wanglab/gogpt-training-data huggingface dataset:
Protein: tRNA N(3)-cytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6) (Q8TCB7)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34268557}. Nucleus {ECO:0000269|PubMed:34268557}.
Interaction partners:
- 18S rRNA aminocarboxypropyltransferase
- 28S rRNA
- Serine--tRNA ligase, cytoplasmic
Sequence:
MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS
Protein: DNA replication licensing factor MCM3 (EC 3.6.4.12) (A0A0S2Z4T1)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368061}.
Interaction partners:
Sequence:
MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
Protein: Musculoskeletal embryonic nuclear protein 1 (Fracture callus protein MUSTANG) (Musculoskeletal temporally activated novel gene protein) (Q80XX4)
Organism: Rattus norvegicus (Rat)
Function: May be involved in the development and regeneration of the musculoskeletal system.
Subcellular location: Nucleus {ECO:0000269|PubMed:14718386}. Nucleus {ECO:0000250|UniProtKB:Q99JI1}. Cytoplasm {ECO:0000250|UniProtKB:Q99JI1}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q99JI1}. Note=Secreted from smooth muscle cells into the muscle extracellular space. {ECO:0000250|UniProtKB:Q99JI1}.
Interaction partners:
Sequence:
MSEAGTPEAPIKKKRPPVKEEDLKGARGSLSKNQEIKSKTYQVMRDYEQAGSAAPSIFSRNRTGTETVFEKPKEGPAKSVFG
Protein: Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (P59267)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses. In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors. Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons. Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane (By similarity).
Subcellular location: Postsynaptic density {ECO:0000250|UniProtKB:Q9JKR5}. Postsynaptic recycling endosome membrane {ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:28768144}; Multi-pass membrane protein {ECO:0000305|PubMed:21471008}. Cell membrane {ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:21471008, ECO:0000269|PubMed:28768144}; Multi-pass membrane protein {ECO:0000305|PubMed:21471008}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UIJ5}; Multi-pass membrane protein {ECO:0000305|PubMed:21471008}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UIJ5}; Multi-pass membrane protein {ECO:0000305|PubMed:21471008}. Note=Translocates to postsynaptic density when synaptic activity decreases. {ECO:0000250|UniProtKB:Q9JKR5}.
Interaction partners:
- Cytoskeleton-associated protein 4
Sequence:
MAPSGSGGVRRRCRRVLYWIPVVFISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIRFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRNPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPVFSSQGDGCSFPTCLVNQDPEQPSTPAGLNSTVKNPENHQFPAKPLRESQSHLLKDSQTWTESSANPGKGKAGMSNPALTMENET
Protein: Prostate collagen triple helix protein (C1QTNF9B antisense RNA 1) (C1QTNF9B antisense gene protein 1) (Q58A44)
Organism: Homo sapiens (Human)
Function: May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15930275}.
Interaction partners:
Sequence:
MWILSNLMGTSEEGNLLSTVSPTVKALFGKTRVSPIFPFSPRSPFQPLIPRTPGSPWGPVGPASPLGPGFPIGPMGPGKPVGPKGPMLPLGPSGPVGPTSPLFPFCP
Protein: Large ribosomal subunit protein mL50 (54S ribosomal protein L13, mitochondrial) (YmL13) (Q02204)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL57
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein bL31m
- Large ribosomal subunit protein mL38
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein mL49
Sequence:
MSSLLKLHCIRPLPQRSVWLSGYKQKARCIHSSAANGDFMSWFKRKKQEEHQEPVKDTKQLIKDIEEGTNEASSQSSSNNKNRLELIPENFIGEGSRRCKRQKELKLAVSSAPFNQWLSRDKITSDNQLDDMILQATEKTLGKVDQDVQFSDLVAKFQFTKFLQSKSGYLIPDYELTTLSTPLQFKRYIKEKILPSANDPKLAYKEAEPNAIHPFSDNYASPNIYVVNDVTSKEQKSKYDTIMKEIQKLEDDATRKALETARSA
Protein: Group IV decarboxylase (Q75JL7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- AAA+ ATPase, core domain-containing protein
- Intron-encoded DNA endonuclease ai2a
- Bifunctional protein argC
- Arginase/agmatinase/formiminoglutamase family protein
- Spermidine synthase
- Extracellular superoxide dismutase 3
- Multifunctional protein pyr1-3
Sequence:
MTLDPYSGSVDCRDWKKSAIKKAIEDGIFKEHDYVMLYNLDEFRALAKEACDNLKGLQTMAVKCNPVMSLMKEAIKAGLGAEVASFGELRIAEIAGFEPSKIIFDSPIKTKKELEYALNLGVVINIDNFEELETIESIVSKFSKEKYESLSLGIRVNPQVGAGKLTDLSTGVPTSKFGIGIEHKDKIIDAYVRNKFLKGVHIHVGSQGFEISNISESAVKVMNLVKEINARDDTKSQITFFNMGGGLSVNFESEETSPTFTQYANHMKQLLPELFNGEFLLITEFGRSYWAKCGVVVSTVEYTKSSGDREIAICHAGANMYIRTVYQFPLWRIRVTIFDSNGEYKTGNEKITDIAGPCCFAADVLVKERLLPPIKKDDFIMAHDSGAYMLSSYSHYNLRLAPPIFSFNTTNNTIELIKKGETIEDKINFFS
Protein: Cytochrome P450 monooxygenase iliC (EC 1.-.-.-) (Ilicicolin H biosynthesis cluster protein C) (P0DO32)
Organism: Neonectria sp. (strain DH2)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IliC catalyzes the ring expansion of the tetramate intermediate to the acyclic 2-pyridone intermediate that contains the trans bis-diene chain. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. 8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MITNDLIAQHSLTLTIASSVLLVFLLSRLLRKDATGKAQGCRPVAKRWQWDPILGLDIVLAQIGALKGNYYLPWLIELHSNMPKTFEINFFGKRQIYTSEPDNLKAMTATNFHDFGIEPMRRHTKGSMPFADKGISTVDGKEWEFSRFLLKPFFYREVYTSTDRIEPFADHMMALIPGDGESFNMQSLIQRWFLDLTTNFIFGKPMDALENPDRARITWAMLDVLKGGRLRAQFYMMMWAFNWTWWYKAVAEVHDFINVHIRETYKEIEEREQRIKDGKPVEPERTDLIWYMAWNLRDEELLRSQLCLVFVPNNDTTSIFISNCIWHLARHPEAWEKLRQEVLAHGDAPLTFEALRNMKYLQCVLNETHRLTPNNVTQIRVCLNDSVLPVGGGKNAKEPFFVRKGDVVSITKTVMYRDPEIWGNDAEEFKPERFDGRRVFWEFLPFGGGPRRCPAQMMVQTEAAYMLARLARVYRRIEARDPAPYTAVMRIGPSNKTGVQIAVYK
Protein: Zinc finger protein 143 (Zfp-143) (Selenocysteine tRNA gene transcription-activating factor) (Q5XIU2)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SIX homeobox 5
- RAD21 cohesin complex component
Sequence:
MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQAVTLADGSTAYIQHNSKDGRLIDGQVIQLEDGSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSSLQAVQLEDGTTAYIHHAVQVPQPDTILAIQADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSEGVTSTGLIGENEQEKKMQIVLQGHATRVTPKSQQSGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKAFATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPIEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGDDVLKGSQITYVTGVEGEDIVSTQVATVTQSGLSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPTHDAVISSAGTHSVAMVTAEGTEGQQVAIVAQDLAAFHAASSEMGHQPHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRIASRIQQGETPGLDD
Protein: Thioredoxin superfamily protein (Q8W456)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMIRTALVFVVFFVGTVVQAQLIPPARRDGFLYPPGRKIDRDTILIEAYIDPVCPDCRDAWEPLKLAIDHYGSRVALVLHLIPLPFHDNAFVASRALHIVDTLNANATFNLLEGIFKHQTLFYNSQTQLMSRPAVVEELIKLGTVTLGNSYHSPLKSGFSNSKSDLATRVSFKYSVSRGVSATPTFYVNGFELPGAGSPKDYEGWRDTIDPLVKPQEVDIRDTFLSFLTQPSY
Protein: Rap guanine nucleotide exchange factor 5 (A0A590UJR0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRMAVGSVKMQPPCESPALAAAAAVVAADGPLRRSPSAREPEREQPPASLRPRLRDLPALLRSGLTLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV
Protein: Uncharacterized protein (Q6K8J6)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MAGSGSGSSSGGRKMKSQLSFTAGPPHLSHIAEDGAFPDRAGAEASVPRTFSAGGSSGGGGFSIVGPWEESRDIISTLGGYESQFGGMASTSALEMAGMDRYLQLQHDQVPFKVRAKRGCATHPRSIAERVRTQYHDQNASIFAFAFSSDLDT
Protein: Signal induced proliferation associated 1 like 1 (F5GYF8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
Protein: Transcriptional repressor scratch 2 (Scratch homolog 2 zinc finger protein) (Q9NQ03)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPRSFLVKKIKGDGFQCSGVPAPTYHPLETAYVLPGARGPPGDNGYAPHRLPPSSYDADQKPGLELAPAEPAYPPAAPEEYSDPESPQSSLSARYFRGEAAVTDSYSMDAFFISDGRSRRRRGGGGGDAGGSGDAGGAGGRAGRAGAQAGGGHRHACAECGKTYATSSNLSRHKQTHRSLDSQLARKCPTCGKAYVSMPALAMHLLTHNLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHYRCRQCDKSFALKSYLHKHCEAACAKAAEPPPPTPAGPAS
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q009X7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTTEALEKYCGSIFWNSSFLQREDPDLPVCLEQTVLVWAPLGFLWLCAPWHIAVLCRKATPTKHLSKLYLCKQIVVGLLFLTAIAGLAVTLGEDYGPTRDTTATEKNPWVFYANPILFAVSWILLVLSQEGVRRREGAVDSTTLFLFWLILVVCDVFPFQTLLREALRMGEIPDLPRFCLFYISFGLELIALILSAFADVPREAEDLVKKNPEVGAAFLSRITFNWFNSMVLNGFKRPLVQKDLWELSEAESTLQISQRFLQTMQTELKAARTRLQTKMRKRGEEKASKGQGEGLQNGHQNRLGKGVSQDVLMMEEKGDEKEKKEEKKKKKKEEKEYYPKSWLIPTIATTFKGVLWESAIFKLITDLLSFASPQILKLMISFTMDKSIHTWTGYMYAVLLILVAIFQSLFLQQYFQRCFVLGMKVKTAIMAAVYKKALVVSNDARKESTVGETVNLMSADAHRFNDVVNFIHLLWSCPLQIALAIAFLWIELGPAVLAGLAVMVLMVPINGLLANMSKNVQIENMRYKDKRMKVVNEMLNGVKILKLYAWEPSFQNQVMGIREQELVVMRKFAYLSSVSTYVFSCAPALVSLATFAVSVAVDSENVLDAGKAFTSISLFNILRFPLAFLPMLVAAMVQTSVSKKRLEKFLGGDDLDTNIVRHDPSFNTAVSVCNGTFAWEKHAEPVLKNVSLEIKPGKLVAVVGVVGSGKSSLISAMLGEMHSPKGFINVQGSVALVPQQAWIQNATLRDNILFGYPLEDSRFQATLEACALGPDLELLPGGDQTEIGEKGINLSGGQKQRVSLARAAYSQADVYLLDDPLSAVDSHVGKHLFEEVVGPKGILKDKTRILVTHGVSFLPYVDEIVVLKEGCVSEVGSYQSLKDSKGAFSEFLDTYAKDEGKKHTDPTSDGEEVGLVPDLQDPQADTPPEDIVSMTLRRESSIRRSQRNGSVRLRKNSSLKKPKPPADDETKKGQRLIEKETMETGQVKFSVYLQYLRAMGWYSTMFFLVYFIQNVAFIGQNLWLSDWTNDAEDYYNKTYPNWKRDTRIGVFGALGVAQGVFVFMGTLLLANGSINASRILHSRLLNNILRVPMMFFDTTPSGRVVNRFAKDIFTVDEAIPQSFRSWIMCFLGVLGTLFVICLATPIFTAIIIPLAVVYYFVQRFYVASSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEKIIDENPKSVYLWIISNRWLAIRLEFLGNLVVFFLALLAVIARDSLDSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVSEYTEMENEADWVSGIRPSEKWPEAGRLRFENFKVRYRPELDLVLHGITCDIDSTEKIGIVGRTGAGKSSLTNCLFRIIEAAEGRILIDGTDIATLGLHDLRTRLTIIPQDPVLFSGALRMNLDPFETFSDEEIWRVLELSHLKEYVGGLQEGLTHEVSEGGENLSIGQRQLLCLARALLRKSRILILDEATAAVDLETDSLIQKTIRREFSHCTVLTIAHRLNTILDRKQVMVLDAGKIVEFDSPSTLFNKQGHFYSMARDAGITTVDSTALDSTALDSTAL
Protein: Uncharacterized protein C3B8.8 (O59716)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- T-complex protein 1 subunit epsilon
Sequence:
MLTQDEVSAQLGQYMLRGYTLLDTICPKCEKVPMMRLRDNPMFCVSCINDLKESDASEHVTVAESAPKIASLPISKTNDAERSQQTTKAPVMERTESSHQATLSVYSRLISELESQLDDRLPLPHNTEFLDVSLQRIERILNLISLAKSLMSS
Protein: Niemann-Pick type C-1a, isoform A (Niemann-Pick type C-1a, isoform B) (Niemann-Pick type C-1a, isoform C) (Niemann-Pick type C-1a, isoform D) (Q9VL24)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- NPC intracellular cholesterol transporter 2 homolog a
- GEO07678p1
- LP12374p
- Niemann-Pick type C-2c
- Niemann-Pick type C-2e
- GEO08227p1
- Niemann-Pick type C-2g, isoform A
- NPC intracellular cholesterol transporter 1 homolog 1b
- SD03967p
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Sequence:
MSPRSPLRISPFGVHILIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARLRYHSQAAAEHETALAGIL
Protein: LD47540p (Lethal (2) k09848, isoform A) (Lethal (2) k09848, isoform B) (Q7K4B2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Probable ATP-dependent RNA helicase DDX56
- Probable ribosome production factor 1
- Ribosome biogenesis protein BOP1 homolog
- Protein MAK16 homolog
- Ribosome biogenesis protein WDR12 homolog
- Ribosomal RNA processing protein 1 homolog
- Putative rRNA methyltransferase
- Probable rRNA-processing protein EBP2 homolog
- Probable ATP-dependent RNA helicase pitchoune
- Ribosome assembly factor mrt4
Sequence:
MKWTTANTKHVNYTAKHELYVGTHTGSFKHLVPASEKTPYGQSNLSDLCALDKDSRVTSLAFGNDDQTEILLGRAKDAVEIHSFTEKGHSRNTVSFNAAPIVGLARYNDKLIAGIGNGEIQSLELEANDESEPVVIATGDQMDHLRQCAQVKSIVATGGKERQNNLKVYDLNADGKQIFTSKNLPNDYLQLEVPVWDSDIGFVDGPSVLATCSRTGYVRIYDTRKQRRPVACFASEEHGMSFTTLVAKGNFIYTGTTMGALKAFDTRRMKTHVHTYKGFTGGISDLHLDATGRFLSSASLDRYVRIHDSETTVLLYQCYVKSKATKILIRPFENEARVTEEPEEVADLQMDRNVSENKSVNATSVDNEYEDMFDQMPTVGDSDNESEEEMSNIKLSKADLKRRSSEKSLKNKKKKVVIS
Protein: POP4 homolog, ribonuclease P/MRP subunit (K7EQV2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGPGYLLLRSPNRTATGMGPPYLRKTEGWSTGVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPDT
Protein: Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) (O15143)
Organism: Homo sapiens (Human)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:29925947}.
Interaction partners:
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5
- Actin nucleation-promoting factor WASL
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin nucleation-promoting factor WAS
- Actin-related protein 2/3 complex subunit 1A
Sequence:
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
Protein: Beta-nerve growth factor (Beta-NGF) (P25427)
Organism: Rattus norvegicus (Rat)
Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01138}. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000250|UniProtKB:P01139}.
Interaction partners:
- BDNF/NT-3 growth factors receptor
- High affinity nerve growth factor receptor
- NT-3 growth factor receptor
- Tumor necrosis factor receptor superfamily member 16
- VPS10 domain-containing receptor SorCS2
- Sortilin
- GDNF family receptor alpha-1
- Glial cell line-derived neurotrophic factor
- Neuromodulin
- Neurotrophic factor BDNF precursor form
Sequence:
MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPAEPIAARVTGQTRNITVDPKLFKKRRLRSPRVLFSTQPPPTSSDTLDLDFQAHGTISFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLGEVNINNSVFKQYFFETKCRAPNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDDKQAAWRFIRIDTACVCVLSRKAARRG