wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (Ubiquitin-activating enzyme E1 homolog) (Q9DBK7)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P41226}. Nucleus {ECO:0000250|UniProtKB:P41226}.
Interaction partners:
- Ubiquitin-like protein ISG15
- Ubiquitin/ISG15-conjugating enzyme E2 L6
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-C
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-like modifier-activating enzyme 1 Y
- Ubl carboxyl-terminal hydrolase 18
- E3 ubiquitin/ISG15 ligase TRIM25
Sequence:
MDEELYSRQLYVLGLPAMQRIQEAKVLLCGLQGLGAEVAKNLVLTGVGSLTLHDPHPTCWADLAAQCFLSEESLGRNRAEASQAQLAQLNEAVQISVHSGDITEDLLQGFQVVVLTDSKLEDQLKVGPLCHKHGVRFLMAETRGLVGRLFCDFGEDFTVLDPTEVEPMTAAIQDISQGFPGIVTLRGDTKRHSFHDGDLVIFSDIEGMVELNSCSPQSVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVRHKPLDIALLQPHVVAQNTQEVQRAHCLHQAFHVLHKFQQLHGRLPKPWDPDDAETVVELAQDLEPLKGTEEESLDEALLRTIALSSAGTLSPMAAIMGGVAAQEVLKAISRKFMPLDQWLYFDALECLPEDETLLPSPEDCQPRNCRYDGQIAVFGTDLQEKLSDQHYLLVGAGAIGCEMLKVFALVGLGVRANGGVTVADMDYIERSNLSRQFLFRPKDVRRPKAEVAAAAAHRLNPDLRATPYTCPLDPTTEDIYDDSFFSRVNGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTWGSASVFVPYVTEAYRGPASDAASEDAPYPVCTLRHIPSSMEHSVQWAQDQFEGLFRLSTETINCYQQTCTSLSATDRTETLALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFHDKVLEGGTQFSSGSNKCPHPLQFDPNHDMHFLYVLAAANLYARMHGLPGSQSQPALRELLTRLLESDSRPQNLFSAEHGQEQLKELQETLDDWRKGPPLKPVLFVKDDDSNFHVDFVVAATDLRCQNYGILPVNHARIKQIVGRIIPAIATSTAVVAGLLGLELYKVVSGLRSHGTFRHSYLHLAENHFIRSAPSAPAVQSFRDLKWTCWDRLKVPAVQPERTLKSLLAHLQEEHGLKVEMLLHHQALLYSSGWSSEKQAQHLCLRVTELVQHVTGWKPKPGLKVLVFELSCEGEEEEMAFPPLHYEL
Protein: Abequosyltransferase RfbV (EC 2.4.1.60) (O antigen biosynthesis abequosyltransferase RfbV) (P26401)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Catalyzes the transfer of CDP-abequose on D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid to yield D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid.
Interaction partners:
- Putative O-antigen transporter
- CDP-abequose synthase
- Glucose-1-phosphate cytidylyltransferase
- CDP-glucose 4,6-dehydratase
- Undecaprenyl-phosphate galactose phosphotransferase
- O-antigen chain mannosyltransferase RfbU
- Gifsy-2 prophage protein
- Lipopolysaccharide biosynthesis protein RfbH
- Acetylornithine deacetylase
- SsrB-regulated factor
Sequence:
MLISFCIPTYNRKEYLEELLNSINNQEKFNLDIEICISDNASTDGTEEMIDVWRNNYNFPIIYRRNSVNLGPDRNFLASVSLANGDYCWIFGSDDALAKDSLAILQTYLDSQADIYLCDRKETGCDLVEIRNPHRSWLRTDDELYVFNNNLDREIYLSRCLSIGGVFSYLSSLIVKKERWDAIDFDASYIGTSYPHVFIMMSVFNTPGCLLHYISKPLVICRGDNDSFEKKGKARRILIDFIAYLKLANDFYSKNISLKRAFENVLLKERPWLYTTLAMACYGNSDEKRDLSEFYAKLGCNKNMINTVLRFGKLAYAVKNITVLKNFTKRIIK
Protein: CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) (Q8BIF0)
Organism: Mus musculus (Mouse)
Function: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000269|PubMed:17344467}. Secreted {ECO:0000250|UniProtKB:Q8TCZ2}. Note=Concentrated at cell-cell contacts in cultured endothelial cells.
Interaction partners:
- CD99 antigen
Sequence:
MVARLTAFLVCLVFSLATLVQRGYGDTDGFNLEDALKETSSVKQRWDHFSTTTRRPVTTRAPANPAERWDHVATTTTRRPGTTRAPSNPMELDGFDLEDALDDRNDLDGPKKPSAGEAGGWSDKDLEDIVEGGGYKPDKNKGGGGYGSNDDPGSGISTETGTIAGVASALAMALIGAVSSYISYQQKKFCFSIQQGLNADYVKGENLEAVVCEEPQVTYSKQETQSAEPPPPEPPRI
Protein: Slk19p (Q5ADT0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Cta3p
Sequence:
MSETKEAPKPTKQESQGILKKLTSGDTWVSPFRSQASEEDPKKKINLYKQFKESNKIEHIKVPVKFSYHPTLEAEAKKKKAAEAEAKKAKETKATVTSTEAKDAKEETETKAEKVEEKLETDAKEPLIEDETKEEAKVDTEAKEPLIEDEDKQEPANEAEEKEAELEDKAEEKLVTDQPKDEEIEVAEPKEVSAASEVEEQKLEKDAAEPEIQDGEALKGDDNIEKQIKENPIELVDQPSQFKYEPVELPNKETLDKLQDKPVLLKHYQELNAIGVGSIANRIEDPNKVIELGSGLRMTQQQLLDIAAKRVAPVITNINDEVSKTRQEDEIKRQQGLDNKVKKHESKLQSDFEKYLGKIGKKKDKFNKEIEEKLANFETMIKKSNNTAIEFEKTTKGEIETANKEYEEREAKAVEQHATDKETIEKNHEELLATKKQELEDAKTGQETATQEIEELKDKKTELDDKNSELADKIEQLTAQLNTELAKLDDLKANHKEHQDSIDANLTKKKELDDNLTIIRKDLSDKKEKHKGLSAEVGVLAGSAAAYAARLTSLHSDKEDRAKRLAEAKDKHASWLKEKRELAEQTARDHERKRLEATHEYETQKHLEELERQKQKEELERKEKEEAEERERQAKIEAEERERKEKEEAEEKARLEKEQAEKEAKEKELKEQQEKEEAQKKKNDVEYQVSQAILSRETDQKKFEEERAESERIYNERKAKEKEETDRLLKEIEDLKAEKEKAAELEREEAEKVAQAKLAQIEKLKQEHEAKTKLFNDKLEFENLQKQRLEEEVANLKKIRELREEKARLASEQYKDPELERVKKLIQERELEVDKLTKVIEFEKPEQTSSEGGHFLGISNDSKSGAIPVIKSKDVVVGNNENSHSKSVNTGNEAKTENESDDKKKDHHYGGAALGIAGGILAAAGAGALAAGSAGKNAVSGIASGVSNAVPSGNKDVQLPSNGSGTQGNTTTSAPGQSQSSSPLATTTEPSGSAASIPTSSNTSTISSKKNAASVTPTPVEAQRTNSLSDKFKGWGRKLSKKDKSKDVNSAAGETTAETGVIAKDDDKPVGGITALDAEKNTVVARDAKPIGGVTALDAEKNTVVARDTKPIGGINANDIEEKPSVGIFVSKNVSSNKTSTDADDESFEIQSVYEVVSDSEYEANKHNPNYFEVSPEEFEKHKNLENKVVLIEKISE
Protein: Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) (Q640R3)
Organism: Mus musculus (Mouse)
Function: Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity).
Subcellular location: Cytoplasm. Cell membrane {ECO:0000269|PubMed:22405205}; Single-pass type I membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14CZ8}. Note=Colocalizes with CDH1 (By similarity). Colocalizes with CLCN2 at astrocyte end-foot in contact with brain capillaries and other glial cells (PubMed:22405205). {ECO:0000250|UniProtKB:Q14CZ8, ECO:0000269|PubMed:22405205}.
Interaction partners:
- ATP-sensitive inward rectifier potassium channel 10
- Volume-regulated anion channel subunit LRRC8A
Sequence:
MKRERGALSRASRALRLSPFVYLLLIQPVPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDKPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCVVENPISQVRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKKSRKKRKLEKQNSLEYMDQNDDRLKSEADTLPRSGEQERKNPMALYILKDKDSSEPDENPATEPRSTTEPGPPGYSVSPPVPGRSPGLPIRSARRYPRSPARSPATGRTHTSPPRAPSSPGRSRSSSRSLRTAGVQRIREQDESGQVEISA
Protein: G protein-coupled receptor kinase (EC 2.7.11.-) (B5LZ08)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Presynapse {ECO:0000256|ARBA:ARBA00034106}.
Interaction partners:
Sequence:
MADLEAVLADVSYLMAMEKSKSTPAARASKKIILPEPSIRSVMQKYLEERDELAFDKIFNQKIGFLLFKDFCMNEIDEAVPQLKFYEEIKEYEKLDSEEERLTRSRQIYDVYIMKELLSCSHPFSKKAVDHVQTHLAKKQVPPNLFQPYIVEICDSLRGNIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKDMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFTPELKSLLEGLLQRDVAKRLGCLGRGASEVKEHVFFKGIDWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPLVISERWQQEVAETVYEAVNSDTDKNEARKRAKNKQQGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRVEWRGEGESRQNLLTMEHIVTVEETQIKDKKCILLRVKGGKQFVLQCESDPEFVQWKKELTEAFTEAQKLLRRAPKVIGKGRTNVVELSKPPLTHRNSNGL
Protein: Beta-defensin 121 (Beta-defensin 21) (DEFB-21) (Defensin, beta 121) (Q5J5C9)
Organism: Homo sapiens (Human)
Function: Has antibacterial activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Beta-defensin 129
- Beta-defensin 113
- Beta-defensin 115
- Beta-defensin 108B
- Beta-defensin 135
- Beta-defensin 126
- Beta-defensin 110
- Beta-defensin 131A
- Beta-defensin 116
- Beta-defensin 106
Sequence:
MKLLLLLLTVTLLLAQVTPVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVDPKYVPVKPKLTDTNTSLESTSAV
Protein: Two-component response regulator-like APRR2 (Pseudo-response regulator 2) (TOC2 protein) (Q6LA43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Calmodulin-like protein 9
- BEL1-like homeodomain protein 11
- Translocon outer membrane complex 75-I
- Pinoresinol reductase 2
- F-box protein At1g80960
- Phytoene synthase 1, chloroplastic
- Protein LOL1
- Light-mediated development protein DET1
Sequence:
MVITANDLSKWENFPKGLKVLLLLNGCDSDGDGSSAAETRSELESMDYIVTTFTDETEALSAVVKNPESFHIAIVEVNMSAESESFKFLEAAKDVLPTIMISTDHCITTTMKCIALGAVEFLQKPLSPEKLKNIWQHVVHKAFNDGGSNVSISLKPVKESVVSMLHLETDMTIEEKDPAPSTPQLKQDSRLLDGDCQENINFSMENVNSSTEKDNMEDHQDIGESKSVDTTNRKLDDDKVVVKEERGDSEKEEEGETGDLISEKTDSVDIHKKEDETKPINKSSGIKNVSGNKTSRKKVDWTPELHKKFVQAVEQLGVDQAIPSRILELMKVGTLTRHNVASHLQKFRQHRKNILPKDDHNHRWIQSRENHRPNQRNYNVFQQQHRPVMAYPVWGLPGVYPPGAIPPLWPPPLQSIGQPPPWHWKPPYPTVSGNAWGCPVGPPVTGSYITPSNTTAGGFQYPNGAETGFKIMPASQPDEEMLDQVVKEAISKPWLPLPLGLKPPSAESVLAELTRQGISAVPSSSCLINGSHRLR
Protein: MutS protein homolog 5 (Q19272)
Organism: Caenorhabditis elegans
Function: Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks. Together with him-14 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells.
Subcellular location: Chromosome {ECO:0000269|PubMed:29521627, ECO:0000269|PubMed:30379819}. Note=From mid-pachytene, co-localizes with cosa-1 and rmh-1 at crossover sites of early recombination intermediates (PubMed:29521627, PubMed:30379819). Co-localizes with brc-1 at crossover sites in mid-late pachytene nuclei (PubMed:30383754). {ECO:0000269|PubMed:29521627, ECO:0000269|PubMed:30379819, ECO:0000269|PubMed:30383754}.
Interaction partners:
- MutS protein homolog him-14
- DNA mismatch repair protein S5 domain-containing protein
- Meiotic recombination protein spo-11
- DNA repair protein RAD51 homolog
- Mismatch repair endonuclease PMS2
- Cyclin N-terminal domain-containing protein
- Zip homologous protein 3
- Crossover junction endonuclease MUS81
- RecQ-mediated genome instability protein 1 homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 1
Sequence:
MSTRWRYYNSKRGNGFRGRGRGRGRGTSLTAVALPRDDNFHKGAQDGAYFKDMPMDPEQFRDETVLSLSFAQGMLGAAYYEQSSQLLKIMNDISEDLEFRFLKRLIDDVKPTLIIANRSQDLEFIKFLTTRYDPQEKIYEDGTTEEGTSEDTVPTWDSSLAYSTDETTAEKEEKEEDEDDDDEGLPAKLNKLPNNFFRMSRAIERLKAMAGSHDSSMTEEDKYIIIKMRFDIEAVNMIRSFGALLLFLDETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKKTFGQGRSLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDLVSRQKCVHYFKQDWNAEVTAKLSSILGRVKALNSVFQKFQSGTAQLIHWECFVSTVNALVEILNIIRQTPISKEFPVESDLLREVSEIAVIAGSIINFAESKIQGRVTVMNGIDEELDEIRDTYENMPMVLTAIAKQEEARLGLPPYSNVACVYIPLVGFVLSVPRDYGVESQPDMTLLYSTHEDLRVRNATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKKRSIIKLLSIASRIDVLISFGLIAAQNGWNCPALVDEPVIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALKAGTLLKEIKAEVSNDNEKQLVEDMDVVLADEDGFMAAVESFVKRKKTSFCESSMRNVSEEIEKERSEASTPASKSRSTITARSNSVLSSRSMASVDQLSVLDALLPKKKKKKVTGSSMESSMSPDPFQEEDEGTEGEEDQISAPVSRPTLPSVQKYASEEEKQQSINSRHSFSTRTAIHIPTPIQMGEAGGVKRPRSTSTSSPGPSASKSVRTEVFKKTPNVKESQVLETPKQLSISSFLEPKFPSSEKDVISRVSERYLQSDPFKTPISDRRSQQSSRHSTPKNRSMNQSLIQSARDTPHETIRSSNEVNPEFFNIFNFPDDSILKSQDTYDPNVTPRSSSRRELRPDVSHSQNSQFGEVFSELGTQFSIFNSQQSFPGNSMGTTNPDCSIFDDFFANSQDGEKKIDSTKTSMPIVNSDNFIFKTPEPRSSEKQRSLLKNKGQASNSSISPSSLILGQLAFGDVDQTPRPRGDNPIEFQYDVVDDDDPIFEEKNCSAPVFEFLKSNDDEEDDEFLKSFLETEGSLHIDTSADETIDRSKRS
Protein: Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) (Vesicular monoamine transporter 2) (Q27963)
Organism: Bos taurus (Bovine)
Function: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q01827}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q01827}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q01827}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q01827}. Note=Sorted to large dense core granules in neuroendocrine cells, presumably at the level of the trans-Golgi network. In neurons it is predominantly detected in somatodendritic tubulovesicular membranes, a distinct population of secretory vesicles that undergo calcium-dependent exocytosis in axons and dendrites upon depolarization. Localized at synaptic vesicles in axons. {ECO:0000250|UniProtKB:Q01827}.
Interaction partners:
- Alpha-synuclein
- Vesicular glutamate transporter 1
- Vesicular glutamate transporter 2
- Vesicular inhibitory amino acid transporter
- Solute carrier family 17 member 8
- Vesicle-associated membrane protein 2
- Solute carrier family 18 member 3
- Solute carrier family 18 member A1
- Synaptotagmin-1
- Aromatic-L-amino-acid decarboxylase
Sequence:
MALSELALLRRLQESRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIEHEKDALEIQTAKPGLTASAPGSFQNIFSYYDNSTMVTGNSTDHLQGALVHEATTQHMATNSSSASSDCPSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFTGFCIMFISTVMFAFSRTYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLRDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSHKWQLGVAFLPASVSYLIGTNVFGILAHKMGRWLCALLGMIIVGMSILCIPLAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNSSQSHPIGEDEESESD
Protein: Uncharacterized protein C683.02c (Q9HFF2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized RNA-binding protein C25G10.01
- Nucleolar protein 12
Sequence:
MARITNMGKRKRFLEATPYESKVLEQPKNSSNTNEESSSQDNMKASFGSSKRYDERQKKKRSEYRRLRRINQRNRDKFCFACRQQGHIVQDCPEAKDNVSICFRCGSKEHSLNACSKKGPLKFAKCFICHENGHLSGQCEQNPKGLYPKGGCCKFCSSVHHLAKDCDQVNKDDVSFGHVVGVAGTTGADEDVYHEYAKTVAAPTKKRPVKPVKKLVTF
Protein: AT3g27050/MOJ10_14 (Plant/protein) (Q94JV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASSLQSSGMLTKEQMVYLFDRFDYLTSQSDVKKRISDAVDDKQEAVAVTTAIQEEIFLEMGIDPGFGIGCLGKLNSAYENDKELMIGFYKFLAKEEMACEEAELGQDGFEQKMKALQQLQEQQLEMLKYMRKFSLDDQSAILQKLQKQLENAGFEPEASLLSGEEMEEAGRRRVSPVFGSR
Protein: RING finger protein 208 (Q9H0X6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPSDPGPEAGSGWPGLLMSCLKGPHVILKMEAMKIVHPEKFPELPAAPCFPPAPRPTPTLAPKRAWPSDTEIIVNQACGGDMPALEGAPHTPPLPRRPRKGSSELGFPRVAPEDEVIVNQYVIRPGPSASAASSAAAGEPLECPTCGHSYNVTQRRPRVLSCLHSVCEQCLQILYESCPKYKFISCPTCRRETVLFTDYGLAALAVNTSILSRLPPEALTAPSGGQWGAEPEGSCYQTFRQYCGAACTCHVRNPLSACSIM
Protein: Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) (P12532)
Organism: Homo sapiens (Human)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Interaction partners:
- Guanidinoacetate N-methyltransferase
- Cation channel sperm-associated protein 2
- Stereocilin
- Ankyrin repeat and SOCS box protein 9
- Sodium- and chloride-dependent creatine transporter 1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
- Creatine kinase S-type, mitochondrial
- Nucleoside diphosphate kinase, mitochondrial
- Glycine amidinotransferase, mitochondrial
- Non-selective voltage-gated ion channel VDAC1
Sequence:
MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADLFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH
Protein: Spermatocyte protein spe-8 (EC 2.7.10.2) (Defective spermatogenesis protein spe-8) (O01798)
Organism: Caenorhabditis elegans
Function: Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25022984}; Peripheral membrane protein {ECO:0000269|PubMed:25022984}. Cytoplasm {ECO:0000269|PubMed:25022984}. Note=Localizes mainly in the cytoplasm of stage I spermatocytes and at the cell membrane of stage II spermatocytes and spermatids. {ECO:0000269|PubMed:25022984}.
Interaction partners:
- SPE-12
- CX domain-containing protein
- Trypsin-like protease try-5
- Spermatocyte protein spe-27
- Serine/threonine-protein kinase spe-6
- Spermiogenesis protein SPE-29
- Serine protease inhibitor swm-1
- Serine/threonine-protein phosphatase PP1-gamma
- Integral membrane protein
- Domain of unknown function DX domain-containing protein
Sequence:
MRSKSSEGDLQPEDTQSREDKETTATYSEDTKPETQKERNAALDNLAKTPIQLVVQPTPLTPAITPCEAPPPPPPPKPSSDNNNSKRLKVKDQLIEVPSDEVGRVENNIDNFPFYHGFMGRNECEAMLSNHGDFLIRMTEIGKRVAYVISIKWKYQNIHVLVKRTKTKKLYWTKKYAFKSICELIAYHKRNHKPIYEGMTLICGLARHGWQLNNEQVTLNKKLGEGQFGEVHKGSLKTSVFAAPVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAEDKILYLFHAACGIDYLHGKQVIHRDIAARNCLLNSKKILKISDFGLSVKGVAIKERKGGCLPVKYMAPETLKKGLYSTASDIYSYGALMYEVYTDGKTPFETCGLRGNELRKAIIGKRISLAVEVELPVFIANIFEQSRQYETEDRISSKQIIQIFKEEVGFHEIETSGILHKLVNSLPRIHNKERKPAAVAV
Protein: SH2 domain-containing adapter protein B (Q15464)
Organism: Homo sapiens (Human)
Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase Src
- Vascular endothelial growth factor receptor 2
- Dehydrogenase/reductase SDR family member 2, mitochondrial
- Adapter molecule crk
- Focal adhesion kinase 1
- Proto-oncogene vav
Sequence:
MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL
Protein: 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1) (Q8N4T8)
Organism: Homo sapiens (Human)
Function: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}.
Interaction partners:
- (3R)-3-hydroxyacyl-CoA dehydrogenase (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (KAR alpha subunit) (Estradiol 17-beta-dehydrogenase 8) (Protein Ke6) (Ke6) (Testosterone 17-beta-dehydrogenase 8)
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Hydroxyacyl-thioester dehydratase type 2, mitochondrial
- Fatty acid synthase
- Neuronal-specific septin-3
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Sequence:
MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL
Protein: Albumin (H7C013)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
GFEWGGQRRASHNSTFSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQA
Protein: Insulin receptor substrate-3 (O54718)
Organism: Mus musculus (Mouse)
Interaction partners:
- Growth factor receptor-bound protein 2
- Insulin-2
- Insulin receptor
- Insulin-1
- Insulin-like growth factor 1 receptor
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Tyrosine-protein kinase JAK2
- Serine/threonine-protein kinase mTOR
- Suppressor of cytokine signaling 3
- Suppressor of cytokine signaling 1
Sequence:
MKPAGTGPTVSSGGECTDVSLGSPFPWPCLPDVRLCGHLRKQKSQRRRFFVLRADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLIVIYTSDSSLGVAAASEAEQQAWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQDVWPVTLRSKGLGRAQGLSSGSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSLLSVRRCGHADSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSNAAGKAEPPPQGNPPKSVPAAPTPTPYEIPASAAQARSPSERAKQDYFKPLERMGSTHSYKGLDLGGNYITMGVRNDYVHMGGGEAGDYMWMAPPGLPPTPARADPNKQLEDCESTEYVPMNRFLPGPFYYELKARESELGHPGAHCSLRDRWRPTVAQPRSSQGSELSGDYMSIPDYVGTDSARLGSLDSCLNYVDLDLVPPLEVPGAAPGKSPHSYASIKF
Protein: Uncharacterized protein (Q383K1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGPSEYDELENIVERCSARGPNTCGWKITMTEDIHDEPDRLNGYPFADHNGIGVRLSYTKGSITVRANVSSNPKTTWCDLLPTLKWRRDAHGAQHTFFLHMAATPRFTYTLRHPEFFITSDTNLVDGFVSRCTATTRISPKNQVGVSFTYDPSRSGLKDYTFLFAREACAAVLGGDVVAKYNATRGIGLHLRVPTNAYTSAVVLAEKQRFIVGAEARSSCGAQMLMNINLVDQRAEVALSRFFGPVWQVALNYSAVLNKPTTGYISTVSPRFGIVFTGR
Protein: Uncharacterized protein C3orf62 homolog (Q9D9C7)
Organism: Mus musculus (Mouse)
Function: Essential for normal spermatogenesis and male fertility.
Interaction partners:
Sequence:
MSEKLRRCRKELTAAIDRAFEGVRHSQECTAQQRLDAPSLTSQPVHRLLCRNPLAACPSAAPYSGASCAPESENPAFGTHHIPVNSKLQQPLYPKRKPLTSKENVLMQSSILARDRQFWRAAGDGEDWRKDSLRKDMERDLKADPNVLLSSSSQEVTKDLLDMIDHTSIRTIEELAGKLEFENELNRVCGHCQDSPFKEEAWALLVDESPQKALDADPGSLKQALDDQNIVETVLDLEEDYNLMTSFKYQIE