Protein: Transcriptional regulator ovo (Transcriptional repressor shavenbaby) (Transcriptional repressor svb) [Cleaved into: Transcriptional activator shavenbaby (Transcriptional activator svb)] (P51521)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcriptional regulator with essential functions in the germline and soma. Plays an essential role in regulating the formation of apical cell extensions such as denticles and aristae, and initiating cytoskeletal remodeling during epidermal differentiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1712294, ECO:0000269|PubMed:7935398, ECO:0000269|PubMed:9012532}. Nucleus {ECO:0000269|PubMed:1712294, ECO:0000269|PubMed:7748792, ECO:0000269|PubMed:7935398}.; SUBCELLULAR LOCATION: [Transcriptional activator shavenbaby]: Nucleus, nucleoplasm {ECO:0000269|PubMed:20647469}. Note=Diffuse nucleoplasmic distribution. {ECO:0000269|PubMed:20647469}.; SUBCELLULAR LOCATION: [Isoform B]: Nucleus {ECO:0000269|PubMed:20647469, ECO:0000269|PubMed:25344753, ECO:0000269|PubMed:26383956}. Note=Localizes to the nuclear foci. {ECO:0000269|PubMed:20647469}.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus {ECO:0000269|PubMed:20647469, ECO:0000269|PubMed:26383956}. Note=Localizes to the nuclear foci. {ECO:0000269|PubMed:20647469}.; SUBCELLULAR LOCATION: [Isoform D]: Cytoplasm {ECO:0000269|PubMed:7748792}. Nucleus {ECO:0000269|PubMed:26383956, ECO:0000269|PubMed:9012532}. Nucleus, nucleoplasm {ECO:0000303|PubMed:20647469}. Note=Diffuse nucleoplasmic distribution (PubMed:20647469). Expressed in germ cell nuclei throughout oocyte development (PubMed:7748792). Not expressed in nuclei of stage 9 oocytes but is expressed in nurse cell nuclei (PubMed:7748792). In stage 12 oocytes it is also detected in the ooplasm (PubMed:7748792). {ECO:0000269|PubMed:20647469, ECO:0000269|PubMed:7748792}.
Interaction partners:
- Peptide tarsal-less AA
- E3 ubiquitin-protein ligase Ubr3
- Uncharacterized protein, isoform B
- Shaven, isoform A
- Shavenoid, isoform B
Sequence:
MPKIFLIKNRLHQQQQRLLESQNLLQHKNQDDERLVPPLSPSGSGSGPSPTPTSQPPPEPQGQGQQVLGQVPDSDQQPLSLTRKRFHHRRHYFGQSRHSLDHLNQNQSPNPNANANPNQIQNPAELEVECATGQVQNENFAAELLQRLTPNTATTAQNNIVNNLVNNSRAATSVLATKDCTIENSPISIPKNQRAEDEEEQEDQEKEKPAEREREKSDERTEQVEKEERVEREEEEDDEVDVGVEAPRPRFYNTGVVLTQAQRKEYPQEPKDLSLTIAKSSPASPHIHSDSESDSDSDGGCKLIVDEKPPLPVIKPLSLRLRSTPPPADQRPSPPPPRDPAPAVRCSVIQRAPQSQLPTSRAGFLLPPLDQLGPEQQEPIDYHVPKRRSPSYDSDEELNARRLERARQVREARRRSTILAARVLLAQSQRLNPRLVRSLPGILAAAAGHGRNSSSSSGAAGQGFQSSGFGSQNSGSGSSSGNQNAGSGAGSPGSGAGGGGGMGGGRDGRGNYGPNSPPTGALPPFYESLKSGQQSTASNNTGQSPGANHSHFNANPANFLQNAAAAAYIMSAGSGGGGCTGNGGGGASGPGGGPSANSGGGGGGGGGNGYINCGGVGGPNNSLDGNNLLNFASVSNYNESNSKFHNHHHHHQHNNNNNNNGGQTSMMGHPFYGGNPSAYGIILKDEPDIEYDEAKIDIGTFAQNIIQATMGSSGQFNASAYEDAIMSDLASSGQCPNGAVDPLQFTATLMLSSQTDHLLEQLSDAVDLSSFLQRSCVDDEESTSPRQDFELVSTPSLTPDSVTPVEQHNTNTTQLDVLHENLLTQLTHNIVRGGSNQQQQHHQQHGVQQQQQQQHSVQQQQQHNVQQQHGVQQQHVQQQPPPSYQHATRGLMMQQQPQHGGYQQQAAIMSQQQQQLLSQQQQQSHHQQQQQQQHAAAYQQHNIYAQQQQQQQQQHHQQQQQQQHHHFHHQQQQQPQPQSHHSHHHGHGHDNSNMSLPSPTAAAAAAAAAAAAAAAAAAHLQRPMSSSSSSGGTNSSNSSGGSSNSPLLDANAAAAAAAALLDTKPLIQSLGLPPDLQLEFVNGGHGIKNPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHSNSSASSNASSHGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKMYVCEECGHTTCEPEVHYLHLKNNHPFSPALLKFYDKRHFKFTNSQFANNLLGQLPMPVHN