wanglab/gogpt-training-data huggingface dataset:
Protein: Translation initiation factor, putative (Q57ZT3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Eukaryotic translation initiation factor 3 subunit L
- Translation initiation factor, putative
- CSN8/PSMD8/EIF3K domain-containing protein
- Elongation initiation factor 2 alpha subunit, putative
- RNA-binding protein, putative
- Eukaryotic translation initiation factor 3 subunit E
- protein-synthesizing GTPase
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit I
Sequence:
MEDDGLMSNIIIVNGLPARVTPEKRAMFLRHMTKKVSDVLGHDKFTIHPVLDEETEHVAGAFLTFATVNSAEDALARLNRFPFTKTDILSTYRWCALKAASEPPEEYKPPEMEQDTDADFAHTMAEDSMARPQFFIKQGESFDVEWYWFNYTTLKAELYRKPRPLKTDSVGQWTEMDRRQKRLDPGLVYGALTSVRPMPAWSTFGRIMVSQHMGGLKLWGGRKMHMLFEVTELDIKAFYISPQEKYLVVKSPKEVSVWNIRLSKKIRVLGGLDLADSDKWPIARYNAEDELVAISHACLEPMGQGKLFLYRAETMRALQVESNSETPVHSLVIPGLKVAEWNPAVGNQMAILVQGGSSEGWKIIIQNLVVKDDVVRAEVIEQRNFLQAQRLDLLWHPQGTHLVVKVTKTNSTEYSIFSVGVKSAAAYQLKVENGLTPGRFAWKPSGPHFAVICEDRARTGKLGDTSEIRIYCIKKQLKLIGHYPTSATHLFWAPRGSRLVATNYDKSTLHFYGINDSGACVQLERVTSPVTDTAWDPTGRFYAAWVSALRNSGDNQFRIFDLNGRELMQKSVRQLSHFAWRPLAPPVLTAAEIKHIQDNLREYSQRYQNEVKEQKEREEAELQSKEREKEEQYKKRMKGIARHHADKGLARTREELIASSRWSRLWARRMKSLPPEEMILHEVVTEERIERRRPLN
Protein: Cytochrome P450 (P-450 monooxygenase) (A0A2Z2PIS2)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Interaction partners:
Sequence:
MITSSISGTDQQFQNATQPKELDPDAVPVSRLDSEGHEIFAEWRPKRPFLRREDGVFLVLRADDIFLLGTDPRTRQIETELMLNRGVTRGAVFDLIRYSMLFSNGEVHVKRRSAFAKTFAFRMIDALRPEITKLTEHLWDDVPRVDDFDFAEMYASKLPALTIASVLGLPFGDAPFFTRLVYNVSRCLSPSWGEDDFPEIEASAVELQDYVRAVVADRSRRISDDFLSCYLKAVREEGTLSPIEEIMQLVFLILAGSDATRNAMVMLPTLLLQNPVVWSSLCHDQSGVAAAVEEGLRFEPSVGSFPRLALEDIDLDGYVLPKGSFLALSIMSGLRDERHYEHPQLFDIKRKQMRRHLGFGAGVHRCLGEALARIELQEGLRTLLRRAPSLRVTGDWPRMIGHGGARRATGMTVNLGVDR
Protein: Nuclear pore complex protein NUP96 (AtNUP96) (Nucleoporin 96) (Nucleoporin PRECOCIOUS) (Nucleoporin PRECOZ) (Protein MODIFIER OF SNC1 3) (Protein SUPPRESSOR OF AUXIN RESISTANCE 3) (Q8LLD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Contributes to the transfer of mature mRNA from the nucleus to the cytosol. Required for both R gene-mediated and basal disease resistance. RNA export seems to play a critical role in stress responses and regulation of plant growth and development.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:16751346}; Peripheral membrane protein {ECO:0000269|PubMed:16751346}; Nucleoplasmic side {ECO:0000269|PubMed:16751346}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15772285, ECO:0000269|PubMed:21203492}.
Interaction partners:
- Protein SEH1
- Protein transport protein SEC13 homolog B
- Nuclear pore complex protein NUP107
- Nuclear pore complex protein NUP160
- Protein RAE1
- Nuclear pore complex protein NUP85
- Nuclear pore complex protein NUP88
- F7H2.18 protein
- Nuclear pore complex protein NUP205
- Nuclear pore complex protein NUP54
Sequence:
MTSLSIQPFPEISRMARDLDSRKKRRISLDGIAALCEHSKEIIDSLPMLNSPDYFLKPCINELVEREIESPDYCSRVPDFTIGRIGYGYIRFLGNTDVRRLDLDHIVKFHRHEVIVYDDESSKPVVGEGLNKAAEVTLVVNIPDLTWGKQQVNHIAYKLKQSTERQGATFISFDPDNGLWKFFVPHFSRFGLSDDEAEDIAMDDAPGLGDPVGLDGKKVADIDEEDQMETSELELSHSLPAHLGLDPEKMKEMRMLMFPNEDEDESEDFREQTSHLMTSLTKRNVRPSQKIAQRNSHQDPPPVVRKTPLALLEYNPGNDKSSPGSILMVQQNKNLAVRKSKTGGFELDISHVTPLTDNYSRNVVDAALFMGRSFRAGWGPNGVLFHTGKPICSSSSQMVLSSVINKEKIAIDKVVWDRKGKVQKELIDSAFEAPLSLHKELNHVEEEVRFGSFSLKLQNVVTDRVVLSDICRSYIGIIEKQLEVAGLSTSAKLFLMHQVMVWELIKVLFSERQSTERLMYAASDNEEDVMQDVKEDSAKIDTEALPLIRRAEFSCWLQESVSHRVQEDVSDLNGSSYLEHLFFLLTGRELDSAVELAISKGDVRLACLLSQAGGSTVNRNDILQQLHLWRRNGLDFNFIEKERIKLYELLAGNIHDALQDFTIDWKRFLGLLMWHHLPPDSSLPIIFRSYQLLLNQAKAPWPVPIYIDEGPADGFVSDNKHSDILYYLMLLHSKEEEEFGFLQTMFSAFSSTDDPLDYHMIWHHRGILEAVGAFTSDDLHTLDMGFVAQLLSQGLCHWAIYVVLHIPFREDHPYLHVTVIREILFQYCETWSSMESQRQFIKDLGIPSEWMHEALAVYYNYHGDFVKALDQFIECANWQRAHSIFMTSVAHSLFLSANHSEIWRIATSMDDRKSEIENWDLGAGIYMSFYLLKSSLQEDADTMVELEPLDSTNESCRNFVGRLNESLAVWGDRLPVEARVAYSKMAEEICDLLLSDLSKNPSRETQLTCFETAFDAPLPEDVRSTHLQDAVSLFSLYLSETGQISA
Protein: Bud site selection protein 3 (P25558)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Co-assembles with BUD4 at bud sites. BUD4 and BUD3 may cooperate to recognize a spatial landmark (the neck filaments) during mitosis and they subsequently become a landmark for establishing the axial budding pattern in G1.
Interaction partners:
- Bud site selection protein 4
- Axial budding pattern protein 2
- Bud site selection protein 5
- Putative protease AXL1
- G2/mitotic-specific cyclin-2
- Inhibitory regulator protein BUD2/CLA2
- Cell division control protein 12
- Ras-related protein RSR1
- Cyclin-dependent kinase 1
- Bud site selection protein 9
Sequence:
MEKDLSSLYSEKKDKENDETLFNIKLSKSVVETTPLNGHSLFDDDKSLSDWTDNVFTQSVFYHGSDDLIWGKFFVCVYKSPNSNKLNAIIFDKLGTSCFESVDISSNSQYYPAIENLSPSDQESNVKKCIAVILLQRYPLLSPSDLSQILSNKSENCDYDPPYAGDLASSCQLITAVPPEDLGKRFFTSGLLQNRFVSSTLLDVIYENNESTIELNNRLVFHLGEQLEQLFNPVTEYSPEQTEYGYKAPEDELPTESDDDLVKAICNELLQLQTNFTFNLVEFLQKFLIALRVRVLNEEINGLSTTKLNRLFPPTIDEVTRINCIFLDSLKTAIPYGSLEVLKACSITIPYFYKAYTRHEAATKNFSKDIKLFIRHFSNVIPEREVYTEMKIESIIKGPQEKLLKLKLIIERLWKSKKWRPKNQEMAKKCYNNIIDVIDSFGKLDSPLHSYSTRVFTPSGKILTELAKCWPVELQYKWLKRRVVGVYDVVDLNDENKRNLLVIFSDYVVFINILEAESYYTSDGSNRPLISDILMNSLINEVPLPSKIPKLKVERHCYIDEVLVSILDKSTLRFDRLKGKDSFSMVCKLSSAFISSSSVADLITKARILEKDTAFHLFKASRSHFTLYSTAHELCAYDSEKIKSKFALFLNIPPSKEILEVNNLHLAFFARFCSNDGRDNIVILDVLTKHDDKHIEVTSDNIVFTIINQLAIEIPICFSSLNSSMAKDLLCVNENLIKNLEHQLEEVKHPSTDEHRAVNSKLSGASDFDATHEKKRSYGTITTFRSYTSDLKDSPSGDNSNVTKETKEILPVKPTKKSSKKPREIQKKTKTNASKAEHIEKKKPNKGKGFFGVLKNVFGSKSKSKPSPVQRVPKKISQRHPKSPVKKPMTSEKKSSPKRAVVSSPKIKKKSTSFSTKESQTAKSSLRAVEFKSDDLIGKPPDVGNGAHPQENTRISSVVRDTKYVSYNPSQPVTENTSNEKNVEPKADQSTKQDNISNFADVEVSASSYPEKLDAETDDQIIGKATNSSSVHGNKELPDLAEVTTANRVSTTSAGDQRIDTQSEFLRAADVENLSDDDEHRQNESRVFNDDLFGDFIPKHYRNKQENINSSSNLFPEGKVPQEKGVSNENTNISLKTNEDASTLTQKLSPQASKVLTENSNELKDTNNEGKDAKDIKLGDDYSDKETAKEITKPKNFVEGITERKEIFPTIPRLAPPASKINFQRSPSYIELFQGMRVVLDKHDAHYNWKRLASQVSLSEGLKVNTEEDAAIINKSQDDAKAERMTQISEVIEYEMQQPIPTYLPKAHLDDSGIEKSDDKFFEIEEELKEELKGSKTGNEDVGNNNPSNSIPKIEKPPAFKVIRTSPVRIIGRTFEDTRKYENGSPSDISFTYDTHNNDEPDKRLMELKFPSQDEIPDDRFYTPAEEPTAEFPVEELPNTPRSINVTTSNNKSTDDKLSSGNIDQKPTELLDDLEFSSFNIAFGNTSMSTDNMKISSDLSSNKTVLGNAQKVQESPSGPLIYVLPQSSTKHEKEGFLRKKQKDEPIWVSPSKIDFADLSRRTKALTPERNTVPLKNNDSRKYKYTGEGSIGNMTNMLLTKDASYAYLKDFVALSDDEDEDGKQNCAVGGPEKLKFY
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (H0YJF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSEESQGAIHRSMSQPEASSSSYDSSRTRKRVQK
Protein: Inhibitor/interactor with cyclin-dependent kinase (F4K388)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MGKYMKKSKITGDISVMEVSKATAPSPGVRTRAAKTLALKRLNSSAADSALPNDSSCYLQLRSRRLEKPSSLIEPKQPPRVHRSGIKESGSRSRVDSVNSVPVAQSSNEDECFDNFVSVQVSCGENSLGFESRHRFVVFFFFFLFFMFPLLVCTRESTPCNFVEDMEIMVTPGSSTRSMCRATKEYTREQDNVIPTTSEMEEFFAYAEQQQQRLFMEKYNFDIVNDIPLSGRYEWVQVKP
Protein: Parvalbumin beta 2 (P86432)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Interaction partners:
Sequence:
SFAGLNDADVAAALAACAAADSFNHKAFFAKXXXXXXSPDDLKKXXXXLDQDKSGFLEEDELKLFLQNFSASARALTDAETKXXXXAGDADGDGMLGLDEFAVLVKQ
Protein: RNA-binding motif protein 14b (RNA-binding protein 14b) (Zgc:85696) (Q6NV05)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Tmem50a protein
- EWS RNA-binding protein 1b.
Sequence:
MDKGHTVKLFVGNLALDTTQEELSAIFESYGQVVSCSVLRQFAFVHLQGEGAAERAIRELNGREFKGRNLVVEESRGRPLHSTKVFVGNLSSMCTTEDLQELFQTFGKVLECDKVKGYAFVHMENKEDALQAIEALHGTSFKGRPLSVELSKVQPSKQTPTGKIPCVSCGKQGHYAGECPAGKPTLEQYQSQAAVLAAAAAAAAGLPLQVQQSVHNSVYNTSTFDPTYAALTGLTAAGARAEGGAAVAPAVYGALASQVYGTAVANQLYGGSVANQALNSSAAAAAAQAYGSVNPALYGQMTSGAVAAAAAAAAAYGPQVYTQAVGNPVFLTAAPSMEVPAGAAAVNPAYTVAPALYSATPAYGALGAADPAAIFEAARAHYFAQGQQVLAEQQQASSKSGERDRSPLRRSAPLLPDPVMKPFIYQRAKRRALLPTPAGREEAAAQEDDPVARYYAEYYQQYQQLQQYPQYQYAYPAHSALAAMSALQSLPGVSAQQVATLDSLRPVLPAAPVPAAAAIAMATPRVYEPPPIPPSHKEPLLRRPELALHTPETPFR
Protein: Bcl-2-like protein 1 (Apoptosis regulator Bcl-X) (A0A0S2Z3D2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004432}. Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}. Nucleus membrane {ECO:0000256|ARBA:ARBA00004528}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004528}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004528}.
Interaction partners:
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQILLWNSMGTMQQPRAERARNASTAGS
Protein: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (Q8ILU6)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03166}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03166}.
Interaction partners:
- Surface-related antigen SRA
- CPSF, subunit A, putative
- Apurinic-apyrimidinic endonuclease 1
- Bifunctional dihydrofolate reductase-thymidylate synthase
- DNA-
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Spindle assembly abnormal protein 6, putative
- histidine--tRNA ligase
- histidine--tRNA ligase
- Proliferating cell nuclear antigen 2
Sequence:
MNNPTIQKTIDQFFKVKRKSSILSGEIEKKRKKVILEEVEEKSLEGSLKEENVNILKTKKLMNNDEDIEKMGTISNISMSTSTIDNEINNNVKQNVCEQGYMEEIKKLMHIEWYELLKDELKKNYFKNMYLKIKEERKTKVIYPPEQLVFNAFLKTPLSNIKVVIVGQDPYHQKDQAMGLCFSVPIGVKIPPSLKNILKEMKQKSNHGNLISWSEQGVFLLNTSLTVEENKPASHKNYGWETFTDTVINIINRQKEKIIFMLWGNFAIKKCKNIDINKHFILKAGHPSPLSIKHFENCNHFAKCNKILAQHNLTPIKWELPQ
Protein: P-type cation-transporting ATPase (EC 7.2.2.21) (Cadmium resistance protein 2) (Cadmium-translocating P-type ATPase) (Cd(2+)-exporting ATPase) (P38360)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium. Capable of high affinity copper ion binding, but not active copper ion transport. May play a role in copper resistance by chelating and sequestering copper ions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17107946}; Multi-pass membrane protein {ECO:0000269|PubMed:17107946}.
Interaction partners:
- Superoxide dismutase 1 copper chaperone
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-7
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-2
- Proteasome subunit beta type-5
- Proteasome subunit alpha type-5
Sequence:
MKPEKLFSGLGTSDGEYGVVNSENISIDAMQDNRGECHRRSIEMHANDNLGLVSQRDCTNRPKITPQECLSETEQICHHGENRTKAGLDVDDAETGGDHTNESRVDECCAEKVNDTETGLDVDSCCGDAQTGGDHTNESCVDGCCVRDSSVMVEEVTGSCEAVSSKEQLLTSFEVVPSKSEGLQSIHDIRETTRCNTNSNQHTGKGRLCIESSDSTLKKRSCKVSRQKIEVSSKPECCNISCVERIASRSCEKRTFKGSTNVGISGSSSTDSLSEKFFSEQYSRMYNRYSSILKNLGCICNYLRTLGKESCCLPKVRFCSGEGASKKTKYSYRNSSGCLTKKKTHGDKERLSNDNGHADFVCSKSCCTKMKDCAVTSTISGHSSSEISRIVSMEPIENHLNLEAGSTGTEHIVLSVSGMSCTGCESKLKKSFGALKCVHGLKTSLILSQAEFNLDLAQGSVKDVIKHLSKTTEFKYEQISNHGSTIDVVVPYAAKDFINEEWPQGVTELKIVERNIIRIYFDPKVIGARDLVNEGWSVPVSIAPFSCHPTIEVGRKHLVRVGCTTALSIILTIPILVMAWAPQLREKISTISASMVLATIIQFVIAGPFYLNALKSLIFSRLIEMDLLIVLSTSAAYIFSIVSFGYFVVGRPLSTEQFFETSSLLVTLIMVGRFVSELARHRAVKSISVRSLQASSAILVDKTGKETEINIRLLQYGDIFKVLPDSRIPTDGTVISGSSEVDEALITGESMPVPKKCQSIVVAGSVNGTGTLFVKLSKLPGNNTISTIATMVDEAKLTKPKIQNIADKIASYFVPTIIGITVVTFCVWIAVGIRVEKQSRSDAVIQAIIYAITVLIVSCPCVIGLAVPIVFVIASGVAAKRGVIFKSAESIEVAHNTSHVVFDKTGTLTEGKLTVVHETVRGDRHNSQSLLLGLTEGIKHPVSMAIASYLKEKGVSAQNVSNTKAVTGKRVEGTSYSGLKLQGGNCRWLGHNNDPDVRKALEQGYSVFCFSVNGSVTAVYALEDSLRADAVSTINLLRQRGISLHILSGDDDGAVRSMAARLGIESSNIRSHATPAEKSEYIKDIVEGRNCDSSSQSKRPVVVFCGDGTNDAIGLTQATIGVHINEGSEVAKLAADVVMLKPKLNNILTMITVSQKAMFRVKLNFLWSFTYNLFAILLAAGAFVDFHIPPEYAGLGELVSILPVIFVAILLRYAKI
Protein: Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) (Q5HYN5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:31429579}.
Interaction partners:
- Cancer/testis antigen family 45 member A5
- Cancer/testis antigen family 45 member A10
Sequence:
MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKAKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETASSPKSQREINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI
Protein: Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein (Q59U89)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Asr2p
- Meiotic sister chromatid recombination protein 1
- Glyoxalase 3
- Asr1p
- Transmembrane protein
- Uncharacterized protein
- Hsp12p
- Antisense-enhancing sequence 1
Sequence:
MAKTSPHKLFYKGAENDFVIFIDDADLLAKYKKEFSTKGSSTIPIIDLVSIFKVFINRQRGAEGILDEAAKSDLENEFKTSNADQVIKIILEKGEDKSKTGSIGEIGGSHNDSIGNGDAAN
Protein: Superoxide dismutase (EC 1.15.1.1) (Q5A8Z4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Superoxide dismutase
- Mitochondrial 37S ribosomal protein RSM26
- Superoxide dismutase
- Mitochondrial 37S ribosomal protein MRP1
- Peroxisomal catalase
- Succinate--CoA ligase subunit alpha, mitochondrial
- Thiosulfate sulfurtransferase
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL29m
- Mitochondrial 37S ribosomal protein MRPS17
Sequence:
MFSIRSSSRVLLKASSATTRATLNAAASKTFTRSKYSLPELDYEFSATEPYISGQINEIHYTKHHQTYVNNLNASIEQAVEAKSKGEVKKLVALQKAINFNGGGYLNHCLWWKNLAPVSQGGGQPPSEDSKLGKQIVKQFGSLDKLIEITNGKLAGIQGSGWAFIVKNKANGDTIDVITTANQDTVTDPNLVPLIAIDAWEHAYYLQYQNVKADYFKNLWHVINWKEAERRFEF
Protein: Leucine-rich repeat, isoform F (A0A0B4KEE7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
- Polychaetoid, isoform O
- Caspase-1
- Ankyrin, isoform B
- Amun, isoform A
- Ankyrin 2, isoform U
Sequence:
MSTRSQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEETLVEELQQSMATRRGFRDSTYTKEDVVDL
Protein: CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27) (Q96JB5)
Organism: Homo sapiens (Human)
Function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1. Required for liver development (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. Cytoplasm {ECO:0000269|PubMed:15790566, ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:19223857}. Nucleus {ECO:0000269|PubMed:16173922}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19223857}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23478299}. Note=Tethered to the endoplasmic reticulum membrane as part of the UFM1 ribosome E3 ligase (UREL) complex (PubMed:38383785, PubMed:38383789). Colocalizes and associates with microtubules (PubMed:23478299). {ECO:0000269|PubMed:23478299, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}.
Interaction partners:
- E3 UFM1-protein ligase 1
- DDRGK domain-containing protein 1
- Cyclin-dependent kinase 5
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- Cyclin-dependent kinase 5 activator 1
- Ufm1-specific protease 2
- Ubiquitin-fold modifier-conjugating enzyme 1
- Ubiquitin-fold modifier 1
- Transmembrane emp24 domain-containing protein 3
- Ubiquitin-like modifier-activating enzyme 5
Sequence:
MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVLTIREKINAAIQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL
Protein: Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] (P03363)
Organism: Human T-cell leukemia virus 2 (HTLV-2)
Function: The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.
Subcellular location: [Matrix protein p19]: Virion {ECO:0000250|UniProtKB:P03345}.; SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000250|UniProtKB:P03345}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p15-pro]: Virion {ECO:0000250|UniProtKB:P03345}.
Interaction partners:
Sequence:
MGQIHGLSPTPIPKAPRGLSTHHWLNFLQAAYRLQPRPSDFDFQQLRRFLKLALKTPIWLNPIDYSLLASLIPKGYPGRVVEIINILVKNQVSPSAPAAPVPTPICPTTTPPPPPPPSPEAHVPPPYVEPTTTQCFPILHPPGAPSAHRPWQMKDLQAIKQEVSSSALGSPQFMQTLRLAVQQFDPTAKDLQDLLQYLCSSLVVSLHHQQLNTLITEAETRGMTGYNPMAGPLRMQANNPAQQGLRREYQNLWLAAFSTLPGNTRDPSWAAILQGLEEPYCAFVERLNVALDNGLPEGTPKEPILRSLAYSNANKECQKILQARGHTNSPLGEMLRTCQAWTPKDKTKVLVVQPRRPPPTQPCFRCGKVGHWSRDCTQPRPPPGPCPLCQDPSHWKRDCPQLKPPQEEGEPLLLDLPSTSGTTEEKNLLKGGDLISPHPDQDISILPLIPLRQQQQPILGVRISVMGQTPQPTQALLDTGADLTVIPQTLVPGPVKLHDTLILGASGQTNTQFKLLQTPLHIFLPFRRSPVILSSCLLDTHNKWTIIGRDALQQCQGLLYLPDDPSPHQLLPIATPNTIGLEHLPPPPQVDQFPLNLPERLQALNDLVSKALEAGHIEPYSGPGNNPVFPVKKPNGKWRFIHDLRATNAITTTLTSPSPGPPDLTSLPTALPHLQTIDLTDAFFQIPLPKQYQPYFAFTIPQPCNYGPGTRYAWTVLPQGFKNSPTLFEQQLAAVLNPMRKMFPTSTIVQYMDDILLASPTNEELQQLSQLTLQALTTHGLPISQEKTQQTPGQIRFLGQVISPNHITYESTPTIPIKSQWTLTELQVILGEIQWVSKGTPILRKHLQSLYSALHGYRDPRACITLTPQQLHALHAIQQALQHNCRGRLNPALPLLGLISLSTSGTTSVIFQPKQNWPLAWLHTPHPPTSLCPWGHLLACTILTLDKYTLQHYGQLCQSFHHNMSKQALCDFLRNSPHPSVGILIHHMGRFHNLGSQPSGPWKTLLHLPTLLQEPRLLRPIFTLSPVVLDTAPCLFSDGSPQKAAYVLWDQTILQQDITPLPSHETHSAQKGELLALICGLRAAKPWPSLNIFLDSKYLIKYLHSLAIGAFLGTSAHQTLQAALPPLLQGKTIYLHHVRSHTNLPDPISTFNEYTDSLILAPLVPLTPQGLHGLTHCNQRALVSFGATPREAKSLVQTCHTCQTINSQHHMPRGYIRRGLLPNHIWQGDVTHYKYKKYKYCLHVWVDTFSGAVSVSCKKKETSCETISAVLQAISLLGKPLHINTDNGPAFLSQEFQEFCTSYRIKHSTHIPYNPTSSGLVERTNGVIKNLLNKYLLDCPNLPLDNAIHKALWTLNQLNVMNPSGKTRWQIHHSPPLPPIPEASTPPKPPPKWFYYKLPGLTNQRWKGPLQSLQEAAGAALLSIDGSPRWIPWRFLKKAACPRPDASELAEHAATDHQHHG
Protein: Taste receptor type 2 member 19 (Taste receptor type 2 member 23) (Taste receptor type 2 member 48) (T2R48) (P59542)
Organism: Homo sapiens (Human)
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Taste receptor type 1 member 3
- Taste receptor type 1 member 1
- Taste receptor type 1 member 2
Sequence:
MMCFLLIISSILVVFAFVLGNVANGFIALVNVIDWVNTRKISSAEQILTALVVSRIGLLWVMLFLWYATVFNSALYGLEVRIVASNAWAVTNHFSMWLAASLSIFCLLKIANFSNLISLHLKKRIKSVVLVILLGPLVFLICNLAVITMDERVWTKEYEGNVTWKIKLRNAIHLSSLTVTTLANLIPFTLSLICFLLLICSLCKHLKKMRLHSKGSQDPSTKVHIKALQTVTSFLMLFAIYFLCIITSTWNLRTQQSKLVLLLCQTVAIMYPSFHSFILIMGSRKLKQTFLSVLWQMTR
Protein: Protein phosphatase 1, regulatory subunit 9A (H3BKE7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAIIAKTRGKGRPSSPQRRMKPKEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSVHESGQNHRYSPKKEKGGGTEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSEPPGALTSGKAESADYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSKPPSNKQDTDTEDAQKSDAVPVPEVAQKGTSLASLPSEESQLSTEAEDVTTAQPEALDSTDKDSPEEPSAENQAMPKSHILSPRNEPLEDAEANVVGSERAQHQKKDLTGGDLTSPDASASSCGREVPEDSNSFESSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENNYYQPDMEYSEIVGLPEEEEIPANRKIKFSCAPIKDKFTGSGPRSSALHSPSHRIHSCWTLSAQCWDTESSAADACSPLLPTSQARAHHGVFGATLGSLQCY
Protein: Family with sequence similarity 120 member A (A0A0C4DH52)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHVPPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPGSSTSSSSDNDEGSGGATNHISGNKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPECMYCNNPLFVFLGTS