wanglab/gogpt-training-data huggingface dataset:
Protein: Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) (Q61263)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11071899}; Multi-pass membrane protein {ECO:0000269|PubMed:11071899}.
Interaction partners:
- 7-dehydrocholesterol reductase
- Delta
- Sterol O-acyltransferase 2
- Cholesterol 24-hydroxylase
- Cholesterol 25-hydroxylase
- Sterol 26-hydroxylase, mitochondrial
- Cytochrome P450 7A1
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Sulfotransferase 2B1
- Neutral cholesterol ester hydrolase 1
Sequence:
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
Protein: Zeatin O-glucosyltransferase (EC 2.4.1.203) (Trans-zeatin O-beta-D-glucosyltransferase) (Q9ZSK5)
Organism: Phaseolus lunatus (Lima bean) (Phaseolus limensis)
Function: May regulate active versus storage forms of cytokinins, and could have an impact on seed growth. Can also use UDP-xylose to catalyze the formation of O-xylosylzeatin but at much lower affinity.
Interaction partners:
Sequence:
MALNDKSIPHETKVVVLLIPFPAQGHLNQFLHLSRLIVAQNIPVHYVGTVTHIRQATLRYNNPTSNIHFHAFQVPPFVSPPPNPEDDFPSHLIPSFEASAHLREPVGKLLQSLSSQAKRVVVINDSLMASVAQDAANISNVENYTFHSFSAFNTSGDFWEEMGKPPVGDFHFPEFPSLEGCIAAQFKGFRTAQYEFRKFNNGDIYNTSRVIEGPYVELLELFNGGKKVWALGPFNPLAVEKKDSIGFRHPCMEWLDKQEPSSVIYISFGTTTALRDEQIQQIATGLEQSKQKFIWVLREADKGDIFAGSEAKRYELPKGFEERVEGMGLVVRDWAPQLEILSHSSTGGFMSHCGWNSCLESITMGVPIATWPMHSDQPRNAVLVTEVLKVGLVVKDWAQRNSLVSASVVENGVRRLMETKEGDEMRQRAVRLKNAIHRSMDEGGVSHMEMGSFIAHISK
Protein: Protein kinase superfamily protein (F4HWU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g47210/F13I12_260
- Plant intracellular Ras-group-related LRR protein 5
Sequence:
MSCFGWCGSEDFRNATDTGPRPAHNPAGYNGGHYQRADPPMNQPVIPMQPISVPAIPVDELRDITDNYGSKTLIGEGSYGRVFYGVLKSGGAAAIKKLDSSKQPDQEFLSQISMVSRLRHDNVTALMGYCVDGPLRVLAYEFAPKGSLHDTLHGKKGAKGALRGPVMTWQQRVKIAVGAARGLEYLHEKVSPQVIHRDIKSSNVLLFDDDVAKIGDFDLSDQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSSKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSLVTWATPKLSEDKVKQCVDARLLGEYPPKAVGKLAAVAALCVQYEANFRPNMSIVVKALQPLLNPPRSAPQTPHRNPY
Protein: Heat shock cognate 70-kd protein, like (LOC560210 protein) (A8WFS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSPKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPNNTVFDAKRLIGRRFDDPVVQSDMKHWSFKVVSDGGKPKVAVEHKGENKTFNPEEISSMVLVKMKEIAEAYLGQKVTNAVITVPAYFNDSQRRATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGKSSERNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFKRKHKKDISQNKRALRRLRTACERAKRTLSPSSQASIEIDSLYEGIDFYTSITRARFEELCSDLFRGTLDPVEKALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAAVQAAILMGDTSGNVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKQTQTFTTYSDNQPGVLIQVFEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAADKSTGKQNRITITNDKGRLSKEEIERMVQEADKYKAEDDLQREKISAKNSLESYAFNMKNSVEDDNLKGKISEEDKKRVVEKCNEAVSWLENNQLADKEEYEHQLKELEKVCNPVISKLYQGGMPAGGCGAQARAASGASAQGPTIEEVD
Protein: Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4) (Q9NSN8)
Organism: Homo sapiens (Human)
Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.
Subcellular location: Cytoplasm, cytoskeleton. Nucleus. Note=Mainly cytoplasmic and weakly nuclear.
Interaction partners:
- Dystrophin
- Dystrobrevin beta
- Alpha-1-syntrophin
- Dystrobrevin alpha
- Beta-1-syntrophin
- Beta-2-syntrophin
- Dystroglycan 1
- Delta-sarcoglycan
- Epsilon-sarcoglycan
- Utrophin
Sequence:
MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT
Protein: Transaminase A (Q385Q9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- NAD-specific glutamate dehydrogenase
- malate dehydrogenase
- malate dehydrogenase
- Malate dehydrogenase
- Alanine aminotransferase, putative
- Malate dehydrogenase
- Kynurenine aminotransferase, putative
- Adenylosuccinate synthetase
- Multifunctional fusion protein
- Mercaptopyruvate sulfurtransferase, putative
Sequence:
MGKPDPILGLGQDFRMDPAKRKVNLSIGVYRDDADQPFVLECVKQATLGTNMDYAPVTGIASFVEEAQKLCFGPTCAALRDGRIASCQTLGGTGALRIGGDLLNRFVANCNRIYGPDVGYPNHESIFAKAGMELTPYSYYDPATKGFNLAGMLECLDKAPEGSVILVHACAHNPTGVDPTHDDWRQVCDVIKRRNHIPFVDMAYQGFATGQLDYDAFVPRHLVDMVPNLIVAQSFSKNFGLYGHRCGALHISTASAEEAKRLVSQLALLIRPMYSNPPLYGAWVVSSILKDPQLTALWKKELKQMSSRIAEVRKRLVSELKACGSVHDWSHIERQVGMMAYTGLTREQVELLRSEYHIYMTLNGRAAVSGLNSTNVEYVSQAIHNVTK
Protein: NAC domain-containing protein 12 (ANAC012) (Protein NAC SECONDARY WALL THICKENING PROMOTING 3) (Protein SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 1) (Q9LPI7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulate the secondary cell wall lignification of other tissues. Binds to and activates the promoter of MYB46.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:18952777}.
Interaction partners:
- Transcription factor MYB63
- MYB transcription factor
- Transcription factor MYB46
- Transcription factor MYB83
- Transcription factor MYB58
- MYB transcription factor
- Cellulose synthase A catalytic subunit 7
- Homeobox protein knotted-1-like 7
- Transcription factor MYB80
- At5g52380
Sequence:
MADNKVNLSINGQSKVPPGFRFHPTEEELLHYYLRKKVNSQKIDLDVIREVDLNKLEPWDIQEECRIGSTPQNDWYFFSHKDKKYPTGTRTNRATVAGFWKATGRDKIICSCVRRIGLRKTLVFYKGRAPHGQKSDWIMHEYRLDDTPMSNGYADVVTEDPMSYNEEGWVVCRVFRKKNYQKIDDCPKITLSSLPDDTEEEKGPTFHNTQNVTGLDHVLLYMDRTGSNICMPESQTTTQHQDDVLFMQLPSLETPKSESPVDQSFLTPSKLDFSPVQEKITERPVCSNWASLDRLVAWQLNNGHHNPCHRKSFDEEEENGDTMMQRWDLHWNNDDNVDLWSSFTESSSSLDPLLHLSV
Protein: DNA polymerase IV 2 (Pol IV 2) (EC 2.7.7.7) (P9WNT1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Beta sliding clamp
- Possible transcriptional regulatory protein
- Protein RecA
- Putative lipoprotein LppK
- LexA repressor
- DNA ligase C
- DNA polymerase I
- Probable bifunctional transcriptional activator/DNA repair enzyme AlkA
- Probable DNA polymerase III
- DNA ligase B
Sequence:
MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPRKVVTCASYEARAYGVRAGMPLRTAARRCPEATFLPSNPAAYNAASEEVVALLRDLGYPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLLAKGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDRPVRLLGVRLELA
Protein: SIN3 transcription regulator family member A (H3BNA0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYL
Protein: Ciboulot, isoform A (Ciboulot, isoform B) (Ciboulot, isoform D) (Ciboulot, isoform E) (EG:EG0007.11 protein) (GEO07826p1) (RE50273p) (O97428)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Profilin
Sequence:
MAAPAPALKDLPKVAENLKSQLEGFNQDKLKNASTQEKIILPTAEDVAAEKTQQSIFEGITAFNQNNLKHTETNEKNPLPDKEAIEQEKEKNQFIAGIENFDAKKLKHTETNEKNVLPTKEVIEAEKQA
Protein: Regulator of G-protein signaling 2 (RGS2) (O08849)
Organism: Mus musculus (Mouse)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P41220}. Cytoplasm {ECO:0000250|UniProtKB:P41220}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P41220}.
Interaction partners:
- Guanine nucleotide-binding protein G
- cGMP-dependent protein kinase 1
- Adenylate cyclase type 3
- cGMP-dependent protein kinase 2
- Neurabin-2
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSAPGKPKTGKKSKQQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKSLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
Protein: GH12103p (Menage a trois, isoform B) (RH70415p) (Skiff) (Q8T5S9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLEAVMASDINWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKQNDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWVQ
Protein: Alpha/beta-Hydrolases superfamily protein (Q9STM1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAGEEIEREKKSAASARTHTRNNTQQSSSSGYLKTLLLVTFVGVLAWVYQTIQPPPAKIVGSPGGPTVTSPRIKLRDGRHLAYTEFGIPRDEAKFKIINIHGFDSCMRDSHFANFLSPALVEELRIYIVSFDRPGYGESDPNLNGSPRSIALDIEELADGLGLGPQFYLFGYSMGGEITWACLNYIPHRLAGAALVAPAINYWWRNLPGDLTREAFSLMHPADQWSLRVAHYAPWLTYWWNTQKWFPISNVIAGNPIIFSRQDMEILSKLGFVNPNRAYIRQQGEYVSLHRDLNVAFSSWEFDPLDLQDPFPNNNGSVHVWNGDEDKFVPVKLQRYVASKLPWIRYHEISGSGHFVPFVEGMTDKIIKSLLVGEEDVSESREASV
Protein: Integrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (P21815)
Organism: Homo sapiens (Human)
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Subcellular location: Secreted {ECO:0000269|PubMed:11459848}.
Interaction partners:
- Osteopontin
- Integrin alpha-V
- Osteocalcin
- Dentin matrix acidic phosphoprotein 1
- 72 kDa type IV collagenase
- SPARC
- Runt-related transcription factor 2
- Dentin sialophosphoprotein
- Matrix metalloproteinase-9
- Integrin beta-3
Sequence:
MKTALILLSILGMACAFSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRFPVQGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEAENTTLSATTLGYGEDATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTSTNSTEAENGNGSSGGDNGEEGEEESVTGANAEDTTETGRQGKGTSKTTTSPNGGFEPTTPPQVYRTTSPPFGKTTTVEYEGEYEYTGANEYDNGYEIYESENGEPRGDNYRAYEDEYSYFKGQGYDGYDGQNYYHHQ
Protein: Cilia- and flagella-associated protein 43 (E9Q7R9)
Organism: Mus musculus (Mouse)
Function: Flagellar protein involved in sperm flagellum axoneme organization and function. Involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q57WH1}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q57WH1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:31884020}.
Interaction partners:
- Cilia- and flagella-associated protein 251
- Glutamine-rich protein 2
- Cilia- and flagella-associated protein 69
- Coiled-coil domain-containing protein 39
- Tetratricopeptide repeat protein 29
- Sperm flagellar protein 2
- Tetratricopeptide repeat protein 21A
- Cilia- and flagella-associated protein 91
- Cilia- and flagella-associated protein 70
- Dynein axonemal heavy chain 1
Sequence:
MSQDPERDDVTASATASASASAPASASAHYSGSSLSVRWVQGFPSQNVHFVNDQTICYPSGNFVIFINLETKKKTVLQCINGIVGVMATNVPSEVVAFSDRRFKPVIYIYSFPSLTRKNKLKGDILLDYTLLCFSYCGTYLASYSSLPEFELALWNWEASAILCKKSNPGMDVSQMSFNPMNWHQMCLSSSSAMSVWTIERSNQEHHFRIRSVKLPLEDATFLNEPDMLFPTTLPKDLIYGPVLPLSAIAGLVGEEAETFRPKDDIYPLLHPTMHCWTPSSDLYVGCEEGHLLMINTETLKVTVLQKAEEFPLPDGAPLINPLTLVYQKDGILASGIDGVIYSFIIKDSKYQVKTFLEFDGPVTHLVFSPSYKMLLIQTDKGSVYIYTFGAEMPLDKLLDACDGKVQAVSFITPGTKYFLTLTSSGEVSTVSLEDCNCTSRIFLKTQATALACSPSSPTAAVGTVDGYVYFLNILDVESPQMIHQAFLSQSPVKIVTYDQRGIFLLVGTEEGNIFVIDARPSKSFQIFGFTETGKDILQISTVSVMESDVVEVLVLYPLPDMGRSRLEYFTLPVMLPEVVPENFSDERGRLKDDLTHKYLYEVEHTLSSAVLGFTGSKIFGFCSQVPYICSYVMPVKEHTGVLVLKPHQKVQSKQYGSGTIYLSSHGLWLMTIAKCGILCIRDMFSMETFVRCRSHSHQGRGIQNMKMSLDGQHILVNGKDDNTLVCLKWKRLGANIASEIFEHSRPLVLHLSQTVESESVYLALSRESTNEQQEETTESQKHLNSDSSEEEAVIDHKMIPWIQQKMEEAIKKEVRIFSPRRKEIKRGIKELAQVIAMMMEENEKVDIIAKLDEQEFCLDADELERLHDECEEEVAKIRKDVEMHNLAQSYLTELIKEECWNSMAVKGRALKCFHIPYVVDNFPMKERTEEELQELSKVMQQKKTEIECLKLRKEIVEVQATTTIAKKHHEEEEEEEEDEERTIKTTSLPNYLLGSLSTDFGADTSLLTSQLDLHSREEKINQIILLKDIIYNIKRNFNSEFDAAYKQKEIEIARVKEKNVRIAEIISDLELEETVWQPVFEDSEKPERALVVEDDEISFKKYIAPWQRAKIKEVVSTYEMERLQQARISDERQRGLMDMMGGVLEVKKEDILRMVIPQPPFMAKADALWSEDERKQFKEYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQNFDDHLKRLFERRVKAEMVINQEELKINNIIFSLLLDEELSSREQFLNNYLLKKQEEKTKTAEAIQKAREDLDVFKEHHDMLVAEDKILDRSFKKEFSDILGHQVDVLYKLFKRRPRVHKQKTQADVTSLVPYGERPGSAKLNKENLAQLMKSMDELDNINNMPEGLDPSVWEHFCSTRRAKVENEYKVKQKAACLLEMTTFLRKRMEEDDVVHHEIEKVFHELIRLQDEKVRFQVNLTVQILLKQGQVELENFQLMLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKEVHKGIYQIEWEHKKMEMEMEDLNQRAWDIEMLFFSRDRQKYLNEPNYENVIAIQIGIMEQTISVIDKTHKKNVENCKKLLKKLGKYSNQKDVANYTLSCNLREELVAVSERQDICNEIGSKLTCEKIARERYDNQLKQQKLLNISKQQAEQISILQAEVERLRMKTFPALIPM
Protein: Heterogeneous nuclear ribonucleoprotein M isoform a variant (Q59ES8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
NGSHLKTWLKKKGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4I336)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSAAYNLMIKSKSCLFSSSILFVVTLIYLLCTVSASPSLHPDEVEALKDITETLGVKHLNLSEDPCLTKTLVISQGVLKEGQNSTIRCDCHFNNYSTCHIKHFVLQKFNLPGRLPPMLYKFRHLESIDLYNNYLYGSIPMEWASLPYLKSISVCANRLSGDIPKGLGKFINLTLLVLEANQFSGTIPKELGNLVNLQGLGLSSNQLVGGLPKTLAKLTKLTNLHLSDNRLNGSIPEFIGKLPKLQRLELYASGLRGPIPDSIFHLENLIDVRISDTVAGLGHVPQITSTSLKYLVLRNINLSGPIPTSIWDLPSLMTLDLSFNRLTGEIPAYATAPKYTYLAGNMLSGKVETGAFLTASTNIDLSYNNFTWSPMCKERKNINTYESSHSKNRLTRLLPCSAIKQCQNYSRSLHINCGGPDVTIENSRGRFLYEGDNYGLTGSATNYYRKNWGYSNTGDFMDDAITEDTYTVSSESAVSAKYPDLYQNARRSPLSLAYYAFCFENGSYNVKLHFAEIQFSDVEPYTKLAKRVFNIYIQGKLIWEDFSIREEANGTHKEVIREVNTTVTDNTLEIRLYWAGKGTMIIPQRGYYGSLISAVSVCPSSESECGGMKKKISKLKGPDLRTGSFSLRQLKVATNDFDPLNKIGEGGFGSVYKGRLPDGTLIAVKKLSSKSHQGNKEFVNEIGMIACLQHPNLVKLYGCCVEKNQLLLVYEYLENNCLSDALFAGRSCLKLEWGTRHKICLGIARGLAFLHEDSAVKIIHRDIKGTNVLLDKDLNSKISDFGLARLHEDNQSHITTRVAGTIGYMAPEYAMRGHLTEKADVYSFGVVAMEIVSGKSNAKYTPDDECCVGLLDWAFVLQKKGDIAEILDPRLEGMFDVMEAERMIKVSLLCANKSSTLRPNMSQVVKMLEGETEIEQIISDPGVYSDNLHFKPSSLSSDYILSIPSSSESAYDLYPLSPESIVFTIQ
Protein: MEI-217 (Q9U5X8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSRRPEDLLAPIQLRLDFEYRQLLDISPQLLQLIVEEPLQFQEAVRYSVYGLIRSHLKDAGLKPIDINQLHAHWRLVGLPFTPGLQFEPRDQLTRLGLSQVRGILAAFTPQETLVLQSIWYCGQCCMRNAIQTSSTDAPFCSSCSRPMSEYQKLRVTETYRILAVLPISAVQTPRVTNCLHRPKLVRLRAHAHDCELKLGASYLITGYFASSASTYQLEACHLRIN
Protein: Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Q95865)
Organism: Neobatrachus pelobatoides
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000369}.
Interaction partners:
Sequence:
PEVYILILPGFGIISHVVAYYSSKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTTDLNVDTRAYFTSATMIIAIPTGVKVFSWLATMHGGIIKWDAAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFTGYTLHNTWTKAHFGVMFTGVNLTFFPQH
Protein: Large ribosomal subunit protein uL14m (54S ribosomal protein L38, mitochondrial) (O94292)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- mRNA export factor elf1
- Elongation factor 3
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL5m
Sequence:
MYGQVLESLAMIGLKGILKVIDNSGATLAECIRVVRAGKFASLGDEVVVVVKKARSGSSVTAANKVKRGDIHHAIIVRTKSPVRRPDGRYVRFDDNACVLVNKECEPLGTRILSVVANELRTKHHTKIASLAPRTI
Protein: Proliferating cell nuclear antigen (PCNA) (Cyclin) (P04961)
Organism: Rattus norvegicus (Rat)
Function: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P12004}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (By similarity). {ECO:0000250|UniProtKB:P12004}.
Interaction partners:
- Replication factor C subunit 4
- Flap endonuclease 1
- Replication factor C subunit 3
- DNA mismatch repair protein
- Replication factor C subunit 2
- DNA polymerase delta catalytic subunit
- E3 ubiquitin-protein ligase RAD18
- DNA polymerase eta
- DNA polymerase delta subunit 2
- Cyclin-dependent kinase 4
Sequence:
MFEARLIQGSILKKVLEALKDLINEACWDISSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVSIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
Protein: Cyclotide hyen-D (C0HLN8)
Organism: Pigea enneasperma (Spade flower) (Afrohybanthus enneaspermus)
Function: Probably participates in a plant defense mechanism (By similarity). Has strong cytotoxic activity against HUVEC cells (LC(50)= 0.58 uM) and various cancer cells including HeLa (LC(50)= 0.48 uM), MCF-7 and K562. Also displays some hemolytic activity. Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE).
Interaction partners:
Sequence:
GFPCGESCVYIPCFTAAIGCSCKSKVCYKN
Protein: Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form] (Q13421)
Organism: Homo sapiens (Human)
Function: Membrane-anchored forms may play a role in cellular adhesion.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Interaction partners:
- Mucin-16
- Mucin-1
- Cell adhesion molecule CEACAM5
- Glutamate carboxypeptidase 2
- Prostate stem cell antigen
- Epidermal growth factor receptor
- Folate receptor alpha
Sequence:
MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA