wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor-like kinase TMK3 (EC 2.7.11.1) (BARK1-like kinase 2) (Leucine-rich repeat receptor-like kinases TMK3) (Transmembrane kinase 3) (Q9SIT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin signal transduction and cell expansion and proliferation regulation.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- MIF4G domain-containing protein
- At4g27620
- At4g12840
- Pentatricopeptide repeat
- F-box protein At1g70590
- Probable diphthine methyl ester synthase
- Protein involved in starch initiation 1
- Protein ENHANCED DISEASE RESISTANCE 2-like
- Tetratricopeptide repeat
- At3g27230
Sequence:
MSNSHLGTLCFIISLLGLANFSLSQTGLDDSTMQSLKSSLNLTSDVDWSNPNPCKWQSVQCDGSNRVTKIQLKQKGIRGTLPTNLQSLSELVILELFLNRISGPIPDLSGLSRLQTLNLHDNLFTSVPKNLFSGMSSLQEMYLENNPFDPWVIPDTVKEATSLQNLTLSNCSIIGKIPDFFGSQSLPSLTNLKLSQNGLEGELPMSFAGTSIQSLFLNGQKLNGSISVLGNMTSLVEVSLQGNQFSGPIPDLSGLVSLRVFNVRENQLTGVVPQSLVSLSSLTTVNLTNNYLQGPTPLFGKSVGVDIVNNMNSFCTNVAGEACDPRVDTLVSVAESFGYPVKLAESWKGNNPCVNWVGITCSGGNITVVNMRKQDLSGTISPSLAKLTSLETINLADNKLSGHIPDELTTLSKLRLLDVSNNDFYGIPPKFRDTVTLVTEGNANMGKNGPNKTSDAPGASPGSKPSGGSDGSETSKKSSNVKIIVPVVGGVVGALCLVGLGVCLYAKKRKRPARVQSPSSNMVIHPHHSGDNDDIKLTVAASSLNSGGGSDSYSHSGSAASDIHVVEAGNLVISIQVLRNVTNNFSEENILGRGGFGTVYKGELHDGTKIAVKRMESSVVSDKGLTEFKSEITVLTKMRHRHLVALLGYCLDGNERLLVYEYMPQGTLSQHLFHWKEEGRKPLDWTRRLAIALDVARGVEYLHTLAHQSFIHRDLKPSNILLGDDMRAKVSDFGLVRLAPDGKYSIETRVAGTFGYLAPEYAVTGRVTTKVDIFSLGVILMELITGRKALDETQPEDSVHLVTWFRRVAASKDENAFKNAIDPNISLDDDTVASIEKVWELAGHCCAREPYQRPDMAHIVNVLSSLTVQWKPTETDPDDVYGIDYDMPLPQVLKKWQAFEGLSQTADDSGSSSSAYGSKDNTQTSIPTRPSGFADSFTSVDGR
Protein: Membrane-spanning 4-domains subfamily A member 12 (Q9NXJ0)
Organism: Homo sapiens (Human)
Function: May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Membrane-spanning 4-domains subfamily A member 6E
- Putative membrane-spanning 4-domains subfamily A member 4E
- Zymogen granule membrane protein 16
- Guanylin
- Calcium-activated chloride channel regulator 4
- Aquaporin-8
Sequence:
MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPNMYESNPVTPASSSAPPRCNNYSANAPK
Protein: Translocator outer membrane protein PopD (Q9I323)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Translocator protein PopB
- Type III secretion protein PcrV
- Regulatory protein PcrH
- Regulator in type III secretion
- Type III secretion outer membrane protein PopN
- Secreted exoenzyme S
- Exoenzyme T
- Type 3 secretion system needle filament protein
- Type 3 secretion system chaperone PscE
- Type 3 secretion system chaperone PscG
Sequence:
MIDTQYSLAATQAAIPSEPIAPGAAGRSVGTPQAAADLPQVPAARADRVELNAPRQVLDPVRMEAAGSELDSSVELLLILFRIAQKARELGVLQRDNENQSIIHAQKAQVDEMRSGATLMIAMAVIAGVGALASAVVGSLGALKNGKAISQEKTLQKNIDGRNELIDAKMQALGKTSDEDRKIVGKVWAADQVQDSVALRAAGRAFESRNGALQVANTVIQSFVQMANASVQVRQGESQASAREGEVNATIGQSQKQKVEDQMSFDAGFMKDVLQLIQQYTQSHNQAWRAAAGVV
Protein: Ectoine dioxygenase (EC 1.14.11.55) (Ectoine hydroxylase) (E1VA04)
Organism: Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
Function: Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.
Interaction partners:
- L-ectoine synthase
- Ectoine hydrolase
- Diaminobutyrate--2-oxoglutarate transaminase
- L-2,4-diaminobutyric acid acetyltransferase
- YcgM family protein
- Aspartokinase
Sequence:
MSVQTSSNRPLPQANLHIATETPEADSRIRSAPRPGQDPYPTRLSEPLDLPWLNRREPVVKGEEADGPLSAAQLDTFERQGFIFEPDFLKGEELEALRHELNALLARDDFRGRDFAITEPQGNEIRSLFAVHYLSRVFSRLANDERLMGRARQILGGEPYVHQSRINYKPGFEGKGFNWHSDFETWHAEDGMPAMHAVSASIVLTDNHTFNGPLMLVPGSHRVFVPCLGETPEDHHRQSLKTQEFGVPSRQALRELIDRHGIEAPTGAAGGLLLFDCNTLHGSNANMSPDPRSNAFFVYNRRDNRCVEPYAASKRRPRFLAHEPDEAWSPDG
Protein: UL6 protein (Q77CB1)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MAECERVVSERALNLAGSARNPGAPGPPGEWVRIHPTRGTRLFKEILLGELGYTEGQGVYSAVRCTETVIRQVQATILSTTLNAARYEDVARDWRAYTRARGLRAADIAARYGPRGEAEVVRLAEHVFDTWRRTLQMSLVECVRGVAAAFPAGGAGSPASFARYVDWLVCLGLVPLRRIGLAVPAPSRRRGPLPALARAGPAPGRCRRVLAECEAFAADLLRCAGAVTVLDYDRTEILYNFRKKQFAVREAVTGEEGECFVLWAPVWRGGDVLFESPMQRLHGEVLACHALREHARLCQLLNTVPLKVLVGRRAEALRAKPPGAPSVEKLLGEGEDAAASSSAARLIKLIVNMKGMRHIGDISETVRSYLDDTAAGLFDVSDVDTSQPGFGAAGGRAGGGADSRSRTAFRASVVHSINGMLEGYVSNLFKTIESLKGANRDLADKLRAKSASCRRLESARCWPPKRPTPRAGGAGRRPARVRCRRAPRTAELGHEVIDISGLMGPDSYVANSFQSRYIPTYADDVERLSRLWEQELLRCFKLARTANNQGQEVSVVYSNSSISLILAPYFFSVLRVRRFGFLIAHQEACRSEEELCGAVFKKTRLETYLAELAAIFTADARRALQLGLASRGARERSGSRSRSRSRSRERGRSKSRSRSRSRSREEKRRRERREDGRGVRRTYAGRAP
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (Q2LIP6)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
RVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRTASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPTDFRIELRIKRDRGYHTEVRKNTQDGSYPIDAVSMPVRNVNYSIFACGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENKNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKHLPMDLPKNKF
Protein: RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Q9VDG2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Participates in receptor endocytosis during interphase, is also involved in mitotic processes when endocytosis is switched off.
Interaction partners:
- Ras-related protein Ral-a
- GH06923p
- Adaptor protein complex 2, mu subunit, isoform A
- Matrix-remodeling-associated protein 7
- AP-2 complex subunit alpha
- non-specific serine/threonine protein kinase
- AP complex subunit sigma
- Cyclin-G-associated kinase
- Exocyst complex component 8
Sequence:
MDFDSPEEKEFPGLYASEAADAKSRKSKEESDFSEDHDHSKKDLLIGRRKDKKEKGKDRGYAALEGESSPEEELDTKSPSKSKKSKTFKFTSSKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKEKERDKEKDRDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAAEEVLALGYPVFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDHLKCEQIYKIEPIKTRLMHFKRLYNNREHDSAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPLTSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFEKKQEKTAEEVDNSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAPNDFTIDPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARIVAERNEVYRLKQLYEQQSINSQMASLASGSQAPPESDYERIIEHYTRENALLEHKKNMLGMELKEERRACIALQVELRLQQF
Protein: Cystinosis nephropathic isoform 2 (A0A0S2Z3K3)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGYDQLN
Protein: Protein OPY2 (Overproduction-induced pheromone-resistant protein 2) (Q06810)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the high-osmolarity glycerol (HOG) pathway involved in mating response and osmotolerance. May act as a membrane anchor for the STE50/STE11 complex.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16543225}; Single-pass membrane protein {ECO:0000269|PubMed:16543225}. Vacuole membrane {ECO:0000269|PubMed:16543225}; Single-pass membrane protein {ECO:0000269|PubMed:16543225}.
Interaction partners:
- Protein STE50
- High osmolarity signaling protein SHO1
- Signaling mucin HKR1
- Signaling mucin MSB2
- Mitogen-activated protein kinase HOG1
- Osmolarity two-component system protein SSK1
- Cell division control protein 42
- Serine/threonine-protein kinase STE11
- MAP kinase kinase kinase SSK2
- Osmosensing histidine protein kinase SLN1
Sequence:
MSSSSKASASSSLSSTATSSTSATRGSDGCVVCDSTASCPVCASGEYCVMTSLTCDKCPSTYCAKQSDSQLSSLSSSSSSSSSSNSNEKTSLIVGFTVGIVGGAMLIALVALYFINKRYWKPKRQKNKALKLEEASQSYGNEEEYFDDEDDDDEDDEDDGGMRKDESHTLFNTSLVPPTLNVPGNRSSASTTRTRASNILPIAYIPGVTSGLSTDKLQSKLRSSSKRQNAAGDIRSHITLGSSILDGLDDEDDEHNQVLNKDADDNLITAIRAKPKLVQIAEEESDKEIQDLDVIEEQTEADDLSHMAKSEASHGNNDEDDDEEGSFILDLEIPESIRESTQGSRTESPFEDKFEIHDER
Protein: Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34) (Q14147)
Organism: Homo sapiens (Human)
Function: Probable ATP-binding RNA helicase required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons. Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3. Interaction with the RUVBL1-RUVBL2 complex results in loss of nucleotide binding ability and ATP hydrolysis of the complex. Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits.
Interaction partners:
- Regulator of nonsense transcripts 1
- Nonsense-mediated mRNA decay factor SMG9
- Nonsense-mediated mRNA decay factor SMG8
- Regulator of nonsense transcripts 2
- Serine/threonine-protein kinase SMG1
- Regulator of nonsense transcripts 3A
- Pre-mRNA-processing factor 17
- Cell division cycle 5-like protein
- Eukaryotic initiation factor 4A-III
- Pre-mRNA-processing factor 19
Sequence:
MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV
Protein: Serine hydroxymethyltransferase (EC 2.1.2.1) (Q4QFK2)
Organism: Leishmania major
Interaction partners:
- Aminomethyltransferase
- Aminomethyltransferase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Glycine cleavage system P protein
- Glycine cleavage system H protein
- formate--tetrahydrofolate ligase
- Putative methylenetetrahydrofolate reductase
- Putative beta eliminating lyase
- Acetoin dehydrogenase e3 component-like protein
- Putative dihydrolipoamide dehydrogenase
Sequence:
MASLIPTLTEQDPELANMIELEMGRQFRGLEMIASENLTSKAVLECLGSALTNKYAEGEPGNRYYGGTVFVDMVENLAKKRALAAFGLDPGEWGVNVQPYSGSPANFAVYTALLEPHSRIMGLDLPSGGHLTHGFYTPKKKVSATSIYFESFPYHVKEDGLIDYDALESVALVFRPKMIITGASAYARDFDYERFRHVCDEVGSLLFMDMAHTAGLIAGGVLKSPFPYADVVTTTTHKSLRGPRAGMIFYRKKDRQGKPTDHESRINQAVFPGCQGGPHEHQIAAIATQMREVCSQEWKAYARQVQSNARALAAALSSKGHVFVSGGTDNHLLLWNVRVHGLTGSKVEKLLDAVSISVNKNTIPGDKSAMTPGGIRVGTLALTSRGMVEADMSTVAEFLDRAIVLAKQIQAAMNAVKLSDFVEALQTHAGAAALRKDVEAFATTFAMPSFDVERIKYKDGLPEEQ
Protein: Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] (P17246)
Organism: Rattus norvegicus (Rat)
Function: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Subcellular location: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-1]: Secreted {ECO:0000250|UniProtKB:P01137}.
Interaction partners:
- Decorin
- TGF-beta receptor type-2
- TGF-beta receptor type-1
- Latent-transforming growth factor beta-binding protein 1
- Receptor protein serine/threonine kinase
- Endoglin.
- Transforming growth factor beta receptor type 3
- Latent-transforming growth factor beta-binding protein 4
- Integrin alpha-V
- Mothers against decapentaplegic homolog 7
Sequence:
MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDIREAVPEPPLLSRAELRLQRFKSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Protein: Nucleolar pre-ribosomal-associated protein 2 (Unhealthy ribosome biogenesis protein 2) (P47108)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15226434, ECO:0000269|PubMed:17145778}.
Interaction partners:
- ATP-dependent RNA helicase DBP6
- Nucleolar pre-ribosomal-associated protein 1
- Ribosome assembly protein 3
- 60S ribosome subunit biogenesis protein NOP8
- ATP-dependent RNA helicase DBP9
- ATP-dependent RNA helicase DBP7
- rRNA biogenesis protein RRP5
- U3 small nucleolar RNA-associated protein 10
- Nucleolar complex protein 2
- Ribosome biogenesis protein MAK21
Sequence:
MGDLTEELSIPDNAQDLSKLLRSTSTKPHQIAEIVSKFDKLETYFPKKEIFVLDLLIDRLNNGNLDDFKTSEHTWIIFTRLLDAINDPISIKKLLKKLKTVPVMIRTFFLWPKDKLLTRSVSFIKAFFAINDYLIVNFSVEESFQLLEHAINGLSSCPTTDFALSYLQDACNLTHVDNITTTDNKIATCYCKHMLLPSLRYFAQTKNSASSNQSFIRLSHFMGKFLLQPRIDYMKLNKKFVQENASEITDDMAYYYFATFVTFLSKDNFAQLEVIFTILGAKKPSLECRFLNLLSESKKTVSQEFLEALLLEMLASTDESGVLSLIPIILKLDIEVAIKHIFRLLELIQLENLNDPLFSSHIWDLIIQSHANARELSDFFAKINEYCSRKGPDSYFLINHPAYVKSITKQLFTLSSLQWKNLLQALLDQVNHDSTNRVPLYLIRICLEGLSEGASRATLDEVKPILSQVFTLESFNNSLQWDLKYHIMEVYDDIVPAEELEKIDYVLSSNIFDTTSADVEELFFYCFKLREYISFDLSDAKKKFMRHFEILDEERKSNLSYSVVSKFATLVNNNFTREQISSLIDSLLLNSTNLSSLLKNDDIFEETNITYALINKLASSYHQTFALEALIQIPIQCINKNVRVALINNLTCESFCLDSATRECLLHLLSSPTFKSNIETNFYELCEKTIMSPEMAISETGDEKKEIEDKISIFEKVWTNHLSQAKEPVSEKFLESGYDIVKQSMSLSNGDSKLIIAGFTIAKFLKPDNKHRDIQGMAISYAVKILENYSENFESETIPLFRISMSTLYKIITTGQGDISKHKSRILDIFSKIMLRYHSKKVYHAPEEQEMFLVHSLLTENKLEYIFAEYLNIEHTDKCDSALGFCLEESLKQGPDAFNRLLWNSAKSFSTISQPCAEKFVRVFIIMSKRIARDNNLGHHLFVIALLEAYTYCDIEKFGYKSYLLLFNAIKEFLVSKPWLFSQYCIEMLLPFCLKTLAFIVNHESTDEINEGFINIIEVIDHMLLVHRFKFSNRHHLFNSVLCQILEIIAIHDGTLCANSADAVARLITNYCEPYNVSNAQNGQKNNLSSKISLIKQSIRKNVLVVLTKYIQLSITTQFSLNIKKSLQPGIHAIFDILSQNELNQLNAFLDTPGKQYFKALYLQYKKVGKWRED
Protein: Kinesin-like protein (Q57X99)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEHIGAFLRVRPLLPREEAQGEEVCIVVQSGGTKVNATSRGTRGAQDQIHTFDMDCCLGPDVSQEEVFRALDLHAMCDAAFEGKAATIMCFGQTGSGKTYTMSGPTEGEDGRTAENGIQFEAVRYVSEFREKAQSAGEVEGRTIKLRASYLELFNERINDLLNGTEGLKCRWSKGAGCFFVEDLMIVECLDINDFMLVLREGQARRKRAAHLLNEDSSRSHLIFTIYAEVIDGEKPARRGKLTFVDLAGSERLRDTGGVGEDTKSINRSLFALGNVIERLSKGRSAGQRADHIPYRSSVLTQLLMNSLDGGCRTVLLACVTPSSRFVEESLRTIYFAQRAQKIQFKAVERVDTAQKEVYDLKTEIRRLREENLLLRRALHLPETGAIDPAALYAGRPDPHTPAGEVEKSRPIAAPKHASRRSPGPSSSTELFREGRPLEILMSPGDGVRRCQSSDAEPKSSALDILMGLPNSTDLVGQRQIPPREKLPLLQRAPVPKTLGFHIIPKKNRLFGPQAS
Protein: Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (Interleukin-17 receptor-like protein) (Sef homolog) (mSef) (Q8JZL1)
Organism: Mus musculus (Mouse)
Function: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. {ECO:0000250}.
Interaction partners:
- Interleukin-17 receptor C
- Interleukin-17 receptor B
- Interleukin-17 receptor A
- Interleukin-17 receptor E
- Interleukin-17F
- Interleukin-17B
- Interleukin-17A
- Interleukin-17C
- Interleukin-25
- Interleukin 17D
Sequence:
MAPWLQLCSFFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLHNITFRYDNCTTYLNPGGKHAIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFRRTGMESQPFLNMKFETDYFVKIVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMHVSFDHAPQNFGFRGFHVLYKLKHEGPFRRRTCRQDQNTETTSCLLQNVSPGDYIIELVDDSNTTRKAAQYVVKSVQSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESPESSTYAAALPRDRLRPQPKVFLCYSNKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWAIQKIHESQFIIVVCSKGMKYFVDKKNFRHKGGSRGEAQGEFFLVAVAAIAEKLRQAKQSSSAALRKFIAVYFDYSCEGDVPCSLDLSTKYKLMDHLPELCAHLHSGEQEVLGQHPGHSSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFIPFQHPPVRYQEPVLEKFDSGLVLNDVISKPGPESDFCRKVEACVLGAAGPADSYSYLESQHVGLDQDTEAQPSCDSAPALQPLLHAVKAGSPSEMPRDSGIYDSSVPSSELSLPLMEGLSPDQIETSSLTESVSSSSGLGEEDPPTLPSKLLASGVSREHGCHSHTDELQALAPL
Protein: CG10200 (Hase und igel, isoform A) (Hase und igel, isoform B) (LP02570p) (Q7JVV8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
- HL02234p
Sequence:
MKYAVIAIALFAITTASASSAGQFLPRAFFTLDSEGHQSNVHPVNAHLLRRLRRQSSSSSSSSSSSSSSGGNVFTYASHSVQNADGSGHSGSSYTQQAAAPVLGGVSFDERFGESSLTGGDNYYPTYNGYTSAASISSNSGVGSTGSYQHISGVGPIPATQIQQTVAVVDASGNQKVTNIQGATDSNGVLNIKKTESTYSSK
Protein: Copper-transporting ATPase (EC 3.6.3.4) (Q8I3A0)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Copper transport protein
- NADH-cytochrome b5 reductase, putative
- Glutaredoxin-1
Sequence:
MAKLSLTINNVDDDLKRKIKKAKFEGVEDLKHKNKKLTISYNPKVVDSYGVIERIKHLDINGEILKDDNDISSKNGNSFTFSMYKEGVEENVVKKANIFDDNENMQNTNNYIDNNSNNCNNLYGINNRDNYDKLDCNGNNADNNFDQIYDMNNMVNNYTYPNGEDLYEQLDNAYDDKNYKDNYKNYETNHQKCEQNYKNYEAIHQKCEQNYKNYEANHQKCEQNYKNYESNHQNHEQNYKSYGDNYQNCNVSEKNENINSNYNSTNNKGDLYDINYYPNQVEKVEESEGVDENRKSSKFSVLNLFNNIKKSKDKKKMKKEIKKDYLNEDYNNLDKRILLSNDMYKNVENKNYNNSNDNYNSNNNYYYDYNEEKLKKKNFNFRDYESYRDKQNIYICELKIYNMTCDNCGKKIINFLKDKKLILEGNSFATDNKIKLKIDISSDIIHCNNNVKMFVNTIMNEIKESGFNNDLLDLYKDDKNRCNLSEITLYIYRDDIKKSYKLLKDIKGISNVEYDLKKEYIYFLYDPELVGIRYILEILKKKKNVDAYYDEDKEKYFRSSQNNETNNTWKLIELSICIIISIIIIVLNKYQMNMGSMNGFYSYTKKLFDNSNKIDTDNIKHPSIYHNIGNGTPVDQSTLDIYFENVTKGKTLNEYVHKQSRRDEKGTFFINSNFKFIKKNKDSPINRKWVDDDIKKGQILNGKKNKSIEYNNTINMLNDQIDAGHYNNQEGHKDYPLDNENNVSKYIECTNSENRRKNYLLNEKDDDDNNKEKNINNNDNNNDEKNDNFNNDYNKDDYYDDEHYDIIPIGDFRKSDISEKHPDNKKGDNTKNGYSRFRKHINTNLKNKNNKNESDGEEEKGNIDGIYILKQKNHKKDMIKGEEENKDNFSKKEEKSDNENSNEEIDKNYNYLKRKEKDHNSSNDEDNINDSVLKENVKEEEIHESSSNEQSDSYLKKIEKKDNKNISVDNNENDNFLKKKEMKDVNNENEENRESSSLLKENKKKDNKNISVENNENDNFLKKNEMEDQNNKHVGSNVGDIVLKKNKKKDNKNTNDENNENDNFLKKKEKLYNNSSNEQNEENENFLKKKENTDNKNTNIQDKQNAIFLKNKKKKDDKNSKEENDESDNFLKKKVRTEDKNTNGQDKQDDIFLKNKQNDNVKSSHDQDNQNDDTFLKKKKIKDKNDNSNDEGNVSSLMLSKKEDENKSKNKKCDTNNSKDNIGEDNLGVSKEQDGKDSQDVKGGKHGQDVKDDKDEQDVKGGKHGQDVKDDKDEQDVKDGKHGQDVKGGKHGQDVKDDKDEQDVKDGKHGQDVKDDNDEQDVKDDKDEQDVKDDKDEQDVKDDNDEQDVKDDKDEQDVKDDKDEQNVKDDKEDKDIKGGKHGQDVKNDKHGQDVKNVKHGDVVKDGENENDSYDETEEDNFLMKKKEKKDENSTKDEKENIVMRKNKNSEISNEENNATYENENIFMNKNKSYNNSYKNEGNDDSLFSFNNLFYKLANYSIYLDMDTKIVKGLSLRLFFIFVLSSFVYIYYGFSFVLNGYKNLKNNMINMNVLISISSSFSYFYSLLLLLFCLIFSIDLNGIPLYFDSSALLICIMKFGCEIENFLVSFSKKKMEDLYESTAKNVYILEKKNRYYQDEEGNFNSNIPIKSMSNISKAFSKDNNSNSIIANSQINSNDILQSVGKENIKVDTLKNNLSFSTSSFFLSNQFLYDDDEINKILSQDMDININDYNINSYPVQFIQKNDILIFYEGSTLLIDGIKINKGISCVDESMISGEKNAIKKYKGDKVYAGSKCVEGVVIIYVKDISKGNYIEYVKQTLDEINCKKTNLQLYADKIASIFIPFILILCIVVFFIWFILTFFDIVNIKKENYFKLNRFLSCVFFSVHFSLSILCVACPCAVGLASPLSIAISTYICSSIGIIIKNINIFEIFLECKHFIFDKTGTLTVGKPVVNKIYISNNIDLFIDQLLKNKSGNHLSVSFNDNKNAKMPALVRAKSDEKKVKKMNNNMKDNVNKLYSTAYSINDQPSNGYNGYMNNFDEQGLEGNENMMKNNTLNFVENFSCCNKNVSFYSFTTEKEYFKIEIKKTSRNRDKVKKKKKYTKNETRNNYDESSLSGDKNYQNYQNYQNDQNDQIVSNSCMGENKSILNSIVSFITDKNKKNKYNKILDNSLKEHFINNSDNYFSSNDDSYYSETTSNENEHNKYDNIPVSNNIMDQHDHLQNMSSPLEEENSYMEKSSDWLYLFLSLSLNIEKYSNHLFATSINTYINNNFSINEVFDVNNLKNEKNQGISCIINDLTITIGTLFFCYTKYKNIYCNKVPIIEEKLTVKSMERHIYSCDCNVHKTYQYLYSYSNSKKNESNNIIFMCIEGIVVGFFTLVDNIKPEVFELINFLKREKKKVYVCTGDNYMNALYISKILGIKKENVSSNTLPLEKVQFVKKVQSMNDGKVCMIGDGINDCFALKTADLGLSLCTRTNVVMDSADACIVDNNINVIIKLFEISRKTLLVIKFNFLFSFFINIFFILLASGAFYSLNYVFSPFLFTFLMFCSSIIVILSSLSLKLLLKNI
Protein: HCG15971, isoform CRA_a (PS1TP5-binding protein 1) (Q1KLZ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Protein: Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 39 kDa subunit homolog) (eIF-3 39 kDa subunit homolog) (eIF3 p39) (Suppressor of uncontrolled mitosis 1) (P79083)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit H
- Probable eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit A
- Probable eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit G
Sequence:
MRPIILQGHERPLTQIKYNHDGDLLFSCAKDKVINVWFSHNGERLGTYEGHTGAIWTCDINKSSTLMVSGAADNTMRLWDVKTGKQLYKWEFPTAVKRVEFNEDDTRILAVTEERMGYAGTVTVFRVPISESDAAAETPLYVITTRESKATVAGWSYLSKFLFTGHEDGSVSRYDAITGEFVESKQVHNSGSTITDLQFYPDRTYFITSCKDTTAKAIDVDSFEVIKTYLTDTPLNTSSFTPVQDFVILGGGQEARDVTTTAARQGKFEARFYHAILEEELGRVKGHFGPINTIAVHPKGTGYASGGEDGYVRVHFFDKNYFDFKYTL
Protein: Seripauperin-1 (P0CE88)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGISPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTIAN