wanglab/gogpt-training-data huggingface dataset:
Protein: N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit Naa10) (Q9QY36)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (By similarity). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (By similarity). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (By similarity). Acetylates HIST1H4A (By similarity). Acts as a negative regulator of sister chromatid cohesion during mitosis (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12888564}. Nucleus {ECO:0000250|UniProtKB:P41227}. Note=Also present in the free cytosolic and cytoskeleton-bound polysomes. {ECO:0000250|UniProtKB:P41227}.
Interaction partners:
- N-alpha-acetyltransferase 50
- N-alpha-acetyltransferase 15, NatA auxiliary subunit
- N-alpha-acetyltransferase 16, NatA auxiliary subunit
- Huntingtin-interacting protein K
- N-alpha-acetyltransferase 25, NatB auxiliary subunit
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- N-alpha-acetyltransferase 30
- Calcineurin B homologous protein 3
- N-alpha-acetyltransferase 20
- N-alpha-acetyltransferase 60
Sequence:
MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALHLYSNTLNFQISEVEPKYYADGEDAYAMKRDLTQMADELRRHLELKEKGKHMVLAALENKAENKGNVLLSSGEACREEKGLAAEDSGGDSKDLSEVSETTESTDVKDSSEASDSAS
Protein: Beta-2-microglobulin (Q91202)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKTVLSVIAFCVFLGFINAKESPPKVQVYSRNPGQHGKDNTLICHVSGFHPPDISIQLLKNGVEIPDAKQTDLAFEQGWQFHLTKSVGFTPASGEEYTCRVRHLKNLKTYTWEADM
Protein: Putative cyclic nucleotide-gated ion channel 9 (Cyclic nucleotide- and calmodulin-regulated ion channel 9) (Q9M0A4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative cyclic nucleotide-gated ion channel.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cysteine-rich receptor-like protein kinase 40
- MND1-interacting protein 1
- Calmodulin-like protein 8
Sequence:
MLDCGKKAVKSQVISGRLEKFVRLDSMDSRYSQTSDTGLNRCTLNLQGPTRGGGAQGNNVSSGSFKKGFRKGSKGLWSIGRSIGLGVSRAVFPEDLKVSEKKIFDPQDKFLLLCNKLFVTSCILAVSVDPLFLYLPFVKDNEKCIGIDRKLAIIATTLRTVIDAFYLFHMALRFRTAFVAPSSRVFGRGELVIDPAQIAKRYLQQYFIIDFLSVLPLPQIVVWRFLYISKGASVLATKRALRSIILVQYIPRFIRLYPLSSELKRTAGVFAETAWAGAAYYLLLYMLASHIVGAIWYLLALERYNGCWTKVCSNSSLDCHRNFLFCGNEKMDGYAAWTTIKDSVLQLNCPVNTTDNPPFDFGIYLRALSSGIVSSKSFVSKYFFCLWWGLQNLSTLGQGLETSTYPGEVIFSIALAIAGLLLFALLIGNMQTYLQSLTIRLEEMRVKRRDSEQWMHHRMLPPELRERVRRYDQYKWLETRGVDEENLVQNLPKDLRRDIKRHLCLALVRRVPLFENMDERLLDAICERLKPCLYTESSYLVREGDPVNEMLFIIRGRLESVTTDGGRSGFFNRSLLKEGDFCGEELLTWALDPKSGSNLPSSTRTAKALTEVEAFALIADELKFVASQFRRLHSRQVQHTFRFYSQQWRTWAAIFIQAAWRRYVKKKKLEQLRKEEEEGEGSVTSIRATFLASKFAANALRKVHKNRIEAKSTIELVKYQKPSEPDFSADDTS
Protein: Cyclin-D1-binding protein 1 homolog (Zebrafish homolog of Maid) (A3KNI7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May negatively regulate cell cycle progression.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MSAENSRSEALLPLRNLWNSVKCSRDRVRDGESNDSSGTFSLANFWEILNEAVKAVSQEATKLSLMFSKPPLPSDEDCAKMGECVQKSVLTLCTVYFWLPKSQGVTLRRSVRDATAEVLEGLVQLLDVILSSPGQSLSQEQLTSTGSVWAACDHFDQIPKDNRSAVLAVLSSCVGLVKDALEEMQQALAESQDPFGDVLDDDDDDEGGRGNQDRYWSASDRQLIGQCEGLLKASAASLRKLSSAVRHNAQLETEQEIAQLDDLADAAAHVSPCVDDLALSLYPPVDRAAVEQNVCRLAAVLKKLLDITRSSHVCAEADVSWVEFLSGAVEHNLEKVRSLLRSDS
Protein: AT5g26280/T19G15_130 (TRAF-like family protein) (Q93Z83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNNQKWSIGFISLAFLFITSSSAEFIIQQVTKGRGIEYNSSYSLEENLGVTRELREERPSSKIVTITSFSVIKGRGEPYESSVFEAAGYKWRLVLYVNGNKNDGGNDHISLYARIEETNSLPLGWEVNVDLKLFVHNGKLHKYLTVTDGLVKRYNNAKKEWGFGQLIPRSTFYNANEGYLDQDTGSFGAEIFIVKPAQQQEKVTFISNPPNNVFTWKILRFSTLEDKFYYSDDFLVEDRYWRLGFNPKGDGGGRPHALPIFLFAQGHKANAVATNTWGAVNLRLKNQRSTNHRQIYSAAWYPIGSGYGVGVNNIILLADLNDASKGYLVNDAIIFEAEMVKVSITNIVSA
Protein: Corolla, isoform B (X2JKX2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEKYPLVKEFMGQNWPKDTKMAQLEKELKKRKELIVEEQRPRLEQVLFDLTLVKQCALVVEDNGAGMAQANTMIQDCMFQITRIEELLEMAGLQDILYYTVHRKEQEFQRKIKLQEDLAEQENQQNTILESRSIVQEFRKEQALKKEADKELASVDDQLDQSDREWTITLRSMTDKLNKKIVSVLQMGKLINELKEELQKRNLIKTGVTKGAEPSLAGVPSASTISPFQSASDFLNNFIFKNIRPDDNKSMTSVNREITTKKLETPLRSILIKCKEVESVAISNSPTKQVRFSPYPEISHIEEEKFEKTDWLSPSEEAGVPNAELEEDSDEMEATDEDFEEISEEEFEMALKDEGFEQEVKVEKSEEVLHLEQDRYDEKSGSEVEESVSDDKESGGEASGEEEPADAAKQVKIGENPKTDEQLSNEISDKPQIIRVDTLSPFKNISSWASDDIPSTSKGTLNRFTATQFMNYGSNRDENEAPPCKRLKLEEEEFPMSQPMPDYFKHPSSTFNNFDDQSLRFSSPHNNFDDDYLLNFSDDNDVTPTAASAYIL
Protein: Polyphenol oxidase latent form, chloroplastic (L-PaPPO) (PA-PPO) [Cleaved into: Polyphenol oxidase active form, chloroplastic (A-PaPPO) (EC 1.10.3.1)] (O81103)
Organism: Prunus armeniaca (Apricot) (Armeniaca vulgaris)
Function: Catalyzes the oxidation of mono- and o-diphenols to o-diquinones. Uses preferentially 4-methylcatechol and chlorogenic acid as substrates, followed by caffeic acid, pyrogallol, and catechol, but barely active toward dopamine and L-dopa. No activity detected with monophenols (e.g. phenol and tyramine).
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000250|UniProtKB:Q6UIL3}.
Interaction partners:
Sequence:
MATAPSPTTMGTYSSLISTNSFSTFLPNKSQLSLSGKSKHYVARRSSISCKATNNNNSNNQNEQQEESSRLLGKLDRRNILIGLGGLYGATTLDRKPFAFADPIAPPDLTTCKPAEITPGGSETVPCCPPVTTKIKTFKPDLSIPLRTSPAAHQVTDEYLAKFKKAQAAMRALPDDDPRSMVQQAKVHCAYCNGAYPQVGFTDNDIQVHFSWLFFPFHRMYLYFYERILGKLIDDPTFALPYWNWDSPVGFPIPDIYTDTSSPLYDQYRNADHQPPVLVDLSYGGKDDDVDEQTRIDENLAIMYRQMVSGAKTPDLFFGHAYRAGNLNTGKYPGTIENMPHNNIHIWVGDPSQTHQEDMGNFYSAGRDPLFYAHHANVDRMWNIWKTLGGKRKDITDTDWLDAEFLFYDENAELVRVKVRDSLEPEKQLRYNYEPVSLPWLFTKPTARKTKNKTKAKVAATQLTSKFPATLVEVTTVEVARPKPRKRSKKEKVDEEELLIIKDIEFEGTEAVKFDVFINDDAESLSRRDKSEFAGSFVHVPQGKTTKAKTKTNLKLGITDLLEDLGAEDDSSVLVTLVPRVSNSPITIGGFKIEYSS
Protein: Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) (Q8VI33)
Organism: Mus musculus (Mouse)
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. Essential for cell viability. May have a role in gene regulation associated with apoptosis.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 6
- TATA-box binding protein associated factor 4
- Histone acetyltransferase KAT2A
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 2
Sequence:
MESGKMASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKATVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQRNQTPLPLIKPYSGPRLPPDRYCLTAPNYRLKSLQKKAPAPAGRITVPRLSVGSVSSRPSTPTLGTPTPQTMSVSTKVGTPMSLTGQRFTVQMPASQSPAVKASIPATSTVQNVLINPSLIGSKNILITTNMVSQNTAESANALKRKREDDDDDDDDDDDDDYDNM
Protein: Cathepsin W (EC 3.4.22.-) (Lymphopain) (P56202)
Organism: Homo sapiens (Human)
Function: May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:11490002}.
Interaction partners:
- Apoptosis regulator Bcl-2
- BH3-interacting domain death agonist
- Bcl-2-like protein 1
- Protein NKG7
- Granulysin
- Granzyme H
- Perforin-1
- T-cell surface glycoprotein CD8 alpha chain
- Granzyme A
- Natural killer cells antigen CD94
Sequence:
MALTAHPSCLLALLVAGLAQGIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLTARVQKPDMKPRVSCPP
Protein: Histamine N-methyltransferase (HMT) (EC 2.1.1.8) (Q91VF2)
Organism: Mus musculus (Mouse)
Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P50135}.
Interaction partners:
- Amine oxidase
- Diamine oxidase [copper-containing]
- Amine oxidase
- Amine oxidase
- Histidine decarboxylase
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
Sequence:
MASCMRSLFSDQGRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGEAKAEIKILSVGGGAGEVDLQILSKVQAQYPGICINNEVVEPSAEQIVKYKELVAKTSNMENIKFSWHKETSSEYQKRMLEEEEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAASAKILIILVSGTSGWEKLWKKYGSRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLVSTMDITDCFIDGNENGDLLWDFLTETCNFSKTAPLDLKAEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV
Protein: Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26) (O43790)
Organism: Homo sapiens (Human)
Interaction partners:
- Desmoglein-4
- Keratin, type II cuticular Hb1
Sequence:
MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGVCGGSCKRC
Protein: Glycerophosphodiester phosphodiesterase, periplasmic (Glycerophosphoryl diester phosphodiesterase, periplasmic) (EC 3.1.4.46) (P09394)
Organism: Escherichia coli (strain K12)
Function: Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
Subcellular location: Periplasm {ECO:0000269|PubMed:2829735}.
Interaction partners:
- Glycerol-3-phosphate transporter
- Glycerophosphodiester phosphodiesterase, cytoplasmic
- Glycerol uptake facilitator protein
- Glycerol kinase
- Anaerobic glycerol-3-phosphate dehydrogenase subunit A
- Aerobic glycerol-3-phosphate dehydrogenase
- Anaerobic glycerol-3-phosphate dehydrogenase subunit C
- Anaerobic glycerol-3-phosphate dehydrogenase subunit B
- Lysophospholipase L2
- Ethanolamine ammonia-lyase large subunit
Sequence:
MKLTLKNLSMAIMMSTIVMGSSAMAADSNEKIVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDNLVVLHDHYLDRVTDVADRFPDRARKDGRYYAIDFTLDEIKSLKFTEGFDIENGKKVQTYPGRFPMGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMELNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKLPEYTPDVNQLYDALYNKAGVNGLFTDFPDKAVKFLNKE
Protein: FCS-Like Zinc finger 5 (Q8VY80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:24600465}. Cytoplasm {ECO:0000269|PubMed:24600465}. Note=Shuttles from the cytoplasm to the nucleus when associated with KIN10. {ECO:0000269|PubMed:24600465}.
Interaction partners:
- FCS-Like Zinc finger 16
- Large ribosomal subunit protein P2x
- AT3g20100/MAL21_14
- AT4g23680/F9D16_150
- B3 domain-containing protein REM20
- Cellulose synthase-like protein E1
Sequence:
MLLGKRQRPPIKRTTSLSEIKFDLNQPSEQEPSDHQIQLVNVDEHRQVHQRLLDQRLLAMVSPRGTQRRHSSDYSEDFLRSCSLCKRLLVHGRDIYMYRGDRAFCSLECRQQQITVDERKEKKKGSVRSTIVVATGTTTGERVSAAV
Protein: Kynurenine aminotransferase, putative (Q389E5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Kynureninase
- aspartate transaminase
- Aspartate aminotransferase
- Cystathionine beta-synthase, putative
- Adenosylhomocysteinase
- Homocysteine S-methyltransferase, putative
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- Mercaptopyruvate sulfurtransferase, putative
- Homoserine kinase, putative
- DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein
Sequence:
MQQSIRLADRLADVPPYSVWTEMTPLANKHGAVNLGQGFPNFPPPDFLLKEAHRVFDESVVTPTNQQYARTQGNLELVSELKRIYAKHLGWPDIGDENIVITNGTTQGLNMVFQAIVNPGDEVITFEPFYDAYQCDIQLAGGVVRFVQMIPGSTGLADSWTFSEEQLRSLINPRTKAILVNTPQNVPGKAWTREEMNIVASLALEHNLIVVSDEVYMHLVYATPHPIEGQKHSHLSIAALPDMRDRCVTLCSSGKTFSATGWKIGWAVGPTKLIQALSLLELYQTFNVATPLQIATARGLRIAEEVGYYENLLSQYEKRRKLLCDMLAKNNLPPTIPSGGFFVLADISLVDPKHYLDPNERSVGRDWQFCRWLTRTLKVCAIPVTAFCQKENRPVYDKFVRFAYCKKEEDIIEAGIRLERLSEYLLPAH
Protein: Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) (Q9C6I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Involved in leucine catabolism and in phytol degradation (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:14671022, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
- Electron transfer flavoprotein subunit beta, mitochondrial
- At1g50450/F11F12_20
- Isovaleryl-CoA dehydrogenase, mitochondrial
- Acyl-coenzyme A oxidase 4, peroxisomal
- Peroxisomal acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase 2, peroxisomal
- Putative acyl-coenzyme A oxidase 3.2, peroxisomal
- Putative peroxisomal acyl-coenzyme A oxidase 1.2
- Putative acyl-coenzyme A oxidase At3g06690
Sequence:
MTRTVLLRALTKNKFVASNAPRSISISITSLSRCISTLILAEHESGTIKPQTVSTVVAANSLGESSSISLLLAGSGSSLQEAASQAASCHPSVSEVLVADSDKFEYSLAEPWAKLVDFVRQQGDYSHILASSSSFGKNILPRVAALLDVSPITDVVKILGSDQFIRPIYAGNALCTVRYTGAGPCMLTIRSTSFPVTPITANSESKKATVSQIDLSNFEDDSVSKSRYVGRSTQDTERPDLGSARVVITGGRALKSVENFKMIEKLAEKLGGAVGATRAAVDAGYVPNDLQVGQTGKIVAPELYMAFGVSGAIQHLAGIKDSKVIVAVNKDADAPIFQVADYGLVGDLFEVIPELLEKLPEKK
Protein: AT17867p (Mig-2-like GTPase Mtl) (Mig-2-like, isoform A) (Mig-2-like, isoform B) (Mig-2-like, isoform C) (Small GTPase) (Q7JWS8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rho GDP-dissociation inhibitor 3
- non-specific serine/threonine protein kinase
- Mitogen-activated protein kinase kinase kinase
- Stress-activated protein kinase JNK
- Myoblast city, isoform B
- Guanine nucleotide exchange factor MSS4 homolog
- Rho-associated protein kinase
- non-specific serine/threonine protein kinase
- RE12101p
- Protein vav
Sequence:
MSTGRPIKCVVVGDGTVGKTCMLISYTTDCFPGEYVPTVFDNYSAPMQVDTIQVSLGLWDTAGQEDYDRLRPLSYPQTDVFLICYSVASPSSFENVTSKWYPEIKHHCPDAPIILVGTKIDLREDRETLSGLAEQGLTPLKREQGQKLANKIRAVKYMECSALTQRGLKPVFEEAVRAVLRPEPLKRRQRKCLIM
Protein: 26S proteasome non-ATPase regulatory subunit 6 (Q7ZWE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPLENLEEEGLPKNPNLRIAQLKFLLTHRQDAQVKSELMDAIKLNNMAPYYETLCKELKWQADTDLLSKMKKANEDELKRLDDVLEDAEKNLGESEIRDAMMAKAEYLIRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVCMIALKRPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLARVEQEMKQDWLFAPHYRYYVREMRILAYSQLLESYRSLTLGYMAEAFGVSTEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM
Protein: Wdr62 protein (Q3MHU0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
PSEIRSLSPGEQTEDEMEEECEPEETLKTPSKESLDPDPRCLLTNGKLPLWAKRLLGDDDVTDSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWALDSYFTPMKPGNLEDSVLDSVEPQNLAGLLSESGSPKEDSRGHPSYLPLQREGTETRELILCSPEVEVTVTGMHREYYEEAEAGPEDQQGDSYLRVSSVSSKDQSPPEDSGESEAELECSFAAAHVSAPRTDPGPHLTMTEHSSTDELAQPGVPGLGNGSLPQTPEQEKFLRHHFETLTDAPAEELFPGSLGDIKISETDDYFFNPRLSISTQFLSRLQKTSRFPPRLPLHLMKSPEVQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQMAEETPEASCLPTPPITGLASCVPPSSVIPTDRKPPTPTSGLTTGREQSIPAPSPCSYLESTTSSHAKMTRSTSLGDSEGPVTGELPRPLHKPVSPGQEPQAVPTTVALTSSVKGHEPALPAWGNHEARASLRLTLSSVCEQLLSPPQLEPPTTPVWSQEAVDVPPSMAVTVASFSAPSPEDMSTLGLHSSVFLPKTSASGPLTPPAHPNSLQLLETRSRMPGSTPALLEPTPDASSGSPDSPGHCGEPGRRAEVPPPGPLELDSVESVLYRLQTAFQEALDLYRMLASSNQLGAEQQQAQTELASAFHWIHHQLEASNCVGAASVAPPLTLPSPGPPSPPTLCPLASPNLQALLEHYSELLVQAVRRKVRGD
Protein: Ran GTPase-activating protein 1 (RanGAP1) (P46060)
Organism: Homo sapiens (Human)
Function: GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15037602, ECO:0000305|PubMed:8146159}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8146159}. Nucleus envelope {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11854305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}.
Interaction partners:
- Small ubiquitin-related modifier 1
- E3 SUMO-protein ligase RanBP2
- GTP-binding nuclear protein Ran
- Small ubiquitin-related modifier 2
- SUMO-conjugating enzyme UBC9
- Ran-specific GTPase-activating protein
- RANBP2-like and GRIP domain-containing protein 2
- Sentrin-specific protease 1
- Regulator of chromosome condensation
- Sentrin-specific protease 2
Sequence:
MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV
Protein: PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Q60636)
Organism: Mus musculus (Mouse)
Function: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
Subcellular location: Nucleus {ECO:0000269|PubMed:8168136}. Cytoplasm {ECO:0000250|UniProtKB:O75626}.
Interaction partners:
- Histone-lysine N-methyltransferase EHMT2
- Interferon regulatory factor 4
- Paired box protein Pax-5
- Histone deacetylase 2
- Signal transducer and activator of transcription 3
- Basic leucine zipper transcriptional factor ATF-like
- T-box transcription factor TBX21
- Transcription regulator protein BACH2
- Interleukin-7 receptor subunit alpha
- X-box-binding protein 1
Sequence:
MREAYLRCWIFSWKNVWVRPCQRLHFKTVLLQGSLLYTALDSYSTVQAAPKSSSGSVKFQGLAETGIMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTVINLTQTESNPKQYSSEKNELYPKSVPKREYSVKEILKLDSNPSKRKDIYRSNISPFTLEKDMDGFRKNGSPDMPFYPRVVYPIRAPLPEDFLKASLAYGMERPTYITHSPLPSSTTPSPPASSSPEQSLKSSSPHSSPGNTVSPLAPGLPEHRDSYSYLNVSYGSEGLGSYPGYAPAPHLPPAFIPSYNAHYPKFLLPPYGISSNGLSTMNNINGINNFSLFPRLYPVYSNLLSGSSLPHPMLNPASLPSSLPTDGARRLLPPEHPKEVLIPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPKATSSVMAAPSTDGAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSYIHLCSLKVHLKGNCPAGPAAGLPLEDLTRINEEIERFDISDNADRLEDMEDSVDVTSMVEKEILAVVRKEKEETSLKVSLQRNMGNGLLSSGCSLYESSDLSLMKLPHSNPLPLVPVKVKQETVEPMDP
Protein: Sensor-like histidine kinase SenX3 (EC 2.7.13.3) (P9WGK5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the two-component regulatory system SenX3/RegX3 involved in stress response. Autophosphorylates, and then transfers the phosphate group to RegX3 (By similarity). The system is involved in phosphate starvation response. Plays a role in modulating expression of aerobic response and in the regulation of response to hypoxia. Involved in virulence. SenX3 is a key regulator of mycobacterial replication in response to oxygen, nitric oxide (NO) and carbon monoxide (CO), and acts as an O(2) sensor that plays an important role in the reactivation of growth in response to the restoration of aerobic conditions.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sensory transduction protein RegX3
- DNA-binding response regulator MtrA
- Transcriptional regulatory protein PrrA
- Possible two component system response transcriptional positive regulator PhoP
- Response regulator MprA
- Probable transcriptional regulatory protein TcrX
- Transcriptional regulatory protein TcrA
- Transcriptional regulatory protein TrcR
- Probable transcriptional regulatory protein
- Transcriptional regulatory protein KdpE
Sequence:
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR