Protein: Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (Q8C9B9)
Organism: Mus musculus (Mouse)
Function: Required for early embryonic stem cell development (By similarity). Putative transcription factor, weakly pro-apoptotic when overexpressed.
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis (By similarity). Translocates to the nucleus after pro-apoptotic stimuli. {ECO:0000250}.
Interaction partners:
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5
- WD repeat-containing protein 82
- Protein dpy-30 homolog
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- SUMO-conjugating enzyme UBC9
- Heat shock-related 70 kDa protein 2
- Histone-lysine N-methyltransferase SETD1B
- Histone-lysine N-methyltransferase SETD1A
Sequence:
MDDKGHLSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDTEVDPSEQQPQQHNLSLRRSGRQPKRTERVEEFLTTVRRRGKKNVPVSLEDSSEPTSSTVTDVETASEGSVESSSEIRSGPVSDSLGKEHPASSEKAKGGEEEEDTSDSDSDGLTLKELQNRLRRKREQEPVERSLRGSQNRLRKKRREEDSAETGSVQIGSAEQDRPLCKQEPEASQGPVSQSETDDIENQLEGKATQGNTEENPREAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETNGSATDEQDSGCRSVGADGTDCTSIGTVEQKSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAPKCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCSVQVGIKISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKPTALSPTLLSKSMKDDRRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPAIKKLPSGFKGTIPKRPWPSATLSGTSARQAGPTPMTAASKKLPGSAAVVGVTRKPMSANVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKKNTTKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTADEGIADTLPENASEPDPESTSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSGRDPRTALSGSCTVTASMAAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPPSPSISESRSPPEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGELDKTDEKRTRLQQEELETSVYPKVTAALPSEKKPPKYSVHSIDTAATSTTPPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTAPTTAAITTTASPVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLSPHQDSKAKGEDTMSAAPLLDPIVQQFGQFSKDKALEEEEEDDRPYDPEEEYNPDRAFHTLLAEPGRPHDVQSVSETAEREEVAYDPEDETILEEAKVTIDDLPNRMCMKVSATERPADFTTDASSASLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQAPDPSQGAPNTNHNLDSRQSRDPRQARRLAAENTENESLPRAPTGSTPGPQGTLPARETPAGTAVVQGPGLAAEAKESMAVPWAPGENAVLRPEHDIQKCEHPGNPVSLPLDTSHLPTAGDGAARPAPPRRVLLPTPPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFMSQETSLGSSQYEDPRGAQSAGKNDSPVADMEDSREPQPRPGESTTSFPQPGQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPYSEENLVPNSDGPRGPPPARFGAQKPPIPSLFSGQHGPPPYGDNRGLSPSYLGGPRGGAPAQFEDRKDPHGEKREFQDTPYNEMTGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLLTQMKGPRGGPPPSQFGAQRGPPPGHFVGPRGPHPSQFENSRGTHPGQFEGARGQAPGFMPGPRGIQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQPPSRFHFQGPSSQPVKPPPRPLLELPSHPPQHRKDRWDEAGPATALPSSAGPGQGHEADGQWATSEFREGKGHEYRSPAFEGRQRERFEAGSKEKPLDEPEAQGLESRQGRAFEDRRRERERGRNWSRERDWERSRDWDRHREWDKGRDRSSNRDRERDNDRAKEWDRSRERSRNRDRDRERRRDRDRSRSRDRDRDRERARDRDRDRGRDRKDRSKSRESPRDQKPEARTSEGGPAAAQA