wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor like protein kinase S.2 (LecRK-S.2) (EC 2.7.11.1) (O48837)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Extracellular ligand-gated ion channel protein
- At1g13195
- AT5g37540/mpa22_p_70
- Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC
- AT4g33900 family protein)
- 1,4-dihydroxy-2-naphthoyl-CoA thioesterase 1
- Duplicated homeodomain-like superfamily protein
- VQ motif-containing protein
- Phosphate transporter PHO1 homolog 5
- GDSL esterase/lipase At4g10955
Sequence:
MAPMAMDHLCFVLPTESGELKPPVMVEETTEEEEEKKSRDCGRQVVSLIGDLFRRLHGSKLVKSLNLCSINESKDSISMEINKSFTDMEGVQLSSKVGCENPRIFGYSELYIGTNGFSDELILGSGGFGRVYKALLPSDGTTVAVKCLAEKKGEQFEKTFAAELVAVAQLRHRNLVKLRGWCLHEDELLLVYDYMPNRSLDRVLFRRPEVNSDFKPLDWDRRGKIVKGLAAALFYLHEQLETQIIHRDVKTSNVMLDSEFNAKLGDFGLARWLEHKIDETEHDSSYDSVSSFRNHQFRVADSTRIGGTIGYLPPESFRKKTVATAKTDVFSFGVVVLEVVSGRRAVDLSFSEDKIILLDWVRRLSDNRKLLDAGDSRLAKGSYDLSDMKRMIHLALLCSLNNPTHRPNMKWVIGALSGEFSGNLPALPSFKSHPLYIPLSSLKSTSTSATTTTTRTTMTTTTSTTSFNASSESTPSSNYVTALEDSIYQTAETGENPYFNYNSRRVMSSKSFVLDTPREISYNDLVLATDNFSDARRVAEVDFGTAYYGLLNGDQHIVVKRLGMTKCPALVTRFSTELLNLGRLRHRNLVMLRGWCTEHGEMLVVYDYSANRKLSHLLFHNHIPGNSVLRWKSRYNVIKSLACAVRYLHEEWDEQVIHRNITSSTIFLDRDMNPRLCGFALAEFLSRNDKAHQAAKKKGSAQGIFGYMAPEYMESGEATTMADVYSFGVVVLEMVTGQPAVDYKRKKEDALMVLRIREVVGNRKKLLEEIADIHLDDEYENRELARLLRLGLVCTRTDPKLRPSISQVVSILDGSERFFEEEGGKEGDVSRKQMYDSSMLMIRQMQALGIH
Protein: Homeobox protein engrailed-2 (Gg-En-2) (Homeobox protein en-2) (Q05917)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus.
Interaction partners:
- Paired-box containing protein Pax-2
- Protein Wnt-1
- Fibroblast growth factor 8
- Paired box 5
Sequence:
MEEGGRSPREEAAEPQESGGDAEPGGGRRALLLPPGDPPHPHPHPHRITNFFIDNILRPEFGRRKEAGGTAGEPRRPGAESRRSPAAAAPAPGAPVPGGGGGGGGGSPGRGEGGPAALALHGAAKKGGDPAALEAALKARGLSGAELSVSSDSDSSQAGSNAGNQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIWFQNKRAKIKKATGSKNSLAVHLMAQGLYNHSTTAKDGKSDSE
Protein: Leucine-rich repeat protein (LRRP), putative (Q9N949)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKVRITDHNTFWHAPQLLPYNTSPPRLIHRLALLLKKKKHFLNTQHLKESETGTTMSGNQGRKRQRSSSPEQSEALKEPSTTEQNKLTTVTITEETRDAGNDETVISLLNEHEKLIKQTTRLESSVKALKCFMSNLTAMSGERQGGVCDDTECIHRVTLYNAADNAFSDEGLYEGALSSLCGRIQAKKLTITLSKGWKFNSRQVSKLKQLEELRIEYPRGKLVNMISLKRLQMLKRLCLRSNNIDNNDGRHLFNIGTLEELAITDTMQLTNIRGISRLTNLKCLELNSTNIDDSCVEEISACAKLSKLCISKCNNITDATPISQLAALEELNLSNCHITKGIGTLGMLLRLRMLDLSGVPVEDNCLKDLCDCGSLERLNISYRIQLTDINPLSNATAIEELNLNGCRRITRGIGVVWALPKLRVLHMKDVHLSEPSLDSVGTGGPLVKVSLDNCAGFGDMTLLSSIVTLEELNIQKCADIISGVGCLGTLPYLRVLNIKEAHISSLDFTGIGASKSLLQLNMESITGLSNVEALANILTLEKLSLHGCTGIDAGIGCLGNLPQLKMLDLSGTNTDNESLRSLCLSQTVVSLNLSHCWKMTNVSHISSLEALNELNLSNCFGINAGWEALEKLQQLHVAILSNTHITDRDISHFSNCKNLITLDLSFCNKLLDVTALSNITTLEELNLDSCSNIRKGLSVLGELPRLCVLNIKGVQLEDSVIVSLGNGNSFVRLSLENCKGFGDVAPLSNLVTLEELNLHYCDKVTSGMGTLGRLPQLRVLDLGRTQVDDNSLENICTCSSPLVSLNLSNCKKITSISAIASLTALEELNIDNCCNVTSGWNVFGTLHQLRVATLSNTRTNDENVRHVSECKSLNTLNLAFCKDITDVTALSKITMLEELNLDCCHNIRKGIETLGTLPKARILSMKECYMGDGYAQQCSILGNSKSLVKLNLERSRGRISVKALSNVATLEELVLDHARKVCCIPSFSCLPRLRVLNLKYTDINGDVTKNISESKSLRSLNLSHCKWVTDISVLSSLLTLEELNVNCCNGIRKGWESLGKLPLLRVAILSDTKITAKDIACLSSCKKLVKLKFFQCEKLSDVTVVYKIQSLEELIVTSCSDGLKGLNALGTLPRLRFHHLRNVRGSDISVESIGTSKSLVRLHIEVGEELTDITPLSNITSLEELSLRDYRKPPEGVGTLGKLPRLKSLDLGLSRISDSTLYCICLSRSITSLNLDSSWKLTDISHISNLTALEELNLGGCYYITSGWEALSELPRLRVLNLEFTRATTRDGGYYISRCKYLVTLNLELCDMTDASCLANIKTLEELHIGGCDELTQGFSALFTLPQLRILNLICSLITDEDLREIQPPHTIEELNLSYCVELNDITPLGRIKSIKKLHLRQRHDVRRPTEGFRSLLELPCLSWVDLDNVYGWSDVSCELRKRRVHIR
Protein: Chromo domain-containing protein cec-3 (Epigenetic memory antagonism protein 1) (P45968)
Organism: Caenorhabditis elegans
Function: Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc-4 is expressed in the vulval but not in the non-vulval VC neurons.
Subcellular location: Chromosome {ECO:0000269|PubMed:24685137}. Nucleus {ECO:0000269|PubMed:24685137}. Note=Colocalizes with H3K9me2/H3K9me3 in germline nuclei. {ECO:0000269|PubMed:24685137}.
Interaction partners:
- Chromo domain-containing protein
- Histone-lysine N-methyltransferase set-25
- Protein lin-61
- Lysine-specific histone demethylase 1
- Chromo domain-containing protein cec-4
- Chromo domain-containing protein cec-1
- Lysine-specific demethylase 4
- Chromo domain-containing protein
- Chromobox protein homolog hpl-1
Sequence:
MSNEGSREESREPEAREGKSDEIFEVEKILAHKVTDNLLVLQVRWLGYGADEDTWEPEEDLQECASEVVAEYYKKLKVTDKTELIELLQKQIKKNKSQKSKKRSKTVSDHESNHDSDGSYGTPKTSKKSKKSAKNETPVSSKVPKVPTKAALKSYEATVSGPVAPNNAKKAAMEVRDTRRNWLDEESSDDEAETTAPLSDVEKIASKVKVVKAVEEKAEEPVKRPSTPPKPREVVIKKDPSESPVASASSVIPTSKRKSINAETSNGRQRTLAPPVIVKDETTWTVDGIARHTDVDNTKTKLILMTNSATGERKVVEGREAFELDGWALAKYLLDRCEF
Protein: Cbl proto-oncogene like 1 (C9K074)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRML
Protein: Uncharacterized protein (Q389Y7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVSFFVQEVRSNPAVDAETAAVTSLNTLFHKSGLYLSTASTQLHVTPEAVCVIDAQDLYAIARYAHILVTNRDVQCDFSALSSVLWNQVKNVGDRIDVYLHLLESAGHARQSRAALDLQPLHLTLLTHALYILRQIEEPHARQEVRDAVSIVQKDVEMVVRLGKKLLHVLGDALDKSGVADNRFLLAAEMALCAAEMFAASIASRSAIDVSPLITFFNSEASWRLSGISIEATGSYCGALHRLIRTLFARQNDFDGVERVTAKLLVNRLTTRPPFDWEMFKRIHPPHKGTVTPQYIVLCNMSTVQLCIRKLLLQNHSYVSALKKNCIRLLQEMSSRKEMLSFYQVPLLAALQGMPEFDLSDDAQLQLRAVETHLGNNEQIMQPNFLRILMAYGYTVPHEQHNPLTRGSVLSLFRAVTEQLFQLPMIQSGNVNKMTHTLLQPPVPTLSFIRLVVEASSNDVETASEVLAEMMKVLTTMYEASVAQCELYQTPVRVSKPLRRVLALTMTLLFEFFRFPSFVKAVNHITALEALARIYAIARLYVTAESNATETERKSAMRLLVRMAAKLVVVSESMKVPEVNTFFVDSLLPLSSMESLTHRNHQQYALLEAYLRAFASGAVVTVMEEETLLKHWVDVSLRCITNRLSGALAVAGLTFLSAVFLSKRAVAPLFVPTYVELMVPTSQPSRYGEPPLYLTRRFAKTVRACCQALEGCDERALEEIIHDQNSSVAKVVRDMFGNDKNLSLLENIRPISSILLVVSSLFDKVCALLGNTAGPALATTQDRLARFQVYYSALINLLQCRSTAVLHRVCASVEAVMLEQLRGVPSVQAQWIKHIGNIVDSLQGIGKTAVAEWFLVLSERTKKMIPHARL
Protein: Protein nervous wreck (Nwk) (X2JAU8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation. Required for normal structure and function of synapses at the neuromuscular junction. Plays a role in synaptic vesicle trafficking. Required for the release of a normal number of synaptic vesicles per action potential.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:14980202, ECO:0000269|PubMed:21464232, ECO:0000269|PubMed:26686642, ECO:0000269|PubMed:29568072}. Synapse {ECO:0000269|PubMed:29568072}. Cell projection, axon {ECO:0000269|PubMed:14980202, ECO:0000269|PubMed:18701694, ECO:0000269|PubMed:26567222, ECO:0000269|PubMed:26686642, ECO:0000269|PubMed:27601635}. Presynaptic cell membrane {ECO:0000269|PubMed:26567222}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:29568072}. Recycling endosome {ECO:0000269|PubMed:21464232}. Note=Detected at presynaptic axon terminals at the neuromuscular junction (PubMed:14980202, PubMed:18701694, PubMed:21464232, PubMed:26567222, PubMed:26686642, PubMed:27601635, PubMed:29568072). Colocalizes with Cdc42 and Rab11 (PubMed:18701694, PubMed:21464232). {ECO:0000269|PubMed:14980202, ECO:0000269|PubMed:18701694, ECO:0000269|PubMed:21464232, ECO:0000269|PubMed:26567222, ECO:0000269|PubMed:26686642, ECO:0000269|PubMed:27601635, ECO:0000269|PubMed:29568072}.
Interaction partners:
- RE12101p
- Dynamin
- SD19533p
- Dynamin associated protein 160, isoform D
- receptor protein serine/threonine kinase
- WHAMM and JMY related, isoform B
- AT02057p
- Amphiphysin
- Cdc42-interacting protein 4, isoform B
Sequence:
MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDESPPPTAAPTFALPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSDDGQPPPSLPPPQLAKAGGSAPGSGSKVEKGAAAGGANTLNLGMAQIIVTAATPMVEDGADKSFPPVGESDAQPVEPVSKEQPAEVAKKPDIAPKPLAKVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSASVADVPVLQDAEDPFNEKAKGESGDGSGFEANFEANFDANFDDAFAGIGGGGGGGGGGGEQSNELDINGEAAGEAIVSGSAAGDEDIEAPKQVVGGRASIPEELDSNQLAHYHEHEIYYVDYSHGQL
Protein: Elongation factor Tu, chloroplastic (EF-Tu) (Ras-related protein RABE1b) (AtRABE1b) (Ras-related protein Rab8D) (AtRab8D) (P17745)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase EFR
- Elongation factor Ts, mitochondrial
- Polyprotein of EF-Ts, chloroplastic
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL31c
- Large ribosomal subunit protein bL21c
- Large ribosomal subunit protein bL36c
- Large ribosomal subunit protein bL21m
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
Sequence:
MAISAPAACSSSSRILCSYSSPSPSLCPAISTSGKLKTLTLSSSFLPSYSLTTTSASQSTRRSFTVRAARGKFERKKPHVNIGTIGHVDHGKTTLTAALTMALASIGSSVAKKYDEIDAAPEERARGITINTATVEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSGADGPMPQTKEHILLAKQVGVPDMVVFLNKEDQVDDAELLELVELEVRELLSSYEFNGDDIPIISGSALLAVETLTENPKVKRGDNKWVDKIYELMDAVDDYIPIPQRQTELPFLLAVEDVFSITGRGTVATGRVERGTVKVGETVDLVGLRETRSYTVTGVEMFQKILDEALAGDNVGLLLRGIQKADIQRGMVLAKPGSITPHTKFEAIIYVLKKEEGGRHSPFFAGYRPQFYMRTTDVTGKVTKIMNDKDEESKMVMPGDRVKIVVELIVPVACEQGMRFAIREGGKTVGAGVIGTILE
Protein: Cyclin-dependent kinase 5 homolog (EC 2.7.11.22) (Cell division protein kinase 5) (P48609)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development (By similarity).
Interaction partners:
- Cyclin-dependent kinase 5 activator
- Microtubule-associated protein
- Cyclin D, isoform D
- Cyclin G
- Presenilin homolog
- dihydropyrimidinase
- G1/S-specific cyclin-E
- P53, isoform B
- Cyclin-G-associated kinase
- Uncharacterized protein, isoform C
Sequence:
MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDSSSSGH
Protein: BEN domain-containing protein 2 (Q8NDZ0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:31429579}.
Interaction partners:
Sequence:
MSERTQEQDFVIITVDDSDDNNDCSIEMVEVSETADNSTNDIADDSTYVTADNPTDDTATQPNFPGGNDGHHRPLQMSYGSGSVTQAGVQWHDHSSLQPQPLGLKQFFHLSLPSSWDDRRTPPCPVAHGDQIVSQINHPVHLRRYSYNSEEVDFPKRGRFYTPEVQSSISPPAERQETHAWASPAVTSLESAACHELQEADLSESLSYPRIVSSSSLQQYVAQGGSFPCFGMPWNFISGGAESTNAVISFANATTAVPMAVLSRRESSLANNPGVVNYSALPENENVGPGRALSSFCFHPNLEMPERPANSSKNSTETANYPTLMGNYNGQNTASLSVFIPPYFAEKIILTEMPGTTETNVENNSQTVYYPALSGNTSAPYPASSYLPITSNFESGPQMSYGTMSYSTEMKNNCDQDDASASACLTPDFALLPLNILVKVDTNTENSVNTMNRSTLLDSDSGQDSSSSSVCIPPKYGYLGDPKRNVRVLKIHLLAVQNMAKPKQAACYLVRILFSKEILISSSVDIHLKDSQSLDPNKMAALREYLATTFPTCDLHEHGKDWQDCISGINSMIYCLCSEGKSTPKTVRKNKKRTNRVASASADRNDQRGRDGGEGCSWMFQPMNNSKMREKRNLQPNSNAIPEGMREPSTDNPEEPGEAWSYFGRPWRNIRMPCSVLTLAKTKSCASLSARYLIQKLFTKDVLVQSNVYGNLKHGLCALDPNKISALREFLQENYPICDLSENGRDWKSCVTSINSGIRSLRHDVRRAEARSQSLPAVTPPELEQESKPGDPDATDPST
Protein: ADP-ribosylation factor 6 (Q9Y7Z2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTP-binding protein that functions as a molecular switch for the activation of 'new end take off' (NETO), a process in which the directions of cell growth change from a monopolar manner to a bipolar manner in fission yeast. Involved in supplying membrane to the growing new end.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18060866}; Peripheral membrane protein {ECO:0000269|PubMed:18060866}. Note=Localizes at both cell ends and to the cell division site in a cell-cycle dependent manner. {ECO:0000269|PubMed:18060866}.
Interaction partners:
- PH and SEC7 domain-containing protein C11E3.11c
- ADP-ribosylation factor 1
- Uncharacterized protein C211.03
- Guanine nucleotide exchange factor MSS4 homolog
- UBA domain-containing protein 3
- Actin
- Probable Rho-type GTPase-activating protein 4
- Probable Rho-type GTPase-activating protein 3
- GTPase-activating protein gyp3
- Cell division control protein 42 homolog
Sequence:
MGNSLFKGFSKPFSRLFSNKEMRILMLGLDAAGKTTILYKLKLNQSVVTIPTVGFNVETVTYKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMRDCLLLVLANKQDLPGALSPAQITDVLQLDKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAKLK
Protein: Probable WRKY transcription factor protein 1 (WRKY domain-containing protein 1) (Q554C5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SI37}.
Interaction partners:
Sequence:
MGAQYSTELNKYNNNNNNNNNNNNNNNNNNNNHTISGNENLNNNNNNNNNNNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNGNSNSNSNNNNNNNGINKYSNYFESLINNTNKDTNIPNNSNSNNNNSDRDFIQNMIKSANQIKPGEKELVLFHKLHQSLKENQSFSIEELRNSSILSISPDKSFLTNINEINVNNNNNNNNNNNENNKVGVNGSSTTTTTTTTTTTNNNSNNNNNNNNNNNNNNNNNNNNNEDDEDDYGDDDTIENNEPTFVDKPNKSAKLQKPKLKSNLNDTNGGNSPQQNGKISKYMAKKLLALQQKQLEQEQEQKQQQKQQQQQQQQQQQQQQQQQQQQQKDAIENINNNNNNKLQPIVKNSVNKTTKQKKNKTTTHNVKQQITFLTKSDNEDEYDASDEYIDDDDDDDEKYDDDDDEYFEGNNNNNYKKNNISNKSKNKNNNDESDSFSESEIFKQKKLNHDKNQSNPKQQLTSHSEFDNSLLNKNQSRTNSKIQKLQIKEENYHQIQQEHGEKQQQQQQQQQQPQQQQQQQQQQQQQQQQEMQVDKEQTEKIINTNKKEEQKPNDYFPPIPTNPFKRDNETAFGKNNENNNNNNNNNNNNNNNNNNNNNNNNNNYRNNKPNGEGFLSNLKIIPPMISSSPYYSKKSSNVVPTSPKSNLSDQQPPFSPVQISPQKQSPATTTTTTTTTTPTPLKKQKKNKTNNNINNNNINNNNNNNNNNNNNNNNNNNNNNNNNNYSINNINNEEDEENNSTQNNNNNNNNNNNSPQNSNTNSNNSNNSNNSNNISNIVSDGYQWRKYGQKNVKGSLHPRHYYKCTFQGCNVRKQVERIGDTNQNSTVYKGEHCHGFPQTTRVVSDQQAFRNSVMFEGLDGNNNNNNNNNNNNNNYSSNSNSNGNGNGNGNGNGNGNGNGNGNSNGNQDQNGNSFNDQNGDSPTQHGQISPMNSPKNTIPTTTTTTTSISTYVNTNSTNKKNNSKQEKKISVKNETTDDDEFQEDIDQLSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDDNNNNNNNNNNNNNNNRFNGTSESKGSKKLVIETGSSIDHLDDGFFWRKYGQKSVKGSPFPKSYFKCAELTCPVKKQVIQQDSKYINTYRGKHNHDPPESEAIEKRKKHFNGLYNNNNNNNNNNNNNNNNNNNNNNINNINNNNINNLNSLNNINNINNNNNSNQINNFSGSIQNNLKNILKEQLKEAGKLHNEIENNLIDD
Protein: Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (PU.1 interaction partner) (Transcriptional activator PIP) (Q64287)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor PU.1
- Basic leucine zipper transcriptional factor ATF-like
- Myeloid differentiation primary response protein MyD88
- Signal transducer and activator of transcription 3
- Signal transducer and transcription activator 6
- Forkhead box protein P3
- Paired box protein Pax-5
- PR domain zinc finger protein 1
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Trans-acting T-cell-specific transcription factor GATA-3
Sequence:
MNLETGSRGSEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLDDTQMAMGHPYPMTAPYGSLPAQQVHNYMMPPHDRSWRDYAPDQSHPEIPYQCPVTFGPRGHHWQGPSCENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRDILVKELTTTSPEGCRISHGHTYDVSNLDQVLFPYPDDNGQRKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNTGHFLRGYELPEHVTTPDYHRSLRHSSIQE
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (H2FLL8)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED
Protein: Protein FAM53B (Protein simplet) (F1QN48)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) nuclear localization. Required for appendage regeneration by regulating cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:25183871}.
Interaction partners:
- Chemokine
- Si:ch211-171h4.5.
- Si:ch73-380l3.4
- Si:ch211-69e13.6.
Sequence:
MCVAMVIIHTKTLEKKAVDDVTSEASLQPQEPLTMSQGTALFSCGIMDSGRWADVGSVCGVQQRPVGSSLESLWDSMREAGATGGISGLLRDLSLSEASPASAAPPSKRQCRSLSCSDELGCRSSWRPQGSRVWTTVEKRRCHSGGSVQRGVFNPSGFPAMQRSSSFSLPAHSSHLEPFTHGFPFQAFSECPQTPQTLYRSHEQICPAEASSPESTPELQRRSGQSGLARSRSQPCVHNHQKIGVKRRRPADSHKQRPSLDLLKMTQKLQDFHSLSCPGFSGDDKTLPSSSPALLNDTCERAQNDSSADAPIHQSESSSEDALIHQSDSSSADALIHQSESSRPAGKERECLWAGLCSRRGRDLFQLGGELDIEQIERN
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (A0A2R8Y883)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKLGLPTGHFVMAAQRQKRGK
Protein: AraC-family transcriptional regulator (Q9L062)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Interaction partners:
- Oligoribonuclease
- DNA-binding protein
- RNA polymerase sigma factor WhiG
- Regulator
- Secreted protein
- RNA polymerase principal sigma factor HrdB
- Probable cell division protein WhiA
- HTH-type transcriptional repressor DasR
Sequence:
MSHDSTAAPEAAARKLSGRRRKEIVAVLLFSGGPIFESSIPLSVFGIDRQDAGVPRYRLLVCAGEDGPLRTTGGLELTAPQGLEAISRAGTVVVPAWRSITSPPPEEALDALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVDPRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGNEAAGALARRLVVPPRRSGGQERYLDRSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARRPQGDRQPDPDTAAAGATRPLPPSDPPASLAPENAVPFQTRRTATPMPAGAASVPGQRSAP
Protein: Protein MGA2 (P40578)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Acyl-CoA desaturase 1
- E3 ubiquitin-protein ligase RSP5
- Protein SPT23
- Nuclear protein localization protein 4
Sequence:
MQQNSEFLTETPGSDPHISQLHANSVMESQLLDDFLLNGSPMYQDDSMAHINIDEGANFQNFIKTDEGDSPNLLSFEGIGNNTHVNQNVSTPLEEEMESNRALKEEEEDEHENKVFNEKNIGNPAHDEIVFGRKETIQSVYINPLDYLKVNAAQLPLDVEVSGLPQVSRVENQLKLKVKITSETPLNQSMLYLPSDSISREKFYLKKNIEDFSEDFKKNLLYINAFVLCAVSNRTTNVCTKCVKREQRRAARRKSGIADNLLWCNNINRRLVVFNNKQVFPIMKTFDNVKEFELTTRLVCYCRHHKANNGFVILFTITDWQNRLLGKFTTTPIMITDRKPANMDTTKFNNTTTSSRRQLTEEESTTEYYSTDNNQLSKDENMPFQYTYQHNPYDNDSQMNNIPLKDKNVPFPYSISQQTDLLQNNNLSLNLSLPNQHIPSPTSMSEEGSESFNYHHRDNDNPVRTISLTNIEQQSQLNQRKRARNNLENDIGKPLFKHSFSNSISATNTMNPALHSMQDFSMKNNNNNLPSINRVIPSQGPINGGIEVTLLGCNFKDGLSVKFGSNLALSTQCWSETTIVTYLPPAAYAGQVFVSITDTNNENNNDDLPQEIEINDNKKAIFTYVDDTDRQLIELALQIVGLKMNGKLEDARNIAKRIVGNDSPDSGTNGNSCSKSTGPSPNQHSMNLNTSVLYSDEVLIQKVIKSLNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLLNCKVNYSLRSHNGLTAREVFIANHIHSKEIDKKQDNRDNHKFVHNDTYISEVLSLFEEFQNGTKFTDSVETDSNYSISRKYSQSSFNSSLLDNESLNENLFESQSMINPTSMEIQHPTLQLFENSSYSEYDQSDFEEDGDEDLFVTDEVEKPGVACREEQSELLDIGSSANEPEEDNGSTSLWNRVLHRINDDLPKYEDLFPLSWGKDDKLKTTNQDSIVEQSASNIENSENSEEEDYEEEEEFLKKQFNRFFQNKQNFRNDKMLIFFWIPLTLLLLTWFIMYKFGNQDSSINHISELISEYLRIALAKFLLGNERMKTAFRSKLSNLQTTRMLNDLIVS
Protein: RNA helicase (EC 3.6.4.13) (M9PBB5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDDWDDEPIVDTRGARGGDWSDDEDTAKSFSGEAEGDGVGGSGGEGGGYQGGNRDVFGRIGGGRGGGAGGYRGGNRDGGGFHGGRREGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGGFRGGEGGFRGRLYENEDGDERRGRLDREERGGERRGRLDREERGGERGERGDGGFARRRRNEDDINNNNNIVEDVERKREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEHQTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVPDFLRTCGAGGDGGYSNQNFGGVDVRGRGNYVGDATNVEEEEQWD
Protein: Defensin-like protein 205 (Q9M9M3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Defensin-like protein 197
- Defensin-like protein 194
- Putative defensin-like protein 203
- Late embryogenesis abundant domain-containing protein / LEA domain-containing protein
- Probable NOT transcription complex subunit VIP2
- TSK-associating protein 1
- Defensin-like protein 10
- Protein PHLOEM PROTEIN 2-LIKE A5
- Defensin-like protein 272
- Defensin-like protein 183
Sequence:
MAKTLNSICFTTLLLVLLFISAEIPTAEANCDTYLGEVTVYYPCRERDCEAQCYEHYPHSCKGECEHHDHVVHHDNEEEHCHCYGR
Protein: LIM domain-binding protein 1 (LDB-1) (xLdb1) (P70060)
Organism: Xenopus laevis (African clawed frog)
Function: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. Acts as a coactivator together with otx2 to stimulate lhx1/lim1-mediated activation of the gsc promoter in the Spemann organizer. Acts synergistically with lhx1/lim1 and ssbp in axis formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:8918878}.
Interaction partners:
Sequence:
MLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKESFHNNFVSLDCDQCTMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQAPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