wanglab/gogpt-training-data huggingface dataset:
Protein: Aminopeptidase (EC 3.4.11.-) (B0BCY9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVQAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
Protein: GEO10373p1 (Q9W4M5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- MIP13722p
- Chorion protein a at 7F, isoform A
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- IP19013p
- Mucin 4B, isoform B
- FI16876p1
- IP19005p
- RE05851p
Sequence:
MTAFNRDHHFAFLMIVALVGSSCILGFSDAQTFTAEDRSSIQKFMDSLLNFLELEISNITTTLPPTSNGTTLETTTLAPGNSTEVTTEVSQTSTNSTSSALDTTTSSLNSTTEDSENTTATTTTEANPTTMRRRICFKRFCYKFSNDKGYIV
Protein: Cdc42-interacting protein 4, isoform H (M9ND42)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLALLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKQRQIIEACITMKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: Amino acid transporter, putative (Q57UX9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLSPTEPLGSGKAHTEVVTDEGEGYGAMSAADEKSHHKNGDTPTTDSKFMQCINAIIPHGGALSTTFNLGSATLGAGVISLAIAFQMSGVIPSILILITVTVLTIYSVGLMMQAVEMTGYNSYADLSRNLFGPGWDYFTISVSWLFTFGTCVSYVIATGYLVDSVLSGSSALEFFQGKTGNRVITSIIWFVGMFSLSLPKEINSLRYASAIAVLFVFYFVICIVVHSAKNGLKDGKLPEDVEMFKSGNRAIEGLSIFMFSYLCHMNCFSIYSEMRKPSARRMTLHTTYSMSMCCVVYIIAGFFGYTDVGNKSVETVFEIYDVKGDVMMAIAFAGMLLKICVGFSLCMQPARDCCYYIIGWDLNTLETWKNCLFCGSMALCALLLGLFIPDLNTVFGLLGSFCGGVLGFCIPALYRMYCGNWGISQVGVVNYVCTYLLLISGVIAVVFGTAASIYNVAV
Protein: LYT1p (Q57XD0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAVSGSESGTSEGKLSISSGTSSHNSFSSSSSPSTEGGIQADEPAAETGTSSKSSAAGVSPAADCTNGLEAEYALRRISVGSHKKIDAGEAEMHGKGENQVGGSNQLLKDSPCVHVSRRAEEPKVQGGQPRGRREKQQGPTNENTNSGPGSADAASRLRFLEEMLLHMTALNKELEMDLTKTKKELREYKQAFQRSHSRTAYETPTQSVNARNVDSEWGEIRSRDALYPVARTREAQRRQCHVDPHSDIRGSRAASSRPSAHRRAGADGRLEKRISSSAFGTCPPKGVGSTRVTKEAVSGRELSRGRSGAVNGLLRHPSAQRRYSTAPTVEARPSGVMSRGEHSRQCGQVRDYSQDCRDAHGRKSEPRRENSGPCAGRRKSRSPQPIQRDPSNHRKAPRRSPGSAPQPPSGTQTVKLRGARPTGSVAGPCSRSRSAPKQSTEVVSIPAPLPRNHRNASATATVAPGRGRSSRNFSHAVATAGKPTSKHAASGRAVPRSVESTLTQTQTVTPAPEGNIEDVAALQRRYWQQSRDILEQLNRLLEED
Protein: PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) (O70209)
Organism: Mus musculus (Mouse)
Function: May play a role in the organization of actin filament arrays within muscle cells.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Localizes to myofiber Z-lines. {ECO:0000250}.
Interaction partners:
- Alpha-actinin-2
- Titin
- Smoothelin-like protein 1
- LIM domain-binding protein 3
- Myomesin-1
- Tropomyosin beta chain
- Actin, alpha skeletal muscle
- Filamin-C
Sequence:
MPQNVVLPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAASYQLCLKIDRAETRLWSPQVSEDGKAHPFKINLEAEPQEFKPIGTAHNRRAQPFVAAANIDDKRQVVSASYNSPIGLYSTSNIQDALHGQLRGLIPGSLQNEPTASVPPQSDVYRMLHDNRDDPAAPRQSGSFRVLQDLVNDGPDDRPAGTRSVRAPVTKVHGGAGSAQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFVEGELYCETHARARTRPPEGYDTVTLYPKA
Protein: SNRPN upstream reading frame protein (Q9Y675)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:10318933}.
Interaction partners:
- Small nuclear ribonucleoprotein-associated protein N
- E3 ubiquitin-protein ligase makorin-3
Sequence:
MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQQQVPVVDFQAELRQAFLAETPRGG
Protein: NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 3) (NADH-plastoquinone oxidoreductase subunit 3) (P0C320)
Organism: Oryza sativa (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01394}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01394}.
Interaction partners:
Sequence:
MFLLHEYDIFWAFLIIASLIPILAFWISALLAPVREGPEKLSSYESGIEPMGGAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGISVFIEAFIFVLILVVGLVYAWRKGALEWS
Protein: NIMA interactive protein (C8VK89)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
- Uncharacterized protein
Sequence:
MEQQGDLQAASNYINNVLLARGLVKSGRPIDFANPENEEGGVATTMARIINLVNDLVLRRDREAEHRENLATTIRTLRAEESHKAVEMEKLQTKKSELSRSLALAEAQERALKTSMSSAEATIRGLKDQVQRMKTTVQQVRSQCANDIRKRDLELQKLKAHLADRQRGKRDGLGVTTININPAASQSSRRYLSGGEGVHDPGYSLKQETNEFLTQLLQNLSDENDSLISLARNTVFTLKELQGLSSTEEPAVDNGYLQGSASTAQRSTYGGAAVTSLPASCEELSGEMDQVLEHLRTLLTNPSFVPLEEVEVRDEEIKRLREGWEKMESRWRQAVTMMDGWHKRIAHGGGSVRAEELRMGLKLNDHVDPRYSQVRDNDVAMPSPIFEDQEDEEDEYFGVEATETEPNDDAEPAPDEPQETSSRALKERTDNTASAKHPPRKEVSFTEKDRKSPSKKQQEDDTMPIKAHQSDAVTRRPSRKRVEPKGPRPAPTRMSVPQKLAAAESEARAAEKARQEQESRKRSRGSKVARKKTGDRRRSTLTSDELGELLGMK
Protein: Beta actin (Q28937)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWI
Protein: Solute carrier family 34 member 1 (D6RCE5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLT
Protein: Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) (Q9BY43)
Organism: Homo sapiens (Human)
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan.
Subcellular location: Cytoplasmic vesicle membrane. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Interaction partners:
- Charged multivesicular body protein 2a
- Charged multivesicular body protein 3
- RNF103-CHMP3 readthrough
- Programmed cell death 6-interacting protein
- Charged multivesicular body protein 6
- Tumor susceptibility gene 101 protein
- Charged multivesicular body protein 2b
- Vacuolar protein sorting-associated protein 4A
- Charged multivesicular body protein 7
- Tyrosine-protein phosphatase non-receptor type 23
Sequence:
MSGLGRLFGKGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFGDDVDEDELLEELEELEQEELAQELLNVGDKEEEPSVKLPSVPSTHLPAGPAPKVDEDEEALKQLAEWVS
Protein: Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1) (Q15661)
Organism: Homo sapiens (Human)
Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Subcellular location: Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.
Interaction partners:
- Tryptase beta 2
- Tryptase delta
- Mast cell carboxypeptidase A
- Immunoglobulin heavy variable 3-43D
- High affinity immunoglobulin epsilon receptor subunit beta
- Carboxypeptidase A4
- Chymase
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Protein: Epidermal growth factor receptor substrate 15 homolog (Q54KI4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May be involved in clathrin-mediated endocytosis.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Clathrin heavy chain
- AP-2 complex subunit alpha-2
- Clathrin light chain
- AP-2 complex subunit sigma
- AP-2 complex subunit mu
- I/LWEQ domain-containing protein
- ANTH domain-containing protein
- AP-1 complex subunit beta
Sequence:
MRSEAQVPPAQKVYYEELFQIADVDKDGVIGLNDASFFRNSMLSNDILRDIWQLSDVNNGYLNIDDFFVALKLVSLAQMGAPVTLDSIKLIPVIPPPKLNDIPPLKNDWIISNGEKQNYIDLFNKYDEDGDGFILGSQAKTIFGTSGLPTKMLSHIWNLSDVSKDQKLDCQEFIMATFLIRSVLKGYELPNKLPESLITSSHYISSAGVPSPKIPEWLIPPPERIIYEDLFNKNQQGGIFTGSQAKVLFEKSGLSNQDLKLIWDLADHNQEQVLDKHKFVIAMFLISQRKKGKELPQSLPQLLLESSKSTFNPSSITSPPPQSSPQSSQLQQQPPQQQQQTGDSKYNINLNDLVSNTTPIGQPNIQPTTTTTTTPATASGGLNVSGLLSPPPQQQSPSIVGTPPSTITREGSFTFDNSGGGNNLLAKPPRSNSITRMNSFQHQLPQQQQQQVSPQSTISNTSIGSGSSSFLSTNATTSSPPPIPSTSSQPTSSNNSSITSNNNNPISPTSTNITQLFENIEKVKQQVFEQERIRQEEIQVKLNQELQLEAELKQQLAQEQQQLDEVRENVKEEEIKLSSIKADNQSLKEQISTARVDIKSLKSQLEQQSSLLREKSELFDEQNEALSHLNDDLKEKQQELQKNKQQIEQLLSSIESIKQNRTDVKNQISTVTKQLNDSKLELKQLAEEQKQQKQKLAEEQKQLQQLQQQQQQQATSKSLTSVKSDDNITFLSGINTNTTSTNTATSIPTASVSGNDNWDFFNSPPVKSSSSLPTSPFDDDKTFVPTFTTTTTTTNNNNNNNTINTSNGNLTFTSPVKSTVNQLKSSNSSVGGTGGSVSTRKLSGASVSSNNSFNDNTSIDTLNNHFGSDQFSFNSFGSNNLTAPPTTSSSTNKVQSDFFGVGGGNKDPFGGDSNNNPFGEESTSSIRDGGSETLSEAHTLFDKDPLFETNDAFQSSKDPFGQILFSNFTKDSFGGESVSNNSNNSSIISSNTIPSSNFTFNTNSTTTNNRQSPIDSDLFSDNQQQQQQQQQQQQQQQQQQQQQQQPTQSNQNNQSFTSNDSFDDFQTTPTPTNNNNNTTTTEFGVKFSDTTFGDSSNGDFDFGSNVFGQPSANDPFSSSIEPQHQPDTNNVSSDPFKGGFDDFGSAPFSFDNKFNEVVGDDSPSLTTATTTTTNDNDNGTFVFNDNNNNTPSPFDS
Protein: Calmodulin-binding protein 60 G (F4K2R6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P. syringae pv. tomato DC3000, and microbe-associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in basal and systemic acquired resistance to P. syringae and Hyaloperonospora arabidopsidis. Mediates resistance to drought and sensitivity to abscisic acid (ABA), especially for ABA-mediated signaling process that regulates early seedling growth.
Subcellular location: Nucleus {ECO:0000269|PubMed:22466450}.
Interaction partners:
- Isochorismate synthase 1, chloroplastic
- Probable calcium-binding protein CML46
- 4-substituted benzoates-glutamate ligase GH3.12
- Lipase-like PAD4
- Protein EDS1
- Calmodulin-binding transcription activator 3
- Probable flavin-containing monooxygenase 1
- Aminotransferase ALD1, chloroplastic
- Regulatory protein NPR1
- Regulatory protein NPR3
Sequence:
MKIRNSPSFHGGSGYSVFRARNLTFKKVVKKVMRDQSNNQFMIQMENMIRRIVREEIQRSLQPFLSSSCVSMERSRSETPSSRSRLKLCFINSPPSSIFTGSKIEAEDGSPLVIELVDATTNTLVSTGPFSSSRVELVPLNADFTEESWTVEGFNRNILTQREGKRPLLTGDLTVMLKNGVGVITGDIAFSDNSSWTRSRKFRLGAKLTGDGAVEARSEAFGCRDQRGESYKKHHPPCPSDEVWRLEKIAKDGVSATRLAERKILTVKDFRRLYTVNRNELHNIIGAGVSKKTWNTIVSHAMDCVLDETECYIYNANTPGVTLLFNSVYELIRVSFNGNDIQNLDQPILDQLKAEAYQNLNRITAVNDRTFVGHPQRSLQCPQDPGFVVTCSGSQHIDFQGSLDPSSSSMALCHKASSSTVHPDVLMSFDNSSTARFHIDKKFLPTFGNSFKVSELDQVHGKSQTVVTKGCIENNEEDENAFSYHHHDDMTSSWSPGTHQAVETMFLTVSETEEAGMFDVHFANVNLGSPRARWCKVKAAFKVRAAFKEVRRHTTARNPREGL
Protein: 6,7-dimethyl-8-ribityllumazine synthase (O22919)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g66580
- At3g03280
- Uncharacterized protein At5g17350
- HTH-type transcriptional regulator
- Emb|CAB85509.1
- At3g10120
- D-ribose-binding periplasmic protein
- Uncharacterized protein At3g50800
- HTH-type transcriptional regulator
- At1g21010
Sequence:
MGNSLRCCLACVLPCGALDLIRIVHLNGHVDEITSPMTAGEILQANPNHVLSKPCSQGVVRKILILSPESELKRGSIYFLIPDTSMPEKKKTKKRKELRCRKKPLESGNDINSDHVSTNKDLDGHCLTLCEKYLEDVMLSEKMSSAGKENRHRRKHSRSASVSTWRPHLDSITEDLN
Protein: La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) (Q9BRS8)
Organism: Homo sapiens (Human)
Function: Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17383118}. Nucleus {ECO:0000269|PubMed:17383118}. Note=Shuttles between the nucleus and the cytoplasm.
Interaction partners:
- Serine-threonine kinase receptor-associated protein
- La-related protein 4B
- La-related protein 4
Sequence:
MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKPAKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNKLSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYSSDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRGFHGHERSRACV
Protein: Runt related A, isoform D (M9PI08)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein big brother
Sequence:
MHLTTTSSNSTASNANNNNNNTANNNNTSSNNNTTNTNGSSNNNTSGNNNNSSGNNSNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAGGGAGSGGGAGGGAGGNSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLTTNTPNLGSTAGGGAANGGAGSNAGSGAAGSGAGGAGGASSAVGNPAMLGANQNFPGIVNQAQHSAASAYGGGTGVVGGGHGSAAAAAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVTHPGDLTLIGNCGASVRNIEDGNSNRQVAALAAHRGHHNPTDNGGSVWRPYXGQVLWCGSAVL
Protein: Cationic amino acid transporter 2 (CAT-2) (CAT2) (cCAT-2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) (B3TP03)
Organism: Gallus gallus (Chicken)
Function: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P18581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18581}.
Interaction partners:
- Amino acid transporter.
- Amino acid transporter.
- Solute carrier family 15 member 1
- Alpha-mannosidase.
- Amino acid transporter
- Amino acid transporter
- Amino acid transporter
- Amino acid transporter
Sequence:
MLPCGPALTFVRCLVRKKNIKGEGLEDSLCRCLSTLDLIALGVGSTLGAGVYVLAGEVAKSDSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVAVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLGKQISHFFKTYFKMNYPGLAEYPDFFAVFLILLLSGLLSFGVKESAWVNKIFTAINILVLLFVMISGFVKGDVDNWRISEEYLINLSEIAENFSSYKNVTSIYGSGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVVSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFAYVGWGPAKYVVAVGSLCALSTSLLGSMFPLPRIVFAMARDGLLFSFLAKVSKRQAPLLATLTAGVISAIMAFLFDLKALVDIMSIGTLLAYSLVATCVLILRYQPSLTYEQPKYSPEKATLAASKRESAVSESQINMIQESHFSLQTLINPSSLPTEQTATTVNCFVGLLAFLVCGLSALTTYGTHFIANLEPWSICLLATLVVSFIVTILLIQRQPQNQQKVAFMVPLLPFLPSLSILVNIYLMVQLSADTWIRFSIWMALGFIIYFTYGIRHSLEGRHSDGDGDSCSENSGLQEKNPVEEVDEPENANESDKFLARERTSEC
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CQ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MRINTPIQQTMTRRLAPSMLIFIALVCSAMRCEAAGPDQSKNAAELTALCEFIKLTEADMSALSDEEIDTNDLTIMEALNMTLADPNWSKQFSDDASKPTDEPVPCKGKAATDPCKSHWKKWETAKVKAKDNNIRPDKLKLEEVKLTSSYGRSAALQVASLLEEAEKLKKNWETNHKAHVTGLKAAVTTLLNKAAYNVDPVPAQSNHKCNVKVDTSRQKTCELPKAGEAICGALVCICAKGSTQSKDICGDSSTPNLSDWSSGNMKTHYATYDSICKKNKQIKLTAEAITKRLAALKRLYRDVGNAGGRAVILGTKTDDNTCKDHAGTACIDLTKATASTSEASATEIGWEQKLQEAVDKLNAAEQAKAHRDTTQRQITSMRRQVEAIFKQVAIAPAGTLTAATQPGIAPAQPSITTAGPRLCETFNGNESGCTGAECNYDKVKSECKPKAVEGTTGKARTGEATTEKCKGKPEKDCKDGCKWEGTECKDSSFLLKKQFAPIVSDFVDL
Protein: interstitial collagenase (EC 3.4.24.7) (F1QCX8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- TIMP metallopeptidase inhibitor 2b.
Sequence:
MKTCFRLCVFVTLLFSGHSNPIAPLAGGDQDTLAENYLTRLYGLPKQPAQSPSSSGGEKRSSDMSLRLKEMQQFFKLKVTGKLDQETLEVMKKPRCGVPDIKAYSTFPGDYKWKKHQLTYRIENYTLDMSVAEVDDSISRALKVWADVTPLRFTRIYSGTADIMIFFATGDHGDGYPFDGPNGFLAHAYPPYEGVGGDAHFDDDETFSYRSPQYYTLFSVAAHEFGHSLGLGHSRDPGALMYPTYVYRDMDRFILPRDDVNGIQSLYGPNTDVNTDDSKPTPPVTPNTCDPNLVLDAVTMLRGEIMFFKNSFFWRSYPQSPDVELQLIQSFWPEIPDNIDAAFESVIQDKVFLIKGEKVWALYGYDIVQGYPKSLSMFRLRKNVKKIDAVLYKEDSNTILFFANNQVYSYNERMKKMDKGFPKPVQKVFPGMTGKVTAAFQYRGFNYLFSGSKMLEFGSNNKLLRVLNNNYFLPCK
Protein: U6 snRNA-associated Sm-like protein LSm5 (P40089)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM5 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM5, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA. LSM5 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
Subcellular location: Nucleus.
Interaction partners:
- Pre-mRNA-splicing helicase BRR2
- Small nuclear ribonucleoprotein F
- LSM complex subunit LSM6
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- LSM complex subunit LSM7
- Deadenylation-dependent mRNA-decapping factor PAT1
- 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
- Small nuclear ribonucleoprotein G
Sequence:
MSLPEILPLEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVILEDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGGKKTPTEAL
Protein: RNA-binding protein fxr1-A (xFxr1p-A) (P51115)
Organism: Xenopus laevis (African clawed frog)
Function: RNA-binding protein. Binds poly(G) and poly(U) but not poly(A) or poly(C). Regulates somite formation, probably by regulating gene expression.
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q61584}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P51114}. Cytoplasm {ECO:0000250|UniProtKB:Q5BJ56}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments. {ECO:0000250|UniProtKB:Q61584}.
Interaction partners:
Sequence:
MEDMTVEVRGSNGAFYKGFVKDVHEDSLTVVFENNWQPERQVPFDEVRMPPLPDIKKEITEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVTKNSFFKCTVDVPEDLRESCSNENVHKEFKKAVGACRVYFHAETNQLIILSACESTVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLASAFHEEFIVREDLMGLAIGTHGSNIQQARKVPGITAIELDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNETKLPREDGMVPFVFVGTKENIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSSRGTEKEKGYATDESTASSVRGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKEELSDWSLAGEDERESRQQRDSRRRPGGRGRSGSAGRGRGGSRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHNTNRRRRSRRRRTDEDSSLMDGMTESDNASVNENGLDDSEQKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPKETLAKGKKEKVKDVIEEHGPSEKVINGPRASSADKASNPQTASTERNQASCQDGSKQEAIMNGVS