wanglab/gogpt-training-data huggingface dataset:
Protein: Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66) (Q7K4H4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Large ribosomal subunit protein uL2
- 2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog
- HSPB1 associated protein 1
- Lysine-specific demethylase 3
- Large ribosomal subunit protein uL15
- Jumonji C domain-containing protein 5
Sequence:
MKKATTSAAAKSQGNSKMQKNANNGTAKDKKKPNLDKESNDSNSVSDMLAVTKDQEVHAFFSKLFDDDAGPSTSKKTQSGSAAAAKTADRKRRLQAEADANNNDTGKAGKLTKESEATQGARATKRKQARSLGLERTSPIQVNGAALACPLVRKSLPPGEANSCPQPPKKDPAAVNSLVKIIKAEPTEEGNNNNDEKETETIETHKADSVEEGRRVLQWILFPVQTKVFFKDFWEHTACLVQRSNPKYFQSMISFKMLDEILIRHHLDFTVNVDVTTYKNGKRETLNPEGRALPPAVWGFYSDGCSIRLLNPSTYLIRLRQVCTVLQEFFHCKVGANLYLTPPNSQGFAPHYDDIEAFVIQVEGRKRWLLYEPPKKADQLARISSGNYDQEQLGKPIIDEVLSAGDVLYFPRGAVHQAITEEQQHSLHITLSVYQQQAYANLLETLMPMVLKKAVDRSVALRRGLPLHTFQVLGNAYKGNDCGSRKQLVENVQKLVTNYLMPSEDDIDEAVDQMAKKFQHEALPPIVLPSEEVRTVHGARSDADEQGNCVCDYKFNKKTSVRLLRANILRLVTESDGSVRIYHHVDNGLDYCKYEPYFMEILPEEAKAVELLISAYPFYLTIDQLPLESSARKIEVATALWEHGLLMTEKPFK
Protein: Transcriptional activator, putative (B9WKI2)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Interaction partners:
Sequence:
MSANLQTRLENSLNDILKASGYIFEIINHNKKQSNLITGPNNELIQQSIIQQLSDHIQGFNDILDQTVSKFNDAKWCVAVMIENKQKLEEETERQKREAEARRLKEEMEAKKKAEEEAAAKAAAEARAKEEEARAAARAKEEEARAAAMAKMEEVAAKAKAAMEQEKKEKEALRKKQEEEEEAQRKKLEQQKRENQAPKFDNFDEFIGFDINDMPNGDETIDEDMLSNINYEDLGLDDPMQGSSSTLQAQSMSDTPIGKTSDKVANMDLDMNNLLENDESILDGLNMTLLDGGLDGDNSNNDNQVNEEFDVDSFLNQFGN
Protein: dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (EC 2.1.1.234) (Q9ZGH6)
Organism: Streptomyces venezuelae
Function: S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of desosamine, found in certain macrolide antibiotics such as erthyromycin, azithromycin, clarithromycin, and methymycin. Catalyzes the last step in the biosynthesis of dTDP-desosamine, i.e. the N,N-dimethylation of the 3-amino group of dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose.
Interaction partners:
Sequence:
MYEVDHADVYDLFYLGRGKDYAAEASDIADLVRSRTPEASSLLDVACGTGTHLEHFTKEFGDTAGLELSEDMLTHARKRLPDATLHQGDMRDFRLGRKFSAVVSMFSSVGYLKTTEELGAAVASFAEHLEPGGVVVVEPWWFPETFADGWVSADVVRRDGRTVARVSHSVREGNATRMEVHFTVADPGKGVRHFSDVHLITLFHQAEYEAAFTAAGLRVEYLEGGPSGRGLFVGVPA
Protein: Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1) (Q695T7)
Organism: Homo sapiens (Human)
Function: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:26240152}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18424768}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ACE2 on the apical membrane of cells lining villi of the jejunum, ileum and on kidney proximal tubules. {ECO:0000269|PubMed:18424768}.
Interaction partners:
- Angiotensin-converting enzyme 2
- Collectrin
- Proton-coupled amino acid transporter 2
- b
- Neutral amino acid transporter B
- Angiotensin-converting enzyme
- Amino acid transporter heavy chain SLC3A1
Sequence:
MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
Protein: Zinc-regulated transporter 1 (A0A1D8PMR6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:22761575}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- pH-regulated antigen PRA1
- Zn
- Csr1p
Sequence:
MKFTHLFFIGLLTKVYTETVTVLSTRSYRLATTESTPTDGTVYLTLTRQQSSSTSLNASTITTPPSNSSASVQTTAVTDCHFHNSVQYCVDGYGNEGSILPVPTNTNNLPTSYDGCHSHDGDTFCMDGDKEVQFVKLEDEDDEESSSSSGKKCHFHAGVEHCVDDNNHDAVTCERVKRDYDIPLRIGLLFVILVTSGIGSFGPIVLKQFVNLSQENYIIVIIKQFGTGIIISTAFVHLMTHAQLMWSNSCLKIKYEGTGASITMAGIFIAFIIEYIALRIVNARDTGKVDKKEIEETSSNEQSLHGISVNDKISVMILEAGIIFHSILIGITLVVTDDVYFITLFIVIVFHQFFEGLALSSRIISITNASLSTKLVMALMFALITPIGMAIGIGVLNKFNGNDPSTLIALGTLDSFSAGVLLWTGLIEMWSHDWLHGHLRNSSFVKTTVALVSLILGMLLMSLLGNWA
Protein: Sperm-associated microtubule inner protein 10 (Testis-expressed protein 43) (Q6ZNM6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D9I1}. Note=Localizes at the ribbon and inner junction (IJ) between A- and B-tubules of the DMTs. {ECO:0000250|UniProtKB:Q9D9I1}.
Interaction partners:
Sequence:
MASGKDTCPTLPKLTNNCSDESLYKSANKYEEIHLPRFSLKQGMIPRRYVMPWKENMIFRNVNLKQAEVCGIHTGPLEDSLFLNHSERLCHGEDRKVVFQKGPPEIKIADMPLHSPLSRYQSTVISHGFRRRLV
Protein: Homeobox protein Meis1 (O00470)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Pre-B-cell leukemia transcription factor 1
- Homeobox protein Hox-A9
- Homeobox protein Meis2
- Homeobox protein Hox-B13
- Homeobox protein DLX-3
- Nuclear pore complex protein Nup98-Nup96
- Homeobox protein Hox-A7
- Putative nucleotidyltransferase MAB21L1
- Homeobox protein Hox-A10
- Cyclic AMP-responsive element-binding protein 1
Sequence:
MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
Protein: Leukocyte associated immunoglobulin like receptor 1 (A8MZ84)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEREMEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH
Protein: Morpheyus, isoform A (Morpheyus, isoform B) (Q9V9X1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE59626p
- Putative inorganic phosphate cotransporter
- Mitochondrial import inner membrane translocase subunit Tim22
- FI18310p1
- trypsin
- Peptidase S1 domain-containing protein
Sequence:
MHLRSMTKKRGVSMMALLGLMLLLVDTSVAARKLPKRPAVKPLKTFPRNNATPIPPTGAGSGVATPNGSELPKPLSVEPAEAIAASPPGSIGDSSGASAAAPVPPAAASAAAVAETKADDLDPTPMATPSGSSSVDEDCEPDMIGFELITGYVLSAPSKQLETLPGTLMLTDCLEACQANESCSAVNYETGLCVMFRSTADQLPGSLSRSQYPVFTVYAQKSCFGVRPCSKAWCIDRVQGYRLPERAKASQSVATRRDCIELCLGETEFTCRSANYYAHSGLCELSDMDRITLSDEANIAAYDGADYLENNCAEEPSKLCEFKRVAGRILKTVDSVHQNVQTLDECRDLCLTAPFRCHSYDYNETGELVCRLSHHSRATLTDLSEPYLSIEEAATYEQSACYNVSIDCRSGEMITKIRTSKLFDGKVYAKGAPKSCAVNVNNSLEFDLKMRYNDLECNVRQSAYGRYMNDIVIQHHDMIVTSSDLGLAVSCQYDLTNKTVVNNVDLGVTGEIESTLSEEIIVDSPNVIMKITARDGSDMKRIAEVGDPLALRFEIVDANSPYEIFVRELVAMDGTDSAEITLIDANGCPTDQYIMSAMQKLANNRKVLLSQFDAFKFPSSELVQFRALVTPCIPRCEPVICDNDENGELKSLLSYGRRKRSVLNGTDGVELAIKSERQKRDVSHQAAGDENILLVQSIQITDKFAFNGADAPGGSGSEAGGLDGLAKLQLDLGTKSDTCINGYGFIIAGALFLLLQLTVIAVWDNMQKRALHKR
Protein: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I) (P27115)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P26572}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P26572}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P26572}. Note=Co-localizes with BRI3 at the perinuclear region. {ECO:0000250|UniProtKB:P26572}.
Interaction partners:
- Alpha-mannosidase
- Alpha-mannosidase
- alpha-1,2-Mannosidase
- alpha-1,2-Mannosidase
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Dol-P-Man:Man
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPVPSRLPSDNALDDDPASLTREVIRLAQDAEVELERQRGLLQQIREHHALWSQRWKVPTAAPPAQPHVPVTPPPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQVIASYGSAVTHIRQPDLSNIAVQPDHRKFQGYYKIARHYRWALGQIFHNFNYPAAVVVEDDLEVAPDFFEYFQATYPLLKADPSLWCVSAWNDNGKEQMVDSSKPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRKGRACVRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVPFTQLDLSYLQQEAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFLFRGRRVHLAPPQTWDGYDPSWT
Protein: Mitochondrial import receptor subunit TOM5 (Translocase of outer membrane 5 kDa subunit) (P80967)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.
Subcellular location: Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Outer membrane-anchored. {ECO:0000305}.
Interaction partners:
- Mitochondrial import receptor subunit TOM7
- Mitochondrial import receptor subunit TOM6
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM22
- Sorting assembly machinery 37 kDa subunit
- Mitochondrial import receptor subunit TOM20
- Sorting assembly machinery 50 kDa subunit
- Sorting assembly machinery 35 kDa subunit
- Mitochondrial import receptor subunit TOM70
- Mitochondrial distribution and morphology protein 10
Sequence:
MFGLPQQEVSEEEKRAHQEQTEKTLKQAAYVAAFLWVSPMIWHLVKKQWK
Protein: Cytoglobin-1 (Nitric oxygen dioxygenase CYGB) (EC 1.14.12.-) (Nitrite reductase CYGB) (EC 1.7.-.-) (Pseudoperoxidase CYGB) (EC 1.11.1.-) (Superoxide dismutase CYGB) (EC 1.15.1.1) (Q8UUR3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8WWM9}. Nucleus {ECO:0000250|UniProtKB:Q8WWM9}.
Interaction partners:
- Neuroglobin
- Androglobin
- Myoglobin
Sequence:
MEGDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVRFFTNFPSAKQYFEHFRELQDPAEMQQNAQLKEHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKVDPVYFKILAGVILEVLVEAFPQCFSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK
Protein: Uncharacterized protein Rv1320c (P9WQ29)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- cAMP/cGMP dual specificity phosphodiesterase Rv0805
- Nucleoside diphosphate kinase
- Bifunctional
- Pyruvate kinase
- 3,4-dihydroxy-2-butanone-4-phosphate synthase
- Riboflavin biosynthesis protein RibBA
- GTP 3',8-cyclase 2
- GTP 3',8-cyclase 1
- Uncharacterized protein
- GTP cyclohydrolase 1
Sequence:
MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD
Protein: Monosaccharide-sensing protein 3 (Sugar transporter MSSP3) (Tonoplast monosaccharide transporter 3) (AtTMT3) (Q9SD00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar proton-coupled antiporter which contributes to vacuolar sugar import (e.g. monosaccharides including glucose,sucrose and fructose), particularly during stress responses (e.g. in response to cold).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17158605}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tocopherol O-methyltransferase, chloroplastic
- Peptide chain release factor 1
- Protein STRICTOSIDINE SYNTHASE-LIKE 1
Sequence:
MRSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVSGELALLVEGLGVGKDTSIEEYVIGPDNEENEGGNELPRKDQIKLYGPEDGQSWMAKPVKGQSSLALASRQGSMLPRGGSLMDPLVTLFGSIHENLPSENMNASSRSMLFPNMGSILGMMGRQESQWDPERNNEDSSDQDENLNSPLLSPQTTEPDDYHQRTVGTMHRRQSSLFMANVGETATATSIGGGWQLAWKYNDKVGADGKRVNGGLQRMYIHEETANNNTNNIPFSRRGSLLSFHPEGDGHDQVNGYVQAAALVSQASMMPGGKGETAMLPKEVKDGPGWRELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSLLTNLGISAESASLLISALTTLLMLPCILVSMRSLMLSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVISEFFSVGAKQQDAAASFLSDG
Protein: C2H2-type domain-containing protein (Q3UT31)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHTGEKPYECHQWEKAFSSHSNLLQPKGTHTGEKCYECDLCGKAFSQHYTVQKHKRTHIGQKPYKCNECDKAFSQNRDLQTHKRRHTGEKPYNCNKCEKAFSQHNALQYHRRIHSGEKPYKCNNCEKAFSQHNALKYHRRIHSGEKPYKCNECDKLFRQSSDLQKHRRTHTGEKPYKCNQCEKVFSQHHHLQIHKRSHTGEKPFKCNECDKAFSQLGNLQSHRRIHTGEKPYKCNTCEKAFSQHSHLQSHRRIHTGEKPYRCNKCEKAFSQHSNLQSHRRIHNGEKSFKCNKCEKAFLQHYSLQRHKRIHTG
Protein: Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Ferry endosomal RAB5 effector complex subunit 4) (Fy-4) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog) (O95825)
Organism: Homo sapiens (Human)
Subcellular location: Early endosome {ECO:0000269|PubMed:37267905}.
Interaction partners:
- Protein phosphatase 1 regulatory subunit 21
- Cytosol aminopeptidase
- Glutamine amidotransferase-like class 1 domain-containing protein 1
- Metallothionein-2
- Ferroportin
Sequence:
MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF
Protein: Translocator protein homolog (O94327)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in the transport of porphyrins and heme.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDLNYQVFTSISKNWWSASLVPVACGWFIGNSYKPRKDYENKKQPKFHPPASAFGPAWTLLYLTMGYASHLAYKADPLMITNASRNGSILYIAQLAANFAWMPLFYGLAKPKLALADLGILTGLVGWLAKTWWPLAPTASKWLIPYLAWLGYAGYLNLGYCLLN
Protein: Chitin deacetylase 2 (EC 3.5.1.41) (Q06703)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is a component of the spore wall.
Subcellular location: Prospore {ECO:0000305|PubMed:9133736}.
Interaction partners:
- Sporulation-specific chitinase 2
- Chitin deacetylase 1
- Endochitinase
- Chitin synthase 1
- Chitin synthase 3
- Chitin synthase 2
- Chitin synthase export chaperone
- Uncharacterized protein YGL138C
- Guanine nucleotide-binding protein subunit beta
- Sporulation-specific protein 2
Sequence:
MRIQLNTIDLQCIIALSCLGQFVHAEANREDLKQIDFQFPVLERAATKTPFPDWLSAFTGLKEWPGLDPPYIPLDFIDFSQIPDYKEYDQNHCDSVPRDSCSFDCHHCTEHDDVYTCSKLSQTFDDGPSASTTKLLDRLKHNSTFFNLGVNIVQHPDIYQRMQKEGHLIGSHTWSHVYLPNVSNEKIIAQIEWSIWAMNATGNHTPKWFRPPYGGIDNRVRAITRQFGLQAVLWDHDTFDWSLLLNDSVITEQEILQNVINWNKSGTGLILEHDSTEKTVDLAIKINKLIGDDQSTVSHCVGGIDYIKEFLS
Protein: Cystatin (Q91195)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Cysteine proteinase inhibitor.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MEWKIVVPLFAVAFTVANAGLIGGPMDANMNDQGTRDALQFAVVEHNKKTNDMFVRQVAKVVNAQKQVVSGMKYIFTVQMGRTPCRKGGVEKVCSVHKDPQMAVPYKCTFEVWSRPWMSDIQMVKNQCES
Protein: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1) (O08699)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Solute carrier organic anion transporter family member 2A1
- 3-alpha-hydroxysteroid dehydrogenase
- Prostaglandin E synthase 3
- Prostaglandin E synthase
Sequence:
MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVKCKAALDEQFEPQKTLFIQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINISSIAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILESIEKEENMGQYIEYTDQIKAMMKFYGILDPSAIANGLINLIEDDALNGAIMKITASKGIHFQDYDLFPSFSKAP
Protein: Putative lipoprotein LppC (UPF0098 protein Rv1911c) (P9WFN3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probably involved in bacterial recognition and uptake by its host (human).
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Cell surface {ECO:0000269|PubMed:25041568}. Note=Immunoelectron microscopy indicates this protein is displaced from the cell surface (PubMed:25041568). {ECO:0000269|PubMed:25041568}.
Interaction partners:
- Probable methyltransferase/methylase
- Large ribosomal subunit protein uL16
- Uncharacterized protein
- Possible oxidoreductase FadB5
- Conserved protein
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein bL36
- Large ribosomal subunit protein bL27
Sequence:
MTSTLHRTPLATAGLALVVALGGCGGGGGDSRETPPYVPKATTVDATTPAPAAEPLTIASPMFADGAPIPVQFSCKGANVAPPLTWSSPAGAAELALVVDDPDAVGGLYVHWIVTGIAPGSGSTADGQTPAGGHSVPNSGGRQGYFGPCPPAGTGTHHYRFTLYHLPVALQLPPGATGVQAAQAIAQAASGQARLVGTFEG
Protein: Transcriptional regulator (Q2L4Q4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR001705}.
Interaction partners:
Sequence:
MPLNSSLASKNYDYDYDSIQPYFYVDNEDEDFYHQQPGQLQPPAPSEDIWKKFELLPTPPLSPSRPSLSSIFPSTADQLEMVTEFLGDDVVNQSFICDADYSQTFLKSIIIQDCMWSGFSATAKLEKVVSERLASLQTARKDSAVGDNAECPTRLNANYLQDPNTSASECIDPSVVFPYPITETPKPSKVAPPTDLALDTPPNSGSSSSSGSDSEDDDEEEDDEDEEEIDVVTVEKRQAVKRCDPSTSETRHHSPLVLKRCHVSTHQHNYAAHPSTRHEQPAVKRLRLENSSSRVLKQISSNRKCSSPRTSDTEDYDKRRTHNVLERQRRNELKLSFFALRDEIPDVANNEKAAKVVILKKATECIYSMQTDEQRLVNLKEQLRRKSEHLKQKLAQLQNSCLSSKRH
Protein: Ras-related protein Rab-4A (EC 3.6.5.2) (P56371)
Organism: Mus musculus (Mouse)
Function: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P20338}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20338}. Cytoplasm {ECO:0000250|UniProtKB:P20338}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000250|UniProtKB:P20338}.
Interaction partners:
- Rabenosyn-5
- RUN and FYVE domain-containing protein 1
- Rab GTPase-binding effector protein 1
- Rab11 family-interacting protein 1
- TBC1 domain family, member 16
- A-kinase anchor protein 10, mitochondrial
- GRIP1-associated protein 1
- Kinesin-like protein KIF3A
- Early endosome antigen 1
- Rab5 GDP/GTP exchange factor
Sequence:
MAQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVLILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFMQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRTQAPSAQECGC
Protein: TRAF-type domain-containing protein (D6XEI2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
METESKTTVTSGAPWKYNGALVRDPTKRKSSDLLPKNLRKCPYCRRFGCSEHISRCGQQLVECSCCGMEVEMARLAAHEEYYCKGRERSQTRVLCSEPPTPPCEQKSDVSCSKGHVCEDVLPSATERTAQVCRKHTDRKVKPAVSNGKQAVETNLKGVSPECKIKGDDVQQTATHVYPVEPPPLPNTVQLEERTAVGALTENPSERSKMDGEVVRQKPSFSGFVKASHEVLKDIKNCRSHATHSTKCNTTTSLWGASRRLSGMPYPRLRGSSAFGAFTGFSKVAKGNVGVASRTETRHSRQQKDDTLTETGPSIPPQRVCVRSKSAAAGQ
Protein: Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) (P35625)
Organism: Homo sapiens (Human)
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- 72 kDa type IV collagenase
- Disintegrin and metalloproteinase domain-containing protein 17
- Matrix metalloproteinase-9
- Vascular endothelial growth factor receptor 2
- EGF-containing fibulin-like extracellular matrix protein 1
- Matrix metalloproteinase-14
- Metalloproteinase inhibitor 2
- Matrilysin
- Stromelysin-1
- A disintegrin and metalloproteinase with thrombospondin motifs 5
Sequence:
MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP