wanglab/gogpt-training-data huggingface dataset:
Protein: Type III polyketide synthase B (PKS-B) (EC 2.3.1.-) (Hydroxyalkyl alpha-pyrone synthase PKS-B) (Protein LESS ADHESIVE POLLEN 5) (Q8LDM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant type III polyketide synthases (PKSs) that catalyzes the condensation of malonyl-CoA units with various CoA ester starter molecules to generate a diverse array of natural products including long-chain alkyl alpha-pyrones. Accepts up to C(20) chain-length fatty acyl CoAs as starter substrates, and carries out sequential condensations with malonyl-CoA to produce triketide and tetraketide alpha-pyrones, potential sporopollenin precursors. Favorite substrates for are midchain- and v-hydroxylated fatty acyl-CoAs (e.g. 12-hydroxyoctadecanoyl-CoA and 16-hydroxyhexadecanoyl-CoA). Required for pollen development and sporopollenin biosynthesis, the major constituent of exine in the outer pollen wall. In vitro, can use 4-coumaroyl-coenzyme A as substrate to produce bis-noryangonin and fatty acyl-coenzyme A as substrate to produce medium-chain alkyl pyrones. May play a role in both the synthesis of pollen fatty acids and phenolics found in exine.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:21193570, ECO:0000269|PubMed:23632852}.
Interaction partners:
- Putative acyl-activating enzyme 19
- 4-coumarate--CoA ligase-like 1
- Cytochrome P450 704B1
- Tetraketide alpha-pyrone reductase 1
- Cytochrome P450 703A2
- Tetraketide alpha-pyrone reductase 2
- ABC transporter G family member 26
- Short-chain dehydrogenase reductase ATA1
- holo-[acyl-carrier-protein] synthase
- holo-[acyl-carrier-protein] synthase
Sequence:
MGSIDAAVLGSEKKSNPGKATILALGKAFPHQLVMQEYLVDGYFKTTKCDDPELKQKLTRLCKTTTVKTRYVVMSEEILKKYPELAIEGGSTVTQRLDICNDAVTEMAVEASRACIKNWGRSISDITHVVYVSSSEARLPGGDLYLAKGLGLSPDTHRVLLYFVGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSVDRPYDLVGVALFGDGAGAMIIGSDPDPICEKPLFELHTAIQNFLPETEKTIDGRLTEQGINFKLSRELPQIIEDNVENFCKKLIGKAGLAHKNYNQMFWAVHPGGPAILNRIEKRLNLSPEKLSPSRRALMDYGNASSNSIVYVLEYMLEESKKVRNMNEEENEWGLILAFGPGVTFEGIIARNLDV
Protein: Replication factor C subunit 4 (Activator 1 subunit 4) (Q99J62)
Organism: Mus musculus (Mouse)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication factor C subunit 3
- Replication factor C subunit 5
- Proliferating cell nuclear antigen
- Replication factor C subunit 2
- Cell cycle checkpoint protein RAD17
- Replication factor C subunit 1
- ATPase family AAA domain-containing protein 5
- Chromosome transmission fidelity protein 18 homolog
- Sister chromatid cohesion protein DCC1
- DNA primase small subunit
Sequence:
MQAFLKGTSVSAKAQLTKDRGTPATAGSSGETKKVKPVPWVEKYRPKCVDEVAFQDEVVAVLRKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQERLLDIAEKENVKIGNEEIAYLVKISEGDLRKAITFLQSATRLTGGKEVSEDVITDIAGVIPAATIDGIFTACHSGSFDKLEAVVKNLIDEGHAATQLVNQLHDAIIENENLSDKHKSIITEKLAEVDKCLADGADEHLQLMSLCATVMQQLTQNC
Protein: Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] (P55211)
Organism: Homo sapiens (Human)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Interaction partners:
- Caspase-3
- E3 ubiquitin-protein ligase XIAP
- Baculoviral IAP repeat-containing protein 2
- Cytochrome c
- Apoptotic protease-activating factor 1
- Baculoviral IAP repeat-containing protein 7
- Baculoviral IAP repeat-containing protein 3
- Bcl-2-like protein 1
- Poly [ADP-ribose] polymerase 1
- RAC-alpha serine/threonine-protein kinase
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Protein: Disintegrin and metalloproteinase domain-containing protein B (ADAM B) (EC 3.4.24.-) (Q4WQ08)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Probable zinc protease.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MRFLKSALPFVASALSLLSVQAAARSQEPSAIQHVSILEHAVINTPSHEVDHLTDFDVTFELPDKHQTIKLELEPNHDILADDAYVQYLDAEGNVHREEPIQRHEHKVFKGRSLLRRDNGLWRPVGWARVYVQRDGSKPLFEGVFSIDNDNHHVELKSTYLQKKRVEDASIPDRKDEYMVVYRDSDMIRQVRSELKRSLISSSSCQAEKLGFNSDPQHPIFRSEFQDMDLGMSSYGSMSLNSLFGLSKRQSDIGGVSGNAGGVNLAQTIGSTSGCPKTKQVALVGIAADCSFRASFDNDDAAKQWIINMVNSASDVYEKSFNISIGLRNLTMTDKTCPETAPASTQWNMPCDQSNITQRLNLFSQWRGQQSDDNAYWTLMSNCPTGSEVGLAWLGQLCNTEVTGDGSNSVSGTNVVVRVSGGGWQVFAHESGHTFGAVHDCDSMTCAQNLEASSQCCPYNRGTCDANGKYIMNPSTGADITAFSPCTIGNICSALGRNSVKSSCLSDNRNVVTYTGSQCGNGIVEAGEDCDCGGESSCGDNPCCDAKTCKFKSGAVCDDANDSCCSQCQFSPAGTVCRASLGECDLQETCTGNSSTCPADSFKKDGEKCGDTSGLTCASGQCTSRDYQCRTVMGSLIHDNNTYACPQFDSSCELICTSPSLGSCFSINQNFLDGTPCGSGGYCHNGRCDGSNFGSWVEQHKNLVIGVACGVGGLLVLSILWCMINRCRRARTVVKRPPMRPWPGPMPPPPPQMGQWAGPNRGYQGLRAEPPPPYPGPYQSATRYA
Protein: Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane-cleaving protease PARL) [Cleaved into: P-beta (Pbeta)] (Q5XJY4)
Organism: Mus musculus (Mouse)
Function: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16839884}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H300}.; SUBCELLULAR LOCATION: [P-beta]: Nucleus {ECO:0000250|UniProtKB:Q9H300}. Note=Translocated into the nucleus by an unknown mechanism (By similarity). {ECO:0000250|UniProtKB:Q9H300}.
Interaction partners:
- Stomatin-like protein 2, mitochondrial
- Serine/threonine-protein kinase PINK1, mitochondrial
- Prohibitin-2
- ATP-dependent zinc metalloprotease YME1L1
- Dynamin-like GTPase OPA1, mitochondrial
- E3 ubiquitin-protein ligase parkin
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- Mitofusin-2
- Metalloendopeptidase OMA1, mitochondrial
- Mitofusin-1
Sequence:
MALQGWVQRGWRCGPAWAPPLGGGYRELSATQAPRLLGRRFNLFVQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPIRTLVKPFFFTIGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
Protein: Small ribosomal subunit protein RACK1 (H0YAM7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQEYITTTYKLAVEMRAVSYSLPGVVAHAYWRLRWEDLLNCRGLRL
Protein: Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Q6AY65)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:P53365}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P53365}.
Interaction partners:
- ADP-ribosylation factor-like protein 1
- ADP-ribosylation factor 6
Sequence:
MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) (Q8TDH9)
Organism: Homo sapiens (Human)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Dysbindin
- SNARE-associated protein Snapin
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- BLOC-2 complex member HPS3
- Breast carcinoma-amplified sequence 4
- BLOC-2 complex member HPS5
Sequence:
MSGGGTETPVGCEAAPGGGSKKRDSLGTAGSAHLIIKDLGEIHSRLLDHRPVIQGETRYFVKEFEEKRGLREMRVLENLKNMIHETNEHTLPKCRDTMRDSLSQVLQRLQAANDSVCRLQQREQERKKIHSDHLVASEKQHMLQWDNFMKEQPNKRAEVDEEHRKAMERLKEQYAEMEKDLAKFSTF
Protein: Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) (O14978)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.
Subcellular location: Nucleus {ECO:0000269|PubMed:32051553}.
Interaction partners:
- Transcription intermediary factor 1-beta
Sequence:
MASGPGSQEREGLLIVKLEEDCAWSQELPPPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQRELGRLRQQVTNHGRGTEVLLEEPLPLETARESPSFKLEPMETERSPGPRLQELLGPSPQRDPQAVKERALSAPWLSLFPPEGNMEDKEMTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDSLESHIPSQEVPGTQVGQGGKLWDPSVQSCKEGLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLLPDQARGEVPWSPELGRPHDRSQGDWAPPPEGGMEQALAGASSGRELGRPKELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVDCTEIFGGNPRFLSLHRAHLGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNICGKCFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCPECGKSFSRSSHLVIHERTHERERLYPFSECGEAVSDSTPFLTNHGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTHTGEKPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLMSHQRTHTG
Protein: Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) (P06912)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:3838985}.
Interaction partners:
- Transthyretin
- 5-hydroxyisourate hydrolase
- Receptor for retinol uptake STRA6
Sequence:
MEWVWALVLLAALGSGRGERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFAVQYSCRLLNFDGTCADSYSFVFSRDPHGLPPDVQKLVRQRQEELCLSRQYRLIVHNGYCDDKSVRNLL
Protein: Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) (P40938)
Organism: Homo sapiens (Human)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication factor C subunit 2
- Replication factor C subunit 4
- Replication factor C subunit 5
- Replication factor C subunit 1
- Sister chromatid cohesion protein DCC1
- Proliferating cell nuclear antigen
- Chromosome transmission fidelity protein 18 homolog
- Cell cycle checkpoint protein RAD17
- Chromosome transmission fidelity protein 8 homolog
- ATPase family AAA domain-containing protein 5
Sequence:
MSLWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEACRVQQYPFTADQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMMF
Protein: Zgc:112175 (Q567B4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MAASTRLGPKVLLLVHLGVFSWYLFTIWSNCSLQTADRHPGLRSYGGRWKYLTFINLVMHAVFFGLCVLVDAVHSAVSVKQSRSGTPLNLSRARDFYFTVLAFPVGTFVFVSFWTLYTYDRELVYPKLLDEIIPIWLNHAMHTVIMPLLLLQMFLQNHRYPSRTAGIFSLAVFVALYLSWVLWVHHASGIWVYPIMAHLSPVGLCVFLGGASLSMAPLYLLGEKLSLMMWSSTGNQKKKKK
Protein: DNA replication complex GINS protein PSF1 (Partner of Sld five 1) (Q12488)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for DNA replication. Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery. Required for the chromatin binding of CDC45.
Subcellular location: Nucleus {ECO:0000269|PubMed:12730134}. Note=Associates with autonomously replicating sequence (ARS) regions in S phase. This association requires SLD3 and DPB11.
Interaction partners:
- DNA replication complex GINS protein PSF2
- DNA polymerase alpha-binding protein
- DNA replication licensing factor MCM4
- Chromosome segregation in meiosis protein 3
- Cell division control protein 45
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM6
- Minichromosome maintenance protein 5
- DNA replication licensing factor MCM3
- DNA polymerase epsilon subunit B
Sequence:
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQLGMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDTNNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI
Protein: Transcription factor CSR2 (CHS5 SPA2 rescue protein 2) (Q12734)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12444972}. Nucleus {ECO:0000269|PubMed:12444972}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Protein ROG3
- Protein ROD1
- Protein LDB19
- pH-response regulator protein palF/RIM8
- Arrestin-related trafficking adapter 10
- High-affinity hexose transporter HXT6
- Arrestin-related trafficking adapter 5
- Carboxylic acid transporter protein homolog
- Chitin deacetylase 1
Sequence:
MQSTVPIAIASNGNKRDVVQNVSAGDEGDILQRLARNREMISTSLSPQKSSGFSGRRRSSSVRDALSSFFGTGNSPTSSMDDYSNLMNRNYSTASTAMCRGNSFPSDVGTKAYNITGSYQPDRHRNSVPYTTIDQLHTRQDTGLRRESDPVAAKQISSNNDIVRSFITHHASNSTMFINRVLSDYLADRGFIKQTPLYNKKSVLEISIATSAESVFLPTTKSDETEYLSLIHGSLNQARTQPVGSTNTAESDFLPSCPTMDTLNENNDLSLFPLHTQRTSPSNTARTGNAMDTSNSDRASPASNNNTTDADSFVASGNNNPMNNNNSPARNRHPNSHSRSLPNAWNSQMPSFSFALIFSLNKSTTLSDIKVELTSNVRVVWFNGLPPTKNVNEECYNIGSLDWTLNADNFNLFIPQGAKSPLDIVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNKLNAGVYVFTIPIVLASRIPESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSISSPQKLRSYSCSDSYEYSQIDDTIEGETYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAMQHDSEDTINLQYPLNLVRTPPEISVTTANKPLYINKVWENCLSYEISFAQKYVPLNGEIPITIKVAPLVKSLSVKRIRVSCREKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVRKKKDRSLPLFEVASKCTSGPSIREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFPKYCEVDATKAASLPPYGIDLFDPIKDPTQSENTSNNGNVLGFLVGRPNRASKTVHKIPQDKNHNEVNDTNGNSNTSLQTSSNVPIQHYTRLNKPRRGLYLDSMHFKNIQCSHKLEIVLRVSKTDSGSSKIIRHYEVIVDTPIYLISDLCNTSNIDLPTYDMATTESSKVLPPTFEEATSVSASPRSSVSYYPDDISMQQLNLSRSTSLANGYLSTLHPKTTAVSDSSNGAPIRDQQEQQARPLRTEDYALQMGNENNAYSNMDGLLSQDIFEQETAATLFKRDIVTMNFNNNIFTPRYSPRTFTNTDYNYNDNDNNDNDTEGPGPIIHPGPEPPRYDEISS
Protein: Actin-like protein 7B (Actin-like-7-beta) (Q9Y614)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Alpha-catulin
- Dynactin subunit 2
- Actin-related protein 10
Sequence:
MATRNSPMPLGTAQGDPGEAGTRPGPDASLRDTGAATQLKMKPRKVHKIKAVIIDLGSQYCKCGYAGEPRPTYFISSTVGKRCPEAADAGDTRKWTLVGHELLNTEAPLKLVNPLKHGIVVDWDCVQDIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLNEAGHAFTDDHLHIIEHIKKKCCYAAFLPEEELGLVPEELRVDYELPDGKLITIGQERFRCSEMLFQPSLAGSTQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPAVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSVAIYSKC
Protein: Ammonium transporter (Q9VFA9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362002}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Rh50, isoform B
- Glutamate synthase
- Glutamine synthetase 1, mitochondrial
- Glutamine synthetase 2 cytoplasmic
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MNNGTVGAPRNHSNYVIPGLYDLSVEDTNWVLTSSFIIFTMQTGFGMLESGCVSIKNEVNIMMKNVIDIVLGGFTYWLFGYGMSFGRGPLSNPFIAIGDFLLDPPVGDALMGQIFAAFLFQLSFATTATTIVSGAMAERCNFKAYCLFSFLNTAVYCIPAGWVWGEHGFLNKLGAVDIAGSGPVHLIGGASAFASAAMLGPRLGRYSEGYDPLPLGNPVNACMGLFVLWWGWLAFNSGSTYGVSGAKWQYAARAAVMTMMGSFGGGFTSSIYSFWRHGGGMDIMDLINGVLGSLVSITAGCFLYRAWEALVIGAIGSLFCVLAMPLFDRMGVDDPVGASAVHGVCGIWGVIAVGLFADNPIPLDTTNGRSGLFKGGGWYLLGIQTLSALCLACWGVCSTFLLLYVINKIIPIRMDPHEELLGADLTEHRIRHSQIGLSRAISALAPIKVDLKDIAGIQPIGINPGHERSIDQLRAAEDKLQQWQSYLEQVSGSRANVKMDAGQSHADINFKPRTAGNVFNRRIPARKSISGGLYRSNNSELPVIGSVMGQKPEKDPNFAWVD
Protein: Uncharacterized protein (Q382M5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- uracil phosphoribosyltransferase
- Glycogen synthase kinase-3 alpha, putative
- Glycogen synthase kinase 3
Sequence:
MYSSWQQRHQQGGKNNHNRKHPSAQNIINGSITFGEETKNVDMTEVPVPKVTVGLAGGEQKRAQPHGPTKSFDTISDLRSHVISLVQSGRLPGDSLEVLKVMLRHPPRGGKLDICRPARQEKPFSVNTPSVQRANVAQRKNRDQLSQELCSMGTAFFGYPQPPLFGGPAGMFSTYGGYQTHMGQEHSNLDGFNLCAIPGTDGVYPTGSGPDPFIFGDQQEQAPWMYDLEGDAFACYDAFVPMYGVVGQDAVWGLKNDVDTSDDGDDVTGMLHDVREAAQIGLTPRELRLGGFDGDGNLPFPFAGAAYGAQEPNNSSISNATSTPVPSVTISHSEREKLRSLQQAFLAHVRQTSSPHCKSPGVSPPGTWCALVGGNGPWGARTQDGSQDVGEEEEDSFWYPPNRTLFSYHTDFSEAMDDKGAPGSTVCGVTAKAIASMTNSPRGGRGPDGLLRDAHLSTIFLGTEGETAEELLYQWTPVDDGSKMGPSDEATPTCVPSARFCETAGSGVAAGLSASNFCATLSPVQVTLQKGQAVGYLHLPLTPAGSGLSTHASLSPTGVTPVGSEEVNATPKLSDCVRHHRSSFTPQDLSVSAAYFI
Protein: Phosphotransferase (EC 2.7.1.-) (Q7JYW9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glucose-6-phosphate isomerase
- Phosphoglucomutase 1
- ATP-dependent 6-phosphofructokinase
- Fructose-1,6-bisphosphatase isozyme 2
- mannose-6-phosphate isomerase
- Probable glucosamine 6-phosphate N-acetyltransferase
- Glucosamine-6-phosphate deaminase
- Sorbitol dehydrogenase
- FI19814p1
- 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase long form)
Sequence:
MLDAEVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVASKTK
Protein: Autophagy protein 5 (A9UGY9)
Organism: Homo sapiens (Human)
Subcellular location: Preautophagosomal structure membrane {ECO:0000256|ARBA:ARBA00004623, ECO:0000256|RuleBase:RU361202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004623, ECO:0000256|RuleBase:RU361202}.
Interaction partners:
Sequence:
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLKEVCPSAIDPEDGEKKNQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIIPQPTD
Protein: Mitochondrial pyruvate carrier 1 (Brain protein 44-like protein) (P63030)
Organism: Mus musculus (Mouse)
Function: Mediates the uptake of pyruvate into mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:22628554}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial pyruvate carrier 2
Sequence:
MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDMKKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHVTNEVAQLIQGGRLINYEMSKRPSA
Protein: Uncharacterized protein Rv2901c (P9WL27)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Ribonuclease HII
- Signal peptidase I
- Transcriptional regulator WhiB1
- Transcriptional regulator WhiB2
- Large ribosomal subunit protein bL19
- DNA-directed RNA polymerase subunit omega
- Probable protein-export membrane protein SecG
- Uncharacterized HTH-type transcriptional regulator Rv1830
- Transcriptional regulator WhiB4
Sequence:
MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSVEMVPRNTDGEVYFELRLADAWVWDMYRPARFVKQVRVVTFKDVNIEEVEKPELRLPE