wanglab/gogpt-training-data huggingface dataset:
Protein: Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Overlapping with the m-AAA protease 1 homolog) (Q9D8H7)
Organism: Mus musculus (Mouse)
Function: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (By similarity). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (By similarity). May also cleave UQCC3 in response to mitochondrial depolarization (By similarity). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:24550258, ECO:0000305|PubMed:20038678}; Single-pass membrane protein {ECO:0000305|PubMed:24550258}.
Interaction partners:
- Dynamin-like GTPase OPA1, mitochondrial
- ATP-dependent zinc metalloprotease YME1L1
- Sialoadhesin
- Mitochondrial inner membrane m-AAA protease component paraplegin
- Mitochondrial inner membrane m-AAA protease component AFG3L2
- Presenilin-associated rhomboid-like protein, mitochondrial
- Mitochondrial inner membrane m-AAA protease component AFG3L1
- DAP3-binding cell death enhancer 1
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- Mitochondrial inner membrane protease ATP23 homolog
Sequence:
MSLLYGLQSTRINRFLSGVNNLANRRQWTPPASCPLAPKLRAVNAYWGLNTVSHCHSVTLLPRNFLFCRTLNHKKSRCLSSAQSKELGVLTYRCTVRGDSVLRQGARKVAGVPALAASCSPSCPAVIEARSFRTSARVQAAPVPLLLLILKPVQKLLAIIVGRGIRKWWQALPPNKKELFKDSVRKNKWRLLLGLSAFGLLFVVFYFTHLEVSPVTGRSKLLLVGKEHFRLLSDLEYEVWMEEFKNDLLPERDPRYLTVKEMVYHLTQCNRDVPGISETNWVVHVVDSPAVNAFVLPNGQVFIFTGLLNSVTDVHQLSFLLGHEIAHAVLGHAAEKASLVHLLDFLGMIFLTMIWAICPRDSLAVLGQWIQSKLQEYMFDRPYSRTLEAEADKVGLQLAAKACADVRASSVFWQQMEFSESLHGYPKLPEWLSTHPSHGNRAEYLDRLIPQALKLREVCNCPPLSGPDPRLLFRLTVKRFLEDSEKEDLNITVKKQKTDALPMQKQEQIPLTYVLEKRTAG
Protein: Cyclophilin type peptidyl-prolyl cis-trans isomerase, putative (EC 5.2.1.8) (Q38FI6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Heat shock protein, mitochondrial, putative
- Heat shock protein 83
Sequence:
MAIVGDSLNKRRNYTVCGLVSNPLFQKCAEVAQYVAEEYSDEFYVDIFREMPCEFYSRREQLLNSKKIEDGGMEVIVLVGADGHTGPTNGEGEAMSGDDFLNMMQKATCFRVLNIPPERPDSYENMAHLSWKNYLRERGNTYCWMEISIGEMVHGRVTFELYSRVVPHTCSNFWHLCKGDLSRDADEGEEQVPILSYKNSTFFRTLHGAWVMGGDISGGNGRGGYSIYGRYFPNESYAIPHDRVGVLGMCNDGGDTNASSFYITMKAMQWMNGRYVAFGRVVDGLEVVHAIHAVDVKHNQCPKKVITISDCGVIDLTE
Protein: Calmodulin-binding protein 60 A (C0SVV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds DNA in a sequence-specific manner, likely 5'-GAAATTTTGG-3', to promote the expression of target genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9C9T2}.
Interaction partners:
- Probable calcium-binding protein CML46
- Calmodulin-1
- Probable calcium-binding protein CML47
- Calcium-binding protein CP1
- Protein SAR DEFICIENT 4
- Calmodulin-like protein 10
- Calmodulin-6
- Calmodulin-2
- Isochorismate synthase 1, chloroplastic
Sequence:
MRIPTYDFGSKFSVVQEVMRLQTVKHFLEPVLEPLIRKVVKEEVELALGKHLAGIKWICEKETHPLESRNLQLKFLNNLSLPVFTSARIEGDEGQAIRVGLIDPSTGQIFSSGPASSAKLEVFVVEGDFNSVSDWTDEDIRNNIVREREGKKPLLNGNVFAVLNDGIGVMDEISFTDNSSWTRSRKFRLGVRIVDQFDYVKIREAITESFVVRDHRGELYKKHHPPSLFDEVWRLEKIGKDGAFHRRLNLSNINTVKDFLTHFHLNSSKLRQVLGTGMSSKMWEITLDHARSCVLDSSVHVYQAPGFQKKTAVVFNVVAQVLGLLVDFQYIPAEKLSEIEKAQAEVMVIDALSHLNEVISYDDEVSMMRNVLNAPASQGSVAGIDYSGLSLTSLDGYGFVSSLHNTAECSGKHSDDVDMEVTPHGLYEDYDNLWNCSHILGLEEPQSELQSALDDFMSQKNASVGGKAHSKRWTKLFSVSRWLSVFKYVKLGKI
Protein: DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) (P49917)
Organism: Homo sapiens (Human)
Function: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. LIG4 regulates nuclear localization of XRCC4.
Subcellular location: Nucleus {ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:8798671}.
Interaction partners:
- Non-homologous end-joining factor 1
- DNA-dependent protein kinase catalytic subunit
- X-ray repair cross-complementing protein 5
- X-ray repair cross-complementing protein 6
- DNA repair protein XRCC4
- Protein artemis
- Protein PAXX
- Serine-protein kinase ATM
- DNA excision repair protein ERCC-1
- DNA repair endonuclease XPF
Sequence:
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI
Protein: AGAMOUS-like 79 (MADS-box protein AGL79) (Q7X9H6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- VEFS-Box of polycomb protein
- non-specific serine/threonine protein kinase
- Actin-related protein 2/3 complex subunit 5A
- Receptor protein kinase-like protein At4g34220
- Actin-related protein 2/3 complex subunit 4
- Protease Do-like 4, mitochondrial
- ABSCISIC ACID-INSENSITIVE 5-like protein 8
- VIN3-like protein 3
Sequence:
MGRGRVQLRRIENKIRRQVTFSKRRTGLVKKAQEISVLCDAEVALIVFSPKGKLFEYSAGSSMERILDRYERSAYAGQDIPTPNLDSQGECSTECSKLLRMIDVLQRSLRHLRGEEVDGLSIRDLQGVEMQLDTALKKTRSRKNQLMVESIAQLQKKEKELKELKKQLTKKAGEREDFQTQNLSHDLASLATPPFESPHELRRTISPPPPPLSSGDTSQRDGVGEVAAGTLIRRTNATLPHWMPQLTGE
Protein: Krishah, isoform A (Krishah, isoform C (EC 2.4.2.9)) (LD21741p) (Q9VRQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uridine kinase
- Uridine phosphorylase
- GH09623p
- FI09636p
- Uridine 5'-monophosphate synthase
- Uridine-cytidine kinase
- Serine hydroxymethyltransferase
- purine-nucleoside phosphorylase
- Dihydropyrimidine dehydrogenase [NADP
- UMP-CMP kinase
Sequence:
MRTGSPSSSGSQSEEGSSSSDHQQPQQEAQEQEQQLHTPTHAHAAVPAATSEEILAEYGSNLKLLECNSQVAELLTILRDKNTTRSDFKFYADRLIRLVIEESLNQLPYTHCDVETPTGAIYEGLKYRSGNCGVSIIRSGEAMEQGLRDCCRSIRIGKILVESDANTHEARVVYARFPDDIGSRQVLLMYPIMSTGNTVLQAVNVLREHGVPESCIILSNLFCTPIAARTVVNAFPKLKILTSELHPVAPNHFGQKYFGTD
Protein: Tubulin beta chain (Beta-tubulin) (P02554)
Organism: Sus scrofa (Pig)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7225365}.
Interaction partners:
- Stathmin 4.
- Tubulin alpha chain
- Tubulin alpha-1B chain
- Microtubule-associated protein
- Gap junction alpha-1 protein
- Tubulin alpha chain
- Tubulin alpha 4a
- Tubulin alpha chain
- Tubulin alpha chain
- Tubulin alpha chain
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
Protein: Trehalose-6-phosphate hydrolase (EC 3.2.1.93) (Alpha,alpha-phosphotrehalase) (P28904)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyze p-nitrophenyl-alpha-D-glucopyranoside, but it does not recognize trehalose, sucrose, maltose, isomaltose, or maltodextrins.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:8083158}.
Interaction partners:
- PTS system trehalose-specific EIIBC component
- Trehalose-6-phosphate phosphatase
- Trehalose-6-phosphate synthase
- Periplasmic trehalase
- Cytoplasmic trehalase
- HTH-type transcriptional regulator TreR
- PTS system glucose-specific EIIA component
- Glycogen synthase
Sequence:
MTHLPHWWQNGVIYQIYPKSFQDTTGSGTGDLRGVIQHLDYLHKLGVDAIWLTPFYVSPQVDNGYDVANYTAIDPTYGTLDDFDELVTQAKSRGIRIILDMVFNHTSTQHAWFREALNKESPYRQFYIWRDGEPETPPNNWRSKFGGSAWRWHAESEQYYLHLFAPEQADLNWENPAVRAELKKVCEFWADRGVDGLRLDVVNLISKDPRFPEDLDGDGRRFYTDGPRAHEFLHEMNRDVFTPRGLMTVGEMSSTSLEHCQRYAALTGSELSMTFNFHHLKVDYPGGEKWTLAKPDFVALKTLFRHWQQGMHNVAWNALFWCNHDQPRIVSRFGDEGEYRVPAAKMLAMVLHGMQGTPYIYQGEEIGMTNPHFTRITDYRDVESLNMFAELRNDGRDADELLAILASKSRDNSRTPMQWSNGDNAGFTAGEPWIGLGDNYQQINVEAALADDSSVFYTYQKLIALRKQEAILTWGNYQDLLPNSPVLWCYRREWKGQTLLVIANLSREIQPWQAGQMRGNWQLVMHNYEEASPQPCAMNLRPFEAVWWLQK
Protein: Myocardin-related transcription factor, isoform H (B7Z043)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serum response factor homolog
- Dual specificity mitogen-activated protein kinase kinase dSOR1
- Cell division cycle 14, isoform A
- Serine/threonine-protein kinase tricornered
- Serine/threonine-protein kinase PLK4
- non-specific serine/threonine protein kinase
- Bent, isoform F
- Serine/threonine-protein kinase polo
- Tyrosine-protein kinase-like otk
- Mitogen-activated protein kinase p38a
Sequence:
MPVIADAASDEPPAKCCKHCEESTQSVDGGPASWRLTLDQDLIDTLKGNFPSWFQGSAGGGGGAGGAASKQNPQQHNHQLAQQKHHQLVATSVIPITIDTKLAASNTNTLQQHQQQTAILGHSSSSASPASSVSSNSSKKSISSSLSSCSSSSSNSSSCGSNHCNSKSVSSGAKGAGSATASRFLNKSTSTSPTKSLSRTLKATQKPNGNHKVGQLVKSASLHSLSSGSSGSSSGNSASGSSSLLATISTSPLTTVELISSAACSGLLATRLSGKDLEHSFQDIILLHEAYDDMSEGEQRLHATFLGSSDDGNNSDCYDARQSPPKAIVDSSPLQPAMDKNKESLKVKLMVRRPHSQLVEQGIIPSLKTSPAIHEQCKQLERAKTSDLLKAKIQQRPNREDLERLHILEEDECHIDPSLAEKQRMLKKARLADQLNSQIQHRPGPLELIKKNILHTEKPIEKIVKEGLVSFKATSEGLLTRPQHPHSYVTFDDDSLSSESDTRQTPPRLDEAMVATSSSPTDVLQAAAASAGIVTMALTMPTAGQLVVTSPQILPQQQQPKAIVVPAPVPPPPPPPPPLPMASIIKVKQETANLYEELCQSVTGTTASPVNHLYSPCSLASSTSTLSPLSSIASPPPPPMTTTRLHLAPVSVKSDAPGKDKNRKKSKSKPVSKARTIKFHEYKGPPSAAGQKQDQTQPEETSYQLMLEQQNCLLKFLENLNKNQSIIPAPSAPGVMLPAAPGATNNSITVTTKTVPALASQSAPAPAPISLPNTISITSSSGGAPLNFGDATMLTPTPAATPTPPTLSLIAAPQQQLQLHQQHQQLHQPTPVQHPPPLPSPALSVSSSIPPSPATSYAESTTSSITDLARLEKMKVSDLKQHLKRRNLPVSGPKPHLIERLKPYLPLEPLDSNVTPAPTSNNSNTTPEVITISDAMDTSNCGLLEQPPPVTMLVSDASMEHEQMDVVQQQMDNTHPMTLQTILPPQPQTATIILTNEELLREQQRKIDELQRQLQRSQQELQKIRQRQQQQQHQQQQTVTAQVVNALPSQQITLITTTSNGPQQTLTVMPQQVEKNFPAKVTVKATGGNSNHKVNGLQQQGSAAKKPASSNSNSNSNISSSNPPPINQKMVVKQQLEAKIQKQKAAAAAAAQQQQQQQQQQQQQQQQQALQQQQQQQQQQQQVRLLTQKTQTVFIPFNNNNHINNASAKTTTKKSNVPANNTNTTTATMMQAAKPAAVAAAAASPGNQHHNNLGLLWNEGNQTILLLGLNDQHMTAHTLGNISLTATTTTTAAPPAATPVAASTIAPPKKILNGHQRTNSLPSIVFPIETKSIITQQQLQQLQQQQQQQQQFQPVQQPKQQQLNQVDIKPAPAPPPQYEEATKQLAASKAAALNGLLPLVKIKEEPVQSPAPSAAPLPQTAPLCKRKTASIKSEQVSDVLDILIKQGELPESAALEPITPLTPLPELSMFNGATPTTAAGGASIVPLVPKLETPVTPVQNLDVAMDTNVQHVGFASNQAPNHVFIESIDMASPLQTDSSAIDAESVAKTLDIFLEQHHATPPPSTPPKSCHSGSEKPNSPDAKLNHFDEYELLELMSQQLEMDMGDDSSGYCHASAAKSSNNNGNLRRDLNPSLQPSINELLDASSPDNVLLNNNTGADVDFDADSFVAQLSQHVTGNGNSPGVNCNGSIESSSSAVNSHFGSHSTPMDCDDFESTLNSFMQAVTQPQAGQHVEYATSTSMANGTGGGMGVDNGTGGAVDAFNASGDIFDLFNMDDYKMNWAAGDFTV
Protein: GTP-binding nuclear protein Ran (Q14AA6)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363057}.
Interaction partners:
- Exportin-5
- Exportin-T
- Exportin-1
- Importin subunit beta-1
- Elongation factor 1-alpha 1
- Elongation factor 1-alpha 2
- Nuclear cap-binding protein subunit 1
- Nuclear cap-binding protein subunit 2
- 60S ribosomal export protein NMD3
- Phosphorylated adapter RNA export protein
Sequence:
MAAEGDPPVQFKLVLVGDGGTGKTAFVKRHLTGEFEKKYVATLGVEVHPLMFHTSRGPIKFNVWDTAGQEKFGGLRDGYYIQAQGAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLSRRLTGDSNLEFVAMPALAPPEVVMDPALAKKYEHDLEVAQATALPDEDDDL
Protein: Contactin-6 (Neural recognition molecule NB-3) (hNB-3) (Q9UQ52)
Organism: Homo sapiens (Human)
Function: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Neural cell adhesion molecule L1-like protein
- Receptor-type tyrosine-protein phosphatase gamma
- CD177 antigen
- CD166 antigen
- Basal cell adhesion molecule
- T-cell differentiation antigen CD6
Sequence:
MRLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSRGIQFLEPSTHFLSIVIVIFHCFAIQPLI
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FK66)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Calcium-channel protein CCH1
- Candida glabrata strain CBS138 chromosome M complete sequence
Sequence:
MLHVARLLMRPFTNLNSLEILVQWLRLISSGMVILLSGLVCLAPFTFPKSMYMSKLDAFSADITQGLFDVLRLNMETASLTSINNGVGLTTSELVILTEYTAQQVRSSPQYIVVSLYGRCDCTFTTEQMMDSKGRLYQVQNSTTMCDCIDTGSDYIFDYREVLSNLGLGIILDYAYSKDGSRMGLSTSYSKYINSLRSRKVTVTNLLYAIFVIELVKFCVTFWYYYIKGRFLNIFLEQFLVHTLSIFSLTVFICGLTSVISLAWLNYTVQARIKSELQSFGFSYHLGASWFTCLWMLAFFVSLSCFVWSGLEWCIAENYDPRTSDLKDGFLDRAEESQYENPFDDENVITGEDSNSASSRSGGKLSSSHTEDTGIHGSTSYNNMTRLDSSRIIKNFKNKQFDDTEEQFELQSITLRSSTDSDSSIQRVIQPSSTMHF
Protein: Nuclear calmodulin-binding protein (Q9YHD2)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
GGGGGGGGGSAGGSGPCGGDAAGTAALRAGDEEEEEEEEEEEEEEEEEDEEALLAEEDPQGGGGGRRAAPGTAEEEEEEEEEGGEEGPAEPGKAAQPPVKDEEEVEEEAAVPEQPQAEGPEVGGGVNGAQRAAEPEEGPSGDEAAAAADTDQKEEEEEEEEAAPAADEAKAAGSEAERRGVKRQRDEKDEHGRAYYEFREEAYNSRSKSPPPPEEEPREGEEDESVVILDTYTSDLHFRATKDRYGGQPLFFERFPALWSGARSTHGVTAGKVCFEAKVAQHLPLKEGSTEVPLFRVGWSVDFSRSQLGEDEFSYGYDGRGLKVESGRFEEFGQPFGEGDVIGCFADFEASEEEVELSFSKNGEALGVAFRVPKEALGGRALLPHVLCKGCAVQLNFGQTEPLCPPAPPGYVFIHSVPPEQRVRTPPAPAHLQQCEVLLMVGLPGSGKTQWAQKHSAENQEKRYNMVGTELVLHQMRTRGPEVEELDAKSKDLLIQQAAQCLSKLVQIAPRAKRNFILDQVPPGGVSQTLLGRPPMSLFNFFPPFPPRFGQCNVYNSGQRRKLLAFKGFCRKVVVVVPTEDDWKKRLELRKEAEGEDVPESVMLEMKANYSLPEKSEYLDEVQYGELPKEEAHVGHQIQGGGPETSAPLRETRQPPQQPQQAQPPEPQPRQGYVGGQRRGYDNRIYGQQQYWGPQPGNRGGYRNFYSRYRGDYDRFYGRDYEYNRYRDYYRHYNREWQNYYQDRDRYYRNYGYQGYR
Protein: Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (P50887)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL6
- 60S ribosomal protein L27
- 40S ribosomal protein S27
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein eL39
Sequence:
MAPTAKTNKGDTKTAAAKPAEKKAAPAAAAAKGKVEKPKAEAAKPAAAAAKNVKKASEAAKDVKAAAAAAKPAAAKPAAAKPAAASKDAGKKAPAAAAPKKDAKAAAAPAPAKAAPAKKAASTPAAAPPAKKAAPAKAAAPAAAAPAPAAAAPAVAKPAPKPKAKAAPAPSKVVKKNVLRGKGQKKKKVSLRFTIDCTNIAEDSIMDVADFEKYIKARLKVNGKVNNLGNNVTFERSKLKLIVSSDVHFSKAYLKYLTKKYLKKNSLRDWIRVVANEKDSYELRYFRISSNDDEDDDAE
Protein: Cysteine rich hydrophobic domain 2 (D6RDW7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MADFDEIYEEEEDEERALEEQLLKYSPDPVVVRGSGHVTVFGLSNKFESEFPSSLTGKVAPEEFKASINRVNSCLKKNLPVNVRWLLCGCLCCCCTLGCSMWPVICLSKRLCLHWRLSKRKCETNNMMEYVILIEFLPKTPIFRPD
Protein: Cyclin-B2-5 (G2/mitotic-specific cyclin-B2-5) (CycB2;5) (Q9LM91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Structural maintenance of chromosomes protein 1
- Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger domain-containing protein
- DNA ligase-like protein
- F10B6.17
- Wee1-like protein kinase
- Tubulin-folding cofactor D
- Structural maintenance of chromosomes protein 3
- Probable histone H2A.1
- Putative histone deacetylase 10
- Cyclin-dependent kinases regulatory subunit 2
Sequence:
MNYSNNYIEHQNKKKTIIIFFRQFKKQKPMLRMGVHLVVINKNTFNFFNRQNNYFNSGKTKKIFVIDRFLAVHQIVRKKLQLVGVTALLLACKYEEVSVPVVDDLILISDKAYSRREVLDMEKLMANTLQFNFSLPTPYVFMKRFLKAAQSDKKLEILSFFMIELCLVEYEMLEYLPSKLAASAIYTAQCTLKGFEEWSKTCEFHTGYNEEQLLACARKMVAFHHKAGTGKLTGSTTHLSSFMLQEVNQLGFCFKGGKNYNKNLI
Protein: Putative lipoprotein LppB (P9WK79)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Putative lipoprotein LppA
- Putative antitoxin VapB18
Sequence:
MIAPQPIPRTLPRWQRIVALTMIGISTALIGGCTMGQNPDKSPHLTGEQKIQLIDSMRHKGSYEAARERLTATAQIIADRVSAAIPGQTWKFNDDSYGQDFYRNGSLCKELSADIARRPMAKPVDFGSTFSAEDFKIAANIVREEAAKYGVTTESSLFNESAKRDYDVQGNGYEFNLGQIKFATLNITGDCFLLQKVLDLPAGQLPPEPPIWPTTSTPTP
Protein: Zinc uptake regulation protein (Q9JZ70)
Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Interaction partners:
- Membrane protein
- ABC transporter, ATP-binding protein
- Adhesin
- Probable TonB-dependent receptor NMB0964
Sequence:
MKTNFKQKIIEQARSEGLQVTALREQVLDIVLQQSGVIKAYNVLSQMQQQSEGVLAPPTAYRALDFWAEQGVLHKVAAVNGYILCSHAQHECDDHCHDHEEAEAHHSAFILVCTECGTADEQTLSHEWAALRAGVAESGFALKEEHVVLTGICKKCQQ
Protein: Glycerophosphodiester phosphodiesterase domain-containing 5a (Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1) (E7FGJ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVKHQPLQVYERQLCLSCLTGIYGCRWKRYQRSHDDSSKWECSWFFLLCCSFLLLLVWSYFWLEARNDYNEFNWLLYNRSAVWKDGTVPILATTLTGLTYTAFLMILALCHIALGQQLNLYWIHKIAVLAVFLTTITGVVSIDDFWQDEWDIVIISLQFTGPFLHIGALAAVTALGWVIASQVVRGERSRLQVVTLAVYALILLVLYVVPLFISSPCIMDRSKLGPRPAVIGRRGAPMLAPEHTLMSFSKALQQKVTALEADVAISLDGVPFLMRDRTLRRTTDVDRLFPARQDTDASFFNWTEIRSLNAGLWFLRDDPYWTVQYMSEKDRKRAGNQTVCSLAELLRVAARANRSVIFSLRRPPPNHPRHQLWVSDALKVIQRSSIQPEQVMWTPDWYRKKVRAAVPLLQQTTDEKLPVAELKERGITTLTLHYSQARAQEIRQFSVSNVSVNVYPVNEPWLYSLMWCSGVQSVSSDAPHILKKVPRPIWIMSADEYGLIWITSDLISIAIVVGIFIFQNFHLIRWKMSGMRSYNPEQIMLSAVVRRPSRDVNMMKEKLIFSEINNGVGSTDELSAFTGNGLDVYTHDDIMTPARHTAKL
Protein: Protein gone early (Q9XZ14)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs. Negatively regulates epidermal growth factor receptor (Egfr) signaling. Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, maintaining them in an undifferentiated proliferative state.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25420147}; Single-pass type II membrane protein {ECO:0000255}. Note=Not uniformly present at the cell membrane but is concentrated at the interface between germ cells. {ECO:0000269|PubMed:25420147}.
Interaction partners:
- RT03046p
- Tweedlealpha
- IP11207p
- IP12942p
- GH14155p
Sequence:
MAINQGKYKPSICAIDEVDDRSFKLHNSQDEIGGKQQLQQIEGSETAPLTTNQQKLHMDDGSHLTPKDLEAARQDALNEVAAGGAGGRTPAAITPNSTHPSANGLRALLLPGRRSFDALMSLSRKRRILYVTTACLCALLLLIIILLLAFWPEVPFYLRAPLCLDKECVESSRQLLLWANTSKSPCHETYEWACGNFASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGSVESTVSSLYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDSNRLQSWEYKRVLVVLQAKHGIFPYYRVTVENGFSNPHDYVITLDEGELGLPDKYFYGNDADEEVVRGYKLLLRDFAINMGIVSREADLFADDIFHYERRIVNHIEDAKADANRPINKLMRLADLKIKAPSLPILESLQAIFPKTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHLSKEYRTLAETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMTSKSRGLNKTQGNEELLKLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPTYLAQYYNELILNNVFFVEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQAIAYSNKLNMLLVSKVLISSNYYDYRYPVAVNFARIGTDILEALIDNFSTFLLQFNTQSTDISDAAPEIRYAQPDVNCLAAGQPPRLVHELNELSSNALKSFHVTLSAARTAARALSNFVNAIDAGSAIQGSGIDQANTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCSTTIADKDYARIKPLVESQLAESYLFNATWQHIQFLPRSTNCAAAEATCSNLL
Protein: Transcription factor DIVARICATA (Q8S9H7)
Organism: Antirrhinum majus (Garden snapdragon)
Function: Involved in the dorsovental asymmetry of flowers. Promotes ventral identity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
Sequence:
MEILAPSSYFSSSSWFLEESRSTTRWTAAENKAFENALAVFDENTPNRWERVAERVPGKTVGDVMRQYKELEDDVSSIEAGFVPVPGYSTSSPFTLEWGSGHGFDGFKQSYGTGGRKSSSGRPSEQERKKGVPWTEEEHKLFLMGLKKYGKGDWRNISRNFVITRTPTQVASHAQKYFIRQLSGGKDKRRASIHDITTVNLSDNQTPSPDNKKPPSSPDHSMAQQQTSSTSIHKLPFQWDQTSNETIMGFASSGHHGNMFQSNPFGMNSYGFKMQGQQMQRGGFCDTYLGSQNMAFQMQSGLHFPNA