Protein: Zonadhesin (O88799)
Organism: Mus musculus (Mouse)
Function: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head.
Interaction partners:
- Ubiquitin-like protein FUBI
- Disintegrin and metalloproteinase domain-containing protein 2
- Zona pellucida sperm-binding protein 3 receptor
- Hyaluronidase PH-20
Sequence:
MALPVWTLMLLVGAAWGQEQVPAWRPNSPDLGPMVHTSREDSILSKCDFEDNSRPFCDWSQMSADDGDWIRTTGPSLTGTSGPPGGYPNGEGYYLHMDPKTFPQGGVARLRSPDIWEQGPLCVHFAFHMFGLSWGAQLRLLLLRGRKHLRPYVLWKHVNTQSPSWMPTTVTVPADHDIPSWLMFEGMRGNTAYLDISLDGLSIQRGTCNQVCMSQMCTFDTLNDLCGWSWVPTATGAKWTQKKGPTGKQGVGPAEDFSNPGNGYYMLLDSTNARPGQKAVLLSPLSHSRGCMTLSFHYIMHGQGHEEGLFVYATFLGNIRKYTLFSGHPGPDWQAVSVNYTGQGQIQFMVVGMFGNIPEPAIAVDAISIAPCGESFPQCDFEDRVHPFCDWNQVYGDMGHWSWGSKSVPTLIAGSPREFPYGGEHYIFFDSVKLSQEGQSARLVSPPFCAPGGICVEFAYHMYGLGKGTTLKLLLGSPAGSSPIPLWNRVGSQSSGWMNSSVTIPKGYQQPMQLFIEATRGTSTAFVVALNFILISHGPCRVLLQTEIPSSPLLPPTGPSESTVPTLPMEQPTSPTKATTVTIEIPTTPTEEATIPTETTTVPTEVINVSPKETSIPPEVTIPTEVITVSPEEIISPTEVTPVPTDVTAAYVEATNASPEETSVPPEVTILTEVTTVSPEETTVPTEVPIVLIEATAFPTGETTLYTEVPTVPTEVTGVHTEVTNVSPEETSVPTEETISTEVTTVSPEETTVPTEVPIVLIEATASPTGEITLYTEVPTVPTEVTGVHTEVTNVSPEETSVPTEETISTEVTTVSPEETTLPTEVPTVSTEVTNVSPEETSVPPEETILTTLYTEVPTVPTEVTGVHTEVTNVSPEETSVPTEETISTEVTTVSPEETTLPTEVPTVSTEVTNVSPEETSVPPEETILTEITTVSPEETVFPIEGTTLPTEVLTVPIEVTTFPTGETTVPTEVPTVSTEMTGVHTEVTTVFPEETSIPTEVATVLPASIPPEETTTPTEVTTTPPEETTIPAEVTTVPPASIPPEETASLTEVTTTPPEETTTPTEVTTVPPEKTTIPTEVTTVPPASIFPEETTVPPEETTIASEETTVSTQETTLLTEQSAVTQTSIACRPPCPSPPLMPIGPLLSKPPGVSMFSLAPTTGVSTTESCPPNAHIELCACPASCESPKPSCQPPCIPGCVCNPGFLFSNNQCINESSCNCPYNNKHYKPGEEWFTPNCTERCRCLPGSLMECQISQCGTHTVCQLKSDQYQCEPYGKATCLVYGDLHFVTFDERHIGFTGTCTYILTQTCSNSTDHFFRITANTEERGVEGVSCLDKVVISLPETTVTMISGRHTLIGDQEVTLPAILSDDTYVGLSGRFVELRTTFGLRVRWDGDQQLFVTVSSTFSGKLCGFCGNYDGDSSNDNLKSDGMMTHDEEELRLSWQVEEDEDKDWVSSRCQKKKNPPSCDAALGSTMSGPKLCGQLVNPSGPFEACLLHLKASSFLDNCVTDMCSFQGLQQKLCARMSAMTATCQDAGYPVKPWREPQFCPLVCPKNSRYSLCAKPCPETCHPISTTQHCSDKCVEGCECDPGFILSGSECVPSSQCGCTSFQGRYFKLQEQWFNPDCKEICTCESHNHILCKPWKCKAQEACSYKNGVLGCHAQGAATCMVSGDPHYLTFDGALHHFMGTCTYVLTQPCWSKSQENNFVVSATNEIHDGNLEVSYVKAVHVQVFDLKISMFKGQKVVLNNQRVVLPVWPSQGRVTIRLSGIFVLLYTNFGLQVRYDGRHLVEVTVPSSYTGSLCGLCGNYNNNSMDDNLRADMKPAGNSLLLGAAWKILEASDPGCFLAGGKPSRCADSDMDDVWTKKCAILMNPLGPFSNCHEAVPPQASFSSCVYGQCETNGDNLTFCHSLQAYASLCAQAGQVTTWRNSTFCPMRCPPRSSYNPCANSCPATCLTLSTPRDCPTLPCVEGCECQSGHILSGTTCVPLRQCGCSDQDGSYHLLGESWYTEKTCTTLCTCSAHSNITCSPTACKANHVCLRQEGLLRCAAEMGECRISEDSQIVSFDDHSHPIQDTCTYILVKVCHPNTNMPFFMISAKTDINTNGKNKTFGVYQLYIDIFNFHITLQKDHLVLISLINDSIVTLPTTTHIPGVSVMTEDVYTIVTIKDEIQVKFESNNFLDVKIPASSNGKVCGVCGNFNGEEEDELMTPSGELAEDEQEFMNSWKDKSMDPNCQKIEGQNLQVEQQEIMNGKCRPIDFEKAQANCQTALQGPAWAHCSSRVPIKPFLLKCMNSFCEFRELFRALCDSLQSFEDACQNQGLKPPIWRNSSFCPLECPAHSHYTNCLPSCPPSCLDPDSRCEGSGHKVPATCREGCICQPDYVLLNDKCVLRSHCGCKDAQGVFIPAGKTWISEDCTQSCTCMKGSMRCWDFQCPPGTYCKNSNDGSSNCVKISLQCPAHSKFTDCLPPCHPSCSDPDGHCEGISTNAHSNCKEGCVCQPGYVLRNDKCVLRIECGCQHTQGGFIPAGKNWTSRGCSQSCDCMEGVIRCQNFQCPSGTYCQDIEDGTSNCANITLQCPAHSSFTNCLPPCQPSCSDPEGHCGGSTTKAPSACQEGCVCEPDYVVLNNKCVPRIECGCKDAQGVLIPADKIWINKGCTQTCACVTGTIHCRDFQCPSGTYCKDIKDDASNCTEIILQCPDHSLYTHCLPSCLLSCSDPDGLCRGTSPEAPSTCKEGCVCDPDYVLSNDKCVLRIECGCKDAQGVLIPAGKTWINRGCTQSCSCMGGAIQCQNFKCPSEAYCQDMEDGNSNCTSIPLQCPAHSHYTNCLPTCQPSCSDPDGHCEGSSTKAPSACKEGCVCEPDYVMLNNKCVPRIECGCKDTQGVLIPADKTWINRGCTQSCTCRGGAIQCQKYHCSSGTYCKDMEDDSSSCATITLQCPAHSHFTNCLPPCQPSCLDSEGHCEGSTTKAPSACQEGCVCEPDYVVLNNKCVPRIECGCKDAQGVLIPADKTWINRGCTQSCTCKGGAIQCQKFQCPSETYCKDIEDGNSNCTRISLQCPANSNFTSCLPSCQPSCSNTDVHCEGSSPNTLSSCREGCVCQSGYVLHNDKCILRNQCGCKDAQGALIPEGKTWITSGCTQSCNCTGGAIQCQNFQCPLKTYCKDLKDGSSNCTNIPLQCPAHSRYTNCLPSCPPLCLDPEGLCEGTSPKVPSTCREGCICQPGYLMHKNKCVLRIFCGCKNTQGAFISADKTWISRGCTQSCTCPAGAIHCRNFKCPSGTYCKNGDNGSSNCTEITLQCPTNSQFTDCLPSCVPSCSNRCEVTSPSVPSSCREGCLCNHGFVFSEDKCVPRTQCGCKDARGAIIPAGKTWTSKGCTQSCACVEGNIQCQNFQCPPETYCKDNSEGSSTCTKITLQCPAHTQYTSCLPSCLPSCLDPEGLCKDISPKVPSTCKEGCVCQSGYVLNSDKCVLRAECDCKDAQGALIPAGKTWTSPGCTQSCACMGGAVQCQSSQCPPGTYCKDNEDGNSNCAKITLQCPAHSLFTNCLPPCLPSCLDPDGLCKGASPKVPSTCKEGCICQSGYVLSNNKCLLRNRCGCKDAHGALIPEDKTWVSRGCTQSCVCTGGSIQCLSSQCPPGAYCKDNEDGSSNCARIPPQCPANSHYTDCFPPCPPSCSDPEGHCEASGPRVLSTCREGCLCNPGFVLDRDKCVPRVECGCKDAQGALIPSGKTWTSPGCTQSCACMGGVVQCQSSQCPPGTYCKDNEDGNSNCAKITLQCPTHSNYTDCLPFCLPSCLDPSALCGGTSPKGPSTCKEGCVCQPGYVLDKDKCILKIECGCRDTQGAVIPAGKTWLSTGCIQSCACVEGTIQCQNFQCPPGTYCNHNNNCAKIPLQCPAHSHFTSCLPSCPPSCANLDGSCEQTSPKVPSTCKEGCLCQPGYFLNNGKCVLQTHCDCKDAEGGLVPAGKTWTSKDCTQSCACTGGAVQCQNFQCPLGTYCKDSGDGSSNCTKIHKGAMGDGVLMAGGIRALQCPAHSHFTSCLPSCPPSCSNLDGSCVESNFKAPSVCKKGCICQPGYLLNNDKCVLRIQCGCKDTQGGLIPAGRTWISSDCTKSCSCMGGIIQCRDFQCPPGTYCKESNDSSRTCAKIPLQCPAHSHYTNCLPACSRSCTDLDGHCEGTSPKVPSPCKEGCLCQPGYVVHNHKCVLQIHCGCKDAQGGFVPAGKTWISRGCTQSCACVGGAVQCHNFTCPTGTQCQNSSCSKITVQCPAHSQYTTCLPSCLPSCFDPEGLCGGASPRAPSTCREGCVCEADYVLREDKCVLRTQCGCKDAQGDLIPANKTWLTRGCAQKCTCKGGNIHCWNFKCPLGTECKDSVDGGSNCTKIALQCPAHSHHTYCLPSCIPSCSNVNDRCESTSLQRPSTCIEGCLCHSGFVFSKDKCVPRTQCGCKDSQGTLIPAGKNWITTGCSQRCTCTGGLVQCHDFQCPSGAECQDIEDGNSNCVEITVQCPAHSHYSKCLPPCQPSCSDPDGHCEGTSPEAPSTCEEGCVCEPDYVLSNDKCVPSSECGCKDAHGVLIPESKTWVSRGCTKNCTCKGGTVQCHDFSCPTGSRCLDNNEGNSNCVTYALKCPAHSLYTNCLPSCLPSCSDPEGLCGGTSPEVPSTCKEGCICQSGYVLHKNKCMLRIHCDCKDFQGSLIKTGQTWISSGCSKICTCKGGFFQCQSYKCPSGTQCEESEDGSSNCVSSTMKCPANSLYTHCLPTCLPSCSNPDGRCEGTSHKAPSTCREGCVCQPGYLLNKDTCVHKNQCGCKDIRGNIIPAGNTWISSDCTQSCACTDGVIQCQNFVCPSGSHCQYNEDGSSDCAANKLERCTIFGDPYYLTFDGFTYHFLGRMNYYLIKTVDKLPRGIEPLIMEGRNKISPKGSSTLHEVTTIVYGYKIQLQEELVVLVNDEKVAVPYNPNEHLRVMLRAQRLLLVTDFEMVLDFDGKHSAVISLPTTYRGLTRGLCGNYDRDQSNELMLPSGVLTSNVHVFGNSWEVKAQHAFFRFPRALPEDEERDEEPDLLQSECSQEQTALISSTQACRVLVDPQGPFAACHQIIAPEPFEQRCMLDMCTGWKTKEEEELRCRVLSGYAIICQEAGANMTGWRDHTHCAMTCPANTVYQRCMTPCPASCAKFVTPKVCEGPCVEGCASLPGYIYSDTQSLPVTHCGCTADGIYYKLGDSFVTNDCSQHCTCASQGILLCEPYGCRAGESCMVANFTRGCFQDSPCLQNPCHNDGRCEEQGATFICHCDFGYGGEFCTEPQDITTRKKIEASSLVAILPGVLVMVLVPVLLPRVYVYMATRTTMGRRRMKRKEKKLLRQSRLRLEDADVPEPTFKATEF