wanglab/gogpt-training-data huggingface dataset:
Protein: Protein IRS1 (HQRF1) (P09715)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Inhibits the establishment of the antiviral state in the infected cell. Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR. May also participate in viral DNA replication by interacting with the DNA polymerase accessory protein and the lytic origin of replication, oriLyt.
Subcellular location: Virion {ECO:0000269|PubMed:8995674}. Host cytoplasm {ECO:0000269|PubMed:8995674}. Host nucleus {ECO:0000269|PubMed:8995674}. Note=Isoform IRS1-263 is predominantly nuclear.
Interaction partners:
Sequence:
MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGAPSTAGTGASAAATTTPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALTELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTVGDKAGHPEGLCAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPGRRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTAAGTTSPPAASGTETEAAGGDAPCAIAGAVGSAVPVPPQPYGAAGGGAICVPNADAHAVVGADAAAAAAPTVMVGSTAMAGPAASGTVPRAMLVVLLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGALALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQWEFMFREQRGDPINDPLAFRLSDARTLGLDLTTVMTERQSQLPEKYIGFYQIRKPPWLMEQPPPPSRQTKPDAATMPPPLSAQASVSYALRYDDESWRPLSTVDDHKAWLDLDESHWVLGDSRPDDIKQRRLLKATQRRGAEIDRPMPVVPEECYDQRFTTEGHQVIPLCASEPEDDDEDPTYDELPSRPPQKHKPPDKPPRLCKTGPGPPPLPPKQRHGSTDGKVSAPRQSEHHKRQTRPPRPPPPKFGDRTAAHLSQNMRDMYLDMCTSSGHRPRPPAPPRPKKCQTHAPHHVHH
Protein: HTH-type transcriptional regulator AcrR (Potential acrAB operon repressor) (P0ACS9)
Organism: Escherichia coli (strain K12)
Function: Potential regulator protein for the acrAB genes.
Interaction partners:
- Multidrug efflux pump subunit AcrA
- Multiple antibiotic resistance protein MarA
- Redox-sensitive transcriptional activator SoxR
- Regulatory protein SoxS
- Multiple antibiotic resistance protein MarR
- Outer membrane protein TolC
- Right origin-binding protein
- Small ribosomal subunit protein uS4
- DNA gyrase subunit A
- DNA topoisomerase 4 subunit A
Sequence:
MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE
Protein: Guanylate cyclase (EC 4.6.1.2) (Q9VU79)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MFAHPCPAPAGNYHSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTLSCQSIEIVGGQHNKRRPSSYPTANTPLLMNHVEV
Protein: Caudal type homeo box 2 (Q9ESV7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Eomesodermin
- ETS-related transcription factor Elf-5
- Keratin, type I cytoskeletal 20
- Transcription factor GATA-6
- Transcription factor GATA-4
Sequence:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQPSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPAPPPPQPSQPQSGALRSVPEPLSPVTSLQGSVPGSVPGVLGPAGGVLNSTVTQ
Protein: Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1) (P55002)
Organism: Mus musculus (Mouse)
Function: Component of the elastin-associated microfibrils.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Fibrillin-1
- Elastin
- Decorin
- Microfibrillar-associated protein 5
- Fibrillin-2
- Microfibril-associated glycoprotein 4
- Lysyl oxidase homolog 1
- Fibulin-5
- Biglycan
- EGF-containing fibulin-like extracellular matrix protein 2
Sequence:
MRAACLFLLFMPGLLAQGQYDLDPLPPFPDHVQYNHYGDQIDNADYYDYQEVSPRTPEEQFQSQQQVQQEVIPAPTPEPAAAGDLETEPTEPGPLDCREEQYPCTRLYSIHKPCKQCLNEVCFYSLRRVYVVNKEICVRTVCAHEELLRADLCRDKFSKCGVMAVSGLCQSVAASCARSCGGC
Protein: ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) (P43268)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. May play a role in keratinocyte differentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Nuclear receptor coactivator 3
- E3 ubiquitin-protein ligase COP1
- RNA-binding protein EWS
- Transmembrane protease serine 2
- Solute carrier family 45 member 3
- CD99 antigen
- Glial cell line-derived neurotrophic factor
- Eppin
Sequence:
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAYLPELAGPAQPFGPKGGYSY
Protein: Dynein associated protein domain-containing protein (E2JKY8)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MTESGTELPKESVLSRAKKIDDTGPAAPMSPLSTTAAARPRTTSVSSSAQESSTEIEYLRNQVKELTEKLEAARVKRKEDHTKVMELDRVSFELRSSEEVRSRLIQKITELEKQIGDERIAKEQLQAWQDENKVLLSDHQDTMEMATIEKELAEERADSLQNDVLTLTEKLESMETELEILKEEMANGGGAAQVGNSVQMKQIEIQNDKLKDALIKLRDLNAQATLDRQKAVDEAERLKTENSELIRVAENLKRQTEIAESKIAGFQEQIDAAMGAEAMVTQLTDKNFNMEERIMQLEETIEDMEEARDLDEQLAEVQKQQVKDLMKEIEQLKIHIHELNGRIRDEQKHAVDLSQTILKFRERMANLNSQIQDQKDQVLSLEEQLHGHISVDNDRASMVNQLQISANRNFAEDVERQVNAIEVEFARRQAGYLKAFLPDNFSRVGGENDSILLVVMLPRLAAKTKLFASLAAQCFPQVPGGMRREHVTKSHKGEQWAHVARVNYLANSINAALGKLESAIGETTVEVLIKLTETYGEMSTHEKTVDQYLELLKKSRFDENTSLDSFVRPLVYFQNMFSLHIGGDGFNAAHWVSEICASLSAGLAYCRVNTQRISYFLQESITAGEVYNMLQTLNDEFAACESVILKAYRLLPGNVSGSEQKILKLESEFTEDLLNSVVQLDKMVSILQEVCANGALSFGGISETEGFDEKRVKEMINAVLGKQDGYIAIDKTFDPIRALIKSLRDSLEKVNSTLESAKMEHSAPEKKSFPPLLDRAHHRKQAAQEAEGLRWQMEKKDNEMLELRKQMKARIEDVSNYKLRLDMAESRLNSTDKAEGDKVKHLEEKINQMVADHRRKQIEYDESMDALQREMKEVESDNLELKQRANKISKEALWKNIQSMETRSSGSPSVPMSTSIDEGGASRGEVVFLENQLNKQTNARKRAELEVRKLKGELAQAGSKRFSAVPGLISGPITLESQTRQDLLLKLIDNLHDESLRLRREEVNHQAYVPSNPKISTEKMVEEMEIFNVKREQFFDKLNSVNRRLRRVWFDAWGEEYPFEIAAKSRPIVAVPEPKKFEEISAKWGIVW
Protein: At1g10140 (F14N23.2) (Q9SY56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- WEB family protein At5g55860
- WEB family protein At5g16730
- At5g06430
- Amino acid transporter AVT6D
- SNF1-related protein kinase regulatory subunit beta-2
- Non-specific lipid transfer protein GPI-anchored 13
- TATA-box-binding protein 2
- Protection of telomeres protein 1b
- Serine/threonine-protein kinase GRIK1
- Sucrose nonfermenting 4-like protein
Sequence:
MKQNQSKFLRIISTPLRALGKARDFYVRSITGCAARTQYSSSASVSAPFPRSRSSSSAAFSSSASSRRTTDFGIDEDYSELVRAASVRSLGHKNEIDMLIQEKLQQQKQQKQGGLPKSSSAGMARIEEEEETEEGSVNPKVKKTKKVSDLLYPRSKSYAVTTSTPIL
Protein: Cytochrome c oxidase subunit NDUFA4 (F7FN80)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MDPRKELIPLFVFIGAGGTGAALYVMRLALFNPDVSWDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF
Protein: Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) (Q9ZPW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating the ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several other aspects of development. Involved in the control of endoreduplication.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cell division cycle protein 27 homolog A
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 7
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 6
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 27 homolog B
Sequence:
MATESSESEEEGKISGGNYKLIIDDDLREMGKNAAWSVSSCKPGNGVTTLRDDNLETYWQSDGLQPHLINIQFQKKVKLQLVVLYVDFKLDESYTPSKISIRAGDGFHNLKEIKSVELVKPTGWVCLSLSGTDPRETFVNTFMLQIAILSNHLNGRDTHIRQIKVYGPRPNPIPHQPFQFTSMEFLTYSTLR
Protein: Fimbrin (ABP67) (P32599)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity.
Interaction partners:
- Actin
- Actin-binding protein
- Transgelin
- F-actin-capping protein subunit beta
- Cofilin
- Proline-rich protein LAS17
- Actin cytoskeleton-regulatory complex protein SLA1
- Protein SLA2
- Tropomyosin-1
- Coronin-like protein
Sequence:
MNIVKLQRKFPILTQEDLFSTIEKFRAIDLDDKGWVEKQQALEAVSKDGDATYDEARETLKHVGVDASGRVELDDYVGLVAKLRESKTGAAPQTTFNVAPNSTPIVSTAATGLQHKGKGTQAKIIVAGSQTGTTHTINEEERREFTKHINSVLAGDQDIGDLLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKKGKELNNFQASENANIVINSAKAIGCVVVNVHSEDIIEGREHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEDDETLEQFLRLPPEQILLRWFNYHLKQANWNRRVTNFSKDVSDGENYTILLNQLDPALCSKAPLQTTDLMERAEQVLQNAEKLDCRKYLTPSSLVAGNPKLNLAFVAHLFNTHPGLEPIQEEEKPEIEEFDAEGEREARVFTLWLNSLDVDPPVISLFDDLKDGLILLQAYEKVMPGAVDFKHVNKRPASGAEISRFKALENTNYAVDLGRAKGFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNISITMKTLSSSGRDMSDSQILKWAQDQVTKGGKNSTIRSFKDQALSNAHFLLDVLNGIAPGYVDYDLVTPGNTEEERYANARLAISIARKLGALIWLVPEDINEVRARLIITFIASLMTLNK
Protein: Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Protein tilB homolog) (A0A1L8G016)
Organism: Xenopus laevis (African clawed frog)
Function: Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86X45}. Cell projection, cilium {ECO:0000250|UniProtKB:Q86X45}. Dynein axonemal particle {ECO:0000269|PubMed:33263282}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q86X45}. Note=Localized to cytoplasmic puncta in ciliated cells. In the semicircular canal, localized to kinocilia (By similarity). {ECO:0000250|UniProtKB:B3DH20}.
Interaction partners:
Sequence:
MPTISEDLIRRRAEHNNCEIFSLEEISLHQQDLERIEHIDKWCRELKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCESLQKLDLTVNFVGELSSINSLQENLHLRELYLVGNPCAEYEGYRQYVVATLPQLKWLDGKEIERSERIQALQDYPQVQGRMKEQQEAYLRKRAAEREEARSKLQGKQKESRKTQEKKPGFDRRWYTDINNTIPDPVEKPDPTEQNGDETALRKAEEEEEKEFWSQPSQYTPESRLETHRYLEEKRKSKESSSEGELKKKPPRTLITAEGRVLNVNESKLDFSLVDDEENNQFVLDLAIYRHLDTSLVDVDVQPSYIKVLVKEKPFQLVLPAEVKPDSSSAKRSQTTGHLVVTMPKAIGVIQTKRAKSPVVEEQTRKNPPKCSKTFEKLEVDPKACSVPDFANIVQEKKTQAQGPLQFHKNKVKDTEDSEDFIDNTDVPPLM
Protein: Dof zinc finger protein DOF3.2 (AtDOF3.2) (Protein PHLOEM EARLY DOF6) (Q9M1E6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that negatively affects seed germination and opposes TCP14 function in the regulation of a specific set of abscisic acid-related genes. The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression that promotes radial growth of protophloem sieve elements.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00071}.
Interaction partners:
- Transcription factor TCP14
- DELLA protein RGL2
- GATA transcription factor 12
Sequence:
MDYSSMHQNVMGVSSCSTQDYQNQKKPLSATRPAPPEQSLRCPRCDSTNTKFCYYNNYSLSQPRYFCKSCRRYWTKGGILRNIPIGGAYRKHKRSSSATKSLRTTPEPTMTHDGKSFPTASFGYNNNNISNEQMELGLAYALLNKQPLGVSSHLGFGSSQSPMAMDGVYGTTSHQMENTGYAFGNGGGGMEQMATSDPNRVLWGFPWQMNMGGGSGHGHGHVDQIDSGREIWSSTVNYINTGALL
Protein: Acetylcholine receptor delta subunit (Q6S3H8)
Organism: Torpedo marmorata (Marbled electric ray)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTLSNLISLKETDETLTTNVWMDHAWYDHRLTWNASEYSDISILRLRPELIWIPDIVLQNNNDGQYNVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYNANEISMDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYGDKFPNGTNYQDVTFYLIIRRKPLFYVINFITPCVLISFLAALAFYLPAESGEKMSTAICVLLAQAVFLLLTSQRLPETALAVPLIGKYLMFIMSLVTGVVVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILHMSRVDEIEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPRIGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMFIITPVMVLGTIFIFVMGNFNRPPAKPFEGDPFDYSSDHPRCA
Protein: Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4) (D4A055)
Organism: Rattus norvegicus (Rat)
Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Interaction partners:
- Voltage-dependent calcium channel subunit alpha-2/delta-2
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Oxytocin receptor
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Calcium voltage-gated channel auxiliary subunit alpha2delta 4
- Voltage-dependent T-type calcium channel subunit alpha-1H
Sequence:
MSSSYAKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTTTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTSSSTPMTPLLGRNVGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGCSHDSRHRL
Protein: Paired box 7a (Paired box gene 7) (Paired box protein Pax-7a isoform PAX7C) (Transcription factor PAX7C) (O57418)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Myogenic factor.
- Myogenin.
- Myoblast determination protein 1 homolog
- Myogenic factor 6
- Sonic hedgehog protein
- Transcription factor SOX-10
- Forkhead box protein D3
- Homeobox protein six1b
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Odd-paired-like)
Sequence:
MATLPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPSGEASSVSSISRVLRARFGKKDDDDECDKKDEDGEKKTKHSIDGILGDKGNRTDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTLPTYQLPESTYPSTTLSQDGSSTLHRPQPLPPSSMHQGGLSADSGSAYGLSSNRHTFSSYSETFMSPTASSNHMNPVSNGLSPQVMSILSNPSAVPSQPQHDFSISPLHGGLEASNPISASCSQRSDPIKSVDSLASTQSYCPPTYSATSYSVDPVTAGYQYSQYGQTAVDYLAKNVSLSTQRRMKLGDHSAVLGLLQVETGQAY
Protein: HEAT repeat-containing protein 5B (Q8C547)
Organism: Mus musculus (Mouse)
Function: Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9P2D3}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9P2D3}. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin. {ECO:0000250|UniProtKB:Q9P2D3}.
Interaction partners:
Sequence:
MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTYTVFQTLDKCNDIIRSKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLTGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENVATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVDAVYSRRCVSFMLRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSSENKSGTADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDAIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEASFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNAATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNAGDKEISGGNVNPFTPGVSSRSDVHCRHQGVNITDTGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSAATLLSSGKDEESEKKDEMDDDAMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENSDQAHFDLALARSAKLRNPKNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDTVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAMNNPDDDDDDYGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFISQESTEATTVSGVQKRSPAVSLNQVPGAMASAKPLPEVNKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLGSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSIQLLVTGVVQQIVRAAQDYLQEKRNALNEEDMEKESCPTLGEGGDTGGLIPGKSLVFATMELLMFILVRHMPHLSTKMLDSPSHTAMKTQLSEESARLVAATVAILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTTLIRSTLACILEYSQPDDCMPAPDEVSTLTAIALFLWSASSEIIGVQSLQNGCMNRFKSALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPLVVGKLKAVERHRPASSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSISKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKARLETAVRASQASKAKAAARQPAPTTHSTPTIKLKTSFF
Protein: Cyclin-H (MO15-associated protein) (p34) (p37) (P51946)
Organism: Homo sapiens (Human)
Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 3
- Cyclin-dependent kinase 7
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 1
- CDK-activating kinase assembly factor MAT1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 2
- Cyclin-dependent kinase 2
- General transcription factor IIH subunit 5
Sequence:
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL
Protein: Retinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (Short chain dehydrogenase/reductase family 9C member 5) (Q92781)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11675386}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:11675386}.
Interaction partners:
- Retinaldehyde-binding protein 1
- Retinoid isomerohydrolase
- Lecithin retinol acyltransferase
- Retinaldehyde dehydrogenase 3
- Retinol dehydrogenase 10
- Aldehyde dehydrogenase 1A1
- Retinal dehydrogenase 2
- Retinol dehydrogenase 11
- Retinol dehydrogenase 12
- Diacylglycerol O-acyltransferase 1
Sequence:
MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAVY
Protein: Empty spiracles homeobox 3 (Emx1 homeoprotein) (Q90263)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MFQHNKKCFTIESLVGKDSNSSNAAADEPIRPTALRFTESIHPSPFGSCFQNSGRTLYSSSPEMMFTDPSTHSTNSGLSLRHLQIPTQPFFSPHQRDTLNFYPWVLRNRYLGHRFQGDDSSPENLLLHGPFSRKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLANGLCLTETQVKVWFQNRRTKHKRQKLEEESPDPQQKRKGSQHVSRWRVATQQGSPEDIDVISED
Protein: Transcriptional regulatory protein MoaR1 (Molybdopterin biosynthesis positive regulator) (O05797)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Acts as a positive transcriptional regulator of the molybdopterin biosynthesis moa1 locus, promoting the expression of the moaA1B1C1D1 genes. Binds directly to the moaA1 promoter.
Interaction partners:
- Uncharacterized protein Rv0894
- GTP 3',8-cyclase 1
- Putative pterin-4-alpha-carbinolamine dehydratase
- Possible transcriptional regulatory protein
- Transcriptional regulatory protein
- Possible transcriptional regulatory protein
- Molybdopterin synthase sulfur carrier subunit
- site-specific DNA-methyltransferase
- Cyclic pyranopterin monophosphate synthase 1
- Possible transcriptional regulatory protein
Sequence:
MGQRPFSPNHRSGVLNATTAGAVQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQVVAADALVQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDRQQCDLDRFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALTEDELLVHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDAYHRLKSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEELTESDKDLLPIGLA