wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-related protein Rab-1B (EC 3.6.5.2) (Q9D1G1)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H0U4}. Membrane {ECO:0000250|UniProtKB:Q9H0U4}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H0U4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0U4}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q9H0U4}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H0U4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0U4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P10536}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000250|UniProtKB:Q9H0U4}.
Interaction partners:
- TBC1 domain family member 20
- Ras-related protein Rab-1A
- Trafficking protein particle complex 8
- General vesicular transport factor p115
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 4
- Rab GDP dissociation inhibitor alpha
- Trafficking protein particle complex subunit 3
- Rab GDP dissociation inhibitor beta
- Trafficking protein particle complex subunit 5
Sequence:
MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGVPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPASGGCC
Protein: Protein TOM71 (71 kDa mitochondrial outer membrane protein) (P38825)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in MBF1-mediated mitochondrial morphogenesis.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:16689936, ECO:0000269|PubMed:8612740, ECO:0000269|PubMed:8663394}; Single-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:16689936, ECO:0000269|PubMed:8612740, ECO:0000269|PubMed:8663394}.
Interaction partners:
- Heat shock protein SSA1
- ATP-dependent molecular chaperone HSP82
- ATP-dependent molecular chaperone HSC82
- Membrane-anchored lipid-binding protein LAM6
- Mitochondrial import receptor subunit TOM20
- Heat shock protein SSA2
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM22
- Mitochondrial F-box protein MFB1
- Mitochondrial import receptor subunit TOM7
Sequence:
MAENSLLRFITKNKVAILATVSAGTAAVGAYVYYQQIKQQQQQQLKGTKDNRRQSEAFAGQNEDEADLKDDGSVVSGSNKRKKKKNKRKRNNKAKSGEGFDYPSLPNGEPDIAQLKGLSPSQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNEPVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKVLNENLSKDEGRGSQVLPSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEGYLVANDLLTKSTDMYHSLLSANTVDDPLRENAALALCYTGIFHFLKNNLLDAQVLLQESINLHPTPNSYIFLALTLADKENSQEFFKFFQKAVDLNPEYPPTYYHRGQMYFILQDYKNAKEDFQKAQSLNPENVYPYIQLACLLYKQGKFTESEAFFNETKLKFPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVQEKIHVGIGPLIGKATILARQSSQDPTQLDEEKFNAAIKLLTKACELDPRSEQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAKIQKRLRADPIISAKMELTLARYRAKGML
Protein: POU domain, class 3, transcription factor 4 (Brain-specific homeobox/POU domain protein 4) (Brain-4) (Brn-4) (Octamer-binding protein 9) (Oct-9) (Octamer-binding transcription factor 9) (OTF-9) (RHS2 class III POU protein) (P62516)
Organism: Rattus norvegicus (Rat)
Function: Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MATAASNPYSILSSSSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAPNSSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASTQSLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDASCHDL
Protein: Phage shock protein B (P0AFM9)
Organism: Escherichia coli (strain K12)
Function: The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation.
Subcellular location: Cell inner membrane; Single-pass membrane protein.
Interaction partners:
- Phage shock protein D
- Phage shock protein A
- Phage shock protein C
- Psp operon transcriptional activator
- Phage shock protein G
- Thiosulfate sulfurtransferase PspE
- Aerobic respiration control sensor protein ArcB
- UPF0208 membrane protein YfbV
Sequence:
MSALFLAIPLTIFVLFVLPIWLWLHYSNRSGRSELSQSEQQRLAQLADEAKRMRERIQALESILDAEHPNWRDR
Protein: Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor of activated protein kinase C) (RACK) (O42248)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21262816}.
Interaction partners:
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein eL24
- Ubiquitin-ribosomal protein eL40 fusion protein
- 40S ribosomal protein S12
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein uS9
- Ribosomal protein L15
- Ribosomal protein L26
Sequence:
MTEQMTVRGTLKGHSGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLGVCKYTIQDDSHTEWVSCVRFSPNSSNPIIVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDTINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELRQDIITTNSKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQVTIGTR
Protein: Tropomyosin 1 (H0YKJ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM
Protein: CREB3 regulatory factor (Luman recruitment factor) (LRF) (Q8CDG5)
Organism: Mus musculus (Mouse)
Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Colocalizes with CREB3 in nuclear foci. {ECO:0000250}.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 3
- cAMP-responsive element-binding protein-like 2
- Kelch-like protein 24
Sequence:
MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITNRAAAPVCSSKTLQAEVPSSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVAKRQERRGVEPHQGRGTPALPFKETQELLLSPLTQDSPGLVATAESGSLSASTSVSDSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDEFDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERILRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQDIVNRVQNPREEREPSMGQKLEILIKDTLGLPVAGQTSEFVNQVLGKTAEGNPTGGLVGLRIPASKV
Protein: Sulfhydryl oxidase 1 (EC 1.8.3.2) (Quiescin-sulfhydryl oxidase 1) (AtQSOX1) (Q8W4J3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sulfhydryl oxidase involved in the regulation of cation homeostasis. Positively regulates shoot accumulation of K(+) and inhibits accumulation of toxic cations. Acts at the level of root K(+) efflux systems involved in xylem loading (root symplast-xylem interface).
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:17568770}. Note=Associated with the cell wall.
Interaction partners:
- Endoplasmic reticulum oxidoreductin-1
- FAD-linked sulfhydryl oxidase ERV1
- Thiol-disulfide oxidoreductase LTO1
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitochondrial import inner membrane translocase subunit TIM9
Sequence:
MSLIHLFLLLGLLSLEAAASFSPGSRSILRDIGSNVADQKDNAIELNATNFDSVFQDSPAKYAVLEFFAHWCPACRNYKPHYEKVARLFNGADAVYPGVVLMTRVDCAIKMNVKLCDKFSINHYPMLFWAPPKRFVGGSWGPKQEKNEISVVNEWRTADLLLNWINKQIGSSYGLDDQKLGNLLSNISDQEQISQAIFDIEEATEEAFDIILAHKAIKSSETSASFIRFLQLLVAHHPSRRCRTGSAEILVNFDDICPSGECSYDQESGAKDSLRNFHICGKDVPRGYYRFCRGSKNETRGFSCGLWVLMHSLSVRIEDGESQFAFTAICDFINNFFMCDDCRRHFHDMCLSVKTPFKKARDIALWLWSTHNKVNERLKKDEDSLGTGDPKFPKMIWPPKQLCPSCYLSSTEKNIDWDHDQVYKFLKKYYGQKLVSVYKKNGESVSKEEVIAAAEEMAVPTNALVVPVGAALAIALASCAFGALACYWRTQQKNRKYNYNPHYLKRYNSNYMVMNTFSNTESEREKER
Protein: Protein sum2 (Q9HGL3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for G2/M phase checkpoint control.
Interaction partners:
- Putative ATP-dependent RNA helicase ste13
- Enhancer of mRNA-decapping protein 3
- mRNA decapping complex subunit 2
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Deadenylation-dependent mRNA-decapping factor pdc2
- mRNA-decapping enzyme subunit 1
- 5'-3' exoribonuclease 1
- Uncharacterized protein C12G12.07c
- Probable 1-aminocyclopropane-1-carboxylate deaminase
- Putative formamidase C869.04
Sequence:
MTEFIGSRISLISKSDIRYVGILQDINSQDSTLALKHVRWCGTEGRKQDPSQEIPPSDNVFDYIVFRGSDVKDLRIEEPATTPSAPPVQPPNDPAIIGSNSGQYNWNQAQTAQPPQPVQPNPYGAPYQQAPPAGAPYYMYPNAPAQFVPPGGLPLGTPLDASTPAVPYYGAPDQQQMGQRPEFAQNVSQGFAGQAPYNVRPGYGMPSNQKPPNFAPGMPAPGPTAVSASPSLQSMPPTNGVIPGAQPSIEASIEKESTSIRNSTVTNDRVVNTTVDVSQSQTVETSGPSKEVPTTQPDASAAKPRTEFDFQTANQKFQSMKDDLLKGKNDEEAEEFYKPKQSFFDNISCESKEKGMEAADRRALRDRERSLNMETFGVAGSGNRGRRGRGRGRGGRGRGRGYARNQYNQYRNSNGSQPRAQPANDQ
Protein: Cation/H+ antiporter (C6KSN3)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Calcineurin subunit B
- E1-E2 ATPase, putative
Sequence:
MVMGRVRATSYVRRTISQPLNKNVPPMKNMKNVNGLKDTNLIRNRNLHLQLLCNNKMPAGMYDDELTKVYDLEETLPFYYPRKSDIYGMQNMLNSKLNVLLIFVPIGLLSHFFGFKDIYIFFFNFMVLIPLSALMGHVTEDLALHTGEIIGGLLNATFGNLMEMIFSIQALNAGLINVVQGTLLGSILSNLLLVLGMSFFAGGLYHHIQKFNEKGATCSTSLLLLSSLAITIPTVSSFTTNNNLDVILKVSRITAVLIFVTYCLFLLFQLYTHISLFQDKEMTEEIPQLSVISGSIFLILITLLVSIHSEFLIYSIDSVIKYYNISENFIGVILLPVVGNATEHLTAVTVAMKNKVDLTMGVAVGSSAQIALFVVPVTVLFGWILNKPMTLAFSPLSTVILVISVIVTMAIVQDGESNWLEGVLLISAYLIVGVVFWFDTS
Protein: LP05220p (Secretory 24CD, isoform A) (Secretory 24CD, isoform B) (Q9VQ94)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004397}.
Interaction partners:
Sequence:
MNPNMYGPPPTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSAASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPETPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS
Protein: AP-1-like transcription factor YAP5 (P40574)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcriptional activator HAP5
- Protein CCC1
- Transcriptional activator HAP3
- Iron-regulated transcriptional activator AFT1
- Protein GAT3
- Transcriptional activator HAP2
- Iron-regulated transcriptional activator AFT2
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
- Transcriptional activator of sulfur metabolism MET28
- mRNA decay factor CTH2
Sequence:
MALPLIKPKESEESHLALLSKIHVSKNWKLPPRLPHRAAQRRKRVHRLHEDYETEENDEELQKKKRQNRDAQRAYRERKNNKLQVLEETIESLSKVVKNYETKLNRLQNELQAKESENHALKQKLETLTLKQASVPAQDPILQNLIENFKPMKAIPIKYNTAIKRHQHSTELPSSVKCGFCNDNTTCVCKELETDHRKSDDGVATEQKDMSMPHAECNNKDNPNGLCSNCTNIDKSCIDIRSIIH
Protein: Uncharacterized protein (Q380Y7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DUF4201 domain-containing protein
- Amidinotransferase
- Kinesin-like protein
Sequence:
MSASAIRRAGPFSNVKPSGLVMNRKDIRSARELTQANYATEYLYLRENELTDFDIDITMEHLRVLDLSINEIGSVDFLRKTPYLRHLYLSGNKIEHLHGISNFSSLETLCLSDNAINSFEGLEKLPNLRVLSLNFNKISSFKHYGKFPSLHTLNLVGNPLTEVPSYRSMAIAINNSNLVSIDGHPVTAEERAALEHYQGKIGYCIADGFVVDGDNVEESADAFLLKLQRAREKSKCLQLCSIRLVPDDESRNVLTEGVPVRLSCCMQDVRSYEQRTEDIFHSRYLYPVTFKVSGEATEVFVVGSMNNWADPIELERCEEEGEIYFHTTLYLPAGDYEYRYIVDGVEIVPESNGVLSKHKQGYCYLYKVTELTQSDDEKDTILHIRWMRSTQNNFYEVIEDNNTLTYTPTVSDVGCCLRAEVLAYIDGVFSFLYFDISAPIVAGPPTCPHLEIKGKATEGHVLLAEADYSGGIEGNSSLNWFRITPDNEEISIDVNDPWAGYKLTSKDVDCRIKVEFTPMRNDWVAGEPKSAITGPVAAGPPECESIKIIGNLIQESDLEVEVVYSGGTEGESYYQWLRKDDNSEEYFPIEGENSTRYVPTLEDVGKCLAVEYTPVNKLGEEGKTCLCVLEKPIEPSPPEIRDLRITGELVEQHVLTLEYQYTGGHAGAHMIQWFRRDRQDRRAKVGRPNTATLALTRREVDCTIEVTVTPVRFDGVQGRAVRATSECAVSAGIPQTNFLNVVGDPVVGSTLELEVEYFGGEAGEPIIEWAREVPLTEEFEVIDTGVRTYRVQEEDQGKMIRVTYTPVRKDGMQGEAKSRIVQVPHGDDGGETTRLRGADDLHVDPASLNAADAVTTAEIAAAELGAAGGEEDAEKPTDAAADEDAEKSTEAAADEDAEKSTEAAADEGAEKSTEAAADEGAEKSTEAAADEGAEKSTEAAADEDAEKPTDANPSAEAAVRLDASSTDETSTSAPAPMPGAAQALAAALNSVTSSAASTTRTDGA
Protein: Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form] (Q9UQC9)
Organism: Homo sapiens (Human)
Function: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; SUBCELLULAR LOCATION: [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
Interaction partners:
- Anoctamin-2
- Anoctamin-1
- Calcium-activated chloride channel regulator 4
- Calcium-activated chloride channel regulator 1
- Cystic fibrosis transmembrane conductance regulator
Sequence:
MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISNIKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAHGDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNNDKPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASIMFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPPTFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEIRAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTSGDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAFSRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIILFDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNSAVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDGAGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGNIQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL
Protein: J domain-containing protein 1 (Q12350)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable chaperone.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial DnaJ homolog 2
- ER-localized J domain-containing protein 5
- Mitochondrial import inner membrane translocase subunit TIM14
- DnaJ protein homolog XDJ1
- Protein CAJ1
- J domain-containing protein APJ1
- Auxilin-like clathrin uncoating factor SWA2
- Pre-mRNA-splicing factor CWC23
- J protein JJJ1
- J-type co-chaperone JAC1, mitochondrial
Sequence:
MLHHKFVYPFLFKWHLSCVEKCPPQITFIAKYATANDKNGNRKLTIRDEQWPELADPTPYDIFGIPKAGSGNPKLDKKSLKKKYHRYVKLYHPDHSDNIQIFSSEKVTNSDSKSPLLLTSSEKLHRFKVISQAYDILCDPKKKIVYDTTRQGWTTSYSPRSNVNTENYQYAGSYGYHSNAQYEYWNAGTWEDANSMKNERIQENINPWTVIGIICGLAICIEGTALLAKIQESLSKAEFTHDESGLHLIQSYTNYGLDTDKFSRLRRFLWFRTWGLYKSKEDLDREAKINEEMIRKLKAAK
Protein: EXS (ERD1/XPR1/SYG1) family protein (Q8VYS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Probable E3 ubiquitin-protein ligase RHG1A
- Berberine bridge enzyme-like 5
- Protein RESPONSE TO ABA AND SALT 1
- Pre-mRNA-splicing factor
Sequence:
MFENPASNSPHLRKSSSKSVFIDPGLNGHLGEMGDLKGSNSPLHITTMVPSPIFLWRFKVVLFLFWALCCCKIGWDSVMRMSIDLRDLFLYEAFLYYNPLLLVTMMVWLWGVNLWVFSQGSVNYSKVFDLDHNHLTHREMWKCSMWMTIIVPTSMTAYLYLYSHGEVSLAASQPVLLYIAFALVLIFPFDIFYLSSRYFLLRTLWRIAFPLQPITFPDFFLADILTSMVKVFSDLERSVCRMVHRQVATIAWFEADAVCGSHQIAIPLVLVFPYICRLLQCLRQYKDTKEKSSLLNALKYSTAVPVIFLSALKYHVMPESWTSFYRPLWLFSSVINSLYSFYWDVTRDWDLSGFTKIFKFSRPSTISNLLYGRQWVYFWVIGSNLVLRCAWTYKLSAHLRHNYITVFTMTAMEMLRRFQWVFFRVENEWNKITKSHPMGEISLEEDKLLGSTTPHDV
Protein: Structural maintenance of chromosomes protein 5 (Q08204)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular location: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Interaction partners:
- Structural maintenance of chromosomes protein 6
- Non-structural maintenance of chromosomes element 1
- Non-structural maintenance of chromosome element 4
- Non-structural maintenance of chromosome element 3
- DNA repair protein KRE29
- E3 SUMO-protein ligase MMS21
- Non-structural maintenance of chromosome element 5
- ATP-dependent DNA helicase MPH1
- Regulator of Ty1 transposition protein 107
- ATP-dependent helicase SGS1
Sequence:
MTSLIDLGRYVERTHHGEDTEPRSKRVKIAKPDLSSFQPGSIIKIRLQDFVTYTLTEFNLSPSLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIGRSKKVEDFIKNGQDVSKIEITLKNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLINDYQVSESVVKTLVAQLNIQLDNLCQFLSQERVEEFARLKSVKLLVETIRSIDASLLDVLDELRELQGNEQSLQKDLDFKKAKIVHLRQESDKLRKSVESLRDFQNKKGEIELHSQLLPYVKVKDHKEKLNIYKEEYERAKANLRAILKDKKPFANTKKTLENQVEELTEKCSLKTDEFLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQATIISTKEDFLRSQEILAQTHLPEKSVFEDIDIKRKEIINKEGEIRDLISEIDAKANAINHEMRSIQRQAESKTKSLTTTDKIGILNQDQDLKEVRDAVLMVREHPEMKDKILEPPIMTVSAINAQFAAYLAQCVDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADTTPPVPAETVRDLGFEGYLSDFITGDKRVMKMLCQTSKIHTIPVSRRELTPAQIKKLITPRPNGKILFKRIIHGNRLVDIKQSAYGSKQVFPTDVSIKQTNFYQGSIMSNEQKIRIENEIINLKNEYNDRKSTLDALSNQKSGYRHELSELASKNDDINREAHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLKQRHLLSKMASSMKSLKNCQKELISTQILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKKKFVKEMRDTPEFQSWMREIRSYDQDTKEKLNKVAEKYEEEGNFNLSFVQDVLDKLESEIAMVNHDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKEDHAVLEPKLDDIVSKISARFARLFNNVGSAGAVRLEKPKDYAEWKIEIMVKFRDNAPLKKLDSHTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAENTSQYFLITPKLLTGLHYHEKMRIHCVMAGSWIPNPSEDPKMIHFGETSNYSFD
Protein: Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST 12-12) (GST class-theta-2) (Glutathione S-transferase 12) (Glutathione S-transferase Yrs-Yrs) (P30713)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols. Highest activity towards ethacrynic acid and cumene hydroperoxide.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:8761485}. Nucleus {ECO:0000269|PubMed:8761485}.
Interaction partners:
- Glutathione S-transferase omega-1
- Glutathione S-transferase alpha-3
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S-transferase Mu 1
- Glutathione S-transferase Mu 7
- Hematopoietic prostaglandin D synthase
- Glutathione S-transferase kappa 1
- Glutathione S-transferase omega-2
- Glutathione S-transferase P
- Glutathione S-transferase
Sequence:
MGLELYLDLLSQPSRAVYIFAKKNGIPFQLRTVDLLKGQHLSEQFSQVNCLKKVPVLKDGSFVLTESTAILIYLSSKYQVADHWYPADLQARAQVHEYLGWHADNIRGTFGVLLWTKVLGPLIGVQVPEEKVERNRNSMVLALQRLEDKFLRDRAFIAGQQVTLADLMSLEELIQPVALGCNLFEGRPQLTAWRERVEAFLGAELCQEAHNPIMSVLGQAAKKTLPVPPPEAHASMMLRIARIP