wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor tyrosine kinase-like orphan receptor 1 (A0A8I6AEX6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MHRPRRRGTRPPPLALLAALLLAARGAAAQETELSVSAELVPTSSWNTSSEIDKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPNIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATSGKKVVSTTGVLFVKFGPPPTASPGSSRQSNQTRPCEDILPASSLSAGAHERCTRFHSLSTGQAVWVKVTAEGSSGLRSALPQLGSQKPSSTQSTGHLST
Protein: Cellulase (EC 3.2.1.4) (O33897)
Organism: Rhodothermus marinus (Rhodothermus obamensis)
Interaction partners:
Sequence:
MNVMRAVLVLSLLLLFGCDWLFPDGDNGKEPEPEPEPTVELCGRWDARDVAGGRYRVINNVWGAETAQCIEVGLETGNFTITRADHDNGNNVAAYPAIYFGCHWAPARAIRDCAARAGAVRRAHELDVTPITTGRWNAAYDIWFSPVTNSGNGYSGGAELMIWLNWNGGVMPGGSRVATVELAGATWEVWYADWDWNYIAYRRTTPTTSVSELDLKAFIDDAVARGYIRPEWYLHAVETGFELWEGGAGLRTADFSVTVQ
Protein: Pectinesterase 31 (PE 31) (EC 3.1.1.11) (Pectin methylesterase 31) (AtPME31) (Q9LVQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin. Acts in a blockwise manner, resulting in a cell wall rigidification.
Interaction partners:
- Probable pectate lyase 3
- Probable pectate lyase 13
- Probable methyltransferase PMT4
- Pectate lyase
- Pectate lyase
- Probable arabinosyltransferase ARAD1
- Probable galacturonosyltransferase-like 3
- Probable arabinosyltransferase ARAD2
- Probable pectate lyase 12
Sequence:
MATTRMVRVSQDGSGDYCSVQDAIDSVPLGNTCRTVIRLSPGIYRQPVYVPKRKNFITFAGISPEITVLTWNNTASKIEHHQASRVIGTGTFGCGSVIVEGEDFIAENITFENSAPEGSGQAVAIRVTADRCAFYNCRFLGWQDTLYLHHGKQYLKDCYIEGSVDFIFGNSTALLEHCHIHCKSQGFITAQSRKSSQESTGYVFLRCVITGNGQSGYMYLGRPWGPFGRVVLAYTYMDACIRNVGWHNWGNAENERSACFYEYRCFGPGSCSSERVPWSRELMDDEAGHFVHHSFVDPEQDRPWLCLRMGVKTPYSA
Protein: Transcription factor Dp-1 (Q5JSB6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNES
Protein: Proteasome-associated ATPase (AAA ATPase forming ring-shaped complexes) (ARC) (Mycobacterial proteasome ATPase) (P9WQN5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types.
Interaction partners:
- Proteasome subunit alpha
- Proteasome subunit beta
- Prokaryotic ubiquitin-like protein Pup
- CysO-cysteine peptidase
- Glycerol kinase
- Bacterial proteasome activator
- Pup--protein ligase
- Pup deamidase/depupylase
- Serine protease PepD
- Probable serine protease HtrA1
Sequence:
MGESERSEAFGIPRDSPLSSGDAAELEQLRREAAVLREQLENAVGSHAPTRSARDIHQLEARIDSLAARNSKLMETLKEARQQLLALREEVDRLGQPPSGYGVLLATHDDDTVDVFTSGRKMRLTCSPNIDAASLKKGQTVRLNEALTVVEAGTFEAVGEISTLREILADGHRALVVGHADEERVVWLADPLIAEDLPDGLPEALNDDTRPRKLRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYADIGGLSRQIEQIRDAVELPFLHKELYREYSLRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAHEAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYSKYLTEFLPVHADDLAEFDGDRSACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKSSSASRAIDTESNLGQYL
Protein: Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (Q62859)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MACLGLQRYKTHLQLPSRTWPFGVLLSLLFIPIFSEAIQVTQPSVVLASSHGVASFPCEYASSHNTDEVRVTVLRQTNDQVTEVCATTFTVKNTLGFLDDPFCSGTFNESRVNLTIQGLRAADTGLYFCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLVTAVSLNRTLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
Protein: Vomeronasal type-1 receptor (H3BJ46)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}.
Interaction partners:
Sequence:
MSSLSFMSSLLENILYFQAGLGVLANIFLLVFYIFIILGHRPKPMDLISCQLTFVHIMMFLAGENFWLANIFESLNVENDFKCKATFYTKRVMRGLSICITCLLSVFQAVMISHRNSLLAKFKHKLKIYMINALFYIWTFNLSLSSNLIFYVGGFTNMSQTKQLKVTKSCSLIPMNYIIRGLILTVISSRDMFLVGVMLTTSTYMVIILCRHQRQCKHLHSTSHLRASPEKRATQTILLLVVFFVIMYWVDFIISSTSILLWMYDPVIMIVQKFVVNAYPAITPFVQISSDTRVIRVVKNWHS
Protein: Interleukin 17_3 (Interleukin 17c) (Interleukin-17C precursor) (Q5TKT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Interleukin 17_2
Sequence:
MWSPLFFGLLFFWLSESKVEGKHLCFKDCDHGFSKAHQKLLRSLISPRHPPVQPVHHPAGSCEDFVRTASDDLKHRSLSPWRTSISLVFFRTVENPDMYPSKYEEAQCLCDGCIINGELNRSYNSVPVFKTHVFLKKHPCPSDPDKYSFTFEHVQVPVACTCAVPKQ
Protein: ATPase GET3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I) (O43681)
Organism: Homo sapiens (Human)
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9736449}. Endoplasmic reticulum {ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:31461301}. Nucleus, nucleolus {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9736449}.
Interaction partners:
- Guided entry of tail-anchored proteins factor 1
- Golgi to ER traffic protein 4 homolog
- Ubiquitin-like protein 4A
- Guided entry of tail-anchored proteins factor CAMLG
- Large proline-rich protein BAG6
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Syntaxin-5
- Low molecular weight phosphotyrosine protein phosphatase
- E3 ubiquitin-protein ligase RNF126
- Vesicle-associated membrane protein 2
Sequence:
MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSAQ
Protein: SCAN domain containing 3 (Zinc finger BED-type containing 5) (B2RPU8)
Organism: Mus musculus (Mouse)
Interaction partners:
- Fanconi anemia group M protein homolog
Sequence:
MPRGSRIRTSRVTLLAGRAPQMRAAPRRAPAAQPPAAAAPSAVGSPAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGGSAEPAKPDITYQEPQGAQLQNQQSFGPCSLEIKQFLECAQNQSDVKLCEGFNEVLRQCRIANVDHPRPVDHGERNVKRRKYNEGFLQYGFTSTITVGIERPQCVICGVVLSAESMKPNKLKRHFESKHSSFAGKDTNYFRSKADGLKKARPDTGSKSNKQNVAAVETSYLVALRIARDMKPHTFAEHLLFPVAKDRVRVMIGDEFVTKLSAVSLSNDTVRRRIHDMSADILDQVVQEIKSAPLPICSIQLDESTDVANCLQLMVYVRYINDGDFKDEFLCCKPLERTATALDVFEAVDSFLRQHEISWKSICGVCTDGAPATLGCQSGFQRLVLNESPKAIGAHCMLHLQTLAMKTLPQDFQEVMKSVLSSVNFVKASSLNSRLFLQLCSDLDEPSKTLLLHTEGRWLSRGKVLKRIFELRDELKMFFNQKAIRQFEALFSDNSALQKVAYLVDIFTILNELNLSLQGPNSTCLDLSEKIHSFQMKLQLWQKKLDENKFYMLPTLSAFFEEHDIEQHKRITVVISVKEHLDMLASEISWYFPNLPEIPFALARSPFSVKAEDVPETAQEDFTRLTNSDAARADFSTMPVTQFWVKCLQSYPVLSEMVLRLLLPFPTTYLCETGFSSLLVIKSKYRSRLVVEDDLRCALAKTTPRISDLVRKKQSQPSH
Protein: Zinc finger protein 10 (AtZFP10) (O80942)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that may regulate cell division and growth.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SLB8}.
Interaction partners:
- Zinc finger protein 6
- Zinc finger protein 3
Sequence:
MEKPGGFWIPKKSNKESSWEELAFAEDDAAGSLWPPRSYTCSFCRREFKSAQALGGHMNVHRRDRARLKQADDQYLFPKSSSSPEYPSHKDSDNIHETSCYTLVFNTKPNYFKTQHSCVIDLSSSSSLPYLTPSRVSSGLPGKQHTSSSPPSFVVEPSKNSKYIPSSSPWSCPSTVVEQKSCDLYEIPAMEGEKKRKTESDVPKIGHKAKLSLGNTTDLSVSMNLVIHQSFPITAHGSDEEIGRVDIRKRRRRHESPSQQSIFISSLSCKSDIITRNEESKHKGDRFEDLDLELRLGTDPPKGI
Protein: Elongator complex protein 1 (A0A0R4IJ07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR017233}. Nucleus {ECO:0000256|PIRNR:PIRNR017233}.
Interaction partners:
- Elongator complex protein 5
- Elongator complex protein 3
- Elongator complex protein 4
- Elongator complex protein 2
- Elongator complex protein 6
- Cytoplasmic tRNA 2-thiolation protein 1
- Protein KTI12 homolog
- Adenylyltransferase and sulfurtransferase MOCS3
- Ubiquitin-related modifier 1
- Diphthamide biosynthesis protein 3
Sequence:
MRNLSLLKRFRSVDLPIPGSPQCFSIRSEAGTVLVASEFAITEYNPQTGEVLNEVSLTADDYLPEDGSGIVLAIQDLPDQESVCLATANGDVILYNLNTSQLECVGSVDSGLTGMTWSPDQELVTLTTGQESIIMMTKDFEPITEVAINQDDFGEDKFITVGWGKKETQFHGSEGKQAAQRKAAEVQPALPWDDRKPRITWRGDGQFFAVSAVCPQTGARKVRIWNRECVLQTTSEVVNGLEQSLCWKPTGSLIASTQRHPNKHTVVFMEKNGLLHGDFTLPFEKDQVKVKELLWNSDSTVLAVWAEDLKPKKNDHPNTYIQLWTVSNYHWYLKQSLHFGKDPIKAPACVCWDPEKALRLHILTSGLVSCTYDWGWSTQRSHGLDCHDNANVAVIDGDKVLVTTFRQCVIPPPMCAFELQLPVPVNLVTFHSQAQRTNELAALTADGQVHVYSEGGGTENKAASAFKVVSAPLVLKKTYRVNVDQEEPLTLRLLLWLSEDMFLAVAHGRSMTRLLKLTPSDNQDRKDMMEIGSDIEVDGHVISLCHSLKNGTVALQLEDGQIQKLLMDSSGPSVTEWKDSTGNTINFPQPCVQMALCTLSEEEYFIGLTERSHLFIGDSLVASNISSFVVYDEFLLLTTHSHMCHCLRLSMLSVKGIQSALSSDANQNDETVRKVERGSRIVTVVPQDTRLILQMPRGNLETIHHRALVLAQLRKWLDGLRFRDAFECMRKLRINLNLIYDHNPTVFLDNIEIFLKQIDSINHINLFLTELKEEDTTTTMYPCPSHSAVGKEGKKVDVVCDALRSTMETLDPQKYCLCILTSHVRKTTPELETALQKVHELRVNPPGGTSSVSAEEALKYLLFLVNVNELYEHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNMLKTLEPNYQRYTIDKHLKRYRKALHHLSKCGEEHFTEMLNLVKDQRLYSDALELYPSGSQQYKTLSVAYAEYLVEQQQAEQAGLLLWRCGESTRALQAFVSCTSWRNALAVAAQIPLPPQQLALLARDLAEKLLEARRHTEAALCLEQYAKDCEEAISALIQGAAWEEALRLIYLYNRQDIIETDLKPALLEAHSNQTSFLESQKALFIRHKNRLSVVRELKAKASLELFGEDGPDCADAELYSEASSVMTGSHLGSKYSRSNSRISSRSSKNRRKAEGKKHSLKEGSPFEDIALLNALTQIITVVDKMREEVHSLLKALVLFQFDDAASALQRDYSDLLLLMDKSIPDIWSENLQPGQNTLTGPNSTVNSIVASFQQQKPAVPQQDTEALAPPKMRNSVKWKLNILK
Protein: Zinc finger protein 775 (Q96BV0)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MESGLAGNGTGAGLVMKVKQEKPERLLQTLAPQAMLVEKDKENIFQQHRGLPPRQTMGRPRALGGQEESGSPRWAPPTEQDAGLAGRAPGSASGPLSPSLSSGEGHFVCLDCGKRFSWWSSLKIHQRTHTGEKPYLCGKCGKSFSQKPNLARHQRHHTGERPFCCPECARRFSQKQHLLKHQKTHSRPATHSCPECERCFRHQVGLRIHQRAHARDRQGSRAGLHELIQDAAARRACRLQPGPPRGRPEWAWLGLCQGWWGQPGARAAVSGPEGPGEPRQFICNECGKSFTWWSSLNIHQRIHTGERPYACPECGRRFSQKPNLTRHLRNHTGERPHPCPHCGRGFRQKQHLLKHLRTHLPGAQAAPCPSCGKSCRSRAALRAHQRAHAVAEPAVPAGEPGDQPQAEAIPGLAARPRSSQRSPGARDTLWGRGQAGLAGPGEPRQFICNECGKSFSWWSALTIHQRIHTGERPYPCPECGRRFSQKPNLTRHRRNHTGERPYLCPACGRGFSQKQHLLKHQRVHRAAPACSPKEEAR
