wanglab/gogpt-training-data huggingface dataset:
Protein: Bradykinin (P84825)
Organism: Ascaphus truei (Coastal tailed frog)
Function: Induces relaxation of mouse trachea that has been precontracted with methacholine. May induce relaxation of arterial smooth muscle. May target bradykinin receptors (BDKRB).
Subcellular location: Secreted {ECO:0000269|PubMed:15922344}.
Interaction partners:
Sequence:
RPPGFSPFR
Protein: Mitotic checkpoint protein BUB3.1 (Protein BUDDING UNINHIBITED BY BENZYMIDAZOL 3.1) (Q9LJN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20 (By similarity). Essential for gametophyte development.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, phragmoplast. Cytoplasm, cytoskeleton, spindle. Note=Accumulates onto both kinetochores and the spindle microtubules in cell arrested in metaphase. Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. Associates with unattached kinetochores upon spindle assembly checkpoint (SAC) activation. Present in the phragmoplast midline during the final step of cell division.
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Mitotic spindle checkpoint protein BUBR1
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Cell division cycle 20.5, cofactor of APC complex
- Anaphase-promoting complex subunit 4
- Cell division cycle 20.2, cofactor of APC complex
- Protein SUPPRESSOR OF FRI 4
- Cell division cycle 20.1, cofactor of APC complex
- Cell division cycle 20.4, cofactor of APC complex
- At5g05510
Sequence:
MTTVTPSAGRELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEFLHGGAVLDCCFHDDFSGFSVGADYKVRRIVFNVGKEDILGTHDKAVRCVEYSYAAGQVITGSWDKTVKCWDPRGASGPERTQVGTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQAKKYAFKCHRKSEAGRDIVYPVNSIAFHPIYGTFATGGCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSYTFEEGEKSQEPEAIFVRSVNEIEVKPKPKVYPNPAA
Protein: Solute carrier family 37 (Glucose-6-phosphate transporter), member 4 (Solute carrier family 37 (Glycerol-6-phosphate transporter), member 4, isoform CRA_a) (Q6IRK4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MAAQGYGYYRTVIFTAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVTAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE
Protein: Type-4 uracil-DNA glycosylase (EC 3.2.2.27) (stoUDG) (Q96YD0)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Function: Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP.
Interaction partners:
- Type-5 uracil-DNA glycosylase
- Oxidoreductase
- DNA primase large subunit PriL
Sequence:
MDSLEKIKEEVISCKKCKLWQFRTNAVPGEGYPKAEIMFVGEAPGENEDKEGRPFVGAAGKLLTQMIKEILGLERDQVFITNVVKCRPPNNRDPEEDEITACSPYLDRQIDIIMPKIIVTLGRHSTKYIFSKMGENFSSITKVRGKSYVWKYKEKEIIVFPTYHPAAALYNPNLRKILEEDFKKIRELAITPKRYTIDYFLGGKNRSWDKREKSDSNSGK
Protein: RAS p21 protein activator 1 (E9PYG6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Rho GTPase-activating protein 35
- Docking protein 2
- GTPase KRas
- GTPase HRas
- Docking protein 1
- GTPase NRas
- Ras GTPase-activating protein-binding protein 1
- Ras-related protein R-Ras
- Ephrin-A1
- Ephrin type-A receptor 2
Sequence:
MMAAEAGSEEGGPATAGPGGGAATGSSAYSAACRVKLPAALPVAAAPCPGLADADLVAALGGGAASGSGFLGTGPVAGVLGGAALTGSAAAGVAGAAAAGPAGDVAFTKGTLSLPAETLGPGGGFPPLPPPPQLPPLGSGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQGQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLAITELLQQKQNQYTKTNDIR
Protein: Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Q8BGV3)
Organism: Mus musculus (Mouse)
Function: May function as a growth factor receptor.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Claudin-7
Sequence:
MARGLDLAPLLLLLLAMATRFCTAQSNCTCPTNKMTVCDTNGPGGVCQCRAMGSQVLVDCSTLTSKCLLLKARMSARKSGRSLVMPSEHAILDNDGLYDPECDDKGRFKARQCNQTSVCWCVNSVGVRRTDKGDQSLRCDEVVRTHHILIELRHRPTDRAFNHSDLDSELRRLFQERYKLHPSFLSAVHYEEPTIQIELRQNASQKGLRDVDIADAAYYFERDIKGESLFMGRRGLDVQVRGEPLHVERTLIYYLDEKPPQFSMKRLTAGVIAVIAVVSVAVVAGVVVLVVTKRRKSGKYKKVELKELGEMRSEPSL
Protein: Signal transducer and activator of transcription 5A (Mammary gland factor) (Q62771)
Organism: Rattus norvegicus (Rat)
Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation (By similarity). {ECO:0000250}.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase
- Receptor protein-tyrosine kinase
- Signal transducer and activator of transcription 5B
- Cytokine-inducible SH2-containing protein
- Receptor tyrosine-protein kinase erbB-4
- Tyrosine-protein kinase
- Interleukin-2 receptor subunit alpha
- Interferon regulatory factor 9
Sequence:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFVLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFGQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELVEKHQKTLQLLRKQQTIILDDELIQWKRGQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNRRSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDLDETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARSSLS
Protein: AT19733p (Chromosome associated protein H2, isoform D) (Q8IHA6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDDKRFNAAGFVKCTRNRTIEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKMFTYHVEHRYNTLLPDIPFERLNLIKEYVHTNQVNTTEILNEHMTTKEYLDEYIALENQMLAARYGAIVTRRRRLVDSARFMEDNLDEGLAKKMCMDKNLPMDTNETVLIDQSLVDENSRSLTTAESTMGISQAENSTLKSSEVEATLSVSHIENSLSDSQEENPPLSSTLAINESSVLDSTRVDPIKDLTLDELLLIDSGISMEELSDIQMHTDLEDQRQLSPMLQMVSPSMEAKTLNIIEMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLPPEFDLFRQARLPIKREGQQKSPTTPRTVLQIGREAPQNEREPGSPCSLEFDEDLNFLGFRQRRPTFDSGFDIEEPRVSSCVSTIGEVKTELEDEIEANTNNLTDASASDALNENVNDTKESGLGDSLAQELNASTEPNAENNTANSSQLEVTATESSGTLSGLETTVDLGMESALVSSVLDLSTEPSAMDSNIINVTQPDNSDLEISTVQDQDTLHDEADANDLSAETPNPIADSAVDDCSLIRDWHRRLAPALEAAHERQNFNIKDLGTEILDICKAGNRTATLADVMADKDPSIMCRYMLASLVLTNHGNVSLDFENRDKSREINALSHAVQQDQEAALDICSCQIIYPQSCTNNKNRQMTF
Protein: Structural maintenance of chromosomes protein 4 (Q12267)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Interaction partners:
- Structural maintenance of chromosomes protein 2
- Condensin complex subunit 3
- Condensin complex subunit 1
- Condensin complex subunit 2
- Sister chromatid cohesion protein 1
- Cohesin subunit SCC3
- Kinetochore protein NDC80
- Structural maintenance of chromosomes protein 6
- Structural maintenance of chromosomes protein 5
- Structural maintenance of chromosomes protein 3
Sequence:
MSDSPLSKRQKRKSAQEPELSLDQGDAEEDSQVENRVNLSENTPEPDLPALEASYSKSYTPRKLVLSSGENRYAFSQPTNSTTTSLHVPNLQPPKTSSRGRDHKSYSQSPPRSPGRSPTRRLELLQLSPVKNSRVELQKIYDRHQSSSKQQSRLFINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDSMLFVFGFRANKMRQDRLSDLIHKSEAFPSLQSCSVAVHFQYVIDESSGTSRIDEEKPGLIITRKAFKNNSSKYYINEKESSYTEVTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLLEYLEDIIGTANYKPLIEERMGQIENLNEVCLEKENRFEIVDREKNSLESGKETALEFLEKEKQLTLLRSKLFQFKLLQSNSKLASTLEKISSSNKDLEDEKMKFQESLKKVDEIKAQRKEIKDRISSCSSKEKTLVLERRELEGTRVSLEERTKNLVSKMEKAEKTLKSTKHSISEAENMLEELRGQQTEHETEIKDLTQLLEKERSILDDIKLSLKDKTKNISAEIIRHEKELEPWDLQLQEKESQIQLAESELSLLEETQAKLKKNVETLEEKILAKKTHKQELQDLILDLKKKLNSLKDERSQGEKNFTSAHLKLKEMQKVLNAHRQRAMEARSSLSKAQNKSKVLTALSRLQKSGRINGFHGRLGDLGVIDDSFDVAISTACPRLDDVVVDTVECAQHCIDYLRKNKLGYARFILLDRLRQFNLQPISTPENVPRLFDLVKPKNPKFSNAFYSVLRDTLVAQNLKQANNVAYGKKRFRVVTVDGKLIDISGTMSGGGNHVAKGLMKLGTNQSDKVDDYTPEEVDKIERELSERENNFRVASDTVHEMEEELKKLRDHEPDLESQISKAEMEADSLASELTLAEQQVKEAEMAYVKAVSDKAQLNVVMKNLERLRGEYNDLQSETKTKKEKIKGLQDEIMKIGGIKLQMQNSKVESVCQKLDILVAKLKKVKSASKKSGGDVVKFQKLLQNSERDVELSSDELKVIEEQLKHTKLALAENDTNMNETLNLKVELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSEITQQEKGLNELSIRDVTHTLGMLDDNKMDSVKEDVKNNQELDQEYRSCETQDESEIKDAETSCDNYHPMNIDETSDEVSRGIPRLSEDELRELDVELIESKINELSYYVEETNVDIGVLEEYARRLAEFKRRKLDLNNAVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITMGGNAELELVDSLDPFSEGVTFSVMPPKKSWRNITNLSGGEKTLSSLALVFALHKYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAQQLVGVYKRDNRTKSTTIKNIDILNRT
Protein: Ethylene-responsive transcription factor ERF112 (P93007)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- non-specific serine/threonine protein kinase
- C2H2 and C2HC zinc fingers superfamily protein
- Trihelix transcription factor DF1
- C2H2 and C2HC zinc fingers superfamily protein
- C2H2 type zinc finger transcription factor family
- Nuclear transcription factor Y subunit C-5
- At1g60280
- Peroxidase 13
Sequence:
MHSGKRPLSPESMAGNREEKKELCCCSTLSESDVSDFVSELTGQPIPSSIDDQSSSLTLQEKSNSRQRNYRGVRQRPWGKWAAEIRDPNKAARVWLGTFDTAEEAALAYDKAAFEFRGHKAKLNFPEHIRVNPTQLYPSPATSHDRIIVTPPSPPPPIAPDILLDQYGHFQSRSSDSSANLSMNMLSSSSSSLNHQGLRPNLEDGENVKNISIHKRRK
Protein: Leucine-rich melanocyte differentiation-associated protein (Q9H2I8)
Organism: Homo sapiens (Human)
Function: Required for melanocyte differentiation.
Interaction partners:
- Small nuclear ribonucleoprotein E
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor SYF1
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D2
- U4/U6.U5 tri-snRNP-associated protein 1
- Splicing factor 3B subunit 3
- Small nuclear ribonucleoprotein G
- Splicing factor 3B subunit 1
- Pre-mRNA-processing-splicing factor 8
Sequence:
MEKYLSLSGNHSSNKRSLEGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVTPALEYLSLLGNVACPNELVSLEKDEEDYKRYRCFVLYKLPNLKFLDAQKVTRQEREEALVRGVFMKVVKPKASSEDVASSPERHYTPLPSASRELTSHQGVLGKCRYVYYGKNSEGNRFIRDDQL
Protein: Torsin-1A (Dystonia 1 protein) (Torsin ATPase 1) (EC 3.6.4.-) (Torsin family 1 member A) (Q9ER39)
Organism: Mus musculus (Mouse)
Function: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O14656}. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. {ECO:0000250}.
Interaction partners:
- Tumor necrosis factor receptor superfamily, member 25
- Torsin-1A-interacting protein 2
- Torsin-1A-interacting protein 1
- Protein-glutamine gamma-glutamyltransferase 2
- Torsin-1B
- Alpha-synuclein
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Sequence:
MKLGRAALALLLLAPCVVRAVEPISLSLALAGVLTTYISYPRLYCLFAECCGQMRSLSREALQKDLDNKLFGQHLAKKVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNITQYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWKSGKQREEIKLRDMEPALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEVDEDIISKVAEEMTFFPKEEKVFSDKGCKTVFTKLDYYLDD
Protein: Opsin 5 (D9N3D0)
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGAVVCSVRSVCLFVFSDTELDMSGMASDCNSSQEEYLPHHVQQEDPFASKLSREADIIAGFYLTVIGILSTLGNGYVIFMSSKRKKKLRPAEIMTVNLAVCDLGISVVGKPFSIISFFSHRWIFGWMGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLAYGTWLKRHHAFICLALIWAYATFWATVPFAGVGSYAPEPFGTSCTLDWWLAQASVAGQAFVLSILFFCLLFPTAVIVFSYVKIILKVKSSTKEVAHYDTRIQNSHILEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGQPDSVPIQFSVVPTLLAKSAAMYNPIIYQVIDCKFSCCRSGGLKTLQKKSSLKDSRMYTISSHRDSAALSETQLEV
Protein: Carbohydrate-binding domain-containing protein (Q55CG7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MKSISIIFSLFLIINLVFSADPTIVSFRKPVERVYPGEYCLPSFTVLVNYPDPIQYNYQLGLFDKSGGYGSNIPSAVNGTLYLFTLTHKVPIGKNQPVSLYIQDYSKNPWFTFDFNNYTTYDCDPLPPVTMKSKQNTWIRSSGQYTNLVWYHMVEVSGLDKSAPYDAFTCNVPEPFYCAFQEFLNGPKPINYYFQIAIRKSDVNFTPFNVTITDKQGKVLLNSLFDGLSAPANPPVSIRSLENYPINGSTVTKNEMVNDAMYIMNIINKNALCGISSPKDYFIGNTLIPVLGTPSNATYIGFSSFLYQNGPIESHVQIIDSQGTKRIGIDNVLLINPKSYDNVIENVQNATYVKSSNINKTLINIKADVSFNPKTSHTSSFLSSQRETVLDYPYGYSNGTIKYHSVSFSKTSPEYSTSSNSYMSINSPSDIGNGNSSLIEIATNSTIDSKIPQLLKVETVFLSYEKVLVRIFAKDVDSGISYLHSTNLHKISPADLVYGDNFNGVYETVETLATMYGNERPTVSIYDNAGNNIQYNSMQPTFDTSFNMIPEYPVYTMIKNQANLDPYTFTGFEFKYNDVDVSNGPFNNTLCMNFAGSNKTMTPRFLQLPLALNPEKASLDNATPGSWDEVKGMFCMDFQIPARIFTGEYTYAVLIPPFVYDSYYFAISVGSKAQLRVNSGFADQMPPIITEFSSYPSNAVNVTQDTVVGWNIRIEDSPNGLASGEFNITSDFDLEPYRIKITPANAVSGDIFSSTYQLRIPIKANTCRSQSFRISSASITDTMGHTSVLPSSGNVNPLYKFLESPHLVLNITCPQAIIDNTPPSLISFSTVSSIEVGAYKDFRNVTFTFKTSDSGSGISSRHNPKIYLSSGEFDQISKISTLVSNVNGVATYTCTIELPYGYGSYNGILVSIYGIVDNKLNINGYSSVDLQQLGFQNTIKVLYSDVPVLDYTSSIKSTESSLTIYGHKFGIDRSKVTLQVDYQNGQGWKNTTISFFSGIILMTDNITPTSTPFYVRVIVDGKISNQLLVVPIVVGDSPCSYEVIQSIVATWIDSEKYPYLQASITIKNTGTRPIKAFSFIIEKIAYGQIWGVDANGNNRYTLPSYNLIINPRDQYSFGYIIQGTTVADLKQVTYTCL
Protein: Protein shisa-9 (Cystine-knot AMPAR modulating protein of 44 kDa) (CKAMP44) (Q9CZN4)
Organism: Mus musculus (Mouse)
Function: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses.
Subcellular location: Cell projection, dendritic spine membrane {ECO:0000269|PubMed:20185686}; Single-pass type I membrane protein {ECO:0000269|PubMed:20185686}. Synapse {ECO:0000269|PubMed:20185686}.
Interaction partners:
- Glutamate receptor 1
- Voltage-dependent calcium channel gamma-2 subunit
- Glutamate receptor 4
- Protein cornichon homolog 2
- Glutamate receptor 2
- Voltage-dependent calcium channel gamma-8 subunit
- Disks large homolog 4
- Voltage-dependent calcium channel gamma-3 subunit
- Glutamate receptor 3
- Disks large homolog 3
Sequence:
MRRVLRLLLGCFLTELCARMCRAQERSGHGQLAQLGGVLLLTGGNRSGAASGEAGEGVGGSDAPPTRAPTPDSCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHRPQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDSRTPINNLHTTQMNNAVPTSPLLQQMGHPHSYPNLGQISNPYEQQPPGKELNKYASLKAVGNSDGDWAVATLKSPKADKVNDDFYAKRRHLAELAVKGNLPLHPVRVEDEPRAFSPEHGPAQQNGQKSRTNKMPPHPLAYNSTANFKTWDPSDQSLRRQAYGNKGKLGIAESGSCDPLGTRTQHFPPTQPYFITNSKTEVTV
Protein: Vacuolar protein sorting-associated protein 41 homolog (Protein light) (Q7PL76)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endosome membrane {ECO:0000255|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000255|PIRNR:PIRNR028921}. Late endosome membrane {ECO:0000255|PIRNR:PIRNR028921, ECO:0000269|PubMed:31194677}; Peripheral membrane protein {ECO:0000255|PIRNR:PIRNR028921}. Early endosome membrane {ECO:0000255|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000255|PIRNR:PIRNR028921}. Lysosome membrane {ECO:0000255|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000255|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network {ECO:0000255|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000255|PIRNR:PIRNR028921}. Note=Localizes to a subset of Rab7 positive late endosomes probably consisting of mature endosomes ready for fusion with lysosomes; this localization is dependent on Rab2 and Rab7 and a fully functional HOPS complex and prevented by Rab5. {ECO:0000269|PubMed:31194677}.
Interaction partners:
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Ras-related protein Rab7
- Vacuolar protein sorting 33B
- Vacuolar protein sorting-associated protein 33A
- LD27967p
- Vacuolar fusion protein MON1 homolog
- Vacuolar protein sorting-associated protein 8 homolog
Sequence:
MAKALPLISCDSWADSINEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPDSKAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCSLGLIKWEVPPQERLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLPVYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSSCFKALRPVLCVIEYKMNNSEEICTDSLTLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKKKIKTEIVVHQLEHNQEYLYWYLDSLLKKDPSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSEIVTTQRRGQQVSYEQLCSLCHRPVLMAGTHLYCIIRLECGHVYHKPCIQGELLKNCNECNLWKLTVGK
Protein: Taste receptor type 2 member 46 (T2R46) (Taste receptor type 2 member 54) (T2R54) (P59540)
Organism: Homo sapiens (Human)
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Guanine nucleotide-binding protein G
- Probable non-functional immunoglobulin heavy variable 3-16
- Taste receptor type 1 member 2
- Taste receptor type 1 member 1
- Taste receptor type 1 member 3
Sequence:
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS