wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q4GZA9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BRCT domain-containing protein
- Recombination initiation protein NBS1, putative
- Inositol hexakisphosphate
- Uncharacterized protein
Sequence:
MVWFSAPDNSEFLGDPLPRKARQPKVHLATEVSVEASVPWEDVSSWECGSQTSRNSSRSSTSDNAANGHVANINKFHDRMELIRRLNKRRRNNSTCRESGRTEQWTCQPLYVGVSTFPEMKEMSPKSVGGENVPFWNGAVVHDSPLMTDRSGSEVDKKPLKTRKCAWNLTYVRKNDWPEAHQMHEGDAII
Protein: Meiosis-specific serine/threonine-protein kinase mek1 (EC 2.7.11.1) (Q10292)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable protein kinase required for meiotic recombination.
Interaction partners:
- Linear element-associated protein hop1
- Homologous-pairing protein 2
- Meiotic recombination protein rec12
- Linear element protein rec10
- NURS complex subunit red1
- Meiotic recombination protein dmc1
Sequence:
MDFLSHAMLSRSESTQILCELSQIDESTMDPQYTEDDVLARLFVFSSSSPQTVLNVKKYEDVSVGRSNTCNYQLLQFTASYKHFRVYSVLIDDDMDPLVYCEDQSSNGTFLNHRLIGKGNSVLLSDGDILDVRHCASFLFQQKYTTDNDFHHEYAGERFNITQRLLGIGGFSRIYMAMDNNTGGQYACKIIDKKKISTKRFFEDHEMTILRKLDHPNIIKVNMEYNSETQFFIFEEMVTGGDLFSYLTKLGTVPEVTTLFIMFQILQGLKYLHEQNIIHRDLKLENILIASSSDTIFRIILTDFGVARCMQKGKRLSTFVGTPEYTAPEIQRLKGRSQVEKENSSGYGKEVDLWSLGVIMFLLLSGNSPSFADGVKEKQVDFRDPVWKSVSRQAKDLISNLLKTNPPDRFTVKQCLSHPWFARHSSRLTKLYETRILKPLKHSRL
Protein: Vacuolar protein sorting-associated protein 26 (F4HYH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 35A
- Paramyosin-like protein
- Coiled-coil protein
- Vesicle transport v-SNARE 13
- Uncharacterized protein
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 35C
- Sorting nexin 2B
- Sorting nexin 2A
Sequence:
MATATTVNVKLSRSNRIYRSSEPVEGKIVIKSATSISHQAIRLSVNGSVNLQVRGGSAGVIESFYGVIKPIQIVKKTIEVKSSGKIPPGTTEIPFSLNLREPGEGIVEKFYETFHGTNINIQYLLTADIPRGYLHKPLSATMEFIIESGRVDLPERPIPPEIVIFYITQDTQRHPLLPDIKTGGFRVTGKLATQCSLQDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQSTQIADGDVCRNMTLPIYVLLPRLLMCPSVFAGPFSVEFKVCITISFKSKLAKAQPKSDPTAPRLWMALERLPLELVRTKRDQFSC
Protein: AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) (Q91X58)
Organism: Mus musculus (Mouse)
Function: Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18467495}; Lipid-anchor {ECO:0000305|PubMed:18467495}.
Interaction partners:
- Acyl-coenzyme A thioesterase 8
- Abscission/NoCut checkpoint regulator
Sequence:
MEFPDLGAHCSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHCGSAYQKDIQVPVCPLCNVPVPVARGEPPDRAVGEHIDRDCRSDPAQQKRKIFTNKCERSGCRQREMMKLTCDRCGRNFCIKHRHPLDHECSGEGHQTSRAGLAAISRAQGLASTSTAPSPSRTLPSSSSPSRATPQLPTRTASPVIALQNGLSEDEALQRALELSLAEAKPQVLSSQEEDDLALAQALSASEAEYQQQQAQSRSLKPSNCSLC
Protein: Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (Q8R416)
Organism: Rattus norvegicus (Rat)
Function: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prokineticin-2
- Prokineticin-1
- Melanocortin 2 receptor accessory protein 2
Sequence:
METTVGTLGENTTNTFTDFFSARDGSGAETSPLPFTFSYGDYDMPSDEEEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFITALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQFYYRSYFLLVFGLEFVGPVIAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVTVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGIPATEEVDCIRLK
Protein: NADPH--cytochrome p450 reductase, putative (EC 1.6.2.4) (Q38D97)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Anamorsin homolog
- Homocysteine S-methyltransferase, putative
Sequence:
MFRRFCTASGILAGTCLVAFAVRVWVTRRGCLPNERSLSAKYANMLQNGQASKGCQTYQDEAILVIYGSVSGNAEMYAKTLVTNLRERGADIALIDPSAWPYLAQHTPQQPLFPASKGTQMPVVVFVVSTTGEGEVPDNFFSLFIQMKAVVRRGLEEGAEPFKDVFYAVFALGESSYKYFCRAGVDVDGLLQKGGGTELVPIGIGDARDPLRDDLFDAWEETLTKKLEETCGMKLEALSDKPPQPQLLFRFIPDKPADTLPFAPPPSLLEPSGQYPGQFVLEAKTRRTSEREDGSYVLHLVLGFGGHTVKYQAGDHLGIYPANPPDVVEAYRQVLNIPLTDWTKPVELCSPVNARARASLRNTLPARVTLRTVFERYLDLCGKPRKSMLRLLARYCSEIEEKTAMIDFLRGGHSLNAVAEFGTSTPSYRRGHYTVLDCLKMFCSWRGRLPVGHFVEAMPRMQPRFYSIASDMLTHPTTVEAFIRIIPDGVNSLFLHHLSVGAKVTAFVRKSTFHLPQKCSGRPVVMIGPGTGVASMIGFCYRREAMLKKQAAVEHGPMVLFFGNRNRSSEYFVEREVRQWCPHGEGKLPSAGVRCDSVLTLVDAAFSRDQPEKYYVTHLLEKHQDYLLKLLTSRVGGGCLIYISGDASRVSRSVDKAILKLLEYGGFAEEAAVEFLARMEREGRYLKDVY
Protein: Indian hedgehog B protein (IHHB) (EC 3.1.-.-) (Echidna hedgehog protein) (EHH) [Cleaved into: Indian hedgehog B protein N-product] (Q98862)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity).
Subcellular location: [Indian hedgehog B protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q14623}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Indian hedgehog B protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000250|UniProtKB:Q14623}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.
Interaction partners:
- Protein patched homolog 1
- Protein patched homolog 1
- Protein smoothened
- Hedgehog-interacting protein.
- BOC cell adhesion-associated, oncogene-regulated.
- Cell adhesion molecule-related/down-regulated by oncogenes
- GLI family zinc finger 2a.
- Suppressor of fused homolog.
- GLI family zinc finger 3.
- GLI family zinc finger 1
Sequence:
MRLSTAAALLTGFILAFSPAYDGCGPGRGYGKRRTPRKLTPLAYKQFSPNVAEKTLGASGRYEGKVTPSSERFKELTPNYNPDIIFKDEENTGADRMMTQRCKDKLNSLAISVMNLWPGVRLRVTEGWDEDGLHSEESLHYEGRAVDITTSDRDRNKYRMLARLAVEAGFDWVYYESKGHVHCSVKSEHSVAAKTGGCFPGRALVTMKDGSHRQIRDLQAGDLVLASEGSDGTGDLIYSEVLTFLDRRPITQKHFYVIRTEDGASVSLTAAHLLFMRVGNCSNRGEPKPGAVRTIFASDAQVGQCLLLGKLRKRFSQITHVGVREDQGLYPPLTAHGTVVVNDVLTSCYAAVNRQRLAHWAFAPLRLLYSWTGPDQVLKNGLHWYSQVLIGLGKLLLDSELFHPLALEATER
Protein: UL15 protein (Q77CB9)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MFGGAVGEQSARYFQRLLRERQRRAAERGARPDGGGGARGEDDARVPFLDFAVAAPKRHQTVVPGVGTLHGYCELAPLFAATASRLLLTSMARAEAGLNTGTGEAHVSRELAGVLSALRFAAHPPAEAAAHCNAYHSVMAALESMRASGAFAQVAAFVARFSRLVGTSFSHLGGGDDADPPRAKRARVEPPSGQTRGALELFQKMILMPATYFVAATLLGEHAERIGAFLRVAFNTPDFSDAAVAHFRQRATVFLVPRRHGKTWFLVPLIALALATFKGIKIGYTAHIRKATEPVFEEIVARLRQWFGGERVDHVKGEVISFSFPDGARSTIVFASSHNTNGIRGQDFNLLFVDEANFIRPEAVQTIVGFLNQASCKIIFVSSTNTGKASTSFLYNLKGASDGLLNVVTYICNEHTPRVAAHGGATACSCYVLNKPVFITMDAAARNTAETFLPNSFMQEIIGGGEVARRAEPAAVFTRAAGEQFLLYRPSTAAARGPWPERLYMYIDPAFTSNARASGSGIAVVGRHRGSWLVLGLEHFFLPALTGSSAAEIARCAVRCFAQVMAVHRRRLDGLFVAVEGNSSQDSAVAIALGVRRELDSLAASGAVPMPAETRFYHCRPPGSAVAYPFFLLQKQKTAAFDHFIRLFNSGRVVASQDLASLTVRLQTDPVEYLFEQLQNLTESTAGPGGARAFSGKRRGAADDLMVALVMAVFVGSLPPTDGAFCPLAPRPPAD
Protein: Granzyme K (EC 3.4.21.-) (Fragmentin-3) (Granzyme-3) (NK-tryptase-2) (NK-Tryp-2) (P49863)
Organism: Homo sapiens (Human)
Subcellular location: Secreted. Cytoplasmic granule.
Interaction partners:
- Beta-microseminoprotein
- Granzyme A
- T-cell surface glycoprotein CD3 delta chain
- Protein NKG7
- Killer cell lectin-like receptor subfamily B member 1
- T-cell surface glycoprotein CD8 alpha chain
- Eomesodermin homolog
- Perforin-1
- T-cell surface antigen CD2
- Granzyme H
Sequence:
MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNLVPPHTN
Protein: Signal transducer and activator of transcription (Q6NV46)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MAQWNQLQQLETRYLEQLYHLYSDSFPMELRQFLAPWIESQDWAYAANKESHATLVFHNLLGEIDQQYSRFLQENNVLYQHNLRRIKQHLQSKYLEKPMEIARIVARCLWEEQRLLQTATTAQQDGQVAHPTGTVVTEKQQILEHNLQDIRKRVQDMEQKMKMLENLQDDFDFNYKTLKSAGELSQDLNGNSQAAATRQKMSQLEQMLSALDQLRRQIVTEMAGLLSAMDFVQKNLTDEELADWKRRQQIACIGGPPNICLDRLETWITSLAESQLQIRQQIRKLEELQQKVSYKGDPIIQHRPALEEKIVDLFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKESGDVAAIRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRTNSDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNHPKNVNFFTKPPVGTWDQVAEVLSWQFSSTTKRGLTIEQLTTLAEKLLGPCVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSPKPPGTFLLRFSESSKEGGITFTWVEKDINGKTQIQSVEPYTKQQLNSMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPEAHPDTEFPDTGCVTQPYLKTKFICVTPTNSGNTSDLFPMSPRTLDSLMHNEAAEANPGPLESLTLDMELSSDHASPMREGFAASTVSDMDTCRNA
Protein: Cinnamyl alcohol dehydrogenase 4 (AtCAD4) (EC 1.1.1.195) (Cinnamyl alcohol dehydrogenase C) (P48523)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in lignin biosynthesis in the floral stem. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
Interaction partners:
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- Flavone 3'-O-methyltransferase 1
- Aldehyde dehydrogenase family 2 member C4
- F5F19.5 protein
- Cytochrome P450 84A1
- Phenylalanine ammonia-lyase 1
- Trans-cinnamate 4-monooxygenase
- Cytochrome P450 98A3
- Caffeoyl-CoA O-methyltransferase 1
Sequence:
MGSVEAGEKKALGWAARDPSGVLSPYSYTLRSTGADDVYIKVICCGICHTDIHQIKNDLGMSNYPMVPGHEVVGEVLEVGSDVSKFTVGDVVGVGVVVGCCGSCKPCSSELEQYCNKRIWSYNDVYTDGKPTQGGFADTMIVNQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLMASGLKGGILGLGGVGHMGVKIAKAMGHHVTVISSSDKKKEEAIEHLGADDYVVSSDPAEMQRLADSLDYIIDTVPVFHPLDPYLACLKLDGKLILMGVINTPLQFVTPLVILGRKVISGSFIGSIKETEEVLAFCKEKGLTSTIETVKIDELNIAFERLRKNDVRYRFVVDVAGSNLVEEAATTTN
Protein: Large ribosomal subunit protein uL23m (54S ribosomal protein L23, mitochondrial) (Q09727)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in mitochondrial genome encoded proteins translation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL29m
- Small ribosomal subunit protein bS18m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein uS15m
Sequence:
MSKIAGKRLVYFPNITFTLCRGLNLQPKFAVFRVPLHVNKFDVRDYLQHVYNLKVVSVKSRIYQGKLFRNQLGQVKRPQSEKRVIVEMEEPFVYPNAPNDLKDWQEGELLPDGSNVKTLSRYPKVLEQVDMKRVNEELSKLQDKQILESQQKIARLLKKKY
Protein: rRNA methylase (A0A0H2UP89)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MKRPLEMAHDFLAEVVTKEDVVVDATMGNGHDTLFLAKLAKQVYAFDIQKQALEKTQERLHQADLTNAQLILQGHETLDQFVIKAKAGIFNLGYLPAADKSVITRPQTTIEALEKLCGLLVKGGRIAIMIYYGHEGGDLERDAVLDFVIQLNQQEYTAAIYRTLNQVNNPPFLVMIEKLERYRHG
Protein: Uncharacterized protein P8B7.02 (O94252)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Localizes to the barrier septum.
Interaction partners:
- Uncharacterized protein C4H3.14c
- Myosin-51
Sequence:
MNDEESHISVLPVMNKQTSLVLQNLKEETENQLKELEKKRSQLHKEEQINLQLVYAINDLRSKTKELKAENEKEDTFLNSFNASGDLTANKKIQLREQSRKLEESLLSYHKKVKEMEKQHRSASSKLELAKLSAQQLQTNVNVLRSQNNPEILQDMISETKDCRSLIAEQLLQSASLLNDFQNDSDRIAKNHSSLIDTSRAHRVSLTNATKNYTHIFDSLLTFTRHDSEDVSTSVEKLTSKKISELEKLFADYCSIEDAFD
Protein: Acetoacetyl-CoA:acetate/butyrate CoA transferase alpha subunit (EC 2.8.3.9) (Butyrate--acetoacetate CoA-transferase subunit A) (Coat A) (P33752)
Organism: Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)
Function: Catalyzes the transfer of CoA from acetoacetyl-CoA to acetate, butyrate and propionate. Shows also low activity with valerate, isobutyrate and crotonate. Plays an important role in the metabolic shift between the acid-producing and solvent-forming states of C.acetobutylicum. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation.
Interaction partners:
Sequence:
MNSKIIRFENLRSFFKDGMTIMIGGFLNCGTPTKLIDFLVNLNIKNLTIISNDTCYPNTGIGKLISNNQVKKLIASYIGSNPDTGKKLFNNELEVELSPQGTLVERIRAGGSGLGGVLTKTGLGTLIEKGKKKISINGTEYLLELPLTADVALIKGSIVDEAGNTFYKGTTKNFNPYMAMAAKTVIVEAENLVSCEKLEKEKAMTPGVLINYIVKEPA
Protein: Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) (O89112)
Organism: Mus musculus (Mouse)
Function: Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O43813}. Cell membrane {ECO:0000250|UniProtKB:O43813}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43813}.
Interaction partners:
- Aldehyde dehydrogenase family 16 member A1
Sequence:
MAQRAFPNPYADYNKSLAENYFDSTGRLTPEFSHRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLHNVFGDPAYLQMAHSYVKQSLNCLSRRSITFLCGDAGPLAVAAVLYHKMNSEKQAEECITRLIHLNKIDPHVPNEMLYGRIGYIFALLFVNKNFGEEKIPQSHIQQICENILTSGENLSRKRNLAAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVNQGKLHSLVKPSVDFVCRLKFPSGNYPPCLDDTRDLLVHWCHGAPGVIYMLIQAYKVFKEERYLCDAQQCADVIWQYGLLKKGYGLCHGAAGNAYAFLALYNLTQDLKYLYRACKFAEWCLDYGEHGCRTADTPFSLFEGMAGTIYFLADLLVPTKAKFPAFEL
Protein: IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) (Q15051)
Organism: Homo sapiens (Human)
Function: Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21565611}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23446637}. Note=Localization to the centrosome depends on the interaction with CEP290/NPHP6.
Interaction partners:
- Centrosomal protein of 290 kDa
- X-linked retinitis pigmentosa GTPase regulator
- Calmodulin-1
- Serologically defined colon cancer antigen 8
- Nephrocystin-4
- Nephrocystin-3
- Calmodulin-like protein 3
- Nephrocystin-1
- Calmodulin-like protein 5
- Calmodulin-like protein 6
Sequence:
MKPTGTDPRILSIAAEVAKSPEQNVPVILLKLKEIINITPLGSSELKKIKQDIYCYDLIQYCLLVLSQDYSRIQGGWTTISQLTQILSHCCVGLEPGEDAEEFYNELLPSAAENFLVLGRQLQTCFINAAKAEEKDELLHFFQIVTDSLFWLLGGHVELIQNVLQSDHFLHLLQADNVQIGSAVMMMLQNILQINSGDLLRIGRKALYSILDEVIFKLFSTPSPVIRSTATKLLLLMAESHQEILILLRQSTCYKGLRRLLSKQETGTEFSQELRQLVGLLSPMVYQEVEEQKLHQAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRSKRSKMLLEINRQKEEEDLKLQLQLQRQRAMRLSRELQLSMLEIVHPGQVEKHYREMEEKSALIIQKHWRGYRERKNFHQQRQSLIEYKAAVTLQRAALKFLAKCRKKKKLFAPWRGLQELTDARRVELKKRVDDYVRRHLGSPMSDVVSRELHAQAQERLQHYFMGRALEERAQQHREALIAQISTNVEQLMKAPSLKEAEGKEPELFLSRSRPVAAKAKQAHLTTLKHIQAPWWKKLGEESGDEIDVPKDELSIELENLFIGGTKPP
Protein: Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1) (Q8N8W4)
Organism: Homo sapiens (Human)
Function: Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation (By similarity). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22246504}.
Interaction partners:
- Ultra-long-chain fatty acid omega-hydroxylase
- Magnesium transporter NIPA4
- 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
- Ceramide synthase 3
- Hydroperoxide isomerase ALOXE3
- Lipase member N
- Arachidonate 12-lipoxygenase, 12R-type
- Glucosylceramide transporter ABCA12
- Protein-glutamine gamma-glutamyltransferase K
- Short-chain dehydrogenase/reductase family 9C member 7
Sequence:
MEEQVFKGDPDTPHSISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAALAICGIEMDEYLRVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLRRLNAVYLNSSSKRVIFPRVEVYCQIELALGNECPERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPLSLSGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLSAFPAQPPVEELGQEQPQAVALLVSSKPKSAVPLVHVKETVSKPYVTESPAEDSNWVNKVFKKNKQKTSGTRKGFPRHSGSKKPSSKVQ
Protein: Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) (Q9P2G1)
Organism: Homo sapiens (Human)
Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Interaction partners:
- GATA zinc finger domain-containing protein 1
Sequence:
MGNTTTKFRKALINGDENLACQIYENNPQLKESLDPNTSYGEPYQHNTPLHYAARHGMNKILGTFLGRDGNPNKRNVHNETSMHLLCMGPQIMISEGALHPRLARPTEDDFRRADCLQMILKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDTPCDCAEKQHHKDLALNLESQMVFSRDPEAEEIEAEYAALDKREPYEGLRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWMSNPENCCQRSGVQMPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPVDMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIESVVSKEMDKRYLQFDIKAFVENNPAIKWCPTPGCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWICLEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRFKNHEHSYQLEQRLLKTAKEKMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKEIFELMQTDLEMVTEDLAQKVNRPYLRTPRHKIIKAACLVQQKRQEFLASVARGVAPADSPEAPRRSFAGGTWDWEYLGFASPEEYAEFQYRRRHRQRRRGDVHSLLSNPPDPDEPSESTLDIPEGGSSSRRPGTSVVSSASMSVLHSSSLRDYTPASRSENQDSLQALSSLDEDDPNILLAIQLSLQESGLALDEETRDFLSNEASLGAIGTSLPSRLDSVPRNTDSPRAALSSSELLELGDSLMRLGAENDPFSTDTLSSHPLSEARSDFCPSSSDPDSAGQDPNINDNLLGNIMAWFHDMNPQSIALIPPATTEISADSQLPCIKDGSEGVKDVELVLPEDSMFEDASVSEGRGTQIEENPLEENILAGEAASQAGDSGNEAANRGDGSDVSSQTPQTSSDWLEQVHLV
Protein: Protein kinase C (EC 2.7.11.13) (Q4WVG0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Protein kinase C; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator. The CWI signaling pathway regulates cell wall integrity and pyomelanin formation. CWI controls also oxidative stress response, gliotoxin production, iron adaptation and asexual development. Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection. Modulates the expression of fumiquinazoline cluster during conidiogenesis.
Interaction partners:
- non-specific serine/threonine protein kinase
- Rho GTPase Rho1
- Mitogen-activated protein kinase kinae kinase bck1
- M-phase inducer phosphatase
- Rho GTPase ModA, putative
- Rho GTPase Rho 2, putative
- Rho-associated protein kinase, putative
- Rho GTPase Rac, putative
- Rho GTPase Rho4, putative
- Rho-like small GTPase, putative
Sequence:
MDGDDLIASVYRKIEREKALITAASNMRQSTDNPLVQQRVDANIRDGRKNIAYLEEKMRELQLRQMKQEGASPTDKRLPPNPDGSAPVPPPKDYAPGYSGHEREYGDASGAYPHGGAGTMPSGAPFADPRPFAPVPKARPNYTKLDLIKYDTPYLGPKIQLMLSQLEFKLSVEKQYKAGIEKMVRLYQDEGDRKSRQDAEGRRIESNQKIQLLKQALKRYEDLHVDIESAEAPDDESLSTPNLRKPLTGLLTLRIHAVEDVDHAASSRFSRGPETFVVVKVEDAIKARTKATRTDKWQDEPFNIEIDKANEIELTVYDKSGDRPTPIGMLWVRISDIAEEMRRKKIESEFNASGWVSADKMEHGAAHGRQDAGGAPGSSNRPPSGGHSGGPGQGYAGGAPGGASAGPVLIDSWFALEPVGRIHLTLSFAKQLKDRRPFDIGLNRQGAVRQKKEEVHEKQGHKFVTQQFYNIMRCALCGDFLKYAAGMQCADCKYTCHRKCYPKVVTKCISKANYETDPDEEKINHRIPHRFEGFSNISANWCCHCGYLLPFGRKSAKRCTECGLTCHAQCTHLVPDFCGMSMEAANQILETLIRAKNHNKSASVSSGLSGRTLRPGGPPQAPQDNVALAYPQKPVEGAYGAPQRQPSAEAISAATNTYIPPQSPTAAQRQHIPPRTSSSQSPAAAAAAAAAAATGLRTPQQASDPNRPVQPPPSSHAHYDPAAYASYQQAIPPQAMQKMGAPYGMPQQQQQQAVAPMQQQVAVKEEIPPQQPKVRIGLDHFNFLAVLGKGNFGKVMLAETKSTKKLYAIKVLKKEFIIENDEVESTKSEKRVFLIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAAEVLLALKYFHENGVIYRDLKLDNILLTLDGHIKIADYGLCKENMWYGSTTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPTDAQEVMSHAFFRNINWDDIYHKRVPPPFLPTISSPTDTSNFDQEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFA
Protein: Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein) (Q8K1F9)
Organism: Mus musculus (Mouse)
Function: Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:12084582}; Single-pass membrane protein {ECO:0000305|PubMed:12084582}.
Interaction partners:
- Fibroblast growth factor 23
Sequence:
MKPVWVIILGWILLVPRVGTAWRGPPEEASFYYGTFPPGFSWGVGSSAYQTEGAWDEDGKGPSIWDAFTHGRKEQVLGGDTADTACDSYYKVQEDIALLKELQVSHYRFSLSWPRLLPTGVRAEQVNKRGIKFYSDFIDALLKSNITPVVTLHHWDLPQMLQVAYGGWQNVSMTRYFSDYADLCFEVFGDRVKHWLTFSDPRTMVEKGYETGLHAPGLRLQGTGLYVAAHHIIKAHAQAWHSYNNTWRSKQHGLVGISLNCDWGEPVDIDNPDDIEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAEQGLEMSRLPTFSLQEKSYLKGTSDFLGLGHFTTRYITQRKYPSHQGPSYQNDRDLVELVDPNWPEMGSPWLYSVPWGFRRLLNFAQTQYGDPPIYVTESGAPQKLHCTQFCDEWRIQYLKGYINEMLKAIKDGVDIKGYTSWSLLDKFEWEKGYADKYGFYYVEFNVRNKPRYPKASVQYYKEIITASGFPNPQEVESWRLKALETCSINNQMLATEPLLRHMHVASEIVVPTVCALSILTAALMLTLLLRRRG