wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphoglucomutase, chloroplastic (PGM) (EC 5.4.2.2) (Glucose phosphomutase) (Protein REDUCED GRAVITROPIC 2) (Q9SCY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This enzyme participates in both the breakdown and synthesis of glucose (Probable). Factor that affects seed oil content. Accumulated starch in young embryos may play an important role in providing carbon resources for seed storage lipid biosynthesis in oilseed plants (Probable). Promotes gravitropic responses, negative in shoots but positive in roots, by facilitating starch granules (statoliths) formation in hypocotyls and roots columella.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Alpha-glucan phosphorylase 2, cytosolic
- Glucose-6-phosphate isomerase, cytosolic
- Alpha-glucan phosphorylase 1
- Glucose-6-phosphate isomerase 1, chloroplastic
- Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic
- UTP--glucose-1-phosphate uridylyltransferase 2
- UTP--glucose-1-phosphate uridylyltransferase 1
- Probable glucose-1-phosphate adenylyltransferase large subunit, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 3, chloroplastic
Sequence:
MTSTYTRFDTVFLFSRFAGAKYSPLLPSPSFTLSTSGIHIRTKPNSRFHSIIASSSSSSVVAGTDSIEIKSLPTKPIEGQKTGTSGLRKKVKVFMEDNYLANWIQALFNSLPLEDYKNATLVLGGDGRYFNKEASQIIIKIAAGNGVGQILVGKEGILSTPAVSAVIRKRKANGGFIMSASHNPGGPEYDWGIKFNYSSGQPAPETITDKIYGNTLSISEIKVAEIPDIDLSQVGVTKYGNFSVEVIDPVSDYLELMEDVFDFDLIRGLLSRSDFGFMFDAMHAVTGAYAKPIFVDNLGAKPDSISNGVPLEDFGHGHPDPNLTYAKDLVDVMYRDNGPDFGAASDGDGDRNMVLGNKFFVTPSDSVAIIAANAQEAIPYFRAGPKGLARSMPTSGALDRVAEKLKLPFFEVPTGWKFFGNLMDAGKLSICGEESFGTGSDHIREKDGIWAVLAWLSILAHRNKDTKPGDKLVSVADVVKEYWATYGRNFFSRYDYEECESEGANKMIEYLREILSKSKAGDVYGNYVLQFADDFSYTDPVDGSVASKQGVRFVFTDGSRIIFRLSGTGSAGATVRIYIEQFEPDVSKHDVDAQIALKPLIDLALSVSKLKDFTGREKPTVIT
Protein: Target of rapamycin complex subunit LST8 (Protein GbetaL) (TORC subunit LST8) (mLST8) (G protein beta subunit-like) (Mammalian lethal with SEC13 protein 8) (A0A0A0MR05)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU369068}.
Interaction partners:
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTGEPRPGLPHPWPPALASRASPPRLQLPLCWGRLLGLHLRS
Protein: Lysoplasmalogenase TMEM86B (EC 3.3.2.2) (Transmembrane protein 86B) (B0BNF0)
Organism: Rattus norvegicus (Rat)
Function: Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D8N3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8N661}.
Interaction partners:
- Glycerophosphocholine cholinephosphodiesterase ENPP6
- Phospholipase B1, membrane-associated
- Group XIIB secretory phospholipase A2-like protein
- Lysophospholipase D GDPD1
- Lysophospholipase D GDPD3
- Phospholipase A2
- Lysophosphatidylcholine acyltransferase 4
- Phospholipase A2, membrane associated
- Phospholipase A and acyltransferase 3
- Phospholipase A2
Sequence:
MPCCDPYPWIGLNVGRLSSFPLLKYPQVRRWLAPFIVACSLYFLLWIPEDQPSWVSALVKCQPILCLVLFLWAVAPGGSYTWLLQGALTCSAVGDACLIWPEAFFYGMAVFSVAHLLYLWAFGLSPLQPGLLLCTTLASLTYYSFLLLHLEPNMVLPVAAYGLILNTMLWRGLVLGRSAGWGAVLFIFSDGVLAWDTFVYTLPFARLVTMSTYYAAQLLLTLSALRSPGLKTH
Protein: Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) (Q8TBA6)
Organism: Homo sapiens (Human)
Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:9915833}; Single-pass type IV membrane protein {ECO:0000269|PubMed:9915833}. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 7
- Golgin subfamily B member 1
- Conserved oligomeric Golgi complex subunit 3
- Homeobox protein cut-like 1
- Ras-related protein Rab-1A
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 5
- Golgi SNAP receptor complex member 1
- Inositol polyphosphate 5-phosphatase OCRL
Sequence:
MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKSTYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYTPEMHHDQPYGK
Protein: Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) (Q63691)
Organism: Rattus norvegicus (Rat)
Function: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P08571}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P08571}. Secreted {ECO:0000250|UniProtKB:P08571}. Membrane raft {ECO:0000250|UniProtKB:P08571}. Golgi apparatus {ECO:0000250|UniProtKB:P08571}. Note=Soluble, secreted forms seem to exist. They may arise by cleavage of the GPI anchor. {ECO:0000250|UniProtKB:P08571}.
Interaction partners:
- Toll-like receptor 4
- Toll-like receptor 2
- Transcription factor PU.1
- 60 kDa heat shock protein, mitochondrial
- Toll-like receptor
- CD34 molecule
- Macrosialin
- TLR4 interactor with leucine rich repeats
Sequence:
MKLMLGLLLLPLTLVHASPATPEPCELDQDEESVRCYCNFSDPQPNWSSAFLCAGAEDVEFYGGGRSLEYLLKRVDTEANLGQYTDIIRSLPLKRLTVRSARVPTQILFGTLRVLGYSGLRELTLENLEVTGTALSPLLDATGPDLNTLSLRNVSWATTDTWLAELQQWLKPGLKVLSIAQAHSLNFSCKQVGVFPALATLDLSDNPELGEKGLISALCPHKFPTLQVLALRNAGMETTSGVCSALAAARVPLQALDLSHNSLRDTAGTPSCDWPSQLNSLNLSFTGLEHVPKGLPAKLSVLDLSYNRLDRKPRPEELPEVGSLSLTGNPFLHSESQSEAYNSGVVIATALSPGSAGLSGTLALLLGHRLFV
Protein: Guide RNA associated protein, GAP2 (Q57XL7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RNA editing associated helicase 2
- REH2-associated factor 1
Sequence:
MLRLLRRSIVGSTFNIMVRRQNQGSVSQGALNMRDQQAAAAENVTPERVWALWNEGNLFSLSLAQLQGFLSRCGVRTDPAAKKAAVVRQVEEYLHSKDTTVKGGGQGAASPQQHQQHGQQGGYGRWNQASVMQPETLLDLSQAGFYEGAANMVPKAFQLLVSDTAPDVVVSRVNTTAFPGFPSNTECYTLGASEKDVAIRSRYSKVLQWCCLNMSNLQMDGELYVDFGKLLLKPSVMRKNRRIVSSYTLQQRLQVNHPYTWVPTLPESCLSKIQEQFLQPEGFAPIGKGVQLTYSGTIKRSKDQLHVDLDNKGKVLAVNSAWVNLQTAWCTHAKGPDVRLLLRSRPPIRRQDVELFASTPIIKLADDDVADVLPPEHGQLVYLSEDETRLFERVSDRGVTITVREVKRQPLIILRDEEEDPRVEYSLSAHIPANAAKATDVRAVGLTAFELAGRLAGLVAEDFVREYGCEAKL
Protein: Octamer-binding transcription factor 3 (E2JL35)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGHLASDFAFSPPPGGGDGSAGLEPGWVDPRTWLSFQGPPGGPGIGPGSEVLGISPCPPAYEFCGGMAYCGPXVXLGLVPQVGVETLQPEGQAGARVESNSEGTSSEPCADRPNAVKLEKVEPTPEESQDMKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICR
Protein: UPF0742 protein PB2B2.17c (Q9HDU0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Localizes to cytoplasmic dots and the nuclear envelope.
Interaction partners:
- Pentafunctional AROM polypeptide
Sequence:
MALLKKINTQVNRIMKNSSLVQNICFDRVPLFIPRLSLTVKYCLAVKLLIYLLYCWYIYSEVPSVSSKFRSFTFGCVVVYHNKFFPRFIRTHSINSIRTFSKFQVIILFSIEKVTRSESKNHSYSKTDISDLHQGYNNPPSRFISR
Protein: Aplp1 protein (B1WBV6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGPSSPTTRGQGRRRGPPPLPLLLPLSLLLLRAQLAVGNLAGGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAVGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVVQERMNQSLGLLDQNPHLAQELRPQIQELLHAEHLGPSELEASVPGSSSEDKDAPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPAGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Protein: Secreted thaumatin-like protein calA (CetA-like protein A) (Q5AVR1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Secreted thaumatin-like protein that, with cetA, plays an essential role in early conidial germination with a possible role in cell wall remodeling.
Subcellular location: Secreted {ECO:0000269|PubMed:17703972}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17703972}. Secreted, cell wall {ECO:0000269|PubMed:17703972}. Note=Present in the cell walls of the germinating conidia but not in the germtubes (PubMed:17703972). {ECO:0000269|PubMed:17703972}.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit
Sequence:
MLFNKIISLAATLATASALPFAPAPRSISGGVTLINNLSQDLYLWSVSGTASPMVTLPAGQSYQETWQINPTGGGISIKIGCSEDGSDVLQYEYTKVGDLLFWDMSSIDLSSGSPLVAAGFDVSIDDSSCDTVTCAPGDVNCSESYQYPDDHNTRACSSSAAYTLTLGTAN
Protein: Regulator of microtubule dynamics 2 (C9JUD5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPYSTNKELILGIMVGTAGISLLLLWYHKVRKPGIAMKLPEFLSLGNTFNSITLQDEIHDDQGTTVIFQERQLQILEKLNELLTNMEELKEEIRFLKEAIPKLEEYIQDELGGKITVHKISPQHRARKRRLPTIQSSATSNSSEEAESEGGYITANTDTEEQSFPVPKAFNTRVE
Protein: Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III) (P36941)
Organism: Homo sapiens (Human)
Function: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Lymphotoxin-alpha
- Lymphotoxin-beta
- TNF receptor-associated factor 3
- Tumor necrosis factor ligand superfamily member 14
- TNF receptor-associated factor 5
- TNF receptor-associated factor 2
- Mitogen-activated protein kinase kinase kinase 14
- Tumor necrosis factor receptor superfamily member 13C
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 13B
Sequence:
MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
Protein: Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16) (P08779)
Organism: Homo sapiens (Human)
Function: Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Interaction partners:
- Keratin, type II cytoskeletal 6B
- Keratin, type II cytoskeletal 6A
- Keratin, type I cytoskeletal 17
- Keratin, type I cytoskeletal 14
- Keratin, type II cytoskeletal 5
- Protein S100-A7
- Keratin, type I cytoskeletal 10
- Coiled-coil alpha-helical rod protein 1
Sequence:
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS
Protein: Cell division control protein 45 homolog (PORC-PI-1) (O75419)
Organism: Homo sapiens (Human)
Function: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
- WD repeat and HMG-box DNA-binding protein 1
- DNA replication complex GINS protein PSF3
- DNA replication licensing factor MCM3
- DNA replication complex GINS protein PSF2
- DNA replication licensing factor MCM7
- DNA replication complex GINS protein PSF1
- DNA topoisomerase 2-binding protein 1
- DNA replication licensing factor MCM5
Sequence:
MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLLS
Protein: AT07541p (Q5U0S7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
KRKISKISKIREKKQLEMKVKKTHWAMFAITVGIIIGCMICIAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDRALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYFLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHLTLIRMFLFDEYVEWPQEQQKQPEAQDPDPNLGPDGSPPQDKSQDEAEA
Protein: Crossover junction endodeoxyribonuclease RusA (EC 3.1.21.10) (Holliday junction nuclease RusA) (Holliday junction resolvase) (P0AG74)
Organism: Escherichia coli (strain K12)
Function: Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC.
Interaction partners:
- Putative nuclease YbcO
- Uncharacterized protein YdfU
- Prophage NinE homolog
- Uncharacterized protein YbcN
- Uncharacterized protein YlcH
- Uncharacterized protein YlcG
Sequence:
MNTYSITLPWPPSNNRYYRHNRGRTHVSAEGQAYRDNVARIIKNAMLDIGLAMPVKIRIECHMPDRRRRDLDNLQKAAFDALTKAGFWLDDAQVVDYRVVKMPVTKGGRLELTITEMGNE
Protein: Multiple myeloma tumor-associated protein 2 (hMMTAG2) (Q9BU76)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFGSSRGGVRGGQDQFNWEDVKTDKQRENYLGNSLMAPVGRWQKGRDLTWYAKGRAPCAGPSREEELAAVREAEREALLAALGYKNVKKQPTGLSKEDFAEVCKREGGDPEEKGVDRLLGLGSASGSVGRVAMSREDKEAAKLGLSVFTHHRVESGGPGTSAASARRKPRAEDQTESSCESHRKSKKEKKKKKKRKHKKEKKKKDKEHRRPAEATSSPTSPERPRHHHHDSDSNSPCCKRRKRGHSGDRRSPSRRWHDRGSEA
Protein: Transcription factor SOX-18 (P43680)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:11554755}.
Interaction partners:
- Claudin-5
- Roundabout homolog 4
- Cadherin-5
- COUP transcription factor 2
- Vascular endothelial growth factor receptor 2
- Endomucin
- Vascular endothelial growth factor receptor 3
- Angiopoietin-1 receptor
- Recombining binding protein suppressor of hairless
- Transcription factor SOX-17
Sequence:
MQRSPPGYGAQDDPPSRRDCAWAPGIGAAAEARGLPVTNVSPTSPASPSSLPRSPPRSPESGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEAFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLEPGEASFFPPPLAPEDCALRAFRAPYAPELARDPSFCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPFPNPLSPPPESPSLEGTEQLEPTADLWADVDLTEFDQYLNCSRTRPDATTLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG
Protein: Ectopic P granules protein 2 (Q95XR4)
Organism: Caenorhabditis elegans
Function: Involved in autophagy. Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1. Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May also play a role in the removal of sepa-1 from somatic cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20550938, ECO:0000269|PubMed:24140420, ECO:0000269|PubMed:28806108}. Note=Co-localizes with sepa-1 in cytoplasmic aggregates. {ECO:0000269|PubMed:24140420}.
Interaction partners:
- Protein sepa-1
- Autophagy-related protein 11 C-terminal domain-containing protein
- Ectopic P granules protein 3
- Ectopic P granules protein 4
- Guanyl-specific ribonuclease pgl-3
- Protein lgg-1
- Ectopic P granules protein 5
- ZZ-type domain-containing protein
- SKN-1 Dependent Zygotic transcript
- Protein arginine N-methyltransferase 1
Sequence:
MSANRTVTVFSSSAEDQEPIELAEDSLQNLDKMLAEEKEEHQLLKDEVVLLRKENVEAKTYSTLLEIMLDEAEEKASSAQETTSEENNLKILNRDLVAENLELKEMKEELRKIWLSDSKKFQEALTRISDENTKLQKDCHELESIRQCAQFALDNCNEELEKTQTENEEHESRIETLEREVCEKDIAMKDIVERKDEISLQLELQTKEFTSALNDLMYGREDTLKQIHQMKENWKVKQNEFEVEITKLKSQNDYFDSERLQLTDRIRALLNELSDVRLELGSTRLAMKEKAEVTEAVTSFNKDLRDKLEDEIARLGECLQFRKDEHEQDEAVIAHLEEQLKLGSDKAAAFSSEHSDTIELLRESETELMELRMENYDLKEDFKILKEEKEDVNRTCECLREQLSTTIQERDIEKGQMQSEMDAKMVAVHQQYAKQIDNMKYNHMLAINQELIKGQMALESGKKKHANEILTVRNELEQSNAAHQSLRDQCSLLLSSEDDLRTAHLALESKMTLVSEECIALRVSRANAQKEIGNLTEHHKLEVALLEDAKSGIQQRLHYATIEIEQLKKINEVTQAQFKKETDEKNAEINEFQAAMVSMKQQYNVLGNHCRVLTSQGISDRTTIDKLQETIREHTELAIETKRIHDAEIVQLNDAHKKLVDNLGVEELDEEPKASTESEEKAEWEMVDEE
Protein: Anosmin-1 (Adhesion molecule-like X-linked) (Kallmann syndrome protein) (P23352)
Organism: Homo sapiens (Human)
Function: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8842728}; Peripheral membrane protein {ECO:0000269|PubMed:8842728}. Secreted {ECO:0000269|PubMed:8842728}. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space.
Interaction partners:
- Fibroblast growth factor receptor 1
- Prokineticin receptor 2
- Prokineticin-2
- Fibroblast growth factor 8
- Progonadoliberin-1
- Chromodomain-helicase-DNA-binding protein 7
- Gonadotropin-releasing hormone receptor
- Fibroblast growth factor 2
- Variable charge X-linked protein 3
- Steryl-sulfatase
Sequence:
MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSAHRSHLKHRHPHHYKPSPERY
Protein: Alpha-galactosidase (EC 3.2.1.22) (Melibiase) (P06720)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Melibiose permease
- Evolved beta-galactosidase subunit alpha
- Beta-galactosidase
- Maltodextrin glucosidase
- Aldose 1-epimerase
- Evolved beta-galactosidase subunit beta
- Uncharacterized protein YihR
- Melibiose operon regulatory protein
- Mannosylglycerate hydrolase
Sequence:
MMSAPKITFIGAGSTIFVKNILGDVFHREALKTAHIALMDIDPTRLEESHIVVRKLMDSAGASGKITCHTQQKEALEDADFVVVAFQIGGYEPCTVTDFEVCKRHGLEQTIADTLGPGGIMRALRTIPHLWQICEDMTEVCPDATMLNYVNPMAMNTWAMYARYPHIKQVGLCHSVQGTAEELARDLNIDPATLRYRCAGINHMAFYLELERKTADGSYVNLYPELLAAYEAGQAPKPNIHGNTRCQNIVRYEMFKKLGYFVTESSEHFAEYTPWFIKPGREDLIERYKVPLDEYPKRCVEQLANWHKELEEYKKASRIDIKPSREYASTIMNAIWTGEPSVIYGNVRNDGLIDNLPQGCCVEVACLVDANGIQPTKVGTLPSHLAALMQTNINVQTLLTEAILTENRDRVYHAAMMDPHTAAVLGIDEIYALVDDLIAAHGDWLPGWLHR
Protein: Splicing factor YJU2 (Q57WC0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Pre-mRNA splicing factor, putative
- Pre-mRNA-processing factor 19
- Cell division control protein, putative
- Uncharacterized protein
- Pre-mRNA-splicing factor SYF1
- G10 protein
- MI domain-containing protein
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- Uncharacterized protein
- PRP8 protein homologue
Sequence:
MAKINATYGSGYYLAPDVDYRRLEEQQRLERKRKKVKGEAVSPSERDAIRQTFAMPFNVICLHCNCRIARGAHGYVNRRATDETYMGIRIWELEIRCMFCKGHIYLKTDYETAKLTGGYHCSRNCRRGEGDFYGTNQINEEVKAQRAAEKADEGTVDALERENEVMLQLQERERLVEELVEARAGTEEAQTRDELLQVIRARKQQGALMVGDGIEGEFQPEAKRSAEEEEEMYQRFEAQLRLWGGEGTSSWREQHDQQQRSGAKKGGGGEEEEVTAALIARYAGAEGKYGNVFVDDSEDSNDDDREGKSVPLPSATTTPLTTSPSTSANEKSNLVSVLRKGSALASLLDD