wanglab/gogpt-training-data huggingface dataset:
Protein: Lignostilbene-alpha,beta-dioxygenase isozyme III (LSD-III) (EC 1.13.11.43) (Q52008)
Organism: Sphingomonas paucimobilis (Pseudomonas paucimobilis)
Function: Catalyzes the cleavage of the interphenyl double bond (C alpha-C beta) of lignin-derived polyphenolic diaryl-propane type compounds (Stilbene).
Interaction partners:
Sequence:
MAHFPDTSGMTGVLRPLRIEGDILDLEVEGEIPAQLDGTFHRVHPDAQFPPRFEDDQFFNGDGMVSLFRFHDGKIDFRQRYAQTDKWKVERKAGKSLFGAYRNPLTDDASVQGMIRGTANTNVMVHAGKLYAMKEDSPCLIMDPLTLETEGYTNFDGKLKNQTFSAHAKIDPVTGNFCNFGYAATGLLTTDCSYFEIDPAGNLLFETEFQVPYYCMMHDYGLTEHYAIFHIVPCSPNWDRLKAGLPHFGFDTTLPVWLGVVPRGPGVTNKDVRWFKAPKTIFASHVMNAFEEGSKIHFDTPQAENNAFPFFPDIHGAPFDPVAARPYLHRWTVDLGSNSEDFAEVRQLTSWIDEFPRVDARYVGQPYRHGWGLVMDPEMEMEFARGRASGFKMNRIGHWDHATGKEDSWWCGPQSIIQEPCFVPRMADSAEGDGYIIALVDNLITNYSDLVVLDALNLKDGPIGRAKLPIRLRSGLHGNWADASKLPIAA
Protein: Histone acetyltransferase (EC 2.3.1.48) (A0A8J8YC15)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR003048}.
Interaction partners:
Sequence:
MAEAGGVGPPALPPAPPHGSPRTLATAAGSSASCGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRGDLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPMVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPSKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTKVFGRTLLRSVFTIMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSPLGIQTVISPPVTGTALFSSNSTSHEQINGGRTSPGCRSSSGLEANPGEKRKMNNSHAPEEAKRSRVMGDIPVELISEVMSTITDPAGMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKMLMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPKDPEQLYSTLKNILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASVLEKFFFSKIKEAGLMDK
Protein: Autophagy-related protein (Q8IJK2)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Autophagy-related protein 7, putative
- Cysteine protease ATG4, putative
- Autophagy-related protein 3, putative
- Autophagy-related protein 3, putative
- Autophagy-related protein 3, putative
- Ubiquitin-like protein ATG12
- ubiquitinyl hydrolase 1
- DNA polymerase
- Serine/threonine-protein phosphatase
- Aspartyl aminopeptidase
Sequence:
MPSLKDEVSFENRVAETHKIRSKYPNRIPVVCERANRSNLPIIEKKKFLVPMNMLVGEFKFILHQHINQSAYGSNMKLFRERTIYLFVNNIVPKTGLLMQDLYEMYKDEDGYLYMEYSCESCLG
Protein: DNA endonuclease RBBP8 (F6Q6H0)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNISGSSCGSPNSADTSSDFKDLWTKLKECHDREVQGLQVKVTKLKQERILDAQRLEEFFTKNQQLREQQKVLHETIKVLEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEE
Protein: LOB domain-containing protein 12 (ASYMMETRIC LEAVES 2-like protein 5) (AS2-like protein 5) (Q8LBW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- LOB domain-containing protein 40
Sequence:
MGGPGSSPCASCKLLRRRCAKDCIFAPYFPPDDPHKFAIVHKVFGASNVSKMLQELPVHQRADAVNSLVFEANARVRDPVYGCVGAISYLQNQVSQLQMQLAVAQAEILCIQMQNEPTLQSHHQVLELDQDHKALLLNNNNINNCNTNNNNNNFGYAMSSGQFNSNFASPSSIMQMQMQMQMQDPLKQESLWT
Protein: Testis tissue sperm-binding protein Li 50e (A0A140VKD3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
Protein: Olfactory receptor 7C2 (Olfactory receptor 19-18) (OR19-18) (Olfactory receptor 7C3) (Olfactory receptor OR19-22) (O60412)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MERGNQTEVGNFLLLGFAEDSDMQLLLHGLFLSMYLVTIIGNLLIILTISSDSHLHTPMYFFLSNLSFADICFTSTTVPKMLVNIQTQSKMITFAGCLTQIFFFIAFGCLDNLLLTMTAYDRFVAICYPLHYTVIMNPRLCGLLVLGSWCISVMGSLLETLTILRLSFCTNMEIPHFFCDPSEVLKLACSDTFINNIVMYFVTIVLGVFPLCGILFSYSQIFSSVLRVSARGQHKAFSTCGSHLSVVSLFYGTGLGVYLSSAVTPPSRTSLAASVMYTMVTPMLNPFIYSLRNKDMKGSLGRLLLRATSLKEGTIAKLS
Protein: Histone H2B 1 (Antibacterial histone-like protein 1) (HLP-1) (P81903)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- RNA polymerase-associated protein LEO1.
- Histone H2A
- Histone H2A
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
Sequence:
MPDPAKTAPKKGSKKAVTKXA
Protein: GATA-binding factor 5-A (Transcription factor xGATA-5A) (P43695)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MYPSLALTANHAQPAYSHDTPNFLHSTGSPPVYVPTSRMPAMLQSLPYLQSCDTAHQGHHLANHPGWAQTAESHAFNASSPHTPTGFSYSHSPPVGNSSARDGGYQSPLIMGGGARDQYGNTLVRTGSYPSPYSYVGADMPPSWAAGHFEGSMLHSLQGRQSLSGRRSSLEFLEEFPGEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPQKRLSSSRRAGLCCTNCHTSTTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNIGKGKTSTGSSTSANNSPSSVTNSDPTPVLKTEPNITSQYSGQAIVPVSQGHSQTDDLVNGSHELKFMPDEYTYSPTALSQQSGLSVPLRQESWCALALA
Protein: Coiled-coil domain-containing protein 40 (Protein locke) (Q56A40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BI79}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8BI79}. Note=Localizes to cytoplasm and motile cilium. {ECO:0000250|UniProtKB:Q8BI79}.
Interaction partners:
- Coiled-coil domain-containing protein 39
- Dynein regulatory complex subunit 2
- Dynein, axonemal, heavy chain 5.
- Radial spoke head component 4A.
- Dynein regulatory complex protein 1
- Dynein axonemal assembly factor 19
- Dynein axonemal assembly factor 1
- Dynein axonemal assembly factor 11
- Axonemal dynein light intermediate polypeptide 1
- Dynein, axonemal, heavy chain 11.
Sequence:
MEGRQEDQMNRQEEVEQSNNYDRSVDHARTGRSSWIDNSEINSKWIPQHSLQLEMNNIEGEGSVRENDEEEEEIVVLDPEHPLMKRFQTALKNNFTNQLERLNLDLCEKVVVEKAEAQRRHDLAEEVYMVQEMLARLQASLEVCQETNSEAAAQHRQAEDHLYVVKNQYQDTASQTNVQRLQVLELQSKVDNLALKLLYMQEAKSDLCSDIKAIINASNKAQKERTQTEEQKHQQDIYVERLTNRVEKLLEQISLYDLQLISQTEQTRAAKDSLSEAQLELDSVIVEHRQLLQQWKSSLLMMKRRDEAYTAMQEELRQANDQMLSLDTEIESYKKSITQEEEQNECLTLRLNRGQTDCTTSRKLITHSQNLQEVLQAQLSTYTRILQETENTLSTLHGNLEMHQSALKALRKQMEKVSAVRLDLESQIMNKLQEQLTHNNAAKYSRRMNDKTAVYRREKEAQLIKFENDFNTVTLEGQELATHLDSLLAFQAELEQKSTQRHLLLSSREEEIVKQITDIERKQATISIYNKKIKDIVSSTGHEDLGPLEIHAATLSKELEEVGAKIKECQQLWLWQQGELVRFTQEKQAHSSSVQILQTQLTILQQGKIRRESEMEQDQSELADLDKQIKVLMADMVKLNSLLNKNSDLNHALQQSSNLMETEFRQRLKEAEKDSAETQLKLERLNEEKERLINSLVEAERQVMLWGKRTQLMQETCSAIDSDIGQGDIRTMRAEIHRMEVRYAQLMKQQERLLRDMESVVAKSKTIAVWSEAQARTQAHKQPTHNDYHNTIQSLRRKILQTKKQTEECDGVIAQLEERLGSMTSRLQDKQMHLNNIQNTEAFLSQDLRRLQEIKERNLYRLPVLQTRAKHLHAVKEGRYTPMATGVTALELGTHKQEERLKMVSLTLQRLAQEYPQHHSTLHRMNSILAEHLHGECPNSQ
Protein: Pneumo secretory protein 2 (Secretoglobin, family 3A, member 1, isoform CRA_b) (Q71MT8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKLTAIFLVFCVALLSDSGVAFFVDSLAKPVVEPVAALAPAAEAVAGAVPSLPLSHLAILRFILASLGIPLDPLIDGSRKCVTELGPEAVGAVKSLLGALTTFG
Protein: Zgc:92052 (Q6DHU7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MESSRLQKDIDTFNQENSVYLSYEKRAEVLAGEIKDLQGQLADYNTLVDKLNTNTEMEEVVNDIIMLKAQNDREAQSIDVIFTQRRQKEDLIRAVEEQVVQQKRAAQDIIQKMSEDKQKQYREMKSSNEELLQELETHQEELDTLMSRREMLEADLLHSQAKQAAVSLHEQLLDLENRRASLQAEDRSLGSPQHERERLLTTVKENNQEIASMERQLSEVRERIIQLSEEMRQLDTDMEEHQGERTQKYKELQKKEEEIDSYLHTFEDSRSQEQQLIRDSQSSIVALLEHSSRNISRLQQLSSVTAQELQSMQEDLTFKETEMQKSQSTAKGLNSESERLQQDLLKVEQLEGKVCVELQTLRETLTLMQTEMQTYRDLQALRAAGEQRKTHLQEERVALAQRRDSFRKTLHRMLEQNETLKKQLQENEVHAELTNMERKWQHHEQNNFLMKEFVASKAVESDYRPVVKSVRKQLLDYNTLLLEALS
Protein: Erythropoietin (P29676)
Organism: Rattus norvegicus (Rat)
Function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Subcellular location: Secreted.
Interaction partners:
- Erythropoietin receptor
- Thrombopoietin
- Granulocyte colony-stimulating factor
- Leptin
- Prolactin-6A1
- Ciliary neurotrophic factor
- Prolactin
- Tyrosine-protein kinase JAK2
- Somatotropin
- Thrombopoietin receptor
Sequence:
MGVPERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILEAKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMKVEEQAVEVWQGLSLLSEAILQAQALQANSSQPPESLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDATQAAPLRTLTADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR
Protein: Manganese lipoxygenase (EC 1.13.11.12) (LOXPsa1) (Valencene dioxygenase) (ValOx) (M5EES5)
Organism: Pleurotus sapidus (Oyster mushroom) (Agaricus sapidus)
Function: Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 13S-hydroperoxy fatty acids.
Interaction partners:
Sequence:
MVHNISLSSRKALHNVHLPYMVQLPKPTGYNVALKNAAEGYDKARRMVAWLYDIADYESSIPQTFTLQQKTDKYTWELSDNFPPHLAVVPPDQSVSAPSIFSPVRLAQTLLIMSSLWYDDHTDLAPGPEQNTMQKLTQWNQERHKDQGWLIKDMFNAPNIGLRNDWYTDEVFAQQFFTGPNSTTITLASDVWLTAFTSEAKAQGKDKVIALFESAPPNSFYVQDFSDFRRRMGAKPDEELFNDSDGAMRYGCAAVALFYLTAMGKLHPLAIIPDYKGSMAASVTIFNKRTNPLDISVNQANDWPWRYAKTCVLSSDWALHEMIIHLNNTHLVEEAVIVAAQRKLSPSHIVFRLLEPHWVVTLSLNALARSVLIPEVIVPIAGFSAPHIFQFIRESFTNFDWKSLYVPADLESRGFPVDQLNSPKFHNYAYARDINDMWTTLKKFVSSVLQDAQYYPDDASVAGDTQIQAWCDEMRSGMGAGMTNFPESITTVDDLVNMVTMCIHIAAPQHTAVNYLQQYYQTFVPNKPSALFSPLPTSIAQLQKYTESDLMAALPLNAKRQWLLMAQIPYLLSMQVQEDENIVTYAANASTDKDPIIASAGRQLAADLKKLAAVFLVNSAQLDDQNTPYDVLAPEQLANAIVI
Protein: NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase) (Q13423)
Organism: Homo sapiens (Human)
Function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- NAD kinase 2, mitochondrial
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- NAD-dependent protein deacetylase sirtuin-1
- Glutamine-dependent NAD
- NAD-dependent protein deacetylase sirtuin-2
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Sequence:
MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVLASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYTAGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLLNAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (G9BWQ2)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGAGEDPMDYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLTVNWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIRE
Protein: Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) (Q9UIJ5)
Organism: Homo sapiens (Human)
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane.
Subcellular location: Postsynaptic density {ECO:0000250|UniProtKB:Q9JKR5}. Postsynaptic recycling endosome membrane {ECO:0000250|UniProtKB:P59267}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21471008}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22034844}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:22034844}; Multi-pass membrane protein {ECO:0000255}. Note=Translocates to postsynaptic density when synaptic activity decreases. {ECO:0000250|UniProtKB:Q9JKR5}.
Interaction partners:
- Cytoskeleton-associated protein 4
- Golgin subfamily A member 7
Sequence:
MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQDPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPALTMENET
Protein: Sterol O-acyltransferase 1 (EC 2.3.1.-) (Sterol-ester synthase 1) (P25628)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10672016}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sterol O-acyltransferase 2
- Phospholipid:diacylglycerol acyltransferase
- Diacylglycerol O-acyltransferase 1
- 18S rRNA
- Phosphatidic acid phosphohydrolase 1
- Ankyrin repeat-containing protein YCR051W
- Diacylglycerol pyrophosphate phosphatase 1
- Lipid phosphate phosphatase 1
Sequence:
MTETKDLLQDEEFLKIRRLNSAEANKRHSVTYDNVILPQESMEVSPRSSTTSLVEPVESTEGVESTEAERVAGKQEQEEEYPVDAHMQKYLSHLKSKSRSRFHRKDASKYVSFFGDVSFDPRPTLLDSAINVPFQTTFKGPVLEKQLKNLQLTKTKTKATVKTTVKTTEKTDKADAPPGEKLESNFSGIYVFAWMFLGWIAIRCCTDYYASYGSAWNKLEIVQYMTTDLFTIAMLDLAMFLCTFFVVFVHWLVKKRIINWKWTGFVAVSIFELAFIPVTFPIYVYYFDFNWVTRIFLFLHSVVFVMKSHSFAFYNGYLWDIKQELEYSSKQLQKYKESLSPETREILQKSCDFCLFELNYQTKDNDFPNNISCSNFFMFCLFPVLVYQINYPRTSRIRWRYVLEKVCAIIGTIFLMMVTAQFFMHPVAMRCIQFHNTPTFGGWIPATQEWFHLLFDMIPGFTVLYMLTFYMIWDALLNCVAELTRFADRYFYGDWWNCVSFEEFSRIWNVPVHKFLLRHVYHSSMGALHLSKSQATLFTFFLSAVFHEMAMFAIFRRVRGYLFMFQLSQFVWTALSNTKFLRARPQLSNVVFSFGVCSGPSIIMTLYLTL
Protein: General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) (TFIIH subunit p8) (Q6ZYL4)
Organism: Homo sapiens (Human)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
Subcellular location: Nucleus {ECO:0000269|PubMed:15220921}. Cytoplasm {ECO:0000250|UniProtKB:Q8K2X8}.
Interaction partners:
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 1
- General transcription factor IIH subunit 2
- General transcription and DNA repair factor IIH helicase subunit XPD
- Cyclin-H
- Cyclin-dependent kinase 7
- General transcription factor IIE subunit 1
- TATA-box-binding protein
Sequence:
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGELMDQNAFSLTQK
Protein: Actin-related protein 5 (Actin-like protein ARP5) (P53946)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.
Subcellular location: Nucleus.
Interaction partners:
- RuvB-like protein 2
- RuvB-like protein 1
- Chromatin-remodeling complex subunit IES6
- Actin-like protein ARP8
- Chromatin-remodeling ATPase INO80
- Actin-related protein 4
- Ino eighty subunit 1
- Ino eighty subunit 2
- Non-histone protein 10
- Ino eighty subunit 3
Sequence:
MSSRDASLTPLKAVVIDDPPLRQTPEPFDEQSAYNPQSPIAIDFGSSKLRAGFVNHATPTHIFPNALTKFRDRKLNKNFTFVGNDTLLDQAVRSQSRSPFDGPFVTNWNLTEEILDYTFHHLGVVPDNGIPNPILLTERLATVQSQRTNWYQILFETYNVPGVTFGIDSLFSFYNYNPSGNKTGLVISCGHEDTNVIPVVDGAGILTDAKRINWGGHQAVDYLNDLMALKYPYFPTKMSYLQYETMYKDYCYVSRNYDEDIEKILTLENLDTNDVVVEAPFTEVLQPQKTEEELRIQAEKRKETGKRLQEQARLKRMEKLVQKQEEFEYFSKVRDQLIDEPKKKVLSVLQNAGFDDERDFKKYLHSLEQSLKKAQMVEAEDDSHLDEMNEDKTAQKFDLLDIADEDLNEDQIKEKRKQRFLKASQDARQKAKEEKERVAKEEEEKKLKEQQWRETDLNGWIKDKRLKLNKLIKRRKEKLKLRDEMKDRKSQVSQNRMKNLASLAEDNVKQGAKRNRHQATIDNDPNDTFGANDEDWLIYTDITQNPEAFEEALEYEYKDIVELERLLLEHDPNFTEEDTLEAQYDWRNSILHLFLRGPRPHDSENIHEQHQMHLNVERIRVPEVIFQPTMGGQDQAGICELSETILLKKFGSQPGKLSQTSIDMVNNVLITGGNAKVPGLKERIVKEFTGFLPTGTNITVNMSSDPSLDAWKGMAALARNEEQYRKTVISKKEYEEYGPEYIKEHKLGNTKYFED
Protein: Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) (Q9CQU5)
Organism: Mus musculus (Mouse)
Function: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O95229}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:26486467}. Note=Localizes to kinetochores from late prophase to anaphase (By similarity). Localizes to kinetochores both during mitosis and meiosis (PubMed:26486467). {ECO:0000250|UniProtKB:O95229, ECO:0000269|PubMed:26486467}.
Interaction partners:
- Kinetochore-associated protein DSN1 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Kinetochore protein NDC80 homolog
- Kinetochore protein Nuf2
- Centromere/kinetochore protein zw10 homolog
- Kinetochore protein Spc24
- Kinetochore-associated protein NSL1 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Kinetochore protein Spc25
- Cell division cycle protein 20 homolog
Sequence:
MADAEKNAVAEKNNAVATKEVLAEAAAILEPVGLQEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDTEQSPDALASEDASRQKATETKEQWKDMKATYMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISEGKAEDKDVKGRALTAKSKSP
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q385R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein {ECO:0000256|RuleBase:RU365079}.
Interaction partners:
Sequence:
MSDLRRVESLNADTFRRLNATSVVKSFWHTQLRAATAASRGAKDDSLATANEETPVATRKLRSAASSAEKSAGGLTDSTVYSSSSSSSNSRLSVSATLPGFPSPTETRRRLRAAALSAERHRAEESDEEKPDPVARTLFQNFLLQEYDALDSRPVLTVVLDLDETLVSNRDSGATGAILRPYCLHMLNALRHMQGLEVVLWTASTKETAAPVIRQLSQSGPVFDDVICRNSSWFTEPLHTKDLRLLGRDMSRVIIFDNSTACCKLNPRNAVIVDDFRGVRNTSDAALVNVYYIIERSFNGCCAGVSVLETLVKLAVEKQLCMPEVLHLPESWRHIPLREIAPLKVPPHGIFFRAHSTPLNDSIMQHWTV