wanglab/gogpt-training-data huggingface dataset:
Protein: DNA topoisomerase 3 (EC 5.6.2.1) (DNA topoisomerase III) (O60126)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
Interaction partners:
- ATP-dependent DNA helicase hus2/rqh1
- RecQ-mediated genome instability protein 1
- Crossover junction endonuclease mus81
- DNA repair protein rhp51
- Replication factor A protein 1
- ATP-dependent DNA helicase srs2
- DNA replication ATP-dependent helicase/nuclease dna2
- Exodeoxyribonuclease 1
- DNA repair protein rhp54
- DNA repair and recombination protein rad22
Sequence:
MRVLCVAEKNSIAKSVASILGGGHVRRRDTRSKYVKNYDFSFNFGGNVGSSDVTMTSVSGHLTEASFPSEYSSWSSVPQDVLFDAQIITSVSKNAEVLADNIKKEARNAQYLYIWTDCDREGEHIGVEISNVARASNPSIQVIRADFNNLERSHIISAAKRPRDVSKNAADAVDARIELDFRLGAIFTRLQTIQLQKSFDILQNKIISYGPCQFPTLGFVVDRWQRVEDFVPETYWHLRFVDKRQGKTIQFNWERAKVFDRLTTMIILENCLECKTAKVVNITQKPKTKYKPLPLSTVELTKLGPKHLRISAKKTLELAENLYTNGFVSYPRTETDQFDSSMNLHAIIQKLTGAQEWDSYAEGLLAGDYRPPRKGKHNDRAHPPIHPVQMVHRSALPSQDHWKVYELITRRFLACCSDNAKGAETLVQVKMEEELFSKKGLLVTEKNYLEVYPYEKWESSDQLPEYRLHEEFQPHILDMMDSSTSSPSYITEPELIALMDANGIGTDATMAEHIEKVQEREYVIKRKKRGQGVTEFVPSSLGVALAKGYDEIGLEWSLTKPFLRKEMEVQLKNIENGQLNRNVLVHMILTQFRDVFHLTKQRFDCLKNSCRVYLMSHNEPQT
Protein: Inactive serine/threonine-protein kinase 19 (Protein G11) (Protein RP1) (P49842)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors.
Subcellular location: [Isoform 3]: Nucleus {ECO:0000269|PubMed:32531245}. Note=Very tightly chromatin-associated. {ECO:0000269|PubMed:32531245}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:32531246, ECO:0000269|PubMed:9812991}. Cytoplasm {ECO:0000269|PubMed:32531246}.
Interaction partners:
- Superkiller complex protein 2
- Tenascin-X
- Complement C4-A
- Steroid 21-hydroxylase
- Decapping and exoribonuclease protein
Sequence:
MSWKRHHLIPETFGVKRRRKRGPVESDPLRGEPGSARAAVSELMQLFPRGLFEDALPPIVLRSQVYSLVPDRTVADRQLKELQEQGEIRIVQLGFDLDAHGIIFTEDYRTRVLKACDGRPYAGAVQKFLASVLPACGDLSFQQDQMTQTFGFRDSEITHLVNAGVLTVRDAGSWWLAVPGAGRFIKYFVKGRQAVLSMVRKAKYRELLLSELLGRRAPVVVRLGLTYHVHDLIGAQLVDCISTTSGTLLRLPET
Protein: Chemotaxis protein PomA (O06873)
Organism: Vibrio alginolyticus
Function: PomA and PomB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity).
Subcellular location: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Flagellar motor protein MotB
- Flagellar motor switch protein FliG
- Flagellar basal-body rod protein FlgC
- Flagellar motor switch protein FliN
- Flagellar motor switch protein FliM
- Type VI secretion system protein TssL
- Flagellar motor switch protein FliN
- Flagellar motor switch protein FliG
- Flagellar hook-associated protein FlgK
- Flagellar basal-body rod protein FlgG
Sequence:
MDLATLLGLIGGFAFVIMAMVLGGSIGMFVDVTSILIVVGGSIFVVLMKFTMGQFFGATKIAGKAFMFKADEPEDLIAKIVEMADAARKGGFLALEEMEINNTFMQKGIDLLVDGHDADVVRAALKKDIALTDERHTQGTGVFRAFGDVAPAMGMIGTLVGLVAMLSNMDDPKAIGPAMAVALLTTLYGAILSNMVFFPIADKLSLRRDQETLNRRLIMDGVLAIQDGQNPRVIDSYLKNYLNEGKRALEIDE
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 1 (O76388)
Organism: Caenorhabditis elegans
Interaction partners:
- Synaptonemal complex protein 3
- HORMA domain-containing protein
- HORMA domain-containing protein
- Synaptonemal complex protein 4
- Meiotic recombination protein spo-11
- HORMA domain-containing protein
- HORMA domain-containing protein
- Long arms of the bivalent protein 1
- Cyclin N-terminal domain-containing protein
- Zip homologous protein 3
Sequence:
MNSAHRSSLKKRPGPQDDRRVSFASPVSSSQKTAAVTVAAQTKQPAKAKNLRTMHSTPKKSKPAHDVADIISLVSKQSDILDDVSEIEHKMIKQAKMTQDLTMELANSIERIANMALAESKLSDQMEKQSKKLISLEGKTKELVEKANNWSKTLENRVDARSHHSTCLNDVQAAIKIINNAKINNDGFSEDFSAHYDKLLDLVETLEPWADKL
Protein: Uncharacterized protein C12C2.01c (Q09742)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MYNVTYRLLRLSLISSHSLRKSRSFDVKNFANIHFFIPLPNTPKKFYSVNAFSPLLKARRMTATIVSNHNVGCSCCYFRQYSTKQFRDLNTSEALSPCKAEPIPYKIMSSMSNFSDFKSRFSQYRESHLKLLNELQNVKDTNDLKDRIRLLHLNSSSKLNAFLHDLINAPNVSAEMKENCVRLIFFGRKYDPFLRSRMFTLTIRYFLLQKNRLRTSFYLLKHMELLALPASYELKTTLLEWFLRKRKFETAQKIFLSLCFSQHFPSEKLLMVLLLHGTETMQEYAMIQAINFVNTEQKLRFYDRLHSICSKLKFSSTG
Protein: DNA polymerase epsilon subunit 3 (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) (NF-YB-like protein) (YB-like protein 1) (YBL1) (Q9JKP7)
Organism: Mus musculus (Mouse)
Function: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA polymerase epsilon subunit 4
- DNA polymerase epsilon subunit 2
- DNA polymerase epsilon catalytic subunit A
- Chromatin accessibility complex protein 1
- Bromodomain adjacent to zinc finger domain protein 1A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Protein Dr1
- DNA polymerase delta catalytic subunit
- DNA polymerase alpha catalytic subunit
- DNA polymerase delta subunit 2
Sequence:
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFITPLKEALEAYRRDEKGKKEASEQKKKDKDKKDSEEQDKSREVEEEDEERLDEDDQNEEEEIDN
Protein: Coronin-like protein crn1 (O13923)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Cofilin
- Actin
- Fimbrin
- Actin-binding protein wsp1
- Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
- Riboflavin synthase
- Protein app1
- Actin-related protein 2
- Endocytosis protein end4
- Myosin-1
Sequence:
MSGRFVRASKYRHIFGQTCKKELCYDNIKLSNNAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLNERGKLPDQVNLFRGHTAAVLDTDWNPFHDQVLASGGDDSKIMIWKVPEDYTVMEPYEDVHPIAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKGVAHVSLKMDVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNPRVVWLGSLDRFATTGFSKMSDRQIALWDPTNLSEPIGGFTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEYENDVFHYLSEFKSVDPQRGIAFLPKRGVNVSENEVMRAYKSVNDSIIEPISFIVPRRSESFQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQKEETVTQPKREKTPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKVEEKEPFYVSKDKKDISAVNLADLNKRFEGFEKRYEEELAIRDWKIAQLEDKLAKLTEAIKEKCN
Protein: Radical S-adenosyl methionine domain containing 2 (C9J674)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCAINGRRSGADAWPRGPRCAAPRACAVPRRRLPGLTPNEAPRRRPQGMEKINFSGGEPFLQDRGEYLGKLVRFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISCDSFDEEVNVLIGRGQGKKNHVENLQKLRRWCRDYRVAFKINSVINRFNVEEDMTEQIKALNPVRWKVFQCLLIEGENCGEDALREAERFVIGDEEFERFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYIWSKADLKLDW
Protein: RNA polymerase II-associated protein 1 homolog (Q9US06)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C13E7.08c
- RNA polymerase-associated protein C651.09c
- Cell division control protein 73
- Tetratricopeptide repeat protein 1
- FACT complex subunit pob3
- FACT complex subunit spt16
- Meiotic recombination protein rec14
- Transcription elongation factor spt5
- DNA-directed RNA polymerase II subunit rpb1
- Transcription elongation factor spt4
Sequence:
MENRRQDYILRVRYHNPLPPPPFPPKLINIPNPVKQYALPNFVSTLVQEKKIPIENDIELGMPLDLAGITGFFEGDTSWMHSDLSSVNLDPIDRSLLKVAGGSGSTHLEVPFLRRTEYISSEVARAASNRGNLRLTASTSKALAEQRGRSLREVPKQLEAINESFDVVQQPLEQLKHPTKPDLKPVSAWNLLPNTSMAGIQHLMLRVADDLSERSHSYSSLVNLQEGHNLTKRHEVALFMPSSAEGEEFLSYYLPSEETAEEIQAKVNDASADVHEPFVYNHFRNFDASMHVNSTGLEDLCLTFHTDKDHPEANQVLYTPIYARSTLKRRHVRAPVSLDAVDGIELSLRDLNDEESLQLKRARYDTFGLGNIKDLEEEEEKLRSVEGSLNEELSEEEKPAESREQLESAEQTNGVKPETQAQNMSASESQANSPAPPVEEGNTQPSPVEQLQNEED
Protein: Mitochondrial carrier protein Rim2 (Q9VQ37)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24469456}. Mitochondrion inner membrane {ECO:0000305|PubMed:24469456}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAQNTADTLIHLIAGGSAGTVGAVVTCPLEVVKTRLQSSTAFMTPSRLAENAGGGPANGGQSELLRPEQRRKLSTTILRNRSQPQVIGGVRRIMAISHCGISSTTPKSMSIVQCLRHIVQNEGPRALFKGLGPNLVGVAPSRAIYFCTYSQTKNTLNSLGFVERDSPLVHIMSAASAGFVSSTATNPIWFVKTRMQLDYNSKVQMTVRQCIERVYAQGGVAAFYKGITASYFGICETMVHFVIYEFIKSKLLEQRNQRHTDTKGSRDFLEFMMAGAVSKTIASCIAYPHEVARTRLREEGNKYNSFWQTLHTVWKEEGRAGLYRGLATQLVRQIPNTAIMMATYEAVVYVLTRRFNNKSNEFYDF
Protein: Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) (Q96HI0)
Organism: Homo sapiens (Human)
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}.
Interaction partners:
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 1
- Nucleophosmin
- Nucleolar GTP-binding protein 2
- Large ribosomal subunit protein eL43
- SUMO-activating enzyme subunit 1
- SUMO-conjugating enzyme UBC9
- Ran GTPase-activating protein 1
- Small ubiquitin-related modifier 4
- SUMO-activating enzyme subunit 2
Sequence:
MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPVTWNRQLRHFQGRKKALQIQKTWIKDEPLCAKTKFNVATQNVSTLSSKVKRKDAKHFISSSKTLLRLQAEKLLSSAKNSDHEYCREKNLLKAVTDFPSNSALGQANGHRPRTDPQPSDFPMKFNGESQSPGESGTIVVTLNNHKRKGFCYGCCQGPEHHRNGGPLIPKKFQLNQHRRIKLSPLMMYEKLSMIRFRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQETRRENGEGGSCSPFPSPEPKDPSCRHQPYFPDMDSSAVVKGTNSHVPDCHTKGSSFLGKELSLDEAFPDQQNGSATNAWDQSSCSSPKWECTELIHDIPLPEHRSNTMFISETEREIMTLGQENQTSSVSDDRVKLSVSGADTSVSSVDGPVSQKAVQNENSYQMEEDGSLKQSILSSELLDHPYCKSPLEAPLVCSGLKLENQVGGGKNSQKASPVDDEQLSVCLSGFLDEVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLMD
Protein: Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2) (Q6UXL0)
Organism: Homo sapiens (Human)
Function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Interleukin-22 receptor subunit alpha-1
- Interleukin-24
- Interleukin-20 receptor subunit alpha
- Interleukin-19
- Interleukin-20
- Interleukin-10 receptor subunit alpha
- Interleukin-22
- Interleukin-26
- Interferon lambda-1
- Interferon lambda-3
Sequence:
MQTFTMVLEEIWTSLFMWFFYALIPCLLTDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQGEYESLYTSHIWIPSSWCSLTEGPECDVTDDITATVPYNLRVRATLGSQTSAWSILKHPFNRNSTILTRPGMEITKDGFHLVIELEDLGPQFEFLVAYWRREPGAEEHVKMVRSGGIPVHLETMEPGAAYCVKAQTFVKAIGRYSAFSQTECVEVQGEAIPLVLALFAFVGFMLILVVVPLFVWKMGRLLQYSCCPVVVLPDTLKITNSPQKLISCRREEVDACATAVMSPEELLRAWIS
Protein: Pro-secreted protein ORF2 (Protein ORF2) (pORF2) [Cleaved into: Secreted protein ORF2 (ORF2s)] (Q81871)
Organism: Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV)
Function: Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.
Subcellular location: [Isoform Secreted protein ORF2]: Secreted {ECO:0000250|UniProtKB:Q9YLQ9}. Note=Cotranslationally translocated into the ER (By similarity). Translation from the first AUG produces a full-length protein with a signal peptide that can direct the protein into the secretory pathway (By similarity). {ECO:0000250|UniProtKB:Q68985, ECO:0000250|UniProtKB:Q9YLQ9}.; SUBCELLULAR LOCATION: [Isoform Capsid protein]: Virion {ECO:0000269|PubMed:35055972}. Host cytoplasm {ECO:0000269|PubMed:31000788}. Host endoplasmic reticulum {ECO:0000269|PubMed:27899274}. Host Golgi apparatus {ECO:0000269|PubMed:27899274}. Host cell surface {ECO:0000250|UniProtKB:Q68985}. Host nucleus {ECO:0000269|PubMed:31000788}. Note=Translation from the internal AUG codon disrupts the signal sequence, producing a cytoplasmic protein that is responsible for virion assembly (By similarity). Shuttles between cytoplasm and nucleus (By similarity). This isoform is found in quasi-enveloped virions (PubMed:35055972). {ECO:0000250|UniProtKB:P33426, ECO:0000250|UniProtKB:Q9YLQ9, ECO:0000269|PubMed:35055972}.
Interaction partners:
Sequence:
MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRADSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASEHVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSLVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTTQQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTMDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL
Protein: GTPase-activating protein GYP6 (GAP for YPT6) (P32806)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stimulates specifically the GTPase activity of YPT6.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- GTP-binding protein YPT6
- GTP-binding protein YPT32/YPT11
- GTPase-activating protein GYP1
- GTPase-activating protein GYP8
- Vacuolar protein sorting-associated protein 35
- Carboxypeptidase Y-deficient protein 8
- GTPase-activating protein GYP7
- GTPase-activating protein GYP2
- GTPase-activating protein GYP5
Sequence:
MKDVLQWAIDHYETRDQLVQKGIWKGELYHDSIFKENSRGWLWKALLLCDENNNCLLTDNFKGLDLNQFGLVPVPMLADGDNYDENHNANVPKRVLHSNVSSSVGIRRLTPVEAVEKHPLSDDNDKTKGSLSKGSDEKPLTLRETLEIIDLDLSRIMLDDIFQEPKVHAQMRQLLYNYLLIHQSEHLQYKQGFHEILSVIYLQLYHGTDLDNTDLQNVLIIFNKLMNQIEPIFYNEENLINWDKRVFTKIFRICLPDLFSKVFYQPPKTGSGKKKNVDHLIHSNLIWLIRWTRLLFLRELPLKYVLIVWDHVLTFNYPLDIFIACTIITLLLSIYDELHELVSQGDYEHTNNNDEFVELILHFKKIFEKEDASKDDEKFLDLCKVTGNLCELWYGKNYDDMRLICDTFINAKFGIKTSDVLSMETAKLTIDPNRQSLENKLRERVRQTILKNKKKISQ
Protein: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT) (O76156)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.
Subcellular location: Mitosome {ECO:0000269|PubMed:19995967}.
Interaction partners:
Sequence:
MSIQENLNNLIKPHGGKLIKTLKYGAERDECIKEAKSLPKIDISSREFGDLVMMGIGGFSPLNGFMKKEDWFSVCKNFTLADGTFWPIPITMSVSEEEAKKLKRGQKVALKYNKDINDISGTIEIDQVYEMTKKDKEMECKDIFTTTDSDHPGVKKVMEQKPFNVAGKVTTLSEGEFPIKYKGIYMTPEESRLNFAKKGWKTIAALQLRNPMHRSHEFLAKIAVEVCDGVFIHSLVGNLKPGDIPAEVRVKCIDALVDKYFVKKNVLQGGYPLDMRYGGPREALLHATFRQNYGCTHMIIGRDHAGVGDYYGPFDAQKIFDKIPYNADPKKRLLTQPMKIDWTFYCHKCDGMASLRTCPHTKKDRVIVSGTMVRKMLSEGKTLPDHFGRAESLKILADYYQHLDKSKKVTIKLQKFATGDAMK
Protein: Signal transduction histidine-protein kinase/phosphatase MprB (EC 2.7.13.3) (EC 3.1.3.-) (Mycobacterial persistence regulator B) (P9WGL1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA. MprB/MprA is involved in regulation of numerous stress-responsive genes, including up-regulation of two sigma factors, sigE and sigB as well as pepD and mprA, and repression of multiple genes from regulons associated with hypoxia, starvation and iron metabolism. The majority of genes regulated by MprB/MprA under a particular stress condition are different from those induced during normal growth, but several genes are commonly regulated under more than one condition.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Response regulator MprA
- Serine protease PepD
- Transcriptional regulatory protein PrrA
- Transcriptional regulatory protein TcrA
- Transcriptional regulatory protein TrcR
- DNA-binding response regulator MtrA
- Probable transcriptional regulatory protein TcrX
- Sensory transduction protein RegX3
- Possible two component system response transcriptional positive regulator PhoP
- Transcriptional regulatory protein KdpE
Sequence:
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT
Protein: Possible penicillin-binding lipoprotein (O33346)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- PASTA domain-containing protein
- Carboxypeptidase Rv3627c
- Penicillin-binding protein 1A
- Cell division protein FtsQ
- D-alanyl-D-alanine carboxypeptidase DacB1
- Secreted protein P60-related protein
- Beta lactamase like protein
- Probable peptidoglycan glycosyltransferase FtsW
- Peptidoglycan glycosyltransferase RodA
- D-alanyl-D-alanine carboxypeptidase DacB2
Sequence:
MVTKTTLASATSGLLLLAVVAMSGCTPRPQGPGPAAEKFFAALAIGDTASAAQLSDNPNEAREALNAAWAGLQAAHLDAQVLSAKYAEDTGTVAYRFSWHLPKDRIWTYDGQLKMARDEGRWHVRWTTSGLHPKLGEHQTFALRADPPRRASVNEVGGTDVLVPGYLYHYSLDAGQAGRELFGTAHAVVGALHPFDDTLNDPQLLAEQASSSTQPLDLVTLHADDSNRVAAAIGQLPGVVITPQAELLPTDKHFAPAVLNDVKKAVVDELDGKAGWRVVSVNQNGVDVSVLHEVAPSPASSVSITLDRVVQNAAQHAVNTRGGKAMIVVIKPSTGEILAIAQNAGADADGPVATTGLYPPGSTFKMITAGAAVERDLATPETLLGCPGEIDIGHRTIPNYGGFDLGVVPMSRAFASSCNTTFAELSSRLPPRGLTQAARRYGIGLDYQVDGITTVTGSVPPTVDLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIAGRPTAVEGDATPISQKMIDALRPMMRLVVTNGTAKEIAGCGEVFGKTGEAEFPGGSHSWFAGYRGDLAFASLIVGGGSSEYAVRMTKVMFESLPPGYLA
Protein: Combover, isoform D (M9PFE5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAPPPKVVVDQANASARSNGSSNNNSVGGATGAVPKQQTPVNGAPTSGSSASVTSSRSARSRRQQEHLGEPDMELVEPETLQRETLKTLNDLLQRARITNAKNRSPAEQHLSSKDHRSPAQQQQQREALRQLAAEHGNYDTAEQLQEQQQRYRFPVRPVQRVQHQPSSSANSTGAPSSSTALLRLRQSTPPNATVGVVIPNATTSNGNGNLSGNEEQAPPLTPAGLQQLVHRLLGVHHFAPRTEGFRSQVDVLRALLGLDENLNSRYQPSRKVVETNNMVHEINPNSDQGEGVVNSTSLEDVALSEMSDNRAQSIQSLHSVLETPTPDTTPSFDELQQRLEASNRNMQHLHDEQAKLLQIQNLAKTHLNEMERLRQQADSLPHNVNGGEAPKYESVQQVQDDMASLVGRMKNLTAFIHNQNELSTVLGDDGPEILAEQEALQEKLESLRTQREDMRNLVDELNSINRAARETARVIKEKEETPTPPPKPEEAAPAAPKERVVPVEYQRNVPIIRQEAANAAQRALHAQAMINQKTADIEALKAQMARLKGMLYTVSQIEESTPSMGSTLERRSEERTSVERELPAEIAQRVFALNDVTSELRAEAASLQKERDRILALKAEIERRKQQAAAAVQMGDDALKRSSLTPTPTPMRQRMTEEEDPSEVDNSLQATPTKEQLRDELRSQCERLRTEYEQKQRELEQRYVASNNTTSEADDEANDDTDSDKYFANAPPPPPPAPPSTLNEDDLNVTLDTLSLGNDSIPSSSNRSQYMPPPMQPVPGMWASHNSGSSWHGQQPVYGQPSSSAGTEFKKLPAAQQGGSSNGSGSNASTDAVLLQQFMQTQQMLINSVCQCNQALWHQQREIDNLNHQLHALQDRFNVVACQDHSFGLRSESVPPPVGPGMGQMPNNLCLGSSRAQSEQLFNFGAHQSAFSNYQRSCHRSGAESHHHQQQQHQAQPFLNNAAPPPPPTHFNNETPLSPPTYRSSPGPIFMNHHNNTIHQNNSNLRTQNQHANNLHSLPEGAAGGGAPGGGITLNNQVPPGNRANNYWDNFRSHSRQNLLSNKSNEELNVDLQQYRRQRARPSYFQPPQLLPPTTRGGLTHQQQRRHFFEAPLTALHGSSSNGSNNLNNSGSSGRKRDWRDDAGHIRDHDDEDVDEVEENHDNVIFGSGRRRNRRRPQLSTLRDDESEQASSSNLNMNVNYGNSPLYQRNKVPAKPTTSTVSLTPLQQRHLRFDFELPAHYMDYIELPQITPVDTTPTLGQEASPADESNAMEQTEETASEELNRNLLVNALKNDKFTTKFYESIKEDVYRRLETLFEQQQQQQQQQQQQNQQLQHSHEPHGLRKALNQEENEPTGDAEATESRSETPLEVMRLQLDNDRPEDEKGTPVKQLSLSNPQNGQHLDEMEDSASAVISSLRTENEEQILEGKLEQASGSGSGPGTSIELAPDHELIEYIIKRIRNQTHNNTVINDSLLAEVSKLTATAAQNSTASSPLISPKRIYAKIKKMDIPRQRDEFLLWYRSYLEQLFVVEQPQDSCKTKSKVTPSGASPAKLKNQRVRKQSQSQSQDSNNDADLAEADQKNVSSAGNGELECENNENPDEEADGQAAAEPSGAEKQDVSLE
Protein: Dynamin-related protein 5A (Protein ARC5-like) (F4HPR5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable microtubule-associated force-producing protein that is targeted to the forming cell plate during cytokinesis. May play a role in cell division.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18809930}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18809930}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:18809930}. Note=Localizes in the forming cell plate during cytokinesis.
Interaction partners:
- Probable transmembrane GTPase FZO-like, chloroplastic
- Dynamin
- Ikzf5
Sequence:
MANSNTYLTTPTKTPSSRRNQQSQSKMQSHSKDPINAESRSRFEAYNRLQAAAVAFGEKLPIPEIVAIGGQSDGKSSLLEALLGFRFNVREVEMGTRRPLILQMVHDLSALEPRCRFQDEDSEEYGSPIVSATAVADVIRSRTEALLKKTKTAVSPKPIVMRAEYAHCPNLTIIDTPGFVLKAKKGEPETTPDEILSMVKSLASPPHRILLFLQQSSVEWCSSLWLDAVREIDSSFRRTIVVVSKFDNRLKEFSDRGEVDRYLSASGYLGENTRPYFVALPKDRSTISNDEFRRQISQVDTEVIRHLREGVKGGFDEEKFRSCIGFGSLRDFLESELQKRYKEAAPATLALLEERCSEVTDDMLRMDMKIQATSDVAHLRKAAMLYTASISNHVGALIDGAANPAPEQWGKTTEEERGESGIGSWPGVSVDIKPPNAVLKLYGGAAFERVIHEFRCAAYSIECPPVSREKVANILLAHAGRGGGRGVTEASAEIARTAARSWLAPLLDTACDRLAFVLGSLFEIALERNLNQNSEYEKKTENMDGYVGFHAAVRNCYSRFVKNLAKQCKQLVRHHLDSVTSPYSMACYENNYHQGGAFGAYNKFNQASPNSFCFELSDTSRDEPMKDQENIPPEKNNGQETTPGKGGESHITVPETPSPDQPCEIVYGLVKKEIGNGPDGVGARKRMARMVGNRNIEPFRVQNGGLMFANADNGMKSSSAYSEICSSAAQHFARIREVLVERSVTSTLNSGFLTPCRDRLVVALGLDLFAVNDDKFMDMFVAPGAIVVLQNERQQLQKRQKILQSCLTEFKTVARSL