wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10) (O15205)
Organism: Homo sapiens (Human)
Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
Subcellular location: Nucleus {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:19033385}. Cytoplasm {ECO:0000250|UniProtKB:P63072}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme 6
- NEDD8 ultimate buster 1
- 26S proteasome non-ATPase regulatory subunit 4
- Ubiquitin-like protein NEDD8
- C-X-C motif chemokine 9
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-conjugating enzyme E2 R2
- Ubiquitin-conjugating enzyme E2 Z
- Proteasome subunit beta type-8
- Proteasome subunit beta type-9
Sequence:
MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVPVQDQVLLLGSKILKPRRSLSSYGIDKEKTIHLTLKVVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAMIETKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLFLACYCIGG
Protein: Replication factor C subunit 3 (Replication factor C3) (Activator 1 40 kDa subunit) (P38629)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair. RFC3 supplies a catalytic site to the ATP site of RFC4.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Checkpoint protein RAD24
- Telomere length regulation protein ELG1
- Replication factor C subunit 5
- Replication factor C subunit 1
- Replication factor C subunit 4
- Chromosome transmission fidelity protein 18
- Proliferating cell nuclear antigen
- Replication factor C subunit 2
- Chromosome transmission fidelity protein 8
- Sister chromatid cohesion protein DCC1
Sequence:
MSTSTEKRSKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEGKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFSKGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRVLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLADIEYSISKGGNDQIQGSAVIGAIKASFENETVKANV
Protein: Biotin carboxylase (EC 6.3.4.14) (Acetyl-coenzyme A carboxylase biotin carboxylase subunit A) (F4JYE0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDASMITNSKSITSPPSLALGKSGGGGVIRSSLCNLMMPSKVNFPRQRTQTLKVSQKKLKRATSGGLGVTCSGGDKILVANRGEIAVRVIRTAHEMGIPCVAVYSTIDKDALHVKLADEAVCIGEAPSNQSYLVIPNVLSAAISRGCTMLHPGYGFLSENALFVEMCRDHGINFIGPNPDSIRVMGDKATARETMKNAGVPTVPGSDGLLQSTEEAVRVANEIGFPVMIKATAGGGGRGMRLAKEPGEFVKLLQQAKSEAAAAFGNDGCYLEKFVQNPRHIEFQVLADKFGNVVHFGERDCSIQRRNQKLLEEAPSPALTAELRKAMGDAAVAAAASIGYIGVGTVEFLLDERGSFYFMEMNTRIQVEHPVTEMIYSVDLIEEQIRVAMGEKLRYKQEDIVLRGHSIECRINAEDPFKGFRPGPGRITSYLPSGGPFVRMDSHVYSDYVVPPSYDSLLGKLIVWAPTREKAIERMKRALNDTIITGVPTTINYHKLILDVEDFKNGKVDTAFIVKHEEELAEWDMKPLVKLNIEIGELHEKNETIYRGRQIKLCL
Protein: Ferritin-like protein (Flp) (Encapsulin-associated ferritin-like protein) (Q9WZP3)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like protein that probably stores iron in the encapsulin nanocompartment.
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:19172747, ECO:0000269|PubMed:27224728, ECO:0000269|PubMed:30376298, ECO:0000269|PubMed:32961724, ECO:0000269|PubMed:34815415}.
Interaction partners:
Sequence:
MADQYHEPVSELTGKDRDFVRALNSLKEEIEAVAWYHQRVVTTKDETVRKILEHNRDEEMEHAAMLLEWLRRNMPGWDEALRTYLFTDKPITEIEEETSGGSENTGGDLGIRKL
Protein: Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) (Q9UQ80)
Organism: Homo sapiens (Human)
Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Translocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}.
Interaction partners:
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL23
- 60S ribosomal export protein NMD3
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL10
Sequence:
MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENEAGD
Protein: Dihydrofolate synthetase (EC 6.3.2.12) (A0A1D8PQV5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Folic acid synthesis protein fol1
- Dihydrofolate reductase
- Folylpolyglutamate synthase
- aminodeoxychorismate synthase
- Thymidylate synthase
- Tryptophan synthase
- Multifunctional tryptophan biosynthesis protein
Sequence:
MPINLGLQRIAKLLGHLNNPQNAYKSIHIAGTNGKGSTLAYISSVLTEAKIKNGKFTSPHIINYHDCISINNQTYPKSKFDRINQQVIKINNDLNLECTEFEILTATAFKIFALEEIEMALVEVGVGGRLDATNVLIPYGETIGTSKGGVVATAITKIGLDHEKLLGGTLLAIAKEKSGIIKYGIPCFVDSSNDSIVLQAIREKSREVSCPLSVVEPIQANDDNQFIKYSPLKGSYQANNLSLAVEILKSLPYRISEEILINGISKTNWPGRLQTIQHKSLGSILLDGAHNESAAIELGKYLNTKYRKQEPEANMSEGNHTPIILVIGMTKGKAIGNLLKHVMSENDIVIPTMFTQPENMPWINSESISTLTSIAKDYCRDVRNIGDDAHIHQVFQYLKNNKNDKSLENKPIVVCGSLYLCGDVLREIAN
Protein: SNARE associated Golgi protein family (Q9SZ65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTYHEEDDTVSEFRVRVEEDGVDKLGHYVKLTEDFEVHRQETEQESSSSPSSSSSCGQKRSVWFWIKLGLFFTFLTALGLAGYKWLYPLIMDKELIPLIKWEMETFTHPVCGILVFASVSLFPVILIPTTPSMWVAGITFGYFYGLLLTLPAVAIGVSLPYFISYLFLNKIQGWLERYPDQAAMLRAAGGGSWFHQFRAVTLIRISPFPFAVYNYCAVATRVKFGPYMAGSLVGMAPEIFVAIYTGILIRTLADASTAEQKGLSILQIVLNIFGFVATVVTTVLITKYAKRQLEVMKKEKEALLLQ
Protein: NAB transcription cofactor mab-10 (Protein male abnormal 10) (Q22002)
Organism: Caenorhabditis elegans
Function: Transcriptional cofactor. Heterochronic protein, involved in timing of a subset of differentiation events during the larval-to-adult transition. Promotes hypodermal terminal differentiation, together with transcription factor lin-29, perhaps as part of a transcriptional complex. Involved in regulating molting by repressing the expression of nuclear hormone receptors nhr-23 and nhr-25 in the adult hypoderm, probably acting in concert with lin-29.
Subcellular location: Nucleus {ECO:0000269|PubMed:21862562}.
Interaction partners:
- Zinc finger transcription factor lin-29
- Doublesex- and mab-3-related transcription factor dmd-3
- Protein lin-41
- Protein male abnormal 3
- CYCLIN domain-containing protein
Sequence:
MSSSSSSSLPTSSASTTTSSITSRPSASHHLESILSSSSSSPSILSSLTTQSTSSIPTSSSSSSQRQSTSNADRPVSPKPMPTPTTLSEWQLLAVLSKANLVQYYDVFIAQGGDDINQIMACEEREFLEIMNLVGMLPKPLHVRRMQRALAEYSQDQTAFNLAALQQIGPPPPLNYTPAGTDPMALLLPGIAAATSPKFPSLRFLSQLSSVAEKVSTPSEAADTSSSSPSLNLNTTSSNSVPLAFKFSTPLLESLASDQQSSSTSSVRSVLPSTSSNTSHPELPAGILPATTTNVSAAVPPPSSRATANVFSGNSIGLNFSGAASVTRHLVVPPSSTSIQQPSTSFGRSSSITGQEKEGSSSPFLGVGYSQPYGNDFVSLGDFDPNNPSLTENPTLSTAQISRLAECALAASKNLPPLPPRLVQNKKRVSKEVIELLKCSPATPSMIHAFRKYSAIYGRFDTKRKPHKVLTLHETTVNEAAAQLCLLVPSLLTRRDELFPLARQIVKDAGYNYAKSRKRPCDPADLHSPISSPGNSPPPQESEFDEQPSSSSGAFKEEERPPIPPEAWAAIIEKMKGELPES
Protein: FLUCTUATING-LIGHT-ACCLIMATION protein 1, chloroplastic (Q8RWI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:29016945}; Multi-pass membrane protein {ECO:0000255}. Plastid, chloroplast membrane {ECO:0000269|PubMed:29016945}; Multi-pass membrane protein {ECO:0000255}. Plastid, chloroplast envelope {ECO:0000269|PubMed:29016945}.
Interaction partners:
Sequence:
MASSSTFLELTPFQWNQPLPYTQRPHHRTVLLYSKPQRRSNSIRLQISVKYKQSTSSSDPDLRSNFNPFEQIAIQVKKALDSLKKPAIAAVLLGLLLFYDPNSALAASGGRIGGNSFSSRSRSSSSSSSQSYSVPRTSNPSFSYSARTAPYYGPSPFGGGFVGPAVGFGFGGFSSFSLILVGFAAFVLVSGFLSDRSQDDSILTDTQKTSVIKLQVGLLGLGRTLQQDFNRLAESSDTSTPEGLSYVLTEATLALLRHPDYCISCYSSVDVKPSIEKGEKRFNQLSIEERGKFDEETLVNVNSIKRQSSKIRKASGFSNEYIVVTILMAAEGIHKLPPINGTTDLKEALLKLGSIPRNKIMAVEVLWTPQNEADALSERELLEDYPLLRPL
Protein: Protein PHLOEM UNLOADING MODULATOR (EC 2.7.8.-) (Q9XIG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the biosynthesis of sphingolipids with very long-chain fatty acid (VLCFA). Required for the formation of plasmodesmal cytoplasmic sleeve during the transition from type I to type II plasmodesmata to modulate post-sieve elements (SE) unloading and symplastic cell-to-cell molecular trafficking at the phloem pole pericycle (PPP)-endodermis interface in roots.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- HSR201-like protein
- AT-hook motif nuclear-localized protein 10
- Protein DETOXIFICATION 33
- Methionine gamma-lyase
- Probable WRKY transcription factor 21
- Reticulon-like protein B6
Sequence:
MTKGGLGIAAMSYVVIDYMRYVSPVWHSRLMPVLWSVLAIAVVTRVLFYKHWSKELRAAIPFLGSIVFLLCALLFEALCVRSVTAVLGLDWHRETPPLPDTGQWFLLALNESLPGTLVEILRAHIIGLHHFLMLFIMLGFSVVFDSVKAPGLGLGARYIFTMGVGRLLRAITFVSTILPSARPWCASARFNNVPSQPHRWAQKYYVPYANDPAAIRKLLHWDAAYADPGSYIGDYRADWGSMSFLSEFLRPSYSEGSSWFALLKKAGGGCNDLMYSGHMLVAVLTAMAWTEAYGGFSSAMIWLFVAHSAQREIRERHHYTVDCIVAIYVGILLWKMTGFIWSAERKTKQTKLEKIQNSLIHAAKDGDIETVRRLVEEIEVSSRVEKQSKVISNRTMTVFACATVITTLTIVILALTLTSDG
Protein: Putative heat shock protein (G0RZX9)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Interaction partners:
- Putative ribosome associated protein
- J domain-containing protein
- Putative heat shock protein
- UBA domain-containing protein
- Mitochondrial protein import protein mas5-like protein
- Uncharacterized protein
- Putative heat shock protein
- Uncharacterized protein
- Heat shock protein hsp90-like protein
- Flavin reductase like domain-containing protein
Sequence:
MAESASKAAPGERVVIGITFGNSNSSIAHTVDDKAEVIANEDGDRQIPTILSYVDGDEYYGQQAKNFLVRNPKNTVAYFRDILGQDFKSVDPTHNHASAHPQEAGDNVVFTIKDKAEEDAEPSTLTVSEIATRYLRRLVGAASEYLGKKVTSAVITIPTNFTEKQKAALIAAAAAADLEVLQLISEPAAAVLAYDARPEATISDKIIVVADLGGSRSDVTVLASRSGMYTILATVHDYEYHGIALDKVLIDHFSKEFLKKNPGAKDPRENPRSLAKLRLEAESTKRALSRSTNASFSVESLIDGLDFASTINRLRYETIARTVFEGFNRLVESAVKKAGLDPLDVDEVIMSGGTSNTPRIAANFRYIFPESTRILAPSTDPSALNPSELQARGAALQASLIQEFETEDIEQSTHAAVTTMPHVTNAIGVVSVSESGEEKFVPIIAPETAVPARRTVHLDAPKEGGDVLVKVVEGSTHINVIKPEPKAKEDGETKEKTEDADDDGDFDDDDEEEEEEEEEEEKREKVWKIGSTLAEAAVRGVKKGAKVEVTINVNTDLTVIVTAREVGGKGGVRGTLSA
Protein: General transcription and DNA repair factor IIH subunit TFB2 (TFIIH subunit TFB2) (RNA polymerase II transcription factor B 52 kDa subunit) (RNA polymerase II transcription factor B p52 subunit) (RNA polymerase II transcription factor B subunit 2) (Q02939)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH subunit TFB4
- General transcription and DNA repair factor IIH subunit SSL1
- General transcription and DNA repair factor IIH subunit TFB5
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
- General transcription and DNA repair factor IIH subunit TFB1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- Cyclin CCL1
Sequence:
MSDYSLKHSVTQYLEEIPQQVQNRLYTSPATCLAIYRILPPLAKFFIMAMVFNENEVPLLDLDKWVNSNGKLQFQNAIKSMKSLHLLIPNKSSGTLMINLNPTFKISLRNALTGGEVQNSFGVVVEENVVSLDLLDEYSANKWETILHFMVGTPLAKIPSEKVLNLLKHSKLMEEVNSTGEFKITNEGFQFLLQEINSQLWTLLLQYLKMIETSKMDLVDVLHFIFMLGALEVGKAYKIDALSETQRIMLQDMRDYGLVFQKHSNDSIFYPTKLALMLTSDTKTIRSASNAMDSVLRQNREEPSVNEDGANGKSTTDITTSDDLNKAGLKNQDIPDGSLIVETNFKIYSYSNSPLQIAVLSLFVHLKARFVNMVLGQITRESIRRALTNGITADQIIAYLETHAHPQMRRLAEEKLEKKLELDPNCKEPLQVLPPTVVDQIRLWQLELDRVITYEGSLYSDFETSQEYNLLSKYAQDIGVLLWKDDKKKKFFISKEGNSQVLDFAKRKLKKKQ
Protein: Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (L3mt) (MRP-L3) (Q3ZBX6)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:16510155}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL27m
Sequence:
MPGWRLLAWAGARVLDRGTGGLGTALGSGNRTDICVLVRSLHGKSGTWWDEHLSEENVSFVKQLVSDENKAQLASKLCPLKDEPWPIHPWEPGSSRVGLVALKLGMMPLWTKDGKKHVVTLLQVQDCHVLKYTPKENHNGKMAALTVGGKTVSRFHKSTSILEFYQELGLPPKQKIKMFNVTDNAVIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPATHGQTKTHRRPGAISTGDVARVWPGTKMPGQLGNVDRTAFGLKVWRINTKHNIIYVNGSVPGHRNCLVKIKDSVLPAYKDFCKNLPFPTYFPDEDEKELPEDLYDEEVCQPGAPSITFV
Protein: Defective proboscis extension response 7, isoform F (A8DZ27)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dpr-interacting protein eta, isoform B
- Dpr-interacting protein theta
- Dpr-interacting protein kappa, isoform A
Sequence:
MSRGKHATFLNNSPIKIKPFIILVLNLNIWCQYISATSYLSLNDLTNLERPFFDDISPRNVSAVVDEIAILRCRVKNKGNRTVSWMRKRDLHILTTNIYTYTGDQRFSVIHPPGSEDWDLKIDYAQPRDSGVYECQVNTEPKINLAICLQVIADNDFQDLKTKKRFYDTKSARAKILGSTEIHVKRDSTIALACSVNIHAPSVIWYHGSSVVDFDSLRGGISLETEKTDVGTTSRLMLTRASLRDSGNYTCVPNGAIPASVRVHVLTGEQPAAMQTSSAIRIRAFTAMITIISTKVLLYISSLMEHMYLRER
Protein: Pentatricopeptide repeat-containing protein At4g30825, chloroplastic (O65567)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit TFB4
- DNA-directed RNA polymerase II subunit 4
- Cyclin-H1-1
- General transcription factor IIH subunit 2
- General transcription and DNA repair factor IIH subunit TFB2
- Transcription initiation factor IIF subunit alpha
- General transcription and DNA repair factor IIH subunit TFB1-1
- Transcription initiation factor IIA subunit 2
- Cyclin-dependent kinase D-2
Sequence:
MGSLRFSIPLDPFDSKRKRFHFSANPSQFPDQFPIHFVTSSIHATRASSIGSSTRVLDKIRVSSLGTEANENAINSASAAPVERSRSSKLSGDQRGTKKYVARKFSFRRGSNDLELENLFVNNGEIDVNYSAIKPGQSLEHCNGILKRLESCSDTNAIKFFDWMRCNGKLVGNFVAYSLILRVLGRREEWDRAEDLIKELCGFHEFQKSYQVFNTVIYACTKKGNVKLASKWFHMMLEFGVRPNVATIGMLMGLYQKNWNVEEAEFAFSHMRKFGIVCESAYSSMITIYTRLRLYDKAEEVIDLMKQDRVRLKLENWLVMLNAYSQQGKMELAESILVSMEAAGFSPNIIAYNTLITGYGKIFKMEAAQGLFHRLCNIGLEPDETSYRSMIEGWGRADNYEEAKHYYQELKRCGYKPNSFNLFTLINLQAKYGDRDGAIKTIEDMTGIGCQYSSILGIILQAYEKVGKIDVVPCVLKGSFHNHIRLNQTSFSSLVMAYVKHGMVDDCLGLLREKKWRDSAFESHLYHLLICSCKESGQLTDAVKIYNHKMESDEEINLHITSTMIDIYTVMGEFSEAEKLYLNLKSSGVVLDRIGFSIVVRMYVKAGSLEEACSVLEIMDEQKDIVPDVYLFRDMLRIYQKCDLQDKLQHLYYRIRKSGIHWNQEMYNCVINCCARALPLDELSGTFEEMIRYGFTPNTVTFNVLLDVYGKAKLFKKVNELFLLAKRHGVVDVISYNTIIAAYGKNKDYTNMSSAIKNMQFDGFSVSLEAYNTLLDAYGKDKQMEKFRSILKRMKKSTSGPDHYTYNIMINIYGEQGWIDEVADVLKELKESGLGPDLCSYNTLIKAYGIGGMVEEAVGLVKEMRGRNIIPDKVTYTNLVTALRRNDEFLEAIKWSLWMKQMGI
Protein: Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) (P09622)
Organism: Homo sapiens (Human)
Function: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:29211711, ECO:0000305|PubMed:3693355}. Nucleus {ECO:0000269|PubMed:29211711}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15888450}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}.
Interaction partners:
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Pyruvate dehydrogenase protein X component, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Sequence:
MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
Protein: No long nerve cord, isoform A (EC 3.4.24.-) (Q9V9Q7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSVNMNWTSPKIWAALFVTTLCLLDTQAAWAKKLNASQAFDDTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGSCRGESTRYRICNMQPCPEQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSICDEYERPAMRQECYNERCEGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRPAVMKVCKSPACQAQLSSSPAQLCRDSSRYCRNARAMGLCRLHRYKLKCCGSCEQQPNQHLIL