wanglab/gogpt-training-data huggingface dataset:
Protein: Cation transporting P-ATPase (EC 3.6.3.12) (Q8I461)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- non-specific serine/threonine protein kinase
- DnaJ protein, putative
Sequence:
MARFCKSDKLLINHRELKYICLFYIILLFCFFLWCIFKKYHENRINRKHKRKGSDSSHKNEKTEFFNYIYESYNDNDDVIIRQEGYKNSLCGFLLKNISIVLYLLTHFIIILLIGNEYCIKENGEILWNDRAFVFFIFLLLCFIITYGILTVRKHMHSFFIKPSLLKDSDYVLVYTKNEDYTNSYKNIFKESYVYITNVFIKWNKKIYKYSCKYIKLLHYYQMNAKSFFFFISTDKKKKKNDYIKNSYHDDDLDDDDIQNKDNNNYYYSNIYKKNSYYNNSFHKKSISNQYSNKRLSRNSLYTKKVLRDQENNLGYYDQDQNEINKMNSIDHIYNIDSLNVIDQGNDKNYDNEEKEINKKYPFNRNDEYGDEYGDEYGDEYGNKYGNKYGNKYDDKYGNKYDDKYDDKYDDKYDDKYDDKYDDKYDDKYDDKYDDKYDDNIVWGSKRFSNKKKKKGKKKRKNEMVTSAQTNREYIENNLKVHKVKVRINEKNVRYFFFRSMKYVYNEEKDGFYNISHSIEEKVKNLDFNYILKKGGLNNNEIINNINEYGYNNIHLEFYSFFKNLKRELLDGIYMFQLFISYKNFFWKEIITSLIWMIISILSVIKKIFKNQKNKKEIYENIQANNNTFVTVYRNSIVQQIPSNNLTIGDIIIINSKMTLPCDCLLLTGNVLVDESLLTGESRPMKKICLSSSKANSFNSYHTTSNERNTQNSKNDKYDRYQEGEEEEEYEEDHSSIHIDKKKNKKKKNNKKKKKSQINNGSKKYVDTQKMDNNKNNIYNKNNIYNNDNNIYNNDNNNNNNNNNIDTYDEGYDHTPFRKQNNDNKKCSVNNFNTNNILYAGTDVISTLNFTENIYAIVINVSIYTYKGKYMQNVLFPNPLLFKYDSQLPIVFIFTIMFSFVCLYFQIRYLGLNMTSIFYTIGTLSQILPVWTPVVLNIGLNISTNRLKKEKDICCIAPSRIPICGKIRVFFFDKTGTLTDHKIEFSGVHFCNNILNEKKKSISNSVNNIYPNKLLSDDDLKQIKNQTSLLNVSKTLKSIFTKNAKSNEKHKQLSKDMKKEAQNKEYQINSVELNNFMHGNHVDILPIENKENNEYNKIHTLDDVTLNHDNVIHHIDSLMPNHDDNNIHAHHNHVLYNNKYNNETSLKSPNGFQSMKSHMPMNKNEYNSLQEKREPTHNNDNNNDNNNNDNNNDNNYNYIYAIEDIRMDSMDNTNANDTINDEKDNEIYEEKQNNDVLYNLNEKEQLIDDNNMNEIKKTVYKEHFENYNTNDEPNTEEKINMDNYEELNNDHNNDHNNDHSNDHNNDHNNDHNNDHNNDLNNDHNNDHNNDHNNDHNNDHNNDHNNDHNNDHNNDHNNNNNYNNEFNYNDNHHLQYVGIDGVREDSFVMDQRNIQNDYDEKNGDDNHTYNTSFDISNVHNNYHNNNNNNNNHVDYVNYDYNNHAYENRNTQNKYFNESNSSMNSITSLLYNSKLMWTNKVTLNNTPSNYHLLIYALAGCSCVYYDNNNIYGNEIDKRLCEATEMKITNYINDDNVNIKKISLKINNNTYKSFDVLKTYEFDYYTKISTTLTYGNFDFKEKKYIVFSKGSFDKIYMKCIKNEELYFFKKKEQEYSKNGFYVIALAFKIISNMKHEHILDLPRQLLEKDMNFLSLIMFNNHIKKDASMVIQTLKGSSIRPVILTGDNAYNCLYVGNKIGLFNNVNFYESFFSLNMNSNINNKYINNKYINNNNKNNIYLNELNTNNHLSNTKNINSSIHSNMSNMELNHDEMKHSPKSPASKFLSFENFFKSGKKKNIKNNNKTDNENNYEDDNVMHNQSDYQYDHLLTPGTEHLDGFKNNETQKKEKHIYESLDKSQKLNETSKYIPGNAANYTTYSEFNHKYDQHKYDMNNEFSNDENSALIPHHVKEKNKRNKKKRSHIINTLINDNISDDENNSVYSQSHIFFNEQKLSISIINEEEEQKSDENIIVYGYLLNDELIFVNVHNEKRINKNVVLFKDIYKEIILTGEAYTFIRYHVFQIKTPDEDFDSEELEEYKNFLLRIRIFSRLTPNNKIEVIRDFIKFDYISGMCGDGSNDCGALKISHAGLALSNLDTSVVSPFSSKNENLKSVIDILREGRACLVTSINCYKYMLLYGFMISFIKILLFMNAHAVMSEYGYLFFDNVILLLLAKSMTLSKPACKLKTQTPTSSIIGAQTILSLLCTLLVNFFFLYSIIFYFLPINNLPSSYQANSSAPKSSWWLMSDNYESFLACIWFCFQIVNSALILTFGGKYRKPIFTNHTFMAYYVLINSFLFYLTVGGPNRLTCLFRMNCNDEISKITKFKFLELISYSASGLSFYGPHGHNILSTGLKIKFLLLNFINIAVNIFISKYILCESLYNVVRRFFNFQNRKVPI
Protein: Pheromaxein A subunit (Q863D3)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRLSLTVLLVTLALCCYEAHGIVCRALVKEFSAFLWKPDEIYKPELELFGAPPEAVDAKMKVKQCANGISFKKKILLTKTLVEILVKKCGFEDVKTLFPDISLGLSASVFK
Protein: Serine/threonine-protein kinase PknA (EC 2.7.11.1) (P9WI83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibition of processing of pre-PrcB and assembly of the proteasome complex, and thereby enhances the mycobacterial resistance to H(2)O(2); PknA thus plays an important role in the oxidative stress response by impeding the formation of holo-proteasome in M.tuberculosis under H(2)O(2) stress. Shows a strong preference for Thr versus Ser as the phosphoacceptor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21829358}; Single-pass membrane protein {ECO:0000269|PubMed:21829358}. Note=The majority of the cells displays PknA expression at the membrane perimeter along the length of the cell, whereas a minor population shows PknA to localize at either or both poles (uni- and bipolar; 16 and 14%, respectively) and occasionally to both the poles and the midcell (12%). {ECO:0000269|PubMed:25713147}.
Interaction partners:
- Serine/threonine protein phosphatase PstP
- Peptidoglycan D,D-transpeptidase PbpA
- Serine/threonine-protein kinase PknB
- Peptidoglycan glycosyltransferase RodA
- FHA domain-containing protein FhaB
- FHA domain-containing protein FhaA
- Glycogen accumulation regulator GarA
- Cell wall synthesis protein Wag31
- Cell division protein FtsZ
- UDP-N-acetylmuramate--L-alanine ligase
Sequence:
MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRALLWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWTERGETRHSGLQSWVVPPTPHSRASLARYEIAQ
Protein: Protein bride of sevenless (P22815)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a ligand for sevenless tyrosine-kinase receptor during eye development.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein sevenless
Sequence:
MKVMDALQSGRRKPLPVALLCILVTVFCVLECHGADLTSPTKKSAPLRITKPQPTSQQAKPISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEICLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEIGIRAISIDNASLAENLLIQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNEFMEAARQEHMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAVELDATPTALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLLLMRKLGTAMNFQMYQKKVLTLDKITGESRTELREIASQNFVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRYPFLFDGESVMFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGGFLSHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCENIYYGRWLWGLLAYDFALLCCVGALIPSIYRSQRNYREGILIVIGSVLIMVIWVAWIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIAQALPSLTSLAFAQNNQYSSEQSVYECVNPAMRHCSQDEVNHQSPSEIPTLPLRGGGPRRQQFFANLRQANANINPQRPPPRPQQSPSRSSVSSLPPSPDHNKITRF
Protein: Putative F-box/LRR-repeat protein At5g02930 (Q9LYZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRFKQPSRRDRPVMFKRSKNVSVDVGVDSISDLPDAVLQHIFSYIPTELAIRTSVLSKRWRHVWSETPHLSFEWLKVSPKLINKTLASYTASKIKSFHLCTRYSYEADTHHVNSSIEFAMSHNVDDLSLAFRRCSPFYNFDDCFYTNSSLKRVELRYVDLMPRCMVSWTSLKNLSLTDCTMSDESFLEILSGCPILESLSLKFCMSLKYLNLSKSLRLTRLEIERISYIRAPMLSMQIVAPYIHYLRLRDSEAHCTFVDVSSLTEANVDVSTFHPRTCYHDFDPLDPHDLLVMVQTMLKTFQKVEKLTLGVNLLQMLSLSKIPSLPLPMLKVKTLTLETMIIRSVVPGIARLLQNLPGLKKITVYTTNPCNTEVEPCVNSYLDAQDLNPDQWWRLDDVVFPISSEYEVLKPEIMASFMELLLANTRTLETLVVELGSCVARSRFKELFQIALTLSHDKKVSIMLKRSNG
Protein: Small ribosomal subunit protein mS47 (3-hydroxyisobutyryl-CoA hydrolase, mitochondrial) (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) (O74802)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P28817}.
Interaction partners:
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS11m
Sequence:
MGLKLNISNDLKKSGFMLRQSLLKTSVSNFLSLNASSTMSRAFIRNPKFYSTSSNDTVLYESKNGARIFTLNRPKVLNAINVDMIDSILPKLVSLEESNLAKVIILKGNGRSFSSGGDIKAAALSIQDGKLPEVRHAFAQEYRLSHTLATYQKPVVALMNGITMGGGSGLAMHVPFRIACEDTMFAMPETGIGYFTDVAASFFFSRLPGYFGTYLGLTSQIVKGYDCLRTGIATHFVPKHMFPHLEDRLAELNTSDISKINNTILEFAEFASSSPPTFTPDVMDVINKCFCKNDTVDIIRALKEYASNTSALAEFAKSTVKTLYSKSPTSIAVTNRLIKSAAKWSISEAFYYDHIVSYYMLKQPDFVEGVNAQLITKTKNPKWSKSHEYHFKDLENYFKLPSEYNNGISFAAKGRRKTPLWNYKTYPYL
Protein: UPF0357 protein C1687.07 (O14068)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MASFHIIVSYVTVVLAIIIAITFAARRFWISRYRSIRYSPVENSFEADFNNGLNSSSFDIAQNILAQDTRAGLDEAATSQIRGLMKQLQCSFDQARLIYIRKVMSDNNVDSTGMPLDNKAVTKL
Protein: Prostate and testis expressed 11 (Secreted TFP/Ly-6/uPAR protein PATE-P) (B3GLJ6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Prostate and testis expressed 7
- Prostate and testis expressed protein 3
- Prostate and testis expressed 10
- Prostate and testis expressed protein 13
- Prostate and testis expressed protein 4
- Prostate and testis expressed 5
- Prostate and testis expressed protein 2
Sequence:
MGKHVLQLLLVLSLLVMSLQALTCITCDRMNSRRICEGKEGCCQARPGEKCASFITLKDGKIQFGSQRCADLCFTGTVMIGDKTVKMNCCNNKSFCNKL
Protein: Sulfhydryl oxidase (EC 1.8.3.2) (H3BRD2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
NLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSPVAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKR
Protein: Zinc finger CW-type PWWP domain protein 1 (Q9H0M4)
Organism: Homo sapiens (Human)
Function: Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6IR42}. Chromosome {ECO:0000250|UniProtKB:Q6IR42}.
Interaction partners:
- Sodium/potassium/calcium exchanger 4
- Cas scaffolding protein family member 4
- Thioredoxin domain-containing protein 3
- Phospholipid-transporting ATPase ABCA7
- Fermitin family homolog 2
- Abnormal spindle-like microcephaly-associated protein
- Dual specificity protein kinase TTK
- CD2-associated protein
- Sortilin-related receptor
- Ras and Rab interactor 3
Sequence:
MMTTLQNKEECGKGPKRIFAPPAQKSYSLLPCSPNSPKEETPGISSPETEARISLPKASLKKKEEKATMKNVPSREQEKKRKAQINKQAEKKEKEKSSLTNAEFEEIVQIVLQKSLQECLGMGSGLDFAETSCAQPVVSTQSDKEPGITASATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKKSNRLTLSKRKKEAHEKVEKTQGGHEHRQEDRLKKTVQDHSQIRDQQKGEISGFGQCLVWVQCSFPNCGKWRRLCGNIDPSVLPDNWSCDQNTDVQYNRCDIPEETWTGLESDVAYASYIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQELSLELSVMKKRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNGSNSNGERKDLQLSGLNSPGSCLEKKEKEEELEKEEGEKTDPILPIRKRVKIQTQKTKPRGLGGDAGTADGRGRTLQRKIMKRSLGRKSTAPPAPRMGRKEGQGNSDSDQPGPKKKFKAPQSKALAASFSEGKEVRTVPKNLGLSACKGACPSSAKEEPRHREPLTQEAGSVPLEDEASSDLDLEQLMEDVGRELGQSGELQHSNSDGEDFPVALFGK
Protein: isochorismatase (EC 3.3.2.1) (E0SLE5)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- Chrysobactin synthetase cbsF
- Nonribosomal peptide synthetase
- Dimodular nonribosomal peptide synthetase
- isochorismate synthase
- 2,3-dihydroxybenzoate-AMP ligase, chrysobactin biosynthesis
- Indigoidine synthase
- 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
- Isochorismate synthase MenF
- MbtH-like protein
- Ferric chrysobactin binding proteinpermease periplasmic component
Sequence:
MAIPKLNAYPLPGVEHLPVNKVNWPVDPTRAALLIHDMQNYFLNFWGENSPLTEQLIANVARIRQACRQQGIPVFYTAQPNQQSDADRALLNDMWGPGLNRHPEQQQITAALTPNADDTVLVKWRYSAFHRSDLEQRLNAAGRDQLIICGVYAHIGCLTTATDAFMRNIKPFMIADALADFSQEEHLMALRYTAGRCGRVLTSEQLLDALAPQTDDGLARLRAELLPLLDDDDEIGDDDNLLDYGLDSVRIMSLVTRWRQQGHDLDFVALVKNPTLRHWHQLLSQPQREEA
Protein: Photosystem II 10 kDa polypeptide, chloroplastic (P27202)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Associated with the oxygen-evolving complex of photosystem II.
Subcellular location: Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Interaction partners:
- Oxygen-evolving enhancer protein 3-1, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem I reaction center subunit N, chloroplastic
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem II reaction center W protein, chloroplastic
- Photosystem I reaction center subunit III, chloroplastic
- Oxygen-evolving enhancer protein 3-2, chloroplastic
- Chlorophyll a-b binding protein 3, chloroplastic
Sequence:
MAASVMLSSVTLKPAGFTVEKTAARGLPSLTRARPSFKIVASGVKKIKTDKPFGINGSMDLRDGVDASGRKGKGYGVYKYVDKYGANVDGYSPIYNENEWSASGDVYKGGVTGLAIWAVTLAGILAGGALLVYNTSALAQ
Protein: Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)] (P20871)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
Function: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
Subcellular location: [Surface protein gp120]: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. {ECO:0000255|HAMAP-Rule:MF_04083}.; SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. {ECO:0000255|HAMAP-Rule:MF_04083}.
Interaction partners:
Sequence:
MRVKGIRKNYQHLWKGGILLLGTLMICSAVEKLWVTVYYGVPVWKETTTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLENVTEDFNMWKNNMVEQMQEDVINLWDQSLKPCVKLTPLCVTLNCKDVNATNTTSSSEGMMERGEIKNCSFNITKSIRDKVQKEYALFYKLDVVPIDNKNNTKYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGKGQCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEKVVIRSDNFTDNAKTIIVQLNESVKINCTRPSNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNISRAQWNNTLKQIVEKLREQFNNKTIVFTHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNDTEKSSGTEGNDTIILPCRIKQIINMWQEVGKAMYAPPIKGQIRCSSNITGLLLTRDGGKNESEIEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHMLQLTVWGIKQLQARVLAVERYLKDQQLMGIWGCSGKLICTTAVPWNTSWSNKSLDSIWNNMTWMEWEKEIENYTNTIYTLIEESQIQQEKNEQELLELDKWASLWNWFGITKWLWYIKIFIMIVGGLIGLRIVFSVLSIVNRVRQGYSPLSFQTLLPATRGPDRPEGIEEEGGERDRDRSGQLVNGFLALIWVDLRSLFLFSYHRLRDLLLTVTRIVELLGRRGWEILKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRIIEVVQRVYRAILHIPTRIRQGLERALL
Protein: 2-oxoglutarate oxidoreductase subunit KorB (EC 1.2.7.3) (Alpha-ketoglutarate oxidoreductase subunit beta) (KG oxidoreductase subunit beta) (KGO subunit beta) (KOR subunit beta) (O53181)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR likely represents an important step in intermediary metabolism in vivo. KOR-dependent decarboxylation of KG also appears to be an important source of CO(2) in M.tuberculosis metabolism.
Interaction partners:
- 2-oxoglutarate oxidoreductase subunit KorA
- Probable molybdenum cofactor guanylyltransferase
- Phosphate acetyltransferase
- Isocitrate dehydrogenase 2
- Pyruvate kinase
- Succinate--CoA ligase subunit alpha
- Succinate--CoA ligase subunit beta
- Putative citrate synthase 2
- Putative malate oxidoreductase
- Isocitrate dehydrogenase 1
Sequence:
MTRSGDEAQLMTGVTGDLAGTELGLTPSLTKNAGVPTTDQPQKGKDFTSDQEVRWCPGCGDYVILNTIRNFLPELGLRRENIVFISGIGCSSRFPYYLETYGFHSIHGRAPAIATGLALAREDLSVWVVTGDGDALSIGGNHLIHALRRNINVTILLFNNRIYGLTKGQYSPTSEVGKVTKSTPMGSLDHPFNPVSLALGAEATFVGRALDSDRNGLTEVLRAAAQHRGAALVEILQDCPIFNDGSFDALRKEGAEERVIKVRHGEPIVFGANGEYCVVKSGFGLEVAKTADVAIDEIIVHDAQVDDPAYAFALSRLSDQNLDHTVLGIFRHISRPTYDDAARSQVVAARNAAPSGTAALQSLLHGRDTWTVD
Protein: RNA polymerase sigma factor RpoS (Sigma S) (Sigma-38) (P45684)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00959}.
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta'
- RNA-binding protein Hfq
- DNA-directed RNA polymerase subunit omega
- RNA polymerase sigma factor FliA
- histidine kinase
- Translational regulator CsrA
- RNA polymerase sigma-54 factor
- GTP pyrophosphokinase
Sequence:
MALKKEGPEFDHDDEVLLLEPGIMLDESSADEQPSPRATPKATTSFSSKQHKHIDYTRALDATQLYLNEIGFSPLLTPEEEVHFARLAQKGDPAGRKRMIESNLRLVVKIARRYVNRGLSLLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLPIHVVKELNVYLRAARELTHKLDHEPSPEEIANLLEKPVAEVKRMLGLNERVTSVDVSLGPDSDKTLLDTLTDDRPTDPCELLQDDDLSESIDQWLTELTDKQREVVIRRFGLRGHESSTLEEVGQEIGLTRERVRQIQVEALKRLREILEKNGLSSDALFQ
Protein: Mating-type switching protein swi5 (DNA repair protein swi5) (Q9UUB7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.
Interaction partners:
- Swi5-dependent recombination DNA repair protein 1
- DNA repair protein rhp57
- DNA repair protein rhp55
- Mating-type switching protein swi2
- DNA repair protein rhp51
- ATP-dependent DNA helicase hus2/rqh1
- Meiotic recombination protein dmc1
Sequence:
MEKSQLESRVHLLEQQKEQLESSLQDALAKLKNRDAKQTVQKHIDLLHTYNEIRDIALGMIGKVAEHEKCTSVELFDRFGVNGSE
Protein: TSET complex member tstC (Protein TCUP) (Q54E64)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MTIVGLVIQQHDGTILFQNVREYLSLDKAHLAAKAFKNQISSYDENFITKGSISHLTGSVVVLNMYRVYYMILNELFILAISQANDNPFEGSIYLARAKRVLWSVSKDFTTTQINKKYTEVYFALERVLFGEDGVEVLSQKISEVSPHQPPHYNTHHHTSTPSVAPSFITGGSTTPPPITIFGRLIEPNQSNSLSNSISNSNSNNNNNNNNDSININSINSNIYQTTVPLTLSNVLNSSNFNNNNNNNNNNNNNNNNSNNSLNNSNSNSNIISPSSSSGNLSSFNNNNNNEEYNNYNNNYNSLDNSYSLQFESLMRLEQSNIPEKIFTQPNTLPKIDKHIYDPPQTIKWGNPSVSHIGSSASSTRVTNRIMFTLRHPNAGKEAKEKEKEKENEFKEQQEINNMNNNNNGANGNSGGSGNVIIGSAAAGSASSKSSPSTSPLSSSYNPSSPETSENSFSATPISDSNSLKNSIDNNNNNNNNNNNNNNSGDTPETPKRKFSLSMGTFNNSKSSLSTSNSNISTPDNGASSPLASSTSGSASSAAAPPPVPLTNSAKTKMNFLNF
Protein: Protein MPE1 (P35728)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
Subcellular location: Nucleus {ECO:0000269|PubMed:12819204}.
Interaction partners:
- Cleavage factor two protein 2
- Endoribonuclease YSH1
- Protein CFT1
- RNA end formation protein 2
- Pre-mRNA polyadenylation factor FIP1
- mRNA 3'-end-processing protein YTH1
- Serine/threonine-protein phosphatase PP1-2
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Polyadenylation factor subunit 2
- Uncharacterized protein YJR141W
Sequence:
MSSTIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDTEEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTNSDPNFEGKRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVESDFVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK
Protein: Phosphoprotein (Protein P) (P24698)
Organism: Newcastle disease virus (strain Beaudette C/45) (NDV)
Function: This protein is probably a component of the active polymerase. It may function in template binding.
Interaction partners:
Sequence:
MATFTDAEIDELFETSGTVIDNIITAQGKSAETVGRSAIPHGKTKALSAAWEKHGSIQPPASQDTPDRQDRSDKQPSTPEQATPHDSPPATSADQPPTQATDEAVDTQLRTGASNSLLLMLDKLSNKSSNAKKGLWSSPQEGNHQRPTQQQGSQPSRGNSQERPQNQVKAAPGNQGTDANTAYHGQWEESQLSAGATPHALRSRQSQDNTLVSADHVQPPVDFVQAMMSMMEAISQRVSKVDYQLDLVLKQTSSIPMMRSEIQQLKTSVAVMEANLGMMKILDPGCANVSSLSDLRAVARSHPVLVSGPGDPSPYVTQGGEMALNKLSQPVPHPSELIKSATACGPDIGVEKDTVRALIMSRPMHPSSSAKLLSKLDAAGSIEEIRKIKRLALNG
Protein: Tyrosine-protein phosphatase 99A (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 99A) (DPTP99A) (P35832)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a key role in signal transduction and growth control. May have a role in the establishment of the intersegmental and segmental nerves.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Midkine and pleiotrophin 1, isoform A
- Tyrosine-protein phosphatase 69D
- Contactin
- carbonic anhydrase
Sequence:
MPRPQHHALLRAMLKLLLFASIAEHCATALPTNSSNSPSSPSPFTVASLPPTTASSSSSPAVISTSSFDRNLADLVNPEAETSGSGWESLETEFNLATTVDSSTQKTAKEPVLGTAATSIEQQDQPPDVPATTLAFANAFPVPVAGEMGNGNGNYNDATPPYAAVDDNYVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTTATPDLYSKICSNGNVPQHVILQQQQLHMLQLQQQHLETQQQQQQQQQQQQQQQQTALNETVSTPSTDTNPSLLPILSLLPPTVAPLSSSSSTTPPTPSTPTPQPPQTIQLSSHSPSDLSHQISSTVANAASPVTPATASASAGATPTTPMTPTVPPTIPTIPSLASQNSLTLTNANFHTVTNNAADLMEHQQQQMLALMQQQTQLQQQYNTHPQQHHNNVGDLLMNNADNSPTASPTITNNNHITNNNVTSAAATDAQNLDIVG