wanglab/gogpt-training-data huggingface dataset:
Protein: Lariat debranching enzyme (EC 3.1.4.-) (O13765)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded, thereby facilitating ribonucleotide turnover.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P24309}. Cytoplasm {ECO:0000250|UniProtKB:P24309}.
Interaction partners:
- Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16
- Pre-mRNA-splicing factor cwf19
- Pre-mRNA-splicing factor 18
- UPF0768 protein C1952.04c
Sequence:
MSYFARLKPPPAFLKMRVGVQGCCHGILDNLYILAEKRKVDLLIIGGDFQALRNVSDYHGISMPPKFKRLGDFFNYYNGRNKAPILTIFVGGNHEASNYLDELPYGGWVAPNIYYMGRSSVINVGGLRIAGISGIYSAMDYKKGRYEGLPYNYKMLKSIYHTREFDVLSLKSLQKPIDIFLSHDWPRGIEQHGDVAKLLRHKPFFRNEVERNDLGSPALEELLVELKPRYWMAAHLHTKFTAVVHHNSQEDDGKLSCSSKDVTSSGFSMKGLNEPSQERLPVEKEQNDKSDEEGSNNEQEEKQDKKQSTNRDLCRKESCKKEPSLSSSDQVTKFLALDKCLPRRSYFEVVEIEPVEIPDSGAPYMQYDSEWLSVLRAMHPFQSHTIEQDPPLPSLEVVKTLKRKEEIWVDENLVKKDKLGIPRNFCQTAPPHSRDITENMQPSSYINPQTVAFEILIGLKERTVDSPPPVKNPNEIVL
Protein: Leucine aminopeptidase A1, chloroplastic (LapA1) (EC 3.4.11.1) (DR57) (Leucyl aminopeptidase 1) (LAP 1) (Proline aminopeptidase 1) (EC 3.4.11.5) (Prolyl aminopeptidase 1) (Q10712)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Presumably involved in the processing and regular turnover of intracellular proteins.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:17896114}.
Interaction partners:
- Peptidase M1 alanyl aminopeptidase C-terminal domain-containing protein
- Glutathione hydrolase
- Glutathione hydrolase
- glutathione-specific gamma-glutamylcyclotransferase
- glutathione-specific gamma-glutamylcyclotransferase
- Glutathione synthetase, chloroplastic
- Leucine aminopeptidase
- glutathione-specific gamma-glutamylcyclotransferase
- Cytosol aminopeptidase domain-containing protein
- Glutamate--cysteine ligase, chloroplastic
Sequence:
MATLRVSSLFASSSSSLHSNPSVFTKYQSSPKWAFSFPVTPLCSKRSKRIVHCIAGDTLGLTRPNESDAPKISIGAKDTAVVQWQGDLLAIGATENDMARDENSKFKNPLLQQLDSELNGLLSAASSEEDFSGKSGQSVNLRFPGGRITLVGLGSSASSPTSYHSLGQAAAAAAKSSQARNIAVALASTDGLSAESKINSASAIATGVVLGSFEDNRFRSESKKSTLESLDILGLGTGPEIERKIKYAEHVCAGVILGRELVNAPANIVTPAVLAEEAKKIASTYSDVISVNILDAEQCKELKMGAYLAVAAAATENPPYFIHLCFKTPTKERKTKLALVGKGLTFDSGGYNLKVGAGSRIELMKNDMGGAAAVLGAAKALGEIRPSRVEVHFIVAACENMISAEGMRPGDIVTASNGKTIEVNNTDAEGRLTLADALIYACNQGVEKIIDLATLTGAIMVALGPSVAGAFTPNDDLAREVVEAAEASGEKLWRMPMEESYWESMKSGVADMINTGPGNGGAITGALFLKQFVDEKVQWLHLDVAGPVWSDEKKNATGYGVSTLVEWVLRN
Protein: Dorsal interacting protein 4 (GEO03784p1) (GM08377p) (Lesswright, isoform A) (Lesswright, isoform B) (Lesswright, isoform C) (Lesswright, isoform D) (RE25737p) (Ubiquitin-conjugating enzyme 9) (Q7KNM2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ubiquitin-related modifier
- Ran GTPase-activating protein
- SUMO-activating enzyme subunit
- Suppressor of variegation 2-10, isoform I
- Activator of SUMO 1
- LD23870p
- BTB/POZ domain-containing protein Tiwaz
- Protein roadkill
- TAR DNA-binding protein 43
- L-serine deaminase
Sequence:
MSGIAITRLGEERKAWRKDHPFGFVARPAKNPDGTLNLMIWECAIPGKKSTPWEGGLYKLRMIFKDDYPTSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAITIKQILLGIQDLLNEPNIKDPAQAEAYTIYCQNRLEYEKRVRAQARAMAATE
Protein: Small ribosomal subunit protein uS12m (Ribosomal protein S12, mitochondrial) (P28520)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Protein S12 is involved in the translation initiation step.
