wanglab/gogpt-training-data huggingface dataset:
Protein: Transcriptional regulatory protein FixJ (P10958)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Function: FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for FixN activation.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MTDYTVHIVDDEEPVRKSLAFMLTMNGFAVKMHQSAEAFLAFAPDVRNGVLVTDLRMPDMSGVELLRNLGDLKINIPSIVITGHGDVPMAVEAMKAGAVDFIEKPFEDTVIIEAIERASEHLVAAEADVDDANDIRARLQTLSERERQVLSAVVAGLPNKSIAYDLDISPRTVEVHRANVMAKMKAKSLPHLVRMALAGGFGPS
Protein: Zinc finger E-box-binding homeobox 1 (Delta EF1) (Transcription factor 8) (TCF-8) (Zinc finger homeobox protein 1a) (MEB1) (Q64318)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:20346398}.
Interaction partners:
- C-terminal-binding protein 1
- Histone deacetylase 1
- C-terminal-binding protein 2
- Mothers against decapentaplegic homolog 3
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Zinc finger E-box-binding homeobox 2
- Cadherin-1
- Cadherin-2
- Catenin beta-1
- Twist-related protein 1
Sequence:
MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEEESITDAADCEGGMPDDELPADQTVLPGGSDRGGGAKNCWQDNVKDNECDSDAENEQNHDPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASSHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLMPVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSSGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLETNQASLASKEQEAVSASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKEIPAPTNSCKSEKLPEDLTVKSETDKSFEGARDDSTCLLCEDCPGDLNALPELKHYDPECPAQPPPPAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPSTEELSKIADSVNLPLDGVKKWFEKMQAGQIPGQSPDPPSPGTGSVNIPTKTDEQPQPADGNEPQEDSTRGQSPVKIRSSPVLPVGSAMNGSRSCTSSPSPLNLCSARNPQGYSCVAEGAQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSATVSPAVQEPPVKVIQPNGNQDERQDTSSEGVSTVEDQNDSDSTPPKKKTRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDAMEQEDAGPEVLPEVLATEHVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEELQEGKECENPQGEEEEEEEEEEEEEEEEEEEVEADEAEHEAAAKTDGTVEVGAAQQAGSLEQKASESEMESESESEQLSEEKTNEA
Protein: Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) (Q9QZW9)
Organism: Mus musculus (Mouse)
Function: Transcription factor. Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription. Plays a role in establishing motor neuron identity, in concert with LIM domain transcription cofactor LMO4. Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking interactions of ISL1-LHX3 complexes with regulatory elements. Involved in pancreas development and function; may play a role in pancreatic cell fate specification.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10471502}.
Interaction partners:
- Insulin gene enhancer protein ISL-1
- LIM/homeobox protein Lhx3
- DNA-binding protein RFX6
- Pancreas transcription factor 1 subunit alpha
- Insulin gene enhancer protein ISL-2
- Oligodendrocyte transcription factor 2
Sequence:
MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLATTVSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGASTFQLDQWLRASTAGMILPKMPDFSCEAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGTGKGGSEEKTEEELMGPPVSGDKASGRRLRDLRDSDPDEDEDDEEEDNFPYSNGAGAHAASSDCSSEDDSPPPRLGGPGHQPLPQ
Protein: Mitofusin-1 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1B) (Transmembrane GTPase MFN1) (Q8R4Z9)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains (By similarity). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14561718}; Multi-pass membrane protein {ECO:0000269|PubMed:14561718}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Mitofusin-2
- Serine/threonine-protein kinase PINK1, mitochondrial
- Mitochondrial fission 1 protein
- Mitochondrial antiviral-signaling protein
- Non-selective voltage-gated ion channel VDAC1
- Dynamin-like GTPase OPA1, mitochondrial
- Sequestosome-1
- Mitochondrial Rho GTPase 2
- Dynamin-1-like protein
Sequence:
MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMNKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLERELENFSKQFLHPSSGES
Protein: LIM domain-containing protein ajuba (Q5U2Z2)
Organism: Rattus norvegicus (Rat)
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11860269}. Cell membrane {ECO:0000269|PubMed:11860269}. Cell junction {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus (By similarity). Localizes on centrosomes during G2-M phase (By similarity). Colocalizes with GFI1 in the nucleus (By similarity). Preferentially colocalizes with cadherin-adhesive complexes at sites of cell-cell contacts. {ECO:0000250}.
Interaction partners:
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Protein salvador homolog 1
- WT1 interacting protein
- LIM domain-containing protein 1
Sequence:
MERLGEKASRLLEKLRLSDSGSAKFGRRKGEASRSGSDGTPGAGKGRLSGLGGPRKSGHRGANGGPGDEALEPAREQGPLDAERNARGSFEAQRFEGSFPGGPPPTRALPLPLSSPPDFRLETTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGASGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGLPLTTAPSGYSSGGVPSAYPELHAALDRLCAHRPVGFGCQESRHSYPPALGSPGALTGAVVGTAGPLERRGTQPGRHSVTGYGDCAAGARYQDELTALLRLTVATGGREAGARGEPLGIEPSGLEESPGSFVPEASRSRIREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLSARQPPTNYI
Protein: Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) (Q63622)
Organism: Rattus norvegicus (Rat)
Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10779526}; Lipid-anchor {ECO:0000269|PubMed:10779526}. Postsynaptic density {ECO:0000269|PubMed:11095503}. Synapse. Cell projection, axon {ECO:0000269|PubMed:20089912}. Membrane {ECO:0000269|PubMed:11997254, ECO:0000269|PubMed:20089912}. Perikaryon {ECO:0000269|PubMed:11095503}. Note=Concentrated in soma and postsynaptic density of a subset of neurons (PubMed:11095503). {ECO:0000269|PubMed:11095503}.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2B
- Disks large homolog 3
- Disks large homolog 1
- Disks large-associated protein 1
- Disks large homolog 4
- Ubiquitin-protein ligase E3A
- Tight junction associated protein 1
- SH3 and multiple ankyrin repeat domains protein 3
- SH3 and multiple ankyrin repeat domains protein 1
Sequence:
MFFACYCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVILDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Protein: Rac-like GTP-binding protein 1 (OsRac1) (Q9SSX0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Small GTPase playing a general role in disease resistance signaling pathway. Acts downstream of heterotrimeric G protein alpha subunit. Regulates cell death and reactive oxygen species production, probably through NADPH oxidase. Also involved in sphingolipid elicitor (SE)-dependent defense signaling. Activates phytoalexin production and alters defense-related genes. Down-regulates metallothionein 2b, a reactive oxygen scavenger. May control lignin synthesis through regulation of both NADPH oxidase and CCR1 activities during defense responses. Stimulates lignin synthesis in suspension cell culture.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11149940}. Membrane {ECO:0000269|PubMed:11149940}; Peripheral membrane protein {ECO:0000269|PubMed:11149940}. Note=Associated with the membrane when activated.
Interaction partners:
- Os10g0372500 protein
- Expressed protein
- Os05g0392000 protein
- Os05g0392050 protein
- Dol-P-Glc:Glc
- Protein LOL5
- Uncharacterized protein Os04g0629400
- Os01g0913600 protein
- Os06g0318300 protein
- Os02g0719000 protein
Sequence:
MSSAAAATRFIKCVTVGDGAVGKTCMLICYTCNKFPTDYIPTVFDNFSANVSVDGSVVNLGLWDTAGQEDYSRLRPLSYRGADVFILSFSLISRASYENVQKKWMPELRRFAPGVPVVLVGTKLDLREDRAYLADHPASSIITTEQGEELRKLIGAVAYIECSSKTQRNIKAVFDTAIKVVLQPPRHKDVTRKKLQSSSNRPVRRYFCGSACFA
Protein: BG642167 (Male accessory gland protein) (Q3HKQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLAVLTFLVLCGFSFQHQAVADCGAETSDLWKDDTDSDEGTCTQASINNDRKEDPFENDPIIRQSKKKVENNDSMNSEVQLPLFQNIIKIFKFIWLVLSVWMNWK
Protein: High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fc alpha/mu receptor) (mFcamR) (CD antigen CD351) (Q2TB54)
Organism: Mus musculus (Mouse)
Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11062505}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Immunoglobulin J chain
- Tyrosine-protein kinase ZAP-70
Sequence:
MDQGAPAKPSEQKVPSLRTRWEILLLTLCLLHGSSMTPPHRRSHSRWLQAGSPQFRTHLYNVEAHTAPTPLCCWKNSLSGTNALRGPRLVTGNTGGAVTIHCHYAPSSVNRHQRKYWCRLGSPLWICHTVVSTNQYTHPDYRGRAALTDIPQSGLFVVRLLRLSLGDVGLYRCGIGDRNDMLFFSVNLTVSAGPSNTTYAAAPASGEPTTASPGAASSAGNGWTSGITQILEGSGSEWDRTVPTTGTSKTTSSANGRQTLRTARTMVPGTGSREEGSIRAAVPTPEGPSPKSRSMSSTTQGVWLWSTRNSVTPSVTTSEGRRQGTTPETDGPRDETDVRVSPEAPRKTTGTTRPSALISEHVTWETLQDKTEVSKQQMLHSLEELSPAPSAQTLNATCLEVASEEGRSIDGSLENTTEESSPPTPSQLSVAGPVWVSVKGPSMKSALMEGESHTRILTPVSTVLALLLIAALILLKRSLGRQRTSQKKERVPRITLIQMTHFLPDKLPDEGKNFQQSNLLPPQASLTVLENDPRP
Protein: V-type proton ATPase subunit a (Q8IML4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKLRYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKHILRKTQVFFDEQEGGVNQTTESMTRALITDEARTAGASMGPVQLGYMEKSNEREDYLPCFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKSTVMENKFLQLSPKGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQPIAGATSDAEAGGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIENGAAAAEE
Protein: BMP-2-inducible protein kinase (H0Y9P1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSAQLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFDEITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLSWHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQSQQSQPVELDPFGAAPFPSKQ
Protein: Effector protein hopD2 (EC 3.1.3.48) (Tyrosine-protein phosphatase hopPtoD2) (Q79LY0)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Function: Effector showing tyrosine-phosphatase activity required for host defense suppression. Functions inside plant cells causing suppression of HR (hypersensitive response), PR1 gene expression and oxidative burst probably by interfering with a MAPK (mitogen-activated protein kinase) pathway. MAPK cascades are known to activate defense-related transcription factors. Inhibits plant pattern-recognition receptors (PRRs) activation.
Subcellular location: Secreted {ECO:0000269|PubMed:12032338}. Note=Secreted via type III secretion system (T3SS).
Interaction partners:
- Uncharacterized protein
Sequence:
MNPLQPIQHSITNSQMSGGQQLEAEGSQAHNSYSHPDRISLSQLSQSAHLALDHLSTQPNTDHQRVASLVRNAVQDGKFQLQSSNDTQVTYKTSVCPPANADTMGAAHLINNELTVQARLNDQLEYDIVSAHLYGPSEAISIDASSPPSANDLASSGLSERTHLGMNRVLLRYAVPPRETEDQCVMVIDKMPPPKHGKMSFFRTTNDLSKLPLGMETGGLSDLKLAGCERISSVEQVKSIRAALGGGPLTVLDLREESHAIVNGLPITLRGPMDWANAGLSQVDGAARESAMITELKRTKSLTLVDANYVKGKKSNPQTTELKNLNVRSEREVVTEAGATYRRVAITDHNRPSPEATDELVDIMRHCLQANESLVVHCNGGRGRTTTAMIMVDMLKNARNHSAETLITRMAKLSYDYNMTDLGSISALKRPFLEDRLKFLQAFHDYARNNPSGLSLNWTQWRAKIALE
Protein: Histocompatibility antigen 60b (B1B212)
Organism: Mus musculus (Mouse)
Function: Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18209064}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- NKG2-D type II integral membrane protein
- UL16 binding protein 1
Sequence:
MAKSSLSLNWSLLVLLNFLGATLSTGTDSLSCELTFNHRTLHGQCSVNGKTLLDFGDKKHEGNATEMCADLSQSLRELSEGMRNQQSGNDALNVTTQSQYNQGEFIGGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEHWKNKNLEKDIRNVLIIYFSRCLNKLSPHFREMPKSKIKVLDTTQNTNTTQIHPTVNNSQHNSDTQGLSFTWIVIICIGGIVSFMAFMVFAWCMLKKKKGALCCSSSSTT
Protein: C-terminal binding protein 1 (Q5ZIZ6)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQGIRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTMCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVIFYDPYLSDGMERALGLQRVSTLQDLLFHSDCVTLHCNLNEHNHHLINDFTIKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPGVVHPELNGAAYSRYPPGVVSVAPTGIPTAVEGIVPNPMSLSHGLPAVAHPPHAPSPGQTVKPEADRDHPSDQL
Protein: Guanine nucleotide-binding protein subunit gamma (P54406)
Organism: Caenorhabditis elegans
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-1
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein alpha-11 subunit
- Guanine nucleotide-binding protein G
- G protein gamma domain-containing protein
- Guanine nucleotide-binding protein alpha-1 subunit
- Guanine nucleotide-binding protein alpha-17 subunit
- Guanine nucleotide-binding protein alpha-9 subunit
- G protein-coupled receptor kinase 2
Sequence:
MENIKASTEQLCAEANIQRKKVSEVSKELLDFCEKNKTNDMLVSGPTDQHNPFQEKKSCSVL
Protein: Mitotic-spindle organizing protein 1B (GCP3-interacting protein 1) (AtGIP1) (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1B) (AtGIP1B) (Q9M0N8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for gamma-tubulin complex recruitment to the microtubule organizing centers (MTOCs) (By similarity). During mitosis, modulates gamma-tubulin complex localization, spindle stability and chromosomal segregation. Necessary for gametophyte development and embryogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q08AG7}. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, phragmoplast. Nucleus envelope. Note=Reorganized from the nucleus to the prospindle and the preprophase band in late G2. After nuclear envelope breakdown, localized on spindle and phragmoplast microtubules (MTs) and on the reforming nuclear envelope of daughter cells. Present in mitotic microtubule arrays. In interphase cortical arrays, gamma-tubulin complexes are preferentially recruited to existing microtubules, from which new microtubules are efficiently nucleated.
Interaction partners:
- Gamma-tubulin complex component 3
- Gamma-tubulin complex component 4
- Gamma-tubulin complex component 2
- Tubulin gamma-1 chain
- Protein NEDD1
- NAI2-like protein
- SUN domain-containing protein 1
- TSK-associating protein 1
- WPP domain-interacting tail-anchored protein 2
- Zinc finger protein WIP3
Sequence:
MDEEASRTARESLELVFRMSNILDTGLDRHTLSVLIALCDLGVNPEALATVVKELRRESIPDSVTTTPSIH
Protein: dTMP kinase (EC 2.7.4.9) (F4KJ62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNVLANKGMKRICSVSSVQLFSRSFRALASPRSLNYPLQCIKRSSVRMESSNFSSGVRTESSVKPRGALIVLEGLDRSGKSTQCAKLLSFLNGLGHPTELWRFPDRETSVGQMISAYLSNKSQLDDHTIHLLFSANRWEKRSLMEEKLKTGTTLIVDRYSYSGVAFSSAKGLDIEWCKAPEIGLLAPDSVLYLDISPERAAERGGYGDERYERVEFQKKVADFYQTLGDSSWKIINASDAMEEVEKKIQQVVLDQVKECTEGKPLSLLWSS
Protein: enoyl-CoA hydratase (EC 4.2.1.17) (Q8IPE8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTNPAPVANKHLHTKVVNGVLVIKIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGMLEACQTAEEATLISHGAQVMFDRMERSKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVMLGLLPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEYLEKTAVQVANDLASGKLRVNREKSGLVSKIQSFVMDTDFVKNKIFDTARKQVLKASNGLYPAPLKILDVIRAGVDKGTDAGYEAERKGFGELSATPESKGLIALFRGQTECKKNRFGKPERPVKTVGVLGAGLMGAGIVQVSVDKGYQVVMKDATEAGLARGIGQVQKGLETAVKRKRISALERDQTLASLRPTLDYSDFKNADIIIEAVFEDIKVKHRVIKELEAVVPEHCVIATNTSAIPITKIAAGSSRPEKVVGMHYFSPVDKMQLLEIITHPGTSKDTIAQAVAVGLKQGKVVITVGDGPGFYTTRILSTMLSEAIRLLQEGVDPKDLDQYTKKFGFPVGAATLADEVGIDVGSHIAVDLAKAFGERFSGGNLEVMNDLVLAGFLGRKSGKGIFLYDGQKRGTRPVNNDALEIVKQKYALVSKGANAPEDLTLRMVSRFINEAVLCLEEKILDSPLEGDVGAVFGLGFPPFSGGPFRWVDQYGAGKLVSKMQSYAELYGAPFKPAQTLLDMAKDPSKKFYPKTGSSKL
Protein: Fatty acyl-CoA synthetase and RNA processing-associated kinase 1 (EC 2.7.11.1) (Q03002)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative serine/threonine-protein kinase that may be involved in rRNA transcription and ribosome biogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MSYTNKRHTYYGGFTNDLSDTFQYPQRTDEQRRKHVTFGPYILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYIHSKGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEARKADIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPLKFPDYILPIPRDLLRRMLVSDPKKRINLKQIKKHEWLKPHSSFLSITPDEWDKLNNTQSVFRLAKPRRRYGSRPQSSCSTSSLGSRSDKRDSLVIDSTLITFPAPPQESQNHIITRPASIASDQRLSPIRRSNRHNRSNSAASVALQAVVNADREYVLSHEQSLSPVQNIRQTTGNMTASLSPPPAISPGDIIIETTPIKRNTISGSSIVPSLEEESSTTMQTSKIQPNNMASSQNHQYNKNKTQNSLQSAKNFYRTSSSSHTKPRPTSYHPGSYTTPPYNSNTLSIYEINEKAKSSASSQTLNQRDTSPFDSTPYLALDTCITSSSSIESSPKLITHGQFSVAKPSVDLQSVSGDLIKYKRDADVVTRIYDEKYKQKRKSLRYSGIFSDISCDTVTEESDELRPPESPLQQHEGQESIDKAKTEDTSEKGSKSSNIAKATAQKHVNNHLERSLNEAESTKKRFSFLSLYSYDTSKSSLYSSMDSKRKPSPPSQRRPKKDDSYQTNSKNHYITASNMQTSHQVSKDLPAPTMVQNKCTLETKKAVRSNRSSIMVSEVNKASVDNKAAQSPEHSTAKRVLGFFKRRSMKI