wanglab/gogpt-training-data huggingface dataset:
Protein: Rho-type GTPase-activating protein 1 (P39083)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection.
Interaction partners:
- Cell division control protein 42
- Serine/threonine-protein kinase CLA4
- Rho-type GTPase-activating protein 2
- GTP-binding protein RHO1
- Ras-related protein RSR1
- Cell division control protein 24
- Dual specificity protein kinase YAK1
- GTPase-interacting component 2
- GTP-binding protein RHO3
- Bud emergence protein 1
Sequence:
MASTAPNEQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCLSCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRRSKDLMINLKSRATGKQDSNVKLSPASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRHIESYNSEKNKLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVSTNNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMGQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVAFIFGNYKDILT
Protein: At2g32650 (Expressed protein) (RmlC-like cupins superfamily protein) (O48852)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASLIMTTPFPGSVTACKKTNNLSVQRAFKVTCMQTEKPLEELYNVKVERKVSQKRLEELGVSRWSVWKTGKCKLPWDWQVDQLVYIEQGEVRVVPEGSKRYMQFLAGDLVRYPKWLEADLFFNAPYIERYCFKAYGDD
Protein: Jacalin-related lectin 5 (Q9ZU23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Plant self-incompatibility protein S1 family
- F14J9.2 protein
- Putative purine permease 19
- Pentatricopeptide repeat-containing protein At5g12100
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Regulator of Vps4 activity in the MVB pathway protein
- Protein trichome birefringence-like 26
- Plant self-incompatibility protein S1 family
- GDSL esterase/lipase At1g54020
- Auxin-responsive protein SAUR77
Sequence:
MSWDDGKHTKVKRVQLTFDDVIRSIEVEYDGTSLKSQPRGTAGTKIDGFTLSSDEYITEVNGYYKTTFSGEVITSLTFKTNKRTYGTYGNKTSSYFSVAAPKDNQIVGFLGSSSHALNSIDAHFAPAPPPGSTGAKPGASGIGSDSGSIGSAGTNPGADGTRETEKNAGGSKPSSGSAGTNPGASAVGNGETEKNAGGSKPSSGSAGTNPGASAGGNGETEKNVGGSKPSSGKAGTNPGANAGGNGGTEKNAGGSKSSSGSARTNPGASAGGNGETVSNIGDTESNAGGSKSNDGANNGASGIESNAGSTGTNFGAGGTGGIGDTESDAGGSKTNSGNGGTNDGASGIGSNDGSTGTNPGAGGGTDSNIEGTENNVGGKETNPGASGIGNSDGSTGTSPEGTESNADGTKTNTGGKESNTGSESNTNSSPQKLEAQGGNGGNQWDDGTDHDGVMKIHVAVGGLGIEQIRFDYVKNGQLKEGPFHGVKGRGGTSTIEISHPDEYLVSVEGLYDSSNIIQGIQFQSNKHTSQYFGYEYYGDGTQFSLQVNEKKIIGFHGFADSHLNSLGAYFVPISSSSSSLTPPPNKVKAQGGSYGETFDDGAFDHVRKVYVGQGDSGVAYVKFDYEKDGKKETQEHGKMTLSGTEEFEVDSDDYITSMEVYVDKVYGYKSEIVIALTFKTFKGETSPRFGIETENKYEVKDGKGGKLAGFHGKASDVLYAIGAYFIPAAN
Protein: Phosphoglucomutase-2 (O45934)
Organism: Caenorhabditis elegans
Interaction partners:
- phosphoglucomutase
- Putative deoxyribose-phosphate aldolase
- Alpha-1,4 glucan phosphorylase
- Glucose-6-phosphate isomerase
- Probable-ribose 5-phosphate isomerase
- Probable ADP-dependent glucokinase
- Ribokinase
- UTP--glucose-1-phosphate uridylyltransferase
- ribose-phosphate diphosphokinase
- transketolase
Sequence:
MTLGCAKLDKQVADWLAWDKNDKNRNEIQKLVDEKNVDALKARMDTRLVFGTAGVRSPMQAGFGRLNDLTIIQITHGFARHMLNVYGQPKNGVAIGFDGRYNSRRFAELSANVFVRNNIPVYLFSEVSPTPVVSWATIKLGCDAGLIITASHNPKEDNGYKAYWSNGAQIIGPHDTEIVRIKEAEPQPRDEYWDLSELKSSPLFHSADVVIDPYFEVEKSLNFTREINGSTPLKFTYSAFHGIGYHYTKRMFAEFGFPASSFISVAEQQDPNPDFPTIPFPNPEEGRKVLTLAMETADKNGSTVILANDPDADRIQMAEKQKDGEWRVFTGNEMGALITWWIWTNWRKANPNADASKVYILNSAVSSQIVKTIADAEGFKNETTLTGFKWMGNRAEELRADGNQVILAWEESIGYMPGHTMDKDGVSAAAVFAEIAAFLHAEGKSLQDQLYALYNRYGFHLVRSTYWMVPAPEVTKKLFSTLRADLKFPTKIGEAEVASVRDLTIGYDNSKPDNKPVLPLSTSSEMVTFFLKTGSVTTLRASGTEPKIKYYIELITAPGKTQNDLESVISEMDQLEKDVVATLLRPQQFGLIPRK
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q580P5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MESRPDTKGMCHATVAATVPVLFMTLMRCGMAQTVTEPSSDKVTNLCTEAKYTEYLASRIVAVAERQEREISDMQIYSEAWNLLAASTNQTDKRAATYALATYMSTAAETARRAHAGKYKAAVATAKLLHRRSALTRTLLTMRIRGKTIVGISKEANGIGICPGEATPTLSGDSSCAHRTNDSNQPEGIAVNLKAATHIKLLNSSALRPRGLTHLVEIKETKWPASREALVERCGGLLGGDHYVKFEASTTGEDSKIIVEPIKIFEGDDAEKNCAVVQKESMKSEKDNDLLINKICTYITILDPQIITISSLTPAMLANTSTVQMAFKSFVHAATGKAPSDGEIELQLKSLYGGDKQNFTRDFVKILWTKNVTYHTGAGFKTETLLDAVRNKNAQRALIYLEDQRPAEESKQTQTDESEINGPVCGGEGQEECKLDEKKDPEKPNGTQMRKWPKALQWMITRQGGNCKTIQQEDCKEDCTWDEGACDGAVGISASMNISLFMAFLLLA
Protein: T-cell surface glycoprotein CD1c (CD antigen CD1c) (P29017)
Organism: Homo sapiens (Human)
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:3097645}; Single-pass type I membrane protein. Lysosome {ECO:0000269|PubMed:10890914}. Note=Subject to intracellular trafficking between the cell membrane and endosomes. {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:3097645}.
Interaction partners:
- Beta-2-microglobulin
- CD83 antigen
- C-type lectin domain family 4 member K
- T-cell surface glycoprotein CD1b
- C-type lectin domain family 4 member C
- Thrombomodulin
- T-cell surface glycoprotein CD4
- Macrosialin
- Integrin alpha-X
- T-cell surface glycoprotein CD1a
Sequence:
MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPAGLSCRVRHSSLGGQDIILYWGHHFSMNWIALVVIVPLVILIVLVLWFKKHCSYQDIL
Protein: Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) (P53449)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Triosephosphate isomerase
- Transketolase
- Glyceraldehyde-3-phosphate dehydrogenase
- Fructose-bisphosphatase 2
- FBPase domain-containing protein
- 6-phosphofructokinase
- Uncharacterized protein.
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Transaldolase
Sequence:
LLKPNMVTPGHSCPTKYSPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASINLNAINTCPLVRPWALTFSYGRALQASALSAWRGQRDNANAATEEFVKRAEVNGLAALGKYEGSGDDSGAAGQSLYVANHAY
Protein: T cell receptor beta, variable 26 (A0A0B4J1P5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MATRLLCYTVLCLLGARILNSKVIQTPRYLVKGQGQKAKMRCIPEKGHPVVFWYQQNKNNEFKFLINFQNQEVLQQIDMTEKRFSAECPSNSPCSLEIQSSEAGDSALYLCASSL
Protein: Protein phosphatase 2C, putative (AFU_orthologue AFUA_1G15800) (Q5BEW6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Acetyltransferase, GNAT family family
- 3-methyl-2-oxobutanoate dehydrogenase
Sequence:
MTLAPSKRVTVRVWTLIDSQNYIRFYRCRYSSTTQAAESTRTTKRREFHDYFVTHLPSSSLHPDPRGPLTSFHKLPRSASVPHTGESTHSPTSFQALTSRETTVVRIPLRSAKHHFGAATSRGTRPSNEDTYQAGVIDIPAFAKRPPASLTIRNRSARVAGLRENRGADSASGDPQVFYFGIFDGHGGSECSTFLKETLHEYIQDTAAEFELQSSLRKAGENSASPDAESELPIRQGSNVARVQRLEKSLVQSWRNLVGGYFRRFVPPNFSHLAKHTAEESSSVPENNKGVTIEEILEYAFLRADLDFVSAQASREDDELSNVCRPLYQDDILYGPSRSQSLNIAGLRRFKGGSTASTVLISTPTPAPFWHPASPSSLLVSHVGDTRILLCSTVTGEAIPLTSNHHPSSPIEANRLRRYAATFVTDSFGEERISGLANTRAFGDVQSKRIGVSAEPELRRFEIAPAEYSFLVLMSDGISEALTDQEVVDIIKEAKTPDEGARHVVNFATEVTRTGDNATCLVVRLGGWERRLEGGLGSLGTKESREFRRQEATDPRRSRR
Protein: Myelin-oligodendrocyte glycoprotein (Q61885)
Organism: Mus musculus (Mouse)
Function: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Myelin basic protein
- Myelin-associated oligodendrocyte basic protein
- Myelin-associated glycoprotein
- H-2 class II histocompatibility antigen, A beta chain
- Myelin proteolipid protein
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
- T-cell surface glycoprotein CD4
- Opalin
- Reticulon-4 receptor
- Aquaporin-4
Sequence:
MACLWSFSWPSCFLSLLLLLLQLSCSYAGQFRVIGPGYPIRALVGDEAELPCRISPGKNATGMEVGWYRSPFSRVVHLYRNGKDQDAEQAPEYRGRTELLKETISEGKVTLRIQNVRFSDEGGYTCFFRDHSYQEEAAMELKVEDPFYWVNPGVLTLIALVPTILLQVPVGLVFLFLQHRLRGKLRAEVENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFLEELRNPF
Protein: Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) (Q9EQG6)
Organism: Rattus norvegicus (Rat)
Function: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Late endosome {ECO:0000269|PubMed:10998417, ECO:0000269|PubMed:17724123}. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Interaction partners:
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- High affinity nerve growth factor receptor
- Crk-like protein
- Adapter molecule crk
- BDNF/NT-3 growth factors receptor
Sequence:
MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMLAAEQGNVEIVKELLKNGANCNLEDLDNWTALISASKEGHIHIVEELLKSGASLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHIEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHVAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQTEPLFQFSWLIVFLTLLLCGGLGLVFAFTVDTNLAIAISLSFLALIYIFFIVIYFGGRREGESWNWAWALSTRLARHIGYLELLFKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFRTEESQGKKKWKKTCCLPSFVIFLFIVGCIIAGITLLAIFRVDPKHLTVNAILISIASVVGLAFVLNCRTWWQVLDSLLNSQRKRLHSAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDITCSDTTGTQEDTDRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQITFNWDRLASWINLTEQWPYRTSWLILYLEETEGLPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKTFLPCTVNLDPKLREIIADVRAAREQINIGGLAYPPLPLHEGPPRPPSGYSQPASVCSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSSVKTSLPRDQNNGLPCDSGFNKQRQAAVPATGSSLLLSSMTVDVVCEKLRQIEGLDQSMMPQYCTTIKKANINGRVLSQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVESQVVPEDPRFLNENSSAPVPHGESARRSSHTELPLTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSTLEQERGKEGELKQEDGRKSFLMKRGDVIDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGGGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVCKSPEHSAEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEESWPACQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGIRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSESTGFGEERESIL
Protein: Fibrous sheath-interacting protein 1 (Q9D3V5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPMDIIKGNLDGISKPASSSRSRPGSRSSNGSLEVLTPEPGSVKIDMVNKLNSGQEGHTSNSGVEERRNSNDAKWADDSKTKPAKESSDEDPDMPQPQATPEHSDDPKLEETNAVLQNAIRKMHRLDKLLAKKQCREKEVKKQGLEMRVKLWEELKSAKNTEDLENDEELGNTKKFLCLTSESAGKAAAEALHCEFEDALFSVFHTQIPPETYENLMEKDFTCDVEKNEPLIITEKQPFSNTEAIEPRSEDSQGFIRQNAEHSQDFIKRNIELAKHSRSPVVMVEGEKKRLDELLQGLDDADSGLSSAEGDQCGWLVPGEGYTLAATESQQLAEIDIKLQELSVDSPTIFSLESQSHKGDMECDANEERNTEPTPGEKILRDRKEQRDRESRLRAIDGKLKELSEQVEECPMITPSKRNERITWRWLLAKILEPE
Protein: Uncharacterized protein C191.06 (Q9Y7Q0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MSHLFILSCSVYDFSSILLHQYFTQFFVLRYASPSMHLDWRFPSLRIHSYPKDQSTHAWKMHCMPTEIIAYQPIPVFQRLLHSNDIYFPYFQTRYTTLIMFNTVCSSSPNPVFTLTKVIARKKGKHWIGSPCHSAESS
Protein: Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127) (P16872)
Organism: Mus musculus (Mouse)
Function: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Thymic stromal lymphopoietin
- Cytokine receptor common subunit gamma
- Cytokine receptor-like factor 2
- Interleukin-7
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK3
- Interleukin-15
- Interleukin-2
- T-cell surface glycoprotein CD4
- Signal transducer and activator of transcription
Sequence:
MMALGRAFAIVFCLIQAVSGESGNAQDGDLEDADADDHSFWCHSQLEVDGSQHLLTCAFNDSDINTANLEFQICGALLRVKCLTLNKLQDIYFIKTSEFLLIGSSNICVKLGQKNLTCKNMAINTIVKAEAPSDLKVVYRKEANDFLVTFNAPHLKKKYLKKVKHDVAYRPARGESNWTHVSLFHTRTTIPQRKLRPKAMYEIKVRSIPHNDYFKGFWSEWSPSSTFETPEPKNQGGWDPVLPSVTILSLFSVFLLVILAHVLWKKRIKPVVWPSLPDHKKTLEQLCKKPKTSLNVSFNPESFLDCQIHEVKGVEARDEVESFLPNDLPAQPEELETQGHRAAVHSANRSPETSVSPPETVRRESPLRCLARNLSTCNAPPLLSSRSPDYRDGDRNRPPVYQDLLPNSGNTNVPVPVPQPLPFQSGILIPVSQRQPISTSSVLNQEEAYVTMSSFYQNK
Protein: BTB/POZ domain-containing protein KCTD17 (Q8N5Z5)
Organism: Homo sapiens (Human)
Function: Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. May be involved in endoplasmic reticulum calcium ion homeostasis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25983243}.
Interaction partners:
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- BTB/POZ domain-containing protein KCTD2
- BTB/POZ domain-containing protein KCTD5
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
- Kelch-like protein 3
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
- Kelch-like protein 12
- Speckle-type POZ protein
- Kelch-like protein 20
Sequence:
MRMEAGEAAPPAGAGGRAAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELHSTPNGLSSESSRKTKSTEEQLEEQQQQEEEVEEVEVEQVQVEADAQEKAQSSQDPANLFSLPPLPPPPLPAGGSRPHPLRPEAELAVRASPRPLARPQSCHPCCYKPEAPGCEAPDHLQGLGVPI
Protein: C2H2-type domain-containing protein (tRNA isopentenyl transferase) (G5EBS1)
Organism: Caenorhabditis elegans
Interaction partners:
- Guanine nucleotide-binding protein alpha-2 subunit
- Hflx-type G domain-containing protein
- GTP exchange factor for ARFs 1
- Aminopeptidase ltah-1.1
- Putative tRNA
- Protein Fe65 homolog
- Guanine nucleotide-binding protein alpha-6 subunit
- Guanine nucleotide-binding protein alpha-5 subunit
- Trifunctional purine biosynthetic protein adenosine-3
- GrpE protein homolog
Sequence:
MIFRKFLNFLKPYKMRTDPIIFVIGCTGTGKSDLGVAIAKKYGGEVISVDSMQFYKGLDIATNKITEEESEGIQHHMMSFLNPSESSSYNVHSFREVTLDLIKKIRARSKIPVIVGGTTYYAESVLYENNLIETNTSDDVDSKSRTSSESSSEDTEEGISNQELWDELKKIDEKSALLLHPNNRYRVQRALQIFRETGIRKSELVEKQKSDETVDLGGRLRFDNSLVIFMDATPEVLEERLDGRVDKMIKLGLKNELIEFYNEHAEYINHSKYGVMQCIGLKEFVPWLNLDPSERDTLNGDKLFKQGCDDVKLHTRQYARRQRRWYRSRLLKRSDGDRKMASTKMLDTSDKYRIISDGMDIVDQWMNGIDLFEDISTDTNPILKGSDANILLNCEICNISMTGKDNWQKHIDGKKHKHHAKQKKLAETRT
Protein: Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (mVDAC3) (Outer mitochondrial membrane protein porin 3) (Q60931)
Organism: Mus musculus (Mouse)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}. Membrane {ECO:0000250|UniProtKB:Q9Y277}. Note=May localize to non-mitochondrial membranes. {ECO:0000250|UniProtKB:Q9Y277}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC2
- ADP/ATP translocase 1
- Non-selective voltage-gated ion channel VDAC1
- Cytochrome c, somatic
- ADP/ATP translocase 2
- Cytochrome c, testis-specific
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Translocator protein
- Peptidyl-prolyl cis-trans isomerase D
- ADP/ATP translocase 4
Sequence:
MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYRRDCFSLGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNERIETSINLAWTAGSNNTRFGIAAKYKLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFNAGGHKVGLGFELEA
Protein: Bromodomain testis-specific protein (D4A7T3)
Organism: Rattus norvegicus (Rat)
Function: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:22215678}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q91Y44}.
Interaction partners:
- Cyclin-dependent kinase 9
- Beta-defensin 1
- Cyclin-T1
- Histone H4
- Cyclin T1
- Bromodomain-containing protein 2
- Bromodomain containing 3
- Bromodomain containing 4
- Histone-lysine N-methyltransferase NSD3
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Sequence:
MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQIVGGKERMKKDIQQKTAVSSAKEQTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQEAPPTCDSQTVVQITKGVKRRADTTTPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIKGKMDKQEYKDACEFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACHLTTNSAKALSRESSSEASSGDCSSEDSEDERVQRLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNRDENPKKKAKQMKQKEKAKSNQPKKKKPLLKLEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPHAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVAVSPRPPLPPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSSSSGSGSSSSDSSSSDSSDSEPEISPKFTGVKQNDLPSKENTKQIQCSVPDITSAETALVQQSTGPCGAPGKPPQQMPGCQVPHHLQATESTASVQTQPLAGDCKRVLHGPPVVHASAESHTVLELQCHAPVQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKVSQESQREFGSGFTPESSSNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
Protein: Peroxidase 38 (Atperox P38) (EC 1.11.1.7) (Q9LDA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000305}. Vacuole {ECO:0000305}. Note=Carboxy-terminal extension appears to target the protein to vacuoles.
Interaction partners:
- Berberine bridge enzyme-like 7
- Uncharacterized protein At1g21520
- Berberine bridge enzyme-like 6
- Large ribosomal subunit protein uL18c
- Thioredoxin H8
- Thioredoxin H7
- Berberine bridge enzyme-like 4
- Peroxiredoxin-2C
Sequence:
MHSSLIKLGFLLLLLQVSLSHAQLSPSFYDKTCPQVFDIVTNTIVNALRSDPRIAASILRLHFHDCFVNGCDASILLDNTTSFRTEKDAFGNANSARGFDVIDKMKAAIEKACPRTVSCADMLAIAAKESIVLAGGPSWMVPNGRRDSLRGFMDLANDNLPGPSSTLKQLKDRFKNVGLDRSSDLVALSGGHTFGKSQCQFIMDRLYNFGETGLPDPTLDKSYLATLRKQCPRNGNQSVLVDFDLRTPTLFDNKYYVNLKENKGLIQSDQELFSSPDAADTLPLVRAYADGQGTFFDAFVKAIIRMSSLSPLTGKQGEIRLNCRVVNSKSKIMDVVDDALEFASFM
Protein: Rdh9 protein (Retinol dehydrogenase 9) (Q6PHA1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MWLFLVALVGLWTLLCFFRERQVVSYLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKERVGNRGKVHSYLAFGPPPGRR
Protein: Transcriptional regulator SarA (Staphylococcal accessory regulator A) (Q2FJ20)
Organism: Staphylococcus aureus (strain USA300)
Function: Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
Protein: Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Hypoxia-inducible factor asparagine hydroxylase) (P59723)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NWT6}. Cytoplasm {ECO:0000250|UniProtKB:Q9NWT6}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NWT6}.
Interaction partners:
- Hypoxia-inducible factor 1-alpha
- Neurogenic locus notch homolog protein 1
- Notch receptor 1b.
- Hypoxia-inducible factor 1-alpha
- Poly [ADP-ribose] polymerase
- Poly [ADP-ribose] polymerase
Sequence:
MAETDGAAAFTELRDPDWDESQLRQYTFPTRQIPRLSHTDPRAEVLINNEEPVVLTDTSLVYPALKWDIPYLQENIGNGDFSVYIAENHKFLYYDEKKMVNFQDFVPKSRRIEMKFSEFVDKMHQTEEQGGKGRVYLQQTLNDTVGRKIVVDFLGFNWNWINKQQAKRNWGPLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCILFPPDQFDCLYPYPVHHPCDRQSQVDFENPDYDKFPNFKNAVGYEAVVGPGDVLYIPMYWWHHIESLLNGGETITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGDPHEVGPLLNMMIKGRYDHGLS