wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) (Q9VUV7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase
- E3 ubiquitin-protein ligase CBL
- Epidermal growth factor receptor
- E3 ubiquitin-protein ligase Smurf1
- GH01161p
- E3 ubiquitin-protein ligase Su
- E3 ubiquitin-protein ligase Nedd-4
- E3 ubiquitin-protein ligase NRDP1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Endosulfine, isoform A
Sequence:
MGYDVNRFQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTANLRAVPRILRNLLSRLSITCDNAPYGCTAVLKLDAYNSHLDECIHNPKRPFPCEKGCGFDIPKDELKDHNCVRELRTLIVKQTEKMGELKSELTDQQLTINELKRELQLFKDFMRAMRVSNPAMRAIADQMERDEVIRWSSTLPRARVTRWGGMISTPDDALQLMIKRALSESGCPPHILDSLMEFCHERRWPRGLSSLETRQTNRRIYDNYVCRRIPGKQAVLVLSCDNLHMTEDVMIDPGLVMIFAHGIE
Protein: F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) (Q9VZF4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- S-phase kinase-associated protein 2
- Supernumerary limbs, isoform B
- RING-box protein 1B
- GEO01111p1
- Cell division control protein
- G1/S-specific cyclin-E
- RING-box protein 1A
- Cullin homolog 1
- FI11905p
- Cullin 3, isoform F
Sequence:
MERGCPAASSESVTSAGERTQSAVTSSTSTWVKSQASTSRKTEASEESGLGAVDAEVGAGREAFVSMSTLREDVEDVCVSSNSQHGFAVVLDDESSTFEISSSNSLPTSAGAASTVGVVAVDDSSSTDTLNGGHPDLGHPASSEHSRQGFFNEDNEDPPVVCLINDDDDDEEPEPEEDDEEELIEDEDEDAVDIVTGAISCPNTSQLALADGTIMAADGSKIFLETPVVEEAQPHPGQVVTTGSQSELTGKPKRLSDEFLLGEEDQAENLALGRCIKSEPVNPVDDNPSEGDDGATCFSLHDRLMSVRLKQMSLTANTVSNPSPAASANAAAPEEASTSNSSSTSSSALSRADIESMDLIERRDFETEQRLTGGIILRTSSMVSQNKLNLSLIKSMAGGSKAANGSGTANSDDWPSSSNGRTVSSDSKYTYKDLSTTPTSSRKYTNSRLSKSTAKLNLGSSLGASSCSQHRSGSSSTSKSMESSTSCTGAARTDVYTNTNSNDYPSLAPTTSGSSTSGGSCQQDQEENVSASVSYSSVGSQTSQESGCSRTTAINPTAACSTGSACLGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANPTASVRQRRNGSSDVVHLEVVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDFDVEGACVKCS
Protein: Bruchpilot, isoform D (Bruchpilot, isoform E) (Bruchpilot, isoform H) (A1Z7V1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAHAMDYPRTRYQSLDRGGLVDPHDREFIPIREPRDRSRDRSLERGLYLEDELYGRSARQSPSAMGGYNTGMGPTSDRAYLGDLQHQNTDLQRELGNLKRELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQKQAMLVRQLEEELRLRMRQPNLEMQQQMEAIYAENDHLQREISILRETIKDLECRVETQKQTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQLDEFRLEIQRRDQEILAMAAKMKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLERSQNVQKLMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQSDAERAREEAAALQEKLEKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFSEVEKIKEEMERTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDKLDKACTENRRLVLEKEKLTYDYDNLQSQLDKALGQAARMQKERETLSLDTDRIREKLEKTQVQLGRIQKERDQFSDELETLKERSESAQTLLMKAARDREAMQTDLEVLKERYEKSHAIQQKLQMERDDAVTEVEILKEKLDKALYASQKLIDEKDTSNKEFEKMLEKYDRAQNEIYRLQSRCDTAEADRARLEVEAERSGLAASKAREDLRKLQDESTRLQEACDRAALQLSRAKECEDNARSELEHSRDRFDKLQTDIRRAQGEKEHFQSELERVTYELERAHAAQTKASASVEAAKEEAAHYAVELEKMRDRYEKSQVELRKLQDTDTFGRETRRLKEENERLREKLDKTLMELETIRGKSQYESESFEKYKDKYEKIEMEVQNMESKLHETSLQLELSKGEVAKMLANQEKQRSELERAHIEREKARDKHEKLLKEVDRLRLQQSSVSPGDPVRASTSSSSALSAGERQEIDRLRDRLEKALQSRDATELEAGRLAKELEKAQMHLAKQQENTESTRIEFERMGAELGRLHDRLEKAEAEREALRQANRSGGAGAAPHPQLEKHVQKLESDVKQLAMEREQLVLQLEKSQEILMNFQKELQNAEAELQKTREENRKLRNGHQVPPVAAPPAGPSPAEFQAMQKEIQTLQQKLQESERALQAAGPQQAQAAAAAGASREEIEQWRKVIEQEKSRADMADKAAQEMHKRIQLMDQHIKDQHAQMQKMQQQMQQQQQAAQQAVQQAAQQQQSAAGAGGADPKELEKVRGELQAACTERDRFQQQLELLVTELEKSKMSNQEQAKQLQTAQQQVQQLQQQVQQLQQQMQQLQQAASAGAGATDVQRQQLEQQQKQLEEVRKQIDNQAKATEGERKIIDEQRKQIDAKRKDIEEKEKKMAEFDVQLRKRKEQMDQLEKSLQTQGGGAAAAGELNKKLMDTQRQLEACVKELQNTKEEHKKAATETERLLQLVQMSQEEQNAKEKTIMDLQQALKIAQAKVKQAQTQQQQQQDAGPAGFLKSFF
Protein: Shal K[+] channel interacting protein, isoform J (A0A0B4KHM3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAVSNIVCEWLRALGLAQYAESFLDNGYDDLEICKQVGDPDLDAIGVENPAHRHKLLKSIRSLREKGAASVYFMLNDPNSLSGSMEILCETPPNNELELVLREQLETDGVRLTAHPYSTPDGQRGHLEGLASVYCELLMAPFGDILATIERARQAAWAERSPLHSAAQVVGGSGGAGGSTGSGSGGAASGGSGGSSGVLHHRQQHGHRGHSMHGAGLPNSHSQPIYVPGKYSPSSCLSDKEEDEIYGFGYGVFAPRVARGGLTQQQQLLQQQTLQTQQSIQQQQQQMQQQQQQLPIVPGQQQQGPHQHQTLPPNVAHLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSFEETIHRLKVQEAMRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNGGGGGAAHYAGGRVRFSNNRESTGVISLRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTSMASCICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESNSLDDVVTKCSSEIMKRVESARRCKDNPFKTTLPGGGRLGKKSFLGGNGLMADDTLTRGGLSEKSSDSGVSSSSLSSGPLKSST
Protein: Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (Q54B44)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU365061}. Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
Interaction partners:
- X-ray repair cross-complementing protein 5
- ATP-dependent DNA helicase ku70
- Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein
- Probable H/ACA ribonucleoprotein complex subunit 4
- Replication protein A subunit
- H/ACA ribonucleoprotein complex subunit 3
- DNA 3'-5' helicase
- WD40 repeat-containing protein
- DNA repair protein RAD51 homolog
- DNA repair protein RAD50
Sequence:
MNIQNIYKEPNLLNRIFLNEKGYDVVTILRYIVLKIDQTNHNLDDSIKQVFNETTDPIDYRDFLLNSFVCLKAEIDTNTAQNNQNNQNNNNNNQNNNQNNNQNNNDNNNKQQTTLKRKIEQQKIPNNSFYKLLSLVKQIESKNVISLIGYTGETYQNTPIGYILTSPSFKRISERHFEILEDIFKNHYLFTRSTSNRNIYIQISGLPVSFFAKKNRYLQIQQQQQQQQQQHQQQQQQQQQQQQQNQQKQKILNKKENDYEKIESKTRLPSWIRKRNKKKEQQQLNKENQIKKRNEEQREKQTNLNKTNYKAIAKPSYRINNFIKDDEENERDNQIVHNHILYSMTPSSTFLPNKISKLLNNKQLIINGKISLNYTKKLLWYLLSQPLSSCISKQSKHNQKSLIDILPKKPNQIRIQSSFKPTLPIFSNIFQKLNNTKSYQHILDSLYTNYHFGSSSNNNNNNSTKSINIESTQIDLKSLINNNCPIDLVYRFLITITNRLFCKNKVWGSEYNQKCFNQGLIIFLNQTSNKKLKFNSFCKRFNLNQFLFGTNCSIIYFKRFMWWLFEEIIPSIIRNYFYCTESTDSLKLLYFRKVDWFKLAGIQSQNLSFKIYSEIYFVNKQTIENRKFGISSLRFIPKTSNLRPIVNSKNNNSTLPIFNENNSTISMVDFPESINDSLATFAFPILKFELLTNNNNNNNNNNNYNNNNLIGSSIFTKSDIYLKFKSIREEYEIFLNNNNNSTSSSSPSSSSSQGLKKKLYFMSIDISKCYDNIDQKKLFQILNEKVFLNEKYLVQNIVNFKMKKKSEYSPFINTTFFVSSLNNIPTLDESIRIHKNNQSETIIYDSKYQQIIEKNQLLHLFHSHIFNHYIRYSSKLFHQVVGIGQGSLCSPHLCSLLLGDLENEILLPLLNNNKNNNNNNNKNNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLEFNFLVRFIDDYLYVSTEIDNLKSFKNLFHNGITEYGVKANQSKTKYYYSDDENSGLIKRGDGDDNDQLFIAWCGYLINCKTFEVQKDYSRLSKKVNNDNFTFFNFNDNDVETNEQIEWRNKLFKFLISKLSDKAQPILLDLTINSLPTIFLNIYQVILFCAIKFHCWVNEFYWNLNFNANLILSQVISRISNFLFNQILKVNNNNKNNNNETQQQQQQFNFIILFEINWLTLYAFKRILKKKPTNYIQLIKQLKNRLNQLNNSSKTSYIQLKYKKTINDNLSIDILNIIY
Protein: Dynactin subunit 2 (F8VW18)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAELVRSLTFHLLFNGEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELL
Protein: H6 family homeobox 2 (Homeobox protein HMX2) (F1QTJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Si:dkey-73p2.3.
- Si:dkey-73p2.3.
Sequence:
MNNSEDSGSKCSPAPISSFTIQSILGTSNDGVRSAGKDSPKSQPRKRTLSVSSEDDCSAGEDSGDCYCSEPGVPESCNPHQPLNFCLGATKGLLPVQDGIDRRPHLTPSILPDYKEEQGRACSQMSPVSEDRQRDGPDKQNNSAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRENSLLRVPVPRSIAFPTPLYYPGSNLPALPLYNLYNKIEY
Protein: F-box only protein 30 (Q8TB52)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
Interaction partners:
- Cullin-1
- S-phase kinase-associated protein 1
- Ubiquitin-like protein FUBI
- F-box only protein 34
Sequence:
MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSKPREQISVKSSVPEIPHANGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLNTSVPNDMDEQQNARESLEDQNLKDQDHLYEEEIGAVGGIDYNDTNQNAQSEQNGSSDLLCDLNTSSYDTSALCNGFPLENICTQVIDQNQNLHGDSKQSNLTNGDCVASSDGTSKPSSSLAVAAQLREIIPSSALPNGTVQHILMPDDEGEGELCWKKVDLGDVKNVDVLSFSHAPSFNFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADIYHIDVGTQTFSLPSAILATSTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSIQGAKIIHDRHLRSFGVQPCVSTVLVEPARNCVLGLHNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL
Protein: Exosome complex component ski6 (Ribosomal RNA-processing protein 41) (O42872)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exosome complex component rrp42
- Exosome complex component rrp4
- Exosome complex exonuclease dis3
- Exosome complex component rrp46
- Exosome complex component rrp45
- Exosome complex component csl4
- Exosome complex component mtr3
- Exosome complex component rrp40
- Exosome complex component rrp43
- Exosome complex protein C1739.07
Sequence:
MSHFEILSLEGLRNDGRRWDEMRNFQCRIGIEPSENGSAFIELGNTKVLCIVDGPSEPVIKSKARADRTFVNVEINIASFSTIDVKKRFKSDRRIQLQCLALQNTFEEIIQTELYPRSQISVYLHVLQDDGAVMASCINATTLALIDAGIPVKDFVCCSTAGIVESDMLLDLNSLEESALSWLTVAVLGNIKKVVYMQLETSMHLDYLESVMNMAIAGSEHIYNTMQSAVRQSAKPALASLS
Protein: Voltage-dependent L-type calcium channel subunit alpha (Q90ZA7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane, sarcolemma, T-tubule {ECO:0000256|ARBA:ARBA00024012}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Membrane {ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}. Postsynaptic density membrane {ECO:0000256|ARBA:ARBA00034112}.
Interaction partners:
Sequence:
MVNESKNMYIPEDTLENHQGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPKHIPTPGAPLSWQAAIFAARQAKLMGTTGAPISTASSTQRKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYGFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLRERQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPAGEDDEEEPEMPVGPRPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLLKGKFFYCTDTSKQTQAECRGAYILYKDGNVGEPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSVVDIAITEVNPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIETEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRRSGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKSSDSSDSRLPIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVPSLRLEGSGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLISEGLGRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNILNANAPPNANGNLLPFIQCRDTGSQESRCSLSLGLSPATGSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL
Protein: Mitochondrial pyruvate carrier 2 (Brain protein 44) (O95563)
Organism: Homo sapiens (Human)
Function: Mediates the uptake of pyruvate into mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029, ECO:0000269|PubMed:29472561}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial pyruvate carrier 1
- Mitochondrial pyruvate carrier 1-like protein
Sequence:
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK
Protein: Achromobactin transport system permease protein CbrB (Q47085)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Part of the binding-protein-dependent transport system CbrABCD for uptake of the siderophore achromobactin. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Achromobactin transport ATP-binding protein CbrD
- Achromobactin-binding periplasmic protein
- ABC-type hemin transport system, ATPase component
- Ferrichrysobactin transporter, permease ATPase component
- ATP-binding component of iron-hydroxamate transporter
- Achromobactin transport system permease protein CbrC
- Vitamin B12 ABC transporter, ATPase component BtuD
- Periplasmic hemin-binding protein
- Vitamin B12-binding protein
- Iron-chelating periplasmic-binding protein
Sequence:
MSHAVIPTGRRIAPGQVLAGGGVCLLALAVLSLMVGPVWIAPSQVLGALWHPDPLNVSHILVTSTRLSRTLIAIVVGAGLAVAGALMQVLTRNPLASPGLFGINAGAMFFLIVCVSLFPKVAMSVWLWSAFAGAAVAGCLVWLIGTMGKGSLNPLRMVLAGAAITAMFAAFSQAMLVVNQEGLDTVLFWLAGSVADRELATVLPLMGYCLAALVGALLLSGQVNVLNAGEAIARGLGQRTGRIRLLMSLLVVALAGGAVAMAGSIGFVGLIVPHMARKLLPADHRWLLPGCALLGACLLLLADILARVVIVPQEVPVGVMTALFGAPFFIFLLRRGGRYG
Protein: Basic helix-loop-helix ARNT like 2 (H0Y5R1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSHQNPLTYLLSTRIEISASSGSREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL
Protein: Girdin, isoform B (LD40094p) (Q8SX64)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAGTATATPMEIDEFVNSSIISWLESCLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILVLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLERLTPQSMYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKKKLSLKIEQMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELTKQKLYEIEARVSTYERENASLLKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRIIDQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVVEKLVRNPETFKTVREIMLNVTREQLEEEEREGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPAQPSSQELRFEHKVRLSPARESAELTRIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVRMEHSSLKLQNTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPFASMLVRRVKKASSDLMNKVPSRNRRSWVDDARTNSQFVIGSESGGNESDNSNEEPLSIASDTHLLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQAQKLLKRQT
Protein: Rorc protein (B5DFL4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQDFQHLHPIVVQAAFPPLYKELFSTDIESSEGLSK
Protein: [Thr6]-bradykinyl-Val,Asp (Bradykinin-related peptide RD-11) [Cleaved into: [Thr6]-bradykinin] (L0PIN3)
Organism: Agalychnis dacnicolor (Giant Mexican leaf frog) (Pachymedusa dacnicolor)
Function: Induces relaxation of rat smooth muscle from tail artery (EC(50)=16.8 nM) and contraction of that from ileum (EC(50)=205 nM), urinary bladder (EC(50)=895 nM) and uterus (EC(50)=60.3 nM). Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2).
Subcellular location: Secreted {ECO:0000255, ECO:0000269|PubMed:24394432}.
Interaction partners:
Sequence:
MSFLKKSLFLVLFLGFVSFSICEEEKREDEEEENEREENKESEEKRNQEERPPGFTPFRVD
Protein: Protein DAL82 (P21705)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulator of allophanate-induced genes in S.cerevisiae.
Interaction partners:
- Transcriptional activator protein DAL81
- Allantoicase
- Ureidoglycolate lyase
- Urea amidolyase
- Allantoinase
- Nitrogen regulatory protein DAL80
Sequence:
MDESVDPVELLLRLLIRHKPHLKPYAYRQDSWQRVLDEYNRQTGSRYRQSRTLKTKFRRLKDLFSADRAQFSPSQLKLMGALLDEAPEHPRPRTKFGNESSSSLSSSSFIKSHPGPDPFQQLSSAEHPNNHSSDDEHSGSQPLPLDSITIGIPPTLHTIPMILSKDNDVGKVIKSPKINKGTNRFSETVLPPQMAAEQSWSDSNMELEICLDYLHNELEVIKKRQEDFECKVLNKLNIIEALLSQMRPPSQGDKI
Protein: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA reductase 2) (EC 1.1.1.34) (P12684)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway constitutes by the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). HMG1 and HMG2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate that is the rate-limiting step within the first mosule. The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:8744950}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- Hydroxymethylglutaryl-CoA synthase
- Mevalonate kinase
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- Protein NSG1
- Squalene epoxidase ERG1
- Squalene synthase ERG9
- Isopentenyl-diphosphate delta-isomerase
- Farnesyl pyrophosphate synthase
- Cell division control protein 48
Sequence:
MSLPLKTIVHLVKPFACTARFSARYPIHVIVVAVLLSAAAYLSVTQSYLNEWKLDSNQYSTYLSIKPDELFEKCTHYYRSPVSDTWKLLSSKEAADIYTPFHYYLSTISFQSKDNSTTLPSLDDVIYSVDHTRYLLSEEPKIPTELVSENGTKWRLRNNSNFILDLHNIYRNMVKQFSNKTSEFDQFDLFIILAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSLYTTHSLLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLIRDYLFYISSFIGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILSMKLEINIIHRSTVIRQTLEEDGVVPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLLLLINLYVFTDKLNATILNTVYFDSTIYSLPNFINYKDIGNLSNQVIISVLPKQYYTPLKKYHQIEDSVLLIIDSVSNAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQSNKIDDLVVQQKSATIEFSETRSMPASSGLETPVTAKDIIISEEIQNNECVYALSSQDEPIRPLSNLVELMEKEQLKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTRAVLVRRKALSTLAESPILVSEKLPFRNYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGGFNAHAANLVTALFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLVQSHMTHNRKTNKANELPQPSNKGPPCKTSALL