wanglab/gogpt-training-data huggingface dataset:
Protein: RE03646p (Q8MQP8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
SVVPNMLEEAKSLPLHCVVESVHSLHASLTIDTRQPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPLEQISDNPAVPVSDIVGELTSVITLRIVILRPKTSPFGEIKDKLLKLLVLQSHAVLRSTGCPLDEVTLSQICRSSHQNTYALPGGEISDELRRKFDQWWSNQLSPQATAMTPKMLPFMTGPSAVPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLANEAAHHAGAGQAPGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPNQKTRMRTSFDPEMELPKLQKWFADNPHPSRQQIQTYVVQLNALESRRGRKPLDVNNVVYWFKNARAAQKRAEMRGGSLGSAISALGHATMNGYLSQHAPLGQNSSSSAGSQPMSMGNLSMSHDYLKSPLSLKSEDIDTMSQHSDDMDEEQSRPNTPQLPLSLTTHERHRSSPLMDEDEDEAGEQQQPQEAKSDGMNGSVKDEERQEKSRDELQDNEKENSNGEDRHLDADAQMEASSNLNNNHNNSSLHIEQEVGSTPKRSTPKEEDDDLDMDEDEEDNENDASHLDEFRSPSPDLAGGVVPHKDQLPFPMVPNSMFSQSFMYMSHYIPVFGQAAAGHPHHHAAAAAAAAGIQPNALMGGGGLNLSSISNEERRKRNRTFIDPVTEVPKLEQWFAMNTHPSHNLILKYTEDLNTMPYRQKFPRLESKNVQFWFKNRRAKCKRLKMSLYDSNQCAQLGGLGSFVPKYEERD
Protein: AarF domain-containing protein kinase 1 (EC 2.7.-.-) (Q86TW2)
Organism: Homo sapiens (Human)
Function: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:33988507}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Sequence:
MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKSWPVFLQVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL
Protein: Zinc finger protein 419 (Q96HQ0)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAAAALRDPAQVPVAADLLTDHEEGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGLASSKTHEITQLESWEEPFMPAWEVVTSAIPRGCWHGAEAEEAPEQIASVGLLSSNIQQHQKQHCGEKPLKRQEGRVPVLRSCKVHLSEKSLQSREVGKALLISSGVLKHQVTHTGEKSHRSSKSREAFHAGKRHYKCSECGKAFGQKYLLVQHQRLHAGKKTYECSECGKLFRDMSNLFIHQIVHTGERPYGCSNCGKSFSRNAHLIEHQRVHTGEKPFTCSECGKAFRHNSTLVQHHKIHTGVRPYECSECGKLFSFNSSLMKHQRIHTGERPYKCSECGKFYSHKSNLIKHWRVHTGERPYKCSDCGKFFTQCSSLMQHQKVHTGEKPFKCNECGRFFRENSTLVRHQRVHTGAKPYECRECGKFFSQSSTLMQHRKVHIGEKPFKCNECGRLFRENSSLVKHQRVHTGAKPYECRECGKFFRHNSSLFKHRRIHTGEMQ
Protein: Angiomotin (A0A0G2JX94)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
- Rho GTPase-activating protein 17
- InaD-like protein
- Protein PALS1
- Merlin
- Transcriptional coactivator YAP1
- WW domain containing transcription regulator 1
- Multiple PDZ domain protein
- Plasminogen
- non-specific serine/threonine protein kinase
- Angiomotin-like protein 2
Sequence:
MRNSEDQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGNSSPFSTGSGNPVPQNDVLSSQDHHQQLVAHPARQEPQGQEIQSENGVMEKQVSPRMQNNEELPTYEEAKVQSQYFRGQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLTPGKMHQDEGLRDLKQGHVRSLSERLMQMSLATSGVKAHPPVTSAPLSPPQPNDLYKNPTSSSEFYKAQGPPPSQHSLKSMEHRGPPPEYPFKGVPSQSVVCKSQEPGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARATQDIASLSFSARNSQPHSPTSSLTAGAASLPLLQSPPSTRLSSGQHGLVSNQGDHSAHLPRHQQHLLPNQSHQGDHYRHPQPSLTPAQQQPGEAYSAMPRAQQAAAYQPMPADPFAIVSRAQQMVEILSDENRNLRQELDGCYEKVARLQKVETEIQRVSEAYETLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRDRLETANKQLAEKEYEGSEDTRKTISQLFAKHKENQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNSQPTNASEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSSMRPAKSLMSISNAGSGLLVHSSTLTGVPIMEEKRDDKSWKGSLGILLGGDYRAEPVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGSESTKTAAVTPISVPMAGPVAAAAPAAAINATAATNTATAATNTTIMVAAAPVAVAAAAAPAAATATPSPANAAALAAAAAAAVTPATPVSAATSVSAATSISQAAPVSPAAPVSPAAPVSPAAAGQIAVAASLTSATVSPTPAAATAAGAAAGAGAGAGAGAAAGAAVATVAAAATTTAIQVAPATSAPVPSPASIPAPATAQASAPTPTQASTPAPIEPPTAVPTPTPALVQAEGPASPGASSGPRRLSTPNLMCNPDKPDGPAFHSSTLERKTPIQILGQEPDAEMVEYLI
Protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) (Q9ULH1)
Organism: Homo sapiens (Human)
Function: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:25673879}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:25673879}. Note=Predominantly cytoplasmic. Partially membrane-associated. Localized to the Golgi, TGN and rhodopsin transport carriers (RTC) when interacting with RHO in photoreceptors (PubMed:25673879). Localized to RTC when interacting with RAB11A and RAB11FIP3 in photoreceptors (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:25673879}.
Interaction partners:
- ADP-ribosylation factor 6
- Proto-oncogene tyrosine-protein kinase Src
- ADP-ribosylation factor 4
- NF-kappa-B essential modulator
- Adenomatous polyposis coli protein
- Src substrate cortactin
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
- ADP-ribosylation factor 1
- Rab11 family-interacting protein 3
- Ras-related protein Rab-11A
Sequence:
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Protein: Homolog of Odr-2 (Two) (Ly-6-related protein ODR-2 isoform 2b) (Q9BMI0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHLPLSSLHPMGLLFRLLLFWNTIVLAARERSNTEYWKDQHPQQRWRIYSLRLPCYSCMSPYLEDHYPYISHLYRKPLSFDTHCDKHSLETSYLYSKNCSDMCVTLRINDVVGGRRRHGYMRGCLSDLHGYNHSLIRTLAERQGCLDTTARELFLPTAQRQELEPSRLSLCACHNNLCNFSVSPPCFFIFLFVILVIFLMR
Protein: Uncharacterized mitochondrial carrier C1682.09c (O74439)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- ADIPOR-like receptor SPBC12C2.09c
