wanglab/gogpt-training-data huggingface dataset:
Protein: Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) (P42568)
Organism: Homo sapiens (Human)
Function: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones. Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness. Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376, ECO:0000269|PubMed:27105114}. Chromosome {ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114}. Note=Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114). Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). {ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114}.
Interaction partners:
- AF4/FMR2 family member 1
- RNA polymerase II elongation factor ELL2
- RNA polymerase II elongation factor ELL
- AF4/FMR2 family member 4
- Protein ENL
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Cyclin-T1
- RNA polymerase II elongation factor ELL3
- Protein AF-10
- Cyclin-dependent kinase 9
Sequence:
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
Protein: Elongator complex protein 2 (ELP2) (STAT3-interacting protein 1) (StIP1) (Q91WG4)
Organism: Mus musculus (Mouse)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator comple catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6IA86}. Nucleus {ECO:0000250|UniProtKB:Q6IA86}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 3
- Elongator complex protein 5
- Elongator complex protein 4
- Elongator complex protein 6
- RNA polymerase-associated protein RTF1 homolog
- FACT complex subunit SSRP1
- RNA polymerase-associated protein CTR9 homolog
- RNA polymerase-associated protein LEO1
- Transcription elongation factor SPT5
Sequence:
MVSSVLEVSHVFCCPNRVRGALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWIRTEDGSPSNELVSGGSDNRVIHWELENNQVLKSVRLQGHEGPVCAVHAIYQSGPSEGEQHALIASAASDSTVRIWSKKGSEVKYLQTLSFRDGFVLSVCLAILPGTNVPVLACGDDDCRIHLYIQQDDQFQKALSLCGHEDWIRGVEWATFGRDLFLASCSQDCLIRIWRLYMKPASFETKDGSLRLKENTFTIKDGGVRTTVAVTLETVLAGHENWVNAVHWQPSFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFAPWKKKDQKDRSQVTWHEIARPQIHGYNIKCLAMIDRFQFVSGADEKVLRVFSAPRNFVENFSVISRQSLSHMLCDDQDLPEGATVPALGLSNKALFQGDIASQPFEEDELISPAFGSPQVTFQPAVLNEPPTEDHLLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACKASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATSSEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVWGECKSSHNPMEHPIRPCSSILDVGSSVTAVSVCPVLNPAQRYIVAIGLESGKICIYSWNKTNQEINDWTSCVETNPSQSHSLGIRRLCWKSCSDDDDDDDDDDTEQSEEGPEWLHFASCGEDHTVKIYRVNRRAL
Protein: Histone H2A (P02264)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome. Note=A secreted form has been detected in skin secretions.
Interaction partners:
Sequence:
MSGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTEKAVKAK
Protein: Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) (Tyrosine hydroxylase) (A0A060X6Z0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Plays an important role in the physiology of adrenergic neurons.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Note=Expressed in dopaminergic axons and axon terminals. {ECO:0000250|UniProtKB:P24529}.
Interaction partners:
- 4a-hydroxytetrahydrobiopterin dehydratase
- Pterin-4-alpha-carbinolamine dehydratase
- Uncharacterized protein
- Aromatic-L-amino-acid decarboxylase
- Histidine decarboxylase
- Aromatic-L-amino-acid decarboxylase
- aspartate transaminase
- Uncharacterized protein
- aspartate transaminase
- Aspartate aminotransferase
Sequence:
MPISSSSSSSTKSMRRAASELERSDSVTSPRFIGRRQSLIEDARKEREAAAAAAEAAEATEQIVFEEEDGKALLNLFFTLRSSKTPALSRSLKVFETFEAKIHHLETRPCRKPRDSLEGLEYFVRCEVHLSDVSTLISSIKRIAEDVKTTKEVKFHWFPKKISELDRCHHLITKFDPDLDQEHPGFTDPVYRQRRKMIGDIAFRYKQGEPIPRVEYTEEEIGTWREVYSTLRDLYTTHACSEHLEAFNLLERHCGYSPENIPQLEDVSRFLRERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCVHELLGHVPILADRVFAQFSQNIGLASLGASEEDIEKLSTLYWFTVEFGLCKQGGIVKAYGAGLLSSYGELVHALSDEPERREFDPEAAAIQPYQDQNYQSVYFVSESFTDAKEKLRSYVAGIKRPFSVRFDPYTYSIEVLDNPLKIRGGLESVKDELKMLTDALNVLA
Protein: FAM136A-like protein (DUF842) (A0ME58)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDHIAAAEEQIVTERIRRKLEEVNATAQSQLSPIQDHINFTLQQAYFKCAYECFDRNRKQEEIANCVEHCSVPVVNAQQHFEGEMSQFQERMNRSLMVCQDKFEAAKLHKNRGDAAKAMESCVNTSIEDSLDTLPHIVQRMKTSFSIADG
Protein: Nuclear rim protein 1 (Q12066)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Inner nuclear membrane protein SRC1
- Monopolin complex subunit LRS4
- Monopolin complex subunit CSM1
- Topoisomerase 1-associated factor 2
- Peflin
- Nucleolar protein NET1
- Tyrosine-protein phosphatase CDC14
- NAD-dependent histone deacetylase SIR2
- DNA replication fork-blocking protein FOB1
Sequence:
MGSNDLINEAYDDSEVVGEERESKSAWMKRWYQLLTSPLDLQLVINEKLEMINWDAYAKSLAKPLGNFLTILFFIIRLLQDNLIKPNYYKLNVKSGAFDLSKSNKLKEFDYLWEISSSFQNNNQFYAFQSWYFVTLRFLNNLFRFTIFILLSLNLYVSCKFMFGYFKTYNLFHLKKEFNSPNLTKHNLKDLSKEYYEDIYKQSLWSMLKHFFRGSRDDGPHVNQNEDEIFFQLRKWIPTNFMINLFVSFSPTAIVFLSFSDVSFTSAIAIVFHQYILDYIITKRFQRSVDDDLILSSAALQEYEDKHIMARINQCSNIDTLSSAMGTRSKTPRIFTTHSLCGEEIREVYNYEKREFEALPKMTESVPGSRETRIKDYGGISQVSDHQSHPIGFHYSPRMSPYYRDKVLDNNLAQSSSNENLEKGGAYLPNQDQNRPSKSLSPLRKTPLSARQKRFEGSEFNVLNKNDINSILRSPKKKKNYHKR
Protein: Translation initiation factor rli1 (ATP-binding cassette sub-family E member rli1) (RNase L inhibitor) (O60102)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Interaction partners:
- Eukaryotic peptide chain release factor subunit 1
- Probable eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit C
- Protein dom34
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit A
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS3
- Probable eukaryotic translation initiation factor 5
Sequence:
MSESLTRIAIVSEDKCRPKKCRQECRRSCPVVRTGKLCIEVNPTDRIAFISETLCIGCGICVKKCPFGAINIINLPTNLESEVTHRYSANSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILSGKMKPNLGRYDNPPDWAEVVKYFRGSELQNFFTKVVEDNIKALIKPQYVDHIPRAIKTGDKTVSGLIKARANNNNFEEVMDHTDLQNLLNREVGHLSGGELQRFAIAAVATQKADVYMFDEPSSYLDIKQRLKAGRVIRSLLATTNYVIVVEHDLSVLDYLSDFVCVLYGVPSMYGVVTLPYSVREGINIFLDGHIPTENLRFRSEALTFRLADASDEITADRTAEYNYPDHVIEQGDFKLTIKSGGFSDAEIIVLLGENGTGKTTFCKWMAKNSDLKISMKPQTIAPKFQGTVRMLFLKKIRAAFLNGKFQSEVCKPLSIDNIIDQEVLNLSGGELQRVAICLALGMPADVYLIDEPSAYLDSEQRIIASKVIRRFIVNSRKTAFIVEHDFIMATYLADRVILFEGQPSRDARCNPPQSLLTGMNTFLKNLDVTFRRDPNTLRPRINKFDSQMDQEQKNAGNYFFLEN
Protein: SLAM family member 9 (CD2 family member 10) (CD2F-10) (CD84 homolog 1) (CD84-H1) (Q96A28)
Organism: Homo sapiens (Human)
Function: May play a role in the immune response.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- T-cell surface antigen CD2
- SLAM family member 8
Sequence:
MCAFPWLLLLLLLQEGSQRRLWRWCGSEEVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPATIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLYQAQVNLRTSQISTMQQYNICVYRWLSEPQITVNFESSGEGACSMSLVCSVEKAGMDMTYSWLSRGDSTYTFHEGPVLSTSWRPGDSALSYTCRANNPISNVSSCPIPDGPFYADPNYASEKPSTAFCLLAKGLLIFLLLVILAMGLWVIRVQKRHKMPRMKKLMRNRMKLRKEAKPGSSPA
Protein: Transcription factor NDT80 (Q5ACU9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000305|PubMed:19542309}.
Interaction partners:
- NDT80 domain-containing protein
- Protein kinase
- Biofilm and cell wall regulator 1
- Enhanced filamentous growth protein 1
- Transcription factor ROB1
- Transcription activator TEC1
- Biofilm regulator 1
- Transcriptional regulator of filamentous growth FLO8
- Hyphal wall protein 1
Sequence:
MHPSAGVNNNQHLNHQPYQQMSHYNAQQMHQQQLHHQLMTPNPYQQHFQQQMHPQLHHEDHLNMHFNPMSYPQQQQQQQQQQQQQQQHLHHFGHQIPAPPAQQGPTPQQPHLHQQIPHPLSHHQTPQPTPQPLAQQQSPQPARQPRQTKKQKQQAQNQDQADAQSQAQQHHMAMMARANQNDMLESSTRKVAPRSSDLFRVGPPFSISKQHQPVYCVGTDMPVTPLLHARIDRGFEMGETGSWIGYKRNYFTLVASFTLQDFDFEKFIGNKFYTYDKVNNKVNGFPPHHPSHPQNQPQNHPGHPHHNQHAGESRVPISYFAIRLVAKCSDEDVAISLIQHTAKRDKGPQFPPPIYPAVPSELPDHETVKVSCNKRNNNKIETMNKIFYFDRGNYYQEYNLDSYKDQSILKSYPSQSISKVARFERIQFTSSIRVKSTNTTARYFTLHVELLGIIEDEDLQIQPILLSSIESPPLIVRGRSPSSYHKDRTSGYRATNTPTPTPPQ
Protein: KCNQ potassium channel, isoform E (Potassium channel KCNQ) (Q5PXF9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLDEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKAKDVYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDIGVEVDVDADADGDCDESTEDTALLQCATRTAIVITPISPVSSAHNLQQLNDQTTTLNKSNLLPPDSG
Protein: Band 4.1-like protein 3a isoform 1 (Erythrocyte membrane protein band 4.1-like 3a) (Zgc:92004) (Q68EI5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Spectrin beta chain
- Dehydrogenase/reductase
- Spectrin alpha, non-erythrocytic 1.
- Tetraspanin
- Ninjurin-2
- Myelin basic protein
- Tetraspanin
Sequence:
MTTEPEGKAEQQGACAAPPHSAPPLDNQLPPAAAHSTPVKKDQAGEREVGGVPQGKPNQLSAEDDGSSHWSSSSKLNRSPAKISKKPKNMQCKITLLDGSDYTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITFRDVENQKNWLDPAKDMKKQIRGVAWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPCSFATHTVLGSYTVQSELGDHDPEECGSEYTSEFRFAPQQTKEMEEKIIDLHKNYKGMTPAEAEMHFLENVKKLSMYGVDLHHAKDSEGVEIMLGVCSSGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPETPPKKFLTLGSKFRYSGRTQAQTRRASSQIVRPAPYFQRSSSKRYTMSRSLDGEMGTALYGAAKGIAMSDLITTVTPEKKVEEEPQPQKHTHADKQMQPQTETETETDTHTQTQTVLVENVMILEDDDETTRATELSLPSPATPARLDTRTDLTDTAVDGELTATESDQEDESEAKTKEADLTPDEQLKPQTNISELKRTFLEGGAEPAGLTEWEKRLSSSPLRSPRREEPPMIEPLELDEIKQEVVVETQEVAETQEVAAALDTQENNRKVDEPKPSFEEMSPELTALLQSARSWTPVPASASPSASASALVTPAPAALHTPQNQPSESVDEHLGKGLTEEERPADEPLDKPQTGVLSFRSVSGDTHDTHETHDTPVIQTEIKTITYEALQAETDGDADPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVISGDADIDHDED
Protein: Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] (P06883)
Organism: Rattus norvegicus (Rat)
Function: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01275}.; SUBCELLULAR LOCATION: [Glucagon-like peptide 1]: Secreted {ECO:0000250|UniProtKB:P01275}.
Interaction partners:
- Glucagon-like peptide 1 receptor
- Glucagon receptor
- Gastric inhibitory polypeptide receptor
- Glucagon-like peptide 2 receptor
- Dipeptidyl peptidase 4
- Appetite-regulating hormone
- Glucose-dependent insulinotropic receptor
- Leptin
- Vasoactive intestinal polypeptide receptor 2
- Somatostatin
Sequence:
MKTVYIVAGLFVMLVQGSWQHAPQDTEENARSFPASQTEPLEDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIAEELGRRHADGSFSDEMNTILDNLATRDFINWLIQTKITDKK
Protein: SMP-LTD domain-containing protein (Q54MI5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
- SMP-LTD domain-containing protein
- Bacterial surface antigen
- Translocase of outer mitochondrial membrane
- Probable mitochondrial Rho GTPase gemA
- Uncharacterized transmembrane protein DDB_G0283573
- Translocase of outer mitochondrial membrane
- Glutathione S-transferase domain-containing protein
- Mitofilin
- Uncharacterized protein
- Reticulon-like protein
Sequence:
MYTLLVGFLLGIIFSSVILIYTFFQLLSKKVDPKDIPVRKQQISKTTTTTTTTTTTTTSIHPKDITTDKLQEILDFSDIRPTSIETCKWINFIAARILSDLNNSSQFSQKIYSFLNNIFDENNKPDFLGKLNFSDISFGSTTPEIGIVKLVSPPNSSYSILEFDIIYSGDASVTASSELWLNWPQKHIACLPVKTKLSLKHFSGKFVLYIPNTPNPTCVVYLKNAPQIQLRMITKMGHETVLKEPGKIGTFLQTQIIKHINQRLVPPNFLSFNIFQFLYNTPLKVNHNIHTINPIIQNNSNNNNNNNNNENNNTIYNTSPITSPIPSPPLQSSLKSTNSPNGVKKRSTNKVSYSPINSK
Protein: Rothein 3.3 (P86513)
Organism: Litoria rothii (Roth's tree frog) (Hyla rothii)
Function: Lacks antimicrobial activity. Does not inhibit the formation of NO by neuronal nitric oxide.
Subcellular location: Secreted {ECO:0000269|PubMed:16124032}.
Interaction partners:
Sequence:
ASAAGAVRAGDDETLLNPVLNSLDNLVSGL
Protein: Peptide receptor GPCR (Q7YTE8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTMSSTSTATATSTATATLDEANATVGEMFSDADMAEVRHVVQRILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYWQLYGYFVWLCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITIGTRQIDDAYQPCNQTVANISPMPPSPVAVTPPLATPPLPTPATIWQSPDSAMESTTSGSSNQLVDWGSGSGDGEPENIPRHRRHWQSSGFVTLPTLRKTLEEQDQEVADAGQGSGVTESLLQLWRRKRSAENHNINNTDAFAFNVTEYCQNVTYYNHGLSELGYDELYSYLWNLFTLLVFVVFPLLLLATFNSILILLVHRSKNLRGDLTNASSIRRTKRKSNSGLKGSVSQENRVTITLIAVVLMFIVCQLPWAIYLIVNQYMEIQIGTQVVAGNVCNLLASLHAASNFFLYCVLSDKYRKTVRELITGYRYRRRHARNNTSLYVPHTTTTLTQINGDHYGSNYGGAGSRRNRNTGRLIA
Protein: XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form] (Q5GH76)
Organism: Homo sapiens (Human)
Function: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5GH67}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- DGAT1/2-independent enzyme synthesizing storage lipids
Sequence:
MAAKSDGRLKMKKSSDVAFTPLQNSDHSGSVQGLAPGLPSGSGAEDEEAAGGGCCPDGGGCSRCCCCCAGSGGSAGSGGSGGVAGPGGGGAGSAALCLRLGREQRRYSLWDCLWILAAVAVYFADVGTDVWLAVDYYLRGQRWWFGLTLFFVVLGSLSVQVFSFRWFVHDFSTEDSATAAAASSCPQPGADCKTVVGGGSAAGEGEARPSTPQRQASNASKSNIAAANSGSNSSGATRASGKHRSASCSFCIWLLQSLIHILQLGQIWRYFHTIYLGIRSRQSGENDRWRFYWKMVYEYADVSMLHLLATFLESAPQLVLQLCIIVQTHSLQALQGFTAAASLVSLAWALASYQKALRDSRDDKKPISYMAVIIQFCWHFFTIAARVITFALFASVFQLYFGIFIVLHWCIMTFWIVHCETEFCITKWEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSALWYLYKAPQIADAFAIPALCVVFSSFLTGVVFMLMYYAFFHPNGPRFGQSPSCACEDPAAAFTLPPDVATSTLRSISNNRSVVSDRDQKFAERDGCVPVFQVRPTAPSTPSSRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAILAFECSPSPPRLQYKDDALIQERLEYETTL
Protein: K-box region and MADS-box transcription factor family protein (F4J705)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEEGGSSHDAESSKKLGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYANNSFIYLLLEKKKKKKKKKNLWIYSSHVVRGTIERYKKACSDAVNPPSVTEANTQYYQQEASKLRRQIRDIQNSNRHIVGESLGSLNFKELKNLEGRLEKGISRVRSKKNELLVAEIEYMQKREMELQHNNMYLRAKIAEGARLNPDQQESSVIQGTTVYESGVSSHDQSQHYNRNYIPVNLLEPNQQFSGQDQPPLQLV
Protein: Cytochrome c oxidase assembly factor 1 (O14320)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Protein mss51
- Uncharacterized membrane protein C757.15
- Cytochrome c oxidase subunit 1
Sequence:
MISSKSLDYTRFLPFFAALVRGHCLTVKSPTHNCGSGVKTIMDKSSIFLKNRYPISINRFVQQRKTFCGASVCLHKVLVQRQFGFEEKSHGLKYKKLFRRNIGTSEKKNRLPDLLELSSSPRRLPILFAAFCLLWGTCAVLAIQYGKQNSNVTQVVMYRVQHSKEAQDLLGSNIDFKYPFPWVPGKLHKRQGFIDINFEVSGSLASGTVHYQSQRFGPIAHWVELDCTLTSNGKTIKIPTGVSKDTQWT
Protein: ATP-dependent 6-phosphofructokinase 1 (ATP-PFK 1) (Phosphofructokinase 1) (EC 2.7.1.11) (Phosphohexokinase 1) (Q9M0F9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03186, ECO:0000269|PubMed:17485088}. Note=May be associated with the plasma membrane.
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
- Aldolase-type TIM barrel family protein
- transaldolase
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
- Hexokinase-3
- Hexokinase-4
- Hexokinase-1
Sequence:
MSSSVPNSDRKIVTGPAGYILEDVPHFSDDFPDHPTYPNPLQDNAAYSVVKQYFVDEDDTVPQKIVVHPDSPRGTHFRRAGPRQRVYFESDDVLACIVTCGGLCPGLNTVIREIVCGLSYMYGVKRILGIDGGYRGFYARNTIHLDLKTVNDIHRSGGTILGTSRGGHNTTKIVDSIQDRGINQVYIIGGDGSQKGAAAIFEEIRKRKLKVAVAGIPKTIDNDIPIIDRSFGFDTAVEEAQRAINAAHVEATSFENGIGLVKLMGRYSGFIAMHATLASRDVDCCLIPESPFFLEGSGGLFEFIDKRLKESGHMVIVIAEGAGQDLLSESMKESTTLKDASGNKLLQDIGLWISQRIKDHFAKKMTLTLKYIDPTYMIRAVPSNASDNVCCTLLAQSAVHGVMAGYNGFTVGLVNGRHTYIPFNRITEKQNKVVITDRMWARLLSSTNQPSFMKQADKIHSNQLVGEPGTMKW
Protein: Ferredoxin-1, chloroplastic (Ferredoxin I) (Fd I) (P00221)
Organism: Spinacia oleracea (Spinach)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MAATTTTMMGMATTFVPKPQAPPMMAALPSNTGRSLFGLKTGSRGGRMTMAAYKVTLVTPTGNVEFQCPDDVYILDAAEEEGIDLPYSCRAGSCSSCAGKLKTGSLNQDDQSFLDDDQIDEGWVLTCAAYPVSDVTIETHKEEELTA
Protein: S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) (P20443)
Organism: Mus musculus (Mouse)
Function: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
Subcellular location: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:16421323}. Membrane {ECO:0000269|PubMed:16421323}; Peripheral membrane protein {ECO:0000269|PubMed:16421323}. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes. {ECO:0000250|UniProtKB:P08168, ECO:0000250|UniProtKB:P10523}.
Interaction partners:
- Rhodopsin
- Beta-2 adrenergic receptor
- G protein-coupled receptor kinase 4
- Rhodopsin kinase GRK1
- Guanine nucleotide-binding protein G
- Recoverin
- D
- Mu-type opioid receptor
- Retinol-binding protein 3
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MAACGKTNKSHVIFKKVSRDKSVTIYLGKRDYVDHVSQVEPVDGVVLVDPELVKGKKVYVTLTCAFRYGQEDIDVMGLTFRRDLYFSRVQVYPPVGAMSVLTQLQESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVGKSCGVDFEVKAFASDITDPEEDKIPKKSSVRLLIRKVQHAPPEMGPQPSAEASWQFFMSDKPLNLSVSLSKEIYFHGEPIPVTVTVTNNTDKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQEKVQPNSTLTKTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVMGILVSYHIKVKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESVQDENLVFEEFARQNLKDTGENTEGKKDEDAGQDE