wanglab/gogpt-training-data huggingface dataset:
Protein: Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] (O08912)
Organism: Mus musculus (Mouse)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity).
Subcellular location: [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted {ECO:0000250}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
Sequence:
MRKFAYCKVVLATSLVWVLLDMFLLLYFSECNKCEEKQERGLPAGDVLELVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSRGQVITFLDAHCECTAGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRRKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTLPEIF
Protein: ATP synthase subunit O, mitochondrial, putative (EC 3.6.3.14) (Q8IEL5)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- ATP synthase subunit gamma
- ATP synthase subunit beta
- ATP synthase subunit C, putative
- ATP synthase subunit epsilon, mitochondrial, putative
- ATP synthase subunit alpha
- ATP synthase subunit delta, mitochondrial, putative
- JmjC domain-containing protein, putative
- V-type proton ATPase 21 kDa proteolipid subunit, putative
- V-type proton ATPase proteolipid subunit
- Cytochrome c1, putative
Sequence:
MRYAFGTSYLTCFMGINKAMKKFVFKKNKYSSLHLFERNEINNFQINIMDRKYVHSIKEEKKKEESEDYYLSMGDNIEKRYSLALYNVAKKQNKINEISNDMLFIKNHLLKDTTFQKFLHTPNIEKKEKIHFIKNECKTLNKFNIITENFIESLFDSKRISFLPKIIEEFEFLLLKQRKEIKCVVYTANEIDNNYKQKIQDSILIKLNKKLIPIIQYKTDPYILGGLILQIGNQVYDFSAKSKIDKIKTNFSQ
Protein: Uncharacterized protein orf152 (Uncharacterized protein orf152b) (Q2F989)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MSPKNTCPPHRLCVDSDTPIHCWIPASLRVSNDSNKSNQNPKPVLLLIPGFGVHAIWHWNAHFVPIALFLHNCPLSYIFFFSSLRGLSQTGCERDLCRPLFVNSENVGLRPFAARLFRRNTKPRVVRSKTMLSRYGPPTLPFQLVFSEQYDT
Protein: SUMO-activating enzyme subunit 1B-2 (SUMO-activating enzyme subunit 1-2) (Ubiquitin-like 1-activating enzyme E1A) (P0DI13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Functionally redundant with its paralog SAE1A (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SUMO-activating enzyme subunit 2
- SUMO-conjugating enzyme SCE1
- Translation machinery-associated protein 22
- Ubiquitin-fold modifier-conjugating enzyme 1
- Ubiquitin-like modifier-activating enzyme 5
- Autophagy-related protein 3
- Molybdopterin synthase catalytic subunit
- Probable NEDD8-conjugating enzyme Ubc12-like
- NEDD8-conjugating enzyme Ubc12
- Small ubiquitin-related modifier 3
Sequence:
MDGDELTEQETALYDRQIRVWGAGAQRRLSKSHVLVSGIKGTVAEFCKNIVLAGVGSVTLLDDRLVTTEVFNANFLILPDENAYVGKTVAEICCDSLKDFNPMVHVSIEKGDLSTLGVDFFEKFDVVVIGYSSRATKKAVNEKCRNLAKDVAFYTVDCRGSCGEIFVDLQNYKYTKKKLDETVECELTFPSFEEAVSVPWKPMPRRTAKLYFAMRVIELFEETEGRKPGECSLSDLPRVLKLKKELCEGNSVSENHIPDILLERLVSNNTEFPPACAIIGGILGQEVIKVISGKGEPLKNFFYFDAEDGKGVIEDLSHKL
Protein: Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) (O76094)
Organism: Homo sapiens (Human)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68. Can bind 7SL RNA with low affinity. The SRP complex possibly participates in the elongation arrest function (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22541560}. Endoplasmic reticulum {ECO:0000269|PubMed:22541560, ECO:0000269|PubMed:28369529}.
Interaction partners:
- Signal recognition particle subunit SRP54
- Signal recognition particle 19 kDa protein
- Signal recognition particle subunit SRP68
- Signal recognition particle 14 kDa protein
- Signal recognition particle 9 kDa protein
- Signal recognition particle receptor subunit alpha
- Signal recognition particle receptor subunit beta
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL18
Sequence:
MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW
Protein: StAR-related lipid transfer domain containing 7 (D3ZXY9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGRGEDPGGGVAELDTEYRKKWDALVIKLEVIERDAVSGSEVLHWVTHFPYPMYSRDYVYVRRYSVDQENNVMVLVSRAVEHPSVPESPEFVRVRSYESQMVIRPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHTATLKAKNMEIKVKDYISAKPLEMSSEAKATASSPERKNEGSCGPARIEYA
Protein: Probable protein phosphatase 2C 40 (AtPP2C40) (EC 3.1.3.16) (Protein phosphatase 2C homolog 1) (Q9LUS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g35730
- ER membrane protein, putative
- At5g47730
- Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3
- Fimbrin-2
- Classical arabinogalactan protein 7
- Dirigent protein 7
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
- Phosphatidylinositol-3-phosphatase myotubularin-2
Sequence:
MQEGTDPYGEIEISFGYQCNNKKIGIPEDKIADGREVLGGFRLQKTSSFSCLSGAALSGNPTLANTNICNGVIGSEILPSLDSPKSFRKVPSSPALSKLDILSPSLHGSMVSLSCSSSTSPSPPEPESCYLTSMSSPSSVNEGFLLSAMEVQVAGGAAGEDRVQAVCSEENGWLFCAIYDGFNGRDAADFLACTLYESIVFHLQLLDRQMKQTKSDDDGEKLELLSNISNVDYSSTDLFRQGVLDCLNRALFQAETDFLRMVEQEMEERPDLVSVGSCVLVTLLVGKDLYVLNLGDSRAVLATYNGNKKLQAVQLTEDHTVDNEVEEARLLSEHLDDPKIVIGGKIKGKLKVTRALGVGYLKKEKLNDALMGILRVRNLLSPPYVSVEPSMRVHKITESDHFVIVASDGLFDFFSNEEAIGLVHSFVSSNPSGDPAKFLLERLVAKAAARAGFTLEELTNVPAGRRRRYHDDVTIMVITLGTDQRTSKASTFV
Protein: Vesicle-trafficking protein SEC22c (SEC22 vesicle-trafficking protein homolog C) (SEC22 vesicle-trafficking protein-like 3) (Q9BRL7)
Organism: Homo sapiens (Human)
Function: May be involved in vesicle transport between the ER and the Golgi complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9501016}; Multi-pass membrane protein {ECO:0000269|PubMed:9501016}.
Interaction partners:
- BET1 homolog
- Golgi SNAP receptor complex member 2
- Syntaxin-5
- Synaptobrevin homolog YKT6
- Golgi SNAP receptor complex member 1
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Sec1 family domain-containing protein 1
- Protein transport protein Sec23A
- Protein transport protein Sec24B
Sequence:
MSVIFFACVVRVRDGLPLSASTDFYHTQDFLEWRRRLKSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTCIGLASRPYAFLEFDSIIQKVKWHFNYVSSSQMECSLEKIQEELKLQPPAVLTLEDTDVANGVMNGHTPMHLEPAPNFRMEPVTALGILSLILNIMCAALNLIRGVHLAEHSLQVAHEEIGNILAFLVPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQILFHIGVAFLSSYQILTRQLQEKQSDCGV
Protein: Importin subunit alpha-1 (IMPa-1) (Karyopherin subunit alpha-1) (KAP-alpha-1) (Q96321)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to conventional NLS motifs with high affinity in the absence of an importin beta subunit. Mediates nuclear protein import across the nuclear envelope in vitro in the absence of exogenously added importin beta subunit. Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:8776900}.
Interaction partners:
- Importin subunit beta-1
- Transcription factor VIP1
- Nuclear cap-binding protein subunit 1
- Exportin-2
- Protein TPX2
- Transportin
- F-box protein VBF
- Ran-binding protein 1 homolog a
- Nucleoporin
- Plant-specific TFIIB-related protein 1
Sequence:
MSLRPNAKTEVRRNRYKVAVDAEEGRRRREDNMVEIRKSKREESLMKKRREGMQALQGFPSASAASVDKKLDSLKDMVAGVWSDDPALQLESTTQFRKLLSIERSPPIEEVISAGVVPRFVEFLKKEDYPAIQFEAAWALTNIASGTSDHTKVVIDHNAVPIFVQLLASPSDDVREQAVWALGNVAGDSPRCRDLVLGCGALLPLLNQLNEHAKLSMLRNATWTLSNFCRGKPQPHFDQVKPALPALERLIHSDDEEVLTDACWALSYLSDGTNDKIQTVIQAGVVPKLVELLLHHSPSVLIPALRTVGNIVTGDDIQTQCVINSGALPCLANLLTQNHKKSIKKEACWTISNITAGNKDQIQTVVEANLISPLVSLLQNAEFDIKKEAAWAISNATSGGSHDQIKYLVEQGCIKPLCDLLVCPDPRIITVCLEGLENILKVGEAEKNLGHTGDMNYYAQLIDDAEGLEKIENLQSHDNNEIYEKAVKILETYWLEEEDDETQQPPGVDGSQAGFQFGGNQAPVPSGGFNFS
Protein: AMP deaminase (EC 3.5.4.6) (Q76NR0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNFNRMDTAHRLRVDVRLYGGSMGNQLNDKGTASSTPTISSDDLSDLADSPVDEKAEADVEVTNEISAPYEVPQFPIEQIEKKLQIQRHLNEKQATGPRPVATAAVLATNRESSSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLKTVKLKDRINNLPVKEVSDVHLRHSPMKITNPWNVEFPNDEDFKIKPLNGVFHIYENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDELSNIFKVNQTCSIADMNAT
Protein: Cold shock domain containing E1 (E9PLT0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID
Protein: Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT 1) (TAT 1) (EC 2.3.1.108) (Mechanosensory abnormality protein 17) (O45100)
Organism: Caenorhabditis elegans
Function: Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.
Interaction partners:
- Tubulin alpha-3 chain
- Tubulin beta-1 chain
- Tubulin polyglutamylase ttll-4
- Tubulin polyglutamylase ttll-5
- Mechanosensory protein 3
- Histone deacetylase 6
- AMP-binding domain-containing protein
Sequence:
MQVDADLRPILGPQLVRLDPMRVKQLQDPIVYEAIDNLAKLSAHCLQLRTPLTTCEKLINSDSTLYLSWKYDEEEKVSRLMGFAKVGRKKLFLYDSQMQTYEGEILCLLDFYVHFSCQRQGVGQQILDYMFSQEHTEPYQLALDNPSVTLLGFMSQKYGLIKPVWQNTNFVVFEELFLALSAENGIEKPPPDGWRRPMTPRRLGTGMTDTRWLQHAVSGHQSKGNAMAAPVDADMTPQGALSNRAHQAKARKAHILSSKPLW
Protein: Photosynthetic NDH subunit of lumenal location 2, chloroplastic (PsbQ-like protein 1) (Q9XI73)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable). Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:20460499}; Peripheral membrane protein {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:20460499}; Lumenal side {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:20460499}. Note=Associated with the chloroplast NAD(P)H dehydrogenase/photosystem I (NDH/PSI) supercomplex.
Interaction partners:
- Photosynthetic NDH subunit of lumenal location 1, chloroplastic
- Photosynthetic NDH subunit of lumenal location 4, chloroplastic
- Photosynthetic NDH subunit of lumenal location 3, chloroplastic
- NAD
- Photosynthetic NDH subunit of subcomplex B 5, chloroplastic
- NAD
- Photosystem I chlorophyll a/b-binding protein 6, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 4, chloroplastic
- NAD
- Photosynthetic NDH subunit of subcomplex B 1, chloroplastic
Sequence:
MSSFTTTNTPPPYLLRKIYHRRVNQPFSVVCCTGEPQQDIFTRRRTLTSLITFTVIGGATSSALAQEKWGTRSFIKEKYFMPGLSPEDAAARIKQTAEGLRDMREMLDHMSWRYVIFYIRLKQAYLSQDLTNAMNILPESRRNDYVQAANELVENMSELDFYVRTPKVYESYLYYEKTLKSIDNVVEFLA
Protein: Proton-activated chloride channel (PAC) (Transmembrane protein 206) (Q9D771)
Organism: Mus musculus (Mouse)
Function: Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H813}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
Interaction partners:
Sequence:
MIRQELSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIAFYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPFFNHTMQSALIVQGPQEVKKRELVFLQFRLNQSNEDFSAIDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAERSAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRYLKRRGQATNHIS
Protein: Spermatogenesis-associated protein 6 (Q9NWH7)
Organism: Homo sapiens (Human)
Function: Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q3U6K5}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q3U6K5}. Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece. {ECO:0000250|UniProtKB:Q3U6K5}.
Interaction partners:
- SUN domain-containing protein 5
- DNA repair protein SWI5 homolog
- Outer dense fiber protein 1
Sequence:
MPKVKALQCALALEISSVTCPGVVLKDKEDIYLSICVFGQYKKTQCVPATFPLVFNARMVFEKVFPDAVDPGDVVTQLEYDTAVFELIQLVPPVGETLSTYDENTRDFMFPGPNQMSGHHDSNRQVTMRRISGLRGNAPRLEFSTTSVITECLISSRKCHTQDKFIYHLAPVEKSHGRLQNRTSRSQKKKSKSPERSKYCINAKNYEQPTISSKSHSPSPYTKRRMCELSEDTRRRLAHLNLGPYEFKKETDKPPFVIRHVDPPSPRADTLLGSSGRDCERDGWSRVHNDHSHLGCCRPKDYKVIRTPHGRDFDDSLEKCEEYLSPRSCSKPRHSARTLLVHSAPSTMPKHSPSPVLNRASLRERFHSDWCSPSNCDEIHDRVKNVLKSHQAHQRHLYDERDLEKDDELELKRSLLCRDSAYDSDPEYSSCQQPRGTFHLDDGEYWSNRAASYKGKSHRPIFENSMDKMYRNLYKKACSSASHTQESF
Protein: Zinc finger A20 and AN1 domain-containing stress-associated protein 5 (AtSAP5) (Q9LHJ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in environmental stress response.
Interaction partners:
- Zinc finger AN1 and C2H2 domain-containing stress-associated protein 13
- Zinc finger AN1 domain-containing stress-associated protein 12
- At2g14045
- E3 ubiquitin-protein ligase SDIR1
- F6A14.21 protein
- E3 ubiquitin protein ligase DRIP2
- Heat shock protein 90-5, chloroplastic
Sequence:
MAQRTEKEETEFKVLETLTTTTTTLCTNNCGVTANPATNNMCQKCFNASLVSAAAGVVESGSILKRSARSVNLRSSPAKVVIRPREIDAVKKRDQQIVNRCSGCRKKVGLTGFRCRCGELFCSEHRYSDRHDCSYDYKTAGREAIARENPVVKAAKMVKV
Protein: Tousled-like kinase, isoform L (EC 2.7.11.1) (M9PDQ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDQFQTSLNPRKLELLESRITGVRMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS
Protein: Zinc finger protein 384 (Cas-associated zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Q9EQJ4)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1.
Subcellular location: Nucleus {ECO:0000269|PubMed:10669742}.
Interaction partners:
Sequence:
MEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLSSGISMDTESKSEQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASSAQTFPISTPMIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGTVAPPKPPRGRKKKRMLESGLPEMNDPYVLAPGDDDDHQKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEAHLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKHNPPDLQQQVQAAAAAAAVAQAQAQAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQPPPPQPPHFQSPGAAPQGGGGGDSNQNPPPQCSFDLTPYKPAEHHKDICLTVTTSTIQVEHLASS
Protein: Glycogen synthase kinase 3 (GSK-3 short) (EC 2.7.11.26) (Q388M1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- uracil phosphoribosyltransferase
- Uncharacterized protein
- BRCT domain-containing protein
- Casein kinase II subunit beta
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Calmodulin, putative
- Calmodulin, putative
- Uncharacterized protein
- Calmodulin-like protein, putative
Sequence:
MSLNLTDAADDRSYKEMEKYTVERVAGQGTFGTVQLARDKSTGSLVAIKKVIQDPRFKNRELQIMQHLARLRHPNIVMLKNYFYTVGGEGRRNDVYLNVVMEFVPETLHRTCRNYYRRMTNPPLILVKVFMFQLLRSIACLHIPVINICHRDIKPHNVLVDEQTGELKLCDFGSAKRLAADEPNVAYICSRYYRAPELIFGNQFYTTAVDIWSVGCIFAEMLLGEPIFCGENTSGQLREIVKILGKPTKEELHKLNGSSTEINANAKATPWENVFKQPLPAEVYDLCGKIFKYVPDQRITPLDALCHPFFNELREPTTKLPSGNPLPAHLYQFTPDEVEAMTEAQREYLLKK
Protein: Ninein (GSK3B-interacting protein) (Ninein isoform X3) (F1QE08)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MDGARDQYEERLKEVFESFDGSGLGSLSPEELSDLCQALQLEENTLNTLLHTLLDDHITARVDFEQFKDALILVLSSTNTNDEEECLEQPDSPEVQPRFVKGSKRYGRRSAPEFIPTHTDSNIQADDEEEKDEDAQESDDRTVPRKRERWNADMSISEEFEAEGQLHLWNPDEPTTPRGKALSLCDLEERLQNACLQLSLPVNGMATLSQLHALCQHIGIEVGEDLLQCADESLMDVQEFISCVINHSKPPTPSASTPYRQLKRIHSTQFDESGRRISCALSSTIALRVFSDLDDGSGHAPVETLLNRWMEEGVDNSSEILQALDFNLEGKVNLSELTVALENELLSTKNSIHQAALLSFKAEIRHLLECVDLERREKERIRFDLDTAEKLKSELASEVDDHHAAIERNNELNLRRVEQEYKESMTALRTELSKEMELVQQQANQQREELEQEISKMRDDETFLREHLTLTIKENGRLESELIETTEKLVEAENQLNKVQKNLDGVLKEKFGDLDPDSAEFYQQEDRLRQLRRSYEEQCRELQDRIDELEAQLEEYQTSGHTPLRRPGLSLSDEMASKSLEPGFQEQQPLNMSLETEMLLEQHQREIENIRAMVDEEKRSAEEEKDLLSLNHQQELQVLRGEMERELERANKLEQEISVLQNLHQQELHSLTQEAQDAKTCAEQLQAKVQVLEEKQTAYEEQSNAHAEEMSLMELKHQEMLETSMQEQRERLEEEKEKRLTEQWKEQQKSYEEMLNAQLEEMQQRTEQECTELEKRLRDEWDQEKQELEESSREKLNSILEERERRLREEWEQERQELEEISKEALQAVLEERSERETRLRQQWDEERASMENKHHALLLQHLQEEREHFRTQQEETESIIFEHWARERAQLERQHKEALQACLEQERERLQVDREEQESRWQQVLIEEQSRVEEAHRGAMLELTAKHNEERERLSSLLEKLRTDIAEQRSEVCRLAKENFILRHKISTVREQDLRENQDDARLQHIKQGKRSVQALRRQLSEPRRLGQQLEEESFILQQNSDHVLRHALQEVIRQHDGSANGKNGLCDREEISSRTEKELLRSELNRCIEKIMSLDSSLQTVTQQNARLKSDLRITQQERDALKQEVMSLHKQLQSANEKLLEVSVVSAGHQQGRRVWAELSGLMEAEHHSLKEENQQLKRQMNELSSELQTSKEQIRHLEALSAKQRGIVKNADQEKSALKREMEALHSQLLSTRNKAQLAAILPSSPLHLAGEQRGSHNSDGPDFNIQEREAALLQMEERMREVEITLRNLKLLLQEKVSQLKEQLIRNSESDVLIKDLYVENAQLLKALEKTEQRQKVAEKKNFLLEEKISSLNKIVRDLGPSPLTPAPYHFTRS
Protein: Vascular endothelial growth factor A-A (VEGF-A-A) (O73682)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation.
Subcellular location: Secreted {ECO:0000269|PubMed:17698971}.
Interaction partners:
- Vascular endothelial growth factor receptor kdr-like
- Vascular endothelial growth factor receptor 2
- receptor protein-tyrosine kinase
- Vascular endothelial growth factor receptor 3
- Neuropilin-1a
- Vascular endothelial growth factor Ab
- Platelet-derived growth factor receptor, beta polypeptide
- Angiopoietin-1 receptor
- Epidermal growth factor receptor precursor.
- Platelet-derived growth factor receptor alpha
Sequence:
MNLVVYLIQLFLAALLHLSAVKAAHIPKEGGKSKNDVIPFMDVYKKSACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQRVSQHNFQLSFTEHTKCECRPKAEVKAKKENHCEPCSERRKRLYVQDPLTCKCSCKFTQMQCKSRQLELNERTCRCEKPR
Protein: At5g09570 (Cox19-like CHCH family protein) (Q9LXC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g54100
- AAA-ATPase At2g18193
- At2g41380
- Protein NRT1/ PTR FAMILY 1.3
- Similar to part of disease resistance protein domain-containing protein)
- CCT motif family protein
- Non-specific lipid transfer protein GPI-anchored 29
Sequence:
MPRGSSGGRSSYRPSRPAAARSPPPQSVNRAPPPATAQPSSGGSFLGNIGASITEGLAWGTGTAFGHRVVDSVMGPRTFKHETVVSQVPSAANTMTACDIHSKAFQDCVNHFGSDISKCQFYMDMLSECKKNSGSVVAA