- Mitochondrial import inner membrane translocase subunit tim10
- ADP,ATP carrier protein
- Zinc-regulated transporter 1
Sequence:
MAPVQLKNKESQTARIVGSASAGILELSLFHPVDTISKRLMSNHGKITSLTQLNTVIFRDAASAPLLQKATSLFPGLGYAACYKIVQRIYKYSGQPIVKDFLNENYRHTFDKTFGKGSGKAIMHATAGSIVGIGEIFLLPLDVLKIKRQTNPAAFKGRGVFRILADEKFALYRGWGWTAARNAPGSFALFGGNAFAKEYIFKLKDYSQATFFQNFFTSIAGASASLIVSAPLDVIKTRIQNKNFDNPQSGFTILKNMLKFEGPTSFFKGLTPKLLTTGPKLVFSFTMAQTLIPFFDKLLK
Protein: Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) (Q92934)
Organism: Homo sapiens (Human)
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Subcellular location: Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- RAC-alpha serine/threonine-protein kinase
- 14-3-3 protein zeta/delta
- RAF proto-oncogene serine/threonine-protein kinase
- 14-3-3 protein theta
- 14-3-3 protein beta/alpha
- 14-3-3 protein epsilon
- 14-3-3 protein eta
- cAMP-dependent protein kinase catalytic subunit alpha
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
Protein: 1-cys peroxiredoxin (EC 1.11.1.15) (Q8IAM2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Glutathione peroxidase
- Glutathione reductase
- Glutathione S-transferase
- Glutathione synthetase
- Thioredoxin-like protein
- Peroxiredoxin
- NADH-cytochrome b5 reductase, putative
- DnaJ protein, putative
Sequence:
MAYHLGATFPNFTATASNVDGVFDFYKYVGDNWAILFSHPHDFTPVCTTELAEFGKMHEEFLKLNCKLIGFSCNSKESHDQWIEDIKFYGNLDKWDIPMVCDESRELANQLKIMDEKEKDIKGLPLTCRCVFFISPDKKVKATVLYPATTGRNSQEILRVLKSLQLTNTHPVATPVNWKEGDKCCILPSVDNADLPKLFKNEVKKLDVPSQKAYLRFVQM
Protein: Uncharacterized protein YIL055C (P40523)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MTLEPHYSAKSAASASAFVARSATESSTASTKAAPRKKTYSQSNGIPIRIDNLPPGKTWAQVKYLIGGIIYHTNILQVKMLPPMTSMVPPFITFQSCIVILKNSIDNESLENLLLTLNTYQWDYHDLFVYLLPYTNDSPSLRYPEISDSNNDVRSAPDETKRSISPRYASHVSSVTPQPPSASTPPSQFFSFSPEVSLRKNENITPLPTPVPVPVGVPPLAPPPHGPFSTSMLPMLGAPPGTVPNMQMPYQTTLPSPTAAATAGGPLASPTHYPRRRHFYHQNQSQFQKYMHNSPRNPDTGTGPRLSQQHHLSLRNNKINPSYNEISALYNLNMASNSNNNGNIPTTSTNGDDRALQAKNGGTITPSQTQINHKRLKHIFNEKSFRKQMTNRGMWQLKIINFPPYIPIEFLEKLSESDFNELMNQEKFTVIEIKEKGQLEKFGRLRWTVLKDFIKLKCPKLLRLQERQFLQQQNEASLLNESMDALKISENENTNGSANNSTYTNGGPRTSINNTREFYVGVYEDHEEATLLRFELPEDELEEFNRNLPTTFAQSGNVSDSEGDSKAKYFKVSTIVYNAIVGFHDKELSDLTFESLQDQEYSLGYKIHVMELPPFDEDEFENQRQQF
Protein: Cyclic dof factor 5 (Dof zinc finger protein DOF1.10) (AtDOF1.10) (H-protein promoter-binding factor 2b) (Q9SEZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity). Regulates a photoperiodic flowering response. Transcriptional repressor of 'CONSTANS' expression.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Adagio protein 3
- Two-component response regulator-like APRR9
- Protein LHY
- Protein CCA1
- K-box region and MADS-box transcription factor family protein
- Protein GIGANTEA
- Two-component response regulator-like APRR7
- Two-component response regulator-like APRR5
Sequence:
MSKSRDTEIKLFGRTITSLLDVNCYDPSSLSPVHDVSSDPSKEDSSSSSSSCSPTIGPIRVPVKKSEQESNKFKDPYILSDLNEPPKAVSEISSPRSSKNNCDQQSEITTTTTTSTTSGEKSTALKKPDKLIPCPRCESANTKFCYYNNYNVNQPRYFCRNCQRYWTAGGSMRNVPVGSGRRKNKGWPSSNHYLQVTSEDCDNNNSGTILSFGSSESSVTETGKHQSGDTAKISADSVSQENKSYQGFLPPQVMLPNNSSPWPYQWSPTGPNASFYPVPFYWGCTVPIYPTSETSSCLGKRSRDQTEGRINDTNTTITTTRARLVSESLRMNIEASKSAVWSKLPTKPEKKTQGFSLFNGFDTKGNSNRSSLVSETSHSLQANPAAMSRAMNFRESMQQ
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Ubiquitin thioesterase) (P35122)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- GH17761p
- Polyubiquitin
- Ubiquitin-like protein NEDD8
- 26S proteasome non-ATPase regulatory subunit 14
- Nedd8-activating enzyme E1 catalytic subunit
- Ubiquitin-like domain-containing protein
- Proteasome subunit beta
- Proteasome subunit alpha type-2
Sequence:
MLTWTPLESNPEVLTKYIHKLGVSPAWSVTDVIGLEDDTLEWIPRPVKAFILLFPCSETYEKHRAEEHDRIKEVEEQHPEDLFYMRQFTHNACGTVALIHSVANNKEVDIDRGVLKDFLEKTASLSPEERGRALEKDEKFTADHEALAQEGQTNAANHEKVIHHFIALVNKEGTLYELDGRKSFPIKHGPTSEETFVKDAAKVCKEFMARDPNEVRFTVLALTAAQQ
Protein: Uncharacterized protein (Q9NAC0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
METEICEQLGDLHLDKEAILLRAEQIEQDIKARKYSVIPPLSDEEQNLLDAEIAKRAAPPPGVPDAADFPLHDIVKELGLDKPVDGTDPEFYEELKAKDANTVYKNMKDVPDSIAAKYLPDLARRFVEFERRVKRVERMLWALPREDRSLEEDRFEILTELLDKSCQGLEIWEEHCERKIPLGHRCVLEGELIHLITSKFDLIDKICGEFDKLKNKRSEVNDERDMLRYEIRHCDMIFTEIHEKFLKSYLEMDW
Protein: Cytochrome c-552 (EC 1.7.2.2) (Ammonia-forming cytochrome c nitrite reductase) (Cytochrome c nitrite reductase) (Q9S1E5)
Organism: Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / CCUG 13145 / JCM 31913 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Function: Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process. Has very low activity toward hydroxylamine, and even lower activity toward sulfite. Sulfite reductase activity is maximal at neutral pH.
Subcellular location: Periplasm {ECO:0000269|PubMed:10672190, ECO:0000305|PubMed:10984487, ECO:0000305|PubMed:12296741}.
Interaction partners:
- Cytochrome c-type protein NrfH
- Periplasmic nitrate reductase
- Periplasmic nitrate reductase, electron transfer subunit
- NRFJ
- Hydroxylamine reductase
- Protein NrfI
- Nitrogenase iron protein
- Glutamine synthetase
- Glutamate dehydrogenase
- Nitrogenase molybdenum-iron protein beta chain
Sequence:
MTKFKLLLAGSLVAIVSMGLLASNINEREKERVALNKTAHSQGIEGKAMSEEWARYYPRQFDSWKKTKESDNITDMLKEKPALVVAWAGYPFSKDYNAPRGHYYALQDNINTLRTGAPVDGKTGPLPSACWTCKSPDVPRIIEQDGELEYFTGKWAKYGDEIVNTIGCYNCHDDKSAELKSKVPYLDRGLSAAGFKTFAESTHQEKRSLVCAQCHVEYYFKKTEWKDDKGVDKTAMVVTLPWSKGISTEQMEAYYDEINFADWTHGISKTPMLKAQHPDWELYKTGIHGQKGVSCADCHMPYTQEGAVKYSDHKVGNPLDNMDKSCMNCHRESEQKLKDIVKQKFERKEFLQDIAFDNIGKAHLETGKAMELGATDAELKEIRTHIRHAQWRADMAIAGHGSFFHAPEEVLRLLASGNEEAQKARIKLVKVLAKYGAIDYVAPDFETKEKAQKLAKVDMEAFIAEKLKFKQTLEQEWKKQAIAKGRLNPESLKGVDEKSSYYDKTKK
Protein: C2 calcium dependent domain containing 5 (H0YGU7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XQQTQSALEQRGGSPHRFCRRREFPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPAFVGIMGNTRSYKLLDWNSFNSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCY
Protein: DnaJ and Myb-like DNA-binding domain-containing protein (F4J6A8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g72040
- Putative pentatricopeptide repeat-containing protein At3g11460, mitochondrial
- Cysteine/Histidine-rich C1 domain family protein
- Hypoxia-responsive family protein
- Acetamidase/Formamidase family protein
- Acetamidase/Formamidase family protein
- Embryo-specific protein ATS3B
- Ran-binding protein 1 homolog c
- Mediator-associated protein 2
Sequence:
MPSRRSESAIRLITYSEELVDGKPFFAFSNCLPVKALNREPAGHAFHSAALKLHGCAEEPTDDEGGDKKVGDDKEKEYVPSFNSYANKGKKKSGTQQQDHYALLGLSNLRYLATEDQIRKSYREAALKHHPDKLASLLLLEETEEAKEAKKDEIESRFKAIQEAYEVLMDPTRRRIFDSTDEFDDEVPSDCLPQDFFKVFGPAFKRNARWSVNQRIPDLGDENTPLKDVDKFYNFWYAFKSWREFPDEEEHDLEQADSREERRWMEKENAKKTVKARKEEHARIRTLVDNAYRKDPRIVKRKEEEKAEKQQKKDAKIQAKKKQEEDAAIAAEEEKRRKEEEEKRAAESAQQQKKTKEREKKLLRKERNRLRTLSAPLVAQRLLDISEEDIENLCMSLNTEQLQNLCDKMGNKEGLELAKVIKDGCNSSRNDEAESKEKVSKKTNGGTEPTTRVSQLDSSTQKKQPWSKEEIDMLRKGMIKYPKGTSRRWEVISEYIGTGRSVEEILKATKTVLLQKPDSAKAFDSFLEKRKPSASITSPLSTREELGESLPTMTTTTNAKPSKETVVGKSSSSQSSDNNGEVGGSSDADSWSTVQERALVQALKTFPKETSQRWERVAAAVPGKTMNQCKKKFAELKEIIRNKKTGV
Protein: Histidine protein kinase SLN1 (EC 2.7.13.3) (Q5A872)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphorelay intermediate protein YPD1
- High osmolarity signaling protein SHO1
- Mitogen-activated protein kinase HOG1
- MAP kinase kinase kinase
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase kinase
- Ste50p
- Serine/threonine-protein kinase CST20
- Opy2p
Sequence:
MRRLKIGIRPQLIIIVCFASLFSLLILGIVTGIYFSANLKNLRLERLLVISQLKRTQVQQAIQYIAYQVMTVSEVDSLTVPLSNYRAGNNSKAVFSEAQNYLQQYVLTTDSFTAARLYDLDLQVVASSFDNMTLISESAQDVVYPLQPNRSMPPVLGTPSGLYFTGPIANNSDNFNSRYFMGITVPVLSNSSIILSQPSISGYLTIVAAAESIRSALNSTSEDDYQAMAVQPVYGDPQKGIDNLSQNAYNGDNEVIGFKLVFPVENSLLEAGTIYNINSSSSMKTALASNSGTATGVKSFFGKKVAIGFSRISVQDNLNWSIVIVQSNSVFNGPANKLRKITIGVVIGIGAFMCFVTFPLAVWFIRPITKLKEATEAITKYKKEKLNSVNSNSPTSGSGSGSGSGSGSRANSDSSADQSLSLDTGKRNSINSSSFSSSYSTGIRLPARIPRSKKIFKDELTELSEAFNIMTEELDKQYTHLEDRVKLRTKELEASKIQAEAANEAKTVFIANISHELRTPLNGILGMTSIAMEEEDPNVIHDSLKLIHRSGELLLHILTELLTYSKNTLNRSKLEKSNFQILEIVYQVRSIFNKLAHDQRVNFKILVKPNIFRKLIIYGDSNRIIQIVMNLVSNSLKFTPVDGSVSVSFKLLGEYDHERSKKLDYKKVCILNDSSSSTVAVPPPTPPSDTKPNPKPKSTPTPKPDPTRSHLVDHNNRSANTTSPLTPVRKPTNQTKNKSITNNVTKQNMKIRKKKKTNKNLHNNNNNNKNDNSDFLMNRRLSGSHKFNNTNDEELSPTAIEKNIDKYLTSSADSDNISVTTLSTVQYETTIFESQFKSKPLPALPVDAKPQVSGKIDENDVNDEDPSGGSIKDDDSEDTINEKQGISSSPSSSSSSNEKQENSPRSNDSTTVTVTRPRHNMMPSAQDFKSYPTFDKKPEYDSNMSNNEIVKNNRVYRIRNMYQPKVWVIQIEVTDTGPGIEPALQEKVFEPFVQGDQTLSRSYGGTGLGLSICRQLATMMHGTLTLKSTIGKGSTFTLTLPLPQTGEIMVPPEDMAEFCEDEFNPAAKINRKVAFEDGDIDTESQQQENPSSEEDTQGDRNVQSSTSSSPPNSSSTDSALPASDSSDIGGTNKSKTTSHGNNKNINAKKRIITNSSASSTKGTKRHTNNDGGGGVNGNHSDDNKDLTLTIDKPSLFTRGSTGTANSGTTSSHSDKKILYPTPTTTTTTTTTTDHTTVLDDISHLRVLVAEDNSVNQEVISRMLKQEGITNLTMACNGAKAIDFVKESIENNENFDLIFMDVQMPEVDGLKATKMIRKNLQYNKPIIALTAFADESNVKECLNSGMSGFITKPISKTNIKKVLVEFLSNEVVTS
Protein: Lipopolysaccharide glucosyltransferase WaaG (EC 2.4.1.-) (Lipopolysaccharide glucosyltransferase I) (UDP-glucose:(heptosyl)lipopolysaccharide glucosyltransferase) (P25740)
Organism: Escherichia coli (strain K12)
Function: Involved in the addition of the first glucose residue to the lipopolysaccharide core.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:26244737, ECO:0000305|PubMed:29225173}; Peripheral membrane protein {ECO:0000269|PubMed:29225173}; Cytoplasmic side {ECO:0000305|PubMed:26244737}. Note=Binds membranes via electrostatic interactions (PubMed:26244737, PubMed:29225173). Interaction with the membrane is conferred at least in part by the N-terminal positively charged and largely alpha-helical membrane-interacting region (MIR-WaaG) (PubMed:26244737). {ECO:0000269|PubMed:26244737, ECO:0000269|PubMed:29225173}.
Interaction partners:
- Lipopolysaccharide core heptose
- Lipopolysaccharide heptosyltransferase 3
- Lipopolysaccharide 1,6-galactosyltransferase
- Lipopolysaccharide glucosyltransferase WaaO
- Lipopolysaccharide 1,2-glucosyltransferase
- Lipopolysaccharide core heptose
- Lipopolysaccharide heptosyltransferase 1
- Lipopolysaccharide heptosyltransferase 2
- Putative lipopolysaccharide heptosyltransferase 4
- Lipopolysaccharide core biosynthesis protein WaaS
Sequence:
MIVAFCLYKYFPFGGLQRDFMRIASTVAARGHHVRVYTQSWEGDCPKAFELIQVPVKSHTNHGRNAEYYAWVQNHLKEHPADRVVGFNKMPGLDVYFAADVCYAEKVAQEKGFLYRLTSRYRHYAAFERATFEQGKSTKLMMLTDKQIADFQKHYQTEPERFQILPPGIYPDRKYSEQIPNSREIYRQKNGIKEQQNLLLQVGSDFGRKGVDRSIEALASLPESLRHNTLLFVVGQDKPRKFEALAEKLGVRSNVHFFSGRNDVSELMAAADLLLHPAYQEAAGIVLLEAITAGLPVLTTAVCGYAHYIADANCGTVIAEPFSQEQLNEVLRKALTQSPLRMAWAENARHYADTQDLYSLPEKAADIITGGLDG
Protein: Dual specificity mitogen-activated protein kinase kinase jkk-1 (MAP kinase kinase jkk-1) (EC 2.7.12.2) (JNK-1 activator kinase) (JNK kinase) (G5EDT6)
Organism: Caenorhabditis elegans
Function: Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and to arsenite.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10393177}. Perikaryon {ECO:0000269|PubMed:10393177}. Cell projection, axon {ECO:0000269|PubMed:10393177}.
Interaction partners:
- Stress-activated protein kinase jnk-1
- GLH-binding kinase 1
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase mlk-1
- Mitogen-activated protein kinase pmk-1
- PID domain-containing protein
- Mitogen-activated protein kinase pmk-3
- JNK-interacting protein
- Tyrosine-protein phosphatase vhp-1
Sequence:
MENVCFQQRLRDLETRVRKWKFLKLGLTEVRLRPRDRRSTSVDQKHKECSSTSSSPQHQRPNNIGYLTSPMERKFTPLSMKPSPSRRDTEKDALEYEFLEGYKKSGTLEIDGEKQVVDPNEIHIISLLGSGSCGVVESATVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYLDYDPASGSAYKFKAINGKCNQVADWFVDVIRLSKTEDELKSIPNTPCVN
Protein: Protein LYK2 (LysM domain receptor-like kinase 2) (LysM-containing receptor-like kinase 2) (Q9SGI7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May recognize microbe-derived N-acetylglucosamine (NAG)-containing ligands.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- LysM domain-containing GPI-anchored protein 2
- LysM domain-containing GPI-anchored protein 1
- LysM domain-containing GPI-anchored protein 3
- At5g62150
- At4g25433
Sequence:
MAVSVSKQYMTSLVVILLFISLSSLSPTSTSHSCDPVEEEEEASSFGYVCHSNLQKCHTFAILRAKPPFYSLSDLSRHLGLDADDEYVPKGQLLLIPIECRCNGSIYEASLIKNCVKGDTFRSVSQSLQGLTTCLSIREKNPHISEDKLGDNIKLRLAIRCSCPQEGVSNASFLVTYPVGVRDSVSSLAVRFNTTEDAIVSANNKSGVVPLKPALIPLDHKPEKQGSRKRNPSKKKRSKMKLMIAVSSAIAGVCGLVTLMVFGYLHWKKETQIQTQTQKWISNKDPETRQLSLSIRTTSDKKISFEGSQDGSILDSHNTVGTTTPRKPVLEIYAFEELEKATENFSSSNHIKGSVYFGSLKGKDLAIKQVNADEMKRFDFGLLNDQSHYYNHNVIRVLGTCFREIDQDSYLVFEYARNGSLWDWIQNKLAIKNQFIESCYCFLAWKQRIKICHDVAIALKYMHRINYVHGNIKSRNIFLNEDLRGKVGNFGMSKCVTNELATEENLIESSLSPASDIFAYGIIVMEVLSGQTPDMLLGLQEVETTSLGTQETFVSEWSRLRRLLGDKEKLREVMDSTLGESYSVDSAFEIASIARDCTAEEAESRPSAVEIAERVSRLVDDDEDEEDEAVIDRESTLISESSYKPLVKKSSIID