wanglab/gogpt-training-data huggingface dataset:
Protein: Tetraspanin (Q6P2T9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell surface {ECO:0000256|ARBA:ARBA00004241}. Endosome, multivesicular body {ECO:0000256|ARBA:ARBA00004559}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004155}. Melanosome {ECO:0000256|ARBA:ARBA00004223}. Membrane {ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
Interaction partners:
- Tumor susceptibility 101a.
- Sdcbp protein
- Scavenger receptor class B, member 2c
- Lysosome membrane protein 2a
- Lysosome membrane protein 2 isoform X1
- Lysosomal-associated membrane protein 2.
- Syndecan-binding protein
- Lysosomal-associated membrane protein 1b
- RAB27B, member RAS oncogene family.
- small monomeric GTPase
Sequence:
MAVEGGAKCVKYLLFFFNFIFWLCGLALIVLGILVHVSLHNTAILQGASGSPMVLIVVGVIIFFISFFGCCGAWKENQCMVVTFAIILSLIVITEIGAGIAGYIFRGKVNELLDQSFNTMIAGYNKTEEYRTTLDSIQKQLKCCGGNSSSDWVNFSADHISVPDSCCKNVTKNCGIGAMTKPTVIYLEGCQPILETRIKENILWIAVGALVIGFVQITGIVLACILSRAIRSGYEVM
Protein: Treble clef zinc finger domain-containing protein (Q388L7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 30S ribosomal protein S8, putative
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MFNRNFILRAAEFKQKSRWSSVWPNMRYGSMFLSYSVGRKLPMKGVNWVTRDSNRLLNFSNRYSAVISDIDVKRTEEELNVALSDIRWNDHRRIYWKCSFCGSSYRKNVSVRTKYHAGCNFCKKKYPSEVRGEQHGSPPVSQAAPELTEQLVDNGKRDNLATLAVTSKFYAEWTCRGCGGSYRSTIRSRTGQVEAGQCTLHPDIVAWSAYCPSCSWRPNMVPIAEEVSRSGQFLGLERSMEELGGQRGKQLPIPRRKRLAC
Protein: Protein disulfide-isomerase A2 (EC 5.3.4.1) (PDIp) (D3Z6P0)
Organism: Mus musculus (Mouse)
Function: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity).
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q13087, ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Endoplasmin
- ERO1-like protein beta
- DnaJ homolog subfamily B member 11
Sequence:
MDKQLLPVLLLLLGVSGSWGQGEEPGGPSEVLPEEPTGEEVPKEDGILVLNHRTLSLALQEHSALMVEFYAPWCGHCKELAPEYSKAAALLAAESAVVTLAKVDGPAEPELTKEFEVVGYPTLKFFQNGNRTNPEEYAGPKTAEGIAEWLRRRVGPSATHLEDEEGVQALMAKWDMVVIGFFQDLQGKDMATFLALAKDALDMTFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKETGLDLGDLSRFLVIHSMHLVTEFNSQTSPKIFAAKILNHLLLFVNQTLAQHRELLTDFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAEEAPTLRLINVETTKKYAPTGVIAITAASVAAFCQAVLHGEIKHYLLSQEIPPDWDQGPVKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYKDREDIVIAELDATANELEAFSVLGYPTLKFFPAGPDRKVIDYKSTRDLETFSKFLDSGGHLPKEEPKEPAASAPEAQANSTLGPKEEL
Protein: 13-hydroxylupanine O-tigloyltransferase (EC 2.3.1.93) ((-)-13alpha-hydroxymultiflorine/(+)-13alpha-hydroxylupanine O-tigloyltransferase) (HMT/HLTase) (Quinolizidine alkaloid O-tigloyltransferase) (Q5H873)
Organism: Lupinus albus (White lupine) (Lupinus termis)
Function: Acyl-CoA-dependent acyltransferase involved in the synthesis of lupanine alkaloids. Can use both (-)-13alpha-hydroxymultiflorine and (+)-13alpha-hydroxylupanine as substrates. Lower activity with (-)-3beta, 13alpha-dihydroxylupanine, but no activity with (+)-epilupinine and (-)-lupinine as substrates. Tigloyl-CoA, benzoyl-CoA and, more slowly, acetyl-CoA, propionyl-CoA and 2-butenoyl-CoA can act as acyl donors.
Interaction partners:
Sequence:
MAPQTQSLVFKVRRNPQELVTPAKPTPKEFKLLSDIDDQTSLRSLTPLVTIYRNNPSMEGKDPVEIIREALSKTLVFYYPFAGRLRNGPNGKLMVDCTGEGVIFIEADADVTLDQFGIDLHPPFPCFDQLLYDVPGSDGILDSPLLLIQVTRLKCGGFIFAVRLNHAMCDAIGMSQFMKGLAEIARGEPKPFILPVWHRELLCARNPPKVTFIHNEYQKPPHDNNNNNFILQHSSFFFGPNELDAIRRLLPYHHSKSTTSDILTAFLWRCRTLALQPENPNHEFRLLYILNARYGRCSFNPPLPEGFYGNAFVSPAAISTGEKLCNNPLEYALELMKEAKSKGTEEYVHSVADLMVIKGRPSYFYNDVGYLEVSDLTKARFRDVDFGWGKAVYGGATQGYFSSILYVSYTNSKGVEGIMALTSLPTKAMERFEKELDDLFKTKDKSQILRSHI
Protein: tRNA hydroxylation protein P2 (EC 3.4.-.-) (O32035)
Organism: Bacillus subtilis (strain 168)
Function: Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-methoxyuridine (mo5U) biosynthesis.
Interaction partners:
- tRNA 5-hydroxyuridine methyltransferase
- tRNA hydroxylation protein P1
- Uridine kinase
- Uncharacterized zinc protease YmfH
- tRNA uridine
- UPF0741 protein YwzC
- Putative tRNA
Sequence:
MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSREDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMAARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIEIQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENGTHIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDEYEAKKEDWIERIESIQPVNRKIDTGFFFKETVY
Protein: Protein FEZ (NAC domain-containing protein 9) (ANAC009) (Q9ZVH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes periclinal root capforming cell divisions. Activates expression of its negative regulator SMB in a feedback loop for controlled switches in cell division plane.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:19081078}.
Interaction partners:
- WUSCHEL-related homeobox 5
- CLAVATA3/ESR
- Putative cyclin-D6-1
- Serine/threonine-protein kinase-like protein ACR4
- Ethylene-responsive transcription factor ERF115
Sequence:
MGDRNNDGDQKMEDVLLPGFRFHPTDEELVSFYLKRKVQHNPLSIELIRQLDIYKYDPWDLPKFAMTGEKEWYFYCPRDRKYRNSSRPNRVTGAGFWKATGTDRPIYSSEGNKCIGLKKSLVFYKGRAAKGVKTDWMMHEFRLPSLSEPSPPSKRFFDSPVSPNDSWAICRIFKKTNTTTLRALSHSFVSSLPPETSTDTMSNQKQSNTYHFSSDKILKPSSHFQFHHENMNTPKTSNSTTPSVPTISPFSYLDFTSYDKPTNVFNPVSCLDQQYLTNLFLATQETQPQFPRLPSSNEIPSFLLNTSSDSTFLGEFTSHIDLSAVLAQEQCPPLVSLPQEYQETGFEGNGIMKNMRGSNEDHLGDHCDTLRFDDFTSTINENHRHHQDLKQNMTLLESYYSSLSSINSDLPACFSSTT
Protein: Zinc finger protein 613 (Q6PF04)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 799
Sequence:
MIKSQESLTLEDVAVEFTWEEWQLLGPAQKDLYRDVMLENYSNLVSVGYQASKPDALFKLEQGEPWTVENEIHSQICPEIKKVDNHLQMHSQKQRCLKRVEQCHKHNAFGNIIHQRKSDFPLRQNHDTFDLHGKILKSNLSLVNQNKRYEIKNSVGVNGDGKSFLHAKHEQFHNEMNFPEGGNSVNTNSQFIKHQRTQNIDKPHVCTECGKAFLKKSRLIYHQRVHTGEKPHGCSICGKAFSRKSGLTEHQRNHTGEKPYECTECDKAFRWKSQLNAHQKIHTGEKSYICSDCGKGFIKKSRLINHQRVHTGEKPHGCSLCGKAFSKRSRLTEHQRTHTGEKPYECTECDKAFRWKSQLNAHQKAHTGEKSYICRDCGKGFIQKGNLIVHQRIHTGEKPYICNECGKGFIQKGNLLIHRRTHTGEKPYVCNECGKGFSQKTCLISHQRFHTGKTPFVCTECGKSCSHKSGLINHQRIHTGEKPYTCSDCGKAFRDKSCLNRHRRTHTGERPYGCSDCGKAFSHLSCLVYHKGMLHAREKCVGSVKLENPCSESHSLSHTRDLIQDKDSVNMVTLQMPSVAAQTSLTNSAFQAESKVAIVSQPVARSSVSADSRICTE
Protein: Formin-3 (O94532)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:11696322, ECO:0000269|PubMed:12415007, ECO:0000269|PubMed:15809031, ECO:0000269|PubMed:16823372}. Cell tip {ECO:0000269|PubMed:11696322, ECO:0000269|PubMed:12415007, ECO:0000269|PubMed:15809031, ECO:0000269|PubMed:16823372}. Note=Found at the cell cortex and the growing tips of interphase cells. Localized to the septum region during cell division and upon cell division begins to localize to the new end, with some remaining at the older end. {ECO:0000269|PubMed:11696322, ECO:0000269|PubMed:12415007, ECO:0000269|PubMed:15809031}.
Interaction partners:
- Cell division control protein 42 homolog
- Actin-interacting protein 3 homolog
- Tip elongation aberrant protein 1
- Actin
- Cell division control protein 12
- GTP-binding protein rho1
- GTP-binding protein rho3
- Myosin-52
- Tip elongation aberrant protein Tea4
- GTP-binding protein rho5
Sequence:
MASKMPEGSPPTSRSIQSRNSSYSTSSNERIGTPSTISLSENSDLSKLQSTNDFESREDLSLTSDDNNDPEYVMCYNTVYHQKTKINDKLLSETEQLRKIYPLESRVFPKPTIVKEITNERTKRYTFYDDDAPLTNQHTVLDEATYNRILKRIDFFIEKVVEVPPTYHFLSLLNVQLRIQPIWWMDEFAERNGIESLLSALRNLGHYPERASKTPLESQIIQSLFHCLNSENCRRRYQSSAKCSVPGFNALGTIAETVLSKSLNSARMATFLLKFLCNKKGLSYFKAVIRAFEWLVEQKLSKTRFSAWMHSFNDVITGVRVCADSSPQAIVHMDEFEDTDCLIDYLVATLALIRDLCAAPPDLQLRCALRHELLSAGLQKAIDSLLKWRNRHVRDALQLLIKEHNADARRFRSGSDVNNVDRKCVKKQMNYREESHTPHGNTTRKTSTPVSNNRPTTPEQQAVWDVFQRIYTRFTGSEGSKESFIKLLEYFVTEPDNGKIQKSMQLLTHTLEALEGFKTAKADTNVGLTILSQRLLDKLGTAEEIAEYKTKYNGAMLENKHLKEQVESMLSQLNVGPRDPMQFLKKQLDELKAELNLRDNLLASMQREFETRYRAQIQAYNKLQSQMEHVQNSNEQHLQPGLLNKVSKSFDSVHRRNLSQDSLDAMTEQFSYHVEPNILSGSGIPVRVHTPSKTEDLDESFSGSEISSSPSPLLPDVSDTVEEQQKLLLKSPPPPPPAVIVPTPAPAPIPVPPPAPIMGGPPPPPPPPGVAGAGPPPPPPPPPAVSAGGSRYYAPAPQAEPEPKIDETSLTEEQKIQLEEARKQRKAADDAARAAIEKYTSIPSLRDLHKPTRPLKRVHWQRVDPLPGPNVFTKFCLNFDITAKVFIDNGLLDFLDEKFDNTPREDFVAVEISDQRSSLLPDTVEQNMAIILRSVSNMPVEDLVQKFLVEPDFLPASILYFDRASLASTNAYTDPFIPYSTDYTKKNPKEPTADVNSLSYFEKFFVLFVVNLRHYFQERMKALKFRSTLFGDLEILEVRMKEVIDTSDSIMEDKNFAEFFQVLLIIGNYFNEPYDRASAFSLYMIYRLETLRDSSSALTLMHYFDEIIRTRFPELLQAESTFKKIQSVSGYNIDAMVAGVDGAYDEFCDFQTSLKDGALSKCDQHHPDDKAYDILSEWLPEAKERIRNIKKLKTDMLTKLENTVKYLCEYDSIDKVRNSFFKNLNSFYEMYSIAKAENEERFEKEKRRIMSEDRDKLIRGRQKTSIVAKYRNKRELPEDSDDKQDTASKDKNSLETIDEKMEDASKIEGDAKTGDDNEMEDLDKMEDLEKPDYAEEKDPYITVMSELRSRIQNVPKRTVTVYSDEGVATLEPGAQGDDVVDKAKMILEKMEGHSQLLTSSANPDEEVLRAKLKAAERLQKPAIPRTRRKGHTEPKSAKSLLAELTNGSNASNLVENDRQKQ
Protein: AT4g14060/dl3070w (Major latex protein like) (Polyketide cyclase/dehydrase and lipid transport superfamily protein) (O23267)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock protein 70
- At3g17830
- Probable LRR receptor-like serine/threonine-protein kinase RFK1
- Similar to part of disease resistance protein domain family protein)
Sequence:
MATSGTYVTEVPLKGSAEKHYKRWRNENHLFPDAIGHHIQGVTVHDGEWDSHGALKIWNYTLDGKPEMFKERREIDDENMAVTFVGLEGHVMEQLKVYDTILQFIQKSPDDIVCKITMTWEKRADDSPEPSNYMKLVKSLAADMDAHVLKA
Protein: Intraflagellar transport protein A1 (Q57WZ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
- Intraflagellar transport protein 57/55
- Intraflagellar transport protein IFT88, putative
- Intraflagellar transport protein component, putative
- Intraflagellar transport protein 80
- Intraflagellar transport protein 56 homolog
- Uncharacterized protein
- IFT80/172/WDR35 TPR domain-containing protein
- C2H2-type domain-containing protein
- Intraflagellar transport protein 22
- Ankyrin repeat protein
Sequence:
MSFRELRSFAETMRLLGYPNLISMESFRNPNVELVADCLFWLIKRYEPSAEIVYEIEREADRVFFFKQVCEVALAKGRVKLNIKKLYQSDGNAVQEMLILANVLKKAMNTTGLEEIDHATLQQVIAQRNVQDAKRVQQLCSDLTNDGSSLFFLIEEETGQRGERQRVLSRATEVGEFERRLREVLKDVTTQVEQLQASIANLSADETTLEQKIESKKTQLERTQKRLKSLNAVRPAFMEEYEKHEGDMHSQFVIYLEQYRNLEYLEHELAKFNAAEDALLEEHETKLRVMRERLRREELNALRGEAGRKRGSRSENDGAPKIGGQGNGPEGNGSSAGPRVPKASGNMRDAALEGSSGSDSSGDSQEEEHIRPQGALGRPRPTAGPSTNPPPRAGPDGYDDSNAGGRSVRPGLSVRGSSPPDRNMRGPPPGGAGGGGMSDVDSDSSDDDDDDDDDSDIDTSEISIGSDDSGSESSSDL
Protein: Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] (Q62470)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:P26006}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P26006}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000250|UniProtKB:P26006}.
Interaction partners:
- Integrin beta-1
- Fibronectin
- CD151 antigen
- Integrin beta-4
- Focal adhesion kinase 1
- Thrombospondin-1
- Integrin beta-5
- Reelin
- CD9 antigen
- Integrin beta-6
Sequence:
MGPGPCRVPRAPGWLLRALALMVAACGRVAFAFNLDTRFLVVKEAVNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVGDDYTNRTGAVYLCPLTAHKDDCERMDISEKSDPDHHIIEDMWLGVTVASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVGKCYVRGNDLQLDPGDDWQTYHNEMCNSNTDYLQTGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKDWDLSEYSYRGSEEQGNLYIGYTVQVGNAILHPTDIITVVTGAPRHQHMGAVFLLKQESGGDLQRKQVLKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAVYVFMNQAGASFPDQPSLLLHGPSRSAFGISIASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSGGLLRQPQQIIHGEKLGLPGLATFGYSLSGKMDVDENLYPDLLVGSLSDHIVLLRARPVINILHRTLVARPAVLDPALCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFARSQSSVFHGFFSMPETHCQTLELLLMDNVRDKLRPIVIAMNYSLPLRMPDRLKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSNLQMRAAFLSEQLQPLSRLQYSRDTKKLFLSINVTNSPSSQRAGEDAHEALLTLEVPSALLLSSVRPSGTCQANNETILCELGNPFKRNQRMELLIAFEVIGVTLHTRDLPVLLQLSTSSHQDNLQPVLLTLQVDYTLQASLSLMNHRLQSFFGGTVMGEAAMKTAEDVGSPLKYEFQVSPVGDGLAALGTLVLGLEWPYEVTNGKWLLYPTEITIHSNGSWPCQPSGNLVNPLNLTLSDPGVTPLSPQRRRRQLDPGGDQSSPPVTLAAAKKAKSETVLTCSNGRARCVWLECPLPDTSNITNVTVKARVWNSTFIEDYKDFDRVRVDGWATLFLRTSIPTINMENKTTWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTDDY
Protein: ASNSD1 upstream open reading frame protein (ASNSD1 small/short open reading frame-encoded polypeptide) (ASNSD1-SEP) (L0R819)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23160002}.
Interaction partners:
- p53 and DNA damage-regulated protein 1
- Prefoldin subunit 6
- Protein UXT
- Prefoldin subunit 2
- Unconventional prefoldin RPB5 interactor 1
- Dynein axonemal assembly factor 10
- Asparagine synthetase domain-containing protein 1
- RNA polymerase II-associated protein 3
- Alternative protein MKKS
- PIH1 domain-containing protein 1
Sequence:
MPSRGTRPEDSSVLIPTDNSTPHKEDLSSKIKEQKIVVDELSNLKKNRKVYRQQQNSNIFFLADRTEMLSESKNILDELKKEYQEIENLDKTKIKK
Protein: Acyltransferase (Q21689)
Organism: Caenorhabditis elegans
Interaction partners:
- Lysophosphatidylinositol acyltransferase 10
- UDP-galactose/UDP-N-acetylglucosamine transporter srf-3
- O-acyltransferase
Sequence:
MRQDIQCLRGVAILLVLIYHLFPTLFVNGFLGVDIFFVISGFLMAQNLSKSKLVTVQDFFIFYYRRFRRILPLYYLVIFVTLAAVHLYLGDFWWYTNRRYSLASLFLVTNQLIIHDSADYFREFLADGTSLNAFIHLWSLGVEMQFYLLVPFIFFGLQFLKNDLLRLIASSLTTVIGFLCFAFINQQFAFNFMFLRLWQFSAGFMALFWKKISFYEYSEKLKPAKIELILPIAKGDLTTVCLSTIALCILPNKIELLALRPLVTMATAFIIASDSQDNQFLKSKTLCYIGDISYVIYLVHWPIIVLFLTASLRTHLFCILTILLASVVLHHIFEKQYLRMDWKALIPLLFVIVLSNAYLQNSIRVHSFWNNTYSLELQEVIQNNKMLLTDLAELQKMNAKNVCAVSNLDEPIGQKRVFGYCEYPKSHGNISVMMIGNSYVMTFSEPIRAQFHKNYSEYRYYSIGEGAAIYADSPGSHQALDIFKRNVAKFKPDVLFISARYSESVRLPIKHNDAYLKQMNENIEFYEKFVKKIYILDSHPLYNLNFLNFFMHYVVQRPDELESLHLNRQKADEQMRYVKKRFSMVKCKKCQFYDLSHVFVENDKYLTFDRGSMLSYVDNTIHLTKVGVELCEPVFKKIVKEIMNTL
Protein: Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein) (Q7Z7L7)
Organism: Homo sapiens (Human)
Function: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
Interaction partners:
- Cullin-2
- Elongin-B
- Protein zyg-11 homolog B
- E3 ubiquitin-protein ligase RBX1
- Elongin-C
- Kelch domain-containing protein 3
- Kelch domain-containing protein 2
- Kelch domain-containing protein 10
- Protein fem-1 homolog C
- Amyloid protein-binding protein 2
Sequence:
MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDRLVNEYVELVNAACNFEPHESFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFSHTLVSLSLFGCTNIFYEEENPGGCEDEYLVNPTCQVLVKDFTFEGFSRLRFLNLGRMIDWVPVESLLRPLNSLAALDLSGIQTSDAAFLTQWKDSLVSLVLYNMDLSDDHIRVIVQLHKLRHLDISRDRLSSYYKFKLTREVLSLFVQKLGNLMSLDISGHMILENCSISKMEEEAGQTSIEPSKSSIIPFRALKRPLQFLGLFENSLCRLTHIPAYKVSGDKNEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDRNIQVTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMESYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLSILNPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQREEVEERMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDIIKMATARQETKEMARKVIEHCSNFKEENMDTSR
Protein: Cuticular protein 49Ac, isoform D (E1JH44)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFTKSMLSFSLVVALFVVCHASPVPDNNGRSGSQESIGRYHHMPIPYRHVSDQRELGKYHHIPYPYDGGYGPYAGSNIPYVHDDRPYNHDLYTVSNAEFKVPEIPLEYGFPDHEPHHQPSTQY
Protein: Fumble, isoform A (EC 2.7.1.33) (LP11571p) (Q9VPG4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPEALHFTSIFDLIIKSAMPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSSTADEPPEKAPTSKHSTR
Protein: Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24) (Q6UX98)
Organism: Homo sapiens (Human)
Function: Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHSYDLGPCHNLQAALGPRWALVWLWPFLASPLPGDGITFQTTADVGHTAS
Protein: RNA-binding KH domain-containing protein (Q0WNX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSPDHRMSPDHRDSHRKRSRPQSDYDDNGGSKRRYRGDDRDSLVIDRDDTVFRYLCPVKKIGSVIGRGGDIVKQLRNDTRSKIRIGEAIPGCDERVITIYSPSDETNAFGDGEKVLSPAQDALFRIHDRVVADDARSEDSPEGEKQVTAKLLVPSDQIGCILGRGGQIVQNIRSETGAQIRIVKDRNMPLCALNSDELIQISGEVLIVKKALLQIASRLHENPSRSQNLLSSSGGYPAGSLMSHAGGPRLVGLAPLMGSYGRDAGDWSRPLYQPPRNDPPATEFFIRLVSPVENIASVIGKGGALINQLRQETRATIKVDSSRTEGNDCLITISAREVFEDAYSPTIEAVMRLQPKCSDKVERDSGLVSFTTRLLVPSSRIGCILGKGGAIITEMRRMTKANIRILGKENLPKVASDDDEMVQISGELDVAKEALIQITSRLRANVFDREGAVSALMPVLPYVPVAPDAGDRFDYDSRDSRRLERGNPYPGGYGSSGVSAEGYSPYGAPVGGSSSTPYGVYGGYASGRSSSSGLSSHSSTYRRRNYDY
Protein: Small ribosomal subunit protein eS19B (40S ribosomal protein S19-B) (RP55B) (S16a) (YS16B) (P07281)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS24A
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9A
- Small ribosomal subunit protein uS13A
- Small ribosomal subunit protein uS12A
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein eS26A
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS2A
Sequence:
MAGVSVRDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSSGNEMPPQDAEGWFYKRAASVARHIYMRKQVGVGKLNKLYGGAKSRGVRPYKHIDASGSINRKVLQALEKIGIVEISPKGGRRISENGQRDLDRIAAQTLEEDE
Protein: Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (F1R4Y7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis (By similarity). {ECO:0000250}.
Interaction partners:
- Sodium channel and clathrin linker 1
- Centrosomal protein of 89 kDa
- RAB3A-interacting protein
- C2 domain-containing 3 centriole elongation regulator.
- small monomeric GTPase
- non-specific serine/threonine protein kinase
- Centrosomal protein 128.
- Centrosomal protein 170Aa
- Intraflagellar transport protein 20 homolog
- Ninein
Sequence:
MDKMNPPALGQASALFPDLEPPGGVGKATVLLGGSTGLTSSDMEFQKMLIDERMRCENHKTNYQTLKVEHTRLQDQYTRAQNELKRLLSDRQVTQEKQQLLLAELRGELLDKTRDLEELKLQVLTPQRLELLRAQVQQELEAPIRERFNKLQEEAENYRSEYNKLRYDLTFLKSEFDHQKEEHARVLEERRIRHEADVARLEHDKEDLATQLQSGDPARDGKRVEALLREKAQLHQRLRGLEAEVTELRAERNNSGAQAENVQRIQIRQLAESQAAVKALEAEKQSIRMQLDRTESELRLSQEQNTLLTGKLHKAEREINSLNSQVEEMKHTHKLELSNVKLECVRSKGELERERDMLQCQVEGLQSDIEVMKSALERNKELISEKEREMVRRVQAAREEEIHKMATLQEEKLELENRLSELEQQKALQEVTGNSQKEEWEERLRAAQLGEESVRKELQNLRTKVQQQGQQLEELETLKAENADLRQQIAELNLQVGTLSHSESELLDTNNRLRESLERVREDLRSARTQMERTQQEAERLVEERRVEWLEEKHKLQDIEAELREKYSQAKERLQRAAFAQKKRKTMTELKENKLKDKIQLLEAKIAELEIEAKHAQLSKRLRELQRRHNEFRRLLLGNQMTSSTPLAQSLLIPNESIFSNIQVSEEQHQRELCVLRRRLEELENSQQQQLEELAAPLDRDRERLSSPRDALPDLS