wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein At3g57990 (Uncharacterized protein T10K17.200) (Q9M2P9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKASMKFREEQKPLFRAKVPLSILGLPFQSGIVAGESKELSLNLSTFFESGPSLKVAYRPNDSWNPFSLIVKTGSGSFGSPISSSMLMSAEFNLLGQGNPSFMLHFKPQFGDFSIKKSHSSSGFERNLIKSMNGSVSEDDSSIEVVDTPAVNGCGGGFRKVTVLPSTSAGDIAGLLSGVEVAARTSLPVRGRAVLNFRWGVRVPTEIRRDFDPTAAISLRRFPFLVMNKIGIEHVDGADAKVTKSTGDPGKVSGPAQFTTSGDVAEVIEELRTENKQLKRAVEDLREVISNVRPYSPATIDYGSHSKYRESERNNNNNNNNNNNNNGRSRADRWSSERTTTSDYGGKKSKEEGNVAEELKKALKGAA
Protein: Transcription factor AP-2-alpha (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (C1K3N0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEDRYAKSSPTCWLRTDLPWGTHGPTPSWSPASRAA
Protein: Small ubiquitin like modifier 1 (B8ZZN6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKEAQWPTPAILALWEAEAGWITAGQELRPAWATWRNLISTKNRKSSQLGMEEEDVIEVYQEQTGGHSTV
Protein: Uncharacterized protein C4C3.09 (O43062)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-1,2-galactosyltransferase gmh3
- Probable alpha-1,2-galactosyltransferase gmh1
- Uncharacterized alpha-1,2-galactosyltransferase C1289.13c
- Probable alpha-1,2-galactosyltransferase gmh2
- Alpha-1,2-galactosyltransferase
Sequence:
MNFFKRLRLHTRLLLRSKFVLISLILLLNLGLLLGIQIYRDPAFPGSLISSAAYEFGLHKHGPYYNDNVDDLKRYTFMGLLTLPTSEHDVYFNATRVLVYKLKHHPETKSKYPVHVLVMKGVDEWKIERLRLDGAEIIMVDQIKTEDLIESGLSIGMGSYRYQYMFTKLSVFEQTQFDKVCILDSDLLVLKNMDDIFDTPYVYESPAEPDMFSFPIFKKPDDEEDYQFSDNFDAYGAPRSEFYPYLLGACDDRNPGHATPPEESETFNAGLMLVHPSSLHMHRIKKIARYPYMYDDARMMEQSLLNLAYNKYGWFPWTRLDFSYNGVWVTEEDLPYLRAAHGKFWEYDNTEFPQILTAEWHKAFGELLAFHDYVVE
Protein: LIM domain 7 (A0A8I6AMI4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKNDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRLKNVLITLYWLGRKAQNNPYYHGPYLNLKAFETLLGQALTKALEDSSCLKRSGRDSGYGDIWCPDRGDFPAPPGSHRREDSFESLDSLGSRSLTSCSSDLTLRGGREGCESDNDWEFTFKMQDYNKDDMSYRRISAIEPKSALPFNRFLPNKSKQPSYVPAPLRKKRPDKNEDNRRSWASPVYTETEGTFSSTQRRAWGPKMENWHTVQETSTSSWCLEEEEEKVTRLPNVVKDDLYVRKLSPVMPSPGSSFDQFLPKGWTPEDMNWKKIKRETYKPWYKEFQGLSQFLLLQALQTYSDDILSSETNVKLDPTSGPRLITRRKNFSPTPGYRAHDLEPQSLDPDLENDDFFVRKTRAFHANPCVLRAFEDFRRFSEPDDAVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPDRYQPVPFPEPWTLPPEIQAKFLSVLERTCPPKDKPSSCRVLVPSHRLKKDDMLTRKIQSWKLGTAVPPISFRPGPCSEADLRKWEAIREASRLRHRKRLMVERLFQKIYGENGSKSLSDVSAEDVQSLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSDRSSKTFREMLQDRESQSSTTTSRRRIYSSDDILDDGVLPPTVTLSETSYQSERLEDKARAHPAEMPKEDSTTFASREDGIAAEIPLASHIPEERRQAPWPSAETRQASSSSAESHQASLPSTESDQARLPSAEPHQASFSSAEPRQVPLVSAEPHQASSFSSTEPHQASLSSALQRPSSLSSSQQSWSTRGESTRISASLPRSYQRSDTARLTSVVTARPFGTSSRGISSLPRSYTMDDGWKYNGDVEVVKREQHDSGRAAGMKPDSSHFILGSSSEKEVATGEDVASLSSFVLPSSSSLSHDQAASSKATFSSTSGLDSVSDSGEGRSSSLREVSRSPDQFSDMRISINQTPGTKHDFGFTIKWDVSGISVASVEKGSPAEFSQLQVDDEILAINNTKFSYKDTKKWEEAMANAQETGNLVMDVRRYGKSGSPETKWIDTTSGIYSTEKSSSLSVTTDFSESLQSPYSESKEINGIHEESNAFDSKASESISLKNLKRRSQFFEQGSSDSVAPDLPVPTLSAPSRWAWDQEEERRRQERWQKEQDRLLQEKYQREQEKLREEWQRAQQEAERENSKYLDEELMVLNSNSISLTSRESVTASWEPSWSEGSKSLDREGTRAGDEDRGQLEDDAVYEDQSQKLQERLMLEHEKKRKEQEAQEEELRKQREAEAQARAEAEAQARAEAQARAEAQAQAEAEARKRAEAQKLQAERERETSVKIYQYRRPIDSYDLPKREEESSGLLPIDRSKSRSTTELNDPLIEKSGSSKYSDRIGTTSFSQRSSKKDQGPSEAELERQQILQEMRKKTSLHNDNSWIRQRSASVNKEPICLTGIMRRGESLDNLDSQRPGSWRQSSWHSQPAGVYASSSVQDFSRLPPQLLSTSNRAYMRNPSSAVPPLAGSVKTSPGSPSPRSHSPSMSQSGSQLRNRSVSGKRVCSYCNSILGKGAAMIIETLGLCYHLHCFKCVSCERDLGGSSSGAEVRIRNHQLYCNDCYLRFKSGRPTAM
Protein: RNA helicase (EC 3.6.4.13) (A0A8I5ZT94)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSKRHRLDLGEDYPSGKKRAGTDGKDRERDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSGNRGRGTKTLALQSLGGLPFCWLPLLLLLLLLVVSSSSLLLLSMVIDFTDGFKELSLFPKYLVNSFIKIFTEVKFLMPKI
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (B1PS58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQFAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLSGSGPSGLMVKDEYDYDGPPSLPSTEGHMQTIQHPPSRAVTQEPFSTPALLPPAEGSSSASSSAFSSIAVGSTTQPGSVLSGSHSSDSLLQIASGTGQGSQQNGFPPGQTSTYHHNPTSSWSRNSNFTPSVPHHQNGHLQHHPPMAHPAHYWPVHNEIAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHMHRALQLLDEVLHTMPIADPTPLD
Protein: GDNF family receptor alpha-like (Q6UXV0)
Organism: Homo sapiens (Human)
Function: Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28953886}; Single-pass membrane protein {ECO:0000269|PubMed:28953886}; Extracellular side {ECO:0000269|PubMed:28953886}.
Interaction partners:
- Growth/differentiation factor 15
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Glial cell line-derived neurotrophic factor
- Persephin
Sequence:
MIVFIFLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCKMRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKEDKFKWNLTTRSHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGNPCDLKQCQAAIRFFYQNIPFNIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCKAAYIDILGTVLQVQCTCRTITQSEESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGEVIYAAMCMTVTCGILLLVMVKLRTSRISSKARDPSSIQIPGEL
Protein: Putative ARF1 GTPase activating protein (O18358)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASPRTRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELEKMKAGGNRNAREFLEDQEDWNERAPITQRYNSKAAALYRDKIATLAQGKSWDLKEAQGRVGSNNSFSSGGSSNSSYQSRPSATGYGGNGGYQNGGGAEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGGKYAGFGFTREPPPKTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVASKVTDMGKRGWNNLAGSNISSRQGGYNDPNFEDSSAYQRSNSVGGNLAGGLGQQSGVSDSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDADWSGFEATNYQSSETSYQNAPSGGSTARRNMKLQDTSQKLSEGFESLDVKSVKPKTATASSANKGTARDDAWNLLMN
Protein: AP-1 complex subunit gamma (Q86B59)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MNSEHGFNPAFNMATIRQAFTEAVERVRMPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKHLRPPLLEKMPAMQISRISSQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAASAPVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLLQAAVQRSFQLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYVLDGQQQVEQTEVSGFPEQQPAPAAAE
Protein: RE26756p (Q8MQZ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPAVEETQITKYLSKYKYVAATKKDVVDVVTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVYKNNTYYIPICIWLMDTHPQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLIQVMIVTFGDHPPVYSKPKEQIAAPYPTNSYMPQPGAPGGSNSFLPYPTAGGAGGSNFPPYPTGSNVGPYPPTPAGPAGGSGYPAYPNFIQPTAGGYPPAAGYNPSNPSSTGTITEEHIKA
Protein: Serpin 38F, isoform B (X2JAJ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKYLCLLLLATSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAAKFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKSDFHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLININVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATVFRYKSIRSPPMDFNVNHPFAYVIRDAENIYFQGHFVNPEL
Protein: IS1167, transposase (A0A0H2UNM1)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MEHINHTTLLIGIKDKNITLNKAIQHDTHIEVFATLDYHPPKCKHCKGKQIKYDFQKPSKIPFIEIGGFPSLIHLKKRRFQCKSCRKVTVAETTLVQKNCQISEMVRQKIAQLLLNREALTHIASKLAISTSTSTSTVYRKLKQFHFQEDYTTLPEILSWDEFSYQKGKLAFIAQDFNTKKIMTILDNRRQTTIRNHFFKYSKEARKKVKVVTVDMSGSYIPLIKKLFPNAKIVLDRFHIVQHMSRALNQTRINIMKQFDDKSLEYRALKYYWKFILKDSRKLSLKPFYARTFRETLTPRECLKKIFTLVPELKDYYDLYQLLLFHLQEKNTDQFWGLIQDTLPHLNRTFKTTLSTFICYKNYITNAIELPYSNAKLEATNKLIKDIKRNAFGFRNFENFKKRIFIALNIKKERTKFVLSQA
Protein: Phosphatidylinositol transfer protein PDR16 (PITP) (Pleiotropic drug resistance protein 16) (SEC14 homolog 3) (P53860)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover. Regulates the release of fatty acids from lipid droplets.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:24403601}. Microsome membrane {ECO:0000269|PubMed:12869188}; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidylinositol transfer protein SFH5
- Pleiotropic ABC efflux transporter of multiple drugs
- Lipid droplet organization protein LDO45
- Oxysterol-binding protein homolog 4
- Oligomycin resistance ATP-dependent permease YOR1
Sequence:
MFKRFSKKKEAPEDPKNLINIDKPIKELPASIAIPKEKPLTGEQQKMYDEVLKHFSNPDLKVYTSEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLKDCIDRITMTLAWRREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYLKPGRQNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPGNSKIPPIGVGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVFDEPFVKYVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQSFGGIVGLSEVDLRGTHEKLLYPVKSESSTV
Protein: Thylakoid lumenal 17.9 kDa protein, chloroplastic (Q9SW33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000269|PubMed:11719511}.
Interaction partners:
- Membrane related protein-like
- Bromodomain testis-specific protein
- Glycine-rich protein family
- At2g05510
- DEAD-box ATP-dependent RNA helicase 55
- KIN14B-interacting protein At4g14310
Sequence:
MSLVASLQLILPPRPRSTKLLCSLQSPKQEQELSSTSPPISLLPKLISFALAISLTSFSPALAIPSLSSSQPLTTPFTQSKFVQTGLLNGKIRPCPSTNPGCVSTNPTSSSFSFPLTIPETDTQDPIEKLKEAIMSTQKNPKFVVLEDTPYGRYVEAEVEGGGFSRDVMEFLVKQDVVAYRCMATKVTFVYPFTTAFGDSKGQEERLKKLIDQLGWYAPTFESME
Protein: Phosphate regulon transcriptional regulatory protein PhoB (G3LTY8)
Organism: Edwardsiella tarda
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTIRILVVEDETPIRDMVSFVLEQNGYQPLEAESYDGALSQLCEPYPDLILLDWMLPGGSGIQLIKQLKREPATREIPVMMLTARGEEEDRVRGLEVGADDYITKPFSPKELVARIKAVMRRISPMALEETINLQGLSLDPVSHRVTAQDDAVEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHICRLRKALEGSGHDRMVQTVRGTGYRFSARF
Protein: Papss1 protein (B2RYI8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAEALPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATQEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTCRSHPYIKMILEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPAELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGILNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPTHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSDHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLVEYYKSLEKA
Protein: Aldehyde oxidase 4 (AO-4) (AtAO-4) (AtAO2) (EC 1.2.3.1) (Benzaldehyde oxidase) (Indole-3-acetaldehyde oxidase) (IAA oxidase) (EC 1.2.3.7) (Q7G191)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aldehyde oxidase with a broad substrate specificity. Involved in the accumulation of benzoic acid (BA) in siliques. Delays and protects siliques from senescence by catalyzing aldehyde detoxification in siliques. Catalyzes the oxidation of an array of aromatic and aliphatic aldehydes, including vanillin and the reactive carbonyl species (RCS) acrolein, 4-hydroxyl-2-nonenal (HNE), and malondialdehyde (MDA).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:19297586}.
Interaction partners:
- Nitrilase 1
- Nitrilase 3
- Nitrilase 2
- Aldehyde dehydrogenase family 3 member H1
- Aldehyde dehydrogenase family 2 member B4, mitochondrial
- Aldehyde dehydrogenase family 3 member F1
- Aldehyde dehydrogenase family 3 member I1, chloroplastic
- Aldehyde dehydrogenase family 7 member B4
- Aldehyde dehydrogenase family 2 member B7, mitochondrial
- Indole-3-acetaldehyde oxidase
Sequence:
MAGDDLVFAVNGEKFEVLSVNPSTTLLEFLRSNTCFKSVKLSCGEGGCGACIVILSKYDPVLDQVEEYSINSCLTLLCSLNGCSITTSDGLGNTEKGFHPIHKRFAGFHASQCGFCTPGMCISLYSALSKAHNSQSSPDYLTALAAEKSIAGNLCRCTGYRPIADACKSFASDVDIEDLGFNSFWRKGESREEMLKKLPPYNPEKDLITFPDFLKEKIKCQHNVLDQTRYHWSTPGSVAELQEILATTNPGKDRGLIKLVVGNTGTGYYKEEKQYGRYIDISHIPEMSMIKKDDREIEIGAVVTISKVIDALMEENTSAYVFKKIGVHMEKVANHFIRNSGSIGGNLVMAQSKSFPSDITTLLLAADASVHMINAGRHEKLRMGEYLVSPPILDTKTVLLKVHIPRWIASSTTGLLFETYRAALRPIGSALPYINAAFLAVVSHDASSSGIIVDKCRLAFGSYGGYHSIRAREVEDFLTGKILSHSVLYEAVRLLKGIIVPSIDTSYSEYKKSLAVGFLFDFLYPLIESGSWDSEGKHIDGHIDPTICLPLLSSAQQVFESKEYHPVGEAIIKFGAEMQASGEAVYVDDIPSLPHCLHGAFIYSTKPLAWIKSVGFSGNVTPIGVLAVITFKDIPEVGQNIGYITMFGTGLLFADEVTISAGQIIALVVADTQKHADMAAHLAVVEYDSRNIGTPVLSVEDAVKRSSLFEVPPEYQPEPVGDISKGMAEADRKIRSVELRLGSQYFFYMETQTALALPDEDNCLVVYSSTQAPEFTQTVIATCLGIPEHNVRVITRRVGGGFGGKAIKSMPVATACALAAKKMQRPVRIYVNRKTDMIMAGGRHPLKITYSVGFRSDGKLTALDLNLFIDAGSDVDVSLVMPQNIMNSLRKYDWGALSFDIKVCKTNLPSRTSLRAPGEVQGSYIAESIIENVASSLKMDVDVVRRINLHTYESLRKFYKQAAGEPDEYTLPLLWDKLEVSADFRRRAESVKEFNRCNIWRKRGISRVPIIHLVIHRPTPGKVSILNDGSVAVEVAGIEVGQGLWTKVQQMVAYGLGMIKCEGSDDLLERIRLLQTDTLSMSQSSYTAGSTTSENCCEAVRLCCGILVERLRPTMNQILENARSVTWDMLIQQANAQSVDLSARTFYKPESSSAEYLNYGVGASEVEVDLVTGRTEIIRSDIIYDCGKSLNPAVDLGQIEGAFVQGIGFFMYEEYTTNENGLVNEEGTWDYKIPTIDTIPKQFNVQILNSGHHKNRVLSSKASGEPPLLVAASVHCATRSAIREARKQYLSWNCIDDDHRERCDLGFELPVPATMPVVKQLCGLESIEKYLEWKTYP
Protein: Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) (P49069)
Organism: Homo sapiens (Human)
Function: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:31417168}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guided entry of tail-anchored proteins factor 1
- ATPase GET3
- Tumor necrosis factor receptor superfamily member 13B
- Peptidyl-prolyl cis-trans isomerase B
- Golgi to ER traffic protein 4 homolog
- Ubiquitin-like protein 4A
- Type-1 angiotensin II receptor-associated protein
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Fibrocystin
- Tumor necrosis factor ligand superfamily member 13B
Sequence:
MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP
Protein: HEPACAM family member 2 (C9JN07)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
MWLKVFTTFLSFATGACSGLKVTVPSHTVHGVRGQALYLPVHYGFHTPASDIQIIWLFERPHTMPKYLLGSVNKSVVPDLEYQHKFTMMPPNASLLINPLQFPDEGNYIVKVNIQGNGTLSASQKIQVTVDDPVTKPVVQIHPPSGAVEYVGNMTLTCHVEGGTRLAYQWLKNGRPVHTSSTYSFSPQNNTLHIAPVTKEDIGNYSCLVRNPVSEMESDIIMPIIYYGPYGLQVNSDKGLKVGEVFTVDLGEAILFDCSADSHPPNTYSWIRRTDNTTYIIKHGPRLEVASEKVAQKTMDYVCCAYNNITGRQDETHFTVIITSVGLEKLAQKGKSLSPLASITGISLFLIISMCLLFLWKKYQPYKGQKQNTGKLKHFQAMKMLWMTSEYMNLLLFQMFLVFPGSQAGLFQPLIVYRGKICTVQCMKLFSTSLPSSKTIQSELSWAKQYIRVKF
Protein: Protein flightless-1 homolog (Q9JJ28)
Organism: Mus musculus (Mouse)
Function: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11171324}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11171324}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11171324}. Cell junction, focal adhesion {ECO:0000269|PubMed:22581781}. Cell projection, podosome {ECO:0000269|PubMed:23525008}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localized to the core of macrophage podosomes (PubMed:23525008). {ECO:0000269|PubMed:11171324, ECO:0000269|PubMed:23525008}.
Interaction partners:
- Leucine-rich repeat flightless-interacting protein 1
- Leucine-rich repeat flightless-interacting protein 2
- Myeloid differentiation primary response protein MyD88
Sequence:
MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNHLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNGIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMMALQTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPSLRRLNLSSNQIAELSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAANNNLELIPESLCRCPKLKKLVLNKNRLVTLPEAIHFLTEIQVLDVRENPSLVMPPKPADRTAEWYNIDFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQEKNKNQEESIDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGSSLDPRFVFLLDQGLDIYVWRGAQATLSNTTKARLFAEKINKNERKGKAEITLLVQGQEPPGFWDVLGGEPSEIKNHVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQGQGLSGKVKRDTEKTDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGFVLEGRKFTRLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKTEDKEGKASAEAREGEEAAAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKVTQGTLQPTLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDASYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAWSTFRQAPA
Protein: 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) (EC 4.2.1.117) (Aconitate hydratase) (ACN) (Aconitase) (EC 4.2.1.3) (Q8EJW3)
Organism: Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle II (propionate degradation route). In vivo under anaerobic conditions, AcnD catalyzes the stereospecific dehydration of (2S,3S)-methylcitrate (2-MC) to yield the trans isomer of 2-methyl-aconitate (2-MCA). AcnD can also accept citrate and cis-aconitate, but with a lower efficiency. 2-methylisocitrate and isocitrate are not substrates.
Interaction partners:
- 2-methyl-aconitate isomerase
- 2-methylcitrate synthase
- 2-methylisocitrate lyase
- Superoxide dismutase
- Citrate synthase
- Large ribosomal subunit protein bL19
- Propionyl-CoA synthetase PrpE
- Fumarate hydratase class I
- Large ribosomal subunit protein bL28
- Large ribosomal subunit protein bL32
Sequence:
MSTVMNTQYRKPLPGTALDYFDTREAIEAIAPGAYAKLPYTSRVLAENLVRRCEPEMLTASLKQIIESKQELDFPWFPARVVCHDILGQTALVDLAGLRDAIAAKGGDPAQVNPVVPTQLIVDHSLAVEYGGFDKDAFAKNRAIEDRRNEDRFHFINWTQKAFKNIDVIPQGNGIMHQINLERMSPVIHARNGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAESVMLGRASYMRLPDIIGVELTGKPQPGITATDIVLALTEFLRAQKVVSSYLEFFGEGAEALTLGDRATISNMTPEFGATAAMFYIDQQTLDYLTLTGREAEQVKLVETYAKTAGLWSDDLKQAVYPRTLHFDLSSVVRTIAGPSNPHARVPTSELAARGISGEVENEPGLMPDGAVIIAAITSCTNTSNPRNVIAAGLLARNANAKGLTRKPWVKTSLAPGSKAVQLYLEEANLLPELESLGFGIVGFACTTCNGMSGALDPVIQQEVIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGLDKDGKPVRLINIWPSDAEIDAVIAASVKPEQFRKVYEPMFDLSVDYGDKVSPLYDWRPQSTYIRRPPYWEGALAGERTLKGMRPLAVLGDNITTDHLSPSNAIMMDSAAGEYLHKMGLPEEDFNSYATHRGDHLTAQRATFANPKLKNEMAIVDGKVKQGSLARIEPEGIVTRMWEAIETYMDRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKAGENRATYGIDGTEVFDVIGSIAPRADLTVIITRKNGERVEVPVTCRLDTAEEVSIYEAGGVLQRFAQDFLESNLK