wanglab/gogpt-training-data huggingface dataset:
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (E7F1L8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Lymphoid enhancer-binding factor 1
- Transcription factor 7-like 2
- Transcription factor 7.
- Transcription factor 7-like 1-A
- Mitogen-activated protein kinase kinase kinase 7.
- Forkhead box O3b.
- Forkhead box O4
- Forkhead box protein O1-A
- Forkhead box O3A
- Forkhead box protein O1-B
Sequence:
MALCGTTASNAAKMMAAYNGGTAAVAAHHPHHHHQLPHLPPPAHLHHHHHAGQHHLQHPGSAAAVHPVQQHASTAAAAAAAAAAAVMLNPSQQQPYFPSPAPGQAPGPAAAAAPAQVQAAAAAAVKVHHHHHQHSHHLQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGARAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCYTTSSGRVYTSDFEPVTNPKFDDGFEKNLTSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Protein: T-box brain transcription factor 1 (D4A6N8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
- DNA-binding protein SATB
- BCL11 transcription factor B
- Paired box protein Pax-6
- Homeobox protein cut-like 1
- Zinc finger protein 312
- Neurogenic differentiation factor.
- Empty spiracles homeobox 1
- Forkhead box protein G1
- Nestin
- Glial fibrillary acidic protein
Sequence:
MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS
Protein: Amino-acid permease GAP5 (A0A1D8PMB1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Amino-acid permease that is able to transport phenylalanine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21764911, ECO:0000269|PubMed:28028545}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSKKYSEENTSSIPLTDLTSPSTGETSSQQQRQRASQQQPPQQPESNTATGSRWSNFVDSFKPAIENEKLAMRYRDANADVEEDAGGYYNSTDQLTEIQRININSSKSNLKRKLKNRHLQMIAIASSIGSGLLIGTGGALATGGPGGILIAWILSGISILCTIQAMAELAVTFPVSGGFNVLFSRFIDPSVGFSVAWNYVLQYLVLLPLELVAASMTIQYWNTDINPDVWVIIFYVTVTSINFFGVRLYGEVEFILSSLKVIAVVGFIILSIVLAAGGAPNGVHHGTKYWHDPGAFANGFKGVSSTFITAAFSFAGTELTGLTSAEAENPRKALPKACKQVFWRILLFYVVSIILITFLVPYDNPRLLGASDVSASPFVIAIQDGGISGLASVMNSVILISVISVGSSSVYATSRTLVSLAEQNLAPKICGYVDRAGRPLVAILITNVFGLLSFIAASGKEDEVFTWLLSISGLSSIFTWLCICISHIRFRRALHVQGRNTDELTFVSQTGVIGSWFGILLNVLVLVAEFWLAIFPLGEKSNAKSFFETYLGFVILIIFYFGHKLWRNNWILFIRSRDIDIDSGRRETDLEALKRELQEEREVLRNKPFWYRAYHFWC
Protein: TolB protein-like protein (Q9SYI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
METPKGTIIFTTVGRTHYGFDVFSLNIATSVERRLTDGVSVNFNAQFVNDKSDDVVFVSERNGSARIYKTRSGISKPEQIPGAPESYFHDRPIITQNNRLYFISAHEQPDRYFKNWSALYTVELNSAKREVTRVTPPDTADFSPAVSQSGDFLAVASYGTRSWGGEFHEINTDITVFKASKPETRVVICERGGWPTWSGDSTVFFHHQADDGWWSIFRVDIPENFTEYTDFPITPIRVTPSGLHCFTPAAFRDGKRIALATRRRGVNHRHIEIYDLENTTFQPVTESLNPSFHHYNPFVSPDSEFLGYHRFRGESTQGESIVPNIESIVSPIKTLRLLRINGSFPSSSPNGDLIALNSDFDINGGIKVSKSDGSKRWTLIKDRTAFYNSWSPTERHVIYTSLGPIFSPARIAVQIARIKFDPSDLTADKEDLPCDVKILTLENTGNNAFPSCSPDGKSIVFRSGRSGHKNLYIVDAVNGESNGGGIRRLTDGPWIDTMPCWSPKGDLIGFSSNRHNPENTAVFGAYVVRPDGTGLRRIQISGPEGSEEAARERVNHVSFNKDGDWLVFAANLSGVTAEPVTMPNQFQPYGDLYVVKLDGTGLRRLTWNGYEDGTPTWHTADELDLSQLNLNGQDGDKLEGQFEEPLWISCDI
Protein: Actin-related protein 5 (Q80US4)
Organism: Mus musculus (Mouse)
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H9F9}.
