wanglab/gogpt-training-data huggingface dataset:
Protein: Neoxanthin synthase, chloroplastic (EC 5.3.99.9) (Q9M424)
Organism: Solanum tuberosum (Potato)
Function: Involved in the synthesis of neoxanthin, the last product of carotenoid synthesis and a precursor of abscisic acid.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11094161}.
Interaction partners:
- Zeaxanthin epoxidase, chloroplastic
- Violaxanthin de-epoxidase
- 9-cis-epoxycarotenoid dioxygenase
- 9-cis-epoxy-carotenoid dioxygenase 2
- 9-cis-epoxycarotenoid dioxygenase
- Carotenoid cleavage dioxygenase 4
- Carotenoid cleavage dioxygenase 4
- Zeta-carotene desaturase
- NnrU domain-containing protein
- beta-carotene 3-hydroxylase
Sequence:
METLLKPLTSLLLSSPTPHRSIFQQNPPSLNPTTKKKSRKCHFRNESSKLFCSFLDLAPISKPESFDVNISLVDPNSGRAQFDVIIIGAGPAGLRLAEHVSKYGIKVCCVDPSPLSMWPNNYGVWVDEFENLGLEDCLDHKWPMTCVHINDHKTKYLGRPYGRVSRKKLKLRLLNSCVENRVKFYKAKVWKVEHEEFESSIVCDDGKKIRGSLVVDASGFASDFIEYDKPRNHGYQIAHGVLVEVDNHPFDLDKMVLMDWRDSHLGNEPYLRVNNAKEPTFLYAMPFDRNLVFLEETSLVSRPVLSYMEVKRRMVARLRHLGIKVRSVIEEEKCVIPMGGPLPRIPQNVMAIGGNSGIVHPSTGYMVARSMALAPVLAEAIVKGLGSTRMIRGSQLYHRVWNGLWPLDRRCIGECYSFGMETLLKLDLKGTRRLFDAFFDLDPKYWQGFLSSRLSVKELAILSLCLFGHGSNLTRLDIVTKCPVPLVRLIGNLAIESL
Protein: Aldehyde dehydrogenase (RF2 (EC 1.2.1.3)) (Restorer of fertility2) (T cytoplasm male sterility restorer factor 2) (Q43274)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MARRAASSLVSRCLLARAPAGAPPAAPSAPRRTVPADGMHRLLPGVLQRFSTAAAVEEPITPSVHVNYTKLLINGNFVDSASGKTFPTLDPRTGEVIAHVAEGDAEDINRAVAAARKAFDEGPWPKMTAYERSRILLRFADLIEKHNDELAALETWDNGKPYEQAAQIEVPMVARLMRYYAGWADKIHGLIVPADGPHHVQILHEPIGVAGQIIPWNFPLLMYAWKVGPALACGNTLVLKTAEQTPLSALYISKLLHEAGLPEGVVNVVSGFGPTAGAALASHMDVDKIAFTGSTDTGKIILELAAKSNLKTVTLELGGKSPFIIMDDADVDHAVELAHFALFFNQGQCCCAGSRTFVHERVYDEFVEKAKARALKRVVGDPFRKGVEQGPQIDDEQFNKILRYIRYGVDGGATLVTGGDRLGDKGFYIQPTIFSDVQDGMKIAQEEIFGPVQSILKFKDLNEVIKRANASQYGLAAGVFTNSLDTANTLTRALRAGTVWVNCFDVFDAAIPFGGYKMSGIGREKGVDSLKNYLQVKAVVTPIKNAAWL
Protein: Transcription initiation factor TFIID 150 kDa subunit (Q5BJV8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDASLFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQTDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTAHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPEAGVGNQETASNPGCHTQLAGFQNPFSSSQDEEEVDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPSSSRSSLMPQHALGCDITPTTKPQWSMELSRKGAGKEQPLEMGVHPVAAPLSVFAKEALSSARHSEHHHHHHHEHKKKKKKHKHKHKHKHKHDGKDKDKDKEPFTFSSPASGRSVRSPSLSD
Protein: Anti-proliferative protein domain-containing protein (FOG-3 protein) (G5EDX7)
Organism: Caenorhabditis elegans
Interaction partners:
- FOG-1 protein
- CCR4-NOT transcription complex subunit 7
- Sex-determination protein fem-3
- Fem-3 mRNA-binding factor 2
- Female germline-specific tumor suppressor gld-1
- Sex-determining transformer protein 2
- Protein phosphatase fem-2
- Fem-3 mRNA-binding factor 1
- Sex-determining transformer protein 1
- Nanos-type domain-containing protein
Sequence:
MYTEVRELVNFVCRYLFGHIPRRPVGIFGAELGNYLVSHFSSTWDVHHPKNGEMKRMINTTTSLCFASSAEEAGVPPSDVLRLLPTNMIIFANPGHVFVRLSENGIETPIWIGDVNCDENYQSVPEYVVRTAAIRAEPCSNLGAAGKSVLVGKKPLLTNDKAALEMVNTMYSPLAREKCDDINANLSHLREMYPFRFVYKPSSAQTFSGVEFSQTRFGSSKSRPDLQTMDVIKYLSSQQVSSSSSPSFTYSSINDQMRYSPRF
Protein: Required for respiratory growth protein 1, mitochondrial (Q12167)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:19756047}.
Interaction partners:
- Required for respiratory growth protein 8
- Genetic interactor of prohibitin 5, mitochondrial
- Mitochondrial inner membrane magnesium transporter MFM1
- Protein PET130
Sequence:
MAQNFGKIPSHKSYVLSLYRTVLRNIPKCCHSYAFQYEIKKTLSIQLFKHKHDKSSWSVYTLLNEFSLLNNCLLEGKLQEIKNLMKPLKKMKKQLKTTKILNSLTSLGDVKTNDPEEVRRFHVLSAYIKRKQDLGLLPAYIPKTYQHKLLLPLALNEHACLKLFHIQQKLKNGPPSAGLSYTKEGRNQIWFVRSPINKGRQQSKKLGILIRKERKDSQKNIDNLNFCEINAAWALHEAIWEEYLESKKIIKVNLPKYLEYAANIPKSTKCNPSSQYQKVKEWVDPVREIMFELHSKSFQRVEYFNKYKEKLLKNGGQLAYFDKKSKEMYAKRLTLFRKMSKETLPYVTLFIEGRDLPSVLAKYGF
Protein: DNA 5'-3' helicase (EC 5.6.2.3) (Q57YJ9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- [RNA-polymerase]-subunit kinase
- General transcription factor IIH subunit 4
- DNA repair and transcription factor protein, putative
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA-direcetd RNA polymerase II, subunit 9, putative
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II, putative
Sequence:
MIVVVAVTKHCTSPAGMKLFIEDVPVLFPYEYIYPEQLEYMTELKKGLDQGGHMVLEMPSGTGKTTTLLSLLIAYLHHHADEKRKVVYCTRTVGEVDKTASELRKILGLWETEEVGSRPLRGVCLTAKKNLCIEPSVVSRRHLDDVDAGCRSLTAPWQTDQRCVYFDTLENQGFDLRPGAYSLSDLKRLGEENHVCPYYLARKALKVADIVIHSFLYIVDPIVAEVTKEYMDENTIVVMDEAHNVDDVCIEAMSLIVTKDDAFQAKDNVKKLNEAVDRMKATNRQKLQEEYDRLVNGLAMAELARSGESTAGVSVQALNIPQDIAEEAIPGSLRQANHFLAFMQRLVDFTHRVVCRISRTYVADPLTFLTKVKEECSVDVRHLRYLTERLKVLLNTLQITSAHSFHNVSLIAQMFMTLSTHYTDDRYEKPGFVVVCEASDPTRPTIPDPVIRLVCVDASLALREVFAKYRSVILTSGTLSPLDIYPKMLGFSPVIAKSFQMTLSRKCIAPVVVTRSSESVNITAEEVTSSFVVRKNPEAQATVSAAYEDLLRGLAKTVPDGIVCFFTGYQYMSEVLLGWHRSGFLKELSRHKLIFVETQSVDDTATALESYRRACDIGRGAIFMSIARGKIAEGIDFDSHYGRAVVMFGVPFLPPIDEPLRQRIHWMEICLGIPGSEYRNFDAMRQASQCIGRVLRNKTDYGMMLLVDRRFALNDKRKKLPIWIQQCLKENTNLSVDAAVAVARGFFKEMAQPWEYKRDLGTTLFSVETLARKGFLKPSKSSVSRKTVDESRATTTVPPPAEEIIRPVREPDYRKRSRE
Protein: ORF K13 (P88961)
Organism: Human herpesvirus 8 type M
Interaction partners:
Sequence:
MATYEVLCEVARKLGTDDREVVLFLLNVFIPQPTLAQLIGALRALKEEGRLTFPLLAECLFRAGRRDLLRDLLHLDPRFLERHLAGTMSYFSPYQLTVLHVDGELCARDIRSLIFLSKDTIGSRSTPQTFLHWVYCMENLDLLGPTDVDALMSMLRSLSRVDLQRQVQTLMGLHLSGPSHSQHYRHTP
Protein: E3 ubiquitin-protein ligase PPP1R11 (Protein phosphatase 1 regulatory subunit 11) (Q9VMI2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH07711p
- IP04645p
- FI21959p1
- Serine/threonine-protein phosphatase
- IP09433p
- Serine/threonine-protein phosphatase alpha-2 isoform
Sequence:
MAHKQSTNNETSNGSTTEIIDETDARAQLESGRTTPTLLLRLEHPRNERRVAFHAGIIDNEHLNRKKSKCCCIYKKPLAFGESSSEDDEDCEHCFGHPEKRQRNAKHNHNHGDKPCTEASHPEGPSTSTQAAHISQPPAEPVESKTDPKPPTPGVDFEQTGSS
Protein: Semaphorin 6D (H0YMP7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDS
Protein: Odorant receptor 49b (Q9V6H2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 98a
Sequence:
MFEDIQLIYMNIKILRFWALLYDKNLRRYVCIGLASFHIFTQIVYMMSTNEGLTGIIRNSYMLVLWINTVLRAYLLLADHDRYLALIQKLTEAYYDLLNLNDSYISEILDQVNKVGKLMARGNLFFGMLTSMGFGLYPLSSSERVLPFGSKIPGLNEYESPYYEMWYIFQMLITPMGCCMYIPYTSLIVGLIMFGIVRCKALQHRLRQVALKHPYGDRDPRELREEIIACIRYQQSIIEYMDHINELTTMMFLFELMAFSALLCALLFMLIIVSGTSQLIIVCMYINMILAQILALYWYANELREQNLAVATAAYETEWFTFDVPLRKNILFMMMRAQRPAAILLGNIRPITLELFQNLLNTTYTFFTVLKRVYG
Protein: Sorting nexin-41 (Meiotically up-regulated gene 186 protein) (O60107)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Endosome membrane {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}. Endomembrane system {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}. Note=Endosome and other perivacuolar punctate structures. {ECO:0000250}.
Interaction partners:
- Sorting nexin-4
- LON peptidase N-terminal domain and RING finger protein C14F5.10c
- Sorting nexin C1711.11
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 26
- mRNA-capping enzyme subunit alpha
Sequence:
MDFFEDNNPFSGSDNRSASSAVNVEPKVEPSQHQGSSSVKENAISQPNESFQSRNMFFQKDVDSVVDSALDPNGIVITGAMKAESGSHIVYIIKLQDSEIHHRYSEFASLRVQLSRLYPTCLVPPLPDKHKIMDYLINVTKNQRMSRMLEERKRLLQLFLRRVAQHPILGLSEVFRKFLSRHVSWKEVLHSPPISCLPKDLLKAPPADPSSKENAELYKELPIPSKTLVPRDNYDDVGKNFLMLEDTLQQYSIVAQEESNLFNQIVLSNSKYCLAHSTLGAMFNALSLSESGKLLTALEKVGQANDHTCLASIDFMHNFVIAVIEPLQELSKDAKNMRHIFIFRKMKFIQQVMVEELLTRKKSFLHLLERRERHAARLQQAIGEVDGDVILNRESEATLGVNNAQTSRSTIPEEDPLFNDEESKEPSVPLMGTDQPLENYHDGNGEQTEECLRDLRHNQSQDFETVSQDTSLTSVTVLPRTIRDVFDRIRFVLNGLTDNNVEVSRHNNIGRTAESVTHLTDMLLITTKDVAFVTDRVNFEFQRYQDTHRQDLNRILNRLTDSHIDWANRNLRIWNSVQESLKTYVS
Protein: CD180 antigen (Lymphocyte antigen 64) (Radioprotective 105 kDa protein) (CD antigen CD180) (Q99467)
Organism: Homo sapiens (Human)
Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Lymphocyte antigen 86
- Lymphocyte antigen 96
- Toll-like receptor 4
- Toll-like receptor 2
Sequence:
MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI
Protein: Pyruvate kinase 1 (PK 1) (EC 2.7.1.40) (cell division cycle protein 19) (P00549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Pyruvate carboxylase 2
- ATP-dependent 6-phosphofructokinase subunit alpha
- Pyruvate decarboxylase isozyme 1
- Enolase 2
- Glucose-6-phosphate isomerase
- Pyruvate carboxylase 1
- Enolase 1
- Phosphoenolpyruvate carboxykinase
- NAD-dependent malic enzyme, mitochondrial
- Fructose-bisphosphate aldolase
Sequence:
MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV
Protein: Inner membrane protein YbjJ (P75810)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- 5-amino-6-
- Uncharacterized protein YbjH
- HTH-type transcriptional regulator RcdA
- DNA topoisomerase 4 subunit A
- 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
- Cell division topological specificity factor
- Uncharacterized protein YaeQ
- Elongation factor Tu 1
- Phosphate-specific transport system accessory protein PhoU
- Elongation factor Tu 2
Sequence:
MTVNSSRNALKRRTWALFMFFFLPGLLMASWATRTPAIRDILSVSIAEMGGVLFGLSIGSMSGILCSAWLVKRFGTRNVILVTMSCALIGMMILSLALWLTSPLLFAVGLGVFGASFGSAEVAINVEGAAVEREMNKTVLPMMHGFYSLGTLAGAGVGMALTAFGVPATVHILLAALVGIAPIYIAIQAIPDGTGKNAADGTQHGEKGVPFYRDIQLLLIGVVVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTVGRFTGGWFIDRYSRVAVVRASALMGALGIGLIIFVDSAWVAGVSVVLWGLGASLGFPLTISAASDTGPDAPTRVSVVATTGYLAFLVGPPLLGYLGEHYGLRSAMLVVLALVILAAIVAKAVAKPDTKTQTAMENS
Protein: RNase 2 (Ribonuclease like 2 precursor) (Ribonuclease-like 2) (A5HAK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Ribonuclease T2,-like
- Troponin I type 2B
- Odorant receptor, family D, subfamily 107, member 1.
Sequence:
MEILQSAVIFLLVFSFSFTVKVPDNESPYEKFLRQHVDPDMSVQKCNSEISKRKITAKAGNDCKKVNTFIQANKRDVNAVCGNAGNRVVDTNLTKSNQPFPVVTCQLKSGERRPHCQYRGRSSTRYIVLRCDKGWPVHYDEGIIDVNSSG
Protein: Otopetrin-like a, isoform C (E1JJE6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQRCPYIHEMRERLLDQPRETLQLENMERANLLDNRQSASESNQLQGDGYHTSPAHQRTPLVPHDLGEDFNLDFDDDFPIDARRPKNAKVCYTFKPNPNKYSFMPAKITVQGTYETNPITGPIELWTSLFIVTSLVYAILLIVVCIAYVISDVTTHRLPVLYYETFFTYLYGVSILFLLYVFCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDSGKAAKGAAYQHTLAKFLEAPVDAEVAVTPKNVRKRKTTHSDLTHGSFFLRVGAIAFGLGAMIYIGLEFGSFFEIPFDSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVVATNICVWIRTLVKESLLEITIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDILPKDVYKSDNVLSKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKLKKFITSATTAATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTTTTTAAALNLETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTLSPASSTEGSASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILFFVLVRHQQFSLLAIYLADASHCILMAFAILAIIVGFIRVKNLKFRCEEQSNLNDILLRISAFGLFTYSVFSIIAGSLKVLESEPSLLVTTTGGVAVFQVILQLLFIADVSRRRVHLPEHDRSKPGRQIVTFLLICNVAMFAIYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIWKTTYKARLE
Protein: Protein arginine N-methyltransferase 2 (EC 2.1.1.-) (Protein-arginine N5-methyltransferase) (Type IV protein arginine N-methyltransferase) (Type IV PRMT) (Q03305)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12 (RPL12A/RPL12B) at 'Arg-67'.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17448464}. Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17448464}. Note=Appears often very close to the nuclear membrane and the nuclear pores. {ECO:0000269|PubMed:17448464}.
Interaction partners:
- Protein arginine N-methyltransferase 1
- Ribosomal lysine N-methyltransferase 2
- Alpha N-terminal protein methyltransferase 1
- Protein arginine N-methyltransferase SFM1
- Protein arginine N-methyltransferase HSL7
- Ribosomal lysine N-methyltransferase 1
- Ribosomal lysine N-methyltransferase 3
- Ribosomal lysine N-methyltransferase 4
- Histidine protein methyltransferase 1
- Ribosome biogenesis protein BRX1
Sequence:
MSELHALLTFPERPISQSYYVPKLQHFLKSGIPATYTLEQVAAFEHEEKNRNGDKEFRESTDDNKTSNTTPLHVLARSLPLDIKDEELQVVMDMMNILFEYGAGWNFIDYEDKTVGDLFLERNQSRESPLYRRLVEAGVSAELLLRKLNGGDVEFLDTDELIGIEPEESVQTAVDGQKEESVGSDDDATAANQQVYLKTELEYKDDALITKENKDGVMMDWETKIMELASETLFPDPEATNSATILNIGFGMGIIDTFIQARKPYRHYICEAHPDVLAKMKMDGWYEKDNVVILEGRWQDTLNNLLDKGEVFFDGIYYDTFSEHYQDILDLYDVVVGLIKPEGVFSFFNGLGADRSLCYDVYKEIVEIDVATYGMKCDYTRYSLDEQLPDWNDVKRSYFNCNYYYHPRITFA
Protein: Protein kinase domain-containing protein (Q5ZI83)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKERLGRGGRDNVIRWHNKETGEQVAIKQCRQELSPRNRDRWALEIQIMKRLHHPNVVAARDVPEGMQKLAPNDLPLLAMEYCQGGDLRKYLNQLEHCCGLREEAILILLSDIASALRYLHESEDLPQRLETREHCAAARRAKVRVVYDTSLSWEHYSTWLQMHILCWDTTVLGSRAAGTAEVYGYSGLLELLAHWLLNALQASDHSYPTGSQYNGIRKCDRRVSWIFVVSEDLSGEVKFSSSLPCPNNLNSVLAGKLEKWLQLMLMWHPRQRGTDPVYGPNGCFKALDDILNLKLLHVLNMVTGTVHTYPVTEEETLQTVKARIQSDTGIPEQGSGAPAGGWSCIVYSESIQLIARWNDAVVADTDLLFLFDNQKVAYEAQVALRPHPESVDYILQDPKKNLHFFQLRKVWGQIWHTIRMLKEDCNRLQQGQRAAMMNLLRYNSTLSKMKNSMASLSQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSEKLLFAWKEMEQAVELCGREDDVDQLVKRMMALQTDIVDLQRSPLGRKQGGTLEDLEEQARELYRRLREKPRDQRTSGDSQEIVRLLLQAIQTFEKKVRVIYAQLSKTVVCKQKALELFPRVEKVMNLMNEDEETVVRLQEKRQKELWNLLKIACSKVRGPVSGSPESMNMSRLNSPGQLLLQVPSGTYALSESVRKSEELLLESQKLCSQLENVMHDTMKDQEQSFMALDWSWLQLHVEERSSPEQTHM
Protein: 8-hydroxygeraniol oxidoreductase (8-HGO) (Cr8HGO) (EC 1.1.1.-) (Alcohol dehydrogenase 10) (W8JWV8)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vincristine, quinine, and strychnine) biosynthesis pathway. Catalyzes two successive and reversible oxidation steps for the formation of 8-oxogeranial from 8-hydroxygeraniol. Active with 8-OH-geraniol, 8-OH-geranial and 8-oxogeraniol in the presence of NAD(+).
Subcellular location: Nucleus {ECO:0000269|PubMed:24710322}. Cytoplasm, cytosol {ECO:0000269|PubMed:24710322}.
Interaction partners:
Sequence:
MTKTNSPAPSVITCKAAVVWKSGEPPKVEEIQVDPPKASEVRIKMLCASLCHTDFLACNGLPVPLFPRIPGHEGVGMIESVGENVTNLKEGDIVMPLYLGECGECLNCKSGRTNLCHKYPLGFSGLLLDGTSRMSIGEQKVYHHFSCSTWSEYIVIEAAYAVKVDPRVSLPHASFLCCGFTTGFGATWRDVNVVKGSTVAVLGLGAVGLGAVQGAKSQGASRIIGLDINDKKREKGEAFGMTEFINPKGSNKSISELINEATGGLGLDYVYECTGVPALLNEAIESSKVGLGTAVLIGAGLETSGEIKFIPLLCGRTVKGSIYGGVRPKSDLPTLIEKCINKEIPMDELMTHEVSLSEINKGFEYLKHPDCVKVVIKF
Protein: GH25653p (Uncharacterized protein, isoform B) (Q9VXU3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
- BcDNA.LD23634
- CG8675-PA
Sequence:
MEALVNYSSEDDQEDAGFQIRAPQQQQQLRHLPHAKSPKTTTDSLLKQKNNNNYGSGNSPRGKEREREREREREKTKPMSQQQSHRSSSRGRIDEEPKPSSRHRQERDKDRERDRDRERDRDKDKKRSDSERSRDKGRDKNHSKGDHRHHRTKDGDSHRERERDRDRERERDRDKDRDRRRSEKSSRHHSGKERHHHHHNNSSSAAAAAVSAASVRRSHDERSRRRRDSRSGSRTPTGTPPSRRRHQSQQSRKYRERDSSSRSRSPKEEQATTLRGGAVAGSHMLLAKSGGGAGSTATNATAAARVAAAALVAANATAAAMAAGSSGGGGGGLLPTPNYAPKIPSLMSLELSTPAAAAPVAEPIQLPSYYNPSIINANRYAEQQQKRKLLWGSKKSENSANKWGNAHFSQDSDGKVASKFMRLMGIKNAGTSGNDDGKGGQAESTNGSAAGEGNRAVRGAAPSGAAGGTKVPTDVQQRQRMFSNMEQQYEMARAATHTMRGVGLGFGSQPRTF
Protein: Protein DMP6 (AtDMP6) (Q9FNL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in membrane remodeling.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:20712629}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEINVDEEAGIIKEETVPLLDDQNRNRDLPDIERNTMMQKAIGKTFQTTANLANLLPTGTVLAFQILSPICTNVGRCDLTSRFMTALLVSICGFSCFILSFTDSYKDLNGSVCYGFATIHGFWIIDGSATLPQELSKSYKLRFIDFVHAIMSFLVFGAVVLFDQNVVNCFYPEPSAEVVELLTTLPVAVGVFCSMVFAKFPTTRHGIGFPLSAK
Protein: Protein phosphatase (EC 3.1.3.16) (A0A1D8PL06)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MSMLLTILSKKNGVSLGSSFIKTSARSFASSSRSYWGGYGKGSARDYSTAASPSATASAASMNYDSALTSVSHYNIAVAFQPKDREESNLFKKKQPSPSLQSPSGEDNLFVSNEKAGCIAVGVADGVGGWSEAGYDSSAISRELCASLRRQFESGTESNPKQLLSLAFKEVLSSPQVEIGGTTACLGVLTSDLKLHVANLGDSWCGLFRDSKLINETNFQTHNFNTPFQLAKIPEEIVRQAKLQGRRYIIDSPEAADEYTWDLKSGDVVMFATDGVTDNVIPQDIELFLKDHEETNQLDDVANKFVKEVVKVSKDSNFPSAFAQELSRLTGQKYLGGKEDDITVVLVKVK
Protein: Muscleblind-like protein 2 isoform D (Muscleblind-like-splicing regulator 2) (A0A2R8QF26)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MALNIASIRDTKWLTLEVCREFQRGNCARGETDCRFAHPSDSPMIDTSDNTVTVCMDYIKSRCSREKCKYFHPPAHLQAKIKAAQHQANQTAVAAQAAAAAMAFPHGVLQPLPKRPALEKSNGASTLFNPSVLHYQQALASAQLQQPTAAFFPTVPMMYSATPATVSAATTPATSVPYATTAPANQIILK
Protein: Sulfotransferase domain-containing protein (Q4TTA0)
Organism: Caenorhabditis elegans
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase
- Heparan sulfate 2-O-sulfotransferase hst-2
- D-glucuronyl C5-epimerase
- GlyPicaN
- Probable syndecan
- WAP-type 'four-disulfide core
- LONg
- Xylosyltransferase sqv-6
- Exostosin-like-3 homolog
- Putative extracellular sulfatase Sulf-1 homolog
Sequence:
MKYRLLLILHLIDLISCGVIPNTSKKRFPDAIIVGVKKSGTRALLEFLRVNPLIKAPGPEVHFFDKNFNKGLEWYREQMPETKFGEVTIEKSPAYFHSKMAPERIKSLNPNTKIIIVVRDPVTRAISDYTQSSSKRKRVGLMPSFETMAVGNCANWLRTNCTTKTRGVNAGWGAIRIGVYHKHMKRWLDHFPIENIHIVDGEKLISNPADEISATEKFLGLKPVAKPEKFGVDPIKKFPCIKNEDGKLHCLGKTKGRHHPDVEPSVLKTLREFYGPENKKFYQMINHWFDW
Protein: Aspartyl protease 37 (EC 3.4.23.-) (Q7XV21)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Anther-specific aspartic protease involved in tapetal programmed cell death (PCD). Directly regulated by the transcription factor EAT1/DTD in anthers during tapetum PCD and degeneration.
Interaction partners:
- Cysteine protease 1
Sequence:
MNAAVLLLLLALAALPASCAPPRSFRLELASVDASAADAANLTEHELLRRAIQRSRYRLAGIGMARGEAASARKAVVAETPIMPAGGEYLVKLGIGTPPYKFTAAIDTASDLIWTQCQPCTGCYHQVDPMFNPRVSSTYAALPCSSDTCDELDVHRCGHDDDESCQYTYTYSGNATTEGTLAVDKLVIGEDAFRGVAFGCSTSSTGGAPPPQASGVVGLGRGPLSLVSQLSVRRFAYCLPPPASRIPGKLVLGADADAARNATNRIAVPMRRDPRYPSYYYLNLDGLLIGDRAMSLPPTTTTTATATATAPAPAPTPSPNATAVAVGDANRYGMIIDIASTITFLEASLYDELVNDLEVEIRLPRGTGSSLGLDLCFILPDGVAFDRVYVPAVALAFDGRWLRLDKARLFAEDRESGMMCLMVGRAEAGSVSILGNFQQQNMQVLYNLRRGRVTFVQSPCGALR
Protein: Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase) (Q9HDU5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- UDP-glucose 4-epimerase uge1
- Bifunctional protein gal10
- Galactokinase
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Uncharacterized protein PB2B2.11
- Phosphoglucomutase
- Probable UDP-N-acetylglucosamine pyrophosphorylase
Sequence:
MTSKKFDFTEYSHRRYNPLTDSYVLCSPHRAKRPWQGAKEEIKKDDTVKYDPTCYLCPGNIRATGFENPKYETTYVFPNDYPAVRVDQPDYMQDESEITKGNTLKTRMFKTEGVKGKCFVICFCPNHNLTLPLMSAEAICNVVETWKHLYVTLKKESLEGPIRYKYLQIFENKGSAMGCSNPHPHGQAWCLDVIPSVVAQEMCNMTKYFELNNSHLLGDYVKLEMLEKERIVVENDSFIVVVPYWALWPFETLLIAKEHLKSLEEFEEKQKVDLASALKMLTTKYDNLFNTSFPYSMGLHQAPLYGSNEEVENSWFHMHFYPPLLRSATVKKFCVGFEMLGEPQRDLTSEQAAARLQELDGQKHYKNLL
Protein: Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) (P20959)
Organism: Bos taurus (Bovine)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P17936}. Nucleus {ECO:0000250|UniProtKB:P17936, ECO:0000269|PubMed:12912978}.
Interaction partners:
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin-like growth factor-binding protein complex acid labile subunit
- Insulin-like growth factor-binding protein 3 receptor
- Insulin
- Insulin-like growth factor 1 receptor
- Insulin-like growth factor-binding protein 1
- Insulin-like growth factor-binding protein 5
- Insulin-like growth factor-binding protein 7
- Receptor protein-tyrosine kinase
Sequence:
MLRARPALWAAALTALTLLRGPPAARAGAGTMGAGPVVRCEPCDARAVAQCAPPPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVGRLRPYLLPSASGNGSESEEDHSMGSTENQAGPSTHRVPVSKFHPIHTKMDVIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNMLSPRGIHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGFDVKGKGDVHCYSMESK