Protein: MAX gene-associated protein (A2AWL7)
Organism: Mus musculus (Mouse)
Function: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein max
- Transcription factor E2F6
- Lethal
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 6
- Transcription initiation factor TFIID subunit 1
- WD repeat-containing protein 5
- YY1-associated factor 2
- KAT8 regulatory NSL complex subunit 1
- Histone-lysine N-methyltransferase 2A
Sequence:
MEEKQQIILANQDGGTVTGGAPTFFVILKQPGNGKTDQGILVTNRDARALLSRESSPGKSKEKICLPADCTVGKITVTLDNNSMWNEFHNRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDISPVDSHRYKWNGRWWEPSGKAEPHILGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLSSKPQREGKQRNSSDQEGNSVSSSPAHRVRLTEGEGSEIHSGDFDPVLRGHEASSLSLEKAPHNVKQDFLGFMNTDSTHEVPQLKHEISESRIVNSFEDDSQISSPSNPNGNFNVVIKEEPLDDYDYELGECPEGITVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNLEADHPSYKWLPNSPGVAKAKMFKLDAGKMPVVYLEPCAVTKSTVKISELPDNMLSTSRKDKSMLAELEYLPAYIENSDGTDFCLSKDSENSLRKHSPDLRIVQKYTLLKEPNWKYPDILDNSSTERIHDSSKGSTAESFSGKEDLGKKRTTMLKMAIPSKTVTASHSASPNTPGKRGRPRKLRLSKAGRPPKNTGKSLTAAKNIPVGPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTTEEPSSLQTTTTNDSGCRTRISQLEKELIEDLKSLRHKQVIHPALQEVGLKLNSVDPTVSIDLKYLGVQLPLAPATSFPLWNVTGTNPASPDAGFPFVSRTGKTNDFTKIKGWRGKFQNASASRNEGGNSEASLKNRSAFCSDKLDEYLENEGKLMETNIGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSHSVKPQSVTTASRKTKAQNKQTTLSGRTKSSYKSILPYPVSPKQKNSHVSQGDKITKNSLSSTSDNQVTNLVVPSVDENAFPKQISLRQAQQQHLQQQGTRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFHKKAANRDPLFYDTLGEEGREGGGVREDEEQLKEKKKRKKLEYTVCEAEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPIKPLVLPQPDLSSTTKGKLTPGIKPARTYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEEQRQLSPPLSPSSSFQQQSSCYSSPENRVTKELDSEQTLKQLICDLEDDSDKSQEKSWKSSCNEGESSSTSYVHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKCRGEKTPPVYSSRVKISMPSSQDQDDMAEKSGSETPDGPLSPGKMDDISPVQTDALDSVRERLHGGKGLPFYAGLSPSGKLVAYKRKPSSTTSGLIQVASNAKVAASRKPRTLLPSTSNSKMASSGPATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTPQPLTGPQKFSIRPSPVMVVTPVVSSEQVQVCSTVAAAVTTSPQVFLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFAKPLVASPTITLPVASTASTSIVMVTTAASSSVVTTPTSSLSSVPIILSGINGSPPVSQRPENAPQIPVTTPQISSNNVKRTGPRLLHPNGQIVQLLPLHQIRGSNAQPSLQPVVFRNPGSMVGIRLPAPCKSSETPSSSASSSAFSVMSPVIQAVGSSPTVNVISQAPSLLSSGSSFVSQAGTLTLRISPPETQNLASKTGSESKITPSTGGQPVGTASLIPLQSGSFALLQLPGQKPIPSSVLQHVASLQIKKESQSTDQKDETNSIKREEETKKALPSKDKALDSEANIMKQNSGIIASENTSNNSLDDGGDLLDEETLREDARPYEYSYSTGSHTDEDKDGDEDSGNKNQNSPKEKQTVPEVRAGSKNIDIMALQSIRSIRPQKCVKVKVEPQEGSDNPENPDDFLVLSKDSKFELSGNQVKEQQSNSQAEAKKDCEDSLGKDSLRERWRKHLKGPLTQKYIGISQNFNKEANVQFFTEMKPCQENSEQDISELLGKSGTIESGGVLKTEDGSWSGISSSAAFSIIPRRATKGRRGSRHFQGHLLLPREQMKPKQQTKDGRSSAADFTVLDLEDEDEEDEKTDDSLDEIVDVVSGYQSEEVDVEKNNYVDYLEDDEQVDVETIEELSEEINFPYKKTTATHTQSFKQQCHSHISADEKASEKSRKVSLISSKLKDDCWGDKPHKETEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKLGSDEFCVSPRIGTQLEGSSASSVDLGQMLMNNRRGKPLILSRKRDQATENASPSDTPHSSANLVMTPQGQLLTLKGPLFSGPVVAVSPALLEGGLKPQVASSTMSQSENDDLFMMPRIVNVTSLAAEEDLGGMSGNKYRHEVPDGKPLDHLRDIAGSEASSLKDTERISSRGNHRDSRKALGPTQVLLANKDSGFPHVADVSTMQAAQEFIPKNMSGDVRGHRYKWKECELRGERLKSKESQFHKLKMKDLKDSSIEMELRKVASAIEEAALHPSELLTNMEDEDDTDETLTSLLNEIAFLNQQLNDDSGLAELSGSMDTEFSGDAQRAFISKLAPGNRSAFQVGHLGAGVKELPDVQEESESISPLLLHLEDDDFSENEKQLGDTASEPDVLKIVIDPEIKDSLVSHRKSSDGGQSTSGLPAEPESVSSPPILHMKTGPENSNTDTLWRPMPKLAPLGLKVANPPSDADGQSLKVMPALAPIAAKVGSIGHKMNLAGIDQEGRGSKVMPTLAPVVPKLGNSGAPSSSSGK