Protein: Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC) (P34036)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Cytoplasmic dynein 1 intermediate chain
- Tubulin beta chain
- Tubulin alpha chain
- Tubulin alpha chain
- Dynein light chain, cytoplasmic
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynein light chain Tctex-type
- Dynactin subunit 2
- Dynein light chain roadblock
- Dynactin 150 kDa subunit
Sequence:
MEDQQINVDSPTSGTNTPPVVTPTTSVISEQTLEETVKYLCKICPTLLDGDQSVFQNNLSNQIPPENMNKLKKFISDSKIPVLLIQKTNPTINSSNQTSTTTSSSSSSDDNTLTSSQQQSKESFNFEIEVKFGGENKSTLAIVKRIPESIVEYSSNKSIASQLQVLNLGDGSPMDTLHNYIHNSVAPFVRSYILSASKDDATTPSGGSADKSITSQNLDKEMKQSIGAVNQKIAELEISLYNCKQQVQIPEVTLAINPEIKSISKRLKETTGRTIKPDDLGDKASSPEFLNLLQAGTTTWAKNIQNVTKHNLIENLPSDVSTSQEINFWIELETSLQNIDQQLKSPEVEVTLATLRQAKRFIASAPFETDTIGVRKAMDKVQSYKTLFKDFPITPLLTATDLDSISSSVAAIFSHLKKTKNPYYPIPRYLSFLEAIGRDMCNKVYQILRQKNLMNIDYNDFEHLNRSVRALFTLWDDQFGAFRDILRDLAKKRGNERIPLIVNIDNRIQLVIIKIGKFRKQHEDLKNVVSNVLPGSQLGGGVVQTNTSNPTSPQKQEINAIEEINQAYLEFKEIDVLQLSKEGEEIWDAVVKRYNSRTDRVETYITVKLRDRLATAKNANEMFRVYQKFKDLLKRPKIRGATHEYESQLIERVKEDIRVLHDKFKMQYNNSEAYYMSQLRDLPPVSGAIIWARQIERQLDTYMKRVANVLGDSWESDAEGQKLKSESDQFRHKLNTDHIFSKWADETEKRSFDISGRILTIVKRGNKLALDINFDSHIIMLFKEVRNLQWLGFRVPLKISFISQGAKQVYPFAVSLKETLRTYAQTSGKVTPEFSTLVASYKRDVQANITEGFRLKWETIPKVDPYVRKLSTSINNFRDKVDDLIVKYSEIKKQLDGLKSCPFKSESFNEIIANIQKVVDELNLANYSNLPQWVTQLDAQVESMLIERLIDAINSWVQLIEGKEDQKDSQSTSGSSNKGGKLNRMNYSIRNKSDEENSSDLTQPQQSQQQQQTISIKPKLEKTIHEIVIRNQILSLSPPLEVARVNWIDQLHSWLNICCDLPRIQSSRYDESAMVHRGGVDSKKQSTFRDMLPKLPQGSLESAYSAITNKLEQVQQYVSIWLQYQSLWDMDSSFVYSKLGDDLNKWQLLLNQIKKSRSTFDNSSTEKQFGPLTIDYTQVQASVNNKYDYWHKDILGHFGSKLAEKMNQFYETISSSRQELEKLSVETVSTEEAVHFIIQIQDMKKKLSSWEADLRYYRTGQDLLQRQRFSFPNDWLDCERVEGEWSAFNEILNRKNATISEAIPQLQAKILQESKSINDRIKDFIDEWTANKPLQGSIKHSTALETLKIFEGRLIRLREESDRLSKAKQALDLTDTTGSSSSDQDRLVPVEEEIQDLKAVWVELSNTWQEIDSLKETAWSAIIPRKVRKSLEDTLQKLKNLPNRIRQYSAFDHAQNLIKIYLKGNAIITDLHSEAIKDRHWKILKKRLNTNWIITELTLGSIWDSDLARNENIYREVITAAQGEIALEEFLKGVREFWTTLELDLVNYQRKCKLVRGWDDLFNKLAEHLNSISAMKMSPYYKVFEEEANHWDDRLNKVRSLLDVWIDVQRRWVYLEGIFSGSGDINQLLPAESTRFKSINSEFIAILKKVSGAPLILEVLAIERIQQTMERLSDLLGKVQKALGEYLERQRSAFARFYFVGDEDLLEIIGNSKDIIKIQKHFRKMFAGLANLTLDDEKTTIIGMSSAEGETVTFKKPISIANGPKIHEWLTMVESEMKSTLATLLSESLQHFNQVDVNDHSKYSEWVDNYPTQLVLLTSQIVWSTQVDQALGGGTLQQSKIQEQLQSIEQTTQMILNNLADSVLQDLSAQKRKKFEHLITELVHQRDVVRQLQKCKNLTGNKDFDWLYHMRYYYDATQENVLHKLVIHMANATFYYGFEYLGIGERLVQTPLTDRCYLTLTQALESRMGGNPFGPAGTGKTETVKALGSQLGRFVLVFCCDEGFDLQAMSRIFVGLCQCGAWGCFDEFNRLEERILSAVSQQIQTIQVALKENSKEVELLGGKNISLHQDMGIFVTMNPGYAGRSNLPDNLKKLFRSMAMIKPDREMIAQVMLYSQGFKTAEVLAGKIVPLFKLCQEQLSAQSHYDFGLRALKSVLVSAGGIKRKCQPPQLPPITDAESKTKADQIYCQYEIGVLLNSINDTMIPKLVADDIPLIQSLLLDVFPGSQLQPIQMDQLRKKIQEIAKQRHLVTKQEWVEKILQLHQILNINHGVMMVGPSGGGKTTSWEVYLEAIEQVDNIKSEAHVMDPKAITKDQLFGSLDLTTREWTDGLFTATLRRIIDNVRGESTKRHWIIFDGDVDPEWVENLNSLLDDNKLLTLPNGERLALPNNVRVMFEVQDLKYATLATISRCGMVWFSEEILTTQMIFQNYLDTLSNEPFDPQEKEQQKRNENAQLQQQQQTTITSPILTSPPTTSSSSRSTTSTTSMIPAGLKVQKECAAIISQYFEPGGLVHKVLEDAGQRPHIMDFTRLRVLNSFFSLMNRSIVNVIEYNQLHSDFPMSPENQSNYITNRLLYSLMWGLGGSMGLVERENFSKFIQTIAITPVPANTIPLLDYSVSIDDANWSLWKNKVPSVEVETHKVASPDVVIPTVDTTRHVDVLHAWLSEHRPLILCGPPGSGKTMTLTSTLRAFPDFEVVSLNFSSATTPELLLKTFDHHCEYKRTPSGETVLRPTQLGKWLVVFCDEINLPSTDKYGTQRVITFIRQMVEKGGFWRTSDHTWIKLDKIQFVGACNPPTDAGRVQLTHRFLRHAPILLVDFPSTSSLTQIYGTFNRALMKLLPNLRSFADNLTDAMVEFYSESQKRFTPDIQAHYIYSPRELSRWDRALLEAIQTMDGCTLEGLVRLWAHEALRLFQDRLVETEEKEWTDKKIDEVALKHFPSVNLDALKRPILYSNWLTKDYQPVNRSDLREYVKARLKVFYEEELDVPLVLFNEVLDHILRIDRVFRQPQGHALLIGVSGGGKSVLSRFVAWMNGLSIYTIKVNNNYKSSDFDDDLRMLLKRAGCKEEKICFIFDESNVLESSFLERMNTLLAGGEVPGLFEGEEFTALMHACKETAQRNGLILDSEEELYKYFTSQVRRNLHVVFTMNPASPDFHNRSATSPALFNRCVLDWFGEWSPEALFQVGSEFTRNLDLENPQYIAPPVFIQEAEIMGNNLMAIPPSHRDAVVSSLVYIHQTIGEANIRLLKRQGRQNYVTPRHYLDFINQVVLLINEKRDQLEEEQLHLNIGLKKLRDTEAQVKDLQVSLAQKNRELDVKNEQANQKLKQMVQDQQAAEIKQKDARELQVQLDVRNKEIAVQKVKAYADLEKAEPAIIEAQEAVSTIKKKHLDEIKSLPKPPTPVKLAMEAVCLMLGGKKLEWADIRKKIMEPNFITSIINYDTKKMMTPKIREAITKGYLEDPGFDYETVNRASKACGPLVKWATAQTYYSEILDRIKPLREEVEQLENAANELKLKQDEIVATITALEKSIATYKEEYATLIRETEQIKTESSKVKNKVDRSIALLDNLNSERGRWEQQSENFNTQMSTVVGDVVLASAFLAYIGFFDQNFRTDLMRKWMIRLDSVGIKFKSDLSVPSFLSKPEERLNWHANSLPSDELCIENAIMLKRFNRYPLVIDPSGQAMEFLMNQYADKKITKTSFLDSSFMKNLESALRFGCPLLVQDVENIDPVLNPVLNKEIRKKGGRILIRLGDQDVDFSPSFMIFLFTRDPTAHFTPDLCSRVTFVNFTVTPSSLQSQCLHEALKTERPDTHKKRSDLLKIQGEFQVKLRILEKSLLNALSQASGNILDDDSVISTLETLKKETTEIALKVEETETVMQEISEVSALYNPMALSCSRVYFAMEELSQFHLYQFSLRAFLDIFYNLLNNNPNLVDKKDPNERLVYLSKDIFSMTFNRVTRTLLNDDKLTFALQLTIISVKGTSNEIEESEWDFLLKGGDNLTSIKETIPQLDSLLSTTQQKWLICLRQQVPSFSKLVDHIQQNSSDWKQFFGKDQVGEPIIPESWIVAQAQLSNQQSTIVSNFRKILLMKAFHSDRVLQYSHSFVCSVFGEDFLNTQELDMANIVEKEVKSSSPLLLCSVPGYDASSKVDDLALQLHKQYKSFAIGSPEGFELAEKSIYAAAKSGTWVLLKNIHLAPQWLVQLEKKLHSLSPHPSFRLFMTSEIHPALPANLLRMSNVFSYENPPGVKANLLHTFIGIPATRMDKQPAERSRIYFLLAWFHAIIQERLRYIPLGWTKFFEFNDADLRGALDSIDYWVDLYSKGRSNIDPDKIPWIAVRTILGSTIYGGRIDNEFDMRLLYSFLEQLFTPSAFNPDFPLVPSIGLSVPEGTTRAHFMKWIEALPEISTPIWLGLPENAESLLLSNKARKMINDLQKMQSSEEDGEDDQVSGSSKKESSSSSSEDKGKAKLRATITEWTKLLPKPLKQLKRTTQNIKDPLFRCFEREISTGGKLVKKITNDLANLLELISGNIKSTNYLRSLTTSISKGIVPKEWKWYSVPETISLSVWISDFSKRMQQLSEISESSDYSSIQVWLGGLLNPEAYITATRQSASQLNGWSLENLRLHASSLGKISSEGGASFNVKGMALEGAVWNNDQLTPTDILSTPISIATLTWKDKDDPIFNNSSSKLSVPVYLNETRSELLFSIDLPYDQSTSKQNWYQRSVSISSWKSDI