8}. Synapse {ECO:0000250|UniProtKB:Q91ZY8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZY8}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). {ECO:0000250|UniProtKB:Q91ZY8, ECO:0000269|PubMed:20085810}.
Interaction partners:
- F-box/WD repeat-containing protein 1A
- Netrin receptor DCC
- Synaptosomal-associated protein 25
- Gamma-butyrobetaine dioxygenase
- T-cell receptor-associated transmembrane adapter 1
- Vasodilator-stimulated phosphoprotein
- E3 ubiquitin-protein ligase TRIM17
- Ubiquitin-conjugating enzyme E2 G2
Sequence:
MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA
Protein: Asp-hemolysin (Asp-HS) (Q00050)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
Sequence:
MASVQAYAQWVTVHLINSMSSETLSIQNASLSWGKWYKDGDKDAEITSEDVQQKTAPPGGSVNVNSCGRSDASSGTTGGFDLYDGNTKIGRVHWDCPWGSKTNDFDVGERNKNYWVEIGTWNKYGGAIGTVDVEVGRKR
Protein: Pre-mRNA-splicing factor CEF1, putative (Q7KQL1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Pre-mRNA-splicing factor SYF1, putative
- Pre-mRNA-splicing factor CLF1, putative
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor PRP46, putative
- Pre-mRNA-splicing factor CWF7, putative
- Pre-mRNA-splicing factor ISY1, putative
- Pre-mRNA-splicing factor RBM22 homolog
- Pre-mRNA-processing protein 45, putative
- U5 small nuclear ribonucleoprotein component, putative
- Pre-mRNA-processing factor 17
Sequence:
MRIQIKGGIWKNCEDEVLKAAVMKYGLNNWSRVASLLVRKSAKQCKARWYEWLDPSVRKTEWNKEEEEKLLHLAKLFPTQWRTIAPIVGRTAQQCLEHYEYLLDEAEGKVYDKNKNPRHLRPGEIDPAPESKPARADPVDMDEDEKEMLAEAKARLANTKGKKAKRKAREKQLEQARRLALLQKKRELKAAGITSLNYKRKDKNKIDHSKEILFHRKPLKGFYDVKDEQNINDDIYENNKTNQKKSIKSMDVENINDAMEYNKNKGKRQHQHNNNEEANLLSTIENYDKQFNELSHLRKRVRLNLPEPILNENEIDEIIQINKEASAFNDIIKDQNDKLPINNILPSIESSSFILNNKDKFSNLETDFYNNNNNKSIAFSSKLDLSIQQAAKNIISRKMNIPFIGMNNDYNEEEFERKNNIFQKSNKNVPDDLEYDDTNNYHNNNNNNNNNTSFNSIKNSTTLYNHLDVEKNIKDVQEEIEKQKKLNEEDQQKNQKEKLTIKNKIISDIKSFKKNISLYAHSIISYKNLKNDQSMMDNQTIQTTEYYDDNYEEKIDRAKLHIKASLANLPQETNLIELQLNEEHPECDTDNIEKDEIEKDIQDIENEKRKNEERKEKEKFNKQNKIIRWNLPRPYFLDKINLFNNYMHNEYEDVHNLIQREMLLLIKNDMFNYPLRNSTPVQNKVHVEDLENVYMNMAMKSINEEFEDMYGEASLNNNTKDDSNIDGCDEKSDNIDGCDEKSDTTNKGDDTSQCSIEHSSYNHIDVWEEINKNIIFCPSKNAYRFIEDVNENDKKENYKYKCEKLKNLILNDMEHYKKLENKYDIYTKGYQLKIKSYKKSYDTLFNSYINCINEKEALNVLHENEKIYALTRIKEEKKENKKEIEYHKSLQKFYQDLLETNHQLKETCKQTLKVP
Protein: Nuclear factor 1 (A0A1B0GU97)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQAETSN
Protein: GH05829p (Q8MSJ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|ARBA:ARBA00004430}.
Interaction partners:
Sequence:
MATKPGKGDGKQVKGKRTSKNKTDGPGGGGGDADDFDAWMKSRQLLKPDDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQIEESDEIGYPLPMPNYTVVEQRETDNVDGEEGEGEEDDDGATAKDAAVEDEDVEEEDDEEAKGTEGDEGEGEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNYCERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFREGEGNLLPLWKFQYDKTKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLYVSRGVNCKHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFSSKYLMTYYAHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRLSFNEKLAFIVVGDEKGVTTSLKLSPNLRMMVKPPKKQLYLDQNTLQIGKLEKLLSLVRELPEGSTAVPDAATTVRS
Protein: 7-hydroxymethyl chlorophyll a reductase, chloroplastic (EC 1.17.7.2) (Q8GS60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable iron-sulfur flavoprotein that converts 7-hydroxymethyl chlorophyll a to chlorophyll a using ferredoxin as a reducing equivalent. Catalyzes the reduction of a hydroxymethyl group to a methyl group. Belongs to the chlorophyll catabolic enzymes (CCEs).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21934147, ECO:0000269|PubMed:23200839}.
Interaction partners:
- Chlorophyll
- Probable chlorophyll
- Chlorophyll synthase, chloroplastic
- Magnesium dechelatase SGRL, chloroplastic
- Chlorophyllase-1
- Chlorophyllase-2
- Magnesium dechelatase SGR1, chloroplastic
- Red chlorophyll catabolite reductase, chloroplastic
- Magnesium dechelatase SGR2, chloroplastic
- Pheophorbide a oxygenase, chloroplastic
Sequence:
MITVVTSRLSLLPPVFSVVNSSSSRSKDMNLEPKKKVKLREDWREKSRPIPPGGTYPAKDHCSQCGLCDTYYIAHVKEACAFLGDGMSRIESLEPVVHGRGRKADSLQDTYFGVHQEQLYARKLKPVEGAQWTGIVTTIAIEMLKSNMVEAVVCVQSDPEDRLSPRPVLARTPEEVLAARGVKPTLSPNLNTLELIEASGVKRLLFCGVGCQVQALRSVEQHLNLEKLYVLGTNCVDNGTRDGLDKFLKAASKEPETVLHYEFMQDYKVQLKHLDGHIEEVPYFSLPANDLVDVIAPSCYSCFDYTNALADLVIGYMGVPKYSGLNMTDHPQYITVRNERGKEMLSLVENLLEITPTISSGDRRPFVTETVKADDAAKFGQGPAQPAPLFVGNIIAFILNLVGPKGLEFARYSLDYHTIRNYLYVNRKWGKQRANTHMPSYAKKIVEMYNKNGQIDKMLSKK
Protein: Interferon regulatory factor (A8QKA6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038196}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- E3 ubiquitin-protein ligase Mdm2-like
- Interferon regulatory factor
- Signal transducer and activator of transcription
- Interferon regulatory factor
- Interferon regulatory factor
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription 1
- Myeloid differentiation primary response protein MyD88
- Tyrosine-protein kinase
Sequence:
MPVSRMRMRPWLEEKIESNSISGLVWVDKDNKIFSVPWKHAARHGWDLNKDACLFKQWAMHTGKFIQGETKTDPKTWKANFRCAMNSLPDIEEVKDKSINRGSGAVRVYKMKNIYSKPNNKRSKANNVKKNKKGSQIKTGGMAYSETNCPENLNTNTHLQEDSMTQESIVDSTGNLGDFTFAPECSTNVEIGPDSTNNFYASFQVSPDHSTDYEDGHQETLIGMTHHWEQGSVNDKGFQSNEVGTAESFDTAESYHSQESQWSDNSETEIELRLYTELSSGLPIIDDILSYTDYWTLNNNTSSYPQQITCPL
Protein: Sarcosine oxidase subunit beta (EC 1.5.3.24) (Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit beta) (Tetrameric sarcosine oxidase subunit beta) (Q9HTE8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Sarcosine oxidase gamma subunit
- Sarcosine oxidase delta subunit
- Sarcosine oxidase alpha subunit
- Serine hydroxymethyltransferase 1
- DgcA, Dimethylglycine catabolism
- Glycine betaine monooxygenase oxygenase subunit
- 4-vinyl reductase 4VR domain-containing protein
- Membrane dipeptidase
- Low specificity L-threonine aldolase
- Glycine betaine monooxygenase reductase subunit
Sequence:
MQRYSGFGLLKHSLSHHENWQRMWRTPTPKPVYDVVIVGGGGHGLATAYYLAKEHGISNVAVVEKGWLGGGNTARNTTIVRSNYLWDESALLYEHAMKLWEGLSQDLNYNVMFSQRGVYNLCHTLQDMRDGERRVSANRLNGVDGELLNAQQVAEEIPYLDCSKSTRYPIMGATIQRRGGVARHDAVAWGFARAADALGVDLIQQTEVTGFRKQDGAVIGVETNRGFIGARRVGVVTAGNSGHMARLAGFRLPLESHPLQALVSEPLKPIIDSVIMSNAVHGYISQSDKGDLVIGAGIDGYNGYGQRGSYPVIEHTLQAIVEMFPVLSRVRMNRQWGGIVDTTPDACPIIGKTPVQNLFFNCGWGTGGFKATPGSGNVFAATLAKGEPHPLAAPFSIERFHSGALIDEHGAAAVAH
Protein: Inner nuclear membrane protein SRC1 (Helix-extension-helix domain-containing protein 1) (Q03707)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in sister chromatid separation.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:16929305}; Multi-pass membrane protein {ECO:0000269|PubMed:16929305}. Note=Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle.
Interaction partners:
- Monopolin complex subunit LRS4
- Nuclear rim protein 1
- Uncharacterized protein YJL049W
- Importin subunit alpha
- Monopolin complex subunit CSM1
- Nucleoporin POM152
- Spindle pole body assembly component MPS3
- Vacuolar-sorting protein SNF7
- Nuclear membrane organization protein APQ12
- Nucleoporin NUP60
Sequence:
MNSDLEYLEDGFDPNSMKVATLRRILVENNVDFPSNARKNALVGLFDEKVKPQIPQLRKMYLNVRPSDEGIVKMDRPSSSPSIASPRRSRRARREKSASPMAKQFKKNRILDDVSNDDDDDDDDDDDNDKKDDPLIVPSGTDTDEVDDEEDDVITSSSNKSDTNDFQQNSDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKRKTSDLNQEHGNGSAILGKLSVKTPIKNTNRKPVSMDNFNDSLTSSGTENDPFVPNIRHNPKELGTANGTGHSTPLSKLKVSASFADKLPQKEVPSTILVPEVEQQEPSQSERTPSLFSSEGSGSESEAPLLPEITTPGPHQPMGNTSNNVVEMIDTDSSNLVSDEDEVLVPTRIETPQLPTEKDVEKCEARVQELQEEVNEQLEHENGSEFDVKQGSGKVGNRHKFKRALKFLSKSLLALFLFCIFIVIPLLFGLWYREQRLLIGYCGHEVPSHRVSGNSFEFIQKLDNLLQDYRPKCIPCPPNGICYPYLKLKCKPDYKLAPSRLDFLEIIPAQGKCVKDDKKQQLVSEVVEKSLEFLRAKNAQISCGDGKDDIESGMTEDALYQIFNEARAPWIRDDEFEDLWIQVIKDLTEEPEILWRQLSPTDNNIGGNSNNIIKTNDVPRQKRHLPEKFISKTRNFRSTSKKYIGMKCRFEREIYQTYKKFQRPIWLMFLLIVISKVIEIKLKNYYRKKARIEELVTQTMEKLKFQKIKSMSDPKENAYLSIVQLRDIFLSDIVDLKYKNQLWSEVVKYLEHNNSNIKSNLTEIRGEIMKCWEWIGPMELNEPKDSAENKI
Protein: Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) (Q8VD75)
Organism: Mus musculus (Mouse)
Function: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription (By similarity). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (By similarity). Binds 3-phosphoinositides (via ENTH domain) (By similarity). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (By similarity). May play a functional role in the cell filament networks (By similarity). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endomembrane system {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR (By similarity). {ECO:0000250}.
Interaction partners:
- Huntingtin
- Intraflagellar transport protein 57 homolog
- Clathrin heavy chain 1
- Clathrin light chain B
- Caspase-3
- AP-2 complex subunit alpha-1
- Cyclin-G-associated kinase
- AP-2 complex subunit beta
- AP-2 complex subunit alpha-2
- AP-2 complex subunit sigma
Sequence:
MDRMASSMKQVSNPLPKVLSRRGVGAGMEAAERESFERTQTVSVNKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDASQQTLFDNKFDDVFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDNMKIESQRAMLQLKGRVSELEAELAEQQHLGRQAMDDCEFLRTELDELKRQREDTEKAQRSLTEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLEREKKELADSFARTQEQQDVLENLKHELATSRQELQVLHSNLETSAQSEAKWLTQIAELEKEQGSLATVAAQREEELSALRDQLESTQIKLAGAQESMCQQVKDQRKTLLAGIRKAAEREIQEALSQLEEPTLISCAGSTDHLLSKVSSVSSCLEQLEKNGSQYLACPEDISELLHSITLLAHLTGDTIIQGSATSLRAPPEPADSLTEACRQYGRETLAYLSSLEEEGTMENADVTALRNCLSRVKTLGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATTRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVASKDLQKEIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSREIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGTEASPSTVQEAIPDKE
Protein: Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) (Q92604)
Organism: Homo sapiens (Human)
Function: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor. Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors. Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15485873}; Multi-pass membrane protein {ECO:0000269|PubMed:15485873}.
Interaction partners:
- Cardiolipin synthase
- Lysophosphatidylcholine acyltransferase 1
- Lysophosphatidylcholine acyltransferase 2
- Lysophospholipid acyltransferase LPCAT4
- Lysocardiolipin acyltransferase 1
- Glycerol-3-phosphate acyltransferase 1, mitochondrial
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
- Potassium voltage-gated channel subfamily H member 1
- Voltage-gated delayed rectifier potassium channel KCNH1
Sequence:
MAITLEEAPWLGWLLVKALMRFAFMVVNNLVAIPSYICYVIILQPLRVLDSKRFWYIEGIMYKWLLGMVASWGWYAGYTVMEWGEDIKAVSKDEAVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWLMDHIFKYTNFGIVSLVHGDFFIRQGRSYRDQQLLLLKKHLENNYRSRDRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALVAQQKNGSPAGGDAKELDSKSKGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAVSREMTLSNLWIFLIQSFAFLSGYMWYNIIQYFYHCLF
Protein: Transcription elongation factor SPT5 (A0A1W2Q689)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036945}.
Interaction partners:
Sequence:
MSDSEDSNFSEEEDSERSSEAEEAEVEEDRRSAAGSEKEEEPEEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKVLSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPRTVGVIVRLERETFQVLNMHGKVVTVRHQAVTQKKDNRFAVALDSDQNNIHVKDIVKVIDGPHSGREGEIRHLYRSFAFLHCKKLVENGGMFVCKARHLVLAGGSKPRDVTNLTVGGFTPMSPRISSPMHPSAEGQHGGFGSPGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVDSQRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQIVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIIRMDLEDQQIKILNLRFLGKLLEA
Protein: Phosphotransferase (EC 2.7.1.-) (Q9GNE3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLDAEVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTSNRRVIVGMDGSVYRYHPEFDAYMRQTLQKLVKEDKEWDIMLSEDGSGRGAALVAAVASKTK