wanglab/gogpt-training-data huggingface dataset:
Protein: Coatomer subunit delta (Q57UJ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}; Peripheral membrane protein {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}; Cytoplasmic side {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}; Peripheral membrane protein {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}; Cytoplasmic side {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}.
Interaction partners:
- Coatomer subunit gamma
- Coatomer subunit zeta
- Coatomer subunit beta
- Coatomer subunit beta'
- Coatomer subunit alpha
- Coatomer subunit epsilon
- ADP-ribosylation factor GTPase activating protein, putative
- Cytosolic coat protein, putative
- COP-coated vesicle membrane protein erv25, putative
- ER lumen protein-retaining receptor
Sequence:
MTVIVAGIVNKQGGIVLSRHFNDITRVRVEGLLSAFPRLMEASTNKQVTYVDAGAVRYVYQPLDDLFLVLITTRSSNIVEDLDTLHLMGRLITEHVGTVSEVFLQEKAFKVFFALDEVIVGGRRENTTTEQIQTYLEMQSHEEMMVREEKRLQMERAKKDASRKAHELRDKRQRGLNPYTGIGSDSVGYGSGGAAVSVSRPAAEASSRIDTMDELGPTRIAGMASGSADSLSGRKVGRGGGLALGVARKADITSRVLQEAGLPVGAVATKLPVGDAGAAAKAPEFDGPIEGIHVVVEEKISATLDRDGASGPVDVRGELSVLVNDPHLANVKLMLSPTSDEFSFRAHAKVHKEIFAEDRVLAMRENKPFPVHQPVTILRWRLNNSSGVQPPLTFSCWPNAGSITVEYEISNADLVEQGLCDVRVTLPLRGAVAATVESTTGSCSTQEDCVVWQIPQVSNHVNASGNCEVVLADPDCAASGADEVFFPVDVTFKTRATAAHVRVLEVVQTENGVPVKFTQETQLTAEGYNVQ
Protein: Homeobox protein Hox-A5 (Homeobox protein Hox-1.3) (Homeobox protein M2) (P09021)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-A3
- Homeobox protein Hox-A2
- Homeobox protein Hox-D10
- Homeobox protein Meis1
- Homeobox protein Hox-B4
- Histone deacetylase 8
- Homeobox protein Hox-B5
Sequence:
MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSGSGHFGSGERARSYAAGASAAPAEPRYSQPATSTHSPPPDPLPCSAVAPSPGSDSHHGGKNSLGNSSGASANAGSTHISSREGVGTASAAEEDAPASSEQAGAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP
Protein: Histidine decarboxylase (HDC) (EC 4.1.1.22) (Q05733)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required in photoreceptor transmitter synthesis. Catlayzes the conversion of L-histidine to histamine (Probable).
Interaction partners:
- Carnosine dipeptidase 2, isoform A
- Histamine-gated chloride channel subunit 1
- Carcinine transporter
- Histamine-gated chloride channel alpha1 subunit
- Loss of visual transmission
- Beta-alanyl-bioamine nonribosomal peptide synthetase ebony
Sequence:
MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVHRTFNVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDDIVKDWMEIRQVASTVLEEMNITISNRVYLKETKEKNEAFGSSLLLSNSPLSPKVVNGSFAAIFDADEFLAKTYAGVRIAHQESPSMRRRVRGILMSGKQFSLDSHMDVVVQTTLDAGNGATRTSTTNSYGHTTSAAQANSERQASIQEDNEESPEETELLSLCRTSNVPSPEHAHSLSTPSRSCSSSSHSLIHSLTQSSPRSSPVNQFRPITLCAVPSQSQLSMPLAMPLPNRNVTVSVDSLLNPVTTCNVYHGKRFLEPLENLAQTSASFSSSIFRLPTPIATPTRESPEDPDWPAKTFSQLLLERYSSQSQSLGNNSSTESSSLSGGATPTPTPMSSLDELVTPLLLSFASPSQPMLSAHGIGEGQREQGSDSDATVCSTTSSMESL
Protein: Heat shock protein 67B1 (P05812)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heat shock protein 67B3
- Heat shock protein 68
- Heat shock protein 83
- Heat shock 70 kDa protein cognate 2
- Major heat shock 70 kDa protein Ba
- Major heat shock 70 kDa protein Aa
Sequence:
MSLIPFILDLAEELHDFNRSLAMDIDDSAGFGLYPLEATSQLPQLSRGLGRGNAMMWVPIKGQSAASQHRHHPYNRVAGAKTACCNKSLVELEKELGDKGTSGASGSTSGQPAASKSAYSVVNRNGFQVSMNVKQFAANELTVKTIDNCIVVEGQHDEKEDGHGVISRHFIRKYILPKGYDPNEVHSTLSSDGILTVKAPPPLPVVKGSLERQERIVDIQQISQQQKDKDAQPPKPSEVEQQAAASATTSTLNPTAPTPTPSLSLTLAESNGNGQEETEMEMPAVSPPISNEAAAAAAVAVEAPSTAGTTSSANNGVAEPESESMEVALAKNEETANVDEPTPNPVISIEEEQKAEDANANEVPVASNNGNGAVAAAEDVEMPLAKKPEISTEDSKEEQAEKVDKVEKVEEKGGEELAAVDAAILLAKNQGENGATAAKTEELAK
Protein: D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39) (Q8N465)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:15070399}.
Interaction partners:
- L-2-hydroxyglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- DNA methyltransferase 1-associated protein 1
- Transformation/transcription domain-associated protein
- Methionine adenosyltransferase 2 subunit beta
- Chromatin modification-related protein MEAF6
Sequence:
MLPRRPLAWPAWLLRGAPGAAGSWGRPVGPLARRGCCSAPGTPEVPLTRERYPVRRLPFSTVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQAGCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLADGTVLDCLTSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCKGMLGEILSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA
Protein: RE38567p (Q8IGS0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQSSTDAGNGGPRKHTQSTAPQKQSEISETTSFTVNANTTTNSQQQQIPGGPASNTPSKNPFKQQLDSNQQNGNMEPDCGIMGVGKEPPVPPPPTYQSQTYAGRQAPPPADQYREEDPRAAGSWAAAKSWMVSWRGSNRLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLDSFPRTPLTSNVPPPPTPCPCNKDGSEAAPLEISTISPEENETYYRELEERHNELVGETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGLALGVLIGPPFGGVMYEFVGKSAPFLILAALALGDGLLQLFMLQPSIQKAETEPPSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFEWMLFGIAILCFMYAPLLTLLRNPPTSDEKKSLIYGRDRAQVRYVTYQNYEEDE
Protein: C-C motif chemokine 4 (Immune activation protein 2) (ACT-2) (ACT2) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (P14097)
Organism: Mus musculus (Mouse)
Function: Monokine with inflammatory and chemokinetic properties.
Subcellular location: Secreted.
Interaction partners:
- C-C chemokine receptor type 5
- C-C chemokine receptor type 1
- C-C chemokine receptor type 2
- C-C motif chemokine 3
- Probable C-C chemokine receptor type 3
- C-X-C chemokine receptor type 3
- C-C chemokine receptor type 7
- C-C motif chemokine 2
- C-X-C chemokine receptor type 4
- C-X-C motif chemokine 10
Sequence:
MKLCVSALSLLLLVAAFCAPGFSAPMGSDPPTSCCFSYTSRQLHRSFVMDYYETSSLCSKPAVVFLTKRGRQICANPSEPWVTEYMSDLELN
Protein: BZIP domain-containing protein (Q57Z04)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSMSNGSSGSFIDHGPKADYRDGSRPQWIVDKTVSKRDFNAEGARDHSSGNSLRSSTGSEMSDVSPMRGKLSVDVEGVVSALCRERKKTKRLLRDKRRLEGEVIGLKRENTSLLECNRLLAEHNSSLAASVTTLVMKHDQTQFAVTSLASQTQEIGVTVKMLYEKTAVK
Protein: Ras-related protein RABG3e (AtRABG3e) (Ras-related protein Rab74) (AtRab74) (Q9XI98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport. May play a role in adaptation to stress by recylcing macromolecules in specific cellular compartments.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Protein VACUOLELESS1
- Vacuolar sorting protein 18
- Vacuolar protein-sorting-associated protein 33 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar fusion protein MON1 homolog
- Guanosine nucleotide diphosphate dissociation inhibitor 2
- Guanosine nucleotide diphosphate dissociation inhibitor 1
- Guanosine nucleotide diphosphate dissociation inhibitor At5g09550
- Vacuolar fusion protein CCZ1 homolog B
Sequence:
MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSAKSFEDLNNWREEFLIQASPSDPENFPFVVIGNKIDVDGGSSRVVSEKKARAWCASKGNIPYYETSAKVGTNVEDAFLCITTNAMKSGEEEEMYLPDTIDVGTSNPQRSTGCEC
Protein: Coiled-coil domain-containing protein 22 (O60826)
Organism: Homo sapiens (Human)
Function: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.
Subcellular location: Endosome {ECO:0000305|PubMed:28892079}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}.
Interaction partners:
- Coiled-coil domain-containing protein 93
- VPS35 endosomal protein-sorting factor-like
- COMM domain-containing protein 1
- COMM domain-containing protein 8
- COMM domain-containing protein 2
- Vacuolar protein sorting-associated protein 26C
- COMM domain-containing protein 4
- COMM domain-containing protein 3
- COMM domain-containing protein 10
- COMM domain-containing protein 6
Sequence:
MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPAGDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEPREFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVREA
Protein: Protein NAG1 (Nested antisense gene 1 protein) (Q8TGN9)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in yeast cell wall biogenesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Localizes to the cell periphery under conditions of vegetative growth. {ECO:0000269|PubMed:18310357}.
Interaction partners:
- Probable alcohol acetyltransferase
Sequence:
MNSAGRVHRSRAGSRGHAAISPLTMASFSVARGIRSSNVYDDTDDELSILTFFSAVRRNRLTSSLPPILSARCSSACFSVRIVLPLSLTISISALMYSTNSALGRKLTGAFSIQTNIEQSCGFFRTSIMATLPPIECPIIIGPPLVFNSCFVIKCFTSSDMTS
Protein: Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) (P04921)
Organism: Homo sapiens (Human)
Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Subcellular location: Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
Interaction partners:
- Protein 4.1
- Glycophorin-B
- Glycophorin-A
- HLA class I histocompatibility antigen, A alpha chain
- 55 kDa erythrocyte membrane protein
- Glycophorin-E
- Beta-adducin
- Alpha-adducin
- Dematin
- Gamma-adducin
Sequence:
MWSTRSPNSTAWPLSLEPDPGMASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI
Protein: Ornithine decarboxylase (ODC) (EC 4.1.1.17) (P11926)
Organism: Homo sapiens (Human)
Function: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Interaction partners:
- Ornithine decarboxylase antizyme 1
- Spermidine synthase
- Ornithine decarboxylase antizyme 3
- Arginase-2, mitochondrial
- Guanidino acid hydrolase, mitochondrial
- Ornithine aminotransferase, mitochondrial
- Diamine acetyltransferase 1
- Arginase-1
- Spermine synthase
- Ornithine decarboxylase antizyme 2
Sequence:
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
Protein: Sidestep, isoform A (Q9VB35)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MQLLLPTSGMPTNTLETETPAMQTTYWPRQTGNSKSKSNTNCKCNINTHRKSRTRCPDNGKTIWAVGFTLVLLTCLQQLKSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFREGYELFLCCQVRGGRPPPKVTWWRDDTELIGTSHTSVEEGATVMVNQLLIGTTTRDFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCESWGSYPAAKITWLLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSENDNAELTCRATNPWFSGGAIEDKRIIRVAYPPTVSVHLANEDPSRLVTRAEGQNVTFKCRADARPPVTSYSWFKNGMRMSGESTEIMHLTQLERESAGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAVSLHSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSELITLACWASNAVGRQTTPCLVHILPANTPEAPKACELRNDTVLEVVCVAGSDGGLSQYFMLEVVGGDPLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSAPIFRMQENSPQFRLNNLEPGREYQFLVYAVNAKGRSEPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGGVGGSGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTSIIVAGIVVVCRHRPRPPEPQEVRKSMRPARNDVPSMYIEEDELNELEEGGGRAADIRARVAPPNSHLCGGGGMPMPGGVGSSGGAIVGVAGPHHYISESFIQYAQPSLNDPDLILPRGELEFTTLDPTLK
Protein: [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) (A0A8I6ADI5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKSCGVSLATAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEEYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQLENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQNTSDNWSGGNAVPHPPVQQQTHSWCLTPQKLQMRQTGVAQVRPTGIPNGPTADSSLPTNSASGQQPQLPLTRMPSVSQPGVQPACPRQALANGPFSAGHVPCSTSRTLGSTDTILIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGQSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTLPETNRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDIVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSVSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKRRRGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMVKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCAWKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS
Protein: E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein) (Q8WU17)
Organism: Homo sapiens (Human)
Function: E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.
Interaction partners:
- Signal peptide peptidase
- Protein sel-1 homolog 1
- Usherin
- Derlin-1
- Protein OS-9
- Insulin-induced gene 1 protein
- E3 ubiquitin-protein ligase AMFR
- Ubiquitin-conjugating enzyme E2 G2
- Transitional endoplasmic reticulum ATPase
- Insulin-induced gene 2 protein
Sequence:
MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDSSQSRFCIVLQIFLRLFGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRERNGVIQHTGAAAEEFNDDTD
Protein: Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93) (Q9H1C0)
Organism: Homo sapiens (Human)
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor 3
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 6
- Guanine nucleotide-binding protein subunit alpha-13
- Proteinase-activated receptor 1
Sequence:
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
Protein: Uncharacterized protein (Q384H9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIRLSEVVRRVLLHASGGRSCRSFRNGCGVENDHENGNADLLSLRSTLPNQNDFFFSRSSASNCCRLCGEVSQTILSHTGSQAHVTVEALMWLLFQRARQYKDGAVGVSPTAARNFFVEEARRWEGILQCSLVNQRSSSLHAITEDGSPCLEESAVYHGDPATLWKEVAEKSALRLQSQIRVLGKLGVLNVVDSLFTTASSGGLQRDAAFQRMECIGDHNWGHSVCRRIVLLFPEVNWRANSNVLVMDALRTVLECNQHLVHVFTLLQLSDKLGGRDVKEKSVKFKADIVEAIIGELHVALWSLQSSTNDGFTSIPSIHGAPYTIPLVSMVEECLDGIVGLVILALMARYAASLVPAVVDLVRREKYLLDVSCPFYTLRKRRERFRQDEHAMRWLLPPHPPLQQQRQELLKGPRSSVDTCVNEWNLSNTNPVGDVLANASGGENMALTNAMEKRTPTGVVCWTKKIFFSEMADFYGLLRLPGGQPP
Protein: Prominin-like protein (P82295)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGEVAATVEPLAAVKSKSMRSRKRRQRRRRQIAYLAICGLSVAIFGFALATLIRPTTAQADADPGSWRKGYVGHGTTHEQLGQPHWPPVQYTVYRPTTNYTKAPPPPTSAMNPIFNFTHFLYDKVLYRDEPIPEGYIVVKNSDTLSLGPKVEENDWRDLLAHYWMVLIWVVILVVLIIVIPFIAVCYCCFCCCRRCRQGCPPCTSKQDAQRRFCCGICLLILIIGLIFGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMYNYEEMETHVLDQLTHAHRHIFLDLSDTSESNSLAEMERVLENMPEALELMRQVEKMEKDLRFYGSQLRDGVRGIKRDVNFAVANLCQLQMCQKFLISSNIEHIDSSQCLHFDNLPNTKEFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLTKGRTIFREHATNVRNIVEGVLSDIHIKTLHSTKSFEDVYERFGHDRNVVSLIVCLLILLVLFILIFALLCGCFGRRRTGYGDECCSKSTGATCLLLAILLIFCVFSFIALVGLFYFMLGMVTYQGACAPLRDQENNTLFRQLDASIDLNHYLPPSESNKEVVQPLKMSSAIKACHANQTIFDMMRQHNIYDINDLTRIKVMSHSQENTDSIKVFDEDLSTVVLLTKEERDELKTAGESKLAKYHSSLYMPSLCTQFTPMNLNALSEQLYKLSNDLEYPAYGWAKVSFWNEGLNTKAFYRNFVPKLTSLVEKMKANLKKIDELISYENHDFTNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSYIYYRGVDLICHRIVDPINGFWVGILLCALLFLPILFVAHRLMCLYKKIYPYLATVGAAGVVEGGSDYLYDAYSERDREHVPLANVPKKRRKAYERRREQQDYFEDASPSVSRGNRSGGDRGGGGGDGAPGSSSMRYNDMAPTHWDHEPPRYHNPPAAPPSSEYERPPPYYYPGASEQD
Protein: Mitochondrial import inner membrane translocase subunit Tim16 (Protein black pearl) (Q9VF08)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix (By similarity). Essential for larval development.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM14
- SD19278p
- GEO10507p1
- Reactive oxygen species modulator 1
- GrpE protein homolog, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim21
- Translocase of the inner mitochondrial membrane 17b, isoform A
- MIP34364p1
- Probable mitochondrial import inner membrane translocase subunit Tim17 3
Sequence:
MAKYIAQIIVLGAQAVGRAFTKALRQEIAASQEAARRAGGGKQGDKSAESNLRTGMTLEEAKQILNIDDPKNVDAITKNYEHLFQVNERSKGGSFYIQSKVFRAKERLDHEIKAHEQPRSSNTEAAQDTAEESQSRSRQRR