wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear intron maturase 1, mitochondrial (AtnMat1) (EC 3.1.-.-) (Nuclear intron maturase 1 a) (AtnMat1a) (Protein CHANGED SENSITIVITY TO CELLULOSE SYNTHESIS INHIBITORS 1) (Q9C8R8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Necessary for mitochondrial biogenesis during early developmental stages. Involved in the splicing of mitochondrial NAD4 transcripts. Required for trans-splicing of NAD1 intron 1 and also functions in cis-splicing of NAD2 intron 1 and NAD4 intron 2. Required for the regulation of fundamental metabolic pathways such as amino acid metabolism, triacylglycerol degradation and polysaccharide synthesis (cellulose and starch) during the early stage of plant growth. Implicated in stress responses.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19946041}.
Interaction partners:
- Nuclear intron maturase 4, mitochondrial
- Nuclear intron maturase 3, mitochondrial
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- Maturase
- Pentatricopeptide repeat-containing protein At1g74900, mitochondrial
- RCC1 domain-containing protein RUG3, mitochondrial
- Transcription termination factor MTERF15, mitochondrial
- Pentatricopeptide repeat-containing protein At3g48250
- Protein WHAT'S THIS FACTOR 9
- DNA repair RAD52-like protein 1, mitochondrial
Sequence:
MKRLTYPLSSLRNIVEHFHCNTFHKPISSLSISPTLKSESREPSSTQDPYSLLKQDPVDICLSLWVKSFSSPPSATFSNLTGFLSKFDLWVLAYQRTCAHVTGTFPPRNAIHANALRSLLSLQNAVTRSGGKFRWNDKMNQYVRSPKDKISMNGGEGMSKGKVRRIIESEEPIFQDRVVHEVLLMILEPFFEARFSSKSHGFRPGRNPHTVIRTIRSNFAGYLWFMKGDVSEMLDHVDVDVVMNCLQKVVKDRKVLGLIESSLKFSDKRVLKRVVEKHGNDNGLGTKRRIEREKRNKTKKKILSDDEPKPDPYWLRTFYSFAPKEAAKVPSYGYCGVLSPLLANVCLNELDRFMETKIVEYFSPCKDDSIWKESIEDGCHNPAWPEFVPSSGKEKTRKMDYIRYGGHFLIGIRGPREDAVKMRKEIIDFCDRVFGVRLDNSKLEIEHISRGIQFLDHIICRRVIYPTLRYTGSGGSIVSKKGVGTLLSVSASLEQCIRQFRRLAFVKGDKDPEPLPCNPMLYSSQSHSNSQMNKFLETMADWYKYADNRKKAVGFCAYVIRSSLAKLYAARYRLKSRAKVYSIASRDLSHPLSESSNNSAPEYSDLLRMGLVDAIEGVQFSRMSLIPSCDYTPFPRNWIPNHEQVLQEYIRLQDPKFFCGLHRSIKREGLTLPQDEISEAVWDFKTLGAWRSKYENKREADDGLQKLDSQT
Protein: Putative mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (LmxPK4) (Q9GRT1)
Organism: Leishmania mexicana
Function: Protein kinase which regulates promastigote proliferation in host macrophages, thereby playing an essential role in parasite virulence.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:15882412}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:15882412}. Nucleus {ECO:0000269|PubMed:15882412}.
Interaction partners:
Sequence:
MPPKRPQALEKLHVEPHDKGVSITDTMTLVVKGEGGVEMRVKQTGIAQGPGSSSAGGQPKSDAVMNKIKFEDLRIGSELGKGSQGKVRVAQHKLTGEKYAMKYIAFDGDSDDMRSALEAELRQVAAVKHHNVVSSYEAFFRDGRLYIVLEYMDCGTMNNLIDRHPEGFSEDMLAYIARELFKGLEFLHHLNMIHRDIKPANVLANTKGEIKISDFGVAKTLSGGDLQTLSAQGSVPYMSPERIQSKPYSFNSDIWSAGLTIAECAFREYPFASLKPKLFELCQAIASGTAKINWDDRETKFSDEFKEFIELCLRPEATRPSATEMLSHSLIQKASNVNPLEAGRWMSRKK
Protein: RNA-binding protein 4F (Q9W4D2)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in gene regulation during development. Binds RNA.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:9434193}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm8
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm3
- Actin maturation protease
- Precursor RNA processing 3, isoform A
- SD09427p
Sequence:
MDADKQLERQLEKELDEMPAEDLDDDAYDEYDLIVIPDQGKGSPQQGHSESPQQEEEHKSEELRQRSRPTWPPSSAGGDMTTIELISSDDEPSVEETEGGNAAGRGRARNDSSSSSDDVGVIEGSELESNSEVSSDSDSDSDNAGGGNQLERSYQELNALPSKKFAQMVSLIGIAFKLNDLEKIESSVLELQNLATVPAHVWLKYLKARLVVTQTDEERKAFEEQCAKALGYYYSIPLSEYVVNYLVDQGNVQNHVLWAKLLADYDVERPDFGDKLRSLISTITDENEAAAFVEMLQKHCVTWTCNVEQRQMIKSVVDKFKQHLDETTRGWDWSEQHKAHVYDVETLSLDDDLKNAVIRFIFERSVAKFPIVDVLWLSYIEFIQFEGVTVPENEDENEVTAEMVAKRAKRLGKGFLRNTELDLANRGVRSHPSVQLNHRFLDLMERSDFELAEVDEEIRLILQRIVTDMDMTVELHLDYLAYRIRNTNASDEQQVASLRAAFNHAWEELTVLYGDQADTRYEVLQLWAQVEYTQLGSPDNGREIWRQIMGYPGSSIRGLLWLNFAQMESEYNGGHGTRDVLRKALSQPVLENGLMVQEFFRRYERCYGTYESIAACQALDLPVEYVKPRSRIKPNSQSAYPRQQKLKPRQQQQQTNREPLNREQRRRQAHEQQQQQQQQQKHGIKKSRTEPSGGATSPPSKVKGPANAEAKESNFKYSPNMEINKIFVRNLHPACSKEELHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGTSAVKPSVAPKRRVPTSLIPTTLVRQEVAAKKLRLLLPEPGDISSTSASVDVAIKREANGEEQKGDVQERDEQKGEEQKGEEQKGEEPKGEEQKGDDQIGEEQSGVEQKGDEKKEEEMPAAVPKSNDDFRKLFLKD
Protein: Adiponectin receptor 2 (G3V707)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- 30 kDa adipocyte complement-related protein
- DCC-interacting protein 13-alpha
- Adiponectin receptor 1
- Leptin
- Cadherin-13
- Nicotinamide phosphoribosyltransferase
- Resistin
- Resistin-like gamma
- Peroxisome proliferator-activated receptor alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Sequence:
MNEPTEHRLGCTRTPEPDIRLRKGHQLDDTRGGNNDNHHGDLEPSLETPVCSSYYENSPEELECHDDNSQEDEGFMGMSPLLQAHHAMERMEEFVCKVWEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFVGLGLSGIIPTLHYVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCTEEDAL
Protein: DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) (Q9UHN1)
Organism: Homo sapiens (Human)
Function: Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P54098}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:P54098}.
Interaction partners:
- DNA polymerase subunit gamma-1
- Ribonucleoside-diphosphate reductase subunit M2 B
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon subunit 3
- DNA polymerase zeta catalytic subunit
- DNA polymerase epsilon subunit 4
- Twinkle mtDNA helicase
- DNA polymerase epsilon subunit 2
- Mitotic spindle assembly checkpoint protein MAD2B
- DNA polymerase alpha subunit B
Sequence:
MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV
Protein: CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) (Q6UUV9)
Organism: Homo sapiens (Human)
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 1
- CREB-regulated transcription coactivator 3
- CREB-regulated transcription coactivator 2
- Mastermind-like protein 2
- Period circadian protein homolog 1
- Mastermind-like protein 3
- Mastermind-like protein 1
- Serine/threonine-protein kinase SIK2
Sequence:
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRVLLLTVPGMEETTSEADKNLSKQAWDTKKTGSRPKSCEVPGINIFPSADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPTFPALSSSSSTGNLAANLTHLGIGGAGQGMSTPGSSPQHRPAGVSPLSLSTEARRQQASPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPASQQPPPPPPPQAPVRLPPGGPLLPSASLTRGPQPPPLAVTVPSSLPQSPPENPGQPSMGIDIASAPALQQYRTSAGSPANQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMAARQANALSHQLEQFNMMENAISSSSLYSPGSTLNYSQAAMMGLTGSHGSLPDSQQLGYASHSGIPNIILTVTGESPPSLSKELTSSLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL
Protein: Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) (Q8IU68)
Organism: Homo sapiens (Human)
Function: Probable ion channel.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12426567, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:25220380}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18158319}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:18158319}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the ER, Golgi and nucleus membranes in keratinocytes. {ECO:0000269|PubMed:18158319}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A1
- Synaptogyrin-2
- Thymidine kinase, cytosolic
- Transmembrane channel-like protein 6
- Calnexin
- Calcium and integrin-binding protein 1
Sequence:
MLLPRSVSSERAPGVPEPEELWEAEMERLRGSGTPVRGLPYAMMDKRLIWQLREPAGVQTLRWQRWQRRRQTVERRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAYRVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLVVGAISAIFWATKYSQDNKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLLGLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASARRFRFPSGAEL
Protein: Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I) (P14578)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00401}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00401}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 2
- Os04g0343050 protein
- Cytochrome b
- Cytochrome b
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
- NAD
- Heme O synthase
Sequence:
MTNLVRWLFSTNHKDIGTLYFIFGAIAGVMGTCFSVLIRMELARPGDQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGAPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGSGTGWTVYPPLSGITSHSGGAVDLAIFSLHLSGVSSILGSINFITTIFNMRGPGMTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSRKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWVGKIFGRTYPETLGQIHFWITFFGVNLTFFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGIRRFFVVVAITSSSGKNKRCAESPWAVEQNPTTLEWLVQSPPAFHTFGELPAIKETKS
Protein: 20S proteasome alpha 7 subunit (Q9NDA3)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSGSGHDQSTDIFSADGRVFQVEYACKAVDNGSTAVAACCKDGVVVAVEKILTSRMLEEGSNNRIHAVDRQAGICVCGVLPDGLAVVSRARGEAENSRDIFSTPILGSLLASRIGEFMHVYTTHYAYRPFGCSVIIASYADDGPQLYVADPSGAVAGYYGIALGKGKTVAKTELEKLDFATLTCSEAVEKLTNILHEVHDKSKDKIYEVEVAWVCDKSDRTFVHVPKEMVPHPTPAS
Protein: 1,4-dihydroxy-2-naphthoyl-CoA thioesterase 1 (AtDHNAT1) (DHNA-CoA thioesterase 1) (EC 3.1.2.-) (Q9SX65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of the thioester bond of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) in peroxisomes, a necessary step to form the naphthoquinone ring of phylloquinone (vitamin K(1)). Is not active on benzoyl-CoA, phenylacetyl-CoA, succinyl-CoA and palmitoyl-CoA thioesters.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19329564, ECO:0000269|PubMed:22372525}.
Interaction partners:
- 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal
- 2-carboxy-1,4-naphthoquinone phytyltransferase, chloroplastic
- 1,4-dihydroxy-2-naphthoyl-CoA thioesterase 2
- Protein PHYLLO
- 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic
- AT4g33900 family protein)
- AT5g37540/mpa22_p_70
- Extracellular ligand-gated ion channel protein
- At1g13195
- Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC
Sequence:
MDSASSNTKAIDPPLHMLGFEFDELSPTRITGRLPVSPVCCQPFKVLHGGVSALIAESLASMGAHMASGFKRVAGIQLSINHLKSADLGDLVFAEATPVSTGKTIQVWEVKLWKTTQKDKANKILISSSRVTLICNLPIPDNAKDAANMLKMVAKL
Protein: Structural maintenance of chromosomes protein (E9PD53)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
Interaction partners:
Sequence:
MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC
Protein: Runt-related transcription factor (Q8UWC8)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009374}.
Interaction partners:
Sequence:
MASNSLFSSVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSEVSPVVVAQQQQQQQQQQQQEAAVPRLRPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVLTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFPERLSDLGRIPHPSMRVGVPTQSPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTSLSFTRGTGLPAITDVPRRLSGASELGPFSDPRQFTSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQNQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQSDGVEADGSHSSSPTVLNSSGRMDESVWRPY
Protein: Methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) (MCM-alpha) (P11653)
Organism: Propionibacterium freudenreichii subsp. shermanii
Function: Catalyzes the reversible conversion of succinyl-CoA to (R)-methylmalonyl-CoA through a radical mechanism. Is involved in the fermentation of pyruvate to propanoate that occurs in Propionibacteria (Probable).
Interaction partners:
Sequence:
MSTLPRFDSVDLGNAPVPADAARRFEELAAKAGTGEAWETAEQIPVGTLFNEDVYKDMDWLDTYAGIPPFVHGPYATMYAFRPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVAGDVGMAGVAIDSIYDMRELFAGIPLDQMSVSMTMNGAVLPILALYVVTAEEQGVKPEQLAGTIQNDILKEFMVRNTYIYPPQPSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATADIEMAYTLADGVDYIRAGESVGLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVHQFGPKNPKSMSLRTHSQTSGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGGMAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLDVLKVDNSTVLAEQKAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDRNLLKLCIDAGRAMATVGEMSDALEKVFGRYTAQIRTISGVYSKEVKNTPEVEEARELVEEFEQAEGRRPRILLAKMGQDGHDRGQKVIATAYADLGFDVDVGPLFQTPEETARQAVEADVHVVGVSSLAGGHLTLVPALRKELDKLGRPDILITVGGVIPEQDFDELRKDGAVEIYTPGTVIPESAISLVKKLRASLDA
Protein: SLC22A23 protein (cDNA: FLJ21380 fis, clone COL03329) (cDNA: FLJ22174 fis, clone HRC00767) (Q7L9D0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALSRRGGPTALLPGQPEEEEAGCLFGGSFSLGIPEAVEQHLYEMLPEQQHFPVGTAPGNPVPSEQGGRTHPSLIRIWARRAQQGRLLRLPTSQHRLSGLNPSVLFPSWLIGRPFAGTHCFNLTLPPPATLLHTPLRSASLPCQPFNKSYAQM
Protein: Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP) (Q3UZ39)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA (By similarity). Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).
Subcellular location: Nucleus. Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein flightless-1 homolog
- Catenin beta-1
- Interferon-activable protein 204
- Probable ATP-dependent RNA helicase DDX41
- ATP-dependent DNA/RNA helicase DHX36
- Myeloid differentiation primary response protein MyD88
Sequence:
MTSPEGAQNKEIDCLSPEAQRLAEARLAAKRAARAEAREIRMKELERQQKEVEERPDKDFAEKGSRNMPSLSAATLASLGGTSSRRGSGDTSISMDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESQRQYEEKNKEFEREKHAHSILQFQFAEVKEALRQREEMLEKHGIILNSEIATNGETSDTVNDVGYQAPTKITKEELNALKSAGEGTLGKAKEVEVKKEIVEKVGQRETLQNSEQEQPKPNTGKDCVDRGVSHPGEKAENQRPAEDSALSPGPLAGAKCEQQVQSQDQENTSDLKNSEQIESHKVTNKSDSRASNSPEQSSCLEGLDSEVPGPTEDLKTDLGKGSFEPCPDYILGQTAEIDKVTCTDSRGTGGNQREDEVQAGDTTVEDQVGTVASGPAKQSKGTENHGESCLKDGLGQSSERELTQEVAEPEEAIVQIPQAGGENTITKADDAEGRDEKPIQAEAQASPGAPINQSGHQDTTGPGSTDAQRTPPHAKERKKQGKSEQQAEALDSPQKKTKNKKKKNKKKKAATPAETCRDANEELNCQDPDVGDMEEEERLQVTDKKQASGSPEQKIRAGSREPVEDPQSGSSGKQNKVEEDGPTEGPTDILDQNSPQCEDREISPVGEKGPQCDTSQIGSEEGHVTSQHGGQAVENHNLDNSDLSGQLEGFNSESGGQAREEVGNSKSKEDCTMS
Protein: Uncharacterized protein C6C3.09 (Q10312)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Ribonuclease P protein subunit rpr2
- Ribonuclease P/MRP protein subunit POP5
- Probable ribonuclease P protein subunit 3
- Probable ribonuclease P protein subunit 1
- Ribonuclease MRP protein subunit rmp1
- Ribonucleases P/MRP protein subunit pop3
- Probable ribonucleases P protein subunit pop8
- Ribonucleases P/MRP protein subunit POP7
- Large ribosomal subunit protein uL30C
- Ribonucleases P/MRP protein subunit pop1
Sequence:
MNCAFTKELKDEIYQKNYTEHEILQNAYNGKLDILLPVEDASEEAIRSITKIVQDLSFYEFSGSPALLLHPDLYSTFIHTGIATIVSSSDNDNKICISQGILSVTLDKDSYLVSGIDAKPSSSEPKDTLWVANIDLKSAFLRPQWKGFERLKAALGRLPGKWSFYLTFPTEKVDQSYQNNLSHSLPVPMISREINLKKGKLDQAKIPPPLVSTLNRNELFPSNGPLEVLEILSFLRCNAKCVQNSFVPDPYISRYKPSCAVTDVLYLSIKGLFSSSTCLELYELIRNISWNFIGVESFNSFRDVDNSSQLHSGDSSLLSFYDSRTERIRWTWRLS
Protein: ADP-ribosylation factor GTPase-activating protein 1 (J9VRH3)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Interaction partners:
Sequence:
MAENYQKKELLALMNIGGNKVCVDCNAPSPQWASVSYGIFICLECSGVHRGFGVHISFVRSITMDKWSEDQLNKMKMGGNEKFKDFMGNYGPEGGYTKGMGMQEKYNSWAAAQYREKLTAECAGQPWSPSSPPANFGLPSRPVSSQTTRKSRAAGGITGSSLNPSRTNSPSIPQGSDDFYGQKSANEAFFERMGNANATRPDHLPPSQGGKYSGFGSAPEPDVASSHPSYSLSSHAAPTLDEFQRNPLGALTKGWGLFSSAIVSAGREINNSVVQPGLDRAQALAAGENSEEWKRYVDQASAQAKDAGGWLGQRAQESWEGLNDVAKTKGGVDLNEKFGRLGLGKSNIPGSRGYGQVGALDKAEDGLLSPHGGGNDDEDFFESWGAAPPASTASAPSGANPITDKGKKKEDEKDEKRKDD
Protein: IP16414p (L(3)mbt interacting protein 1, isoform C) (L(3)mbt interacting protein 1, isoform D) (C6SV09)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRRILDELEEEVYEINAEQQFLLLRLNDSLQEFSVKLKENNIMFLPDIAHEYVSAQVVPLIVDPNYKIMPQSVMARDTEEMLIRKHFLLSQDDDSGMPPLKLSELDENIPLMLAPPVRGLGQQIAAVKPEPEWLQGDEATVSVPPPPPQSKSKLMKGSLDSTPAKRENISRSSPPPLAPITQTVVAELSQVPPSPQAESPPVNFHVVAQSRKNLQQALRRARKTKQQPRLFDDEEDLEITSLQNDRNKNRTSDGKGTPPSLEPTNAAANQAAKKTIPQMSSQGMAKNNTAKSKNTCRKSSPTPTSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQPEEYGQETFLGLFELYSPEVLKKLSQRHSKRKRRTVQNASGVDFHYGQQLNAVDALVMGVRGQKKTKEKSEFLLSPTEKRLQANSKRTYTRKSKSPDEISEKSSAGGGSGASGTASSSACQHKDGGASKCRKCRECRECKRRVETEAMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPPCLREKDKLEK
Protein: DUF732 domain-containing protein (O50383)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Hypothetical proline-rich protein
- Serine protease inhibitor Rv3364c
Sequence:
MNLRRHQTLTLRLLAASAGILSAAAFAAPAQANPVDDAFIAALNNAGVNYGDPVDAKALGQSVCPILAEPGGSFNTAVASVVARAQGMSQDMAQTFTSIAISMYCPSVMADVASGNLPALPDMPGLPGS