wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor-like protein EIX1 (EIX receptor 1) (Q6JN47)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Involved in plant defense. Confers resistance to the fungal pathogen T.viride through recognition of the EIX elicitor protein.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Ethylene-inducing xylanase
- Receptor-like protein EIX2
Sequence:
MDKWKYARLAQFLFTLSLLFLETSFGLGGNKTLCLDKERDALLEFKRGLTDSFDHLSTWGDEEDKQECCKWKGIECDRRTGHVTVIDLHNKFTCSAGASACFAPRLTGKLSPSLLELEYLNYLDLSVNEFERSEIPRFIGSLKRLEYLNLSASFFSGVIPIQFQNLTSLRTLDLGENNLIVKDLRWLSHLSSLEFLSLSSSNFQVNNWFQEITKVPSLKELDLSGCGLSKLVPSQADLANSSLISLSVLHLCCNEFSSSSEYSWVFNLTTSLTSIDLLYNQLSGQIDDRFGTLMYLEHLDLANNLKIEGGVPSSFGNLTRLRHLDMSNTQTVQWLPELFLRLSGSRKSLEVLGLNENSLFGSIVNATRFSSLKKLYLQKNMLNGSFMESAGQVSTLEYLDLSENQMRGALPDLALFPSLRELHLGSNQFRGRIPQGIGKLSQLRILDVSSNRLEGLPESMGQLSNLESFDASYNVLKGTITESHLSNLSSLVDLDLSFNSLALKTSFNWLPPFQLQVISLPSCNLGPSFPKWLQNQNNYTVLDISLASISDTLPSWFSSFPPDLKILNLSNNQISGRVSDLIENTYGYRVIDLSYNNFSGALPLVPTNVQIFYLHKNQFFGSISSICRSRTSPTSLDLSHNQFSGELPDCWMNMTSLAVLNLAYNNFSGEIPHSLGSLTNLKALYIRQNSLSGMLPSFSQCQGLQILDLGGNKLTGSIPGWIGTDLLNLRILSLRFNRLHGSIPSIICQLQFLQILDLSANGLSGKIPHCFNNFTLLYQDNNSGEPMEFIVQGFYGKFPRRYLYIGDLLVQWKNQESEYKNPLLYLKTIDLSSNELIGGVPKEIADMRGLKSLNLSRNELNGTVIEGIGQMRMLESLDMSRNQLSGVIPQDLANLTFLSVLDLSNNQLSGRIPSSTQLQSFDRSSYSDNAQLCGPPLQECPGYAPPSPLIDHGSNNNPQEHDEEEEFPSLEFYISMVLSFFVAFWGILGCLIVNSSWRNAYFKFLTDTTSWLDMISRVWFARLKKKLRRAR
Protein: Magnesium transporter NIPA4 (Ichthyin) (NIPA-like protein 4) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 4 homolog) (Q8BZF2)
Organism: Mus musculus (Mouse)
Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9JJC8}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein-glutamine gamma-glutamyltransferase K
- Hydroperoxide isomerase ALOXE3
- Omega-hydroxyceramide transacylase
- Glucosylceramide transporter ABCA12
- Lipase member N
- Ceramide synthase 3
- Long-chain fatty acid transport protein 4
Sequence:
MELRVANANGSCENGSIVSLYCSSQEVLCQIVRGISPEEPYNATLITWQERVRKKYGFYIGVGLAFLSCFLIGTSVILKKKGLIRLVATGATRAVNGGYGYLKDPMWWAGMATMSAGEVANFGAYAFAPATVVTPLGALSVLISAIFSSYCLGESLNLLGKLGCVICMAGSTVMVIHAPKEEKVTTVAEMASKMKDTGFIVFAVLLVVSCLILIFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQGLPVVRHPLPYILSLILGLSIIIQVNFLNRALDIFNTSLVFPIYYVFFTTVVVASSIVLFKEWYTMSAVDIVGTLSGFVTIILGVFMLHAFKDLDINQISLPHTHKNPTPAPAPEPTVIKLEDKNVLVDNIELASTPSPQQKPKVFMTDS
Protein: Cold shock-like protein CspLB (CspB) (P0A357)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit beta
Sequence:
MQTGTVKWFNSEKGFGFIEVEGGDDVFVHFSAIEGEGFKTLDEGQSVEFEIVEGQRGPQAEKVTKL
Protein: Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) (P36506)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P36507}. Membrane {ECO:0000250|UniProtKB:P36507}; Peripheral membrane protein {ECO:0000250|UniProtKB:P36507}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000250|UniProtKB:P36507}.
Interaction partners:
- Mitogen-activated protein kinase 1
- Dual specificity mitogen-activated protein kinase kinase 1
- Mitogen-activated protein kinase 3
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase A-Raf
- GTPase NRas
- Mitogen-activated protein kinase kinase kinase 1
- GTPase HRas
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 13
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQPSTPTRTAV
Protein: Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells) (Q99ML2)
Organism: Mus musculus (Mouse)
Function: May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway.
Subcellular location: Membrane {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12789265}.
Interaction partners:
- Cell division control protein 42 homolog
Sequence:
MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKRYRSGVKSKNWVYKILGGFAPEQKEIPPRSDSPLCFHEPEGGLKCLIPEGAVRRGELLGSGCFGVVHRGLWTLPSGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLPVALLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRMIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDRARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEAWLSEGRCVREVTEPGALRMEPGDPITIIEGSLDTATWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPAHRGSPAHGEKCRGGTDGDREKATLQDLPPARSHRTKMPLQRMRGISKSLESVLSLGPRPTGGGSSPPELRRTRAMPQRLPDLPPRPPDLPPRPPIICNSSQPTQPHKARPKRESSHNHRTGAPGASKATVPSGGPLSDPEWQRKVVEVELSVHGVTYQECQVALRTTGGDVASAIRNLKVDQLFHLSNRSRADCRRILEHHQWDLSAASRYILARS
Protein: PPM-type phosphatase domain-containing protein (Q5ZJW3)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAAQRRSLLQSEQQPSWTDDLPSCHLSGVGSAPNRSYSADGKGTEGHPLEDNWLKFRSENNCYLYGVFNGYDGNRVTNFVGQRLSAELLLGQLHADHSDADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPHHQLPPQYQKIVERLKVVEQEISGGAMAIVAVVLNNKLYIANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRFSQLGLDAGKIKQVGTIRGQESTRRIGDYKVKYGYTDIELLSAAKSKPIIAEPEIHGGHSLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIATEFAKQTSLDAVAQAVVDRVKRIHCDTFASGGERSKFCPRHEDMTLLVRNFGYPLGEVSQPTLTPTQGGRVYPVSVPYSSSQSTSKTSVTLSLVMPSQGQMVNGAHSSSTWMKPPPPSLTKAPL
Protein: Protein CROWDED NUCLEI 3 (Protein LITTLE NUCLEI 3) (Q9CA42)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (By similarity). Required for nucleus structure organization (e.g. size and shape).
Subcellular location: Nucleus membrane {ECO:0000250|UniProtKB:F4HRT5}; Peripheral membrane protein {ECO:0000250|UniProtKB:F4HRT5}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23396599}. Cytoplasm {ECO:0000269|PubMed:23396599}. Nucleus lamina {ECO:0000250|UniProtKB:F4HRT5}. Note=Recruited to the nucleus envelope (NE) by SUN proteins and is immobilised therein (By similarity). Punctate or bundle-like structures are detected, especially in trichomes where bundle-shape localization pattern along the long axis of the nucleus is observed. During prometaphase to anaphase, localized diffusely in the cytoplasm. Later transferred from the cytoplasm to the chromatin surface, preferentially assembling to the distal surface of the chromatin. Relocalized to the nuclear periphery during late telophase (PubMed:23396599). {ECO:0000250|UniProtKB:F4HRT5, ECO:0000269|PubMed:23396599}.
Interaction partners:
- Protein KAKU4
- WPP domain-interacting tail-anchored protein 1
- Paramyosin
- SUN domain-containing protein 1
- SUN domain-containing protein 2
- Nuclear pore complex protein NUP1
- Plant UBX domain-containing protein 4
- WPP domain-interacting tail-anchored protein 2
- Plant UBX domain-containing protein 3
- Nuclear envelope-associated protein 1
Sequence:
MFTPQRNRWPETDRKGKAIAFSDEIITPPPQRVLLREDDDWQKFKEVGLLDEASLERKDRDALIEKILKLEKELFDYQHNMGLLLIEKKQWTSTNNELQQAYDEAMEMLKREKTSNAITLNEADKREENLRKALIDEKQFVAELENDLKYWQREHSVVKSTSEAKLEEANALVIGMKEKALEVDRERAIAEEKFSVMNRKSSELERKLKEVETREKVHQREHLSLVTEREAHEAVFYKQREDLQEWEKKLTLEEDRLSEVKRSINHREERVMENERTIEKKEKILENLQQKISVAKSELTEKEESIKIKLNDISLKEKDFEAMKAKVDIKEKELHEFEENLIEREQMEIGKLLDDQKAVLDSRRREFEMELEQMRRSLDEELEGKKAEIEQLQVEISHKEEKLAKREAALEKKEEGVKKKEKDLDARLKTVKEKEKALKAEEKKLHMENERLLEDKECLRKLKDEIEEIGTETTKQESRIREEHESLRITKEERVEFLRLQSELKQQIDKVKQEEELLLKEREELKQDKERFEKEWEALDKKRANITREQNEVAEENEKLRNLQISEKHRLKREEMTSRDNLKRELDGVKMQKESFEADMEDLEMQKRNLDMEFQRQEEAGERDFNERARTYEKRSQEELDNINYTKKLAQREMEEMQYEKLALEREREQISVRKKLLKEQEAEMHKDITELDVLRSSLKEKRKEFICERERFLVFLEKLKSCSSCGEITENFVLSDLRLPDVEDGDKRFGKQKLKAEEALNISPSAENSKRTSLLGKIASKLLSISPIGKTDKVTDLGITVKLPESSQPDDSLDRVSGEDHEPSATEQSFTDSRIQEGPEGSLQSEMKSDKPRRGRGRGRGRGKSVRGRSQATKAVSRDSKPSDGETPRKRQREQTSRITESEQAAGDSDEGVDSITTGGRRKKRQIAVPVSQTPGQTRYQLRRHRNVGTEEDKAQASKGATEKQERVNDDIRKVPSPKETRTPPEGENRENGKAEVLVETVTHEEIVTVETETVFKVNNTGKNPVEDPQLEVGGSGEIREHGEEDDENISMIEEENEGEEEEETERQGNDASIGKKIWVFFTT
Protein: Uncharacterized protein C4G9.14 (Q10244)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFIAKSIVIGLLICVLFFFFFVSRFNDKYELQPLLTLGLLNASLTALSDLLAQALDSYKLLKFRNKRDVSLEKYGNTILLPASTSKLDVHRTIRYAAYGLCLTPIQFRWFVALSNVIQTENPFIAIVLRVALDQFIFAPLGIVFFFLFMGITECKSYERLKSYFRKHYWPTLKANYILWPAVQLFNFTFVPLVLQVIFANAVSMVWTAYLSLKNSSPNADV
Protein: NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (F1SFQ0)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLETCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRISYNCMWTGLYHSQKMDKWHADISSKL
Protein: Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Q3LS21)
Organism: Mus musculus (Mouse)
Function: pH-dependent, voltage-insensitive, background potassium channel protein.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28630209, ECO:0000269|PubMed:30416196}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000305|PubMed:28630209}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:30416196}. Note=Colocalizes with MAP2 in the soma and proximal dendrites of dentate gyrus granule cells. {ECO:0000269|PubMed:30416196}.
Interaction partners:
- Potassium channel subfamily K member 3 channel) channel 1)
- Potassium channel TASK2
- Potassium channel subfamily K member 10
- Potassium channel subfamily K member 18
Sequence:
MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQAKGALQRKPFYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEELLEGEVAEILAGNPRRVSVRAPQRRKRHHAMYFLRKYGRTLCYLCFPGTNWGKDDDDDDDDDVVDNVVVTAPISAPAPAPAPAPAPAAVAAGATIRSVRATVHTVSCRVEEIPPDVLRNTYFRSVFGAIPPGMHTCGDHRLHLRRKSI
Protein: Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) (P20711)
Organism: Homo sapiens (Human)
Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
Interaction partners:
- Tyrosine 3-monooxygenase
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- Dopamine beta-hydroxylase
- Phenylalanine-4-hydroxylase
- Catechol O-methyltransferase
- Tryptophan 5-hydroxylase 1
- Transmembrane O-methyltransferase
- Tryptophan 5-hydroxylase 2
- Diamine oxidase [copper-containing]
Sequence:
MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
Protein: Dynein assembly factor with WD repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) (Q8N136)
Organism: Homo sapiens (Human)
Function: May play a role in axonemal outer row dynein assembly.
Subcellular location: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q3Y8L7}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q3Y8L7}. Note=Expression is concentrated at the flagellum basal body but is also detected along the length of the flagellum. {ECO:0000250|UniProtKB:Q3Y8L7}.
Interaction partners:
- Intraflagellar transport protein 46 homolog
- U4/U6 small nuclear ribonucleoprotein Prp3
- Pre-mRNA-processing factor 6
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- U4/U6 small nuclear ribonucleoprotein Prp31
- Pre-mRNA-processing-splicing factor 8
- U4/U6.U5 tri-snRNP-associated protein 1
- U6 snRNA-associated Sm-like protein LSm8
- U6 snRNA-associated Sm-like protein LSm7
- Microfibrillar-associated protein 1
Sequence:
MKLKSLLLRYYPPGIMLEYEKHGELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR
Protein: Uncharacterized protein (Q57Z65)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASLQLGKSTVTRGSGHEVGNQTMGVEPVLSHHVWTCGRGTSKNTPLNTQPSFQEESPPVTNDRIKAEPTTESPRKHGVTKHTPGGEQVSGSPDHTAPDGRASTLPPSECCSSPNGLHPEAKDEDPPTLTTAALPTAILSRENLLIETAKQQRELQWYKDRCREQEVALCAVNEKQAVLEDALIGARIAALNEKERRREFVAMAAAQRREARLALEPQVHALRVMEGELGGLRRELRHTRKLLEQSEKERVALTECKGRYEAELGKLRNVNERIHGELKVMHSRCAKLEQVNAKNIEVVDAEACEVKQSKNTATTDVDDEHRREVDATLHITFLQLYEEMERRQLEAAAVREVFEVYVDYLHRIQRETCGTMLLLCKHGKQLVNTLTRSDASLSDGGCPDDGEVGGSCAYTTLLRCANEVGKQLQAIETAIGDQLLTATQQQRDMQNLLLTERRTHQDELRNIEQTLQTVRQGAEDMKEKLTIADCRYNQLAQAVKRHCRQLLSVSAKGSKNKSKSGNSKQERKLSENSAEREVTAVRKIGDLLTIEGKGNNSVSPQVASPAELLNPAKLLLGDVPSSGGEIESLLALLKTSQQAACCALEDMRETLDSNEAQWQKERQRLIAATTEVRQRHQATTKRFQASLTAARATEVDLEKKLSAAVVERKVAVKKAEIAEMELQSFGKRHRQLQQELQAMKEDCELQRKEVGNRTKDIDALREQLTERREEHFEMAVLRGRCDDLVRITDALEQRVQREEKGKHALYEVARCFCGVLIAVVMRVRTVVAERRAMCRAYEAATEECRSMMLELRDTIKDIKVEETRRKESKRLAPFIYHPSFFAVATVSIACTRMSRATKRSRRPRRVSFELHDSHADGQDDDGASRLSVPACGKVFAPPNSLRGVVESVPLLSELFRRPFLTNIVRTVQIPPLRDLLPIIVGIYEKNNTVGSTYLLQQVIDIAEVDVASNEYRAHFAPSMTPSWKTDPSKWVRVGKQYCGRSCSGPSKMAPAQRLREVFHFLRHRIDKLKREQEKHKEAMCGALEENRQLRAQLEESQQMATSLLRKQEEYELEAAVSSAARGACRGVDQRLSELYDELHKEREARRVVEEVNAQLRMREVELLASSHKMRDEVRSLSIELAEQQQSYTTDRLNHSSCNYSHRPAAAAEHSKPLYHPRSVCLSGVELPYTSAQ
Protein: Cytosolic iron-sulfur assembly component 2B (MSS19-interacting protein of 18 kDa) (Mitotic spindle-associated MMXD complex subunit MIP18) (Protein FAM96B) (Q9Y3D0)
Organism: Homo sapiens (Human)
Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:29848660}. Midbody {ECO:0000269|PubMed:29848660}. Note=In mitosis, localizes to the spindle during metaphase and the spindle midbody during telophase (PubMed:29848660). Co-localizes with KIF4A to the spindle midzone and midbody during telophase and cytokinesis (PubMed:29848660). {ECO:0000269|PubMed:29848660}.
Interaction partners:
- MMS19 nucleotide excision repair protein homolog
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
- ADP/ATP translocase 2
- Cytosolic iron-sulfur assembly component 3
- General transcription and DNA repair factor IIH helicase subunit XPD
- Cytosolic iron-sulfur assembly component 2A
- ADP/ATP translocase 3
- Regulator of telomere elongation helicase 1
- Cytosolic Fe-S cluster assembly factor NUBP1
- F-box/LRR-repeat protein 5
Sequence:
MVGGGGVGGGLLENANPLIYQRSGERPVTAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS
Protein: Putative S-ribonuclease binding protein SBP1 (RING domain protein) (SBP (S-ribonuclease binding protein) family protein) (Q84JF9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine carboxypeptidase-like 8
Sequence:
MLSGNNGNTAPPVFMNENQLQYQTNLRSNQLHLLGNMGGGCTVDPVNYFANDNLVPMIRPNKRGREAESISNNIQRQQQKLQMSLNYNYNNTSVREEVPKENLVSTGLRLSYDDDEHNSSVTSASGSILAASPIFQSLDDSLRIDLHRQKDEFDQFIKIQAAQMAKGVRDMKQRHIASFLTTLEKGVSKKLQEKDHEINDMNKKNKELVERIKQVAMEAQNWHYRAKYNESVVNVLKANLQQAMSHNNSVIAAADQGKEGFGDSEIDDAASSYIDPNNNNNNNMGIHQRMRCKMCNVKEVSVLIVPCRHLSLCKECDVFTKICPVCKSLKSSCVQVFFS
Protein: Steryl acetyl hydrolase 1 (EC 3.1.1.-) (P53324)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the deacetylation of acetylated sterols. Involved in the resistance to eugenol and pregnenolone toxicity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18034159}; Single-pass type II membrane protein {ECO:0000269|PubMed:18034159}.
Interaction partners:
- Alcohol O-acetyltransferase 2
- Uncharacterized protein YPR084W
- Acyl carrier protein, mitochondrial
- RNA polymerase I-specific transcription initiation factor RRN11
Sequence:
MAANSGLDSKVEYYRLQENEIISAVSSEDADQNDAGFRLSTIHLHLFHGLKFAALLFTVVPVFIILDSMKIIFQRKRRFCLDHVNRSFLRQSSWILDERICQYVLNPLFVCLYPSTFSSPTYVKCNIPIEDQKSPENNIFQDHQLNAPKIVSTKFYQYVMPEGFDPTTDPVLVFYHGGGYALKLTPTSFSFLNNMRNAFPKMAILVPDYTVTATDDQSKKYPLQILQNVAIFDYVVKTMGCKNVVIMGDSAGGNAVLNIVLYLRKCHREIYPKKVIAISPWANATFFHEGEKEYMQGTQEWDGLCLKSHSMFGRMFVGNNPNVDFTSDPFVNIEKNFETKMWQDILKKCSVMITYGSDELLSFQNKILAKKMSDASEGCNHFTAKNVLVEHQGYHTGPILNYSRNMDRWTNIPSIARILEFMQS
Protein: Protein ABIL1 (Abl interactor-like protein 1) (AtABIL1) (Q8S8M5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Protein NAP1
- Protein BRICK 1
- Actin-related protein 2/3 complex subunit 3
- Protein PIR
- Dirigent protein 16
- Dirigent protein 18
- AT3G19900 protein
- BTB/POZ domain-containing protein At3g19850
- BTB/POZ domain-containing protein At1g50280
- Actin-related protein 2
Sequence:
METEISGMDNPAMTLDEVSMERNKSFVKALQELKNLRPQLYSAADYCEKSYLHSEQKQMVLDNLKDYTVKALVNAVDHLGTVASKLTDLFDHQNSDISTMEMRASCVSQQLLTCRTYIDKEGLRQQQLLAVIPLHHKHYILPNSVNKRVHFSPLRRTDTRQNHYQAISRLQPSDAPASKSLSWHLGSETKSTLKGTSTVAPSSKDSKAFSKTSGVFHLLGDDENIANKKPLAGSQVSGVPAASTAHKDLEVPKLLTAHRSLDNNPRREIIQAPVRTKSVLSAFFVKQKTPKLKAGYVS
Protein: C-type lectin domain family 4 member G (Q8BNX1)
Organism: Mus musculus (Mouse)
Function: Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6UXB4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6UXB4}.
Interaction partners:
- C-type lectin domain family 1 member B
Sequence:
MNTGEYNKLGSAIEEVSRGQLGRWECYKQRLFFLVLALLVATVLWALILSTLLSSASSKLRVLLSHQDLLRTNASEQKMTLSSLKDDIGACRNCCSVTKAQLQTTLAEFKDIQAKLMEQESILKELQERVTQDLAKASRDRENIRSELFQALEAVKRQNSSCEQCPPSWLPFQGSCYYFSETQATWDTAQSYCGGQGAHLVIVRGLNEQGFLSQHTRGRGYWLGLRAVRHLNKIQGYRWVDGASLNFSHWNSGEPNDSRGHEDCIMMLHSGLWNDAPCTNERDGWICEKRSSCY
Protein: Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Q08890)
Organism: Mus musculus (Mouse)
Function: Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.
Subcellular location: Lysosome {ECO:0000269|PubMed:15149955}.
Interaction partners:
- Alpha-L-iduronidase
- Heparanase
- Inactive heparanase-2
- Formylglycine-generating enzyme
Sequence:
MSPPPPPPIWRQLSFSLLLGSFCIALESAAQGNSATDALNILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSVLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPEDFQRKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAKYSNFDVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVSLFPTLAGLAGLPVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAYSQYPRPADFPQWNSDKPSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGELYFVDSDPLQDHNVYNDSQHGGLLHSLRP
Protein: 26S proteasome non-ATPase regulatory subunit 3 homolog B (26S proteasome regulatory subunit RPN3b) (AtRPN3b) (26S proteasome regulatory subunit S3 homolog B) (Q9LQR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome non-ATPase regulatory subunit 1 homolog B
- 26S proteasome non-ATPase regulatory subunit 1 homolog A
- 26S proteasome regulatory subunit 8 homolog A
- 26S proteasome non-ATPase regulatory subunit 12 homolog B
- 26S proteasome regulatory subunit 4 homolog B
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 6A homolog A
- 26S proteasome regulatory subunit 6A homolog B
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
Sequence:
MTQDVEMKDNQTPTQSVVSAPTSTLQNLKEIAALIDTGSYTKEVRRIARAVRLTVGLRRKLTGSVISSFLDFALVPGSEAHTRLSSFVPKSDEHDMEVDTASSNSQAPPKHLPAELEIYCYFIVLLFLIDQKKYNEAKVCSTASIARLKSVNRRTVDVIASKLYFYYSLSYELTNDLAEIRSTLLALHHSATLRHDELGQETLLNLLLRNYLHYNLYDQAEKLRSKAPRFEAHSNQQFCRYLFYLGKIRTIQLEYTDAKESLLQAARKAPVASLGFRIQCNKWAIIVRLLLGEIPERSIFTQKGMEKTLRPYFELTNAVRIGDLELFGKIQEKFAKTFAEDRTHNLIVRLRHNVIRTGLRNISISYSRISLQDVAQKLRLNSANPVADAESIVAKAIRDGAIDATIDHKNGCMVSKETGDIYSTNEPQTAFNSRIAFCLNMHNEAVRALRFPPNTHREKESEEKRREMKQQEEELAKYMAEEDDDDF
Protein: Seminal fluid protein 24Bb (B4ZJ91)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Accessory gland-specific peptide 57Da
- GEO13347p1
- ACP24A4
- Seminal fluid protein 60F, isoform A
- Accessory gland-specific peptide 57Db
- Accessory gland-specific peptide 57Dc
- HDC01001
- Seminal fluid protein 96F
- FI11009p
- Ejaculatory bulb-specific protein 2
Sequence:
MKFVILLSLMCIGIGYAQQQSEVKCFMDAIPVGECGSRIIGYSYSSVRARCVNYETIGCEVIGNFFTDRKVCEAKCKPPISFRNNPFSYYFERAFNQARDTLRRIFNLPQ
Protein: LysM and putative peptidoglycan-binding domain-containing protein 3 (Q7Z3D4)
Organism: Homo sapiens (Human)
Function: Essential for Golgi structural integrity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29851555}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:29851555}.
Interaction partners:
Sequence:
MAGRHQNRSFPLPGVQSSGQVHAFGNCSDSDILEEDAEVYELRSRGKEKVRRSTSRDRLDDIIVLTKDIQEGDTLNAIALQYCCTVADIKRVNNLISDQDFFALRSIKIPVKKFSSLTETLCPPKGRQTSRHSSVQYSSEQQEILPANDSLAYSDSAGSFLKEVDRDIEQIVKCTDNKRENLNEVVSALTAQQMRFEPDNKNTQRKDPYYGADWGIGWWTAVVIMLIVGIITPVFYLLYYEILAKVDVSHHSTVDSSHLHSKITPPSQQREMENGIVPTKGIHFSQQDDHKLYSQDSQSPAAQQET