wanglab/gogpt-training-data huggingface dataset:
Protein: Probable lysophospholipase 3 (EC 3.1.1.5) (Phospholipase B) (O13857)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the release of fatty acids from lysophospholipids.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Glycerophosphocholine phosphodiesterase gde1
- Lysophospholipid acyltransferase
- Triacylglycerol lipase ptl3
Sequence:
MLFNCFGILALLQILPALAYPPCREQMSDPYEFGESDLMRPGMHDTPLSLMQKREALAISLSKRDSVGSYAPYNVTCPSDYMLRPASDGISSGEQSFIDKRIPKINTQMRSFISNTGLDVDVNSVINDSDGPRLGLAFSGGGLRAMVHGGGVLNAFDSRNGNGSSLAGILQSAMYIAGLSGGSWLVGSVAVNNFANITYLRDNVWNLEHSVFAPHGDNVVENLAYYDDLDDEIDQKKDAGFDTSLTDLWGRALSRKLVDATQGGPNITFSSIRNQTWFQNADYPYPIIISDSRLEEEKAIPANTSIFEFTPYEFGTWDNGIKAFLPMEYVGTHLKNGVPPDHKCIRNYDNAGFVMGTSATLFNTFLLEWSQEVTSNSTLYDIIHKVFEKLSEDQNDIAPYPNPYQNFTTTNTTVKNPFERFDTIDLVDGGEDDENIPIWPLLHPQRFVDVIFAVDATYDDSNGWPDGSSIVTTYERIITYNANKSVDVRGFPYIPDEDTIISLGLNTHPTFFGCDGRNTTAGNHTVDNNTPPLLVYFPNYPWVYYSNISTFTMSMNDTLSSGILENAALSATQNNSDSFAVCLACAMIQRSLERKNMSTPSQCSSCFEQYCWNGTTVNNPSAVSNYAPTVLSASTTSGTSSVRAKPIVFYLFASLLTVSLLL
Protein: CCR4-NOT transcription complex subunit 2 (F8VUB4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF
Protein: Non-homologous end-joining factor xrc4 (Q92361)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:24847916}.
Interaction partners:
- DNA ligase 4
- Uncharacterized protein C23G7.14
- Xrcc4-like factor 1
- Large ribosomal subunit protein P2B
Sequence:
MKFFLSLKDFKGEKFVLRSELDESSAFLCAISPTCRYVLRDEIPWKRLQRNVTSESLTDELIVDLLCGRSESKHTLQLVVLENLCRIYINYVDPFPLRIAWFELEQQALKDHEHFDVLWECSHSIKDLALASMAQQKNELQKLMAYTEQLQEECKSRERKLIMKFADMIKNARNNEDNEDNHHINYEDESDVGTDEQKQQEGVNSSAVSDTDESAVSDEFMQIKEEFPMKALSASPTADASPESAGEDDSHRRSSHESSETVSE
Protein: Actin-related protein 4 (Q84M92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure.
Subcellular location: Nucleus {ECO:0000269|PubMed:12609034, ECO:0000269|PubMed:15063870, ECO:0000269|PubMed:15743449}. Cytoplasm {ECO:0000269|PubMed:12609034}. Note=Localized in the nucleus during the interphase, but is released into the cytoplasm during the mitotic phase (PubMed:12609034).
Interaction partners:
- Protein EIN6 ENHANCER
- RuvB-like helicase
- RuvB-like protein 1
- SWR1-complex protein 4
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Actin-related protein 9
- Actin-related protein 5
- SWR1 complex subunit 2
- SWR1 complex subunit 6
- Phosphotransferases/inositol or phosphatidylinositol kinase
Sequence:
MYGGDEVSAIVVDLGSHTCKAGYAGEDAPKAVFPSVIGAVDGVEAMDVDVDSTKTNSNSEDSKTESEKEKSKRKLYVGSQAMSYRRDHMEVLSPIKDGIVSDWDLVDNIWEHAFKSCLMIDPTEHPMLLAEPPLNTQQQREKAAELMFEKYKVPALFMAKNPVLTSFATGRATSLVVDCGGGSTTISPVHDGYVLQKAVVSSPLGGEFLTDCLLKSLESKGIKIRPRYSFKRKEVRAGEFQVEDVDIPDTTESYKLFCQRMIVGDIKDSICRVPDTPYDDKSYSNIPTTSYELPDGQTLEIGADRFKVPDVMFNPSIVQTIPGMEKYAEMIPSVRGLPHMVMESINKCDVDIRRELYSSILLAGGTSSMQQLKERLEKDLIEESPHSARVKVLASGNTTERRFSVWIGGSILASLGSFQQMWFSKSEYEEHGASYIQRKCP
Protein: Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (Q9ERL9)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Guanylate cyclase soluble subunit beta-1
- cGMP-dependent protein kinase 1
- cGMP-dependent protein kinase 2
- Nitric oxide synthase 1
- guanylate cyclase
- Inosine triphosphate pyrophosphatase
- Bis
- cGMP-specific 3',5'-cyclic phosphodiesterase
- Guanylate cyclase soluble subunit alpha-2
- GTP cyclohydrolase 1
Sequence:
MFCRKFKDLKITGECPFSLLAPGQVPKEPTEEVAGGSEGCQATLPICQYFPEKNAEGSLPQRKTSRNRVYLHTLAESICKLIFPECERLNLALQRTLAKHKIEENRKSSEKEDLEKIIAEEAIAAGAPVEALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSDCTEFVNQPYLLYSVHVKSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYHHQGPNSKPWFQDKDVEDGNANFLGKASGID
Protein: Citrate synthase (A0A1D8PSH3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Aconitate hydratase, mitochondrial
- Malate dehydrogenase
- Malate synthase
- Acetyl-coenzyme A synthetase
- Malate dehydrogenase, cytoplasmic
- Succinate--CoA ligase subunit beta, mitochondrial
- Acetyl-coenzyme A synthetase 2
- Pyruvate carboxylase
- 2-oxoglutarate dehydrogenase, mitochondrial
- Aconitate hydratase, mitochondrial
Sequence:
MSAFRSIQRSTNVAKSTFKNSIRTYASAEPTLKQRLEEILPAKAEEVKQFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPIEGIRFRGRTIPDIQKELPKAPGGEEPLPEALFWLLLTGEVPTDAQTKALSEEFAARSALPKHVEELIDRSPSHLHPMAQFSIAVTALESESQFAQAYAKGANKSEYWKYTYEDSIDLLAKLPTIAAKIYRNVFHDGKLPAAIDSKLDYGANLASLLGFGDNKEFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPFLSLAAGLNGLAGPLHGRANQEVLEWLFKLREELNGDYSKEAIEKYLWETLNSGRVVPGYGHAVLRKTDPRYTAQREFALKHMPDYELFKLVSNIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEQSFYTVLFGVSRAFGVLPQLILDRGIGMPIERPKSFSTEKYIELVKNINKA
Protein: GM26972p (Q8MSE5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKTTKRRRGRPRMPLEIVDIVVTNDSKASAGESVGCDEFDQPVEISNEPDATDSDVNLEEIDLPVEDGLESDHDLPNVQIHKCDTCGIIKNNKSSLVRHQFEHNGIRPYPCKECPKTFLVASELKAHNLTHHTLAPPFACRYCDRRYFSVVGRKKHERVHTNERPFVCDQCGKAFTRTCILKAHMAVHQVVRKYSCDVCDRSFSLKKHLATHFISNTHKRNAEAVTSSSEYMSMLSFESDETWSQGTPLTTSIDEDLVQSQFDLLCQEV
Protein: GATAe, isoform B (GATAe, isoform C) (A0A0B4JDD2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEQQTTQQQQQQQQQQQQQQQLQQQQHQALTKQQLQLLDKIKLESSNGADQLAQQTANNLDEQQEQQQQHQQQAATSVGVVVQTGQAGVSEPEEQYVVVPRNQRRILTTAGTLELNEAREGEPSTNASNASSGSASDSHIEYQRSAHQSPGATHYVQMAPRNAEVTEQVGAAAGAPPGTIFAYPIICNGDDVAAIKIETLEKGEATGESQQQQQQLQQHQHQQQQQCPTPNGASYGETIVISSEAEALQHHHQQQQQHQQQQHQQQHHQHQAAAAASAAAQTVHIATSSHGGTVRFVTEDVRFTTAGPETSASNMYYDVPVVDGSVHANESKTYADLGNAYAPFPPSSSFSSNSYAATLQQGNTIYSVPGTGQFLAKSESGLNQTGLLRQTGPATFQTISFEGGNGIEPLWASPAPPEYQSVQFSNFHPQVIDEYGSGNMSTSHWPPASSIGQYDGSLVTASSTSSPNHELKCENCHGPFLRKGSEYFCPNCPAFMRMAPRITQRQAKPKAAAAPNNRRNGVTCANCQTNSTTLWRRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPKNNGGAPMHRAPLPSMSQGVNLMANSPLYPSQVPVSMLNSQLNSQQNSSPELHDMSTTGQAGGQRVVSISLNATAPPTPDGTLNMSARHHVTGESHSPYSQQSTPQSQSPHLPGTVPINRQIVQPVPTIESSRSSNTELTPSVITRTGLPERSSNN
Protein: Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial (AtGPX1) (PHGPx) (EC 1.11.1.12) (O48646)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Glutathione reductase, chloroplastic
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase DHAR2
- Glutathione synthetase, chloroplastic
- L-ascorbate peroxidase 3
- Monodehydroascorbate reductase 3
- Glutathione S-transferase F6
- Glutathione S-transferase F9
- Glutathione S-transferase U19
- Glutathione S-transferase T1
Sequence:
MLRSSIRLLYIRRTSPLLRSLSSSSSSSSSKRFDSAKPLFNSHRIISLPISTTGAKLSRSEHSMAASSEPKSLYDFTVKDAKGNDVDLSIYKGKVLLIVNVASQCGLTNSNYTELAQLYEKYKGHGFEILAFPCNQFGNQEPGTNEEIVQFACTRFKAEYPIFDKVDVNGDKAAPVYKFLKSSKGGLFGDGIKWNFAKFLVDKDGNVVDRFAPTTSPLSIEKDVKKLLGVTA
Protein: V-type proton ATPase subunit F (Q4GYJ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vacuolar proton pump subunit B
- V-type proton ATPase subunit C
- V-type proton ATPase subunit H
- H
- Uncharacterized protein
- ATP synthase, putative
- V-type ATPase, C subunit, putative
- 
- Vacuolar ATP synthase subunit D, putative
- V-type proton ATPase subunit
Sequence:
MATGRLKNGEERIVGIIGDEDTVTGFLLAGIGDNRPVEAQATGDRKAVAQPNYAVITPSTPLADIEDAFTNMTANPSIGVIIICQHIANEIRHLMEGFTDHIPCILEIPSKGGVYDASKDQVLVKINRALGCQ
Protein: NAD(P)H-quinone oxidoreductase subunit H, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit H) (NADH-plastoquinone oxidoreductase 49 kDa subunit) (NADH-plastoquinone oxidoreductase subunit H) (P0C337)
Organism: Oryza sativa subsp. japonica (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01358}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01358}; Stromal side {ECO:0000255|HAMAP-Rule:MF_01358}.
Interaction partners:
- NAD
- NAD
- NAD
- NAD
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, putative, expressed
- NAD
- NAD
- NADH dehydrogenase iron-sulfur protein 6
- Os07g0640100 protein
Sequence:
MSLPLTRKDLMIVNMGPQHPSMHGVLRLIVTLDGEDVIDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNAPEFLENIQIPQRASYIRVIMLELSRIASHLLWLGPFMADLGAQTPFFYIFRERELIYDLFEAATGMRMMHNYFRIGGVAADLPYGWIDKCLDFCDYFLRGVIEYQQLITQNPIFLERVEGVGFISGEEAVNWGLSGPMLRASGIQWDLRKVDLYESYNQFDWKVQWQKEGDSLARYLVRIGEMRESIKIIQQAVEKIPGGPYENLEVRRFKKAKNSEWNDFEYRFLGKKPSPNFELSKQELYARVEAPKGELGIYLVGDDSLFPWRWKIRPPGFINLQILPQLVKKMKLADIMTILGSIDIIMGEVDR
Protein: Activated in Blocked Unfolded protein response (O16501)
Organism: Caenorhabditis elegans
Interaction partners:
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Nematode Specific Peptide family, group B
- Activated in Blocked Unfolded protein response
- Prion-like-
Sequence:
MRFTSLAIAFLACALAVSGSAIREKRQCGCAQPQQSQCSCQQVQQTQSCSCQSAPVQQQSPSCSCAQPQQTQQVQVQSTQCAPACQQSCQQQCQASPSVSQCQPQCQQQCQAQCTPMYNPPTTTTTTQAPVVQYQQCQPVCQQQCQSTCVQQQQPAAQCQPQCQQQCNVACDSPSTTTQAPQVIQIQLEIQQAQAQCQPQCQQQCQSSCVQQQQQSNQCEPACNTQCSDICQQTAQATQQVYNQNMNQNTNTQMYNPYNTNTSQNANCAPACQPACDNSCTSQQTQPMYQQYDTTTEAPAQVIQIVLQTSVAQSSQCAPQCEQSCQQQCVQQQQPAAQCQTACQSSCSNSCQTAQPATTACQQSPQQSSCSCQANYSPCGNGQCCRRK
Protein: Protein-L-isoaspartate O-methyltransferase 1 (AtPIMT1) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) (Q42539)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Contributes to seed longevity and germination vigor by limiting the abnormal accumulation of the L-isoaspartyl residues in seed proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15347786}.
Interaction partners:
- SEED MATURATION PROTEIN 1
Sequence:
MKQFWSPSSINKNKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTDRSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEKHLKPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASPFLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAAAPEIPEALIDQLKPGGRLVIPVGNIFQDLQVVDKNSDGSVSIKDETSVRYVPLTSREAQLRGD
Protein: Chemotaxis protein CheY (Q56312)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- CheY-P phosphatase CheC
- Chemotaxis protein CheA
- Chemotaxis protein CheW
- CheY-P phosphatase CheX
- Methyl-accepting chemotaxis protein
- Methyl-accepting chemotaxis protein
- Purine-binding chemotaxis protein
- Flagellar motor switch protein FliM
- Methyl-accepting chemotaxis protein 4
- CinA-like protein
Sequence:
MGKRVLIVDDAAFMRMMLKDIITKAGYEVAGEATNGREAVEKYKELKPDIVTMDITMPEMNGIDAIKEIMKIDPNAKIIVCSAMGQQAMVIEAIKAGAKDFIVKPFQPSRVVEALNKVSK
Protein: Aquaporin TIP2-2 (Tonoplast intrinsic protein 2-2) (ZmTIP2-2) (ZmTIP2;2) (Q9ATL8)
Organism: Zea mays (Maize)
Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Subcellular location: Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Tonoplast.
Interaction partners:
- Aquaporin SIP1-1
- Aquaporin SIP1-2
Sequence:
MVKLAFGSVGDSFSVTSIKAYVAEFIATLLFVFAGVGSAIAFGQLTNGGALDPAGLVAIAVAHALALFVGVSVAANTSGGHLNPAVTFGLAVGGHITVLTGLFYWVAQLLGASVACLLLRFVTHGKAIPTHGVSGGTTELEGVVFEIVITFALVYTVYATAADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVAAADFAGNWVYWVGPLIGGGLAGLVYGDVFIGGSYQQVADQDYA
Protein: L-alanyl-D-glutamate peptidase (EC 3.4.24.-) (Endolysin) (Lysozyme) (Q6QGP7)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Endolysin with L-alanyl-D-glutamate peptidase activity that degrades host peptidoglycans and participates with the holin in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer by hydrolyzing the link between L-alanine and D-glutamate residues.
Interaction partners:
Sequence:
MSFKFGKNSEKQLATVKPELQKVARRALELSPYDFTIVQGIRTVAQSAQNIANGTSFLKDPSKSKHITGDAIDFAPYINGKIDWNDLEAFWAVKKAFEQAGKELGIKLRFGADWNASGDYHDEIKRGTYDGGHVELV
Protein: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6 (General control non-derepressible protein 10) (Protein gcd10) (tRNA(m1A58)-methyltransferase subunit trm6) (tRNA(m1A58)MTase subunit trm6) (Q9HGL4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- tRNA
- tRNA
- tRNA
- tRNA
- Multifunctional methyltransferase subunit trm112
- tRNA
- tRNA
- tRNA
- AdoMet-dependent rRNA methyltransferase spb1
- tRNA
Sequence:
MLRHASTISENSSVFIKLPSDNVRFVTLKPNNTIHLGKFGSFLADDLFGKHFDETFEIYQPKKIRVLKTREVQYIEEEKKTNQELNDCRGNQLMTQEEIDELRANIKAGGLRAEEAIKQLTNSSKTFEQKTLFAQEKYVTRKGEKYLQRFQVLRPCVEVVANYMIEHDPYKILDLTAECISLMLTLGNVKPGGRYLVVDETGCMFLGSLIDRVAGDCKITLVHPNEQPNSSCLEYWGQDFKEDSLVQKGILKTLNWYQVTNPTETLSEYSVEDIPESELNEMKLRHRKRYETKKATFNRLKNTIDDFESGNYDALFILSIHTPMSVLQHLLPKLGISRPFMVYSTYQQVLVETYHQLSKWDNLFVEKTAQSTENDEKVDQGDVAIDTQKEKVIMLDIHEIRTRPYQVLPERTHPFMTVRGDMGFVLSGIKVLTSDSNLAAGRFPKRKGQKETSSVKKAKLEN
Protein: Sphingosine kinase 1 (EC 2.7.1.91) (Q18425)
Organism: Caenorhabditis elegans
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable).
Subcellular location: Presynaptic cell membrane {ECO:0000269|PubMed:22588719, ECO:0000269|PubMed:23223309}. Cell projection, axon {ECO:0000269|PubMed:24929359}. Perikaryon. Mitochondrion membrane. Note=Recruitment to the presynaptic membrane may be regulated by endogenous acetylcholine, which activates a muscarinic signaling pathway acting through gar-3, egl-30 and unc-73. Muscarinic-mediated recruitment of sphk-1 to presynaptic terminals requires calcium influx and the calcium-binding protein calm-1. Primarily observed on the outer surface of mitochondria in body wall muscles. {ECO:0000269|PubMed:22588719, ECO:0000269|PubMed:23223309}.
Interaction partners:
- Acid ceramidase
- Probable acid ceramidase
- Ceramide synthase hyl-2
- Sphingosine-1-phosphate lyase
- sphinganine-1-phosphate aldolase
- Ceramide synthase hyl-1
- Alkaline ceramidase
- Probable ceramide synthase lagr-1
- Serine palmitoyltransferase 1
- Putative sphingolipid delta
Sequence:
MFIVVVTIFENYTQWYSSLLTIFSLTIKRKLKTIRSMQDSTSKCTCTEHHMGGTICCCCRSDAEENEQLTSVILSRKPPPQEQCRGNLLVFINPNSGTGKSLETFANTVGPKLDKSLIRYEVVVTTGPNHARNVLMTKADLGKFNGVLILSGDGLVFEALNGILCREDAFRIFPTLPIGIVPSGSGNGLLCSVLSKYGTKMNEKSVMERALEIATSPTAKAESVALYSVKTDNQSYASFLSIGWGLMADIDIDSEKWRKSLGHHRFTVMGFIRSCNLRSYKGRLTYRPYKPKGFHPSSNVFSVYEKTTQQRIDDSKVKTNGSVSDSEEETMETKFQNWTLPDSDETLAVGSSDLEETVVIEDNFVNIYAVTLSHIAADGPFAPSAKLEDNRIHLSYILWKDIGTRVNIAKYLLAIEHETHLDLPFVKHVEVSSMKLEVISEGSHVVLDGEVVDTKTIEVASTKNHISVFSSTA
Protein: L-amino acid-D/L-Glu epimerase (EC 5.1.1.-) (L-Xxx-D/L-Glu epimerase) (Q30PM2)
Organism: Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Function: Catalyzes the epimerization of dipeptides with L-Glu in the second position. Has epimerase activity with L-Gly-L-Glu, L-Ala-L-Glu, L-Ser-L-Glu, L-Pro-L-Glu, L-Val-L-Glu, L-Met-L-Glu, L-Thr-L-Glu and L-Phe-L-Glu (in vitro).
Interaction partners:
- DUF4476 domain-containing protein
Sequence:
MKIVNITTQVESIELKTPFKTALRQTSHVEFVRVEVECDNGFVGIGEASATKVITGEDIYIILTSIASVEELFLNLTCEEALGALHTKCAIGSSAKASLDIAFVHLLSQEAKKPLYEYFGATDKSALKSDITISLNEADVMLNDAKKAFSNGMDILKIKVGSDILHAIDIVRKIAKELPECDILVDANQAWSFENTVLFIENMLNTPIKLIEQPVEAPNLDGLKKITELSHIPILADEAVFTLKDAKKVIEEKCADMINIKLMKCGGVSKAIEILEFARNREFKCMLGSMLEGPYSINMALHLAFAYRDVIEFVDLDSPLLYKEMPKELDFVFDGCEIKPL
Protein: Low-affinity phosphate transporter PHO90 (P39535)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low-affinity phosphate transporter involved in the control of cellular phosphate levels.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Inorganic phosphate transporter PHO84
- Phosphate permease PHO89
- Phosphate system positive regulatory protein PHO81
- Phosphate system positive regulatory protein PHO4
- Putative cyclin-dependent kinase inhibitor SPL2
- Cyclin-dependent protein kinase PHO85
- Protein SYG1
- PHO85 cyclin PHO80
- Glycerophosphocholine phosphodiesterase GDE1
- Tryptophan synthase
Sequence:
MRFSHFLKYNAVPEWQNHYMDYSELKNLIYTLQTDELQVGDNEEGFGAGKSSNITDRFKNKFSFKNAKEDTSSGMNKDAGIVEETIELRELPTAQTVAAKPSPFRRMKEKIFYKRRSSSASSVSSTANENLQLDTYDTFVGDLTAEKQKVDDFYKRTEAKFYDKFDALVKDLKKIGVIEYDIDDDTLFNEPIASTNDEVPPLDLDDDEDDDEFYDDQSNIEDNTALLHHSQYNIKSQKKSLLKKSIVNLYIDLCQLKSFIELNRIGFAKITKKSDKVLHLNTRTELIESEQFFKDTYAFQAETIELLNSKISQLVTFYARITDRPHNISHSKQELKSYLHDHIVWERSNTWKDMLGLLSQADELTPKETEYNANKLVGKLDLEYYRWPLPRPINLKFTSINNVALPKLFFTKKAYKIYFIILVTGLLLGIKTFNDAAQHRCMALVECVAFLWASEAIPLHITAFLVPLLVVLFKVLKTSDGAIMSAASASSEILAAMWSSTIMILLAGFTLGEVLAQYNIAKVLASWLLAFAGCKPRNVLLMAMCVVFFLSMWISNVAAPVLTYSLLSPLLDAMDADSPFAQALVLGVALAANIGGMSSPISSPQNIISMSYLKPYGIGWGQFFAVALPSGILAMLLVWILLFTTFKMNKTKLEKFKPIKTKFTVKQYYIITVTVATILLWCVESQIEGAFGSSGQIAIIPIVLFFGTGLLSTQDLNAFPWSIVILAMGGIALGKAVSSSGLLSTIAKALQKKIENDGVFAILCIFGILMLVVGTFVSHTVSAIIIIPLVQEVGDKLGNPKAAPILVFGCALLSSCGMGLASSGFPNVTAISKVDRKGDRYLSVMTFLTRGVPASILAFLCVITLGYGIMASVVKGNATSA
Protein: At3g60680 (DUF641 family protein (DUF641)) (Q9LZZ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MREVETTAITAAPPQFSQMFQKLAMAVKTKTYEFFTEDDNERTDAEGFSLLDSSEDFITDQKVVVLKPDKPLLSASSPGSPIESPVNDVQTKNLGVVSVVKPNQKKLSQVRKLDTQMGLSLISSVFATASSFEASYLQLQAAHAPFVEENVKAADRALVSNLQKLSDLKQFYRNYRQSLDFESDLAIGSCLESRVQENQSKLRALETVSNRLQAEMDAKDLQVWSLRNKLGEIQKSTSKLSKRLSSNSSLDVLLSVRVFESLLYDAFKATQKFTKILIELMEKAGWDLDLVAKSVHPEVDYAKERHNRYALLSYVCLGMFRGFDGEGFDLNENDYEESERSSVDSSLRELMQHVSSNPMELLDRDKDCAFSRFCDKKYHELIHPNMASSIFSNMDENEAVLSSWRSLSTFYESFVTMASSIWTLHKLALSFDPAVEIFQVESGVEFSIVFMENVLKRKQDKKFSMSPTRAKVGFTVVPGFKIGCTVIQCQVYLTGGSKM
Protein: Prefoldin subunit 3 (Protein merry-go-round) (von Hippel-Lindau-binding protein 1) (Q9VGP6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22451918}.
