wanglab/gogpt-training-data huggingface dataset:
Protein: HTH-type transcriptional activator FasR (Fatty acid synthesis regulator) (O05858)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable transcriptional regulatory protein NarL
- Manganese transport regulator
- Antitoxin ParD1
- Probable transcriptional regulatory protein
Sequence:
MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLLVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSHVPLTRS
Protein: Beta-2-microglobulin (Q91204)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKTVLSVIAFCVFLGFINAKESPPKVQVYSRNPGQHGKDNTLICHVSGFHPPDISIQLLENGVEIPDAKQTDLAFEQGWQFHLTKSVGFTPASGEEYTCRVRHLKNLKTYTWEADM
Protein: Zfyve9 protein (Q6PDX5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIA
Protein: BK channel (F1QYL4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLAVADGNGSYGSSSSRMSNNINFNKNPDSSVSISKMDVIIPFTPDVPCDNNGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCNIKNKEAQKVNNPITIQADGTTKTGNEKEEAPASEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALGIYFIDSSDPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLCSIFISTWLTAAGFIHLVENSGDPWENFQNSQPLSYWECVYLLMVTMSTVGYGDVYARTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVNGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKAGFIAQSCLAQGLSTMLANLFSMRSYIKIEEDTWQKYYLEGVANEMYTEYLSSAFVGLSFPTVCELCYVKLKLLLIAIEYKSEQRESRSRKRILINPGNHVKMQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRIEDEHPSTLSPKKKQRNGGMRNSPNCSPKMMRHDPLLIPGNEQIESMDANVKRYDSTGMFHWCPSKEIEKVILTRSEASMTVLSGHVVVCIFGDVTSALVGLRNLVMPLRASNFHYHELKPIVFVGSLDYLRREWETLHNFPKVFILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDASLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGLVRQASVTTGSNIPIITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALLAEENALRGGYSTPQTLANRDRCRVAQLALYDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLGAPSQCTKRYVITNPPYEFEMVPTDLIFCLMQFDHNAGQSRASLSHSSHSSHSSSKKSSSVHSIPATNRQNRSSKAREARDKQNATRMNRMGPEKRWFTDEAENAYPRNIQIKPMSTHMANQVNQYKSTSSLIPPIREVEDEC
Protein: Disintegrin and metalloproteinase domain-containing protein 21 (ADAM 21) (EC 3.4.24.-) (Q9UKJ8)
Organism: Homo sapiens (Human)
Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 2
- Disintegrin and metalloproteinase domain-containing protein 30
- Disintegrin and metalloproteinase domain-containing protein 20
Sequence:
MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDDRALLEDQLFIPDDCYYHGYVEAAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKINSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYKQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHSSG
Protein: Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (A0A8I5ZPT6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLDDSRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVRRRFVASRTSHRTFFIFCRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
Protein: Acetylornithine deacetylase (EC 3.5.1.16) (N-acetylornithinase) (AO) (Acetylornithinase) (NAO) (P54638)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Bifunctional protein argC
- Probable acetylornithine aminotransferase, mitochondrial
- Arginine biosynthesis bifunctional protein ArgJ
- Aminoacylase-1
- Adenosylhomocysteinase
- Cytoplasmic tRNA 2-thiolation protein 2
Sequence:
MTKPVASYELDEKRFLTLLGKLIGETENLQNRPPALIPIEDNAGRHVIEALTPYLKANGGVLELEQVHCDPVNYPKRGNIIIEYPGTSKGTSSPKTISFVGSHLDVVPADKTAWDRNPFQLIIEGDKLYGRGTTDCLGHVALLTDLFIQLATEKPALKHSIFAVFIVSEENDEIPGIGVDALDHSGKMNPCKNGPVYWVDSADSQPTIGTGGAQTWNLTAHGKNMHSAMPYRTVNSVELVNEALAEIQRRFYIDFKPHPKEAEYKFDCSSTMKPTLWKPIAGSYNTIPGESTICGDIRLTPFYDMKEMRAKVEGYIKDINANITELRNRGPYSKYDVPASEGVEPVKGSVSIEWLGEASAGVACKLDSDGYKALGKATSEILGSLTPVATCGTLPLVRDLQDSGFDIQITGFGKEETYHADNEYALLSDFKNAIKILSRTIDLLEKN
Protein: Molybdenum ABC transporter, ATP-binding protein (Q3Z7C6)
Organism: Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Interaction partners:
- Molybdenum transport system permease
- Molybdenum ABC transporter, periplasmic molybdate-binding protein
- Nickel import system ATP-binding protein NikD
Sequence:
MLEVNIKKKLPGFDLEVAFSADSGIMAMLGPSGSGKTMTLQCVAGLTQVDEGYINLNGEVLLDTSRKIDIRPQVRRVGFVFQNYALFPHLTVRDNIAYGIRHLEKAESDGIITRLMENMHIASLGHRFPSQLSAGQQQRVALARAIAPEPRVLLLDEPFSALDAVVKESLEIELLSLQQFYKGIIILVTHNFAEGYRMSSKMAIYESGRIAQCGDKGKIVGSPANLTVAGLMGFKNLLVGTVSQIIGQDLYLEVPGLSLFKIRLPEQMQLAVGMRLTLGIRSEFVRVSAAAEENSLPGVVSGVINEVASTRCFFSAGANLQYTFEAFLPPPADASLKVGSRLNFCFPTEHLVVVGQAGETAQTGSLAG
Protein: Membrane-bound hydrogenase subunit beta (EC 1.12.7.2) (Q8U0Z7)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Beta subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane thereby conserving the redox energy in a proton gradient.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10852873, ECO:0000269|PubMed:11054105}.
Interaction partners:
- Probable membrane-bound hydrogenase subunit mbhJ
- Membrane-bound hydrogenase subunit alpha
- Mbh13 NADH dehydrogenase subunit
- Mbh14 iron-sulfur protein
- Hydrogenase
- MrpA C-terminal/MbhE domain-containing protein
- Cation:proton antiporter
- MrpA C-terminal/MbhD domain-containing protein
- Mbh8 NADH dehydrogenase subunit-integral membrane protein
- Na+/H+ antiporter MnhB subunit-related protein domain-containing protein
Sequence:
MSKAEMVANKIKERFPNAEVVVKTNKWGRERVWVRISREEYKELMKFIRELDPEAHYSIGIEQDWGDELGFLNHILLFYDEPPGVSLLIDVHAPKDNPVLPDTSDIFPISLQFEREGMEMVGLDFEGAPDKRRLFLPDDFPEGIYPLRTDEKGVPEEMVKNAGHPYLLRREKK
Protein: 8-oxo-dGTP diphosphatase (8-oxo-dGTPase) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase) (Mutator protein MutT) (dGTP pyrophosphohydrolase) (P08337)
Organism: Escherichia coli (strain K12)
Function: Specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to the related monophosphates, thereby cleaning up the nucleotide pools and preventing misincorporation of 8-oxoGua into DNA and RNA. It prevents replicational errors by removing an oxidatively damaged form of guanine (8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP can be inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT may also ensure transcriptional fidelity, removing 8-oxo-GTP from the ribonucleotide triphosphate pool. However, due to the lower efficiency of RNA polymerase 8-oxo-GTP incorporation, MutT is probably not a major contributor to transcriptional fidelity. It also hydrolyzes 8-oxo-dGDP and 8-oxo-GDP to their monophosphate form. In vitro, can also use dGTP, dGDP and other various nucleoside di- and triphosphates, with much lower efficiency. Works cooperatively with MutM and MutY to prevent accumulation in the DNA of oxidized guanine residues.
Interaction partners:
- Adenine DNA glycosylase
- Formamidopyrimidine-DNA glycosylase
- DNA mismatch repair protein MutL
- DNA mismatch repair protein MutH
- DNA polymerase III subunit epsilon
- Endonuclease III lyase)
- DNA helicase II
Sequence:
MKKLQIAVGIIRNENNEIFITRRAADAHMANKLEFPGGKIEMGETPEQAVVRELQEEVGITPQHFSLFEKLEYEFPDRHITLWFWLVERWEGEPWGKEGQPGEWMSLVGLNADDFPPANEPVIAKLKRL
Protein: Coiled-coil domain-containing protein 114 (Zgc:101737) (Q5U3R2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPRGRSAISVLSDSSDLDFDGIAETEMEKLQRQFRITEGDRQAYSIQSQEIIRKQRQEISKLREEQDELLRTLHVLESQSRRSSETQETETIQTLLEQQNMQEDQLEKEKQTQTQLEQEIMNMEKKLVEARREDITTSQSHTSQTRHTQKAIRTLENKLDRALIRFNEQLTKNSQLREELETLRMERVRFQQLLCRLEKVLQDVRKDIGEVINMSTTAYEARVEAQTKMTMMKEKEMKDLAQYSSDVKELERVIAHEHRLKEFMSTKSNERNALDEAQEISRRNEMKEQRKADAGEEKCETLEEVFHRIQTVTGEENLEKLATKFIEVEDRNFALFNYVNEQNTEADRLREEIHQIKEEMEQLRMKGLQQEEENQLALKQVKDLQQECEIQAQQYEAQAEDISKTLDQIKTGIDSVFSKMDCDRALMDDMLGSSSGIRDSNIMTYLSLVEQRTSELLTIQAFIKSKDLEKNYDLKEVAQFLLGQKADVQKQALMVQPHITRHDYEAEDSSLTDEEDRPLTHHELHRHIMMNSVLHKDESLRVGGGKDVKTPKTSTFSSSRQRSLEE
Protein: AT3g04650/F7O18_13 (F7O18.13 protein) (FAD/NAD(P)-binding oxidoreductase family protein) (Q9SR09)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MATSLMSLSSSFLQPLKLKTLAQPRNTDLSTTRKIITTCDSQNNTGKSNPSSRNPNFQKRRNSSKYGTSRRSILKKSFLQEQVTFTARVSDDPHVAIIGGGMAGLVCALNLEARGVQSTVFDTGIHGLGGRLGTRIIEPQGLIFDHAAQFFTADDSRFIKLVDGWLEKGLVREWKGAVGELEIGGSFSQFPSSSPPRYIAANGMRSLADSLLLESQMVNLVRPCWISKLEPLNGMWHLSENGTPRGQFDVIVIAHNGKCANRLLSASGLPLVAKQMKKLDLSSIWALLAAFDDPLPTVNFEGAFVKGVESLSWMGNNSAKLGNGRTPPHCWTFFSTAAYGKQNKVPQENIPTVTAEKVKAGMLQGVEIALGLPEGSLPKPVYTRLQLWGAALPKNTPAVPCIFDPQGRAGICGDWLLGSNLESAAISGAALGNHIAEFLQNGEANPEEFAIGLHDRLSPLAGHDIGQFPGLTSVGEKEEANAYQLL
Protein: Nudix hydrolase 15, mitochondrial (AtNUDT15) (EC 3.6.1.-) (Coenzyme A diphosphatase NUDT15) (Q8GYB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Coenzyme A diphosphatase which mediates the cleavage of oxidized CoA. Can use malonyl-CoA, hexanoyl-CoA, lauroyl-CoA, myristoyl-CoA and palmitoyl-CoA as substrates, but not isobutyryl-CoA or propionyl-CoA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:18815383}.
Interaction partners:
- Nudix hydrolase 19, chloroplastic
- Nudix hydrolase 13, mitochondrial
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- mRNA-decapping enzyme-like protein
- Dephospho-CoA kinase
- Nudix hydrolase 8
- Peroxisomal nicotinamide adenine dinucleotide carrier
- D-aminoacyl-tRNA deacylase
Sequence:
MFLLYRRLPSFARTTTTTLLCKSMEPAITATSSSSFGGGSSRLAALAQQLRQYKPPPSSSFDDSEEMQTDQETAGKVVSQVGFQESIAPLSKDPDRFKPKRAAVLICLFEGDDGDLRVILTKRSSKLSTHSGEVSLPGGKAEEDDKDDGMTATREAEEEIGLDPSLVDVVTSLEPFLSKHLLRVIPVIGILRDKNKFNPIPNPGEVEAVFDAPLEMFLKDENRRSEEREWMGEKYLIHYFDYRTGDKDYMIWGLTAGILIRAASVTYERPPAFIEQCPKFKYPKM
Protein: Ferredoxin-type protein NapH (Ubiquinol--[NapC cytochrome c] reductase NapH subunit) (P33934)
Organism: Escherichia coli (strain K12)
Function: Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:14674886, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:14674886}.
Interaction partners:
- Periplasmic nitrate reductase
- Cytochrome c-type protein NapC
- Ferredoxin-type protein NapG
- Periplasmic nitrate reductase, electron transfer subunit
- Ferredoxin-type protein NapF
- Chaperone NapD
- Heme exporter protein B
- Cytochrome c-type protein TorY
- Cytochrome c biogenesis ATP-binding export protein CcmA
- Cytochrome c-552
Sequence:
MANRKRDAGREALEKKGWWRSHRWLVLRRLCQFFVLGMFLSGPWFGVWILHGNYSSSLLFDTVPLTDPLMTLQSLASGHLPATVALTGAVIITVLYALAGKRLFCSWVCPLNPITDLANWLRRRFDLNQSATIPRHIRYVLLVVILVGSALTGTLIWEWINPVSLMGRSLVMGFGSGALLILALFLFDLLVVEHGWCGHICPVGALYGVLGSKGVITVAATDRQKCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVTSRDCMTCGRCVDVCSEDVFTITTRWSSGAKS
Protein: Eukaryotic translation initiation factor 4 gamma 2 (A0A8I6A9V3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGRNDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEAVVTEYLNSGNANDAVSGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
Protein: Uncharacterized amino-acid permease C584.13 (Q09887)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSIFKKSSNTAPSQHEDVEALASDEADLAALGYKQEFKREFSAWTSFCVSFSVLGLLPSFASTMYYTTGYAGTPAMVWGWLIAMVFVQCVANGMAELCSSMPTSGGLYYAAAVLAPKGWGPFAAWLTGWSNYLVQVTGPPSVAYSFAGMILTLVQLHNPNFETQNYQIFLLAVAAMIAQGFISSMPTKVLAVFNTWGTVLNMLFLAIVMITVLAVAGTKTPRGFNSNHKVWNEFDNQTDWSNGMAMLMSFAGVIWTMSGYDSPFHLSEECSNASVAAPRAIVMTSAFGGIVGWLLNLCIAYTIVDVNAAMNDDLGQPFVVYLRQVCNYKTTVALTSLTVICSFMMGQGCMVAASRVTYSYARDGVFPFSKYLAIVDKRTKTPNVCVWMNVVVGILCCLLIFAGEAAINAIFSVGAIAAFVAFTTPIFLRVFFVKEDEFKRGPWHLGKFSKINGYAACAFVLLMVPILCFPQFRGKDNTPDAMNWTCVVFGGPMLMVLIWWFVSARKWFKGPRLTIGVDDAVSEINVLEGVTKSDDDSISTLKKK
Protein: Spindle assembly checkpoint protein bub3 (Mitotic checkpoint protein bub3) (O42860)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function.
Subcellular location: Nucleus {ECO:0000269|PubMed:15509783, ECO:0000269|PubMed:22521786, ECO:0000269|PubMed:22660415}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15509783, ECO:0000269|PubMed:22521786, ECO:0000269|PubMed:22660415}. Chromosome, centromere {ECO:0000269|PubMed:15509783}. Note=Associates with kinetochores and centromeres during the early stages of mitosis.
Interaction partners:
- Spindle assembly checkpoint serine/threonine-protein kinase bub1
- Mitotic spindle checkpoint component mad3
- Mitotic spindle checkpoint component mad2
- Anaphase-promoting complex subunit 3
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 5
- Outer kinetochore KNL1 complex subunit spc7
- WD repeat-containing protein slp1
- Cell division control protein 16
Sequence:
MNFSKTLLKNSKDGISSVIFSPSVKNELIAGCWDGSLLHYQISENPELLGKYDLSSPILSLEYTDEKTALVGNLDGTVTTLDLNTRNHEFLGNHGKGVSCISKLRLENCFISGSWDKSFRVWDVRVKQPVEGQDIGKKIFASSSRDNILVLGCSERENLVYDIRNLKLPFQRRPSSFKYMTRSVCCNQNFEGFVSSSIEGRTSVEYINPSQEAQSKNFTFKCHRQIQKDYDIVYPVNDLKFHPIHQTLATAGGDGVVAFWDIQVRKRLRVLNPSKINISSISFNVDGSMLAIATCAQEEAAGNIYVHALESNFAAPKLKS
Protein: Thioredoxin family protein (F4JKW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ARM repeat superfamily protein
- B3 domain-containing protein REM2
- Thioredoxin-like protein AAED1, chloroplastic
- At3g10000
- Protein SUPPRESSOR OF QUENCHING 1, chloroplastic
- Cytochrome c-type biogenesis ccda-like chloroplastic protein
- Thioredoxin-like protein HCF164, chloroplastic
- Thiol-disulfide oxidoreductase LTO1
- Probable protein phosphatase 2C 26
- Far-red impaired responsive
Sequence:
MSISVVDSSLCHPTASFPSSMVHSNRFSKRISGNGNWVRERRRLYVKSSNSEGKKEEAAQKSSSNNTSSFLSFLCPLLKVFSGGDPSQQRNHALEVATSSLASVARLPWGSRVSTGSIDNQDVSSNPPLRLQLFEFEACPFCRRVREAMTELDLSVEVYPCPKGSIRHRELVRRSGGKEMFPFLVDPNTETLMYESGDIVKYLFKQYGNGRGPSTGLLESTLFTGWMPTLLRAGRGMSLWDKASTDLPPKMLELFSYENNPYSRLVREALCELELPYVLHNIGEGSTRMKSLLNASGSNKVPFLVDPNTGVQLGDYEKILAYLFKTYSSAAFA
Protein: Polychaetoid, isoform A (Q9VHK3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKFPDYVPNNMLVGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPPTGQSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRPPVQSGGSSGSGGTTPWENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQPTYGGSNGNYGQAPPPQSYPQANGYNGNGHHYNGGSGTGPYIAPHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAFELYRKPQIGATAGHHHNMSEMEPYDERYDDYYNMPPPAAHPSQGHHMQRSRSAPRYPHERPPHAQDPNYYGHYGTSRGHSQPRQQYSQHHQQQYYDDHGLEMGPPPLPPHKKKKSVLKSPLVALKNALLKSTRPLRRMNSMVEPERKPKGLRRQQSMLERGVQRPYYPDEYPTYPAGFEERAHGGQGMMQPHSQDAYYQRGGHYAPQQQEMMNSTYQNLEGEDIYGNIGNTVPRMPHHQDNGYGYDQYDLYANRACIDLERRQAEAAAASGGRNGRRIVRRHSTTTADRGGNPGPPRRPMISPGYEQDPQEIYQTRNGAYMLPDQRRAPSSEVMTRRRFYPGAANEQTEEEPLYQSRREMQREMQRNHLYQSKREMQERISQGKRDMEREFSPQSSSSQSEASNSEAIYQSRREAKESALKTRSQLRDQIYQTRREALDSMAEPIYVSKRGMGRPAPIYETREESILQSRENETDEKKEKECKTEQIQVEINAQPEEQIEDSTLSRSDLQKSSDTVIENPARAPLVQDEVDDDEEEEVQDQRDPAESSADQTEQPTAIENNLHNEGMVEQSQNDSDDVFEAADKVSPLAPPPAPVQPPTPRSGRAPFHISNILKRTAPPPSSPIGDSCTSIETQYTSQASLPVGPPNATSTPFSSSMSLPIAGPVNNQPSANGRFPTLPREPSTSRGFFDSNGGTLADKLWHVSLQIPPGAIPAGVRQEIYFTVSDPRMGQAVGGPPLDMENGETMLSPLVMCGPQGLEFLVPVTLNIPHCAGRTASLGLALKATDSEKNLHTEWDNIDLPSNAAAHTVSVKVDHF
Protein: Baseplate wedge protein gp11 (Gene product 11) (gp11) (P10929)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate. Involved in the tail assembly.
Subcellular location: Virion {ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:15342608, ECO:0000269|PubMed:2403438, ECO:0000269|PubMed:27193680}. Note=Present in 18 copies in the baseplate. {ECO:0000303|PubMed:21129200}.
Interaction partners:
Sequence:
MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPEGVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTYLDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA
Protein: Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) (P0AGB0)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the dephosphorylation of phosphoserine (P-Ser). Also catalyzes the hydrolysis of phosphothreonine (P-Thr).
Interaction partners:
- Phosphoserine aminotransferase
- Serine hydroxymethyltransferase
- L-serine dehydratase 1
- L-serine dehydratase TdcG
- L-serine dehydratase 2
- Histidine biosynthesis bifunctional protein HisIE
- L-threonine dehydratase catabolic TdcB
- Tryptophan synthase beta chain
- L-threonine dehydratase biosynthetic IlvA
- Tryptophan synthase alpha chain
Sequence:
MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRTPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVIGDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKAEVTIRHADLMGVFCILSGSLNQK
Protein: B-cell lymphoma/leukemia 10 isoform X1 (BCL10 immune-signaling adaptor) (E7F8A6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Paracaspase
- MALT paracaspase 3.
- MALT paracaspase 1.
- Caspase 22, apoptosis-related cysteine peptidase
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
- Stress-activated protein kinase JNK
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase
Sequence:
MDVTHLTEDEMADIKKEAIERLRPYLVDKIIADRHFDYLRSKKILTREDTEEISCRTTRGKRTSKLLDILAENPRGLDMLIESIKWGRTLNFIIARITDEVQRVKNERLEALKAGSNSAYPTTKGATNDFSKMDSDYDKYSTMCLHPEGEASSSSSVATGSFNLRYSSTRGNEALMVSGGSGTMNVSSTSSILPKPGDPGAPALPEEMENDEQDMDGGVCKSAGSSGDANFQPLRSRSLSP
Protein: Protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 (AtSKD1) (EC 3.6.4.6) (Protein VACUOLAR PROTEIN SORTING 4) (Q9ZNT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. May also regulate cell cycle. Required during seed development for the formation of mucilage in seed coat and testa. Involved in the maintenance of Na(+)/K(+) homeostasis under salt stress. Required for cell expansion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17468262, ECO:0000269|PubMed:20663085}. Nucleus {ECO:0000269|PubMed:20663085}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:17468262, ECO:0000269|PubMed:20663085, ECO:0000269|PubMed:25010425}; Peripheral membrane protein {ECO:0000269|PubMed:17468262, ECO:0000269|PubMed:20663085}. Prevacuolar compartment membrane {ECO:0000250|UniProtKB:P46467}; Peripheral membrane protein {ECO:0000250|UniProtKB:P46467}. Note=In young trichome vacuole-free cells, present in the cytosol and in the nucleus. In vacuole-containing cells, present in punctae and large speckles corresponding to prevacuolar compartments (PubMed:20663085). Localized in multivesicular body when associated with LIP5 (PubMed:25010425). {ECO:0000269|PubMed:20663085, ECO:0000269|PubMed:25010425}.
Interaction partners:
- Protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5
- ESCRT-related protein CHMP1B
- ESCRT-related protein CHMP1A
- Vacuolar protein sorting-associated protein 60.1
- Vacuolar protein sorting-associated protein 60.2
- Vacuolar protein sorting-associated protein 32 homolog 1
- Vacuolar protein sorting-associated protein 32 homolog 2
- Vacuolar protein sorting-associated protein 2 homolog 1
- Vacuolar protein sorting-associated protein 24 homolog 1
- Vacuolar-sorting protein BRO1
Sequence:
MYSNFKEQAIEYVKQAVHEDNAGNYNKAFPLYMNALEYFKTHLKYEKNPKIREAITQKFTEYLRRAEEIRAVLDEGGSGPGSNGDAAVATRPKTKPKDGEGGGKDGEDPEQSKLRAGLNSAIVREKPNIKWSDVAGLESAKQALQEAVILPVKFPQFFTGKRRPWRAFLLYGPPGTGKSYLAKAVATEADSTFFSVSSSDLVSKWMGESEKLVSNLFEMARESAPSIIFVDEIDSLCGTRGEGNESEASRRIKTELLVQMQGVGHNDEKVLVLAATNTPYALDQAIRRRFDKRIYIPLPEAKARQHMFKVHLGDTPHNLTEPDFEYLGQKTEGFSGSDVSVCVKDVLFEPVRKTQDAMFFFKSPDGTWMPCGPRHPGAIQTTMQDLATKGLAEKIIPPPITRTDFEKVLARQRPTVSKSDLDVHERFTQEFGEEG