wanglab/gogpt-training-data huggingface dataset:
Protein: Hemocyanin subunit 1 (P84846)
Organism: Necora puber (Velvet swimming crab) (Macropipus puber)
Function: Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:P84293}.
Interaction partners:
Sequence:
DSPAGVSDAQKQ
Protein: Uncharacterized protein C11C11.01 (Q10200)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor sap62
- U2 snRNP component prp10
- Pre-mRNA-splicing factor sap61
- Small nuclear ribonucleoprotein Sm D1
- Pre-mRNA-splicing factor prp12
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein-associated protein B
- Spliceosome-associated protein 49
- Pre-mRNA-splicing factor sap114
- Small nuclear ribonucleoprotein F
Sequence:
MKKNNERVNTNPSLISKSYNMKKRPVIGTRRHFARKEIESDSDDEDDIFLAGERKKYLQNQSYERRKQKNEHGNNLTLQEELLRHEAYEKNEEIANENDVDQVNLMKYFVHMDNISPVTTNGSLKESLRKYSSIIAVNIFSETGDLKKGIAIFQDLSDAEQAVQYLSNCKIDGRLISATITNHPKRLPNAEHLESSTKTKDESQDKDKLTKLDRAKLEWLIQGLNCEKGSIGNLLCFAVEHVNNHVEITDAFLKEFFNDQPTDDTKVYDDDYINERGEKKLSLIYLMNDILFNGISGTSLVWRYRFSFEPHVERLLDDLYLFSKRLGGRIKEDIFCKKVVKVIEVWKTWIAFQEETLERAWRNFSGNTPQSPQINSAALKVETKNSWTAISEETEGLQDDEEYNGIPVDVNELLNVEFISQIPMSTETSSSSSPQPTEERKAKFKPSFTQGTFVSKRMRMHAEDLF
Protein: Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein] (P03406)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
Function: Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.
Subcellular location: Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:19781555}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:19781555}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:19781555}. Virion {ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:8623533, ECO:0000269|PubMed:9765428}. Secreted {ECO:0000255|HAMAP-Rule:MF_04078}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:19781555}. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved. {ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:19781555, ECO:0000269|PubMed:8623533, ECO:0000269|PubMed:9765428}.
Interaction partners:
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
Protein: Trophinin (MAGE-D3 antigen) (Q12816)
Organism: Homo sapiens (Human)
Function: Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
Interaction partners:
- Tastin
- Bystin
Sequence:
MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG
Protein: Multivesicular body subunit 12A (E9PQA6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDPVPGTDSAPLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKSFAQKSGYFLCLSSLGSLENPQENVVADIQIVVDKSPLPLGFSPVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVPGYLRIGDMGGFAIWCKKAKAPRPVPKPRGLSRDMQGLSLDAASQPSKGGLLERTASRLGSRASTLRRNDSIYEASSLYGISAMDGVPFTLHPRFEGKSCSPLAGLPSSRNTLKAARQTHIRCLESGGFGCSPRTSLALRLT
Protein: Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Histocompatibility antigen modifier 2) (P36371)
Organism: Mus musculus (Mouse)
Function: ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q03519}; Multi-pass membrane protein {ECO:0000255}. Note=The transmembrane segments seem to form a pore in the membrane. {ECO:0000250|UniProtKB:Q03519}.
Interaction partners:
- Antigen peptide transporter 1
- Tapasin
- Calreticulin
- Calreticulin
- Protein disulfide-isomerase A3
- Beta-2-microglobulin
- H-2 class I histocompatibility antigen, K-B alpha chain
- ABC-type oligopeptide transporter ABCB9
- Proteasome subunit beta type-9
- Proteasome subunit beta type-8
Sequence:
MALSYLRPWVSLLLADMALLGLLQGSLGNLLPQGLPGLWIEGTLRLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWLLAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVEHDQLRDGQDVYAHLVQQRLEA
Protein: Defective chorion protein, FC125 isoform (P18169)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for proper assembly of the eggshell.
Subcellular location: Secreted {ECO:0000269|PubMed:3378704}.
Interaction partners:
Sequence:
MRLFSLLPLLALLVVQAAGQSEVTSDDPATDAGSTTNSTTDTKPRIPSQDEILGQMPSINPIRTGNPQMDAFYMMFPALGSLLKWGSLFPAYSILGAIPDNLQPTAAASKVVLVLADDATAKTRVARQNPPPNPLGQLMNWPALPQDFQLPSMDLGPQVGSFLAQLPAMPTVPGLLGAAAPVPAPAPAPAAAPPPAPAPAADPPAAPVPDAPQPAILGQAALQNAFTFFNPANFDASSLLGQSVPTFAPPNLDFVAQMQRQFFPGMTPAQPAAAGTDAQASDISEVRVRPEDPYSQEAQMKIKSALEMEQERQQQAQVKDQEQVPLLWFRMPTTQNQDATEEKTLEDLRVEAKLRAFERQVIAELRMLQKIELMAKQMRSSAAAQNGDSPYRISYPLSRTPIHKITRADIEQALRDDYVRRLVNKEAQRRARNSGINTQKANALKRQAKSQDQTLSKEDIVQIMAYAYRMANEQMESEKGKQDKVYAAYRTEQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMVQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQHDQQMAQQMAQQGLMMTEQRQRQWSEDQAKIQQAQQMAQQTPMMMPQMQQRQWTEDPQMVQQMQQRQWAEDQTRMQMAQQNPMMQQQRQMAENPQMMQQRQWSEEQTKIEQAQQMAQQNQMMMQQMQQRQWSEDQAQIQQQQRQMMQQTPMMMKERQWAEENPQSVQQQGPMMMQQQMPSMMQREVEDEDNKAEDDLVGEAGPQMPENEGTARHKVDALGVGGNKRKKSKSKSAPPTVINYYYAAPQRPVVQSYGTSYGGGGYGSNAYGVPRPVNSYQSQGYRAAVGNDEVDEMLRQHQTMARTINPKQPGEVGGSESQKSNSNPPTTLTPAPQEQPQEHRVHKSPSSAPSETEIENAPSSDPQVGSIFTYGEGLLHPFMGLLPVERPDDPWNQKPYDPHHPLYTGGGSYDAYLRDGRHRRDTHIMGQGTQHGILTPGMLERLLRIKMDFQRRFPHLYKGMLNHHTNLTRVEVQPPVLGKISKPKTKTKPKNEDEPVFELGAAERSLFEDETNDSLEKDPEPEPDEEDDRDVEEPSESSEPRGFSSKKSRDENDIDYFNFDDDDVDD
Protein: Probable transcriptional regulatory protein (O53921)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Transglutaminase-like domain-containing protein
- Probable conserved integral membrane transport protein
- HTH-type transcriptional regulator Cmr
- Probable transcriptional regulatory protein
- Uncharacterized HTH-type transcriptional regulator Rv0494
- HTH-type transcriptional regulator Rv1931c
- Putative mycofactocin biosynthesis transcriptional regulator MftR
- Transcriptional regulatory protein EmbR
- Possible transcriptional regulatory protein NadR
- Possible transcriptional regulatory protein
Sequence:
MSGAKKLIFEQFALVGQALSSGHRLELLDLLVQGERSVDALARASGLTFANASQHLLQLRRAGLVTSRRDGKRVIYALSDPQVWDVVRAVRAVAERNLASVGSLVRQYYTDRDSLEPISRDELQARVAAGSVLVLDVRPAMEYAAGHLPGAVSIPLDELAERLDELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLAADLPVVRT
Protein: 5'-3' exoribonuclease 3 (AtXRN3) (EC 3.1.13.-) (Protein EXORIBONUCLEASE 3) (Q9FQ03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA-derived loops, excised during miRNA maturation in the nucleus. Required for proper development. Involved in pre-rRNA processing. Involved with XRN2 in the 5'-end exonucleolytic processing of 5.8S and 25S rRNAs. Contributes with XRN2 to polyadenylation-dependent nuclear RNA surveillance. Involved in the degradation of aberrant polyadenylated pre-rRNA through 5'-end processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:11106401}.
Interaction partners:
- NAD-capped RNA hydrolase DXO1
- 3'
- 5'-3' exoribonuclease 2
- Lysine-rich arabinogalactan protein 17
- DExH-box ATP-dependent RNA helicase DExH9
- mRNA-decapping enzyme subunit 2
- DExH-box ATP-dependent RNA helicase DExH11
- DExH-box ATP-dependent RNA helicase DExH10
- mRNA-decapping enzyme-like protein
- Exosome complex exonuclease RRP44 homolog A
Sequence:
MGVPSFYRWLAEKYPLLVADVIEEEPVEIEGIKIPVDTSKPNPNNLEYDNLYLDMNGIIHPCFHPEDRPSPTTFEEVFQCMFDYIDRLFVMVRPRKLLYMAIDGVAPRAKMNQQRSRRFRSAKDASDAAAEEERLREEFEREGRRLPPKVDSQVFDSNVITPGTEFMGVLSIALQYYVHLRLNHDVGWKNIKVILSDANVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIMLGLATHEVHFSILREVVYTPGQQERCFLCGQMGHFASNCEGKPKKRAGESDEKGDGNDFVKKPYQFLHIWVLREYLELEMRIPNPPFEIDLERIVDDFIFICFFVGNDFLPHMPTLEIREGAINLLMAVYKKEFRSFDGYLTDGCKPNLKRVEQFIQAVGSFEDKIFQKRAMQHQRQAERVKRDKAGKATKRMDDEAPTVQPDLVPVARFSGSRLASAPTPSPFQSNDGRSAPHQKVRRLSPGSSVGAAIVDVENSLESDERENKEELKTKLKELIREKSDAFNSDTTEEDKVKLGQPGWRERYYEEKFSVVTPEEMERVRKDVVLKYTEGLCWVMHYYMEGVCSWQWFYPYHYAPFASDLKDLGEMDIKFELGTPFKPFNQLLGVFPAASSHALPERYRTLMTDPNSPIIDFYPTDFEVDMNGKRFSWQGIAKLPFIDERRLLEAVSEVEFTLTDEEKRRNSRMCDMLFIATSHRLAELVFSLDNHCRQLSARERVDFKVKIKPKLSDGMNGYLTPCSGETHPPVFRSPMEGMEDILTNQVICCIYRLPDAHEHITRPPPGVIFPKKTVDIGDLKPPPALWHEDNGRRPMHNNHGMHNNHGMHNNQGRQNPPGSVSGRHLGNAAHRLVSNSLQMGTDRYQTPTDVPAPGYGYNPPQYVPPIPYQHGGYMAPPGAQGYAQPAPYQNRGGYQPRGPSGRFPSEPYQSQSREGQHASRGGGYSGNHQNQHQQQQWHGQGGSEQNNPRGYNGQHHHQQGGDHDRRGRGRGSHHHHDQGGNPRHRY
Protein: Dolichol-phosphate mannosyltransferase subunit 3 (A0A1D8PLF1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365085}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365085}.
Interaction partners:
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 1
- dolichyl-phosphate beta-glucosyltransferase
- dolichol kinase
- Cwh8p
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Dol-P-Man:Man
- Mannose-1-phosphate guanyltransferase
- GPI mannosyltransferase 2
Sequence:
MTKATETGLTIFALSAIYFALITGVIPTPAKIHDEILPYLPWWGLVTFGSYALSTLGWGIVTFKDKEHKYKELKIQIEEAKDFYKTKGIDLD
Protein: DNA-binding protein reb1 (Q9P6H9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-binding protein that recognizes sites within both the enhancer and the promoter of rRNA transcription, as well as upstream of many genes transcribed by RNA polymerase II. Has a role in the termination of RNA polymerase I catalyzed transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Switch-activating protein 1
- Telomeric DNA-binding factor trf1
- DNA-directed RNA polymerase I subunit RPA12
Sequence:
MDTSVLNPELQIHGFIGVDSLQSSRKRKNDFDDFPLNKGLKTNNNDYSGSIEPKFSPALSIKEDGKNDRNFEALMSLQAQDSNLSEQNTSIHLDALASSSIALGNDNVDSSAFLSKVNKGVNAMRNSTSNQTNDSILISPSEITNMDPFLKGSARWTAEHWDYLERRMQNFCQTYSLDHTQVADSLHEKRLHGPLSSLVKLLVQEMPSFTRRTILRHLRALYNIPGYEKYSRKNSSGRGDFGVQETAIISQEVHNFIMDQGWSEYQFCNQIWAGKCPKTIRMFYSNLYKKLSHRDAKSIYHHVRRAYNPFEDRCVWSKEEDEELRKNVVEHGKCWTKIGRKMARMPNDCRDRWRDVVRFGDKLKRNAWSLEEETQLLQIVAELRNREDLSSDINWTLVAQMLGTRTRLQCRYKFQQLTKAASKFELQENVWLLERIYDSLLNNGGKIHWENIVKEANGRWTRDQMLFQFINLKKMIPSYDNLPLLEATKSAIDDFKVVLSGFSN
Protein: C-X-C motif chemokine 16 (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein) (SR-PSOX) (Small-inducible cytokine B16) (Transmembrane chemokine CXCL16) (Q9H2A7)
Organism: Homo sapiens (Human)
Function: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Also exists as a soluble form.
Interaction partners:
- C-X-C chemokine receptor type 6
- C-C chemokine receptor type 6
- C-X-C chemokine receptor type 3
- C-C chemokine receptor-like 2
- CX3C chemokine receptor 1
- C-C chemokine receptor type 5
- C-X-C chemokine receptor type 4
- C-X-C chemokine receptor type 1
- C-X-C motif chemokine 6
- C-X-C chemokine receptor type 2
Sequence:
MGRDLRPGSRVLLLLLLLLLVYLTQPGNGNEGSVTGSCYCGKRISSDSPPSVQFMNRLRKHLRAYHRCLYYTRFQLLSWSVCGGNKDPWVQELMSCLDLKECGHAYSGIVAHQKHLLPTSPPISQASEGASSDIHTPAQMLLSTLQSTQRPTLPVGSLSSDKELTRPNETTIHTAGHSLAAGPEAGENQKQPEKNAGPTARTSATVPVLCLLAIIFILTAALSYVLCKRRRGQSPQSSPDLPVHYIPVAPDSNT
Protein: Toxin ParE2 (P9WHG5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD2.
Interaction partners:
- Antitoxin ParD2
- Toxin ParE1
- Antitoxin ParD1
Sequence:
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAIDILAVRHGMENPNAVEAEISGRTFE
Protein: Mitogen-activated protein kinase 19 (AtMPK19) (MAP kinase 19) (EC 2.7.11.24) (Q9LUC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein-tyrosine-phosphatase PTP1
- Probable WRKY transcription factor 20
- Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein
Sequence:
MQKTQEKKNMKEMEFFTEYGDANRYRILEVIGKGSYGVVCAAIDTQTGEKVAIKKINDVFEHVSDALRILREVKLLRLLRHPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKVCDFGLARVSFNDTPTTVFWTDYVATRWYRAPELCGSFCSKYTPAIDIWSIGCIFAEVLTGKPLFPGKSVVHQLDLITDLLGTPKSETIAGVRNEKARKYLNEMRKKNLVPFSQKFPNADPLALRLLQRLLAFDPKDRPTAAEALADPYFKCLAKVEREPSCQPISKMEFEFERRRLTKDDIRELIYREILEYHPQLLKDYMNSEGSSFLYPSAIGHLRKQFAYLEENSGKSGPVIPPDRKHASLPRSAVHSSAVNSNAQPSLNASDSRRVSIEPSRNGVVPSTSAYSTKPLGPPPRVPSGKPGRVVESSVTYENDRNLKESSYDARTSYYRSTVLPPQTVSPNCYFLPNTMNQEKRSGTEAASQPKPQFVPTQCNSAKPAELNPNPYVQSQHKVGIDAKLLHAQSQYGPAGAAAVAVAAHRNIGAVGYGMS
Protein: FAM86 N-terminal domain-containing protein (Q384B9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Elongation factor 2
- B9 domain-containing protein 1
Sequence:
MLLPCTPHPPVSLLLFLQSAPPRKTFDAFIEDCKLCGMSWCSPAAQQLCVALIIRNPLVKKYPPRPSNIYAFLKHFIFELEQIHSGTAGAEDPDGEDPIHQDLMEAYIEYMELSGRSDQKSFCYRTYFDPNASEKYVSVRLAVGQFTNVGLALWPSAFVLVQLLARELSEPSPSVVPFPLEGELRLLELGAGVGLLPLLLKRQRAYEDRVCCCILTEYQQELVDNITFNLALQDIVVAEAVTSDTPNSGGPLHAVALLDWREHEQNQVKLRNWGCNLILAADCVYDVSLIQPFVRTLHDALSATNGCGGAVVVQTHRQRETIQRLFAVLEEAGLSVCSYRLACGVPSAGRSHDITLTFPRSVSVHTGDGSVCCFALERDEVSPSGIFKGLEGIENSVVSGWIGPFFTSMEAVVGVHVIRLRSIC
Protein: Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1) (Q8K087)
Organism: Mus musculus (Mouse)
Function: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29799787}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1 (PubMed:29799787). Internalizes efficiently in response to RARRES2 (By similarity). {ECO:0000250|UniProtKB:P46091, ECO:0000269|PubMed:29799787}.
Interaction partners:
- Retinoic acid receptor responder protein 2
- Glycoprotein hormone alpha-2
- Nicotinamide phosphoribosyltransferase
- DBF4-type zinc finger-containing protein 2 homolog
Sequence:
MEVSKEMLFEELDNYSYALDYYSQESDPEEKVYLGLVHWISLFLYALAFVLGIPGNAIVIWLMGFKWKKTVTTLWFLNLAIADFIFVLFLPLYISYVALSFHWPFGLWLCKVNSFIAQLNMFSSVFFLTVISLDRYIHLLHPGLSHRHRTLKSSLVVVILVWLLASLLGGPTLYFRDTMEVNNHIICYNNFQEHELTLMRHHVLTWVKFLFGYLFPLLTMSSCYLCLIFKMKKRNILISRKHLWMILSVVIAFLVCWTPYHLFSIWELSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLISKTFQARFRASVAEVLKRSLWEASCSGTVSEQLRSAETKSLSLLETAQ
Protein: Uncharacterized protein (Q584Y2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Large ribosomal subunit protein bL21m
- 50S ribosomal protein L17, putative
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL43
- GTP-binding protein, putative
- KOW domain-containing protein
- Acyl carrier protein
- 50S ribosomal protein L13, putative
- Large ribosomal subunit protein uL3m
- Ribosomal protein L11, putative
Sequence:
MRRIFSKSTPGCYARGVFQTTPSFRWCCFELIRESGRMRNRLCCHLPLKAARWHSSDAFTNDGTPPPLPLSNGGESDFVDLQLDDLTNALGSASARREVGDSSELGVVRENDIPEGQVFSRLNIPISSRQEEQRTNSRSALRVLASDTLEETIQQPTSTGSKQPLPYDDERFADMLLEMEVEGSLDETWQDGRKAYIEDVKEILEVLRSLKVRDICAIDVSNKTSNFDYMLFGTCEGPRHIHLAAWAVQEADALKRVCKIRRKQVDHTWEVVPVGRIIVNLMQESLREELSLERKWAVTKCMDPLSVANAPVSEGRSVKAHGLWTLTLNLQDLEDFEVDYCKDVLLTQV
Protein: Copine-3 (Copine III) (O75131)
Organism: Homo sapiens (Human)
Function: Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}. Cytoplasm {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}. Cell membrane {ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}. Cell junction {ECO:0000269|PubMed:20010870}. Cell junction, focal adhesion {ECO:0000269|PubMed:20010870}. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870, PubMed:21087455). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870). {ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}.
Interaction partners:
Sequence:
MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTGRPAGKGSITISAEEIKDNRVVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTEVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEASRSSPVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGSNGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEFPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQYFVLLIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAIRDIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLPPKNPATKQQKQ
Protein: Reticulon (Q4G5V0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}.
Interaction partners:
Sequence:
MEDTERASSAALGSAPHEESGNEASAAGKTRADEPLLDAEETRDEQVTEVTSTQQITEVNTAPQTAEVTSAEQITEVTSAEQTSLTPTTEVNTAQQTAEVTLTNVSAEQITEADPQITEQTDISLTQTTVVTSPEQVTEVTSTSPEHVTEVKADPHITEVTQITEDTSLTLPTEATSPEQVTEVRVDPQITEVTSSTQVTEETSLTQITEVTSPEQVSELKPDPQISEETLTQTAGVTSVSPEPITEITSAEQTSEETSLTQISEDVTEETSVPPVSGPPPPPPHHPAAAAPPPDRSLAPCNARPPEPCGEPHSELPPAGEPEVSVSVFQTLPSERCRSLVSSAGLAMDAFGREPSATSDPDLLSPSDDDLMLEMKSSAGLEESRSVSDSPSPDLLQDAYEDLQTPGALSAAEPPNPEQRPVALPDILQSSPLNPEKLDSGSSEGSPDCSPAHRCSPNPPLSAAGSPDSRILLLREMVEETEARAVEKVQQDVQQEVQQEAQAQLEKQVQQESQQGCTVLDLLQEAPAHTQTLPPPPQQQTDAPAELLQGLQFSSGPHVELWDSSPSADSFSPVLDAEQQKHSENTHSHTHIDAADEEQEPSSSEEFEFVERPAAGAAEEFVELQDGLTSITAPPPEAAEAPEQKQSSTCLLSPAEGGGPADGEERSDVQQTCPAGHTAGAPADPTAVLQLLYWRDVRASALVLGSLLLLLLFLSCCSVISVLSYSALCLLTLTLSTRVFTAVLQAMRKTEDGHPFRQYLERDVLLSADAVHTHSEALLRRINTALVELRRLFLVEDLVDSLKLAVGLWLLTYVGSWFNGLTLLIIALIGAFSGPIAYERHQSEIDQFISMINTQMREALGKVLAMVPGGKKKSD
Protein: Uncharacterized protein (Q584C8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRAEPNPSVGEHDPRESVSLSDRSGNIMTDCCASLLDTEWPNILGERCFTPSDEEVLSSATREQRIERGIEAPSFESLLQEIMKCYRAFCNCSGTVHFKHLEFERFLRRCLFAAHETNGLSVSSPLEGTTCKPFWLHYPPSYFLMAHDVVQSVECGTPHSSNDDSKTSSATTATLHRTPSEDLSFTGDSENEAKRREHLRQLYILSVQPVVPRTIRKKLAQCAKRESAASPGALAEAVRYMLDVYFFFIRMQFLPPFNRPTGSMYSTCVQFMTRVRGRLLTPEVAVRFTEVALVLILLSVKHQSATRCALDETTDSAVSSRLELQFLFSTYFPALVVAFLSASPLQSMEELRHSLTRTDLAECLPTLQTCRKGAELVRELFDFSQGAAPLWSVTLSEVVAFATQHLQQKDKGNEDGNSHACITSVLGVPSSVDDCLFVCDDTTLDCLLRSAPKSVQKTEEAGHERLRKEINQTFHRNQTGMSPESDEFHRKAMRVTSSSPSGPYNTLYFSLHTLANMESLSPTALSLLLTAIEKCLGPKGDLQPLCTFASSEVCTSLPVIAAELLRVVVSVLEAERSMKFMEVINEVRDLVYRGRESL
Protein: Universal stress protein Rv1636 (USP Rv1636) (P9WFC9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
Sequence:
MSAYKTVVVGTDGSDSSMRAVDRAAQIAGADAKLIIASAYLPQHEDARAADILKDESYKVTGTAPIYEILHDAKERAHNAGAKNVEERPIVGAPVDALVNLADEEKADLLVVGNVGLSTIAGRLLGSVPANVSRRAKVDVLIVHTT