wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Q13613)
Organism: Homo sapiens (Human)
Function: Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Z2C4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z2C4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z2C4}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z2C4}.
Interaction partners:
- Polyphosphoinositide phosphatase
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Inositol polyphosphate-4-phosphatase type I A
- Inositol polyphosphate 4-phosphatase type II
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
- Phosphatidylinositide phosphatase SAC2
- Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
- Mastermind-like domain-containing protein 1
- Myotubularin-related protein 5
Sequence:
MDRPAAAAAAGCEGGGGPNPGPAGGRRPPRAAGGATAGSRQPSVETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGESIKAIVKDVMYICPFMGAVSGTLTVTDFKLYFKNVERDPHFILDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKFPINGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYENHVLYPVASLSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAVRAELQKRVEGLQREVATRAVSSSSERGSSPSHSATSVHTSV
Protein: H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5) (Q9WVD4)
Organism: Mus musculus (Mouse)
Function: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}. Endosome membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}. Cell membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}.
Interaction partners:
- Inositol polyphosphate 5-phosphatase OCRL
- Low-density lipoprotein receptor-related protein 2
- Barttin
- Cubilin
- Cofilin-2
- Cofilin-1
- Osteopetrosis-associated transmembrane protein 1
Sequence:
MAMWQGAMDNRGFHQGSFSSFQSSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSNRVMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEHRDKCPEWNSWAQLIINTDQGAFAYIVNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFIVLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGIYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPMPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Protein: Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) (Q9N0Z6)
Organism: Oryctolagus cuniculus (Rabbit)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VDN2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P06685}. Melanosome {ECO:0000250|UniProtKB:P05023}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta-3
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit beta
- Phospholemman
- Sodium/potassium-transporting ATPase subunit alpha
- cAMP-dependent protein kinase
- mitogen-activated protein kinase
- mitogen-activated protein kinase
Sequence:
MGKGVGRDKYEPAAVSEHGDKKGKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGILAATEEDFDNDNLYLGVVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVIYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIVEIPFNSTNKYQLSIHKNLNANEPRHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEVNFPVDNLCFIGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEIRKLIIRRRPGGWVEKETYY
Protein: trypsin (EC 3.4.21.4) (Q3V2E0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNSLLFLALVGAAVAFPVDDDDKIVGGYTCRENSIPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNINVLEGNEQFVNSAKIIKHPNFNSRTLNNDIMLIKLASPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVNNPDLLQCLDAPLLPQADCEASYPGKITNNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCALKDNPGVYTKVCNCGLDSGHHCRKLSIPLKSLCQ
Protein: Vacuolar membrane protein YPL162C (Q12042)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase FPR2
- Vacuolar lysine transporter YPQ1
- Bud site selection protein 22
- Uncharacterized membrane protein YMR253C
- Vacuolar basic amino acid transporter 4
- Vacuolar arginine/histidine antiporter YPQ2
- Protein SSH4
- GTP-binding protein YPT1
- Transmembrane E3 ubiquitin-protein ligase 1
Sequence:
MYVSNGKDTCQLLGPVSLFVQTLMGMTAVIVLLVKRNYEHPRRKMIVWSYDIGKQIIGSLGIHFLNLGISILKKRRRSLFAITAKGNDDEDQCDWYFLNLLLDTTVGIPILWLCLYIIEKVLKSLHFQNIESGNYFPSKTVGSHPRKPLFSAFVKQLLIFIVGLGVMKFCVFLILNYLEDLAYWFADLILGWSDSWPNFQVFLVMFVFPILLNCFQYFCVDNVIRLHSESLTITNAENFETNTFLNDEIPDLSEVSNEVPNKDNNISSYGSII
Protein: Dynein light chain Tctex-type 3 (F7FAB7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDGYQRPCDEIGFNAEEAHNIVKECVEGVLGGNDYNQNSINQWTASIVEQSIAHLVKLGKAYKYIVTCAVVQRSPYGFHVASSCFWTTSDGTCTVRWENRTMNCVVNVFAVAIVL
Protein: Meteorin (Hypoxia/reoxygenation regulatory factor) (Q8C1Q4)
Organism: Mus musculus (Mouse)
Function: Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.
Subcellular location: Secreted {ECO:0000269|PubMed:15085178}.
Interaction partners:
- Fibronectin type III domain-containing protein 5
Sequence:
MLVATLLCALCCGLLAASAHAGYSEDRCSWRGSGLTQEPGSVGQLTLDCTEGAIEWLYPAGALRLTLGGPDPGTRPSIVCLRPERPFAGAQVFAERMTGNLELLLAEGPDLAGGRCMRWGPRERRALFLQATPHRDISRRVAAFRFELHEDQRAEMSPQAQGLGVDGACRPCSDAELLLAACTSDFVIHGTIHGVAHDTELQESVITVVVARVIRQTLPLFKEGSSEGQGRASIRTLLRCGVRPGPGSFLFMGWSRFGEAWLGCAPRFQEFSRVYSAALTTHLNPCEMALD
Protein: Transcriptional repressor Scml2 (Q99MW4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKEEPPRPLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVEKRPRRKRRTRLWRLRTALLGNEEEAPEAAEEPGTSVLTFGDENRTLKDCRGEAAEEPGTSAFTFGDENRTLKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPRGRGFTQPLEDEARPGRDVQVAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKPKGKRVTKSRKDQAQFLADEEAMPALFSALSVSSTERTPPSSSEQPKSSTSGKTKSTSRGAQTSRKSPRKTSVVQPVPKTSKKAGKSKSTGNTSSPKKGITIKIVLPKKKGGKSGKKEKSIPVISSTSSASLSTLMKSSSSNKTSAGPSKIVMSTVCVYINKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDNRGGEMITAFFDGKVHTVQLPPVNSASFALRFLENFCQSLQCDNFLSSQPFRREAQVPTPDTGTDQSKPENGEPKEKRSLKRLSLHPHRSAPVSSKVPRKSGQASKGN
Protein: Bardet-Biedl syndrome 7 protein homolog (Q08C18)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MELNLNHVDYIQVGVTSQKTMKLLPSAGRKSTQKVAVADHDGVVSCFGMKKGEAVPVFKSLPGQKISRPELGGALGTPQEKIFVSSGSEVRGYTKKGKQFLTFEANLTESINAMHVSGADLFVCASYIYNHYCDCKDQDYYLSGDKINDVLCLPVETVGRIVPILACQDRVLRVLQGSELQYDVEVPGPPTVLELHDRDGGKGGEEVLYGTADGKLGLVRIAKSGPVTSWELDNEKKKGGVLCIDTFDIVGDGVKDILVGRDDGTVEVYGLDGSNEPTLRFENVLSESVTSIQGGCVGKEMYDEVLTTTYTGWVSGLTTEPQQMVAGPGEEIKMSQETQGKVAALRAELEQLQLKVLQGREKYQQSSQSSTAVSAVPVFSINDKFTLCQDDASYSLTLEVQTAIDNLLLQSDVPIDLLDVDKNSAVVSFSECDSESNGNFLLATYRCQANTTRLELKVRSIEGQYGTLQAYVTPRLQPKTCQVRQYQIKPLSLHQRTHTIEQERPMNTLRLTGQFSFAEIHSWVVFCLPEVPEKTPAGENITFCFQNTFLGTQLEATYCKGEANFKSDNISTISILKDVLSKEATKRKINLNISYEVNEDSVSHTLRMIHPKLEYQLILAKKVQLIDALKELQVHEGNADFLIPEYRSILDESAQLLEEYKKQPAHLERLYGMITDLFIDKFKFKGQNVKTKVSQLLAILNNYELDSLMEFFSEA
Protein: Chlorophyll a-b binding protein 8, chloroplastic (LHCII type I CAB-8) (P27490)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular location: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAASSMALSSPTLTGKPVETSANPSSQELGGARFTMRKSATTKKVASSGSPWYGPDRVKYLGPFSGESPSYLTGEFPGDYGWDTAGLSADPETFSKNRELEVIHSRWAMLGALGCVFPELLSRNGVKFGEAVWFKAGSQIFSEGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRIAGGPLGEVVDPLYPGGSFDPLGLADDPEAFAELKVKELKNGRLAMFSMFGFFVQAIVTGKGPLENLADHLSDPVNNNAWSYATNFVPGK
Protein: Mitochondrial import inner membrane translocase subunit TIM14 (Presequence translocated-associated motor subunit PAM18) (Q07914)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14517234, ECO:0000269|PubMed:14605210, ECO:0000269|PubMed:14638855}; Single-pass membrane protein {ECO:0000269|PubMed:14517234, ECO:0000269|PubMed:14605210, ECO:0000269|PubMed:14638855}.
Interaction partners:
- GrpE protein homolog
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM44
- Import motor subunit, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit TIM50
- Presequence translocated-associated motor subunit PAM17
- Cytochrome c oxidase subunit 4, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM23
Sequence:
MSSQSNTGNSIEAPQLPIPGQTNGSANVTVDGAGVNVGIQNGSQGQKTGMDLYFDQALNYMGEHPVITGFGAFLTLYFTAGAYKSISKGLNGGKSTTAFLKGGFDPKMNSKEALQILNLTENTLTKKKLKEVHRKIMLANHPDKGGSPFLATKINEAKDFLEKRGISK
Protein: Nucleoporin 37 (Nucleoporin Nup37) (Q6DHK2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPDDTVRSATYTVPCEDYVHVVEFSPYDCGSPASLLAYGGNKYVVVGTCRFKEEDAEVEGVEFNSLQVFMHGVRVDAIAWSPETHLDKLPPVIRFSTAAADRKIRLWTSDLQNSCDVKVMEGHTSYINHLVFEPAEGKQIASVSDDHTCRVWDLDGNETTSFRLRSPGVSVCWHPEDNCKLMVAEKKGTIRFYDLVTQHAILSLDSGQVPLMSADWCLTNTIKVGAVVANDWVIWDITRSSYPLEKRPAHVDKARHFRWSRANENLFATTGYPGKINSQLLVHHLGHPQPVMLGSASVGAGLSWHRTLPLCVIGGDRKLFFWMTEM
Protein: D-xylose-binding periplasmic protein (P37387)
Organism: Escherichia coli (strain K12)
Function: Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose.
Subcellular location: Periplasm.
Interaction partners:
- Xylose import ATP-binding protein XylG
- Xylose transport system permease protein XylH
- Xylose isomerase
- Xylose operon regulatory protein
- Xylulose kinase
- D-xylose-proton symporter
- Inner membrane ABC transporter permease protein YjfF
- Galactofuranose transporter permease protein YtfT
- Autoinducer 2 import system permease protein LsrD
- Autoinducer 2-binding protein LsrB
Sequence:
MKIKNILLTLCTSLLLTNVAAHAKEVKIGMAIDDLRLERWQKDRDIFVKKAESLGAKVFVQSANGNEETQMSQIENMINRGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMINDADIDFYISFDNEKVGELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVDGWLPENALKIMENALTANNNKIDAVVASNDATAGGAIQALSAQGLSGKVAISGQDADLAGIKRIAAGTQTMTVYKPITLLANTAAEIAVELGNGQEPKADTTLNNGLKDVPSRLLTPIDVNKNNIKDTVIKDGFHKESEL
Protein: Pre-mRNA-splicing factor SLT11 (Extracellular mutant protein 2) (Synthetic lethality with U2 protein 11) (P38241)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-processing protein 45
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor SNT309
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22
Sequence:
MNDEINEPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSNNIIKTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEEAKNDMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLRATSDGPSTPLIKNTTALYKNEKGANEVKNLEKYASVDISHILKKLPLNESFLKNPSTKSFFLYNIDASIPEWKITDTVSQLLGIKKWKDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVTPKGLKRGVLLIDRFRIFIIPWSSGFSAASFGTNTAENIKLSLSLNKLIQLELGLSFPTKSTDNAKNDKKKTSKKVHKDRSKKSKPRANKLTI
Protein: Vacuolar protein sorting-associated protein 33A (Protein carnation) (Q9Y1I2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the biogenesis of eye pigment granules. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex.
Subcellular location: Early endosome {ECO:0000305|PubMed:27253064}. Late endosome membrane {ECO:0000269|PubMed:10549280}; Peripheral membrane protein {ECO:0000269|PubMed:10549280}; Cytoplasmic side {ECO:0000269|PubMed:10549280}. Lysosome membrane {ECO:0000269|PubMed:10549280}; Peripheral membrane protein {ECO:0000269|PubMed:10549280}; Cytoplasmic side {ECO:0000269|PubMed:10549280}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Interaction partners:
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 16B
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 8 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Ras-related protein Rab7
- LD34211p
- LD27967p
Sequence:
MFPHLKGHGQRVNLQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTRPKLFADRGIRLLALKPELHLPREVANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEVSGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGKGEFAHRVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKLLARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDLAAEQEFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLEVLLTISNLEKSGLLHLQTESRAYSVLRKTLHLTVDDNVEIEPKDISYVHSFYAPLTARIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVPRVVLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLMSS
Protein: 26S proteasome regulatory subunit RPN3 (P40016)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase RPN11
- 26S proteasome regulatory subunit RPN1
- 26S proteasome regulatory subunit RPN10
- Proteasome subunit alpha type-3
- 26S proteasome regulatory subunit RPN12
- 26S proteasome regulatory subunit RPN6
- Proteasome subunit beta type-4
- Ubiquitin carboxyl-terminal hydrolase 6
- 26S proteasome regulatory subunit RPN5
- 26S proteasome complex subunit SEM1
Sequence:
MASTAVMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTTLTLDPRYIWRSLKDLSSLRNQELLNAETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSVPGSAELRNSYPASFYSVNTEKKTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRSLNLINAKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIASLKHDNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFYLSKINAIQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMGDIPELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDDTYQLCVRLRSNVIKTGIRIISLTYKKISLRDICLKLNLDSEQTVEYMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDPQQVFDERIKFANQLHDEYLVSMRYPEDKKTQQNEKSENGENDDDTLDGDLMDDMSDISDLDDLGFL
Protein: Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (Q4TVV3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays an essential role in splicing, either prior to, or during A complex formation.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q7L014}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q7L014}. Note=Present in Cajal bodies (CBs) and nuclear speckles. {ECO:0000250|UniProtKB:Q7L014}.
Interaction partners:
- Splicing factor 3a, subunit 3.
- Splicing factor 3A subunit 1
- Splicing factor 3B subunit 1
- Splicing factor 3A subunit 2
- Splicing factor 3B subunit 5
- Small nuclear ribonucleoprotein Sm D1
- Splicing factor 3B subunit 3
- MCG1346-like protein
- Small nuclear ribonucleoprotein polypeptide A'
- Branchpoint-bridging protein
Sequence:
MGRESRHYRKRSSSRGRSGSLSKSRSPDSKRSKKDDRTASRTHSRRERSRSRERRRSRERKRQRRSSRDRRRSRSRERRRSKSRSRGRSKEKPENGDQTADKKKIKEEKEEEKPEDQDFDQNTLEEEMRKRKERVEKWREEQRKTAMENIGEIKKELEEMKQGKKWSLEDDDEEQDKAAEAEESERMEEEEVGEEVDPLDAYMEEVKEEVKKFNMGTMKGANDKKGGMSVTKVVTVVKTKKMPHATKKKGELMENDQDAMEYSSEEEEVDLQTALTGFQTKQRKVLEPVDHQKIQYEPFRKNFYVEVPELARMSPEEVSEYRLELEGISVKGKGCPKPIKTWVQCGISMKVLNALKKHNYEKPTPIQAQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHILDQRPVGEAEGPLAVIMTPTRELALQITKECKKFSKSLALRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLGANNGRVTNLRRVTYVVIDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRTMEALARRILSKPVEVQVGGRSVVCSDVEQHVIVIEEEKKFLKLLEILGHYQEKGSVIIFVDKQEHADGLLKDLMKASYPCMSLHGGIDQYDRDSIINDFKNGACRLLVATSVAARGLDVKQLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEGQARYSGDILKALELSGSSVPAELEQLWTNFKEQQKAEGKIIKSSSGFSGKGFKFDETEHALANERKKLQKWALGLHDSDDEDTALDIDEQIESMFNSKKRVKDFSAPGSVSAGSAGGVSGSVSAVSGLGSLSTPSAGNIQKLEIAKKLALRIQAQKNLGAEAQDVMQQATNAILRGGTIIAPSVSAKTIAEQQAEKINAKLNYTPVEKLEEERQAAEAAETVKRYEEELEINDFPQTARWKVTSKEALQRIGEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTSKGRYKVL
Protein: Selenoprotein F (Q9VVJ7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}.
Interaction partners:
- Thioredoxin reductase-like selenoprotein T homolog CG3887
- UDP-glucose:glycoprotein glucosyltransferase
- Methionine-R-sulfoxide reductase B1
Sequence:
MHKCAIFLLLALSCQQIQAELTAADCRALGFIKAQLMCSSCEKLDDFGLDTIKPQCKQCCTLDQQPAAQRTYAKAILEVCTCKFRAYPQIQAFIQSGRPAKFPNLQIKYVRGLDPVVKLLDASGKVQETLSITKWNTDTVEEFFETHLAKDGAGKNSYSVVEDADGDDDEDYLRTNRI
Protein: Kinesin, putative (Q387X3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVRLDPSASTASSMTTTTATSALDVSLTEQDTSRSNGGAQDSAMRVYVRIRPFTASELLENGERPNRTIALDARDGHIKIMDPSRNFTTRLTYVFERCFDSAEAGPGADQEEVYTHVGRTVLNNTVDGYNGCILAYGQTGTGKTYTMLGPRDVVTSGRLYREELAQQSSSFSSITKLKLCSPSPSCSGQMKGIDESAFLELSLGGDSFSTTEEGIIPRFARDLFNSLRQKQREDSSYSYRVEMEFYEIYNEKVFDLISGGHSTNDLRVRHQTVRGVFVEGLDRKPIAAEEDLLFWMYRGSIERHTASTKMNDRSSRSHAILSIHVVQMTLDENNNTNRVSSKLNLVDLAGSERIGASGVEGLHFKESTKINLSLTALGRVIDCLADASTGKPSAFCPYRESNLTWLLMDSLGGNSKTSMVATVSPCVEHYEVTCQTLRYASRAKQIVNVAVVNEDPQVRQIKKLTAEVSRLKQLLNNQSICDYSNEEVERLRQRVVQLQQEAVERDFMLETFREELNDKTSLMNHHRNGSVTLCKHNANGKQHQQGGETMTKDEVNSPHLMQRTKGKESTGGAATGDCGGKQSSRSVNPYLNARTLQQLKYLRIEADQDYGTLIATLARCAFDATMNYECTLQKNIMMINSHSHALRENVQKMESKEWLVLASIGDRLLSEFAKACGKHASTPRHHETVKPKGLKTPEVEVQDKDRDKARMEINRLRERLYDAMVENDGLKERCEALEKEAHNFSKMERTLKQKLATLQAELDGAGPKVIAWATNTMKAEPGLTPRTAVNTTRENHDCPKEGRRMSPLLPSARCVQARKVKHSPRQKEVGTTRRVAEKNGTEAQLENSVCSLSVPVLNLRQISAAAFLRSAIDSHHDALLDLLMDKFRLVGNLYEQYAKSFLGKNPLTGSNGKSECPEKELTLAEERLPSKKVPKRSVEVQKKSKVASDMISSRGRGRGGVLTGDDALCRESTVTLHSPRGAENAKGLQRRCHQKAQATTVRKTSRRTLGSSSDTFLPDCEEEVTFLKEQFTRRESGIKKEHQSVVRELQNNLAEAVKRAAQEYKQLLDQSSNEKKQLNEQLAKYGSIAAAAEKTKESVSEQTRLFREQCSGRTAIEIEQMEVWASTVASSVASIYRLRKEQESVAAAKERQQLINQAACDKAELTCSLRHRTEVLLEWVSGREVLLCEEERTRAHLVLRFREQGIASGCCAELSTMLVESHKLLTEHCVVEHQVFIEGVTPICNAFLGASNALAKEKSHVMQLQGQVRSAVMGQCRQQLLQCREDEISAREAILASQDSEAAVIKDALRRIGGAIVINQKFVTDLRNRLNTAQTEQHRHQLRGCLEYEANSRNTILAAQKDGVATIRFAFEQAHLALEQKQYQTTRLNAELDCSKNNNHLQGVRVCLDSETDARDHLVAYQQGEWQVLELCFNTGRKMLMDNARYLCGLLDTANTSLAAAVVRAPKSALGAVFLFEQHERFVLEELNAHTTCLQDAHRELSVLLSTSQVQRECDVTLTALENYYSEELARTEKENKELKANIQILRENLDFQASLDQLQAEIEGDGPAGLGSGGGSEGDPLSLTQHREGLGISGLISNFFTRVGYVRKDGLPRDFSPRMMMSHTSSEEDFGAMSDAAARFGYTPVKDGRNRRNSMQSIVGSALFPPNHDSTPLRDDDASIQ
Protein: Uncharacterized protein, isoform A (Uncharacterized protein, isoform B) (Q9VJ27)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- EG:BACR42I17.11 protein
Sequence:
MPAHCAVINCSHKYVHAGSISFHRFPFKRKDLLQKWKEFTQRSAQWMPSKWSALCSRHFGDEDFNCSNNRKTLKKNAVPSIRVSEDDSMSGHLEQVSPSNRPTHKQTLSSAAESAATGVKATCRFCGSSAINCSSFDKSFELFGMIQKCFPTLQILQDDTLPKEICQECCLQLERFSQFIDVVMLAQSELQRKYRRQLKIKQEPLVRVKQEACESLDNLFPDELDMGLEQDDGCDQEETEQKFQFCEFPMLNAQDIINNCDIMEIINLDDPFINIPDDADVGQSERLQPGRTANEMLQNELLTEEHNYAKEEWQLPPHQYKTEKVEGTDAAPDAAPPPADPPPLQDNIDPPSAPEPRSCKPIVTNVSQIPNPMICELLPQPAPPTSIKPNIVVLNDSVVESSAAFRLHNCTLCTAKFITIDSLNQHYAHSHSNSTPMVSVPPMNICLPSLTMNPPMKMESNRGLVATEQSEYWPLEWHNSPVSKQPRKKIDILDMQSSFLHHKDLIPTATQLSAPAPDPQLVAVTASYAKLANRYRKLQLKCKKLKSPRKVHRKTYVCRMCRKGFSKFKNLHHHRRQKAHFVKLIPNFSGRCSGCLKFFRSRLGLRQHMRYICQSLSLKNHRRLQSFKCRHCQAIAFAHWRLYRRHELNCRPKKSKTKVQTAMNSKKKVTPTQVFECNICKKSFGSLNGLRQHNITHSTERQHKCGICERVFKRRNGLSQHIKGYHLQLKPHECPVCQHRYALKCDMLRCRHSLRKGPAAGE