wanglab/gogpt-training-data huggingface dataset:
Protein: Canoe, isoform H (A0A0B4KG43)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSHDKKMLDREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQDAGQKVATKCIRVASDATVTDVIDTLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKNIDQKTTPIEQTDLNFKRKLSKREKKEQKKKEKMAKLSSDPPTSNGSHLGLGNGVGASSGSAHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQVNSDGTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGAANGANHISGDREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFGPSIQPRHCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQLDSACLYESRSPTSPGSWNDEDGALSSTHKSDYDHHQQANHSSAYHNNNNNSSDHPLSSTLRDVVDSKAGQDQGANSGNYDGQSLEGNLENETKSISSLKSGGSNSQDRSPKMTGSGILAGGGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDVNVPHFKLAPVYSLYLCARYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQEQYTDPRILAFWMANSSEFLHFLKSDRHISAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENIDHDSAAGLVLTVLGSAMALLRRCRVNAALTIQLFSQLFHYINVICFNTIVANSQMCTGDWGKVMTERLQLLELWAERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALLQQEKLPRNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVDFLNPLQQQGMCRLAAQPTSIGLWTVYMHQFNARSSSAMSNKLPQPELQLIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIYHGLATLLQQPSPVIQRALANSKSRSTHSLHNNTSGMGGIGGAAAGGMLGQPNGSQNNANGNGNGNEQGFYQNLSVYRAQNQSQPILNERPPIAAHAAMNAYNGSSPLAPQQQPQQQQQSPYQQQQQQQHMQANANLPPTRPVSAYYHSQQSAQQQLQQQQQQQQQHSLQQQQFALSSGNLNGQQQQQQQHQHQHQLTLNNRTKSQQNFQHTLRMQQMMAPSMPNISNMYHHQQQQQQQLPLQQQQQQQQQPLMSSSQSMQNVNDFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQQQQQASPNFIALPPKPLGSLQSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQQIAPGMNYVASTLDPPKGSYVASNQGNNRPLHSGSNPWEREEREKDLEMRREHIRQWREQQISELSQIVSRSPMQEEQLKTLILERDFERRAQELQEQEEQDQEQQYDKENVQELFRLAGGGQVSAIQTPITSYRQTEIKLAEMPDSNSLVDSVPPQPPAPTAQPLSSNTQQPKSILKHNRYSEGGVGPSGAPSSPSKSQKSASFADERHLHTEHPISNLAKELNQLTMLDKDNNNETLDAVVPPPPPPERNSSYLIMSQQKLRGSTGNATSSMGLLKTATSNQAAAAVEIKKASLLNTQTNNNNNLSGSLNNNTMHGSPLSAMELNAAYVSATGTGIIGGLGTPPPPPPLMQRDNKRVSFHDEENNFVSGNSQQQQLQQQYIMDNYGMEHQDLDTIREDTSYLQHNLDASMLPSMPATPDAALWNTSVQSTPGVIGAQEVYRDPRTRRLAEKQQQQQQQRAGDAVPEKLSFKEKMKMFALESGEDKTPKDKLKISRAQRDIDAVH
Protein: Protein MTH1 (P35198)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Glucose transport transcription regulator RGT1
- Low glucose sensor SNF3
- Protein STD1
- High glucose sensor RGT2
- Transcriptional activator HAP3
Sequence:
MFVSPPPATSKNQVLQRRPLESTNSNHGFASSLQAIPENTMSGSDNASFQSLPLSMSSSQSTTSSRRENFVNAPPEYTDRARDEIKKRLLASSPSRRSHHSSSMHSASRRSSVAESGSLLSDNASSYQSSIFSAPSTVHTQLTNDSSFSEFPNHKLITRVSLDEALPKTFYDMYSPDILLADPSNILCNGRPKFTKRELLDWDLNDIRSLLIVEKLRPEWGNQLPEVITVGDNMPQFRLQLLPLYSSDETIIATLVHSDLYMEANLDYEFKLTSAKYTVATARKRHEHITGRNEAVMNLSKPEWRNIIENYLLNIAVEAQCRFDFKQRCSEYKKWKLQQSNLKRPDMPPPSIIPRKNSTETKSLLKKALLKNIQLKNPNNNLDELMMRSSAATNQQGKNKVSLSKEEKATIWSQCQAQVYQRLGLDWQPDSVS
Protein: (+)-bornyl diphosphate synthase, chloroplastic (BPPS) (EC 5.5.1.8) ((+)-alpha-pinene synthase) (EC 4.2.3.121) ((+)-camphene synthase) (EC 4.2.3.116) (SBS) (O81192)
Organism: Salvia officinalis (Sage)
Function: Catalyzes the formation of the (+)-camphor precursor (+)-bornyl diphosphate from geranyl diphosphate. The enzyme also produces significant amounts of (+)-alpha-pinene, (+)-camphene, and (+-)-limonene.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MSIISMNVSILSKPLNCLHNLERRPSKALLVPCTAPTARLRASCSSKLQEAHQIRRSGNYQPALWDSNYIQSLNTPYTEERHLDRKAELIVQVRILLKEKMEPVQQLELIHDLKYLGLSDFFQDEIKEILGVIYNEHKCFHNNEVEKMDLYFTALGFRLLRQHGFNISQDVFNCFKNEKGIDFKASLAQDTKGMLQLYEASFLLRKGEDTLELAREFATKCLQKKLDEGGNEIDENLLLWIRHSLDLPLHWRIQSVEARWFIDAYARRPDMNPLIFELAKLNFNIIQATHQQELKDLSRWWSRLCFPEKLPFVRDRLVESFFWAVGMFEPHQHGYQRKMAATIIVLATVIDDIYDVYGTLDELELFTDTFKRWDTESITRLPYYMQLCYWGVHNYISDAAYDILKEHGFFCLQYLRKSVVDLVEAYFHEAKWYHSGYTPSLDEYLNIAKISVASPAIISPTYFTFANASHDTAVIDSLYQYHDILCLAGIILRLPDDLGTSYFELARGDVPKTIQCYMKETNASEEEAVEHVKFLIREAWKDMNTAIAAGYPFPDGMVAGAANIGRVAQFIYLHGDGFGVQHSKTYEHIAGLLFEPYA
Protein: Protein SENSITIVE TO UV 2 (ATR interacting protein) (AtATRIP) (Protein HYDROXYUREA-SENSITIVE 2) (C8KI33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for tolerance to DNA-damaging and cross-linking agents such as UVB irradiation, gamma-radiation, aphidicolin, ionizing radiation and hydroxyurea (HU), cisplatin (CDDP) and mitomycin C (MMC). Involved in cell-cycle G2/M arrest in response to DNA damage. Required for aluminum-dependent gene regulation and root growth inhibition in an ATR-dependent manner by halting cell cycle progression and triggering loss of the quiescent center (QC).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:28556304}. Cytoplasm {ECO:0000269|PubMed:28556304}.
Interaction partners:
- Checkpoint protein
- Cell cycle checkpoint control protein family
- DNA repair endonuclease UVH1
- SUPPRESSOR OF GAMMA RESPONSE 1
- Serine/threonine-protein kinase ATR
- Cell cycle checkpoint protein RAD17
- Nibrin homolog
- Protein ALUMINUM SENSITIVE 3
- Serine/threonine-protein kinase ATM
- Replication protein A 70 kDa DNA-binding subunit E
Sequence:
MSGNDEEFNDEFLLAIDSIETTLKKADMYRPLPPPYLPTFLPAPPPSTKISSSLSHPMQLQSSAGQQRKQIQVPDPFLSYSPPRELSQRVVSGFNDALMDYSNSTVVTAAKPISPTTSNRRCDSEKDLEIDRLKKELERVSKQLLDVEQECSQLKKGKSKETESRNLCADDNRGQCSTVHASKRIDLEPDVATSSVNHRENDSRMALDDKRSFKTTGVQADVANHSDLSKKLLDIWRTSNYQDPRKNLISELLLACSTDLQILFSFMKISTPPQELNKQEAKTSSDRQSSKALESEKVYQLYSAVTKISYGFVNLKTLVEPLLDLCKAETAVLVHRSLRVLHVLLEHICGDEKRFEASWDANWHSLFKLMNQIASKRTEQDVKQEALSIMNIIVMSTDAYTARESFVSKEVFESISLLLRKEGGLHVRKEAIHLFYLLLNCPKLYDTFDSLHEEKNSSDTENDSEGNFFALEAFGKIFEGLADCLTSPRKTSEDLELCRNVIMILALAASSGNSGYELLSSHKLPQDSSFLMLILHLLVAEIDSESTEFHPKAEIFKARTLLMREILILLNRLVSGLSSSATILKELTTSRDMASLTVDAATRLSRKRNLLGKPESSVERMRNTEIMDLARIFKKRVFAFLGDNTI
Protein: Protein NSG1 (INSIG homolog 1) (P38837)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16270032}; Multi-pass membrane protein {ECO:0000269|PubMed:16270032}.
Interaction partners:
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- NPC intracellular sterol transporter 1-related protein 1
- Lanosterol 14-alpha demethylase CYP51
- ERAD-associated E3 ubiquitin-protein ligase ASI1
Sequence:
MGKKKSKNQLNTGGVPNGVHNTKKEAALPPLGNKLGSASFTAINTLTKPALFSFYDDDITKNEGNVYDKALLSNASQLEMVPPSATARHERSLYAKIINTIAAFFILFIAGILFPMISECLFDNDQLAKGDIVSFLKHGIEIKNKIVAEPDMVPDWAVFGTEGVIFGSIVPFIDSFVRYQHQPKTRSSVYKNTLGSFIRCANTLLGLIFGIRKLEWSSSLQAAGAWSLLNIVLWLFFDGTLTVFFPGLVIGALSAFTCSQCFSQLSLALYFIDFYFFGFLMFSKLGRYLFN
Protein: Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (A0A0G2JZM9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKPDETPMFDPSLLKEVDWSQNTAIFSPAISPMHPGEGLVLRPLCTADLNKGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKSSFLLLQPVSSLTTRLKNAVVCQCSATRGCLWLLGVQMIRKGGDFLTKGIYFQLESFLALYFSTVCLPFLVVKSMGSKQLCHLLSAAHF
Protein: Swarming motility protein SwrD (C0H412)
Organism: Bacillus subtilis (strain 168)
Function: Required for swarming motility. Increases flagellar power, probably via the flagellar stator components MotA and MotB.
Interaction partners:
- Flagellar protein FliL
- Flagellar motor switch protein FliM
- Flagellar motor switch phosphatase FliY
- Flagellar M-ring protein
- Flagellar biosynthetic protein FliP
- Flagellar motor switch protein FliG
- Flagellar biosynthetic protein FliZ
- Flagellar biosynthetic protein FlhB
- Flagellum-specific ATP synthase
- Flagellar biosynthetic protein FliR
Sequence:
MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDEEAVLEKIAAFYRKIQIFAMDQGIEEPE
Protein: CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) (O95400)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly nuclear.
Interaction partners:
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Thioredoxin-like protein 4A
- Probable ATP-dependent RNA helicase DDX23
- Pre-mRNA-processing factor 6
- T-cell surface antigen CD2
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Pre-mRNA-processing-splicing factor 8
- U5 small nuclear ribonucleoprotein 40 kDa protein
- Protein AAR2 homolog
- 116 kDa U5 small nuclear ribonucleoprotein component
Sequence:
MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT
Protein: General transcription factor IIH subunit 1 (A0A8I6AJ08)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLVLGQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATESSTSSHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTALEDKPLDEGYGISSVPSTSNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSVDGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAVNQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVTHIEEMLQTAYNKLHSWQSRRLMKKT
Protein: Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) (Ras excision protein) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form] (P28301)
Organism: Mus musculus (Mouse)
Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
Subcellular location: Secreted {ECO:0000269|PubMed:27432961}. Secreted, extracellular space.
Interaction partners:
- Elastin
- Fibulin-5
- Bone morphogenetic protein 1
- Fibronectin
- Collagen alpha-1
- Collagen alpha-1
- Prostaglandin G/H synthase 2
- EGF-containing fibulin-like extracellular matrix protein 2
- Collagen alpha-2
- Fibrillin-1
Sequence:
MRFAWAVLLLGPLQLCPLLRCAPQTPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDPSATARRPDGDAASQPRTPILLLRDNRTASTRARTPSPSGVAAGRPRPAARHWFQAGFSPSGARDGASRRAANRTASPQPPQLSNLRPPSHIDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
Protein: Ras-related protein RABD2b (AtRABD2b) (Ras-related protein Rab1A) (AtRab1A) (Q9FPJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta 1
- Geranylgeranyl transferase type-2 subunit beta 2
- Rab escort protein 1
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Tetratricopeptide repeat
- PRA1 family protein F1
- 2-nitropropane dioxygenase-like protein
- Trafficking protein particle complex subunit
Sequence:
MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDSYISTIGVDFKIRTVEQDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYASENVNKLLVGNKNDLTSQKVVSTETAKAFADELGIPFLETSAKNATNVEEAFMAMTAAIKTRMASQPAGGAKPPTVQIRGQPVNQQSGCCSS
Protein: RNA-binding protein 24 (RNA-binding motif protein 24) (Q5ZMA3)
Organism: Gallus gallus (Chicken)
Function: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating MYOG levels. Binds to a huge amount of mRNAs (By similarity). Involved in embryonic heart development and myogenic differentiation of somitic muscle progenitors.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6GQD3}. Cytoplasm {ECO:0000250|UniProtKB:D3Z4I3}.
Interaction partners:
- RNA binding protein fox-1 homolog 2
- RNA binding protein fox-1 homolog 1
Sequence:
MHTTQKDTTYTKIFVGGLPYHTTDSSLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPAAAAASTTPYIGYTGAAYAQYSAAAAAYEQYPYAASPAAAAGYVAAGGYGYAVQQPITAAAPGTAAAAAAAFGQYQPQQLQTDRMQ
Protein: Zinc finger protein draculin (Q9W747)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKNTTKPCRTEHHNAEGQRDRMEGNKKGETKAKKSVACSHCKKRFSHKAHLQIHMRVHTGEKPYRCDQCGKCFPYKQSLKLHLDIHAKGNPYTCDECGESFKTRLQLRSHMTLHPKYKPYKCDQCEKSYGREDHLQRHMKLHTGEKPHKCEHCGKSFPMRDLLRSHLMVHSEVKPYTCDQCGKGFTLKKSYNEHMNIHTGERPYTCDQCGKGFPYEQSLNLHMRFHREEKPFTCDQCGQSFSQKGAYNIHMKIHTGEKPYTCDQCGMSFRHGYSLKLHMTHHTGEKPFHCDQCDKCYSTALFLKNHIKTHDKAQIYSCLTCGKTFNQLRGLRLHEKRHSLTKPFMCFDCGKCYFTDTELKQHLPVHSNERPYMCSLCFKSFPRMGSLIVHEKTHNGEKPDCRTGSKKSQDE
Protein: Liver carboxylesterase 1 (EC 3.1.1.1) (Acyl-coenzyme A:cholesterol acyltransferase) (Carboxylesterase 1G) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (ES-x) (Q8VCC2)
Organism: Mus musculus (Mouse)
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P23141}. Cytoplasm {ECO:0000250|UniProtKB:P23141}. Lipid droplet {ECO:0000250|UniProtKB:P23141}. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. {ECO:0000250|UniProtKB:P23141}.
Interaction partners:
Sequence:
MWLCALSLISLTACLSLGHPSLPPVVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVIDGASTYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPSVIVSRSHRDAGAPTYMYEYQYRPSFVSDDRPQELLGDHADELFSVWGAPFLKEGASEEEINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGVPAQAAHRLKDKEVDFWTELRAKETAERSSHREHVEL
Protein: Sigma-54-dependent transcriptional response regulator PilR (Q74D24)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Interaction partners:
- histidine kinase
- RNA polymerase sigma-54 factor RpoN
- Type IV pilus inner membrane protein PilC
- Twitching motility pilus retraction protein
- Type IV pilus biogenesis ATPase PilB
Sequence:
MEIHVLVVDDELSMREFLAILLDREGYTVDQAASAEEALACLERKTYDLVISDVKMPGLDGITLLGRIKEMTPDTAVLLMTAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKILARNALEKRDLKRENLRLRQEVQERYSFSGLIGKSKKMREVYSLIEKVAPSTANVLILGESGTGKELVARAIHYNSQRKGKPFVAVNCGAIPETLMESEFFGHKKGAFTGAVGDRAGLFEQAEGGTLFLDEIGEVPLQLQAKLLRAIQEKEFRRVGGTLDQKADVRLVAASNRDLEEQVKEGSFREDLFYRLNVVQVKMPPLRERGDDIPILVEHFYKKYVQPPYSDRIITQGALKLLMSYGFPGNVRELENLVERCSVLGNREISEECLPPQLHAGKRPECGAVTECELPEEGMDLEAYLDGIEKRILLQALERSGGVKKKAAELLKLTFRSFRYRLAKFGMDEE
Protein: F-box protein SKP2 (P42843)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Adenylyl-sulfate kinase
- Suppressor of kinetochore protein 1
Sequence:
MKRLQLFGRSKYFSLVSSAAKEEEEEEEGCADAKSLLHSTSHDIKSRSLRFNDKSSLMCLPTKVLLLILRTLDFNTLVTLCQVNSRFYNLITNEFLFQNVILDSKLSLLKFNALIHSEFHTSNIVTHSGDCSTQSRSQNARFLVRSIEFKNPQSQDSLLKYSKFYNKSGQDSIIAGSYKLDSYDKDVKKLNNIRLNDETPIITSERIKLLDKLESNYFHYTYIELMLDIIDYLPNLTRVILSDVEPNFKIPLWYSVFNDGSRDFFKKIIKGQQSITNEDLRTFQLSKKFVKEYESKYYSLPRLKILEIKANNKRQRTFNRQRHHQKLVLRPSLFCCFGIINELKLENVTIDTESLDTPMEFLPLFLKNEDNELYSLQSPITALTLDSCDVVPGNGILRLFHSYFKMVKHLSLLKINSKFDLLLCSCFPSLSNLTIDCNSKCFTNEQVVGESYYFQQRSLDTEDDFDDCNSMTETLFEAPSDSKIITPPPTSSVVLSLNLNYISRTTGNDVSNNPSPDNNKKPAMLTAAQLQNFQRQRIPEFHSFYHYYRLLWERLPSKNISINVINIPFTNVYPLSPLSFWEHLARTITSVDETDEDVGDENDQETLIGYENNSIRDNIPNANAVPNLSTVMSPESDIHHTYYWNNSVRRCLRDSLIKLKNRTIEYRDLDVEEFLQNVTLENFFNDFQDPENFKDIPNINLWCFLRNLSKFKAVKIRMLRHFSLCTPRTRYDWELLLKPVLRVNVPIEVRDKDGFVLYSYGQK
Protein: Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC 3.1.3.16) (P23635)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.
Interaction partners:
- Protein phosphatase PP2A regulatory subunit A
- Uncharacterized protein C63.05
- Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
- Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Serine/threonine-protein kinase atg1
- Autophagy protein 13
- Autophagy-related protein 101
- Protein phosphatase methylesterase 1
Sequence:
MSVSGKIGEVDRWIEQLSRCEPLSEEDVIQMCDLAKEVLSVESNVQSVRCPVTVCGDIHGQFHDLMELFNIGGPSPDTNYLFMGDYVDRGYHSVETVSLLIAFKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWQYFTDLFDYLPLTALIEDRIFCLHGGLSPSIDTLDHVRILDRVQEVPHEGPICDLLWSDPDDRPGWGISPRGAGYTFGPDIAEAFNHNNGLDLIARAHQLVMEGYNWTTNHNVVTIFSAPNYCYRCGNQAAIMGIDDHINYAFIQYDTAPRKEELHVTRRTPDYFL
Protein: Heterochromatin protein 1e (RT02928p) (Q9VHG0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone-lysine N-methyltransferase Su
- Heterochromatin protein 6
- GEO12050p1
Sequence:
MDSDADGGETVSNFSENSTDFEETEEYIVERILDRRHYMGQLQYLVKWLDYSDEDNTWESAADLDCHSLIDSIESQKSLKRGQELNNQYETKAKRLKIDPCLVVDSPFNHGFTAQEILKGAKNNGEISFLIRFWHLDQPQVVPSGIAYVEIPQMVLKFYENHCNFHDYLNNYIS
Protein: LIM domain-containing protein 1 (Q9UGP4)
Organism: Homo sapiens (Human)
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.
Interaction partners:
- Serine/threonine-protein kinase LATS1
- Serine/threonine-protein kinase LATS2
- Protein salvador homolog 1
- Trinucleotide repeat-containing gene 6A protein
- Eukaryotic translation initiation factor 4E
- Protein argonaute-1
- Probable ATP-dependent RNA helicase DDX6
- Protein argonaute-2
- LIM domain-containing protein ajuba
- Endoribonuclease Dicer
Sequence:
MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQQQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSKLTVDGAAKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDPSCLTHGDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSLSSSRSSEGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKRPSSTALHQHHF
Protein: Protein HEAT-INDUCED TAS1 TARGET 3 (F4KIH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both basal and acquired thermotolerance.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8LFW5}. Nucleus {ECO:0000250|UniProtKB:Q8LFW5}.
Interaction partners:
- AT-hook motif nuclear-localized protein 13
- ARM repeat superfamily protein
- RNA cytidine acetyltransferase 2
- Nucleic acid-binding, OB-fold-like protein
- Putative nucleobase-ascorbate transporter 10
- At5g12410
- Single-stranded DNA-binding protein
- DExH-box ATP-dependent RNA helicase DExH13
- Eukaryotic translation initiation factor 4C
- Pentatricopeptide repeat-containing protein At2g29760, chloroplastic
Sequence:
MDMNQLFMQSIANSRGLCHPDCEKANNEREDYDASQHAAMVAVNLISSARVILKLDAVYTEYSAQYLVDNAGKEDNQGEMDQQSSQLTLQNLLQYMDENVWNKKEDVQGEREQPLTVKDCLECAFK