wanglab/gogpt-training-data huggingface dataset:
Protein: DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Endoplasmic reticulum DnaJ-PDI fusion protein 1) (J domain-containing protein disulfide isomerase-like protein) (J domain-containing PDI-like protein) (JPDI) (Q9DC23)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12446677}.
Interaction partners:
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Endoplasmic reticulum chaperone BiP
- Endoplasmin
- Hypoxia up-regulated protein 1
- Protein disulfide-isomerase A4
- Protein sel-1 homolog 1
- Protein disulfide-isomerase
- Peptidyl-prolyl cis-trans isomerase B
- DnaJ homolog subfamily B member 11
- Stromal cell-derived factor 2-like protein 1
Sequence:
MGVWLNKDDFIRDLKRISLCLLILYVVVVVGTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGDRSKESLVAFAMQHVRSTVTELSTGNFVNAIETAFAAGVGWLITFCSKGEDCLTSQTRLRLSGMLDGLVNVGWVDCDAQDSLCKSLDTTASTTAYFPPGATLNDREKSSVLFLNSLDAKEIYMEIIHNLPDFELLSANQLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSIHEYEGHHSAEQILEFIEDLRNPSVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKLYQYERAKKSIWEEQINSRDAKTIAALIYGKLETLQSQVKRNKDEL
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (A3KGU1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Axin-1
- E3 ubiquitin-protein ligase rnf146
- Axin-2
- Catenin beta-1
- Telomeric repeat-binding factor
- Hypoxia-inducible factor 1-alpha inhibitor
- Poly [ADP-ribose] polymerase.
Sequence:
MAVSRRSSQHQQSSLQPSPRNAVIASPPPESPSAIIPDSASLLSPSATGAAECGASTMESAAASSASASSPDRPAPVTAAAAGGPSVLGSSSCSSISSSATAGSQSPGSGAASPGEAVCGAGGAFRELFEACRNGDVSRVKRLVDSVNVNAKDMAGRKSTPLHFAAGFGRKDVVEHLLQTGANVHSRDDGGLIPLHNACSFGHAEVVSLLLCSGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKTVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQYGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLLNCHGKSAVDVAPTPELKERLTYEFKGHSLLQAAREADMAKVKKTAQEIISFKHPHSHDSALHCAVASPHPKRKQVTELLLRKGANIHEKNKDFMTPFHVAAERGHNDVLEVLQKHGAKVNAADTLGQTALHRAALAGHIQTCRLLLSYGADPSIVSLQGFTASQMGNEAVQQILNENVPPRNSDVDYRLLEAAKAGDLDTVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVAVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPSKKNRDGNMALDMVKDGDTDIQDLLRGDAALLDAAKKGCLARVQKLCSPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKFNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGANPTMKNQEGQTALDLATADDIRALLMDAMPPDALPSCFKPQATVLSAALISPASTPSCLSAASSIDNLAGPLCDGASGGAAGPADGASSTDRKEGDAVLDMNISQFLKSLGLEHLRDIFEREQITLDVLADMGHEELKEIGINAYGHRHKLIKGIERLLGGQQGANPYLTFHCTNQGTVLIDLAVDDKEFQSVEEEMQSTIREHRDGGNAGGVFSRYNVIKIQKVVNKKLRERYTHRQKEIADENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYLCHRQMLFCRVTLGKSFLQFSAMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPDSTPQSSTGAEQKS
Protein: Leucine-rich repeat neuronal protein 3 (Neuronal leucine-rich repeat protein 3) (NLRR-3) (Q8CBC6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- AP-3 complex subunit sigma-1
- Vacuolar protein sorting-associated protein 33A
- AP-2 complex subunit alpha-2
- SH3-containing GRB2-like protein 3-interacting protein 1
- BTB domain containing 8
- Sodium channel and clathrin linker 1
- AP-2 complex subunit beta
- AP2-associated protein kinase 1
- Synaptojanin-1
- Potassium voltage-gated channel subfamily KQT member 5
Sequence:
MKDTPLQVHVLLGLAITTLVQAIDKKVDCPQLCTCEIRPWFTPRSIYMEASTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSQWFDALPNLEILMLGDNPIIRIKDMNFQPLVKLRSLVIAGINLTEIPDDALAGLENLESISFYDNRLSKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNTNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWINMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSDLDVEADSYVSLHCRATAEPQPEIYWITPSGKKLLPNTMREKFYVHSEGTLEIRGITPKEGGLYTCIATNLVGADLKSIMIKVGGSVPQDNNGSLNIKIRDIRANSVLVSWKASSKILKSSVKWTAFVKTEDSHAAQSARIPFDVKVYNLTHLKPSTEYKICIDIPTVYQKSRKQCVNVTTKSLEHDGKEYGKNHTVFVACVGGLLGIIGVMCLFSCVSQEGSSEGEHSYAVNHCHKPALAFSELYPPLINLWESSKEKRATLEVKATAIGVPTNMS
Protein: Tlo9p (Q59KS8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Cta24p
- Tlo1p
- Cta2p
- Cta26p
- Tlo10p
- Tlo13p
- Tlo34p
Sequence:
MPENLQTRLHNSLDEILKSSGYIFEVIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKEEAARKKREEEAKKAEEIKKAEEAKKAEAAKKAEAAKKAETAPQKFDDFDDFIGFDINGNTNGEDMLSNMDYEDLKLDDKVHATTDNNLDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFGN
Protein: Nonsense-mediated decay protein 4 (Q12129)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent helicase NAM7
- Uncharacterized protein YLR363W-A
- Nonsense-mediated mRNA decay protein 2
- EST/SMG-like protein 2
- Nonsense-mediated mRNA decay factor EBS1
- Nonsense-mediated mRNA decay protein 3
- Transcriptional protein SWT1
Sequence:
MTQYNFIIDASAFEKGLGNIKRWCSDCTEAVTLNFYIPTFTLNELDFLQQRRKSFAARESLKFIDRLDDSKFANLKVFIEFPEVLDIILWSDVMEHNDSSGKINIAKLPKRLKNLLKSCIYKCYLEGNEGLHWFLISEDPQIREMAMQCNIPSCSIVDVDSILSKDMNDKSFRESEKFNNMMLKNGTKEESENGREIIRTNFNKTVYASRGTGELWSP
Protein: G protein-coupled receptor class C group 5 member A (A0A3B3ITN8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQVSDFFLPLHQRH
Protein: Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) (Q6P978)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03204}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03204}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Acyl-CoA 6-desaturase
- Very-long-chain 3-oxoacyl-CoA reductase-A
- Very-long-chain 3-oxoacyl-CoA reductase-B
- 20beta-hydroxysteroid dehydrogenase type 2
Sequence:
METVVHLMNDSVEFYKWSLTIADKRVEKWPMMSSPLPTLGISVLYLLFLWAGPLYMQNREPFQLRKTLIVYNFSMVLLNFYICKELLLGSRAAGYSYLCQPVNYSNDVNEVRIASALWWYYISKGVEFLDTVFFIMRKKFNQVSFLHVYHHCTMFILWWIGIKWVPGGQSFFGATINSGIHVLMYGYYGLAAFGPKIQKYLWWKKYLTIIQMIQFHVTIGHAAHSLYTGCPFPAWMQWALIGYAVTFIILFANFYYQTYRRQPRLKTAKSAVNGVSMSTNGTSKTAEVTENGKKQKKGKGKHD
Protein: Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) (Q96FL8)
Organism: Homo sapiens (Human)
Function: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively. Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16641166, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16330770}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). {ECO:0000269|PubMed:16330770}.
Interaction partners:
- Solute carrier family 22 member 2
- Solute carrier family 22 member 1
- Organic anion transporter 3
- Organic anion transporter 7
- Solute carrier organic anion transporter family member 1B3
- Solute carrier organic anion transporter family member 1B1
- Solute carrier family 22 member 11
- Solute carrier family 22 member 6
- Broad substrate specificity ATP-binding cassette transporter ABCG2
- Solute carrier family 22 member 7
Sequence:
MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
Protein: Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) (P62318)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
Interaction partners:
- U4/U6 small nuclear ribonucleoprotein Prp3
- Small nuclear ribonucleoprotein G
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm5
- Splicing factor 3A subunit 2
- Pre-mRNA-processing-splicing factor 8
- U6 snRNA-associated Sm-like protein LSm4
- Crooked neck-like protein 1
- U2 small nuclear ribonucleoprotein A'
Sequence:
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR
Protein: Uncharacterized protein (Q57V61)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small ubiquitin protein, putative
- SUMO-conjugating enzyme UBC9
Sequence:
MRFIYAKTVRLMPHRKLLQEIRSMSSAASVEAERSQLVSLLKSECSRSPPSLHDLCKVSMLCGAFCRRLATLDTIAASDVAKHAESLSSSINCSAPSAQVPLFAYALGEVEGLRNTRRLRYRQRLDDLTKGVPASRWDTEHITRCITELSLFEKLPARRRNDQGPPKRVCGESDIGGGSGPVAVRCQLPLRDPISLSVIATPARGVLCQHHEVFDLSAFVRTVQLVAVRRGESVDGALIQRWGTGGVGAGLGSSSDSDSSPAANCPFCGKYTSLQNVRVDEALAEAMARYSGNGGVLSVDCVVVWDMQSGSYNVMEKQAEVRPVCVKMEGDVMMEAEQRRGESPLGR
Protein: Testis-specific H1 histone (Haploid germ cell-specific nuclear protein 1) (Histone H1.7) (Histone H1t2) (Q8CJI4)
Organism: Mus musculus (Mouse)
Function: Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.
Subcellular location: Nucleus {ECO:0000269|PubMed:15710904, ECO:0000269|PubMed:16055721}. Chromosome {ECO:0000269|PubMed:15710904, ECO:0000269|PubMed:16055721}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000269|PubMed:15710904}.
Interaction partners:
- Histone H1.9
- Histone H1.8
- H1 histone family, member X
- Histone H1t
- Histone H1.5
- Histone H2A-Bbd type 1
- Nuclear transition protein 2
- Spermatid nuclear transition protein 1
- Histone H2A
Sequence:
MAEAVQPSGESQGAELTIQIQQPAERALRTPAKRGTQSVLRVSQLLLRAIAGHQHLTLDALKKELGNAGYEVRREISSHHEGKSTRLEKGTLLRVSGSDAAGYFRVWKISKPREKAGQSRLTLGSHSSGKTVLKSPRPLRPRSRRKAAKKAREVWRRKARALKARSRRVRTRSTSGARSRTRSRASSRATSRATSRARSRARSRAQSSARSSARSSAKSSAKSSTRSSAKSWARSKARSRARSRAKDLVRSKAREQAQAREQARARAREQAHARARTQDWVRAKAQEFVSAKEQQYVRAKEQERAKAREQVRIGARDEARIKAKDYNRVRPTKEDTSPRPAEEKSSNSKLREEKGQEPERPVKQTIQKPALDNAPSIQGKACTKSFTKSGQPGDTESP
Protein: RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (RNA-binding motif protein 9) (RNA-binding protein 9) (B0QYY7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSDSMDQPRNPCENEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEG
Protein: Acylaminoacyl-peptide hydrolase (H7C393)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
QVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGQYRTVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTGPGEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVAEKKRPKAESFFQTKALDVSASDDEIARLKKPDQAIKAFWAPGDAGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLIGGKCELLSDDSLAVSSPRLSPDQCRIVYLQYPSLIPHHQCSQLCL
Protein: Small ribosomal subunit protein uS2A (40S ribosomal protein S0-A) (Q9Y7L8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03015, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS17B
- Small ribosomal subunit protein uS10
- Elongation factor 3
- Large ribosomal subunit protein uL5B
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS9B
- Small ribosomal subunit protein uS4B
Sequence:
MAQVGRPNILNATDEDIKQLLAANCHIGSKNLEVRMDNYVWKRRSDGVHILNLGKTWEKLVLAARVIATIENPADVCVVSTRTYGHRAVLKFAAHTGATAIAGRFTPGNFTNYITRTYREPRLIVVTDPRADAQAIKEASFVNIPVIALCDTDSILNHVDIAIPTNNKGRKSIGLIWYLLAREVLRVRGTLSRSAPWDVMPDLYFYRDPEEVEREEEAKKAAAAAAEEAQVEEAVAAAEFEITDSAAGSVDPNVLAAATAGQVGENTWEGAGDWNTTGAAQTSDWTAAAEAQ
Protein: Transcriptional regulator SlyA (E0SG24)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
Sequence:
MELPLGSDLARLVRVWRALIDHRLKPLELTQTHWVTLHNIHQLPPGQSQIQLAKAIGIEQPSLVRTLDQLEDKGLITRHICAHDRRAKRILLTDMADPIIQAVNDVIDQTRSEILNGITPAEVDELATIISRLEKNILALHESQS
Protein: ADAMTS5 (Q6TY19)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLLEWASLLLLLLLLCASCLALAADNPAAAPAQDKTRQPRAAAAAAQPDQRQWEETQERGHPQPLARQRRSSGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDTVGAAGGIVTAGGGLSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAESERVYGDGSSRILHVYTREGFSFEALPPRTSCETPASPSGPQESPSVHSSSRRRTELAPQLLDHSAFSPAGNAGPQTWWRRRRRSISRARQVELLLVADSSMAKMYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLTDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDVPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSVIPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIIGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKTTQKVNSVISHSSNKVGLHSPQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCILSQRPSAFKQCLLKKC
Protein: HTH-type transcriptional repressor ComR (Copper outer membrane regulator) (P75952)
Organism: Escherichia coli (strain K12)
Function: Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.
Interaction partners:
- Multiple stress resistance protein BhsA
Sequence:
MATDSTQCVKKSRGRPKVFDRDAALDKAMKLFWQHGYEATSLADLVEATGAKAPTLYAEFTNKEGLFRAVLDRYIDRFAAKHEAQLFCEEKSVESALADYFAAIANCFTSKDTPAGCFMINNCTTLSPDSGDIANTLKSRHAMQERTLQQFLCQRQARGEIPPHCDVTHLAEFLNCIIQGMSISAREGASLEKLMQIAGTTLRLWPELVK
Protein: Transcription factor MYB12 (Myb-related protein 12) (AtMYB12) (Protein PRODUCTION OF FLAVONOL GLYCOSIDES 1) (O22264)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis mainly in the root. Confers tolerance to UV-B.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Flavonol synthase/flavanone 3-hydroxylase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Chalcone synthase
- Flavonoid 3'-monooxygenase
- Dihydroflavonol 4-reductase
- Transcription factor TT8
- Transcription factor EGL1
- Probable flavonol synthase 4
- Probable flavonol synthase 5
- Flavonol synthase 3
Sequence:
MGRAPCCEKVGIKRGRWTAEEDQILSNYIQSNGEGSWRSLPKNAGLKRCGKSCRLRWINYLRSDLKRGNITPEEEELVVKLHSTLGNRWSLIAGHLPGRTDNEIKNYWNSHLSRKLHNFIRKPSISQDVSAVIMTNASSAPPPPQAKRRLGRTSRSAMKPKIHRTKTRKTKKTSAPPEPNADVAGADKEALMVESSGAEAELGRPCDYYGDDCNKNLMSINGDNGVLTFDDDIIDLLLDESDPGHLYTNTTCGGDGELHNIRDSEGARGFSDTWNQGNLDCLLQSCPSVESFLNYDHQVNDASTDEFIDWDCVWQEGSDNNLWHEKENPDSMVSWLLDGDDEATIGNSNCENFGEPLDHDDESALVAWLLS
Protein: SET domain-containing protein (Q38D80)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone H3 variant
- Histone H3, putative
- NAD-dependent protein deacylase SIR2rp3
Sequence:
MDVHSPLRCAPARRSLKFPVGEQSRNFLAFDPSISKHDRMIFHMGVLAHAESLIDSDILPCFTVPVYLPGNYTELRVITDRRHPAFGQIGLFAKRTIPANFVVTPYSGYVEIFGTSCSSRTYTMGYGSLSDDYALDAEFAGNYGRFANDPRGMEGVTANISAESRFTARGETYTALVSRRIINKGEEILMSYGKAHNLTHSPWTGIKGELLTRYRVRSPMPFQFRGVTRLEGKYNDSNISVDNRGGNSRIVGVLSANSLQPCCSNQNRVTSGGVTERSRSGSGQPSTSTSDTDVELFWECPQCGMWSIRNFPTPQVDFCPYCRSPRVYRTRLVAVCCRAPLPQEVLTGPTLPTEPVASQRETISSTDAQNIADGTVGSSPEANSHCSHLSMQSKDIHNEDNIRGSQSKSSSGSGSTQASSTTLFTSHPINWPLNVPFLPWQVWDAAVPLTTIGRHSKFDTHNDIFLYTVNTLAEQEADQPLSDEMHQSDNNCGGSSSQNERNEDDEDGAEEEPHETRGKKRPRRGRQPRVRRKKEELWVKEDQNISDPHVPGKYDIAKRCGTVGSSPAAERGFCTDYFFLLSDSLICSGSGDDDANALRAVRSLLSDVTRRVFAGKTYRSGDVVASVGGLIQLVHDTRRRPDGSVMRIPMKYFIPKRVRDELSSNHKGVGAEAAVERMALVDLLRLFESLALVVTNELMFCPCIALPDRGDCGSTSTSVITFSGSEVGANARDPSLTSQRVLELCNLQFVLTVDALGCPYIAAVATKDINTFDPFLARIG
Protein: Protein slit (dSlit) (Slit-FL) [Cleaved into: Protein slit N-product (Slit-N); Protein slit C-product (Slit-C)] (P24014)
Organism: Drosophila melanogaster (Fruit fly)
Function: A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.
Subcellular location: Secreted {ECO:0000269|PubMed:2176636, ECO:0000269|PubMed:3144436, ECO:0000269|PubMed:32994163}.
Interaction partners:
- Roundabout 1, isoform A
- Roundabout 2, isoform B
- LP22668p
- Pro-resilin
- Tyrosine-protein kinase Abl
- Toll-like receptor 6
- Netrin receptor unc-5
- Syndecan
- Semaphorin 5c
- Dally-like, isoform A
Sequence:
MAAPSRTTLMPPPFRLQLRLLILPILLLLRHDAVHAEPYSGGFGSSAVSSGGLGSVGIHIPGGGVGVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLEEGRFSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHGVCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQRQQKITPGCALLEGEQQEEEDDEQDFMDETPHIKEEPVDPCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEPPTVTAASTCRKEQVREYYTENDCRSRQPLKYAKCVGGCGNQCCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCGCTKKCY
Protein: Glycine-rich RNA-binding protein 3, mitochondrial (AtGR-RBP3) (AtRBG3) (Mitochondrial RNA-binding protein 2a) (At-mRBP2a) (Organelle RRM domain-containing protein 3) (Q9FNR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possibly has a role in RNA transcription or processing during stress (By similarity). Involved in C-to-U editing of mitochondrial RNA. Functions as minor mitochondrial editing factor. Controls 6 percent of the mitochondrial editing sites.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11972043, ECO:0000269|PubMed:26578708}.
Interaction partners:
- Zinc finger protein VAR3, chloroplastic
- Multiple organellar RNA editing factor 8, chloroplastic/mitochondrial
- Multiple organellar RNA editing factor 1, mitochondrial
- Protoporphyrinogen oxidase 1, chloroplastic
- Pentatricopeptide repeat-containing protein At5g13270
- Peptidyl-prolyl cis-trans isomerase
- Uncharacterized mitochondrial protein AtMg01000
- Tubby-like F-box protein 1
- U1 small nuclear ribonucleoprotein C
Sequence:
MAFLSKFGNILKQTTNKQLNAQVSLSSPSLFQAIRCMSSSKLFIGGMAYSMDEDSLREAFTKYGEVVDTRVILDRETGRSRGFGFVTFTSSEAASSAIQALDGRDLHGRVVKVNYANDRTSGGGFGGGGYGGGGGGYGGSGGYGGGAGGYGGSGGYGGGAGGYGGNSGGGYGGNAAGGYGGSGAGGYGGDATGHGGAGGGYGSSGGFGSSGNTYGEGSSASAGAVGDYNGSSGYGSANTYGSSNGGFAGDSQFGGSPVGNSSQFGGDNTQFTAGGQFGGEDQFGSMEKSETKMEDGPIGGEFEDVAKRA
Protein: Antitoxin MazE3 (O53451)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin.
Interaction partners:
- Endoribonuclease MazF3
- Antitoxin MazE6
- Probable antitoxin MazE2
- Antitoxin MazE8
- Probable endoribonuclease MazF7
- Putative antitoxin Rv0268c
- Ribonuclease VapC46
- Putative toxin HigB2
- Toxin ParE1
- Endoribonuclease MazF6
Sequence:
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALDID