wanglab/gogpt-training-data huggingface dataset:
Protein: Ethylene-responsive transcription factor 10 (AtERF10) (Ethylene-responsive element-binding factor 10) (EREBP-10) (Q9ZWA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mitochondrial transcription termination factor family protein
Sequence:
MTTEKENVTTAVAVKDGGEKSKEVSDKGVKKRKNVTKALAVNDGGEKSKEVRYRGVRRRPWGRYAAEIRDPVKKKRVWLGSFNTGEEAARAYDSAAIRFRGSKATTNFPLIGYYGISSATPVNNNLSETVSDGNANLPLVGDDGNALASPVNNTLSETARDGTLPSDCHDMLSPGVAEAVAGFFLDLPEVIALKEELDRVCPDQFESIDMGLTIGPQTAVEEPETSSAVDCKLRMEPDLDLNASP
Protein: GRF-interacting factor 1 (OsGIF1) (Protein ANGUSTIFOLIA 3 homolog) (Protein MAKIBA 3) (Q6AVI1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription coactivator that plays a role in the regulation of meristematic function in leaves, stems and inflorescences. May regulate leaf size, length of stem internodes, and seed size by promoting cell expansion (Probable). Transcription coactivator that plays a role in the regulation of grain size. Component of a network formed by the microRNA396 (miRNA396), the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (Probable). Component of the miRNA396c-GRF4-GIF1 regulatory module that plays an important role in grain size determination.
Subcellular location: Nucleus {ECO:0000269|PubMed:29051769}. Cytoplasm {ECO:0000269|PubMed:29051769}. Note=Localizes predominantly in the nucleus. {ECO:0000269|PubMed:29051769}.
Interaction partners:
- Growth-regulating factor 1
- Os04g0382100 protein
- Os07g0609766 protein.
- Actin-related protein 4
- Growth-regulating factor 4
- Os02g0723700 protein
- Expressed protein
Sequence:
MQQQHLMQMNQGMMGGYASPTTVTTDLIQQYLDENKQLILAILDNQNNGKVEECARNQAKLQHNLMYLAAIADSQPPQTAAMSQYPSNLMMQSGARYMPQQSAQMMAPQSLMAARSSMMYAQPALSPLQQQQQQQAAAAHGQLGMGSGGTTSGFSILHGEASMGGGGGGGGAGNSMMNAGVFSDFGRGGGGGGKEGSTSLSVDVRGANSGAQSGDGEYLKGTEEEGS
Protein: E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) (Q9H000)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9ERV1}. Nucleus {ECO:0000250|UniProtKB:Q9ERV1}.
Interaction partners:
- Polyadenylate-binding protein-interacting protein 1
- Hydroxyacylglutathione hydrolase, mitochondrial
Sequence:
MSTKQITCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWDFIENRESRHVPNNEDVDMTELGDLFMHLSGVESSEP
Protein: Fatty-acid and retinol-binding protein 1 (Ls-FAR-1) (Q8WT56)
Organism: Litomosoides sigmodontis (Filarial nematode worm)
Function: Binds retinol and different fatty acids.
Subcellular location: Secreted {ECO:0000269|PubMed:12106870}.
Interaction partners:
Sequence:
MYHQLILMALIGVIMANVVPFSMSNIPEEYKEFIPEEVKNFYKNLSIFLCQILRELASKHATFTNEDAALEALKNKSDKLYQKAVELRNFVKAKIDSLKPDAKAFVDEIIAKVRSLRPEDGQKLDMEKLKQAARDIIAKYEALNEETKEELKATFPNTTKIITNEKFKRIANSFLQKN
Protein: Putative Wilms tumor upstream neighbor 1 gene protein (WIT-1) (Wilms tumor-associated antisense RNA) (Q06250)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQRRGQPLENHVALIHWQSAGIPASKVHNYCNMKKSRLGRSRAVRISQPLLSPRRCPLHLTERGAGLLQPQPQGPVRTPGPPSGSHPAAADN
Protein: Ethylene-responsive transcription factor ERF073 (AtERF73) (Protein HYPOXIA RESPONSIVE ERF 1) (Q8H0T5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in the hypoxic stress response. Acts as a transcriptional activator via the cis-acting element GCC box. Plays a role in low oxygen signaling and contributes to tolerance to anoxia stress by enhancing anaerobic gene expression and ethanolic fermentation. Invovlved in the modulation of ethylene responses under both normoxia and hypoxia.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366, ECO:0000269|PubMed:20113439}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:24728113}.
Interaction partners:
Sequence:
MCGGAVISDYIAPEKIARSSGKSSWRSNGVFDCSIYDFDGNFDELESDEPFVFSSTHKHHASGSASDGKKKQSSRYKGIRRRPWGRWAAEIRDPIKGVRVWLGTFNTAEEAARAYDLEAKRIRGAKAKLNFPNESSGKRKAKAKTVQQVEENHEADLDVAVVSSAPSSSCLDFLWEENNPDTLLIDTQWLEDIIMGDANKKHEPNDSEEANNVDASLLSEELLAFENQTEYFSQMPFTEGNCDSSTSLSSLFDGGNDMGLWS
Protein: Auxin response factor 5 (Auxin-responsive protein IAA24) (Transcription factor MONOPTEROS) (P93024)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity.
Subcellular location: Nucleus.
Interaction partners:
- Auxin-responsive protein IAA17
- Auxin-responsive protein IAA12
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA1
- Auxin-responsive protein IAA3
- Auxin-responsive protein IAA14
- Auxin-responsive protein IAA8
- Auxin transporter protein 1
- Auxin-responsive protein IAA9
- Auxin-responsive protein IAA6
Sequence:
MMASLSCVEDKMKTSCLVNGGGTITTTTSQSTLLEEMKLLKDQSGTRKPVINSELWHACAGPLVCLPQVGSLVYYFSQGHSEQVAVSTRRSATTQVPNYPNLPSQLMCQVHNVTLHADKDSDEIYAQMSLQPVHSERDVFPVPDFGMLRGSKHPTEFFCKTLTASDTSTHGGFSVPRRAAEKLFPPLDYSAQPPTQELVVRDLHENTWTFRHIYRGQPKRHLLTTGWSLFVGSKRLRAGDSVLFIRDEKSQLMVGVRRANRQQTALPSSVLSADSMHIGVLAAAAHATANRTPFLIFYNPRACPAEFVIPLAKYRKAICGSQLSVGMRFGMMFETEDSGKRRYMGTIVGISDLDPLRWPGSKWRNLQVEWDEPGCNDKPTRVSPWDIETPESLFIFPSLTSGLKRQLHPSYFAGETEWGSLIKRPLIRVPDSANGIMPYASFPSMASEQLMKMMMRPHNNQNVPSFMSEMQQNIVMGNGGLLGDMKMQQPLMMNQKSEMVQPQNKLTVNPSASNTSGQEQNLSQSMSAPAKPENSTLSGCSSGRVQHGLEQSMEQASQVTTSTVCNEEKVNQLLQKPGASSPVQADQCLDITHQIYQPQSDPINGFSFLETDELTSQVSSFQSLAGSYKQPFILSSQDSSAVVLPDSTNSPLFHDVWDTQLNGLKFDQFSPLMQQDLYASQNICMSNSTTSNILDPPLSNTVLDDFCAIKDTDFQNHPSGCLVGNNNTSFAQDVQSQITSASFADSQAFSRQDFPDNSGGTGTSSSNVDFDDCSLRQNSKGSSWQKIATPRVRTYTKVQKTGSVGRSIDVTSFKDYEELKSAIECMFGLEGLLTHPQSSGWKLVYVDYESDVLLVGDDPWEEFVGCVRCIRILSPTEVQQMSEEGMKLLNSAGINDLKTSVS
Protein: RAB11A, member RAS oncogene family (cDNA FLJ57160, highly similar to Ras-related protein Rab-11A) (B4DQU5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTRDDEYDYLFKVVLIGDSGVGKSNLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
Protein: Protein YIF1B (YIP1-interacting factor homolog B) (Q5BJH7)
Organism: Homo sapiens (Human)
Function: Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Note=Shuttles between the endoplasmic reticulum, the intermediate compartment and the Golgi apparatus. {ECO:0000269|PubMed:26077767}.
Interaction partners:
- Protein YIPF5
- Protein YIPF7
- Mediator of DNA damage checkpoint protein 1
- Prenylated Rab acceptor protein 1
Sequence:
MHPAGLAAAAAGTPRLRKWPSKRRIPVSQPGMADPHQLFDDTSSAQSRGYGAQRAPGGLSYPAASPTPHAAFLADPVSNMAMAYGSSLAAQGKELVDKNIDRFIPITKLKYYFAVDTMYVGRKLGLLFFPYLHQDWEVQYQQDTPVAPRFDVNAPDLYIPAMAFITYVLVAGLALGTQDRFSPDLLGLQASSALAWLTLEVLAILLSLYLVTVNTDLTTIDLVAFLGYKYVGMIGGVLMGLLFGKIGYYLVLGWCCVAIFVFMIRTLRLKILADAAAEGVPVRGARNQLRMYLTMAVAAAQPMLMYWLTFHLVR
Protein: O-methyltransferase VdtC (EC 2.1.1.-) (Viriditoxin biosynthesis cluster protein C) (A0A443HJY8)
Organism: Byssochlamys spectabilis (Paecilomyces variotii)
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of viriditoxin, one of the 'classical' secondary metabolites produced by fungi and that has antibacterial activity. The first step is performed by the polyketide synthase VdtA which condenses one acetyl-CoA and 6 malonyl-CoA units to form the heptaketide monomer backbone of viriditoxin. The product of VdtA is then O-methylated on C7 by the O-methyltransferase VdtC. The O-methyl group is important for the stereoselective coupling of the monomers at the final step of viriditoxin biosynthesis. The short-chain dehydrogenase/reductase VdtF then acts as a stereospecific reductase converting the pyrone to dihydropyrone via the reduction of the C3-C4 double bond. The FAD-binding monooxygenase VdtE then converts the ketone group into a methyl-ester group to yield semi-viriditoxin. Finally, the laccase VdtB is involved in dimerization of 2 semi-viriditoxin molecules to yield the final viriditoxin. VdtB is responsible for the regioselective 6,6'-coupling of semi-viriditoxin, which yields (M)-viriditoxin and (P)-viriditoxin at a ratio of 1:2. The non-catalytic carboxylesterase-like protein VdtD affects the stereochemistical outcome of the coupling. The highly reducing polyketide synthase VdtX is not involved in viriditoxin synthesis, but might possibly play a role in the production of additional metabolites not identified yet.
Interaction partners:
- N-acetyltransferase domain-containing protein
- Acyl-CoA N-acyltransferase
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase
- S-adenosyl-L-methionine-dependent methyltransferase
- O-methyltransferase-domain-containing protein
Sequence:
MAEEIKLTPLETFAQAISASAKTIATYCRDSGHPQLSDDNSSGLTGDVLPPSAPQAVTAARQTILEASYRLQQLVTEPSQYLPRLTVYPQHLAALRWLCHFRIPELIPVQGTRTYYELATEAKVPLHQLQSIARMAITGSFLREPEPNIVAHSRTSAHFVENPSLRDWTLFLAEDTAPMAMKLVEATEKWGDTRSKTETAFNLALGTDLAFFKYLSSNPQFTQKFSGYMKNVTASEGTSIKHLVNGFDWASLGNAIVVDVGGSTGHASIALAESFPDLKFIVQDLPMVTSTSKDNREKTPLPETVASRISFESHDFFKPQPVQNADVYLLRMILHDWSFKEAGEILANLVPSVKQGARILIMDTVLPRHGTVPVTEEALLRVRDMTMMETFNSHEREIDEWKDLIQGVHTGLRVQQVIQPAGSSMAIIEVVRG
Protein: Cysteine/O-acetylserine efflux protein (P38101)
Organism: Escherichia coli (strain K12)
Function: Exporter of O-acetylserine (OAS) and cysteine.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:12562784, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable amino-acid metabolite efflux pump
Sequence:
MTPTLLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIVWLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKIILYGVTALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAGHLFQRLFRQYGRQLNIVLALLLVYCAVRIFY
Protein: HTH-type transcriptional regulator CymR (Cysteine metabolism repressor) (O34527)
Organism: Bacillus subtilis (strain 168)
Function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.
Interaction partners:
- Cysteine synthase
- Putative cysteine desulfurase IscS 1
- Uncharacterized methyltransferase YrrT
- Peroxide operon regulator
- HTH-type transcriptional regulator CysL
- Cystathionine gamma-lyase
- tRNA-specific 2-thiouridylase MnmA
Sequence:
MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQLVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRELWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI
Protein: Galactokinase (EC 2.7.1.6) (Galactose kinase) (Q9HDU2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Bifunctional protein gal10
- UDP-glucose 4-epimerase uge1
- Multifunctional tryptophan biosynthesis protein
- Probable D-xylose 1-dehydrogenase
- Uncharacterized protein PB2B2.11
- Alpha-galactosidase mel1
- Phosphoglycerate kinase
- Dihydroorotate dehydrogenase
- Triosephosphate isomerase
Sequence:
MATVPTYHDLSFYSNPKENKARYAKLLNSFEQKYHCKPDFFSRSPGRVNIIGEHIDYNYFSVLPMAIDVDVIVSVTTSDDAKVELNNTNPEFKEEILELPSDGAVIEINKTHHTWGNYFRCSMIVAHKYILEKYPELVSGGKKPLKGLKLIFDGNVPTGGGLSSSAAFCVASILAILKANGINTITKEDLVKISVVSEHYVGVNTGGMDQCASIYGEQNKALLVQFKPKLMATPFKMPVLKPHDMVFLISNTLVEANKQETALTNYNLRVVEMAVASEFLAKKFNLELPKESNLHTGTLRGFMDEYYEKHLKQPHWDGSDIDMGVQRMQEMLRLTEIMFSEEQKVGFKTEELAKELGLSVEEFTKVFLTKIPVKYERMKIYQRTVHVYSDAMRVLQVLKLFHQHKDSDDPQKFMLAFGRLLNDSQRSEDIYNNSSSPELREVCKISLANGGYGARTTGAGWGGSAVHLTTHDKLAKLVEALTEQYYKKQFPKITQSELNAAVVVSKPAAGSCIVQLAEY
Protein: Membrane-spanning 4-domains subfamily A member 3 (Hematopoietic-specific transmembrane protein 4) (HTm4) (Q920C4)
Organism: Mus musculus (Mouse)
Function: Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Myeloperoxidase
- Cathepsin G
- Neutrophil elastase
- Membrane-spanning 4-domains, subfamily A, member 18
Sequence:
MKPEETGGSVYQPLDESRHVQRGVLQALGAIQILNGILILALGIFLVCLQHVSHHFRHFFFFTFYTGYPLWGAVFFISSGSLTVAAGRNPTRMLMQNSFGINIASTTIAFVGTVFLSVHLAFNTQAFKGCQSSPSPDVCISLGSSSDGLVSLMLILTLLELSVTISISAMWCLGNVCGLREAITSPPNSVESGILPEGSDSENLNTQPQASEE
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (A0A494C0Q2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSDKPRQHSFQMDNQKRELINQDESVIRNQ
Protein: tRNA (uracil(54)-C(5))-methyltransferase (EC 2.1.1.35) (PabTrmU54) (tRNA(m5U54)-methyltransferase) (RUMT) (Q9UZR7)
Organism: Pyrococcus abyssi (strain GE5 / Orsay)
Function: Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA.
Interaction partners:
- tRNA
Sequence:
MRGVIRKLNDDGFGVLKGILVPFSAPGDEIIVERVERVKKRRVASQWKLVRSSPLRVGPRCKAFGKCGGCTLQHLNYDYQLEFKRKKLKRILGFEVEVVPSPKIFGHRNRIDLAITKDGIGFRERGKWWKIVDIDECPVFGKTSREAIERLKEFIEEEKISVWNIKKDEGFLRYMVLREGKFTEEVMVNFVTKEGNLPDPTNYFDFDSIYWSVNRSKSDVSYGDIERFWGKEFIRERLDDVDYLIHPNSFFQTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGFNVKGFDSNEFAIEMARRNVEINNVDAEFEVASDREVSVKGFDTVIVDPPRAGLHPRLVKRLNREKPGVIVYVSCNPETFARDVKMLDYRIDEIVALDMFPHTPHVELVAKLV
Protein: Aladin (Q9W351)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in mitotic spindle assembly.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9NRG9}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26246606}. Note=During mitosis localizes throughout the spindle, is excluded from chromatin, and is enriched on the nuclear envelope remnants that surround the spindle. Present in a ring that surrounds the centrosome in prometaphase and metaphase cells. {ECO:0000269|PubMed:26246606}.
Interaction partners:
- Nuclear pore complex protein Nup154
- Nucleoporin Nup188
- Nuclear pore complex protein Nup205
- Nuclear pore complex protein Nup88
- Nucleoporin seh1
- Nuclear pore complex protein Nup75
- Nucleoporin 43kD
- Nucleoporin Nup35
- Nuclear pore complex protein Nup214
- Nuclear pore protein
Sequence:
MAALSNLKQCPPFSTLPDLALRHNHIPELERYPQINLNSELLANPAGQRYYGGQSFVSVNEGVLKRIARSFFNGGFWKTLEEARSPETREQAPLIAQAGDLIAQFLGLATGLRILPHTQQLSAERIAQFVETRDWLNSDVRYLAWNQHFFCLAVAGVDDVVRIYTKSSSATTATVLKSPSQTQITCMAWRPLCASEIVIGCRQGLCFWEVDSTLHLGRTNAPSEIFKYPNNLPITSMQWNKDGTQLATASIGDRSIIIWQPDTGMMQPLKRLGPPGSLLKWSPDNDWLFAATVDRVFRVWNCHQQWTTERWVCGPGGYVQTACWSPCGRFLLFVSSAEPILYRLQFVQQSLLSSSADEKEILPIADLNACSIDANRTLVGGPAQQLAWDPHGNYLVVTFKATNCIAVFRTFIQKFDLQISAAYYLSGETAAEHPSFICFQPLYEDNDRSVLTIAWSSGRIQYYAFD
Protein: Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) (Q6ZPR5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25180167}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NXE4}; Single-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:31142202}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25180167}.
Interaction partners:
- Sphingomyelin phosphodiesterase 3
- Sphingomyelin phosphodiesterase 2
- Sphingomyelin phosphodiesterase
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase 7.
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Sphingolipid delta
- Sphingolipid delta
- Ceramide synthase 2
- Ceramide synthase 4
Sequence:
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
Protein: Uncharacterized protein (C8VPT8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MKFTTGFFTLALAYSAFAEPIPKAKRALSDYTGVFDAIGAQVATVSSTVASYVAGSTSGSAVQDASTELVTIINDGAASVAGFDSLTSLEALQLVAPIQDLTGDISDLIDAVIAAEPNFVADGLDGDVLTSLQDQKAAAEGLRDAITPKVPAALEDIANELSEGIVAEIDRGIAAYSD
Protein: G2/mitotic-specific cyclin-B2 (P29332)
Organism: Gallus gallus (Chicken)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Interaction partners:
- Cyclin-dependent kinase 1
- Cell division cycle protein 20 homolog
- Serine/threonine-protein kinase PLK
- Cell division cycle protein 27 homolog
- DOC domain-containing protein.
- Anaphase promoting complex subunit 4.
- Rhodanese domain-containing protein.
- Extra spindle pole bodies like 1, separase.
- Fizzy-related protein homolog
- Cyclin-dependent kinase 2
Sequence:
MALTRRAAVMRGVENAVTGHNTKAKVQVTGKRAVLEEIGNKVARGSNVPKKTDCIKPPVKATKGPGKMTNTVVPPKPPAAVNQAVKDTTTASKVLSPVPMDVSMQEEDLCQAFSDVLLHNIEDIDADDSGNPQLCSDYVKDIYLYLRQLELQQSVRPHYLDGKTINGRMRAILVDWLVQVHSRFQLLQETLYMCVAVMDRFLQSHPVPRKRLQLVGVTALLLASKYEEMYSPDIADFVYITDNAYNSAEVREMEITILKELNFDLGRPLPLHFLRRASKAGEADAEQHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLGHDKWGTKQQYYTGYAEDSLAMTMKHMAKNVVKVNENLTKYTAVRNKYASSKLLRISTISQLNSKTIKDLAASLL
Protein: Peroxidase 30 (Atperox P30) (EC 1.11.1.7) (ATP7a) (PRXR9) (Q9LSY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Interaction partners:
- Putative cadmium/zinc-transporting ATPase HMA4
- Cinnamyl alcohol dehydrogenase 5
- UDP-glycosyltransferase 72E2
- Probable cinnamyl alcohol dehydrogenase 1
- Probable cinnamyl alcohol dehydrogenase 9
- UDP-glycosyltransferase 72E1
- Small ribosomal subunit protein uS9x
- Cinnamyl alcohol dehydrogenase 8
- Protein GAMETOPHYTE DEFECTIVE 1
Sequence:
MKTMTQLNIAVVVVVTVLIGMLRSSEAQLQMNFYAKSCPNAEKIISDHIQNHIHNGPSLAAPLIRMHFHDCFVRGCDGSVLINSTSGNAERDAPPNLTLRGFGFVERIKALLEKVCPKTVSCADIIALTARDAVVATGGPSWSVPTGRRDGRISNKTEATNNIPPPTSNFTTLQRLFKNQGLNLKDLVLLSGAHTIGVSHCSSMNTRLYNFSTTVKQDPSLDSQYAANLKANKCKSLNDNSTILEMDPGSSRSFDLSYYRLVLKRRGLFQSDSALTTNSATLKVINDLVNGSEKKFFKAFAKSMEKMGRVKVKTGSAGVIRTRCSVAGS
Protein: BC029127 protein (Q8K2Z5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
FAWHSHLQRHEITHTGEKPYECNQCGKAFAHDSNLHIHKRKHAGEKPYECNQCGKAFPCYNLLQIHKRTHTGEKPYECNQCGKTFAYHSYLQMHERIHTGEKPYECNHCGKAFSQHSSLRVHKRTHTGEKPYECNQCGEAFVYHSHLQIHKTMHTGEKPFQCNQCDKAFVYNNHLLVHKRIHTGEKPYECNHCGKAFSQLSGLHVHKRTHTGEKPYKCNECGKAFARNSHLQRHKRIHTGEKPHECNQCGKAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHKRTHTGEKPYECNQCGKTFAYHSHLQVHGRIHTGEKPYKCNQCGKAFACHRNLRVHKRKHTGEKPYEFNHYSKAFSQHSSLQVHKRTHIGEKSYEL