wanglab/gogpt-training-data huggingface dataset:
Protein: Cytosolic Fe-S cluster assembly factor NBP35 (Nucleotide-binding protein 35) (P52920)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Fe-S cluster assembly protein DRE2
- NADPH-dependent diflavin oxidoreductase 1
- Cytosolic Fe-S cluster assembly factor CFD1
- Cytosolic Fe-S cluster assembly factor NAR1
- DNA repair/transcription protein MET18/MMS19
- Iron-sulfur clusters transporter ATM1, mitochondrial
- MIP18 family protein YHR122W
- Cysteine desulfurase, mitochondrial
- Cytosolic iron-sulfur protein assembly protein 1
- DNA polymerase delta catalytic subunit
Sequence:
MTEILPHVNDEVLPAEYELNQPEPEHCPGPESDMAGKSDACGGCANKEICESLPKGPDPDIPLITDNLSGIEHKILVLSGKGGVGKSTFAAMLSWALSADEDLQVGAMDLDICGPSLPHMLGCIKETVHESNSGWTPVYVTDNLATMSIQYMLPEDDSAIIWRGSKKNLLIKKFLKDVDWDKLDYLVIDTPPGTSDEHISINKYMRESGIDGALVVTTPQEVALLDVRKEIDFCKKAGINILGLVENMSGFVCPNCKGESQIFKATTGGGEALCKELGIKFLGSVPLDPRIGKSCDMGESFLDNYPDSPASSAVLNVVEALRDAVGDV
Protein: Rab GDP dissociation inhibitor (Q582R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small GTP-binding protein RAB6, putative
- Ras-related protein Rab-7b
- Small GTP-binding protein Rab18
- Ras-related protein Rab-21
- Small GTPase, putative
- Ras-related protein rab-5
- Small GTP-binding protein Rab28, putative
- Small GTP-binding protein Rab7, putative
- ATP synthase regulation protein NCA2
- Intraflagellar transport protein 27 homolog
Sequence:
MEETYDAIVCGTGLTECVLSGLLSVNGYKVLHVDRNSYYGGEAASLNLEQLYKKFGKGTPPEALGRSHLYSVDLIPKVLMCAGELVKILRATVIERYNMEFMLIDNSFVMKNGKISKVPATEAEALVSPLMGFFEKRRGAKLFEFIGAYDPNVPKTHKGHNLRTMTMADLYKEFGIGNDTIDFVGHAVALHTNDDYLQRPAIETVMRCKLYEESFNMYNQSPYVYPLYGNGELPQAFSRLCAVYGGTYMLQTPVTKVNFNEAGVFESIESEGKKAFAKLVVGDPSYFPDRVKVSGKVVRCIAIMNHPIPNLKPECASCQIIIPQKELKRKNDVYILQLGANNKVCPPGYYIAIIGTTVENVADPMMDIQPGLKVIGSTIETFVSVSDLYEPLDDGTASKCFISNSFDPATHFESAAGNILDLFKRIHGKPFDFECMKSTASNEDR
Protein: Always early (Q2PNN0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRVKPGVASKRIENLTKKPSKISVDVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLXGKSFEGIVNGTVMGYDPQDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLSIIMRGDKSSSVISESAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLRILHDYLVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNEKLGRENSSTLETIIADLVTHMVDNIQPSLGRKLNDGVDSVEPLRQQEVQLFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS
Protein: Platelet-derived growth factor subunit A (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) (A5PMP7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor c
- Platelet-derived growth factor d.
- Platelet-derived growth factor beta polypeptide a
- Epidermal growth factor.
- Platelet-derived growth factor subunit B
- Platelet-derived growth factor alpha polypeptide b
- Platelet-derived growth factor receptor, beta polypeptide
- Vascular endothelial growth factor receptor 2
- Fibroblast growth factor receptor 1-A
Sequence:
MRTALIHFLVCCFSLLSAAAEEAPIPRELIERLSNSEIHSISDLQRILEMDFLENEVLEDVKQGHHKEHLYDSRNLKNLHSRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTAANFLIWPPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVRRRPKLREVQVQLEDHLECVCTSRHHSESRIHTADIR
Protein: Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (NimA-related protein kinase 6) (OsNek6) (Q6YY75)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May be involved in plant development processes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21719639}. Note=Localizes in cytoplasmic spots associated with tubulin. {ECO:0000269|PubMed:21719639}.
Interaction partners:
Sequence:
MEQYEVVEQIGRGAYGSAYLVVHKGERKRYVMKKIRLSKQNDKFQRTAYQEMSLMASLSNPYIVEYKDGWVDEGTSACIVTSYCEGGDMAERIKKARGVLFSEERVCRWFTQLLLALDYLHCNRVLHRDLKCSNILLTKDNNIRLADFGLAKLLMEDLASTIVGTPNYMCPEILADIPYGYKSDIWSLGCCMFEILAHRPAFKAADMASLINKINRSSISPMPPIYSSSLKQIVKSMLRKNPEHRPTAGELLRHPYLQPYLAESCSCSPIYLPVKPTKSNLGDKQQSRKPGSGRKRIIKTNGSSEALETAAEQAVDTRDNSTYISDVSTVGTQDACISQVSVDPQARNKAYQNIDDLTLFQQIEENLMTITDRQIDEAIFLKAVRTSSTVDVVPVSGAIQKPNEAPIPKEELTIGVVQEQRKEVKAHTHQGSKPGTGDVPIVTEESSPKSAVKLAHSDSTPAEWDHLNIVQQRADALESLLELCAKLLKQERLEELAGVLRPFGEGAVSSRETAIWLTKSLMTPPKLEGSPKLT
Protein: Protein VP3 [Includes: 2',5'-phosphodiesterase (EC 3.1.4.-); mRNA guanylyltransferase (EC 2.7.7.50); mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56)] (B3F2X4)
Organism: Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]) (RV-A)
Subcellular location: Virion {ECO:0000256|HAMAP-Rule:MF_04128}. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion. {ECO:0000256|HAMAP-Rule:MF_04128}.
Interaction partners:
Sequence:
MKVLALRHGVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYLNYSIKTLEILNKSGIAAVEIQSLEELFTLIRCNFTYDYENNIIYLHDYSYYTNNEIRTDQHWVTKTDIEEYLLPGWKLTYVGYNGSDTRGHYNFSFTCQNAATDDDLIIEYIYSEALDFQNFMLKKIKERMTTSLPIARLSNRVFRDKLFPLLSEKHQRIVNIGPRNESMFTFLNFPSIKQFSNGPYLVKDTIKLKQERWLGKRVSQFDIGQYKNMMNVITTVYYYYNLYQKKPIIYMVGSAPSYWIYDVKQYSDFMFETWDPLDTPYSSVHHKELFFEKDITRLKDDSILYIDIRTDRGNTDWKEWRKIVEAQTISNLKLAYRYLSGGKSKVCCVKMTAMDLELPISAKLLHHPTTEIRSEFYLLLDIWDISNVKRFIPKGVLYSFINNVTTENVFIQPPFKIKPFKNDYIVALYALSNDFNDRTDVINLINNQKQSLITVRINNTFKDEPKVGFKNIYDWTFLPTDFTTTDAIITSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQIRFSESATSYSGYIFRDLSNNNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSIEKADIEGGKYYEHAPIELIYACRSAKEFALLQDDLTVLRYANEIESYINKVYSITYADDPNYFIGIKFRHIPYEYDVKIPHLTFGVLFISDNMIPDVVEIMKIMKKELFEMDITTSYTYMLSDGIYVANVSGVLATYFKMYNLFYKSQITFGQSRMFIPHITLSFSNNKTVRIESTRLKISSIYLRKIKGDTVFDMSE
Protein: Chlorophyll a-b binding protein CP29 (Lhcbm4) (Q93WD2)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. CP29 facilitates the State 1 to State 2 transition, where State I is induced by excess photosystem I (PSI) light and State 2 is induced by excess photosystem II (PSII) light.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:15094049}; Multi-pass membrane protein {ECO:0000269|PubMed:15094049}.
Interaction partners:
Sequence:
MVFKFPTPPGTQKKAGTTATKPAPKATTKKVATSTGTRSGGVGYRKYQGDALWLPNTTRPEWLDGSLPGDRGFDPLGLSKPSEFVVIGVDENDQNAAKNNKGSVEAIVQATPDEVSSENRLAPYSEVFGLARFRECELIHGRWAMLACLGALVAEATTGVSWVEAGKVELDGASYAGLSLPFSITQLIWIEVILVGGAEFYRNSETNPEKRCYPGGVFDPLKLASEDEERAFRLKTAEIKHARLAMVSFFGYGVQALSTGEGALGSLAKFADGLNNGKGL
Protein: Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) (O08721)
Organism: Rattus norvegicus (Rat)
Function: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12598531, ECO:0000269|PubMed:19755150, ECO:0000269|PubMed:9126742}; Single-pass type I membrane protein {ECO:0000269|PubMed:12598531, ECO:0000269|PubMed:9126742, ECO:0000305}. Membrane raft {ECO:0000269|PubMed:18582460}. Cell projection, neuron projection {ECO:0000269|PubMed:19755150}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones (PubMed:14672991). {ECO:0000269|PubMed:14672991}.
Interaction partners:
- Netrin-1
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
- Netrin receptor DCC
- Proto-oncogene tyrosine-protein kinase Src
- Netrin 4.
- Focal adhesion kinase 1
- Tyrosine-protein phosphatase non-receptor type 11
- Leucine-rich repeat transmembrane protein FLRT1
Sequence:
MAVRPGLWPVLLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDSSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSTSAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTACATLCPVDGSWSSWSKWSACGLDCTHWRSRECSDPAPRNGGEECRGADLDTRNCTSDLCLHTASCPEDVALYIGLVAVAVCLFLLLLALGLIYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCSRQDGPSPKFQLSNGHLLSPLGSGRHTLHHSSPTSEAEDFVSRLSTQNYFRSLPRGTSNMAYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPVVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEESPSHLYYCQLEAGACYVFTEQLGRFALVGEALSVAATKRLRLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQQYLHCTFTLERINASTSDLACKVWVWQVEGDGQSFNINFNITKDTRFAELLALESEGGVPALVGPSAFKIPFLIRQKIIASLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLGQLAAAVAGLGQPDAGLFTVSEAEC
Protein: Wiskott-Aldrich syndrome protein family member (WASP family protein member) (Q9VE13)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU367034}.
Interaction partners:
- Cytoplasmic FMR1-interacting protein
- FI14118p
- Abelson interacting protein, isoform D
- Membrane-associated protein Hem
- Disks large 1 tumor suppressor protein
- Wiskott-Aldrich syndrome protein family member
- Actin-related protein 2
- Protein lap4
Sequence:
MPFVQRVVQPVNVAQATAASLGHASGRFHCTPGKCRNNNCINKQSPDVEVPNGHGSPTSLTRVLVHQAPEDQPVPPAPAPMKKLKHHVEFLSTSPTRHQSQSLPNSRHPSQQRPALGRIASAPQSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCAYDPKTVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKELPVATGATATALASLAHSQSLIPSRSISFNGEVLSSDHEVLQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGILTPALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPNDINKDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGIDQKEIQDAANGNGESKNASNATSPVAPAQQAETTSSDAKKSKKFGRSKSSDILKKESAALPYDKGKSTLTRLNSLKQWGRNRFKFMHRTGELGDQLDTSGCSSQNSSAEKADSHHGSPAGDNSKRDIDDECVVHHLVAQKSESRFSHERKPSYSSSEKSISVSSSGQLRGRLQLSSGPMAAAHVKMRETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSESGRASIGSEITMQPKSSASSTSLNVSSFQPGGAGSGPPSSMLSRRRFLNTSASSSVTSEGTATPELQAEAGAYPGHLDDETSSAYSCDTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTSLHTSSYSFGSQSNQTVLNAESEYELFGRGSTSTTTSSAGTVCTALMSGAASGPDVPERSSSLGKHSGQSRSQSTSASSSTLERSYSSSTIGSTLERTGTIKRNVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLEGVERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQTNDPNRTLTSLTIDVEHGEQDEDEAEQKTPTNSKDHNLNELKQTPTKALSGMFEKLRVKLVPGKSSPAKNQMQPKPANSSAVNDDELYDLAGEYVTIADISNNNNNNKNIGRRNTGMGIYYSNDIVSKRVEPSTSAVSEYVSLNELPQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATSQPPPLPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHTTFAPGPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRPIVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYETIAAPVANLMMPSPSGKSNSSTGSTATSSSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTLQNRRSQPRPQPAGNVTCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFLTSTPTRSGEGERDSENTQLPPMKQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKPAQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFANRRMLRQGQFGSPSKTFAPKMRGPVNMVAAAAAPPRTDIMSTTIPEANSEEDHSNTSGGSRASSEAGETVPSSFDLKRNFFLQTEENNFMRGELKPSFARSNGAAGGGSTEGVNKYVAAPVANPPLPSFETAL
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I5ZWQ4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPVLERYFHSAELGRRWTAPEAVLPSSLGSRPGCQQGPLPWDLPEMIRMVKLVWKSKSELQATKPRGILENEDAFHGFPGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENIQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSESMLNHLAHNKAQWKSLLSNQHRRRGSGQDPAGTAPETLEQTEGATP
Protein: Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Beta-mannanase) (Endo-beta-1,4-mannanase) (Man5A) (ManA) (Q8WPJ2)
Organism: Mytilus edulis (Blue mussel)
Function: Hydrolyzes 1,4-beta linked polysaccharide backbones of mannans. Hydrolyzes mannohexaose (M6) preferentially to mannotriose (M4) and less preferentially to mannotetraose (M3), mannopentaose (M5), and mannobiose (M2); hydrolyzes M5 preferentially to M2, and M3, and less preferentially to mannotetraose M4; hydrolyzes M4 preferentially to M3, and less preferentially to mannose (M1), plus very little M2. Does not hydrolyze mannobiose or mannotriose. Does not hydrolyze xlyan, starch, cellulose or galactose.
Interaction partners:
Sequence:
MLLTALAVLFASTGCQARLSVSGTNLNYNGHHIFLSGANQAWVNYARDFGHNQYSKGKSTFESTLSDIQSHGGNSVRVWLHIEGESTPEFDNNGYVTGIDNTLISDMRAYLHAAQRHNILIFFTLWNGAVKQSTHYRLNGLMVDTRKLQSYIDHALKPMANALKNEKALGGWDIMNEPEGEIKPGESSSEPCFDTRHLSGSGAGWAGHLYSAQEIGRFVNWQAAAIKEVDPGAMVTVGSWNMKADTDAMGFHNLYSDHCLVKAGGKQSGTLSFYQVHTYDWQNHFGNESPFKHSFSNFRLKKPMVIGEFNQEHGAGMSSESMFEWAYTKGYSGAWTWSRTDVSWNNQLRGIQHLKSRTDHGQVQFGL
Protein: Cystatin-9 (Testatin) (Q9Z0H6)
Organism: Mus musculus (Mouse)
Function: May be involved in testis development. May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MSCPLRKKALPLTMLLLLLSFHVLITPVSKANKETNRSVHFIPTVEFAVNTFNQESQDEYAYRMEHIMSSWREKVNFPTVYSMRLQLRRTICKKFEESLDICPFQESHGLNNTFTCLFTVGTYPWITKFKLFRSVCS
Protein: Lipoprotein-releasing system transmembrane protein LolC (P0ADC3)
Organism: Escherichia coli (strain K12)
Function: Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Lipoprotein-releasing system ATP-binding protein LolD
- Outer-membrane lipoprotein carrier protein
- Lipoprotein-releasing system transmembrane protein LolE
- Outer-membrane lipoprotein LolB
- Major outer membrane lipoprotein Lpp
- Macrolide export ATP-binding/permease protein MacB
- Outer membrane lipoprotein RcsF
- Apolipoprotein N-acyltransferase
- Outer membrane protein assembly factor BamA
- Putrescine-binding periplasmic protein PotF
Sequence:
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQLPETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKLPEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
Protein: Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Q8BHC0)
Organism: Mus musculus (Mouse)
Function: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:10187853}; Single-pass type I membrane protein {ECO:0000269|PubMed:10187853}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Interaction partners:
- Vascular endothelial growth factor C
- Stabilin-2
- Vascular endothelial growth factor receptor 3
- Basigin
- Hyaluronan mediated motility receptor
- Podoplanin
- Platelet endothelial cell adhesion molecule
- Endomucin
- Vascular endothelial growth factor D
- Integrin alpha-9
Sequence:
MLQHTSLVLLLASIWTTRHPVQGADLVQDLSISTCRIMGVALVGRNKNPQMNFTEANEACKMLGLTLASRDQVESAQKSGFETCSYGWVGEQFSVIPRIFSNPRCGKNGKGVLIWNAPSSQKFKAYCHNSSDTWVNSCIPEIVTTFYPVLDTQTPATEFSVSSSAYLASSPDSTTPVSATTRAPPLTSMARKTKKICITEVYTEPITMATETEAFVASGAAFKNEAAGFGGVPTALLVLALLFFGAAAVLAVCYVKRYVKAFPFTTKNQQKEMIETKVVKEEKADDVNANEESKKTIKNPEEAKSPPKTTVRCLEAEV
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) (Q99LC3)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:38575788}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 subunit C2
Sequence:
MALRLLRLVPASAPARGLAAGAQRVGRIHTSVHCKLRYGLLAAILGDKTTKKLHEYSRVITVDGNICSGKNKLAKEIAQQLGMKHYPEAGIQYSSTTTGDGRPLDIEFSGSCSLEKFYDDPKSNDGNSYRLQSWLYASRLLQYADALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGYIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVPEVQSRIQKKGDPHEMKVTSAYLQDIENAYKKTFLPKMSEMCEVLVYDSWEAEDPTKVVEDIEYLKYNKGPWLKQDDWTFHYLRMLVQDKTEVLNYTTIPVYLPEITIGAHQGSRIYNSFRELPGRKYAPGYNAEVGDKWIWLK
Protein: Thioredoxin domain-containing protein (Q581Q5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRLTRPFLFITKIAKISRPPASGYEIAELPNEKVFTDFLDHHKTRCVVAILHTGSLHRRVGDGAETSIAEDPLTRSFISSINAVNLGNPNEVKLALVPGPRAKKMVNEYGVLTFPTVLIFLDGKCVERVVGARVRETAIKSLFTLRNAGRNIFSRE
Protein: U3 small nucleolar RNA-associated protein 14 (Q388G9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Nrap protein domain-containing protein
- DDB1- and CUL4-associated factor 13
- Nop14-like protein
- CCAAT-binding factor domain-containing protein
- U3 small nucleolar ribonucleoprotein protein MPP10, putative
- rRNA biogenesis protein, putative
- U3 snoRNA-associated protein UTP11, putative
- Nucleolar RNA binding protein, putative
- RNA helicase
- Small-subunit processome Utp21 domain-containing protein
Sequence:
MVLRRDGNGGGKISKKPAARATGKMKLGRKPRRERDGDGVQRSGVLNLNNPLIPPEFDEDIDDDLAFNSDDEEMYGHFFTKKRTSEALAPPKARSKQNGKKPSGKRCEGEDDMDGEDNALLLQQLRALGEIDGPEDLDFHEKDDDDDDDCIDIADMLDAAQGAEDSNRGETAATRRKKKKKRVDEDGITKKRRRSGVTEEDESIYGPASGVTDSKFGSAMQEMIAAAPKTAAQSRLQRSLANKNNLISVDVDDYTKERAMREKVREVVSQDLEKYKSFLRSYHESKHIQLPMRMPESNPVPSTLGAIVAAAEANLVVDKHEGATTSATSIATDGMTGNATRTSAFRLAGKVNSLLTKAGISKAQLVSEQRGDGIVPFDTNDNDDGVEDTGDLCRRRGRESDAPTTSYMAKLKAMLSYENARRRRVNRIKSKTYRRILRHEKERERERREKAFELLHPEKARAKLAERLMKARVEERITQKHKNTSKWVRHAKRFAQFDEATKDAINEQHMLHDRLMRKMEEDADADAFLNAANEDGGGSEASSEEERVVDRIIADATEKLSGQEGAHGTDSSKKKLTSLLWRGVDDDVEESQVVAAANMTPTEKARAELRGMKFMQQAKEREEKRYEEVLDQIQEDIRRKACGEAVDSDDEPSDFPEDVEDLDAAEPRRVGAPRSLPAKSNASLGRLTFQKEGKEDGGKTTVKVMENIQLKRRRGIDAREGQQKETSQNNVGESSEGGDEEGPMRESGSDDEAVIENTRPAPIVKGKVDRTKPKGEFAGLRKAKTVPPPALSIDTPTPSTAGKRSISTRTTILPKVTKRPRDQSSSFGESERKGTTASNPTNKMGVAQQENSREEGDDEEALLKQQEYLIARAFAQDDVDADFLAEKTAQVTNIMKPVDKNATLPGWGEWGGSDPRLNIKHQAKLHEMELQREIQKTTLLKSRADAALDHVIINHDGVELVPDRMLLHMIPRPFSNPTEFARSMRHPYGPEWNSAISFKEANQPRVEVRQGHVVAPLDLSLRGKKVAKTKRRKGEITTRV
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (A0A0R4IQS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTVEQNVLQQHSQKHQQTLLNQLREVTGTTDVQLLQQALQVSNGDLVEAVAFLTEKNAKVPQQDEATYYQTAQITNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLEESNRAFRETGITDEEQAISRVLEASIAENKASLKRTHTEVWSDSPNPHERKRMENCPVGLKNVGNTCWFSAVIQSLFNLLEFQRLVLHYSPPARMQDLPRNQKEHRNLPFMQELRHLFSLLVGSKRKYVDPSGAVEILKDAFKSSESQQQDVSEFTHKLLDWLEDAFQIKAEEDREGEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSAENSAKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPSMLYMDRYMDRNREITRIKREEIRRLKEHLTVLQQRLERYLSYGSGPKRFPLADVLQYAMEFASSKPVCTSPVEDIDTTAPPGGTIAQLPPPASAGEQPDACVSAEGSGSGLQASQQQQQRVSIHKPFTQSRVPPDLPMHPAPRHITEEELRVLESCLHRWRSEVENDTRDLQASISRIHRTIELMYSDKSMMQVPYRLHAVLVHEGQANAGHYWAYIYDRHHQRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKKPFLIQEEFDKETGQMLSGLDKLPPDLKVFVEADNKLFEREMEEWDALQARKLQQEKLALAAAAAAAAAASVAVQPMSTEPCSPDNTAPQHDPEYMEQQSPSGDSKHLQEDTERAISKAAAEHDEKSPEALLNTSQSSHPDSKLTSDPCPPPDPEQDDPTCPPPGPQRVVEVAIPNVGTFVIQSKEGGYDDEAMMTPNMQGIIMAIGKSRSVYDKCGPEAAFFKAMKVEYTRLLRLAQEDTPPERDYRLQHVIVFFIHNEAPKKIVERTLLMQFADRNLGFDERCKSIMKVARAKLELIKPDEVNLEEYEMWHQDYRIFRETSVFLLIGLELFMKKSFVEALMYLIYAYQYNKELLAKGPYRGHDEELIAHYRRECLLKLNEYAAALFETGEEAKVNTGLSIMNDLVVPCLPLLLVDEMEEKDMVAVEDMRNRWCSYLGQEMEPNLQEKLTDFLPKLLDCSTEIKSFHEPPKLPSYSTLELFERFGRVMTSLTMGRTPADGR
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (Q1JHQ6)
Organism: Streptococcus pyogenes serotype M2 (strain MGAS10270)
Function: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00318}. Secreted {ECO:0000255|HAMAP-Rule:MF_00318}. Cell surface {ECO:0000255|HAMAP-Rule:MF_00318}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. {ECO:0000255|HAMAP-Rule:MF_00318}.
Interaction partners:
Sequence:
MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIKENAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK