wanglab/gogpt-training-data huggingface dataset:
Protein: Brivido-3, isoform C (X2JI61)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase MINDY
Sequence:
MKVKKTHWAMFAITVGIIIGCMICIAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDRALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYFLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHVSRPVSAEDALLEYKDRGDKMVNVHYILNIQLTLIRMFLFDEYVEWPQEQQKQPEAQDPDPNLGPDGSPPQDKRQDEAEA
Protein: cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) (Q96UX3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- 2-dehydropantoate 2-reductase
- Integral membrane protein
- Adenylate cyclase
- Serine/threonine protein kinase ypkA
- Serine/threonine protein kinase, putative
- Glutamate synthase
- Ribosomal RNA-processing protein 43
- Aquaglyceroporin, putative
Sequence:
MADSSSFPGTNPFLKVSTKDDKYSPIQKISEEEEYEVTSPTDPTFRSAHSGATAPTAGNSFNGDNGSNEGGEGIQFNRPFDAGFGQGSEGQGEHVEPPGGARPTAAANQGFPNNYALGRRTSVSAESLNPTSAGSDSWTPPCHPKTEEQLSRLKTAVSNNFLFSHLDDDQFRTVLDALVEKPIPAKDIKVISQGDAGDYFYIVENGHFDVYINPAGSVQPGPDGIGNKVSTIGPGGSFGELALMYNAPRAATIVSADPKSTLWALDRITFRRILMDSAFQRRRMYEAFLEEVPLLSSLKPYERAKIADALDAIKYPAGSTIIEEGAPGDAFYLLESGEAEAFKKDVEGPVKSYRRGDFFGELALLDDKPRAASVVAKTDVKVARLGRDGFKRLLGPVEDIMRRAEYSAKPSPS
Protein: Uncharacterized protein (Q583E6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Large ribosomal subunit protein bL21m
- GTP-binding protein, putative
- Tetratricopeptide repeat
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Large ribosomal subunit protein uL4m
- 50S ribosomal protein L13, putative
- Uncharacterized protein
Sequence:
MFTVSCNVAFLCHPAVHHSLLLLRALRQRHTLAIERMGANVTNIGGTVSLSQCGNHISIVPPNLHGSKCVTSGGSIGTVGESPLCVAEHGLQRVHDPQHILYLFSSASPVRQSALDEQIQSYLNAVVVSNQVLRAADDVLIALSIGEMEAVRQTHGNLIDCVAALDASLQQTTENEEGGGGNGATQEVDCLSTWPLFTTIQFLVEEGGLPLGPFPRMSRAYYRLKESTPVVAHSQLVWRTFELSRGPEGPTGELPAWPHRGFLRDIQKQIAEYTTDPPERIMAGVTGEKGPLRARVSGARLGLQRTPARIPWTMQGLHR
Protein: Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) (Q7Z2K6)
Organism: Homo sapiens (Human)
Function: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6UPR8}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLALYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNMVFFDVLGLFVIAYPSRIGSIINYMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGITLISWFTSLVTVLIIAVFISLIGQSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEVFFDISLFVHCCFLVTLTYQGLCSAFISAVWVAFPLLTKLCVHKDFKQHGAQGKFIAFYLLGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKTMLTLTLVCAITFLLVCSGTFFPYSSNPANPKPKRVFLQHMTRTFHDLEGNAVKRDSGIWINGFDYTGISHITPHIPEINDSIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFWIEVQVSEEHPEGMVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF
Protein: Excinuclease cho (EC 3.1.25.-) (Endonuclease cho) (UvrC homolog protein) (P76213)
Organism: Escherichia coli (strain K12)
Function: Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. In vitro, the incision activity of Cho is UvrA and UvrB dependent. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair.
Interaction partners:
- UvrABC system protein B
- UvrABC system protein A
- NH
- Inner membrane protein YdjM
- DNA mismatch repair protein MutS
- UvrABC system protein C
Sequence:
MVRRLTSPRLEFEAAAIYEYPEHLRSFLNDLPTRPGVYLFHGESDTMPLYIGKSVNIRSRVLSHLRTPDEAAMLRQSRRISWICTAGEIGALLLEARLIKEQQPLFNKRLRRNRQLCALQLNEKRVDVVYAKEVDFSRAPNLFGLFANRRAALQALQTIADEQKLCYGLLGLEPLSRGRACFRSALKRCAGACCGKESHEEHALRLRQSLERLRVVCWPWQGAVALKEQHPEMTQYHIIQNWLWLGAVNSLEEATTLIRTPAGFDHDGYKILCKPLLSGNYEITELDPANDQRAS
Protein: Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) (Q10316)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular location: Cytoplasm, cytoskeleton, actin patch.
Interaction partners:
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 1
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Protein dip1
- Actin-binding protein wsp1
- Actin
- Structure-specific endonuclease subunit slx4
Sequence:
MTFRTLDVDSITEPVLTEQDIFPIRNETAEQVQAAVSQLIPQARSAIQTGNALQGLKTLLSYVPYGNDVQEVRTQYLNAFVDVLSNIRAADIPAFVKECSTEEIDNIVNFIYRGLANPQAYNSSVLLNWHEKVVEISGIGCIVRVLNSRPDL
Protein: F18B13.21 protein (Tetratricopeptide repeat (TPR)-like superfamily protein) (Q9SSC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Copper-binding family protein
- F-box protein PP2-A15
- Putative F-box protein PP2-B8
- NAC domain-containing protein 96
Sequence:
MLLRSTSAPILNSWLPQHCSRESSPEPESQLWRRSTSLSLFSSKSIDGHTGEQLHQALSDNKEIIILKSKSNEHSYKTPTSSRQRRSSLDETRYTKKTLDRSSPFLVERLFSSSGQGDKASSNDRLETLVSGGGGGMGGSGGNICNGGGGVGGSGVDGGRSEDATDTYYREMIDSNPGNSLLTGNYAKFLKEVKGDMKKAEEYCERAILGNTNDGNVLSLYADLILHNHQDRQRAHSYYKQAVKMSPEDCYVQASYARFLWDVDEDEEDEALGEEEENLSDETGHVPPTTMFRDFPQHTSITASS
Protein: Keratin-associated protein 27-1 (Q3LI81)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 24-1
- Keratin-associated protein 25-1
- Keratin-associated protein 26-1
- Keratin-associated protein 15-1
- Keratin-associated protein 20-1
- Small cysteine and glycine repeat-containing protein 1
- Keratin-associated protein 20-2
- Keratin-associated protein 8-1
- Keratin-associated protein 13-3
- Keratin-associated protein 1-4
Sequence:
MPHSHCHSLRSFHNAPPLSAITHGTNPITFEDRLCLPSSFHSRTCFLDNFQETCNETTSCQMTNCEQDLFTDDSCVQSNCFPGVVQTTYSNSRPCERTACQSESSSAGLACVSQPCQSESTQQMGFVAQSCQPASLKGNSCPPKTSKSKNFETLERASSQCQCQSQNPESSSCRPLVNVAPEPQLLESSPGVEPTCCVTGGSQLPSK
Protein: RNA-binding protein with serine-rich domain 1 (H3BMM9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVR
Protein: Heparan sulfate glucosamine 3-O-sulfotransferase 2 (EC 2.8.2.29) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2) (Heparan sulfate 3-O-sulfotransferase 2) (Q80W66)
Organism: Rattus norvegicus (Rat)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). May contribute to the pineal circadian physiology.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDGLGQSRLLGAPRCLRGPSASGQKLLAKSRPCDPPGPTPSEPSAPSAPAAAAPAPRLSGSNHSGSPKPGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLETQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRNRSLGLVDVSWNAIRIGMYALHLESWLRYFPLAQIHFVSGERLITDPAGEMGRIQDFLGIKRFITDKHFYFNKTKGFPCLKKPESTLLPRCLGKSKGRTHVQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE
Protein: Ras-related protein Rab-3 (Q94986)
Organism: Caenorhabditis elegans
Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rab-3-interacting molecule unc-10
- Liprin-alpha
- Synaptotagmin-1
- Vesicular acetylcholine transporter unc-17
- Variant SH3 domain protein
- Synaptobrevin-1
- ATP-grasp domain-containing protein
- Rabphilin-1
- C2 domain-containing protein
- Phorbol ester/diacylglycerol-binding protein unc-13
Sequence:
MAAGGQPQGATPGQPDQNFDYMFKLLIIGNSSVGKTSFLFRYCDDSFTSAFVSTVGIDFKVKTVFRGDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWCTQIKTYSWENAQVVLVGNKCDMDSERVVSMDRGRQLADQLGLEFFETSAKENINVKAVFEKLVEIICDKMAESLDKDPQQQPKGQKLEANPTQKPAQQQCNC
Protein: Polygalacturonase inhibitor 1 (Floral organ regulator 1) (Polygalacturonase-inhibiting protein 1) (PGIP-1) (Q8GT95)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Inhibitor of fungal polygalacturonase. Regulates floral organ number.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:P58822}.
Interaction partners:
Sequence:
MASTASFMLAVLLAVAVAAAPARAVRCPPSDKQALMRVKQSLGNPATLSTWSLASADCCEWDHVRCDEAGRVNNVFIDGANDVRGQIPSAVAGLTALMSLSLFRLPGLSGPIPACLTALSNLQFLTISHTNVSGVIPDSLARIRSLDSVDLSHNSLTGPIPNSFSDLPNLRSLDLRSNKLTGCIPAGLVQGQFRSLILSYNQLTGPIPRDDAQDEINTVDLSHNRLTGDASFLFAAGRPIGKVDLSWNDLDFDLSKLVFPPELTYLDLSHNRIRGTVPRSLAALSTLQTLDLSYNRLCGPLPRLHGVIRHGCKPYEHNQCAGGAPLGGCHQS
Protein: At1g23130/T26J12_10 (Polyketide cyclase/dehydrase and lipid transport superfamily protein) (T26J12.10 protein) (O49304)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAQATRQSSLQGELEVDIEIKASAKKFHHMLSGRPQDVAKATPDIQGCALHEGEFGKVGSVIFWNYAIDGQPKVARERIEAVDQEKNLLVLRVIDGDLTKEFKSFLVTIQATPKLRGPGSVVKCHLKYERIDEKVAPPEKLLELFAKLTESMDEMLLSEV
Protein: Profilin-5 (AtPROF4) (AthPRF4) (Q38905)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to actin monomers and regulates the organization of the actin cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate. Acts redundantly with PRF4 to regulate apical actin polymerization at the tip of pollen tube and control polarized pollen tube growth. Functions probably by favoring formin-mediated actin polymerization at pollen tube tips.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Actin-depolymerizing factor 7
- Actin-depolymerizing factor 1
- Actin-depolymerizing factor 12
- Formin-like protein 2
- Actin-depolymerizing factor 9
- Actin-depolymerizing factor 4
- Actin-depolymerizing factor 8
- Actin-depolymerizing factor 5
- Actin-depolymerizing factor 2
- Actin-depolymerizing factor 3
Sequence:
MSWQAYVDEHLMCDVGDGQGHHLTAAAIIGHDGSVWAQSANFPQFKPQEITDIMKDFDEPGHLAPTGMFLAGLKYMVIQGEPNAVIRGKKGAGGITIKKTGQSMVFGLYEEPVTPGQCNMVVERLGDYLIEQGL
Protein: Tau, isoform H (A0A0B4LHR7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MADVLEKSSLLDAVPPLGDPHPPLPHQQLQQEAAAAAAANAAPPAPPQQQQPPPHQLQQQQPQQQQLQQKPANARANQDQKEGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSSKPDKSGTSRPPSATPSNKSAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKGGEKKYWKAPRIQRATTLTSSMSLPAECLVLSVSMPSLNSEPKRPKSAGPKKKPGQAVHSKPFRLY
Protein: Transcription factor RSL2 (Basic helix-loop-helix protein 85) (AtbHLH85) (bHLH 85) (Protein ROOT HAIR DEFECTIVE 6-LIKE 2) (Protein RHD SIX-LIKE 2) (Transcription factor EN 115) (Transcription factor bHLH85) (bHLH transcription factor bHLH085) (Q84WK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in the regulation of root hair elongation. Does not seem to be a direct transcriptional target of RHD6 and RSL1. Involved in the regulation of root hair elongation in response to low phosphate.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:20139979}.
Interaction partners:
- Transcription factor WER
- Homeobox-leucine zipper protein GLABRA 2
- Dof zinc finger protein DOF5.4
- Expansin-A7
- Auxin response factor 19
- Transcription factor EGL1
- AT1G01800 protein
- Transcription factor GLABRA 3
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH1
- MYB-like transcription factor ETC1
Sequence:
MEAMGEWSNNLGGMYTYATEEADFMNQLLASYDHPGTGSSSGAAASGDHQGLYWNLGSHHNHLSLVSEAGSFCFSQESSSYSAGNSGYYTVVPPTVEENQNETMDFGMEDVTINTNSYLVGEETSECDVEKYSSGKTLMPLETVVENHDDEESLLQSEISVTTTKSLTGSKKRSRATSTDKNKRARVNKRAQKNVEMSGDNNEGEEEEGETKLKKRKNGAMMSRQNSSTTFCTEEESNCADQDGGGEDSSSKEDDPSKALNLNGKTRASRGAATDPQSLYARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSSDDLWMYAPIAFNGMDIGLSSPR
Protein: Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (P50284)
Organism: Mus musculus (Mouse)
Function: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 14
- Lymphotoxin-beta
- Lymphotoxin-alpha
- TNF receptor-associated factor 3
- TNF receptor-associated factor 2
- Mitogen-activated protein kinase kinase kinase 14
- Tumor necrosis factor receptor superfamily member 13C
- Tumor necrosis factor
- CD40 ligand
- TNF receptor-associated factor 5
Sequence:
MRLPRASSPCGLAWGPLLLGLSGLLVASQPQLVPPYRIENQTCWDQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVCKTCPHNSYNEHWNHLSTCQLCRPCDIVLGFEEVAPCTSDRKAECRCQPGMSCVYLDNECVHCEEERLVLCQPGTEAEVTDEIMDTDVNCVPCKPGHFQNTSSPRARCQPHTRCEIQGLVEAAPGTSYSDTICKNPPEPGAMLLLAILLSLVLFLLFTTVLACAWMRHPSLCRKLGTLLKRHPEGEESPPCPAPRADPHFPDLAEPLLPMSGDLSPSPAGPPTAPSLEEVVLQQQSPLVQARELEAEPGEHGQVAHGANGIHVTGGSVTVTGNIYIYNGPVLGGTRGPGDPPAPPEPPYPTPEEGAPGPSELSTPYQEDGKAWHLAETETLGCQDL
Protein: Formyltetrahydrofolate deformylase 1, mitochondrial (EC 3.5.1.10) (Q93YQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Deformylase involved in photorespiration. Prevents excessive accumulation of 5-formyl tetrahydrofolate (THF), a potent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:18628352}.
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
- Bifunctional dihydrofolate reductase-thymidylate synthase 1
- Serine hydroxymethyltransferase 1, mitochondrial
- Serine hydroxymethyltransferase 6
- Serine hydroxymethyltransferase 3, chloroplastic
- Serine hydroxymethyltransferase 7
- Serine hydroxymethyltransferase 5
- Serine hydroxymethyltransferase 2, mitochondrial
- Aminomethyltransferase, mitochondrial
Sequence:
MIRRITERASGFAKNIPILKSSRFHGESLDSSVSPVLIPGVHVFHCQDAVGIVAKLSDCIAAKGGNILGYDVFVPENNNVFYSRSEFIFDPVKWPRSQVDEDFQTIAQRYGALNSVVRVPSIDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERASNTHVMRFLERHGIPYHYVSTTKENKREDDILELVKDTDFLVLARYMQILSGNFLKGYGKDVINIHHGLLPSFKGGYPAKQAFDAGVKLIGATSHFVTEELDSGPIIEQMVESVSHRDNLRSFVQKSEDLEKKCLTRAIKSYCELRVLPYGTNKTVVF
Protein: Syntaxin-112 (AtSYP112) (Q9ZPV9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vesicle trafficking protein that functions in the secretory pathway.
Interaction partners:
- UPF0235 protein At5g63440
- VAMP-like protein YKT62
- SNAP25 homologous protein SNAP33
- SNAP25 homologous protein SNAP29
- Syntaxin-31
- Putative SNAP25 homologous protein SNAP30
- Membrin-11
- Syntaxin-52
- Novel plant SNARE 13
- Syntaxin-21
Sequence:
MNDLMTKSFLSYVELKKQARTDMESDRDLEKGEDFNFDFSPADEENLSGFFQEIETIKTLIEEITHLLLDLQNLNEETKSTHSTKILRGLRDRMESNIVTISRKANTVKTLIETLEKRNVANRTSFKEGSCVDRTRTSITNGVRKKLRDTMSEFHRLRERIFADYREDLKRKYFLATGEEPSNEDMEKMISGSGSCSDLVKTFEVKPEMDLKTKERHEAVNDIKRSLNRLHQVFLDMAVLVETQGDRIDDIEANVANAGSFVSGGTNSLYYANQMKKKTKSWVLWVSILGVLILLVCVISMLASR
Protein: Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) (O00300)
Organism: Homo sapiens (Human)
Function: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Subcellular location: Secreted.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 11
- Tumor necrosis factor ligand superfamily member 10
- Tartrate-resistant acid phosphatase type 5
- Tumor necrosis factor receptor superfamily member 11A
- Runt-related transcription factor 2
- Transcription factor Sp7
- Collagen alpha-1
Sequence:
MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL
Protein: Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) (P34514)
Organism: Caenorhabditis elegans
Function: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis.
Interaction partners:
- Abnormal embryogenesis protein 30
- Cell division cycle protein 23 homolog
- Anaphase-promoting complex subunit 11
- Cell division cycle protein 16 homolog
- Anaphase-promoting complex subunit 10
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 1
- Protein gfi-3
- Fizzy-related protein homolog
Sequence:
MSIFDRMTTSKEAAMKYRQFCVSKKKEVWDALIYHAKYAKNIEKVYDMTTVLQRVQQECLMFALEKGVGQPDIRDAAELIFPLAMQKVVIKVLRPYFMSHFTNYRLAMYLPHRKIDHGIDLNQELWTPEKKEICGQYVQDFNPFVNELKTGILNANRHMNAALSVYIRELAATLVMHEKAAFDNELRCSMFQEIMESLRIWSDQVTMQDAFHLISDTIYKDVFQMLSKNAYEMIAVDFPVKFRSLITMKYCLLRTNNHGRVDFTNYLIDQVNTKLLVASVDTKDILKAYAACVESLREMDNSCVVMHKVCGVIREYLKRRPDTVQQIISYITSNKKNELEKDMSLQSKTVRSAMMDEEELKGVNDDFLPENMETLGWENWMPNPTDATVGDGAPGHQGVDVFNMLVSVYGSKELFVKEYRNLLAERLSSSDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDVIHSLDIDKKFEDMSERSAGNYDVPIIPISACIISSHYWPKLETEKTEALMPQPLQAAMDVYQETYLDVKRDRKLEWLRSVGCVEVSINIDGVEVDRTIPNMYALLLFLFLEKETWTTAEVVEKMGMSVVVTRKRLEWLVKQGFICMNPIISSDTWTLTRNPSGISIVRPGTPDLEDDEDVEPEENSDMVDALEQYWGYTRNFIANHAPNGEVKAERMHRVYRMFGSPTSAGPTLDHVSAFLQRKVALGLLTCINGSYRIIQEKKDGE
Protein: Cell surface receptor daf-1 (EC 2.7.11.30) (Abnormal dauer formation protein 1) (P20792)
Organism: Caenorhabditis elegans
Function: Probably involved in a TGF-beta pathway. May be a receptor for TGF-beta-like ligand daf-7. Controls the decision of whether or not larvae enter a developmentally arrested state, known as dauer, in response to environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Cell surface receptor daf-4
- Dauer larva development regulatory growth factor daf-7
- Protein dbl-1
- Dwarfin sma.
- Smad protein daf-8
- Ski protein homolog
- Smad-related protein daf-14
- TGF-beta family profile domain-containing protein
- TGF-beta family profile domain-containing protein
- BMP-like protein unc-129
Sequence:
MRIRHVVFCLLALVYGAETSDDDLDERTNIFIRDKLIPALKLAEVTKVNFTRLHLCHCSREVGCNARTTGWVPGIEFLNETDRSFYENTCYTDGSCYQSARPSPEISHFGCMDEKSVTDETEFHDTAAKVCTNNTKDPHATVWICCDKGNFCANETIIHLAPGPQQSSTWLILTILALLTFIVLLGIAIFLTRKSWEAKFDWYIRFKPKPGDPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDERQQLLLDKKAKAVAQTAGVTVQDRKILGPQKPKDESPANGAPRIVQKEIDREDEQENWRETAKTPNGHISSNDDSSRPLLG
Protein: Forkhead box P, isoform C (A0A0B4K6N2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MHRIHDDEYSEDAKESDFKSSIQKEISVKSRHQISIPDICSDAVKNNCFPPTGFLNNSITFASHVVKCSSPASSIDESSTAAQQHESNPHMHIQGQHMMAPVPDLGFYNVPEFISEQEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVPGREGKFCRSPLTVNSIGRPIRQTNSPSPLNLPMVNSTNLCSIKKRNHDKNTFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEPSSSPNSCQSGNGVPTDKNPCDNCTQHCTSLPPGADNPLDSNNPNDLGRIGCLPYCGSDGLSKASKDYSNMDSGMIESNSHLTIDEYSTNMYESSANEHNR