wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium- and chloride-dependent transporter XTRP3A (IMINO-B) (Solute carrier family 6 member 20A) (X transporter protein 3 similar 1) (Q8VDB9)
Organism: Mus musculus (Mouse)
Function: Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:16174864}; Multi-pass membrane protein {ECO:0000269|PubMed:16174864}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000269|PubMed:16174864}.
Interaction partners:
- Angiotensin-converting enzyme 2
- Leucine zipper transcription factor-like protein 1
- FYVE and coiled-coil domain-containing protein 1
Sequence:
MEKARPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTASMPYCVLIIYLVRGLTLHGATNGLMYMFTPKMEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSIINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVALGTFIRNRLKRGGSAPVA
Protein: Vesicle-associated membrane protein 4 (A0A096MJ99)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046280}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00046280}.
Interaction partners:
Sequence:
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKGVLALSMRVPMLSVSQHLDA
Protein: Ribosome biogenesis protein SLX9 homolog (Q9NSI2)
Organism: Homo sapiens (Human)
Function: May be involved in ribosome biogenesis.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P53251}.
Interaction partners:
- RRP12-like protein
- Bystin
- Protein LTV1 homolog
- Pre-rRNA-processing protein TSR1 homolog
- U3 small nucleolar RNA-associated protein 14 homolog A
- RNA-binding protein NOB1
- Small ribosomal subunit protein uS8
- 18S rRNA
- RNA-binding protein PNO1
- Multifunctional methyltransferase subunit TRM112-like protein
Sequence:
MGKVRGLRARVHQAAVRPKGEAAPGPAPPAPEATPPPASAAGKDWAFINTNIFARTKIDPSALVQKLELDVRSVTSVRRGEAGSSARSVPSIRRGAEAKTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSELSRMSAAQRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQMQLEDGGQL
Protein: CG17075 (Q2XXY4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
LKSGPKGAYGVRSETDHIITISTASLTESHSESPAKGVVTPVRKPHSLGSEDSPENIIPGEQAETNKKPLHLCRLSQLVSYQSNIADVQHRKGRRLHGLQLPLHPLQIFGWLVLLLFGVASYWVLIPAFHARIQGPLYGLITGLYLVHIASHLTALLTDPADKELRRVHRNDRIVPEFDRSKHSHVIENGRCHLCNIRTSSNRTKHCSVCNKCVGKFDHHCKWLNHCIGSRNYVAFLMCVVSAVVATLVIVAAVVAQIVFYYIQPDWLSFYWCPTESSHTIESGDFINITLSLSNGTMMLIEQHTSEEDVHQEMWDEEQANMTISTLPTLLENFTAIIEASATRPGISPTNHTETQPVVTGIGLNETIFMFLLGVLGLLAAVSAGLLLHLCFFHIYISFLGLTTYEYIRNHRQAQDAKTKQLLEGAPGVRAPKNGNVHFSASLPEPHNPSKSLPGGQQLYCCSSAPHPSQHSQESVGQTEQSLRLHCCASSREFHQSGQAIYVCSLLEEAVPQIQVEPDTLSSFHCCSSFAASSLQRRVSLAKGSLISAEPRHLRPATYLQYTEQCTLCTFRLRRGSGPGTGSSGAVSSAGGSSSTRTLTSQTGGSSASATAAGNISKHQRWRRKWNCCAAVPDSPDLPNDLLAALTFRESEEAAAAAKLNAQELPLKATTATPTPPRSSRLRYMLRLLGRYRRPRCRHGAHHGIAAKEHQNIGGSAIKQNQIRPLQLQAAGRGYANSTATPTPPASSPSRSSLESSDLSTSTSPSCGNKELMLLPTSVIRDDSVTTYTLTLPPALPPPTRRKMNQTTQELAELAETLGFASNLQHSQHNSQTNSRTLPSFGNVYRRQRRKHFLRTRSPTLSPIHESGLSNPTSPQPLRHHHQNLANSNSNPAKAMSSPMLNRNSGSANSSALLVQNLCSLAGETLRNSASNSSLQSLS
Protein: Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (A0A140VJG1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH
Protein: DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1) (Q9BW61)
Organism: Homo sapiens (Human)
Function: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
Interaction partners:
- Cullin-4A
- DNA damage-binding protein 1
- DET1 homolog
- DDB1- and CUL4-associated factor 15
- Cullin-4B
- DDB1- and CUL4-associated factor 1
- Activating molecule in BECN1-regulated autophagy protein 1
- DNA damage-binding protein 2
- RNA-binding protein 39
- DDB1- and CUL4-associated factor 11
Sequence:
MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT
Protein: AHA1, activator of heat shock protein ATPase homolog 1a (Activator of 90 kDa heat shock protein ATPase homolog 1a isoform X1) (Ahsa1 protein) (Q29RB9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAKWGEGDPRWIVEERADATNVNNWHWTERDVTSWSQDAINGLLLGIRVEGEEGTCEITDVSNIDGEASINNRKGKLIYFYEWVVKASWTGTNKIGIKYKGIVEIPNLSDENDMDDLDISVTLCKDQPNTPLTDLMRREGVKKIRMALGNYVKHLKTEFAQGMILPTENALFQQNQEAKAKVKLDKTQIGSPSTANAPSTGVKIATVSFSLKDTFLTSPEELYRIFITQEMVQAFTHLAAFVDGRCGGKFRLLEGNVHGQFAELIPDKKIAMRWRFASWPAGHAATVILNFVNQGSETELILEAKGVPSNEEERMKEGWQRYYFNAIKQTFGFGALLY
Protein: Tetraspanin-8 (Tspan-8) (Q8R3G9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P19075}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19075}.
Interaction partners:
- Integrin alpha-4
- Epithelial cell adhesion molecule
- Intercellular adhesion molecule 1
Sequence:
MAGVSSCLKYSMFFFNFLFWVCGTLILGLAIWVRVSKDGKEIITSGDSSTNPFIAVNILIAVGSIIMVLGFLGCCGAVKESRCMLLLFFIGLLLILILQVAAGILGAAFKPEYNRILNETLYENAKLLSDNTDEAKDFQKAMIVFQSEFKCCGLENGAADWGNNFVEAKESCQCTGTDCATYQGSSVYPKTCLSLIKDLFEKNIIIVIGIAFGLAVIEILGLVFSMVLYCQIGSK
Protein: Pathogenesis-related protein 1 (AtPRB1) (Q9ZNS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in the defense reaction of plants against pathogens.
Interaction partners:
- Glucan endo-1,3-beta-glucosidase, acidic isoform
- Regulatory protein NPR1
- Hevein-like preproprotein
- Basic endochitinase B
- Pathogenesis-related protein 5
- Defensin-like protein 16
- Isochorismate synthase 1, chloroplastic
- Lipoxygenase 2, chloroplastic
- Lipoxygenase 4, chloroplastic
- Lipoxygenase 3, chloroplastic
Sequence:
MKVTSYSRILIILAALVGALVVPLKAQDSQQDYVNAHNQARSQIGVGPMQWDEGLAAYARNYANQLKGDCRLVHSRGPYGENLAKSGGDLSGVAAVNLWVNEKANYNYDTNTCNGVCGHYTQVVWRNSVRLGCAKVRCNNGGTIISCNYDPPGNYANQKPY
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (D6RRB7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Stress-activated protein kinase JNK
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
- C-Jun-amino-terminal kinase-interacting protein 2
- C-Jun-amino-terminal kinase-interacting protein 1a
- Mitogen-activated protein kinase 8 interacting protein 1.
- Mitogen-activated protein kinase kinase kinase 7.
- Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
- Sterile alpha motif and leucine zipper-containing kinase AZK.
Sequence:
MSSLEQRLSRIEEKLKQENKEARKRIDLNIDMSPQRTRPRPIIVIQLSPAPAPSQRAALQLPLANDGGSRSSSSESSPQHPSYPNRPRQMLTLPTTPYNLQKNLENAEIDQKLQEIMKQTGYLKIDGQRYPAEVTDLISEGEIGSGTCGQVFKVRFKKTGHVIAVKQMRRTGNKDENKRILMDLDVVLKSHDCPYIIQCYGAIVTNTDVFIAMELMGTCAEKLKKRIQGPIPEAILGKMTVAIVNALLYLKEKHGVIHRDVKPSNILLDAKGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPSKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEDPPVLPLSMGFSPDFQSFVKDCLTKDHRKRPKYHKLLEHSFIRRYEVSEVDVAGWFQAVMERTESPRSSQCFSHHQLHSLFSR
Protein: 3-dehydro-bile acid delta(4,6)-reductase (EC 1.3.1.114) (B0NAQ4)
Organism: Clostridium scindens (strain ATCC 35704 / DSM 5676 / VPI 13733 / 19)
Function: Involved in the secondary bile acid metabolism. Catalyzes two subsequent reductions of the double bonds within the bile acid A/B rings of 3-oxochol-4,6-dien-24-oyl-CoA and 12alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA to yield 3-oxocholan-24-oyl-CoA and 12alpha-hydroxy-3-oxocholan-24-oyl-CoA, respectively.
Interaction partners:
- Hypothetical protein
- L-methionine gamma-lyase
- tRNA dimethylallyltransferase
- DNA mismatch repair protein MutS
- DNA mismatch repair protein MutL
Sequence:
MNRIGIIGGGASGIVAAIAAARSDGDAQVFILEQKENIGKKILATGNGRCNLTNEAMDASCYHGEDPEFARNVLKQFGYGETLEFFASLGLFTKSRGGYIYPRSDQAASVLELLEMELRRQKVKIYTGVRVEALKLSAKGFVIRADGQRFPADRVILACGGKASKSLGSDGSGYALARSMGHTLSPVVPALVQLKVKKHPFAKAAGVRTDAKVAALLGRQVLAEDTGEMQITAYGISGIPVFQISRHIAKGLYEGKEMKVRVDFLPEMEASQVRKAFNTHLDKCPYATCQEFLTGIFPKKLIPRLLELSHIRQNFPASELKPAQWEDLIRACKQTLLTIEDTNGFDNAQVCAGGVRTGEVYPDTLESRYADGLYLTGELLDVEGICGGYNLQWAWATGYLAGRAAAERP
Protein: Formin-C (Q54KF1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12538772}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12538772}. Note=Found localized to the crowns, which are macropinocytotic cups rich in F-actin.
Interaction partners:
Sequence:
MKIRVELINGNEHRTSSTPQQPQQNPSVSHIFDGETAVKDHIKVLLTHFKIPVDKVSSYALQNPFTLAYVEDSFLTPERLVEAEKSYFILRMKPHAIADRVVDQLTKIEPTSPHIKDTIFNIRYQMKDVEYVEEFIIKGGINQLLAVIIKSRGNTQSYALTALRCFMGYNSGLEEVMSRPQLIDKLYSLVCSVGVLPSVCRQAIELLFCVCNFDGFQLVHRSAKNHAQETSTPAYSNLITLLSSGDMETQLNTLTLFNCLLDNAPNPRKSEKLLSRWQQLGIIKILKSQEHVTHSDFRTQIARFQANSGFGIDGSGRKRTLTRQLSTQELEFQLHQFREQQPLISLLTSELKFLRNAIKSAIENGSYINYRAPTERYDEYSQRKLEMIGDSPTNLQFLKRNDKFTNAFRKSMYVRSPNTSDLFDSSTLEDTYDGNNDTNSCTSISTSSTPIHISQPTTLIVPSTTPNHPPQQSQQTPPLQLQKEKEKEKEKEKEKEKEKEKEQQQQQQQSNKQSTPKPNLSCLLSPITISNTLNNNNNNNNNTNNNIIKSNNNNNNNNCTIKDLSPIVKSEKSNEDEIHEISLNGASSNHEEPIKYKLQPTKSPITPSKRMKPLHWTRILNSQFEGKKTIWNSYLPEVTFEEELFVDLFSLYTERIVSFSGSPVGSGTSISGGGPIKSKPIQKVISVLSQKRSNAIIVMCGKLPSDDILIRAIRNLDSNKLSLDGVSSIISNFPTSEELASIHELHSNEVILDKPERWCLMIDGFPMIKHRLRCWEFMLKIEDSLKSIIESIDTVLLACKELRTSITINCLFSLLLQLGNYLNGGHLYRGQSDGFNLESLSKMIEIKDNSNSGSLLDFAIKTLYQQSPMKGNSNTSIHLELAHVPNASLINFTDVGTSVSKLLQDYSEIVLMSDEIQQTTDKDDPFLDIVPKFMGTILLILKNLQTKFLETEKYLFETIDYFNPTNQTLQQYQQQQYQQYQQQQFQQNIINNNNNNNNNNSNNNNNNISGNTTTTTTTTTTTTTGSIINNNNNNNNNNNNSNNNIINNNNSQSNLQSLLHPQYYLSNSSSSSSSSYKITPPLSSSLSITSQEWNQQKFTCEKFFTLFSTITTAFKKSPSKRLSQKGFGLKISNSDDPMAVIIEALKTGSPNDMVKRAF
Protein: Probable phosphatase SPAC5H10.03 (EC 3.1.3.-) (Q09676)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTNNLKKTVYLIRHGQAQHNVGPDEDHNIRDPVLTSEGIEQCEALAKELESKQIPIDGIVCSPMRRTLQTMEIALKKYLAEGGPDKVPVYISPFFQEVGHLPCDIGLELDKLNKLYPKYNFQSCQDGIYPEKRDIYASDVTISAIRSKEALEYLAALPQQQIAVITHSAFIRFLLKKMVKAADIDFLPPQLSFKNCEFRIYDLVQTTTGELKLVESSSA
Protein: ATP-dependent permease PDR10 (P51533)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Oligomycin resistance ATP-dependent permease YOR1
- Transcription factor PDR1
- Transcription factor PDR3
- ATP-dependent permease PDR15
- Pleiotropic ABC efflux transporter of multiple drugs
- Hexose transporter HXT14
- Hexose transporter HXT9
- Hexose transporter HXT11
- Metal resistance protein YCF1
- Inositolphosphotransferase 1
Sequence:
MLQAPSSSNSGLNQGNAAPDGPPNETQPYEGLDAAAQEEIKELARTLTSQSSLLSQEKRITGTGDPNTLTAASSSSLSRSIFASDIKGVNPILLDVNDPDYDETLDPRSENFSSVRWVRNMAQICENDSDFYKPFSLGCAWKDLSASGDSADITYQGTFGNMPIKYLKMSWRCISRRLFHRTHGKSEDNDSGFQILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVNTHGFKISPDTIITYNGFSNKEIKNHYRGEVVYNAESDIHIPHLTVFQTLYTVARLKTPRNRIKGVDRDTFAKHMTEVAMATYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIKALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGYQIFFGPSKQAKKYFQRMGYVCPERQTTADYLTSITSPSERIKDKDMVKHGIMIPQTAYEMNQYWIQSEEYKQLQVQVNKHLDTDSSQQREQIKNAHIAKQSKRARPSSPYTVSFFLQVKYILIRDIWRIKNDPSIQLFTVLSHAAMALILGSMFYEVMLSTTTTTFYYRGAAIFFAILFNAFSSLLEIFSLYETRPITEKHKTYSLYRPSADAFASTFSDVPTKLATAVTFNIPYYFLINLKRDAGAFFFYFLINIITVFAMSHLFRCIGSVSKTLPQAMVPASVLLLAFAMYTGFAIPRVQMLGWSKWISYINPLSYLFESLMINEFHGRNFPCAQYIPSGPNYVNATGDEVTCSALGSIPGNNYVSGDDFIQTNYGYRHKNKWRSVGIGLAYIIFFLFLYLFFCEYNEGAKQNGEMLVFPHSVVKKMKKKGIVSEKKKKNQPTLSTSDAEKDVEMNNNSSATDSRFLRDSDAAIMGNDKTVAKEHYSSPSSSASQSNSFSKSDDIELSKSQAIFHWKNLCYDIPIKNGKRRILDNVDGWVKPGTLTALIGASGAGKTTLLDCLAERTTMGLITGDVFVDGRPRDQSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQADDVSIEEKDKYVEEVIEVLEMKLYADAIVGVPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWSTCQLMKKLASRGQAILCTIHQPSALLMQEFDRLLFLQEGGQTVYFGELGKGCKTMINYFEAHGAHKCPPDANPAEWMLEIVGAAPGTHASQDYFAIWRDSEEYREMQKELDWMERELPKRTEGSSNEEQKEFATSTLYQIKLVSYRLFHQYWRTPFYLWSKFFSTIVSELFIGFTFFKANTSLQGLQNQMLAIFMFTVVFNPILQQYLPLFVQQRELYEARERPSRTFSWKAFIVSQILVEIPWNLLAGTIAFFVYYYPVGFYRNASYANQLHERGALFWLFACAFYVYISSMGVLVISCIEIAENAANLASLFFIMSLSFCGVLATPNILPRFWIFMYRVSPLTYLIDALLSVGLANASVVCSSNELLKIVPPSGMTCSEYMEPYMQSTGTGYLLDGSSETECHFCQFSSTNDYLATVSSSYSRRWMNYGIFSAYIVFDYCAAIFLYWLVRVPKKSKKLKK
Protein: Toucan, isoform A (Q9VQM0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- CENP-meta, isoform C
- CENP-ana, isoform A
- Protein mini spindles
Sequence:
MAKDPATTRIPRLDGVSRLPKPSTFGLASSSGSTTNRTTTTTTSTTQHIRPPTSAPKATQIFRAPGDPAKPRPASSYAPSSAALRDLGSSLKKSASGERINNAVSLLSKRTTTVLKKYFSPKSSASANAVMSSPCDMTSSLPVTPLPVGKRGMVANDQLTSSTPMPLLRSETFVCEDEKQSNRMKLESTRLSTFGRTMDIESPVPNETKVLIRDGTRIMKGSPSTDITQIVRPTQKTPLMTFCSLDTTHEMTVCSRNNATHSVNSSGIMGRTMPVIPAKDATRTISANSSGLGNLTKVVRGVGNINQTLEAAGNITKTFRGAGDLTRTVEKEANIGKTFEVAANCTQTFTRGVNLTRTMNDKNEEVSRTIDKGRSTTKTIEVGQNLTITMDAASNLTKSIDRGATLTNRGANLTKSVIEPGDFTKVIHQGANLTLSMDQLPLLEHISMPSGLDILSSKCSGNVERPSQETDDTLDVTLTSLAPDKTNMKLPLNSTLNTERLLDISALQSPRHIQLLNLTQELERGTPSRVHLQSGRRSMPQHSLLCLSPQSATTTPHGMRMMGQATPQPVHLLSPLLKQAQSALVLPTRTPDGDITMDGNGALDSTLTSTSVRGRTRYSFGLDLPDTTLDCSIELVDNSFSSSTQLQQLQQQLLKKQSSFDLDESLGILTPDQMKDFLDSPHNNLMHNLEMIRMHHPNLLQLRMEQTPSPEELPLDPIEIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSVTSLDTGYQGDGEMSRPASRGACDHSPSNGPHLGRVSRQPSFPPPNPAPLRRQDPMTDSDFFTESDADDVLHRGDRRAQVIDGQLYGPDMMQPSASVPQMEDSCMESSGIFTDVENRCDEEMRQPELEFDVDMDMSPDDSSQTMRKGQGQPISTQQQQNQLAPQQRPPSSCLSSSSAATTLSQSLSNRTSYCSVDGGSARSFCGDEAFAAGRSTTTTAAAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVSSNSSIASPKSCKSSVTKTSAGKSRVLKSPKSPKSPKSPLNRKAHTPNKWDAVMNKIASNKSLIKTNYNDVKSKVSTTRIMTPASGSSPVSGSGSGSVSRTASSPRASPSVSASARRSPSATPKVPPKMLLAKRPSSSSGKVNATPSPPPHATPPTRQPLDKGSVGAGSVGGGGARAVKTPKSPTSPTTPTTPTSPPAKRLQTSLVSRGRSYSKDSHKSSHTDLSLMCNASSSRPSNSASGSGSPKLLANTQLRAAKKRDVRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATPTPTPTSIHKRLNGTLASTAAIATPIKGVATKSGATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKELDAVACKENKHQCARTKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLKFCELESQLRAKDEESKQAQEAYRMEVSHKLALKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVLELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVMKGMIERNDSVSWTLEIEDESFKGNTSKIVRRAGSLRSNNERCPIQRRQTLTSNGHSNGSATNGGSSPAHPNPLSQSMSATALLRSSSNSGESEGRPLSRARSKSMCIKASATSSAVCESSGQRKKPQDELSLADWPEDIPLCSSSPQAPGIEMRPRSSTMKLMSSEAKKFQEIQESAGEAMVSGANSEDESCSASSEDIMRSSSASSTASGGSLSKRPKQPPSRMSIEEALPCTPMEVSWSEDAADANGLA
Protein: Hemoglobin subunit alpha-A (Alpha-A-globin) (Hemoglobin alpha-A chain) (P84790)
Organism: Aythya fuligula (Tufted duck) (Anas fuligula)
Function: Involved in oxygen transport from the lung to the various peripheral tissues.
Interaction partners:
Sequence:
MVLSAADKTNVKGIFSKIGGHAEEYGAETLERMFITYPQTKTYFPHFDLQHGSAQIKAHGKKVAAALVEAVNHIDDIAGALSKLSDLHAQKLRVDPVNFRFLGHCFLVVLAIHHPSALTPEVHASLDKFMCAVGATLTAKYR
Protein: Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) (P97427)
Organism: Mus musculus (Mouse)
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration (By similarity). May participate in cytokinesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14194}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q14194}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q14194}. Cell projection, growth cone {ECO:0000269|PubMed:25358863}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25358863}. Perikaryon {ECO:0000269|PubMed:14685275}. Note=Associated with centrosomes and the mitotic spindle during metaphase (By similarity). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (PubMed:25358863). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (PubMed:25358863). {ECO:0000250|UniProtKB:Q14194, ECO:0000269|PubMed:25358863}.
Interaction partners:
- Dihydropyrimidinase-related protein 3
- Semaphorin-3A
- Plexin-A1
- Dihydropyrimidinase-related protein 2
- Cyclin-dependent kinase 5
- Guanine deaminase
- Plexin-A4
- Uridine 5'-monophosphate synthase
- Sodium channel protein type 9 subunit alpha
- Stress-induced-phosphoprotein 1
Sequence:
MSHQGKKSIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTITAKSHKSTVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSKVFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
Protein: Ferredoxin-2, mitochondrial (Adrenodoxin-like protein) (Ferredoxin-1-like protein) (Q6P4F2)
Organism: Homo sapiens (Human)
Function: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:24281368}. Mitochondrion matrix {ECO:0000250|UniProtKB:P10109}.
Interaction partners:
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- Cysteine desulfurase
- LYR motif-containing protein 4
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- BolA-like protein 3
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
Sequence:
MAASMARGGVSARVLLQAARGTWWNRPGGTSGSGEGVALGTTRKFQATGSRPAGEEDAGGPERPGDVVNVVFVDRSGQRIPVSGRVGDNVLHLAQRHGVDLEGACEASLACSTCHVYVSEDHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGAEFTLPKITRNFYVDGHVPKPH
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q1PE30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAKNRRDRDGGFGVDGLVAVAIDRDKNSQGALKWAVDNLLQKGQTVVLVHVKPRASSLSTNPSINSNSSKTSQINGDSSLVCGEPEGSYKQLFLPFRCLCSRKDIQCKDVLLEESDVARALVEYANQVMIEVLVVGSSSKGGFLRFNKPIDIPGAITKTAPDFCTVYAITKGKLSTKKTASRAAPSVSPLRIQLQQNGLKPHPPLPSATTNTRAERQSFESQHRRSLDDQSDSFRPPYNKRGLTGRSYGELSIPDSEISFNSSGRPSIERNSPSLYDNSDPNRTPPRLSNFSDVDYCSFESMTFGRRSMDLSSPTAFSTGSFENERFSSASQGGDDVEAEMRRLKLELKQTMEMYSTACKEALTAKHKATELQRWKLAEERKFEEAKLAEEAALAIAEKEKAKSKAAMEAAEAAQRIADIESRKRVDAETKALKESEARTKAVNALAKDVRYRKYSIEEIEDATEFFDDKYKIGEGSYGPVYKCYLDHTPVAVKALRPDAAQGRSQFQKEVEVLCSIRHPNMVLLLGACPECGCLVYEFMANGSLEDRLFRQGDSPALSWQTRFRIAAEIGTVLLFLHQTKPEPLVHRDLKPANILLDRNFVSKLADVGLARLVPPSVANTVTQYHMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIMFLQLITGKPPMGLTHYVERALEKGNLKDLLDPAVSDWPVEDTTEFAKLALKCAEIRRKDRPDLSKVILPELNRLRVLAEESTQAAVVINSSGPTPTESQTSSPKL
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (P45894)
Organism: Caenorhabditis elegans
Function: Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress.
Interaction partners:
- CBS domain-containing protein
- 5'-AMP-activated protein kinase subunit beta-1
- Association with the SNF1 complex
- Forkhead box protein O
- DAF-15
- Serine/threonine-protein kinase par-4
- Target of rapamycin homolog
- Ribosomal protein S6 kinase beta
- STE20-related kinase adapter protein strd-1
- CBS domain-containing protein
Sequence:
MPPSGRFDRTIALAGTGHLKIGNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNHMIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYTVPYSMEKQAADLISTMLQVDPVKRADVKRIVNHSWFRIDLPYYLFPECENESSIVDIDVVQSVAEKFDVKEEDVTGALLAEDHHHFLCIAYRLEVNHKRNADESSQKAMEDFWEIGKTMKMGSTSLPVGATTKTNVGRKILEGLKKEQKKLTWNLGIRACLDPVETMKHVFLSLKSVDMEWKVLSMYHIIVRSKPTPINPDPVKVSLQLFALDKKENNKGYLLDFKGLTEDEEAVPPSRCRSRAASVSVTLAKSKSDLNGNSSKVPMSPLSPMSPISPSVNIPKVRVDDADASLKSSLNSSIYMADIENSMESLDEVSTQSSEPEAPIRSQTMEFFATCHIIMQALLAE