wanglab/gogpt-training-data huggingface dataset:
Protein: Carbonyl reductase [NADPH] 2 (EC 1.1.1.184) (Adipocyte protein P27) (AP27) (Lung carbonyl reductase) (LCR) (NADPH-dependent carbonyl reductase 2) (P08074)
Organism: Mus musculus (Mouse)
Function: May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:8040004}.
Interaction partners:
- Carbonyl reductase 1])
- Carbonyl reductase 3
- Cytochrome P450 2E1
- Prostaglandin E synthase 2
- Prostaglandin E synthase
- Prostamide/prostaglandin F synthase
- Cytochrome P450 1A1
- Prostaglandin E synthase 3
Sequence:
MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSDRSASTSGGGILVDAGYLAS
Protein: Leukotriene B4 receptor 2 (A0A3Q5ACI7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
Protein: Putative uncharacterized protein encoded by LINC00242 (Q5T6M2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMPRHLLPHSGITSLRRVPRRRLPSRRREDFRRCLFLSFVSTDKDGDPTGQASPAVPVPHFTTWGSLIPIDSQRNKERTRFTWMDGPPHGGLGTRFSGRGSASLTAPPGRCFTRERHPVPRQRKCRRQHSTGRKPHCGTRSAAPRNPKSIHKRSFSAKSLKNKTRNESPPVSALVSRTKTQPGQLHFCCQPSSSQAPASRRAKGR
Protein: p44-70 outer membrane protein (Q2GK57)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MVKGNGSIFMTSVLGVRCMSARSCRKLFLGSIMLSFAVLMTSQEVQAMHSGQNISDMGESNYFYVGLNYSPVFSKIRDFTISESSGETKAVYPYLRDGKSVKLETNRFDWSVPDPQIRFKNSVLLAMEGSIGYTMGALRFEVEVGYERFKIKSRYGKGIRGEESDTIYLLAKELAYDVVANKTDALAAALAKVKGQDIVHFANTLKITHPWINEQICNRGNDLLDNGGLKDSKKGSCNSKDKKGGKLEQSFTAALGDQGAQKWPKINNGGKKLTGKSNGKPYALDASATVAGDISVLDRESKVMVAGLLARTIEGSEIVEIKAISSTSVMLNACYDIFSEGFGIMPYTCIGLGSNFVSIVDGKVTPKLSYKLKAGLSYKFSPEVSAFAGGFYQRVVGDGEYVDLPVKRLSYDLSPQGRTKETAVAKFSMSYVGGEFGIRFAF
Protein: Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) (Q9BRS2)
Organism: Homo sapiens (Human)
Function: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21081503}.
Interaction partners:
- Protein LTV1 homolog
- RNA-binding protein NOB1
- Protein arginine N-methyltransferase 5
- Methylosome protein WDR77
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS11
- Serine/threonine-protein kinase RIO2
- RNA-binding protein PNO1
- Probable RNA-binding protein EIF1AD
- Small ribosomal subunit protein eS7
Sequence:
MDYRRLLMSRVVPGQFDDADSSDSENRDLKTVKEKDDILFEDLQDNVNENGEGEIEDEEEEGYDDDDDDWDWDEGVGKLAKGYVWNGGSNPQANRQTSDSSSAKMSTPADKVLRKFENKINLDKLNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYIPRTLNEVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDLSGVQKVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHARPKKHTTDPDIDKKERKKMVKEAQREKRKNKIPKHVKKRKEKTAKTKKGK
Protein: Chemosensory protein A 29a (Putative pheromone response factor) (Q8T0X8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Chemosensory protein B 42a
Sequence:
MWHCELKVFLILWTVSQVYIPCWGKKFISRFESINGIEGEKETLFTCSVRLVGRERMLNGSIMHQVDLDDSFDVWMDILHFKNGEWAQGNIKVRTKPCDWFTNYFGKYFLPLVKDSNLPPIQEMCVFPKGEYYLRITKIEPQNWPPILYRGLNQFNINYVRDGKSTGGIQFVIDLEDSTL
Protein: Gem-associated protein 7 homolog (G2TRR1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein new12
- Uncharacterized protein C16H5.15
- SMN complex subunit yip11/gem2
- SMN complex subunit smn1
Sequence:
MAENNKKSTAYIQRMRTLKFYQKMASARIPITVYLHDQREVKAEFGAIDSSESKLAVSNLQTDWGVINRAVIRTGDVVGIEYNLVQEEGEL
Protein: JAZF zinc finger 1b (Juxtaposed with another zinc finger protein 1b) (Zinc finger protein Seson) (Q49TU3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- 3-hydroxyisobutyrate dehydrogenase
- WD repeat-containing protein 82
- Symplekin
- Fibronectin type 3 and ankyrin repeat domains protein 1
Sequence:
MTGIAAASFFSNICQFGGCGLHFESLAELIVHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREHESLKKKVQPKLSLSLMGSLSRSSVATPPRHNSGNLTPPVTPPITPSSSFRSSTPTGSEYDEEEAEYEESDSDESWTTESAISSEYILSSMCMNGGDEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKSSQGLRHHTINFHPPVSAEIIRKLQQ
Protein: Sestrin-1 (EC 1.11.1.15) (Q6DG05)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- GATOR2 complex protein WDR24
- Nucleoporin SEH1
- GATOR2 complex protein MIOS
- GATOR2 complex protein WDR59 isoform X1
- DEP domain-containing 5, GATOR1 subcomplex subunit.
- NPR3-like, GATOR1 complex subunit.
- GATOR complex protein NPRL2
Sequence:
MRHALASNETMENSSLTMTDLFKICTQCERLSKKDVGVRIPRPVGNGPSRFIPEKEILQVSKLDERTQSIFEDAFAVLGRLDNISLVMGFHPQYLESFLRTQHYLLQMDGPLSLHCRHYIGIMAAARHQCTYLVNLHVNDFLQVGGDPKWLNGLEEAPRKLQALGELNKILAHRPWLLTKEHIERLLKAEEHSWSLAELIHAVVLLTHYHSLASFTFGCGITPDIHTDGGHTFRPPSLSGYCVCDIANGNGAQEDMFGNQQVSESSGEVEVLMERMKQLQECRDEEEASQEEMATRFEREKTECMLVVTSEDEECVPSRDVSRHFEDPSYGYKDFSRRGEHVPTLRVQDYSWEDHGFSLVNRLYSDFGQLLDEKFQIAFNLTYNTMATHQGVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTMVCSPEKITKRMYESFWRQFRHSEKVHVNLLLMEARMQAELLYALRAITRYMT
Protein: Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (O35800)
Organism: Rattus norvegicus (Rat)
Function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q16665}. Nucleus. Nucleus speckle {ECO:0000250|UniProtKB:Q61221}. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (By similarity). {ECO:0000250|UniProtKB:Q16665, ECO:0000250|UniProtKB:Q61221}.
Interaction partners:
- von Hippel-Lindau disease tumor suppressor
- Histone lysine acetyltransferase CREBBP
- Aryl hydrocarbon receptor nuclear translocator
- Aryl hydrocarbon receptor nuclear translocator 2
- Egl nine homolog 1
- Endothelial PAS domain-containing protein 1
- Hypoxia-inducible factor 1-alpha inhibitor
- Cullin 2
- Elongin-C
- Prolyl hydroxylase EGLN3
Sequence:
MEGAGGENEKKKMSSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKAPDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVRKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTSSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKDSQPQCIVCVNYVVSGIIQHDLIFSLQQTESVLKPVESSDMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVPLYNDVMFPSSNEKLNINLAMSPLPASETPKPLRSSADPALNQEVALKLESSPESLGLSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSAQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNSPSPPSVSTVTGFQQTQLQKPTITVTAATATTATTTDESKAVTKDNIEDIKILIASPPSTQVPQEMTTAKASAYSGTHSRTASPDRAGKRVIEKTDKAHPRSLNLSVTLNQRNTVPEEELNPRTIALQNAQRKRKMEHDGSLFQAAGIGTLLQQPGDRAPTMSLSWKRVKGYISSEQDGMEQKTIFLIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
Protein: Podocin (Nphs2 protein) (Podocin isoform X1) (A4FVJ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLPAEIEKRTETETSRHSSRSARIKREPSPSAKERKTKAAKSVKLQEPHKRKEKLVTTEEEEEAKDAQIISSSTVVNVDSVRERIKEEREELLALLETEGPGEGLKKKYLGVCELLLIVLVLSVVILFLPISVWFCVKIVREHERAVKFRLGHLLKKRPRGPGLMFYLPFLDVCHIVDIRLQILKIPPHMVVTKDLVCTEVTAVCYYRIENVSVCYSSFASIPDVMQALTQVSVREILAHHAFNDILLDRKRIAQEIQVTLDSGTCRWGIKVEKAEIEEINLPPELQHNFAVEAEARRQAQVKVIAAEGEKAACEALKASVESVSGSPLVMHLRLLQLLHSLRSEQPAVVLNIPPDVLTQSIDLASLTRPANQSMTTCHGSDDGTKDSPMM
Protein: Darlin (Armadillo-like protein A) (O76187)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Part of a signaling pathway that initiates the aggregation and leads to the formation of aggregation centers or streams. Not essential for cytokinesis, pinocytosis or phagocytosis. Not essential for development, except in starvation-induced aggregation.
Interaction partners:
- Rho-related protein racC
Sequence:
MEEIQKLINELGGSQYKDKDTEHYSEEAVELLIKKIDNKSKGKTVIESNTLIYKTLADWSKVEDNRETIIRSPSNVIEKTFQLFEFLLPNGVETLNTDTTVEQSELFSMVCRLLGNLTYENAPNREFIFDKTPSILKYISSFVSQTKYQSLQRTSCAAIANLSSETDFIQLEFFKLGVVSILIDLICREGTTDEVNQMAIKAFNNLVDNENTQVDIHFKEIHRLLGQLKKSLNKEGYYENSFANDLVSSLSTLSLNKDLQKEILKEGFLNDLIELIEESNVHREMINQFEDDDIEKDKDISIAPSTSELIFKLADNDDYRQYFYNKERDGNDANNILDRMIKIMTSPPPAYKDGDSKAQLKALDVAKVKKNITKTIALCSLEDDVIDKFIKTPKIFVDLLVDTEDTERIVNGEMIIGNLARSEPNCRLLNSYNVIELIADIMKKFPNFQPIQHLGLSSIRNLTLPTINKGFKPSSTLMEDVVFNSKVHNQVIQFAALSLIKNFIGCDQSNLKLFLEFPNALQSLLDLANGRVPASMDDESDQQEQLQLDDAKIQEIEEKFEEKEKTIEKTDEKTDEKTNEKKQSKKDMRVIYEATRLLLRFLDNSELSNHQEKMKQLIEESVEPFFSLLQSPFPILQVEGAKGLVLLIKHDKQLFLSRPSWVKDLVEVLSLSIIPFQQLSREQSTITTDPNHQKLIAQIQSNCNFSTELQNVILSNIFYNFSLDESICKKMKDQNVISELKTLKSKQDAPQSLTNLIQKILVQLTI
Protein: Serine/arginine-rich splicing factor SR30 (At-SR30) (At-SRp30) (AtSR30) (SF2/ASF-like splicing modulator Srp30) (Serine-arginine rich RNA binding protein 30) (Q9XFR5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory splicing factor that modulates alternative splicing and gene expression in specific cell types. Autoregulates its own expression. Probably involved in intron recognition and spliceosome assembly.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:15034145, ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:23132568}. Nucleus, nucleoplasm {ECO:0000269|PubMed:15034145, ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:23132568}. Cytoplasm {ECO:0000269|PubMed:23132568}. Note=Inhibition of phosphorylation causes suppression of nuclear localization. {ECO:0000269|PubMed:23132568}.
Interaction partners:
- Serine/arginine-rich SC35-like splicing factor SCL30A
- Serine/arginine-rich SC35-like splicing factor SCL30
- Serine/arginine-rich SC35-like splicing factor SCL28
- Serine/arginine-rich splicing factor SC35
- Nuclear protein-like
- Splicing factor U2af large subunit A
- Serine/arginine-rich splicing factor SR45a
- RNA-binding protein Y14
- Serine/arginine-rich splicing factor SR45
- U1 small nuclear ribonucleoprotein 70 kDa
Sequence:
MSSRWNRTIYVGNLPGDIRKCEVEDLFYKYGPIVDIDLKIPPRPPGYAFVEFEDPRDADDAIYGRDGYDFDGCRLRVEIAHGGRRFSPSVDRYSSSYSASRAPSRRSDYRVLVTGLPPSASWQDLKDHMRKAGDVCFSEVFPDRKGMSGVVDYSNYDDMKYAIRKLDATEFRNAFSSAYIRVREYESRSVSRSPDDSKSYRSRSRSRGPSCSYSSKSRSVSPARSISPRSRPLSRSRSLYSSVSRSQSRSKSRSRSRSNSPVSPVISG
Protein: Large ribosomal subunit protein mL42 (28S ribosomal protein S32, mitochondrial) (MRP-S32) (S32mt) (39S ribosomal protein L42, mitochondrial) (L42mt) (MRP-L42) (P82927)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123}.
Interaction partners:
- MRPL41 protein
- Small ribosomal subunit protein mS29
- Coiled-coil-helix-coiled-coil-helix domain containing 1
- Small ribosomal subunit protein bS18m
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein mS39
- Large ribosomal subunit protein uL1m
- Alpha-ketoglutarate dehydrogenase component 4
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS14m
Sequence:
MALAAVKWAISSRTMLKHLFPVENGALYCVGHKSTYSSLPDDYNCKVELALTSDARTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDLVLKTRLEEKSEHLEQGPMIEQLSKMFFTTKHRWYPRGQYHRRRRKLNPPKDR
Protein: Vang-like protein (H2KY90)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- LIM zinc-binding domain-containing protein
- DiSHevelled related
- DiSHevelled related
- Cadherin EGF LAG seven-pass G-type receptor fmi-1
- Segment polarity protein dishevelled homolog mig-5
- Frizzled-4
- Frizzled-4
- Tyrosine-protein kinase receptor cam-1
- Inactive tyrosine-protein kinase RYK
- Protein Wnt
Sequence:
MSYQDNRKLPKDTRSCVGGFRYEGHKKQLRPRYAQSEIGEPFIPRFSAIASEGQKIAPPNEDWADNTTVLTGMTTDSFTMEEKVIYTPPIGRVIGRRCSRFVWLLASSLLCIISVVSAPIMCSLPIIAPRFGFSMPAIQCDVDCEGLLFLMAIKTIFLVIAIGVLYWRKAMADMPRLYFVRAALTFLVMFILFAFWLFYIVRIMFERYDNYKYIVSYSTSLLDALLWTHYLSVVLLELRRLRAQFIVTIVRDPDGEMHTLNIGAGSIQEAATEILRFYTTRFSSFNIHLDNARQTAVAKQSGMQGGTAGFKMYNIEQFGGQETVSEVNTRALMEAAARRRIGGYAEVMQEELDFEKRLKKRKYRLIAAAEDAFSHVQNTAESGTNQKPGINNQMDSLTAAQNVFTWIVRPLTKYLKTTRLQSRHPSGEVTRHIERCLTLKLSHRTFLQRFFSDRIPQREIVGESKWSVICDEAVSSGVQHGTYLVLKSHNPDIDCGVQLVCTISSIPFFNLTEQAKPGNEKFSLKISNESAV
Protein: Calcium-dependent protein kinase 32 (EC 2.7.11.1) (Q6NLQ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger. Involved in maintaining Ca2+ homeostasis in pollen tube tips by regulating CNGC18. Functions as regulator of the calcium-mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA-responsive transcription factor ABF4 in vitro.
Subcellular location: Nucleus {ECO:0000269|PubMed:16299177}. Membrane {ECO:0000305|PubMed:16299177}; Lipid-anchor {ECO:0000305|PubMed:16299177}.
Interaction partners:
- Cyclic nucleotide-gated ion channel 18
- ABSCISIC ACID-INSENSITIVE 5-like protein 7
- ABSCISIC ACID-INSENSITIVE 5-like protein 4
- Respiratory burst oxidase homolog protein D
- Protein NLP7
- Protein NLP6
- Calcium-binding protein CP1
- Putative DNA repair protein recA homolog 4
Sequence:
MGNCCGTAGSLAQNDNKPKKGRKKQNPFSIDYGLHHGGGDGGGRPLKLIVLNDPTGREIESKYTLGRELGRGEFGVTYLCTDKETDDVFACKSILKKKLRTAVDIEDVRREVEIMRHMPEHPNVVTLKETYEDEHAVHLVMELCEGGELFDRIVARGHYTERAAAAVTKTIMEVVQVCHKHGVMHRDLKPENFLFGNKKETAPLKAIDFGLSVFFKPGERFNEIVGSPYYMAPEVLKRNYGPEVDIWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVLDFRRDPWPKVSENAKDLIRKMLDPDQKRRLTAQQVLDHPWLQNAKTAPNVSLGETVRARLKQFTVMNKLKKRALRVIAEHLSDEEASGIREGFQIMDTSQRGKINIDELKIGLQKLGHAIPQDDLQILMDAGDIDRDGYLDCDEFIAISVHLRKMGNDEHLKKAFAFFDQNNNGYIEIEELREALSDELGTSEEVVDAIIRDVDTDKDGRISYEEFVTMMKTGTDWRKASRQYSRERFNSISLKLMQDASLQVNGDTR
Protein: Ethylene receptor 1 (AtETR1) (EC 2.7.13.3) (Protein ETHYLENE RESPONSE 1) (Protein ETR1) (P49333)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. In the presence of ethylene, the auto-kinase activity of ETR1 is inhibited and the non-phosphorylated kinase domain binds tightly to the corresponding domain of EIN2.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11916973, ECO:0000269|PubMed:19769567}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Serine/threonine-protein kinase CTR1
- Protein REVERSION-TO-ETHYLENE SENSITIVITY1
- Ethylene-insensitive protein 2
- Protein RTE1-HOMOLOG
- Histidine-containing phosphotransfer protein 1
- Protein ETHYLENE INSENSITIVE 3
- Histidine-containing phosphotransfer protein 3
- Ethylene-overproduction protein 1
- ETHYLENE INSENSITIVE 3-like 1 protein
- Ethylene response sensor 2
Sequence:
MEVCNCIEPQWPADELLMKYQYISDFFIAIAYFSIPLELIYFVKKSAVFPYRWVLVQFGAFIVLCGATHLINLWTFTTHSRTVALVMTTAKVLTAVVSCATALMLVHIIPDLLSVKTRELFLKNKAAELDREMGLIRTQEETGRHVRMLTHEIRSTLDRHTILKTTLVELGRTLALEECALWMPTRTGLELQLSYTLRHQHPVEYTVPIQLPVINQVFGTSRAVKISPNSPVARLRPVSGKYMLGEVVAVRVPLLHLSNFQINDWPELSTKRYALMVLMLPSDSARQWHVHELELVEVVADQVAVALSHAAILEESMRARDLLMEQNVALDLARREAETAIRARNDFLAVMNHEMRTPMHAIIALSSLLQETELTPEQRLMVETILKSSNLLATLMNDVLDLSRLEDGSLQLELGTFNLHTLFREVLNLIKPIAVVKKLPITLNLAPDLPEFVVGDEKRLMQIILNIVGNAVKFSKQGSISVTALVTKSDTRAADFFVVPTGSHFYLRVKVKDSGAGINPQDIPKIFTKFAQTQSLATRSSGGSGLGLAISKRFVNLMEGNIWIESDGLGKGCTAIFDVKLGISERSNESKQSGIPKVPAIPRHSNFTGLKVLVMDENGVSRMVTKGLLVHLGCEVTTVSSNEECLRVVSHEHKVVFMDVCMPGVENYQIALRIHEKFTKQRHQRPLLVALSGNTDKSTKEKCMSFGLDGVLLKPVSLDNIRDVLSDLLEPRVLYEGM
Protein: ZAP3, isoform C (Q9W2Y5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWGQWQTAAAVAPTAALPPQPSVPPPLPDAPPPPPPSDATAGAGASSGASAPIVTTAAAVTTAPGFNPYSSGQATGAGNPYQQYTAAQYAAMTPEQQYALQHHWQQWQTYQEEYAKWHAQYGEQYKREMAAAAATTTAVQGVPAPVVATPAAAPVPVVAPPGPQAYPVAHNYYQGVSASPAQSTTPVAVAGAPPLPGKIMAQPQMYNQPPPPPQKGGYNQHPNDIQSMWSGPPPMQQPPPNRYGGGQMNQMNYNIAGQDNQGFPNLQQPPPSLQRPTPQQQQPHLNHMDHGQWGNNQHGVGNNNRPTWDTSGPPPDNTGQPNRWNGPPPANDVNNRWNGTSFNNNTNDGNRRWDGTSNQAPSGGDQQLNRWMSEPPPSLPNPNQQYQNQNSWMSGPPPSISDPPQDHQQQNNSSQNARSSRWQGINSDIDTPPMRTNNKPNSIQNSRNSWGDGGGDGNQSKNPFIKNPQSDFGNYGNSYNSQDQGSAGGGNFGGFGDDSGGKQSQDSFAGRGGGPGNNINNNFSNNRRQNNRRDNNRNQGFSDERGGGDSGPGGYNPNRGNYNQRNSFNQSNAPYKQSQQNRNQQQPPDLDEASFDLLFDQWEQQFEEWKLANANHPDRDEYRRYEEEFEKQRRRIAERREQMRRRRQLQMGGSAGGSTTDIRKEAAAGASTTAEQKPNKDPFEGQGRFADQGDQDHGSGPNFGNGNRQSGNAGHFGKENRPFESAGVPAFRGNQGPPPGMHNQYQTAQEAIQQILDEQPDESNQEIPTKPAASNENSSDVKKAKTTASPVAPPIAPVVPPEVKAPAAPVVPDPTVVPPTQPPPVSTNYGKRRQRAAPSQIPAKQVKEEEPIFTISLDDDDDDDEEKEVVQDAPNTPMGSIFKKNDGIPGLDLVDDGSNKNNSSSVFNVVLKDSSEKKAADETEKQPGDVSADKKGDESLSNALKDPNFINNLSQAVANVQEREQRDRHEQRDDQESGTDGRPLSFAEWQRKKNSGNENKSQDAGDSVSTNNGEKPDNNGPPGGFGPGNGPGGGPGSGPGQNDGSRFDVFGPNQVSGNNFIDLDNNGPPGFGPPGRNFGPNGPGPRGNFGPNFGHNFGPRGPGGPFIRPNGPLPGPGPNFGPHFRPNGPNFGPNFGPNFGPRPGSRNFGPRGPDGPFGPGRDDFGGPPFGGPRPHMGPNGPGHNMRGFNGGPISDNPFRRQGGPPGPGFGNDDLGAGPPRGPRNFGNRFGNPGGGGGGGGGGGNNNRKNWNDGPEQQQFHDRLNHNDAIYRPLKVFDYSNNPTAAKVIDYGHKSGDGNPIDGPSGSNPDDRIPEFKAMKTFEYGHSSYMGSNRLGMPGGMGGGGDHNQAMTGGRGMAAGPGRFGGPGGAGNKRKNKKKNKQQKNGELMTFNQNQQMQSNTVEERSITNPEQDEERAHNELRNQNQADEFQKNEERNDLEDISEGEDNLQSIVFDDDNEELPPPPSMKIWNQGNAQEQYNPFPVNPLRRQLGDYSDKLEAPSPAMSLFPSAANANDRTSDPMKASNLEMCVATSENRNTFSLDEVLLYPGRLNRPKRICIILRGPPGCGKSHVARLIKEKELEMGGANPRILSIDDYFLIENDYDEKCPKTGKKIPKKEILYEYDDTMEETYMQYLIKSFKKTLSDNLYDFVIVDCNNNSLRTLNEFYCHAKDSNFVPYIVDLHCDLETCLGRNSHQRSVNDIRVVLDNWCQTPTHYIKLDVSSLLENVVEMEDVEDMATDDNACADVGATVGESAALEDAAVEETDDSNSADASNYCGFLKSKWERDTTEDNLARLDGTKRLMQNRRTTSMADYLQLEDWKPPTTSDNGKKRVRWADIEEKRSQKKMRAIGFVVGQTDWNRMMDPNAGSRALNKTKFIERIKRR
Protein: TBC1 domain family member 1 (A0A8I6AB45)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEAITFTARKHPFPNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSGQCSKKEPGMKQVRLWVSPSGLRCEPDLRKSQPWDPLICSSIFECKPQRVHKLIHNSQDPSYFACLIKEDAAHQQSLCYVFKADDQTKVPEIISSIRQAGKIARQEELRCPSEFDDTFAKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSCGRRIDWDAPTGQPSAPGARPMRKSFSQPGLRSLAFRKEFQDASLRSSTFSSFDNDIENHLIGGHNVVQPTDMEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRECSGGGGAGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQAMIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHSHTGEPKQTLQVAAENIGSELPPSASRFRLDSLKNRAKRSLTESLESILSRGNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDKEALPISESSFKLLGSSDDLSSDSESHIAEESALLSPQQAFRRRANTLSHFPVECPAPPEPAQTSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDTDGTPVKARRHSWRQQIFLRVATPQKACDSPSRYEDYSELGELPPRSPLEPVCEDGPFGPVQEEKKKTSRELRELWKKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKVHSAVGQGVPRHHRGEIWKFLAEQFHLKHPFPSKQQPKDVPYKELLKKLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEYEIGPSLYAAPWFLTVFASQFPLGFVARVFDMIFLQGSEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTISQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANARIQSLEVTVEKLLTSESKLKQAVLTLEMERSALLQMVEELRRQMAQPSTAEPDCTRLEPTGD
Protein: Regulatory protein VanR (VanR) (VanRA) (Regulatory protein VanRA) (Q06239)
Organism: Enterococcus faecium (Streptococcus faecium)
Function: Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSDKILIVDDEHEIADLVELYLKNENYTVFKYYTAKEALECIDKSEIDLAILDIMLPGTSGLTICQKIRDKHTYPIIMLTGKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQLRRYKKFSGVKEQNENVIVHSGLVINVNTHECYLNEKQLSLTPTEFSILRILCENKGNVVSSELLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTIDNPKYIKTVWGVGYKIEK
Protein: Uncharacterized protein (Q38AN8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPATFSQCFPDPLSSQWPATNHPVLCECRQLYVLVSVCCCVPSAHLLVLHDGACNTTVTSMPKGPTYLELRLTEQTSSETFCSFVSRAETASSTGNNIVEGKQRPVNIICLTGLAAATPSVQSAIMDVLQFSVVRVGGEVRRVPSLRIVAYCDARVFATAVPEWLRAGFALSTYMSSFTMESAAVIQSTDNDESNVVNRRNMLEVMLSEDGCELVDTVTLSCEVSRYLRHLLIVLRGAMLHHSVPGCYIPGRVPLLFRLLKVVALLFARPLLSRAREPPFSLRSPALLKYQRQQRQEQLPRDTTPITSFVHVMVSPAHVMGLLCPMVAHLFTIRREMATTRIGDIVHGYTNSGHFVPNIMISAGGGDGVSGNSNSNSVENDDNRAGGELSLTVFEMLDSVALRWLSQEAGQRETEQKTAGRGMNGIRGSTNVGLHASRESLDKVLSYPECRELICVTVIKHSAPPSG
Protein: Lucifensin (Lucifensin II) (B3EWY5)
Organism: Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Function: Shows strong antibacterial activity against the Gram-positive bacterium M.luteus. Also shows antibacterial activity against the Gram-positive bacteria E.fecalis, S.aureus, S.carnosus, S.pneumoniae and S.pyogenes and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates (By similarity). Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis (By similarity). Shows slight antifungal activity against C.albicans (By similarity).
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00710, ECO:0000269|PubMed:23802451}.
Interaction partners:
Sequence:
ATCDLLSGTGIKHSACAAHCLLRGNRGGYCNGRAICVCRN
Protein: Truncated Kidins220 isoform m2 (A0A076N8A1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
VRAAREQINIGGLAYPPLPLHEAPPRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSSVKTSLPRDQNNGLEVIKEDAAEGLPSPTASSRLCDSGFNKQRQASVPATGTSLLLSSMTVDIVCEKLRQIEGLDQGMLPQYCTTIKKANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSAPVAHGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSNLEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSICSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTGFGEERESIL
Protein: Insulin-like growth factor 2 preproprotein (Q2F6J9)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
LLETYCATPAKSERDVSASTTVLPDDVTAYPVGKFFQYDIWKQSTQRLRRGLPAFLRARRGRTLAKELEALREAKSHRPLIALPTQDPATHGGASSKASSD