wanglab/gogpt-training-data huggingface dataset:
Protein: Malectin domain-containing protein (Q9VIG0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Inactive rhomboid protein 1
- Transmembrane protein 258
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Sequence:
MQQGELRRKKTTTIADMCNVACKTGIFRNYLRASGQRTWMSVLLVLVLMGTFTAAEPLKVIYAVNAGGDEHTDLNGVQYDADPLKGVGIASDYGKHLLMIGRVQEHDEVLYRTERYHTTTFGYDLPSDGDGDYALIMKFCEVYFDAPQKKVFDVLLNRKHTVVRQLDIYNEVGRGSAHDEIVYFKINNGRLNYEGEVSDVRNGRLRLDFIKGALDNPKINAFALLKGDISQVPRMHGTEATERIKPEGKLNAEQKKAQQVERVVRNQRDDIDEDDEDLDDEEFEEELSEQNVDKLGSDQPSLQSDTKRSYSGPRQPNPYSMDDSSILLPVFIAIGAFIPLLFCLCKL
Protein: Cyclic di-GMP binding protein BcsE (Cellulose biosynthesis protein BcsE) (P37657)
Organism: Escherichia coli (strain K12)
Function: Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP), the ability to bind c-di-GMP is important for its function.
Interaction partners:
- Cellulose biosynthesis protein BcsF
- Cellulose biosynthesis protein BcsG
- Protein YhjR
- Cellulose synthase catalytic subunit
- Cyclic di-GMP-binding protein
- Endoglucanase
- Probable diguanylate cyclase DgcC
Sequence:
MRDIVDPVFSIGISSLWDELRHMPAGGVWWFNVDRHEDAISLANQTIASQAETAHVAVISMDSDPAKIFQLDDSQGPEKIKLFSMLNHEKGLYYLTRDLQCSIDPHNYLFILVCANNAWQNIPAERLRSWLDKMNKWSRLNHCSLLVINPGNNNDKQFSLLLEEYRSLFGLASLRFQGDQHLLDIAFWCNEKGVSARQQLSVQQQNGIWTLVQSEEAEIQPRSDEKRILSNVAVLEGAPPLSEHWQLFNNNEVLFNEARTAQAATVVFSLQQNAQIEPLARSIHTLRRQRGSAMKILVRENTASLRATDERLLLACGANMVIPWNAPLSRCLTMIESVQGQKFSRYVPEDITTLLSMTQPLKLRGFQKWDVFCNAVNNMMNNPLLPAHGKGVLVALRPVPGIRVEQALTLCRPNRTGDIMTIGGNRLVLFLSFCRINDLDTALNHIFPLPTGDIFSNRMVWFEDDQISAELVQMRLLAPEQWGMPLPLTQSSKPVINAEHDGRHWRRIPEPMRLLDDAVERSS
Protein: Probable capsular polysaccharide biosynthesis protein YwqC (P96715)
Organism: Bacillus subtilis (strain 168)
Function: Required for YwqD kinase activity. May bring YwqD and its substrates into contact. Probably involved in the regulation of capsular polysaccharide biosynthesis.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tyrosine-protein kinase YwqD
- Putative tyrosine-protein kinase YveL
- Tyrosine-protein phosphatase YwqE
- UDP-glucose 6-dehydrogenase YwqF
- Uncharacterized protein YveK
- Serine/threonine-protein kinase YabT
Sequence:
MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIYENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQELNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKAEVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLGTVSTIANEQKTAKTLQGFQSEKTGSGHFGA
Protein: Sperm associated antigen 9 (H0YBS5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSI
Protein: ATPase phospholipid transporting 11B (putative) (A0A0C4DG94)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKVCLHMFEYCSW
Protein: Cyclin-I (Q14094)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:28860486}.
Interaction partners:
- Cyclin-dependent kinase 5
Sequence:
MKFPGPLENQRLSFLLEKAITREAQMWKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVYRPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q9NGX8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MNWAIYLLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPEVLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPTAEQGINIIATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQQQLQPYQGRNPCQERNLAPLTMRTPPVLVERSKKHSFQTQPQENSLSCLEHDVCVEELIASHQHQQQKNTIVSTGGNGNSCLGQGFPKQQNTDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKSNLVTALRRPNNLDLSPRLDKPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHINGTTNNNSIQSHGSELQTLTRPASKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFREVFSGRGSSERLRDPSERVKTPGDVPPSVRKARASKTLSLYDDRMMDSSLLNIL
Protein: Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (G3MU81)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MQCSPDPEDLLIVPTHDIPSYDESLDPFGPEGHLSLDIDCFSKFMSRSDNRIMSKPIIVRGIPWRILAICRNQQGSRHSMNSRVNRSNFNFGFFLQCNNDELLQKRGMWRCYGTAVLEVLNADGPSIQKKIHHSFHNTEVDWGFSNYDQYDTLCNPKDGYVVNDTIKLRCRFTADVPTGANYMWDSKRHTGCIGLRNQGATCYMNSILQSFYFTTGFRRAVYNMDVGTEPNESNIVLAMQRVFYELQMASEAVETNSLTRAFGWDKLDAFNQHDVQEFCRVLLDNLETKMKGTSEEKSIPNLFRGNMKSYIKCLDVDYESSRTESFYDVQLNVLGMDSLERAFEAYTTSEILDDENKYDAGDHGLQRAEKGVKFVELPPILHVQLMRFQYCGVEQKINERFSFPEKMNLASCCELGPMLTEEDCVYSLHAVLVHSGEFHGGHYVTYINVNLHESAVDPTSSAKWCKFDDDVVSRTTTDDAIVSNFGGEKTMNSSAYMLVYVRDNAIDQFLAPIPDSQIPQSVSRTFEMERLHRNREKKKLEEEQLCMGIVLVTPDIVASNHSFDLVDQSIVHDSIPHETVWKHMFTAELYQFVHDRLFEKSAMQKIDMFDSDDEARQARRDNLRRIKSKKFNFRLWRMTDSYSLERTTQKLTSRLRPSEFIDCKTDTRLDTLLSQDFETIYVEFSNNIERPLCEYDTARDLLFFVKYYDTMTDKFTIIGHTMFDCHKRFNLYRSMLCEMIGLPADTELKYYMEHAASYLELVDLTQNYSIGRLVEEQDGGILVVEKVETSTSTQNAKQKMNELFLDVEVEFVQSFYNKKPEEEPFEQFVKRICLDDKLFTVAEEIGARLNVDPKKVLIWTRVSGSRFEPFFDDYMLNTCKGLMTRPVHDPRAYKRYRVQYAIMPFDIDEISKHRIQTKLFWQLPNGHVEELTLFPLKEGTVIDIINEAKRYYPFVEGGSGKFRLLQIGAPPLSNQRVYQIYGENTLISDLDQRTMYKLALHCRLEEVPIDELDMSPGEFLCPVVHFDREPTKLFGLSFVIKIRNNELMTEVRDRLRRKLNDVSDADFAKYKFALLSRDKLCRTIEFNNGEKVNLADMANQTTGVPQVYIGLDHKSPIQHSSEAAIRILN
Protein: Signal recognition particle protein (EC 3.6.5.4) (Fifty-four homolog) (O07347)
Organism: Thermus aquaticus
Function: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00306}. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00306}.
Interaction partners:
Sequence:
MFQQLSARLQEAIGRLRGRGRITEEDLKATLREIRRALMDADVNLEVARDFVERVREEALGKQVLESLTPAEVILATVYEALKEALGGEARLPVLKDRNLWFLVGLQGSGKTTTAAKLALYYKGKGRRPLLVAADTQRPAAREQLRLLGEKVGVPVLEVMDGESPESIRRRVEEKARLEARDLILVDTAGRLQIDEPLMGELARLKEVLGPDEVLLVLDAMTGQEALSVARAFDEKVGVTGLVLTKLDGDARGGAALSARHVTGKPIYFAGVSEKPEGLEPFYPERLAGRILGMGDVASLAEKVRAAGLEAEAPKSAKELSLEDFLKQMQNLKRLGPFSEILGLLPGVPQGLKVDEKAIKRLEAIVLSMTPEERKDPRILNGSRRKRIAKGSGTSVQEVNRFIKAFEEMKALMKSLEKKKGRGLMGMFRR
Protein: Frizzled-2 (Fz-2) (mFz2) (Frizzled-10) (Fz-10) (mFz10) (Q9JIP6)
Organism: Mus musculus (Mouse)
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Protein Wnt-5a
- Protein Wnt-3a
- Protein Wnt-7a
- Proto-oncogene Wnt-1
- Protein Wnt-11
- Protein Wnt-7b
- Protein Wnt-2
- Tyrosine-protein kinase RYK
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-4
Sequence:
MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
Protein: Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) (Q6P2K6)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions (By similarity). {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase 4 regulatory subunit 3B
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Protein phosphatase 3 catalytic subunit alpha
- CREB-regulated transcription coactivator 2
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta
Sequence:
MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPTLSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQNDDDILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSKDDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAFLALCALRFKRKIIGLKDEFYNRYIMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNHRYRRDARTLEDEEEMWFNTDEDDMEDGEAVVSPSDKTKNDDDIMDPISKFMERKKLKESEEKEVLLKTNLSGRQSPSFKLSLSSGTKTNLTSQSSATSLPGSPGSPGSPGSPGSPGSVPKSTSQTAAITTKGGLVGLVDYPDDDEDDDEDEDKEDTLPVSKKAKFES
Protein: Universal stress protein E (P0AAC0)
Organism: Escherichia coli (strain K12)
Function: Required for resistance to DNA-damaging agents.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Universal stress protein F
- Universal stress protein UP12
- Universal stress protein A
- Fumarate and nitrate reduction regulatory protein
- Universal stress protein D
- Universal stress protein C
- Methylated-DNA--protein-cysteine methyltransferase
- Universal stress protein B
- Uncharacterized protein YnaJ
- UPF0208 membrane protein YfbV
Sequence:
MAMYQNMLVVIDPNQDDQPALRRAVYLHQRIGGKIKAFLPIYDFSYEMTTLLSPDERTAMRQGVISQRTAWIHEQAKYYLNAGVPIEIKVVWHNRPFEAIIQEVISGGHDLVLKMAHQHDRLEAVIFTPTDWHLLRKCPSPVWMVKDQPWPEGGKALVAVNLASEEPYHNALNEKLVKETIELAEQVNHTEVHLVGAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGINENMTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGISAAFLGNTAEQVIDHLRCDLLVIKPDQYQTPVELDDEEDD
Protein: Ribonuclease P protein subunit p25-like protein (RNase P protein subunit-like p25) (Rpp25-like protein) (Q8N5L8)
Organism: Homo sapiens (Human)
Function: May be a component of ribonuclease P or MRP.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ribonuclease P protein subunit p30
- Ribonuclease P protein subunit p20
- Ribonuclease P protein subunit p29
- Ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p38
- Ribonuclease P protein subunit p40
- Ribonucleases P/MRP protein subunit POP1
- Ribonuclease P protein subunit p21
- Ribonuclease P protein subunit p25
- Ribonuclease P protein subunit p14
Sequence:
MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRDGSKIRNLLGLALGRLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPASPDTGLDPLTVRRHVPAVWVLLSRDPLDPNECGYQPPGAPPGLGSMPSSSCGPRSRRRARDTRS
Protein: Carboxylesterase 1E (EC 3.1.1.1) (Carboxyesterase ES-3) (ES-HTEL) (Egasyn) (Liver carboxylesterase 3) (pI 5.5 esterase) (Q63108)
Organism: Rattus norvegicus (Rat)
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters.
Subcellular location: Endoplasmic reticulum lumen. Microsome membrane {ECO:0000269|PubMed:7945287}.
Interaction partners:
Sequence:
MCLYALILVFLAAFTAGGHPSSLPVVDTLQGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQIVNDLLTNWEENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPLAEKIAVVSGCKSTTSASMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPFVPTVLDGVVLPKMPEEILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDDPDRNKDQLLELIGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVVGDHGDEIYSVFGAPILRGGTSKEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKEGYLQIGATTQQAQKLKEKEVAFWSELLAMKPLHAGHTEL
Protein: Nestin (P21263)
Organism: Rattus norvegicus (Rat)
Function: Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Interaction partners:
- Neuronal migration protein doublecortin
- RNA binding protein fox-1 homolog 3
- Tubulin beta-3 chain
- Fibroblast growth factor 2
- Prominin 1
- Paired box protein Pax-6
- Oligodendrocyte transcription factor 2
- Cyclin-dependent kinase 5
- Synemin
- Homeobox protein NANOG
Sequence:
MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVVRPSKEGNLESWTAFKEESQHPLGFPGAEDQMLERLVEKEDQSFPRSPEEEDQEACRPLQKENQEPLGYEEAEGQILERLIEKESQESLRSPEEEDQEAGRSLQKGNQEPLGYEEAEGQILERLIEKESQESLRSAEEEDQEACRSLQKENQEPLGYEEAEDQILERLIEKESQESLRSPEEEDQEAGRSLQKENQEPLGYEEAEDQMLERLIEKESQESLKSPEENQRIGKPLERENQKSLRYLEENQETFVPLESRNQRPLRSLEVEEEEQRIVKPLEKVSQDSLGSLAEENVQPLRYLEEDNCINKSLLEDKTHKSLGSLEDRNGDSIIIPQESETQVSLRPPEEEDQRIVNHLEKESQEFSRSSEEEERVMERSLEGENHESLSSVEKEDQMVESQLEKESQDSGKSLEDESQETFGPLEKENAESLRSLAGQDQEEQKLEQETQQTLRAVGNEQMAVSPPEKVDPELPKPLGNDQEIARSLGKENQESLVSLKEKGIETVKSLETEIIEPLETAEEDLERRKSIDTQEPLWSTEVARETVEPPEDEPPGSLGSVDENRETLTSLEKESQELSSLGKWNVETRVEDSQQCLQVEEGLQEEQHQESLREVKQELPSSGNQQRWEDVVEGKAVGQEAPLATTGVGTEDKAELHLRGQGGEEEAAAEGELLQDIVGEAWSLGSSEPKEQRVPAEALDNLEGGALEVPVAQSMPEVTERDEDRAQAGEQDSIEVTLGLEAARTGLELEQEVVGLEDPRHFAREEAIPPSLGEESVKAKIAQGLEGPGKEPKEAGALDSGILELPKTSSEALECQGHEESESMEGWEEEEASLETSDHEGSDAPQPRPPETEEDEGAQAALTAPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGSEALERVENEPEFGLGEIPEGLQDWEEGREESEADDLGETLPDSTPLGLYLRSPASPKWDLAGEQRLSPQGDAGKEDWGPAVPAAQGLSGPPEEEEEQGHGSDLSSEEFEDLGTEASLLPGVPKEVADHVGQVPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEGAESGAQWWGSGASGGGCKVQDIAQRGDPVQESVGVSGLWDDGLRGAAANVPALEMVSQDSAEPSGSEESESASLEGEEGQVTDHLDAPQEVTSMVPGVGDAFDIGGQSPNLDSEQVNGKMENGLEQAEGQVVLDGDEDQELLLQGQEVGALKVPLVASPVHLGPSQPLKFTLSGVDGDSWSSGED
Protein: Four and a half LIM domains 1 (Q5JXH9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHE
Protein: Microtubule-associated protein (A0A0B4KI45)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU000686}.
Interaction partners:
Sequence:
MADVLEKSSLLDAVPPLGDPHPPLPHQQLQQEAAAAAAANAAPPAPPQQQQPPPHQLQQQQPQQQQLQQKPANARANQDQKEGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSSKPDKSGTSRPPSATPSNKSAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKGGEKKIVTTKLQWNAKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKSPLPSMTASGADENLNQQS
Protein: Dihydrofolate reductase (EC 1.5.1.3) (P9WNX1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Interaction partners:
- Thymidylate synthase ThyA
- Flavin-dependent thymidylate synthase
- Dihydrofolate synthase/folylpolyglutamate synthase
- Winged helix-turn-helix domain-containing protein
- Methionyl-tRNA formyltransferase
- Methionine synthase
- Phosphoribosylglycinamide formyltransferase
- Aminomethyltransferase
- Bifunctional purine biosynthesis protein PurH
- Serine hydroxymethyltransferase 2
Sequence:
MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
Protein: Aquaporin gamma-TIP (B1NHU1)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPISRIAVGSPAEAGQADALKAALAEFISVLIFVFAGEGSGMAFNKLTDDGSSTPAGLVAAALAHALALFVAVSIGANISGGHVNPAVTFGAFVGGHITLVRSILYWIAQLLGSVVACFLLKFSTGGMTTSAFSLSSGVGAWNAVVFEIVMTFGLVYTVYATAVDPKKGNIGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWDNHWVYWLGPFIGSAIAAIVYEVFFIAPSTYEEVPSADF
Protein: Glutathione S-transferase (EC 2.5.1.18) (E7EWW9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNGMLGSLVAQLSFAGFPSIQLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
Protein: Claudin-2 (SP82) (P57739)
Organism: Homo sapiens (Human)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:20460438}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tight junction protein 1
- Occludin
- Claudin-12
- Tight junction protein ZO-3
- Tight junction protein 2
- Claudin-1
- Claudin-7
- Claudin-11
- Claudin-5
- Claudin-3
Sequence:
MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV
Protein: Atypical chemokine receptor 3 (A0A140T9K6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLI
Protein: Glycolipid transfer protein (GLTP) (Q9NZD2)
Organism: Homo sapiens (Human)
Function: Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17980653}.
Interaction partners:
- Pleckstrin homology domain-containing family A member 3
- Ceramide-1-phosphate transfer protein
Sequence:
MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
Protein: Death domain-containing protein (IKB-1) (G5EFS1)
Organism: Caenorhabditis elegans
Interaction partners:
- Pelle-like serine/threonine-protein kinase pik-1
- TNF Receptor Associated Factor
- TIR domain-containing protein
- Amyloid-beta-like protein
Sequence:
MSKADENDANLTENGVHKSRSDSEINSHTSSIHKSSSQHRRLFIDDISTIEASAGDRVWATCSGAGDATELITIHFLGDQFEESAIDVVRKHSLVMFTVPSLKVDSELEVELRFSTSNDNVTTISFKYLPRKIQRSHTQEISLFDNLLEFATNGDTISLLQPFVAQISKQDIEGNTVFHVAAKNGQSFSLKLLLSVIPPDIKNEVINVQNTHGLTALHVAIRTGDPDAVHYLMNHGAKIDISDNHGSTALHYLGDAYNESIFKEILEPSRGQRFDVNQLNSEGFAPIHVAVRRLKLSLIEMLIEAGALIDFLDTEKKRNALMHAIEMNDFETIQLLVERGSGTNIEDESGETALSLAVKNVNYPVIGLLLDNGADPNRQNSKGICLADSEDSVIQNIINGDRPELPKKEAFGVPNDLAISRSPLFGRSHPDQAPGEESGRHRVVKRSREEILNDAQTLLAETDSMAPRVSRISTSESEDEQQPGPSTSSGTRRRRSEWDRNPKLSDSVCNLDYLTRIRVAKIFDDQCKWQRLAQQLNCDHMVELISICSSGDDSSPTMILLDQFEQLEDSSISRLRDAMNQMAEDDAVKLIDSRYVY