wanglab/gogpt-training-data huggingface dataset:
Protein: bZIP transcription factor 46 (OsBZIP46) (AREB/ABF-family transcription factor 8) (OsAREB8) (Abscisic acid responsive elements-binding factor 2) (ABRE-binding factor 2) (OsABF2) (Abscisic acid responsive elements-binding factor 3) (ABRE-binding factor 3) (OsABF3) (Protein ABI5-LIKE 1) (Q69TW5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in abscisic acid (ABA) signaling pathway. Transcription factor activity is fully activated by ABA. Acts as positive regulator of the expression of abiotic stress-responsive genes through an ABA-dependent signaling pathway. Acts as positive regulator of ABA signaling and drought stress tolerance. Plays an important role in ABA and auxin responses. Involved in ABA signaling and stress responses by directly binding to the ABA-responsive element (ABRE)-containing genes, especially WRKY family genes. Modulates response to auxin. Suppresses auxin signaling by targeting ABRE-containing genes related to auxin metabolism or signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:20576316, ECO:0000269|PubMed:21546455, ECO:0000269|PubMed:22301130, ECO:0000269|PubMed:26300907, ECO:0000269|PubMed:27468891}.
Interaction partners:
- Serine/threonine-protein kinase SAPK6
- Serine/threonine-protein kinase SAPK10
- Serine/threonine-protein kinase SAPK9
- Serine/threonine-protein kinase SAPK2
- Serine/threonine-protein kinase SAPK4
- Serine/threonine-protein kinase SAPK1
- Serine/threonine-protein kinase SAPK3
- Serine/threonine-protein kinase SAPK7
- Os05g0433100 protein
- Ninja-family protein MODD
Sequence:
MELPADGSALARQGSIYSLTFDEFQSALGSAEKDFGSMNMDELLRNIWTAEESQAIAPAAAAASAAAVVGDAQQQQQPIQRQGSLTLPRTLSQKTVDEVWRDIMGLGGSDDEDPAAAAAAAAPAQRQPTLGEMTLEEFLVRAGVVREDMGQTIVLPPQAQALFPGSNVVAPAMQLANGMLPGVVGVAPGAAAAMTVAAPATPVVLNGLGKVEGGDLSSLSPVPYPFDTALRVRKGPTVEKVVERRQRRMIKNRESAARSRARKQAYIMELEAEVAKLKEQKAELQKKQVEMIQKQNDEVMERITQQLGPKAKRFCLRRTLTGPC
Protein: Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (O70237)
Organism: Mus musculus (Mouse)
Function: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:12594258}. Note=Localized at foci of pericentric heterochromatin.
Interaction partners:
- Erythroid transcription factor
- Lysine-specific histone demethylase 1A
- REST corepressor 2
- T-cell acute lymphocytic leukemia protein 1 homolog
- Histone deacetylase 1
- Rhombotin-2
- Endothelial transcription factor GATA-2
- Protein lyl-1
- Integrin alpha-IIb
- LIM domain-binding protein 1
Sequence:
MPRSFLVKSKKAHTYHQPRAQGDELVWPPAVIPVAKEHSQSASPLLSTPLPSQTLDWNTIKQEREMLLNQSLPKMASAPEGPLVTPQPQDGESPLSESPPFYKPSFSWDTLASSYSHSYTQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFRLRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
Protein: Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) (Q9NXD2)
Organism: Homo sapiens (Human)
Interaction partners:
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Fanconi-associated nuclease 1
- Transient receptor potential cation channel subfamily M member 1
- OTU domain-containing protein 7A
- Intraflagellar transport protein 80 homolog
- Krueppel-like factor 13
Sequence:
MFSLKPPKPTFRSYLLPPPQTDDKINSEPKIKKLEPVLLPGEIVVNEVNFVRKCIATDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEHDVPLTCIEQIVTVNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSANKINGIPSGDGGGGGGGGNGAGGGSSQKTPLFETYSDWDREIKRTGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHSNGSALVRMALIKDVLQQRKIDQRICNAITKSHPQRSDVYKSDLDKTLPNIQEVQAAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSEKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTEFAISKNIQLGDEKGLKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQNGSVKSFKRTKKSYSSTLRGMPSALKNGIISDQELLPRRNSLILKPKPDPAQQTDSQNSDTEQYFREWFSKPANLHGVILPRVSGTHIKLWKLCYFRWVPEAQISLGGSITAFHKLSLLADEVDVLSRMLRQQRSGPLEACYGELGQSRMYFNASGPHHTDTSGTPEFLSSSFPFSPVGNLCRRSILGTPLSKFLSGAKIWLSTETLANED
Protein: Inner membrane protein YgiZ (Q46867)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Transcriptional activator protein BglJ
- Inner membrane protein YnjI
- Inner membrane protein YnbA
Sequence:
MLKQKIKTIFEALLYIMLTYWLIDSFFAFNKYDWMLESGGNICSIPSVSGEDRILQAMIAAFFLLTPLIILILRKLFMREMFEFWVYVFSLGICLVCGWWLFWGRFIFCY
Protein: Rhomboid-like protein 14, mitochondrial (AtRBL14) (EC 3.4.21.-) (Q8RXW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. May function in the heat-shock response pathway.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Might be neither mitochondrial nor chloroplastic. {ECO:0000305|PubMed:18543065}.
Interaction partners:
- Rhomboid-like protein 16, chloroplastic
- RHOMBOID-like protein 4
- RHOMBOID-like protein 1
- RHOMBOID-like protein 3
- Rhomboid-like protein 17, chloroplastic
- Rhomboid-like protein 18
- Rhomboid-like protein 11, chloroplastic
- Rhomboid-like protein 20
- RHOMBOID-like protein 10, chloroplastic
- RHOMBOID-like protein 9, chloroplastic
Sequence:
MENFGEGRRSGGGMLPLLALSAVAEYYRLPWKPPVTASLLAANTLVYLRPAFIDPVIPHISEVWFNPHLIFKHKDLKRLFLSAFYHVNEPHLVYNMMSLLWKGIKLETSMGSSEFASMVFTLIGMSQGVTLLLAKSLLLLFDYDRAYYNEYAVGFSGVLFAMKVVLNSQAEDYSSVYGILVPTKYAAWAELILVQMFVPNASFLGHLGGILAGIIYLKLKGSYSGSDPVTMAVRGVSRLVTWPLRFLNGMVRSRRRRITGRGRVGRGQTGIAGPGIWRCQSCTYDNSGWLSACEMCGSGRARGNGWSLNQGPALSSSNDLPLDELRRRRVERFS
Protein: Auxin response factor 18 (Q9C5W9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin-responsive protein IAA16
- Auxin-responsive protein IAA17
- Auxin-responsive protein IAA9
- Auxin-responsive protein IAA28
- Auxin-responsive protein IAA10
- Auxin transporter protein 1
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA18
- Auxin-responsive protein IAA8
- Auxin-responsive protein IAA12
Sequence:
MASVEGDDDFGSSSSRSYQDQLYTELWKVCAGPLVEVPRAQERVFYFPQGHMEQLVASTNQGINSEEIPVFDLPPKILCRVLDVTLKAEHETDEVYAQITLQPEEDQSEPTSLDPPIVGPTKQEFHSFVKILTASDTSTHGGFSVLRKHATECLPSLDMTQATPTQELVTRDLHGFEWRFKHIFRGQPRRHLLTTGWSTFVSSKRLVAGDAFVFLRGENGDLRVGVRRLARHQSTMPTSVISSQSMHLGVLATASHAVRTTTIFVVFYKPRISQFIVGVNKYMEAIKHGFSLGTRFRMRFEGEESPERIFTGTIVGSGDLSSQWPASKWRSLQVQWDEPTTVQRPDKVSPWEIEPFLATSPISTPAQQPQSKCKRSRPIEPSVKTPAPPSFLYSLPQSQDSINASLKLFQDPSLERISGGYSSNNSFKPETPPPPTNCSYRLFGFDLTSNSPAPIPQDKQPMDTCGAAKCQEPITPTSMSEQKKQQTSRSRTKVQMQGIAVGRAVDLTLLKSYDELIDELEEMFEIQGQLLARDKWIVVFTDDEGDMMLAGDDPWNEFCKMAKKIFIYSSDEVKKMTTKLKISSSLENEEYGNESFENRSRG
Protein: Interferon C (C1IRX7)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPCQLQGQLVRITHNLLRDMGGNFPLECLQENVFVAFPATAFASSGAPQLSSSGAKAIYETLKNIDILFEADDLPTQWDQQKLENFQNIVYRQIEESKCMMGSVDTSDYLIRTEGLNTYFGNIAAVLKEKNFSYC
Protein: 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2) (Q9YHT4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (By similarity). Contributes significantly to heme formation during erythropoiesis (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22557}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22557}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P22557}.
Interaction partners:
- Delta-aminolevulinic acid dehydratase
- Ferrochelatase
- Threonine aldolase 1
- glycine hydroxymethyltransferase
- Sarcosine dehydrogenase, mitochondrial
- Serine hydroxymethyltransferase
- Alanine--glyoxylate aminotransferase 2
- D-amino-acid oxidase
- Glycine amidinotransferase, mitochondrial
- Alanine--glyoxylate aminotransferase
Sequence:
MSAFLHHCPFLKSSPGPSARKVATYLNLADRCPIIVRQISAKAAQSSEQNGLLPHKEPKRQLATTATQVAVSMSQSCPFVSSKIGLVKASPQVQEDVQPNLENQDTSGLISSLFSGLQSHQSTGPTHLLQDNFNRPTFSYDEFFTQKIVEKKKDHTYRIFKTVNRFAEVFPFAEDYSIAGRLGSQVSVWCSNDYLGMSRHPRVVKAIGDALKKHGAGAGGTRNISGTSNYHVALENELARLHQKDGALVFSSCFVANDSTLFTLAKMLPGCEIYSDMGNHASMIQGIRNSGAKRFIFRHNDASHLEELLSRSDPLTPKIVAFETVHSMDGAICPLEELCDVAHKYGALTFVDEVHAVGLYGAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAGFIFTTSLPPMVLAGALESVRVLKSDEGQALRRAHQRNVKHMRQLLLDAGLPVVNCPSHIIPIRVGNAAKNSEVCDILLEKHNIYVQAINYPTVPRGEELLRLAPSPFHNPIMMNYFAEKLLDVWQEVGLPLNGPAQASCTFCDRPLHFDLMSEWEKSYFGNMEPRYITVAAQ
Protein: Patched domain-containing protein 1 (Q14B62)
Organism: Mus musculus (Mouse)
Function: Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q96NR3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96NR3}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q96NR3}.
Interaction partners:
Sequence:
MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQKANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQKSNSKVKIYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPDVLQEKPAWYRFLLTARFSEETAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTDLPKKNFTDMLRNSFLKTPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREELYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKRKEKKNPENREEIECVEMVDIDSTRVVDQITTV
Protein: Efflux pump membrane transporter (G3XCW2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}.
Interaction partners:
- Resistance-Nodulation-Cell Division
- Multidrug resistance protein MexA
- Outer membrane protein OprM
- Probable Resistance-Nodulation-Cell Division
- Probable Resistance-Nodulation-Cell Division
- Multidrug resistance protein MexB
- Chloramphenicol-sensitive protein RarD
- Probable Resistance-Nodulation-Cell Division
- Protein CyaE
- Probable transcriptional regulator
Sequence:
MARFFIDRPVFAWVISLLIVLAGVLAIRFLPVAQYPDIAPPVVNVSASYPGASAKVVEEAVTAIIEREMNGAPGLLYTKATSSTGQASLTLTFRQGVNADLAAVEVQNRLKIVESRLPESVRRDGIYVEKAADSIQLIVTLTSSSGRYDAMELGEIASSNVLQALRRVEGVGKVETWGAEYAMRIWPDPAKLTSMNLSASDLVNAVRRHNARLTVGDIGNLGVPDSAPISATVKVDDTLVTPEQFGEIPLRIRADGGAIRLRDVARVEFGQSEYGFVSRVNQMTATGLAVKMAPGSNAVATAKRIRATLDELSRYFPEGVSYNIPYDTSAFVEISIRKVVSTLLEAMLLVFAVMYLFMQNFRATLIPTLVVPVALLGTFTVMLGLGFSINVLTMFGMVLAIGILVDDAIIVVENVERLMAEEGLSPHDATVKAMRQISGAIVGITVVLVSVFVPMAFFSGAVGNIYRQFAVTLAVSIGFSAFLALSLTPALCATLLRPIDADHHEKRGFFGWFNRAFLRLTGRYRNAVAGILARPIRWMLVYTLVIGVVALLFVRLPQAFLPEEDQGDFMIMVMQPEGTPMAETMANVGDVERYLAEHEPVAYAYAVGGFSLYGDGTSSAMIFATLKDWSERREASQHVGAIVERINQRFAGLPNRTVYAMNSPPLPDLGSTSGFDFRLQDRGGVGYEALVKARDQLLARAAEDPRLANVMFAGQGEAPQIRLDIDRRKAETLGVSMDEINTTLAVMFGSDYIGDFMHGSQVRKVVVQADGAKRLGIDDIGRLHVRNEQGEMVPLATFAKAAWTLGPPQLTRYNGYPSFNLEGQAAPGYSSGEAMQAMEQLMQGLPEGIAHEWSGQSFEERLSGAQAPALFALSVLIVFLALAALYESWSIPLAVILVVPLGVLGALLGVSLRGLPNDIYFKVGLITIIGLSAKNAILIIEVAKDHYQEGMSLLQATLEAARLRLRPIVMTSLAFGFGVVPLALSSGAGSGAQVAIGTGVLGGIVTATVLAVFLVPLFFLVVGRLFRLRKAPRTGNSPQIPTEQA
Protein: IPT/TIG domain-containing protein (Q54P41)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MRKLSSFILKINVLLVLFISIASSTFTTQQINALNTISSQCGFQWTSLECGATSTSIFLANSIKCDENGDINRIDIDAVSDCGLNNVFDAFPALKILYLHNVDVKNVPITIYQHPVLEQFQSISTYNFKITTDNGLNDWTKMVSLKYLHIQPVVGTMPLLPTSLQNFYYHSDDTAATQARFPFEIFTPNLLTFYLQLQVAPISSVSLQSTLFKNSTSLQTFLLYCNGYSISFSVFYKLPSTLTTLQLFLLNFGANKTMPRIGEVSWDSLQTVTLNNLAIIGTIDPEFFYLPNLRIWYSQNNPNLIGSFTSEFGSRSKLTQLFISNTAFTGALPNDILAGGLNFLDITSTNIGGAAGGELPSSFYCLPKSVFLSTSTSFRILYDQAKFGPMGTCSPTIASITTPISSLDFSIQIRGTMLGAFIPFISISMENVNGAVPLNCQVQQFGTLISCSNPFIYGQGTLTLNVLNDVTPAPSSSISFKYNAPSIASITPVPTIGGTATIYGTNFWIATRTTTDSNNYVRLINKKGTEIECTNVKVINAYQTLTCDLPSGIDGGIFVVSVSGQDNRNQAFTFLYSPPLIKSTSTKLIPTKLESIVTIFGSNFWNDTSMVQVLVQGSIDCPVQSVNHTILTCKFPKTPFILPAGQLDVSVTVNKLSYGAISNLLTMMDPSFCPNNCGSNGYCDGDVGMCICNSNFTGADCSLSTIVSKFEFGENNATITMTPQLNDDAKTTSSMKLYLVSIIENQNEILIDQWKSIPIDQYTTLYQWYGANQKNINVTIRQNQISSSDQFISFPLNSLTYRVDYYSGSSLTVNNPQFLFEFDQYPKECQNLPIIFGNPTGSSVDTRFFTLNTYNVEYFGRFPKVAIVNGQSGNGGVTSNSVGISGLFNKMVTKVNAYDCQSASFELDLTAYSTAVVREPSINSCTSQDGSQNGNTDNKKSENGWKIGVGIGVGIGGAALIVSAFFITRQRVKLSKTQTLLEKKLKEINNNL
Protein: Ubiquitin-fold modifier 1 (Q9CA23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme 5
- Ubiquitin-fold modifier-conjugating enzyme 1
- AT2G34560 protein
- Adenylyltransferase and sulfurtransferase MOCS3
- Ubiquitin-activating enzyme E1 1
- Ubiquitin-activating enzyme E1 2
- At4g19140
- NEDD8-activating enzyme E1 catalytic subunit
- Plant intracellular Ras-group-related LRR protein 2
- E3 UFM1-protein ligase 1 homolog
Sequence:
MATGGKVSFKVTLTSDPKLPFKVFSVPEGAPFTAVLKFAAEEFKVPPQTSAIITNDGIGINPQQSAGNVFLKHGSELRLIPRDRVGAVFVMDP
Protein: Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4) (Q99PU7)
Organism: Mus musculus (Mouse)
Function: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q92560}. Nucleus {ECO:0000269|PubMed:34170818}. Chromosome {ECO:0000269|PubMed:32747411}. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (By similarity). Recruitment to chromatin is dependent on ASXL1/2/3 and recruitment to specific genes on FOXK1/2 (PubMed:32747411). Nuclear localization is redundantly mediated by the importin and transportin systems; TNPO1/transportin-1 is the major mediator of nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q92560, ECO:0000269|PubMed:32747411}.
Interaction partners:
- Polycomb group protein ASXL1
- Putative Polycomb group protein ASXL2
- Host cell factor 1
- BRCA1-associated RING domain protein 1
- Breast cancer type 1 susceptibility protein homolog
- Forkhead box protein K1
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Transcriptional repressor protein YY1
- Lysine-specific histone demethylase 1B
- 26S proteasome non-ATPase regulatory subunit 4
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYETRLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPLGLEAGRTPVASECTQTDGAEEVAGSCPQTTTHSPPSKCKLVVKPPGSSLNGVPPNPAPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRAPQQYSEDEDDYEDEDEDVQNTNPAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSVPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSSQGSQGSSGLEEKEVVEVTESRDKPGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
Protein: Transporter (O45915)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Trypsin-like protease try-5
- Spermatocyte protein spe-27
- Serine/threonine-protein kinase spe-6
- Serine protease inhibitor swm-1
- Spermatocyte protein spe-8
- Zinc transporter zipt-7.1
- CX domain-containing protein
- SPE-12
- Histone H2A
- Spermatogenesis-defective protein spe-17
Sequence:
MASSSDFKQLKQTRTKSEETTRSASNETVNDDNRSTTTEEIIPIKKTSNATAISNIGFKSVTNLALENIGLDTKMEGPTWTSKWEAITATLSFVTCSGNIWFFPYLCGYYGGWFPYQFTFCYVFIAVPLLYLETALGQYASASPLSVFSRMAPAMAGLSAGMCFIMVFRTISLSVWAIYDLTIFTHASQSIWSTSPWESCQESQSGDYCVNYKLSSKCTWIQPGSDKECDEYQEMLIATRGFQQRKSPFMSFVHGLMYKRSITMNDWEPPSVTSIICAVCLWIIIGIISIGGSKVLGRTGIVALTLLLVGTIMLLSYGMSLNDTTNVFTAFFYQSEGYEDKWMWVWSWADAAAHALRALNVGCGGIQKFASLNNFHNKIHRDVLLISIVSFVFYICTGLLSFMFMAEIGRLYYPDLEASERIQLYATPVMIESVISEILTNSSMGSIWVFLFWLTLAACSIQGISSYIWVISSMIVERLNGSRRKYGKALASWHKRAIILAIMSVTGLISSLPFLGNGGINLMSSIETFASYGTIFIAFVEVITVSYVYGFKRFSVNIRAMIGGHGPPNVFWWLNWLVISPILLIVTFGCIVATFGQKKAFNENSIVSDPIGYSLLVMPCIFVILYFLRDEYDRRKNMEPFVVMIRATGDWGPMNPEDRRNAVKFERQLRVRY
Protein: Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (P18433)
Organism: Homo sapiens (Human)
Function: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
Subcellular location: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052}.
Interaction partners:
- Growth factor receptor-bound protein 2
- Tyrosine-protein kinase Fyn
- 6-pyruvoyl tetrahydrobiopterin synthase
- Proto-oncogene tyrosine-protein kinase Src
- Receptor-type tyrosine-protein phosphatase epsilon
- Mitogen-activated protein kinase 1
- Focal adhesion kinase 1
- Mitogen-activated protein kinase 14
Sequence:
MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK
Protein: Down syndrome cell adhesion molecule 1, isoform BA (Q0E9M2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVPQSYTVNVMDESILRGNSAILKCHIPSFVADFIVVDSWVEDEERVIYPQEDIAESDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVAPKVDTRDEFTFARTRMGASKALICPAQSYPMPFFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVAPKIAPFDFGDEPSNFGESASVQCLVTSGDFPVSFAWLFNGREINENVYDVSMVKLGKKISALSIDIVRDHHAGNYTCVAVNRATSVNFTAELVVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV