wanglab/gogpt-training-data huggingface dataset:
Protein: TLC domain-containing protein (Q57V92)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MARHPLGNMYAMTAERAREYGFVSHYNHTGSEASDKLANNITLTSEEWVQLLTGPVQFITQSGGWGGAGFDATVLPQLLLCFPWVIAFLMFRVFTQRQLIRVGLWLQVVVPKGGTAATLSNSQRRKLKKFQNQVWLATYYIVSTIFGYAVQIGKPWFGLPVSKANRVALLTPHPYKPGNGLLCYYQYGLGFYIAEMLALLTEYDIKRSDFVEYFIHHIVTVALIVVSHCSYEHRFGVYVLLIHDASDIMLALSKILNYVLGAQAKRTRQRKAGKKVDVVEAKSSFLYRMIFCETTMNIVFVAFTAVFVFFRLVCLPYLALSNIVYGVKIRMFTWSYCLLIFLLQVALQGLHIYWFTIIVKVLINTALGSRVDDIRSEDDEDDGNVRERASFKHSKTS
Protein: Loricrin (P18165)
Organism: Mus musculus (Mouse)
Function: Major keratinocyte cell envelope protein.
Interaction partners:
- Filaggrin
- Trichohyalin
- Involucrin
- Keratin, type I cytoskeletal 10
- Keratin, type II cytoskeletal 1
- Keratin, type I cytoskeletal 14
- Hornerin
- Protein-glutamine gamma-glutamyltransferase K
- Repetin
- Keratin, type II cytoskeletal 5
Sequence:
MSHQKKQPTPCPPVGCGKTSGGGGGGGGGGGGGYYSGGGSGCGGGSSGGGSSCGGGGGGSYGGGSSCGGGGGSGGGVKYSGGGGGSSCGGGYSGGGGGSSCGGGYSGGGGGSSCGGGYSGGGGGSSCGGGSYSGGGSSCGGGGGSGGGVKYSGGGGGGGSSCGGGSSGGGGGGSSCGGGSGGGGSYCGGSSGGGSSGGCGGGSGGGKYSGGGGGSSCGGGYSGGGGSSGGSSCGGGYSGGGGSSCGGGGGYSGGGGSSCGGGSSGGGGGGSSQQYQCQSYGGGSSGGSSCGGRYSGGGGSSCGGGYSGGGGSSCGGGSSGGGSSCGGSGGGGYSGGGGGSCGGGSSGGGGGYYSSQQTSQTSCAPQQSYGGGSSGGGGSCGGGSSGGGGGGGCYSSGGGGSSGGCGGGYSGGGGGCGGGSSGGSGGGCGGGSSGGSGGGCGGGYSGGGGGGSSCGGGSSGGGSGGGKGVPVCHQTQQKQAPTWPCK
Protein: Stem-loop histone mRNA binding protein (F8W8D3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MACRPRSPPRHQSRCDGDASPPSPARWSLGRKRRADGRRWRPEDAEEAEHRGAERRPESFTTPEGPKPRSRCSDWASAVEEDEMRTRVNKEMASNIYFALRYKRKLLINDFGRERKSSSGSSDSKESMSTVPADFETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHPKTPNKFKKYSRRSWDQQIKLWKVALHFWDPPAEEGCDLQEIHPVDLESAESSSEPQTSSQDDFDVYSGTPTKVRHMDSQVEDEFDLEACLTEPLRDFSAMS
Protein: Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) (Q9DBZ9)
Organism: Mus musculus (Mouse)
Function: GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1.
Interaction partners:
- Liprin-alpha-2
Sequence:
MAEPLLRKTFSRLRGREKLPRKKSEAKDRGHPAQRSEPKPPEPEPRVLEGSQAGAEVPPSPETPRSPTRGAYLQSLEPSSRRWVLGGAKPPEEISLGPRTPSSGEPAGEIWYNPIPEEDPRPPAPEPLGSQLASSEPEGPNIQGAAPTSPPTKTSRTKSPGPARRLSMKMKKLPELRRRLSLRSTRTGRDRERTAPAGSVISRYRLDSSVGTPGQASVAGGSRSPRGGYLSDGDSPERPGGPPSPTAFRPYEVGPSARTPPAALWGRLSLHLYGLGGLRPSPGATPRDLCCLLQVDGVARARTGPLRSGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTIFRGCQAQQLAVRLEPQGFLYAKLTLSEQQEAPATAEPRVFGLPLQLLVEREQSPGQVPLIIRKCVGQIECRGLRVVGLYRLCGSAAVKKELRDAFEQDSAAVCLSEDVYPDINVITGILKDYLRELPTPLITQPLYQVVLEAMAQGHPSRASLGPEGTRGLLRCLPDVERATLTLLLDHLRLVSSFHTHNRMTPQNXAVCFGPVLLPARQTPSRPRLRSSGPGVTSAVDFKRHIEVLHYLLQSWPDTRRPSDTPDGAVAPYLRPKRQPPLHLPLAGPEVVTRPRGRGGPESPPSNRYAGDWSVCGGDLLPCGRDFLSGPDYDHVTGSDSEEDDDETGEPRGTTDFEDEFDAPFNPHLNLKDFDALILDLERELSKQINVCL
Protein: Beclin homolog (Q22592)
Organism: Caenorhabditis elegans
Function: Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde transport of mig-14. In a daf-18/PTEN- and skn-1/Nrf-dependent manner, promotes germline stem cell proliferation during late and adult stages, probably by ensuring cell survival and cell cycle progression. Required for embryonic development and L3/L4 molting during larval development. Required for normal dauer morphogenesis and lifespan. Plays a role in male tail ray pattern formation. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16111945}. Perikaryon {ECO:0000269|PubMed:17327275}. Cell projection, dendrite {ECO:0000269|PubMed:17327275}. Cell projection, axon {ECO:0000269|PubMed:17327275}. Endosome {ECO:0000269|PubMed:21183797}. Note=Co-localizes with rme-8, a component of the retromer complex, on endosomes. {ECO:0000269|PubMed:21183797}.
Interaction partners:
- Serine/threonine-protein kinase unc-51
- MRG domain-containing protein
- non-specific serine/threonine protein kinase
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Apoptosis regulator ced-9
- UV radiation resistance-associated gene protein-like
- Ubiquitin-like protein atg-12
- Autophagy-related protein 18
- Autophagy-related protein 13 homolog
- Protein lgg-1
Sequence:
MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALTGHSRNLMKLISDAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYINYLKENHPTTSIPDLKAKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAASEKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCFHIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIKLRRNGIDMETYALYGQGTPLSGSSGIDPGIRRFLQLLEFLLKELKDRNKNFKPPYQIHADSLVDNGVKYNAVMTLNTDVRWTRAMALMLTDLKAACAQCDALRSPI
Protein: CTTNBP2 N-terminal-like protein (Q99LJ0)
Organism: Mus musculus (Mouse)
Function: Regulates lamellipodial actin dynamics in a CTTN-dependent manner.
Subcellular location: Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8SX68}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:23015759}.
Interaction partners:
- Striatin-3
- Striatin-interacting protein 1
- Striatin-4
- Serine/threonine-protein kinase 24
- Striatin
- Programmed cell death protein 10
- Striatin-interacting proteins 2
- MOB-like protein phocein
- Serine/threonine-protein kinase 26
- Serine/threonine-protein kinase 25
Sequence:
MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDSEKQPVCTNPLSVLKAVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERTRHKQLSSMLVLECRKATSKAAEEGQKAGELSLKLDKEKSRASKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTRALKEEVESLKKLVKDLEAAQQHRSTSEQGREPVTMSRGTATEPPMRVSAFCQTESVQTERSHGSVITKLTDTGLPGPTTAAYSYAKANGHCDPEIQTTRELTSDSSTENQGPPREKSAVAAQEKPVENGGCPVGTETPVTMPSHLPSSGSSLSPSSTASSSLTSSPCSSPVLTKRLLGSAASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLLDNSAAKQLARNTVTQVLSRFTNQGPIKPVSPNSSPFGTDYRNLASTASPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSQSATTPVTKTHSQASSLAATEDLASSCSPSAVVANGKDVEILLPTSS
Protein: Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase) (Q61576)
Organism: Mus musculus (Mouse)
Function: PPIases accelerate the folding of proteins during protein synthesis.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:11071917}.
Interaction partners:
- Serpin H1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Cartilage-associated protein
- Prolyl 3-hydroxylase 1
- Elastin
- Trimeric intracellular cation channel type B
- Collagen alpha-2
- EGF-containing fibulin-like extracellular matrix protein 2
- Collagen alpha-1
- Pigment epithelium-derived factor
Sequence:
MFLVGSSSHTLHRLRILPLLLLLQTLERGLGRASPAGAPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPDATLYFDVVLLDVWNKADTVQSTILLRPPYCPRMVQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLVFYVLLLDVHNPKDTVQLETLELPQGCVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFHNPSDPVEIKTLSRPPENCNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARGVPGSAVLLFEVELVSREDGLPTGYLFVWYQDPSTSLFEDMDLNKDGEVPPEEFSSFIKAQVNEGKGRLMPGQDPDKTISDMFQNQDRNQDGKITAEELKLKSDEDQERVHEEL
Protein: Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2) (P13349)
Organism: Homo sapiens (Human)
Function: Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Subcellular location: Nucleus {ECO:0000269|PubMed:29887215}.
Interaction partners:
- Paired box protein Pax-3
- Transcription factor E2-alpha
- Myogenic factor 6
- Paired box protein Pax-7
- Myocyte-specific enhancer factor 2A
- Growth/differentiation factor 8
- Myocyte-specific enhancer factor 2C
- Myogenin
- Cadherin-15
- Homeobox protein SIX1
Sequence:
MDVMDGCQFSPSEYFYDGSCIPSPEGEFGDEFVPRVAAFGAHKAELQGSDEDEHVRAPTGHHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTTNPNQRLPKVEILRNAIRYIESLQELLREQVENYYSLPGQSCSEPTSPTSNCSDGMPECNSPVWSRKSSTFDSIYCPDVSNVYATDKNSLSSLDCLSNIVDRITSSEQPGLPLQDLASLSPVASTDSQPATPGASSSRLIYHVL
Protein: Cytoplasmic dynein 2 light intermediate chain 1 (Q6AY43)
Organism: Rattus norvegicus (Rat)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:12432068}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical cytoplasm. {ECO:0000250|UniProtKB:Q8K0T2}.
Interaction partners:
- Cytoplasmic dynein 2 heavy chain 1
- Cytoplasmic dynein 2 intermediate chain 1
- Cytoplasmic dynein 2 intermediate chain 2
- Dynein light chain 2, cytoplasmic
- Dynein light chain roadblock-type 1
- Cytoplasmic dynein 1 heavy chain 1
- Cytoplasmic dynein 1 intermediate chain 2
- Cytoplasmic dynein 1 intermediate chain 1
- Dynein light chain Tctex-type 2B
- Cytoplasmic dynein 1 light intermediate chain 1
Sequence:
MPSETLWEIAKAEVEKRRCHGSDGDGMEIGEKSVFFIGSKNGGKTTIILRCLDRDEPAKPTLALEYTYGRKTKGHNTPKDIAHFWELGGGTSLLDLISIPITVDTLRTFSIVLVLDLSKPNDLWPTMENLLQATKSHVDKVTMKLGKANSKASSEMRQRMWSVMQKDHPDRELIDPFPIPLVIIGSKYDIFQDFDPEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKMRGVINQLAFGIDKSKSMCVDQNKPLFITAGLDSLCQIGSPPVPDSDIGKLQAHSPMELWKKVYEKLFPPKSTSTLKAIQDPARDPQYAESEVDEMRVQKDQELEQYKRSSSKTWKQIELDS
Protein: Origin recognition complex subunit 4 (Q9Y1B3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007858}.
Interaction partners:
Sequence:
MPEADRELVSIRRFLKERLQRDYTTLRGYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVLADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQLENAADGKVFGSFAENLAFLLQCLKAGGKHSKSVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRVKSRFSHRQVFLFPSLRRFEDYVDLCGDLLSLPTGNSLLLAEKIYNLQNIQSGALYFSRNHFDPGEYGFSPRLRDAWNKQICKVLATQQARSTLQALHDFDISEAYLKNFLFRLVAHLRPQSPHITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDSFNFEIIYARFSKFAKVSTTMQAVERSIVLKAFEHLRIAELIMPLTGGAGGGVGKVQKEFEMHKLALTYSQIHHCMQRYQALPTEVAQWAQSSLI
Protein: Guanylate-binding protein 4 (EC 3.6.5.-) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4) (A4UUI3)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96PP9}. Cytoplasm {ECO:0000250|UniProtKB:Q96PP9}. Nucleus {ECO:0000250|UniProtKB:Q96PP9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PP9}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000250|UniProtKB:Q96PP9}.
Interaction partners:
- Guanylate-binding protein 2
- Interferon regulatory factor 7
Sequence:
MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL
Protein: Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A) (O14972)
Organism: Homo sapiens (Human)
Function: Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.
Subcellular location: Endosome {ECO:0000305|PubMed:28892079}.
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- VPS35 endosomal protein-sorting factor-like
- Coiled-coil domain-containing protein 93
- Coiled-coil domain-containing protein 22
- COMM domain-containing protein 1
- COMM domain-containing protein 4
- DENN domain-containing protein 10
- COMM domain-containing protein 6
- COMM domain-containing protein 2
- COMM domain-containing protein 3
Sequence:
MGTALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHPDHLITENFPLKLCRI
Protein: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (P47095)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Methylthioribose-1-phosphate isomerase
- Enolase-phosphatase E1
- Acireductone dioxygenase-requiring))
- Polyol phosphate phosphatase PYP1
- S-methyl-5'-thioadenosine phosphorylase
- Xylulose kinase
- Triosephosphate isomerase
- Fructose-1,6-bisphosphatase
- Purine nucleoside phosphorylase
- Alcohol dehydrogenase 4
Sequence:
MSSQDVLIHSDDPCHPANLICTLCKQFFHNNWCTGTGGGISIKDPNTNYYYLAPSGVQKEKMIPEDLFVMDAQTLEYLRSPKLYKPSACTPLFLACYQKKNAGAIIHTHSQNAVICSLLFGDEFRIANIEQIKAIPSGKVDPVTKKPMALSFFDTLKIPIIENMAHEDELIDDLHKTFKDYPDTCAVIVRRHGIFVWGPTIDKAKIFNEAIDYLMELAIKMYQMGIPPDCGIGEEKKHLKMASP
Protein: Putative glycerol-3-phosphate transporter 2 (G-3-P transporter 2) (Glycerol-3-phosphate permease 2) (AtG3Pp2) (G-3-P permease 2) (Protein ROOT HAIR SPECIFIC 15) (AtRHS15) (Q9SB41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein SEED AND ROOT HAIR PROTECTIVE PROTEIN
- Putative pectinesterase/pectinesterase inhibitor 24
- Peroxidase 73
- Probable pectate lyase 16
- Extensin-like protein
- Fasciclin-like arabinogalactan protein 6
- Protein DETOXIFICATION 31
- Proline-rich extensin-like family protein
- Proline-rich extensin-like family protein
Sequence:
MASWTSSQFLYEETKPWGIQFLEKFKRSGRLSFKQYQALVFILTFVAYIAFHAARKPNSIVKGTLSASTIEGGWAPFDGPDGTALLGQIDLAFLSVYAVGMFVAGHLGDRLDLRTFLTIGMIGTGLFTALFGVAFWANFHSFYYFLAVQVMAGLFQSIGWPCIVAVLGNWFDKKRRGMIMGVWSAHTSLGNIAGSLIASGLLRYGWGWSFLGPAFLMTFLGIVVYLFLPVNPPTVEAERDGTEIDSTMRLGDTITESLLESRMSTGFDRKAVGFMAAWKIPGVAPFAFCLFFTKLVSYTFLYWLPFYVSHNMIGGEYLSEETSGNLSTIFDVGGVVGGVLAGYISDQLNGRAITAAGFMYLAIPALFLYRVFGHISLTINVILMFTSGVFIIGPFALITTAVSADLGTHKSLKGNARALATVSAIIDGTGSVGAAIGPVLTGYISAISWDAVFYMLMTAALISGLLLTKLIIAEVKALLFGSEDEVAASSSSPPASRPPIDVLV
Protein: Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5) (Q05196)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Eukaryotic translation initiation factor 4G
- Initiation factor eIF-4 gamma, MA3
- Nuclear cap-binding protein subunit 1
- ATA20 protein
- Polyadenylate-binding protein-interacting protein 3
- Polyadenylate-binding protein-interacting protein 7
- Nuclear cap-binding protein subunit 2
- E3 ubiquitin-protein ligase RMA
- Eukaryotic translation initiation factor 4E-1
- Non-specific lipid-transfer protein 12
Sequence:
MAAAVASGIAPTTAMVDQVIPNQPTVAAAAPPPFPAVSQVAAVAAAAAAAEALQTHPNSSLYVGDLDPSVNESHLLDLFNQVAPVHNLRVCRDLTHRSLGYAYVNFANPEDASRAMESLNYAPIRDRPIRIMLSNRDPSTRLSGKGNVFIKNLDASIDNKALYETFSSFGTILSCKVAMDVVGRSKGYGFVQFEKEETAQAAIDKLNGMLLNDKQVFVGHFVRRQDRARSESGAVPSFTNVYVKNLPKEITDDELKKTFGKYGDISSAVVMKDQSGNSRSFGFVNFVSPEAAAVAVEKMNGISLGEDVLYVGRAQKKSDREEELRRKFEQERISRFEKLQGSNLYLKNLDDSVNDEKLKEMFSEYGNVTSCKVMMNSQGLSRGFGFVAYSNPEEALLAMKEMNGKMIGRKPLYVALAQRKEERQAHLQSLFTQIRSPGTMSPVPSPMSGFHHHPPGGPMSGPHHPMFIGHNGQGLVPSQPMGYGYQVQFMPGMRPGAGPPNFMMPFPLQRQTQPGPRVGFRRGANNMQQQFQQQQMLQQNASRFMGGAGNRRNGMEASAPQGIIPLPLNASANSHNAPQRSHKPTPLTISKLASDLALASPDKHPRMLGDHLYPLVEQQEPANAAKVTGMLLEMDQAEILHLLESPEALKAKVSEALDVLRRSADPAAVSSVDDQFALSSSE
Protein: Cytosine-containing mismatch-binding protein 1 (Q10241)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to cytosines in base mismatches and opposite chemically altered guanines.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- HMG box-containing protein C10F6.08c
- Non-histone chromosomal protein 6
Sequence:
MVFAIRIRQFHTTLVSAEKNGLQKLIPPRLKTIWNQMLVETKGAGNGPERFEMIRQKYKALTADEIQKYKNKLQEQFDAEKKRFMETLRSFTPTEIDSENRRRSKEAHSTGSRYYRLRHPDVPKKPSSAFILFYKELRNNPKLRQELGIPEAISTLVEETQNASKAWKELAEDKKKPFIDKSKALKEQYDKFMKEAGFR
Protein: Epididymis secretory sperm binding protein (HtrA serine peptidase 2, isoform CRA_e) (A0A384MDW9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
Protein: Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2) (Q80ZD7)
Organism: Rattus norvegicus (Rat)
Function: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q80ZD8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q80ZD8}. Perikaryon {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, axon {ECO:0000269|PubMed:12629050}. Note=Associated with axons of neuronal cells (PubMed:12629050). Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons (By similarity). {ECO:0000250|UniProtKB:Q80ZD8}.
Interaction partners:
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
Sequence:
MQPQRDLRGLWLLLLSLFLLLFEVARAGRPVVSCPANCLCASNILSCSKQQLPNVPQSLPGYTALLDLSHNNLSRLKAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMISRFPLELIKDANRLPKLTLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCVHSKKLHNVFSLDFFNCSEYKESAWEAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYAMGETFNETLSVELKVYNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV
Protein: Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Q63272)
Organism: Rattus norvegicus (Rat)
Function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion (By similarity).
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Signal transducer and activator of transcription 3
- Interleukin 2 receptor, gamma, isoform CRA_a.
- Interleukin-2
- Signal transducer and activator of transcription 5A
- Tyrosine-protein kinase
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription 1
- Interleukin-4
- Interleukin-4 receptor subunit alpha
- Signal transducer and activator of transcription
Sequence:
MAPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDLSCWFPPSHIFSIEDVDTQVLVYRLRFYFPGWFGLETCHRFGLHKDLTSAILDVHVLEHLFAQHRSDLVSGRLPVGLSLKDQGEFLSLAVLDLAQMARKQAQRPGELLKSVSYKACLPPSLRDLIQGQSFVTRRRIRRTVVQALRRVVACQADRYALMAKYILDLERLHPAATTESFLVGLPGAQEEPGCLRVTGDNGIAWSSKDQELFQTFCDFPEIVDVSIKQAPRVGPAGEHRLVTITRMDGHILEAEFPGLPEALSFVALVDGYFRLICDSRHFFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGSYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDPSGAFSLVGLSQLHRSLQELLTACWHSGLQVDGTALNLTSCCVPRPKEKSNLIVVRRGRNPTPAPGHSPSCCALTKLSFHTIPADSLEWHENLGHGSFTKIFHGHRREVVDGETHDTEVLLKVMDSRHQNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDTYLRKRGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGVDGNPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAGTLNLEADKWGFGATTWEVFSGAPMHITSLEPAKKLKFYEDRGQLPALKWTELEGLIAQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTPGIPNPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPEQQRDFQREIQILKALHCDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLHNDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYSDKSCSPSTEFLRMMGPEREGSPLCHLLELLAEGRRLPPPSTCPTEVQELMQLCWSPNPQDRPAFDTLSPQLDALWRGSPG