wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase KIPK2 (EC 2.7.11.1) (Q9SJM3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein kinase that could be involved in the negative regulation of root growth.
Interaction partners:
- Proline-rich receptor-like protein kinase PERK8
- Proline-rich receptor-like protein kinase PERK10
- Proline-rich receptor-like protein kinase PERK9
- Proline-rich receptor-like protein kinase PERK13
- Putative proline-rich receptor-like protein kinase PERK11
- Kinesin-like protein KIN-14E
- Proline-rich receptor-like protein kinase PERK4
- Proline-rich receptor-like protein kinase PERK1
Sequence:
MESFAGSCEIVEEKDAVRLAKHSSRYCMSPLGSSKDMEQRPALKSGYQGSMEYDIDQLFQSITIKPSPRRVMGSSFHHLETSASAGTSRSTSPSNKGAMKKPFPMGTPRSPRVGPSDSISLKQALRDLCISKASEMASQKRLSKSAAASPRVSEADRIKTLYRQVLNESAGKPGLPVDKGKSLVEISLTPVVDIPSSSQSVPQRYDVLETEPSNFISEPSQAEILLHVLGNGSGIKTVGYGMLETVSLCKSNKSGSCLSSGSGDYEIEIDENHTSPPHMVIEDQLVEIDKHVTSLPSCSGSKVDTEELDKSIVSSARVKSEPTALSSGLKGKLDNFPGSGTEKSKLVSKVTRNIPRPKPRPKKKILLKKKLKIVVNSATKMVEEVDTSLEPSASQLLCQKCHCAVKSTSTENHPPSNTSHTTDKNVSIEADQESLASPRLIRIVKCNKEASKGSSDSCEVSDSGEAVIVMKQEVSPSNYSGKGDADEQIRANPTSSEKFDFSLSSKNSLGDYSSSTSMSEESNLSRFSCGNKPHMSMDVRWEAVKHVKLQYGSLGLRHFNLLKKLGCGDIGTVYLAELVGTNCLFAIKVMDNEFLARRKKTPRAQAERAILKMLDHPFLPTLYAQFTSDNLSCLVMEYCPGGDLHVLRQKQLSRCFSEPATRFYVAEILLALEYLHMLGVIYRDLKPENILVREDGHIMLTDFDLSLRCAVNPTLLRSTSPPEKDPARMSGPYSTSNCIQPLCIEPSCRVPCFSPRLLSTQARNQKPRKPKRPDLLTQQFRSLPQLVAEPTEARSNSFVGTHEYLAPEIIKGEGHGAAVDWWTFGVLLYELLYGKTPFKGYDNEETLSNVVYQNLKFPDSPLVSFQAKELIRRLLVKDPESRLGSEKGAAEIKRHPFFEGLNWALIRCAIPPELPDIYDNGATEATSPEGNNRYLECKAIGDHLEFELF
Protein: Invasin IpaA (70 kDa antigen) (P18010)
Organism: Shigella flexneri
Function: Rapidly associates with the first 265 amino acids of vinculin after bacteria-cell contact. This interaction is critical for efficient Shigella uptake. IpaA acts as a potent activator of vinculin and increase its ability to interact with F-actin. The complex IpaA-vinculin induces F-actin depolymerization along with the occasional formation of actin filament bundles.
Subcellular location: Secreted. Note=Secreted through the specialized type-III secretion system Mxi/Spa from the bacterium through the cell cytosol.
Interaction partners:
Sequence:
MHNVNNTQAPTFLYKATSPSSTEYSELKSKISDIHSSQTSLKTPASVSEKENFATSFNQKCLDFLFSSSGKEDVLRSIYSNSMNAYAKSEILEFSNVLYSLVHQNGLNFENEKGLQKIVAQYSELIIKDKLSQDSAFGPWSAKNKKLHQLRQNIEHRLALLAQQHTSGEALSLGQKLLNTEVSSFIKNNILAELKLSNETVSSLKLDDLVDAQAKLAFDSLRNQRKNTIDSKGFGIGKLSRDLNTVAVFPELLRKVLNDILEDIKDSHPIQDGLPTPPEDMPDGGPTPGANEKTSQPVIHYHINNDNRTYDNRVFDNRVYDNSYHENPENDAQSPTSQTNDLLSRNGNSLLNPQRALVQKVTSVLPHSISDTVQTFANNSALEKVFNHTPDNSDGIGSDLLTTSSQERSANNSLSRGHRPLNIQNSSTTPPLHPEGVTSSNDNSSDTTKSSASLSHRVASQINKFNSNTDSKVLQTDFLSRNGDTYLTRETIFEASKKVTNSLSNLISLIGTKSGTQERELQEKSKDITKSTTEHRINNKLKVTDANIRNYVTETNADTIDKNHAIYEKAKEVSSALSKVLSKIDDTSAELLTDDISDLKNNNDITAENNNIYKAAKDVTTSLSKVLKNINKD
Protein: Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3) (Q9NUV7)
Organism: Homo sapiens (Human)
Function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1-SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19416851}; Single-pass membrane protein {ECO:0000305|PubMed:19416851}.
Interaction partners:
- Serine palmitoyltransferase small subunit B
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase small subunit A
- ORM1-like protein 3
- 3-ketodihydrosphingosine reductase
- ORM1-like protein 1
- ORM1-like protein 2
- Serine palmitoyltransferase 2
- Alpha-1-acid glycoprotein 1
- Palmitoyltransferase ZDHHC9
Sequence:
MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPLHVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELED
Protein: E3 ubiquitin-protein ligase PPP1R11 (Protein phosphatase 1 regulatory subunit 11) (Q7JYN8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
KMAHKQSTNNETSNGSTTEIIDETDARAQLESGRTTPTLLLRLEHPRNERRVAFHAGIIDNEHLNRKKSKCCCIYKKPLAFGESSSEDDEDCEHCFGHPEKRQRNAKHNHNHGDKPCTEASHPEGPSTSTQAAHISQPPAEPVESKTDPKPPTPGVDFEQTGSS
Protein: Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein) (O54983)
Organism: Mus musculus (Mouse)
Function: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Trans-L-3-hydroxyproline dehydratase
- Cystathionine beta-synthase
Sequence:
MKRAPAFLSAEEVQDHLRSSSLLIPPLEAALANFSKGPDGGVMQPVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEGHSNTAVPSHQASVLLFDPSNGSLLAVMDGNVITAKRTAAVSAIATKLLKPPGSDVLCILGAGVQAYSHYEIFTEQFSFKEVRMWNRTRENAEKFASTVQGDVRVCSSVQEAVTGADVIITVTMATEPILFGEWVKPGAHINAVGASRPDWRELDDELMRQAVLYVDSREAALKESGDVLLSGADIFAELGEVISGAKPAHCEKTTVFKSLGMAVEDLVAAKLVYDSWSSGK
Protein: UL31 protein (Q77CC9)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MSDRGERRRAREPSPDFGCGRGAERAGDWATAPASTPAPAPGRRSLISPRLCSRSRSRSRSRSPFAPQGRSRSRGPATRRERLRSRTGARRAARARDSYLMYFRFLASSPADELAAVRELAVPLIRTTPVVLPFDLSRTVADNCLSLSGMGYYLGIGGCCPACTVTGEPRMGRADRALILAYVQQLSNIYEYRAFLASIRALGGTDDGGFGGCAPGPGGPTERALAEVLAQPELFFAYHVLRDGGVRDARVLFYRDLDCSGFMMYVVFPGKAIHLHHRLLDHLLTACAGYKIVAHVWQTMFVLVVRRDGGGGRQQSATDAEVPAVSAGDLYCKMSDLNFDGELLLEYRRLYAAFDDFAPPA
Protein: Transcription factor LBX1 (Ladybird homeobox protein homolog 1) (P52954)
Organism: Homo sapiens (Human)
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- F-box/WD repeat-containing protein 4
- DNA polymerase lambda
- Homeobox protein SIX4
- Homeobox protein SIX1
- Homeobox protein SEBOX
Sequence:
MTSKEDGKAAPGEERRRSPLDHLPPPANSNKPLTPFSIEDILNKPSVRRSYSLCGAAHLLAAADKHAQGGLPLAGRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPSGQMDIVALAELEQNSEATAGGGGGCGRAKSRPGSPVLPPGAPKAPGAGALQLSPASPLTDQPASSQDCSEDEEDEEIDVDD
Protein: Putative N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) (D2KKE6)
Organism: Komagataeibacter xylinus (Gluconacetobacter xylinus)
Interaction partners:
Sequence:
MARIWKGPFISPHRLGAQPAHALPPVPARVSAVIRTGAVKLVTLAPEVEHADTAIQQFVNAGIRVSIGHTQADHEQTDRAICRICGGGGVAGGTHMFNAMPPVMARAPGPATALMCSDDAYAEMIFDTHHVHPALFRLAHRVMGRLLFVTDAM
Protein: Tubby-like F-box protein 5 (AtTLP5) (Q944S3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable E3 ubiquitin-protein ligase ARI2
- Ankyrin repeat family protein
- LIM domain-containing protein WLIM2b
- Large ribosomal subunit protein uL10c
- Protein CLT2, chloroplastic
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Sequence:
MSFLSIVRDVRDTVGSFSRRSFDVRVSNGTTHQRSKSHGVEAHIEDLIVIKNTRWANLPAALLRDVMKKLDESESTWPARKQVVACAGVCKTWRLMCKDIVKSPEFSGKLTFPVSLKQPGPRDGIIQCYIKRDKSNMTYHLYLSLSPAILVESGKFLLSAKRSRRATYTEYVISMDADNISRSSSTYIGKLKSNFLGTKFIVYDTAPAYNSSQILSPPNRSRSFNSKKVSPKVPSGSYNIAQVTYELNLLGTRGPRRMNCIMHSIPSLALEPGGTVPSQPEFLQRSLDESFRSIGSSKIVNHSGDFTRPKEEEGKVRPLVLKTKPPRWLQPLRCWCLNFKGRVTVASVKNFQLMSAATVQPGSGSDGGALATRPSLSPQQPEQSNHDKIILHFGKVGKDMFTMDYRYPLSAFQAFAISLSTFDTKLACE
Protein: Large-conductance mechanosensitive channel (P68806)
Organism: Staphylococcus aureus (strain MW2)
Function: Channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 3 nanosiemens. May participate in the regulation of osmotic pressure changes within the cell.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00115, ECO:0000305|PubMed:19701184}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00115, ECO:0000305|PubMed:19701184}.
Interaction partners:
Sequence:
MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFALFIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREKK
Protein: Retinoic acid-induced protein 2 (Q9Y5P3)
Organism: Homo sapiens (Human)
Interaction partners:
- Actin remodeling regulator NHS
- Ubiquitin-like protein FUBI
- Cyclin-dependent kinase-like 5
Sequence:
MDDLQSQNLSMDMTDSPPALANNRLENGMAQLITTEAWNINSTDLVKKALVTVPAPSILNPPAESQSGMALKVAATVLQPLCLGESPVVMPIHMQVEGSSAPELNPNGNATYVMTTQGPVQLPVVLEQHVFQHLNSPLVLPQEAPCSSSTIHNNLFQGAEDPEAQPQLLDLRIPSQPQEPTLPFEAVLQNLFPSQGTLGPPPCQPPPGYAPVPPQPFSSPLSPLVPPATLLVPYPVIVPLPVPVPIPIPIPMPQSSESKFSSSFPKPPSSFGLHPFKGTQTPLEKDELKPFDILQPKEYFQLSRHTVIKMGSENEALDLSMKSVPWLKAGEVSPPIFQEDAALDLSVAAHRKSEPPPETLYDSGASVDSSGHTVMEKLPSGMEISFAPATSHEAPAMMDSHISSSDAATEMLSQPNHPSGEVKAENNIEMVGESQAAKVIVSVEDAVPTIFCGKIKGLSGVSTKNFSFKREDSVLQGYDINSQGEESMGNAEPLRKPIKNRSIKLKKVNSQEIHMLPIKKQRLATFFPRK
Protein: Retinoic acid receptor responder protein 2 (Chemerin) (Q9DD06)
Organism: Mus musculus (Mouse)
Function: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin.
Subcellular location: Secreted {ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:18242188}.
Interaction partners:
- Chemerin-like receptor 1
- Chemerin-like receptor 2
- C-C chemokine receptor-like 2
- Leukotriene B4 receptor 1
- Serpin A12
- Nicotinamide phosphoribosyltransferase
- Adiponectin
- Resistin
- Resistin-like gamma
Sequence:
MKCLLISLALWLGTVGTRGTEPELSETQRRSLQVALEEFHKHPPVQLAFQEIGVDRAEEVLFSAGTFVRLEFKLQQTNCPKKDWKKPECTIKPNGRRRKCLACIKMDPKGKILGRIVHCPILKQGPQDPQELQCIKIAQAGEDPHGYFLPGQFAFSRALRTK
Protein: Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1) (P09466)
Organism: Homo sapiens (Human)
Function: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa.
Subcellular location: Secreted {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:3667877}.
Interaction partners:
- Growth/differentiation factor 5
- Growth/differentiation factor 7
- Bone morphogenetic protein receptor type-1B
- Protein AMBP
- Lipocalin-1
- Growth/differentiation factor 6
- Growth/differentiation factor 2
- GRAM domain-containing protein 2B
- Bone morphogenetic protein receptor type-2
- Complement component C8 gamma chain
Sequence:
MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVHITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF
Protein: Auxin-responsive protein IAA11 (Indoleacetic acid-induced protein 11) (Q38829)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Auxin response factor 7
- Protein TOPLESS
- Auxin response factor 5
- Auxin response factor 19
- Auxin response factor 9
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA16
- Auxin transporter protein 1
- Auxin response factor 18
Sequence:
MEGGSASGSASALSNDENLVVSCEDSSSPIGNELELGLTLSLGRKGYRDCRVYADDSSSSSSSSSLSRASVIAGIKRTADSMAATSGQVVGWPPIRTYRMNSMVNQAKASATEDPNLEISQAVNKNRSDSTKMRNSMFVKVTMDGIPIGRKIDLNAHKCYESLSNTLEEMFLKPKLGSRTLETDGHMETPVKILPDGSSGLVLTYEDKEGDWMLVGDVPWGMFIGSVRRLRIMKTSEATGKAQMIL
Protein: Thromboxane A2 receptor (Prostanoid TP receptor) (D0EXE4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein
Sequence:
MDIFFTPSFPVLCQDSRGHNYTIPCADNQTLNSTSPSTVNPPAFGMSYFTMTLGALSNLTALAILAHSYASFRRRAKVPFLLLASTLLLSDLAGHLITGALALNLHLERVKHHGQMEVEPPRIYCKLFGACMVFFGLCPLLLGSAMAVERCIGITQPLLHSTVVTMTRVRFSVLLITSMALTLAGLPLLNVGNYKPQFPGTWCFLPVNGPLSIADVSLTLAFSILGLLTLIVSLVSNTLSGLKLLQARIKDGCLKSSAARRHGSFSSSSLHSLDVEMMTQLAVITVVSCVCWSPFLIYILMSVSRFYEGVSRPKHQCEKLFLLALRLASWNQILDPWVYILLRRAVLRRVLQLLQPDRAVYTQSSSYRDSHRKTIS
Protein: Tetratricopeptide repeat protein 14 (TPR repeat protein 14) (Q9CSP9)
Organism: Mus musculus (Mouse)
Interaction partners:
- Arginine/serine-rich protein PNISR
Sequence:
MDRDLLRQSLGCHGPALLSLLRSEQQDNPHFRSLLGTAAEPARGAAPPPGAGRKEKRVDNIEIQKFISKKADLLFALSWKSDASPPSEVHDDNDNLYAVMPPLEQFMEMPSMDRRELFFRDIERGDIVIGRISSIREFGFFMVLICLGSGIVRDISHLEITALCPLRDVPSHSNHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYSSSLPPHMAGIKLGVITSEELPMYYRRSVELNSNSLESYENIMQSSLGFVNPGVVEFLLEKLGIDESHPPSLMRGLQSKNFSEDDFASALRKKQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELREKQAEKEEKQKTKKIETRAEKLRKLLKEEKRLKKKRRKSSSSSSVSSADESVSSSSSSSSSSHKRHKKSKRNRSESSRSSKRHWSRPSSGHTDQSRKDDCYPVPTNTSASFLNQKQEVEKLLEKQDRLQCPNAQVKEKERGLLTSSGEVPDDLGGRSDFYNSYKTQAGSSKTEKPYKSERHFSRRNSSDSFSRNSEDKMKASSYRRFEKDTEGRKDHSRRWEPSSVKYSTSPASSDYSWKSLEKQKKYTYSGSRDVSKHEQRYQLNTNQGERVYEKEDSCGEGNRNEAPEEMLNSKEQPDSRVKKNLPQNLLNIFNQIAEFEKEKGNKPKK
Protein: Nuclear pore complex-interacting protein family member B5 (A8MRT5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTALPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRMISRHLPSVSSLPFHPQLHPQQMIISRYLLSVCGFRFHHQPMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPERMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS
Protein: MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) (Q9WVG9)
Organism: Mus musculus (Mouse)
Function: Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8N5Y2}.
Interaction partners:
- Male-specific lethal 1 homolog
- E3 ubiquitin-protein ligase MSL2
- Histone acetyltransferase KAT8
- MRG/MORF4L-binding protein
- Histone acetyltransferase KAT5
- Transformation/transcription domain-associated protein
- Chromatin modification-related protein MEAF6
- DNA methyltransferase 1-associated protein 1
- KAT8 regulatory NSL complex subunit 3
- KAT8 regulatory NSL complex subunit 2
Sequence:
MSASEGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNRSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKKKVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY
Protein: Coiled-coil domain-containing protein 39 (Q57Y17)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLEVVDATAEALPLELLNAVNKELTAQLSRHEEIHDGHVREIQDQRRRLEFVKEHLANVRGEIVNTQALADSKRREMESESHMYRLLLRECGRLKQSQMQMQAEQADVQERLQVVQDRLFTENLRMAELKSSMAYNQEALEQWDAARQQKESDEAAVARYAKDDAVKLRQLDIAVERHEAQLRERRRQLQDEVAVMRSVQLELNRVATDYRRQHKERGDLIDEWERVVKEIRERDNSIRAAAQQYAEGAEWIEQRRVALKKLHDDYDAARAEEALMQAGIEEREHRAEKSRQTRSSLETHVTGLENEVETIREELGRSIKERNNARIRLEQSKVAVRDKTAAHERLTAKRDDLKEQKSSVYSKGADLSTQLATIGRLFKEAQDAEKQMDKETEMLKKENFTMSERLKEVRREQSDLLAEISGGQLQAQNLRTKIGQLDGQYFAQQQLLYAVEFSVQQMQRKVNRAKGERSLDERNKLQEKIATLQNTLADLMKQQRAMEIQVKRVREETWHANVELERVTSEKKIAAEKLLQLTLGCDSCTAELTKLRKQHEEKLVLVDTQELQLQDLKRTLHQRNGELGSLAERKRQLTCDIAERLSEIAVHHDMMKMEAKLVEEQRRRLASDLRERQKSLAGLRNRYDVQLVRLDPEKVNWTPAQVVMEAAREREDLQLRGDTLDVRVSRMEREMDKLKRTLSVIRASNSNYRHMFDPVPESHDMVKMRIALQQQQRDLKAAVSRRVMELNDYQQVMESKEQDLRQIIEKRERVRATMENLQKACEQVHEGIMQARETVIRYTQTIQKASANVPPEVLADVELQEKRDMFNSALGRLLQLAQQHGDEVRHHVQTLLASRLVIE
Protein: Guide RNA binding protein (Q57ZX7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mitochondrial RNA binding protein
- Uncharacterized protein
- HTH OST-type domain-containing protein
- Treble clef zinc finger domain-containing protein
Sequence:
MRSALRRCILRHQGCLRMKQSLSAFPTVVTGMTRHQGNSLIGTTHGAELSLAGDPQSVSHLSARNIATEALQMKKLHQERGGNPMLAQQARRVLFATSIAGQNLDARSVALLLNTAVYFGMESDAKLVRECIDYCLKNDKLITVDVLPIVVTACATLKSRDAREVIEMQAQKAARNAKFLDAKDVTNIISAFSKTGINHEKLFAFLSRRVQTLARVGEFEAAHLVILANAFSRLRYRDKFLFGAIARRAMSLRERVTVNELVPLIVAFSKIGLKDPKLSKRFATKAMEYVDQMNAEQVASMFMAFAYFGIRYDQLFGVLTNRAVELIDEFNAQYISTTLNAFQRIGINNPELFDNLAERALAVVQDHDARDISKTVTALAHFGLKDEELFKRLASHAASIADQFDAMGLVNTAHAFARTNFLQQDMAVALSERSVYVCRLLDAGETRRLLWALAKFQVRDPKILTPVFNRCLALHYDFFADPTGSEEIEEIFDFYGPNFCPPLYQLYISRGSTPQA
Protein: PR/SET domain 8 (E9PEH0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEDTGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRSHNKMNGSSPYTCLECSQRFQFEFPYVAHLRFRCPKRLHSADISPQDEQGGGVGTKDHGGGGGGGKDQQQQQQEAPLGPGPKFCKAGPLHHYPSPSPESSNPSAAAGGSSAKPSTDFHNLARELENSRGGSSCSPAQSLSSGSGSGGGGGHQEAELSPDGIATGGGKGKRKFPEEAAEGGGGAGLVGGRGRFVERPLPASKEDLVCTPQQYRASGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAARAASLQEEGTADGAGVASEDQDAGGGGGSSTPAA
Protein: 33-36 kDa outer membrane protein (Q5K1Z4)
Organism: Acinetobacter baumannii
Interaction partners:
Sequence:
MKKLGLATAVLLAMTGAHAYQFEVQGQSEYVDTTANDKNFTGTAQGTYYFKNVDASKGPLAEAAFLNQASNVSVAYNYIKYDEKDTVNVESHTYGVKGEAYLPTPYLPVYASASYNHTINDFKDGVSDDNGDRYALEAGAMLLPNFLVAVGYTSVADQVSLDAFGVNKYGIAKAVGESVAIDEKQDAVTARTKYVGNIDGTNMAIGFEAFGVFAEDNAYGMKTDLFVTPKLSVGASFADVSAFNSGYDHVWGGHTQYFITPAVAVGADFVKANAKDGNPRDTQTIGLNAKFRF
Protein: C2 domain-containing protein (Q38B77)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTGGNSGISATGAGSVVLLPRGVYATVFEPINSAEEQQKVALEDSVRRPLDDHQKANISSMAGAAGRFEAQRRLRKAMAAKEATMIQLKQLIREYSSPGEGPNRSKEQLKMVNDKVTGCSLGEINGIPSPAVALGHIEKDISVHPAADLACDAEVLRLKLENEKLSVKETALKREREQLERLVVDLRKELEASGDALRDQTELLQTIRISEGRHGSHVFFKHKPEKLSEPITTAAPSEERKKGGEKDDENEKGNKEEDKKEEKKKDTICEGDKVSDMLKRIEALEGLLALEEKRREAVEKRCEELLAMSSERKAGDEPTPLAARTADWGTVAGRREEEGGKTLKTDPACKENLFEPAPAVEDSPGKSAKDGRDTNLNRVIRVLVEKHRAARVVWTRREKEFKRYTQVLESVMTRMERGLPAEEPGKAALFNLTVSLVACENLLNRRNNGALFIDPFVVLYSPIGEKALETLPREDTNCPQFTNAGDTVTFKVVRGLPWSLTFEVYSRGVNNTGLFLGQAKVPVESFLEDVAVDKRFQRKVRLCPRDREPDSEVIQNAHRLGSIIFTACISVVGRDRRSSSIPAVSPRNSAITSSGCRRSVLDVKRSMEAEHYDTVNVDVSCSAGEEARCCSPADAVILRVLSAKGVIKRPSGVYSNPYVVAFDSGTGEELLHTPPVMASSNPQWEHSAQGRCIIRPDHARGSVTFRVYDHDQEGKDRFLGEAHLPKRLIFSGKELHELKLEPRRDESLEYIRRKQHKLGKLVVQCVRKNARSEGERSRTQSGGSVCRSAPYPGAVCGFTESSKILHEDSVTNCKTILLDALPIRVTVEACNGLCIDRSGGYVVVCIVSPNLVEYMTSAVCGTADPSWTGTDNSATFSVHPLSSGAIQFHVMAQDRKCGYGGRIVGCAQISTLDLFRRGFGRKKLQLGGPPDRADILRRQRQSGQGTITVFFSLLSSPPVRGEDEVTCSQEKRAAAVSPAAVTNGQSEPSLTRRQDRNTPASTGVAMSIYIKEAHDLLDYDKSMFNVLGVTDPRVTVWVGPNHAFTTPEKRDTVNPKWSLEEAEFQVSVERGHVIRFEVQDVDTTGFDSLGSAVVDASEVIESPGARTLPVMLREKQYGTLTVVFTLVDKKDSTKE