wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa) (Q02930)
Organism: Homo sapiens (Human)
Function: Binds to the cAMP response element and activates transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-2
- Transcription factor Jun
- Mitogen-activated protein kinase 1
- Cyclic AMP-responsive element-binding protein 1
- Cyclic AMP-responsive element-binding protein 3-like protein 4
- Mitogen-activated protein kinase 3
- Cyclic AMP-responsive element-binding protein 3
- CREB-binding protein
- Histone acetyltransferase p300
- Cyclic AMP-responsive element-binding protein 3-like protein 2
Sequence:
MIYEESKMNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTPTPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL
Protein: Serine-type endopeptidase inhibitor (Q9C7G9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Expressed protein)
- Ethylene-responsive transcription factor RAP2-13
- Cystine lyase CORI3
Sequence:
MVTYKIWVMSFIIAGAILGGIIPGVTTTKTAIACPLYCLQVEYMTCPSSGADKLPPRCNCCLAPKNCTLHLSDSTTIHCSK
Protein: 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) (Citrate synthase) (CS) (EC 2.3.3.16) (H8F0D7)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA.
Interaction partners:
Sequence:
MTGPLAAARSVAATKSMTAPTVDERPDIKKGLAGVVVDTTAISKVVPQTNSLTYRGYPVQDLAARCSFEQVAFLLWRGELPTDAELALFSQRERASRRVDRSMLSLLAKLPDNCHPMDVVRTAISYLGAEDPDEDDAAANRAKAMRMMAVLPTIVAIDMRRRRGLPPIAPHSGLGYAQNFLHMCFGEVPETAVVSAFEQSMILYAEHGFNASTFAARVVTSTQSDIYSAVTGAIGALKGRLHGGANEAVMHDMIEIGDPANAREWLRAKLARKEKIMGFGHRVYRHGDSRVPTMKRALERVGTVRDGQRWLDIYQVLAAEMASATGILPNLDFPTGPAYYLMGFDIASFTPIFVMSRITGWTAHIMEQATANALIRPLSAYCGHEQRVLPGTF
Protein: Transcription factor Dp-1 (DRTF1-polypeptide 1) (E2F dimerization partner 1) (Q08639)
Organism: Mus musculus (Mouse)
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:25940086}. Cytoplasm {ECO:0000269|PubMed:25940086}. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000305|PubMed:25940086}.
Interaction partners:
- Transcription factor E2F1
- Transcription factor E2F6
- Transcription factor E2F4
- Retinoblastoma-like protein 2
- Retinoblastoma-associated protein
- Transcription factor E2F5
- Transcription factor E2F3
- Retinoblastoma-like protein 1
- Transcription factor E2F2
- Mothers against decapentaplegic homolog 3
Sequence:
MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGKQLLPKTFGQSNVNITQQVVIGTPQRPAASNTIVVGSPHTPNTHFVSQNQTSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGNCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGEDDDDDDDFNENDEED
Protein: Nucleoporin NUP60 (Nuclear pore protein NUP60) (P39705)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Nuclear basket.
Interaction partners:
- Nucleoporin NUP2
- Protein MLP2
- Nucleoporin NUP1
- Protein MLP1
- Nucleoporin NUP100/NSP100
- Importin subunit beta-1
- Nucleoporin NUP116/NSP116
- Nucleoporin NUP57
- Nucleoporin NUP159
- Nucleoporin NUP49/NSP49
Sequence:
MHRKSLRRASATVPSAPYRKQIISNAHNKPSLFSKIKTFFTQKDSARVSPRNNVANKQPRNESFNRRISSMPGGYFHSEISPDSTVNRSVVVSAVGEARNDIENKEEEYDETHETNISNAKLANFFSKKGNEPLSEIEIEGVMSLLQKSSKSMITSEGEQKSAEGNNIDQSLILKESGSTPISISNAPTFNPKYDTSNASMNTTLGSIGSRKYSFNYSSLPSPYKTTVYRYSAAKKIPDTYTANTSAQSIASAKSVRSGVSKSAPSKKISNTAAALVSLLDENDSKKNNAASELANPYSSYVSQIRKHKRVSPNAAPRQEISEEETTVKPLFQNVPEQGEEPMKQLNATKISPSAPSKDSFTKYKPARSSSLRSNVVVAETSPEKKDGGDKPPSSAFNFSFNTSRNVEPTENAYKSENAPSASSKEFNFTNLQAKPLVGKPKTELTKGDSTPVQPDLSVTPQKSSSKGFVFNSVQKKSRSNLSQENDNEGKHISASIDNDFSEEKAEEFDFNVPVVSKQLGNGLVDENKVEAFKSLYTF
Protein: Protein NRT1/ PTR FAMILY 4.6 (AtNPF4.6) (Nitrate transporter 1.2) (Nitrate transporter NTL1) (Protein ABA-IMPORTING TRANSPORTER 1) (Q8H157)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Low-affinity proton-dependent nitrate transporter. Involved in constitutive nitrate uptake. Not involved in histidine or dipeptides transport. Involved in (+)-abscisic acid (ABA) transport, but not in gibberellin, indole-3-acetic acid or jasmonic acid import. Mediates cellular ABA uptake. Nitrate does not compete with abscisic acid as a substrate of NPF4.6.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22645333}; Multi-pass membrane protein {ECO:0000269|PubMed:22645333}.
Interaction partners:
- ABC transporter G family member 25
- Protein DETOXIFICATION 50
- ABC transporter G family member 40
- High-affinity nitrate transporter 2.2
- High-affinity nitrate transporter 2.1
- High affinity nitrate transporter 2.4
- High affinity nitrate transporter 2.7
- High affinity nitrate transporter 2.5
- ABC transporter G family member 22
- ABC transporter G family member 30
Sequence:
MEVEEEVSRWEGYADWRNRAAVKGRHGGMLAASFVLVVEILENLAYLANASNLVLYLREYMHMSPSKSANDVTNFMGTAFLLALLGGFLSDAFFSTFQIFLISASIEFLGLIILTIQARTPSLMPPSCDSPTCEEVSGSKAAMLFVGLYLVALGVGGIKGSLASHGAEQFDESTPKGRKQRSTFFNYFVFCLACGALVAVTFVVWLEDNKGWEWGFGVSTIAIFVSILIFLSGSRFYRNKIPCGSPLTTILKVLLAASVKCCSSGSSSNAVASMSVSPSNHCVSKGKKEVESQGELEKPRQEEALPPRAQLTNSLKVLNGAADEKPVHRLLECTVQQVEDVKIVLKMLPIFACTIMLNCCLAQLSTFSVQQAASMNTKIGSLKIPPASLPIFPVVFIMILAPIYDHLIIPFARKATKTETGVTHLQRIGVGLVLSILAMAVAALVEIKRKGVAKDSGLLDSKETLPVTFLWIALQYLFLGSADLFTLAGLLEYFFTEAPSSMRSLATSLSWASLAMGYYLSSVIVSIVNSITGSSGNTPWLRGKSINRYKLDYFYWLMCVLSAANFLHYLFWAMRYKYRSTGSRS
Protein: unspecific monooxygenase (EC 1.14.14.1) (Q8QFT4)
Organism: Gallus gallus (Chicken)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}.
Interaction partners:
Sequence:
MLLLGAASVVLLVCVACLLSIVQWRKRTGKGKMPEGPTPLPIVGNILEVKPKNLAKTLEKLAEKYGPVFSVQLGSTPVVVLSGYEAVKEALIDRADEFAARGHMPIGDRANKGLGIIFSNNEGWLHVRRFALSTLRNFGMGKRSIEERIQEEAEHLLEEITKTKRLPFDPTFKLSCAVSNVICSIVFGKRYDYKDKKFLSLMNNMNNTFEMMNSRWGQLYQMFSYVLDYLPGPHNNIFKEIDAVKAFVAEEVKLHQASLDPSAPQDFIDCFLSKMQEEKDNPKSHFHMTNLITSTFDLFIAGTETTSTTTRYGLLLLLKYPKIQEKVQEEIDRVVGRSRRPCVADRTQMPYTDAVVHEIQRFITLIPTSLPHAVTKDIHFRDYIIPKGTTVMPLLSTALYDSKEFPNPTEFNPGHFLNQNGTFRKSDFFIPFSAGKRICPGEGLARMEIFLLLTAILQNFTLKPVISPEELSITPTLSGTGNVPPYYQLCAFPR
Protein: BTB domain-containing protein (Q388K1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIAMSWIQQNLGLDVTGEMAQQLSLNVGGVLYLTRRETFRKLRDHQLFGPMFSGTGRQGEDGSFIIDRDGLTFRYVLNFLRSGTLNLPEGFDEWDQLLDDVRYYQLPEMEEAILGCFEYQRCVFRRTLPQAVFVRWHSAGNTNSGVIIEPQLPALEPVEGSQEVRYQGKVLTTIDELITILLSAYGYIIQHWNEQEGRLHLSLGPS
Protein: Serine/threonine-protein phosphatase PP-Z2 (EC 3.1.3.16) (P33329)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the maintenance of cell size and integrity in response to osmotic stress.
Interaction partners:
- Serine/threonine-protein phosphatase PP-Z1
- Protein phosphatase 1 regulatory subunit SDS22
- Phosphopantothenoylcysteine decarboxylase subunit SIS2
- COMPASS component SWD2
- Type 1 phosphatases regulator YPI1
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- GLC7-interacting protein 2
- Polyadenylation factor subunit 2
- Serine/threonine-protein phosphatase 1 regulatory subunit PIG1
- Phosphopantothenoylcysteine decarboxylase subunit VHS3
Sequence:
MGNSGSKQHTKHNSKKDDHDGDRKKTLDLPPLTKSDTTHSLKSSRSLRSLRSKRSEASLASNVQAQTQPLSRRSSTLGNGNRNHRRSNNAPITPPNNHYLTSHPSSSRRLSSSSRRSSMGNNNNSELPPSMIQMEPKSPILKNSTSMHSTSSFNSYENALTDDDDDRGDDGGESPSMAKVTRINTSSSADRGSKRTPLRRHNSLQPEKGVTGFSSTSSKLRRRSDNTLPASYPLNAEAGGNGSDYFSNRSNSHASSRKSSFGSTGNTAYSTPLHSPALRKMSSRDNDDSGDNVNGRGTSPIPNLNIDKPSPSASSASKREYLSAYPTLAHRDSSSSLSPRGKGQRSSSSSSSSQRIYVSPPSPTGDFVHGSCADGDNGSRTNTMVEMKRKKPVRPVDIDEIIQRLLDAGYAAKRTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLDSTALKQVMKKGRQERKLANR
Protein: Sulfopyruvate decarboxylase subunit alpha (EC 4.1.1.79) (P58415)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.
Interaction partners:
Sequence:
MRGSLAIYNALKDSNIDFICSVPCANLKNLLKLIEEDKNIINIPATREEEAFGICAGAYLAGKKTAILMQNSGIGNSINAIASLYKTFQIPTLLIISHRGDLKEQIPAQIPMGRWIEKLLDVCEIPTYKPKTPEEAYKLIKYASSYMYKISYPVALLFDALYWEYDLEK
Protein: Type IV secretion system protein VirB6 (Q9RPX9)
Organism: Brucella suis biovar 1 (strain 1330)
Function: The VirB system could be required for the establishment of the replication niche in the host.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MVNPVIFEFIGTSIHNQLNNYVTMVASNTMNMIATTAVLAGGLYYTAMGILMSVGRIEGPFSQLVISCIKFMLIAAFALNISTYSEWVIDTVHNMESGFADAFAGNHGTPSSTIYQTLDNSLGKGWNIAAMLFEKGDNRGLTQIVQGFSELLLSFLVAGSTLILAGPTGAMIVATNAVIAILLGIGPLFILALGWAPTRGFFDRWFGAIVTSILQVALLSAVLSISSAIFSRMVAAINLASATQSTLFSCLSLTAVTIVMPYMMYKVYEYGGILGSSISAATISLGSLAVNTATSGGGAMTSIFSGSSGGGGSGSAKAGGESSYSAGGNAMWSPAYRQHVLGQFNRD
Protein: Calpain-like protein, putative (Q4GZ05)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGCIQSTVSYKNGQPNFKGATEVHSMFNGLLFRLSDTKNKRWAFYNDSPCYTIHVAILFDFDTQILPLGSTTAFRIDEPRPGREGDRGKYLAEVDVPPLSTELFVEGEVTQWNVDTLEARTAGSEEQYRL
Protein: Protein jagged-2 (Jagged2) (Q9QYE5)
Organism: Mus musculus (Mouse)
Function: Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 4
- Protein jagged-1
- Recombining binding protein suppressor of hairless
- Microfibrillar-associated protein 5
- Hairy/enhancer-of-split related with YRPW motif protein 1
- Mastermind-like protein 1
- Mastermind like transcriptional coactivator 2
Sequence:
MRARGWGRLPRRLLLLLVLCVQATRPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPDEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPDQYLCACPDGYLGKNCERAEHACASNPCANGGSCHEVPSGFECHCPSGWNGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCLPGWKGINCQININDCHGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYDKCASSPCRRGGICEDLVDGFRCHCPRGLSGLHCEVDMDLCEPSPCLNGARCYNLEGDYYCACPEDFGGKNCSVPRDTCPGGACRVIDGCGFEAGSRARGVAPSGICGPHGHCVSLPGGNFSCICDSGFTGTYCHENIDDCMGQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRSGPRCQEVVIFTRPCWSRGMSFPHGSSWMEDCNSCRCLDGHRDCSKVWCGWKPCLLSGQPSDPSAQCPPGQQCQEKAVGQCLQPPCENWGECTAEEPLPPSTPCQPRSSHLDNNCARLTLRFNRDQVPQGTTVGAICSGIRALPATRAAAHDRLLLLLCDRASSGASAVEVAVSFSPARDLPDSSLIQSTAHAIVAAITQRGNSSLLLAVTEVKVETVVMGGSSTGLLVPVLCSVFSVLWLACVVICVWWTRKRRKERERSRLPRDESANNQWAPLNPIRNPIERPGGSGLGTGGHKDILYQCKNFTPPPRRAGEALPGPAGHGAGGEDEEDEELSRGDGDSPEAEKFISHKFTKDPSCSLGRPARWAPGPKVDNRAVRSTKDVRRAGRE
Protein: Interferon gamma receptor 1 (F6NZK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Interferon gamma receptor 2.
- Interleukin 10 receptor, beta.
- Interferon gamma related precursor
- Interferon gamma 1.
- Cytokine receptor family member B12
- Cytokine receptor family member b2
- Signal transducer and activator of transcription.
- Tyrosine-protein kinase JAK1
- Cytokine receptor family member b4.
- Interferon
Sequence:
MLDTNSVVIIMRILICLIVLVFIPRSASQAVSQPSFSHPSPANLSILCDNYGVEIRWDYPDTRHGVSFQVEVNDQLKQRKRDETTNRFLNISRLLSRAAYNDYNVTVKALWNEHRLISSSSIQFTFNQHGSSKIKCRLDFPEVKLSPRNNKLHVQFINPLHLYRNTPVLGNLTEHLTYFITTDTDSKEFTCKINNRTCEAYMSFPEIQDRYCVYLDGDIGQISFNNIRSCYTGELRDYPPTTVFLYSLLGVCVTLLVITGIILLLVKKCNAEIKKKASSAFPAFLEDMKSSNRNPLENKPENVFSTVLIEPADPKPKEQALLLEDSNELEQLYGSTDVENTDTDTKSTTAGSVILDDELDELQDGYDCPHALKVEIDNGDIVDAYGPRGEVLDL
Protein: 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (DAROPP reductase) (DARP reductase) (EC 1.1.1.302) (2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase) (2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase) (DARIPP synthase) (MjaRED) (Q58085)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Catalyzes an early step in riboflavin biosynthesis, the NAD(P)H-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate. The beta anomer is the authentic substrate, and the alpha anomer can serve as substrate subsequent to spontaneous anomerization. NADPH and NADH function equally well as the reductants. Does not catalyze the reduction of 5-amino-6-(5-phospho-D-ribosylamino)uracil to 5-amino-6-(5-phospho-D-ribitylamino)uracil.
Interaction partners:
- 6,7-dimethyl-8-ribityllumazine synthase
- 2-amino-5-formylamino-6-ribosylaminopyrimidin-4
- 3,4-dihydroxy-2-butanone 4-phosphate synthase
- UPF0292 protein MJ1624
- Dihydroorotate dehydrogenase B
- Uncharacterized protein MJ0670
- Pyruvate carboxylase subunit A
- Peptide chain release factor subunit 1
Sequence:
MVMVMEKKPYIISNVGMTLDGKLATINNDSRISCEEDLIRVHKIRANVDGIMVGIGTVLKDDPRLTVHKIKSDRNPVRIVVDSKLRVPLNARVLNKDAKTIIATTEDTNEEKEKKIKILEDMGVEVVKCGRGKVDLKKLMDILYDKGIKSILLEGGGTLNWGMFKEGLVDEVSVYIAPKIFGGKEAPTYVDGEGFKTVDECVKLELKNFYRLGEGIVLEFKVKK
Protein: Receptor-transporting protein 1 (3CxxC-type zinc finger protein 1) (P59025)
Organism: Homo sapiens (Human)
Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.
Interaction partners:
- Receptor expression-enhancing protein 1
Sequence:
MRIFRPWRLRCPALHLPSLSVFSLRWKLPSLTTDETMCKSVTTDEWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQSPYVVILFHMFLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKSQDQTGSGWNFCSIPWCLFWATVLLLIIYLQFSFRSSV
Protein: G-protein coupled receptor 4 (Q8BUD0)
Organism: Mus musculus (Mouse)
Function: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)/H(+).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P46093}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lysophosphatidic acid receptor 1
Sequence:
MDNSTGTGEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVRQHNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYSNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMERWVAWMNLYRVFVGFLFPWALMLLCYRGILRAVQSSVSTERQEKVKIKRLALSLIAIVLVCFAPYHALLLSRSAVYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASNKPQEMANASLTLETPLTSKRSTTGKSSGAVWAVPPTAQGDQVPLKVLLPPAQ
Protein: Probable methanol dehydrogenase transcriptional regulatory protein MoxR3 (O53314)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible conserved secreted protein
- Uncharacterized protein
- Protein-glutamine gamma-glutamyltransferase-like C-terminal domain-containing protein
- Possible integral membrane protein
- Probable transcriptional regulatory protein
- Uncharacterized HTH-type transcriptional regulator Rv0377
- Possible transcriptional regulatory protein
- HTH hxlR-type domain-containing protein
- Transcriptional regulatory protein KdpE
- Probable hydrogen peroxide-inducible genes activator
Sequence:
MIMPAATTTAHCEAVLDEIERVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFTRVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLPEAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQVTVHEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDVKELATAAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT
Protein: LD31045p (Pleiohomeotic like, isoform A) (Pleiohomeotic like, isoform B) (Q9VSZ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Polycomb protein Sfmbt
- Polycomb protein Su
- Polycomb protein esc
- Histone-lysine N-methyltransferase E
- Polycomb protein esc
- Chromatin assembly factor 1 p55 subunit
- E3 ubiquitin-protein ligase RING1
- Protein suppressor 2 of zeste
- Pipsqueak, isoform M
- Polycomb group protein Psc
Sequence:
MTSHHHHVGVGGNFQPQLHQIRAPIVKNLSLAAAAVPLPLHSAPSSAYFTHAHQPTAATIVEQDPYTVLAGDPMGEESESFLIEEIIDDYDDEANIVVDSGEFFEHYEYYPVDRLDRLTSVTVATADALPPPIIMQQTSDDEEFIEEDGQQMTSSCDGDGDEDDEATAPATTNAFEIASEMLTTIEATNIKEEQLESDFYMKATEDSNSSNGQLQDFKLFGSSRVERPMGNSAAKRWKQTKVPIRITQDEFNVTLWSSLNSEDEDEEEELEEPPGCAGTTSVTSSSAAQNEGSPSMPKLIIDEHMINHDVLSDGIGNEYVILPDPFSASAVTDVEEVVNAFMGDVKGEEDSQPLSEQLIYAENQLEEAYGNIELIENMPNNVELIQTPGPGPATVSVALSKVNGCVPNPQPALPKLVLQNSSTNVRLKSAGNQSKVTKRQLTAAAQVATPNPPPPLVASSNPARPQRPTIVTKLPTAVANQTAGNAMGAAGAAGEEDEEPKFRCTHRGCNKEFRNHSAMRKHMHTHGPRGHVCNVCGKSFVESSKLKRHQLVHTGEKPFECTFEGCGKRFSLDFNLRTHVRIHTGDRPYHCPIDGCSKCFAQSTNLKSHMLTHTKPKRKWPRAPQVSNNKTPLVARYGRLEFGEDPRLVYVEQNEEVASVLLDGTSLTS
Protein: NBPF family member NBPF9 (Neuroblastoma breakpoint family member 9) (P0DPF3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVAEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQIEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEREDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTPSIPPEMLASYKSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRWYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDLDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEENQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (A0A1D8PJ80)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Type 2A phosphatase-associated protein 42
- Protein phosphatase 2A structural subunit
- Protein phosphatase PP2A regulatory subunit B
- Protein phosphatase methylesterase 1
- Leucine carboxyl methyltransferase 1
- Anaphase promoting complex subunit 1
- Serine/threonine-protein phosphatase 2A activator 1
- Serine/threonine-protein phosphatase 2A activator 2
- Serine/threonine-protein kinase
Sequence:
MDLDTDVPMEDVEEQQQQQEQSLSKQSATKSLTNPQGTGATATSSAQQQRKDLDGSSINQLDVWIEKLSKCEPLSETDVKKLCDMAVEVLQFEENVQPVQVPVTICGDVHGQFHDLMELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVCMKVRFPNRITILRGNHESRQITQVYGFYDECLRKYGSATVWKLFTDLFDYFPITALVDNKVFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGFSWSHQENVVTIFSAPNYCYRCGNQAAIMEVDEQHNRQFLQYDPSVRPGEPTVTRKTPDYFL
Protein: Fibroblast growth factor (FGF) (Q9VDT9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Fibroblast growth factor receptor homolog 2
- Fibroblast growth factor receptor homolog 1
- Tie-like receptor tyrosine kinase
- Cytosolic beta-glucosidase
- Syndecan
- Protein hedgehog
- Pyramus
- Thisbe
- FI03681p
- Protein wingless
Sequence:
MRRNLRLDWRALALLGALLSFIIAWRGLVSAMPLMAMDNNLTDSSGSTNTSTSSTSKYNSTNNSNLFSNSYLQSDHSRSSLVPSAVSERSVNQPTNQSINAEFNQSLSTHPTAITSTPQTQTQTQIQSQYPSQAEDSDQLEEPLGFVISAMPNEHLAVLSRTERSIRHQNQQQQKKHHHHHQQQQQQQHQQQQPMSPADNNFIGSKSKRLSNPRSSLNINSSSSNTPISNLDRNERSTVPQSHLAWTSRKIQLYIKNRILQILRDGVVNGTQDENSEFTILQRSTVDVGRIKLQSVATCLYLCMDACGVPYGSKDFTDDCVFNENMGLQNYNTYSSTYHSQARRVFYLALNGSGQPRRTQIPASRSLGKLSTYTNAITETVPQERVEQLIAKNFGANRVKHGVRQLCDTGKPLIELIDVARFKAPPHCSSNTSGSSSSISSSSSSSSKSSSNSSSSYVPVSAISSLSSISNSSQSESGHISSSLSGSSNSNSSSNSSSSNSSSNSSRPSGSKANKKKKPKCKPHEQEDTHNCQKRGGAGAGALRKLGPKAKRCKELREKAAAEKRAPPNCGKKNGARKNPTEAAKAVQQRPKGNIQHGGKKKPNKAGKQRQNGGKKQQQQQQHQLQQQPLQHQAKSISGGKRKHRKLDASTTTTMATSLGTPPSSHWESSSPLPAFSLSETSDRVERNVRMSSGEEQDQDNDQDQEQSDPGEQGEEETEGDGGSLEDASYEDSSSEAQGRSGAGGDDSLYYDFLCLQLIAMVLLRKRAIL