wanglab/gogpt-training-data huggingface dataset:
Protein: Taxoid 2-alpha-hydroxylase (EC 1.14.14.-) (Q6JD68)
Organism: Taxus canadensis (Canadian yew)
Function: Catalyzes the conversion of taxusin to 2-alpha-hydroxytaxusin in taxol biosynthesis. Catalyzes the conversion of 7-beta-hydroxytaxusin to 2-alpha-7-beta-hydroxytaxusin in taxol biosynthesis.
Subcellular location: Microsome membrane {ECO:0000269|PubMed:15178487}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDAMDLTVAKFKEFTQLQSSAILLTVVSGIIVIVILLLRSKRRSSLKLPPGKLGLPLIGESLSFLWALRSNTLEQFVDKRVKKYGNVFKTSLLGQPTVVLCGAAGNRLILSNQEKLLSRTVSDRVAKLTGDTSISVIAGDSHRIIRAAVAGFLGPAGLKIHIGEMSAHIRNHINQVWKGKDEVNVLSLARELVFAISASLFLNINDREEQHQLHKTLETILPGYFSVPINFPGFAFRKALEGNSKRRKHFSVLQEKRRRDLSVGLASRTQDLLSVLLAYEDDKGNPLTDEEVLDNISALIDGSYESTSSQMAMLLKLLSDHPECYEKVVQEQLEIASHKKEGEEITWKDVKAMRYTWQVMQETLRMFAPVFGPRGKAITDIHYDGYTIPKGWQLSWATYSTHQNDTYFNEPDKFMPSRFDEEGGRLAPYTFVPFGGGRRKCPGWEFAKTEILLFVHHFVKTFSAYTPIDPHESIWGRPLPPVPANGFPIKLISRS
Protein: Uncharacterized protein (Q38B47)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MESPPSNDEKHELAVALRLKEEDDALLCAFGPDYFNGARVGAGCGGVFTAFLAWWSFVDLKEDHKLCDSALPTHMRDRSWTIRRGFHSRPFFTVGCVALGITTLMKATKFCLANYRYQEFAADDIGFELLKSMYVSSPEGHRQFEAFVKKTIGNEKVLELPSPSTNFATGGKIRNNQNLTETLVSSTSSFCDRKPPSFWDGVAVGIMGSVMDCYLPCKPLYSYYGMRCGMRL
Protein: Shal K[+] channel interacting protein, isoform E (Shal K[+] channel interacting protein, isoform F) (Q0KI30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAVSNIVCEWLRALGLAQYAESFLDNGYDDLEICKQVGDPDLDAIGVENPAHRHKLLKSIRSLREKGAASVYFMLNDPNSLSGSMEILCETPPNNELELVLREQLETDGVRLTAHPYSTPDGQRGHLEGLASVYCELLMAPFGDILATIERARQAAWAERSPLHSAAQVVGGSGGAGGSTGSGSGGAASGGSGGSSGVLHHRQQHGHRGHSMHGAGLPNSHSQPIYVPGKYSPSSCLSDKEEDEIYGFGYGVFAPRVARGGLTQQQQLLQQQTLQTQQSIQQQQQQMQQQQQQLPIVPGQQQQGPHQHQTLPPNVAHLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSFEETIHRLKVQEAMRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNGGGGGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRVRFSNNRESTGVISLRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTSMASCICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESNSLDDVVTKCSSEIMKRVESARRCKDNPFKTTLPGGGRLGKKSFLGGNGLMADDTLTRGGLSEKSSDSGVSSSSLSSGPLKSST
Protein: Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) (Q86VP3)
Organism: Homo sapiens (Human)
Function: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:15692567}. Mitochondrion {ECO:0000269|PubMed:15692567}.
Interaction partners:
- B-cell receptor-associated protein 31
- Calnexin
- Mitofusin-2
- WD repeat-containing protein 37
- Regulator of microtubule dynamics protein 3
- Polycystin-2
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Stress-70 protein, mitochondrial
- Vesicle-associated membrane protein-associated protein B/C
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Sequence:
MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLCSSIKEAPVKAAEIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSDEVLDSEQDPAEHIPEAEEDLDLLYDTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHKEPPSPADVPEKTRSLGGRQPSDSVSDTVALGVPGPREHPGQPEDSPEAEASTLDVFTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQAARPQNERANSLDNERCPDARSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGTLSSTPPSASPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF
Protein: Bazooka, isoform D (X2JCB3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFDVPPKCPALANKLGGLFGWRHTYKVAAKQEGIPHGQLHKSYSLTLPKRPPSPSTYSCVKPDSWVTVTHLQTQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPRGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLHQQHQQHQISRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQPQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMNGYSPASLNSSARSRGPFVTQVTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQKMSGPSQYGSAAGSQPHASKV
Protein: Kinesin-like protein KIN-14Q (Kinesin O12) (OsKCH1) (Q0IMS9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Minus end-directed motor protein that transports actin filaments along microtubules. Plays a central role in the polar orientation of actin filaments along microtubules, and thus a contribution to the organization of the cytoskeletal architecture. Links the actin microfilaments with the cortical microtubules in both cycling and non-cycling cells. Required for efficient cell elongation by its participation in the premitotic nuclear positioning.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19561334, ECO:0000269|PubMed:21047815}. Note=Colocalizes with cortical microtubules and longitudinally oriented actin microfilaments. {ECO:0000269|PubMed:19561334}.
Interaction partners:
- Kinesin-like protein KIN-10A
- Kinesin-like protein KIN-5A
- Kinesin-like protein KIN-5B
- Kinesin-like protein KIN-5C
- Os01g0189100 protein
- Os02g0492900 protein
- Os12g0600100 protein
- Os09g0124800 protein
- Os03g0679800 protein
- Os03g0680600 protein
Sequence:
MMAAAVEEEEMVERMHGWARDMDVASRRAEEEAMRRYDAASWLRSTVGVVCARDLPDEPSEEEFRLGLRNGIVLCNALNKIQPGAIPKVVQAQSDAAGPTDGSALCAYQYFENLRNFLVVVEDLRLPTFEVSDLEKGGKGVRVVDCVLALKSFSESNKTGRQASCKYGGLSKPLTARKYFILKNTDAFMNKIMKGHSAEAIQSEFSEGQSIVTDFSIESNEMTTSDSLSILLRKVLLDKKPEEVPLIVESILSKVIQEYEHRIAIQNKMDEEEQNLLNITEQVNHVVVNGDGEVKQFQLEAQTNFDVQQKQIQELKGALSFVKSGMEQLRLQYSEEFAKLGKHFYTLSNAASSYHKVLEENRKLYNQIQDLKGNIRVYCRVRPFLPGHRSLSSSVADTEERTITIITPTKYGKDGCKSFSFNRVFGPASTQEEVFSDMQPLIRSVLDGFNVCIFAYGQTGSGKTFTMSGPKVLTEESLGVNYRALNDLFNIKAQRKGTIDYEISVQMIEIYNEQVRDLLQDGGNRRLEIRNTPQKGLAVPDASIVPVTSTADVVELMNQGQKNRAVGSTAINDRSSRSHSCLSVHVQGKYLTSGAMLRGCMHLVDLAGSERVDKSEVVGDRLKEAQYINKSLSALGDVIASLAQKNSHVPYRNSKLTQLLQDSLGGQAKTLMFVHVSPELDAVGETISTLKFAERVASVELGAAKANKEGSEVRELKEQIATLKAALAKKEGEPENIQSTQSSPDMYRIKRGNAIPAFPKNRQPMEEVGNLEVRNNATPMQKKASFQFSGVLSENNSSDLAENCNGIQKTDRMAVGNNQFENGNSILELEPGATQLPTFFYQRYDPDKQRRRAEPVETDDSDSFDAATSSPSDQEMLLSTSGLKADGIASRGAFIIKKPQTKNTKITATKIPNLAMKSPMSEKRLQTPIRNSKQLPFSTTGGRRTRNGKINTPK
Protein: Prespore vesicle protein (PSV) (P08798)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Spore coat protein SP85
- Prespore-specific protein E
- Peptidase C1A papain C-terminal domain-containing protein
Sequence:
MRLYLLSLILVFYASVSSASLDSVNFGRGGGWGSGNQGVLCGTHYCPPGSTCESKHGHYICRPGGLITAPSGGDSGGIWTGGDKHKKDCGGTGCCKEGQYCTKLDGKEQCVYYPDDKGPQCGGSFCREGEICVLEHGVLGCLENPVEDSKANCGLFHCNYNEYCIMVNGYLQCLFSNGTAPFACGLQTCVPPQLCVKVENCQQCVSPPRPDNNCGDKYCDDEHQCVRKGLGYECIPKRLTCETKKCEASQVCIMVNGDAQCIVPPAAAAAEIRINNFRFNRNSVQRNAKPAQQQRSAQHAKPAQHGKPAQHATQQQHAKPAQNAKPVQHNAQQQHAKPAQHAAQQQHAKPAQHVAQQQQQQHAKPAAHTAAKPVQHNAQQQHAKPAAHTAAKPVQHNAAQQHAKPAAHGAKPAVNAARPVQHNAAQQHAKPAAHTAAKPVQHNAAQQHAKPAAKPAKLTNAQKLQQEHQRQEALAKQQARIRQQNLVKQAAQKKQTSQRAASKNQARPATQKRN
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (K7EP28)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
VERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLVRAPLGVGDGPLPQLGFDPTRPSFPSELMG
Protein: Heme transporter hrg1-A (zHRG-1) (Heme-responsive gene 1 protein homolog A) (HRG-1A) (Solute carrier family 48 member 1-B) (Q7T3B2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q6P1K1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P1K1}. Lysosome membrane {ECO:0000250|UniProtKB:Q6P1K1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P1K1}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9D8M3}; Multi-pass membrane protein {ECO:0000255}. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. {ECO:0000250|UniProtKB:Q9D8M3}.
Interaction partners:
- Si:ch211-201o1.1.
- Probable RNA polymerase II nuclear localization protein SLC7A6OS
Sequence:
MAFNKTYIRVGYSCMGMLVGFSAFLVWNIAYKQPWTAAMGGLSGVLALWALVTHIMYIQDYWRTWLKGLKFFMAMGVIFSVLSIVAFISFLCVAISRQQSLTDPTSLYLSCVWSFMSLKWSFLLTLYSHRYRKEFADISILNDF
Protein: Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (A4LAA3)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEESFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPPMRSKNPGPSQGKSM
Protein: Glypican-3 [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] (Q6V9Y8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By similarity). Modulates the effects of growth factors on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P13265}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}.
Interaction partners:
- Syndecan
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Exostosin glycosyltransferase 2
Sequence:
MMPGLKLYGALILCVLVLPFSRPSSQVLDCREVRSSFQFLYPGMKWTPETPVSGSDLQVCQPKGLTCCSRKMEERYLLIAKQNMESSLQATSAQLKGLIIQNAALFQEAFDMVLRLGRNSTLMVLREEFPGLGAGASGAVTQLFLDMSLYILGSDANVNDMVSTFFSRLFPLTYRRLLGNGAVAGISEECLRGAWKGSSAYGSFPKMMMTRLSRSLLATRVFLQALNLGIEVVNTTQHLRAGRDCGRSLLKLWYCPHCQSLLEARPCRPLCVSTMGACLGGTTEVQPHWRAYVDELGSLAAAMKGEQDIEAVVLRLHVIIRQALKQAVASKSKVSAQVSGMCVHAPPRVSRAVPVSAEHTSASTVNHNRPPMNFDPDETLFGRRREFISGLRGFSQFYSGLGEALCSKEPTSLNSSLCWNGQEMTDKFPGPGLKRVHPHGSESKQKTPEPVISQIIDKLKHINQLLRMVTLPEKRWRARQGGGGARRNPSGPGQTDEDEEGLESGDCDDEDECTGVSGLGPPPRRKRLRIFADLADNLAIDDLTLHELLLTPRLATDAHGGSSIPGAAHVPTAAFIFTITIIIFITLGLQ
Protein: Granulocyte colony-stimulating factor (P97712)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Granulocyte colony-stimulating factor receptor
- Eotaxin
- Granulocyte-macrophage colony-stimulating factor
- Erythropoietin
- Interferon gamma
- Interleukin-1 beta
- Interleukin-1 alpha
- Thrombopoietin
- Leptin
- 26S proteasome non-ATPase regulatory subunit 6
Sequence:
MKLMALQLLLWHSALWSGQEAIPLLTVSSLPPSLPLPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQALQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAPTVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHLPRPAQKHFPESLFISI
Protein: Putative peroxisomal biogenesis factor 19 (Peroxin-19) (P34453)
Organism: Caenorhabditis elegans
Subcellular location: Peroxisome {ECO:0000305}.
Interaction partners:
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX14
- Peroxisomal biogenesis factor 3
- Peroxisome assembly protein 12
- Peroxisomal biogenesis factor 11
- T-complex protein 1 subunit delta
- Peroxisomal ATPase PEX1
- Peroxisomal ATPase PEX1
- TPR_REGION domain-containing protein
- Peroxisomal Membrane Protein related
Sequence:
MTDETTQNIKDKTEEELAALLDQTLGEFTATPAPKPRTTDDELDELMASADQEAAQKAAKDFQKMLEQMVTLQEEAMKKAGADPSEGEGEQPLDPNDPEALAMMDALKQLMECSSNVANASNPEEFMAGLDMLRSPNSPMEPFMSMIMQTLASKEVMYPPLKEIFDNYPKYLEDNGAGLDAETKERYEKQFEVLGKICTEFEKQPELAEVQPVDAATQPAPEADPASIEHFEKLGKLLVELQQYGYPPKELVGALPDGWQIDESGLPKVADAAAATEACSIM
Protein: Eukaryotic translation initiation factor 3 subunit H-A (eIF3h-A) (Eukaryotic translation initiation factor 3 subunit 3-A) (eIF-3-gamma-A) (eIF3 p40 subunit A) (Q6AXJ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit D
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- Eukaryotic translation initiation factor 3, subunit F
- Eukaryotic translation initiation factor 3 subunit E-A
Sequence:
MASRKESAASGSNPLDFPVKQIQVDGLVVLKIIKHYQEEGQGSEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDVEFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVSRALLDSQFSYQHAIEESVVLIYDPLKTAQGSLCLKAYRLTPKLMEICKEKDFTPEGLKKAAVAYEHMFEEVPIFIKNSHLINVLMWDLQEKSTLADKHELLNLSSSNHLEKSLQLLMDRVDDMSQDIVKYNTYCRNLSKQQQQKQQYQQRRQQENAQRQSRGEPPLPEEDISKMFKAPQAPPRMDTLLIAGQINNYCQNIKEFTSQNLGKLFMAEALQSNSS
Protein: Kinesin heavy chain (P48467)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Myosin-2
- Dynactin, 150 kDa isoform
- Kinesin
- Tubulin beta chain
- Kinesin
- Kinesin-like protein
- Nuclear distribution protein nudE homolog 1
- Actin
- Mis6-domain-containing protein
- Kinesin
Sequence:
MSSSANSIKVVARFRPQNRVEIESGGQPIVTFQGPDTCTVDSKEAQGSFTFDRVFDMSCKQSDIFDFSIKPTVDDILNGYNGTVFAYGQTGAGKSYTMMGTSIDDPDGRGVIPRIVEQIFTSILSSAANIEYTVRVSYMEIYMERIRDLLAPQNDNLPVHEEKNRGVYVKGLLEIYVSSVQEVYEVMRRGGNARAVAATNMNQESSRSHSIFVITITQKNVETGSAKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSSHVPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNDAETLSTLRFGMRAKSIKNKAKVNAELSPAELKQMLAKAKTQITSFENYIVNLESEVQVWRGGETVPKEKWVPPLELAITPSKSASTTARPSTPSRLLPESRAETPAISDRAGTPSLPLDKDEREEFLRRENELQDQIAEKESIAAAAERQLRETKEELIALKDHDSKLGKENERLISESNEFKMQLERLAFENKEAQITIDGLKDANSELTAELDEVKQQMLDMKMSAKETSAVLDEKEKKKAEKMAKMMAGFDLSGDVFSDNERAVADAIAQLDALFEISSAGDAIPPEDIKALREKLVETQGFVRQAELSSFSAASSDAEARKRAELEARLEALQQEHEELLSRNLTEADKEEVKALLAKSLSDKSAVQVELVEQLKADIALKNSETEHLKALVDDLQRRVKAGGAGVAMANGKTVQQQLAEFDVMKKSLMRDLQNRCERVVELEISLDETREQYNNVLRSSNNRAQQKKMAFLERNLEQLTQVQRQLVEQNSALKKEVAIAERKLMARNERIQSLESLLQESQEKMAQANHKFEVQLAAVKDRLEAAKAGSTRGLGTDAGLGGFSIGSRIAKPLRGGGDAVAGATATNPTIATLQQNPPENKRSSWFFQKS
Protein: Cold-inducible RNA-binding protein (Glycine-rich RNA-binding protein CIRP) (D6W5Y5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYGKSHSEGATLLWPAVGARFTLVPSPSTLGWTLRPCHCACPEEAHLSSQSHFYRRTQKPNETDQKGKGERGPAGQSARCMCGRRPASLGCGGWLLPGRRPRPGLASGVKLPLVASVPLHCACFLSSATHNE
Protein: Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) (Q08357)
Organism: Homo sapiens (Human)
Function: Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756, ECO:0000269|PubMed:9151850}; Multi-pass membrane protein {ECO:0000269|PubMed:9151850}. Apical cell membrane {ECO:0000250|UniProtKB:Q63488}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 53 member 1
- Regulator of MON1-CCZ1 complex
- Myogenesis-regulating glycosidase
- Sodium-dependent phosphate transport protein 2C
- Sodium-dependent phosphate transporter 1
- Sodium-dependent phosphate transport protein 2B
- Parathyroid hormone
Sequence:
MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
Protein: UBX domain-containing protein 2A (UBX domain-containing protein 4) (P68543)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:Q99KJ0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99KJ0}. Perikaryon {ECO:0000250|UniProtKB:Q99KJ0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99KJ0}. Nucleus {ECO:0000269|PubMed:24625977}. Cytoplasm {ECO:0000269|PubMed:24625977}. Note=Expressed at the axon initial segment. {ECO:0000250|UniProtKB:Q99KJ0}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- NSFL1 cofactor p47
- Tether containing UBX domain for GLUT4
- UBX domain-containing protein 10
- Deubiquitinating protein VCPIP1
- Serine beta-lactamase-like protein LACTB, mitochondrial
- UBX domain-containing protein 6
- UBX domain-containing protein 8
- UBX domain-containing protein 1
- Small VCP/p97-interacting protein
Sequence:
MKDVDNLKSIKEEWVCETGSDNQPLGNNQQSNCEYFVDSLFEEAQKVSSKCVSPAEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELQGIFDKEEVDVKVEDKKNEICLSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNNLSAVPLNNLEPITNIQIWLANGKRIVQKFNITHRVSHIKDFIEKYQGSQRSPPFSLATALPVLRLLDETLTLEEADLQNAVIIQRLQKTASFRELSEH