wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein YLR283W, mitochondrial (Q05867)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative uncharacterized protein YLR125W
- Uncharacterized peptide chain release factor-like protein YLR281C
- MIOREX complex component 2
- Protein FYV6
- Elongation factor 1-beta
- J domain-containing protein 1
- Cytochrome c oxidase assembly protein COX16
Sequence:
MMRLIRTLPLRCFKTRIRRQGSLLCLRCFSSYSKPLLQKSMSLKNIQLSDLSSSPLSKNKEKQEKPEKENEGKHSIGLLDRFSEDFITQGNGLKPTTSQNQLDTIKFYQMLRERGNFSDEQCKIIIALLLQLLNDQFYSCYNDLFLRDMELNKQSHLFSSLETELKFAIQNSRDTQLNEHHLQLLKLKRELNSIHDELNEIIIDLLQKDAKLEFNNQKLENTLLYRQLNLKLNDCSNKIQTKILGDIRSHIENLRWQTTRSGLLVILVLVCSIMIGVSASKKERPGLQEPEEPEILAPKEDIDTTFPQDQHDID
Protein: AT-hook motif nuclear-localized protein 3 (Q9SB31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity). Acts redundantly with AHL4 to regulate the formation of tissue boundary between the xylem and procambium in the root meristem.
Subcellular location: Nucleus {ECO:0000269|PubMed:23335615}.
Interaction partners:
Sequence:
MEEREGTNINNNITSSFGLKQQHEAAASDGGYSMDPPPRPENPNPFLVPPTTVPAAATVAAAVTENAATPFSLTMPTENTSAEQLKKKRGRPRKYNPDGTLVVTLSPMPISSSVPLTSEFPPRKRGRGRGKSNRWLKKSQMFQFDRSPVDTNLAGVGTADFVGANFTPHVLIVNAGEDVTMKIMTFSQQGSRAICILSANGPISNVTLRQSMTSGGTLTYEGRFEILSLTGSFMQNDSGGTRSRAGGMSVCLAGPDGRVFGGGLAGLFLAAGPVQVMVGTFIAGQEQSQLELAKERRLRFGAQPSSISFNISAEERKARFERLNKSVAIPAPTTSYTHVNTTNAVHSYYTNSVNHVKDPFSSIPVGGGGGGEVGEEEGEEDDDELEGEDEEFGGDSQSDNEIPS
Protein: Polyamine oxidase 4 (OsPAO4) (EC 1.5.3.-) (Q7XR46)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine. Substrate preference is spermine > thermospermine > norspermine. No activity detected when putrescine, spermidine or N(1)-acetylspermidine are used as substrates. Plays an important role in the regulation of polyamine intracellular concentration (Probable).
Subcellular location: Peroxisome {ECO:0000269|PubMed:21796433}.
Interaction partners:
- Aminopropyl transferase
- Spermidine synthase 1
- Amine oxidase
- Amine oxidase
- Amine oxidase
- N-carbamoylputrescine amidase
- Polyamine oxidase 3
- Polyamine oxidase 5
- Os02g0254700 protein
- Polyamine oxidase 1
Sequence:
MDPNSLKTGGLLLPTIERQCASPPSVIVIGGGISGVAAARALSNASFEVTVLESRDRVGGRVHTDYSFGCPIDMGASWLHGVCNENSLAPLIGYLGLKLYRTSGDNSVLYDHDLESYALFDKAGHQVSKETVAKVEETFERILDETVKVRDEQEHDMPLLQAISLVLERHPHLKLQGIDDQVLQWCVCRLEAWFAADADEISLKNWDQEHVLTGGHGLMVNGYYPIIQALAQGLDIRLNQRVTKIARQFNGVTVTTEDGTSYSADACIITVPLGVLKANIIKFEPELPSWKSSAIADLGVGIENKIAMHFDTVFWPNVEVLGMVGPTPKACGYFLNLHKATGNPVLVYMAAGRFAQEVEKLSDKEAVDLVMSHLKKMLPDATEPTKYLVSRWGSDPNSLGSYSCDLVGKPADVSARFAAPVENLYFAGEAASADHSGSVHGAYSSGIAAADECRKRILMQKGIPDLVQVKAYEEMAGVIAPLQICRT
Protein: GH17761p (Ubiquitin-5E, isoform A) (Ubiquitin-5E, isoform B) (Q9W418)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- E1 ubiquitin-activating enzyme
- Ubiquitin-conjugating enzyme E2-17 kDa
- Ubiquitin-ribosomal protein eL40 fusion protein
- ubiquitinyl hydrolase 1
- Ubiquitin carboxyl-terminal hydrolase
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 4
- Ubiquitin-conjugating enzyme E2-22 kDa
- Ubiquitin carboxyl-terminal hydrolase 7
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAI
Protein: Histone acetyltransferase (EC 2.3.1.48) (Q7YTZ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361211}.
Interaction partners:
Sequence:
MRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNTNLKTLSPEQREFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERIEDELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPQDRRLLLKMAALHQYPAELISITTWLEACQGMLCRRRRR
Protein: Btbd2 protein (Q7TNF6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
AHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKHLRADNAFMLLTQARLFDEPQLASLCLESIDKNTADAIAAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENKRKVLGKALSLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT
Protein: Low affinity immunoglobulin gamma Fc region receptor III (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII) (CD antigen CD16) (P27645)
Organism: Rattus norvegicus (Rat)
Function: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b (By similarity). Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P08508}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- CD19 molecule
- High affinity immunoglobulin epsilon receptor subunit gamma
- Integrin alpha-D
- Neural cell adhesion molecule 1
- Receptor-type tyrosine-protein phosphatase C
- T-cell surface glycoprotein CD4
- Natural cytotoxicity triggering receptor 1
- T-lymphocyte activation antigen CD86
- NKG2-D type II integral membrane protein
- Interferon gamma
Sequence:
MTLETQMFQNAHSGSQWLLPPLTMLLLFAFADRQTANLPKAVVKRDPPWIQVLKEDTVTLTCEGTHNPGNSSTQWFHNQSSTWGQVQASYTFKATVNDSGEYRCRMAHTSLSDPVHLEVISDWLLLQTPQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYYQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQGSATASTSSLVWFHAAFCLVMCLLFAVDTGLYFCVRRNLQTSGEDWRKSLSVGKYKAPQDK
Protein: GTF2I repeat domain containing 2B (A0A494C1N8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAPKHKSSDAGNLDRPKRSRKVLPLSEKVKVLDLIRKDKKSYAEVAKIYGKNESSIREIVKKEKEIRASFAVSPPTAKVTATVRDKCLVKMEQALHLWVEEMNRKRVPIDSNMLRQKALSLYQDFCKGCSETDTKPFTASKGWLHRFRHRFSHHYKKKKKGIMAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNGEYSTVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYTERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFLRVEKSLKKFCINWSRLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLVSRNESDGLNYIPKIAELKTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT
Protein: Lipoprotein 28 (P04846)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Lipid-anchor.
Interaction partners:
- D-methionine transport system permease protein MetI
- Methionine import ATP-binding protein MetN
- D-methionine-binding lipoprotein MetQ
- Adenylyl-sulfate kinase
- Sulfate adenylyltransferase subunit 2
- Sulfate adenylyltransferase subunit 1
- Sulfate-binding protein
Sequence:
MKLTTHHLRTGAALLLAGILLAGCDQSSSDAKHIKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTALDITDNPRHLQIMELEGAQLPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEVAKAAETIFNGGAVPGW
Protein: Glutamate mutase epsilon subunit (EC 5.4.99.1) (Glutamate mutase E chain) (Glutamate mutase large subunit) (Methylaspartate mutase) (P80077)
Organism: Clostridium cochlearium
Function: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Interaction partners:
- Glutamate mutase sigma subunit
- methylaspartate ammonia-lyase
- Conserved hypothetical protein.
- L-glutaminase
- GntR family transcriptional regulator
Sequence:
MELKNKKWTDEEFHKQREEVLQQWPTGKEVDLQEAVDYLKKIPAEKNFAEKLVLAKKKGITMAQPRAGVALLDEHIELLRYLQDEGGADFLPSTIDAYTRQNRYDECENGIKESEKAGRSLLNGFPGVNYGVKGCRKVLEAVNLPLQARHGTPDSRLLAEIIHAGGWTSNEGGGISYNVPYAKNVTIEKSLLDWQYCDRLVGFYEEQGVHINREPFGPLTGTLVPPSMSNAVGITEALLAAEQGVKNITVGYGECGNMIQDIAALRCLEEQTNEYLKAYGYNDVFVTTVFHQWMGGFPQDESKAFGVIVTATTIAALAGATKVIVKTPHEAIGIPTKEANAAGIKATKMALNMLEGQRMPMSKELETEMAVIKAETKCILDKMFELGKGDLAIGTVKAFETGVMDIPFGPSKYNAGKMMPVRDNLGCVRYLEFGNVPFTEEIKNYNRERLQERAKFEGRDVSFQMVIDDIFAVGKGRLIGRPE
Protein: UBX domain-containing protein 3 (Q12229)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control. Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DSC E3 ubiquitin ligase complex subunit 2
- Transmembrane E3 ubiquitin-protein ligase 1
- Vacuole localized DSC protein 1
- Golgi/endosome-localized DSC protein 1
- Cell division control protein 48
- DSC E3 ubiquitin ligase complex subunit 3
- UBX domain-containing protein 5
- Ubiquitin fusion degradation protein 1
- Nuclear protein localization protein 4
- UBX domain-containing protein 7
Sequence:
MDIFRHTFGNNDDSFIRIPGAFREEPPADLNGRTEDQNSNTNEPTQSRDGRLKSILHFLFQAPLIVLYYLLNFIVRSSRLLKPLLRLHGFYQRKHNRLLDHSSQLHRLLENLENEAQAVTCSEGNGNNDDGSNTDSTSNNESSGVQFSFGSLYNPENGTFSKSIMQNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKYQVLLWYGDVTTSEGLQVSNALKIRQYPLLGIISLKAEKKIELIARVEGSISNYKAQDLEAIFSKNYSRLIQLRQQRQNIEMQRLIRQQQDSRYQDSLRRDQQRESERLEQTQREQMEREHQRIENQWLLWRKSQLKPEPSSDKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDMLNSENDTLPVYQPANYQHQYSFKLITPVPRRELDLSTKISDVSGIYPSGNIVMERLDE
Protein: Par-1, isoform W (EC 2.7.11.-, EC 2.7.11.26) (Ser/Thr protein kinase PAR-1alpha) (Q963E6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTAMRTTLQSVPEALPADSVSNGTASNVAAPAAPVSSATNAVPPLAAVSSTTATYATNSISTSSHSVKDQQQQQQQQQHDSANANIVSLPPTTTPVANTNTMMPIVTSSNSATSNSTAATPTPASGAAATGGVGSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGAETLRVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETKMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPNQ
Protein: Serine/threonine-protein kinase (EC 2.7.11.13) (D4A229)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000552}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Serine/threonine-protein kinase D1
- Serine/threonine-protein kinase D2
- Integrin beta-1
- Protein kinase C beta type
- Integrin subunit alpha L
- Protein kinase C gamma type
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Integrin beta
- A-kinase anchor protein 13
Sequence:
MSANNSPPSAQKSVFPATVSAVLPTPSPCSSPKTGLSARLSNGSFSAASLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHNMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPECVPLLSEESHTHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGLQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSVGTDTDMPMDIDSNDVNSDGSRGLDDSEEPSPPEDKMFFLDAADLDVERDEEPVKTISPSTSNNIPLMRVVQSIKHTKRKSSTVVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPQDFTSISQGSNPHCFEIITDTVVYFVGENNGNSTHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLATSISVSNCQIQENVDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLEYPKHFIMAPNPDDMEEGP
Protein: Zinc finger protein PLAGL1 (Lost on transformation 1) (LOT-1) (Pleiomorphic adenoma-like protein 1) (Tumor suppressor ZAC) (Q9UM63)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
Subcellular location: Nucleus {ECO:0000269|PubMed:11313869, ECO:0000269|PubMed:18299245}.
Interaction partners:
- Mesoderm-specific transcript homolog protein
- Cellular tumor antigen p53
- Paternally-expressed gene 3 protein
- Growth factor receptor-bound protein 10
- Protein delta homolog 1
- Pituitary adenylate cyclase-activating polypeptide
- Retrotransposon-derived protein PEG10
- DNA-binding protein RFX6
- Cyclin-dependent kinase inhibitor 1C
- Neuronatin
Sequence:
MATFPCQLCGKTFLTLEKFTIHNYSHSRERPYKCVQPDCGKAFVSRYKLMRHMATHSPQKSHQCAHCEKTFNRKDHLKNHLQTHDPNKMAFGCEECGKKYNTMLGYKRHLALHAASSGDLTCGVCALELGSTEVLLDHLKAHAEEKPPSGTKEKKHQCDHCERCFYTRKDVRRHLVVHTGCKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMKESLQTGDLLSTFHTISPSFQLKAAALPPFPLGASAQNGLASSLPAEVHSLTLSPPEQAAQPMQPLPESLASLHPSVSPGSPPPPLPNHKYNTTSTSYSPLASLPLKADTKGFCNISLFEDLPLQEPQSPQKLNPGFDLAKGNAGKVNLPKELPADAVNLTIPASLDLSPLLGFWQLPPPATQNTFGNSTLALGPGESLPHRLSCLGQQQQEPPLAMGTVSLGQLPLPPIPHVFSAGTGSAILPHFHHAFR
Protein: USH1 protein network component harmonin (A0A8I5Y9F7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPNRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPEEPLKWQYVDQFVSESGGVRGGLSSPGNRTTKEKKVFISLVGSRGLGCSISSGPIQKPGIFVSNVKPGSLSAEVGLETGDQIVEVNGIDFTNLDHKEGRELFMTDRERLEEARQHELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQISEEEEKFKKQWEEDWGSKEQLILPKTITAEVHPVPLRKPKYDQGVEPADHLDGSTKKQRQQDFRKYEEGFDPYSMFSPEQIAGKDVRLLRIKKEGSLDLALEGGVDSPVGKVVVSAVYEGGAAERHGGVVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
Protein: Leucine zipper protein 4 (Cancer/testis antigen 28) (CT-28) (CT28) (Tumor antigen HOM-TES-85) (Q9P127)
Organism: Homo sapiens (Human)
Function: Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters.
Subcellular location: Nucleus {ECO:0000269|PubMed:12032826, ECO:0000269|PubMed:25662211}. Cytoplasm {ECO:0000269|PubMed:25662211}. Note=In nuclear speckles. Relocalizes to the cytoplasm during cell division. {ECO:0000269|PubMed:12032826, ECO:0000269|PubMed:25662211}.
Interaction partners:
- Spliceosome RNA helicase DDX39B
- Nuclear RNA export factor 1
- Chromatin target of PRMT1 protein
- Serine/arginine-rich splicing factor 2
- UAP56-interacting factor
- THO complex subunit 5
- THO complex subunit 2
- THO complex subunit 1
- THO complex subunit 4
Sequence:
MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDDIIIYKELEGTNAEEEKNKRQNHSKKESPSRQQSKAHRHRHRRGYSRCRSNSEEGNHDKKPSQKPSGFKSGQHPLNGQPLIEQEKCSDNYEAQAEKNQGQSEGNQHQSEGNPDKSEESQGQPEENHHSERSRNHLERSLSQSDRSQGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQGDLVDTQSDLIATQRDLIATQKDLIATQRDLIATQRDLIVTQRDLVATERDLINQSGRSHGQSERHQRYSTGKNTITT
Protein: Uncharacterized protein YBR090C (P38253)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MVPAPGSRAFPSPVFLGGVFFVFFFRWRGNYKVQQVRLRQYWEFTLWETAPNTKQKNDFFAKTLTYIKLALWPQLKKQSNQRNQRRGPPGERRILTPLRGACQLICSLLMKTETLSVPRILT
Protein: Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) (O07417)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Mce-family protein Mce1A
- Conserved integral membrane protein YrbE1A
- Mce-family protein Mce1D
- Mce-family protein Mce1B
- Mce-family protein Mce1F
- Conserved integral membrane protein YrbE1B
- Mce-family protein Mce1C
- Probable ribonucleotide transport ATP-binding protein mkl
- Conserved integral membrane protein YrbE4B. Possible ABC transporter
- Conserved integral membrane protein YrbE4A. Possible ABC transporter
Sequence:
MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC
Protein: Rifin (Q8I2C1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKDHYINILLFALPLNILVYNQRNYYITPRHTETNRSLCECELYSPTNYDSDPEMKRVMQQFVDRTTQRFHEYDERMKTTRQKCREQCDKEIQKIILKDKIEKELAQQLTTLETNITTKDIPTCVCEKSLADKVEKTCLKCGGVLGGGIAPSVGILGGIGEAIMSAWKVAALKAATEYALTEGAAKGAIAGNAQGMEVVINFLKYWGVNEFFSEIFESILKISHYSKVKDFADAIITKKAQICADGLLKNPAMCRKIDIKFGLSDEYGTPIAGPPNIEIPQKISGLVEQADQAAVEVAKDTSQSVAAKITEEQTAVINATYTSWQIAITASVIAIVVIVLIMVIIYLILRYRRKKKMKKKLQYIKLLEE
Protein: Nuclear pore complex protein Nup93-1 (Nucleoporin 93kD-1) (Nucleoporin Nup93-1) (Q9XZ06)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for nuclear pore complex assembly, maintenance and function. Required for nuclear import of phosphorylated Mad via importin msk. Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta. Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets. Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells.
Subcellular location: Nucleus membrane {ECO:0000250|UniProtKB:Q8N1F7}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:31784359}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31784359}. Note=When not in the nuclear pore complex, can localize to the nuclear lumen proximal to the inner nuclear membrane. {ECO:0000269|PubMed:31784359}.
Interaction partners:
- Nuclear pore complex protein Nup205
- Nucleoporin Nup188
- Nuclear pore complex protein Nup154
- Nuclear pore complex protein Nup107
- Probable nucleoporin Nup54
- Nuclear pore complex protein Nup58
- Nucleoporin Nup35
- Nucleoporin seh1
- Nuclear pore complex protein Nup214
- Nuclear pore glycoprotein p62
Sequence:
MDLMELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDLPKLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEWGEEKEALLNALVGPNQQDFPDVQFQIVPTAMADEPTPYSQLNGHEQMYAEQIAIHNQSIILGRRPNLLSTLAHVVQDSFNDESVAEMWNVLQFMTALPPVSSTIDPIKNRQTSPQFVEQARTYLERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSLRSGDMDAAALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKAVYVVLLACDPHFTHVELMRSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEMLELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALRLVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEGALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILMH
Protein: KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Q8BX02)
Organism: Mus musculus (Mouse)
Function: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q63ZY3}. Mitochondrion {ECO:0000250|UniProtKB:Q63ZY3}.
Interaction partners:
- Kinesin-like protein KIF21A
- Rho GDP-dissociation inhibitor 1
Sequence:
MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCPLPTATTGNVHTAKKISITERSCTGAPRMTEPSSVNPRPAAASVVQPENPVPAAQDTTDKKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQRNLQFVGVNGGYESPSEDSSTAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVPAPEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE