wanglab/gogpt-training-data huggingface dataset:
Protein: N-acetylglucosaminidase (Probable surface protein) (Q8XL11)
Organism: Clostridium perfringens (strain 13 / Type A)
Interaction partners:
Sequence:
MNRNRLSCLIVGAVIGAGAIVCTTNTKVHAKPVNEVKNINTSKGNSFGEIISSEDIGLRKGADSSHEIITSIPSGARVNIIDKMSKDWYKVSYKDFTGYLQAKDIRVLGDELNQDNVGLISANQLNVRTSPNENGQVIGTLHKNDKVNVLDKSIDGWYKIDFNGRRAYVSSKYVNLISYKNNEVKTEVKKEPIEGTGKVNINTALNVRQASTTNSRIIGSLKGGEKVNIISESNGFYKIEFNNSYGYVYSKYISKDGDSEKVQVVKQEEVKKEKVDESKKEAKATPKAEPVVLAVRSLNKTGIVNVSSSLNVREGAGTSSKVIGSLSGNTKVTIVGEEGAFYKIEYKGSHGYVAKEYVKDVTESSNSNQGTQTPEKPSTPESTEKTGIVNVSSSLNVREGASTSSKVIGSLSGNTKVIIVGEEGAFYKIEYKGSHGYVAKEYIKDVTESNNSNQGTQTPEKPSTPESTEKTGIVNVSSSLNVREGASTSSKVIGSLSGNTKVTIVGEEGAFYKIEYKGSHGYVAKEYIKDIKDEVVTEPEKPSAPENTEKTGVVNVSSSLNVREGASTSSKVIGSLSGNTKVIIVGEEGAFYKIEYKGSHGYVAKEYIKDVTESNNSNQGTQTPEKPSTPESTEKTGIVNVSSSLNVREGASTSSKVIGSLSGNTKVTIVGEEGAFYKIEYKGSHGYVAKEYVKDVTESNNSNQGTQTPEKPSTPESAEKTGVVNVSSSLNVREGASTSSKVIGSLSGNTKITIVGEEGAFYKIEYKGSHGYVAKEYIKDIKDEVVTEPEKPSTHENSKKTGVVTASKGLNVRKEANTSSQIIGILNSGESVEIIGEENGFYKITYKGQEAYASKNYINIFDGNSNVNPGLDIGNASKTNYGVSLNEYIKLQQRNNPSNYSYSEFEKYINPAKATNKLQFLRIDKFRSVNVSGLSSRLSNKGVLTGQGQAFVNAAKAFNIDPIYLVAQCLHETGNGTSKLAKGVTITEIADESKPIYNGNGQLVGYHMIKLSKPVTVYNLFGIGAKDNSSVFPNRALILGTTYAYNRGWTSIENAIKGAAEFVSLNYVHSSRYSQNTLYKMRYNQNVSNIWHQYATTPWYASSIADIMRSYQDLYLENNFTFDVPVFAG
Protein: Metallothionein-2 (MT-2) (Q7ZSY6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Interaction partners:
- Metallothionein
- Melatonin receptor type 1C
- Melatonin receptor type 1A-like
Sequence:
MDPCECAKTGTCNCGATCKCTNCQCTTCKKSCCSCCPSGCSKCASGCVCKGNSCGSSCCQ
Protein: Photosystem II reaction center protein J (PSII-J) (Q6ENF9)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01305}.
Interaction partners:
- Photosystem II reaction center protein L
- Photosystem II reaction center protein I
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein T
- Photosystem II reaction center protein K
- Photosystem II reaction center protein H
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein Z
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein M
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: F-ATPase protein 6 (Q35294)
Organism: Oryza sativa (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNFDHNHVVIMGLNQRDSIWKLLNDYNVNSLKRRRQAEIDAFFEPFERAQYRFNNWQNGIELLDGAEWRNGDIVIPGGGGPVISSPLDQFFIDPLFGLDMGNFYLSFTNESLSMAVTVVLVPSLFGVVTKKGGGKSVPNAWQSLVELIYDFVLNLVNEQIGGNVKQKFFPLSRALDFACLY
Protein: 2-oxoacid:ferredoxin oxidoreductase subunit beta (OFOR) (EC 1.2.7.11) (A0A0E3KBH3)
Organism: Saccharolobus solfataricus (Sulfolobus solfataricus)
Function: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Interaction partners:
Sequence:
MAGLKVEWNDWCPGCGNFGILSAEQQAIQELGLDPKKVVLVSGIGCSGKIPHFIRLPASGVHTLHGRALTFAIGIKLANPSLEVIVNGGDGDQLGIGVGHFVSAGRRNVDLTVIVHNNGVYGLTKGQASPTLKLGVKTKSLPKPNINSDINPIALAISSGYTFVARGYAYDVKHLKEIIKKAIKHKGLAMIDVLQPCPTYNDIHTKEYYDKRVYKLDEDPSWDPIVKKPEEMDDKMSKAILKSMEWGDRTPIGIFYQNELVSTYEQRIAERSPSYLDNPPAHDVIEFEGKPTTDVEDILKERRVT
Protein: Dehydrogenase/reductase SDR family member 9 (Retinol dehydrogenase 1, like) (Q6PBR3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYLYIAGLVVLFYVYRWFRELGRVSNKSEKFVYITGCDTGFGNLLARHLDTKGFRVIAGCYSEKGEDELKKICSDRLITLHLDVTDNENVKKAAETIKSLVGQKGLWAVVNNAGIAFPTAPNDWLEIEDFTPMINVNLIGVIAVTLSVLPLIKKAKGRVVNVASVFGRISTLGGAYCITKYGVEAFNDALRRQMAPFGVKVLCIEPGFFKTIVTDFNIVESTLHRLWNKLPQEVKDEYGSDYVDKTKLTAKELLEKLADGDLMKVVSCMEHAVAAVHPRTRYSPGWDAKFFWLPLSYMPTFISDALLLKKAVQPKASIL
Protein: Breakpoint cluster region protein (EC 2.7.11.1) (F1LXF1)
Organism: Rattus norvegicus (Rat)
Function: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity).
Subcellular location: Postsynaptic density {ECO:0000250|UniProtKB:Q6PAJ1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q6PAJ1}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PAJ1}. Synapse {ECO:0000269|PubMed:20962234}.
Interaction partners:
- Growth factor receptor-bound protein 2
- Tyrosine-protein kinase
- Crk-like protein
- E3 ubiquitin-protein ligase CBL
- Tyrosine-protein kinase.
- Adapter molecule crk
- Signal transducer and activator of transcription 5A
- SHC-transforming protein 1
- Signal transducer and activator of transcription 5B
- SHC-transforming protein 3
Sequence:
MVDSVGFAEAWRAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQPPDGAAEPRASAPRLPPAPADGADPAPVEESEARPDGEGSPSKGRPATARRPAAAAPADRDDRGPPTSVAALRSNFEKIRKGPAQPGSADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQQSAGQGLGEAPRPHYRGRSSESSCGLDGDYEDAELNPRFLKDNLINANGGNRPPWPPLEYQPYQSIYVGGMMVEGEGKSPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQKRHRQCQVVVSEATIVGVRKTGQIWPSDGDSTFQGEADSSFGTPPGYGCAADQAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSPASGALEPTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGFLHAIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCYEKCYNKMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSVKFTSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV
Protein: Optic atrophy 3 protein (Q9H6K4)
Organism: Homo sapiens (Human)
Function: May play some role in mitochondrial processes.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
Sequence:
MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLPPAQLYHWVEMRTKMRIMGFRGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRHKEEEQRAAWNALRDEVGHLALALEALQAQVQAAPPQGALEELRTELQEVRAQLCNPGRSASHAVPASKK
Protein: Actin-3 (EC 3.6.4.-) (P0CJ47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the reproductive actins.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Actin-interacting protein 1-2
- Tubulin beta-3 chain
- Actin-1
- Actin-related protein 4
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-depolymerizing factor 6
- F-actin-capping protein subunit beta
- Actin-related protein 9
- Chromatin structure-remodeling complex protein SYD
Sequence:
MADGEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDALMKILTERGYSFTTTAEREIVRDIKEKLCYIALDYEQELETAKTSSSVEKNYELPDGQVITIGSERFRCPEVLYQPSMIGMENAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWIAKAEYDESGPSIVHRKCF
Protein: Golgin family A protein (Q9T0H4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Peroxisome biogenesis protein 7
- Peroxisome biogenesis protein 5
Sequence:
MGGSTSKDERNSSKRRIKVKANEQRRRETRRELDEKERVILALKMAETEWRKERKRLREEVKRLRQKMEEKEEGKAKQHEWEWVVEQMCLERAVREEAVERWKQLYFAIKNELDDLIHTTYGEALRQKPQEEVAKAVQELRKEVKARGETIETLKGRINLMEKQQNGKEREIDLLRQSLRILGGSSGKNKALSSTTRNLTVFKTKFIGCK
Protein: LD24308p (Orion, isoform A) (Q9W3M4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRFINWVLPLLLATLVALQQPTLTDALIEDVLDIIHVVKEVTSGVLKAWDIVQSSPLAANIDFPLMREKQKKVLQRLKEVSKQIDNTEDQHAQYVALAIESVTSFMHNNAPIMAKMNDISDTINRISSRYQQMQKYEAYKDKLEMSTLITFAEWTVSPNAHSVHHLMDRLHITLLGNEDRSSNTTSTNLLQQLATAYEVSTDQICNTMQSAQQFIYSLYADIALTELKAYTMMEFSWMMLRVYGKGNYTQEAEIMRSEYEKRTERTLKILKDVMLRADRIVYRCDPTKHVRGVTYDEVTRLLQGYIENEVDLNKEETCRETCDFYQSTRSEGCFKDLYCSRQPKCSGRLYNCRFVDSDMWVCPSPQNSTRRYEFIEYENGRVLGQRGKCTRGTTKVDSWWRYLLWHCSYCFCLCDEEGLKSDRFFNLRDTIADVKRNRVVTGLRFVKQNRIFHLQIQEGELLPRGIVNQSTLEWKPVEKYNVFDRHVKNGVDYHKLSYEKRTIDLDDVDTDDNSFVVTGVRFRVVGTHLNLEAYYSEFDFRTGQLIRPEYNSYWKSNDNTDVSGARREKLRLSNADVSTRTIAHSIPLSRHNQYIDFTNTGLDKDAAQSTVPFMDIQDVVSNPPVPLAGIGIYYKGRNGYGGFLGPKIITYDFMPHVQVPKNRF
Protein: Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) (O15020)
Organism: Homo sapiens (Human)
Function: Probably plays an important role in neuronal membrane skeleton.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Interaction partners:
- Spectrin alpha chain, non-erythrocytic 1
- Actin, cytoplasmic 1
- Excitatory amino acid transporter 4
- Metabotropic glutamate receptor 1
- Ataxin-10
- Spectrin beta chain, non-erythrocytic 5
- Spectrin beta chain, non-erythrocytic 4
- Rho guanine nucleotide exchange factor 11
- Puratrophin-1
- Tau-tubulin kinase 2
Sequence:
MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK
Protein: Wiskott-Aldrich syndrome protein family member (WASP family protein member) (X2J5L4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}.
Interaction partners:
Sequence:
MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIGDRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQCDKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAAGRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGIQLVKIQTVGEADIDLRHSTLDAHHQVVGNIQDVDMGVYDTRPPRPNSIELNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQMYDAGMYQSHALYGQTGQGVMSPEPIYGPGTPSRNKPRPSQPPPAPPSNGSGGGTPTASNANTPTRGRSMSTSRDALPPPPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNTFHSIGMTGNQLNSLSDLPPPPPVPDQHSPKMSPPNAAPPPPPPPPPVEEGMGSGNQHTLRPHQILPKSLANGEMQQPGQQNGVPHIVAPKKMLPPFHDPRNDLMKAIRDGITLRKVEKSEQKEIERNAAPLDVASILARRVAIELSESEDSDSEDDSEGWMEPNETSA
Protein: Uncharacterized protein (Q386Z2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWAQQLSLQKQTTKISPADKDAQALITANVFIEGNRMRVLKSMEQYQAVADSAYWNYGYMGGSMVTTMAICLSLSGRLPLLQRYASWISLAGGYFGGKAALGIHNARNLSHVVNTIDSAIVETRKMDEQYNFKIPDYAREVEALQRRKFELLPTSAEAIEARKNDLNNMPLDEKVDALVEAYEKRRQAVGKE
Protein: Synaptophysin-like 1 (A0A8I6A9F2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
PDQPQPAQGAARLHQDPRCGLQFSFVHECIISLYILADIFKPYHIEFASIFAFATCGGFKGKTEIQVNCLSAPGENKTITATFGYPFRLNQASFHSAPNVNVCKVNWEKHVLIGDYSSSAQFYVTFAVLVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIKVATGHRIVEELDPCKSEVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTSASHGQGGVPPTSGM
Protein: Epididymis luminal protein 74 (V9HWF3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADKVASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHLGPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRLLSWSDNWREILDSKRGAAQRE
Protein: Geranylgeranyl pyrophosphate synthase 11, chloroplastic (GGPP synthase 11) (GGPS11) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase 11) (Dimethylallyltranstransferase 11) (EC 2.5.1.1) (Farnesyl diphosphate synthase 11) (Farnesyltranstransferase 11) (EC 2.5.1.29) (Geranyltranstransferase 11) (EC 2.5.1.10) (Q9LIA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Geranylgeranyl diphosphate reductase, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Phytoene synthase 1, chloroplastic
- Isopentenyl phosphate kinase
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Ent-copalyl diphosphate synthase, chloroplastic
- AAA-ATPase At3g28600
- Heterodimeric geranylgeranyl pyrophosphate synthase small subunit
- Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
Sequence:
MATTLSSSSLFIQFRGRRYNSLSSFNNLQKRTVLSLSCALSSQGGDMIPPEGKSNDRNSAFDFKSYMIRKAESVSAALNVSVPLQEPLTIQEAVRYSLLAGGKRVRPLLCIAACELVGGDEATAMSAACAVEMIHTSSLIHDDLPCMDDADLRRGKPTNHKEFGEDMAVLAGDALLALAFEHMTFVSNGLVAPERMIRAVMELAKAIGTKGLVAGQVTDLCSQGLNPDDVGLERLEFIHLHKTAALLEAAAVLGAIMGGGTEEEIEKLRKYARCIGLLFQVVDDILDVTESTKELGKTAGKDVMAGKLTYPRLIGLERSREVAEKLRREAAEQLLGFDSDKAAPLVALASYIACRHN
Protein: Pogo transposable element with KRAB domain (Q9P215)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MESTAYPLNLSLKEEEEEEEIQSRELEDGPADMQKVRICSEGGWVPALFDEVAIYFSDEEWEVLTEQQKALYREVMRMNYETVLSLEFPFPKPDMITRLEGEEESQNSDEWQLQGGTSAENEESDVKPPDWPNPMNATSQFPQPQHFDSFGLRLPRDITELPEWSEGYPFYMAMGFPGYDLSADDIAGKFQFSRGMRRSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIRCHRYGWMTEDLMQDWLEVVWRRRTGAVPKQRGMLILNGFRGHATDSVKNSMESMNTDMVIIPGGLTSQLQVLDVVVYKPLNDSVRAQYSNWLLAGNLALSPTGNAKKPPLGLFLEWVMVAWNSISSESIVQGFKKCHISSNLEEEDDVLWEIESELPGGGEPPKDCDTESMAESN
Protein: Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) (E9PLI3)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU369120}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369120}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Microsome membrane {ECO:0000256|RuleBase:RU369120}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369120}.
Interaction partners:
Sequence:
MFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDP
Protein: (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) (Q9C0C9)
Organism: Homo sapiens (Human)
Function: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:24703950}. Note=Mainly localizes to the cytoplasm.
Interaction partners:
- Nucleosome assembly protein 1-like 1
- Ubiquitin carboxyl-terminal hydrolase BAP1
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Zinc finger protein 687
- 7SK snRNA methylphosphate capping enzyme
- Polyubiquitin-C
- Ubiquitin-like modifier-activating enzyme 6
- WD repeat-containing protein 26
- Ubiquitin-like modifier-activating enzyme 7
Sequence:
MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPDKKGESKTKSEAESASPEETPDGSASPVEMQDEGAEEPHEAGEQLPPFLLKEGRDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHIGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPLEQPVAPEDKGVVISEEAATAAVQGAVAMAAPMAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIVEEEKMEAVPDVERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPEGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLEKAQALPNGVPKASSSPEPPAVAELSDSGQQEPEDGGPAPGEASQGSDSEGGAQGLASASRDHTDQTSETAPDASVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPECTEDK
Protein: Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] (Q61144)
Organism: Mus musculus (Mouse)
Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Presenilin-1
- Putative gamma-secretase subunit APH-1C
- Gamma-secretase subunit PEN-2
- Nicastrin
- Gamma-secretase subunit APH-1A
- Gamma-secretase subunit APH-1B
- Amyloid-beta precursor protein
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Transmembrane emp24 domain-containing protein 10
- Neurogenic locus notch homolog protein 1
Sequence:
MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKRVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI