wanglab/gogpt-training-data huggingface dataset:
Protein: UTP4 small subunit processome component (H3BSH7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
RSTSGAEPESARARGAGAERGEHREGERGAAGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT
Protein: NACHT and WD repeat domain containing 1 (F8W0U9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQRGKPCRALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDPLKNFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) (Q99JE6)
Organism: Rattus norvegicus (Rat)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8454637}. Membrane {ECO:0000269|PubMed:8454637}. Nucleus {ECO:0000250|UniProtKB:P51432}. Note=And particulate fractions.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Guanine nucleotide-binding protein subunit alpha-15
- Guanine nucleotide-binding protein subunit alpha
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Calmodulin-1
Sequence:
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRLDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNAPEHVLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALICGLNFNRSESIRPDEFSLEIFERFLNKLLLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYEPNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLSAGTPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVAKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEEGLNRGPNVLMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEASRKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTEMCQETPSQQQGSQLSSNPVPNPLDDSPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSSSALSRATNVEDVKEEEKEAARQYREFQNRQVQSLLELREAQADAETERRLEHLKQAQQRLREVVLDAHTTQFKRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLLAGQQQVLQQLVEEEPKLVAQLTQECQEQRERLPQEIRRCLLGETSEGLGDGPLVACASNGHAAGSGGHQSGADSESQEENTQL
Protein: Uncharacterized membrane protein C27F1.10 (Q9C112)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm. Nucleus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized aminotransferase C27F1.05c
- Meiotically up-regulated gene 52 protein
Sequence:
MQLTGSIYPWFTAYALLKSTLMELINSFIPYKSQTGKAPKCLVPYWLSIRLSLLYFKLTEAISFTEKCEKYNISLFDSTFVFGYIVNCFFIIHLNTFLTSQ
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (A0A8I6A0G0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
Sequence:
MCDLGAFITLRRRSSMAKNFPPPSPSSNCSGIFLLSLWDNSLEKFVDNMLLRSSGKLNVGTKKEDGESTAPTARPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGTPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRTHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
Protein: SH3 domain-containing protein (E3W735)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MEPGSGSPLSARAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITEKDKLQRSRSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEYCTLVGNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYADNHPDAVEVLKKKQKELEKVVKSQDREYKELVLGLSEPLRHVERYYNLLQELERIVPANHPDRGDLQRGSAVFRETKDLCETLRKQKEAQLDFLFVSKVDKVVSASERGSILYVGVANVEYKKADAVDRFVALFTKYIMFFEVTKDMTYDIKEKFTVSGFIVRKKEATEISFDRPNTGEFTLTMVSTGGEVERFLVALAKAENVAIITPTTTILRRPSKNANDTMNQSQTQGAETPLVAKPPLHPPGNSDQQYSMMNKRKSSKK
Protein: Stomatin-like protein 1 (SLP-1) (Q8CI66)
Organism: Mus musculus (Mouse)
Function: May play a role in cholesterol transfer to late endosomes (By similarity). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions.
Subcellular location: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:24247984}. Cell membrane {ECO:0000269|PubMed:24247984}; Single-pass type III membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000250|UniProtKB:Q9UBI4}. Membrane raft {ECO:0000250|UniProtKB:Q9UBI4}.
Interaction partners:
- Epimerase family protein SDR39U1
- Protein NYNRIN
Sequence:
MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGSVGPGADAPESWPSCLCHGLVSVLGFLLLLLTFPISGWFALKIVPTYERMIVFRLGRIRNPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMAVKDLNTATRMTAHNAMTKALLRRPLQEIQMEKLKIGDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSLTVPSLDSTLQQLALHLLGGSMNSAVGRVPSPGPDTLEMINEVEPPASLAGAGAEPSPKQPVAEGLLTALQPFLSEALVSQVGACYQFNVILPSGTQSIYFLDLTTGQGRVGHGEPDGIPDVVVEMAEADLQALLSKELRPLGAYMSGRLKVKGDLAVVMKLEAVLKALK
Protein: Gem-associated protein 2 (Gemin2) (Q9VVX0)
Organism: Drosophila melanogaster (Fruit fly)
Function: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18621711, ECO:0000269|PubMed:20452345}. Cytoplasm, U-body {ECO:0000269|PubMed:20452345}.
Interaction partners:
- Survival motor neuron protein
- Probable small nuclear ribonucleoprotein Sm D1
- Probable small nuclear ribonucleoprotein Sm D2
- Gem-associated protein 5
- RNA helicase
- Gem-associated protein 4a
- Small nuclear ribonucleoprotein-associated protein B
- Gem-associated protein 4b
- Small nuclear ribonucleoprotein Sm D3
- Probable U2 small nuclear ribonucleoprotein A'
Sequence:
MQHEPEDQTFQLQALEICEPDSSFDPQKPPESGEEYLMHMFYERKRCPAVVTKRSSKIRNNTGNTTLEMLDNPELPPFKCLLPTPEWRDEQVKSFQAARSQVLVLRKELANNNYDQSGEPPLTSDQEKWKEFCRNQQPLLSTLLHLTQNDLELLLEMLSKWLQDPNTTVDLLHDVWLARWLYATLVCLHLPLEPHVFSTLRYIARTCIHLRNQLKEDEVQRAAPYNLLLTLTVQVFAQNDFKDYI
Protein: Myosin light chain kinase isoform-I (O01651)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSQLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAESRRIPTTRTYTSLLVLPAIRGNSSSSSLAARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKVIWYKACHPIVDSSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRFRVRAENIHGRSAPGQASELVQITNTPQRSTSSDASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLESKWLSQRPDDSLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGGGTSSQMTSLHEEEDDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLELPTKGEAIMRSDFTNTIKMRKKSLEDSAAREKPRSKPQVKPLLCESKLKVSQLKDRFQVSPAPASASASASAANKPPLAYGPFKIAKVASVGRISRTEEPGRSGRGAPSVSGKGKSPQVRSMPSSPLPQRSATPTQLMSQRVREAAERLAQQHTVASAQRHLGNGRGTGNGNGNGNSNSNGNGNGNTAETNRESRARRLINRFNSETQHITS
Protein: Probable sulfate-binding lipoprotein SubI (P71744)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- Sulfate/thiosulfate import ATP-binding protein CysA
- Sulfate transport system permease protein CysT
- Probable sulfate-transport integral membrane protein ABC transporter CysW
- Bifunctional enzyme CysN/CysC
- Sulfate adenylyltransferase subunit 2
- Adenosine 5'-phosphosulfate reductase
- Molybdenum import ATP-binding protein ModC
Sequence:
MLSLTLSEASCIASASRWRHIIPAGVVCALIAGIGVGCHGGPSDVVGRAGPDRAHTSITLVAYAVPEPGWSAVIPAFNASEQGRGVQVITSYGASADQSRGVADGKPADLVNFSVEPDIARLVKAGKVDKDWDADATKGIPFGSVVTFVVRAGNPKNIRDWDDLLRPGIEVITPSPLSSGSAKWNLLAPYAAKSDGGRNNQAGIDFVNTLVNEHVKLRPGSGREATDVFVQGSGDVLISYENEAIATERAGKPVQHVTPPQTFKIENPLAVVATSTHLGAATAFRNFQYTVQAQKLWAQAGFRPVDPAVAADFADLFPVPAKLWTIADLGGWGSVDPQLFDKATGSITKIYLRATG
Protein: Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (Q9R190)
Organism: Mus musculus (Mouse)
Function: May function as a transcriptional coregulator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:11749719}.
Interaction partners:
- Histone deacetylase 1
- Chromodomain-helicase-DNA-binding protein 4
- Histone-binding protein RBBP7
- DNA helicase
- Histone deacetylase 2
- Transcriptional repressor p66 alpha
- Histone-binding protein RBBP4
- Methyl-CpG-binding domain protein 3
- Transcriptional repressor p66-beta
- Metastasis-associated protein MTA1
Sequence:
MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILNQYLDKEDCFFYSLVFDPVQKTLLADQGEIRVGCKFQAEIPDRLAEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLKTPTQLEGAARGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLTQNRGLGGIMVKRSYETMAGAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLMTVRPPVPLPASSHPASTNEPIVLED
Protein: Formin like 1 (K7EK60)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLQVTSDLSL
Protein: DELLA protein 2 (MtDELLA2) (A0A396GMX6)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway (By similarity). Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes (By similarity). Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway (By similarity). Together with DELLA1, required to enable arbuscule development during arbuscular mycorrhizal (AM) symbiosis with AM fungi (e.g. Glomus versiforme) via the regulation of RAM1 which, in turn, regulates various AM genes (e.g. NSP1, NSP2, PT4, LEC5, RAM2, EXO70I, STR and RAD1).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A0A396IUP1}.
Interaction partners:
Sequence:
MKREHKLEHEDMSSGSGKSGVCWEDDGGGMDELLAVVGYKVKSSDMAEVAQKLEQLEQAMMGNNFHDHDESTIAQHLSNDTVHYNPSDISNWLQTMLSNFDPQPNNPSVNSDDNDLNAIPGKAIYAADEFTSRKRVKRNESVTVTTESTTTRPIMVVETQEKGIRLVHSLMACAEAVEQNNLKMAEALVKQIGYLAVSQEGAMRKVATYFAEGLARRIYGVFPQHSVSDSLQIHFYETCPNLKFAHFTANQAILEAFQGKSSVHVIDFSINQGMQWPALMQALALRPGGPPAFRLTGIGPPASDNSDHLQQVGWRLAQFAQTIHVQFEYRGFVANSLADLDASMLELRSPETESVAVNSVFELHKLNARPGALEKVFSVIRQIRPEIVTVVEQEANHNGPAFLDRFTESLHYYSTLFDSLEGSSVEPQDKAMSEVYLGKQICNVVACEGTDRVERHETLNQWRNRFNSAGFSPVHLGSNAFKQASMLLALFAGGDGYKVEENDGCLMLGWHTRPLIATSAWKLAAANSVVVSH
Protein: Enolase-related protein 2 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (P0CX11)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIHEAVELRDGNKSEWMGKGVTKAVSNVNSIIGPALIKSELCVTNQKGIDELMISLDGTSNKSRLGANAILGVSLCVARAAAAQKGITLYKYIAELADARQDPFVIPVPFFNVLNGGAHAGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLKILAKEQYGPSAGNVGDEGGVAPDIDTAEDALDMIVEAINICGYEGRVKVGIDSAPSVFYKDGKYDLNFKEPNSDPSHWLSPAQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTCTNKTRIARAIEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVGLRCGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRFHDGNKL
Protein: At1g17310 (MADS-box protein) (MADS-box transcription factor family protein) (T13M22.2 protein) (Q9LN16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKDLFMEGERETSSMTCLTPKDSVQSPNMLVRQPKKETTTQTPKTTRGRQKIEIKKIEEETKRQVTFSKRRRGLFKKSAELSVLTGAKIAVITFSKCDRIYRFGHVDALIDKYLRKSPVKLEGYSGDNAADEESRRPWWERPVESVPEEELEEYMAALSMLRENIGKKIVAMGNDRTVDMVPAWPINVMGWKPTMDMQKLENLTDGVNRCRVGQNGD
Protein: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155) (Q1ECU6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C.
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B.
- Zgc:154054.
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A.
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
- RNA-binding region-containing protein 3
- Beta-galactoside alpha-2,6-sialyltransferase 1
- E3 ubiquitin-protein ligase UNKL isoform X1
- Heat shock protein 70 family, member 13.
Sequence:
MGSVYLWKLSSQKLGFFLVSFGFIWGMMLLHFTIQQRATHESSAQLRMQILDLSKRYIKALAEENQSVMDGPYVGTMTAYDLKKTLAVLLDNIMQRLSKLESKVDNIMYNGTSANLTNGTGTPGPNPVNPEKVNVADLLNGAQEKCELPSLDGFPHCEGKIKWMKDMWRSDPCYGNYGVDGSTCSFFIYLSEVENWCPRLPWRIKNIGDDLDRKTQLEVRTSFDELYRVMSRREEFRWMMLRIKRMEEPWVSAVRSLANKQNLHHRKRKKILVHLGLLTKESGFKIAENAFSGGPLGELVQWSDLITTLYLLGHDIRISASLAELKEIMKKVMDNKSSCPTKGDKVVELIYIDIVGLAQFKKTLGPSWVHYQCMLRVLDSFGTEPEFNHAHYAQSKGHKTPWGKWNLNPQQFNTMFPHTPDNSFLGFVVEQHLNASDVKHIDDIKRQNQSLVYGKVDNFWKDKKKYLDIIHSYMEVHGTVHGTSTVHLPGYVKNHGILSGRDLQFLLRETKLFVGLSFPYEGPAPLEAIANGCAFLNPRFDPAKSSKNTDFFKGKPTLRELTSQHPYAEVYIGRPHVWTVNIEDPAEVENAIKAILSQKIEPYLPYEFTCEGMLQRVNAFIENQDFCHGQVMWPPLSSMQVRLAPAGKSCKQVCQEEQLICEPSFFQHLNKDKDLARYGVECKTVDSANDIVVPAFSESSRHCVFQSDLLLFSCAGAHQTLTRICPCRDYMKGQVALCKDCL
Protein: Heat shock protein DnaJ, putative (Q57V04)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MFAFSDHMDDVFNAFFSGGDMFSGGDMFSGGGGRGRRRQPKDTVHGLPVTLKDLYNGRSIEIPHTRTTPCVGCDGRGAKSRKNVTCTACRGAGRRMLARQMGMMIQQVTVPCDACGGEGRRMDPRDICPVCDGRRVNQVESSLTVVVEPGMEHREQIVFHGEGSYQPAADAAGDIVIVLEQMKDDRFEREGDDLLYTHTISLAESLCGFQLVLTHLDGRQLVVRRERGEITRPGERKVVLGEGMPIRGRKGKFGDLVIKFAVSFPERIEEAQVEILRQALPAPRSVDLSHCDMAQECYVSRKELDHLRQELENDVEEQETTSVGCTAQ
Protein: CG5669 (Q2XXX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
ASAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQLITIPGTNIQIPVTNLIQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQTANGQTIYQTVHVPIQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIQGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRVACTCPNCTDGEKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAATVAGSTVTPGGATIVQLPTVEASGGGDSFGDDEDDEEDDELTEEDDEDEELDEDDMDDCEDEEDDEDPELDSGDEVKMTIAVSEP
Protein: Solute carrier family 35 member B1 (ATP/ADP exchanger ER) (AXER) (Endoplasmic reticulum ATP/ADP translocase) (UDP-galactose transporter-related protein 1) (UGTrel1) (P78383)
Organism: Homo sapiens (Human)
Function: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction. Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER. Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30154480}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nucleotide sugar transporter SLC35D1
- UDP-galactose translocator
- Solute carrier family 35 member D3
- Periodic tryptophan protein 2 homolog
- Uncharacterized protein.
- Nucleotide sugar transporter SLC35D2
Sequence:
MASSSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQCVINAVFAKILIQFFDTARVDRTRSWLYAACSISYLGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGMGILFTGELWEFLSFAERYPAIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISPMQWVGTVLVFLGLGLDAKFGKGAKKTSH
Protein: Uncharacterized protein C1F3.03 (Q10408)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein transport protein sec9
- Syntaxin-like protein psy1
- Exocyst complex component sec8
Sequence:
MSFFKKKLSKGKEILSKSNLKTHTSSNASLSIDDLNRFGFSLNPVLWCLDHQQGLLAIVSSTNRIYIYGKQHVQSVIVPDCSTIVHIALCAAYLIVIDSRNTVLSYPLMKHRDLSKPAATYFLKQKVTCTVTDPTIDWVFFGMSDGSVVPWDVTRHCLGKFKVPNLYVPRHEEWRMMGYSYAPVPGKLSPVVSVQIHPKDLGVILIAYPDGVVLYSIRTDEVIRFYELEYAPGSTAAVLSPHNYRRPIVKGIEWSPWGDHFVSYYTDSTFAFWDVDQEYPVQVRNFVDSNIHTYTPMQRNPPKTELEPIRSMRWCCCEDPTVSFILMLGGLPKEAPVKGISLFSYRNLPAKKDVETFAEFFANPNSQRFFPFIDIPPVRDMLVIPSSSPHYNGSHNPKNLLLLSEDNSLSLLDISTGNISNMSLSIPPSLCFLASDFRVIAFQTVTKKVWNQIEDTISVNSHYSCLFGGSPSPGYLKKLDERNLLITSTGLSLSIWDISQGFMNPSLCVNLDFSSVMRKHLTPSAFITTASFSTYNPEFSCADSFGRVIVCKRKNHKENLPAQLANGIYRLDDTLVLEGTLHAQYYIDLKRGRVTLNQMSNIGFVCIGYQDGGITIIDMRGPHILCNTSISELGLERRGKPDPDFLTSAEFVVMNPKGSPSSIYVVTGTYRGMTLLFRIDPSSSGRFSAYFESSRQLDIKNIYKICSLTQDGQIATATGSSLQSVGYPLPQEVFLVYIGDSGISVFNKINNQVGNLDWRKPVCCRAALVLSTVSKHMGSVVCVNSDLSVNWYSLPNLREERKMQLPLDIDKNRLKEGDILGNGDYIFPTLGAHELAFGCVLGSGRTLANLAPMMLITHNASHVPPRPSKSLWNWLLGEQSTSAEELDILLGGENRAESKVHTLETPKVISARPAESVKQPLTPVPSMTSQSAQSYIPPRRQQQQKGFFAQINDHLAQRGNMLGGIENTMDDLEEMSAEWANEIKDSLAGTKKDLILSGLKSYIP