wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein KIAA2013 (Q8IYS2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MWLQQRLKGLPGLLSSSWARRLLCLLGLLLLLLWFGGSGARRAAGGLHLLPWSRGEPGAAEPSACLEAATRAWRGLRERGEVVPLGPGVPALVANGFLALDVAANRLWVTPGEREPAVAPDFVPFVQLRPLSALAEAGEAVLLLREGLLRRVRCLQLGSPGPGPVAAGPGPASVSGLAAGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPKAFTSTLEKVGDHQFLLYSGRSPPTPTGLVHLVVVAAKKLVNRLQVAPKTQLDETVLWVVHVSGPINPQVLKSKAAKELKALQDLARKEMLELLDMPAAELLQDHQLLWAQLFSPGVEMKKITDTHTPSGLTVNLTLYYMLSCSPAPLLSPSLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLSDLWRLTLQKRGCKGLVKVGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQPVKIYACKAGCLDEPVELTSAPTGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKEDPSV
Protein: ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1 (ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1, isoform CRA_b) (cDNA, FLJ92725, Homo sapiens ATPase, H+ transporting, lysosomal 31kDa, V1 subunit Eisoform 1 (ATP6V1E1), mRNA) (Q53Y06)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD
Protein: Small ribosomal subunit protein uS9x (40S ribosomal protein S16-3) (Q42340)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS7x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS10y
- Small ribosomal subunit protein uS17x
- Small ribosomal subunit protein uS15z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS10x
- Small ribosomal subunit protein eS1z
Sequence:
MATQPATESVQCFGRKKTAVAVTHCKRGSGLIKLNGCPIELFQPEILRFKIFEPVLLLGKHRFAGVNMRIRVNGGGHTSQVYAIRQSIAKALVAYYQKYVDEQSKKEIKDILVRYDRTLLVADPRRCEPKKFGGRGARSRYQKSYR
Protein: VPS39 subunit of HOPS complex (A0A0G2KA50)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 33A
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Syntaxin-17
- CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
- Vacuolar protein sorting-associated protein 33B
- Vesicle-associated membrane protein 8
- Transforming growth factor, beta receptor associated protein 1
Sequence:
MTLLSRCRSWRSFHCRLTAWLPGEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDAKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKQKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSIWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYLEHIIHVWEETGTRFHNCLIQLYCEKVQNLMKDYLLSLPTGKSPVPAGEEAGELGESRQKLLTFLEISSSYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT
Protein: Rho-associated protein kinase let-502 (EC 2.7.11.1) (Lethal protein 502) (Rho-binding kinase let-502) (P92199)
Organism: Caenorhabditis elegans
Function: Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12006612}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12006612}. Cleavage furrow {ECO:0000269|PubMed:12006612}. Note=Colocalizes with nmy-2 myosin thick filaments at the cleavage furrow. {ECO:0000269|PubMed:12006612}.
Interaction partners:
- Ras-like GTP-binding protein rhoA
- cGMP-dependent protein kinase interacting domain-containing protein
- Myosin regulatory light chain
- Myosin-11
- Rho GTPase-activating protein 20
- Myosin-11
- Actin
- Rac-like GTPase
- WAPL domain-containing protein
- Cell death protein 3
Sequence:
MEQDELRDQLVDPKSPINIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFFVNDEWTFATLREASPPVIPSLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTYSNEYSPVKNLLKGHGAGSKQNGIEQHKPQTVVEQPLTNGHASGVPEEKYEAVKMELDSKNREFELLKDSIARNEIRAKMIENEKNSLSTKISDLERELKDNKDKLRHGADSDAKVNELAVELRMSKEYNSEMESELSKFRDKCEQLKEDLRKKSGELAQEKNETQRVFQQKKDADEAFAEIKRDYELLQTRENEKSVQLKKALDERKENGAYQQSVAKATDAEWERKMQFYEKQLEHANDERKREEQKRTAAEFDQSRVARKLAGIEANYELLQNDYKSMKEARKDLERDLQDVITEKRRLEIRVEQLMDSRNTDERVLSLCQDELVESQEEAKYKEDGLRGKIDGFKHELENEKMKTQTLEENLLVADKERGMLKMEVQELMQRHKWEITNKDQTLKHLETQLDEIKQQSKIESSEQESNDKQTIADLRKKLDLEKAHKKAVINKLEEEMAKRQPLKKGEKGVTKSALIKKEREIMALEQERDTMSKRIAALFYENDKQAEHFNIAIQDMQTTQDALRDELKECKEELANRNVNTRYEDKRSLDSREGIPSSLSNQHIQMEGWLSLRDNTKKSRKPKWTNCFVALNEYSFTIYVDEKAVSVILLIEAGAMAHVRHVTAADLRNVDDSQLPKIFHIMYDDASCNSSRHASNSDLSMIESFREESWKRHDFQELSYHIRTFCDVCNKKLSDIIRPTPAFECKNCHFKTHKDHVAQGSLPMCRYNTGLSRELVLMAPQTDNCNKWVSQLRRFIESSRSAAVSVSRVSSRRHAPGSSNSSTIYQ
Protein: Transcription factor IIS family protein (Q3E914)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00649}.
Interaction partners:
- Transcription factor IIS protein
- Transcription elongation factor
- Transcription elongation factor
- BAH and TFIIS domain-containing protein
- DNA-directed RNA polymerase subunit
- Probable mediator of RNA polymerase II transcription subunit 26c
- Probable mediator of RNA polymerase II transcription subunit 26b
- DNA-directed RNA polymerases II, IV and V subunit 11
- RNApolymerase 14 kDa subunit
- DNA-directed RNA polymerase II subunit 4
Sequence:
MIKNDGKMMRVRIAKERSDLCDLTAAAIKATYNTRNPCEVERCIDVLNHLKSLSLSVKDIELSESIVKLETLRSHRNPRIRKEAQALFHSWLKTFYAHGSDNSFKAALTKDRLKMKKHVLTRCSELKKEDEPGTIACQVTAFTLLKNKEDERFQTTVEAVESKTTIKLSELNKKEDQRSLTRETEMIKARNSFLALKQKEDHKSETCDEKYFKKETKTNLKPLNMKTRCVSLEDVTTKKPHEDGSLIKKTKTEKELKNKKVDEMVKLFEAAKKAADVANAKGVLSGKPEASRCINALSLLMKINITPKPKEPRSMMDKLEGLTKHKDRKICHVASALLHLWRQRIREQERKKSVTKASSKNIQRRGNLVM
Protein: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3) (P52287)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Phosducin-like protein
Sequence:
MGEMEQLKQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSLKCERVGVLSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN
Protein: Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) (P13909)
Organism: Bos taurus (Bovine)
Function: Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05121}.
Interaction partners:
- Vitronectin
- Urokinase-type plasminogen activator
- Tissue-type plasminogen activator
- Urokinase plasminogen activator surface receptor
- Plasminogen
- Serpin domain-containing protein
- Type-1 angiotensin II receptor
- Uncharacterized protein
- Vitamin K-dependent protein C
- C-C motif chemokine 2
Sequence:
MRMSPVFACLALGLALIFGEGSASYQPQSAAASLATDFGVKVFQQVVRASKDRNVVFSPYGVASVLAMLQLTTGGETRQQIQEAMQFKIEEKGMAPAFHRLYKELMGPWNKDEISTADAIFVQRDLELVHGFMPNFFRLFRTTVKQVDFSEVERARFIVNDWVKRHTKGMISDLLGEGAVDQLTRLVLVNALYFNGQWKMPFPESNTHHRLFHKSDGSTISVPMMAQTNKFNYTEFTTPDGRYYDILELPYHGNTLSMLIAAPYEKEVPLSALTSILDAELISQWKGNMTRLTRLLVLPKFSLETEIDLRRPLENLGMTDMFRPSQADFSSFSDQEFLYVSQALQKVKIEVNESGTLASSSTALVVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Protein: Chaoptin (Photoreceptor cell-specific membrane protein) (P12024)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion.
Subcellular location: Cell membrane; Peripheral membrane protein; Extracellular side. Note=Extracellular surface of R-cell plasma membrane.
Interaction partners:
- Protein elav
- Opsin Rh6
- Opsin Rh1
- Protein eyes shut
Sequence:
MGLEFFFKFGYAFLTITLMIMIWMSLARASMFDREMEETHYPPCTYNVMCTCSKSSTDLGIVHCKNVPFPALPRMVNQSKVFMLHMENTGLREIEPYFLQSTGMYRLKISGNHLTEIPDDAFTGLERSLWELILPQNDLVEIPSKSLRHLQKLRHLDLGYNHITHIQHDSFRGLEDSLQTLILRENCISQLMSHSFSGLLILETLDLSGNNLFEIDPNVFVDGMPRLTRLLLTDNILSEIPYDALGPLKSLRTLDISHNVIWSLSGNETYEIKASTKLNLDNLHLEYNHIEVLPPNSFKYFDTVNRTFFDGNPIHTLREDAFKPARIREIYMRYCGLTNISPVAFDSLVNSLQILDLSGNNLTKLHHKLFNNFDVLRVISMRDNKIKIQKPTETFNAVHYTLLKLDLSGDRNDPTNLQTLRNMTRMRNMRSLSISRLGSSSVGPEDFKDFGVELEDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYNGGMEKLDVSHNMMLKIPSSSLSSLAALTLCELHLSNNFISTIHSMDLSNKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSHNRDLKVMDKSFMGLENSLIKLGLENISLSTVPEIRLKYLREFRLGYNELPSIPQELAHNMSNLRMLDLSNNDLTNVPLMTQALPHLRRLMLSGNPITSLNNNSFDGVNEDLEMLDISNFRLHYFEYGCLDSLPHLRSLKLTAYSHLEHFNIPHLLRHHYNIRQLWIEAPQPFTRIVKKGSGPTQEMQTLQLGNPTDLQREMEGHLPSKLTNITFSGPQFTNLNERILRGMRSPYLYMQLFNTSLQALPPNFFKYMGRVRNISLDIRYHNRNLKKIPNPNTGAVPYLPNSVFLTDLKMSHTDLNCDCDLGWVEFWQRKRRQYICSSQTWTDTVFRTFMNSPCQVYGRHNCDEHDDDLRETRCENKGGQQLMEALKFDLECGWDNANCREAAFVVVMVCVAMVFWM
Protein: Cyanophycinase (EC 3.4.15.6) (P73832)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
Interaction partners:
- Cyanophycin synthetase
- Isoaspartyl peptidase/L-asparaginase
Sequence:
MPLSSQPAILIIGGAEDKVHGREILQTFWSRSGGNDAIIGIIPSASREPLLIGERYQTIFSDMGVKELKVLDIRDRAQGDDSGYRLFVEQCTGIFMTGGDQLRLCGLLADTPLMDRIRQRVHNGEISLAGTSAGAAVMGHHMIAGGSSGEWPNRALVDMAVGLGIVPEIVVDQHFHNRNRMARLLSAISTHPELLGLGIDEDTCAMFERDGSVKVIGQGTVSFVDARDMSYTNAALVGANAPLSLHNLRLNILVHGEVYHQVKQRAFPRVT
Protein: Fascin-3 (Testis fascin) (Q9NQT6)
Organism: Homo sapiens (Human)
Function: Acts as an actin bundling protein.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
Sequence:
MDETEWIHRHPKAEDLRVGLISWAGTYLTFEACKNTVTATAKSLGRRQTWEILVSNEHETQAVVRLKSVQGLYLLCECDGTVCYGRPRTSHHGCFLLRFHRNSKWTLQCLISGRYLESNGKDVFCTSHVLSAYHMWTPRPALHVHVILYSPIHRCYARADPTMGRIWVDAAVPCLEECGFLLHFRDGCYHLETSTHHFLSHVDRLFSQPSSQTAFHMQVRPGGLVALCDGEGGMLYPQGTHLLLGMGCNPMRGEEWFILQHCPTWVSLRSKTGRFISVIYDGEVRAASERLNRMSLFQFECDSESPTVQLRSANGYYLSQRRHRAVMADGHPLESDTFFRMHWNCGRIILQSCRGRFLGIAPNSLLMANVILPGPNEEFGILFANRSFLVLRGRYGYVGSSSGHDLIQCNQDQPDRIHLLPCRPGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELQGSNLLTVLAPNGFYMRADQSGTLLADSEDITRECIWEF
Protein: Protein SGT1 homolog (OsSGT1) (Suppressor of G2 allele of SKP1 homolog) (Q0JL44)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in basal disease resistance to bacterial blight (X.oryzae). May act as positive regulator of basal defense. Probably required for SCF-mediated ubiquitination, by coupling HSP90 to SCF complex for ubiquitination of HSP90 client proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18257679}. Nucleus {ECO:0000269|PubMed:18257679}.
Interaction partners:
- Cysteine and histidine-rich domain-containing protein RAR1
- Heat shock protein 81-2
- Endoplasmin homolog
- Heat shock protein 81-1
- Os04g0107900 protein
- Hsp90 protein, expressed
- Heat shock protein 81-3
- Os09g0482700 protein
- Os09g0534600 protein
- Os08g0487800 protein
Sequence:
MATAAASDLESKAKAAFVDDDFELAAELYTQAIEASPATAELYADRAQAHIKLGNYTEAVADANKAIELDPSMHKAYLRKGAACIRLEEYQTAKAALELGYSFASGDSRFTRLMKECDERIAEELSEVPVKKAEDGAAAPSVASFVEEKDDAANMDNTPPMVEVKPKYRHDFYNSATEVVLTIFAKGVPAENVVVDFGEQMLSVSIEVPGEEPYHFQPRLFSKIIPEKSRYQVLSTKVEIRLAKAEQITWTSLDYDKKPKAVPQKIIPPAESAQRPSYPSSKSKKDWDKLEAEVKKEEKEEKLEGDAALNKFFRDIYSDADEDMRRAMMKSFVESNGTVLSTNWKDVGSKKVEGSPPDGMELKKWEY
Protein: BHLH transcription factor PTF1 (Q69Y51)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDYSAGSYMWPGNSGSENYNFVDGSSESYAEEGSLPPSGYFMGAGSDRSLKITENERNPTMLANGCLPYNTQAHPLSGQILPKAPTLCSAFQNVSSFMEPVNLDAFGFQGAQNVAMLNKTSLPNGNPSLFDNAAIASLHDSKEFLNGGSIPSFGTVLQALGAGGLKAAQQEQNIRNIPLPTFTSGSHLAVTDAQGPPLPSKIPPLIHDHNSEYPINHSSDVEPQANSAPGNSANAKPRTRARRGQATDPHSIAERLRREKISERMKNLQVLVPNSNKADKASMLDEIIDYVKFLQLQVKVLSMSRLGAPGAVLPLLRESQTECHSNPSLSASTISQGPPDMPDSEDSSAFEQEVVKLMETSIISAMQYLQNKGLCLMPIALASAISNQKGMAAAAAIPPEK
Protein: GATOR complex protein NPRL2 (Nitrogen permease regulator 2-like protein) (Q9VXA0)
Organism: Drosophila melanogaster (Fruit fly)
Function: An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy. In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress. GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development. After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition. At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24786828}. Lysosome {ECO:0000269|PubMed:24786828}. Note=Localizes primarily to the autolysosomes during amino-acid starvation. {ECO:0000269|PubMed:24786828}.
Interaction partners:
- GH04846p
- GATOR2 complex protein Wdr59
- GATOR2 complex protein Mio
- GATOR2 complex protein Wdr24
- GATOR complex protein NPRL3
- Nucleoporin seh1
- GATOR complex protein Iml1
- Protein SEC13 homolog
- GH16429p
- FI04419p
Sequence:
MHSHTNETAATSTTAGAVTNGAGGSGAGAAGAHGSTEGKIRCIFLSEFHATAGCKISCQVPDNYISKDVFDAINVYIIPKQHLQRCILTVNAMDVKIVGYPVGIQDQQKYARNAFLFNLCFVCDSRARSVQYEPVVKKLSEYLIMMEEESCFLSREDDKRRLQNIFETVLRDLNERKVATIVEGDNTIYLKIVMHKPDPPPVKDHMVPLLLANLRDAPLDNWDLTTQQILPYINGINHVARIAAEADVETDLVKSCIQNLVYYGVVQLLPILKYSNVYMTQNLKHLIQSASLSGACRKYVALRPDKTLPSVQRIFQFYASMTHGVTLRAICQRLCPQHHNIDERRMVIFGLQHRFIRCIHKYPVFTGSVPSGRQKMYTGLISFDEICCKTGLSPCTIERDIEKDTNVTVIWK
Protein: GEO02273p1 (MIP03836p) (A1Z933)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD40224p
- Glutaredoxin-related protein 5, mitochondrial
- BolA-like protein DDB_G0274169
- Anamorsin homolog
- DNA-directed RNA polymerase subunit
- Iron-sulfur cluster assembly 2 homolog, mitochondrial
- Iron-sulfur cluster assembly enzyme IscU
- GH14121p
- Adrenodoxin-like protein 1, mitochondrial
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
Sequence:
MSKYDSKYLEEKLKRELQTEYVSVTDESDGCGGKFSAVIVSPAFSGKTLLQKHRLVNSTLAEELKEIHAFSQKSYTPEEWEKVKAQ
Protein: RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (F25B3.3 kinase-like protein) (Q9QUG9)
Organism: Mus musculus (Mouse)
Function: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Enriched at juxtamembrane areas and membrane ruffles. Localizes to the cell bodies and axons of striatal neurons. {ECO:0000250}.
Interaction partners:
- Ras-related protein Rap-1b
- Ras-related protein Rap-1A
- GTPase HRas
- GTPase KRas
- GTPase NRas
- RAS guanyl-releasing protein 1
- Ras-related protein R-Ras
- Ras-related protein M-Ras
- Ras-related protein R-Ras2
- Fermitin family homolog 3
Sequence:
MTSTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQQSRKDNSNSLQMKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHFVHVAERLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKMRQLFCILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKERLSVECRRRAQSVSLEGSAPSPSPTHTHHRAFSFSLPRPGRRSSRPPEIREEEVQSVEDGVFDIHL
Protein: Cadherin-related cell adhesion molecule (Q60833)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
DCQGRLTATGTVVVSVLDINDNPLVFEYREYAPVCLEDIVIGTEVLQVYAASRDIEANAEITYAIISGNEHGKFSIDSKT
Protein: Uncharacterized protein C1322.02 (O94542)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Mating-type switching protein swi10
- DNA repair protein rad16
- Uncharacterized protein C409.16c
- Cell division control protein 24
- Structure-specific endonuclease subunit slx4
- DNA replication ATP-dependent helicase/nuclease dna2
Sequence:
MIESKGETAPSLNLNDVNVEENDAAQSFAEKVQRFRYQMKVHAAPRQKTLHSFLKKDNANIHDFTKVEKPHIRSSKSKVSYNSITSRVTKYFEEKNNSVDQLHSESLTPLSFGHTIPKKKPLLMTASVSEDSRVRVSKRQFKSKVVHPEIAISIAKRHKPKFPLSDELMNVEPGFHHSNIGCQITPYLWISSFRTNVYYLIGNEGDLLSQQVPSISGELNMLRGVCTRIDDDNRYDIEQAGSCFGMSVFPTSDSGEESFTTLESDPIVNCEHDEKKVADNLLVPQVMCSSNISTFFRSPGGKKLYHYLWKNSNALRISSNDLLEILLKHGVYVSLDTLHSWLQERNVNFEK
Protein: Protein phosphatase CheZ (EC 3.1.3.-) (Chemotaxis protein CheZ) (P0A9H9)
Organism: Escherichia coli (strain K12)
Function: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12644507}. Note=Colocalizes with CheA chemoreceptor patches near the cell poles, which requires CheA(short).
Interaction partners:
- Protein-glutamate methylesterase/protein-glutamine glutaminase
- Chemotaxis protein CheW
- Chemotaxis protein methyltransferase
- Chemotaxis protein CheA
- Chemotaxis protein CheY
- Methyl-accepting chemotaxis protein II
- Motility protein B
- Methyl-accepting chemotaxis protein I
- Flagellar motor switch protein FliM
- Methyl-accepting chemotaxis protein IV
Sequence:
MMQPSIKPADEHSAGDIIARIGSLTRMLRDSLRELGLDQAIAEAAEAIPDARDRLYYVVQMTAQAAERALNSVEASQPHQDQMEKSAKALTQRWDDWFADPIDLADARELVTDTRQFLADVPAHTSFTNAQLLEIMMAQDFQDLTGQVIKRMMDVIQEIERQLLMVLLENIPEQESRPKRENQSLLNGPQVDTSKAGVVASQDQVDDLLDSLGF
Protein: Alpha-humulene 10-hydroxylase (EC 1.14.14.113) (E3W9C4)
Organism: Zingiber zerumbet (Shampoo ginger) (Amomum zerumbet)
Function: Catalyzes the conversion of alpha-humulene to 10-hydroxy-alpha-humulene in the second step of zerumbone biosynthesis, a predominating potential multi-anticancer agent.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEAISLFSPFFFITLFLGFFITLLIKRSSRSSVHKQQVLLASLPPSPPRLPLIGNIHQLVGGNPHRILLQLARTHGPLICLRLGQVDQVVASSVEAVEEIIKRHDLKFADRPRDLTFSRIFFYDGNAVVMTPYGGEWKQMRKIYAMELLNSRRVKSFAAIREDVARKLTGEIAHKAFAQTPVINLSEMVMSMINAIVIRVAFGDKCKQQAYFLHLVKEAMSYVSSFSVADMYPSLKFLDTLTGLKSKLEGVHGKLDKVFDEIIAQRQAALAAEQAEEDLIIDVLLKLKDEGNQEFPITYTSVKAIVMEIFLAGTETSSSVIDWVMSELIKNPKAMEKVQKEMREAMQGKTKLEESDIPKFSYLNLVIKETLRLHPPGPLLFPRECRETCEVMGYRVPAGARLLINAFALSRDEKYWGSDAESFKPERFEGISVDFKGSNFEFMPFGAGRRICPGMTFGISSVEVALAHLLFHFDWQLPQGMKIEDLDMMEVSGMSATRRSPLLVLAKLIIPLP