wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclic nucleotide-gated channel (P90975)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYQVPKRAKTNLAREIRKREFSYVDRQKASKPTQLSEKGWKSPRSEDSFDLLDPANASKEPSASTRPLPYPPTRPPEVVIQIDEVESPILGLIDETDDHELDGRLDPASSFDANSLSATRASSIIEDDVRSQISFIMRERLHSIAKEVHRRTSAVREDLIRETPEDTVSMASNVPKQNEHRPSLMSLIGLQNRSESPTVDTVKNCFGFSLKGTFHPYGRFYMTWLSLVTLCFLFNAFCIPLRSSYPYQTADNWMYWFIVDYSCDLVYVIDMLLIKPRLRFTRGGIQVKIYKDTQRHYLMTRTFKLDILSILPTDLMYFFFGKMPIWRINRVLKINSFWLLFDMLDNSFANPYAIRIARTLSYMIYIIHCNSCVYYKLSALQAFGQIAYLENGKWYLNKWVYNNQGNAYIRCFYFTAAVATSTGNNPAPTNVIEYIYMTCSWMMGVFVFALLLGQIRDIVSNANRNREEFQRKMDLALGECKKLGLKMETTNRVRDWFIYTWQQQKTLDEKKLIEKLPLKLQTDLALSVHYTTLSKVQLFQDCDRALLRDLVLKLRPVIFLPGDMICLKGDVGKEMYIINQGILQVVGGDHNEKIFAELAQGAVFGEISLLAIGGNNRRTASIRAKGYCTLFVLAKEDLNDVIRYYPQAQTILRRKAAAMLKNDKKSDEKTEKIKAQAELEDRCKINPRQVPKLITLIANMTEMNENKGVQELKKVIEEETEKSRRQSIYYPWSTLQRDDDDEEEWNDEEDLSDVGEDFDLDPTNHSDDEDPMEDVDLAPEVHDDDWDQPGTSGTQKLHAD
Protein: Receptor-like protein kinase ANXUR1 (EC 2.7.11.1) (Q9SR05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor-like protein kinase that controls pollen tube behavior by directing rupture at proper timing to release the sperm cell.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- GPI-anchored protein LORELEI
- GPI-anchored protein LLG2
- Rapid alkalinization factor 23
- Protein RALF-like 1
- GPI-anchored protein LLG1
- GPI-anchored protein LLG3
- Putative respiratory burst oxidase homolog protein H
- Cyclase-associated protein 1
- Putative respiratory burst oxidase homolog protein J
- Dolichol kinase EVAN
Sequence:
MSGKTRILFFLTCLSFLLVFPTRSNGQDLALSCGTSEASADQDKKKWEPDTKFLKTGNSIHATATYQDPSLLSTVPYMTARIFTAPATYEIPIKGDKRHLLRLYFYPSTYTGLNISNSYFTVEANDVTLLSNFSAAITCQALTQAYLVKEYSLAPTDKDVLSIKFTPSDKYRDAFAFINGIEVIQMPELFDTAALVGFTDQTMDAKTANLQSMFRLNVGGQDIPGSQDSGGLTRTWYNDAPYIFSAGLGVTLQASNNFRINYQNMPVSIAPADIYKTARSQGPNGDINLKSNLTWMFQIDKNFTYILRLHFCEFQLSKINQKVFNIYINNRTAQADTTPADIIGWTGEKGIPMYKDYAIYVDANNGGEEITLQMTPSTFGQPEYYDSSLNGLEIFKMDTMKNLAGPNPEPSPMQAEEEVKKEFKNEKRHAFIIGSAGGVLAVLIGALCFTAYKKKQGYQGGDSHTSSWLPIYGNSTTSGTKSTISGKSNNGSHLSNLAAGLCRRFSLPEIKHGTQNFDDSNVIGVGGFGKVYKGVIDGTTKVAVKKSNPNSEQGLNEFETEIELLSRLRHKHLVSLIGYCDEGGEMCLVYDYMAFGTLREHLYNTKKPQLTWKRRLEIAIGAARGLHYLHTGAKYTIIHRDVKTTNILVDENWVAKVSDFGLSKTGPNMNGGHVTTVVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEILCARPALNPSLPKEQVSLGDWAMNCKRKGNLEDIIDPNLKGKINAECLKKFADTAEKCLNDSGLERPTMGDVLWNLEFALQLQETADGTRHRTPNNGGSSEDLGRGGMAVNVAGRDDVSDLSSEDNTEIFSQIVNPKGR
Protein: NAD-dependent protein deacetylase (EC 2.3.1.286) (A0A8I6A7C4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
GCGHGGGWHQHTQWYPRLQVCCSSLGCHFLTVFCRAAQPFPSLYRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQDLIQRENGKLDGQDG
Protein: Intermembrane phospholipid transport system binding protein MlaC (P0ADV7)
Organism: Escherichia coli (strain K12)
Function: Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.
Subcellular location: Periplasm {ECO:0000305|PubMed:19383799}.
Interaction partners:
- Intermembrane phospholipid transport system binding protein MlaB
- Intermembrane phospholipid transport system permease protein MlaE
- Intermembrane phospholipid transport system binding protein MlaD
- Intermembrane phospholipid transport system ATP-binding protein MlaF
- Intermembrane phospholipid transport system lipoprotein MlaA
- Acid stress protein IbaG
- Lipopolysaccharide export system protein LptC
- Outer membrane porin F
- LPS-assembly protein LptD
- Lipopolysaccharide export system protein LptA
Sequence:
MFKRLMMVALLVIAPLSAATAADQTNPYKLMDEAAQKTFDRLKNEQPQIRANPDYLRTIVDQELLPYVQVKYAGALVLGQYYKSATPAQREAYFAAFREYLKQAYGQALAMYHGQTYQIAPEQPLGDKTIVPIRVTIIDPNGRPPVRLDFQWRKNSQTGNWQAYDMIAEGVSMITTKQNEWGTLLRTKGIDGLTAQLKSISQQKITLEEKK
Protein: Exocyst complex component 7 (Exocyst complex component Exo70) (Q9VSJ8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation.
Interaction partners:
- Exocyst complex component 4
- Exocyst complex component 1
- Exocyst complex component 8
- Exocyst complex component 5
- Exocyst complex component 3
- Exocyst complex component 2
- Exocyst complex component 6
- Rab11
- Cdc42 homolog
- Ras-related protein Ral-a
Sequence:
MNNLDSSLQAHNKLEKEATNLALLKDRVDKYHDLSTQMSSILTIFEKRLGNLEQTILPVYQETEQLQKRQQNLEATLNCLESVLSHYDVSQEVCQLIHQGPVEGNISVFLDALAKLRDANDYFRHNNSQSVELENVTSLFNTGCEGLSQHYSMLLKKHSAPLKPVELLDLIYIEDDSSDEYTSFRQLSQTTREELYTISHWLEQNLREYTNIYATERGEVVLRSLQLLKDHQKSNSWGHEALRPRHSGRQTEPKKTTSARLQQIFEKKANKLYLRATQTIEQSTGFSIKKASSHSDHLTSEDLMDGDQELDKYLVMLLGLQRLLNWERAIMIDIIPQSKHNEVFATLAYNAIDLVVKDAEAITQRILRCISRKEWTSALGIFSALKRVILLQPDIDRTYDPAQREQLKKVLKKLQHTGAKALEHFLDVVKGESSTNIVGQSNVPKDATVHELTSNTIWFIEHLYDHFDVIGSILAQDVLYSTQLDTILMKKALPVEERNKALLAIYIKKALAELNLSIMNKCEQYNDQATKHLFRLNNIHYILKSLQRSNLIDLVTLAEPECEHSYMEMIRELKASYQKTWSKMLVGIYSLDELPKPVAGKVKDKDRSVLKERFSNFNKDFEEACKIQRGISIPDVILREGIKRDNVEHILPIYNRFYEIYSGVHFSKNPDKYVKYRQHEINAMLSKLFDDSA
Protein: WASP actin nucleation promoting factor (C9J3B7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLP
Protein: Probable prefoldin subunit 3 (O18054)
Organism: Caenorhabditis elegans
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Interaction partners:
- Probable prefoldin subunit 5
- Probable prefoldin subunit 6
- Probable prefoldin subunit 4
- Prefoldin subunit 2
- Probable prefoldin subunit 1
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit eta
- EGF-like domain-containing protein
- EGF-like domain-containing protein
Sequence:
MSDTADSLSARGIPKSELIEDVESWLTKEKLSIEEAEVVLREKYGKYKYVESSMLAQKVRMSEKIPEFENSLSIIDTLIAKRAADESFETTFLLSDDVYTKATVQKPEKVSIWLGANVMVEYDLENARKLLDKNRGSVQKVVDELTNELSYIKDQITTTEVNMSHIVNFGVNKRRAALAVNNGAK
Protein: Vicilin Cor a 11.0101 (7S globulin) (7S seed storage protein) (7S vicilin-like protein Cor a 11) (Allergen Cor a 11) (Vicilin Cor a 11) (Vicilin HZ.1) (allergen Cor a 11.0101) (Q8S4P9)
Organism: Corylus avellana (European hazel) (Corylus maxima)
Function: Seed storage protein. Does not have superoxide dismutase (SOD) activity.
Interaction partners:
Sequence:
MLPKEDPELKKCKHKCRDERQFDEQQRRDGKQICEEKARERQQEEGNSSEESYGKEQEENPYVFQDEHFESRVKTEEGRVQVLENFTKRSRLLSGIENFRLAILEANPHTFISPAHFDAELVLFVAKGRATITMVREEKRESFNVEHGDIIRIPAGTPVYMINRDENEKLFIVKILQPVSAPGHFEAFYGAGGEDPESFYRAFSWEVLEAALKVRREQLEKVFGEQSKGSIVKASREKIRALSQHEEGPPRIWPFGGESSGPINLLHKHPSQSNQFGRLYEAHPDDHKQLQDLDLMVSFANITKGSMAGPYYNSRATKISVVVEGEGFFEMACPHLSSSSGSYQKISARLRRGVVFVAPAGHPVAVIASQNNNLQVLCFEVNAHGNSRFPLAGKGNIVNEFERDAKELAFNLPSREVERIFKNQDQAFFFPGPNKQQEEGGRGGRAFE
Protein: Probable diguanylate cyclase DgcQ (DGC) (EC 2.7.7.65) (Cellulose synthesis regulatory protein) (P76330)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Flagellar brake protein YcgR
- Cyclic di-GMP phosphodiesterase PdeH
- Cyclic di-GMP phosphodiesterase PdeR
- Probable diguanylate cyclase DgcE
- Cyclic di-GMP phosphodiesterase PdeL
- Probable cyclic di-GMP phosphodiesterase PdeK
- Oxygen sensor protein DosP
- Probable cyclic di-GMP phosphodiesterase PdeD
- Probable cyclic di-GMP phosphodiesterase PdeI
- Probable cyclic di-GMP phosphodiesterase PdeC
Sequence:
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGRNRVFASDNA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (C8V7X8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Low-temperature viability protein ltv1
- rRNA processing protein Bystin, putative
- Serine/threonine-protein kinase RIO2
- Pre-rRNA processing protein Tsr1, putative
- 20S-pre-rRNA D-site endonuclease NOB1
- 40S ribosomal protein S3
- 40S ribosomal protein S10a
- Serine/threonine-protein kinase RIO1
- Small ribosomal subunit protein uS5
- Uncharacterized protein
Sequence:
MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVIDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGTLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFSIYLNYTRSLRFDDKPDYSYLRKIFRDLFVRESFQYDYVFDWTVYKYQKNAAMMSDAKKDKEAEEQARRQGATMPLTTSGAAKPGAISSQRRKIMERGALDNTPDTNRAVGGSDRILRR
Protein: Necessary for collagen adhesion A1 (Necessary for collagen adhesion A2) (Q58ZK4)
Organism: Haemophilus ducreyi
Interaction partners:
Sequence:
MKKIITILCLACGFSNFGHAIVTPGGIPPKCYEFLYPKGTNVLSKLQTTPNDNQLEQINLSDCKLDFPWSPLNTFADYPENRRIETLLDLWRVVRWNRGYLQEHNANLYDLYQRMNALESLSGLGNSESIAEFTKTIYPLIGGEILKQVNQKVHELRKETYMNTANTAAMSSLNFGNSQGISFGAAIGGHKGQHSLALGTAYTDYQTQVNVKIALPVRQPKPSNITYGIGFVYNFQ
Protein: Cytochrome P450 734A4 (EC 1.14.-.-) (Q69XM6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis. Is a multifunctional and multisubstrate enzyme that controls the endogenous bioactive BR content both by direct inactivation of castasterone (CS) and by decreasing the levels of BR precursors. Catalyzes the oxidation of carbon 22 hydroxylated BR intermediates to produce C26 oxidized metabolites.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 85A1
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- 4-coumarate--CoA ligase
Sequence:
MMEAVAVAAAVLLLLHVAARVADAVWWRPRRLEAHFAGQGVRGPPYRFLVGCVREMVALMAEATAKPMPPAAPHNALPRVLAFYHYWRKIYGPTFLIWFGPTPRLTVAEPEMVREIFLTRAEAFDRYEAHPVVRQLEGDGLVSLHGDKWAHHRRVLTPGFYPDNLNRLVPHVGRSVAALAERWRAMACAGGGEVEVDVAEWFQAVAEEAITRATFGRSYDSGRVVFRLQARLMAFASEAFRKVLVPGYRFLPTKKNRMSWGLDREIRRGLVRLIGRRSGGDGGEEDETTTELKDKQDSGFNDLLGLMINAGVDRTMPVEDMVEECKTFFFAGKQTTTNLLTWATVLLAMHPDWQDRARREVLAVCGDAAGELPTKDHLPKLKTLGMILNETLRLYPPAVATIRRAKFDVTLGGGGDGDAGGIHIPRDTELLVPIMAIHHDARLWGPDAAQFNPARFASGAARAAKHPLAFIPFGLGSRMCIGQSLAILEAKLTMAVLLQRFDLALSPTYVHAPTVLMLLHPQYGAPLIFRPRQSQPSN
Protein: GH21870p (Q8MR48)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
SVLLAAMRILPIVILTLMTVHSGCGKKQSKKEKDKGPCGKPYLRELNGKCFYVGIKKINWFGAQNNCLRKGLNLADVSTMEDFKAVVHYVTSQVGFDDFWFGGNDLQSEGRFKYISSGKLVRYMGDSNIVEPTQRSNLDDCLEIRIRPNVTVVLDVNCQEKKYFICEQNQMKCAVPAEDSGDGQKHSHEHLHHFHHDAGQKDKQETGIKEQSVESDSRPADNSNSTEIGVSKEKEAEGAPTPGDGGGTTEPVFENGMENAAEPIAEQEQTVPPGGTGPPAAADATGAATPAPDAAAAEGATPAAAPPAEGAPAAEAATPAPAAPEGEATPAPAA
Protein: Dimethylglycine dehydrogenase-like protein isoform 2 (Sarcosine dehydrogenase) (O96023)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASLSRALRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVAQGPSRPLPSTANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSVGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAQELLRRLPPR
Protein: short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) (E9PE82)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGPSLLGPTGPIFALGQVGCPCPSSAATEACTFPRSRQRVSRPELLREGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
Protein: Eukaryotic translation initiation factor 5A-2 (AtELF5A-2) (eIF-5A-2) (Protein FUMONISIN B1-RESISTANT 12) (Q93VP3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The precise role of eIF-5A in protein biosynthesis is not known but it may function as a bimodular protein capable of binding to both RNA and proteins. Regulates cytokinin-mediated root protoxylem specification and represses secifically the expression of AHP6. Regulates the induction of programmed cell death caused by infection with virulent pathogen.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24163315}. Nucleus {ECO:0000269|PubMed:24163315}.
Interaction partners:
- Deoxyhypusine synthase
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS6z
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein bL28c
- Small ribosomal subunit protein eS1z
- Large ribosomal subunit protein eL21z/eL21y
- Large ribosomal subunit protein eL21x/eL21w
Sequence:
MSDDEHHFEASESGASKTYPQSAGNIRKGGHIVIKNRPCKVVEVSTSKTGKHGHAKCHFVAIDIFTAKKLEDIVPSSHNCDVPHVNRVDYQLIDITEDGFVSLLTDSGGTKDDLKLPTDDGLTAQMRLGFDEGKDIVVSVMSSMGEEQICAVKEVGGGK
Protein: Probable endochitinase (EC 3.2.1.14) (Q11174)
Organism: Caenorhabditis elegans
Interaction partners:
- Beta-hexosaminidase A
- GH18 domain-containing protein
- N-acetyl-D-glucosamine kinase
- Cytochrome oxidase c subunit VIb
Sequence:
MLLGKFLLVASFILPIAYTWTGATIRNHPADVVAARNKITSRSVARSEPTNSYIRPCYFTNWAQYRQGRAKFVPEDYTPGLCTHILFAFGWMNADYTVRAYDPADLPNDWAGEGMYRRVNKLKVTDTQLKTLLSFGGWSFGTALFQGMAASSASRKVFIDSAITFVRTWGFDGIDIDWEYPSGATDMANYVALVKELKAACESEAGSTGKDRLLVTAAVAAGPATIDAGYDIPNLAPNFDFILLMSYDFFGAWASLVGFNSPLYATTELPAEWNGWNVDSSARYWNQKGMPKEKIIVGMPTYGRGWTLNNASAINPGTSGSPAKITQYVQEAGVGAYFEFCEMLANGATRYWDSQSQVPYLVQGNQWWSYDDEESFANKMAYVKREGYGGAFVWTLDFDDFNAGCSNSNGQLYPLISVIAKELGGVIIPKKGGVTTAPTTVATTVTTGRPPMTSAVTTTTAATTTTTRAATTTTASNTNVCSGKSDGFYPNSNNCGLFVLCLSSKSYSMSCPSGLQYSASLKYCTTSTASGCSVTTTRAPTTTTKSAPTVTTTTRAPTTTTPAFKCTKDGFFGVPSDCLKFIRCVNGISYNFECPNGLSFHADTMMCDRPDPSKCAK
Protein: Ubiquitin carboxyl-terminal hydrolase-like protein, putative (DUF627 and DUF629) (O80771)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMMKSTDESETKWKIDDAAELARDFWLERDGISALKLTEKTISDHGNHEKCSSHHELQGDIFYAQAKKTDDTDLKCLYLFASVDAYSMATLLSPNALTLRSFRGYARSLIKLGDQLRINKFYEKAVSKAKLGMSITSPQGKSTDGGYFTKIKTELQNWIDLATTKMQATVAVSDIGTMDNQKEPGEEDTSFDRLKKIWVKLDDKTKINFLVVDFEKLIGYIQDKHGTEVKEHFQKCIPIANNLRWRCWKCHICSQVNYCFTDCKMHILDNHVHNSEPDFSARPKCVDEILADMICCGDWKPVDTAEAENLIKDRAKRGEEFVYVNGWCSDWPEAKDRERENVLKQFAEVLKSSCAKENCTLSCTLWDWLRDYTEENLELPGVPGIYLDQCCFFKNPQCICFLDLKHLEHILKYFRQLTTDVRASLVPKVVNQFWENSQVKERIDLEGVATYNLLLDKRLLYEEELESDKIGTVEHYKSTGIFEDVMPKGDKIVSWILDCPEIDREFVSQMANGVHNSKLWLAALRIVRCVIRKKESYYDKRRKMLTYEKMLGEAETICDREDTRKNVNQRSTYESALRMKCEDLVGKQDDDTKCFLSVVRDVFERQSSPSFEVFEDKKCISELSSTVPNDDVKKSLLTLRKSLKEKFPLIDSKILQNKSTYEKLIDVFPKLSAVEYRLVVLPFVKKFLQDKLKKMMKTNSSSVAAGDSAERKPKKRHL
Protein: Tight junction protein 1 (H0YKB1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGRVTRTFENLKKIMILLSRKMCMCTYTQQLHTISGDSQGSIGHHLTHG
Protein: Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Q02769)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8509416}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Squalene monooxygenase
- Lanosterol 14-alpha demethylase
- Lathosterol oxidase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Geranylgeranyl pyrophosphate synthase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Ergosterol biosynthesis 28 homolog
- Farnesyl pyrophosphate synthase
- Methylsterol monooxygenase 1
- Lanosterol synthase
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
Protein: Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) (P27037)
Organism: Homo sapiens (Human)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P27038}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Bone morphogenetic protein 7
- Bone morphogenetic protein 6
- Growth/differentiation factor 11
- Inhibin beta A chain
- Activin receptor type-1
- Bone morphogenetic protein 2
- Bone morphogenetic protein receptor type-1A
- Growth/differentiation factor 2
- Activin receptor type-1B
- Activin receptor type-2B
Sequence:
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Protein: Ras-related protein Rab-21 (Q6AXT5)
Organism: Rattus norvegicus (Rat)
Function: Small GTPase involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35282}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P35282}. Early endosome membrane {ECO:0000250|UniProtKB:P35282}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35282}. Cleavage furrow {ECO:0000250|UniProtKB:P35282}. Cell projection, neuron projection {ECO:0000269|PubMed:19745841}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (PubMed:19745841). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (By similarity). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (By similarity). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:19745841}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- Ankyrin repeat domain-containing protein 27
- LOC691036 protein
Sequence:
MAAAGGGAAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQAGAARRGVQIIDDEPQAQSGSGGCCSSG
Protein: Prorelaxin 1 [Cleaved into: Relaxin B chain; Relaxin A chain] (P01347)
Organism: Rattus norvegicus (Rat)
Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
Subcellular location: Secreted.
Interaction partners:
- Relaxin receptor 1
- Relaxin-3/INSL7 receptor 1 long form.
- Insulin-like 3
- Relaxin-3
- Relaxin receptor 2
- Insulin-like peptide INSL6
- RLF zinc finger
Sequence:
MSSRLLLQLLGFWLFLSQPCRARVSEEWMDQVIQVCGRGYARAWIEVCGASVGRLALSQEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNLSEERKAALSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSDAQSRKKRQSGALLSEQCCHIGCTRRSIAKLC
Protein: Signal transducer and activator of transcription 1 (B5XD08)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- Signal transducer and activator of transcription
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Interferon regulatory factor
- RNA helicase
- Tyrosine-protein kinase
- Interferon regulatory factor 9
- Tyrosine-protein kinase
Sequence:
MAQWFQLQQLDSKYLEQVDQLYDDTFPMEIRQYLSAWIESHDWDMVATSVSLAAVRFHDLLAQLDIQYSRFALENNFLLQHNIRKIKRNLQDHFQEYPLQMAMIICNCLKEEKKILASIIKKEDNVGSTPNNMVLDKQKELDNNVKDLRNRVQDAEHEIKSLEDLQDEHDFKKKTLQSRVEQEVNGMAQLQAVRKEIREEEIVIRKMFIKLNITRGVVVNQISDILCLAEQIQFNLVTVEVPEWKHRQQIACIGGPPNACLDQLQIWFTAVAEGLQQVRQQLKKLQELEQKYTYENDPITQGKSALEERALTLFKYLIVK
Protein: Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53) (P89055)
Organism: Rotavirus sp
Subcellular location: Host cytoplasm, host cytoskeleton {ECO:0000256|HAMAP-Rule:MF_04088}.
Interaction partners:
Sequence:
MATFKDACYHYRKLNKLNGLVLKLGANDAWRPAPIAKYKGWCLDCCQHTDLTYCRGCALFHVCQWCSQYNRCFLDEEPHLLRMRTFRNQISRKDIEGLINMYNTLFPINERIVDKFISNVKQRRCRNEFLIEWYNHLLLPITLQALMVELEGDVYYIFGYFDHMEKENQTPFQFVNMINNYDKLLLDDKNFDRMTNLPVILQQEYAFRYFSKSRFISKTKKSVNRHDFANNLMEEMDNPISLMQVMRNCVNEYMDDKNWNEKCTLIVDMKSYMELMKSSYTEHYSVSQRCKLFTIYKLNIISKLIKPNYIFSNHGAHALDVHNCKWCQMNNHYKIWDDFRLKKVYNNTMCFIRALMKSNKNVGHRSSQEVVYEYMSNIFIVWKNEKWNKSMQMIFDYLEPVEISGIEYILLDHELSWEIRGIVMQIMNGEIPRILTFNDVKKIISAIIYDWFDVRYMREMPLIISTTNELRKMNKRNDLMDEYSYELSDTE