wanglab/gogpt-training-data huggingface dataset:
Protein: Lipid A 1-phosphatase (EC 3.1.-.-) (Q9ZN40)
Organism: Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Function: Removes the 1-phosphate group from tetra- and probably hexaacylated lipid A species. Absence of the 1-phosphate group renders the bacteria partially resistant to host-derived cationic antimicrobial peptides (CAMP), allowing it to camouflage itself from the host innate immune response, and plays a role in the long-term colonization of the host's stomach.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:O24866}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKKFLFKQKFCESLPKSFSKTLLALSLGLILLGVFIPFPKVPKHQSVPLALHFTEHYARFIPTILSVAIPLIQRDAVGLFQVANASIATTFLTHATKRALNHVTINDQRLGERPYGGNFNMPSGHSSMVGLAVAFLMRRYSVKKYLWLLPLIPLTMLARIYLDMHTIGAVLAGLGTGMLCVGLFTSPKNLN
Protein: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) (Q22629)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}. Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Laminin-like protein epi-1
- Laminin subunit alpha lam-3
- Laminin-like protein lam-2
- Agrin
- Dystrophin-1
- Laminin subunit beta-1
- Dystrobrevin-1
- Nidogen
- Integrin alpha ina-1
- Basement membrane proteoglycan
Sequence:
MRLIFLVSTLLLVTTAISDTRVFIGELFEHNLGDNYTIATGKDSGPLPSWLMVRDQTLTGIPTENDVGRHTVMIKSRGRKPVYLYLNVEEETISPCGANNTFWMETYHEQEASLANRINTALAMNELELDPEIKTVRIYSFNFSLINRELEEINQEAVHGQYMAIWKVACEDFDEALNYMDDFVDREDVDYDSIKLAKGFFKPGMAPKPTKEAEDPTTAEYLRTTTELIRTTRRITDNKPILLNRLPSFTCTRGEMCDLRIPSETFKDAEDGDTFKMKLSVLALDNAEVWMINESNKGLIGVPMRTGEFNYRLEARDKAGQLASAPFQVNVKPALPTNHRVQLEMDQPTPQQMATNPSKRNLLVRALARSLKAPVNSFTIQEIGYKNNKTMVAFSNNSIPYKVCDEAAINAMASKMIIKQKMRTKTEFVKTMGNQFYVRTATMIRHGNCDETVEISTTAPTVESIQEADSQLLLICVLLFLLLLIAVAIIIYCACIKKSGKKKSTSTEYVSKGLPVVFPDEVEENDPTHAGTPMLAREERPPLKVSQHENPLYKPPPPIASNSPRLGHASSSSNQKLQSPFIPP
Protein: PAR-domain protein 1, isoform O (M9PBV3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSEPKENIMDLSVRGRKSPFLGFICKSNGKSTSNSKEIICPDDKYKEEGDIWNVEAQTAFLGPNLWDKTLPYDADLKVTQYADLDEFLSENNIPDGLPGTHLGHSSGLGHRSDSLGHAAGLSLGLGHITTKRERSPSPSDCISPDTLNPPSPAESTFSFASSGRDFDPRTRAFSDEELKPQPMIKKSRKQFVPDELKDDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKENATLHQEVEQLKQENMDLRARLSKFQDV
Protein: Coenzyme Q-binding protein COQ10 START domain-containing protein (Q8VKQ8)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTAISCSPRPRYASRMPVLSKTVEVTADAASIMAIVADIERYPEWNEGVKGAWVLARYDDGRPSQVRLDTAVQGIEGTYIHAVYYPGENQIQTVMQQGELFAKQEQLFSVVATGAASLLTVDMDVQVTMPVPEPMVKMLLNNVLEHLAENLKQRAEQLAAS
Protein: Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (F8VWV4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAFEQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPA
Protein: Mitochondrial distribution and morphology protein 12 (Mitochondrial inheritance component MDM12) (Q92328)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03104}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03104}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03104}. Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03104}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03104}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03104}. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03104}.
Interaction partners:
- Mitochondrial distribution and morphology protein 34
- Maintenance of mitochondrial morphology protein 1
- Mitochondrial distribution and morphology protein 10
- Mitochondrial Rho GTPase 1
- Mitochondrial import receptor subunit TOM7
- Dynamin-related protein DNM1
- Sorting assembly machinery 37 kDa subunit
- Sorting assembly machinery 35 kDa subunit
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM70
Sequence:
MSFDINWSTLESDNRLNDLIRKHLNSYLQNTQLPSYVSNLRVLDFDLGKVGPAITLKEITDPLDEFYDSIREEADQETEENNDNKEDSEHICPDRTIANHEGPKDDFEAPVVMPSPNDIQFLLEVEYKGDLLVTIGADLVLNYPVEKFMTLPVKLSISDIGLHSLCIVACLSKQLFLSFLCDVSDPALDDNQTVLDPKGPILAATKPLERISIVRSMKIETEIGEQYQGQGSVLRSVGELEQFLFTIFKDFLRKELAWPSWINLDFNDGDE
Protein: Probable transcriptional regulator YgiV (Q46866)
Organism: Escherichia coli (strain K12)
Function: Represses expression of mcbR.
Interaction partners:
- Protein YgiW
Sequence:
MTNLTLDVNIIDFPSIPVAMLPHRCSPELLNYSVAKFIMWRKETGLSPVNQSQTFGVAWDDPATTAPEAFRFDICGSVSEPIPDNRYGVSNGELTGGRYAVARHVGELDDISHTVWGIIRHWLPASGEKMRKAPILFHYTNLAEGVTEQRLETDVYVPLA
Protein: Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499 homolog) (Spot 14-related protein) (S14R) (Spot 14-R) (Q9CQ20)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules.
Subcellular location: Nucleus {ECO:0000269|PubMed:15070402}. Cytoplasm {ECO:0000269|PubMed:15070402, ECO:0000269|PubMed:20457939}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15070402}. Note=Associated with microtubules (PubMed:15070402).
Interaction partners:
- Thyroid hormone-inducible hepatic protein
- E3 ubiquitin-protein ligase Midline-1
Sequence:
MMQICDTYNQKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLSEPEIDEVSVEVGGSGGCLEERTTPAPSPGSANESFFAPSRDMYSHYVLLKSIRNDIEWGVLHQPSSPPAGSEESTWKPKDILVGLSHLESADAGEEDLEQQFHYHLRGLHTVLSKLTRKANILTNRYKQEIGFSNWGH
Protein: Fibroblast growth factor 17 (FGF-17) (P63075)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Klotho
- Fibroblast growth factor receptor 3
- Pro-epidermal growth factor
- Vascular endothelial growth factor receptor 2
- Beta-klotho
- Vascular endothelial growth factor receptor 3
- Decorin
Sequence:
MGAARLLPNLTLCLQLLILCCQTQGENHPSPNFNQYVRDQGAMTDQLSRRQIREYQLYSRTSGKHVQVTGRRISATAEDGNKFAKLIVETDTFGSRVRIKGAESEKYICMNKRGKLIGKPSGKSKDCVFTEIVLENNYTAFQNARHEGWFMAFTRQGRPRQASRSRQNQREAHFIKRLYQGQLPFPNHAERQKQFEFVGSAPTRRTKRTRRPQSQT
Protein: Voltage-dependent T-type calcium channel subunit alpha (Q5SUG3)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MDEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAVGVRAGLLSSPVARGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRWLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPEMLKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHEMPDSDSEAVYEFTQDAQHSDLRDPHRRRRPSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDTSGQLSCIQLPVNSQGGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHSELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGKSASGRLARTLRADDPPLDGDDGDDEGNLSKGERLRAWVRARLPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGPRPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTDLDP
Protein: Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (Q92769)
Organism: Homo sapiens (Human)
Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
Subcellular location: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:24970816, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000269|PubMed:24970816}.
Interaction partners:
- DNA
- Histone-lysine N-methyltransferase EZH2
- Paired amphipathic helix protein Sin3b
- Metastasis-associated protein MTA2
- Histone deacetylase 1
- Chromodomain-helicase-DNA-binding protein 4
- Chromodomain-helicase-DNA-binding protein 3
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Histone deacetylase complex subunit SAP30
- Histone-binding protein RBBP4
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
Protein: Synaptopodin 2-like a (Synaptopodin 2-like protein isoform X1) (F1RCC9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVAEEVIITLSGGAPWGFRLQGGIEHQKPLQVAKVRKRSKACRAGLREGDELMSINENSCGSLSHAQAMNLIDSMPGTLHIRVRRAPAGFQSVVLVARAPSPRIDKEYRAALRAMSPSSSRPHQSSVRQIHRGTLMSPTGRSGLTSPPGSEAYYGETDSDADVAAHERHRKPKRRSPSNSPGKAGRASPEGAETSEMSGYDSASDAQMYKLLGPNKREDTLPGVARREVIYQPPLHGAWSSQTSTETSSMSADDQNPREGLMEEDSGFQEPTNIPPLVSPERAKEALMLSSRSQLVPMVGPVDNPVDEELTLTYMDKAKQAKLNRGETITDKQVKEARSKCRTIASLLTDAPNPHSKGVLMFKKRRQRSKKYTLTSFGSVDEDMRQDSQEEDGIFPGSESEFDEEGFSAAPDPTWDSDYLEMLEKRCASRGQEGDGGALSPGLSDTSGKGAQLFEQQRKRAEEHARKIEAAQEQLQSQMLGISLKEAQALPPLQTAHPDPLTKLNVQPPPVAPKPARPSTTLYHDVQAAEAQNNKTQMNTPQTIPTVPVMVNGDASNTTVTAPSVMPKTNLSVLSTETVMPPPPTPLPELPASSVLNRTARPFAPGCITNRAATAPVVFRPAVSKKTPRPVSVAVVAPPFPAASEEHVMCVTPAIFGTQVTMSQMNANVSNEIIPTQPLAQGTSIPPPAAVSVESYSQPAFQCSAMESIQVASLPRVQAQKPTVPMIAETIVPPDDMVTSLATDMHPKGITISSQTSSILTPTASETTSSPVIPLSPVVYREKPASVGGRTGILQDARRRSAYKPMFKMPDSKKNSPNPELLTMVQNLDDRPSHGYPEPDNIVYNIDENRTRVPPPVAPKPRVIPEMSQIPQAEGKGAELFARRQSRMDQFVVDTPYLQPATLQHQQSQSVIDFIQPREPSPTPSQWKYSPNVRAPPPIGYNPLLSPSCPVGVQRAGAKVSEGSAKGSKGSYGVPKEGIKALDFMRRQPYQLNPAMFSFGGGIGTQSSIPSYQRQQREGHTLTPPKQIPVKAARVYEIKRFSTPTPMSAPTLNPTVIIPRSQTTLGERISRSDMTSPAPEPVPESSLAPSRAPGLPELPKISSVPIPHPMPYSPPVPISSMSNLSYSGLQAAKQFKSAPELSALPPNPLKSPIQVPKPHFIATRAGVQPRVWRPGTLPH
Protein: Putative uncharacterized protein IRX2-DT (Coordinated expression to IRXA2 protein) (IRX2 divergent transcript) (Protein CEI) (Q86SI9)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MVAPAARVFLRAVRAALTSTVPDLLCLLARGSPRGLASGRLPLAVHSAQHGPGSGAPWLRIARRALRFVLSKHWGDDCYLTNRLWQDLKPPSHVENGQELRLAPPVQWALQVQGNQLQTAVLCLRMAPPEPAGSRQRI
Protein: GH01133p (Ras association domain family member 8) (Q9VBP2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform B
- FI07216p
- LD40758p
- Meru, isoform A
Sequence:
MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLKWGEYANDVQFILQRSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLGPNNNNNNKPAPTLLKQKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQLQSQQTAMGAPASPPQEQLTPQDNNNVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYNDFYNNNSSSNQHIYSQLSKSSNELRRSSPNEMYYNNNNNIVNNNNNSPELYKQTPTISANGALVPPPYRDPPPPRNSPMCQGQRLASSNADTMSNASSSTNPFLSDYDQHSSHNTNSINNNSQAMEEGEPMFQTTQYNDLLQLIKFQREKITAQQMELQKFDTEIVYLESKERDHAHELDAISREISKADQIFRQGSEQLQTLQYVEEENELVKQQEKTLKSEIALLRSKLANCETELLQCKNKMRLLMDDIELEQQHQQQTNRQTVERDFLMEMERIQSEIDQALHNTDTSNKTADSLKKELLMIEHAIADKKRQVEQLVNEMKEVNLQSLTVTTTEEIKHLLEGPNKQGSSRRIIGSPRQLETAVPTSKNPHGVWV
Protein: Linear element-associated protein hop1 (Meiosis-specific protein hop1) (Q9P7P2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Facilitates initiation of meiotic recombination and DNA double-strand break (DSB) formation at DSB hotspot sites by enhancing the interaction between rec10 and rec15.
Subcellular location: Nucleus {ECO:0000269|PubMed:15226405, ECO:0000269|PubMed:16532353, ECO:0000269|PubMed:31665745, ECO:0000269|PubMed:33825974}. Chromosome {ECO:0000269|PubMed:15226405, ECO:0000269|PubMed:16532353, ECO:0000269|PubMed:31665745}. Note=Predominantly localizes to linear elements (LinEs) on meiotic chromosomes, the S.pombe equivalents of synaptonemal complexes. A proportion also localizes to DNA double-strand break (DSB) hotspots. {ECO:0000269|PubMed:15226405, ECO:0000269|PubMed:16532353, ECO:0000269|PubMed:31665745}.
Interaction partners:
- Linear element protein rec10
- Meiosis-specific serine/threonine-protein kinase mek1
- Linear element protein rec25
- Linear element protein rec27
- NURS complex subunit red1
- Linear element protein Mug20
- Meiotic recombination protein rec7
- Meiotic recombination protein rec12
- Meiotic recombination protein rec24
Sequence:
MNSYKEEILQTKSDFTLKNLIFFAISTLCYKRALFNENCYKKVNFEIEHFKGADFDCQLKPTVVSLQAGVDKEADSFLEMMKTYIFSLVSMKVPFTVYLIISSQCKSILEDDAVEKEIFSFTINPGSEEKICCESFVSYQRSERFVIKLFLSGNVKTECKDEEKVVQIITKMERFQLSKGEATKAGVFLNTVETKDCMSWLNRGEFKDIVSFYESNNGIAISHCSHAFVPISTEKIMINKESSLFDSQEKIDSQLEKFLQPLKYDEIGSTQILDEQSVEKSLSQGKCEKMQNESRGLREIKNNNPCEEVKKSNWLKKNISGSDKVDKAEKKKALLNCECGDSTEDSEMFQCERCDGWVHCACYGFESDSDPRQPNQLLCYTCLLVDSESSLYDRMTMLVAYRRAIRCIWASEYQGFQKLAARLNCSYADAKRIEERLVNENIIYKEKKRKWIYFTNKSPEMVSYLREKYFTPSRWISHLNFQNYRQENQRVNMRSFLRPERMEVIERPKKVSKTSNTKETDTMKPLRI
Protein: Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2) (Q76I89)
Organism: Gallus gallus (Chicken)
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O14777}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O14777}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000250|UniProtKB:O14777}.
Interaction partners:
- Uncharacterized protein.
- Uncharacterized protein.
- Kinetochore protein Nuf2
- BUB1 mitotic checkpoint serine/threonine kinase
- BUB1 N-terminal domain-containing protein.
- TTK protein kinase.
- Cytoskeleton associated protein 5
- Dsn1 protein
- Kinesin motor domain-containing protein
- Centromere protein E
Sequence:
MRRSSTTSGSSGRQSTMVLRVQDSNKMGLQTPQTKDRGTFGKLSMSKTTSATSERKVSFFGKRASGAGGSRNSQYGMFGTEKIKDPRPLHDKAFIQQCIKQLCEFLVENGYAHNVTIKSLQSPSVKDFIKIFTFIYGFLCPSYELPDSKFEEEIPRVFKELGYPFPLSKSSMYTVGAPHTWPQIVAALIWLTDCFKLYAAMRENPSSFDDGQNWGGETDDGIVHNKLFMDYVVKCYEHFMKGGDTYEELDAEVQSKLKDLFNVDEFKIEGLAAENKRLHEEIARLEKERESEPDRLVSLRKLRSSFQADVQKYQAYLANLESHTTILDQKMKSVNEEVETTEMEVEAMKQENARLQHIFDNQKYSVADIERINHERNELQQTINKLTKELEAEEHQLWNEELKYARNKEAIETQLAEYHKLARKLKLIPISAENSKGHDFEIHFNPEAGPNCLVKYRTQIKAPLMEIVNQTEEEIRKATQRKMSLEDTLEQVNAMVAEKKSSVKTLKEEAEKLDDLYHQKLKEAEEEEQKCANELELLEKHKQLLESGVNEGLSEATNELHDIQRQYQIVMQTTTEESRKAGDNLNRLLEVITTHVVSIEKYLDEQNSKIDRDYEEFMSEDLLSTLTGILDSYKKKAESI
Protein: DNA-directed RNA polymerase subunit p47 (P34051)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Component of the viral DNA-dependent RNA polymerase which is composed of four equimolar subunits of LEF-4, LEF-8, LEF-9, and p47. Plays an essential role in late and very late gene expression.
Subcellular location: Host nucleus {ECO:0000269|PubMed:8474157}.
Interaction partners:
Sequence:
MFVTRLEHTTQFLPQACKLEDEVLVLYAIYLNGFDYTLPRFVKREVQVNADGFVRFDYNIKMFDFARFTDMTQTTPEDIDDYINLTRINSLSDHDLKMLQLVCRDRWYKGDVARLRRILQQKDVDDLVKFVCNVMWERAYEDHYTLGQQLSIRITTKLIQSGLDFKHQPDTTAPVSVRGWEDATFEKYLQSITSISEVIKRHVFSKKYICLEVAASYWSDAVESLQQENFRIILNSKTPYVLLIEMDDDKNSMVYLRKLAHLLENKIVNLLFVTDVEFYFKNGNFMFYLYNSLKFYYYCLKNKFAFENVDKEIFFLLYTIVALEWFNGGHLNSFTLEKSALYNPLELSTRRLNSIKRAAQHNRVINCDSEINMDYIRGKRVRTGAHYGKRVVNFDLNQSLH
Protein: GH09946p (Q7K024)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
PPKVPNIQSELSEATMMSGQPLGSRVWLLSGVLLVTFAGTDAYGFGRCPNYPSMPKFNMSRVLGHWYEVERSFYLPEIASGCTTFQFEPYNKGEQSKFSNFKLAVAIKNINRITGNPNVNIGYATPENSRSSIMDFKFTTRFPDVIARLLPGSGKYQVLYTDYENFAILWSCGSIGSLGHSDQIWILGRDRDFEVDIRSKVYDVLKRLSLDPERLIISKNKQCPEAL
Protein: Delayed-rectifier potassium channel regulatory subunit KCNS2 (Delayed-rectifier K(+) channel alpha subunit 2) (Delayed-rectifier potassium channel subunit Kv9.2) (Potassium voltage-gated channel subfamily S member 2) (O35174)
Organism: Mus musculus (Mouse)
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
Subcellular location: Cell membrane {ECO:0000305|PubMed:9305895}; Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:9305895). {ECO:0000269|PubMed:9305895}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Potassium voltage-gated channel subfamily B member 1
- Delayed-rectifier potassium channel regulatory subunit KCNS1
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-3
Sequence:
MTRQSLWDVSDTDVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLDDSLH
Protein: BRCT domain-containing protein (Q20129)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein hsr-9
- Cell cycle checkpoint protein hpr-9
- Helicase ATP-binding domain-containing protein
- Serine/threonine-protein kinase ATR
- DNA replication licensing factor mcm-5
- PAX-interacting protein 1
- DNA replication licensing factor MCM3
- DNA replication complex GINS protein PSF3
- DNA polymerase epsilon catalytic subunit
- Homolog of S. Pombe Rad
Sequence:
MEAPPAPKKARRSEVSRMQDESVLCDDDEEDSPFTLYFVDLPNEPTVKEIRNLEELFKTAKAVGIMPEWIDSDALEDLQKSEDFFVLPCFRGKLFRKLQARKLKVYGPPIVLESIEDGKQLPQWNHPVYSSVFQDVKISFTGLNLTKKQELYEKIGWMCGVVGDALYHETTHLVTEKAEQTEKYKAAVNNSIKLMRIGWIDDLWETSQTTMGRFSALSRDSVNSYALRVFEGLEMAITSIDGADRTNFIQLIEDHGGKVPGTMSKTRCSYLISDKITGVKYAKAVEWKSMQIVQSRWIRKCVDLGHLVDAGKYHPKYLTADHIRSSTPKRDANVTESVPDISSIAGHGGRLGTSSFNSSIPQMDQSYQHQSGSSFISFASTSKIPSSTFTNNDSTLGRSGSGVRDGISTPIARVQTTPLIRYPTTQTASVQNIADVISDPIDELRKNIDDGLGDLFENCMFYICGVDESRMEKWRRFLNETGATRVAKFTSATNVVVVSPNQQERITIRKHLHQEDIAIVTVGWVVECVKQRKMISVEGYQWTENTADESQSSQSQLQPVRPQPLPRTSSKSTIPYGKTSGPSSTSTQVGIFSYHTYCVHCSVDQEVSDDLKEKIPLNGGKLMDDPDYAEFVIFGHSGPMHELISFDAVVTDFYIYASIGNNRFLNRSCYPLFVPLPRPPILIFNQRGFQLKCKDPFLRDRVRDIIEDNGGRIVEQLEPKDFIIMIDAEDNPPRYHSRTLDFSWIIASVSRCRLQPIDNFLYKNNTRPLSGFQRDDDLWEKCSREKNNSTQEMEVEVEDRHRVQDLPVETGNGNIGDMTTPYVNPYFPDLRKPYTMNLQLDGVSEYINNMESPARETQETLTTSRVGSILRKAVVNTGRNEDFEDEPSTCHLIRPRVPENRKTVSSTPVLVRDVNRSMRYMPMDESFADQNQEHEDLNRRYAMNPRFLLSVSNMDPQRAADLQETIMKLGGTIEREFNKDVTHLIASNMQRAPKVLCSIAAGKWCLTPDYVTKSAEVGRWLDEKSFEWTREKLLACSKKNESLKERDSRKVSENLAAVCGLWRQRVAEMPVTFSVSMENRQNGAFSDWRCVIHLDDKRAGVFSSILEAGGAIVHSISEYVEVSTLKPNIVLASKEFPWNPQSAVLLKRDNIPIYVFDILYDFLIDRDNLNRTKFWHNVYMKA