wanglab/gogpt-training-data huggingface dataset:
Protein: Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) (P19022)
Organism: Homo sapiens (Human)
Function: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23863954}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15116}. Cell junction {ECO:0000269|PubMed:28169360}. Cell surface {ECO:0000250|UniProtKB:P15116}. Cell junction, desmosome {ECO:0000250|UniProtKB:P15116}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P15116}. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. {ECO:0000250|UniProtKB:P15116}.
Interaction partners:
- Catenin delta-1
- Catenin beta-1
- Cadherin-1
- Catenin alpha-1
- Glutamate receptor 2
- Junction plakoglobin
- Neural cell adhesion molecule 1
- Cadherin-11
- Gap junction alpha-1 protein
- Fibroblast growth factor receptor 1
Sequence:
MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD
Protein: Uncharacterized protein (O45750)
Organism: Caenorhabditis elegans
Interaction partners:
- Osmotic avoidance abnormal protein 8
- Delta and OSM-11-like
- Glycerol-3-phosphate dehydrogenase [NAD
- Protein lin-12
- SSD domain-containing protein
Sequence:
MRFRSLGALSVLLLFLQLPGPSSEYELSINHEEVTDSDRRVLLEIAKAVKRVKRNPFKRDEGRSSVDSDLRQKEDNGDDNGGDEESEGKPENFQGSANDYCDKFEQHFSYFCVGETDQTDKNAYVIKKFCPSYKTACKHKAVTTSVSLTSWPTDPFAKEITVASRPLPSTSGRTSHSRRRDSDEDSDSAEDEEVYYAELRKRYPCKPDCDKRIFAHCTEECKCDYIYPVVQRFCNPPPMPMFLNTCRLWYHGCPKYERYHYASQFVYSKAEKGKVLPGSPDQASVNPYGLPQPAPLRNRALALAPIRRQKRDAENEDLVVPPPVPSEIQEREASLTAPESRAILQNYRENLKSGEKKKRRSRRKKLRRRRRHRQRFSFDKDFEEITTTKRPPTPRELWRALKQLNSLTSGPGAVGLKSSPATLKGGGEAQGGLDGLLASVTQPQRERDEAARQWATVDARQLTEDIVHSVVTTEKDAEHKEAKKEAEPEPNFDKIKPRTFAMSSVAATTAIVDEQPEVPKKASSGRAKAHQGNIPILPSDATFAAQGSGDDTFRAFDGLSDSRGLVHTPRSRSPFTKPGLWEPNPADPHSRDPANKYWYHPESVGVDWLNGQLQWGGHWAVPAAGAGGTAGMSAVHFPTIGSFLNIPDDYD
Protein: Elongation factor Tu domain-containing protein (Q54WF2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS30
- Ribosome maturation protein SBDS
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL1
Sequence:
MPSISPNLLASLQDHTKNIRNICVLAHVDHGKTTLSDCLISSNGIISPEMAGKLRYLDFLEDEQEREITMKASAISLLFQQPSSSSSSNDKESFLINLIDSPGHVDFSSEVSTAVRITDGALVLVDAVEGVCIQTHAVLKQAYQEKVKPCLVLNKIDRLILELHMTPLEAYQHLSKIIEQVNVITGTLTSEEIILKESSEDYIESSDDSNLNFNENIGTEYYFSPQKGNVAFTTAFDGWGFTIKQFIDLCYKKTGIKKEILEKCLWGEYYYHPKEKKIYKSPKGNLMPMFVTFILNSVWEVVKTIVGTPEWIDRDRLDKMISVLNITVGARDLASKDQKIVLKSVLHAWLPLSEAVLSMVCDKLPDPIEGQARRMEKIFKPSKSLSTSSSSSSSSSNQSNVELIEKQKQLLYDTITCNSSDDCEIVAYVAKVFAHNKRGGVQTSTIHRPVPPRRVQPSAVPSQNRQQQLHQDEKDILKIDNMFISSAPSTTNDSTTTTKTTTTSPSSPITSTAKPLDLSTIPTGPIKANNNDEEFIAVVRVFSGVLKKGKTIYVMGPRYDPMNPTHDVYKVEITHLYLLMGSSLEPIDKVPAGNVCGVGGGVGNLVLKSATISSSLMCPPISNMMFVSSPIVKVALEPENISDLPKLLHGLKLLNQADPLVEVYVQETGEHVIVASGELHLERCIRDLKESFAKINVHVSSPIVPFRETIITPTITTPTTSSTITSSSSTTAAATATTTNNSGQQSPPLKEIITVKTANKKVSVKIRAIPLPKNITNLIEQRSQQLRDLFLGGKNTNKELSDNKITKREAEQAEREDFQKELEEELEKSGGDWKNEIKNIWSFGPRHIGPNLLLNHIPGYNLSPYWKHSLQRGIQKKLKKLQKQQQQEKEEIKEEEEEKEEEEKEDEEDEDEKEIEEEEIQEEENSNSEVGSIKLLDGDDKFKRISELDNSIVSGFQLATIAGPLCDEPMMGVCLIVEDIDIIREEGDQQNSDSYGPLSGQMISTVKEGCRMAFQIKPQRLMEALYLCEIQVTSTALGKMYSVLSSRRAQIQKEGVKEGTQIFCIQARLPVVESFGFSQQIMIKTSGAASTQLFFDNYWETIEQDPYYEPTTEEELEDNGVNIASLGNNIARQYMNMIRKRKGLFVEEKLVEHADKQRTLKKNK
Protein: Phosphoinositide phospholipase C 1 (EC 3.1.4.11) (Phosphoinositide phospholipase PLC1) (AtPLC1) (AtPLC1S) (PI-PLC1) (Q39032)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for secondary responses to abscisic acid signals.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Inositol polyphosphate multikinase beta
- Inositol polyphosphate multikinase alpha
- Type I inositol polyphosphate 5-phosphatase 2
- Phosphatidylinositol 3-kinase VPS34
- Non-specific phospholipase C1
- Phosphatidylinositol-3-phosphatase myotubularin-1
- Phosphatidylinositol-3-phosphatase myotubularin-2
- Multiple inositol polyphosphate phosphatase 1
- Type I inositol polyphosphate 5-phosphatase 1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
Sequence:
MKESFKVCFCCVRNFKVKSSEPPEEIKNLFHDYSQDDRMSADEMLRFVIQVQGETHADINYVKDIFHRLKHHGVFHPRGIHLEGFYRYLLSDFNSPLPLTREVWQDMNQPLSHYFLYTGHNSYLTGNQLNSNSSIEPIVKALRNGVRVIELDLWPNSSGKEAEVRHGGTLTSREDLQKCLNVVKENAFQVSAYPVVLTLEDHLTPILQKKVAKMVSKTFGGSLFQCTDETTECFPSPESLKNKILISTKPPKEYLQTQISKGSTTDESTRAKKISDAEEQVQEEDEESVAIEYRDLISIHAGNRKGGLKNCLNGDPNRVIRLSMSEQWLETLAKTRGPDLVKFTQRNLLRIFPKTTRFDSSNYDPLVGWIHGAQMVAFNMQSHGRYLWMMQGMFKANGGCGYVKKPDVLLSNGPEGEIFDPCSQNLPIKTTLKVKIYTGEGWNMDFPLDHFDRYSPPDFYAKVGIAGVPLDTASYRTEIDKDEWFPIWDKEFEFPLRVPELSLLCITVKDYDSNTQNDFAGQTCFPLSEVRPGIRAVRLHDRAGEVYKHVRLLMRFVLEPR
Protein: Ataxin-10 homolog (Copper transport protein 86) (P25355)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential protein which may be involved in threonine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Increased copper sensitivity protein 3
- General control transcription factor GCN4
Sequence:
MPMNNFLDEFNLFDSIITMMKNDPCCVEDYEPIVENLNRIFQRTFNDEEHRKSMANSQLFWERLRDTLEAMLLPASLNENSSIPYTRTVRGLILMMRNLAAENQEIPQKLLLQNLVIRGFLHATSEYVVDTPLIKHLYIACLTCLFNIQQNYSTVDMTTFPALLQFLQYPYGIKLEDGEEEEHFWLPYLFLFKTYLNNDEFSNEFFRDNDTPQKDYYCVRDRIFFDIVTAKFIQDQENSFLIEKGRNYLDDSKLEITSIDLSVLECISKSLTTASFGKYLNGLEERQPGKFTTLLQILQLVVTSKEDWNTYELTAIMSWCYPILQRLACKDIPAFFNKSCNDYAPSVAIQLHSTLLSCLDIISDLCKFNHVRKFLISYDSVKILVSLLDTFQKNLLRINFLKGNGDTVNEIKITDHEGNKIEDRLLIFNRVNTNESFIRADNFPHCKLVIIEILASLVYAHPEIQDQIRELGGLALILSNCVIDDNDPFIKERSIVCLKFLLKNNAKNQEYVKKMEAQDVVQDDALSKAGFEISVEKGGKVRLVSKEEDPGNENSEIISIDED
Protein: Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) (Q13310)
Organism: Homo sapiens (Human)
Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:8524242}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
Interaction partners:
- Polyadenylate-binding protein-interacting protein 1
- Polyadenylate-binding protein 2
- Eukaryotic translation initiation factor 4 gamma 1
- Ataxin-2
- Ras GTPase-activating protein-binding protein 1
- Polyadenylate-binding protein 1
- Eukaryotic initiation factor 4A-I
- Eukaryotic translation initiation factor 4E
- Probable ATP-dependent RNA helicase DDX6
- Eukaryotic initiation factor 4A-II
Sequence:
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS
Protein: Gamma conglutin 1 (Conglutin gamma 32) (allergen Lup a gamma-conglutin) [Cleaved into: Gamma conglutin 1 beta subunit (Gamma conglutin 1 17 kDa subunit) (Gamma conglutin 1 small subunit); Gamma conglutin 1 alpha subunit (Gamma conglutin 1 29 kDa subunit) (Gamma conglutin 1 large subunit)] (Q9FSH9)
Organism: Lupinus albus (White lupine) (Lupinus termis)
Function: Sulfur-rich seed storage protein that remains undegraded at germination. The uncleaved form exhibits some inhibitory activity against GH11 xylanase from T.longibrachiatum, more at pH 7 than at pH 5.3, but not against GH12 xyloglucan-specific endoglucanase (XEG) from A.aculeatus. Binds to model phospholipid membranes containing dimyristoyl phosphatidylglycerol (DMPG), dioleoyl phosphatidic acid (DOPA) or mixture of dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol (DMPC:DMPG), or mixture of dioleoyl phosphatidic acid and dioleoyl phosphatidylcholine (DOPC:DOPA).
Subcellular location: Secreted, extracellular space {ECO:0000303|PubMed:11406286}. Note=Present in the extracellular spaces of germinating cotyledons and in the young roots. {ECO:0000303|PubMed:11406286}.
Interaction partners:
Sequence:
MAKNMAPILHILVISLSYSFLFVTSSSQNSQSLYHNSQPTSSSKPNLLVLPIQQDASTKLHWGNILKRTPLMQVPVLLDLNGKHLWVTCSQHYSSSTYQAPFCHSTQCSRANTHQCFTCTDSTTSRPGCHNNTCGLISSNPVTQESGLGELAQDVLALHSTHGSKLGSLVKIPQFLFSCAPTFLTQKGLPNNVQGALGLGHAPISLPNQLFSHFGLKRQFTMCLSSYPTSNGAILFGDINDPNNNNYIHNSLDVLHDMVYTPLTISKQGEYFIQVSAIRVNKHMVIPTKNPSMFPSSSSSSYHESSEIGGAMITTTNPYTVLRHSIFEVFTQVFANNVPKQAQVKAVGPFGLCYDTKKISGGVPSVDLIMDKSDVVWRISGENLMVQAQDGVSCLGFVDGGVHTRAGIALGTHQLEENLVVFDLARSRVGFNTNSLKSHGKSCSNLFDLNNP
Protein: Chromodomain-helicase-DNA-binding protein 3 (EC 3.6.4.12) (ATP-dependent helicase Chd3) (O16102)
Organism: Drosophila melanogaster (Fruit fly)
Function: Helicase which acts in nucleosome-remodeling by catalyzing ATP-dependent nucleosome mobilization. Likely to be involved in the regulation of transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:18250149}. Chromosome {ECO:0000269|PubMed:18250149}. Note=During embryogenesis, detected in nuclei before and after their migration to the membrane of the preblastoderm embryo (PubMed:18250149). Remains associated with condensed chromosomes in mitotic nuclei. Not detected in nuclei postgastrulation (PubMed:18250149). In polytene chromosomes of third instar larvae, weakly expressed at the chromocenter and fourth chromosome localizing mainly to the interbands (PubMed:18250149). {ECO:0000269|PubMed:18250149}.
Interaction partners:
- Histone deacetylase HDAC1
- Protein deacetylase HDAC6
- Methyl-CpG binding domain protein-like, isoform C
- Metastasis-associated protein MTA3
- Charon
- CDK2-associated protein 1, isoform B
- Chromatin assembly factor 1 p55 subunit
- Simjang, isoform E
- Chromodomain-helicase-DNA-binding protein Mi-2 homolog
- Protein zwilch
Sequence:
MSSKRGADPDWKTPGKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLCCDSCPSVYHRTCLSPPLKSIPKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSNQYPSPNRATPSSIVLM
Protein: Holo-[acyl-carrier-protein] synthase, putative (EC 2.7.8.7) (Q8I1N7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Dephospho-CoA kinase, putative
Sequence:
MIFVLIFSKLKGAFYKILKLLCLYLFLYEEEYVLFYGKVKSLNTKTNAECTYVGMRKGLRVKPFKNIKDKNGLNILSSFCKRNDITCFNKINNFFCIGKNRFFRKRDILFYSYIIQNMFMKRIYMNKGKRNTYYLINEHMKNDEYIDCNRRKYKKKLFNIYMEYNNMLYEEGDNFYDNYKSNSFLEINNNQVNIPIDLSRFEKEVRKLIEILNYKNFHLNITFVSLEEMKRINKKHRNKDMATDVISILHYLDDPNYDYNYDFLKNAIGGKKGFKSGDIYLCPEYINRECFLSRMNYEKSLLDKKGDSLEYVSEMKKNVTDETFEDITEGSINRTSCNVYDISVDDNDVGITSFDKVSKNVDTNKILNPRGVNKLFSNIFSVNERLPFYVLHGFVHLMHKDHENNVEEYNEFMDIEENIIKKYMTFNKYTPTFYAHYIIGLGTDILCVYRIYKILLLKNKNKFLQKVLNSLEYKELIQQDDTIKYNIEKLAIYISKKFAAKEAIVKSIGRGLSSISKYGISMNDIEIRNDKYGKPHVYLYNKAKKIARQLGIVKIFLSISDEKIFNNNIKINNVNKKNFTCLIHAQALAVGSNI
Protein: p-GlycoProtein related (Q22655)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEESSNDYTTPLIAQSNEKKPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQASFNCAQLT
Protein: Uncharacterized J domain-containing protein C63.13 (Q9Y7T9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome-associated molecular chaperone sks2
- Thioredoxin-like protein 1
- Endoplasmic reticulum chaperone BiP
- Heat shock protein homolog pss1
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- Probable heat shock protein ssa2
- Probable heat shock protein ssa1
Sequence:
MFKDYYAILNITPKASAEEIKYAYKKAALETHPDRVSPSARARATEQFQLVNEAYYVLSDNSRRAQYDRESASSSAKPRQSFFSRTNPQPQSQSQQGGPSFGFRQSFSDSQFEQVFNEMMNETSTRGIANAFWTIVGTLAGAALGFITFDVPGVLVGSAAGAKLGRIRDTHGKSAYSVFQDMPAVEKARILTQFLSHLLNSSKQFTSS
Protein: Nicotinic acetylcholine receptor alpha4, isoform C (A8JNX5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
- Nicotinic acetylcholine receptor alpha5, isoform I
- Nicotinic acetylcholine receptor alpha6, isoform E
- Acetylcholine receptor subunit alpha-like 2
- Acetylcholine receptor subunit alpha-like 1
- Nicotinic acetylcholine receptor alpha3, isoform B
- Wing blister, isoform B
- Proteasome subunit beta
- Nicotinic acetylcholine receptor alpha7, isoform E
- Importin subunit alpha
Sequence:
MVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFSGTSAGRCRPPQ
Protein: 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) (Q9NRX4)
Organism: Homo sapiens (Human)
Function: Exhibits phosphohistidine phosphatase activity.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Intermediate conductance calcium-activated potassium channel protein 4
- Nucleoside diphosphate kinase B
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Sequence:
MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKVSGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTWANDGY
Protein: GH27195p (Q9VDZ5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM44
- 28S rRNA
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Methionyl-tRNA formyltransferase, mitochondrial
- Nucleolar complex protein 2
- Probable rRNA-processing protein EBP2 homolog
- Ribosome biogenesis protein BOP1 homolog
- RRM domain-containing protein
- LD47540p
- Nucleolar GTP-binding protein 1
Sequence:
MGKKNRKQQHVDVVPATTDDSPAVIDSPVEHHTQQEDTSAEVFLWLLAYSVLMFTLPFLGFYGVRSWLQESFPHLDLFTVNCWSVLTAVVVVNLVVAMYVLKAFREKPPPPLEPVQQDEDDEPEAAEPKKEQ
Protein: Proteasome subunit alpha type-5 (Macropain subunit PUP2) (Multicatalytic endopeptidase complex subunit PUP2) (Proteasome component PUP2) (Proteinase YSCE subunit PUP2) (P32379)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Proteasome subunit alpha type-3
- 26S proteasome regulatory subunit RPN10
- 26S proteasome regulatory subunit RPN1
- Ubiquitin carboxyl-terminal hydrolase RPN11
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN12
- Proteasome subunit beta type-6
- 26S proteasome regulatory subunit RPN3
- 26S proteasome regulatory subunit RPN5
- Proteasome subunit beta type-4
Sequence:
MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLESDSIEKIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGEGASGEERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHSSLTLKEAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEAAESPEEADVEMS
Protein: Protein LAS1 (P36146)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulates cell surface growth, bud formation and morphogenesis. May act indirectly by regulating factor(s) involved in these processes.
Subcellular location: Nucleus. Mitochondrion.
Interaction partners:
- Polynucleotide 5'-hydroxyl-kinase GRC3
- Pre-rRNA-processing protein IPI3
- Ribosome biogenesis protein SSF1
- 25S rRNA
- Ribosome biogenesis protein ERB1
- Ribosome biogenesis protein NSA1
- Ribosomal RNA-processing protein 1
- Ribosome biogenesis protein MAK21
- Ribosome production factor 1
- ATP-dependent RNA helicase HAS1
Sequence:
MIPPRIVPWRDFAELEELKLWFYPKSKGTIEDKRQRAVQRVQSYRLKGSQYLPHVVDSTAQITCAVLLDEKEACLGVHQDSIPIRLSYVMALIRFVNGLLDPTQQSQFAIPLHTLAAKIGLPSWFVDLRHWGTHERDLPGLEMLRWAANEALSWLYDHYWNDEELEDDRDDDDDDDDTGYGYRRNDKLEKYMESLTKTLDKWKRLRNEFLEYKWVWENANDSLITSSNFSGDNLVNYDAEKRKSSHASSSETMIRENLRQWQELWKLSIYHNVVLEKFFNNYDPLLLKVLMLNLNNFDWKVIEWVARNYRTQQDDSNITTILKRKFNAWKELQKRLLDVIINNLNNKNFKNKWQNWEKLIDENASYLILYFCQSMLAKLETEKITGNSWRNKKRRKQIDSTVEIEAKLKENIDNLSLRFNEGEIKLYDFIPAEKDSVPLKKEVSPALKADTNDILGDLASLKQRMSSFGTVGKKNKQEENRATPVKNWSRVQNWKPKPFGVL
Protein: Response regulator (Q9ZQW0)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MAAAAPAPASVAPSSAPKATGDSRKTVVSVDASELEKHVLAVDDSSVDRAVIARILRGSRYRVTAVESATRALELLALGLLPDVSMIITDYWMPGMTGYELLKCVKESAALRGIPVVIMSSENVPTRITRCLEEGAEGFLLKPVRPADVSRLCSRIR
Protein: Pcdh1 protein (Q8QZT6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
APYLRVDGKTGDIFTTETSIDREGLRECQNQIPGNPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLATDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPTYEAELSENSPIGHSVIQVKANDSDQGANAEIDYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGATPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSITEVAFPENNKPGEVVAEVTASDADSGSNAELVYSLEPEPAAQGLFTISPENGEIRVKTSLDREQRDSYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPFITAPSNTSHRLLTPQTRLGETVSQVTAEDIDSGINAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLVHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKAAKGSKSKGKKSKSPKPVKPVEDEDDTGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQVGQPFRLSTPQPPPHPYHGAIWTEVWE