wanglab/gogpt-training-data huggingface dataset:
Protein: Thyroid hormone receptor alpha-B (TRalphaB) (Nuclear receptor subfamily 1 group A member 1-B) (P18115)
Organism: Xenopus laevis (African clawed frog)
Function: High affinity receptor for triiodothyronine (T3).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MDQNLSGLDCLSEPDEKRWPDGKRKRKNSQCMGKSGMSGDSLVSLPPAGYIPSYLDKDEPCVVCSDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDGCCIIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEENRVRRRKEEMIKTLQQRPEPSSEEWELIRIVTEAHRSTNAQGSHWKQRRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELTCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGRSLAAFNLDDTEVALLQAVLLMSSDRTGLICTDKIEKCQETYLLAFEHYINHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV
Protein: Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) (O08688)
Organism: Mus musculus (Mouse)
Function: Calcium-regulated non-lysosomal thiol-protease.
Interaction partners:
- Calpain small subunit 1
- Calpain small subunit 2
- Calpastatin
Sequence:
MFSCAKAYEDQNYSALKRACLRKKVLFEDPLFPATDDSLYYKGTPGPTVRWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVIVDDRLPTVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRNQLFERVLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDMCRYFTDIIKCRLINTSYLSIHKTWEEARLHGAWTRHEDPQQNRSGGCINHKDTFFQNPQYVFEVKKPEDEVLISIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVAQVHVLGAAGLKDSPTGANSYVIIKCEGEKVRSAVQRGTSTPEYNVKGIFYRKKLAQPITVQVWNHRVLKDEFLGQVHLKTAPDDLQDLHTLHLQDRSSRQPSDLPGIVAVRVLCSASLTAV
Protein: Gamma-tubulin ring complex subunit Dgrip71 (Q86LC4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHVISTSKKTVLSDFADLETKSEYVHQNAEPTDFQFNGQRRVFVEVDKMAGLAVMRIKEKDGKTPEIQRVRKLTIDNAFCVACAKQSLEEIAVGQSGCVKLYNFRTAQLIHRFPADPQRSTVLYMDYNNTDEYIAAVRDGGDISILGTKTKQKTNTFTIDGDSTLVRFHPSKRFHLSIASYKGAVTVYDVQGMRKIFHASEAHSAPCRDISMCTSQPALLVSVGYDCKINIFDIRRNRAQASTDRLTYSHPLSTVALSECGTYLCAGNLKGELIAYDMRSTKAPLAVRSVHDAAVTRVAFVPVPSGDNQQNGSLNSSENATGLATEAPRVERAPSDELRKSIAANLLSTQNQLTSLGYGVSTPTIVRRDSFCEFLDAQGPRAVDRMSTRLGASYRDSFDWETLNRKPQPYETANRQSLCPPVASGPSSVDNSVNSSTTESLQQTLSGPLKDRSNISGDGKLMKIAETDELCEEQSANISVASSTGGGSDKENPPPVDAEMKRRLRLLSASRNSTPHHANITPQSSNPLLKPQQLLAKSSSGLSAQMDADWRKEFSELRDFVDQRCEKVERELEYVTFSNQRLLANKVTNYMDQQVENTREIRDALALLLQGDSFMREFSRLQNENEMLKAKLKFYQEQEQTESCGE
Protein: (+)-delta-cadinene synthase (EC 4.2.3.13) (Q9LKN1)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
QVSQMPSSSPLSSNKDEMRPKADFQPSIWGDFFLNCPDKNIDAETQKRHQQLKEEVRKMIVAPMANSTQKLAFIDSVQRLGVSYHFTKEIEDELENIYHNNNDAENDLYTTSLRFRLLREHGFNVSCDVFNKFKDEQGNFKSSVTSDVRGLLELYQASYLRVHGEDILDEAISFTSNHLSLAVASLDHPLSEEVSHALKQSIRRGLPRVEARHYLSVYQDIESHNKVLLEFAKIDFNMVQLLHRKELSEISRWWKDLDFQRKLPYARDRVVEGYFWISGVYFEPQYSLGRKMLTKVIAMASIVDDTYDSYATYEELIPYTNAIERWDIKCIDELPEYMKPSYKALLDVYEEMEQLVAEHGRQYRVEYAKNAMIRLAQSYLVEARWTLQNYKPSFEEFKANALPTCGYAMLAITSFVGMGDIVTPETFKWAANDPKIIQASTIICRFMDDVAEHKFKHRREDDCSAIECYMEEYGVTAQEAYDVFNKHVESAWKDVNQEFLKPTEMPTEVLNRSLNLARVMDVLYREGDGYTYVGKAAKGGITSLLIEPIAL
Protein: Uncharacterized protein MRP8 (P35719)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Sphingolipid long chain base-responsive protein LSP1
- Sphingolipid long chain base-responsive protein PIL1
Sequence:
MSNEIELLQKQVSELQDLVKKQSLIISKTGERVLELQLDKQKHDVTDFDSKFSKSISKKSGSATQFDATDFATNEDLVELVKELQGELNFIEERSIRRLVNSLKKDDDDVIAPLPNADGDIPAISDGVFPKSLKEFKDIPDLKLVRLAKFYERLPPTLKEQEDFENFLEGKVEAFHINETTDEEISKELEKFSKDELDDAFNDVARYLGLSLRRGTEIW
Protein: G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2 homolog) (EBI2) (EBV-induced G-protein coupled receptor 2 homolog) (Q3U6B2)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5. Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand. Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand. Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels. Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages. Promotes osteoclast precursor migration to bone surfaces. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P32249}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
Protein: NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 5) (NADH-plastoquinone oxidoreductase subunit 5) (Q6ENB0)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- NAD
- NAD
- NAD
- NAD
- NAD
- Uncharacterized protein
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Uncharacterized protein
- NAD
Sequence:
MEHTYQYAWVIPLLPLPVIMSMGFGLFLVPTATKNLRRIWAFPSVLLLSIAMVFSVHLSIQQINGSSIYQYLWSWTVNNDFSLEFGYLIDPLTSIMLILITTVGILVLIYSDDYMSHDEGYLRFFVYISFFNTSMLGLVTSSNLIQIYFFWELVGMCSYLLIGFWFTRPIAASACQKAFVTNRVGDFGLLLGILGFFWITGSLEFRDLFKIANNWIPNNEINSLLTILCAFLLFLGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLIARLLPLFISLPLIMSFISLIGTLTLFLGATLALAQRDIKRSLAYSTMSQLGYMMLALGIGSYQAALFHLITHAYSKALLFLGSGSVIHSMEPLVGYSPDKSQNMVLMGGLRKYIPITRTCFLWGTLSLCGIPPLACFWSKDEILSNSWLYSPFFGIIASFTAGLTAFYMFRIYLLTFDGYLRVHFQNYSSTKEDSLYSISLWGKRISKGVNRDFVLSTAKSGVSFFSQNLSKIHVNTGNRIGSFSTSLGTKNTFVYPHEPGNTMLFPLLILLLCTLFIGSIGIHFDNEIGELTILSKWLTPSINFFQESSNSSINSYEFITNAISSVSLAIFGLFIAYMFYGSAYSFFQNLDLINSFVKGGPKKYFFHQLKKKIYSWSYNRGYIDIFYTRTFTLGIRGLTELTQFFDKGVIDGITNGVGLASFCIGEEIKYVGGGRISSYLFFFLCYVSVFLFFFLS
Protein: Uncharacterized protein ycf72 (P0C309)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS9
- 40S ribosomal protein S30
- 40S ribosomal protein S23
- 40S ribosomal protein S15
- 40S ribosomal protein S23
- 40S ribosomal protein S15
- 40S ribosomal protein S6
- 60S ribosomal protein L21
- 40S ribosomal protein S6
- Plectin/eS10 N-terminal domain-containing protein
Sequence:
MGAFPSPPPWGWSTGFITTPLTTGRLPSQHLDPALPKLFWFTPTLPTCPTVAKQFWDTKRTSPDGNLKVADLPSFAISFATAPAALANCPPLPRVISMLCMAVPKGISVEVDSSFLSKNPFPNCTSFFQSIRLSRCI
Protein: Testis-specific basic protein Y 2 (Basic charge, Y-linked 2) (Variably charged protein Y 2) (O14599)
Organism: Homo sapiens (Human)
Interaction partners:
- Testis-specific chromodomain protein Y 1
- Testis-specific chromodomain protein Y 2
- Testis-specific basic protein Y 1
- Deleted in azoospermia protein 1
- PTPN13-like protein, Y-linked
- Deleted in azoospermia protein 2
- Ubiquitin-protein ligase E3A
- RNA-binding motif protein, Y chromosome, family 1 member A1
- Deleted in azoospermia 4.
- Ubiquitin carboxyl-terminal hydrolase 9Y
Sequence:
MMTLVPRARTRAGQDHYSHPCPRFSQVLLTEGIMTYCLTKNLSDVNILHRLLKNGNVRNTLLQSKVGLLTYYVKLYPGEVTLLTRPSIQMRLCCITGSVSRPRSQK
Protein: Palmitoyltransferase (EC 2.3.1.225) (A0A0B4LF00)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGNDDHRRRKTPCGFCMAVFKWIPVLFITAVIAWSYYAYVVELCIRNSENRIGMIFMLLFYHLFLTLFMWSYWRTIMTSVGRIPDQWRIPDEEVSRLFRADSPDTQKRILNNFARDLPVTNRTMNGSVRFCEKCKIIKPDRAHHCSVCSCCVLKMDHHCPWVNNCVNFYNYKYFVLFLGYALVYCLYVAFTSLHDFVEFWKGQLNASGMGRFHILFLFFIAIMFAISLVSLFGYHIYLVLVNRTTLESFRAPIFRVGGPDKNGYNLGRYANFCEVFGDDWQYWFLPVFSSRGDGYSYPTSSDQSRVSTSSPTQRYDAMGDTTTSRLDGNPTDKLIGASPLDTTNHHHNQSPHQVRSTSVLPTQLLQIQPPSTCRDELNERQQKLANGQSLDCSTPAAMSSPDERGVNGAAVYIEMIGDHPLTSADPAKGFPRPPNGDLPV
Protein: Peptidase S1 domain-containing protein (Q9D7P8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLLLSLTLSLVLLGSSWGCGVPAITPALSYNQRIVNGENAVPGSWPWQVSLQDNTGFHFCGGSLISPNWVVTAAHCQVTPGRHFVVLGEYDRSSNAEPVQVLSIARAITHPNWNANTMNNDLTLLKLASPARYTAQVSPVCLASTNEALPSGLTCVTTGWGRISGVGNVTPARLQQVVLPLVTVNQCRQYWGARITDAMICAGGSGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNIQAPAMYTRVSKFSTWINQVMCYN
Protein: Nucleolar GTP-binding protein 2 (Q5T0F3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU364023}.
Interaction partners:
Sequence:
MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHKRKKFRQKQ
Protein: sn-glycerol-3-phosphate transport system permease protein UgpE (P10906)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Can also transport glycerophosphoryl diesters, which are hydrolyzed to G3P and alcohol during transport. The G3P moiety can be detected in the cytoplasm whereas the corresponding alcohol is usually found in the culture medium. It was proposed by Yang et al that the complex could also transport glycerol-2-phosphate (G2P) in vivo, but it was shown later by Wuttge et al that UgpB does not bind G2P, questioning this transport activity. G2P might be converted in the periplasm to G3P before its transport.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- sn-glycerol-3-phosphate import ATP-binding protein UgpC
- sn-glycerol-3-phosphate transport system permease protein UgpA
- sn-glycerol-3-phosphate-binding periplasmic protein UgpB
- Maltose/maltodextrin import ATP-binding protein MalK
- Maltose/maltodextrin transport system permease protein MalF
- Inner membrane ABC transporter permease protein YcjO
- Glycerophosphodiester phosphodiesterase, cytoplasmic
- Maltose/maltodextrin transport system permease protein MalG
- Putrescine transport system permease protein PotH
- Spermidine/putrescine import ATP-binding protein PotA
Sequence:
MIENRPWLTIFSHTMLILGIAVILFPLYVAFVAATLDKQAVYAAPMTLIPGTHLLENIHNIWVNGVGTNSAPFWRMLLNSFVMAFSITLGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLQMLDSYAGLTLPLMASATATFLFRQFFMTLPDELVEAARIDGASPMRFFCDIVFPLSKTNLAALFVITFIYGWNQYLWPLLIITDVDLGTTVAGIKGMIATGEGTTEWNSVMVAMLLTLIPPVVIVLVMQRAFVRGLVDSEK
Protein: Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) (Q8R464)
Organism: Mus musculus (Mouse)
Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Cell adhesion molecule 3
- Band 4.1-like protein 2
Sequence:
MGRARRFQWPLLLLWAAAAGPGTGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGGDGHKRKEEFFI
Protein: Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like) (A3KFF6)
Organism: Bos taurus (Bovine)
Function: May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Mitochondrial-processing peptidase subunit beta
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Uncharacterized protein.
- Cytochrome b-c1 complex subunit 7
- Uncharacterized protein.
- Cytochrome b-c1 complex subunit 8
Sequence:
MAVNQSHTESRRGALIPSGESVLKQCEDVDLCFLQKPVESYLFNGTKKGTLFLTSYRVVFVTSHLVNDPMLSFMMPFGLMSDCTIEQPIFAPNYIKGTIQAAPGGGWEGQAVFKLSFRKGGAIEFAQLMVKAASAAARGIPLGSVNYWFDTSGLYIITVPGAAVCSSQTPCPAYPIVIYGPPPPGYTVQPGEYGTPPEGYGAQPGGYGAPPMGYGAPPVGYGVPPGGYGVPPGGYGVPPGGYGAPPGGYGVPPGGYGAPPGGYGAPPAGYGAPPAGNEALPPAYEAPSAGNTAASHRSMTAQQETSLPTTSSS
Protein: Gametogenetin-binding protein 2 (Dioxin-inducible factor 3) (DIF-3) (Protein ZNF403) (Q5SV77)
Organism: Mus musculus (Mouse)
Function: May be involved in spermatogenesis.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:15642376}. Note=Associated with vesicular structures.
Interaction partners:
- Gametogenetin-binding protein 1
- Glucosaminyl-phosphatidylinositol-acyltransferase PIGW
- Ornithine decarboxylase antizyme 3
- CCR4-NOT transcription complex subunit 11
- Dehydrogenase/reductase SDR family member 11
- Gametogenetin
Sequence:
MARLVAVCRDGEEEFPFERRQIPLYIDDTLTMVMEFPDNVLNLDGHQNNGAQLKQFIQRHSMLKQQDLSIAMVVTSREVLSALSQLVPCVGCRRSVERLFSQLVESGNPALEPLTVGPKGVLSLTRSCMTDAKKLYTLFYVHGSKLNDMIDAIPKSKKNKRCQLHSLDTHKPKPLGGCWMDVWELMSQECRDEVVLIDSSCLLETLETYLRKHRFCTDCKNKVLRAYNILIGELDCSKEKGYCAALYEGLRCCPHERHIHVCCETDFIAHLLGRAEPEFAGGRRERHAKTIDIAQEEVLTCLGIHLYERLHRIWQKLRAEEQTWQMLFYLGVDALRKSFEMTVEKVQGISRLEQLCEEFSEEERVRELKQEKKRQKRKNRRKNKCVCDTPASLHTADEKAVSREKETDFIENSCNACGSAEDGETCVEVMVTSENTSCTCPSSGNLLGSPKIKKGMSPHCNGSDCGYSSSMEGSETGSREGSDVACTEGICNHDEHGEDSCVHHCEDKEDDGDSCVECWANSEENNIKGKNKKKKKKSKMLKCDEHIQKLGSCITDPGNRETSGNTMHTVFHRDKTKDAHPESCCSTEKGGQPLPWFEHRKSVPQFTEPTEMSFGPDSGKGAKSLVELLDESECTSDEEIFISQDEIQSFMANNQSFYSNREQYRQHLKEKFNKYCRLNDHKRPVCSGWLTTAGAN
Protein: Poly(A)-specific ribonuclease PNLDC1 (EC 3.1.13.4) (PARN-like domain-containing protein 1) (Poly(A)-specific ribonuclease domain-containing protein 1) (HsPNLDC1) (Q8NA58)
Organism: Homo sapiens (Human)
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27515512}; Single-pass membrane protein {ECO:0000305}. Note=Localizes mainly in the endoplasmic reticulum (PubMed:27515512). {ECO:0000269|PubMed:27515512}.
Interaction partners:
- Poly
- Poly
- Symplekin
- Tudor and KH domain-containing protein
- Mitochondrial cardiolipin hydrolase
- Neuroguidin
Sequence:
MFCTRGLLFFAFLAGLDIEFTGLRSNLSGPQQISLFDLPSEWYLKTRQSVQQFTVCQIGLSVFSAIEGEANKYIAHSCNFYLFPTTFGILDSEFSFQASSVQFLNQYGFNYNKFLKNGIPYMNEEQEKKIRHDILTGNWRVRSSPDKDQIKVVIDEVTRWLELAKEGDWMTLPGITGFQAFEVQLVLRQALPNIWTVLKDEGVVVKKVSKQHRWYLQNTSCDRESCWKENILLSARGFSVFFQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKQNIHSLFPVLIDTKSVTKDIWKEMNFPRVSNLSEVYEVLNSDLNPTKNSGPEIVHASRCEKYVETKCPHEAAYDAFLCGSVLLKVAHLLLQKIYHIDPVPESSFPQYLDVLAPYVNQVNLIRAGVPKINFSGPDYPSIRPPILILSVKRWPGVSEQQVYHKFQNLCKFDVRRLTRSQFLLLTNKFKDARNILKEYRDHPTLCISLYRYWRHSPNVNCLLQVCGIVTAWALLAFILGRSGT
Protein: Cytosolic calcium-binding protein 2 (Cytosolic Ca(2+)-binding protein 2) (O65370)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17145720}.
Interaction partners:
- AT3g13990/MDC16_11)
- Glycoside hydrolase family 28 protein
- Pectin lyase-like superfamily protein
- Pectin lyase-like superfamily protein
- Pollen Ole e 1 allergen and extensin family protein
- Spc97 / Spc98 family of spindle pole body
- Terpenoid synthase 8
Sequence:
MATVEVEQVTPVAVENVEVPTKTVEETVVETEVTQQPEESVPAVTEQKSEAPIVETNEEVVVEEAEKKDEETEKKTEEKDEKTEVITETPVVEEEEKKAEEVTETPAVVEEEKKTEVVEEKQTEVAAAEEVAVEKAEE
Protein: Flavin-dependent halogenase armH5 (EC 1.14.19.-) (A0A0U3C228)
Organism: Armillaria mellea (Honey mushroom) (Agaricus melleus)
Function: Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols. The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product. The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules.
Interaction partners:
Sequence:
MPSEYVPEATTVLVIGGGPAGSYASTLLAREGIDVVLLEAVKHPREHVGESMLPSMRHYLRFIDLESEYDARKFMHKPGAAFKFVHGQRECYTDFKILGPDRTTWNVFRAEADELMLRHAASQGVKIFEETRVESITFSESVDNSVSPESRPIAASWKNKSGQVGKISFNWLIDASGRQGIMSTKYMKNRIYREGLRNVAAYGYWKDVTVFEEGGPRSNAPWFECLTDREGWAWLIPLHNGTTSIGVVMHQDTSNRKKAEGPSGLEQHYLSQLKLAPGVQDLIGSKGSYVPGSVKSTADYSYHATEYSGDHYRIIGDAAAFVDPLFSSGVHVAMTGALSAASTILGSMKGQVTEVEAQAWHDAKIGICQTRFLLVVLSAYRQMQHVGNKALLDDVNASNFDAAFSLFRPIYQGEHDTSTSLTNEELSKMIEFTRNLFTPTTHQQYNEVKQRVGDLIALSGPVMPSDELDKVLDSDDSDAKAVLKRINSLKVLRNDTSPESFTSEAVNGYVVNLERGQLGLVRA
Protein: Uncharacterized protein (Q38EI1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Intraflagellar transport protein 140
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 80
- Intraflagellar transport
- Intraflagellar transport protein IFT88, putative
- Intraflagellar transport protein A1
- IFT80/172/WDR35 TPR domain-containing protein
- Intraflagellar transport protein component, putative
Sequence:
MMFYAREKLWRHAELVCTDTIKSTDSWLFRVWRALCYDKQGQPNEALREYKSAQQHRETVIPALMGIVLIYRRSKDTEGLASAERALAAYADGDTAANSIDGWVQAAALMWLSGDAAGARDILLRYEDVQETHRDECTNLATIRAWVDLSIGRGAFLEKCGSLFQKVMNMESQNGEPMDIDSTMGRVAFFERKYQFFPAQQLLNKLIVSHPSFTPALIVKARHLMKAEDWEQCTETTKRILGKDKTNLEALALNTLFLLVKDARYEAAAAQLPSLFEALQEKEPKNAALFFEYAQCFSRLSGSYPPLLGVTMQFAEAAHRMAPQRGEYLTEVGFQQLLRGEYKTALATFKKASASADSSVLPLLGLIRCLIFTGNLDDAAKQIEFPNEIQASNQRNPELSALNAILQWRRHRNESKALHFLDQTAEAIRQEVGSGSSGLELYIKLNPPLMLEVAKEYMHHCRTEPPDPTVSKADPIAEKCKRHLELLLRHVPGCLEGQLLLSKVYFVSGNLNKAQAMITTNIRHEHAIPDAFLLSAQICQYVGNVSLASQALEQALTLDFEVKDQPLYNLLYGSVLGMMNKHKEALEALQEALKVVKDKSHVTAKGRLVQPLSVQDHVSLYLLIAQTHLKLHDAEEARATVAEATALFKDTAQAGRVAIASAMIAARTDVDRALEILRQVPPRSDFFIAAKTRMANIYLIHRQNRQMYAECFEQLVEEVATAQSYIALGEAYTNIQEPEKSISAYEKAKAIDPDNSDLAVLIGRALVSTHDYQRAIRYYRDAVASDKSKFAVRADLATLFWHLGAVDHAIAVLKEAPAYQSEPDVGEGVDRAIERVNCALLMCKINRNTQNADLAAEALLQARGFQEHVLRNMMRNETRETIYQQKVVAATISLELGRYYASVGEVERAKECYQESRMYDESSEAPILASARLLLQCGDENACEEQCNAVLRINPACEEAVVILADLMVRRNCFDDAANHFSQLLEKTPNNYEALVQYVQLLRHAGRLSDAKIVLERAESMLDVGQRPDAALSFARGLYHRYCQESTEALRAFNAARLRSDDTQWSEKALVNMIEMYLVPTNEELWVDTQMGDEDRNENVKVAERLLMQMAPGETRDILQGYCWVASKKRQLVERAIKEFTRICTAAERNAGQSEKANNKEPQKEADNAADDEDSKLLSDVNEPPAYTGRMNVHARVGLAIAYFISGLEKKATAELKPIVLLPFDPTTSDSVHRARLLSAHMSVQKKDVKMAKMMLQKALELNKSCPRVCLLLGACHELEENHSEAANCYKDAWLLTKERDPSVGYKLAFHLMKSGKLLQAIEVCRKVLEAHPSYPKISDVVDVCHSLLRP
Protein: UEV domain-containing protein (Q382M1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFDDASRFFARSNYHKPDVLRRIANDLSLLCNMYHLSCRVSPWGGTQQLKLCVYGGLPISVRCCVEAAEQTKNDGGKSKFVLPVQIWLTQQFPIDPPSIFIHCNEPGCKVLSNHKYVDVTGRCHTPELAGWRPTSSSLVSVISGLKELLEEENISPLCVDRNFLNVLALEQRASLVASQDVDAECLSQTGGENAQCVICFGPKDTVLVPCGHYCLCVSCASNLSQCPVCREVTKFRQRVYN
Protein: Glutathione reductase, cytosolic (GR) (GRase) (EC 1.8.1.7) (OBP29) (P48641)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maintains high levels of reduced glutathione in the cytosol.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Glutathione synthetase, chloroplastic
- Glutathione hydrolase 2
- NADPH-dependent thioredoxin reductase 3
- Glutathione hydrolase 1
- Putative inactive glutathione hydrolase 4
- Glutathione hydrolase 3
- Glutathione reductase, chloroplastic
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
Sequence:
MARKMLVDGEIDKVAADEANATHYDFDLFVIGAGSGGVRAARFSANHGAKVGICELPFHPISSEEIGGVGGTCVIRGCVPKKILVYGATYGGELEDAKNYGWEINEKVDFTWKKLLQKKTDEILRLNNIYKRLLANAAVKLYEGEGRVVGPNEVEVRQIDGTKISYTAKHILIATGSRAQKPNIPGHELAITSDEALSLEEFPKRAIVLGGGYIAVEFASIWRGMGATVDLFFRKELPLRGFDDEMRALVARNLEGRGVNLHPQTSLTQLTKTDQGIKVISSHGEEFVADVVLFATGRSPNTKRLNLEAVGVELDQAGAVKVDEYSRTNIPSIWAVGDATNRINLTPVALMEATCFANTAFGGKPTKAEYSNVACAVFCIPPLAVVGLSEEEAVEQATGDILVFTSGFNPMKNTISGRQEKTLMKLIVDEKSDKVIGASMCGPDAAEIMQGIAIALKCGATKAQFDSTVGIHPSSAEEFVTMRSVTRRIAHKPKPKTNL
Protein: Synaptotagmin-16 (Synaptotagmin 14-like protein) (Synaptotagmin XIV-related protein) (Q7TN83)
Organism: Mus musculus (Mouse)
Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
Interaction partners:
Sequence:
MVLTMASQDVQNFFQPLSSWLSRVYEALQQAGDALSASLVLLSKHDSALSDKPEQDLDAAQIQQTYLEDEEQDHDGSPEEASSLFLEEDHFSLSNSDLQDSVQTASPTLGQQAEDSSSVIPPWPSKIPGAPKPQPVLSSIAEEDHHSERQRCGRQHGSGTLEKVNGRKQVNSFGDDEEPSTSSESDEDVTKQFKISVSRSQSFRSGVSEKGKTTELEQKIKCKRLLCTHQEDSAEGSACEDLDRTSQLSYSEILSYEDRPISILPQSPFESRNVRHHGPCRPEMGMVRSLGRPCADGVLETETAFVSRGFEDSYATHSSSLWSPEEQDGTSLQVPHRLLEPISKCGDLDVIFEYRAVTQKLTVTIVRAQGLPDKDRSGVNSWQVHIVLLPSKKQRGKTNIQRGPNPVFKEKVTFTKLEPRDVASCAVRFRLYAARKMTRERMMGEKLFCLSHLHPEGEMKVTLVLEPRSNLSSGESPLSPSVVSHSDSASSTQSLSHGGVPELLVGLSYNATTGRLSVEMIKGSHFRNLAANRAPDTYGKLFLLNCVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISIYSRRTMKRKEMIGWVALGQNSSGEEEQEHWEEMKESKGQQTCRWHTLLES