Protein: Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase) (Q9TZM3)
Organism: Caenorhabditis elegans
Function: Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:17346966}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Probable cation-transporting ATPase catp-6
- Glutathione-independent glyoxalase DJR-1.1
- Serine/threonine-protein kinase pink-1, mitochondrial
- Glutathione-independent glyoxalase DJR-1.2
- Vacuolar protein sorting-associated protein 35
- AP-3 complex subunit beta
- D-lactate dehydrogenase
- PIH1 N-terminal domain-containing protein
- Protein YIPF
Sequence:
MDLSSGGPSSSSDVASELDNSDAMQLVRQAVLFENVELLADLFKVNPWVWNRVDRHGRTPLMLAAHNGKLDSLRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDNEGHCALELAQMAGHNEVAAKLIDAIQKESEDLNEAHTMIISACISGSADVVYEISRRFMEKKQSREILFNGRNEEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCLEKFPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFIIEIDTVGAPAYQLALDVNEVDGECRTAMYLAVAEGHLEVVKAMTDFKCTSIDGRQRCPFQLDVYCTRGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLAVLDTEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGALDTDNKALRLAAQGKNEKLIRVFLVRLVFADPEYKINKKNIDVGQIQVGQSLLPSSLCPSKAAQLNWNSANLEQLQSDWFVAAALHVNPRLRTTRLSLAAITRVDLSDNRLNTFPSILFQMPSLRSLNLADNSIRKIEIPTYYISSTSLEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIWLCPALKELNASYNRLSTLPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTSNPLRRQNVWQASINLSKVDDDSLFPDFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSMTSLPPMACVPAHLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRSKSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSISVTNAASKVLLPALNVMDISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKEPLESMVNVENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPIHSETGVIRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQLDTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTRYMVADADKSGLPRIVDVILINSTSRNDVKALLNTIYRTAWEVRMGKERAMEQQIPSSYIALMKVTKELGVEFRKEGQPAVMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLRDLIFVDPLWLAEFLTSVVILRSPNLPAGLLSTDAINPHTRSFKSGALLMLKTQLLDLLHKFELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPLRRTSPTDQNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGHSLFTLKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSSEGDLLVSRYVLCPQCVRDAERNGSRSRTSSSASHRRSQDDGELPITSSSHMKGSRTTGDISKCRGGVVHCFVIEECMLAGREYNWVECPSHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVGITDEIDDPDDFEAQLWLSGREMVVMGCTQYGFVDQKSIELPHRGKYVSKVRDSVWSCDECGQVTVYGISLHETGHLQLPSLNGTLICAPELISNDVLILISDKQIVLLKLSESNSVSHLGTIDSPYEIRTATFLGNGSTRQIWAGHSEGRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQKVWIALEKSSKVQMVEVEKRQVTGSLDIRKVMPGSETIHTIDMEMASQNYVTCIGLLERNDGDQLYIGTSKGLLVIAHATTLQPLSACRPFEGDITSICILEEPSREEENTRGKATTLSTASSESGLGWVRERVSETVDRFRSSPATVETQGAALVVCIGRQFRSLSHRFVAEEKLADVYSIAVWRTEEWAL