wanglab/gogpt-training-data huggingface dataset:
Protein: Toxin coregulated pilus biosynthesis protein T (TCP pilus biosynthesis protein TcpT) (P29480)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Involved in the translocation of the TcpA pilin.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Toxin coregulated pilus biosynthesis protein E
- Type IV pilin assembly protein PilC
- Type II secretion system protein F
- MSHA biogenesis protein MshG
- Prepilin leader peptidase/N-methyltransferase
- Toxin coregulated pilus biosynthesis protein R
- Prepilin leader peptidase/N-methyltransferase
- Type II secretion system protein L
- Toxin coregulated pilin
- Toxin coregulated pilus biosynthesis protein S
Sequence:
MSIDIKYLSRIDIDREEFFFKDSRLMCKKFDEEREVLTLLEFDTKFRVNLLKKDKVYKYFLVSDANHKLLIANLVTEQQAKDLSFIEKDIMKIASSATAYGASDIHFIREDRICKIKFRVNGTMIDYREILSSEADALMFVLYNVMATTKETTWNRKLPQDANIILVINEKAYRFRYAHMPLFGEGGKNYHAVVRIIYPSNNFVCTNYQDIGYNEADTDAIARILNTSYGLFIVSGTTGSGKSTSLKKYIELLFFNKYKGKGCFVTVEDPVEYLISGAQQSSIVADNDDKTKNPFADAVRSAMRRDPDVIMIGEIRDKPTVEALSSAVESGHYCLTTIHAGSVVSVLQRLSGLGMKADKIASPGFLAGITSQKLIPELCPSCKVSFVDERYQRAVFSANENGCEACNHSGFKGRLLLLETLVPTVEDLELVASENWVSLYRKYRERRFIKTGKKGLGEGFSIKDKAYYNVLKGKVCHEYFMLHFGQLDHEDENIIYENYLQEV
Protein: N-alpha-acetyltransferase (NAT) (EC 2.3.1.255) (EC 2.3.1.258) (Amino-terminal acetyltransferase) (N-terminal acetyltransferase) (Q980R9)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Displays alpha (N-terminal) acetyltransferase activity. Catalyzes the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. NAT is able to acetylate the alpha-amino group of methionine, alanine and serine N-terminal residue substrates, however it has a preference for Ser-N-terminal substrates.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Coenzyme A biosynthesis bifunctional protein CoaBC
- Large ribosomal subunit protein uL23
Sequence:
MELAEKDKGRDFTLRNARMDDIDQIIKINRLTLPENYPYYFFVEHLKEYGLAFFVAIVDNSVVGYIMPRIEWGFSNIKQLPSLVRKGHVVSIAVLEEYRRKGIATTLLEASMKSMKNDYNAEEIYLEVRVSNYPAIALYEKLNFKKVKVLKGYYADGEDAYLMARPL
Protein: Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) (P09038)
Organism: Homo sapiens (Human)
Function: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
Subcellular location: Secreted {ECO:0000269|PubMed:20230531}. Nucleus {ECO:0000269|PubMed:22321063}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). {ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:22321063}.
Interaction partners:
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 3
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Vascular endothelial growth factor receptor 2
- Syndecan-1
- Fibroblast growth factor-binding protein 1
- Vascular endothelial growth factor receptor 1
- CD44 antigen
Sequence:
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein: Global nitrogen regulator NrpRI (Nitrogen regulatory protein R I) (Q8PXY1)
Organism: Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Function: Plays a major role in nitrogen regulation. Under nitrogen sufficiency, binds to the nifH and the glnk1 promoters, leading to repression of the transcription of the genes.
Interaction partners:
Sequence:
MMDPQIERKLIEIMRVIHESDKPIGARAIADELNNRGYDIGERAVRYHLRILDERGFTRKHGYAGRTLTDLGENEMNDALIGDRFGFVISRIEEMAFRTTYNPETDKGDVVVNISYFDKDDFETVIELISYTAHAGYMISPRVRIFEEDSLEMSLPPGKIGIATVCSVTFDGLLLKAGIPVEPAYGGILQIENKKPARFLDLISYSGTSIDPIKIFMNRTPTSVLEVLEKGEGKILANMRQINSSAYEMTGKILKKAEKVGLAGCITLGEIDEYLLGAPVETGKFGAAVVGGINGICALEETGIEIETNPISTMLDYQTMKEI
Protein: Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) (Q9D1M0)
Organism: Mus musculus (Mouse)
Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:P55735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P55735}; Cytoplasmic side {ECO:0000250|UniProtKB:P55735}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P55735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P55735}; Cytoplasmic side {ECO:0000250|UniProtKB:P55735}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P55735}. Lysosome membrane {ECO:0000250|UniProtKB:P55735}. Note=In interphase, localizes at both sides of the NPC. {ECO:0000250|UniProtKB:P55735}.
Interaction partners:
- Nuclear pore complex protein Nup107
- Protein transport protein Sec31A
- Nuclear pore complex protein Nup160
- SEC24 homolog B, COPII coat complex component)
- Nuclear pore complex protein Nup85
- GATOR2 complex protein MIOS
- Nucleoporin SEH1
- Nucleoporin Nup37
- GATOR2 complex protein WDR59
- Protein transport protein Sec24A
Sequence:
MVSVMNTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQQNEQ
Protein: SHSP domain-containing protein (Q20164)
Organism: Caenorhabditis elegans
Interaction partners:
- SHSP domain-containing protein
- SHSP domain-containing protein
- Heat shock protein Hsp-16.1/Hsp-16.11
- Heat shock protein Hsp-16.48/Hsp-16.49
- Heat shock protein hsp-16.2
Sequence:
MSVAIDHDQTAKWDWPFQKGDGVVKVLDYEDHFEVGLEAHNFLPNEIDVKNIGEFLEIHMAHTTKDDKFGSITRSITRCYRLPKGTDPATIKSKLDGSGILHISGNKKK
Protein: Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor) (P20783)
Organism: Homo sapiens (Human)
Function: Seems to promote the survival of visceral and proprioceptive sensory neurons.
Subcellular location: Secreted.
Interaction partners:
- BDNF/NT-3 growth factors receptor
- NT-3 growth factor receptor
- High affinity nerve growth factor receptor
- Tumor necrosis factor receptor superfamily member 16
- Neurotrophic factor BDNF precursor form
- Glial cell line-derived neurotrophic factor
- Sortilin
- Platelet-derived growth factor receptor alpha
- Beta-nerve growth factor
- Ciliary neurotrophic factor
Sequence:
MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
Protein: Vacuolar protein sorting-associated protein 35A (Protein ZIG SUPPRESSOR 3) (Vesicle protein sorting 35A) (Q7X659)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. Also involved in the efficient sorting of seed storage proteins (Probable). Binds alone to endosomal membranes and is required for recruitment of VPS26 and VPS29 to membrane. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.
Subcellular location: Cytoplasm. Endosome membrane {ECO:0000269|PubMed:23362252}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 26B
- Sorting nexin 2A
- Sorting nexin 2B
- Vacuolar protein sorting-associated protein 26C
- Sorting nexin 1
- Vacuolar protein sorting-associated protein 35B
- Vacuolar protein sorting-associated protein 35C
- Sorting nexin
Sequence:
MIADGSEDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMRAFDELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEILKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPDIGSEYEGDADTVIDAVEFVLLNFTEMNKLWVRMQHQGPAREKERREKERGELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQIVNCRDEIAQYYLIDCIIQVFPDEYHLQTLDVLLGACPQLQASVDIMTVLSRLMERLSNYAALNAEVLPYFLQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLDYADQVLGSCVKQLSGKGKIDDTRATKELVSLLSAPLEKYNDVVTALKLTNYPLVVEYLDTETKRIMATVIVRSIMKNNTLITTAEKVEALFELIKGIINDLDEPQGLEVDEDDFQEEQNSVALLIHMLYNDDPEEMFKIVNVLKKHFLTGGPKRLKFTIPPLVVSTLKLIRRLPVEGDNPFGKEASVTATKIFQFLNQIIEALPNVPSPDLAFRLYLQCAEAADKCDEEPIAYEFFTQAYILYEEEISDSKAQVTALQLIIGTLQRMQVFGVENRDTLTHKATGYAAKLLKKPDQCRAVYACSHLFWLEDRETIQDGERVLLCLKRALKIANSAQQVANTARGSTGSVTLFIEILNKYLYFYEKGVPQITVESVESLIKLIKNEESMPSDPSAESFFATTLEFMEFQKQKEGAIGERYQAIKV
Protein: Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor RDC1 homolog) (RDC-1) (P56485)
Organism: Mus musculus (Mouse)
Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21220100}; Multi-pass membrane protein {ECO:0000269|PubMed:21220100}. Early endosome {ECO:0000250|UniProtKB:P25106}. Recycling endosome {ECO:0000269|PubMed:21220100}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. {ECO:0000250|UniProtKB:P25106}.
Interaction partners:
- Stromal cell-derived factor 1
- Beta-arrestin-2
- C-X-C chemokine receptor type 4
- Pro-adrenomedullin
- C-X-C motif chemokine 10
- Beta-arrestin-1
- C-X-C motif chemokine 2
- Fractalkine
- C-X-C motif chemokine 9
- C-X-C chemokine receptor type 3
Sequence:
MDVHLFDYAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTGTSSYKKKMVRRVVCILVWLLAFFVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAMSASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQNTK
Protein: UDP-glucuronosyltransferase (EC 2.4.1.17) (Q95KM4)
Organism: Macaca mulatta (Rhesus macaque)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}. Microsome membrane {ECO:0000256|ARBA:ARBA00004111}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004111}.
Interaction partners:
Sequence:
MAVESQGRHPLVLGLLLCVLGPVLCHAGKMLLIPVDGSHWLSMLGTIQQLQQRGHEIVVLAPDASLYIGEGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCGPIVAQYLSLPTVFFLNALPCSLESEATQCPNPFSYVPRPLSAHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQNLLSSASVWLLRSDFVKDYPRPIMPNMAFIGGINCLHQSPLSQEFEAYINASGEHGIVVFSLGSMVAEIPEKKAMAIADALGKIPQTVLWRYTGTPPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMHLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVAFIAFKCCAYGYRKCFGKKGRVKKAHKSKTH
Protein: glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) (Q6FUU0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome D complete sequence
- Multifunctional fusion protein
- Glutamine synthetase
- Glutamate synthase
- Acetylornithine aminotransferase, mitochondrial
- NAD-specific glutamate dehydrogenase
- Glutamate dehydrogenase
- Ornithine aminotransferase
- Protein ARG5,6
Sequence:
MSSAEKIAKQARVAGNVLKTISDENRSKILYRIRDALANAKDEIESANKEDLEQARAGGLADSLVKRLDLFKGDKFDVMLQGISDVADLEDPVGKVKMAREIDNGLMLYQVTAPVGVILVIFESRPEVIANITALCIKSGNAGILKGGKESVNTFKAMAKVVNQTIEQYKDETGVPVGAVQLIETRQDVSDLLGQDEYIDLVVPRGSNSLVRQIKDSTKIPVLGHADGICSIYVDRDADLEKAKRIVLDAKTNYPAGCNAMEGLLLNPDFSQWDDVLHHLITEGGVTIHATTDVKEAFLKKLQDSGKLNDDIKAKIVDAKDGDFDKEFLSLDCAVKFIPNTVDAINHINEHSSKHTDAIITESKEDAEKFLKGIDSSGVYWNASTRFADGFRYGFGTEVGISTSKIHARGPVGLDGLVTYQYQIRGDGQVASDYLGAGGNKAFVHKDIDVTNIKL
Protein: Chascon, isoform D (X2JE77)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform C
Sequence:
MVVILLLSPCTCSRSSSSSHAHDHAHDPGHAPSKHHHQYHQYHQHQQHHQNSQHHQQPEQPPSVARSGDSRSSNESSSASTGDTAIPAGYLQLHHQKQNQNQNQKDPQNRQHSDNYPHQPSHSCSTATNTAPLSVFGHGCWMPQQPANAVPKPPRSHGLQWSSSAYPATHATSHQPVIFRVQSSLPNGSFTNATTTTTTTTDYVRHVTRVNFYDIDTSQVEFEPKDDEESNEVTASNCDTEAITKEEEWITKRKTELTTTRQIETRVKRQVKLQDGKVIEDSGPIVSTNTTEDTDKQETETTEKRDLDLPDDLDGNAQLIDVAALQAGAINETQLAQIQEVFGPADGAGKLVKRMVPRPVDGLVRQTDDKRVISHEEIKDYHETEDVQHHGDFTDQTYVNAVRDGVENLEAVLCSPESQRQLVPLGPKVVANRSKSRKTIDSEDTQKRCLAQEDGTLVTESRRTTEHELIVDDELPDPPANGASDDLGLQLQVGEQVTTTAANQRFFRQRDEQHVDVLANGRLQSTEMRYAAETTQMDKDGPTDLERPGDWDSLSDRMRKLRRSQQQQQKEVALLADRKDALTKRPLDFDREEETRKGETMKWLESHFGSESTASNDSRDDEADAEVEPTKKSYFNVTIKSQSHAQSHLATQQHSHPQHISHGHHPQTLPRSAERERERERERERERERERERERDRDRHPLAMTASASQERKAPANSAGGRSKYFQGISNWSERKDPGPPVNHFSSQAFRDDLQETIRRNGLKKKVSGPGSSQGSALAQETVVQPKDSYVSREDILQQKRQSLSSQFLARSMRGSRDALDDLEAIPGPGPGPSMISPRAEEPSHKRVAYGHRGNNGTHINGHALNGVAPTLVNGRGKSYEPPAPPPAAVPPLEFGGGGSQLGQNPRPTVPQRRRAIEKKLGEHSHTHSHSHSHSSHTSHSAHLPVKSQAPMPSQLNQLEPPPDYSPPPRSRSRSSSPQVDYLMTREMPASTMTLSRKQQQRTRFAPTSSYPPATGGTGNLRPPGATSVSTSNLSAMSGGVSTSKSSRMGQVIGNSLRKLVSKIRSASAERKFRMKSAASKSREQSPSPGQDPRGVGPPVTTYQQYNVIDGHIGSHDSEDSNSDNQRRRERERERERERERERERDPLKQESQSRQNFKRAESADPQLQHLEQAISPRQRYYLGEDPYSSTLYGKENHYERRPRQRNMERTDERMERLERLEREDDYYESRAPPPVTAAHTLGRYQKHGQRFSGSTPNLHQQQQDYRSAQTLPRKLHEQRTQRFGNAMEKQPAPGRGSYLSASGQQQQSRGIPHNQNQQNQQNPNPSPSINGNPNPMQAQQGPAKPARTYAKVLNRSKSFNVHGMNGSNDPSPIYIEKLTRNNYQQRQEPSFGYGLGQGPNANYKSNPHLFSGKDNSLKSGLKSPSIVNLISRSQKDLTKIAGNDEDDVGYPEQDKKQLYLRGLHQQAPDLYRVIHGDEDYGSRKYPLQAKYSLDSRSPPSVELNKDTASIVRRSSEVDHQQSHHHNQQHHQHHIQSHQQQNLRRGSGATIIELRHRK
Protein: BRCA1 associated RING domain 1 L homeolog (BRCA1-associated RING domain protein) (Q90X95)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
Sequence:
MLLRVRSGNRPSETAVREELPMMDEPGWERTRDALREMERKLCCSKCMFILKDPVCLGGCEHVFCWTCVNENLGNECPLCNTPAWVRDVQVNRQLDNMIQLCAKLRNLLSMGKTDENKMDLCQDTLLRLNPAQEKQKKKQIKMWFSPRSRKVRCVVEKKEKSQQISSKTLPQMASYEFVSDSPDGEPAQKKPDPKPRKRMKKKLKDINAEWGVDTENEIDEVSNPRKEHKSGKSVSFCSSAVIQHSPEVLVVESSLKNDTPEEISPNWNKCGLDEPMEMQSTSMKEVNCPSPSEQSTTLKTQDKEKKITTVKRKKHSSPIASSKRPRRRSSDTSKPLNDSDIKANSPEKACKTVSPHKPSENSAKDVRIESTQAAKRDTKMCSTPLPCAKQNNSAKLGQKSTAMPISPNNLTNVKRNYKGETMLHLASIKGDIQGVEDLLNSGANPNVKDNAGWTPLHEACNLGHTMVVQLLLQHHALMNTTGYQNDTPLHDAVKNGHIAIVKLLLSHGASRDAVNIFGLQPVDYAETEEMKSVLLETQTERDRLLLHPCLAAPQLSSHQRKEEAVVLIASGLLATQRADLTKLAKMLKASICAEYDSTVTHVIVSDEPVLRTMKCMMGILAGCWTLQFSWVKACLQSCNREPEESYEIPHGPHRARLNGQQMLPQLLDGCHFYFLGCFTEHRKEDLIELVKAAGGQILIRQPKPDSDVTQTINTVAYHAEADSDQRFCTQYIVFDRASKYRPERVRQGKVWFAPSSWIIECITSFQLLPVH
Protein: Meiotically up-regulated gene 103 protein (O13894)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 110 protein
- Meiotic PUF family protein 1
- mRNA export factor crp79
- Meiotic expression up-regulated protein 14
Sequence:
MEQFEIIRESDADPYYFNKNLRLEECEIDGFTSIYKAPPPYSFVAGLSKNTSSNSFVIHKCLPPLQRNNTIRKRKRNPFLADRPYCINSEDMPLSDDRDMLKERHVKSRKLLLKEKGNRFYRRS
Protein: SSN2 (A0A178V4E1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNVTLLVADAVWSNIESTGSVTEEQLSILQLLFGKNLEKATRIIDKRGVKKISGLPSGRSIFQVVGESQKREEYLCFPGDYCGCYSFFYDVVSRGEHQCCKHQLAARLASSLGTYNEIEVSDDHLALMLSKI
Protein: Zinc finger protein 576 (Q9H609)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- AP-4 complex subunit beta-1
Sequence:
MEDPNPEENMKQQDSPKERSPQSPGGNICHLGAPKCTRCLITFADSKFQERHMKREHPADFVAQKLQGVLFICFTCARSFPSSKALITHQRSHGPAAKPTLPVATTTAQPTFPCPDCGKTFGQAVSLRRHRQMHEVRAPPGTFACTECGQDFAQEAGLHQHYIRHARGEL
Protein: Protein Wnt (A0A0G2K3B7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Frizzled-4
- Frizzled-2
- LDL receptor related protein 5
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-1
- NOTUM, palmitoleoyl-protein carboxylesterase
- Low-density lipoprotein receptor-related protein
- Frizzled-3
- Glypican-3
- Frizzled-9
Sequence:
MLLLSPRSALVSVYCPQIFLLLSSGSYLALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGIDECQHQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK
Protein: Cell death-related nuclease 6 (EC 3.1.-.-) (P34508)
Organism: Caenorhabditis elegans
Function: Involved in the degradation of chromosomal DNA. Contributes to cell killing.
Interaction partners:
- Cell-death-related nuclease 7
- Deoxyribonuclease-2
- 3'-5' exonuclease crn-4
- Exosome complex component RRP46 homolog
- Endonuclease G, mitochondrial
- Exosome complex component 10 homolog
- Flap endonuclease 1
Sequence:
MIRQIILIVSLIGISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKVLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTKATAEKATLTVLLIAIITFFK
Protein: Outer capsid protein sigma-1 (Sigma1) (Cell attachment protein) (Hemagglutinin) (P04506)
Organism: Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Function: Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
Subcellular location: Virion {ECO:0000250}. Note=Found in the outer capsid (36 copies). {ECO:0000250}.
Interaction partners:
Sequence:
MDASLITEIRKIVLQLSVSSNGSQSKEIEEIKKQVQVNVDDIRAANIKLDGLGRQIADISNSISTIESRLGEMDNRLVGISSQVTQLSNSVSQNTQSISSLGDRINAVEPRVDSLDTVTSNLTGRTSTLEADVGSLRTELAALTTRVTTEVTRLDGLINSGQNSIGELSTRLSNVETSMVTTAGRGLQKNGNTLNVIVGNGMWFNSSNQLQLDLSGQSKGVGFVGTGMVVKIDTNYFAYNSNGEITLVSQINELPSRVSTLESAKIDSVLPPLTVREASGVRTLSFGYDTSDFTIINSVLSLRSRLTLPTYRYPLELDTANNRVQVADRFGMRTGTWTGQLQYQHPQLSWRANVTLNLMKVDDWLVLSFSQMTTNSIMADGKFVINFVSGLSSGWQTGDTEPSSTIDPLSTTFAAVQFLNNGQRIDAFRIMGVSEWTDGELEIKNYGGTYTGHTQVYWAPWTIMYPCNVR
Protein: Zinc finger and BTB domain-containing protein 38 (Q8NAP3)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication. Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16354688}. Chromosome {ECO:0000269|PubMed:16354688}. Note=Localizes to chromocenters. {ECO:0000269|PubMed:16354688}.
Interaction partners:
- E3 ubiquitin-protein ligase RBBP6
Sequence:
MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLEDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREHDGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGGSFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAPGTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEALKMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHSSQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKTTSHTRGEIPEESNYVADPGGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMSEVFDDASDQDSTDKPWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDCAVGKAPQDKPFEEEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQSPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAALGMHQKKHLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL