wanglab/gogpt-training-data huggingface dataset:
Protein: Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4) (O43246)
Organism: Homo sapiens (Human)
Function: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial
Sequence:
MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPEPGELKPALRPYLGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVFPRGSLEETVQAMQPPSQAPAQDPGHME
Protein: Deoxyhypusine synthase (EC 2.5.1.46) (Q6NYK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Deoxyhypusine hydroxylase
- Eukaryotic translation initiation factor 5A-1
- Eukaryotic translation initiation factor 5A
- ornithine decarboxylase
- Spermidine synthase
- S-adenosylmethionine decarboxylase proenzyme
- Spermine synthase.
- Delta-1-pyrroline-5-carboxylate synthase
- SPO11 initiator of meiotic double stranded breaks.
Sequence:
MAGQAPPVARAAVLKESTPLPDNLPQIRGYDFNQGLNHRALLQSFITTGFQASSFGLAVQEINKMIEKRLEPVQEECEDSDSRQSALGCTIFLGYTSNLISSGVRESIRYLTQHKMVDVIVTTAGGIEEDLIKCLAPTFLGEFSLKGKELRQQGINRIGNLLVPNENYCKFEDWLMPILDQMVLEQKTEGTHWTPSKMIHRLGKEINNPDSVYYWAYKNDIPVFSPALTDGSLGDMIYFHSYKNPGLVLDIVEDIRRLNSKAVFAKSTGMIILGGGLVKHHIANANLMRNGADFAVFVNTGQEFDGSDSGARPDEAISWGKIRMDASPVKVYADASLVFPLLVAETFAHNASRLIQEKKSD
Protein: Cytokinin hydroxylase (EC 1.14.13.-) (Cytochrome P450 35A1) (Q9FF18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cytokinin hydroxylase that catalyzes the biosynthesis of trans-zeatin via the isopentenyladenine riboside 5'-monophosphate (iPRMP)-dependent pathway. Can use isopentenyladenosine-5'-monophosphate, isopentenyladenosine-5'-diphosphate and isopentenyladenosine-5'-triphosphate as substrate.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Adenylate isopentenyltransferase 1, chloroplastic
- Adenylate isopentenyltransferase 4
- Adenylate isopentenyltransferase 5, chloroplastic
- Adenylate isopentenyltransferase 3, chloroplastic
- Adenylate isopentenyltransferase 8, chloroplastic
- Adenylate isopentenyltransferase 6, chloroplastic
- Adenylate isopentenyltransferase 7, mitochondrial
- Cytokinin hydroxylase
- Haloacid dehalogenase-like hydrolase
- Cytokinin dehydrogenase 7
Sequence:
MLLTILKSLLVIFVTTILRVLYDTISCYWLTPRRIKKIMEQQGVTGPKPRPLTGNILEISAMVSQSASKDCDSIHHDIVGRLLPHYVAWSKQYGKRFIVWNGTDPRLCLTETELIKELLMKHNGVSGRSWLQQQGTKNFIGRGLLMANGQDWHHQRHLAAPAFTGERLKGYARHMVECTSKLVERLRKEVGEGANEVEIGEEMHKLTADIISRTKFGSSFEKGKELFNHLTVLQRRCAQATRHLCFPGSRFLPSKYNREIKSLKKEVERLLIEIIQSRRDCAEMGRSSTHGDDLLGLLLNEMDIDKNNNNNNNNLQLIMDECKTFFFAGHETTALLLTWTTMLLADNPTWQEKVREEVREVFGRNGLPSVDQLSKLTSLSKVINESLRLYPPATLLPRMAFEDLKLGDLTIPKGLSIWIPVLAIHHSEELWGKDANQFNPERFGGRPFASGRHFIPFAAGPRNCIGQQFALMEAKIILATLISKFNFTISKNYRHAPIVVLTIKPKYGVQVILKPLVS
Protein: Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) (Q96NW7)
Organism: Homo sapiens (Human)
Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11729199}. Postsynaptic density {ECO:0000250}.
Interaction partners:
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Catenin delta-2
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Glutamate receptor ionotropic, NMDA 2B
- Disks large homolog 1
- Glutamate receptor 1
- Disks large homolog 4
- Plakophilin-4
- Connector enhancer of kinase suppressor of ras 2
Sequence:
MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
Protein: Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] (P00787)
Organism: Rattus norvegicus (Rat)
Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).
Subcellular location: Lysosome {ECO:0000269|PubMed:8001549}. Melanosome {ECO:0000250|UniProtKB:P07858}. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000250|UniProtKB:P10605}.
Interaction partners:
- Cathepsin D
- NACHT, LRR and PYD domains-containing protein 3
- Procathepsin L
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Caspase-1
- BH3-interacting domain death agonist
- Legumain
- Annexin A2
- Urokinase-type plasminogen activator
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
Protein: Transcription factor UPBEAT1 (Basic helix-loop-helix protein 151) (AtbHLH151) (bHLH 151) (Transcription factor EN 146) (Transcription factor bHLH151) (bHLH transcription factor bHLH151) (O22901)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that modulates the balance between cellular proliferation and differentiation in root growth. Does not act through cytokinin and auxin signaling, but by repressing peroxidase expression in the elongation zone.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:21074051}.
Interaction partners:
- Peroxidase 40
- Peroxidase 57
- Transcription factor bHLH148
- F-box protein SKP2B
- Transcription factor MYB36
- Respiratory burst oxidase homolog protein C
- Peroxidase 39
- Protein GOLVEN 11
Sequence:
MGVTLEGQRKESIWVLMRRQRARRALVKKIMIRPRKSVEASRRPCRAIHRRVKTLKELVPNTKTSEGLDGLFRQTADYILALEMKVKVMQTMVQVLTETNCV
Protein: Glutamate receptor ionotropic, NMDA 1 (GluN1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (A0A1L8F5J9)
Organism: Xenopus laevis (African clawed frog)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19524674, ECO:0000269|PubMed:21677647, ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:26912815, ECO:0000269|PubMed:27135925, ECO:0000269|PubMed:27916457, ECO:0000269|PubMed:28232581}; Multi-pass membrane protein {ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:27062927, ECO:0000269|PubMed:28232581}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P35438}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P35439}. Synaptic cell membrane {ECO:0000250|UniProtKB:P35438}. Note=Synaptic cell membrane targeting is dependent of GRIN2B/GluN2B subunit (By similarity). Association with GRIN3A occurs in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:P35439}.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 2B
- Uncharacterized protein.
- Glutamate receptor
- Uncharacterized protein.
- Peripheral plasma membrane protein CASK
- Peripheral plasma membrane protein CASK
- Uncharacterized protein.
- Uncharacterized protein.
- Uncharacterized protein.
- Glutamate receptor
Sequence:
MGTMRLFLLAVLFLFSFARAGCDPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFANYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCVDLLIKLAREMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNILKSHENGFMEELDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKDTVNVVV
Protein: DnaJ (Hsp40) homolog, subfamily B, member 6 (DnaJ homolog subfamily B member 6b) (Q7ZW83)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEEDYYHILGVTKSASPDDIKKAYRKLALKWHPDKNPNDKEEAEKRFKEISEAYEVLSDENKRRDYDRYGKQGLSNRGGHYDDEYMGGFTFRNPEDVFREFFGGHDPFADFFADDPFEGFFGGHRHRGMSRSRTAGPFFPGFSPFGPSFSGFDTGFSPFGPMGGGSFSSFSSSPFGGGGGMRNFTSISTSTKFINGKRITTKRIVENGQERVEVEEDGQLKSLTVNGKEQLLRLDSK
Protein: Glutathione peroxidase (Q9VZQ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSANGDYKNAASIYEFTVKDTHGNDVSLEKYKGKVVLVVNIASKCGLTKNNYEKLTDLKEKYGERGLVILNFPCNQFGSQMPEADGEAMVCHLRDSKADIGEVFAKVDVNGDNAAPLYKYLKAKQTGTLGSGIKWNFTKFLVNKEGVPINRYAPTTDPMDIAKDIEKLL
Protein: Saitohin (Q8IWL8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16186110}. Nucleus {ECO:0000269|PubMed:16186110}.
Interaction partners:
- KAT8 regulatory NSL complex subunit 1
- Corticotropin-releasing factor receptor 1
- Microtubule-associated protein tau
- Peroxiredoxin-6
- Histone H1.2
Sequence:
MSEGGGQVSCIFAAPTRLCRWPALIECGVNLTQPLCEWMIQVARDRTLSLAWEVASLLTLSSSEVGLEGVGTIWPSSYSSEESSRNGAEQGRQLSIEGPFQGQNCPSHPAAALPLPMRGESQATSCQV
Protein: Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2) (Q8K1B8)
Organism: Mus musculus (Mouse)
Function: Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
Subcellular location: Cell projection, podosome {ECO:0000269|PubMed:16876785}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
Interaction partners:
- Integrin beta-3
- Integrin alpha-IIb
- Talin-1
- Integrin beta-2
- Scaffold protein ILK
- Paxillin
- Filamin-binding LIM protein 1
- Talin-2
- Vinculin
- Gamma-parvin
Sequence:
MAGMKTASGDYIDSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEEVHDLTKVVLAGGVAPTLFRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQRLPRPSSLPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLTEEIDCTEEEMMVFAALQYHINKLTLSGDVGELASGDLGLDDLDAALNNLEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEAPGDPTQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYAQWMAACRLASKGRTMADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEGLNPYGLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF
Protein: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (P63094)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8227063}; Lipid-anchor {ECO:0000269|PubMed:8227063}.
Interaction partners:
Sequence:
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Protein: Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1) (P41251)
Organism: Mus musculus (Mouse)
Function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:9730978}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:9730978}; Multi-pass membrane protein {ECO:0000255}. Note=After onfection, vesicles migrate to the site of bacterial phagosomes. {ECO:0000269|PubMed:9730978}.
Interaction partners:
- Natural resistance-associated macrophage protein 2
- Ferroportin
- NADPH oxidase 2
Sequence:
MISDKSPPRLSRPSYGSISSLPGPAPQPAPCRETYLSEKIPIPSADQGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWDGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAHPSQGALLKGLVLPTCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRVDVREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLQNYAKIFPRDNNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDLKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVMQEFANGRMSKAITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALFAIGYLGLTAYLAWTCCIAHGATFLTHSSHKHFLYGLPNEEQGGVQGSG
Protein: Ribosomal protein S1 (Ribosomal protein small subunit 1) (Q2F963)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MFLVDAGLGTPKICMQDELTGLPIKRATRFENKVGSKNVVAGESLIKKRIEERFFIDLVAGESLIKERAAARFNDFVGSLDVAAGEPLLLPQRFRQNRAWIELKKIWQTKKKVKGFRIKKIKGGYSVAIAGFITFLPFAKKKKRIANDRFTIDSFNPKRRDIVIIAADQTRT
Protein: 1,3-propanediol dehydrogenase (EC 1.1.1.202) (1,3-propanediol oxidoreductase) (3-hydroxypropionaldehyde reductase) (P45513)
Organism: Citrobacter freundii
Function: Catalyzes the reduction of 3-hydroxypropanal. Is considerably less active with glyceraldehyde, propionaldehyde, acetaldehyde, and butyraldehyde. Also catalyzes the oxidation of various primary, secondary, and tertiary alcohols. Is most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. 1,3-propanediol is the preferred substrate.
Interaction partners:
- Aldehyde dehydrogenase
- Glycerol dehydratase large subunit
- Glycerol dehydratase 21 kDa subunit
- Diol dehydratase small subunit
- Propanediol utilization protein
- Propanediol dehydratase
- Propanediol dehydratase
- Propanediol dehydratase
- Aldehyde dehydrogenase
- Uncharacterized 15.0 kDa protein in dhaT-dhaS intergenic region
Sequence:
MSYRMFDYLVPNVNFFGPNAISVVGERCKLLGGKKALLVTDKGLRAIKDGAVDKTLTHLREAGIDVVVFDGVEPNPKDTNVRDGLEVFRKEHCDIIVTVGGGSPHDCGKGIGIAATHEGDLYSYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVLTNTKTKVKFVIVSWRNLPSVSINDPLLMLGKPAPLTAATGMDALTHAVEAYISKDANPVTDAAAIQAIRLIARNLRQAVALGSNLKARENMAYASLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAVLLPHVARYNLIANPEKFADIAEFMGENTDGLSTMDAAELAIHAIARLSADIGIPQHLRDLGVKEADFPYMAEMALKDGNAFSNPRKGNEKEIAEIFRQAF
Protein: Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266) (Q9NP84)
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 12
- TNF receptor-associated factor 3
- TNF receptor-associated factor 2
- TNF receptor-associated factor 5
- Tumor necrosis factor receptor superfamily member 25
- Tumor necrosis factor
- TNF receptor-associated factor 1
- Baculoviral IAP repeat-containing protein 2
- Baculoviral IAP repeat-containing protein 3
- Tumor necrosis factor receptor superfamily member 1A
Sequence:
MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGEGCPAVALIQ
Protein: Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (TSLC1-like protein 1) (Q99N28)
Organism: Mus musculus (Mouse)
Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14659875, ECO:0000269|PubMed:15741237, ECO:0000269|PubMed:15893517, ECO:0000269|PubMed:33889941}; Single-pass type I membrane protein {ECO:0000269|PubMed:15893517}. Cell junction {ECO:0000269|PubMed:14659875, ECO:0000269|PubMed:15741237, ECO:0000269|PubMed:15893517}.
Interaction partners:
- Cell adhesion molecule 4
- Nectin-3
- Nectin-1
- Cell adhesion molecule 1
Sequence:
MGAPSALPLLLLLACSWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVSSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKETATLNCQSSGSKPAAQLTWRKGDQELHGDQTRIQEDPNGKTFTVSSSVSFQVTREDDGANIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPEPAHPREGQKLLLHCEGRGNPVPQQYVWVKEGSEPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYTAYFTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLILLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI
Protein: Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) (P07882)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P19835}.
Interaction partners:
- Pancreatic triacylglycerol lipase
- Inactive pancreatic lipase-related protein 1
- Chymotrypsinogen B
- Chymotrypsin-like elastase family member 2A
- Carboxypeptidase A1
- Chymotrypsin like elastase 3B
- Cationic trypsin-3
- Proteasome 20S subunit beta 10
- Pancreatic lipase-related protein 2
- Gastric triacylglycerol lipase
Sequence:
MGRLEVLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPDDPINLYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPPEDDSEAAPVPPTDDSQGGPVPPTDDSQTTPVPPTDNSQAGDSVEAQMPGPIGF
Protein: Uncharacterized protein (Q86BL9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Prolyl 4-hydroxylase alpha subunit domain-containing protein
- IP08087p
- FI16633p1
- procollagen-proline 4-dioxygenase
- HDC01001
- SCP domain-containing protein
- Sulfhydryl oxidase
- Hat-trick, isoform D
Sequence:
MARSISYSFKRLIVSFLAVTLICLWSMNSSRVDENFSARDSQEVEKLFYVESGKCKMRYVNPFNAEFLKINHPKAFIPCTNESDLISVHYDKILNQYVLHTNEEVLHELSESKTNDFACFYQKIIYGQSAEHYDGKGVKTKISQNHLVPLDVEGMLVECRTADEMRVLQRDAFVFVQYKDPPQNVKPVKKASVIMYGIDTVSRTNLRRMMPMVFEFLKSPGWYEMMGYNKVADNSFPNIFAMLTGFSPESAETQICNTDVDGCLDKIPFIWKDFKKDGYLTAYAEDEEHSNTFNYAKPGFAVKPTDYYFRPFLTALENETFIQYCPGCVMKYCLGRRLASSYIFDYCRQFMQRFVADRPIWGMFWTNHYSHDDLFMLSAMQHKILEDLLSFEKDGVFEHTIMIFFSDHGARFGPLMYTKEAFLEERLPMMFIYLPPWFRKKYPRYVEALAQNQNRLSSNFDLYNTLKHIINIEGLVEDTKWSYDCPQCQSLFYPLPESRSCSEAAIPEAYCTCHNYEEIKEDQGTWRLANLVVDRMNKYLHYHNLQNLCSNLTLRVINSTEVRMDDKDVDLANGMRHYHTKFQVHQNLAEFFATVLYDKQTEELQMNVELISRTNMYGTDSECVNNKIQKLYCVCLSKLRAIIK
Protein: SCP1-like small phosphatase 4 (F4KHG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- RNA polymerase II C-terminal domain phosphatase-like 5
- Transcription factor GTE9
- U-box domain-containing protein 35
- At5g17540
- Mitotic checkpoint protein BUB3.1
- U-box domain-containing protein 33
- Receptor-like serine/threonine-protein kinase ALE2
- Fatty acid amide hydrolase
- Phosphatidate phosphatase PAH2
Sequence:
MPYIEMKSKISKVLGVCKKHKASTRNSCSLSKISGDLESITAAITTCHDDEKQHPVSSGLDTFSRESETNEPAEMLVEDTSQSQGFAPWVDGSQSVENMENACNHMSNSDTIFSPVLNDELDGTGRVFTAGNSVIWETPRWGADESSNKICFDNQTCNVSDFYISDVLIASLPFDESGNNDAFTEISPLPHYIFPEQYMVLPYLEDGSANKDDIKSDTDKINLDNHDLFLAFNRTRSYNVEPDDRAESEVAEDFDPQLFIKNQPELSDVVSNYWPRDTLRKKSVTLVLDLDETLVHSTLESCNVADFSFRVFFNMQENTVYVRQRPHLYRFLERVGELFHVVIFTASHSIYASQLLDILDPDGKFISQRFYRDSCILLDGIYTKDLTVLGLDLAKVAIIDNCPQVYRLQINNGIPIKSWYDDPTDDGLITILPFLETLAVADDVRPIIGRRFGNKE