wanglab/gogpt-training-data huggingface dataset:
Protein: Secreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (ARS(component B)-81/S) (Anti-neoplastic urinary protein) (ANUP) (P55000)
Organism: Homo sapiens (Human)
Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation.
Subcellular location: Secreted {ECO:0000269|PubMed:14506129, ECO:0000269|PubMed:25919322, ECO:0000269|PubMed:26905431}.
Interaction partners:
- Ly-6/neurotoxin-like protein 1
- Secreted Ly-6/uPAR domain-containing protein 2
- Ly6/PLAUR domain-containing protein 6
- Ly6/PLAUR domain-containing protein 1
- Neuronal acetylcholine receptor subunit alpha-9
- Lymphocyte antigen 6H
- Urokinase plasminogen activator surface receptor
- Lymphocyte antigen 6K
- Neuronal acetylcholine receptor subunit alpha-5
- Neuronal acetylcholine receptor subunit beta-4
Sequence:
MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSEL
Protein: Xrn1 N-terminal domain-containing protein (Q57U81)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGIIGLRKFIDSSSCSKLLHIDTQDEDEETLQRPPERNLSRASSTLQDEYQGIEGPVLCSSDTVTPHADHVLVDLNCIVHSSLRKSTVSGDVSAAGAASMTKRDLIQAVLQRLRFLLTRVVVPTVSLTICIDGPAPYAKLGTQRMRRRQVGLLDTSSAQQLSSLAITPGSLLLVELENALAAQFKLRNGKGFLAEYVPVFLHGSTVAGEGEAKIARSLAFLASCGFGRHSEASRRYNPNDTIVVIGNDIDLTLTCIGATQYHNFSVLGPSSMHLIDVSTLLYRWLYSGVLTEKQQLPSCGEFRLTARELASVRVDFVFLFLLNGGDHYAGAGEVAHILWRRYRTVRGASSMKRSLVSEDLCSVDVDMLADVLQSGEYTGDVDTKVGMQLLRATLWSLQTTVSGACPDYRFVPRICTDAGGPHLNHVRAAVAHCHRKRRPISFIARKTFTRCSSSDPKANAQLVDDNEKSRPPLPLTPLETLVALMPTEASLPTSVATALRSSRKFEHIAHVLVSSNDAHAVADAAREAVEAADAYLTASERYLRDFTDPVQINVPQKAKRLSRHEQHRMLATTGTITVEQPMPVVRRVQMPESFRYLGVDYPTYVKDLIFFSPLDLSASGEAAVEEAEISAGADTSCHTTGNPYLGHENSSFITDIKHAIISRDCVAGVSKTPSNMRRVPAHPSLPEATSLKEVWAGKKPANVKQAHRAEGAERNRHDGAMKNGTNHHNEGKTVTGESMEELRRHFLRKKDKAFVKEVKQFLGSDDFDKDWVVRGRKKPETRGKEKLDAKKNNKSGKKNSVVKTKATKRSSTKGNVKKKVKTNKKKRGSKGKQSTPTRGAEISQAPAEGDVPPLKRSREDSQTGGNENTRHDDSKPQSRNKRQRKVQDHQR
Protein: HHIP-like protein 2 (Q6UWX4)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MLRTSTPNLCGGLHCRAPWLSSGILCLCLIFLLGQVGLLQGHPQCLDYGPPFQPPLHLEFCSDYESFGCCDQHKDRRIAARYWDIMEYFDLKRHELCGDYIKDILCQECSPYAAHLYDAENTQTPLRNLPGLCSDYCSAFHSNCHSAISLLTNDRGLQESHGRDGTRFCHLLDLPDKDYCFPNVLRNDYLNRHLGMVAQDPQGCLQLCLSEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKNIVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLDKKKVEKIRISEMKVSRADPNKADLKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGLFGNAQNKSSLLGKVLRIDVNRAGSHGKRYRVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITRQGRGRIFCGDVGQNRFEEVDLILKGGNYGWRAKEGFACYDKKLCHNASLDDVLPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKNKKWKKQDLCLGSTTSCAFPGLISTHSKFIISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDPSRRAPPGKCKYKPVPVRTKSKRIPFRPLAKTVLDLLKEQSEKAARKSSSATLASGPAQGLSEKGSSKKLASPTSSKNTLRGPGTKKKARVGPHVRQGKRRKSLKSHSGRMRPSAEQKRAGRSLP
Protein: Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn) (Q05876)
Organism: Gallus gallus (Chicken)
Function: Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P06241}. Nucleus {ECO:0000250|UniProtKB:P06241}. Cell membrane {ECO:0000250|UniProtKB:P06241}. Perikaryon {ECO:0000250|UniProtKB:Q62844}. Note=Present and active in lipid rafts (By similarity). Palmitoylation is crucial for proper trafficking (By similarity). {ECO:0000250|UniProtKB:P06241}.
Interaction partners:
- Focal adhesion kinase 1
- SH2 domain-containing protein.
- SHC-transforming protein 1
- DAB1, reelin adaptor protein
- Uncharacterized protein.
- Neuropilin-1
- Tyrosine-protein kinase SYK
- Cell division control protein 42 homolog
- Tyrosine-protein phosphatase non-receptor type 11
- Hematopoietic lineage cell-specific protein
Sequence:
MGCVQCKDKEATKLTDERDGSLTQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHATGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFEALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIATNNTPQTVGLAKDAWEVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSRRPIYIVTEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGDNL
Protein: AB hydrolase-1 domain-containing protein (Q57Y49)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L22p/L17e
- Uncharacterized protein
- Uncharacterized protein
- AMP-dependent synthetase/ligase domain-containing protein
- Large ribosomal subunit protein uL4m
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MRLARTLHHVASATTGGGQMLEGLVNDGPEVAHKQHASFTPFSIQPWQARCVGASRRKLLPQMLMYHGARLGPRPLIILDHSTKGEAGVAEAARKYESILSQLSWDYGAVYIPLHAQCTDSSKDLLEQSCQRICAVMDALDVRWTHFLTYSYGALVAVRMASSQEFPHRVGTLMSLDTPLVTRELLRNMEQREDIAKAERDINVPEDGLAFAKQALLSSLEGPLPCPAAEDESLYRDYLFDPNRIFGAGGLVRDESRYVPLKSLLGVRHPVQLIVPSANPLSDAAAHSEVFGHRRPAVVKCCQRHEDLFKESAAKEVAGVLGAWMRRFEPDCFISKRYEQAANEMGQLMLSTAQVSSESAGKGGGEPRKKKEKKKSKA
Protein: DNA repair protein Rad51 homolog (Protein spindle-A) (RecA protein homolog) (Q27297)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:25632158}. Cytoplasm {ECO:0000269|PubMed:25632158}.
Interaction partners:
- Breast cancer type 2 susceptibility protein homolog
- DNA repair and recombination protein RAD54-like
- ATP-binding cassette sub-family D member 3
- Exonuclease 1
- RecQ-like DNA helicase Blm
- Crossover junction endonuclease MUS81
- DNA repair protein RAD51 homolog 3
- Replication protein A 70 kDa DNA-binding subunit
- FI03211p
- ATP-dependent DNA helicase Q4
Sequence:
MEKLTNVQAQQEEEEEEGPLSVTKLIGGSITAKDIKLLQQASLHTVESVANATKKQLMAIPGLGGGKVEQIITEANKLVPLGFLSARTFYQMRADVVQLSTGSKELDKLLGGGIETGSITEIFGEFRCGKTQLCHTLAVTCQLPISQKGGEGKCMYIDTENTFRPERLAAIAQRYKLNESEVLDNVAFTRAHNSDQQTKLIQMAAGMLFESRYALLIVDSAMALYRSDYIGRGELAARQNHLGLFLRMLQRLADEFGVAVVITNQVTASLDGAPGMFDAKKPIGGHIMAHSSTTRLYLRKGKGETRICKIYDSPCLPESEAMFAILPDGIGDARES
Protein: Serine and arginine-rich-splicing factor 4 (Serine/arginine-rich splicing factor 4) (Zgc:55809) (Q802Y1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transformer-2 protein homolog alpha
- Transformer 2 beta homolog.
- Nuclear RNA export factor 1
- SRSF protein kinase 1a.
- Zgc:153681.
- SRSF protein kinase 1b.
- Heterogeneous nuclear ribonucleoprotein D
- Cell division cycle 5-like protein
- Small nuclear ribonucleoprotein Sm D3.
- Zinc finger, CCHC domain-containing 9.
Sequence:
MSRVYVGKLSYRAREKDVERFFKGYGKILEVDLKNGYGFVEFDDPRDADDAVYDLNGKDLCGKRVIVEHTIGQRRDGGNRSGRSNRYGRGGGGGGGDRYGPPTRTDYRLIVENLSSRCSWQDLKDYMRQAGEVTYADTNKGRKNEGVIEFRQYSDMKRALEKLDGTEVNGRKIRLIEDRPGARRRRSYSRSASRSRSRSRRSRRSRSHSRTSSRSGASGSRSRSRSTSKKAKSRSSRMEESSNGARKGGDSGRDNSLSRSPQNKKSKRENKRGRSDSRSRSRSKSRNDRDLSRESGSKSQEASKSGDEGRAGTHRSRAHSRSRSQTPPNADQRRESRSRSRSRSKSRSHSRSQSYSRSRSRSRSRS
Protein: Wings apart-like protein C-terminal domain-containing protein (Q57US6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKRKRCMADVVGYLDSFMACKRTAESPPLSQSSDGEAMQLSLRSDTSNENCSSSSGGSVPGPDTMHIPTVNEARVRLVKRADSPRLRGSVFETEMNFFCREEENIADMCVYLAEVASSSRTPEALMALVLYFMEHEPDMVMQSLKRAGLQSQLLSALCKSSARSVTDNKEGLYIRFVGHLLTLCDDEVLSDASLVKFFLLSSEKRAEEAAATPAGSKHWSQRAHCPTPPKQRRQDDSALKSAVDKFCRGKSDDTATSLALKALLHIIFRYNQATSFPGEANPCLVFAELGGFEVVTPMLNDADCKDVLHLLEVVTLCERLCPSYDAALQELVILLIRLVAREDTKCENDVLTIALRVLVNGTSLVPHALRDSNRRRERSQLAEFSTKRLMSDNTPLNVAAFILCSAVNIVKWEVASRCDEFARCLVNCPDFLSRIAELTLQCYNAEETERNVVSGYYALLLAVLSLIDTPKVQLRVPVITAVAQATKGTETGKAVESKPMKLIVAILQEFLLFQSTAGSLTKSGLVSMSTIIESVVKCNGIEISSDS
Protein: Leucine-rich repeat LGI family member 2 (Leucine-rich glioma-inactivated protein 2) (Q8K4Z0)
Organism: Mus musculus (Mouse)
Function: Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 23
- Disintegrin and metalloproteinase domain-containing protein 22
Sequence:
MALWRGGGALGLLLLSAACLIPPSAQVRRLARCPATCSCTKESIICVGSSWVPRIVPGDISSLSLVNGTFLEIKDRMFSHLPSLQLLLLNSNSFTVIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNEVTSFDYECTTTGPQTDEAKQRGWQLELSLGFCELIFVFQHPLSDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFEIDDETFFIIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEVQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQQFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLSL
Protein: Sodium channel protein para (Protein paralytic) (Sodium channel 1) (DmNav1) (P35500)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular location: Cell membrane {ECO:0000305|PubMed:2550145}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
Interaction partners:
- Uncoordinated 79, isoform C
- Protein tipE
- Ca[2+]-channel protein alpha[[1]] subunit T, isoform F
- RT03134p
- Hyperkinetic, isoform M
Sequence:
MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTADV
Protein: UTP--glucose-1-phosphate uridylyltransferase 2 (EC 2.7.7.9) (UDP-glucose pyrophosphorylase 2) (UDPGP 2) (UGPase 2) (Q54YZ0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a central role as a glucosyl donor in cellular metabolic pathways.
Interaction partners:
- Phosphoglucomutase-1
- Glycogen [starch] synthase
- UDP-glucose 4-epimerase
- Cellulose synthase catalytic subunit A
- Glycogen phosphorylase 1
- Probable phosphoglucomutase-2
- Glycogen phosphorylase 2
- Glycogen debranching enzyme
- Uncharacterized protein
- Alpha,alpha-trehalose-phosphate synthase B
Sequence:
MMKPDLNSPLPQSPQLQAFGSRSSDLATEDLFLKKLEAISQTAPNETVKNEFLNKEIPSINKLFTRFLKNRKKVIDWDKINPPPADMVLNYKDLPAITEQRTSELASKLAVLKLNGGLGTTMGCTGPKSVIEVRSEKTFLDLSVQQIKEMNERYNIKVPLVLMNSFNTHQETGKIIQKYKYSDVKIHSFNQSRFPRILKDNLMPVPDKLFGSDSEWYPPGHGDVFFALQNSGLLETLINEGKEYLFISNVDNLGAVVDFNILEAMDKNKVEYIMEVTNKTRADVKGGTLIQYEGKAKLLEIAQVPSSKVEEFKSIKKFKIFNTNNIWVNLKAMDRILKQNLLDDMDIIINPKVADGKNIIQLEIAAGAAIEFFNNARGVNVPRSRFLPVKSTSDLFIVQSNLYSLEKGVLVMNKNRPFTTVPLVKLGDNFKKVSDYQARIKGIPDILELDQLTVSGDITFGPNMVLKGTVIIVANHGSRIDIPEGSEFENKVVSGNLHCGAL
Protein: Protein TolB (G5EG67)
Organism: Caenorhabditis elegans
Interaction partners:
- RING-type domain-containing protein
- Uncharacterized protein F10E9.1
- Transmembrane protein
- Stress-associated endoplasmic reticulum protein
- Acyl_transf_3 domain-containing protein
- Verprolin
- Protein quiver
- Tectonic domain-containing protein
- CAP-Gly domain-containing linker protein 1 homolog
Sequence:
MLQLIRMLQRLFVLILVVASVLSSEDRDFRIRTNRVWEEEAPEKQFSGRWQDLETNPYDNVVHFDGETHLANVKQLTFGGMNAEGYFSFDNSKLTLQATGYGTDCDQIYELDLNIDPRLQTLRRISTGLGATTCSYFYKEADNNHRLYAGNWWNVKVDNTTDVSKTCPPKQCANPQTDELKHLCNTSYTWDIFADYDIFKVDRYGNFVQRLTDSPGYDAEGVVSPDGTKIAFTSIRSGDLELYIMDIDGKNLIQITNELGYDGGSFFTPDGKRLIFRASRPKNETEIAKYKKLLSYNLVEPIAMELFIVDIDGQNLRKITNLGEANWAPYMLNDNKRIIFSSNYDTAANGFGAFSLYMVNDDGTGLQQITFGQNQFNSFAMQSYDGKKLVWGSSRNGTMYELNLFIADWIDYPSNTTVAPAAPTVTTTTPGTPSTAAPAAPTVTTTTPGTTTSPSAHLSLLSMFSLLLIACLY
Protein: Heptaketide hydrolyase ayg1 (EC 3.7.1.-) (Conidial pigment biosynthesis protein ayg1) (Q4WZB3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Heptaketide hydrolyase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayp1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone. The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN. 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone. Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN. Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin. DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize. DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins. DHN-melanin also plays a crucial role in fungal virulence, including a protective role against the host's immune defenses. DHN-melanin protects also conidia against amoeba predation.
Subcellular location: Endosome {ECO:0000269|PubMed:26972005}.
Interaction partners:
- Scytalone dehydratase arp1
- Conidial pigment polyketide synthase alb1
- Laccase abr2
- Multicopper oxidase abr1
- Hydroxynaphthalene reductase arp2
Sequence:
MPRWILGDKFDTVFPHKGSLKVLWESRWKSACSKSVYPFHDGSIEDFEPIFNHLISKNINDAASDEYTQAFLPTASALEEKAAQALQAGKHEEASNLLCRAAVVYRISRFPYVDITKPSSIKRVAFERQKQAYLKATSLWTQPIREVTVPHTYRTGNDGAHIPIYIRTPAGADQSNPVPIVLIMTGLDGYRSDNSQRTHEILARGWAAVVAEIPGTADCPADPADPASPDRLWDSVLSYLDQRPELNTAKMVVWGLSAGGYYAIRAAHTHRDRLLGAIAHGPGCHYYLDPEWLAKVNDHEYPFEITAAWATKHGYKTVEEFVAGAQKKFSLVETGIVDQPSCRLLLLNGVDDGVVPIEDCLVLFEHGSPKEGRFYKGLPHMGYPNSLPVSYEWLEQVLASPSKTKN
Protein: Uncharacterized membrane protein C17A5.08 (O13770)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Endoplasmic reticulum vesicle protein 25
- Endosomal protein P24B
- Uncharacterized membrane protein C16E9.09c
- Pre-mRNA-processing protein 45
- Ubiquitin carboxyl-terminal hydrolase 15
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein mL38
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS29
Sequence:
MRVITLSGITLFLLASLASAIELTFKLENQEKQCYYLDSFHTGEKTHFTYAVQSGGSFDVDYMIKAPSQKTVALGKKRRQADVFFTLEEKGEYEFCFDNHMSTFTDKIVTMEITMENELSLPALTRDEAKDYKKDSMQSTVLEISTALSEIDRVQNYFKTREHRNYSTVKSTQARIFWFSLAESIMVVALSALQVFIVKTFFKRSGRRGV
Protein: Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) (Q9H3S7)
Organism: Homo sapiens (Human)
Function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
Subcellular location: Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.
Interaction partners:
- Ubiquitin-associated protein 1
- Charged multivesicular body protein 4b
- Signal transducing adapter molecule 2
- Charged multivesicular body protein 4a
- Zinc finger FYVE domain-containing protein 16
- Zinc finger FYVE domain-containing protein 9
- GRB2-related adapter protein 2
- Tumor susceptibility gene 101 protein
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- 6-pyruvoyl tetrahydrobiopterin synthase
Sequence:
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDPLSLLDPLWTLNKT
Protein: Metal tolerance protein 11 (AtMTP11) (O80632)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cation/proton antiporter involved in endogenous manganese tolerance probably through vesicular trafficking and exocytosis.
Subcellular location: Prevacuolar compartment membrane. Golgi apparatus membrane; Multi-pass membrane protein.
Interaction partners:
- Metal tolerance protein 1
- Metal tolerance protein 12
- Metal tolerance protein C2
- Metal tolerance protein A2
- Metal tolerance protein B
- Metal tolerance protein C4
- Metal tolerance protein A1
- Calcium-transporting ATPase 3, endoplasmic reticulum-type
- Metal transporter Nramp3
- Metal transporter Nramp1
Sequence:
MVEPASPDSDEGISLLEFHGNGDRSWQLNFDDFQVSPEHKEKKSPSKLHNCLGCLGPEDNVADYYQQQVEMLEGFTEMDELAERGFVPGMSKEEQDNLAKSETLAIRISNIANMLLFAAKVYASVTSGSLAIIASTLDSLLDLLSGFILWFTAFSMQTPNPYQYPIGKKRMQPLGILVFASVMATLGLQIILESLRTMLSSHKEFNLTKEQESWVVGIMLSVTLVKLLLVLYCRSFTNEIVKAYAQDHFFDVITNIIGLIAVILANYIDYWIDPVGAIILALYTIRTWSMTVLENVNSLVGKSARPEYLQKLTYLCWNHHKAIRHIDTVRAYTFGSHYFVEVDIVLPADMPLQVAHDIGESLQEKLELLEEIERAFVHLDYEYTHKPEHARSHC
Protein: Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) (Q9HB21)
Organism: Homo sapiens (Human)
Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}; Peripheral membrane protein. Nucleus {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000269|PubMed:11802782}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 13
- Age-related maculopathy susceptibility protein 2
- Complement factor H
- Pleckstrin homology domain-containing family A member 2
- Serine protease HTRA1
Sequence:
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV
Protein: T-cell-specific surface glycoprotein CD28 (CD antigen CD28) (P31042)
Organism: Rattus norvegicus (Rat)
Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P10747}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P10747}.
Interaction partners:
- T-lymphocyte activation antigen CD86
- T-lymphocyte activation antigen CD80
- Growth factor receptor-bound protein 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Protein kinase C theta type
- ICOS ligand
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- T-cell surface glycoprotein CD4
- Cytotoxic T-lymphocyte protein 4
Sequence:
MTLRLLFLALSFFSVQVTENKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLDVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWPLVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP