wanglab/gogpt-training-data huggingface dataset:
Protein: GDNF family receptor alpha-2 (A0A8I6B3J9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MVVGEYGQPGWVCVDLGLGVLLCKVGEKFLQTLGLHWGQRLWWPSFMLVFPSHYPDETLRSLASPSSLQGSELHGWRPQVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGTDPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYRTITSCPADNYQACLGSYAGMIGFDMTPNYVDSNPTGIVVSPWCNCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNMSPKGPSLPATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSIQEQGLKANNSKELSMCFTELTTNISPGSKKVIKLNSGSSRARLSAALTALPLLMLTLAL
Protein: LD40493p (Mitochondrial transcription factor A) (Q9VDL2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIYTTTLMSSRGGLIGSLINKVRPLAAASISNTPAVPSKTLEEQLGLPPRPKKPLTPYFRFMREQRPKLKAANPQITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQQIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRFIASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVYMQESRKEMELYRKAISVWEEKMIRLGHIDVVRHGNLIDPPEPKPRKTLASKDI
Protein: Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) (O43511)
Organism: Homo sapiens (Human)
Function: Sodium-independent transporter of chloride and iodide. Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry. Mediates electroneutral iodide-bicarbonate exchange (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11932316, ECO:0000269|PubMed:24051746}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11274445, ECO:0000269|PubMed:35601831}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Gap junction beta-2 protein
- Forkhead box protein I1
- ATP-sensitive inward rectifier potassium channel 10
- Sodium/iodide cotransporter
- Iodotyrosine deiodinase 1
- Otoferlin
- Thyroglobulin
- Thyroid peroxidase
- Dual oxidase maturation factor 2
- Unconventional myosin-XV
Sequence:
MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (A0A8I5ZXX6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTFNDPSLLENLQNNHPTAPIICEFLTMMAVCHTAVPERDGEKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSSRKRMSVVVRTPSGKLRLYCKGADTVIYERLAESSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLRRNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAVPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW
Protein: Uncharacterized protein (Q388S3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVGKVFCRDVYPLMTVSQRAHLWALRNQALFGDAPDECIEGSAQQSSMGENQVGRAPNALTMSVDGQIVPLTKPRWYEFTKCLYYKTWVGLRGTISLQVAAETFCSEFFYLLKLYPAPSMLPVMDAVLRTANARAAVVEAASKKTSMKSITPKNGFYLRGCYDDPAAIAFLWLCRAYCIPCEAELQPISANHTLRDRYPFYVKSVETNTVVAEPLAAFSLCVELYLPNSEHWFGVLPGTGSGTPLGTRAAQKSMWLEYMQFVLSELREPLLRFIRGECEEDGYVDVLERGNPLLQRYQKDRVKLPLGSSRRSKGRNKLLKRMNTGLARYERFARHYYATHPCSVVSVAELFVAAYAYVVCANPLCDDVIPLQEAVPSSTGRADAQIPSRWSRQGSYYSAKGGIDSMPAQVSRSNVLISGVSKECQEVAALILNGASNEQSKSLIGSHVSEIVENSKQVVGEKLSNAAMNFLGRHQPWINVECRTNMLATEVIDSFIRNRCRPLQPKLGELLSHVWCMANEQCEGFPFIVLNRDLRNFVTTLTGHTSSMLQEITSRGYGGAVSTIAQVYWEKLREVFNRAPTSSESRMYHNYTSKM
Protein: Adenosine transporter 2, putative (Q586M7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAMLGFESTAEFFVYLTFIFFGMSVMNVTNAIYSIPDYFSVYYQFVKNDEKAKPVNASFWEHMFTYYNVVVFTMQVVLEAFMLTPLGRRIPISWRLIFGLTIPMGEIIAILVIPEVGGSEAGAMATVMIVAFVGGISKTLCDSSNAALAGPFPTKFYGAIVWGLAVSGLITSFMSVVIKAAMEYSFKSRRVQSQIYFGLVMLLQVVACVLLVLLRKNPYAIKYAAEFRYAARKDGKTDDGEDENDAKGTGPADEDGYPDEKENKNVLNADIDPDKMKDTDQVEGTTNAQQMLDASVMVVVKRIWPMLLSCFFVFFATLLIFPGVFFAVKDKTTVKNFWYYTIIVAMFNLGDFLSRLVLQFKRLHVSPRMVMIGSFARALLIIPLALCVPGTIPGVWLPYTVSLLWGLTNGYFGGLSMIYGPRTGSLTTAGQRSLAAICINVALLLGLFAGAMFALAVKEGLPKEKK
Protein: C-C motif chemokine 3 (Heparin-binding chemotaxis protein) (L2G25B) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (SIS-alpha) (Small-inducible cytokine A3) (TY-5) (P10855)
Organism: Mus musculus (Mouse)
Function: Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.
Subcellular location: Secreted.
Interaction partners:
- C-C chemokine receptor type 1
- C-C chemokine receptor type 5
- Probable C-C chemokine receptor type 3
- C-C chemokine receptor type 2
- C-C motif chemokine 4
- C-X-C chemokine receptor type 3
- C-X-C chemokine receptor type 4
- C-C chemokine receptor 1-like protein 1
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine 10
Sequence:
MKVSTTALAVLLCTMTLCNQVFSAPYGADTPTACCFSYSRKIPRQFIVDYFETSSLCSQPGVIFLTKRNRQICADSKETWVQEYITDLELNA
Protein: NAD-dependent protein deacylase SIR2rp3 (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-related protein 3) (Q584D5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:17214740}.
Interaction partners:
- NAD-dependent protein deacetylase SIR2rp1
- Cytidyltransferase-like domain-containing protein
- NAD+ synthase, putative
- ATP-NAD kinase-like protein
- Uncharacterized protein
- Nucleoside hydrolase, putative
- Inosine-adenosine-guanosine-nucleoside hydrolase
- Ribosomal RNA-processing protein 8
- SET domain-containing protein
- SET domain-containing protein
Sequence:
MRRPNGMIAILTGAGISAESGISTFRDQNGLWENHRVEDVCTPAAFLKQPTVVQRFYNERRRALLSPEVKPNASHQALARLQREYKDGQVVIITQNIDDLHERAGSRQVLHMHGELLKVRCTATGRVFESREDVIHGESKCECCGVVETLRPHIVWFNEMPLYMDVIDEVVQNAGLFVAVGTSGNVYPAAGLVMIAKAHGAETLELNLEPSGNCRDFDRSVYGPASVIVPAWADEVLHGKGPAA
Protein: Kinesin-like protein KIN-12B (Phragmoplast-associated kinesin-related protein 1-like protein) (AtPAKRP1L) (Q8L7Y8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis. Constitutes a signaling module in association with serine/threonine-protein kinase TIO that is required to support phragmoplast expansion and cell-plate growth in plant cells.
Subcellular location: Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:15258761}. Note=Localized to the midline of the nascent phragmoplast (late anaphase) and remains associated with the expanding phragmoplast ring.
Interaction partners:
- Serine/threonine-protein kinase TIO
- Kinesin-like protein KIN-10A
- Microtubule-associated protein RP/EB family member 1C
- Kinesin-like protein KIN-14E
- Microtubule-associated protein 70-4
- Kinesin-like protein KIN-14D
- AT4g37660/F19F18_150
- 65-kDa microtubule-associated protein 3
- 65-kDa microtubule-associated protein 2
- Pentatricopeptide repeat-containing protein At1g03540
Sequence:
MKHFMMPRNAILRDIGESQSPNPSLTKSKSQRKIKSSKENAPPPDLNSLIPDHRSSPAKLKSPLPPRPPSSNPLKRKLIAEATADNGVAIGVSDSGVKVIVRMKPPSKGEEEEMIVKKISNDALTINEQTFTFDSIADPESTQDEIFQLVGAPLVENCLAGFNSSVFAYGQTGSGKTYTMWGPANGLLEEHLSGDQRGLTPRVFELLFARLSEEQAKHAERQLKYQCRCSFLEIYNEQITDLLDPSLKNLMIREDVKSGVYVENLTEEYVKNLKDLSKLLVKGLANRRTGATSVNAESSRSHCVFTCVVESHCKSVADGLSSFKTSRINLVDLAGSERQKLTGAAGDRLKEAGNINRSLSQLGNLINILAEISQTGKQRHIPYRDSRLTFLLQESLGGNAKLAMVCAVSPSQSCRSETFSTLRFAQRAKAIQNKAIVNEVMQDDVNFLREVIRQLRDELQRVKDDKGNNPTNPNAAYTTSWNARRSLSLLRSFGLGHPKSLPNGDDDGDTEMEIDEEAVERLCAQMGLSPPAEDNNQEMSRVEKINSSLQTVVLKDESYNNSHLKSSEATDVNMEDACCQTENNGSETDNALTVAETMDDGSSVQPDSITNSLHSCISDTNQGNSPSKAENIPSCQDLVIEADVSAIVSVADTSNNTEQVSVNPVSPCLSVAPVSVSPVLIPPTESASPKIRNSRKSLRTTSMSTASQKDIERANQLTPEVVEPSPAMSTEVLNLYSALSTKKSEAFPVPTRQLAASLHRGMKLLDSYRQSTALRRSTFRLSYKALECKPSTVLSKADVGVQTYPQADEIAEDNSKEVLCSRCKCRAECDAQEISDTSNLQLVPIDNSEGSEKSNFQVPKAVEKVLAGSIRREMAMEEFCTKQASEISQLNRLVQQYKHERECNAIIGQTREDKIVRLESLMDGVLSKDDFLDEEFASLMHEHKLLKDMYENHPEVLQTRIELKRVQEELESFKNFYGDMGEREVLLEEIHDLKAQLQCYTDSSLTSARRRGSLLKLTYACDPNQAPQLNTIPESVDEGPEKTLEQERLRWTEAESNWISLAEELRTELDTNRLLMEKQKRELDTEKRCAEELTEAMQMAMQGHARMIEQYADLEEKHIQLLARHRRIREGIDDVKKAAARAGVKGAESRFINALAAEISALKVQREKEVRYFRDENKSLQSQLRDTAEAVQAAGELLVRFKEAEEGLTFAQKRAMDAEYEASEAYKKVDKLKRKYETEISTVNQQHNAEPQNPIESLQASCNDDAMAKYDEPSASDGDNQWREEFQPFYKKDEELSKLAEPSWFSGYDRCNI
Protein: Protein ATC1/LIC4 (AIP3 complex protein 1) (Lithium comvertas protein 4) (Q04005)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cation homeostasis and in the regulation of the cation stress signaling cascades. Also involved in bipolar budding.
Subcellular location: Cytoplasm. Nucleus. Note=The nuclear location is modulated by calcineurin.
Interaction partners:
- Periplasmic acid trehalase ATH1
Sequence:
MNTNQSNPNTDLTDDANIEHTLHRLLTQANNHFDDTVKIDGQSLDLGKDLEQVMMDNLDCTDIFDSDIASQKHLTLESLFNDEHNTDSSTLLEMQRSANDSLVGIDLDRHKKGYTGKASLDKSTNQNNVHKPDKEQKNYKIDKPTIKKKKSLLKTTNEPMLSPASLSPSSSLASSDANESHLKIESMITDITSKIDSARQDIVSATKPAKFTNEFTISQISEMKARIINTHKLLLNFNFIKEGYARSCIQLKKSMDSLKDSEIHRAHLLVENDDLKQQILELTQKLNEKSSKES
Protein: Claspin (hClaspin) (Q9HAW4)
Organism: Homo sapiens (Human)
Function: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components.
Subcellular location: Nucleus {ECO:0000269|PubMed:12766152}.
Interaction partners:
- Serine/threonine-protein kinase Chk1
- Protein timeless homolog
- TIMELESS-interacting protein
- Replication protein A 32 kDa subunit
- Replication protein A 70 kDa DNA-binding subunit
- Replication protein A 14 kDa subunit
- WD repeat and HMG-box DNA-binding protein 1
- DNA-directed primase/polymerase protein
- DNA topoisomerase 2-binding protein 1
- Cell division control protein 45 homolog
Sequence:
MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHLKTDDSTSGLTRSIFKYLES
Protein: Rab40c, member RAS oncogene family (F7F661)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
Sequence:
MAAAHPGAGLRGCAVPCGKRRAAAAAAVAAAARRLRSGGGAVGRGAAGGRMGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGSGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS
Protein: Transcriptional regulator VspR (V.cholerae 7th pandemic regulator) (VSP-1 transcription factor VspR) (Q9KVG9)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Represses the transcription of several genes encoded within the Vibrio 7th pandemic island-1 (VSP-1), including dncV, VC_0176, VC_0178 and VC_0180.
Interaction partners:
Sequence:
MRRSMKISAEMYKLLIERTLDGFSVIELRDEFIVIKDSLIDPDEAYKKVYRQILRFIKKGWLNGEGSGRQKRYFQTDTFKALHAEPKSENVDIEIVLNQDYSVLVSERNQYKGELEIVLGEIDEYQSLNIRFPELEPKLITLLDEAKERSACLLGKVNGLTNVLKVLSGQKIVHQKFKTKALLFERT
Protein: Mitochondrial intermembrane space import and assembly protein 40 homolog (AtMIA40) (Q8GYJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (Probable). Involved in the mitochondrial oxidative folding of the copper-zinc superoxide dismutase CSD1, the copper chaperone for superoxide dismutase CCS, and subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in the peroxisomal oxidative folding of the copper-zinc superoxide dismutase CSD3, and the fatty acid beta-oxidation multifunctional protein AIM1.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:20829360}. Peroxisome matrix {ECO:0000269|PubMed:20829360}.
Interaction partners:
- FAD-linked sulfhydryl oxidase ERV1
- Cytochrome c oxidase copper chaperone 1
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitochondrial import inner membrane translocase subunit TIM13
- Mitochondrial import inner membrane translocase subunit TIM8
- At5g01075
- Cytochrome c oxidase copper chaperone 2
- Transmembrane protein
- Transmembrane protein
Sequence:
MGQAQSDENSIPTTTTTNTPPPSANSPRDSEDTSSPSMDSLLAEAAAYGEDDNENESLEAKAQRALDCPCIADLRNGSCGSQFSEAFLCFLKSTAEEKGSDCVNPFVALQSCINANPDAFSKSVTGDEKETEKKEEQPPVQDHRIIPPLWAKDPPRSGNSKL
Protein: Monothiol glutaredoxin, putative (Q389T5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BolA-like protein
- BolA-like protein
- Anamorsin homolog
- Thioredoxin
- protein disulfide-isomerase
- Tryparedoxin
- Tryparedoxin
Sequence:
MLRRIFASSPAFLRCTLPNRAPDQVKPELAAAIRRIIAEDRIVIFLTGTPQEPRCGFTVKMVDMMHQLGVKYSFYNILEDDEVCEGLKIYSDWPTYPQLYIDGDLVGGYDVCKGMLLSGQLTKLLKEKDLL
Protein: RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) (Q8N7H5)
Organism: Homo sapiens (Human)
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.
Subcellular location: Nucleus {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:30367041}. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
Interaction partners:
- Parafibromin
- Transcription elongation factor SPT5
- RNA polymerase-associated protein CTR9 homolog
- RNA polymerase-associated protein RTF1 homolog
- RNA polymerase-associated protein LEO1
- Superkiller complex protein 8
- DNA-directed RNA polymerase II subunit RPB1
- FACT complex subunit SPT16
- Transcription elongation factor SPT4
- FACT complex subunit SSRP1
Sequence:
MAPTIQTQAQREDGHRPNSHRTLPERSGVVCRVKYCNSLPDIPFDPKFITYPFDQNRFVQYKATSLEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVLLDPADEKLLEEEIQAPTSSKRSQQHAKVVPWMRKTEYISTEFNRYGISNEKPEVKIGVSVKQQFTEEEIYKDRDSQITAIEKTFEDAQKSISQHYSKPRVTPVEVMPVFPDFKMWINPCAQVIFDSDPAPKDTSGAAALEMMSQAMIRGMMDEEGNQFVAYFLPVEETLKKRKRDQEEEMDYAPDDVYDYKIAREYNWNVKNKASKGYEENYFFIFREGDGVYYNELETRVRLSKRRAKAGVQSGTNALLVVKHRDMNEKELEAQEARKAQLENHEPEEEEEEEMETEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD
Protein: Probable F-box protein At3g44130 (Q9LXQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASGNLPWELEEEILCRLPLGSLVRLRSVCKHWNDFFNDKWFIKKSLGCARPQFIILPESKIYSIGTIGLDGVDPKIEVRELACQFHFEAEKWAFTAACDGLLFRDFWNQGVTIWNPWLRQVGWIEYKENRDFRFCGVGYDAGKPEKGYKIFGYFNRFYDTKLKIDHRFAIFECASQAVKFIDSPEWPMLAGRGEYVSLNGNLYWTAYNEETREHFLGSFNFSTEISMRFCLLPCAKHVSGLRDKLVLTVFKGDRFALLKQSRISKDTKVLTAQYGPKARTKKNENAEKACLKSYGSLKPDRLEKLKKSMKRY
Protein: Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) (P10938)
Organism: Bos taurus (Bovine)
Function: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine and octopamine (By similarity). Also methylates normetanephrine.
Interaction partners:
- Dopamine beta-hydroxylase
- Catechol O-methyltransferase
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- Catechol O-methyltransferase
- Tyrosine 3-monooxygenase
- Phenylalanine-4-hydroxylase
- Aromatic-L-amino-acid decarboxylase
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
Protein: Pappalysin 2 (E9PZ87)
Organism: Mus musculus (Mouse)
Interaction partners:
- Insulin-like growth factor-binding protein 5
- Stanniocalcin-2
Sequence:
MMCWKVLRISLVVLTGWALSTTNSEQGWTRKKFLAQKEHLNQVLLEGERCWLGYKVRRPRTAPQHHLFGVYPSRLENYPRSYPVGTQQQTLYAEWSQRSPERQAPSGIPRDLTENPAGARRESQQPAAPWVGDGPIGQSQLLRNDDTYLGEGGSKEALGEPAIQGSSEIAVSTIATFAYQKGPTAETQRKGQSKSRLPRQVQKRQAEDMTGDPQNTPQGFQLWPKEPLKHGDSDSPLEGTIQNGGGASLRRVETFNSQGGLPVLYFTGKRERLLLRPEVLAEIPREAFTVEAWVRPEGGQSNPAIIAGVFDNCSHTVNDKGWALGIRSGKDKGWRDARFFFSLRTDRMKKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVASSRDQFGPLNSPFMASCRSLILGGDSSEDGHYFRGYLGTLVIWSTALSQTHLQHSPLHPSAADELTTLILTATFDPLMEQWAPFRDDLYPRLEVLQDSESQPEILSPLQPPPCGQTACDNVELISQYNKHGPLRREKVIRYQVVNIYDDEGLHPIVSDHQIRRQHEALNQAFSRYNISWQLSVHRVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGFDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNVYFASSVREDLAGSATWPWDKEALSHLGGVVLNPTYYGMLGHTNIMIHEVGHVLGLYHVFKGVSERESCDDPCRETVPSMETGDLCADTAPTPKSKLCRDPEPANDTCGFTLFPGAPFNNYMSYTDDECTDNFTPNQVARMHCYLDLVYQQWSESQKPTPIPIPPMVIGQTHKSLTIHWLPPISGVVYDRAPDSMCSACTEDGTFRQYVYKASSGRVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPELHLNHMNMTVPCPAEGCSLELLFQYPVQADTLTLWVTYLSMNSSKAFFDIEILLEHKKSMHLGPLNTFCDIPLTIKLHMDEKVMGAKVYTFDERMEIDAALLTSRPNSSLCSGCKPMSYQVLREPPFSSGLPMVVTHPHRKFTDTEVIPGQMYQYQVQAEAVGELGEASPPLSHIHGGPYCGDGKVERSIGEMCDDGDLLNGDGCSRACELEEGFNCAGEPSLCYRYEGDGVCEDFEKESIITDCGLHTPEGYLDQWASQAYSYHEDKEKCPVSLVTGEPHSMICTSWHPDSSPYHSFPGWFPCVFSLKKDQDAGSEQAKDSLQKDNEIWLEVCFNRPGVAVAIYIFLASDGVTPGEHQQATVTLYLIDVSGSNHSLGTYGLSCQQNPLVINVSHHVNVYPQHTSSMLLNFSSPLVGISAVALRTSSQTSSSAPSNCIPEQNYEGKSCAQRPCGEQGRCAPLLLDHTDMVNCTSSSPGHMECAITCQRGYVLQTSSGQYLRNMQKEILLTCSSGHWDKDVICKRLDCGVPDSSLVNYANFSCLEGTDFLKQCSISCVPPAKLQGLNPWLTCLEDGLWSLPEVYCKLECEAPPVIPNANLLLPHFLEGNHDVGTICKYECKPGYYVKETSGSQGKNKFLKIQCLDDGSWEQGSCVPVVCEPPPPVFEGMYECTDGFKLDSQCVLNCNQETEGIPILCTKEGLWTQEFKLCENLQGECPPPTSELNSVEYKCGQGYGIGAVCSPSCVIPPSDPVILPENVTTDTLEHWMEPVKVQSIVCTGRRQWHPDPSLVHCIQSCEPFQADGWCDTINNRAYCNYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ
Protein: NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (Q7GHI8)
Organism: Oryza sativa (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion membrane {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003640}.
Interaction partners:
Sequence:
MDNIFFGVYNARNGYESATVLQGIRIDLAINGYESAFLSEFAPICIYLVISPLVSLIPLGVPFPFASNSSTYPEKLSAYECGFDPSGDARSRFDIRFYPVPILFIIPDLEVTFFFPWAVPPNKIDLFGSWSMMAFLLILTIGFLYEWKRGASDRE