wanglab/gogpt-training-data huggingface dataset:
Protein: Death-associated protein-like 1 (Early epithelial differentiation-associated protein) (A0PJW8)
Organism: Homo sapiens (Human)
Function: May play a role in the early stages of epithelial differentiation or in apoptosis.
Interaction partners:
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL15
Sequence:
MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC
Protein: Leucine efflux protein (P76249)
Organism: Escherichia coli (strain K12)
Function: Exporter of leucine. Can also transport its natural analog L-alpha-amino-n-butyric acid and some other structurally unrelated amino acids. Leucine excretion is probably driven by proton motive force.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Inner membrane protein YtfF
- Aromatic amino acid exporter YddG
- L-alanine exporter AlaE
Sequence:
MFAEYGVLNYWTYLVGAIFIVLVPGPNTLFVLKNSVSSGMKGGYLAACGVFIGDAVLMFLAWAGVATLIKTTPILFNIVRYLGAFYLLYLGSKILYATLKGKNSEAKSDEPQYGAIFKRALILSLTNPKAILFYVSFFVQFIDVNAPHTGISFFILAATLELVSFCYLSFLIISGAFVTQYIRTKKKLAKVGNSLIGLMFVGFAARLATLQS
Protein: DEAD box protein 21E2 (LD21669p) (Q9VPT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- rRNA methyltransferase 3, mitochondrial
- EG:8D8.4 protein
- Large ribosomal subunit protein uL4m
- Something about silencing protein 10
- FI04466p
- Mitochondrial assembly of ribosomal large subunit protein 1
- Large ribosomal subunit protein bL9m
- Pescadillo homolog
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL38
Sequence:
MLNLSVVLRVQSSRHVASYATAAAAAVKTKPPKAKSKGKKQKGEPLISCRRSQFDLTQYEQTDAKFGSLSLASKGWLHNKSKGDFFILNASVRGEELQQEMQTVDEFLESTGMQIHPQLLENLRVELGIKLLTGIQKQGMPVVHGNEHCLIAAETGCGKTITYLLPIVDKLLQKEVVTERKLNTPRVLILTPGRELATQIAGVTEKLTQGTNLKVQSLLGGNTKQLMMNPQFEEVDILVATLGALSKLVTTGIYRMEQVRHLVLDEADTLLDDTFTDKLSYFLRRFPFHLVQKEDAGTQMILASATMPTNTREILHKVIDVDTIREVVSPHLHRLMSHVTQKFLRLSKADRPATLLSLVKHDLAKRRPLIVFSNKSTTSDFVSIFLNNSGVNCLNLNGDMLMKIRLGRFEQFQNGHCDVLSTTDVGSRGLDTTRARHVVNFDFPLHVSDYIHRCGRIGRVGNMDKALVTNLISSRREIDVVQRIEHAARTGGLLPDVNANIRNIINKRIVAEMKAAGMPVPALGSLNGHTPQEEAF
Protein: Uncharacterized protein (Q38B46)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVLYVMGPPRGRGGANTSRPIIAVLADVSFDTFRVRVLCIESIVNRPMAFTALKNTYCDAYNPTSSGPFLSAGNSDSLMDLTVDDKKQELGALKGFQASPPSALGSVLIDIPLDTSHMSPDDFMSIAFSPRCNPLGSFHRLSVSAPLVKAAYIHDYVIHGPDSPGRNDFIRAMERRGSATRRDTSTRSVSPLTLPPTFPLPSGVYEPLMWEEVEARARLVHLEDVTRRQCHSAEVSGYLRAQRLTRCKTSFHFSDFSAKKRIHEAEVKLLREDMEVRAKRERAEHEEFMRAMTRGRTQLLKLPTITTSGKKYKPTEVDKHVARVLTFRKRAANKSDSKERHFLEIL
Protein: Ubiquitin-conjugating enzyme E2 13 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 13) (Ubiquitin carrier protein 13) (Ubiquitin-protein ligase 13) (Q42541)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.
Interaction partners:
- Ubiquitin-activating enzyme E1 1
- Ubiquitin-activating enzyme E1 2
- Ubiquitin-ribosomal protein eL40y fusion protein
- Ubiquitin-ribosomal protein eL40z fusion protein
- DNA repair protein RAD5A
- RING-box protein 1a
- Ubiquitin-conjugating enzyme E2 7
- Ubiquitin-conjugating enzyme E2 variant 1D
- E3 ubiquitin-protein ligase UPL4
- Ubiquitin-conjugating enzyme E2 14
Sequence:
MNSQACLLLQKQLKDLCKHPVDGFSAGLVDEKNIFEWSVTIIGPPDTLYEGGFFYAIMSFPQNYPNSPPTVRFTSDIWHPNVYPDGRVCISILHPPGDDPSGYELASERWTPVHTVESIMLSIISMLSGPNDESPANVEAAKEWREKRDEFKKKVSRCVRKSQEMF
Protein: Xrp1, isoform A (Xrp1, isoform B) (Xrp1, isoform F) (Xrp1, isoform G) (Q9VE23)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO08928p1
- ATP-dependent DNA helicase 2 subunit 1
- RE59279p
Sequence:
MIQEPARVQAAPTFEATIREDNAKYQETAAGGTYSSPNCSCSQRRTRPTEPTKDSPTSTITTIPIVIDSKPNPRILLIRVPTSNRGSNSNNNSNSTRSGTEHRAPRTRIIRIPFLPGSVPTRPPSNQAAPATSSLVNPIGSARRCRISTYPTTGTLTSRSQPETVAGLPTTAMVNQTVPVLSSAPQTQTLAAMAGIQLTGADEPPSRRDVSGAMPTATVEEIDVPVFIDEYLQDIEATSSTCNSENGKEIFTETDILDFDINMFAEEDLIELEGKKTDPFSPAMDGMNNDNLDDDFLQLNDLLNEEETFDMSSMSGVGIDINQEQELDFINIFHNSQPTAMLTSSEDPYLATYSQATSTSSTTKFITEEPLLADMTSFDISYTSSQELGFGLVEDVSGSFASSCSDVAAAIPAPIQHPIITNIKRSAPAPVESQPTKRSRLMLQIKTELAPAFSPTTPEIINQLLNDDRFEAPTTSTSTSTSNTSISSSTHADIVEDLRSAEEETTTDFSAPNTPHSNYSASSSCAAPTCQTGYGGFLTAPTSPAYSTASTSVFSPSPASGISGKRKRGRPAKDHADGPDPVLMSSMKSEEERKAYQDRLKNNEASRVSRRKTKVREEEEKRAEDTLLAENLRLRARADEVASRERKFKKYLMERQRQKSTYVKQEQD
Protein: Sodium/potassium-transporting ATPase subunit alpha (Q9DGL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
Sequence:
MGRGEGREQYELAATSEQGGKKSKSKGKKEKDKDMDELKKEVDLDDHKLSLDELTRKYNTDLTRGLSGTRAKEILARDGPNALTPPPTTPEWVKFCKQLFGGFSTLLWIGAILCFLAYGILAASEEEPANDNLYLGIVLSAVVMITGCFSYYQEAKSSKIMDSFKNLVPQQALVIRDGEKKNINAEEVAVGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRTPDFSNDNPLETRNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGRTPISIEIEHFIHIITGVAVFLGVSFFILSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTSFDRSSATWAALARVAGLCNRAVFLAEQENIPILKRDVAGDASESALLKCIELCCGSVKEMREKYNKISEIPFNSTNKYQLSIHQNPNSNNTESKHLLVMKGAPERILDRCSSILIQGKEQPLDDEMKDAFQNAYLELGGLGERVLGFCHFNLPDEQFPEDFQFDTEEVNFPTENLCFIGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPINEVNPRDAKACVIHGGDLKDLSPEQLDDVLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPKTDKLVNERLISIAYGQIGMIQALAGFFTYFVILAENGFLPSSLLGIRVFWDDKYVNDLEDSYGQQWTYEQRKIVEFTCHTAFFTSIVIVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPNWWFCAFPYSLLIFIYDEIRKLIIRRSPGGWVERETYY
Protein: INO80 complex subunit C (IES6 homolog) (hIes6) (Q6PI98)
Organism: Homo sapiens (Human)
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:18922472}.
Interaction partners:
- Actin-related protein 5
- RuvB-like 2
- RuvB-like 1
- INO80 complex subunit B
- Actin-related protein 8
- Chromatin-remodeling ATPase INO80
- INO80 complex subunit E
- Transcriptional repressor protein YY1
- Actin-like protein 6A
- Microspherule protein 1
Sequence:
MAAQIPIVATTSTPGIVRNSKKRPASPSHNGSSGGGYGASKKKKASASSFAQGISMEAMSENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTIEEFSYIRRLPSDVVTGYLALRKATSIVP
Protein: Aspartate carbamoyltransferase catalytic subunit (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) (Q727F4)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Dihydroorotase
- Carbamoyl phosphate synthase large chain
- Bifunctional protein PyrR
- Carbamoyl phosphate synthase small chain
- Uracil permease
- Orotidine 5'-phosphate decarboxylase
- Adenylosuccinate synthetase
- Orotate phosphoribosyltransferase
- Dihydroorotate dehydrogenase
- asparagine synthase
Sequence:
MQNETRSLWPHKDLLDVDQLSKDELLHLLDTAAQFHEINRRPVKKVPTLKGKSVILFFAEPSTRTKTSFDVAGKRLSADTFSLAKSGSSLQKGESLKDTALTLEAMNPDVLVIRHSSSGAARFLAERLACGVVNAGDGWHAHPTQALLDCYSLRQVWGDTFEGRTLCILGDIAHSRVARSNVKLLTSLGVRVRLCAPRTLLPAGVGNWPVEVFTDLDAAVRDADAVMCLRLQLERQQAGLLPDLREYSNRYCLTPRRLELAKPEAKVLHPGPMNRGLEIASSIADAPASLVLDQVAAGVATRMAILFLLATRTDGGR
Protein: Gibberellin 3-beta-dioxygenase 1 (EC 1.14.11.15) (GA 3-oxidase 1) (AtGA3ox1) (Gibberellin 3 beta-hydroxylase 1) (Q39103)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts the inactive gibberellin (GA) precursors GA9 and GA20 into the bioactives gibberellins GA4 and GA1, respectively. Involved in the production of bioactive GA for vegetative growth and development.
Interaction partners:
- Gibberellin 20 oxidase 1
- Gibberellin 20 oxidase 3
- Gibberellin 20 oxidase 4
- Gibberellin 20 oxidase 2
- Ent-kaur-16-ene synthase, chloroplastic
- DELLA protein RGA
- DELLA protein GAI
- Gibberellin receptor GID1B
- Ent-copalyl diphosphate synthase, chloroplastic
- Ent-kaurene oxidase, chloroplastic
Sequence:
MPAMLTDVFRGHPIHLPHSHIPDFTSLRELPDSYKWTPKDDLLFSAAPSPPATGENIPLIDLDHPDATNQIGHACRTWGAFQISNHGVPLGLLQDIEFLTGSLFGLPVQRKLKSARSETGVSGYGVARIASFFNKQMWSEGFTITGSPLNDFRKLWPQHHLNYCDIVEEYEEHMKKLASKLMWLALNSLGVSEEDIEWASLSSDLNWAQAALQLNHYPVCPEPDRAMGLAAHTDSTLLTILYQNNTAGLQVFRDDLGWVTVPPFPGSLVVNVGDLFHILSNGLFKSVLHRARVNQTRARLSVAFLWGPQSDIKISPVPKLVSPVESPLYQSVTWKEYLRTKATHFNKALSMIRNHREE
Protein: Leucine-rich repeat receptor-like protein FASCIATED EAR2 (CLAVATA2-like protein) (Q940E8)
Organism: Zea mays (Maize)
Function: Receptor-like protein that regulates shoot meristem proliferation. Based on additive and synergistic phenotypes of double mutants, it is probable that unlike CLV1 and CLV2 in A.thaliana, FAE2 and TD1 do not function exclusively in a single pathway.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Guanine nucleotide-binding protein alpha subunit
- Receptor-like protein kinase 5
- Squamosa promoter-binding-like protein 15
- Homeotic protein knotted-1
- Ramosa 1
- non-specific serine/threonine protein kinase
- LOB transcription factor
- Transcription factor bHLH83
- AGG2
- Fon2-like cle protein1
Sequence:
MLTATPLPHQLLATFLLVLASATQPAVPASTDRAALLAFRASLSPPSRAALSSWSGPLSPSWLGVSLHPATAPAPSVTTPSVAELSLRGLNLTGVIPAAPLALLRRLRTLDLSANALSGELPCSLPRSLLALDLSRNALSGAVPTCLPSSLPALRTLNLSANFLRLPLSPRLSFPARLAALDLSRNAISGAVPPRIVADPDNSALLLLDLSHNRFSGEIPAGIAAVRSLQGLFLADNQLSGDIPPGIGNLTYLQVLDLSNNRLSGSVPAGLAGCFQLLYLQLGGNQLSGALRPELDALASLKVLDLSNNKISGEIPLPLAGCRSLEVVDLSGNEISGELSSAVAKWLSLKFLSLAGNQLSGHLPDWMFSFPLLQWLDLSSNKFVGFIPDGGFNVSEVLNGGGGQGTPSESVLPPQLFVSASVDTVSWQLDLGYDVQATTGIDLSGNELCGEIPEGLVDMKGLEYLNLSCNYLAGQIPAGLGGMGRLHTLDFSHNGLSGEVPPGIAAMTVLEVLNLSYNSLSGPLPTTKFPGALAGNPGICSGKGCSENARTPEGKMEGSNHRGWLGGWHGENGWVSLGAFCISTMTSFYVSLATLLCSSNARNFVFRPVRVEY
Protein: Uncharacterized transcriptional regulatory protein C965.10 (O59830)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized transcriptional regulatory protein C1773.12
- AP-1 complex subunit gamma-1
- AP-1 complex subunit sigma-1
- AP-1 complex subunit beta-1
- AP-2 complex subunit beta
- ADP-ribosylation factor 1
- AP-2 complex subunit alpha
- Uncharacterized protein C328.01c
- Exportin-1
Sequence:
MTSTSHFVASTVKKPRSRYGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWKQPGTERKNKTKWRKAMQNNSIPIQDLADDFELDFPDTLDLTNPDALPVLGESIVNPISLPVDVASPFLPSECYPSKVELPYFPLLSKPNTLLSLLNDEEISCCEYYCYSVAPITTILPGQPNFLPQLLLPMALHEESVLYSLVASGYRLKYGNDNSLALQKSKVFVNRALLTLPERRSLNLSKSEFVVSLACYILLVYTEIAFADTTEWATYFLNAYNMINKMGGFKILKECSSEGKLLAECFAYFDILASQSNLNGTYYSISDYTDVYGVDELQLFESLENCIKPLVLIIGDIINLLVESRRAGFDDLQHTLNIYEKSQTIEGKIWSCVPQYEDMKSNKLDSEKSEPLQLFKLYKTTTEMYLRQVISRMPPVSLEMQVLLHKQTQLIDLLLESSLRNSLSFPMLIAGLNAATDLQRTNFKNRVNCLCQNYTIGSLKKVWIVVQEIWKMNQNGNICIDWYEVVQKFGWRLNTGV
Protein: Protocadherin (Q6KEQ5)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MDLLSGTYIFAVLLACVVFQSGAQEKNYTVREEMPENVLIGDLLKDLNLSLIPDKSLTTPMQFKLVYKTGDVPLIRIEEGTGEIFTTGARIDREKLCAGIVLDARCFYEVEVAVLPDEIFRLVKIRFLIEDINDNAPLFPTTVINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADTNDNHPIFIEKEIEVSIPENAPIGSSVTQLHATDADIGENARIHFYFSNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTPARATVLVNVTDINDNVPSIDIRYIVNPTNGTVLLSENAPLNTKIALITVMDKDSEHNGRVTCFTDHEVPFRLRPVFSNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDENDNAPVFTQSFISLSVPENNSPGAQLTKISATDADSGQNAEISYMLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPPLMSNATVFVTVLDQNDNSPIFTHNEYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVSRSSTARVTINVVDVNDNKPIFIDPPSNYSFEWVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPDSLFNVVNVNFFINESVPNATLIYELVRRSIDAPANQNTETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVRCRQPPHLKASQKNKQNSEWVTPNPENRQMIMMKKKKKKKKKHPPKNLLLNFVTIEEAKPDDGENERNSVTLDLPIELEEQTMGKYNWGTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNSKHHIIQELPLDNTFVGCDSISKCSSSSSDPYSVSECSYPVTTFKAPVSVHIRPTMKEVVRSHTPMKEATTVEIWTHPHPHPQRRSDGKKAGKSQRRVTFHLPEGSQESISDGGLGDHDAGSLPSTSHALPLGYPQEEYFDHAAPNNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEASDTCTQECLILGHSDSCWMPATLTNPSPSQIKTSAICHS
Protein: Zinc finger protein 35 (Zinc finger protein HF.10) (P13682)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MTAELREAMALAPWGPVKVKKEEEEEENFPGQASSQQVHSENIKVWAPVQGLQTGLDGSEEEEKGQNISWDMAVVLKATQEAPAASTLGSYSLPGTLAKSEILETHGTMNFLGAETKNLQLLVPKTEICEEAEKPLIISERIQKADPQGPELGEACEKGNMLKRQRIKREKKDFRQVIVNDCHLPESFKEEENQKCKKSGGKYSLNSGAVKNPKTQLGQKPFTCSVCGKGFSQSANLVVHQRIHTGEKPFECHECGKAFIQSANLVVHQRIHTGQKPYVCSKCGKAFTQSSNLTVHQKIHSLEKTFKCNECEKAFSYSSQLARHQKVHITEKCYECNECGKTFTRSSNLIVHQRIHTGEKPFACNDCGKAFTQSANLIVHQRSHTGEKPYECKECGKAFSCFSHLIVHQRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLPYVCNECGKAFTCSSYLLIHQRIHNGEKPYTCNECGKAFRQRSSLTVHQRTHTGEKPYECEKCGAAFISNSHLMRHHRTHLVE
Protein: Bcl-2 family member protein (Q7KM33)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGQRNKGLSSNNSGQPSIALPSTSTMAPTTSPPPKLAKFKSSSLDHEIYTANRRGTIATASSDWKALRGGVGGGAGGPGSVPNPSNGRSLHAGGPMTRAASTSSLASSTRTMTNYQEYKMDIINQGKCLCGQYIRARLRRAGVLNRKVTQRLRNILDPGSSHVVYEVFPALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVAKDLFRSSITWGKIISIFAVCGGFAVDCVRQGHFDYLQCLIDGLAEIIEDDLVYWLIDNGGWLGLSRHIRPRVGEFTFLGWLTLFVTISAGAYMVSNVCRRIGGQLYSLLF
Protein: Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8) (Q96G25)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 22
Sequence:
MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR
Protein: Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) (Q9UBV8)
Organism: Homo sapiens (Human)
Function: Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6. Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11278427}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q641Z8}. Membrane {ECO:0000269|PubMed:11278427}; Peripheral membrane protein {ECO:0000269|PubMed:11278427}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:27716508}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the presence of Ca(2+) (PubMed:11278427). Localizes to endoplasmic reticulum exit site (ERES) (By similarity). {ECO:0000250|UniProtKB:Q641Z8, ECO:0000269|PubMed:11278427}.
Interaction partners:
- Kelch-like protein 12
- Programmed cell death protein 6
- Protein transport protein Sec31A
- Protein SEC13 homolog
- Cullin-3
- Protein transport protein Sec23A
- Protein transport protein Sec24C
- Protein transport protein Sec24A
- Protein transport protein Sec24B
- Protein transport protein Sec24D
Sequence:
MASYPYRQGCPGAAGQAPGAPPGSYYPGPPNSGGQYGSGLPPGGGYGGPAPGGPYGPPAGGGPYGHPNPGMFPSGTPGGPYGGAAPGGPYGQPPPSSYGAQQPGLYGQGGAPPNVDPEAYSWFQSVDSDHSGYISMKELKQALVNCNWSSFNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQALSQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMTASRML
Protein: Phosphoethanolamine transferase EptA (EC 2.7.-.-) (Lipid A 1-phosphoethanolamine transferase) (O24867)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Probably catalyzes the addition of a phosphoethanolamine moiety to the dephosphorylated 1-position of the disaccharide backbone of lipid A. Lipid A that is 1-phosphorylated is not a substrate for this enzyme.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:P36555}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P36555}.
Interaction partners:
- Lipid A 1-phosphatase
- Lipid A deacylase LpxR family protein
- Sialidase domain-containing protein
- 3-deoxy-d-manno-octulosonic acid hydrolase subunit 1
Sequence:
MASLFHLRFLKPLSCLQAGLLYSLIFGVLYHFPLFVYVYKESNQVSFIAMMVVVLFCVNGALFLALGLISASLMRWSAIVFSLLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYVIYKIPLKNSSKKAPFLAILALVFIFIASALANTKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFAPTIKPLPLFSPNHSHSFVVLVIGESARKHNYALYGYQKPTTPRLSKRLADNELTLFNATSCATYTTASLECILDSSFKNNAYENLPTYLTKAGIKVFWYSANDGEKNVKVTSYLKNYELIQKCPNCEAIAPYDESLLYNLPDLLKEHSNENVLLILHLAGSHGPNYDNKVPLNFRVFKPYCSSADLSSCSKESLINAYDNTIFYNDYLLDKIISMLENAKQPALMIYLSDHGESLGEEAFYLHGIPKSIAPKEQYEIPFIVYANEPFKEKHSIIQTQTPINQNVIFHSVLGVFLDFKNPSVVYRPSLDLLKHKKE
Protein: CXXC finger protein 5 (E7EVI8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAAAPASVADDTPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESADKATAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAV
Protein: Putative pentatricopeptide repeat-containing protein At1g19290 (Q9LN69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
Sequence:
MLRRSPARVVAYQLLPFLYTRSFSEASRTLRRELRGGNGRIRPELLERVSRLLVLGRYEALHDLSLDFSDELLNSILRRLRLNPEACLEIFNLASKQQKFRPDYKAYCKMVHILSRARNYQQTKSYLCELVALNHSGFVVWGELVRVFKEFSFSPTVFDMILKVYAEKGLVKNALHVFDNMGNYGRIPSLLSCNSLLSNLVRKGENFVALHVYDQMISFEVSPDVFTCSIVVNAYCRSGNVDKAMVFAKETESSLGLELNVVTYNSLINGYAMIGDVEGMTRVLRLMSERGVSRNVVTYTSLIKGYCKKGLMEEAEHVFELLKEKKLVADQHMYGVLMDGYCRTGQIRDAVRVHDNMIEIGVRTNTTICNSLINGYCKSGQLVEAEQIFSRMNDWSLKPDHHTYNTLVDGYCRAGYVDEALKLCDQMCQKEVVPTVMTYNILLKGYSRIGAFHDVLSLWKMMLKRGVNADEISCSTLLEALFKLGDFNEAMKLWENVLARGLLTDTITLNVMISGLCKMEKVNEAKEILDNVNIFRCKPAVQTYQALSHGYYKVGNLKEAFAVKEYMERKGIFPTIEMYNTLISGAFKYRHLNKVADLVIELRARGLTPTVATYGALITGWCNIGMIDKAYATCFEMIEKGITLNVNICSKIANSLFRLDKIDEACLLLQKIVDFDLLLPGYQSLKEFLEASATTCLKTQKIAESVENSTPKKLLVPNNIVYNVAIAGLCKAGKLEDARKLFSDLLSSDRFIPDEYTYTILIHGCAIAGDINKAFTLRDEMALKGIIPNIVTYNALIKGLCKLGNVDRAQRLLHKLPQKGITPNAITYNTLIDGLVKSGNVAEAMRLKEKMIEKGLVRGSDKQGDVDIPKEVVLDPEVKLGSTGVIEMNSNELYDVRRVSEAVV
Protein: Octopressin receptor (Q5W9T5)
Organism: Octopus vulgaris (Common octopus)
Function: Acts as a receptor for octopressin.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MENFTEENLHPWITTTTRVYNNVTIFPQYDDELGKFEIMVLCILCFMALFGNAVVLIVLRIKKTTLTRMQLLIVYLSVTDISVALFHILPTIILKINVYFLGDISACRVYQFITVAELYASSFVLIVTALDRYISICHPLAAHMWTNRRVHMTTALALFLALMCSLPQLDAVLVDFHGGKLCRPNLTTELANIAYSWWAFCSVFFVPLLLLIFFYGRICFVVWQSMRGRECTQSVGSSASRYVRKPIKCRISSQTSSENRVKNYSDARDKDSSRNPRAICRGVSKSKIKTIKLTFSVVACFIICYTPFFTVLMARTYDAELSSAQTPALVILSLLPSLNSCTNPWIYLAFSGKVWCRQQSQNFPRTWTQTTNTYLVELEAKKRTSFGAEHVTFASNSTARKTLNVDDTNTTALMSSSPC
Protein: Uncharacterized oxidoreductase C26F1.07 (EC 1.-.-.-) (Q10494)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Alcohol dehydrogenase 4
- Glycerol dehydrogenase 1
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Putative aldehyde dehydrogenase-like protein C922.07c
- Putative S-
- Probable S-
- Alcohol dehydrogenase
- Putative pyruvate decarboxylase C3G9.11c
- Putative monoglyceride lipase
- Putative pyruvate decarboxylase C13A11.06
Sequence:
MSAEQKYFENAQNVHFTLADGSKIPGLGLGTWRSEPNQTKNAVKTALQYGYRHIDAAAIYGNEDEVGDGIKESGVPRKDIWVTSKLWCNAHAPEAVPKALEKTLKDLKLDYLDEYLIHWPVSFKTGEDKFPKDKDGNLIYEKNPIEETWKAMEKLLETGKVRHIGLSNFNDTNLERILKVAKVKPAVHQMELHPFLPQTEFVEKHKKLGIHVTAYSPFGNQNTIYESKIPKLIEHETIQKIAKSKGEGVTGATIAVSWAITRGTSVIPKSVNEQRIKSNFKYIPLTKEDMDEINSIGIRARFNQATFSNEPVFAGLEDGRT