wanglab/gogpt-training-data huggingface dataset:
Protein: Cadherin domain-containing protein (Q8C8Z4)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MADPPRRWICNDLLTFFMLLGTLCAPGKGQIRYSVREELDKGSFVGNISKDLGLEPRELAERGVRIISRGRSQLFSLNPRGGSLVTAGRIDREELCVQSSPCLVSFNILVENKMKIYGVEVEILDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDGDVGVNSLQGYKLSSNRHFSLDVKSGSDGQKHPELVLEQPLDREKESAHDLVLTALDGGNPVLSSTVHISVTVLDANDNAPLFTQSEYRVSVPENTPVGTRLLTLTATDADEGINAKLTFSFRNEEDKISETFQLDSNLGEISTIQSLDYEESRFYLMEVVAQDGGALLASAKVLVTVQDVNDNAPEVILTSLTSSVSEDCLPGTIIALFSVHDADSGENGEISCSIPKNLPFKLEKSVDNYYHLLTTRALDREETSDYNITVTVVDRGTPPLSTENHISLKVADINDNPPTFSRPFYSTSISENNPRGVSIFSVYAYDADSGDNAQVTYSLAENTFQEVPVSSYVSINSDTGVLYALQSFDYEHLRDLQLLVTAKDSGTPPLSSNVSMSLFVLDQNDNIPEILYPTIPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSIGLHTGEVCTARALLDRDVLKQSLVVAVQDHGQPPLSATVTLTIAVGDSIPDVLTDLGNHNTLAEPQDSDLTLYLVVSVAVVSCVFLGFVTVLLALRLRHWHMSRLLQTSTGRLADMPASHFVGMDGVQAYLQTYSHEISLTTDSKKSHLIFPQPNYADRLISEESCEKSEPLLIPHDIHTHKEEPGDAQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: Ent-copalyl diphosphate synthase 2 (IeCPS2) (EC 5.5.1.13) (G3E4M4)
Organism: Isodon eriocalyx (Plectranthus eriocalyx)
Function: Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities. Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to ent-copalyl diphosphate (ent-CPP).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSSSSNVTSLPRLTTAGGVFPREMVRVHSSCNILRSKAKVGGINYFNPGNIKCVEVHKSRQVAVAAVKSLEYETEKPTNQDVVSEKMRVLSERIGTMLQNMNEGEISISPYDTAWVALVEDTDGRPQFPTSLEWISNNQLADGSWGDRKFVIYDRILNTLACVVALTTWNMHPHKCNRGLRFIRDNIEKLENENEELMPIGFEVVFPSLIEAAQKLGIEIPHIDSPCIKKIQAMRDFKLKRIPMELLHKKPTSLLHSLEGMQGLVWEKLLDFRSDGSFLCSPSSTAYALQHTKDELCLQYLLKAVKKFNGGVPNVYPVDMFEHLWCVDRLQRLGICRYFRAQIKEMLDYVYKYWTDKGICWARNTNVQDVDDTAMGFRLLRMHGYDVSTDVFKQFEKAGEFCCFPGQSTHAITGMYNVYRTSQIMFDGEDILADAKNYSATFLHQKRLASELVDKWIITKDLPGEVGYALDVPFFASLPRLEARFFLEQYGGDDDVWIGKTLYRMPYVNSDTYLELAKLDYKKCQAVHQLEWKSIQKWYRDCKLGEFGLGEKRLLLAYFLAASTAFEPEKKGERLAWAKTAFLVETIASQQLSHEQKREFPNEFEHGSSLNMENGGRYKTRTRLVEILSNTVSQLSFETLVAEGRDIKQQLSNTWQKWLKTWEEGGNLGEAEAQLLLQTLHLSSGLDESSFSHPKYHQLLEATCKVCNQLRLFQNRKAHDAQGGISDLVIGTTFQIEASMQELVKLVFTKSSEDLDSITKQSFFAIARSFYYTAYCDAGAINSHIYKVLFENID
Protein: Magnesium transport protein CorA (P0ABI4)
Organism: Escherichia coli (strain K12)
Function: Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:780341}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WZ31}.
Interaction partners:
- Uncharacterized protein YeiB
Sequence:
MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL
Protein: ABSCISIC ACID-INSENSITIVE 5-like protein 1 (Dc3 promoter-binding factor 2) (AtDPBF2) (bZIP transcription factor 67) (AtbZIP67) (Q8RYD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Could participate in abscisic acid-regulated gene expression during seed development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15642716}.
Interaction partners:
- Nuclear transcription factor Y subunit B-6
- Nuclear transcription factor Y subunit C-2
- Nuclear transcription factor Y subunit B-9
- Serine/threonine-protein kinase SRK2A
- 12S seed storage protein CRC
- Serine/threonine-protein kinase SRK2D
- Basic leucine zipper 8
- B3 domain-containing transcription factor ABI3
- Protein DELAY OF GERMINATION 1
- Acyl-lipid omega-3 desaturase
Sequence:
MSVFESETSNFHVYNNHEIQTQPQMQTFLSEEEPVGRQNSILSLTLDEIQMKSGKSFGAMNMDEFLANLWTTVEENDNEGGGAHNDGEKPAVLPRQGSLSLPVPLCKKTVDEVWLEIQNGVQQHPPSSNSGQNSAENIRRQQTLGEITLEDFLVKAGVVQEPLKTTMRMSSSDFGYNPEFGVGLHCQNQNNYGDNRSVYSENRPFYSVLGESSSCMTGNGRSNQYLTGLDAFRIKKRIIDGPPEILMERRQRRMIKNRESAARSRARRQAYTVELELELNNLTEENTKLKEIVEENEKKRRQEIISRSKQVTKEKSGDKLRKIRRMASAGW
Protein: Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Q96PV0)
Organism: Homo sapiens (Human)
Function: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
Interaction partners:
- Disks large homolog 4
- Disks large homolog 3
- Glutamate receptor ionotropic, NMDA 2B
- SH3 and multiple ankyrin repeat domains protein 3
- Serine/threonine-protein kinase ULK2
- Disks large homolog 2
- GTPase NRas
- Disks large-associated protein 2
- SH3 and multiple ankyrin repeat domains protein 2
- Serine/threonine-protein kinase ULK1
Sequence:
MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH
Protein: Chloride channel protein CLC-d (AtCLC-d) (CBS domain-containing protein CBSCLC2) (P92943)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-gated chloride channel.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Chloride channel protein CLC-f
- Chloride channel protein CLC-e
- V-type proton ATPase subunit a1
- Sodium/hydrogen exchanger 5
- Putative DUF21 domain-containing protein At3g13070, chloroplastic
- RING-type E3 ubiquitin transferase
- Probable arabinose 5-phosphate isomerase
- Amino acid transporter AVT6E
- Sodium/hydrogen exchanger 6
Sequence:
MLSNHLQNGIESDNLLWSRVPESDDTSTDDITLLNSHRDGDGGVNSLDYEVIENYAYREEQAHRGKLYVGYYVAVKWFFSLLIGIGTGLAAVFINLSVENFAGWKFALTFAIIQKSYFAGFIVYLLINLVLVFSSAYIITQFAPAAAGSGIPEIKGYLNGIDIPGTLLFRTLIGKIFGSIGSVGGGLALGKEGPLVHTGACIASLLGQGGSTKYHLNSRWPQLFKSDRDRRDLVTCGCAAGVAAAFRAPVGGVLFALEEVTSWWRSQLMWRVFFTSAIVAVVVRTAMGWCKSGICGHFGGGGFIIWDVSDGQDDYYFKELLPMAVIGVIGGLLGALFNQLTLYMTSWRRNSLHKKGNRVKIIEACIISCITSAISFGLPLLRKCSPCPESVPDSGIECPRPPGMYGNYVNFFCKTDNEYNDLATIFFNTQDDAIRNLFSAKTMREFSAQSLLTFLAMFYTLAVVTFGTAVPAGQFVPGIMIGSTYGRLVGMFVVRFYKKLNIEEGTYALLGAASFLGGSMRMTVSLCVIMVEITNNLKLLPLIMLVLLISKAVGDAFNEGLYEVQARLKGIPLLESRPKYHMRQMIAKEACQSQKVISLPRVIRVADVASILGSNKHNGFPVIDHTRSGETLVIGLVLRSHLLVLLQSKVDFQHSPLPCDPSARNIRHSFSEFAKPVSSKGLCIEDIHLTSDDLEMYIDLAPFLNPSPYVVPEDMSLTKVYNLFRQLGLRHLFVVPRPSRVIGLITRKDLLIEENGESSAVELQQSTSVRGRYSETATRMDAARPLLDDLLG
Protein: Heat shock protein 90-6, mitochondrial (AtHSP90.6) (AtHsp90-6) (Heat shock protein 89-1) (Hsp89-1) (F4JFN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular chaperone which stabilizes unfolding protein intermediates and functions as a folding molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner.
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Protein SGT1 homolog B
- Protein SGT1 homolog A
- Peptidyl-prolyl cis-trans isomerase CYP40
- Cysteine and histidine-rich domain-containing protein RAR1
- Heat shock protein 90-5, chloroplastic
- Endoplasmin homolog
- Co-chaperone protein p23-1
- Co-chaperone protein p23-2
- Ankyrin repeat family protein
- Heat shock 70 kDa protein 4
Sequence:
MIRLSKRSVSTLLRSGNQSFRIAAAASTSRSSPSATDVKRSDTESRWYSSLTNGQSKNSGSFAQLNMKTNWFMGYRNESSAAASDSSSQAPPPAEKFEYQAEVSRLMDLIVNSLYSNKEVFLRELISNASDALDKLRYLSVTNPELSKDAPDLDIRIYADKENGIITLTDSGIGMTRQELVDCLGTIAQSGTAKFMKALKDSKDAGGDNNLIGQFGVGFYSAFLVADRVIVSTKSPKSDKQYVWEGEANSSSFTIQEDTDPQSLIPRGTRITLHLKQEAKNFADPERIQKLVKNYSQFVSFPIYTWQEKGYTKEVEVEDDPTETKKDDQDDQTEKKKKTKKVVERYWDWELTNETQPIWLRNPKEVTTAEYNEFYRKAFNEYLDPLASSHFTTEGEVEFRSILYVPPVSPSGKDDIVNQKTKNIRLYVKRVFISDDFDGELFPRYLSFVKGVVDSHDLPLNVSREILQESRIVRIMKKRLVRKAFDMILGISLSENREDYEKFWDNFGKHLKLGCIEDRENHKRIAPLLRFFSSQSENDMISLDEYVENMKPEQKAIYFIASDSITSAKNAPFLEKMLEKGLEVLYLVEPIDEVAVQSLKAYKEKDFVDISKEDLDLGDKNEEKEAAVKKEFGQTCDWIKKRLGDKVASVQISNRLSSSPCVLVSGKFGWSANMERLMKAQSTGDTISLDYMKGRRVFEINPDHSIIKNINAAYNSNPNDEDAMRAIDLMYDAALVSSGFTPDNPAELGGKIYEMMDVALSGKWSSPEVQPQQQQMAHSHDAETFEAEVVEPVEVDGKK
Protein: Siderophore iron transporter ARN2 (Triacetylfusarinine C permease) (Triacetylfusarinine C transporter 1) (P38724)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis.
Subcellular location: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Facilitator of iron transport 3
- Facilitator of iron transport 2
- Iron transport multicopper oxidase FET3
- Plasma membrane iron permease
- Iron-regulated transcriptional activator AFT1
- mRNA decay factor CTH2
- Ferric/cupric reductase transmembrane component 2
- Ferric reductase transmembrane component 5
- Facilitator of iron transport 1
Sequence:
MIEVPEDNRSSQTKRKNTEKNCNELMVDEKMDDDSSPRDEMKDKLKGTKSLIIRKSELMAKKYDTWQLKAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIAMWAFIFPLCCIPLILCMLHMRWKVRNDVEWKELQDEKSYYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGGVSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLYPKLLHYMGDADLATAAYGSPLTFILSNPWGTPVRSAMVEAYRHVQKYEVIVALVFSAPMFLLTFCVRDPRLTEDFAQKLPDREYVQTKEDDPINDWIAKRFAKALGRS
Protein: Bifunctional ATP sulfurylase/APS kinase (EC 2.7.1.25, EC 2.7.7.4) (Q9VW48)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPNPPIGFYPHIKRRCLQVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAYLVSRGIPAYGLDGDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDREMARKIHKDAGLKFYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTHGYTVRESTQKLVTLLEQEGIIPRSLRDVDLLPELYPSESIATEALRHEAESLQAIEISTVELQWVQVLAGWAYPLRGFMREDEYLQTLHFNTLQSGMDGSYRENHSVPIVLSATQADKDRLDGCSSLTLKYQGKAVAILRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRWEDGLDQYRLTPNELRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPLGGWTKDDDVPLDVRMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYIVGRDPAGMPHPAKETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRKDEFEFISGTKMRTLAKTGASPPDGFMEPEAWRILATYYQNLPQS
Protein: Myoblast city, isoform B (A0A0B4K7Q6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Ced-12
- Adapter molecule Crk
- Ras-related protein Rac1
- AT17867p
- Cdc42 homolog
- Rho guanine nucleotide exchange factor 2, isoform D
- Ras-related protein Rac2
- Rho-type guanine nucleotide exchange factor, isoform F
- Breast cancer anti-estrogen resistance protein 1
- Structural maintenance of chromosomes protein
Sequence:
MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHLCEYNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLTTNPSFPKIRRKMNELNNNRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDSVVMRRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPTASIKNFPDTRSLSESSNRNSVETTDSTSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKPRPPTPPPKPSRHSKHIP
Protein: Kelch-like 4 (Drosophila) (A5PKX1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP
Protein: mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] (O60942)
Organism: Homo sapiens (Human)
Function: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- mRNA cap guanine-N
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB1
- C-type lectin domain family 14 member A
- DNA-directed RNA polymerase II subunit RPB7
- Cap-specific mRNA
- DNA-directed RNA polymerase II subunit RPB4
- Liver carboxylesterase 1
- Nuclear cap-binding protein subunit 2
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT
Protein: Secretion system apparatus protein SsaQ (P74860)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Part of a type III secretion system.
Interaction partners:
- SPI-2 type 3 secretion system ATPase
- Secretion system apparatus protein
- Secretion system apparatus protein SsaP
- Secretion system apparatus protein SsaO
- Secretion system apparatus protein SsaT
- Virulence protein YscR
- Surface presentation of antigens protein SpaO
- SPI-2 type 3 secretion system stator protein
- Secretion system apparatus protein SsaL
- Secretion system apparatus protein SsaV
Sequence:
MLRIANEERPWVEILPTQGATIGELTLSMQQYPVQQGTLFTINYHNELGRVWIAEQCWQRWCEGLIGTANRSAIDPELLYGIAEWGLAPLLQASDATLCQNEPPTSCSNLPHQLALHIKWTVEEHEFHSIIFTWPTGFLRNIVGELSAERQQIYPAPPVVVPVYSGWCQLTLIELESIEIGMGVRIHCFGDIRLGFFAIQLPGGIYARVLLTEDNTMKFDELVQDIETLLASGSPMSKSDGTSSVELEQIPQQVLFEVGRASLEIGQLRQLKTGDVLPVGGCFAPEVTIRVNDRIIGQGELIACGNEFMVRITRWYLCKNTA
Protein: Meiosis-specific protein SPO11 (EC 5.6.2.2) (Sporulation-specific protein 11) (P23179)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The action of SPO11 is important in setting off a regulatory chain of events encompassing 5' to 3' resection. When there are no SPO11-DSBs, resection of a site specific VDE-DSB takes place but it is faster than in wild-type meiosis and increases the risk of uncovering flanking homology.
Subcellular location: Nucleus {ECO:0000269|PubMed:7926789, ECO:0000269|PubMed:9039264}. Chromosome {ECO:0000269|PubMed:9039264}.
Interaction partners:
- Meiotic recombination protein DMC1
- Antiviral protein SKI8
- Meiotic recombination protein REC8
- Meiotic recombination protein REC104
- Meiotic recombination protein REC102
- MutS protein homolog 4
- Meiosis-specific transcription factor NDT80
- Crossover junction endonuclease MUS81
- DNA endonuclease SAE2
- DNA repair protein RAD51
Sequence:
MALEGLRKKYKTRQELVKALTPKRRSIHLNSNGHSNGTPCSNADVLAHIKHFLSLAANSLEQHQQPISIVFQNKKKKGDTSSPDIHTTLDFPLNGPHLCTHQFKLKRCAILLNLLKVVMEKLPLGKNTTVRDIFYSNVELFQRQANVVQWLDVIRFNFKLSPRKSLNIIPAQKGLVYSPFPIDIYDNILTCENEPKMQKQTIFPGKPCLIPFFQDDAVIKLGTTSMCNIVIVEKEAVFTKLVNNYHKLSTNTMLITGKGFPDFLTRLFLKKLEQYCSKLISDCSIFTDADPYGISIALNYTHSNERNAYICTMANYKGIRITQVLAQNNEVHNKSIQLLSLNQRDYSLAKNLIASLTANSWDIATSPLKNVIIECQREIFFQKKAEMNEIDARIFEYK
Protein: EMILIN-2 (Basilin) (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Q8K482)
Organism: Mus musculus (Mouse)
Function: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Major component of the cochlear basilar membrane (BM) which may contribute to the developmental assembly or function of the BM.
Subcellular location: Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.
Interaction partners:
- Structural maintenance of chromosomes flexible hinge domain-containing protein 1
Sequence:
MCQETPPRPRAPSRWTPALLALLALGGAGLCHASSQPGYHARPSARNKNWCAYIVNKNVSCTVQEGSESFIQAQYNCPWNQMPCPSALVYRVNFRPRFVTRYKIVTQLEWRCCPGFRGPDCQEGPKDHMKTPRPPSARPKNNLKKATDTDPSQVSQPKKTLSPTNAVEPGQVADAKQGPPELQQSKVQVLEEKVVRLTRMVLDLQSTVVGLKENLKHTIQDDGRKEPDSWLGPLHPQPTPDSPLAGDAEPSQLPGIPSSKESGMKDIKSELAEVKDTLKTKSDKLEELDGKVKGYEGQLKQLQEAAQGPTVTMTTNELYQAYVDSKIDALREELMEGMDRKLADLKNTCEYKLVGLQQQCDDYGSSYLGVIELIGEKEASLKKDIADLRAQLQDPVAQPSCCNGQKSSDFGPQIKALDQKIERVAEATRMLNGRLDNEFDRLSVPEPDADFDARWTELDARINVTEKNAEEHCFYIEETLRGTINGEVDDLRKLLNEKIHSLEDRLGIVLQAANSSDVELTPMGPALPEQPGAENEQVLMELSRLKDKVQVVEDFCLQSLPHGIDGALPSVEDLTHVSLSLLESLNDTMHRQFQETSHSIQKLQEDVNALHSQLNHSECTGTYLQNGVSDSRTGDSMEASGFTKTGEQERTVGTVPSPGTPAAPCCGQLEERWQKLQNQMLAELDTCKESAHGVQSGVSAIEGRVFQLEQTCRRLDTISGSLQRIKEGLGKHVGSLWNCIRQMNGTLKSHSRDISGLKNSVQQFYSHVFQISTDLQDLVKFQPSATEEPSEATEGPSGKTPLESTRPSEEAPTEPPRLTPLPEDPAGPPQTGQQPVLPQRPLQPPPLPAWPGRTGLPFLPGSSGVIMETGEAGPPGRMGVSGRGLPRGVDGQMGQGPIHSSEGYAGAPGYPKSPPVTTPGVPLPTLVSFSAGLTQKPFPSDGGVVLFNKVLVNDGDVYNPNTGIFTAPYDGRYLITATLTPERDTYVEAVLSVSNASVAQLHTAGYRREFLEYHRPPGAVHTCGGPGAFHLIVHLKAGDGVNVVVTGGRLAHTDFDEMYSTFSGVFLYPFLSHL
Protein: Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) (Q96LW7)
Organism: Homo sapiens (Human)
Function: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23633586}. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23633586}; Single-pass membrane protein {ECO:0000269|PubMed:23633586}. Mitochondrion membrane {ECO:0000269|PubMed:23633586}; Single-pass membrane protein {ECO:0000269|PubMed:23633586}.
Interaction partners:
- Metaxin-2
Sequence:
MTDQTYCDRLVQDTPFLTGHGRLSEQQVDRIILQLNRYYPQILTNKEAEKFRNPKASLRVRLCDLLSHLQRSGERDCQEFYRALYIHAQPLHSRLPSRHALRKFHITNHACLVLARGGHPSLPLMAWMSSMTTQVCCSPGLASPLASAPPQRPPSGPEGRVWQAQAVQMLVSVSHFLPLPPSLSHGSFHTAWGILYVHSCPSFSNLIPRGSLHVCVDSNLVPTAAWRS
Protein: Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6) (Q9P0G3)
Organism: Homo sapiens (Human)
Function: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16456535, ECO:0000269|PubMed:17110383}.
Interaction partners:
- Serine protease inhibitor Kazal-type 6
- Sialic acid-binding Ig-like lectin 9
- Serine protease inhibitor Kazal-type 5
- Sialic acid-binding Ig-like lectin 7
Sequence:
MSLRVLGSGTWPSAPKMFLLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRDK