wanglab/gogpt-training-data huggingface dataset:
Protein: WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (Q80W47)
Organism: Mus musculus (Mouse)
Function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (By similarity). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:23051912, ECO:0000269|PubMed:23291478, ECO:0000269|PubMed:24954904}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y4P8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Y4P8}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000250|UniProtKB:Q9Y4P8}.
Interaction partners:
- Autophagy-related protein 16-1
- Ubiquitin-like protein ATG12
- Autophagy-related protein 2 homolog A
- Autophagy protein 5
- Autophagy-related protein 2 homolog B
- Protein Atg16l2
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Tectonin beta-propeller repeat-containing protein 1
- Autophagy-related protein 9A
- WD repeat domain phosphoinositide-interacting protein 1
Sequence:
MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLEAVREKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLATQTYGTAAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Protein: Midkine (MK) (Q9DDG2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU369117}.
Interaction partners:
- ALK tyrosine kinase receptor
- Protein tyrosine phosphatase receptor type Z1b.
- Pleiotrophin
Sequence:
MRSLFSIALVLVVVSMITVEASMKKKEKGKEPKADAECSEWQYGKCVPNSGDCGNGIREATCNEQTKKTKCKVPCNWKKDFGADCKYKFGRWAECDTTTGTRSRSGTLKKALFNAECQTTIKVSKPCTPKTPKPKGGEKKKGKGKEN
Protein: Ras-like protein family member 12 (EC 3.6.5.2) (Ras-like protein Ris) (Q9NYN1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSVFGKPRAGSGPQSAPLEVNLAILGRRGAGKSALTVKFLTKRFISEYDPNLEDTYSSEETVDHQPVHLRVMDTADLDTPRNCERYLNWAHAFLVVYSVDSRQSFDSSSSYLELLALHAKETQRSIPALLLGNKLDMAQYRQVTKAEGVALAGRFGCLFFEVSACLDFEHVQHVFHEAVREARRELEKSPLTRPLFISEERALPHQAPLTARHGLASCTFNTLSTINLKEMPTVAQAKLVTVKSSRAQSKRKAPTLTLLKGFKIF
Protein: MHC-linked complement C4 (Q076D6)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MGLLLAAVGPVTGTVTAWAEGDRGAGPCTLPVPFALTPHNNFNQLLQIEVTPVQAERCGALWGRGLLLEAHSSHLPPPSTRSLSVALGGPRGHLIVQTDKPLYAPRQTVRFRVFSMDPDLQPNPEPVLVTITNPLGARVREVQRVPLDTVLSDQLVLPDIALPGTWHIRAQLAASPNTNGSTAFEVRKYVLPGFEVRIRPERGFIVLSDPDPAPLRIHLHVQFPDGAPVWGRAQLRVGLRDARGQGGRFLRGLEQQSQVTEGHASLEVSPVGVAKAAGVALADLQGALLRLAVGVVESAGGELVERELSVPLVLSQWVLQLQKSARFFVPGAPYTLLGRVLQAGGGTAPGVPIRVTVGVTGAPAPPLIELQADNSGDIAVPINVPRGATRMELSVEAGQPGVPPARAQLLVTPMAAVSGRFLVLGGPRGSLRPGEELRLQLHHMGPPPTPQRFHILAMARGRVLVAHTVASQVTLTEVALPVTADMAPYLHVVAFFLSGGNVVAATWGGAVRGGCDEQVQVKVPPRGTTLRPQDPLKVTVTTGTPVTVAIGAIDTTVLNLEPRHRLNTAKVEAALGSSDLGCSPEGGPDAVGIFGAAGLVLGLQGGSPTVPAAPHCPPAPTRQRRSLELLKLLEEKAGPWRNNTVMWRCCRDGATALPIRATCQQRGQRVTTAGGCRDAFLQCCEVAQNLRRKGQRGGLARVMEAQLAEQLLDDDEDVPTRSFFPESWLWRRIHVAGTARLSVLLPDSITTWEIQAVAIVPGHGLCVAEPQRVTVTQDVRVALRLPPSIRPLEQMQLQPLIHSRLPRSINVTVTLSAVEGVCAALDGVPQMLELPPGRAVAAPLTLVALHPGDIPITITARGPWGLGDRVTRVLHVEPEGELHLEESTYILDADDKRSRSLKLPGDVPAEIVPDGDFSMSIRVSGRVPGWALQGALGIGDSLLRSPRGCGEQSLMSMAPTAAALRFLDESEGWGQLPPGHRQRGLRTLQQGFERVQSFRKSDGSYGAWLHRDSSTWLTALVLRVLALSRPYLPVAASGPAASLRWVLGQQRPDGAFLEHRAVVHREMQGGVADPGPEATVSLTAFVVVALHGARALLPPDSPELPLLDKSLSRASTFLRGRVEQLGTYGTAITSYALALVDTAPPGPHPAVERLRGMARSAHGGRATFWPSGGPAATVEATGYALLALLQSRDIAGAARAARWLRQQSNYGGGFHSTQDTLVALEALAQMWLHWGRGNTMGLNLGLSWPGGARGRAGGTQVMLKPGLEPLEQELQVPLGSPVTVQVEGHGEGTLTVLRQFRLLSPPNATCQALHLEVAITGPILYHADEDYEDYEDYEEAEPKEGEEPTEGAVPVEGAGPADDPAPLSPVSLWDARKRQRRSTHNPAHEVAFLVCFRRSPGVALTGMAVVEITLLSGFSPHRADLDKLRDVVDHWISHYELEGNQLVLYLDEVPPERQCLSFGATQDAAVGHMQPAMAAIYDYYEPGQRCTVFYNAPQRSSTIATLCSPKICECAQGGCPQAQRRTQEVTADDRHDFACYSPRVDYALVVRVLSQSEIGAFVAFETEIKEVLLEGQDTAVAPGERRRLLVRKSCPLRLQLHNIYLVMGGSGRTRDPEGRPQFLLGPHSWLEEVPSPGRCKATRLRGYCAQLQEFRTRLSQLGCQL
Protein: MYB67 (A0A384L704)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MREKWEMKRDEMGHRCCGKHKVKRGLWSPEEDEKLLRYITTHGHPSWSSVPKLAGLQRCGKSCRLRWINYLRPDLRRGSFNEEEEQIIIDVHRILGNKWAQIAKHLPGRTDNEVKNFWNSCIKKKLLSQGLDPSTHNLMPSHKRSSSSNNNNIPKPNKTTSIMKNPTDLDQSTTAFSITNINPPTSTKPNKLKSPNQTTIPSQTVIPINDNMSSTQTMIPINDPMSSLLDDENMIPHWSDVDGMAIHEAPMLPSDKAVVGVDDDDLNMDILFNTPSSSAFDPDFASIFSSAMSIDFNPMDDLGSWTF
Protein: 25-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.29) (Cytochrome P450 7B1) (Hippocampal transcript 1 protein) (HCT-1) (Oxysterol 7-alpha-hydroxylase) (Q63688)
Organism: Rattus norvegicus (Rat)
Function: Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Sterol 26-hydroxylase, mitochondrial
- Cholesterol 25-hydroxylase
- 3 beta-hydroxysteroid dehydrogenase type 7
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- Cholesterol side-chain cleavage enzyme, mitochondrial
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- Steroid 21-hydroxylase
- Sulfotransferase 2B1
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Steryl-sulfatase
Sequence:
ALEYQYVMKNPKQLSFEKFSRRLSAKAFSVKKLLTNDDLSNDIHRGYLLLQGKSLDGLLETMIQEVKEIFESRLLKLTDWNTARVFDFCSSLVFEITFTTIYGKILAANKKQIISELRDDFLKFDDHFPYLVSDIPIQLLRNAEFMQKKIIKCLTPEKVAQMQRRSEIVQERQEMLKKYYGHEEFEIGAHHLGLLWASLANTIPAMFWAMYYLLQHPEAMEVLRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESAILEVLRLCSYSSIIREVQEDMDFSSESRSYRLRKGDFVAVFPPMIHNDPEVFDAPKDFRFDRFVEDGKKKTTFFKGGKKLKSYIIPFGLGTSKCPGRYFAINEMKLLVIILLTYFDLEVIDTKPIGLNHSRMFLGIQHPDSDISFRYKAKSWRS
Protein: Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)] (P03274)
Organism: Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Function: During virus assembly, promotes hexon trimers nuclear import through nuclear pore complexes via an importin alpha/beta-dependent mechanism. By analogy to herpesviruses capsid assembly, might act as a chaperone to promote the formation of the icosahedral capsid.
Subcellular location: [Pre-protein VI]: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04048}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04048}. Note=Shuttles between host cytoplasm and nucleus. {ECO:0000255|HAMAP-Rule:MF_04048}.; SUBCELLULAR LOCATION: [Endosome lysis protein]: Virion {ECO:0000255|HAMAP-Rule:MF_04048}. Note=Associates with the base of each peripentonal hexon on the capsid interior. Present in around 360 copies per virion. {ECO:0000255|HAMAP-Rule:MF_04048}.
Interaction partners:
Sequence:
MEDINFASLAPRHGSRPFMGNWQDIGTSNMSGGAFSWGSLWSGIKNFGSTIKNYGSKAWNSSTGQMLRDKLKEQNFQQKVVDGLASGISGVVDLANQAVQNKINSKLDPRPPVEEPPPAVETVSPEGRGEKRPRPDREETLVTQIDEPPSYEEALKQGLPTTRPIAPMATGVLGQHTPVTLDLPPPADTQQKPVLPGPSAVVVTRPSRASLRRAASGPRSMRPVASGNWQSTLNSIVGLGVQSLKRRRCF
Protein: Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) (P42785)
Organism: Homo sapiens (Human)
Function: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Subcellular location: Lysosome.
Interaction partners:
- Angiotensin-converting enzyme 2
- Dipeptidyl peptidase 4
- Neprilysin
- Meprin A subunit alpha
- Meprin A subunit beta
- Xaa-Pro aminopeptidase 2
- Prolyl endopeptidase
- Kininogen-1
- Plasma kallikrein
- Angiotensinogen
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
Protein: Alpha-tectorin (O08523)
Organism: Mus musculus (Mouse)
Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Subcellular location: Cell membrane {ECO:0000305|PubMed:9079715}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:9079715}; Extracellular side {ECO:0000305|PubMed:9079715}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9079715}. Note=Found in the non-collagenous matrix of the tectorial membrane.
Interaction partners:
- Cell adhesion molecule CEACAM16
- Ubiquitin-like protein FUBI
- Otolin-1
- Otoancorin
- Stereocilin
Sequence:
MNYSSLLRIWVSFIFALVRHQAQPRELMYPFWQNDTRTPKVDDGSSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFIAPFWADVHNGIRGEIYYRETMDPAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDDLNCTIKCRCLDFNNEIYCQEASCSPYEVCEPKGRFFYCSPVETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVNGYKILIPKGSYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCGSGCVDNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGDVYCFNKTCRSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTLLKTCPERPEYLEIDINKKKPDAGPAWLRGVRILVADQEVKIGGVGALEVKLNGQDVELPFFHPSGRLEIHRNKNSTTVESKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCPLECPENSHFEECMTCTETCETLALGPICVDSCSEGCQCDEGYALQGSQCVPRSECGCNFEGHQLATNETFWVDQDCQIFCYCNGTDNSVHCETIPCRDDEYCMEESGLYYCQPRTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRPISDSFPKFIVTAKNEDRDPSLALWVKQVDVNVFGYSIVIHRAYKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVYDWKTFLSITVPRSMQNGTYGLCGRYNGNPDDDLEMPMGLPALSINEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTSCSVTCPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLNGKSCILPHNCGCYSDGKYYEPKQLFWNGDCTRRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNLTIISPVYFYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISISERLQNKVCGLCGNFNGDMTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLAPSCNELQFSQYAATCDNVHIQAMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELDNGGELCGCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSGIEGEDFISFQINNTKGNCGNIVQSNGTHIMYKNTIWIESANNTGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLYVGVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIGIEENGVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQNSRIATDYSKEHKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGSLQEDGRSCRASNSSVELQVWTLLLIMTQISLWHLIYKSGATS
Protein: ATP-dependent RNA helicase RhlE (EC 3.6.4.13) (P25888)
Organism: Escherichia coli (strain K12)
Function: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. May play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00968, ECO:0000269|PubMed:18083833}. Note=Ribosome-associated. Can either bind to the intact 70S ribosome or to individual ribosomal subunits.
Interaction partners:
- Ribonuclease R
- Polyribonucleotide nucleotidyltransferase
- Ribonuclease E
- Large ribosomal subunit protein uL3
Sequence:
MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLTKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASDQVTQHVHFVDKKRKRELLSHMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEIPRIAIPGYEPDPSIKAEPIQNGRQQRGGGGRGQGGGRGQQQPRRGEGGAKSASAKPAEKPSRRLGDAKPAGEQQRRRRPRKPAAAQ
Protein: Erythroid differentiation regulator (Q811B0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLGLVRPPVTAAAPSDVTHTRRSGRRGQDVSAMPTGRTDARTDGLTPQGRKPAPTAPPHPPQHTGHTRAPRPPRHTRHTRHTRQAGQAHASAGPAAPATQTRTSRRGQDVHPPRSRCMCHRPSPRWTDGRTRARRQRPPVTAAAHSDVTHESTHVEADAVVKMSLPSPQDGRTDSTRCACRRGRQDGAILTEEGARQQGLTAYRNAPPQ
Protein: Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) (Q15424)
Organism: Homo sapiens (Human)
Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Thereby acts as a negative regulator of cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:19674106, ECO:0000269|PubMed:22693546}.
Interaction partners:
- Tight junction protein 2
- Estrogen receptor
- RNA-binding motif protein, X chromosome
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoprotein U
- Serine/arginine-rich splicing factor 1
- KH domain-containing, RNA-binding, signal transduction-associated protein 1
- Matrin-3
- SRSF protein kinase 1
- Enhancer of rudimentary homolog
Sequence:
MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGGMMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQSRGSRPSDARFTRRY
Protein: Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Transmembrane protein 9) (Protein TMEM9) (Q9CR23)
Organism: Mus musculus (Mouse)
Function: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q9P0T7}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9P0T7}; Single-pass type I membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9P0T7}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKLLCLVAVVGCLLVPPAQANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARTMATAAASIGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
Protein: Regulator of chromosome condensation (RCC1) family protein (Q0WSJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVTATSIIAWGSGEDGQLGIGTNEEKEWACVVEALEPYSVRSVVSGSRNSLAICDDGTMFTWGWNQRGTLGHQPETKTENIPSRVKALANVKITQAAIGGWHCLAVDDQGRAYAWGGNEYGQCGEEPLKDEMGRPVRRDIVIPKRCAPKLTVRQVAAGGTHSVVLTREGHVWTWGQPWPPGDIKQISVPVRVQGLENVRLIAVGAFHNLALEEDGRLLAWGNNEYGQLGTGDTQPTSHPVPVQGLDDLTLVDIAAGGWHSTALTDKGEVYGWGRGEHGRLGLGDNDKSSKMVPQKVNLLAEEDIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPLELPIKIPPPEGSFNHTDEEEEGKWSAKSIACGGRHTLAIVEWKSDDI
Protein: Alpha-parvin (Actopaxin) (Q9HB97)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Subcellular location: Cell junction, focal adhesion {ECO:0000269|PubMed:11134073}. Cell membrane {ECO:0000269|PubMed:11134073}; Peripheral membrane protein {ECO:0000269|PubMed:11134073}; Cytoplasmic side {ECO:0000269|PubMed:11134073}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11134073}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Interaction partners:
- Paxillin
- Scaffold protein ILK
- LIM and senescent cell antigen-like-containing domain protein
- Parvin, beta
- Ras suppressor protein 1
- Actin, cytoplasmic 1
- LIM and senescent cell antigen-like-containing domain protein
- Gamma-parvin
- Actin, cytoplasmic 2
- Dual specificity testis-specific protein kinase 1
Sequence:
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTMLEENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINEALKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
Protein: RNA-binding protein (Q38DG9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEGTGGKVKGLSSLELKALSVPFALRFLLGVECDVVLCVTEVGNRRPFSIRFPSLSNAFKELLQLCALRYDLSCEHYDDHSLFTGILKFPILRYIDYIPGALHMEEVLGCLGVESIRSPKRLGESLHEFVASFIDYKDYQPDAALDPLNNGLYLTLDYGLSTATHSHLVEIQFHRGWDVDAALREFEEFSRLTANDIRFIDENNRGRGGVLVMPSTQDASDLFERYEDEDSDDEGELLPFVLRPVAPMVPVPSVEDSTLRKHREQYWKEIETFWKRFPIWSNTVVVSNLYDGATLEDALRLFDGLAIAKATMVECDTPARRRKLYVTFETSAVARTALSSDSMSTKGKTLRVQVSPPFLNEERRGRVIETISSPTSSPSLRSKCYPTGLTGSPNCTTAEPEGVHNERKETEGRRRDAHAVSGKSRDSAPALVNTESKHNAYTTPKLKPKTPDVMCQSPSPVSSTMNANAREFVPSSAFHASTPTTSAYVSPVPLVCVSEVLLSPPAYSLHGSSVRQDVGLGGGPPPPPPPYTAPPPYGVAAVQTVGMFPSHVLPPPHQSA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8INB6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQK
Protein: Protein fem-1 homolog A-A (FEM1a-A) (FEM1-alpha-A) (Prostaglandin E receptor 4-associated protein) (Q9Z2G1)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19406122}. Cytoplasm {ECO:0000250|UniProtKB:Q9BSK4}.
Interaction partners:
- Cullin-2
- Elongin-B
- E3 ubiquitin-protein ligase RBX1
- Kelch domain-containing protein 2
- DCN1-like protein 2
- Amyloid protein-binding protein 2
- Protein fem-1 homolog B
- Protein zer-1 homolog
- Kelch domain-containing protein 10
- Protein zyg-11 homolog B
Sequence:
MDLHTAVYNAAHDGKLPLLQKLLAGRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHEQLSGTELPGEGSSQVAGNHCSTPEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGYLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGVFPSLQVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH
Protein: exo-alpha-sialidase (EC 3.2.1.18) (A0JMM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Arylsulfatase A.
- UDP glycosyltransferase 8
- Beta-galactoside alpha-2,6-sialyltransferase 2
- Galactosylceramidase b.
- Alpha-galactosidase
- Galactocerebrosidase
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Sequence:
MGNKTPSKSKSGYPKEMNTTTVFKQEQPQTWCCCFKKQVSYRIPALVYVSDEQTFLAFAEKRKTLNDTNAEVLVMRRGTWVDAKTKEVEWICGHQVLSSASLPNHRSMNPCPVYERDSKTLFLFFVCVPTQVSEFDQIRTNKSQGRLCYVTSKDAGKTWSQTIDLTADVIGEQVNEWAPFAVGPGHGVQTKNGRLIIPAYAYRYTGKTDCTSCCCLSFCCFTPYALAFYSDDQGITWKAGQQMDVESCECQMAEIVGEKGDSTLYCNARTRLGYRTEALSNNAGEDFDTVLSSSKLIETGKGCQGSVLSFVEQSSPPQTWLLYSHPSHPKKRVDLGLYLNKSPLDSSGWSDEPLMILHHGPSAYSDLVEFEPGHFACLMECGKEHENEEIAFLLFKLPEKKL