wanglab/gogpt-training-data huggingface dataset:
Protein: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) (A0A140VKB3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVVAAAAGWLLRLRAAGAEGHWRRLPGAGLARGFLHPAATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDVAFGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPYNIPLSQAEVIQEGSDVTLVAWGTQVHVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASEISSTVQEECFLNLEAPISRVCGYDTPFPHIFEPFYIPDKWKCYDALRKMINY
Protein: UDP-glucose 4-epimerase, putative (EC 5.1.3.2) (Q4WX18)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- UDP-glucose 6-dehydrogenase
- UDP-glucose 6-dehydrogenase
- UDP-glucose 4-epimerase
- UDP-glucose 4-epimerase
- Galactokinase
- Glycosyl transferase, putative
Sequence:
MDSYQQSDASTPVEPCSPGCVDTPATQSSVLFDGHLDDLLRHFPLDQYILVTGGLGFIGSHTTLELLKANYNVIVIDNLSNSFQIVFDRIKLLASQYHERQGTKMPSLHLHAHDYRDTAALKELLEQHQTQTRWGTTKSKISGVIHFAAYKAVEESIRNPLKYYANNVSGLIDFATTLGDYGIKTFIFSSSATVYGTLATSGLPLKEELCTHKEEIYTDHDGSERIVQPGCTGITNPYGRTKWICEAILADLAASDPEWTIVALRYFNPIGCDESGLLGEDPRQTPTNLLPVVVKVMTGEYRELQMFGTDWNTEDGTAVRDFIHVTDLARGHIAALSAANEGKLAENFRTFNLGTGRGHSVKEVVETMEEVSSKHIPRRAADRRAGDVGSCVAVATRSQQELNWKTEKSLKDACVSLCNFLEVSGLST
Protein: Protein O-glucosyltransferase 2 (EC 2.4.1.-) (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58) (KDEL motif-containing protein 1) (Protein O-xylosyltransferase POGLUT2) (EC 2.4.2.-) (Q6UW63)
Organism: Homo sapiens (Human)
Function: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Filamin-A
Sequence:
MFGTLLLYCFFLATVPALAETGGERQLSPEKSEIWGPGLKADVVLPARYFYIQAVDTSGNKFTSSPGEKVFQVKVSAPEEQFTRVGVQVLDRKDGSFIVRYRMYASYKNLKVEIKFQGQHVAKSPYILKGPVYHENCDCPLQDSAAWLREMNCPETIAQIQRDLAHFPAVDPEKIAVEIPKRFGQRQSLCHYTLKDNKVYIKTHGEHVGFRIFMDAILLSLTRKVKMPDVELFVNLGDWPLEKKKSNSNIHPIFSWCGSTDSKDIVMPTYDLTDSVLETMGRVSLDMMSVQANTGPPWESKNSTAVWRGRDSRKERLELVKLSRKHPELIDAAFTNFFFFKHDENLYGPIVKHISFFDFFKHKYQINIDGTVAAYRLPYLLVGDSVVLKQDSIYYEHFYNELQPWKHYIPVKSNLSDLLEKLKWAKDHDEEAKKIAKAGQEFARNNLMGDDIFCYYFKLFQEYANLQVSEPQIREGMKRVEPQTEDDLFPCTCHRKKTKDEL
Protein: SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap) (Q9C0H9)
Organism: Homo sapiens (Human)
Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9QXY2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXY2}. Presynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynaptic density {ECO:0000250|UniProtKB:Q9QXY2}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250|UniProtKB:Q9QXY2}.
Interaction partners:
- Microtubule-associated protein RP/EB family member 3
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- Tyrosine-protein kinase CSK
- Proto-oncogene tyrosine-protein kinase Src
- Synaptosomal-associated protein 25
- Disks large homolog 4
Sequence:
MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
Protein: Uncharacterized protein Rv0891c (P9WMV1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv0894
- Putative HTH-type transcriptional regulator Rv0890c
- Uncharacterized protein Rv1359
Sequence:
MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGSLDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS
Protein: Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) (O94677)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes at the barrier septum.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 1
- Vacuolar protein sorting-associated protein 53
- Protein transport protein gos1
- Vacuolar protein sorting-associated protein 54
- t-SNARE affecting a late Golgi compartment protein 2
Sequence:
MDVKSKHGHIKSNPEESLLFRNSVSKNIAQLSSINYADRNVQAALEQLSERKFKNEREARKQLPFEVFSDLIWTNGSIIKELSELSSQTLSVQSQLLKVKNSIDSYKNEWSKKTNDAQILLNSYETFCEEEALIEEKLKNIEIFEKNFVIMDDDLIHLTSSTDVDDRFYLILDKAQEIHDSSDSLFASLSGFVEYSSFEEIVKKMSRYIEAAFEKLFRCVQTELSDPQTAQTLEANSHLKKAFTKLFSEPTMVNKSINLIVQARQQILSTAYLTALTRGDFLSSSRPIELSAPDTVRFIGDLLAWIHQTIVNEKELVEALFAARKRQIQLNPFPPWDVPNVLEDQMNSLLDGSLYGICRPLSSRAQTSVLDLSDIVRLYNVIEILGFYREAFSKIVHDECIILRIIKTLEDFTYQRMKTVLDDELYTISNTNLSITDDLLPPDFVTTFLRNANSIFKIRGASLSVQGVDELPFKMLFMQLFDRILEICAAMTEDVRPPYKGIILMLNVLDSCTNYVGRYTFLNELFEYLQEKTTYYKNNLTTLLNNDYIAQAGLSDLLQKIADTTDDKQALKNYLHSWKWDQQIDKFSTFIRKTLSETIDNLQLLTSPIVTNQVLKETAISFVGAIETVDKALELSNLERRWPLSTEELLIAMNVDSMDTLSDIGQSDIDNLSVN
Protein: RBR-type E3 ubiquitin transferase (EC 2.3.2.31) (Q20871)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein kinase domain-containing protein
- Nucleoporin_N domain-containing protein
Sequence:
MTDRDLQIYELEALESVLREKKLAKSSDWSDKNAEIQGIIEVGFDNLYDPTVTIEGTSDSGDQFHLPLDILPPIRLKFHLPNDYPTVSSPKLELESYWMNQEQMTSCETELAKICEENQMMEVLFMCYQTIIDLMAQNTPKIINLNEACALNRQGETIESLKMKILQKEEEAVEEQFVNTLYDCQVCFESQMGQHCIKFQPCSHVFCKSCTFNYYISIAKGFVSKPMSCLAEGCENEAQQGMVQEALGEELFAKYEAHMLEKAIREMDDSMECPNENCQMVAYLTDSQRNLVECSYCNYSFCNLCKGTFHGVSRCKFRKEDEERIMKEWNEADEAGKEEMYKRYGEKNMKALEERFLNRGWLEENSKQCPKCLVYIEKDEGCNKMHCTKCNASFCWLCSKTLNNVDPYSHYSEKGSCNGRLFQGTWVDEEVDEFDWE
Protein: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Q98TY6)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MSAPLKKGPGGLIGLMKDAFQPHHHHLGPHQPGAVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILRTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGGGGLSRQGAEGTPSPNYDDDDDDRADDSLFMMKELAGTKVERPPSPFSVAPQATLPPVPPRLDLLQQRVSNPPGASSPSTSSKAAPGTLHKDKPLPIPPTLRDLPPPPPPDRPHSIGADARPQRRPLPCTPTDCPARDKPPPVPSNRQGDLWPSRPIPKAPSVAHSPGDHWPGRELSNRHSLPFSLPSQMDSRPESHRLGSTLSLDNPVNLNTGPPATSECEHPKIKPSSSANAIYSLAARPLPVPKLPPGEQSESDEDTEYMSPSSLPVVPPGPAVQKPEIKMPLEMTQSLRVLECDRQADGCMYEAMYNIHSQAMPSAFETVNTSDEGDLAAATASNGPEESENEEDGYDVPKPPLPVAIARCTLSDISNATPAFSRMSLENDPVTGFSDGSQVPERPPKPLPRRINSERKAGSCQPGAASSNTGASLQLSSEIENLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT
Protein: Ubiquitin receptor RAD23 (DNA repair protein RAD23) (F4IF85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367049}. Cytoplasm {ECO:0000256|RuleBase:RU367049}.
Interaction partners:
Sequence:
MKLTVKTLKGSHFEIRVLPSDTIMAVKKNIEDSQGKDNYPCGQQLLIHNGKVLKDETSLVENKVTEEGFLVVMLSKSKSGGSAGQASVQTSSVSQPVSATTSSTKPAAPSTTQSSPVPASPIPAQEQPAVYAFVFSFAGLAFCPLYGFPKVSMAQTDTYGQAASTLVSGSSLEQMVQQIMEMGGGSWDKETVTRALRAAYNNPERAVDYLYSGIPQTAEVAVPVPEAQIAGSGAAPVAPASGGPNSSPLDLFPQETVAAAGSGDLGTLEFLRNNDQFQQLRTMVHSNPQILQPMLQELGKQNPQLLRLIQENQAEFLQLVNEPYEGSDGEGDMFDQPEQEMPHAINVTPAEQEAIQRLEAMGFDRALVIEAFLACDRNEELAANYLLENSGDFED
Protein: LRRCT domain-containing protein (Q22075)
Organism: Caenorhabditis elegans
Interaction partners:
- Menorin
- Clc-like protein
- Neuroglian
- Leukocyte cell-derived chemotaxin-2 homolog
- DH domain-containing protein
- Actin-4
- Furin-like protease kpc-1
- Receptor-type tyrosine-protein phosphatase
- Netrin unc-6
- Latrophilin-like protein 1
Sequence:
MISYILLLFLSFLVLCSIALPSSCPNLCECDQNDSSWSVYCRKAIINDTIYAEILNQLPLTLRSLHIQPPSNRIGSNKLRWNDNINRFAQLRVLRLINCQIPAMSRSIRLPSLEVLDLHSNNIEHATMSNFGGMPKLRVLDLSSNHLNILPTGVFTYLRALRSLSLSNNTISDLSTNLLRGLNSLRVLRLDRNPIPIEHINELFTDVSQLDELYLNHCNLSSIYSLALDRIPQLRQLGIGGNNLKMVPTKELRSLPQLSVLDLSHNSIQEITACAFCNTNISKLDLSHNLLGISKDSPFNEDAFRTMPLRHLDLSFNHMNDFDSKWLGWAQEELTSIALSGNFLKNFEESWTYTLKSLIHLELAYNHIKFIPVQLPSRYYHLISLNISGNELTYLPDNINTLLPNVKTFDITANRFHTFSHTDLAFLNNVEQVYVDGNPWDCSCAIQGLQVHMRDRYAMRHILNYDNVRCATPSLVEGHSVLAITDVNDCAVLFGARYGLTQTSEMLILLAGVLLFAALLLMILGCIYFLRERQYKGSYVTREHSRTPLTMANTHSCSSSTNDTHGPLSPPFDPFLVSTETFKATPPLIPPAPPKPGSSYFGI
Protein: FTH domain-containing protein (G5ECG9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSLSKFLMKRLKNSPIVEIDTKEDADQVSVEFLLFSTTKLSPIKVIYKNHPEGCQRVHDGQEEFIKNKNYIELCSDDLESVLSSMRVLSHLSITISEESSLNKTDVTFLKHLKRILDLRPSSLIVNDFTLTLRSISSMPNALSVVVSCRSDIFKTLKLNAMNDHDKCVFEKTLPIDNSLQNVYADDQLVMLENLVNGELHDFYGTTKLFTYILAFSDEYPIDKSLIQESFEVTGKCCQSSNLGADQVTVKNTFSSNTTLSDFPTRHSESL
Protein: Protein E7 (Q07857)
Organism: Human papillomavirus 4
Function: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004}. Note=Predominantly found in the host nucleus. {ECO:0000255|HAMAP-Rule:MF_04004}.
Interaction partners:
Sequence:
MRGAAPTVADLNLELNDLVLPANLLSEEVLQSSDDEYEITEEESVVPFRIDTCCYRCEVAVRITLYAAELGLRTLEQLLVEGKLTFCCTACARSLNRNGR
Protein: Photosystem II reaction center protein Z (PSII-Z) (P0C429)
Organism: Oryza sativa (Rice)
Function: Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00644}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00644}.
Interaction partners:
Sequence:
MTIAFQLAVFALIVTSSVLVISVPLVFASPDGWSNNKNVVFSGTSLWIGLVFLVAILNSLIS
Protein: DUF1993 domain-containing protein (Q5AZ57)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MSTIHTYAITPFIQGLKALTAILKKGEEHAKANNIPLEDLVNASLIADMKPLSFQVFIATNTAVKLVSRATFVEPPAQSDTDKTFDDFYKRIDEALAVLEKADAQTIAANEGKTFKAPLGPREFEFTPESYTNSYAVPNFYFHLVTAYDILRAKGVPVGKMDYLKDFLGDIAA
Protein: RacA (Small GTPase) (A0JC80)
Organism: Epichloe festucae
Interaction partners:
Sequence:
MAQPGVQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWYPEIDHHAPNIPIILVGTKLDLREDAATLDSLRQKRMEPVSYEQALACAREIKAYKYLECSALTQRNLKSVFDEAIRAVLNPRPQPSKHKKSKCSIL
Protein: Isochorismatase domain-containing protein 2 (Q96AB3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17658461}. Nucleus {ECO:0000269|PubMed:17658461}. Note=Localizes to the nucleus in the presence of CDKN2A.
Interaction partners:
- Cyclin-dependent kinase inhibitor 2A
- 5-oxoprolinase
- Nicotinate phosphoribosyltransferase
- Maestro heat-like repeat-containing protein family member 6
Sequence:
MAAARPSLGRVLPGSSVLFLCDMQEKFRHNIAYFPQIVSVAARMLKVARLLEVPVMLTEQYPQGLGPTVPELGTEGLRPLAKTCFSMVPALQQELDSRPQLRSVLLCGIEAQACILNTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSEGLILQLVGDAVHPQFKEIQKLIKEPAPDSGLLGLFQGQNSLLH
Protein: Cell shape-determining protein MreC (Cell shape protein MreC) (Rod shape-determining protein MreC) (P84480)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Involved in formation and maintenance of cell shape. Regulates protease expression and stimulates the neutral protease production in Bacilli together with MreD.
Interaction partners:
Sequence:
MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVFQNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDELGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKSSGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDKQDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVVNRDVPTVDTEEEGS
Protein: LOC100037036 protein (A1L3K9)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
KEIRRTSCNNHMERRQRQARDISAPYRSVCPYSSTMERGDRQTRKPLVEKRRRARINESLQELRGILSDNEFQTKIENAEVLDLTVKRVERILRNRTAEADRLQREASERFAAGYIQCMHEVHTFVSSCPGIDASLAAELLNHLLESMPLSEGSLQDLVMDVLLDSPSSEEGCGLGVLGSSSEDSCSDMEESEGEKAGIDSVQDNGRTPEIQPPASTMWRPW
Protein: Putative voltage-gated potassium channel subunit beta (EC 1.1.1.-) (K(+) channel subunit beta) (O59826)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MASATTHFQPKNVPFRFLGRSGLKVSAFSLGGWLTYGNEGYDVEHTKNCLKQAWDLGINTFDTAEIYSNGNSETVMGKAIKELGWDRSEYVITTKVFFGAGTKLPNTTGLSRKHIIEGLNASLKRLGLPYVDVIMAHRPDPSVPMEEVVRAFTQLIQDGKAFYWGTSEWSAFEIEHAHHIATKYNLIAPVADQPQYNYLTRDHFEKDLLPLQQIYGYGATVWSPLKSGILTGKYNDGIPEGSRLSTTFTSLAGQLQTPEGKTQLDQVRQISKIAEQIGATPSQLALAWTLKNPYVSTTILGASKPEQIVENVKAVEFIDKLTPEILKKIDEILNFTPLEIQYRR
Protein: Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) (Q7TQM4)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O88908}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Delta
- 7-dehydrocholesterol reductase
- Sterol O-acyltransferase 1
- Cytochrome P450 7A1
- Cholesterol 25-hydroxylase
- Sterol 26-hydroxylase, mitochondrial
- Cholesterol 24-hydroxylase
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Steryl-sulfatase
- Sulfotransferase 2B1
Sequence:
MEPKAPQLRRRERQGEEQENGACGEGNTRTHRAPDLVQWTRHMEAVKTQCLEQAQRELAELMDRAIWEAVQAYPKQDRPLPSTASDSTRKTQELHPGKRKVFITRKSLLDELMGVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMMWVPMFLSTLLLPYQTLRLWARPRSGGAWTLGASLGCVLLAAHAAVLCVLPVHVSVKHELPPASRCVLVFEQVRFLMKSYSFLRETVPGIFCVRGGKGICTPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQALGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRQGRGAAMLGVFLVSALVHEYIFCFVLGFFYPVMLILFLVVGGLLNFTMNDRHTGPAWNILMWTFLFLGQGIQVSLYCQEWYARRHCPLPQPTFWELVTPRSWSCHP
Protein: AT-rich interactive domain-containing protein 5 (ARID domain-containing protein 5) (Q0WNR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
Interaction partners:
- Homeobox-DDT domain protein RLT1
- AT-hook motif nuclear-localized protein 1
- Probable E3 ubiquitin-protein ligase RHC1A
- At1g43860
- C2H2-like zinc finger protein
- T-box transcription factor, putative
- B3 domain-containing protein REM16
- ISWI chromatin-remodeling complex ATPase CHR17
Sequence:
MMADTEMQEQDVPSGTKGVVEEPSELEKDLNSIERPKSPVPEDTTHTLDSDVHLSDAPIANQIEANEEVGGQNSVDGRNGDVDQSEKKITSDGGQEETTLGESNPLKGDPSSPHVPEESVKKWKTWLLSDAEAREVDEAGAPQDQEAFIKEVEAFNKENFLEFKAPKFYGQPLNCLKLWRAVIKLGGYDVVTTSKLWRQVGESFHPPKTCTTVSWTFRIFYEKALLEYEKHLRQNGELNLPGSASLPSSGIEKEASSHQASGSGRTRRDAAARAMQGWHSQRLLGSGEVTEPIVKEKGLNSTPKQKNLKNIGVQKQKTTTGMDLVFSHESEKQSTAEVIDVGPPADWVKINVRETKDCFEIFALVPGLLREEVRVQSDPAGRLVIAGQPEQLDNPWGITPFKKVVNFPARIDPLHTSAVVSLHGRLFVRVPFEQ
Protein: GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) (Q921J2)
Organism: Mus musculus (Mouse)
Function: Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:16631613}; Lipid-anchor {ECO:0000269|PubMed:16631613}; Cytoplasmic side {ECO:0000269|PubMed:16631613}. Lysosome membrane {ECO:0000269|PubMed:16631613}; Lipid-anchor {ECO:0000269|PubMed:16631613}; Cytoplasmic side {ECO:0000269|PubMed:16631613}. Golgi apparatus membrane {ECO:0000269|PubMed:16631613}; Lipid-anchor {ECO:0000269|PubMed:16631613}; Cytoplasmic side {ECO:0000269|PubMed:16631613}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15382}; Lipid-anchor {ECO:0000250|UniProtKB:Q15382}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15382}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15382}. Note=Farnesylation is required for localization to endomembrane system. {ECO:0000269|PubMed:16631613}.
Interaction partners:
- Regulatory-associated protein of mTOR
- Serine/threonine-protein kinase mTOR
- Tuberin
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
- Proline-rich AKT1 substrate 1
- Hamartin
- Target of rapamycin complex subunit LST8
- DEP domain-containing mTOR-interacting protein
- TBC1 domain family member 7
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEKIDGAASQGKSSCSVM
Protein: Inner membrane protein YgfX (Toxin CptA) (Q46824)
Organism: Escherichia coli (strain K12)
Function: A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression. Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP-dependent polymerization. Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:22239607}; Multi-pass membrane protein {ECO:0000269|PubMed:22239607}.
Interaction partners:
- FAD assembly factor SdhE
- Cytoskeleton bundling-enhancing antitoxin CbeA
- Cytoskeleton-binding toxin CbtA
Sequence:
MVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQEWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Protein: E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) (Q8C7M3)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q91ZY8}. Synapse {ECO:0000250|UniProtKB:Q91ZY8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZY8}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). {ECO:0000250|UniProtKB:Q91ZY8, ECO:0000269|PubMed:20085810}.
Interaction partners:
- Netrin receptor DCC
- Vasodilator-stimulated phosphoprotein
- F-box/WD repeat-containing protein 1A
- Synaptosomal-associated protein 25
Sequence:
MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP