wanglab/gogpt-training-data huggingface dataset:
Protein: Activity-dependent neuroprotector homeobox protein 2b (Si:ch211-129n15.3) (A0JMC9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYQFPVKGLEKIRRTRRKVKNILGEFGLEACLNLGQELQEYYPGDNIFDATDWCNLSDGFDGRWRKKWGYRTQGLCCTLCNFSTRSWHTYKTHVQRYHDEEEHMCKLAACASCPFIAHPRLVCKHLKLFHNEDTKSETSAAPQLPPRAVNGTTFQCRRCHIQDTLLYSVKKHVLLYHYTSTLNKYAGQRTEQELVALGDRSQKFYCKKCYISAESSEHLLYHLLTSDKHKELDVHIRSLIFETDNKKQFPALAPKAQGPSPVMMMKDQPAATATLAAGGITGVENGGSAVIATPGTSQAFLPTQASALVQLASAEAKGLLRPGVPMGFQNTQMPRPALPPPPNSIPPNQMPVRVGLPNQAQLQPVSRQIVLPPGVRLNVPGVRPPTPQSFSANPRLPLNQPPSGGTMLTSQSLLSHLIPTGNKVDGLPTYTLAPLQVLSVQANNSQGVSKPQLPPSQNNPAAQQNKQSSGLSTPKQTKKWITCPICNELFPSDIYESHPEVHKEAAKLPKVGLAARAPFLKKMPDKTVKCLTCKILISEKGVFEHLLHGMNCLFCSGLFYSIKQLVDHIQIEHNVSRKSNCDFMRREYRLYTDDSGYLLFPYFDIRTTAPKLIMGEKELNLALVTSSLDLIFVKMLPNNPQGVNQQYTPCKMPTPKPDSTECPFCSEKLLNKECYHMHLKEKHFIVPTLHAILKTPSYRCLYCGGVYTGKTTTKAIIVHLAKCRSAPKSVRESDKLTLGLAVTPKANRAHGSYPAHPRQITGPTPTSAQASVPSTQPPESEAEMQSKMRLEIAFREAMEANRKEREERLARKRKLERDRLAGLTLPSPDIVVDPSVKLALDPAGMELRTFEDRREFVNKYFNTQPYPLKKEIIALSARLLLNKTDVACQISSKRTRCMKNIQKMKAVVLLGFNMTEVMKLKHDLLIPEIEPEKVATMADTDMEVDQE
Protein: KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) (Q9H9L4)
Organism: Homo sapiens (Human)
Function: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:20018852}. Mitochondrion {ECO:0000250|UniProtKB:Q8BQR4}.
Interaction partners:
- WD repeat-containing protein 5
- KAT8 regulatory NSL complex subunit 3
- KAT8 regulatory NSL complex subunit 1
- Microspherule protein 1
- PHD finger protein 20
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Histone acetyltransferase KAT8
- Host cell factor 1
- MSL complex subunit 3
- PHD finger protein 20-like protein 1
Sequence:
MNRIRIHVLPTNRGRITPVPRSQEPLSCAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGVSFCAEHVRRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDGMQCPPSPLLFDPSLTLEDHLVKEIAEDPVDILGQMQMAGDGCRSQGSRNSEKASAPLSQSGLATANGKPEPTSIS
Protein: Cytochrome P450 734A1 (EC 1.14.-.-) (Protein PHYB ACTIVATION-TAGGED SUPPRESSOR 1) (O48786)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis. Inactivates the BRs castasterone (CS) and brassinolide (BL) through carbon 26 hydroxylation. Acts in association with CYP72C1 to inactivate BRs and modulate photomorphogenesis.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 85A1
- Cytochrome P450 85A2
- Steroid 5-alpha-reductase DET2
- Proteasome subunit alpha type-3
- Protein BRASSINAZOLE-RESISTANT 1
- Protein BRASSINOSTEROID INSENSITIVE 1
- BAHD acyltransferase BIA1
- Protein BRASSINAZOLE-RESISTANT 2
Sequence:
MEEESSSWFIPKVLVLSVILSLVIVKGMSLLWWRPRKIEEHFSKQGIRGPPYHFFIGNVKELVGMMLKASSHPMPFSHNILPRVLSFYHHWRKIYGATFLVWFGPTFRLTVADPDLIREIFSKSEFYEKNEAHPLVKQLEGDGLLSLKGEKWAHHRKIISPTFHMENLKLLVPVVLKSVTDMVDKWSDKLSENGEVEVDVYEWFQILTEDVISRTAFGSSYEDGRAVFRLQAQQMLLCAEAFQKVFIPGYRFFPTRGNLKSWKLDKEIRKSLLKLIERRRQNAIDGEGEECKEPAAKDLLGLMIQAKNVTVQDIVEECKSFFFAGKQTTSNLLTWTTILLSMHPEWQAKARDEVLRVCGSRDVPTKDHVVKLKTLSMILNESLRLYPPIVATIRRAKSDVKLGGYKIPCGTELLIPIIAVHHDQAIWGNDVNEFNPARFADGVPRAAKHPVGFIPFGLGVRTCIGQNLAILQAKLTLAVMIQRFTFHLAPTYQHAPTVLMLLYPQHGAPITFRRLTNHED
Protein: Insulin [Cleaved into: Insulin B chain; Insulin A chain] (P01318)
Organism: Ovis aries (Sheep)
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MALWTRLVPLLALLALWAPAPAHAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCAGVCSLYQLENYCN
Protein: Glutamate receptor 2.1 (Ligand-gated ion channel 2.1) (AtGLR3) (O04660)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Two pore calcium channel protein 1
- Putative cyclic nucleotide-gated ion channel 7
- Probable cyclic nucleotide-gated ion channel 5
- Putative cyclic nucleotide-gated ion channel 19
- Protein MID1-COMPLEMENTING ACTIVITY 2
Sequence:
MKRENNLVLSLLFFVIVFLMQVGEAQNRITNVNVGIVNDIGTAYSNMTLLCINMSLSDFYSSHPETQTRLVTTVVDSKNDVVTAAAAALDLITNKEVKAILGPWTSMQAQFMIEMGQKSQVPIVTYSATSPSLASIRSQYFFRATYDDSSQVHAIKEIIKLFGWREVAPVYVDDTFGEGIMPRLTDVLQEINVRIPYRTVISPNATDDEISVELLRMMTLPTRVFVVHLVELLASRFFAKATEIGLMKQGYVWILTNTITDVLSIMNETEIETMQGVLGVKTYVPRSKELENFRSRWTKRFPISDLNVYGLWAYDATTALALAIEEAGTSNLTFVKMDAKRNVSELQGLGVSQYGPKLLQTLSRVRFQGLAGDFQFINGELQPSVFEIVNVNGQGGRTIGFWMKEYGLFKNVDQKPASKTTFSSWQDRLRPIIWPGDTTSVPKGWEIPTNGKRLQIGVPVNNTFQQFVKATRDPITNSTIFSGFSIDYFEAVIQAIPYDISYDFIPFQDGGYDALVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLVVPVKDSVRRSSTIFLMPLTLALWLISLLSFFIIGLVVWVLEHRVNPDFDGPGQYQLSTIFWFSFSIMVFAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLAKGESVGYQSSFILGRLRDSGFSEASLVSYGSPEHCDALLSKGQAEGGVSAVLMEVPYVRIFLGQYCNKYKMVQTPFKVDGLGFVFPIGSPLVADISRAILKVEESNKANQLENAWFKPIDESCPDPLTNPDPNPSVSFRQLGFDSFWVLFLVAAIVCTMALLKFVYQFLKENPNQRNLRVLWEKFNEPDQKSYIKDVTKCQCSSGQGMPKNGQEGANAVNNGN
Protein: Uncharacterized protein C1786.04 (Q9C116)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTRRFKVKMNQPRFYFLSLQSYVLVNWQYAICDSQDSNYKQVGGLACIYMRETLFGIHNLSVASPFMIGSLQPLVPWLIRQKWHKIDEPRQLPSTHHALPEGRWRSLTVSL
Protein: RB binding protein 4, chromatin remodeling factor (A0A8I6AQI0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMVPVLKLELPGLCFQGSQSLPHLLDLRLGVLQSSGPRLFPFQEPKQLGFIFVLQALTAFRHEIFKLCRQPSALLEKVPIALGRGCL
Protein: Nodulin-related protein 2 (Q9XI93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be a negative regulator of the ABA signaling/synthesis pathway.
Interaction partners:
- FIP1[V]-like protein
- Trigger factor-like protein TIG, Chloroplastic
- F16A14.15)
- Thylakoid lumenal 16.5 kDa protein
- RuvB-like helicase
- RuvB-like helicase
- At5g20030
- Phosphoserine aminotransferase 1, chloroplastic
Sequence:
MNFISDQVKKLSSSTPEEPDHNKPVEGTETATRPATNAELMASAKVVAEAAQAAARNESDKLDKGKVAGASADILDAAEKYGKFDEKSSTGQYLDKAEKYLNDYESSHSTGAGGPPPPTSQAEPASQPEPAAKKDDEESGGGLGGYAKMAQGFLK
Protein: PRA1 family protein (Q389C6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363107}.
Interaction partners:
Sequence:
MRSATEYTDGLLGLPTSPQLATHKERSGGTQVGLCPCFRIAAGEFMHIYAILKEERLSWRDDFFDVSQLSVPRSTSEVLERLNLNLPFYAANYMTVCIVVTSLLLFLNPYFLILLCSLVLLLRGLFLHGKYQGRPNHCIYIGGVTVSYYRLLIVTLFVLFLFPVVWSGILNLLFLLLVGAALVLPHAVSRRPVYFHDEELEKRRPKALQYVVVFLLHFLSYMESPNK
Protein: GID complex subunit 5 (Glucose-induced degradation protein 5) (O13986)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GID complex subunit 8
- GID complex subunit 9
- E3 ubiquitin-protein ligase gid2
- GID complex subunit 7
- GID complex subunit 1
- GID complex substrate-recognition subunit 4
Sequence:
MVAINDSTDSSFFKENPKIFKDEHELLRYIVPFKNWVIGRPDRKEYAIRNGAPKLLLNLFSLENLSMNEKYQVFVVLNSLMSEDQDPFVQFLRHEDLLSVMQMISKRDSTPYGMLNITLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSVCFNLPATKKEQKNLILESVLLAVAALTTSKDEYRKLIVDAKYLPVIINALKINSNSVKKAACECLLSLSRSVYILRTGLADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDSILRQTKLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKERASILQNLGFGECLQMLQNHSSPDVRERVKDALMYINVTD
Protein: PPFIA binding protein 2 (G3V9H6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDGDIDVYKHFSWLKRSQVNHHSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQKEQEEKQRKAEELLQELKHLKIKVEELENERNQYEWELKATKAEVAQLQEQVALKDAEIERLHSQLSRSSALHSDHAERDQEIHRLKMGMETLRVANEDKDRRIEELTGLLNQYLRVKEIVMATQGSSERTLSINEDEIEGSFRKWNTTSKSPEEVMKQEVSPRCSSPTPGPPPLPQKSLETRAQKKLSCSLEDLRCESGNKCINGNQTSPVGEPKDSSFLAEQKYPTLPGKLSGATPNGEAAKSPPTASLQPDSSGSSQPKLRDTEGGWEDIVMTNELSSTSSGTESSPQSPLTPDGKRSPKGIKKFWGKIRRTQSGNFNTDTPGMVEFRRGGLRATAGPRLSRTRDTKGQKCDANAPFAQWSTERVCTWLQDFGLAQYVIFARQWVASGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHVWVTRWLDDIGLPQYKDQFYESRVDGRMLQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPNCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKRDKMASPAYTPLTTTAKVRPRKLGFSHFGNMRKKKFDESTDYICPMEPGDAVSDSHRVYGVYRGLSPLDNHELDGLDQVGQIS
Protein: GA binding protein transcription factor subunit beta 1 (F5H7I4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV
Protein: DNA replication regulator SLD2 (DNA replication and checkpoint protein 1) (P34252)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA replication regulator DPB11
- Cell division control protein 45
- Mitochondrial morphogenesis protein SLD7
- DNA replication licensing factor MCM4
- Cell division control protein 6
- Minichromosome maintenance protein 10
- DNA replication regulator SLD3
- DNA replication licensing factor MCM2
- DNA replication complex GINS protein SLD5
- DNA replication complex GINS protein PSF3
Sequence:
MYSFELDKLKIELKTWEHDFIDKNKREPTRDDIKSLRTVRQMYKQYSTLKKKQSLQRQKVDTQESVELPAHKKDHDEVVEIGPTPQVYGKAISIFDMNLSPIKPIYMTFTNNIDVNNDNSKTISNESSPRKTILLKSSPADRTLVAEPISSVKRQLNFQMLNASSTRTPTSSPCKNRNGKLVEIKKCSPTINPPLESGKPSGYYGPNSPLKLDEENIHLNISLNSSTKRRLQIAYPSLQKTPSKDQADISTSFSPSPLIRRPLTKSLIELAREHTEIVKEFGVLQEEDIEEEEEGEEGENGYDEKNHEDDFGLEDELIRPKVVKDIFQEDDDNDDSQAREDTFIRKRPKRRKVIRRLRDNDPETETAGFERDVHKELVKLKRRKVAEFLGSTSQISDTEFEHDPEASSGVVSSEQKPTAKRKGRKKYNLVSNNFRRLKLPKKNRFSNGRWGRR
Protein: E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) (Q75N03)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIY2}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:Q9JIY2}.
Interaction partners:
- RNA-binding protein 15
- N
- Pre-mRNA-splicing regulator WTAP
- Protein virilizer homolog
- Zinc finger CCCH domain-containing protein 13
- N
- Putative RNA-binding protein 15B
- Cadherin-1
- RNA N
- Monocarboxylate transporter 5
Sequence:
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
Protein: Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (Q4V8Z9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADFESVDFLRERHVRFFQRCLYVLPERYAPYETSRLTIAFFSLSGLDVLGALDVVDRHSLIEWIYSLQILPTADQSNLQRCGFRGSSHIGVPYSSSKGPGAPHPYDSGHVTMTYTGLACLLILGDDLGRVDRAACVSGLRALQLEDGSFYAVPEGSENDMRFVYCAACICFMLDDWSGMDRQKTIDYIRRSTSFDFGIGQGAGLESHGGSTFCAVASLCMMGKLREVFSERELGRLRRWCVLRQQNGFQGRPNKPVDTCYSFWVGATLQLLDVFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDPLHTYFGICGLSLMGEAGLQPVHAALNISLRASDSLRRLHECWRRSRT
Protein: Phospholipid--sterol O-acyltransferase (EC 2.3.1.-) (Lecithin-cholesterol acyltransferase-like 2) (Q4VCM1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in lipid catabolism. Essential for sterol esters biosynthesis in leaves and seeds, but not in flowers. Plays a role in controlling the free sterol content of leaves. Catalyzes the transacylation of acyl groups from phospholipids to a variety of different sterols. Prefers phosphatidylethanolamine over phosphatidylcholine as an acyl donor. Not active toward neutral lipids. Highly specific for position sn-2, which in plant lipids is essentially devoid of saturated acyl groups. Broad sterol specificity (cholesterol > campesterol > sitosterol > stigmasterol), but no activity with lupeol or beta-amyrin.
Subcellular location: Microsome membrane {ECO:0000269|PubMed:16020547}; Single-pass type II membrane protein {ECO:0000269|PubMed:16020547}.
Interaction partners:
- Acyl-CoA--sterol O-acyltransferase 1
- Ternary complex factor MIP1 leucine-zipper protein
- LIMR family protein At5g01460
- Putative RRM-containing protein family protein)
- U11/U12 small nuclear ribonucleoprotein 59 kDa protein
- Protein OXIDATIVE STRESS 3 LIKE 4
- Protein RALF-like 31
- Elongator complex protein 5
- Nuclear polyadenylated RNA-binding protein
- Protein OXIDATIVE STRESS 3 LIKE 3
Sequence:
MGANSKSVTASFTVIAVFFLICGGRTAVEDETEFHGDYSKLSGIIIPGFASTQLRAWSILDCPYTPLDFNPLDLVWLDTTKLLSAVNCWFKCMVLDPYNQTDHPECKSRPDSGLSAITELDPGYITGPLSTVWKEWLKWCVEFGIEANAIVAVPYDWRLSPTKLEERDLYFHKLKLTFETALKLRGGPSIVFAHSMGNNVFRYFLEWLRLEIAPKHYLKWLDQHIHAYFAVGAPLLGSVEAIKSTLSGVTFGLPVSEGTARLLSNSFASSLWLMPFSKNCKGDNTFWTHFSGGAAKKDKRVYHCDEEEYQSKYSGWPTNIINIEIPSTSVTETALVNMTSMECGLPTLLSFTARELADGTLFKAIEDYDPDSKRMLHQLKKLYHDDPVFNPLTPWERPPIKNVFCIYGAHLKTEVGYYFAPSGKPYPDNWIITDIIYETEGSLVSRSGTVVDGNAGPITGDETVPYHSLSWCKNWLGPKVNITMAPQPEHDGSDVHVELNVDHEHGSDIIANMTKAPRVKYITFYEDSESIPGKRTAVWELDKTNHRNIVRSPVLMRELWLQMWHDIQPGAKSKFVTKAKRGPLRDADCYWDYGKACCAWQEYCEYRYSFGDVHLGQSCRLRNTSANMLLQYI
Protein: Wilms tumor protein 1-interacting protein homolog (WT1-interacting protein homolog) (A8DZE6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development (By similarity).
Subcellular location: Cell junction, adherens junction {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Ajuba LIM protein
- M-phase phosphoprotein 6
- Protein KIBRA
Sequence:
MDEYDEDPGRRASKLMETLSIYDVYQDGMYGEPNPDMEKTKRMNGSSSTPGNKVYSAAPVRSVNGNRASVPLDFCSPQREAVYPDPDVYCTKSEVALPCYSGASDRLRRYTHAEVQGHRYSTGCAYDGLVLGKQVAVSGARSNSLCMSSPDGRYTATSPRSSLASSHSSQDQSKHTSPRSSISSPRSSLVSPGQGEGTSVISPRSSYASTASDTSKHSSPRTSLNSYDCGSKPSSNRTSGISMGYDQRHISPRSSTTSPRSSYSDSRFTPAGGHDPESAAVHGIPMASPRSSICSQPAVAANCVVSPRSSISSHSSRSSRSSRGSMSAYPELQLPMLGPGLPEDALLQDFTEPNGLHNNRVHLQTFPVLEEPQQQNSEVNIGFNYCKAGAGGQRFKLPYQVTPSRDSGPSQAERRLEALTLELEKELEIHMKKEYFGICVKCGKGVYGASQACQAMGNLYHTNCFTCCSCGRRLRGKAFYNVNGKVYCEEDFLYSGFQQTAEKCFVCGHLIMEMILQALGRSYHPGCFRCVICKEGLDGVPFTVDVENNIYCVKDYHTVFAPKCASCNQPILPAQGSEETIRVVSMDKDYHVDCYHCEDCGLQLNDEEGHRCYPLEGHLLCHRCHLHRLKTPLAPHPPPSYPLHVTEL
Protein: SUMO-activating enzyme subunit 1B-1 (SUMO-activating enzyme subunit 1-2) (Ubiquitin-like 1-activating enzyme E1A) (P0DI12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Functionally redundant with its paralog SAE1A.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SUMO-conjugating enzyme SCE1
- SUMO-activating enzyme subunit 2
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 5
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 3
- SUMO-activating enzyme subunit 1A
- Putative small ubiquitin-related modifier 4
- Putative small ubiquitin-related modifier 6
- E4 SUMO-protein ligase PIAL1
Sequence:
MDGDELTEQETALYDRQIRVWGAGAQRRLSKSHVLVSGIKGTVAEFCKNIVLAGVGSVTLLDDRLVTTEVFNANFLILPDENAYVGKTVAEICCDSLKDFNPMVHVSIEKGDLSTLGVDFFEKFDVVVIGYSSRATKKAVNEKCRNLAKDVAFYTVDCRGSCGEIFVDLQNYKYTKKKLDETVECELTFPSFEEAVSVPWKPMPRRTAKLYFAMRVIELFEETEGRKPGECSLSDLPRVLKLKKELCEGNSVSENHIPDILLERLVSNNTEFPPACAIIGGILGQEVIKVISGKGEPLKNFFYFDAEDGKGVIEDLSHKL
Protein: Cerebellin-4 (Cerebellin-like glycoprotein 1) (Q9NTU7)
Organism: Homo sapiens (Human)
Function: Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for the formation and maintenance of inhibitory GABAergic synapses (By similarity). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (By similarity). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (By similarity). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8BME9}. Synapse {ECO:0000250|UniProtKB:Q8BME9}. Note=Detected at GABAergic synapses. {ECO:0000250|UniProtKB:Q8BME9}.
Interaction partners:
Sequence:
MGSGRRALSAVPAVLLVLTLPGLPVWAQNDTEPIVLEGKCLVVCDSNPATDSKGSSSSPLGISVRAANSKVAFSAVRSTNHEPSEMSNKTRIIYFDQILVNVGNFFTLESVFVAPRKGIYSFSFHVIKVYQSQTIQVNLMLNGKPVISAFAGDKDVTREAATNGVLLYLDKEDKVYLKLEKGNLVGGWQYSTFSGFLVFPL
Protein: Heat shock 70kDa protein (Q5KT35)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MSSAKGPSIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPNNTVFDAKRLIGRKFNDQVVQADMKHWPFKVVSDGGKPKVQVDYKGENKSFNPEEISSMVLVKMREIAEAYLGQKVSNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGMDKGKSRERNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRALRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTSITRARFEEMCSDLFRGTLEPVEKALRDAKMDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGRELNKSINPDEAVAYGAAIQAAILSGDKSENVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPSKQTQIFTTYSDNQPGVMIQVYEGERAMTKDNNLLGKFELSGIPPSPRGVPQIEVTFDIDANGILNVAAVDKSTGKENKITITNDKGRLSKEDIERMVQDADKYKAEDDAQREKMAAKNSLESYAFNMKSSVEDDNMKGKISEEDKKKVMDRCNQTISWLENNQLGDKEEYEHQLKELEKVCQPIITKLYQQGGMPTGCCGDQARTSSGVSSQGPTIEEID
Protein: Homeobox protein DBX2 (Developing brain homeobox protein 2) (Q6ZNG2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MLPSAVAAHAGAYWDVVASSALLNLPAAPGFGNLGKSFLIENLLRVGGAPTPRLQPPAPHDPATALATAGAQLRPLPASPVPLKLCPAAEQVSPAGAPYGTRWAFQVLSPSADSARLPGRAPGDRDCTFQPSAPAPSKPFLLSTPPFYSACCGGSCRRPASSTAFPREESMLPLLTQDSNSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCIQEVGLQEDPLSRSALGFPSPCPSIWDVPQQHSSPRWRENSPEPSERLIQESSGAPPPEANSLQGALYLCSEEEAGSKGVLTGAV
Protein: phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (H0YM31)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGGASKSGAEEWTQSSNGRDGLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVPLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGLLGTGGS
Protein: G protein-coupled receptor 137Ba (E7F594)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Acts also as a negative regulator of osteoclast activity. May be involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:O60478}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MQKDSLPTLSPAVPPYVMLGLTVAYTIFYCLLFVFVYVQLWLVLRYRHKRFSYQTVFLFLCLLWAALRALLFSFYFKNCVTANTLGPFCFWLLYCFPVCLQFFTLSLMNLYFAQVIFKAKSKYSPELQKYRLPLYLLFLSISLLFLLVNLTCALLVKINRANTETVVLVRVTVNDSLFVLCAVSLSLCLYRIAKMSLANIYLEAKGTSVCQVTLIGVTVVLLYSSRACYNLVVLALTKIKSINSFDYDWYNVSDQADLKSTLGDAGYVVFGVILFVWELLPTSLVVYFFRVRKPTLDRSASVIPGHMFSSRAYFFDNPRRYDSDDDLAWSIIPQNIQASFTSDSYDWSCRNNSFTAYTEAEESHLAPEELNPY
Protein: Methyltransferase (EC 2.1.1.-) (Q4FKJ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- C-8 sterol isomerase, putative
- Lanosterol 14-alpha-demethylase
- squalene synthase
- NAD
- Lanosterol synthase
- C-5 sterol desaturase, putative
- Lathosterol oxidase, putative
- Delta
Sequence:
MSAGSRGPLSLLIARERDANGVNGDVNATAGRLRDRYDGKGASASERRQDATSLTNEYYDIVTDFYEYGWGQNFHFAPRYMNETFYESLARYEYFLAYHAQFKPTDTVLDVGCGIGGPARNMVRFTSCNVMGVNNNEYQINRARQHDSRYGMSGKINYTKTDFCNMCFGDNEFDGAYAIEATCHSESKVKCYSEVFRAIKPGAYFMLYEWCLTDLYDPANEEHQRVRHGIELGDGLPELDTMRQVVAAVKAAGFVVEESFDMAERFESGEPKSVPWYEPLQGSYTSLSGLRATPAGRWLTSVTCRLLEAVRLAPAGTCKATEILEEGAVNLVKGGELGIFTPSFFVKARKPRLGEELSC