wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q38EV3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTSLLPAAESHDVRSVETTDVSSSYTNPAGAPHVSPSSSSTAEKKSVGTMLFSKTLFSLPPVSSVHRCQEDGSNRTLMAFPVDDKHLLVVVGPSSAASDTTTSLYVVRQTVGGSQTCGRVCLPIATVSGCVRDESGHSISQHEKRGSFLMSEQSTDNVDGGRSPDRSSRLISPLDESVDTGSVDNDNSTPQNRVVGGTNASDQEFTNRHNPSHVYLVADAAGHAIWAVEVNTESLGARIVPACCYWGQCMHDGKVDGVKASTRGQHQKGCVASAVPLLGGSKGFADGPFQVARFNSPSSLCWGADMEGGKGRKPRECAVLFVSDEGNHAIRQVDLEKALVRTIAGIGGVSGYRDGGYTASQLQRAAVLLWSSAGLLFVDKPNRAVRLIAQTARAEDGDSGNIMKKPPPLTSVTAPAHPHVETEGDKKERSKQGEEVCEDEVQVSTVAGGISSGVATPFDDDDIRCSSLGTSTAAAVMPDGSGILFADGGSGALQLLSSQGIKMIVSPHGHGNSSGIPPGLVGCTHLVACKLILHSSASPHIAFLASSGSNQTVSMLVLRGGADDGGMTSFNYDGHTNMLLQFAATSELQRGVLRRYKKVENRAGSDYQSTKVSATGTTTASNDCHVKRLFDEALGDLDGNVTPATQTVRTSRTSCAKALPWKTSSGDQQLTDRTGRAAGRVLDIYMRYARRLTRQHMGFVTCSPRCKHYLRNLWGARSLSLIGFWRMVTHAGYFATCSAPTAPLMFPSWDGRSPTRDARRQKGNSVLHLNLCDWRIALELLYEWSIRRHGHHVVSLMEPAYFSRVLVLLYRWRGSMQQQPTTQQGEEGVLLSPEWFADGLFDENDSEVVVAAHEDFLSRIKNAKELLRGAAKARGGDGRQQEGDEVKILGDETLQLLLLNEGPLRQLFNAYGKTTFITTRSTVSHDSTKKPILAMLRLRQSLNIGQEYDKVPLDHVVGMPYKEFRRLFFTMGVFPTLITESLLRRAFVDSLMTPLFRSIQMEIPSETTSNKCKKTKGGSGSNEIKPKGGIHQYVDRSPCNVQRYVSDNVELSFLIFVEAFTRVALTIFSLCPEHDRRAYPTAAAKVEALMRWINRSVELHHTRECDTLFHIGSQKGVAPPVSYTLRQLNRPFPAFILNGITSTTK
Protein: Drebrin-like protein (Actin binding protein 1) (Q9VU84)
Organism: Drosophila melanogaster (Fruit fly)
Function: Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin (By similarity). Does not seem to be involved in actin-based lamella protrusion during cell migration.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Adenylyl cyclase-associated protein
- F-actin-capping protein subunit beta
- FI19014p1
- Glia maturation factor
- Twinfilin
- Actin-related protein 2
- Huntingtin interacting protein 1
- RE12101p
- MYND-type zinc finger-containing chromatin reader Zmynd8
- Amphiphysin
Sequence:
MAVSFEKNRAQIVAAWKDVLDDKSDTNWSLFGYEGQTNELKVVATGDGGVDELNEDLNSGKIMYAFVRIEDPKTGLNKYLLINWQGEGAPVLRKGTCANHIRDVSNLLSGAHLTINARNEDDIDLDRLLKKLSTVSSAYSFKEPRGAMEEQKAPVGTNYTRVIPTKELNASVMQDFWKKEEAEEKLRQEAEKESKRLELQKLEQEQRSREEKEHKEREKLVISTTKLQPAHVPIKTSPQPLSPEKTAPGFANNLTDAERMRQARNQEARELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPPAKPARNSIAQRINVFNQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPAAPVAAEVVSTIAEVEESQPVDDLPLAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRTKVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAADETEITFDPGDVITHIDQIDEGWWQGLGPDGTYGLFPANYVEIIN
Protein: Acyl-CoA desaturase 1 (EC 1.14.19.1) (Delta 9 fatty acid desaturase) (Fatty acid desaturase 1) (Stearoyl-CoA desaturase 1) (P21147)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. Regulates fatty acid desaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, by competing with the acyltransferase STC1 for the common substrate C16:0-CoA. SCT1 sequesters C16:0-CoA into lipids, thereby shielding it from desaturation by OLE1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26928762}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Fatty acid elongase 1
- Protein MGA2
- Fatty acid elongase 2
- Fatty acid elongase 3
- Protein SPT23
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain enoyl-CoA reductase
- Acetyl-CoA carboxylase
- Very-long-chain
- Long-chain-fatty-acid--CoA ligase 4
Sequence:
MPTSGTTIELIDDQFPKDDSASSGIVDEVDLTEANILATGLNKKAPRIVNGFGSLMGSKEMVSVEFDKKGNEKKSNLDRLLEKDNQEKEEAKTKIHISEQPWTLNNWHQHLNWLNMVLVCGMPMIGWYFALSGKVPLHLNVFLFSVFYYAVGGVSITAGYHRLWSHRSYSAHWPLRLFYAIFGCASVEGSAKWWGHSHRIHHRYTDTLRDPYDARRGLWYSHMGWMLLKPNPKYKARADITDMTDDWTIRFQHRHYILLMLLTAFVIPTLICGYFFNDYMGGLIYAGFIRVFVIQQATFCINSLAHYIGTQPFDDRRTPRDNWITAIVTFGEGYHNFHHEFPTDYRNAIKWYQYDPTKVIIYLTSLVGLAYDLKKFSQNAIEEALIQQEQKKINKKKAKINWGPVLTDLPMWDKQTFLAKSKENKGLVIISGIVHDVSGYISEHPGGETLIKTALGKDATKAFSGGVYRHSNAAQNVLADMRVAVIKESKNSAIRMASKRGEIYETGKFF
Protein: Otoconin-90 (Oc90) (Otoconin-95) (Oc95) (Q9Z0L3)
Organism: Mus musculus (Mouse)
Function: Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P81869}.
Interaction partners:
- HERV-H LTR-associating protein 1 homolog
- Otolin-1
- Proton channel OTOP1
Sequence:
MIMLLMVGMLMAPCVGAHALDTPNPQELPPGLSKNINITFFNGVFKNVESVAEIFDCLGSHFTWLQAVFTNFPLLLQFVNSMRCVTGLCPRDFEDYGCACRFEMEGMPVDESDICCFQHRRCYEEAVEMDCLQDPAKLSADVDCTNKQITCESEDPCERLLCTCDKAAVECLAQSGINSSLNFLDASFCLPQTPETTSGKAATLLPRGIPEKPTDTSQIALSGEVAGEVRADTLTTLSRTKSVQDLQDTQASRTTSSPGSAEIIALAKGTTHSAGIKPLRLGVSSVDNGSQEAAGKACDRLAFVHLGDGDSMTAMLQLGEMLFCLTSHCPEEFETYGCYCGREGRGEPRDTLDRCCLSHHCCLEQMRQVGCLHGRRSQSSVVCEDHMAKCVGQSLCEKLLCACDQMAAECMASAFFNQSLKSPDGAECQGEPVSCEDGMLQGTLASSVDSSSEENSEEAPPQMERLRRFLEKPPGPLGARPLGGK
Protein: Fasciclin-like protein FLA9 (Q06I97)
Organism: Triticum aestivum (Wheat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MGFKAAVFTTAVLAVLLCSPASAQKSPPAPAPVSVSIPPSLAPAPAPAPRYVDLAALLDVAGPFHTFLTYLQKTNVIQTFQAQANKTDEGITIFVPKDSAFAALKKSTFSNLTGDQLKTLLLYHAFPKYYPLAQFRNLSSLNPVNTFAGSPYTLNLTDDMGSISVESMWSKPKISSSVYATKPIAVYSINKVLLPMQLFSKDPPLAPAPAPAPESGASDIAPSPDGGKAGARNGKADSTSAGHVGAANCFGLLAAAAGGLMLLW
Protein: Uncharacterized protein (F4IUI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLNVHSHNNNLSNGDKTPLVLSPMSSLHATVSLPLFSNSNHKKLTCAATLSPPPWKQSRRVISVSFFLSRLLLLPNDAMAGGLMDKLDKYVKRKKLDPLEAYVPPVILAQLQIQDLEGFLNVEKPEFEACRRQLRSGPASSLRVNIRAYASDDGFSKTATDDVDRCLRALEELDSLFLRASRKDSNATVVLMKSQLGTALTALDSLLQTVPSQVLDKGKAMVEVYRSASEEDAGSDDLESSEIKQLQSILCRSFDQLTDASRCR
Protein: B9 domain-containing protein 1 (Endothelial precursor cells protein B9) (Q9R1S0)
Organism: Mus musculus (Mouse)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21725307, ECO:0000269|PubMed:22179047}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Interaction partners:
- B9 domain-containing protein 2
- Transmembrane protein 231
- Tectonic-1
- Tectonic-2
- Meckelin
- Coiled-coil and C2 domain-containing protein 2A
- Transmembrane protein 216
- Centrosomal protein of 290 kDa
- Tectonic-3
- Jouberin
Sequence:
MAAASPSVFLLMITGQVESAQFPEYDDLYCKYCFVYGQDWAPTAGLEEGISQIASKSQDVRQALVWNFPIDVTFKSTNPYGWPQIVLSVYGPDVFGNDVVRGYGAVHVPLSPGRHKRTIPMFVPESTSTLQKFTSWFMGRRPEYTDPKVVAQGEGREVTRVRSQGFVTLLFNVVTKDMKKLGYDTGPVDTQGVLGPSLPQGNPQ
Protein: Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3) (Q9Y4A8)
Organism: Homo sapiens (Human)
Function: Activates erythroid-specific, globin gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Transcription factor MafK
- Transcription factor MafG
- Transcription factor Maf
- Transcription factor MafF
- Protein c-Fos
- Transcription factor JunD
- Transcription factor Jun
Sequence:
MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQDELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQLLREVRALGVPFVPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEEKAPAEPTAQVPDAGGCASEENGVLREKHEAVDHSSQHEENEERVSAQKENSLQQNDDDENKIAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLSSQPENSLEGISLGDIPLPGSISDGMNSSAHYHVNFSQAISQDVNLHEAILLCPNNTFRRDPTARTSQSQEPFLQLNSHTTNPEQTLPGTNLTGFLSPVDNHMRNLTSQDLLYDLDINIFDEINLMSLATEDNFDPIDVSQLFDEPDSDSGLSLDSSHNNTSVIKSNSSHSVCDEGAIGYCTDHESSSHHDLEGAVGGYYPEPSKLCHLDQSDSDFHGDLTFQHVFHNHTYHLQPTAPESTSEPFPWPGKSQKIRSRYLEDTDRNLSRDEQRAKALHIPFSVDEIVGMPVDSFNSMLSRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDVCNLQAKKETLKREQAQCNKAINIMKQKLHDLYHDIFSRLRDDQGRPVNPNHYALQCTHDGSILIVPKELVASGHKKETQKGKRK
Protein: Cilia- and flagella-associated protein 276 (E1B9I5)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}. Cytoplasm {ECO:0000250|UniProtKB:Q5T5A4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5T5A4}.
Interaction partners:
- Protein Flattop
- Tektin-1
- Tektin-4
- Outer dynein arm-docking complex subunit 2
- Cilia- and flagella- associated protein 210
- Cilia- and flagella-associated protein 52
- Cilia and flagella associated protein 45.
- Piercer of microtubule wall 1 protein
- Tektin-3
- Cilia- and flagella-associated protein 107
Sequence:
MPLTRDPFQNPALDKDDSYLGKSRASKKLPYKNPTHLAQQQEPWCRLSSTPTITSMKRDGFFFYSEIPKDDLDFRLAALYNHHTGTFKNKSEILTHQETIQDTRRIKTQFPGEFLPAPQPPLITSRANIRHWINPKKESIHSIQGSIVSPHTAATNGGYSRKNDGGFFST
Protein: Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9) (Spermatid perinuclear ring manchette protein K9) (Q8CIS9)
Organism: Rattus norvegicus (Rat)
Function: May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). May be involved in spermatid nuclear shaping and sperm development.
Interaction partners:
Sequence:
MSFRQISSSFRSSSGSSCGGGGGRGASRGSMRSSFGRSSRAGGESRFGSSSGFGGGGFSACGTGGGGSFGSSYGGGYGRGFSAGSSSGMFGGSSRGCFGGGSGGGFGGGSGGGFGGGFGGGFGGGSGGGEGSILNTNEKVVMQNLNSRLASYMDKVQELEEDNANLEKQIQEWYSRKGNRVFQKDYSHYYNTIEDLKDRIVDLTARNNKALIDMDNTRMTLGDFRVKLEMEQSLPQGVDADINGLQKVLDDINMEKSDLEIQFDSLDDELKALKKSHKEEMNQLTGLNDGDVNVEINVAPSTDLTQVLNDMREEYEHLISKNRQDIEQHYESQMTQIEHQLTNSGPEMETNMKQVSQLQHSVQELNIELQTQLTTKSALEKALEDTKNRYCGQLQQIREQISEMEAQLAQVRAETECQNQEYGLLLSIKTRLEKEIETYRKLLEGGQQDFESSGAGQIGFGSGKGGQRGSGGSYGGGSGDSYEGESGGSYGGGSGGSHGGKSGGSYGGGSSSGGGSGGSYGGGSGGSHGGKSGGSHGGGSGGSYGGGSGSGGESGGSYGGGSGGSHGGQKGGSGGSYEGGSGGSYGGGSGSGGGSGGSYGGGNTRPSQSQSSQIPRLR
Protein: Probable indole-3-pyruvate monooxygenase YUCCA9 (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA9) (O64489)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin biosynthesis. Belongs to the set of redundant YUCCA genes probably responsible for auxin biosynthesis in roots.
Interaction partners:
- L-tryptophan--pyruvate aminotransferase 1
- Aromatic aminotransferase ISS1
- Tryptophan aminotransferase-related protein 1
- Tryptophan aminotransferase-related protein 2
- Transcription factor PIF7
- Amidase 1
- Auxin-responsive protein IAA29
- Transcription factor PIF4
- Auxin transporter protein 1
- Anthranilate synthase beta subunit 1, chloroplastic
Sequence:
MENMFRLMASEEYFSERRCVWVNGPVIVGAGPSGLATAACLHDQGVPFVVVERSDCIASLWQKRTYDRLKLHLPKKFCQLPKMPFPDHYPEYPTKRQFIDYLESYANRFDIKPEFNKSVESARFDETSGLWRVRTTSDGEEMEYICRWLVVATGENAERVVPEINGLMTEFDGEVIHACEYKSGEKFRGKRVLVVGCGNSGMEVSLDLANHNAITSMVVRSSVHVLPREIMGKSTFGISVMMMKWLPLWLVDKLLLILSWLVLGSLSNYGLKRPDIGPMELKSMTGKTPVLDIGALEKIKSGDVEIVPAIKQFSRHHVELVDGQKLDIDAVVLATGYRSNVPSWLQESEFFSKNGFPKSPFPNAWKGKSGLYAAGFTRKGLAGASVDAVNIAQDIGNVWREETKRQKMRRNVGHRRCISVA
Protein: Integrin alpha-9 (Integrin alpha-RLC) (Q13797)
Organism: Homo sapiens (Human)
Function: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Integrin beta-1
- Vascular cell adhesion protein 1
- Osteopontin
- Tenascin
- Fibronectin
- Tenascin-X
- Tenascin-N
- Tenascin-R
- Integrin beta-7
- Integrin beta-3
Sequence:
MGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGAPQDKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGETMGQVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEERELPPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPTSFVYGESVDAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEMFHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ
Protein: Protein flightless-1 (Flightless-I) (Q24020)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development.
Interaction partners:
- LD20892p
- LD07988p
- FI03527p
- Anoctamin
- Phospholipid-transporting ATPase
- Brahma associated protein 55kD
Sequence:
MSVLPFVRGVDFTKNDFSATFPSSMRQMSRVQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEKIFGELTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLSNNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSLEVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELTAGVELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLEMVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYNIDFSLQTQLRLAGAAVPPSMPSSATPKDSTARKIRLRRGPRSEGDQDAAKVLKGMKDVAKDKDNEAGAVPEDGKPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYDTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGWSAFKVYL
Protein: Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) (O09159)
Organism: Mus musculus (Mouse)
Function: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
Subcellular location: Lysosome.
Interaction partners:
- Alpha-mannosidase 2C1
- Epididymis-specific alpha-mannosidase
- Beta-mannosidase
- Beta-glucuronidase
Sequence:
MGTGPLTSGVRAGGGNTGWLWMSSCNLGSPVLPISFLFWLLLAAPGARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGILSDVQHASVQYILDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARLSHYKQNFSFCRELNISICPVSQTSERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYYSETYQWELLFPASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLLMKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLETDTGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTGPTSYPEPSKLDPTSVTLKPMEIRTFLASVQWQEHRPA
Protein: Peptidase S1 domain-containing protein (A1ZA42)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSNFIIGIAVICCLWRRVQGFQMLLEEDCGIPHNISERSVNAKLAQNPWMAYLETPKGFHCSGTLINHLFVLTAAHCVPDDLLITVRLGEYNTKTKVDCDNHLCQEPFQEYNVDMGFRHRYYNANDQTNDIGMLRLGRRVEYLNHIRPICIFASNRFQEPIDQLTWFTTTVWRETAANATSKVLRTMNIDRQPKETCSEIYGWNMTFEQICAGNTLSQLCSTDSGAPQIRKMWHNGSDRYVQLGIASRVKGQCQNSGILMDLLSYADWIKRVVRQYGPSTDMNRSLKKWVDKIPVFYYPK
Protein: GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (K7EMD7)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367138}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367138}.
Interaction partners:
Sequence:
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFNCAGS
Protein: RNA-binding protein Hfq (P0A1R0)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells.
Interaction partners:
- Ribonuclease E
- Polyribonucleotide nucleotidyltransferase
- tRNA dimethylallyltransferase
- Translational regulator CsrA
- Poly
- RNA polymerase-binding transcription factor DksA
- Transcription termination factor Rho
- RNA polymerase sigma factor RpoS
- Ribonuclease 3
- DNA-binding protein HU-alpha
Sequence:
MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGASNNYHHGSNAQGSTAQQDSEETE
Protein: FPL domain-containing protein (Q38DZ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQKAKNQSYEKFSQENVSRLCMALKTTDESQAFTTNNISEILRELAQAIIWGDKKNNASFDVFLELDMITTLESIVTNVESPSNVKAEVLRFVTLMLHNLTMKENVYYICSKNHLNKMISIDLNENDDELLSVYVSFLKSLALRCDETTVQFFFIRQLGVFPLFDYAAKLINTSDRMARGAARQVVISVARLQSTFLTSFMEKALPDILRIISKHVWLEIGILSEAVNRYHDAVGDADDATPLPTVDAIRSLTEDVLDDLLYVNDLFAVSSTVVERELRPALVTGIIDPLLALIEAPMKSSTVTRSAFAPVMQPALALCVITRWLLLGKENRIHQVLFDGLLGPKGSDPAECLLGRILSKGCMHCLSAGVVLLGAIVNVGAFNERGNMSDERLCNEIGTADRISNRDDNEVEVSPSKKQLDGDKDPAECCMGTAVDALPSYETFLRDVKSSMGSTAHREPWCICLVGALYRFITCSLLTRLSAFELSLNLLKTFVPESRERRTVSVALASLCEGVLRRRLLAYYDTLIRRKDCRSDENSGNRGLLMANKDCFRSACETLFLEMERVCNGAEPRVEYSFDKLGREVALLLPLLPYGGYSSTERLCCQRQLTSHPQRLADVQGVIGDLVSYHHRAAHSPTEQKDREFMMWASVRRMLYDTMQQEDSFILRLRKYGVQHRVGASVGRLSSTTTRFRCELVKVAVPPGKASKVVPIGKPMNMLLLETEIIFVEPRDMESTSAADIVNEPVLFPMPTVYVQAALSRTPFSVVFTYFHPDNPMRLHVAFRHSKVAQSVINTTNERSAYCRCHGAALVCGALNAEPPH
Protein: Plectin/eS10 N-terminal domain-containing protein (O01869)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS13
- 60S ribosomal protein L32
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL28
Sequence:
MFIPKSHTKLIYEYLFNEGVTVAKKDFNAKTHPNIEGVSNLEVIKTLKSLASRELVKEQFAWRHYYWYLTDAGILYLREYLALPAEIVPATIKTKPREIRVPHEDRAPRAAQGEKGDREAYRTEKVTEAGPGGAPVYRAGFGRGAPPPQ
Protein: Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase) (P32875)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03123, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
Interaction partners:
- Putative lipoate-protein ligase A
- Octanoyltransferase, mitochondrial
- Glycine cleavage system H protein, mitochondrial
- NifU-like protein
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
- Biotin synthase, mitochondrial
- Cysteine desulfurase, mitochondrial
- BolA-like protein 1
- BolA-like protein 3
- Iron-sulfur assembly protein 2
Sequence:
MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK
Protein: Histone H3-like centromeric protein cnp1 (Centromere protein 1) (CENP-A homolog) (CENPA homolog) (Silencing in the middle of the centromere protein 2) (Q9Y812)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
Subcellular location: Nucleus {ECO:0000269|PubMed:10864871}. Chromosome, centromere {ECO:0000269|PubMed:10864871}. Note=Localizes to the nonrepetitive inner centromere. {ECO:0000269|PubMed:10864871}.
Interaction partners:
- Inner kinetochore subunit cnp20
- Histone H4
- CENP-A histone chaperone scm3
- Histone H2B-alpha
- Histone acetyltransferase type B subunit 2
- Inner kinetochore subunit mhf2
- Inner kinetochore subunit mis6
- Inner kinetochore subunit mhf1
- NASP-related protein sim3
- Inner kinetochore subunit wip1
Sequence:
MAKKSLMAEPGDPIPRPRKKRYRPGTTALREIRKYQRSTDLLIQRLPFSRIVREISSEFVANFSTDVGLRWQSTALQCLQEAAEAFLVHLFEDTNLCAIHAKRVTIMQRDMQLARRIRGA