wanglab/gogpt-training-data huggingface dataset:
Protein: Acetyl-coenzyme A transporter 1 (Solute carrier family 33 (Acetyl-CoA transporter), member 1) (Q7SXX6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MELSESLTHKNGRQRKPVLLNSDMGERESKLEVGGDEEALLPNSDRADGRTQTHKGIKGELGNVSLLLFLYVLQGIPLGLAGSIPLIMQSKNVSYKDQAYFSFVFWPFSLKLFWAPLVDSVYLKQFGRRKSWLVPTQYLLGLFMLYLSLTVDSMLQTDGQKGPDVITLTAVFFLLAFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFEPQERGIVTLSDFLFFWGIVFMVSTTLVAVLKKENGKPHPAKKKPKEETQGVKETYKLLFSIIKMPTVFTFCALLLTAKVGFSAADAVTGLKLVEAGVPKEQLALLAVPMVPLQILLPLVISKYTAGPRPLDIFYKAFPFRLLIGLEYALLVWWTPSVRQEEGFPVYYYAVVLLSYAVHQVALYSMYVACMAFHAKVSDPVIGGTYMTLLNTVTNLGGNWPSTLALWLVDPLTSKECHGAPGQTCSSIEEAGLCVREGGSCVTSLDGYYVESVVCVLIGLCWWIFFGKRMKRLQEESPSAWHCRVAK
Protein: LD24176p (Q8MSB9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMADRYASDLALVVVAQITQTIGYSCTLSAPLELLQDILQKFVQEFARDMHRHMEHANRIEPNLKDARLSIKNLSINVQELLDYIGNVEPVGFIRDVPQFPIGKSVNMNFLKPGSAETLTRPVYIFEYLPPMQDPELREIPADVQKEFSEKQEFCSKAEYSSTNAADKLGAKHIDSISPNTVINFRSNAFELDVGSSVREMSSVVMTTGGFISPAIEGKLPEDIIPDIVEKFLGLDAPFSPTIIVNSLQKSPQLALSDRDKTVNPRKIIPSETKIFKQNAALLTSGHSESSIIYASNNHTMLTVTTPKKNRKQKHDLICEPGQSELLTNPFEKAQEKSQRKALKMYKQTSKNQRDSSINQIQNMKKKKKK
Protein: ABC transporter G family member 26 (ABC transporter ABCG.26) (AtABCG26) (Putative white-brown complex homolog protein 27) (AtWBC27) (Q9LK50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the transport of sporopollenin precursors (e.g. polyketides) across the tapetum plasma membrane into the anther locule for polymerization on developing microspore walls, thus being required for male fertility and pollen exine formation and patterning prior to tapetum programmed cell death.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20732973, ECO:0000269|PubMed:21205178, ECO:0000269|PubMed:21223384}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20732973}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 703A2
- Type III polyketide synthase B
- Cytochrome P450 704B1
- Transcription factor DYT1
- 4-coumarate--CoA ligase-like 1
- Short-chain dehydrogenase reductase ATA1
- Type III polyketide synthase A
- Transcription factor MYB35
- 3-ketoacyl-CoA synthase 7
- Tetraketide alpha-pyrone reductase 1
Sequence:
MEIRRSTEEVEENHVMQITGSNGIVHNMEFMPQAYLRNQYSSEIDIDEEFVSTYPLEDAPLPIFLKFEDVEYKVRNSHASSANLVKTMVSKVVTHTNPDPDGYKHILKGITGSTGPGEILALMGPSGSGKTTLLKIMGGRLTDNVKGKLTYNDIPYSPSVKRRIGFVTQDDVLLPQLTVEETLAFAAFLRLPSSMSKEQKYAKIEMIIKELGLERCRRTRVGGGFVKGISGGERKRASIAYEILVDPSLLLLDEPTSGLDSTSATKLLHILQGVAKAGRTVITTIHQPSSRMFHMFDKLLLISEGHPAFYGKARESMEYFSSLRILPEIAMNPAEFLLDLATGQVSDISLPDELLAAKTAQPDSEEVLLKYLKQRYKTDLEPKEKEENHRNRKAPEHLQIAIQVKKDWTLSWWDQFLILSRRTFRERRRDYFDKLRLVQSLGVAVVLGLLWWKSKTDTEAHLRDQVGLMFYICIFWTSSSLFGAVYVFPFEKIYLVKERKAEMYRLSVYYVCSTLCDMVAHVLYPTFFMIIVYFMAEFNRNIPCFLFTVLTILLIAITSQGAGEFLGASVLSIKRAGMIASLVLMLFLLTGGYYVQHIPKFMQWLKYLSFMHYGFRLLLKVQYSADQLFECGSKGGCRTLQSSSSFDTINLNGGLQELWVLLAMAFGYRLCAYFCLRKKISICHL
Protein: Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9) (Q9NUM3)
Organism: Homo sapiens (Human)
Function: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19420709}. Cell membrane {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}. Mitochondrion {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}. Nucleus {ECO:0000269|PubMed:25014355}.
Interaction partners:
- Zinc transporter ZIP11
- Zinc transporter 7
- Zinc transporter SLC39A7
- Zinc transporter ZIP13
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter ZIP6
- Zinc transporter ZIP10
- Zinc transporter ZIP1
- Zinc transporter 6
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
Sequence:
MDDFISISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGNSHVHSTDDPEAARSSNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKPDATGGRGLSRLEVAALVLGCLIPLILSVGHQH
Protein: Amphiphysin (Q7TQF7)
Organism: Mus musculus (Mouse)
Function: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Dynamin-1
- Synaptojanin-1
- Dynamin-2
- Myc box-dependent-interacting protein 1
- Clathrin heavy chain 1
- Synaptojanin-2
- Intersectin-1
- Endophilin-A1
- Intersectin-2
- Epsin-1
Sequence:
MADIKTGIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGTRLQRELRGYLAAIKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKCDVLWEDFHQKLVDGSLLTLDTYLGQFPDIKNRIAKRSRKLVDYDSARHHLEALQSSKRKDESRISKAEEEFQKAQKVFEEFNVDLQEELPSLWSSRVGFYVNTFKNVSSLEAKFHKEIAVLCHKLYEVMTKLGDQHADKAFSIQGAPSDSGPLRIAKTPSPPEEPSPLPSPTASPNHTLAPASPAPVRPRSPSQTRKGPPVPPLPKVTPTKELKQENIINFFEDNFVPEINVTTPSQNEVLEVKKEETLLDLDFDPFKPDVAPAGSAAATHSPMSQTLPWDLWTTSTDLVQPASGGSFNDFTQAQDTSLFTMQTDQNMAETEQALPTEPQAEEPPATAAAPTAGLDLGLEMEEPKEEAVIPPATDTGETVETAVPTEGAPVEEAEAEKAALPAGEGGSPEGAKIDGESTELAISESPQPVEPEAGAPQVIPSVVIEPASNHEGEGEHQETATGTEPREAAEDVAAQGSAGEKQEVATEPTPLDSQATLPASAGAVDASLSAGDATQELPPGFLYKVETLHDFEAANSDELNLQRGDVVLVVPSDSEADQDAGWLVGVKESDWLQYRDLATYKGLFPENFTRRLE
Protein: COUP transcription factor 1 (A0A060YH15)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 1
- Uncharacterized protein
Sequence:
MAMVVSVWRDPQEDAASAAPHTPQTPSQPGPPSTPGTAGDKGSQNSGQSGAQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYGLTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ
Protein: Large ribosomal subunit protein uL6m (54S ribosomal protein L6, mitochondrial) (YmL16) (P32904)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL5m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL3m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS2m
Sequence:
MSFIQRRLLSQTLFLRSQVGSLPLYISPEVQVSINALSMPRIIRKGRTSMNISQNITVKGPKGELSVEVPDFLHLDKDEKHGKINVTVQNSEDKHQRSMWGTVRSLINNHIIGVTEGHLAVLRFVGTGYRAQLENDGKFVNVKVGASIKQGLDVPEGIVVKTPAPTSLIIEGCNKQQVLLFAAKLRKFHPPEPYKGKGIYVNDETIKLKDKKIK
Protein: Transmembrane protein 91 (Dispanin subfamily C member 3) (DSPC3) (Synapse differentiation-induced protein 3) (Q8C581)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transmembrane protein 233
Sequence:
MDNSSIQELQQPLLPSITCDLLAPRSEKPELGTPFPETAFAESPRGWQLLLPPLPSVSAGLGEPETPDFEDTLSSDSDSDDDGGDRLSPLLPHDHLGLAVFSVLCCFWPVGIAAFCLAHKTNKAWAKGDVQGAGAASRRAFLLGVLAVGLGLCTYAAALVTLAAYLASRDPP
Protein: Secreted effector protein (A0A0F6AZL3)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Interaction partners:
Sequence:
MPFHIGSGCLPAIISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQAEALECIWTICHPPAGTTREDVVSRFELLRTLAYDGWEENIHSGLHGENYFCILDEGSQEILSVTLDDVGNYTVNCQGYSETHHLTMATEPGVERTDITYNLTSDIDAAAYLEELKQNPIINNKIMNPVGQCESLMTPVSNFMNEKGFDNIRYRGIFIWDKPTEEIPTNHFAVVGNKEGKDYVFDVSAHQFENRGMSNLNGPLILSADEWVCKYRMATRRKLIYYTDFSNSSIAANAYDALPRELESESMAGKVFVTSPRWFNTFKKQKYSLIGKM
Protein: Armadillo repeat-containing protein gudu (Q9VM21)
Organism: Drosophila melanogaster (Fruit fly)
Function: Important for spermatogenesis where it may have a role in sperm individualization.
Interaction partners:
- AT03545p
- Coiled-coil domain containing protein 114
- EF-hand domain-containing protein
- Zinc finger MYND domain-containing protein 10 homolog
- Putative inner dynein arm light chain, axonemal
- Tektin
- Outer dynein arm-docking complex subunit 4
- GEO10781p1
- Coiled-coil domain-containing protein 39
- RE41410p
Sequence:
MIGTSSGTSHNRSRKKKEQCGSCPNRFSKDKRQVAAEDSDTTEVESSTDEEERWKEVARAAEIPADYYNIQKLVKYIKAGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLDVLVNILECSDTKCCLGALKVLSDITLNIDIRKTIVDLDGIPLIVDILNSSMKDLKTMAAETLANVCKVRLARKYVRTCGGIPKLVDLIDIKLSILKTPRDQLSPDDLESLDMTRAGARALFTLADSKHNMEQMRKSGIVPLMAQLLKSCHIDVVIPIMGTVRKCSSEPKFQLAITTEGMIPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRDLVREAGGLEPLVTIIKDKNVRENKPLLRGATGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECDEVLTNVTGAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSMRILEDLDAVRLIWSLLKNPTTRVQAHAAYAICPCVRNANDSAELVRSLVGAMELVVGLLKSKDIMVLSAVCAAIATIAQDQTNLAILTDLKVIYKLADLVQTTDDLLRMNLAAAVAACACFGNNTEELGRLRTVTPIVTYMTSDNPLVHRSTAMALEKLSMDPQNCITMHQSGVVPFLLECIGSTNKELQLAAAGCLRNIRELALRAEEYLLKIDDD
Protein: Unconventional myosin-VI (Unconventional myosin-6) (F1Q6Q6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
Interaction partners:
Sequence:
MDDGKPVWAPHPTDGFQLGRIIDISADSLTIEPLNQRGKNFQAPVDQVFPAEDDVNKHVEDNCSLMYLNEATLLNNVRVRYSKDKIYTFVANILIAVNPYCEIPKLYSPETIKQYQGRSLGTLPPHVYAIADKAYRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICTQGQEERNYHIFYRLCAGAPEDIREKFHLSSPDCFRYLCRGCTRYFSTKDSDKLIPQNRKSPELLKAGPLKDPLLDDHADFNRMSVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEEAGSTSGGCVLKKTCGQSLQFCAELLGLDEEDLRVSLTSRVMLTTAGGTKGTVIKVPLKVEQASSARDALAKAIYSRLFDHVVTRINQCFPFDSSAHFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLVESKVVGILDILDEENRLPQPSDQHFTETVHSKHKDHFRLTVPRKSKLQVHRNVRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLACLVSESKDKFIGELFENSNHSKDTKQKAGKLSFISVGNKFKTQLNILLEKLHSTGSSFVRCVKPNLKMVGHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPAKLTRLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKWLICSRWKKVQWCALSVIKLKNKMLYRAQACVQMQKTVRMWLCRRKHKPRIDGLVKAQNLKKRMEKLNEVVSGLKEGKQEMSKHMQDLDSSIDAHIRKIKSIVMSRMDIDHEHQALVTRSQELLSAMQKKKQEEEEMERLKRIQEEMEKERKRREEEEQKRKREEEERRQKAEMELKRKQEEEERKKREEEERKLQEEMELQLEAEREQETSRQAVLEQERRDRELALRIAQSEAELIPEETPPDAGLRRGPQVSANNAQADVKKYELSKWKYAELRDAINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNVQEEQRAPKAITDYAQQNPVVPAAVPRQHEIVMNRQQRFFRIPFIRPGDQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKHPILLVAGKDDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLRNAIESRQARPTYATAMLQSMLK
Protein: Oxidoreductase, aldo/keto reductase family (A0A0H2UQQ5)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETATIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVDDVDF
Protein: Receptor tyrosine kinase (Q7KA90)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESTTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNLPINEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQEL
Protein: Interferon-gamma receptor alpha chain (A1IMH9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MAWVRMVHISLILVLSQQVDSYVPPPVNVSVICRNFHNVIYWNYSEPSLQPQFNVEMTRKYSGAALVCSNTSLYHCDVSSFTKVIEEGYRFILTAVGQNTNSSEISFTYDDTVYPDLVDVQCSLDFPPVNISAVSDQIIKVQFIHPFHIYKYAIIKNERPDHKEFHYMVVTEDHLKQHSFACSYKQHHVCEAEIPVDGKMDRHCIKMKGKMNNVHVSAHQNICIEGKHGDSGPSYTALYIVIPIVAMVVIAFIVWLIYRKLTSGSFPQPKILASILSHIGSVRSLMLPERAILSEVQTGGSPLLQTPMESLPDETLTVFSTPQEEVLRLPIGLKDQEWSGGEVMLPNEGSGSSLQVTRELGLKVKSNFAELSNYDCSHRLVIEEMSPARSA
Protein: Centrosomal protein 128 (Full-length cDNA 5-PRIME end of clone CS0CAP003YE19 of Thymus of Homo sapiens (human)) (Q86TS1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLG
Protein: von Willebrand factor A domain-related protein (Q8IAL0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKSLKVVLCLGMISACMLVGTYGRMNVVSHNSMKKVGEEGKDEKIISCVVEYVIKGDLSIDDGDFCDSNSICSNNPGLCDNGQVVVPGDYCSNYYDITLVVEESSFVQKDYWLKGTIPFLESMVFNSNVSKDKAHMSVVLFAGKQRVVVPFTDESSQDKNMLLEKINSIDEGIATSSDTLYVNALKYAIENVIFGDGTRKDAPKVAVLFYYGFDYGANKNMIPDVVQTYKEQNVKLIIVGIALGIRDNAYLLADCSIGDENCVNVVFKPWDFVIPAAADVNQKICDKNKS
Protein: Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) (Q9JKV2)
Organism: Mus musculus (Mouse)
Function: Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a role in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62726}. Cell projection, cilium {ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:25243405}. Nucleus {ECO:0000269|PubMed:15988018, ECO:0000269|PubMed:25243405}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24853502}. Note=Also found at the ciliary tip (PubMed:24797473). Predominant nuclear localization has been observed with a N-terminally GFP-tagged construct in transfected COS-7 cells (PubMed:15988018). {ECO:0000269|PubMed:15988018, ECO:0000269|PubMed:24797473}.
Interaction partners:
- DNA replication licensing factor MCM7
- Origin recognition complex subunit 3
- DNA replication licensing factor MCM2
- Cell division control protein 6 homolog
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM6
- DNA replication factor Cdt1
- Origin recognition complex subunit 4
- Origin recognition complex subunit 5
Sequence:
MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGIISKDSGKPQREVQDKTGPPPYIKPAPPAQAPAKAYTLISSRPSQASQPPQHSVHPYKGDVSRTEQLSHVQEGKPSPPFFPSLHNKNLQPKILASLEQKNGEIKPKSRRRWGLISRSTKGSDDWADLDDLDFSPSLTRIDVKNKKRQSDDTLCRFESVLDLKPSESVGTGTTVSTQASSQRRDTPTLQSSAKQHYLKHSRYLPGINIRNGVLPNPGKDFLPSNSWSSSGLSGKSSGTVSVVSKITSVGSGSASSSGLTGSYIPSFLKKEIGSVMQRVQLAPLAAPPPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRIDWSSKYPSRR
Protein: Ecto-NOX disulfide-thiol exchanger 1 (X1WCA2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Ankyrin repeat domain 10a.
- Dleu7
Sequence:
MASAADGIGSLGTEQSHINVPVADPGAWATAMNNLGIVPMGLTGQQLVSDSICIQGFDPNIGIITPINPMMAGISLVPPHPVAAELPVIKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIKEVFDQCGEIIAIRKSKKNFCHIRFIEEFMVDKALYLSGYRMRIGSSTDKKDSGRIHVDFAQARDDLYEWECKQRLLAREERHRRKIHEERLRPPSPPPIMHYSEHEATLLAEKLKDDNKFSEATAVLFTWIDRGEVNRRSANHFYSMIQSANSHVRRLMSEKAQHEEEMELAKEHFKNSLLAILTQFEQITAVFTAATRQKAWDHFSKAQRKNIDIWRKQCEELRNAHSEEIMGIRREEEMEMSDEDSDENPCKKIRLEDSVLSAQSCALREENDSLRWQLDAYRNEVELLKKEQGKMYRTEEDHTHEQQLHFLQQTMQNMQQQLLRLQEELKGKELELEQARDEQRYLEGEVISLREKLLNAMESVDMTNHNSECHEKAVNGTAALYHHREKNNETVIWGPLRSEKEALLLGIISTFLHVHPFGANIEYLWSYIQRLDTKISASELERLMVRLPNMFKQEFSGVGATLEKRWKFCGFEALKSA
Protein: DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) (Q9H9Y6)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
Subcellular location: Nucleus, nucleolus {ECO:0000305|PubMed:34887565, ECO:0000305|PubMed:36271492}. Chromosome {ECO:0000250|UniProtKB:P70700}.
Interaction partners:
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerase I subunit RPA43
- RNA polymerase I-specific transcription initiation factor RRN3
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase I subunit RPA49
- DNA-directed RNA polymerase I subunit RPA1
Sequence:
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQAIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV
Protein: Four domain-type voltage-gated ion channel alpha-1 subunit (Ion transport domain-containing protein) (G5EDM1)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncoordinated protein 79
- Protein unc-80
- NCA Localization Factor
- VWFA domain-containing protein
- Guanylate kinase/L-type calcium channel beta subunit domain-containing protein
- SH3 domain-containing protein
- Voltage-dependent calcium channel unc-36
- Voltage-dependent T-type calcium channel subunit alpha
- Calcium-activated potassium channel slo-1
Sequence:
MTSTTAKLLGLSACRAAALSTTMLTRRKSSIDGTKTERNRRRGESIGGAFTDMINIEPTSIINKSTELLHERFLRDMVRVACLLSMISLCLHTPETIKMWPPLNYIILANDVIVTLIFIGEAAVTINQNGLFDNQNSYLRDRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVYYPWLGALRSARPFIFLRFIRSIVRFKLPKNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLFGRLNYHCVVNGTDPNNVTIADLAIPDTMCSQKGAGGYECPGNMVCMRLQLKPQEEGFYGQFSDFASSLFTVYLAASQEGWVYVLYDCLDSLPSFLAFFYFVTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMWQTREATTDHVYTQKLEKDEDGWKLVEVDKYNRAHSNNSLFLHTIVTSTAFQTVMQLLILANAIFHATFVFYHDESDQIRKIWYYYVEVGFTILFNTEVIIKIYAFGWKAYIARGQHKFDCILCVGSSLNAIWVLYETNIFTYFQVFRIARLIKASPMLEDFVYKIFGPGKKLGGLVIFTGILLIVTSAISLQLFCYVPKLNKFTNFAVAFMSMFQIITQEGWTDVVIEILRACNEQAVPFVAIYFVAYHLLVTLFVLSLFVAVILDNLEMDEELKKVKQLKAREQDTIKTTLPMRLRIFNRFPTAPTMVTMKKVSSEFPLPKIRDSFTRQFADEFVETSDDTIQEIGFKVRSMLSGRGPSKETRITTTIRHVGQLSNKTILTSMLTESNRNRALFSESNQHLASLTRSNTSSKHGKSGALSTNSRSRTRGLASLKGKHMVEGFKENGDLRPEDTARKVEKHGEIDFKALQMKRAHAEITRNRIEEEMRENHPMFDRPLFLVGRESSLRRMCQLIAHSRHSYDQNDGQHRKHSNKYKQFHDFLAIMTYMDWTMVLVTTLSCCSMLWESPWPTTGENLIFNNFYLQIAEYIFVLVMSFELIVKCIANGLFFTPKALVTDVGDILTIFIYITSLMFLIWMPNHIEINSWAQLLMVCRAMRPLRVYALIPHIRRVVVELCRGFREILLVTILLVVLMFIFASFGVQLVGGKLASCNDPMITSRENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVPRVWTNPRNFNFDHIGNAMLALFETLSYKGWNVVRDVLYLRHGAWAVLFIHIYVFIGCMIGLTLFVGVVVANYTENRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPPESAKLRCYLYDLTTSRWFKQLFAVLVVVNSFTLVIPWNVSEEQDRKTFLLCLTVISAICNILFTLECLLKMIAFTLSGFWQSRRNRIDFIITILGINWIVFHFLFQLPAYFAGGITEWKRLTYTYGYLVVILRFFTIAGRKSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGVVLFGMVKYGQAVGKHVNFRNGREALVVLFRSVTGEDWNDIMHDCMRAPPFCNWHPGLSYWQTDCGNYVGAIVYFCSFYLIITYIVLNLLVAIIMENFSLFYSSEEDALLSYADIRNFQLVWNMVDIEQKRSIPVRRVKFLLRLLKGRLEVNDESDGLLFKHMCHEMERLHNGDDVSFHDVLNMLSYRSVDIRKSLQLEELLQREELEYIIEEEVAKHTIRAWLENCLKNIKAKQNNTLGKMSSIGSTFAFPQSQEVLTKGVVLTEASPEEDSLQGDKGSGKKKAQRGNSITEIVAEAQKKSVKRATDKISERRGTLRQMQMGTYDELEEVEEDEDTDGEIRRSSFEYSGVDMIQMSHEKQLEDVKTWWTLCD