wanglab/gogpt-training-data huggingface dataset:
Protein: Vitellogenin 1 (Vitellogenin 1 precursor) (Q1LWN2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Estrogen receptor
- Aromatase
- Esr2a protein
- Estrogen receptor 2b
- Follicle-stimulating hormone beta subunit
- 17-beta-hydroxysteroid dehydrogenase type 3
- Lhb protein
Sequence:
MRAVVLALTVALVACQQFNLVPEFAHDKTYVYKYEALLLGGLPQEGLARAGIKVSSKVLISATTENTYLMKLMDPLLYEYAGTWPKDPFVPATKLTSALAAQLQIPIKFEYANGVVGKVFAPAGVSPTVMNLHRGILNILQLNLKKTQNIYEMQEAGAQGVCRTHYVINEDPKANHIIVTKSKDLSHCQERIMKDVGLAYTERCAECTERVKSLIETATYNYIMKPADNGALIAEATVEEVYQFSPFNEIHGAAMMEAKQTLAFVEIEKTPVVPIKADYMPRGSLQYEFATEILQTPIQLMKISDAPAQIVEVLKHLVSNNKDMVHDDAPFKFVQLVQLLRVASLEKIEAIWSQFKDKPVYRRWLLDALPAVGTPVIIKFIKEKFLAGEFTTPEFIQTLVIALQMVTADPETIKMTASLATHEKFATIPALREVVMLGYGSLIAKYCVAVPTCPAELLRPIHEIATEAISKNDIPEITLALKVMGNAGHPSSLKPIMKLLPGLRTAANALPIRVQVDAILALRNIAKKEPKLVQPVALQLVLDRALHPEVRMVACIVLFEAEPSVALVSSLAGALRIEPNMHVASFAYSHIKSLTRITAPDMASVAGAANVAIKLMSRKLDRLNYRYSRAFQMDYYYTPLMIGAAGSAYMINDAATILPRAVVAKARAYLAGAAADVIEFGVRTGGIHEALLKSPAADESADRITKIKRTLRALTNWKALPTDKPLASAYLKVFGQEVAYVNFDKTIIEEAIPMATGPKPRALLKEALKALQEGVAFQYAKPLLAAEVRRILPTAVGVPMEFSWYTAAVAAASVNVQATITPALPEKLESMTYEQLKKTDVQFQAEARPSVALQTFAVMGVNTAFIQAAVMARGKIRTIAPGKVAARADILKGNYKVEALPVELPEHIASASFETYAVVRNIEDHSAERSVPLVPELSLQNSQASYAGDLSSEMSSVASVRAPAPFDRTLCYAVPYIEIKGCVEVHSHNAAFIRNSTLFYIIGHHSVRAAVARAEGPAVERLEFEVQVGPRAAERLVKQINIIDDDTPEGQAFLLKLREILDTEAKNAPVSSESSSSRNSRSSSSRSTSTSTSSSSSSSSSSSSSSSSSMSSSRMSKTATIIEPFRKFHKDRYLAHHSATKDTSSGSAAASFEQMQKQNRFLGNDIPPVFAIIARAVRADQKLLGYQLAAYFDKPTARVQLIVSSIAENDNMKICADGALLSKHKVTGKFSWGAECKQYAVFAKAEAGVLGEFPAARLEVEWERLPIIVTTYAKKLGKHILTAAYDTGFRFERATNSEKEIELTAALPSQRSLNIIARIPEITMSKRDIYLPVAVPINPDGTFSIETYEDFLAWIQKYIKEE
Protein: Ecto-NOX disulfide-thiol exchanger 1 isoform 1 (A0A024RDT8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
Protein: Probable DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) (AtMCM8) (Q9SF37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable DNA helicase that plays a role in meiotic double-strand break (DSB) repair, but seems not required for recombination with the homologous chromosome. May be involved with RAD51 in a backup pathway that repairs meiotic DSB without giving meiotic crossover, in parallel to the meiotic homologous recombination which relies on DMC1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM5
- Cell division cycle 45
- Minichromosome maintenance 10
- Cell division control protein 6 homolog
- Origin of replication complex subunit 5
- Origin of replication complex subunit 1B
- CDT1-like protein b
Sequence:
MGFYGGGSMASGRPESTGIDSLGIGKILAVYIKDNENLAIDEDKLQLTAELIRVFSASPGRDIVSQVNEDGGGSFSLSLDLQQFKKISDIENFFINLEDNPKGVIPCMNAAVHKVLFDQWETNEFENVMKINVRLHNYPESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAFDCGKCKTGITREFTDGKFSPPLKCDSHGCKSKTFTPIRSSAQTIDFQKIRVQELQKPEDHEEGRVPRTVECELMEDLVDICIPGDVVTVTGIIGVINNYMDIGGGKSKTKNQGFYYLFIEAVSVKNTKRQSAFENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDTFRRILHSVCPSIYGHEIVKAGITLSLFGGVRKHSMDRNKVPVRGDIHVIIVGDPGLGKSQLLQAAAAISPRGIYVCGNATTRAGLTVAVVKDSMTNDYAFEAGAMVLADGGLCCIDEFDKMTTEHQALLEAMEQQCVSVAKAGLVASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVSEHIMSLHSASGETSPALKKFKPVNAASQNAGYANMHAEGNSLLSRLRLDSEKDDDFSPVPGQLLRKYISYARNFVNPKMSKDAGEIIQKFYLKLRDHNTSADSTPITARQLESLVRLAQARARVDLREEITVQDAMDVVEIMKESLYDKLIDEHGVVDFGRSGGMSQQKEAKRFLSALDKQSELQQKDCFSVSEMYSLADRIGLRVPDIDTFLENLNIAGYLLKKGPKTYQVLSSSYSRSQSSRSR
Protein: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase (EC 3.6.1.62) (D4AE80)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Decapping mRNA 2
- 5'-3' exoribonuclease 1
- Enhancer of mRNA-decapping protein 3
- Enhancer of mRNA-decapping protein 4
- Probable ATP-dependent RNA helicase DDX6
- Protein PAT1 homolog 1
- Proline-rich nuclear receptor coactivator 2
- 5'-
- Regulator of nonsense transcripts 1
- Nonsense-mediated mRNA decay factor
Sequence:
MALSCSPVRPRPRGSAWRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEEARRAQQAARDKQSPSQANGCSDQRPIDILEMLSRAKDEYERNQMGGSNISSPGLQPSSQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAPMGLESEDTDKLLGDAPQKEPSSFLPFPFEQSGGAPQAENLGVHSVTHHTVQPEVSAPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTMMQAVRTTPRQKSPLLNQPVPELSHSSLIASQSPFRAPVSLANTAGTAIPSSDLLQKLRLTPQHDQIQAQPLGKGAMAPNFSSAAGQLATPESFIEPSSKTAAARAAVAASLSNMVLAPTLQSMQQNQDPEVFAQPKVLPSAIPIAGPPLVTATTTAVSSVLLSPSVFQQTVPRSADLERKASCPSPLTIGAENQRKPSIILSRSQLQDTLIHLIKNDSGFLSTLHEVYLQVLTKSKDNHSL
Protein: U17-myrmicitoxin-Tb1a (U17-MYRTX-Tb1a) (Secapin) (A0A6M6RE84)
Organism: Tetramorium bicarinatum (Tramp ant)
Function: Non-toxic peptide.
Subcellular location: Secreted {ECO:0000269|PubMed:30149710}.
Interaction partners:
Sequence:
MEKNRTNIFSVYLMITFLLISIFITMVMSDGEATIINAPNRCPPGHVVVKGRCRIAG
Protein: Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI) (Q92185)
Organism: Homo sapiens (Human)
Function: Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Beta-1,4 N-acetylgalactosaminyltransferase 1
- Lactosylceramide alpha-2,3-sialyltransferase
- Type 2 lactosamine alpha-2,3-sialyltransferase
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- Alpha-
- Beta-hexosaminidase subunit beta
- Beta-hexosaminidase subunit alpha
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
Sequence:
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDTSLQPTS
Protein: RH03791p (Q8SZM4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSSSRRSFSGGSENEGGRGSDYYRSRPGSRYSRSRSRSRERNRSHGGIRHRNSRSRSRDRDRSPVFRNDQHRGGRGGAGNGDPDFYHSLINDDYRDQDERNYNSRSNFENRQFRRHDSFDRRHRDRDGESDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDHRMYNGGGSNHNRDRDRDRDREQDRERDRDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDERVSMRYSHKRIQDWNCYKCGVCNFKFRFYCFVCKTSREDSETTFSSGSEGVDEVSTILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNISAVSPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYTEYYTADINKNNRDSHLTEANSGAAVALSAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKGNDGKIYPTPDVTQYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRGNQGGYADVGFSILEKKERGKLNDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEVLQKHLKMSTLHKENLAKLNQNTSSSIEEALAYRDRAKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKQSTSATPAMPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNKSGQMIPGNDYKSYIKKMMKQRYENA
Protein: Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) (P52299)
Organism: Xenopus laevis (African clawed frog)
Function: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P52298}. Cytoplasm {ECO:0000250|UniProtKB:P52298}.
Interaction partners:
Sequence:
MALSALRSDSYVDLSQYRDQHFRGNRSDQESLLKQSCTLYVGNLSFYTTEEQIHELFSKSGDVKRIVMGLDKVKKTACGFCFVEYYTRADAEQAMRFINGTRLDDRIVRTDWDAGFKEGRQYGRGKSGGQVRDEYRQDYDAGRGGYGKVVQSF
Protein: Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) (P52732)
Organism: Homo sapiens (Human)
Function: Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:37728657}.
Interaction partners:
- Disks large-associated protein 5
- Centrosomal protein of 55 kDa
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Kinesin-like protein KIF23
- Abnormal spindle-like microcephaly-associated protein
- Centromere-associated protein E
- Cell division cycle protein 20 homolog
- Cyclin-dependent kinase 1
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Dual specificity protein kinase TTK
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
Protein: Cytochrome c-type protein NrfH (Q9S1E6)
Organism: Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / CCUG 13145 / JCM 31913 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Function: Subunit of the nitrite reductase complex that mediates electron transfer from quinol to the catalytic subunit.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Periplasmic side {ECO:0000305}.
Interaction partners:
- Cytochrome c-552
- Periplasmic nitrate reductase, electron transfer subunit
- Periplasmic nitrate reductase
- Hydroxylamine reductase
- Glutamate dehydrogenase
- Nitrogenase iron protein
- Uncharacterized protein
- Nitrogenase molybdenum-iron protein alpha chain
- Nitrogenase molybdenum-iron protein beta chain
- Glutamine synthetase
Sequence:
MNKSKFLVYSSLVVFAIALGLFVYLVNASKALSYLSSDPKACINCHVMNPQYATWQHSSHAERASCVECHLPTGNMVQKYISKARDGWNHSVAFTLGTYDHSMKISEDGARRVQENCISCHASLSSTLLENADRNHQFNDPKGASERLCWECHKSVPHGKVRSLTATPDNLGVREVK
Protein: Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt) (P82916)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS25
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein bS1m
Sequence:
MSVVRSSVHAKWIVGKVIGTAMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLKALPVPRTKHVKHELAEIVFKVGQVVDPVTGKRCAGTTYLESPVDLETTPLAKNLEELSLSTTQ
Protein: TBC1 domain family member whacked (Q9VGL8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows. Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus.
Subcellular location: Apical cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:22407366}. Cytoplasmic vesicle {ECO:0000269|PubMed:22407366}. Cell projection, filopodium {ECO:0000269|PubMed:22407366}. Note=Restricted to the lumenal membrane of tracheal terminal cells with increased accumulation at the growing tips of seamless tubes. Colocalizes with Rab35 at the apical membrane, cytoplasmic puncta (likely to be vesicles) and filopodia. {ECO:0000269|PubMed:22407366}.
Interaction partners:
- LD21953p
- Bitesize, isoform I
- ADP-ribosylation factor 6
Sequence:
MATAPRSLDTISLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEAESSGSGNGHRRNMPTL
Protein: Choline/ethanolamine kinase (O17610)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFRLSSILVFHFLRRNLKTSSKFVRRMVSLEVPTESPCISRRAPSEECEIAFSHDDPTLMWKDRTTDCVDLKKVFSKFDSSAPISGEILFRARFLCAKYLGGAWRKVKIEEFRIRAITGGMSNLLFLVELPAHLTPIQMEPEKALLRVHCQSDIDQLLSESVVFTLLSERNLGPKMLGVFPGGRFEQFIPSRALQCLEISKPGLSKLIAPIVARVHTLDAPIPKEPQTLQTARQWLERFKKTPAGERPIEMYLTQAKVPKSDYPSTITVAQLERELNFVEFFLQHSHSPVVFSHNDLQEGNFLLIDGYKLADDGTVLTPDGKPTNDDPLSLIDFEYCSYNYRGFDLGNHFCEYGYDYNEAEAPYYKIHQHYFEVEKERKVFCEAYLDEVYKMRACGDNPHFPSDLVTGDREKDLNKIIEESILFMPVSNIFWVCWSLINAEESSIAFDYGAYGRDRLALYFHQKKNLEKYLSNL
Protein: Beta-amyrin 28-monooxygenase (EC 1.14.14.126) (Beta-amyrin 28-oxidase) (Cytochrome P450 716A44) (A0A3Q7HBJ5)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Catalyzes the carboxylation of beta-amyrin at the C-28 position to form oleanolate. Catalyzes the carboxylation of alpha-amyrin at the C-28 position to form ursolate.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MELLYVCLVCVFVFLVSLLLLYKKKSGEGLPPGKTGWPVFGESLEFLSSGWKGHPEKFIFDRVAKYSSSVFKTHLLGEEAAVFCGASANKFLFSNENKLVQAWWPNSVNKVFPSSTQTSSKEEAIKMRKMLPNFFKPEALQRYVGIMDHITQRHFATGWENKEQVVVFPLTKRYTFWLACRLFLSVEDPKHVAKFADPFDVLASGLISIPIDLPGTPFNRAIKASNFIRKELVRIIKQRKIDLGEGKVSSTQDILSHMLLTCDENGKFLGDLDIADKILGLLIGGHDTASSACSFIVKYLAELPHIYQRVYTEQMEIAKSKGPGELLRWEDIQKMKYSWNVACEVLRLAPPLQGAFREALSDFMFNGFYIPKGWKIYWSANSTHKREEFFPDPEKFDPSRFEGSGPAPYTFVPFGGGPRMCPGKEYARLEILVFMHHLVKRFKFEKIIPHEKIIVNPMPIPANGLPLRLYPHHHNP
Protein: Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) (P9WIU7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M.tuberculosis in the host.
Interaction partners:
- Diaminopimelate epimerase
- 4-hydroxy-tetrahydrodipicolinate reductase
- 4-hydroxy-tetrahydrodipicolinate synthase
- Homoserine dehydrogenase
- Homoserine kinase
- Aspartate-semialdehyde dehydrogenase
- Aspartokinase
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Threonine synthase
- Arginine--tRNA ligase
Sequence:
MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR
Protein: Peptidase M20/M25/M40 family protein (F4JPZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASSSKALIESIGSLDKDSYVSLLSKLIGESKFVQNNPPELIPQEDLIVKHVLDSLRPYSTETGGGPLVINHVAYHSGRGNLIVEYPGSVPGKILSFVGMHMDVVTANPDDWEFDPFSLSIDGDKLRGRGTTDCLGHVALVTELMKKLGQAKPALKSTVVAVFIASEENSSIPGVGVDMLVKDKLLDKLKSGPLLVSILYWIDTADKQPCVGTGGMIPWKLQFTGKLFHSGLAHKAINAMELAMEGLKEIQARFYRDFPPHPQEEVYGFATPSTMKPTQWCYPAGGINQIPGECTVSGDVRLTPFYDVKEVITKLQEYVDDINGNIERLETRGPVSKYVLPDENLRGRLTLSFDEASAGVACNLDSPGFHVLCKATEEVVGHVKPYSITGTLPLIRDLQDEGFDVQTSGYGLMATYHAKNEYCLLTDMCQGFDVFIRIISQLEQV
Protein: Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII) (Q9XSC9)
Organism: Bos taurus (Bovine)
Function: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular location: Secreted {ECO:0000269|PubMed:8547333}.
Interaction partners:
- CD320 antigen
- Cubilin
- E3 ubiquitin-protein ligase CBL
- Methionine synthase
Sequence:
MGHLGALLFLLGGLGALANICEITEVDSTLVERLGQRLLPWMDRLSQEQLNPSIYVGLRLSSLQAGAKEAHYLHSLKLSYQQSLLRPASNKDDNDSEAKPSMGQLALYLLALRANCEFIGGRKGDRLVSQLKRFLEDEKRAIGHNHQGHPRTSYYQYSLGILALCVHQKRVHDSVVGKLLYAVEHKPHLLQDHVSVDTMAMAGMAFSCLELSNLNPKQRNRINLALKRVQEKILKAQTPEGYFGNVYSTPLALQLLMGSLRPSVELGTACLKAKAALQASLQHKTFQNPLMISQLLPVLNQKSYVDLISPDCQAPRALLEPALETPPQAKVPKFIDVLLKVSGISPSYRHSVSVPAGSSLEDILKNAQEHGRFRFRTQASLSGPFLTSVLGRKAGEREFWQVLRDPDTPLQQGIADYRPKDGETIELRLVGW
Protein: Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) (O43462)
Organism: Homo sapiens (Human)
Function: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation.
Subcellular location: Membrane {ECO:0000305|PubMed:19361614}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:19361614}. Golgi apparatus membrane {ECO:0000305|PubMed:16417584}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Membrane-bound transcription factor site-1 protease
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Cyclic AMP-responsive element-binding protein 3-like protein 3
- Sterol regulatory element-binding protein 2
- Cyclic AMP-responsive element-binding protein 3-like protein 1
- Sterol regulatory element-binding protein 1
- Sterol regulatory element-binding protein cleavage-activating protein
- Sorting and assembly machinery component 50 homolog
- Cyclic AMP-responsive element-binding protein 3-like protein 2
- Cyclic AMP-responsive element-binding protein 3-like protein 4
Sequence:
MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR
Protein: Serine-peptidase (A1E5L3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLELIVIVSLIALAGAQLVPENSCPDYFRYVNDAFQGVQGEITLPSLMRGRNRIDIRFSQRGEQDASAVGSLIPYPDENAVRQLTGSAKFRIAVRPNSSNGLPKLTRLSYSEQILCSASEYRPPNSFFNRFYELDISGSLASFPSSVFNPFTRDGLDVNVQTVFYPTSSRGNDIWRGFTQPWTTVSNRSPAVVTPAPTPTEIFWNQPVPSVPITFAPPVPTITSSPAPPPPPPPPLPTPPAVVTVPPATPPPHRFDPRSQISSVVCGREGSTTPFIVRGNEFPRGQYPWLSAVYHKEVRALAFKCGGSLISSSIVISAAHCVHRMTEDRVVVGLGRYDLDDYGEDGAEMRNVMRLLWHPDYNTRSYSDADIALITIERPVTFNDIIAPICMWTVEASRTVSTTGFIAGWGRDEDSSRTQYPRVVEAEIASPTVCASTWRGTMVTERSLCAGNRDGSGPCVGDSGGGLMVKQGDRWLLRGIVSAGERGPAGTCQLNQYVLYCDLSKHINWISENIRLKHPDLLCGQSN