wanglab/gogpt-training-data huggingface dataset:
Protein: KEK1 (P91643)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHIREAVFLVLTLLPGMILGTRYNQLHLYANGGASSSGPGGYRPAPSSQNEVYSIADSQPMTEDGYMPPSQHFPPTHSDLDPPAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNGSIGGVVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGYDNNGSVLSTASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPPISGVGVGGSGEYSRANGCDSLYPSGLWEHGAPVGTTSADDLFMKRYTDKTPIIDSTQLYDLHERTAATDYFSKTFPRSHLQQGMMTGGGGGTSTASTVTTNLSGGSSSGYPNDYGLPLVPGAEHQHNHQLQMHPLQQLQQQLTSTLNHQKQEGSSTGSSPHFSSRTLPRLHEGSGGGGSSRSSPTPAISGGHANQAANPSTSSSSCSILPNGQPINAKTIRVWQKGGVPVLPPVTALKRALISSSRNSPDEGYQEGCGTDV
Protein: Hexose-6-phosphate:phosphate antiporter (P0AGC0)
Organism: Escherichia coli (strain K12)
Function: Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphate. Also catalyzes the neutral exchange of internal and external phosphate.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2156798, ECO:0000269|PubMed:8402899}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:2156798}.
Interaction partners:
- Signal transduction histidine-protein kinase/phosphatase UhpB
- Transcriptional regulatory protein UhpA
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- Low-affinity inorganic phosphate transporter PitB
- Phosphoenolpyruvate-protein phosphotransferase
- Adenylate cyclase
- Membrane sensor protein UhpC
Sequence:
MLAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTVA
Protein: Carboxypeptidase (EC 3.4.16.-) (C8VMS9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MVSPSDESVLSSLLASWVTRVLPSLSMPSLTSVVGLSASLVGLVAGQYFPPTPEGVKVIHSKHQKGVTISYKEPEICETTPGVKSYSGYVHLPPGTLNDLGLDQQYPINTFFWFFESRNDPVNAPLSIWMNGGPGSSSMIGLMQENGPCRVNIDSNSTELNPWSWNNYVNMLYIDQPNQVGFSYDVPTNGTYNQLTGVRDVSGWSTVPEQNNTFYVGTFPSLNASATANTTENAARALWSFAQTWFTEFPAYKPRDDRVSIWTESYGGRYGPSFSAFFQEQNEKIANGSLTTPGESHYIHLDTLGIINGCIDLLVQAPSYPEIAYNNTYGIEAINETIYEFAMNAWSKPGGCKDQIVRCRQLAAEGDPRMYGNNKTVNAACQAADRYCSNNVEGPYPLFSGRGYYDIAHFDPDPFPPPYYLGYLSQHWVQDALGVHINFTESIDSVYNAFGTVGDYARSDVRGYLEDLAYVLDSGIKVALVYGDRDYACPWNGGEQVSLQVDYSHADKFRAAGYAPLHTNSSYVGGSVRQYGNFSFTRVYQAGHEVPAYQPETAYEIFHRAMFNRDIATGKISTAKNSTYSTKGPSSTWNVTNTVPDSPEPTCYILSLSSYCTEEQTQSVANGTALIKDYIVVEESL
Protein: Interferon gamma2 (E3P8T5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDVLSRAVMCFCLMGWMTLGWSNAAQYTSINMKRNIDKLKVHYKISKDQLFNGNPVFPKDTFEDSEQRVLMSVVLDVYLSIFSQMLNQTGDQEVRERLDQVKGKVQETQKHYFLGRIPELRTHLQNLWAIKTSDTTVQGKALSEFITIYEKASKLAHEIHLKKDNRRKRRQAQRLKSTHIM
Protein: Transcription factor MYC1 (AtMYC1) (Basic helix-loop-helix protein 12) (AtbHLH12) (bHLH 12) (Transcription factor EN 58) (bHLH transcription factor bHLH012) (Q8W2F1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trancsription activator, when associated with MYB75/PAP1 or MYB90/PAP2.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Protein TRANSPARENT TESTA GLABRA 1
- Transcription factor MYB23
- Transcription factor WER
- Trichome differentiation protein GL1
- Transcription factor TT2
- MYB-like transcription factor ETC2
- MYB-like transcription factor ETC1
- Homeobox-leucine zipper protein GLABRA 2
- MYB-like transcription factor ETC3
- Transcription repressor MYB5
Sequence:
MSLTMADGVEAAAGRSKRQNSLLRKQLALAVRSVQWSYAIFWSSSLTQPGVLEWGEGCYNGDMKKRKKSYESHYKYGLQKSKELRKLYLSMLEGDSGTTVSTTHDNLNDDDDNCHSTSMMLSPDDLSDEEWYYLVSMSYVFSPSQCLPGRASATGETIWLCNAQYAENKLFSRSLLARSASIQTVVCFPYLGGVIELGVTELISEDHNLLRNIKSCLMEISAHQDNDDEKKMEIKISEEKHQLPLGISDEDLHYKRTISTVLNYSADRSGKNDKNIRHRQPNIVTSEPGSSFLRWKQCEQQVSGFVQKKKSQNVLRKILHDVPLMHTKRMFPSQNSGLNQDDPSDRRKENEKFSVLRTMVPTVNEVDKESILNNTIKYLQELEARVEELESCMGSVNFVERQRKTTENLNDSVLIEETSGNYDDSTKIDDNSGETEQVTVFRDKTHLRVKLKETEVVIEVRCSYRDYIVADIMETLSNLHMDAFSVRSHTLNKFLTLNLKAKFRGAAVASVGMIKRELRRVIGDLF
Protein: Protein MICROTUBULE BINDING PROTEIN 2C (NtMBP2C) (Movement protein binding protein 2C) (TMV-MP30 binding protein 2C) (A0A1S3X835)
Organism: Nicotiana tabacum (Common tobacco)
Function: Prevents homeodomain proteins (e.g. STM) association to plasmodesmata and, consequently, cell-to-cell transport. Binds to RNA. Alters KN1 RNA-binding capacity. Regulates cytoskeleton (e.g. actin) organization that determinates cell shape (By similarity). Interferes with cell-to-cell transport of tobacco mosaic virus movement protein (TMV-MP) by mediating its accumulation at microtubules, thus interfering with cell-to-cell virus movement.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12913144}. Note=Microtubule-associated (PubMed:12913144). Localized in cytosolic punctae when associated with KN-1 (PubMed:17965274). {ECO:0000269|PubMed:12913144, ECO:0000269|PubMed:17965274}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein IMP3
- DEAD-box ATP-dependent RNA helicase 36
- DEAD-box ATP-dependent RNA helicase 36
- Something about silencing protein 10-like isoform X1
- Something about silencing protein 10 isoform X1
- U3 small nucleolar RNA-associated protein 25
- U3 small nucleolar RNA-associated protein 25
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor SYF2
Sequence:
MYKPQQQQQLFDLQDNNGAAFDNGGTDPSCWLSHENEISRTDSSLSSSNVDPLLFNDLVQIVPLVQSLIDRKEKSSFTRRGSMTYTKMPSRESLYKKTSEVKGRNAGQSTATKKHRDQNKNVSSSQDGYAENFSTPSSTSSLTEKDREELMTLREKVEDLQKKLLEKDELLKEAEILKNEITATNAELDEMKKDISEKDFLVKTTQVQLSDALVKLADKKAAVEKLEWEAMTSSKKVERLQEDLDLLQGEISSFIQFVHALTGNDSRDSAEECNVIPYPWDQNVEIDKLNERDLQKMEAAREAYIAAVAAAKENPDEASLSAASTARSYLQSLVLRT
Protein: Dorsal-ventral patterning protein tolloid (EC 3.4.24.-) (P25723)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for normal dorsal development. TLD may interact physically with DPP-C protein.
Interaction partners:
- Dorsal-ventral patterning protein Sog
- Protein decapentaplegic
- Protein twisted gastrulation
- Protein screw
- Protein tolkin
- Crossveinless 2
Sequence:
MKGMRLMPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGEDFDAVTPFPGYLKSMYSSETGSDHLLPPSRLI
Protein: Probable G-protein coupled receptor 173 (Super conserved receptor expressed in brain 3) (Q9NS66)
Organism: Homo sapiens (Human)
Function: Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Small integral membrane protein 20
Sequence:
MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM
Protein: Uncharacterized protein (Q57WW7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFAWLVGATEFLTSLPVQTNEAKEVFTRVFVGGMNVSVVLPPSALPTGESFNPSILVGQRSVCRNGSSNAHAVCTVFDAIPCLDLEVISEQVDCLEQILPCGVLFLGVMLSDTGGYSTIQLRSLLKENPRVNLLFAVIWGDSAVKKCELLQPGGRVELKVTTAEITFVSLPCYLVSPLDKLPLVLRARGRATTSSPIVDLRSSRLLADCDIWNLYKDIYAVQLGAKRDLDDELICVHVTFAPQHTCGLDIYRSIVSFIDKIGEQPQVRILRVCSLRNPALIYQWAYIHTTGDATGHTREQWRQVRELIEDGAGERLSSSRVLLEPHFTSTKMSVDKTSGEQQLLAAAGPGNVTDGDGRRNKGDYSLHVAVLVLISCAIGVLSWLLQTP
Protein: Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14) (P26022)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
Subcellular location: Secreted.
Interaction partners:
- Fibroblast growth factor 2
- Ficolin-1
- Tumor necrosis factor-inducible gene 6 protein
- Mannose-binding protein C
- Ficolin-2
- P-selectin
- Complement factor H-related protein 5
- Complement C1q subcomponent subunit B
- Complement factor H
- Fibroblast growth factor 13
Sequence:
MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS
Protein: Crystallin, isoform A (Crystallin, isoform B) (RH66281p) (Q9VKE2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein cycle
- Timeout
- F-box involved in polyQ pathogenesis, isoform A
- Circadian locomoter output cycles protein kaput
- Protein timeless
- Jetlag, isoform A
- Cryptochrome-1
Sequence:
MKRTYLLLCLSLLTCNVANSAYLRPIDLNQLAKSSNLQQQQQQQLRGALNRDDNNDDDDATTLAPNSNEDYDTRPQYSFAYDVRDSLTGDDKRQEEKRDGDLVKGQYSLIEPDGTRRIVEYTADDVSGFNAIVSKQRLDEQQQQRLSASTSSRFNSLEELQTRLTAQAIAEAQSLVEAQQASQLQLEAQNRRESENQARNQAQQLMEQFQQQVQQQEQQRLQQEQQLRDLQRLQEQRDREERDREQREREQREREQRERQQREQELRERELRERELRDRELRDRELRDREQRDREQRDREDRRQQAERRQSQNQRLLDQQTLLLAQSLPSIQATVVSHPPTLLATRLPVSTTTSSSRTTTLLTRERDLEAWRQLPNARITIDRSSQPLILSQPSSATVQAQLISSPLLLESGNLNGLITTRLNGNAARAGAALSWSNGRRLLNNDLWQLDRLDDRADNRRESEELRSNSAERRSKNW
Protein: AT02824p (Rho guanine nucleotide exchange factor 3, isoform E) (Q8IRJ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRIDKILVVSRGKASSVEVAALRYIAASIATATLDSQSQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSGGLGVLQKFKRTLNNFNNKNQLHISPLSPAAVAPMITTTTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRATMAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLSQPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTSTGSLGRRHFGNWFRKPKSANCTPSQSPTHKPSFDADATLTEARVAAMELAEAAAALVPTDSSSA
Protein: Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein) (O95965)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Runt-related transcription factor 2
- Core-binding factor subunit beta
Sequence:
MRPPGFRNFLLLASSLLFAGLSAVPQSFSPSLRSWPGAACRLSRAESERRCRAPGQPPGAALCHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCAGHGKCDCGKCKCDQGWYGDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCGRCKCDNSDGSGLVYGKFCECDDRECIDDETEEICGGHGKCYCGNCYCKAGWHGDKCEFQCDITPWESKRRCTSPDGKICSNRGTCVCGECTCHDVDPTGDWGDIHGDTCECDERDCRAVYDRYSDDFCSGHGQCNCGRCDCKAGWYGKKCEHPQSCTLSAEESIRKCQGSSDLPCSGRGKCECGKCTCYPPGDRRVYGKTCECDDRRCEDLDGVVCGGHGTCSCGRCVCERGWFGKLCQHPRKCNMTEEQSKNLCESADGILCSGKGSCHCGKCICSAEEWYISGEFCDCDDRDCDKHDGLICTGNGICSCGNCECWDGWNGNACEIWLGSEYP
Protein: GCN5-related N-acetyltransferase 6, chloroplastic (EC 2.3.1.255) (EC 2.3.1.48) (Q8GUT5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:32633465}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32633465}. Note=Spotted pattern, either associated with chloroplasts or confined within the nuclear envelope. {ECO:0000269|PubMed:32633465}.
Interaction partners:
- GCN5-related N-acetyltransferase 4, chloroplastic
- Acyl-CoA N-acyltransferases
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 8
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 1, chloroplastic
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- N-terminal acetyltransferase A complex catalytic subunit NAA10
- GCN5-related N-acetyltransferase 2, chloroplastic
- Nuclear protein
Sequence:
MSTISIHRTETLRITHARSRIFRQRYRRTIPLWKLTINSRSSDTSKKEELSVQISIPPQVDQSRPEGLRFDRLQPPEPEFGHEDRFEFGKFVAREAMLDEEYWTAAWLRAESHWEDRSNERYVDNYKRKFAEQEFNAIKRRCKGMQGQKCSCIVAVKKEEKHIKRSVIKSVVGTLDLSIRYFLQGETFPGEKVKSQLFCSINQEGSNRYGYIANLCVAKSARRQGIACNMLRFAVESARLSGVEQVYVHVHKNNSVAQELYQKTGFKIVETGKFESLDDDTYLLQYTS
Protein: Fe(3+)-pyochelin receptor (Fe(III)-pyochelin receptor) (P42512)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin.
Subcellular location: Cell outer membrane {ECO:0000255|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU01360}.
Interaction partners:
- Pyochelin synthetase PchE
- Pyochelin synthase PchD
- Pyochelin synthetase PchF
- Pyochelin biosynthetic protein PchG
- Salicylate biosynthesis isochorismate synthase
- Protein FptB
- Isochorismate pyruvate lyase
- Probable ATP-binding component of ABC transporter
- Uncharacterized protein PA4219
- Regulatory protein PchR
Sequence:
MKTETKVIKGRQGIARNRHTPLCLGLLLALSPLAAAVADARKDGETELPDMVISGESTSATQPPGVTTLGKVPLKPRELPQSASVIDHERLEQQNLFSLDEAMQQATGVTVQPFQLLTTAYYVRGFKVDSFELDGVPALLGNTASSPQDMAIYERVEILRGSNGLLHGTGNPAATVNLVRKRPQREFAASTTLSAGRWDRYRAEVDVGGPLSASGNVRGRAVAAYEDRDYFYDVADQGTRLLYGVTEFDLSPDTLLTVGAQYQHIDSITNMAGVPMAKDGSNLGLSRDTYLDVDWDRFKWDTYRAFGSLEQQLGGGWKGKVSAEYQEADSRLRYAGSFGAIDPQTGDGGQLMGAAYKFKSIQRSLDANLNGPVRLFGLTHELLGGVTYAQGETRQDTARFLNLPNTPVNVYRWDPHGVPRPQIGQYTSPGTTTTTQKGLYALGRIKLAEPLTLVVGGRESWWDQDTPATRFKPGRQFTPYGGLIWDFARDWSWYVSYAEVYQPQADRQTWNSEPLSPVEGKTYETGIKGELADGRLNLSLAAFRIDLENNPQEDPDHPGPPNNPFYISGGKVRSQGFELEGTGYLTPYWSLSAGYTYTSTEYLKDSQNDSGTRYSTFTPRHLLRLWSNYDLPWQDRRWSVGGGLQAQSDYSVDYRGVSMRQGGYALVNMRLGYKIDEHWTAAVNVNNLFDRTYYQSLSNPNWNNRYGEPRSFNVSLRGAF
Protein: Protein RIK (Rough sheath 2-interacting KH domain protein) (RS2-interacting KH domain protein) (Q32SG5)
Organism: Zea mays (Maize)
Subcellular location: Nucleus {ECO:0000269|PubMed:16243907}.
Interaction partners:
Sequence:
MTEDRAHKVADEPAASGRQSPERKKRKWDQPAEDLVSAAVTAAAVSGMPVMNFGALPGVVLPGVTAYGAATLPSVVPVPYSLPPHIAPSVLQNAAAAAQKLSQAKIPDEVIAREIVINDADPSVRYKLTKRQTQEEIQKCTNTVIITRGKYHPPNLLPDGEKPLYLHISAGSQLKDTAERIKAVDRAASMIEEILKQGTTSESISVPFSSSTGQAVRPFSASVFLGFDADPSLNITARIRGPNDQYINHIMKETGVTVVLRGKDSENLGSCHSEASQQPLHLYLTSMHLKNLEAAKVLAENLLDTVAAEFGASRISSSKVYGAVPPPQQLLAGVDTSGTKSDVHYIVGPNVLSGATHSFASTGVIAPVVAPAVTVQSGAPTYSGVPLPSNMAYPIPPANGGAFYSGYGDIYPQATPLQQLAFTLKHASSSATQAVPVTSTPTSMATKGNSILDAEMDKRSRRKFQELPVSKGPATESQNSQQGSKFVKTGLDSSGNIGSSSIAPPKKVHPGSNGMLPQEEADMPSHLSISTKMLPPPLKSMLPLPPRSMPPPPPKSMPPPPPKFPSDEFLSRNENKFFPLKEPTAPPRSFDAISVLPSERRPREPKEEKNKRHTCV
Protein: D(1A) dopamine receptor (Dopamine D1 receptor) (H0YPZ4)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cell projection, cilium membrane {ECO:0000256|ARBA:ARBA00004272}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004272}.
Interaction partners:
- Guanine nucleotide-binding protein G
- G protein subunit alpha L
Sequence:
MTWNETTMDGEGLLVERDSSSFRILTGCFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFIMISVAWTLSVLISFIPVQLNWHKATTTSFLDFNATLEGVSTDNCDSSLNRMYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCHNPGGNRSSMDCQQPESNFKMSFKRETKVLKTLSVIMGVFVCCWLPFFVLNCMIPFCEPTQPSKGAEAFCINSTIFDVFIWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPMSGHAIETVSINNNGAVVFSSQHEPKGSSPKESNLVYLIPHSIICPEEEPLKKEDEEGEMSKTLEKMSPALSGILDYEADVSLEKINPITQNGQHKT
Protein: SIN3 transcription regulator family member A (H3BNZ3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQ
Protein: Cupin type-2 domain-containing protein (G8BL04)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- FAD-binding domain-containing protein
- Fumarylacetoacetase-like C-terminal domain-containing protein
Sequence:
MSPVEASTNEKVEFLKSLKPQNVEPLWTVMSAMVPPVPKPRAVPAVWNYKKLRPLLVESGRLVPTEESERRVLMLINPALKAPQTTDTLYAGLQYINPGEVAPAHRHSAFALRFIIEGDGGYTAVEGQRIYMERGDVILTPRWDWHDHGKEGDGPMIWLDGLDLPMFQAIPVNFAEHYHEECYPAETVAESNIKFPWKITQDYLDSIESDYAVFDYTGQNKAPLSTILTAQAERVNVGSSSEWRQENSSFVYHVYEGAGYTAIEEDNGEETILRWEGKDTFCIPAWKRFKHVNDGVQTAYLFSFNDSPLLKNLAIHKTAAN
Protein: Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) (P21397)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21396}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P21396}; Cytoplasmic side {ECO:0000250|UniProtKB:P21396}.
Interaction partners:
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase
- Dopamine beta-hydroxylase
- Aromatic-L-amino-acid decarboxylase
- Aldehyde dehydrogenase, mitochondrial
- Amine oxidase [copper-containing] 2
- Diamine oxidase [copper-containing]
- Amine oxidase [flavin-containing] B
- Cytochrome P450 2D6
- Amine oxidase [copper-containing] 3
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Protein: Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) (Q14145)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15657435, ECO:0000269|PubMed:19424503}. Nucleus {ECO:0000269|PubMed:15657435}. Note=Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972). {ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:20452972}.
Interaction partners:
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- Sequestosome-1
- Nuclear factor erythroid 2-related factor 2
- Endonuclease 8-like 2 lyase Neil2)
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Partner and localizer of BRCA2
- Prothymosin alpha
- Dipeptidyl peptidase 3
Sequence:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
Protein: Pentatricopeptide repeat-containing protein At1g79540 (Q9SAJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKPQMFFRSVIQFYSKPSWMQRSYSSGNAEFNISGEVISILAKKKPIEPALEPLVPFLSKNIITSVIKDEVNRQLGFRFFIWASRRERLRSRESFGLVIDMLSEDNGCDLYWQTLEELKSGGVSVDSYCFCVLISAYAKMGMAEKAVESFGRMKEFDCRPDVFTYNVILRVMMREEVFFMLAFAVYNEMLKCNCSPNLYTFGILMDGLYKKGRTSDAQKMFDDMTGRGISPNRVTYTILISGLCQRGSADDARKLFYEMQTSGNYPDSVAHNALLDGFCKLGRMVEAFELLRLFEKDGFVLGLRGYSSLIDGLFRARRYTQAFELYANMLKKNIKPDIILYTILIQGLSKAGKIEDALKLLSSMPSKGISPDTYCYNAVIKALCGRGLLEEGRSLQLEMSETESFPDACTHTILICSMCRNGLVREAEEIFTEIEKSGCSPSVATFNALIDGLCKSGELKEARLLLHKMEVGRPASLFLRLSHSGNRSFDTMVESGSILKAYRDLAHFADTGSSPDIVSYNVLINGFCRAGDIDGALKLLNVLQLKGLSPDSVTYNTLINGLHRVGREEEAFKLFYAKDDFRHSPAVYRSLMTWSCRKRKVLVAFNLWMKYLKKISCLDDETANEIEQCFKEGETERALRRLIELDTRKDELTLGPYTIWLIGLCQSGRFHEALMVFSVLREKKILVTPPSCVKLIHGLCKREQLDAAIEVFLYTLDNNFKLMPRVCNYLLSSLLESTEKMEIVSQLTNRMERAGYNVDSMLRFEILKYHRHRKQVLIDL