wanglab/gogpt-training-data huggingface dataset:
Protein: Pectinesterase PPME1 (AtPPME1) (PE PPME1) (EC 3.1.1.11) (Pectin methylesterase 9) (AtPME9) (Pectin methylesterase PPME1) (Protein POLLEN SPECIFIC PME 1) (Q84WM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin. Involved in the pollen tube growth and determination of pollen tube morphology.
Subcellular location: Endoplasmic reticulum. Golgi apparatus. Secreted, cell wall.
Interaction partners:
- Pectinesterase inhibitor 2
- Pectinesterase inhibitor 1
- Pectin lyase superfamily protein
- At1g10770
- Expansin-B5
- Pentatricopeptide repeat-containing protein At3g18020
- Cellulose synthase-like protein D1
- Probable galacturonosyltransferase 13
- Proline-tRNA ligase
- Probable pectate lyase 3
Sequence:
MGYTNVSILLGLLMVFVTPMVFADDVTPIPEGKPQVAQWFNANVGPLAQRKGLDPALVAAEAAPRIINVNPKGGEFKTLTDAIKSVPAGNTKRVIIKMAPGEYKEKVTIDRNKPFITLMGQPNAMPVITYDGTAAKYGTVDSASLIILSDYFMAVNIVVKNTAPAPDGKTKGAQALSMRISGNFAAFYNCKFYGFQDTICDDTGNHFFKDCYVEGTFDFIFGSGTSMYLGTQLHVVGDGIRVIAAHAGKSAEEKSGYSFVHCKVTGTGGGIYLGRAWMSHPKVVYAYTEMTSVVNPTGWQENKTPAHDKTVFYGEYKCSGPGSHKAKRVPFTQDIDDKEANRFLSLGYIQGSKWLLPPPAL
Protein: Protein kinase domain-containing protein (Q387B8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSVRLLLGQVMHITPSSVIFSADEVDTLDFQTVSTIPKAHRDFVQKNGLIAKVMLSVTSKITSWSTREERQKIWWDALTSTGLVRSKATTVEVPTNLSGVFWPIIDDEQLMIYADAAIKRHANLKLNECPYVVPVLYAQQIFYKCQEVKGTLCVVWMPKCRYNLAHWTKVQVPRRFIPESVLYKLIYDITNALIFLRDVCVEYPACISMEDILVGGVSDAEPSFLLNTLTSRPTCNQSEANSRSSSTVLFAPELLIQPCKLLTNSACNVWSLGMIAYQIASGLPSEESKAHLMGTRHAAGEMMLNHYRLKPSDVVLRVRAVLQAGSYNNPFIHLLLLMLGQDPHTRPTPYVVYEMLRDIMRFKPVIRFPFAIGPFTLVHLWSDDKIAVDPVQRRYDTEATCIVCNESRSNLMCGDNEHTSALCSPLWSAEEPLPGYAVARETSMTYLYPMLGRLDKKAQRRYIDAALRGDKMNRGSLLQLLGGFALLKPNEGKSAVAHDVMIPLPNGVLHKDEKVAVAAELNFTAALPWPSQCTFKLQQEGRIQWSIPGLFGFSNARWYAWILPGEKLELNGEPWVPAPDGAFVFWFNESLQPSEYDRYFVVCSVLSLTWQAKMKSNVLPDHVFKRKGDVGGLTPSNGSEGGFSSCTTSHNGEGSAERHSKKDVDGVNKSGRSALGQRSVNSLLNLPKVGDLQCTKGDGILPARRQVSSTANTTSSSSNSCDSDNSNPNHRRPPRRGSAVVRMDYVDDVVPDMIFDGTGETNSKGQPLQPQQRNGVTGHRSNSTEGIISVLHRSEDGMACSTPREPTYPRERPQGRHINPQPTEPTANPRPPPPNNSPGRRQRHEGEGKFGRLPSGMVTTPTLSKSPSGSRFSGRPSSPSAADVNRTLSPKESAVLQQSKTGFPLQSPPLRVFGRWHPPRHIDAPFQSLTFCTSSTAEHGTLSPPVMLSMGVRTALHAPAAATHMAFAANIMPLVRRNHPKSSAALVVKENNARDIIPHHGLVFYDEKEEVVGLLALRFALTRSPDITTGEMLLPIRLLPPVVATAAFNAQLNAAYFTGNAVFHSITRVGSESEVLRHSESLQHLGNFETLSPLSKKLTLSGARFGASDDPPHKVVCGDDDVLPFCWIGFENQSRMLMISDVHRLSWYPLYFTDE
Protein: Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 5) (mCLCA5) (Q8BG22)
Organism: Mus musculus (Mouse)
Function: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15284223}; Single-pass type I membrane protein {ECO:0000269|PubMed:15284223}. Basal cell membrane {ECO:0000269|PubMed:15284223}; Single-pass type I membrane protein {ECO:0000269|PubMed:15284223}. Cell junction {ECO:0000269|PubMed:15284223}.
Interaction partners:
Sequence:
MTHRDSTGPVIGLKLVTLLFTLSPELLFLGAGLKLKENGYDGLLVAINPRVPEDLKLITNIKEMITEASFYLFNATKRRVFFRNVQILVPATWTDHNYSRVRQESYDKANVIVAEQSEEHGDDPYTLQHRGCGQEGRYIHFTPSFLLNDELAAGYGARGRVFVHEWAHLRWGVFDEYNNDKPFYVNGRNEIQVTRCSSDITGVFVCEKGLCPHEDCIISKIFREGCTFLYNSTQNATGSIMFMPSLPSVVEFCNESTHNQEAPNLQNQVCSLRSTWDVITASSDLNHSLPVHGVGLPAPPTFSLLQAGDRVVCLVIDVSRKMAEGDRLLRLQQAAELYLMQVVEAHTFVGIVTFDSKGEIRASLQQIYSDDDRKLLVSYLPTAVSTDAETNICAGVKKGFEVVEERNGRADGSVLILVTSGADEHIANCLLTSMNSGSTIHSMALGSSAARKVGELSRLTGGLKFFIPDKFTSNGMTEAFVRISSGTGDIFQQSLQVESVCETVQPQHQLADTMTVDSAVGNDTLFLVTWQTGGPPEIALLDPSGRKYNTGDFIINLAFRTASLKIPGTAKHGHWTYTLNNTHHSPQALKVTVASRASSLAMSPATLEAFVERDSTYFPQPVIIYANVRKGLHPILNATVVATVEPEAGDPVVLQLLDGGAGADVIRNDGIYSRYFSSFAVSGSYSLTVHVRHSPSTSTLALPVPGNHAMYVPGYITNDNIQMNAPKNLGHRPVKERWGFSRVSSGGSFSVLGVPDGPHPDMFPPCKITDLEAMKVEDDVVLSWTAPGEDFDQGQTTSYEIRMSRSLWNIRDDFDNAILVNSSELVPQHAGTRETFTFSPKLVTHELDHELAEDAQEPYIVYVALRAMDRSSLRSAVSNIALVSMSLPPNSSPVVSRDDLILKGVLTTVGLIAILCLIMVVAHCIFNRKKRPSRKENETKFL
Protein: Transition state regulatory protein AbrB (P08874)
Organism: Bacillus subtilis (strain 168)
Function: Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription.
Interaction partners:
- Stage 0 sporulation protein A
- HTH-type transcriptional regulator SinR
- Global transcriptional regulator CodY
- RNA polymerase sigma-H factor
- Competence transcription factor
- TasA anchoring/assembly protein
- Protein SinI
- Signal peptidase I W
- Sporulation initiation phosphotransferase F
- Uncharacterized protein YveK
Sequence:
MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEKIILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK
Protein: Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11) (Q8BWY7)
Organism: Mus musculus (Mouse)
Function: Functions as a cellular zinc transporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24089422}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:24089422}. Cytoplasm {ECO:0000269|PubMed:24089422}. Golgi apparatus {ECO:0000269|PubMed:21702047}.
Interaction partners:
- Zinc transporter ZIP9
- Zinc transporter SLC39A7
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter 7
- Zinc transporter ZIP1
- Zinc transporter 6
- Zinc transporter ZIP3
- Zinc transporter ZIP13
- Zinc transporter ZIP12
- Proton-coupled zinc antiporter SLC30A5
Sequence:
MLQGYSSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGATEDPQTALALNLDPALMKKSDPRDPTSLLFPESELSIRIGSTGLLSDKRENGEVYQRKKVAATDLAEGVAPSGSMHGSSGQPGGSSWRRIALLILAITIHNIPEGLAVGVGFGAVEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASWASILGFVVMMSLDVGLG
Protein: RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) (Q9NTZ6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:9853615}.
Interaction partners:
Sequence:
MAVVIRLQGLPIVAGTMDIRHFFSGLTIPDGGVHIVGGELGEAFIVFATDEDARLGMMRTGGTIKGSKVTLLLSSKTEMQNMIELSRRRFETANLDIPPANASRSGPPPSSGMSSRVNLPTTVSNFNNPSPSVVTATTSVHESNKNIQTFSTASVGTAPPNMGASFGSPTFSSTVPSTASPMNTVPPPPIPPIPAMPSLPPMPSIPPIPVPPPVPTLPPVPPVPPIPPVPSVPPMTPLPPMSGMPPLNPPPVAPLPAGMNGSGAPMNLNNNLNPMFLGPLNPVNPIQMNSQSSVKPLPINPDDLYVSVHGMPFSAMENDVRDFFHGLRVDAVHLLKDHVGRNNGNGLVKFLSPQDTFEALKRNRMLMIQRYVEVSPATERQWVAAGGHITFKQNMGPSGQTHPPPQTLPRSKSPSGQKRSRSRSPHEAGFCVYLKGLPFEAENKHVIDFFKKLDIVEDSIYIAYGPNGKATGEGFVEFRNEADYKAALCRHKQYMGNRFIQVHPITKKGMLEKIDMIRKRLQNFSYDQREMILNPEGDVNSAKVCAHITNIPFSITKMDVLQFLEGIPVDENAVHVLVDNNGQGLGQALVQFKNEDDARKSERLHRKKLNGREAFVHVVTLEDMREIEKNPPAQGKKGLKMPVPGNPAVPGMPNAGLPGVGLPSAGLPGAGLPSTGLPGSAITSAGLPGAGMPSAGIPSAGGEEHAFLTVGSKEANNGPPFNFPGNFGGSNAFGPPIPPPGLGGGAFGDARPGMPSVGNSGLPGLGLDVPGFGGGPNNLSGPSGFGGGPQNFGNGPGSLGGPPGFGSGPPGLGSAPGHLGGPPAFGPGPGPGPGPGPIHIGGPPGFASSSGKPGPTVIKVQNMPFTVSIDEILDFFYGYQVIPGSVCLKYNEKGMPTGEAMVAFESRDEATAAVIDLNDRPIGSRKVKLVLG
Protein: At4g14930 (Expressed protein) (Survival protein SurE-like phosphatase/nucleotidase) (Q8LAM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEIDGGDRISGERPIIMVTNDDGIDAPGLRSLVRVLVSTNLYDVRVCAPDSEKSAVSHSIIWSRPLTAKRVEIDGATAYSVDGTPADCTGLGLSEALFPSRPDLVLSGINVGSNCGYNIVYSGTVAGAREAFLYDVPSASISYDFDWKRGEMNANDFALSAQACLPIINGILGAIKNKTHPMQCFLNIDLPTDIANHKGYKLTRQGKSMGKMGWRQVEEEAQGPKMLSTMTMDTESGVVSSENDTSAHAGKDSRLFKRELRASISEEGSDSHYLKEGFITVTPLGALSQTDVDCQNYYKEWLPKITNQSCSSSSL
Protein: 3',5'-cyclic-nucleotide phosphodiesterase 2 (PDEase 2) (EC 3.1.4.53) (High-affinity cAMP phosphodiesterase) (P06776)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Controls the level of cAMP in yeast cells, together with the low-affinity cAMP phosphodiesterase (PDE1).
Interaction partners:
- 3',5'-cyclic-nucleotide phosphodiesterase 1
- Adenylate cyclase
- cAMP-dependent protein kinase type 3
- Ras-like protein 2
- cAMP-dependent protein kinase type 2
- cAMP-dependent protein kinase type 1
- cAMP-dependent protein kinase regulatory subunit
- Adenosine kinase
- Inhibitory regulator protein IRA2
- Adenylate kinase
Sequence:
MSTLFLIGIHEIEKSQTIVQNEHYFDRVIELQDLDSLMVALYKDRVSPFPNVHNFETGVSIVLYDPSKFQLSVRQLDVLFKRFFPSFNISAIDHTREENLQRLECVERENSICRNRITRINHWMYHHHDDTPDGINKNSYGTVNGNSVPTQACEANIYTLLLHLNDSKAQHLRKASVPRLIRNIEFMSFLSDPIEKISQEGSHYWNILSTWDFCALSLSTQELIWCGFTLIKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAIDVMQATWRLCTYLLKDNPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHRELFQQLLSEHWPQLLSISKKKFDFISEAILATDMALHSQYEDRLMHENPMKQITLISLIIKAADISNVTRTLSISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDIIKDHPHIPNGQIFFINTFAEVFFNALSQKFSGLKFLSDNVKINKEYWMKHKKPQ
Protein: Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) (Q9CQR4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17045243, ECO:0000269|PubMed:17704541, ECO:0000269|PubMed:19405909}. Mitochondrion {ECO:0000269|PubMed:19405909}. Nucleus {ECO:0000269|PubMed:17045243, ECO:0000269|PubMed:17704541}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17045243}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000269|PubMed:17045243}.
Interaction partners:
- Phosphatidylcholine transfer protein
- Acyl-coenzyme A thioesterase 11
- Cytosolic acyl coenzyme A thioester hydrolase
- Acyl-coenzyme A thioesterase 8
- Acetyl-coenzyme A thioesterase
- Tyrosyl-DNA phosphodiesterase 2
- Acyl-coenzyme A thioesterase 3
- Acyl-coenzyme A thioesterase 9, mitochondrial
- Dyslexia-associated protein KIAA0319 homolog
- Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Sequence:
MSSMTQNLREVMKVMFKVPGFDRVLEKVTLVSAAPEKLICEMKVEEQHTNKLGTLHGGLTATLVDSISTMALMCTERGAPGVSVDMNITYMSPAKIGEEIVITAHILKQGKTLAFASVDLTNKTTGKLIAQGRHTKHLGN
Protein: Histone acetyltransferase GCN5 (Q8IB67)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcriptional coactivator ADA2
- PI3K/PI4K catalytic domain-containing protein
- SANT domain-containing protein
- Histone H4
Sequence:
MDYLIRNNEYCNVLYDGNELLRKRKINFDNEICPYKMNYWNNYNNNINIDNDNMNNEIVNEEFENTYNNINNNMYYLLGKEDMDEPRLCNKKRNVYNENFKNNLEYDENVNNYDNDNSSNISYKFINNECDKMKKSGEGTQENNDNENNNNDESNNNNNNNNNESNNNNNNNESNNNNNNNNNNESNNNNNNNESNNNNHGNNNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDKNEDDENTTGKGKKTEVKKRAGRKRNDSTMYANSNTMLKNNFLQNNKMIYNNMDHINDTNEQDKFLYEQRKMMMNNKMENMGPNMNMTNKNYFQTVNNMKMNVENNKNLIGINTNNMNNYQNNINSINTNMNIPKNKNLHSNKQMMFMNNNMNIHGKTNKLNDMARMNSINFNEENKMSVMNDDTRMDNKMRDIMKSGGMEVHLKNEESLYMNNMYNMNSNNPNNIPRISTMNIAKPMNNFNNMNMPINNMNAYNNHMINSYNNMMMTNNMNNINNINNINHINNNNNSNNNNNSNNSNNNINFGQHIQGVQFMNPNMNNDMNSNMNNINNNQMFLNNNQNNAHVHMVNNMNLNPSGNNSFFNNSNKHLNMMTMSSKNKKNAILKNTENNEFENIKRVHSNSSNYNNNNNNNSDSNNKKSIKMNSNENNNTTTTIIKNIRVENIKFNESVNLKNIDGLDLSTNFVNGKYISKLNNDEKIYNVVHSIVKDSLKDCLVDFYNNANYIFKDKLDFVCNSNTPTCNNINDLEDNKKDDGHVDKQNYSLEKKDNEEHTNNNSDPIMDGVELDVKKISEKKEDQIEKDKPKNDNTKNDNTKEDKNQNDDNKTNTSIPKTPKNEVKNVITSSLLSSFNIFSAFSNSNTPNSKKNKYDEEEEKEEKEEEEENNKCNDKDDEDKNKSPQNEDNKNITNDNNDNNNNNVDKENNLKESIDNLGNVDTDNNIKRDVLNYNNIEENEQSREYILIEITKSICSIINLQQLMPVNTRLANPNLIYDPNYETIYSKWKTFLRKEQSSGNLISNCFSRDFLHTILLCNYVTIIEDLRKTAVKKKLKYFFLHLCLESGISINVALMLFINATKQSDKLQSLLPSETGLGYLHRDAGGAKEENMGIITFECITNDREPDHLIKLITLKNIFSRQLPKMPREYIVRLVFDRNHYTFCLLKKNTVIGGVCFRPYFEQKFAEIAFLAVTSTEQVKGYGTRLMNHLKEHVKKFGIEYFLTYADNFAIGYFRKQGFSQKISMPKERWFGYIKDYDGGTLMECYIFPNINYLRLSEMLYEQKKAVKKAIHFIKPQVIYKGINYFADNKGAALHPSTIPGLLEVGWKKETREITKKVQHKEVQLKDQILGVLDYLEKQQSAWPFLKPVSLSEAPDYYDIIKEPTDILTMRRKARHGDYKTKEDFGIELKRMFDNCRLYNAPTTIYFKYANELQTLIWPKYEAITDTAK
Protein: Syntaxin 16 (Q9VR90)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
- HL02043p
- LD27967p
- Vacuolar protein sorting-associated protein 45
- LD34211p
- Syntaxin 8
- Alpha-soluble NSF attachment protein
- FI04457p
- Vesicle-associated membrane protein 7
- LD03592p
- Syntaxin-18
Sequence:
MTSRNLTEVFVIMRNNASKNRNHYDDRRGSDAERLLKHSVREAEEGLELQDDYGTPPAWLDKFEEAQYTMSKIKPKLDELGSLHARHLLRPAFDDQRDDECDIEVLSQIVSKLITSTHRHIQCVRSSIGVGSKMEQCLTVNAVHCALLQLQELTVKFRASQNAYLLQLNSREERSQKYFDDGGGAGAGDVFTNVELGEQSAENFVDSFDNFLQPPAEGKSGNGYLFEDDEQAIDDHFQRPPASRMTQQQLLLFEEENTRVAQHREQEVTKIVKSIYDLNDIFKDLGHMVQEQGTVLDRIDYNVEQTQTRVSEGLRQLHKAEMYQRKNRKMCVILVLAAVTFFMLLLLILTKL
Protein: Variant surface glycoprotein (VSG), putative (Q387N7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MINYLFAVALLIMQQLAAVDATAQKGMLPAFWKPLCGLSEELDSKPHKAISDLQSATSQVELMQRATLRAQIYGLAMAGTKEATPTALAELYYSSKVQASLSKLRTTSIQAAIETASAATYLKGHVDEYLSLWSNVNQGGSDGCLLTNAGSAAATITQNRLGGTECKLKLTGASSSGIQPTHITANGFPQLAHRISGDDEQHSSGKCTLASGHTNNGLGDGSALAANFKVLDGYLTIPNSANALSINSVQTMTQEHANTHPAWYNAWSKNKLPPQAEDPAFTNTTGEIKNYNLVSEAIRTVNLKKAEAADADVEAQVTSYFGGKDDAKWKEFIAKIEKFPIPAKTGKQAEPTTLGAIEDTETLLTILYHYQLQLSKRLTELQTRLDDTESKGKNKTPEQLCNEIKDAKTCNADKKCKYDETKKEEPKCTLSEEGKQKAAEKANQETEGKDEKPGTTNTTASNSFVINKAPLLLAFLLF
Protein: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.55) (Q97U28)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal).
Interaction partners:
- 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase
- D-gluconate/D-galactonate dehydratase
- NAD
- Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
- gluconate dehydratase
- Carbon monoxide dehydrogenase, medium chain.
- Carbon monoxide dehydrogenase, small chain. Amino-end
- Carbon monoxide dehydrogenase, large chain
- Uncharacterized aldolase SSO3226
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MGRQGNLEELWCLRMPEIITPIITPFTKDNRIDKEKLKIHAENLIRKGIDKLFVNGTTGLGPSLSPEEKLENLKAVYDVTNKIIFQVGGLNLDDAIRLAKLSKDFDIVGIASYAPYYYPRMSEKHLVKYFKTLCEVSPHPVYLYNYPTATGKDIDAKVAKEIGCFTGVKDTIENIIHTLDYKRLNPNMLVYSGSDMLIATVASTGLDGNVAAGSNYLPEVTVTIKKLAMERKIDEALKLQFLHDEVIEASRIFGSLSSNYVLTKYFQGYDLGYPRPPIFPLDDEEERQLIKKVEGIRAKLVELKILKE
Protein: SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (Q8NC51)
Organism: Homo sapiens (Human)
Function: May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:28695742}. Nucleus {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:28695742}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12505151}.
Interaction partners:
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL18
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS19
Sequence:
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA
Protein: Interleukin-17C (IL-17C) (Cytokine CX2) (Q9P0M4)
Organism: Homo sapiens (Human)
Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-17 receptor E
- Interleukin-17 receptor B
- Interleukin-17 receptor A
- Interleukin-17 receptor C
- Interleukin-17 receptor D
- Interleukin-22
- Interleukin-33
- Cannabinoid receptor 2
Sequence:
MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCTCVLPRSV
Protein: Insulin receptor substrate 2 (O70360)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
DPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRSSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSLPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQPRSAAALPPSGAAVPAPPSGAGRTFPVNGGGYKASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFFSAALRPGGEALKGVPGHCYSSLPRSYKAPCTCGGGDNDQYVLMSSP
Protein: Integrator complex subunit 7 (Int7) (Q8JGR7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. May play a role in DNA damage response (DDR) signaling during the S phase (By similarity). Essential during embryogenesis for eye development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NVH2}. Chromosome {ECO:0000250|UniProtKB:Q9NVH2}. Cytoplasm {ECO:0000250|UniProtKB:Q9NVH2}. Note=Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000250|UniProtKB:Q9NVH2}.
Interaction partners:
- Integrator complex subunit 5
- Integrator complex subunit 1
- Integrator complex subunit 3
- Integrator complex subunit 4
- Integrator complex subunit 2
- Integrator complex subunit 11
- Integrator complex subunit 8
- Integrator complex subunit 9
- Integrator complex subunit 10
- Integrator complex subunit 6
Sequence:
MSLSAARSFLSEAAYGEQELDANSALMELDKGLRSCKLGEQCEAVVLFPKLFQKYPFPILINSAFLKLADIFRLGNNFLRLCVLKVTQLSEKHLEKILNVDEFVKRVFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAIFAAASFSSHSKDFAAGICNKISEMIQGLDTPVELKLKLIPMLQHMHHDASLASCSRELLQELVSSYPSTSMLIVTLHTFTQLATSSLVDIPEQICLLLQYLKEDPRKAVKRLSIQDLKLLAKKAPHLWTRKNIQVLCECALHTPYNSLKLGMLSVLSTLSGTIAIKQYFSPNAGDSSPAPHHTDLVKLAQECCYHSDLAVAAHGITVLTSIAAFCPEKEVIQLEQETVMGMESLILLCSQDDSKTAQATLKTALTSLVQMLKTCPHLSQSSVELLLRQLHCACDPARVLMCQALAAIATQQPVLVEGMLGDLLELFRVASHRTSEKQQELLVSLATVLFVASQASLSAEVKAVIRQQLENVANGWTVYQIARQASRMGCHDFSRELYQSLRTRVASEHFYFWLNSLMEFSQAEQCLSGLEDGDYSAAMSAISEALKSYQKGIASLTAASTPLSPLTFQCEFVKLRIDTLQALSQLICTCNSLKTSPPPAIATTIALSSGSDLQRCGRISTQMKFSMDEFRSLAARYADLYQSSFDADYATLRNVELQQQSCLLVSYVIEALIIDPQTASFQEFGTHGSILAESEYELRMMAVFNHVLEEVENLSRKHPPVSYLHTGCLCDTVIAILKIPLSFQRYFFQKLQSTSIKLALSPSPRTPNEPIPVQNNQQLTLKVEGVIQHGSSPGLFRKIQAVCLKVSSTLQTKPGSDFKIPLESKTNEIEQKVEPHNDYFSTQFLLNFSILGTHQVSVEASVVDTSGIEWKTGPKNTVSVKSLEDPYSQQLRHQLQQQQQNVPQPAAQRNISTRFQ
Protein: Guanylate-binding protein 10 (Q29RG2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWIVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNKLGILVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEYSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGKKAIAEERAQKVAAEKEQDLLRQKQKEQQEYMEAQEKSHKENLEQLRRKLMQEREQLIKDHNMMLKKQLKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKDALLNGFSTVLFHYLVRYLKHL
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (D3VVH9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFENHNSEVDEGKF
Protein: Alkaline ceramidase (AlkCDase) (EC 3.5.1.23) (Alkaline N-acylsphingosine amidohydrolase) (Alkaline acylsphingosine deacylase) (Protein brainwashing) (Q9VIP7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Neutral ceramidase
- Ceramide kinase, isoform A
- sphingosine kinase
- LD18904p
- Putative neutral sphingomyelinase
- sphingosine kinase
- ceramide glucosyltransferase
- Sphingolipid delta
- FI04477p
- Non-lysosomal glucosylceramidase
Sequence:
MGGMGGGGLLDIYAMAWEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILWVFMAAFSLFYPKRYYPKFVKNDRKTFSWLMLLSAIAATGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVSDQRVYRLGIRSTTVWAVAVFCWINDRIFCEAWSSINFPYLHGFWHIFIFIAAYTVLVLFAYFYVESELPQRQPLLKYWPKNEFEFGIPFISIRNPGKALRNTI
Protein: B9 domain-containing protein 2 (Stumpy) (Q3UK10)
Organism: Mus musculus (Mouse)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:18287022}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:18287022}. Nucleus {ECO:0000269|PubMed:18287022}.
Interaction partners:
- B9 domain-containing protein 1
- Tectonic-1
- Tectonic-2
- Coiled-coil and C2 domain-containing protein 2A
- Transmembrane protein 231
- Meckelin
- Transmembrane protein 216
- Centrosomal protein of 290 kDa
- Jouberin
- Transmembrane protein 17
Sequence:
MAEVHVIGQIIGATGFSESSLFCKWGIHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHADTIYSGADRYRLHTAAGGTVHLGIGLLLRHFDRYGVEC