wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 33B (Q18891)
Organism: Caenorhabditis elegans
Function: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Most likely within the CORVET complex, it is involved in the fusion of endocytic compartments. Required for sperm development and function.
Subcellular location: Early endosome {ECO:0000269|PubMed:25273556, ECO:0000269|PubMed:27558849}. Late endosome membrane {ECO:0000269|PubMed:27558849}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H267}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H267}. Lysosome membrane {ECO:0000250|UniProtKB:Q9H267}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H267}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H267}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9H267}. Recycling endosome {ECO:0000250|UniProtKB:Q9H267}.
Interaction partners:
- Spermatogenesis-defective protein 39
- Vacuolar protein sorting-associated protein 18 homolog
- Vps8 domain-containing protein
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar fusion protein CCZ1 homolog
- Ras-related protein Rab-7a
- Vacuolar protein sorting-associated protein 41 homolog
- t-SNARE coiled-coil homology domain-containing protein
Sequence:
MAPGTAELEIDETLHLLRMVMQREFIHYLETLPGTKELFIDKCLLRPLDMIATSSDMKRHGVKRIMHFDLQKSPQVWNIEIDQRVFFLRPNVENARKIVEYVEESSENRSICVIWCNRQLEECDLAFESSGVIGHITQLSLNMCLLPLESDLFSLQHVESAQPDLFSVANMFVALQNLYGVIPTVYGLGSESKNLWNLVHALCSSNELRARPDQPISHLFLFDRQLDPVPVLLTGASYEGLLHEFFTIDCGKLAFPVDLRKQVQTGPLDFDWIEINPEEDKEAHQQNRGDTVKLDNCEDIFASIRNKHVTAALEFLHSKAKSIQKSIEKSSMIDDVADYRNFVEKDLRALKKDHKHCELHINACEMMMNKVKMEDYRTMFKLEHEMLLGTVTHEEYFDFVFERVPMRSCRDVVLSMMSLASLKLDGVPDDTYNEFVEMYLQKYGYEHMFELQNLRNSRVIYARRHIAHDRTISERARTWETLARKFRIVKGNEPMDMSNPSDMSYVFGARISPLLCKIVEDTIDHGWNQAEYERIIGKDKVLVEENTYIAADRRPDNRTRKAIMVFVNGGITYWEVAALRLLAIQKNFRILICTTHVIKKREYLEVRAKDASSVFGS
Protein: Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase) (Q388A7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03123}.
Interaction partners:
- Glycine cleavage system H protein
- lipoyl
- Lipoate-protein ligase, putative
Sequence:
MFQRWSFALCRPIVAAAQVSQQQVPPSEEPRNESGAANPPLVKEEFLRQFRERLANDKTGRNSLEGFLDLPENLPPTAASIGPLKRGKEPLPPWLKLKVPMGASRQPRFNKIRRNMREKRLATVCEEAKCPNIGECWGGGDEEGDGTATATIMVMGAHCTRGCRFCSVMTSRTPPPLDPEEPRKTADAVADMGVEYIVMTMVDRDDLADGGAAHVVRCVTAVKERNPGLLLEALVGDFHGDLKLVEMVAGSPLNVYAHNIECVERITPNVRDRRASYRQSLKVLEHVNNFTKGAMLTKSSIMLGLGEKEEEVRQTLRDLRTAGVSAVTLGQYLQPSRTRLKVSRYAHPKEFEMWEKEALDMGFLYCASGPMVRSSYRAGEYYIKNILKQRETVEAPSVSDGGNEPKDSE
Protein: Seed lectin beta chain (P86353)
Organism: Spatholobus parviflorus (Butea parviflora)
Function: Galactose-binding lectin. Agglutinates human erythrocytes, and requires Ca(2+) and Mn(2+) ions for full agglutinating activity. Has antifungal activity against Fusarium sp., A.niger and A.flavus.
Interaction partners:
Sequence:
AEETSFVFSKFKPLEPNLILQGDALVTVAGVLQLTNVDSNGVPEPSSLGRATYSAPINIWDSATGLVASFATSFRFTIYAPNIATIADGLAFFLAPVASAPDSGGGFLGLFDSAVGDTTYQTVAVEFDTYENTVFTDPPYTHIGFDVNSISSIKTVKWSLANGEAAKVLITYNSAVKLLVASLVYPSSKTSFILADIVDLSSVLPEWVRVGFSAATGASKGYIETHDVFSWSFASKLAG
Protein: Paired box protein Pax-9 (P55771)
Organism: Homo sapiens (Human)
Function: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein MSX-1
- Homeobox protein Nkx-2.8
- Lysine-specific demethylase 5B
- Protein Wnt-10a
- Paired mesoderm homeobox protein 2
- Protein odd-skipped-related 2
- LIM/homeobox protein Lhx8
- Ectodysplasin-A
- Bone morphogenetic protein 4
- Pituitary homeobox 2
Sequence:
MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL
Protein: rRNA 2'-O-methyltransferase fibrillarin (Histone-glutamine methyltransferase) (E9QV42)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- 13 kDa ribonucleoprotein-associated protein
- Small nucleolar ribonucleoprotein complex subunit, putative
- Nucleolar protein 56
- U3 small nucleolar RNA-associated protein 22
- Small nucleolar ribonucleoprotein complex subunit, putative
- Nucleolar protein 58
- rRNA processing protein Bystin, putative
- Small nucleolar ribonucleoprotein complex subunit, putative
- U3 small nucleolar RNA-associated protein 10
- U three protein 7
Sequence:
MAFGGPRGGGRGAPRGGRGAPRGGGGRGGRGGLGSGGRGRGGARGGGRGGPARGRGGRGGGRGGAKGAKGGAKVIIEPHRHAGVFVARGGKEDLLVTKNLTPGESVYGEKRIAVESPAGEDGAVTKIEYRVWNPFRSKLAAGILGGLDDIYMKPGSKVLYLGSASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLVPMVDVIFADVAQPDQARIVGLNAHMFLKNEGGVIVSVKANCIDSTAKPEVVFAREVQKMREEKIKPKEQLTLEPFERDHCIVSGIYKRSA
Protein: Phosphodiesterase (EC 3.1.4.-) (Q38F42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenosine kinase
- Adenosine kinase
- AMP deaminase
- Adenosine monophosphate deaminase, putative
- AMP deaminase, putative
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Phosphodiesterase
- Adenylosuccinate lyase
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
Sequence:
MTHNGGRHLLEAVTLCGSILTRYKRSNMKLDEAEVRALKELFEKYQDILVDGSPGLPTHASGPMIQPPVTNMVAPYDSPTDTIVKFVEGTINLQRPIVEVLHVMNEHLSLVLRAKNTHVFYVDPVNNLLYDPIHGVAAALDESSPIGKAIVSGERLNVAGTLYIPIISEGMPLGCVLSPCGRADYHASTMLESSLRVISTSLKNIIQAEKLNWNKEKAEAMLRMATQLARDNLEETVLASSIMNTVKSLTESARCSLFLVRGDVLEAHFEDGNVVTIPRGAGIAGYVAQTGETVNIVDAYADDRFNREVDKATGYRTKTILCMPVMYEGTIVAVAQLINKLDLTTESGLRLPRVFGRRDEELFQTFSMFAGASLRNCRINDRLLKEKKKSDVILDVVTVLSNTDIRDVDGIVRHALHGAKKLLNADRSTLFLVDKERNELCSRMADSVAGKEIRFPCGQGIAGTVAASGVGENIQDAYQDPRFNREVDKQLGYRTQAILCEPIILNGEILAVVQLVNKLDSSGEVTVFTEDDRDTFRVFSLFAGISINNSHLLEFAVKAGREVMELNEHRATLFNKNVPSRGVKRVTAITNREREAVLRIEFPNVDVTDIDFDLFQARESTDKPLDVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIYTFLYRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSASGNKSVLEVHHCNLAVEILSDPESDVFGGLEGAERTLAFRSMIDCVLATDMARHSEFLEKYLELMKTSYNVDDSDHRQMTMDVLMKAGDISNVTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRTKSNRAQWERVLEARSTGASS
Protein: LOB domain-containing protein 37 (ASYMMETRIC LEAVES 2-like protein 39) (AS2-like protein 39) (Q9FN11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein NLP7
- Protein NLP6
- MADS-box transcription factor ANR1
- Nitrate reductase 2
- Transcription factor HRS1
- Transcription factor HHO1
- Transcription factor TGA4
- Nitrate reductase 1
- Transcription factor TGA1
- At1g71030/F23N20_2
Sequence:
MSCNGCRVLRKGCSENCILRPCIQWIETADAQGHATVFVAKFFGRAGLMSFISAVPDSQRPALFQSLLYEACGRTVNPVNGAIGMLWTGNWNICQAAVETVLRGGSLRPIPELLTHGGGFAGFPSPTSEEASEICTEMLNLQQNDSTDRNIYHHSRFSSSRSRSTMDSSSPTKRKRLSSEDQPSSELDLSLIPNFPIKQATPSSTRRRSVTPSMNSEDSGTTTTTTAFCDKGDVYGNGGGETTKLLNLFV
Protein: Uncharacterized protein YdbH (P52645)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Protein AsmA
- Probable chaperone-like protein YdbL
- Outer membrane lipoprotein YnbE
- Intermembrane phospholipid transporter YhdP
- AsmA family protein YicH
- AsmA family protein YhjG
- Translocation and assembly module subunit TamB
- Phosphotransferase RcsD
- Protein YdgA
- Chaperone protein YcdY
Sequence:
MLGKYKAVLALLLLIILVPLTLLMTLGLWVPTLAGIWLPLGTRIALDESPRITRKGLIIPDLRYLVGDCQLAHITNASLSHPSRWLLNVGTVELDSACLAKLPQTEQSPAAPKTLAQWQAMLPNTWINIDKLIFSPWQEWQGKLSLALTSDIQQLRYQGEKVKFQGQLKGQQLTVSELDVVAFENQPPVKLVGEFAMPLVPDGLPVSGHATATLNLPQEPSLVDAELDWQENSGQLIVLARDNGDPLLDLPWQITRQQLTVSDGRWSWPYAGFPLSGRLGVKVDNWQAGLENALVSGRLSVLTQGQAGKGNAVLNFGPGKLSMDNSQLPLQLTGEAKQADLILYARLPAQLSGSLSDPTLTFEPGALLRSKGRVIDSLDIDEIRWPLAGVKVTQRGVDGRLQAILQAHENELGDFVLHMDGLANDFLPDAGRWQWRYWGKGSFTPMNATWDVAGKGEWHDSTITLTDLSTGFDQLQYGTMTVEKPRLILDKPIVWVRDAQHPSFSGALSLDAGQTLFTGGSVLPPSTLKFSVDGRDPTYFLFKGDLHAGEIGPVRVNGRWDGIRLRGNAWWPKQSLTVFQPLVPPDWKMNLRDGELYAQVAFSAAPEQGFRAGGHGVLKGGSAWMPDNQVNGVDFVLPFRFADGAWHLGTRGPVTLRIAEVINLVTAKNITADLQGRYPWTEEEPLLLTDVSVDVLGGNVLMKQLRMPQHDPALLRLNNLSSSELVSAVNPKQFAMSGAFSGALPLWLNNEKWIVKDGWLANSGPMTLRLDKDTADAVVKDNMTAGSAINWLRYMEISRSSTKINLDNLGLLTMQANITGTSRVDGKSGTVNLNYHHEENIFTLWRSLRFGDNLQAWLEQNARLPGNDCPQGKECEEKQ
Protein: Multifunctional Ser/Thr-tRNA deacylase ProXp-y (EC 3.1.1.-) (Free-standing editing domain ProXp-y) (Homologous trans-editing factor ProXp-y) (ProXp-ST1) (Prolyl-tRNA synthetase insertion domain homolog ProXp-y) (ProRS INS domain homolog ProXp-y) (P64483)
Organism: Escherichia coli (strain K12)
Function: An aminoacyl-tRNA editing enzyme that deacylates Ser-tRNA and/or Thr-tRNA mischarged by lysyl-tRNA synthetase (LysRS), threonyl-tRNA synthetase (ThrRS), seryl-tRNA synthetase (SerRS), alanyl-tRNA synthetase (AlaRS), valyl-tRNA synthetase (ValRS) and isoleucyl-tRNA synthetase (IleRS) in vitro. Deacylates also mischarged Hse-tRNA(Lys) and Hse-tRNA(Ser), and cognate Ser-tRNA(Ser) and Thr-tRNA(Thr) in vitro. The presence of cognate ThrRS abolishes the Thr-tRNA(Thr) deacylase activity, hence this activity is not applicable physiologically. Not able to remove the amino acid moiety from cognate Val-tRNA(Val), Ile-tRNA(Ile), Lys-tRNA(Lys), Ala-tRNA(Ala) or Pro-tRNA(Pro), or from incorrectly charged Ala-tRNA(Pro), Cys-tRNA(Pro) or Leu-tRNA(Pro) in vitro. May be required in vivo to prevent mistranslation and to maintain growth when the error prone stress-inducible lysyl-tRNA synthetase (LysU) is expressed under environmental pressure.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Cys-tRNA
Sequence:
MTEMAKGSVTHQRLIALLSQEGADFRVVTHEAVGKCEAVSEIRGTALGQGAKALVCKVKGNGVNQHVLAILAADQQADLSQLASHIGGLRASLASPAEVDELTGCVFGAIPPFSFHPKLKLVADPLLFERFDEIAFNAGMLDKSVILKTADYLRIAQPELVNFRRTA
Protein: Mitochondrial import inner membrane translocase subunit TIM22 (Q12328)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins, such as mitochondrial carrier family members, into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps. Mediates the insertion of precursor proteins in a 3 step process. After the precursor is tethered to the translocase without losing energy from the Delta(psi), 2 energy-requiring steps are needed. First, Delta(psi) acts on the precursor protein and promotes its docking in the translocase complex. Then, Delta(psi) and an internal signal peptide together induce rapid gating transitions in one pore and closing of the other pore and drive membrane insertion to completion.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10397776, ECO:0000269|PubMed:8955274, ECO:0000305|PubMed:27265872}; Multi-pass membrane protein {ECO:0000269|PubMed:10397776, ECO:0000269|PubMed:8955274}. Note=Import into inner membrane protein requires TOM20 function.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM18
- Mitochondrial import inner membrane translocase subunit TIM54
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM12
- Mitochondrial import inner membrane translocase subunit TIM10
- Succinate dehydrogenase cytochrome b subunit
- Mitochondrial import inner membrane translocase subunit TIM23
- Truncated non-functional calcium-binding mitochondrial carrier SAL1-1
- Adrenodoxin homolog, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM17
Sequence:
MVYTGFGLEQISPAQKKPYNELTPEEQGERGAEMIMNFMTSCPGKSVVSGVTGFALGGVLGLFMASMAYDTPLHTPTPANTAATATAGNIGVGGISRTVQQISDLPFRQQMKLQFTDMGKKSYSSAKNFGYIGMIYAGVECVIESLRAKNDIYNGVTAGFFTGAGLAYKAGPQAALMGGAGFAAFSAAIDLYMKSEDGRPPQNDFKE
Protein: Glutathione S-transferase (EC 2.5.1.18) (Q5JW85)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAKIALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPLLKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF
Protein: Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR) (G-protein coupled receptor GPCR135) (Relaxin family peptide receptor 3) (Somatostatin- and angiotensin-like peptide receptor) (Q9NSD7)
Organism: Homo sapiens (Human)
Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Relaxin-3
- Relaxin receptor 1
- Relaxin receptor 2
- Prorelaxin H1
- Insulin-like peptide INSL5
- Prorelaxin H2
- Beta-arrestin-2
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Insulin-like 3
Sequence:
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
Protein: Mast cell protease 3 (Q9Z1D3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
SLLLPSGAGAEEIIGGVESIPHSRPYMALLKIVTEEGHVTFCGGFLISHLFVMTAAHCRGKEITVILGAHDMSKRESTQQKIKVEKQIFYPKYNFFSNFHDIMLLKLEEKAVLTPTVNVIPLPQSSDFIKPGKMCWAAGWGRTGVTEPTSDTLREVKLRIMEKKACWYFWHYDNRFQICVGSPEMLKLTYKEDSGGPLVCAGVAHGIVSHGRGRGKPPIIFTRISSYVPWIDTVIKGN
Protein: Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) (O35594)
Organism: Mus musculus (Mouse)
Function: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling (By similarity). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19253336}. Cytoplasm {ECO:0000269|PubMed:32233951}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8WYA0}.
Interaction partners:
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 88 homolog
- TRAF3-interacting protein 1
Sequence:
MSDQIKFIVDSLNKEPFKKNYNLITFDSLGPMQLLQVLNDVLAEIDPKQDVDIREEMPEQTAKRMLNLLGILKYKPPGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRSNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKECEQLKTSGFSTAEIRRDISAMEEEKDQLMKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRHAAADAKPESLMKRLEEEIKFNSYMVTEKFPKELESKKKELHFLQKVVSEPAMGHSDLLELETKVNEVNTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQETKEKLASLEREVLVKTNQTREFDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRQETIQHQLRTIEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPVIKELRQLRQKCQELTQECDEKKAQYDSCAAGLESNRSKLEQEVRGLREECLQEESKYHYTNCMIKNLEVELRRATDEMKAYVSSDQQEKRKAIREQYTKNITEQENLGKKLREKQKAVRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSPASIGQVIQEGGEDRLVL
Protein: C-C motif chemokine 6 (Small-inducible cytokine A6) (Q68FP3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Macrophage inflammatory protein-1 alpha receptor
- C-C motif chemokine 2
- C-C motif chemokine
- C-C motif chemokine ligand 24
- C-C motif chemokine 5
- C-C chemokine receptor type 3
- C-C motif chemokine 7
- Chemokine
- Eotaxin
- C-C motif chemokine ligand 27
Sequence:
MRHSKTAISFFILVAVLGSQAGLIQDTVKEDRPFNPTIIHQGFQDSSDCCFSYASQIPCSRFIYYFPTSGGCTKPGIIFVTRKRKRVCANPSDQRVQTCISTLKLGPRSGNSAIA
Protein: Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1) (P56163)
Organism: Rattus norvegicus (Rat)
Function: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Actin-like protein 6B
- Double PHD fingers 3
- AT-rich interaction domain 1A
- AT-rich interaction domain 1B
- Calcium-responsive transcription coactivator
- PHD finger protein 10
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
- Actin-like protein 6A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Sequence:
MATVIPSPLSLGEDFYREAIEHCRSYNARLCAERSLRLPFLDSQTGVAQNNCYIWMEKTHRGPGLAPGQIYTYPARCWRKKRRLNILEDPRLRPCEYKIDCEAPLKKEGGLPEGPVLEALLCAETGEKKVELKEEETIMDCQKQQLLEFPHDLEVEDLEEDIPRRKNRAKGKAYGIGGLRKRQDNASLEDRDKPYVCDICGKRYKNRPGLSYHYTHTHLAEEEGEEHTERHALPFHRKNNHKQFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDGASWAGLTPQDQLLFCDDCDRGYHMYCLSPPMAEPPEGSWSCHLCLRHLKEKASAYITLT
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q585I6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein phosphatase 2C, putative
- Phosphotyrosine protein phosphatase I domain-containing protein
Sequence:
MTLVQTLLERMLSAKGNTAQRQILIREEDIRTILNAVRDVFMSQPVVLDITPPVRICGDIHGQYYDLLRVFEKCGFPPYSNYLFLGDYVDRGRHSVETITLLFCYKIVYPENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVVGEKIICMHGGLSPDMTSLAAVNEIERPLDVPDKGILCDLLWADPEEEVKGFLESDRGVSYLFGEDIVTDFLDMVDMDLVVRAHQVMERGYGFFANRQLVTIFSAPNYCGEFDNDAAVMNVDEKLQCSFAIIAAR
Protein: Iron transport multicopper oxidase FET5 (EC 1.-.-.-) (P43561)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Iron transporter FTH1
- Iron transporter SMF3
- Plasma membrane iron permease
- Protein CCC1
- Ferric reductase transmembrane component 6
- Ferric/cupric reductase transmembrane component 1
- Copper-transporting ATPase
- Iron-regulated transcriptional activator AFT1
- Iron-regulated transcriptional activator AFT2
- Siderophore iron transporter ARN1
Sequence:
MLFYSFVWSVLAASVALAKTHKLNYTASWVTANPDGLHEKRMIGFNGEWPLPDIHVEKGDRVELYLTNGFQDNTATSLHFHGLFQNTSLGNQLQMDGPSMVTQCPIVPGQTYLYNFTVPEQVGTFWYHAHMGAQYGDGMRGAFIIHDPEEPFEYDHERVITLSDHYHENYKTVTKEFLSRYNPTGAEPIPQNILFNNTMNVTLDFTPGETYLFRFLNVGLFVSQYIILEDHEMSIVEVDGVYVKPNFTDSIYLSAGQRMSVLIKAKDKMPTRNYAMMQIMDETMLDVVPPELQLNQTIQMRYGHSLPEARALNIEDCDLDRATNDFYLEPLIERDLLAHYDHQIVMDVRMVNLGDGVKYAFFNNITYVTPKVPTLTTLLTSGKLASDPRIYGDNINAQLLKHNDIIEVVLNNYDSGRHPFHLHGHNFQIVQKSPGFHVDEAYDESEQDEMTVPYNESAPLQPFPERPMVRDTVVLEPSGHVVLRFRADNPGVWYFHCHVDWHLQQGLASVFIEAPVLLQEREKLNENYLDICKAADIPVVGNAAGHSNDWFDLKGLPRQPEPLPKGFTTEGYLALIISTIIGVWGLYSIAQYGIGEVIPNDEKVYHTLREILAENEIEVSRG
Protein: DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) (P33992)
Organism: Homo sapiens (Human)
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- Origin recognition complex subunit 5
- DNA replication licensing factor MCM4
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM7
- Cell division cycle 7-related protein kinase
- DNA replication complex GINS protein PSF1
- DNA replication factor Cdt1
- Origin recognition complex subunit 2
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
Sequence:
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGEIQHRMQRKVLYRLK