wanglab/gogpt-training-data huggingface dataset:
Protein: SPerm CHromatin enriched (P91497)
Organism: Caenorhabditis elegans
Interaction partners:
- Sperm-specific class P protein 16
- MS Related Protein
- BAR domain-containing protein
- MS Related Protein
- Major sperm protein
- PH domain-containing protein
- PDZ domain-containing protein
- PDZ domain-containing protein
- Sperm-Specific family, class Q
- Nematode Specific Peptide family
Sequence:
MPKSKSQKNKLRPRDSKGRFTPLAKAKRTVVSRSRSRSRSASRGARQSRSVGRPMSRRNSVRSISTHTAKSPSLVLVISGSPSPRRRRPSTRRSSSRRSVVRSVSRGSKGRRSSSRGSVYGRTGRSRSSKRSRSRSRPRTRSGSRSSSRSRSGSRRSSRRRSRHRSSSKARGRRASTAKKTPAKRRSRSRSQQKVKRSMSRKG
Protein: F21O3.6 protein (Sulfate/thiosulfate import ATP-binding protein, putative (DUF506)) (Q9SRT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g25400
- O-fucosyltransferase 20
- Poly polymerase
- Nematode resistance protein-like HSPRO2
- BTB/POZ and TAZ domain-containing protein 5
- Ethylene-responsive transcription factor ERF012
Sequence:
MGFSRAKRVTDPLAEEVRARLVGCSFSSGSEHTGDGIEDYEDDDSPCLSDLVQGFLEDEVDTVDDESCWCDQDSGSDSDSDSELGELPDFADDIAKLLRNSLREDSYGRTVLVHVARAMEMLSSLGSQPEQRAVFQRKVMSLLRELGHNAAICKTKWKSSGGLTAGNHEFIDVVYTPSASSQSVRFIVDLDFSSRFQIARPTSQYARVLQSLPAVFVGKGDDLKRILRLVCDAARISLRNRGLTLPPWRKNRYMQTRWLGPYKRTTNLTPSTSGVDTVMCRAIGFDNAVGGRLFVRTR
Protein: Paired box protein Pax-9 (Q98865)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Muscle segment homeobox 1a.
- Homeobox protein Nkx-3.2
- Homeobox protein BarH-like 1
- Ectodysplasin A receptor
- Ectodysplasin-A receptor-associated adapter protein
Sequence:
MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISRILRNKIGNLSQQNQYESSKQASHPQPQPTIPYNHLYSYPTPIAAAGTKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILGIRSITEQQISDNPSFPSAKLEEWRAINRSNFSPANSPLVNGVDKPHLEPEAKYNQTPNGLPTVNSYVTAPSIHHYHPPTQVSPYMGYSGTTSAYVTGPTWQPPSGSALSPHSCDISSPLAFKSMSATRDSVHSLVASAL
Protein: Twist-related protein 2 (P97831)
Organism: Rattus norvegicus (Rat)
Function: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues (By similarity). {ECO:0000250}.
Interaction partners:
- CD44 antigen
- Twist-related protein 1
- Snail homolog 1
- Zinc finger protein SNAI2
- Transcription factor E2-alpha
Sequence:
MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
Protein: Probable histidinol-phosphatase (HolPase) (EC 3.1.3.15) (O14059)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Histidinol-phosphate aminotransferase
- Histidinol dehydrogenase
- Histidine biosynthesis bifunctional protein his7
- Imidazole glycerol phosphate synthase hisHF
- ATP-dependent helicase rhp16
- Imidazoleglycerol-phosphate dehydratase
Sequence:
MPISSHSHSGQFCLHAQGKLEDVIQEAIQQGFQSFSFTEHTPRDRVEDLYPEELHLQPEDLFKTFDEYVNEARRLKQNYGDQINILIGAETEYIRPESVELLKSLNTKYNLDYFVGSVHHVNSIPIDFSPELWQKALQHVGNNPEQLFIDYFEHQYDLMQRLHPLVIGHFDLICLFAPEDAKEVFKNSKSVWELIQRNIKYAVSYGGIFEINTSAFRKGWKTAYPQQRLLELMVEQGAQLTLSDDSHGPHQVGLNYHLAKSYLDKCGITSLCMIEKGPDGNGTVVKNVTVDNVWSKFVGTNGITNT
Protein: Carboxy-terminal processing protease (Q72Q11)
Organism: Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Interaction partners:
Sequence:
MKNKERMIWIGIVSFLSFALIFPIETVKGISKTGESYLQIFHEVLSTIHSDYVESVDEEKLYQGAIRGLISSLGDPHSRFMDKDDFSQLQEETRGSFGGLGMEVSFADGAIVVISPIEDTPAMKAGILPQDRIIEIDGKNTHDLSLSDSIKLMRGKVGTSVSIKLERKNQKEPMVLTLVREMIKIRYVRSSFLEKEKLGYIKLNQFMGKENTLSEFKKELNSLKEKGAEGLILDLRMNPGGLLDLAIALSDLFLKPDLDIVSVRGRGGELVRVFRSTAANDKFINLPLVVLINEGSASASEIFAGAMQDHGRGKILGTVSFGKGSVQNIYSLSHNTGIALTIQKYYTPSGKSIHGKGIQPDVIVKPIEPTEDDRFYIRKMAEKKMLETFLLKNPNYSEANFVLLEKYLSEKGIKLSADVARFLYKSKTRQEGQNSILDLELDPQLRKAIEILSPNKDGEKKS
Protein: GH12664p (Protein phosphatase 1c interacting protein 1, isoform A) (Q8MRN4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein
- GH06435p
- GH20441p
- Cytosol aminopeptidase
- Uncharacterized protein
- FI13205p
- Uncharacterized protein, isoform B
- Cytosol aminopeptidase
- GH26058p
- Tubulin beta-2 chain
Sequence:
MEKYECKPEPVEKKEKPVEELMNWDAYYKNRGLVSTRLGSCKADYMHCSTYQEKGNAQEKDKKGKGACCCSSCPVRNREEVYQPRCPAPGQKGKPNRDYMRCFAAKLIVQKLNMPGRDFECQDKLQIKANVCRGCKICLGSSSINVNCLPLNPDKTFQMEAECLQRQLAEGINISVVYLRKEIARGCYFPPAAVVSRMINDFDEIVHDANVELTCKGCTVGIMNIRFAMQMRCQTLKEDAVDGRLAGGQERGCFPNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDSPPRLIDMAGPYPVYSCPNVDDDCVTFEPPAGPATQFSSCQKNVLGEGNANRLCQKHSSPRLRQMHISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFKERPYDEQATAQQILLDHLENPVENLSFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQEGSAQPQDLAKVFTELRDLFNVKAADENQKIQDICAEACALAKSHKKSKNRPASPERTKAGKTDPVEDACETPRKMKKRRPKVKRPYKSRYYSMYRPTERPKANVAIPDADKKVPSHMGWLWTAHPLANKPGWRPGAIRRSIRGLMSYFLKDFPVDNVPVSKYMSYYKHKMSPMSPPGEKAEDLVQVPTLHIEKKNDVYTITLRPLKDAKTLARSANPYVRMKPVQFRIVKNPLLKEIRDLKRCLKGMGFSKCSCHKPLMNCYCRSFVDKKRLLYHVRRECERRKIDSCEDELVLTDTSDSEDEFDFGVTPPAGLMRPERLKSSHVKHTETQYNESDWVNPSLYPHMPDATVQYESCVMGEREKPFNWIYGKGVIQEEPKPPKMRNIPKKPKKKKPVPGRVAGGFSGQDHQDSCVYSRVNNTTIQTKDREIRPICNPPSYSTDSELPLTGDHMRLLDQAAYPPTAPQRQQPWSREMANERKRLRVKRRTKKMVRFDPTLGPHSSDISIN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q7KK41)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQLAR
Protein: Nucleoporin 214 (D4ACK1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear pore complex protein Nup88
- Exportin-1
- Nuclear pore complex protein Nup153
- Nuclear pore complex protein Nup214
- Nuclear pore glycoprotein p62
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup107
- Nucleoporin 205
- Nuclear pore complex protein Nup93
- Nuclear pore complex protein Nup54
Sequence:
MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSVLTVSNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKLSNGASGMVNDMKWNPTVPSMAAVCLADGSISVLQVTDVVKVCATLPPSSGVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYEADHPVRVLDVLWIGTYVFTIVYAGADGALETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQSDQTNWESWVLEDSSRAELPVTDKSDDSLPVGVAIDYTNEVEVAINEEKTLPPAPVLLLLSTDGVLCPFYMINQNPGVRSLIKTLELISAEGERQPKSSGSFPSTPPSPQAPQNLDAPATASSPLPPVSAAPTATFPLPSAGGGPSVFSFGPSPFKSSSIPGEPPPYPTGSDSSRAAPASGTPTFSFAPPSKGTLAPTPAVAPVPTSAAPFTFGSSGFKPPLESTPMSSAPNTGMKPSFPPSTSSVKVNLNEKFTAVASSAPVHSSTSIPSVLPFSSSPKPPASGPLSHPTPLPASPSSMPLKPSVSPSPSVGRSAQTAPSSAPSTGQKSPRVNPPVPKSGSSQARALQPPVTEKQRHQWKESDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTPEEMKMLRTESDDLHTFLFEIREATESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYNQTSPWNRPSTLSTQSDTPSFDSDLEHLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAHPLEGEDARPTPTCREEEAVVPVPRHAPVVRTPSVQPSLLPQAMPFAKPHLIHSSSPAAMSSSISTSATKVIPQGADTTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAVSTLTESTLKNVPQVVNVQELKSNPSPPSAAMGSSGPHSAAKAPHAVLTPVAASQAKQGSLINSFKPSGPTPVSCQLSSGDKAVGPGTAKTESPVTSTPSTGQLNKPFSFASPGTFTFGTITPAPSSSFTATPGAAPPTKESNQLEAFSFGGGGKPFCETIPGNPPATGPPSAPSTSVTTTSLEDSAPTSSKPATPETPVSTASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEESTKPVSKASSTNLAGAQPAKPSGFSFPAASVLGKPVEPSVTSSAPAAPVSALSASTSSSSATVFGSVPLTSAAPSGLMSFSGASLASSKASFSFGNQQTSSAAAAAATPASTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKITEEATPPAVPDKSDHSEVSASTPSLPLQPPSAQLPQASLQTSDPVKKEPVPAQTTDSRPSSSASLVASTESTPVAPGGPDSKTEAVSPASTFAGPGPAVVAAVLLGAGSAASEASGTPSTSSTVSSSTPTPATETAVFGTATSGSSVFTQPPAASSSSAFNQLSSNTATAPSATPVFGQVAASIASTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQSPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPTSTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGGSVFGSTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAASSGGSVFGQQSSTSSGSVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTPTPNTSNLFGNSGAKTFGGFGSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFSGFGSGTGAFTFGSSNSSVQGFGGWRS
Protein: IQ calmodulin-binding protein (Q57ZU4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVDEKLPTLFSPSATVSFAARSTLSRATLFTTLLPSLGTTKVESPRPPPSSRLYAKRHSSVYSRHPLETIVTDQSSSSSAWWAANTENKRYASIATMKVQALEEKFNEQLKSYNAFHPVVVDGGAYSTQAIQRRFNGESVSDSLSKLTDFAATRSVRSTFDDSFVSTMEKISGVQGNFTPRTVERKRAAVITPDGLELSSSSLSLHSDKFTAGIELWLRENKASEEELRQKRLFYDSQRAKSEQRERSQYRQKWQAKLDALHDERLDAFAHSKHSNVLSKRVSIVENLTAATEQRILWSKFLSSEANAESAGSPRTKFTSTWTSNKSASNNELHEWIEGKWHNSTHRHEEAALKIQCAYRCFCAKEEVARRRYARRMVFAGVLSREKEAEAKWENALRMRVSSYDTGGNTMNRLNPSIKLLKEKLLAVVVRRRNAKAQEERYRREIEEYAATSIQRVYRGYLGRFWVKLMRNGDPVEQLRLIRIGRVVVCLQARWRGCLARAAIERQRAAVLVLQRLVRSRAAFLDLCRKRRERRMEVEYGIHKHYIKVIIRFLKRCVNDRKEYMKERWDQLFLIQRIGRGRIGRGIVEKSYKRRCAAQLVVALAIQRRYRGWRGRVKAQYEREQRAEKYLQLCRTDAVQVIERSWRFARGYYIEKSRKARKEAERIARILRRQRREKLNLRRMRIAALKIQYWYFNARYVREVRMKRIEQRRELVRSESAERILRFYREYKFRANRQSPVETAPAAEEEN
Protein: LD47384p (Rab-related GTP-binding protein Chrowded) (RabX1) (Q9V3C2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rabaptin-5-associated exchange factor for Rab5
- Rab GDP dissociation inhibitor
- LD29542p
- Vacuolar protein sorting-associated protein 8 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Receptor-mediated endocytosis protein 6 homolog
- Phosphatidylinositol 3-kinase catalytic subunit type 3
Sequence:
MRGIEGKVLVLGSRGVGKTRLVIRYIKNTLHRKESEVPTIAVSFFTCNIILDEVKIKLQIWDTAGQERYRAVAPMYYRNANAAILVFDLTQYKTFTEIKSWIQELHRNVQDPMILTLVGNKMDMQAQRAVSREEAFVFATSIGATYFETSTETDQGLEQVFISTAQGLVRLADEGKSPSLRSFQSTDSLAYTNTNTAFSHTVAALARSSGNAAFRLPYVDIGLAVEGEDVKTNGVGRLETAPWSIEHIALGEVERPSWCCY
Protein: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV) (Q64690)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q92187}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q92187}. Secreted {ECO:0000250|UniProtKB:Q92187}.
Interaction partners:
Sequence:
MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCLSRSLVNSSDKIIRKAGSTIFQHSVQGWRINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDRAKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCMKQ
Protein: MAS1L (Mas-related G protein-coupled receptor H) (W8W3J1)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MVWGKICWFSQRAGWTVFAESQISLSCSLCLHSGDQEAQNPNLVSQLCGVFLQNETNETIHMQMSMAVGQQALPLNIIAPKAVLVSLCGVLLNGTVFWLLCCGATNPYMVYILHLVAADVIYLCCSAVGFLQVTLLTYHGVVFFIPDFLAILSPFSFEVCLCLLVAISTERCVCVLFPIWYRCHRPKYTSNVVCTLIWGLPFCINIVKSLFLTYWKHVKACVIFLKLSGLFHAILSLVMCVSSLTLLIRFLCCSQQQKATRVYAVVQISAPMFLLWALPLSVAPLITDFKMFVTTSYLISLFLIINSSANPIIYFFVGSLRKKRLKESLRVILQRALADKPEVGRNKKAAGIDPMEQPHSTQHVENLLPREHRVDVET
Protein: Ellipsoid body open, isoform B (X2JDN0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHAASLTTVEGLLQEFYQPSTSNARKREIETNLLAFKSQPEAWQLCLRVATSSDTTENQFLWFFSTSTLEHTITRRWTQLTSTDKTLLRETLWNSYAQLVATPNVAKRHRDTLAQLIALLGKREFPEQDPNYMQHCMELTKTRFQLGINLLKITSEEVVSNRGDLTTEWKQYFYSCISMCVPDVLDLVTKYLLIAVCHINGKDIQTTIPNTLMDFSLTSALPNDNQLSSSILDLLGCVQHLVSWIRTELISEYFLMSILDLSQWRPAHEPISLAALSVLNELLYLQKPLPFPGPLMGGVTSLLEQHNNNRRQSEMYSDKFRELLRLYTTKYAAKLMQEPDLLETFLNLLYSCTTELHGALDFTEKLEIWTPIIKGIAQHPAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNELMEDDTFIQFQTSATEWQQFLDQCFESLALLANTRGAHIVFAQVYNHWSRPQMYLLSLEHALDHGSARSYEAARKLKGANVGEILRDFATVCQAVVRLAPLMDSSTAAPGVADEMECQLQMLSDSLLQTLQLLASNRLYSGGSEMDKATFQTDLDNLYAQVLLAMRSIFPLTKAMSGEELLHRLFAILGSIFACNGSLTAASPIVQQAASELLLFISTVIRPKCLLDIPQIQSLLQAGSRLGAQLPRQVCINVHISLVSYMVLPWKSVPEQQQEYPRRLWMLREYVQGLAQNFLDLDLGQANESKVAATTLSLLGTFTALIEYFKATGGNAKDMLASTFKPILTKALMIFNNFGQSSIAMAITVAEFSLSMLRTLPTHLGAQFIKEMITLFISVSSREQLTLSRLAVMEKILQMFKLIVEQPGSASLGLLPSILDFSTQQILPLLQQQNAATDNSEITSLLYALFDSVLTCKWQFFYKNQLSNGHSGGGSGNFNCSDNLHPAHFMAILNAYGQMLVSGTDPSNVRSVLFSMQNVNERSRLYQRALFKEQLLASFQRALLNLLLSGEGSLHFDMIAQALYAMGQVDRRQLLESFVHASLPVAQTSLEEICQTNDIPTFTQKLTQLMQDAHCVHLNETA
Protein: E3 ubiquitin-protein ligase ariadne-1 (EC 2.3.2.31) (Protein ariadne-1) (RING-type E3 ubiquitin transferase ariadne-1) (Q94981)
Organism: Drosophila melanogaster (Fruit fly)
Function: Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10. Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Appears to function, at least partially redundantly, with the RBR E3 ligase family member park in nuclear localization and morphology. Likely to function in metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and its heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10880484}. Nucleus {ECO:0000269|PubMed:21900267}. Note=Mainly cytoplasmic. {ECO:0000269|PubMed:10880484}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2-18 kDa
- Peroxiredoxin-5
- Ubiquitin-like protein NEDD8
- Ubiquitin-ribosomal protein eS31 fusion protein
- Uncharacterized protein
- Cullin 6
- Cullin 3, isoform F
- Ubiquitin-conjugating enzyme E2-18 kDa
- Ubiquitin-conjugating enzyme E2-18 kDa
- Cullin homolog 1
Sequence:
MDSDNDNDFCDNVDSGNVSSGDDGDDDFGMEVDLPSSADRQMDQDDYQYKVLTTDEIVQHQREIIDEANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKTSRSQCEECEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHCKCGHVFCFACGENWHDPVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVCLGSWEPHGSSWYNCNRYDEDEAKTARDAQEKLRSSLARYLHYYNRYMNHMQSMKFENKLYASVKQKMEEMQQHNMSWIEVQFLKKAVDILCQCRQTLMYTYVFAYYLKKNNQSMIFEDNQKDLESATEMLSEYLERDITSENLADIKQKVQDKYRYCEKRCSVLLKHVHEGYDKEWWEYTE
Protein: Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (P58196)
Organism: Mus musculus (Mouse)
Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9NRQ2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O15162}. Cell membrane {ECO:0000250|UniProtKB:Q9NRQ2}; Lipid-anchor {ECO:0000250|UniProtKB:Q9NRQ2}; Cytoplasmic side {ECO:0000250|UniProtKB:O15162}. Nucleus {ECO:0000250|UniProtKB:Q9NRQ2}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9NRQ2}.
Interaction partners:
Sequence:
MSGLVPTAPEQPTEEMENQIKSPTAVPDAPPDYNSHFAPGPAGPVASPSAGLPMGYYIPQQPGAIPLYHPTGGTHPIQYQPGKYPVTNQPAPIMWMAGPAPVPNCPPGLEYLAQLDNIHVLQHVEPLELMTRFETNNRYDIKNNIDQMVYIVTEDTDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCTCCCFCCPCARQELEVQCPPGVTIGFVAEHWNLCRASYSIQNEKKESMMRVRGPCATYGCGSDSVFEINSLDGVSNIGSIIRKWNGFLSTMVNADHFEIRFPLALDVKMKAMIFGSCFLIDFMYFERPPPRRMSR
Protein: Uncharacterized protein (Q38BJ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDVRDQLMQAAAQTVDALSFTQTHVIDEDFRAHNRATIESVRSLQREQRSRIEQTYGPQSPSADVLALQLLSSYRGEITFLDHSRGRDGRTSPSAAAGVVTSLTHGQCLSFKKEMKQRIHEWERVFCEERGVAVTTRDKAMLRQVYELYKLAKNRLRGEESPTNGGGEDNNNLTNSQSQTQQPQGARSSSERANSAGTVTSGVRVRTPSPSGSQVDNPARRVVGSTTQPSGLQRQVVRSSTSSGLSANEGPGSTQPTIGSGIRVSQMSNEELAAEKRYLKRILHRFESDFEQRNGFAPTRNDRQAHSYEYIRYGELKNEIIRRMPSVAGG
Protein: Protein FAR-RED ELONGATED HYPOCOTYL 1 (Protein PHYTOCHROME A SIGNAL TRANSDUCTION 3) (Q8S4Q6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key regulator of far red / red (FR/R) spectrum-specific responses essential for the adaption to changing light conditions (e.g. de-etiolation), essentially by regulating PHYA shuttling from the cytoplasm to the nucleus and by directly regulating the expression of some target genes, depending on light conditions and phosphorylation status. Binds chromatin at target genes promoters, especially in FR light conditions. Can activate transcription of different genes, some being in a phytochrome A (PHYA)-dependent and other in a PHYA-independent manners. Controls specific aspects of plant development, such as the inhibition of seed germination under FR during salt stress. Essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes involved in photomorphogenesis. Mediates the association of PHYA with HFR1 and LAF1 in the nucleus in response to FR conditions. PHYA-specific signal transducer in response to continuous FR lights. Contributes to inhibition of hypocotyl elongation in continuous blue light (B).
Subcellular location: Nucleus {ECO:0000269|PubMed:11711433, ECO:0000269|PubMed:11726703, ECO:0000269|PubMed:18670649, ECO:0000269|PubMed:18980642, ECO:0000269|PubMed:21884939, ECO:0000269|PubMed:22582101}. Cytoplasm {ECO:0000269|PubMed:11711433, ECO:0000269|PubMed:11726703, ECO:0000269|PubMed:18980642, ECO:0000269|PubMed:21884939, ECO:0000269|PubMed:22582101}. Note=In hypocotyls, mostly present in nucleus of dark (cD) grown plants, but also detected at low levels in cytoplasm of cD and continuous far red (cFR) grown plants. Disappearance of the nuclear pool after exposition of etiolated plants to the light is faster in red (R), blue (B) and white light (WL) than in FR (PubMed:11711433). Shuttles reversibly from cytoplasm to nuclear bodies when dephosphorylated in FR but stay in the cytoplasm when phosphorylated by PHYA in other light conditions (PubMed:18980642, PubMed:21884939, PubMed:22582101). {ECO:0000269|PubMed:11711433, ECO:0000269|PubMed:18980642, ECO:0000269|PubMed:21884939, ECO:0000269|PubMed:22582101}.
Interaction partners:
- Phytochrome A
- ARM repeat superfamily protein
- AP3-complex subunit beta-A
- AP-3 complex subunit delta
- Transcription factor HFR1
- Protein MAEA homolog
- Transcription factor HY5
- Ran-binding protein M homolog
- At4g09200
- SPla/RYanodine receptor
Sequence:
MPEVEVDNNNEKPSEINSFHHMIISSSKNVLKMEEVEVSKKRKFQTDQSDELSLLPLSKHTCFANVACSENTNGNSEIDTEYSMSSYVNSTTSMECNNDIEMKEESSGSCGEDKMISFESHLDYIYGTQNLEDFSEKVIENILYLDEQEEEEEDAKGCSSNAAKFVLSSGRWTVNQDDSTLHETKKPTIDQEFEQYFSTLML
Protein: Large ribosomal subunit protein eL36z (60S ribosomal protein L36-1) (O80929)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL6z/uL6y
- Large ribosomal subunit protein eL27z
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
Sequence:
MTTPAVKTGLFVGLNKGHVVTRRELAPRPNSRKGKTSKRTIFIRKLIREVAGMAPYEKRITELLKVGKDKRALKVAKRKLGTHKRAKRKREEMSSVLRKMRSLGGAAAAEKKM
Protein: Cyclophilin-like protein, putative (EC 5.2.1.8) (Q38D22)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSALVRRVPHIGPVRALHGTTLGRVVVVKLPLQHQRARICGSARWLQGSGCGDRSAGVGPIVIHDDGGNAVTRVKRLPLTLIEEVPLPRRVLTDLELVMMAWCEEHARQYAIIMTVIRLGIFFLLLIIFYVFYRTQLSSERMLRGVDHMPADLRIGSVVYFDITENGMDIGRIVIGLLNENCPHYCEYFHRRCTGSGGNGESFRGMQLSAIVPRHCLIFGDGREMTHDVPGFSPHYLPTEYLGTGSWRGALSSIAYGTNKESPNFAIHVSAGDYAPQIFALVIGGFDVIERINSAGSKHGNSPKKEFIVVECGELCTLAKSHIVPMPWKLYKSISHGYDEEKFGRKISYNFLESSDKGASAEEAREAGSFNSGSNPPTPWWRFL
Protein: Uroporphyrinogen decarboxylase (EC 4.1.1.37) (A0A494BZY8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q38D21)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Casein kinase II subunit beta
- non-specific serine/threonine protein kinase
- Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein
- FACT complex subunit
- Nrap protein domain-containing protein
Sequence:
MSVSSQPNTDGAHRYARANVEKPREYWDYESARIQWSSPERYEIIEKIGRGKYSDVFLGWDTKVRRQVVIKVLKPVKKKKILRELKVLQNLQGGPNIVELYDVVRDPCSKTPSFIFEYVEASDFRTVFPTFSDYDVRYYIFGVLQALEYAHSMGIMHRDVKPNNIAIDHKKRDLILIDWGLAEFFHPLTPYNARVASRYFKGPELLVELPMYDYRLDMWSLGCMLAGMIFMREPFFHGKDNNDQLVRIAKVLGTDELFEYLHKYNLTLPQHLETAVGRHGKKPWTMFVTQENQHLCPKEALDFLDQLLQYDHVKRVQALEAMDHPYFDPVRAECTARIREKKRGNVVTE
Protein: Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) (Q6DKI7)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26755705}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nectin-2
- Poliovirus receptor
- T-cell surface protein tactile
- CD226 antigen
- Nectin-1
- T-cell immunoreceptor with Ig and ITIM domains
Sequence:
MRTEAQVPALQPPEPGLEGAMGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSGVLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERPPHTGPGLTLFPDPRGPRAMEGPLGVR