wanglab/gogpt-training-data huggingface dataset:
Protein: Cell cycle negative regulator roughex (P50445)
Organism: Drosophila melanogaster (Fruit fly)
Function: Negative regulator of both mitosis and meiosis. Required for the establishment of the G1 phase in the developing eye.
Interaction partners:
- G2/mitotic-specific cyclin-A
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B
- G1/S-specific cyclin-E
Sequence:
MSAPEEHKETPLEVIHEFINGVDDGTIRRDLGEDCILSFYSRNVRGAKAITGFLRNQLTMRYKHEGFEEAAQIEWGDELLLKARFGRSFDSERRRIYEEKERTGTTLHVRPESDDEEVNEKFSSTLITPPRPSSYNLNSLKYVEACGLLNKRNEHIYGGLDMGESCAVHLTLGYRSTFLPGGQVSGFEICLAVYDRGLTSLKRSTLIPPLCSISFARRASARCNPTTDDEEDTEEDSTPPTARRCVRRTLFTEENTQKEEDADFIPVVEQEQPAPQEQPAPQQAEETGEVVIPVDISTALKTTNFSSCTPRKRQQATNGNEVVRKRATGPRRMRF
Protein: Ras-related protein RABG3c (AtRABG3c) (Ras-related protein Rab73) (AtRab73) (Ras-related protein Rab7D) (AtRab7D) (Q9LW76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta 1
- Vacuolar fusion protein MON1 homolog
- Protein VACUOLELESS1
- Vacuolar sorting protein 18
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein-sorting-associated protein 33 homolog
- Rab escort protein 1
- Geranylgeranyl transferase type-2 subunit beta 2
- ADP-ribosylation factor
Sequence:
MASRRRVLLKVIILGDSGVGKTSLMNQFVNRKFSNQYKATIGADFLTKEVQIDDRIFTLQIWDTAGQERFQSLGVAFYRGADCCVLVNDVNVMKSFENLNNWREEFLIQASPSDPENFPFVVLGNKTDVDGGKSRVVTEKKAKSWCASKGNIPYFETSAKDGVNVDAAFECIAKNALKNEPEEEVYLPDTIDVAGARQQRSTGCEC
Protein: Probable 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-like protein C285.04) (O74492)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Interaction partners:
- Uricase
Sequence:
MASNPPQPQGPALTAHILNTMSGIPAAGVQVALFKLNESPTPSQQFIATTETNANGRVTSWNVDLSTVESGIYTFRFETGAYFDSLGVTSFYPYVEMAVRINKGQHYHIPLLLAPYGYTTYRGS
Protein: No extended memory, isoform A (EC 1.-.-.-, EC 1.16.1.7) (RE01022p) (Q7JR72)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDTNSVSPLPPMEEAMDRVSEKSPPGTPNGIEMPPPPDEKRYEEDPDNAWNCCSWCEYLLIVILSTILLVGVLVLTLFWVMFYRDGFAWSESPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEKERETVNEAGVSSENKLVEHYITSAIGVTLIFIGIIVTFAVRRSNAPASAKVYVTERI
Protein: Cuticlin-1 (Q03755)
Organism: Caenorhabditis elegans
Function: Component of the cuticles, which contributes to the formation of extracellular envelopes protecting the organism from the environment (Probable). Plays a role in alae formation in dauer larvae.
Subcellular location: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000305|PubMed:15936343}.
Interaction partners:
- Cuticlin 2
- ZP domain-containing protein
- Cuticle collagen 36
- Ground-like domain-containing protein
- PAN domain protein
Sequence:
MTWKPIICLAALVLSASAIPVDNNVEGEPEVECGPNSITVNFNTRNPFEGHVYVKGLYDQAGCRSDEGGRQVAGIELPFDSCNTARTRSLNPKGVFVSTTVVISFHPQFVTKVDRAYRIQCFYMESDKTVSTQIEVSDLTTAFQTQVVPMPVCKYEILDGGPSGQPIQFATIGQQVYHKWTCDSETTDTFCAVVHSCTVDDGNGDTVQILNEEGCALDKFLLNNLEYPTDLMAGQEAHVYKYADRSQLFYQCQISITIKDPGSECARPTCSEPQGFGAVKQAGAGGAHAAAAPQAGVEEVQAAPVAAAAPVAAPVAAAAAAPAVPRATLAQLRLLRKKRSFGENEGILDVRVEINTLDIMEGASPSAPEAAALVSEESVRRRATSTGICLTPIGFASFLGIGTIVATALSATIFYVARPTSHKH
Protein: RH52661p (Q8IGD1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
DSQCKMGSNTGAWILLGLLAGIASLSSAANIQRNEDQTILQNNGNTFLSNGAGQIIRGPDGKTVLIGSDGRRIITDADSSEEDSSHDYGHGGSYNNVIINGGSGSSVIHGDGHSFIVGDASHGSYMNSNGRSIRIINGAIELNDHGQVYTFRPKAAGINEKETVTINGQPAQVEYSNGDIVIELADHTVIAKIGGRAFLGDRESFDNRDKLEAEAKNYADRIQQEVHANLQKTMADIQRDLQNSLGNIFY
Protein: GH23838p (I[[h]] channel, isoform M) (Q95T40)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYVSTSGSFWQRSVL
Protein: Large ribosomal subunit protein P3y (60S acidic ribosomal protein P3-2) (Q9LVC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL24z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL24y
- Large ribosomal subunit protein uL10y
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL4y
Sequence:
MGVFSFVCKSKGGEWTAKQHEGDLEASASSTYDLQRKLVQTALSADSSGGVQSSFSLVSPTSAVFVVVIGGGGGGGFAAGGGAAAGGGGGGEAAAATKEEEKKKEESEEEEGDFGFDLFG
Protein: Non-classical export protein Nce102, putative (Q4WIJ9)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MALKGIQLGLRAWEFVFSLLVMALIGNIIAMAFAGNPATINYSMFTATFSIISLFYLVPASINLNWAIHPIIMIVLDVLNNIFFLTCAIALAARLECHSCSNDEYTLHNEITNGAHNRQKRCREAQASVAFLWFAWAGYMASTIISILMARSATVDLRSRTGRAPRVARPSMAQV
Protein: MOXD1 homolog 2 (Q6NP60)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein, isoform D
- Uncharacterized protein, isoform G
- Prolyl 4-hydroxylase alpha subunit domain-containing protein
Sequence:
MAHPRKAVATPATLQLGPPAQTAQSPAATLRHSRTASSSRRLSLIRCFISCHTFNLFLLLLLLASGVRAASKLATRSNKTSGSSTASGVGAGTAATSAAAAAASGTPIWDHAIDLNDDFRILWQIINQDITFEIQARTLGYVGFGFSPDGNLAGADMAIGWVDKGQTYFQDRHVTRNGDPEPVVDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSHDIAITNDTMRLLYMYHAQDPPHGSVRPGTLPDPARAFRPYRPMVLMQRAQLPMPSPTHDERVRVLELRNEDVELPAGDLPLFWCKMFKLEDINRKHHLIRYEPIYDSSSSVHYLQHITLHECQGAHAELEEMAREQGRPCLGARSIPLACNAIVASWSRGSEGFTYPHEAGYPIESRQAKYYLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHVLRPNDAGTLSIGMDPNWRHIIPPGQKRVVSEGQCIEDCTGYAFPQQGINIFAVMMRTHQIGKEVKLRQIRQTEELPPIAHDSNIDVAYQDFRRLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEESCTVLTLYYPRQKKLTTCHSLPSLPTVLHSLGIEQLATDSNPVLISSPPELAGMTLEARLISYDWENQFGEFQEATRKGSFKPICWGAKNHVVPGSEFLEGYSINVTKTYKKHRRCKPKRPLAPPTERTAPPPASDLSELPVLHELDNNNIIEGAARSSRSSATDVHSLSRGSGRHFISCLLWLGASSWWLLLMLRT
Protein: Digalactosyldiacylglycerol synthase 2, chloroplastic (EC 2.4.1.241) (Q8W1S1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha-glycosidic linkages. During phosphate shortage, involved in the biosynthesis of digalactosyldiacylglycerol (DGDG) which rescues the limitation of phospholipids (Probable).
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:14600212}.
Interaction partners:
- Monogalactosyldiacylglycerol synthase 2, chloroplastic
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
- Monogalactosyldiacylglycerol synthase 1, chloroplastic
- Galactolipid galactosyltransferase SFR2, chloroplastic
- Digalactosyldiacylglycerol synthase 1, chloroplastic
- UDP-sulfoquinovose synthase, chloroplastic
- Sulfoquinovosyl transferase SQD2
- U11/U12 small nuclear ribonucleoprotein 25 kDa protein
- Phosphatidate cytidylyltransferase 4, chloroplastic
- Phosphatidate cytidylyltransferase 5, chloroplastic
Sequence:
MTNQQEQHIAIFTTASIPWLTGTAVNPLFRAAYLANDGERRVTLVIPWLTLKHQKLVYPNSITFSSPSEQEAYVRQWLEERVSFRLAFEIRFYPGKFAIDKRSILPVGDISDAIPDEEADIAVLEEPEHLTWFHHGQKWKTKFNYVIGIVHTNYLEYVKREKQGRVKAFFLKYLNSWVVGIYCHKVIRLSAATQEYPKSIVCNVHGVNPKFLEIGLRKLEQQKLQEQPFTKGAYYIGKMVWSKGYKELLKLLEKHQKELAELEVDLYGDGEDSEEIKEAARKLDLTVNVYPGRDHADSLFHNYKVFLNPSTTDVVCTTTAEALAMGKIVVCANHISNKFFKQFPNCRTYDDGQGFVRATLKALGEQPSQLTEQQRHELSWEAATQRFIKVSDLNRLSRADSNLSKRSVFASSSISVGKNLEDMSAYIHFLASGFEASRTAFGAIPGSLQPDEELCRDLGLSLNTPSPNTRKQD
Protein: GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (TGF-beta-related neurotrophic factor receptor 1) (P97785)
Organism: Mus musculus (Mouse)
Function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. {ECO:0000250|UniProtKB:Q62997}.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Neurturin
- Glial cell line-derived neurotrophic factor
- Artemin
- Persephin
- Beta-nerve growth factor
- Neurotrophic factor BDNF precursor form
- Neural cell adhesion molecule 1
- Nanos homolog 2
- Deleted in azoospermia-like
Sequence:
MFLATLYFVLPLLDLLMSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDVACTERRRQTIVPVCSYEERERPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRIKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDNDYGKDGLAGASSHITTKSMAAPPSCGLSSLPVMVFTALAALLSVSLAETS
Protein: Copper transport protein (Q8MQM5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU367022}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367022}.
Interaction partners:
Sequence:
MDHAHHSAPGVDHSMHHDHVGMHHDHSGIPAATASPMDAASMFDLIPDTSDLQASHAGHAAHGAHNHGGGSGTGMEHMMPMAFHFGYNETILFSWWHIETVAGLIGSMIAIFLLALMYEGLKYYREYLFWKTYNLLEYRPVTGPQRNPEAPRIPSPAAAAPSPVQPSMLSINHLLQTLLHVLQVTLSFLLMLIFMTYNVWLCLMVVLGAAVGYFLFCWKKSVIVDVTENCH
Protein: Cold shock-like protein CspD (CSP-D) (P0A968)
Organism: Escherichia coli (strain K12)
Function: Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells.
Subcellular location: Cytoplasm.
Interaction partners:
- Uncharacterized protein YchH
- Ribosome modulation factor
- mRNA interferase toxin MqsR
- Antitoxin MqsA
- Universal stress protein F
Sequence:
MEKGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHASVIVPVEVEAAVA
Protein: Holocarboxylase synthetase, isoform C (EC 6.3.4.-, EC 6.3.4.15) (A0A0B4LGM5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Acetyl-CoA carboxylase, isoform A
- Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Pyruvate carboxylase
- GM14617p
- GM13341p)
- NADH-ubiquinone oxidoreductase chain 4
- Trifunctional purine biosynthetic protein adenosine-3
- S-adenosylmethionine synthase
- Adenylosuccinate lyase
- Glutamine-dependent NAD
Sequence:
MLTLYYVSATVLQSWRIQKACSKIAEHLAQPSSIAFYTLQSGSDDGFDPALASSELCCNRNAAKVTDILWLHANQRGCCLRPLQTLHITPWISFPPAPSLLPFSYAADTLTPASTPTEADVPRQQRVSLSAQGEERMQLLLEADIEPLQRPSSEDTSAVRLEDYGKLIAWKIDSHLAVLIETDVEHFTKLLITTFLRNNLCINDQLPLLRIESVQREGDPQPFELLAKHLKRQSRISVGLDKDGWKKHMEDLRAVGVLAHQATEFEYQRNRSEGRTKSDPTTHDQRPTSELLAKAVAVVEPTNKAYLSPARTTEASLKAEAKGTSTKPFPTKSDAKPATLAKSEGTPATSKEDSKLTPTKGALKTSELEKLAAVQAAQQQKKEAVQVSPVKAAFLAKPPMLSKHDEPDKASDQPTKPRKSFEAVKPLNSPPSSRAAPSRPVLQRNKDSLQDAKPLNVLVYSDSASARESTLATLQQLLERNVYTIYPLMPQQAAQKYWTEQTALLVVCGSVAHGIGQILVDYFLQGGKVLSLCSDILHFVLPNYRTAEVREHELVQFSYDKWQRVKMMHHIFCYQPSPVKKHFSTDSEESTKSHSRKPALVCPRSMELKDLAGHSHNLDVHVLGTEETWNTPSLMLAKSLQSGGKAVFSQVHLEMNPSEFESDETKYSILKQNERTRLEIFADLLGKYLDVQVRGGDGVDQPQPGVVYKHAYFLGRHEAKFELLEKLRLRCSGSDNVIATPNLTMKFCGKDDKPPVANNNVLPILIHSCPDDFSTVDYFDNLKTEHIGRLVIYAPVVSSSMHLINNLELIHGLAVLPVQQTSGVGRRNNQWLSPPGCAMFSLQLHLTMDSALSSRLPLLQHLVGTAIVNSLRSHEEYGVLDISIKWPNDIYANGNQKIGGLVINTTLQGSQAIVNIGSGINLNNSRPTVCINDLIREYNTRVPNNKLPILKYELLIAMIFNEIERLLGEVQNGDFDSFYALYYSLWLHSGQSVKICLQKDQEKEAEIVGIDDFGFLEVKLPTGTIEIVQPDGNSFDMLKGLIIPKYQ
Protein: RE39441p (Q7YU48)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLPFRLGLLLGAVLFVASANGAAIENEVSSLNDLQREKRSGRGYSRGQTQSQYLNFGKPEEDGKAEAEATENGSRSTVSGTHGMGQAQSQFSSGDCNGCSGYQTDYPSSGRILDASGSGGIGRPDSIISLPGGVGGQTGAGQAGYGSQLGVGAQAGAGQPGYGDQPGVGTQPGVGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPVVGAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGIGGQTGARQPGYVTQPGVGAQTGIGQPGYGAQPGILGQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGVGAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGVGAQTGAGQPGYGAQPGVGAQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGARQPGYGSQPGVGAQTGAGQPGYGAQPGVGAQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGVGAQTGAGQPGYGAQPGVGAQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGVGAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGVGAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGYGTQPGVGAQTGTGQPGYGAQPGVGGQTGAGQPGYGTQPGIGGQTGAGQPGYGSQPGIGGQTGGGQPGYGSQIGGQTGAGQPSYGSQPGVGAQNGAGQPGYGTQPVIGGQTGAGQPGYGGQTGVGGSPGFLTQPGIGGISGPIGGKLGGGQSEAAKPGYWAQPGIGGPSRYGSQPGIGDQTGTGQSGYGGQPGISGQTGGGQPGYGGQATISGLPGYGTQPGIGALTAVPGGHYGYETQPGIGGQTGTNQPGFGGQPGIGGQTGAGQPGYGFIGQPGIGGQTGTSGRQPGYGTQPGIGGQTAAGQPGYGSQTGVADRSEPDSPDMEANLELADRLEPDNPDTVPNQVLEDNPDTETNLELADRLVPDSPDMEANLELADRPEPDNPDTVPNQVLEDNSDTETNLELADRLEPDSPDMEANLELADRLELDNPDTVSYLDLEDNLE
Protein: Nipped-B protein (Q1XG42)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364107}.
Interaction partners:
Sequence:
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNGRIAEEVNCLLTCRDEPLVSQLIHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQATLARNPNVFREKSLQNRYGVQSGLMMPQYKLPQNSMHGSPASSNYQQTTISHSPSSRFVPPQSSSTSRFIGQQNSPVPSPYAPQSPAGYMPYSHPGSYQQQPQGSVSSPIVAGGLRNLHENKVQQSGSSTNHHADNSRHGTTEDYLQMVQRLGGEDSDSSIRNAASFSLRSPQSVCSPAGSEGTPKGSRPLILQTQPPPYSSPRDAPPDILLDSPDRKQRRPKKLKLSKDEKEQTEKSAMYDIISSPSKDSTKLTLRLTRVRSSEMDQQGDMLSSMENSNISEGDSSFNVQFPGNASKTPVTPQDLSRPLNAAACFQEQTEFLQVQQVPVLQPQTSAAAKPPQPLVAPSQPQQTGSITPYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPLEAGGATGGNRPASQETGSAGNGSRPALMVSIDLQQAGRGDSQATVTQDSDFARKADDIKNCNDGYISGPQEDTVFKHNPENHPMPLRKTESDMECPDKSVKSTTAKLSTESGLEESHKENKLCDIKSEPVECSEETKVSSDCSMETKSESCETDYDDSMMEYKTSEGFNEGIKTEALLNETSNDVKLCDLQDESKENENQSKSSKVDNRLEMRQKLSTPKQKQSDGQPETPRQKFEGKSEALKQKVEVKSEAFKQKTEGKSDTIRQKSEGKPDTPKQKTEGHPETPKQKNESKSETPKQKSESKPETPKQKNDGKPETPKQKSDRSETPKQKSESRPDTPKQKNESRPDTPKQKIEGRQDTPRQKGEGRQEISRQKSEEHKSDGRPETPKHKHDMKKDPNRLSTEKKPDLSKHKTDSKCDSPRVKPESRTDGAKQRVDGRPGHESSKRDGENPKQKHDDKGESEKHKGEMSRLRRPESLRSFNKNDQETRPGSKPDTPKMDKAEKKHRHDSDDSREKHSSGEQKPRPGSPRIKQDGKSTPSKSDPSKSDPSKSKSDKPVLKSPASKDDKRIDVNKSKVEGNKGHSDNKTGFPSYLLGGNQGTLKNFVIPKLKRDKDGNITQESKRSESKGEQKDKPEKMGFVEDLNKGAKPVVVLQKLSLDEVQKLIKERDDKSKGSLKSNKNRPSKSSKGGIDQSVLKELPPELVAEIESSMPLCERVKMNTRKRSTVKEKPKYTEISSGEDEESEETFEPSRKRPKKGKSDADWQYDGDRERRSSGDHRRSGNDSRRGSRYRERSADDSEMEESPPPRLSEVARRLKKERQKKRKAYEPKLTPEELMDSSTFKRFSNAVENILENLEDMDFSAFGDDDEIPQEMLLGKHQLSELGSESAKIKAMGITNKISSEKMVKLLGILEKNIQDGSKLSTMLNHNDTEDEERLWRDLIMERVTKSADACLTAINIMTSPSMPKAVYIEDVIEHVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLMSSKAKRAKCSTHKQRVIVMLYNKICDIVASLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEELFTSLARLPTSKRSLRNFRLNSSDDDGEAMYIQMVTALVLQLIQCVVHLPSDKDHSEEESNKKIDQDVFITNSYETAMRTAQNFLSIFLKKCGSKQAEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSINRILKQAPEGGDDIQQLQKALLDYLEENTETDPSLVFSRKFYIAQWFRDTTMETEKAMKSQKDDDSEGAHHAKEVESTGDIMHRAEKRKKFLRIIIKTAPSQFSTLKSNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLVERILDTGISVRKRVIKILRDICLAQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPAPQNDKEAMTRKIINITDVVAACKDTGYDWFEQLLQNLLKSEEDASYKPVKKACTQLVDNLVEHILKYEESLADSDSKGVNSGRLVSCITTLFLFSKIRPQLMVKHAMTMQPYLTTKCITQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKATQNYKFVWACFNRYYGALLKLKSQHQEDPNSTVLTTNKPALLRSLFTVGALCRHFDFDQEEFKGSSKVNTSVNIKDKVLELLLYFTKHSDEEVQTKAIIGLGFSFIQHPVLMFEVEVKNLYNIILSDKNCSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKMSKQEDLKEMGDISSGMSSSIMQLYLKQVLESFFSTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPSMRNKSDQQLIEIDKKYTGFIHMKAVAGIKMSYQVQQAINSNANQIVRGFRQDESNSALCSHLYSMIRSNRQHRRAFLISLLNLFDDAAKTEVNMLLYIADNLACFPYQSQEEPLFIMHHIDITLSVSGSNLLQSFKESMVMAKQKVKAPSSNEDSSSESDEVSRPKKTRRRGNSESDSDAEDDVEYVLRCLPSNASPLIEFANASQGILLLLMLKQHIKNLCGFSDSKIQKYSPSESAKVYDKAINRKQSVHFHPKQTLEYLKRNMTCTKINDEVKRSIAKQYLDFKMLMEHLDPDEEEEEGEVSASTDARNKAITNLLGGNSPKNNVAETEEEESDGEEKAGGTSGLRKSKRLSDSSDVAVQMNETVDVQDVIAICSPKYKDRPQIAKVVQKTSHGLSIRWMAGSYSGTWAEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVAQTLRSLYAAKDGTSS
Protein: Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) (Q9UPY5)
Organism: Homo sapiens (Human)
Function: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis. In vitro can also transport L-aspartate. May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:15151999, ECO:0000269|PubMed:34880232}; Multi-pass membrane protein {ECO:0000269|PubMed:15151999}. Cell projection, microvillus membrane {ECO:0000269|PubMed:34120018}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the microvillous membrane of the placental syncytiotrophoblast. {ECO:0000269|PubMed:34120018}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A2
- CD44 antigen
- Ubiquitin thioesterase OTUB1
- Beclin-1
- Nuclear factor erythroid 2-related factor 2
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Amino acid transporter heavy chain SLC3A1
- Large neutral amino acids transporter small subunit 1
- Y+L amino acid transporter 2
- Cyclic AMP-dependent transcription factor ATF-4
Sequence:
MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVVPEEDKL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q563W7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQKSWIEHTFTRRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHVGFTATLAVKYSEVSEELSELEQWSVEKHTEESPTDAYGVINFQGGSHSYRAKYVRLSHDSRPEAVLRLMLKEWLMELPKIVISVHGGIQNFELHPRIKQVVGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHLSRSARKICTVGIAPWGVIENRNDLIGRDVVAPYQTLLNPLSKLNVLNNFHSHFLLVDDGTVGKYGAEVRLRRELEKHIQLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILAYVHKQTEQDGALPDGVESDIIATIKKTFNFSHGDALHLFQTLMECMKNKELITVFPVGSEDHQDIDVAILKALLKGTNATAFDQLVLTLAWDRVDIAKDHVFVYGQQLLVGSLEQAMLDALVMDRVEFVKLLIENGVSMHRFLTITRLEELYNTKQTPTNPTLYHLVRDVKQGNLPPNYKITLIDVGLVIEYLMGGTYRCNYTRKRFRIIYNNLHGNSRRSGRHTSSSHSHESFSIQADKKEKTRHNHFIKTAQPYKPRLDSVSELQKKKSKEEVVDVDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEESMAKALVACRLLRSLGDEAKKSDVVDDTSEELKEYSSEFGTLAVDLLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQSMEDSEHNLQHPDDIQMDVFKEVRMSDNAEMKSELEVHVRSRRLPITRKFYAFYHAPIVKFWFNTLFYIGFLMLYSFVVLVKMQDLPSPQEWVVILYIFTLAVEKIREMFMSEGGKISQKIKVWFSDYFNISDFLAILMFFVGFGLRLVSEVFIAGRIVYCLNIIFWYVRLLDILAVNQQAGPYVMMIGKMVANMFYIVVIMAVVLLSFGVPRKAILYPEEEPSWTLAKDVVFQPYWMMYGEVYAYEIDVCANSSEEHVRDLCTTGVWLTPLLQAVYLFVQYILMVNLLIAFFNNVYLQVKSISNLVWKYQRYHFILAYHDKPILPPPLILLSHAASLLSSICRKRKKDSSTYGPKLFLTEEDQKKLHDFEEQCVETYFHEKDDQFHSGSDERIRLTSDRVETMCVQLKEVGNKVNFIKRSLHTLDSQIGHLQDLSALTVDTLKALTAQRASEASKVHNQITRELSVSRNLAPEAVPPSKPGALVRCSVAFMPPNSMADSLFGGGVEAVQGAGLPHASLTADGVQTPQMRRRGHQEHLSSAPAAAASFFLSTPLPQQQDLQAPPEEFGAFVGHKDEPEGQRSIPKESAVSSPSRKTRDVGNMRTVNSYAGFTELDRNPSLLHPESTLSKQERTRVSLEDVSRYEDLLLGKSAQSSKLSPGDDASNTAIGSPFKPMESYQYSAVERNNLMRLSQSIPFTPVPPRGEPVSVYRLEESSPGSINNSMSSWAQRGLCAKIEFLSKEEMGGGLRRALKVLCTWSEYDILKPGHLYIVKSFLPEVVNTWQTIYREETVLHLCLREIQQQRAAQKLTFAFNQIRPKTIPYSPRFLEVFLLYCHSAGQWFAIEECITGDFRKFNNNNGDEIVPTNLLEETMLAFSHWTYEYTRGELLVLDLQGVGEILTDPSVIKSGEKGSYDMIFGPANLGDDAIRNFRAKHHCNSCCRKLKLPDLKRNDYTPDKLTLQHDPSEGPSHSPPAGAATKELRPSMRLML
Protein: LD44990p (Q86NY8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
TLLSGSAAATAAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSSTTDSPDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQRLLSVPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSRSSSMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPERDVRKSQPVLITINGGPVVRLKGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDVANQCCINRIQLSEMDFAVKAETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSIWGQQIIVHEDTTQISKIFCFSHKGHGLYMASPTEIQKFTISSEFCQFILEMMGELYTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQSGKPNRSVARHIPGPNLEQLGQRASTAASEISRAHQLAMERGEKLNLLEERAERMANTAQDFSGTAHQLMLKYKDKKWYQL
Protein: Dynamin associated protein 160, isoform H (M9PDC7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQTSFEDKRKENYVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSGNV