wanglab/gogpt-training-data huggingface dataset:
Protein: Neuronal acetylcholine receptor subunit alpha-2 (Q91X60)
Organism: Mus musculus (Mouse)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:Q15822}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q15822}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuronal acetylcholine receptor subunit beta-3
- Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-7
- Neuronal acetylcholine receptor subunit alpha-4
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit gamma
- Acetylcholine receptor subunit delta
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit alpha-6
- Neuronal acetylcholine receptor subunit alpha-5
Sequence:
MAPSHPAFQFWIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPGLKLSPTYHWLETNMDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Protein: Nuclear export protein (NEP) (Non-structural protein 2) (NS2) (P03508)
Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Function: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04067}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04067}.
Interaction partners:
Sequence:
MDPNTVSSFQDILLRMSKMQLESSSGDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNEKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALHLLLEVEQEIRTFSFQLI
Protein: CcsA (C5MRI9)
Organism: Oryza sativa (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLFATLEHILTHISFSTISIVITIHLITLLVRELGGLRDSSEKGMIATFFCITGFLVSRWASSGHFPLSNLYESLIFLSWALYILHMIPKIQNSKNDLSTITTPSTILTQGFATSGLLTEMHQSTILVPALQSQWLMMHVSMMLLSYATLLCGSLLSAALLMIRFRKNLDFFSKKKKNVLSKTFFFNEIEYFYAKRSALKSTFFPLFPNYYKYQLIERLDSWSYRVISLGFTLLT
Protein: Dof zinc finger protein DOF4.7 (AtDOF4.7) (Protein DNA BINDING WITH ONE FINGER 4.7) (Q84K52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Involved in the negative regulation of floral organ abscission by binding to the typical DOF 5'-AAAG-3' sequences in the promoter of ADPG2/PGAZAT, and by down-regulating its expression. ADPG2/PGAZAT is an abscission-related and cell wall hydrolyzing polygalacturonase. May act through the interaction with ZFP2, an abscission-related transcription factor.
Subcellular location: Nucleus {ECO:0000269|PubMed:20466844}.
Interaction partners:
- Polygalacturonase ADPG2
- F14D16.11
- Polygalacturonase 1 beta-like protein 3
- Small ribosomal subunit protein eS12z
- Protein IDA
Sequence:
MMTSSHQSNTTGFKPRRIKTTAKPPRQINNKEPSPATQPVLKCPRCDSVNTKFCYYNNYSLSQPRHYCKNCRRYWTRGGALRNVPIGGSTRNKNKPCSLQVISSPPLFSNGTSSASRELVRNHPSTAMMMMSSGGFSGYMFPLDPNFNLASSSIESLSSFNQDLHQKLQQQRLVTSMFLQDSLPVNEKTVMFQNVELIPPSTVTTDWVFDRFATGGGATSGNHEDNDDGEGNLGNWFHNANNNALL
Protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4) (Q9BTN0)
Organism: Homo sapiens (Human)
Function: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase F
- Flotillin-1
- Disks large homolog 4
- Receptor-type tyrosine-protein phosphatase S
- Flotillin-2
Sequence:
MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKVADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEPAALRAHTVVQLDCEPWGPGHEPVGP
Protein: Stimulated by retinoic acid gene 8 protein homolog (Q7Z7C7)
Organism: Homo sapiens (Human)
Function: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. {ECO:0000250|UniProtKB:P70278}.
Interaction partners:
- Nanos homolog 2
- Cytochrome P450 26B1
- Deleted in azoospermia-like
- Synaptonemal complex protein 3
- Transcription initiation factor TFIID subunit 4B
- Cytochrome P450 26C1
- Zinc finger and BTB domain-containing protein 16
- Cytochrome P450 26A1
- Meiotic recombination protein REC8 homolog
- Meiosis initiator protein
Sequence:
MGKIDVDKILFFNQEIRLWQLIMATPEENSNPHDRATPQLPAQLQELEHRVARRRLSQARHRATLAALFNNLRKTVYSQSDLIASKWQVLNKAKSHIPELEQTLDNLLKLKASFNLEDGHASSLEEVKKEYASMYSGNDSFPQNGSSPWYLNFYKQTMDLLTGSGIITPQEAALPIVSAAISHLWQNLSEERKASLRQAWAQKHRGPATLAEACREPACAEGSVKDSGVDSQGASCSLVSTPEEILFEDAFDVASFLDKSEVPSTSSSSSVLASCNPENPEEKFQLYMQIINFFKGLSCANTQVKQEASFPVDEEMIMLQCTETFDDEDL
Protein: Proton-coupled zinc antiporter SLC30A2 (Solute carrier family 30 member 2) (Zinc transporter 2) (ZnT-2) (Q2HJ10)
Organism: Mus musculus (Mouse)
Function: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity. Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (Probable). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (By similarity).
Subcellular location: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000269|PubMed:20133611}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000305|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9BRI3}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:21289295}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is induced by TNF-alpha. {ECO:0000250|UniProtKB:Q9BRI3}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Zinc transporter ZIP13
- Zinc transporter 6
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP4
- Zinc transporter ZIP12
- Zinc transporter ZIP5
- Zinc transporter SLC39A7
- V-type proton ATPase subunit d 2
- Zinc transporter ZIP10
- Zinc transporter ZIP1
Sequence:
MQTMDKQNLLESTRGARSFLGSLWKSEASRIPPVDLPAVELAVQSNHYCHAQKDSGSHPDPEKQRARRKLYVASAICLVFMIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQRLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHSHGNSRDDSSQQQNPSVRAAFIHVIGDLLQSVGVLVAAYIIYFKPEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVHIAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIEKYSEDMKNCQACQGPLE
Protein: Propionyl-CoA carboxylase beta chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta) (Q8T131)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- propionyl-CoA carboxylase
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Methylmalonyl-CoA epimerase, mitochondrial
- acetyl-CoA C-acyltransferase
- Peroxisomal acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Sequence:
MLSRRLLNKNTIQFLNKNCKNVSSQGIKSFATGKPTPAKEPFKAVKYESTIERINGRIQEETERAQLGGGVKKIDVQHGKGKLLARERLDLLLDDGSFREYDMLVTHRCTDFNVEKTPGDGVVTGHGTINGKLVFVFSQDSTVNGGSLSEAHAEKICKIMDKAMLVGAPVIGLNDSGGARIQEGIASLAGYAEVFQRNVMASGVIPQISVIMGPCAGGAVYSPAITDYVFMVKDTSYLFVTGPDVVKSVTNQEISQEGLGGAKIHTTKSGVAHLAFDNDIDALKRVREFVTLLPSNPNEPAMREAFDSPSREDDVLDQIIPDDPNKPYDMKEVIERIVDEGEFFEIQPEFAKNIIVGYARMEGRTVGFVANQPKELAGCLDIDASVKAARFVRFCDCFNIPIVTLIDVPGFLPGTNQEHNGIIRHGAKLLYAYAEATVPKISIITRKAYGGAYDVMSSKHLRGDTNYSWPTGQIAVMGSKGAVEIIFRGKGDIKEQEQIYNDKFANPLPAARRGFIDDIIPPRMSRQYICEDLEILKNKKLSNPTKKHGNIVL
Protein: Seipin homolog (O14119)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000255}. Note=Concentrates at endoplasmic reticulum lipid droplet junctions. {ECO:0000250|UniProtKB:Q06058}.
Interaction partners:
- Protein bem46
- Nucleus-vacuole junction protein 2
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- UDP-N-acetylglucosamine transporter yea4
Sequence:
MGYLVKLFKLVVWMLVIGLFSIPSLVSYVIFYDTVIPHSVIQYPVYFNYTTGLNFPTAEVRLDHFSIDPRLPGTSLLQIKMPHSPRNSAMGNFMVSVDFQDRNQRSLKQVKRTVLLPHRSPIHEYLKLIVCSPLYFMGILEETDIVNVRLFESETFAKSFNSITTLSVRFSVKNTPAQAIVKIYSKDIEFYEATLAFASKLHGMRWFMYTHKVSAFLVFTSLFWFTGITSTIITYLIVSSTSETKATRR
Protein: Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B) (Q14525)
Organism: Homo sapiens (Human)
Interaction partners:
- Keratin-associated protein 3-1
- Keratin, type I cuticular Ha4
- Keratin-associated protein 1-3
- Keratin-associated protein 1-1
- Keratin-associated protein 9-3
- Keratin-associated protein 11-1
- Keratin-associated protein 3-2
- Keratin-associated protein 17-1
- Keratin, type I cuticular Ha5
- Keratin, type I cuticular Ha3-I
Sequence:
MPYNFCLPSLSCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCRSDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLPSNPCATTNACEKPIGSCVTNPCGPRSRCGPCNTFGY
Protein: Late embryogenesis abundant protein 47 (LEA 47) (Q8GWT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: LEA proteins are late embryonic proteins abundant in higher plant seed embryos. The function of those proteins is not known.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25005920}. Nucleus {ECO:0000269|PubMed:25005920}.
Interaction partners:
- Pre-mRNA-splicing factor SLU7-B
- Late embryogenesis abundant domain-containing protein / LEA domain-containing protein
- Late embryogenis abundant protein 2
Sequence:
MSEEQLQKPIDCADVKGEAEKISTTEGGIKAAEDKEKGVVAEASGEQAEGEVNQKKVVANPLKSEGTITIGEALEAAVLTAGNKPVEWSDAAAIQAAEVRATGRTNIMPGGVAASAQSAATLNARIGSDDTKTTLADVLTGASSKLPSDKAATRKDAEGVTGAEMRNDPHLTTYPTGVAASVAAAARINQSK
Protein: Myosin Ic, paralog b (A0A286Y9H2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, stereocilium membrane {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDLSNLGDLMKKTQSSIVEKSFAFKNTDAVVNAVGSDGIRVMMESALTARDRVGVQDFVLLENHTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDLEIYTKQHMERYRGVNFYEVSPHIYAVADNAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAVTCPASDHVQTVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSRVVHQSNGERNFHIFYQLIEGGEDDLLRRLGLERNAQQYQYLVKGNCPKVSSINDRNDWKTVRKALSVIGFTDDEVEELLNIIASVLHLGNVQYGGEDSGSAYITTDTQIKYLARLLGVDGTVLKEALTHKKIIAKGEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKNASVIGLLDIYGFEVFQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGDASDITFLEKLENTVGGHAHFLTHKLADGKTRKVMGREEFRLIHYAGEVNYNVKGFLDKNNDLLFRNLKQVMCMSENKILNQCFDREELSDKKRPETAATQFKNSLAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRRYETFLQRYKSLCPDTWPNWDGRQVDGVSTLVKHLGYKPEEYKLGRTKIFIRFPKTLFATEDALEVRKHSLATQLQSSWKGYSQKTKYQKMRHSAVWIQAWWRGILARRAAKRRREAADTIRRFIKGFIYRHQPRCPENEYFLDYVRYSFLMNLHRCQPKTVLDKSWPTPPPALVEASQHLRKLCMQNMVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYPQSVPKLFVNTRLNGEDINPKVLQALGNEKMKYAVPVIKYDRKGYKARNRQLLLMSDSAVIVEEGKLKQRIDYNSLKGISVSSLSDGMFVFHVASEDNKQKGDVVLQNEHVIETLTKVAICADKMDDININQGSIKFDVAQGKEGIIDFTAGSELLIVKAKNGHLSVTAPRLNSR
Protein: Alpha-catulin (H2L011)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Dystrobrevin-1
- Dystrophin-1
- FERM domain-containing protein
- Calcium-activated potassium channel slo-1
- Syntrophin-1
- OOcyte Partner of Spe-11
- Vinculin
- Interactor with SLO-1
Sequence:
MKIPGRRGGHLAKKMAASSMSSLTSSYHTTAMPSSNSVVPPFDARNLEIKTKSIEQTLIPLVTQITTLVNYKESYMASGKPKSERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDPNSVVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSFNDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCDSALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTANAAIKQLTEMLEMIRMTVRVGAGVRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEMTNLIQPDENEQLAASGLEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANEDQVLLSSMKACAVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLCVHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAANGRVAAEKQAYMSLPRPGKHGTTQKPSKPITLDVEDQQKMAKVGLEMKLLTSEVDAEAEKWDEYAENDIVKRAKAMSSMAYNMYLFTRGDGPLKTTHDLFTQAEFFAEQANQMYRTVREFSYEVPGSAEKSDLSAILERIPLHCQQLQVMVKSPTVGKTATFGKVDSVIQETKNLMNEIAKLVTASFVCATKMFQDSQQGMKSSFAEVLSMGGRVPTVKGQVANRLFGAGHQASDEPRRRPLRTFPPTTHQAYTFSSTIAS
Protein: Cation channel sperm-associated targeting subunit tau (CatSper-tau) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein) (C2 calcium-dependent domain-containing protein 6) (Q53TS8)
Organism: Homo sapiens (Human)
Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CatSper complex targeting and trafficking into the quadrilinear nanodomains. Targets the preassembled CatSper complexes to elongating flagella, where it links the channel-carrying vesicles and motor proteins.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:E9Q9F6}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250|UniProtKB:E9Q9F6}.
Interaction partners:
Sequence:
MEPPQETNRPFSTLDNRSGQVQVLSATPLLQRNPYSSPDIMHIKGSEASSVPYALNQGTTALPKNKNQEGTGHRLLNMLRKTLKESDSEELEITQETPNLVPFGDVVGCLGIHIKNCRHFMPKISLQHYANLFIRISINKAVKCTKMCSLLSKNDEKNTVIKFDEVKYFSVQVPRRYDDKRNNILLELIQYDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHGNIFVCRLEVEFMFSYGNFGYGFSHQLKPLQKITEPSMFMNLAPPPERTDPVTKVITPQTVEYPAFLSPDLNVTVGTPAVQSSNQPSVVRLEKLQQQPRERLEKMKKEYRNLNTWIDKANYLESILMPKLEHKDSEETNIDEASENTKSNHPEEELENIVGVDIPLVNEEAETTANELLDNDSEKGLTIPTLNQSDQDNSTADASKNDESTPSPTEVHSLCTISNQETIKAGRIPPLGERQSESMPDRKMKNVFFPLEVKLKDNYPSILKADSSLSEVAFSPKEYNSPSFRPEYIEFKPKFQFQKFNKNGFDPFLRNINKMSVRKRKDQDIYKYRNILGAEVIEHEDQDPPYPAQSKTAGPANTTWAHDPNIFTTKMLETENKLAPDPTINTIKGLDTKNSLKENLPNVSLPSIKGESSRAGNVQANTCHLSKSLNFTPHIEYLKQSMILKSILSENLQDLSDKLFSKPEVSMNSEAREKSSSPLLSIHDKSSSSMEDNVLEKKQDLNNWLSEKDILNSKTTLSQIIKNIPADSFSEGSQIIENIPADSLLEGGQVIKNIPEYSLSEGGQIIKNIPADSFLESGPGQSPEVEEHVSKKHFEADERDFPIKKNSSTKKKHLISEVPNSKSGSSGTVHDYIMRQIFTAPIFSELEIEVKEPSETPMNLENQLPTPWKRSLSSHILFHEENADEIELPQPRSATSQIIQAFPIDTLLESGIIKVIELDKEHHKSSLLGTGITSPKGNLKDSQEYYSEIRSETEPLSEQSIPIIPKDTTSVSRAEFIQEDQNMFPQDSSYYSIANKELYLPRNGQRLCKDKNDLSSTLESLTNSLMDKLSESDEIMLKSFLKNIFNVFFKYNHSERRGQPEKELERLIQPSFTSDTEHLEELQEDFDKADKLDRKPILSPKLRVFLEELSESEVKHLKSELSKQIQHYLVERLSESGHITKEDLPKIYQNLYLMNEKAEQKGPNSFQGKYSETVKEIMSFVNNFNHHFIDKHLEIKLRSFLKEILQNYFLKNISESSLFNETASETIYPNISSLRTKSVSISFHELEQDISKGSFGRRFEINMKYPLSKSLQNYLIALSENELLHLKADLSKHLQSLFIEKLSKSGLMTKKQLEGINQHINLLNSSSIPLKYIKTHLPFRDDCHFVEKHSEKQNKYSRIVQQTTLQTVSEDKLREAELIREKEKKYFPLQNLKGNSSLIKEQKSYYTKEEAKTPSLIKVQPSSNENIQASPLSKSSEILTDILLKKLRKEHVFTQLPQAENSVHKTEIQDPYSWGGKSKITQSKAWCEKTLKMKSLDRKEHVNIYKWTVQEKPEAVLTSYPRIPNARMPREDEYLNRITFPSWQSSTLTHFNTETGEKSKLEDQYCQTLKGNNNNNKKHLVTFAQYKKEIQTLYIKPDEICSEKCAKFPEIQSFQYKVVEDEKNLKPHLFPELFKIEDLKPKVRKERDRVAQPKKSFNKIVRILPTTLPTTRIHLKKSVPRTLLHWTARRTIHDCSDKFEDLHDMTSFTHLKKVKSRSRLLGKSSDDIHNHARHSARPYTAPEVNKQRESYSGKFTSRRMVSSGLVHINDKTSDYEMHKMRPKKIKRGY
Protein: Mediator of replication checkpoint protein 1 (DNA replication checkpoint mediator MRC1) (P25588)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for normal DNA replication. Phosphorylated in response to DNA replication stress. Phosphorylation allows it to mediate the activation of RAD53.
Subcellular location: Nucleus {ECO:0000269|PubMed:12865299}. Note=Associated with chromatin during S phase.
Interaction partners:
- Serine/threonine-protein kinase RAD53
- Topoisomerase 1-associated factor 1
- DNA polymerase alpha-binding protein
- Chromosome segregation in meiosis protein 3
- DNA replication licensing factor MCM2
- Serine/threonine-protein kinase MEC1
- Cell division control protein 45
- DNA replication licensing factor MCM4
- DNA repair protein RAD9
- DNA replication licensing factor MCM6
Sequence:
MDDALHALSSLTAKKRTTTYKKVAVPILDENDNTNGNGPNDIDNPPELTGNGFLFANATLNRVKNRLEGKKAPEQNHNNGKDRSENSLPTQLISNLYDGGEELEKSEVKDNSYSEKNVSSSFTQTQRIPVSIQQDKVFNVPIHSVNDGKPTQLIKEDGLVNETSQALKTPLTTGRPGATQRIDSSGATSQTQPIKSIEPQSQIITTSSNHSNALSPKIPIIPTELIGTSPLFQSIQNRGPDTQMDVPPQTAHDEDKTQAIGIPQATHQEQKTQIDTVAQTLQDEVPHTLKIREIQSELASEDSKREKARNVEYKKPQKPIPTKKFFSKESFLADFDDSSSNEDDDIKLENAHPKPVQNDDELHENKSVELNLTDETRINEKRVPLLSSYANNLKREIDSSKCITLDLDSDSDEYGDDDMDSIKLSKDESVLPISQLSKATILNLKARLSKQNQKLSQRPNKSKDPKVDHNVLLNTLRKASRKQILDHQKEVIETKGLKLEDMAKEKEIVENLLEQEILRNKRIRQKEKRREKLEENDFQLNAHDSGSDSGSESSGFALSGNEIADYESSGSENDNRRESDSEKEDDEIILKQKKSHHVKHIINESDSDTEVEAKPKEKADESLPKRIAINLGHYGDNIGEDTDKFQETNVLDTQNIEEVMAERNTIENEVKDDVYVNEEADEAIRRQLIDKEKLQLKQKEKEHEAKIKELKKRGVTNFFEMEAEESEDEWHGIGGADGEGSDDYDSDLEKMIDDYSKNNFNPHEIREMLAAENKEMDIKMINKILYDIKNGGFRNKRAKNSLELELSDDDEDDVLQQYRLKRRELMRKRRLEIGDDAKLVKNPKSSAFFESMVEDIIEYKNPFGAEEEYNLDITSTATDLDTQDNSINVGDNTGNNEQKPVDQKNKKVIISEDFVQKSLSFLKSNNYEDFETDKELSRIQHGNDEAIEDLYTLKQNSSIKSFTNSQTDSTTSKTVNTIIDLEKRPEDEDEVENGDTSLVGVFKHPSIIKSFASRTDINDKFKEGNKTVKILKSYKTVGSSKASITYMGKTRKLIAPKRKTEGSHRYHHDHHNKKMKMKTKTKSNKLFESGQDSFDN
Protein: At4g27580 (Phosphatidylinositol transfer SFH5-like protein) (Q8L9A7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized mitochondrial protein AtMg00030
- Uncharacterized mitochondrial protein AtMg01130
- Polynucleotidyl transferase, ribonuclease H-like superfamily protein
- Methionyl-tRNA synthetase
- Uncharacterized mitochondrial protein AtMg01330
- Pentatricopeptide repeat-containing protein At3g24000
- Uncharacterized mitochondrial protein AtMg00660
- Uncharacterized mitochondrial protein AtMg01200
- Uncharacterized mitochondrial protein AtMg00670
- Small ribosomal subunit protein uS3m
Sequence:
MGACASKPKESDIVEGSVSTENAVVESKNAATETDATLTQEKKEESIEETKKEGETKEDSSEATKAEPTPEAVKAEEKTSSETEPPAQETTPAAKTDEAPLVIL
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (H3BTA2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKP
Protein: Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) (O75828)
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18493841}.
Interaction partners:
- Carbonyl reductase 1])
- Cytochrome P450 3A4)
- Cytochrome P450 2D6
- Cytochrome P450 1A1
- Cytochrome P450 2E1
- Aldo-keto reductase family 1 member A1
- Prostaglandin E synthase 3
- Cytochrome P450 2A13
- Cytochrome P450 2A6
- Prostaglandin E synthase 2
Sequence:
MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
Protein: Pentatricopeptide repeat-containing protein At1g62260, mitochondrial (O04590)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Retrotransposon ORF-1 protein
- Phosphoglycerate mutase family protein
- Retrotransposon ORF-1 protein
- Retrotransposon ORF-1 protein
- NADH dehydrogenase subunit 7
- NADH dehydrogenase iron-sulfur protein 2
- Transmembrane 9 superfamily member 6
- Transmembrane 9 superfamily member 7
Sequence:
MIRSRSVLLIFRKVLYQSSCLKCLLCANSFSTSVSSSLGFRATNKELNQMIRSGYIAEARDIFEKLEARNTVTWNTMISGYVKRREMNQARKLFDVMPKRDVVTWNTMISGYVSCGGIRFLEEARKLFDEMPSRDSFSWNTMISGYAKNRRIGEALLLFEKMPERNAVSWSAMITGFCQNGEVDSAVVLFRKMPVKDSSPLCALVAGLIKNERLSEAAWVLGQYGSLVSGREDLVYAYNTLIVGYGQRGQVEAARCLFDQIPDLCGDDHGGEFRERFCKNVVSWNSMIKAYLKVGDVVSARLLFDQMKDRDTISWNTMIDGYVHVSRMEDAFALFSEMPNRDAHSWNMMVSGYASVGNVELARHYFEKTPEKHTVSWNSIIAAYEKNKDYKEAVDLFIRMNIEGEKPDPHTLTSLLSASTGLVNLRLGMQMHQIVVKTVIPDVPVHNALITMYSRCGEIMESRRIFDEMKLKREVITWNAMIGGYAFHGNASEALNLFGSMKSNGIYPSHITFVSVLNACAHAGLVDEAKAQFVSMMSVYKIEPQMEHYSSLVNVTSGQGQFEEAMYIITSMPFEPDKTVWGALLDACRIYNNVGLAHVAAEAMSRLEPESSTPYVLLYNMYADMGLWDEASQVRMNMESKRIKKERGSSWVDSST