wanglab/gogpt-training-data huggingface dataset:
Protein: dextransucrase (EC 2.4.1.5) (Dextransucrase) (Sucrose 6-glucosyltransferase) (D5FS20)
Organism: Leuconostoc citreum
Interaction partners:
Sequence:
MEQQETVTRKKLYKSGKSWVAAATAFAVMGVSAVTTVSDTHKTPVGTTQSQQALTGQTGQDKPTTKEVIDKKEPVPESTTNNDSKSVHASGKNIDQQNELNKNTATENNKKTQDQNTATTPDTKESNKAVSDDQKITVQDDRNIALSKNLVDNKDAISTVITGGRYEQQDGHFVYLDQSGKKVIGLQNINGNVQYFDENGAQVKGDFRPGKEKNKVYFDKNTGNAIAYISNVHGVINGVDATGKQIKDNFLTDEKGNTYYFDSQGNMLKGLQTLDGKQYYFDEEGLLKKNYAATFNNQVIYFDSVTGIGKTALEYQFSQGLTDQKSDFTAHNAANSYDAKSFDNIQGFLTADSWYQPKDILKGGKTWVASTEDDKRPLLMTWWPDKQTQANYINYMSKTFATNDGIQYDATTNQSTLNLATQNIQVLIEQRIAQANSIQWLKNEMSNFIKEQFNWSKKSENIDYGGLQFQGGFLKYNNTPLASDTNSAFRLLNRVLFNRDGNSNVKGSEFLLANDVDNSNPVVQAEQLNWLHYLMNFGTITANDPDANFDSIRVDAVDNVDADLLDIARDYFNAVYKVNQSDVNANKHISILEDWSGLDPNEVVKNGNPQLTLNTGVQNSLLNALTKGPNNRWGIDSLIDKSTMRYPDKDGKILIPNYSFVRAHDSEVQGIIGKILTDHTSAESGNKFTKDQLKQALDYYYADQDKTVKEYSHYNMASAYAALLTNKNTIPRVYYGDMYKDNDSYMTSKTNEFDSIDALLKARIKYVSGNQEMGVDTKHQDVLTSVRNGNSRTEGIGVIISNNPNLNLGSDKITLSMGVNHANQMYRPLLLATDNGIDVYITDSSTTIRETTDGNGNLEFSSNYIKGYGINNSKVSGYLAVWVPVGADDKQDARVATSQNKTTDGSVFHANDALDTNVIYEGFSNFQQTPNLVDKDQRTNVIIAKEAKNGTFSNWGITSFQMPPQYRSSHDGTFVDSTIDNGYAFTDRYDLGFNNDDGTENPTKYGTVEDLRNAIKALHSKSIQAMADWVPDQIYNLSGQQVTSVTRVNEKGETWPNADIENVLYVVDTVGGGKYQAEYGGKYLGELQQKYPDLFTKPQITTGVPMDANTRIKEWSAKYFNGTNILGRGAYYVLKDWASNQYFNVNKADEAFLPLQLMNQDAKTGFVIDAVGVKYYSISGYQAKNSFIQDDNHNWYYFDNNGYMVRPENGKSGLVQMKVTNADGTVRESLDSSNKDGRYYYFMPNGMEIRNGFVKDIDGKSYYFNSVGEMLTNQYVFDASGNAYHLNSDGTMSTGLVLAGYNNVYHYYGLNGVQVKGKVAYDKNTNKWYSFDANSGDSQAFTDRPNNTQDFITIDTSSTLGVNADYTAYITSSVRQDGLFANAPYGVITKDQTGNDIKWEFINKDTKQYEGQQVQVTRQYTDSKGVSWNLITFAGGDLQGQKLWVDSRALTMTPFKTMNQISFISYANRNDGLFLNAPYQVKGYQLAGMSNQYKGQQVTIAGVANVSGKDWSLISFNGTQYGLIVSH
Protein: Seco-amyrin synthase (EC 5.4.99.52) (EC 5.4.99.54) (Alpha-seco-amyrin synthase) (Beta-seco-amyrin synthase) (Pentacyclic triterpene synthase 6) (AtPEN6) (Q9SYN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Multifunctional enzyme that converts oxidosqualene to lupeol, bauerenol, alpha-amyrin, taraxasterol, psi-taraxasterol, multiflorenol, alpha-seco-amyrin and beta-seco-amyrin.
Interaction partners:
- Squalene epoxidase 2, mitochondrial
- Squalene epoxidase 3
- Squalene epoxidase 1
- Squalene epoxidase 5
- Squalene epoxidase 4
- Squalene epoxidase 6
- Lupeol synthase 1
- Camelliol C synthase
- Amyrin synthase LUP2
- Beta-amyrin synthase
Sequence:
MWRLKIGAKGGDETHLFTTNNYTGRQTWEFDADACSPEELAEVDEARQNFSINRSRFKISADLLWRMQFLREKKFEQKIPRVEIGDAENITYKDAKTALRRGILYFKALQAEDGHWPAENSGCLFFEAPFVICLYITGHLEKILTLEHRKELLRYMYNHQNEDGGWGIHVEGQSAMFCTVINYICLRILGVEADLDDIKGSGCARARKWILDHGGATYTPLIGKAWLSILGVYDWSGCKPIPPEVWMLPTFSPFNGGTLWIYFRDIFMGVSYLYGKKFVATPTPLILQLREELYPQPYDKILWSQARNQCAKEDLYYPQSFLQEMFWKCVHILSENILNRWPCNKLIRQKALRTTMELLHYQDEASRYFTGGCVPKPFHMLACWVEDPDGDYFKKHLARVPDYIWIGEDGLKIQSFGSQLWDTAFSLQVMLAYQDVDDDDDEIRSTLIKGYSFLNKSQLTQNPPGDHRKMLKDIAKGGWTFSDQDQGWPVSDCTAESLECCLVFGSMPSELIGEKMDVERLYDAVNLLLYFQSKNGGITVWEAARGRTWLEWLSPVEFMEDTIVEHEYVECTGSAIVALARFLKEFPEHRREEVEKFIKNAVKYIESFQMPDGSWYGNWGVCFMYGTFFAVRGLVAAGKTYQNCEPIRKAVQFILETQNVEGGWGESYLSCPNKKYTLLEGNRTNVVNTGQALMVLIMGGQMERDPLPVHRAAKVLINSQLDNGDFPQEEIMGVFKMNVMVHYATYRNIFTLWALTYYTKALRVPLC
Protein: ATR interacting protein (A0A0U1RRM7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIK
Protein: Mitochondrial import receptor subunit TOM20-4 (Translocase of outer membrane 20 kDa subunit 4) (P82805)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.
Subcellular location: Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial import receptor subunit TOM9-1
- Mitochondrial import receptor subunit TOM20-2
- Mitochondrial import receptor subunit TOM9-2
- Mitochondrial import receptor subunit TOM20-3
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Mitochondrial import inner membrane translocase subunit TIM44-1
- Mitochondrial import receptor subunit TOM6 homolog
- Mitochondrial import receptor subunit TOM5 homolog
- Mitochondrial import receptor subunit TOM40-1
- At1g05270
Sequence:
MDMQNENERLMVFEHARKVAEATYVKNPLDAENLTRWAGALLELSQFQTEPKQMILEAILKLGEALVIDPKKHDALWLIGNAHLSFGFLSSDQTEASDNFEKASQFFQLAVEEQPESELYRKSLTLASKAPELHTGGTAGPSSNSAKTMKQKKTSEFKYDVFGWVILASYVVAWISFANSQTPVSRQ
Protein: Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11) (Q6L8G4)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 5-7
Sequence:
MGCCGCSGGCGSGCGGCGSGSGGCGSGCGGCGSSCCVPICCCKPVCCCVPACSCSSCGSCGGSKGGCGSCGSSKGGCGSCGCSQSNCCKPCCSSSGCGSFCCQSSCSKPCCCQSSCCQSSCCKPCCCQSSCCQSSCFKPCCCQSSCCVPVCCQCKI
Protein: ribose-phosphate diphosphokinase (EC 2.7.6.1) (Q5BBW5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Amidophosphoribosyltransferase
- Phosphoglucomutase, putative
- Ribose-5-phosphate isomerase
- Ribose 5-phosphate isomerase
- Ribokinase
- Transketolase
- Phosphoglucomutase
- ATP phosphoribosyltransferase
- MutT/nudix family protein
- Ribose-phosphate pyrophosphokinase
Sequence:
MATNSIKLLTGNSHPELANLVADRLGIELTKIMVLQYSNQETSVTIGESVRDEDVFILQSTRPNDINDGLMELLIMINACKTASARRITAVIPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSMLKWIRENLDVSNCVIVSPDAGGAKRATAIADRLDLQFALIHKERPRPNEVSRMVLVGSVKDKVAIIVDDMADTCGTLVKAADTVMQHGAKEVNAIVVHGILSGKAIDNVNNSCLKRIVVTNTVPHKEKKELCDKIETIDISPTLAEACRRTHNGESVSFLFSHTVA
Protein: Plexin-B2 (MM1) (O15031)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Semaphorin-4D
- Semaphorin-4C
- Rho guanine nucleotide exchange factor 12
- Rho guanine nucleotide exchange factor 11
- Semaphorin-4A
- Semaphorin-4G
- Rho-related GTP-binding protein Rho6
- Ras-related protein R-Ras
- Semaphorin-4B
- Rho-related GTP-binding protein RhoD
Sequence:
MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSLILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL
Protein: Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (P32288)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- NADP-specific glutamate dehydrogenase 2
- NADP-specific glutamate dehydrogenase 1
- Glutamate synthase
- NAD-specific glutamate dehydrogenase
- Amidophosphoribosyltransferase
- Carbamoyl phosphate synthase arginine-specific small chain
- Carbamoyl phosphate synthase arginine-specific large chain
- Multifunctional protein URA2
- Urea amidolyase
- Glutamine--fructose-6-phosphate aminotransferase
Sequence:
MAEASIEKTQILQKYLELDQRGRIIAEYVWIDGTGNLRSKGRTLKKRITSIDQLPEWNFDGSSTNQAPGHDSDIYLKPVAYYPDPFRRGDNIVVLAACYNNDGTPNKFNHRHEAAKLFAAHKDEEIWFGLEQEYTLFDMYDDVYGWPKGGYPAPQGPYYCGVGAGKVYARDMIEAHYRACLYAGLEISGINAEVMPSQWEFQVGPCTGIDMGDQLWMARYFLHRVAEEFGIKISFHPKPLKGDWNGAGCHTNVSTKEMRQPGGMKYIEQAIEKLSKRHAEHIKLYGSDNDMRLTGRHETASMTAFSSGVANRGSSIRIPRSVAKEGYGYFEDRRPASNIDPYLVTGIMCETVCGAIDNADMTKEFERESS
Protein: Traffic jam, isoform C (M9PG80)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription factor kayak, isoforms A/B/F
Sequence:
MKMEDPTINDTYVQEFDLHHLEVGGNGAGQSHGAGAASQVTTLGHVKREDHSPPQPVAVKWTTIHGDPTNPDDDPDSLPLSGPEPAGAVEVSPSPHIKLRSFSGHHQWHMDERRLQPLSPPPEQYGPLPGQAILVNTSSGAGVPGGVPSTPPETPPVVGSPTGSSSCPAQTYAHHYARTPGSSVSVSASAAAAAAASAGAASVSAGLSHDMMWLTNSIRADQQPLDLRPLPYPGSQEEAEEWDRQRDYALQAAAAHHHHHGQPLMQAQHHPHGHGGHPHQVMLQQSKYPHHHHHHFHNLELTPINMHSNSYGSASGALTPTCLPQVPSNGSGSSGGGGGSGSGSGGPGSVGGGSCVITRAALQPCRPLSASSTRSSNNMSPRTCSGAYSNATLEDCLNDDMLTTLTVRELNKRLHGCPREEVVRLKQKRRTLKNRGYAQNCRSKRLHQRHELEKANRVLNQDLHRLKLEYSRVCQERDALMQRLQRAANGGVGAGGATAGGDSQSSPEFYLXRQLAVASGSSASSSSSSQQQQQHPQQLHLQHRGPQWNPQQLVN
Protein: Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) (Q29400)
Organism: Ovis aries (Sheep)
Function: Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P18065}.
Interaction partners:
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Cation-independent mannose-6-phosphate receptor
Sequence:
MQPRLGGPALLLLPPLLLLLLLGAGGGDCGARAEVLFRCPPCTPESLAACKPPPGAAAGPAGDARVPCELVREPGCGCCSVCARLEGERCGVYTPRCGQGLRCYPNPGSELPLRALVHGEGTCEKHGDAEYSASPEQVADNGEEHSEGGQVENHVDGNVNLMGGGGGAGRKPLKFRMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQGARGVHTQRMQ
Protein: Phytochromobilin:ferredoxin oxidoreductase, chloroplastic (EC 1.3.7.4) (PFB synthase) (PPhiB synthase) (Phytochromobilin synthase) (Q9SR43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the two-electron reduction of biliverdin IX-alpha to the tetrapyrrole chromophore phytochromobilin (PPhiB).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11226195}.
Interaction partners:
- Heme oxygenase 1, chloroplastic
- Heme oxygenase 3, chloroplastic
- Heme oxygenase 4, chloroplastic
- Tetrapyrrole-binding protein, chloroplastic
- Phytochrome B
- Magnesium-chelatase subunit ChlH, chloroplastic
- Phytochrome A
- Ferrochelatase-1, chloroplastic/mitochondrial
- Pentatricopeptide repeat-containing protein GUN1, chloroplastic
- Glutamyl-tRNA reductase 2, chloroplastic
Sequence:
MALSMEFGFSIGSCFKAPNPPVLISASPNKINFTLRRRKKRFLLRVSAVSYKEFAESALEETRKRIVLEPSHLQEKYSSMTGLDGKTELQMLAFKSSKIRLLRSMAIENETMQVFDFAGFMEPEYDTPIFCANFFTSTNVNIVVLDLNPLHQLTDQTDYQDKYYNKIMSIYHKYAETFPWGGKLTGESIKFFSPLVMWTRFSSSKEKHKALFSAFLEYYQAWLEMTIQVREEMEPSHVRANCEAQHKYLTWRAQKDPGHGLLKRLVGEAKAKELLRDFLFNGVDELGTKTFIDYFPEYQTEDGTVSDKRSIIGKSYETRPWDLTGQFIG
Protein: Tensin 1 (E9PGF5)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}.
Interaction partners:
Sequence:
MSVSRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEEVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTLSSLDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSAQEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNSWQQQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSGHSLGTPEPAPRASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGPQQPPASLPGLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNKVATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQKR
Protein: Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Disruptor of telomeric silencing A) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (SAM domain-containing protein) (Q55AX2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing, correct growth and development, and for resistance to DNA damage induced by UV LIGHT.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q04089}.
Interaction partners:
- Histone-lysine N-methyltransferase set1
- Histone H4
- Probable E3 ubiquitin-protein ligase bre1
- Histone H3.3 type c
- Histone H3.3 type a
- Histone H3.3 type b
- Histone H2B.v3
- Ubiquitin-conjugating enzyme E2 2
- SET domain-containing protein
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MSTNSTPRKQKLSNSKSLQNSPISPTVKKTNSFPLGNNIPTNINRSKKDKNNNSNNNINNNNSNGIGSNTIINSTPIATTPVPPLPFIHSSSSSSSSPSPSSSSSSPFPKAKKSPSLSINQQQQQQPQQPQQSPQSQQSPQSQQSQQSQQQQPQQPQEQQEPLPNLSFLRNQEPDKNVLPTSRKRPPSVMPSTPNQSSNSSSLNSSLNFSSSNSSPSPTSTQSNNSRFETRSQNDQYENNNNNNNNNNNNNNNNNNNNNNNNNIECIVIDDDDDDDDDEGNSIKSTHTSTQSTPIRDRRQRDNKWTINPLPQFQREIIDVDTPSPPNESLSIVSQTTTNTITDTTSIQTPTLIRQSSSLLSSSSSLSPSTTSTPLTQNNINLQNAQVIATMTAPMEIELPTIVQLEPLFSSEFTTSTQNLFIQTPPFTSTLTLPTTTAQTSQTLFTIQTSHDINNNNNNNNNNKNKNKNKKEIEKEKEKLREALKQKLKEYENENEKEREKERKREREIEIERERKERERKEREKERKKEKEREREREERERKEIERKEREREEREERERKEIERKETERKEIERKEIERKEIERKERERKERKEREEREEREREERERKEREEREKEIEMEREKKKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKKRKENEVENEIEKERREKNDSYMVLNYHHSIDDHHSESESESDSDQDSIYSISTQELSSVISDNDFCDSDNEKVANNNRTVGETFLNDSRNNNNNNNNNKNNNNKKIENDKNQLIERERLISAFNDKAFLYALDTIREVLGGIDFKLKVSKEQIIEISTNAKKPLNILSEPEQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQTTKTTTTTNNTTTTTAETEKPKEVFLLKKPIKIPYGRDCKKRLIRRFHGTSRNPLFHKNLESTLKLLKRAKFDWASIEFDTKSYLMNCNCKTVCHKSERMKDNPTNKLQNNNRNNNNNNNNIINNNNNNNNKNNNNKNNNNKNNNRNNNSIAKKIGTNNNNNNTTIIKNNNNNNNNNNNNNNNNNNIIKNNNNNNKNNNNNNNTIVKKIETIKKDINKKPTKTTTTTSSSSSSTSSSNSLTVIKKPVKKINGSQRICLFEDDFDVGIGVPVTTGTSETTTTRASSIRRKMNISNIFDDFTKKPRQNKYNEIEMPDLFASKECNYTLEQQAPFIRAQKLLLTQQHENNLYNGKRFMKYDEWLDLYHGEMRSSIQNPKVLKHYISFSQEVYGEAEPTLLRHWIHLGLIKPTDVFCDIGCGIGNVLFQLAAQVGCRVIGVEIRKDLYDISQSMLEIYKKRSLELGLHPSTQQIKIYNCDVKGSLEFDFSEPNVFFMHNTCFGPELEISIMELFKKYSKPGTKVITMKTLCPRFKPSDKKTKPWGIFKYPYESYEMEEGSLSWRSATNCSFYSFTIDDKDSDIVTDQTHLNRVILSTPKKKHSKLQLFSSSSLPSSPPSSSSSSSPPNIATNTTTTTTTTTTTSPSSISLPSPYLSPSKKTPNSNKRDRSDIDNSNSDDGDENNNNININNNNNNSNNKPIKLKLSMDHSIDNQSNSESSDTDVEYMPWSKRNNRKKRKSLSYSLDSYLSSRISPSLSLSTSSSSSSSLDSSPYSSPPSSSSSDNENDDDNGDDEDDSSSSNDTKLKEKLLLMKNNEKIGGAPPLTRRNANSDTNKLVQGCYQSLSSYALPKEESQIHKLQLQAKLLEHKNSLVLKHQKSIHDQQKRLSRKQKKLAKKNKKKEQQLQAQAKTINYNNNNNNNNQNDNQVNHNNLNENEINTDLINGYNNNNNNNIINNDNDNDNDNDKDDDKDSNNKDYNNINDNNK
Protein: Myosin VI (A0A590UJ75)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERL
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LIN7)
Organism: Oryza sativa (Rice)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) (P33260)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11093772}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:11093772}; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 3A7
- Cytochrome P450 1A1
- Cytochrome P450 3A5
- Cytochrome P450 4A11
- Epoxide hydrolase 1
- Cytochrome P450 26A1
- Cytochrome P450 4A22
- Cytochrome P450 1A2
- Cytochrome P450 26B1
- Cytochrome P450 26C1
Sequence:
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
Protein: Muscleblind-like splicing regulator 1 (A0A0G2JX72)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- CUGBP Elav-like family member 1
- KH domain-containing RNA-binding protein QKI
- Chloride channel protein 1
- Serine/arginine-rich splicing factor 1
- CCHC-type zinc finger nucleic acid binding protein
- Myotonin-protein kinase
- Fragile X messenger ribonucleoprotein 1
- RNA binding protein fox-1 homolog 1
- ATP-dependent RNA helicase A
- RNA binding protein fox-1 homolog 2
Sequence:
MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVDTHNICRTSD
Protein: Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase) (mWee1B) (Q66JT0)
Organism: Mus musculus (Mouse)
Function: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Subcellular location: Cytoplasm. Nucleus. Note=Localizes mainly in the nucleus. Exported from the nucleus to the cytoplasm before germinal vesicle breakdown (GVBD), allowing meiosis resumption.
Interaction partners:
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase Chk1
- Wee1-like protein kinase
- M-phase inducer phosphatase 2
- Serine/threonine-protein kinase Chk2
- M-phase inducer phosphatase 1
- G2/mitotic-specific cyclin-B1
- Cytoskeleton-associated protein 5
Sequence:
MADTETDQGLNKKLSFSFCEEDTESEGQMTAQDIGGAQSQKPGREESEELEGPVPPTRDELHTSLSRDKESPGPDLWKSVSGPPKCPETPVLHSKSKLPVPTNFSTPKNSLGQPEISLLEKLSSRSSRHMRLTPASLMDEKTSLSLVNINPFTPETYRKLLLQSKGKRKTRDYLEETGEEESKSVQWLPAKRSILQETNMASRYEKEFFEIEKIGVGEFGTVYKCIKRLDGCIYAIKRSAKSFSGLSNELDLHEVYAHAVLGHHPHVVRYYSSWIEDDHVVIQNEYCNGGSLQAAISENTASNNHFQEPKLKDILLQISLGLKYIHNSGMVHLDIKPSNIFICHKMQCDSPVGPEEAESEADWFLNASVMYKIGDLGHATSISKPKVEEGDTRFLANEILQENYQHLPKADIFALGLTIAVAAGAESLPINGDMWHHIRKGNFPEISQELSDDFYGLLKNMIHPAPKERPSAAALARSRILWPFLEKTDELQKQLNLEKSKTATLKRELKKARHIQTPQREVHHCYYQICKGSRHLLVGGRRKAPSSFTRGTSSV