wanglab/gogpt-training-data huggingface dataset:
Protein: Atrial myosin heavy chain (Myosin-6) (Q6YJK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, myofibril {ECO:0000256|ARBA:ARBA00004657}.
Interaction partners:
Sequence:
MGDALMAEFGKAAPFLRKSDKERLEAQTRAFDIKTECFVVDEKVEYVKGQIQNKDGGKVTVKTEDGRTVTVKDGDVHPQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYDADVVAAYRGKKRTEAPPHIFSISDNAYQYMLTDRENQSVLITGESGAGKTVNTKRVIQYFASIAAAGGSTGKKDSSKGTLEDQIIQANPALEAFGNAKTLRNDNSSRFGKFIRIHFGTSGKLSSADIETYLLEKSRVTFQLKSERNYHIFFQILSNEKPELLDMLLITNNPYDYSYISQGEVTVSSINDNEELIATDKAFDVLGFTSEEKMGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKAAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVDQVYYSIGALAKSVYEKMFNWMVVRINQSLDTKQHRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQSCIDLIEKPLGIMSILEEECMFPKASDQTFKAKLYDNHLGKTNIFQKPRAVKGKAEAHFALSHYAGTVDYNIAGWLVKNKDPLNETVVGLYQKSSLKLLSLLFSSYAGSDGGEKSGGKGAKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCLIPNESKIPGIMDNCLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRCRILNASAIPEGQFIENKKSAEKLLGSLDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDQLARILTGIQAFARGLLMRVEYQKLVERRDALMVVQWNLRSFLGVKNWPWMKLFFKIKPLLKSAESEKEMANMKDEFNKLKEALEKSDARRKELEEKMVSLLQEKNDLLLQVQSEQDTLTDAEERCEQLIKSKIQLEAKVKELSERIEDEEEINADLTAKRRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNITEEMASLDENIMKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERSKRKLEGDVKLTQENVMDLENDKQQLEDKLKKKDFEINQLNQRIEDEQMASVQLQKKLKENQARIEELEEELDAERAARAKVEKQRSDISRELEDISERLEEAGGATSAQVELNKKRDAEFQKIRRDLEESTLQHEATTASLRKKHADSVAELGEQIDNLQRVKQKLEKEKVELKLELDDLASNMESIVKAKVNLEKMCRSLEDQMNEHRSKAEEAQRALNDVSTQKAKLLTENGELGRQLEEKECLISQLTRGKTSYAQQLEDLRRQLEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRALSKANTEVATWRARYETDGIQRTEELEDAKKKLVQKLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMLDLERSNAASAALDKKQRSFDKVMAEWKQKYEESQCELEGAQKEARSLSTELFKLKNSYEETLDHLETIKRENKNLQEEISDLTDQVSEGRKSVHELEKLRKQLEQEKTELQSALEEADASVEHEEGKILRAQLEFNQLKADFERKMSEKDEEMEQARRNYQRMIESLQASLEAETRSRNEALRVKKKMEGDLNEMEIQLSQANRQAADAQKQLKMVQSCLKETQLQMDDTLHSNDDLKENITLLERRNNLMQTELEELRGILEQTERVRKLAEQELTDATERMQLLHSQNTGLINQKKKQESDLLQLQNELEELVQENRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQVAMKGGKKQLQKMEARIRELENELDAEQKRGSESVKGVRKFERRIKELTYQTDEDRKNLARLQDLVDKLQLKVKSYKRSAEEAEELANANTAKLRKLQHELEEAEERADIAESQVNKLRAKTRDGAPGKKSQDE
Protein: Protein LDB18 (Low dye-binding protein 18) (Q07887)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
Interaction partners:
- Nuclear migration protein JNM1
- Protein NIP100
- Centractin
- Actin-like protein ARP10
- WD repeat-containing protein PAC11
- Cytoplasmic dynein intermediate light chain DYN3
- Dynein heavy chain, cytoplasmic
- Nuclear distribution protein nudE homolog 1
- Karyogamy protein KAR9
- Nuclear migration protein NUM1
Sequence:
MPGLKLVEALEYRCDRLERLIGAGYSANSDVSVQLDELYNQLHRLYFQGLKYSQDLLQLFNTFMAEDIENVGAPDDICIFASCFDDIYTLYSAFDELNSQYMEFCQISKSSLDQISFKDANIETKQLKKLPELVDNCNIMILRSIAILNRFIDWNIEVNGFFQFQKKRLLNLQKVIYST
Protein: Aldo-keto reductase (EC 1.1.1.2) (Q90W83)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase 7 family member A1
- Dihydropteridine reductase
- Sorbitol dehydrogenase
- Sepiapterin reductase.
- Aldehyde dehydrogenase 9 family member A1
- glycerol kinase
- Dihydrofolate reductase
- Aldose 1-epimerase
- Uncharacterized protein.
Sequence:
MAVPCMELNNKMKMPVLGLGTWQAPPGKVEEVVKHAIDAGYRHIDCAYFYQNEHEIGNAIKQKIKEGAVKREDLFVVTKLWNTFHEKSLVKEGCKRSLTALQLDYVDLYLMHYPMGFKAGEELLPEDDKGMIIPSDTDFLDTWEAMEELVDCGKVKAIGISNFNHEQIERLLNKPGLKYKPVVNQIECHPYLTQEKLIKYCHSKGIAVTAYSPLGSPNRPWAKPGEPMLLEDPKIKEIAARYHKTPAQVLIRFIIQRNLAVIPKSDKQQRIKENMQVFDFELSKKEMDVILSFNRNWRAIPVPQSANHKDYPFNAEY
Protein: Transmembrane protein 18 (A1Z903)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Interaction partners:
- Large ribosomal subunit protein uL15
Sequence:
MHPGQIEVNEINGYWTFLLSIDWKDPWLIGLILAHILTTTTALLSRNSSNFQVFLFLVLLLAVYFTESINEFAANNWSSFSRQQYFDSNGLFISTVFSIPILLNCMLLIGTWLYNSTQLMVTLKTAQLKERARKERQTKADSESIAHKKAE
Protein: Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Q9QZM5)
Organism: Rattus norvegicus (Rat)
Function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17304222}. Cell projection, lamellipodium {ECO:0000269|PubMed:17304222}. Cell projection, filopodium {ECO:0000269|PubMed:17304222}. Cell projection, growth cone {ECO:0000269|PubMed:10995551}. Postsynaptic density {ECO:0000269|PubMed:10995551, ECO:0000269|PubMed:17304222}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17304222}. Note=Localized to protruding lamellipodia and filopodia tips. May shuttle from the postsynaptic densities to the nucleus. {ECO:0000269|PubMed:10995551, ECO:0000269|PubMed:17304222}.
Interaction partners:
- Nck-associated protein 1
- Actin-binding protein WASF1
- NCK associated protein 1 like
- Cytoplasmic FMR1-interacting protein
- Cytoplasmic FMR1-interacting protein
- Protein BRICK1
- Wiskott-Aldrich syndrome protein family member
- Epidermal growth factor receptor kinase substrate 8
- BAR/IMD domain-containing adapter protein 2
- SOS Ras/Rac guanine nucleotide exchange factor 1
Sequence:
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
Protein: F16B3.3 protein (SMAD/FHA domain-containing protein) (Q9M8A0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DEAD-box ATP-dependent RNA helicase 32
- Nucleolar protein
- G-patch domain-containing protein 1
- At4g28200
- Bystin
- rRNA biogenesis protein RRP36
- MIF4G domain-containing protein / MA3 domain-containing protein
- KRR1 small subunit processome component
- Protein NUCLEOLAR FACTOR 1
- Nucleolar-like protein
Sequence:
MVPPLLKLDFTQGPRAGDSLGFKPGSTIRIGRIVRGNEIAIKDAGISTKHLRIVSDSENWIIHDLGSSNGTILNSDTIDSDTPVNLSHGDEIKLGEYTSILVNFGSDVVQAPQEHKLPPRPRRNNKRLAASDPDPDPIESVQEKPKRTRGSSKQEENELPKSTRASRKKNLDDIADKEEELDVEIEKVVKARVGRPRKNAGSAIAKEEEVVEEKKRVGRPRKNASSAITEEEEVVEEKKGNSRARRGKNSEIVQKSIKLEVEDTPKAVEISEVKSRKRVTRSKQIENECFGLEVKDEKRTTRSTRSKTTEIGGESFLELEMVLNQARKSRAKRKKMDEEPSKETRNDDAGEEVLKNCHVEEDKENEAQEGCSGRSDDICDQEDEKECDGSKRVEQVEIELRKKSTVEGLKCTDKEDGETENSQDIERERENENEKEAQEGCSERSDKEYERVGGGAKRVEQVEIELRKKSTVGEDDLNCTVREDGETENLQEIEEECHDEESDCKVEEAGFATLDEEKVGQGWNNKKVERVEVYLEKMKLREWFDAIEVQLPKQTIEETEKMIEPMRSKSMRVHKHIAEQKEKGD
Protein: Fumarase D (EC 4.2.1.2) (P0ACX5)
Organism: Escherichia coli (strain K12)
Function: In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.
Interaction partners:
- Fumarase E
- Fumarate hydratase class I, anaerobic
- Fumarate hydratase class II
- Fumarate hydratase class I, aerobic
- NADP-dependent malic enzyme
- NAD-dependent malic enzyme
- Malate synthase G
- Malate synthase A
- Malate dehydrogenase
- Malate:quinone oxidoreductase
Sequence:
MGNRTKEDELYREMCRVVGKVVLEMRDLGQEPKHIVIAGVLRTALANKRIQRSELEKQAMETVINALVK
Protein: LIM/homeobox protein Lhx8 (LIM homeobox protein 8) (L3) (LIM/homeobox protein Lhx7) (LIM homeobox protein 7) (O35652)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Factor in the germline alpha
- Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
- Homeobox protein MSX-1
- LIM domain-binding protein 1
- Homeobox protein DLX-2
- Homeobox protein GBX-1
- Homeobox protein DLX-1
- Homeobox protein NOBOX
- Homeobox protein Nkx-2.1
Sequence:
MYWKSDQMFVCKLEGKEVPELAVPREKCPGLMSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ
Protein: General negative regulator of transcription subunit (A0A1D8PE87)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR005290}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
Interaction partners:
- CCR4-NOT core ubiquitin-protein ligase subunit
- General negative regulator of transcription subunit 1
- General negative regulator of transcription subunit 3
- CCR4-NOT core subunit
- CCR4-NOT core subunit
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- CCR4-NOT core DEDD family RNase subunit
- ATP-dependent RNA helicase DHH1
- CCR4-NOT core subunit
- Exosome non-catalytic core subunit
Sequence:
MSARKLQQEFDKLNKKISEGLQAFDEIKDKINATESASQREKLENDLKKELKKLQRSRDQLKQWLGDSSIKLDKNVLQENRTKIEHAMDQFKELEKSSKIKQFSNEGLELQSQQKRSRFGDDAKYQEACTYINEVIEQLNGQNEELEQELDSLSGQSKRKGGSSIQSSIDDVKYKIERNNSHISKLEEVLENLDNDKLDPARIDDIKDDLDYYVENNQDEDYVEYDEFYDQLEVDEEDDVEVQGSLAQMAAETEDERRRDEERKREEKEKEKQQQNPPRTSSSVSSSSSSNQNNIGNNTPPATQIKPSVVTVAAIGDQNNNSASSASSTSTPVKKLKPTLAPAPAPPPITSATSYSNAIKAAQTASTSSTSNSSIAHTANDNNNTNKGNRSVSPLASTDNHTHAPAAVSTPVKVLPPGLNHDTSMNSTLRSESSSPLVGHAKVNNNHELQISRSQSPMVSNENKVFSDTISRIVNVAHSRLNDPLPLQSITGLLETSLLNCPDSYDAEKPRQYNPVNVHPSSIDYPQEPMYELNSSHYMKKFDNDTLFFCFYYGDGIDSISKYNAAKELSRRGWVFNTEFSQWFSKDSKNGGKNRSMSVIQREEENGNIIGDNSNGNEELREKIDDNGGIPSNYKYFDYEKTWLTRRRENYQFATENRQIFQ
Protein: CEntrosomal Protein (Q8MXV3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSREMDILLREKLEMQRNSQELEKKYKKAKFASRELAKILENDLCGTPTTSNLKNFESDDEFFEEKSLFEKSRALSRQQIPNDLLEKTRKIDFSEAKNAKNQDLIDKLIDENENLQISLNREQKMTSSLQDDLEKSRRMVIDRDEHIEELKMKLGKAETKASQCESDLTQTSSDLAMERLRCEVLTGELHEIDGIFRNTQSTIQAYADDNDRLEDQCRQAQRTILTLNSKL
Protein: Uncharacterized protein (Q382U2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MADRAAVVFLFAEEKLLFRYPFTNPFTINLDNNTTTTGVVSAAVTNENPCTQADIITSSGTSTNRPQAPSTGGVRCKPRSARRTLSMAAVATASPSTKCKADDADDEAPRLTTSMLSSNSNADLSGCRSGATNSNDRGNGSIKGGGSVTCVGIETAVLLHLLRAGFVACTTIQFAGVTFLIYPFLPGSTKSHQVALTSLRPPRESNADPTDDREVDSQRQADSAQRVKFLAGQRDNENFATPDPARVVLVVAMSRPDCDDGRITNFVQIFMNVLLREELRTRYVTCQLHKMEGYLRTWRTCGDKDESESLKNSAAFSGPNNVTGGNTALHPPSDLEMYERLSERDDLSLCKEITQLVCSIMAATSKGPTNSTGNASPTTTNPPKALLHSSKIDCKSSANTIGLGESRANYGITTGFTIRDLFGLPVELLAGYRATKRCPAFANARLNSNYIVTIEDDSFVERLAKPYGEAVGRRAAQLLPLSAIWAAITTLPPPLRVGTLYRELERTFAGTSQTRHVTKSQQHGSYTYVTNSSTNTSGAAAEEQSHIADCDILVVEAVEFLRACGVLTIDTELTVIFTHCDISPASGAPHVPEDKITRPCRPQPSQLPLRISTVPAAVCSAASIRIIPASAICMMLLEGLRQSASFGFDTHHAGVSCERSAPSTQPDVTSRTPTSISTLNNTSPSPTVPLEIAGSRERDTHSYSVYCSWGDACPICEELAAASYLWSVGGAPVGLVFPFLSAPIVEAANRRARQGVHSFDRDCCSLLTDQAPWFTSMKPLKAGVTLTSTSPHQLYRELVAGYNEVNSRGAAVPEDAKAGSESKDRHGEKGNGKFNALGRKTLFGSGRDCRRKDGAGDFEATVLTPGGTPGDARAWLAANRDAIESRLNAEKHQRWLLRARIERSKERQRGGAGAVSTGKCRDDGNTNTGGRSKRLSPQPHQRYRKREVVTSRSIPNTYLPLAPTAPLNSAKFFTQPQAQMMEESGEASASTFPYLADDGRAVSVEVLMQVVLHHTVALLWGKARMNVDTLLWMLECNLRRLPSFLAGVRRQKAVVASSANGIEQLDETPAPSVGEECTHAPAHPSQQRCGKGCSEGGVEGRQEKEADLQFHQASAVFSELLLLDKLMQCSHLTLEAIPTKLLFHAVVNSFSDVLLIGRGDSG
Protein: Molybdenum-pterin-binding protein MopB (Q08386)
Organism: Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Interaction partners:
Sequence:
MAATKQGGGDDGRCARGVVLERTGARMGAERVALLAAIGRTGSISAAAREVGLSYKAAWDGVQAMNNLLAAPVVTAAPGGKAGGGAVLTPAGEKLIAAYGAIEAGVAKLLSSFEKSLNLDPAEVLRGLSLRTSARNAWACKVWSVAADDVAAQVRMRLGEGQDLTAVITARSAAEMRLAPGSEVLALVKSNFVLLAGAGVPERLSVRNRVRGRVIERIDAPLSSEVTLDLGGGKTITATITRDSAEMLDLHPGVETTALIKSSHVILALP
Protein: Flavin prenyltransferase UbiX (EC 2.5.1.129) (P0AG03)
Organism: Escherichia coli (strain K12)
Function: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN (By similarity). Acts in concert with UbiD to perform the decarboxylation of 4-hydroxy-3-octaprenyl-benzoate, a step in the biosynthesis of coenzyme Q.
Interaction partners:
- 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
- 4-hydroxybenzoate octaprenyltransferase
- 2-octaprenylphenol hydroxylase
- 2-octaprenyl-6-methoxyphenol hydroxylase
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- Ubiquinone biosynthesis O-methyltransferase
- Ubiquinone biosynthesis accessory factor UbiJ
- Amidophosphoribosyltransferase
Sequence:
MKRLIVGISGASGAIYGVRLLQVLRDVTDIETHLVMSQAARQTLSLETDFSLREVQALADVTHDARDIAASISSGSFQTLGMVILPCSIKTLSGIVHSYTDGLLTRAADVVLKERRPLVLCVRETPLHLGHLRLMTQAAEIGAVIMPPVPAFYHRPQSLDDVINQTVNRVLDQFAITLPEDLFARWQGA
Protein: Acetyltransferase CD1211 (EC 2.3.1.-) (GCN5-related N-acetyltransferase) (GNAT) (Q18B70)
Organism: Clostridioides difficile (strain 630) (Peptoclostridium difficile)
Function: Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers L-threonine, L-serine and L-methionine. It can also use O-acetyl-L-serine, L-tryptophan, L-isoleucine, L-valine, L-homoserine, 7-aminocephalosporanic acid, thiamine pyrophosphate and thiamine.
Interaction partners:
- Diamine N-acetyltransferase
Sequence:
MAQNITLQFVEEKDLENLENVKLLFTEYSNSLNIDLCFQDFNNELKTLPGKYKKPSGSLILAFVDENLAGCVALKKLEGKICELKRLYVRNQFRGLKIGKILLEEIIEEAKKFGYTHMRLDTLPSMKSAQGLYEKFGFYDIEPYTYNPIEGARYMELKL
Protein: Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) (Q7Z2W4)
Organism: Homo sapiens (Human)
Function: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q8K3Y6}. Nucleus {ECO:0000250|UniProtKB:Q8K3Y6}. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250|UniProtKB:Q8K3Y6}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21102435}.
Interaction partners:
- Antiviral innate immune response receptor RIG-I
- E3 ubiquitin/ISG15 ligase TRIM25
- Protein KHNYN
- Poly [ADP-ribose] polymerase 1
- Exosome complex component RRP46
- Exosome complex component RRP42
- Poly
- RNA-binding protein FXR1
- Eukaryotic initiation factor 4A-I
- Protein argonaute-2
Sequence:
MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKLNLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYTEDKACVIS
Protein: Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC (O06137)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
- Probable integral membrane cytochrome D ubiquinol oxidase
- Probable integral membrane cytochrome D ubiquinol oxidase
Sequence:
MNRPSAVSRRQRDLLAASGLLGPRLPRILAAVALGVLSLGSALALAGVSAWLITRAWQMPPVLDLSVAVVAVRAFAISRGVLHYCERLATHDTALRAAGRARTLIYHRLAHGPAAAAVGLHSGDLAARVGADVDELANMLVRALVPIAVAAVLAVAATAVVAAVSVPAAVVLAVCLLVAGVVAPWLAGRTAAAQEAIARQHRGMRDTSAMIALEHAPELRVAGALRNVIADSQRRQHAWADALDAAARTGAIAEAMPTAAIGASLLGAVVAGIGMAPTVAPTTLAILMLLPLSAFEATVALPAAAVQLTRSRIAAARLLDLTGSNRVRETESTVSARLPVGTGVLAADVCCGHQEAQSIRVTIDLPPGARLAVTGASGAGKTTLLMTLAGLLPPVHGRVLLDGTNLSDFDEDELRSAVSFFAEDAHIFATTVRDNLLTARGDCPDDELIEALDRVGLCGWLAGLPEGLSTVLIGGAQAVSAGQRRRLLLARAVLSPARIVLLDEPVEHLDAANADLLRDLLAPNSGIMSAMRTVVVATHHLPNDIQCAELSIATDQRCRRRGTNSSDNNTNASAKT
Protein: Proteasome subunit alpha type-2 (Proteasome subunit alpha 2) (Q27488)
Organism: Caenorhabditis elegans
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta
- 26S proteasome regulatory subunit 7
- Proteasome subunit beta
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit beta
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-1
Sequence:
MGDHYGFSLTTFSPSGKLMQIEYALNAVKNGQPSVGLRAKDGVVLATENVGSVLTDDQPKVEQISKHIGCVYSGMGPDFRILVKKARKIAMEYEMMYGEEMPTIQLVTDIAAVMQEYTQSGGVRPFGASLLIAGWDKNPGRPLLFQCDPSGAYFAWKATALGKNDVNAKTFLEKRFSEALELDDGIHTALLTLRESFDVGMNENNVEVAVCNSTGFHRLTKQQVHDHLGTL
Protein: Metabotropic glutamate receptor 3 (mGluR3) (P31422)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Metabotropic glutamate receptor 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor 2
- Glutamate receptor ionotropic, NMDA 2B
- Vasopressin-neurophysin 2-copeptin
- Metabotropic glutamate receptor 7
Sequence:
MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
Protein: Large ribosomal subunit protein bL20c (50S ribosomal protein L20, chloroplastic) (P12139)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS14c
- 50S ribosomal protein L31
- Large ribosomal subunit protein bL33c
- Os01g0220300 protein
- Large ribosomal subunit protein bL27c
- Os02g0259600 protein
- Small ribosomal subunit protein uS2c
- Large ribosomal subunit protein bL36c
- Os03g0612600 protein
- Small ribosomal subunit protein bS16c
Sequence:
MTRVPRGYIARRRRAKMRSFASNFRGAHLRLNRMITQQVRRAFVSSHRDRVRQKRDFRRLWISRINAATRIHKVFDNYSKLIHNLYKKELILNRKILAQVAVLNSNNLYTISNKIKIIN