wanglab/gogpt-training-data huggingface dataset:
Protein: Regulator of chromosome condensation 1 (C9J3R0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRHCLFHTSQRLGWGKEVWRQGLSHLRVSKDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGS
Protein: Solute carrier family 22 member 7 isoform X2 (Solute carrier family 22 member 7b, tandem duplicate 3) (F1QS93)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKFEDLITEINGFGRFQKMILCISFVGRFIIPCHFLLSNFIAAIPSHHCDISFLDADGLFGNLTEEERLIVSVPTQEDGSPVSCHMFSHPQFQLLINSSSSSDLPVVECQNGWHFDNSTFISTLATQWDLVCDNRGLNKAVATIFFVGVMFGAAFFGGMSDRFGRKPMLLVSYISGMAFALASVFSTSFTMFAVLRFFSGFTITGIVIVSSVLNLEWVDIEHRRLVSIIDSMAWAVGSTSLALIAYFIRDWRWLTVAVTSPLVLCTILWWWVPESARWLIANGDVEKAHYYLHKCAVMNRKAEVTSRIKPEALAISVSDQGKKKYTYLDLVRTPKMRKLAMLTGTVWFCVATMTYGISLNITGFGLNMYLTQFVYGAIEVPSKLIVYYLLEKIGRRKTEAGAQLFAGISLMINIFIPKDQWIGRTVVAVLGKGFAVAAFCTIVLYSSELYPTVLRQNGMGYNSFLARLGVSVAPLVLLLDTFWGQFSQTILCSVALIASVVAWNLPETRDRCLPETIEDVEGTGKTPNKDQEKQENEEKIAMNEPQ
Protein: Far upstream element binding protein 3 (A0A8I6G4A0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAELVQGQSAPVGLKAEDFVDALHRVRQIAAKIDSIPHLNNSTPLVDPSVYGYGVQKRPLDDGGKLLAVITEEFKVPDKMVGFIIGRGGEQISRIQAESGCKIQIASESSGIPERPCVLTGTPESIEQAKRLLGQIVDRCRNGPGFHNDIDGNSTIQELLIPASKVGLVIGKGGETIKQLQERTGVKMVMIQDGPLPTGADKPLRITGDPFKVQQAREMVLEIIREKDQADFRGVRSDFTSRAGGGSIEVSVPRFVVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGISPERAAQVMGPPDRCQHAARIINELILTAQEREILGGLTGTRGRGRGRGDWSVGTPGGIQEITYTVPADKCGLVIGKGGENIKSINQQSGAHVELQRNPPPNTDPNLRIFTIRGAPQQIEVARHLIDEKVGGASLGAPTAFGQSPFSQPPAAPHQNTFPPRAFPNIAAKVNGNPHSTPVSGPPAFLTQGWGSTYQAWQQPTQQVPSQQSQPQNSQPDYSKAWEDYYKKQGHTTSAAPQASSPPDYTMAWAEYYRQQAAFYGQTLGQAQAHSQVCSQSPAP
Protein: Dibasic-processing endoprotease (EC 3.4.21.-) (KEX2-related protease) (Q09175)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Membrane-bound, subtilisin-like serine protease that processes the P-factor precursor and other precursor proteins. Essential for cell viability. Cleaves substrate on the C-terminal side of dibasic residues.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16823372}; Single-pass type I membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pheromone-processing carboxypeptidase kex1
- Aspartic proteinase yapsin-1
- Calnexin homolog
- Pro-P-factor
- Inositol polyphosphate multikinase
Sequence:
MHPALLCGPILAIFLQFLVSSCSPLENDDLFLVQVEPEVDPVVAAEAIGAKYVRPLLNLKYHHLIKLHKGSDDSVQSSIRKRGIDAGILELERQTPRWRYKRDASESDELLNEFSNHFGISDPLFYGQWHIFNSNNPGHDLNLREVWDAGYFGENVTVAFVDDGIDFKHPDLQAAYTSLGSWDFNDNIADPLPKLSDDQHGTRCAGEVAAAWNDVCGVGIAPRAKVAGLRILSAPITDAVESEALNYGFQTNHIYSCSWGPADDGRAMDAPNTATRRALMNGVLNGRNGLGSIFVFASGNGGHYHDNCNFDGYTNSIFSATIGAVDAEHKIPFYSEVCAAQLVSAYSSGSHLSILTTNPEGTCTRSHGGTSAAAPLASAVYALALSIRPDLSWRDIQHITVYSASPFDSPSQNAEWQKTPAGFQFSHHFGFGKLDASKFVEVAKDWQVVNPQTWLIAPEINVNKSFGSVNNETITEMVSEFTVTKDMIEKSNFKRLEHVTVRVCIPFNRRGALEILLESPSGIRSILASERPYDENSKGFLDWTFMTVQHWAEPPEGVWKLLVNDRSGGKHEGTFENWQLALWGESENPSNTAPLPYDTLELPKEMVLGIYSEPNSDLTNSSTLLSPTSTSFTSYTVSATATPTSTSHIPIPTVLPPTQPVLEPSYREIVAFITFFLLFAFIFVAVIWTWISAFWKAKAPPPLSQQEIA
Protein: Bromodomain-containing protein 3 (RING3-like protein) (Q15059)
Organism: Homo sapiens (Human)
Function: Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:18406326}. Note=Detected on chromatin. {ECO:0000269|PubMed:18406326}.
Interaction partners:
- Bromodomain-containing protein 2
- Erythroid transcription factor
- Histone-lysine N-methyltransferase NSD3
- Bromodomain-containing protein 4
- Histone H4
- Histone-lysine N-methyltransferase NSD2
- Bromodomain testis-specific protein
- Speckle-type POZ protein
- HLA class II histocompatibility antigen, DM alpha chain
- Histone H4-like protein type G
Sequence:
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
Protein: Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (CACT) (mCAC) (Solute carrier family 25 member 20) (Q9Z2Z6)
Organism: Mus musculus (Mouse)
Function: Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism. Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation. Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Carnitine O-palmitoyltransferase 2, mitochondrial
- Carnitine O-acetyltransferase
- Mitochondrial basic amino acids transporter
- Gamma-secretase subunit APH-1A
- Carnitine O-palmitoyltransferase 1, liver isoform
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Carnitine O-palmitoyltransferase 1, muscle isoform
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
- Palmitoyl thioesterase CPT1C
Sequence:
MADEPKPISPFKNLLAGGFGGMCLVFVGHPLDTVKVRLQTQPPSLSGQPPMYSGTLDCFRKTLMREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKSPEDELSYPQLFTAGMLSGVFTTGIMTPGERIKCLLQIQASSGENKYSGTLDCAKKLYQEFGIRGFYKGTVLTLMRDVPASGMYFMTYEWLKNLFTPEGKSVSDLSVPRILVAGGFAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIREEGVTSLYKGFNAVMIRAFPANAACFLGFEIAMKFLNWIAPNL
Protein: RNase H domain-containing protein (RNase H family protein) (F4I7R5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 6
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 2
- Mitotic spindle checkpoint protein MAD2
- Ubiquitin-conjugating enzyme E2 22
- Anaphase-promoting complex subunit 7
Sequence:
MNCLSHARSYIALGLLKRSSYVSSIPWNECFFYMPSKSCLKPVAVSSVFGICSVHSYSSRSKAVKSKMLSSTVVSAVDKEKDAFFVVRKGDVIGIYKDLSDCQAQVGSSVFDLPVSVYKGYSLPKDTEEYLSSVGLKKPLYSLRASDLKDDMFGALTPCLFQEPAPCTVKVSEDETTSETKSKDDKKDQLPSASISYDPLEKLSKVEPSAYISDETCFIEFDGASKGNPGLSGAAAVLKTEDGSLICRVRQGLGIATNNAAEYHALILGLKYAIEKGYKNIKVKGDSKLVCMQIKGQWKVNHEVLAKLHKEAKLLCNKCVSFEISHVLRNLNADADEQANLAVRLPEGEVEVA
Protein: RAS guanyl releasing protein 4 variant 9 (C0LTP6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRGEWGVSEWEGSLGPQAGRMDDTDRTPAAAFPQSAGCVATNTAETR
Protein: Ribosome-recycling factor (RRF) (Ribosome-releasing factor) (P9WGY1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00040}.
Interaction partners:
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein bL27
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL11
Sequence:
MIDEALFDAEEKMEKAVAVARDDLSTIRTGRANPGMFSRITIDYYGAATPITQLASINVPEARLVVIKPYEANQLRAIETAIRNSDLGVNPTNDGALIRVAVPQLTEERRRELVKQAKHKGEEAKVSVRNIRRKAMEELHRIRKEGEAGEDEVGRAEKDLDKTTHQYVTQIDELVKHKEGELLEV
Protein: Uncharacterized protein (Q38EE1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCNHQQPDPHFPSSVISSIPSIFYLLKELVTSVVEAHMSGTPTRKNLVASGASSARRAAHTGVNQTTEHRRSSIKTDGKRSTPSKGSHIGNERKSNRSNSGDRKSNRSNSGDRKSNRRNPTPEPNGSLENMSTSQLLSRLLCNTRLEDMRPDAYRLDMTQKEDVRYLYEMQHRVDPELNPFRARANTAKINQMNKSRIFDFTSPTPSVRKQPAVKHDDGLGSLARFIYSQEGRRKTTPLGRRPNTVAQRRATFHPFRPDEQEYNPITPGRRVRYQLSTYRWDNLGGNLVVKERSSAATTPRPCIRTRKGVDAFEATQPVHTLPPRKRPPRVTESMQGHPGYLDHDIFGIRSRRKEATQRCRSLSPFLVGRTDLDVRRTAVSQSATPLYSPRNNYPAAAGVTSTPDRRHCTTPFGDESPAEVGPRGLSSSREPIHFSEGEDNRDGRQCVCTANTPTKGDISATSAPGGGDNFYDPAGVLVSPRIRSGVGRVAGQHVTKSNIVFGETYQPQTPSPRRVSYHTSHLNSTQVRDLLVWT
Protein: Photosystem II reaction center protein L (PSII-L) (Q2LIK0)
Organism: Oryza rhizomatis
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01317}.
Interaction partners:
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: Ectonucleoside triphosphate diphosphohydrolase 2 a.1 (Ectonucleoside triphosphate diphosphohydrolase 2a.1) (Q66L64)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVSTGNRQQCQIITATGALFLAVGGILLLVLPSEDIKGSPGFMYGIVLDAGSSHTSMFIYKWPADKQNGTGIVSQHSECHAKGGGISSYAGVKGGAARSLKECMDKAMREIPTVRYKHTPVYLGATAGMRLLNISKPKESAEVLKEVEEKLKSYPFSFKGASILTGQEEGAYGWITVNYLLENYIKYGFVGQWITPGRDTVGALDFGGASTQITFVTKQTVENKDDLMKLRLYGRDYQIYTHSFLCYGRDQVLLRLLAHLITIQGSDTSIIHPCYPADYSSSIKLSSVFGTPCVEKQTSYNPDGELQIKGTGNYNQCLGNVSQLFSFSSCSYSKCSFDGVFQPNITGNFMAFSAFFYTHSFLQEATGIKIWTPAHLEDAARVICNMSLQEMGKKSQDNESRLKDYCAVSVFVRALLVNGYSFNDRTFPQISFQKKAGDTSVGWSLGYMLSLSNLLPAENVALKKSLRSGAWSFLIFLFSILLTSALIFLFRAICHKNKDDVV
Protein: Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) (O14544)
Organism: Homo sapiens (Human)
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Interaction partners:
- Elongin-C
- Elongin-B
- Cullin-5
- Tyrosine-protein kinase JAK2
- Suppressor of cytokine signaling 5
- Epidermal growth factor receptor
- Mast/stem cell growth factor receptor Kit
- Signal transducer and activator of transcription 3
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Signal transducer and activator of transcription 5B
Sequence:
MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
Protein: RE14068p (Q8SY14)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MKLWKSKKPIGGCVPGKSAALKQDQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDCLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQRSE
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (P80566)
Organism: Gallus gallus (Chicken)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
- Superoxide dismutase
- Copper chaperone for superoxide dismutase.
- Protein/nucleic acid deglycase DJ-1
- TAR DNA-binding protein 43
- Catalase
- C9orf72-SMCR8 complex subunit.
- RRM domain-containing protein.
- Thioredoxin
- Glutathione peroxidase
- Glutathione peroxidase
Sequence:
MATLKAVCVMKGDAPVEGVIHFQQQGSGPVKVTGKITGLSDGDHGFHVHEFGDNTNGCTSAGAHFNPEGKQHGGPKDADRHVGDLGNVTAKGGVAEVEIEDSVISLTGPHCIIGRTMVVHAKSDDLGRGGDNESKLTGNAGPRLACGVIGIAKC
Protein: Transportin-2 (Karyopherin beta-2b) (Q99LG2)
Organism: Mus musculus (Mouse)
Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 14
- GTP-binding nuclear protein Ran
- Importin-7
- Importin-4
- Importin-13
- Nuclear pore complex protein Nup98-Nup96
- Transportin-3
- Importin-8
- Importin-11
Sequence:
MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLTHEAERPDSSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPLLKERLAAFYGV
Protein: Protein GPR108 (Lung seven transmembrane receptor 2) (Q9NPR9)
Organism: Homo sapiens (Human)
Function: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q91WD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:31784416}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus membrane {ECO:0000269|PubMed:32280726}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TLR3, -7, -4, and -9. {ECO:0000250|UniProtKB:Q91WD0}.
Interaction partners:
- Secretory carrier-associated membrane protein 2
Sequence:
MAVSERRGLGRGSPAEWGQRLLLVLLLGGCSGRIHQLALTGEKRADIQLNSFGFYTNGSLEVELSVLRLGLREAEEKSLLVGFSLSRVRSGRVRSYSTRDFQDCPLQKNSSSFLVLFLINTKDLQVQVRKYGEQKTLFIFPGLLPEAPSKPGLPKPQATVPRKVDGGGTSAASKPKSTPAVIQGPSGKDKDLVLGLSHLNNSYNFSFHVVIGSQAEEGQYSLNFHNCNNSVPGKEHPFDITVMIREKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFHSINYYFINSQGHPIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQVLANVAYIIIESREEGASDYVLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLAKLKLFRHYYVMVICYVYFTRIIAILLQVAVPFQWQWLYQLLVEGSTLAFFVLTGYKFQPTGNNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL
Protein: Bacteriocin rhamnosin A (P86526)
Organism: Lacticaseibacillus rhamnosus (Lactobacillus rhamnosus)
Function: Antibacterial activity against the Gram-positive bacterium M.lysodeikticus. It may act as a pore-forming protein, creating a channel in the cell membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:19796123}.
Interaction partners:
Sequence:
AVPAVRKTNETLD
Protein: SHC-transforming protein homolog 1 (Src homology 2 domain adapter homolog 1) (Q9TYT3)
Organism: Caenorhabditis elegans
Function: Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Plays a role in maintaining gonadal basement membrane integrity through activation of the JNK pathway components mek-1 and jnk-1. Involved in the response to several environmental stresses including heavy metal ions (Cu(2+) and Cd(2+)), heat, oxidative and protein misfolding (ER) stresses. Plays a role in gonad and germline development following the L1 diapause. Plays a role in life span and egg laying. Plays a role in axon regeneration after injury.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18832074}. Nucleus {ECO:0000269|PubMed:18832074}. Cell membrane {ECO:0000269|PubMed:18832074}; Peripheral membrane protein {ECO:0000269|PubMed:18832074}. Note=In intestinal cells, enriched in the nucleus. {ECO:0000269|PubMed:18832074}.
Interaction partners:
- Sex muscle abnormal protein 5
- Receptor tyrosine-protein kinase let-23
- Son of sevenless homolog
- Dual specificity mitogen-activated protein kinase kinase mek-1
- Protein nipi-4
- Insulin-like receptor
- Tyrosine-protein kinase receptor svh-2
- Mitogen-activated protein kinase kinase kinase mlk-1
Sequence:
MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDIE
Protein: Galectin (I2HAG1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFRRRSKSLAVTEPTTNGTVKKKRGHGTTVRLPVYLREIIMAEPKSFNIPYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSPDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAKNPIKKGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQWGGKYYPVPYESGIAADGLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKANGFMCAKPTPGSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQVVNNQPAQE
Protein: Anthrax toxin receptor (A0A8I6A282)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MVAGRSRARSPGSWLFPGLWLLTVGGPGSLLQAQEQPSCKKAFDLYFVLDKSGSVANNWIEIYNFVHQLTERFVSPEMRLSFIVFSSQATIILPLTGDRYKISKGLEDLKAVQPVGETYIHEGLKLANEQIQNAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKKSRSLGASVYCVGVLDFEQAQLERIADSKDQVFPVKGGFQALKGIINSILAQSCTEILELSPSSVCVGETFQVVLSGRAVMSIRDDGSVLCTFTANSTYTKNEKPVSVQPGSILCPAPVLNKAGETLEVSIAFNDGKSAVSRSLTITATECSNGIAAIIAILVLLLLLGAALMWWFWPLCCKVVIKDPPPPPSPPKEEEEEEPLPNKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVMIPEEEIPVPSRPPRPKPTHQAPQTKWYTPIKGRLDALWALILKQYDRVSLMRPQEGDEVRDFLRKLVGGGAYNGSNLKLPVSMWGRIDADGYTFLLHWVLV
Protein: Clathrin light chain (dClc) (Q9VWA1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Interaction partners:
- Clathrin heavy chain
- Huntingtin interacting protein 1
- Cyclin-G-associated kinase
- AP complex subunit beta
- AP-2 complex subunit alpha
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- AP complex subunit sigma
- Adaptor protein complex 2, mu subunit, isoform A
- FI19443p1
- Adaptor protein complex 1, mu subunit
Sequence:
MDFGDDFAAKEDVDPAAEFLAREQSALGDLEAEITGGSASAPPAASTDEGLGELLGGTASEGDLLSAGGTGGLESSTGSFEVIGGESNEPVGISGPPPSREEPEKIRKWREEQKQRLEEKDIEEERKKEELRQQSKKELDDWLRQIGESISKTKLASRNAEKQAATLENGTIEPGTEWERIAKLCDFNPKVNKAGKDVSRMRSIYLHLKQNPIQVQKST
Protein: Methyl-CpG binding domain protein-like, isoform B (Methyl-CpG binding domain-like protein) (Q9V424)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT