wanglab/gogpt-training-data huggingface dataset:
Protein: Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas) (Q61140)
Organism: Mus musculus (Mouse)
Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.
Subcellular location: Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Cytoplasm {ECO:0000269|PubMed:22801373}. Cell projection, axon {ECO:0000269|PubMed:20881139}. Note=Unphosphorylated form localizes in the cytoplasm (PubMed:22801373). Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). {ECO:0000269|PubMed:22801373}.
Interaction partners:
- Paxillin
- Focal adhesion kinase 1
- Proto-oncogene tyrosine-protein kinase Src
- Adapter molecule crk
- Dedicator of cytokinesis protein 1
- Talin-1
- Vinculin
- Crk-like protein
- Talin-2
- Protein-tyrosine kinase 2-beta
Sequence:
MTVPNVLAKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPVGPGPGPPATPPQPQPSLPQGVHAPVPPASQYSPMLPTAYQPQSDNVYLVPTPSKTQQGLYQAPGPNPQFQSPPAKQTSTFSKQTPHHSFPSPATDLYQVPPGPGSPAQDIYQVPPSAGIGHDIYQVPPSLDTRGWEGTKPPAKVVVPTRVGQGYVYEAAQTEQDEYDTPRHLLAPGPQDIYDVPPVRGLLPNQYGQEVYDTPPMAVKGPNGRDPLLDVYDVPPSVEKGLLSSSHHSVYDVPPSVSKDVPDGPLLREETYDVPPAFAKPKPFDPTRHPLILAAPPPDSPAAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGSVVDDGVYAVPPPAEREAPTDGKRLSASSTGSTRSSQSASSLEVVVPGREPLELEVAVESLARLQQGVSTTVAHLLDLVGSASGPGGWRGTSEPQEPPAQDLKAAVAAVHGAVHELLEFARGAVSNATHTSDRTLHAKLSRQLQKMEDVYQTLVVHGQVLDSGRGSPGFTPEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKAPGPGPEGSSSLHPNPTDKASSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLERGNIMRQGKGQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLVPGRTGGLGPSDRQLLLFYLEQCEANLTTLTDAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVDRVKELGHSTQQFRRVLGQLAAA
Protein: Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19) (Q9NPF7)
Organism: Homo sapiens (Human)
Function: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Subcellular location: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
Interaction partners:
- Interleukin-12 subunit beta
- Interleukin-23 receptor
- Interleukin-12 receptor subunit beta-1
- Non-receptor tyrosine-protein kinase TYK2
- Tyrosine-protein kinase JAK2
- Interleukin-12 receptor subunit beta-2
- Interleukin-17F
- Interleukin-17A
- Interleukin-22
- Interleukin-6
Sequence:
MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP
Protein: Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) (P97946)
Organism: Mus musculus (Mouse)
Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.
Subcellular location: Secreted.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 3
- Vascular endothelial growth factor C
- Neuropilin-2
- Angiopoietin-1 receptor
- Neuropilin-1
- Platelet-derived growth factor C
- Receptor-type tyrosine-protein kinase FLT3
- Fibroblast growth factor receptor 1
Sequence:
MYGEWGMGNILMMFHVYLVQGFRSEHGPVKDFSFERSSRSMLERSEQQIRAASSLEELLQIAHSEDWKLWRCRLKLKSLASMDSRSASHRSTRFAATFYDTETLKVIDEEWQRTQCSPRETCVEVASELGKTTNTFFKPPCVNVFRCGGCCNEEGVMCMNTSTSYISKQLFEISVPLTSVPELVPVKIANHTGCKCLPTGPRHPYSIIRRSIQTPEEDECPHSKKLCPIDMLWDNTKCKCVLQDETPLPGTEDHSYLQEPTLCGPHMTFDEDRCECVCKAPCPGDLIQHPENCSCFECKESLESCCQKHKIFHPDTCSCEDRCPFHTRTCASRKPACGKHWRFPKETRAQGLYSQENP
Protein: Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less] (P01011)
Organism: Homo sapiens (Human)
Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Subcellular location: Secreted.
Interaction partners:
- Prostate-specific antigen
- Cathepsin G
- Chymotrypsinogen B2
- Chymotrypsinogen B
- Alpha-2-macroglobulin
- Alpha-1-acid glycoprotein 1
- Apolipoprotein E
- Albumin
- Alpha-1-acid glycoprotein 2
- Haptoglobin
Sequence:
MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA
Protein: Narrow, isoform E (A1ZAU3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKIVLFCLLSLLACAAGQRITTIHLDGVQYFISRMNPYSPELNYFLAYQYCRSLGLQLASFETKEKAESMTTYLKNAGYGNYDFWTSGNRLGTGMFLWMSTGLPFNATFDFFENSADAIQAGLLDPVDHNSNTSPQRTARDSSGAEKGCVILKQPTLKWMPEDCSAVKDFICEQTRCYYYNYGSIPVSSAQGRPITSTTPRTPASLMNLHVAATTTPLPLLMSTSGAMYTAAKAKSSPAVGHRLIDDSSSQQQPSFMSFKLNHDRSLPDTDSTDVDVEDQEADLDGEEHDDHEAEGEEEHDEHDNFEEHARELSNDNDGDIKEHVFPLSDNELHPEVHSIEEVQQQLQQEDADADSAPAPAAAEDNESSQHDAEADGEHEQDGAEGETDLENETPVDLIKANEPLAMPSSTESPAAAIEERIKQIAQDFQKMASSQELQPKEELTPQSSLSLNDLIRTLRPNEQQIIPQIDSDYSNAMRVLGKPMAANN
Protein: Poly A polymerase head domain-containing protein (Q55BE1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Strictosidine synthase family protein
Sequence:
MKILSAFQKTAKIFNNNNNNNNSYYLNKLFYSNNSIPTKNIQISPEENKLFDFLKNILIFNNRNDIELRVAGGWVRDKLLDNQKQQQPQPQPQPQQQQQIKDIDIDIDIALSNISGTNFIKLIEEFKINKESFKKYLIKRNPEKSKHLETASINIHGFQIDFNSLRNCLRRDLTINSLFYNLNTLKIEDHSGYGLSDLENSIIRTPLEPLKTLLDDPLRAFRVIRFASRFQGFQIEQQLYNTIKFNLNKQLISNKVSKERIYKEFHLMMSNKSSVIQSIDYLIDTGLINSIIDFDKIINDHEIIKELFKKSLKYLKILINQNNNNNDNLFNIDFYKCCIFLPFFIDAHLGFKDNTSKTIKSLINYQFSTNTGSTLNISLLFNNLISSFLNINNDTNNNTNNNTNNINQLKDFKLYLNNLNDKSNLYSIFHELKNCKAGGLQWNFPLNISIVYLLEKYPDRENEILDVLNQLTKLFSDDNFTFEKVSLLVDGRKIKNLFPDQSIDITNLMKSMTILQYENPNFKEDDILKWINKNIKDFILKI
Protein: C8orf58 protein (Q7Z758)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVGDSPLAALPGLSQDSLDFESSGSSEPPAQVGRLLASQKLGEVLERSRRLPTAPTSLSGQHRSLRLASKPEREVPLGAGQQESMEADTDLEAGLEEEAVGGLGPGAWACLPGQGLRYLEHLCLVLEQMARLQQLYLQLRIQRPPGDPGEEESTRAPLPSPLHTPGNRGQGPWELLSQTEHTGAKAASPPKVEVPSANPPRLPETPVEPTYHLPSSQGHKRDISHWDKVKVLLNRICRRSHHHPEPPAPPDGSDPRIESRDLPERPQCRPHRKTFMPSLVVKKQRAKKPFCRLRPLGAPGDPGWRGLAVKSSSPSALLLLLHIARKSC
Protein: ABC transporter I family member 11, chloroplastic (ABC transporter ABCI.11) (AtABCI11) (Non-intrinsic ABC protein 14) (Q8LEF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Protein TIC 21, chloroplastic
- Protein ABCI12, chloroplastic
- Protein ABCI7, chloroplastic
- Protein MITOFERRINLIKE 1, chloroplastic
- Solute carrier family 40 member 3, chloroplastic
- Ferric reduction oxidase 7, chloroplastic
- Cytochrome C assembly protein
- Iron-sulfur cluster assembly SufBD family protein ABCI8, chloroplastic
- ABC transporter I family member 19
- ABC transporter I family member 20
Sequence:
MAVSTFSSPTPVFGIAEPPASFSSTAIGWKQPLRFRRTKKPRVISCDYSCIEVRDVCYRPPGTQLNILNGVNFSLREKSFGLIFGKSGSGKTTLLQLLAGLNKPTSGSICIQGYGDDGQPKADPDLLPTEKVGIVFQFPERFFVADNVLDEITFGWPRQKGSLQLKEQLTSNLQRAFNWVGLDSIPLDKDPQLLSGGYKRRLALAIQLVQTPDLLILDEPLAGLDWKARADVAKLLKHLKKELTLLVVSHDLRELAALVDQSWRMETGGVLVAERPPL
Protein: Protocadherin-15 (Q96QU1)
Organism: Homo sapiens (Human)
Function: Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Efficient localization to the plasma membrane requires the presence of LHFPL5. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Interaction partners:
- Cadherin-23
- Unconventional myosin-VIIa
- Harmonin
- LHFPL tetraspan subfamily member 5 protein
- pre-mRNA splicing regulator USH1G
- Adhesion G-protein coupled receptor V1
- Usherin
- Whirlin
- Transmembrane channel-like protein 1
- Calcium and integrin-binding family member 2
Sequence:
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Protein: Auxin-responsive protein IAA14 (Indoleacetic acid-induced protein 14) (Protein SOLITARY ROOT) (Q38832)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 7
- Auxin response factor 19
- Auxin response factor 5
- Auxin transporter protein 1
- Protein RISC-INTERACTING CLEARING 3'-5' EXORIBONUCLEASE 1
- SKP1-like protein 1A
- Auxin response factor 8
- LOB domain-containing protein 16
- Auxin-responsive protein IAA7
Sequence:
MNLKETELCLGLPGGTETVESPAKSGVGNKRGFSETVDLKLNLQSNKQGHVDLNTNGAPKEKTFLKDPSKPPAKAQVVGWPPVRNYRKNVMANQKSGEAEEAMSSGGGTVAFVKVSMDGAPYLRKVDLKMYTSYKDLSDALAKMFSSFTMGSYGAQGMIDFMNESKVMDLLNSSEYVPSYEDKDGDWMLVGDVPWPMFVESCKRLRIMKGSEAIGLAPRAMEKFKNRS
Protein: Striatin-interacting protein 2 (Protein FAM40B) (Q9ULQ0)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21834987}. Note=Enriched in lamellipodia. {ECO:0000269|PubMed:21834987}.
Interaction partners:
- MOB-like protein phocein
- Serine/threonine-protein kinase 25
- Striatin-3
- Suppressor of IKBKE 1
- Serine/threonine-protein kinase 24
- Cortactin-binding protein 2
- Striatin-interacting protein 1
- CTTNBP2 N-terminal-like protein
- Striatin
- TRAF3-interacting JNK-activating modulator
Sequence:
MEDPAAPGTGGPPANGNGNGGGKGKQAAPKGREAFRSQRRESEGSVDCPTLEFEYGDADGHAAELSELYSYTENLEFTNNRRCFEEDFKTQVQGKEWLELEEDAQKAYIMGLLDRLEVVSRERRLKVARAVLYLAQGTFGECDSEVDVLHWSRYNCFLLYQMGTFSTFLELLHMEIDNSQACSSALRKPAVSIADSTELRVLLSVMYLMVENIRLERETDPCGWRTARETFRTELSFSMHNEEPFALLLFSMVTKFCSGLAPHFPIKKVLLLLWKVVMFTLGGFEHLQTLKVQKRAELGLPPLAEDSIQVVKSMRAASPPSYTLDLGESQLAPPPSKLRGRRGSRRQLLTKQDSLDIYNERDLFKTEEPATEEEEESAGDGERTLDGELDLLEQDPLVPPPPSQAPLSAERVAFPKGLPWAPKVRQKDIEHFLEMSRNKFIGFTLGQDTDTLVGLPRPIHESVKTLKQHKYISIADVQIKNEEELEKCPMSLGEEVVPETPCEILYQGMLYSLPQYMIALLKILLAAAPTSKAKTDSINILADVLPEEMPITVLQSMKLGIDVNRHKEIIVKSISTLLLLLLKHFKLNHIYQFEYVSQHLVFANCIPLILKFFNQNILSYITAKNSISVLDYPCCTIQDLPELTTESLEAGDNSQFCWRNLFSCINLLRLLNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMLQLYVLKLLKLQTKYLGRQWRKSNMKTMSAIYQKVRHRMNDDWAYGNDIDARPWDFQAEECTLRANIEAFNSRRYDRPQDSEFSPVDNCLQSVLGQRLDLPEDFHYSYELWLEREVFSQPICWEELLQNH
Protein: Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) (Q6YP21)
Organism: Homo sapiens (Human)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
Interaction partners:
- Aspartate aminotransferase, mitochondrial
- Kynureninase
- Kynurenine 3-monooxygenase
- Kynurenine formamidase
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Cystathionine gamma-lyase
- Aspartate aminotransferase, cytoplasmic
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- Methionine synthase
- Cystathionine beta-synthase-like protein
Sequence:
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
Protein: Metaxin-1 homolog (Mitochondrial outer membrane import complex protein 1) (O45503)
Organism: Caenorhabditis elegans
Function: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250}.
Interaction partners:
- SAM50-like protein gop-3
- Mitochondrial import receptor subunit TOM40 homolog
- Metaxin-2 homolog
- Mitochondrial import receptor subunit TOM20 homolog
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- Peroxisome biogenesis protein 3-2-like
- Mitochondrial import receptor subunit tomm-70
Sequence:
MELHIWPSDFGLPTIDVVSLQFLACSKMCASPVRVIQSTRPWRSPSGELPMVAQTEGEAKPVTDFEKFVDILKKCGQDVVIDADLTTIEKAQLDAFSCYLHHNLYPAVMHTFWTDELNYNTVTQYWYASHLHFPYNLYYLEKRRKKALRLLAGKNDTEILKEAFMALNTLSTKLGDNKFFCGNKPTSLDALVFGYLAPLLRVPLPNDRLQVQLSACPNLVRFVETVSSIYLPLGEDELKRQQANRKMWQSRISKAKADKEAAKTTEEASESLPEEPPMRDAILFTLGALTLSLVFAIHTGLIQVSVEEEISE
Protein: Cytochrome P450 89A9 (EC 1.14.14.-) (Q9SRQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the chlorophyll breakdown by its action in nonpolar primary fluorescent chlorophyll catabolite (pFCC) decarbonylation. Involved in the formation of major chlorophyll breakdown products, including non-fluorescent dioxobilin-type chlorophyll catabolites (NDCCs), during leaf senescence.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23723324, ECO:0000269|Ref.6}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- pFDCC methylesterase MES16
- Methylesterase 10
- Berberine bridge enzyme-like 8
- Protein TIC 55, chloroplastic
- At3g04640
- Pheophytinase, chloroplastic
Sequence:
MEITTIIFLIISSLTFSIFLKLIFFFSTHKLPPGPPRFPVIGNIIWLKKNNFSDFQGVLRDLASRHGPIITLHVGSKPSIWVTDRSLAHQALVQNGAVFSDRSLALPTTKVITSNQHDIHSSVYGSLWRTLRRNLTSEILQPSRVKAHAPSRKWSLEILVDLFETEQREKGHISDALDHLRHAMFYLLALMCFGEKLRKEEIREIEEAQYQMLISYTKFSVLNIFPSVTKFLLRRKWKEFLELRKSQESVILRYVNARSKETTGDVLCYVDTLLNLEIPTEEKEGGKKRKLSDSEIVSLCSEFLNAATDPTATSMQWIMAIMVKYPEIQRKVYEEMKTVFAGEEEEREEIREEDLGKLSYLKAVILECLRRHPPGHYLSYHKVTHDTVLGGFLIPRQGTINFMVGEMGRDPKIWEDPLTFKPERFLENGEACDFDMTGTREIKMMPFGAGRRMCPGYALSLLHLEYYVANLVWKFEWKCVEGEEVDLSEKQQFITMVMKNPFKANIYPRRK
Protein: Mitochondrial chaperone BCS1 (EC 3.6.1.-) (P32839)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the expression of the Rieske iron-sulfur protein.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:8599931}; Single-pass membrane protein.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Protein CBP3
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Assembly factor CBP4
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 10, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
Sequence:
MSDKPIDIQYDKQATPNLSGVITPPTNETGNDSVREKLSKLVGDAMSNNPYFAAGGGLMILGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQRVSRHLSVRTNYIQHDNGSVSTKFSLVPGPGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTSFGPEWRKFGQPKAKRMLPSVILDSGIKEGILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNNMPERSILLLEDIDAAFNKRSQTGEQGFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVGNATPYQVEKMFMKFYPGETDICKKFVNSVKELDITVSTAQLQGLFVMNKDAPHDALKMVSSLRNANHIF
Protein: Large ribosomal subunit protein uL22y (60S ribosomal protein L17-2) (P51413)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL27x
- Large ribosomal subunit protein uL23y
- Small ribosomal subunit protein eS24z
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein eL13z
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein eL31z
- Small ribosomal subunit protein eS1y
- Large ribosomal subunit protein uL4z
Sequence:
MVKYSQEPDNQTKSCKARGSDLRVHFKNTRETAHAIRKLPLIKAKRYLEDVIAHKQAIPFTRFCRGVGRTAQAKNRHSNGQGRWPAKSAQFVLDLLKNAESNAEVKGLDVDALFISHIQVNQAAKQRRRTYRAHGRINPYMSNPCHIELILSEKEEPVKKEPETQLAAKSKKSAA
Protein: LIM homeobox 4 isoform 2 (A0A0S2Z5S9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKVPGTKQ
Protein: HCG2039195, isoform CRA_a (ZNF509 protein) (Q32MK9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQRKLVKHRIRHTGERPYSCSACGKCFGGSGDLRRHVRTHTGEKPYTCEICNKCFTRSAVLRRHKKMHCKAGDESPDVLEELSQAIETSDLEKSQSSDSFSQDTSVTLMPVSVKLPVHPVENSVAEFDSHSGGSYCKLRSMIQPHGVSDQEKLSLDPGKLAKPQMQQTQPQAYAYSDVDTPAGGEPLQADGMAMIRSSLAALDNHGGDPLGSRASSTTYRNSEGQFFSSMTLWGLAMKTLQNENELDQ
Protein: Cathelicidin-1 (Bactenecin-1) (Bac1) (Cyclic dodecapeptide) (P22226)
Organism: Bos taurus (Bovine)
Function: Potent microbicidal activity; active against S.aureus and E.coli.
Subcellular location: Secreted.
Interaction partners:
Sequence:
METPRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQLNEQSSEPNIYRLLELDQPPQDDEDPDSPKRVSFRVKETVCSRTTQQPPEQCDFKENGLLKRCEGTVTLDQVRGNFDITCNNHQSIRITKQPWAPPQAARLCRIVVIRVCR
Protein: tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25) (SAM-dependent 3-amino-3-carboxypropyl transferase) (tRNA U47 acp transferase A) (tRNA aminocarboxypropyltransferase) (Q47319)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 47 of tRNAs. Acp3U47 confers thermal stability on tRNA.
Interaction partners:
- Peptidyl-lysine N-acetyltransferase PatZ
- CDP-diacylglycerol--serine O-phosphatidyltransferase PssA
- tRNA
- Uncharacterized protein YagA
Sequence:
MTENAVLQLRAERIARATRPFLARGNRVRRCQRCLLPEKLCLCSTITPAQAKSRFCLLMFDTEPMKPSNTGRLIADILPDTVAFQWSRTEPSQDLLELVQNPDYQPMVVFPASYADEQREVIFTPPAGKPPLFIMLDGTWPEARKMFRKSPYLDNLPVISVDLSRLSAYRLREAQAEGQYCTAEVAIALLDMAGDTGAAAGLGEHFTRFKTRYLAGKTQHLGSITAEQLESV
Protein: Phospholipase A2-alpha (EC 3.1.1.4) (Secretory phospholipase A2-alpha) (AtsPLA2-alpha) (Q8S8N6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Modulates the trafficking of PIN proteins to the plasma membrane. Negatively regulates MYB30 transcriptional activity and hypersensitive response control.
Subcellular location: Secreted {ECO:0000269|PubMed:20696912}. Golgi apparatus {ECO:0000269|PubMed:20525850}. Cytoplasmic vesicle {ECO:0000269|PubMed:20696912}. Nucleus {ECO:0000269|PubMed:20696912}. Note=Relocalization from cytoplasmic vesicles to nucleus is MYB30-mediated. {ECO:0000269|PubMed:20696912}.
Interaction partners:
- Lecithin-cholesterol acyltransferase-like 4
- Lysophospholipid acyltransferase 1
- Phospholipase A
- Triacylglycerol lipase SDP1
- Lipoxygenase 6, chloroplastic
- Lipoxygenase 3, chloroplastic
- Lipoxygenase 4, chloroplastic
- Lipoxygenase 2, chloroplastic
- Non-specific phospholipase C1
- Non-specific phospholipase C5
Sequence:
MAAPIILFSFLLFFSVSVSALNVGVQLIHPSISLTKECSRKCESEFCSVPPFLRYGKYCGLLYSGCPGERPCDGLDSCCMKHDACVQSKNNDYLSQECSQKFINCMNNFSQKKQPTFKGNKCDADEVIDVISIVMEAALIAGKVLKKP
Protein: GM13546p (Q8MZ50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEIDLGFAEKSDNGAWLSNRYFPSKLGGQPAWLELEALPPTSQLQCSKCRAPKSFLAQLYAPFEDEYNFHRSIYVFLCRNSDCQEAQNASNFTVLRSQLPRKNKFFSEEEPSDVGQPLPAVPCLKKLCAACGCHAPHACSKCKAIHYCSSEHQRAHWPQHKPNCGAPEVATEKPLTQIVFPEFEIVMDSNPVESGEEDKDDEARLAEFQELESSGKTGDLSNVSEAEMDKYFGNSAAADDKTFRQFKKQTAAEPDQIVRYKRGGQPLWITNTVKTVEDQLNKLPNCIACGGERQFEFQIMPQALTLLEDENLDWGVLAVYTCAKSCPIDGYVEELLIKQDIVAEDQS
Protein: Eukaryotic translation initiation factor 4B, isoform E (Q7PLL1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASAGKKGKKNKGTVISLQSFLCNSDAPVGTTQVSKKIRNLDGDDSDDGSGTLPLVYQLPTAPRANRIFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPREDGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNGDNRDSGNWRRDSQNNGSNFGYSSNFERSFNRERKSLPDRDDVNTPGSWRTSARPQSIDTSPTRREVEQVSEKYREGRVKIADRYSREETSKVEEERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTSSLNVFGSAKPVDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKNDNESLSATVSWRTNQDYKESDKINKCPA