wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) (Q8R4D1)
Organism: Mus musculus (Mouse)
Function: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). Plays a crucial role in germ cells in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap. Can also be active at the cell surface of specialized cells. In the small intestine, plays a major physiological role in transepithelial absorption of Na(+). Regulates intracellular pH homeostasis of intestinal epithelial cells (By similarity). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins. Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:23220221}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28476888}. Note=Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (By similarity). Localized at the apical membrane in the gastrointestinal tract (By similarity). Recruitment to the plasma membrane upon acid stimulation (By similarity). {ECO:0000250|UniProtKB:Q4L208, ECO:0000250|UniProtKB:Q9Y2E8}.
Interaction partners:
Sequence:
MAEEEFSNTTHETFNFTLHTTLGVTTKLVLPTPAKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKVIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKHMSDVSGWQTFSQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLVDIEDARARRRSKKDVNLSKTEKMGNAIESEHLSELTEEEYEAHYIRQQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGRIQMKSLTNKWYEEVRQGPSGSEDDEQELF
Protein: Protein TIFY 11B (Jasmonate ZIM domain-containing protein 6) (Q9C9E3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Repressor of jasmonate responses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:17637677, ECO:0000269|PubMed:24204266}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:24204266}. Cell membrane {ECO:0000269|PubMed:24204266}. Note=(Microbial infection) Interacts with Pseudomonas syringae HopZ1a at the plasma membrane and in the nucleus. {ECO:0000269|PubMed:24204266}.
Interaction partners:
- Transcription factor MYC2
- Coronatine-insensitive protein 1
- Transcription factor MYC3
- Protein TIFY 5A
- Protein TIFY 5B
- Protein TIFY 7
- Transcription factor MYC4
- Protein TIFY 6B
- AFP homolog 2
- Protein TIFY 6A
Sequence:
MSTGQAPEKSNFSQRCSLLSRYLKEKGSFGNINMGLARKSDLELAGKFDLKGQQNVIKKVETSETRPFKLIQKFSIGEASTSTEDKAIYIDLSEPAKVAPESGNSQLTIFFGGKVMVFNEFPEDKAKEIMEVAKEANHVAVDSKNSQSHMNLDKSNVVIPDLNEPTSSGNNEDQETGQQHQVVERIARRASLHRFFAKRKDRAVARAPYQVNQHGSHLPPKPEMVAPSIKSGQSSQHIATPPKPKAHNHMPMEVDKKEGQSSKNLELKL
Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (P49884)
Organism: Bos taurus (Bovine)
Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. {ECO:0000250}.
Interaction partners:
- Tyrosine-protein kinase
- Nuclear receptor coactivator
- Nuclear receptor coactivator
- Nuclear receptor coactivator
- Transcription factor Jun
- Sp1 transcription factor
- Breast cancer type 1 susceptibility protein homolog
- Estrogen receptor beta
- Nuclear receptor corepressor 1
- Forkhead box A1
Sequence:
MTMTLHTKASGMALLHQIQANELEPLNRPQLKIPLERPLGEVYMDSSKPAVYNYPEGAAYDFNAAAPASAPVYGQSGLPYGPGSEAAAFGANGLGAFPPLNSVSPSPLVLLHPPPQPLSPFLHPHGQQVPYYLENESSGYAVREAGPPAYYRPNSDNRRQGGRERLASTSDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAVPSGDMRAANLWPSPIMIKHTKKNSPVLSLTADQMISALLEAEPPIIYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLALHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLRSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHFRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPANFGSAPPEDVNQSQLAPTGCTSSHSLQTYYITGEAENFPSTV
Protein: cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) (Q01062)
Organism: Rattus norvegicus (Rat)
Function: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity).
Subcellular location: [Isoform PDE2A3]: Cell membrane {ECO:0000250|UniProtKB:O00408}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform PDE2A1]: Cytoplasm {ECO:0000250|UniProtKB:O00408}.; SUBCELLULAR LOCATION: [Isoform PDE2A2]: Mitochondrion matrix {ECO:0000269|PubMed:21724846}. Mitochondrion inner membrane {ECO:0000269|PubMed:28463107}. Mitochondrion outer membrane {ECO:0000269|PubMed:28463107}.
Interaction partners:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Adenosine kinase
- Adenine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Guanylate kinase
- Deoxycytidine kinase
- Adenylosuccinate lyase
- GMP synthase
Sequence:
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAGLRQAAKDALSAVLPKVETVYTYLVDGESRLVCEDPPHELPQEGKIREAVISRKRLSCDGLGPSDLLGKPLARLVAPLAPDTQVLVIPLLDKETGTVAAVILVHCGQLSDSEEQSLQVVEKHALVALQRVQALQQRRPEAVQNTSADPSEDQKDEKGYTAHDRKILQLCGELYDLDATSLQLKVLRYLQQETQATHCCLLLVSEDNLQLSCKVIGEKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLTSDDVQQLQNMLGCELRAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDERAIQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDVTRAPVNGCCSLEG
Protein: RNA polymerase II-associated protein 3 (Q585V5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RuvB-like helicase
- RuvB-like helicase
- Telomerase-associated protein, putative
- PIH1 N-terminal domain-containing protein
- PIH1 domain-containing protein 1
- PIH1 N-terminal domain-containing protein
- High mobility group protein, putative
Sequence:
MDYAAAIKQQAEDLQDELKDLALWQEEVARQHEVNKMKKSATFVTNSVPPIRGTVPSLKEAVLKSAGVVEKEDPVKKQKDKGNELFQSGKLQEAVEAYAVGIDLDPEGPMAHVLYGNRALCYLKLERWSDAERDASSCVRLNRTYAKGYFRRATARKQLGNLKGARTDLEAVLALSPNDVSATNEMSLVTKMIRADRDGAEPVTRKKIVITEVDDDDDEQCVGEGAQDKTASPSVIESNTGRHPNTVGDQVVKNEIAELERFRAAQRDAQEARSRERETKLQYKGRTSSRVEIVEEINNESKEGVVVSSSPLSLNNGVTSASAQECPSRELAAVSTSGAAQRPATFKDKKMNEPVVPRMLKPTVKWTKDTLKAPKSFTEFERVFLDLKDDEELLCFYVSVIPPGSMQVLFGSNMTPDILLGMLKAAGRLSGTSTVSFLKGLCTVKRVRDISLFFDDCEKKVVEEVMDVVVSCGASDEDVSLFRRQLGVI
Protein: Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) (Q9Z118)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity).
Interaction partners:
Sequence:
MNNSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATSNEGTLLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAIAFPQAAGLSVSAVPGALGPLTLTSSAVSGRMAIPGASGIPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQIAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI
Protein: Protein adg1 (Q9P7E7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum.
Interaction partners:
- Probable secreted beta-glucosidase adg3
- Serine/threonine-rich protein adg2
- Glucan endo-1,3-alpha-glucosidase agn1
- Primary septum glucan endo-1,3-beta-D-glucosidase
- Chitin synthase regulatory factor 1
- Septin ring organizing protein mid2
- Metallothionein expression activator
- Uncharacterized protein C306.11
- Uncharacterized protein C6G9.15c
- Glucan 1,3-beta-glucosidase 1
Sequence:
MFLRSIFQTLCAVSFLAGSVFADSGVSIVSTPATTTVYLVRTVDCSSSEVTSQPVVTVYNVLKPDTVTFTVTETAGSYAKRSIEIDSDSVSPTSATTTTPVASATDVSVYSASIHVPTGNPPVDTHNPLSYDTEVTATTTFSIALPKFNKGDRVSSANTYSVSFVA
Protein: NEK6-subfamily protein kinase (EC 2.7.11.34) (Q5TBH1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHEN
Protein: Intraflagellar transport particle protein 140 (Q68K27)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MQPGAVGTQYLCCWLQGRPLDPNNEANIKNVRGTECAKIAWHPLLPLLAIGWKDGELGAISFWNAEERKLEEDSKIHRNTISSMTWTASGDRLITGDENGRISMWKTDRLMRPIHVVAYDEPGAVIRHTVVGLPEEMPDTNSQVVVAFYVADAQERAVVKWCNDQGYSGVVVGMSEGVHTLVHYPERDQLLVVGSSCTLNVLTRDEQLGTWVTASKMKFATGTGEAATGLQVAWAGNHTLASASEKDNVVRMYNFDTEDNYVLNLEQDSGLVSRVVCLAYDDRYNLLAVGTTDGRVMMYKFNQPNLNLEPVLDFAKCWEMQPAFFVGNRALAMEWGPFPRLMVVACNDAINVCRKTMLSYKFRDGVAIMQVAVDRVVLENLEVEPQRPPGRLQLQDMQLLGLDLSKGLLLVWDGERAEVYKVTETNDIMPASQFETTSRCMAINNDSVYRAAENKVEVVNMAGTVKQTLMFDDNHGSPTSMDVARDYLAVVTSANIVRILKVAGREAKPHAGPAPLCPPELKDWKVMAMRANGNGNLVAALVVGPEPARAVRLVVWCGETNTHHVHDFTPEGRQPVQLMFDTVEPKLLVVQCTPVFTEANVDERPHGDAAHVVDCAIIFVDPDKGILLQEYQPIHTGGATACIGSCAPHLLTNKKSMVQPAPGSGAFQPFTSNVSKAIMTSFQGMQDSDDKTRRALLDFSFNLATGNMDEAFRSVKAIKNPAVWENMAHMCIRNKRLDVAEHCLSNMEHARGARALREAKSIEEADARVATVAVHLGMIEDAKKLYIACERYDLLNQLYRACGQWDKALEVAEKNDRIHLKSTHYAYGQFMERQGDMEGARKHYEAAGCGLVEVPRMLFEAEKFTELQNYIQANDSRELILWWGKYLESLGEYAKALDCYRKAGDSLSMVRIHCFQRDWKAAEDEVTNSADNAASFHLARQYEASGRIPEAIRYYTLAKRYSHGVRLAKTHELDSDLMNLALKSTPAVMIDTADYLFAKGQHEKAATLYMKGGKLSKAVEMCFQAQLFDVLQHITDDMTPEKSDPNLYNKCAEFFMGFGHNDKAVKMLIAAQQYGRALELCVEHDVSITEEMADSMTPDKNAAVSADERNNVICRIAKVAKRQGNFQLAAKKYTQAGDKVKAMKALLRGGDAEKIIFFAGVSRQKDIYLMAANYLQTLNWHSDPELMKHIISFYTKAAAWESLASFYEACAQIEVDEYRDYEKALQAMREAAKYVAKSKNDDRDARVGVINDRIAVAEQFVAARQLIGSNPQEALRVCDELLRAIPPNSQDLEAGIRIGDVYALMVEYWYEARNPNEAYKAIEAMRRRGIILSPYLDTRMVEDIYRSLGVALDMAEERRGPANLGLRESDAGAFVEEEVADEDD
Protein: Pregnane X receptor (Q2V0W2)
Organism: Sus scrofa (Pig)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MQCNETDSTSGNSTTNADEEDEGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAIKRNARPRCLFRKGACEITRKTRRQCQACRLRKCLESGMRKEMIMSDAAVEQRRALIRRKKREQIGAQPPGAKGLTEEQRTMISELMNVQMKTFDTTFTHFKNFRLPEVLSSSLEIPECLQTPSSREEAAKWSKLREDLCSVKLSLQLRGEDGSVWNYKPPADNSGKEIFSLLPHIADMSTYMFKGIINFAKVISYFRDLPIEDQISLLKGATFELCQLRFNTVFNAETGTWECGRLSYSLEDPSGGFQQLLLQPMLKFHYMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRQVVDQLQERFAITLKAYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFSITES
Protein: CD3 glycoprotein (CD3D antigen delta) (CD3g/d protein) (Q90768)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MWKGRALGTWLLLACVAVAKLGVHGLSMSVKEVSGKVFLQCQESKDLNTNYLWKKGKEELGNMRQLDLGAIYDDPRGTYTCQRDENVNSTLHVHYRMCQNCIEVDAPTISGIVVADVVATVLLAIAVYCITGQDKGLMSRASDRQNLIANDQLYQPLGERNDGQYSQLATAKARK
Protein: Adenylate kinase 5 (Adenylate kinase isoenzyme 5 (EC 2.7.4.3)) (A5PMF1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Adenine phosphoribosyltransferase.
- Adenylosuccinate lyase
- Deoxycytidine kinase.
- Deoxycytidine kinase 2.
- Adenosine kinase
- Adenosine kinase b.
- Thiamine pyrophosphokinase
- Nucleoside-triphosphatase, cancer-related.
- Ectonucleotide pyrophosphatase/phosphodiesterase 1
- Tubulin polyglutamylase complex subunit 1
Sequence:
MNTNDAKEYLSRREIPQLFESLLTGLMYYRPDDPLEYLETCLKKVRDLGGTDKVRWDTFVGQEKKSLPPLNGGQSRRSFFRNVLPDSPNFPYRRYERLPPINQFSIESDSDLSETAELIEEYEVFDPSRPRPKVILIIGGPGSGKGTQCLKIAERYGFEYVSVGELLRKKMIHNATSNRKWSLIARIITNGELAPQETTITEIKQKIMKIPEASGIVIDGFPRDVGQALSFEDQVCTPDLVVFLACSNQRLKERLEKRAEQQGRPDDNPKAIDRRLTNFKQNAIPLVKYFQEKGLIVTLDADRDEEEVFYDISMTVDNKLFPTKEPVAGPSELDLSLIADSSSLTDVPAKFDEQADEEVAEYAEAIGESFPMETKKSKVIFVIGGPGSGKALQSEKIEERYSLKRLCPGDILCSELQSHSERGRFLRDLLERGEQLPEDTLLDLLCEAMASTVRQGKGFLVTGFPKNEKQAQEYEAKMGQPDIVLLLECSADIMSRRLQQRATCSLHSKEARDRDTRRRVDGFCSLINPVVAHYQHREFFHKIDAEQPPEDVFEHICVVLDSC
Protein: Dual endothelin-1/VEGF signal peptide receptor (DEspR protein) (Dual endothelin-1/VEGFsp receptor) (FBXW7 antisense RNA 1 homolog) (Q2QKR2)
Organism: Mus musculus (Mouse)
Function: Dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 v in a highly specific manner. Also binds the signal peptide of VEGFA. May play a role in angiogenesis with a significant role in cardiovascular and neural development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16293765}; Single-pass membrane protein {ECO:0000250|UniProtKB:B0L3A2, ECO:0000255}.
Interaction partners:
Sequence:
MNALYVTTVPKGYSSLSKCNHNEQDTAYRLWLCTHNHWTAPSGMRLQPLTSLGSKEMKSRWNWGSITCIICFTCVGSQLSMSSSKASNFSGPLQLYQRGIGHITNSYKRPQAPAWPCLSSGTMGRSH
Protein: Transcription factor bHLH160 (Basic helix-loop-helix protein 160) (AtbHLH160) (bHLH 160) (bHLH transcription factor bHLH160) (F4I8F9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- THO complex subunit 4D
- Copper transporter 3
Sequence:
MSSQPNHQTSISSLLHDRLHIPPAETIVEKESAEKDTCQSQRKRKEPVLHEVDGSSSGAAKKQDHNAKERLRRMRLHASYLTLGTLLPDHSSSSSKKKWSAPSIIDNVITYIPKLQNEVGELTLRKQKLVELERRGPSIRAISVLELGESGYEAVVQICLKKENEDEFSNLLHVMEVQGLSVLSASTSQVCREQRVVCYNFHVKMDEKPCEGDDYITVLKNNIISSLRDNTKCK
Protein: Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) (Scube/You) (Q9NQ36)
Organism: Homo sapiens (Human)
Function: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
Subcellular location: Secreted. Cell surface {ECO:0000269|PubMed:19480626}. Note=Secreted and tethered at the cell surface (PubMed:19480626). {ECO:0000269|PubMed:19480626}.
Interaction partners:
- DENN domain-containing protein 2B
- Sonic hedgehog protein
- Cathepsin L2
Sequence:
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
Protein: Glutathione S transferase E11, isoform A (Glutathione S transferase E11, isoform B (EC 2.5.1.18)) (LD18692p) (Q7JVZ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- glutathione transferase
- Bifunctional glutamate/proline--tRNA ligase
- GH16740p
- Glutathione S transferase T2
- Glutathione S-transferase D4
- Glutathione S transferase D11, isoform B
- Glutathione S transferase T1
- Glutathione S-transferase D1
- Glutathione S transferase O1
- Glutathione S-transferase E14
Sequence:
MSAKPILYYAPRSPPCRAVLLTAAALGLELDLRLVNVKAGEHKSAEFLKLNAQHTIPVLDDNGTIVSDSHIICSYLADKYAPEGDDSLYPKDPEKRRLVDARLYYDCGHLFPRIRFIVEPVIYFGAGEVPSDRVAYLQKAYDGLEHCLAEGDYLVGDKLTIADLSCIASVSTAEAFAPIEPDQFPRLVQWVKRIQALPYYQKNNQEGLDMLVGLVKGLLAERQQK
Protein: Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3) (Q99500)
Organism: Homo sapiens (Human)
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Sphingosine kinase 1
- Sphingosine kinase 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
Protein: Zinc finger RNA-binding protein (Q562A2)
Organism: Rattus norvegicus (Rat)
Function: Involved in postimplantation and gastrulation stages of development (By similarity). Binds to DNA and RNA (By similarity). Involved in the nucleocytoplasmic shuttling of STAU2.
Subcellular location: Nucleus {ECO:0000269|PubMed:16277607}. Cytoplasm {ECO:0000269|PubMed:16277607}. Cytoplasmic granule {ECO:0000269|PubMed:16277607}. Chromosome {ECO:0000250}. Note=Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules. Associated with chromosome foci in meiotic cells (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQARQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKTPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQVFILCIYHESQCTFTSVYSVLCNSPIDQKDACGKLHLCRLCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAVSASKPTASPSSIGASNCTLNTSSIATTSVKGLSTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINFVGGGNKLQSTGNKAEDLKGTDCIKNNPAASAVQIPEVKQDAVSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWRMEIRRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGVRPGMPPQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDSLSEHEKSKNKEGDDKKEGGKDRSLKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKSLLSRIAENLPKQLAVISPEKYDIKCAVSEAAIILNSCVEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGNPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMNQRFNIHNNRKRRRDSDGVDGFEAEGKKDKKDYDNF
Protein: Antigenic heat-stable 120 kDa protein (120 kDa antigen) (Protein PS 120) (B0BXR4)
Organism: Rickettsia rickettsii (strain Iowa)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MRGFMSKDGNLDTSEFDPLANKEYTEEQKQTLEQEQKEFLSQTTTPELEADDGFIVTSESSAQSTPSMSALSGNISPDSQTSDPITKAVRETIIQPQKDNLIEQILKDLAALTDRDLAEQKRKEIEEEKEKDKTLSTFFGNPANREFIDKALEKPELKKKLESIEIAGYKNVHNTFSAASGYPGGFKPVQWENHVSASDLRATVVKNDAGDELCTLNETTVKTKPFTLAKQDGTQVQISSYREIDFPIKLDQADGSMHLSMVALKADGTKPSKDKAVYFTAHYEEGPNGKPQLKEISSPKPLKFAGTGDDAIAYIEHGGEIYTLAVTRGKYKEMMKEVELNQGQSVDLSQAEDIIIGQGQSKEQPLITPQQTTSSSVEPPQYKQQVPPITPTNQPLQPETSQMPQSQHVNPNLLNAATALSGSMQYLLNYVNAGLTKEIDSNQQIDLIKEAATVILNNEKSDIAEKQANIIAFAENTVNNKNLKPDAKVAGVNAVLETIKNDQNTPDLEKSKMLEATVAIVLNSENLEPKQKQQVLDKAVDVGLSLKDDASRAAAIDGIKDVVIKSNLSTVMLIAVGDKVNVSELSNAEKQKLLGSVLKKGVEAQVLSPAQQQLMQQHLDKIMAEQTKKDTIKKVNDILFDPLSNTELKTTNIQAIISNVLDGPATAVVKGEIIQEITNTVAGSSLEAQDKATIVKGVGETIATHSDTSLSLPNKALIMASAEKGIAESQTTLPDRELMTKGLVDGIYEGKGGPEITKAVSSGIDNSNINDSEKEALKKAKDAASETALDRDTQNLTEGLKGQNIEEHKPHDDIYNKAREVINAVNPVIEALEKSKEPVVSAEARIVQETSSILNNISKLAVEKVNNFRAMLSPNGNLKTLEEKKEESIKKVDELVKAFGTKSSTAEQQSFIKTNLIDDKTLSKEVRLQTIDKLLQEQKRAEAIENPSVKTEDVRVVSGKSQLKPISKDNPDIEKAKMVVGRDRVNIKGNIKIMGALMNARDIIQSENLNKSTPIKRESSPPQR