Protein: Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) (Q3URD3)
Organism: Mus musculus (Mouse)
Function: May play a role during myoblast fusion.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:15086317, ECO:0000269|PubMed:15591093}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15086317, ECO:0000269|PubMed:15591093}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:15086317}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:15086317}. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. {ECO:0000269|PubMed:15086317}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15126628}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Note=Localizes to the centrosomes in a microtubule-dependent manner. {ECO:0000269|PubMed:15126628}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15126628}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Note=Localizes to the centrosomes in a microtubule-dependent manner (PubMed:15126628). Do not localize at the mitochondrial membrane (By similarity). {ECO:0000250|UniProtKB:Q14BN4, ECO:0000269|PubMed:15126628}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Note=Do not localize at the mitochondrial membrane. {ECO:0000250|UniProtKB:Q14BN4}.
Interaction partners:
- Suppressor of IKBKE 1
- Striatin-interacting protein 1
- Striatin-3
- Programmed cell death protein 10
- Serine/threonine-protein kinase 25
- Serine/threonine-protein kinase 24
- MOB-like protein phocein
- Striatin-interacting proteins 2
- FGFR1 oncogene partner 2 homolog
- Striatin
Sequence:
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTSKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHSYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQTKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKECSSLGIQVDDFLPKINGSTEKEHLLSKSGGDCTFIHQFLECQKKLMVQGHLTKVVEESKLSKENQAKAKESDLSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGTQSETEAKQDIQHLRKELVEAQELARTSKQKCFELQALLEEERKAYRNQVEESAKQIQVLQVQLQKLHMDMENLQEEKDTEISSTRDKLLSAQDEILLLRQAAAEAVSERDTDFVSLQEELKKVRAELEGWRKAASEYENEIRSLQSSFQLRCQQCEDQQREEATRLQGELEKLKKEWDVLETECHSLKKENVLLSSELQRQEKELHNSQKQSFELTSDLSILQMTRKELEKQVGSLKEQHLRDAADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKDNLKLLREKGNNKPWPWMPMLAALVAVTAMVLYVPGLARASP