wanglab/gogpt-training-data huggingface dataset:
Protein: Paraspeckle component 1 (Paraspeckle protein 1) (mPSP1) (Q8R326)
Organism: Mus musculus (Mouse)
Function: Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q8WXF1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8WXF1}. Nucleus matrix {ECO:0000269|PubMed:15140795, ECO:0000269|PubMed:16641145}. Cytoplasm {ECO:0000269|PubMed:15140795}. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. {ECO:0000250|UniProtKB:Q8WXF1}.
Interaction partners:
- Non-POU domain-containing octamer-binding protein
- Splicing factor, proline- and glutamine-rich
- RNA-binding protein 14
- RNA-binding protein FUS
- Matrin-3
- TAR DNA-binding protein 43
- Cleavage and polyadenylation specificity factor subunit 6
- Histone deacetylase 1
Sequence:
MMLRGNLKQVRIEKNPARLRALESAAGESEPVAAAAMALTLAGEQAPPPAPSEEHPDEELGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMIPDNGAVHNDRFPQGPPSQMGSPMGNRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY
Protein: Adaptor protein complex 1, mu subunit (Clathrin-associated adaptor complex AP-1 medium chain) (Clathrin-associated protein) (LD31377p) (O62531)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- AP complex subunit beta
- AP complex subunit sigma
- AP-1 complex subunit gamma
- LD33778p
- LD20590p
- AP-2 complex subunit alpha
- AP complex subunit sigma
- Adaptor protein complex AP-3 small chain sigma3
- Clathrin heavy chain
- Clathrin light chain
Sequence:
MSSSAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGLITPILQTAETTFAYIKTNNLYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLDFGYPQTTDSKILQEYITQEGHKLELQPRIPVAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIVIPVPADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEYLMRAHFGLPSVESEDNTEGKPPIQVRFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN
Protein: GPI-anchor transamidase (Q59PU4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- GPI-anchor transamidase subunit
- GPI-anchor transamidase subunit
- GPI-anchor transamidase subunit
- Uncharacterized protein
- GPI ethanolamine phosphate transferase 3
- Glycosylphosphatidylinositol anchor biosynthesis protein 11
- GPI inositol-deacylase
- GPI mannosyltransferase 4
- GPI mannosyltransferase 2
- GPI mannosyltransferase 1
Sequence:
MNRLLSFILPIFLIFSTVLSSDSPNDSVNINNSDPSRHSNNWAVLVSTSRFWFNYRHMANTLSLYRTVKRLGIPDSQIILMLSDDIACNPRNAFPGSVFNNMDEAIDLYGESIEVDYRGYEVTVENFMRLLTDKWDSDQPRSKRLLSDENSNIFIYLTGHGGNEFLKFQDAEEISAHDLADAFSQMYDQKRYNEIFFMIDTCQANTMYEKIHSPNILAVGSSEIEESSYSHHSDMDIGVAVIDRFTYYTLDFLEKIDRDSKETMDKLFAEYTFENVHSHPGIRTDLFKRNVSEVLLTDFFGNVQNVVVDDVNMELLENEKVTESNEDNNQTKNIIKERGPTQFSFECDENSKSLIKVPQLHARIFGVVTVGVIVALWFISSKF
Protein: Peptidoglycan recognition protein 1 (Cytokine tag7) (Peptidoglycan recognition protein short) (PGRP-S) (O88593)
Organism: Mus musculus (Mouse)
Function: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9660837}. Secreted {ECO:0000269|PubMed:14585845, ECO:0000269|PubMed:9660837}. Note=Exists in both soluble and membrane-associated forms.
Interaction partners:
- Heat shock 70 kDa protein 1B
- Triggering receptor expressed on myeloid cells 1
- Lactotransferrin
- Cathelicidin antimicrobial peptide
Sequence:
MLFACALLALLGLATSCSFIVPRSEWRALPSECSSRLGHPVRYVVISHTAGSFCNSPDSCEQQARNVQHYHKNELGWCDVAYNFLIGEDGHVYEGRGWNIKGDHTGPIWNPMSIGITFMGNFMDRVPAKRALRAALNLLECGVSRGFLRSNYEVKGHRDVQSTLSPGDQLYQVIQSWEHYRE
Protein: Secretory immunoglobulin A-binding protein EsiB (A0A0H2VDN9)
Organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Function: Upon host (human neutrophil) infection interferes with productive FCAR signaling, inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils, decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils, all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils, but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins, including phospholipase C-gamma and MAP kinases, all actions that may be advantageous to the pathogen.
Subcellular location: Cell surface {ECO:0000269|PubMed:23882011}. Note=Accumulates at 1 cell pole in the bladder of mice infected with this strain, in overexpressing bacteria the protein is found all over the cell surface but not in the secreted fraction (PubMed:23882011). Human blood sera from clinical patients with urinary tract infections reacts with antibodies to this protein (PubMed:23882011). {ECO:0000269|PubMed:23882011}.
Interaction partners:
Sequence:
MKKSLLAVMLTGLFALVSLPALGNVNLEQLKQKAESGEAKAQLELGYRYFQGNETTKDLTQAMDWFRRAAEQGYTPAEYVLGLRYMNGEGVPQDYAQAVIWYKKAALKGLPQAQQNLGVMYHEGNGVKVDKAESVKWFRLAAEQGRDSGQQSMGDAYFEGDGVTRDYVMAREWYSKAAEQGNVWSCNQLGYMYSRGLGVERNDAISAQWYRKSATSGDELGQLHLADMYYFGIGVTQDYTQSRVLFSQSAEQGNSIAQFRLGYILEQGLAGAKEPLKALEWYRKSAEQGNSDGQYYLAHLYDKGAEGVAKNREQAISWYTKSAEQGDATAQANLGAIYFRLGSEEEHKKAVEWFRKAAAKGEKAAQFNLGNALLQGKGVKKDEQQAAIWMRKAAEQGLSAAQVQLGEIYYYGLGVERDYVQAWAWFDTASTNDMNLFGTENRNITEKKLTAKQLQQAELLSQQYIEKYAPEAWARMQKLKAQSAVKTGNK
Protein: Putative tyrosine-protein phosphatase OCA6 (EC 3.1.3.48) (Oxidant-induced cell-cycle arrest protein 6) (Q12454)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for replication of Brome mosaic virus (BMV).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Tyrosine-protein phosphatase-like protein OCA2
- Protein OCA4
- RNA polymerase II subunit B1 CTD phosphatase RTR2
- GTP-binding protein YPT1
- Oxidant-induced cell-cycle arrest protein 5
Sequence:
MTLVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMVKFCEENNIKTIHIKCQSERKADKTKPKIKRKKKTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNSEIEVDDLDIKDKVPWITVRYIARTATESKDELRVDDANASEKVARVSSVSNSLPKLKFHSM
Protein: Substrate of serine protease (Capsid) (O39491)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MSAAHQAGAASAHPLPAGDYVYVPTAQYNQLVVSQARGAAMTAAPPPAPYFLPAAAAAAAAPPPMPGWYGAAGAAPWHPGYGFPPPGLESQIMALAGAIADGRRVQAHGADGSGYDGPLDRRPLAKRRRYNWDHPRGRSGGGDDDEAYYPGEGAPAELPPHHHSPPPPHPPPSHALSKLASAVSSLQQEVSQLRAGYPYGPAFAAAQHPPAAHLPCLPQQYTAPPRVGAGPAQVPTLAPAQAPAQALSVPAVAAAPATVAAAAAVGPPEEPGVAATVDASAMASLPPAQPPQACDPAEIFVAQMMRQR
Protein: Sepiapterin reductase (SPR) (EC 1.1.1.153) (P35270)
Organism: Homo sapiens (Human)
Function: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Subcellular location: Cytoplasm.
Interaction partners:
- Dihydropteridine reductase
- Dihydrofolate reductase 2, mitochondrial
- 6-pyruvoyl tetrahydrobiopterin synthase
- Dihydrofolate reductase
- Phenylalanine-4-hydroxylase
- Carbonyl reductase 1])
- Aldo-keto reductase family 1 member B1
- Tyrosine 3-monooxygenase
- Tryptophan 5-hydroxylase 1
- Tryptophan 5-hydroxylase 2
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
Protein: Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z) (Q9H832)
Organism: Homo sapiens (Human)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17160626}. Nucleus {ECO:0000269|PubMed:17160626}.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme 6
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin D
- Polyubiquitin-B
- Ubiquitin-conjugating enzyme E2 Q1
- Ribosome biogenesis protein WDR12
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like modifier-activating enzyme 7
- NEDD8-activating enzyme E1 catalytic subunit
Sequence:
MAESPTEEAATAGAGAAGPGASSVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV
Protein: LD21875p (Q8SX79)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSHVAHSHPESDNPLAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPILYENFDDIYGTSPECDFLTGHQVQKAESSDSDKVMITCACCSFASSPLISRYPTSYLLQTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRNVQVTSLCISSSYGL
Protein: Nucleolar protein 4 (Nucleolar-localized protein) (O94818)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:9813152, ECO:0000269|PubMed:9853615}.
Interaction partners:
Sequence:
MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSKGFQLGQPDEVRGGGGGAKQVLYVPVKTTDGVGVDEKLSLRRVAVVEDFFDIIYSMHVETGPNGEQIRKHAGQKRTYKAISESYAFLPREAVTRFLMSCSECQKRMHLNPDGTDHKDNGKPPTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLSSNLEERMQSPQNLHGQQDDDSAAESFNGNETLGHSSIASGGTHSREMGDSNSDGKTGLEQDEQPLNLSDSPLSAQLTSEYRIDDHNSNGKNKYKNLLISDLKMEREARENGSKSPAHSYSSYDSGKNESVDRGAEDLSLNRGDEDEDDHEDHDDSEKVNETDGVEAERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKRIRTYLKSCRRMKRSGFEMSRPIPSHLTSAVAESILASACESESRNAAKRMRLERQQDESAPADKQCKPEATQATYSTSAVPGSQDVLYINGNGTYSYHSYRGLGGGLLNLNDASSSGPTDLSMKRQLATSSGSSSSSNSRPQLSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN
Protein: Putative basic amino acid antiporter YfcC (P39263)
Organism: Escherichia coli (strain K12)
Function: Metabolomic profiling of different yfcC over-expression and deletion strains suggests that it may affect the glyoxylate shunt.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Epimerase family protein YfcH
- Uncharacterized protein YeiS
Sequence:
MSAITESKPTRRWAMPDTLVIIFFVAILTSLATWVVPVGMFDSQEVQYQVDGQTKTRKVVDPHSFRILTNEAGEPEYHRVQLFTTGDERPGLMNFPFEGLTSGSKYGTAVGIIMFMLVIGGAFGIVMRTGTIDNGILALIRHTRGNEILFIPALFILFSLGGAVFGMGEEAVAFAIIIAPLMVRLGYDSITTVLVTYIATQIGFASSWMNPFCVVVAQGIAGVPVLSGSGLRIVVWVIATLIGLIFTMVYASRVKKNPLLSRVHESDRFFREKQADVEQRPFTFGDWLVLIVLTAVMVWVIWGVIVNAWFIPEIASQFFTMGLVIGIIGVVFRLNGMTVNTMASSFTEGARMMIAPALLVGFAKGILLLVGNGEAGDASVLNTILNSIANAISGLDNAVAAWFMLLFQAVFNFFVTSGSGQAALTMPLLAPLGDLVGVNRQVTVLAFQFGDGFSHIIYPTSASLMATLGVCRVDFRNWLKVGATLLGLLFIMSSVVVIGAQLMGYH
Protein: Gastrulation brain homeobox 1 (Homeobox protein GBX-1) (Transcription factor Gbx1) (Q90ZB2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- LIM domain only 4, like
Sequence:
MQRPSGTGTAFSIDSLIGTPQPRPGHLLYTGYPMFMPYRPLMIPQALSHSSLPSGIPPLAPLASFAGRLTNTFCAGLGQGMPSMVALTTTLPSFSDPPDSFYPPQEMPGPRLGADGTGMNRQESPHDELKGSELLNFTETFQAVAGETKLYSSDDEKLDLKAAEAACSDREDSSADSENESFSDGNTCASASQKGKLKGGSQDALPPGGSAGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVNNRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQIEPGSRP
Protein: Hydrogenase-4 component F (EC 1.-.-.-) (P77437)
Organism: Escherichia coli (strain K12)
Function: Possible component of hydrogenase 4.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Hydrogenase-4 component E
- Hydrogenase-4 component G
- Hydrogenase-4 component I
- Hydrogenase-4 component D
- Hydrogenase-4 component B
- Hydrogenase-4 component C
- Formate hydrogenlyase subunit 5
- Formate hydrogenlyase subunit 4
- Hydrogenase-4 component H
- Formate hydrogenlyase subunit 7
Sequence:
MSYSVMFALLLLTPLLFSLLCFACRKRRLSATRTVTVLHSLGITLLLILALWVVQTAADAGEIFAAGLWLHIDGLGGLFLAILGVIGFLTGIYSIGYMRHEVAHGELSPVTLCDYYGFFHLFLFTMLLVVTSNNLIVMWAAIEATTLSSAFLVGIYGQRSSLEAAWKYIIICTVGVAFGLFGTVLVYANAASVMPQAEMAIFWSEVLKQSSLLDPTLMLLAFVFLLIGFGTKTGLFPMHAWLPDAHSEAPSPVSALLSAVLLNCALLVLIRYYIIICQAIGSDFPNRLLLIFGMLSVAVAAFFILVQRDIKRLLAYSSVENMGLVAVELGIGGPLGIFAALLHILNHSLAKTLLFCGSGNVLLKYGTRDLNVVCGMLKIMPFTAVLFGGGALALAGMPPFNIFLSEFMTITAGLARNHLLIIVLLLLLLTLVLAGLVRMAARVLMAKPPQAVNRGDLGWLTTSPMVILLVMMLAMGTHIPQPVIRILAGASTIVLSGTHDLPAQRSTWHDFLPSGTASVSEKHSER
Protein: DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) (P41138)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor E2-alpha
Sequence:
MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH
Protein: Cathepsin B, isoform A (Cathepsin B, isoform C (EC 3.4.-.-, EC 3.4.22.-)) (GH06546p) (Q9VY87)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cathepsin D
- Peptidase A1 domain-containing protein
- LP12231p
- RE02351p
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- MIP16848p
- Uncharacterized protein, isoform A
Sequence:
MNLLLLVATAASVAALTSGEPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSISAGLPKL
Protein: Deterin (GEO07887p1) (RE55472p) (Q9VEM2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Borealin
- Inner centromere protein, isoform A
- Aurora kinase B
- Australin, isoform A
- Caspase drICE
- Aurora kinase
- AT03047p
- Ubiquitin-conjugating enzyme E2 C
- Death-associated inhibitor of apoptosis 2
- Mitotic spindle assembly checkpoint protein MAD2A
Sequence:
MESPVVNEVAASLGGEKLEVFRKLNLLEQHRVESYKSWPFPETASCSISKMAEAGFYWTGTKRENDTATCFVCGKTLDGWEPEDDPWKEHVKHAPQCEFAKLSCPERNLTVSQFLEILGTVVKGSIEKTCKAFKSSFVRENEKRLDEFTRNQK
Protein: Brassinosteroid-related acyltransferase 1 (BR-related acyltransferase 1) (EC 2.3.1.-) (Protein DWARF AND ROUND LEAF 1) (Protein PIZZA) (Q9SZ58)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Brassinosteroids (BR) acyltransferase with acyl-CoA ligase activity toward brassinolide (BL), castasterone (CS), typhasterol (TY), 6-deoxotyphasterol (6-deoxoTY), and 6-deoxocastasterone (6-deoxoCS) and thus converts them to corresponding lauroyl esters. Regulates BR homeostasis and promotes BR-mediated cell growth regulation. Involved in vascular bundle development.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:23020607}. Nucleus {ECO:0000269|PubMed:23020607}. Note=Localizes in the endoplasmic reticulum in young tissues and the phloem of vascular bundles. {ECO:0000269|PubMed:23020607}.
Interaction partners:
- Protein kinase PINOID 2
- GPI mannosyltransferase 1
- Cytosolic sulfotransferase 10
- Expressed protein
- Filaggrin-like protein
- Probable WRKY transcription factor 45
- GDSL esterase/lipase At5g45910
- Probable disease resistance protein RPP1
- UDP-glycosyltransferase 73C6
- Probable WRKY transcription factor 66
Sequence:
MPMLMATRIDIIQKLNVYPRFQNHDKKKLITLSNLDRQCPLLMYSVFFYKNTTTRDFDSVFSNLKLGLEETMSVWYPAAGRLGLDGGGCKLNIRCNDGGAVMVEAVATGVKLSELGDLTQYNEFYENLVYKPSLDGDFSVMPLVVAQVTRFACGGYSIGIGTSHSLFDGISAYEFIHAWASNSHIHNKSNSKITNKKEDVVIKPVHDRRNLLVNRDAVRETNAAAICHLYQLIKQAMMTYQEQNRNLELPDSGFVIKTFELNGDAIESMKKKSLEGFMCSSFEFLAAHLWKARTRALGLRRDAMVCLQFAVDIRKRTETPLPEGFSGNAYVLASVASTARELLEELTLESIVNKIREAKKSIDQGYINSYMEALGGSNDGNLPPLKELTLISDWTKMPFHNVGFGNGGEPADYMAPLCPPVPQVAYFMKNPKDAKGVLVRIGLDPRDVNGFSNHFLDC
Protein: RE24187p (Q5U183)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSRRLNVFQGDTFEANYTKYESEPIFWSSNDELQLTDTLSGILPIAPTDESLLNHNREEDLQNRKNLELSNHDANELNAQVYRSIADSGGEIAYEQQRQISAIVEYDKEDIKIDGLTEEEDIQSQSTFRTRTDSSSIGDYESHSSDYDDEFDIVNEEKSPRLQVVHNNIGNLQSSCERKGRTLSTNTIISEVDALGLSIDVNNFDLADFITKDDFAENLNACRKKESLQAQAQIKSNTLADVPILLNPPVATIVAKPGVPSSKPGDSDYDSGSIIDVETVDVLDMNMANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKPEQLGNHQLAVPASNKPKHKNICLVPNKKQCDFLKRKVGSPSLSKLTKATTKKATESMSNKQPSVKNTQCTGLGLGGKNLSLLKQERDAALSVCAAKPIAPPTLSTTTPTLTPPAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQAKIEVAAKRIAPTPVSKPTPSPKKAEIVNIVNSLKCPRTEQSSLPMDPITMAKNKVLRMLEMKRAQQLKIIDSRVSAKVPRVTKLPPLKDIVKDTYCMETEDPGTEIAPLSNKLHPDYEEIIIVSASCNTDITIPPNQLSKASPRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVMSSADKNCQHGEDMVIMHLPKDRVRKTLVSIATQTDLQPEFPLLTLPPKRQSRERTRRNYRRRRTQGSGSNMSTSSSDFSSDCSSLVSHRSRSQYDSIDQLRNLDVAATCGGSIGNGGYSSRSTQRHRSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGSTSSSCSGSEKSDRERSRSPHRKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTKEILRRKFLPYGSIKQITIHYKENGMKYGFVTYERAQDAFTAIDTSHRDSQISMYDISFGGRRAFCRSSYADLDNAGINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAKLNAGKSPVGSSTLEAPSASGTVLQGHSQM
Protein: Rab23 (Small G-protein) (O76225)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MLKRGGLNGVKVIVIGDENVGKSSLLRRFVTGTFSNQYNKTVGVEYMEKSVCLRQRSTTVNSFLWDTAGQETVSSVKDIYYLDAAVAILVFSTDSSESFARIEMWKRCVERVCGSIPMVLCQTKFDLARQAAVVAEEVEKLAVKLQLPLFRVSTKDGFNVTQLFEYVAAMCVSEAPGGECGRTGKLKSEADGNGSTGAGNAGKSSKSGGAGKKSSKKSKKKKCSVM
Protein: Thiol:disulfide interchange protein DsbE (Cytochrome c biogenesis protein CcmG) (P0AA86)
Organism: Escherichia coli (strain K12)
Function: Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD.
Subcellular location: Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Interaction partners:
- Cytochrome c-type biogenesis protein CcmF
- Thiol:disulfide interchange protein DsbD
- Cytochrome c-type biogenesis protein CcmE
- Cytochrome c-type biogenesis protein CcmH
- Heme exporter protein C
- Cytochrome c biogenesis ATP-binding export protein CcmA
- Heme exporter protein B
- Heme exporter protein D
- Thiol:disulfide interchange protein DsbA
- Alkyl hydroperoxide reductase C
Sequence:
MKRKVLLIPLIIFLAIAAALLWQLARNAEGDDPTNLESALIGKPVPKFRLESLDNPGQFYQADVLTQGKPVLLNVWATWCPTCRAEHQYLNQLSAQGIRVVGMNYKDDRQKAISWLKELGNPYALSLFDGDGMLGLDLGVYGAPETFLIDGNGIIRYRHAGDLNPRVWEEEIKPLWEKYSKEAAQ
Protein: Protein MTSS 1 (Metastasis suppressor protein 1) (Missing in metastasis protein) (Q8R1S4)
Organism: Mus musculus (Mouse)
Function: Inhibits the nucleation of actin filaments in vitro.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
Sequence:
MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKNKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAANQLSNGFSHCSLSSESHAGPVGAGPFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDSNGGGPTTTGGPPAGAEEAQRPRSMTVSAATRPGEEMAACEELTLALSRGLQLDVQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEAEQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPSPPDGPEERGEHSPESPSAGEGPQGVSNIPSSLWSGQAPVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATVSPGPIPESDPADLSPRESPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS
Protein: Ras-related protein Rab (A1Z7S2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU367128}; Lipid-anchor {ECO:0000256|RuleBase:RU367128}.
Interaction partners:
Sequence:
MQQQQQRGHRLNARPLAELANTEPQPSGQQSLDPSTSPPAAEDGVSSAESAQTIANPPPVVRFEVGSAVRSPLSAYEAALAAAASQQPNSNEELSDSSIRRLSFAQQQLILGDHDSIEGRRETLHYQSVASEYSNQDSGSEDDSEEQADTTEPENAKPMPAFGDLTMDQEMEPAIMTSTSDKREHLYKILVIGELGTGKTSFIKRYVHQFFSQNYRATIGVDFALKVLQWDANTIVRLQLWDIAGQERFGNMTRVYYKEAVGAFIVFDVTRSGTFDCVSKWKEDLDSKVQLPDGSPIPCILLANKCDQEKQGIITQPEKMDEYVRENGFAGWFETSAKENINIDEAARALVNKILINDKLISADLADGDKFNLSAADATGSDAKNKCSC
Protein: Transcription factor bHLH74 (Basic helix-loop-helix protein 74) (AtbHLH74) (bHLH 74) (Protein ACTIVATOR FOR CELL ELONGATION 2) (Transcription factor EN 90) (bHLH transcription factor bHLH074) (Q6NKN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- ZCF37
- Cryptochrome-2
- At2g25250
Sequence:
MGGESNEGGEMGFKHGDDESGGISRVGITSMPLYAKADPFFSSADWDPVVNAAAAGFSSSHYHPSMAMDNPGMSCFSHYQPGSVSGFAADMPASLLPFGDCGGGQIGHFLGSDKKGERLIRAGESSHEDHHQVSDDAVLGASPVGKRRLPEAESQWNKKAVEEFQEDPQRGNDQSQKKHKNDQSKETVNKESSQSEEAPKENYIHMRARRGQATNSHSLAERVRREKISERMRLLQELVPGCNKITGKAVMLDEIINYVQSLQQQVEFLSMKLATVNPEINIDIDRILAKDLLQSRDRNTPTLGLNPFAGFQGNIPNLSATTNPQYNPLPQTTLESELQNLYQMGFVSNPSTMSSFSPNGRLKPEL