Interaction partners:
- Probable prefoldin subunit 6
- Probable prefoldin subunit 5
- Probable prefoldin subunit 2
- Probable prefoldin subunit 4
- GEO07746p1
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- AT18965p
- Kynurenine formamidase
- T-complex protein 1 subunit beta
Sequence:
MTGIMDSVEMPKLPENQKTFAGIPEAVFLEEIDTFMSQPENENCEKVLQRLDEQHGKYRFMACNLEARRRKLKSQIPDLERSLEMVNVLRKEDEERETQFLLSDQVFIKTLVPPTKTVYLWLGASVMLEYPLDEAEALLNQNITSAVGNLKSVEHDQDFLRDQITTTEVNMARVYNWGVKKRQAATKTTATTPS
Protein: Small RNA degrading nuclease 1 (EC 3.1.-.-) (A3KPE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 3'-5' exonuclease degrading single-stranded small RNAs.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- UTP:RNA uridylyltransferase 1
- Protein HESO1
- Inactive exonuclease DIS3L2
- Protein HASTY 1
- 5'-3' exoribonuclease 2
- Nucleotidyltransferase
- Small RNA 2'-O-methyltransferase
- Protein argonaute 10
- Ribosomal RNA-processing protein
- Zinc finger CCCH domain-containing protein 57
Sequence:
MELKLATAEKQVLDELVKLLQSRDLRGENGNWKEFLHVYDKNADSPSDPSRRSHEDLVQFLTTFKKKEDLQLLKCHANHLLIENLKQESQDEDTPEQMLVRLTVEHPSYSLDYSFKPYSEDWFVSDVGMKMKKVMESTNMVAVDCEMVLCEDGTEGLVRVGVVDRDLKVILDEFVKPNKPVVDYRTDITGITAEDIENASLSVVDIQETLQPFLSTGTILVGHSLNRDLEVLKIDHPKVIDTALVFKYPNTRKLRRPSLNNLCKSILGYEVRKTGVPHDCVHDASAAMKLALAVVEKRVDTTIKPSKEMLEVEKAKLFLHKIPNNVPSEELEQVLSGKFTLDVKQAKTQGRYYCAFALFHSSEDADQAFEHIDGIEMTDSLGLPQKVVIIKLSSGSRASIYVRKMVQDE
Protein: Coiled-coil domain-containing protein 85C (A6NKD9)
Organism: Homo sapiens (Human)
Function: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity).
Subcellular location: Cell junction, tight junction {ECO:0000250|UniProtKB:E9Q6B2}. Cell junction, adherens junction {ECO:0000269|PubMed:25009281}. Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall. {ECO:0000250|UniProtKB:E9Q6B2}.
Interaction partners:
- Transcriptional coactivator YAP1
Sequence:
MAKPAATAAAASEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERAALAATGAASGGGGGGGGAGSRSSIDSQASLSGPLSGGAPGAGARDVGDGSSTSSAGSGGSPDHHHHVPPPLLPPGPHKAPDGKAGATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRQLESKVRLLEGDKLLAQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQDSLQNGPACPAPELPSPPSAGYSPAGQKPEAVVHAMKVLEVHENLDRQLQDSCEEDLSEKEKAIVREMCNVVWRKLGDAASSKPSIRQHLSGNQFKGPL
Protein: DDAH family member 2, ADMA-independent (N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (Q5SSV3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPG