wanglab/gogpt-training-data huggingface dataset:
Protein: Coproheme decarboxylase (EC 1.3.98.5) (Coproheme III oxidative decarboxylase) (Hydrogen peroxide-dependent heme synthase) (Iron-coproporphyrin oxidative decarboxylase) (P9WL45)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate (By similarity).
Interaction partners:
- Coproporphyrin III ferrochelatase
- Coproporphyrinogen III oxidase
- Uroporphyrinogen decarboxylase
- Aspartyl/glutamyl-tRNA
- Conserved protein
- Glycine--tRNA ligase
- Energy-dependent translational throttle protein EttA
- Probable enoyl-CoA hydratase EchA15
- Methyltransferase domain-containing protein
Sequence:
MARLDYDALNATLRYLMFSVFSVSPGALGDQRDAIIDDASTFFKQQEERGVVVRGLYDVAGLRADADFMVWTHAERVEALQATYADFRRTTTLGRACTPVWSGVGLHRPAEFNKSHIPAFLAGEEPGAYICVYPFVRSYEWYLLPDEERRRMLAEHGMAARGYKDVRANTVPAFALGDYEWILAFEAPELDRIVDLMRELRATDARRHTRAETPFFTGPRVPVEQLVHSLP
Protein: Protein UL79 (Q6SW63)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the expression of late transcripts bridging viral DNA replication and late gene expression during infection. Functions concordantly with UL87 to initiate transcription from over half of all active viral promoters in late infection, without affecting host transcription. Acts on and binds to viral early-late and late kinetic-class promoters.
Subcellular location: Host nucleus {ECO:0000250|UniProtKB:P16752}. Note=Localizes in replication compartments during virus infection. {ECO:0000250|UniProtKB:P16752}.
Interaction partners:
Sequence:
MMARDEENPAVPRVRTGKFSFTCANHLILQISEKMSRGQPLSSLRLEELKIVRLICVLLFHRGLETLLLRETMNNLGVSDHAVLSRKTPQPYWPHLYRELRQAFPGLDFEAAVFDETRAARLSQRLCHPRLSGGLLTRFVQRHTGLPVVFPEDLARNGNILFSLGTLYGHRLFRLAAFFTRHWGAEAYEPLIRIICQKMWYFYLIGTGKMRITPDAFDIQRSRHETGIFTFIMEDYRTFAGTLSRHPHRPHPQQQQHHHPGPPHPPLSHPASSCLSPEAVLAARALHMPTLANDV
Protein: Nucleolar GTP-binding protein 1 (Q9C6I8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- 60S ribosomal export protein NMD3
- Probable ribosome biogenesis protein RLP24
- Pescadillo homolog
- Nuclear/nucleolar GTPase 2
- Ribosome production factor 2 homolog
- Ribosome biogenesis protein BOP1 homolog
- Ribosome assembly factor mrt4
- Protein MAK16 homolog
- Ribosome biogenesis protein WDR12 homolog
- AT5g04600/T32M21_200
Sequence:
MVQYNFKRITVVPNGKEFVDIILSRTQRQTPTVVHKGYKINRLRQFYMRKVKYTQTNFHAKLSAIIDEFPRLEQIHPFYGDLLHVLYNKDHYKLALGQVNTARNLISKISKDYVKLLKYGDSLYRCKCLKVAALGRMCTVLKRITPSLAYLEQIRQHMARLPSIDPNTRTVLICGYPNVGKSSFMNKVTRADVDVQPYAFTTKSLFVGHTDYKYLRYQVIDTPGILDRPFEDRNIIEMCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIKSLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAMKTAMGASEEQVLLKMSTLTDEGVMSVKNAACERLLDQRVEAKMKSKKINDHLNRFHVAIPKPRDSIERLPCIPQVVLEAKAKEAAAMEKRKTEKDLEEENGGAGVYSASLKKNYILQHDEWKEDIMPEILDGHNVADFIDPDILQRLAELEREEGIREAGVEEADMEMDIEKLSDEQLKQLSEIRKKKAILIKNHRLKKTVAQNRSTVPRKFDKDKKYTTKRMGRELSAMGLDPSSAMDRARSKSRGRKRDRSEDAGNDAMDVDDEQQSNKKQRVRSKSRAMSISRSQSRPPAHEVVPGEGFKDSTQKLSAIKISNKSHKKRDKNARRGEADRVIPTLRPKHLFSGKRGKGKTDRR
Protein: WD repeat-containing protein ATCSA-1 (Cockayne syndrome WD repeat protein CSA homolog) (Q93ZG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in UV-B tolerance and genome integrity. In association with DDB2, is necessary for repair of UV-B-induced DNA lesions.
Subcellular location: Nucleus {ECO:0000269|PubMed:20128879}. Note=Localizes in a speckled pattern. {ECO:0000269|PubMed:20128879}.
Interaction partners:
- DNA damage-binding protein 1a
- Protein DAMAGED DNA-BINDING 2
- Cullin-4
- DNA damage-binding protein 1b
- Protein CHROMATIN REMODELING 8
- WD repeat-containing protein RUP2
- UV-stimulated scaffold protein A homolog
- Switch 2
- Protein CHROMATIN REMODELING 24
- WD repeat-containing protein RUP1
Sequence:
MWEAIKDRETGRIRSNSFANRFKSRRILSLQLSNRKDFVSPHRGSVNSLQVDLTEGRYLLSGAADGSAAVFDVQRATDYEASGLIAKHKCIFTVDKQHENGHKYAISSAIWYPIDTGLFITGSFDHYLKVWDTNTAQAVVDFKMPGKVYRTAMSSMAMSHTLIAAGTEDVQVRLCDIASGAFSHTLSGHRDGVMSVEWSTSSEWVLYTGGCDGAIRFWDIRRAGCFRVLDQSQTQLGFRPPILKRTAVGSKLSSVAKSSLGGQNRLKTLQSKQTGSQSVKGSSSAKASVEKSRQKRIHPGMLSTLDRATAHYGAVTGLKATNDGMYLLSAGSDSRIRLWDIESGRNTLVNFETGRIQTNKGIQLDTSDDPALVFVPCMKTVKAFGMWSGRTTLMLRGHYESVNTCCFNSNDQELYTSGSDRQILVWSPGGTVEDEMVQDEVAEDKDNWSD
Protein: Phosphatase, putative (Q382E9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRDPPGEGGESSPVCADMSIDKFSILTPEKQTFKKKDQSKVDGFLDRMRQRIHCTFCGGAKCKHENWESLKEKRYKTAIEGLISSWVGDDVIASQRPSTSLFRKYSLIEQFREKRITGVLNLQEKGEHASCGPDGIYASTGYSYSGEQDLMRHQISYYEFPWPDMTAPKQDIVLRSVQVMDSHVKKSGKVLVHCHAGLGRTGLMIACYLLYAQKMPSADVIELVRQMRPGAIQTSRQVKFIHDFESHLWRLSHTFRVEVSESALDIDLFLKKQRLLLHGDHADSYRFIPMTIHLILCQLLNLTKANPSNSELSVKSLGSGRLPEGSALNDVRRSINRRTFDATSVNDVKLLSYLVWDWFKSLSFPVLTPDEASAIVAYMRQPPGERIALPTFIRTTLRLSVVQTLGMVLSAYHIICLNIKESLKVRALRCLTDSFTTVRDGVTVRGEPGTFGLLYEFFVDWARLDQGGCFDLGGAGYQDHTISGIAEESADVL
Protein: thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Q9GPQ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAHSVDALNSHVDWVNDIKSYCLDIPGDFPYPIIADPTRDLAVSLGMLDEEQKKDPEVGKTIRALFIISPDHKVRLSMFYPMSTGRNVDEILRTIDSLQLTDRLKVVATPANWTPGTKVMILPTVTDDEAHKLFPKGFDKVSMPSGVNYVRTTDNY
Protein: L-3-cyanoalanine synthase 1, mitochondrial (MdCAS1) (EC 4.4.1.9) (Q1KLZ2)
Organism: Malus domestica (Apple) (Pyrus malus)
Function: Probably involved in the detoxification of cyanide that arises from ethylen biosynthesis in ripening fruits. Has only background level of in vitro cysteine synthase activity.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
Sequence:
MAALRSFLKKRSSVLCNGAMRRKLFSTEVSQPLTDSPSFAQRIRNLPKDLPGTQIKTQVSQLIGRTPIVYLNKVTEGCGAYIAVKQEMFQPTASIKDRPALSMINDAEEKGLITPGETILIEPTSGNMGISMAFMAAMRGYKMVLTMPSYTSLERRVCMRCFGADLILTDPTKGMGGTVKKAYDLLESTPNAYMLQQFSNPANTKVHFETTGPEIWEDTNGQVDIFVMGIGSGGTVSGVGQYLKSKNPNVQIYGVEPAESNVLNGGKPGPHSIMGNGVGFKPDILDLDMLERVIEVTSEDAVNMARQLALKEGLMVGISSGANTVAAMELAKKPENKGKLIVTVHPSFGERYLSSVLFQELRQEAENMQPVAVDYP
Protein: Large ribosomal subunit protein bL19 (50S ribosomal protein L19) (P9WHC9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Interaction partners:
- Small ribosomal subunit protein bS18A
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein bL34
- Small ribosomal subunit protein bS6
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS7
Sequence:
MNRLDFVDKPSLRDDIPAFNPGDTINVHVKVIEGAKERLQVFKGVVIRRQGGGIRETFTVRKESYGVGVERTFPVHSPNIDHIEVVTRGDVRRAKLYYLRELRGKKAKIKEKR
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) (O75173)
Organism: Homo sapiens (Human)
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- Brevican core protein
- Collagenase 3
- Stromelysin-1
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Fibronectin
- Metalloproteinase inhibitor 3
- Metalloproteinase inhibitor 1
Sequence:
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
Protein: Vesicle transport protein (Q2HIG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363111}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363111}.
Interaction partners:
- Vesicle transport protein GOT1
- Trafficking protein particle complex subunit
- Peroxisome biogenesis protein 3-1
- Pentatricopeptide repeat-containing protein At1g15510, chloroplastic
- WRKY transcription factor-like protein
- Serine carboxypeptidase-like 33
Sequence:
MSQGWFSMGGSSTVDQQQQSGSSLLADWNSYAASRDFEESGGSFGFDIESAVRSANDTVSGTFSVVSKGVRDIPGSLQSATSSMPSGKALMYFGLLLASGVFFIFIAFTMFLPVMVLMPQKFAICFTLGCGFIIGSFFALRGPKNQLAHMSSMERLPSTLGFIATMVGTIYVSMVLHSYILSVLFSVLQVLALVYYCISYFPGGSSGMRFLSSALTSSALRVFGR
Protein: Prolactin (PRL) (P01237)
Organism: Rattus norvegicus (Rat)
Function: Prolactin acts primarily on the mammary gland by promoting lactation.
Subcellular location: Secreted.
Interaction partners:
- Prolactin receptor
- Somatotropin
- Leptin
- Glycoprotein hormones alpha chain
- Pro-opiomelanocortin
- Erythropoietin
- Tyrosine-protein kinase JAK2
- Thrombopoietin
- Granulocyte colony-stimulating factor
- Ciliary neurotrophic factor
Sequence:
MNSQVSARKAGTLLLLMMSNLLFCQNVQTLPVCSGGDCQTPLPELFDRVVMLSHYIHTLYTDMFIEFDKQYVQDREFIAKAINDCPTSSLATPEDKEQAQKVPPEVLLNLILSLVHSWNDPLFQLITGLGGIHEAPDAIISRAKEIEEQNKRLLEGIEKIISQAYPEAKGNEIYLVWSQLPSLQGVDEESKDLAFYNNIRCLRRDSHKVDNYLKFLRCQIVHKNNC
Protein: Taste receptor type 2 member 7 (T2R7) (Taste receptor family B member 4) (TRB4) (Q9NYW3)
Organism: Homo sapiens (Human)
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 1 member 3
- Taste receptor type 1 member 2
- Taste receptor type 1 member 1
Sequence:
MADKVQTTLLFLAVGEFSVGILGNAFIGLVNCMDWVKKRKIASIDLILTSLAISRICLLCVILLDCFILVLYPDVYATGKEMRIIDFFWTLTNHLSIWFATCLSIYYFFKIGNFFHPLFLWMKWRIDRVISWILLGCVVLSVFISLPATENLNADFRFCVKAKRKTNLTWSCRVNKTQHASTKLFLNLATLLPFCVCLMSFFLLILSLRRHIRRMQLSATGCRDPSTEAHVRALKAVISFLLLFIAYYLSFLIATSSYFMPETELAVIFGESIALIYPSSHSFILILGNNKLRHASLKVIWKVMSILKGRKFQQHKQI
Protein: ABC transporter, putative (Q586E5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ABC transporter, putative
- Multidrug resistance protein A
- Multidrug resistance protein E
Sequence:
MVAYASAASSYHAGVLVTSVVLSFGLGLTVWWLASGYRGRMRLRSRVVLVRFVKQVVDDWEEFCLREVEHWLAVRSPEGNIGEDSLFSNHGAKERGEVQDALPFHGPMRSMAYAPGVDLSRWLQLWNVGRRLCAALPEDMVLLERLGYIIKYTAFRRLATMAEARYYAAAWRSAVHGSDTKNGKAQIRRPRIPPWLVGHRPFWVVPLPSPGVGQFLCLPLSYFPVEAVLTSGAEETWVKDLADVLPLIMGQLSFKFLVDGLRTRQARRVAHATIRRRYPPSWKRLWREIDRLFNTFAAPLAKSQLERGRMARQRFCREKLYEGVELVSGDGPDMEEGMDGIFSVQSSEKVEGVMGRDVLLRDANLTRKLTLLLRFRTLSHAVRIAINLWAPRYNVFAGWMLPYVLSSSGCLEGRGAVLMDFARSVLWASLSAAVGAAVRSFDDVFRWKILVMLRDEVLHEVNVKIAVADEAFLRRCSSEGVGRSGGNPLARSFEYAESTAARMLGYFDCEQKKYISLIIGVVTAMLRQEVDVAAFAAAASLLNCYEISRAIGRWCGLLLDKSVEHEIARMGEEPLPAEPRYGLQLLLEVLAEENDGTTGTNAPVEGDAPVQNGSRASHSRYFLSLIACGGTFHVDWPVGPLPTHKKAQTDEVAYLRRLQKLFDTVVSGERACTLSCTSFICSPNDGALSIARGLRENAACVREFVLKERVQHALERNTVQTVPANSSEKLHAVNGGAKAALDAEEAALLARPQAMNRIPSTLGFDDVFSRPPRFILRQLGLDTVFAQRAALSVRRAESFTITMDLSDPISRPFHNVFRQLLLHLTEFIETLLFYSLLSYRSNLTSIWGVWPTWFTTRWACDGGATIAAEWSAASLLDRVSAYRALMRGNERVELDHPFRLTQQVARYMPTFVHDASPHNYSAVFKARRGLWRNKIKHVEGIQFDDAGRISEGFHLRKGIDFRGVWFVYPELHHCATDGSLQPSLANVTVHFPATQITAILGRTGSGKSTLLSLLKRTYDPVAVVSLKEGHVWEESEGLITVLQRCLDTQLPQANEGNCENVVTIDDIPLTCFSTTFLRQAVGMLEQTPFTFKGLSFLQNISLFTPRVSRDECVAAATLCRCKEFIESRPLGYDDKSKELSTGEKQRLALARAILVGRHGLGVCLLDEPTSHLDGHTAAYVEEAIGNLTTIQQPEVTVLLVSHRLSTIRYATHVVILDGGQLEYQGPADERKLRSNSFLRSAAGGQDLQIVRSAARPEGRTQGNVKSAIYADGLLKVSSVDA
Protein: Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) (P15624)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm.
Interaction partners:
- Phenylalanine--tRNA ligase alpha subunit
- Phenylalanine--tRNA ligase, mitochondrial
- Elongation factor 1-beta
- Leucine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, mitochondrial
- Small ribosomal subunit protein uS19
- Isoleucine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, cytoplasmic
- Small ribosomal subunit protein uS3
- Tryptophan--tRNA ligase, cytoplasmic
Sequence:
MPTVSVNKQQLFDLLGKNYTSQEFDELCFEFGMEMDEDTTEEALKTGEEPELKLDISANRYDLLCIEGISQSLNEYLERKERPDYKLSKPTTKLIIDKSTEQIRPFATAAVLRNIKLNEKSYASFIALQDKLHANLCRNRSLVAMGTHDLDSIEGPFHYRALPPKDIKFVPLNQTQEFTGDKLIEFYKSPEQKNNIGRYVHIIEDSPVFPVIMDSKDRVCSLPPLINSEHSKISVNTRNILIDITATDKTKAEIVLNILTTMFSRYCDEPFTVEPVEIVSEHNGQSRLAPNFNDRIMDVSIKYINSCLGLDQSADEIAHCLKKMSLHAVQSKEDKDILHVDIPVTRPDILHACDIMEDAAVGYGFNNLPKGEKLSNANFIAKPLPINKVSDIFRVASSQATWVEVLPLTLCSHDENFKFLRQSDNGDLAVKLANPKTLEYQVVRTTLLPGILKTVKENRKHSLPIKVFETGDVVFKDDKLERKAYNERHWAAIYVGKNSGFEIIQGLLGKIMQTFRTEWIADYGAAASGRGYWIEEDDSVKTYFPGRGAKVMFRSKEGAEPKQIGHLGVLHPEVMMNFDVPFAASFVEVNAEVFL
Protein: Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1) (Q9UHD0)
Organism: Homo sapiens (Human)
Function: Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-20 receptor subunit beta
- Interleukin-20 receptor subunit alpha
- Interleukin-24
- Interleukin-22 receptor subunit alpha-1
- Interleukin-10 receptor subunit beta
- Interleukin-20
- Interleukin-10 receptor subunit alpha
- Interleukin-26
- Interleukin-10
- Interleukin-22 receptor subunit alpha-2
Sequence:
MKLQCVSLWLLGTILILCSVDNHGLRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
Protein: PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (EC 2.7.11.1) (Q8CEE6)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. {ECO:0000250}.
Interaction partners:
Sequence:
MEDRGPPVFAEDWKCLSESPPVQEGPAAQATFEPSKPLSIAHKHLSRKNGLSRLCQSRMALSEDRWSSYCLSSLAAQNICTSKLHCAAAPEYADPTAGPLGSTSCCSLLRGLASGCSGSLLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRIGEKIPVSVWIKRLQQDRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKSKPSGRAVADSEAASEPGYQASVWVFCTISGLITLLPDGTIYGVNHSFALMLFGYGKTELLGKNITFLIPGFYHYMDLTYDSSVQLPDLVNCLDIGRKSGPGEMNSDAQHNWELASGAQGPRIDVVLARDHMPSQDETLKLVGGQVSSRTQTRLETGYKILPSSACQPSLGVDSNPEDGEQSLLTDQQSIPKRNLPAHGGQNQLDTSEISLPVLKEHLLSEIQKNISEESPLTHRKWLSKVQQNPTKGSLPIHEEQLLFAGQHIHVLGKEDPSAAESYRESLLEESKSKPVDAKLFASCEDSEPLVSVKDRGSSVDTCNLHQEAQLELMGVSSPNPWADATMPEPHTTGQIAGGSLTYCPQYRSEWASQQRGQDSAPSPSGMACVLLGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSCEGNLGISRVELVPEEHPPFTAPVSFCDLGGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVNSYSWNLKELFLKDQTDRTPSHCSCTTSELSEAPSLSVVGSDLDVGILHRQTSDILVDREMLLLTGTYFDLSEGQRFQEMGAGHDRAELSNISLVSSEHYETSDIESPGCDPPLPDPGPNDMCLSAEKPRPSAQITSTPVARGATSLQQEIQEGIYSGSCYHRDGLQLSIQFEVKRVELQGSATLFCCWLVKDLFHSHRDSATRTRLFLASLPSSTHSMPELSGSSFGEVLRAKPWFEESPTPAELEGLAACEGEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFIDHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLASYTWEEVCRTNQPESGLLSAASLEIGSRSPSEMAQREGLCGPPAPRETRGDQHCLHLKDPSLPVS
Protein: CRS1 / YhbY (CRM) domain-containing protein (Q9LS51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
- At3g18230
- protein SLOW GREEN 1
- Tetratricopeptide repeat
- At3g09490
- Ethylene-responsive transcription factor LEP
- Late embryogenesis abundant protein 31
- 1-Cys peroxiredoxin PER1
- Late embryogenesis abundant protein 6
Sequence:
MALAPLNFTEMPLRSSLPLTSSSRYCSSPSLHALLFYSLGVKPSRQQIVRPFSSLRTSERSNNRSNNNRRLDQRNHKPTPPWIDKWPPSSSGAGGDHAGKKGGENNGGDRIRSAEEEAEAKLRYLEKDKGQNAIERIVLRLRNLGLGSDDEDDVEDDEGGGINGGDVKPVTGEERLGDLLKREWVRPDMMLAEGEESEEEDEVLLPWEKNEEEQAAERVVGEGGVAVMQKRRARAPSLAELTVEDSELRRLRRDGMYLRVRINIPKAGLTQAVMEKIYDTWRKEELVRLKFHEVLARDMKTAHEIVERRTGGMVIWRAGSVMVVYRGLDYKGPPVISNQMAGPKETLFVPDVSSAGDEATNAKDNQSAPLVIKDPIIKNPIRKENMTEEEVEFNSLLDSLGPRFQEWWGTGVLPVDADLLPPTIPGYKTPFRLLPTGMRSNLTNAEMTNLRKIGKTLPCHFALGRNRNHQGLAAAILQIWEKSLIAKIAVKRGIQNTNNKLMADEVKTLTGGVLLLRNKYYIVIYRGKDFLPSSVAATLAERQELTKEIQDVEERVRNREIEAVQPVGDKVPAEAGTLAEFYEAQARWGKEITPDHREKMIEEASRVANARVVKRIQHKLNLAQSKFQRAEKLLSKIEASMIPNGPDYDQEVISEEERAMFRKVGLKMKAYLPIGIRGVFDGVIENMHLHWKHRELVKLISKQKNQAFVEETARLLEYESGGVLVAIEKVPKGFALIYYRGKNYRRPISLRPRNLLTKAKALKRSIAMQRHEALSQHISELERTIEQMQSQLTSKNPSYSESEWENDEDDDDDEEEEKDDVEDNESDWDETDGESAISSIEEADMSSR
Protein: Ribosomal protein L23a (O97118)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EKSAKPGDKKPEQKKTAAAPAAGKKEAAPSAAKPAAAAPKKAAAPAAKKAAPAAKKPATAGAAAKKPAAVKTTAAAKAKSKDAKKKVLAGKKPQSVLAKLSAKARAAAKAKKGVKPVTKPAKGTAKAKAVALLNAKKVQKKIIKAFGTRARKIRTNVHFRRPTTLKLPRSPKYPRKSVPTRNRMDAYNIIKYPLTTEAAMKKIEDNNTLVFLTHLRANKNHVRAAVRKLYDIKVAKVNVLIRPDGQKKAYVRLARDYDALDIANKIGII
Protein: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Q6R6M7)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Interaction partners:
Sequence:
MAFQKIKVASPIVEMDGDEMTRVIWKSIKDKLIFPFLELDIKYFDLGLPHRDQTDDKVTVESAEATLKYNVAIKCATITPDEARVEEFGLKSMWRSPNGTIRNILNGTVFREPIICKNVPRLIPGWTKPICIGRHAFGDQYRATDAVIKGPGKLKMVFVPEGKGETTDLEVYNFTGEGGVALAMYNTDESIRSFAEASMATALEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNGIASIFAWTRGLAHRAKLDDNAKLLELTEKLEAACIGAVESGKMTKDLALILHGSQLKREHYLNTEEFIDAVAAELKSKISA
Protein: Uncharacterized RNA-binding protein P16F5.06 (Q9HFE6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GTP-binding protein gtr1
- DNA-directed RNA polymerases I and III subunit RPAC2
- Large ribosomal subunit protein uL2m
Sequence:
MELEKRIYVGGLSSSIESSDLESRFSRFGSVSNLEIINKSTPVGTIQRFAYLNFRTDEDKWQKCKSYLSNATFKGSKLRIEEARPYYLVKLQQEKKIADLQSTNNDEKNEDHSSKVDLEDPVFHGEIIVPGKHSKNMQVVTDSDVRKDPPRKGWKKGPYGRAIVVLRMYNKNTKKTRFFYPLGKNCLQKLWGRVETNMDNTTAFYDSDHDEYVSYGGKRASRDKIRMQAKLGIKASTQKDDNDFELLNNTTGEIEVTKELNEEQLDALRKKDKDTAASVLAELFGSENTEEIDTVSKTSGVLELDNDSTNNFQKEGLDEQDNLQKEESVHIDVPAEFEAFDERTAVVNVDNLKEMFSSNAQDTSKFSLFGNENGVGEESEMESEIDDRNYETMEEEADGETPLAIVKASSGTKGWPKMFTLPNPSSLFQPGNEDYTSREALESWWSENRLFLTRDYKRKRKDAVKRQRRAHEKRIRLV
Protein: 3-ketoacyl-CoA thiolase 2, peroxisomal (EC 2.3.1.16) (Acetyl-CoA acyltransferase 2) (Beta-ketothiolase 2) (Peroxisomal 3-oxoacyl-CoA thiolase 2) (Peroxisome defective protein 1) (Q56WD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in long chain fatty-acid beta-oxidation prior to gluconeogenesis during germination and subsequent seedling growth. Confers sensitivity to 2,4-dichlorophenoxybutiric acid (2,4-DB). Required for local and systemic induction of jasmonic acid (JA) biosynthesis after wounding. Seems to be involved in JA biosynthesis during senescence.
Subcellular location: Peroxisome {ECO:0000269|PubMed:17120136, ECO:0000269|PubMed:9490742}. Glyoxysome {ECO:0000269|PubMed:9490742}. Note=Peroxisomal targeting signal type 2 (PTS2-type) import is temperature and ATP-dependent, induced by zinc ions and PTS1-type import, but repressed by mature forms of PED1 (PubMed:9490742). Does not seem to be targeted to mitochondria (PubMed:17120136). {ECO:0000269|PubMed:17120136, ECO:0000269|PubMed:9490742}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2
- Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1
- Putative peroxisomal acyl-coenzyme A oxidase 1.2
- Peroxisomal acyl-coenzyme A oxidase 1
- Peroxisome biogenesis protein 7
- Acyl-coenzyme A oxidase 4, peroxisomal
- Acyl-coenzyme A oxidase 3, peroxisomal
- Acyl-coenzyme A oxidase 2, peroxisomal
- Putative acyl-coenzyme A oxidase At3g06690
Sequence:
MEKAIERQRVLLEHLRPSSSSSHNYEASLSASACLAGDSAAYQRTSLYGDDVVIVAAHRTPLCKSKRGNFKDTYPDDLLAPVLRALIEKTNLNPSEVGDIVVGTVLAPGSQRASECRMAAFYAGFPETVAVRTVNRQCSSGLQAVADVAAAIKAGFYDIGIGAGLESMTTNPMAWEGSVNPAVKKFAQAQNCLLPMGVTSENVAQRFGVSRQEQDQAAVDSHRKAAAATAAGKFKDEIIPVKTKLVDPKTGDEKPITVSVDDGIRPTTTLASLGKLKPVFKKDGTTTAGNSSQVSDGAGAVLLMKRSVAMQKGLPVLGVFRTFAAVGVDPAIMGIGPAVAIPAAVKAAGLELDDIDLFEINEAFASQFVYCRNKLGLDPEKINVNGGAMAIGHPLGATGARCVATLLHEMKRRGKDCRFGVVSMCIGTGMGAAAVFERGDGVDELRNARKVEAQGLLSKDAR
Protein: Toxin Tma2 (C0HLM0)
Organism: Tityus macrochirus (Scorpion)
Function: Inhibits voltage-gated sodium channels (Nav). This toxin shows insect lethality against crickets.
Subcellular location: Secreted {ECO:0000269|PubMed:31402191}.
Interaction partners:
Sequence:
KKDDYPVDTAERNCKFECNIVDDKGYCDNLCKGRKAEKGYCYSLKASCYCYGLPDDSPTKTSKRCNPNV
Protein: PARP-type zinc finger-containing protein C2A9.07c (Q9Y7K9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00264, ECO:0000269|PubMed:16823372}. Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MAESGAGYRVELAKTGRAECKGTVCGRSKIGKGDLRFGTFVDVGKFQSWKWRHWGCVTERVLRNVNKKFEGDIKNCLDGFNELNDPIVQEKILRAFEQGHVDEEDEERCRKMASDASEEKDRKIEEGELTSEEEKEPIQDLRKSHKRKSVEKSSVPNKKHKAERKRSPSPKIEILEDDEEIEDVASDKDEEEKPWSGDEEDDDELVVKDSEDETEGVSTIASQRPRRSARRKVDYAESGNEYSDSD