wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase T (PPT) (EC 3.1.3.16) (P53043)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90 (HSC82 and HSP82). Dephosphorylation positively regulates the Hsp90 chaperone machinery.
Subcellular location: Nucleus {ECO:0000269|PubMed:12694636, ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent molecular chaperone HSP82
- ATP-dependent molecular chaperone HSC82
- Co-chaperone protein SBA1
- Hsp90 co-chaperone Cdc37
- Mitochondrial holo-[acyl-carrier-protein] synthase
- Putative uncharacterized protein YJR018W
- Hsp90 co-chaperone HCH1
- Damage-control phosphatase YMR027W
- Hsp90 co-chaperone AHA1
Sequence:
MSTPTAADRAKALERKNEGNVFVKEKHFLKAIEKYTEAIDLDSTQSIYFSNRAFAHFKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDPAATKALLTCDRFIREERFRKAIGGAENEAKISLCQTLNLSSFDANADLANYEGPKLEFEQLYDDKNAFKGAKIKNMSQEFISKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVPGHGILQAGRNDDQNLIIETFEAVEHPDIKPMAYSNGGFGL
Protein: Sorting and assembly machinery component 50 homolog A (Q803G5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in the maintenance of the structure of mitochondrial cristae.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y512}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Coiled-coil-helix-coiled-coil-helix domain containing 3a isoform 1
- Metaxin-2
- Mitochondrial import receptor subunit TOM40 homolog)
- Mitochondrial import receptor subunit TOM22 homolog
- MICOS complex subunit MIC60
- Mitochondrial import receptor subunit TOM40B
- Metaxin.
- Metaxin-3
- Metaxin
- Membrane-bound transcription factor peptidase, site 2.
Sequence:
MGTVHARSLDPLPMQGPELGVQADDMDLGEPEREEKQEVLENKDVVVQHVHIDGLGRTKEDILTYEIADVFHAKNLIDVMKKSHEARQKLLRLGIFRHVEVVIDTAEGADALPNGLDVTFEVRELRRMTGSYNTMVGNNEGSMVLGIKLPNVLGRAEKLTFQFSYGTKETSYGLSFFKPQPGHFERNFSLNLYKVTGQFPWSSLRETDRGVSAEISFPIWRTSHTLKWEGVWRELGCLARTASFAVREESGHSLKSSLAHAMVIDTRNSTILPRKGALLKINQELAGYTGGDVSFLKEDFEIQLNKTLFWDSVLSTSLWGGMLLPLGEKASSIADRFYLGGPTSVRGFSMYSIGPQSEGDYLGGEAYWAGGVHLYTPLPFRPGRGGFGDLFRTHFFLNAGNLCNLNYGEGPRAHLSKLAECIRWSYGAGIVLRLGNIARLELNYCIPMGVQSGDRICDGVQFGAGIRFL
Protein: Uncharacterized protein (Q38DW6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 5'-deoxynucleotidase
- p-nitrophenylphosphatase, putative
Sequence:
MFSASWGGIARPTALLRRRFIPPWERDGKAADDFFAGLMQSSNPVITKKKMQSRHEEMERQALTEELSPSDMLRIEELHLRNEAVLRERRDFVPYGAKPVIYFDNNKMAAIGDYASRLKTHAAPSSGGGYSDDVLDMLKADLHQKIPYKFESSVERRGNELRWPLHGTAGIVLDVDGVVYRMRKIIEGSDVAIRKLMELKIPLLFMTNGGGVSEEKKAEEYSRLLGCTIDASQVLLAHTPMKLLAQMYKGQKVLIVGSLESANVAKAYGFDGAISIQRFQAEHPELVPFRRWGSLEKVSDVNVPFPEIAAVFVLREPEDAFCDIQTIIDVLLSPRGKVGKYVSSTQSIPLYCASDDFLWAAEAELPRLGNGAFREMLHAVFYSLTGQNLHVTTYGKPRAIAYAFAERRMKEVTSRLGWNPEDMRAIFMVGDNVDTDIMGANARGGKWTSVHVLSGVGVTPVAYRTKSENDTEFEWMEKNGDKTPHYVAPTLDHFARELLAFPENAMLQNKKKYYGMPNPVDLHEDYGFS
Protein: Insulin (A5PJB2)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MALWTRLAPLLALLALWAPAPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN
Protein: Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) (Q584S0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Nucleoside hydrolase, putative
- Inosine-adenosine-guanosine-nucleoside hydrolase
- Adenylate kinase, putative
- Adenylate kinase, putative
- Adenylate kinase, putative
- Adenylate kinase, putative
- Adenylate kinase, putative
Sequence:
MSSAPLRVYVQCNPLLDVSAHVSDEFLVKYGLERGTAILLSERQKGIFDDIEKMPNVRYVPGGSGLNVARVAQWMQQAYKGKFVTYVGCIADDRYGKVLKEAAEHEGIVMAVEHTTKAGSGACAVCITGKERTLVADLGAANHLSSEHMRSPAVVRAMDESRIFYFSGFTLTVDVNHVLQACRKAREVDGLFMINLSAPFIMQFFSAQLGEVLPYTDIIVANRHEAKEFANMMKWDTDCVEEIARRAVSEVPYTGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVIDMNGAGDAFMGGFLSAYAVGKDLRRCCETGHYTAQEVIQRDGCSFPEKPSFSP
Protein: Synaptogyrin-3 (Q8R191)
Organism: Mus musculus (Mouse)
Function: May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:14755516, ECO:0000269|PubMed:19357284}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000269|PubMed:14755516}. Note=Found at the neuromuscular synapses. {ECO:0000269|PubMed:14755516}.
Interaction partners:
- Synaptophysin
- Synaptotagmin-1
- Synaptic vesicle glycoprotein 2A
Sequence:
MEGASFGAGRAGAAFDPVSFARRPQTLLRVVSWVFSIAVFGPIVNEGYVNSDSGPELRCVFNGNAGACRFGVVLGLGAFIACVAFLLLDVRFQQISSVRDRRRAVLLDLGFSGVWSFLWFVGFCFLTNQWQRTTPGPGTAQAGDAARAAIAFSFFSILSWVALTVKALQRFRLGTDMSLFATDQLGTGAAQAYPGYPVGSGVEGTETYQSPPFTETLDTSSKGYQVPAY
Protein: Gene regulation protein (Q7SIF6)
Organism: Heliothis virescens (Tobacco budworm moth)
Interaction partners:
Sequence:
AAVQELSIERLLEMESLVADPSEEFQFLRVGPDSNVPPKFRAPVSSLCQIGNKQIAALVVWARDIPHFSQLEMEDQILLIKGSWNELLLFAIAWRSMEFLTEERDGVDGTGNRTTSPPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRTLRVDQAEYVALKAIILLNPDVKGLKNRQEVEVLREKMFLCLDEYCRRSRSSEEGRFAALLLRLPALRSISLKSFEHLFFFHLVADTSIAGYIRDALRNHAPPIDTNMM
Protein: GH01721p (Rau, isoform A) (Rau, isoform B) (Q9VML8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLKHVQISPLRNRSDSVSLRSSSHASSCASSMCGSPEPPAELQRTPSRASSYSSLNEQLPQTTIKVYTNCLKIDIEYKTLGIQWDTTSKEVIGQLLRRLKMRHRDPRLFYLSMEVAVRRAGVKTILVLDDDTRPAIMQACHPKGESRFCLQLKPGGLIRVHTSALQPSSQYKSLVISEETTCDELLHLLLGCYSSPEPVENFSLYEVCPGQECQRKLHPDDLPLRTQMERMKRGEGCHFLVRRTPNYARRRQLLANLNEAIGQAAEAAEDATSLLELSLESDLSLSEDLRSCSSSEDAEDEDECASSSGSSDNSTECALRRDFYVHTTPAAPAPVVPQVAVSVSPARVYSPVYNIREIRTASHSFSSLGKDKKLLDIHMNARFASGGVYGRLMPVAETETQDMNGNTSTKLTAEAVNNNPAKGLGHFVYL
Protein: Neuronal-specific septin-3 (Q9UH03)
Organism: Homo sapiens (Human)
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Synapse {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C17orf47
- Septin-5
- Septin-7
- Septin-2
- Septin-11
- Septin-6
- Septin-1
- Septin-9
- Septin-12
- Septin-8
Sequence:
MSKGLPETRTDAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE
Protein: Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) (Q9BZ95)
Organism: Homo sapiens (Human)
Function: Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Bromodomain-containing protein 4
- Bromodomain-containing protein 3
- Histone H3.1t
- Histone H3.2
- Histone H3.1
- Histone H3-7
- Histone H3.3
- Histone H3.3C
- Histone H4
- Bromodomain-containing protein 2
Sequence:
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE
Protein: Cytochrome P450 4A2 (CYPIVA2) (Cytochrome P-450 K-2) (Cytochrome P450 K-5) (Cytochrome P450-LA-omega 2) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (P20816)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase that catalyzes omega and omega-1 hydroxylation of saturated fatty acids. Exhibits preferential omega versus omega-1 regioselectivity and (R) versus (S) stereoselectivity for hydroxylation of lauric and myristic acids. Has low activity toward palmitic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 2E1
- Cytochrome P450 3A1
- Cytochrome P450 1A2
- Cytochrome P450 1A1
- Cytochrome P450, family 2, subfamily j, polypeptide 4
- UDP-glucuronosyltransferase 2B15
- UDP-glucuronosyltransferase 1A1
- Cytochrome P450 2U1
- Cytochrome P450 3A
- Cytochrome P450 3A18
Sequence:
MGFSVFSPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR
Protein: Sterol regulatory element-binding protein 1 (Sterol regulatory element-binding transcription factor 1) (A6XLD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNLSFDDTSLDTLDSSLSLHDPSDIDTALLNDIDDMLQLINTQDMEFGLFDQASFPAPAAPAQEQLHSSPASPAAAPPPAASSILSSSPHLDALLGPPITRSSSIPTDKAFQPHTFQQAPLAQVNSTPAALQTTQPKAQPAPSASLQPSSQTPPSASSSPQQTLYSSYTTHTTYTPVTQQSSPQSIPSLSASPQNIQPMTIQSVSASPILTASSSPPTQPLPPQVQQLPVLLQPQFIKADSLLLTTLKPDVTMVTTVASPCITTLTSTAPVQNTPLQALMSGGTILTTVPLVVDTEKLPINRIAISGKPGCQPHKGEKRTAHNAIEKRYRSSINDKIIELKDLVAGTEAKLNKSAVLKKAIEYIRYLQQSNQKLKQENMALKMNIQKNKSLKDLVTMEVDVKPEIPTPPASDVGSPQSSGPYSQHSSDSEPDSPMAEDSKAVVERAGGMLDRSRMALCAFTLLFLSFNPLASLLCGGWSSAGASVPGNAAGRSVLSLEDSGESWGWMDWMLPTLLVWLLNGVLVAGVLIRLQVYGEPMTRPHSESSVLFWGHRKPADLDLARGDFAQASQNLRTCLKALGRPLPPSQLDLACAVLWSALRLCLQRLWVGRWLASRAGALRPNRPLQEDNCKSCRDAALVYHRLHQLHMTGKLGGSHLSAIHMALSALNLAECAGDCLPVATLAEVYVSAALRVKTSLPRLLHFTTRVFLSSARQACLSPSGSVPPAMQWLCHPLGHRFFVDEDWTIRSSPRESIYSQAGNSVDPLAQVTQGFREHLLEKALYCVAQPRGDKSLADGDGEFSDALEYLQLLTSAADAAGATTQSFAIGSNMATVTGCDPHSKWWSSMVVVVTNWLQGEDAAAERLYPAVEHLPRSLQSAESPLPKACVNVFKAVRTLLAKPESQQPSLSYCERASVLFRDSLNLGPHCSASTQLDKLVQLLLCDLLLVTRTNVWRDQQVCSSSSTAAASPAELQGFQQDLSSLRRLAHSFRPATRRLFLHEATARLMAGASPTRTHQLLDRSLRRRATPGARIEECELHPGQREQAEAVMLACRFLPPSFLSAPGQRVGMLADAARTLEKLGDKRTLHDCQQMIIKLGSGTTVTST
Protein: Rhomboid protease AarA (EC 3.4.21.105) (Intramembrane serine protease) (P46116)
Organism: Providencia stuartii
Function: Rhomboid serine protease that catalyzes intramembrane proteolysis. Mediates quorum-sensing and the subsequent regulation of target genes via activation of the Tat protein export system. Catalyzes the proteolytic activation of TatA by removal of its N-terminal extension.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15616571, ECO:0000269|PubMed:17215357}; Multi-pass membrane protein {ECO:0000269|PubMed:15616571, ECO:0000269|PubMed:17215357}.
Interaction partners:
- Sec-independent protein translocase protein TatA
- Rhomboid family intramembrane serine protease GlpG
Sequence:
MAEQQNPFSIKSKARFSLGAIALTLTLVLLNIAVYFYQIVFASPLDSRESNLILFGANIYQLSLTGDWWRYPISMMLHSNGTHLAFNCLALFVIGIGCERAYGKFKLLAIYIISGIGAALFSAYWQYYEISNSDLWTDSTVYITIGVGASGAIMGIAAASVIYLIKVVINKPNPHPVIQRRQKYQLYNLIAMIALTLINGLQSGVDNAAHIGGAIIGALISIAYILVPHKLRVANLCITVIAASLLTMMIYLYSFSTNKHLLEEREFIYQEVYTELADANQ
Protein: Homeobox protein CDX-1 (Caudal-type homeobox protein 1) (Q05095)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
KTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQQQQQQPMPPTQLPLPLDGTPTPSGHPGSLCPTNAGLLGTPSPVPVKEEFLP
Protein: Metallophosphoesterase, isoform D (EC 3.1.3.-) (A0A0B4LG64)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASLRVVNRLVCRGFVALTLLLVFFNEFIVYYMAQSSWQPIDCKLDNCTRLLLIADPQILGNSYDRSSHSPLARYDSDRYLAKTFERALAFTQPHIIVFLGDLLDEGNIATAQEYKQYVQRFRRIYQNKNYKKFRMISAFFQRVHVPGDNDIGGENGDYISNSNQRRFENEFMSEDLFDYDNRLRFFKINRMLLDFSNPDRDNNADRLRIGVSHAPLLIGGGPLLRAIISDLDPHIIFSGHWHESRIFIYPSTKVINFYENSVRHFDLKALKEQEHSYLEIMVPTCSYRMGKSKIGLGYAVLENYNLSYTVLWQPNRFILLFTYVFWGLFVVCGFVVFKMMTRCPFRVAKRQTLYNRVSTIPQF
Protein: RE72930p (Q8IGK4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASELDQFADLELSKEDREQIFDPPLDRQQLEGAGTSRAAVGLNGVEFEGSKLHAEQLDKNQRRSQRNQRNPYPGMPGPGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRILEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAIAPQSLMFPGLHPMAMMSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQALPPQLHHQPVSSASSSSTPPAHHQQQASTAATSHQLQQQQPSPPPPGNATAAAAQQQQQLASSQQ
Protein: Elongation factor 1-beta (EF-1-beta) (O70251)
Organism: Mus musculus (Mouse)
Function: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
Interaction partners:
- Elongation factor 1-gamma
- Elongation factor 1-delta
- Small ribosomal subunit protein RACK1
- Translationally-controlled tumor protein
- Small ribosomal subunit protein uS3
- Elongation factor 1-alpha 1
- Small ribosomal subunit protein eS8
- Elongation factor 1-alpha 2
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL31
Sequence:
MGFGDLKTPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSGPPPADLCHALRWYNHIKSYEKEKASLPGVKKSLGKYGPSSVEDTTGSGAADAKDDDDIDLFGSDDEEESEEAKKLREERLAQYESKKAKKPAVVAKSSILLDVKPWDDETDMTKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI
Protein: Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (P55068)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q96GW7}.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase zeta
- Aggrecan core protein
- A disintegrin and metalloproteinase with thrombospondin motifs 4
- A disintegrin and metalloproteinase with thrombospondin motifs 5
- Neurocan core protein
- Agrin
- Neuronal cell adhesion molecule
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
- Decorin
- Versican core protein
Sequence:
MIPLLLSLLAALVLTQAPAALADDLKEDSSEDRAFRVRIGAAQLRGVLGGALAIPCHVHHLRPPPSRRAAPGFPRVKWTFLSGDREVEVLVARGLRVKVNEAYRFRVALPAYPASLTDVSLVLSELRPNDSGVYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFAGAQEACARIGARIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQNPREACYGDMDGYPGVRNYGVVGPDDLYDVYCYAEDLNGELFLGAPPGKLTWEEARDYCLERGAQIASTGQLYAAWNGGLDRCSPGWLADGSVRYPIITPSQRCGGGLPGVKTLFLFPNQTGFPSKQNRFNVYCFRDSAHPSAFSEASSPASDGLEAIVTVTEKLEELQLPQEAVESESRGAIYSIPITEDGGGGSSTPEDPAEAPRTPLESETQSVAPPTGSSEEEGEALEEEERFKDTETPKEEKEQENLWVWPTELSSPLPTGLETEHSLSQVSPPAQAVLQVGASPSPRPPRVHGPTVETLQPPGEGSLTSTPDGAREVGGETGSPELSGVPREREEAGSSSLEDGPSLLPETWAPVGTREVETPSEEKSGRTVLTGTSVQAQPVLPTDSASRGGVAVAPSSGDCIPSPCHNGGTCLEEKEGFRCLCVPGYGGDLCDVGLHFCSPGWEPFQGACYKHFSTRRSWEEAESQCRALGAHLTSICTPEEQDFVNDRYREYQWIGLNDRTIEGDFLWSDGPPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPQLPLAQIFGRPRLRYAVDTVLRYRCRDGLAQRNLPLIRCQENGLWEAPQISCVPRRPARALRSMTAPEGPRGQLPRQRKALLTPPSSL
Protein: Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) (Q8BKE9)
Organism: Mus musculus (Mouse)
Function: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). Essential for flagellogenesis during spermatogenesis.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:16775004}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q96LB3}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:31004481}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:31004481}. Note=In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails. {ECO:0000269|PubMed:31004481}.
Interaction partners:
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 25 homolog
- TRAF3-interacting protein 1
Sequence:
MASNHKSSAPRPISRGGIGLTGRPPSGIRPPSGNVRVATAMPPTTARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMSDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNMKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIEASIITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQLDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVLSTHRNAFKKIMEKLTSDYDTLKRQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATKSQESDYQPVIKNVMKQIAEYNKTIMDALHNASRS
Protein: RING finger protein 11 (Q9Y3C5)
Organism: Homo sapiens (Human)
Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Subcellular location: Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269|PubMed:16123141}.
Interaction partners:
- Tax1-binding protein 1
- E3 ubiquitin-protein ligase Itchy homolog
- E3 ubiquitin-protein ligase SMURF2
- Tumor necrosis factor alpha-induced protein 3
- Ubiquitin-conjugating enzyme E2 N
- STAM-binding protein
- Epidermal growth factor receptor substrate 15
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- Ubiquitin-conjugating enzyme E2 D1
- Signal transducing adapter molecule 2
Sequence:
MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN
Protein: Amino acid ABC transporter periplasmic binding protein (Q9I484)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Amino acid ABC transporter ATP binding protein
- Amino acid ABC transporter membrane protein
- Probable permease of ABC transporter
- Bifunctional trans-3-hydroxy-L-proline dehydratase/2-epimerase
- Arginine ABC transporter permease protein ArtM
- Amino acid APC family transporter
- Glutamate/aspartate import permease protein GltK
- Amino acid ABC transporter membrane protein
- Glutamate/aspartate import permease protein GltK
- Amino acid ABC transporter ATP binding protein
Sequence:
MNTKKTLALALTAALGCSLAGLAQADKLDDIIESGKLRCAVTLDFPPMGSRDAQNNPVGFDVDYCNDLAKALDVKAEIVETPFPDRIPALVSGRADVIVASTSDTLERAKTIGMSIPYFAFVKVVLTREDTGIASYEDLKGRPVGGTAGTFEALALEKDSKAWGDAKGSFRAYQSEADTALAISQGHIDATVVSSTVAASWIKSGKYKGLKIAGDAPYDIDYVALGAKRNEYGLLNYLNLFINQQVRTGRYAELAQKWVGGTAPELTTSAVYR
Protein: Riparin-5.1 (P86129)
Organism: Crinia riparia (Streambank froglet) (Flinders Ranges froglet)
Function: Has no antimicrobial activity. Does not inhibit the formation of NO by neuronal nitric oxide synthase.
Subcellular location: Secreted {ECO:0000269|PubMed:16470724}.
Interaction partners:
Sequence:
IVSYPDDAGEHAHKMG