wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase PknK (EC 2.7.11.1) (Protein kinase K) (P9WI65)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Key microbial factor involved in regulation of early and late events in tuberculosis infection, and in host-pathogen interactions. Modulates host immunity during early infection. Slows mycobacterial growth during chronic infection in host and during a variety of stress conditions in vitro. Regulates the expression of a large subset of tRNA genes as a means to facilitate adaptation to changing growth environments. In vitro, directs the inhibition of transcription and translation processes in a phosphorylation-dependent manner. Phosphorylates the transcriptional regulator VirS, thereby increasing the affinity of VirS for the mycobacterial monooxygenase (mymA) promoter. In vitro, can also phosphorylate the mycobacterial monooxygenase operon products Rv3083 (MymA), Rv3084 (LipR), Rv3085 and Rv3088.
Subcellular location: Cytoplasm. Cell membrane. Secreted, cell wall. Note=Probably attached to the cell membrane through interactions mediated by its C-terminal region. May be secreted during infection.
Interaction partners:
- Conserved protein
- Serine/threonine protein phosphatase PstP
- HTH-type transcriptional regulator VirS
- Glycogen accumulation regulator GarA
Sequence:
MTDVDPHATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQPSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLAGGRPFIVMPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEVLEGASPTPASDVYSLGATLFCALTGHAAYERRSGERVIAQFLRITSQPIPDLRKQGLPADVAAAIERAMARHPADRPATAADVGEELRDVQRRNGVSVDEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTGSLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAVAWLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLTSLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSWSRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQALTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDTLEPELREFLLVASVTERTCGGLASALAGITNGRAMLEEAEHRGLFLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWFAENGYLHEAVDHALAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQKLPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFETALGRAELPEATQADLRAEADVLRAVAEVFADRVERVDDLLAEAMSRPDTLPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEMMGPFGTVYAQCLRGMAARNRLDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLAELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHEGAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTIPRDNGIATMTAELDEDSAVRLLSAGDSADRDQACQRAGALAAAIDGTRRPLAALQAQILHIETLAATGRESDARNELAPVATKCAELGLSRLLVDAGLA
Protein: Epididymis luminal protein 164 (V9HWH0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
Protein: uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107) (P95077)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS
Protein: COP-associated protein (Copper ion-binding protein) (Q48271)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Part of a cation-transporting system which is associated with copper export out of the H.pylori cells.
Interaction partners:
- Copper-transporting ATPase
- Copper-transporting ATPase
- Cadmium, zinc and cobalt-transporting ATPase
- Ribosomal protein L11 methyltransferase
- ATP-dependent zinc metalloprotease FtsH
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Chemotaxis protein CheY1
- Uncharacterized protein HP_1070
- Large ribosomal subunit protein uL14
Sequence:
MKATFQVPSITCNHCVDKIEKFVGEIEGVSFIDVSVEKKSVVVEFDAPATQDLIKEALLDAGQEVV
Protein: Terminal uridylyltransferase 1 (TUTase 1) (EC 2.7.7.52) (3' terminal uridylyl transferase) (3' TUTase) (RNA editing terminal uridylyltransferase 1) (RET1) (RNA editing TUTase 1) (Q8WQX6)
Organism: Leishmania tarentolae (Sauroleishmania tarentolae)
Function: Terminal uridylyltransferase which is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA. Specifically, catalyzes the addition of Us to the 3'-hydroxyl group of guided RNA (gRNA), with a preference for RNAs terminating in 6 Us, but also can add Us to RNAs terminating in 6 adenines (A), 6 cytosines (C), or 6 guanines (G). Can mediate RNA-independent UTP polymerization in vitro. Can mediate pyrophosphate-dependent degradation of synthetic RNA ending with U residues in vitro.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11893335}.
Interaction partners:
Sequence:
MSKYSLLFNQGTKDGTNASSGSEANSANITSSSAPASSTNTSSPTSSESAVVSPPASTSPRRRLIHRRHGSAGAAEVAPLSLPKRPQQPNEEKHENFISDSVHHCSNRGASGSELKALTTSGSETVMSASPDIAFEAPSPPTASASPPLESTSAVESDGDVVIDDMMRYQEGDSGGSRSATSAAAAGRAVSTNDAAALINGDPGPLSSAVSSSSSGSPHTPPRLFTCDMCLQYVSTSYEALEQHALDQHGDALADYTRLRSVAEKLVPVWDEVLKRKASVVQQWGKRIFAVAVQRDAGAEKMAEAHRARAQLELVVQRWHPRAKVFIFGSSVAFGVWDGISDIDFTVVDVDELEAGTWPPSEKNAVRSITELLRRAGFSFINLEPISHARVPIIKHHASLPIRLTDEQRHRLYEEARQSAAAVDLVAAESLASSSPSSAQETTDEKGLTQLEAELIIARSVRYSLNLPAGPPDSAILEASIRLAVGSAAVQQVWWNRTRDMCCMTFDTTTNAVKASTCPLHFMSAGMRARVQPLHEECRPELYGMDFDLSFRAFGIRNSHLLRRYLLSHPCARPGALVLKDWSKTSGVNNSVNGYLTSYAINIMWIYYLVHRGVIRYVCPARDIPASLRCNVDADPQYAAMVDPTWTPEERAAMEAQAGELLLGFFYYYAFEFDWVNHVVSLNRPGITTKASLGWDVEDVAQTGSPAPHFGVAGSQHQYNLAGAEGQQGDLHSGTSLSAPQTRPLTGYDGMMASSASAAARRSRATTRYSFCIEDPYEENLNLGRHMGVTKTLRVQTELYRGLLSLLKDDPQHCCVFAGSTNSSGSTDSNGAMASGAAEPAMVAARTPSEPTELPVRVLYKLMAISTRELAIARRRYSATVTAGTEFPGALLSDLEAAFLAQAPTEWKLARQVWNKHQLLHRLGLKLHAREYVLPRREVGVRRLAAKAPPGVVPASAPEPTFTAEEVAAAAAESGQAPFSAEHAPTSSEEVTQMNRAFLGAFPARRLPEDLMLAMTKGYSCLTPSWVAWSKPWAALSAWWTDRLHSPSTTTQGEDPLASGTCEQGGVSPSLPTGAPHHISAVPEKSAGAMHQTRTQLRRHVVAEIASTPAARRVLRLLFR
Protein: Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) (Q9D9V3)
Organism: Mus musculus (Mouse)
Function: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:22016388}.
Interaction partners:
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- Peroxisomal acyl-coenzyme A oxidase 3
- 3-ketoacyl-CoA thiolase, mitochondrial
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Propionyl-CoA carboxylase alpha chain, mitochondrial
- Acyl-CoA synthetase short-chain family member 3, mitochondrial
- Acetyl-coenzyme A synthetase, cytoplasmic
- Methylmalonyl-CoA epimerase, mitochondrial
- Propionyl-CoA carboxylase beta chain, mitochondrial
Sequence:
MRRCEVNSKPISEYFGIPCENREMAKCLLTSSLSVRTKLLQTGVSLYNTSHGFHEEEVKKILEQFPGGSIDLLKKQNGIGILTLNNPNKMNAFSGVMMLQLLERVIELENWTEGKGLIIHGAKNTFCSGSDLNAVKALSTPESGVALSMFMQNTLTRFMRLPLISVALVQGWAMGGGAELTTACDFRLMTEESVIRFVHKEMGIVPSWGGTSRLVEIIGSRQALKVLSGTLKLDSKEALNIGLTDEVLQPSDETTALEQAQEWLEKFVSGPPQVIRGLKKSVCSARELYIEEALQNERDVLETLWGGPANLEAIAKKGKHTK
Protein: BHLH transcription factor 3 (Olig3 protein) (Oligodendrocyte transcription factor 4) (Q5K548)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDSDASSTCSRSSSPDLTVDSGFFSNKMFQAYGETVQQKSEKGLQNAGKTRTRADLSKDDLQDLRLKVNSRERKRMHDLNQAMDGLREVMPYAQGPSVRKLSKISTLLLARNYILMLSSSLEEMKKLVGDVYGANAQSHSARRVLPPTSAAPATQLPLLSLAPSLHPLVGSTSAVSHTTTNGAQTPHSPPSTGYLGFPALPTLLKDPLHLSGGYRHFPGMPCPCSLCQPLPASTASLHSLSMGK
Protein: Homeobox-leucine zipper protein HDG12 (HD-ZIP protein HDG12) (Homeodomain GLABRA 2-like protein 12) (Homeodomain transcription factor HDG12) (Protein HOMEODOMAIN GLABROUS 12) (Q9LMT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that acts as negative regulator of trichome branching in association with HDG11. Seems to promote cell differentiation. May regulate cell differentiation and proliferation during root and shoot meristem development. Acts as positive regulator of SCL18/LAS expression. Involved, together with PDF2, in the regulation of flower organs development by promoting the expression of APETALA 3 (AP3) in the epidermis and internal cell layers of developing flowers.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- At4g14500
- Pleckstrin homology
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- ENHANCED DISEASE RESISTANCE protein
- AT5g54630/MRB17_13
- At3g13062
- C2H2-like zinc finger protein
- Protein ENHANCED DISEASE RESISTANCE 2-like
- Transcription factor bHLH154
Sequence:
MEFLGDSQNHDSSETEKKNKKKKRFHRHTPHQIQRLESTFNECQHPDEKQRNQLSRELGLAPRQIKFWFQNRRTQKKAQHERADNCALKEENDKIRCENIAIREAIKHAICPSCGDSPVNEDSYFDEQKLRIENAQLRDELERVSSIAAKFLGRPISHLPPLLNPMHVSPLELFHTGPSLDFDLLPGSCSSMSVPSLPSQPNLVLSEMDKSLMTNIAVTAMEELLRLLQTNEPLWIKTDGCRDVLNLENYENMFTRSSTSGGKKNNLGMEASRSSGVVFTNAITLVDMLMNSVKLTELFPSIVASSKTLAVISSGLRGNHGDALHLMIEELQVLSPLVTTREFCVLRYCQQIEHGTWAIVNVSYEFPQFISQSRSYRFPSGCLIQDMSNGYSKVTWVEHGEFEEQEPIHEMFKDIVHKGLAFGAERWIATLQRMCERFTNLLEPATSSLDLGGVIPSPEGKRSIMRLAHRMVSNFCLSVGTSNNTRSTVVSGLDEFGIRVTSHKSRHEPNGMVLCAATSFWLPISPQNVFNFLKDERTRPQWDVLSNGNSVQEVAHITNGSNPGNCISVLRGFNASSSQNNMLILQESCIDSSSAALVIYTPVDLPALNIAMSGQDTSYIPILPSGFAISPDGSSKGGGSLITVGFQIMVSGLQPAKLNMESMETVNNLINTTVHQIKTTLNCPSTA
Protein: Zinc finger protein 764 (Q96H86)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:28139699}.
Interaction partners:
Sequence:
MAPPLAPLPPRDPNGAGPEWREPGAVSFADVAVYFCREEWGCLRPAQRALYRDVMRETYGHLSALGIGGNKPALISWVEEEAELWGPAAQDPEVAKCQTQTDPADSRNKKKERQREGTGALEKPDPVAAGSPGLKSPQAPSAGPPYGWEQLSKAPHRGRPSLCAHPPVPRADQRHGCYVCGKSFAWRSTLVEHVYSHTGEKPFHCTDCGKGFGHASSLSKHRAIHRGERPHRCLECGRAFTQRSALTSHLRVHTGEKPYGCADCGRRFSQSSALYQHRRVHSGETPFPCPDCGRAFAYPSDLRRHVRTHTGEKPYPCPDCGRCFRQSSEMAAHRRTHSGEKPYPCPQCGRRFGQKSAVAKHQWVHRPGAGGHRGRVAGRLSVTLTPGHGDLDPPVGFQLYPEIFQECG
Protein: Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) (P00564)
Organism: Rattus norvegicus (Rat)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subcellular location: Cytoplasm.
Interaction partners:
- Creatine kinase B-type
- Guanidinoacetate N-methyltransferase
- Creatine kinase U-type, mitochondrial
- Myosin light chain 1/3, skeletal muscle isoform
- Beta-enolase
- Creatine kinase S-type
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myoglobin
- Ankyrin repeat and SOCS box-containing 9
- Myosin regulatory light chain 11
Sequence:
MPFGNTHNKFKLNYKPQEEYPDLSKHNNHMAKVLTPDLYNKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLANLSKHPKFEEILTRLRLQKRGTGGVDTAAVGAVFDISNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK
Protein: Candida glabrata strain CBS138 chromosome I complete sequence (Q6FR41)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Xylulose kinase
Sequence:
MSSVVTLNNGLKMPLVGLGCWKIPNDVCAQQVYDAIKIGYRLFDGAEDYGNEKEVGQGIRKAIDEGVVKREDVFVVSKLWNSFHHPDHVKMALKRTLSDMGLDYLDLFYIHFPIAFKYVPFEEKYPPGFYTGKEDEKNGHITEAHVPIIDTYRALEQCVEEGLIKSIGISNFSGSLVQDLLRQCKIKPVALQVEHHPYLTQEHLVEYCKDNGIQVVAYSSFGPQSYIELNHPLAKNTPNLFHHDTIKQIANNHNVATSQVLLRWATQRGIAIIPKSSKKERLQDNLMIDEKLTLTHKELEAISKLNKNLRLNDPWDWLDGKFPIFA
Protein: Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2) (Q08230)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDH1 of the SDH catalytic dimer. It is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDH1 in a conformation that is susceptible to autocatalytic FAD attachment. Does not bind FAD or FADH(2) in vitro. Involved in sporulation. Required for the full activation of the early meiotic inducer IME1.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:19628817}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase assembly factor 3, mitochondrial
- Succinate dehydrogenase assembly factor 1, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 2, mitochondrial
- Fumarate reductase 2
- Fumarate reductase 1
- Succinate dehydrogenase cytochrome b subunit
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Mitochondrial FAD carrier protein FLX1
Sequence:
MHNMFPALTKTLSLQGYKIINSQTGSAAWSCGRRWFSSDKDDHDDVVTRIKIAPIKRTNEPLDKKRARLIYQSRKRGILETDLLLSGFAAKYLKKMNEEELEEYDSLLNELDWDIYYWATKNFKTSPLPDKWANSKLLKQLQEFSENKEKEILSMPDLSKYQ
Protein: 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57) (Q9Z0S1)
Organism: Mus musculus (Mouse)
Function: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Interaction partners:
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
- Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
Sequence:
MASSHTVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRLVQMSICSSLARKFPKLTIIGEEDLPPGEVDQELIEDGQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAALGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNQLVTDCISAMNPDTVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNALQYNKEVKHMNSAGVLAALRNYEYYASHVPESVKNALIP
Protein: N-acetylornithine carbamoyltransferase (EC 2.1.3.9) (N-acetyl-L-ornithine transcarbamylase) (AOTCase) (Acetylornithine transcarbamylase) (Q8P8J2)
Organism: Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Function: Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway. The enzyme has no activity with ornithine.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Argininosuccinate synthase
- N-acetyl-gamma-glutamyl-phosphate reductase
- Acetylglutamate kinase
- Argininosuccinate lyase
- Acetylornithine aminotransferase
- N-acetyl-L-citrulline deacetylase
- Carbamoyl phosphate synthase large chain
- Carbamoyl phosphate synthase small chain
- Aspartate carbamoyltransferase catalytic subunit
- L-lysine 6-aminotransferase
Sequence:
MSLKHFLNTQDWSRAELDALLTQAALFKRNKLGSELKGKSIALVFFNPSMRTRTSFELGAFQLGGHAVVLQPGKDAWPIEFNLGTVMDGDTEEHIAEVARVLGRYVDLIGVRAFPKFVDWSKDREDQVLKSFAKYSPVPVINMETITHPCQELAHALALQEHFGTPDLRGKKYVLTWTYHPKPLNTAVANSALTIATRMGMDVTLLCPTPDYILDERYMDWAAQNVAESGGSLQVSHDIDSAYAGADVVYAKSWGALPFFGNWEPEKPIRDQYQHFIVDERKMALTNNGVFSHCLPLRRNVKATDAVMDSPNCIAIDEAENRLHVQKAIMAALVGQSRP
Protein: DNA replication licensing factor MCM2 (EC 3.6.4.12) (Q384N2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM3
- DNA helicase
- DNA replication licensing factor MCM4
- Cell division cycle 45
- DNA replication licensing factor MCM6
- Minichromosome maintenance
- Uncharacterized protein
- Origin recognition complex subunit 1
- GINS subunit domain-containing protein
Sequence:
MPPHRKRRREGDTSRHQGADDVGGREEDDDSERDEEELGEDLFGDNYERDYLHPDEESEVLEDDVEDDDWIDDNSDISVISDSGRLAVDALLDRRNEMEQRLREERRQLEEGVFSDVDKDSIPSTGSDGSGFTAEGSVGGRGAGGDEEDEDVTTTAGNDDGVYVRGELGPMDFDWRQPQCDLVEWLSQELPRHVVKNRIYNFYLNYVENGVCVYEQKVHLMARENEQSFQLSYSHLSRVYDSVLALWLVDVPDVMIELLEDAANYFAFKLFPHYRKVHKHILVRICDLPLCDPIRDFRQIHMNVLVRVEGVVIRRSPVYPQMQAVRYDCVRCSYIIGPIYQRGDKEQRVSLCPSCHSKGPFRVNMTLTEYRNHQTIVLQESPGKVPPGRLPRSLEVILTNDLIDRANPGEEVDVTGIYRNNFDPLLNSRQGFPVFTTLLHANNVVRRTAEVDSFRLPDDERVRIMDLAKHPRVKRKLLRSIAPSIHGREDIKLGLLLGMLGGVPKDVGGDQSHRIRGDINVLLVGDPGCAKSQFLKFVEKTANRAVFTTGRGSTAVGLTASVHRDGVTGDFVLEGGALVIADRGSCLIDEFDKMSDQDRTSIHEAMEQQTISVARGGIVTTLSARCSIVAAANPIGGRYDPSISFDSNVNLTTPILSRFDLLFVVRDEVNVELDEKLATFICHSHIRNHPRTQQESRRSERELQERLSSLRYALENASTEEERRVVEAQLQQLRNSLANEPLNEDEDPSSDKPLPQQLLRKYILYAKAHCHPRVSNIDANTIARLYTELRQESKHGGVAITVRHMESVIRLSEAHARLHLRDFVRDEDVNAAISLFLRCFIQTQKYSLRSAMENRFRKYFDSDTEPLPLIQHHIKVAVHAIRAFERQMSGGVEPTRVRIDVMQLEHCTMNVSKEALNAFFDSEEFKRDYTLIRDPGTGVPLQIEHSLV
Protein: Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1 (EC 3.1.-.-) (Q94K49)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transposase-derived protein that may have nuclease activity (Probable). Antagonist of polycomb-group (PcG) protein-mediated chromatin silencing, probably by preventing the association of POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) with its accessory components. Needed for full reactivation of several floral homeotic genes that are repressed by PcG.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:26642436}.
Interaction partners:
- PWWP domain-containing protein 2
- PWWP domain-containing protein 3
- WD-40 repeat-containing protein MSI5
- PWWP domain-containing protein 1
- VIN3-like protein 2
- WD-40 repeat-containing protein MSI4
- Staphylococcal-like nuclease CAN1
- Probable polyamine transporter At3g13620
- PWWP domain-containing protein 5
- ADP-ribosylation factor-like protein 2
Sequence:
MAPVKQKKKNKKKPLDKAKKLAKNKEKKRVNAVPLDPEAIDCDWWDTFWLRNSSPSVPSDEDYAFKHFFRASKTTFSYICSLVREDLISRPPSGLINIEGRLLSVEKQVAIALRRLASGDSQVSVGAAFGVGQSTVSQVTWRFIEALEERAKHHLRWPDSDRIEEIKSKFEEMYGLPNCCGAIDTTHIIMTLPAVQASDDWCDQEKNYSMFLQGVFDHEMRFLNMVTGWPGGMTVSKLLKFSGFFKLCENAQILDGNPKTLSQGAQIREYVVGGISYPLLPWLITPHDSDHPSDSMVAFNERHEKVRSVAATAFQQLKGSWRILSKVMWRPDRRKLPSIILVCCLLHNIIIDCGDYLQEDVPLSGHHDSGYADRYCKQTEPLGSELRGCLTEHLLR
Protein: Peroxygenase (EC 1.11.2.3) (Caleosin) (SiCLO) (Q9SQ57)
Organism: Sesamum indicum (Oriental sesame) (Sesamum orientale)
Function: Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies. May be involved in the interaction between oil bodies and vacuoles during seed germination (By similarity).
Subcellular location: Lipid droplet {ECO:0000269|PubMed:10589521, ECO:0000269|PubMed:18632804, ECO:0000269|PubMed:9816677}. Microsome membrane {ECO:0000269|PubMed:10589521}.
Interaction partners:
Sequence:
MATHVLAAAAERNAALAPDAPLAPVTMERPVRTDLETSIPKPYMARGLVAPDMDHPNGTPGHVHDNLSVLQQHCAFFDQDDNGIIYPWETYSGLRQIGFNVIASLIMAIVINVALSYPTLPGWIPSPFFPIYLYNIHKAKHGSDSGTYDTEGRYLPMNFENLFSKHARTMPDRLTLGELWSMTEANREAFDIFGWIASKMEWTLLYILARDQDGFLSKEAIRRCYDGSLFEYCAKMQRGAEDKMK
Protein: Ovarian cancer G-protein coupled receptor 1 (G-protein coupled receptor 68) (Sphingosylphosphorylcholine receptor) (Q8BFQ3)
Organism: Mus musculus (Mouse)
Function: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MGNITTENSSLSCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDDWSHGDLSCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHKEVIEDEDQHRVCFEHYPIQAWQRSINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWERNCEFAKSIFNVYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPSSLGVGGPSTVGLA
Protein: Occludin (Q9PUN1)
Organism: Xenopus laevis (African clawed frog)
Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q16625}; Multi-pass membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q16625}.
Interaction partners:
Sequence:
MYSRPSNYAPSKDVYGGEMRSQPAYSYYPEEEIQHFYRWSSPPGIIKIMSILIVVMCVGIFACVASTLPWDLDITGQSMGYGMGSGSYSGGYTGYGFGGSQMGLGFAYGGNYTDPRAAKGFILAMAAFCFIIGLVIFVMLVTRTPLSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVAQASGSAFYTQIVSICNQFYSPVQTGVFVNQYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFFAVKTRKKINQYGKTNILWKKNHIYEDGDPQVEQWVKNVAENSAPALSDYNEKVDGSVADYRSANGVQAYPSQNNISHPIAEEELPLKEDYGMSPRHYSSSSDATTKKAPPKKRPGKPRRSDLDTNEGGYNTGGESADELEDDSWDSEYPPITQTKQRQEYKQEFASDLHEYKRLQAELDELSKIPVPSLNRELGQSSRKDSEEYRTVADKYNRLKEIKSSADYRNKKKRCKGLKTKLNHIKQMVSNYDK
Protein: Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) (Q6ZN28)
Organism: Homo sapiens (Human)
Function: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19098908}. Nucleus {ECO:0000269|PubMed:19098908}. Note=Mainly found in the cytoplasm in non-metastasizing tumors.
Interaction partners:
- Hepatocyte growth factor
- Hepatocyte growth factor receptor
Sequence:
MLITERKHFRSGRIAQSMSEANLIDMEAGKLSKSCNITECQDPDLLHNWPDAFTLRGNNASKVANPFWNQLSASNPFLDDITQLRNNRKRNNISILKEDPFLFCREIENGNSFDSSGDELDVHQLLRQTSSRNSGRSKSVSELLDILDDTAHAHQSIHNSDQILLHDLEWLKNDREAYKMAWLSQRQLARSCLDLNTISQSPGWAQTQLAEVTIACKVNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPHMLNHDLSCTVSPLLEIMLGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPFKVLSNCYIYKDTIQVKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSFTVVLTVCGHNYMPGQLTISDIKKGGKNISPVVFQLWGKQSFLLDKPQDLSISIFSCDPDFEVKTEGERKEIKQKQLEAGEVVHQQFLFSLVEHREMHLFDFCVQVEPPNGEPVAQFSITTPDPTPNLKRLSNLPGYLQKKEEIKSAPLSPKILVKYPTFQDKTLNFSNYGVTLKAVLRQSKIDYFLEYFKGDTIALLGEGKVKAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMFMSDSVFTTRNLLEQIVLPLKKLTYIYSVVLTLVSEKVYDWKVLADVLGYSHLSLEDFDQIQADKESEKVSYVIKKLKEDCHTERNTRKFLYELIVALLKMDCQELVARLIQEAAVLTSAVKLGKGWRELAEKLVRLTKQQMEAYEIPHRGNTGDVAVEMMWKPAYDFLYTWSAHYGNNYRDVLQDLQSALDRMKNPVTKHWRELTGVLILVNSLEVLRVTAFSTSEEV