wanglab/gogpt-training-data huggingface dataset:
Protein: Chaperone protein DNAJ, putative (Q38EE7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
Sequence:
MLGRKCSGSLYTLMEVNENATPQEIKRAYHRLALILHPDKTDGTTTEQFTRLQEAYSILSDEQQRRTYNTFGREGVATLNKLNEMNVPVNPSAFRFLCFLVMMLILLLLLQLELVVVRLDYELSWKWPVVFIPLWIALAPPILLALGLLAAGIKQLDFLCVCVGVEILLFVGSIATFVAGLCGALSWPVALSPAIAFYAVRVLHIIPHLFPSRFVQNSEDGSGEVTFSRKKYCLFVVMVLFEEGCAIAFFTLLMLRAMQKSEESKDEPLSFWIVFSPLIACLGLKALLHLCFCMICSKVEQPNQQASQKSTSAFLFVVYSSMIYVACMIAAKANVEINKWTDGFNPSAAVAVIPIQVIFISLFLASVIMFCTASRVYEAMLFGVANEEDDAERGATTPLSPRNTGASNSFRCETVPGEHQQRKRGADEVV
Protein: Uncharacterized protein (Q57YL4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDTTTSSDFTEELFSVLLESCTPSRSRVETLTQIALRNLPCATATWSALRRAFVRQQELESDENKALWYVLDSLMKHAPHVFIPLVAPRLFDFVVQQLPWHLAGVVSTYGSGALWCDSMIRTWEGLLPPLLFRTVNSFVVQLRGGKELSQAMNPNDADEEIQTIDFPATREEMQQLQEAWDVFRTFAAEGAVNRAGATPTTPGDVVKTEQTTTAVVATAEVCVKQEPSLTTAGVVKSEYGAHAGVNTDDEDDSDVEYIPVFVRGAQRRELPPLTNENGTAPRPRRAARRRPRDDGE
Protein: Direct IAP-binding protein with low pI (A0A0S2Z5U7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED
Protein: Kelch-like protein 2 (Actin-binding protein Mayven) (O95198)
Organism: Homo sapiens (Human)
Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10397770, ECO:0000269|PubMed:15715669}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8JZP3}. Cell projection {ECO:0000269|PubMed:15715669}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:F1LZF0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8JZP3}. Note=A proportion colocalizes with the actin cytoskeleton (PubMed:10397770). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770}.
Interaction partners:
- Cullin-3
- Kelch-like protein 3
- Kelch-like protein 12
- Kelch-like ECH-associated protein 1
- Serine/threonine-protein kinase WNK4
- Kelch-like protein 9
- Ectoderm-neural cortex protein 1
- Kelch-like protein 13
- Speckle-type POZ protein-like
- E3 ubiquitin-protein ligase RBX1
Sequence:
METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL
Protein: Spichthyin, isoform B (M9PD12)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein spartin
- GH11935p
Sequence:
MNSDGEASSLQMPQVTVGGMLPVEANQSPETAPLSMAETVSNTDFYIGVGLAISSCFFIGSSFIIKKKALIRLSRYGEVRASAGGFGYLREWIWWAGLLTMGVGEAANFAAYAFAPASLVTPLGALSVIISAVMASRFLNEKLNLLGKIGCFLCILGSTIIVIHSPKEKEIEDLQLLFDMLLDPVFILYVICIVGSTVFVACFIAPRHGHTNVVVYIFLCSGIGSLTVMSCKALGLAIRQTLNNGGNVFLTWMPWFLILVTVTFIAIQMNYLNKALDIFNTSIVTPVYYVMFTTLVIAASAILFKEFTHMRFDDILGDVCGFLIVITAVFLLNAFRDIDISLNDVRGLMRPKMQRVSQFDEEVLVTSNTKERRLSYGSSDIFRKAXHKQRYQV
Protein: cDNA FLJ12440 fis, clone NT2RM1000131, highly similar to Homo sapiens transmembrane protein 63A (TMEM63A), mRNA (B3KMR6)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MMDSPFLELWQSKAVSIREQLGLGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLILVFSIIRRRFWDYGRIALVSEADSESRFQRLSSTSSSGQQDFENELGCCPWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNDLLWLHTIFAVIYLFFTVGFMRHHTQSIKYKEENLVRRTLFITGLPRDARKETVESHFRDVYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRTLINPKPCGQFCCCEVLGCEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKDFNACKCQSLQCKGEPQPSSHSRELYTSKWTVTFAADPEDICWKNLSIQGLRWWLQWLGINFTLFLGLFFLTTPSIILSTMDKFNVTKPIHALNNPIISQFFPTPLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFQYEFGAMYAWMLCVFTAIVAYSITCPIIAPFGLTYILLKHMVDRHNLYFVYLPAKLEKGIHFAAVNQALAAPILCLFWLYFFSFLRLGMKAPATLFTFLVLLLTILVCLAHTCFGCFKHLSPLNYKTEEPASDKGSEAEAHMPPPFTPYVPRILNGLASERTALSPQQQQQQTYGAIHNISGTIPGQCLAQSAAGSVAAAPQEA
Protein: SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) (Q8IX01)
Organism: Homo sapiens (Human)
Function: May play a role in mRNA splicing.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Matrin-3
Sequence:
MAARRITQETFDAVLQEKAKRYHMDASGEAVSETLQFKAQDLLRAVPRSRAEMYDDVHSDGRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSYFRKECGRDLEFSHSDSRDQVIGHRKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQEYSFGPSAVLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGGSQVQARGRALNIVDQEGSLLGKGETQGLLTAKGGVGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTPSPDVTLGTNPGTEDIQFPIQKIPLGLDLKNLRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLSDAVPQRADHRVVGTIDQLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSRAVRNLKKKLLPWQRRGLLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASGPSPKPAGVDISEAPQTSSPCPSADIDMKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPHNLHTGGGDTTGSQESPVDLMEGEAEFEDEPPPREAELESPEVMPEEEDEDDEDGGEEAPAPGGAGKSEGSTPADGLPGEAAEDDLAGAPALSQASSGTCFPRKRISSKSLKVGMIPAPKRVCLIQEPKVHEPVRIAYDRPRGRPMSKKKKPKDLDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGADGQEHKEDTFDVFRQRMMQMYRHKRANK
Protein: Protein DELAY OF GERMINATION 1 (GLUCOSE SENSING QTL 5) (A0SVK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the induction of seed dormancy. The level of DOG1 protein in freshly harvested seeds determines the level of seed dormancy. Determines the temperature window for germination by regulating the expression of micropylar endosperm-weakening genes through temperature control of the gibberellins metabolism. Regulates seed dormancy and flowering time through an influence on levels of microRNAs miR156 and miR172. Regulator of seed maturation interfering with abscisic acid signaling components and activating ABI5. In cv. Cvi-1, enhances glucose induction of ABI4.
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22829147, ECO:0000269|PubMed:26620523, ECO:0000269|PubMed:26684465}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:26620523}.
Interaction partners:
- Probable protein phosphatase 2C 75
- B3 domain-containing transcription factor ABI3
- Protein phosphatase 2C 37
- Short-chain dehydrogenase reductase 4
- Short-chain dehydrogenase reductase 3a
- Abscisic acid 8'-hydroxylase 2
- Protein ABSCISIC ACID-INSENSITIVE 5
- Ethylene-responsive transcription factor ABI4
- Protein MOTHER of FT and TFL1
- B3 domain-containing transcription factor FUS3
Sequence:
MGSSSKNIEQAQDSYLEWMSLQSQRIPELKQLLAQRRSHGDEDNDNKLRKLTGKIIGDFKNYAAKRADLAHRCSSNYYAPTWNSPLENALIWMGGCRPSSFFRLVYALCGSQTEIRVTQFLRNIDGYESSGGGGGASLSDLSAEQLAKINVLHVKIIDEEEKMTKKVSSLQEDAADIPIATVAYEMENVGEPNVVVDQALDKQEEAMARLLVEADNLRVDTLAKILGILSPVQGADFLLAGKKLHLSMHEWGTMRDRRRRDCMVDTEVIFDACTTVNSGPRPTETTNNERN
Protein: mRNA export factor ICP27 homolog (P16749)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs. Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H. In addition, acts as a post-transcriptional transactivator that mediates the nuclear export of unspliced mRNAs via interaction with DDX39B, a component of the cellular mRNA export machinery.
Subcellular location: Virion tegument. Virion. Host nucleus {ECO:0000269|PubMed:26178996}. Host cytoplasm. Note=Shuttles between host nucleus and cytoplasm. {ECO:0000269|PubMed:26178996}.
Interaction partners:
Sequence:
MELHSRGRHDAPSLSSLSERERRARRARRFCLDYEPVPRKFRRERSPTSPSTRNGAAASEHHLAEDTVGAASHHHRPCVPARRPRYSKDDDTEGDPDHYPPPLPPSSRHALGGTGGHIIMGTAGFRGGHRASSSFKRRVAASASVPLNPHYGKSYDNDDGEPHHHGGDSTHLRRRVPSCPTTFGSSHPSSANNHHGSSAGPQQQQMLALIDDELDAMDEDELQQLSRLIEKKKRARLQRGAASSGTSPSSTSPVYDLQRYTAESLRLAPYPADLKVPTAFPQDHQPRGRILLSHDELMHTDYLLHIRQQFDWLEEPLLRKLVVEKIFAVYNAPNLHTLLAIIDETLSYMKYHHLHGLPVNPHDPYLETVGGMRQLLFNKLNNLDLGCILDHQDGWGDHCSTLKRLVKKPGQMSAWLRDDVCDLQKRPPETFSQPMHRAMAYVCSFSRVAVSLRRRALQVTGTPQFFDQFDTNNAMGTYRCGAVSDLILGALQCHECQNEMCELRIQRALAPYRFMIAYCPFDEQSLLDLTVFAGTTTTTASNHATAGGQQRGGDQIHPTDEQYANMESRTDPATLTAYDKKDREGSHRHPSPMIAAAPPAQPPSQPQQHYSEGELEEDEDSDDASSQDLVRATDRHGDTVVYKTTAVPPSPPAPLAGVRSHRGELNLMTPSPSHGGSPPQVPHKQPIIPVQSANGNHSTTATQQQQPPPPPPPPPVPQEDDSVVMRCQTPDYEDMLCYSDDMDD
Protein: Nuclear transition protein 2 (TP-2) (TP2) (P11101)
Organism: Rattus norvegicus (Rat)
Function: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10961985, ECO:0000269|PubMed:14514679, ECO:0000269|PubMed:17682055}. Nucleus, nucleolus {ECO:0000269|PubMed:10961985, ECO:0000269|PubMed:14514679}. Chromosome {ECO:0000269|PubMed:14514679}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4 (PubMed:17682055). Nucleolar localization requires the protein to be phosphorylated (PubMed:14514679). {ECO:0000250|UniProtKB:P11378, ECO:0000269|PubMed:14514679, ECO:0000269|PubMed:17682055}.
Interaction partners:
- Spermatid nuclear transition protein 1
- Protamine-2
- Protamine-3
- Sperm protamine P1
- MutS protein homolog 4
Sequence:
MDTKMQSLPTTHPHPHSSSRPQSHTNNQCACSHHCRSCSQAGHPSSSSSPSPGPPTKHPKTPMHSRYSPSRPSHRGSCPKNRKTLEGKVSKRKAVRRRKRTHRAKRRSSGRRYK
Protein: Serine recombinase PinE (EC 3.1.22.-) (EC 6.5.1.-) (DNA-invertase PinE) (DNA-invertase from lambdoid prophage e14) (Site-specific recombinase PinE) (P03014)
Organism: Escherichia coli (strain K12)
Function: This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clear.
Interaction partners:
- Prophage tail fiber assembly protein homolog TfaE
Sequence:
MLIGYVRVSTNDQNTDLQRNALNCAGCELIFEDKISGTKSERPGLKKLLRTLSAGDTLVVWKLDRLGRSMRHLVVLVEELRERGINFRSLTDSIDTSTPMGRFFFHVMGALAEMERELIVERTKAGLETARAQGRIGGRRPKLTPEQWAQAGRLIAAGTPRQKVAIIYDVGVSTLYKRFPAGDK
Protein: Mitochondrial fusion and transport protein ugo1 (Q9UTF8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for mitochondrial fusion as well as normal mitochondrial morphology. May coordinate fusion of inner and outer membranes during mitochondrial fusion (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transmembrane GTPase fzo1
- Mitochondrial fission 1 protein
- Mitochondrial import inner membrane translocase subunit tim23
- Dynamin-related protein dnm1
- Mitochondrial import receptor subunit tom20
Sequence:
MNPYRPYVVVNNVEPTFSITPEPTFETQPTISKSEIFETLRSILVTKYLTTFFVQPLEVAKTVCQVEEYLPKRTKIERDGKQTKEPYDEDIPDGTEQEGLSDDEHEIYAYFETPTTEKAVTEQLAEKLCVDASGYVTDPSNLIERSYTIHSKRFSIKSIISELWEKEGARGLWKGHTISFLHNLLYSGLQSWLSATLSGALAIADPNIISPIDSVRPLLSLFIKSITSAISALILSPLDIARTKIILFPISSSSYLSSASETSGNSHKKFKPLTIRQCLKALPFYCPSSLILPTVCYVSLPPFVSSVLPLTFRNFLGSSPTLDAMVGLGTSAVQFLLKCPLEMVLRRAQAQYECNLPPQTIVPVGKYTGIVGTIWCLLSEEDPGKFGIEGLYRGWRVGIWGMSSTLALNYISSNLREEVEF
Protein: STEAP family member 1B (Q6NZ63)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MESRKDITNQEEIWKMKPRRNLEDNDYLQTAHADEFDCPSELQHAQELFPQWHLPIKIAAVMASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQVHNGTKYKKFPHWLDKWMLTRKQFGLLSLFFAVLHAIYTLSYAMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQVHGRINFLTL
Protein: Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) (Q99801)
Organism: Homo sapiens (Human)
Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288}.
Interaction partners:
- Androgen receptor
- RAC-gamma serine/threonine-protein kinase
- RAC-alpha serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- SAM pointed domain-containing Ets transcription factor
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Prostate-specific antigen
- Beta-microseminoprotein
- Transmembrane protease serine 2
- Kallikrein-2
Sequence:
MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGGRTSSQRQRDPEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSYLLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYPYYPYLYCVGSWSPAFW
Protein: Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3) (ERF2) (Polypeptide release factor 3) (Translation release factor 3) (Q7LKB1)
Organism: Saccharomyces cerevisiae (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSDSNQGNNQQNYQQYSQNGNQQQGNNRYQGYQAYNAQAQPAGGYYQNYQGYSGYQQGGYQQYNPDAGYQQQYNPQGGYQQYNPQGGYQQQFNPQGGRGNYKNFNYNNNLQGYQAGFQPQSQGMSLNDFQKQQKQAAPKPKKTLKLVSSSGIKLANATKKVDTKPAESDKKEEEKSAETKEPTKEPTKVEEPVKKEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIKEQEEEVDDEVVNDMFGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLDTMNHVDRHINAPFMLPIAAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETENEVDMAMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYPQLGRFTLRDQGTTIAIGKIVKIAE
Protein: Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (Q9Y6R4)
Organism: Homo sapiens (Human)
Function: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
Interaction partners:
- Growth arrest and DNA damage-inducible protein GADD45 alpha
- Growth arrest and DNA damage-inducible protein GADD45 beta
- Growth arrest and DNA damage-inducible protein GADD45 gamma
- Dual specificity mitogen-activated protein kinase kinase 3
- Dual specificity mitogen-activated protein kinase kinase 6
- Cell division control protein 42 homolog
- Dual specificity mitogen-activated protein kinase kinase 4
- G-protein coupled receptor 68
- Probable G-protein coupled receptor 132
- G-prodeshotein coupled receptor 4
Sequence:
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
Protein: Putative metabolite transport protein YdjK (P76230)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjJ
- Uncharacterized protein YdjI
- Uncharacterized sugar kinase YdjH
- Uncharacterized HTH-type transcriptional regulator YdjF
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL
- NADH-specific methylglyoxal reductase
- Probable ABC transporter permease protein YphD
- Putative cation transport regulator ChaB
Sequence:
MEQITKPHCGARLDRLPDCRWHSSMFAIVAFGLLVCWSNAVGGLILAQLKALGWTDNSTTATFSAITTAGMFLGALVGGIIGDKTGRRNAFILYEAIHIASMVVGAFSPNMDFLIACRFVMGVGLGALLVTLFAGFTEYMPGRNRGTWSSRVSFIGNWSYPLCSLIAMGLTPLISAEWNWRVQLLIPAILSLIATALAWRYFPESPRWLESRGRYQEAEKVMRSIEEGVIRQTGKPLPPVVIADDGKAPQAVPYSALLTGVLLKRVILGSCVLIAMNVVQYTLINWLPTIFMTQGINLKDSIVLNTMSMFGAPFGIFIAMLVMDKIPRKTMGVGLLILIAVLGYIYSLQTSMLLITLIGFFLITFVYMYVCYASAVYVPEIWPTEAKLRGSGLANAVGRISGIAAPYAVAVLLSSYGVTGVFILLGAVSIIVAIAIATIGIETKGVSVESLSIDAVANK
Protein: Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) (Q9QYM2)
Organism: Rattus norvegicus (Rat)
Function: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q86W56}. Note=Colocalizes with PCNA at replication foci. Relocalizes to the cytoplasm in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q86W56}.
Interaction partners:
- Poly
- Poly [ADP-ribose] polymerase 1
- ADP-ribose glycohydrolase MACROD1
- Poly [ADP-ribose] polymerase
- RLF zinc finger
- DNA repair protein XRCC1
- DNA polymerase beta
- ADP-ribosylhydrolase ARH3
- Histone PARylation factor 1
- Proliferating cell nuclear antigen
Sequence:
MSAGPGCEPCTKRPRWGAAGTSAPTASDSRSFPGRQKRVLDPKDAPVQFRVPPSSSACVSGRAGPHRGSVTSFVFKQKPITTWMDTKGPKTAESESKENNNTRTDPMMSSVQKDNFYPHKVEKLGNVPQLNLDKSPTEKSTPYLNQQQTAGVCKWHSAGERAEQLSASEPSAVTQAPKQLSNANIDQSPPTDGHSDTDHEEDRDNQQFLTPVKLANAKQTVGDGQARSNCKCSASCQCGQDCAGCQREEADVIPESPLSDVGAEDIGTGSKNDNKLTGQESGLGDSPPFEKESEPESPMDVDNSKTSCQDSEADEEASPVFDEQDDQDDRSSQTANKLSSRQAREVDGDLRKRYLTKGSEIRLHFQFEGGSNAGTSDLNAKPSGNSSSLNVDGRSSKQHGKRDSKITDHFVRIPKSEDKRKEQCEVRHQRAERKIPKYVPPNLPPDKKWLGTPIEEMRKMPRCGVRLPLLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCDKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRCCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPPENLSAVATGNWGCGAFGGDARLKALIQLLAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLNVGKVYRLLLRYYREECRDCSSPGPDTKLYPFIYHAAESSAETSDQPGQRTGT
Protein: RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3) (Q86SE5)
Organism: Homo sapiens (Human)
Interaction partners:
- Pre-mRNA-splicing factor RBM22
- RNA-binding protein Raly
- Heterogeneous nuclear ribonucleoprotein C-like 1
- Heterogeneous nuclear ribonucleoprotein C-like 2
- Pre-mRNA-splicing factor SYF1
- Olfactory receptor 52N5
- Peptidyl-prolyl cis-trans isomerase E
- Tigger transposable element-derived protein 3
Sequence:
MTGKTQTSNVTNKNDPKSINSRVFIGNLNTAIVKKVDIEAIFSKYGKIVGCSVHKGYAFVQYMSERHARAAVAGENARVIAGQPLDINMAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEESLVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK