Protein: Mediator of RNA polymerase II transcription subunit 13-like (Thyroid hormone receptor-associated protein complex 240 kDa component-like protein) (A2VCZ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 14
- Cyclin C
- Cyclin-dependent kinase 19
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
Sequence:
MSSCFVPNGASLEDCHSNLFCLADLTGIKWKCFVWQGPTSSPILFPVTEEDPILCSFSRCLKADVLSVWRRHQTPGRRELWIFWWGDDPNFAELVHHDLSCNEDGSWESGLTYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFVHGDSNVCTSVEINQHQPVYLLSEEHLTLAQQSSSSVQVILSPYGLSGTLTGQSFKLSDPPTQKLIEEWKQFYPIGPNTKEVTDDKMDDLDWEDDSLAAVEVVVAGVRMVYPASLVLVAQSDIPLVATVSSSSSSGSYAGAPHNQLVHGDTGISSVTLTPPTSPEEAQAVSQPAQKWVKLSAMSGVFSVDSSSHHGGKIPRRLASQMVERVWQECNINRAQNKRKFSTMSNGVCEEETDKASVWDFVESSQRSQCSCSRLKNQKQRACSTPGHPPSAGQPPQPSTKHKMAEKLEKGDKQQKRPLTPFHHRSSLCEEQPSLEQGESVHRLCLQGHEDSRYPSLHHADVTSSKTPMLHSSADEMAGSPQPPPLSPHPCERMEEPADGMKSSSSPLHQHFYPPSSEPCLEPQKPPDESTLDPLPLPCPPPYPETLEATIYVGSAINPNEDTTHNPWKYFRVPGGRNSDFHTPHLPVVAHFEDGNRTGGQDGIVSITEMMSSSKRPLKVSEELVKMYEHKKNQYLSSAVCDEDPEQESDPYAFEEGDEEFNFSDKDKKSGPEREAGKKAKREDGSSSSDDAQGSGGSKPLPTTSLIHETDLVVSINDLDNLFNSDEDDLTQPGSRRAAGGAEEKFGGKEPKPAAPDPLPCCADLHQMFPTPPSLDQGYSPINMGNTESAAGLSLLDGAMSGNFKMEVEEGFCSPKPSEIKDFSYVFKPESCQALIGCSLYAPLKTLPSQCLLPVKLPEECVYRPSWTVGKLGMLQPMAAMTFLNKDSNIPSVGSVVEQEQSCTPQTHNTFMSNSAPPSNSGAGILPSPATPRISAPTPRTPRTPRTPRGPASVQGSLKYENSDLNSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNITGADVGIYISDPNMDSQYSSMDPCSCGFSAVMNRRYGNGAGLFLEDELDIMGRGSDAAREIEKHFEAVRAASLKRGTVLEEQVPDDLMLLLQDLCTNPFSPIIRPDLLGTVIKSPIRLEERDYYSDCYMALEHGRQFMDNMSGGKVDETLVKSSSLHHWAKRNAFDMSMLFSQDVLRMLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTLLVGYEYDYVVLSPFALPYWEKLLLDPYSSQRDVGYMVVCPDNEALLNGAKTFFRDLTAVYESCRLGQHRPIAKSHADGIVTVSDAGSKALTDQTLIDWLPKTINSSSSSEALNKLKLYAHVCRHDLASCLASQSLDGSLLTQRNPASSSQTSSSSSPVTTAQNVTPTTNSNSNTNTNTTPTSTSTSSSSSSCPQGVGNMPSSKPNTIPPFGAQGLQSSQQSGGQSAGTLGDATSATSQPQVPSEPAESTMEREKVGVPTDGDSHAVTYPPAIVIYIVNPFSYEENCQGSSSSVWTIALLRCYLEMLQLLPPHIRNAVYVQIIPSQYLLQPVWSEERHIYAQHLKSLAFSVYTQCRRRLPTSTNVKTLTGFGPGLAIDTALQSKERPQCLHLYAPPFVLAPVKDKQTELGETFGEAAQKYNVLFVAYCLSHDQRWLLASCTDQYGELLETCVISIDVPNRARRKKGSARRQGLQKLWEWCLDLVQMTSLPWRIVIGRLGRIGHGELRDWSILLSRRNLQSLGRRLKEMCRMCGISAADSPSILSTCLVAMEPQASFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAGLQAFSDVTDGMGGMDGILDLFAENDLVDPDLINIIPNSPTTSPVHSPGSHYHHGGDGSKGQGTDRMESHDESPNILQQPMALGYFVSTAKAGPLPDWFWSSCPQAKNQCPLFLKASLHLNVSSVQSDELLHSKHSHPLDSSHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQMYNFIMNML