wanglab/gogpt-training-data huggingface dataset:
Protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP2 (EC 2.7.4.24) (Protein VIP HOMOLOG 1) (VIP1 homolog protein 2) (Arabidopsis homolog protein of yeast VIP1 2) (AtVIP2) (Q84WW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Probably involved in vitamin E homeostasis via the regulation of gamma-tocopherol biosynthesis (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43314}.
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Inositol-pentakisphosphate 2-kinase
- Inositol-pentakisphosphate 2-kinase
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP1
- Inositol-tetrakisphosphate 1-kinase 2
- SPX domain-containing protein 1
- Inositol-tetrakisphosphate 1-kinase 1
- Protein PHR1-LIKE 1
- Protein PHOSPHATE STARVATION RESPONSE 1
- Inositol 1,3,4-trisphosphate 5/6-kinase 4
Sequence:
MGVEEGAGVDKKITIGVCVMEKKVFSAPMGQIMDRIHAFGEFEIIHFGDKVILEDPVESWPICDCLIAFYSSGYPLEKVQAYSSLRKPFLVNELDPQYLLHDRRKVYEHLEMYGIPVPRYACVNRKVPDEDLDYFVEEEDFVEVKGERFWKPFVEKPVNGDDHSIMIYYPSSAGGGMKELFRKVGNRSSEFHPDVRRVRREGSYIYEEFMPTGGTDVKVYTVGPEYAHAEARKSPVVDGVVMRNPDGKEVRYPVLLTPAEKQMAREVCIAFRQAVCGFDLLRSEGSSYVCDVNGWSFVKNSYKYYDDAACVLRKMFLDAKAPHLSSTIPPILPWKINEPVQSNEGLTRQGSGIIGTFGQSEELRCVIAIVRHGDRTPKQKVKLKVTEEKLLNLMLKYNGGKPRAETKLKTAVQLQDLLDATRMLIPRARSGESDSDAEDLEHADKLRQVKAVLEEGGHFSGIYRKVQLKPLKWVNVPKSDGEGEEERPVEALMVLKYGGVLTHAGRKQAEELGRYFRNNMYPGEGTGLLRLHSTYRHDLKIYSSDEGRVQMSAAAFAKGLLDLEGQLTPILVSLVSKDSSMLDGLDNASSEMEAAKAQLNEIITAGSKMVHDHVSSELPWMTDGAGLPPHADEHLPELVKLAKKVTEQVRLLAQDEHENLAEPSAYDVVPPYDQAKALGKSNIDVGRIAAGLPCGSEGFLLMFARWRKLERDLYNERRERFDITQIPDVYDSCKYDLLHNSHLDLKGLDELFKVAQLLADGVIPNEYGINPQQKLKIGSKIARRLLGKILIDLRNTREEAMSVAELKNSQDQVSVSLYSSRKEDRYSQPKLFVKSDELRRPSTGENKEEDDDKETKYRLDPKYANVMTPERHVRTRLYFTSESHIHSLMNVLRYCNLDESLQGEESLVCQSALDRLCKTKELDYMSYVVLRLFENTEISLDDPKRFRIELTFSRGADLSPLEKKDEEAESLLREHTLPIMGPERLQEVGSCLTLETMEKMIRPFAMPAEDFPPPCTPAGFSGYFSKSAAVLERLVKLWPFHKNTSNGKS
Protein: Phosducin (PHD) (33 kDa phototransducing protein) (Rod photoreceptor 1) (RPR-1) (Q9QW08)
Organism: Mus musculus (Mouse)
Function: Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P20941}. Nucleus {ECO:0000250|UniProtKB:P20941}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P19632}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P19632}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Oxygen-regulated protein 1
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein subunit beta-4
- Rhodopsin
- Recoverin
- Short-wave-sensitive opsin 1
Sequence:
MEEAASQSLEEDFEGQATHTGPKGVINDWRKFKLESEDGDSIPPSKKEILRQMSSPQSRDDSKERMSRKMSIQEYELIHQDKEDESCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGEQFLETIEKEQKVTTIVVNIYEDGVRGCDALNSSLACLAVEYPMVKFCKIKASNTGAGDRFSTDVLPTLLVYKGGELISNFISVAEQFAEEFFAVDVESFLNEYGLLPEREIHDLEQTNMEDEDIE
Protein: Growth hormone 1 (Q5EC27)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
AFPAMSLSGLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDGTPRAGQILKQTYDKFDTNMRSDDALLKNYGLFSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: L-fucose isomerase (FucIase) (FucIso) (EC 5.3.1.25) (6-deoxy-L-galactose isomerase) (D-arabinose isomerase) (EC 5.3.1.3) (P69922)
Organism: Escherichia coli (strain K12)
Function: Converts the aldose L-fucose into the corresponding ketose L-fuculose. Also converts D-arabinose into D-ribulose. In addition, catalyzes the isomerization of L-xylulose to L-xylose.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- L-fuculokinase
- L-fucose mutarotase
- L-fucose-proton symporter
- L-rhamnose isomerase
- L-Rhamnulokinase
- L-fuculose phosphate aldolase
- Fructokinase
- HTH-type transcriptional regulator MalT
- Lactaldehyde reductase
- Rhamnulose-1-phosphate aldolase
Sequence:
MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALLTEKLRHACGAAVECVISDTCIAGMAEAAACEEKFSSQNVGLTITVTPCWCYGSETIDMDPTRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSLGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDENNKQYQRNAEQSRAVLRESLLMAMCIRDMMQGNSKLADIGRVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEAILNSSFDWNGVREPFVVATENDSLNGVAMLMGHQLTGTAQVFADVRTYWSPEAIERVTGHKLDGLAEHGIIHLINSGSAALDGSCKQRDSEGNPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLASMLRIPVCMHNVEETKVYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
Protein: Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) (Q8N137)
Organism: Homo sapiens (Human)
Function: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16275750}. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
Interaction partners:
- Pericentrin
- Ninein
- Centrin-2
- Centlein
- Centrosomal protein of 135 kDa
- Outer dense fiber protein 2
- Breast cancer type 2 susceptibility protein
- Centrosomal protein of 120 kDa
- Centriolar coiled-coil protein of 110 kDa
- Spindle assembly abnormal protein 6 homolog
Sequence:
MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDLTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETVPQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSHSQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR
Protein: Ubiquitin-conjugating enzyme E2-18 kDa (EC 2.3.2.23) (Ubiquitin conjugating enzyme 10) (Q7K738)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Likely to function with ari-1 to control metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and it's heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A. Able to function with LUBEL to mediate 'Lys-63'- and linear 'Met-1'-linked polyubiquitin involved in the heat stress response.
Interaction partners:
- E3 ubiquitin-protein ligase ariadne-1
- Ubiquitin-conjugating enzyme E2-18 kDa
- Ubiquitin-conjugating enzyme E2-18 kDa
- RBR-type E3 ubiquitin transferase
- Potential E3 ubiquitin-protein ligase ariadne-2
- GEO06356p1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- LD28546p
- E3 ubiquitin-protein ligase Su
Sequence:
MTAPRRLRKELSDLQGNALKSFRDIKADDDNLLRWTGLIVPDNPPYNKGAFRIEINFPAEYPFKPPKINFKTRIYHPNIDEKGQVCLPIISTENWKPATRTDQVVQALVDLINDPEPEHPLRAELAEEFLKDRKKFVKNAEDYTKKHSEKRPAD
Protein: Regulator of chromosome condensation, putative (Q57WT1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRPLVERFLRGDNSVLSQILMRVESQGDPTFGDSSERLYNRLIEMLVHEGRRASGSARGSPSNKENCFVAIRVFNIIFERAGVDAPVLRRCLTESGSNNARMMNLDHYFSQQGHMNMHVARFALTLTKIYRISVETLLTAAPNIVHVERLAGSRENSNAQSSASSHDDNVSPMRGTFSAARSNLRGEGRSVSNPRAGRGADGARVELFQAVGNSNRHWRELPDAPSFVPFSVNPLYSENVGASNHTWMPPQFPTPVLLFSRHFGAGCEAKLPIMGAITAQQTGEQLDAEDAIASPTPERVGDGGEAVEEVVAGEKPPDLLLSRYLAKGAVLTWGNIASVKTGKKLQLASPSDGESPPQGSYTLSPTRLAIPVPVVSFSCGAYSCYFVTMERKILSCGNDDWGQLGAGKSKDSQPPGAVKGSEGKYRLYRVPLRSGDQICKLAAGSAFAVAIGLRSRRMYLWGQNSFGQCLVHEGMTVRTPVLVDIPGQYTEVVDVACGGFYAALSFTCGSVGTWGLSTMLATNVSPDQLRDADAPNNQKCAKTINLFKPLNEKVVALRAGPCHCLAITSSGAVYSWGVERNGRLGHGSGKNEEKMRLIDALSNQVVTDASCGSFHTAVLTKQGQIFVFGENTYGQLGLPTRQPRLLPEILPLPKRAISVSCGREHTCILLEDGDVMACGSLRCSGVGVGFGSRFVAPRRAVQNYLILTLASGDLHVLAAGLLRTMALTVVQTPPESPILDDLPKVNEVARRHGLRGVSAGNGFTIILAETGEAFSIGQGENGQLGMGDTSLSQKTALRKVVVPDFEELCAVECGFNFAIAIGSSGALYSWGWNTHGQLGHGVAVNLGEAVFTPKEISALKSLAQVVQVACGGTFVIALTQCGEVYSWGETLYCGHGTGGERCLTNPKRIAALQDIAAVAAGDRHAAAVSYDHVIYAWGRGPVGDGGSPSTVVPVPVAVKFAHPVRQLVCCQVNTFIITDVGDLYVWGLNNNGQCGALQSMINSDHSTSTLRQKGDEDGGMKSDQQPLLFPTFVASGVREAAFTKMCGVYVKEDGSSYVCGRVRQNGRDVTLKSFTQQWVGRPPSERDGETGAASPSSYFVRCFHGYDSIFQLVERKRQTPASLKTTRQNLSAFVRGSKEKAFYQRNNQNREK
Protein: RIKEN cDNA 4930474N05 gene (Q8BVR5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFSWCLRTTRGLGLKKENREGHGSVWRHRVHSCLQRLWPFSRKGKTVTKGKQDQNHTDQDLREPRRESPISAEMVVKLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHPHSVEHRQVRSSLCNFLHTWMDKNPEDFCDPSDMLPLTYLKAYLSVHMPHSELFIRVDRLLNELWEEQDKDSHAKNEEDSDLGRHTSSDPELKRCK
Protein: Octopamine receptor beta-2R (DmOct-beta-12) (DmOct-beta-2R) (Q4LBB9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tyramine beta-hydroxylase
- MIP05841p)
Sequence:
MLLCDGLGPEPPRQRHRNRTSAARIRKRPKCCCGDGGSGNQAEQPGGIVSNPISYGQSLTTLARVTAAALTTAAMLHTTNALAATGSSSASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQMVDNL
Protein: Eig71Ej (GEO11774p1) (L71-10) (Q24077)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRYLCVFSLTLILCCLSIKAQSLNCTRLRENCRPCTRRLVDPINDLEFINSDCREKLRGRWIWRDVRRCDMQIVACENHETRLDCENVARLTGMRRIR
Protein: FH protein interacting protein FIP2 (BTB/POZ domain-containing protein At5g55000) (Q9SE95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
- Formin-like protein 2
- Exocyst complex component SEC10a
- Formin-like protein 4
- Formin-like protein 8
- Formin-like protein 14
Sequence:
METSSNLSSMVRLNIGGKKFCTTIDTLTIREPDSMLAAMFSGRHAMCQESKKGYVFIDRDGKHFRHILNWLRDGVIPSLSDPDCSELLREADYYQLLGLKDGIKDSRKEVGEVEAELTRIDIIKCIQTERVRFRGVNLSGIDLSKLDLSLVDFSYACLRNVFFSRTNLQCAKFRNADAEGSIFHNAILRECEFTSANLRGALLAGTNLQSANLQDACLVGCSFCGADLRTAHLQNADLTNANLEGANLEGANLKGAKLSNANFKGANLQRAYLRHVNLREAHMEGANLGGANMTGAIR
Protein: Alpha-conotoxin PnIA (Alpha-PnIA) (P50984)
Organism: Conus pennaceus (Feathered cone) (Conus episcopus)
Function: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=7-68 nM) and alpha-7/CHRNA7 (IC(50)=253 nM) nAChRs. It also shows a high inhibition on alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=11 nM) and a low inhibition on alpha-6-beta-4/CHRNA4-CHRNB4 (IC(50)>500 nM). It interacts with a hydrophobic pocket between two acetylcholine receptor subunits. In vivo, inhibits Ehrlich carcinoma growth and increase mouse survival. These effects are greatly enhanced when the toxin is applied with the selective 12-lipoxygenase inhibitor baicalein.
Subcellular location: Secreted {ECO:0000269|PubMed:8068627}.
Interaction partners:
Sequence:
GCCSLPPCAANNPDYC
Protein: PR domain zinc finger protein 1 (EC 2.1.1.-) (Q68EH4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR013212}. Cytoplasm {ECO:0000256|PIRNR:PIRNR013212}.
Interaction partners:
- Nanos homolog 3
- T-box transcription factor Tb.
Sequence:
MCGWDQSVLAPYQNSAMLTTEAAPYTADNEELKMDVEDVDMTKWTEDEFEEKCTYIVKDHTWEGPLENTDLTRAEASLPRNLAFKHPADSKEVIGVVSREYIPKGTRFGPLVGESYTAENVPKDANRKYFWRIYSDGEFHHFVDGLDEEKSNWMRYVNPAHSQQEQNLAACQNGMNIYFYTVKAIPADQELLVWYCPEFARRLNYPASGEIMMQKLKQSLIEAKQQATEVKHPVKREHSVSEILKDVLQEPSRPLPTRPRCPKSPDRPLYPSAVYPPRPSLNEDFLKSTTVFGLPTRSHTQCSVTPSPSAHSSPERSPGSSPTSASIEPREAFLPFSPALYNRGLNHYPGYSPAGSMPFYPNPHYSRYLMHHYPVSSLSGPSTLGGIFPHMYPFYSSLVPPHVPFPPSMLSSEGSRQFMLPPDSPAPRDILLPAATSAFSAATSLKDKPLHGHGHPYAPAGGSPTAGSAASTGCIPTKPTSAILSTSRSEDEAINLSKMKRGSTGYKSLDYPLKKQNGKIKYECNVCTKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKICPAKFTQFVHLKLHKRLHTRERPHQCPHCHHNYIHLSSLRFHLKGYCLAVSPSPSCSLDELNRVNEEIERFDISDNADRLEEMEGFDVEGMVEKQIFGLLWQEMDFKASYHKGSTGGDLHPRAPALSAYHLNEHDSEASVIKVHRSSPIQLLPIKVKKETEEAMDT
Protein: Rifin (Q8IHM2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVYYINILLFAFPLNILVYNQWNHKSTTHHTPKVPTTRLLYECELYIPNYDNDPEMKRIMQQFDDRTSQRFHEYDNRMIEKQQKCKDQCDKEIQKIILKDKLEKELMEKFATLQTDIQNDAIPTCVCEKSLADKTEKFCLNCGKTMGAVAPAWGLISCIGYVGWSQYVAAKIVEAGIKNGLEVGLLKVTEAATSMSQLTASDIPKITIEKMLSSGTFTDKMTFSDICNYINTIMSSELESKGYTKYTFALENIAKPSKIKYHYSKQSADVLAAITEGKTAESLKLSPYTSILTNTIIASIIAIVVIVLVMVIIYLILRYRRKKKMKKKLEYMKLLKE
Protein: Dof zinc finger protein DOF5.3 (AtDOF5.3) (Protein PHLOEM EARLY DOF TMO6) (Protein TARGET OF MONOPTEROS 6) (Protein TARGET OF MP 6) (Q84TE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity). The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression that promotes radial growth of protophloem sieve elements.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00071}.
Interaction partners:
- Leucine-rich repeat receptor-like protein kinase TDR
- LOB domain-containing protein 4
- Transcription factor AIG1
- Homeobox-leucine zipper protein ATHB-8
- WUSCHEL-related homeobox 14
- WUSCHEL-related homeobox 4
- Transcription factor LHW
- CLAVATA3/ESR
- CLAVATA3/ESR
- AT3g15630/MSJ11_3
Sequence:
MDHLLQHQDVFGNYNKAREAMGLSYSSNPTPLDNDQKKPSPATAVTRPQPPELALRCPRCDSTNTKFCYYNNYSLTQPRYFCKSCRRYWTKGGTLRNIPVGGGCRKNKRSTSSAARSLRTTPEPASHDGKVFSAAGFNGYSNNEHIDLSLAFALLNKQHPGSSSQLGFHSELGSSHQSDMEGMFGTSQQKENATYAFGNGSSGLGDPSRVLWGFPWQMNGESFGMMNIGGGGGHVDQIDSGREMWTNMNYINSGALM
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q54VX1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MADNENNTANNESINTAVTTTPSTTTTTPSTTTTTPSTTTTPSTTTTTPSTTTTATTTPPPTTTTTTNTATNTNINTNTNTNIRQPQYWCHQCKKYVRLSDPEEIICPDCASEFLEEAEESNRPTSPYSFLQNMNTSNNNNNNSNNNNNNTSANSNPFSRTRVSNNEFNMDPLLFLSSLFPQVSSSNTSGARTNVFGAPRQRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQRTRSSSTSSDVENNDSSEDDFDFGLQMPQAVEIDQVLFNISQLLGGVPSMGGFGVMGGGGGGGARGYVGNPNDYFQGGDWQGFLNRMFQASKKKGTPPASKEEIEKLKRDRVDQTIVDQKVDCAVCKDEFKWGDDYIELPCQHLYHPECILPWLEQHNSCPVCRFELKTDDDSYEKDKELKREMEQQQQNSEEDDDNIDDQNTTTTTTTTSTNNNESEDDSMHE
Protein: Kappa-casein (E7E1P8)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
QYVLSRYPSYGLNYYQQKPVALINNQFLPYPYYAKPAAVRSPAQILQWQVLSNTVPAKSCQAQPTTMARHPHPHLSFMAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIEGPPEINTVQVTSTAV
Protein: Probable fibrosin-1 (Q8R089)
Organism: Mus musculus (Mouse)
Interaction partners:
- Polycomb group RING finger protein 5
- Polycomb group RING finger protein 3
- E3 ubiquitin-protein ligase RING2
- RING1 and YY1-binding protein
- E3 ubiquitin-protein ligase RING1
- Methyl-CpG-binding domain protein 6
- Casein kinase II subunit alpha'
- Polycomb group RING finger protein 6
- YY1-associated factor 2
Sequence:
MFEKYPGKMEGLFRHNPYMAFPPAVPGLPPGLPPAVSFGSLQGAFQPKNTNPELPPRLGPVLSGLPQKGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRHQEKMKGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTTAPGAHGPFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFNSSAVFAQKESPGAPPAFASPPDPWGRLHRSPLAFPAWVRPPETARTPGSDKERPMERREPSVTKEEKDRDLPFSRPQLRVSPATPKARAGEEGARPAKESVRVKEERKEEAAAAAAAAAAAAAAAAAAAAAAAATTGPQGLHLLLERPRPPPFLGPSLPERCAGFPEPTWLAGPPRLARPPRFYEAGEELTGPGAMAAARLYSLDPAHPLLYSRLAPPPPPTATPGTPHLLSKTPPGALLGAPPPLVPAPRPSSPPRAPGPARADR
Protein: Lipase A, lysosomal acid type (A0A0A0MT32)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
Protein: Aquaporin (Q19949)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Putative aquaporin-10
- Aquaporin
- Aquaporin
- VWFA domain-containing protein
- Probable glycerol kinase
- Aquaporin
Sequence:
MLLRFIRKIMTAEEDTLPERLRFHGVHTNILARNLIAEFFGTFLLCFIGLSIVFQFHAGGGKTTEWIGVNIGWGFAIMFAVMATARMSGGHLNPAVSLLLWSLGHLKLAWVPLYAIAQTAGAFVASLGMYSYYYEQFNAFDGGNRTILGATGTAGCFASYPSPNLGVWGPYIDQCVGTGVLAYFLCVVIDERNQIPKIWHPMFFGFLVMMIGTGFGMNIGYPINPARDLGPRLFSYFIYGPGVFHSPYPNYWLAPAIAPFVGALVGGWFYHFSLGMHNPDIEEADDIFVQQPPKSVEQQKLLQA
Protein: DNA-directed RNA polymerase III subunit rpc5 (RNA polymerase III subunit C5) (RNA polymerase III subunit C37) (O74883)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerase III subunit rpc3
- Probable DNA-directed RNA polymerase III subunit rpc6
- DNA-directed RNA polymerase III subunit rpc31
- DNA-directed RNA polymerase III subunit rpc4
- DNA-directed RNA polymerase III subunit rpc9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit rpc8
- DNA-directed RNA polymerase III subunit rpc1
Sequence:
MSFSEDQAMEEAKLRNDETEEQDPVVRTYPVFFSPGLRNNLLLNQFPLRPKNRTYSDANGEAPIDVRVKPKTGWMEVDVPIPTTKYYNEDKAMKYGNGKKPIQTQTLSGRLQKPRTNLMVGLIRDGQFHIVPLRGLTQLRPSMKHVNEYTQKLKAAAGPSNSSSGTSTPRGPIRAVQVTAKQNTEAPKVSTTHIVRATEEEEWVELDCRPERESESILKQLECPIEHQPNECAAVDEDYSFI
Protein: Prolactin family 8, subfamily A, member 2 (A0A8I5ZMH5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
PCPISVKNFAGALLMLVISNLLLWEKTASVPACHLEEGGCWDPLVNTFNSAIQRAEVIQNLAEQIHEDSFIQFWNCIFYLQVARMYRHDQAVYRARYHCPSNSTNPPLHGPEHENIKTKKYLKMMINFVGSWISPLFHLVLELRGMQNVPEVILSKAKDIEENNREILEDLRWILTKVYPTAKMKEKIISWDYLSSIKSNEKSEKFLAIFNISHCLRVDIFYTKFHLRALMCRITGKEC
Protein: T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5) (P17542)
Organism: Homo sapiens (Human)
Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor 12
- LIM domain-binding protein 1
- Transcription factor E2-alpha
- Rhombotin-2
- Erythroid transcription factor
- Endothelial transcription factor GATA-2
- Runt-related transcription factor 1
- LIM domain-binding protein 2
- Trans-acting T-cell-specific transcription factor GATA-3
- Rhombotin-1
Sequence:
MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGPGGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQLSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAASPDSYTEEPAPKHTARSLHPAMLPAADGAGPR
Protein: Calcium-binding EF hand family protein (F4HY32)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g57460
- AP-2 complex subunit sigma
- AP-2 complex subunit alpha-1
- Beta-adaptin-like protein B
- AP-2 complex subunit mu
- Clathrin heavy chain 1
- At2g46250/T3F17.10
- Transducin/WD40 repeat-like superfamily protein
- AP-2 complex subunit alpha-2
- Clathrin heavy chain 2
Sequence:
MAAPRPTGGQDLFDTYFRRADLDGDGHISGAEAVAFFQGSNLPKHVLAQVWSYADSKKAGYLGRAEFYNALKLVTVAQSRRELTAEIVKAAIYSPASANIPAPKINLAATPSPQPRGVLPATQAQGVTSMPSVAAGVRGPHMGGTVSTSNQQVVPGQQNQFTGIPPSQTQQNFQSPGMPAGGTNAPRPANQPMPSDWLSGRSVGPSGNVNSQIPSSQSTYGLTAPNSTANHITKPHITPAVTSSTTTRPQESAPVHNPQESSATFGSRVSNVPSNQLVPKDPKELAASGNGFTSDSLFGDVFSVTSTQPKQHPTGSASTTGISSVTTGTVAGPEITQSVVRQSSIPQQGSLSQHAVGVQTQLTGNSGQPYTSSGAASGPPGSTVGVGISATSQLAQRPPHPHSQPQPRPQGQSQPPWPKMTPADVQKYTKVFVQVDTDRDGKITGNQARNLFLSWRLPRDALKQVWDLSDQDNDSMLSLREFCIAVYLMERYREGRPLPPVFPSSIIHSESMFTSPGQSVAPHGNASWGHPQGFQQQPHPGGLRPPAGPKGKPPRPVPLSPSDGMVQPTQPKRKMPVLEKPLVDQLSKEEQDSLNTKFEEATAVDKKFSFFAFSIRRYLLPLPYGIYMKYLWICVAIVDELEKEIADSKQKIDFFRAKMQELVLYKSRCDNRYNEIAERVLGDKRELESLAKKYEEKYKKSGNVGSKLTIEEATFRDIQEKKMELYQAIVKFEEGKLDDSIVKRTEHIQSGLEELIKNLNERCKQYGVRGKPTSLVELPFGWQPGIQEGAADWDEDWDKLEDEGFTFVKELTLDIQNVIAPPKEKSSAWRKEVDVSSKEGEDVSFSDADSKTGKKQSSGEEDSEQSEGKTSDVDARDKNGSLDDSKVRKGIEADSSPRTKDTRSENGHDDGESTASAGKTVNYDSHDETDSVSSVNPDNGKDKDHGKYDSGFGFGFGFDDFSIKPIKTGSTISNDFLPPKLSIFADSVPSPPANASDVSPTKPSLFADSVPSTPATNNASYPGQKSFFDDSVPSTPAYPGNLFAEKKSFFDDSVPSTPAYPGNLFAEKKSYFDDSVPSTPAYSTSDFGGKPFASETPRSDNLFPGRSPFMFDSVPSTPAAHDDFSNNSFSRFDSFNSNNNDAFSLSRTDSMRSTSEPDPFASRFDSFNYQRYDSFNAQSYDSSSNNNASETPKASLTRFDSIGSTRDSDYSHGFGFDDHDPFGSTGPFKTTTTTAETPRSSDNWNAF