wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor ets-4 (A8WFJ9)
Organism: Caenorhabditis elegans
Function: Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too has been implicated in the control of fat accumulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:20862312}.
Interaction partners:
- CCAAT/enhancer-binding protein homolog 1
- Endoribonuclease rege-1
- cAMP-dependent protein kinase catalytic subunit
- MAP kinase-activated protein kinase mak-2
- Tyrosine-protein kinase receptor svh-2
- 5'-tyrosyl-DNA phosphodiesterase
- Serine protease svh-1
Sequence:
MNGTGSVGHRWNSLSPEPHSGTESTASTPFVKSEFPFDDDLFGIDQVNNVKPHPMDMPCNLPIQPIEYNRRFSKDADHSTFVKNEIEENILNFNVNPEIAQDNGLDTQQIDIYRDLILRHLIQDISTTCAKLGLPNDFYLWSSEHGARWINEMCMQFNLQPPRNCSITGIDLLGMSQKDFEMILPAGGDTLHAQLQVWKTGTSDYVKAFENYHPPVTVQSSGMTAAENNMQSKTNWLASTNNQTNNMAAAENPNHPFFNGNGGYPNMSMSSFFQQGTVLPSPSNSDTSSNGSSQDMNDDDIDLHMNNSNCGFSNFFHNQGYMNSPIDAMCNGSEGDDDERAYTRHQGTVHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKFLPPYNL
Protein: Somatotropin (W5ULR0)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MARVLVLLSVVVASLLFSQGATFESQRLFNNAVIRVQHLHQLAAKMMDDFEEALLPEERKQLSKIFPLSFCNSDSIEAPAGKDEAQKSSVLKLLHTSYRLIESWEFPSRNLGNPNHISEKLADLKMGIGVLIEGCVDGQTGLDENDSLAPPFEDFYQTLSEGNLRKSFRLLSCFKKDMHKVETYLSVAKCRRSLDSNCTL
Protein: Alpha-S1-casein (allergen Bos d 8) [Cleaved into: Antioxidant peptide] (P02662)
Organism: Bos taurus (Bovine)
Function: Important role in the capacity of milk to transport calcium phosphate.
Subcellular location: Secreted.
Interaction partners:
- Alpha-S2-casein
- Beta-casein
- Kappa-casein
- Alpha-lactalbumin
- Beta-lactoglobulin
- Glycosylation-dependent cell adhesion molecule 1
- Chymosin
- Lactotransferrin
Sequence:
MKLLILTCLVAVALARPKHPIKHQGLPQEVLNENLLRFFVAPFPEVFGKEKVNELSKDIGSESTEDQAMEDIKQMEAESISSSEEIVPNSVEQKHIQKEDVPSERYLGYLEQLLRLKKYKVPQLEIVPNSAEERLHSMKEGIHAQQKEPMIGVNQELAYFYPELFRQFYQLDAYPSGAWYYVPLGTQYTDAPSFSDIPNPIGSENSEKTTMPLW
Protein: Expressed protein (Translation initiation factor) (Q8S8F1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GDT1-like protein 5
- Protein ABC transporter 1, mitochondrial
- Oxaloacetate tautomerase FAHD2, mitochondrial
- Probable leucine-rich repeat receptor-like protein kinase At5g49770
Sequence:
MAAITGFSALSNHISPASSLPSSRLLNSTQCLSRFSNVSSFPALSTFRRRKIPLTPACSSIVDGDEEIEARGDDENEIRETLMLSVSPLPLLLVASLPGAETVRSVFGPVVEIVKSLNLPDWLVHWGHPGNMAVVLFAMGGYGTYLGFRIRYSDDIEEKAKAKDLHPKLLAGMFFFFALGATGGVISLLTSDKPIFESPHAVTGLIGLGLLTVQTILPSLFKEKPELRNVHGILGSGIMALFLVHAAFGLQLGLSF
Protein: Maltase-glucoamylase (EC 3.2.1.20) (B5THE2)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Pancreatic alpha-amylase 2a5
- Alpha-amylase 1
- 1,4-alpha-glucan-branching enzyme
- Glycogen phosphorylase, liver form
- Sucrase-isomaltase, intestinal
- Glycogen debranching enzyme
- Glycogen phosphorylase, muscle form
- Glycogen phosphorylase, brain form
- Neutral alpha-glucosidase C
- Hexokinase HKDC1
Sequence:
MAGRRFKKFSKLELVLIVLLLVLFIIAVVLIVLLANSTPENAIGAETTGTPDTTVTRTTLNSPNCPVLSELERINCIPDQSSNKGTCDERGCCWDPQGSISVPCYYSRNHGYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKSNNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWTLGFQLSRYDYKSLDNMKAVVERNRAAQLPYDVQHADIDYMDQKKDFTYDPVNFKGFPEFVKELHNNGQKLVIILDPAISNNSFSSNPYGPYDRGSAMKIWVNSSDGISPVIGKVWPGTTVFPDYTSPNCAVWWTKEFELFHKEVEFDGIWIDMNEVSNFIDGSFSGCSQNNLNYPPFTPKVLDGYLFSKTLCMDAVQHWGKQYDVHNLYGYSMAIATAKAVKDVFPDKRSFIITRSTFAGSGKFAAHWLGDNTATWKDLQWSIPGMLEFNLFGIPMVGADICGFAQDTYEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGNNSLLLNSSRHYLNIRYTLLPYLYTLFYRAHSRGDTVARPLLHEFYDDNNTWGIDRQFLWGPGLLITPVLDQGAEKVKAYVPNATWYDYETGEELGWRKQSIEMQLPGDKIGLHLRGGYIFPTQQPATTTEASRKNPLGLIVALDENKEARGELFWDDGESKDTVAQNIYLFSEFSVTQNHLDVTISSPNYKDPNNLEFQEIKIFGTREFRNVRVKQNGNLLQMSPQVTYNPNLKVATITNIHLRLGEAYTVEWDFFTREEERIDCYPDEHGASEANCSARGCIWEASNTTRGPPCYFAHELYSVSNVQYDSHGATADISLKASTYSNAFPSTPVNKLKLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPLSTPEGRLYDVLIKENPFGIQIRRKTTGTVIWDSQLLGFTFNDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTIGGILDFYVFLGPTPEIVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDTEIANLYDEMVAKQIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRINTDQYYLARFSVNQTTLLTHEKFNNYLTGTAPLYLGYIDIWGLSSSSITNVSISWNTNNEEVFANYNSTTKILSVNMTDKKISLHTFNSLTWSSS
Protein: Transaldolase (EC 2.2.1.2) (Q9EQS0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q93092}. Cytoplasm {ECO:0000250|UniProtKB:Q93092}. Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1. {ECO:0000250|UniProtKB:Q93092}.
Interaction partners:
- Transketolase
- transketolase
- transketolase
- Glucose-6-phosphate isomerase
- Fructose-1,6-bisphosphatase isozyme 2
- Fructose-1,6-bisphosphatase 1
- Triosephosphate isomerase
- Triosephosphate isomerase.
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase, muscle type
Sequence:
MSGSPVKRQRMESALDQLKQFTTVVADTGDFNAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGKKLGGPQEEQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRIIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPQEDPGVKSVTKIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLKDSSKLAPTLSVKAAQTSDLEKIHLDEKAFRWLHNEDQMAVEKLSDGIRKFAADAIKLERMLTERMFSAENGK
Protein: CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase) (Q8L6Z9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKYVLVTGGVVSGLGKGVTASSIGVVLKACGLGVTSIKIDPYLNTDAGTMSPFEHGEVFVLDDGGEVDLDLGNYERFLDVTLTKDNNITTGKIYQSVLDKERKGDYLGKTVQVVPHITDAIKDWIESVSLIPVDGKEGQADVCVIELGGTVGDIESMPFIEALRQLSFSVGPDNFCLIHVSLIPVLGVVGEQKTKPTQHTVRELRALGLTPHFLACRSAQPLLESTKAKLSQFCHVAAANILNIHDVPNIWHVPLLLRNQNAHHSILKQLNLTNVATAPDLDSWNKMAETFDNLTNHVQIAMVGKYIGLTDSYLSVVKALLHACIACSLKPHIEWIAASDLEDESEKSTPEAHAAAWKILKSAECILVPGGFGDRGVSGMVLAAKYARENKIPYLGICLGMQIAVIEFARSVLGLERANSTEFDAQTSDPVVIFMPEGSRTHMGSTMRLGSRRTHLHNRDSLTSKLYGQVSYVDERHRHRYEVNPEVAQALEEAGLRFVGKDDTGKRVEVIEFQDHPFYVGVQFHPEFKSRPTRPSPLFLGFILAARKLLQAHLSN
Protein: Cutinase CUT2 (EC 3.1.1.74) (G4MZV6)
Organism: Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae)
Function: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle. Required for efficient penetration of the host plant cuticle by the appressorium during the initial stage of fungal infection.
Subcellular location: Secreted {ECO:0000269|PubMed:17704215}.
Interaction partners:
Sequence:
MQFSLSIATAILAATASAMPVLETRQTVGTTANEFTSGGCKDVVLLYARGTTQAGNMGQEPGPELGNALKARLGAARVAVQGVAYSASLLGNLNPGGAPANEATSFRTLIGQVASQCPNARIVVSGYSQGAALVHRAVEGATAAVRARIAAGVTFGDTQKQQDGGRIPGLDASKTLIICNTGDRVCEGTLIITAAHSGYGARAGEAVDFIAARV
Protein: Antimicrobial peptide 3 (Levitide-like peptide) (XT-3) (P84383)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Has antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli, when in combination with XT1 and XT6.
Subcellular location: Secreted {ECO:0000269|PubMed:11738090}.
Interaction partners:
Sequence:
GLASTLGSFLGKFAKGGAQAFLQPK
Protein: Trafficking kinesin-binding protein milt (Protein milton) (Q960V3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for kinesin-mediated axonal transport of mitochondria to nerve terminals. The oocyte acquires the majority of its mitochondria by competitive bidirectional transport along microtubules mediated by the Milton adapter. Mitochondria enter the young oocyte en mass from interconnected germ cells to generate the large aggregate known as the Balbiani body. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12495622, ECO:0000269|PubMed:16717129, ECO:0000269|PubMed:16887820}.
Interaction partners:
- Mitochondrial Rho GTPase
- Kinesin heavy chain
- Serine/threonine-protein kinase Pink1, mitochondrial
- Uncharacterized protein, isoform E
Sequence:
MTHVNNGEVMEKEMEPTGERERDRETAAGSGVHHRFLASASERDANSGNALEAAATKTKTGTTITNLEDLAFEACQNWSDLHQDFFITDDELEYEDELSLGSSIGGNIATTTTADAAVEGLITGEHQNEQLLMEVLCGNRVSQMTRAYDDIEAVTRLLEEKEKDLELTVQIGKELLTQNNALEARVADLETDLKASNDDRAQLVHELHKKNELISVLTNDADDGTDTDTPTMSKSITLDLLQRKVNSLLDENKSLKCEATQLAHQTDEVEEHERQLMADISAQLNDANSQYDNLSLELERQREENRLQHEQIVNLTARLAEAEMRLHQLTQDNDEHLSLLHVTKENQNALALELVEFKQRYEEVLALLHSAQDQLKQQRKRSQPQARSSFLGGLGTSGAGMGGSLFPPDSLHCELMESSLYSENSLDSGISGDSQRSADRISRMMMHMPSGGMSSSTMGGSVYAGAGNVPPYKRVFDTVRCAGKSGNYMDSGNVSMTQLGAMSMSSSSGPRMASMAYPAGSYYRGGSNQSLGVKTLSSESLNSQSDDGYPAQPSGVPGAPGAKELEAALKRLTPAEVLARRAMLSYAPAGTYNYDEPMGHGTGNVRNSDLPLGVRTPDSIMSTGSSGMSGSTNHMSASMTHQWRLPEKLQIIKPMEGSQTLHHWSRLATPTLSGLLDERPGVTIRGGRGLDDLGMQIYTLSDVEEDVSDDLPGKQFEAPGCTFTYTNSMVMHPDDGFVNDLSFLSQSQMSSRMASTSTSRQPSCPATPRAGLSRKNSCSTFSVNLGLAGMLNERGIKAVTPSALNTPAGPNFSPTVTPCNSPEGSPPRAQSPEPLFGLLSCGADLIRRKIVGDQHQQQQQKQRSSLSKQQQQKIMLSHLERRALRSLNLIEKVESIGLENIISAQRGLGSGIANRSSSPLSSGSLQSLHTSSNSIVDDIHFDRAQIKGVLHRGLKSPTPATASTSAAAAASGPGISTSSSTSAYNSDDSDDQGLVMKIKPSKSATPTTTGAAQSQPSSATTSNGTASETRLKQMQRQKSRRQLKNGMANQRPDLGTISGAGGGGRVRPDLGKVADSGSSSKLSTKRSEAKPAEEEEATPQTITQAFVGSVSSLLFGRKGGWL
Protein: Dof zinc finger protein DOF3.1 (AtDOF3.1) (Q94AR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- At2g34340
- Two-component response regulator ARR22-like protein
Sequence:
MQDPAAYYQTMMAKQQQQQQPQFAEQEQLKCPRCDSPNTKFCYYNNYNLSQPRHFCKSCRRYWTKGGALRNVPVGGGSRKNATKRSTSSSSSASSPSNSSQNKKTKNPDPDPDPRNSQKPDLDPTRMLYGFPIGDQDVKGMEIGGSFSSLLANNMQLGLGGGGIMLDGSGWDHPGMGLGLRRTEPGNNNNNPWTDLAMNRAEKN
Protein: Calmodulin-dependent protein kinase (Q59XV1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Calmodulin
- Mlc2p
Sequence:
MSTDHHSHPVEGHQFKKIFNRLSGQPESYSRKQNYTFGKTLGAGSFGIVRYARDNSTDEEVAVKIILKKALKGNESMIIDEMQLLEQLNNPHIVGFRDWFESKDKFYLVTQLATGGELFDRIVQKGRFTEHDASLVVLQMLEALEYLHNKDIVHRDIKPENILYLTSKDDSPIVLADFGIAKRLQNPNEKLTSSAGSFGYAAPEVILGTGHGKPCDIWSLGVVTYTLLCGYSPFRSENVQDFINEVKHNNAVIFHADYWKDVSKDARRFIIKALQFNPDNRPTATELLNDPWLVSIAKEYKETDLLPNFKQGFDAKKKFRQAIELVKLNNRIKKLKEWQTDEDDDPTEINLFNEHGSVEQRANPSTNDGLTIPGTTSPRRGESPLNTWKKFNDVINSLDTNRSKASLSSFKSPYDLAHSNRGTDVSNSGATNVGKSDTASSAFVQLVHAATANKEKVANYTEDEEGKEKKQKDGDKN
Protein: Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) (O75936)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Subcellular location: Cytoplasm.
Interaction partners:
- T-cell receptor-associated transmembrane adapter 1
- E3 ubiquitin-protein ligase TRIM17
- 4-trimethylaminobutyraldehyde dehydrogenase
- Aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase X, mitochondrial
- Aldehyde dehydrogenase family 3 member A2
- Alpha-aminoadipic semialdehyde dehydrogenase
- HMG box transcription factor BBX
- General transcription factor 3C polypeptide 1
- E3 ubiquitin-protein ligase TRIM9
Sequence:
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVENGN
Protein: FA complementation group C (Fanconi anemia complementation group C isoform 2) (A0A0S2Z3N5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQVELY
Protein: KIF-binding protein (KIF1-binding protein) (A8WE67)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96EK5}.
Interaction partners:
- Kinesin family member 15
- plus-end-directed kinesin ATPase
- Kinesin-like protein
- plus-end-directed kinesin ATPase
- Kinesin-like protein
- Guanine nucleotide-binding protein-like 1
Sequence:
MAANNSIEWRAVCEKFRLAQELSEIESKKDPENNPFRSKYKARDLLKEIHCSLKKIEIEEQGEAGDEADCESSQTADGEPEDGFEKTFTGDSAAGLRAARLAVLQYHLGVNHIETEELSAGELHLMVCMKLIDKCTTTRENVSLFIHVRNQLGILWAGRDEIEKAQGFLEIAETMYLVYMKEDGQPPLDLQDFFVPEGEELSQQEKIRRFEMAYTHTLYYLAQVYKNLQQYERAAQYCHSTLQRQLEYKQFAPLEWAINAATLSQYYITKTRYMEARHCLAAASVIANLAGEIPSEAAAKESEAESEKREELLQKRAEIARCWIKYCLNLLQDAKKLLEDNIGELDLDRQDELKRARRNEEEEKEKGRKSAILFGSSDTFDSICSLEEKVSSMLPLEFEEARSIFLVGQSYVTQAKEYFAMDGHVTDHIEILQDHSALFKVLAFFEEDLERRCKMHKRRVDMLEPICKDLNAQYYLLICRQLQFELAETYYEMMDLKLAVADKLDQPDVHTIKKFNHLCSSSMKYYQMFLDSTRSPEGKFPEKLEDDLLRPALVAKFRVARLHSKLISSNLATQMENLSLSLESYNFVVQYCEENPEAKNAVETELELSMEMVSLLPLKINRIRSTLASSK
Protein: Phosphoinositide phospholipase C 9 (EC 3.1.4.11) (Phosphoinositide phospholipase PLC9) (AtPLC9) (PI-PLC9) (Q6NMA7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- At4g10470
- Non-specific phospholipase C1
- Non-specific phospholipase C6
- Non-specific phospholipase C5
- Non-specific phospholipase C4
- Non-specific phospholipase C2
- ATP synthase subunit a, chloroplastic
- Cysteine/Histidine-rich C1 domain family protein
- AT4g01920/T7B11_18
- Pentatricopeptide repeat-containing protein At5g15300
Sequence:
MVNLRKKFEMKQANQPGRVPNYFRNKYHGYDDDMPNLLPTFIKLLDTEKDEDGAGLNAAEQIDRELKSRKCDILKFRNLTILELPHLNEFLFSTELNPPISDQVRHRDMNAPLSHYFIHTSLKSYFTGNNVFGRLYSIEPIIDALKQGVRVVELDLLPFGKDGICVRPKWNFEKPLELQECLDAIKQHAFTPTRSYPVIITIKDSLKPDLQSKVTQMIDQTFGDMVYHEDPQQSLEEFPSPAELQNKILISRRPPTKLLYAKAVENGVELEIQEGSTDKNYQSVVGFHAVEPRGMLQKALTDDVQQPGWYERDVISFTQNKFLRTRPKKRNLLSNPPYKPQRAWMHGAQMIALSRQDDKEKLWLMQGMFRANGGCGYVKKPNFLLNAGSSGVFYPTENPVVVKTLKVKIYMGDGWIVDFKKRIGRLSKPDLYVRISIAGVPHDEKIMNTTVKNNEWKPTWGEEFTFPLTYPDLALISFEVYDYEVSTPDYFCGQTCLPVSELIEGIRAVPLYDERGKACSSTMLLTRFKWS
Protein: Histone deacetylase (EC 3.5.1.98) (Q08BS8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037911}.
Interaction partners:
Sequence:
MVDVSVALPLQVPPSAIPMDLRVDHQFALAPTDPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKHQQDLLALKHQQELLEHQRKLGRHRQEQEMEKQQREQKLQLLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRSLNHCLPSDPRYWYGKTQHSSLDQSSPPQTGISTYNHPVLGMYDPKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTAKKRSLDMAESACSSAPGSGPSSPNNSSNNITNENGIAGSISNSAVEPSLAHRLTGREGPVSQLSLYTSPSLPNITLGLPATGPSSVASGQQDGDRMAVPGLQPGIPITTPFMPGAHLPSYLAASSLERESGSAHNTLLQHMVLLEQSAAQNSLVAGLSGVPLQSHSIHKLRQHRPLGRTQSAPLPQNSQALQQLVVQQQHQQFLEKHKQQFQQQQLHISKMMVKPSEPNRQHESHPEETEEELREHQGLGDPADPLPHGVTIKQEPPDEQDEDFQQRERQAEEELLFRQQALLLEQQRIHQLRNYQASMEAAGLSVSFPVHRPLSRAQSSPASATFPIVVQEPPAKPRFTTGLVYDTLMQKHQCMCGNSNIHPEHAGRIQSIWSRLQETGLRGQCECIRGRKATLEELQTVHSEAHVLLYGTNPLRQKLDSSVTPMFVRLPCGGIGVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASGELRNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGSGAPDEVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAFRSVVMPIANEFSPDVVLVSSGFDAVEGHPPPLGGYKLTAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELDPIPEDILQQRPNANAIQSMEKVLEVQSKYWRSLQRSVSTLGYSLREAQRCENEEAETVTAMASLSVANKHMGKRPEEEPMEEEPPL
Protein: T cell receptor beta variable 12-3 (T-cell receptor beta chain V region YT35) (P01733)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular location: Cell membrane {ECO:0000303|PubMed:20452950}.
Interaction partners:
Sequence:
MDSWTFCCVSLCILVAKHTDAGVIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSEPRDSAVYFCASSL
Protein: GM03574p (Q95SC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRRRGNLCPITILPLGRSVQSASKRINIFGVKDVDYVKSLSKALEPMLKDESQYQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPLRHYASAASKSFADNWSLKTDYVYTPPCPGCVDCAATVQRQETAQPSGLFTRGLIKYKNNPGETKRPLVKNDNCSKKFEGSAEASQININCVQNKDNFAELESQFISSLQPGWEFIKQIPEVTCSKILPSLVVKSRTIQLHPDGEMGEKFYSIDGEEYDARPIKVSVVPNAIKVFC
Protein: Uroplakin-3a (UP3a) (Uroplakin III) (UPIII) (O75631)
Organism: Homo sapiens (Human)
Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.
Interaction partners:
- Uroplakin-1a
- Uroplakin-2
- Uroplakin-1b
- Keratin, type I cytoskeletal 20
Sequence:
MPPLWALLALGCLRFGSAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD
Protein: AAA-type ATPase family protein / ankyrin repeat family protein (Putative rubisco expression protein) (Q9C5C7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2
- Protein OS-9 homolog
- Ataxin-3 homolog
- NPL4-like protein 1
- NPL4-like protein 2
- Probable ubiquitin conjugation factor E4
- AT3g18860/MCB22_3
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- Derlin-2.1
- Derlin-2.2
Sequence:
MNRQNGGGQRLRSARPTTIHDCALSGDLIALQRLLKDNPSLLNERNPVMYHTPLHVSAGNGNVDIVKYLLAWTGSDKVELEAMNTYGETPLHMAAKNGCNEAAKLLLESGAFIEAKASNGMTPLHLAVWYSITAKEISTVKTLLDHNADCSAKDNEGMTPLDHLPQGQGSEKLRELLRWFLQEQRKRSALEQCGKTKAKMELLEDELSNIVGLSELKTQLRKWAKGMLLDERRRALGLNIGTRRPPHMAFLGNPGTGKTMVARVLGKLLNTVGILPTDKVTEVQRTDLVGEFVGHTGPKTRRKIQEAEGGILFVDEAYRLIPMQKADDKDYGLEALEEIMSVMDTGKIVVIFAGYSEPMKRVIASNEGFCRRVTKFFNFSDFSAKELAQILHIKMNNQGEDTLFYGFRLHESCTLQEIASLIEAETTEKQRKEMNGGLVDTLLVNARENLDLRLSFECVDTEEICTIKLEDLEAGLRVFSQ
Protein: INO80 complex subunit 5 (B8Y7Y5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- INO80 complex subunit 3
- INO80 complex subunit 1
- Actin-related protein 4
- Chromatin-remodeling ATPase INO80
- RuvB-like helicase 2
- RuvB-like helicase 1
- INO80 complex subunit 4
- Chromatin-remodeling complex subunit ies6
- Actin-like protein arp5
- Probable actin-related protein 8
Sequence:
MAAQKKQGERVLPARSTRKRRQLPDMLYYDERTDSYVTPQERSLSEANAQTRPAPNTINQAVDAKQSAREARVQELMKSKLYHLRKQQKQARHKRDQWAIDYLEWKKNEDEDVWNSDAEATGPAEHTSSFLDALRFSQQFMKAE
Protein: Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues) (Q969Z4)
Organism: Homo sapiens (Human)
Function: May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16389068}; Single-pass type I membrane protein {ECO:0000269|PubMed:16389068}. Cytoplasm {ECO:0000269|PubMed:16389068}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22052202}.
Interaction partners:
- Serine/threonine-protein kinase OSR1
- TNF receptor-associated factor 1
- TGF-beta receptor type-2
- Tumor necrosis factor receptor superfamily member 19
Sequence:
MKPSLLCRPLSCFLMLLPWPLATLTSTTLWQCPPGEEPDLDPGQGTLCRPCPPGTFSAAWGSSPCQPHARCSLWRRLEAQVGMATRDTLCGDCWPGWFGPWGVPRVPCQPCSWAPLGTHGCDEWGRRARRGVEVAAGASSGGETRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAHKEVGPGPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVSKLPPAPPNVPHICPHRHHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAVAATTPVPSLLPNPTRVPKAGAKAGRQGEITILSVGRFRVARIPEQRTSSMVSEVKTITEAGPSWGDLPDSPQPGLPPEQQALLGSGGSRTKWLKPPAENKAEENRYVVRLSESNLVI
Protein: Cytochrome b-c1 complex subunit 7, mitochondrial (Complex III subunit 7) (Q5ABS1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00128}; Matrix side {ECO:0000250|UniProtKB:P00128}.
Interaction partners:
- Cytochrome b-c1 complex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Cytochrome c oxidase subunit 8, mitochondrial
- Cytochrome b
- Cytochrome c oxidase subunit
- Cytochrome c oxidase subunit Va
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- NADH-ubiquinone oxidoreductase
Sequence:
MVQSMTSVVKAANFILARPTLSKIITPLAQKFTAYAGYREMGLKFNDLLLEETPIMQTAIKRLPSELNYSRNFRILTAHQLALSHQLLPAEKAVKPEEDDNYLIPYILEAEKEAFEKAELDNIEVKA