wanglab/gogpt-training-data huggingface dataset:
Protein: Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3) (Q4FZC9)
Organism: Mus musculus (Mouse)
Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells (By similarity).
Subcellular location: Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum.
Interaction partners:
- Plectin
- Protein KASH5
- SUN domain-containing protein 3
- SUN domain-containing protein 1
- Nesprin-1
- SUN domain-containing protein 2
- Nesprin-4
- Nesprin-2
- Sperm-associated antigen 4 protein
- SUN domain-containing protein 5
Sequence:
MTQQPQEDFERSVEDAQAWMKVIQEQLQVNDNTKGPRAALEARLRETEKICQLESEGMVKVELVLRAAEALLATCQEGQKPEILARLRDIKSQWEETVTYMTHCHSRIEWVWLHWSEYLLAQDEFYRWFQKMVVALEPPVELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAGSLFSRIGDPSVDEDAQKRMKAEYDAVKARAQRRVDLLAQVAQDHEQYREDVNEFQLWLKAVVEKVHSCLGRNCKLATELRLSTLQDIAKDFPRGEESLKRLEEQAVGVIQNTSPLGAEKISGELEEMRGVLEKLRVLWKEEEGRLRGLLQSRGDCEQQIQQLEAELGDFKKSLQRLAQEGLEPTVKTATEDELVAQWRLFSGTRAALASEEPRVDRLQTQLKKLVTFPDLQSLSDSVVATIQEYQSMKGKNTRLHNATRAELWQRFQRPLNDLQLWKALAQRLLDITASLPDLASIHTFLPQIEAALTESSRLKEQLAMLQLKTDLLGSIFGQERAATLLEQVTSSVRDRDLLHNSLLQRKSKLQSLLVQHKDFGVAFDPLNRKLLDLQARIQAEKGLPRDLPGKQVQLLRLQGLQEEGLDLGTQIEAVRPLAHGNSKHQQKVDQISCDQQALQRSLEDLVDRCQQNVREHCTFSHRLSELQLWITMATQTLESHQGDVRLWDAESQEAGLETLLSEIPEKEVQVSLLQALGQLVMKKSSPEGATMVQEELRKLMESWQALRLLEENMLSLMRNQQLQRTEVDTGKKQVFTNNIPKAGFLINPQDPIPRRQHGANPLEGHDLPEDHPQLLRDFEQWLQAENSKLRRIITMRVATAKDLRTREVKLQELEARIPEGQHLFENLLRLRPARDPSNELEDLRYRWMLYKSKLKDSGHLLTESSPGELTAFQKSRRQKRWSPCSLLQKACRVALPLQLLLLLFLLLLFLLPAGEEERSCALANNFARSFALMLRYNGPPPT
Protein: Matrix protein (Phosphoprotein M2) (P16287)
Organism: Rabies virus (strain SAD B19) (RABV)
Function: Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons.
Subcellular location: Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host cytoplasm {ECO:0000269|PubMed:33208464}.
Interaction partners:
Sequence:
MNLLRKIVKNRRDEDTQKSSPASAPLDDDDLWLPPPEYVPLKELTGKKNMRNFCINGRVKVCSPNGYSFRILRHILKSFDEIYSGNHRMIGLVKVVIGLALSGSPVPEGLNWVYKLRRTFIFQWADSRGPLEGEELEYSQEITWDDDTEFVGLQIRVIAKQCHIQGRVWCINMNPRACQLWSDMSLQTQRSEEDKDSSLLLE
Protein: SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) (O95104)
Organism: Homo sapiens (Human)
Function: Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.
Subcellular location: Nucleus {ECO:0000269|PubMed:31104839}.
Interaction partners:
- Probable helicase senataxin
- DNA-directed RNA polymerase II subunit RPB1
- Nuclear cap-binding protein subunit 2
- Pre-mRNA cleavage complex 2 protein Pcf11
- Transcription elongation factor SPT5
Sequence:
MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLSIGNPIPTVVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAPR
Protein: Phototropin-2 (EC 2.7.11.1) (Defective in chloroplast avoidance protein 1) (Non-phototropic hypocotyl 1-like protein 1) (AtKin7) (NPH1-like protein 1) (P93025)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Phosphorylates BLUS1, a kinase involved in stomatal opening. Mediates calcium spiking of extra- and intracellular origins in response to blue light. Involved in hypocotyl phototropism. Contributes to the chloroplast accumulation in low blue light and mediates their translocation (avoidance response) at high fluence. Regulates stomata opening and photomorphogenesis response of leaf tissue. Not involved in hypocotyl elongation inhibition, anthocyanin accumulation or cotyledon opening.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12821778}; Peripheral membrane protein {ECO:0000269|PubMed:12821778}.
Interaction partners:
- Cryptochrome-1
- Phytochrome A
- Cryptochrome-2
- Protein CHUP1, chloroplastic
- Phytochrome B
- Phytochrome E
- E3 ubiquitin-protein ligase COP1
- Cryptochrome DASH, chloroplastic/mitochondrial
- Root phototropism protein 2
- Protein PHYTOCHROME KINASE SUBSTRATE 4
Sequence:
MERPRAPPSPLNDAESLSERRSLEIFNPSSGKETHGSTSSSSKPPLDGNNKGSSSKWMEFQDSAKITERTAEWGLSAVKPDSGDDGISFKLSSEVERSKNMSRRSSEESTSSESGAFPRVSQELKTALSTLQQTFVVSDATQPHCPIVYASSGFFTMTGYSSKEIVGRNCRFLQGPDTDKNEVAKIRDCVKNGKSYCGRLLNYKKDGTPFWNLLTVTPIKDDQGNTIKFIGMQVEVSKYTEGVNDKALRPNGLSKSLIRYDARQKEKALDSITEVVQTIRHRKSQVQESVSNDTMVKPDSSTTPTPGRQTRQSDEASKSFRTPGRVSTPTGSKLKSSNNRHEDLLRMEPEELMLSTEVIGQRDSWDLSDRERDIRQGIDLATTLERIEKNFVISDPRLPDNPIIFASDSFLELTEYSREEILGRNCRFLQGPETDQATVQKIRDAIRDQREITVQLINYTKSGKKFWNLFHLQPMRDQKGELQYFIGVQLDGSDHVEPLQNRLSERTEMQSSKLVKATATNVDEAVRELPDANTRPEDLWAAHSKPVYPLPHNKESTSWKAIKKIQASGETVGLHHFKPIKPLGSGDTGSVHLVELKGTGELYAMKAMEKTMMLNRNKAHRACIEREIISLLDHPFLPTLYASFQTSTHVCLITDFCPGGELFALLDRQPMKILTEDSARFYAAEVVIGLEYLHCLGIVYRDLKPENILLKKDGHIVLADFDLSFMTTCTPQLIIPAAPSKRRRSKSQPLPTFVAEPSTQSNSFVGTEEYIAPEIITGAGHTSAIDWWALGILLYEMLYGRTPFRGKNRQKTFANILHKDLTFPSSIPVSLVGRQLINTLLNRDPSSRLGSKGGANEIKQHAFFRGINWPLIRGMSPPPLDAPLSIIEKDPNAKDIKWEDDGVLVNSTDLDIDLF
Protein: MIF4G domain-containing protein (Q385C8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Regulator of nonsense transcripts 1, putative
- RRM domain-containing protein
- Mago nashi-like protein,putative
- RNA-binding protein, putative
- RNA-binding protein RBP14, putative
- Probable eukaryotic initiation factor 4A
- C3H1-type domain-containing protein
Sequence:
MSSSVLQFLTERMTLRERNRNPQPGRMAFAEKSPSLTSNLKKATALAKRFKDYSAEASEKVILDQLDVVSFAMFTSEAAQGVVQSLCQGTKMKASDAHSFVVVCSEVHQRYESFWPLVQKGVKENAEKVVSMEELKAAIQRMEVGAAPVGPSGGDGNAGAGSLGSTASSNGVASAAPGSSNNTLSTMKAPMEELNHLRLVVKVTCEWWLAGLLDDAKPVLAFLRLLHGVVEKRLSAPLSPSTTAAVLSLSAFIIREVGIEILGGTNAVVSRLFGAEGTVEDTSVQLSDLANYHGLMELTTGISKPKREDIFFVGSAGVRRVFNPTTKTSDVVDEASLQQAVELSAARLRCVRIMPGMYDSTDAEKEQFFALAVATSKVALKSYLWHKTKLEEWWQLLGEQRDTRGNVVKTSTEDMQFRALAEQVERLHVTCDNLLGMLGYATPPPVKLTVLEPRVAKDIVVTSATKKFYAVSAAETLNRFESDEQRIFYEYVPDFLTISDELLKSLLSEKPSWDSLGRQGVLAQSPCAGVTDAREKKAHKRKEEGEGKDTASNSDTRCVGESRSPSYMKVSTTVERRLWLAWLAVPATLFDEYAVVLQLLEELEQCRSADAIDKWCVQYMQEALRPLEHSSGSVALGSVFFTNCRMLLAMEAWYSPWVQQPDMVPYLSRCIAEFSQYFPDMSEFIAGRLDAHWKSLCKADSGISEEKLRDQVEGTVRYICDLTKFGAIAHLAVFSVLRVGMEDLHGRISPYLISSVMKYCGFFLSRNQTTRQPFNKALGKLESALSKTTLYDEGSDLIRASLDFLHVPSAPRRPVAQVERSPLELYVRHLLNDVLSRQKYKFVCEKLVKVPWEDPAKRNGLVATLRDVQHLKWDNIPLLADLLADLGRAGHDSLVLRIVETVAEDLRRDLEVVPRDTEVEAVEMTEEIRYYAEASQLHAEYRSMSLRLLDCVFITHLCRARVLSFRFVSYIVAQLLCYTPHPNGCSPDCSRLRCCVSLLSGSLTFLPWQQRDSRSRSAERLASLHQLMRKMMALLFVHRYTIRALPLDLSQRLDELVSQLDECMRQGSGVGQPKGRDKHRGGEEKERSQDSVSESTAPPPGMRLPKSLQEAEAYAKVVEEEHVLSANVWYDRMCEKMRKSCREDFPHCRISSVQVRAASCSQVESTVAENVEENLMGLSTQDVDHVYDAVSSHGSDAGESYARGEYDVSTQSDGSSDESPDFDSDYSHSSTLSGFSRSDSDMISEENEDDDMDDEDDEEEEYSDDEEEEEEDEDEDEDEDEDEDEDDDNKKIAAAEALRLRIEEANLDAKLRALMSETQRDGIFRAASAATKGAAAERLIKQELTAGIRLHRQQQRSQQPHEESANRQEMKFVVLRRPVRGGGSTNTKPGGTSAGADPHGASANEGVDRNTLTLPRDTEFARSALHLQEQHRRQRDELREVTLRINRMQESERR
Protein: Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase) (P55073)
Organism: Homo sapiens (Human)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Protein delta homolog 1
- Monocarboxylate transporter 8
- Pro-thyrotropin-releasing hormone
- Retrotransposon-like protein 1
- Solute carrier organic anion transporter family member 1C1
Sequence:
MPRQATSRLVVGEGEGSQGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRRV
Protein: CFEM domain-containing protein (G8B966)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MATFTKVSTFLAIIASLQQLTVATPPACLLACVAQVQKSSSQCSGLNDLACICSNEGDDVKSCLDNICPNGDADTAKKAFESSCSGHTDDDSSSSSSSSQESSSTQESSSSSSEAPSSSSEVESSSSEEEQSSSEAAPSGSSTVEAESTSEAAPSSSTQESEPSASETAGNNNGGGAGEEGQESSTSQEQQPSSSTLETSSVAEETTSSSEVPSVSTQTEGSGANKVGLGALVGLVGAALL
Protein: Glutathione S-transferase S1 (EC 2.5.1.18) (GST class-sigma 1) (Glutathione S-transferase 2) (P41043)
Organism: Drosophila melanogaster (Fruit fly)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in the detoxification of metabolites produced during cellular division and morphogenesis.
Interaction partners:
- Cytosolic Prostaglandin E synthase
- FI02878p
- Glutathione S-transferase D1
- Glutathione S transferase D8
- Glutathione S transferase E12, isoform A
- GH16740p
- GH14654p
- Glutathione S-transferase D2
- Glutathione S transferase O1
- Glutathione peroxidase
Sequence:
MADEAQAPPAEGAPPAEGEAPPPAEGAEGAVEGGEAAPPAEPAEPIKHSYTLFYFNVKALAEPLRYLFAYGNQEYEDVRVTRDEWPALKPTMPMGQMPVLEVDGKRVHQSISMARFLAKTVGLCGATPWEDLQIDIVVDTINDFRLKIAVVSYEPEDEIKEKKLVTLNAEVIPFYLEKLEQTVKDNDGHLALGKLTWADVYFAGITDYMNYMVKRDLLEPYPALRGVVDAVNALEPIKAWIEKRPVTEV
Protein: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (EC 2.4.2.53) (Polymyxin resistance protein PmrF) (Undecaprenyl-phosphate Ara4FN transferase) (Ara4FN transferase) (P77757)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase aminotransferase)
- Bifunctional polymyxin resistance protein ArnA
- Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
- Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
- Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
- Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF
- UDP-glucose 6-dehydrogenase
- Phosphoethanolamine transferase EptA
- Sensor protein BasS
- Transcriptional regulatory protein BasR
Sequence:
MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE
Protein: Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) (Q15276)
Organism: Homo sapiens (Human)
Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).
Subcellular location: Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- Ras-related protein Rab-5A
- ADP-ribosylation factor-binding protein GGA1
- ADP-ribosylation factor-binding protein GGA3
- Ras-related protein Rab-4A
- Early endosome antigen 1
- ADP-ribosylation factor-binding protein GGA2
- TRAF3-interacting protein 1
- AP-1 complex subunit gamma-1
- Ras-related protein Rab-8A
Sequence:
MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
Protein: Fructose-2,6-bisphosphatase (FBPase 2) (EC 3.1.3.46) (P32604)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Monofunctional, high-specificity fructose-2,6-bisphosphatase, which releases phosphate from the 2-position of fructose 2,6-bisphosphate. Has no detectable 6-phosphofructo-2-kinase activity.
Interaction partners:
- Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W
- Fructose-1,6-bisphosphatase
- ATP-dependent 6-phosphofructokinase subunit alpha
- ATP-dependent 6-phosphofructokinase subunit beta
- 6-phosphofructo-2-kinase 2
- Glucokinase-1
- 6-phosphofructo-2-kinase 1
- Hexokinase-1
- Putative glucokinase-2
- N-acetylglucosamine kinase
Sequence:
MGYSTISNDNDIKVCVIMVGLPARGKSFISQKIIRYLSWLSIKAKCFNVGNYRRDVSGNVPMDAEFFNFENTDNFKLRELAAQNAIKDIVNFFTKEDGSVAVFDATNSTRKRRKWLKDICEKNNIQPMFLESWSNDHELIINNAKDIGSTSPDYENSEPHVAEADFLERIRQYERFYEPLDPQKDKDMTFIKLVNIIEEVVINKIRTYLESRIVFYVMNIRPKPKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESAGEINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTKIKANIPAVSTYKEKGTSQVGELSQSSTKLHQLLNDSPLEDKF
Protein: F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) (Q9BZK7)
Organism: Homo sapiens (Human)
Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histone deacetylase 3
- F-box-like/WD repeat-containing protein TBL1Y
- F-box-like/WD repeat-containing protein TBL1X
- G protein pathway suppressor 2
- Nuclear receptor corepressor 1
- Catenin beta-1
- Nuclear receptor corepressor 2
- Methyl-CpG-binding protein 2
- S-phase kinase-associated protein 1
- Adenomatous polyposis coli protein
Sequence:
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
Protein: Receptor-associated protein of the synapse (D3ZPG2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWIARKVLDKALDAIEKAQDLAEEVGNKLSQLKLHCLSEGICRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV
Protein: Retinol dehydrogenase 10 (EC 1.1.1.300) (Q80ZF7)
Organism: Rattus norvegicus (Rat)
Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.
Subcellular location: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Retinal dehydrogenase 2
- Cytochrome P450 26A1
- Retinaldehyde dehydrogenase 3
- Aldehyde dehydrogenase 1A1
- Lecithin retinol acyltransferase
- Retinoid isomerohydrolase
- Beta,beta-carotene 15,15'-dioxygenase
- Retinol dehydrogenase 5
- Diacylglycerol O-acyltransferase 1
- All-trans-retinol 13,14-reductase
Sequence:
MNIVVEFFLVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
Protein: Leucine-rich repeat-containing protein 23 (Leucine-rich protein B7) (Q53EV4)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:37804054}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O35125}. Cytoplasm {ECO:0000269|PubMed:31429579}. Note=Within the sperm flagellum, may be associated with the head of radial spoke 3. {ECO:0000305|PubMed:38091523}.
Interaction partners:
Sequence:
MSDEDDLEDSEPDQDDSEKEEDEKETEEGEDYRKEGEEFPEEWLPTPLTEDMMKEGLSLLCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEERAEADVIRQRLKEEKEQEPEPQRDLEPEQSLI
Protein: Multifunctional expression regulator (D0U1P6)
Organism: Wood mouse herpesvirus
Interaction partners:
Sequence:
MAQQMLEAGALDHMMEGLPSDFDFDTSDEEGELSDSPPAEESTGPVRDVVYEPDPMFDDPPPTPSPDIRSPSPKARKRALSPEIIHNSPLLRDTTKYEPATKRSYSYHPRRSPQRENPRQKLKRGTDSRRPNRWNQKNPKQYWSLKPLLDYSKIPRAEYKNAKLLVPTTGKLRPEFYTDRFVDAIIQNAARNCPVSEKAVSLKNIEESFKLLHSFFNSGINKEPWLSTRYFAIFNNGLVVLTHMLDEQMAWAYACLKHGRELPTDDILMSTSEKLSQQLVIKLMEVIKCIEKDGIFSRILKGVADAVCLKAQFLRGMITLKRTPCSLPMYTLFVYVLTIPTLRTRVIRDPLLTQCKDVVLKYQPGDCITLLKAALNCHQCNKDCDKCKYILDPLLGQTHRTKGVFFVCE
Protein: Gamma-aminobutyric acid receptor subunit beta (Ionotropic GABA receptor subunit UNC-49B.2) (G5EFN4)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MARPFTLIVLLSAHLCLHVVVTQDEDSHINTQLLSSVLDRLTNRTTYDKRLRPRYGEKPVDVGITIHVSSISAVSEVDMDFTLDFYMRQTWQDPRLAFGSLDLGLSKEIDSLTVGVDYLDRLWKPDTFFPNEKKSFFHLATTHNSFLRIEGDGTVYTSQRLTVTATCPMDLKLFPMDSQHCKLEIESYGYETKDIDYYWGKKRTDLEITAVKFDTFQLPQFQPTLYFVNTTKAETSSGKYVRLALEVILVRNMGFYTMNIVIPSILIVTISWVSFWLNREASPARVGLGVTTVLTMTTLITTTNNSMPKVSYVKGLDVFLNFCFVMVFASLLEYAIVSYMNKRLVLRREKRRKAAEQQQRNEMPMFNASPKAANNNNPLMEIPENCDCRTIPMMQHPRLVTDGAHTLWPAPFARPKKASKTCCQRWTPAKIDKLSRYGFPLSFSIFNIVYWLYMKYLSLNSSDKIQENDKWQQIH
Protein: Activator of Hsp90 ATPase (O97244)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock protein 90
- Endoplasmin, putative
- Heat shock protein 90, putative
- Heat shock protein 90, putative
- Peptidyl-prolyl cis-trans isomerase
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MSGSVWNSNSWHWEERNYNKWAESYIKYNLSNLKIEKEDLTIYFDNLQVSGNACVSIRKGKQINSFEYIIKFEWLYSKKKEGKDYFGGSVEIPDFSTFSLEENDYAINIERTDESENLRFIYDSILKKEGKEKIKECLKNFQEDLLKHDKNESNKELKIKEEEKIKLENIKTCNEKKTEEENKSNQNINNNINDEKKEGSVWNINNYHWEEKCLTKWAIEELQNIFNKSIIELSNNIFLEFFSCDVEGEASSSLRKKKKILMYDLKITSEWKAYQKNKNQQIEIESKGHVSINDILSDFSSDDNTKYSYYFIFDNKTDEYNQINDVIKLEGPNKINQIIDDFILKMREK
Protein: Hms1p (A0A1D8PMZ4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- Negative regulator of the PHO system
- Importin-95
Sequence:
MIFKLNDYNAFLTSLFDKNNEQLQRHQSHQLQNYNQSQNSNTIMTFANNNNNNNRNNSNINSEIADDENNTNNGNTYHQNGGFPVDFDFGLAPPPFIADLPHNNTNNGNGNSNNSKYYSLPLSETTTTSNRYNNIDYELPSNTEFIAEIGAYVKDSKSNNNDNNRTENLQSKNSSNNTNNSNQRNTTTPTKQNNSNNDNVVVNDIDQFSRFNEFGSNLGDPMILEQDEQMNNSDNPMIFNLNDQMGNNFNNELNRSSQYSNYQQQQQQQQVSQGQIFQDQVSPHSRMSNIPQPISDHQRIKSNNHEYNSNLQSPMSIETAPSTSTTTTNFNKNTAPKTGKKSRNSIKRSSSSSGSSSVLDYQNSKSLTEQASQITFGGITSGSQQGKPINTPITTGTTTTTTATSSSSNSNSMIQGSSPISPLNIHNSPLTTTATTSTSNSAPTKTRGRKIKIEPSSSSSTTSTIINEPTNMINHNPHPGRPRIKSAHNVIEQRYRNKINDKFNALQNSVPTLRILAQKKQREKLLMQQHHNHQQQQRRHSSSTLNGGKNPEYDSSDDEMININKGLIMNNVGGGGNNYNVDQLGILQNSSNQLKQSEEYDDEFDGLMEIEEADQEDQEAGGEEEEEVIDLEGLEPARKLNKGTILAKSIEYIKFLEMKNERMKQEHDELVLKARMLGLVIDEDM
Protein: Protein S100-A5 (Protein S-100D) (S100 calcium-binding protein A5) (P33763)
Organism: Homo sapiens (Human)
Function: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.
Interaction partners:
- Protein S100-A16
- Hornerin
Sequence:
METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKELCLGEMKESSIDDLMKSLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK