wanglab/gogpt-training-data huggingface dataset:
Protein: X-box-binding protein 1 (Q90X27)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Activating transcription factor 6
- DNA damage-inducible transcript 3 protein
- Immunoglobulin binding protein
- Cyclic AMP-dependent transcription factor ATF-4
- Endoplasmic reticulum to nucleus-signaling 2.
- Eukaryotic translation initiation factor 2-alpha kinase 3
- Endoplasmin
- Mesencephalic astrocyte-derived neurotrophic factor.
- alpha-1,2-Mannosidase
- FAU ubiquitin-like and ribosomal protein S30 fusion b
Sequence:
MVVVTAGTGGAHKVLLISGKQSASTGATQGGYSRSISVMIPNQASSDSDSTTSGPPLRKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKAKMGELEQQVLELELENQKLHVENRLLRDKTSDLLSENEELRQRLGLDTLETKEQVQVLESAVSDLGLVTGSSESAALRLRVPPQQVQAQQSPNLKTSPWILTALALQTLSLISCLVFWTSLTPSSSSRQTFLKHRSLSRSSCWWGVQESKYLPPHLQLWGPHQLSWKPLMN
Protein: Secreted serine protease (Q9K3X9)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Interaction partners:
- Subtilase-type protease inhibitor
- Probable secreted protease
Sequence:
MKLRKFDARAIRGLLAAGATSALLVGAAAVNGAAAPVPPDDRGHIVGADRAGAVEGSYIVTLKDNVARADVPASAKALAKRHGGSLRYTYTTALRGFAVKMTERRAEELAADPSVARVEADAVAYAVGTQPDPPSWGLDRIDQRDLPVDRSYTYPGGAPDVTAYVVDTGVRLSHNDFGGRAVSGYDFIDDDSNASDCQGHGTHVAGTVGGASHGVAKAVRLVGVRVLNCQGTSGNTWAPVLAGIDWVTRNADGPSVANMSIGGGRTQSVNDAVDASVASGVTWVVAAGNNNADACSYSPSSTPAAVTVGATDSRDARASGWSNGQGSNYGSCLDIFAPGDTIVSASNAGDSASRADSGTSMASPHVAGAAALLLSAHPDWSPAQVRDRLVADATSGKVTDPRNGSPNRLLFTGTGDDTQPPTDGERFENTDDHPIRDGATVESPLTVTGVSGNAPADLSVTVDIRHTYRGDLRVELVAPDGDVFLLKDYAAYDGTDDVRGTFAVNASGKPANGTWKLRVSDNWVNDTGHVDAWSLRF
Protein: Truncated Kidins220 isoform m3 (A0A076NBC4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
VRAAREQINIGGLAYPPLPLHEAPPRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSSVKTSLPRDQNNGLLCDSGFNKQRQASVPATGTSLLLSSMTVDIVCEKLRQIEGLDQGMLPQYCTTIKKANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSAPVAHGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSNLEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSICSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTGFGEERESIL
Protein: Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) (Q9Y4P3)
Organism: Homo sapiens (Human)
Interaction partners:
- Carbohydrate-responsive element-binding protein
- B-cell CLL/lymphoma 7 protein family member B
- CAP-Gly domain-containing linker protein 2
- General transcription factor II-I repeat domain-containing protein 1
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- Eukaryotic translation initiation factor 4H
- E3 ubiquitin-protein ligase TRIM50
- Peptidyl-prolyl cis-trans isomerase FKBP10
- GDP-fucose protein O-fucosyltransferase 1
- Tyrosine-protein kinase BAZ1B
Sequence:
MELSQMSELMGLSVLLGLLALMATAAVARGWLRAGEERSGRPACQKANGFPPDKSSGSKKQKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECFERVHGECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGHLKRASNESTRQRLQQQLTQAQETLKSLGALKK
Protein: Kitb (Q5EGE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
FKFQTGDGYYKHLLSQTQPSIEGTDNGYMPMRSYQKRSNQTEWCDDKDDLSLDTEDLLSFSYQVAKGMDFLTSKNCIHRDLAARNVLLTQGRVAKICDFGLARDITRDSNYVLRGNARLPVKWMSPESLFACVYTFESDVWSYGILLWEIFSLGNTPYPGIPVGSTFYKMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKLVERTELLLSETTKHVPYSE
Protein: Squamosa promoter-binding-like protein 7 (Q8S9G8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that participates in reprogramming global gene expression during copper deficiency in order to improve the metal uptake and prioritize its distribution to copper proteins of major importance (Probable). Binds directly to 5'-GTAC-3' motifs in the microRNA (miRNA) promoter of the stress-responsive miRNAs miR398b and miR398c to activate their transcription. During copper deficiency, activates the copper transporters COPT1 and COPT2, and the copper chaperone CCH, directly or indirectly via miRNAs. Required for the expression of the miRNAs miR397, miR408 and miR857. Acts coordinately with HY5 to regulate miR408 and its target genes in response to changes in light and copper conditions. Activates miR857 and its target genes in response to low copper conditions. Involved in cadmium stress response by regulating miR397a, miR398b, miR398c and miR857. Required for iron homeostasis during copper deficiency.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:24335506}. Note=Nuclear localization with a speckled distribution pattern. {ECO:0000269|PubMed:24335506}.
Interaction partners:
- Copper transporter 2
- Copper transporter 6
- Copper transporter 1
- Ferric reduction oxidase 4
- KIN17-like protein
- Transcription factor HY5
- Ferric reduction oxidase 5
- Superoxide dismutase 1
- Copper transport protein CCH
- Superoxide dismutase 1, chloroplastic
Sequence:
MSSLSQSPPPPEMDIQPPALVNDDPSTYSSALWDWGDLLDFAADERLLVDQIHFPPVLSPPLPPLIPTQTPAESELDPSPEESGSGSDRVRKRDPRLICSNFIEGMLPCSCPELDQKLEDAELPKKKRVRGGSGVARCQVPDCEADISELKGYHKRHRVCLRCATASFVVLDGENKRYCQQCGKFHLLPDFDEGKRSCRRKLERHNNRRKRKPVDKGGVAAEQQQVLSQNDNSVIDVEDGKDITCSSDQRAEEEPSLIFEDRHITTQGSVPFTRSINADNFVSVTGSGEAQPDEGMNDTKFERSPSNGDNKSAYSTVCPTGRISFKLYDWNPAEFPRRLRHQIFQWLANMPVELEGYIRPGCTILTVFIAMPEIMWAKLSKDPVAYLDEFILKPGKMLFGRGSMTVYLNNMIFRLIKGGTTLKRVDVKLESPKLQFVYPTCFEAGKPIELVVCGQNLLQPKCRFLVSFSGKYLPHNYSVVPAPDQDGKRSCNNKFYKINIVNSDPSLFGPAFVEVENESGLSNFIPLIIGDAAVCSEMKLIEQKFNATLFPEGQEVTACSSLTCCCRDFGERQSTFSGLLLDIAWSVKVPSAERTEQPVNRCQIKRYNRVLNYLIQNNSASILGNVLHNLETLVKKMEPDSLVHCTCDCDVRLLHENMDLASDIHRKHQSPIESKVNPPSSGCCCVSSQKDIPSRILNFNKDPEAGLDCKERIQADCSPDSGGKETDPLLNKEVVMNVNDIGDWPRKSCIKTHSALAFRSRQTMFLIATFAVCFAVCAVLYHPNKVTQLAVAIRMRLVHKI
Protein: Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Q5E268)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Interaction partners:
- Citrate synthase
- Malate synthase
- Aldehyde-alcohol dehydrogenase
- Fatty acid oxidation complex subunit alpha
- Fatty acid oxidation complex subunit alpha
- Malate synthase
- Phosphate acetyltransferase
- Biotin carboxylase
- 2-isopropylmalate synthase
- Acetate kinase 2
Sequence:
MSEIHVYPVNQDIANNAHADDDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSANCIDRHLATRGNDVAIIWEGDDPQDDASITFNELHEQVCKFSNTLKSQGVRKGDVVCIYMPMVAEAAVAMLACTRIGAVHTVVFGGFSPEALAGRIIDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPDVTTIEKVVVFQRTGNDIEWSEGRDVWWHEATAVASPHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAITFKYIFDYQEGEVFWCTADVGWITGHTYLIYGPLANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAQGTEAVQGTSRSSLRVMGSVGEPINPEAWEWYYNTIGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVITDSWPGQMRTIYGDHDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVAFDKIAEAAIVGVPHDIKGQAIYAYITLNSGEIPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDKLIEEQRKIA
Protein: Histone H2B (Q389T1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000451}.
Interaction partners:
- Histone H2A
- Histone H3, putative
- Histone H4
- Histone H3 variant
- Histone H4
- Histone H2A
- Cell division control protein 73 C-terminal domain-containing protein
- SET domain-containing protein
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
Sequence:
MATPKSTPAKTRKEAKKTRRQRKRTWNVYVSRSLRSINSQMSMTSRTMKIVNSFVNDLFERIAAEAATIVRVNRKRTLGARELQTAVRLVLPADLAKHAMAEGTKAVSHASS
Protein: Ubiquitin 13 (F4I9X6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
- Protein NBR1 homolog
- E3 ubiquitin-protein ligase PRT1
- Ubiquitin-conjugating enzyme E2 13
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- Ubiquitin-conjugating enzyme E2 variant 1A
- E3 ubiquitin-protein ligase UPL5
Sequence:
MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEWIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSGTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEGGPGGGGGHFQKAEALAFLADYNIQKESTLHLVLRLRGGSF
Protein: Pancreatic lipase-related protein 2 (PL-RP2) (Cytotoxic T lymphocyte lipase) (GPL) (Galactolipase) (EC 3.1.1.26) (Triacylglycerol lipase) (EC 3.1.1.3) (P81139)
Organism: Cavia porcellus (Guinea pig)
Function: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (By similarity). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (By similarity). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P54317}. Zymogen granule membrane {ECO:0000250|UniProtKB:P54318}; Peripheral membrane protein {ECO:0000250|UniProtKB:P54318}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P54318}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:P54318}.
Interaction partners:
- Colipase
- Carboxylic ester hydrolase
- Phospholipid phosphatase 2
- O-acyltransferase
- Phospholipid phosphatase 4
- Phospholipid phosphatase 5
- Patatin-like phospholipase domain-containing protein 2
- Acylglycerol kinase, mitochondrial
- Acyltransferase
- Acyltransferase
Sequence:
AEVCYSHLGCFSDEKPWAGTSQRPIKSLPSDPKKINTRFLLYTNENQNSYQLITATDIATIKASNFNLNRKTRFIIHGFTDSGENSWLSDMCKNMFQVEKVNCICVDWKGGSKAQYSQASQNIRVVGAEVAYLVQVLSTSLNYAPENVHIIGHSLGAHTAGEAGKRLNGLVGRITGLDPAEPYFQDTPEEVRLDPSDAKFVDVIHTDISPILPSLGFGMSQKVGHMDFFPNGGKDMPGCKTGISCNHHRSIEYYHSSILNPEGFLGYPCASYDEFQESGCFPCPAKGCPKMGHFADQYPGKTNAVEQTFFLNTGASDNFTRWRYKVTVTLSGEKDPSGNINVALLGKNGNSAQYQVFKGTLKPDASYTNSIDVELNVGTIQKVTFLWKRSGISVSKPKMGASRITVQSGKDGTKYNFCSSDIVQENVEQTLSPC
Protein: Spermatid perinuclear RNA-binding protein (Q96SI9)
Organism: Homo sapiens (Human)
Function: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.
