Protein: CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Q9JLH5)
Organism: Rattus norvegicus (Rat)
Function: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8K389}. Golgi apparatus {ECO:0000250|UniProtKB:Q96SN8}. Cytoplasm {ECO:0000250|UniProtKB:Q96SN8}. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localization to centrosomes versus Golgi apparatus may be cell type-dependent. Due to the probable lack of interaction with EB1/MAPRE1, its localization to microtubule plus ends may not be conserved in rats. {ECO:0000250|UniProtKB:Q96SN8, ECO:0000305|PubMed:19553473}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Centrosomal P4.1-associated protein
Sequence:
MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVLPIMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKKNIELKVEVESLKRELQERDQLLVKASKAVESLAEGGGSEIQRVKEDARKKVQQVEELLTKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEEKDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEERQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKEVEELNSIIKELTADSTQSREAPLKTQVSEFEVRESENCEAALAEKEALLAKLHSENVTKNTENHRLLRNVKKVTQELNDLKKEKLRLERDLEEAHREGNRGARTIHDLRNEVEKLRKEVCEREKAVEKHYKSLPGESSSKFHSQEQVVKGLTESASQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKTEQNVYAHLAKNLQDTDSKLQAELKRVLALRKQLEQDVLAYRNLQTALQEQLSEIRKREEEPFSFYSDQTSYLSICLEEHSQFQLEHFSQEEIKKKVIDLIQLVKDLHADNQHLKKTIFDISCMGVQGNDRLESTKQAELMASKADEDTLKFKADDENHFQSDQHLEQSREIMEDYAEGGGKDGYVRHMDSNILDHDGAHTPDTSEDHSLEDELLSLLATFFSKKATPSLESRPDLLKALGALLLERICLAEQGSPGDHSDSKAEKALEQVAVRLRDELGHSCLANSFSKSHSELKSPRGTWLVKTGDEAKVELKSVSVQTMTIEDSTRGFKPERKREAWAGKPEEAVFSTELESEALGEMPGLQATHLSFPSAIDKDDQKTGLLIQLKTPELLENLYNLPASQEVVAQLQGQVLELQKELKEYKIRNKQLLDKLILAEAMMEGMAVPNSTPVNVPAAQAVVRTAFQGKPGEQEGHETTHSAGRDKEVDSDQYTSFEIDSEICPPDDLALLPACKENLEDFLGPPSIATYLDSKSQLSVKVSVVGTDQSENINLPDDTEALKQKIHDLQTELEGYRNIIVQLQKHSQCSEAIITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEIIDGKMLESLKQQLVEQEQELQKEQDLNLELFGEIHNLQNKFRDLSPSRYDSLVQSQARELSLQRQQIKDSHDICVVCHQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLEKLFLHGKSARVEPHTQTELLRRLRTEEDNLPYQHLLPESPEPSASHALSDDEMSEKSFLSREPKPDSETEKYPTIASRFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGCETDQGSTNVSAYSSELHNSLTSEIQFLRKQNEALSTMLEKGSKEKQKENEKLRESLARKTESLEHLQLEYASVREENERLRRDISEKERQNQQLTQEVCSSLQELSRVQEEAKSRQQLLLQKDELLQSLQMELKVYEKLAEEHQKLQQESRGEACGGGQKGQDPFSNLHGLLKEIQVLRDQAERSIQTNNTLKSKLEKQLSQGSKQAQEGALTLAVQALSVTEWSLQLDKHDVNKCPEASDNSFDLFESTQAMAPKSASETPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRHLWASKSGHHMLCLIEDYDALYKQISWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVPLSKFLSSMNTAKLILEKASRLLKLFWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLFEQEKKLQNTAKLLQQSKHQEKIIFDQLVITHQVLRKARGNLELRPRAAHPGTSSPSRPGS