wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate decarboxylase 5 (GAD 5) (EC 4.1.1.15) (Q9LSH2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).
Interaction partners:
- Gamma-aminobutyrate transaminase POP2, mitochondrial
- Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial
- Probable glutamate dehydrogenase 3
- glutamate dehydrogenase
- Glutamate dehydrogenase 1
- Glutamate dehydrogenase 2
- Pantoate--beta-alanine ligase
- Argininosuccinate synthase, chloroplastic
- Glutamate synthase 1, chloroplastic
- Beta-ureidopropionase
Sequence:
MVLATNSDSDEHLHSTFASRYVRAVVPRFKMPDHCMPKDAAYQVINDELMLDGNPRLNLASFVTTWMEPECDKLIMDSVNKNYVDMDEYPVTTELQNRCVNMIANLFHAPVGEDEAAIGCGTVGSSEAIMLAGLAFKRKWQHRRKAQGLPIDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEDYYVMDPAKAVEMVDENTICVAAILGSTLTGEFEDVKQLNDLLAEKNAETGWETPIHVDAASGGFIAPFLYPDLEWDFRLPWVKSINVSGHKYGLVYAGVGWVVWRTKDDLPEELVFHINYLGADQPTFTLNFSKGSSQIIAQYYQFIRLGFEGYKNIMENCMDNARRLREGIEMTGKFNIVSKDIGVPLVAFSLKDSSKHTVFEIAESLRKFGWIIPAYTMPADAQHIAVLRVVIREDFSRGLADRLITHIIQVLKEIEGLPSRIAHLAAAAAVSGDDEEVKVKTAKMSLEDITKYWKRLVEHKRNIVC
Protein: U6 snRNA-associated Sm-like protein LSm3p (Q57TX5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQTSRALFEAMDPFVFLLQSVDCPVRVHTVNRETTSGTLLAVDDHCNIMLKDWSTTGHLPSIEGAAPASLRFIRGEQIRTITLAPQSYQVN
Protein: BolA-like protein 3 (Altered inheritance of mitochondria protein 1) (P39724)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein. Acts together with NFU1, later than BOL1 and GRX5 in the [4Fe-4S] cluster insertion process. Not required for [2Fe-2S] cluster insertion into mitochondrial proteins.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:27532772, ECO:0000305|PubMed:27532773}.
Interaction partners:
- BolA-like protein 1
- Monothiol glutaredoxin-3
- Monothiol glutaredoxin-5
- NifU-like protein
- Fe-S cluster assembly protein DRE2
- Lipoyl synthase, mitochondrial
- BolA-like protein 2
- Monothiol glutaredoxin-4
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
- Iron-sulfur assembly protein 2
Sequence:
MKLPQTMLRSISVKHVRWPRILTGSKLWYSTQMAMTPEEKMITDKLQQELEPEVCKVQDVSGGCGSMFAINITSKKFNGLSLIKQHQLVNRILRDDISRWHGLQLTTKKSTGKGPASS
Protein: Homeobox protein Hox-D4 (Homeobox protein Hox-4.2) (Homeobox protein Hox-5.1) (P10628)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-D3
- Homeobox protein Hox-D8
- Homeobox protein Hox-B7
- Homeobox protein Hox-B5
- Homeobox protein Hox-C6
- Homeobox protein Hox-B6
- Homeobox protein Hox-B4
- Homeobox protein Hox-C4
Sequence:
MAMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGSGAQGADFQPSGLYPRPDFGEQPFGGGGPGPGSALPARGHGQEPSGPGSHYGAPGERCPAPPPAPLPGARACSQPTGPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSCSSSAAPGQHLQPMAKDHHTDLTTL
Protein: Glucosyltransferase 3 (EC 2.4.1.-) (A0A0H2UR93)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Required for polymorphic O-glycosylation of the serine-rich repeat protein PsrP. Catalyzes the second step in glycosylation of the serine-rich repeat protein in this bacteria. Transfers glucose from UDP-glucose to the terminal GlcNAc moiety of 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] which results from the first glycosylation step of PsrP (using the short substrate SRR1-GlcNAc). Has weak hydrolytic activity against UDP-glucose and even weaker activity on UDP-galactose. Does not complement deletion of the gtf3 gene from S.parasanguinis strain FW213.
Interaction partners:
Sequence:
MKLHLTNLYGMAGDSTVILAQNAVQKIASQLGFREVGIYFYNIASDSPSEMNKRLDGIMASISIGDILVFQSPTWNGFEFDRLLFDKLKDMQVKIICFIHDVVPLMFDSNYYLMKDYLYMYNLSDVLIVPSERMKTRLMEEGLTTKKILVQGMWDHPHDLSLYTPAFKKELFFAGSLERFPDLQNWSQDTPLRVFSNKGEASSSARSLSIEGWKKDEELLLELSKGGFGLVWGTHQNEGESNQYYTLNISHKVSTYLTAGIPVIVPSSLSTAKFIVDQGLGFMADSLEEVHEIVDKMNLQEYQEMTNRIKTFSYLLKEGYFTKKLLVDAIYHLGID
Protein: CRE-binding bZIP protein SKO1 (Q02100)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes.
Subcellular location: Nucleus.
Interaction partners:
- Mitogen-activated protein kinase HOG1
- General transcriptional corepressor TUP1
- General transcriptional corepressor CYC8
- General control transcription factor GCN4
- High-osmolarity-induced transcription protein 1
- Zinc finger protein MSN2
- Zinc finger protein MSN4
- AP-1-like transcription factor YAP1
- Mitogen-activated protein kinase FUS3
- Transcription factor SKN7
Sequence:
MSSEERSRQPSTVSTFDLEPNPFEQSFASSKKALSLPGTISHPSLPKELSRNNSTSTITQHSQRSTHSLNSIPEENGNSTVTDNSNHNDVKKDSPSFLPGQQRPTIISPPILTPGGSKRLPPLLLSPSILYQANSTTNPSQNSHSVSVSNSNPSAIGVSSTSGSLYPNSSSPSGTSLIRQPRNSNVTTSNSGNGFPTNDSQMPGFLLNLSKSGLTPNESNIRTGLTPGILTQSYNYPVLPSINKNTITGSKNVNKSVTVNGSIENHPHVNIMHPTVNGTPLTPGLSSLLNLPSTGVLANPVFKSTPTTNTTDGTVNNSISNSNFSPNTSTKAAVKMDNPAEFNAIEHSAHNHKENENLTTQIENNDQFNNKTRKRKRRMSSTSSTSKASRKNSISRKNSAVTTAPAQKDDVENNKISNNVTLDENEEQERKRKEFLERNRVAASKFRKRKKEYIKKIENDLQFYESEYDDLTQVIGKLCGIIPSSSSNSQFNVNVSTPSSSSPPSTSLIALLESSISRSDYSSAMSVLSNMKQLICETNFYRRGGKNPRDDMDGQEDSFNKDTNVVKSENAGYPSVNSRPIILDKKYSLNSGANISKSNTTTNNVGNSAQNIINSCYSVTNPLVINANSDTHDTNKHDVLSTLPHNN
Protein: Acid stress protein IbaG (P0A9W6)
Organism: Escherichia coli (strain K12)
Function: Involved in cell resistance against acid stress.
Interaction partners:
- Glutaredoxin 4
- DNA-binding transcriptional regulator BolA
- Intermembrane phospholipid transport system binding protein MlaB
- Intermembrane phospholipid transport system binding protein MlaD
- Intermembrane phospholipid transport system permease protein MlaE
- Intermembrane phospholipid transport system binding protein MlaC
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Sequence:
MENNEIQSVLMNALSLQEVHVSGDGSHFQVIAVGELFDGMSRVKKQQTVYGPLMEYIADNRIHAVSIKAYTPAEWARDRKLNGF
Protein: SAGA-associated factor 73 (O94397)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Sgf11 is involved in transcriptional regulation of a subset of SAGA-regulated genes and is required for histone H2B deubiquitination (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SAGA complex subunit Spt7
- SAGA complex subunit Sgf11
- SAGA complex/transcription factor TFIID complex subunit Taf6
- SAGA complex/transcription factor TFIID complex subunit Taf9
- SAGA complex subunit Ngg1
- SAGA complex subunit Sgf29
- SAGA complex subunit Sus1
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex subunit Hfi1
- Probable ubiquitin carboxyl-terminal hydrolase 8
Sequence:
MLTEQQTLELFPENWERNEQVLLKYPDGLPKDVLADQRVDNTESQVKDEITSNITNQTQILLPADSFPQYGSYPNNSELDYVVCTKCDRPFLSEYIEDHHSSCNGIKPPKPQFEPVANSQVLNKDVNNGNNAPIKNGVKSTAKGSAGNHEKNSVNGQKNPEMPPKRRKTEENKKPTKSALPKKEASKKKNPKVKGPVDVEKQCGVLLPNGQMCARSLTCKTHSMSSKRAVPGRSQPYDVLLAACQKKNQVKIQRQILETAKESEDNQHQAPVDSDEEVSFIMNVLQKSGNQPLEQKVFLPVKRRHSYFRTRELIAAAFRHGEQGMQVTGTILGRVIPFSARQPL
Protein: Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit (P37180)
Organism: Escherichia coli (strain K12)
Function: Probable b-type cytochrome.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Hydrogenase-2 large chain
- Hydrogenase-2 small chain
- Hydrogenase-2 operon protein HybA
- Hydrogenase-2 operon protein HybE
- Hydrogenase 2 maturation protease
- Hydrogenase-1 large chain
- Hydrogenase maturation factor HybF
- Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit
- Dimethyl sulfoxide reductase DmsA
- Formate dehydrogenase-O major subunit
Sequence:
MSHDPQPLGGKIISKPVMIFGPLIVICMLLIVKRLVFGLGSVSDLNGGFPWGVWIAFDLLIGTGFACGGWALAWAVYVFNRGQYHPLVRPALLASLFGYSLGGLSITIDVGRYWNLPYFYIPGHFNVNSVLFETAVCMTIYIGVMALEFAPALFERLGWKVSLQRLNKVMFFIIALGALLPTMHQSSMGSLMISAGYKVHPLWQSYEMLPLFSLLTAFIMGFSIVIFEGSLVQAGLRGNGPDEKSLFVKLTNTISVLLAIFIVLRFGELIYRDKLSLAFAGDFYSVMFWIEVLLMLFPLVVLRVAKLRNDSRMLFLSALSALLGCATWRLTYSLVAFNPGGGYAYFPTWEELLISIGFVAIEICAYIVLIRLLPILPPLKQNDHNRHEASKA
Protein: MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) (Q9HAP2)
Organism: Homo sapiens (Human)
Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Interaction partners:
- Carbohydrate-responsive element-binding protein
- Max-like protein X
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta
- Max dimerization protein 4
- 17-beta-hydroxysteroid dehydrogenase type 1
- Thioredoxin-interacting protein
- Exportin-1
Sequence:
MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDDSDTDEPSPPPASGAATPARAHASAAPPPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLVQDDDMLYWHKHGDGWKTPVPMEEDPLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNNPPAQESILPTTALPTVSLPDSLIAPPTAPSLAHMDEQGCEHTSRTEDPFIQPTDFGPSEPPLSVPQPFLPVFTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSVITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRPPQPRLTFVHPKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKREGMLASTVSQSNVVIAPAAIARAPGVPEFHSSILVTDLGHGTSSPPAPVSRLFPSTAQDPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKNRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHMKDMFDEYVKTRTLQNWKFWIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDPAQLPEQASKAVTRIGKRLGES
Protein: Probable WRKY transcription factor 31 (WRKY DNA-binding protein 31) (Q93WT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
Interaction partners:
Sequence:
MFRFPVSLGGSRDEDRHDQITPLDDHRVVVDEVDFFSEKRDRVSRENINDDDDEGNKVLIKMEGSRVEENDRSRDVNIGLNLLTANTGSDESTVDDGLSMDMEDKRAKIENAQLQEELKKMKIENQRLRDMLSQATTNFNALQMQLVAVMRQQEQRNSSQDHLLAQESKAEGRKRQELQIMVPRQFMDLGPSSGAAEHGAEVSSEERTTVRSGSPPSLLESSNPRENGKRLLGREESSEESESNAWGNPNKVPKHNPSSSNSNGNRNGNVIDQSAAEATMRKARVSVRARSEAAMISDGCQWRKYGQKMAKGNPCPRAYYRCTMAGGCPVRKQVQRCAEDRSILITTYEGNHNHPLPPAATAMASTTTAAASMLLSGSMSSQDGLMNPTNLLARAILPCSSSMATISASAPFPTITLDLTNSPNGNNPNMTTNNPLMQFAQRPGFNPAVLPQVVGQAMYNNQQQSKFSGLQLPAQPLQIAATSSVAESVSAASAAIASDPNFAAALAAAITSIMNGSSHQNNNTNNNNVATSNNDSRQ
Protein: oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase) (A0A140VJQ5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVRPRERRARQIVKAPCSSMEFRSPT
Protein: Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293) (O00238)
Organism: Homo sapiens (Human)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19726563}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein 4
- Bone morphogenetic protein 2
- Growth/differentiation factor 5
- Bone morphogenetic protein 6
- Bone morphogenetic protein 7
- Bone morphogenetic protein receptor type-1A
- Activin receptor type-1
- Bone morphogenetic protein 15
- Growth/differentiation factor 6
Sequence:
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
Protein: DNA-binding response regulator (Q728L5)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MNILIVEDDATIAATTAQALVDAGNEAMVASTLDEAREKAGSGAWDAIVLDLMLPDGDGADLLHELRERGDTVPVLVLSARQSVEDRVRHLESGSDDYLTKPFAISELLARLAALRRRSAGRPMSLTHSGLMLDLVHRKAYRDGCEMDLKGREFALLLLLMENAGTVVTRNMIVKRVWGYDFMPGSNIIDVQICQLREKTERNGAPRVIHTMRGVGYVFGLADAVA
Protein: NAD(P)-binding Rossmann-fold superfamily protein (Putative oxidoreductase) (Q94AL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Zeaxanthin epoxidase, chloroplastic
- Molybdenum cofactor sulfurase
- Abscisic-aldehyde oxidase
Sequence:
MSNHQTQVLKLLEPWCELKDKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAALELDVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKSSLDLSEDEWDNVFKTNLKGPWLVSKHVCMLMRDAKRGGSVINISSIAGIRGMLPGGLAYACSKGGVDTMSRMMALELGVHKIRVNSIAPGLFKSEITQGLMQKEWLKNVTERTVPLKVQQTVDPGLTSLVRYLIHDSSQYISGNTYIVDSGATLPGVPIFSSL
Protein: Protocadherin 19 (Protocadherin-19 isoform X1) (A0A2R8QME5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MHSKDMDFVQMFVCFLLCWTGVDAVFNLKYTVEEELRAGTKIANVTADAKVAGFALGNRQPYLRVISNSEPRWVNLSPAGLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVNDNAPRFPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIFGLEIKTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQLNIKVIDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFINFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPAHCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDSGANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDSGYPPLRSSKSFAVKVTDENDNPPYFTKPHYQAMVLENNVPGAFLLAVSARDPDLGMNGTVSYEIIKSEVRGMSVESYVTVNSNGEIYGVRAFNHEDTRTFEFKVSAKDGGDPPLTSNATVRIVVLDVNDNTPVMTTPPLVNGTAEVSIPKNAGVGYLVTQIKADDYDEGENGRLTYSISEGDMAYFEIDQINGEVRTTKTFGENAKPSYQITVVAHDHGQTSLSASAYIVIYLSPDLNAQEQIGPVNLSLIFIIALGSIAVILFVTMIFVAVKCKRDNKEIRTYNCSFLYLRRVAEYSYGNQKKSSKKKKLSKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNSRNAAPNHGYHHTFTGQGPQQPDLIINGMPLPETENYSIDSSYVNSRAHLIKSTSTFKDMEGNSLKDSGHEESDQTDSEHDVQRGHYADTAVNDVLNMTVPSNNSQIPDQDQSEGFHCQDECRILGHSDRCWMPRVPIPARAKSPEHGRNVIALSIEATTVDVPHYEDCGTTKRTFATFGKDGPDEDRAEQRGRRQTAEPAVCSPKTNGAVREAGNGREAVSPITSPVHLKSPQSKASSTYNTLKCRDAERIANHSLLRQPEGKDSEPAMREINTLLQDGRDKESPGSKRLKDIVL
Protein: MCL1 apoptosis regulator, BCL2 family member (A0A087WT64)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Protein: L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) (P07195)
Organism: Homo sapiens (Human)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm. Mitochondrion inner membrane {ECO:0000269|PubMed:27618187}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
Protein: Serine/threonine-protein kinase CAK1 (EC 2.7.11.22) (CDK-activating kinase) (P43568)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-2
- G2/mitotic-specific cyclin-1
- Cyclin-dependent kinases regulatory subunit
- Serine/threonine-protein kinase KIN28
- M-phase inducer phosphatase
- Mitosis inhibitor protein kinase SWE1
- Hsp90 co-chaperone Cdc37
- Cell division control protein 6
- Cyclin CCL1
Sequence:
MKLDSIDITHCQLVKSTRTARIYRSDTYAIKCLALDFDIPPHNAKFEVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEEMNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTDISTGIYKAPEVLFGVKCYDGGVDVWSLLIIISQWFQRETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEKLGIPSIQKWEEVAQHGSVDAFVGMFGADGDGKYVLDQEKDVQISIVERNMPRLDEIADVKVKQKFINCILGMVSFSPNERWSCQRILQELEKP
Protein: Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (GalNAc-T1) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) (pp-GaNTase 3) (P34678)
Organism: Caenorhabditis elegans
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
- GLY-16
Sequence:
MLSVGGGRSAVCRAVIATSIVWLLIDVVILFYYLDPSTSQQQPFPEDNRILNRARRIEPLPPAAQHDSDPDAHPIQPEKQEKQVYPVDKETANQLRKLMETQAFGPGYHGQGGTGVTVPEDKKTIKEKRFLENQFNVVASEMISVNRTLPDYRSDACRTSGNNLKTAGMPKTSIIIVFHNEAWTTLLRTLHSVINRSPRHLLEEIILVDDKSDRDYLVKPLDSYIKMFPIPIHLVHLENRSGLIRARLTGSEMAKGKILLFLDAHVEVTDGWLEPLVSRVAEDRKRVVAPIIDVISDDTFEYVTASETTWGGFNWHLNFRWYAVPKRELNRRGSDRSMPIQTPTIAGGLFAIDKQFFYDIGSYDEGMQVWGGENLEISFRVWMCGGSLEIHPCSRVGHVFRKQTPYTFPGGTAKVIHHNAARTAEVWMDEYKAFFYKMVPAARNVEAGDVSERKKLRETLQCKSFKWYLENIYPEAPLPADFRSLGAIVNRFTEKCVDTNGKKDGQAPGIQACHGAGGNQAWSLTGKGEIRSDDLCLSSGHVYQIGSELKLERCSVSKINVKHVFVFDDQAGTLLHKKTGKCVTGADQRVTLDECGLGRKDQMWQLEGYQSP
Protein: Heat shock protein 75 kDa, mitochondrial (TNF receptor-associated protein 1) (Trap1 protein) (A8WFV1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MIRSLNLLKYSLNVSQRAQLRLLSSSKWTGHRIVPAAFTGVDTNGRQQLHQPRPFRLWSPSCSGVSVHHRSYSTQQHTEPAEEETLHNIITDTENVQGSFSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNGSDALEKLRHRMITAGGDTAPMEIHLQTDSVKGTFTIQDTGVGMNKEDLVSNLGTIARSGSKAFLDALQNQAEASSSIIGQFGVGFYSAFMVADKVEVYSQSAEADAPGYKWSSDGSGVFEVAEASGVRQGTKIVLHLKDDCKEFSSEDRVKEVVTKYSNFVSFPIFLNGRRLNTLQALWMMEPKDISEWQHEEFYRYVAQAYDKPRYTLHYRADAPLNIRSIFYVPEMKPSMFDVSREMGSSVALYSRKILIQTKATDILPKWLRFLRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRVIRFLLDQSKKDPEKYARFFEDYGLFMREGIVTTGEQSVKEDIAKLLRFESSALPAGQQTSLMEYSSRMKAGTRNIYYLCAPNRHLAEHSPYFEAMKQKDMEVLFCFEQFDELTLLHLREFDRKKLISAETDIVVDHYKEEKFQDSKPASERLSSEQAEDLLAWMRNALVQRVTNIKVTPRLDTHPAMITVLEMGAARHFLRTQQLARSSEERAQILQPTLEINTGHDLIKKLHALKDSNPELAQLLLEQIYDNAMIAAGLNEDPRPMISRLNQLLTRALEKH
Protein: Probable ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (O94269)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Putative G3BP-like protein
- Probable ubiquitin carboxyl-terminal hydrolase 2
- Ubiquitin carboxyl-terminal hydrolase 6
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin thioesterase otu2
- Putative ubiquitin thioesterase otu1
- Probable ubiquitin carboxyl-terminal hydrolase 12
- Ubiquitin carboxyl-terminal hydrolase 11
- 26S proteasome regulatory subunit rpn11
- BAG family molecular chaperone regulator 1A
Sequence:
MRDLTSATDSASLESDSSRNQFIINSLLPWYSCSEHEFPHRKARKRRSPKNLDWSVSVQMPLVTSKTKESEKSPKSWSAIAKKHVQGDSPVKKSHSVPVPSDRSEKKSFNSSLGELIETYSPSLDAPRPIQPRGFINTGNICFMNSILQALMYCVPFYNLLKQINRMVPYNFERTTPLIESLTMLSRDFREYSEKFDLQGDSILPEVVYSATKGNPRFEMLQTGEQEDAEEFLNLFLDELHEEFVRERRHYLLKNDERNPKSDIKISNGIKSGLDSFDDQSSVEASGWTEVGKNKKPVIARSATVERSPISQIFGGQLRSTLRVPSARDSVLLEPFQPLQLDIQAEDIHSVIDALEHMTAPEILPEWHSSKGNVTATKQMYIESLPPVLILHLKRFFYEASGGTQKNYKPIAYPARLSIPQNVFSPSVRGSIHPEYDLNAVVYHHGTSASGGHYTVDVQQLDKSGWFRIDDTHIHRVPIHDVENSELSADPSLSKLGHGDRVAYLLFYTRRS