wanglab/gogpt-training-data huggingface dataset:
Protein: SAGA-associated factor 29 homolog A (AtSGF29a) (29 kDa SAGA-associated factor homolog A) (Q8RXY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chromatin reader component of the transcription regulatory histone acetylation (HAT) complex SAGA (By similarity). Involved in salt stress tolerance. Enhances the effect of ADA2B in the positive regulation of salt-induced gene expression.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA-associated factor 11
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Transcription and mRNA export factor ENY2
- Ubiquitin C-terminal hydrolase 22
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Transcription initiation factor TFIID subunit 6b
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 12b
Sequence:
MSSSPDIAGILDNTKELDRLRKEQEEVLVEINKMHKKLQATPEIVEKPGDISLSKLKNLYIQAKELSESEVTVSNILLTQLDSLLPSGPTGQQRRKLEGNEQKRKRMKVDTDVTRVSPSMRNQIEAYASLKGEQVAARVTAEDAEKDEWFVVKVIHFDRETKEVEVLDEEPGDDEEGGGQRTYKLSMSCILPFPKRNDPSSTQEFIPGKHVLAVYPGTTALYKATVISTPRKRKSDEYLLEFDDDEEDGALPQRTVPFHKVVALPEGHRQ
Protein: Collagen alpha-1(XIV) chain isoform X3 (Collagen, type XIV, alpha 1a) (F1R9Y1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MQVSGSRIKLWCPLISLALIQFLAPVSAQVPAPRRLRFKVVSAGKLLVSWKEPKGEYNGYRFIYNTEPGGETSELQIAKGVNKAIIKEFNPRKEYSVKVIAVSGNLQSRALQGKYTEDQSSDGEITQPQRLKEPGAVEEGNEISAVDQFVCTTPAIADIVILVDGSWSIGRINFRLVRMFLENLVNAFDVGIDKTRIGLAQYSGDPRIEWHLNGFSTKEAVIDAVKNLPYKGGNTLTGLALTYVLENSFKPESGARDNIPKIGILITDGKSQDDVISPAQTLRSSGVELFAIGVKNADENELKAIASEPEDTHVYNVADFSIMGTIVEGLTRTVCDGVEQQDKEIKQDSVPEETVSTPLNLLISEVTAHSFRVSWTHSAGKVEKYRVVYHPTDADIPEEIVVGGLENSVVLQNLNSLTEYEIAVFAVYRSAASDALRGSEITQALPTVSDLELYDVTDSSMRARWRDAEGASGYMILYAPLSSDTPDERELKVDETVTDVELTGLIPDTEYTVTVYATFGEEASDPATVQETTMSLKPPRNLRVTEVDHSSVRLNWDSASSKVKGYQVIYVKTDGVQTNQVELGPVTNVYLKNLSPLTEYTVAVFAVYDGGQSEALSGGFSTKLVPAPFSLMTSDVTSESFQVSWSHPARDVVLYKLIWSPTAGRDEREVMLAGDTDSYVIQDLSPFTEYKVSLAAIYKDETESSPVVVLEYTLGWTTEFPTTIPTTTPIFHQGVTNLWIDEETPFSIQVNWEVQDSDVDQYKVTYVSTDRTEETVLVSGNRRNVVLQPLLSDTKYKITVTPVYADEESSQLSMSSFGTTLPLSGPSNLRVSDEWYNRFRISWDSPQFPTMGYRVIYQPISVSGRALETFVGDDVNTLLILNLLSDTEYSVQVIASYTTGSSQPLTAKGKTLFLGVRNLNTYQVLSSSVCAQWQPHRHASVYRVVIESLHNGQKQEVRVGGGASRECFFRLSPNTQYKISVYTVLQDTEGPAVTTMVTTALAPTQPPTAAPTTSPPPTIPPAKEVCKAAKADLTFLVDGSWSIGDDNFQKIIRFLYSTTGALDVIGPEGTQVAIAQFSDDARTEFKLNSYSDKEALLDAVQRISYKGGNTKTGRAIKHVKEAIFSEDAGVRRGIPKVLVVLTDGRSQDDVNKISKEMQMEGYIIFAIGFADADYGELVNIASKPSERHVFFVDDLDAFKKIEEQLITFVCEAATATCPSVLMSGNTLAGFRMMEMFGLAEKHYSSVQGVSMEPGTFNSFPCYRLHKDALVSQPTRYLHPEGLPSDYTISMLFRILPETPQEPFALWEILDKNNEPLVGIILDNGGKTLTFFNSDYKGEFQTVTFEGPEIKKIFYGSFHKLHVAISKTAAKVVIDCKTVGEKSINAAGNISIDGVEVLGRMVRSRGRKDNSAPFQLQMFDIVCSTSWASRDKCCELPGLRVEEDCPAMPHACTCAQDSKGPPGPSGPPGGPGIRGSRGDRGEPGLTGSQGLPGEIGPPGPQGPPGPQGPNGLSIQGPPGAPGEKGDKGEIGLPGPQGVPGANGGPGRDGPPGQRGLPGKDGPQGRQGPPGPMGSPGAPGAPGSNGPPGQLGDQGPPGPAGTKGERGERGDMQSHAAVRAIARQVCEQLIQSHLSRYNSILNQIPSQSVSVRTVPGPPGEPGRPGLQGPQGEQGPPGRPGFPGASGQNGRPGERGLPGERGEKGSPGVGTQGPRGPPGSPGPAGEGRTGSQGPPGRPGIQGTQGRPGTPGSPGPAGPPGYCDQNSCLGYNVGVQQLSSNPYQNYGPATNYNPEDEEEDDPYGGYRAYPPQYYQPSYPDPRGARPGPVHPGDTAGMRAPGARRFTRSTAEEGIVHQPQEHVKEEELW
Protein: Transmembrane channel-like protein 5 (Q6UXY8)
Organism: Homo sapiens (Human)
Function: Probable ion channel.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSAYYRNNWSEEDPDYPDYSGSQNRTQGYLKTQGYPDVPGPLNNPDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDFAGSSSSGNYAGSRTHPDHFGSLEPDYPGAQSNSDHPGPRANLNHPGSRKNLEHTSFRINPYADSLGKPDYPGADIQPNSPPFFGEPDYPSAEDNQNLPSTWREPDYSDAENGHDYGSSETPKMTRGVLSRTSSIQPSFRHRSDDPVGSLWGENDYPEGIEMASMEMANSYGHSLPGAPGSGYVNPAYVGESGPVHAYGNPPLSECDWHKSPQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA
Protein: Transmembrane protein 163 (Synaptic vesicle membrane protein of 31 kDa) (Q8C996)
Organism: Mus musculus (Mouse)
Function: May bind zinc and other divalent cations and recruit them to vesicular organelles.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17623043}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:A9CMA6}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Note=Glutamatergic synaptic vesicles. {ECO:0000250|UniProtKB:A9CMA6}.
Interaction partners:
Sequence:
MEPALGSERRSPPGPGVPRPPPRGHAPSTAAPAPSPAPMSSSVQSDEERQPRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWLSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSANREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSVLAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHNAAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE
Protein: Probable conserved transmembrane transport protein MmpL13b (O06546)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Probable conserved transmembrane transport protein MmpL13a
- Conserved protein
- Mce-family related protein
- Anti-sigma-L factor RslA
Sequence:
MATVAFVATASIVITPAAIVLLGPRLDALDVRRLVRRLLGRPDPVHKPVKQLFWYRSSKFVMRRWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDFGHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGSWVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVVMAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVCNVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMDYEVFLVSRIREYWLESGAARPARRSVAEVHAANDESVALGVARTGRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVPAFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGGLGKIAGRSDGQTIPASLTRNG
Protein: Glucan endo-1,3-beta-glucosidase btgC (EC 3.2.1.39) (Endo-1,3-beta-glucanase btgC) (Laminarinase btgC) (Q5B430)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Rho GTPase activator Rga
Sequence:
MGDRSEQYGDIPPISSQHRMHGYGNNGEPAAMPGDGQQNWGSGPGIAHTHSMRTASTATPGMDNLGPSAVGGGISGIALGVANTHDRQSGIDAFRDADATLGYIPAERGYHTTGADNPYVPSPPSVGPGPDESSEGLRSHETFGSSAALSAAGAPAGNWTPPSGSRHSFLDGSYQGVASGPYQRHSAYSSQDYPADINPDDILDDGDDGFAAAPSNKPNAAGGAATGGAAGGLLGEFFGAKKAADASYDPVPGAGLPSVEKYAKPRPSGASRKRGWIIGGILAFIVIGAIVGGAVGGTLGNRRSETASESSEVSADDDTETNGDLDKNSDEIKSLMAMEGLHKVFPGMDYTPWGVQHPECDKWPPSQNNVTRDMAVLSRLTNTVRLYGTDCNQTEMVLHAIDRLELTDMKLWLGVWIDTNTTTNERQLSQLYDILDKRSDHSVFKGAIIGNEALYRAGSTKEEARKNIIDYMRQVRKHFNDHNIDIKVATSDLGDNWDETLADATDVVMSNVHPFFGGVEVSKAAGWTWSFWNSHNAPLTQGTNKGNIIAEVGWPSGGGNDCGDGANCKDDTSGAVAGVKQMNQFMADWVCPALENGTDYFWFEAFDEPWKVKFNKGDEQWEDKWGLMDPGRNLKPGIEIPDCGGKTAA
Protein: Carnosine dipeptidase 2 (J3QLU1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDG
Protein: Uncharacterized RNA-binding protein YGR250C (P53316)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- RNA-binding protein SGN1
- PAB1-binding protein 1
- Negative growth regulatory protein NGR1
- Nuclear cap-binding protein subunit 2
- Eukaryotic initiation factor 4F subunit p130
- mRNA 3'-end-processing protein RNA14
Sequence:
MNIAEEPSDEVISSGPEDTDICSQQTSASAEAGDQSIKIERKTSTGLQLEQLANTNLLTIRIKWQLQEEEDDHCNSRITDQIMDTIQHYKGISVNNSDTETYEFLPDTRRLQVLEQNKDIYLYEHGSQEYEKSYKDNEEEDDWRYDTVLQAQFKYPKSLENACTDISELLKSEPIGQHIDKWSIGVNKHALTYPGNIFVGGIAKSLSIGELSFLFSKYGPILSMKLIYDKTKGEPNGYGFISYPLGSQASLCIKELNGRTVNGSTLFINYHVERKERERIHWDHVKENNNDDNFRCLFIGNLPYHNPEKVETLITPKEVIEVIKKELSKKFPDFDIISYYFPKRSNTRSSSSVSFNEEGSVESNKSSNNTNGNAQDEDMLKGYGFIKLINHEQALAAIETFNGFMWHGNRLVVNKAVQHKVYNNHNSHDRHPSISNHNDMEVLEFANNPMYDYNNYTYDRYYFNNNKNGNSNDTSNVRYFDSVRSTPVAEKMDLFYPQRESFSEGRGQRVPRFMGNKFDMYQYPSTSYSLPIPMSNQQESNLYVKHIPLSWTDEDLYDFYKSFGEIISVKVITVGGSKNKYRQQSNDSSSDNDLPVGSSRGYGFVSFESPLDAAKAILNTDGYQVSKDQVLSVSFAQKRGNLSSSDDDDQSQTDNSSKFQNFQPHNDYHKAYPTKYNKKFINALMTQNQSQQQVSRENYFIPLQYPNTNTKPVNSYNLISANQNNANWMMPMFPSFGFIPQVPPVPYIIPPQNPAANHIPIMANGSNEEEEFSSGDYSMDY
Protein: Interferon alpha and beta receptor subunit 1 (A0A8I6AH72)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEADVKIPLCVFTGEDNLRPPEDVAIYIIDDNYTLKWNHHRESMGNVTFSAEYQKGEGRIWLKVPKCQHITRTKCEFSLLGINVYSKTQFRVRAEEGNSTSSWNEADSFIPFYKAHVSPPRVHLKAEDKAILVYISPPGEDGTMWAQEKRCFNYTIRIWGRSFPVREIKPMYFPKKISKLLPETTYCLEVRAVHTSLQRHSNYSSARCINTTVANKIPVPENLEVDVQGDSYVLKWDHAFANMTFKAQWIPVYSKSSPGNHSDKWKPIPTCANVQTTHCVSPRETFHTGTFFLRVQASDGNNTSFWSEEKLIDSQKYTLLPPPVIAVTPTGDSLLVYVSCKDSKCNGLIYEVIFWENTSNTEKRQHPQSMIKEHPEFNVVNLRPLTVYCVQARVLSTGVWNKTSKFSDKLCKKTHPGNSSVTWIITGFGALLFSAMAFYAGRSLQKYLYYVFSPPLKPPCSIDEFFSELPSKSLLLLTAEEHTERCFVIENTGVVAGEENRAPEEELRKYSSQSSQDSGNYSNEEEESVGPESGQDMLSTAPSGSPWSLPCPAGTLEDGACFPGKEKHLQSPVLRTQPALHG
Protein: HCG37614 (ZNF697 protein) (cDNA, FLJ92048) (Q8N508)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTLTQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC
Protein: GATA-type zinc finger protein with TIFY domain-containing protein (F4JQX4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00357}.
Interaction partners:
Sequence:
MFGRHSIIPNNQIGTASASAGEDHVSASATSGHIPYDDMEEIPHPDSIYGAASDLIPDGSQLVAHRSDGSELLVSRPPEGANQLTISFRGQVYVFDAVGADKVDAVLSLLGGSTELAPGPQVMELAQQQNHMPVVEYQSRCSLPQRAQSLDRFRKKRNARCFEKKVRYGVRQEVALRMARNKGQFTSSKMTDGAYNSGTDQDSAQDDAHPEISCTHCGISSKCTPMMRRGPSGPRTLCNACGLFWANRGTLRDLSKKTEENQLALMKPVSSYKYHPDDGGSVADAANNLNTEAASVEEHTSMVSLANGDNSNLLGDH
Protein: At5g37840 (Plastid movement impaired protein) (Q6NL13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g61920
- At1g64700
- At3g03280
- 6,7-dimethyl-8-ribityllumazine synthase
- At3g10120
- Emb|CAB85509.1
- 6,7-dimethyl-8-ribityllumazine synthase
- Uncharacterized protein At5g17350
- Uncharacterized protein At5g66580
- DUF4228 domain protein
Sequence:
MGNTIMVRRNKVKVMKIDGDIFRLKTPVTASDATKEYPGFVLLDSETVKRLGVRAKPLEPNQILKPNHTYFLVDLPPVDKRNKLPYRRVMSGNIHVGAKERLEMLMLSRRTVSDVGAARSDVVGDGPELGHTRVRLRLPRSQITKLMEESHDASEVAAKIISAYMESSGGIQGGRDNDGLRQRLGIAEINNHYKAREKHVSFAEKGGRGEIVVL
Protein: Cell division protein ZapD (Z ring-associated protein D) (P36680)
Organism: Escherichia coli (strain K12)
Function: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01092, ECO:0000269|PubMed:22505682}. Note=Localizes to mid-cell in an FtsZ-dependent manner. Localization does not require FtsA, ZipA, ZapA or ZapC.
Interaction partners:
- Dephospho-CoA kinase
- Cell division protein FtsZ
- Cell division protein ZapC
- Cell division protein ZapB
- Cell division protein ZapA
- Cell division protein FtsN
- Cell division protein ZipA
- Cell division protein FtsA
- Nucleoid occlusion factor SlmA
- Septum site-determining protein MinC
Sequence:
MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC
Protein: Protein phosphatase 1 regulatory subunit 12A (H0YIM2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRVTGKSQYLLGGTKSSRKKNI
Protein: Formimidoylglutamase (EC 3.5.3.8) (Formiminoglutamase) (Formiminoglutamate hydrolase) (Q9HZ59)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Interaction partners:
- Imidazolonepropionase
- Formimidoylglutamate deiminase
- N-formylglutamate deformylase
- Bifunctional protein PutA
- Sodium/glutamate symporter
- Glutaminase
- Urocanate hydratase
- HTH-type transcriptional repressor AllR
- Glutamate dehydrogenase
- Histidine ammonia-lyase
Sequence:
MYPAPDMSLWQGRIDSQEGADARRWHQWMRPYADDAEAASVLLGFASDEGVRRNQGRQGARHGPPALRRALANLAWHGEQAIYDAGDIVAGDDLEAAQECYAQRVADLLACGHRVVGLGGGHEIAYASFAGLARHLSRHERLPRIGILNFDAHFDLRHAERASSGTPFRQIAELCQASDWPFAYCCLGISRLSNTAALFDQAQRLGVRYLLDRQLQPWNLERSEAFLDGFLQSVDHLYLTVCLDVLPAAQAPGVSAPSAHGVEMPVVEHLVRRAKASGKLRLADIAELNPQLDSDQRTARIAARLVDSLVN
Protein: Uncharacterized protein C4B4.12c (O74973)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MVSGNDQQVIEYTSVLKEFSDGVDLMELKENFLYIRTREKIEAKLIWAGEWEWKPVNETNENNLERGRQYPSANSALMENSPEFAKWFHGQLFNRLCVLGSTSSSRKDML
Protein: DNA-binding transcriptional activator EvgA (P0ACZ4)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor protein EvgS
- HTH-type transcriptional regulator YdeO
- Two-component-system connector protein SafA
- HTH-type transcriptional regulator GadX
- Transcriptional regulator GadE
- Transcriptional regulatory protein PhoP
- HTH-type transcriptional regulator GadW
- Protein YdeP
- Sensor protein PhoQ
- Probable multidrug resistance protein EmrK
Sequence:
MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG
Protein: Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2) (P22057)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
Subcellular location: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P41222}. Nucleus membrane {ECO:0000250|UniProtKB:P41222}. Golgi apparatus {ECO:0000250|UniProtKB:P41222}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P41222}. Secreted {ECO:0000250|UniProtKB:P41222}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. {ECO:0000250|UniProtKB:P41222}.
Interaction partners:
- Hematopoietic prostaglandin D synthase
- Prostaglandin E synthase
- Prostacyclin synthase
- Prostaglandin G/H synthase 1
- Thromboxane-A synthase
- Prostaglandin E synthase 2
- Prostaglandin E synthase 3
- Prostaglandin G/H synthase 2
- Prostaglandin E synthase 3
- Prostamide/prostaglandin F synthase
Sequence:
MAALPMLWTGLVLLGLLGFPQTPAQGHDTVQPNFQQDKFLGRWYSAGLASNSSWFREKKELLFMCQTVVAPSTEGGLNLTSTFLRKNQCETKVMVLQPAGVPGQYTYNSPHWGSFHSLSVVETDYDEYAFLFSKGTKGPGQDFRMATLYSRAQLLKEELKEKFITFSKDQGLTEEDIVFLPQPDKCIQE
Protein: Tektin-3 (Q4V8G8)
Organism: Rattus norvegicus (Rat)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A6H782}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:19423663, ECO:0000269|PubMed:21744413}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000269|PubMed:21744413}; Peripheral membrane protein {ECO:0000305}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (By similarity). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (PubMed:21744413). Not detected in the central axonemal region of the flagellum (PubMed:21744413). Associates with the acrosome membrane in the equatorial segment of the sperm head (PubMed:21744413). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (PubMed:21744413). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q9BXF9, ECO:0000269|PubMed:21744413}.
Interaction partners:
- Tektin-2
- CD164 molecule like 2
- EF-hand domain-containing protein 1
- RIB43A-like with coiled-coils protein 2
- Meiosis-specific nuclear structural protein 1
- Cilia and flagella-associated protein 52.
- Tektin-4
- Sperm associated antigen 8
- Tektin-1
- Protein Flattop
Sequence:
MEPLGSTLTATYAHPQPAATNFLPAIGTLTSSYRNRFPHRNLTHSLSLPWRPSTYYKTAYNYPTLAPLSSTSQSVCESTMLPFVSNRTTLFTRYTPDDWYRSTLVGFQESNCSRHNSERLRVDTSRLIQDKYQQIRKTQADSTQNLGERVNDIAFWKSEIIHELDEMIGETNALTDIKRRLERGLIETDAPLQVARECLFHREKRMGIDLVHDEAEKELLTEVETVLCCQERMRRHLDKAIAQLASDRSAQHELEKDLSDKQAALRIDDKCKHLRNTSQGVSYFRGVENVDATVSVPESWAKFTDDNVLRSQSERAASAKLREDTENLLIVIANEMWNQFNKVNVAFTNRIAETVDAKNKIHIHLSKTLQEIFQTEMAIESIRKAIKEKSAFLKVAQTRLDERTRRPNIELCRDIAQLRLVNEVYEVDETIQTLQQRLRDSEDTLQSLAHTKATLEHDLAVKANTLYIDQEKCMSMRNSYPSTLRLVGFC
Protein: Protein-lysine N-methyltransferase rrg1 (EC 2.1.1.-) (Elongation factor methyltransferase 2) (Rapid response to glucose protein 1) (P40389)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 2 and elongation factor 3A.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Vacuolar protein sorting-associated protein 28 homolog
- Lipid-anchored plasma membrane protein uvi15
- Protein-lysine N-methyltransferase efm4
- Protein-lysine N-methyltransferase efm3
- UV-induced protein uvi31
Sequence:
MILEDTDLPLSHEQPSYSQIKDVLDKIPTGEHLWDLPKYEEKIILNWLIKLLATNLEWITVEEERDYLVSTICERIAERSGRLAAPTRKREFSLSNGVSVVLREPTMTYNTLGFKTWGSAPLLSANLPKWEDLSNSINALELGAGTGLVGISAAIQLGWQVVCTDLPDIVENMQYNVDYNSELIQQYAGSVSCHVLDWMNPPDDDNRPSWLIKPFQRIIASDCIYETHFGELAIALFRKYLAKDGIVITEYPLRETHLEEIGVFEKGMDAAGFERQMGEEIGEEDFGSLYPVTCRWSRWKYHG
Protein: Methyltransferase domain-containing protein (Q93574)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MESSKFDEVVSKYRRILNSRSIEYFASSSWDLLEDEWREYLNLESLEDVIVFVNSSDNLVSADCASIPHSLRDLKANLKLFEYNRKCVENPSDLWRQWTGTTRDGLNASFRTISSANGLVRKRIKAKKQHEIDRIVELISQIQIFQKDSADPIDSLVDIGAGIGHLSRMISIHNNISVMAVEGNQQFTLAANSLDEKLLLDSAKIGSRIENFNVKSTPIRYTNFVTEDLALKIDDFAVNSAILVGLHCCGDFSSTILKVFQKSEKSKALVLFGCCYHKEFQCFHFLRPENNENEREISENTSFGKSTVFPLSKKWENVEIDYLLREAACHNNENLEERFLKQKIDLSRYARSYLEKWIWKVSELPEDRNIGMCSVKCIENQTTFEEYIRKAMANRGNHLLDKVLQIIPQSELSAHVSSLRSSQFDSFEVLRCMFAPAIESAIIDDRVELLRENGINSRVVPLFEPSISPRNLAIIAYK
Protein: Actin-8 (EC 3.6.4.-) (Q96293)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Actin-related protein 4
- Actin-related protein 2
- Profilin-1
- Actin-related protein 2/3 complex subunit 3
- Actin-interacting protein 1-2
- Profilin-2
- F-actin-capping protein subunit beta
- Actin-related protein 9
- Chromatin structure-remodeling complex protein SYD
- Tubulin alpha-2 chain
Sequence:
MADADDIQPIVCDNGTGMVKAGFAGDDAPRAVFPSVVGRPRHHGVMVGMNQKDAYVGDEAQSKRGILTLKYPIEHGVVSNWDDMEKIWHHTFYNELRIAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFSLPHAILRLDLAGRDLTDYLMKILTERGYMFTTTAEREIVRDIKEKLSFVAVDYEQEMETSKTSSSIEKNYELPDGQVITIGAERFRCPEVLFQPSFVGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFSGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKAEYDEAGPGIVHRKCF