wanglab/gogpt-training-data huggingface dataset:
Protein: Fibroblast growth factor receptor (EC 2.7.10.1) (F1LN06)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MGLPSTWRYGTGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYDPCLPQYPHINGSVKT
Protein: Derlin (Q9VEU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}.
Interaction partners:
- HMG-coA reductase degradation 3, isoform A
- E3 ubiquitin-protein ligase HRD1
- Endoplasmic reticulum lectin 1
- Nuclear protein localization protein 4 homolog
- Derlin-1
- Ubiquitin fusion degradation protein 1 homolog
- Transitional endoplasmic reticulum ATPase TER94
- EG:65F1.1 protein
- Argus, isoform A
- Endoplasmic reticulum chaperone BiP
Sequence:
MNALRQFYLEIPVVTRAYTTVCVLTTLAVHLDLVSPLQLYFNPTLIVRKFQIWRLATTFLYFGTIGISFFFNMVFTYRYCRMLEDGSFRGRSSDFVMMFIFGGVLMTFFGIFVNLLFLGQAFTLMLVYVWSRRNPLVPMNFFGVLNFQAPYLPWVLLCCSMILGNTVWVDVIGMGVGHIYYVLEDVYPTLSNGYRLIKTPYFLKRLFNEHIERNFQAAAEDRPGGFPWGGEGQPLLPEEIAADGQDEEPANRAAPVAAAPQ
Protein: (+)-alpha pinene synthase 1, chloroplastic (EC 4.2.3.121) (Terpene synthase (+)alphapin1) (PcTPS-(+)alphapin1) (R9QMW2)
Organism: Pinus contorta (Shore pine) (Lodgepole pine)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (+)-alpha-pinene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALVSAVPLNSKLCLCRTLFGFSHELKAIHSTVPNLGMCRGGKSIAPSMSMSSTTSVSNEDGVPRRIAGHHSNLWDDDSIASLSTSYEAPSYRERADRVIGEVKNIFDLMSVEDGVFTSPLSDLHHRLWMVDSVERLGIDRHFKHEINSALDHVYSYWTEKGIGRGRESGVTDLNSTALGLRTLRLHGYTVSSHVLDHFKNEKGQFTWSAIQTEGEIRDVLNLFRASLIAFPGEKIMEAAEIFSTMYLKDALQKIPPSGLSQEIEYLLEFGWHTNLPRMETRMYIDVFGEDTTFETPYLIREKLLELAKLEFNIFHSLVKRELQSLTRWWKDYGFPEITFSRHRHVEYYTLAACIANDPKHSAFRLGFGKISHMITILDDIYDTFGTMEELELLTAAFKRWDPSSIECLPDYMKGVYMAVYDNINEMAREAQKIQGWDTVSYARKSWEAFIGAYIQEAKWISSGYLPTFDEYLENGKVSFGSRITTLEPMLTLGFPLPPRILQEIDFPSKFNDLTCAILRLKGDTQCYKADRARGEEASAVSCYMKDHPGITEEDAVNQVNAMVDNLTKELNWELLRPDSGVPISYKKVAFDICRVFHYGYKYRDGFSVASVEIKNLVTRTVVETVPL
Protein: Uncharacterized protein (Q38DN7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRQPFPFVARQQYLENGYAILPNALSPSLVGPLREALIASTVARSRYFIDMPDIESMLKSKGKLSDPLYTNVMARLRKRKHILRQYRAEKRQRRRLAEVAAKVLNGRKKEDLSGEELWKLSEALTKEVAKMSGRGCQATIFNDPQMLRAINEYRCNVWMTNKDLQHIVRDRSFAELIGGVATNVGGVDRPVLFSDAPMLREPYGSPFGYHCTAPTIGVKTNSGRTSCVSLLVFTHQPDSQTMPLFVLKGSHRFVKEQYITRISPGDLWMPFIPMETHIPEQLKRFNFDSSVVGVPIEGGDAIGPGTIIAVDPHLMIGMGCNASPSRVVVYRMNVVSEDATPFMGAPSWIVGWRSLRSEVSFSAPVVFPPLHQVTAATS
Protein: Protein IDA-LIKE 4 (Q6DUW6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in floral abscission.
Subcellular location: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Precursor of CEP15
- Precursor of CEP8
- Precursor of CEP14
- Precursor of CEP4
- Precursor of CEP6
- Precursor of CEP7
- Protein IDA-LIKE 1
- Precursor of CEP13
- Protein IDA-LIKE 5
- Precursor of CEP11
Sequence:
MYPTRPHYWRRRLSINRPQAFLLLILCLFFIHHCDASRFSSSSVFYRNPNYDHSNNTVRRGHFLGFLPRHLPVPASAPSRKHNDIGIQALLSP
Protein: Proline-rich protein 13 (Taxane-resistance protein) (Q9NZ81)
Organism: Homo sapiens (Human)
Function: Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16847352}.
Interaction partners:
- Leukocyte surface antigen CD47
Sequence:
MWNPNAGQPGPNPYPPNIGCPGGSNPAHPPPINPPFPPGPCPPPPGAPHGNPAFPPGGPPHPVPQPGYPGCQPLGPYPPPYPPPAPGIPPVNPLAPGMVGPAVIVDKKMQKKMKKAHKKMHKHQKHHKYHKHGKHSSSSSSSSSSDSD
Protein: Peroxidase 33 (Atperox P33) (EC 1.11.1.7) (ATPCa) (Neutral peroxidase C) (PERC) (P24101)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000305}. Vacuole {ECO:0000305}. Note=Carboxy-terminal extension appears to target the protein to vacuoles.
Interaction partners:
- rhamnogalacturonan endolyase
- Berberine bridge enzyme-like 9
- DEAD-box ATP-dependent RNA helicase 30
- Berberine bridge enzyme-like 23
- Peroxisomal membrane protein PMP22
Sequence:
MQFSSSSITSFTWTVLITVGCLMLCASFSDAQLTPTFYDTSCPTVTNIVRDTIVNELRSDPRIAGSILRLHFHDCFVNGCDASILLDNTTSFRTEKDALGNANSARGFPVIDRMKAAVERACPRTVSCADMLTIAAQQSVTLAGGPSWKVPLGRRDSLQAFLDLANANLPAPFFTLPQLKANFKNVGLDRPSDLVALSGAHTFGKNQCRFIMDRLYNFSNTGLPDPTLNTTYLQTLRGQCPRNGNQSVLVDFDLRTPLVFDNKYYVNLKEQKGLIQSDQELFSSPNATDTIPLVRAYADGTQTFFNAFVEAMNRMGNITPTTGTQGQIRLNCRVVNSNSLLHDVVDIVDFVSSM
Protein: NHS actin remodeling regulator (Nance-Horan syndrome (Human)) (B9EJX2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPFAKRIVEPQWLCRQRRPAPGPDEDTSGGSVEPPPPLQPPGRREEAEAPEPEEPPRVPPAPLPLPPLPPSLPAPAEQDQQPPSEAREAGEESVAGVSEAASAPGETSEASAEAVLLMLDLCAVSNAALARVLRQLSDVARHACSLFQELESDIQLTHRRVWALQGKLGSVQRVLSTLDPKQEAVPVSNLDIESKLSVYYRAPWHQQRNIFLPATRPPCVEELHRHARQSLQALRREHRSRSDRREQRAAAPLPIAAPPLPAYPPAHSQRRREAKDRHFLTSHSPEDEDTDAMLGQRPKNPIHNVPSTLDKQTNWNKALPLPTPEEKMKQDAQVISSCIIPINVTGVGFDREASIRCSLVHSQSVLQRRRKLRRRKTISGIPRRVQQEIDSDESPVARERNVIVHTNPDPSNTVNRRSGTRDSECQTEDILIAAPSRRRIRAQRGQSIAASLSHSAGNISALADKGDTMFTPVVSSRTRSRSLPREGNRGGDAEPKVGAKPSAFEEGERFVGDHERTPNDCSEAPSSPSTQEHQPALGLACSQHLHSPQQKLSERGRSRLSRMAADSGSCDISSNSDTFGSPVHCISTASVLLSSHMDQKEDHQSSSGNWSGSSSTCPSQTSETIPPAASPPLTGSSHCDSELSLNTAPNANEDASVFVTEQYNDHLDKVRGHRTNSFTSTVADLLDDPNNSNTSDSEWNYLHHHHDASCRQDFSPERPKADSLGCPSFTSMGTYDSFLEKSPSDKADTSSHFSVDTEGYYTSMHFDCGLKGNKTYVCHYAGLGPENGQGVGVPPALPDCAWQEYLDHRRQGRPSISFRKPKAKPTPPKRSSSLRKSDGNADISEKKEPKISSGQHLPHSSREMKLPLDFSNTPSRVENANLPAKLDSSWINQSEHAIKEPQLDTPDISPFKDEGAESTHYADLWLLNDLKTNDPYRSLSNSSTATGTTVIECIKSPESSESQTSQSESRATTPSLPSVDNEYKLASPEKLAGLASPSSGYSSQSETPTSSFPTAFFSGPLSPGGSKRKPKVPERKSSLQQPSLKDGALSLSKDFELPIIPPSHLDLSALHVLNKPFHHRHPLHVFTHKQNTVGDMPRSNPAPSLAITPTVLKSVNLRSISKSEEVRQKEGNNTDLPYLEENAATAASVASLSPSKARPHTAKKSISRQYSAEDTLLPFLDSSVAEMGPEKHLEKNPNFDGKSHGDPETATSASSNLPDSNVMKEQIQMESELISENILSKNCGFSTGFQRVSASRPSDLGSKMIQYGASPDGTVQQGQKAPSGVREEGGKPESVDGITLQANSSTRVTDISSQYKHQRVISRHHDKVPVTIRHESEMSTVNSFPEKCSEQENIASGISPQSASDNSRAEETQGSMDETSLKESSPSDDSITSPLSEDSQAGAEGVFVSPNKPRTTEDLFAVIHRSKRKVLGRKDSGDMSVRSKSRVPLGSSSSSANSVTSPSSNVTAGTSQRSPGLIYRNAKKSNTSNEEFKLLLLKKGSRSDSSYRMSATEILKSPVLPKPPGEFTAESPQSPDDTHQGTPGTEALSPLSPCSPRVNAEGFSSKNFATSASARVGRSRVPPVASSSRYSVRCRLYNTPMQAISEGETENSDGSPHDDRSSQSST
Protein: Coiled-coil domain-containing protein 93 (F8W9X7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRYGFSRQSKMEKAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS
Protein: Ubiquilin (Suppressor of NosA) (Q9NIF3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Stable protein which acts as an antagonist of nosA by repressing cellular differentiation after the tight-aggregate stage, when cells differentiate into two precursor cell types, prespore and prestalk cells, prior to the formation of fruiting bodies.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4
- UV excision repair protein RAD23 homolog
- PB1 domain-containing protein
- ZZ-type zinc finger-containing protein
- Ubiquitin-like domain-containing protein
- Proteasomal ubiquitin receptor ADRM1 homolog
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 2
- RING-type E3 ubiquitin transferase
- Ubiquitin conjugation factor E4 B
Sequence:
MVKINIKSSTDNKFDVDVELGITVADFKKVIATKCSIPADQQRIIYSGRILKDHQTLDEIKIQDGHTVHLVKGAAPPPPPPVEQQVPTPSNTQPQGIPGVPQNINDMMNNPMIQEMFNSRMMDSLLDNPDIFRDMMMGNPEMREVLNNNPEMAQMLSDPRQLRQSLEMMRNPELMREMMRNADRAMINIENHPEGFNLLRRMYTDIQEPLMNAANQQAASQNQTNSNPIQTNTDANPNSQPLPNPWSTNSSSTSSNPTSSSPSSRPTTGSSTNTGASNPWASMFSGGGGGMGGGTNNTGTNNTGSTNNTGASNPWASMFGGGGGGMGGMGGMEGMLGMDPERVQQLLNNPVAQQMMQRLMSDPAMMQQMITMNPQLRQMMDSNPQLREAMNNPEFLNMMTNPENMNAMMQLQQAMGTLRNNGVFPGGMGGMGGMGGMGGMGGMGGMDFSQFGNMFGGMGGMGGMGNNNSSTTRPPVNQEPPEQRFRLQLEQLEELGFVDRAANISALTSTNGNINLAIDRLLR
Protein: Uncharacterized protein, isoform E (M9PDX3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTLLGPSAPGMAFMMKKKKYKFNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEFPCKMSANASTGVLDPCHLRISIRKEMKGGRSYYKLGFIDLNLAEFAGAGLTSRRFLLEGYDSRHRLDNSMLRVSIKMHMLSGDILFKAPTPNLKSKQSKPSIDDFSNAATGVGLQIPTATALPSIGGGSGGASVSLGGSGVTLGGIPGNQSLPGTRPVSTTKEEDIDNQALIAAIVTDSGLSESSESGVTLTTDNLQQHGSVVVANPISPVTQALPQLGIIGSNNYGTTGGAIGFTGAGNATLIEMGHSRNSSNTSQMSKGSGYSSFSHSQHSRQSSEGDSGHARLNQRAINVMKFNIPHSRQNGQKGDEHQQCNSLRVVVAKSHHVHTHLSLSTTVEYASDEQLYQTPNATMTNSQKLAFEDFRTPMAELAAPLFQPMGAGCSGTPSSTYRSAGSPSHNTQYYDSGEASDTDECLNDESGDNDSGLEENFHTPRVAKIKSMENLSILEMEFHKASMELDRNSPRRLKQLAEHAQIPKMKSLNNLCFDHYAEQSVREEFQRMHEQSLEERMRFQQHHQLRKNSNASNGSATKIYVKHLSHQNHYHIKVGNAKFIGQDGNDSPQSMHYPIQKMRSMGTIQDIVSDRIEPDPFLTPTTERKPNFSRLVQSAEKPVLGSSYVNRLLTYDAVDSPSEPFNSSVSFMSRTPFQRAYRRNIQQGSSSTPLATQDFFAVRPHSTNAAYELMRNPSSGSLVISETGSLDRTKSSGEKRKKGALDDGPRVSDRVEETRVNPDSLIDEILKDTKLDQLEESAETSGLQLYIARDGTASLGGHEVKSSVRAGALKQVVMQDRR
Protein: Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) (P97700)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis. Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:3355813, ECO:0000305|PubMed:5083502}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Malate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase subunit gamma 1, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MAATASPGAGRMDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVXNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFVGPPAEVALIRMTADGRLPADQRRGYKNVFNALIRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCAIMISGLVTTAASMPVDIVKTRIQNMRMIDEKPEYKNGLDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG
Protein: Uncharacterized protein C24B11.07c (Q09894)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTDAGKKERVSILCVGSPSITTLLGWRLQQSSVVTCQETIMFFNAPEPSTNVFTIQSKKFGTRKYRPTYRLSKLEEVTSDSEPFDYVFVSIKPNSRNFQLSNILEPVITAKHTCIVYNSTGAIGVEEALQRQYPENPIFSLITHTPVSQRSVDEFFFGDCAPFYLAPAGSNLEIDQLSRLVEILEGGEISSEILDTLLPLEIEDLALPLSLYPLTVLTQNPNLPKLLERPDINDLHQGILQELDSLCNCLGSSLDVKKLSKQRETLLSHMQVNPAFREYRSNRPVEIVQYLHYCIDLATKQSLQVPRLRTISALISSIQHLPLVQPHHMNDMHGPTDNSPKKNKVLVNMRPINPSSFVSDRHSPLHPYSVPENGKPNMGRIPSAPSLSKGRAMTADNMDMLSLTTRRSRRSLYSPSLMQMQQSLKSDYEGLGRTFDPRFAPRGSPPVRGGKNVLSPEAKEHTHKNISPESSRFGTPSDPNSSSQSLGNEVLSRPNSNSNSAESRNGETDDSGESETYFTLMNNNKGVEPRASVASETSSMTVIPNAMRRFPLARGTSRMKS
Protein: FI24033p1 (Tumbleweed) (A1Z9I5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Kinesin-like protein
- Anillin
- Protein nessun dorma
- Pebble, isoform B
- Kinesin-like protein subito
- Aurora kinase B
- Kinesin-like protein Klp61F
- Inner centromere protein, isoform A
- Fascetto
- Borealin
Sequence:
MALSALASFDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHARRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIVIDPTRTPATVIKRVPSNKNDLLSLYATPFKGGTIKKRKFYGTPPASAHKK
Protein: SLAM family member 5 (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84) (Q18PI6)
Organism: Mus musculus (Mouse)
Function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells (By similarity). Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (By similarity). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- SH2 domain-containing protein 1A
- SH2 domain-containing protein 1B
- SH2 domain-containing protein 1B2
Sequence:
MAQRHLWIWFLCLQTWSEAAGKDADPMVMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPRHAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEADDVSKKTVYAVVSRNAQPTESRIYDEIPQSKMLSCKEDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV
Protein: Protein phosphatase eya-1 (EC 3.1.3.48) (Eyes absent homolog 1) (O17670)
Organism: Caenorhabditis elegans
Function: Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Plays a role in locomotion and fertility. May play a role in resistance to heat and oxidative stresses. May cooperate with the transcription factors vab-3 and ceh-32 to repress transcription factor ets-5 expression in non BAG neuronal cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:16154558, ECO:0000269|PubMed:19427847}.
Interaction partners:
- Homeobox protein ceh-34
- Homeobox protein unc-39
- Dachshund homolog dac-1
- Homeobox protein ceh-32
- Homeobox protein ceh-33
- Paired box protein 6 homolog
- Paired box protein 2 homolog
- Paired box protein 3 homolog
- Transcription factor sox-2
Sequence:
MLPDSEGQKLKTFLLGTGTTLDPSLDPTGNSNFSMATTSDSSTIWTALPASQPGDKDIPTVDLAAISEAYGSTSSTTSLTSSVTSQYQYNSYPQYAMYTSANPANYYQQVTANLRAGTTAFPYSLTTPSYYGSYPVDYTSAAAAYQNPYYTNLRGGTAAPYYNPLNATTAAAYASVASSVLGTDAVNLGTSSDGSTGVPSTVTSFSLKEKKPKVSKKKKTGSCSPGDETYARVFIWDIDDIAVISRNYLASVTHTNEFYARAANSVSHLMERIALNNFADVNEFLEGDITNIEDAVVDETTMDSGPIDNLRGLDVMRRVAPKYSAFRQFYTENSTKNDVAGFKQEQNGFNFELLERVGFGAREATELYQSAIQLQTLPNFGQRWPCAQRCMDLVVEKSKLSAEKYANVVLSNDGLVLGAAQLMISGLNSSVPVENIYSISKQGKESVFEKIQSRFGKKCSFICITSGDTANSAKRLNIPVWPLNSNTDLDKLYSALDNFLLGG
Protein: Cadherin 3 (F1LMI3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
Interaction partners:
- Junction plakoglobin
- Catenin beta-1
- Catenin delta 1
- Cadherin-1
- Nephrin
- Podocin
- Catenin alpha-1
- Cadherin-2
- Tight junction protein ZO-1
- Cadherin 11
Sequence:
MELLSGPLVFLLLLLQVCWLRSVVSESYREDFIREAGVTLEVGGTDLEPSQALEKEALAGHEVLGADSGGIITLNRETVQGGKGVMNSPPSRILRRRKREWVMPPISVPENGKGPFPQRLNQLKSNKDRGTKLFYSITGPGADSPPEGVFTIEKETGWLLLNMPLDREKIVKYELFGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVPEGVMPGTSVMQVTATDEDDAINTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAEAVVQILDTNDNAPEFQPQKYEAWVPENAVGHEVQRLTVTDLDSPNSPAWRATYHIVGGDDGDHFTVATHPETNQGILTTKKGLDFEAQNQHTLYIEVTNEASFAVKLPTATATVVVHVEDVNEAPVFVPPSKVIEAQEGISIGELVCVYTAQDPDKEEQKISYSILRDPASWLAVDPDSGQITAAGILDREDEQFVKNDIYEVMVLATDNGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTMIRATVCDCHGQVLNDCPRPWKGGFILPVLGAVLALLTLLLALLLLVRKKRKVKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLTEWGSRFKKLADMYGGGEDD
Protein: Runt-related transcription factor (H9KVB1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009374}.
Interaction partners:
Sequence:
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY
Protein: Protein TOC75-3, chloroplastic (75 kDa translocon at the outer-envelope-membrane of chloroplasts 3) (AtTOC75-III) (Q9STE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. Mediates the insertion of proteins targeted to the outer membrane of chloroplasts (By similarity). Required for the import of protein precursors into chloroplasts. Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:15090618}; Multi-pass membrane protein {ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:15090618}.
Interaction partners:
- Translocase of chloroplast 159, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- Protein TIC110, chloroplastic
- Translocase of chloroplast 33, chloroplastic
- Protein TIC 22, chloroplastic
- Translocase of chloroplast 120, chloroplastic
- Protein TIC 40, chloroplastic
- Protein TIC236, chloroplastic
- Translocase of chloroplast 132, chloroplastic
- Translocase of chloroplast 90, chloroplastic
Sequence:
MAAFSVNGQLIPTATSSTASTSLSSRRKFLSPSSSRLPRISTQSPRVPSIKCSKSLPNRDTETSSKDSLLKNLAKPLAVASVSSAASFFLFRISNLPSVLTGGGGGGDGNFGGFGGGGGGGDGNDGGFWGKLFSPSPAVADEEQSPDWDSHGLPANIVVQLNKLSGFKKYKVSDIMFFDRRRQTTIGTEDSFFEMVSIRPGGVYTKAQLQKELETLATCGMFEKVDLEGKTKPDGTLGVTISFAESTWQSADRFRCINVGLMVQSKPIEMDSDMTDKEKLEYYRSLEKDYKRRIDRARPCLLPAPVYGEVMQMLRDQGKVSARLLQRIRDRVQKWYHDEGYACAQVVNFGNLNTKEVVCEVVEGDITQLVIQFQDKLGNVVEGNTQVPVVRRELPKQLRQGYVFNIEAGKKALSNINSLGLFSNIEVNPRPDEKNEGGIIVEIKLKELEQKSAEVSTEWSIVPGRGGAPTLASFQPGGSVTFEHRNLQGLNRSLMGSVTTSNFLNPQDDLSFKLEYVHPYLDGVYNPRNRTFKTSCFNSRKLSPVFTGGPGVEEVPPIWVDRAGVKANITENFTRQSKFTYGLVMEEITTRDESSHIAANGQRLLPSGGISADGPPTTLSGTGVDRMAFLQANITRDNTKFVNGAVVGQRTVFQVDQGLGIGSKFPFFNRHQLTMTKFIQLREVEQGAGKSPPPVLVLHGHYGGCVGDLPSYDAFVLGGPYSVRGYNMGELGAARNIAEVGAEIRIPVKNTHVYAFVEHGNDLGSSKDVKGNPTAVYRRTGQGSSYGAGVKLGLVRAEYAVDHNNGTGALFFRFGERY
Protein: Beta-catenin-like protein hmp-2 (Protein humpback-2) (O44326)
Organism: Caenorhabditis elegans
Function: Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions.
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:25850673, ECO:0000269|PubMed:9531567}.
Interaction partners:
- Alpha-catenin-like protein hmp-1
- Cadherin-related hmr-1
- Protein pop-1
- Juxtamembrane domain-associated catenin
- Adenomatous polyposis coli protein-related protein 1
- Armadillo repeat-containing protein wrm-1
- Glycogen synthase kinase-3
- F-box/WD repeat-containing protein lin-23
- Protein kinase domain-containing protein
- Casein kinase I isoform alpha
Sequence:
MLLHSTNSYSIFTDHEVETRTSRIRSAMFPDWIPPTSAAEATNSTTSIVEMMQMPTQQLKQSVMDLLTYEGSNDMSGLSLPDLVKLMCDHDESVVARAVHRAYMLSREDPNFFNAPGFDHRSFVEALMAASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATNEENLTQLIIKLLEIIRVANDGMTACACGTLSNLTCNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTARHSLAEEAQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKRPDGARAVESTGVSALLMESRGSQYKSVVTYANGVLSNLKRGDSAAIMNMSNSYDYEMSGSAADWQRDGLERELFAEMYPTNDGGHSESINMALNNSQMRPNHNWYDTDL
Protein: Salivary thrombin inhibitor anophelin (cE5) (Q7Q3R9)
Organism: Anopheles gambiae (African malaria mosquito)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MASKLFVLAFLCLALVVVVQSAPQYARGDVPTYDEEDFDEESLKPHSSSSSDDGEEEFDPSLLEEHADAPTARDPGRNPEFLRNSNTDEQASAPAASSSESDE