wanglab/gogpt-training-data huggingface dataset:
Protein: Trafficking protein particle complex subunit 11 (Q7Z392)
Organism: Homo sapiens (Human)
Function: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:27862579}. Golgi apparatus, cis-Golgi network {ECO:0000250}.
Interaction partners:
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit 12
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 13
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 3
- Trafficking protein particle complex subunit 4
Sequence:
MSPTQWDFPVELCCRPMAFVTLTGLDVVYNAVHRAVWDAFCANRRADRVPISFKVLPGDHEYPKCRPKRTSYEWYIPKGILKTGWMNKHLNLVPALVVVFYELDWDEPQWKEKQSECATRVEIVRQSLQGRNTKVAVVLIQKKTPLPPGEDVIASERAAALCNACELSGKSLFVLPHTDHLVGYIIRLENAFYEHAQTYYYTEIRRVKSHKEFLNKTTHQLLFVRHQFKIAFFSELKQDTQNALKNYRTAYNLVHELRAHETNILEIKTMAGFINYKICRLCFQHNTPLDAIAQFRKHIDLCKKKIGSAELSFEHDAWMSKQFQAFGDLFDEAIKLGLTAIQTQNPGFYYQQAAYYAQERKQLAKTLCNHEASVMYPNPDPLETQTGVLDFYGQRSWRQGILSFDLSDPEKEKVGILAIQLKERNVVHSEIIITLLSNAVAQFKKYKCPRMKSHLMVQMGEEYYYAKDYTKALKLLDYVMCDYRSEGWWTLLTSVLTTALKCSYLMAQLKDYITYSLELLGRASTLKDDQKSRIEKNLINVLMNESPDPEPDCDILAVKTAQKLWADRISLAGSNIFTIGVQDFVPFVQCKAKFHAPSFHVDVPVQFDIYLKADCPHPIRFSKLCVSFNNQEYNQFCVIEEASKANEVLENLTQGKMCLVPGKTRKLLFKFVAKTEDVGKKIEITSVDLALGNETGRCVVLNWQGGGGDAASSQEALQAARSFKRRPKLPDNEVHWDSIIIQASTMIISRVPNISVHLLHEPPALTNEMYCLVVTVQSHEKTQIRDVKLTAGLKPGQDANLTQKTHVTLHGTELCDESYPALLTDIPVGDLHPGEQLEKMLYVRCGTVGSRMFLVYVSYLINTTVEEKEIVCKCHKDETVTIETVFPFDVAVKFVSTKFEHLERVYADIPFLLMTDLLSASPWALTIVSSELQLAPSMTTVDQLESQVDNVILQTGESASECFCLQCPSLGNIEGGVATGHYIISWKRTSAMENIPIITTVITLPHVIVENIPLHVNADLPSFGRVRESLPVKYHLQNKTDLVQDVEISVEPSDAFMFSGLKQIRLRILPGTEQEMLYNFYPLMAGYQQLPSLNINLLRFPNFTNQLLRRFIPTSIFVKPQGRLMDDTSIAAA
Protein: Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] (Q7Z3S7)
Organism: Homo sapiens (Human)
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent L-type calcium channel subunit beta-4
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent calcium channel gamma-4 subunit
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Sequence:
MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLLGTSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNFVELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEYLHVLSRPMVINHDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQAESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDPDLECDEELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISAFLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR
Protein: Malic enzyme (A0A1W2PPH1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
Protein: Testis-expressed protein 19 (Q8NA77)
Organism: Homo sapiens (Human)
Function: Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99MV2}. Note=Was initially reported to localize in the nucleus. However, it was later shown to localize in cytoplasm only. Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV2}.
Interaction partners:
Sequence:
MCPPVSMRYEEEGMSYLYASWMYQLQHGDQLSICFTCFKAAFLDFKDLLESEDWEEDNWDPELMEHTEAESEQEGSSGMELSWGQSPGQPVQGGSEAWGPGTLAAAPEGLEDAGLDPHFVPTELWPQEAVPLGLGLEDADWTQGLPWRFEELLTCSHWPSFFPS
Protein: Elongation factor 1 alpha-like factor (P91944)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAAQENTEISTKFSTLNVNAVEFVPSFSYNSVVNVAEEAAAVVVAAAAAEETADPGPASGSATPATTPDSVGSGGSTAGAAPPPPTAQGAGAAAPSAQPPTSSSNSASPAPGSPATTPSAGAAAADPTPIDGLNPSDKIANNETDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSKKKVVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTGMVHKRTLEKYEREAREKSRESWYLSWGLDTNQEERDKGKTVGVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLSGTGLKDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDMGTVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFVLCDAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE
Protein: Syndecan-4 (SYND4) (Ryudocan core protein) (P34901)
Organism: Rattus norvegicus (Rat)
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P31431}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000250|UniProtKB:P31431}.
Interaction partners:
- Fibroblast growth factor 2
- Fibronectin
- Syndecan-1
- Glypican-1
- Syndecan-2
- Paxillin
- Focal adhesion kinase 1
- Tenascin
- Thrombospondin-2
- Tudor-interacting repair regulator protein
Sequence:
MAPVCLFAPLLLLLLGGFPVAPGESIRETEVIDPQDLLEGRYFSGALPDDEDAGGLEQDSDFELSGSGDLDDTEEPRTFPEVISPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRVPSDVGDDDVSNKVSMSSTSQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
Protein: Novopsin-2 (Opsin 6, group member b) (X1WF41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Recoverin a
- Recoverin b
- Recoverin 3
- Recoverin
- ZPR1 zinc finger.
- ADP-ribosylation factor 4b
- Cone transducin alpha subunit, alpha transducing activity polypeptide 2) subunit alpha-2)
- Intraflagellar transport protein 20 homolog
- Rhodopsin kinase grk7a
- Rhodopsin kinase grk7-b
Sequence:
MDIHSIPPTNITVYRVSDGGETAIGVYLVILGWLSWIGNGTVILLLTKQRKALEPQDFLTLNLAISDASISIFGYSRGILEVFDVFRDEGYLIKTFWTCKVDGFLILLFGLISINTLTAISVIRYIKGCHPHHAHHINKRNICLVITAVWLFCLFWAGAPLLGWGSYRARGYGTCEIDWTRALYSIPFKLYVIGIFFFNFFVPLFIIVFAYVSIIRTVNSSHKSSQGGDVSERQKKIERSITRVSLILCAAFLLAWSPYAVISMWSALGYQIPTLNGILASLFAKSASFYNPFIYIGMSSKFRKDLQALFYCLRPTSAHRPTPPAPLAQPADVQLNVEDEPVEMDHNLSEHIHEEKAETPSEVECQNSPLIEPHNISPHGLMRKPSNSGRL
Protein: Transcriptional anti-antiactivator ExsC (P26995)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Part of the regulatory cascade that plays a role in the transcriptional regulation of the type III secretion system (T3SS). Interacts with antiactivator ExsD to inhibit its activity leading to ExsA-mediated transcription.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15225323}.
Interaction partners:
- Type III secretion regulatory protein ExsE
- Transcriptional antiactivator ExsD
- Type 3 secretion system pilotin
- HTH-type transcriptional regulator ExsA
- Translocator protein PopB
- Type III secretion protein PcrV
- Regulatory protein PcrH
- Secreted exoenzyme S
- Translocator outer membrane protein PopD
- Exoenzyme T
Sequence:
MDLTSKVNRLLAEFAGRIGLPSLSLDEEGMASLLFDEQVGVTLLLLAERERLLLEADVAGIDVLGEGIFRQLASFNRHWHRFDLHFGFDELTGKVQLYAQILAAQLTLECFEATLANLLDHAEFWQRLLPCDSDREAVAAVGMRV
Protein: GATA zinc finger domain containing 2B (A0A0U1RRM1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNRTAGRPGKENINDEPVDMSARRSEPERGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGIEERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSKLPSRPGAQGVEPQNLRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQRGPPKPGLQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSSPLPSPSAMTDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMVGLEEVVQSVIDSQGKSCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQKKALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTLRQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKGPSLADRQREYLLDMIPPRSISQSISGQK
Protein: Pfmc-2TM Maurer's cleft two transmembrane protein (O96287)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MFHYIYKIYIFTIILCASNLFNNNVVEIGTYKLSYHNGGIQFRMLAQKNTNKKPFGNTLTNILFKDKKKKNLDPQISSLVSLVDNMDITQEKKDKIKNLSLKYINSRDVKEKNESINELQKYSNNEECKEYMDSYLMHLRMQNDIKCLKRKNLWNNIWIVSTTLLLIIIMIACIIVCTPETYTALYPAFILLIFIIHIVARYFPDMKIGFKKLKTKLNTFFQNKKQITK
Protein: Uncharacterized protein (Q3UVE0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLGSSHTVGWVRPETGQTEQHRLQFRFNLVNLAYLTNMVSVAHLVVLVPIVPDMSAVLLVLCPFRIHHFLFPPHISPSLAQDLLWDQICKLIALFILGPRQLPFCI
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (M0R3J4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
- Bone morphogenetic protein 4
- Growth/differentiation factor 5
- Bone morphogenetic protein 7
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein 2
- Bone morphogenetic protein 6
- Activin receptor type-1
- Growth/differentiation factor 6
- Bone morphogenetic protein 15
- Mothers against decapentaplegic homolog 5
Sequence:
MWAPRRRMVRVQPPLLGPRSCVVNATTTVLKTQSTISADGYCFTMIEEDDSGTPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRTHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
Protein: Protein-lysine N-methyltransferase efm4 (EC 2.1.1.-) (Elongation factor methyltransferase 4) (Secretion and early endocytosis protein 1 homolog) (Q9P7Z3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein N-terminal and lysine N-methyltransferase efm7
- UPF0665 family protein C23C4.06c
- Protein-lysine N-methyltransferase rrg1
- Protein-lysine N-methyltransferase efm3
- Alpha N-terminal protein methyltransferase 1
- Eukaryotic translation initiation factor 6
- Probable MRF1 mitochondrial N
- tRNA wybutosine-synthesizing protein 2
Sequence:
MSGLPESKLGTKQYWDNVYEREVSNFTEFNDEGEVWFGEEAEERIVQWLEDHISTSFREVSEAAPFRVLDLGTGNGHLLFRLLEEEDTLLPSPCQLVGVDYSEAAIVLAKNIARHRQFSDKVKFQQLDIIKDSKFCSKDWDLILDKGTFDAISLSGELLDGRPLNSVYVDRVRGMLSPNGIFLITSCNWTIQELEERFTKNGFIVHSTVPVPVFEFQGSTGSSTSVIAFQIDPSFNRK
Protein: Exosome complex exonuclease RRP44, putative (Q384J0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosomal RNA processing protein 45
- Exosome component CSL4
- Telomerase-associated protein, putative
- RNasePH-like protein exosome-associated protein 1 Rrp42 homologue
- Ribosomal RNA-processing protein 43
- Exosome complex exonuclease RRP40
- Ribosomal RNA processing protein 4
- Elongation factor 1-alpha, putative
- Exosome complex exonuclease RRP41A
- Exosome-associated protein 4
Sequence:
MDETPNAVKQLYTDVEYTIGSNPEMEKQVKHGCVVIGRLRVYSSYNSGLAFVRSGAFPADVVVKGYGSINRFLHNDVVAVQLLPMEQWEDVVSGELEPDGDDKDEFRTMRPDSERLPDGRRITRWIRDTTMNNRKNREMWLAEMMSAPTQHNWHGKKPSGSVIAVLERKHPLLFVARLADDALSSQEVIQDRRFYRFKVFDQLLPHIAVFGRDIPFSLRESIRERFYLLRLETTTGGDIVWVESRFPTARIISTFGSVHSLRANTFAICSAHHIVTDDFSEEACNCIPDRLIIPNSEEMKRTGRRDLRREEFVCSIDPATARDLDDALSITLLPGGYRVGVHIADVSHFVSPGSALDEEGRARATSVYLVDRVYHMLPRKLSEEYCSLHPGSDKLAFSAIFQLDLNGKLKGEWFGKSVIRNRCRLSYDDAQRIIDGNLTTLDALDYGGVTDRRELSQLKERVATSVKHLFDLASKLRAASFERGRLAFSTPEIGFHFEDISNPTHPIGFNVHRQIEANWLVEEFMLLANLRVAQKIVQYLPDQAILRVHPPPKRVLFEQLKLSLARVNIELKGRSNKSLEQLLNSVRDHPLRDEISIMVKNTLSLAKYCTNGENFTNKVPLGHYALGLEWYTHFTSPIRRYADIIVHRQLLCALEIESIVKGKHRTGKTCAGAVGMEVECLDSAEFFTSTYEVMNIADECNENKRAADSVSEASLKLFFCHYLKSLRSLWVSSNKEDPFIPRVDAVVISVAPEKKVLMLYARVVGISVEISLKSKTQKFVAESGNNENRDESNKEETASLHSEIRRKRGSATGGNHRGGERQKSPPRAQEAKITINWGLHPQTNEKVEEEIKELMMVSAVLTIKRNVKGYEEPDMIMDPPWLRDEKRMAIPTSLV
Protein: Serine/arginine-rich splicing factor RS2Z33 (RS-containing zinc finger protein 33) (At-RS2Z33) (At-RSZ33) (AtRSZ33) (Q8VYA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Splicing factor involved in constitutive and/or alternative splicing. Regulates the splicing of its own pre-mRNA and the alternative splicing of RS30, RS31 and RS34. Associates the cyclin-dependent kinase G1 (CDKG1) with the spliceosome and recruits it to U1 snRNP to facilitate splicing.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:12176998, ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:15686520, ECO:0000269|PubMed:18674533}.
Interaction partners:
- Serine/arginine-rich SC35-like splicing factor SCL30
- Serine/arginine-rich splicing factor SC35
- U1 small nuclear ribonucleoprotein 70 kDa
- Serine/arginine-rich splicing factor RSZ21
- Serine/arginine-rich-splicing factor SR34
- Serine/arginine-rich SC35-like splicing factor SCL28
- Serine/arginine-rich SC35-like splicing factor SCL30A
- Serine/arginine-rich splicing factor RSZ22
- RNA-binding
- RNA-binding protein Y14
Sequence:
MPRYDDRYGNTRLYVGRLSSRTRTRDLERLFSRYGRVRDVDMKRDYAFVEFGDPRDADDARHYLDGRDFDGSRITVEFSRGAPRGSRDFDSRGPPPGAGRCFNCGVDGHWARDCTAGDWKNKCYRCGERGHIERNCKNSPKKLRRSGSYSRSPVRSRSPRRRRSPSRSLSRSRSYSRSRSPVRRRERSVEERSRSPKRMDDSLSPRARDRSPVLDDEGSPKIIDGSPPPSPKLQKEVGSDRDGGSPQDNGRNSVVSPVVGAGGDSSKEDRSPVDDDYEPNRTSPRGSESP
Protein: Precursor RNA processing 3, isoform B (RE44079p) (Q8MRG6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMAHAQREIEERKRALSNLRDKDPLLASVPSIGMPVALATQALAKKPTPEDSEKARKIAELQAQIRAKLTGNLASLIQPTAVAAAAAAAAQAQERPKPLILDDEGRTVDKSGRTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLRFHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPDDVPAMEWWDSVILTQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRRQNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDANNARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDCCVVVVEGGPKQQKKYRRLMLTRIKWEEDNAKGNDGQDVPNSCVLVWEGTSQRRHFGEIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTDQQ
Protein: Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) (O08522)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:8636227}; Single-pass type IV membrane protein {ECO:0000269|PubMed:8636227}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MAAGTSNYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSARDGGRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
Protein: Probable small intestine urate exporter (Solute carrier family 17 member 4) (Q9Y2C5)
Organism: Homo sapiens (Human)
Function: Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000255}. Note=Apical in the intestinal brush border. {ECO:0000269|PubMed:22460716}.
Interaction partners:
- Sodium-dependent phosphate transport protein 2A
Sequence:
MSTGPDVKATVGDISSDGNLNVAQEECSRKGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTHL
Protein: Uncharacterized protein ycf72 (ORF137) (Q36996)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein eS19
- 40S ribosomal protein S29, putative, expressed
- Small ribosomal subunit protein uS9
- Os10g0411700 protein
- 40S ribosomal protein S30
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS19
- 40S ribosomal protein S15, putative, expressed
- 40S ribosomal protein S6
- 40S ribosomal protein S6
Sequence:
MGAFPSPPPWGWSTGFITTPLTTGRLPSQHLDPALPKLFWFTPTLPTCPTVAKQFWDTKRTSPDGNLKVADLPSFAISFATAPAALANCPPLPRVISMLCMAVPKGISVEVDSSFLSKNPFPNCTSFFQSIRLSRCI
Protein: Tuftelin (Q9NNX1)
Organism: Homo sapiens (Human)
Function: Involved in the mineralization and structural organization of enamel.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P27628}. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites. {ECO:0000250|UniProtKB:P27628}.
Interaction partners:
- Ameloblastin
- Tuftelin-interacting protein 11
- Enamelin
- Amelogenin, X isoform
- Rab GTPase-activating protein 1
- Dentin sialophosphoprotein
- Zyxin
Sequence:
MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQARAKTENPGSIRISKPPSPKPMPVIRVVET
Protein: 2',5'-oligoisoadenylate synthetase-dependent ribonuclease L (Q80WM6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
METTDHSTPQCGSASAGGQKTVGKDDYLLIEAVNKGDADRVQQLLEQGADANVCEESGGWTPLHNAVQSGRVDIVNLLLRYGADPHRRKKNGATPFIVAGICGDVSLLQIFLSRGANINERDMYGFTAFMEAAEYGNVEALKFLFAEGADVNLRRETTEDRRRLKQGGATALMSAAENGHPEVVRILLDEMKAEADARDNMGRNALIRSLLNRDCENVEIHVEEITSVLIQYGADINVRGEGEKTPLISAVKRKHTGLVQMLLSQEGIKVNDRDSEGKTALQIAVELKLKEIVRLLLEKGADTKCGDLVWIAKRNYDHGLVKLLLSYEANHDTNPPAKDWLPHSARWGEALERLHSVSRPMTGKLKIFMNDDYKIASTSEGGIYLGIYDNREVAVKVFCENSSRGRKEVSCLRDCGDHSNLLTFYGSEEHKGSLYVCVSLCESTLEKFLNVPREEPMEKGEDKFALSVLLSIFKGVQKLHMHGYSHQNLQPPNILIDSEKAVRLADFDESIQWMRESQTVQRDLEDLGRLVLYVVNKGEIPFETLKGQNDEELLTIAPNEETKDLVHCLFSPGENVKNCLMDLLGHPFFWTWENRYRTLRDVGNESDIKVRNNKSKLLKLLQPQTHAPSRSFDRWTSKIDKRVMSDMNGFYKSRKGYRDTVGDLLKFIRNIGEHINEEKNRQMKEILGDPSRYFQETFPDLVIYIYKKLKETEFRKHFPQPPPSLSVPEAAGPGGVQS
Protein: Transcription factor Sox-8 (Q6VVD7)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox9 and sox10 to induce neural crest progenitors. Regulates the onset of expression of many neural crest marker genes including sox10, and regulates the development of multiple neural crest derivatives. May be required to regulate neural crest cell migration.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
Sequence:
MLNMSSDQEPPCSPTGTASSMSHVSDSDSDSPLSPAGSEGRGSHRPPGISKRDGEEPMDERFPACIRDAVSQVLKGYDWSLVPMPVRGSGGLKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSENEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKAGQSDSDSGAELGHHPGSQMYKSDSGMGSMGENHLHSEHAGQNHGPPTPPTTPKTDLHHGGKQELKHEGRRMMDNGRQNIDFSNVDINELSSEVISNIEAFDVHEFDQYLPLNGHGAIPADHGQNTTAAPYGPSYPHAAGATPAPVWSHKSSSTSSSSSIESGQQRPHIKTEQLSPSHYNDQSQGSPTHSDYNTYSAQACATTVSSATVPTAFPSSQCDYTDLPSSNYYNPYSGYPSSLYQYPYFHSSRRPYATPILNSLSIPPSHSPTSNWDQPVYTTLTRP
Protein: Jetlag, isoform B (Q0E8T8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCTLHPEEEAHLMAMASGGQPTRTASPRPLVTASIAAPRSLFDVCWDDVLIPQVAVYLSLKDLFNLRCCSRTAQRFVEAALEKRQELHLSGNNTKNIDVAFRVLARCCQRLEVLHLACCRWLTDELLLPLLANNKKRLWAVNLNECVNITALSLQPIIVECKELRVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNKLTVLSLANTPSVTDQVLIQIGNYCRELEHINVIGCAAISDYGVHALTSSCPLLQSLMVQRCPLVTERVLAPLRGRVHIDRPGMGYMPTVQHHRLFLQV