wanglab/gogpt-training-data huggingface dataset:
Protein: Developmental protein SEPALLATA 2 (Agamous-like MADS-box protein AGL4) (P29384)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor. Functions with SEPALLATA1/AGL2 and SEPALLATA3/AGL9 to ensure proper development of petals, stamens and carpels and to prevent the indeterminate growth of the flower meristem. Forms a heterodimer via the K-box domain with AG, that could be involved in genes regulation during floral meristem development.
Subcellular location: Nucleus.
Interaction partners:
- Floral homeotic protein AGAMOUS
- Agamous-like MADS-box protein AGL97
Sequence:
MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVSLIVFSNRGKLYEFCSTSNMLKTLERYQKCSYGSIEVNNKPAKELENSYREYLKLKGRYENLQRQQRNLLGEDLGPLNSKELEQLERQLDGSLKQVRCIKTQYMLDQLSDLQGKEHILLDANRALSMKLEDMIGVRHHHIGGGWEGGDQQNIAYGHPQAHSQGLYQSLECDPTLQIGYSHPVCSEQMAVTVQGQSQQGNGYIPGWML
Protein: Plakoglobin (Q6VAH9)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}.
Interaction partners:
Sequence:
QALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDGEGASAPLMELLHSRNEGTATYAAAVLFRIP
Protein: Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (A0A060X9D7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ig-like domain-containing protein
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Endothelin-3
- Neuropeptide Y
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-13
- Uncharacterized protein
Sequence:
MASPLNSACSVGLGDTNGSTSGLSLPCNQSVSSLQLAPYSPESTALFATAITLMVVFTIVGNILVIIAVLTSHALRGPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFKSLWCEIYLALDVLFCTSSIVHLCAISLDRYLSISRVTYSRQRTPMRIKASIVVVWLISAIISFPPLLSLNKSEPGGEGSERGPQCQLNDERWYILYSTVGSFFAPCLIMILVYMRIYQIAKQRTQNPPGEPRKDGVGSMPHKTTSVRPPTLAVTPSPSPDQANETPSPHIPTTQNLLHAPVLSLAPTPTTTSPPTSPLDPSPSLKKYNNNMDSSNSSDSDMENEEGGRTGVNNPSMAGSAGIHSPATIQKYRDIIATSKGARLVAGRRSKPESTPGAARRKAMVNREKRFTFVLAVVIGVFVVCWFPFFFSYSLQAICPETCSLPDPLFKFFFWIGYCNSCLNPVIYTIFNQDFRKAFKKILCKNTKGTFF
Protein: Guanine nucleotide-binding protein subunit alpha (Q71RI7)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Metabotropic glutamate receptor 1
- 5-hydroxytryptamine receptor 2B
- G protein subunit beta 1
- 5-hydroxytryptamine receptor 2A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Endothelin-1 receptor
- 5-hydroxytryptamine receptor 2C
- Type-1 angiotensin II receptor
Sequence:
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSEEDKKGFTKLVYQNIFTAMQSMIRAMETLKILYKYEQNKANAVLIREVDVEKVMTFEQPYVSAIKTLWNDPGIQECYDRRREYQLSDSAKYYLSDVDRIATPGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Protein: Mating-type-like protein A2 (MTLa2 protein) (Q71U11)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of a-specific mating genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mating-type-like protein A1
- Uncharacterized protein
- Oxysterol-binding protein-like protein OBPa
- HECT-type E3 ubiquitin transferase
Sequence:
MPYTFNFPKSQSSFKYSIKSLTNSRSFPMISIYVTPQSTPKFINNQSIDKMTVLSSFRSRNSFIIARSILSKLLRKNKADFKKVSKSVSLLWGSVDNSFKNYFEYLSILESQWHDKKSSNLNPISSTRTTSELNYIELCSSIYNQSRKHPRSVQGNKAKFRLYKNVSKKSNRKPRRLKNGFKVSRSTINCSYGIYTEDVFQ
Protein: Carbonic anhydrase (CA) (Cam) (EC 4.2.1.1) (P40881)
Organism: Methanosarcina thermophila (strain ATCC 43570 / DSM 1825 / OCM 12 / VKM B-1830 / TM-1)
Function: Reversible hydration of carbon dioxide. Important for growth on acetate. As a probably extracellular enzyme, it may support a H(+)/CH(3)COO(-) symport mechanism and/or conversion of CO(2) to HCO(3)(-), removing excess CO(2) produced by growth on acetate (Probable).
Subcellular location: Secreted {ECO:0000305|PubMed:8041719}. Note=When isolated from M.thermophila. {ECO:0000269|PubMed:8041719}.
Interaction partners:
Sequence:
MMFNKQIFTILILSLSLALAGSGCISEGAEDNVAQEITVDEFSNIRENPVTPWNPEPSAPVIDPTAYIDPQASVIGEVTIGANVMVSPMASIRSDEGMPIFVGDRSNVQDGVVLHALETINEEGEPIEDNIVEVDGKEYAVYIGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGNNCVLEPRSAAIGVTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVVYVNVHLAEGYKETS
Protein: AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) (O75843)
Organism: Homo sapiens (Human)
Function: May function in protein sorting in late endosomes or multivesucular bodies (MVBs).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11333915, ECO:0000269|PubMed:9762922}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:11333915}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9733768}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:16867982}; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).
Interaction partners:
- AP-1 complex subunit sigma-2
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit beta-1
- AP-1 complex subunit mu-2
- AP-1 complex subunit mu-1
- AP-1 complex subunit sigma-3
- Synergin gamma
- AP-1 complex subunit gamma-1
- AP-2 complex subunit beta
- AP-4 complex subunit beta-1
Sequence:
MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLPVESWQ
Protein: Toxin Ct28 (Potassium channel toxin alpha-KTx 2) (P0DUI4)
Organism: Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Function: Blocks voltage-gated potassium channels.
Subcellular location: Secreted {ECO:0000269|PubMed:23840487}.
Interaction partners:
Sequence:
MKAFYGILIILLFCSMFKLNESTTINVKCTSPKQCLKPCKDLYGPHAGAKCMNGKCKCYNNG
Protein: Tachykinin-3 [Cleaved into: Neurokinin-B (NKB) (Neuromedin-K)] (P08435)
Organism: Rattus norvegicus (Rat)
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Neuromedin-K receptor
- Substance-K receptor
- Substance-P receptor
- Protachykinin-1
- KiSS-1 receptor
- Gonadotropin-releasing hormone receptor
- Metastasis-suppressor KiSS-1
- Progonadoliberin-1
- Tachykinin-4
- Pro-FMRFamide-related neuropeptide VF
Sequence:
MRSAMLFAAVLALSLAWTFGAACEEPQEQGGRLSKDSDLSLLPPPLLRRLYDSRSISLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPADVVEENTPSFGVLK
Protein: Uncharacterized protein tam1 (Transcripts altered in meiosis protein 1) (G2TRJ4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein C29A10.17
- Uncharacterized protein C1778.05c
- Uncharacterized protein C23D3.16
- Cx9C motif-containing protein 4, mitochondrial
- Cytochrome c oxidase assembly factor 3, mitochondrial
- GTP-binding protein gtr1
- Uncharacterized protein tam5
- Uncharacterized protein tam6, mitochondrial
- Folliculin-like protein bhd1
- Mitochondrial import protein 2
Sequence:
MSVSQQLSELASKEKTVLYVADQNLEEVLCFPESTDRTTLVQLTDACLHANELAKHLEFGKPLSITNQYSRGSCVLQIAKEKKDGSGMVVSTTIAAHNALRGALKCSNALDQVISQL
Protein: Putative U3 small nucleolar ribonucleoprotein (Putative U3 small nucleolar ribonucleoprotein protein; 1537-3735) (Putative U3 small nucleolar ribonucleoprotein protein; 73469-75667) (Ribosomal RNA processing Brix domain protein) (Q9S826)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transducin family protein / WD-40 repeat family protein
- Bystin
- Uncharacterized protein At3g06530
- Protein SLOW WALKER 1
- F18K10.11 protein
- Protein TORMOZ EMBRYO DEFECTIVE
- Nucleolar protein
- AT1G07840 protein
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Probable U3 small nucleolar RNA-associated protein 11
Sequence:
MQRRLVRLKKEYIYRKSLEGDERKVYEQKRLIREALQEGKPIPTELRNVEAKLRQEIDLEDQNTAVPRSHIDDEYANATEADPKILLTTSRNPSAPLIRFTKELKFVFPNSQRINRGSQVISEIIETARSHDFTDVILVHEHRGVPDGLIISHLPFGPTAYFGLLNVVTRHDISDKKSIGKMPEQYPHLIFNNFTTQMGQRVGNILKHIFPAPKLDAKRIVTFSNQSDYISFRNHVYDKGEGGPKSIELKEIGPRFELRLYQVKLGTVEQNEAEIEWVIRPYMNTSKKRKFIGE
Protein: Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog) (O75648)
Organism: Homo sapiens (Human)
Function: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15509579, ECO:0000269|PubMed:15944150, ECO:0000269|PubMed:16513084, ECO:0000269|PubMed:16826519}.
Interaction partners:
- 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial
- 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial
- Cysteine desulfurase
- tRNA dimethylallyltransferase
- Pseudouridylate synthase 1 homolog
Sequence:
MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL
Protein: Transcriptional regulator EFH1 (EFG1 homolog 1) (Q59P39)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00630}.
Interaction partners:
- cAMP-dependent protein kinase
- Enhanced filamentous growth protein 1
- cAMP-dependent protein kinase
- Transcription activator TEC1
- Suppressor of ferric uptake 1
Sequence:
MNGIMTTSSHSNFYNQDLVGAPSSSDHIPGPSSQDQPTNNNSPQHHHQHDQSQTTHQNHPLNQPIHHHPTQQNQSESQQSRQSHHLQQQQQQQQQQQQNQHNQQNLASSSTSYEMPSIYQQFTGSYQQTRVPKNFLLENANYYTLQPGFPLVQAADYYSTPTTTSANDYQNSTINSIISPSFQMGSVSTPDTQNSSIRSKQQQQHSYQQQQPQQLSQSQHQSQVPDIFYTQGGTIGGYVTTKQQQKEFSRKTSGDQTLVPQTNSKLQQQISETSYSQQQQQQQSPPTPQKQQQQQHYQHQTTQPYGGTGFMLYSQTGGPSSSPVAGNISIPTTIATTGQPNSQFQFTYGSPQQGSSSKTNQMYLYQRQQQQQQQHQQPQSQQMSQISQLSQQIPPQGSSKNISINSTPTKSRASSITTRSGRQSRSTSISSFIPQPDYPERVIRPKVATTRWDDENTNCYQVRARNILVSRREDTNYINGTKLLNVIGMTRGKRDGILKTEKIKNVVKVGSMNLKGVWIPFDRAYEIARNEGVDSLLYPLFVKNIKQYFLTKGHKLKSEDDEQEILEEGMTRQREEVRREGRSNGVGDFHNEEEEEIVGIQEDAGPNTAENDVPGDDEEEEDDDDDDDDDEEEGEQDDEEEEDGSSTSMSSSKNSESKLLETRDVIKSIVEEGDSTTGNVSEVKYVHEYLERSPQSTAIKEEDLYYGSSHNTPLTVHKTL
Protein: Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258) (Protein kuduk) (Transmembrane protein 258 homolog) (Q9VVA8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). In addition may regulates nuclear envelope (NE) architecture and nuclear positioning through the linker of nucleoskeleton and cytoskeleton (LINC)-dependent and -independent mechanisms.
Subcellular location: Nucleus outer membrane {ECO:0000269|PubMed:28716842}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:28716842}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:28716842}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Malectin domain-containing protein
- Putative oligosaccharyltransferase complex subunit CG9662
- Protein transport protein Sec61 gamma-1 subunit
- dolichyl-diphosphooligosaccharide--protein glycotransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Sequence:
MDVMQRYVSPVNPAVFPHLATVLLVIGTFFTAWFFIFVVSRKSSKESTLIKELLISLCASIFLGFGIVFLLLTVGIYV
Protein: Probable cation-transporting ATPase G (EC 7.2.2.-) (P9WPS7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv1993c
- HTH-type transcriptional regulator CmtR
Sequence:
MTTVVDAEVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGKVAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYASRSASNRKAGVVQKIIDWSTRTLSGVRRDVAAQPSGETSDACCDGEDNEDREPEQLWQVAKLRRAAFSGVLLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEGRVGVGTLMTIAALGAVALGELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGTETIVASTELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVGPGDEVFAGSINGLGVLQVGVTATAANNSLARIVHIVEAEQVRKGASQRLADCIARPLVPSIMIAAALIAGTGSVLGNPLVWIERALVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVALDKTGTLTANRPVVIDVATTNGATREEVLAVAAALEARSEHPLAVAVLAATQATTAASDVQAVPGAGLIGRLDGRVVRLGRPGWLDAAELADHVACMQQAGATAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGYQVTMLTGDNHATAAALAAQAGIEQVHAELRPEDKAHLVAQLRARQPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALDHARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAGRIKPLAGPPKTPDRTIPG
Protein: Large ribosomal subunit protein uL24 (60S ribosomal protein L26-B) (A0A1D8PCQ5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS9m
- Mitochondrial 54S ribosomal protein YmL8
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL22
Sequence:
MAKISQDVSSSRSKARKAYFTASSVERRVLLSAPLSKELRQQYNVKSLPIRQNDEVLVVRGSKKGSEGKVNSVYRLKFAIQVDKLQKEKSNGASVPINIHPSKVVITKLHLDKDRKALIQRKGGKAE
Protein: Early E1A protein (Early E1A 27 kDa protein) (P10541)
Organism: Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
Function: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity).
Subcellular location: Host nucleus {ECO:0000250|UniProtKB:P03255}.
Interaction partners:
Sequence:
MRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEMSLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGEELLPVDLDLKCYEDGLPPSDPETDEATEAEEEAAMPTYVNENENELVLDCPENPGRGCRACDFHRGTSGNPEAMCALCYMRLTGHCIYSPISDAEGESESGSPEDTDFPHPLTATPPHGIVRTIPCRVSCRRRPAVECIEDLLEEDPTDEPLNLSLKRPKCS
Protein: Zygote defective protein 9 (G5EEM5)
Organism: Caenorhabditis elegans
Function: Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes.
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10085292, ECO:0000269|PubMed:12011109, ECO:0000269|PubMed:12956952, ECO:0000269|PubMed:17666432, ECO:0000269|PubMed:9606208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10085292, ECO:0000269|PubMed:12011109, ECO:0000269|PubMed:12956952, ECO:0000269|PubMed:16971515, ECO:0000269|PubMed:17666432, ECO:0000269|PubMed:9606208}. Cytoplasm {ECO:0000269|PubMed:10085292, ECO:0000269|PubMed:12011109, ECO:0000269|PubMed:12956952, ECO:0000269|PubMed:17666432, ECO:0000269|PubMed:9606208}. Note=Cycles between cytoplasm and centrosome during mitosis in a cell cycle- dependent manner. Centrosomal recruitment requires tbg-1.
Interaction partners:
- Transforming acid coiled-coil-containing protein 1
- Kinetochore protein ndc-80
- Spindle-defective protein 5
- Calponin homology domain-containing protein
- Kinetochore protein Nuf2 homolog
- TPX2 domain-containing protein
- Aurora kinase
- Kinesin-like protein
- Microtubule End Binding Protein
- EB1 C-terminal domain-containing protein
Sequence:
MSNWDYLDEVDILPKLPPNFDELRESKKWQERKEALEALLKVLTDNERLSTKASYAELIGHLQMVLAKDANINCQALAAKCIGKFATGLRAKFSSFAGPLLPVIFEKMKEKKPMLREPLVDCSNEVGRTMQSLETGQEDILAALAKPNPQIKQQTALFVARQLDLVVPAKQPKGFIKAVVPVFGKLTGDADQDVREASLQGLGAVQRIIGDKNVKNLLGDASSDEGKMKKIGEYAEKSTASFAEEQAKNAPPVAPTSSTPSASAASGDPSGGTATAVVSSGAPVAEADPWDFLDAFDVLSKMPDGFDTNIESKKWQERKEALEGLLQLITANPKLDPKANYGALVERLQKVLEKDANINVAALAANCITGIANGLRTKFQPFAVSVTPIIFEKFKEKKPTLRDPLVACIDAVVATTNLEAVGEIVLAALGKPNPSIKTQTDLFLQRCFMKLNSQTMPKKTLKTLIPSLIKHSGDSDSEVREASYAAMGAMMRAIGEKPSLQLLADIASDNLKMSKIKEFHQKALDEAGPAEIAEMVKSIHKADAPPAAAPPKKTAPPKKQPEDEEVVEEEDEPLKPPPGDKKKKVPVKENEENEPPVVAPKAELLLSDNEDKKQRIKEEKQLKLVKWNFQAPTDEHISQLQTLLGNQAKVSLMSQLFHKDFKQHLAALDSLVRLADTSPRSLLSNSDLLLKWCTLRFFETNPAALIKVLELCKVIVELIRDTETPMSQEEVSAFVPYLLLKTGEAKDNMRTSVRDIVNVLSDVVGPLKMTPMLLDALKSKNARQRSECLLVIEYYITNAGISPLKSLSVEKTVAPFVGDKDVNVRNAAINVLVACFKFEGDQMWKAAGRMADKDKSLVEERIKRTGVKPGSGVVTSPPTGGPKILVPQQQGSVVRRPASRSRTREPEPEEVQSDTFTIRQDTMPPKTSSRYALRDDVFSSAMGRLDGTQVITPPQPVNGWSNNTFQMKRTNSSSSISSIDTSDQIQRSINNISSSLADVAQDAMFQVTYVLNQPEQRHLVDRRADLVFRASAAQLDLVIEEFNAGRDVSGTMDACTQMLFILMGGVETEHGLEPLNASPDTVKAIISSVLRCIIQIGNTESGYGMARSLNRLAMRLIYRVELSNLLCGLILAMTESLQMNTGITELVSKLSSKWCDELEKRRAQLRASDIVDSFNAFYVCALTELKMDISDSHILIVDNYLERVILQQGDVVLDAARRLSRPHMHLTSMINKILQMMRERKIDPIMPGTLEARMPQEDEAVVVRSGVQVSIDNILRDTSMAVKHIEQLNILIASSDRSWNEYMEYLKNNPMGELIKELVGECSRKKRIDFNLSHVVKSSMAVFKAMAATGPVQEEGRITPTDINRMDTMIVGTPLSRGDATITRARGNMIRPKRTTLSRDQMANIRHTLDRVKNH
Protein: Meiosis-specific protein HED1 (RED1 suppressor protein 1) (Q03937)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in regulation of meiotic recombination and repair of DNA damage. Inhibits RAD51-mediated recombination when the meiotic recombination machinery is impaired.
Subcellular location: Nucleus {ECO:0000269|PubMed:16818607}. Chromosome {ECO:0000269|PubMed:16818607}. Note=Localizes as foci on meiotic chromosomes.
Interaction partners:
- DNA repair protein RAD51
- Pachytene arrest protein SAE3
- DNA repair and recombination protein RAD54
- Meiotic recombination protein DMC1
Sequence:
MQQRSNRRSCSYIPLGVHNNAEKSLCTEVAPARKNKRSITTSPIVNINVVERRLFNLELEKQQLRAKNLSENTGGGSPNGGAYLDAKKGVREQDQYQGGPSKELDRLQPPPSMKKSPPRKKKSLKDLIYETNKTFYQVDSNKVKYKVGLSKKQLLPSKTVDN
Protein: Homeobox protein HMX1 (Homeobox protein H6) (Q9NP08)
Organism: Homo sapiens (Human)
Function: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPDELTEPGRATPARASSFLIENLLAAEAKGAGRATQGDGSREDEEEDDDDPEDEDAEQARRRRLQRRRQLLAGTGPGGEARARALLGPGALGLGPRPPPGPGPPFALGCGGAARWYPRAHGGYGGGLSPDTSDRDSPETGEEMGRAEGAWPRGPGPGAVQREAAELAARGPAAGTEEASELAEVPAAAGETRGGVGVGGGRKKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAASLSPPGAQRLVRVPVLYHESPPAAAAAGPPATLPFPLAPAAPAPPPPLLGFSGALAYPLAAFPAAASVPFLRAQMPGLV