wanglab/gogpt-training-data huggingface dataset:
Protein: Regulator of sigma S factor FliZ (P52627)
Organism: Escherichia coli (strain K12)
Function: During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD.
Interaction partners:
- RNA polymerase sigma factor FliA
- Flagellar hook-associated protein 1
- Negative regulator of flagellin synthesis
- Flagellar basal body rod protein FlgB
- Flagellin
- Flagella synthesis protein FlgN
- Flagellar hook-associated protein 2
- Basal-body rod modification protein FlgD
- Flagellar protein FliL
- RNA polymerase sigma factor RpoS
Sequence:
MMVQHLKRRPLSRYLKDFKHSQTHCAHCRKLLDRITLVRDGKIVNKIEISRLDTLLDENGWQTEQKSWAALCRFCGDLHCKTQSDFFDIIGFKQFLFEQTEMSPGTVREYVVRLRRLGNHLHEQNISLDQLQDGFLDEILAPWLPTTSTNNYRIALRKYQHYQRQTCTRLVQKSSSLPSSDIY
Protein: rRNA adenine N(6)-methyltransferase (EC 2.1.1.-) (Q38BN0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerase
- Bystin, putative
- U3 small nuclear ribonucleoprotein
- Bms1-type G domain-containing protein
- Small-subunit processome Utp21 domain-containing protein
- Periodic tryptophan protein 2, putative
- Sas10 C-terminal domain-containing protein
- 40S ribosomal protein S5, putative
- RNA-binding protein NOB1
- Protein LTV1 homolog
Sequence:
MSRRFLNRSQVTSASAALLYSRRGVSKPSTDAAASPLPPLRCPGGPRVKAEGLKQLFKVPHAGYLAKYGQRFILNLKLTHQVAALLSRTTLRTPDKLLLELGPGAGALTRSLLTRPCVGVLGIEQDERFNGHLEQIRQYTNGKFQWTNGDVLRINELEIVESLYAGFAQQHRRKPAADARERASSDGNKSDGGEACSSGTKDSGCCTGDFYCEDAPLRNVQREKILRKRFGKYAAFNHDTASGQNSGSAAPSSDVSGCAFSSESVAFEVSDRWWSDGDAKLEVIANLPFNIITELLMRYAVDCSRKQNLFVFGRVPLHVFTQQEVAECIIAPAGSIHFSRLSVLCQCFFHTQLLRTFREMTYYPKTAVLGALITLQPRAVPLLPGLDAATLIHFTDLLMRPGQRGMTVYKALQQHVPPEVAQYMLQELRTDGALTVLDLTTEEVCKLATLWHRFLEASSQQAHGSGT
Protein: 40S ribosomal protein S3 (Q8IKH8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Mitochondrial ribosomal protein L20, putative
- 40S ribosomal protein S7
- 60S acidic ribosomal protein P0
- Ribosomal protein S27a, putative
- 60S ribosomal protein L30e, putative
- Small ribosomal subunit protein uS10
- 40S ribosomal protein S17, putative
- 40S ribosomal protein S19
- 40S ribosomal protein S4
- 60S ribosomal protein L13, putative
Sequence:
MSAPISKKRKFINDGVFQAELNEFLARILAEDGYSGVEVRVTPIRTEVIIRATRTREVLGDKGRRIRELTSLVQKRFFNKSTNSVELFAERVEHRGLCAMAQAESLRYKLLKGLAVRRACYGVLRHIMESGAKGCEVIVSGKLRAQRAKSMKFRDGYLISTGEPSKRFVNTATRSAQLKQGVLGIKVKIMLPTAIDTRTGLTSILPDNISVLEPKTDTVDL
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Bacteriocuprein) (P0AGD1)
Organism: Escherichia coli (strain K12)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Periplasm {ECO:0000269|PubMed:7589534, ECO:0000269|PubMed:7786035}.
Interaction partners:
- Catalase HPII
- Copper-exporting P-type ATPase
- Superoxide dismutase
- Superoxide dismutase
- Catalase-peroxidase
- Alkyl hydroperoxide reductase C
- Thiol:disulfide interchange protein DsbE
- DNA-binding transcriptional dual regulator OxyR
- Peroxiredoxin OsmC
- Trehalose-6-phosphate phosphatase
Sequence:
MKRFSLAILALVVATGAQAASEKVEMNLVTSQGVGQSIGSVTITETDKGLEFSPDLKALPPGEHGFHIHAKGSCQPATKDGKASAAESAGGHLDPQNTGKHEGPEGAGHLGDLPALVVNNDGKATDAVIAPRLKSLDEIKDKALMVHVGGDNMSDQPKPLGGGGERYACGVIK
Protein: Conserved protein (O53740)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Enoyl-CoA hydratase EchA2
Sequence:
MSRLSSILRAGAAFLVLGIAAATFPQSAAADSTEDFPIPRRMIATTCDAEQYLAAVRDTSPVYYQRYMIDFNNHANLQQATINKAHWFFSLSPAERRDYSEHFYNGDPLTFAWVNHMKIFFNNKGVVAKGTEVCNGYPAGDMSVWNWA
Protein: Dynactin subunit 2 (V9HW58)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
Protein: Sialic acid transporter NanT (Sialic acid permease) (Sialic acid/H(+) symporter) (P41036)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the proton-dependent transport of sialic acid. Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-D-glycero-D-galactonononic acid (KDN). Functions as a bidirectional transporter in vitro.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01238, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01238}.
Interaction partners:
- N-acetylneuraminate lyase
- Putative N-acetylmannosamine-6-phosphate 2-epimerase
- N-acetylmannosamine kinase
- N-acetylneuraminate anomerase NanQ
- HTH-type transcriptional repressor NanR
- N-acetylneuraminate epimerase
- N-acetylneuraminic acid outer membrane channel protein NanC
- Glucosamine-6-phosphate deaminase
- 2,7-anhydro-N-acetylneuraminate hydratase
- N-acetylglucosamine-6-phosphate deacetylase
Sequence:
MSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSAGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSAGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPIIGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNDLVKTKS
Protein: Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) (Q8TDG4)
Organism: Homo sapiens (Human)
Function: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.
Subcellular location: Nucleus {ECO:0000269|PubMed:21398521}. Chromosome {ECO:0000269|PubMed:21398521, ECO:0000269|PubMed:34937945}. Note=Localizes to sites of DNA damage; localizes to damaged replication forks. {ECO:0000269|PubMed:21398521, ECO:0000269|PubMed:34937945}.
Interaction partners:
- DNA polymerase nu
- DNA polymerase alpha catalytic subunit
- DNA repair protein RAD51 homolog 3
- DNA repair protein RAD51 homolog 1
Sequence:
MDECGSRIRRRVSLPKRNRPSLGCIFGAPTAAELVPGDEGKEEEEMVAENRRRKTAGVLPVEVQPLLLSDSPECLVLGGGDTNPDLLRHMPTDRGVGDQPNDSEVDMFGDYDSFTENSFIAQVDDLEQKYMQLPEHKKHATDFATENLCSESIKNKLSITTIGNLTELQTDKHTENQSGYEGVTIEPGADLLYDVPSSQAIYFENLQNSSNDLGDHSMKERDWKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAKAQTPIFSRSKQLKDTLLSEEINVAKKTVESSSNDLGPFYSLPSKVRDLYAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVIPNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQVLELITKPLENCYSHLVQEFTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSLWEITVESLRYLTEKGLLQKDTIYKSEEEVQYNFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNPDWMIYFRQFSQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKNVVNRLYLSFVLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFWVYRALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDHLSRRQAKQIVSSAKMLLHEKAEALQEEVEELLRLPSDFPGAVASSTDKA
Protein: Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029) (P19075)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:27180357, ECO:0000269|PubMed:34524408, ECO:0000269|PubMed:37204469, ECO:0000269|PubMed:37835445}; Multi-pass membrane protein.
Interaction partners:
- Integrin alpha-4
- Claudin-7
- Hematopoietically-expressed homeobox protein HHEX
- Epithelial cell adhesion molecule
- Insulin-like growth factor 2 mRNA-binding protein 2
- Threonylcarbamoyladenosine tRNA methylthiotransferase
- Proton-coupled zinc antiporter SLC30A8
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Leucine-rich repeat-containing G-protein coupled receptor 5
- Translation initiation factor eIF2 assembly protein
Sequence:
MAGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAIIMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQIGNK
Protein: Uncharacterized protein (Q57XR8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Splicing factor 3B subunit 1, putative
- PHD finger-like domain-containing protein 5A
- Spliceosome-associated protein, putative
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- RNA-binding protein, putative
- Sm protein B
- SURP motif domain-containing protein
- Probable eukaryotic initiation factor 4A
- Splicing factor 3B subunit 10
- Pre-mRNA-processing factor 19
Sequence:
MAARPAGSAAMGSGSRQASTNMNLIYHQTIIPTQKITHCVVGTFTLPGASDFVVVRHDTLELWTLHVNQNTAECVHSTRLFTNINQVATVPTVSEAVGQSSANRGGGILDSHPSSRRDQASGGSSALQRLAITSETGTMVLLRYDLDELPIPTRLMHDPTDSSKNDIPGTASTEHSQVTSLRGRFVRVSEVDLGRSGARLTVPGARLAVDPLGRAVFVAALMRQKIVVPLRKHEEYYTERINNRMMGGGLLNDEGDPNVLLMGDVTAVGNIGANDENTVDNSAGELSQRKKATVRDIISFGSPVEAHRQTMIYSICALDGATENATFAALEQELPEVNAGGGTGAAASPPPVVGGVAGQAYLRVNRSALQGGGANSSAKVKQLVVYAFASGLQQVQRTHLVPVPATAHRLVAVPATPFGPGGVLVCTDAEIIWYDVLPQVHGSGLRDGKGGDLTSSSSAQQHGGLGPLALFKTAAPFPRRADFREQLYDPMIVSHASTCVRNDFFMLLQDDQGDMFRVSLTLLDVQRSYDALRAAQQKQQQLRRNRGVLDAAEAAVPAITVPSPLVVTYFDTIPPTTAMALFRRGFVFAGSESAPTHGLYKIIKDGYGSDAEYILSRMRMVEQSRVDETRQRDKPLEDAKEGNGDTGGNNNGGDPSGETANGDGSTNGADKSNTGDRTASDSSVVNGGMGRRNDATGAMPPPALPAKGLAVPPAPSVLLRKQQPNSRVVPLFHPHQTLRHMVLLKSYPNTPPVASLIVGIPQGQQKQPQVQIDAVVGRGSDSVLFHARYGYAARLESSFTLQAVFTHLMPLASATGMQAQWLELQHETARSAAFLGVDNSSASGKRHSSKKRSYHSTHTSVCDDKLLLSTRQGTTVLSLGLGKQVEPDTLSGFITSEHTIAAGTLRYGVGYVQITPTCILVLPHHGDSVGSHYQQPAMATPMAEGVTWMHPHGKRILAADISGNTMVVSFTQAGGIASFDMGISGSRLQQLEMLPTFPHAPAVSLLRDPDGEANMFSARTLTSLSQPLTLAAIATVSQEVYIVSPKKLREPLETIRCTSVDDRDNCGTSATAGDAAPAITSVLLTYLGRKGGARRLFCFIGHIDGTVTRCELDHITYKVINRAVLTCGTAPCQMIAGDGERVCYILCGEFNWRCDVRDGMPKTVPWRFPTPQAMYAAFRRPAPPVATAGSGSGSNIESGVVTAAREELVLGVAGNTLSLFAAGVASTAAETGLEYSFSYTSLPVAGRRLLQHPTRPECLLVIGTEHRGYGVAALRRAASAARYKDGSSSGSGAAADGRPELSAGAGGIPLDKPQRSLNHPNYYVSTLQLYNRRTDRLDPPIYFQEGEAVLSAAVGSFVKDFGREPVVVLGCAEHFTHGSGLGVGASWTQGRLRAFRFVVSGASGPSGSSGPSLRLEQLHDTPIAVIAASSTGFEEDGNDDNTATQYGDQPTAPQSKGVGGAITDYPSALHICADVGLLFVGMGAASGLHVYAWGQRRFLRKRRLPNVPSRITSIETVFATPPNVVSSSSGTTAATTPGSTTYAADLYRCGPNSTNIVRERRLLIVCGTVDQSVFIATVQPGTSSGSVGSMSFLMLIARDAVPRSITCVACLDERTIAAGDRFGNVVFLRLPQDARLGFAEPVQNMTDIELVEAERYAASEQLLEEIAFHRAGQLVTSLRVHDYDPSDGTDPTLALRILFYATTLGAVGAYTPFVREEDAALAAHLQPLIASHVRCPLQGGSGQPVYNAAARLSTSPAAFTSVVHHVIEGDYAQLLLHSSTSLFSTEARSEMEAALAQKERAEAAQRNVLSLPKRVWPTLGELVAKQRALVALPP
Protein: Triggering receptor expressed on myeloid cells 3 (TREM-3) (Q9JKE1)
Organism: Mus musculus (Mouse)
Function: Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11754004}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- Plasmacytoid dendritic cell-specific receptor
- Trem-like transcript 2 protein
Sequence:
MSPLLLWLGLMLCVSGLQAGDEEEHKCFLEGENLTLTCPYNIMLYSLSLKAWQRVRSHGSPETLVLTNTRKADFNVARAGKYLLEDYPTESVVKVTVTGLQRQDVGLYQCVVYLSPDNVIILRQRIRLAWCQGKPVMVIVLTCGFILNKGLVFSVLFVFLCKAGPKVLQPSKTSKVQGVSEKQ
Protein: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC 2.1.3.15) (P0ABD5)
Organism: Escherichia coli (strain K12)
Function: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Subcellular location: Cytoplasm.
Interaction partners:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
- Biotin carboxylase
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Malonyl CoA-acyl carrier protein transacylase
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- DNA polymerase III subunit alpha
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- UDP-3-O-
Sequence:
MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLSTEDLKNRRYQRLMSYGYA
Protein: Adenine nucleotide alpha hydrolases-like superfamily protein (At5g14680) (Q9LYJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetratricopeptide repeat protein SKI3
Sequence:
MESEPTRVMVAVNESTLKGYPHASISSKKAFEWTLKKIVRSNTSGFKLLLLHVQVQDEDGFDDMDSIYASPDDFRQMRERNKAKGLHLLEFFVKKCHDIGVGCEAWIRKGDPTELICHEVRRVRPDFLVVGSRGLGPFQKVFVGTVSEFCVKHAECPVITIKRTAEESPQDPADD
Protein: Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM) (Q9Y6Q1)
Organism: Homo sapiens (Human)
Function: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17210638}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17210638}. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Interaction partners:
- Calpain small subunit 1
- Calpain small subunit 2
- Rho guanine nucleotide exchange factor 2
- Calpastatin
Sequence:
MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL
Protein: Protein L (Q51918)
Organism: Finegoldia magna (Peptostreptococcus magnus)
Interaction partners:
Sequence:
MKINKKLLMAALAGAIVVGGGANAYAAEEDNTDNNLSMDEISDAYFDYHGDVSDSVDPVEEEIDEALAKALAEAKETAKKHIDSLNHLSETAKKLAKNDIDSATTINAINDIVARADVMERKTAEKEEAEKLAAAKETAKKHIDELKHLADKTKELAKRDIDSATTINAINDIVARADVMERKTAEKEEAEKLAAAKETAKKHIDELKHLADKTKELAKRDIDSATTIDAINDIVARADVMERKLSEKETPEPEEEVTIKANLIFADGSTQNAEFKGTFAKAVSDAYAYADALKKDNGEYTVDVADKGLTLNIKFAGKKEKPEEPKEEVTIKVNLIFADGKTQTAEFKGTFEEATAKAYAYADLLAKENGEYTADLEDGGNTINIKFAGKETPETPEEPKEEVTIKVNLIFADGKIQTAEFKGTFEEATAKAYAYANLLAKENGEYTADLEDGGNTINIKFAGKETPETPEEPKEEVTIKVNLIFADGKTQTAEFKGTFEEATAEAYRYADLLAKVNGEYTADLEDGGYTINIKFAGKEQPGENPGITIDEWLLKNAKEEAIKELKEAGITSDLYFSLINKAKTVEGVEALKNEILKAHAGEETPELKDGYATYEEAEAAAKEALKNDDVNNAYEIVQGADGRYYYVLKIEVADEEEPGEDTPEVQEGYATYEEAEAAAKEALKEDKVNNAYEVVQGADGRYYYVLKIEDKEDEQPGEEPGENPGITIDEWLLKNAKEDAIKELKEAGISSDIYFDAINKAKTVEGVEALKNEILKAHAEKPGENPGITIDEWLLKNAKEAAIKELKEAGITAEYLFNLINKAKTVEGVESLKNEILKAHAEKPGENPGITIDEWLLKNAKEDAIKELKEAGITSDIYFDAINKAKTIEGVEALKNEILKAHKKDEEPGKKPGEDKKPEDKKPGEDKKPEDKKPGEDKKPEDKKPGKTDKDSPNKKKKAKLPKAGSEAEILTLAAAALSTAAGAYVSLKKRK
Protein: Loganic acid O-methyltransferase (CrLAMT) (EC 2.1.1.50) (B2KPR3)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vinblastine and ajmalicine) biosynthesis pathway. Catalyzes the methylation of loganic acid (6S,7R) to produce loganin. Weak activity with secologanic acid as substrate. Inactive on deoxyloganic, dehydrologanic, epiloganic and loganetic acid.
Interaction partners:
Sequence:
MVATIDSIEMPALPTAVEAHPMKGGDDSHSYSQNSCYQKGVIDAAKAVIVEAVNEKLDLENNPIFDPIKPFRIADFGCSTGPNTFHAMQNIVESVETKYKSLQKTPEFHVFFNDHVNNDFNVLFRSLPPNREFFAAGVPGSFYTRVFPKNSIHFAHCSYALHWLSKVPKEIQDKNSLAYNKGRIHYTGTEKHVVKAYFGQFQRDFEGFLKARAQEIVVGGLMVIQIPGLPSGEVLFSRTGAGLLHFLLGTSLMELVNKGIINEESVDSFNLPQYHPSVEDLEMVIEMNDCFTIERVGTLPHPMKNLPFDVQRTSLQVRAIMECILTEHFGENILDPLFEIYTKNLQENFHVFDKEIRKDADLYLVLKRKGN
Protein: Proteasome-interacting protein CIC1 (Core interacting component 1) (P38779)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11500370, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Nuclear GTP-binding protein NUG1
- Ribosomal RNA-processing protein 1
- Nucleolar GTP-binding protein 2
- 27S pre-rRNA
- Ribosome production factor 1
- 60S ribosome subunit biogenesis protein NIP7
- Ribosome biogenesis protein RLP24
- Ribosome biogenesis protein YTM1
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein SSF1
Sequence:
MAKKSNSKKSTPVSTPSKEKKKVIEKKSSTAIPRERVIKAVNELIKFTSKPQDENNEEGNNGKKNLLEDDEEELKKDLQLIVVNNKSFTGTSKSFKLKLLNVKHSFYKPWKEASATAVKDFKVLLILKDSDIKKVSEDDLFDQLDSEGIKVDEIICGKDLKTVYKAYEARNAFISQFSLILADDSIVTSLPKLMGGKAYNKVETTPISIRTHANKEFSLTTLTNNIKKVYMNQLPVKLPRGTTLNVHLGNLEWLRPEEFVDNVELISEQLIKAYQIRSIFIKTNRSPVLPLYYNQDVLDELEAKKDKIEETHEDDMVTIDGVQVHLSTFNKGLMEIANPSELGSIFSKQINNAKKRSSSELEKESSESEAVKKAKS
Protein: 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B) (P46636)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P28222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28222}.
Interaction partners:
Sequence:
MEEQGIQCAPPPPAASQTGVPLVNLSHNCSAESHIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPVSTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYAAKRTPKRAAIMIALVWVFSISISLPPFFWRQAKAEEEVLTCLVNTDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTTSVTSINSRAPDLPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMATLDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG
Protein: Frizzled 7b (Q90ZT3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAFLKMQHCCGITRYFLLLFTVALQTTSGQYHGEKGISIPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPTSNPTPYVPELITLQPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEKDCGAPCEPTRPNGLMYFREEEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCIDKFSDDGYKTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVYGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEELEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHMQTCKRFAVPCPINNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRLSNSNQGETTV
Protein: Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7) (Q8CGW9)
Organism: Mus musculus (Mouse)
Function: May be involved in sexual development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- Ly6/PLAUR domain-containing protein 4
- KICSTOR complex protein kaptin
- KICSTOR complex protein ITFG2
- GATOR1 complex protein DEPDC5
- KICSTOR complex protein SZT2
- GATOR1 complex protein NPRL2
Sequence:
MDPSETAALHHCSADSSPADEARVPQSTELIPRRPVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLAQGLMKGATPLKAPLRVKKGAIRPGIPSGKENIAPQPQSPHGAVPLVLTPPGKENYGPLLLSRPPEALPLPWTPVPPGPWGPGHWLPPGLSMPPPVVCRLLCQEPAVPLHPFPGFDPGTSLRLPTHGTLPTCPGSRSVLTAPLSGEPQGPPNLPHTCSTLILQSCGTPDSLLLQPQAPGASCLAWTSGPSERQLQREAAEALVGLKDSSQAPRLTPSVPPNPAWISLLHPCGPPAPPGGRGFQPVGPPLRPSPGSSVSLHIGRLGSISLLS
Protein: Erythrocyte membrane protein band 4.1-like 3 (A0A8I6AAL7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTTESGSDSESKPDQEAEPQEAAGPQEQAGAQAAPEPAGGNVEEQPGLEQFPEAAAHSTPVKREVSDKDRDFAAAAAKQLEYQQFEDDKLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDRRKKAEEATPVAALRHEGKTDSERTDTAADGETSATESDQEEDAELKAQELDKTQDELVKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKEEREISEKVVFLQQGTSPFLESQGTEDWVIVDKIPTEVVDGDSKKIVTYKVVTVSSKTGEIPADLLKSGMVDMYGFDDLAREMQLKEENKQKVYTLGKSYDTVSGRIVTMTGKAKDSERGPQPSTLEGLQKMESGASEALRVGPLLVEYEVLEALTEKSGRAPEVQTPKRRLSESLAPIKEAESRRQSPEEDDTQKAPKLGEDAPAHLRSSKTQQVPECEVLKVGPFGPRRKSLSEWRYSREPAFTVATAHYVTESSASQVVTKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTETIETEVEPTPHPQPLSTEKVLQETVLVEERHVMNVHASGDASHTARDDVDATESAPADRHSGNGKEGSSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVESISVGSVSPGGVKLETSTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED
Protein: Histone H3 (C1BGA8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCATHAKRVTIMPKDIQLARRIRGERA