wanglab/gogpt-training-data huggingface dataset:
Protein: G2/mitotic-specific cyclin-A1 (P34638)
Organism: Caenorhabditis elegans
Function: Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 4 homolog
- Cell division control protein
- CDT1 Geminin-binding domain-containing protein
- Serine/threonine-protein kinase plk-1
- DNA replication licensing factor mcm-6
- Cyclin-dependent kinases regulatory subunit
- Cullin-1
- DNA replication licensing factor mcm-5
Sequence:
MRSALSLKPSNGNAAKSQAVNNKNVIKNAPLGGKLTRQIGTSNLLQQALPSKKIDESPIIKIDAKDSFKVFEDQEPEKENSSENVDATEKDSNVIPAEDNNMIHELERKMEEKSRAEKLKFKFMQTRDNSDITSRFSEPPSEFSVLCDDDDCDKVSVASSTFTTSVRATFSSFHFDENQRKKEFGKEEAVKKIQKKAAKEARDDSMFSSEEFFPDIIKYMLHRQTKNRASHECFDIQSQVNEEMRTILIDWFSDVVKEYNFQKETFHLAVSLVDRALSMFNIDKMRFQLVGTTSMMIAVKYEEIFPPEIEDFALITDNTYRVPDILLMERFLLGKFDFVVAMPTSSWFGTCFAKRMNFTKKMRNTVHYLLELSLIDVHFLRYRPSDIAAAACCFANLQADVESWPQKMVDDTGISTEDFVDVLRDLHRMYLNASTADFKSIFYNYSETAQMEVALLPAPTDKLRSMFPSIFVTAPKSSNDSSSPQ
Protein: Exocyst complex component 3-like protein (Protein Jiangli) (Q86VI1)
Organism: Homo sapiens (Human)
Function: As part of the exocyst, may play a role in regulated exocytosis of insulin granules.
Subcellular location: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Colocalizes with insulin granules. {ECO:0000250}.
Interaction partners:
- Exocyst complex component 2
- Exocyst complex component 4
- Exocyst complex component 1
- Exocyst complex component 5
- Exocyst complex component 8
- Exocyst complex component 7
- Exocyst complex component 6
- Exocyst complex component 6B
- Exocyst complex component 1-like
- Exocyst complex component 3-like protein 2
Sequence:
MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRSREVQRTCSLESRLKSVMQSYLEGVQTGVWQLAQAIEVVQGTREALSQARGLLQGMSQALQTLEPLRERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFLEAYVSLRELEQLREDTWAPLGGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPALLVAAVRVAEVETGRTTPLGQVPRDWRQRCLRALQEGLEQAHFGSPLLPAPGALPGWLEALRVALPVELATAEALVAPCCPPQYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADAFALLHWALHVYLGQEMMGSLELGPEADVSQLEPLLTLENIEQLEATFVANIQASVSQWLQNALDGEVAEWGREHGPNTDPSGSYYSPMPAIVLQILEENIRVASLVSESLQQRVHGMALSELGTFLRSFSDALIRFSRDHFRGKSMAPHYVPYLLAALNHKSALSSSVSVLQLDGAPSGALAPVEAALDELQRRIYRLVLEALQAELQPLFADLPSRQWLSSPELLQSVCERTGRFCRDFWRVRNPTVQLLLAEAERAVVLQYLSALMQGRLVCRGADERTQAAERLRHDAAQLQQLFLSLGLEENAHCAPVLLALRELLNLRDPALLGLEVAGLRQQFPDVSEDHVSALLGLRGDLSREQHLAALSSLQAALPPSPRASRRVLFSLVPAPALAPASCLPSGSCARALLLAE
Protein: Putative steryl acetyl hydrolase mug81 (EC 3.1.1.-) (Meiotically up-regulated gene 180 protein) (Q9HDV1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the deacetylation of acetylated sterols (By similarity). Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MISLSLLYRILTLPIILVGTTILYFTIGTNFPHDELRHNLLSTLFCSSMLHLSKGLTVKDVRIFFHDSIGSTLLKNRKKLNSENELPNYGEKFTHKYDNQDMPDSVWLAKVNGMTKSDPIILHLHGGMMALPYDKVILVGLSNLYKLFSTTMNRPPSILLVDYSLVSQGYTYPKQVRECLNVYQVLISKGFRNITVLGESAGGTLILSFLYQISELSKLNKVVWPKGVALISPWLDLTNAKKIGSYRANDGLDVICYETLNRFGKAYVNNEESLFTSSVVNINMNCDISIWSKIPPIQDGKVLVLFGENEVFRDEILSWTSKIGLLKAYPNRVLMDKQGIHIGLFLEESPSIGPGMTNLDIWKKKFSVNSLYTFLRETFEE
Protein: Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2) (Q5T2D2)
Organism: Homo sapiens (Human)
Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Trem-like transcript 1 protein
- Triggering receptor expressed on myeloid cells 2
- CD276 antigen
- Triggering receptor expressed on myeloid cells 1
- TYRO protein tyrosine kinase-binding protein
Sequence:
MAPAFLLLLLLWPQGCVSGPSADSVYTKVRLLEGETLSVQCSYKGYKNRVEGKVWCKIRKKKCEPGFARVWVKGPRYLLQDDAQAKVVNITMVALKLQDSGRYWCMRNTSGILYPLMGFQLDVSPAPQTERNIPFTHLDNILKSGTVTTGQAPTSGPDAPFTTGVMVFTPGLITLPRLLASTRPASKTGYSFTATSTTSQGPRRTMGSQTVTASPSNARDSSAGPESISTKSGDLSTRSPTTGLCLTSRSLLNRLPSMPSIRHQDVYSTVLGVVLTLLVLMLIMVYGFWKKRHMASYSMCSDPSTRDPPGRPEPYVEVYLI
Protein: Probable WRKY transcription factor 32 (WRKY DNA-binding protein 32) (P59583)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SI37}.
Interaction partners:
Sequence:
MEEDTGIDEAKTYTVEKSEKVEPEKDGLSQFRDEEKSLGADMEDLHDETVRETLGKDQVQGVRENSSVEPNVEDVLEVNETDSVKETVVSAIVPVDEVEENRQVETSPSLAASSDSLTVTPCLSLDPATASTAQDLPLVSVPTKQEQRSDSPVVNRLSVTPVPRTPARDGYNWRKYGQKQVKSPKGSRSYYRCTYTECCAKKIECSNDSGNVVEIVNKGLHTHEPPRKTSFSPREIRVTTAIRPVSEDDTVVEELSIVPSGSDPSASTKEYICESQTLVDRKRHCENEAVEEPEPKRRLKKDNSQSSDSVSKPGKKNKFVVHAAGDVGICGDGYRWRKYGQKMVKGNPHPRNYYRCTSAGCPVRKHIETAVENTKAVIITYKGVHNHDMPVPKKRHGPPSSMLVAAAAPTSMRTRTDDQVNIPTSSQCSVGRESEKQSKEALDVGGEKVMESARTLLSIGFEIKQC
Protein: Ethanolamine kinase 2 (EKI 2) (EC 2.7.1.82) (Ethanolamine kinase-like protein) (A7MCT6)
Organism: Mus musculus (Mouse)
Function: Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity.
Interaction partners:
- Ethanolamine-phosphate cytidylyltransferase
- Ethanolamine-phosphate phospho-lyase
- Glycerophosphocholine phosphodiesterase GPCPD1
- Ethanolaminephosphotransferase 1
- Choline/ethanolaminephosphotransferase 1
- Regulatory-associated protein of mTOR
Sequence:
MAVPPSAPVPCSPFYLRRQEPCPQCSWSMEEKAVASAGCWEPPGPPRAAVPCFSVTVEQDDILPGALRLIRELRPHWKPEQVRTKRFKDGITNKLLACYVEEDMRDCVLVRVYGERTELLVDRENEVRNFQLLRAHGCAPKLYCTFQNGLCYEYVQGVALGPEHIREPQLFRLIALEMAKIHTIHANGSLPKPTLWHKMHRYFTLVKDEISPSLSADVPKVEVLEQELAWLKEHLSQLDSPVVFCHNDLLCKNIIYDSDKGRVCFIDYEYAGYNYQAFDIGNHFNEFAGVNVVDYSRYPARETQVQWLRYYLEAQKGTAASPREVERLYAQVNKFALASHFFWALWALIQNQYSTISFDFLRYAVIRFNQYFKVKPQVSALEMPK
Protein: Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) (P06401)
Organism: Homo sapiens (Human)
Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
Subcellular location: Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; SUBCELLULAR LOCATION: [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion outer membrane {ECO:0000269|PubMed:23518922}.
Interaction partners:
- Nuclear receptor coactivator 1
- Nuclear receptor corepressor 1
- Nuclear receptor corepressor 2
- Heat shock protein HSP 90-alpha
- Nuclear receptor coactivator 3
- Receptor tyrosine-protein kinase erbB-2
- Heat shock protein HSP 90-beta
- Peptidyl-prolyl cis-trans isomerase FKBP4
- Peptidyl-prolyl cis-trans isomerase FKBP5
- Estrogen receptor
Sequence:
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Protein: Rac-like GTP-binding protein ARAC8 isoform X2 (Small GTPase) (Q0PZE6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- Protein LOL2-like
- Protein LOL2-like
- Kinesin-like calmodulin-binding protein
- Kinesin-like calmodulin-binding protein
- Protein TIME FOR COFFEE-like
- Guanine nucleotide exchange factor SPIKE 1-like
- Guanine nucleotide exchange factor SPIKE 1-like
- Actin
- Actin
- Actin
Sequence:
MASSASRFIKCVTVGDGAVGKTCMLICYTSNKFPTDYIPTVFDNFSANVVVEGTTVNLGLWDTAGQEDYNRLRPLSYRGADVFVLAFSLVSRASYENILKKWIPELQHYAPGVPVVLVGTKLDLREDKHYLADHPGLLPVSTAQGEELCKQIGAAYYIECSSKTQQNVKAVFDAAIKVVIKPPQKQKEKKKKPSRGCLINVFCGRNFVPAK
Protein: Lin-9 DREAM MuvB core complex component (H0Y322)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPFRNSKRSRLFSDEDDRQINTRSPKRNQRVAMVPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRTGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPIIDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD
Protein: Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (E9Q5C9)
Organism: Mus musculus (Mouse)
Function: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (By similarity). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q14978}. Cytoplasm {ECO:0000250|UniProtKB:Q14978}. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. {ECO:0000250|UniProtKB:Q14978}.
Interaction partners:
- Nucleolar protein 56
- rRNA 2'-O-methyltransferase fibrillarin
- Nucleolar protein 58
- H/ACA ribonucleoprotein complex subunit DKC1
- Ribosomal L1 domain-containing protein 1
- RNA 2'-O-methyltransferase FBLL1
- H/ACA ribonucleoprotein complex subunit 1
- H/ACA ribonucleoprotein complex subunit 2
- DNA-directed RNA polymerase I subunit RPA1
- Coilin
Sequence:
MADTGLRRVVPSDLYPLVLRFLRDSQLSEVASKFAKATGATQQDANASSLLDIYSFWLNRSTKAPKVKLQSNGPVTKKAKKETSSSDSSEDSSEDEDKKAQGLPTQKAAAQVKRASVPQHAGKAAAKASESSSSEESSEEEEEDKKKKPVQQKAAKPQAKAVRPPAKKAESSESDSDSDSDSSSEEETPQTQKPKAAVAAKAQTKAEAKPGTPAKAQPKVANGKAAASSSSSSSSDDSEEEKKAAAPPKKTVPKKQVVAKAPVKVAAAPTQKSSSSEDSSSEEEEGQRQPMKKKAGPYSSVPPPSVPLPKKSPGTQAPKKAAAQTQPADSSDDSSDDSDSSSEEEKKPPAKTVVSKTPAKAAPVKKKAESSSDSSDSDSSEDEAPAKPVSTTKSPKPAVTPKPSAAKAVTTPKQPAGSNQKPQSRKADSSSSEEESSSSEEEEASKKSATTPKAKVTAKAAPAKQAPQAAGDSSSDSDSSSSEEEEKTPKPPAKKKAAGGAVSTPAPGKKAEAKSSSSSSSSSSEDSSEEEKKKKPKATTPKIQASKANGTPASLNGKAAKESEEEEEEEETEEKKKAAGTKPGSGKKRKQNETADEATTPQAKKVKLETPNTFPKRKKGERRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSVKFDSE
Protein: Serine/threonine-protein phosphatase 5 (EC 3.1.3.16) (Q84XU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Isoform 2 dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms, and enhances phytochrome-mediated photoresponses, probably by enhancing their stability and their binding affinity for light signal transducers such as NDPK2. Can use para-nitrophenylphosphate (pNPP) as substrate.
Subcellular location: [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus, nucleoplasm. Nucleus speckle. Note=Cytoplasmic in darkness, but translocated to the nucleus upon illumination, when associated with phytochromes into speckles.
Interaction partners:
- Co-chaperone protein p23-2
- Probable protein phosphatase 2C 9
- Probable esterase KAI2
- Co-chaperone protein p23-1
- Ubiquitin-like superfamily protein
- Phytochrome A
- Proton pump-interactor 2
Sequence:
METKNENSDVSRAEEFKSQANEAFKGHKYSSAIDLYTKAIELNSNNAVYWANRAFAHTKLEEYGSAIQDASKAIEVDSRYSKGYYRRGAAYLAMGKFKDALKDFQQVKRLSPNDPDATRKLKECEKAVMKLKFEEAISVPVSERRSVAESIDFHTIGNKPRSSSMPTKTALAAVVAAVMVVAVRGFATTEILMVLVSVVLGTFWWGSFSGKVEPQYSGARIEGEEVTLDFVKTMMEDFKNQKTLHKRYAYQIVLQTRQILLALPSLVDISVPHGKHITVCGDVHGQFYDLLNIFELNGLPSEENPYLFNGDFVDRGSFSVEIILTLFAFKCMCPSSIYLARGNHESKSMNKIYGFEGEVRSKLSEKFVDLFAEVFCYLPLAHVINGKVFVVHGGLFSVDGVKLSDIRAIDRFCEPPEEGLMCELLWSDPQPLPGRGPSKRGVGLSFGGDVTKRFLQDNNLDLLVRSHEVKDEGYEVEHDGKLITVFSAPNYCDQMGNKGAFIRFEAPDMKPNIVTFSAVPHPDVKPMAYANNFLRMFN
Protein: Exodeoxyribonuclease 10 (EC 3.1.11.-) (Exodeoxyribonuclease X) (Exo X) (Exonuclease X) (P0AEK0)
Organism: Escherichia coli (strain K12)
Function: Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.
Interaction partners:
- Uncharacterized protein YobB
- Single-stranded-DNA-specific exonuclease RecJ
- Exodeoxyribonuclease I
- DNA mismatch repair protein MutH
- DNA helicase II
- Flap endonuclease Xni
- DNA mismatch repair protein MutL
- DNA polymerase III subunit theta
- Exodeoxyribonuclease 7 large subunit
- Ribonuclease T
Sequence:
MLRIIDTETCGLQGGIVEIASVDVIDGKIVNPMSHLVRPDRPISPQAMAIHRITEAMVADKPWIEDVIPHYYGSEWYVAHNASFDRRVLPEMPGEWICTMKLARRLWPGIKYSNMALYKTRKLNVQTPPGLHHHRALYDCYITAALLIDIMNTSGWTAEQMADITGRPSLMTTFTFGKYRGKAVSDVAERDPGYLRWLFNNLDSMSPELRLTLKHYLENT
Protein: Chromobox protein homolog 6 (Q9DBY5)
Organism: Mus musculus (Mouse)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:16537902}. Chromosome {ECO:0000269|PubMed:16537902}. Note=Localizes to the inactivated X chromosome in females. {ECO:0000269|PubMed:16537902}.
Interaction partners:
- Chromobox protein homolog 8
- E3 ubiquitin-protein ligase RING1
- Polyhomeotic-like protein 3
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 2
- Polycomb complex protein BMI-1
- E3 SUMO-protein ligase CBX4
- Polycomb group RING finger protein 1
- Chromobox protein homolog 2
- Polycomb group RING finger protein 6
Sequence:
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGPGGGSTAQGTGALARPKVPSRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLAPSTAGKADVASSGPGLLLATPAAAPFDAHSSSSSGCPSPTLQSSDPDDAPPKLLPETLSRSVPNWRESEVLDLSIPPEAAATGQRVPPDVTGAADQALHTALEPTGAGSSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCSPEDFEKVAAGVAGATGGGGGTGPSK
Protein: 40S ribosomal protein S12 (Q38AC1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 40S ribosomal protein S8
- 40S ribosomal protein S15, putative
- 40S ribosomal protein S14
- Ribosomal protein S19, putative
- 40S ribosomal protein S16, putative
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S4
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S33, putative
Sequence:
MADENQVEKQVEPTPVVEVIDVEPDTLQDAIRIVIRKALEVNGLVRGLSEVARALDRRTAHMCILATDCDDEEYKKLIKALALQASIDIIEVDSREELAEWAGLQRRKQDETVKTFKCSCVAIRDFGERTKALDMLLNKLSH
Protein: REX4 homolog, 3'-5' exonuclease (A0A0C4DG22)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSKKKPKIIQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGLTRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKP
Protein: Envelope phospholipase OPG057 (EC 3.1.1.-) (EC 3.1.4.4) (37 kDa protein) (Envelope phospholipase F13) (Palmitoylated EV membrane protein) (p37K) (P04021)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell. Produces the wrapped form of virus that is required for cell-to-cell spread. Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities.
Subcellular location: Virion membrane {ECO:0000269|PubMed:12706074}; Lipid-anchor {ECO:0000269|PubMed:12706074}. Host Golgi apparatus, host trans-Golgi network {ECO:0000269|PubMed:27466413, ECO:0000269|PubMed:29540596}. Host endoplasmic reticulum membrane {ECO:0000269|PubMed:12706074}; Lipid-anchor {ECO:0000269|PubMed:12706074}; Cytoplasmic side {ECO:0000269|PubMed:12706074}. Note=Component of the inner side of the enveloped virion (EV) membrane. F13 is associated post-translationally with membranes.
Interaction partners:
Sequence:
MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTTRGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGCFWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFNSAKNSWLNLCSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLKSAKTSIDIEHLAIVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQNDLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFERDWVSSHSKSLKI
Protein: Solute carrier family 25, member 27 (A0A8I5ZVX7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MILEGFVGLSECFGGFPPLRLFSISLATFPLDLTKTRLQMQGEAALAKLGDGAMESAPYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGEYLVLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRMEDTLLHRDCDLQGATLYPSLETGVLSDSSFYLRAICLVQSHETNH
Protein: Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) (P0CC10)
Organism: Rattus norvegicus (Rat)
Function: Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner.
Subcellular location: Membrane {ECO:0000269|PubMed:19252495}; Single-pass membrane protein {ECO:0000269|PubMed:19252495}. Presynaptic cell membrane {ECO:0000269|PubMed:19252495}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase F
- Receptor-type tyrosine-protein phosphatase S
- Netrin-G1
- Interleukin-1 receptor accessory protein-like 1
- Adhesion G protein-coupled receptor L1
- Disks large homolog 4
- Adhesion G protein-coupled receptor L3
- Neurexin-2
- Adhesion G protein-coupled receptor L2
Sequence:
MAQAHIQGSPCPLLPPGRMSWPQGALLLLWLFSPPLRAGGGGVAVTSAAGGGSPPATSCPAACSCSNQASRVICTRRELAEVPASIPVNTRYLNLQENSIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGPGGGGPGGGGGAGGAGGYTYFTTVTVETLETQPGEEAQQPRGTEKEPPGPTTDGAWGGGRPDAAAPASASTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVAGGAGVGGDSHLALPALERDHLNHHHYVAAAFKAHYGGNPGGGCGAKGPGLNSIHEPLLFKSGSKENVQETQI
Protein: Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) (Q569C4)
Organism: Rattus norvegicus (Rat)
Function: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q969S8}. Nucleus {ECO:0000250|UniProtKB:Q969S8}. Note=Excluded from nucleoli. {ECO:0000250|UniProtKB:Q969S8}.
Interaction partners:
- Histone deacetylase 11
- Nuclear receptor corepressor 2
- NAD-dependent protein deacetylase sirtuin-1
- Core histone macro-H2A
- Histone H2A
- Histone H2A.Z
- Core histone macro-H2A.1
- Histone H2B
- Histone H2A type 2-A
- Histone H2B
Sequence:
MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCQCLSVCEASEEELGLVHSPEYIALVQKTQTLDKEELHTLSKQYDAVYFHPDTFHCARLAAGAALRLVDAVLTGAVHNGVALVRPPGHHSQRAAANGFCVFNNVAIAARHAKQKYGLQRILIVDWDVHHGQGIQYIFEDDPSVLYFSWHRYEHGNFWPFLPESDADTVGRGRGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAVLECPGVYPECSDSPDPSLDKPPTNSTCTVAEDSLSPCLDRPCHRPTPPICIAVALAVSGAALDLPPGVLHQEGSALREETEAWARLHKSQFQDDDLAALGKSLCLLDGILDGQIRSAIATTTALATAATLGVLIQRCVAHRGQRRILWLSIRGKEADIWSMFHFSTPLPQTTGGFLSFILGLVLPLAYGFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVGGRILALVEEESILQLARTLAQVLHGETPPSLGPFSMASPEEIQALMFLKAQLEPRWKLLQVAAPPP
Protein: Peptide chain release factor PrfB3, chloroplastic (AtPrfB3) (F4J264)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the light- and stress-dependent regulation of stability of 3' processed petB transcripts, thus regulating cytochrome b6 accumulation, a rate-limiting step in photosynthetic electron transport. May be recruited to specifically protect petB transcripts against 3'-5' exonucleolytic attack by masking the 3' ends. Does not function as release factor.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:21771930}. Plastid, chloroplast {ECO:0000269|PubMed:30962391}.
Interaction partners:
- At5g64156
- AT3g13440/MRP15_7
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL31c
- Pentatricopeptide repeat-containing protein At5g42310, chloroplastic
- 1-
- Large ribosomal subunit protein uL24c
- Deoxyhypusine hydroxylase
- Large ribosomal subunit protein bL27c
Sequence:
MAAKIIGGCCSWRRFYRKRTSSRFLIFSVRASSSMDDMDTVYKQLGLFSLKKKIKDVVLKAEMFAPDALELEEEQWIKQEETMRYFDLWDDPAKSDEILLKLADRAKAVDSLKDLKYKAEEAKLIIQLGEMDAIDYSLFEQAYDSSLDVSRSLHHYEMSKLLRDQYDAEGACMIIKSGSPGAKSQIWTEQVVSMYIKWAERLGQNARVAEKCSLLSNKSGVSSATIEFEFEFAYGYLLGERGVHRLIISSTSNEECSATVDIIPLFLRASPDFEVKEGDLIVSYPAKEDHKIAENMVCIHHIPSGVTLQSSGERNRFANRIKALNRLKAKLLVIAKEQKVSDVNKIDSKNILEPREETRSYVSKGHKMVVDRKTGLEILDLKSVLDGNIGPLLGAHISMRRSIDAI