Protein: Protein split ends (Q8SX83)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:10704397}.
Interaction partners:
Sequence:
MFRCRNMVRDNSRNICFGKLAETTTTQQQQQQQQFVVDSSTIINNNNNNNNNNNNQKLKRSTEEPPTNSFERNYYDRTTSRLVTQYQANNSTSLANSNSSPSSVSASASVFATAAGGSSERSRNRDRPYRNGSASVQGGGINSSNTTTTTAACTAGGSGSGAIGTGTGGLVGSGPGGVPQALGDRSSTQNIHQNHQSARVAPPQSWYEAATAATTAQLKSSGGSGNAGASAAVGFTMSSSPINHHPHQHPHLQNPQHPHYTSSPVVGAGSCPSAAQGQPQIQSQSQTTAVHRSVAYAGSAADDLLNTATSRNMLLHSSKLNKLLKGAGATGSGGERSGSESPGRAGGATPLTTTSTITNNSFSSNSLNNTITTATPTMPTIASGAAGSVGLGSGAEAGVCSNSGTASGDILNVAAVLAAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSSSHSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSSSSSSSSGSSCLTANPVVHSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALEVSHDKHFFGCKIEVEPYQGYDVEDNEFRPYEAELDEYHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKKQGLNAYAFCQYSDIVSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAAVKDMRGTILRRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAMPAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGGAGNSTQFEDVRCDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITGGAEGFTGSGGSILSRRRCGKTPKDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDYHHHHHHSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPSIKFPGHLPSAPQSLMLSCRRPSIDVGALSALSSSSAFRHGIVGASSMDQQHMMNASAAAKRRRVTTTMQQPSSSSTTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQLHSHHSHEASGGESADGSRPGTPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGVLFFQQQQSRSSGGGGAGNSYLQQQLGGGSTGGLGCIGAASSSACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSSHHQNQQNNHQQQSQQLHGSSSSNTCLMASPARPRSLSSNSSDSDVPGQNAGGSPSLDERLRNFEENYERWSGGSSREHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSASGNSNSSSGTVSSSASNSRHKFLDIDELQPSDIVKSVLAKKSVFDDDFQRLNKNQWYDPSSSDFALGSSSNIVTGSSLVANVSRHPGGPCSGNTSPALPNLAATKATPIIGNCSGGLGNSTGSKSAGLLQRLSSLSPMNSPQASMSPYNSPSPSPSVGGVTACLGQLTKPAAPGTASAGLSGGTAASSSSPAANSGPTKGLQYPFPSHPPLPNTAAPPPAVQPAPPPLPEMGKQSRLTGQSSGNNLTKSLSVPDGPQSSPARVQLQKSASVPGSTNVGAPSSLSLDSTTASVETSASISSSTSNGNSSLTSAAIHVQKPQQSTFVEEEHTKKSGTSTSQSSSSSSKKISSTHDKLHSKHNNRSESDKKIKKSDKNASSSDKRKNSSTSQSSKSATPRIEDDSSEADDTADKAEKNQRHEKEKKERQEKREKDLRKQVEREEKDRKAQQEEREKEDRKAKEEEKEREREKKAQEDREKKEREERELREKEQRDKEQKEKEIREKDLREKEQRERDNREKELRDKDLREKEMREKEQREKELHREKDQREREHREKEQSRRAMDVEQEGRGGRMRELSSYQKSKMDIAGEASSLTAIDCQHNKENAMDTIAQGTPGASPSTPSDNTPKERSRKLSRNSPVRLHKRRLSSQESNHSAGGGGSCGGSSHQIHHEDYVKRIRMENSQNISVHSSNQRLNDRRDSKEHKSSSFKEDKNSSSHISRPHGCGGSSASSSKHHHRRDKHHQKGSASSIETNSSIEVVVDPISQTKHNLNTSEEELQSHQPKREKEREHFSSHANSSSSRHKSKRDHHHHREKKRHSVAESTNTDEEHTPQQHNPHRRISAAGSGSAGELSSAATNTSSGKLHHQHHRRSVERKSSRGSDEGHHSSSKSLRAKLMMLSSADSDDTDDASKKHSIFDIPDDCPNVSMYDKVKARSCKNMQRQAEEKKIKAKFSQLKQSRAKKKRSTSYDGDSDTEFEDRQHRNSGSSSFHGRYPGLSSSDDDDDEETHQRRISSDSDAEHGGQDNQGASTLADANRVRQMQQNLRRLCDGDDSSEDEIRRNVMKHSHFGKRNSNSTRIASDSESQSQPAPDLTIKQEHPIAPAQEIKREQLSDEEQKFKSRHDSNSSIEERKLKTEREIKTELGDFYNSSEYTYTGKLKEYSPETRKKHKKSKRRLKSSSTADTSAAQTPLVMTPLTPSIFDVHSSSECKTKFDNFDDLKTECSSIPLEISAGERRKHKERKEKKREKLRNMTEATVPNSPTTNDTSSEKLSKEERHRLKKSKKSKSMDNSCNTKIYNSSGAHPSTSPSLPATPTSAPSTAQTSKRGEDKMEFIFGIISDEEESQFPEQAETNKDIIPSSVSTTGPIVSAALQTYKQEPSTPNSKNEEAHIQLTVHEPEQQQQLERSRLSGGSSSSSHADRERHRREKREKKRREKSQREQQNQIHQKSSKVETKVDDDNSVDMDEAGRALEAQLMSDFDTKPISEEATPSTAATYRSDMTDVFRFSDNEDNNSVDMTKQGVKSEQQEQHKSKDKKKKKKRSKEEKQEKLLQQQRRESLPNVASTSSAPPTPGKLTVNVQAASKHADLQLDAKHISSPPVCKPSPSLPCLIGDDDDDALHTPKAKPTTPSSRGNDGLTPSREKPRLISPIPKTPTIANSSTLSTQSAETPVSSGTVISSSALATTPTSSTAAGVSAAPGLDNSPTSASAQCKKKESFIPGFDGQLDDRISESAVQSISAEFNSTSLLDNIADEPKIPVASPPRATKPLDKLEESKSRVTISQEETESAVSALLGESFGTSSTTDYSLDGMDEMSSVNELETPTLVIAEPDEEAALAAKAIETAGEPASILEEPEMEPEREAEPDPDPEAEIESEPVVEVLDPEELNKAVQSLKHEDMMDIKADTPQSERDLQIDTDTEENPDEADSSGPSLKIDETVQSSSSPEKSISNNSPTPRETANIDIPNVESQPKLSNESTPQPSVITKLPFLDTPKTVPAGLPPSPVKIEPPTISKLQQPLVQPVQTVLPAPHSTGSGISANSVINLDLSNVISSCSNTSAASATASASASISFGSPTASQNAMPQASTPKQGPITPQQAIRTQSLIMQPPTISIPEQTPHFAVPQMVLSPQSHHPQQPGTYMVGIRAPSPHSPLHSPGRGVAQSRLVGQLSPVGRPMVSQPSPQQQVQQTQQQHALITSPQSSNISPLASPTTRVLSSSNSPTTSKVNSYQPRNQQVPQQPSPKSVAEVQTTPQLMTIPLQKMTPIQVPHHPTIISKVVTVQPQQATQSQVASSPPLGSLPPHKNVHLNAHQNQQQPQVIAKMTAHQHQQHMQQFMHQQMIQRQQHMQQQQLHGQSQQITSAPQHQMHQQHQAQQQQQHHNQQHLNQQLHAQQHPTQKQHQAQQQFNQQIQQHQSQQQHQVQQQNQAQQQHLSQQQHQSQQQLNQQHQAQQQQLQQIQKLQQMHGPQQQQKSPQGVGHLGGSTSIFASQQHNSQLPARGVPQQQHPQQLSHSSPCKPNTLVSVNQGVQPPAILTRVGSHSQPNQQQQLPHQQSSSGHPHQKQLSSPGANLPLQTPLNVIQNTPKIIVQQHIVAQNQVPPPQTQGNAIHYPQNQGKDSTPPGHVEPTPAMSAQKTSESVSVIRTPTPTTGLAVISANTVGSLLTEENLIKISQPKQDELIEQDSKEVDSDYWSAKEVNIDSVIKKLDTPLASKDAKRAVEMQAIAPAPIPNPQPGNQSMAQETALPTTSMSVNNSNDHDTEDETETRQLPPAKPPIPTVGRPPGRGGSAKRGRQPRGAKKVGGFPLNSVTAAPPGVDSLVVQPGDNGVQTRLRKPVTAPVTRGRKGRPPRNLLLQQQQLQQQQLDIQRKGMEMVTSATSSTPLPTPIPTSSVLTAAEKKARNQALTQAQEQNQVASQVGTGQDIYEFHEDGGEEPKPKTISSVAPSAEDQRPRLILTINKTQPSIKNISEMEQTIQQQQQQQSEVISNTDPIGGDNSESCNTRKSRRLQEKEDRSTVDDIIEDVVRNTNTPTGTGPHLPKGAQTPPRRSGRNAQAKKTDAVQIINAVGRPRRSKDRKTIGEQTANLIEEVTASNATVAASHLAPPEGAGVESHVPQLDAKEVEPVSVVTPISTPAPVSVAAPVTVPVPAMVPVKPTMPQHPKKKAIAAAEIESYQAINSSIPSGGLPMHQTAAPATQKITGGVADAVSKALVDPVTGVITAGMPQGKEGNLPAATAAAPANSSNEDGQAAPPPQLQHQQQQQHPQQPPQQQANLQINTTLIPSGLPNPITALGKSVQLETSAAALLNKPVSVLVKGNASQVIQQQQPQIVAPAKQPIILQQNPLPTVLHHAQHTTVRPPQPLKAHVLNREKNIQQQLTPTKQAVAQPPQHAPHSGHMLLTDTAGNQQLVQPQIIARHLQQQQHLQVNVPPPTAHSPHSPRIPSQQQQLGPGASISPQQQQPQTVVIKQAASAAQPQILHVVSSKASVVPQPQQQQLPPTSSTGPHLQLAKPNYSYAPTVLTPTLPAVQQQQQQHLYKQNNQQKGAQIQMPPHGIIMPTHPGMLLQQKLPAHLQPQQHQLNPSPPPGKPNPVLHGLQSGQIMPGSVGSPPPVSAAVLKTAQQQVNSVVPVAGIRTAIPNISPQSQPRVSPLVLPPGISGVPPFDASLHDLGAYVSGRRTQSPPPAHQQASPITPNDSTYRGVTASRDFMLYQHHLMRGGDYDDKMGSSPPLELRRPGSGPPRTIAVPHSLQSPQDRTAADSPQMAQVYVHNTRIPPAHFSEIASRGLYDSGALQLEPPPAHRPTATISVVVPQQMPAVSSGSPFIGRDGSVQPGSHHHPGKAMDMQLDEMDRMSMIAAVVQQQQEHLPPALPAGMELASQQAPPAMAPPPGDSLVTLLQRYPVMWQGLLALKTDQAAVQMHFVHGNPNVARASLPSLVETNTPLLRIAQRMRLEQTQLEGVAKKMQVDKEHCMLLALPCGRDHADVLQHSRNLQTGFITYLQQKMAAGIVNIPIPGSEQAAYVVHIFPSCDFANENLERAAPDLKNRVAELAHLLIVIATV