wanglab/gogpt-training-data huggingface dataset:
Protein: Sporulation-specific protein SPO7 (P18410)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1. Essential for the formation of a spherical nucleus and meiotic division. The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9822591}; Multi-pass membrane protein {ECO:0000269|PubMed:9822591}. Nucleus membrane {ECO:0000269|PubMed:9822591}; Multi-pass membrane protein {ECO:0000269|PubMed:9822591}.
Interaction partners:
- Nuclear envelope morphology protein 1
- Phosphatidic acid phosphohydrolase 1
- Nucleoporin NUP84
- Diacylglycerol pyrophosphate phosphatase 1
- CTP-dependent diacylglycerol kinase 1
- Lipid phosphate phosphatase 1
- Nucleoporin NUP120
- Nucleoporin SEH1
- Nucleoporin NUP85
- N-terminal acetyltransferase A complex subunit NAT1
Sequence:
MEPESIGDVGNHAQDDSASIVSGPRRRSTSKTSSAKNIRNSSNISPASMIFRNLLILEDDLRRQAHEQKILKWQFTLFLASMAGVGAFTFYELYFTSDYVKGLHRVILQFTLSFISITVVLFHISGQYRRTIVIPRRFFTSTNKGIRQFNVKLVKVQSTWDEKYTDSVRFVSRTIAYCNIYCLKKFLWLKDDNAIVKFWKSVTIQSQPRIGAVDVKLVLNPRAFSAEIREGWEIYRDEFWAREGARRRKQAHELRPKSE
Protein: HSP20-like chaperone, putative (C0H473)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MFFFCFFVFCIFLFFNVVLSKLDFANEQIASSFFESHKNYRVTKEDIIDGIEKCWFNITDYLISESIKQDNDFSNDIKTTVTAMKNKMDQLLTTSYSNKKIDTVNASFQWAQSPEYIFLNIKFSHRWSSPGALKVKDEEIVSKKNNFSFSALSNDSNSVTKKYIVDLTLLDNIIESETKYNFASVGKVVVTLKKEKKKIWNRLLLSKEKYPNMQVWWDMKEKYHDSVQNFLKEEKNNSDKLQDDIDEDEEKYFDEEILREAKKKSEEYDKDDEEL
Protein: small monomeric GTPase (EC 3.6.5.2) (B9EMH1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
- CRK SH3-binding GNRP
- CRK SH3-binding GNRP
- CRK SH3-binding GNRP
- CRK SH3-binding GNRP
- Afadin
- Afadin-like
- Rap guanine nucleotide exchange factor 6-like isoform X6
- Rap guanine nucleotide exchange factor 4
- Rap guanine nucleotide exchange factor 4
- Intersectin-2-like
Sequence:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWNHCAFLESSAKSKINVLDIFYDLVRQINRKTPVEKKKAKKKSNCVLL
Protein: Protein tesmin/TSO1-like CXC 5 (AtTCX5) (Q9SZD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in development of both male and female reproductive tissues.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Retinoblastoma-related protein 1
- Transcription factor MYB3R-4
- Transcription factor E2FC
- Histone-binding protein MSI1
- Transcription factor MYB3R-3
- Transcription factor-like protein DPB
- WD-40 repeat-containing protein MSI5
- Pyridoxamine 5'-phosphate oxidase family protein
- At4g38290
- Proline-rich spliceosome-associated
Sequence:
MGEDGGGGEFPPKKDGVEEGFPTKKPARQLDFTGGSDEHSLSKPAAPTVVATSVKPIISSSVPSTIRPGMTIAIGQVTQVRPTLPMATTMSNPPSQSQIVNAPIRHPIPESPKARGPRPNVEGRDGTPQKKKQCNCKHSRCLKLYCECFASGTYCDGCNCVNCFNNVDNEPARREAVEATLERNPFAFRPKIASSPHGGRDKREDIGEVVLLGKHNKGCHCKKSGCLKKYCECFQANILCSENCKCLDCKNFEGSEERQALFHGEHSNHMAYLQQAANAAITGAVGSSGFAPSPAPKRRKGQEILFNQAIKDSSRLSHFPQVNNGRTGGPTSGTSPSPVSRAGGNASSVPSKFVYRSLLADIIQPHDVRALCSVLVTVAGEAAKTSTDKRNEIENRVDDQTETSLASSAQDQPQGNNNAADVEMVATDHNQADKSGPEESNSDGVDASKVTPLSPATLALMCDEQDTIFMVAAPSPNGSVDPNGCRPNSQGQSEIYAEQERLVLTKFRDCLNRLISYAEIKESKCLSLARMHIQPPAIATVKTENGIQQQVPIVNGASRTNCQPTLNKPQPMQLMNTTSAAPATATNTQHLQKPPALSEKKDP
Protein: DNA-directed RNA polymerase subunit (Q6DGU0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005586}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase III subunit RPC5 isoform X1
- RNA polymerase I and III subunit C.
- DNA-directed RNA polymerase subunit beta
- Polymerase
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
Sequence:
MLLFCPTCGNVLIVEEGQRCFRFACNTCPYVHNITRKVNNRKYPKLKEVDDVLGGSAAWENVDSTAEPCPKCEHPRAYFMQIQTRSADEPMTTFYKCCNIQCGHRWRD
Protein: Regulatory protein NPR2 (BTB/POZ domain-containing protein NPR2) (Q9SZI3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P93002}. Nucleus {ECO:0000250|UniProtKB:P93002}. Nucleus, nuclear body {ECO:0000250|UniProtKB:P93002}. Note=Accumulation in nucleus after induction by salicylic acid (SA) treatment or after pathogen infection. {ECO:0000250|UniProtKB:P93002}.
Interaction partners:
- Transcription factor TGA6
- Transcription factor TGA5
- Transcription factor TGA2
- Transcription factor TGA7
- Transcription factor TGA4
- AT3G13950 protein
- Transcription factor TGA3
Sequence:
MATTTTTTTARFSDSYEFSNTSGNSFFAAESSLDYPTEFLTPPEVSALKLLSNCLESVFDSPETFYSDAKLVLAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQLKEIARDYEVGFDSVVAVLAYVYSGRVRSPPKGASACVDDDCCHVACRSKVDFMVEVLYLSFVFQIQELVTLYERQFLEIVDKVVVEDILVIFKLDTLCGTTYKKLLDRCIEIIVKSDIELVSLEKSLPQHIFKQIIDIREALCLEPPKLERHVKNIYKALDSDDVELVKMLLLEGHTNLDEAYALHFAIAHCAVKTAYDLLELELADVNLRNPRGYTVLHVAAMRKEPKLIISLLMKGANILDTTLDGRTALVIVKRLTKADDYKTSTEDGTPSLKGGLCIEVLEHEQKLEYLSPIEASLSLPVTPEELRMRLLYYENRVALARLLFPVETETVQGIAKLEETCEFTASSLEPDHHIGEKRTSLDLNMAPFQIHEKHLSRLRALCKTVELGKRYFKRCSLDHFMDTEDLNHLASVEEDTPEKRLQKKQRYMELQETLMKTFSEDKEECGKSSTPKPTSAVRSNRKLSHRRLKVDKRDFLKRPYGNGD
Protein: Homeobox even-skipped homolog protein 2 (EVX-2) (Q03828)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus.
Interaction partners:
- Endoplasmic reticulum junction formation protein lunapark
- Metaxin-2
Sequence:
MMERIRKEMILMERGLHSPTAGKRFSNLSNSAGNAVLEALENSQHPARLSPRLPSAPLHSALGELPAKGKFEIDTLFNLQHTGSESTVSSEISSAAESRKKPGHYSEAAAEADMSSDVEVGCSALRSPGGLGAAQLKENNGKGYAESGSAAGTTTSASGSGLGSLHGGSGGSGGSAALGGSGSGADQVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAASGAAAAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQAPAAAAGLNSAASAAAAAAAAAAAASSAAAAGAPPSGGSAPCSCLSCHSSQSAAAAAAAAAAALGSRGGGGGGGGGGGGGGGGAGAGGGSDFGCSAAAPRSESGFLPYSAAVLSKTAVSPPDQRDEAPLTR
Protein: Unc-13, isoform F (L0MPR2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTHYVRHDYFHNTQNGALSSDTSRISYSQISYETQPSREYFSESYALSNQGPEECSRVSHLNSDTVLTTVDNSNNSYGYDYLECYGANIQCDPEEDSVDNWNENTSVVADQYGLGHNNLNCTSSKLLPKLPNIENGRGSSNACAPQMDVKFNTKDAAQRDGRGFDTDQTDAMGSESSTYEVYEKMQRPYTSMLPLDYSDYQEGCYNTDNLSTYSDTPPSNNTQLKRQMQRKISLMMAMTTASVIASGNTISTNAAARDLDRCLATESCEVIVDTRDSGSVTSFPSSAVTAITKTRKLPKVLPTPLCKSSRHPITIATDALSSSYTSDPLPEKSHRPKQLPKLPISLPQSNDRASLNSNWATPPAPDALPFNSFDHKSASSPTPTTTITKDTETTSYLVETDFIGARHNALYQYDSKEPNIVFSDKSVEAEHSPTWTPLSPIQSKQSPCPPVALPSNIMQNVSLTCHLPEIEATRSDIEREPESSSIEPILEIEKLADPYSGPGSALFNISEYLKPYTLNKPILSEEKKNHIANAASTSTTTPLNITSDDEFSSYSNKWTSTCVNFQPLDVESSLNISLKVNAGTNQAELLMTPLKSSTPLFISSNGTSDNFNLRKSSPPDSAFTTTVNVNSFETVLVSGSQTASPSPSNLKSPPSIAPLLSYSDYMKQFELPELPQPIMDLSENDTATQSDSFNVINNTLTNADNLNSYNQMDVESKSSLQLPSYSSESFDPCSVPSFSIKNKEYKIVEKLDSLSNVESVESPKTLVSPVNPLNCSKLLPGTESIVSNDVAFDDTFYDSFNVDIKELTAFVDHVAPEDGLYNFPNDKTSVEFSFDKTEDTIDMNQNLSSGECGYYKPSQAQQKASVVASAASSVLDGISKGLKGGLDGVFSGVSSTVDVTQSNPSSKRGFSFNLASKIVPSVGGLLTSTSSTSIKQTGSETNPTLILISPENVSSRNSNYIPTTSPSCTQKNGEENLYSATVHNKSTKSNSYYNEVGEISSTLVRNVCDSYDNSYDEMILTNEMVNIGMLDSESEFGLIENSYSYQVPDNEQIDSVNSYNNKTQNVTNNGIEKANTKNKPVPLHDPPTKKASTVGMFGSILGKAAAAVQSATQAVNQSASSVASVVAQKPTIVPRTNNVLLLSSVCSPNEIKRNSSSVEFDSEYGYQMPDVESLSSHYANTGGDYDNSNMKIHEFGTYADDRPYADYHTNGNQSQFKEEAVIPGEPEVINTNILPIGPQATGKKLPTVNGKSALLIKQMPTEVYDDESDTDELDVSPSTGKVPSYSIYSEQEDYYMDLQQTTPSIQPNGFYEQVNNGYDYREDYFNEEDEYKYLEQQREQEEHNQPKNKKYLKQAKISKIQPPSLDFIDVGQDDDFIYDNYHSEDDSGNYLEGSSSGSVGPIEGSIIKVDSNIEASFASLNKKSDSFTPTNDSLQKHDTVIGESTTKLTRLRTEKMCPDVDEEDENLSDHVSDLTDLSKLISQKKKTLLRGETEEVVGGHMQVLRQTEITARQRWHWAYNKIIMQLNNGGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKANYPNAPSKMDQCYLLSLQENVETTTMAATKRNAGLTSAVPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELISECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCEENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPEHMKDERIACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQNLNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGGSGTLAAGNLAAQRNAVAVEADEVLRPLMDLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEKTIVLPPMTDKTMMFKHLTDNAKNLASNAKIEDMGRLFKSHMAGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKTFISSQVHEVDLENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAANDLKWQIPSGMFRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHICVKDYCFARDDRLVGVAVIPLKDISEKGSVACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFVKLKSEIRQEPTMGT
Protein: Atypical chemokine receptor 2 (V9GYX0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWA
Protein: Probable transcriptional regulator RABBIT EARS (Q9LHS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator essential for petal development. Required for the early development of the organ primordia of the second whorl. Acts downstream of AP1 and PTL.
Subcellular location: Nucleus {ECO:0000269|PubMed:14681191}.
Interaction partners:
- Zinc finger protein JAGGED
Sequence:
MMDRGECLMSMKLRPMVTRPSSDGTLFWPFREERAFASAEEYGGGGGCMWPPRSYSCSFCGREFKSAQALGGHMNVHRRDRARLKQQSLSPSSTDQATPPECDRQQQVLDVGSKVLVQEETRKPNGTKREISDVCNNNVLESSMKRYEHDNGEVKTDLSVGLLSTEFDPRKKQLINGSSSSWKRAKTDVSRFPMMLGLVIGISEINGHHEELDLELRLGADPPKVN
Protein: cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) (P10644)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23115245}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase type I-beta regulatory subunit
- cAMP-dependent protein kinase type II-beta regulatory subunit
- cAMP-dependent protein kinase catalytic subunit PRKX
- A-kinase anchor protein 10, mitochondrial
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
- Guanine nucleotide-binding protein G
Sequence:
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
Protein: Vesicular integral-membrane protein VIP36 (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36) (P49256)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.
Subcellular location: Golgi apparatus membrane; Single-pass type I membrane protein.
Interaction partners:
- Ubiquitin conjugating enzyme E2 J2.
- Mannosyl-oligosaccharide glucosidase.
- Derlin
- Protein transport protein SEC23
Sequence:
MAAEGWIWRWGWGRRCLGRPGLPGPGPGPATPLFLLLLLGPVVADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTILTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMVEHTPDEENIDWTKIEPSVNFLKSPKDNVDDPTGNFRSGPLTGWRVFLLLLCALLGIIVCAVVGAVVFQKRQERNKRFY
Protein: Ras-related protein Rab-8B (EC 3.6.5.2) (P61028)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome membrane {ECO:0000250|UniProtKB:Q92930}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-8A
- MICAL-like protein 2
- PEX5-related protein
- Rab-3A-interacting protein
- Inositol polyphosphate 5-phosphatase OCRL
- Rab GDP dissociation inhibitor alpha
- Guanine nucleotide exchange factor for Rab-3A
- Rab GDP dissociation inhibitor beta
- RILP-like protein 2
- Serine/threonine-protein kinase TBK1
Sequence:
MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEEAFFTLARDIMTKLNRKMNDSNSSGAGGPVKITESRSKKTSFFRCSLL
Protein: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase stabilizing protein GtfB (Glycosyltransferase chaperone Gtf2) (Glycosyltransferase stabilizing protein GtfB) (Glycosyltransferase-stabilizing protein Gtf2) (Q3S2Y1)
Organism: Streptococcus agalactiae
Function: Required for the polymorphic O-glycosylation of the serine-rich repeat protein Srr2. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat proteins, probably Srr2 in this organism. The GtfA-GtfB (Gtf1-Gtf2 in this bacteria) complex adds GlcNAc from UDP-GlcNAc to Srr2 substrate, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA in vivo. Upon expression in a gtfB deletion mutant of S.parasanguis, GtfB confers incorrect glycosylation and partial complementation of a biofilm formation defect, while GtfA/GtfB restores correct expression of serine-rich repeat protein Fap1 and completely restores a biofilm formation defect in a S.parasanguis double gtfA-gtfB deletion.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01473}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01473}.
Interaction partners:
Sequence:
MIILFDFFDKKSKDLYYSLITSGLHGNAVVINDDGFLPQNINSPYSFFCNMEGKNGNPLYFNQVPLPDLWEIKGNNIEAEIWDFSIKRAKIFYQEPKYKRQVKNIDWFDNNKKVRYTDHYNRFGWCFARTHFDKNQNVTTKSYFDKDGKEVIVENFRTGVIILNWLNKDYFFDNRVAFLNFYFSLMGWNLSRIWYNSLSTPFFVSYRMTYPGEDILFWQEDIEDTIPANMRVLLESTNTRTQKVIVQKKNTYHKIKSMLPKEQQEKIGYLGFIYPNKKNNKGRKDIFILTNSDQIEHLEVLVHHLSDYHFHIAAYTEMSFKLMSFSQEQNVTLYPNISRTDLDNLFEICDIYFDINHGNEVDDVIRRAFEYNHLIFAFDNTCHNRELVLDSNIISHTTCEQLINLMKNLSGSIMYLLEQQREQTSNETKERYKEILGGYGNA
Protein: Miniconductance mechanosensitive channel YbdG (P0AAT4)
Organism: Escherichia coli (strain K12)
Function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:20616037}; Multi-pass membrane protein {ECO:0000269|PubMed:20616037}.
Interaction partners:
- Mechanosensitive channel MscK
- Moderate conductance mechanosensitive channel YbiO
- Small-conductance mechanosensitive channel
- Miniconductance mechanosensitive channel MscM
- Large-conductance mechanosensitive channel
Sequence:
MQDLISQVEDLAGIEIDHTTSMVMIFGIIFLTAVVVHIILHWVVLRTFEKRAIASSRLWLQIITQNKLFHRLAFTLQGIIVNIQAVFWLQKGTEAADILTTCAQLWIMMYALLSVFSLLDVILNLAQKFPAASQLPLKGIFQGIKLIGAILVGILMISLLIGQSPAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIPTWSLVSDSFKNWSGMSASGGRRIKRSISIDVTSIRFLDEDEMQRLNKAHLLKPYLTSRHQEINEWNRQQGSTESVLNLRRMTNIGTFRAYLNEYLRNHPRIRKDMTLMVRQLAPGDNGLPLEIYAFTNTVVWLEYESIQADIFDHIFAIVEEFGLRLHQSPTGNDIRSLAGAFKQ
Protein: Mannose-1-phosphate guanylyltransferase catalytic subunit beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) (Q6DBU5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
Interaction partners:
- Phosphomannomutase
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-A
- GDP-mannose 4,6 dehydratase
- Dolichol-phosphate mannosyltransferase subunit 1
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B
- Phosphomannomutase
- Dolichol-phosphate mannosyltransferase subunit 3
- Dolichol phosphate-mannose biosynthesis regulatory protein
- ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.
- Protein O-mannosyl-transferase 2
Sequence:
MKALILVGGYGTRLRPLTLTVPKPLVEFCNKPILLHQVEALVKAGVRHVILAVSYMSELLEREMRAQEQRLGIKISLSHEKEPLGTAGPLALARELLTDNQEPFFVLNSDVICDFPFDDMLKFHQQHGREGTIVVTKVEEPSKYGVVVYEGDSGRIHRFVEKPQVFVSNKINAGMYIFSPAMLRRIQLRPTSIEKEIFPVMAEEGQLYAMELQGFWMDIGQPKDFLTGMCMYLQSVRQQAPERLRAGPGFLGNVLVDPTAVIGQNCTIGPNVTIGAGVVLEDGVRVKRCTILKGAHIRSHSWLESCIVGWSSSVGQWVRMENVTVLGEDVIVNDELYINGANVLPHKSITDSVPEPRIIM
Protein: Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1) (Q6UWP2)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- 17-beta-hydroxysteroid dehydrogenase type 1
- 17-beta-hydroxysteroid dehydrogenase type 2
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- 17-beta-hydroxysteroid dehydrogenase type 6
- Very-long-chain 3-oxoacyl-CoA reductase
- Peroxisomal multifunctional enzyme type 2
- (3R)-3-hydroxyacyl-CoA dehydrogenase (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (KAR alpha subunit) (Estradiol 17-beta-dehydrogenase 8) (Protein Ke6) (Ke6) (Testosterone 17-beta-dehydrogenase 8)
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- Fibrous sheath-interacting protein 1
- 3-hydroxyacyl-CoA dehydrogenase type-2
Sequence:
MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT
Protein: NAD(P)H-quinone oxidoreductase chain 4, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase, chain 4) (NADH-plastoquinone oxidoreductase chain 4) (Q6ENA7)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00491}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00491}.
Interaction partners:
- NAD
- NAD
- NAD
- NAD
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Uncharacterized protein
- Uncharacterized protein
- NAD
- NAD
- Plus3 domain-containing protein
Sequence:
MSSFPWLTILVVLPIFAGSLIFFLPHRGNKIVRWYTMSICLLEFLLMTYAFCYHFQLEDPLIQLKEDSKWIDVFNFHWRLGIDGLSLGSILLTGFMTTLATLAAWPVTRNSRLFYFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKRRLYSATKFILYTAGGSIFFLIGVLGMGLYGSNEPRLDLERLINQSYPATLEILFYFGFLIAYAVKLPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRINMELLPHAHYLFSPWLVIIGAMQIIYAASTSLGQRNFKKRIAYSSVSHMGFIIIGIGSITNIGLNGAILQILSHGFIGATLFFLAGTACDRMRLVYLEELGGVSIPMPKIFTMFSSFSMASLALPGMSGFVAELVVFFGLITSPKFLLMPKMLITFVMAIGMILTPIYLLSMLRQMFYGYKLFHVPNENFEDSGPRELFLLICIFLPVIGIGIYPDFVLSLSVDRVEALLSNYYPK
Protein: TATA box-binding protein-like 1 (TBP-like factor) (Q8T052)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQNDMVSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAPRVYLTPSSTFMTNRQMAGVASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGPSLQRKLANGDTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSITVIDDDDEEKKEVAEDEEESSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYRRENGMVTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVTAASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRLQAGGDPHELEKNVLADNKTASLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPRLKQMVNYHQMMKQTQEERRHIMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANARRRATECWATKLQNKRPRYNDPGTTGTINAASSTASAATSSLASQATHLRNPLKTAALANARMLGAKVTTCTRNSIIVQQPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEENNELDMPF
Protein: RIMS-binding protein 2 (RIM-BP2) (Q80U40)
Organism: Mus musculus (Mouse)
Function: Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular location: Cell membrane {ECO:0000250}. Synapse {ECO:0000250}. Note=Synaptic plasma membrane. {ECO:0000250}.
Interaction partners:
- Regulating synaptic membrane exocytosis protein 2
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Protein bassoon
- Regulating synaptic membrane exocytosis protein 1
- Protein unc-13 homolog B
Sequence:
MREAAERRQQLELEHEQALAFLNAKQQEIQLLQQAQVEAKKEHEGAVQLLESKVRELEEKCRVQSEQFNLLSRDLEKFRQHTGSIDLLGSSSVALLDVPLAPGKPFPQYMNGLATSIHKGHEGPTGHYSVIGDYIPLSGDKLESPCVKPSFLLRSSSPRCRFESEMDNDRNSNNSKQSSSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFIQDNESRLAGTLGSEQDQNFLNHSGISLERDSILHLHSPTQVDSGITDNGGGTLDVNIDDIGEDTVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMSLALGRRTKALIEKLNTAACTYRISVQCVTSRGNSDELQCTLLVGKDVVVAPSQLRVDNITQISAQLSWLPTNSNYSHIIFLNEEELDIVKAARYKYQFFNLRPNMAYKVKVLAQPHQMPWQLPLEQREKKEACVEFSTLPAGPPAPPQDVTVHAGATAASVQVSWKPPALTPTGLSNGANVTGYGVYAKGQRVAEVIAPTADGTAVELIRLRSLEAKAVSVRTLSVQGESMDSALAAIPPDLLVPPAPHPRTAPPPKPLASDMDTKDQHLGPHVKVDESWEQSRSPGPAHGHMLEPPDMHSAGPGRRSPSPSRILPQPQGAPVSTTVAKAMAREAAQRVAESNRLEKRSLFLEQSSAGQYTNSDEEDGYASPEVKRRGTSVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGTSHNALKILGNSTLMGRADRMEHVSRRYSHSGGGSHRHRPAMAPSIDEYTGRDHLSPDFYDESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIHADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRGHSVPTRRMVALYDYDPRESSPNVDVEAELPFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDVEVHLSDAPPHYSHDPPMRSKAKRKKSVHFTP