Protein: Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger homolog) (Monocytic leukemia zinc finger protein) (Q8BZ21)
Organism: Mus musculus (Mouse)
Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92794}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92794}. Nucleus, PML body {ECO:0000250|UniProtKB:Q92794}. Note=Recruited into PML body after DNA damage. {ECO:0000250|UniProtKB:Q92794}.
Interaction partners:
- Peregrin
- Histone acetyltransferase KAT6B
- Inhibitor of growth protein 5
- Nuclear receptor coactivator 2
- Bromodomain-containing 1.
- Chromatin modification-related protein MEAF6
- Bromodomain and PHD finger-containing protein 3
- Histone acetyltransferase p300
- Histone H3.2
- Histone H3.1
Sequence:
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRRTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDTKQSVDWNKLLKRAFEGLAETGGSTLKSIERFLKSQKDVSAACGGSAAPGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAASAEGKEGCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKQPEELVSCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYANPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLERIDGLDFCRDSNAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKKGNRKSSTSDWPTDNQDGWESKQENEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEDEDEEADEGEKEEPQGQERELETRVKVGKSVSREKKDQESSSLIETDKKPEVKELASSSRLSKQALPRDSLPANSQPPRRGRCGRKNRKTQERFGDKDSKMLVDETLSASQEQYGDCEEKSETSQERFTEMEEQLAAPQVQADGKPDIPKGRFSESVELWRGQLKKSPETLKCRLPEGNDRLPCCYTDGDRAFFRGFSESSEEEEEPESPRSNSPPILTKPTLKRKKPILHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEMEEEEEEEEEESELFPRGYFHCLSSQDILRCQSSSKRPSKEEEEEEEESDDADDTPVLKPVSLLRKCDVNSASLEPDTSTPMKKKKGWPKGKSRKPIHWKKRPGRKPGFKLNQEIIAASAQECIVEPVVPIKPGRKPRTQENEEIVEVKEDLLEERKEEMHTEPDEEAEEEEDTTSSDIRAMSPLDSSNSPEAEPKEPEPEEEDEKPSDDQRQSEEEPQELEEQEQEEEDEVTTEANQNEDHDADDEDEGHLDSLKTKEPEEQPAREDDKEEPGIQGSFLAANMQDSRENTKDKDEAEPDSEEDQPSHEASVVSETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSVRSVNSPSMPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGSSICGNNSSQSSCSYGGLSSSSSLTQNSCVVTQQMANMGNSCSMLQQNTVQPAANCNIKSPQTCVVERPPSNQQPPPPPPPPPPPQQPQPPPQQQAAPQPPPPQPQQQQQQQQQPPPPQQQPQPPPPQQQPPLSQCSMNNSFTAAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR