wanglab/gogpt-training-data huggingface dataset:
Protein: Protein sts5 (O74454)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the maintenance of cell shape during interphase. Required for localization of cortical actin to the growing tips before mitosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8886983}.
Interaction partners:
- Serine/threonine-protein kinase orb6
- Exosome complex component ski6
- Exosome complex component rrp46
- Exosome complex component csl4
- Exosome complex component rrp45
- Exosome complex component rrp43
- Exosome complex component rrp40
- Exosome complex component rrp4
- Exosome complex component rrp42
- Exosome complex component mtr3
Sequence:
MDEEFENDFPYKVMLNQQQDPSDAQSSPTFVPSANPSLTTPWLQTTPSANRPTWLPLQQHMHQLRHTGLLPAVESSFVHGHRRSASAGVGMGNFSNQATIPSNSPAVSNMQPPTQGGQPLYPTNFFTTSVSASSDSFPNSPTVPSKFSLNPSVATSTNISPRRHAKSHSVASVSSPNSHNAVPFTPHAFVPPVNNASPLPALNTLPQLLRPRNLDAQWRPSSLSQTNSPTHAANPSFPGTIVTHNTSNFRPEGGGHRHRRSTGSLSVGSSGSGFSSGGSGNPRKNLFSPYLPQSSIPALLAERRLVTGILIVSKKNRSDAFVSVDGLDAEVFICGSKDRNRALEGDVVAIELLDVDEVWAGKLEKEENRRRKDPISTRGSFDNLRIDAVPFEVPQRSAIKARDDEQVEGQTLFLLDQKQLGADEKPKYAGHVVAVLQRAPGQVFSGTLGILRPSSAANKERQTSSGNQGSSNNSGNDKPKIVWFKPSDKRVPLIAIPTEQAPTDFLGNDQAYAQRLFLASIKRWPVTSLHPFGMLVGELGSMDSMSAQVSALLHDTGVHSEPWEGSAATSAVTALNALSDNFLNVAGCADYRSEDVFLFVKNDVSKAAVSEVKQHESNINSSSATDFVSSAFHIRPTSTGYHVGIHVTDVSRVIEPGSPLDRELQRRSIAVNLCQKSVPLFPTTLGEALSLREDKDCYTMSLLLDVSSTGKIRGTWIGWAVIRPRKAYTMKEADELLQTDARLRLFHTVSSRLRTHHLGTDVPLSRYCRLVRRWDEESCSFDPNETNLFISSAVEVLRETLLDAANRAVASHLRQEFRENAFLRTQRLPSRENCRILQSMAIQMGCVLDLSSTKSLLRSLSLIEDDTVRNILQLYYYKVTPRAVYEMQKYKGNLASQMMSLGIEDESDDLTHFTAPLERYGDIVVHYQLQLLLRGELASEKRLRVWSQAANDASRRLVISKFAQETSIHIKIFSDWAESQVWQDGLVCFVAPSYFDVFFPSLGMEKRVHLDLLNLTHVRFEEDQGILSLYDESGAVTVVKLLTSVKVKLFVQLSTPPLINVSNVEF
Protein: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (Malate dehydrogenase [quinone] cytochrome b small subunit) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit) (Q9CXV1)
Organism: Mus musculus (Mouse)
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O14521}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Fumarate hydratase, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- Succinate--CoA ligase subunit beta, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
Sequence:
MAVLLKLGVLCSGQGARALLLRSRVVRPAYVSAFLQDQPTQGRCGTQHIHLSPSHHSGSKAASLHWTSERVVSVLLLGLIPAGYLNPCSVVDYSLAAALTLHSHWGLGQVVTDYVHGDTLPKAARAGLLALSALTFAGLCYFNYHDVGICRAVAMLWKL
Protein: Peroxisome biogenesis protein 2 (EC 2.3.2.36) (E3 ubiquitin-protein ligase PEX2) (Peroxin-2) (AtPEX2) (AthPEX2) (Pex2p) (Q9CA86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000305|PubMed:12130786, ECO:0000305|PubMed:16169966}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisome biogenesis protein 12
- Light-mediated development protein DET1
- F-box/kelch-repeat protein SKIP6
- Ubiquitin domain-containing protein DSK2b
- Protein APEM9
- E3 ubiquitin-protein ligase SIS3
- Peroxisome biogenesis protein 5
- Peroxisome biogenesis factor 10
Sequence:
MTPSTPADDAWIRSYQRLLPESQSLLASRRSVIPVAISRVNQFDAARLDVEMSAMLKEQLVKVFTLMKPGMLFQYEPELDAFLEFLIWRFSIWVDKPTPGNALMNLRYRDERGVVAQHLGKVRTGLEGPGLTSPQKIWYCVASVGGQYLFSRLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGIYKAASFLNLLSFLYTGRYRNLIEKALKARLVYRSPHMNRSVSFEYMNRQLVWNEFSEMLLLLLPLLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIALPCQHRYCYYCIRTRCASAASFRCLRCNEPVVAIQREGVSSGK
Protein: Probable carboxypeptidase X1 (EC 3.4.17.-) (Metallocarboxypeptidase CPX-1) (Q9Z100)
Organism: Mus musculus (Mouse)
Function: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MWGLLLAVTAFAPSVGLGLGAPSASVPGLAPGSTLAPHSSVAQPSTKANETSERHVRLRVIKKKKIVVKKRKKLRHPGPLGTARPVVPTHPAKTLTLPEKQEPGCPPLGLESLRVSDSQLEASSSQSFGLGAHRGRLNIQSGLEDGDLYDGAWCAEQQDTEPWLQVDAKNPVRFAGIVTQGRNSVWRYDWVTSFKVQFSNDSQTWWKSRNSTGMDIVFPANSDAETPVLNLLPEPQVARFIRLLPQTWFQGGAPCLRAEILACPVSDPNDLFPEAHTLGSSNSLDFRHHNYKAMRKLMKQVNEQCPNITRIYSIGKSHQGLKLYVMEMSDHPGEHELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGDPRVTRLLTETRIHLLPSMNPDGYETAYHRGSELVGWAEGRWTHQGIDLNHNFADLNTQLWYAEDDGLVPDTVPNHHLPLPTYYTLPNATVAPETWAVIKWMKRIPFVLSANLHGGELVVSYPFDMTRTPWAARELTPTPDDAVFRWLSTVYAGTNRAMQDTDRRPCHSQDFSLHGNVINGADWHTVPGSMNDFSYLHTNCFEVTVELSCDKFPHEKELPQEWENNKDALLTYLEQVRMGITGVVRDKDTELGIADAVIAVEGINHDVTTAWGGDYWRLLTPGDYVVTASAEGYHTVRQHCQVTFEEGPVPCNFLLTKTPKERLRELLATRGKLPPDLRRKLERLRGQK
Protein: Suppressor of activated egl-4 protein 1 (A8WHS4)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMDVTSGQPVKSEMLSPIKMETTDPSQQIASPSFLMTSTSLLKQHLHKKSHHNVPSRKASIMALKSQLRTPRGTPLNISTVPGTELPYTPPPILAPMRNGSGLFCQIVKSANSSLPVAEQSPDAPSCSTNGVDGDMKHLMNGKKRSEDGDGPSRKNGFFYMAQQMNQTNFANELEALRKESWASTSSADEKMQTERKESLESIRKASCMSDSYYEIEEGPKISDPNPHINLGKNYQARVKKWCDRQVSTSERDAIEDRDEIVFSSEILQDIDPEQITAFELLACSQACPRAGRNKELALHLLMENKGNIEAAVEDLLRSDTLDWEHYSSVFGYMYNDSVLWTPDEIYQFQDAIYQSEKDFDKVAVELPGKSVKECVQFYYTWKKDCPDDYRKLRNLRRKRQLLDINLQKNQSEEPVVPAKKISIIESGDSDNESNATDSSFIGNGHMEFRDRAFTSPMMSSPREEPIIGLSPSSKDLFGIQKNYQPTAPRAHHTPSASASKKGAQPSADGFFHCRLCDKCFEKVKSLNAHMKSHAMKARAEQEAKAHDAQVAAAAAAQLTSAVGNVVGNPVATSPLNSFANGHLGISIPSTIGNLTPQQLTPQQLNLNQQLQTQLNSLSNQMSLNSPLTPQQQLQQFTQQHLMARAMQQNLFQPVTSTPLVQPTHPLIQAGLHSIN
Protein: Small ribosomal subunit protein uS5x (40S ribosomal protein S2-3) (AtRPS2C) (P49688)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). Also involved in RNA-directed DNA methylation (RdDM).
Interaction partners:
- Small ribosomal subunit protein uS4z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS19z
- Small ribosomal subunit protein eS26x
- Small ribosomal subunit protein eS7y
- Small ribosomal subunit protein eS26z
- Small ribosomal subunit protein eS26y
Sequence:
MAERGGERGVERGGERGDFGRGFGGRGGRGDRGGRGRGGRGGRRGGRASEEEKWVPVTKLGRLVAAGHIKQIEQIYLHSLPVKEYQIIDMLIGPTLKDEVMKIMPVQKQTRAGQRTRFKAFVVVGDGNGHVGLGVKCSKEVATAIRGAIILAKLSVVPVRRGYWGNKIGKPHTVPCKVTGKCGSVTVRMVPAPRGSGIVAARVPKKVLQFAGIDDVFTSSRGSTKTLGNFVKATFDCLQKTYGFLTPEFWKETRFSRSPYQEHTDFLASKALSTSKPDPVVEDQA
Protein: Zinc finger protein 784 (Q8NCA9)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAAARPEAQSRSSPTPESRSQEPLDLVLVPDDCRPGTPPSDLIEIQVVKVTDTTLVPEPPEPGSFHCALCPAAFRLVSELLFHEHGHLAGAEGGGQGGDPSRCHVCGHSCPGPASLRAHYSLHTGERPYRCALCPRAFKALAPLLRHQHRHGVEPGTSRRPPDTAAVAEQRPGVAPERAEVVMAAAAAGAAVGKPFACRFCAKPFRRSSDMRDHERVHTGERPYHCGICGKGFTQSSVLSGHARIHTGERPFRCTLCDRTFNNSSNFRKHQRTHFHGPGPGLGDSGGQLGSSAAEGSGSGCGVGDPAEEGRGETAKVKVEADQ
Protein: Bromodomain PHD finger transcription factor (Q3UPA6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDDNGLPSSKDENVNGESQRKTVITEVTTMTSTVATESKTVIKVAKGDKQTVVSSTENCARSTVTTTTTTVTKLSTPSPDTGVDTISVKEQSKTVVTTTVTDSLTTAGSTLVTSMTVSKEYSTRDRVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGSTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPEAPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIECWVAEEELELWEIRAFAERVEKEKAQAAEQQTKKRLEQQKPAVIAASTTSPANNTSSTVSPAQKVMVAPLSGSVTPGTKMVLATKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGMVQVQQKVLGIIPSTTGPSQQTFTSFQPRTATVTIRPNTSASAGTTTTSQVITGPQIRPGMTVIRTPLQQPALGKAIIRTPVVVQPGTPQQVVTQIIRGQPVSTAISAPSTASSAPVQKGLTPGAAAGPLQPSAPHSPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGMTVLPGPGQQLMQAAMPNGTVQRFLFTPLSTSATAASSSSNSSSTTTNATAAGSGEQKQSKILPQTQVQPATTLAPTQSSSVSPAEAQPQPAQPAAQPQPQPQPPAQPEVQTQPAVSSHVPSETQPSQAQTSKPLVATQCQPQSSVQGQSPVRVQSPPLTRIRPSTPSQVTPGQQPQVQTTASQPIPIPPPTSLQAPSQGQPQSQPQVVMKHNAVIEHLKQKKTMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNASKLSALLFKHKEQLKAEILRKRALLDKELQIQVQEELKRDLKMKREREMAQAVQANAASVPTPSVPAPVPAPAPAAPPAPPRSPPPSTHSLPPAGHPTAPLPVTSQKRKREEEKDSKS
Protein: Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) (P41235)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells.
Subcellular location: Nucleus.
Interaction partners:
- Lymphoid enhancer-binding factor 1
- Catenin beta-1
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear receptor subfamily 0 group B member 2
- Mothers against decapentaplegic homolog 4
- Hepatocyte nuclear factor 1-alpha
- B-cell CLL/lymphoma 9 protein
- Histone acetyltransferase p300
- Forkhead box protein O1
- Nuclear receptor coactivator 1
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Protein: Uncharacterized protein DKFZp781P1017 (Q68DN7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKESLQTGDLLSTFHTISPSFQLKAAALPPFPLGASAQNGLASSLPAEVHSLTLSPPEQAAQPMQPLPESLASLHPSVSPGSPPPPLPNHKYNTTSTSYSPLASLPLKADTKGFCNISLFEDLPLQEPQSPQKLNPGFDLAKGNAGKVNLPKELPADAVNLTIPASLDLSPLLGFWQLPPPATQNTFGNSTLALGPGESLPHRLSCLGQQQQEPPLAMGTVSLGQLPLPPIPHVFSAGTGSAILPHFHHAFR
Protein: HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (Q9JLR9)
Organism: Mus musculus (Mouse)
Function: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000255|PROSITE-ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}. Mitochondrion inner membrane {ECO:0000250}.
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6A1, mitochondrial
Sequence:
MSTNTDLSLSSYDEGQGSKFIRKAKETPFVPIGMAGFAAIVAYGLYKLKSRGNTKMSIHLIHMRVAAQGFVVGAMTLGMGYSMYQEFWANPKPKP
Protein: Outer dense fiber protein 1 (Q61999)
Organism: Mus musculus (Mouse)
Function: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:31475146}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:31475146}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:31475146}. Note=Localizes to the manchette in elongating spermatids and to the sperm flagellum. {ECO:0000269|PubMed:31475146}.
Interaction partners:
- Sperm-associated antigen 4 protein
- Ornithine decarboxylase antizyme 3
- A-kinase anchor protein 3
- Coiled-coil domain-containing protein 42
- Spermatogenesis-associated protein 6
- Spermatogenesis-associated protein 19, mitochondrial
- A-kinase anchor protein 4
- Spermatid nuclear transition protein 1
- Sperm mitochondrial-associated cysteine-rich protein
- SUN domain-containing protein 5
Sequence:
MAALSCLLDSVRRDIKKVDRELRQLRCIDEISSRCLCDLYMHPYCCCDLHPYPYCLCYSKRSRSCGLCDLYYPCCLCDYKLYCLRPSLRSLERLRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDCLGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCTSPCNPCNPCSPCSPCAPCACGPCGPCGPCGPCGPCDPCNPCYPCGSRFSCRKMIL
Protein: ADAM metallopeptidase with thrombospondin type 1 motif 3 (E9Q287)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Collagen and calcium-binding EGF domain-containing protein 1
Sequence:
MVFLSLWLIAASLVEVRTSADGQAGTDEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEHLFFNVTAFGRDFHLRLKPNTHFIAPGAVVEWHETAPRPGNTTDPRNSHLHGSASEGSWRSEPLQTSCAYVGDIMDIPGTSVAISNCDGLAGMIKSDDEEYFIEPLERGKQMDEENGRIHVVYKRSAVEQPPRDVSEDVYHRESDLEGLDDLGTVYSNIGQQLNKTMRRRRHTGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKTDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFVLPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPVWAADEWEHCSRSCGSSGNQLRTVRCLQPLQDGTNRSVHSKYCLGDRPESRRPCNRVPCPAQWKTGSWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRPCQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPSSSGTRAEKKSLSSFSSMANPNADAAFRASSRASADFPRKRAHQAGRKTLESVPSSSSIKTDHLRPASPVAAAPSPAISDSIGASPQTRTPKKDDAKSVSRRHPTRSTASER
Protein: Meiosis-specific nuclear structural protein 1 (Q6PBA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61884}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q2KIQ2}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8NEH6}. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. {ECO:0000250|UniProtKB:Q2KIQ2}.
Interaction partners:
- Outer dense fiber protein 2
- Cilia- and flagella-associated protein 161
- Outer dense fiber of sperm tails 2b.
- EF-hand domain
- Tektin 2
- EF-hand domain family, member B
- Dynein regulatory complex protein 9
- Protein CFAP276
- Tektin
- PARK2 co-regulated.
Sequence:
MILEHRKQEERREDHSKRVVKERQLEANLSCEDRIERKRLLRKLQDEEYGKQIEESLLRAEEDKLFRERQLEQEERMAKELARINNEKLRDEKMRQYIKENSVELRELELKLKSAYLNRERAAQMAEKEAMRYETLREEAMIARTMRDEHELAEMEKEKLEQKKYEEVVRYQQELERQLEEKERKRQEAYEEFLKEKHMVDEIVRKIYMEDQMELQLQLDKMKATQRYIEDFKKQQAEWRRMEREKVEAENRRIIEFAQYQQRKEEDRMAKVREREQAKETLHKMLSEQIELEKQQREKMERAREELCLEEQAEAARQQEIEEMEKRIRQRLELQQTQQEMMAFKKLRLQEEKEEEEAFRQMMMAKFAEDDRIEQMNAQKRRMKQLEHKRAVEQLLEERRQQYLAEQEREEQERAVELEREAQRRKIIEEERQRLLKQHATKLLGYLPKGIFKEEDLEHFDEDFKSNFKQRQADIFSDEGWGDDSQ
Protein: Gamma-aminobutyric acid receptor subunit rho-1 precursor (Gamma-aminobutyric acid type A receptor subunit rho1) (Q5TZ16)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Gamma-aminobutyric acid type A receptor subunit gamma2
- Gamma-aminobutyric acid receptor subunit alpha-2
- Gamma-aminobutyric acid type A receptor gamma1 subunit
- Gamma-aminobutyric acid
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit alpha-4 precursor
- Gamma-aminobutyric acid receptor subunit alpha-5
- Gamma-aminobutyric acid receptor subunit alpha-6
- Gamma-aminobutyric acid
- Gamma-aminobutyric acid type A receptor alpha2 subunit
Sequence:
MHADVCFLLCACFLCTGALQSCSKSRSKRETTRAERDLHKPGSTLLMRSPDVTKAPVTKSEQLLKLDDHDFTMRPGFGGPAIPVGVDVQLESLDTISEVDMDFTMTLYLRHYWKDARLSFPSNTNQSMTFDGRLVKKIWVPDIFFVHSKRSFIHDTTTENVMLRVHPDGKVLYSLRVTVTSMCNMDLSHFPLDTQTCSLEIESYAYTDDDLMLYWKRGNKSLQTDDKISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVIEYAAVNYLSTLQERKERSQNSRQLPCTCGMTHPGQMMMSSSYSEMDMMTTGNYGMSELSDTKQEQFLVHLVMDNEQGAQRPAVTTSSTLNIDTHAIDKYSRVIFPGAYTLFNIIYWSIYSQ
Protein: Nuclear factor I A (Nuclear factor I/A, isoform CRA_c) (A0A590UJU2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPILVPGIKVAASHHPPDRPPDPFSTL
Protein: Tobamovirus multiplication protein 2B (AtTOM2B) (Q8H960)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for the efficient intracellular multiplication of tobamoviruses.
Interaction partners:
- Tobamovirus multiplication protein 2A
- Tobamovirus multiplication protein 1
- Tobamovirus multiplication protein 3
- ADP-ribosylation factor-like protein 8b
- 14-3-3 family protein
- 14-3-3 family protein
Sequence:
MATASENSRGISGGDRTAKAVVADQISQAVNSTANLLHLMRQSSSSQAQLAKLPKNLLAKASLTKATGQALAQLPQVISSLDAHIESGLHSGVHLNTVTQLLENMESTQLRALRQSNISPVV
Protein: Surface presentation of antigens protein SpaP (P40700)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Lipoprotein PrgK
- Surface presentation of antigens protein SpaS
- Surface presentation of antigens protein SpaR
- Invasion protein InvA
- Surface presentation of antigens protein SpaQ
- SPI-1 type 3 secretion system ATPase
- Surface presentation of antigens protein SpaN
- SPI-1 type 3 secretion system secretin
- Protein PrgJ
- Surface presentation of antigens protein SpaM
Sequence:
MGNDISLIALLAFSTLLPFIIASGTCFVKFSIVFVMVRNALGLQQIPSNMTLNGVALLLSMFVMWPIMHDAYVYFEDEDVTFNDISSLSKHVDEGLDGYRDYLIKYSDRELVQFFENAQLKRQYGEETETVKRDKDEIEKPSIFALLPAYALSEIKSAFKIGFYLYLPFVVVDLVVSSVLLALGMMMMSPVTISTPIKLVLFVALDGWTLLSKGLILQYMDIAT
Protein: E3 ubiquitin-protein ligase HAKAI homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase HAKAI) (Q9LFC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:28503769}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28503769}.
Interaction partners:
- FKBP12-interacting protein of 37 kDa
- Protein virilizer homolog
- N
- N6-adenosine-methyltransferase non-catalytic subunit MTB
- RNA demethylase ALKBH10B
- RNA demethylase ALKBH9B
- YTH domain-containing protein ECT4
- YTH domain-containing protein ECT3
- YTH domain-containing family protein
- 30-kDa cleavage and polyadenylation specificity factor 30
Sequence:
MLQIRLRRDSPTETGNGARPSPTETVTVACPDHLVLADLPVAKGIGSVTPTTVIKPVGRRSRRQLGERVHFCVRCDFPIAIYGRLIPCDHAFCLECARSDSICYLCDERIQKIQTIKMMEGIFICAAPHCLRSFLKKLDFEAHVHDLHGSLLQADAEKEDGNQSDVQSTMQQSSASESTLRAPLRSQLQQSRELNRSASFAKSQSGFSQVQNYPPDSDNSRPPGFETASPKPGIRFPDYPQPMNLMQPPSLPVPMNQNPGLPQQFGFPSYPTTESGSSQQFFNGAQYEMTRTESGGSEQSSLLGYPPPSPMTNLNFQGSYPPPSWNPGMAPPHTTQQVNRGRDGQSFGWPQENRDGFGQE
Protein: Twist-related protein 1 (M-twist) (P26687)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.
Subcellular location: Nucleus.
Interaction partners:
- CD44 antigen
- Twist-related protein 2
- Runt-related transcription factor 2
- Cellular tumor antigen p53
- Zinc finger protein SNAI1
- Zinc finger protein SNAI2
- Polycomb complex protein BMI-1
- Ras GTPase-activating protein-binding protein 2
- Transcription factor E2-alpha
- Zinc finger E-box-binding homeobox 1
Sequence:
MMQDVSSSPVSPADDSLSNSEEEPDRQQPASGKRGARKRRSSRRSAGGSAGPGGATGGGIGGGDEPGSPAQGKRGKKSAGGGGGGGAGGGGGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH