wanglab/gogpt-training-data huggingface dataset:
Protein: Anthranilate phosphoribosyltransferase (F4I5H7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- indole-3-glycerol-phosphate synthase
- Indole-3-glycerol phosphate synthase, chloroplastic
- N-
- N-
- N-
- Anthranilate synthase alpha subunit 2, chloroplastic
- Tryptophan synthase
- Tryptophan synthase alpha chain
- Protein PHYLLO
- Tryptophan synthase alpha chain, chloroplastic
Sequence:
MKALLNPESSFCLSSISSSQIKRSLHFNGLSSSCLRFPLTDFAGRLRRRKLTGGLCIKAVLDSAMMEQLGLKESDVKNPALSSTYRGSEIPKPNLTVLDAQARVCTGPTQTRPLSEEQAFKVFDTILRSARGELKDEEPVSKAQLGAFFAGMTIRANAFPEETQWSEGEKRAMDVFWPLLVRALPPDVLFIADPEGSLLGTGNSVGPTFVGNETREMRLVGALREILAGGHLGYEEVKGVLRDVLPLETEGSLNSGVSESLLSAFLIGQRMNRETDRELKAYCLAFDDEHGAPPVADVKSLTHYGEPYDGNTRFFRSTLFVAAVRSCCGESSLLHGVEWMPPKGGVTEEQMLKFMGANTHLSVQQAKELIEDEKAGFAYLSLREARPSLYSLIEMREHIKKRPPLATTEKVQQFVRATGKEAIVAGFYHEGYEEPLLMLMRRRGVHSGLVVKVESLSFTIKYILMPYELLHTWDVDLEPEFCWKLFPYEGEEGALSMTTRVRAASASKGFPVNYCSGFRSLSSDTALEADGVSRQSFNLEVDARNYGFEPTETPRTDRSVSKNIELGLAALRGEKGAAYDRIVLNAGIVDHLLGSEGAEDVAVAMERAKEAIDSGKALKKLLNYIEISRKIK
Protein: Puratrophin-1-like, isoform A (Q7KU89)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFQLRREVWSERLGVWVQRVLVIVLHLWHRSSMSFVRRRQEAFKWIRRRLARRQCHADTNIETGRAEAAVTGSGAGAELAEILVPSDTQIDVPGGGIPGGQIPSLESTDRDMKEARAAPIARDDEDQEAGDPEEHGEEEDEEPPEVEQLSANANYVCCRYPGTTSSSTSGAADTLNRSKSRVQKYLKKCKQRLTGQAKMPTSSSTTTTTITLIRNEPAPTTIAERESEQALAEQEEELLEVEDLTEGSNGSYTDALPIECSLSASIAEEQQQGVDELEPPKEEEVPLETELTEPSSTPPPQSNPEGIPAPERFRLTADVDATLARLIDSHLSHIYPVYWARTRAILIQQARERLVCGFDGSLVRFEQRFLCKFAQIAATLRTAHQIGESWLWHPGWPLATSNGALVLQLSDAEIAHALRPSELYLCIKLESTESDADCKPRLYAVWRSSRKEESVQSHCIDHENPGELPLSVLQLEMSTAAAALMASDCGELPQLLQNLLVSVERSIERVSLNELQMPMHHDRGEDSLDEANNNGCNNNLLGSPKCALRRSDLITKNKLFNSRYMLRRLTNRQDSMNSTSSGNSNVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNSVGNEASGASTSPALPLYCLGNSFPHIDSDEEASDSIGPGKHHSLETCETELLPSSSIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAACVASAGINCYEMATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMRKTHTLPVASSTPAAAAGKRVSYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSLSSGTSTTSGSSISGGSSSGHNDGGGRHSLHFGKLPGAHSASSTNCSATLELINETQALKLAKSPSGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQLSMESGIVSDMCVTPDQEQSAAESSRSSWSTSTTGASGASTTSASTVILRRYRSYAHAAESASPESGK
Protein: RE31492p (Q8SXI6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRWSARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLGSSSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY
Protein: Caudal type homeo box transcription factor 4 (Caudal type homeobox 4) (Cdx4 protein) (Homeobox protein CDX-4) (A8KBT9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MYVGYLLEKEASMYHQGAVRRSGISLPPQNFVSTPQYSDFTGYHHVPNMETHAQSAGAWGAPYGAPREDWGAYSLGPPNSISAPMSNSSPGPVSYCSPDYNTMHGPGSAVLPPPPENIPVAQLSPERERRNSYQWMSKTVQSSSTGKTRTKEKYRVVYTDHQRLELEKEFHFNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKLIKKKLGQSDGSGGSVHSDPGSVSPLPVPGSLSPSDIHGSLYPAQMNALPSMRNIQQVTVTQ
Protein: Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (P51657)
Organism: Rattus norvegicus (Rat)
Function: Favors the reduction of estrogens and androgens. Uses preferentially NADH.
Subcellular location: Cytoplasm.
Interaction partners:
- Aromatase
- Estradiol 17-beta-dehydrogenase 2
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Dehydrogenase/reductase SDR family member 11
- Very-long-chain 3-oxoacyl-CoA reductase
- Estrogen sulfotransferase Ste2
- Cytochrome P450 1B1
- Cytochrome P450 1A1
- (3R)-3-hydroxyacyl-CoA dehydrogenase (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (KAR alpha subunit) (Estradiol 17-beta-dehydrogenase 8) (Testosterone 17-beta-dehydrogenase 8)
- 17-beta-hydroxysteroid dehydrogenase type 6
Sequence:
MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSLEILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVSGDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI
Protein: Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) (P35813)
Organism: Homo sapiens (Human)
Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Subcellular location: Nucleus {ECO:0000269|PubMed:16751101}. Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}; Lipid-anchor {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250|UniProtKB:P49443}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 4
- Mothers against decapentaplegic homolog 2
- Dual specificity mitogen-activated protein kinase kinase 3
- Mothers against decapentaplegic homolog 3
- Dual specificity mitogen-activated protein kinase kinase 7
- Dual specificity mitogen-activated protein kinase kinase 6
- Protein phosphatase PTC7 homolog
- Protein phosphatase 1B
- Chloride intracellular channel protein 4
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Sequence:
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW
Protein: Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) (Q92888)
Organism: Homo sapiens (Human)
Function: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-12
- Transforming protein RhoA
- CD44 antigen
- Guanine nucleotide-binding protein G
- Cell division control protein 42 homolog
- Focal adhesion kinase 1
- Protein-tyrosine kinase 2-beta
- Rho guanine nucleotide exchange factor 7
- Rho guanine nucleotide exchange factor 6
Sequence:
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
Protein: Resistance to inhibitors of cholinesterase protein 19 (ICA1 homolog) (P91124)
Organism: Caenorhabditis elegans
Function: May be involved in neurotransmitter secretion. In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11029035}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22654674}; Peripheral membrane protein {ECO:0000269|PubMed:22654674}. Note=Co-localizes with tbc-8 at cytoplasmic vesicle membranes in neurons. {ECO:0000269|PubMed:22654674}.
Interaction partners:
- CARD domain-containing protein
- RUN domain-containing protein
- Rab GTPase-activating protein tbc-8
- Ras-related protein Rab-2
- Uncharacterized protein F54C8.7
- PRKCA-binding protein
Sequence:
MAAQFYERNTSGMNADRFMTRLTDESTVNTMQRHYWTARQFIRTKLGKKEDEHLEASDNELDTCLNLYRSVHGTSFQLLNNVDNYANFLLDETLVQNVLGKYLKEKGKIDKTEAVGRILIAVGRSLLFSSHRLNAARIGVSTFYNKLSVFVERAIGDCSQTIEAVQMCRTEYRGSLLWMKKTSEELDPEVDGSMEKFREAQTTVKSNKERLDRLKTDTLQKVDLLSASRSNLLSYVLTHYQNELYEYYSKTSRAFETLAENINCYNNYDFEILSHLATGTKPERERKSEKEESAKTSQPRGNEEELKNLLFGRESPQFGEEEVQDESRSQCDSPLIEDVDDERRKTGDLLDLESAASIAFPIGPLATLFDTSSFVPPILPPPKPNAVSDDILSLFDGNKANSSGKEASATTMDWQSLIDGFDRENEDNLL
Protein: Rho GTPase guanine nucleotide exchange factor GEF64C (Q8WQM0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MYDKSKKSWSQRLKTLGSGDSVDKNASLAAVSGMQAMQQLQLHMQQQHQQLQQHQQQLQQQQQQQQQQQHMAHHGHPQMLTAYQLPPVPAAEFLPSALSRSMKYAEPWIYGTVRGIPARPSYGYHPHAAAIFAATEGVPGTTALAVVICSCAEYLNGTKRDVKKASVCKKCKGSRLPLATIGGTGGTVRLPAVSGSSSSRRPMAATMRVVSATKKSRPSILDPQKDPYDLMRRTRLLSPEPSSKEADSKSRSRSETVANQPRGRTRTRAPPPPAPIQKSPAVAVPTAVPDPTDCWLMEDNESLLQSSGLASRANSRRSILRCHVNPYDLISSENGKLHSNLRKPNDHFDVADAQLNDDELGERKSKGTSKFYSGNVAAIAGQRISLGDKSGDSSDPGDSYERIIMVSGGESTASNGPRRPPRNKKADEPAEMPAAAGAAGAAGAAATSPPAAAVTAATAVKPKAVTLAKVEKIEKDNESAYTVLTVTPTSPAIKSILKRPTTLELPGVGMSPLPLPPVNNSGLVTPAGKSQFYIPTPTGTAATPTSSSTPMATSTPTPNASITATTAAAGAAITPGSRKKVQFMVEDKIIATTATAATTDDSDASAVATKTNYEYYNRKRNAATATAAAATAASAAAASPPAAATSTDQQEATLFAADIDDEHNFTTSGEAAPPFIKPDSLHYEDVLPGPQIFDSSESSAKLSLPADGSPHVTTSPVSVLPTGTSNGVGGAGLGPGPAGVSGEEAPATAAATAAATQKTTAANRDYDDDDEHNDKDESHDNKPNDLAEREQDREGDKEQGRAGELGISRQEKKDAGGKPAASQKRAAQTTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTMALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEINKSPLSPQRTVVRVAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNLSANAAQPLYQSSVVVNSHSATSVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEISSKDTFIFKAEDGVRTKQWYTQLQYHAQGMGAWRKRRNALANIMINGMLARS
Protein: Sodium/hydrogen exchanger (Q9NGZ4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNLARRACWRIKSYSSESLFKTYASVITDTSANEIDAEAPPPPRDKTKTRIEPQIAPAKRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNAEECQQNPNEINVVGPSDDWDDGLTFTAKSSLAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKRQGDECTDAVQQNEFPAWASNKEYLAYNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSSQPPNAPSTSIHNPRLDKRSQSISSSSLGAGAHQLGPEGHSGPFPVTASHRRNVRRGSMLELSGDTIPEESSYQHGHSKSLCEPADSDEWEGAPLSAAGGANSELLMRMSGREPLLPRPSNTPRAQIRRMNAGAVGGAGVSQAGRKNQVTKALLDYEDSETDSDENDDDEDEDFDSYDDENIVVTTFTTPATGRRPGSSPGSGSEANTATTTTTSIRLTRNNDESII
Protein: Bacteriophage adsorption protein B (Bacteriophage N4 adsorption protein B) (P0AFA5)
Organism: Escherichia coli (strain K12)
Function: Required for bacteriophage N4 adsorption. May be a component of the phage receptor.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Bacteriophage adsorption protein A
- Uncharacterized protein YbcH
- UDP-N-acetylglucosamine 2-epimerase
- Oxygen sensor protein DosP
Sequence:
MDWLLDVFATWLYGLKVIAITLAVIMFISGLDDFFIDVVYWVRRIKRKLSVYRRYPRMSYRELYKPDEKPLAIMVPAWNETGVIGNMAELAATTLDYENYHIFVGTYPNDPDTQRDVDEVCARFPNVHKVVCARPGPTSKADCLNNVLDAITQFERSANFAFAGFILHDAEDVISPMELRLFNYLVERKDLIQIPVYPFEREWTHFTSMTYIDEFSELHGKDVPVREALAGQVPSAGVGTCFSRRAVTALLADGDGIAFDVQSLTEDYDIGFRLKEKGMTEIFVRFPVVDEAKEREQRKFLQHARTSNMICVREYFPDTFSTAVRQKSRWIIGIVFQGFKTHKWTSSLTLNYFLWRDRKGAISNFVSFLAMLVMIQLLLLLAYESLWPDAWHFLSIFSGSAWLMTLLWLNFGLMVNRIVQRVIFVTGYYGLTQGLLSVLRLFWGNLINFMANWRALKQVLQHGDPRRVAWDKTTHDFPSVTGDTRSLRPLGQILLENQVITEEQLDTALRNRVEGLRLGGSMLMQGLISAEQLAQALAEQNGVAWESIDAWQIPSSLIAEMPASVALHYAVLPLRLENDELIVGSEDGIDPVSLAALTRKVGRKVRYVIVLRGQIVTGLRHWYARRRGHDPRAMLYNAVQHQWLTEQQAGEIWRQYVPHQFLFAEILTTLGHINRSAINVLLLRHERSSLPLGKFLVTEGVISQETLDRVLTIQRELQVSMQSLLLKAGLNTEQVAQLESENEGE
Protein: Kappa-casein (P07498)
Organism: Homo sapiens (Human)
Function: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Subcellular location: Secreted.
Interaction partners:
- Alpha-S1-casein
- Beta-casein
- Alpha-lactalbumin
- Intermediate conductance calcium-activated potassium channel protein 4
- Albumin
- Small conductance calcium-activated potassium channel protein 3
- Keratin, type II cytoskeletal 2 oral
- Calmodulin-1
- Nucleoside diphosphate kinase B
- Calcium-activated potassium channel subunit alpha-1
Sequence:
MKSFLLVVNALALTLPFLAVEVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLPNSHPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIITSTPETTTVAVTPPTA
Protein: Elongin-C (Q9BKS1)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cullin-2
- Cullin-5
- RING-box protein 1
- RNA polymerase II transcription factor SIII p18 subunit
- Transcription elongation factor B polypeptide 3
- Leucine-Rich Repeat protein
- Early embryogenesis protein zyg-11
- RING-box protein 2
- von Hippel-Lindau tumor suppressor homolog
- Ubiquitin-like protein NEDD8
Sequence:
MADQNNAIQCDQDAAQPKQYGGIEGPTSQYVKLVSSDDHEFIIKRELALTSGTIRAMLSGPGVYAENESNVVYFREIPSHVLQKVCQYFAYKVRYTHAATEIPEFPIPPDVALELLMAANFLDC
Protein: Neuropeptide B (Preproprotein L7) (hPPL7) [Cleaved into: Neuropeptide B-23 (NPB23) (hL7); Neuropeptide B-29 (NPB29) (hL7C)] (Q8NG41)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.
Subcellular location: Secreted.
Interaction partners:
- Neuropeptides B/W receptor type 2
- Neuropeptides B/W receptor type 1
- Neuropeptide W
- Apelin
- Neuromedin-S
- Galanin peptides
- Neuromedin-U
Sequence:
MARSATLAAAALALCLLLAPPGLAWYKPAAGHSSYSVGRAAGLLSGLRRSPYARRSQPYRGAEPPGGAGASPELQLHPRLRSLAVCVQDVAPNLQRCERLPDGRGTYQCKANVFLSLRAADCLAA
Protein: Leucine-rich repeat-containing protein 9 (Q6ZRR7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIESENLNQEEIIKELCLCNGLSYEMVGQEGSDTSKLEMFFLGYPRIVGLSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQICSFKELTNLTRLPCLKDLCLNDPQYTTNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQIKELADTTAMKKIMYYNMRIKTLQRHLKEDLEKLNDQKCKLQKLPEERVKLFSFVKKTLERELAELKGSGKGHSDGSNNSKVTDPETLKSCETVTEEPSLQQKILAKLNALNERVTFWNKKLDEIEAIYHIEVKQKKKSHGLLIPLLLIELETVGNFHFEEGTRSDDWFNFCYELILSRFCAWDFRTYGITGVKVKRIIKVNNRILRLKFEEKFQKFLENEDMHDSESYRRMLECLFYVFDPEVSVKKKHLLQILEKGFKDSETSKLPLKKEAIIVSNSLSISECPRIEFLQQKHKDEKKISLKHELFRHGILLITKVFLGQSVQAHEKESISQSNYPMVNSVFIPRKYLLNSVMGQRNCDCSVRQCKWFVFDHDLVLPEYVVEFEYITMVKAPSLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEERPRILSIWPSAKILTQVSKLGPHLHLSGNCYLKITALNLDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQEMHNLKGLCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTSSSIRTVDLIPVDQFRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRDIMSSENLPPIMHSLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNSLIPVTHSPMDGRSFGQVKTPPIEITNVLLPSGFSHYLGSDVTLTPEVEEFLGATFQDQIECNCLKRNEHTPRNSPV
Protein: Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) (Q05933)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1
- Proline-rich protein LAS17
- Actin
- Protein LDB17
- Centractin
Sequence:
MPAYHSTFPVDPNTDRMVGNFALLPLNTKFRGPAYPSNSDYDIIDECLDLFRANSFFKNFEIKSPADRVLIYGILFINDCLAHLKITTSFNEAVKVLTNVALDNFTLPGTPGFPLNNVYQVPVQDHNSMDLLKTYIQQFRQELAMRLLERVYSSTDSKEYPSKFWLAFTRRRFMNKSL
Protein: Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) (Peroxisomal protein) (PeP) [Cleaved into: Irisin] (Q8K4Z2)
Organism: Mus musculus (Mouse)
Function: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
Subcellular location: [Fibronectin type III domain-containing protein 5]: Cell membrane {ECO:0000250|UniProtKB:Q8NAU1}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:12112469}; Single-pass membrane protein {ECO:0000255}. Note=Imported into peroxisomes through the PEX5 receptor pathway. {ECO:0000269|PubMed:12112469}.; SUBCELLULAR LOCATION: [Irisin]: Secreted {ECO:0000269|PubMed:22237023}. Note=Detected in plasma following endurance exercise. {ECO:0000269|PubMed:22237023}.
Interaction partners:
- Peroxisomal targeting signal 1 receptor
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Integrin alpha-V
- Fibroblast growth factor 21
- Growth/differentiation factor 8
- Mitochondrial brown fat uncoupling protein 1
- Meteorin
- Peroxisomal targeting signal 2 receptor
Sequence:
MQAARGGAGRPGREGRGLERECERSPGPGVAMPPGPCAWPPRAALRLWLGCVCFALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI
Protein: Large ribosomal subunit protein uL5z (60S ribosomal protein L11-1) (L16A) (P42795)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P0C0W9}. Cytoplasm {ECO:0000250|UniProtKB:P0C0W9}.
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL21x/eL21w
- Small ribosomal subunit protein uS2z
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein eL38z/eL38y
- Small ribosomal subunit protein eS24z
Sequence:
MASEKKLSNPMRDIKVQKLVLNISVGESGDRLTRASKVLEQLSGQTPVFSKARYTVRSFGIRRNEKIACYVTVRGEKAMQLLESGLKVKEYELLRRNFSDTGCFGFGIQEHIDLGIKYDPSTGIYGMDFYVVLERPGYRVARRRRCKARVGIQHRVTKDDAMKWFQVKYEGVILNKSQNITG
Protein: Protein kinase-related protein (Receptor-like tyrosine kinase) (Q6BC88)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MRAGRGGVPGTGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPVTSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVISPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV