wanglab/gogpt-training-data huggingface dataset:
Protein: Regulation of nuclear pre-mRNA domain-containing protein 2 (Q5VT52)
Organism: Homo sapiens (Human)
Interaction partners:
- Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
- Regulation of nuclear pre-mRNA domain-containing protein 1B
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB2
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB1
- SR-related and CTD-associated factor 8
- Pre-mRNA cleavage complex 2 protein Pcf11
- Regulation of nuclear pre-mRNA domain-containing protein 1A
- 5'-3' exoribonuclease 2
Sequence:
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYPHRLNLFYLANDVIQNCKRKNAIIFRESFADVLPEAAALVKDPSVSKSVERIFKIWEDRNVYPEEMIVALREALSTTFKTQKQLKENLNKQPNKQWKKSQTSTNPKAALKSKIVAEFRSQALIEELLLYKRSEDQIELKEKQLSTMRVDVCSTETLKCLKDKTGGKKFSKEFEEASSKLEEFVNGLDKQVKNGPSLTEALENAGIFYEAQYKEVKVVANAYKTFANRVNNLKKKLDQLKSTLPDPEESPVPSPSMDAPSPTGSESPFQGMGGEESQSPTMESEKSATPEPVTDNRDVEDMELSDVEDDGSKIIVEDRKEKPAEKSAVSTSVPTKPTENISKASSCTPVPVTMTATPPLPKPVNTSLSPSPALALPNLANVDLAKISSILSSLTSVMKNTGVSPASRPSPGTPTSPSNLTSGLKTPAPATTTSHNPLANILSKVEITPESILSALSKTQTQSAPALQGLSSLLQSVTGNPVPASEAASQSTSASPANTTVSTIKGRNLPSSAQPFIPKSFNYSPNSSTSEVSSTSASKASIGQSPGLPSTTFKLPSNSLGFTATHNTSPAAPPTEVTICQSSEVSKPKLESESTSPSLEMKIHNFLKGNPGFSGLNLNIPILSSLGSSAPSESHPSDFQRGPTSTSIDNIDGTPVRDERSGTPTQDEMMDKPTSSSVDTMSLLSKIISPGSSTPSSTRSPPPGRDESYPRELSNSVSTYRPFGLGSESPYKQPSDGMERPSSLMDSSQEKFYPDTSFQEDEDYRDFEYSGPPPSAMMNLEKKPAKSILKSSKLSDTTEYQPILSSYSHRAQEFGVKSAFPPSVRALLDSSENCDRLSSSPGLFGAFSVRGNEPGSDRSPSPSKNDSFFTPDSNHNSLSQSTTGHLSLPQKQYPDSPHPVPHRSLFSPQNTLAAPTGHPPTSGVEKVLASTISTTSTIEFKNMLKNASRKPSDDKHFGQAPSKGTPSDGVSLSNLTQPSLTATDQQQQEEHYRIETRVSSSCLDLPDSTEEKGAPIETLGYHSASNRRMSGEPIQTVESIRVPGKGNRGHGREASRVGWFDLSTSGSSFDNGPSSASELASLGGGGSGGLTGFKTAPYKERAPQFQESVGSFRSNSFNSTFEHHLPPSPLEHGTPFQREPVGPSSAPPVPPKDHGGIFSRDAPTHLPSVDLSNPFTKEAALAHAAPPPPPGEHSGIPFPTPPPPPPPGEHSSSGGSGVPFSTPPPPPPPVDHSGVVPFPAPPLAEHGVAGAVAVFPKDHSSLLQGTLAEHFGVLPGPRDHGGPTQRDLNGPGLSRVRESLTLPSHSLEHLGPPHGGGGGGGSNSSSGPPLGPSHRDTISRSGIILRSPRPDFRPREPFLSRDPFHSLKRPRPPFARGPPFFAPKRPFFPPRY
Protein: Hairy-related 4, tandem duplicate 4 (B0V3D3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Si:ch211-188p14.2.
- mRNA decay activator protein ZFP36
Sequence:
MTPTITGSISSRETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFVKQQPDSRQEKADILEMTLDFLRRSQKSSAAGDGRSRCVQEAVSFLSQCPVQTQSHTRLMKLFLHMQTPADQHTRVDNPQTTEKHANSSAKQHTPARSHIWRPW
Protein: Phosphoglycerate kinase (EC 2.7.2.3) (P51903)
Organism: Gallus gallus (Chicken)
Function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Phosphoglycerate mutase 1
- Glucose-6-phosphate isomerase
- Phosphoglycerate mutase
- Alpha-enolase
- Cleavage stimulation factor subunit 3
- Gamma-enolase
- Gp_dh_C domain-containing protein.
- Pyruvate kinase PKM
Sequence:
MSLSNKLTLDKVDVKGKRVVMRVDFNVPMKDHKITNNQRIKAAVPTIKHCLDHGAKSVVLMSHLGRPDGVPMPDKFSFSPVAVELKALLGREVSFLKDCVGPEVEKACANPANGSVILLENLRFHVEEEGKGKDASGNKIKADAAKVEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVHLPQKAAGFLMKKELDYFAKALESPERPFLAILGGAKVQDKIQLISNMLDKVNEMIIGGGMAFTFLKVLNNMQIGNSLFDEEGSKIVKDLMAKAEKNGVKITLPVDFITADKFDEHAQTGEATVASGIPAGWMGLDCGPESVKKFVEVVGRAKQIVWNGPVGVFEWDKFSKGTKALMDKVVEVTGKGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSSV
Protein: P-type phospholipid transporter (EC 7.6.2.1) (F7FKA8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MELEEDLNGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNATDIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKENTRKSCAYGRALHSKINDKQNKRNQFCCHVYLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
Protein: Magnesium transporter MRS2-10 (Magnesium Transporter 1) (AtMGT1) (Q9SAH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity magnesium transporter that mediates the influx of magnesium. Involved in tolerance to Aluminum.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11752386}; Multi-pass membrane protein {ECO:0000269|PubMed:11752386}.
Interaction partners:
- Protein ALUMINUM SENSITIVE 3
- Magnesium/proton exchanger
- Protein DETOXIFICATION 42
- Aluminum-activated malate transporter 1
- Protein SLOW WALKER 2
Sequence:
MSELKERLLPPRPASAINLRGDAGSRPSPSGRQPLLGVDVLGLKKRGQGLKSWIRVDTSANSQVIEVDKFTMMRRCDLPARDLRLLDPLFVYPSTILGREKAIVVNLEQIRCIITADEVLLLNSLDNYVLRYVVELQQRLKASSVTEVWNQDSLELSRRRSRSLDNVLQNSSPDYLPFEFRALEVALEAACTFLDSQASELEIEAYPLLDELTSKISTLNLERARRLKSRLVALTRRVQKVRDEIEQLMDDDGDMAEMYLTEKKKRMEGSLYGDQSLPVYRTNDCFSLSAPVSPVSSPPESRRLEKSLSIVRSRHDSARSSEDATENIEELEMLLEAYFVVIDSTLNKLTSLKEYIDDTEDFINIQLDNVRNQLIQFELLLTTATFVVAIFGVVAGIFGMNFEIDFFEKPGAFKWVLAITGVCGLVVFLAFLWYYKRRRLMPL
Protein: SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (Q9JL10)
Organism: Mus musculus (Mouse)
Function: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
Interaction partners:
Sequence:
MLSKGLKRKREEEETMEALSVDSCWLDPSHPAVAQTPPTVASSSLFDLSVVKLHHSLRQSEPDLRHLVLVVNTLRRIQASMEPAPVLPPEPIQPPAPSVADSLLASSDAGLSASMASLLEDLNHIEDLNQAPQPQADEGPPGRSIGGISPNLGALDLLGPATGCLLDDGLEGLFEDIDTSMYDSELWLPASEGLKPGPENGPAKEEPPELDEAELDYLMDVLVGTQALERPPGPGR
Protein: Possible oxidoreductase (P96816)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- SnoaL-like domain-containing protein
- Peptide methionine sulfoxide reductase MsrA
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS12
- Precorrin-8X methylmutase
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS3
- Conserved protein
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS8
Sequence:
MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARALILAAERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS
Protein: Uncharacterized protein C16E8.18 (O13746)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MEVTSFILNATFKEFACFGNNYLIILPGIMLERNVFRHLNYSTNSICSHYQFFGGHYESFELLVVIVYYFSHVGSFSLAEIYRITWDKRIVLYGTTTTLVYCSEGSD
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q57X41)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRLQLQQLINYLMLAVAALYLQSSLACANKPAKGTEANTNIKNPCQEKKFNDKLIQIYEASLAGARRTLAELASDSRKIKLALCKEQDANRASALTLLETLTDYSLRKANMELTTKSAAVTAAVTVLNKRNAHLLTLMGIKPGEVTYPDAAETADATTEMSASSRSCTVKPKFAPTTGEACPVENGNYDSQETAAAKLVTLRSYTPIADAEFAAHQLTVKIGGKGDVNSGNAPLTTKDGCSSSAGHNKGNIDTGMIILGISPTKSTYTTQTTYLVGGDKETEECAAEEEPETKYFVTAKHLAYTLCRIRNNLPKMPERPLTKKIKALRAEADVQQLAYLALNGKPTKETTTKQKEEEAEKLLGTEDKTAEAKFVEPYNSQKFDFESTATDGGKSLTDLVDGDDYGLGLAICHYEATKKAIATTKTTPKGDGKTDSADKTEEKKDGDNKTTAAECKATEEGKCDKTKCTWNAEKKQFKVKEGAAVISAVIKAPLLLAFLLI
Protein: T. brucei spp.-specific protein (Q38ET4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTLEGGISDWEVIDESEESFDETAGKQTNDRCANVVVVGYGNNDCDDDENTGKLLSSTDSFSLAGTPRERSNLKDEEETRRQRNAVRMADLNTNATTEVDNETHDELAEIKELCAVQQEQLKRQAEEIRELKERLNERAMHSEERTRIIEAQSKRIGCLLRVVERLKSRESSKVFYQDEENAELQMGLEHLKVGTNNSHHHAPMFNTAPPQRRALIFECRKQPSDWETPIGEGA
Protein: Elongator complex protein 3 (EC 2.3.1.311) (tRNA uridine(34) acetyltransferase) (Q5RIC0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Involved in somite development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H9T3}. Nucleus {ECO:0000250|UniProtKB:Q9H9T3}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 4
- Elongator complex protein 5
- Elongator complex protein 2
- Elongator complex protein 6
- Cytoplasmic tRNA 2-thiolation protein 1
- Diphthamide biosynthesis protein 3
- GPN-loop GTPase
- Histone acetyltransferase type B catalytic subunit
- 60S ribosomal export protein NMD3
Sequence:
MGKPKKKSDLSRAELMMMTIADVIKQLVEAHEEGKDINLNKVKTKTSAKYGLSAQPRLVDIIAAVPPHYRRALVPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNVTEAVRYSERSNTKCVGITIETRPDYCLKRHLSDMLGYGCTRLEIGVQSVYEDVARDTNRGHTVRAVCESFHLAKDAGFKVVAHMMPDLPNVGMERDVEQFIEFFENPAFRPDGLKLYPTLVIRGTGLYELWKTGRYKSYSPSALVDLVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDMGTECRDVRTREVGIQEIHHKVRPYQVELIRRDYVANGGWETFLSYEDPEQDILIGLLRLRRCSPQSFRPELKGGVSIVRELHVYGSVVPVSSRDPSKFQHQGFGMMLMEEAERIARDEHGSSKLAVISGVGTRNYYRKMGYELEGPYMVKNLY
Protein: WD repeat-containing protein DWA2 (Protein DWD HYPERSENSITIVE TO ABA 2) (Q6NPN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling. May function as the substrate recognition module within this complex leading to ABI5 degradation. Functionally redundant with DWA1.
Subcellular location: Nucleus {ECO:0000269|PubMed:20525848}.
Interaction partners:
- THO complex subunit 6
- Cullin-4
- Transducin/WD40 repeat-like superfamily protein
- Katanin p80 WD40 repeat-containing subunit B1 homolog KTN80.2
- DNA damage-binding protein 1a
- Protein ALTERED SEED GERMINATION 2
- E3 ubiquitin-protein ligase KEG
- Vacuolar protein sorting-associated protein 51 homolog
- DET1- and DDB1-associated protein 1
- DDB1- and CUL4-associated factor homolog 1
Sequence:
MQGGSSGIGYGLKYQARCISDVKADRDHTSFLTGTLSLKEENEVHLLRLSSGGSELLCEGLFSHPNEIWDLASSPFDQRIFSTVFSTGDSYGAAIWQIPEPYGQSNSSTLECVASLDAHVGKINCVLWCPSGNSDKLISMDEQNLVFWSLDSSKKSAEVLSKESAGMRHSLSGGAWNPHDVNSVAATSESSIQFWDLRTMKKNNSIERAHVRNVDYNLKREHILVSADDESGIHLWDLRKTKFPVQELPGHTHWTWAVRCNPEYEELILSVGTDSAVNLWFASASSEHKTSESPVEASRQRVNPLLNSYTDYEDSVYGLAWSSREPWIFASLSYDGRVVIESVKPFLPRR
Protein: ADAMTS-like protein 5 (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6) (Q6ZMM2)
Organism: Homo sapiens (Human)
Function: May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).
Subcellular location: Secreted {ECO:0000269|PubMed:23010571}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:23010571}. Note=Colocalized with fibrillin microfibrils. Predominantly distributed in baso-lateral regions of fibroblast extracellular matrix.
Interaction partners:
- Fibrillin-2
- Fibrillin-1
Sequence:
MGKLRPGRVEWLASGHTERPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCPPCPDTRGRAHRLLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYVWAPGHCPCPMLAPHRDYLMAVQRLVSPDGTQDQLLLPHAGYARPWSPAEDSRIRLTARRCPG
Protein: mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41) (Q8C570)
Organism: Mus musculus (Mouse)
Function: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P78406}. Note=Recruited from interphase nuclei to spindle MTs during mitosis. {ECO:0000250|UniProtKB:P78406}.
Interaction partners:
- Nuclear pore complex protein Nup98-Nup96
- Nuclear RNA export factor 1
- NKG2-D type II integral membrane protein
- Nuclear pore complex protein Nup214
- Tip-associated protein
- mRNA export factor GLE1
- Nuclear pore complex protein Nup153
- Tip-associated protein
- Nuclear RNA export factor 7
- Nuclear envelope pore membrane protein POM 121
Sequence:
MSLFGSTSGFGTGGTSMFGSTTTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPIAACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK
Protein: Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) (Q8N157)
Organism: Homo sapiens (Human)
Function: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21623382, ECO:0000269|PubMed:23532844}. Cell junction, adherens junction {ECO:0000269|PubMed:18633336, ECO:0000269|PubMed:23532844}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8K3E5}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium. {ECO:0000250|UniProtKB:Q8K3E5}.
Interaction partners:
- Coiled-coil and C2 domain-containing protein 2A
- Meckelin
- Nephrocystin-1
- Centrosomal protein of 290 kDa
- Transmembrane protein 216
- Tectonic-1
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- Tectonic-like complex member MKS1
- Tectonic-2
Sequence:
MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKEVPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPKPKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVPDCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGSFQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSNMLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE
Protein: Caspase-3 (EC 3.4.22.56) (H0Z8H6)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- E3 ubiquitin-protein ligase XIAP
- Caspase 9
- Baculoviral IAP repeat containing 2
- Poly [ADP-ribose] polymerase
- Spectrin alpha chain, non-erythrocytic 1
- Baculoviral IAP repeat containing 5
- Baculoviral IAP repeat-containing protein 5.1-like
- Apoptotic protease-activating factor 1
- non-specific serine/threonine protein kinase
- Actin beta
Sequence:
MTDIGDGAHLGKDLADTKSITGFKGKNLPASKSMDSGILPDYSYRMDYPEMGECIIINNKNFHRYTGMSPRSGTDADAASVREVFMKLGYKIKINNDLSCEGIFNLLKNVSEEDHSKRSSFVCVLLSHGDEGLIYGTDGPLELKALTSLFRGDRCRSLAGKPKLFFIQACRGTELDSGIETDSGSEETMCQKIPVEADFLYAYSTAPGYYSWRNSAEGSWFIQSLCKMLKEHARKLELMQILTRVNRRVAEYESCSTRQDFNAKKQIPCIVSMLTKEFYFPS
Protein: Proteasome subunit beta (O62102)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-2
- Proteasome subunit pbs-5
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-5
- Proteasome subunit beta
Sequence:
MATADVKSTVPHMDMDRGGAFDFSNCIRNQAMCKMGGKAPKLTSTGTTIVAVAFKGGLVMGADSRATAGNIIADKHCEKVHKLTESIYACGAGTAADLDQVTKMLSGNLRLLELNTGRKARVITALRQAKQHLFNYQGYIGAYLLIGGVDPTGPHLYMCSANGTTMAFPFTAQGSGSYAAITILERDFKVDMTKDEAEKLVQRALEAGMHGDNASGNSLNLVIIEPSETVFKGPIVPEFCKRPEPNDLVYKFQAGATKVLKHKTYKYDVVESMDITH
Protein: A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) (Q9ULX6)
Organism: Homo sapiens (Human)
Function: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:10761695}. Nucleus matrix {ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:16391387}. Nucleus speckle {ECO:0000269|PubMed:17594903}. Nucleus, PML body {ECO:0000269|PubMed:11884601}. Cytoplasm {ECO:0000269|PubMed:10748171}. Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:16391387}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF43
- ATP-dependent RNA helicase A
- Pre-mRNA-processing factor 40 homolog A
- Emerin
- Huntingtin
Sequence:
MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP
Protein: Glyoxylate/hydroxypyruvate reductase HPR3 (EC 1.1.1.79) (EC 1.1.1.81) (NAD(P)H-dependent hydroxypyruvate reductase 3) (AtHPR3) (HPR 3) (Q9LE33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate (HP) into glycolate and glycerate. Mostly active in the presence of NADPH and glyoxylate.
Interaction partners:
- Serine--glyoxylate aminotransferase
- Phosphoglycolate phosphatase 1A, chloroplastic
- Glutamate--glyoxylate aminotransferase 1
- Glycolate oxidase 2
- Glycolate oxidase 1
- Glyoxylate/succinic semialdehyde reductase 1
- Glyoxylate/succinic semialdehyde reductase 2, chloroplastic
- Phosphoglycolate phosphatase 2
- Glycerate dehydrogenase HPR, peroxisomal
- Malate synthase
Sequence:
MAESSEPPVVLLHRPPSLTFMDEILTREFRTLITDTSSSESLPSFFPRHASSARAFVISGRLPVTDELLSHLPSLQILVCTSVGIDHIDLAACKRRGIVITNAGNAFSDDVADCAVGLLISVLRRIPAADRYVRSGNWAKFGDFQLGSKVSGKRVGIVGLGSIGSFVAKRLESFGCVISYNSRSQKQSSPYRYYSDILSLAENNDVLVLCCSLTDETHHIVNREVMELLGKDGVVINVGRGKLIDEKEMVKCLVDGVIGGAGLDVFENEPAVPQELFGLDNVVLSPHFAVATPGSLDNVAQIALANLKAFFSNRPLLSPVQLD
Protein: Zinc finger protein CONSTANS-LIKE 8 (Q9M9B3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- Zinc finger protein CONSTANS-LIKE 14
- Putative zinc finger protein At1g68190
- Glyoxylase I 4
- Protein MAK16 homolog
- Pentatricopeptide repeat-containing protein At1g71460
- Trimethylguanosine synthase
- At4g01860
- Membrane lipoprotein
- Organic cation/carnitine transporter 6
- TORTIFOLIA1-like protein 4
Sequence:
MFCAEIMISKYQEDVKQPRACELCLNKHAVWYCASDDAFLCHVCDESVHSANHVATKHERVCLRTNEISNDVRGGTTLTSVWHSGFRRKARTPRSRYEKKPQQKIDDERRREDPRVPEIGGEVMFFIPEANDDDMTSLVPEFEGFTEMGFFLSNHNGTEETTKQFNFEEEADTMEDLYYNGEEEDKTDGAEACPGQYLMSCKKDYDNVITVSEKTEEIEDCYENNARHRLNYENVIAAWDKQESPRDVKNNTSSFQLVPPGIEEKRVRSEREARVWRYRDKRKNRLFEKKIRYEVRKVNADKRPRMKGRFVRRSLAIDS