wanglab/gogpt-training-data huggingface dataset:
Protein: Glucose 1-dehydrogenase (GDH) (GlcDH) (EC 1.1.1.47) (Aldose 1-dehydrogenase [NAD(P)(+)]) (EC 1.1.1.359) (Galactose 1-dehydrogenase) (EC 1.1.1.120, EC 1.1.1.48) (O93715)
Organism: Saccharolobus solfataricus (Sulfolobus solfataricus)
Function: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-galactose, D-xylose and L-arabinose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor. Physiologically, seems to be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
Interaction partners:
Sequence:
MKAIIVKPPNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGTDREIVNGKLTLSTLPKGKDFLVLGHEAIGVVEESYHGFSQGDLVMPVNRRGCGICRNCLVGRPDFCETGEFGEAGIHKMDGFMREWWYDDPKYLVKIPKSIEDIGILAQPLADIEKSIEEILEVQKRVPVWTCDDGTLNCRKVLVVGTGPIGVLFTLLFRTYGLEVWMANRREPTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGADVNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYKTLQEIVHTNKTIIGLVNGQKPHFQQAVVHLASWKTLYPKAAKMLITKTVSINDEKELLKVLREKEHGEIKIRILWE
Protein: Beta-mammal toxin Co3 (C0HLF4)
Organism: Centruroides ornatus (Scorpion) (Centruroides infamatus ornatus)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin acts on human Nav1.2/SCN2A, Nav1.4/SCN4A and Nav1.6/SCN8A voltage-gated sodium channels. Also, it reduces the peak of sodium currents in Nav1.5/SCN5A at all potentials. In vivo, is lethal to mice when intraperitoneally injected at a dose of 5ug. No activity is observed when injected into crickets or woodlice.
Subcellular location: Secreted {ECO:0000269|PubMed:31734253}.
Interaction partners:
Sequence:
KEGYIVNYYDGCKYPCVKLGDNDYCLRECRLRYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCN
Protein: NADH-quinone oxidoreductase subunit I (EC 7.1.1.-) (NADH dehydrogenase I subunit I) (NDH-1 subunit I) (P9WJG9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01351}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01351}.
Interaction partners:
- NADH-quinone oxidoreductase subunit C
- NADH-quinone oxidoreductase subunit N
- NADH-quinone oxidoreductase subunit J
- NADH-quinone oxidoreductase subunit G
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit E
- NADH-quinone oxidoreductase subunit B
- NADH-quinone oxidoreductase subunit K
- NADH-quinone oxidoreductase subunit D
- Possible formate hydrogenase HycE
Sequence:
MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGSMFKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGADNTEEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYEKDRLLAPLLPEMAAPPHPRTPGATDKDYYLGNVTAEGLRGVRESQTTGDSR
Protein: Large ribosomal subunit protein mL66 (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (28S ribosomal protein S18a, mitochondrial) (MRP-S18-a) (Mrps18a) (S18mt-a) (P82919)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:11402041, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein bS1m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL21m
Sequence:
MAALNVLVSGCGRFLRGLLTGPTVTSWARPPARGFREVVEIQEGKTTIIEGRITGTPKESPNPPNPSGQCPICRWNLKHKYSYEDVLLLSQFIRPHGGMLPRSITGLCQEEHRKIEECVKMAHRAGLLPNHRPKLPEGFFPKTRPRLNRYLTRWSPRSVKPIYNKGHRWNKVRMAVGSPLLKDNVSYTGRPLVLYH
Protein: Spartin (Q8R1X6)
Organism: Mus musculus (Mouse)
Function: May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8N0X7}. Midbody {ECO:0000250|UniProtKB:Q8N0X7}. Lipid droplet {ECO:0000250|UniProtKB:Q8N0X7}. Note=Transiently associated with endosomes. Colocalized with IST1 to the ends of Flemming bodies during cytokinesis. {ECO:0000250|UniProtKB:Q8N0X7}.
Interaction partners:
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- Epidermal growth factor receptor substrate 15
- IST1 homolog
- Maspardin
- Atlastin-1
- Magnesium transporter NIPA1
- Seipin
- Spatacsin
- Atlastin-2
- Atlastin-3
Sequence:
MEREPENGEPAEIKIIKEAYEKAFMFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISIAAAEPGHTGPAWEAARQMQQKMKETLQNVRTRLEILEKGLATSLRNDLQDVPKLYPEFPPKDACKKSPEQESVSTAPQRAEVDGSASAACAGPSGAPSALPVPSPSCPAEAPPAYSPQAAEGHYTVSYGTDSGEFSSVGEDFYRNRSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTVGAYMFPDTMLQAAGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNREEDEFQIPGRSSHPSEPPKEASGTDVRQSSSSGSSIDQGSKDARHKGKRGKKTKDSSEEVNLSQIVPCEPSSEEKSKELPEWSEKVAHNILSGASWVSWGLVKGAEFTGKAIQKGASKLRERIQPEEKPVEVSPAVTRGLYIAKQATGGAAKVSQLLVDGVCTVANCVGKELAPHVKKHGSKLVPESLKRDKDGKSALDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTVRYKYGHNAGEATHNAVDSAINVGLTAYNIDNIGIKAMVKKTAKQTGHTLLEDYQIVERPQRESQGGATSTEGRRDIGKQVEEEKPGAGKKDK
Protein: PX domain containing serine/threonine kinase like (H7BYG4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAFMEKPPAGKVLLDDTVPLTAAIEASQSLQSHTIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSVEHAPF
Protein: Dyschronic, isoform H (M9PFJ0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MRLGGSGIPYDGDPLTMSAAGNDYAELCDLGPSRWSARPYGYNATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMAFGMISPPPGSGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSAYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVTADDLEIIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAGGYLDGLRSHLGGLTQRVKSWYWGRPLELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEA
Protein: WD repeat and SOCS box-containing protein 1 (WSB-1) (O54927)
Organism: Mus musculus (Mouse)
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity).
Interaction partners:
- Cullin-5
- Elongin-B
- Elongin-C
- Ubiquitin carboxyl-terminal hydrolase 33
- Homeodomain-interacting protein kinase 2
- Ubiquitin carboxyl-terminal hydrolase 20
- E3 ubiquitin-protein ligase RBX1
Sequence:
MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGGENWTVAFAPDGSYFAWSQGYRIVKLVPWSQCRKNFLLHGSKNVTNSSCLKLARQNSNGGQKNKPPEHVIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEFGHLFPSPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYRG
Protein: Breast cancer anti-estrogen resistance protein 3 homolog (p130Cas-binding protein AND-34) (Q9QZK2)
Organism: Mus musculus (Mouse)
Function: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction. Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS. However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25499443}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Note=Localization to focal adhesions depends on interaction with PTPRA. {ECO:0000269|PubMed:22801373}.
Interaction partners:
- Breast cancer anti-estrogen resistance protein 1
- Enhancer of filamentation 1
Sequence:
MAAGKFASLPRNMPVNHQFPLASSMDLLSSKSPLAERRTDAYQDVSIHGTLPRKKKGPPSIRSCDNAGHSKSPRQSSPLTQDIIQENPLQDRKGENFIFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSLAEGRPDVVKRLSLTTGSSIQAREHSLPRGNLLRNKEKSGSQPACLDHVQDRKALTLKAHQSESHLPIGCKLPPQSPSMDTSPCPSSPVFRTGSEPTLSPALVRRFSSDARTGEALRGSDSQLCPKPPPKPCKVPFLKTPPSPSPWLTSEANYCELNPAFAVGCDRGAKLPMQAHDSHEMLLTAKQNGPSGPRNSGINYMILDGDDQARHWDPLAVQTDEGQEDKTKFVPPLMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDRKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAVELKDAMGDLYAFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASNVSVPLLMPLVTLMERQAVTFEGTDMWENNDESCEILLNHLATARFMAEASESYRMNAERILADFQPDEEMTEILRTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL
Protein: 18.8 kDa class V heat shock protein (18.8 kDa heat shock protein) (OsHsp18.8) (Q7EZ57)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MDYYYPMEEEEEVHERPRFRRPVHPWQWHHWQNLLGLLSSSSPSPATAAAAQRCSHVSWEETAAAHLYSASLPGVRKEEIRVEVEDAMYLVIRTELDDGGDGDGGGGGGRRSFARKFRLPAMVDADGISAEYTHGVLRVTVPRLHTRARPVVNLAGGGGGGGGPACDPVARAA
Protein: Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) (Vascular actin single-stranded DNA-binding factor 2 p44 component) (O35295)
Organism: Mus musculus (Mouse)
Function: Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts.
Subcellular location: Nucleus {ECO:0000269|PubMed:33743134}.
Interaction partners:
Sequence:
MADGDSGSERGGGGGGGGGPGGFQPAPRGGGGGGGGPGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGDEDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED
Protein: Lectin 7 (MtLec7) (Agglutinin LEC7) (G7LII0)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi.
Interaction partners:
- Cell wall hydroxyproline-rich glycoprotein
- Stress up-regulated Nod 19 protein
- Carboxypeptidase
- Kunitz type trypsin inhibitor / Alpha-fucosidase
- Subtilisin-like serine protease
- Dehydration-responsive RD22-like protein
Sequence:
MAINTSRTQILFITIISFLILAQNVNSAAFTVSNFDPYKTNIELEGNAFISDGSIHLTNVIPNSAGRASWGGPVRLWDADTGNLAGFTSVFSFEVAPAGPGLIGDGITFFIAPFNSHIPKNSSGGFLGLFNAETALNTYQNRIVAVEFDSFGGNSGGNPWDPAYPHVGIDVNSIASVTTAPWKTGSILTGFNAIAFVNYEPVEKNLSVVVRYPGGNFVNGTSNSVSFIIDLRTVLPEWVRIGFSGATGQLVELHKILSWTFKSSFQ
Protein: Protein IQ-DOMAIN 28 (AtIQD28) (Q8GZ87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:28115582}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24134884, ECO:0000269|PubMed:28115582}. Note=Associates to cortical microtubules (MTs). {ECO:0000269|PubMed:24134884}.
Interaction partners:
- Protein IQ-DOMAIN 9
- Protein IQ-DOMAIN 33
- Protein IQ-DOMAIN 10
Sequence:
MGKTPGKWIKTLLLGKKSPKSNSDNRSQKLKSAKKEELVESVTEDLSNLTVDPPVVSSQPVPASTAQNVVSPINGDESKDNLESRNDLGEVELEQAAIKVQATFRAHQARRAFRTLKGIIRLQAVIRGHLVRRQAIATYSCIWGIVKFQALVRGQKARSSDIAIQFQKKHMEASDSEVLQSSTCSWMDNPTKFVFVDKLLASSPTALPLKIQYGPEEPNSAKVWLERWTQLQVWSSGSRVPRIEIPKSQSKKRNYQAVVEAEKKRPKRSIKKPSGTTSGTGPSRFTAERNKPKRNVRKASTLSKDPLRNESDKANHNSRKSRSGSKEGSPLEIKDEKPSPSLKRSSLSNGSKKATLRSAEKKKKDIPDSSVQIQPEGKVSENVLEGGDNIEFAEKEKDTTDSVQIESEGKVSGNVLEGGEGENIVFTEKEKDTADPVQIEPERKVLEEGDNIESSGKEKDTGDSVQIESEGKVLEGGDNIEFGEKEKDKADAVPIEFDIVKDEKSPVLDRTEEDELKTAETSDKAEALKCADVKVSSENGNVGSDNTKQSEKRALLPANIDKQDDGLTLSGRKIPSYMAPTASAKARVKGEASPRFAQAKTEINGALRRHSLPSPANGKLSTTTMSPRAQKLLLASAKGSMNGDKSFTSSKDITHKSTRTDWKR
Protein: Probable sugar-binding lipoprotein (O53485)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable sugar-transport integral membrane protein ABC transporter
- Trehalose import ATP-binding protein SugC
- Probable sugar-transport integral membrane protein ABC transporter
- Trehalose transport system permease protein SugB
- Probable sugar-transport integral membrane protein ABC transporter UspB
- Trehalose import ATP-binding protein SugC
- Trehalose transport system permease protein SugA
- Probable sugar-transport integral membrane protein ABC transporter UspA
- Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE
- Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA
Sequence:
MVNKPFERRSLLRGAGALTAASLAPWAAGCAADDDDALTFFFAANPDELRPRMRVVNEFQRRYPDIKVRALLSGPGVMQQLATFCAGGKCPDVLMAWELTYAELADRGVLLDLNTLLARDQAFAAELKSDSIGALYETFTFNGGQYAFPEQWSGNFLFYNKQLFDDAGVPPPPGSWERPWSFAEFLDAAQALTKQGRSGRDRQWGFVNAWVSFYAAGLFAMNNGVPWSVPRMNPTHLNFDHDGFLEAVQFYADLTNKHKVAPSAAEQQSMSTADLFSVGKAGIALAGHWRYQTFDRADGLDFDVAPLPIGPRGRAACSDIGVTGLAIAATSRRKDQAWEFVKFATGPVGQALIGESRLFVPVLRSAINSHGFANAHRRVGNLAVLSEGPAYSEGLPVTPAWEKIAALMDRYFGPVLRGSRPATSLTGLSQAVDEVLRNP
Protein: tRNA threonylcarbamoyladenosine biosynthesis protein TsaB (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaB) (P76256)
Organism: Escherichia coli (strain K12)
Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. In fact, can act as a protease that specifically degrades TsaD in vitro; therefore TsaB may post-translationally regulate cellular pools of TsaD via proteolytic degradation. Does not show sialoglycoprotease activity against glycophorin A.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19376873}.
Interaction partners:
- tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
- tRNA N6-adenosine threonylcarbamoyltransferase
- Threonylcarbamoyl-AMP synthase
- [Ribosomal protein bS18]-alanine N-acetyltransferase
- Bifunctional ligase/repressor BirA
- tRNA
- tRNA-specific adenosine deaminase
- ATP-dependent DNA helicase YoaA
Sequence:
MRILAIDTATEACSVALWNDGTVNAHFELCPREHTQRILPMVQDILTTSGTSLTDINALAYGRGPGSFTGVRIGIGIAQGLALGAELPMIGVSTLMTMAQGAWRKNGATRVLAAIDARMGEVYWAEYQRDENGIWHGEETEAVLKPEIVHERMQQLSGEWVTVGTGWQAWPDLGKESGLVLRDGEVLLPAAEDMLPIACQMFAEGKTVAVEHAEPVYLRNNVAWKKLPGKE
Protein: DNA-directed RNA polymerase II subunit rpb4 (RNA polymerase II subunit B4) (O74825)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MPRAIFEEDAAQLKLGPEFENEDMLTVSEAKILIETVLAQRARETNGEIPMTDVMKKTVAYFNVFARFKTAEATYACERILGNRFHKFERAQLGTLCCEDAEEARTLIPSLANKIDDQNLQGILDELSTLRKFQD
Protein: AT3g02480/F16B3_11 (F16B3.11 protein) (Late embryogenesis abundant protein (LEA) family protein) (Q9M892)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Late embryogenesis abundant protein 7
- Late embryogenesis abundant protein 46
- Transmembrane protein, putative
- At5g38130
- At1g07135
- Late embryogenesis abundant domain-containing protein / LEA domain-containing protein
- Germin-like protein subfamily 1 member 19
- Late embryogenesis abundant protein
- Gb|AAF18257.1 hydroxyproline-rich glycoprotein family)
- Putative germin-like protein subfamily 1 member 9
Sequence:
MDNKQNASYQAGQATGQTKEKAGGMMDKAKDAAASAQDSLQQTGQQMKEKAQGAADVVKDKTGMNKSH
Protein: Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (Q3U0V1)
Organism: Mus musculus (Mouse)
Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.
Interaction partners:
- 14-3-3 protein zeta/delta
- Heterogeneous nuclear ribonucleoprotein D0
- Endoribonuclease Dicer
- Ribonuclease 3
- Poly
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoprotein L
- ELAV-like protein 1
- Poly
- Mitogen-activated protein kinase 14
Sequence:
MSDYNTGGPPPGPPPPAGGGGGAAGAGGGPPPGPPGAGDRGGGGPGGGGPGGGGASGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNNTPDFGFGGQKRQLEDGDQPDSKKLASQGDSIGSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRVGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGAPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFVIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPNKAAAAATDPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPPTQQGQQQASGNCHPPPPPFSFQPPATVHPALVGSAGNPFPCGVCP
Protein: Cytochrome b6-f complex subunit petO, chloroplastic (Cytochrome b6-f complex subunit V) (suV) (Cytochrome b6-f-associated phosphoprotein) (Q9LLC6)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: The cytochrome b6-f complex functions in the linear cross-membrane transport of electrons between photosystem II and I, as well as in cyclic electron flow around photosystem I.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:10748028, ECO:0000269|Ref.2}.
Interaction partners:
Sequence:
MALRCKTPAATCAARSRRSVRVSAHKGAFEQAQVAAAAFVAAAVIAAPANAGVVLQQPVLKKAFQDDTPAAPPPKREFRGLAPPALPQSDAPNVAAEKPKKAEVVESTSGGLDPRSVALPGALALTIGGFVAASKIDGSFNDWFMEAVVRDSNNYAGYEATLKSENGVTFPKVAAGGTKKVKAATGSKKGGFPFGGKK
Protein: Receptor L-domain domain-containing protein (G8B8N3)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MQLKNLLAVSAIAGLASAANNSTLTTATPSINKDCSFSDFTATASSQVSQVAACETAAGNIVINGDAFGSVELTGLQQLYGDLAIRNVTKAQTINAPTLQLVSGDLEINACTVLSNLNLAQLTTVGTLELTALPALESTGLAAGLTSAESIIVSDTGLNHLTGINVYRLKVFNVNNNGDIDSIDSGLKEVTDTLDISYNADKVDVNLDELTSAKNIVLQQVNSFNAPNLTVANGSITVTSSSLEKLELAQLKSVGNAIAINKNEDLEELEFPKLTTIGGALQISDNDNLKSLDAFSEVTQIGGTVNINGSFDNGTFDSLTKVAGGFILKIDGDLSCSAFNKLNTKGDVKGDKFQCQDQQTTSSSSSKKSQSSDSSDSSDSSGSGSDSSSSSNSDSDSSSSDSSSKSNGASSSSKIGLFATVVSIFVGVGAALF