wanglab/gogpt-training-data huggingface dataset:
Protein: Rab guanine nucleotide exchange factor SEC2 (GDP-GTP exchange factor SEC2) (P17065)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis. Binds the Rab GTPase YPT32, but does not have exchange activity on YPT32.
Subcellular location: Bud neck {ECO:0000269|PubMed:10747090}. Bud tip {ECO:0000269|PubMed:10747090}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:10747090}. Note=Localizes to sites of polarized growth, namely to the bud neck and to the bud tip of growing buds, and associates with membranes. Colocalizes with secretory vesicles at exocytic sites. Proper localization is dependent on the actin cytoskeleton, MYO2, the kinesin-related protein SMY1, the Rab GTPase YPT32, and the production of post-Golgi vesicles.
Interaction partners:
- Ras-related protein SEC4
- GTP-binding protein YPT32/YPT11
- Exocyst complex component SEC15
- GTP-binding protein YPT31/YPT8
- Myosin-2
- Exocyst complex component SEC10
- Protein DSS4
- Exocyst complex component SEC3
- Protein transport protein SEC9
- Exocyst complex component SEC8
Sequence:
MDASEEAKRVSIQVTSLSTQLIESVDKQSHLEEQLNKSLKTIASQKAAIENYNQLKEDYNTLKRELSDRDDEVKRLREDIAKENELRTKAEEEADKLNKEVEDLTASLFDEANNMVADARKEKYAIEILNKRLTEQLREKDTLLDTLTLQLKNLKKVMHSLDNESTVTNNSNRYSTILSDSATSSSTSLNKVPTSYSLASQDIYSGIVYSPSISSIRYDISLYNEFLKFVAALPRCENIKATSTESKLIRRLVNDEIQPILKIDNASGIGWLVKKTLLSLIIDGLVVVEPLSGVNATYQIGYNSSSPAKQATSNMPKMFKFPLDSPPVAVHAACSFCGESRDDIIEHARMYILKTLHKTDDGKEQVTNTYPLCHWCLLKLRQTCEIFAFLRSLKVGAWHLEKLTTQNITKEDLEKFSEVTKHTKRDGRVSSQDKKTKRLSFMAGLGINSSTKNKPKMEIFSSETNAKPGQPTTNIQRAWLQLCKLRCILHWTHIGIWAVDDSISSKIGPLVEDDSDEDQNDAISVRLQDKALWKQDAKRPFSSSSAEESQKSDAFDFESGDMENEITGESSSDESSSDGSSTDNSTADSSSEDESSLADSTTSSADSSSPESIDNGEGDDTVTKDDKSSIKSANNNEENSDCGDKKGRSIIKKKAPQRKIQKKKLLQDLDDLEEQFREESAIDQTEFENAESNVKQNISSKRASSGDENSKKDNNEKTLKTNLTIGDKTQEQIGENSPSSGLHASSSNDDNFDDAQEQQ
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (Q66MH7)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Interaction partners:
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Uncharacterized protein
- Protein kinase domain-containing protein
- Mitogen-activated protein kinase
- Mo25 family protein
- B2-type cyclin dependent kinase
- Mitogen-activated protein kinase
Sequence:
MKTAKPLKQLKLSVPAQDTPISSFLTASGTFHDGDLLLNQKGLRLISEENESLPSETKEIDLQFSLEDLETIKVIGKGSGGVVQLVRHKWVGTLFALKVIQMNIQEDIRKQIVQELKINQASQCPHVVVCYHSFYHNGAISLVLEYMDRGSLVDVIGQLKTILEPYLAVVCKQVLQGLVYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAMLASSMGQRDTFVGTYNYMAPERISGSTYDYKSDIWSLGMVILECAIGRFPYIQSEDQQARPSFYELLDAIVSSPPPSAPVDQFSPEFCSFVSACIQKDPRDRSSALDLLSHPFVKKFEDKDIDLSILVSSLEPPVNFPR
Protein: Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein homolog) (Importin-alpha re-exporter) (Q9ZPY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- GTP-binding nuclear protein Ran-3
- GTP-binding nuclear protein Ran-1
- GTP-binding nuclear protein Ran-2
- GTP-binding nuclear protein Ran-4
- Importin subunit alpha-4
- Importin subunit alpha-2
- Importin subunit alpha-9
- Importin subunit alpha-7
- Importin subunit alpha-6
- Importin subunit alpha-8
Sequence:
MEWNRETLVFLSQCFLNTLSPIPEPRRTAERALSDAADQANYGLAVLRLVAEPAIDEQTRHAAAVNFKNHLRSRWHPAGDSGISPIVDSEKEQIKTLIVSLMLSASPRIQSQLSEALTVIGKHDFPKAWPALLPELIANLQNAALAGDYVSVNGILGTASSIFKKFSYEYRTDALFVDLKYCLDNFAAPLTEIFLKTSSLIDSAASSGGSPPILKPLFESQRLCCTIFYSLNFQDLPEFFEDHMKEWMGEFKKYLSSNYPALESTEEGLTLVDDLRAAICENINHYIEKNEEEFQGFLNEFASVVWTLLRDVSKSPSRDQLATTAIKFLTSVSTSVHHALFAGDNVIKEICQSIVIPNVSLRVEDEEIFEMNYIEFIRRDMEGSDVDTRRRIACELLKGLATNYKTQVTEVVSLEIQRLLSSFSANPSANWKDKDCAIYLVVSLSTKKAGGASVSTDLIDVQNFFANIILPELQSRDVNSFPMLKAGSLKFLTMFRSHIPKPFAMQLFPELVRFLKAESNVVHSYAASCIEKLLLVKEEGARGNRYAAGDLSPFLLQLMTNLFDALKFPESEENQYLMKCIMRVLGVADISAEVAGPCIGGLTSILSEVCKNPKNPIFNHYLFESVAVLVRRACERDISLISAFETSLFPSLQMILANDITEFLPYGFQLLAQLVELNRPTLSPNYMQIFLLLLSPESWKRSGNVPALVRLLQAFLQKAPHEVTQENRLSQVLGIFEKLVASPSTDEQGFYILNTIIENLDYSVIAPYMKGVWSALFTRVQNKKTVKFQKSLVIFMSLFLVKHGQAYLVETMNTVQPNIITAIVEHFWIPNLKLIMGSMEVKLTAVAATRLICETPALLDPSAAKLWGKMLDSIVTLVSRPEQERVLDEPEMPEISENVGYTAAFVKLHNAGKKEEDPLKDIKDPKQFLVASVSRLSSASPGRYPQIIGENLEQANQTALIQLCNAYNCGIA
Protein: Sporulation-specific protein 2 (P08459)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in middle stages of meiosis. Redundant with SPS22 for the organization of the beta-glucan layer of the spore wall.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Sporulation-specific protein 1
- Chitin deacetylase 2
Sequence:
MPIWKTQTFFTSISVIQIVNKETKVSTKKEKDSMLNQLNTILRFLFLFLQLIKSSAAVEPNGGPNILDHNIMLVNTNATIPKKEQTDFEVISPTKQTQVDEDCKKGLYHIENAGNLIELQAKCWKVVGNIEISSNYSGSLIDLGLIREIEGDLIIKNNKHIFRIQGYNLESLGKLELDSLTSFVSLDFPALKEVETVDWRVLPILSSVVINGNIKKIKNIIISDTALTSIDYFNNVKKVDIFNINNNRFLENLFASLESVTKQLTVHSNAKELELDLSNLHTVENMTIKDVSEIKLAKLSSVNSSLEFIENQFSSLELPLLAKVQGTLGLIDNKNLKKLNFSNATDIQGGLMIANNTELAKIDFFPKLRQIGGAIYFEGSFDKIDLPELKLVKGSAYIKSSSEELNCEEFTSPKAGRSIIRGGKIECTSGMKSKMLNVDEEGNVLGKQETDNDNGKKEKGKNGAKSQGSSKKMENSAPKNIFIDAFKMSVYAVFTVLFSIIF
Protein: Naringenin 7-O-methyltransferase (NOMT) (OsNOMT) (EC 2.1.1.232) (Q0IP69)
Organism: Oryza sativa subsp. japonica (Rice)
Function: S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of O.sativa against pathogen attack.
Interaction partners:
- Os01g0688200 protein
- Hydrolase, alpha/beta fold family protein, putative, expressed
- Os02g0207900 protein
- 4-coumarate--CoA ligase 2
- 4-coumarate--CoA ligase-like 3
- 4-coumarate--CoA ligase-like 9
- 4-coumarate--CoA ligase-like 2
- Probable inactive methyltransferase Os04g0175900
- 4-coumarate--CoA ligase-like 1
- Os11g0205400 protein
Sequence:
MVSPVVHRHAAGGGSGGDDDDQACMYALELLGGSVVSMTLKAAIELGLVDELLAAAGAAVTAEELAARLRLPAAVAAAAAVDRMLRLLASYGVVRCATEAGPDGKARRSYAAAPVCKWLAAGSSSGEGSMAPLGLLNLDKVFMENWYYLKEAVSEGGTAFDKAYGTSLFQYLGQDGNEPSNTLFNQAMASHSVVITNKLLQFFRGFDAGAGVDVLVDVGGGVGATLRMITARHPHLRGVNYDLPHVIAQAPPVEGVEHIGGSMFDHVPSGSAILLKWILHLWGDEECVKILKNCYKALPAKGKVILVEYVLPASPEATLAAQEAFRLDVMMLNRLAGGKERTQQEFTDLAVDAGFSGDCKPTYIFTNVWALEFTK
Protein: E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65) (Q6PJ69)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:34512673}.
Interaction partners:
- Interferon-induced helicase C domain-containing protein 1
Sequence:
MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVCSVCTVRECRLHERALLDAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFDPVSANRHFYLSRQDQQVKHCRQSRGPGGPGSFELWQVQCAQSFQAGHHYWEVRASDHSVTLGVSYPQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSGRLLGMDLDLASGCLTFYSLEPQTQPLYTFHALFNQPLTPVFWLLEGRTLTLCHQPGAVFPLGPQEEVLS
Protein: AT-rich interaction domain 4B (H0Y7Y8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XFECYPPGMKVQVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGSKCE
Protein: Kelch-like protein 18 (E9Q4F2)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Regulates light- and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation. Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form. In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light.
Interaction partners:
- Cullin-3
Sequence:
MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPMACHEGGVGVGCIPLLTI
Protein: TrfB transcriptional repressor protein (Regulatory protein KorA) (P03052)
Organism: Escherichia coli
Function: In conjunction with KorB, inhibits the transcription of kilA, trfA and korAB operons. In conjunction with KorC is responsible for the negative control of kilC and kilE operons.
Interaction partners:
Sequence:
MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQETKR
Protein: Kinesin heavy chain isoform 5A (EC 5.6.1.3) (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) (P33175)
Organism: Mus musculus (Mouse)
Function: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6QLM7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6QLM7}. Perikaryon {ECO:0000250|UniProtKB:Q6QLM7}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {ECO:0000250|UniProtKB:Q6QLM7}.
Interaction partners:
- Kinesin light chain 2
- Kinesin light chain 1
- Kinesin light chain 4
- Kinesin light chain 3
- Kinesin heavy chain isoform 5C
- Trafficking protein, kinesin binding 2
- Kinesin-1 heavy chain
- Trafficking kinesin-binding protein 1
- Mitochondrial Rho GTPase 1
- Neurofilament heavy polypeptide
Sequence:
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQAAPSSTSDMYFASSGATSVAPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETAAS
Protein: Cholesterol oxidase (EC 1.1.3.6) (Cholesterol isomerase) (EC 5.3.3.1) (P9WMV9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Likely catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence.
Subcellular location: Secreted {ECO:0000305|PubMed:24039915}.
Interaction partners:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
- Steroid C26-monooxygenase-3-oxocholest-4-en-26-oate forming])
- Steroid C26-monooxygenase-3-oxocholest-4-en-26-oate forming])
- Inosine-5'-monophosphate dehydrogenase
- Cytochrome bc1 complex cytochrome c subunit
- Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3
- Sulfotransferase
- Tetratrico peptide repeat group 5 domain-containing protein
- Uncharacterized PE family protein PE23
- PE-PGRS family protein PE_PGRS62
Sequence:
MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG
Protein: Uncharacterized protein, isoform G (A0A0B4KH73)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTEFSTNNDHSKPHFTASQQKPHQNSPIHQQAFTPSNPNTHPHLLQRLAQQQQQQQQQQHQRPHKFQQSLPFSQLNNGNNTAAHILPGSSPHSPLSYRNPLNSPSNSPFSNTAQTTIGKRYQQQQLTDRLLQQQHLQQCQQQQLQSLGSSDVEEDLAAEELSEESLKQNVAIVLSNLDRYNNALRSIILNEQVSSSIITPSDSLLFGEDSSGLLYCDNDNSRKHKGNNNFVLGKMAATPESDYNSNATTPGGRSSEQQLQQQQQQQQLGWFLDYGYRDGCGGMQRSVLSSLSASYNAMGDLIYYEDLAKNLDANLAEVDMESFRAEDIHSLLSHLPAYCKSLGGTNSRLQQSLLLQQQQQQQQQLQQQQVLQHNSMLQHMSQTSTTSTNELIDNSFCKSELLFSPVRESHISVDSLDMDAYPDDGEIILTCNKDNYTIAFEGSVLYSDDSFYADPSDIAARNKQNCINLHSNLEDIVKRNKALEVSMSRSAQAFQPLCPMSPKGQAATTSAAKLQRRSLFLVSPARRYPSGNNNTETITITRHLPQCTVRKSSSLPNLQNEEAMAGSCHKEQGPEESGPQAVPLNVSQAISTSTMEAGKSRSRNLLPMCQMPISISVSISERLQQQADQQLPSEQITPTSQQPQQQHHHSHHHRHKHRCSCSQESHISGSASSGNSSNPPAFNLVKLFIKQKSSNSSGGQEDLGAQASAHTCMDVSSGCWPSSDAASSSSGSLEQRLRKKSMNDSGKGSAVSRHDEEEHYPDTETPRRQLRARSEAVFYDDVASSSSTGSLTATNSPAHRRRSMPLRNPQLYQLAAQVSTGSQMSSEASSEQLTQVPRRAEAGCGTSTRPLSCASSSEMITRSMQTSCGSLSTTRSSLSDRYRCVPPSFLEKLNNLGEERQAPIYVIYPNYALPDLGFVKTNASTDVIFSPFNYKMTMDGATGSTSSSGSLRKQRNSSQSVSEDEILKTLDYKHVADWQSLATLLPSEYRRRLQHIPEVKHLVRQLDAELSQRPLFCMSPPLRRNRTHICDCAKYFQGQQTQTDEASSSGSSQQPSSGYRGSSTLLTDSELDVDPLKQMYVYQYDQQRMDSGVETSPGSQLTQTPPQPMPRSILRKAHSAQSRSKRNSMIEAQQTQKLTKLEKRRSLQEPPNNYGLGSTDELADVFEEEEHSQPAPPVKQRLSRKDLDARARAESFLASLPRSELKYYAEIASILESSGEHVTYDAAALKKEVSRVLSQQKKVSFNDEGVAAGLQQHAKRFATPPNSPNISMGALKRDTVDVLEQRKIESNRFKRLQIQWELMSKDSSMLKELASEAATKSGGSTPTSGNSTGSNSAPRSRIPRPVSYPAGSSTPTSSRTAPVLATPSPARPATPKTVTKSHNKPGLFTSPRPSRLTSAQEAAGGNKVSTRSPSRIVQPKRYSLAGATTPTSTTPTSARARTPTNRVAVTAPNTPKRQAVAQSPRPTSRVR
Protein: L-ribulose-5-phosphate 4-epimerase UlaF (EC 5.1.3.4) (L-ascorbate utilization protein F) (Phosphoribulose isomerase) (P39306)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
Interaction partners:
- L-ribulose-5-phosphate 3-epimerase UlaE
- Putative L-ribulose-5-phosphate 3-epimerase SgbU
- Ribulokinase
- L-arabinose isomerase
- 3-keto-L-gulonate-6-phosphate decarboxylase UlaD
- Ascorbate-specific PTS system EIIA component
- Ascorbate-specific PTS system EIIB component
- Probable L-ascorbate-6-phosphate lactonase UlaG
- Ascorbate-specific PTS system EIIC component
- L-ribulose-5-phosphate 4-epimerase SgbE
Sequence:
MQKLKQQVFEANMELPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKAADMVVVDMSGKVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSEEEVQGEYELNTGKVIIETLGNAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARGINPQLNHIDSFLMNKHFMRKHGPNAYYGQK
Protein: Protein kinase superfamily protein (F4JRQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable disease resistance protein At1g62630
- Probable disease resistance protein At1g12290
- Disease resistance RPP8-like protein 3
- Probable disease resistance protein At1g59620
- Putative disease resistance protein At3g14460
- Putative disease resistance RPP13-like protein 2
- Putative disease resistance RPP13-like protein 1
- Disease resistance protein At4g27190
Sequence:
MHAIDFKEIQEKLSDGFRPWQRSFQFWARATDIYTGYKVFQLRMNFVKDVNKHEEMWERQHELAAHKVYSMCSDLGGFFLKIAQILGKPDLAPAAWVRKLVTLCDQAPATPFDAVRVVLEKELGKSIEQVFETFDEKPLGSASIAQVHRARVKGDKRDVVVKVQHPGVEKLMMVDIRNLQIFALYMQKTDIKFDLFSMTKEIEKQIGYEFDFKREANAMEKIRRFLYDNNRKSPVLVPRVFPNLVTRKVLVMEFMNGIPILSLGDEMAKRGINPHGKMAEAAKFNILHSLSQAYGQMILKSGFFHADPHPGNILIGKGSEVALLDYGQVKELPDHLRLGYANLVIAIADNNASLALQSFRELGIATVAKCKNEQQELLQLAKTMFDTEMPPGTTTLQPFSEDSSIKKISVEAFPEELFSVLRTVVLLRGLSVGIGINYSCAQHWRAMAEEALHASGRLSTGRKQKRRCSSLRRLYPGPRES
Protein: ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multidrug resistance-associated protein 3) (B2RX12)
Organism: Mus musculus (Mouse)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:16225954}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Basal cell membrane {ECO:0000250|UniProtKB:O15438}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- Hepatic sodium/bile acid cotransporter
- Solute carrier organic anion transporter family member 1A4
- Prolactin-2C3
- Solute carrier organic anion transporter family member 2B1
Sequence:
MDRLCGSGELGSKFWDSNLSIYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLFYLRHHQLGYIVLSWLSRLKTALGVLLWCVSWVDLFYSFHGLIHGSSPAPVFFVTPLVVGITMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTTFYIYFALVFCALILSCFKEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAKDAGLA
Protein: Oryza sativa mitochondrial plasmid-like gene (B1) for 2 ORFs (O47940)
Organism: Oryza sativa (Rice)
Interaction partners:
Sequence:
MPKTLTKTFVPVFLSGMTSLSCRHSVPQLPQLLGCSESSRTPARHPPGNARGCFKKRVMWVPIILGLVPRHQANPIPFRW
Protein: V-type proton ATPase subunit C (V-ATPase subunit C) (Vacuolar proton pump subunit C) (Q9XXU9)
Organism: Caenorhabditis elegans
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (Probable). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). Has roles in embryogenesis and ovulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10846178}. Membrane {ECO:0000269|PubMed:11441002}; Peripheral membrane protein {ECO:0000305}. Note=In embryonic cells, detected in dot-like structures in the cytoplasm around the nuclei. {ECO:0000269|PubMed:10846178}.
Interaction partners:
- Probable V-type proton ATPase subunit H 2
- V-type proton ATPase subunit D
- Probable V-type proton ATPase subunit G
- Probable V-type proton ATPase subunit F
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit B 1
- V-type proton ATPase subunit
- V-type proton ATPase subunit S1
- V-type proton ATPase subunit e
Sequence:
MSSATSGEYWLISVPGEKGANDAWDKLNRSTGNTSTNSKYLIPDLKVGTLDQLVGLSDDLSKLDTSAEAVIRKLVQYFTEVLEEDKSKIAENLVIGNKDMKTYVTKFQWEGAKYPLKQSLKVLSEIIGKQISQIDNDLKVKSLTYNNLKNALASMDRKTVGSLLTKDLADLVKADDFVLNSEYLQTVIVVVPKISVKEWEQKYATLSSMVVPGSSKLLTEEGEHALYTVTLFKKVIDEFKNTARENKFIVRDFVYDEETLKAGRTERDKLMAEKQRQYAPLIRWLKINFGEIFAAYIHIKALRVFVESVLRYGLPVNFQAAVIEPAKGQQKKLRQELHKLYIHLDGSAAGPIDTLEDSPALMSLGVNEYYPYVFFKLNIDFLNK
Protein: DEAD-box ATP-dependent RNA helicase 55 (EC 3.6.4.13) (Q9FVV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome biogenesis protein WDR12 homolog
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar complex-associated protein 3
- Probable rRNA-processing protein EBP2 homolog
- AT5g04600/T32M21_200
- Probable ribosome biogenesis protein RLP24
- Pescadillo homolog
- rRNA methyltransferase 2
- Putative rRNA methyltransferase
- 60S ribosome subunit biogenesis protein NIP7 homolog
Sequence:
MDSSPPNTIIEEAPPRFSELKPPLSEDIIEALDRSGFEVCTPVQAETIPFLCSHKDVVVDAATGSGKTLAFLLPFIEIIRRSNSYPPKPHQVMGVIISPTRELSAQIHKVARAVRLDFAKCREVEADMNTLEEEGANLLIGTPGRLSDMMKRMEFLDFRNLEILILDEADRLLDMGFQKQVNYIISRLPKQRRTGLFSATQTQAVADLAKAGLRNPYLKCEADQKSSQLVHLLIENKNKKLVVFFMTCACVDYWGLVISKIPSLKSISFFPTHGKMDQKGRDTALASFTEASSGVLLCTDVAARGLDIPGIVYIRSLAIKDREVLEKGLKAFVSFVRAYKEHQCSYIFSWKGLEIGKLAMGYGILSFPYISEVKQDRIGIVGFTPVQGITFEDIKFKNKSREKQRQQNLLARKDKLQQEKRGKRKKSSKEAVDDSNKASRKRKLTGRQRQTIQTAQDEEEMNLRL