wanglab/gogpt-training-data huggingface dataset:
Protein: STEAP4 metalloreductase (C9JS50)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQVNLFLYIFFCS
Protein: At3g27230 (S-adenosyl-L-methionine-dependent methyltransferases superfamily protein) (Q9LK30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Probable diphthine methyl ester synthase
- F3M18.16
- C-type lectin receptor-like tyrosine-protein kinase At1g52310
- At4g12840
- F-box protein At1g70590
- At4g27620
- MIF4G domain-containing protein
- Pentatricopeptide repeat
- Uncharacterized protein AT4g35690
- Tetratricopeptide repeat
Sequence:
MGSVSLKIGDGTARFRRTSICSSAVNLLMLFSVVTTNLFALYAFSSHSQANSPLLHSSNNISLVSQHLSLILREIDSSQRKLAQMEKQMLGYESIDISRPNIVPELKLFLQRHQLPLGKDSRTGITEMVSSVGHSCGKSTDLLSQYMSYKVFDRCPDDWSLGQKLILRACEPLPRRRCLAKTVQKQDLSKSPDSLWRSVSNKSVNWSGLGCKSFDCLKGKKLSKECVGCFDLGVEKDRFVKVKGKNDFLIDDVLGLGSGKIRIGFDISGGSGTFAARMAEKNVTVITNTLNNGAPFSEFIAARGLFPLFLSLDHRFPFLDNVFDLIHASSGLDVEGKAEKLEFLMFDLDRVLKPRGLFWLDNFYCANDEKKKELTRMIERFGYKKLKWVIGEKADAQVYLSAVLQKPVRA
Protein: Cta26p (A0A1D8PUC0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Tlo9p
- Cta24p
- Tlo1p
- Cta2p
- Tlo11p
Sequence:
MPENLQTRLHNSLDEILKSSGYIFEIIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKFEELKVIEAAARKKREEEAKKKEEEAKKKEEEAKKKAEEAKKKAEEAKKKAEEAKKAEEAKKAEEAVPQKFDNFDDFIGFDINDMQNDDTIDDTIDDTIDETIDETIDDTNDEDMLSNMDYENLDPDETIDEVPATTDSDLDMNNILENNESILDGLNMTFLDNGNNTNHVNEEFDVDGFLNQFGN
Protein: Corticotropin releasing hormone (Q703P0)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Corticotropin-releasing factor receptor 1
- Uncharacterized protein
- Corticotropin-releasing factor-binding protein
- Urocortin
- Urocortin 3
- Corticotropin-releasing hormone 2
- Uncharacterized protein.
- Pro-neuropeptide Y
- Pro-thyrotropin-releasing hormone
- Guanine nucleotide-binding protein G
Sequence:
MKLQPLVCAGILLLALLPCHECRALSKSPGAARGALQQPDFFPQQQQQQQQQTLPVLLRMGEEYFLRLGHLTKRPAGPFSASSGGHLRPEASAELLRAAAAQLQGSGSPEGDEGAGEAVEREKRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
Protein: GH01410p (Q95TD0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQLLITNLWLSLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNR
Protein: Testicular tissue protein Li 206 (A0A024R6I3)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Membrane {ECO:0000256|RuleBase:RU003827}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003827}.
Interaction partners:
Sequence:
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE
Protein: Striatin-4 (Zinedin) (Q9NRL3)
Organism: Homo sapiens (Human)
Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:18782753}.
Interaction partners:
- Programmed cell death protein 10
- Striatin-interacting protein 1
- Striatin-3
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Striatin
- MOB-like protein phocein
- CTTNBP2 N-terminal-like protein
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein kinase 25
- Suppressor of IKBKE 1
Sequence:
MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV
Protein: Flavoprotein monooxygenase, putative (Q38ER6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adrenodoxin reductase, putative
- NADH dehydrogenase flavoprotein 1, mitochondrial
- 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
- Peptidyl-prolyl cis-trans isomerase
- Uncharacterized protein
- NADH-ubiquinone oxidoreductase, mitochondrial, putative
- Complex 1 LYR protein domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- NADH dehydrogenase 1 beta subcomplex subunit 9
Sequence:
MWRRSRFLRGSTNRYTDGSGRRLDSSNIPSDLDLQPISNRAYPVRGEHWQPVLVGEPSPHKGNVIVSGAGTVGMATAAIFALRGWHATVVERQPSVLRMQSATSEGGEILSSYYGSLSAGLQHALITRRAADALQAAGLRVSAFRHCGVPVTGVLDHPGAYNSWFTRGLVEHHPFAVKMLSVNLLALRQVLEKHLHNLPTGNCRVFHQHVVEAVNPLKQQLVVKPISDSNKPLEGARSAVHNGDDNPFSSNEVDKHGMQQGTHMETSLTLHRVKWEKKYANDAVDYDLLVCAEGVNSRLRDLVDVEGFAADVDFGVRWLVLRSRHLSSEHIHRWLHRRKGPAPLHEVCSPHQVPLAIAFPRIPQNKEAPPTARAGDSEADVEATKSFALMLYAPMDDLQRLSDHEALRTFCPDIVQADGSCNATSYAKNVVPFPTIHCENLYNAVGLPSAVVVGDAAHTCNPFWLQGLAMGLEDGVNLLNQVDAYSKHFYDAIKQYSQERGCSGDALRLITDRCLYYERTKHINPLVRFQDSYRRAMNIILPKIMNEYYTGASVNQLYSKSLESMLNGRGYASYEFAEKQQSKHSAFHHIGRVYT
Protein: Unconventional prefoldin RPB5 interactor (Q966M4)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Spindle and kinetochore-associated protein 2
- Prefoldin subunit 2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Probable prefoldin subunit 6
- RuvB-like 1
- Probable prefoldin subunit 5
- RuvB-like 2
- Probable prefoldin subunit 4
Sequence:
MSELYVAECNAAKARLEVETECRRIIADNYEKVLERAKEYSKKLEAPILAKICEVGYFCGAHVVRTNQVTMEMGANYYGECSIHTAEKILDRRVSEMRRQREEGLDSIRMLDDKIKFAQDNFSSVSIDGGPIEIVEKYDEEMEKLFYQNRKNKKMSQNDEQNEKIIEKNKLNGDQDHNDVMNRLEELEKLEQDNDEMEEAPIPKPFEVSNEDLQDLGKLEEVEEVEQDPTDKKLRFGMNERLLAQPGVTQKEMERLLDFLDTCDEESSDEEYDEDEEEGDDDEENLNNSVEELDSDDYASDDNIEKSNNSDQQLKSKKIETQVIKVEEIVEETVTKTTVKRKKSGVRFAQQLENVKTFHQTDTVEIKEEDSVIETKSILRSTEPTPVDRSALEPEQKELAAMSTMTFPGEIVEKNPYECEPSTSRDPAPVITEKKVSKFRASRHRN
Protein: Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase family 3 member A1) (I3L3I9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Protein: Protein jagunal homolog 1 (Q5XKN4)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK
Protein: Temporin-SN4 (E7EKM1)
Organism: Sylvirana spinulosa (Fine-spined frog) (Hylarana spinulosa)
Function: Antimicrobial peptide. Active against some Gram-positive and Gram-negative bacterial strains. Active against fungus C.glabrata 090902 but not against C.albicans ATCC 12231. Shows weak hemolytic activity against human erythrocytes.
Subcellular location: Secreted {ECO:0000305|PubMed:24055160}.
Interaction partners:
Sequence:
MFTLKKTLLLLFFLGTINLSLCEEERNAEEERRDGDDEMDVEVKKRFITGLISGLMKALGK
Protein: Agrin (A0A0R4IJ40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Muscle, skeletal receptor tyrosine-protein kinase isoform 3 precursor
- Dystroglycan 1
- Low density lipoprotein receptor-related protein 4
- 43 kDa receptor-associated protein of the synapse
- Docking protein 7.
- Transmembrane serine protease 15
- Heparan sulfate proteoglycan 2.
- Fukutin.
- Protein O-mannosyl-transferase 1
- Nidogen 2b
Sequence:
MTSCQYPTPPPERDRMYQHKVSLVVRYFMIPCNICLILLATSTLGFAVLLFLNNYKPVHFTPAPPPDGCRGKLCGFGAVCERDQADPSKGECVCKKIVCTSVVAPVCGSDSSTYSNECELEKAQCNTQRRIKVMRKGPCALKDPCSEVTCSFGSTCIQSSDGLSAKCMCPLSCENVPKHVVCGSDGLDYQSECELNMKACATQKNIRVHHQGRCDPCSDTLNSLSTACRVNPKTYQQITFAPAESCPPDEMPICASDGHTYESMCQMERTALKNNLELKKVSLGSCKEKGGCPNGCKFNAICLLDNGEFRCSCDPIQCDGTYKPLCGKDGKTYPNDCERKLQECRTQKDIPVKQQGPCDLNLESPCLKKTCEFGAVCVVKNSEAVCECSDACPQDQDPVCGSDGHTYSSSCQMKAMGCALQKQIQMQHKGPCADESCTNCSFGAICDAQTGRCVCPKGCLETRQPVCGSDGTTYDNECKLNVQACTKQLDLKVVAHGECKTCGSTVCSWGSQCVNNKCECQQCTGQPVKPVCGSDGNTYNNDCELRLASCQKQRKIEVAKPGVCDEDCGSGGSGSGSETCEQDRCRRYGGTWDDDMEDERCVCELNCQIVLHSPVCGSDGNTYSSDCELKKTRCEKQIDLSVQSQGPCPTIVSPPPELVASQHCSQTVYGCCEDNKTAALGVGLAGCPSMCQCNHYGSYGGTCDPSTGQCSCKPGVGGLKCDRCEPGFWNFRGIVTENMSGCTPCNCDGVGSVRDDCEQMSGLCSCKPGVKGMKCNVCPDGSKMGVNGCDKGPKAPKSCAELVCHFGSSCVEVNGQAHCECPSPDCDEKNKTKVCGSDGVTYADRCQLKTIACRQDKEIKVEHLGQCKESIELTAKPTPFPTTHRTTPPTAHVKVTKQRHGHRTTTPDSYVVEAMPPPRLDGARKFSSPFTTHRPTTPYKPLRTSSPPLDFDESGSGEPSGDDEMVSGMEESGEEPLGTTVATTTLPTAEERSSCDNTAFGCCPDGKTAAVNSEGTNCPSTMRFSGFLHLDKVEGQEVFYTPEMEDPKSELFGETARSIESAMNELFRKSDVQKDFQSVRVRNLSPSNSIIAHFEAHFDPDTRFNVGDIEGALLKQLKASKDTGIVVKKPEEENIRINNYGLSTVPFFTTTTTTVASVTTPTTTTTTMSPSSAYTTLRPITTRRPFTRTTTPAPATTTAPHVPKTTVSLMNRLGPHAHSPCDSQPCRHGGTCEEDDNDFTCICPAGRGGAVCEKVIKYFIPSFGGKSYMAFQTMKAYHTVRIAMEFRASEMTGILLYNGQKSKKDFLSLTLVEGYVELRFNTGSGTASVISKVLVKPGRWHQLVVVRNRRNAMLSVDNEPSVEGQSPPGTDGLNLDTDLFIGGVLDDMSADVKERTSVSAGLVGCIRMLDVNNLVYNLQENGGSVLYGSAIGECGNNPCLPNPCKNGASCQVKEAEIFHCKCVNGFSGPTCADAHNPCDPNKCHPPSRCQVLPEGGYKCECPMGREGRHCEKVSDKGGAFIPYFTGDSFLELKGLHTYNQDLRQKFSMTIVLLANDSKGMIFYNGQKTDGKGDFISLSLNDGILEFRYDLGKGPAVIRSKEKIKLNEWNTVNLERASRKGEISINGKDPVRGEAPNQHTDLNLKESLFVGGAPDFRKVARAAAIKDGFKGAIQKITLMGIPILKADNALSSTDVSMYPNHPCSKDVCENGGRCNPQLNSYECACRHGFSGHHCQDTIFEKSAGDTEAIAFDGHTFIEYHNGVTKSEKALLVNKFELSIRTEATHGLILWSGKGVERSDYIALAIVDGRVQMTYDLGSKPVVLRSTVRVNTNHWIRIKASRALRDGSLQVGNEAAVTGSSPLAATQLDTDGALWLGGLEELSVARRLPKAYSTGFIGCVKDVIVDGVELHLVEDALNTPKISHCSAK
Protein: Mitochondrial adapter protein MCP1 transmembrane domain-containing protein (Q5AGY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Vacuolar protein sorting-associated protein
Sequence:
MSQEDLLTRVTPVPLDEIEDTNPIIPKRKHWLVPTLYRIQKYSAYSFISFLGIHATSVILVPILPIDQSIKDEVFAMAKEVYQSVPLYEPICIIGSVAAHVMAGISIRIYKKCFQKKPSHHINNGRHSPITNKLEDHDDEIGFGGISNLFGLGYRKSFTVQFGLTPLQFSGYVLIPFFIYHMYKFRYIPWINDGDSSLINLEYISYVLNLKHPMWNVFALGTLIYSMSYHGTNGLMKLKGKYSKTWKKIGLAVVNGVSLLGWISVYLFKCNVEVIDVNGFLGKSFTKYLRSFWL
Protein: Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1) (O70281)
Organism: Mus musculus (Mouse)
Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O60507}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O60507}.
Interaction partners:
- Coagulation factor VIII
- Podocalyxin-like protein 2
- Gastrin
Sequence:
MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPARLENPKATVRAGLDIKANKTFTYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEVIVKHGEPAPYLCNKDPFALKSLTYLARLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLHIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKILENTRRVYKGEFQLPDFLKEKPQTEQVE
Protein: Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) (Q8ND76)
Organism: Homo sapiens (Human)
Function: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}; Lipid-anchor {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}; Cytoplasmic side {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Interaction partners:
- Cyclin-dependent kinase 14
- Cyclin-dependent kinase 16
- G2/mitotic-specific cyclin-B3
- Cyclin-dependent kinase 15
- Cyclin-Y-like protein 1
Sequence:
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
Protein: Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) (Q96JC1)
Organism: Homo sapiens (Human)
Function: Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.
Subcellular location: Cytoplasm. Lysosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:23167963}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Late endosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:23167963}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. {ECO:0000269|PubMed:12941698}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. {ECO:0000269|PubMed:33422265}.
Interaction partners:
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 33A
- Vacuolar protein sorting-associated protein 18 homolog
- Syntaxin-17
- Vacuolar protein sorting-associated protein 33B
- Transforming growth factor-beta receptor-associated protein 1
- Vacuolar protein sorting-associated protein 8 homolog
- Vesicle-associated membrane protein 8
Sequence:
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
Protein: Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) (P21265)
Organism: Gallus gallus (Chicken)
Function: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Adenylosuccinate synthetase isozyme 2
- Bifunctional purine biosynthesis protein ATIC
- Adenylosuccinate synthetase isozyme 1
- Trifunctional purine biosynthetic protein adenosine-3
- Multifunctional protein ADE2
- Amidophosphoribosyltransferase
- Uncharacterized protein.
- Uncharacterized protein.
- Adenylate kinase isoenzyme 6
Sequence:
MATPCAEEDPLARYRSPLVSRYASAEMGFNFSERKKFGTWRRLWLYLAQAEKSLGLPITDEQIKEMEANLDNIDFKMAAEEEKKLRHDVMAHVHTFAHCCPKAAAIIHLGATSCYVGDNTDLIVLRDGFNLLLPKLARVISRLADFAETHADLPTLGFTHYQPAQLTTVGKRCCLWIQDLCMDLQNLERARDDLRFRGVKGTTGTQASFLQLFEGDHSKVEELDRLVTAKAGFKRSYMVTGQTYSRKVDIEVLSVLASLGASVHKICTDIRLLANLKEIEEPFEKDQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDPLQTASVQWFERTLDDSANRRVCLAEAFLTADIILSTLQNISEGLVVYPKVIDRRIRQELPFMATENIIMAMVKAGGNRQDCHEKIRVLSQQAAAVVKQEGGDNDFIARVRADPYFSPIHEHLDSLLDPSSFTGRAPQQVAKFLKEEVRPALIPYQSMMGGKIELTL
Protein: Alkaline phosphatase (EC 3.1.3.1) (F8VPQ6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
Interaction partners:
- Thiamine pyrophosphokinase 1
- GTP cyclohydrolase 1
- 6-pyruvoyl tetrahydrobiopterin synthase
- Cancer-related nucleoside-triphosphatase homolog
Sequence:
MQGDWVLLLFLGLRIHLSFGIIPAEEENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPLAMDLFPYMALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGLSAAARLDQCNTTFGNEVFSVMYRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDAEMPASALQDGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPSDSNQSGTRLDDQNLVQTWLSKHQGARYVWNRSELIQASQDPAVTHLMGLFEPTEMKYDANRNPSVDPSLAEMTEVAVRMLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLILITADHSHVFAFGGYTLRGTSIFGLAPLKALDDKSYTSILYGNGPGYELKSGNRPNVTEAQSVDPNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPAGQSPVITPGQATTTNNAAGQATTTNNAAGQATVLLSLQLLVSMLLLVGTAMVVS
Protein: Putative mismatch repair protein PMS1 (Q9BLY2)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MITLLDEGSSRKLSAGQVITNLSSVVKELVENSLDAGARTVAIRVEDSGAGNITVEDDGSGMDLSYLLDSEGRLKEDASLPLLASRATTKRRGGDSGLSSQAAQTLGFRGEALHSLAHLSELSICTMSESTRPTALLIAYDSNSRRTTVKVTSERRDVGTTVVVSKLFAALPVRHKDFVRGRKKQLLAATLLMKQYALSHPHVRLLMTHRAGPDSAPVTLVSLTGTGDPQRALAEAYGGRVIANMERVEWELTFGTITGYVSKGNAGRLSSDMQVFALDGRLVDLPMMAKAVNDAYAESLPNAAQRTFPAFFLHVSSGESLPYDVNLVPDKRKVLISDEERHAGEVRTCGLRTFQASTDGIDLPVRNEGGWRHVPERRNTQETMPTQTPLSATSIAQFIYQRRETSQGDNLIDNAAVAQVQPSVCLSQLLSGSSPIGRTSSPDATASPTSTTNRAPSERSAGSVESVLEYPLTFEPTQKRQRLESSAEEGNTGDTDGSSWGEEDPRELGPEEMMGTDDAVVNYVTDDTNQQRPGPPRSSVRFPPFSVLAEMPLVHSLGEWAAPSQPSDGGGVRKFSRLQKQTEEELTLYLGKESFKNMVVHGQFNHGFIVTSLDDNIFVIDQHAADEKGNYEHLMSHYVARPQPLFSPVPVSMEPQAVDLAVDHAEELRQHGFIVQRSDDTNKLLVLSVPVIPYEVVDPQNVVELIRQLVHYNTISKPMRCVWHSMATKACRSSIMVGTMLSEKKMRSVVDRMGELEQPWNCPHGRPTVRHVSKISSLVSLMTKSRRA
Protein: Forkhead box protein B1 (Transcription factor FKH-5) (Q99853)
Organism: Homo sapiens (Human)
Function: Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium. Essential for the mammillary nuclei maintenance. Negatively regulates the proliferation of oligodendrocyte progenitors and promotes oligodendrocyte maturation. Also expressed in mammary glands, plays a role in lactation, controls development of mammary glands and the inferior colliculi of the midbrain in the central nervous system that regulates the milk-ejection reflex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q64732}.
Interaction partners:
Sequence:
MPRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKVLKSDHLAPSKPADAAQYLQQQAKLRLSALAASGTHLPQMPAAAYNLGGVAQPSGFKHPFAIENIIAREYKMPGGLAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVYGSAGMIDSATPISMASGDYSAYGVPLKPLCHAAGQTLPAIPVPIKPTPAAVPALPALPAPIPTLLSNSPPSLSPTSSQTATSQSSPATPSETLTSPASALHSVAVH
Protein: Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit [Includes: Biotin carboxylase (BC) (EC 6.3.4.14); Biotin carboxyl carrier protein (BCCP)] (P96890)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, resulting in the formation of carboxyl biotin. When associated with the beta5 subunit AccD5, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for propionyl-CoA. When associated with the beta6 subunit AccD6, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for acetyl-CoA. When associated with the beta4 subunit AccD4, the beta5 subunit AccD5 and the epsilon subunit AccE5, forms the LCC complex, which is involved in the carboxylation of long chain acyl-CoA. The LCC complex can use C16-C24 substrates, the highest specific activity is obtained with carboxy-C20-CoA.
Interaction partners:
- Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit
- Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit
- Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit
- Biotin-dependent long chain acyl-coenzyme A carboxylase beta4 subunit
- Probable fatty acid synthase Fas
- Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase epsilon subunit
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase beta1 subunit
- Malonyl CoA-acyl carrier protein transacylase
- Biotinylated protein TB7.3
- Biotin--[acetyl-CoA-carboxylase] ligase
Sequence:
MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK