wanglab/gogpt-training-data huggingface dataset:
Protein: Coatomer subunit alpha-2 (Alpha-coat protein 2) (Alpha-COP 2) (Q9SJT9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit delta
- Coatomer subunit beta-1
- Coatomer subunit gamma
- Coatomer subunit epsilon-1
- Coatomer subunit beta-2
- Coatomer subunit beta'-1
- Coatomer subunit beta'-3
- Coatomer subunit beta'-2
- Coatomer subunit epsilon-2
- Structural molecule
Sequence:
MLTKFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPLFVSGGDDYKIKVWNYKTHRCLFTLLGHLDYIRTVQFHHENPWIVSASDDQTIRIWNWQSRTCISVLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIGALKKKSASPADDLMRFSQMNSDLFGGVDAIVKYVLEGHDRGVNWASFHPTLPLIVSGADDRQVKLWRMNETKAWEVDTLRGHMNNVSSVMFHAKQDIIVSNSEDKSIRVWDATKRTGIQTFRREHDRFWILAVHPEINLLAAGHDNGMIVFKLERERPAFALSGDSLFYAKDRFLRYYEYSTQKDSQVIPIRRPGTPSLNQSPRTLSYSPTENAVLICSDLDGGSYELYIIPKDSVGRSDVVQDAKRGTGGSAVFIARNRFAVLEKSTSQVLVKNLKNEVVKKSSLPIPTDAIFYAGTGNLLCRSEDKVVIFDLQQRLVLGELQTPFVRYVVWSNDMESVALLSKHTIIIASKKLVLQCTLHETIRVKSGAWDDNGVFIYTTLNHIKYCLPNGDSGIIRTLDVPIYITKVSGNTIFCLDRDGKNRAITINATEYIFKLALLRKKYDHVMSMIKNSQLCGQAMIAYLQQKGFPEVALHFVEDERIRFNLALESGNISVAVASATEINEKDHWYRLGVEALRQGNSRIVEFAYQQTKNFERLSFLYLITGNLDKLSKLMKIAEVKNNVMGQFHNALYLGDVKERVKILENAGHLPLAYITASVHGLTDIAERLAIELGDNVPSLPEGKTPSLLMPPSPIMCGGDWPLLRVMKGIFEGGLESANRGAVDEEEEDVEGDWGEGLDKFDVDGMENTDIEAILDGAEAGEEEDDEEGGWGLDLDLPPELDTPKASANARSSTFVTPPQGMPVSQIWSQKSSLAAEQAAAGSFDTAMRLLHRQLGIKNFAPLKSMFLDLFSGSHSYLRAFSSSPVVPLAIERGWSESSSPNVRGPPALVFDFSQLEAKLKSGYKATTAGKLSEALRVFLSILQTIPLVVVESRREVDEVKELVIIVKEYVLGLQLELKRREMKDDPVRQQELAAYFTHCKLQTPHLRLAYFSAMTVCYKSKNMATAAHFARSLLDTNPTIESQARTARQVMQAAERNMTDATTLNYDFRNPFVICGSTYVPIYKGQKDVACPYCTARFVPSQEGNICSVCDLAVIGADASGLLCSASQVR
Protein: Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) (P25093)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Maleylacetoacetate isomerase
- Oxaloacetate tautomerase FAHD1, mitochondrial
- Homogentisate 1,2-dioxygenase
- 4-hydroxyphenylpyruvate dioxygenase
- Fumarate hydratase, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- V
Sequence:
MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPVLSKHQHVFDETTLNSFMGLGQAAWKEARASLQNLLSASQAQLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSLQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMRPDNSKPPVYGASKRLDMELEMAFFVGPGNRFGEPIPISKAQEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVALKGEGMSQAATICRSNFKHMYWTILQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALSPA
Protein: RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa homolog) (BLAP75) (Q5XUX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells. Together with TOP3A, is essential for the resolution of meiotic recombination intermediates, a step that prevents entanglement of the parental chromosomes.
Interaction partners:
- ATP-dependent DNA helicase Q-like 4A
- DNA topoisomerase 3-alpha
- ATP-dependent DNA helicase Q-like 4B
- Crossover junction endonuclease MUS81
- DNA mismatch repair protein MSH5
- DEAD-box ATP-dependent RNA helicase FANCM
- AP-1 complex subunit sigma-1
- AP-1 complex subunit sigma-2
- AP-4 complex subunit sigma
- AP-1 complex subunit gamma-2
Sequence:
MRRRRLQLRYSSDEEEEDETGTSGVGDSVQSFGIASSIQPETSVSSNSNPNPGERIAISEVEIIDVFGNPQPTPPDSSIPTPYPVYPSESVSGNDYESPISEVLSRMGIKLKREWWVSCLSGLETSIPQFSYLDVAAKAKHCFEQFMFFDMNLCGGGVLPPNVASMNRIELAGPFVLQVDEIVNIGCPLKGRYENANAGLKRCLKLSMTDGVQRVFGMEYRPIKDLQVLAPAGLKIVVSSVQVRHGLLMLVPEIVEVLGGMVEELEEARKRLVVEVNKPPRGKRTRVGVVPSLTTRATLAAWSLNGNDTGNHVHDTGNHVNSSASGNASHTQANQGIPVHVTRTHNSSRAMDEPLASTNVGATVSRVEHMQIDTASAHGERTFSDIHSTSSNIHRAASTAGTGTSCSGACSGARSFANNVGGNSLDQTSNVTSFVEEMHIDTGRVRDTTTHIYGSDSGGVAAEFSNMVVDLEGPSVLSTNTEKPFTYLAELSQKWAVMKDTIHFVQGRIKCFLTGVKKFQFKQQSTYELLCYVDDGSLICEILLHNDVVQKRIGHSSMEVTAALSSSAPTSLNAMMKEKLKRFQLFLADFEGIMVVEMNRSSQYPVAIEMNQGCSLTDARLLLDRIKSSSRTSSSLNPVVVLSP
Protein: Nicking endonuclease (EC 3.1.21.-) (Q6QGD4)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Endonuclease responsible for the single-chain interruptions (nicks) located at specific positions in the minus strand of the viral genome.
Interaction partners:
Sequence:
MATNTKYKRDAISIMRDGIKSRYSKDGCCAICGSSEDLELHHYHTISQLIKKFAKELQLDFTDENIVLSNREAFYKKYEHELVRDVVTLCQHHHQLLHKVYTKEPPLFSANKQKAWVQKQKDKIQNPQEKTQVKTETKSGFARFL
Protein: RNA helicase (EC 3.6.4.13) (DEAD box protein 6) (E7FD91)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- Enhancer of mRNA-decapping protein 3
- m7GpppN-mRNA hydrolase
- Decapping mRNA 1A.
- Protein PAT1 homolog 1
- Enhancer of mRNA-decapping protein 4
- Decapping mRNA 1B.
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm7
- 5'-3' exoribonuclease 1
Sequence:
MSTARMENPVILGLSNQNGQMRGSVKPAGGPGGGGGGSQTTQPAQVKASSTVNNGNSQPVPTANTIIKPGDDWKKNLKLPPKDLRMKTSDVTATKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERIDLKKDSIQAVVIVPTRELALQVSQICIQVSKHMGGVKVMATTGGTNLRDDIMRLDETVHVVIATPGRILDLIKKGVAKVGQVQMIVLDEADKLLSQDFVQMMEEILSSLSKQRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLGETYLHRIGRSGRFGHLGLAINLITYDDRFNLKGIEEQLGTEIKPIPSSIDKSLYVAEYHSESGEEVKL
Protein: GH11113p (Galactokinase, isoform A (EC 2.7.1.6)) (Galactokinase, isoform B) (Galactokinase, isoform C) (Galactokinase, isoform D) (Q95U34)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- UDP-glucose 4-epimerase
- Probable galactose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- UDP-glucose 6-dehydrogenase
- Aldose 1-epimerase
- Aldose 1-epimerase
- Probable transaldolase
Sequence:
MTANGNGTAQDLGAGIEIVAPQKLQPESKVYGRVQQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPSDSQLQLRNLEEAKFTGYDADLKTLRIELPKSGGPAWYNYFLCGIKGIQESLGSQWKPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLDRRELASISAMCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPKLKGTPVTLPAGKCFVVANSLAQKNKAASSDYNERVVECRLATRWLAKRKGLINWEDIVRFIDLEEACQMDNETFEKLIKDNLTKSNYTRADICKELGVTEQELETKFLSANTRHMEQFKLRQRALHVIQESGRVAKFRKICEELAGGANKEGAKQLGELMRQSHESLRELYECSHPDVERLIAISNQQNVSARVTGAGWGGCIVAMCDSIEAADEYIKVLKRDYYAQLPTHLLERHQPNNFSEVVFATLPGNGAELYIQ
Protein: Forkhead box protein D3 (HNF3/FH transcription factor genesis) (Hepatocyte nuclear factor 3 forkhead homolog 2) (HFH-2) (Q63245)
Organism: Rattus norvegicus (Rat)
Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
LVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKR
Protein: Major facilitator superfamily domain-containing protein 12 (Q6NUT3)
Organism: Homo sapiens (Human)
Function: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells.
Subcellular location: Melanosome membrane {ECO:0000269|PubMed:33208952}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:29025994, ECO:0000269|PubMed:33208952, ECO:0000269|PubMed:37751742}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGPGPPAAGAAPSPRPLSLVARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGYEADRAASCCARYGPRKAWHLVGTVCVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVIFQFGWASTQISHLSLIPELVTNDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSSRVEPTQDISISDQLGGQDVPVFRNLSLLVVGVGAVFSLLFHLGTRERRRPHAEEPGEHTPLLAPATAQPLLLWKHWLREPAFYQVGILYMTTRLIVNLSQTYMAMYLTYSLHLPKKFIATIPLVMYLSGFLSSFLMKPINKCIGRNMTYFSGLLVILAFAAWVALAEGLGVAVYAAAVLLGAGCATILVTSLAMTADLIGPHTNSGAFVYGSMSFLDKVANGLAVMAIQSLHPCPSELCCRACVSFYHWAMVAVTGGVGVAAALCLCSLLLWPTRLRRWDRDARP
Protein: Dahlein-5.2 (P84268)
Organism: Ranoidea dahlii (Dahl's aquatic frog) (Litoria dahlii)
Function: Has no antimicrobial activity. Strongly inhibits the formation of NO by neuronal nitric oxide synthase at micromolar concentrations.
Subcellular location: Secreted {ECO:0000269|PubMed:11555873}.
Interaction partners:
Sequence:
GLLGSIGNAIGAFIANKLKPK
Protein: Protein Wnt-2 (P34889)
Organism: Caenorhabditis elegans
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1. In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore. Together with Wnt ligand cwn-1, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons. May act through the wnt receptor cfz-2 to regulate QR neuroblast descendant migration, and to direct ALM migration. Also plays a role in axon growth and guidance in HSN and male CP neurons. In addition, together with wnt ligand cwn-1, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1. Through the cam-1 receptor also probably regulates the outgrowth of neurites from RME GABAergic motor neurons. May act redundantly with other Wnt ligands such as cwn-1 and mom-2 to control seam cell polarity.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q2LMP1}.
Interaction partners:
- Frizzled-4
- Frizzled-2
- Protein mom-5
- Protein wntless homolog
- DiSHevelled related
- Tyrosine-protein kinase receptor cam-1
- Inactive tyrosine-protein kinase RYK
- Frizzled-4
- Secreted frizzled-related protein 1
- Beta-catenin/armadillo-related protein 1
Sequence:
MIPRRSCWLILLLNLLNVQSLLDASWWSTVAQLSTALAGHNVKPVCELPGLSPGQAQVCELFKDHMPAVSIGAQNAIQECQRQFTGHRWNCSTHYSTGMLGPIHKMATREAAFTYAILSAGVTHEIGRRCKQGLLTSCGCSDETKPKNVPTDWSWGGCGDNVEYGYKFSRDFIDIREKEHDPKRNHDNGRSLMNRRNNEAGRKILKRHRKPKCKCHGVSGACNMKTCWMQLPSMEQVGKILRNKYDKAIRVQINDRGNLQLLADEATKERKTRALPTDLVFMDDSPDYCRFDRHSGTLGTEGRVCKRGSGGAEGCDSLCCGRGYNTYTQEVKSKCNCKFEWCCKVVCQTCNNVTQVDICK
Protein: (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) (O22544)
Organism: Oryza sativa (Rice)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MGEITNVMEYQAIANQNLPKMIYDYYSSGAEDDWTLKENREAFSAILFRPRILIDVSKIDMSATVLGFKISMPIMIAPSAMQKMAHPDGEYATARAASAAGTIMTLSSWATSSVEEVASTGPGNPFLHLYLCKDRNVVEHLVKKTKRAGFKAIALTVDAPRLGRRETDIKNRFVLPPYLTLKKFEGLDLPEMDKSNDSGLASYVAGQIDRALTWKDVKWLQSITSLPILVKGVITAEDAKLAVHSGAAGIIVSNHGARQLDYVPATISALEEVVTAAAGRIPVYLDGGVRRGTDVFKALALGAAGVFIGKPVVFALAAEGKAGVRNLLRMMREEFELTMAFSGCTSLADITRAHIYTDAERLARPFPRL
Protein: Nuclear hormone receptor family member nhr-1 (Q21878)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor which acts in concert with the insulin/IGF-1-like signaling (IIS) pathway during osmotic stress, perhaps in response to a ligand modified by the sulfotransferase ssu-1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Sulfotransferase ssu-1
- Cysteine/serine-rich nuclear protein N-terminal domain-containing protein
Sequence:
MNGTLADQLQSHLANYGQPMVNSQRNEDPSMYMNGSAASVSHTNGSSSMGNDQKFPSYKRMAQRRKVPEGELCAVCSDLATGYHYGVASCNGCKTFFRRTIVSEQTFICQYNGNCDVNKNIRCACRHCRFNKCLLVGMDAKALQIPAIQNDRDRIGPTKKIKMSSGSDDEQATTPHRLQDQEIIDQLTQVEGLCQELRRCIIPEVTGVTHALTSPCLLFETTDLKVDVSLTNTIFKELFPASMNDIRMWNIREMRICIEWAKTFDVYQRLNLFDQFALVRNFAFAFNLLNRVFYSPDHGPDKIVFQNGAFIMRQPQQQVQLSGCRPIYTRQMDEIMIPFRKLQLSVAEFATFKAALFFNPDALDLSPQAKQEVFEERNKYLGGLFTCITQKIGIPTGVQKYGSLLMMTASIQNILAQNEENMQVMELFKNWEVDPFVKELCMKRA
Protein: Probable kynurenine--oxoglutarate transaminase BNA3 (EC 2.6.1.7) (Biosynthesis of nicotinic acid protein 3) (Kynurenine aminotransferase) (P47039)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961}.
Interaction partners:
- Kynurenine 3-monooxygenase
- Kynureninase
- Kynurenine formamidase
- Protein ARG5,6
- D-3-phosphoglycerate dehydrogenase 2
- Indoleamine 2,3-dioxygenase
- Cell division control protein 3
- Aromatic/aminoadipate aminotransferase 1
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Ornithine decarboxylase
Sequence:
MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL
Protein: Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) (Q9H7Z6)
Organism: Homo sapiens (Human)
Function: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.
Subcellular location: Nucleus {ECO:0000269|PubMed:10786633, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:31794431}. Chromosome {ECO:0000269|PubMed:33657400, ECO:0000305|PubMed:10786633}. Mitochondrion {ECO:0000269|PubMed:27768893}. Note=Translocated into the nucleus via its association with importin-alpha-1 (KPNA2) (PubMed:28991411). As part of the NSL complex, associates with the proximal part of promoters and transcription start sites (PubMed:33657400). As part of the MSL complex, associates with gene bodies (By similarity). Also localizes to mitochondria; associates with mitochondrial DNA and regulates mitochondrial gene expression (PubMed:27768893). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:33657400}.
Interaction partners:
- MSL complex subunit 3
- KAT8 regulatory NSL complex subunit 1
- E3 ubiquitin-protein ligase MSL2
- Male-specific lethal 1 homolog
- WD repeat-containing protein 5
- PHD finger protein 20
- Microspherule protein 1
- KAT8 regulatory NSL complex subunit 3
- Host cell factor 1
- Chromatin modification-related protein MEAF6
Sequence:
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
Protein: Probable acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) (O94523)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides.
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Ankyrin and IPT/TIG repeat-containing protein C26H5.05
- Putative fatty acid elongase 2
- Putative fatty acid elongase 1
- Very-long-chain 3-oxoacyl-CoA reductase
- Putative enoyl reductase C646.07c
- Lanosterol 14-alpha demethylase erg11
- Probable very-long-chain
- C-4 methylsterol oxidase erg25
- Ceramide very long chain fatty acid hydroxylase scs7
- Sphingolipid delta
Sequence:
MTAPSATAFSSATTQPTTEGNASMRKRTIPVVPSVPERKWDPKAPKHIQEQPWTMQNWWRHLNWLHCMLIFGLPMIAIYGVFTTPLQTKTLIFAIIYYAYSGLGITAGYHRLWSHRAYKAKKPLEYFLAAGGAAAFEGSIRWWSRDHRAHHRYTDTDKDPYNVKKGFWYAHVGWMIILQNPRRIGRSDVSDLNSDPFVMFNHRHFLPIASFMAFIFPSLFCGLLWGDYRGGYFYAGVCRLVFVHHATFCVNSLAHLIGSQPFDDTNSARNHFITALVTLGEGNHNYHHAFPNDYRNGLRWYEYDPTKIFIYIASLFGLAYNLNTFPDNEIQKGIVQQKQKVLDRWRAKLNWGIPLEQLPVMEFEDFLEQSKTRPLVLINGVVHDMTGFEHPGGQGLLRSAFGKDATAAFNGGVYDHTNGAHNLLSTYRVAVVRGGMEVEVWKSGAGAQLPMKDTQGQKIVRVGEQITRIQPPIEAAAAN
Protein: N-ethylmaleimide-sensitive factor attachment protein, beta b (F1Q9P4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU367013}; Peripheral membrane protein {ECO:0000256|RuleBase:RU367013}.
Interaction partners:
- Syntaxin-18
- Vesicle transport through interaction with t-SNAREs 1A
- Syntaxin 16
- Sec1 family domain-containing 1
- Vesicle-associated membrane protein 8
- Synaptobrevin homolog YKT6
- Vesicle transport through interaction with t-SNAREs 1B
- Synaptosomal-associated protein 25-B
- Synaptosomal-associated protein 25-A
- Vesicle-fusing ATPase
Sequence:
MDNSGKEKEAIQLMAEADKKVKSSGSFLGGMFGGNHKVEEACEMYARAANMFKMAKNWSAAGNAFCQAARIHMQLQNKHDSATSYVDAGNAFKKADPQEAIKCLNAAIDIYTDMGRFTIAAKHHITIAEVYESELVDIEKAIAHYEQAADYYKGEESNSSANKCLLKVASYSAQLEQYQKAIEIYEQVGSNTMDNPLLKYSAKEYFFKASLCHFIVDELNAKLAIGKYEEMFPAFSDSRECKLLKKLLEAHEEQNAEAFTEAVKEFDSISRLDQWLTTMLLRIKKTIQGDEGDLK
Protein: Arrestin-related trafficking adapter 6 (Arrestin-like protein 1) (P36117)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Protein LDB19
- Protein ROD1
- Ubiquitin ligase-binding protein BUL1
- Ubiquitin ligase-binding protein BUL2
- Protein ECM21
- Arrestin-related trafficking adapter 5
- pH-response regulator protein palF/RIM8
- Arrestin-related trafficking adapter 3
- Arrestin-related trafficking adapter 10
Sequence:
MLQFNTENDTVAPVFPMEQDINAAPDAVPLVQTTTLQVFVKLAEPIVFLKGFETNGLSEIAPSILRGSLIVRVLKPNKLKSISITFKGISRTEWPEGIPPKREEFSDVETVVNHTWPFYQADDGMNSFTLEHHSSNNSSNRPSMSDEDYLLEKSGASVYIPPTAEPPKDNSNLSLDAYERNSLSSDNLSNKPVSSDVSHDDSKLLAIQKTPLPSSSRRGSVPANFHGNSLSPHTFISDLFTKTFSNSGATPSPEQEDNYLTPSKDSKEVFIFRPGDYIYTFEQPISQSYPESIKANFGSVEYKLSIDIERFGAFKSTIHTQLPIKVVRLPSDGSVEETEAIAISKDWKDLLHYDVVIFSKEIVLNAFLPIDFHFAPLDKVTLHRIRIYLTESMEYTCNSNGNHEKARRLEPTKKFLLAEHNGPKLPHIPAGSNPLKAKNRGNILLDEKSGDLVNKDFQFEVFVPSKFTNSIRLHPDTNYDKIKAHHWIKICLRLSKKYGDNRKHFEISIDSPIHILNQLCSHANTLLPSYESHFQYCDEDGNFAPAADQQNYASHHDSNIFFPKEVLSSPVLSPNVQKMNIRIPSDLPVVRNRAESVKKSKSDNTSKKNDQSSNVFASKQLVANIYKPNQIPRELTSPQALPLSPITSPILNYQPLSNSPPPDFDFDLAKRGAADSHAIPVDPPSYFDVLKADGIELPYYDTSSSKIPELKLNKSRETLASIEEDSFNGWSQIDDLSDEDDNDGDIASGFNFKLSTSAPSENVNSHTPILQSLNMSLDGRKKNRASLHATSVLPSTIRQNNQHFNDINQMLGSSDEDAFPKSQSLNFNKKLPILKINDNVIQSNSNSNNRVDNPEDTVDSSVDITAFYDPRMSSDSKFDWEVSKNHVDPAAYSVNVASENRVLDDFKKAFREKRK
Protein: Olfactory receptor 8U8 (P0C7N1)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAHINCTQATEFILVGLTDHQELKMPLFVLFLSIYLFTVVGNLGLILLIRADTSLNTPMYFFLSNLAFVDFCYSSVITPKMLGNFLYKQNVISFDACATQLGCFLTFMVSESLLLASMAYDRYVAICNPLLYMVVMTPGICIQLVAVPYSYSFLMALFHTILTFRLSYCHSNIVNHFYCDDMPLLRLTCSDTRFKQLWILACAGITFICSVLIVFVSYMFIIFAILRMSSAEGRRKAFSTCSSHMLAVTIFYGTLIFMYLQPSSSHSLDADKMASVFYTVIIPMLNPLIYSLRNKDVKDALKKVIINRNHAFIFLKLRK
Protein: Malonyl-coenzyme A:anthocyanin 3-O-glucoside-6''-O-malonyltransferase (Dv3MaT) (Malonyl CoA:anthocyanin 3-O-glucoside-6''-O-malonyltransferase) (EC 2.3.1.171) (Q8GSN8)
Organism: Dahlia pinnata (Pinnate dahlia) (Dahlia variabilis)
Function: Catalyzes the transfer of the malonyl group from malonyl-CoA to pelargonidin 3-O-glucoside to produce pelargonidin 3-O-6''-O-malonylglucoside. Can also transfer the malonyl group from malonyl-CoA to cyanidin 3-O-glucoside, delphinidin 3-O-glucoside and quercetin 3-O-glucoside.
Interaction partners:
Sequence:
MDNIPNLTILEHSRISPPPSTIGHRSLPLTFFDIAWLLFPPVHHLYFYHFPYSKSHFTETVIPNLKHSLSITLQHYFPFVGKLIVYPNPHDSTRKPEIRHVEGDSVALTFAETTLDFNDLSANHPRKCENFYPLVPPLGNAVKESDYVTLPVFSVQVTYFPNSGISIGLTNHHSLSDANTRFGFLKAWASVCETGEDQPFLKNGSPPVFDRVVVNPQLYENRLNQTRLGTFYQAPSLVGSSSDRVRATFVLARTHISGLKKQVLTQLPMLEYTSSFTVTCGYIWSCIVKSLVNMGEKKGEDELEQFIVSVGCRSRLDPPLPENYFGNCSAPCIVTIKNGVLKGENGFVMAAKLIGEGISKMVNKKGGILEYADRWYDGFKIPARKMGISGTPKLNFYDIDFGWGKAMKYEVVSIDYSASVSLSACKESAQDFEIGVCFPSMQMEAFGKIFNDGLESAIAS
Protein: Probable carboxylesterase 18 (AtCXE18) (EC 3.1.1.1) (Q9LT10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylesterase acting on esters with varying acyl chain length.
Interaction partners:
- Non-specific lipid transfer protein GPI-anchored 4
- GDSL esterase/lipase At2g31550
- Expansin-A13
- S-formylglutathione hydrolase
Sequence:
MATDSQPNQKLTLPLKTRIALTVISTMTDNAQRPDGTINRRFLRLFDFRAPPNPKPVNIVSTSDFVVDQSRDLWFRLYTPHVSGDKIPVVVFFHGGGFAFLSPNAYPYDNVCRRFARKLPAYVISVNYRLAPEHRYPAQYDDGFDALKYIEENHGSILPANADLSRCFFAGDSAGGNIAHNVAIRICREPRSSFTAVKLIGLISIQPFFGGEERTEAEKQLVGAPLVSPDRTDWCWKAMGLNRDHEAVNVGGPNAVDISGLDYPETMVVVAGFDPLKDWQRSYYEWLKLCGKKATLIEYPNMFHAFYIFPELPEAGQLIMRIKDFVDERVASLSA