wanglab/gogpt-training-data huggingface dataset:
Protein: Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (rVDAC1) (Q9Z2L0)
Organism: Rattus norvegicus (Rat)
Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane (By similarity). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (By similarity). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (By similarity). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). May mediate ATP export from cells (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796, ECO:0000269|PubMed:17178908}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21796}. Cell membrane {ECO:0000250|UniProtKB:P21796}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21796}. Membrane raft {ECO:0000250|UniProtKB:P21796}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21796}. Note=Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites. {ECO:0000269|PubMed:17178908}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC3
- Non-selective voltage-gated ion channel VDAC2
- ADP/ATP translocase 1
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Creatine kinase S-type
- Creatine kinase U-type, mitochondrial
- Stress-70 protein, mitochondrial
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Translocator protein
- ADP/ATP translocase 2
Sequence:
MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVNGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDVDFDIAGPSIRGALVLGYEGWLAGYQMNFETSKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQVDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
Protein: MutS protein homolog 4 (P40965)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
Interaction partners:
- DNA mismatch repair protein MLH3
- MutS protein homolog 5
- DNA mismatch repair protein MLH1
- DNA mismatch repair protein MLH2
- DNA mismatch repair protein PMS1
- ATP-dependent DNA helicase MER3
- Meiosis-specific protein SPO11
- Crossover junction endonuclease MUS81
- Sporulation-specific protein 22
- Meiotic recombination protein REC8
Sequence:
MSESNLSSFISTNYFNLRSAANSSNSISKPSTKKSIRNQKSPTNISSWALKKKTLQIAETTWENNEKDSTHSHYLMTGSMASRTATSLSRYSTNASLLGPSIDCVLCCIYEVPRDISTRIGLCIINCNTGQMYLSDFMDSQIYIRVVHKLQIYQPTEILIPSSSLAPTVSKLATMIKFNVAETVKIEEGSRKCFNSQDGLAAITKYLMDDTKKDLKIEEIIDKTFALCAASAAISYMEEIISKSSRNLNAFRKLRIQFEGTENTMLIDSKTVRGLELVENKLDKNGISLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKANDDLLQKLRLEMKSLPDLDKLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALNDQLIQSRLISETKKIFNNDAIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNGLLDVSRQIYKEVKEEFFREVEDLTAKNKINLDHNYDSARGFYLRIKRQEFTDDVATLPDVFISRTIKKNYIECTTLNIIKKNARLKEVMEEILLLSEETVDELLDKIATHISELFMIAEAVAILDLVCSFTYNLKENNYTIPIFTNNLLIRDSRHPLLEKVLKNFVPNTISSTKHSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSFPVFKRLHARVCNDSMELTSSNFGFEMKEMAYFLDDINTETLLILDELGRGSSIADGFCVSLAVTEHLLRTEATVFLSTHFQDIPKIMSKKPAVSHLHMDAVLLNDNSVKMNYQLTQKSVAIENSGIRVVKKIFNPDIIAEAYNIHSLLKIAKARTENEDSNGVVDQKTINQMKRIHNLVAILKECAGNEKEPLTLGKLKEINSDFIENFEE
Protein: WEE1 G2 checkpoint kinase (E9PRU3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Protein: Uncharacterized protein (D4AC54)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
AILCWPLGLSPTWLPEDGQVRLSIGQFCVAEHHNAVLSSFVEAKHSFLVFCRALTNAVYPRDHLIFALVVAGLVVRFPLVKQRAFHTVSEKTKAVITASIRAGWALLTRLPKGSRLCALALPTDATASVAADLPILGPARADVC
Protein: Annexin B22 (Annexin) (C4QH88)
Organism: Schistosoma mansoni (Blood fluke)
Subcellular location: Tegument {ECO:0000269|PubMed:24428567}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:C1L7Y4}. Host cell {ECO:0000250|UniProtKB:C1L7Y4}. Note=Mainly locates on the cytoplasmic face of the dual membrane of the tegument. Associates with the apical plasma membrane and its derivatives including surface invaginations. Localizes to vesicular structures, such as the elongate bodies, and to muscle layer, within the tegument. {ECO:0000269|PubMed:24428567}.
Interaction partners:
- Actin-2
- Peptidase S1 domain-containing protein
- Subfamily S1A unassigned peptidase
Sequence:
MANISGFGITRSLIHSFDPHGKHYRPTIKPTTGFSASADAERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKVLCQLIVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAIPDKGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYGKTLLEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDLQDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMGEIYNQQQ
Protein: Transcription factor PRE2 (Basic helix-loop-helix protein 134) (AtbHLH134) (bHLH 134) (Protein BANQUO 2) (Protein PACLOBUTRAZOL RESISTANCE 2) (Transcription factor EN 52) (bHLH transcription factor bHLH134) (Q9LXG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. Regulates light responses by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. May have a regulatory role in various aspects of gibberellin-dependent growth and development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH150
- Transcription factor IBH1
- Transcription factor bHLH148
- Transcription factor HBI1
Sequence:
MSSSRRSRQASSSSRISDDQITDLISKLRQSIPEIRQNRRSNTVSASKVLQETCNYIRNLNKEADDLSDRLTQLLESIDPNSPQAAVIRSLING
Protein: LOC560531 protein (Q0VA83)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
NCSGHKHTRPSVYTLYDSFLLRFWIFRRFKCVWSSGGDRCRMIPVVPVESCTHVLAEFDCLDPLLSALRLDSGRIKCTCLSVSRKWLALGTSAGGLHLIQRDGWKQKLILTHKEGSITQVSCCPHDEDFIAVATSQGLVVVWELHLERRGRPERASVSWEHRGVTVTSLCWDTVALRVFAGDMGGKVSCVRAGSSKLGKGSAFVIFPVQTVTTVDSRVVQLGYTDGHLVISSLSRCYLCDTEREKFWRVGNKERDGEFGACFLTQGLAGQRGQLVGCPAPLLFCARPGSRIWEASFSGEVLSTHQFKQLLAVPPLPLVSCKNEPHFNPTQTNPQSLAFPRLLQFGDQNLLTWTDSAIYIFTPHSGQVLLWTEVKDVLEISVFRNDLFCLHGDGHLSHMSLVSPDRCVERLMKRENWTIAATVCCMFQHAITTSKARKSLSIDRLEHLKAQLNSTSQQQLIGQLEEVISKLEPLDSACSSRRSSISSHESFNVLDCGIYRVISRRGSQSDDDASSLANQSMLEEERLKEFSFTEEEQVDNDSASVRGEGDRSDLGLQFLPLPFRSKPPRVALQAVRDSVSSFMKKTTEKINTLQMNADLWPRPDLREGVQGEVASTASPISEESEQELNTEESSSESELLELRAATKKAISQIQDPMVLLDPLCLSDVLQEWAPVLERALGPEDQILPVETTNPEEKTLEEEELVSSMSCCVVVQPEISTSPAADPDESATHTEEEDFRESTPCSIAPVRAQFPPLANHVELIQLFSPKPLPPDLQADLSLLACLYLEMGCPGRGGMESVCVFLRRFFFLLDQERVRRMCMLRYRENREVLKAYIAGMLEFTQASKVVEVIQKGDLLKSLRSLRELQPWNAPLLLSHLYRLYEKHGEVAVRAYPQFYPTILPSDIMAMALPSHFLPYLDNLVQSRAEQQRLSFLGSLLQPETLRQDWLELALSHDAPQREDTLTHDGQPRWHSHFFSWGYGRLLSLLIRLPADLASKQKMLDMCKAHGYWMGYLYLCRELQRRAEAFSAICRLDDMTLLEGDDGIVPQSLDEWVLLLQLSQQISASDESSLTSTKNSNGSCLDDANSNGDCSSGLSNGSTDWSIQVSPENIILRLVRVFGPDRALTALQEHGIPVDHSSRSTLVCDLLRMAEKRQRALIQSMLERCDRFLWSQHA
Protein: Probable transcription factor At4g01260 (Storekeeper-like protein At4g01260) (O04608)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAPKQLKKIENPVVSSSEEEESASSGESATSGEESDSSADSPVKESSKKPVVVSKPSGSKTTTKPESSTAAKRSFEKTDEMSKKKSKNSMGEEDVKKKDETLKKNLFVRLFTEEDEAILLQGFLDFATKKENPSDHIDDFYESIKNSISFDVTKPQLVTKIGNLKKKFNGRVSKGLKKGKNEEVMVFSKASDQNCFDLSRKIWGSNGVLYSKSKNMRQVQLGGSVKVDEDDQEPQKHRFVISTLSSGQELVSYLKVENPNSLGVDDTKWSAKLDKIKDGKQKRKMEKNLKKIQAKEEELSMMRSEFVAAVTNVLSKQDNASYSCK
Protein: Ras-related protein Rab-18 (EC 3.6.5.2) (Q54GY8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity).
Interaction partners:
- Rab GDP dissociation inhibitor
- Rab3 GTPase-activating protein catalytic subunit
- Rab3-GAP regulatory subunit N-terminal domain-containing protein
- Rab escort protein 1
- SNARE-complex protein Syntaxin-18 N-terminal domain-containing protein
Sequence:
MEEDKQYKVLLIGDSDVGKTSIVKRFSDDTFDEDLLCTIGVEFKMKEVKVDGKKVDLCIWDTAGQEKFRALISSYYRGAHGIILTYDVTKRESFDNLNYWLNEVENFANRSNLVKLLVGNKIDKENREVTREEGAEFAKKKAMLFIECSAKSKIGIQQAFEELAQKIIEIPQNTSSSQPKQRNTGSVKVEDEPDHNQGVCSC
Protein: Candida glabrata strain CBS138 chromosome H complete sequence (Q6FSG8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome D complete sequence
- Kinesin-like protein CIN8
Sequence:
MYRIKYRKLENITNKVSGNKEENTLERGLKRKQLNQLIRENEKFVRTDKNLQIKIDKYQRKDIPNLKYEVQKRTGLLSQLEKTVNQINLNFEALEKEKTALSSKNLAELTEIENKYKEVIEQKAAEFSQIFEKQQNAWREKIEELRNMPPEDELINQINNLKHTLSSTEQNLEDKIAKNDNDLILYKQKLQVSFSEYKKKNSTSLEELQSQSKNLESTMAELQNIKTEKNSQLRTLAEEQSELERIVMDKQLQVDKLNAEIEPVENKIKEYQNSFVLLKNDIEGMKIKAIDNEQQYNEVYDTLGEELSRRRRLLNSITELKGCARLFANIIEDEISEKLIVNYSDESIEDMKNHKTYKFTKLIQNFSHQNKDLFKEDLHVYIDFCLKRRENFNLFSVGSSNIPNTFEKLLAFFKNNYFDKFVITLQYVMLSDNADSQDLLSNNKDGGKDVEIKLKIEESTISLGSTLITLDEITDKLQIKKKYSQLNHQNGIGLSKFQFFCLQDIEPIPIDFYFIEIYQPSIYPILKRSTGTESNLNSPLEIVLKKIFHDTKSAFVFQIDHSAEVYDILKLSSHLSFIRNPKGK
Protein: DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) (Q61712)
Organism: Mus musculus (Mouse)
Function: May modulate protein synthesis.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
Sequence:
MWVPGFGSARLPQRRRSGLESSSVRPLWLLLLFLLAAVRPVRAWESGDLELFDLVEEVQLNFYEFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDVLINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLGRKKRERKKKTGSKSVDAAKLGASEKNERLLIKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETKLKEKEDALARIEIETLQKQKKVKVKKPKPEFPVYMPLENTYIQSYDHGTSIEEIEEQMDDWLENRKRTQKRQAPEWTEEDLSQLTRSMVKFPGGTPGRWDKIAHELGRSVTDVTTKAKELKDSVTSSPGMTRLSELKSNGQNSRPIKIATALPDDIITQREDSAGAMEDEEHEAAEGEQESATTEARPRRRKSARAAEAVTRVEPEEKLRGKRQKDFDISEQNDSSDEEKQRKERTRAAEEAWTQSQQKLLELALQQYPKGASDRWDKIAKCVPSKSKEDCIARYKLLVELVQKKKQAKS
Protein: RGG repeats nuclear RNA binding protein B (O23593)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds RNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SQ56}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O23523}.
Interaction partners:
- Large ribosomal subunit protein eL20x
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL20w
- Large ribosomal subunit protein eL20z
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL18z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein eS1y
Sequence:
MASVNPFDLLDDDAEDPSQIVASKPLKVVAPVQTAKSGKMPTKPPPPSQAVREARNAPGGGRGAGRGGSYGRGGRGGNNRDSRNNDGPANENGYGGGYRRSEEGDGARRGGPVGGYRGDRRGSYSNGGDSGDSERPRKNYDRHSRTAYGNEDKRDGAGRANWGTTQDDITPVTEESTAVVDKNLTVEKQDGEGEATDAKNETPAEKAEEKPEDKEMTLEEYEKVLEEKKKALQATKVEERKVDTKAFEAMQQLSSKKSNNDEVFIKLGTEKDKRITEREEKTRKSLSINEFLKPADGKSYYRPRGGYQGGREGRGPREGNQRDGGRNLREGGRNQRDGGAAAQAPTPAIGDSAQFPTLGK
Protein: Probable acid phosphatase DIA3 (EC 3.1.3.2) (Digs into agar protein 3) (P52290)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21
- Thiamine biosynthetic bifunctional enzyme
- Thiamine pyrophosphokinase
- Constitutive acid phosphatase
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20
- Acid phosphatase PHO12
- Acid phosphatase PHO11
- Repressible acid phosphatase
- Riboflavin kinase
- Low molecular weight phosphotyrosine protein phosphatase
Sequence:
MVKPVIFAICLGVLLSKALSIPLRSFADIELIGSQKSLFPFLGGSAPYFSFPANYGIPTDIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKISNYTGKYEGSLSFLNNGYEFFIPDESLLEMETTLQNSIDVLNPYTGEMNAKRHAREFLAKYGKLMENCTNFPIFTTNSKRIYDTAQYFAEALGDGFNISLQTLSENSSSGANTLAAKSSCPNWNSNANNDILMSYSRDYLENISDRLNDENKGLNLSRKDAAALFSWCAFELNAKGYSNICDIFSAAELIHYSYETDLTSFYQNGPGYKLIKSIGANLFNATVKLIRQSAHLDQKVWLSFTHDTDILNYLTTAGLIDDTRNLTTNHVPFRDHSYHRSWYIPQGARVYTEKFQCSNDSYVRYVVNDAVVPIESCSSGPGFSCEEGTFYEYAKDRLRGVSFYEDCDVSKVSKEKELTFYWDWNTTRYNASLVNQ
Protein: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (Q9NX45)
Organism: Homo sapiens (Human)
Function: Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9D489, ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250|UniProtKB:Q9D489}. Note=Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 expression. {ECO:0000250|UniProtKB:Q9D489}.
Interaction partners:
- Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
- Homeobox protein NOBOX
- Factor in the germline alpha
Sequence:
MASSIICQEHCQISGQAKIDILLVGDVTVGYLADTVQKLFANIAEVTITISDTKEAAALLDDCIFNMVLLKVPSSLSAEELEAIKLIRFGKKKNTHSLFVFIIPENFKGCISGHGMDIALTEPLTMEKMSNVVKYWTTCPSNTVKTENATGPEELGLPLQRSYSEHLGYFPTDLFACSESLRNGNGLELNASLSEFEKNKKISLLHSSKEKLRRERIKYCCEQLRTLLPYVKGRKNDAASVLEATVDYVKYIREKISPAVMAQITEALQSNMRFCKKQQTPIELSLPGTVMAQRENSVMSTYSPERGLQFLTNTCWNGCSTPDAESSLDEAVRVPSSSASENAIGDPYKTHISSAALSLNSLHTVRYYSKVTPSYDATAVTNQNISIHLPSAMPPVSKLLPRHCTSGLGQTCTTHPNCLQQFWAY
Protein: G2/mitotic-specific cyclin-B1 (E9PC90)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMVSQ
Protein: Papilin (Q5ZR40)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHLFLLFIPHVIAVKDLAWYSANPVLSSSHPVGPAAIQAATAIDFCQLPVDTGKCSQQLVRYYYDAAVDECKRFTFSGCGGNSNRFMRRAHCRNRCVKQPNKPEVQELKHRRTVTSTTSTPFQTVNEESTVEPSATKRLPVTLPVKKLELVQVRIFNKTESSFQSGHGNGLCQDCDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNGAVCGPNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVNLTEEDCNNGKQEIKYYYDADSVQCKQFFYGGCKTTSRNFFADLQTCDVICVSNQRDYLKSKGQSLSHHPVLEISSDLNNGNDLKSNHYKIDLFSSPSSPVTPNRPLSADDWPLKPITLKPALNLDFSQGKTKSTAEKHKEADDAEILVHQLTPEHNSCDLKFEPVLREECISADWAEKFFWNSEFKDCEPFWYDSSCDPRDRAGKNFFETFEDCKNKCDGVQSQYVVPITTVPDEQSKIEEVETSETPGIVDETTTTAAPEEESEENGFFFKVKPQNYLEDVLSSETEETQHYGFNPNEFLKQNSQNQKPTEITEILRILPAQTEHDEASELKKEDKIEHDILEHLKNKEPTEKVLSTPSTCDLEYDDALRNECTSADWTELYYWNAQFKECEAFWYDSSCGDQDFSKKNLFKNFDDCNNQCVKKIGEALKKMDPETTTTTSTTTTTTTAPTTTKMEEPKRSNYKQSDPLNLILNKALNPDESSELPEKFPPAHEQGFVNFAIKSEVTATTKFDRLKYMAEFRKLLALPDNFSTTPKQSSPTSSPTTTRMRSPSTHKSTVSQATKTASSTPQSPSTTTSFDDFVEKEKKTVLETIKILDRPEDLCDEPLHPKLEEDCKNDQWEIQWFFNSDRGACKSFWYGGCEIESRNFFPDHANCRHSCAHKYATPASFSSKVYIPPGELSTPVPPRKDRLTTSLKLTYPHSEDLFPSEEHSTVVELDGNFQRTEKQERIRLFPTKTFRPRAPTPTASNIVNVSEGEKTETAPAFYSHIDRVVHDMKTGEHPGYTKPEEFVRRIESASNDYIKYDLQKPDVVTIIDKSPPTVPSRKERTERTEVTTKLPSTRSINDPCDDEYDPKWDEDCLGDTWVVRSYYDSKAEKCKAFWYGGCHTSSRNIWFDKETCRTSCAHKFPTDMPMYGGAQSSEVSAEILPSPQEENSSKETSSSSSSSSSSNTAHISPEHRFKVDLDQKFADVKREHEGREDLAYSQMVQHPVTVSADCLEVYNASLSKPCGDGKSWSNRYFYDKDTRSCRMFWSNGCFSSSKNNFDDLETCQWKCEGRHPQPAGKSCLDKFDERYLEDCRHGEFTNRFYFDHDRKKCVAFHWGGCQSKSQNFFADMTVCQDLCESPPRELTQACLQPFDTTYETSCSAEKPQQYYYFDMSSGICKMFWFGNCKGENQNIFSTLEACQWICERKRDERKPAICADKFDTKYTESCGDSQWTEKWYFDQSSGDCSSFWWDECTSSSQNIFPDEKSCTSNCKHPGFEISSKLATEESKFRCLEPVEIGSCQETYPAFYYDRASRTCRPFAYSGCGGNSNRFMTVSQCENLCFAFNSMNEAEVDCHLPMHIGYGKNEDSCLPQAGFRFYYDRNYGKCSQMWYLGCGGNANNFYSYEICQRTCSQSDVPRELERKTRASSEVCFEPPGDRGICGKNSSTNPLKRWTYGNQKCTSFTYSGCGGNRNRFATQDICENTCNGLMNSNDPRICSFSPDWGSCNQLRYVWFYNLTRGTCDQFLYGGCGGNPNRFDTFEICQKACEVTGTDPCMESLDRGSWCEAMSNRYYFNKRARQCKGFHYTGCGKSGNNFLTKEECQTKCEKRFPRAAPSKKKAKVKLPVGYSGAKPKDKTPMLRHINLNGNNQTYFKSEPQWMDYSSCYGYRYNVTGRDTILNVHYCAIRGSADCISESYRSTEGEEYCNILRPFLRGQNLYSFYFGLDSVNPMYRPKDGLSGRIQRKNETIAAVLVLKANQCHEIC
Protein: Kinesin-like protein KIF3B (F1QN54)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation. Required for photoreceptor development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61771}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61771}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61771}.
Interaction partners:
- Kinesin-like protein
- Kinesin-associated protein 3b
- Intraflagellar transport 88 homolog.
- Intraflagellar transport protein 20 homolog
- Kinesin-associated protein 3a.
- Intraflagellar transport 52 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport protein 56
Sequence:
MSKSKSSESVKVVVRCRPMNEKERVANFNRVVSVDVKLGQVAVCNPRGASSHEHPKVFTFDSVYDWNSKQMELYDETFRPLVDSVLFGFNGTIFAYGQTGTGKTYTMEGVRNDPERRGVIPNSFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQARRLELKERPDTGVYVKDLSSFVTKSVREIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSELGPDGENHIRVGKLNLVDLAGSERQTKTGAQGERLKEATKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNARTVMVANIGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKEQLEKRSGRKRRRRRRRRVGEGGEEFEDGEDEEDDDDDDEDEEEGVDADKNIADYWHEQQEKLEKERRAIMEDHSLVAEEKQRLLKEKERKMTDLHKEKEASEMLTAKVKAMESKLLVGGKNIVDHTNEQQKVLELKRQEIAEQKRREREMKQEMECRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQSVKSEIQDAQDEHVKYRQELEQTQNELTRELKLKHLIIENFIPMEEKNKIVTRATFDEEDDLWKMTPITRIQNSDHQMMKRPVSAVGYRRPLSQHARMAMLMRPDVRYKAENILLLELDLPSRTTKDYEGPVIAPKVAAALEDALREEDEIQVDASGFHASLGSSPGLSASAAGFSKKPKSGRPKTGKKVSTPTSAHSPLSGSGSPLYPQSRGLVPK
Protein: Folliculin/SMCR8 longin domain-containing protein (Q580K5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQTVWNVPAVILGEFDAIEGPKDLHVTEYYEYQEMNSFGAQMPQLSAFHGKALFSAHSISGSLRPHSKQKMRELVARVLDSNESNEESVVMSDPDAGGVSGIAFCLGDILARGESRRFCVIITHPRSDELIRRWPVLSCFMRILLEGWVDVTERRLASEYSTFPDLERRREEARKRPMRPLMSLLAEDDEAEADAFRRTHNFFECVLLALFGRTPLIPEEPTCETAVLNTVKQYLEMKLPLVETIDVDVGWPPEIGRCVSLGDSRVVSLGPFHLLKPLSVWLLVFLEWSDTGLDETELLLSALLRGKQIVVYGADNIHCAGLAISLSQILPRSLRSVSVFSEKYRLPCESRILSFNTPVRLGTLIEMTRQTNAGVPHSDVVCVNVDDSGRIVSIHNYGACGRGSDTDKPHAYHKIGDVSRSSVVKQFTNLLRSHMFVPAAARTCKKLQFHIEQLVVETVLRGRLYAELFQEGATRITNKDSLCSGKRRTSYRHSRPIWHRLFDFFLGDYCLPSSRLASVESSCNANFFSGDTGAVFVDSGGRVEPNSMVNSSYDHDALIFLGSA
Protein: Putative ubiquitin thioesterase otu1 (EC 3.4.19.12) (Meiotically up-regulated gene 141 protein) (OTU domain-containing protein 1) (O13974)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cell division cycle protein 48
- UBX domain-containing protein 3
- Ubiquitin fusion degradation protein 1
- Ubiquitin homeostasis protein lub1
- Nuclear protein localization protein 4
- Ubiquitin conjugation factor E4
- Polyubiquitin
- Ubiquitin thioesterase otu2
- Ubiquitin carboxyl-terminal hydrolase 14
- Probable ubiquitin carboxyl-terminal hydrolase 4
Sequence:
MSSLRLRLKYENQSAVETVEANATVGSFLDLVAAKFSLPRNSIALKFGFPPQDIPLVNSDVPLSTLVSSGQQILVLKNAATSFSTNEPAKPPIPNAATKPTFPPQTEISNPPAVSHQSKNTSQDPPYVSTPIGDIALRVMPDDNSCLFRALSKPLGFSPYELREIVANQVLSNPDIYSTAILGKPSIEYASWIRKETSWGGYIELSILSSHFGVEICSVDVKTGRVDSYNPQPATGQRTYIVYSGIHYDLAALAAVLWDTDVDVVLFDASDVTITPYVQQLASLLKNMHYYTDTASFSIRCTICGTGLVGEKDATAHALATGHTQFGEY
Protein: Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) (GABAAR subunit epsilon) (P78334)
Organism: Homo sapiens (Human)
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular location: Cell membrane; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Huntingtin-associated protein 1
- Inactive phospholipase C-like protein 1
- Trafficking kinesin-binding protein 2
- Vesicle-fusing ATPase
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid receptor subunit beta-1
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit alpha-2
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit theta
Sequence:
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETETGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLNL
Protein: Nucleoside transporter (Eurofung) (Q5B1T7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MANENVLEGVPPRESPQPQDFIRHSNGHAPPAISSDNHSSYAQEAFAEKKAIPESHPLDNSSEPSGQDVEAGRKAAFKSAARRYYKSYFKHVLYAVIWLLFTGWWIAGLILHRYDLGWLVPFLLYLVITLRLIFLYVPISIFTRPVHWAWKSTASRLVSMIPEHFRIPLGALVTIATILVGSFASAEAPGNTRADRAVSLFGLLVCIFCLWLTSRNRRKVNWHTVVVGMLVQFIVALFVLRTQVGYDIFDFISMLARELLGFAQEGVDFLTTTDFESGHPYFLVTVIPAIIFFVSLVQLLYYTGVLQWAIRKLAVFFFWSMRVSGAEAVVAAASPFIGQGESAMLIKPFIAHCTMAEIHQIMCSGYATIAGSVLVSYLSMGVNAQALISSCVMSIPASLACSKLRWPEEEETLTAGRVIIPEETEDRPANLLDAFSKGAWLGIKIAGMIAATLLCIISLIGLIDGLLTWWGRYLNINNPTLTLDLIVGYICYPIAFLLGVSRDGDLLKVGKLIGLKLVANEFVAYSALQTDPQYQDLSNRSRLIATYALAGFANIGSLGNQIGVLAQLAPSRGGDVSRVAVSAMLTGAISTFTSAAIAGLLIQNEEQYMTTATS
Protein: Alpha globin 1 (Alpha globin 2) (Alpha-globin) (Globin c1) (Hemoglobin alpha, adult chain 1) (Hemoglobin alpha, adult chain 2) (Q91VB8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVLSGEDKSNIKAAWGKIGGHGAEYGAEALERMFASFPTTKTYFPHFDVSHGSAQVKGHGKKVADALANAAGHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLASHHPADFTPAVHASLDKFLASVSTVLTSKYR
Protein: Insulin-like growth factor I (H6U4T4)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MEKINSLSTQLVKCCFCDFLKVKMHTVSYIHFFYLGLCLLTLTSSAAAGPETLCGAELVDALQFVCGDRGFYFSKPTGYGSSSRRLHHKGIVDECCFQSCDLRRLEMYCAPIKPPKSARSVRGPRHTDMPKAQKEVHLKNTSRGNTGNRNYGM
Protein: Calpain-like protein, putative (Q4GYZ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGCGGSTTSVTFINGRPTVQGDEIAKGFNEGNGLLFRIVNSSTGRWAYYNDTLDYDMHVKVTFSEDCKIKALGKAKLERLSSGESVVTVVVKPCATELFIEGTVNGYKAKMDAIPITDGDRRRRGSGRK