wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform (AtB' zeta) (PP2A, B' subunit, zeta isoform) (Q9LVE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signaling by dephosphorylating and inactivating BRI1 in the cytoplasm. Involved in growth regulation and stress signaling. Involved in the regulation of reactive oxygen species (ROS) signaling.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19672620, ECO:0000269|PubMed:26517938}. Mitochondrion {ECO:0000269|PubMed:19672620}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine protein phosphatase 2A regulatory subunit B''beta
- Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Serine/threonine-protein phosphatase 2A activator
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''epsilon
Sequence:
MIKQIFGKLPRKPSKSLQNDSNGEGGVNNSYYASNSSTTSISKPSSTSSKSSSASGSRVANGTLAPNSMSSNRNTNQGKKPLGGDAVVQAGPFPSSGGVYEALPSFRDVPISEKPNLFIGKLSMCCVVFDFSDPSKNLKEKEIKRQTLLELVDYVASVGFKFNDVSMQELTKMVAVNLFRTFPSANHESKILEIHDMDDEEPSLEPAWPHVQVVYEILLRFVASPMTDAKLAKRYIDHSFVLKLLDLFDSEDQREREYLKTILHRVYGKFMVHRPYIRKAINNIFYRFISETEKHNGIAELLEILGSIINGFALPLKEEHKLFLLRALIPLHKPKCSSVYHQQLSYCIVQFVEKDFKLADTVIRGLLKYWPVTNSSKEVMFLGELEEVLEATQAAEFQRCMVPLSRQIARCLNSSHFQVAERALFLWNNDHIRNLITQNHKVIMPIVFPALERNTRGHWNQAVQSLTINVRKVLCEIDQVLFDECLAKFQVEEVNKTEVKAKRERTWQRLEDLATSKTVVTNEAVLVPRFVSSVNLTTSSSESTGS
Protein: Electron transport regulator A (P46148)
Organism: Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Function: Regulates anaerobic growth on fumarate, nitrite, Fe(3+), TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+).
Interaction partners:
- Universal stress protein UspE
- Cbb3-type cytochrome oxidase assembly protein CcoS
- Cbb3-type cytochrome oxidase assembly protein disulfide bond oxidoreductase DsbD family
Sequence:
MTIEQNKNRRSAASGCAIHCHDCSMGTLCIPFTLNANELDQLDDIIERKKPIQKGEQIFKSGDPLKSLFAIRSGTIKSYTITEQGDEQITGFHLAGDVIGFDGIHAQSHQSFAQALETSMVCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILLLSKKNAEERLAAFISNLANRFGNRGFSAKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYIIIVDHHELNLLAGNARIAR
Protein: Ubiquitin-activating enzyme E1-like (Pmt3-activating enzyme subunit 2) (O42939)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity).
Interaction partners:
- SUMO-conjugating enzyme ubc9
- DNA damage tolerance protein rad31
- Ubiquitin-like protein pmt3/smt3
- Ubiquitin-like-specific protease 1
- Ubiquitin-like-specific protease 2
- NEDD8-conjugating enzyme ubc12
- DNA repair protein rad60
- E3 SUMO-protein ligase pli1
- UV excision repair protein rhp23
- Autophagy-related protein 8
Sequence:
MPTLMQLSNDMKPLTFVEALRNFKSAKVLLVGAGGIGCELLKNLLMSGVKEVHIIDLDTIDLSNLNRQFLFRKKHVKQPKAIVAAKTASSFNPNVKLEAYHANIKEDRFNVAWFRQFDLVFNALDNLDARRHVNKQCLLASVPLIESGTTGFLGQVQVIIHGKTECYDCNPKEPPKTYPVCTIRSTPSQPIHCVVWAKSYFFPQLFSNDQESDGIIDNVSANEMERREIAELARETTELNELRSSIGQSDNGFEKIFTKMFTKDIVRLREVPDAWTYRSPPKELSYSELLENAEKATSPWLNEQNVWNVAESFAVLRDSIRRLALRSKSSKDDLSFDKDDKDTLDFVAAAANLRAHVFGIQQLSEFDIKQMAGNIIPAIATTNAVIAGLCITQAIKVLQGDLNDLKNIYLAKRPTRVLHCEKTCKPNPYCPTCSFVLLQLGVNDKNMTLRVLVDDILKSRLHYSEEVSVLNDKLIYDPDFDDNLDKTFDDLGINPAKNTILTVLGDSAVEKDDDGEEATRVPLLIEVTFIDSNSTEGLPYQILSNATSIPLKQQPPSNSPEDSQVLTDEINEVNDFSSSERIVINLDEYDIIVDSKTSSHNKQLKRRPSNDTLTQEAKSKKQAKIHTM
Protein: Basement membrane proteoglycan (H9G354)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKRSSTVLAALLALLLVATNDAARHRKYRQTYQDIDSDDDDTSDVQITVFPSEKEVRDGRDVSFECRARTSDNSVYPTVRWARVGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNTVEARATLSVVSYGPQEVSNGLRQAGQCMADEKACGNNECVKNDYVCDGEPDCRDRSDEANCPAISRTCEPNEFKCNNNKCVQKMWLCDGDDDCGDNSDELNCNAKPSSSDCKPTEFQCHDRRQCVPSSFHCDGTNDCHDGSDEVGCVQPTVVDPPQTNLQVPRGTTFSLTCKAVAVPEPYINWRLNWGPVCEPPRCLQTSEGGYGTLTIHDAQPVDQGAYTCEAINVKGRVLATPDCIVRVVDDPRPQPPQPPTAPPQRASCDTRGAVTPYPNNYGTCECKSQVTGPNCDQCKPGAFHLSEKSPEGCLKCFCFGVSNDCRSSGHYRTKDRLMFAGDAEGVTISDIEERTIDRNTPFSFFKTGYLTFDGTTDGVAKYWRLPQRFLGDKVTAYGGKMEFEIEFSGSGHHSSEPMVVLKGNQNILVHRVRNQEHVLRSDSPVRITVETYETNYEQLNGAAATREDLLMVLADLDAFLIRATHVAHQTSTSLGDVSWEIAVDRYTPDGLALEVEQCVCPPGYLGTSCEDCAPGYERSGYGPYLGTCVPIQPRHQQCGPGAVAPTAPAQGQCQCKASVIGPNCDRCAPNSFGLAPTNPQGCIPCFCSGVTQQCSASSYRRTSVSIDYARGDRDQLELTTSDSRQPYSPQTRAELSGQAIEFRSFEEARGQTLYWKLPEKFLGDKVTSYGGTLEYTFKFSGNGNSDQSADVILRGNDIALQYKHREPFYADRENKVQIKIIETSWQRVDGQQATREHLLMTLADLDTLLIKSTYNDDCTDSQLLSANLEFAEPYGQGLTAAEVEQCICPPGYVGTSCEDCAPGYSRTGGGLYLGLCEKCECNGHASQCDKEYGYCLDCQHNTEGDQCERCKPGFVGDARRGTPNDCQPEATRAPCHCNNHSPRGCDSFGRCLLCEHNTEGTHCERCKKGYYGDATKGSPYDCTPCPCPGASDCYLDNEGQVACRICPAGLQGRLCNECAPGYTRSNKPAGRVCEPIGQVTNEDITFVQKPHEVLRVRIMEPKRQIALPGDRVHWICQVTGYTTEKIHVEWTKVGEMSLPPNAKAYDGYLVLKGVEAENAGQYRCTATTITQYATDDALLTISKRISGRPPQPVIDPPHLVVNEGEPAAFRCWVPGIPDCQITWHREQLGGPLPHGVYQTGNALKIPQSQLHHAGRYICSAANQYGTGQSPPAVLEVKKPVIPPKVDPIRQTVDRDQPARFKCWVPGNSNVQLRWSRPGGAPLPSGVQEQQGILHIPRASDQEVGQYVCTATDPSDNTPLQSEPVQLNIRDPAPPQRGAAPQIDPPNQTVNVNDPAQFRCWVPGQPRAQLKWSRKDGRPLPNGILERDGFLRIDKSQLHDAGEYECTSTEPDGSTQLSPPARLNVNQPQAIQPQVDPPVQTVNEGEPSRIRCWVPGHPNIQLQFVKRGRRPLPAHARFSQGNLEIPRTLKSDEDEYICIATDPTTNRPVESNPARVIVKSQGTPPRPVATPPLLSVAPGSPARFNCVAHSDTPARIRWGFREENGPLPEHVNQDGDDIVISEAGDRNVGEYVCSATNDFGTGVADPVRLEVTEDQEPPTAVVEPRTWNGKPGERHQFRCITTGSPTPKITWTGPNGSPLPHDVTPLEPNILDFSNGRSELNGDYTCTASNPIGEASDHGNVNIGPSLTVKTNPPGPKLIVTVGEPLQVKCEAFGAPGDPEPEVEWLHDPGPERGDLPDDFKPVTISEQFIRHPNVGLGNAGVYTCKGSSAHATATKNIYIEVVEPSRIATVSILGGSSQWFDQGEKGELICTATGSSLVDRLEWEKVDDQLPTDVEEHNEPGLLHFPSFKNSYAGEYRCNGYRNNEIIASAAVHVHSSANADDEPKVEIEPPRVRVVSQGDNIVLKCSVQGAENGEHFKWALLRGGSLVRQLGTEPTLEITKADPSNDFGVYRCNVEDNNGLVIGSAFTAVSVGQQDKSHAQIVKFDDKSDASFTCPIYSVPGSKVDWTYENGDLPSKAVPNGNKIEIKEFDDASAGTYVCKVSFDGNVVEGFVTAQMFVPDTIIQVLLEVSSESPQIGDRAWFDCKVTGDPSAVISWTKEGNDDLPPNAQVTGGRLLFTDLKEDNAGVYRCVAKTKAGPLQTRTVLNVGSGKRKRKHLGNRRGRRLRHRRRNAQNGPLSRKTRTTTKLFGSWF
Protein: Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) (Q9WVE8)
Organism: Mus musculus (Mouse)
Function: Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000250|UniProtKB:Q9UNF0}. Membrane, caveola {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21807942, ECO:0000269|PubMed:26092940}. Cell junction, adherens junction {ECO:0000269|PubMed:33972531}. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Interaction partners:
- Protein kinase C and casein kinase II substrate protein 3
- EH domain-containing protein 1
- Actin nucleation-promoting factor WASL
- Protein kinase C and casein kinase substrate in neurons protein 1
- EH domain-containing protein 2
- EH domain-containing protein 3
- Dynamin-2
- Caveolae-associated protein 1
- Caveolin-1
- F-BAR domain only protein 1
Sequence:
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWIAVMSEAERVSELHLEVKASLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHTACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKSLKELDQTTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKTIYRELEQSIKAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKAVDGVTLTGINQTGDQSGQNKPGSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSISEKEDIKAKNVSSYEKTQTYPTDWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFKAGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ
Protein: MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) (Q14149)
Organism: Homo sapiens (Human)
Function: Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504}. Nucleus matrix {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:20501696}. Nucleus, PML body {ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:27440897}. Chromosome {ECO:0000250|UniProtKB:F7BJB9}. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. {ECO:0000269|PubMed:20501696}.
Interaction partners:
- E3 ubiquitin-protein ligase TRIM33
- Histone H3.3
- Histone H3.1
- Histone H3.3C
- Histone H3.2
- Histone H3.1t
- Histone H3-7
- Interferon-induced helicase C domain-containing protein 1
- SUMO-activating enzyme subunit 1
- Exosome complex component 10
Sequence:
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST
Protein: Uncharacterized protein (Q38EP6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTPTVTPLQLPKREGVKPFPDAPLGGAAVEPHALPPKPRTRASSVNDGRKKTTSYPSYMNPLKLPTKAIVWTNKPPVKPNKISVSLENFEDAPRIKGVFNSPRSLKACEIAVVDPRNLLKRPLSHFEGKGVPETLAQMRHTYYENRRKTKLEEVRRIRDGLPVEVPQEKEDEQTNVNGRTPSVNNGHRAPLLRERSPPPMVRQRTPMRRSTSFGFCSRSSSSAPYKVGGEKPYPPSRRTTLHGADGRSPSVGALKVLNRAMSENRSLSAADYDMLRRIEEREERANEARQRAEEMEAARERELLERGLRKELHGINKLIERENERISAVQMRRQKLEMRLQQARERQKRSEEERLGQWNAKR
Protein: Serine/threonine-protein kinase SRK2B (EC 2.7.11.1) (OST1-kinase-like 6) (SNF1-related kinase 2.10) (SnRK2.10) (Q9C958)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable protein phosphatase 2C 24
- Protein phosphatase 2C 37
- Protein phosphatase 2C 16
- Protein phosphatase 2C 56
- Probable protein phosphatase 2C 75
- Protein phosphatase 2C 3
- Probable protein phosphatase 2C 78
- Protein phosphatase 2C 77
- Protein phosphatase 2C 7
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
Sequence:
MDKYELVKDIGAGNFGVARLMRVKNSKELVAMKYIERGPKIDENVAREIINHRSLRHPNIIRFKEVVLTPTHIAIAMEYAAGGELFERICSAGRFSEDEARYFFQQLISGVSYCHAMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSMPKSTVGTPAYIAPEVLSRGEYDGKMADVWSCGVTLYVMLVGAYPFEDQEDPKNFKKTIQRIMAVKYKIPDYVHISQDCKHLLSRIFVTNSNKRITIGDIKKHPWFLKNLPRELTEIAQAAYFRKENPTFSLQSVEEIMKIVEEAKTPARVSRSIGAFGWGGGEDAEGKEEDAEEEVEEVEEEEDEEDEYDKTVKQVHASMGEVRVS
Protein: DNA repair protein RAD52 homolog (P43351)
Organism: Homo sapiens (Human)
Function: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication protein A 32 kDa subunit
- DNA repair protein RAD51 homolog 1
- Replication protein A 70 kDa DNA-binding subunit
- Replication protein A 14 kDa subunit
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Transcriptional regulator ATRX
- Breast cancer type 2 susceptibility protein
- Fanconi anemia group M protein
- Breast cancer type 1 susceptibility protein
- E3 ubiquitin-protein ligase RAD18
Sequence:
MSGTEEAILGGRDSHPAAGGGSVLCFGQCQYTAEEYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPRQLPLEVDLTKAKRQDLEPSVEEARYNSCRPNMALGHPQLQQVTSPSRPSHAVIPADQDCSSRSLSSSAVESEATHQRKLRQKQLQQQFRERMEKQQVRVSTPSAEKSEAAPPAPPVTHSTPVTVSEPLLEKDFLAGVTQELIKTLEDNSEKWAVTPDAGDGVVKPSSRADPAQTSDTLALNNQMVTQNRTPHSVCHQKPQAKSGSWDLQTYSADQRTTGNWESHRKSQDMKKRKYDPS
Protein: Trafficking protein particle complex subunit 9 (A0A8I6AB20)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MLLGLKRHYKKRCQGRMRKHVGDLCLQAGMLQDALVHYHMSVELLRSVNDFLWLGAALEGLCSASVIYHYPGGTGGKTGARRLPGNSLPSEAANRHRPGAQEVLIDPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYKNAGVIELEACVKAVRVLAIQKRGMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRACYKLLLETLPGYSLSLDPKDFNKGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVTQSLENYTAKCPGTMEPITLPDGLTLPPVPFTKLPIVRCVKLLSLPTSLRPQKVKSLLGQSMSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCEVQLMVYNPMPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGMITVNGYHTTVFGVFSDCLLDNLPGLKTSGSTVEVIPALPRLQISTSLPRSAHSLQPSAGDEIATNVSVQLFNGETQQLAITLENIGLEPLEQLEVTSKLLTTKEKLYGDFLSWKLEETLAQFPLQPGKVATFTINIKAKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVESRPTNPSEGSKTGDLGHVKTLEAILNFKYSGGPGHVEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVCARNNSELVLHASECQRMAIQVDKFNFESVPESPGEKGHFANLKQLEEERQEARGLEISSKLDIRWRIPSLKRSGEASVEGLLNQLILEHLQLAPLQWDVLVDGQPCDCEVAAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDVISFVGSSTFYLDTVQPSGQSACLGALLFLYTGDFFLNIRFHEDCKSKELPPSWFCLPSVHVRALEAQA
Protein: Dipeptidyl peptidase 10, isoform B (EC 3.4.14.1, EC 3.4.14.2, EC 3.4.14.4, EC 3.4.14.5) (X2J9P4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MPEQDNYDDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGWVDTVAVPLFAANASIYVAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVKRHLYRSMTAFFEDCFKKLIDQQQQNQTDSMDFLDFHSFYGR
Protein: Protein dyf-7 (Abnormal dye filling protein 7) (Q09276)
Organism: Caenorhabditis elegans
Function: Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19344940}; Single-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:19344940}. Secreted {ECO:0000269|PubMed:19344940}. Note=Located at dendritic tips. Secreted following proteolytic cleavage in vitro. {ECO:0000269|PubMed:19344940}.
Interaction partners:
- Dendrite extension defective protein 1
- Ligand-Gated ion Channel
- Ig-like domain-containing protein
- ZP domain-containing protein
- ZP domain-containing protein
- Ig-like and fibronectin type-III domain-containing protein 2
- Cuticlin-5
- Uncharacterized protein
- Moesin/ezrin/radixin homolog 1
- Intraflagellar transport protein osm-1
Sequence:
MNQLWRASCLQVLITFLLIHQNKASEKDRFVELVDCIADSFTVVLNKSDPEVMRMISNPKSQPVVYVYGHKTRHPCGTSMKDEKGLTNFNLTIPYGSECDVTLTDLPKHRYAETTVVLEDNADLSFGKTTRLNHVFCLYTRNVKTIRFSDVSNGHEVIASTGGKPKPKVEMLFRSTDSGKTLQAARENEFVEFFIALSPDSAYHGISPKECTFSDREDISAPDAKKITFVQGGCPVNGMNDIIDPLANVNDQIYFSKFRTFRFGNQSTVFVHCQVQVCLKKDECSKTCYKKVSDSNLTAERLRFRHKRSITDLERRTTRSAPTDDNGSLDLTNSLTVVSRIESAELVASPISQPTIVDTPSEQRRDPCPKSSNMGFIPLIIMGSLASLLLFSAGAAIYFGCKLKSMKKKDSFDMMSAFSNPTVSMPVTYSHYQRSAYNASVDSLYR
Protein: RAB5C, member RAS oncogene family (Rab5c protein) (Ras-related protein Rab-5C (EC 3.6.5.2)) (Q7ZVP2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Early endosome antigen 1
- RAB guanine nucleotide exchange factor
- RAB guanine nucleotide exchange factor
- Rabaptin, RAB GTPase-binding effector protein 1.
- HESX homeobox 1.
- Rab GDP dissociation inhibitor
- GTPase-activating protein and VPS9 domains 1.
- Rab GDP dissociation inhibitor
- Rabenosyn, RAB effector.
Sequence:
MAGRGGPARTNGAAPVGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTLCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFTRAKNWVKELQRQASPNIVIALAGNKADLANKRAVDFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKSEPQGGAGSGGRARGGVDLQETAPQGRSGQCCGGGN
Protein: Strawberry notch homologue 1 (D6RUV3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDPGQDLLLAALSESGICPNDLFDVDVQDSVPLVSSQQPVSLNALDIGLSNEASGVVRIDPPVPPTPTVTIREKPQPSTTTFVLNQLNQLPSLGTIVVSKPSTGSSTRQTITVTKVLHSSSPAQRSSASPSVCTAAPANTEQIRLKDLLRSSSLKSSSLGELMKLKPPADIAPPVATATGTTEVNNGLKKEVSSKDVARIWINDDMKMRSFSPVNKLPGMKEEEEPEEEEEEELGHAETYAEYMPMKQRIGLRHPDPVVETSSLSSVNPPDVWYRLSIPEETIDRGWLSALQLEAVTYAAQQHETFLPNGDRAAYLIGDGAGVGKGRTIAGIIYENYLLGRKRSLWFSVSNDLKYDAERDLRDIGAKNIQVHSLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQSGGKYKTRFKQLLHWCGDDFDGVIVFDECHKAKNVCPIGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREFANFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVPLTLDYIKMYNKAVRLWVSAREKFQQAAQLMDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVRRVVQLAREDVKNGKCVVIGLQSTGEARTLEALEEGGGELNDFVSTAKGVLQSLVEKHFPAPDRQKLLSLLGIDLSAKKTPSPAENKTEQKGKKRKVPESKKHVKKARKSGGLSGSSSDDSSSEDSDRDAESDDSFKSISSGDEDDFNPFKDDSSEDEEDDPWLIRKDSKKSKDKRNKKKKKSIDPDSIQSALLASGLGTTRPTFTAPIKPANPTLAVAKSDPEESSCVTSQDAVEDAQRMKRDLLEKLELLAEDLPPNTLDQLIDELGGPDNVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNLTEKQTFMDGDKNIAIISEAASSGISLQADRRVKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAQRLESLGALTHGDRRATETRDLSRFNFDNKYGRNALEIVMKSIVSLDSPLVSPPADFDGDFFKEIRNGLIGVGLINVEDRSGVLSLDKDYNNIGKFLNRILGMEVQQQNALFQYFSDTLSAVIQNAKKSGRYDMGILDLGSGDEKVKKVDVKKFLTPGYSTSGHVELYTVSVERGMSWEEATHVWADQNGPDDGFYVQVRNNKKIAILVKEVNPRKRLFMVYRPNIGKQAKLETYTDIKKRSKKVLSDDAKQHWMDQYSCSADVCSHAYWRGNCKKASVGLQCEIGLRCRTYFVLCGSVLSVWTKVEGVLASVSGANVKMQIVRLRTEDGQRIVGLIIPQNCVSPLVNILSSSDQSQQLAVQQQHLWQQLHPQSLTHTPLT
Protein: Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (Q8C0T5)
Organism: Mus musculus (Mouse)
Function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.
Interaction partners:
- Ras-related protein Rap-1b
- Ras-related protein Rap-1A
- Disks large homolog 4
Sequence:
MTSLKRSQTERPVTADRASVVSTDGAPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGDSFFDLLKGYKDDRSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVKRYTVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISSEFIVLIEQETKSVAFNCSCRDVIGWTSSDTSLKIFYERGECVSVESFISGEDIKEIVRRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYQMNEGISYEFKFPFRNNNKWQRNASKGAHSPQVPSQLQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDISGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGPSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKAESSLSLDIHSKSQGGSSPLSRENSTFSINDAASHTSTMSSRHSASPVVFSSARSSPKEELHPTASSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLQASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHALSSPQSPFPTTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDAASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSKDPSPTLASKVDQLEGMLKMLREDLKKEKEDKAQLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
Protein: Actin-depolymerizing factor 9 (ADF-9) (AtADF9) (O49606)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Does not display typical F-actin depolymerizing activity. Exhibits a high ability to stabilize and cross-link actin filaments. Functions as an actin bundling protein with the highest efficiency under acidic conditions. May play a role in the modulation of levels of histone H3 lysine 4 trimethylation and H3 lysine 9 and 14 acetylation at the FLC locus.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21570971}.
Interaction partners:
- Profilin-5
- Profilin-2
- Profilin-4
- Profilin-1
- Profilin-3
- Cyclase-associated protein 1
- Villin-5
- Villin-1
- Protein phosphatase EYA
- Fimbrin-5
Sequence:
MALKTATSGMWMTDDCKKSFMEMKWKKVHRYVVYKLEEKSRKVTVDKVGAAGESYDDLAASLPEDDCRYAVFDFDYVTVDNCRMSKIFFITWSPEASRIREKMMYATSKSGLRRVLDGVHYELQATDPTEMGFDKIQDRAK