wanglab/gogpt-training-data huggingface dataset:
Protein: Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Q5RHB5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: A maternally expressed membrane and cytoskeletal linker protein, which is essential for attachment of the centrosome to the male pronucleus. Promotes male and female pronucleus congression and subsequent fusion after fertilization. Congression is mediated by the sperm aster microtubules.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22542100}; Single-pass type IV membrane protein {ECO:0000269|PubMed:22542100}. Nucleus envelope {ECO:0000269|PubMed:22542100}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22542100}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22542100}. Chromosome {ECO:0000269|PubMed:22542100}. Note=Localized at both male and female pronuclear membranes during pronuclear congression and fusion. Colocalized with tubulin at the centrosome adjacent to the nuclear membrane. At prophase is localized at the centrosome on opposite sides of the zygotic nucleus and at the reforming nuclear membrane. At metaphase is juxtaposed with the centrosomes at the mitotic spindle poles. During chromosome segregation is localized with the chromatin. Undetectable at the centrosome at the onset of anaphase, but becomes again apparent by late mitosis.
Interaction partners:
- DEAH
- Spindle assembly abnormal protein 6 homolog
Sequence:
MDVGVTPRRHNPVDSICRKLQTIQRRDQEINSPFQIPKFQTNSYDSPHSGLRFNLEAILKKHTVRPDDSDSASSAGMLTPTASPGPGSSCNTPRAPITPVNATYSITSTLGTLGTIGDRRTSGTYSRPFRRNCSTPSAQTGDNYFNFTPRYSTQSQGPDTDVRTSKIPTPGLFSYNLNFSSDISNMDSELAYPALVVKRLSLGEGSLFTSEPKKESMAEVSLICEEDLLDTIFQACDTQCRGKVYVSHIVDFLRHTTCRSSEDSGLEELCNMLDPERKDISIDLDTYHAIMKEWIEDCRNQGKDLKNDTQQESSKLRDSLSAKRSALLNMTSGSLEAFGGEASRADLETSDLVFCVADLQLNNQKLQEEVRKLKQAVENMEDTNQKLIEENEELKTQAKMGQQLLQKEKMLKEEVEEMKLSLTSSEESRAQAAAQRKQMERENQSLISKIAALQEENMKVTLEAEELQKKMNDLCDLNADLQVQIHSFDAILADKESLIQEKNKQMDELKVAVVEYSSVTELLRADKNKLESQMQMMQPDVTIPGLSLSVAYRLNQTSSGSLQTELALAQNPLEGLEHLSTSVCFASSLDETLDREVLLLLQGPTPEQLSLEFKSLISRLKREFKEDGLTFLTAIRSLTENSETQEANTDLKMQGLEVQLEQRRTDWIRSLEQLDQYRDSLERELLKMASNMRRSRTEILHLSVKVQEQENQKQQLREEVDRLKTPLDNREASSQTPDHLQQVVEELDGPSLEWDEEYVLSESPPLQELGPDQQMLEELCCDEEVLQALKQEEEEPTETVSDKEKITAKSEGEGEATYDSGVENEEPQRDFTLSHMCLPDKKSERESNEAPFVGEGGEQRPCMSLKEEDRLPECTGPEDAHEQAAPLPHTHCECAGDQPLTYDNLEVTSVKDHILSTEPSSLMTCELVSPSTGHPEVGNSITGRTEQLVGTNGEPEEERLTTGADMSDLQRLGEGQLSKVSAKSDKSLLLPVAEEEEAMPEAVEVTSAGVNSPDKHKTGSKKTVVTSDSNSTGSADSLKDPSEKVKDMTFDPAASEDNIPTVPATQSPKKDPLASRNKLKKEMSSMEVIEEQKAQEDGEPTVVTEKEGDTSVSSENASDSTKDDKNSLSPSDKEIEAEFHRLSLGFKCDMFTLEKRLRLEERSRDLAEENVRKEVISCKALLQALIPRCEEDNQSMEIIHRVQKNLEILVQSMTRVSSRSEMLGAIHQETRVGKTVEVMIQHVENLRRMYTKEHAELLELRENLTPNERSFGSHSERDDFRNKKQTTSNIFKTTSRRISIATIPRSIGGQTHFDMPKDMAETEVERLSRRSPWNMAAKRPPLKRFVSSGTWADIDEPTLMNSPTPSPTDNAPPSLMEGRPAVSRGARGIWIWVALFVVLAVLLALLASLMLQPAVDAAPVGTGDSWMTIQQLLWPYTGLRHNGQPPV
Protein: Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) (Q9BSL1)
Organism: Homo sapiens (Human)
Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10857748, ECO:0000269|PubMed:15531880}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF123
- Endosialin
- Vimentin
- Importin-8
- Mitochondrial inner membrane protein OXA1L
- Calmodulin-regulated spectrin-associated protein 1
Sequence:
MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT
Protein: Microtubule End Binding Protein (Q9GRZ1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Zygote defective protein 9
- CAP-Gly domain-containing linker protein 1 homolog
- Kinesin-like protein
- Kinesin-like protein
- Exchange factor for Arf-6
- Tubulin beta-2 chain
- Regulator of spindle assembly protein 2
- AP complex mu/sigma subunit domain-containing protein
Sequence:
MGYQVVNVYTTASSADNLSRHEMLMWVNDCLQAHFTKIEQLHTGAGYCLFTDFLFPDSIQLKKVKWNSRLELDWLSNWKLVQTTWKNLGVEKVIPVDKLIKGKFQDNFEFLQWFKKLFDANYDGHEYDPMQARNGEGLPTEGGPAAGASAKTPSRMPARSVPQKPVTTMRTPAATPAAPPTRPTPSRSSAAPRATAPTPTAAPPKTCAPPVRSASTVAAAAAAAPPGVDMATFNKLKEELEEVTRQLTESDNVIASLEKERDFYFSKLRTIEVICQDNESIGNVEVNRVLEVLYETEEGFAPPEDEANGGAEAEEF
Protein: Poly(3-hydroxyalkanoate) polymerase subunit PhaE (PHA polymerase) (ORF2) (PHB synthase subunit PhaE) (Poly(hydroxyalkanoic acid) synthase subunit PhaE) (PHA synthase) (Polyhydroxyalkanoic acid synthase) (Poly-beta-hydroxybutyrate polymerase subunit PhaE) (PHB polymerase) (Poly(3-hydroxybutyrate) polymerase) (P45372)
Organism: Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) (Chromatium vinosum)
Function: Polymerizes D(-)-3-hydroxybutyryl-CoA to create polyhydroxybutyrate (PHB) which consists of thousands of hydroxybutyrate molecules linked end to end. This subunit has no catalytic activity but enhances the activity of PhaC, the catalytic subunit, 100-fold.
Subcellular location: Cytoplasm {ECO:0000305}. Note=Associates with poly(3-hydroxybutyric acid) granules (PHB) when grown under 'storage' conditions. {ECO:0000269|PubMed:7957260}.
Interaction partners:
- Poly
- Acetoacetyl-CoA reductase
- Acetyl-CoA acetyltransferase
- Uncharacterized protein Alvin_0064
- General secretion pathway protein J
- Uncharacterized protein
- General secretion pathway protein M
Sequence:
MSNTNFFNDDWLELQRKYWDNWTDMSRKAMGLDSASSSATTPWEAAIDQWWKAMAPAAPDLSRSFMEKMMEQGKNFFRLADTFAKRADEGNAGNGLELWTKTLEDMQKRFSGSLDDGGNTMQRLMSFWELPLDNWQRMMSSMSPMPGDMLRNMPHEQFKDSLDRALSAPGLGYTREEQSQYQELMRSAMEYQAALQEYTNVYTKLGMKSVEHMGSYIQGVIDSGKTIDSARALYDNWVACCEGAYADEVATPEYARIHGRLVNAQMALKKRMSILVDENLGALNMPTRSELRTLQDRLQETRRENKALRHSLHSLERRVAALAGEEPATKPATALRSPAPAAKAPARRRTTKTNPAD
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q40640)
Organism: Oryza sativa (Rice)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MISLPLLLFVLLFSALLLCPSSSDDDGDAAGDELALLSFKSSLLYQGGQSLASWNTSGHGQHCTWVGVVCGRRRRRHPHRVVKLLLRSSNLSGIISPSLGNLSFLRELDLGDNYLSGEIPPELSRLSRLQLLELSDNSIQGSIPAAIGACTKLTSLDLSHNQLRGMIPREIGASLKHLSNLYLYKNGLSGEIPSALGNLTSLQEFDLSFNRLSGAIPSSLGQLSSLLTMNLGQNNLSGMIPNSIWNLSSLRAFSVRENKLGGMIPTNAFKTLHLLEVIDMGTNRFHGKIPASVANASHLTVIQIYGNLFSGIITSGFGRLRNLTELYLWRNLFQTREQDDWGFISDLTNCSKLQTLNLGENNLGGVLPNSFSNLSTSLSFLALELNKITGSIPKDIGNLIGLQHLYLCNNNFRGSLPSSLGRLKNLGILLAYENNLSGSIPLAIGNLTELNILLLGTNKFSGWIPYTLSNLTNLLSLGLSTNNLSGPIPSELFNIQTLSIMINVSKNNLEGSIPQEIGHLKNLVEFHAESNRLSGKIPNTLGDCQLLRYLYLQNNLLSGSIPSALGQLKGLETLDLSSNNLSGQIPTSLADITMLHSLNLSFNSFVGEVPTIGAFAAASGISIQGNAKLCGGIPDLHLPRCCPLLENRKHFPVLPISVSLAAALAILSSLYLLITWHKRTKKGAPSRTSMKGHPLVSYSQLVKATDGFAPTNLLGSGSFGSVYKGKLNIQDHVAVKVLKLENPKALKSFTAECEALRNMRHRNLVKIVTICSSIDNRGNDFKAIVYDFMPNGSLEDWIHPETNDQADQRHLNLHRRVTILLDVACALDYLHRHGPEPVVHCDIKSSNVLLDSDMVAHVGDFGLARILVDGTSLIQQSTSSMGFIGTIGYAAPEYGVGLIASTHGDIYSYGILVLEIVTGKRPTDSTFRPDLGLRQYVELGLHGRVTDVVDTKLILDSENWLNSTNNSPCRRITECIVWLLRLGLSCSQELPSSRTPTGDIIDELNAIKQNLSGLFPVCEGGSLEF
Protein: Disks large homolog 3 (Synapse-associated protein 102) (SAP-102) (SAP102) (P70175)
Organism: Mus musculus (Mouse)
Function: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2A
- Disks large homolog 4
- Disks large homolog 2
- Voltage-dependent calcium channel gamma-2 subunit
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor 1
- Glutamate receptor 2
- Neurobeachin
- E3 ubiquitin-protein ligase NEDD4
Sequence:
MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIFDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL
Protein: Dwarfin sma-3 (MAD protein homolog 2) (P45896)
Organism: Caenorhabditis elegans
Function: Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21408209}. Nucleus {ECO:0000269|PubMed:21408209}. Note=In males localizes to the nuclei and cytoplasm during tail tip morphogenesis (PubMed:21408209). In hermaphrodites localizes only to the cytoplasm during tail tip morphogenesis throughout the L4 stage (PubMed:21408209). {ECO:0000269|PubMed:21408209}.
Interaction partners:
- Dwarfin sma-4
- Dwarfin sma.
- Serine/threonine-protein kinase receptor sma-6
- Mitogen-activated protein kinase mpk-1
- Dwarfin sma-2
- Protein dbl-1
- Smad-related protein daf-14
- TGF-beta family profile domain-containing protein
- Ski protein homolog
- FYVE-type domain-containing protein
Sequence:
MNGLLHMHGPAVKKLLGWKIGEDEEKWCEKAVEALVKKLKKKNNGCGTLEDLECVLANPCTNSRCITIAKSLDGRLQVSHKKGLPHVIYCRVWRWPDISSPHELRSIDTCSYPYESSSKTMYICINPYHYQRLSRPQGLNSSMPSPQPISSPNTIWQSSGSSTASCASSPSPSVFSEDGGEVQVHQRPPPFRHPKSWAQITYFELNSRVGEVFKLVNLSITVDGYTNPSNSNTRICLGQLTNVNRNGTIENTRMHIGKGIQLDNKEDQMHIMITNNSDMPVFVQSKNTNLMMNMPLVKVCRIPPHSQLCVFEFNLFFQMLEQSCNDSDGLNELSKHCFIRISFVKGWGEDYPRQDVTSTPCWLELRLNVPLAYIDQKMKQTPRTNLMEPNSMT
Protein: ZW10 interacting kinetochore protein (cDNA FLJ36489 fis, clone THYMU2018126, highly similar to ZW10 interactor) (cDNA FLJ60420, highly similar to ZW10 interactor) (A6NH27)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEVRERKTGTQQELDRVFQKLGNLKQQAEQERDKLQRYQTFLQLLYTLQGKLLFPEAEAEAENLPDDKPQQPTRPQEQSTGDTMGRDPGVSFKAVGLQPAGDVNLP
Protein: Homeobox protein Hox-D1 (Hox.lab1) (Labial protein) (Xlab) (Q08820)
Organism: Xenopus laevis (African clawed frog)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Acts downstream of meis3 to pattern the hindbrain.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MNSYLEYTSCGDVLAFSPKFCRSDHRNMNLQPYPRSGADHSFMPVGGVPGSVAHQAPHQSPALYAPCSLDVAYEPTPPSDYSFLHSSPDYDYYGSNHQIEETGGHIPYGSSLFPGNGSYILNGQLSYRTLGEETQMAQCKEPLEVYPGGNLQSISPSPGTYPKPASPASDSYVSTFDWMKVKRNPPKKSIPSEYGVTSPPCNVRTNFTTKQLTELEKEFHFNKYLTRARRIEIANSLQLNDTQVKIWFQNRRMKQKKREREGTLPNSPPSGPASNFCVKPPHLKSVNETATLSPSKDASP
Protein: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Malate dehydrogenase [quinone] iron-sulfur subunit) (EC 1.1.5.-) (Q9CQA3)
Organism: Mus musculus (Mouse)
Function: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9YHT2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9YHT2}; Matrix side {ECO:0000250|UniProtKB:Q9YHT2}.
Interaction partners:
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
Sequence:
MAATVGVSLKRGFPAAVLGRVGLQFQACRGAQTAAAAAPRIKKFAIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA
Protein: Uncharacterized protein C10orf67, mitochondrial (Q8IYJ2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
Sequence:
MMALVRDRRAHYVMSIVIRWVHCFSSSLRGTFGTRWEAMKAKATELRVCCARRKREAREFKPPQMRGSTRLNISDDLKIGFFSTDHATQTDSSEILSVKELSSSTQKLAQMMKSLQVDFGFLKQLLQLKFEDRLKEESLSLFTILHDRILEIEKHYQQNEDKMRKSFNQQLADAIAVIKGMYQQFFEVEEENVSLQDASTVKTNILLRKLKEKEEVIKELKEELDQYKDFGFHKMESFAKETSSPKSNLEKENLEYKVENERLLQIISELEEEIQINLKENSGLEDELISMKEMAEKDHKTIQKLMDSRDRLREELHYEKSLVQDVINKQKEDKEMRKKYGSLSVKVARSAKGREASLSPWPKSPPSTTALRPHSATMSVSSAGAQKAKMPKKALKEDQAVVEDKHGLESQIEALKANLENEKKKVERFRKEADRLNKSWEKRFFILRNSFHVLKNEMFTRHTLFRQFAVLADTSFNYIKVKPLLVQSRTTMTAISSSSHCTSSIDGKHVDVVSDQAALQLSPKGKLSESPKEESLEEPSMRQSSPAETVD
Protein: Small ribosomal subunit protein mS33 (28S ribosomal protein S33, mitochondrial) (MRP-S33) (S33mt) (Q9Y291)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123}.
Interaction partners:
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS21m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS3m
Sequence:
MSSLSEYAFRMSRLSARLFGEVTRPTNSKSMKVVKLFSELPLAKKKETYDWYPNHHTYAELMQTLRFLGLYRDEHQDFMDEQKRLKKLRGKEKPKKGEGKRAAKRK
Protein: MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Q6PFL1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGVIRRLDETVVNRIAAGEIIQRPANAIKEMMENCLDAKSTNIQITVKEGGLKLILIQDNGTGIRKDDMEIVCERFTTSKLKSFDDLSSIATYGFRGEALASISHVAHVTITTKTADAKCAYRANYCDGKLKSPPKPCAGNQGTLISVEDLFYNVSTRRKALKSPSEEYSRIVEVVSRYAIHNSGKSFSVKKQGEMVADVKTLPNASVLDNIRVVFGVAVSRELIEVECEDQKFAFKVKGYISNANYSVKKCILILFINHRLVESSALKKAIETVYTAYLPKNTHPFLYLSLEIAPQNIDVNVHPTKHEVHFLHEDSIIESIQKHIENKLLGSNSSRTYFTQTLLPGLSASASVAKASSSSADPQERVYAHQMVRTDSKAQKLDAFLQPSASSSSSAAQRKTEKTSSTSTAVQDSVELDDAELLTAADVEPCGGEDPQTDAQPPGDEAPPRKRPHVEEVKEDLTAASLPRRRIVKLTSIKGLRDQIELQTHKGLQELLQNHSFVGSVSPQWTLVQHQTKLYLLNTTKLSQELFYQILIYDFGNFGVLRLSNPAPLYDLAMLALDSEESGWTEEDGPKEGLAQYIVDFLKQKAEMLEEYFSLEIDAEGNLTGLPMLLDNYTPAMEGLPMFILRLATEVNWDKEKECFREFSVECSHFYSIRKSYTLEADADEPQDAEMSWQWKVEHVLFKALRSLFSPAKHLSEDGSVLQIASLPDLYKVFERC
Protein: Desmocollin-3 (P55850)
Organism: Mus musculus (Mouse)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome {ECO:0000269|PubMed:38395410}.
Interaction partners:
- Junction plakoglobin
- Desmoglein-3
- Plakophilin-1
- Desmoplakin
- Desmoglein-1-alpha
- Plakophilin-3
- Desmoglein-2
- Plakophilin-2
Sequence:
MVVPEFRSPQCRALCTKLLLTLWVFSFVGEACKKVTFHVPSTLEADKIIGRVSLKECLSSADGIMPSDPDFRVLDDGSVYPTRAVVLSDEKRSFTIQLSDSKMQTQKEIPVILEHKKKVLKKRHTKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR
Protein: Gap junction alpha-5 protein (Connexin-40) (Cx40) (P36382)
Organism: Homo sapiens (Human)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
- Gap junction alpha-1 protein
- Gap junction gamma-1 protein
- Gap junction alpha-4 protein
- Gap junction beta-2 protein
- Gap junction beta-1 protein
- Sodium channel protein type 5 subunit alpha
- Homeobox protein Nkx-2.5
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
- NF-kappa-B inhibitor alpha
- Gap junction alpha-8 protein
Sequence:
MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGSGSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV
Protein: Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) (P35221)
Organism: Homo sapiens (Human)
Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26231}. Cell junction, adherens junction {ECO:0000269|PubMed:25653389}. Cell membrane {ECO:0000250|UniProtKB:P26231}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:P26231}. Cell junction {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:16184169}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF8}. Nucleus {ECO:0000269|PubMed:16184169}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. {ECO:0000250|UniProtKB:P26231}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21708131}; Peripheral membrane protein {ECO:0000269|PubMed:21708131}; Cytoplasmic side {ECO:0000269|PubMed:21708131}.
Interaction partners:
- Catenin beta-1
- Vinculin
- Cadherin-1
- Catenin delta-1
- Junction plakoglobin
- Cadherin-2
- Tight junction protein 1
- Afadin
- Cadherin-17
- Catenin alpha-2
Sequence:
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI
Protein: Glutathione S-transferase-like protein tpcF (EC 2.5.1.-) (Trypacidin synthesis protein E) (Q4WQZ2)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin. Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin. Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death. The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway.
Interaction partners:
- Glutathione reductase
- Glutathione synthetase
- glutathione-specific gamma-glutamylcyclotransferase
- Oxidoreductase tpcG
- Decarboxylase tpcK
- Oxidoreductase tpcJ
- Anthrone oxygenase tpcL
- O-methyltransferase tpcA
Sequence:
MPDIQPITVYGKGGPNPPRVAIILAELDLPHKVIEVPLSKVKEPDYVAINPNGRIPAIYDPNTDLTLWESGAIVEYLVSHYDPDHRISFPAGSNLAALATQWLFFQASGQGPYYGQASWFKKFHHEKVPSAIERYVKEINRVTGVLEGHLSRQKVAADGDGPWLVGGKCSFADLAWIPWQVIVTAIIQPEDGYTVEDYPHVKNWLDRMMARPGVQKGMADIFPST