Interaction partners:
- INO80 complex subunit C
- RuvB-like 1
- RuvB-like 2
- Nuclear factor related to kappa-B-binding protein
- Chromatin-remodeling ATPase INO80
- Actin-related protein 8
- INO80 complex subunit E
- INO80 complex subunit B
- Actin-like protein 6A
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
Sequence:
MEANVFRFRDARSAPDPVLEAGPVAFGSQPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGPGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYRIPKVAYGIDSLFSFYHNVPKNALSSGLIISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYGAELQKWQCPDYYENNVHKMQLPFSSKLLGSTLTAEEKQERRQQQLRRLQELNARRREEKLQLDQERLERLLYVQELLEEGQMDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEASLEVDVVDSKPETPDLEPLEPTMEDVENISDFEPLFSEETPEVEKPQVTTVQPVFNLAAYHQLSVGTERIRAPEIIFQPSLIGEEQAGIAETLHFVLDRYPKAIQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYEEKGGEYLKEHCASNTYVPIRLPKQASRASETQTSGRGSSASGSGAG
Protein: LRRC7 protein (A1L1C6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTKMLGKLRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHSRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
Protein: Alpha-elapitoxin-Oh3a (CM-11) (Long neurotoxin OH-55) (Q53B58)
Organism: Ophiophagus hannah (King cobra) (Naja hannah)
Function: Binds to muscular and neuronal nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. Pseudo-irreversibly inhibits twitches in chick biventer cervicis nerve-muscle preparations in a concentration-dependent manner.
Subcellular location: Secreted {ECO:0000269|PubMed:15302536, ECO:0000269|PubMed:35341214, ECO:0000269|Ref.2}.
Interaction partners:
Sequence:
MKTLLLTLVVVTIVCLDLGYTTKCYVTPDVKSETCPAGQDICYTETWCDAWCTSRGKRVNLGCAATCPIVKPGVEIKCCSTDNCNPFPTRKRP
Protein: Synaptosomal-associated protein (A8K287)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS
Protein: Uncharacterized protein (Q387D0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDFVDINVNTQPARANTISWFDAISPGRASRVVTPATCPPPSSTNMSTKEIRQSDLAVTQRHQENDLTVSTICYDDESNSSLLRRLNSTVTPPRPHTNLTDGEMGTSVVLGEYSTAAAASPQRRMVSSGAVPRSRRRCDDMYEEAVRGKLAKRQWAAAEQIRQSILERARIERDCTFQPQLSPYAKKLHRPSHLAPENRIYEELMRKSEWRAQKQKEHIEDELKGCTFRPLTVQAAKLKSSAHVRDSHIFSELYNHHEEQQYFRDELRPRVVQHLEQQILYKNPSNKIVSENKMSEVVERLISRGAIVQADRQRAKSAAISSETFKPAISTKSERIVSRQQDAGLLSEDVLERLMNPPKTMSQDRCQRREREEKLFDEDFKEICSEYLKGVRVSLRKELEKNFISAKFDALADYIHREEPDYKGCDSRVDKYPIKQLLKAAVSILSAEEGDELVHILTHSRSPALNRKGFVTLCLKALAVVEDPRSSALASLPPPPSNSGNGNRTGFVDNTDKNRRDHLNRLRHNMSPEEVAAIKASALERQQRRTEEELQRQRAKEEEEMRECTFRPQTTRKIPRECRSGRYTNVRITKGEMLRRAHIRKSRTESVETPSLDLPIPLVRDIFKKLKIPTAFPSPQRRAHSAGAHPGVCGKHRQIRTTAVLKSPKQRVKSTSRRSRAEGDQQGVATRAASAVDKKSHFPAKSKGKEEAACAAVPSEQSSEDAAETYTGRSFDGNPWPNAGALFRDAASEHGVFGGEGALTDLGRQLILQQLREYRSRQR
Protein: Protein TIC 40, chloroplastic (Protein PIGMENT DEFECTIVE EMBRYO 120) (Translocon at the inner envelope membrane of chloroplasts 40) (AtTIC40) (Q9FMD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. Part of the motor complex consisting of a co-chaperone (TIC40) and a chaperone (HSP93) associated with the import channel (TIC110). Causes the release of bound transit peptides from TIC110 and stimulates ATP hydrolysis by HSP93. Involved in reinsertion of proteins from the chloroplast stroma into the inner membrane.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:12805212, ECO:0000269|PubMed:17060496, ECO:0000269|PubMed:17535810, ECO:0000269|PubMed:17883373}; Single-pass membrane protein {ECO:0000269|PubMed:12805212, ECO:0000269|PubMed:17060496, ECO:0000269|PubMed:17535810, ECO:0000269|PubMed:17883373}.
Interaction partners:
- Protein TIC110, chloroplastic
- Chaperone protein ClpC1, chloroplastic
- Protein TIC 22, chloroplastic
- Short-chain dehydrogenase TIC 32, chloroplastic
- Protein TOC75-3, chloroplastic
- Protein TIC 55, chloroplastic
- Translocase of chloroplast 159, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- Protein TIC 62, chloroplastic
- Protein TIC 56, chloroplastic
Sequence:
MENLTLVSCSASSPKLLIGCNFTSSLKNPTGFSRRTPNIVLRCSKISASAQSQSPSSRPENTGEIVVVKQRSKAFASIFSSSRDQQTTSVASPSVPVPPPSSSTIGSPLFWIGVGVGLSALFSYVTSNLKKYAMQTAMKTMMNQMNTQNSQFNNSGFPSGSPFPFPFPPQTSPASSPFQSQSQSSGATVDVTATKVETPPSTKPKPTPAKDIEVDKPSVVLEASKEKKEEKNYAFEDISPEETTKESPFSNYAEVSETNSPKETRLFEDVLQNGAGPANGATASEVFQSLGGGKGGPGLSVEALEKMMEDPTVQKMVYPYLPEEMRNPETFKWMLKNPQYRQQLQDMLNNMSGSGEWDKRMTDTLKNFDLNSPEVKQQFNQIGLTPEEVISKIMENPDVAMAFQNPRVQAALMECSENPMNIMKYQNDKEVMDVFNKISQLFPGMTG
Protein: NADPH:adrenodoxin oxidoreductase, mitochondrial (EC 1.18.1.6) (A0A0C4DFN8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|PIRNR:PIRNR000362}.
Interaction partners:
Sequence:
MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVPELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH
Protein: Tight junction protein 1 (A0A087X0K9)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
Protein: alpha-1,2-Mannosidase (EC 3.2.1.-) (Q57W80)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MKGAQFLKMPCVRVLLVLVRVFFVHLPSFAFGDAFPVNGARGGNSQGYNTDGMHPIQAEMLPYVRDMIDHAFGSYIKYAFPKDELCPVSGTGKNTMGGYGWTLIDSLDTLAIAGFHKEFRRHAKWVEEHLTFDIDESVSVFETTIRALGGLLAAHFMYEEGIVPIIPSEHDYNGGFLRLAVDLADRLMPCFDTPTGIPYGKVNLRSKSKEMWISRSNTAEVGTMLMEMTVLSRITGDEKYERAARRASEALFAARDSQTELMGTYVSVSSGGFSSSESSVAGNIDSAIEYFIKSHSMSGDIGDWERFERTARAVNRYVRKGGMLLAASMYSGRRLQTSQESLSSFFPGNLVLGGHLHEAVESSWPIHTFFKHFGVLPEIFSLESGEPSWISHDYIGRPEHIESLYMLYRATRDPTYLLMGKELALAINLRMRTPYGFSSVSDVRYPHHDGVHRDSMESFMIAETLKYLYLLFDECNAVHMQGRMGGRASPHCVMDSGSGSSVSHVGWVFNTEAHLFPNSAEWWAPTSLETLDKEAEDPAAALRRQRLEVIDGLLASFEEVDGEVVGANDKGGAALYQFHCANHALSDVGRLSKSVFR
Protein: TauPI-stichotoxin-Hcr2b (TauPI-SHTX-Hcr2b) (Analgesic polypeptide HC1) (APHC1) (B2G331)
Organism: Radianthus crispa (Leathery sea anemone) (Heteractis crispa)
Function: This protease inhibitor shows two different activities, it inhibits both the capsaicin receptor TRPV1 and serine proteases. It partially (max 50%) and reversibly inhibits capsaicin-induced response of TRPV1 (IC(50)=54 nM), a receptor of the pain pathway. The second activity is a weak inhibition of trypsin and chymotrypsin activity (Ki=1 uM and Ki=5 uM, respectively). In vivo, it shows antinociceptive and analgesic activities. It significantly prolongs tail-flick latency and reduces capsaicin-induced acute pain. In vivo, unlike other TRPV1 antagonists whose activity is associated with hyperthermia, this protein has the remarkable feature of dropping core body temperature.
Subcellular location: Secreted {ECO:0000269|PubMed:18579526}. Nematocyst {ECO:0000269|PubMed:18579526}.
Interaction partners:
Sequence:
MKGTFLICLILIAGFSFKSTQAGSICLEPKVVGPCTAYFRRFYFDSETGKCTVFIYGGCEGNGNNFETLRACRAICRA
Protein: DNA polymerase III gamma-tau subunit (E7DN82)
Organism: Pneumococcus phage Dp-1 (Bacteriophage Dp-1)
Interaction partners:
Sequence:
MIGQGLVKSTISKWKQLPKYIIVEGEVGSGRKTLIRYIASKFDADSIVVGTSVDDIRNIIQDAQTIFKARIYVIDGNSLSMSALNSLLKIAEEPPLNCHIAMTVDSINNALPTLASRAKVLTMLPYTNEEKMQFVKSYKKVDTSGIDDRAIVDYCNLASNLQMLEDILEYGAEELFEKVTTFYDLIWEASASNSLKVTNWLKFKETDEGKIEPKLFLNCLLNWSTVVIRKHYVEMSFEELEAHDLLVREASRCLRKVSKKGSNARVCVNEFIRRVKQVE
Protein: PAB1-binding protein 2 (P38151)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- PAB1-binding protein 1
- Heterogeneous nuclear rnp K-like protein 2
Sequence:
MSTETTKPSITTTPTTVLVSPNTLKRKKGEDTSEEQLEAEIKRVALKDADSHSDNDHDSPDNVPSDVHLRMLCLVKHASLIVGHKGATISRIKSETSARINISNNIRGVPERIVYVRGTCDDVAKAYGMIVRALLEEHGNEDNGEDIEISINLLIPHHLMGCIIGKRGSRLREIEDLSAAKLFASPNQLLLSNDRILTINGVPDAIHIATFYISQTLLNFQMESPQKNVKRSIYYQPTQFNSVLIDHSQPNTIFHQRNHQYHPSDKLLSYKPNKNLPISSTLLSMATPQYTTASVANATAFQPNFVIPNVTVLDGPVISPAPGNHLLMNFVQQEIFIDEKFVGNVIGKDGKHINSVKESTGCSIIIQDPVEGSSERRLTIRGTFMASQAAIMLISNKIEIDRSNAERKRRSPL
Protein: alpha-glucosidase (EC 3.2.1.20) (Q9XVU3)
Organism: Caenorhabditis elegans
Interaction partners:
- Large neutral amino acids transporter small subunit 1
- Amino Acid Transporter
- Amino acid transporter
- 1,4-alpha-glucan branching enzyme
- Alpha-1,4 glucan phosphorylase
- phosphoglucomutase
- Peptide transporter family 1
- Bifunctional glyoxylate cycle protein
- Na
- Sodium-dependent transporter snf-5
Sequence:
MATKDALIAEEGTNFGGSSSGDIAVFDKTAEVVNFELEPKPIGLTKEQLEKYRNDPFWKPVRTILFVLFWLAWVLMFAGAIAIVVLSPKCAEKQKPDWWQTKVSYQLLTATFYDSDNDGVGDFAGISQKIDFLRKIGVTTVYPTPVIKIHKDEYFNSYDVVDHNSVDERFGTEEQFKELIDTVHNRAMYLVMDLPVSTIDLSHPWFESRDESKFVIAKPTDPGFNESNFYPFHGANNIKYLGYPSSQNPVLNWKNADVKSTINGAIQKFLDLGVDGFHIDHISQLAVDSKGRPNHDEAVKVLEELTKSVQIYVESRDELVDKKIVLFSSLKDVEDLHVKATETGLLHYVIDNSFANLDEKKCQPHVAKCVHDALNAAYQRHEVAKYTPHWQFSNSEASRLASRFESATAHLLSFLQLTLPGANSVYYGQEYGLKDAMSKNGEFKQMGVMQWYPAGKDHHGFSGNDAPIFFPESDDKLELDNYNTQFETENSALKIYRKLAKLRQRDEALIVGETVRDELINEDVILFSRYVQAVNNTATGSTFIVALNFGDKEQKIDFSIEPASKLIPSNKDLLNAEISVVTANVTDYRVRDHHNFVESPLVLPPKQAVLLKL
Protein: Coenzyme A biosynthesis protein 3 (P36076)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Phosphopantothenoylcysteine decarboxylase subunit VHS3
- Phosphopantothenoylcysteine decarboxylase subunit SIS2
- Phosphopantetheine adenylyltransferase
- Phosphopantothenate--cysteine ligase CAB2
- Dephospho-CoA kinase CAB5
- Pantothenate kinase CAB1
- Serine/threonine-protein phosphatase PP-Z1
- Casein kinase II subunit alpha
- Casein kinase II subunit alpha'
- Casein kinase II subunit beta'
Sequence:
MTDEKVNSDQNMNGKQGVNLISSLPTTQVPVSILTNKERRKSIHDESNFERSDSHEDQSKSNSNRRNIYKNDYSTNLRDFSFANLKQNSERNKDGHEIQINTSMPANTNGQQKRFSPSLPSAVSFTVPEVERLPYHRYSISNKPGKQQQQQEQLQQNQQQEEQQKAQLQEQNQRAKQQEEVKQIQEQVQKKQTERQQLIDEKERIANAIFKENTTNDGTDIRKHSVSSGTSNSEDEVDSPSMEKNSIVHMPGDFIYFNPKSNASKPITAKAAPLSANNSTHKNKEVITAPTGPRVPFTEFFQKEDDKKFHILIGATGSVATIKVPLIIDKLFKIYGPEKISIQLIVTKPAEHFLKGLKMSTHVKIWREEDAWVFDAVNKNDTSLSLNLILHHELRKWADIFLIAPLSANTLAKLANGICNNLLTSVMRDWSPLTPVLIAPAMNTFMYINPMTKKHLTSLVQDYPFIQVLKPVEKVLICGDIGMGGMREWTDIVEIVRRRINEIRKARDEETGDKEQEQEEQEGADNEDDDDEDDEEDEEDEEEEEALNETASDESNDEEDEEDEEDVKTEV
Protein: C4-dicarboxylate transport transcriptional regulatory protein DctD (Q9HU19)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA.
Interaction partners:
- C4-dicarboxylate transport sensor protein DctB
- C4-dicarboxylate transport sensor protein DctB
- MifR
- RNA polymerase sigma-54 factor
- C4-dicarboxylate transport sensor protein DctB
- C4-dicarboxylate transport protein 2
- histidine kinase
- Probable MFS dicarboxylate transporter
Sequence:
MSPFAPFDAQTQVLLIDDDPHLRQALRQTLDLAGLKVATLDDARQLDTAQCKDWPGVVVSDIRMPGIDGMELLRQLHEQDADLPVILITGHGDVPLAVQAMRGGAYDFLEKPFPSDALLDSVRRALEVRRLVLENRTLRLALAERHELHGRLIGRSAGMQRLREQVGSLAAIQADVLVLGETGAGKEVVARALHDLSSRRDGPFVAINAGALAESVVESELFGHEAGAFTGAQKRRIGKFEYANGGTLFLDEIESMSLDVQVKLLRLLQERVVERLGSNQLIPLDIRIIAATKEDLRQAADQGRFRADLYYRLNVASLRIPPLRERGEDIPLLFRHFAEAGAMRHGLTPRELDAGQSARLLAYDWPGNVRELQNAAERFALGLGLSLDDGVLPDAADEPHNLSAKVEAFERSLIAAELERPHNSLRSVAEALGIPRKTLHDKLRKHGLPFNTPGENPPDDGE
Protein: Chondroitin sulfate ABC exolyase (EC 4.2.2.21) (Chondroitin ABC exoeliminase) (Chondroitin ABC lyase II) (Chondroitin sulfate ABC lyase II) (ChS ABC lyase II) (Chondroitinase ABC II) (cABC II) (Exochondroitinase ABC) (Q8A2I1)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Function: Broad-specificity glycosaminoglycan lyase, which acts in an exolytic fashion degrading chondroitin sulfates and dermatan sulfate to yield only disaccharide products. Has a preference for chondroitin 4-sulfate over chondroitin 6-sulfate. Has extremely low activity against hyaluronic acid. Is not active against acharan sulfate, heparin or heparan sulfate.
Subcellular location: Periplasm {ECO:0000269|PubMed:6782076}.
Interaction partners:
- Endo-4-O-sulfatase
- Oligosaccharide lyase
- SusD homolog
- YjbH domain-containing protein
- DUF4836 family protein
Sequence:
MLILSFLCPAFLNAQIVTDERMFSFEEPQLPACITGVQSQLGISGAHYKDGKHSLEWTFEPNGKLELRKDLKFEKKDPTGKDLYLSAFIVWIYNEQPQDAAIEFEFLKDGRKCASFPFGINFKGWRAAWVCYERDMQGTPEEGMNELRIVAPNAKGRLFIDHLITATKVDARQQTADLQVPFVNAGTTNHWLVLYKHSLLKPDIELTPVSDRQRQEMKLLEKRFRDMIYTKGKVTEKEAETIRKKYDLYQITYKDGQVSGVPIFMVRASEAYERMIPDWDKDMLTKMGIEMRAYFDLMKRIAVAYNNSEAGSPVREEMKRKFLAMYDHITDQGVAYGSCWGNIHHYGYSVRGLYPAYFLMKDVLREEGKLLEAERTLRWYAITNEVYPKPEGNGIDMDSFNTQTTGRIASILMMEDTPEKLQYLKSFSRWIDYGCRPAPGLAGSFKVDGGAFHHRNNYPAYAVGGLDGATNMIYLFSRTSLAVSELAHRTVKDVLLAMRFYCNKLNFPLSMSGRHPDGQGKLVPMHYAMMAIAGTPDGKGDFDKEMASAYLRLVSSDSSSAEQAPEYMPKVSNAQERKIAKRLVENGFRAESDPQGNLSLGYGCVSVQRRENWSAVARGHSRYLWAAEHYLGHNLYGRYLAHGSLQILTAPPGQTVTPATSGWQQEGFDWNRIPGVTSIHLPLDLLKANVLNVDTFSGMEEMLYSDEAFAGGLSQGKMNGNFGMKLHEHDKYNGTHRARKSYHFIDGMIVCLGSDIENTNTDYPTETTIFQLAVTDKAAHDYWKNNAGEGKVWMDHLGTGYYVPVPARFEKNFPQYSRMQDTGKETKGDWVSLIIDHGKAPKAGSYEYAILPGTDRKTMTAFAKKPAYSVLQQDRNAHILESPSDRITSYVLFETPQSLLPGGLLQRTDTSCLVMVRKESADKVLLTVAQPDLALYRGPSDEAFDKDGKRMERSIYSRPWIDNESGEIPVTVTLKGRWKVAETPFCKVVSEDKKQTVLRFLCKDGASYEVELEK
Protein: Nucleoporin, putative (Q387F2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567}.
Interaction partners:
- Poly
- Protein transport protein Sec13, putative
- Uncharacterized protein
Sequence:
MSAGFGGGFGQPAATGFGQQPTGGFGQAPQGGAFGQVAPAATGFGQPSQSAVTGGFGQTNTGGFGQPAATGFGQPAQGAVTGGFGQTNTGGFGQPAATGFGQPAQSAVTGGFGQTNTGGFGQPAQGGFGQTAAAANAFGQAGPSGGFGQTNTGGFGQQSNSGFGQAGRGATAGFGQPGTGFGQPATGGFGQATSASPFGQAAAGRGVGGGFGTAAGTVGGFGQPAATGGFGQTATTGGFGQPAQGAAAGGFGQPATGGFGQATSASPFGQAAAGRGVGGGFGTAAGTVGGFGQPAAPGGFGQTATAGGFGQPARGAAAGGFGQPATGGFGQATSASPFGQAAAGRGVGGGFGTAAGTVGGFGQPAATGGFGQTATTGGFGQPAQGANTFGQGTPSAGGFGQAGRGVTGGFGQTGVTGGFGQTATTGGFGQPAQGAATGGFGQAGRGAADGFGRPAQGAAAGGFGQPATGGFGQATSASPFGQAAAGRGVGGGFGTAAGTVGGFGQPAAPGGFGQTATTGGFGQPGRGAAAGGFGQPATGGLGLAGGSGFGAAAGAGGFGQQSTASPWGGGATPAAPVDVSLLNLPEFADKPYGNVLLFAPEKPPKKPISVGHTPSPAAPFNPISVPRYQQRIPVGIPAPTVSANVKLQPTPFSTSALSSVELRELLNASKVNLGVSDDVQKIDSPKVSRVVAAGEKPPSHDAAVFAPVCSKEEYILDPPLATLQGLAVRQLQEVYGFSVYRRDGKCSVHFLEPVNLVRCDIAEIVELRPSGEVKLYPCVQNPPSIGQGLNVKARVTVNGVIGTTSNDLLIRCQKEGNRFESYDVNTGTWVYVMNVGDDGQNEYDDADREVDIVETDTQVQDGEQFPVANDIADGGVRAISQLDTCAQLKRSDPPSPPFLQQQQQVPVLHQNEAVSALSFSRYAPFDDQSLILPQRTQRVSVLRQAVHRPAADTTSGISDFELPYTLPSPKKTPLCERKGPLVVKEPYAKAHGPVYVVKREDSKMYEMNASVVSRGAMASLSRSFRCGWCTGGRLVAPMFAWVRDGTESRHSVDEVLGSRVVMSTVYFAHATSKHYLQSCAISVLRALCRHAHRVDASSDKEGFFPLLELGLCRDTGSTSLSTEKLREVIAAVDAVRFDGASAVGESTARQAKTILSLLDALYGLPDADEADKNAITERRYLTQLRRRNLNSWLKTELEYMDLWTDLDVDANPSQKLLRKLLCGKLREASSVAKALGSTELSRVVGICGEGNHFGSYVQTSDNSCIDEALGIRERVVSLLSGIVEPFVSQPQYAWAEDEKGGRTVAKVPLAATWKQLLGVFAFYGCTPDSSAEETIDCFLKRLRAPTSRRENSFPPYAERISADKLGTGRGRSFVSLGEWFPDAALSLLEGFAMGVAPAATALHPHSSSYCATDYLTPFIIIVSVRALKLQRTDTYDDAETKALLGFAAALECLSDAWFWALLPLHMIVDDKCRAVAVEQCLRRNAHRFQGGACRTNTDYVHLAELLKINARLLDVEMLLEKVPADAPVNAPSIRTHSSLQEALHRFSRGFTKR