wanglab/gogpt-training-data huggingface dataset:
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Q9CQ68)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase iron-sulfur protein 5
Sequence:
MAAWRLSLCARSLSAIRRLQAAPLCWKSSSSRAVVARSAAARKEQEEPTVQWMEDPDPEDENVYLKNPHFHGYDDDPKVDALNMHAVFFFGFSIALVLGTTFVAYVPNYKMIEWARREAAMLVKHREASGLPIMESNYFDPTKINLLEDD
Protein: Intraflagellar transport protein 56 homolog (Putative IFT protein C3) (Q57ZL2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Component of the intraflagellar transport (IFT) complex required for transport of proteins in the motile cilium.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:20923419}. Note=Localizes around the basal bodies and the flagellum base. {ECO:0000269|PubMed:20923419}.
Interaction partners:
- Intraflagellar transport protein component, putative
- Uncharacterized protein
- Intraflagellar transport protein IFT88, putative
- Intraflagellar transport protein 57/55
- Intraflagellar transport protein A1
- C2H2-type domain-containing protein
- Intraflagellar transport protein 22
- Intraflagellar transport protein 80
- IFT80/172/WDR35 TPR domain-containing protein
- Ubiquitin fusion degradation protein, putative
Sequence:
MLSTSGRVKRKNAAPLQKVGQTKTSVVDQLEEALQQRDFSKATTVLEFYKTTNQPVGDLPINPWLAYSAFHMNDVSKALDVYKELLSLDGCDPMHYIHMGCCHFVNGSYAEAEECALKGPDCSLQTRLLFHIAQKTYDEDKLLVYHQKLKETVEDQLSLGAVHFYRGHFQEAIDVYKRILLETREYIALNVYVAMCYYKMDYYDVSLEVLNVYLQSHNNSATAINLKSCNHYRLYNGKAAEAELRVLIDLQRSTYNVENDIVKHNLVVFRNGEDALQVLPPLLNVVPEARLNLVIYHLRHEQIEEAYELIKDLEPVASTEYILKAVVNAFIGQKLDSEEHLKTTREYFNLIGSAQSECDTIPGRQCMASYFFILRDFPNVLIYLRSIKPYFLNDDTFLYLHGIACAATGSFAEAEESLTAVRSEKVKAEFSYMSWLMRAHIMNKHAKRAWDIYLKMETSAESFNILQLMANDCYKVCAFYYAAKAFDVLERLDSAPEYIEGKKGACIGVFQQVFAGQEPADSLFDVMKMLDMSVQQHANDPKVSQQFESILKVIKDWVKESKLKKK
Protein: Chromosome 16 open reading frame 33 (Small nuclear ribonucleoprotein U11/U12 subunit 25) (Q4TT61)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQSATVLDLKKAIQRYVQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK
Protein: Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36) (Q9QWH1)
Organism: Mus musculus (Mouse)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Subcellular location: Nucleus {ECO:0000269|PubMed:28900001}. Note=Co-localizes with SAMD7 in nuclear polycomb bodies. {ECO:0000269|PubMed:28900001}.
Interaction partners:
- Polycomb group RING finger protein 2
- E3 ubiquitin-protein ligase RING2
- Polycomb complex protein BMI-1
- E3 ubiquitin-protein ligase RING1
- Chromobox protein homolog 8
- Chromobox protein homolog 2
- E3 SUMO-protein ligase CBX4
- Chromobox protein homolog 7
- Polyhomeotic-like protein 1
- Polycomb protein EED
Sequence:
MENELPVPHTSNRASVTTNTSGTNSSSGCISSSGGGGGSGGRPTAPQISVYSGIPDRQTVQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVANRQGSTPGSSVSSQAPAQSSSLNLAASPAAAQLINRAQSVNSAAASGLAQQAVLLGNTSSPALTASQAQMYLRAQMLIFTPTATVATVQPELCTGSPARPPTPAQVQNLTLRTQQTPAAAASGPPPTQPVLPSLALKPTPSSSQPLPAPPQGRTMAQGSPAGAKPSGTDNAPETLKAGDGNCNMEGRPGPGRAVPAVATHPLIAPAYAHLQSHQLLPQPPAKHPQPQFVAQQQPQPPRPAPQVQSQPQLASVSPSLALQSSPEDHALPLGSVTQALPLQCSTTHVHKPGNSQQCHLPTLDTGSQNGHPEGGSHPPQRRFQHTSAVILQVQPASPVTPQQCAPDDWKEVVPAEKSVPVARPGPSPHQQAIIPAIPGGLPGPKSPNIQQCPAHETGQGIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKPPQQDHTTTTDSEMEEPYLQESKEEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKAGTTTHNRRRASKASLPTLTKDTKKQPSGTVPLSVTAALQLAHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLDLPDMHMRDLVGVGHHFLPSEPTKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKDS
Protein: LmbJ protein (Q54363)
Organism: Streptomyces lincolnensis
Interaction partners:
Sequence:
MSDHDFAKLYGDKIADVYDVWPGDAGPPPDADRAAPFLAALANGRPALELGVGTGRVAVPLAESGVEVHGVDSSARMLEILKEKSGGAVHGHQQDFGRLDLGERRFGLVFALFNTLFCLLTQDEQIACLRSAANCLETEGLLVLQCLNPKSLPDGSDVALVELEHDGVHLDVSKHDPVAQTLTAHHIVLSESGARFFPYTLRYSHHTELDLMAARFAGFELRSRHADFDGAAYRPDSRYHVSVYARAHGD
Protein: Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70) (P28236)
Organism: Mus musculus (Mouse)
Function: Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1325220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000305|PubMed:1325220}.
Interaction partners:
- Lens fiber major intrinsic protein
- Gap junction alpha-3 protein
- Beta-crystallin B2
- Alpha-crystallin A chain
- Gap junction alpha-5 protein
- Gap junction beta-2 protein
- Gap junction alpha-1 protein
- Beta-crystallin B1
- Tight junction protein 1
- Gamma-crystallin D
Sequence:
MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDQASIRKSSSSSKGTKKFRLEGTLLRTYVCHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLGMKGIRSAFKRPVEQPLGEIAEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMSRSYQETLPSYAQVGVQEVEREEPPIEEAVEPEVGEKKQEAEKVAPEGQETVAVPDRERVETPGVGKEDEKEELQAEKVTKQGLSAEKAPSLCPELTTDDNRPLSRLSKASSRARSDDLTI
Protein: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Q5VX20)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQPLLGQACLRTVCHIFSKFSPY
Protein: Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (A0A0R4IZ84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (By similarity). Required for normal embryonic development.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q86US8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q86US8}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q86US8}.
Interaction partners:
- Regulator of nonsense transcripts 1
- Serine/threonine-protein kinase SMG1
- Nonsense-mediated mRNA decay factor SMG9
- Uncharacterized protein.
- Regulator of nonsense transcripts 3B
- Nonsense-mediated mRNA decay factor SMG8
- Nonsense-mediated mRNA decay factor SMG5
- Regulator of nonsense transcripts 3A
- SMG7 nonsense mediated mRNA decay factor.
- 5'-3' exoribonuclease 1
Sequence:
MADELERVRISAAELRAQASSFNIHGDDVKDLREEGKKQRQRDSKRPDLQLYKPGVGHPNRRMDSVEGAGSDTLIQPDGFGNDPKMSDESPTSPGCSYMPGTGNEDYLNDHSKPETNHKTDGHIGGDKHKLVDENAVKIIERAGTPKSPKQSRKMRKPDRQIYQPGGRRSQGNKEVGASKELDRDRSREEEVDGKSIETPLKCEKEEKRKNRRGKNDRKKQASVETPSANKTENAVENISNKVSNLHLETVESKDRDRQDDTNQIKHSEEGRKIQTGGANRGMGEDKKKERGNGKSRPGKEKGNNQVFDKKEEGEAGGKASEAPHLEGRKQRNFGAKEASRDQNLNHEKQQGNRPKEKGKPSERTDSKRVNAASKRYSQSDIRRPRNRTYSTSSASSGTSMDGLAEAERLKAEGQQFSARTLERATGQREFVRGGQTRSRRRTARTLSSTDSLEENEVWEREGRRSRAAEEAKSSTRKEGGILRVSLDKREEQASRKSTRGRGRGILVLPAHTDLTQTPDPAPPLGGMRGGMGLGRGRGGRGGGTRRLWDPNNPDKKPALVSSQQSQHASQHQALYLQQGGCGPLHFLDTDDETVGSPPVRQGEFFQNQQAAAMAYYKFQNSDNPYCYPVSANSPNTPPRYPYPYQIPYQIPGSNGMYPASAMTSFYGPYGQGGPGYPSPTVSALTPEEAEVQTRGELGKFLRLADSQELQLSNLLSRERLSQEGLERMAQLRAELLTIYERVILTDIEFSDSQNVDQTLWKNVFYQVIERFRQLLKDQNSDTAPQIKTMLMTILEEGAVFFDSLLQKLQSVFQFKLQDYMDCMAIRARPLRKTVKYALISAQRCMICQGDIARYREQASESANYGKARSWYLKAQQIAPKNGRPYNQLALLAVYTKRKLDAVYYYMRSLAASNPILTAKESLMSLFEEAKRKADQVERRLKQDSDGSAHGPKGHTGGRRGEDAARVEIWIRPSEVSGTSRPTGSESGKDSEQDGELGALSASDLNKRFILSFLHAHGKLFTKVGMESFPAVANRVLLEFRALLQHSPSPLGSTRMLQIITINMFTIYNAQIRAKGQGETRSALEEQAISLGLAMFGLLVQRCTELLKETPTEPIPAEELGEFDEMDDEEGMVRVSVFPHDLRELLPSMKVWSDWMLGHPEKWNPPPCSMQGSPDVWQCLADLCNSFSRVYHGEVLLYKADADGEGDEELRVLQLEEDKMLSGFVPLLAAPQDACYTDQGTDAAIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYISMAAPLTPSINTENKAQEQEDDVIVEESSLSASEGEIDGEMEGDGSEDDIRELRARRHALAHKLAQQQKRRDKIQAVLQTGGQLEIEVRPFYLVPDTNGFIDHLEGLRKLLACGTYILVVPLIVITELDGLAKGQDSREGVGNGAHARQVQDRARAAVMFLEKAFESRDPSIRALTSRGNTLESIAFRSEDTSGQKGNNDDVILSCCLHYCQDKAKDFMPAERNGPVRLRREVVLLTDDRNLRVKALTRNVPVRDIPAFLIWAKVG
Protein: Spectrin beta chain (G5EG85)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MATVDGNSGAYTQDEDYDDNSSARLFERSRIKALADERELVQKKTFTKWVNSHLVRVSCKVQDLYMDMRDGKMLLRLLAVLSGERLPKPTPGKMRIHCLENVEKGLQFLRNQHVHLENLGSHDIVDGNSRLTLGLIWTIILRFQIQDITFEDADNHETRSAKEALLLWCQMKTAGYPNVNVKNFSTSWRDGLAFNALIHKHRPDLVDYDNLQKSNALYNLQSAFDTAENQLGLAKFLDAEDVNVDQPDEKSIITYVVTYYHYFNKLKQDNIQGKRIGKVINELMENDKMINRYETLSSDLLEWINAKIQLLNERHFENNLEGVQRQLTEFNDYRTQEKPPKFDEKGELEVLLFTLQSAMRANNQRPFVPREGKLIADINRAWQSLEKAEHERELVLKEELIRQEKLEQLAARFNRKAEMRETWLTENQRLVSQDNFGNDLSSVEAATKKHEAIETDIFAYEERVQAVVAVAGELEAENYHDQAKINERKENVLQLWNYLFQLLLARRVRLELSMAIQKIFHDMLLTLDLMDDIKSRLLSEDLGAHLMDVEDLLQKHALLESDINIIGERVNNSIAQAQRFRNPDGPDGSGYKPVEPGTIDERSDVLQKRYKELLDLAAERKRRLEDNKRLCQFWWDVAELEHGIKEQEQVLSSTDTGRDIVTVSHLLAKHKNAENNLRDLEKYLDRLDVSGKELQDESIPGSDNIPPRLAEIRDYINKLKELSASRKERLAGGVEYYQFFTDADDVDRYLYDTLRVMSSEDVGKDEGTVQLLLKKHDDVHDELQNFDQHIKVLHAKAESLPQEAREHPDIRQRLDTTLKQKAELENLSQLRKQRLIDALSLYKLYSDADSVESWIDEKGKLLATLVPGRDIEEVEIMKHRFDTLEQDMKNQEAKVTNVNDLARQLLNVEHPNSDDILHRQNKLNARWAQLRDMVDQKRNELERAHRLETFRIDCQETVTWIEDKTRVLEDSDALTNDLSGVMKLQRRLSMMERDLGAIQAKLDSLHKEADDIERERPQEAQAIREDIKRIHQVWDILNKKVREHEAKLDEAGDLQRFLRDLDHFQAWLTATQRQVASEEEPQSLAEAEQLLNQHAAIREEIDGYAEDYKKMRAMGDRVTQDQTDPQYMFLRQRLAGLQEGWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEVMLSQQENYLAKDDIPQSLEQAENQLKRHQDFITTMDANDEKIRAVGMFGDQLCQDGHYAADKIHKKARNIDERRGANREKAQEVLKKLKDALSLQQFLSDCDELREWIEEKMIRAQDETYRDAKTITSKFVRHQAFQSELAANKERLDQLKHAAINLGDDKPEYHGTIDPQIEELATQWDELEKTTEEKGQKLFDANRQQLYVQSIADMKEWATQLENEMTREDQPGDLTTVNVAMQKQHLIETEMIKKAQHIDQLMEMEPQLEELHPDELENIKAHRLAVQEQLQRLQAPLDDRRKALERKKAAFQFGRDVDDEKLWISERLVLAKAQNLGESLPDCHRLQKNLQLLSNEIDNHEPWINQICNNGQELIDEGHANGPAFEKKIQELRSAWQELKEAVKDRKGDLGESEKAHQFLYDCGEAEAWMSEQELYMMQDERGKDEFSTKNQIKKHERLQSDIDKFADTIRALATKAHKFVEEKSPLTEQIQVRQAQIEKLYAGLQDLSKERRKRLEETLELYALHREIDDLLQWIADKEVVAGSQENGQDYEHVQMLQERFQQFARDTENIGSERVANANDGCDTLIGHGHTDAPTIALWKDSLNEAWENLLELMDTRAQILEASRLLHKFYHDCRDCLSRIMEKTHAMPDDLGRDSSSVGALSRKHQNYLKDIAAIGEQVAQIERDAAELRDGYAGDKALDIGSRESEVVKAWRHLRGLCDARTSRLMDTSDLFKFMNMVRDLLLWMDEVKREMNSQERPKDVSGVELLMNNHQSLKAEIDAREENFNACISLGRDLLNRKHYASSEIEKKLIKLTTERAEMMRRWEDRWEYLQLILEVYQFARDAAVAESWLFAQEPYLISKEYGRNLEETIKLIKKHEAFEKSAFAQEERFLALEKLTTFELKETQHREEETAKRRGPAHIGSPSRSTPAAETSFGAQDDGAKQGEAFEGTLIRKHTYESLDRKAANRSWEKLYAVLRQNELSFYKDPKHRDESVHGEPPMALPGCSVNVASDYQKKKNVLSLRLPIGAEYLFQCGSEEDMQRWLTELQVATGQAQLEEASRSQTLPAEGSATKKKGGFFSRGKK
Protein: GH07623p (Q8MRP6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPKFSENSWDASAGTGRSEGRQLHFDIKQDAITFEGTERKNSVSETTSTGLQILSIEDEIMSEVKANIDDANNASIESIAPEPVQVPAPPKVNPPPPPRPASPKVEPPPPAPPGVESPPGPQPPASPRFDPPPPHTIEPPPPPAPPTLVPPPPPAPPTIKPPPPPAPPTVEPPPPPPPAPPTVEPPPPPPPAPTKVEPPPPPAPAEVEPPPPPAPTELEPPPPPAPPKVELPPPPAPPKAEAAITPRRAKGSNGFITELAVTPKESETRDKPHNVNTDVKEDEQPATTEDKQDKPLELGLDAPKDAVSTASESTESPTSTSSQSKSHSKSRDKEKEKDRRHHRHSDDKHRRRSTDRDRDRSRDKSHSKHSSSSSSKHSSSNSSSSKHKSSSSKNDKSSSSSSSRSNRESSSSKRSGTTSSSRHESSSHKKHKSSSSSSRSERDKGKEKDKEREKDSQSRSHHSSSSSSSSSRRKDHDRGRDRDRNKSNTSGSAENKAIHDDHSESKEKYKQRRGSDSNDEGKPPSSGGPAKNSQPEDSAATMKSDAPVENANGTNGNSNGSTNGACDNVSGVVIVSDILQQSTSSFVELTAGSQSHDRAESSKHEPEDIDGKEADNQPEKTELEARQDECASQNEVPTVEPQTLADSVPDLPAKESMDTLEDEKVETNVEENKSEEESKPENPPEECVDEPAQVGDVEDPPQDADKPATPVPISNEQSDEFSADFVTHFEENTDEFRTRLQLINQLIEDRKNLLNRLSEDGTQEEAVDIRALRRSLSKRRRSSMQEQHRVERETTPPQPRSPSSSSTAGSPAKRLRQDEPKSSPTPSDASINSKENEALEKQEHAV
Protein: Tetratricopeptide repeat (TPR)-like superfamily protein (F4JFR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAALIRCCSSFSHTSGGQPPPRDKSRAPEIGKFATSIGYSVVRKPGDHPPFSKIIHSSSQPKERQGKGILQTPFASVGSLDKFSAFEVGIGRLKLPVMAVLLTNSLQMATPLEALAAEICEPESSMFSMPILLLVALIGATVGGLLARQRKGELQRLNEQLRQINAALRRQAKIESYAPSLSYAPVGARIPDSEIIVEPKKQELISKLKTGKTFLRNQEPEKAYTEFKIALELAQSLKDPTEEKKAARGLGASLQRQGKYREAIQYHSMVLAISKRESEDSGITEAYGAIADCYTELGDLEKAGKFYDTYIARLETD
Protein: Forkhead box protein Q1 (HFH-1l) (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) (O70220)
Organism: Mus musculus (Mouse)
Function: Plays a role in hair follicle differentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MKLEVFVPRAAHGDKMGSDLEGAGSSDVPSPLSAAGDDSLGSDGDCAANSPAAGSGAGDLEGGGGERNSSGGPSAQDGPEATDDSRTQASAAGPCAGGVGGGEGARSKPYTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSHRTTVSASGLRPEEAPPGPAGTPQPAPAARSSPIARSPARQEERSSPASKFSSSFAIDSILSKPFRSRRDGDSALGVQLPWGAAPCPPLRAYPALLPAAPGGALLPLCAYGASEPTLLASRGTEVQPAAPLLLAPLSTAAPAKPFRGPETAGAAHLYCPLRLPTALQAAAACGPGPHLSYPVETLLA
Protein: Bifunctional glycosyltransferase pgtA (FT85) [Includes: N-acetylglucosamine 3-beta-galactosyltransferase (EC 2.4.1.-); Alpha-1,2-fucosyltransferase (EC 2.4.1.69)] (Q54QG0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Bifunctional protein composed of 2 glycosyltransferase domains involved in glycosylating skp1. The N-terminal part catalyzes the transfer of a galactose residue to GlcNAc-skp1 in a beta 1-3 linkage. The C-terminal part catalyzes the transfer of a fucose residue to Gal-GlcNAc-skp1 in an alpha 1-2 linkage.
Interaction partners:
- UDP-galactose:fucoside alpha-3-galactosyltransferase
- Prolyl 4-hydroxylase subunit alpha
- GDP-mannose 4,6 dehydratase
- Cullin-2
- Cullin-5
- Cullin-1
- Elongin-C
- SCF ubiquitin ligase complex protein SKP1b
Sequence:
MNDSPIISVVLPFLIKDNDDKSLNYQGINNLIISIDSIIEQTFKEWELILVDDGSNNEILEQLLSKRYSTDNRIKFIINKENKGIVKSLNDAILNHCSPTSKYIARMDSDDISHPTRLQSQLKYLQSNETIDILGCPIKMFNNNKLIEILNNNNNNNNINNNVKELINIINNEESFKFIQHPDKDILMWSMFFNCCIVHPSVIFKRSIFTIEHCYEENNQFPFIEDYLFWLKSLIMKGLNISNIQSSTPLLYLRKHNNSISFKNIEKQKDSTANASCYYLNILFKRFNIDSEIIQNSSLSMKEIIQFFQLSPSSLSKINNISIELFEFAFKYLELIEKSCTKQQPNYSNSIKDAANEKMGELVSLCLSNYPNNQKSSLLWEKWLSRNPTSQLLSLLSNLNVKSSTTIINNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNSILNFISGINSNKINTPKSNNNKFKENGIRIICFSKDRAFQLKEYLRTFFKYLKNDDNGNDKFEIIVDVLFTYSNEKFKNSYQLVIESFPQVNFIKEENFTDQLINLVQKTNKLEYVMFSVDDILYYNEFNLKEYCLSLNSEPLALGFYMKLNKNITYCHTCNQDITIPLNSNTISRTENNFKYLKWNRNDNDCKKDWNYPWDLCSTIYRCNDIDSIINGIVKYYGIRNGINHPNRFEFNGNRPIIQKQIYQNKPYCLCLSDHYSPMSVVTINRVQDVYDNPIYDQTLSLDDLDQLLYSNKSLNDEKYKENSLSLNFKSVHIGELFIS
Protein: ESX-1 secretion-associated protein EspH (O69732)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- ESX-1 secretion system protein EccA1
- ESX-1 secretion-associated protein EspF
- ESX-1 secretion-associated protein EspE
- ESX-1 secretion-associated protein EspG1
- ESX-1 secretion system protein EccCa1
- ESX-1 secretion-associated protein EspL
- ESX-1 secretion system ATPase EccB1
- FHA domain-containing protein
- ESX-1 secretion-associated protein EspB
- ESX-1 secretion system protein EccCb1
Sequence:
MVDPPGNDDDHGDLDALDFSAAHTNEASPLDALDDYAPVQTDDAEGDLDALHALTERDEEPELELFTVTNPQGSVSVSTLMDGRIQHVELTDKATSMSEAQLADEIFVIADLARQKARASQYTFMVENIGELTDEDAEGSALLREFVGMTLNLPTPEEAAAAEAEVFATRYDVDYTSRYKADD
Protein: Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (N-system amino acid transporter 1) (NAT-1) (Q8IZM9)
Organism: Homo sapiens (Human)
Function: Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:G3UVW3}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:G3UVW3}. Note=Colocalizes with synaptotagmins and SNAP25. {ECO:0000250|UniProtKB:G3UVW3}.
Interaction partners:
Sequence:
MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFDWINK
Protein: Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) (O88831)
Organism: Rattus norvegicus (Rat)
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96RR4}. Cytoplasm {ECO:0000250|UniProtKB:Q96RR4}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96RR4}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000250|UniProtKB:Q96RR4}.
Interaction partners:
- Calmodulin-1
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Protein kinase AMP-activated non-catalytic subunit gamma 3
- Protein kinase AMP-activated non-catalytic subunit gamma 2
- 5'-AMP-activated protein kinase subunit beta-1
- 5'-AMP-activated protein kinase subunit beta-2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- Serine/threonine-protein kinase STK11
Sequence:
MSSCVSSQPTSDRAAPQDELGSGGVSRESQKPCEALRGLSSLSIHLGMESFIVVTECEPGRGVDLSLARDQPLEADGQELPLDASEPESRSLLSGGKMSLQERSQGGPASSSSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTVESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTREWEPLSEPKEARQRRQPPGPRASPCGGGGSALVKGGPCVESCGAPAPGSPPRTPPQQPEEAMEPE
Protein: Dihydrofolate synthase/folylpolyglutamate synthase (EC 6.3.2.12, EC 6.3.2.17) (Q8IE69)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative
- Coronin
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- aminodeoxychorismate synthase
- GTP cyclohydrolase 1
- Homocysteine S-methyltransferase, putative
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast
Sequence:
MEKNQNDKSNKNDIIHMNDKSGNYDKNNINNFIDKNDEHDMSDILHKINNEEKKYEEIKSYSECLELLYKTHALKLGLDNPKKLNESFGHPCDKYKTIHIAGTNGKGSVCYKIYTCLKIKKFKVGLFSSPHIFSLRERIIVNDEPISEKELIHLVNEVLNKAKKLYINPSFFEIITLVAFLHFLNKKVDYAIIETGIGGRLDATNILTKPEVIVITSIGYDHLNILGDNLPIICNEKIGIFKKDANVVIGPSVAIYKNVFDKAKELNCTIHTVVPEPRGERYNEENSRIALRTLEILNISIDYFLKSIIPIKPPLRIQYLATEQIQHIKKKFSPDNLEHNVQYPLAVILDVGHNETAIDRLCTDINYFHKGQNIRICISITKPRNLSVFHPFIAQFGDTLKDIFYLPSLNERTYDFEEIVEMLNNEEEIKNEIKELILSSSKKVGKWLAHEKQGNINEEDALKLYKRGCIPLIIKNAFLECCKDNSILLVCGTFFVFDEVLNVFDIHSDMQDTIFMNEPSLV
Protein: RING-box protein 1 (Rbx1) (Ce-rbx-1) (Q23457)
Organism: Caenorhabditis elegans
Function: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-4
- Cullin-3
- Cullin-2
- RNA polymerase II transcription factor SIII p18 subunit
- Cullin-6
- Elongin-C
- Elongin-C
- DNA damage-binding protein 1
- Cullin-5
- Cullin-1
Sequence:
MAQASDSTAMEVEEATNQTVKKRFEVKKWSAVALWAWDIQVDNCAICRNHIMDLCIECQANQAAGLKDECTVAWGNCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Protein: Zinc finger protein 24 (Hypomyelinated CNS protein) (Zinc finger protein 191) (Zinc finger protein ZF-12) (Q91VN1)
Organism: Mus musculus (Mouse)
Function: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:20080941}.
Interaction partners:
Sequence:
MSAQSVEEDSILIIPNPDEEEKILRVKLEEDPDGEEGSSISWNHLPDPEVFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVAILPKELQTWVREHHPENGEEAVAVLEDLESELDDPGQPVSLRRQKREVLVEEITSQEDAQGLPSSELDAVENQLKWASWELHSLRHCDDDATTENGALAPKQEMASAGESHEGPGTLNIGVPQLFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKPYECVQCGKSYSQSSNLFRHQRRHNAEKLLNVVKV