wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome c oxidase subunit 6A, mitochondrial (Cytochrome c oxidase polypeptide VIa) (Q20779)
Organism: Caenorhabditis elegans
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P32799}; Single-pass membrane protein {ECO:0000250|UniProtKB:P32799}.
Interaction partners:
- Cytochrome b-c1 complex subunit 7
- Cytochrome oxidase c subunit VIb
- Cytochrome c oxidase subunit 4
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase polypeptide VIIc
- COX5B-domain-containing protein
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 1
Sequence:
MNRLAQPATRSVVKTFQRKSSGSFYGSNNVEGFKESYVTPLKQAHNASETWKKIFFIASIPCLALTMYAAFKDHKKHMSHERPEHVEYAFLNVRNKPFPWSDGNHSLFHNKAEQFVPGVGFEADREKH
Protein: Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) (Q6DWJ6)
Organism: Homo sapiens (Human)
Function: Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Probable non-functional immunoglobulin heavy variable 3-16
Sequence:
MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
Protein: Oxygen-evolving enhancer protein 2 (OEE2) (23 kDa subunit of oxygen evolving system of photosystem II) (23 kDa thylakoid membrane protein) (OEC 23 kDa subunit) (P83687)
Organism: Euglena gracilis
Function: May be involved in the regulation of photosystem II.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:12837550}. Note=Associated with the photosystem II complex.
Interaction partners:
Sequence:
AYGEGANVFGKRKETDQFFEISGDGWSGKL
Protein: Spatacsin (C4B7M2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWEDSRNSSTPTEKPKLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPERDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDVAVIVSSSNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCAPWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTITLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENRQLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKELFIHTEELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEELIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEKLYLGHFQENMQIQSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWIGEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQDTLPVQNYKTKEGWDFHSQFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPSRLFGWQSANTLAIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLELLGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQQEIKRLSSESSSQWALVVQFCRLHNMKLSISYLRECAKANDWLQFIIHSQLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTDLFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVATEAMGHIQDSTEDHTWNLEDLSVIWRTLLTRQKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELGKLLQLFVEREHLFSDGPDVKKLCILCQILKDTSIAINHTIITSYSIENLQHECRSILERLQTDGQFALARRVAELAELPVDNLVIKEITQEMQTLKHIEQWSLKQARIDFWKKCHENFKKNSISSKAASSFFSTQAHVACEHPTGWSSMEERHLLLTLAGHWLAQEDVVPLDKLEELEKQIWLCRITQHTLGRNQEETEPRFSRQISTSGELSFDSLASEFSFSKLAALNTSKYLELNSLPSKETCENRLDWKEQESLNFLIGRLLDDGCVHEASRVCRYFHFYNPDVALVLHCRALASGEASMEDLHPEIHALLQSAELLEEEAPDIPLRRVHSTSSLDSQKFVTVPSSNEVVTNLEVLTSKCLHGKNYCRQVLCLYDLAKELGCSYTDVAAQDGEAMLRKILASQQPDRCKRAQAFISTQGLKPDTVAELVAEEVTRELLTSSQGTGHKQMFNPTEESQTFLQLTTLCQDRTLVGMKLLDKISSVPHGELSCTTELLILAHHCFTLTCHMEGIIRVLQAAHMLTDNHLAPSEEYGLVVRLLTGIGRYNEMTYIFDLLHKKHYFEVLMRKKLDPSGTLKTALLDYIKRCRPGDSEKHNMIALCFSMCREIGENHEAAARIQLKLIESQPWDINNISLLTWSWKT
Protein: T3SS secreted effector NleH (Q8XAL6)
Organism: Escherichia coli O157:H7
Interaction partners:
- T3SS secreted effector NleH
- T3SS secreted effector NleH
- Effector protein NleF
- T3SS secreted effector NleA/EspI
- T3SS secreted effector EspL
- Protein-arginine N-acetylglucosaminyltransferase NleB1
- Cysteine S-methyltransferase NleE
Sequence:
MLSPSSINLGCSWNSLTRNLTSPDNRVLSSVRDAAVHSDSGTQVTVGNRTYRVVVTDNKFCVTRESHSGCFTNLLHRLGWPKGEISRKIEAMLNTSPVSTTIERGSVHSNRPDLPPVDYAQPELPPADYTQSELPRVSNNKSPVPGNVIGKGGNAVVYEDMEDTTKVLKMFTISQSHEEVTSEVRCFNQYYGSGSAEKIYNDNGNVIGIRMNKINGESLLDIPSLPAQAEQAIYDMFDRLEKKGILFVDTTETNVLYDRMRNEFNPIDISSYNVSDISWSEHQVMQSYHGGKLDLISVVLSKI
Protein: Na,K-ATPase alpha subunit isoform 1c/i (Q5IR98)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTSFDRSSATWAALARVAGLCNRAVFLAEQSGIPILKRDVAGDASESALLKCIELCCGSVQGMRDQYTKVAEIPFNSTNKYQLSVHLNKNEGESKHLLVMKGAPERILDRCSTILIQGKEQPLDDEMKDSFQNAYMELGGLGERVLGFCHFQLPDDQFAEGFQFDCEEVNFPTENLCFVGLM
Protein: Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1) (Q13445)
Organism: Homo sapiens (Human)
Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Subcellular location: Cell membrane {ECO:0000305|PubMed:8621446}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:23319592}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Transmembrane emp24 domain-containing protein 10
- Transmembrane emp24 domain-containing protein 9
- Interleukin-1 receptor-like 1
- Transmembrane emp24 domain-containing protein 2
Sequence:
MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT
Protein: C2 domain-containing protein (Q86JM8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MMQAPMIAATNPNCPIAIVANHKLSLPPGACPFVVNPNGNGKIRIRLISASNLISADANGYSDPYIKVKSTSIDSMKVTKVIEKNLNPVWNEEVVLDISSVGRELFIFDVYDSDKVGNDDLLGFVGVDLSLLPLGIEVLTCENLSFAKHGVLQIGITALDFGLTNIPPNYLHAYTEWRNTLPGHQRKEFKKLKKHKDSCGPYANKVVHEDYKVTNGYLKRKKSKREKTAKGFVKGLKIAGKVSLKVLDSATEDD
Protein: Protein RecA (Recombinase A) (P14582)
Organism: Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Function: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
Interaction partners:
- DNA polymerase I
- LexA repressor
- DNA repair protein RadA
- DNA topoisomerase 1
- Beta sliding clamp
- DNA repair protein RecN
- DNA helicase RecQ
- Holliday junction branch migration complex subunit RuvB
- SNF2 helicase, putative
- Crossover junction endodeoxyribonuclease RuvC
Sequence:
MSAISNNPDKEKALNLVLNQIERNFGKGAIMRLGDAAQMKVATIPSGALTLDQAMGGGFPRGRIVEIYGPESSGKTTVALHAIAEVQKAGGVAAFIDAEHALDPTYSAALGVDIENLLVAQPDNGESALEIADQLVRSAAVDLIVIDSVAALVPRAEIEGEMGDVQVGLQARLMSKALRKIAGNMGRSGCTVIFLNQLRQKIGISYGNPEVTTGGTALKFYASVRLDIRRIQTLKKGSEGEFGIRAKVKVAKNKVAPPFRIAEFDIIFGKGISRVGCMLDLAEQTGVITRKGAWYSYEGDNIAQGRDNAVKYLEENPDVAAIVTQKVRENLDMSSMGFGDEHHTTEEE
Protein: At3g62810 (Complex 1 family protein / LVR family protein) (Q9LZI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL29m
- 50S ribosomal protein L33
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL5c
- Small ribosomal subunit protein mS29
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein mS33
- Large ribosomal subunit protein bL34m
Sequence:
MVTGEALIAYRALLRATKKSFAGDTEMLKASASEIRKKFEENRLVASNSDITRLLEEAREATQFISTMIVQAKLNERGGYEMKASQEHAGATLELPSEEMLRKKSV
Protein: Interleukin-10 (IL-10) (Q6A2H4)
Organism: Gallus gallus (Chicken)
Function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P22301}.
Interaction partners:
- Fibronectin type-III domain-containing protein.
- Uncharacterized protein.
- Interferon gamma
- Interleukin-1
- Interleukin-6
- Uncharacterized protein.
- Interleukin-4
- Uncharacterized protein.
- Ig-like domain-containing protein.
- Ig-like domain-containing protein.
Sequence:
MQTCCQALLLLLAACTLPAHCLEPTCLHFSELLPARLRELRVKFEEIKDYFQSRDDELNIQLLSSELLDEFKGTFGCQSVSEMLRFYTDEVLPRAMQTSTSHQQSMGDLGNMLLGLKATMRRCHRFFTCEKRSKAIKQIKETFEKMDENGIYKAMGEFDIFINYIEEYLLMRRRK
Protein: Plasmodium RESA N-terminal domain-containing protein (C6S3C7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MERSKNKFPVFDEKYIHRDVEKNIGKNNFPMYIYIMLICLIFSILQDDGNYDDIMKDPIIFTHMKKSRILSEYQCIENYNFEEKDENFSNDDIFKNDEKSEYNYSGNVVEDFNFYMDKMNETDDKWIIEKKNIKNDICIKNDPYNKLIFGDTSPDLSESEFNEFINNLDDYVNKNEMYIIWNYVNSKEKFKYLNMQQNIKSYCENLAYNYDIPKDIERNEWLKAYYYMTDILLINENKFHNYFYHLISYGKCDKNFFLEVIDIHINSWRNIRRSMNNLWTKKLNDTFKNHPYVTKK
Protein: Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7) (Q19AV6)
Organism: Homo sapiens (Human)
Function: Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Required for meiotic progression, hence for fertility.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- ATPase SWSAP1
- DNA polymerase delta catalytic subunit
- Serine-protein kinase ATM
- DNA mismatch repair protein Msh2
- Centrin-2
- Mitochondrial inner membrane protease ATP23 homolog
- DNA excision repair protein ERCC-5
- PHD finger protein 21A
- DNA excision repair protein ERCC-1
- DNA ligase 4
Sequence:
MAVVLPAVVEELLSEMAAAVQESARIPDEYLLSLKFLFGSSATQALDLVDRQSITLISSPSGRRVYQVLGSSSKTYTCLASCHYCSCPAFAFSVLRKSDSILCKHLLAVYLSQVMRTCQQLSVSDKQLTDILLMEKKQEA
Protein: Protein LLP homolog (Protein LAPS18-like) (Q9D945)
Organism: Mus musculus (Mouse)
Function: In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:26961175}. Chromosome {ECO:0000250|UniProtKB:Q9BRT6}. Note=Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site (PubMed:26961175). Localizes at the chromosome periphery during mitosis (By similarity). {ECO:0000250|UniProtKB:Q9BRT6, ECO:0000269|PubMed:26961175}.
Interaction partners:
- Thyroid transcription factor 1-associated protein 26
- Large ribosomal subunit protein eL30
Sequence:
MAKSLRSKWKRKMRAEKRKKNAPRELNRLKSILRVDGDALMKDVEEIATVVVAKPRQEKMQCEEGRCDGADEEKDDMKMETEIKRNRKTLLDQHGQYPVWMNQRQRKRLKAKREKKRGKSRAKAAKGLAW
Protein: Calmodulin-related protein 97A (Protein androcam) (P49258)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in calcium-mediated signal transduction.
Interaction partners:
- Neither inactivation nor afterpotential protein C
- Myosin heavy chain 95F
- Inactivation-no-after-potential D protein
- Dynamin
- Tropomyosin-1, isoforms 9A/A/B
- Calmodulin
- Cortactin, isoform A
- Inositol 1,4,5-trisphosphate receptor
- AT09290p
- Transient-receptor-potential-like protein
Sequence:
MSELTEEQIAEFKDAFVQFDKEGTGKIATRELGTLMRTLGQNPTEAELQDLIAEAENNNNGQLNFTEFCGIMAKQMRETDTEEEMREAFKIFDRDGDGFISPAELRFVMINLGEKVTDEEIDEMIREADFDGDGMINYEEFVWMISQK
Protein: Meiotically up-regulated gene 15 protein (P87054)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MNVGDLKSANDLYESVRSIEGVTGVHLFRIRDAGILKSTMIPELDALTTISLDELNKSPTVFTKNLLQGCGGTDLDVPAELKRLVIFVCNILESCNEFTDLGSARLLRLTFDSCQLVIMYDSLFVVAITKDET
Protein: BCL2-interacting killer (Bcl-2-interacting killer isoform X1) (Q5RGV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVEETRQQKNATTLQAGPAEVDHSNLYAFNMRVTQTIGRQLAQIGDEMDNKWRQEPPVPWQNLNFGIYPYVLSRRVFSGILANLWGSKIMPIFRTSWLLPQLQNGCQEARKWAAWVSNLHVSDWSRSTTYTLASALLLVTVSIFLVNWNEYEG
Protein: Uncharacterized protein (Q3UEY5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVPLLLPTKPCAAGHQAGSTGSFPSIPLSPRPAVSTVADPPSPWATPTCTTKTVSPIPHPLSQAWLHQTHQMVDASQNPQGQCLNTWVPGQMTLDRNGAEMVLSLHLGPPLECPGPNPTAVVPLLLTASPQKWPLLQDSYQLNVQHSITLTSCLLSQGMVTG
Protein: RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) (Q6ZN04)
Organism: Homo sapiens (Human)
Function: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
Subcellular location: Nucleus {ECO:0000269|PubMed:18779327}. Cytoplasm {ECO:0000269|PubMed:18779327}. Cytoplasm, P-body {ECO:0000269|PubMed:18779327}. Cytoplasmic granule {ECO:0000269|PubMed:18779327}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
Interaction partners:
- E3 ubiquitin-protein ligase DZIP3
- Protein argonaute-1
- Snurportin-1
- mRNA-decapping enzyme 1A
- Heterogeneous nuclear ribonucleoprotein K
Sequence:
MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSSSAAATQRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGGEASVPSPDGCPELQPTFDPAPAPPPGAPLIWAQFERSPGGGPAAPVSSSCSSSASSSASSSSVVFPGGGASAPSNANLGLLVHRRLHPGTSCPRLSPPLHMAPGAGEHHLARRVRSDPGGGGLAYAAYANGLGAQLPGLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIRIFS
Protein: Proliferating cell nuclear antigen (PCNA) (Q03392)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P15873}.
Interaction partners:
- N-acetyltransferase eso1
- Replication factor C subunit 2
- Postreplication repair E3 ubiquitin-protein ligase rad18
- Flap endonuclease 1
- Replication factor C subunit 5
- Replication factor C subunit 1
- DNA polymerase delta catalytic subunit
- Replication factor C subunit 4
- DNA mismatch repair protein msh6
- DNA polymerase delta subunit 3
Sequence:
MLEARFQQAALLKKLLDAIKELVTDANFDCNDNGISLQAMDSSHVALVSMLIKSDGFEPYRCDRNIALGINLNALSKVLRCAQNEDLVTLKAEDTPEVLNLVFESEKNDRISDYDVKLMDIDQEHLGIPDIEYDATITMPAAEFQRITRDLLTLSDSVTINASKEGVRFSCKGDIGNGSTTLKQHTDLSDQDQSIEISLTQAVTLTFSLKYLAQFTKATPLATRVTLSMSNDVPLLVEYKMESGFLRFYLAPKIGEEDEE
Protein: Enoyl-CoA-hydratase (EC 4.2.1.17) (G4V4T5)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl-CoA thioester. Physiologically, DpgB could act as a dehydratase, facilitating the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate.
Interaction partners:
- 3,5-dihydroxyphenylacetyl-CoA synthase
- 
- Enoyl-CoA-hydratase
Sequence:
MNGELVLRLDGARPLSPASVEELSALCDRAEDDREAGPVTVHVTGVPSAGWTAGLTVGLVSKWERVVRRFERLGRLTIAVASGECAGTALDLLLAADLRIVTPGTRLRLAPVGGSTWPGMSVYRLTQQAGAAGIRRAVLLGTPIEVDRALALNLVDEVSDDPAKTLAGLAEAAAALDGAETAIRRQLIFEDGSTTFEDALGAHLAAADRALRREATS
Protein: STX12 protein (Syntaxin 12) (A7MAZ2)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 4
- Vesicle transport through interaction with t-SNAREs homolog 1A
- STX6 protein
- Syntaxin-8
- Synaptosomal-associated protein 29
- Vesicle-associated membrane protein 2
- Vesicle-associated membrane protein 7
- Synaptosomal-associated protein
- Golgi SNAP receptor complex member 1
Sequence:
MSYGPLDMYRNPGGSGPPLRDFNSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQKLQKERLMNDFSAALNSFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQRQEDEVAITEQDLELIKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATDQLQRAAYYQKKSRKKICILVLVLSVIIVIFGFILWLVNK
Protein: Exchange factor for Arf-6 (Arf guanine nucleotide exchange factor efa-6) (Pleckstrin homology domain-containing protein efa-6) (G5EET6)
Organism: Caenorhabditis elegans
Function: Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:17676955, ECO:0000269|PubMed:21076413, ECO:0000269|PubMed:26339988}. Cell membrane {ECO:0000269|PubMed:26339988}. Note=Present throughout the embryonic cortex during the first embryonic mitosis, but at reduced levels in the posterior cortex (PubMed:21076413). Localizes to the plasma membrane of the soma and processes of neurons. Localizes to the cellular cortex in the steady (uninjured) state. Following injury, transiently relocalizes to the sites marked by the microtubule minus end binding protein ptrn-1 together with tac-1 (PubMed:26339988). {ECO:0000269|PubMed:21076413, ECO:0000269|PubMed:26339988}.
Interaction partners:
- ADP-ribosylation factor 6
- Serine/threonine-protein kinase zyg-8
- Patronin
- GTP exchange factor for ARFs 1
- Calponin homology domain-containing protein
- Microtubule End Binding Protein
- E3 ubiquitin-protein ligase arc-1
Sequence:
MAKVASSGAEEALATIDGAPRRNVKKSEAFVMSGDVLISLNRNVSSTYAKLLGDQLPPGTTVASSIHPHQLSRATASAGVSFPSMNRNGAAAQKLSRLPVPVSTSQIERRGSLARKTSEESSPTAIRMLKTAPIERMESTDVEESEEETVMMTTDEKENQKKPNENDDEVMVVDEEQFIVVSNDMKSPNEEIVAKSLRSAMFTMPTDNHHHSYNSSPQISTLSPHLRSNGDGPSRSPVYDDVDDDLNGSLDAKDMSNNSHQQSFRSPENYSEKDTPSKHSVVTIDGSGVSNHYDQDGMFSHVYYSTQDTTPKHGSPSLRKQIFESRTTPNTAASNSSASASPSLHATSESRGATGGVSLRSAESSNLNQTAVPSTSTNSVGGEREAAQIARNLYELKNCTSTQVADRLNEQNEFSFLILVKYLELFQFSTTRIDAALREFLSRVELRGESSARERLLRVFSARYLECNPAIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTARDFITNIAHTGCTFKREMLKTLFQSIKDNAISLQNSAKNSTANGSVASTSRRQPQQIYEVDPDSVVEYYSGFLMRKYVRETDGGKTPFGRRSWRMVYARLRGLVLYFDTDEHPKATSRYASLENAVSLHHALAEPAPDYKKKSFVFRVRIAHGGEILFQTSNQKELQEWCEKINFVAAAFSSPTLPLPVTSKPETAPMPRLPRIPCLAPITKQLSTHEARVAELNEMIEIVSQSVSPNQPQQLITDRWVLLSFEKRRYSTYINVLRRSLEARKASSATTMNIMMTPTRRQQQNQKPVVSEDRLSYTDAVNGAAAH
Protein: Butyrophilin subfamily 2 member A1 (Q7KYR7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Xanthine dehydrogenase/oxidase
- CD209 antigen
- Perilipin-2
- Lactadherin
Sequence:
MESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAGLGSKPLISMRGHEDGGIRLECISRGWYPKPLTVWRDPYGGVAPALKEVSMPDADGLFMVTTAVIIRDKSVRNMSCSINNTLLGQKKESVIFIPESFMPSVSPCAVALPIIVVILMIPIAVCIYWINKLQKEKKILSGEKEFERETREIALKELEKERVQKEEELQVKEKLQEELRWRRTFLHAVDVVLDPDTAHPDLFLSEDRRSVRRCPFRHLGESVPDNPERFDSQPCVLGRESFASGKHYWEVEVENVIEWTVGVCRDSVERKGEVLLIPQNGFWTLEMHKGQYRAVSSPDRILPLKESLCRVGVFLDYEAGDVSFYNMRDRSHIYTCPRSAFSVPVRPFFRLGCEDSPIFICPALTGANGVTVPEEGLTLHRVGTHQSL
Protein: Growth hormone receptor (Q0R5T6)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
EGKLEEVNTILAIHDNYKHEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHEKSLNIFGAKDDDSGRTSCYEPDILEADFHVSDMCDGTSEVAQPQRLKGEADISCLDQKNQNNSPSNDAAPASQQPSVILVEENKPRPLLIGGTESTHQAVHTQLSNPSSLANIDFYAQVSDITPAGNVVLSPGQKNKTGNPQCDTHPEVVTPCQANFIVDNAYFCEVDAKKYISLAPHVEAESHVEPGFNQEDIYITTESLTTTAGRSGTAEHVPSSEIPVPDYTSIHIVQSPQGLVLNATALP