Interaction partners:
- Interferon-induced, double-stranded RNA-activated protein kinase
- Interleukin enhancer-binding factor 2
- RISC-loading complex subunit TARBP2
- Heterogeneous nuclear ribonucleoprotein R
- Probable ATP-dependent RNA helicase DDX17
- Polymerase delta-interacting protein 3
Sequence:
MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWLDETNKGTKTEGETEVKKDEAGENYSKDQGGRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCVNEASIIIRNTKEPTLTLKVILTSPLIRDELEKKDGENVSMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCERDPTDALSYMTIQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSKPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQAMGYPTGFDADIECMSSDEKSDNESKNETVSSNSSNNTGNSTTETSSTLEVRTQGPILTASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASAALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGATAAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF
Protein: Amino acid transporter, putative (Q57UX7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLSPTEPLGSGKAHTEVVTDEGEGYGAMSAADEKSHHKNGDTPTTDSKFMQCINAIIPHGGALSTTFNLGSATLGAGVISLAIAFQMSGVIPSILILITVTVLTIYSVGLMMQAVEMTGYNSYTDLSRNLFGPGWDYFTISVSWLFTFGTCVSYVIATGYLVGSVASGCTTLEFFQGKTGNRVITSIIWFVGMFSLSLPKEINSLRYASAIAVLFVFYFVICIVVHSAKNGLKDGKLPEDVEMFKSGNRAIEGLSIFMFSYLCHMNCFSIYSEMRKPSARRMTLHTTYSMSMCCVVYIIAGFFGYTDVGNKSVETVFEIYDVKGDVMMAIAFAGMLLKICVGFSLCMQPARDCCYYIIGWDLNTLETWKNCLFCGCMALCALLLGLFIPDLNTVFGLLGSFCGGVLGFCIPALYRMYCGNWGISQVGVVNYVCTYLLLISGVIAVVFGTAASIYNVAV
Protein: Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) (P31648)
Organism: Mus musculus (Mouse)
Function: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000269|PubMed:15234345}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000269|PubMed:15234345}.
Interaction partners:
- Cytosolic arginine sensor for mTORC1 subunit 2
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Vesicular inhibitory amino acid transporter
- Gamma-aminobutyric acid receptor subunit gamma-2
- Parvalbumin alpha
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
Protein: Transcription factor Dp-2 (E2F dimerization partner 2) (Q14188)
Organism: Homo sapiens (Human)
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor E2F4
- Transcription factor E2F1
- Transcription factor E2F6
- Transcription factor E2F5
- Retinoblastoma-associated protein
- Retinoblastoma-like protein 2
- Retinoblastoma-like protein 1
- Transcription factor E2F2
- Transcription factor E2F3
- Transcription factor Dp-1
Sequence:
MTAKNVGLTSTNAEVRGFIDQNLSPTKGNISFVAFPVSNTNSPTKILPKTLGPINVNVGPQMIISTPQRLTSSGSVLIGSPYTPAPAMVTQTHIAEATGWVPGDRKRARKFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNSNNHLAADSAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPNSHQSSSAASHCSESRGETPCSFNDEDEEDDEEDSSSPE
Protein: Lipoprotein, putative (O53253)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MWTTRLVRSGLAALCAAVLVSSGCARFNDAQSQPFTTEPELRPQPSSTPPPPPPLPPVPFPKECPAPGVMQGCLESTSGLIMGIDSKTALVAERITGAVEEISISAEPKVKTVIPVDPAGDGGLMDIVLSPTYSQDRLMYAYISTPTDNRVVRVADGDIPKDILTGIPKGAAGNTGALIFTSPTTLVVMTGDAGDPALAADPQSLAGKVLRIEQPTTIGQTPPTTALSGIGSGGGLCIDPVDGSLYVADRTPTADRLQRITKNSEVSTVWTWPDKPGVAGCAAMDGTVLVNLINTKLTVAVRLAPSTGAVTGEPDVVRKDTHAHAWALRMSPDGNVWGATVNKTAGDAEKLDDVVFPLFPQGGGFPRNNDDKT
Protein: Lipophorin receptor 2, isoform I (A0A0B4KGZ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGPICRILGCSFLLLIAGLVPHHASRVVGLESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCNRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLETKTGNNRTDTSNQVHKSDAESENDYVEIALHVIASLAGTALVASVIYVVYRRCTRAVNSMNFENPVYHKTTEDHFSLEKNGTPHIYAAANDEEVSGSAPPMATNPNDFSYVRF
Protein: Uncharacterized protein (Q386T5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVSEVMVELHDFVHGGGLQDSSYVPLNSPLRLRFQYSVSHTVEKPKWALTFVADIADKRRVVELLPPMNVKNELMHEPYKTYDGVPPLSPGERYVAEFQIETMNLTGVERKYLEHVGALQLVLMSDTKRVSELTVVVQVKRNDSGELMRRVLSPMV
Protein: Calcipressin-like protein (Down syndrome candidate region 1-like protein) (Regulator of calcineurin 1) (P36054)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
- Transcriptional regulator CRZ1
- Serine/threonine-protein phosphatase 2B catalytic subunit A2
- Vacuolar calcium ion transporter
- Calcineurin subunit B
- Calcium-transporting ATPase 2
- Calcium-transporting ATPase 1
- Regulator of calcineurin 2
Sequence:
MGNIITDTIIITSDKCDIVDNDNVERIQVWLSKNILRKFQINENEPLQLIILKRFKRILLICPSHDISQHVMDASRALEMENFNFSYSLQDGQRNLTKQYLKVPESEKMFLISPPASPPPEFDFSKCEDAPQRHIQSHIQQDQQQRLEASQLLPNNPDKNNNGTFTLLKSKVGAITIDRCPTNDGNGQMQLADHVKTAFPPKSIFDTDDDD
Protein: Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) (P28840)
Organism: Rattus norvegicus (Rat)
Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Subcellular location: Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Interaction partners:
- Pro-opiomelanocortin
- Appetite-regulating hormone
- Receptor-interacting serine/threonine-protein kinase 3
- Mixed lineage kinase domain-like protein
- Receptor-interacting serine/threonine-protein kinase 1
- Carboxypeptidase E
Sequence:
MKQRGWTLQCTAFTLFCVWCALNSVKAKRQFVNEWAAEIHGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSALHITKRLSDDDRVIWAEQQYEKERRKRSVPRDSALNLFNDPMWNQQWYLQDTRMTASLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKVTDMSGRMQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVNVVEEKPTQNSLNGNLLVPKNSSSSSVEDRRDEQVQGAPSKAMLRLLQSAFSKNTPSKQSSKIPSAKLSVPYEGLYEALEKLNKPSQLEDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEKN
Protein: IpaA (Q6XVZ2)
Organism: Shigella flexneri
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MHNVNNTQAPTFLYKATSPSSTEYSELKSKISDIHSSQTSLKTPASVSEKENFATSFNQKCLDFLFSSSGKEDVLRSIYSNSMNAYAKSEILEFSNVLYSLVHQNDLNFENEKGLQKIVAQYSELIIKDKLSQDSAFGPWSAKNKKLHQLRQNIEHRLALLAQQHTSGEALSLGQKLLNTEVSSFIKNNILAELKLSNETVSSLKLDDLVDAQAKLAFDSLRNQRKNTIDSKGFGIGKLSRDLNTVAVFPELLRKVLNDILEDIKDSHPIQDGLPTPPEDMPDGGPTPGANEKTSQPVIHYHINNDNRTYDNRVFDNRVYDNSYHENPENDAQSPTSQTNDLLSRNGNSLLNPQRALVQKVTSVLPHSISDAVQTFANNSALEKVFNHTPDNSDGIGSDLLTTSSQERSTNNSLSRGHRPLNIQNSSTTPPLHPEGVTSSNDNSSDTTKSSASLSHRVASQINKFNSNTDSKVLQTDFLSRNGDTYLTRETIFEASKKVTNSLSNLISLIGTKSGTQERELQEKSKDITKSTTEHRINNKLKVTDANTINYVTETNADTIDKNHAIYEKAKEVSSALSKVLSKIDDTSAELLTDDISDLKNNNDITAENNNIYKAAKDVTTSLSKVLKNINKD
Protein: Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) (Q04726)
Organism: Homo sapiens (Human)
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:1303260, ECO:0000269|PubMed:22304967}.
Interaction partners:
- Transducin-like enhancer protein 1
- Histone deacetylase 1
- Transducin-like enhancer protein 4
- Hepatocyte nuclear factor 3-alpha
- Homeobox protein Nkx-2.2
- Catenin beta-1
- TLE family member 5
- Transcription factor 4
- LIM domain-binding protein 1
- Transducin-like enhancer protein 2
Sequence:
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY