wanglab/gogpt-training-data huggingface dataset:
Protein: Thioester-containing protein 4, isoform C (M9PDR0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRRADAFAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKLCDICEGDDCKSKC
Protein: UBE2W protein (Q96FI0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASMQKRLQKELLALQNDPSPGMTLNEKSAQNSITQWIVDMESAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHELKSAFILSITD
Protein: Luminal-binding protein 2 (BiP 2) (Q8T869)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Luminal-binding protein 1
- Endoplasmin homolog
- J domain-containing protein
- J domain-containing protein
- Calnexin
- Nucleotide exchange factor Fes1 domain-containing protein
- Calreticulin
- 60 kDa heat shock protein, mitochondrial
- Probable derlin-1 homolog
- Probable derlin-2 homolog
Sequence:
MNKSIYALLCLLLLISFAAAAEKKEEEKKDYGSVIGIDLGTTYSCVGVFKKGKVEIIPNDQGNRITPSYVAFTETERLIGEAAKNQATLNPENTIFDIKRLIGRRFDDEEVQRDMKLLPYKIVSKNNKPYVVVKVKGEEKTYSPEEISAMILGRMKEIAEASLGKTVTHAVVTCPAYFNDAQRAATKDAGVIAGLEVLRVINEPTAAALAYGFDATGDKEKNILVYDLGGGTFDVSVLSIEDGVFEVRSTNGDTHLGGEDFDQRVMKHFLTVFQKKTGKDASKDKKSLQKLRRAAENAKRILSTSPQTQLEIENFFDGKDLIETLTRAKFEELNMDLFKKTLDPVKKVLEDAKFKKSQIHEVVLVGGSTRIPKIQQLLKDFFNGKEPNRGVHPDEAVAYGAAVQGGIFTNEEGTDTLVLLDIAPLTLGIETVGGVMTALIPRGTFVPTKKSQVFSTYQDNQDRVSIQIYEGERSMTKDNNLLGKFDLSGIPPAQRGVPQIEVTFEMDVNGILHVSAEDKASGSKESITITNDKERLSQADIDRMVKEAADAADEDKAAKERVEAKNTLENYIYQIKNTIGDKDKIGGKIESDDKETIETAISDALSWLDVNSSAEKEEFDEQYKILEKIVQPIFSKLYGAAGGSPNGAGEDMPNHDEL
Protein: Transcription factor atf-2 (cAMP-dependent transcription factor atf-2) (Q21361)
Organism: Caenorhabditis elegans
Function: Acts as a transcription factor that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many promoters. Involved in the development of the excretory duct cell, by positively modulating embryonic transcription of putative transcription factor lin-48, acting in concert with cell death specification protein ces-2. Negatively modulates expression of key autophagy-related genes, bec-1/ATG6 and lgg-1/ATG8, and may link together autophagy and apoptosis during development. Positively modulates expression of neuropeptide pigment dispersing factor homologs pdf-1 and pdf-2.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor atf-7
- Transcription factor ces-2
- Cytochrome c oxidase subunit 5A, mitochondrial
- COX5B-domain-containing protein
- Mitogen-activated protein kinase pmk-1
Sequence:
MDVDSASLSPSSRLSVVCSASAEFSSSSSDSSNFSEGSPPESRRNSVNESVIKDEHYWERRRRNNDASRRSREKRRQNDLAMEEKIMLLSAENERLKSQLGTTPIPQPSVTEPPTSLIIPQVAKNLFPAGPIASLQASSMLTVPLLQAASHIPSMLQLCQLQPTTIQSPVYASTQQPASTSASSLFSSSSSSAFHPFRPSESAQQSFPSSSVIVKIERRSPDSSTDVNMPQPQLQPGSSVIQQIGQPAPSGTPQPVIQAVQQGPSLLSALLSQRRPSPTVPQSRTEHISGLNSPPRHTGNKSDCESVSSSASFSPSHSSEDHSNYSNKSPQYVDRRRRNNEAAKRCRANRRAVFEYRSRRVQLLEGENEDLRTQIETLKAEIAHFKSVLAQRASVVTALHP
Protein: Potassium channel subfamily K member (A5PLK0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}. Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
Interaction partners:
Sequence:
MLQCLSGSSCMRVIDGYKSTWYFLVLVLAYVLYLIFGALVFSAVELPYEEQLRQELRTVKQQFLEDNECLSNDRLEEFLIKALEASNYGVSVLNNASSNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVVGIPFTLLFLTAVVQRIMEFSTRRPIEFLHRRWGTSKPLLAAMHATLLAIITVSCFFLIPAIIFSVLEEEWNFLESFYFCFISLSTIGLGDYVPGEGYHQRFRELYKLGITFYLILGLIAMLVVLETFCELQQLKKLRKMFYLRKQKTEDQLNIVDHDHLSFASVSDQAASFREDKTELFPDDIVSGSPTATSNGSLER
Protein: Association with the SNF1 complex (ASC) domain-containing protein (Q57XE4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- CBS domain-containing protein
- Serine/threonine protein kinase, putative
- phosphatidylinositol 3-kinase
- Atg6 BARA domain-containing protein
- Protein kinase, putative
- Protein kinase, putative
- Small GTPase, putative
- Uncharacterized protein
- SET domain-containing protein
- Ras-family member, GTP-binding protein, putative
Sequence:
MGQHSAKEFRGSRRGESNSGVFPLGPGHAHVGMGSTKKPLGIHTSAVQNNVLRQRNQHRRVMHEEGGSHPRGQEADGSHGEDIAEEKFPVVIRYAAHDVRSLLSSNEKVYVAVESLNWSKLPMTASEDSFYAIVELPQGPQRFRFVVGETEVVDTAQPIEDIAEGTPLLEPRGDVGHKGETRANVIHVNKALLLTKEDEEVPDDGSGWGQEEIIHKEDRKHPPIMPVHLRYTPVNTPLTAARCALDGFMRTTDEDTVSPENLPIPLSVTVNHVYFQRREDHCVTAMTTRFCNKYSTMVYYSKAEPTASLQ
Protein: Dof protein (O96757)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLKVENIEMETFCCDNCGNVNNTSGSSASGFLGSPGYNMDDILIITAKHSERAYLRATFLKNHFDKITKQRGRKPFNFLHIKIDDGPFSEEIAHKYQNTALQIVILCPALLALPHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALPSYYKWRRCVVRDNDQVQISNILGIATDILGRALCQRPPCQDSSGGGGGGLSRSFSSCTEGFTVLPKKVKLGQNKVVALLAEPLEKNDTLKLLVEKSGELIELRNFKCRNPYTLQFNIPEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPVERDALDQHLLQCFQRNMPPNFHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQLMECPGGDTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHELTTMYHYFKGVTPPGESCPKPSANVVIEAHPGKAGKTNKPPKELPTAEYMEMSSGSERENTPEVRTKTETLAISNLNYISVETEDENLQASVAEKKVESEKKLPEAGNQPGPEKTTNELRINEPPYYQSKEQNQQPKELKNQSKSLDEVDAAPLYQTDKFSQECSQLLENQLGNDYVLQPSNVPVAQDDGNYLFQPSNRPVEEPLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDELAEIMHDFKNNVLSIRDVEVLVERWKHRNDVQQSFREKQDQIDQLRREYERIQEQVKSHLKRETPFERIKKFFLRSKTPGGNDSLLDETKSSIATSCSFKSAGGVSSSAGAGRPISSLSLQSVSSSSSSSGRLSTGSNCSGASLGDSGTHSDHEDRRFQHCRMMDNYMVPPTPRPVFTPSSTPGDERHQIVFPSPMSSCQRLNTPTSPTGSEHYQMFPSNIPVYGSQPLVGSQSSNYLNTIMEAKEQAETQHYQNQNGVTLQPIKLNERSNIIYGKLTKSSSASGCSSFKPKQIPVPCPQVGSIEVQAEVYQNVGDVAPEKDSKAEEETPNYMNC
Protein: ATPase H+-transporting V0 subunit b (V-type proton ATPase 21 kDa proteolipid subunit) (F1QYM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029431}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00029431}.
Interaction partners:
- V-type proton ATPase subunit d 1
- V-type proton ATPase proteolipid subunit
- Vacuolar proton pump subunit B
- V-type proton ATPase proteolipid subunit
- V-type proton ATPase subunit D
- V-type proton ATPase subunit H
- H
- V-type proton ATPase subunit F
- ATPase H+-transporting accessory protein 1b
- Vacuolar proton pump subunit B
Sequence:
MMNGHAILYTGVTLAFWSTMVIVGICYTIFDLGFRFDVAWFLTETSPFMWANLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNLAENFSGTTPETIGSKNYQAGYSMFGAGLTVGFSNLFCGICVGIVGSGAALADAQNANLFVRILIVEIFGSAIGLFGVIVAILQTSKVKMGN
Protein: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A) (Q9D1T0)
Organism: Mus musculus (Mouse)
Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18186492}; Single-pass type I membrane protein {ECO:0000269|PubMed:18186492}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 16
- Reticulon-4
- Tumor necrosis factor receptor superfamily member 19
- Reticulon-4 receptor
- Myelin-associated glycoprotein
- Transforming protein RhoA
- Oligodendrocyte-myelin glycoprotein
- Myocilin
- Paired immunoglobulin-like receptor B
Sequence:
MLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI
Protein: Large ribosomal subunit protein mL41 (54S ribosomal protein L27, mitochondrial) (YmL27) (P36526)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL30m
- Small ribosomal subunit protein uS12m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL34m
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein mL43
Sequence:
MKGSPISQFSKTSINALTRPWKKYRDGELFYGLSKVGNKRVPLTTKQGNKTMYKGTRASGIGRHTKFGGYVINWKKVRTYVTPDMVNFELKPYVNANVPPLKHEFKGFSGGPLDPRLQLLKIKEYIVNGRVQSEGATDTSCYKERG
Protein: Intron-encoded DNA endonuclease aI5 beta (EC 3.1.-.-) (Q9ZZX0)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial DNA endonuclease involved in intron homing.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Cytochrome b mRNA maturase bI2
- Cytochrome b mRNA maturase bI3
- Intron-encoded DNA endonuclease aI5 alpha
- Intron-encoded RNA maturase bI4
- Cytochrome c oxidase subunit 3
- Putative COX1/OXI3 intron 1 protein
- Putative COX1/OXI3 intron 2 protein
- Cytochrome c oxidase subunit 2
- Cytochrome b
- Cytochrome c oxidase subunit 1
Sequence:
MLMLLMMILTNNKVFMETLYYYLMFNFQLMSPFGVPVPGPAPETKDIKNLYESIMNNYINILNKYTININKDNINKLKFLDNYTEEEKGYYLSGLFEGDGNIYTRCFSITFSLEDVLLANYLCTYFKIGHITAKYNFNKELTAVKWNIMKKKEQEVFMNYINGKLLTYKRYDQYFKYNFNNRLNIKLLKPKEFDLTLNPWLTGFNDADGYFYTGFQKHKNSQWLKFHLELSQKDSYILDIIKKYFKTGGILKRDYKSGATAYIYKAQSSKAMKPFIEYFNNYQPLSTRRYKQYLLLNIAYLLKLNKLHMLTNSLLMLKELMLLQSVKNMSLEMKNELNNRVKIIINKTHYNNIE
Protein: Ribosome quality control complex subunit NEMF homolog (Protein Caliban) (Q9VBX1)
Organism: Drosophila melanogaster (Fruit fly)
Function: As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (By similarity). Responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Binds to Ala- and Thr-tRNAs and, to a lesser extent, Ser-tRNA. On mitochondrial surface, plays a role in mitochondrial-stress induced translational termination impairment and protein carboxyl terminal extension (MISTERMINATE). Important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. Plays a role in the regulation of G1-to-S cell cycle transition. Regulates S phase checkpoint by antagonizing E2F1 activity. Together with hid and tefu/ATM, plays a role in DNA damage-induced apoptosis through both p53-dependent and -independent activity. Plays an essential role in the regulation of mitochondrial structure and redox state in enterocytes which is essential for the control of intestinal stem cells proliferation and intestinal homeostasis.
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:33057338}. Mitochondrion outer membrane {ECO:0000269|PubMed:33057338}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase listerin
- BcDNA.GH11023
- Large ribosomal subunit protein uL5
- Protein pelota
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL18
- FI01658p
- Large ribosomal subunit protein uL29
- RING-type E3 ubiquitin transferase
- Large ribosomal subunit protein uL13m
Sequence:
MKTRFNTFDIICGVAELQKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRFEWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYELTTLYILRPHTEGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDCGPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQELIAEGNSGKSKGYIIQVKEEKPTENGTVEFFFRNIEFHPYLFIQFKNFEKATFESFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQSLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPYDNDEDDDLKDPEVTVVDVDLALSAWANARRYYDMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQEVPPVSSEPKNPSQVKRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDELLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNIPGKVKLSAPQLQKYHK
Protein: Type IV secretion system protein virB5 (Q2YJ75)
Organism: Brucella abortus (strain 2308)
Function: The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.
Interaction partners:
- Type IV secretion system protein virB2
- Type IV secretion system protein VirB6
- Type IV secretion system protein virB4
- Type IV secretion system protein virB3
- Type IV secretion system protein virB9
- Type IV secretion system protein virB10
- Type IV secretion system protein virB8
- Type IV secretion system putative lipoprotein virB7
- Type IV secretion system protein VirB11
Sequence:
MKKIILSFAFALTVTSTAHAQLPVTDAGSIAQNLANHLEQMVKFAQQIEQLKQQFEQQKMQFDALTGNRGLGDILRDPTLRSYLPHNWRDLYEAVMSGGYLAAAGETANLLRKSQVYDPCASISDKDQRIACEAKVVKPVQDKVMTSKAYDATDKRLQEIESLMQEINKTGDPKAIAELQGRIESENAMIQNEDTRLRLYQQMAEAQDKLLDERQHELDAKDNARRGYPQPKALEAAY
Protein: lipopolysaccharide heptosyltransferase II (EC 2.4.99.24) (G3XD35)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- UDP-glucose:
- Lipopolysaccharide core heptose
- Lipopolysaccharide heptosyltransferase 1
- 3-deoxy-D-manno-octulosonic acid transferase
- Serine/threonine protein kinase
- Lipopolysaccharide kinase
- Bifunctional protein HldE
- Heptose kinase
- Phosphoheptose isomerase
- D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
Sequence:
MRILIVGPSWVGDMVMAQTLFQCLRQRHPECVIDVLAPEWSRPILERMPEVRQALSFPLGHGVMDVATRRRIGRGLRGQYEQAILLPNSLKSALVPWFAGIPKRTGWRGEMRYGLLNDIRKLDKQRYPLMIERFMALAFEPGVELPKPYPQPRLRIDDGSRQAALDKFALSLDRPVLALCPGAEFGEAKRWPAEHYAAVAEAKIRAGWQVWLFGSKNDHPGGEEIRQRLIPGLREESFNLAGETSLAEAIDLMSCAGAVVSNDSGLMHVAAALDRPLVGVYGSTSPQFTPPLADRVEIVRLGLECSPCFERTCRFGHYNCLRELPPGLVLQALERLVGDPAEVAG
Protein: Repulsive guidance molecule A (RGM domain family member A) (Q6PCX7)
Organism: Mus musculus (Mouse)
Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Neogenin
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-1
- Repulsive guidance molecule B
- Bone morphogenetic protein 2
- Growth/differentiation factor 5
- Netrin-1
- Netrin receptor UNC5B
Sequence:
MQPPRERLVVTGRAGWMGMGRGAGRSALGLWPTLAFLLCSFPAAISPCKILKCNSEFWSATSSGSHAPASDDVPEFCAALRTYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDGPTSQPRVRTLPPAGDSQERSDSPEICHYEKSFHKHSAAPNYTHCGLFGDPHLRTFTDHFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPSAFADGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDRDSQGLYLCLRGCPLNQQIDFQAFRANAESPRRPAAASPSPVVPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDGKMLHSNKDKLHLFERTRELPGAVAAAAAAATTFPLAPQILLGTIPLLVLLPVLW
Protein: DNA repair protein rhp54 (EC 3.6.4.12) (RAD54 homolog 1) (P41410)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.
Subcellular location: Nucleus.
Interaction partners:
- DNA repair protein rhp51
- DNA repair and recombination protein rad22
- DNA repair protein rhp55
- DNA repair protein rhp57
- Crossover junction endonuclease mus81
- ATP-dependent DNA helicase srs2
- Meiotic recombination protein rdh54
- DNA topoisomerase 3
- Exodeoxyribonuclease 1
- Protein VAC14 homolog
Sequence:
MIQQPTTAKPRISTSSKLNTVLSKNKENVPGKLFKKFKCPSLVISEKRKELPLRKKPRVNYSEYGSVDGKYDSAYVSENVSGLATIKEANRLILNHERRDPSTVIKKQFSVPKPIKGHEDISKLCAHRPPPTLGMKRKVDFIPRPLYDPADEFAIVLYDPTTDADEIIPDIKEVLAEKRKKDELLKNRKGKKEISDSEPESDHDSCVSTDTVASCSTEQSLITSNTSKHRRPNKSLKDLLGIQKEKPPPPPVAVVIDPKLARILRPHQIEGVKFLYKCVTGRIDRCANGCIMADEMGLGKTLQCIALLWTLLKQSPQAGKPTIEKAIITCPSSLVKNWANELVKWLGKDAITPFILDGKSSKQELIMALQQWASVHGRQVTRPVLIASYETLRSYVEHLNNAEIGMLLCDEGHRLKNSDSLTFTALDKLNVQRRVILSGTPIQNDLSEYFSLLNFANPGLLGSRQEFRKNYEIPILKGRDADGTEKDKENGDAKLAELAKIVNRFIIRRTNDILSKYLPVKYEHVVFCNLSEFQLSLYKHFITSPEINKILRGTGSQPLKAIGLLKKICNHPDLLNLTEDLEGCEALFPPGFIPRELRGRDRNIDSSLSGKMLVLERMLYQIKQETDDKIVLISNYTSTLDLFEQLCRARGYKALRLDGTMNVNKRQRLVDTFNDPEKDAFVFLLSSKAGGCGINLIGANRLILFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSSCVVDEAQDVERHFSLDNLRQLFQLNDHTVCETHETYKCKRCRDGKQFIRAPAMLYGDTSTWNHFTNPTLDRIEDHLLKREAGKQQVSTVFQYKSH
Protein: Signal peptidase I (EC 3.4.21.89) (Q9I441)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU362042}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362042}.
Interaction partners:
- Signal peptidase I
- Lipoprotein signal peptidase
- Protein translocase subunit SecY
- Protein translocase subunit SecF
Sequence:
MGLLAAIMLAVYLANPFGTASLDPRARLLGVALYKIPSRSMEPTLQQGDFILANAARYAFADPQVGDLVVFRFPPQRSIAYVKRIAGIPGDRVRIDGGRLYVNERPVTEPYLAQQALRQPESLRMAERTVPAGQYFMLGDNRDNSNDSRYWGYVPRADLVGRVFAVWYAEDTRRIGSVR
Protein: At1g31760 (SWIB/MDM2 domain superfamily protein) (Q9C504)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alpha/beta-Hydrolases superfamily protein
- Protein DETOXIFICATION 37
- Protein DETOXIFICATION 49
- Serine/threonine-protein kinase BSK6
- Eukaryotic translation initiation factor isoform 4G-2
- Uncharacterized protein At5g08430
- Phototropic-responsive NPH3 family protein NPY5
- Chromatin structure-remodeling complex protein BSH
- Chaperone DnaJ-domain superfamily protein
- Single-stranded DNA-binding protein WHY2, mitochondrial
Sequence:
MAGISRVLGGFRTLMSKAATVEAVTVAGEGKGIFKTRPVSQQLASFAGERELTRGSALKKVWEYVKLHNLQNPANKKEIHCDDKLKTIFDGKDKVGITEIMKLLSPHFPKSV
Protein: Disks large homolog 5 N-terminal domain-containing protein (Q9D3W2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MWMALRQASSPVPVISKKQFEKEEKKLIKEIQLTTKETNELRDRLIYVTEESMNKRPYHRQNPLYEKLKLKEKEIMTFLHNLEMENMEAQENKQELKKETHFYRNLHSRLLMEENLIKKKLMTLQQESKEVQADWAIIHQCLVELNLSGKDEQEENSNLETPEYQVSETARELGLATAEEDSILQNELPGQEAPAEHHLQHLQSSSDESSSI
Protein: GTP-binding protein GTR1 (EC 3.6.5.-) (Q00582)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. Also required for TORC1 inactivation during nitrogen starvation. Required for intracellular sorting of GAP1 out of the endosome. Functionally associated with the inorganic phosphate transporter PHO84, and may be involved in regulating its function or localization.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:28993463}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Protein SLM4
- GTP-binding protein GTR2
- Protein MEH1
- Target of rapamycin complex 1 subunit KOG1
- Protein EGO2
- Nitrogen permease regulator 2
- Serine/threonine-protein kinase TOR1
- Nitrogen permease regulator 3
- Serine/threonine-protein kinase TOR2
- Protein LTV1
Sequence:
MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLWDCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDIEIFAKALKQLRKYSPDAKIFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLIGFPTSIWDESLYKAWSQIVCSLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICSSNGENSNENHDSSDNNNVLLDPKRFEKISNIMKNFKQSCTKLKSGFKTLILNNNIYVSELSSNMVCFIVLKDMNIPQELVLENIKKAKEFFQ