wanglab/gogpt-training-data huggingface dataset:
Protein: Pheophytinase, chloroplastic (EC 3.1.1.-) (Pheophytin pheophorbide hydrolase) (Protein CO-REGULATED WITH NYE1) (Q9FFZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Alpha/beta hydrolase dephytylating specifically the Mg-free chlorophyll pigment (pheophytin), yielding pheophorbide. No activity on chlorophyll. Belongs to the chlorophyll catabolic enzymes (CCEs).
Subcellular location: Plastid, chloroplast thylakoid membrane. Plastid, chloroplast stroma.
Interaction partners:
- Pheophorbide a oxygenase, chloroplastic
- Probable chlorophyll
- Chlorophyll
- Red chlorophyll catabolite reductase, chloroplastic
- Magnesium dechelatase SGR1, chloroplastic
- Chlorophyllase-1
- Chlorophyllase-2
- AP-4 complex subunit mu
- 7-hydroxymethyl chlorophyll a reductase, chloroplastic
- Chlorophyllide a oxygenase, chloroplastic
Sequence:
MEIISLNVVPQCSVVTWSSKLATKRLVPNRSSLLFSGVKKSRLVIRSGNSDGYVVGENDDLGRIARRGESTSKVLIPGLPDESNGEIAARISHSHCEWKPKLRVHYEKAGCDNLDAPAVLFLPGFGVGSFHYEKQLTDLGRDYRVWAIDFLGQGLSLPTEDPTTMTEETSSSEDKEPFWGFGDKTEPWADQLVFSLDLWRDQVQYFVEEVIGEPVYIAGNSLGGYVALYFAATHPHLVKGVTLLNATPFWGFFPNPVRSPKLARLFPWPGAFPLPERVKKITELVWQKISDPESIAEILKQVYTDHSINVDKVFSRIVEVTQHPAAAASFASIMLAPGGELSFSEALSRCKENNVQICLMYGREDPWVRPLWGKKIKKEIPNAPYYEISPAGHCPHDEVPEVVNYLMRGWIKHLESGGFEALPLLEDTEEDWEESRIGREIEFPRDGWKKAVNLWLYGSNYTYWRGVRESFRSSFIRVFGGKSA
Protein: Spindle assembly checkpoint component MAD2 (Q59VQ3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P40958}.
Interaction partners:
- Bub3p
- Spindle assembly checkpoint component MAD1
- Protein kinase
- Anaphase promoting complex subunit
- Anaphase promoting complex subunit
- Anaphase-promoting complex subunit 4
- Ubiquitin-protein transferase activating protein
- Anaphase promoting complex subunit
- Anaphase promoting complex subunit 1
- Serine/threonine/tyrosine protein kinase
Sequence:
MPSSLEPSSKLALKGSSKIVCDYFEFALNSILYQRGIYPQEDFVTVKKYDLPMVINDDYDVQKYINNIMKQIKKWIYGSLMSKFIIVIVSKTNLENIERWEFNIETKDQEETTENGDGDGDGVGKSRQEIQKEIRTIIRQITSSVSYLPVLKDDDEYTFNVLVYTDPNTSVPIEWCDTQGDGKVLDGDNVDNVKFTSFSTDIHQVGTSVSYKYE
Protein: GATA transcription factor 19 (Protein HAN-LIKE 2) (Q6QPM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. Regulates both flower and shoot apical meristem (SAM) development, especially for establishing organ boundaries in shoots and flowers, probably by controlling the number and position of WUS-expressing cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein-S-isoprenylcysteine O-methyltransferase B
- UPF0496 protein At3g49070
Sequence:
MGFSMFFSPENDVSHHSSPYASVDCTLSLGTPSTRLCNEDDERRFSSHTSDTIGWDFLNGSKKGGGGGGHNLLARRCANCDTTSTPLWRNGPRGPKSLCNACGIRFKKEERRASTARNSTSGGGSTAAGVPTLDHQASANYYYNNNNQYASSSPWHHQHNTQRVPYYSPANNEYSYVDDVRVVDHDVTTDPFLSWRLNVADRTGLVHDFTM
Protein: LD40262p (Q7JQY8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
Sequence:
MALNKRKSPYSDPISGAEVDYKLSCRCCLKTNVEYVKLDSVSVARSLDPADATEKIPLLRCLLFCVSADNAPELPQHICLECSKSLQVAYYFLQNALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAEPVQPLKTMRHECQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHYVTMHNMPLSQAEEYVKSKHLPAPKEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPHIDNDQLRDIDHQLAVSMDEPVPSVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVNGSGVVIEYIDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSNLPKFFCDQCDFYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENLFEDFEEEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPYCIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKSQCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHALIIHDLRFTTEELGNLSSLATNQARPNDLKVATPVGLLDGRKDVSGASEENGQP
Protein: Gamma-tubulin complex component 3 (Gamma-ring complex protein 91 kDa) (Q9XYP8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:32066907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32066907}. Note=In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs). {ECO:0000269|PubMed:32066907}.
Interaction partners:
- Grip163
- Gamma-tubulin complex component
- Gamma-tubulin complex component 2 homolog
- Gamma-tubulin complex component 4 homolog
- Tubulin gamma-1 chain
- Tubulin gamma-2 chain
- Grip71
- Gamma-tubulin complex component
- GEO02508p1
- Testis-specific gamma-tubulin ring protein 128
Sequence:
MSQDRIAGIDVATNSTDISNIINEMIICIKGKQMPEVHEKAMDHLSKMIAANSRVIRDSNMLTERECVQKIMKLLSARNKKEEGKTVSDHFNELYRKLTLTKCDPHMRHSLMTHLLTMTDNSDAEKAVASEDPRTQCDNLTQILVSRLNSISSSIASLNEMGVVNGNGVGAAAVTGAAAVTGAAAVTGAAAVTGAAASHSYDATQSSIGLRKQSLPNYLDATKMLPESRHDIVMSAIYSFTGVQGKYLKKDVVTGRFKLDQQNIKFLTTGQAGMLLRLSELGYYHDRVVKFSDVSTGFNAIGSMGQALISKLKEELANFHGQVAMLHDEMQRFRQASVNGIANKGKKDSGPDAGDEMTLFKLLAWYIKPLHRMQWLTKIADACQVKKGGDLASTVYDFLDNGNDMVNKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKSIKDVGVDRLWHDKFRLRLPMLPKFVPMDMANKILMTGKSINFLREICEEQGMMKERDELMKVMESSASQIFSYTPDTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISILIENMKNELERPGLDIYANDLTSMLDSALRCTNAQYDDPDILNHLDVIVQRPFNGDIGWNIISLQYIVHGPLAAMLESTMPTYKVLFKPLWRMKHMEFVLSMKIWKEQMGNAKALRTMKSEIGKASHRLNLFTSEIMHFIHQMQYYVLFEVIECNWVELQKKMQKATTLDEILEAHEKFLQTILVGCFVSNKASVEHSLEVVYENIIELEKWQSSFYKDCFKELNARKELSKIVEKSEKKGVYGLTNKMILQRDQEAKIFAEKMDIACRGLEVIATDYEKAVSTFLMSLNSSDDPNLQLFGTRLDFNEYYKKRDTNLSKPLTFEHMRMSNVFAVNSRFVICTPSTQE
Protein: Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) (Q15388)
Organism: Homo sapiens (Human)
Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101, ECO:0000269|PubMed:31644573}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM5 homolog
- Mitochondrial import receptor subunit TOM6 homolog
- Serine/threonine-protein kinase PINK1, mitochondrial
- Alpha-synuclein
- Non-selective voltage-gated ion channel VDAC1
- Sorting and assembly machinery component 50 homolog
Sequence:
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
Protein: Ataxin 2 (F8W0B5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGVFILSFISFVLSGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQYKPTTNSSCKAALEEPKGQIPSSLLLLLPTGSTEN
Protein: UDP-glucosyltransferase 2 (DcUGT2) (EC 2.4.1.-) (A0A291PQH4)
Organism: Dactylopius coccus (Cochineal)
Function: Membrane-bound UDP-glucosyltransferase (UGT) which catalyzes the C-glucosylation of kermesate and flavokermesate to produce carminate and flavokermesate 7-C-beta-D-glucoside (dcll) respectively. Carminate is used as a deterrent against insect predators.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29215010}; Single-pass type I membrane protein {ECO:0000305}. Note=Localization to the endoplasmic reticulum membrane is critical for its activity. {ECO:0000269|PubMed:29215010}.
Interaction partners:
Sequence:
MEFRLLILALFSVLMSTSNGAEILALFPIHGISNYNVAEALLKTLANRGHNVTVVTSFPQKKPVPNLYEIDVSGAKGLATNSIHFERLQTIIQDVKSNFKNMVRLSRTYCEIMFSDPRVLNIRDKKFDLVINAVFGSDCDAGFAWKSQAPLISILNARHTPWALHRMGNPSNPAYMPVIHSRFPVKMNFFQRMINTGWHLYFLYMYFYYGNGEDANKMARKFFGNDMPDINEMVFNTSLLFVNTHFSVDMPYPLVPNCIEIGGIHVKEPQPLPLEIQKFMDEAEHGVIFFTLGSMVRTSTFPNQTIQAFKEAFAELPQRVLWKFENENEDMPSNVLIRKWFPQNDIFGHKNIKAFISHGGNSGALEAVHFGVPIIGIPLFYDQYRNILSFVKEGVAVLLDVNDLTKDNILSSVRTVVNDKSYSERMKALSQLFRDRPMSPLDTAVYWTEYVIRHRGAHHLKTAGAFLHWYQYLLLDVITFLLVTFCAFCFIVKYICKALIHHYWSSSKSEKLKKN
Protein: Epithelial membrane protein 3 (EMP-3) (Hematopoietic neural membrane protein 1) (HNMP-1) (Protein YMP) (P54852)
Organism: Homo sapiens (Human)
Function: Probably involved in cell proliferation and cell-cell interactions.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Galectin-1
- Lens fiber membrane intrinsic protein
Sequence:
MSLLLLVVSALHILILILLFVATLDKSWWTLPGKESLNLWYDCTWNNDTKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYAIHAEEILEKHPRGGSFGYCFALAWVAFPLALVSGIIYIHLRKRE
Protein: Menage a trois, isoform D (A0A0B4LF49)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLEAVMASDINWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQLVKSNEPLGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKQNDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWVQ
Protein: Cytokinin dehydrogenase 5 (EC 1.5.99.12) (Cytokinin oxidase 5) (AtCKX5) (AtCKX6) (CKO5) (Q67YU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group (By similarity). In association with CKX3 regulates the activity of the reproductive meristems, flower organ size and ovule formation.
Subcellular location: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Adenylate isopentenyltransferase 5, chloroplastic
- Adenylate isopentenyltransferase 3, chloroplastic
- Adenylate isopentenyltransferase 7, mitochondrial
- Cytokinin hydroxylase
- Histidine kinase 4
- Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG3
- Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG1
- Cytokinin hydroxylase
- Adenylate isopentenyltransferase 8, chloroplastic
- Histidine kinase 3
Sequence:
MNREMTSSFLLLTFAICKLIIAVGLNVGPSELLRIGAIDVDGHFTVHPSDLASVSSDFGMLKSPEEPLAVLHPSSAEDVARLVRTAYGSATAFPVSARGHGHSINGQAAAGRNGVVVEMNHGVTGTPKPLVRPDEMYVDVWGGELWVDVLKKTLEHGLAPKSWTDYLYLTVGGTLSNAGISGQAFHHGPQISNVLELDVVTGKGEVMRCSEEENTRLFHGVLGGLGQFGIITRARISLEPAPQRVRWIRVLYSSFKVFTEDQEYLISMHGQLKFDYVEGFVIVDEGLVNNWRSSFFSPRNPVKISSVSSNGSVLYCLEITKNYHDSDSEIVDQEVEILMKKLNFIPTSVFTTDLQYVDFLDRVHKAELKLRSKNLWEVPHPWLNLFVPKSRISDFDKGVFKGILGNKTSGPILIYPMNKDKWDERSSAVTPDEEVFYLVALLRSALTDGEETQKLEYLKDQNRRILEFCEQAKINVKQYLPHHATQEEWVAHFGDKWDRFRSLKAEFDPRHILATGQRIFQNPSLSLFPPSSSSSSAASW
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (G3V4U9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSD
Protein: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15) (Trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (O74932)
Organism: Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Function: Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. The disaccharide trehalose serves as a storage carbohydrate that is mobilized during spore germination.
Interaction partners:
- YALI0D14476p
- YALI0E31086p
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen [starch] synthase
- YALI0C21065p
- Trehalase
- 1,3-beta-glucan synthase
- 1,3-beta-glucan synthase
Sequence:
MPNVLVISNRLPVTISREEDGTYKYTMSSGGLVTALSGLKQSTTFQWFGWPGLEIPEKDKPRLINDLETMFSCVPVFMDDDLADLHYNGFSNSILWPLFHYHPGEMNFDQVAWEAYTQANRLFAKKVASIVKPGDIVWVHDYHLMLLPEMLREECENNSALDGLKIGFFLHTPFPSSEIYRILPVRKEVLTGVLSCNLIGFHTYDYARHFLSSVSRILDLETMPNGTYYKGRHVVVGAFPIGIDVNKFLEGCKRPAVQERIAQLQDKFKGIKVVVGVDRLDYIKGVPQKLHAFEVFLSEHPEWIGKVVLVQVAVPSRGLVEEYQNLRAVVNELVGRINGMFGTVEFTPIHFMHRSVDFNELIALYSISDVCFVSSTRDGMNLVSYEYVACQTEKHGSLILSEFTGAAQSLNGALIVNPWNTEDMAEALYDSLTFSPEKKAENHRKLFKYVSKYTSQHWGEAFVSELKRC
Protein: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) (Q9NHF1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186, ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|HAMAP-Rule:MF_03023}. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. {ECO:0000256|HAMAP-Rule:MF_03023}.
Interaction partners:
Sequence:
MSITLLRGGKQKTTTCVGMTVMAKTTFEEICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAIQRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPPPTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPSGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVAREEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFGSS
Protein: Cdc25-like protein phosphatase twine (EC 3.1.3.48) (Q03019)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required during meiosis. Regulates the transition from the extended G2 phase to the onset of the first meiotic division.
Interaction partners:
- Serine/threonine-protein kinase grp
- Serine/threonine-protein kinase polo
- Ovarian-specific serine/threonine-protein kinase Lok
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B
- Origin recognition complex subunit 3
- Origin recognition complex subunit 5
- Origin recognition complex subunit 2
- Protein boule
- 14-3-3 protein zeta
Sequence:
MASKRLMLDVEEEDDESGACGQENFDPHDADMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPITELSQNMNGARLDGTPKSTQRIPANRTLNNFNSLSSRTLGSFSSSCSSYESGNSLDDEYMDMFEMESAENHNLELPDDLEVLLSGQLKSESNLEEMSNKKGSLRRCLSMYPSEQPEEAVQEPDQETNMPMKKMQRKTLSMNDAEIMRALGDEPELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAFPTLTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLAPAHNDEFRYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRLLYAE
Protein: Acyl-lipid (8-3)-desaturase B (EC 1.14.19.30) (Delta(5) fatty acid desaturase B) (Delta-5 fatty acid desaturase B) (O96099)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Fatty acid desaturase that introduces a cis double bond at the 5-position in 18-carbon polyunsaturated fatty acids.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Diacylglycerol O-acyltransferase 1
Sequence:
MMETNNENKEKLKLYTWDEVSKHNQKNDLWIIVDGKVYNITKWVPLHPGGEDILLLSAGRDATNLFESYHPMTDKHYSLIKQYEIGYISSYEHPKYVEKSEFYSTLKQRVRKHFQTSSQDPKVSVGVFTRMVLIYLFLFVTYYLSQFSTDRFWLNCIFAVLYGVANSLFGLHTMHDACHTAITHNPMTWKILGATFDLFAGASFYAWCHQHVIGHHLYTNVRNADPDLGQGEIDFRVVTPYQARSWYHKYQHIYAPILYGVYALKYRIQDHEIFTKKSNGAIRYSPISTIDTAIFILGKLVFIISRFILPLIYNHSFSHLICFFLISELVLGWYLAISFQVSHVVEDLQFMATPEIFDGADHPLPTTFNQDWAILQVKTTQDYAQDSVLSTFFSGGLNLQVIHHCFPTIAQDYYPQIVPILKEVCKEYNVTYHYKPTFTEAIKSHINYLYKMGNDPDYVRKPVNKND
Protein: Phosphatidic acid phospholipase A1, isoform B (EC 3.1.1.-, EC 3.1.1.32) (Phosphatidic acid phospholipase A1, isoform E) (M9MRD9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASASSEKGQVATPPVAIPYSPVVAHWFYKRSVDTKFIWTPFSHYDSALLETSLNLDDSTLIIPVEGGRYDVNIKERTKTPVYWEGKAIEVRRCSWFYKGVDSKYVPYTEDTAALLEAEYKRSAETGEWHQKIMLANGEQVVFHGPTVIVHFLPQQNADTWGASTQGSMRPRVVKRDLDDFTIEQGESQRVDHLLFMVHGIGSACDLKMRSVEEVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIPRLRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCHQEPLKESEEENKENPDQLPQKQSSQKVQLPTSDPLPKQVSYAMGPEGTGQPVITYTQLIFHPKKFFALGSPIGMFVTIRGIDKLGLDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDFPLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIYASLGISTDSQVPQSSMTIERPVSHESSVSHSLLPM
Protein: Expansion, isoform B (FI03466p) (A1Z8R0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVSRRKILSRSRDDLNLDQTFTQQEEEEDIWFQKDKLYKEHIQEVLDKWTQIDDEIWAKVIVFERNRRVAKAYARAPVLTINGSDDGFDGMRIGLCGFDNPMRDQKTDEMKRVIGQGVKIKMDDAGNILIRRYAKSNVYVKSTASSPNEETSIGAEILKLPNQALESEKIVKLFDMKKFQSNVNRELRRAYPDRRRLETQCLSAVAFVKSENDILECPIWVLIVNVVAMDMLKSKLPPVQRPIVDIKNRPRIPIPDEDPYSVAGNGSGGSSGSSGFGSGHQAQLHPQQQLGKHLNGNGGGHVAATREQLLLQTQQLAHKRSEKPPKLPPRDNIYSHDLIPKPDYDDIDLETRIKLSRGKSDKGKDNKKYDDPYYCGLRARVPNFVKSGKPIPAQVAKDQRDGNGNNIGNGGISTLSQKKTSMIHNHLGGMHPHHIQQQQLMAAAAAAHAAQHHHAGHQREQQQHHQIWQTRSYESGIDSELVESPYNHIYGRHLPLPTRGYVPTPRMFIGEWD
Protein: Large ribosomal subunit protein mL41 (39S ribosomal protein L41, mitochondrial) (L41mt) (MRP-L41) (Q9CQN7)
Organism: Mus musculus (Mouse)
Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q8IXM3}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein uS12m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL30m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL16m
Sequence:
MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGIYTSDRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFQETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR
Protein: Perilipin-4 (Adipocyte protein S3-12) (Q96Q06)
Organism: Homo sapiens (Human)
Function: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O88492}. Cytoplasm {ECO:0000250|UniProtKB:O88492}. Lipid droplet {ECO:0000250|UniProtKB:O88492}. Note=Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent. {ECO:0000250|UniProtKB:O88492}.
Interaction partners:
- Perilipin-1
- Lipid transferase CIDEC
- Hormone-sensitive lipase
Sequence:
MSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAPWTEKELQPSEKMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLATTHGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ
Protein: Transcription factor SOX (A0A8I5ZQY6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038098}.
Interaction partners:
Sequence:
MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHMADYPDYKYRPRKKVKSGNTGAGSAATAKPGEKGDKVAGGSGHAGSGHAGGGAGGSSKPAPKKSCGPKVAGSSVGKPHAKFVPAGGGKAAASFSPEQAALLPLGEPAAVYKVRTPSAATPAASSSPSSALATPAKHPADKKVKRVYLFGSLGASASPVGGLGASADPSDPLGLYEDGGPGCSPDGRSLSGRSSAASSPAASRSPADHRGYASLRAASPAPSSAPSHASSSLSSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY
Protein: Uncharacterized plasma membrane protein YNL194C (P40169)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in sporulation and affects the sphingolipid composition of the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11784867, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:11784867, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YNL195C
- Non-classical export protein 2 homolog 1
- Non-classical export protein 2
- Protein PUN1
- Stationary phase protein 4
- SUR7 family protein FMP45
Sequence:
MSYKKFVYFINLFFLLGATLLTFFLILAGGRTTGVLKNFYWFQASTSGFNSAPSVTRWYNYNWCGWESRGIAVNCSSKMAAQPFSPRDNFGSSPLMPSTFLNNRNAYYYLSRVGWAMLLIGLFFLLITLVSVIASLIRYNRRTAALATAMSWITLFFITLSACLYTGCYAKAVKAFHHENRDARLGPKNFGLIWTTVFLLIVNAICCTIMVATHKRNEYIYDRSFASTKTVDSQTPTPVPTNGGIPSSVPVTEVQQSQSHQNHRFFKKLRTKKRTVTSAGDEPDRVQEERVYTEQNVPVVS