wanglab/gogpt-training-data huggingface dataset:
Protein: Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) (P48317)
Organism: Rattus norvegicus (Rat)
Function: Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cyclin-dependent kinase 1
- Cellular tumor antigen p53
- G2/mitotic-specific cyclin-B1
- Proliferating cell nuclear antigen
- G/T mismatch-specific thymine DNA glycosylase
- Growth arrest and DNA damage-inducible protein GADD45 gamma
- Growth arrest and DNA-damage-inducible, beta
- Aurora kinase A
- Methylcytosine dioxygenase TET
- Cyclin B3
Sequence:
MTLEEFSAAEQKIERMDTVGDALEEVLSKARSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIRAFCCENDINILRVSNPGRLAELLLLENDKSPAESGGLAQTPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER
Protein: Geranylgeranyl transferase type-2 subunit beta 2 (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta 2) (Rab geranylgeranyl transferase beta subunit 2) (AtRGTB2) (Rab-GGT beta 2) (Q9LHL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -CCXX, CXXX, -XCCX and -XCXC, such as RABA1A, RABA2A, RABF2A and RABG2. In vitro, can prenylate PGGTI targets with the C-terminal sequence Cys-aliphatic-aliphatic-X (CaaX) with leucine in the terminal position. Substrates with the C-terminal sequence -CSIL such as ARAC11/ROP1 or GG2/AGG2 are prenylated independently of REP and when the beta subunit is associated with the alpha subunit RGTA1.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit alpha 1
- Rab escort protein 1
- Geranylgeranyl transferase type-2 subunit alpha 2
- Protein prenylyltransferase superfamily protein
- Ras-related protein RABD2b
- Geranylgeranyl transferase type-2 subunit beta 1
- GPN-loop GTPase QQT1
- Ras-related protein RABA4d
- Ras-related protein RABA2a
- Ras-related protein RABE1a
Sequence:
MADKLVAGKHLRYILNLMAEKKKESFESVVMDHLRMNGAYWGLTTLALLDKLGSVSEDEVVSWVMTCQHESGGFAGNTGHDPHVLYTLSAVQILALFDKLNILDVEKVSNYIAGLQNEDGSFSGDIWGEVDTRFSYIAICCLSILKCLDKINVKKAVDYIVSCKNLDGGFGCSPGAESHAGQIFCCVGALAITGNLHRVDKDLLGWWLCERQDYESGGLNGRPEKLPDVCYSWWVLSSLIMIDRVHWIEKAKLVKFILDSQDMDNGGISDRPSYTVDIFHTYFGVAGLSLLEYPGVKTIDPAYALPVHVINRILFTK
Protein: Cysteine synthase B (CSase B) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase B) (OAS-TL B) (O-acetylserine sulfhydrylase B) (P16703)
Organism: Escherichia coli (strain K12)
Function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.
Interaction partners:
- Serine acetyltransferase
- Sulfate/thiosulfate import ATP-binding protein CysA
- Sulfite reductase hemoprotein beta-component
- Sulfate transport system permease protein CysW
- Sulfite reductase flavoprotein alpha-component
- Phosphoadenosine 5'-phosphosulfate reductase
- Sulfate adenylyltransferase subunit 2
- Adenylyl-sulfate kinase
- Sulfate adenylyltransferase subunit 1
- Thiosulfate-binding protein
Sequence:
MSTLEQTIGNTPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALEMANRGEGKLLDQFNNPDNPYAHYTTTGPEIWQQTGGRITHFVSSMGTTGTITGVSRFMREQSKPVTIVGLQPEEGSSIPGIRRWPTEYLPGIFNASLVDEVLDIHQRDAENTMRELAVREGIFCGVSSGGAVAGALRVAKANPDAVVVAIICDRGDRYLSTGVFGEEHFSQGAGI
Protein: Chromosome 11 open reading frame 54, isoform CRA_b (Epididymis secretory sperm binding protein) (A0A024R3B0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MACAEFSFHVPSLEELAGVMQKGLKDNFADVQVSVVDCPDLTKEPFTFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPFQTLGFNSEFMPVIQTESEHKPPVNGSYFAHVNPADGGCLLEKYSEKCHDFQCALLANLFASEGQPGKPAEFSSCPLNSDEEVNKWLHFYEMKAPLVCLPVFVSRDPGFDLRLEHTHFFSRHGEGGHYHYDTTPDIVEYLGYFLPAEFLYRIDQPKETHSIGRD
Protein: Transcription regulatory protein SNF11 (SWI/SNF complex component SNF11) (P38956)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription regulatory protein SNF2
- Transcription regulatory protein SNF6
- SWI/SNF chromatin-remodeling complex subunit SNF5
- Transcription regulatory protein SNF12
- SWI/SNF complex subunit SWI3
- SWI/SNF global transcription activator complex subunit SWP82
- SWI/SNF chromatin-remodeling complex subunit SWI1
- Transcription initiation factor TFIID subunit 14
- Actin-related protein 7
- Actin-like protein ARP9
Sequence:
MSSEIAYSNTNTNTENENRNTGAGVDVNTNANANANATANATANATANATAELNLPTVDEQRQYKVQLLLHINSILLARVIQMNNSLQNNLQNNINNSNNNNIIRIQQLISQFLKRVHANLQCISQINQGVPSAKPLILTPPQLANQQQPPQDILSKLYLLLARVFEIW
Protein: BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl) (Q9NP55)
Organism: Homo sapiens (Human)
Function: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
Subcellular location: Secreted {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:12409287, ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:26559477}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
Interaction partners:
- BPI fold-containing family B member 1
- BPI fold-containing family B member 4
- Phospholipid transfer protein
- Cytochrome c oxidase subunit 7B2, mitochondrial
- BPI fold-containing family B member 2
- BPI fold-containing family B member 6
- Cholesteryl ester transfer protein
- Lactotransferrin
- BPI fold-containing family A member 2
- Bactericidal permeability-increasing protein
Sequence:
MFQTGGLIVFYGLLAQTMAQFGGLPVPLDQTLPLNVNPALPLSPTGLAGSLTNALSNGLLSGGLLGILENLPLLDILKPGGGTSGGLLGGLLGKVTSVIPGLNNIIDIKVTDPQLLELGLVQSPDGHRLYVTIPLGIKLQVNTPLVGASLLRLAVKLDITAEILAVRDKQERIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVCPLVNEVLRGLDITLVHDIVNMLIHGLQFVIKV
Protein: Zgc:92747 (Q6DGW2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSGLNSSLGFFLAVVGLSVSGRLLLRRWTVLLELVSAFALCACRLEVDTIAEVGQWAGALGPDVAVTMLFLSIAVHTAVMQDVSGNPAVTLLRLLQRDVSVVVAVLSIAAQLIGAFLALEVAGRFWAMELSDMHMITNAEGPCALCGAHAHRLHREQLHIWICESGPGLRCDLHLSWTLVPGVFTGLLARTTHWCVSCSLPVFGKYPTAVQQESALLQEKSLPAAERKNQ
Protein: Galactokinase (EC 2.7.1.6) (Galactose kinase) (P04385)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Bifunctional protein GAL10
- Galactose/lactose metabolism regulatory protein GAL80
- Regulatory protein GAL4
- Galactose transporter
- Protein GAL3
- Orotidine 5'-phosphate decarboxylase
- 3-isopropylmalate dehydrogenase
- N-
- Imidazoleglycerol-phosphate dehydratase
Sequence:
MTKSHSEEVIVPEFNSSAKELPRPLAEKCPSIIKKFISAYDAKPDFVARSPGRVNLIGEHIDYCDFSVLPLAIDFDMLCAVKVLNEKNPSITLINADPKFAQRKFDLPLDGSYVTIDPSVSDWSNYFKCGLHVAHSFLKKLAPERFASAPLAGLQVFCEGDVPTGSGLSSSAAFICAVALAVVKANMGPGYHMSKQNLMRITVVAEHYVGVNNGGMDQAASVCGEEDHALYVEFKPQLKATPFKFPQLKNHEISFVIANTLVVSNKFETAPTNYNLRVVEVTTAANVLAATYGVVLLSGKEGSSTNKGNLRDFMNVYYARYHNISTPWNGDIESGIERLTKMLVLVEESLANKKQGFSVDDVAQSLNCSREEFTRDYLTTSPVRFQVLKLYQRAKHVYSESLRVLKAVKLMTTASFTADEDFFKQFGALMNESQASCDKLYECSCPEIDKICSIALSNGSYGSRLTGAGWGGCTVHLVPGGPNGNIEKVKEALANEFYKVKYPKITDAELENAIIVSKPALGSCLYEL
Protein: Ribosomal protein L22p/L17e (Q57Y86)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 50S ribosomal protein L16, putative
- 50S ribosomal protein L17, putative
- Mitochondrial RNA binding complex 1 subunit
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Large ribosomal subunit protein uL3m
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MPRPAPRFAMGHMLPHRSNVGSQFLHTQRHGSRSTWYKKHYFSLRPFAIQRHHGTTPRILLDRSLWKSLWITKLQLPDINRWERVVNSQRVTEDRYAFVEEEGVMHKVNWGLYCERLETELTVTQERLPQHTLLMKAAPSSWKKLDIDISVIRGLSLREAMAQCKLSLRKGHQIVFRALEMAQQGAEAKGLDKEHLRVAHISCYPGPTDKQIDIRSKGYYAWKTKKSSHLVLTLAEDPEMVLPDRTCLPYSSLMSMKRAGLSAQPTVIDVPAITAEGI
Protein: Small nuclear ribonucleoprotein polypeptide N (J3QLE5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNAKQPEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGVGRAAGRGVPAGVPIPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAVAATASIAGAPTQYP
Protein: AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) (Q8BG26)
Organism: Mus musculus (Mouse)
Function: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth (By similarity). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22404429}. Nucleus {ECO:0000250|UniProtKB:Q9BVN2}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22404429}. Cytoplasmic vesicle {ECO:0000305|PubMed:22404429}. Early endosome {ECO:0000305|PubMed:22404429}. Postsynaptic density {ECO:0000269|PubMed:22404429}. Golgi apparatus {ECO:0000305|PubMed:22404429}. Note=Translocated to the nuclear envelope upon stimulation with NGF (By similarity). Associated with membranes and microtubules (PubMed:22404429). {ECO:0000250|UniProtKB:Q9BVN2, ECO:0000269|PubMed:22404429}.
Interaction partners:
Sequence:
MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELREGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGSSIENQQDPSQEEEAVSPSDPGCSSSLSSCSDLSPDESPVSVYSRDLPGNEDANPQPSTLELGSPLAPAGPSTCSPDSFCCSPDSCSGISSPPGPDLDSNCNALTTCQDLPSPGLEEEEDSGEQDLATSELSETEDGRIDAGKAEPSWKINPIWKIDTEKTEAGWKTIEDSDSGRKTDENTNSSLKTESGKLASCLNTNSGSKIDAGKTDGGWRGDVSQEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPTGSLGGSLAPPREVTTFKELRSRSRAQPPPVPPRDPPAGWALVPPRPPPPPVPPRRKKNRLGLQPIAEGLSEEGRAASPRAGEEASASQEPEEPRAHAVVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSASVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSCTHSMGSLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGSCPSLATELLLLLQPLSVLTFHLDLLFEHHHHLPVGLQQAPAPSCPPPALQQTMQAVLHWGERLAQSLRGTSGESTTDSSTPSARPPAGSWWDQLTQASRVYASGGTEGFPLLRWGPRRHGTTAEAAQEAPPPTEQTTPGRSVWLGRLFGVPGCPSETESGAFKSRRPSSWLPPTVSVLALVKRGTPPETPPEALVSSPGSVVQADRAVRALCDHTAAGPDQLSFQRGELLRVIATVDEDWLRCGRDGVEGLVPVGYTSLVL
Protein: Protein transport protein Sec24C (SEC24-related protein C) (P53992)
Organism: Homo sapiens (Human)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10075675, ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10075675, ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Cytoplasm, cytosol {ECO:0000269|PubMed:10075675}.
Interaction partners:
- Protein SEC13 homolog
- Protein transport protein Sec16A
- Protein transport protein Sec23B
- Protein transport protein Sec23A
- Protein transport protein Sec24A
- Protein transport protein Sec31A
- Small COPII coat GTPase SAR1A
- Protein transport protein Sec24D
- Protein transport protein Sec24B
- Protein transport protein Sec31B
Sequence:
MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVESTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS
Protein: Olfactory receptor 51L1 (Olfactory receptor OR11-31) (Q8NGJ5)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Proline-rich protein 35
Sequence:
MGDWNNSDAVEPIFILRGFPGLEYVHSWLSILFCLAYLVAFMGNVTILSVIWIESSLHQPMYYFISILAVNDLGMSLSTLPTMLAVLWLDAPEIQASACYAQLFFIHTFTFLESSVLLAMAFDRFVAICHPLHYPTILTNSVIGKIGLACLLRSLGVVLPTPLLLRHYHYCHGNALSHAFCLHQDVLRLSCTDARTNSIYGLCVVIATLGVDSIFILLSYVLILNTVLDIASREEQLKALNTCVSHICVVLIFFVPVIGVSMVHRFGKHLSPIVHILMADIYLLLPPVLNPIVYSVRTKQIRLGILHKFVLRRRF
Protein: Interleukin-36 receptor antagonist protein (IL-36Ra) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 homolog 3) (IL-1H3) (Interleukin-1-like protein 1) (IL-1L1) (Q9QYY1)
Organism: Mus musculus (Mouse)
Function: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UBH0}. Secreted {ECO:0000250|UniProtKB:Q9UBH0}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:Q9UBH0}.
Interaction partners:
- Interleukin-1 receptor-like 2
- Interleukin-1 receptor type 1
- Interleukin-36 beta
- Interleukin-1 receptor accessory protein
- Interleukin-36 alpha
- Interleukin-36 gamma
- Interleukin-6
- Interleukin-18
- Interleukin-18 receptor 1
Sequence:
MMVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD
Protein: E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) (Q8BH75)
Organism: Mus musculus (Mouse)
Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 8
- Receptor tyrosine-protein kinase erbB-3
- Protein CLEC16A
- Epidermal growth factor receptor
- Serine/threonine-protein kinase TBK1
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
- Vacuolar protein sorting-associated protein 52 homolog
- Ankyrin repeat and SOCS box protein 6
- E3 ubiquitin-protein ligase parkin
- Receptor tyrosine-protein kinase erbB-2
Sequence:
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
Protein: Suppressive immunomodulating factor (Q581S0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIPPAKLNDFFNIVDDFLKKTFRDESFLFAAVKSRQYSESFPGEQLFFTSPPSATTDQPSDESLQAGGGELRKTQNFMYFSPRLIFNRDGGYHGKVKLHSGVHVPQVCRFEQGIAVNSEGLASGSVKVSDLLEGMEVKGRLAVNTIAPPSKDVWSVAMDYQRRDFYSTLNYQRNGLGSSDLLVDCGTKFFNLLAGAGFERQKVSFLEQQDHTAQLDVLYAGVGFTGVNWSVGAKLVRANDMWSAARIAFYQRVVPDTSVACAYNFDMEESRVHVSLGFSQGFRLRVPTILQQRACEQLDVWTAILPFVGAFKAESGGLCAATIRGIFNGVVHWGLVAQKNVLVENSPIRFGLTLSVESG
Protein: G-patch domain-containing protein C1486.03 (Q9UTK6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43
- Pre-mRNA-splicing factor cwf4
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor spp42
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf2
- Small nuclear ribonucleoprotein-associated protein B
- Pre-mRNA-splicing factor cwf3
- Pre-mRNA-splicing factor prp5
Sequence:
MQNEYVDMNSSSEDSDGDSILEEGRLRPSFRGQQKERDMLGIFGEEDEDGFHNSGIGSARLRRKNISFVEKSEQVKANKQVTADDLLEAHSIPQLKNKNDEVSQAKNIPKMKFNTTGFGAKMLEKMGYKQGQGLGANAEGIAEPVQSKLRPERVGLGAVRERTEKQRKEAIARGEISDSEDEKHTVKQKPLREKKKKPLKSSEEISKDMGSYNLPRFLASLIDASLNDTKEIEFVTSNKEELGLEGRDMSTSGINQLSRLARVECEHHASAWQQLQARRAYVKMELKRVTTEFDEKSVEISRLEKLLGKVMEVKSRSMEFTVPEAEIDVIEKRLQPLNNLIETLPVEFSEASMHFELDSVAVSILAFVLSEPIKNWDVWKHPYFMLESFLSWKNSLYSKDFRPKREESSTFMDIDVEFDDELEGQSLTHYESFMMFVWKKKIGEELKKWIIQDSLKALQLLEAWDPVVPEKVKDSLIQDDILPRLKDAVSKWNPKLKLKKNDSLHHCIFPWLPYLEKHADSLLQSVLVQFSLILSPWKIKNGSIDDFSVWRSAFANDALDRLLEKVILPKLEKLMDEELVIDPSNQDLEIFFIILSWKGSFKAMVFGQLFADHFFPKWLETLYQWLTEAPNFDEASEWYTWWKSVFPKDLLSNAYIQQGFSKGLDMMNECLENKSITAPLPFAKDSTKGVNLQFSKEKHEFTAESDDTTSYDEPLVSFRELVEEFCAENSLLFVPLRRSHLSTGSALFRISTQASKARGITVYLRNDIIWKKSPGASEDTPYDPIGFNEILLMFNNN
Protein: Regulatory protein YycH-like domain-containing protein (Q2G2U2)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Interaction partners:
- Regulatory protein YycH domain-containing protein
- Sensor protein kinase WalK
- Transcriptional regulatory protein WalR
- Metallo-beta-lactamase domain-containing protein
- Elastin-binding protein EbpS
- Septation ring formation regulator EzrA
- DUF2529 domain-containing protein
- UPF0354 protein SAOUHSC_01859
- 5-bromo-4-chloroindolyl phosphate hydrolase
Sequence:
MNWKLTKTLFIFVFILVNIVLVSIYVNKVNRSHINEVESNNEVNFQQEEIKVPTSILNKSVKGIKLEQITGRSKDFSSKAKGDSDLTTSDGGKLLNANISQSVKVSDNNLKDLKDYVNKRVFKGAEYQLSEISSDSVKYEQTYDDFPILNNSKAMLNFNIEDNKATSYKQSMMDDIKPTDGADKKHQVIGVRKAIEALYYNRYLKKGDEVINARLGYYSVVNETNVQLLQPNWEIKVKHDGKDKTNTYYVEATNNNPKIINH
Protein: Zinc finger CCCH domain-containing protein 54 (AtC3H54) (Tandem CCCH Zinc Finger protein 6) (AtTZF6) (O65036)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Embryo-specific transcription factor required at the globular to heart stage transition in embryo development.
Subcellular location: Nucleus {ECO:0000305|PubMed:9501112}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 37
- Zinc finger CCCH domain-containing protein 17
- Zinc finger CCCH domain-containing protein 15
- Zinc finger CCCH domain-containing protein 14
- Zinc finger CCCH domain-containing protein 68
- Zinc finger CCCH domain-containing protein 43
- Zinc finger CCCH domain-containing protein 12
- tRNA-dihydrouridine
- AGAMOUS-like-56
- Zinc finger CCCH domain-containing protein 5
Sequence:
MLKSASPMAFYDIGEQQYSTFGYILSKPGNAGAYEIDPSIPNIDDAIYGSDEFRMYAYKIKRCPRTRSHDWTECPYAHRGEKATRRDPRRYTYCAVACPAFRNGACHRGDSCEFAHGVFEYWLHPARYRTRACNAGNLCQRKVCFFAHAPEQLRQSEGKHRCRYAYRPVRARGGGNGDGVTMRMDDEGYDTSRSPVRSGKDDLDSNEEKVLLKCWSRMSIVDDHYEPSDLDLDLSHFDWISELVD
Protein: GH12419p1 (Stargazin-like protein) (Q9VRE6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Glutamate receptor 1
- Sol1, isoform C
- Ca2+-channel-protein-beta-subunit, isoform L
- Glutamate receptor IB, isoform B
- Voltage-dependent calcium channel type D subunit alpha-1
- Voltage-dependent calcium channel type A subunit alpha-1
Sequence:
MRDYPSVPNVFRVASTHSINSENPYNNIRPANVICNTTERPPIAIHQLTTSASIEHSHPSQQAQHQQQQLLHHQQQHHHQQHSPYATLPRGQRLAPQQHQQAGVINTISGSIPATGFSSLAGSFSDLQLNNIGNHSSNSRSNHNSISNNRRQQQQQQQQQQQRLVPHLSRHQPAIEVQQTQQHQQTQQQHVQRQQQQERLASGGAGATDPQGGISNMTTVNGGYLWLITPVAASISVAIVIAALAGPQWLFTEEKLPNANYNGTANFKALDDGAYITKYTKSSLWILCTTLPGLDADSYNCVKIDYFSNEGYQPDPHDSTAAIPYTVTKSCPIFLAAGVFLVISFIVFLIPTCSHQNNLYYFSAGILFIVSGLVMLIGLIAYISILKAEIGSKLRPRSTLQPALIKVSYGQSFFLFVFGFIVTEFVGVLNIFLFINLQEVSYYSVSN