wanglab/gogpt-training-data huggingface dataset:
Protein: Cadherin-8 (P97291)
Organism: Mus musculus (Mouse)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Catenin beta-1
- Catenin alpha-2
- Cadherin-12
- Junction plakoglobin
- Cadherin-7
- Cadherin-20
- Cadherin-4
- Cadherin-13
- Catenin delta-1
- Cadherin-9
Sequence:
MPERLAETLMDLWTPLIILWITLPSCVYTAPMNQAHVLTTGSPLELSRQSEDMRILSRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSSRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET
Protein: Protein URE2 (E9P8I0)
Organism: Saccharomyces cerevisiae (Baker's yeast)
Interaction partners:
Sequence:
MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
Protein: Transcription factor Sp3 (SPR-2) (Q02447)
Organism: Homo sapiens (Human)
Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.
Subcellular location: Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Interaction partners:
- Transcription factor Sp1
- Histone deacetylase 1
- Estrogen receptor
- Histone deacetylase 2
- Histone acetyltransferase p300
Sequence:
MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
Protein: Axial regulator YABBY 3 (Q9XFB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the abaxial cell fate determination during embryogenesis and organogenesis. Regulates the initiation of embryonic shoot apical meristem (SAM) development. Contributes to the repression of KNOX genes (STM, KNAT1/BP and KNAT2) to avoid ectopic meristems. Binds DNA without sequence specificity.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Probable transcription factor KAN2
- Transcription repressor KAN1
- Protein ASYMMETRIC LEAVES 2
- Zinc finger protein JAGGED
- Transcription factor AS1
- WUSCHEL-related homeobox 1
- BEL1-like homeodomain protein 9
- Probable transcription factor KAN3
- WUSCHEL-related homeobox 3
- Auxin response factor 3
Sequence:
MSSMSMSSSSAPAFPPDHFSSTDQLCYVHCSFCDTVLAVSVPPSSLFKTVTVRCGHCSNLLSVTVSMRALLLPSVSNLGHSFLPPPPPPPPPNLLEEMRSGGQNINMNMMMSHHASAHHPNEHLVMATRNGRSVDHLQEMPRPPPANRPPEKRQRVPSAYNRFIKEEIQRIKAGNPDISHREAFSAAAKNWAHFPHIHFGLMADHPPTKKANVRQQEGEDGMMGREGFYGSAANVGVAHN
Protein: Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) (Probasin-related antigen) (PRB-RA) (P18757)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (Probable). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate. Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (Probable).
Subcellular location: Cytoplasm.
Interaction partners:
- Cystathionine beta-synthase
- 3-mercaptopyruvate sulfurtransferase
- Thiosulfate sulfurtransferase
- Methionine synthase
- Betaine--homocysteine S-methyltransferase 1
- Cysteine dioxygenase type 1
- Methylenetetrahydrofolate reductase
- Kynurenine--oxoglutarate transaminase 1
- Adenosylhomocysteinase
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
Sequence:
MQKDASSSGFLPSFQHFATQAIHVGPEPEQWSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP
Protein: PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) (Q8SY07)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
MLTDTEDDFFFEEDKMGMTVSTNAVVITKDQSNLIGISIGGGAPMCPCLYIVQIFDGTPAAREGSLQSGDELLAVNSVSVKGKTKVEVAKMIQTATDEVVIHYNKLHADPEQGKTLDIILKKLKHRIVDNLSSNTADTLGLSRAILCNDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFGDCFTQISVHEPQQRASEAFRTFGEFHRTLEKDGLGIIKQIKPVLADLGTYLNKAIPDTKLTVRRYADAKFTYLSYCLKVKEMDDEEHGFAALQEPLYRVETGNYEYRLILRCRQDARSKFAKLRTDVLEKMELLECKHAMDLNKQLRSLLESLAELHRSLVDRLDSLPPLFPIEVDFKETDFQYKSSTLKPQELDDDEIEANNHPHSTPSQVDCGFEAVEQPAAIINVEAAKASVDSSTLQSASENETLLKELGLYDVDLLSNPQTISNQKDSIAAQNDGYDFDLFLNQATAATTSLERDLMSSNAEEMDLLLQ
Protein: Structure-specific endonuclease subunit SLX1 homolog (EC 3.1.-.-) (Q9VN41)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03100}.
Interaction partners:
- Structure-specific endonuclease subunit SLX4
- Crossover junction endonuclease MUS81
- DNA excision repair protein ERCC-1
- DNA repair endonuclease XPF
- Methyl methanesulfonate sensitivity 4
- RecQ-like DNA helicase Blm
- Exonuclease 1
- Actin-related protein 2/3 complex subunit 4
- DNA topoisomerase 3-beta
- Fanconi anemia group D2 protein homolog
Sequence:
MNSYDPQDTASQQEESVALKGHFYGVYLLCSQSLDPRYRGKCYVGFTVNPKRRIRQHNLGCDFGGARKTSRKGPWLMVMIVHGFPNNTVALQFEWAWQQPSLSTRLKMYPELKRKLPRETFFDYNFRILSNMLGVGPWNRLPLTVRWLETDYERPFSKALPKHMEIVSGKVSISASQRRRPDDAVPPPPVAWASECHLCMQEMEQPEKSRLGCTNQMCRLTCHMVCLANYLLGDEPGHYIPVGGECPLCETRLSWAALLQRKRLLLGVPEELQDHDEDLSDDIDVDSDIEDTPELSD
Protein: Receptor protein kinase-like protein ZAR1 (EC 2.7.11.1) (Protein ZYGOTIC ARREST 1) (Q9ZU46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor protein kinase acting as an integrator for intracellular calcium and heterotrimeric G protein signaling with extracellular signals during early zygote development. Involved in modulating the asymmetric division of zygote and the cell fate determination of its daughter cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27014878}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- non-specific serine/threonine protein kinase
- LRR receptor-like Serine/Threonine-kinase
- Uncharacterized aarF domain-containing protein kinase At1g71810, chloroplastic
- Protein KINASE OF THE OUTER CHLOROPLAST MEMBRANE 1
- Uncharacterized aarF domain-containing protein kinase At5g05200, chloroplastic
- Ethylene-responsive transcription factor RAP2-9
Sequence:
MLASLIIFVALLCNVTVISGLNDEGFALLTFKQSVHDDPTGSLNNWNSSDENACSWNGVTCKELRVVSLSIPRKNLYGSLPSSLGFLSSLRHLNLRSNRFYGSLPIQLFHLQGLQSLVLYGNSFDGSLSEEIGKLKLLQTLDLSQNLFNGSLPLSILQCNRLKTLDVSRNNLSGPLPDGFGSAFVSLEKLDLAFNQFNGSIPSDIGNLSNLQGTADFSHNHFTGSIPPALGDLPEKVYIDLTFNNLSGPIPQTGALMNRGPTAFIGNTGLCGPPLKDLCQGYQLGLNASYPFIPSNNPPEDSDSTNSETKQKSSGLSKSAVIAIVLCDVFGICLVGLLFTYCYSKFCACNRENQFGVEKESKKRASECLCFRKDESETPSENVEHCDIVPLDAQVAFNLEELLKASAFVLGKSGIGIVYKVVLENGLTLAVRRLGEGGSQRFKEFQTEVEAIGKLKHPNIASLRAYYWSVDEKLLIYDYVSNGNLATALHGKPGMMTIAPLTWSERLRIMKGIATGLVYLHEFSPKKYVHGDLKPSNILIGQDMEPKISDFGLARLANIAGGSSPTIQSNRIIQTDQQPQERQQHHHKSVSSEFTAHSSSGSYYQAPETLKMVKPSQKWDVYSYGIILLELIAGRSPAVEVGTSEMDLVRWVQVCIEEKKPLCDVLDPCLAPEAETEDEIVAVLKIAISCVNSSPEKRPTMRHVSDTLDRLPVAGD
Protein: Arginine repressor (O85175)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: Regulates arginine biosynthesis genes.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Arginine biosynthesis bifunctional protein ArgJ
- Ornithine carbamoyltransferase
- N-acetyl-gamma-glutamyl-phosphate reductase
- Acetylglutamate kinase
- Argininosuccinate synthase
- Acetylornithine aminotransferase
- Argininosuccinate lyase
- Glutamate 5-kinase
- LexA repressor
- Uncharacterized protein Cgl1270/cg1434
Sequence:
MSLGSTPSTPENLNPVTRTARQALILQILDKQKVTSQVQLSELLLDEGIDITQATLSRDLDELGARKVRPDGGRAYYAVGPVDSIAREDLRGPSEKLRRMLDELLVSTDHSGNIAMLRTPPGAAQYLASFIDRVGLKEVVGTIAGDDTVFVLARDPLTGKELGELLSGRTT
Protein: Calcium-dependent protein kinase 1 (B2D2I9)
Organism: Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Interaction partners:
Sequence:
MGCCSSKEKPSKSEANKGYRSGGTGNLRQNQQQQSYYQQPEYQQQQAVQHPKMTVPQTQTQTPQTRPQQPQASTPPPVRAAPTNLTARSVQTPQTILGKPLEDIKQYYSLGKELGRGQFGVTYLCTENSTGHIYACKSILKRKLINKGDREDIKREVQIMQHLSGQPNIVEFRGSYEDRQSVHVVMELCAGGELFDRIIAKGHYSERDAARICKDIVNVVHACHFMGVMHRDLKPENFLLASKDEGAMLKTTDFGLSVFIEEGKTYRNIVGSAYYVAPEVLRRSYGKEIDIWSAGVILYILLSGVPPFWAETEKGIFDAILEGYIDFESSPWPSISDSAKDLVRRMLTQDPKRRITSAQVLDHPWIKDGGAASDKPIDSAVLSRMKQFRAMNKLKKLALKVIAENLSEEEIKGLKAMFTNMDTDKSGTITYEELKTGLARLGSRLSETEVKQLMEAADVDGNGAIDYIEFISATMHRYRLERDEHLYKAFQYFDKDSSGYITRDELESAMMEYGMGDEASIKEIISEVDTDNDGKINYEEFCTMMRRGVQQPGKLF
Protein: Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Low density lipoprotein receptor-related protein 4) (Pro-ANP-converting enzyme) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment] (Q9Z319)
Organism: Mus musculus (Mouse)
Function: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted {ECO:0000250}. Note=Soluble form produced following cleavage by ADAM10. {ECO:0000250}.
Interaction partners:
- Natriuretic peptides A
Sequence:
MGRVSFSVRVSSVRRARCSCPGRCYLSCRVPPTTALRALNGLGCAGVPGETAGGAVGPGPLGTRGFLSGSKFQAPGSWKDCFGAPPAPDVLRADRSVGEGCPQKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKRVYFKSNDSEPLVTDGEARVPGVIPVNTVYYENTGAPSLPPSQSTPAWTPRAPSPEDQSHRNTSTCMNITHSQCQILPYHSTLAPLLPIVKNMDMEKFLKFFTYLHRLSCYQHILLFGCSLAFPECVVDGDDRHGLLPCRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRDHTETNSSVRKSCFSLQQEHGKQSLCGGGESFLCTSGLCVPKKLQCNGYNDCDDWSDEAHCNCSKDLFHCGTGKCLHYSLLCDGYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCHSQGLVECRSGQCIPSTFQCDGDEDCKDGSDEENCSDSQTPCPEGEQGCLGSSCVESCAGSSLCDSDSSLSNCSQCEPITLELCMNLPYNHTHYPNYLGHRTQKEASISWESSLFPALVQTNCYKYLMFFACTILVPKCDVNTGQRIPPCRLLCEHSKERCESVLGIVGLQWPEDTDCNQFPEESSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERALWECPFNKQCLKHTLICDGFPDCPDSMDEKNCSFCQDNELECANHECVPRDLWCDGWVDCSDSSDEWGCVTLSKNGNSSSLLTVHKSAKEHHVCADGWRETLSQLACKQMGLGEPSVTKLIPGQEGQQWLRLYPNWENLNGSTLQELLVYRHSCPSRSEISLLCSKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPSPEEYLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVGWIERQIYIQTFLQKKSQG
Protein: Uncharacterized protein YfaA (P17994)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YfaT
- Uncharacterized protein YfaP
- Uncharacterized protein YfaQ
- Uncharacterized protein YahF
Sequence:
MSGEKKAKGWRFYGLVGFGAIALLSAGVWALQYAGSGPEKTLSPLVVHNNLQIDLNEPDLFLDSDSLSQLPKDLLTIPFLHDVLSEDFVFYYQNHADRLGIEGSIRRIVYEHDLTLKDKLFSSLLDQPAQAALWHDKQGHLSHYMVLIQRSGLSKLLEPLLFAATSDSQLSKTEISSIKINSETVPVYQLRYNGNNALMFATYQDKMLVFSSTDMLFKDDQQDTEATAIAGDLLSGKKRWQASFGLEERTAEKTPVRQRIVVSARWLGFGYQRLMPSFAGVRFEMGNDGWHSFVALNDESASVDASFDFTPVWNSMPAGASFCVAVPYSHGIAEEMLSHISQENDKLNGALDGAAGLCWYEDSKLQTPLFVGQFDGTAEQAQLPGKLFTQNIGAHESKAPEGVLPVSQTQQGEAQIWRREVSSRYGQYPKAQAAQPDQLMSDYFFRVSLAMQNKTLLFSLDDTLVNNALQTLNKTRPAMVDVIPTDGIVPLYINPQGIAKLLRNETLTSLPKNLEPVFYNAAQTLLMPKLDALSQQPRYVMKLAQMEPGAAWQWLPITWQPL
Protein: Coiled-coil domain-containing protein 87 (Q8CDL9)
Organism: Mus musculus (Mouse)
Function: Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.
Interaction partners:
Sequence:
MEPHSQEPDLKPIYHRLLSPLSLFPSKAKPPPEPPKRPSQDATPLQSIPLAKLKVGPLCRQVSKRLASSGRAARVTAKDRLRLTEVILEELKCNWREPPIEPILDYENNQKLRQRLESYVLISSEQLFVRYLHLLVTLPTSRRVFTESATLSRLAVNLARDCTVFLTSPDVYRCLLADFQTLLNLKHAQGGIVKLRPPPCPPGTFKLCPIPWPHSTGLDHMPCSSLNLNYLVQLSRPYDFPSEPEPDPVEELKSIPQLKSRQQLLWVPSMIKDKEIESRPSPMVPLPSHSPSSESHQFPTSPVHSWLQRGQSMPCLHEGWSLADELCLLPPSPHPLTPLILASESKPLPFRDIVAEDLKQKMKIMRMEWSRYSLLDSGLPPLLGVLTRRLTAQHHLEKLQQMIKSLQEEEASGKWDLQPPRIIPLHPQPVTVALKVHDQVIVQVATVQLSERYFNDSFHVEGAGVLYNHLTGELDGKAIEEMDADRLVGNTTGEVYKELMSRVSVSHLSFEEGDQIEPSADKDWSSYLASSFLHQDKHMPIINRNLVGFYSRRTSTPKPVPEKVPSLTLLPRHKSWDKRPNRHGVWMNWLKPSVSSEDYFKYLSFQESDFLHVIFQMYEKEAPVEVPVPVQEYLDIQQPPPLLQDEELEFMQGKWDWSSVIEDGSGPGRAYIHNLQQRLKRLWVMLEVPEQNRLDMVIKYSSNARLQQLPALIKAWEQVLKPIQKRESLLGRLEWFEQQASDPNRFFQKPDLLMNRLLEENRFRSYLQRKLNRMESNLVSLLERIESVFGEPVTFKGRSYLKKMKQDKVEMLYWLQQQRRIRNLTQAQKTFRQSCTFTGSSSQALVAPGNTPTTH
Protein: Noggin (P49011)
Organism: Xenopus laevis (African clawed frog)
Function: Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface receptors. Capable of inducing dorsal development in embryos. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with xWNT-8 and nuclear, sequence-specific DNA-binding protein xBRA. None of these molecules causes dorsal mesoderm formation when expressed alone.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MDHSQCLVTIYALMVFLGLRIDQGGCQHYLHIRPAPSENLPLVDLIEHPDPIYDPKEKDLNETLLRTLMVGHFDPNFMATILPEERLGVEDLGELDLLLRQKPSGAMPAEIKGLEFYEGLQSKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKRSCSVPEGMVCKAAKSMHLTILRWRCQRRVQQKCAWITIQYPVISECKCSC
Protein: Cytochrome P450 monooxygenase patH (EC 1.-.-.-) (Patulin biosynthesis cluster protein H) (m-cresol hydrolase) (A0A075TRL5)
Organism: Penicillium expansum (Blue mold rot fungus)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. PatH catalyzes the conversion of m-cresol into m-hydroxybenzyl alcohol. The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30680886}; Single-pass membrane protein {ECO:0000269|PubMed:30680886}.
Interaction partners:
Sequence:
MEPFLLLLLVLLPAIVLVRYAFTYGHRTSTMPIGPPTLPFIGNIHQITKKYTHIKFTEWAAQYGGLYMLKIGNGNMAVITDRRLVKEVLDRKSGIYSHRPHSFVSHDLITKGNHLLVMHYGDQWRTFRRLVHQHLMETMVENHHTKIVNAEAIQLVRDYMIDPEHHMAHPKRYSNSITNSIVFGIRTANREGANMRRLYKLMEEWSEVMETGATPPVDLFPWLKLLPQWLFNNYIDRAKAIGVQMETLYVDILNKVIKRREDGHNNGTFMDKVLDSQEKHNLPWHQLAFIGGVLMEGGSDTSSSLTLAIVQALIQNPDVQRKAHAEIDAVVGHNRSPVWEDFEKLPYINMIIKEGHRWRPILPLCFPHALGEDDWVDGKFLPKGTIVVVNTWGMHMDPSQPDDPAAFIPERFAKHPQLAPDYVPGTWERRDHYGYGVGRRICPGIHLAERNMFLGIAKLLWAFDFQPGEGPIDSDPVTGYHNGFLYCAKDYSCRPVIRNEVIRDTIEREYATATADVFSRFTEG
Protein: G protein subunit alpha transducin 3 (F1P3R0)
Organism: Gallus gallus (Chicken)
Interaction partners:
- G protein subunit gamma 13
- Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- G protein subunit beta 1
- G protein subunit beta 4
- G protein subunit beta 3
- RGS domain-containing protein.
- WD_REPEATS_REGION domain-containing protein.
- Regulator of G protein signaling 11.
- Regulator of G protein signaling 9.
- G-protein-signaling modulator 2
Sequence:
MGGGASSESKESARRSRELEKKLQEDAEREARTVKLLLLGAGESGKSTIVKQMKIIHKDGFTYQERMEFRPIIYSNTVQSILSIVKAMTKLGISYENPARIEDERKLCDMETNLDDSNMSSELVELIKQLWKDGGIQACFARASEYELNDSAAYYLNDLDRLAMPDYVPSEQDVLHSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDKEVNRMHESLQLFNSICNHRCFATTSIVLFLNKKDLFQEKIAKVHLNICFPEYNGLNTFEDAGNYIKKQFLDLNIRKEDKEIYCHLTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
Protein: Nuclear receptor subfamily 1 group I member 3 (Constitutive androstane receptor) (CAR) (Q9QUS1)
Organism: Rattus norvegicus (Rat)
Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.
Interaction partners:
- Retinoic acid receptor RXR-alpha
- Nuclear receptor coactivator 2
- Nuclear receptor coactivator
- Cytochrome P450 2B3
- Cytochrome P450 2B1
- Nuclear receptor subfamily 0 group B member 2
- Cytochrome P450 3A1
- Cytochrome P450 1A2
- Retinoic acid receptor RXR-gamma
- Cytochrome P450 2B2
Sequence:
MTATLTLETMTSEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQARRRAQKASLQLSQQQKELIQTLLGAHTRHVGPMFDQFVQFRPPAYLFSHHRPFQPLAPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTQNFFCGPLCYKMEDAVHVGFQYEFLELIIHFHKTLKRLQLQEPEYALMAAMALFSPDRPGVTQREEIDQLQEEVALILNNHIMEQQSRLQSRFLYAKLMGLLAELRSINSAYSYEIHRIQGLSAMMPLLGEICS
Protein: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 7.1.1.2) (O22769)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}. Note=Matrix and cytoplasmic side of the mitochondrial inner membrane. {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- NADH dehydrogenase 1 alpha subcomplex subunit 8-B
Sequence:
MLARLAAKRLLEIRQVFRQPTSQVTRSLSTALNYHLDSPDNKPDLPWEFSEANQSKVKEILSYYPSNYKQSAVIPLLDLAQQQNGGWLPVSAMNAVAKVIEVAPIRVYEVATFYSMFNRAKVGKYHLLVCGTTPCMIRGSRDIESALLDHLGVKRGEVTKDGLFSVGEMECMGCCVNAPMITVADYSNGSEGYTYNYFEDVTPEKVVEIVEKLRKGEKPPHGTQNPKRIKCGPEGGNKTLLGEPKPPQFRDLDAC