Protein: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (O70343)
Organism: Mus musculus (Mouse)
Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
Subcellular location: Nucleus {ECO:0000269|PubMed:22886304, ECO:0000269|PubMed:23217713}. Nucleus, PML body {ECO:0000269|PubMed:22886304}.
Interaction partners:
- Peroxisome proliferator-activated receptor alpha
- Forkhead box protein O1
- Nuclear respiratory factor 1
- NAD-dependent protein deacetylase sirtuin-1
- Steroid hormone receptor ERR1
- Peroxisome proliferator-activated receptor gamma
- Hepatocyte nuclear factor 4-alpha
- Transcriptional repressor protein YY1
- Cyclic AMP-responsive element-binding protein 1
- Nuclear factor erythroid 2-related factor 2
Sequence:
MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGAVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSGLSRGHEERKTKRPSLRLFGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSGQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKTSELRDGDFSNEQFSKLPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
Protein: Ataxin-10 homolog (Meiotically up-regulated gene 160 protein) (Q09888)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Transcriptional regulatory protein moc3
- 10 kDa heat shock protein, mitochondrial
- Vitamin H transporter 1
Sequence:
MEKMESTEEWEALLSSSSNGDELTMKLIRNGLAKGFKSQKAAGDAGLYSRFLPYHFTESVSNDSFSSLPWQIFANSVAGNSPLQNEAWAFLMDNEDFFLPVPMNPAQCTALEIALWSLIRVDDQRLFELCHSKSGIRLLSIIFDFDSHPDWLREDVMFNIAERILKSNFPNVLVNVASKIGPKSIYFLIDCMSHKIKLKETATGFYVILDVLSCVGRQFASVLEECFTKEISSAGLDHINHFSEIVMLGVDLLYRDYVSYDTTISLKNDDSSSLGDMEFETSQPSSSISEIIHLLAVLDKRIPKKTLVEKTYASSMELQELYNAVVGVKRECVRFIAFICSKFSTAPDLVRHFNGVALIISQANYDDWNPYIREISVLCTRLLLQNNIENQKIIGGLTPITTTHSDALEEAGFTSYINDKGKVVLQPKTAKNSH
Protein: Uncharacterized protein C18B11.08c (Q09714)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Eukaryotic translation initiation factor 1A
- Small ribosomal subunit protein uS3
- UPF0674 endoplasmic reticulum membrane protein C2G5.01
- Probable eukaryotic translation initiation factor 2 subunit beta
- Small ribosomal subunit protein uS10
- Eukaryotic translation initiation factor 2 subunit alpha
- Probable eukaryotic translation initiation factor 5
- Telobox protein 1
- Eukaryotic translation initiation factor 3 subunit C
- Small ribosomal subunit protein uS14
Sequence:
MAPAELKRPDLIVPYKARVKANEEVGLSLVSTATCMAALFLRFKLIAWVAFILTFSNLLNANTSPSSSPTSMAFMGIAALVSTYLPQFLNTPNKT
Protein: Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (P85045)
Organism: Bufo gargarizans andrewsi (Andrew's toad) (Bufo andrewsi)
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has antibacterial activity against the Gram-positive bacterium S.aureus and against the Gram-negative bacterium E.coli with a MIC of 1 uM and 8 uM respectively. No antifungal activity against C.albicans.
Subcellular location: Secreted {ECO:0000269|PubMed:16309969}.
Interaction partners:
Sequence:
SGKYISWEDSCSYLQLQKYERCELAKALKKGGLADFKGYSLENWICTAFHESGYNTASTNYNPPDKSTDYGIFQINSRWWCNDYKTPRSKNTCNIDCKVLLGDDISPAIKCAKRVVSDPNGMGAWVAWKKYCKGKNLSQWTQGCKL
Protein: Regulator of G-protein signaling 2 (Q99188)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase activating protein for GPA2. Negatively down-regulates glucose-induced cAMP signaling via GPA2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Guanine nucleotide-binding protein alpha-2 subunit
- Bud site selection protein RAX1
- Guanine nucleotide-binding protein alpha-1 subunit
- Protein SST2
- Structural protein MDM1
- Guanine nucleotide-binding protein subunit beta
- G protein-coupled receptor GPR1
- Chitin synthase export chaperone
Sequence:
MASVPSLCDILIPLEKNSRSDGDAESSNTVLIQLRKGHHERMRSPYTIQKFYKFLKRAHCEENLEFFEKAHQFLQLKQNRSISEEKLLEVWNKSLYIKYIAVDSPKECNFSQDTREIFEKCFANNEVPADVDVLCAISHVMGLLMDGYHRFVSSVNEKKYSATYAHNDSATEQDLKNESTTSFSSLGVEDISEDRNSYLKKPDINGLSTIIQETSANTTNESQCSDRTSRPSESSSSLNTTSSTYKNTSTRNLQKPQNTGILNSGKGLLQKLNFVKKRKSFKQPSGVICSHYNSNVQNRLKGQNSHQQR
Protein: GATA-type domain-containing protein (Q9XUW7)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- GATA-type domain-containing protein
- GATA-type domain-containing protein
- Probable transcription factor elt-4
- Transcription factor elt-1
- T-box transcription factor tbx-35
- Transcription factor elt-6
- Protein pop-1
- Defective pharyngeal development protein 4
- Protein skinhead-1
- T-box protein 37
Sequence:
MYSNSFSSSSSSSNSPMSFDFGFPQFPEQVQFNEEGYGTPSPDVLQNMNYHHYPAQDMTTNSYNGGYDNSMQQNFMQPDNGAGYYNENYQQMPDFQFPVQNFDFTNQFEFTTPINDLQQSQTSINHTNPDNNENSMPEIPIDGGFNFFPAQEVQEWKPARKASKNKIKKISTMHINSSCSNCGCRETKLWRRNEQGETECNPCNLYERVKGHKRPQHLWNKPAAKRRRRPVAPLVDSNAFNF
Protein: Guanylyl cyclase-activating protein 2 (Guanylate cyclase activator 1B) (D3ZID7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Retinal guanylyl cyclase 1
- Guanylate cyclase 2D
- Retinal guanylyl cyclase 2
- Guanylyl cyclase-activating protein 1
- Cyclic nucleotide-gated channel alpha-1
- Cyclic nucleotide-gated channel subunit beta 1.
Sequence:
MGQQFSWEEAEASGEMDVAELQEWYKKFVVECPSGTLFMHEFKRFFKVTGNEEATQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDRNGCIDRLELLDIVEAIYKLKKACRAELDLEQQGQLLTPEEVVDRIFLLVDENGDGQLSLTEFIEGARRDKWVMKMLQMDVNPGGWITQQRRRSAMF
Protein: Transmembrane protein (Q9LW52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein AT3g24100
- Glycine-rich protein
- Protein SMAX1-LIKE 5
- Metacaspase-9
Sequence:
MGRLVSGATLLALLCFHVFVVNVVARDVSSGRDEDEKTLVGGGKGGGFGGGFGGGAGGGVGGGAGGGFGGGAGGGFGGGGGGGGGGGGGGGGGFGGGGGFGGGHGGGVGGGVGGGHGGGVGGGFGKGGGIGGGIGKGGGVGGGIGKGGGIGGGIGKGGGVGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGVGGGFGKGGGVGGGIGKGGGVGGGFGKGGGVGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGIGKGGGIGGGGGFGKGGGIGGGIGKGGGIGGGGGFGKGGGIGGGIGKGGGIGGGFGKGGGIGGGIGGGGGFGGGGGFGKGGGIGGGIGKGGGFGGGGGFGKGGGIGGGGGFGKGGGFGGGGFGGGGGGGGGGGGGIGHH
Protein: Uncharacterized aminotransferase C27F1.05c (EC 2.6.1.-) (Q10174)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Protein arg11
- Uncharacterized membrane protein C27F1.10
- Argininosuccinate synthase
- Arginine biosynthesis bifunctional protein ArgJ
- Arginase
- Ornithine carbamoyltransferase, mitochondrial
- Arginase
- Amino-acid acetyltransferase, mitochondrial
- Argininosuccinate lyase
- Probable argininosuccinate lyase
Sequence:
MIDSTSTATATSKTVELNTNGSKTDASSENGTASNYPEGLWCFDEAMKMDPETTVKLQLDHLNKLRTVHGHARNFVKADNSRFVDEKGTEHLDLIGGVGVVTVGNNNQYVWDCLQKCFDAKLYMMGAISYRNLAAAFGRNMALLSPGQKLTRTWTATGGAEANEGVIKLIRLATRYKPNKKKFLSTLNSFHGKTTGAVFLGGKEKWQKYQSPAPFDVDYVPYGDAEALQVALSSGMYRSFIVEPIQGEGGVIVPPPGYLAKARELCTKYDTYLVLDEIQTGCGRTGKFWACEYENIIPDCIAFAKGFSGGLIPFAGYIATEELWNAAYNSLETAFLHTATYQENTLGLAAGVATIDYIVQNDLLSRCRKLGGIMFDRLNKLQTKFPHVMKDVRGRGMIVGIEFYPIPESVQEEFGEYYATPIVNDLADTYHVQVYCSLNNPSVFRFLPPLTIPEADLDEGLSAVESAVAKFDAKVKEAVAAKST
Protein: Bifunctional transcriptional activator/DNA repair enzyme Ada (Regulatory protein of adaptive response) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (O6-methylguanine-DNA alkyltransferase)] (P06134)
Organism: Escherichia coli (strain K12)
Function: Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demethylate the other diastereomer, Rp-methylphosphotriester. This is a suicide reaction: the enzyme is irreversibly inactivated.
Interaction partners:
- Alpha-ketoglutarate-dependent dioxygenase AlkB
- DNA-3-methyladenine glycosylase 2
- ABC transporter ATP-binding/permease protein YojI
- RNA polymerase sigma factor RpoD
Sequence:
MKKATCLTDDQRWQSVLARDPNADGEFVFAVRTTGIFCRPSCRARHALRENVSFYANASEALAAGFRPCKRCQPEKANAQQHRLDKITHACRLLEQETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLRESLAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFRHGGENLAVRYALADCELGRCLVAESERGICAILLGDDDATLISELQQMFPAADNAPADLMFQQHVREVIASLNQRDTPLTLPLDIRGTAFQQQVWQALRTIPCGETVSYQQLANAIGKPKAVRAVASACAANKLAIIIPCHRVVRGDGTLSGYRWGVSRKAQLLRREAENEER
Protein: Serine palmitoyltransferase 1 (SPT 1) (SPT1) (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (P25045)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
Subcellular location: Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Serine palmitoyltransferase-regulating protein TSC3
- Protein ORM1
- Protein ORM2
- Serine palmitoyltransferase 2
- 3-ketodihydrosphingosine reductase TSC10
- Phosphatidylinositol-3-phosphatase SAC1
- Serine/threonine-protein kinase TOR2
- Serine/threonine-protein kinase TOR1
- Inositol phosphosphingolipids phospholipase C
- Target of rapamycin complex subunit LST8
Sequence:
MAHIPEVLPKSIPIPAFIVTTSSYLWYYFNLVLTQIPGGQFIVSYIKKSHHDDPYRTTVEIGLILYGIIYYLSKPQQKKSLQAQKPNLSPQEIDALIEDWEPEPLVDPSATDEQSWRVAKTPVTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLSATEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSVLYGQDFCAAPSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTVYYFNHNDMNSLECLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKLKNKYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALGSTGGFVLGDSVMCLHQRIGSNAYCFSACLPAYTVTSVSKVLKLMDSNNDAVQTLQKLSKSLHDSFASDDSLRSYVIVTSSPVSAVLHLQLTPAYRSRKFGYTCEQLFETMSALQKKSQTNKFIEPYEEEEKFLQSIVDHALINYNVLITRNTIVLKQETLPIVPSLKICCNAAMSPEELKNACESVKQSILACCQESNK
Protein: LD31448p (Q9VHC8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- ATP-dependent RNA helicase WM6
- LD24793p
- Hpr1
- THO complex protein 7
- FI07663p
- THO complex subunit 5
- THO complex subunit 6
- THO complex subunit 2
- RE74585p
- Eukaryotic initiation factor 4A-III
Sequence:
MPESDVTKMKVADLKRELKLRGLAVNGNKTELQDRLQTALLEGDLSLEDSAIADAIDDDDVSFTDEDEHKLLGDENDDELLKSPVSTPTTVAIPDLLAEEKTSSAPDAAAPTKKIVLKRNNSQQSTGTVASTGTTPSKENEAPAAAASDSTGETPTKKHKPIVVGPKTEGEKPSGDKKLNQLTAQERLELRAKKFGITPPAVANTATAVAVAINKSSSASITANKGNKETEEQQKEALKKRAERFGFVVPDKAPTSKADDRLQKRKERFGAGAVSAATTTPTTTESKDAWSEKARARLERFKTAPSTN