wanglab/gogpt-training-data huggingface dataset:
Protein: Neurexin 2a (Neurexin-2-beta isoform X18) (B7ZCV1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Neuroligin 1
- Neuroligin 3b
- Neuroligin 3a
- Neuroligin 4 X-linked b
- Neuroligin 4 X-linked a.
- Neuroligin 2a.
- Neuroligin 2b
- Neurexin-3a.
- Neurexin 2.
- Leucine-rich repeat transmembrane neuronal 2
Sequence:
MYSFQRMGQMGCGRAYAGPSCPKLEVVLLGWECGGGGSWLGLGSWWRLALSLALLASVPDRSASARVSSSLSTTHHVHHFHNKHGTVPIAINRMPFLTRGGHAGTTYIFGRGGALITYTWAPNDRPSTRADRLAVGFSTQQSDAILVQVESSQGLGDYLQLHIEQGKVGVIFNVGTDDITIDEPAVTVNDGKYHVVRFTRSGGNATLQVDNQPVIERFPSGNIDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKVGGQDKGRPFQGQISGLYYNGLQVLKLAAEGDPNVQVAGNLRLVGDAPSVLSTETTSATPPAAADMSTTIMETTTTMATTTTRRQRSPSLKDSITQNSDDLLVASAECPSDDEDLEECEPGTGGELVLPIITVDTQDPISMATRYPAIPAPPTSLTPLQTTKESLILSDPRPPCPPDQEDCGDPMEVSAFGSGEMTESDDEDFNRNSPMVTDRTVLPPPPGVGKSGHGDHRPPVPAPTTHPNQLHIPAGKMNTRDQVLLPPVPSSRHTPGLTYPPDFPHVPTAHPTDLMEKGRPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNSGSESNGAVVKEKTPSTTAAVAKTTTKGKKNKDKEYYV
Protein: Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) (B5DFF7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQEFNLSAYFERAADFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMLRQKMDVRSALSTVRQNREIGPNDGFLAQLCQLNDRLAEEGKVKL
Protein: At1g17940 (Endosomal targeting BRO1-like domain-containing protein) (F2H15.16) (Q9LMT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Endosomal targeting BRO1-like domain-containing protein
- Serine protease SPPA, chloroplastic
- Vacuolar-sorting protein BRO1
- Protein FREE1
- Protein ELC-like
Sequence:
MGCFASTPKDSGGNRRKPTSIGEVSVYVPGLRIPRAVDFLQSLGDQLPKTLVERLTALRTRIVVMANQEGPTITRTRRKTQHGGSTLLDLHQALLDYLPVVLGLTKDGSHLQFKVQFNWVNQEDEEEETEMSNVWYEVLSVLHLMAMLQMSQANLLLLPRGSSDGHNHPKVSEENRRTSIDIFLKAAGYLDCAVKHVLPQFSAEQRRSLPVDLAEGTLRALCLQALGQGVDIQLGMAIDSSKATLAVKRRLSCEMVKYWQQAQDNLMNLPLANGWGEKHGLFVKWKYVEAKAAAYYYHGLILDEGNTEKSHGMAVAALQAADECFKESKKASEAFNASAPTSRTPPLFGTMKYLTEKIPKDTSSKVRINRDLYSYEKIMETAPTLPDFALALKPDEYQLPLAEAS
Protein: Tln1 protein (Q3B7U7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
ELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHFGRECANGYLELLDHVLLTLQKPNPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH
Protein: RRM domain-containing protein (Q583Z2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- C2H2-type domain-containing protein
- Leucine-rich repeat protein
- Anaphase-promoting complex subunit 4 WD40 domain-containing protein
- Uncharacterized protein
Sequence:
MWNAFSGFQPPKLRDGNGGWGSGRPYRPMRVGGQPYHKERFGAPSYPQTQGGYQHHGNLDPMNRSYSRHTPQAAHRIRQPNIDEPFAWKAFMRRSTEGAIYRGTTQLEGSQRTKESGETTSPNGLARHIDGEAWNAYWGEYSDHFASRIDDVQEHLSKGERYNGKRCVRVATPIPKDSLMESFKSRMIDYARHFGAIECVTRDGGVVGVQFTTHRSAELFAVWAASMTFVEILGDTVKPDEVNGPVEMVVRLAPHDPNRLTTTLRLGDNIVLSTAFVEGLFKGIFDAEDIKFHAGAFQITFGSVQAAKVALHSVQRHLFDGFGLLLTFSEVPLGAGPLMPHAK
Protein: Carboxypeptidase B (EC 3.4.17.2) (Q6NWD1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}. Zymogen granule lumen {ECO:0000256|ARBA:ARBA00037795}.
Interaction partners:
Sequence:
LFLLLGLVAVALCEPITFVGDKVLQLKPINDEHVTIIRELGEKIKLDFWKPRSADLVSIDMTVDIHVPAAQLAMVSTILQQSDMEVKVMIDNLQEAVKGQMDNRSPTKGHDYTKYNSWATINDWAISISSANPDLISRQSIGNTYEGRTMHLLKIGKNTGSNKPAVFMDCGFHAREWITHAFCQWFVNEAVSTYGSDPDMTNLLDRMDFFVLPVFNIDGYEYTWNRDRMWRKTRSKNSGSSCIGTDPNRNFNAGWCTVGASSNPCSDTYCGSSPESEIESKNLANFIRTNKSVIKAYLTVHSYSQLLLFPYSYKYDLAAHHSELMSVSQGAIAALRSLYGTKYTSGPGAATIYPAAGGSDDWAYDLGVKYSYTFELRDEGRYGFLLPESQIKPTCEETMLAVKYIANHVLNNLY
Protein: tRNAHis guanylyltransferase catalytic domain-containing protein (Q86IE7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
METKDKKKDMELLGDRMKSYEDDMKIQIEKNKPFIIRLDGHSFSKFTKNFNKPHDIRIHNAMIETSTVLLKTFMPTCIYTFSDEITMCFPSIDESTLEEGKEIPNLAYSGKVQKLISLSSGLASTVFFKSITNAQYDKDTELNLIKLLETCTPHFDARIFTLPSNQEIVNNLIWRSLVDCKRNSVANLGFAHFTPKQMLGLNNTEVKKKLLEEKSIIYENEPAWYRFGTYLKKEYYTLTTVSPNEPEKQITAIRSKVNCFSFDITKLSNSLNFISFKTLPEGFNLELIESK
Protein: Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) (Q9H0H5)
Organism: Homo sapiens (Human)
Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. {ECO:0000250}.
Interaction partners:
- Kinesin-like protein KIF23
- Protein ECT2
- Kinesin-like protein KIF20A
- Anillin
- Cell division control protein 42 homolog
- Transforming protein RhoA
- Kinesin-like protein KIF11
- Protein regulator of cytokinesis 1
- Aurora kinase B
- SHC SH2 domain-binding protein 1
Sequence:
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKREKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVPYWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHLQRVAQSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLLSLPLEYWSQFMMVEQENIDPLHVIENSNAFSTPQTPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRSTLTKNTPRFGSKSKSATNLGRQGNFFASPMLK
Protein: Adenylyl cyclase beta (EC 4.6.1.1) (C0H4R1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Thioredoxin-like protein
Sequence:
MLKNIFSEYLKSYDNKDENYERINNLSRNYSCDYTSDWRWFSIKCERFLENELYKKYNKEEREKKKKNKNIIKENENLAIFRSFFPKILLNIYSKCENPAQFFSNLVIQKFNSVVFFCDASGFSNLAEQLDKRINGTELLGNCLNKFFNILIKIIDYWGGDIIKFSGDAVLVIWPLHNVLKNKKKKKKKNGTQNNDSDDEHVNLKDNKTSHDRYNLDKHIDMEKHKTNFENFNLSNNHNNIHNIYNNDDDDYGDHQNEVYDNIKNYNLKNNKISKSNIAQANNSDDNYPSDYNKKKKNQNAVEIRKICLLALGCCMDIHKLLNKFPTPIENKYLKVHIAITYGKVSFLQIGNVLRKREYLLSGKPLEEIGAGESLAKNGESVLSYSFYKNIKDKVMVQGTCKKNFFLFVKMKEEIDMKKLKKNYEEEEEEQQQNEREEQNEREEQNEREEQNEREEQNEREEQNEREEQNEREEQNEREEQNKTEEQNKTEEQNKTEEQNKTEEQNKTEEQNKTEEQNKEGQLPNLLVDNRSVVKEEENISKNNIKDNKRRNSLEDKIKKRFTLLSTDKQSRQSTIIYENFDLLLKTFIPDIVYRKLSLGCNIFFNEIRKVTIIFVSVKDIDASTMTGVHSAHGIMKLTQKAVFTMEGTINKFILDDKGILILIMFGLPPLYHCDDTIRALLTCFRLIDALKSLKLNGSIGISTGKIWCGIIGNKIRKEYTALGDSVNVAARLCFKAGNKEIYVDENTYNNCKHFISFQKLISIKVKGKNKLIKIYSPIGTINKKSIDYVYDNTSNDNNYFTDEELLVNNQNNKKNNNILLNKEETIKNVHENLYTNIDLSIIQNKLIKTNYQQIFDFSFLNNNFLFIYYKSFFKNKIYHLFKEKNSFYYLQNLDTNNYKIITTTTFPNYSLNKNIEQINNNHLIIKKDMDKQYVNNHQNLNHTIKQNQFILHKDGNHINSYDDFHGKSHSPSKSFSSINNTYNNLLTYDMIYSLSRFNKIKTSLHVDYKSYTGPFLLHEYYDPFHFKFKELSRIGGVLFVEGNENLGIFEFIKLITNGLYNFKLFNVSNMPNSLYINITNPLLPWKILCNDILNTWKLSHMRKKNLLLNKNDNFNMLREITHPSYHWFFKSMIHVIDDLDIPFFKTKKKKKKKEKEKEKEYYNHKHKNYSYQTNKYIHNHTNKKNEHNLIQNKINTNTQTQNASNNSNNNIFCQKISTFLEYFFHNSRREKKKNKKKSKEKIKKKKKTLQDGKHIGNTNDMDAIYNGPSDVSHGSTWDKQCNNDDDDDDIHDDNHDDNHDDDDIHDDNHDDDDIHDDNHDGDDIHDDNHDGDDIHDDFHDDDDIHDDIHHDDNIHDDDNYNTPVRKHNVKKNKLTNKHEPSYPKHTATGDVSSSSHAYSRNDIQTKMKNELKENRIGIISSMIYYFTLHENMFIIFNYRSGTSLNINIEDDAWKISNNIAKLAMLKRKKISKHLQKNLKDWRKNHSRKCDFCKGNFMNTTYVNNVHENNKCADNIYGNITNLNNIYGDNTNDSFLHNNDDDDNMYNSDKQNRLSFKKNINDFLDDHMRAQSIDHVDKNIISQIHNDINNDTNTNNIYNINDMYNEENSHYSQNINITNDNNNNNNKKNSSSSNNNNNNNDISAFSLKQQKLYQAHEIILMDENNDSSSKKSSSATLINNSEINSQIYNNENIIHNTNKQENINVLQLFKEEKDIVNNTNKIKEQKMFYKTLCPNIKDNILLYIAQQKMNEQNNNYQMNKNQNSKNNYLNDNIQNQINHLVKDNMDKHIYNNNNNNNNDNVYQNKSPLCNPFFMHKHKPLIFLFINGMKNNSNIKQLKKIKKYAQQCEASIELKPFNKYDLYEFVSLCLNIHKDKISTQLIEYLNKTCFGIPKFVQYTLFYLLTNHYIELYKYEKDKNDKHNYENNDELHPSVDARKNNEKNNEKNNEKNNEKNNEKNNEQNNEKNNEQNNEKNNEQNNEKNNEKNNEQKNEQKNQQKNQQNNEQTNQQNNQHNNDEIFFLKEQKYEKDSSSTNPAKINHPNDITCANQFNQINNINQNYDKNNYINHFSKQIISVQNETVKSSVFPSNSTTSCNDNSNNDDINYEYDLVVVKDLNEAPLVPRLTAYCMSLIDSLNQEEQLLAKLCSFFNNTFNIKKMECIYPKYISRCELKKIIVKLVEKNVFCLYEDPNKKSVTLPKDNVNSIHNINFVYRDMYNKINSFLEKKSKHHSLFGKHKNVPDEEIYFCITNFSLKKVLNDLLENEEKEYIKKIYKKYIES
Protein: Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra) (P05112)
Organism: Homo sapiens (Human)
Function: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.
Subcellular location: Secreted.
Interaction partners:
- Cytokine receptor common subunit gamma
- Interleukin-4 receptor subunit alpha
- Interleukin-2
- Interleukin-13 receptor subunit alpha-1
- Tyrosine-protein kinase JAK3
- Interleukin-1 beta
- Interleukin-7
- Interleukin-8
- Tyrosine-protein kinase JAK1
- Signal transducer and activator of transcription 6
Sequence:
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Protein: B-cell lymphoma 3 protein homolog (BCL3 transcription coactivator) (E7FFI8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit isoform X1
- Ubiquitin carboxyl-terminal hydrolase CYLD
- Ubiquitin carboxyl-terminal hydrolase CYLD
Sequence:
MTMSDSNHIARSGSPLDLTNKRGICAQTGDQRPPRQTQETQVRSAHKFKGHGVHPKESRDTCDGSVSKTTQTDDVGDRGNRTRGGPTQTRPVTPSSKCNSQTDAAGKDSSFSKLPIRKRPFPVDVDHDTSVSHNQSPKVLIPEETHRDADARLIFNTSCPPYRYPCISWPQHYGSPQKPMHMPVPTFSPPSLLESKERLLADIAAATRQDEDGDTPLHIAVVQENRALVVWLIEIFRCAHKDLDIYNNLRQTPLHLAVITHQPAVVKALLDAGSDPGALDRNGQTAQHLCCEHGEAECLSIILRHYSHNNPSHVEIRNYEGLTPLHLAVQNGDQTLTGILLDSGAEINAGDNKSGRSPLVHAVENKSLDMVLLLIERGCDVNAQSYSGNTALHSACGRGHIEMVRVLLKNGADSSLKNNHNDTAIMVAKNKKVSDVLRGKGTRSFTGKTISSSNGSLSPSSSSHSPRMTPTFQGSASHSPVTPVLPRSQSVESISERHSPLNSNDKALFQMQTLHSSPVDNRAGYGFHNLAYLSPSRYDHIKPAVHRRTLIASPYYYGPGFPRPPYYSDAPFILVPSLPLQAAFISPQGTINQSRPSSHSSDQSDISTVSVNSEERGVS
Protein: Receptor-type guanylate cyclase gcy-23 (EC 4.6.1.2) (G5EEE9)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:16415369}. Note=Localizes exclusively to the sensory ending, known as cilium, in AFD neurons. {ECO:0000269|PubMed:16415369}.
Interaction partners:
- Probable 3',5'-cyclic phosphodiesterase pde-2
- Bis
- Inosine triphosphate pyrophosphatase
- Cyclic nucleotide-gated channel
- Cyclic nucleotide-binding domain-containing protein
- Probable 3',5'-cyclic phosphodiesterase pde-5
- GTP cyclohydrolase 1
- Probable 3',5'-cyclic phosphodiesterase pde-1
- Probable 3',5'-cyclic phosphodiesterase pde-3
- Phosphodiesterase delta-like protein
Sequence:
MRRELFIFLLLLGECANVKVKVGHIGAVGSMRNAEKILQLSKEQLTQEGVLGNDFDIEILNQMGCGESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVAKMATFWNIPVVGYMASSNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVAIATNTGAVAFERVQSFEEVFHQRGINVVRKIMLEEYTNAKAIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMNNANYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDNTLVTPFKERLEASGYSTDDLEMKNIYGYIHLYDALRLYALAVRATMNETGNENSYLNGKEVWNHMRRITFPGLVSNAGVTSGTVMMDDIAERAPVYAAFYVPPNSDTVRKVCELEPVMLTNCDGTKTGNGCYELQVTDLSTGFWPSIDGSLPADEPACGFRNEKCDYTTLIIGGCIVLLIILLIICFFILSRVCENRALANTPWRIYRDDFRTIQENEMKSMLSIGSSKTKMSNMSMFVKHHAVVGTNTHASFHLYPQRRPIVFNRQDLQLLNQMKQAVHDNLNPFLGMSFNEKEEMVVLWKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLGLEYLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNTENYLKVKGSLVDQMMRMMEQYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSEFQITLRGTVEAKGKGPVTSYWLLGKQSESQMQQQNFSQLGI
Protein: Methyltransf_11 domain-containing protein (Q94259)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNNRAHPFLCPSRFYPILLIVGLFLMITILFLNDSNSVRSLKNSISRIKLPDPFPAVNLKEYKIKTYRGYVSMDELNENVFKKFGYEITRPTYPVPTVRMINEPTCEEVFFAWQKISEQPQPKFPPKTIPAERMNEFLLYNYTALSDWYINDKNSEKGEKPRNWENLSELIKWPRAKLGGLAYGSDGVSIYDAMHAYRLDGKSGVVIGSMQPWVEVSALQSGASKVLTVEYNKLTIQEEFRDRMSSILPIDFVKNWRDYAGTFDFAASFSSIEHSGLGRYGDPVDPLGDLREMLKIKCVLKPGGLLFIGFPLGTDSIQYNAHRIYGSIRLAMMMYGFEWLDTFSGDKEEANDLTSDRLHSKPIFGQIQNTLVLRKL
Protein: Uncharacterized protein C227.17c (Q9UTC2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MNNFKENDEKSTFGQYAELDKILDLKKGIPEDPCSLQYYFDQMAMCLTVFSQMNHYYRYGEYNRCKGNFKDFKWCLSTKSKAHEEAQEGLRKRRLQQWMKFRQGPNSEDIWKMRTSPKSSE
Protein: Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1) (Q8CD10)
Organism: Mus musculus (Mouse)
Function: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:23409044}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8IYU8}. Note=Recruited to the mitochondrial inner membrane via its association with the uniplex complex. {ECO:0000250|UniProtKB:Q8IYU8}.
Interaction partners:
- Calcium uniporter protein
- Calcium uptake protein 1, mitochondrial
- Essential MCU regulator, mitochondrial
- Mitochondrial calcium uniporter regulator 1
- Calcium uniporter regulatory subunit MCUb, mitochondrial
- Calcium uptake protein 3, mitochondrial
- Mitochondrial adenyl nucleotide antiporter SLC25A23
- Prohibitin-2
- Mitochondrial sodium/calcium exchanger protein
- Mitochondrial proton/calcium exchanger protein/H
Sequence:
MAAAAGRSAWLAAWGGRLRRGLAAGRRAVPTRGPLAAAVAGVALAGAGAAWHHGRVKAAAREGSRTVSAQKNYLGPIEKLSLRKQRFMQFSSLEHDGEYYMTPRDFLFSVMFEQVERKTLVKKLAKKDIEDVLSGIQTARCGSTFFRDLGDKGVISYTEYLFLLTILTKPHSGFHVAFKMLDVDGNEMIERKEFVKLQKIISKQDGFKTVKTNETEYQDPTVKEPGVNTTLQVRFFGKRGEKKLHYKEFRRFMENLQTEVQEMEFLQFSKGLNFMRKEDFAEWLLFFTNTENKDIYWRNVREKLSVGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSDNLLDTVFKIFDLDGDECLSHGEFLGVLKNRMHRGLWVSQQQSVQEYWKCVKKESIKGVKEAWRQQAGKGPF
Protein: Maternal effect embryo arrest 18 (F4IGV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEICYFGGLVHYKSPSLPLSLHSLFRSKKPHYYNSTSLMAECLSSSTVEPPSLLVFSGGTGFNGVVEELKKLTTRVAHVLPVSDDGGSTAEIVRVLGGPAVGDIRSRCLRLSDESTSEALAVRRLLGHRLPIDAHQAKKDWYDIVEGNHSLWDGVSRPYSETIRAFLIYFQNEIHRRPNERFCFSNGSIGNFFFAGARIFFQSLDAAIFLFSRVSEIPCDSLVLPVISTNDRLTLGCELQDGTIIRGQNEISHPTTGTTQTVDKRHCSTSALPSKIKRVFYMSSEGNNLLHEVFPPVNPTVLEQLRSVDCIVYAMGSLFTSICPSLVLLGVGEIISSRSCRKVLLLNGSQDRETSRFTASCFVTAIADALNRTHGDTNIRLKNPPGYYINTLLVPKDGEIAVDLKQLSEQGIYDVVSISFLHLFPSLCAQQTLTVTSTLLQRVVESVGDPKHGILFNPSSLINTLAGLVE
Protein: Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) (Q96JB3)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor.
Subcellular location: Nucleus.
Interaction partners:
- C-terminal-binding protein 1
- C-terminal-binding protein 2
Sequence:
MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS
Protein: Chaperonin GroEL (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin-60) (Cpn60) (P37282)
Organism: Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600}.
Interaction partners:
Sequence:
MSKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILKTNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAKATVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNATRAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATGQWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM
Protein: DNA-(apurinic or apyrimidinic site) endonuclease, chloroplastic (EC 3.1.11.2) (Apurinic endonuclease-redox protein) (P45951)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Repairs oxidative DNA damages, seems also to act as a redox factor. Is multifunctional and may be involved both in DNA repair and in the regulation of transcription. Exhibits apurinic/apyrimidinic (AP) endonuclease activity. Catalyzes the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH. May be involved in base excision repair in chloroplasts. According to a report, has a significant in vitro 3'-phosphatase activity. According to another report, has no in vitro 3'-phosphatase activity. Has a strong non-specific affinity to DNA.
Subcellular location: Plastid, chloroplast stroma, chloroplast nucleoid {ECO:0000269|PubMed:19372224}.
Interaction partners:
- Polynucleotide 3'-phosphatase ZDP
- N-glycosylase/DNA lyase OGG1
- Adenine DNA glycosylase
- Endonuclease III homolog 1, chloroplastic
- Flap endonuclease 1
- Endonuclease III homolog 2, chloroplastic
- Transcription factor AS1
- DNA ligase 1
- Proliferating cellular nuclear antigen 1
- Proliferating cell nuclear antigen 2
Sequence:
MNNVLQFGLQSSAIYVAKFLVVPLRSLRVGSSFVGVGVGTRSFNKRLMSNATAFSINNSKRKELKIPGAAIDQNCHQMGSDTDRDEMGTLQDDRKEIEAMTVQELRSTLRKLGVPVKGRKQELISTLRLHMDSNLPDQKETSSSTRSDSVTIKRKISNREEPTEDECTNSEAYDIEHGEKRVKQSTEKNLKAKVSAKAIAKEQKSLMRTGKQQIQSKEETSSTISSELLKTEEIISSPSQSEPWTVLAHKKPQKDWKAYNPKTMRPPPLPEGTKCVKVMTWNVNGLRGLLKFESFSALQLAQRENFDILCLQETKLQVKDVEEIKKTLIDGYDHSFWSCSVSKLGYSGTAIISRIKPLSVRYGTGLSGHDTEGRIVTAEFDSFYLINTYVPNSGDGLKRLSYRIEEWDRTLSNHIKELEKSKPVVLTGDLNCAHEEIDIFNPAGNKRSAGFTIEERQSFGANLLDKGFVDTFRKQHPGVVGYTYWGYRHGGRKTNKGWRLDYFLVSQSIAANVHDSYILPDINGSDHCPIGLILKL
Protein: Sap30p (A0A1D8PG34)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Asg7p
- ATP-binding cassette alpha-factor transporter
- Plasma membrane fusion protein PRM1
Sequence:
MLFTILSLLVPSLAVAVSNTGGAVKLDLTISDEHMYYIENLALGTPPQFISNVIVDSGSSDLMIVDSIYNFSASSSLYNSNQTAIMKYGYGGQFPVYFINETIRSNDWKLSNLSVGLANISDMDSFSGILGIGFTRQELFKTNYSNFPYLLKDQGYTKSVLFSFNGQDQNPSIIFGGISTNIIDGPLVRAPFIKVISFINQLDYWLMPTFTVNQIKLGDTIVSNQKTLYQIDSGTNGFVPPTPVLNNILKILGDDYIQDDNGNIYFDIKYIEGLNITFSVQGYDIGFQLVDIVGDTIERNSTTFVALNVASCDIGYNAYEGLLPNLIFKYHYAIFDYDNAQIYFGKYKNSNGEANVVAVENGYQLPVPTVDVPDVEDTYSVIYIAESETTVTVAPTEVQSTYSSFSISEGTSSNLTSGSTSDDKITSVTSNPQYC
Protein: MICOS complex subunit MIC10 (A0A087WU07)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU363011}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU363011}.
Interaction partners:
Sequence:
MSESELGRKWDRCLADAVVKIGRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ
Protein: Lupeol synthase (BgLUS) (EC 5.4.99.41) (A8CDT3)
Organism: Bruguiera gymnorhiza (Burma mangrove) (Rhizophora gymnorhiza)
Function: Oxidosqualene cyclase involved in the biosynthesis of lupeol.
Interaction partners:
Sequence:
MWRLKIAEGGNNPYIYSTNNFVGRQTWEFDPEAGTPEERAQVEEARENFWRDRFLIKPSSDLLWRFQFLSEKKFKQRIPQVKVQDGEEITREIATTALRRSVHLVSALQASDGHWCAENSGPMFFVPPMVFSLYITGHLNAVFSAEHCKEILRYIYCHPNEDGGWGLHIEGHSAMFSTVLNYNWLGKLGEGRDGGKDNACERARRRILDHGSATAISSWGKTWLAILGVYEWDGCNPMPPEFWAFPTFFPIHPARMLCYCRLTYMAMSYLYGKKFVGPITPLILQLREEIYNEPYDQINWSRMRHLCAKEDNYYAHTLTQIILWDAIYMLGEPLLKRWPFNKLREKALKITMDHIHYEDENSQYITIGSVEKPLLMLACWHEDPNGDAFKKHLARIPDYVWLGEDGIKIQSFGSQVWDTSFVLQALIASNLPSETGPTLEKGHNFIKNSQVTQNPSGDFRRMFRHISKGSWTFSDKDHGWQVSDCTAESLKCCLLFSMMPPELVGEKMGPQRMYDAVNVIISLQSKNGGCSAWEPAGAGSWMEWLNPVEFLADLVIEHEYVECTSSSLQALVLFKKLYPEHRRKEIEIFILNAVRFTEEIQQPDGSWYGNWGICFLSGTWFGLKGLAAAGKTYYNCTAVRKGVEFLLQTQRDDGGWGESYLSCPKKIYVPLEGNRSNLVQTALAMMGLILGGQGERDPTPLHRAAKLLINSQTELGDFPQQELSGCFMRNCMLHYSEYRDIFPTWALAEYCKLFPLPSKND