wanglab/gogpt-training-data huggingface dataset:
Protein: FtsK domain-containing protein (A0A0H3LKM7)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Interaction partners:
Sequence:
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTFKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLVEAITAGVTQIASQHTEQAPPVRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHMIVGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLSGEKQEFPSSEFKVKRRPPGQAFLVSPDGKEVIQAPYIEPPEEVFAAPPSAG
Protein: Acetylcholine receptor subunit alpha (P04756)
Organism: Mus musculus (Mouse)
Function: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P02708}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P02708}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit gamma
- Acetylcholine receptor subunit delta
- Acetylcholine receptor subunit epsilon
- Neuronal acetylcholine receptor subunit alpha-9
- Neuronal acetylcholine receptor subunit alpha-3
- 43 kDa receptor-associated protein of the synapse
- Neuronal acetylcholine receptor subunit alpha-4
- Myogenin
- Neuronal acetylcholine receptor subunit alpha-2
Sequence:
MELSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKRIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLAVFAGRLIELHQQG
Protein: NACHT, LRR and PYD domains-containing protein 4F (NALP-kappa) (Q66X05)
Organism: Mus musculus (Mouse)
Function: Required for cytoplasmic lattice formation, thereby modulates the distribution of organelles during oocyte maturation and zygote development. Required for preimplantation development in female fertility. May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:31575650}. Note=Expressed and colocalizes with NLRP5 at the oocyte subcortex. {ECO:0000269|PubMed:31575650}.
Interaction partners:
Sequence:
MASFISDFGLIWYLRELNKKEFMKFKDFLIQEILELKLKQVSSTKVKKASREDLANLLLKCGENQAWDMTFRILQKINRKDLTERATGAIVGNPNLYRDHLKKKLTHDCPKKFNVRIQDFIKETFIQNDXDAFENLLISKGTERKPHMVFLKGMAGVGKTLMLKNLMLAWSKGLVFQNKFSYAFYFCCQDVKQLKTASLAELISREWPSPSAPIEEILSQPEKLLFIIDSLEGMEWDLTKQESELCDDCMEKQPVSTLLSSLLRRKMLPESSLLLSTTPETFEKMEDRIQCTDVKTATAFDERSMKIYFHRLFQDRKRAQEAFSLVRENKQLFTICQVPLLCWMVATCLKEEIEKGGDPVSLCRRTTSLYTTHIFSLFIPQSAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFGKEALRRNGIFDSDIPTLLDIGMLGKIREFENSYIFLHPSVQEVCAAIFYMLKRHVEHPSQDVKNIETVLFMFLKKVKTQWIFLGCFIFGLLQKSEQEKLGVFFGHRLSKNIHHKLYQCLETLSGNAELQEQIDGMRLFSCLFEMEDEAFLVKAMNCMQQINFVAKNYSDFIVAAYCLKHCSTLKKLSFSTENVLNEGDQSYMEELLICWNNMCSVFVRSKDIQELRIKDTNFNEPAIRVLYESLKYPSFTLNKLVANNVSFGDNHVLFELIQNSSLQYLDLSCSFLSHNEVKLLCDILNQAECNIEKLMIAHCKLSPDDCKIFGSILMSSKSLKVLNLASNNLNQGISSLCKALCHPHCTLEYLVPRSNHCIVNFLLKLSCCGITERGCQDLAEVLKNNQNLKYLHVSYNKLKDTGVMLLCDAIKHPNCHLKDLQLEACEITDASNEELCYAFMQCETLQTLNLMGNAFEVSRMVFFPRKSELMLFIFLHLSRLWITDFDNEFQAFLLSVKKKNHFLTIRGSVEADGEKKGGDSDARTMGELSNEI
Protein: Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7) (Q9WV07)
Organism: Mus musculus (Mouse)
Function: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (By similarity). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}.
Interaction partners:
- Magnesium transporter NIPA4
- Protein-glutamine gamma-glutamyltransferase K
- Omega-hydroxyceramide transacylase
- Glucosylceramide transporter ABCA12
Sequence:
MAVYRLCVTTGSYLKAGTLDNIYATLVGTCGESPKQKLDRVGRDFASGSVQKYKVRCEAELGEILLLRLHKERFAFFCKDPWYCSRICVTAPDGSAVHFPCYQWIDGYCTVELRPGTARTICQDSLPLLLDHRKRELQARQECYRWKIFAPGFPRMVDVSSFQEMESDKKFALTKTVPCAEQDDNSGNRYLPGFPMKIDIPSLLHMEPNIRYSATKTASLIFNALPASFGMKIRGLLDRKGSWKRLDDIRNIFWCHKTFTSEYVTEHWCEDSFFGYQYLNGVNPVMLHCLSSLPSKLPVTNDMVAPLLGPGTCLQTELERGHIFLADYWILAEAPVHCINGLQQYVTAPLCLLWLNPQGVLLPLAIQLSQTPGPESPIFLPTDCELDWLLAKTWVRNSEFLVHENNTHFLCTHLLCEAFSMATLRQLPLCHPVYKLLLPHTRYTLQVNTIARATLLNPDGLVDKVTSIGRQGLIYLMSTGLAHFTYTDFCLPDSIRARGVLTIPNYHYRDDGLKIWAAIERFVSEIVSYYYPSDASVQQDCELQAWVGEIFAQAFLGRESSGFPSRLCTPGELVKYLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGDTTMKSYLDTLPEVNTTCRNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRQSIAAFQNCLAQISKDIRERNQSLALPYAYLDPPLIENSVSI
Protein: Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) (Q6X973)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}.
Interaction partners:
Sequence:
THRLLLLGAGESGKSTIVKQMRILHVNGFNGDEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVQACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVGKVNFHMFDVGGQRDERRKWIQCFNDVTVIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDAAPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Protein: DNA-binding protein inhibitor ID-3 (Helix-loop-helix protein) (Id3 protein) (Inhibitor of DNA binding 3) (Q8QFX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKAISPVRSVRSCYEAVCCISEQSLAISRCKSPSEELSDMNMNDCYSKLKELVPSIPQNKSVSQVEILQHVIDYIFDLQIALENETDTQNTPDIFLSMKNSEMSRNFSKEDGAMCH
Protein: Protein SMALL AUXIN UP-REGULATED RNA 9 (O65648)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Provide a mechanistic link between auxin and plasma membrane H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), and triggers PM H(+)-ATPases activity by promoting phosphorylation of their C-terminal autoinhibitory domain as a result of PP2C-D subfamily of type 2C phosphatases inhibition, thus leading to the acidification of the apoplast and the facilitation of solutes and water uptake to drive cell expansion. Triggers plant growth probably by promoting cell elongation (By similarity). Regulates branch angles and bending (By similarity). Probably involved in light intensity mediated root development.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9FJG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9FJG1}.
Interaction partners:
- Probable protein phosphatase 2C 21
- Probable protein phosphatase 2C 79
- Putative DNA repair protein recA homolog 4
- Auxin-responsive protein IAA11
- Probable protein phosphatase 2C 63
- Probable protein phosphatase 2C 68
- Probable protein phosphatase 2C 64
- Probable protein phosphatase 2C 5
- Probable protein phosphatase 2C 38
- Probable protein phosphatase 2C 46
Sequence:
MAIKKSNKAALSQAASLKQILKRCSSLGKKNQGNCYFNDVPKGHFPVYVGQHRSRYVVPISWLDHHEFQSLLQLAEEEFGFEHEMGLTIPCDEVVFRSLISMFR
Protein: Uncharacterized protein (Q4GYD0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cell division cycle 45
- DNA polymerase
- DNA replication complex GINS protein SLD5
- Uncharacterized protein
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM3
- GINS subunit domain-containing protein
- DNA replication licensing factor MCM5
- GINS subunit domain-containing protein
- DNA polymerase II subunit 2
Sequence:
MEHPHLQVHSPGPIRVSIDGHYALSGGADGVVALHPLRRFPTAQPLWARQCHTGAVTCVRLHTALRLAISCGRDGTVVLHENVISDVNATSNNNSNTNASTAGTDANSGEHTVRVMCRVTGELRTVLFDSERRRVFIAGDSLRCLHMSPSGCVVQTIPMCVPSPVVSLALSPCGGVLAVASASCALGVVSVCSSSSNDSASSHFSRENSQESQERANRLKDLKIVLPNVLTPVAKREDEVAYRLTWCTTGNGALFLLVPRVTEARVLRFEEATTPPYTHRLRHVGNIDSLGLTDLLGVACHPLSVHVISVLLVSGAGTVVGKVDTRKWNIVRIRSQNYTGCADAEVDSTSGDVVVGTLDGRVTYMKREAPKAVGASTKGATEGEGKTNRVSESDCGGAKKKLKTEPSVRDRSRDVTNGDKAGQRNNREVRDGGGRDGSDDGFIVDDDDSGSSGGVKSVSSGSSVMAVEEDFKQVVADLKRTNPTYDDEIDQKERPSRWRREDPRRVIRDVEDGDATGTPRRSVFLDDEAEESSDGNSDDDGREEEDEEGEDDYDGNHVASTVRGHGRKKFNDGGDNDCDSEAVDVGSTSSSTHLPNDAAATHSGAAMGGSPVMDYFFQIGATPPGEEGSCYLAYNSVGYIHCTAEATTIHFHDMSLQAVRVLERGTMLMASLSPVGAAFVIAQEATDMESVDDLVPRLTIYYRTFVSIGLQPDWRLRLHTGEVVRCIATGVRYTAVATSRYLRIFSLSGLQLAVISLFPRIVAMVGTNSKKVMQGYGADFDPLAVCYLEGGGELRLQVLDVGSRSVVVPATTVPVTTTHQLQWMGWSEDGPLHIADTAGVLQMFTQNWGGSWVPVYDPRCMNDQTYNLWIWGVCDESMLVYRSCKDDPPYPAAVASGLPTERVSLFLPLLHSGTERDTVMWDHLIRREVRTDEIKRRSDFYTSNIAKHDMLHDKKIMEFFNKALGDQQTSRAVDLATFLELRDNIEVCAKEANAKGHAQLVQKLLALLEVRVKSRKKRRCSLPLEGSVVSERERDMLLRKMLMKEKSEMNNNNGSGDSTKVHSSLGATSNECGHDNTKGDGTNSSNPTAGSPDRSLNQVEDKPETANSSCATASFPTRRRVTFADAPSSSPSPGRSLRASPGGAGAVSTKTPAVLGPSSASKATNPFSKRPTGGKAPTTASTAATAVQAPPQPKKPINPFNKSVKAATSSVDLSALQSRSLTQSPEKGAPPSTTMLVLGDSQSQDTFETEGSEGRTKDLEMGRDVVGSPQQRLSSNASAVTPLLSPSLTTSAAASGTPKRGDGAGMQSPEAAAHGPGCNKGNVMHPQKGISTETVHPATQKDSTNGLYTAGGLATTTTVTRTQNNSVTTTHFVPKVEPFLSPQNAVSSSLPVTNEVADPFLDVNDGGPVSLDSLLLDVGHDSSATFTPRSASFGAALLKRYREEEEDNSNGSVGFVVETKLSAAAAGNDIDGSGSGGSHDNVGL
Protein: Protein NIM1-INTERACTING 2 (Protein NIMIN-2) (Q9LUA3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:11442055}.
Interaction partners:
- Regulatory protein NPR1
- Protein NIM1-INTERACTING 3
- Protein NIM1-INTERACTING 1
- Regulatory protein NPR3
- At4g01895
- Regulatory protein NPR4
- CAP superfamily protein
Sequence:
MNNSLKKEERVEEDNGKSDGNRGKPSTEVVRTVTEEEVDEFFKILRRVHVATRTVAKVNGGVAEGELPSKKRKRSQNLGLRNSLDCNGVRDGEFDEINRVGLQGLGLDLNCKPEPDSVSLSL
Protein: EF-hand domain-containing protein D2 (Swiprosin-1) (Q9D8Y0)
Organism: Mus musculus (Mouse)
Function: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Subcellular location: Membrane raft {ECO:0000269|PubMed:15749887}. Note=In immature B-cell line WEHI-231.
Interaction partners:
Sequence:
MATDELASKLSRRLQMEGEGGEATEQPGLNGAAAAAAAEAPDETAQALGSADDELSAKLLRRADLNQGIGEPQSPSRRVFNPYTEFKEFSRKQIKDMEKMFKQYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKSMIQEVDEDFDSKLSFREFLLIFRKAAAGELQEDSGLQVLARLSEIDVSTEGVKGAKNFFEAKVQAINVSSRFEEEIKAEQEERKKQAEEVKQRKAAFKELQSTFK
Protein: ATP-dependent DNA helicase II subunit 1 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku70) (High affinity DNA-binding factor subunit 1) (P32807)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
Subcellular location: Nucleus {ECO:0000269|PubMed:9635192}. Chromosome, telomere {ECO:0000269|PubMed:9635192}.
Interaction partners:
- ATP-dependent DNA helicase II subunit 2
- DNA ligase 4
- Telomerase reverse transcriptase
- Cell division control protein 13
- Regulatory protein SIR4
- DNA repair and recombination protein RAD52
- Exodeoxyribonuclease 1
- ATP-dependent helicase SGS1
- Telomere elongation protein EST1
- Serine/threonine-protein kinase CHK1
Sequence:
MRSVTNAFGNSGELNDQVDETGYRKFDIHEGILFCIELSETMFKESSDLEYKSPLLEILESLDELMSQLVITRPGTAIGCYFYYCNREDAKEGIYELFPLRDINATFMKKLNDLLEDLSSGRISLYDYFMFQQTGSEKQVRLSVLFTFMLDTFLEEIPGQKQLSNKRVFLFTDIDKPQEAQDIDERARLRRLTIDLFDNKVNFATFFIGYADKPFDNEFYSDILQLGSHTNENTGLDSEFDGPSTKPIDAKYIKSRILRKKEVKRIMFQCPLILDEKTNFIVGVKGYTMYTHEKAGVRYKLVYEHEDIRQEAYSKRKFLNPITGEDVTGKTVKVYPYGDLDINLSDSQDQIVMEAYTQKDAFLKIIGFRSSSKSIHYFNNIDKSSFIVPDEAKYEGSIRTLASLLKILRKKDKIAILWGKLKSNSHPSLYTLSPSSVKDYNEGFYLYRVPFLDEIRKFPSLLSYDDGSEHKLDYDNMKKVTQSIMGYFNLRDGYNPSDFKNPLLQKHYKVLHDYLLQIETTFDENETPNTKKDRMMREDDSLRKLYYIRNKILESEKSEDPIIQRLNKYVKIWNMFYKKFNDDNISIKEEKKPFDKKPKFNI
Protein: ATP synthase protein MI25 (Q2F9A1)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004304}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004304}.
Interaction partners:
Sequence:
MGLSSTDKKDRRNMLFAAIPSICASSPKKISIYNEEMIVARCFIGFLIFSRKSLGKTFKETLDGRIESIQEELQQFFNPNEVIPGESNEQQRLLRISLRICSAVVESLPTARCAPKCEKTVQALLCRNLNVKSATLLNATSSRRIRLQDDIVTGFHFSVSERFVSGSTFKASTVEQIREAFVPIDLIREGLIVLRKV
Protein: SAM-dependent MTase RsmB/NOP-type domain-containing protein (Q580I8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Calponin-homology
- Calponin-homology
- Replication Factor A 28 kDa subunit, putative
- Uncharacterized protein
- DNA repair protein, putative
- Uncharacterized protein
- Replication protein A subunit
- Crossover junction endonuclease MUS81
Sequence:
MSDDASQNYPSSFTEEFINYCRAHRLPPQLFHDLRELLPRMPRYVRIRPSDAQQRILPCSCDQGSRVPSDVIHELSTAVGGPTGCVYEVEWLPRPYCLALPRDTAVSQLELYRSGVVSAMDAASIAAVVALRPRRGETVWDVCCSPGMKLSFIADAIGEEGSAVGTDINLDRLFAARSVMKKHRANNVCLFVADGTSFALRTAVAVAQAAKLYRGKSNTDGLTALEERRLRYMKKRRAGGAADSSDGTVTRDEDDQVALVFTCDEARKRLVQSGESANQKHYGFDRVLVDAECSHDGSLAHMFLGGGTKRPFAGHDGDADVASQAINNEQRMQRLNLSLPDGNEFANAEVRKVSPLQQLQLQLLTNGYAQLNPGGTLVYCTCSFTYQQNEGIVQEMMHSVNADAETMERYGGEAVLCSPFCYEHEVGLEAQVSPIVILSGTQVGLLKQRLAAAGDPYGVTTGLAREGAEEVGVRFWPHIFSTSFQFISKVWKKPLT
Protein: Malate synthase G (EC 2.3.3.9) (P9WK16)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00641}.
Interaction partners:
Sequence:
MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAAR
Protein: Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) (Q15459)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277}. Nucleus speckle {ECO:0000269|PubMed:21349847}.
Interaction partners:
- Splicing factor 3B subunit 3
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Splicing factor 3B subunit 2
- Probable ATP-dependent RNA helicase DDX46
- Pre-mRNA-processing factor 6
- U4/U6.U5 tri-snRNP-associated protein 1
- Microfibrillar-associated protein 1
- Small nuclear ribonucleoprotein G
- Splicing factor 3B subunit 5
- Splicing factor 3A subunit 2
Sequence:
MPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQQQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKTEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK
Protein: Pre-mRNA-splicing factor CWC23 (Complexed with CEF1 protein 23) (P52868)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor BUD31
- Pre-mRNA-splicing factor SPP382
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor NTR2
- Pre-mRNA-splicing factor 8
Sequence:
MPGHELEDVINQRLNLYDVLELPTPLDVHTIYDDLPQIKRKYRTLALKYHPDKHPDNPSIIHKFHLLSTATNILTNADVRPHYDRWLIEFLRKTNDIERNKLIQKLEESESSTIPTTTPHPDLLQIQRHGELLRKLKHFNLPYGDWKHLNTQDQENASQHPYYDCSTLRIVLDNFLQSNNKSNCLSHLRNQVFITLSANEIYDIYFSERNNYSKDDSIIIYTVFDTPITAQHVFRNWSSGNLIPTVKDISPLIPLHYYSDFNLETELNDDIARLVSNEPILLD
Protein: Calcium uniporter protein (A0A0G2K059)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367035}.
Interaction partners:
Sequence:
MAAAAGRSLLLLLCSRGGGGGAGGCGALTAGCFPGLGVSRQRPHQQHRTAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQKWILRD
Protein: P-granule-associated protein deps-1 (Defective P granules and sterile protein deps-1) (Q9N303)
Organism: Caenorhabditis elegans
Function: Component of P-granules which is required for P-granule formation and integrity in adult germ cells. Promotes the accumulation of glh-1 mRNA and localization of pgl-1 to P-granules. Involved in RNA-mediated gene silencing (RNAi) in the germline. In particular, it is required for piwi-interacting RNA (piRNA) gene silencing and positively regulates the formation of secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Its role in RNAi may also be through positively regulating the expression of the dsRNA-binding protein rde-4. Plays a role in small RNA-directed transgenerational epigenetic inheritance.
Subcellular location: Cytoplasmic granule {ECO:0000269|PubMed:18234720, ECO:0000269|PubMed:32843637}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32843637}. Note=Localizes to P-granules in germ cells at all stages of development (PubMed:18234720). Co-localizes with prg-1 at peri-nuclear P-granules in the proliferative zone and transition zone, at pachytene, in oocytes and in embryos (PubMed:32843637). In the distal loop, a higher proportion of deps-1 than prg-1 dissociates from the perinuclear region (PubMed:32843637). In the adult germline, co-localizes with znfx-1 at P-granules and with pgl-1 at P-granules in the pachytene region (PubMed:32843637). {ECO:0000269|PubMed:18234720, ECO:0000269|PubMed:32843637}.
Interaction partners:
- Guanyl-specific ribonuclease pgl-1
- ATP-dependent RNA helicase glh-1
- Guanyl-specific ribonuclease pgl-3
- ATP-dependent RNA helicase glh-4
- Protein edg-1
- Argonaute protein wago-1
- Argonaute protein hrde-1
- NFX1-type zinc finger-containing protein 1 homolog
- Uncharacterized protein
- ATP-dependent RNA helicase glh-2
Sequence:
MSERQSKYFDYQGIVISSTGQDNQDSETDLVYLIQAHGKAAPKNIMYGVSKCAFVPTNLERNFDNIEEAKNLERRSKIPLKFGEVILWNESDCDHDKRIILHIKREKPIYEASSSRNGLILKVGGVIQPTSTTSFWTPLCTVTMPETEATRAEPDVWLYAWIRFETTMKSGLDPFNMTATFESFDSCDPSDQARVCEAPWNAGSPDSKFGVWRPDPKPADSDDEIDIEPREGWHLPEDKWAEVIKMQLGLYVGERLLICKELSQFDFIIPLQKPFSRGTDKTLIYPAVGEYFHFSAIWSMQHNGFLIYELQPVPLLRQHVTSVNGNLLTRVVPASIRGLFVDKEGTLGLIDDPHHLLSFFEFHPAGYEFLKAMAEVRAVRTSENKSVRYRIVRTSGMSIFENWLRDTQFVVGPVKGIRINEDTVICAKHPNVYFKIPNNLKEGIPIGGGVQFVGKRQAGVDSEIMITECSPCPAFTCKNYSVSGDTRLFQVYLKPNCDHEQLAESDSMGFVDFRELETPCRGKFLAWVRESITVNDCRRAATIMEVCSTAICPPLIAMSANSSRATSARTTPAGSSIGSRSSIQSRASAATSVSSNRFVGPSSRRTPSGTPQSSTSSRV
Protein: WD-repeat protein GhTTG2 (Q8L4X6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MAASSDPNPEGSDEQQKRSEIYTYEAPWHIYAMNWSVRRDKKYRLAIASLLEHYNNRLEIVQLDDSNGEIRSDPNLSFDHPYPPTKTIFIPDKECQKPDLLATSSDFLRIWRISDDHSRVDLKSLLNGNKNSEFCGPLTSFDWNEAEPKRIGTSSIDTTCTIWDIERETVDTQLIAHDKEVYDIAWGGVGVFASVSADGSVRVFDLRDKEHSTIIYESSEPDTPLVRLGWNKQDPRYMATIIMDSAKVVVLDIRFPTLPVVELQRHQASVNAIAWAPHSSCHICTAGDDSQALIWDLSSMSQPVEGGLDPILAYTAGAEIEQLQWSSSQPDWVAIAFSTKLQILRV