Subcellular location: Mitochondrion.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Os01g0220300 protein
- Small ribosomal subunit protein uS2c
- Small ribosomal subunit protein bS16c
- Large ribosomal subunit protein bL27c
- Small ribosomal subunit protein eS19
- Os10g0411700 protein
- Os07g0658200 protein
- Small ribosomal subunit protein uS9c
- Os02g0102400 protein
Sequence:
MPTKNQLIRHGREEKQRTDRTRASDQCPQKQGVCLRVSTRTPKKPNSALRKIAKVRLSNRHDIFAHIPGEGHNSQEHSIVLVRGGRVKDSPGVKSHRIRGVKDLLGIPDRRKGRSKYGAERPKSK
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit (EC 3.1.3.16) (Calcineurin subunit A) (Q7YSW8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalytic subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals.
Interaction partners:
- Calcineurin subunit B type 1
- Calcineurin subunit B type 2
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- FK506-binding protein 1
- Suppressor of Mek1
- Modulatory calcineurin-interacting protein
- Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco8
Sequence:
MSTNNNKAPTSQSSDKSATTESKLNDNENTETETKTDENNEEKPKMTLKPPQPKIENKVSTIDRVVPSVKYPKSLPLPHDVLFNEDKTINLPKLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSPEIREHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDATGFPSVITLFSAPNYLDAYNNKGAVLRYENNVMNIRQFTCSPHPYWLPNFMDVFTWSMPFVSEKVAEMLLVLLNLCNDEEAEKNENAQTVKDTSEEEKRRQMLRAKVKSVSKMMRMFSLLRQERETIMMIKSFSPSRKIPQGLLTEGKDALKKALGDFAQARKMDLINEKRPPILDRVNSRGELLRMNSRGELFRINSKGDLFRSNSYADLKPPQGPQETIKITECHEQNITTNNINPNSITTNENNSNEQLQQQQQQQQQQQPPTTTSTTTQTEVAK
Protein: Transmembrane protein (Q382U1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIHATGDFCIGALFVGLWLAASVLPFSRVGAMLEDRDHPFAAPLHMMKAILLVVLGAWAICYALIGELGLLFPANVWRFTPEFCFYALGRHTLRQVAILLYCIIISTPGAVLSSKGRRRCETRECDGADIELDELHSGREAVVPILNCIHGAVEMGRSAGSDSFREPHISFNGSRSHLPSRTNRDDNSRLHSAAAPAEWNNTHTYSPCENGVGPGYLHEGGVVMPSDIHIQLKPSLSVSDTDSFMDGPFSSSSVHFRDSGANPASQFPRGSRVNMNSSSFPPSRVHNNEECGIRFGAASVREAESYTVPLNQQTLVSVHISGGASSATRKPPNSFKRKLCFVRNWLTGGPLPTFGTDDEVTRATDKCGPLVHRWKRLVLWDAVLKLRLVLLMWIITFTLVVYLAVAASFEDVQACHEPISETAICWVNRSATPAQRLHPPRSFTTIFLFSDVILLLVWMICGVRCLQNIGNITAKQKFRRAYLMGASLIMLSITYSCFSIFDPLRYNGIVTVVLLIFRNVCDLLLILLLVVQVENSSGPKPSWLIWLRGTVVYGK
Protein: Zinc finger protein CONSTANS-LIKE 5 (Q9FHH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- B-box zinc finger protein 32
- ASI1-immunoprecipitated protein 1
- MADS-box protein SOC1
Sequence:
MGFGLESIKSISGGWGAAARSCDACKSVTAAVFCRVDSAFLCIACDTRIHSFTRHERVWVCEVCEQAPAAVTCKADAAALCVSCDADIHSANPLASRHERVPVETFFDSAETAVAKISASSTFGILGSSTTVDLTAVPVMADDLGLCPWLLPNDFNEPAKIEIGTENMKGSSDFMFSDFDRLIDFEFPNSFNHHQNNAGGDSLVPVQTKTEPLPLTNNDHCFDIDFCRSKLSAFTYPSQSVSHSVSTSSIEYGVVPDGNTNNSVNRSTITSSTTGGDHQASSMDREARVLRYREKRKNRKFEKTIRYASRKAYAESRPRIKGRFAKRTETENDDIFLSHVYASAAHAQYGVVPTF
Protein: Pre-mRNA-splicing factor prp5 (Complexed with cdc5 protein 1) (Pre-mRNA-processing protein 5) (O13615)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for both cell cycle progression at G2/M and pre-mRNA splicing. Interacts genetically with the PRP4 kinase.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing factor cwf4
- U2 snRNP component prp10
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-splicing factor syf2
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cwf5
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor cwf3
Sequence:
MTEAKNISDDTDVLSLTTNSLRTSKTLFGAEFGSVTSFDDTVAQNLKRTYKEHLEYGSVLGGTVGKRKNRHYEEDTIGSNALTVRADSENPSSQVITKFSDPNKKIAGQVSMQSLEKIKGVPEAAHRIAGESQASLVKRTLAEQIRPEWHAPWTLMRVISGHLGWVRCVDVEPGNQWFCTGAGDRTIKIWDLASGVLKLTLTGHIATVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYALKLHPTLDVLVTAGRDAVARVWDMRTRQNVHVLSGHKSTVASLAVQEFDPQVVTGSMDSTIRLWDLAAGKTLTTLTHHKKTVRALSLHPDEFTFASGSSDNIKHWKFPEGAFMGNFEGHNAIVNTLSINSDNVMFSGADNGSMCFWDWKSGHKYQELQSVVQPGSLDSEAGIFASSFDKTGLRLITCEADKSVKIYKQVDNATPETHPNLPWTPSNLRRRY
Protein: Metalloprotease YcaL (EC 3.4.-.-) (P43674)
Organism: Escherichia coli (strain K12)
Function: Involved in the degradation of the LPS-assembly protein LptD. Degrades LptD that have engaged the Bam complex but are stalled at an early step in the outer membrane protein assembly process.
Subcellular location: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Beta-barrel assembly-enhancing protease
Sequence:
MKNTKLLLAIATSAALLTGCQNTHGIDTNMAISSGLNAYKAATLSDADAKAIANQGCAEMDSGNQVASKSSKYGKRLAKIAKALGNNINGTPVNYKVYMTSDVNAWAMANGCVRVYSGLMDMMNDNEIEGVLGHELGHVALGHSLAEMKASYAIVAARDAISATSGVASQLSRSQLGDIAEGAINAKYSRDKESEADDFSFDLLKKRGISTQGLVGSFETLASLDGGRTQSMFDSHPPSTERAQHIRDRIASGK
Protein: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (A0A0G2K542)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSQMVFNLSKAMSQDGASQFQEVILQELELSVKKELEKILTTATSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLLPIAKDVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIEEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNPKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
Protein: Serine/threonine-protein kinase BSK (EC 2.7.11.1) (Brassinosteroid-signaling kinase) (Q9LFD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193, ECO:0000256|RuleBase:RU369005}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193, ECO:0000256|RuleBase:RU369005}.
Interaction partners:
- Putative acyl-activating enzyme 19
Sequence:
MGCICFKSWRRSSSSPSITSTVIDDLENVREYDADDDGGHYPLIFREFSLEQLRIATDGFSAGNIVSEHNDSVPNIVYKGKLGDGRRIAVKRFQRLSWPDPFEFINEAQAVGRLRSEHMANLIGCCCDDNERLLVAEYMPNGTLAKHLFHWEKRPMKWEMRLKVALHTARALEYCNDKGIDLYHDLNPYRIMFDKTGIPKLSCFGLMKNSHEGKIYSTNLAFAPPEYLRLGTVIAESVTFSFGTLLLDLMSGRHIPPNHALDLFRGKNYLVLMDSALDGQFSDEDRTELIHVASRCFKTEPEERPSIKFLKATLSRLQKRAKLCPINVKRPMSPPSKNLPEKTKPATESLKLTPFGDACSRADLSSIHELLEKLGYEEDNGVGNEFSFQMWTGEMQENMDYKKHGDAAFLAKDFDTAIEFYTEFMTGAPTVSPTVLARRCLCYLMTEMFSEALSDAMQAQVASPEWPIPLYLQAACLFKLEMEAEAKEALRHGSALEAY
Protein: VPS10 domain-containing receptor SorCS1 (hSorCS) (Q8WY21)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Sortilin
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 35
Sequence:
MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAERGEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGNAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI
Protein: Alpha-L RNA-binding motif/Ribosomal protein S4 family protein (At5g15750) (Ribosomal protein-like) (Q683D4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Protein NUCLEOLAR COMPLEX ASSOCIATED 4
- U3 small nucleolar RNA-associated protein 18 homolog
- Probable U3 small nucleolar RNA-associated protein 11
- AT1G07840 protein
- At3g57000
- Nucleolar protein
- Protein TORMOZ EMBRYO DEFECTIVE
- Uncharacterized protein At3g06530
- Ribosomal RNA-processing 7 protein
- KRR1 small subunit processome component
Sequence:
MRKLKYHEKKLIKKVNFLEWKREGNHRENEITYRYHMGSRDDYKKYSGLCRMVQKLTNIMKQMDPADPFRIQMTDMLLEKLYNMGVIPTRKSLTLTERLSVSSFCRRRLSTVLVHLKFAEHHKEAVTYIEQGHVRVGPETITDPAFLVTRNMEDFITWVDSSKIKRKVLEYNDTLDDYDMLA
Protein: Tachykinin-related peptide 3 (TKRP-3) (P86565)
Organism: Banasa dimiata (Banasa stink bug) (Pentatoma dimiata)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
GPSSGFFGMR
Protein: Superoxide-generating NADPH oxidase heavy chain subunit C (EC 1.-.-.-) (NADPH oxidase C) (Superoxide-generating NADPH oxidase flavocytochrome C) (Q54F44)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Critical component of the membrane-bound oxidase that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- NADPH oxidase activator
Sequence:
MEKQKNISIKKFANPLSFPHEFRTNLHKSTFLDASLLELPNISVDKTKNENNFSITDKILMESLKENEFKIREFIKNQESGNRVLMIDKNSLKELFNINDNQALDLIFNQYVQSTRPNLIRKSSNSSLNIDLKKEIKKKTKKSRKSFSRNSKLNNNDSKIDDKNDNYIDKINDINNFNSDIEEIFKKKKEIENTLKIPIGGNSFPIPVEFNNNNNNNNNNNNNNNNNYNNNIDNNNNNNNNNNNNNINNCNNNNINNDNNNNNNNDNDNNNINTVDNHDDDIINNSNNFNKNEYPSSNISPISPKSSISSFPTNLNNSINNTGSMVSDSLSSCRNSISSSSIDSSVASIPITIQSIDFEDKNIKSDQFKIISKSNIENTIETNPIPPFNQTNNQCEVQLQSHSLPTILKQPHIYKSKSFSSSINSNSKIKKIKKSRSFEIESKINLFDVINHIYLNLSKVGSEEQKITSVFKLYDIYDKGFISRDDLKEVLNYRTKQNGLKFQDFTMESLIDHIFQQFDKNMDGYIDFEEFKSELTINNENKVKEKEENTNYNFKEENIGIYTEKESFHSLKRYLKIEGSKLFFISLFFIINSILVITSFLNVHANNKRAIELFGPGVYITRIAAQLIEFNAAIILMTMCKQLFTMIRNTKFKFLFPVDKYMTFHKLIGYTLIIASFLHTIGWIVGMAVATGKPDNIFYDCLAPHFKFRPTVWEMIFNSLPGVTGFIMISFLIIMAILSLKIIRKSNFELFYYSHHLFIGFYVLLILHGTMGWIRPPTFWKWFIVPGFFYTVDRSFRLFKRTHRVEVLDYCLKNERVINLTFSKPPSFDYKPGQYLLINVPHISKLQWHPFTMTSSPLEDKIYVHIRVTGNWTKKLFRWLSIKKQLQQQQQLYNNIKQQNVLPDGSNFIINNNNNIDQIDLEIGLKPFRINIDGPFGSSSQYALKQKQVILVGAGIGVSPMASLLKDISLKKQRLQLLNQGDQIALEQSKNEITTKFGLGNLEKVHFFWLNRDQHSFQWFEDLLIDISTNGNSNLPKISINTFNTRVFPKNDVRVFMLWNGLDKLFKAQGLDPTTNLPFKTHWGRPNWDTIFQYYSKKYSGESISVFCCGPSQLSKELYEKCRYYTCLKTGGTKFYFHKENF
Protein: E3 ubiquitin-protein ligase RDUF1 (EC 2.3.2.27) (RING and DUF1117 domain-containing protein 1) (AtRDUF1) (RING-type E3 ubiquitin transferase RDUF1) (Q9SNB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid-dependent drought stress responses. Involved in the positive regulation of responses to salt and osmotic stresses during seed germination and early seedling development. Possesses E3 ubiquitin ligase activity in vitro.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23951086}. Nucleus {ECO:0000269|PubMed:23951086}.
Interaction partners:
- Elongation factor G, putative
- Chaperone DnaJ-domain superfamily protein
- Aspartic proteinase Asp1
- Eukaryotic aspartyl protease family protein
- Aspartic proteinase Asp1
- At3g50050
- Eukaryotic aspartyl protease family protein
- Eukaryotic aspartyl protease family protein
- Eukaryotic aspartyl protease family protein
- DUF724 domain-containing protein 2
Sequence:
MMPNSRSATITPTTESTTTTTTTTTTLTTSYWCYSCTRFISVWEDQDANAGVLCPYCNGGFIEEIEDSSNSTVAAIPASTPEVRSVEETHRSIIRRRRSNRRTSFNPVIVLHGGGGGGAGERVENEEGDGATRERRAYEFYYDDGSGSGLRPLPDSVSEILMGSGFERLLEQLSQIEASGNGIGRSGNPPASKSAIESLPRVEISDCHTKAEANCAVCTEVFEAGIEGREMPCKHIFHGDCIVPWLSIRNSCPVCRFELPSDPIQRSNEEEHAVGMTIWRLPGGGFAVGRFNAGVREGERILPVVLTEMDGGGLGSNEGPRRISWVRAHETPEMSRNGGRSGNGGRLRRAVRGMVSFMRRVRPSRGSSNSNVIDLDSDGETRVMNRSTSLIRRFF
Protein: Uncharacterized protein (Q55GT3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MESGPVVIDVSRFLADPTSAEALEDCKKLVKTLQETSCLVIKHPKVNEEDNSRFLDMMEKYYEQPTEELMKDVHPEWSYQLGATPEFTEEPRDHSEVITKLLPQYAAHAPKGADPKWRFFWRIGDRPEDTKFPELNCAPVIPKAFPEWQNVMDSWGSLMLSSIETVSEMIATGYNLPKDSITNLMKNGPHLLAPTGSDLKRFGNLDQIFAGFHYDFNLLTIHGKSRYPGLYIWLRDGTRVPVKVPNGCLLLQAGKQLEWITGGDILAGFHEVVVTEDTLKVMEKSKDEGKSLWRISSTLFGHVASDKNLTLLEPFNNPQNLEKYPNILAGKQSEAELEMIKLSKK
Protein: Uncharacterized oxidoreductase C26H5.09c (EC 1.-.-.-) (O13991)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Probable gluconokinase
- Probable glucose-6-phosphate 1-dehydrogenase C7.13c
- Vitamin B6 transporter bsu1
Sequence:
MAPIKTAVLGTGMSAFIFHYPFLKALPNHFEVYAAWERRATSTESKARAAFPNVKVYTKLDELLADSNIELVVISLPPNVHYEVVSQALNAGKHVLCEKPFTPTYGEAKELFDLAKSKNLMLTVYQNRRFDGDFLTAKECIENGRLGEVVQFESHIDRFRLFRKGNWKDVPNPGCGLVYDLGSHLIDQAITLFGTPHSVTAKLESQRQIPPLEVEDCFRIVLHYLPQEGRLPLDVIVCSSSISCGLDMRYIIKGTRGSFLKFGIDPQESQLNEGMSPMDPGYGVDSSHHYATLWTLPPDIDVRHPPKPTKSTLMTIAGDYRRFYLEVHEALVTKTFETSVKPHQVLLVEKIIEAAYKSSQSSTSIPLSE
Protein: 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) (Q13442)
Organism: Homo sapiens (Human)
Function: Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.
Interaction partners:
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
Sequence:
MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK
Protein: CCT domain-containing protein (A0A178U8Q1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00357}.
Interaction partners:
Sequence:
MCGHVSTSITSGDNCPCFLYSDDIVAPPQLLDHHHHQFPPPPLALLMMSQNSLYAAEAVSGFGYFDSGMNGGGGSSSCDSPSSMGSGGESLVMQRSVSSHNGFSGNYTAAHDFVNDDDGPVRRALSAGDLPRSSRRESSTVWSESNAIIEGMSKAYKYSPEEKKEKIEKYRSKRNLRNFNKRIKYECRKTLADSRPRIRGRFARNDEISQQEQVDVMEAVVGDVDTWASFLDSFSANHFLN
Protein: Clusterin-associated protein 1 homolog (Q6I6D4)
Organism: Caenorhabditis elegans
Function: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:15713455}. Cell projection, cilium {ECO:0000269|PubMed:15713455}. Cell projection, dendrite {ECO:0000269|PubMed:15713455}.
Interaction partners:
- Intraflagellar transport protein che-13
- TRAF3-interacting protein 1
- Intraflagellar transport protein 56 homolog
- Tetratricopeptide repeat protein 30 homolog
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein osm-1
- CHE-2 protein
- Intraflagellar transport protein 81 homolog
Sequence:
MSYRELRNLCEMTRSLRYPRLMSIENFRTPNFQLVAELLEWIVKKFEPESNLDAHEVQTEADRVAFIKNAVLLMLQNSRIKMNPKKLYQADGHAVQELLPAMKILYQAKAEDPNTDNSPKWTQVKNKLSSKMQEVRITRQLSSQLPETGALLSELLSRQEFISQQHERAASRAVPLAEAEKVLQATVQNIAQETEQLSNKLNNVASDEAELDEKIERKKREYEQLQKRFAKLQSFRPQYMDEYERFEERLKKLYEVYVLNFRNLSYLRKVHDDLARSERQRQEELEKAMRMAVEKMRLEQEKKDAIGLHDDDGSDAPLVDRRQSVRKVYGNMMGGDASDDDEDDEDDEDDEIIRMDDNVAQHHKRELHRQEEDEERSEADYMVGITTAHVADDAKSDLSSGDDF
Protein: ADP-ribosylation factor like GTPase 13B (M0RDU9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Intraflagellar transport 88
- Pericentrin
- Centrosomal protein of 164 kDa
- Meckelin
- Kinesin-like protein
- Centrosomal protein 290
- Intraflagellar transport protein 81 homolog
- Protein fantom
Sequence:
MFNLMANCCNLFKRWREPVRKVTLVMVGLDNAGKTATAKGIQGEHPEDVAPTVGFSKIDLRQGKFEVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDEDRMEETKETMSEVLRHPRISGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAVLGYGKKIDKSIKKGLYWLLHIIAKDFDALSERIQKDTTEQRALEEQEKCERAERVRKLREEREQEQTELDGTSGLAEMDSGPVLTNPFQPIAAVIIENEKKQEKEKKKKTAEKDSDVGHPEHKGEQEGAESQNEAGGCLRNPHRDVVNSYKEALSQQLDNEDELDQRVSEPGDNSKKKTKKLRMKRSHRVEPVNTDESAPKSPTPPPPPPPVGWGTPKVTRLPKLEPLGETRHNDFYGKPLPPLAVRQRPNGDAQDMIS
Protein: Nexilin F-actin binding protein (H7BXY5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIETDDY
Protein: ABC transporter, periplasmic substrate-binding protein (Q7DA51)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
Sequence:
MRQGCSRRGFLQVAEAAAATGLFAGCSSPKPPPGTPGGAAVTITHLFGQTVIKEPPKRVVSAGYTEQDDLLAVDVVPIAVTDWFGDQPFAVWPWAAPKLGGARPAVLNLDNGIQIDRIAALKPDLIVAINAGVDADTYQQLSAIAPTVAQSGGDAFFEPWKDQARSIGQAVFAADRMRSLIEAVDQKFAAVAQRHPRWRGKKALLLQGRLWQGNVVATLAGWRTDFLNDMGLVIADSIKPFAVDQRGVIPRDHIKAVLDAADVLIWMTESPEDEKALLADPEIAASQATAQRRHIFTSKEQAGAIAFSSVLSYPVVAEQLPPQISQILGA
Protein: Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (Q63046)
Organism: Rattus norvegicus (Rat)
Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Core-binding factor subunit beta
- Forkhead box P3
- RUNX1 partner transcriptional co-repressor 1
- Transcription factor PU.1
- CCAAT/enhancer-binding protein alpha
- Histone deacetylase 1
- Endothelial transcription factor GATA-2
- TAL bHLH transcription factor 1, erythroid differentiation factor
- GATA-binding protein 3.
- Protein C-ets-1
Sequence:
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSTSRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGTSAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY