wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform) (Q99259)
Organism: Homo sapiens (Human)
Function: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
Interaction partners:
- Vesicular inhibitory amino acid transporter
- 4-aminobutyrate aminotransferase, mitochondrial
- Glutamate decarboxylase 2
- Parvalbumin alpha
- Methyl-CpG-binding protein 2
- Glutamate dehydrogenase 2, mitochondrial
- Glutamine synthetase
- Glutamate dehydrogenase 1, mitochondrial
- Glutaminase liver isoform, mitochondrial
- Glutaminase kidney isoform, mitochondrial
Sequence:
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
Protein: LD16137p (Q95RQ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVAQQQHSEIIYEELPTDYSGHIEASEEECVTTATDATVAKRPKYVSEVL
Protein: GTPase IMAP family member 1 (Immune-associated protein 38) (IAP38) (Immunity-associated protein 1) (P70224)
Organism: Mus musculus (Mouse)
Function: May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11814688, ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- GTPase IMAP family member 6
- GTPase IMAP family member 8
- GTPase IMAP family member 5
Sequence:
MPQLRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPRTDPGCVETARCFVLSAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDNRALRDLVAECGGRVCALNNRATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQDTRCADPQDQVAKVAEIVAERMQRRTRLLAGLWGWRKFYWKGWRRGFSVFLGVAILIYLLFYRKGFGDQNNR
Protein: Ephrin type-B receptor (F4JXY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine carboxypeptidase-like 51
- Dual specificity phosphatase Cdc25
Sequence:
MARFQFCCVFVLVALAVLAVNPSSSYRFTIVEPKSGSDSDLDSDSESLLFHQDYSPPAPPPPPPHGPSVSCSEDLGGVGFLDTTCKIVADLNLTHDVYIAGKGNFIILPGVRFHCPIPGCSIAINVSGNFSLGAESTIVAGTLELTAGNASFANGSAVNTTGLAGSPPPQTSGTPQGIDGAGGGHGGRGACCLTDTKKLPEDVWGGDAYSWSTLQKPWSYGSKGGSTSREIDYGGGGGGKVKMDILQLLDVNGSLLANGGYGGAKGGGGSGGSIYIKAYKMTGIGKISACGGSGYGGGGGGRVSVDIFSRHDDPKIFVHGGYSIGCPDNSGAAGTLYDAVPRSLFVSNYNQTTDTYTLLLEFPFQPLWTNVYIQDKARATCPLLWSRVQVQGQISLLCGGVLSFGLAHYGTSVFELLAEELLMSDSTIKVYGALRMTVKMFLMWNSELHLDGGGGDTTVSTSMLEASNLFVLRGSSVIRSNANLGVHGQGFLNLTGPGDSIEAQRLVLSLFYRIYVGPGSILRAPLLNASRDAVTPKLYCERQDCPYELLNPPEDCNVNASLSFTLQICRVEDILVEGFIKGSVVHFHRAKTVTLEPSGEISASGMGCRGGVGEGKLLGNGFGSGGGHGGKGGRVCYNNSCVEGGITYGNANLPCELGSGSGDFSPGYSSAGGGIVVIGSMEQPLSGLSLEGSIRVDGESVKRLSRDENGSIVAPGGGSGGTVLLFLRYLILGESSLLSSGGGSGSPGGGGGGGGGRIHFHWSNIPTGDIYQPIASVKGIIHARGGAAADDGFYGKNGTITGTACPKGLHGIFCKECPSGTFKNVTGSDPSLCRPCPVDELPTRAVYVTVRGGVSETPCPYRCISERYHMPHCYTALEELIYTFGGPWLFGLLLMGLLILLALVLSVARMKFVGVDDLPGPAPTQHGSQIDHSFPFLESLNEVLETNRAEQSQSHVHRMYFMGPNTFSEPWHLSHIPPEEIKEIVYEAAFNTFVDEINSIAAYQWWEGAIYSILSVVAYPLAWSWQQWRRKMKLQKLREFVRSEYDHSCLRSCRSRALYEGLKVAATSDLMLAYLDFFLGGDEKRTDLPPRLHQRFPMPILFGGDGSYMAPFSLQNDNILTSLMSQLGSPTTWYRLVAGVNAQLRLVRRGRLRSTFHSVLRWLETHANPALETHGIRVDLAWFQTTACGYCQYGLLIHTVEDCEPTSPQCVSETTWTEIQPRYGVNAHKENSPPHLRESRLFNQPHSNTEDYTTRRKNYGGIIDLDSLPSLKEKRDMFFLLSFLVHNTKPVGHQDMVGLVISMLLLGDFSLVLLTLLQLYSISLLDVLLALFILPLGLLLPFPAGINALFSHGPRRSAGLARVYALWNFMSLVNVFVAFLCGYVHYHSESSASKKIPFQPWNINMGESEWWIFPAGLVVCKIMQSQLINRHVANLEIQDRSLYSKDYELFWQS
Protein: Chaperonin 60 subunit beta 1, chloroplastic (CPN-60 beta 1) (60 kDa chaperonin subunit beta 1) (RuBisCO large subunit-binding protein subunit beta, chloroplastic) (P21240)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds RuBisCO small and large subunits and is implicated in the assembly of the enzyme oligomer. Involved in protein assisted folding. Required for proper plastid division.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:19344532}.
Interaction partners:
- 20 kDa chaperonin, chloroplastic
- 10 kDa chaperonin 2, chloroplastic
- 10 kDa chaperonin 1
- 10 kDa chaperonin, mitochondrial
- Heat shock 70 kDa protein 6, chloroplastic
- Heat shock 70 kDa protein 7, chloroplastic
- Chaperonin 60 subunit alpha 1, chloroplastic
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 10, mitochondrial
- Heat shock 70 kDa protein 9, mitochondrial
Sequence:
MASTFTATSSIGSMVAPNGHKSDKKLISKLSSSSFGRRQSVCPRPRRSSSAIVCAAKELHFNKDGTTIRRLQAGVNKLADLVGVTLGPKGRNVVLESKYGSPRIVNDGVTVAREVELEDPVENIGAKLVRQAAAKTNDLAGDGTTTSVVLAQGFIAEGVKVVAAGANPVLITRGIEKTAKALVTELKKMSKEVEDSELADVAAVSAGNNDEIGNMIAEAMSKVGRKGVVTLEEGKSAENNLYVVEGMQFDRGYISPYFVTDSEKMSVEFDNCKLLLVDKKITNARDLVGVLEDAIRGGYPILIIAEDIEQEALATLVVNKLRGTLKIAALRAPGFGERKSQYLDDIAILTGATVIREEVGLSLDKAGKEVLGNASKVVLTKETSTIVGDGSTQDAVKKRVTQIKNLIEQAEQDYEKEKLNERIAKLSGGVAVIQVGAQTETELKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVDAIKATLDNDEEKVGADIVKRALSYPLKLIAKNAGVNGSVVSEKVLSNDNVKFGYNAATGKYEDLMAAGIIDPTKVVRCCLEHAASVAKTFLMSDCVVVEIKEPEPVPVGNPMDNSGYGY
Protein: Sec1/munc18-like (SM) proteins superfamily (F4JE40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAQIPSLENAPLNLKSIRDKSERELVNLLKDVRGTKCLVIDPKLSGSVSLIIPTSKLKELGLELRHLTAEPVQTECTKVVYLVRSQLSFMKFIASHIQNDIAKAIQRDYYVYFVPRRSVACEKILEQEKVHNLVTVKEFPLYMVPLDEDVISFELELSEKDCLVDGDVSSLWHIAKAIHELEFSFGVISKMRAKGKASVRVADILNRMQVEEPVNSNDVGRPEVDTLILLDREVDMVTPMCSQLTYEGLIDEILHISNGAVEVDSSVMGAQQEGKKMKVPLNSSKYDAWNIYFDFRGLDNDKLFKETRDLNFEVVVQVLRQKAMTMKEDYTEINSTQTVSELKDFVKKLNSLPEMTRHIHLAQHLTTFTSKQSFNSQLDMEQTLVEAENYDICYEYIEEMIHKQEPLTNVLRLLVLFSVTNSGLPKKQFDYIRMELLHSYGFEHVVTLNNLEKAGLLKKQEFKSNWLTVKRTLKLIVEDTDTSRPNDIAYVYSGYAPLSIRLIQQAIHSGWRPMEDILKLLPGPHLETKRSGFPSSPSVDSLHGASNGVADGRRSIVLVVFIGGVTFAEISALRYLASKEGMAYDLIVATTKIVNGATLIETFMEKLG
Protein: AT31403p (Q8T3U9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTNNVNECKSLWNGIISISAKDESPKGLTEMCNHPIRRVPQKCKPIKSCAKPRRKAACAKATRPKVKCAPRQKCSKQGPVTNNAYLNFVRSFRKKHCNLKPRELIAKAAKAWARLSENRKDRYRRMACKVTTSERHKRRRICQQN
Protein: Chondroitin hydrolase (EC 3.2.1.-) (G5ECE8)
Organism: Caenorhabditis elegans
Interaction partners:
- Beta-glucuronidase
- VWFA domain-containing protein
Sequence:
MVIVWYHQLLLVLLIFIGAAKGAQYIGSGASQPNRTDVVWMVPSWTCKNEYSIDVEKYGILQNEDQHFVGGKQFAIFYEHSFGKIPYFKAQNESDPKNGGLPQMGDLEAHLIQAEKDINETIPDENFNGIAVIDIEEFRPMWELSWGPFSVYKTESIRLTRQQHPYWSTKQIEWQAERDYEKACQKFFIETLRLGKRLRPNAKWGYYLFPKCNGDVGQKSDTDCSTLFQKFNDNLHWLWGESTALFPSIYLYPSQKQNPEYNFVNSGALITETKRIKRNYCPSCEIHVFTKIEYNPYYTPDDFYSKQNLASTLDLAIKMNANSVVIWSTSQSIGSRCGSLQTYVDNTLGPYLQLTDRNLDKCRMERCEGRGECYLPRPKTNPAIYNFACRCERPYFGKSCEYRGRRMGVSMPKASQTPQVIPDVTAYFSTSSNGTKKYNAPNQFYSRTGGDIKLARKL
Protein: Rubicon Homology domain-containing protein (Q38BR7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTEVAVDCFPTPTVSSHSLSNEVNNNGRGGVSSGGMVAVEDKVALLLAGARKLLEEPTPSLSCHAEEVLPCDDEEECRRRLRFLEAAHAFVEQQHVTQRYLKRAVVSSRSIGVNAWTSEQTRGGLPHCSARDLPAVAVMIDGELTDCETEECPTRHNLCFSTVLHIKPRGLWAKDAAVRRQGQYCKQCLDPLHRYKIPLPVWKEARFCYFTGMYYCNMCNSSRYSVIPAFVLKKWDFKPRPVCNDAYEFLKYHHKHPIYRVCALNPRLYERVALLRVARNLRSQLMKLRDVGMKCAVLRHLLYLHDAPVELERDSNRRPSRTTTNASATNHVATFVASDGDAASFAADCYVPRTRRYLLENCELWSLSDLEDVRRGQLLFRQESAGRTMAFIKDTSLISQLAAYSKGTAALCGECDTTVYLKQVRSRILRHILVHSCATCLVNSVDVCSICCPAEVAQKLECINEQTRGGTPFGTCEHFFGSLIKDVSVLPFLVYVFDTLHVFCCTGCGSAYHRRCFKEMQHTKGDLTCCPRCRATQLIKE
Protein: Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)] (P10720)
Organism: Homo sapiens (Human)
Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).
Subcellular location: Secreted.
Interaction partners:
- C-X-C motif chemokine 10
- C-X-C motif chemokine 13
- C-X-C motif chemokine 11
- C-X-C chemokine receptor type 3
- Stromal cell-derived factor 1
- C-C motif chemokine 21
- C-C motif chemokine 22
- Cytokine SCM-1 beta
- Eotaxin
- Lymphotactin
Sequence:
MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES
Protein: DUF423 domain-containing protein (Q384F5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGRIGDTPMIIIGLLGFMGVAAAAIGAHWLHPNLPEKDRRAWDYAVQFNLIHTAAMMAIFAVCKSVHPEGSAAKWLNRSFVLLFAGTTIFCGTVYAICLGVPGKQVGPLAPVGAITMMLGWVSVAIAGF
Protein: RNA uridylyltransferase (EC 2.7.7.52) (Q384M3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- REH2-associated factor 1
Sequence:
MRKFSAFRSGNTGVKRCITLPWKSSLPPKSDSQWEGLGKSVVRMALASDTGRSAFDECSTARQQLETLVQSTGYDASVFAFGGIVVMGLLEVGGDADFVGVADVEPGVAEAGEIVSRLSREMRRLGLKSSALPKARVPVIKVDRVSKSLPGTPLHHLSTCGIFQFTRQMNNNECTSFKSRMEENFGAVNTEWSNNQQFSTVEFSSSSALVAALTEVKRHEGVDIPLRLPVDPRNGPELYRLSFDFCFSSVGLRNSYLLSDALSKYVFSRHLLLLIKRWGRSSGVINSIDGLLASYALTVMCAHFLIKVGVIPKVSTLRSADEPQLLPPFPDYRPLHDGEDCDLAELGFLTAAFFEYYGAVFDYGKNVVCTTNINLLKKTMRWEKSPGTETGRPPFFEFAIKDPYGLDNIGRNLDSEATEYVRSAHSAALATLLQERGDPDFTVNIITKSPPRPVRRSRTLASRGIASTTYSSDQLEARHLLKKVAFHERRKSMERFGARAARHTEEQRVVSNVAKDVLGWIKCDNHQ
Protein: Serine/threonine-protein kinase ksp1 (EC 2.7.11.1) (Serine/threonine-protein kinase ppk20) (O14328)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MKLLQKKGYKVERPLNKGSYGTVVLAHRLFRTPRCKDLKYAIKCIKKPAYTFLQEVNILRQLSRSRHRNIIHFVESFEDNVYYYVVLEYCPLGDLYECILNNDFPNAKNQPEMIKNIFLQIIDGVAHLHSHGIYHRDLKPENFLLSLSEDGSELVVKISDFGLACRDKISYDFGTGSDRYMAPEQFEEVDGAGYSPRAADIWALGICLLNLIFARNPFTYPHEKDPIFADYMLDAMTLFDVFPTLSQDTYNVLRACLCVSPEKRSLAKTREAVLAVTKWTTDDEELESFVNEEEEFRASDFMPAEDNVRCTQSDREPLRTPSVLTPANTIQRGLLPSKLPALSDVDENISTSSSPRSPASLAPVNNSERSYDSGLGESLNNMHIGKSIATAVPVNTKRSPYSCSAPAIVFPNSIKGNKDHLKFGRSWCDMDEEDEEDIVSFGSNDDFGASDELSSKHIGLADDWNVLSQWNDNS
Protein: Male sterility protein (I7LW01)
Organism: Tetrahymena thermophila (strain SB210)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MGKVFQFYEGKTVLLTGITGFLGKVIFEKFLRTLPMVKRIYVLIRSKKGSPVEERFKKVIHDSEIFERLRQEKGDNFFNYLFSKVVPIEGDLLKEGLGLSKQDYQTITQEANIVINCAASVDFNAKLEEAININVRGSLRMMELSKQCLQLENFVHVSTCYVNSDKRGWIEEDIYNTEQNARQLMDDLMKMPPAELERQTKTILGNYPNTYVFTKSAVERIIKAERPPNMTITIVRPSIIGAAVSEPCVGWVEGVTAASAVFLLSGIGMLKYIHANRNAIGDVVPVDVVSDQIIVTGALCANLRDLSVFNASTSSRNPMLWEVSERNTVQYWRANPPEKRLGSCEAQLIKDERHLRFKQIMRRIPALAYLKLSNFVGSENMKKNANRYLKIIYKAESVSATFSHFASNEWIFDSRKIEKMIDQLDEQEKNAFYLDVSGINWDNYILMFNWGMHRYVLNEKVEPPVSDKNDILKINNQAKYPYFSDINWALSSGKPFKPRSYEEYKSLLFNSSAVQDAISLVIEQQTKKQGFSQGLVENVNKEAHAIIKEMISNYKMSTLRMMAWFLHKVFKQIYEKVVIDDVNLKALANHNVKKDGPLIMIPTHRSYIDFLLVSYIFFAYKMQCPHIAAAEDFLNVTVVHHILRACGAFFTKRNQKENPLYKAIFYEYVQRLLMDDCMLEFFVEGTRSRSGKMLHPKFGIMGIVADAVFDSKIPDAKIVPITLNYDKVLEGDTFPYELLGEEKVKESLPRLIKAIKTLSMNFGRIHVNICEPMSIKQYLATNYPTADLTNRVQRKSIIEDLSYKIEYKLTDALVCMPTGIVSAIMLQSRKGITEDKLINKVHWVSQRIVERGGILAFTPDVSGSMIATRSSMNLLEGILLKTKKNVFELEVTSDTEYKNVLMLSYYRNQIVHLFILEAIVCVALTAFGPNVAFKEGVSLERIWEESSFLIELFEREYVLPNVPKTLEQFSKTLLAKMIELKVLKVNESGKICIVDENQVSFYNSLIYPLVESYWSVLLNFYTLSQSKTKFMPLKKFLQQAQWFTENMHDERIIQHHESCSLDTIKNAIQKYKHFKLIRTYTDADKSGAEENILLLVNEEKLNELETHIQKFLKKGFSQSGSVSDLAKRTLLSEYPILARL
Protein: Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (UHR-1) (Q64121)
Organism: Rattus norvegicus (Rat)
Function: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prolactin-releasing peptide
- Pro-FMRFamide-related neuropeptide FF
- Orexigenic neuropeptide QRFP
Sequence:
MTSLPPGTTGDPDLFSGPSPAGSTPANQSAEASESNVSATVPRAAAVTPFQSLQLVHQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLKLSAYAVLGIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLRNRVVPGSVTQSQADWDRARRRRTFCLLVVVVVVFALCWLPLHIFNLLRDLDPRAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKMLLSWPRKIVPHGQNMTVSVVI
Protein: Bifunctional diguanylate cyclase/cyclic di-GMP phosphodiesterase MucR (DGC/PDE) (EC 2.7.7.65) (EC 3.1.4.52) (c-di-GMP-synthesizing enzyme) (Q9I310)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:19088322}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mannuronan synthase
Sequence:
MLISSYNQVLVAFSLIVAILASYTALDMAGRVTLAKGREALSWLIGGAFAMGFGIWSMHFVGMLAFSLPIPLGYDLGLTLLSLLLAVGSSAFALWLVCQAELPWQRLALGALLMGSGIAAMHYTGMAALLMMPGIVYDPLWLGLSILIAVIASGAALWIAFRLRHGSRRIVLVRAGAALVMGCAIVGMHYTGMAAAQFPLGSFCGAAGRGIDNGWLAVLVIVITLAVIAIALIVSVLDSRLEARTSVLATSLARANRELIQLALHDNLTKLPNRMLLDDRLEQAIQQAIRDDRRFAVLFMDLDGFKAVNDAYGHHLGDLLLIEVAERIRANVRAQDTIARLGGDEFVLLIEAREPADAATLAEKLVKRISQPYQISRHEVRISASIGIALYPGDGQTRHELMINADAAMYHAKDQGRNGYCFFESSMNANAQEQLQLLHDLRQALERRQLVLHYQPKVLAPNGPMIGVEALLRWEHPQHGLITPGQFLPLAEKTGLIVQIGEWVLDEACRQMRLWLDGGHADWNIAVNLSALQFAHAGLVDSVRNALLRHSLEPSHLILEVTESTAMRDADASLVILEQLSAMGVGISIDDFGTGYSSLLYLKRLPASELKIDRGFINELAHDSDDAAIVSAIVALGRTLNLKIVAEGVETEAQQEFLTRLGCNSLQGFLLGRPMPAEQLLASVA
Protein: Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser) synthetase) (O14018)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49591}.
Interaction partners:
- Probable glutamine--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- Tryptophan--tRNA ligase, cytoplasmic
- Probable proline--tRNA ligase, mitochondrial
- Putative leucine--tRNA ligase, cytoplasmic
- Tryptophan--tRNA ligase, mitochondrial
- Probable asparagine--tRNA ligase, cytoplasmic
- Putative proline--tRNA ligase C19C7.06
- Probable cysteine--tRNA ligase
- Putative leucine--tRNA ligase, mitochondrial
Sequence:
MLDINLFQVEKGGNPEIIRESQRKRGADVGVVDKVIEMYKEWVSLRFELDNTNKSINRVQKEIGLKMKAKEDASELLEEKNSLTERKKNLIEQETAKNKEMLNVVSSIGNIVHDSVPVSMDEDNNEIIRKWAPEGVTVEKKNCLSHHEVLTRLDGYDPERGVKVSGHRGYFLRQYGVFFNLALIQYGLDFLEKRGYIALQAPTMLNKDVMAKTAQLEQFDEELYKVIDGDEERYLIATSEQPISAYHSGEWFEKPSEQLPLKYAGYSTCYRREAGSHGRDAWGIFRVHAFEKIEQFVLTDPEKSWEAFTEMINHAEDFYKSLELPYRIVAIVSGALNNAAAKKYDLEAWFPFQGEYKELVSCSNCTDYQSRNLEIRCGVKKMGDREKKYVHCLNSTLCATERALCCILENYQTPDGVNVPKVLQPYMGGKTFLPFTKELPKNSTSKKGKN
Protein: A kinase (PRKA) anchor protein 12b (A-kinase anchor protein 12b isoform 1) (A0A0R4IC31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
Sequence:
MGATPSVQRDAKSPEDAPEDVSAPLSDAHDGETADGKPLQKNGQISISSLNGKTDDQTEYNGHTEENPPAEVGQTDTISPKEDSPETIEVHQEEVAPQMNGEKGDDSANADEITTAEEKVVEEKQEEANEVGFKKIFRFVGFKFTLKKDKNEKTEPVQLLTVKEAESGADAATEEKKEEPAAEEDRSVEEKSPETTENEAKAEEVTEKAEEPAEQTVVDAPSETEKVSDIETEKPAEETGTISEKEPEPEVPAESPTSPPSQETQSPFKRFFTQGIFSNLRKKASFKKPKDEEHVKEKPVEEDIKETEETAEGVPEATEEAKVDAENEPAEGEQIEKPSETVETKAETTTETTAETTNEVTPTEKEEQQDLKVEAEATSEVETVTHTEPAQAPAVETTQPTDDAKTSDKPDISEEAPTEPEILSSQEKSKAHGSPLKKLFTGAGLKKLSSKKHKNKKDAESKQTESSEQTAETVQSTESTEPQKPDSGASSPEESGEHVVGEVAQAEVAQAVEPDGDAVTSDGEKKKEGILPWSSFKKLVTPKKRVKRPSESEDEAPGDKPKSSTLSSTESAISDEKADEPKPSEEVPSKEELKEEAKEESQAESKTEPKAEKSESVAEEPKRKMDTSVSWEALICVGSSKKRARKTSDSDDEEAKIEEEVQPSEEEPIKTAESPLVSSGEADHENLASSPEPEGELVSTWESFKRLVTHRKKAKAEDKSDEASGPEQTTSDSETPKEESSFSLRKLIPRRKKKSDGKQEQVSSDVGSAEDDSDTPAVVPLSEYDSEPSAEAAVKAEEVKQESATVTQAKASAEDRSPSWISTTVENVEDETEGNQLSDIPEEGDTAATPKSTDNTIAEDIVELTSEAVTALEQVEETEMVSAVSRVTASPDTSGETTPVPGDGVERKTDVVIQEAVETISVTTNAMAVTMTEEQETVVAITTDALLVESATKEQKTVLVAHEKNEAVAVCTGLDTSEIRAVEEESLNQKPSVESATVVSQPLVTEVAVEEKTQEPERVTVTEDEVHEAQTSGVQAELKDQPIENAIEEKAQFEEIKDTPIAETVADIHEVAAVKVAVISAVQQEPEILEEPVMAEKSPEIESAGPVEATVEEAICAQTAEVTEVAVAEGEKVQELDDVKETVATVEVASVENVSTAVTEEVMATLPEVPASQIAGSTEDPIPVVAATEEFAVIKETICVSSISETTESHSADIAKETLMENVPVVLSTGDHKMQVAVNEVEVVSAQGVVEGNIEAASTKLSVALEEVTENVKEETEIIQATQVTEAEIIEKQSSVIVQEIIQNVVENFAEAHGEQNVSEKTTEESCITSAEVKVNEISVETTEEGSSTDKLAASDNVCKDVEETRIVTEKPPKIVNEAIQIAETVPVSITDEIQAQNEEVASVSVADVHQETEVTKSEVELKQAEEKSQSTKNEEGISEVESDLKEVQAEIQQEIKAVPEEKTAETSVTVASQDQVVAEQCQVTLTAVQIETAQEFNVGVVNVINADDVPETNMKEDCSEGQESTEDRPQNDLEEPQTKVSTNQEESRGPDCQKTDAKNVPAKLEAASEMTSNATAAEEVGNEIEPVSTEVVTVS
Protein: DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) (Q9Y6K1)
Organism: Homo sapiens (Human)
Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:12145218}. Chromosome {ECO:0000269|PubMed:12138111}. Cytoplasm {ECO:0000269|PubMed:12145218}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250|UniProtKB:O88508}.
Interaction partners:
- Histone H3.3
- Histone-lysine N-methyltransferase EZH2
- Histone H3.1
- Histone H3.2
- DNA
- DNA
- Histone H3.1t
- Histone H3-7
- Histone H3.3C
- DNA
Sequence:
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Protein: Proline rich transmembrane protein 2 (A0A1B0GTP1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASSSEISEMKGVEESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSPRVPEQPAAGGRGRGPASGPGSQALKHRGAGGGSPHHHRLLRHQLRRV
Protein: Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) (O15054)
Organism: Homo sapiens (Human)
Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
Subcellular location: Nucleus {ECO:0000305|PubMed:17825402}.
Interaction partners:
- Histone H3.2
- Histone H3-7
- Histone H3.3
- Histone H3.1
- Retinoblastoma-binding protein 5
- WD repeat-containing protein 5
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Histone-lysine N-methyltransferase EZH2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Histone H3.3C
Sequence:
MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR
Protein: Acidic leucine-rich nuclear phosphoprotein 32 family member A (Q9V895)
Organism: Drosophila melanogaster (Fruit fly)
Function: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
Interaction partners:
Sequence:
MEKRIELERRARKVNQITELNLDNCRSTSIVGLTDEYTALESLSLINVGLTTLKGFPKLPNLKKLELSDNRISSGLNYLTTSPKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDLFNNDATQVDNYREKIFKMLPSLNFLDGFDCNDEEVQSDGDDDDEVNGNDSDEVGVSDEDDDSDDSDEEANGEVSLSEVYNDDLEEDNSDWEGEDEAGEEDEEEDSDIDDADGDANESAASVNAKDKDGEKEADESQVRGKKRKHDG