wanglab/gogpt-training-data huggingface dataset:
Protein: Patched-related, isoform A (Patched-related, isoform B) (Patched-related, isoform C) (RE45036p) (Q86P36)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Scavenger receptor class C, type II, isoform A
- LD15563p
- GEO04221p1
- GEO09613p1
- Serine/threonine-protein kinase par-1
- Uncharacterized protein, isoform A
- Uncharacterized protein
Sequence:
MTCGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKDNCARWENECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWLFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYYMQYPSIGINGPYGSKGFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESPTRRYDDGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRRSPFENYRQDVEIDMQKARRNSHGDVIDLHGTPNSSVEERFRRRGEPFSAESGDDSSYRHQQIMAMPAAGSAPSAKRYHRRRSSEDSTSRHQRWPANIEERRARRAYSPAHNRPETALTSYAYRSSSHHNLYQPNGKSSKYPPTYQYGDYYH
Protein: Salicylate biosynthesis isochorismate synthase (EC 5.4.4.2) (Isochorismate mutase) (Q51508)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in the conversion of chorismate to salicylate.
Interaction partners:
- Pyochelin synthase PchD
- Pyochelin synthetase PchE
- Pyochelin synthetase PchF
- Isochorismate pyruvate lyase
- Pyochelin biosynthetic protein PchC
- Pyochelin biosynthetic protein PchG
- Fe
- Probable ATP-binding component of ABC transporter
- Anthranilate synthase component 2, pyocyanine specific
- Anthranilate synthase component 2
Sequence:
MSRLAPLSQCLHALRGTFERAIGQAQALDRPVLVAASFEIDPLDPLQVFGAWDDRQTPCLYWEQPELAFFAWGCALELQGHGEQRFARIEENWQLLCADAVVEGPLAPRLCGGFRFDPRGPREEHWQAFADASLMLAGITVLREGERYRVLCQHLAKPGEDALALAAYHCSALLRLRQPARRRPSGPTAGAQGDASAQERRQWEAKVSDAVSSVRQGRFGKVVLARTQARPLGDIEPWQVIEHLRLQHADAQLFACRRGNACFLGASPERLVRIRAGEALTHALAGTIARGGDAQEDARLGQALLDSAKDRHEHQLVVEAIRTALEPFSEVLEIPDAPGLKRLARVQHLNTPIRARLADAGGILRLLQALHPTPAVGGYPRSAALDYIRQHEGMDRGWYAAPLGWLDGEGNGDFLVALRSALLTPGRGYLFAGCGLVGDSEPAHEYRETCLKLSAMREALSAIGGLDEVPLQRGVA
Protein: Casein kinase I isoform beta (CKI-beta) (EC 2.7.11.1) (P35507)
Organism: Bos taurus (Bovine)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Catenin beta-1
- Axin 2
- Glycogen synthase kinase-3 beta
- Adenomatous polyposis coli protein
- APC regulator of WNT signaling pathway 2.
- Protein smoothened
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- G protein-coupled receptor kinase 3
- Beta-adrenergic receptor kinase 1
Sequence:
MASSSRPKTDVLVGGRYKLVREIGFGSFGHVYLAIDLTNHEQVAVKLESENTRQPRLLHEKELYNFLQGGVGIPQIRWYGQETDYNVLVMDLLGPSLEDLFNFCSRRFSMKTVLMLADQMISRIEYVHSRNLIHRDIKPDNFLMGTGPQWKKLFLVDFGLAKKYRDNRTGQHIPHRSGKSFIGTPFCASISAHLGIEQSRRDDMESIGYVLMYFNRGSLPWQGLKAATLKQKCEKISEMKMTTPVDVLCKGFPIEFAMYLKYCLRLSFEEAPDYRYLRQLFRLLFRKLSYQHDYAFDWIVLKQKAEQQASSSSGEGQQAQTPTGKSDNTKSEMKHS
Protein: Uncharacterized carboxypeptidase C24C9.08 (EC 3.4.17.-) (O13968)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Carboxypeptidase Y
- Protein arg11
- Argininosuccinate synthase
- Vacuolar protein sorting/targeting protein 10
- Vacuolar protein sorting-associated protein 9b
- ESCRT-I complex subunit vps23
- Vacuolar protein sorting-associated protein vps901
- Vacuolar protein sorting-associated protein 27
Sequence:
MSTSNDPVVSSHDPIKQEKEQETDLEAQVEHKKRNERGNAFVGFLILIFVYYLLRGGSNDNDKQEMSHSPGSCMDSESAAVSTSAKCYIPPVLTPAKEPKLGDDVSGIDYIRSPEFFNDSLVRFQELLRIPTVCYDDMGDVGDDDRFDIFAVFQDKVRELYPNIFKKLKVEYVNTYGLLITLEGSNKDLKPLVLMGHQDVVPVNQASLDRWYFPPFSATYHNGHVYSRGAADDKNSVVAILEALEILAISDYKPEQTVIASFGFDEEVSGYRGALPLAHKLYERYGKDGVALILDEGGFTINLFGTLFATVCVAEKGYMDVHLKLKTPGGHASIPPPHTNIGLMSKLVTQIEEPFGGELTFENPFYTTLQCFAENSADMDDNLRQLIKSGDTEKMTDLFSKSRLYRYFFETSIAVDVINGGVKVNALPEETTLAVNHRVDASKGLKQVYDRYGGLLEEFGHEYHVNVTLFNGETVVEYEDAIGHIFASTAKTLEPSPVSPYDESSDAYKKLAGAIRYTFGDGTSVTPALMPANTDTRHYWNLTSNIYRWTPVSTNSTSKNSFNGHTINENMRYDAHMDSIEFFYNFILVSDSGEEA
Protein: Probable ATP-dependent transporter SufC (P77499)
Organism: Escherichia coli (strain K12)
Function: Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12554644}.
Interaction partners:
- Iron-sulfur cluster assembly protein SufD
- Cysteine desulfurase
- Iron-sulfur cluster assembly protein SufB
- Iron-sulfur cluster assembly protein SufA
- Cysteine desulfuration protein SufE
- Iron-sulfur cluster assembly scaffold protein IscU
- Cysteine desulfurase CsdA
- 2Fe-2S ferredoxin
- Sulfur acceptor protein CsdE
- HTH-type transcriptional regulator IscR
Sequence:
MLSIKDLHVSVEDKAILRGLSLDVHPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTVEFKGKDLLALSPEDRAGEGIFMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDFQDLMEEKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMAVLEPELCILDESDSGLDIDALKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQGYGWLTEQQ
Protein: Vacuolar protein sorting-associated protein 28 homolog (ESCRT-I complex subunit VPS28) (Q9NA26)
Organism: Caenorhabditis elegans
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
Subcellular location: Endosome {ECO:0000250}.
Interaction partners:
- Tumor susceptibility gene 101 protein
- Multivesicular body subunit 12A
- VPS37 C-terminal domain-containing protein
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein-sorting-associated protein 25
- Charged multivesicular body protein 6
- Charged multivesicular body protein 3
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Charged multivesicular body protein 2a
- Charged multivesicular body protein 5
Sequence:
MSSQNANLMREVRLFENHSEREQMENLSELFAVLNALEHLEKMFSRDHVSADEYKSECFKLIDQYKVTMRLVHGATSIEDFAKKYRLHCPAAIERIREGRPITVKDDQGNVLKHIASIVEQFITFLDALRLNTRAVDDLYPGLDDLYNAINTTSRVPIDAIVTTKVKKWHDRLSSMAASDEISDEDARQMIFDVESAYQAFNKALNELKH
Protein: Bromodomain containing 8 (Q9VAM5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- YEATS domain-containing protein 4
- Inhibitor of growth protein
- Chromatin modification-related protein MEAF6
- MRG/MORF4L binding protein
- Transcription-associated protein 1
- RuvB-like helicase 1
- RuvB-like helicase 2
- NuA4 complex subunit EAF3 homolog
- Brahma associated protein 55kD
Sequence:
MSAGVQERLQLSRMPLDTWSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLAVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQDCQAIKEFSQLPDVQAGITATPVSNTGSLRADKSSGSKARSGSRKSQRHH
Protein: Carboxypeptidase Q (E5RH35)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAIINLAVYGKAQNRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGEESAVMLEPRIHKI
Protein: Inhibitor of vertebrate lysozyme (P0AD59)
Organism: Escherichia coli (strain K12)
Function: Strong inhibitor of lysozyme C.
Subcellular location: Periplasm.
Interaction partners:
- Membrane-bound lysozyme inhibitor of C-type lysozyme
Sequence:
MGRISSGGMMFKAITTVAALVIATSAMAQDDLTISSLAKGETTKAAFNQMVQGHKLPAWVMKGGTYTPAQTVTLGDETYQVMSACKPHDCGSQRIAVMWSEKSNQMTGLFSTIDEKTSQEKLTWLNVNDALSIDGKTVLFAALTGSLENHPDGFNFK
Protein: WAG22 antigen (P9WIG5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv3785
Sequence:
MSFVIAVPETIAAAATDLADLGSTIAGANAAAAANTTSLLAAGADEISAAIAALFGAHGRAYQAASAEAAAFHGRFVQALTTGGGAYAAAEAAAVTPLLNSINAPVLAATGRPLIGNGANGAPGTGANGGDAGWLIGNGGAGGSGAKGANGGAGGPGGAAGLFGNGGAGGAGGTATANNGIGGAGGAGGSAMLFGAGGAGGAGGAATSLVGGIGGTGGTGGNAGMLAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFTTGGVGGAGGQGHTGGAGGAGGAGGLFGAGGMGGAGGFGDHGTLGTGGAGGDGGGGGLFGAGGDGGAGGSGLTTGGAAGNGGNAGTLSLGAAGGAGGTGGAGGTVFGGGKGGAGGAGGNAGMLFGSGGGGGTGGFGFAAGGQGGVGGSAGMLSGSGGSGGAGGSGGPAGTAAGGAGGAGGAPGLIGNGGNGGNGGESGGTGGVGGAGGNAVLIGNGGEGGIGALAGKSGFGGFGGLLLGADGYNAPESTSPWHNLQQDILSFINEPTEALTGRPLIGNGDSGTPGTGDDGGAGGWLFGNGGNGGAGAAGTNGSAGGAGGAGGILFGTGGAGGAGGVGTAGAGGAGGAGGSAFLIGSGGTGGVGGAATTTGGVGGAGGNAGLLIGAAGLGGCGGGAFTAGVTTGGAGGTGGAAGLFANGGAGGAGGTGSTAGGAGGAGGAGGLYAHGGTGGPGGNGGSTGAGGTGGAGGPGGLYGAGGSGGAGGHGGMAGGGGGVGGNAGSLTLNASGGAGGSGGSSLSGKAGAGGAGGSAGLFYGSGGAGGNGGYSLNGTGGDGGTGGAGQITGLRSGFGGAGGAGGASDTGAGGNGGAGGKAGLYGNGGDGGAGGDGATSGKGGAGGNAVVIGNGGNGGNAGKAGGTAGAGGAGGLVLGRDGQHGLT
Protein: Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) (Q6XHB2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Latrophilin receptor-like protein A
Sequence:
MDSSQQLQESQQLQQQYTRVGIDVIGPMKDLIISVMNSLDTTFKIINETYRIVYFDTDETKLTSSNLDSDDEEFESDDDADEEADLQIQASCNLYTFDGKNRQSVDEIKRIVQHLNETQSQQNDNQAVPVIPTFFVVVNIGVGPSFVSEIKSAAGTTQFIEWIVNDQASKEVFKVSTNLLSHHKKQIELTHACTVGDVNYLDQIILSGVSTDQLKEAHKAGHAIVFDSLLTHNSNSLVVTGTMALLGAIVENGDRKGKRLSLSRSNLSRFPMSITQMCTHLVELDLSDNKITELPKDIQLLKSLRILILRGNLLEDIPLEICYLGDLKILELQENPLNNFPLSVVQSGTKNLLLFCKNILERKKSETWNKVKLMFVGQEGVGKTSLCQALKGSKKKKAELQVTGDTVSTEGVKIQNIKNKKVEFHAWDFGGQQVFYPTHQFFLTTHALYLVVFKLTDPNFAERVNYWVRQVKSNSSGAVPAIFLVGTHSDVCTPEQLQEAESILKANFVKYSRVKENTINFVCCATGKGIKELKKRLIHEAEKSHLIKKDIPGNYMVLEARLTNRGANPGRMAVSGSPIGGGSSAQLSSNAINSQKERYIDYDDYMNECKLSHLQPEEIKGATDFLHNLGIILHFDTPTLKNLVVLDPQWLADVMSSLITFSHNWIKRGILNHSELVAVWGGKYDQSLWPLLLKLLEKFEVSYELPNIAKSLIPSLLPEDAEGEISTIKDREWVTLPQAIESGRCQVFGCDYNFDFMPLGFFARLLLRILLISGVEVRTYWRNGVLLDILTPEQVKLQQSKQQQLQQQQQQQNNNESNDSSVNNNNNNNNNNNNNNIINSSSSSSLNLTQTSTSTSPSKLSLNNSQINNSNSTLNSQQLINPSVSPLSSTTPRHQALITFIKKKSFESKDKDSYKLNIEVRSFNTTIEKDHSASLFFQQILFTIDTLLASSYVGLEITRMIPCIHCVQKNPRADPYYFDFSSCISALQDGKPHLFCRNDPSIPVRIDYIAPDLCLKKVPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSELRNGNTTSTTTNTSSTTNNLNSANVSIASTSSNADDGSQTNNNNNNNNNNNNNNNNNSGSSIALSPSRSFEQQTTTTTTTTTSPSSPSTSFINSSGSYNTESYSVASSSTTNLLNTLNNANQPVNFIGTASVHKKMEVLAGVEAGETVWTKSADSSLCFWSTKKGHLINELKCPHTVATTMMIKVGKYIWEATNSNGIYIWDMGTMTIVQQLTTPHKGDVCLHFVEYGDNNGVWSGGSEGTVCLWDMQTFEKKHSFSLESAITAMSYFGNNTLYIASGSHIVVFKTKTLLMNVNQNWKHSTGSITSILAMKDEVWSGGSDGRIYIWKVKNEFELQKVQSLEAHHEKITSLIHLEDNVLSGSTDKCISLFKISDPKKPFTTQEHHKQGVTSIVKVQSHIVWAITSDTTTPLVLWNIPQKWEKKTANGILPRLKFFR
Protein: Wtf element wtf15 (G2TRU7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May act in meiotic drive.
Subcellular location: Spore membrane {ECO:0000250|UniProtKB:A0A482AT42, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSNNYTSLSSSLDEEMGLKAGHEIDLEGSPPSEHNSEEKSTLPSNSDILTSANPVSQASETPDHSIESNTGSTQSPTSHSLLLKFSFCIVYYSYFAIVVLGCVLPFEHTHTFLIAFLVIFGIISVILFSGSIYYYETWTKTVKHFLKKVISPFKKEYIVCAFLKTFVFYGLLKTIEHFLVLLSGDKWGWKCSTLSSILTPVSCISFCLNESVQLRSCSTHLFINTVAWIKSLGGGKNAFENNYNQLNETSPEDLV
Protein: ELMO domain-containing protein (Q38FQ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGSSMSCLEVGSDSRCFGLPTPVMAALVAGAGGLLFLLYKVYRCQTRKVCRRTPVLQSVNIAVNQPELAVKKAAEHIMKGEITTVGQLVFFFRGGEEKAIRINRKLFECLQEAFPVGTADQPPADGANGAEEHVCHMMQQLCRCEEQAARLEAERATAFDDGNPQHIALLERLWVAAGKPKSAFARRSSEWNDLGFQGMDPVTDLRGGGVLALRQFLHFAEAYNDHLKGMMEFNKRALADKKNHWYLLAVVSIQFTAQLLLQRDYKVFLPQLEVLYDTISRGHKPGILTGSLRSAAAMSEVGTQSIGALSQNSVDCSEGEETSDFEVGYFALHHQLLLSFKECWHRDLPHVMEYNKYLSKFLESFFSPE
Protein: Histidine decarboxylase (HDC) (EC 4.1.1.22) (P16453)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the biosynthesis of histamine from histidine.
Interaction partners:
- Histamine N-methyltransferase
- Diamine oxidase [copper-containing]
- Amine oxidase
- Amine oxidase
- Cytosolic non-specific dipeptidase
- Histidine ammonia-lyase
- Beta-Ala-His dipeptidase
- Carnosine synthase 1
- Histamine H3 receptor
- Histamine H2 receptor
Sequence:
MMEPSEYHEYQARGKEMVDYICQYLSTVRERQVTPNVKPGYLRAQIPSSAPEEPDSWDSIFGDIEQIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPDFFLHHHPSSQGGGVLQRTVSESTLIALLAARKNKILEMKAHEPNADESSLNARLVAYASDQAHSSVEKAGLISLVKIKFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDKLSELGPICAREGLWLHVDAAYAGTAFLRPELRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTDMAKYFESLVRSDPVFEIPAERHLGLVVFRLKGPNCLTESVLKEIAKTGQVFLIPATIQDKLIIRFTVTSQFTTKDDILRDWNLIREAANLVLSQHCTSQPSPRAKNLIPPPVTRDSKDLTNGLSLESVNEGGDDPVQVRKIFRLPGDSLETTMDPFDDCFSEEASDTTKHKLSSFLFSYLSVQNKKKTMRSLSCNSMPMSAQKSPPPDASVKHGGFFRARIFSGFPEEMMMMKKGGFKKLIKFYSVPSFPECSSQCGTLQLPCCPLQAMV
Protein: Uncharacterized protein C14orf93 homolog (Q8K2W9)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MSFSATILFSPPSGSEARCCCCACKSETSQGSTGSQGGNPPASTPITVTGHGLAVQSSEQLLHIIYQRVDKAVGLAEAALGLARANNELLKQLQEEVGELRQGKVCTADEDRESRARTPPPEEPGVLKGSPGEASNSLPAMEEECDSVGSGVQVVIEELRQLGAASTVGQGPLGFFAAPQRDARLPGCTLAAVEGAPLLNPMADDYVASEGSIQRVLVPAYAKQLSPATQLAIQRASSETGPESGTKLPATRPEGVLGSAALDSALDESGAGGAGELSRSLGFVGSPCRIRGTGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSESIKSSWNISVVKFLLEKLKQELMVSPHNYTDKELKGACVAYFLTKRREYRNSLNPFKGLKEKEEKKLRSRRYRLFANRSSIMRHFGPEDQHLWKDVTEELMSDEEDSLNEPGVWVARSPRFRAQRLTELCYHLDANSKHGTKANRVYGPPSDRLPSVEAQLLPPELYNPNFQEDEGGGNEKGPVSPSYDQPHKTSCPDLNSFIEIKVEKDEYTL
Protein: Glutathione-S-transferase/glutaredoxin, putative (Q57WG5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 9,11-endoperoxide prostaglandin H2 reductase
Sequence:
MFTKGSMSRKLLCATGALAGLGFAGGYVTYQRRLEENRSCTAEDFNAAQDQTELQFALSHITDPKKCPPILLYRYSTCPFCATTKSFLDYNKIRYECVEVEPMFKKEISMSAYKKVPQLKFCVRGDDGPFLVDSEVIVSTVAKHVGMGKQLEDPEVKKWREWARGPMVRLLTLEFNSSLLNSWGSYSYIDNIETIPYKNKIFLKLVGAPVMYLVAQYVTKPRLLKSGDLLPTDDPKVKLHNEIDRFVKEGLLDGKKKFHGGSKPDLADLDTHGVLQSVRGHRLYNEIIEATTIKPWLERMDEAVGNEKYIPK
Protein: Zinc finger CCHC domain-containing protein 3 (Q9NUD5)
Organism: Homo sapiens (Human)
Function: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus. Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation. Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30135424}.
Interaction partners:
- Interferon-induced helicase C domain-containing protein 1
- Antiviral innate immune response receptor RIG-I
- Polyadenylate-binding protein-interacting protein 1
Sequence:
MATGGGAEEERKRGRPQLLPPARPAARGEEADGGREKMGWAQVVKNLAEKKGEFREPRPPRREEESGGGGGSAGLGGPAGLAAPDLGDFPPAGRGDPKGRRRDPAGEAVDPRKKKGAAEAGRRKKAEAAAAAMATPARPGEAEDAAERPLQDEPAAAAGPGKGRFLVRICFQGDEGACPTRDFVVGALILRSIGMDPSDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKREQEDCWENFVVLGRSKSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGSCTQDRCFRCGEEGHLSPYCRKGIVCNLCGKRGHAFAQCPKAVHNSVAAQLTGVAGH
Protein: bZIP transcription factor 29 (AtbZIP29) (Protein DRINK ME-LIKE) (Q8H1F0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that acts as a repressor of reproductive development, meristem size and plant growth. Regulates meristem size, cell size and cell number during plant development. Binds to the promoters of the cell cycle regulators CYCB1-2 and SMR4, and genes involved in cell wall organization, such as XTH9, EXPA1 and EXPA3. Possesses transactivation activity in yeast. Possesses transactivation activity in plant protoplasts. Plays a role in abiotic stress response by binding to the 5'-CAGCTG-3' DNA sequence found in the promoters of MYB44 and TRX8. Plays a role in osmosensory response by binding to the 5'-AGCTGT/G-3' DNA sequence found in the promoters of the hypoosmolarity-responsive genes CYP707A1 and CYP707A3. Binds to the 5'-AGCTGT-3' DNA sequence found in the promoter of the ZAT1 gene in response to abiotic stresses, such as oxidative stress, high-light, osmotic shock, salt and heat stresses.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25093810}. Nucleus {ECO:0000269|PubMed:25093810}. Note=Transiently accumulates in the nucleus when cells are exposed to hypoosmotic conditions. {ECO:0000269|PubMed:25093810}.
Interaction partners:
Sequence:
MGDTEKCNSDMIQRLHSSFGTTSSSIPKNPISQLDLNPNFIRSSAPQFSKPFSDSGKRIGVPPSHPNLIPPTSPFSQIPTTRQPGSHNFNPGGANHSRSMSQPNSFFSFDSLPPLSPSPFRDHDVSMEDRDSGVFNSNHSLPPSPFTRCNSTSSSSLRVGESLPPRKSHRRSNSDIPSGFNSMPLIPPRPLERSFSGGECADWSKSNPFVKKESSCEREGVGEREAMDDLFSAYMNLENIDVLNSSEADDSKNGNENRDDMESSRASGTKTNGSDTEGESSSVNESANNNMNSSGEKRESVKRRAAGGDIAPTTRHYRSVSVDSCFMEKLSFGDESLKPPPSPGSMSRKVSPTNSVDGNSGAAFSIEFNNGEFTAAEMKKIMANDKLAEMAMSDPKRVKRILANRQSAARSKERKMRYIVELEHKVQTLQTEATTLSAQLTLLQRDMMGLTNQNNELKFRLQAMEQQARLRDALNEALNGEVQRLKLAIGESSQNESERSKMQSLNAEMFQQLNISQLRQQPQQMQQQSHQQNHQNGTMATKSESNE
Protein: Periostin (Q6DMS3)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MKIFLLFTFSTFFLSAFEQAAASAHYDKILTHSRIRARDQGPNVCALQQVMGTKKKYFSTCRNWYQGSICGKKATVLYECCPGYMKMDGMRGCPAVVPIDHVYGTLGIVGATSTQQYSDVSKLREEIEGRGSFTFFAPSNEAWEQLSSEIHRNLIDNVNIELYNALHHHMVNKRMLTKDLKNGMTLVSMYNGQKLLINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTAVGNTIQDFIEVEDDLSSLRAAAITSDVLDTLGRPGYYTLFAPTNEAFERLPRGILERIMGDKVASEALVKFHILNTLQCSEAIMGGAVYETLEGNTLEVGCDGETLTVNGVKMVKRKDIVTSNGVIHLIDRVLIPDSAKQVIELGGAQQTTFTDLVTQLGLASSLRPEGQYTLLVPQNRAFSDDTLQMDQRLLKTILQNHIIKVKIGLNELYNGQELETIGGKLLRVFVYRTAVCVENSCMVRGSKEGRNGFIHVFRQIIKPAEKSLHEMLRNDKRFSVFLSLVKAADLDDVLSRPGAWTLFVPTNDAFKGLTDDDKAVLIRDKNALRNILLYHLTQGVFIGSGFEPGVTNILKTIQGGKLYLKTVNDTLLVNDLKSREPDLMATNGVIHVIDKLLYPADLPVGNDQLLTILKKLIKYIQIKFVRDSTFKEIPLTFYNPSITQLTKIIEGEPEFKIVREGETITKVIHGEPIIKTYTKIIDGRPVEVTEKKVTEERIIQGPEIKYTRITAGGTDNEENLKRLLEEEVTKVTKFIEGDAHLLEDEEIKRLLQGAGTEYTKVTKVIEGEPQIIEREIKKVRLEEAPVRKVQANKRTQGGSARRRTRLAYS
Protein: Prefoldin 5 (Predicted), isoform CRA_a (Prefoldin subunit 5) (B5DFN4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Prefoldin subunit 6
- Prefoldin subunit 2
- Prefoldin subunit 1
- Prefoldin subunit 4
- Prefoldin subunit 3
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit eta
Sequence:
MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLNKSNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVVEMMSQKIQQLTALGATQATAKA
Protein: S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) (Multicopy enhancer of UAS2) (Q07938)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Seems to be implicated in the regulation of the expression of the ADH2 gene.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Spermidine synthase SPE3
- Methylthioribose-1-phosphate isomerase
- Spermine synthase SPE4
- Adenine phosphoribosyltransferase 1
- Methylthioribulose-1-phosphate dehydratase
- Uridine nucleosidase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Ornithine decarboxylase
- Suppressor of disruption of TFIIS
Sequence:
MNRIKNTFSVAKRLKLSKVMTNSELPSIFEGTVDLGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYFNDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNLTNNGRNANILASKIIVSMAKEIPEFMHTGDGLRGSIKKSISTKPEAMSKETLERLRYLFPNYW
Protein: Guanine nucleotide-binding protein subunit gamma (P18852)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Implicated in the pheromone A- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response.
Subcellular location: Membrane; Lipid-anchor.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- Guanine nucleotide-binding protein alpha-1 subunit
- Protein STE5
- Pheromone alpha factor receptor
- Serine/threonine-protein kinase STE20
- Cyclin-dependent kinase inhibitor FAR1
- Cell division control protein 24
- Mitogen-activated protein kinase FUS3
- Serine/threonine-protein kinase STE7
- Pheromone a factor receptor
Sequence:
MTSVQNSPRLQQPQEQQQQQQQLSLKIKQLKLKRINELNNKLRKELSRERITASNACLTIINYTSNTKDYTLPELWGYPVAGSNHFIEGLKNAQKNSQMSNSNSVCCTLM