wanglab/gogpt-training-data huggingface dataset:
Protein: Forkhead-associated domain protein (Q84K72)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Peroxisomal membrane protein 11B
- FHA domain-containing protein DDL
Sequence:
MVTTTIGGVPVVIAQSRRIPTSLRCFSATANSDLLRSQLDRLHAEAESTRAKANSNRLRLLRLSEAAENLREQAAVNVRTGKENDARDLLLQKKKVMQALDKAKARIELLDTLSSKLNEAISVKETQLIGNISLDLEEDGENTSGGIHIVSPKPESTEDGVENDHTHLDSEGIQLIERNVEDYQELLDTNNNVLEDVSIGSILKEVSSYESFLENLDQKLSRIEAELVTVVNVASLVLNHEDKPKNLKVQQTAEILEEIRRVRERIANIICKEANIS
Protein: Leucine-rich repeat-containing protein 51 (Q580G7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- U2 small nuclear ribonucleoprotein B, putative
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Sm protein B
- Sm protein G
- PHD finger-like domain-containing protein 5A
- Sm protein F
- Small nuclear ribonucleoprotein SmD1
- Splicing factor 3A, putative
- Probable eukaryotic initiation factor 4A
Sequence:
MEFEQLEIGKKSITNAIARQEVTDYYDLLHPNVLLVSHFRYPPLSPVIADTIPALDRVLRKENKNLSGVTKGHNPWKVPEFLQTGAVTKSAPVAAPAVTATSPTTTSTTVTTRANSPHLAGTPTRASIVPKAPGGRPVARGFAARKRRGTSTNGRSTATGDRSTSAATRERREDPNKKKQRQSTITGPYEADIVEGPLLVTARFYAILQWMNQGAHIADTVFDMEARKVVLQESDVVLQLPAPKTEAEWYAQLGRQHTDRNQRLSRLTVTYGRDLLLFRDECYFEDGFIVTIHRFMLTQQEMLDLSSLVEYHQQAEINRRIEAMKVERDNFYAAEQRRVNAFRRSVEPLLDFTFCDVSDPILLLSVEPVAGKRHICKDVRPKNVTALPPMGYGAQQNDAQRGKDQRIVVKARNKAGDEEVYEFVDNSKPRYDFLYDPKTNAESTLQNLADKMKSMFCTSSVRISSCGMRSTDQLVPVLRRLVANAIMTIRALDLSDNEISTLPDLSLLPLQRLLLHKNKISDWMEVENRVCVLPLLEVVTLHGNPISESNEQYRQELLARLLRHPRRAARVRQVDFVTLTAQDLNIAGTFEMFTTGNTSVLEKARKFNVSDVRKKI
Protein: Carboxypeptidase B (EC 3.4.17.2) (F1QJN9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}. Zymogen granule lumen {ECO:0000256|ARBA:ARBA00037795}.
Interaction partners:
- chymotrypsin
- Alpha-2-antiplasmin
- Angiotensinogen
- Peptidase S1 domain-containing protein.
- Chymotrypsinogen B1
- Alpha-2-antiplasmin, member 2a)
- Cysteine and glycine-rich protein 1b.
Sequence:
MKLFLLLGLVAVALCEPITFVGDKVLQLKPINDEHVTIIRELGEKIKLDFWKPRSADLVSIDMTVDIHVPAAQLAMVSTILQQSDMEVKVMIDNLQEAVKGQMDNRSPTKGHDYTKYNSWATINDWAISISSANPDLISRQSIGNTYEGRTMHLLKIGKNTGSNKPAVFMDCGFHAREWITHAFCQWFVNEAVSTYGSDPDMTNLLDRMDFFVLPVFNIDGYEYTWNRDRMWRKTRSKNSGSSCIGTDPNRNFNAGWCTVGASSNPCSDTYCGSSPESEIESKNLANFIRTNKSVIKAYLTVHSYSQLLLFPYSYKYDLAAHHSELMSVSQGAIAALRSLYGTKYTSGPGAATIYPAAGGSDDWAYDLGVKYSYTFELRDEGRYGFLLPESQIKPTCEETMLAVKYIANHVLNNLY
Protein: Nuclear respiratory factor 1 (Nrf-1) (Not really finished protein) (Q90X44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable transcription factor that is required for normal development of the outer retina.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor A
- Nfe2-like bZIP transcription factor 3
- Nuclear factor, erythroid 2-like 2b.
- Endoplasmic reticulum membrane sensor NFE2L1
- Endoplasmic reticulum membrane sensor NFE2L1
- Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
Sequence:
MEDHTVHQTEHMTTIEAHAVSQQVGQVHVATYTEHGMLSADEDSPSSPDDDAYDDSDILNSTGTDEVTAHLAAAGPVGMAAAAAVATGKKRKRPHIFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFRVFGAAPLENVVRKYKSMILEDLENALAEHAPPGGGELSSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQVTTQVATTATHSIAHLVPSQTVVQTISNPDGTVSLIQVGTGATVATLADASELPGTVTVAQVNYSTVTDGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQTGATVTMALNRYSLEGALKFGEAAAHAVATLAEATLQGGGQIVLAGETAAAVGALTGVPDGSGLVQIPVSMYQTVVTSLAQGNRPVQVAMAPVTTRIDNTMTLDGQAVEVVTLEQ
Protein: Olfactory receptor 52L1 (Olfactory receptor OR11-50) (Q8NGH7)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MTLVSFFSFLSKPLIMLLSNSSWRLSQPSFLLVGIPGLEESQHWIALPLGILYLLALVGNVTILFIIWMDPSLHQSMYLFLSMLAAIDLVLASSTAPKALAVLLVHAHEIGYIVCLIQMFFIHAFSSMESGVLVAMALDRYVAICHPLHHSTILHPGVIGRIGMVVLVRGLLLLIPFPILLGTLIFCQATIIGHAYCEHMAVVKLACSETTVNRAYGLTMALLVIGLDVLAIGVSYAHILQAVLKVPGSEARLKAFSTCGSHICVILVFYVPGIFSFLTHRFGHHVPHHVHVLLATRYLLMPPALNPLVYGVKTQQIRQRVLRVFTQKD
Protein: Vacuole membrane protein 1 (Q6NYY9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by atg2 (atg2a or atg2b) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Modulates ER contacts with lipid droplets, mitochondria and endosomes.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q96GC9}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96GC9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beclin-1
- Autophagy-related protein 13
- EI24 autophagy-associated transmembrane protein.
- Autophagy protein 5
- Transmembrane protein 41B
- Ubiquitin-like protein ATG12
- Apolipoprotein D
- Ubiquitin-like-conjugating enzyme ATG3
- Ectopic P granules protein 5 homolog
- Ubiquitin-like modifier-activating enzyme ATG7
Sequence:
MAANGAECEQPQKRLGPKDKQNGSSTDSSLRERKQLDREERLSLVLWKRPFITLQYFFLETAITLKEWTWKLWQRRGVVFLTVVLFSLFSLAYSIEGAHQEYVQHLEKKFLWCAYWVGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECGSVNFPEPPYPAQIVCPEDEALQESISLWTIMSKVRLEACMWGAGTAIGELPPYFMARAARMSGADPDDEDYEEFEEMLEHSQSAQDFASRAKLAVQNMVQKVGFFGILACASIPNPLFDLAGITCGHFLIPFWTFFGATLIGKAIIKMHIQKLFVIITFSKHIVEQMVSLIGVIPGVGASLQKPFREYLEAQRTKLHNPAGDGAAAGESWLSWVFEKVVLVMVCYFILSIINSMAQSYAKRLQQKKYSEEKTK
Protein: Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome subunit beta-3) (beta-3) (Proteasome theta chain) (Q9R1P1)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P49720}. Nucleus {ECO:0000250|UniProtKB:P49720}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P49720}.
Interaction partners:
- Proteasome subunit beta type-9
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-2
- 26S proteasome non-ATPase regulatory subunit 8
- Proteasome subunit beta type-10
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-5
Sequence:
MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD
Protein: Maleamate amidohydrolase (EC 3.5.1.107) (Nicotinate degradation protein F) (Q88FY5)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Function: Maleamate amidase that transforms maleamate into maleate and ammonia in the aerobic nicotinate degradation pathway.
Interaction partners:
- N-formylmaleamate deformylase
- Maleate isomerase
- 2,5-dihydroxypyridine 5,6-dioxygenase
- 6-hydroxynicotinate 3-monooxygenase
- Putative metabolite transport protein NicT
- Electron transfer flavoprotein, alpha subunit
- Hydrolase, isochorismatase family
- Oxidase
- NADH dehydrogenase
Sequence:
MSDAQSARDNYQGVWGQRIGFGRKPALLMIDFMQGYTTPGAPLYAPGVVAAVEQAAGLLALARDCGTLVVHTNIRYQPPHFADGGVWVRKAPVMKDMVEGNPLAAFCEAVAPQAGEVVLSKQYASAFFATSLAPLLHAQGVDTVVLAGCSTSGCIRASAVDAMQHGFRTIVVRECVGDRHSDPHEANLFDIDSKYGDVVTRQDAMQQLRHLAG
Protein: DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) (Q9UBT6)
Organism: Homo sapiens (Human)
Function: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}. Note=Detected throughout the nucleus and at replication foci (PubMed:12414988). Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK (PubMed:28297716). {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}.
Interaction partners:
- Proliferating cell nuclear antigen
- DNA repair protein REV1
- Cellular tumor antigen p53
- DNA polymerase zeta catalytic subunit
- Mitotic spindle assembly checkpoint protein MAD2B
- DNA repair protein RAD51 homolog 1
- DNA polymerase delta catalytic subunit
- DNA polymerase eta
- DNA polymerase iota
- DNA polymerase delta subunit 2
Sequence:
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTRTKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
Protein: Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein) (Q99732)
Organism: Homo sapiens (Human)
Function: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15793005}. Nucleus {ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:16954198}. Lysosome membrane {ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:27582497}; Peripheral membrane protein {ECO:0000269|PubMed:11274176}; Cytoplasmic side {ECO:0000269|PubMed:11274176}. Early endosome membrane {ECO:0000269|PubMed:21896645, ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:27582497}. Late endosome membrane {ECO:0000269|PubMed:27582497}. Endosome membrane {ECO:0000269|PubMed:27927196}; Peripheral membrane protein {ECO:0000269|PubMed:27927196}; Cytoplasmic side {ECO:0000269|PubMed:27927196}. Cell membrane {ECO:0000269|PubMed:16118794, ECO:0000269|PubMed:27582497}; Peripheral membrane protein {ECO:0000269|PubMed:27582497}; Cytoplasmic side {ECO:0000269|PubMed:27582497}. Golgi apparatus membrane {ECO:0000269|PubMed:16118794}. Note=Associated with membranes of lysosomes, early and late endosomes (PubMed:11274176, PubMed:27582497, PubMed:27927196). Can translocate from the cytoplasm into the nucleus (PubMed:15793005). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity). {ECO:0000250|UniProtKB:Q9JLJ0, ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:27582497, ECO:0000269|PubMed:27927196}.
Interaction partners:
- E3 ubiquitin-protein ligase NEDD4
- mRNA cap guanine-N
- Tumor susceptibility gene 101 protein
- Epithelial membrane protein 2
- E3 ubiquitin-protein ligase Itchy homolog
- SH3 domain and tetratricopeptide repeat-containing protein 2
- BAG family molecular chaperone regulator 3
Sequence:
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL
Protein: Putative cyclin-dependent kinase inhibitor SPL2 (Suppressor of PLC1 deletion protein 2) (P38839)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative cyclin-dependent kinase (CDK) inhibitor necessary and sufficient for PHO pathway-dependent down-regulation of low-affinity phosphate transport.
Subcellular location: Cytoplasmic granule {ECO:0000269|PubMed:14562095}. Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Inorganic phosphate transporter PHO84
- Vacuolar transporter chaperone 3 complex subunit 3
- Acid phosphatase PHO11
- Phosphate metabolism protein 6
- Phosphate permease PHO89
- Vacuolar transporter chaperone complex subunit 1
- Inorganic phosphate transporter PHO87
- Low-affinity phosphate transporter PHO90
- Vacuolar transporter chaperone complex subunit 4
- Phosphate system positive regulatory protein PHO81
Sequence:
MGTYTPLIYNIYNVHIWVFTESQGQIGQMSPRGKMETAVSQGQHKQLKDGHQHKGRKLSEEIASLLRLKECRRLNPASYYTPRRTSQSQSLSGSTFKEYNEYINEKDSSRAQRQNAAAVLSKLAHDFWENDCVIDEDIFEDSSDEEQS
Protein: GPCR-type G protein 1 (Q9XIP7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Abscisic acid receptor. The GDP-bound form exhibits greater abscisic acid binding than the GTP-bound form. Required for seedling growth and fertility.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19135895}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:23001037}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23001037}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- LanC-like protein GCR2
- Guanine nucleotide-binding protein alpha-1 subunit
- Magnesium-chelatase subunit ChlH, chloroplastic
- G-protein coupled receptor 1
- Abscisic acid receptor PYR1
- Abscisic acid receptor PYL2
Sequence:
MSYGWAIYEGTVVIASLSLLGWAGLWFLNRRLYKEYEEKRALVQIIFSVVFAFSCNLLQLVLFEIIPVLSREARMINWKVDLFCLILLLVFMLPYYHCYLMLRNSGVRRERASVGAFLFLSAFLYAFWRMGVHFPMPSADKGFFTMPQLVSRIGVIGVTLMAVLSGFGAVNLPYSYISLFIREIEEADIISLERQLIQSTETCIAKKKKIILCQLEVERNQGSEENQKRSSFFRRIVGTVVRSVQDDQKEQDIKILEAEVEALEELSKQLFLEVYELRQAKDAAAYSRTWKGHVQNLLGYACSIYCVYKMLKSLQSVVFKEAGTKDPVTTMISIFLRLFDIGVDAALLSQYISLLFIGMLIVISVRGFLTNLMKFFFAVSRVGSGSSSNVVLFLSEIMGMYFLSSILLIRKSLRNEYRGIITDVLGGDIQFDFYHRWFDAIFVASAFLSLVLLSAHYTSRQSDKHAIE
Protein: Origin of replication complex subunit 1B (AtORC1b) (Origin recognition complex 1b protein) (Protein UNFERTILIZED EMBRYO SAC 13) (Q9SU24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required for ovules fertilization. Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that regulates positively the transcription of a subset of genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P54789, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Origin of replication complex subunit 6
- Origin of replication complex subunit 3
- Origin of replication complex subunit 5
- DNA replication licensing factor MCM5
- Origin of replication complex subunit 2
- DNA replication licensing factor MCM3
- CDT1-like protein b
- Origin of replication complex subunit 4
- CDT1-like protein a, chloroplastic
- DNA replication licensing factor MCM7
Sequence:
MASTPRAKTFKSPTKTPSNIYRKSYLSPSSTSHTPQTPETHTPLRRSARHVSRKIDLGNDPIDAPGNDPIEGMNLIRKRERAPRKPTTDVVPSKSKKTETPKKKKKIDSFTPVSPIRSETIKKTKKKKRVYYNKVEFDETEFEIGDDVYVKRREDSNSDEEEDPEIEDCQICFKSDTNIMIECDDCLGGFHLKCLKPPLKEVPEGDWICQFCEVKKSGQSQTLDLPKPPEGKKLARTMREKLLSGDLWAARIDKLWKEVDDGVYWIRARWYMIPEETVSGRQPHNLKRELYLTNDFADIEMECILRHCSVKCPKEFSKASNDGDDVFLCEYEYDVHWRSFKRLAELADGDSDSDQEWNGRKEEEVDDSDEEMELDDEVLKSKRGGLTSARGGANSRKGRFFGVEKVGMKLIPEHVRCHKQSELEKAKATLLLATRPKSLPCRSKEMEEITSFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEEGSVSPYCFVEINGLKLASPENIYSVIYEALSGHRVGWKKALQCLNERFAEGKRIGKEDEKPCILLIDELDLLVTRNQSVLYNILDWPTKPNSKLVVLGIANTMDLPEKLLPRISSRMGIQRLCFGPYNHTQLQEIISTRLNGIDAFEKTAIEFASRKVAAISGDARRALEICRRAAEVADHRLNTNKSAKNQLVIMADVEAAIQEMFQAPHIQVMKSVSKLSKIFLTAMVHELYKTGMAETTFDRVATTVSSICLTNGEAFPGWDILLKIGCDLGECRIILCEPGEKHRLQKLQLNFPSDDVAFALKDNKDLPWLANYL
Protein: BRCA1 associated RING domain 1 (F6MDI1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
Protein: Matrin-type domain-containing protein (Q38C31)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDSFALDDARRIKRRRRLSRMSIEGRRRQLQYRRRHNERDGRLLYCDYCDLFVCSSLRSWGEHVISERHMENMECYYAMVEAYEPSWLGSICDDVSRAHVENHVRRHQSVSGKGSSVPIPAVVAGRVDDQEIIVGGLPKPSRTAAETYNNSCNIAGTPSVRVAGVLVASAAPPVVKVGNKPVTPTPLSVTKRE
Protein: MADS-box protein AGL24 (Protein AGAMOUS-LIKE 24) (O82794)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that mediates floral transition in response to vernalization. Promotes inflorescence fate in apical meristems. Acts in a dosage-dependent manner. Probably involved in the transduction of RLK-mediated signaling (e.g. IMK3 pathway). Together with AP1 and SVP, controls the identity of the floral meristem and regulates expression of class B, C and E genes. When associated with SOC1, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development. Confers inflorescence characteristics to floral primordia and early flowering.
Subcellular location: Nucleus. Cytoplasm. Note=Translocation from the cytoplasm to the nucleus in the presence of IMK3.
Interaction partners:
- Protein LEAFY
- Protein TERMINAL FLOWER 1
- MADS-box protein SOC1
- Agamous-like MADS-box protein AGL8
- Protein TWIN SISTER of FT
- Agamous-like MADS-box protein AGL80
- MADS-box protein
- Probable leucine-rich repeat receptor-like protein kinase IMK3
- Inactive protein FRIGIDA
- Polycomb group protein VERNALIZATION 2
Sequence:
MAREKIRIKKIDNITARQVTFSKRRRGIFKKADELSVLCDADVALIIFSATGKLFEFSSSRMRDILGRYSLHASNINKLMDPPSTHLRLENCNLSRLSKEVEDKTKQLRKLRGEDLDGLNLEELQRLEKLLESGLSRVSEKKGECVMSQIFSLEKRGSELVDENKRLRDKLETLERAKLTTLKEALETESVTTNVSSYDSGTPLEDDSDTSLKLGLPSWE
Protein: Probable acyl-CoA dehydrogenase FadE1 (P96808)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible acyl-CoA dehydrogenase FadE36
- propanoyl-CoA C-acyltransferase
- Probable fatty oxidation protein FadB
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase beta1 subunit
- Acyl-CoA dehydrogenase FadE7
- Possible enoyl-CoA hydratase EchA21
- Enoyl-CoA hydratase EchA19
- Probable enoyl-CoA hydratase EchA5
- Probable enoyl-CoA hydratase EchA8
- Probable enoyl-CoA hydratase EchA14
Sequence:
MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
Protein: Regulatory protein SIR1 (Heterochromatin protein SIR1) (Silent information regulator 1) (P21691)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the establishment, but not the maintenance, of heterochromatic silencing at the cryptic mating-type loci HMR and HML. Is recruited by interacting with the ORC1 subunit of the origin recognition complex (ORC), which binds to HML-I or HMR-E silencers, DNA elements that direct the formation of silent chromatin at the mating-type loci. Establishes transcriptional silencing by recruiting the three other SIR proteins, SIR2, SIR3, and SIR4, that function directly in silenced chromatin and establish repression. Also found in centromeric chromatin. Binds to and helps retain CAC1, a subunit of chromatin assembly factor I (CAF-I) at centromeric loci independent on the other SIR proteins.
Subcellular location: Nucleus. Chromosome, centromere. Note=Associated primarily with the HMR-E silencer at the HMR locus.
Interaction partners:
- Origin recognition complex subunit 1
- Regulatory protein SIR4
- Regulatory protein SIR3
- NAD-dependent histone deacetylase SIR2
- Histone acetyltransferase SAS2
- Tyrosine-protein phosphatase CDC14
- Nucleolar protein NET1
- DNA-binding protein RAP1
- Histone H4
- N-terminal acetyltransferase A complex subunit NAT1
Sequence:
MLQINSRLAVIDGWLVDTVKRKPINFRSPEVRLLLPNDDDYKKLSQQNLVDWTRLKKDSNSVLVGVKSMELFKHIKLVLREFFLLEDGRIILKRIRSKLRYKVVKKLTCKCCRLYLPKWGTVYIHPMLKDKEKPLAGVCEFSLDVNPDREYPLIEINVSHQYIIIEGFLLYLNERRLYRWNDNNLRSQVGLTKWAHLRKTYNPVSLDILYSLNSNFYFVKDDLLFQLLGKRVFVKFCKVMENGKCGKAPLWYRVKRTTTAKATHIAYAISNSTAPDSFKSKNNDYRFIVREKPIVENTISNLDYSDIKKQQFTEAEVVKRKISADISQIENVHTQFNSQKEKNNIRVNKVSSEVLDQISKFPVSRVTLLLMSAGQDKNYIELVEELARRLEKICIEKTTQSLEEIRDTFQANPEMQASFDKEYYQSIEEYKITLELIKEDLLITLIKQMENMWAAEKKFSTEEEYVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKDHQRAMIDQMNLVKWNDFKKYQDPIPLKAKTLFKFCKQIKKKFLRGADFKLHTLPTEANLKYEPERMTVLCSCVPILLDDQTVQYLYDDSIIPEFEATSSYATKQSKCGRKMSLQMEPDLLFQEAIRRMRHLTAYDVLRRNYIAAFEELYMGNCND