wanglab/gogpt-training-data huggingface dataset:
Protein: Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D) (Q6UB28)
Organism: Homo sapiens (Human)
Function: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:14532271}.
Interaction partners:
- Electron transfer flavoprotein subunit beta
- Iodotyrosine deiodinase 1
- Microtubule-associated protein 1B
- Electron transfer flavoprotein subunit alpha, mitochondrial
- Adrenodoxin, mitochondrial
- Ferredoxin-2, mitochondrial
Sequence:
MAAPSGVHLLVRRGSHRIFSSPLNHIYLHKQSSSQQRRNFFFRRQRDISHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA
Protein: Mitochondrial thiamine pyrophosphate carrier 1 (A0A1D8PNY6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Isocitrate lyase
- Malate synthase
- fructose-bisphosphatase
- Citrate synthase
- Carnitine O-acetyltransferase, mitochondrial
- Isocitrate dehydrogenase
- Phytanoyl-CoA dioxygenase
- Acyl-coenzyme A oxidase
- Carnitine O-acetyltransferase
- Peroxisomal hydratase-dehydrogenase-epimerase
Sequence:
MSSTQKQKKGAVDFVAGGVAGLFEALCCHPLDTIKVRMQLYKKSGQKPPGFIKTGANIVQKEGFLSLYKGLGAVVIGIVPKMAIRFSSYEFYRSFFLDENGKISTGKTFLAGVGAGITESVMVVNPMEVVKIRLQAQHHSMKDPLDIPKYRNAPHAAYLIVKEEGFSTLYRGVSLTCARQATNQGANFATYSTIKAYLQKQQNTELLPAWQTSIVGLISGAVGPLTNAPLDTIKTRLQKSKFTNKENGLVRIVKIGKQLVKEEGINALYKGITPRIMRVAPGQAVVFTVYEAVKHYLTNEPTA
Protein: Vacuolar protein sorting-associated protein 54 (Protein scattered) (Q9VLC0)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity). Required during spermatogenesis for sperm individualization.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 52 homolog
- Vacuolar protein sorting-associated protein 53 homolog
- FI23003p1
- Vacuolar protein sorting-associated protein 51 homolog
- RH33377p
- Syntaxin 16
- HL02043p
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 7
Sequence:
MATTRSAGGAATSVDTGPAAGNSGIRKLSTASVGGIAGGVAPSWQSCYYCTREHFKSISDFVNHLRNRHCTREGGSFVCRYGFNGVCASLPLDGVSDRDYDAHVAKYHVNQHTREMPPEWGVYSAAQNLPAVLNDPSRGKQSNLFTKKWGEHFVERSHVPPSPRLPDITHADFTVYLGSIGKRYRWHERRQQQLERDKPLENGAQGAPGPGTGGQTPTHLSSVPEIFLKSQLQLHHPATFKQVFPNYMQTSASSPESHQQTGRQLQEQLSHYLDMVEVKIAQQVSQKSAAFFHAMTTQHAILAEMEQAADQVRQLRAALAELHSHSVVDSFKVLRFAQRRQHYNLTLDKLRLMATVHKTQPMLQLLLGTQDYVAALDLIGTTQEILSAELLGIHCFKHLPMQLSEMEKLIDKMLTTEFERYAAADLNRPLTDALRETDSVCAEEDKLVAIVMGLLRKQNFSFVQAYQQEAIATIRAIIKQLLIEVLARSDSDQEISLTGHGEQALELTLPEWIALLQRSSQALVSILERIKTVVGIMQQTADAAVGAQDAVNLIDSEAFLSPGHHEQLKNQLQQLLQAVCHYCHERCANIVSPQSLERSSASEQELFQLSEIVDHFGETTRSICGVASVPLQLALKVQASRYAQRFHSERKQKLSLLLDQERWRQVDIPHEFQRIIERMAAGDYAKPEMGNLISNGAGNPVLLVEGKQPYTLVSASLMLIRMLYEYGCSAHRLPLLASYHARNVVDLLRCFNSRSCQLIIGAGAMRVAGLKTITSTNLALVSRALQLVLWLLPKLKEHFQAMSGYETIERDYQGHIKEIENKIHGIVSERLAAQLDAWEARPPIPSQTFRHISRHLVKLHEAIAGVLPEAQIHEIYGVVHRNFKDKLREQLLKLNVNNNGGPQHGVVTSELTFYMETLRTLKALPAEQLDNGILEEIWLY
Protein: Basigin, isoform J (M9PCW5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEAKFLASALSFLSIFLAIYAQSLDKLVPNYDNAEHQMKFYDIRSPLVLSCNVKDGTPGGVLIWKKNGTAVTDVPSLRGRFKLIADENKFIIDKTDTNDDGKYSCEFDGVSKEIEVIARVVVRVPSNTAVVEGEKMSVTCSVVGTKPELTWTFANVTLTNATDRFILKPDDNGVPNAILTLDNVTLDDRGEYKCIGRNAANVYGGNTTTPASDVTTVRVKGKFAALWPFLGICAEVLILCIIILIYEKRRNKSELEESDTDPQEHI
Protein: Nucleolar complex-associated protein 3 (Q07896)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Also required for initiation of DNA replication. May function downstream of the origin recognition complex (ORC complex) in the loading of CDC6 and the minichromosome maintenance complex (MCM complex) onto chromatin during the G1 phase of the cell cycle. Essential for growth.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11371346}.
Interaction partners:
- ATP-dependent RNA helicase HAS1
- Ribosome biogenesis protein RPF2
- ATP-dependent rRNA helicase SPB4
- Ribosome biogenesis protein 15
- Pescadillo homolog
- 25S rRNA
- Protein MAK16
- rRNA-processing protein EBP2
- Origin recognition complex subunit 5
- Ribosome biogenesis protein MAK21
Sequence:
MAKRNRSQFRIQERTAKKRKHEDSLLEGNVFQNAPEDMDENTIYSAKGSSWDEEEQDYEMVPRKNRSDTSNLVEGLPIKVNGKVERKLHKAQEKPKDDDEEDEDSNDSSEDDEGPNEEQEAEAKEDEPDTEEKILQLKEDIADLVTKVMEEPEENTAALGRLCKMVESKNPNTCKFSMLALVPVFKSIIPGYRIRPLTETEKKEKVSKEVSKLRNFEQALVYNYKNYVGRLQSLSKTPSNAAPIQVSLGILATQAAKELISTASHFNFRTDIFTLLLRRICKPRISTDPTSIQIIQTFETLLNEDEEGSISFEILRIFNKILKTRNFNIEESVLNMLLSLDVLHDYDPNTKLKGNVSAPKLKKKDRVHLSKKQRKARKEMQQIEEEMRNAEQAVSAEERERNQSEILKIVFTIYLNILKNNAKTLIGSVLEGLTKFGNMANFDLLGDFLEVMKELISDTEFDNLSSAEVRKALLCIVSAFSLISNTQYMKVNVDLSKFVDGLYALLPYICLDADIELSYRSLRLADPLNNEIIKPSVNVSTKAELLLKALDHVFFRSKSGTKERATAFTKRLYMCISHTPEKTSIAILKFIDKLMNRYPEISGLYSSEDRIGNGHFIMEADNPSRSNPEAATLWDNALLEKHYCPVVTKGLRSLSSRSKECSK
Protein: Nuclear protein 1b (E9QCY4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Si:ch73-147o17.1
- Centromere protein W
Sequence:
MSNHVEVKNIEPTTFENRYYDEYEYYNLTDRYTECTSRKGRTKKEASCNTNRPNPAGHERKIVEKLQNAEKNSKE
Protein: Golgin subfamily A member 4 (tGolgin-1) (Q91VW5)
Organism: Mus musculus (Mouse)
Function: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12162805}. Golgi apparatus membrane {ECO:0000269|PubMed:12162805}; Peripheral membrane protein {ECO:0000269|PubMed:12162805}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q13439}.
Interaction partners:
- ADP-ribosylation factor-like protein 1
- Golgin subfamily A member 1
- GRIP and coiled-coil domain-containing protein 2
Sequence:
MFKKLKQKISEEQQQLQQALAPAQASSSSSTPTRTRSRTSSFTDQLDDVTPNRENASTQATKSPDGVSKDESSPSQSGDTQTFAQKLQLRVPSMESLFRSPIKESLFRSSKEPLVRTSSRESLNQLDLDCSAAAFDPPSDMESEAEDAPWNSDGLSREQLLQRLRRMERSLSSYRGKYSELVTAFQTLQREKKKLQGILSQSQDKSLRRISELREELQMDQQAKKHLQDEFDACLEEKDQYISVLQTQVSLLKQRLQNGPMNVDAPKPLPPGELQAEVHGDTEKMEGVGEPVGGGTSAKTLEMLQQRVKRQENLLQRCKETIGSHKEQCALLLSEKEALQEQLDERLQELEKMKELHMAEKTKLITQLRDAKNLIEQLEQDKGMVITETKRQMLETLELKEDEIAQLRSHIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEDAQRRMKMEMDEQMKAVERASEEERLRLQHELSRVRQEAASMAKKNSEEQVAALQKLHAEELASKEQELSRRLEARERELQEQMRIALEKSRSEYLKLTQEKEQQESLALEELELQKKAILTESENKLQELGQEAEAYRTRILELETSLEKSLQESKTQSEHLAVHLEAEKNKHNKELTALAEQHRTEVEGLQQQQDSLWTERLQSLSQQHQAAVEELREKYQQEKDALLKEKESLFQAHIQDMNEKTLEKLDKKQMELESVSSELSEALRARDQLAEELSVLRGDADKMKQALEAELEEQRRHHQREVGSISEQQELTVRRAEKALKDELSRLGALLDERDEHLRERQARVQDLEAHLQKSAGELQQALAKLDLLHSEQSAAREQAGAYEEQLAQMQQKVLDLETEKSLLTKQVVEMETHKKHVCEELDAQRAQVQQLERQRSELEEKVRSLAQLQDSQLKNSTVEKEQARQSLMEKENIILQMREEQAKEIEILKQTLSSKEESISILHEEYETKFKNQEKRMEKIKQKAKEMQETKKKLLDQEAKLKKELENTVLELSQKEKQFNAQILEMAQANSAGISDTVSRLEENQRQQIESLTGAHQRKLDDVIEAWEKKLSQQAAELRDKHAEQMEEKEQGLGELRQKVRIVQSEKEELTKEVARLKEAVSGQDVALAGLQGQLEQKSAVIVSLSERESQLQSQVEKLEADLGCSLSEKLSLQEELAELKLLADKSQLRVSELTGQVQAAEKELQSCKSLHELSKKSLEDKSLNLKSLLEELASQLDSRCERTKALLEAKTNELVCTSRDKADAILARLSQCQRHTATVGEALLRRMGQVSELEAQLTQLTEEQRTLKSSFQQVTNQLEEKEKQIKTMKADIEGLLTEKEALQQEGGQQRQAASEKESCITQLKKELAENINAVTLLREELSEKKSEIASLSKQLSDLGAQLESSISPSDKAEAISALSKQHEEQELQLQAQLQELSLKVDALSKEKMSALEQVDHWSNKFSEWKKKAQSRLAQHQSTIKDLQAQLDVKATDAREKEEQICLLKEDLDRQNKKFECLKGEMEVRKSKMEKKECDLETALKTQTARVVELEDCVTQRKKEVESLNETLKNYNQQRDTEHSGLVQRLQHLEELGEEKDNKVREAEETVLRLREHVSSLEAELGTVKKELEHVNSSVKSRDGELKALEDKLELESAAKVELKRKAEQKIAAIRKQLLSQMEEKTQRYAKDTENRLSELSAQLKEREKQVHSLEDKLKNLESSPHPEVPAVSRSMQSVAASPEQEAPDSQDCTHKACKERLCMLQRRLSEKEKLLRRLEQGEGEARPSQPEAQHRALSGKLDCTRARQLEDHVLIGCLPEELEEKMKCSLIVSQPMGEETGNNTGVKQNWASVVDSVQKTLQEKELTCQALEQRVKELESDLVRERGAHRLEVEKLTLKYEKSQSSQQEMDGENKCVEVLEDRPEENSQSHEIQSNVGTVDGLRSDLESKLTGAERDKQKLSKEVARLQKELRALRREHQQELDILKRECEQEAEEKLKQEQEDLELKHTSTLKQLMREFNTQLAQKEQELERTVQETIDKAQEVEAELLESHQEETQQLHRKIAEKEDDLRRTARRYEEILDAREEEMTGKVTDLQTQLEELQKKYQQRLEQEESTKDSVTILELQTQLAQKTTLISDSKLKEQELREQVHNLEDRLKRYEKNACAATVGTPYKGGNLYHTEVSLFGEPTEFEYLRKVMFEYMMGRETKTMAKVITTVLKFPDDQAQKILEREDARLMSWLRTSS
Protein: Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2'] (A0A2R4KP93)
Organism: Middle East respiratory syndrome-related coronavirus (MERS-CoV)
Subcellular location: Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00034689, ECO:0000256|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04099}. Virion membrane {ECO:0000256|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04099}. Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04099}. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. {ECO:0000256|HAMAP-Rule:MF_04099}.
Interaction partners:
Sequence:
MRLSVCLLMFLLTPIKGDVDSGPPSSATSCKEADMRNSSSEFFNKQWPMPINASKADGIIYPTGKSYSNISLTLQGLFPKHGDLGEQYIYSVGHSDSNYDYLGKLFVSDYATKVVPFNNGFVVRIGAAANATGSVIISTVQKTIKKIYPAFMLGSSVGNFSNGVSGRYFNHTLLLLPDGCGTRLWALYCVIEPRNGSYCPGNSNYNTFAVFDTPHTDCTSAGYNTNATLNSFKEYFDLQNCSFIYSFNITEDENAEWFGITQNTQGVHLYSSRKGDLYGSNMFLFATLPVYDGIKYYTVIPRSIRSKYSERQAWAAFYIYSLHKLTYLLDFSVDGYIRRAVDCGHDDLSQLYCSYESFDVGSGVYSVSSFEVHSRGQFIEQPNSVECDFTKLLSGTPPQVYNFNRLVFTNCNYNLTKLLSLFMVNEFSCDGISPDAIARGCYSSLTVDYFAYPLSMKSYMQPGSAGVISQYNYKQSFANPTCRIFATAPANLTITKPSSYSFISKCSRLTGDNSHIETPIVINPGEYSICKNFAPNGFSQDGDYFTRQLSQLEGGGILVGVGSVTPMTDTLQMGFIISVQYGTDTNSVCPMMDLGNSTTITDKLGVCVEYNLYGVSGRGVFINCTAVGVKQQRFVYDGFDNLIGYYSDDGNYYCVRPCVSVPLSVVYDKTTNSHATIFGSVACEHITTMLHQFSRTTQASLRMRDVSNSGPLQTAVGCVIGLVNSSMVVDNCQLPLGQSLCAVPSTTRSSSQLQLATINYTQPQLLSPLNSSGFVVQVPTNFSFGITQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCAKINQALHGANLMQDESVANLFSDIKTHKSQPLNAGLNGDFNLTLLQVPQVSTSQYSHRSAIEDLLFNKVTIADPGYMQGYDDCMKQGPPSARDLICAQYVAGYKVLPPLYDPNMEGAYTSSLLGSIAGAGWTAGLSSFAAIPFAQSIFYRMNGIGITQQVLSENQKLIANKFNQALGAMQTGFTTTNLAFSKVQDAVNANAQALSKLASELSNTFGAISSSISDILKRLDAVEQEAQIDRLINGRLTSLNAFVAQQLVRSETAARSAQLASDKVNECVKSQSKRNGFCGSGTHIVSFVINAPNGFYFFHVGYVPTNHVNVTAAYGLCNTDTPPRCIAPIDGYFVLNNTTTRDVVDQWYYTGSSFFNPEPITMANARYVSQDVKFENLTNQLPPPLLNNQTDLDFKEELEEFFKNVSSQGPNFQEISKINTTLLDLSTEMKVLNEVVKQLNESYIDLKELGNYSYYQKWPWYIWLGFIAGLVALALCVFFLLCCTGCGTNCMGKLKCNRCCDKYDDLEPLKIHVH
Protein: Aldo-keto reductase family 4 member C11 (EC 1.1.1.-) (Q9M338)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Oxidoreductase that may act on a broad range of substrates such as ketosteroids, aldehydes, ketones and sugars.
Interaction partners:
- Probable aldo-keto reductase 1
- At2g27680/F15K20.22
- Probable voltage-gated potassium channel subunit beta
- NAD
- UDP-glycosyltransferase 91B1
- Cytochrome P450, family 706, subfamily A, polypeptide 7
- NAD
- Cytochrome P450, family 705, subfamily A, polypeptide 9
- At4g12320
- NAD
Sequence:
MADEIGFFQLNTGAKIPSVGLGTWQAAPGVVGDAVAAAVKIGYQHIDCASRYGNEIEIGKVLKKLFDDGVVKREKLFITSKIWLTDLDPPDVQDALNRTLQDLQLDYVDLYLMHWPVRLKKGTVDFKPENIMPIDIPSTWKAMEALVDSGKARAIGVSNFSTKKLSDLVEAARVPPAVNQVECHPSWQQHKLHEFCKSKGIHLSGYSPLGSPGTTWVKADVLKSPVIEMIAKEIGKSPAQTALRWGLQMGHSILPKSTNEGRIRENFDVLGWSIPKEMFDKFSKIEQARLVQGTSFVHETLSPYKTLEELWDGEI
Protein: Large ribosomal subunit protein uL2z (60S ribosomal protein L2) (60S ribosomal protein L8-1) (Protein EMBRYO DEFECTIVE 2296) (P46286)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL3z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein eL13z
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein uL4z
Sequence:
MGRVIRAQRKGAGSVFKSHTHHRKGPAKFRSLDFGERNGYLKGVVTEIIHDPGRGAPLARVTFRHPFRFKKQKELFVAAEGMYTGQFLYCGKKATLVVGNVLPLRSIPEGAVVCNVEHHVGDRGVLARASGDYAIVIAHNPDSDTTRIKLPSGSKKIVPSGCRAMIGQVAGGGRTEKPMLKAGNAYHKYRVKRNSWPKVRGVAMNPVEHPHGGGNHQHIGHASTVRRDAPPGQKVGLIAARRTGRLRGQAAASAAKAD
Protein: Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) (O14966)
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity. Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
Subcellular location: Cell membrane {ECO:0000269|PubMed:38127736}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24788816}. Golgi apparatus {ECO:0000269|PubMed:22042847}. Golgi apparatus membrane {ECO:0000269|PubMed:38127736}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}. Vacuole {ECO:0000269|PubMed:22042847}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22042847}. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847, PubMed:38127736). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.typhi) infected epithelial cells, is recruited and colocalized with both S.typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847). {ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}.
Interaction partners:
- Leucine-rich repeat serine/threonine-protein kinase 2
- Cyclin-G-associated kinase
- Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
- Solute carrier family 41 member 1
- N-fatty-acyl-amino acid synthase/hydrolase PM20D1
- BAG family molecular chaperone regulator 5
- Guanine nucleotide exchange protein SMCR8
- Geranylgeranyl transferase type-2 subunit alpha
- Guanine nucleotide exchange factor C9orf72
- Solute carrier family 45 member 3
Sequence:
MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC
Protein: Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) (Delta crystallin II) (Delta-2 crystallin) (P05083)
Organism: Gallus gallus (Chicken)
Function: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase.
Interaction partners:
- Argininosuccinate synthase
- Ornithine aminotransferase
- Arginase
- Adenylosuccinate lyase
- Nitric oxide synthase, inducible
- Nitric oxide synthase
- Nitric oxide synthase
- Uncharacterized protein
- Ornithine transcarbamylase, mitochondrial
- Citrate synthase, mitochondrial
Sequence:
MASEGDKLWGGRFSGSTDPIMEMLNSSIACDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLLLKSSISVISTHLLQLIKTLVERAATEIDVIMPGYTHLQKALPIRWSQFLLSHAVALIRDSERLGEVKKRMSVLPLGSGALAGNPLEIDRELLRSELDFASISLNSMDAISERDFVVELLSVATLLMIHLSKLAEDLIIFSTTEFGFVTLSDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAVLMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQVNKENMEKALTPELLSTDLALYLVRKGMPFRQAHVASGKAVHLAETKGIAINKLTLEDLKSISPLFASDVSQVFNIVNSVEQYTAVGGTAKSSVTAQIEQLRELLKKQKEQA
Protein: DNA polymerase delta subunit 3 (Q4V7D0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAEQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYEYVERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDRLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSRKFEQSNLQAASETQASELTTNGHGPPASKQASQQPKGIMGMLISKAATKTQDTNKDTKTEAREVTSASSAGGKAPGKGNVMSNFFGKAAMSKLKVNLDSEQAVKEEKTVEQPPVSVAEPKLAAPPALKKSSRKSEPVKMQQKEKKCRGKRVDLSDEEAKETENLKKKRRRIKLPQSDSSEDEVFADSPEMFEAVSPSPPPASPPPDPVPKTEPPPVKRSSGENKRKRKRVLKSKTFVDEEGCMVTEKVYESESCTDSEEETKMKMASAQRPPAATVKREPREERKGPKKGAAALGKANRQVSITGFFQKK
Protein: Dihydropteridine reductase (EC 1.5.1.34) (Quinoid dihydropteridine reductase) (Q86A17)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Interaction partners:
- Phenylalanine-4-hydroxylase
- Pterin-4-alpha-carbinolamine dehydratase
- Sepiapterin reductase
- dihydrofolate reductase
- Aldose reductase B
- Aldose reductase C
- Aldose reductase A
Sequence:
MSKNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNADHSFTIKDSGEEEIKSVIEKINSKSIKVDTFVCAAGGWSGGNASSDEFLKSVKGMIDMNLYSAFASAHIGAKLLNQGGLFVLTGASAALNRTSGMIAYGATKAATHHIIKDLASENGGLPAGSTSLGILPVTLDTPTNRKYMSDANFDDWTPLSEVAEKLFEWSTNSDSRPTNGSLVKFETKSKVTTWTNL
Protein: Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1) (O95248)
Organism: Homo sapiens (Human)
Function: Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:35580604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12668758}. Cell projection, neuron projection {ECO:0000269|PubMed:35580604}. Note=Localized in neuronal somata and processes with punctate/vesicular morphology. {ECO:0000269|PubMed:35580604}.
Interaction partners:
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Phosphatidylinositol-3-phosphate phosphatase MTMR1
- Fizzy-related protein homolog
- Histone-lysine N-methyltransferase 2A
- Ras-related protein Rab-21
Sequence:
MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFWEPAEPSQQETTRVEDATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSLKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENPYPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVPSGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTESGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKKTIGRQHVTRKKYNPPSWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSSAHMGSHGKWGSVRTSGRSSGLGTDVGSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQSRRRVVWPCYDSCPRAQPDAISRLLEELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA
Protein: Ferritin, putative (O29424)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Interaction partners:
- Desulfoferrodoxin homolog
- Putative superoxide reductase
- Rubrerythrin
- Rubrerythrin
- Peroxiredoxin
- Ferric-chelate reductase
- Ferrous iron transport protein B
- Uncharacterized protein AF_0835
- Iron-sulfur flavoprotein AF_1896
- Iron
Sequence:
MASISEKMVEALNRQINAEIYSAYLYLSMASYFDSIGLKGFSNWMRVQWQEELMHAMKMFDFVSERGGRVKLYAVEEPPSEWDSPLAAFEHVYEHEVNVTKRIHELVEMAMQEKDFATYNFLQWYVAEQVEEEASALDIVEKLRLIGEDKRALLFLDKELSLRQFTPPAEEEK
Protein: Cytochrome c oxidase assembly factor, putative (Q38EA7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|PIRNR:PIRNR037736}.
Interaction partners:
- Cytochrome oxidase assembly protein, putative
Sequence:
MRRVSGNVLCGSASHWRAELMPTVLCAPHRLGSGARTSVDDEKEIEKDREALRKYSVFAGMTVLCAATLWYGSEKAKKRYFGSQGSARVSVETRGRPALGGPFVLVNTDGEPVSQAEFLGSWAFFYFGFTHCPEICPVELNRMSKVIDAVRAKRPNQKIVPLFVSCDPRRDSLEAIAEYLSVFHESFVGLVGTPKQVSDACKSYRIYYSLPSEEAAEQNDYLIDHSIAIFLFDPKGRFVDFFGSRYDENEITERVLGYMDQLERDPEWTNW
Protein: Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2) (O15460)
Organism: Homo sapiens (Human)
Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular location: Endoplasmic reticulum lumen.
Interaction partners:
- Protein disulfide-isomerase
- Prolyl 4-hydroxylase subunit alpha-1
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- Pyrroline-5-carboxylate reductase 3
- Proline dehydrogenase 1, mitochondrial
- Hydroxyproline dehydrogenase
- Proline dehydrogenase
- Pyrroline-5-carboxylate reductase 2
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Cytosol aminopeptidase
Sequence:
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD