Protein: InaD-like protein (Inadl protein) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Q63ZW7)
Organism: Mus musculus (Mouse)
Function: Scaffolding protein that facilitates the localization of proteins to the cell membrane. Required for the correct formation of tight junctions and epithelial apico-basal polarity (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (By similarity).
Subcellular location: Cell junction, tight junction {ECO:0000250|UniProtKB:Q8NI35}. Apical cell membrane {ECO:0000250|UniProtKB:Q8NI35}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NI35}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14988405}. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (By similarity). Localizes to the most apical strand of TJP1/ZO1 condensates during junctional condensation elongation (By similarity). Localized in the paranodal region of myelinating Schwann cells (PubMed:12403818). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q8NI35, ECO:0000269|PubMed:12403818}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cytoplasm, perinuclear region. Note=Concentrates around the nucleus upon HTR2A coexpression.
Interaction partners:
- Protein PALS1
- Angiomotin
- Protein crumbs homolog 3
- Protein crumbs homolog 2
- Protein crumbs homolog 1
- Tight junction protein ZO-3
- Angiomotin-like protein 1
- Angiomotin-like protein 2
- Multiple PDZ domain protein
- Partitioning defective 3 homolog
Sequence:
MPENPAAEKMQVLQVLDRLRGKLQEKGDTTQNEKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRKGLLVFTDGSITNGNAQRPCSNVTASELLPWTQKSASEDFNSVIQQMAQGRHVEYIDIERPSTGGLGFSVVALRSQSLGLIDIFVKEVHPGSVADRDHRLKENDQILAINDTPLDQNISHQQAIALLQQATGSLRLVVAREVGHTQGRASTSSADTTLPETVCWGHTEEVELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPVGEIAVTPPTPVSLPVALPAVATRTLDSDRSPFETYSVELVKKDGQSLGIRIVGYVGTAHPGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASPFEHSSSRETVAEPPKVPERAGSPKPEANLSVEAEEIGERLDNLKNNTVQALEKPDVYPEKVPGSPENELKSRWENLLGPDYEVMVATLDAQIADDEELQKYSKLLPIHTLRLGMEVDSFDGHHYISSVAPGGPVDTLNLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTMEPALLEAEVDHSVDVNIEDDDDGELALWSPEVKTVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEDEKEERFSLHSNNNGDSSEPADAVHEIHSSLILEAPQGFRDEPYLEELVDEPFLDLGKSLQFQQKDVDSSSEAWEMHEFLSPPLDGRGEEREMLVDEEYELYQDHLRAMESNPPPPHIREAAPASPVLELQAGTQWLHANLSGGERLECHDAESMMSAYPQEMQQYSYSTADMMEETFGLDSRAPIPSSEGNGQHGRFDDMGHLHSLTSSSLDLGMMIPSDLQGPGVLVDLPAVAQRREQEDLPLYRLPSARVVTKPSSHMGLVSSRHANAACELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHAEAVEAIKSAGNPVVFVVQSLSSTPRVIPTVNNKGKTPAPNQDQNTQERKAKRHGTAPPPMKLPPPYRAPSADMEGSEEDCALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPTRVKLVFIRNEDAVSQMAVAPFPELSHSPSPVEDLGGTELVSSEEESSVDAKHLPEPESSKPEDLSQVVDDNMVAEQQKESESPDSAACQIKQQTYSTQVSSSSQDSPSSPAPLCQSAHADVTGSGNFQAPLPVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLDAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLVVYRDEAQYRDEENLEVFLVDLQKKTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLIRGDQILSVNGEDMRHASQETVATILKCVQGLVQLEIGRLRAGSWAASRKTSQNSQGDQHSAHSSCRPSFAPVITSLQNLVGTKRSSDPPQKCTEEEPRTVEIIRELSDALGISIAGGKGSPLGDIPIFIAMIQANGVAARTQKLKVGDRIVSINGQPLDGLSHTDAVNLLKNAFGRIILQVVADTNISAIATQLEIMSAGSQLGSPTADRHPEDTEEQMQRTAD