wanglab/gogpt-training-data huggingface dataset:
Protein: B lymphocyte-induced maturation protein 1 homolog (Q93560)
Organism: Caenorhabditis elegans
Function: Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip morphogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:24968003}. Cytoplasm {ECO:0000269|PubMed:21408209}. Note=Localizes to the nucleus and cytoplasm in hyp8-11 tail tip cells throughout development, but cytoplasmic localization is most prominent during male tail tip retraction. {ECO:0000269|PubMed:21408209}.
Interaction partners:
- F-box protein dre-1
- Transcription factor elt-3
- Zinc finger BED domain-containing protein 3
- Nuclear hormone receptor family member nhr-6
- Zinc finger transcription factor pqm-1
Sequence:
MGQGSGDDGVPPAPFSSAAAAAHSPPHSPLSVGVSSASSATSSSSTPPSSTSPAGVSASGARNVETDWKQSGDENLAELCIFHVPDKSVSLPNPKRAECTLPMNLILKSSSKNRKKSSIWSSDHIPRGVRFGPLVGEIRLVDVDTALVCPAEASMAGGGPAQEDVPFDEAPEEWKIYSPSGGRLNKTICVKDDARSNWMKYVAAAEEEDFQNLVAAQIGNDIYFYTVKKIEANTELSFWFSRDYARKLNYSTRPYVRVRRPATQLIPSAPPASASTAIASLAETIVAIDYSVKKLIESPIDTLSTDASSASDEEMIDVEEQESCTRPVAEVTRPNVIQNPVVRPVATKVNNFPGIPVRLGNFYASPLVDFKEFMRKSLQLKLVDTSMFVSPVAQTTAAITATGGRSGQPIDVQPVLAATAGAHFGNYAAIYGSQDFQHELSKPLYTSASPAFGGGGGMGGGFGMGGSAHTSSFHQLPFVNHSSSSHNDSSFNGVPNYVQQQENGKTRYACKDCNKTFGQLSNLKVHVRTHTGERPFKCEICTKEFTQLAHLQKHHLVHTGERPHRCDICDKRFSSTSNLKTHLRLHNGQKPYTCDVCDAKFTQYVHLRLHKRLHANERPYSCGTCGKKYISPSGLRTHWKTTTCKEEDMKDSMRDDLMDIKGEIDEGSMSGSGYGNLGIFENTLNSELKRPLMPIETIYSKYNLPNASLLGQGPSGMQEQQAPPPTSQQQQHMMYGNTMGHMGQGSHLQGPPPPPQHFQMDHSGMQNGGGIPHQHQLIQGGPSSGSGQQQHPQHNGIHRLPDLKNPLLPSLGLPHYP
Protein: UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosamine diphosphatase) (Q9I2V0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Can functionally complement lpxH deficiency in E.coli.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00575}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00575}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_00575}.
Interaction partners:
- Lipid-A-disaccharide synthase
- UDP-3-O-acylglucosamine N-acyltransferase
- UDP-3-O-acyl-N-acetylglucosamine deacetylase
- Tetraacyldisaccharide 4'-kinase
- 3-deoxy-D-manno-octulosonic acid transferase
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- Lipid A biosynthesis acyltransferase
- Peptidyl-prolyl cis-trans isomerase
- LPS-assembly protein LptD
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Sequence:
MSVLFISDLHLEAERPDITRAFLSFLDERARRAEALYILGDFFEAWIGDDGMDAFQRSIAQSLRQVADGGTRIYLMHGNRDFLIGKAFCREAGCTLLPDPSVIDLYGEPVLLMHGDSLCTRDEAYMRLRRWLRNPLTLWVLRHLPLATRHKLARKLRKESRAQTRMKAVDIIDVTPEEVPRVMRGHGVRTLIHGHTHRPAEHPLDIDGQPARRIVLGDWDRQGWALEIDANGHRQAPFPL
Protein: Variant surface glycoprotein (VSG), putative (Q580P1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MFLRTVVVELLFLGHWRHAEATHAALDEEKIKTLCKIANQLTLTPAIVVSKANQIKKTQEAAQEASQLAQAAAAATSDVNTSTVFQATALQAANCAETAATQYTKLINDAQEVMLNGPKTAGHITEIAHLLLKLSGDNSKWCLGTSSTKTTHTTVAQLGCPGIYVDTPPAATATDPTLVTQTGFFGLAGAANVESSTGYTKCYLLKSGASTIWGKAGPINVKLAADFLGLTAQDSHGSETANLETLNAGATNGKFNPASTGPQKLFNAIHRLNNFELQNCGKTTEEALQLAAADPTTQTLLAQALAARNSYEQANQATSDAQHMLKAAADGKADEIGKKVMENIKQTSTARIENTKQTSKQLKETPTAEQRRQSILLEHMNQRYQILQLSTDLEGEKIKRNAATSKAKLSDDDCKAKTGGACKDGCKEISENGQKKCVVDKKEATKVEGGEKDNKTGTTNITGSNSFVINKAPLWLAVLLLE
Protein: Transcription factor MYB16 (Myb-related protein 16) (AtMYB16) (Protein MIXTA homolog) (AtMIXTA) (Q9LXF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the control of epidermal cell morphogenesis in petals. Promotes unidirectional cell expansion once outgrowth has been initiated. Coordinately with WIN1/SHN1, participates in the regulation of cuticle biosynthesis and wax accumulation in reproductive organs and trichomes. Functions in cuticle nanoridge formation in petals and stamens, and in morphogenesis of petal conical cells and trichomes. Functions as a major regulator of cuticle formation in vegetative organs by regulating the cuticle biosynthesis genes CYP86A8/LCR and CER1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Ethylene-responsive transcription factor WIN1
- Homeobox-leucine zipper protein HDG1
- 3-ketoacyl-CoA synthase 6
- Very-long-chain aldehyde decarbonylase CER1
Sequence:
MGRSPCCDKLGLKKGPWTPEEDQKLLAYIEEHGHGSWRSLPEKAGLHRCGKSCRLRWTNYLRPDIKRGKFNLQEEQTIIQLHALLGNRWSAIATHLPKRTDNEIKNYWNTHLKKRLVKMGIDPVTHKPKNETPLSSLGLSKNAAILSHTAQWESARLEAEARLARESKLLHLQHYQTKTSSQPHHHHGFTHKSLLPNWTTKPHEDQQQLESPTSTVSFSEMKESIPAKIEFVGSSTGVTLMKEPEHDWINSTMHEFETTQMGEGIEEGFTGLLLGGDSIDRSFSGDKNETAGESSGGDCNYYEDNKNYLDSIFNFVDPSPSDSPMF
Protein: WD_REPEATS_REGION domain-containing protein (Q9XTS1)
Organism: Caenorhabditis elegans
Interaction partners:
- Meiotic spindle formation protein mei-1
- Meiotic spindle formation protein 2
- Katanin_con80 domain-containing protein
- Protein KATNIP homolog
- SH2 domain-containing protein
- PID domain-containing protein
- Coatomer WD associated region domain-containing protein
Sequence:
MKIEVVSALPHSTVHSAVLSRRHRSVICAGPYEVLPLEGCSEPLPSTSTLSELPIECLRLSTDERTIGAATNAILKVADIITGHEVRNLTGHTLPITSLAASKFNPYCWYTGSSDCDWTQWDTRMNPSKIFGSKTPGVVRSIALSPGDRYVAVGTDETIQIFDARQREFIKTFNCSGHALELHPSDVLLSSVGHDRIVRFFCLETFEMISQSDPFLDDIQASAFDTHVMIAATNDSINLLTWEPCCDILTTVPLKNVEKVVNVNANGLDLDFICIGDNTERLEMRTYAIEELLSYSPSHELCGSIYEEDEDVDNSPIDEVKALPELTELSNLPPRSPGLSCEETETSASPVNSSSSHSSPTSPVKPAPVKHRSASQKLPGKSTKTLNPKPAGSTRSVTPVSTKPPRTFGTAKSVIVSSKPSLSGYNNRANPSPSMSDLRTTKSMAGSTTSLLSERAPKKRSTSSRRNQEPITITYIGRPRTPSEGDVASTVSSSTSRNRRPSPSVAKKTSPPSIYAITSSPAKRASSTASGPTARRQNSTSSVTSTTSAKTPVGVWGACIETVHDIGIVAKKENRNIRRLKMLTSRRTSNVDIPPEVCSDEQLVLTATRILSRRNDWSLNSCHAYLPVIIDNIASVDVTNRAIALEGLAAIADTLGERLVKFASMNSHRIGVDVAAEERAEKAKACVQHLRSLVKKRDWYYKQLDEPSILKLDPILELLKKI
Protein: GDP-fucose protein O-fucosyltransferase 3 (EC 2.4.1.221) (Alpha-(1,3)-fucosyltransferase 10) (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10) (Q5F2L2)
Organism: Mus musculus (Mouse)
Function: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6P4F1}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVRFQRRKLLASCLCVTATVFLMVTLQVVVELGKFERKKLKDSNVQDGHRDVEGEPKHLEPFPEKEALALAGRTKVDAGSYPIVLWWSPLTGETGRLGQCGADACFFTINRTFQHHPMTRAFLFYGTDFNIDSLPLPREAHHDWALFHEESPKNNYKLFHKPVITLFNHTATFSRHSHLPLTTQYLEGVDVLKSLRYLVPLQAKNNLRQKLAPLVYVQSDCDPPSDRDSYVRELMAYIEVDSYGECLQNRDLPQQLKNPASMDADAFYRVIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPTIADWLPSNRSAILVSEFSHPRELASFIRRLDYDDGLYETYVEWKLKGKISNQRLLTALNEREWGVQDINQDNYIDSFECMVCRRVWANSRLQEQGLPPKQWKADVSHLHCPEPALFTFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKD
Protein: Serpin family H member 1 (E9PK86)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYD
Protein: Beta-glucuronidase (EC 3.2.1.31) (A3KMY8)
Organism: Bos taurus (Bovine)
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
- N-acetylglucosamine-6-sulfatase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- Hyaluronidase
- Hyaluronidase
- Hyaluronidase
- Hyaluronidase
- Hyaluronidase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
Sequence:
MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGFEQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRVVLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHTLPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQDIGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYLYSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSNVSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVTFVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSEYGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVRMIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
Protein: VQ motif-containing protein 1 (AtVQ1) (Q1G3U8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May modulate WRKY transcription factor activities.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9M9F0}.
Interaction partners:
- VQ motif-containing protein 19
- VQ motif-containing protein 9
- VQ motif-containing protein 29
- VQ motif-containing protein 13
- VQ motif-containing protein 20
- VQ motif-containing protein 8, chloroplastic
- VQ motif-containing protein 31
- Protein HAIKU1
- VQ motif-containing protein 22
- VQ motif-containing protein 11
Sequence:
MSAGVRSEPMKVVFINTQYVQTDARSFKTIVQELTGKNAVVADGPYEFSGQGYGGKDSSQRFCGVGKEAERGVETTEFDSFFREMPPVGELYNLWSDH
Protein: Type III secretion negative modulator of injection (Virulence determinant protein) (Yop targeting protein) (YopK (YopQ) homolog) (O68704)
Organism: Yersinia pestis
Interaction partners:
Sequence:
MFIKDTYNMRALCTALEQSAPDTIINTSKEENNSYYCATAHLLRTDVCSLVNRVGIEPLKSGSILSTLEELWQAVGIVYRLYEWQHVSDIDTNFKKLPNNSDFGLVFSVLDCDIEYVFIGKKDSEGNIEFYDPKNSLLIENDDIKKYLYDEDFHRFCIMLIISKSELEELSRESCDQECIMG
Protein: Retrotransposon hot spot (RHS) protein, putative (Q584N8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRANSPAAPQGNNANQQVADNFGAAVRRPRDENVPPPPAAAQPPQIRQRTEERPNWTMDSKVRNVLLEDYAGLRNMTLHDFLLKKFLNTYNTENVAMDVFVQSPRDYILDARILERIQRLDEFEEYKELYNQFSEMKRKARYLDEKEISTLSQWEEKGTVEIREFVGPVARGRLDAAVIAAKRAEKRAVLAADGSELRGLYDSICNAKWSYVMSGYDEEPLGLKVFDGRPPRMWTKEEVDVSHVPKTMNEPLPRHGNLEIAVLTSQVGWPYTSFEKNPNDYDINHKKGVGYVFNSDVYIRRETLRVWHKVKERLNQWLMGEVAINPMFHVVIGTPGIGKSFSVGSLLLYKLLHYEASQLQIIIYVVRGKAYVFHKPIGGRAGYVTFYSNYENAFTVVEQIVRDSSSGEDIKGYLIFDVDKDHHAPVKPPVGCAGIALSSPNVRQFHEWSKQNTASHIYINCDTLKDLEAIHISRWGKIAPAYGWSPPVAKEKIEREWQEIQGRILFVGPLLRHIGNLVSYDSQWTLIRGYINKLNDTYMNDYAEIFQNAAMWQTDKASHKLVRVVRVKEEELLSDTYRCRPLSSYTGQAILDFLRPWLLNKYAAMSALLSNRALTAHLFEKSGIEALSHEDTLIELARELQGLSFARNQIPQSVLQVLQEPRLIGPSIEVPEDVPIVAGAEIQYMKLYKPQSRSFPVVDAFFFVENQKTFVGLQFTISDKHPCSVGGLLKMKRYLRSYFQGWDNFSNDMVWEIIYVQRVDSEKITKPQPCSMTNREDGQDNEGEKRFWEQEVRQFSVSLSNHITALYVELKARGNNNNGVNNRGGNNA
Protein: NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.90) (Glyceraldehyde phosphate dehydrogenase (NAD(P))) (GAPN) (Q97U30)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Catalyzes the irreversible NAD(P)-dependent non-phosphorylating oxidation of glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3PG). It is highly specific for D-GAP.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
- Phosphoglycerate kinase
- Triosephosphate isomerase
- Uncharacterized aldolase SSO3226
- Fructose-1,6-bisphosphate aldolase/phosphatase
- Enolase
- 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase
- Pyruvate kinase
- Phosphoglycerate mutase, putative
Sequence:
MEKTSVLIKSKELMEIYELKDGVPYFKTYLSGQWISGDEWQDVISPIDLNIIGKIPKLNWNQIDDTLEHIYRKGRWSIRDTPGEKRLDIYKKMASLLDKFKEDFVNVLMINNGKTKSAAEGEVKAAIERLLRADLDVKETRGDYVPGDWSSETLETEAVVRKEPVGVVLSIVPFNYPLFDTVNKIVYTTVIGNAIIIKPPSSTPLPILMLAKVMELASFPKDSFAIITIPGRDMNKVVGDKRIQAISLTGSTETGEEVVRNAGIKQFIMELGGGDPAIVLSDADLAWAAQRIAAGIISYTGQRCDSVKLVLVEEEVYDTLKDLLIKELTKSVKVGDPRDPLTTVGPVIDVKTVDEWEKAIKDAVEKGGKILFGGKRLGPTYIEPVLIEAPKETLKDMYFYNKEVFASAALLIKVKNIDEALEISNSRKYGLDAAIFGKDINKIRKLQRFLEVGAIYINDYPRHGIGYFPFGGRKDSGIGREGIGYTIQYVTAYKSIVYNYKGKGIWEYL
Protein: Uncharacterized protein (Q585U5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGGVNPTVRLSATAGGGTGTAGNNEQAPQPSDASVSKPQPIMSRAARRRAKKPPVIVTPQMREDARERLRELRKYHRLLKSNGARRKLAKLRAQKRQRDVNPVDEVCARFDTDCRPRKKSRRE
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8I4Q9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MSLFIESSFILPKGIIDSYIKFKTWNSCSYSDKEKKASQANIWTPVFSTRFAIPIIGIIYALLWNGDATFGYSALDMSLDEKYSRTLFETNNGNNGYVSSLTNKILNNMNKGPKKEVEEKNAEKILGFDDKNILEALDLFINNIKNIALSSKLNSSDIYNHGNTFIDNVMSNEEIDQEIESFLNGGNYDREKLNRLWWQIMRNEELKYVSVNNKLYKVYKALRKKYNVDNSYAENKWNECKKNIIVGRVEYQNYINKVFLDWINGDSINNDEFIKLVRTCRVTWKKLRTKMIKALKKSLTKSFEKRHNELKSNEYIYKYKYELEEGDYADDDLLIKDDLLNNHDFQFDDDVSSVITEKTNECLKGDHDLESVNTDNHGTELEESDSSSGSKVSNETTNSGDSDDSKKTIVLNLEGQCTIYLRRRPKNLTLSSPQRLKFTAGGGFCGKLRN
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (C9JQV6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESIFHEKVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK
Protein: Sulfhydryl oxidase (EC 1.8.3.2) (Q38EW2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKQEPLQKIPGECPTPRELGKAGWIILHSAAAVFPYNPTPTQQEAFRNFLHGWSHAYACSHCAYHMRRYFHQNPPVVTDKLALNRYLCEFHNAVNERVGNKIYDCDPMNVLRRWHPTFPDMEDQPTIEEQVKSLELKEKNETPQGVSDRWRQQNSSASPDGNVGRWSVGDARWTDTTSESRRTNVGEISAGWGTAGEKMKQRNSAGDGVSDAGASEKKWWRWGNSTSSSTTATIATPSAAEPAEDVEASVTSILSKLRACMVYCPDDKKSSA
Protein: M-phase inducer phosphatase cdc-25.2 (EC 3.1.3.48) (Cell division cycle-related protein 25.2) (O44628)
Organism: Caenorhabditis elegans
Function: Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Plays a role in male tail development, via regulation of the cell divisions of the ray precursor cell lineages, perhaps acting together with cell cycle regulators cyl-1, cdk-1, cyb-3, and cyd-1.
Interaction partners:
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B1
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1
- G2/mitotic-specific cyclin-B3
- G2/mitotic-specific cyclin-A1
- Serine/threonine-protein kinase chk-1
- Cyclin-dependent kinase 2
- F-box/WD repeat-containing protein lin-23
- Serine/threonine-protein kinase plk-2
Sequence:
MNRPSQISQDVAQPLSNQHETAMMSSDEDSMSRDSGICELMDENTPVCFSSMSTESTTVQVEECMEIDEDENLQPGPVSRRQKKVTFRREKSSCQVRLFDESPTSHKMFMRPQAPLSVRSENQQLLQQRKRKFEKSEQSSDHFHLEPMSVEAMDDDEIVMMDQNTTKWEPGFRAPNHKKGRLTRSATAFPSLETFEEEEHEEQHHLNVKYHLKTVAKESSKGFRRITAETLRDIFFRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFYDENGRKRCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHYPKCDYEEMYVLDLGYRNFFFAANEANITNLCQPHAYCEMHDKEHTMELKKYNFHNKGQSVLRTVSMSRSFKSLPTGSAFNFVASSASFTSAPSTSTENIDTNDDCQKSRTPAVPRIASRRNLFSDPSHSPTNFAQFPLTCSRETPSPHKHPLTCPRFS
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8Y521)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRGVCGRPRPPPMGRSTRAVGPAHLPSLPPDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Protein: tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2) (Q8NBA8)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:31804502}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:31804502}. Cytoplasm {ECO:0000269|PubMed:31804502}. Note=Localizes mainly in the nucleus. {ECO:0000269|PubMed:31804502}.
Interaction partners:
- tRNA-uridine aminocarboxypropyltransferase 1
- 18S rRNA aminocarboxypropyltransferase
Sequence:
MESQKEARTLQEPVARPSGASSSQTPNDKERREGGAVPAAAALGAEADDDSADGLWELPVEPAERRPECTRCSRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLYPKPMPKNKRKLRKMELLMNSVKI
Protein: Signal transducer and activator of transcription (G8JLH9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
Protein: Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4) (Q8WX77)
Organism: Homo sapiens (Human)
Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
Subcellular location: Secreted {ECO:0000269|PubMed:15845387}.
Interaction partners:
Sequence:
MPRLSLLLPLLLLLLLPLLPPLSPSLGIRDVGGRRPKCGPCRPEGCPAPAPCPAPGISALDECGCCARCLGAEGASCGGRAGGRCGPGLVCASQAAGAAPEGTGLCVCAQRGTVCGSDGRSYPSVCALRLRARHTPRAHPGHLHKARDGPCEFAPVVVVPPRSVHNVTGAQVGLSCEVRAVPTPVITWRKVTKSPEGTQALEELPGDHVNIAVQVRGGPSDHEATAWILINPLRKEDEGVYQCHAANMVGEAESHSTVTVLDLSKYRSFHFPAPDDRM
Protein: E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186) (Q9NXI6)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction. Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23896122, ECO:0000269|PubMed:34623328}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA
Protein: Transmembrane protein (Q383R9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRRTSLRAIKPYLHAFSPGARASEKGMLYRNSNMNAHARVASIQQAQRTHREGKIFLMLLVPDQVFLSVVLVGVSLVAVLLYFRQQPFSFNTHKQRWILGAINEHEFYQRNREMSNVLAAHREAIEGTRDVIGDCPKVFEPPVGSHYISRSGDFAPRSD
Protein: 4-hydroxy-tetrahydrodipicolinate reductase (HTPA reductase) (EC 1.17.1.8) (P63895)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00102}.
Interaction partners:
Sequence:
MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQGIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL