Protein: Mediator of RNA polymerase II transcription subunit 13 (Aggregation minus B protein) (Mediator complex subunit 13) (Q54S20)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for the starvation-induced activation of the ACA (adenylyl cyclase) expression pathway at the growth/differentiation transition.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- isocitrate lyase
- malate synthase
- ADF-H domain-containing protein
Sequence:
MMGTKVPSYNNKQQSGSNAGGNVNNNNNGPNINNPNNPNNTNSLPTTSGYNSSRFSVPNLDTDNFMTNIISMGVNKVGWALYRSNSNNNNNNINNNSSSSSSSNTSNNINSNTLVNDPILLAYLKTIELGVPCLWRKTRSKKPINNSSNNSNITSSTSTDSSLKNRLKNSPSETTPPNTTNNNSNNVTKDSPPNATNKMSTSPKSLSPTISNNNNNTTAAATTTTTTTNNSSNSPTSPTNNNNNNNNNNSPSSHNVVNSPPSTSSRSPPTVASVTSNTSTIQPISPIINRQTSSHNYQQPQQPYYNHQPLQPIQEYITTYELWVFNISNTSLLDFSHLNNVESGIVNLDNIGCNNSVIVQYLFKSLYNLVEYNMVSNDFIKIGNSFIKSSHILQKQKQSRNDYNNSIISGSVGSKKRLFEDFTNLYIEDDCLLSCSFSFFIYNKSIHLHFNVDKKRLKPLQELMKSEYINSPLFTSPNAFIAFFNNNNKNNINNNSNNIINNNNNSNINNNINNNNNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTINNNSNNISSNNDNNNTPSQMVPSIDGHDSSSSSSTPSQVTMQTTPTQEFSNNNNNNISINTTTVPITATTATATNKITTAATTTTTINNNNNKIQTESFGSTRNKKLNDEEEINFSLSSQQWKQLFNIGLANKAIIPKQQTPQQQEQQQIIGTIFKKNQLEVPKSIKTIITRGNSLPLINTFFPIELLFKFFPPISDISQYTYHEKLKEFGLEIFDKSPYALLEKGLNLFINNNNINIENNNNTSNEINNTGTQIPTKYKYVDFWSLPLFHSKESLIYGNDHFNATYCVKAVPSPSSPLTQHPSSPHSPFNNVNSPKSPQHPPSPKTPMISDDDQSLTANNEKKRHGKSQKKGRSSKRKKDDNSNNNNNNNTTTTSTITATTTTTTPTAATTGNDNFLAPQSKPPPSNIQETSQPQSLTTVQPQPPPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVVSSFSGQGLNSSMDLFGSDAFDTFKNKEDDLMHLSDTDIDLDLWTSHYVPPNQPTQNGSQKNNQRPLPVEDPFQVFQVPNKPATTTTTTTTTTTPTPNPTTTTTQPQTQPQQQSQQQQQPQQTNPILPTNSNLITNQKPQQYQPPLQDPFQSIDSQQPKSIQSPTLTNQPIGMVSPTLTNQPLQQYQPPPPPTQQPQQAHLKPPPPKQPSAKKNSKDGINSDENKPFLDGQFLCPVPYKAPSLSQNQLPILHLPHNTEQSPSNDDLSNPNHLHHGTPTSAISGVGGSSSSSGNNMIGSGGIVGSGGGNTNVSGSGGGMVSDPSKLTYSSEHHDPHHHHHHHHHHHPQNSQNLRNSYGNSNGVGGSQDESIDGLTTVYRNLTLSRPLGDNKNKNNAPYYCAPSYKPLDEHSLPHQLKFEYSYTPLVKPQNQLNQTKYSPFSNSHHNHHHNTTTNNNNNHNNNNNNNHPNNHHQNNNHHHLNITSSLFQPSNIQNVNSLPNIGSQKIMSISPPITPPMKGGHMIGTDINKNNNKKNNDEDENLEILSTIKQKDVNGLDSNLSSSALLSFFDQAINIKTTPPRSPVLSGYSGGGSNMNNGINGNSGFIGNGNSGFNTISSYQQNNISIEESLDLAFTIQQMTITNYDSTFGFSIDNSPLIKQSIDYYLENWLKIYTETGKVFNHHSLQFLTEESISDALDTVIDPLTTNTILETTVKTLFTFSNEIFKKIFPLSSFPLSIKEFCHLPSITLNNINNNIDLLNSQTYQNTNNSSSGGGIESQQYFSGSSGLNNSNDRNSMIPMDNSDDTSDLMSMDDHNSKNLITGTSLISTTASGAGAAITTNLINQNYEEFEWLPIPKIIVGYKEDWLEVPISTIKFWDKAQLEPYSPKKNITYFVLCPDTTAMRMHVPAFFSDLSCIYETNHLGNHVTQQQSQVQQAAAAAVAASQPTQQSSQHQSQQQQQQAAQQAAAAAAAAAAAQKNSSPFYNGIYYIPSAANTEFNPQTFINSYLLTCIQFGDYLKELSTKYSENNCMVLYIVNPFSDLSQISLSNQNQNQNQNSNSNESQQQQQQQSNNKQKQTQTNEDINHIRNSYLFMSSCFQTIVRDITCNQSLSITIQTIPIEQILFDDHPSIPVSKELAFSVFNKCRRISTISPMNFSINMNNINNMIGNNNSNSNNSSGWYYQLFNKIYEPLFILSNESSSSSSSTISTSTSASTSTSTSNTTTKNQQQQSQSQQSQQQSQQPKQLSTPTTPTTNSVSNSPSLQPQPLQTPNQLQPHQQEQKQQQQIPIIHFSYMLSDDNKWISCTIVDEQGELLENKLIPLAYSQIIGDYIWKDSFQNAWFFLTEIIGLSLSGQPCQVVIGKFGIISMQEYNDWKTTIIHFEDNLEVIKQHQQQSQSQNYSSTIDQIYKIENVIFLNLTLNNNIKSFLTEYLNDSKLSNSNNIKSVSPLSGQSFAIYPESPIMYTYNFPMNDNNDDYNSILNNNNNNILPPLSTSFVITSPSNLSGSVLTPTTTNSNVINNNQSKKEWPFTYMLSIVGIQSLQHQQQQQQQQQQQQQQQHPNIINHQELIRSITRSYHRLSYLNISPRYPDRLSILPIHFSISKRMSRTVCLISPLNPIPPPILFNRCPKLTPNSKQSPSPINSPHLNSNNT