wanglab/gogpt-training-data huggingface dataset:
Protein: Late cornified envelope protein 3C (Late envelope protein 15) (Small proline-rich-like epidermal differentiation complex protein 3A) (Q5T5A8)
Organism: Homo sapiens (Human)
Function: A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
Interaction partners:
- Late cornified envelope protein 1A
- Loricrin
- Late cornified envelope protein 1B
- Involucrin
- Repetin
- Late cornified envelope protein 6A
- Late cornified envelope protein 1C
- HLA class I histocompatibility antigen, C alpha chain
- Late cornified envelope protein 2D
- Late cornified envelope protein 2C
Sequence:
MSCQQNQQQCQPPPSCPSPKCPPKSPAQCLPPPSSDCALSSGGCGPSSESGCCLSHHRHFRSHQCRRQRSNSCDRGSGQQGGGSCRGHGSGGCC
Protein: Outer surface protein A (OspA) (Q04968)
Organism: Borreliella burgdorferi (Lyme disease spirochete) (Borrelia burgdorferi)
Subcellular location: Cell outer membrane {ECO:0000305|PubMed:1356932}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Cell surface {ECO:0000305|PubMed:1356932}.
Interaction partners:
Sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDVPGGMKVLVSKEKNKDGKYDLMATVDNVDLKGTSDKNNGSGILEGVKADKSKVKLTVADDLSKTTLEVLKEDGTVVSRKVTSKDKSTTEAKFNEKGELSEKTMTRANGTTLEYSQMTNEDNAAKAVETLKNGIKFEGNLASGKTAVEIKEGTVTLKREIDKNGKVTVSLNDTASGSKKTASWQESTSTLTISANSKKTKDLVFLTNGTITVQNYDSAGTKLEGSAAEIKKLDELKNALR
Protein: Blown fuse protein (P91678)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNPKPTTTKLAEIEQFLLDVRAHFRASLETSEYENTSNLFHVTAAEQTAALLARCEILLAAASSASGSGSGLELGSGLGCADEQAAANHRSSLVDCVDSKVGAETGPSGYLEMLASPSPSKSSLSASREYIDLGSSGSLDRCSVNQPVPAAKDKEPHQQLYEICQGQGAGQDEDEAQQAITFTHEVFIDCPYADLPAGHLSLQRSTKYGQLQRIVPKRLFFDQTRKCYCGILNDWMLCYADGPTACRPSSTLYLKSSSIEIEHFGEGKRRDICFQITTDDPNKKFVYQANNEVDAKEWIHAIEAAIRGDAGAHSALKTPPPRKLATPPVQKKSTYTAADIIYEEPSPVYGLIDSSSMVLPKLPEKSNSPSALARRFEYDVPKCPAQPLQDTSSRVASVSGELESLGLLNEGDIKVQREPSSLHGSISLDFQARVKTVHSELSTQLSAAGPSPDRLKKAAKKSYSNGSEPEMLSLPDQPRQTPTKDQKKQRKSTTSPQSSPVSKDCDKLARNWFLSRLNKSTGLKATNTGSASPTNAKCKQSEKENLLTEAELGEGYDASPGDRDHGCRAAPATSPCLKAEAKSKVNMIINQFESSGHLSTMFSVEALAANALASLTSFCESDGCNNYEPIMPLATTPSSFLKKV
Protein: Endoglin (CD antigen CD105) (P37176)
Organism: Sus scrofa (Pig)
Function: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:8294451}; Single-pass type I membrane protein.
Interaction partners:
- CD34 molecule
- Thy-1 membrane glycoprotein
- Transforming growth factor beta-1 proprotein
- Platelet endothelial cell adhesion molecule
- Integrin beta-1
- CD44 antigen
- CD19 molecule.
- Ig-like domain-containing protein.
- Transforming growth factor beta-3 proprotein
- Activin receptor type-1-like
Sequence:
MDRGVLPQAIALLLAVCSFGPTAGLAEGVQCDLQPVDPKVTYTTSQVSEGCVAHVPNATVGVHILFLEFSKEVSTLELTVQMTNPNGARPQEVLLILSVNKNIHLTLQVPEIPLHLAYDSKLVFLQEAPKAVITELPPSTTKNQLFLWANTKGSIISAAELDNPQSILLRLDQAPTSPSRCTLEPRKDMGHTLEWKSHTQASVLGCHLEGVTGHKEAHILRVLPGSEAWPRTVTVEVELSCALRDPEAVLILQGPPYVSWLIDANHNVKAWTTGEYSFKIFPGSNIQGVNLPDTRQGLLEEARKLNASVIASFVELPLASVISLQDRSCGSGLQPSPTTVQITPPGEGCNQDLLLSLIQPRCSDDVMTLVLRKDLISTLGCTITSLTFWDPSCQAEDTDDKFVLRGTYSSCGMKVAENVVISNEVVVNLLSSSSPQRKQVQCINLDSLSFQLGLYLSPHFLQASNTIELGQQGFVQVSMSPSIPELMTQLDSCQLNLGPDVEMVDLIQNQEAKSSCVSLLSPSPGGDMRFSFLLRGYVVPMPTAGILSCTVALRPRTWSLDVHKTASTRLNIVSPGLPDKGLVLPAVLGITFGAFLIGALLTAALWYIHSHTRHPGKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA
Protein: CXXC-type zinc finger protein 4 (Inhibition of the Dvl and axin complex protein) (Q9EQC9)
Organism: Rattus norvegicus (Rat)
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11113207}.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Dishevelled segment polarity protein 3
- Dishevelled segment polarity protein 2
Sequence:
MHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF
Protein: Vascular cell adhesion molecule 1a (Vascular cell adhesion protein 1) (F6NRL9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- CD4-1 molecule
Sequence:
MFGVKCIPFALWIIILVAGENDLKLKLTPLNPAVHVGEDLRLTCSCNSCSVNVTFTWKTLLDRFHGGVVEDEPTVSRLLIRSISTEHNIKLVCKANCGSERSEKTSAINVYSFPHDPVLPKIKSLITNQEQMLSCTIYNVYPLERFQIEWLLGDKESVVSPDTYPEELYDHEQNYTSVLNYTHSADNLGKNITCKATLKLPNGFEKTRNSTLEYGPGTITISSYKASVKLGENFEITCHADGNPKPKISWWKHEEADPEPQSQNDKLIINNASRSQAGWYQCNASNDLGSLQKSIEVIVLGPPNTPKIQLSHSGELEEGENITIFCSSDGTLAELTISRQSQNAETGGHSQSAALLNLPSIQITDAGTYICEAKNDIGIERSTIEIRVKARQSMPDLMPDLPVAIIPAVGSVSLLTAVGLLIRHCRKKARSESCNLTELN
Protein: ABM domain-containing protein (Q72EZ0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
Sequence:
MHHDMIAITAEVVAREGHEAKAAELLAGLAAATSHHAGVLRYEVQRQAGNPRVFMVVELWADRASLEAHKNTEDMRCFIEAAPAVLEGAWLVREWQGVAASVIPAA
Protein: Aquaporin (H2FLH4)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Aquaporin-9
- Aquaporin
- Golgi pH regulator
- Golgi pH regulator
- Protein tweety homolog 1
- Bestrophin homolog 15
- RING-type E3 ubiquitin transferase
- Fibrinogen C-terminal domain-containing protein
- Aquaporin
Sequence:
MEVCPVYPDSENIPSPMVRSASDVILNSDPFNSTMENLKNSSDIVPKMVEDEKDYTIYSKCAAEFIAVLLFVYIGSMQAAGVFLHDGVLHAAFAHGVAIFVLAATFGGVSGAHINPAVTFGIALVGRISPIHAVCYVVSQLLGSVFGALLVRISLPYKMYNVISAGATLCGKGYNWQEGLTAEIVTTYILVQTVLLCAVDTDKNRLAPLAIGFSLIIEILAAGAISGASMNPARSFGPNIMGQVFLKPEHLDAQYMYWNYHWIYYIGPIIGAFIAAGVYRMFFARDYRVLA
Protein: CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha) (O43866)
Organism: Homo sapiens (Human)
Function: Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis. Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy.
Subcellular location: Secreted {ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991}. Cytoplasm {ECO:0000250|UniProtKB:Q9QWK4}. Note=Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity). {ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991}.
Interaction partners:
- T-cell surface glycoprotein CD5
- Urokinase-type plasminogen activator
- Endoplasmic reticulum chaperone BiP
- Macrosialin
- UDP-glucuronosyltransferase 1A1
Sequence:
MALLFSLILAICTRPGFLASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDAGASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCNKHAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECEDPFDLRLVGGDNLCSGRLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKCYGPGVGRIWLDNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICSG
Protein: Cellulose synthase (P93156)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
RRWVPFCKKHNVEPRAPEFYFNEKIDYLKDKVHPSFVKERRAMKREYEEFKVRINALVAKAQKKPEEGWVMQDGTPWPGNNTRDHPGMIQVYLGSAGALDVDGKELPRLVYVSREKRPGYQHHKKAGAENALVRVSAVLTNAPFILNLDCDHYINNSKAMREAMCFLMDPQFGKKLCYVQFPQRFDGIDRHDRYANRNVVFFDINMLGLDGLQGPVYVGTGCVFNRQALYGYDPPVSEKRPKMTCDCWPSWCCCCCGGSRKKSKKKGEKKGLLGGLLYGKKKKMMGKNYVKKGSAPVFDLEEIEEGLEGYEELEKSTLMSQKNFEKRFGQSPVFIASTLMENGGLPEGTNSTSLIKEAIHVISCGYEEKTEWGKEIGWIYGSVTEDILTGFKMHCRGWKSVYCVPKRPAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPLWYGYGGKLKWLERLAYINTIVYPFTSIPLLAYCTIPAVCLLTGKFIIPTLSNLTSVWFLALFLSIIATGVLELRWSGVSIQDWWRNEQFWVIGGVSAHLFAVFQGLLKVLAGVDTNFTVTAKAADDTEFGELYLFKWTTLLIPPTTLIILNMVGVVAGVSDAINNGYGSWGPLFGKLFFAFWVILHLYPFLKGLMGRQNRTPTIVVLWSILLASIFSLVWVRIDPFLPKQTGPVLKQCGVEC
Protein: MEP-1, isoform A (MEP-1, isoform B) (MEP-1, isoform C) (MEP-1, isoform D) (MEP-1, isoform E) (MEP-1, isoform F) (MEP-1, isoform G) (Q0E8J0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Chromodomain-helicase-DNA-binding protein Mi-2 homolog
- Simjang, isoform E
- Metastasis-associated protein MTA3
- Histone deacetylase HDAC1
- Methyl-CpG binding domain protein-like, isoform C
- Chromatin assembly factor 1 p55 subunit
- CDK2-associated protein 1, isoform B
Sequence:
MTEVDVVLPEGVAEPTTKLASASSSPKQSKPSADDVEQQVTTVEDDEEQVVEEQQEEDVHLPEAPSNEKLELLSAGGKDISKEDVAQASPQAPVADEIMEVDGTEDVEENEVENDDEDSQITSSSSKEPKLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLDGEESVASEGVVEEEPPAKQENGFGASPNQKENGQASIAEARAAIAPSDGGVVNLDEDSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKMRKAQVQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTAHSTVARKAMDSKKNSAQSSGSGSGAGMSRSSLGAANDSLLKPLKINDEITIIPQPASKPRITNMESHVID
Protein: Cardiac troponin T (Troponin T type 2a (Cardiac)) (Q90Y46)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDNEEVEEYEEQEEEQVEEEEEVQEEAQHDEEAQQEENAGGDEETTQEHDGEEETEDGGEEAKPKFLKPFMLPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQTLIEAHFESRKKEEEEIISLKDRIEKRRSERAEQQRIRSERERERQKRLEEERARKEEEEAKKRAEDDAKKKKTLTSLHFGGYMQKIERRSGKKQTEREKKKKIFGDRRKPLDIDNANESALREKAKELWSWMRELEAEKFELQYQFGKQKYEINVLRNRVSDHQKTSKRTKRGLRK
Protein: Derlin (E5RGY0)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}.
Interaction partners:
Sequence:
MLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ
Protein: Netrin receptor DCC (Tumor suppressor protein DCC) (P70211)
Organism: Mus musculus (Mouse)
Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Netrin-1
- Focal adhesion kinase 1
- Draxin
- Cell adhesion molecule DSCAM
- Netrin receptor UNC5D
- Caspase-9
- Netrin receptor UNC5A
- Netrin receptor UNC5C
- Netrin receptor UNC5B
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISRTAKVTVAGPLRFLSQTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKPTGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAKLMIPMEAQSSNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTQSVSEGPTTQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF
Protein: Disulfide-bond oxidoreductase YfcG (EC 1.8.4.-) (GSH-dependent disulfide-bond oxidoreductase YfcG) (GST N1-1) (GST-like protein YfcG) (Organic hydroperoxidase) (EC 1.11.1.-) (P77526)
Organism: Escherichia coli (strain K12)
Function: Exhibits a very robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Has also a low GSH-dependent hydroperoxidase activity toward cumene hydroperoxide, but does not reduce H(2)O(2), tert-butyl hydroperoxide, benzyl peroxide, or lauroyl peroxide. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity using glutathionylspermidine (GspSH) as the nucleophilic substrate. Is involved in defense against oxidative stress, probably via its peroxidase activity.
Interaction partners:
- Glutathione S-transferase YfcF
- Dihydroneopterin triphosphate 2'-epimerase
- Uncharacterized protein YbhP
- Inner membrane protein YphA
- Uncharacterized protein YcgB
- Outer membrane lipoprotein Blc
- Mannosyl-3-phosphoglycerate phosphatase
- Glutathione S-transferase GstA
- Trehalose-6-phosphate synthase
Sequence:
MIDLYFAPTPNGHKITLFLEEAELDYRLIKVDLGKGGQFRPEFLRISPNNKIPAIVDHSPADGGEPLSLFESGAILLYLAEKTGLFLSHETRERAATLQWLFWQVGGLGPMLGQNHHFNHAAPQTIPYAIERYQVETQRLYHVLNKRLENSPWLGGENYSIADIACWPWVNAWTRQRIDLAMYPAVKNWHERIRSRPATGQALLKAQLGDERSDS
Protein: Non-structural protein (Q5Q0J3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEMAEGEGTTEENYDVDIATTASSLGGSGVFHIINDIVGFVLYMHQQIPSVLQDMSLEFEGLQTEFMDLETNLAEPQVKPLVRRKLMSRKREVKNEIKKLEKLMKTISSLRSALQLMIREAPGIQKVVLILGGSPLRPQNAYELLFTQRRDHVLGYEGDFAKSKAAEALSKKTIRALISTGAGSTSYPGPMRLFILVHAPPTLNLPQHFLPKRDFRYNRKFVPSKLRFKCRTQDNATNSPPTNDLIWYQCRHVIKGLAFHQPVEE
Protein: Protein translation factor SUI1 homolog, putative (Q385I4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S33, putative
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S14
- 40S ribosomal protein S24
- 40S ribosomal protein S17, putative
- Eukaryotic translation initiation factor 1A, putative
- 40S ribosomal protein S13, putative
- 40S ribosomal protein S25
- 40S ribosomal protein S4
- 40S ribosomal protein S5, putative
Sequence:
MNANDEMSALMDQKRTVQNALEAQKVHIRVQQRRGRKFVTSVQGLNQQLNFRRINREFMRRWGCNGTVITTPEAGTVIQLQGNWSEEIRTFLLEEHMATEQNLEIHSLN
Protein: Transport permease protein (O33188)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361157}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361157}.
Interaction partners:
- Probable conserved ATP-binding protein ABC transporter
- HTH tetR-type domain-containing protein
- Multidrug efflux system ATP-binding protein Rv1218c
- Multidrug efflux system permease protein Rv1217c
- Putative 3-methyladenine DNA glycosylase
- Probable second part of macrolide-transport ATP-binding protein ABC transporter
Sequence:
MILLVPILIITLMYFMFENVPHRPGTPSGFNTACLVLLGLFPLFVMFVITAITMQRERASGTLERILTTPLRRLDLLAGYGTAFSIAAAAQATLACIVAFWFLGFDTAGSPVWVFAIAIVNAVLGVGLGLLCSAFARTEFQAVQFIPLVMVPQLLLAGIIVPRALMPTWLEWISNVMPASYALEALQQVGAHPELTGIAVRDVVVVLSFAVASLCLAAVTLRRRTS
Protein: Replicative DNA helicase (EC 5.6.2.3) (Q9A7Q5)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- DNA primase
- Chromosomal replication initiator protein DnaA
- DNA polymerase III subunit gamma/tau
- Single-stranded DNA-binding protein
- Recombination protein RecR
- DNA-directed RNA polymerase subunit alpha
- DNA 3'-5' helicase
- DNA polymerase III subunit alpha
Sequence:
MPMSLVPALDLVLPGLPEPTINVAPHNMEAEQALLGVLLYDNAAYERLSDNLQARCFYEPFHQRLFQAIETHVRKGQLAEPILLADEFKKDPAFEELGGLRYLADLVDRAPPAANVGDYARVIFDLSLRRELIRIGGDIATAAQGGNDEKRNARDQIEAAEQSLYSLAESGAASSGFVSFGDALRGAVEMTAEAYSRDGGMSGVSTDLMDLDQKIGGLHPSDLIILAGRPSMGKTALATNIAFNIAKKYAYEIQPDGTKKTVQGGVVAFYSLEMSAEQLALRMLADASGVSGDRLRKGEIDASEFGRVRDAAMELQNAPLYIDATGGISIAKLTARARRLKRQVGLDLIVVDYLQLVTGSDLGANANRVQEVSQITMGLKALAKELSVPVIALSQLSRQVEQRDDKRPQLSDLRESGSIEQDADMVWFVYREAYYVGRAEPREGTPEHLTWQEEMDRLQGLAEVIIAKQRHGPIGTVRLSFNSDTTRFGNLARDHYFAQARNIPSDE
Protein: Olfactory receptor (Q7TR57)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MADVNFTFVTEFILLGLTDRDELKVFLFILFLLIYVISLVGNLGMFMLIHITPKLHTPMYHFLRSLSFVDACYSSVFAPTLLLNFFVERETISFSACILQYFLFASLLTTEGFLLAAMAFDRYVAIVNPLTYTVVMTKLICVLLVLGSCLGGTITSLTHTIGLIKLSFCGPNVISHFFCDLPPLLKLSCSDTSMNELLLLVFSGVIAITTLLTVVLSYIFIVAAILRIRSAAGRHKAFSTCASHLTAVTLFYGSISFSYIQPSSQYSLEQEKVVSVFYTLVIPMLNPLIYSLRNKEVKDAVKRVMEIKHSLH
Protein: Putative claudin-25 (C9JDP6)
Organism: Homo sapiens (Human)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Claudin-34
- Claudin-17
- Claudin-16
- Claudin-8
- Claudin-11
- Tight junction protein ZO-3
- Claudin-23
- Claudin-20
- Occludin
- Tight junction protein 1
Sequence:
MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEMETWIMGIWEVCVDREEVATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGGLLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSFHLMLRPRNLVI
Protein: Rhophilin-2 (GTP-Rho-binding protein 2) (Q8BWR8)
Organism: Mus musculus (Mouse)
Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Transforming protein RhoA
- Rho-related GTP-binding protein RhoB
Sequence:
MTDTLLPAAPQPLEKEGDDYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEHYSEDSYLYEDDIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDSFTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQAGLESAVDAFQRAAGVLNYLKETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKVCLPGIQNEFFVLVKVAQEAAKVAEAYRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDRMPEGMTPLATLKNAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAHQRTQLKHTQHREDDDLLNLIDAPDVLPKTEREVKITFPDFSKVTVTDFFQKLGPLSVFSASKRWSPPRGIHFTVEEGDLGFTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVSIQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNKCATYSVGMQKTYSMICLSMDDDDKADKTKKISKKLSFLSWGTSKNRQKSASTLCLPEVGLARSQNKKKLPTPFSLLNSDSSLY
Protein: Uncharacterized protein At2g03420 (Q9ZQ78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMQTKISSFSRPSFSLYEPRVIHHPRISMALSSSAPSPFHHLLCKSTFPLAASLTLLLSPCTAEAGLMSGSPGIESVPGPELPKIEFLDRFNAKNQKFYAENDARFKDSPLLKKLLENSKLNKEKNEREIQDKYCLRGAEWGVGDCSTTGMTDEEKEKFITMLKKKTGVE
Protein: Required for respiratory growth protein 9, mitochondrial (P40156)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Required for respiratory growth protein 8
- Required for respiratory growth protein 7
- Genetic interactor of prohibitin 5, mitochondrial
- Regulator of phospholipase D SRF1
- Uncharacterized protein YDL129W
- Increased recombination centers protein 19
Sequence:
MNILRIACRSFHCLRCGPLLNENRGWSSKKIIKLVNKSSLSNKEFTEKVRDGTKDIPEWKKQKMAVRKKLQGQRWNPPKKISQEQMEALRLLKFNFPELTASDLADRFKISPEAVRRILKSNWKRTDEENNNTYERWKRRGERIKEMYQRKEDADFVSNQIVTSRKIILGSNSNSPELIARNVRTFKPFKPNNSTPEKKNTNKLYILKHLGSKQ