wanglab/gogpt-training-data huggingface dataset:
Protein: BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) (O95429)
Organism: Homo sapiens (Human)
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
Subcellular location: Cytoplasm.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 1A
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 4
- BAG family molecular chaperone regulator 2
- BAG family molecular chaperone regulator 1
- Transcriptional and immune response regulator
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- E3 ubiquitin-protein ligase CHIP
- U6 snRNA-associated Sm-like protein LSm1
- mRNA-decapping enzyme 1A
Sequence:
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
Protein: Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) (Q15369)
Organism: Homo sapiens (Human)
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
Subcellular location: Nucleus {ECO:0000305|PubMed:34700328}.
Interaction partners:
- Cullin-5
- E3 ubiquitin-protein ligase RBX1
- Core-binding factor subunit beta
- Hypoxia-inducible factor 1-alpha
- von Hippel-Lindau disease tumor suppressor
- Elongin-B
- Elongin-A
- Cullin-2
- Suppressor of cytokine signaling 2
- RING-box protein 2
Sequence:
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
Protein: 14-3-3 family protein (F4I1B7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable protein phosphatase 2C 22
- ATP synthase subunit epsilon, mitochondrial
- Dual specificity phosphatase Cdc25
- Tobamovirus multiplication protein 2B
Sequence:
MENEQSTHVHFASLSSSSERYNETFEEIKKAMKKSVQLKAELSAKERNLVSVGYKNVISARRASLEILSSIVQKEESKGNEENVKKLKNYRNKVEDELAKICNDILSVINKQLIPSSTTVDSSVLFYNMLADFSSNAESKEATDQSLDAYKRLVWYQQFQLYMTLNWTSVFLNSPESAYQLAKQAFDDAINEFDNLTEREEVIFLFPYLPPLMIDR
Protein: Plasma membrane ATPase proteolipid 1 (P32903)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane.
Interaction partners:
- Plasma membrane ATPase 1
- Plasma membrane ATPase proteolipid 2
- Putative uncharacterized protein YCL021W
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4
- Plasma membrane proteolipid 3
- Small ribosomal subunit protein uS14B
- Small ribosomal subunit protein eS32A
Sequence:
MTLPGGVILVFILVGLACIAIIATIIYRKWQARQRGLQRF
Protein: Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D) (Q6UXZ4)
Organism: Homo sapiens (Human)
Function: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:26235030}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Adhesion G protein-coupled receptor L3
- Netrin-1
- Leucine-rich repeat transmembrane protein FLRT2
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L1
- Netrin receptor DCC
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Tyrosine-protein phosphatase non-receptor type 11
- Glypican-3
Sequence:
MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL
Protein: Retina and anterior neural fold homeobox protein 2 (Q50-type retinal homeobox protein) (Retina and anterior neural fold homeobox-like protein 1) (Q96IS3)
Organism: Homo sapiens (Human)
Function: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Membrane-associated phosphatidylinositol transfer protein 3
- Retinal guanylyl cyclase 1
- Retinal-specific phospholipid-transporting ATPase ABCA4
- Aryl-hydrocarbon-interacting protein-like 1
- Cadherin-related family member 1
- X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
- Protein unc-119 homolog A
Sequence:
MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRAWPPA
Protein: Tyrosine 2,3-aminomutase (MxTAM) (EC 5.4.3.6) (Tyrosine ammonia-lyase) (EC 4.3.1.23) (B8ZV94)
Organism: Myxococcus sp. (strain Mx-B0)
Function: Has aminomutase and, to a much lesser extent, ammonia-lyase activity. Primarily, catalyzes the rearrangement of L-tyrosine to S-beta-tyrosine, which is probably incorporated into secondary metabolite myxovalargin. The aminomutase activity exclusively produces S-beta-tyrosine.
Interaction partners:
Sequence:
MDIYAVAVGRVGVELDAAQLERVRATHLRVQGWGMEKYPMYGVNTGFGELINVIIPPQFKSDLQHNLLRSHAAGGGEPFPDEVVRAIMTVRINCLMKGYSGISPEALQLLATMLNRGIHPVIPMQGSLGASGDLAPLSHMALPLIGDGHVRKNGVTRPTMEVFQEEGLTPLKLGFKEGLALVNGTSAMTGAASLALYRARHLLRLSLLASADIVQAMNASTRPFSHTGNAVKNHPGQVVIARLMRDLTEGTGLMRDHQDIMRAISERTSHSNDVEETEIYLQNAYSLRCMPQVLGVVLETLQMCQRFIEEEANSVNDNPVILDTPAETYHGANFHGQYVAMACDYLSIAVAEMGVLAERQLNRLLDPHINKPLPGFLAHAKTGLFCGFEGGQYLATSIASENLDLAAPSSIKSIPSNGQNQDIVSMGLIAARKTLALCENVGTILSVLMAALNQASHFTEAAKYSAPIRSIHEKLGKVAPRYEDERPMSTVIAQVRGVLLQEQGLALAQSLVNLDLTPDLSLEPRA
Protein: Probable thionin-2.4 (Q9C8D6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Cotton fiber protein
- Uncharacterized protein
- Jacalin-related lectin 3
- Cellulase
- Glycine-rich protein like
- Endo-1,4-beta-xylanase 1
- Probable LRR receptor-like serine/threonine-protein kinase At1g05700
- WAT1-related protein At1g09380
Sequence:
MEGKTLIVSVLIMSLFMAQNQVDANICCPSIQARTFYNACLFAVGSPSSCIRNSSCLDISESTCPRGYTNDILENTGDAVTEYCKLGCVSSVCGALTILQNSDASEIVNGEVEKCTMACSTVCTKGSMNAVENA
Protein: Flagellum site-determining protein YlxH (P40742)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the placement and assembly of flagella (By similarity). Activates the SRP-GTPase activity of FlhF.
Interaction partners:
- Flagellar biosynthesis protein FlhF
- Flagellar motor switch protein FliM
- Protein-glutamate methylesterase/protein-glutamine glutaminase
- Flagellar biosynthesis protein FlhA
- Flagellar motor switch phosphatase FliY
- Chemotaxis protein CheA
- Flagellar biosynthetic protein FlhB
- CheY-P phosphatase CheC
- Chemotaxis protein CheY
- Flagellar motor switch protein FliG
Sequence:
MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVGKSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLSVGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPFILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLSRTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREETRHKEDKQTFIEKLSSFLMRRA
Protein: Capping actin protein, gelsolin like (B8ZZL6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPA
Protein: Transmembrane protein (Q9LY44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g42440
- Protein kinase superfamily protein
- At3g62220
Sequence:
MSVVLNAGFSSPLQNRSHHVIQLKPSPFASYISLNSSRRSLLCKRRLVVSCLDTNDNSVTTTSVDSSSSSDSNKPVSESVESSNGTAKKAPLTARERLRAARVLSRYTEATPKPSKPKMGSQLLDVLKESDKKSKRKPGLPEAPTNMLDDSRRGMPKSGLTFDLPGGSDILIIAFSFVFISTVMFATTFLVWKLGAIHFNE
Protein: Putative DNA-binding protein At1g48610 (AT-hook DNA-binding motif-containing protein At1g48610) (Q94AD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May bind DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- At5g02050
- Single-stranded DNA-binding protein
- Eukaryotic translation initiation factor 4C
- Importin beta-like SAD2 homolog
- Probable galacturonosyltransferase 10
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10
Sequence:
MAKTALTPPASGSEVPRSGTPGDASGNKPQTDATGVSATDTASQKRGRGRPPKAKSDSSQIGAVSAKASTKPSGRPKRNVAQAVPSTSVAAAVKKRGRAKRSTVTAAVVTTATGEGSRKRGRPKKDDVAAATVPAETVVAPAKRRGRKPTVEVAAQPVRRTRKSTSVAPVAANVGDLKKRTALLQKKVKEAAAKLKQAVTAIDEVQKLADGM
Protein: Zinc/iron regulated transporter-related protein 42C.2 (A1Z6P0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- IP18018p
- LD23375p
- Zinc transporter 63C, isoform F
- FI23527p1
- RE54080p
- Zinc transporter 33D, isoform B
- Zinc transporter ZIP11
- Zinc/iron regulated transporter-related protein 102B, isoform E
- LD05335p
- Zinc transporter ZIP13 homolog
Sequence:
MVDQHLIVAKIVAIVVLFLVTLIFCFIPYLLDRFYKWTQRPENNAREFKVVLCLLNFGGGVLIATTFIHMLPEVVEVVNALQDCRMLAPTPFGLPEVLLCTGFYLMYCIEETMHFVVRRRQQRKLREVVTIKDAGEELRTEIVVQPEESPKEPNWLRGLGIIVALSLHELFGGMAIGLEMSVSTVWFMTGAISVHKLVLAFCIGMEIMMAHTRWLLAVVYLLVFSIVTPIGVGIGIAVSESAAANQPSTVSGILQGLACGTLIYVVFFEIVAKNHAGIRILLSSMVGFVLMFGLQIAIGEAKGKSHFTCP
Protein: RAB7, member RAS oncogene family (RAB7a, member RAS oncogene family) (Rab7 protein) (Ras-related protein Rab-7a (EC 3.6.5.2)) (Q7T2C6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Late endosome membrane {ECO:0000256|ARBA:ARBA00004414}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}.
Interaction partners:
- RILP-like protein 2
- TBC1 domain family, member 15.
- FYVE and coiled-coil domain autophagy adaptor 1a.
- Rab proteins geranylgeranyltransferase component A
- Dynein, cytoplasmic 1, heavy chain 1.
- Dynein light intermediate chain
- Dynein light intermediate chain
- Vacuolar fusion protein CCZ1 homolog
- Dynein cytoplasmic 2 heavy chain 1.
- Dynein, cytoplasmic 1, intermediate chain 2a
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDRNDRAKPSAETCSC
Protein: GPI ethanolamine phosphate transferase 3 (Q385R1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- GPI-anchor transamidase subunit 8
- GPI mannosyltransferase 3
- GPI transamidase component GAA1
Sequence:
MTSRSDAGVFHVRALLLGVLYVCGSLLFVTSMLSKTTTLTNVSSNTCPTVRGVDQIIVLLVDALRPDFVLPALSPHYLDGVECSTVSARGVDGNVNGDRRSTLTYMEENLKRVAHPSHGFFFLSDTPTITAQRIKAITTGTTPAFLEVGTNLNTDEVQIDNILLQLRRRSILLGDDTWLNLFPDHQGNASFWKHTHALPPYNVSDFDTNDATVIADLMPLLLSETAEQAPDDYARLIIGHLLAVDHVGHRHHASHPAMYKKLSDINEMLRNVTKRLREERQTSMRTLLVVFGDHGMTNSGDHGGDSEGERDSFMYAELFESSRDSVHAPVNSSDKFQRKNNLTEKRWEDNIDEDLSRLKACRDVAGVHPGKLSAVHQVDLTPTLALLLGVPIPFSNVGRVIPEMVALSNPDVNMSASEECNWKQLTSYFDEAGLYIKPEWKDSNLSLRRRIAQMSHFARSIRMEIRRDGAFIGSSLCMVTALSLLRNGDIQQVICGRSVLGIGTLFLLVLRLLAVFANSFIIKESVEVFCLLQLLLIAALFVAPTKGGGRHASFLIVILLVLLRVAVPLVSRERSHITHTAEATSHLEMWLAKQFPEFHYNSVGIILGAALFVFSAPTMPHRLMGIVLGTVAAVCYGQPLIHHIGPFVFFALTFFFRGMGPLRYTALVLWSSSLCNDNYVASASIAVSGVLLPVVLTATRHLPVVPQALMLHLYMWVSFFAQGNQCLLNTVDLNASFVGLPFNSVALGSVFVLSRLCNAFLFAPIAVMITYGTDRARGWRVCYLLLYITLAQSAVSSFNGYIQKSHLMFFPIFCPKFIFDFCIGMAACIGYALAALLA
Protein: Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD antigen CD137) (P20334)
Organism: Mus musculus (Mouse)
Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Subcellular location: Cell membrane; Single-pass type I membrane protein {ECO:0000305|PubMed:7678621}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 9
- Tumor necrosis factor ligand superfamily member 4
- T-cell surface glycoprotein CD3 zeta chain
- CD70 antigen
- TNF receptor-associated factor 1
- Tumor necrosis factor receptor superfamily member 4
- T-lymphocyte activation antigen CD80
- Inducible T-cell costimulator
- Galectin-9
- CD276 antigen
Sequence:
MGNNCYNVVVIVLLLVGCEKVGAVQNSCDNCQPGTFCRKYNPVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRCEKDCRPGQELTKQGCKTCSLGTFNDQNGTGVCRPWTNCSLDGRSVLKTGTTEKDVVCGPPVVSFSPSTTISVTPEGGPGGHSLQVLTLFLALTSALLLALIFITLLFSVLKWIRKKFPHIFKQPFKKTTGAAQEEDACSCRCPQEEEGGGGGYEL
Protein: Fungal lipase-type domain-containing protein (Q38D50)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Peptidyl-prolyl cis-trans isomerase
- Uncharacterized protein
- 50S ribosomal protein L13, putative
- Uncharacterized protein
- Uncharacterized protein
- Large ribosomal subunit protein uL4m
- Uncharacterized protein
- Uncharacterized protein
- Tetratricopeptide repeat
Sequence:
MSVPSAIRIDTRVAYRRLIKVAEQVTRDCPLYQTEGLRQYVGRRFLERAERNRQQYRHLLHDGSGDARGGRRKSQKQRVLTAQYGKFIAKELQQVHGLAELLLRAPGNTALTSMLQVLSAGVGNVHYQQTVERNYVRYCQFEEKKLDRDEVEEEATSDRQNRIMQHALIPYGERLLILHRLQETGGGRDAVAEPGRLTSWQVTEAIVGTRSGVTAHHMSHGKENVVVEVDETFNKQIVYVRCETYDWSRDVERVEIAEAEELRGTVFHAEYLSVALRLCDALMVETPLHAYRSTVLVGHGVGGAVAFCLALLLHARGFDVKNCVTLGAPKCIQKSLARYVHAVNPIRVVLEGDPLIELPVTGAEGDPFVHCGEILLMDNRARADLGSEADMKTREAGRQSEGGRNESTEDLFTAESLSDSLDASEEPAMGNEEGCVATGDYNDEGDVGGEDLLEQLRLAAKRYSEGFLVNHYVEHLTDTTVRLTYAEGDEVWDEGDYAQMKREDQLGHSFSGSQKWQDELRSPV
Protein: Laccase-3 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 3) (Diphenol oxidase 3) (Urishiol oxidase 3) (Q56YT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lignin degradation and detoxification of lignin-derived products.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Phenylalanine ammonia-lyase 1
- Phenylalanine ammonia-lyase 4
- Probable caffeoyl-CoA O-methyltransferase At4g26220
- Phenylalanine ammonia-lyase 3
- Phenylalanine ammonia-lyase 2
- Basic blue protein
- Cinnamoyl-CoA reductase 2
- Cinnamoyl-CoA reductase 1
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Trans-cinnamate 4-monooxygenase
Sequence:
MESFRRFSLLSFIALLAYFAFLASAEHHVHQFVITPTPVKRLCRTHQSITVNGQYPGPTLVVRNGDSLAITVINRARYNISIHWHGIRQLRNPWADGPEYITQCPIRPGQTYTYRFKIEDQEGTLWWHAHSRWLRATVYGALIIYPRLGSPYPFSMPKRDIPILLGEWWDRNPMDVLKQAQFTGAAANVSDAYTINGQPGDLYRCSRAGTIRFPIFPGETVQLRVINAGMNQELFFSVANHQFTVVETDSAYTKPFTTNVIMIGPGQTTNVLLTANQRPGRYYMAARAYNSANAPFDNTTTTAILQYVNAPTRRGRGRGQIAPVFPVLPGFNDTATATAFTNRLRYWKRAPVPQQVDENLFFTVGLGLINCANPNSPRCQGPNGTRFAASMNNMSFVLPRSNSVMQAYYQGTPGIFTTDFPPVPPVQFDYTGNVSRGLWQPIKGTKAYKLKYKSNVQIVLQDTSIVTPENHPMHLHGYQFYVVGSGFGNFNPRTDPARFNLFDPPERNTIGTPPGGWVAIRFVADNPGAWFMHCHIDSHLGWGLAMVFLVENGRGQLQSVQAPPLDLPRC
Protein: Cyclin-dependent kinases regulatory subunit 2 (CKS-2) (P56390)
Organism: Mus musculus (Mouse)
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Interaction partners:
- Cyclin-dependent kinase 1
- S-phase kinase-associated protein 2
- Cyclin-dependent kinases regulatory subunit 1
- S-phase kinase-associated protein 1
- Cyclin-A2
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
- Cyclin-dependent kinases regulatory subunit
- G2/mitotic-specific cyclin-B2
- Cyclin-dependent kinase 2
Sequence:
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK
Protein: Kelch-like protein 22 (Q99JN2)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (By similarity). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q53GT1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q53GT1}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q53GT1}. Nucleus {ECO:0000250|UniProtKB:Q53GT1}. Lysosome {ECO:0000250|UniProtKB:Q53GT1}. Note=Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase. Localizes to the nucleus upon amino acid starvation. Relocalizes to the cytosol and associates with lysosomes when amino acids are available. {ECO:0000250|UniProtKB:Q53GT1}.
Interaction partners:
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- GATOR1 complex protein DEPDC5
- Kelch-like protein 21
- Kelch-like protein 13
- Kelch-like protein 9
- Leucine-zipper-like transcriptional regulator 1
- E3 ubiquitin-protein ligase ARIH1
- Kelch-like protein 3
- Kelch-like protein 12
Sequence:
MAEEQDFAQLCRLPTQPSHSHCVNNTYRSTQHSQALLRGLLALRDSGILFDVVLVVEGKHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLADLFDLNHLTQQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLNEPPKLLETVRFPLMEAEVLQRLHDKLGPSPLRDTVASALMYHRNEILQPSLQGPQTELRSDFQCVVGFGGIHSTPSTILSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCVVGKYIYAVAGRDYHNDLSAVERYDPATNSWDYVAPLKKEVYAHAGTTLQGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAALLDKLFVIGGSNNDAGYRRDVHQVACYSCTSRQWSSVCPLPAGHGEPGIAVLDSRIYVLGGRSHNRGSRTGYVHIYDMEKDCWEEGPQLNNSISGLAACVLTLPRSLLHEQPRGTPNRSQADADFASEVMSVSDWEEFDNSSED
Protein: F-box protein PP2-B11 (Protein PHLOEM PROTEIN 2-LIKE B11) (AtPP2-B11) (SKP1-interacting partner 12) (Q949S5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase SRK2I
- WD40 repeat-containing protein HOS15
- RING-H2 finger protein ATL22
- FBD-associated F-box protein At4g13985
- RING-H2 finger protein ATL46
Sequence:
MNNLPEDCIAKILSLTTPLDVCRLSAVSSIFRSAAGSDDVWNHFLPADFPAGFAAPAGLPTRKQLFFSLVDNPLLINGTLLSFSLERKSGNKCYMMAARALNIVWGHEQRYWHWISLPNTRFGEVAELIMVWWLEITGKINITLLSDDTLYAAYFVFKWNHSPYGFRQPVETSLVLADTESTDNVVQPSMISLMQDSGGEEGQSPVLRRDGWYEVELGQFFKRRGDLGEIEMSLKETKGPYEKKGLIVYGIEIRPVP
Protein: Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) (Q9CQQ4)
Organism: Mus musculus (Mouse)
Function: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity).
Subcellular location: Nucleus, gem {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm (By similarity). {ECO:0000250}.
Interaction partners:
- Serine-threonine kinase receptor-associated protein
- Probable ATP-dependent RNA helicase DDX20
- Gem-associated protein 5
- Gem-associated protein 7
- Gem
- Survival motor neuron protein
- Gem-associated protein 8
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNISLSGCQPAPEGYSPTLQWQQQQVAHFSTVRQSVHKHRNHWKSQQLDSNVAMPKSEDEEGWKKFCLGERLCAEGATGPSTEESPGIDYVQVGFPPLLSIVSRMNQTTITSVLEYLSNWFGERDFTPELGRWFYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVGSKDDERVPALNLLICLVSRYFDQRDLADEPS