wanglab/gogpt-training-data huggingface dataset:
Protein: Peptidase T (EC 3.4.11.4) (Aminotripeptidase) (Tripeptidase) (Tripeptide aminopeptidase) (hTPepTR) (Q84BV2)
Organism: Lactococcus lactis subsp. hordniae
Function: Cleaves the N-terminal amino acid of tripeptides.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00550}.
Interaction partners:
Sequence:
MKYEKLLPRFLEYVKVNTRSDENSTTTPSTQALVEFAHKMGEDMKALGLKDVHYLESNGYVIGTIPANTDKKVRKIGLLAHLDTADFNAEGVNPQILENYDGESVIKLGDTEFTLDPKDFPSLKNYKGQTLVHTDGTTLLGSDDKSGVAEIMTLAEYLLNINPDFEHGEIRVGFGPDEEIGVGADKFDVADFDVDFAYTVDGGPLGELQYETFSAAGAVIEFQGKNVHPGTAKNTMVNALQLAIDYHNALPEFDRPEKTEGREGFFHLLKLDGTPEEARAQYIIRDHEEGKFNERKALMQEIADKMNAEFGQNRVKPVIKDQYYNMAQIIEKDMSIIDIAKKAMENLDIVPIIEPIRGGTDGSKISFMGLPTPNLFAGGENMHGRFEFVSVQTMEKAVDTLLEIIRLNNEVVK
Protein: Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) (O15145)
Organism: Homo sapiens (Human)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079, ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9230079, ECO:0000269|PubMed:9359840}. Nucleus {ECO:0000269|PubMed:29925947}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1A
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
Sequence:
MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ
Protein: DNA replication regulator sld3 (Meiotically up-regulated gene 175 protein) (Q09761)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Plays a role in meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- S-M checkpoint control protein rad4
- Cell division control protein 45 homolog
- DNA replication licensing factor mcm2
- DNA replication complex GINS protein psf2
- DNA replication regulator sld2
- DNA replication licensing factor mcm6
- DNA replication complex GINS protein psf1
- DNA replication complex GINS protein psf3
- DNA replication complex GINS protein sld5
- DNA replication licensing factor mcm4
Sequence:
MNNDHASKKSFCIKAPSNWEKSYLEVWPLVTVPRQCICLRWCISKEYHEFTCSSLQFIVIRPAGTSVLLGRVKSSKANQLVGIEHVEGSRYALIFLSEKLDFKSLKVIANHQLTKSSKSLSNVSNKPLGDQLFRSNSLMSPSLLKKELHRIQSDASQANERESQAPHSFVTHDLISSSKDGNSLTHEFANDSVTEMVQDYTPSCSRDVKSLLDHLYNSYFYQLLMTKTPVVFYVKQMVGKTRQLAVEVHNHVEEKALVDELLKFLDNLKSVDDRKSRLLQCFESHLNYKAWHLEFENEAHQYEIKGYRLWLQNILNRENCQITKLDFEREFSQLKLKEYEIRVLLYFEILYLFLKWDPEYARRRANDNSLLDSRDSGKRKSRKKNAKTLNPFETAQLKLEFTFDGLCIRRTIEQNATERSEDLLLKFCKETIVPYYSSKFPRITRNLLEKCNGLDLLPERSHKHRHSAPPRSKLISSKSEAGRALPGNTSGASISNTSSPHSEASISKDYEILKRRRSNSGVHSLTRSDSSFNGFERDTRRRSSDIARIKNREINLPSSSLSKQRNSMHDISTNFPRRNLSFTEKLTMASLQGQSEESVQPKTTSSLSRSKTLSILEGSVSKRSEPSMDSILVQATPRKSSSVITELPDTPIKMNSLDKASACTVENHIVTESPAHKSNKAQLFVCVPTTPVKKKSASP
Protein: Neuronal migration protein doublecortin (Q9ESI7)
Organism: Rattus norvegicus (Rat)
Function: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration.
Subcellular location: Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:14741102}. Note=Localizes at neurite tips (PubMed:14741102).
Interaction partners:
- Serine/threonine-protein kinase DCLK1
- Nestin
- RNA binding protein fox-1 homolog 3
- Glial fibrillary acidic protein
- Tubulin beta-3 chain
- Neurotrophic factor BDNF precursor form
- Parvalbumin alpha
- Calcium/calmodulin-dependent protein kinase type 1B
- Synapsin-1
- Calretinin
Sequence:
MELDFGHFDERDKASRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLLQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM
Protein: Nitroreductase domain-containing protein (Q57YB2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- Transcription initiation protein, putative
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-direcetd RNA polymerase II, subunit 9, putative
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II, putative
- Spt4/RpoE2 zinc finger domain-containing protein
- Telomerase-associated protein, putative
Sequence:
MRRSVYQLSKELPISEDEVACLVKKVMRECPSAFNSQSSRAVILFGEQHTKLWNLTKDKLKATVKPDSYNEAAKKIDGCFAPAAGTILFLEDKSVVEGLVKSYPAYAEGFPVWSTESSGMAQFAVWTALAEKGIGASLQHYTSLIGEAVTAEWKLPATWEMHAQMPFGKPLEKCGEKTYMPDEERFKVFK
Protein: Uncharacterized protein (Q8CEW7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPRGSRIRTSRVTLLAGRAPQMRAAPRRAPAAQPPAAAAPSAVGSPAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGGSAEPAKPDITYQEPQGAQLQNQQSFGPCSLEIKQFLECAQNQSDVKLCEGFNEVLRQCRIANVDHPRPVDHGERNVKRRKYNEGFLQYGFTSTITVGIERPQCVICGVVLSAESMKPNKLKRHFESKHSSFAGKDTNYFRSKADGLKKARPDTGSKSNKQNVAAVETSYLVALRIARDMKPHTFAAHLLFPVAKDRVRVMIGDEFVTKLSAVSLSNDTVRRRIHDMSADILDQVVQEIKSAPLPICSIQLDESTDVANCLQLMVYVRYINDGDFKDEFLCCKPLERTATALDVFEAVDSFLRQHEISWKSICGVCTDGAPATLGCQSGFQRLVLNESPKAIGAHCMLHLQTLAMKTLPQDFQEVMKSVLSSVNFVKASSLNSRLFLQLCSDLDEPSKTLLLHTEGRWLSRGKVLKRIFELRDELKMFFNQKAIRQFEALFSDNSALQKVAYLVDIFTILNELNLSLQGPNSTCLDLSEKIHSFQMKLQLWQKKIG
Protein: Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha/beta receptor 2) (Type I interferon receptor 2) (O35664)
Organism: Mus musculus (Mouse)
Function: Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305|PubMed:9295335, ECO:0000305|PubMed:9322767}; Single-pass type I membrane protein {ECO:0000305|PubMed:9322767}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305|PubMed:9322767}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:9295335, ECO:0000305|PubMed:9322767}.
Interaction partners:
- Interferon alpha/beta receptor 1
- Interferon beta
- Signal transducer and activator of transcription 1
- Non-receptor tyrosine-protein kinase TYK2
- Signal transducer and activator of transcription 2
- Ubl carboxyl-terminal hydrolase 18
- Tyrosine-protein kinase JAK1
- Interferon epsilon
- Interferon gamma receptor 1
- Ifngr2 protein
Sequence:
MRSRCTVSAVGLLSLCLVVSASLETITPSAFDGYPDEPCTINITIRNSRLILSWELENKSGPPANYTLWYTVMSKDENLTKVKNCSDTTKSSCDVTDKWLEGMESYVVAIVIVHRGDLTVCRCSDYIVPANAPLEPPEFEIVGFTDHINVTMEFPPVTSKIIQEKMKTTPFVIKEQIGDSVRKKHEPKVNNVTGNFTFVLRDLLPKTNYCVSLYFDDDPAIKSPLKCIVLQPGQESGLSESAIVGITTSCLVVMVFVSTIVMLKRIGYICLKDNLPNVLNFRHFLTWIIPERSPSEAIDRLEIIPTNKKKRLWNYDYEDGSDSDEEVPTASVTGYTMHGLTGKPLQQTSDTSASPEDPLHEEDSGAEESDEAGAGAGAEPELPTEAGAGPSEDPTGPYERRKSVLEDSFPREDNSSMDEPGDNIIFNVNLNSVFLRVLHDEDASETLSLEEDTILLDEGPQRTESDLRIAGGDRTQPPLPSLPSQDLWTEDGSSEKSDTSDSDADVGDGYIMR
Protein: BCL2 like 12 (A0A140LIT0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGSEELGLREDTLKVLTAFLKRGEVAGSPVPTPPRSPAQEETTDFLSRLRRCLPCPLGRGAPPTESSRPHFLPLRPCYGSEPESVAASFCSGPASSEFYALVAQRLEQLVQEQLKSPPSSEFQGPPPTEKEALLRRLVALLEEEAEV
Protein: Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) (P63143)
Organism: Mus musculus (Mouse)
Function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (By similarity). Accelerates KCNA4 channel closure (By similarity). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (By similarity). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Enhances KCNB1 and KCNB2 channel activity. Binds NADPH; this is required for efficient down-regulation of potassium channel activity (By similarity). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14722}. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63144}; Cytoplasmic side {ECO:0000250|UniProtKB:P63144}. Cell membrane {ECO:0000250|UniProtKB:Q14722}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14722}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14722}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000250|UniProtKB:Q14722}.
Interaction partners:
- Potassium voltage-gated channel subfamily A member 1
- Potassium voltage-gated channel subfamily A member 2
- Potassium voltage-gated channel subfamily A member 4
- Voltage-gated potassium channel KCNC1
- Potassium voltage-gated channel subfamily A member 6
- Potassium voltage-gated channel subfamily A member 5
- A-type voltage-gated potassium channel KCND2
- Potassium voltage-gated channel subfamily B member 1
- A-type voltage-gated potassium channel KCND3
- Potassium voltage-gated channel subfamily A member 3
Sequence:
MQVSIACTEHNLKSRNGEDRLLSKQSSNAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
Protein: ATP-dependent zinc metalloprotease FTSH 1, chloroplastic (AtFTSH1) (EC 3.4.24.-) (Q39102)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:8910594}; Single-pass membrane protein {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:8910594}; Stromal side {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:8910594}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
- Protease Do-like 1, chloroplastic
- ATP-dependent zinc metalloprotease
- Protease Do-like 8, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- Protease Do-like 2, chloroplastic
- Protease Do-like 5, chloroplastic
- Heat shock 70 kDa protein 4
- Lon protease homolog 4, chloroplastic/mitochondrial
- Chloroplastic ATP-dependent Clp protease proteolytic subunit 1
Sequence:
MASNSLLRSSSNFFLGSHIIISSPTPKTTRKPSFPFSFVSRAKYQITRSSQDENSPNGKPNSPFSSQVALAAILLSSISSSPLALAVVDEPASPSVVIESQAVKPSTPSPLFIQNEILKAPSPKSSDLPEGSQWRYSEFLNAVKKGKVERVRFSKDGSVVQLTAVDNRRASVIVPNDPDLIDILAMNGVDISVSEGESSGNDLFTVIGNLIFPLLAFGGLFLLFRRAQGGPGGGPGGLGGPMDFGRSKSKFQEVPETGVSFADVAGADQAKLELQEVVDFLKNPDKYTALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRVRDLFEKAKSKAPCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATNRPDVLDSALLRPGRFDRQVTVDRPDVAGRVKILQVHSRGKALGKDVDFDKVARRTPGFTGADLQNLMNEAAILAARRELKEISKDEISDALERIIAGPEKKNAVVSEEKKRLVAYHEAGHALVGALMPEYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALGGRVAEEVIFGDENVTTGASNDFMQVSRVARQMIERFGFSKKIGQVAVGGPGGNPFMGQQMSSQKDYSMATADIVDAEVRELVEKAYKRATEIITTHIDILHKLAQLLIEKETVDGEEFMSLFIDGQAELYIS
Protein: Uncharacterized protein (Q57VG3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVVVRVVVRNGSYAARGPYKNRNSCMAFPHVSYRVYSSSTSGALRPSCRVLRPQTIKPNPAHTPSGKFDRSFEKLSSEIENRMPFRQQQILFGSKYDRNFGEESQDELKKAAQDDLFGREPERAAARQARSYFTGDDLSPTALHVKSPRLKVSQLQHRQNYDKNILKTSKEADDYYYRRETPSERGARRRVLYSVASVVGIGACWGTYCLCQYMLE
Protein: Probable cytochrome P450 6d2 (EC 1.14.-.-) (CYPVID2) (Q9W223)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Probable cytochrome P450 304a1
Sequence:
MWTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGKIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPLKLRLTKRK
Protein: Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41) (D3ZKT0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:29253589}; Peripheral membrane protein {ECO:0000269|PubMed:29253589}; Matrix side {ECO:0000250|UniProtKB:P53230}.
Interaction partners:
- Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Cardiolipin synthase
- Phosphatidate cytidylyltransferase 1
- Tafazzin family protein
Sequence:
MALQALHSSGVGLRRILAHFPEDLSLAFAYGSAVYRQAGPSAHQENPMLDLVFTVDDPVAWHAMNLKKNWSHYSLLKLLGPRIISSVQNNYGAGVYFNPLIMCDGKLIKYGVISTGTLIEDLLNWNNLYIAGRLQKPVKIVSMNESTVLRAALDKNLKSAVTTACLMLPESFSEEDLFIEIAGLSYSGDFRMVIGEEKAKVLNIVKPNVVHFRELYESILQKDPQMVYKMHQGQLEIDKSPEGQFTQLMTLPRTLQQHINHIMDPPGRNRDVEETLLQVAQDPDCGDVVRLAVSSIVRPSSIRQSTKGLFTAGVKKSVIYSSRKLNKMWKGWVRKTS
Protein: Histidine kinase 5 (EC 2.7.13.3) (Arabidopsis histidine kinase 5) (AtHK5) (Protein AUTHENTIC HIS-KINASE 5) (Protein CYTOKININ-INDEPENDENT 2) (Q3S4A7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. Negative regulator of the ETR1-dependent abscisic acid (ABA) and ethylene signaling pathway that inhibits the root elongation. Promotes stomatal closure. Regulates stomatal opening by integrating multiple signals via hydrogen peroxide H(2)O(2) homeostasis in guard cells in an ABA-independent manner. May contribute to basal defense mechanisms by closing stomata in the presence of bacterial pathogens. Regulates both hormone levels and ROS production in response to stress. Required for full immunity to bacterial pathogen and necrotrophic fungus.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18560512}; Peripheral membrane protein {ECO:0000269|PubMed:18560512}. Cytoplasm {ECO:0000269|PubMed:18560512}.
Interaction partners:
- Histidine-containing phosphotransfer protein 1
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 5
- Ethylene response sensor 2
- Pseudo histidine-containing phosphotransfer protein 6
- Histidine-containing phosphotransfer protein 4
- Two-component response regulator ARR22
- Two-component response regulator ARR4
- Probable glutamate carboxypeptidase AMP1
- Homologous-pairing protein 2 homolog
Sequence:
MVCEMETDQIEEMDVEVLSSMWPEDVGTEADKQFNVEKPAGDLDTLKEVTIETRTIADMTRLPNLLNSTHQGSSQLTNLVKQWEYMQDNAVRLLKEELKNLDRQREEAEAKELKIIEEYKFESNEPENVPVLDETSDLFRRFRQKKRDALVDSKKIEIYEEFDTVAYWKQKALSLEKMLEASTERERRLMEKLSESLKTMESQSAPVQELTQNLKRAEGFLHFILQNAPIVMGHQDKDLRYLFIYNKYPSLREQDILGKTDVEIFHGGGVKESEDFKREVLEKGKASKREITFTTDLFGSKTFLIYVEPVYNKAGEKIGINYMGMEVTDQVVKREKMAKLREDNAVRKAMESELNKTIHITEETMRAKQMLATMSHEIRSPLSGVVGMAEILSTTKLDKEQRQLLNVMISSGDLVLQLINDILDLSKVESGVMRLEATKFRPREVVKHVLQTAAASLKKSLTLEGNIADDVPIEVVGDVLRIRQILTNLISNAIKFTHEGNVGIKLQVISEPSFVRDNALNADTEEHEQNGLTETSVWICCDVWDTGIGIPENALPCLFKKYMQASADHARKYGGTGLGLAICKQLVELMGGQLTVTSRVSEGSTFTFILPYKVGRSDDYSDDQDEFSDMADQQSEPDDTAEGYFQFKPLLGSIYSNGGPGISNDFLPHKVMLTSPIKLINGFVADPSNNTGQSEMLQLENGGYMDESKLETSSGHCPESAHQYENGNGRCFSKESESCSSSQASSEGGTLEMESELTVSSHREEEKAETEVKETSKPKILLVEDNKINIMVAKSMMKQLGHTMDIANNGVEAITAINSSSYDLVLMDVCMPVLDGLKATRLIRSYEETGNWNAAIEAGVDISTSENEQVCMRPTNRLPIIAMTANTLAESSEECYANGMDSFISKPVTLQKLRECLQQYLH
Protein: Uncharacterized protein Rv1290c (P9WM35)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGWVHAYSVTATSMLNRRKAILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKLMFQGTPGDARGVLIVVSATMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQVVLAIFACTFAYSTGGLHTVGEHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHSIQIDTIMDKVRLRTLGLVDQLYPESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDVDDIAELAAASRYTALLVTFVGDYVTAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIGFERTLQQDIRFGLRQMVDIALRALSPALNDPYTAIQVVHHLSAVESVLASRALPDDVRRDRAGELLFWLPYPSFATYLHVGCAQIRRYGSREPLVLTALLQLLSAVAQNCVDPSRRVAVQTQIALVVRAAQREFADESDRAMVLGAAARATEVVERPGTLAPPPSTFGQVAAAQAAASTIRSADRDG
Protein: Cyclic nucleotide-binding domain-containing protein (Q387J0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIHKLFVTTWMYFFPIESTIILKGNMSFDYAVLSPTEIIIYKERNAPILKKVTNLLLRGGAFGYLNLEKMLHRSTEKDSDDSKKGRRINPVTFKSVMVQCGVLLTPEEHKSLRAAYSDEGGFIVDQFLELVCPLRCLREEQISMLMGMYTDYDSAPMIPLDVLRRTLEEALVARSATPEAGESPVIASALVELQTVFTPSLYPKGYVPPRDVLNFFAAILLNAVGDEESVVDWLSMVRFSPESPHEVAPALPPVLPLTQRRERGFDYYTDRDNKDEWIRGREERPPGEMYKRFLPGYAGHIPTYCSKFGRTFHTIEESAPTLTRPVQKLDPVPEDRYGPGVELKPSRMSRHNFKLA
Protein: Anaphase promoting complex subunit 7, isoform B (Q8IRQ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMRHKNAVLVAIESSYPEFGDAEQRRRAAECYRQIGNTDMAIETLLQVPPTLRSPRINLMLARLQHHGSRHGTTKKSEAVLAYKEVIRECPMALQVIEALLELGVNGNEINSLVMHAATVPDHFDWLSKWIKALAQMFNFKHSDASQTFLMLHDNTTLRCNEHLMMALGKCLYYNGDYFQAEDIFSSTLCANPDNVEAIGLMAVLCGQEGGCEQDSADMDYLFAKVSSEVKYTASHWFAHAQLLYDEGKFERGLNFVEKCLDSEPRNHEALILRGRLLIALERHTQAVCAFRTAQMVAPYRFEIYRGLFHSYLAQKRFKEANALCNWTIRLFQNSPRSFTMFGRTLFLFPDPRMRRTARKFAEKSLKINHIYTPAVNLIADICQVEGPTKAIIKLLEKHVIIFPKVNLLNHLGDIMRKQKEPVKAMEYYYKALRQDPKSKRTLRGLRLLAKSDDESPVLDESDDIGMDNQQSINDLTTLCEATNAQGAEGAESVENSREASSSAAARSGQEEDVDEHDWIDVPDGMSY
Protein: Zinc finger protein 141 (Q15928)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation as a repressor. Plays a role in limb development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- IQ domain-containing protein E
Sequence:
MELLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRKEPYNVKIHKIVARPPAMCSHFTQDHWPVQGIEDSFHKLILRRYEKCGHDNLQLRKGCKSLNECKLQKGGYNEFNECLSTTQSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKECGKSFQKFSHLTQHKVIHAGEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGEKPYKCEECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAKHKRIHTGEKPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNEHKKVHTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSADKPYKCKECDKAFKQFSLLSQHKKIHTVDKPYKCKDCDKAFKRFSHLNKHKKIHT
Protein: Probable G-protein coupled receptor 27 (Super conserved receptor expressed in brain 1) (O54897)
Organism: Mus musculus (Mouse)
Function: Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MANASEPGGGGSGGGAEAAALGLRLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGTPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGADDEDAPCALEQRPDGAPGALGFLLLLAAVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL
Protein: Glycine-rich protein family (Putative glycine-rich protein) (Q9SL14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Thylakoid lumenal 17.9 kDa protein
- DEAD-box ATP-dependent RNA helicase 55
- Bromodomain testis-specific protein
- KIN14B-interacting protein At4g14310
- Membrane related protein-like
Sequence:
MASKALVLFGLFAVLLVVTEVAAASGTVKSESGETVQPDQYNGGHGGNGGYNGGGGYNGGGGHNGGGYNGGGGYNGGGHGGRHGYCRYGCCYRGYHGCSRCCSYAGEAVQTQPGH