wanglab/gogpt-training-data huggingface dataset:
Protein: Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Spacer peptide 2 (SP2) (p1); p6-gag] (P03347)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
Function: Mediates, with Gag-Pol polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).
Subcellular location: [Gag polyprotein]: Host cell membrane {ECO:0000250|UniProtKB:P12493}; Lipid-anchor {ECO:0000250|UniProtKB:P12493}. Host endosome, host multivesicular body {ECO:0000250|UniProtKB:P12493}. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. {ECO:0000250|UniProtKB:P12493}.; SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane {ECO:0000250|UniProtKB:P12493}; Lipid-anchor {ECO:0000250|UniProtKB:P12493}. Host nucleus {ECO:0000250}. Host cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000250|UniProtKB:P12493}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion {ECO:0000250|UniProtKB:P12493}.
Interaction partners:
Sequence:
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSSQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNTATIMMQRGNFRNQRKMVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPFLQSRPEPTAPPEESFRSGVETTTPPQKQEPIDKELYPLTSLRSLFGNDPSSQ
Protein: Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) (Q9UQB9)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Subcellular location: Nucleus. Chromosome. Chromosome, centromere {ECO:0000269|PubMed:27332895}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15938719}. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.
Interaction partners:
- Inner centromere protein
- Baculoviral IAP repeat-containing protein 5
- Borealin
- Aurora kinase B
- Histone H3-like centromeric protein A
- Cyclin-A2
- Cyclin-dependent kinase 1
- Kinetochore protein NDC80 homolog
- Histone H3.3C
- Histone H3.1t
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Protein: Maleylacetate reductase 1 (EC 1.3.1.32) (Maleylacetate reductase I) (P27137)
Organism: Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
Interaction partners:
Sequence:
MKKFTLDYLSPRVVFGAGTASALPDEIGRLGARRPLVLSSPEQRELAKDIVRPIGDRVAGYFDGATMHVPVDVIQKAERAFNDTDADSIIAIGGGSTTGLAKILSMNLDVPSLVIPTTYAGSEMTTIWGVTEGGMKRTGRDPKVLPKTVIYDPLLTVDLPLAISVTSALNAIAHAAEGLYSADLNPVLETMCKQGICALFDAIPRLVAKPTDAEARTDALFGAWMCGTALCHLGMGLHHKLCHTLGGTLNLPHAETHAIVLPHALAYNLPYAAPAERLLQEVAGSSDVPSALYDLARNAGAPLSLAEIGMRPEDIPRVRDLALRDQYPNPRPLESDALETLLVNAFRGRRPDFK
Protein: Nucleoside diphosphate kinase (EC 2.7.4.6) (Q93576)
Organism: Caenorhabditis elegans
Interaction partners:
- Ribonucleoside-diphosphate reductase large subunit
- Thymidylate kinase
- dUTP diphosphatase
- Inosine triphosphate pyrophosphatase
- Guanosine-3',5'-bis
- CTP synthase
- guanylate kinase
- Adenylate kinase
- Probable adenylate kinase isoenzyme ZK673.2
- Adenylate kinase isoenzyme 1
Sequence:
MSNTERTFIAIKPDGVHRGLVGKIIARFEERGYKLVALKQMTASKAHLEVHYQDLKDKPFFPSLIEYMSSGPVVAMVWQGLDVVKQGRSMLGATNPLASAPGTIRGDFCIQTGRNICHGSDAVDSANREIAHWFKQEEINDYASPFINSWVYE
Protein: Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (PtdIns-3-kinase p101) (p101-PI3K) (Q5SW28)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O02696}. Cytoplasm {ECO:0000250|UniProtKB:O02696}. Cell membrane {ECO:0000250|UniProtKB:O02696}; Peripheral membrane protein {ECO:0000250|UniProtKB:O02696}. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250|UniProtKB:O02696}.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- GTPase KRas
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- GTPase HRas
- Phosphoinositide 3-kinase regulatory subunit 6
Sequence:
MQPAATTCTEDRIQHALERCLHGLSLGRRSAPWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTQEVQEKGTYDLLAPLALLFYSTVLCTPHFPPDSDLLLKAASTYHCFLTWPVPYCSICREMLTFIDAELKAPGISYQRLVRAEQGLPVRSHRSSTVTVLLLNPVEVQAEFLAVADKLSTPGQSPHGTYTTLLLHAFQATFGAHCDLPKLHRKLQSKTIEELEDIFTETTEAQELASGIGDVAEAREWLRTKLQAVGEKAGFPGILDTASPGKLHTIPIPVARCYTYSWNQDSFDILQEVLLKEQELLQPGILGDDEEEEEEDLEMDRHCAERDSLLSTSSLVSHDSTLLLTSSQASEPVLSRQMLTTFVSGLSDGMDSGYVEDSEENSEWPQKPGSQKRQGHRRPGQKFNRFYKLLKSTSQLVLRRDSRSLESSVDPTLPLRRAGSLCSPLDCPAQLPSRAQRSRSLPQAKLTTQLPRWLLAPPSHHQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSKLRRLETSHPILTRFFKLQFFYVPVKRSHGTSPSACPSSLSQASPLPADSLKYPSPTDLGMAPWEDSTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKADSRPLEGSATQLPILADMLLYYCRFAARPVLLQVYQTELTFVTGEKTTEIFIQSLELGHSATTRAIKASGRGRKRLGIDDDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLSKACQKPEELDSSMEALTLTLTEVVKRQNPKSKKGFNQISTSYIKVDKVQIIGSSSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSSLPPERSFSQPAETGSDLCSLLCLPIMTFSGALP
Protein: Zinc finger E-box-binding homeobox 1 isoform X1 (Zinc finger E-box-binding homeobox 1a) (F1QMZ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADGPRCQRRKQRQPRRNNVRSLCSVPEATSDSDDEDKLQIVEEDGVAEDLDQKPTVLQLKAAQQNSDTCTQDDGSLGPETLIREIRVKEECVSDEEDGAQDEATSEEKQTKTEPVYPDAAEEHQRTPERGVHDENGTPDAFSHLHNCPHCSRGYKRHTSLKEHIKLRHEKNDDNYCCSLCSYTFTYRTQLVRHMTAHRQLREKRTVTQSGSRKFKCTECSKAFKYKHHLKEHLRIHSGEKPYECPNCRKRFSHSGSYSSHISSKKCSSIIGVTRTPGVKTTITIPRPTHILLREKVVNITNKPPQKQLTLKQIKQEPVEHQPKPASATPAMAATTTNGVVAPQSVLQTLVLPTVGLVQPISINLSDLQNALNVAMDSNVMRQMVTSTNANGTSAKIVGQVPAQTQAVVLQPQQTQSQTQPQVISAISLPVVGQDGNPKIIINYNPQLDRQLKAVKVNTTQPAVGQTNVTQTNSTTSNVPQPKVLQVHSLQSSSSENQASGTAKPTQVNIIKPVQMGNLSKTPSIIKITPAQAARLAQARAAQPKLTHQTLLLVRRADGSQSLVVRQMPVTNSNTQATELKSTPEKTTDTATEETKETDNTENCEEQNLTAPIGIQIKTEPESPSKIEPEIQSEGEGEMQADENEEEETETASKTDKVSCSGTVHAGVSCGDNFHNYAYCLLCDSCPGKRKMLESKESNAKASPTTISLNSLLDKDKSGAAERLLPLLKAYSQNPEPTEEQLAQVAKTVKLPLAAVTKWYEKMRSKRILLQATGNSKNKKTPPSPESQEPTSTQDTRTPSPTPPPDSSPSEEEQNRSTASPASPPASVSTDDLVIVKTEEVEEELQCEPLDLSLPKSSSTLPGTITKLPVSSQKEPLNLSSLNKQTLAGNTIYVAQGSTGPLNIMSASLPTLVAIAEPGGVPCISSAISGNKRTILIPQLTYTYNSTEAPNNALTEKKSMVILNNSPKMADVTSDCTSEEQNDEEMQIIKRRKTFTGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECSICNKAFKHKHHLIEHTRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRETQELPEHISTSTTPPSQPDSDERESDEEEEEEEEEDDLSAVDMSDIRVVQIGDEYDDEEESGVEEETEDGGMIMELELGENVETEETREDTVFTSNEENMEMETED
Protein: DASH complex subunit DAM1 (Outer kinetochore protein DAM1) (Q5APC8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:21571923, ECO:0000305|PubMed:21549601}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9HDZ6}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:21549601, ECO:0000269|PubMed:21571923}. Note=Localization to the kinetochore is independent of microtubules. {ECO:0000269|PubMed:21571923}.
Interaction partners:
- DASH complex subunit DAD1
- DASH complex subunit DAD2
- DASH complex subunit SPC34
- DASH complex subunit DAD3
- DASH complex subunit SPC19
- Spindle pole body component
- DASH complex subunit ASK1
- DASH complex subunit DUO1
- DASH complex subunit DAD4
- Mitochondrial 54S ribosomal protein YmL11
Sequence:
MSSSKPVTPRNDRRQNSGRRHSHRSSGIQLPSMSPKVHHYPIDAENLPMDSPEIVEKFASLAESMETLDLHMHDLCHIHDHISNQFNESFASFLYGLSMTMWCVDFPGCPSREQWEALISKRERKERIEVLKKRLADAQKLNDRLKLRLSDEAKQKPQQLTSQQRPTHGPTRQIKQQPRSVNFNTHSSDSISTNSYTSGDFNTNRRVSRIPQPSRSNLPSSRFQAPSKSGPNLNQPPRYMRGLFDGNNTLNTSNYSRIKKPIHNRSVNNLQNRPPFR
Protein: Serine hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9) (O75884)
Organism: Homo sapiens (Human)
Function: Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.
Interaction partners:
- Threonylcarbamoyl-AMP synthase
- Regulatory solute carrier protein family 1 member 1
Sequence:
MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA
Protein: Cytoplasmic envelopment protein 3 (P0CK52)
Organism: Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Function: Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
Subcellular location: Virion tegument {ECO:0000255|HAMAP-Rule:MF_04042}. Virion membrane {ECO:0000255|HAMAP-Rule:MF_04042}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_04042}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04042}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_04042}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_04042}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04042}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_04042}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_04042}. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). {ECO:0000255|HAMAP-Rule:MF_04042}.
Interaction partners:
Sequence:
MGALWSLCRRRVNSIGDVDGGIINLYNDYEEFNLETTKLIAAEEGRACGETNEGLEYDEDSENDELLFLPNKKPN
Protein: Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Q6ZWU9)
Organism: Mus musculus (Mouse)
Function: Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P42677}.
Interaction partners:
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS28
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS11
Sequence:
MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
Protein: Growth hormone secretagogue receptor type 1 (GH-releasing peptide receptor) (Ghrelin receptor) (A8CGH5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MRSWPNRTDCLSPVNCSWEENYWNYYFNGSYRGPVPPENLFPIPVLMGITITCALLFLAGVTGNVMTILVVSKYRDMRTTTNLYLCSMAVSDLLIFLCMPPDVYRLWKYRPWIFGDTFCKLFQFVSECCTYSTILNITALSVERYLAICFPLRAKRLVTKRRVRALIIFLWLVSLLSAGPVFVLVGVEHETRPAAGNSVTAGGAEGQTEIDTSECKPTQYAVESGLLAAMALVSSVFFFLPVFCLTVVYSLIGRRLWKRRRENSIGANVAHRDKSNRQTVKMLGRVQYMLLIFKTMF
Protein: A-type potassium channel modulatory protein KCNIP1 (Kv channel-interacting protein 1) (KChIP1) (Potassium channel-interacting protein 1) (Vesicle APC-binding protein) (Q9NZI2)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10676964}; Peripheral membrane protein {ECO:0000305|PubMed:10676964}. Cytoplasm {ECO:0000269|PubMed:10676964}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R426}.
Interaction partners:
- A-type voltage-gated potassium channel KCND3
- A-type voltage-gated potassium channel KCND2
- Voltage-gated potassium channel KCNC1
- A-type potassium channel modulatory protein DPP6
- A-type voltage-gated potassium channel KCND1
- A-type potassium channel modulatory protein KCNIP2
- Kv channel-interacting protein 4
- Regulator of microtubule dynamics protein 3
- Factor VII-activating protease
- Serine/threonine-protein kinase Kist
Sequence:
MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDELEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEDTFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM
Protein: Neurensin-1 (Neuro-p24) (Vesicular membrane protein of 24 kDa) (Vesicular membrane protein p24) (Q8IZ57)
Organism: Homo sapiens (Human)
Function: May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P97799}.
Interaction partners:
- Serine/threonine-protein phosphatase with EF-hands 2
- Adenylate kinase 9
- Ribonucleoside-diphosphate reductase large subunit
Sequence:
MSSCSNVCGSRQAQAAAEGGYQRYGVRSYLHQFYEDCTASIWEYEDDFQIQRSPNRWSSVFWKVGLISGTVFVILGLTVLAVGFLVPPKIEAFGEADFVVVDTHAVQFNSALDMYKLAGAVLFCIGGTSMAGCLLMSVFVKSYSKEEKFLQQKFKERIADIKAHTQPVTKAPGPGETKIPVTLSRVQNVQPLLAT
Protein: P2Y purinoceptor 6 (P2Y6) (Q9ERK9)
Organism: Mus musculus (Mouse)
Function: Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- P2X purinoceptor 4
- P2X purinoceptor 1
- P2X purinoceptor 7
- P2X purinoceptor 2
- P2X purinoceptor
- P2X purinoceptor 6
- P2X purinoceptor 3
- Triggering receptor expressed on myeloid cells 2
Sequence:
MEQDNGTIQAPGLPPTTCVYREDFKRLLLTPVYSVVLVVGLPLNICVIAQICASRRTLTRSAVYTLNLALADLMYACSLPLLIYNYARGDHWPFGDLACRFVRFLFYANLHGSILFLTCISFQRYLGICHPLASWHKRGGRRAAWVVCGVVWLAVTAQCLPTAVFAATGIQRNRTVCYDLSPPILSTRYLPYGMALTVIGFLLPFIALLACYCRMARRLCRQDGPAGPVAQERRSKAARMAVVVAAVFAISFLPFHITKTAYLAVRSTPGVSCPVLETFAAAYKGTRPFASVNSVLDPILFYFTQQKFRRQPHDLLQRLTAKWQRQRV
Protein: Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) (Q15436)
Organism: Homo sapiens (Human)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity).
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000305|PubMed:8898360}; Peripheral membrane protein {ECO:0000269|PubMed:8898360}; Cytoplasmic side {ECO:0000269|PubMed:8898360}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8898360}; Peripheral membrane protein {ECO:0000269|PubMed:8898360}; Cytoplasmic side {ECO:0000269|PubMed:8898360}. Cytoplasm, cytosol {ECO:0000269|PubMed:8898360}. Note=Enriched at endoplasmic reticulum exit sites, also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:8898360}.
Interaction partners:
- Protein transport protein Sec31A
- Protein transport protein Sec24D
- Protein SEC13 homolog
- Protein transport protein Sec24A
- Protein transport protein Sec24B
- Protein transport protein Sec24C
- Small COPII coat GTPase SAR1A
- Vesicle-trafficking protein SEC22b
- Protein transport protein Sec16A
- Protein transport protein Sec31B
Sequence:
MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPLTQATRGPQVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQFVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA
Protein: Toll-interacting protein (Q7ZV43)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H0E2}. Endosome {ECO:0000250|UniProtKB:Q9H0E2}. Early endosome {ECO:0000250|UniProtKB:Q9H0E2}. Note=Localized to endo/exosomal vesicles. {ECO:0000250|UniProtKB:Q9H0E2}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 2.
- Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4.
- Toll-interleukin 1 receptor
- Toll-like receptor 18
- TNF receptor-associated factor 6
- Target of Myb protein 1 isoform 1
- Evolutionarily conserved signaling intermediate in Toll pathway
- Interleukin-1.
Sequence:
MATTISTQRGQVYIGELPQDFLRIMPTQQQQQVQLDAQAARQLQYGGSLGTAGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPENLREGTVVDEWYSLSGRQGDDKEGMINLVMSFATIPAGMMMQPQPVVLMPTVYQQGVGYVPIAGVPGMYNQGVVPMGMPAAAPVASQSAPCSEEDLKALQDMFPNLDKEVIRTVLEAQQGNKDAAINSLLQMAEEL
Protein: MRG domain-containing protein (H1UBJ2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRIAMKQSEVNKLDTTPHSKPSQFDAVFTSQSNFISRADIKKKEKSERLTKLEEEVAKKRLKYCIHACRIFPVQVYDVNVESVTVKSKNSKNWAVVNDSELQKGLRIAIRNSYINDKLRAKLANQLSNGTISLPLDLHPPFAAFTNTLQLVHLLSVIFNFRPPETLSHHDLCIRERWTKESLNRDWSTLCDAVIYLCIFIGMSHTKLKYTDPHHNLIALASFVVNDYNNINRIGSRPMCDLSEVHALIEAQRPEDCQKKDELDESWTFVD
Protein: Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) (Q13324)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22689579}; Multi-pass membrane protein {ECO:0000269|PubMed:22689579}.
Interaction partners:
- Urocortin-2
- Urocortin-3
- Urocortin
- Corticoliberin
- Corticotropin-releasing factor-binding protein
- Guanine nucleotide-binding protein G
- Corticotropin-releasing factor receptor 1
- Pro-opiomelanocortin
- Appetite-regulating hormone
- Adrenocorticotropic hormone receptor
Sequence:
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV