wanglab/gogpt-training-data huggingface dataset:
Protein: Paired amphipathic helix protein Sin3b (SIN3 homolog B, transcription regulator (Yeast)) (SIN3 transcription regulator family member B) (Q1LYM8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00810}.
Interaction partners:
- Histone deacetylase 1
- SDS3 homolog, SIN3A corepressor complex component)
- AT-rich interactive domain-containing protein 4A
- AT-rich interactive domain-containing protein 4B
- Mortality factor 4-like protein 1
- BRCA2-interacting transcriptional repressor EMSY
- PHD finger protein 12
- PHD finger protein 12
- BRMS1 transcriptional repressor and anoikis regulator.
- Histone deacetylase complex subunit SAP18
Sequence:
MAKIQAHSSTAKQINQIQDKAYVVQKQVQQQHFQKLKVEDALSYLDQVKIRFGNDPGIYNKFLDIMKEFKSQSIDTPGVINRVSQLFHGHPDLVLGFNAFLPPGYRIEIPKNGMAFLQSPFSSQVSPGAGRSTGSSVVSASSSAVVEAAGPAQNEAVTSPESIASSSGPPEQSSKLSLPLPNRESQSQPAATSVSPPTSEPSPVEFDSAISYVNKIKNRFLDNPETYRAFLEILHTYQKEQLEVKESRGRSTGGMTEDEVFSKVASLFKGQEDLLAEFGQFLPDAKRSLFTGGSLPLKKVEEEELNKQTKKRPRPMLLPHMTPLLKKKMKYSCSKDPSFASVGKHGVLREFTFFDKVRRLLKSQEVYENFLRCIALFNQEVVSGAELLQLVTPFLGKFPELYTQFKSFLGDKELSHVISGLSDRYMEGGGREVDYASCKRLGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRLSLEDQERFRLDDCLGGTSEVIQRRAVYRIYGDKAPEIIEGLKRSPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQGVNFKQNDMKALRSKSLLNEIESIYDERQEQSTEEGSVGQQGRDGTSTASTSEPHMIFNYEDKQILEDAASLIIYHVKRQPTIHKDDKDHIKRIIQHFAPDLFFARRGELSETEEFTDEEGEGEDGAAAGGGVSSTGQQQLNGESRRRRCTSPQSMDTSTVAHSINPEGEAVDLRDPEAEHQKEMDGVYNLFFVNNNWYFFLRLHQTLCSRLLKIYRQAERQLLEHRAEQNRERLLMGEGRREKANDLAMELRLKQPSEVELEEYYPAFLDMVRSLLDGNLESTQYEDTLREMFTIHAYIGFTIDKLIQNIVRQLQHLVSDEVCLQVTELYLAERKRGAAGGNLSSQCVRAAWEASYQWKAERVMAEENCFKVMFIQNKGQVTLTIELLDTEEAQGDDPLDVQSLSNYMEQYIGTETLCSQAEGYYFKPVFLPRNVRHFRGWQIKQVEAMRCRREWHRKMGVETAGNLDCRFKLNTHKMVFVMNSEDYMYRRGALVKARRSQHRVARAQHERFEQWHRGWLSEHVSPAAERSVQDWLMGEEDEDMIPCKTNCVSLQVKGLHVNRYQVHYNSKAPASP
Protein: Microtubule-associated protein (F1MEW3)
Organism: Bos taurus (Bovine)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU000686}.
Interaction partners:
- Glial fibrillary acidic protein
- Synaptophysin
- Nestin
- Neurofilament light polypeptide
- Neuromodulin
- Cyclin-dependent kinase 5
- Synapsin-1
- Neurotrophic factor BDNF precursor form
- Alpha-synuclein
- Doublecortin
Sequence:
MADDRKDEAKAPHWTSAQLTEASAQPHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSTDRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQPKDQPPALPLAAEETANLPPSPPPSPASEQTVPVEEDEGAEDQVGPLHRFPSHEPATSGERRRLLAPSISVSVPDDDPSNSDEEYYEHPLFSSQWTASSVLPSGPAQSAEAHLGREKEEETLESPVAEEEKPATLPEKECGAAKVSDQPKGLSEGQVESSAEAQVVPADSASAGAPQEKSVKEVTVTEVSPEVKTPSSAGEGLLTASKMEFHDQQELTPSPAEPLDKKEKEPETESKPGEDLKHAALVSELETTKTSPDKKDIQGTEEEKAPPTLFGHTLGASLEDTKPKTEPSLVVPDIGLPAEPTAAKEQKDWFIQMPTEAKKDEWGLVAPVSPGPLTPMKEKDVLEDIPKWEGKQFDSPMPSPFQGGSFTLPFDISKHEIVAAAASFAPALLQPDDQKSLEETGSPATAKDSSKVEEPQKDQPDKIAEAPASEAVAAPKDAHVSIVEECVPEKVSGEEKGMIKEESVQIKETPTLSEQESTLAEKEPHLKLEEKPTISDKEAMPKESEPPKLIDEETNIIQPSTEHTYSKKEEKGQEPPTDILKQDSFPVSLEQAVTDSAMTTQTLEKVMTEPTALSEKIATQELFEEKVADKDHKVEGVGVVTSAELDMPFYEDKSGMSKYFETSALKEEVTKSIQPGSDYYELSDTRESVQEAFDTVSPMHKDGDKALPEEEPQPSAPAQEAGYSTLAQSHPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPAVDKAPCFPTESKEEKEQAKEEKDTGEENARVETSCESPFLAKDYYKNGTVMAPDLPEMLDLAGTRSRLASVSADTDVARRKSVPSETVVEESSTGLPPVTDENHIIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKARRDLATDLSLIEVKLAAAGRVKDEVSAEKEASPPISGDKSGLSREFDQEKKASDKLDTVLEKSEEHADSKEHAKETEEAGDEVETLGLGVTQEQASARELTVAKDASPVMAEKAEKGLSSVPEVAEVEPSKKAEPELDLAVKKAEQGQLDIKISDFGQMASGLHVDAGEAAELKLEATQDLAPSSTAPPEVDAFMGVESSHLKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAIKLSVEIPCAPVVSEADVAADERADVQMEFIQPPKEESQETPDISITPSDVTEPLPEAARAEPAEAQSEEEEIEAQGEYDKLLFRSDTLQITDLGAPGVREEFVETCPGEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHAEEELEVEEAAEAQAEPKDGSPEAPASPEREEVGLSEYKTETYEDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKIAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGAESAQAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112) (P33893)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:19417106}.
Interaction partners:
- Aspartate--tRNA ligase, mitochondrial
- Glutamyl-tRNA
- Glutamyl-tRNA
- Asparagine--tRNA ligase, cytoplasmic
- Asparagine--tRNA ligase, mitochondrial
- Urea amidolyase
- Aspartate--tRNA ligase, cytoplasmic
- Glutamine--tRNA ligase
- Probable amidase
- Glutamate--tRNA ligase, mitochondrial
Sequence:
MLRLARFYSLARTKAIHSHGAPFRPEYALKCGLEIHTQLNTKNKLFSQSTNSATSLVDAPNHHTSYYDIALPGTQPVLNLEAILFAMKLSLALGSQVNSISQFDRKHYFYGDQPQGYQLTQHYRPFARGGKINLSKELDDIDESAKEIGILQLQIEQDTGKSHYTETDKDVITLVDLNRSNVPLIELVTKPDFSDIKQVRAFIKKYQNLVRHLHISSGDLETGAMRVDVNLSINEYARVELKNLPNTSSIINAIKYEYQRQVELISVGDTSSLMEPETRGWTGSSTVKLRSKETTIDYRYMPDPELPYINLAPDVISGVRGLMPQLPDDIMRILMKKPYQLSLKDAKILTYNSNQNDMYNHEALRSYYLDTFREFSKLAGERSNAKLPTNWIIHEFLGDLNKLQIPLAKAKEILPPPVFAQFLKLLHEEVISATSGKMLLFHILENFEQSNCQDLSIPDFSKLIEKFELHAINQVDPQELMDLCNDVIAQHTDDTFIRNLVTGKKKSSLKFLIGQGMRRSQGRIKANEFEKKFKEILNIQW
Protein: Probable Resistance-Nodulation-Cell Division (RND) efflux transporter (Q9HXW4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable Resistance-Nodulation-Cell Division
- Probable Resistance-Nodulation-Cell Division
- Probable Resistance-Nodulation-Cell Division
Sequence:
MSFNLSAWALQNRQIVLYLMILLGAVGALSYSKLGQSEDPPFTFKAMVVQTNWPGASAEEVARQVTERIEKKLMETGDYDRIVSFSRPGVSQVTFMAREDIHSSEIPELWYQIRKKISDIRATLPQSIQGPFFNDEFGTTYGNIYALTGKGFDYAVMKDYADRLQLQLQRIRNVGKVELIGLQDEKIWIDLSNTKLATLGLPLAAVQKALEEQNAVASSGFFETASDRVQLRVSGRFDSVEEIRDFPIRVGDRTFRIGDVAEVRRGFNDPPAPRMRFMGEDAIGLAVAMKPGGDILVLGKALETEFARLQQSLPAGLELRKVSDQPAAVRTGVGEFIRVLAEALVIVLLVSFFSLGLRTGLVVALSIPLVLAMTFAAMHYFGIGLHKISLGALVLALGLLVDDAIIAVEMMAVKMEQGYDRLKAASFAWTSTAFPMLTGTLITAAGFLPIATAQSGTGEYTRSLFQVVTIALVVSWFAAVVFVPYLGAKLLPDLARLHAQKHGGSADGYDPYATAFYQRFRRLVEWCVRYRKTVIVLTLAAFVGALLLFRLVPQQFFPPSARLELLLDIKLAEGASLRSTGEEVQRLEKMLQGHDGIDNYVAYVGTGSPRFYLPLDQQLPAASFAQVVVLAKDLESREALRKWLIERMNEDFPHLRSRISRLENGPPVGYPVQFRVSGEDIPQVRELARKVADKMRENPHVVNVHLDWEEPSKVVYLSIDQERARALGVSTASLSQFLQSALTGSHVSFFREDNELIEILLRGTEQERRDLSLLPSLAVPTENGRSVALSQIATLEYGFEEGIIWHRNRLPTVTVRADIYDDSLPATLVAQIAPTLEPIRAELPDGYLLEVGGTVEDAAKGQSSVNAGVPLFIVVVLSLLMVQLRSFSRMAMVFLTAPLGLIGVTLFLLLFRQPFGFVAMLGTIALAGMIMRNSVILVDQIEQDISHGLDRWHAIIEATVRRFRPIVLTALAAVLAMIPLSRSVFFGPMAVAIMGGLIVATVLTLLFLPALYAAWFRVKKDEARA
Protein: WUSCHEL-related homeobox 1 (OsWOX1) (Protein MONOCULM 3) (Protein STERILE AND REDUCED TILLERING 1) (Protein TILLERS ABSENT 1) (Protein WUS) (OsWUS) (Q7XM13)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription repressor required for the formation and development of tiller buds and panicles. Required for tiller formation and female sterility. Required for the early developmental stages of axillary meristem formation. Plays a role in maintaining the axillary premeristem zone and in promoting the formation of the axillary meristem by promoting OSH1 expression. Does not seem to be involved in maintenance of the shoot apical meristem (SAM).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:25697101}.
Interaction partners:
- Leucine-rich repeat receptor-like kinase protein FLORAL ORGAN NUMBER1
Sequence:
MDHMQQQQRQQVGGGGGEEVAGRGGVPVCRPSGTRWTPTTEQIKILRELYYSCGIRSPNSEQIQRIAAMLRQYGRIEGKNVFYWFQNHKARERQKKRLTTLDVTTTTAAAADADASHLAVLSLSPTAAGATAPSFPGFYVGNGGAVQTDQANVVNWDCTAMAAEKTFLQDYMGVSGVGCAAGAAPTPWAMTTTTREPETLPLFPVVFVGGDGAHRHAVHGGFPSNFQRWGSAAATSNTITVQQHLQQHNFYSSSSSQLHSQDGPAAGTSLELTLSSYYCSCSPYPAGSM
Protein: Thermotolerance protein (A4D9S5)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Splicing factor subunit
- Splicing factor 3B subunit 1, putative
- Splicing factor 3b, subunit 2, 145kD
- Splicing factor 3b subunit 4
- Pre-mRNA branch site protein p14, putative
- Pre-mRNA splicing factor, putative
- Small nuclear ribonucleoprotein E
- RNA helicase
- Splicing factor 3a subunit 3, putative
- Small nuclear ribonucleoprotein G
Sequence:
MSPPLSDRGFDASGKRQDMGPMDIEQEGPSTTKPVVGLLSQTLVSSPIIQLILPARLRSKHQNDVVFVGERHIQIKEALSGIHLEDVNSESDFDAYIMAAKVINVSTELPWEAQMKLAASKAAVTDPGSRQELPPQIMVLSLASRELVFLYFSSTSGHFIHHHRPLPNDVSTFERFGRNIAVEPRSRAVAVSASADYFGVFMLKKPPVLQAQMASSHLDPITEERFFRVEGDILFMEFLYPKAEDGDKIILLLLVSQNQVTQAICYEWHADETIRQASPRITKRFLPPEDTLPTMLIPLTKTSSFMLITTTSMAVYKNRLDPRRQPSRYPLPVPDREAKKAPLWTRWARPLRNWSYNQRHDDIYLCREDGRVFYLGIGNEGELENQAHLGQLCCDVDAAFDILDIGHEGGDLLLAAGTTGDGGLFVQKARDQPRCVQKFINWSPVTDSVIVSSGQDSSSSDTARDRLFVCSASSYGRGAIFELRHGLEAQIGLVVSLEDLSSTRDIWTMSDDINGGVYLLISDPVSSILLYLSADFGEEMCAIDEADSGLDFSTQTLAAGCTSSGVLVQITEKAILLGTTTKSTMRARFEFGSDQSVAVAAVHSSASLIASAVRTRHEMHLSLKSINIGQDQLHLSEIGQPLRLPHEPVSILIEVLGTFTLIFVGTGNGKVLIYSFEDSTMLLSEVSIDVENGDDLSKAIESLAVVAIDTDGPSQKYTILCGLRSGIFAPFEMTLGHGNTKCAIEVKPASPRRIGNTSVKIQSRGQFALLTCGHGFWQASCPRKDGVIDPNLHLQRIWVTDQNNPAYHPGNVHSFAMAKTIDPNIDGEADTLFCIADGQLLICTLDHAAKTVPRRIDLPGSASKLAYSNYLRSLIVAYTRAELDTESDPIRRLTRPFIEFVEPDTQHGVSKAVDVSEDGYSAWRPHGAAGEKISCILEWTPKKGDEEYHFIVIGTARKQQQERGRVIFLQASRSSSDSSRIECSVKYIHKFESPVYAIAPYGDFTLMVSTGHEIVPLEPKLSQTRRVRAARYPMLSPAISLSCHEPYVYMSTSRESLMVLKSSEDKLLLHAYDRQKHDGLSHIHIGGEFNLTVTTSRGGRVSILSENGITDNDKMMPVALCEAHLPSSVMKLSSGSKPSPFSRSSQVYYGTAMNGIAYRFLILDEKEWRLLRLLQNLCIRDPILCPFTPKRKRRRNPATNGIAEPQPSHMHIDGDILSRLVMRGPKYLTKMLTTQGFEDAAFPENGTAQATLELFTELSNNLLGESPDQVEKVMRWLEKAVHVEF
Protein: Vacuole membrane protein 1 (Transmembrane protein 49) (Q96GC9)
Organism: Homo sapiens (Human)
Function: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Modulates ER contacts with lipid droplets, mitochondria and endosomes. Plays an essential role in formation of cell junctions. Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity).
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17724469}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17724469, ECO:0000269|PubMed:28890335}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beclin-1
- Tumor protein p53-inducible nuclear protein 2
- Beclin-2
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Transmembrane protein 41B
- WD repeat domain phosphoinositide-interacting protein 1
- Autophagy-related protein 101
- Autophagy-related protein 13
- Phosphoinositide 3-kinase regulatory subunit 4
- RB1-inducible coiled-coil protein 1
Sequence:
MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQRLNSEEKTK
Protein: T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) (P56279)
Organism: Homo sapiens (Human)
Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269|PubMed:7987816}. Endoplasmic reticulum {ECO:0000269|PubMed:7987816}. Note=Microsomal fraction.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- DNA
- T-cell leukemia/lymphoma protein 1B
- RAC-gamma serine/threonine-protein kinase
- Protein p13 MTCP-1
- B-lymphocyte antigen CD19
- B-lymphocyte antigen CD20
- Pre-B lymphocyte protein 3
- Immunoglobulin heavy variable 4-38-2
Sequence:
MAECPTLGEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRREDVVLGRPMTPTQIGPSLLPIMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLPDD
Protein: Syntaxin, Qa-SNARE family (C0H5E1)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
- Protein transport protein SEC22
- Sec1 family protein, putative
- Syntaxin, Qa-SNARE family
- Alpha-soluble NSF attachment protein, putative
- Protein transport protein SEC20, putative
- Serine/threonine protein kinase, putative
- SNARE protein, putative
- Syntaxin-6, putative
- Syntaxin, Qa-SNARE family
- Syntaxin, Qa-SNARE family
Sequence:
MDRYDDFIKLCEKLNKNGNKFVDKKEEKRNVKDEFFITSSKVYTKLFSACEYIDNNTLKEYGLFLNSTSCSSIYFSKNKPKGKNKDHLLFLINNISEDIKNLEPQLQIHNDILNCLNNLLSIFVDIINKYDNNLSNYNLKLNTYTTFYFYDVKSLKCNFDFLNKLNTQIYGSDVYINKYKDNNSELHSSLQRGKHIKVNKKNENSFFIQDGDMISPGLNEDTHVHMNDMVVSQNNVTSNYTNDDINMYDHNNNNNNYVNNSTRGKDINFPTHLNNNDNIKIHKSNLRKRRDLNNNNNNNNNNNMKNKQVHFNTYNYLDEENNPGESHNNNIFYQNSLLNNNQKLEFKKYVDLFEKEENTYIIETKKKIAKISNLMNIFVNKIYEQNENLKMIETIIEESIDNVSQGNNYLTKIKNKKNINSLIFFFLICTSIFLFIIDFFK
Protein: Prion-like-(Q/N-rich)-domain-bearing protein (O01876)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-like domain-containing protein
- Large ribosomal subunit protein P1
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS9
Sequence:
MLKLLITVGLAVGTVYSLTCYNGSKTLAFQSVGETTEECPESSYCYNMSTSAMVMVNFVKAGCSRWRCMLAKDTCIFTTFQMVPVSLCCCSYDRCNVGGNPVYSDNPKQIQNGGGNSGNWNSGGNNNGASGGSWGNGNANNNNNNNNGGSNNNGWGNNNDWSSNYNYGGSNAANEPKMTKQTVAGDDSWNKNKWTNKQVEDMFKKSIDDRGDEIQLEDDFKKIDKNYKTQSVPQESLRTLSARKEVEKIPFVAGKSSGVGAKTTASPTTGKSKEIQL
Protein: Equilibrative nucleoside transporter 1 (mENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) (Q9JIM1)
Organism: Mus musculus (Mouse)
Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Equilibrative nucleoside transporter 3
- Equilibrative nucleoside transporter 2
- Sodium/nucleoside cotransporter 1
- Solute carrier family 28 member 3
- Sodium/nucleoside cotransporter 2
- Adenosine kinase
- Deoxycytidine kinase
Sequence:
MTTSHQPQDRYKAVWLIFFVLGLGTLLPWNFFMTATKYFTNRLDVSQNVSSDTDQSCESTKALADPTVALPARSSLSAIFNNVMTLCAMLPLLVFTCLNSFLHQRISQSVRILGSLLAILLVFLVTAALVKVEMDALIFFVITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAIASGSELSESAFGYFITACAVVILAILCYLALPRTEFYRHYLQLNLAGPAEQETKLDLISKGEEPKGRREESGVPGPNSPPTNRNQSIKAILKSICVPALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKSYFIPVACFLNFNVFDWLGRSLTAVCMWPGQDSRWLPVLVASRIVFIPLLMLCNVKARHCGAQRHHFVFKHDAWFIAFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFLLRALV
Protein: Diphtheria toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36) [Cleaved into: Diphtheria toxin fragment A; Diphtheria toxin fragment B] (P00588)
Organism: Corynephage beta
Function: Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.
Interaction partners:
Sequence:
MLVRGYVVSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
Protein: 5'-nucleotidase (EC 3.1.3.5) (Q96B60)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNCFKRIAWARMSR
Protein: Zinc finger protein DPF3 (A9LMC0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal muscle development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92784}.
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Actin-like 6B
- SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 2.
- Actin-like 6A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- AT-rich interactive domain 1B
- SWI/SNF complex subunit SMARCC1 isoform X1
- Brahma protein-like protein 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A
Sequence:
MATVIQNPLKALGDQFYREAIEHCRSYNARLCAERSVRMPFLDSQTGVAQNNCYIWMEKRHRGPGMAAGQMYTYPARCWRKKRRLHTPLDPQLRLCELRLEAELMAKREAPQTEATALEALLRGDGILDKRNNNAKEEETLLEIQRVLEADENGDGFHDDEDFEVDTPKRKHRNKGRGRGSGRRRTEAVANDDQDKPYVCDNRYKQKHNSKTADSVCGKRYKNRPGLSYHYAHTHLAEEEGEEERETEIPQSPPVHHENHKPQKAPDGSIIPNDYCDFCLGDSGSNRKTGQAEELVSCSDCGRSGHPSCLQFTDNMMQAVRTYQWQCIECKSCSLCGTSENDDQLLFCDDCDRGYHMYCLKPPMTQPPEGSWSCHLCQNLLKDKASGVEDP
Protein: ATP synthase subunit alpha, chloroplastic (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) (P56757)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01346}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01346}.
Interaction partners:
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit a, chloroplastic
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit beta, chloroplastic
- ATP synthase subunit c, chloroplastic
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit delta, chloroplastic
- ATP synthase subunit 9
- ATP synthase subunit 9, mitochondrial
Sequence:
MVTIRADEISNIIRERIEQYNREVTIVNTGTVLQVGDGIARIYGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLMIQEGSSVKATGKIAQIPVSEAYLGRVINALANPIDGRGKISASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTSLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYREQHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSQLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFSQFSSDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDGLEIGQVRKFLVQLRTYLKTNKPQFQEIIASTKTLTAEAESFLKEGIQEQLERFLLQEKV
Protein: Angiomotin-like 2a (A1YB07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Subcellular location: Recycling endosome {ECO:0000269|PubMed:22362771}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y2J4}. Cell projection, podosome {ECO:0000250|UniProtKB:Q8K371}. Cell junction {ECO:0000250|UniProtKB:Q8K371}.
Interaction partners:
- Merlin
- PATJ crumbs cell polarity complex component.
- NF2, moesin-ezrin-radixin like
- non-specific serine/threonine protein kinase
- Protein kinase C
- WW domain-containing transcription regulator 1
- Rho GTPase-activating protein 17
- Rho GTPase-activating protein 17
- Si:dkey-92j12.5.
- Protein kinase C iota type
Sequence:
MRTAEESSGTVLHRLIQEQLRYGNPTDPTLLAIQQQALRGGSSGGGAGSPRSSLESLTQEESLSPQLSARQEPQGQEHQGDFQHSESPVCHLYQLHTEELPTYEEAKAHSQYLAYQRGQIGLHQGSLESPGGVGGAEQDDSMWDAKREHARSLSERLLQLSLERNCAHDNIPMSSSHSYPQLSNNHSDTVVNEQSVHQPDQRGPPPEYPFMVRSPGYMLSHSQEHGHYYNEPPPAFHSQHYRLFPTQPQAPRHNGLPTLTPAGQDVNVGGYSIPANNFQMEQLIKENERLKREVDSYSEKAARLQKLEQEIQRISEAYETLMKGSAKREALEKTMRNKLESEIKRLHDFNRDLRDRLETANKQRAAIEVEDKSRHAFAKLVEQNEDHLRERERLEKETQHLRASGEEWKRRREALEQALITAQTRNRQLEEELRRKRAYVEKVERMQSALAQLQAACEKREALELRLRTRLEQELKSLRAQQWQAQTQHASPGSYLDLNVSSLQQQLREREEQVLALEADITRWEQKYLEESTMRQFAMDAAATAAAQRDTTIINHSPRNSPNSSFNEDLPSPNHRHQEMENRIRALYAQLLEKDAIIKVMQQRSRREQGRPELQGLRPARSVPSINTVATASTTRAKGKSLSDDQTAVASLPPLPHLLAKIQCRDSSTQCDSEEPSCKAEPADVAVSAPEPSTASSSESTSLKTTQISSAVENDMVEILI