wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (GFAT) (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (Hexosephosphate aminotransferase) (P14742)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
Interaction partners:
- Glucosamine 6-phosphate N-acetyltransferase
- UDP-N-acetylglucosamine pyrophosphorylase
- Phosphoacetylglucosamine mutase
- Glucose-6-phosphate isomerase
- Glutamine synthetase
- Mannose-6-phosphate isomerase
- Glutamate synthase
- Hexokinase-1
- Glucokinase-1
- Hexokinase-2
Sequence:
MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
Protein: bMERB domain-containing protein 1 (Uncharacterized protein C16orf45 homolog) (Q8R1Y2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MELKQSLSVHLEAEKPLRRYGAVEETAWKAEGLGSQLDIISMAETSMMPEEIELEMAKIQRLREVLVRRESELRFMMDDIQLCKDIMDLKQELQNLVAIPEKEKTKLQKQREDELIQKIHRLVQKRDFLVDDAEVERLREQEEDKEMADFLRIKLKPLDKVTKTSASSRAEKKAEPPPSKPTVAKTGLALIKDCCGTTQCNIM
Protein: NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (Q2F8Z6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000471}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYIAVPAEILCLILPLLLGVAFLVLAERKVMAFVQRRKGPDVVGSFGLLQPLADGLKLILKEPISPSSANFSLFRMAPVATFMLSLVAWAVVPFDYGMVLSDPNIGLLYLFAISSLGVYGIIIAGWSSNSKYAFLGALRSAAQMVPYEVSIGLILITVLICVGPCNSSEIVMAQKQIWSGIPLFPVLVMFFIPCLAETNRAPSDLPEAEAESVAGYNVEYASMGSALFFLGEYANMILMRGLCTSLFPGGWPPILDLPISKKIPCSIWFSIKVLLFLFLYIWVRAAFPRYRYDQLMGLGRKVFLPLSLARVVPVSGVSVTFRWLP
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (Q8VIA0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGRVPLAWCVALCCWGCAAPKDTQTEADSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVMWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVAGYSFQHSLQAPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHNLHVVSRHPTELEVAWIPTLSGIYPLTHCTLQAVLSNDGVGVWLGKSDPPEEPLTVQVSVPPHQLRLEKLLPHTPYHIRVSCTSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQALVRWQEPREPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVAAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPPAFSWPWWYVLLGALVAAACVLILTLFLVHRRKKETRYGEVFEPTVERGELVVRYRARKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPLDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDYCSCLTAADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA
Protein: pH-sensitive adenylate cyclase Rv1264 (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (P9WMU9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the formation of the second messenger cAMP.
Interaction partners:
- cAMP/cGMP dual specificity phosphodiesterase Rv0805
- Pyruvate kinase
- Nucleoside diphosphate kinase
- Bifunctional
- Putative amidase AmiB2
- Riboflavin biosynthesis protein RibBA
- GTP 3',8-cyclase 2
- GTP 3',8-cyclase 1
- 3,4-dihydroxy-2-butanone-4-phosphate synthase
- GTP cyclohydrolase 1
Sequence:
MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP
Protein: Nuclear factor Y-box B, isoform A (Nuclear factor Y-box B, isoform B) (RE06807p) (RH50436p) (Q8ST61)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Nuclear transcription factor Y subunit
- Nuclear transcription factor Y subunit gamma
- Chromatin accessibility complex 16kD protein
- Grain, isoform C
- DNA polymerase epsilon subunit 4
- TATA-box-binding protein
- Negative cofactor 2alpha
Sequence:
MSNSEDSQQYLNDMLVKEEDEASGDDSDKQDGGIMLREQDRFLPICNIIKIMKVPVPQNGKIAKDARECIQECVSEFISFISSEAIERSVAENRKTVNGDDLLVAFSNLGFDNYVEPLSIYLQKYRESNKSDRNLFLDASYPHNEDGSSANDAGKQ
Protein: Transmembrane protein (Q9C636)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At3g04760
- At3g22970
- Probable inactive receptor kinase At1g27190
- Membrane-anchored ubiquitin-fold protein 3
- Alpha-crystallin domain 32.1
- Coiled-coil protein
- Putative leucine-rich repeat receptor-like protein kinase At2g19210
- Proline-rich receptor-like protein kinase PERK12
- Expressed protein
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
Sequence:
MHAKTDSEVTSLAASSPARSPRRPVYYVQSPSRDSHDGEKTATSFHSTPVLSPMGSPPHSHSSMGRHSRESSSSRFSGSLKPGSRKVNPNDGSKRKGHGGEKQWKECAVIEEEGLLDDGDRDGGVPRRCYVLAFIVGFFILFGFFSLILYGAAKPMKPKITVKSITFETLKIQAGQDAGGVGTDMITMNATLRMLYRNTGTFFGVHVTSTPIDLSFSQIKIGSGSVKKFYQGRKSERTVLVHVIGEKIPLYGSGSTLLPPAPPAPLPKPKKKKGAPVPIPDPPAPPAPVPMTLSFVVRSRAYVLGKLVQPKFYKKIECDINFEHKNLNKHIVITKNCTVTTV
Protein: Mitochondrial DNA repair protein recA homolog (Recombinase A homolog) (Q75JL2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in DNA recombination ability. Important for survival following exposure to DNA damaging agents.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15084313}.
Interaction partners:
- DNA helicase
- Flap endonuclease 1
- DNA 3'-5' helicase
- ABC transporter AbcH.3
- Uncharacterized protein
- DNA repair protein RAD51 homolog 3
- AAA ATPase domain-containing protein
- Replication protein A subunit
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Sequence:
MSINKILSSTYKITQRSNNNNILFNGLKINSFSLCNTKTNLFTNKTNINLYNNYSKSSKSGKKSKKDEDDEDGEIETSKTSKKSASSSSMENVLKELEKSFGKGTLMKLGSQFSTQKVEVIPSGSMGLDIALGVGGLPKGRVTEIFGPESSGKTTLALHVIAQAQKAGGNCTFIDAEHALNPQWAARLGVNLDELFVSQPDNGEQALEIVDSLLRSKTMSVIVVDSVAALVPRVEIEGEMGDSHLGVQARLMSQALRKLSPTLKDSNCVLIFINQIRMKIGVMFGNPEVTSGGNALKFFSSIRIDIRKVGTVKKGDDIIASQVKAKVVKNKLAPPFKEAIFDIDFQSGINKTGEIIDLAVAEGIIDKMGSWYSYNDIKLDQGREKTKYLLEKTQPNLLVEIENKLRDKLIKSKPLINQQQEEEGNDQTSDEFDIENDDEIIEEDIDDETIKK
Protein: Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (Q7KZS0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYWLVAALAPLVAAPPRPSQGRLAGREWSTQAHPRDSQGPRLCGEGRGA
Protein: NAC domain-containing protein 10 (ANAC010) (Protein SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 3) (F4HY61)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that plays a regulatory role in the development of secondary cell wall fibers. Is a direct target of SND1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:18952777}.
Interaction partners:
- Transcription factor MYB63
- MYB transcription factor
- Transcription factor MYB52
- Transcription factor MYB46
- Homeobox protein knotted-1-like 7
- MYB transcription factor
- Transcription factor MYB80
- Transcription factor MYB83
- Transcription factor
- MYB transcription factor
Sequence:
MSWCDGSDDNYDLNLERVSNTDHPSVQLKDQSQSCVTSRPDSKISAETPITTCPSCGHKLHHHQDDQVGSIKDLPSLPAGVKFDPSDKEILMHLEAKVSSDKRKLHPLIDEFIPTLEGENGICYTHPEKLPGVSKDGQVRHFFHRPSKAYTTGTRKRRKVSTDEEGHETRWHKTGKTRPVLSQSGETGFKKILVLYTNYGRQKKPEKTNWVMHQYHLGSSEDEKDGEPVLSKVFYQTQPRQCGSMEPKPKNLVNLNRFSYENIQAGFGYEHGGKSEETTQVIRELVVREGDGSCSFLSFTCDASKGKESFMKNQ
Protein: Kinesin family member 1A (A0A8I6A6V5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004250}.
Interaction partners:
Sequence:
MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAVPPEGLLDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRVSFGNDTRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETTQRPVPEVLSPASSEDSESRSSSGASSPLSAEGQPSPLEVPNERQRELAVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
Protein: Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) (Q6PGN3)
Organism: Mus musculus (Mouse)
Function: Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16628014, ECO:0000269|PubMed:16684769}. Note=Colocalizes with microtubules.
Interaction partners:
Sequence:
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSISGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISNDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNVNPNWSVNIKGGTTRTLAVASAKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSECRVLKSSYSRASAAKYSGSRSPGFSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAQGRSSSNVNGGPELDRCLSPEGVNGNRCSESFPLLEKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKLCQDSSRPSREQTSPVPPSAQEAPPPLESPRPPGPPATSGCDLAGTWRRHRD
Protein: TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) (O75674)
Organism: Homo sapiens (Human)
Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).
Subcellular location: Golgi apparatus, Golgi stack. Endosome membrane {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=A small proportion is membrane-associated. {ECO:0000250}.
Interaction partners:
- Clathrin heavy chain 1
- Toll-interacting protein
- Zinc finger FYVE domain-containing protein 16
- Tumor susceptibility gene 101 protein
- Clathrin heavy chain 2
- Growth factor receptor-bound protein 2
Sequence:
MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSPSPRMPRATLGELNTMNNQLSGLNFSLPSSDVTNNLKPSLHPQMNLLALENTEIPPFAQRTSQNLTSSHAYDNFLEHSNSVFLQPVSLQTIAAAPSNQSLPPLPSNHPAMTKSDLQPPNYYEVMEFDPLAPAVTTEAIYEEIDAHQHKGAQNDGD
Protein: Sodium/hydrogen exchanger (A0A087WXD1)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATEKEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVFPLEDNA
Protein: FI07208p (Midkine and pleiotrophin 2, isoform A) (Midkine and pleiotrophin 2, isoform F) (Midkine and pleiotrophin 2, isoform G) (Q9W0S4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNLILALTTALHLVLVVLAHNPLSTRGESLSDGIRLVMEKRSGDVVHIRPARGTLEAETVASTTNSDTHRTRNNRKPNKPQEHSQQVGAHKSGSRKLVVAENGGALSSQLPQPNHKQGHKNTDKQQRGGGSKQQRGHSQHHGGNRKGPKAATPENGSTCRYAKSAWSNCDHKTNMRSRVLSLRKGEQNCLPTRTIQKKCKKGCRYEKGEWSQCVGGQITREDKLEPEATGGSDQNCNPVRTVSKKCKANGNSSGGKQHGQSRRTKEQKQKDKGASHISS
Protein: Mitogen-activated protein kinase HOG1 (MAP kinase HOG1) (EC 2.7.11.24) (Q92207)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.
Interaction partners:
- Transcriptional regulator SKO1
- mitogen-activated protein kinase kinase
- protein-tyrosine-phosphatase
- Tyrosine protein phosphatase
- Type 2C protein phosphatase
- Stress-responsive transcriptional activator
- High osmolarity signaling protein SHO1
- Transcription factor SKN7
- Transcription activator GCR1-like domain-containing protein
- Oxidative stress response two-component system protein SSK1
Sequence:
MSADGEFTRTQIFGTVFEITNRYTELNPVGMGAFGLVCSAVDRLTGQNVAVKKVMKPFSTSVLAKRTYRELKLLKHLKHENLITLDDIFISPLEDIYFVNELQGTDLHRLLNSRPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLARLQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMIEGKPLFPGKDHVHQFSIITELLGSPPADVIDTICSENTLRFVQSLPHRDPIPFSERFASCTHVEPEAIDLLAKLLVFDPKKRISAVEGLTHPYMEAYHDPTDEPVCESKFDWSFNDADLPVDTWRVMMYSEILDFHQTVGVANETEGSEQPDSQVEQNNLDSANGA
Protein: DNA-directed RNA polymerase subunit Rpo10 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit N) (P39472)
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00250}.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo3
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase subunit Rpo7
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo11
- DNA-directed RNA polymerase subunit Rpo2
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo1N
- DNA-directed RNA polymerase subunit Rpo4
Sequence:
MIIPIRCFTCGAVVADKWEPFSNRVMGGEDPEKVLTELGVNRYCCRRMLLSHVNIIREIIHYTRPI
Protein: Alpha-galactosidase 2 (AtAGAL2) (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase 2) (Melibiase) (Q8RX86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:16845526}. Secreted, extracellular space, apoplast {ECO:0000269|PubMed:22363647}.
Interaction partners:
- Probable galactinol--sucrose galactosyltransferase 1
- Probable galactinol--sucrose galactosyltransferase 6
- Probable galactinol--sucrose galactosyltransferase 2
- Probable galactinol--sucrose galactosyltransferase 5
- alpha-D-xyloside xylohydrolase
- Probable galactinol--sucrose galactosyltransferase 4
- beta-galactosidase
- Beta-hexosaminidase 2
- Beta-hexosaminidase 1
- Aldose 1-epimerase
Sequence:
MVLLSFSLRFIAFTLTITLTQIADGFQSRMLMNNGLALSPQMGWNSWNHFQCNINETLIKQTADAMVSSGLSAIGYKYINIDDCWGELKRDSQGSLVAKASTFPSGIKALSDYVHSKGLKLGIYSDAGTLTCSQTMPGSLGHEEQDAKTFASWGIDYLKYDNCENTGTSPRERYPKMSKALLNSGRSIFFSLCEWGQEDPATWAGDIGNSWRTTGDIQDNWKSMTLIADQNDRWASYARPGSWNDPDMLEVGNGGMTKEEYMSHFSIWALAKAPLLIGCDLRSMDKVTFELLSNKEVIAVNQDKLGIQGKKVKKEGDLEVWAGPLSKKRVAVILWNRGSASANITARWAEIGLNSSDIVNARDLWEHSTYSCVKKQLSALVEPHACKMYTLTRRKA
Protein: Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (2-methoxy-6-polyprenolphenol 4-hydroxylase) (EC 1.14.15.-) (Ubiquinone C4-deaminase) (EC 3.5.-.-) (P53318)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6. Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process. HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:12721307, ECO:0000269|PubMed:14576278}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:12721307}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:12721307}.
Interaction partners:
- 5-demethoxyubiquinone hydroxylase, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis protein COQ4, mitochondrial
- Atypical kinase COQ8, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Ubiquinone biosynthesis protein COQ9
- Hexaprenyl pyrophosphate synthase, mitochondrial
- MIOREX complex component 2
- Adrenodoxin homolog, mitochondrial
Sequence:
MFFSKVMLTRRILVRGLATAKSSAPKLTDVLIVGGGPAGLTLAASIKNSPQLKDLKTTLVDMVDLKDKLSDFYNSPPDYFTNRIVSVTPRSIHFLENNAGATLMHDRIQSYDGLYVTDGCSKATLDLARDSMLCMIEIINIQASLYNRISQYDSKKDSIDIIDNTKVVNIKHSDPNDPLSWPLVTLSNGEVYKTRLLVGADGFNSPTRRFSQIPSRGWMYNAYGVVASMKLEYPPFKLRGWQRFLPTGPIAHLPMPENNATLVWSSSERLSRLLLSLPPESFTALINAAFVLEDADMNYYYRTLEDGSMDTDKLIEDIKFRTEEIYATLKDESDIDEIYPPRVVSIIDKTRARFPLKLTHADRYCTDRVALVGDAAHTTHPLAGQGLNMGQTDVHGLVYALEKAMERGLDIGSSLSLEPFWAERYPSNNVLLGMADKLFKLYHTNFPPVVALRTFGLNLTNKIGPVKNMIIDTLGGNEK
Protein: Outer membrane channel (Q8ZLZ4)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}.
Interaction partners:
- Acridine efflux pump
- Efflux pump membrane transporter
- Macrolide export ATP-binding/permease protein MacB
- Outer membrane porin C
- Outer membrane porin F
- Efflux pump membrane transporter
- Efflux pump membrane transporter
- Multidrug resistance protein MdtA
- Membrane protein
- Multiple antibiotic resistance protein MarA
Sequence:
MQMKKLLPILIGLSLSGFSTLSQAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGINSNETSASLQLTQTLFDMSKWRGLTLQEKAAGIQDVTYQTDQQTLILNTANAYFKVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEELRQVTGNYYPELASLNVEHFKTDKPKAVNALLKEAENRNLSLLQARLSQDLAREQIRQAQDGHLPTLNLTASTGISDTSYSGSKTNSTQYDDSNMGQNKIGLNFSLPLYQGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYDAKQQLANARYTYLINQLNIKYALGTLNEQDLLALNSTLGKPIPTSPESVAPETPDQDAAADGYNAHSAAPAVQPTAARANSNNGNPFRH
Protein: R2D2 (Q2Q0L3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNKSAVSALQEFCARTQINLPTYSFIPGEDGGYVCKVELLEIEALGNGRSKRDAKHLAASNILRKIQLLPGIHGLMKDSTVGDLGEELTNLNRDMVKELRDYCVRREMPLPSIEIVQQSGTPSAPEFVACCSVASIVRYGKSDKKKDARQRAAIEMLALISSNSDNLRPDQMQVASTSKLKVVDMEESMEELEALRRKKFTTYWELKEAGSVDHTGMRLCDRHNYFKNFYPTLKKEAIEAINSDEYESSKDKAMDVMSSLKITPKISEVESSSLVPLLSVELNCAFDVVLMGKETDIYDHIIDYFRTMLI
Protein: Tubulin-specific chaperone A (E5RIW3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU364030}.
Interaction partners:
Sequence:
MYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA
Protein: SRY-box containing protein 6 (SRY-box transcription factor 6) (F8W2H3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSKQATSPFTSTPDGGEDGVNQERMPWEKEENSESLVAPQLPLHNLLHNKPPLEELQPISSSVPPESDWDSLMSAQQRMESDSNKVCSLYSFRNNSTSPHKPEEGARERGDLLSSSAFGTPERRKGSLADVVDTLKQKKLEEMTKTEQDESSCMEKLLSKDWKEKMERLNTGELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQMEKQRQQMELARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGMSYKPGDNYPVQFIPSTMAAAAASGLNPLQLQQLYAAQLASMQVSPGAKMPPLPQPPNSAGQISPSGLKNEKRSSTPLAQVKEEGTQPLNLSARPKTAEPIKSPTSPTQSLFPGSKSSPNSLSKSGDIPSPIGGLGRGSSLDILSSLNSTALFGDQDAVMKAIQEARKMREQIQREQLQHHQQGMEVKLSALTSMGLNNCRTEKERSHYDNLGHHLSKLGEDGKIGHRVIDLTRPEDFEGGASTTEARVYREPRGRNSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMTNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIIDGKKLRISEYKQMMRSRRQEMRQFFTVGQQPQTQIPITTSAGVVYPGAITMATTTPSPHMTSDCSSASASPEPTIPVIQSTFNMKMEPGTMVPSDAVNGEDEMDMYEDFEDEPKSDYSSENDTHEPVSAN
Protein: POU class 2 homeobox 2 (U3KQ96)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPSTKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLSHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDA