wanglab/gogpt-training-data huggingface dataset:
Protein: Fibrinogen-like 2 (G3V7P2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Prothrombin
Sequence:
MRLPGWLWLSSAVLAACRAAEKHNLTEGLEDASAQAACPARLEGSGRCEGSQCPFQLTLPTLTLQLPQQFGSMEEVLKEVRTLQEAVDSLKKSCQDCKLQADEHPDPGGNGAETAEDNRVQELESQVNKLSSELKNAKEEIQGLQGRLESLQLVNMNNIENYVDNKVANLTSVVNSLDSKCFKCPSQEHNQPNPVQHLIYKDCSDYYVLGKRSSGTYRVTPDHRNSSFEVYCDMETTGGGWTVLQARLDGSTNFTRGWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYAVYDQFYVANEFLKYRLHLGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQRYKGVRNGIFWGTWPGVSQAHPGGYKFSFKKAKMMIRPKSFKP
Protein: Tubulin glycylase 3F (EC 6.3.2.-) (P0CAZ1)
Organism: Tetrahymena thermophila (strain SB210)
Function: Probable glycylase which modifies tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of tubulin.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}.
Interaction partners:
Sequence:
MSDRIYHSYVNNFYQKAKSPKNTQLIKQIQRSNPTSPKKNLQIYKNINPFNHENCQRIIEENAIRFSDKKTVQLGTVYGCNILLTTKNSQPKVFEKLIQLSDNSNFRQVTLLKSISPVSVVKAKDFLNDSISNRSRSAQKMYSDKDKFQVGNNKSSLRSLIYFPLANIKDQISEESKSKRNKIKVIKDMPIQLDNSFQTINHQINSPNNNIVGDQSHVILHNIFKKRQQAEEGLQIQEEPQNYIKNKLELQERKMYLENQNPKSLSPIKIHFNEKSMPFKNKIQKKITYNEQSSIQQTITLIKKKILGPPSLYSRLKKNSEQFKNIENLIKNKAKESHEQNMQEYLKRIGCTDKNKKVFCINSQDQFVQEVLIELGWIENKLFKSDLFHLKWIYTDINKDYENLKEGQFYNHFQNNQELTNKGRLLRNIKLYLVSYPHLQKYFPIQFDVIYKQQKEEFLNEFQKFEIFRKFKDVIQIIKNDLTQELINQLTQIYHTKFIKKEEEEELQYGLITYFRQNQQFKQYIEYINQVNKDIINLLSKIPNPNINEMLIKYLNDLSILQVDKLECDQEQGDKNIQAQIINLSISIELDNILEQIYPYTNFCNFWIIKPCGSSKGQGLQIMSDDNQIVNYTTQLQARLVQKYIERIYICKSQEYPQLYNKKFDLRLWVLVKSFNPLTVYYYKHAYLRVCSSEYDLSDTRNIFSHFTNYSINRNKFIQNKNVEDSAISLKLLKHIIKKEHGISYQKKIQPQINEIIIHSLKSVQKKIKQNNSCFEIYGFDIIFDEQFNPYLLEVNLSPACSKRNEFISKLQKEMFISTLNILFNTEYYQIQNWKKIKIQDQIQKVINESTHTQLQEEVILNSNNFQSEDSEERFISAAITIQKWYRQIKLMKNENQKI
Protein: Small ubiquitin-related modifier (Q8I444)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- SUMO-conjugating enzyme UBC9
- Ran-specific GTPase-activating protein 1, putative
- Sentrin-specific protease 1
- Sentrin-specific protease 2, putative
- SUMO-activating enzyme subunit
- Proliferating cell nuclear antigen 1
- Aspartyl protease
- SUMO-activating enzyme subunit 1
- Ubiquitin-like protein nedd8 homologue, putative
- Uncharacterized protein
Sequence:
MGDDDSAVNNNGSSPVNNQGEHIQVKVRSPDGAEVFFKIKRKTKLEKLMEVYCNRLGQSMEAVRFLYDGDRIHGDNTPEQLGIEDGDVIDAMVQQTGGSF
Protein: Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase) (P20794)
Organism: Homo sapiens (Human)
Function: Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. {ECO:0000250}.
Interaction partners:
- DNA replication licensing factor MCM3
- Cell division control protein 6 homolog
- DNA replication licensing factor MCM2
- Origin recognition complex subunit 4
- Origin recognition complex subunit 3
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM6
- Origin recognition complex subunit 2
- DNA replication factor Cdt1
- DNA replication licensing factor MCM5
Sequence:
MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKYGGHR
Protein: POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP) (Tst-1) (P20267)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P21952}.
Interaction partners:
Sequence:
MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQKLMHHEWLGAGAGHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGSTGRADDGGGGGGFHARLVHQGAAHAGAAWAQGGTAHHLGPAMSPSPGAGGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGSASPPSAPPPPPPAALHHHHHHTLPGSVQ
Protein: Transcription factor E2-alpha (Transcription factor 3) (X6REB3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGECLAWCGPSAVHRCADVGLGMVSARTAPGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVLSLEEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM
Protein: C4-dicarboxylate transport sensor protein DctB (EC 2.7.13.3) (Q9HU20)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity).
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- C4-dicarboxylate transport transcriptional regulatory protein DctD
- MifR
- C4-dicarboxylate transport sensor protein DctB
- Probable two-component response regulator
- Citrate-proton symporter
- C4-dicarboxylate transport protein 2
- Probable transcriptional regulator
Sequence:
MPRILAATAGSFVLKAYFHRWRSLVILALLLAPLLWPLQYFAERYYSEQLAEQNRQTLDLYVANLLGTLRRYEELPQILGGLPVLRQALQQPGDPLLQKIANEALADIRRRTGADVIYLLQPDGTTQVASNWAQADSFVHRNFAFRPYYREAMQGRLARFFGLGTTSIKRGYYFASAVKEGSRIIGVLVVKVDLEHIERLWGNSPEQLLVIDNYGVVILSSREDWRFHASRPLSAAERDEIHANIPYPVQDPKPLRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEERVLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMVASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKAPPRRLWVIASQDQHGVTLTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHLLPGVPGVAAMPQEETRA
Protein: Glycine N-acyltransferase-like protein Keg1 (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase protein Keg1) (Hepatocellular carcinoma-enriched protein of 33 kDa) (HP33) (Kidney-expressed gene 1 protein) (Q9Z2Y0)
Organism: Rattus norvegicus (Rat)
Function: Acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10194414}. Note=Also localizes in regions surrounding the centrosome. The centrosomal localization is dependent on microtubules.
Interaction partners:
- Coagulation factor XIII B chain
Sequence:
MFYIQSSEALQILKNSLRKHLPESLKVYGTVFHMNQGNPFKLKAVVDKWPDFNTVVIRPQEQDMTDDLDHYNNTYLIYSKDPKHCQEFLGSSDVINWKQHLQIQSSQADLGKVIENLGATNLGKVKHKQCFLYMVSHTAKKLTPSLVDAKHLVVSSEKPTPFDHQLFKFARLDVKHAALVNSIWYFGGNEKSQKFIERCIFTFPSVCIMGPEGTPVSWALMDHTGELRMAGTLPKYRHQNLIYHVAFHQVHTLEKLGFPMYLHVDKVNLTIQRMSAVLGHVPMPCTWNQWNWVPL
Protein: Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Q8BLK9)
Organism: Mus musculus (Mouse)
Function: May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. Plays a role in the recruitment of PRDX3 to early endosomes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96S38}. Membrane {ECO:0000250|UniProtKB:Q96S38}. Early endosome {ECO:0000250|UniProtKB:Q96S38}.
Interaction partners:
Sequence:
MTSPWGHSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAYPDSPANAFPECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRTFGLSLSTDSSAVGAVASDSEPSRVEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRAAPQLHTGPQPPGSLSSRPPWSLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQRAEGGKLWSYISKFLNRSSQESLDIKEGRPSMPPRVCLQQPSASPQGGSSFESRGSDTGSMLKALPLKTSLTPSSQDDSNQEDDGQPSSPKWLDSGSSSEDECTAGYLTLCNEYGQEKMDLVSLSEESVMQPEGDKADTQAVSSPASLATGSVSPSTHLRVFSGGEDLEAVSSPPTSESLSRSKNSPMEFFRIDSKDSTSELLGLDFGEKLHSLKPEPLKALFTLEDGDSPSQSLDPGESKRESEAQDSVSRGSDDSVPVISFKEAAAEAISGAEEGRPDLLVNLPGELQPTKEASAMDPKFSQASAGRLDSKLLEAPDVLCLRLSSEQCHGLGPEGPEELSDPTEFCPGGVIPEHDAQADPGVLFEAAVDHRSSPDQFLFSSLRSESDRLGQVEVVVTAQALQESLFHISSPCSGANKEHSAYADTATSEEVLLFTEPTKEEANSLFQRGSEAQERGVGAGEADKEIHQIFEDLDKRLAASSRFFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDSCDSDAVARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR
Protein: Peroxisomal biogenesis factor 8 (Peroxin-8) (Peroxisomal protein PER3) (Q01962)
Organism: Komagataella pastoris (Yeast) (Pichia pastoris)
Function: Essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:7738036}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MYRLGSQGRSIQSQLQNGDSSSGRPLQLQGTGMREAQRIPQQLDYLLAEIISPNEDTNVIGYLAYYYPKLKNEQNVALLTDFFLRCPTYFSHSNVVSLRNNYPVMEAFNYIMTTKFKVSQPTVPFYRFYAAVLASLLNCEKTDPSHHWKLIPILTGVLLSIKGRDDVELYPDHSRSIKGSDTAVAQLLQRCLLRFYQSGDARSYDLNALVIISMSCALDYVEDDTIKKILYCFNYTRAIIDLIYYSPYGLNDSDIPLLSDSSVNSQSFDQLLNNNPALKHLNRLSFLFERTVKLNDGSIQSNLNDIDISLNKMQSFSEKLSKKISVLDDDSSKGVGQLLRQCLYASIIIHQAILTTFFQLDNADYTKYFLPSFSRKILSILFNLFFIVDRIGTGGFQPYNFVYLTCLQGIIQYDMKTAESLVKTFTTGINYSSLKDSEVARAKLLFTLNLMEQIVNICSDDLRLELIVPLVEDLVNNKNACVDIHNHVFKSIFESAHSVILKFFTVVDSSVKNVDYETNVTLVSEKIIPYLTLVIDQFPEFLSINQLDIAIETISRTVFPDSPIYSYDKNISSMFLNVLFNKCLTVDNDELVELPAIEAVVAPKNDEENNTSDAQDGGPKELQSLNDLKSRRSALISALISVFPLIPVKDYTKWLSIAFYDLIVATPERTERAFLQERLWDCVVGTNKYDPQKGNLGIMWWYENVNAQSTAKL
Protein: YopK (Q56935)
Organism: Yersinia pseudotuberculosis
Interaction partners:
Sequence:
MFIKDTYNMRALCTALEQSAPDTIINTSKEENNSYYCATAHLLRTDVCSLVNRVGIEPLKSGSILSTLEELWQAVGIVYRLYEWQHVSDIDTNFKKLPNNSDFGLVFSVLDCDIEYVFIGKKDSEGNIEFYDPKNSLLIENDDIKKYLYDENFHRFCIMLIISKSELEELSRESCDQECIMG
Protein: Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) (Q3KR16)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Subcellular location: Cell projection, microvillus {ECO:0000269|PubMed:17881735}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16721066}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16721066}. Cleavage furrow {ECO:0000269|PubMed:16721066}. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow (PubMed:16721066). In epithelial cells, recruited to the apical membrane by EZR where it participates in macropinocytosis (PubMed:17881735). {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
Interaction partners:
- Transforming protein RhoA
- Rho-related GTP-binding protein RhoG
Sequence:
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
Protein: Uncharacterized GTP-binding protein P8A3.05 (Q9UT10)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exosome complex exonuclease dis3
- Exosome complex component rrp43
- Protein dom34
- Exosome complex component csl4
- Putative ATP-dependent RNA helicase C550.03c
- Exosome complex component ski6
- Exosome complex component rrp46
- Exosome complex component rrp42
- Exosome complex component rrp45
- Superkiller protein 3
Sequence:
MSRLSQLLNSKKAKQKPPSEHPIGLSSILKQDSSSSSDSPNFFPSSSTNDHQERDTINDTNFVVPEKQKTSKLALLAAERKKLHSSFPSTQQQPPKTEKEKEKEPIQAKHKKNVENDFLLQRFRKVRIAEKKDSEQPSSHEIHLTDDDDKTTLQKQMVESDQLKKNPQEVKLAPPSSFAKCLTGAKKRVFEDQIEIHLSKSSLLGFNAPSPDDIVLMAQSKSKSFQKHKRLDEQLLNSVKSMKKVSQQLKPQKNTNDSNNDHTLLSQDQLIELSKLVKPRTKLLLLGPPKSGKKTLLSRLFFQIGSFDPKTMQKCTVLNAKKESLSSVLKSTKTKWYDFETFSNSYSSTIIDFPLGIFTTNASSRDNFLKHSSLFQVMNTAIFTIDCLNPLEGLDGISSILQLMNGLSISSYMFAITKMDEIEWDENKFINLVNSIQSFLKESCGIIEKSKFIPISGLKGTNLTSISQEKLSQWYKSDTLLGKIDKEADTNHGTWNFLLNLPLSLTISHITPLPENQSHIYCSIHSGMLQDSQKLYVGTGRLETQITGLSSDENPKGFNVAGDMIQAKIPTLPNLCPGILIADSIDAFTSSKTAYVNATWFHGSLEKGKSMHVIALFGCHAVLTKLYCFTDSQEKAPNAIGNDLERNRTSLVKIELENAFPLVKESYINTLSRVLFVSEKWNSLIAFGTVLSLHD
Protein: IQ domain-containing protein IQM4 (IQ motif-containing protein 4) (O64851)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in biotic and abiotic stress responses.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O82645}. Nucleus {ECO:0000250|UniProtKB:O82645}.
Interaction partners:
- Chloroplastic calcium uniporter protein
- Armadillo repeat only 1
Sequence:
MGLSLSLLLSAWKEVVTTQFFSFKNPVESFLETRSFSLKLKEGGLTSRTNSFKSENPQEKSPKTGMERSLSFNSWEIVTEVETEPMNKEDEEIVEPTKPARNSLNGRNCERIQITKPTITPPTPFVFFSPRPVTELDAAATTLQKVYKSYRTRRNLADCAVVVEELWWKTLDAAALNLSSVAFFEEEKHETAVSKWARARTRAAKVGKGLSKDEKAQKLALQHWLEAIDPRHRYGHNLHFYYDVWSASMSAQPFFYWLDIGDGKDVNLEHHPRSVLQKQCIKYLGPLEREAYEVIVEDGKLMNKQSMTLINSTEDSKSIFVLSTTRTLYVGQKKKGRFQHSSFLSGGATTAAGRLVAREGILEAIWPYSGHYLPTEDNFNEFISFLEENNVDMTNVKRCSVNEEYSSFNSSGYEEEATKEEEAEKKPAETIVTEEQEEEKERERPVFQLAKRLSCKWNSGVGPRIGCVRDYPMELQSQAFEQVSLSPRISPGSTRFPSPYGPIPSPRPSPRVRVSPRLAYMGIPSPRVQVNC
Protein: Ribulose bisphosphate carboxylase small subunit (RuBisCO small subunit) (Q44178)
Organism: Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00859}.
Interaction partners:
- Ribulose bisphosphate carboxylase large chain
- Carboxysome assembly protein CcmM
- Phosphoribulokinase
- RuBisCO chaperone RbcX
- Phosphoribulokinase
- Phosphoglycerate kinase
- Haloacid dehalogenase-like hydrolase domain protein
- Putative haloacid dehalogenase-like hydrolase
- Glycerate kinase
- Carboxysome shell protein CcmK
Sequence:
MKTLPKEKRYETLSYLPPLSDQQIARQVQYMMDQGYIPGIEFEKDPTPELHHWTLWKLPLFNASSAQEVLNEVRECRSEYSDCYIRVVGFDNIKQCQTVSFIVYKPNQTRY
Protein: glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39) (Q9UVV0)
Organism: Aspergillus fumigatus (Neosartorya fumigata)
Interaction partners:
Sequence:
MGIVSFLKPVVLANGQDVFVPVSTGPNSQDDWLEERSSVNTDTPVETNKFYCGLFLGTQTNNTFTHPYSVAWVKGGGTSQSYGMAISHVESNIVAHGPVNTAIPGSPISYYVNPIGIHSVILSASELGPSTVLTTENPLPFSANAVLRPSASSSQSITIPVVQGMGFVTGIYSNLQPKIQSGVFFTKMVTAGSPRTGIFKYSLSLEDGTSWLLYATPDDGSDPQLQLASNSEIIGPAGWSGTIQVAKNPAGASGEKFYDNSSGVYAVEGAVMGSVSESTGTYSLMWAKAGKDAQNTPLLMFALPHHMESFDASTQSRATNITLRTTTKGQATAVIGEYWTMVEPELPISMGFAPWSVSGGSIDKISPAAQQVILAAAPTELQQDMDAQTNLNSMYFSGKALSKFATLLYTVDKLGGNSTLAAEGLARLKQSFARFIDNRQQFPLVYDNVWKGVVSSASYATGDVGADFGNTLYNDHHFHYGYFIHAAAIIGSMDPQWLETSKDWVNMLVRDAGNSAGNDPLFPFSRGFDWFHGHSWAKGLFESFDGKDEESTSEDAMFAYALKMWGKTIGDVSMEARGNLMLGILRRSMRNYFLMESNNKNHPANFIANKVTGILFENKVDHTTYFGNNLEYIQGIHMLPILPCSAFTRSKQFVKEEWDAMFASNGPDPAENVVGGWKGVLYANLALVDPAASWNFFTQPNFDYSWIDGGASRTWYLAYAAGEFIID
Protein: Protein BOLA1, chloroplastic (Q682I1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act either alone or in interaction with glutaredoxin as a redox-regulated transcriptional regulator, or as a factor regulating Fe-S cluster biogenesis (Probable). The glutaredoxin-BOLA1 heterodimers bind a labile, oxygen sensitive iron-sulfur cluster.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:24203231}.
Interaction partners:
- Protein BOLA2
- Monothiol glutaredoxin-S14, chloroplastic
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- Monothiol glutaredoxin-S17
- Anamorsin homolog
- Monothiol glutaredoxin-S15, mitochondrial
- NifU-like protein 5, mitochondrial
- NifU-like protein 1, chloroplastic
- Lipoyl synthase, chloroplastic
- Lipoyl synthase, mitochondrial
Sequence:
MFSSSIRLIVSGFHRTQPLKSPVNSPSVFISVPKFFNSESKSTGTGSRSVAMSSVEKTGSDSGAIENRASRMREKLQKELEPVELVIEDVSYQHAGHAGMKGRTDDETHFNVKIVSKGFEGMNLVKRHRLVYHLLREELDTGLHALSIVSKTPSESPSKD
Protein: Small glutamine-rich tetratricopeptide repeat-containing protein 2 (O13797)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Co-chaperone that binds to the molecular chaperone Hsp70 and regulates Hsp70 ATPase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Golgi to ER traffic protein 4
- ATPase get3
- Protein get1
- UV excision repair protein rhp23
- UPF0303 protein P4H10.12
- Heat shock protein 104
- Heat shock protein 90 homolog
- Heat shock protein homolog pss1
- Protein transport protein sec61 subunit beta
Sequence:
MSSNKVTAAIIDYLKQAITTGSISEEEKESLEVAAQCIQDSFKIKPEEIKPKSGDRLVAAFEEYEKLHPVEEDSTAHVNKEEAEKLKLEGNNAIAAKDYQKALDLYTKAIEIDPTSPVYYSNRAAAYNQLGQFENAVEDALTCLSLDPHHARAFGRLGRAKLSLGDAAAAADAYKKGLDFDPNNEVLKRGLEAANKQLNQPSDSSATSGADQARTSAGAAPDLGSIFGGGMPDLGSLMNNPAVMNMARNLMQSGALNNIMNDPNIANMARNFQSGGGMPDLSSLANNPQLQNLARNFMNNNNNGNTDNNNQGNPPPQ
Protein: Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19) (Q9EQ14)
Organism: Mus musculus (Mouse)
Function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular location: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
Interaction partners:
- Interleukin-12 subunit beta
- Interleukin-23 receptor
- Interleukin-12 receptor subunit beta-1
- Non-receptor tyrosine-protein kinase TYK2
- Tyrosine-protein kinase JAK2
- Interleukin-12 subunit alpha
- Interleukin-12 receptor subunit beta-2
- Interleukin-27 subunit beta
- Interleukin-17F
- Interleukin-17A
Sequence:
MLDCRAVIMLWLLPWVTQGLAVPRSSSPDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDSDIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA
Protein: Tegument protein VP22 (G3G8W7)
Organism: Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Subcellular location: Host Golgi apparatus {ECO:0000256|ARBA:ARBA00004136}. Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Virion tegument {ECO:0000256|ARBA:ARBA00004535}.
Interaction partners:
Sequence:
MSSSRKTRVAADETASGARRRAGSASRTRTTAPAAATPRRPSAYDDYDDGFSYRSAPSYDDDGYYGYDGYGSSRAPRAAKVTPAAASRASTGAKSASAAKTPASAAKTARSAPAAAPAATTTTTTTAAAEPAARRASTRAAPGENLDVGRRRLAFSDRPCEANVPWRGATHAFNKRIFCAAVGRVAEAHARAAAESLWDMNPPTTDAALDRFLQAAVVRITVCEGLDLIEAANAVLDESTPGRKGKVYK
Protein: Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1) (Q9Y5R6)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- Transcription factor SOX-9
- Sex-determining region Y protein
- KN motif and ankyrin repeat domain-containing protein 1
- Transcription factor GATA-4
- Transcription factor SOX-3
- Muellerian-inhibiting factor
- Dedicator of cytokinesis protein 8
- Steroidogenic factor 1
- Forkhead box protein L2
- Desert hedgehog protein
Sequence:
MPNDEAFSKPSTPSEAPHAPGVPPQGRAGGFGKASGALVGAASGSSAGGSSRGGGSGSGASDLGAGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENNGSNPCLMTECSGTSQPPPASVPTTAASEGRMVIQDIPAVTSRGHVENTPDLVSDSTYYSSFYQPSLFPYYNNLYNCPQYSMALAADSASGEVGNPLGGSPVKNSLRGLPGPYVPGQTGNQWQMKNMENRHAMSSQYRMHSYYPPPSYLGQSVPQFFTFEDAPSYPEARASVFSPPSSQDSGLVSLSSSSPISNKSTKAVLECEPASEPSSFTVTPVIEEDE