wanglab/gogpt-training-data huggingface dataset:
Protein: Transport permease protein (Q6QWB5)
Organism: Azospirillum brasilense
Subcellular location: Cell inner membrane {ECO:0000256|RuleBase:RU361157}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361157}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTMAASAPQVPTGLAGLFTMPWHHRALLRRLVRREIEARYRGSLLGVVWALLTPVLMLAVFTFVFSVVFQARWGSSTGGKGEFALILFAGLIVFNMFSEALNRSPSLVLENPSYVKKVVFPLEVLPWVMVLSSLFQVVISLAILLVFHLAVSGLPPLSVLFLPLVWLPLLFLCLGTGFLFGALGVYLRDLRSIMPVASQLLMFLSPLFYPASALPESFRRLLHLNPLTGIIENTRTVLFAGTPPDWTVLGVQIVAGLLFATFSFRLFRHLRTGFADIV
Protein: Tyrosyl-DNA phosphodiesterase 1 (G3V2U6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVI
Protein: Small ribosomal subunit protein RACK1 (D6RAC2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR
Protein: Uncharacterized protein EXOC3-AS1 (EXOC3 antisense RNA 1) (EXOC3 antisense gene protein 1) (Q8N2X6)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MPAVFMLASSSALQCGRGVPRFPRTEVGAGHSVNEETKAEKVGNQTSVIPATSRQAALGTSWTQRRTQPLQERSHWHPRGNNASGMGGHRMFPGPLRGPAAQVLENECGSLGRAAEGRS
Protein: Large ribosomal subunit protein eL36x (60S ribosomal protein L36-3) (Q9LZ57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL39z/eL39x
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL22z
Sequence:
MVATGLFVGLNKGHVVTKREQPPRPNNRKGKTSKRTIFIRNLIKEVAGQAPYEKRITELLKVGKDKRALKVAKRKLGTHKRAKRKREEMSSVLRKMRSGGAGASEKKK
Protein: Uncharacterized protein (Q385U5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPDSPTSQRCAGSNNRKPKRVATRKADGGDQPLAVNGPSSPECIRTRTQKLEKELRELVLRNRSRHERLQNMRNRATLSSPPPSGPQSFERAARPSDESKPRSETEGRNKLPNLYKCFDEARTKSLLEYEKNKGSKESCMYSSYIPRDADLTPRGKQRDAMKDPDSFSLRFCSKLHPRDDSR
Protein: Acetylxylan esterase / glucomannan deacetylase (EC 3.1.1.-) (EC 3.1.1.72) (CjCE2A) (B3PIB0)
Organism: Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Function: Involved in the degradation of plant cell wall polysaccharides. Catalyzes the deacetylation of acetylated birchwood xylan and glucomannan, with equal efficiency, and of the synthetic substrate 4-nitrophenyl acetate (4-NPAc). Does not bind cellulose, cellohexaose and beta-glucan.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Cellulase, putative, cel5C
- Mucin-desulfating sulfatase
- Endo-1, 4-beta mannanase, man26B
- Cellulase, putative, cel5F
- Cellulase, putative, cel5D
- Endoglucanase
- 4-O-beta-D-mannosyl-D-glucose phosphorylase
- Putative 1,4-beta mannosidase man5D
- Endo-1, 4-beta mannanase, putative, man26C
- Mannan endo-1,4-beta-mannosidase
Sequence:
MKLLFPILLLTGSYFLSACNNTQSLMSSTHTIAASDPHIQVMGRTHINDDASLTFGYPGVSLSTIVAGSRLTAEMQSSNGNSWIDVIIDNHPPTSIKLDAQQQTVELFHFPNSGEHRVEIIHRSENWHGQVTLKQLTLTGTQFLPAPVLPQRKILVLGDSVTCGEAIDRVAGEDKNTRWWNARESYGMLTAKALDAQVQLVCWGGRGLIRSWNGKTDDANLPDFYQFTLGDTGQAPQWDHHRYQPDLIISAIGTNDFSPGIPDRATYINTYTRFVRTLLDNHPQATIVLTEGAILNGDKKAALVSYIGETRQQLHSNRVFYASSSHHPGDNSDAHPTKDQHAAMARELTPQLRQIMDW
Protein: Nuclear transport factor 2 (NTF2) family protein with RNA binding (RRM-RBD-RNP motifs) domain-containing protein (F4J8X6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 24
- NTF2-like protein
- Protein RETICULATA-RELATED 2
- Outer envelope protein 64, chloroplastic
- Dehydrodolichyl diphosphate synthase 6
- Myosin-9
Sequence:
MNFSVLLYINSKATFFSSSSIFLFSRRSLFFSRFSCKTLTSAIAKEAFLRSSLRNFPVNRQLRLFQFLDRFFITSICAYLLRESSSHLAFELDTDTHTAMAMLGAQQVPAAACTPDMVGNAFVPQYYHILHQSPEHVHRFYQEISKLGRPEENGLMSITSTLQAIDKKIMALGYGVISAEIATVDTQESHGGGYIVLVTGYLTGKDSVRRTFSQTFFLAPQETGYFVLNDMFRFIDEGTVVHGNQIPVNNVQAPVNTYQDTAAAKEIPDDFVQEKYVQENHAVKQTEVLSKSINEPEKVFTPSEDEQVSAAEEALVTETVNEAPIEVQKVGESDSRTGEIPKRSYASIVKVMKENAAPMSASRTPTKVEPKKQEDQAIHIPLPTPLSEKSDSGANVAVNENNQENERALGPSIYLKGLPLDATPALLENEFQKFGLIRTNGIQVRSQKGFCFGFVEFESASSMQSAIEASPVMLNGHKVVVEEKRSTARGNYRGRSTFGVNTGYRNEGGRGRGSFGGGRGGYGRTDFNGYGNNRGNNRGGYANRANGDGGGFPRANGNNGRVRRGGGNDANRATKPVDDAPRVSVAA
Protein: Secreted protein (Q38BQ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQHFVGGTVIHVLFFNFLRKCCACTVKVRKRIQCRICRKLIAVVWRRRKEKKMMIMMMGDTLTHIFIYLYIYIQAHGGGEKTKERKMVVWIRKVAQHIELSVNVFAT
Protein: AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1) (Q03989)
Organism: Homo sapiens (Human)
Function: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:8649988}.
Interaction partners:
Sequence:
MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPRDFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPKPKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGLVSCLLGPALGPVPPEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNTKL
Protein: G-protein coupled receptors family 1 profile domain-containing protein (O44986)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Tyramine beta-hydroxylase
- Serotonin-gated chloride channel mod-1
- Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
Sequence:
MEWMRNTLNGQFIAENSDFLSENTTTTTLGFTPITEESPNCSFYEWSRNPSHAQFFRIFSIISVLTVLVVVVVLGNALVIAAVLLRRRLRSATGLLILSLALADLLVGTVILPFSIANEVLDQYWIFGETWCTIWLTLDIWMCTASIYNLVAISIDRYIAIIKPLNYPMLVTKFRARCTVAIVWIGSFLICSPSFFLASSIKDKETPCRCTPANAGRVYVVFSASSSFYIPMIIVVFVYFRIYVAARAATKSIYSGMMSVTAAANKKQNPKSYLLNHPDVINKDSLPMLRVHRGSSVVAQITPNKPYNTCRQNGNSIDATANGTSQITAAATKARKFANDSAKTLVNRGAVGATQQAPIGARFKRHGRDSESSVDSMNGTNSYSATPHKSGNEELGSLIENSRSSSTDSNEKTEQLTNQTDDNFSMSNNNNNGDEKEAFDESLLSESKKKSKSLASKFNHLMRRGQKKRTAGAYEKRLSLEIKAAKTVAIVTGCFIFCWLGFALVYGLEIKLNDVVWSIVFWLGYLNSALNPVIYTVFNREFRICFKRLLTCHHLNHPTQKYTNNNSYNSTAIRSTNAVNRVPQTSLGNYTQTQNSEKSSAAVTFNTPTN
Protein: Protein masquerade (Q9VZH2)
Organism: Drosophila melanogaster (Fruit fly)
Function: In embryogenesis, has a role in somatic muscle attachment and in the development of axonal pathways probably by stabilizing cell-matrix adhesion and/or by acting as a competitive antagonist of serine proteases.
Subcellular location: Secreted {ECO:0000269|PubMed:7851790}. Cell projection, axon {ECO:0000269|PubMed:7851790, ECO:0000269|PubMed:8817456}. Note=Localizes to vesicle-like structures in epidermal cells. {ECO:0000305|PubMed:7851790, ECO:0000305|PubMed:8817456}.
Interaction partners:
Sequence:
MPRHSSTMSRLVLPLIFSILLVSKPSPSQAQDESLAGSFLSGLLDTITSTADSKDCPGVCVHTLATLICYEVLDDVACPSPSMKCCIENAPAGKNATAVRATTTPKTTTTASTTTTQRTTTTVATTSTTKRTTTTSTTPKPKPKPQTKRPATSSTTKATVATTKKPSTTKKVATAKPKDKEEATKADDANKDCTGVCVADRIAEYCEAYLTSDGLCKEGTKCCVSLDEYSNGKLPKDIYIPAKHMSNLKPNQTLSEKSAPAKSSSTSTTSTTTTTSTTTTPEPARINNSSPKPTKHKKHPTTTTTEAAEEEEEQETEEDGEEEEPPLSNKLKSGQGQGQVLKECEGECMNGIFAIFCDDIDSDAFCPGEESCCVTGGASEATPSSKAPPTKPAIKHAPKPAAKPARPASPPPAPPSSTSGGGGGGDFLSQIISFAESTLNSPSPPPPPPQAPIQVPRCPGFCLLNIMAAFCERPSVLVSTPTTCAKGSVCCDNSRAGAPKPKLPPPTPSPTASPTAPPYVLPNTPSPDPREECPGSCIVSLLSFTCFKNAEMTDLFRCKRSGQICCAPKSKILEKQQFQTRNDTAYYPAPPPPPIGPPQAYPPQTPPYSYMNNPPPQGPPPQMAPHHPNPYQPPPPAPNYADYYPVSGPGLPPQPQPPMTTPPTTTTTTTTPRPHVYSKYVCGVKGTLRTGRSQALSFVSYARAKYGVQRTARQMTSAAGYSPNFNKSNERLVLGSAIVPIQIHNDKLGDLVESSSLQSNQLRSYHNHQAQADQPDLVYPEYYQQRSLYGLQSNFSGRRRARVVGGEDGENGEWCWQVALINSLNQYLCGAALIGTQWVLTAAHCVTNIVRSGDAIYVRVGDYDLTRKYGSPGAQTLRVATTYIHHNHNSQTLDNDIALLKLHGQAELRDGVCLVCLPARGVSHAAGKRCTVTGYGYMGEAGPIPLRVREAEIPIVSDTECIRKVNAVTEKIFILPASSFCAGGEEGHDACQGDGGGPLVCQDDGFYELAGLVSWGFGCGRQDVPGVYVKTSSFIGWINQIISVNNL
Protein: 4-nitrophenylphosphatase (PNPPase) (EC 3.1.3.41) (Q59WC5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MSIKITSKDQVNQLLDKYDYFLFDCDGVLWLGDHLLPSIPEAISLLRSKNKQVIFVTNNSTKSRNDYLKKFEKLGIPDISKQEIFGSSYASAIFIDKILKLPKDKKVWVLGEKGIEQELHELGYTTVGGSDPDLISSGVDFDSNDPRLNKLDNDVGCVLCGLVFNLNYLKLSLTLQYLLKDKKTIPFIATNIDSTFPANGKLLIGAGSIIETVSFASGRQPEAICGKPNQSMMNSIKADFPDLGKTPKRGLMIGDRLNTDMKFGRDGGLDTLLVLTGIETEENVKSLNENETPTYYINKLGDFHELNN
Protein: Chemokine interleukin-8-like domain-containing protein (A0A060WT98)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- CXC chemokine d variant 1
- Chemokine interleukin-8-like domain-containing protein
- Chemokine interleukin-8-like domain-containing protein
- Stromal cell-derived factor 1
- Chemokine interleukin-8-like domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- C-X-C chemokine receptor type 2
- G-protein coupled receptors family 1 profile domain-containing protein
- Chemokine
Sequence:
MSIRMSASLVVVLLALLTITEGMSLRGMGADLRCRCIETESRRIGKLIKKVEMFPPSSHCRDTEIIATLSKSGQEICLDVSAPWVKKVIEKMLAK
Protein: Mediator of RNA polymerase II transcription subunit 25 (M0QZQ2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369088}.
Interaction partners:
Sequence:
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPAAKRKREGEGRVFREKWERAYFFVEVKSMPMCLICKQIVSVLKEYNLKRHYESKHSKSYDQYTEQTRDAILNELKKGLKCQ
Protein: Brevinin-2Ec (P84842)
Organism: Pelophylax saharicus (Sahara frog) (Rana saharica)
Function: Antimicrobial peptide (By similarity). Stimulates insulin release by BRIN-BD11 cells in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:16394170}.
Interaction partners:
Sequence:
GILLDKLKNFAKTAGKGVLQSLLNTASCKLSGQC
Protein: Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B) (Q8VBV8)
Organism: Mus musculus (Mouse)
Function: Stimulates two retinal guanylyl cyclase (GCs) GUCY2E and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2E and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P51177}; Lipid-anchor {ECO:0000250|UniProtKB:P51177}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15961391, ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000269|PubMed:15961391}.
Interaction partners:
- Retinal guanylyl cyclase 1
- Guanylate cyclase D
- Retinal guanylyl cyclase 2
- Guanylyl cyclase-activating protein 1
- Cyclic nucleotide-gated channel alpha-1
- Cyclic nucleotide-gated channel beta-1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Sequence:
MGQQLSWEEAEAAGEMDVAELQEWYKKFVVECPSGTLFMHEFKRFFKVTGNEEASQYVESMFRAFDKNGDNTIDFLEYVAALNLVLRGSLEHKLKWTFKIYDKDRNGCIDRLELLDIVEAIYKLKKACRAELDLEHQGQLLTPEEVVDRIFLLVDENGDGQLSLTEFIEGARRDKWVMKMLQMDINPGCWITQQRRRSAMF
Protein: Phosphatidylglycerol phospholipase (Q59S57)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Cardiolipin synthase
- Lysophospholipid acyltransferase
- Phosphatidylglycerophosphatase
Sequence:
MSTSSIIPKVAYQSLNRMTSTISPVIVGHRGFKSKYPENTFLGFDKCFEAGGTVIETDLWLTKDNEIVISHDQYTKRVFVDSDGNPTNYNITETPYDPILKHLKTIEGGYPLFTFKELLQWFKKYIDTTQSNDHKLQLDIKRFNPTKITKFIVQDLLTVHDDISWWYHRIQFGIWDLNFLKYLNQSDYFQDKFGKVNKFGYDQFDIFNISVNWRDSIHYINYNFYLDESSPVDRVKIKLTGVSLIYISTWSVGFLTKFVPLLRIQNLKLYSWTVNNKLQYSYLNKVGKLANLVEYGVISDYPDVMAKYKQEDESLTETESGEMSPLIKSESKDYYNEDGDLSIDLTLQQKFYHWIFVQFNSLVGKRVTIDEQHFATKVDENQVRSININPFFQWMFQKLQKYGVF
Protein: Small ribosomal subunit protein mS22 (28S ribosomal protein S22, mitochondrial) (MRP-S22) (S22mt) (P82650)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379}.
Interaction partners:
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein mS39
- Small ribosomal subunit protein mS34
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein mS25
Sequence:
MAPLGTTVLLWSLLRSSPGVERVCFRARIQPWHGGLLQPLPCSFEMGLPRRRFSSEAAESGSPETKKPTFMDEEVQSILTKMTGLNLQKTFKPAIQELKPPTYKLMTQAQLEEATRQAVEAAKVRLKMPPVLEERVPINDVLAEDKILEGTETTKYVFTDISYSIPHRERFIVVREPSGTLRKASWEERDRMIQVYFPKEGRKILTPIIFKEENLRTMYSQDRHVDVLNLCFAQFEPDSTEYIKVHHKTYEDIDKRGKYDLLRSTRYFGGMVWYFVNNKKIDGLLIDQIQRDLIDDATNLVQLYHVLHPDGQSAQGAKDQAAEGINLIKVFAKTEAQKGAYIELTLQTYQEALSRHSAAS
Protein: Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8) (Q68CQ1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MALSPGANLVFHEDPKMTPSPPSCGAPGLGSGTIPQPHPDMAQVPMLNLLPSPGLALVPDLNDSLSPVSGEASGLVSENTPRPDDSRAIAPASLQITSSCSGEALDLDSKDVSRPDSQGRLCPASNPILSPSSTEAPRLSSGNHPQSNSEDAFKCLSSKIFKLGQRNSNPSRHELNPFIRHHSREGLVLGHCISRPSSKALLIPTSNSSLDLDSNPLLNMGSRNTSKLNLNVAPDSHGTLIPDTNETITLASHNISESVSKGAFSTTWSTSSKETMNVASSGHSRSDLSVTITQASYVTLIPGSSYGISLHSSTHEPNSTISPPSCMTLILGSNETLSLDSSLLFSDTSTLTLSSQQDDAKDNSIHTVPLEENLESWSEMASIKVGQFPLGFPISNPAGKDAVTLQGIPEGAFDEVTSCLVKVPEKTEGGNNMALVENVTTLQKSQDLLEAEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEILTQLSHTQPTLGMRERSELVNVCVHSVFSLPSVQAMQEKDEAKAETIQALYHQTLEALQTLLKALFIEDPTPAGLKSILEALGPWMNSGKAHERARAVNTNVSVLNHMLLTLPFFMPLGFPALGLLLGRLILHIGDPDEEIGCEALDGIIILYTILELQKRARDKEETNKKELYESNKHFLGPYNPVSPCQNILRVIEEFGDFLGPQQIKDLLLAALEGLKGSSEAPGKDSREMMQLASEVMLSSVLEWYRHRALEVIPEIMQGIYMQLSHIQEPRARQVALLPVSLLASSFMTEVVVALLMCPLPLNSNGAEMWRQLILCKPSCDVRDLLDLLLGSLKEKPVTKEGRASIVPLAAASGLCELLSVNSCMGRVRRIYPQLLLALLIQVHYHIGLNLPGCVAPPKDTKKGAQPSPFVPVRWVVKVVKTLLLRMGCSYETTFLEDQGGWELMEQVESHHRGVALLARAMVQYSCQELCRILYLLIPLLERGDEKHRITATAFFVELLQMEQVRRIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILARRSEKTAKVKALLPSMVKGLKNMDGMLVVEAVHNLKAVFKGRDQKLMDSAVYVEMLQILLPHFSDAREVVRSSCINLYGKVVQKLRAPRTQAMEEQLVSTLVPLLLTMQEGNSKVSQKCVKTLLRCSYFMAWELPKRAYSRKPWDNQQQTVAKICKCLVNTHRDSAFIFLSQSLEYAKNSRASLRKCSVMFIGSLVPCMESIMTEDRLNEVKAALDNLRHDPEASVCIYAAQVQDHILASCWQNSWLPHGNSWVCYSATTHRWSPSCENLPTSHQRRSWIMQALGSWKMSLKK
Protein: Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV) (Q675A5)
Organism: Rattus norvegicus (Rat)
Function: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments. Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).
Subcellular location: Lysosome {ECO:0000250|UniProtKB:Q6XPZ3}. Secreted {ECO:0000250|UniProtKB:Q8NCC3}. Membrane {ECO:0000250|UniProtKB:Q8NCC3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NCC3}.
Interaction partners:
- lysophospholipase
- Acyl-protein thioesterase 1
- Patatin-like phospholipase domain-containing protein 7
- Phospholipase B1, membrane-associated
- Phosphatidylcholine-sterol acyltransferase
- Glycerophosphocholine phosphodiesterase GPCPD1
- Phospholipase A2, group III
- Phospholipase A and acyltransferase 3
- Cytosolic phospholipase A2
- Phospholipase A2
Sequence:
MDRHLCICREIQLRSGLLFPFLLLMMLADLALPAQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKRTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRTTQFPDGVDVRVPGFGETFSLEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALQEMIEEMYQMYGGPVVLVAHSMGNMYMLYFLQRQPQAWKDKYIQAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSHEKVFVYTPTANYTLRDYHRFFQDIGFEDGWFMRQDTQGLVEALVPPGVELHCLYGTGVPTPNSFYYENFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHKVSLQELPGSEHIEMLANATTLAYLKRVLLEEP
Protein: Proline-rich spliceosome-associated (PSP) family protein (A0A1P8B4Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nuclear protein-like
- Uncharacterized protein At3g23325
- Splicing factor 3B subunit 4
- At2g32600/T26B15.16
- Small nuclear ribonucleoprotein Sm D2
- Uncharacterized protein At4g14342
- Splicing factor SF3a60 homolog
- RNA-binding
- Splicing factor 3B subunit 6-like protein
- PHD finger-like domain-containing protein 5A
Sequence:
MTADSTVALVHSVVSNGDVSNGNTSASSKKSREIDRRRRRRKQKKNNKASQADVDASDVSAASESKENTDPQPQVCEQIVIEYVPEQAEFEDGFNDEFKEIFEKFNFREPLASEEDGTKDESEEKEDVKKKVNSDSDSDDDEQDNQNKEKGISNKKKKLQRRMKIAELKQVSARPDVVEVWDATSADPKLLVFLKSYRNTVPVPRHWSQKRKYLQENICDNHGAWTCRCNRRGLLIFFFCLYMKSVVLRFWSKLFNESVWDIPFLKLYFVFVCMIVILLLDASVFVVLLYCFFFLFISWWHLSGVSFLQGKRGIEKQPFHLPDFIAATGIEKIRQAYIEKEDGKKLKQKQRERMQPKMGKMDIDYQVLHDAFFKYQTKPKLSALGDLYFEGKEFEVKLRETKPGFLSNDLKEALGMPEGAPPPWLINMQRYGPPPSYPHLKIPGLNAPIPIGASFGFHAGGWGKPPVDEYGRPLYGDVFGVQQQDQPNYEEEPIDKSKHWGDLEEEEEEEEEEEEEQEEEMDEEELEDGTESVDTLSSTPTGIETPDAIELRKDQRKEPDRALYQVLEEKGESVAPGTLLGTSHTYVIKTGTQEKTGAKRVDLLRGQKTDRVDVSLQPEELDAMENVLPAKYEEAREEEKLRNKPVDLSDMVVEHVQQNSRKRKMHDKEGKKKKDFKF
Protein: F-box/LRR-repeat protein 15 (Q9BMW6)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MADPIAVNFRRARFPNTPPAQLLTVIVSYRRGCAPLALLAVSPTARRAVEETGCAIGGLRVIHKNNDVKKCDDVRFVAPEELELAASNKQSLQSAVFGLWWYKRYPFTSLVVDHAGKENMPLIIRLKKALNIKKMVILKSAVTNEMMHIVSMARDLESLTVRNCFSESEASLCSVTSILNSRATNRRDARTFYLSGVTSLGVLRCLRSLTLFATPLSNQIMSYFCECTNLERVVVDSCCGLVSLECFAALQRLTHLSVLNCTITDEGLPPISKCFSLQYVMLDNCMKLRSLNCLGSLRNLRTLIVSRNRIPEEGVQGLRKLRDLEVLRFSVFNRPTAVEFISSLGSLVELDLRDNWVGDAGCASFVHCRQLQQLKLSCCRRVSDVRWLAALTCLRTLDLSHTNVRSRWLESLRACRYLVELNVAYCRDVVEVSFLSELRLLKHLDLSGTDIGEQNLDPIGQCEGLTFLLLKDCSSVKDLHFLETLRELVKLDTERTGIMDANVCQVVACKKLEFLSFRYCHLLTDVKCLEGLRNLKTLDLAGTNVTNEGISSLPKCVSLEYVDVSECCLITHLEFLRPLPNLQQVVADQMNLTDIGGLTGAPSLRRVTLNESKRLGTVGEVRLPYLQELSLRKSTISNAGIRSLLASCRSLQHLDMQHCHSVTELSALSQLPNLRELLLRNIRVTGEFMTHIASCVNLRKLQMTECADITDVNCLSALQSLEDIDLSRTSVTTEGIKGLSKCYALRKLNLSECRYVTNVNCLGKLPFLRELHLEKTNVTDKGIAGLSNCIQLETLALTKCSRITNVERLHSSLPHLEEFDVYGTSVDKFHRCLGGSQRTQHACSVL
Protein: Sodium-dependent high-affinity dicarboxylate transporter 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (ceNaDC3) (Q21339)
Organism: Caenorhabditis elegans
Function: High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Plays a role in the regulation of life span.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
Sequence:
MSLSLHLSGWPENSESRQRMLESSSSTNFVQHFVSREISNKERLLSLFRRLRNGLVLVLTPLFFGQMLNWEGPEWKCAYCVCIIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEPKWIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSFQHHPTNGERGRLGCKKMATGLVLSICFAANIGGTGTATGTPSNLVMLGQLSALFPKVDGSLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTEMLKTRYNELPRMTYAEKSVFVCFCILLSLWVFRNPGVVPGFGVFFKKGAYTDATSAMIVAFLLFVLPSERPDLATYIKKEDLKKRGCLMDWKTMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATLAQRAGHHPFTLMLPTTLASSFAFIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLYMNSIAYLTLPLLEFPTWAIIANSTMQQ