wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/potassium-transporting ATPase subunit alpha (A0A060YK73)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta-2
- Potassium-transporting ATPase subunit beta
- Potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Uncharacterized protein
- Nucleoside-diphosphate kinase
Sequence:
LSIHKNIVAGESNHLLVMKGAPERILDRCSTILIQGKEQTLNDELKEAFQNAYEELGGLGERVLGFCHFQLPDDQFAEGFQFDCEEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLKIPVSEVNPRDAKACVVHGGELKDLSAEQLDDILAHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEEAENDIMKRQPRNPKTDKLVNERLISIAYGQIGMMQATAGFFTYFVILAENGFLPMDLLGMRVDWDNKIMNDMEDSYGQQWTYERRKIVEFTCHTAFFASIVVVQWADLIICKTRRNSILQQGMKNRILIFGLFEETALAVFLSYCPGMDVALRMYPLKPCWWFCALPYSLLIFLYDEGRRYILRRNPGGWVEQETYY
Protein: Vacuolar import/degradation Vid27 C-terminal domain-containing protein (Q57YE9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSFHKLFSSNNRSTRRELFSGSGLLYVKSDDCFVPIIEGKRMGSFSLILYENRSEQLPYSFVLVDEEEGEVLKQSLGSGLSLAHCYRECSVHWLSLVDGTFQNLAFKFVDLESGGSGEIVTRKFVEMYNRCTYSMLTQTPLDVSTAQDPIYEYIGQTSTYVAPEDDYSEPTYHLDLDRERVKATGSGNVCYSESMKHNRIVVVRETQNEVQLQAHSYDANGFEGRKPETIDLKSVQTCDGALIDDLERKLLLFSVEDSHLREVDLERGEVVQQFRTPVNLQRVTYSEHVARPEPIYTCLAKDVAFNVDLRIDPRKNIIVEDGMSLADYKLGSLRKPFTCHATSANGYLVIGDGTGSVRLYTGPPGSRRKDGSHNPKTAKTLLETKVPIVDIDVTANGQYVVAVCEKFLLLMRTACGNNGEKNGFTSRMGQDKPSPLRLQPTPAQLSALGGIEALKFTSGGFDRYEGNGEVCITACSGAYLFTWSLEAAKRAEETGRTCLSQAAAVQQEVINAGAKIANRIVYQTDKDIRMAPLVREEFRETGLRHFGWRSTSE
Protein: Homeobox protein Nkx-6.3 (A6NJ46)
Organism: Homo sapiens (Human)
Function: Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MESNLQGTFLLNNTPLAQFPEMKAPVCQYSVQNSFYKLSPPGLGPQLAAGTPHGITDILSRPVAAPNNSLLSGYPHVAGFGGLSSQGVYYSPQVGNFSKAGNEYPTRTRNCWADTGQDWRGGRQCSNTPDPLSDSIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSSTPRAPGGAGAGAGGDRAPSENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSLGAHSV
Protein: Drosomycin (Cysteine-rich peptide) (P41964)
Organism: Drosophila melanogaster (Fruit fly)
Function: Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi. It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology. Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway. Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system.
Subcellular location: Secreted {ECO:0000269|PubMed:9736738}.
Interaction partners:
- Dorsal-related immunity factor Dif
- Embryonic polarity protein dorsal
- Metchnikowin
Sequence:
MMQIKYLFALFAVLMLVVLGANEADADCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC
Protein: Protein SCM3 (Suppressor of chromosome missegregation protein 3) (Q12334)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Histone H3-like centromeric protein CSE4
- Histone H4
- Centromere DNA-binding protein complex CBF3 subunit A
- Histone H3
- RING finger protein PSH1
- Histone H2A.Z-specific chaperone CHZ1
- Inner kinetochore subunit MHF1
- Inner kinetochore subunit CTF19
- Nucleosome assembly protein
- Inner kinetochore subunit OKP1
Sequence:
MKTNKKISKRRSLKNLHGALKGLLKESGKKSESKIRKHSDCNPVHRVYPPNIEKRKTKKDDGISRPIAERNGHVYIMSKENHIIPKLTDDEVMERHKLADENMRKVWSNIISKYESIEEQGDLVDLKTGEIVEDNGHIKTLTANNSTKDKRTKYTSVLRDIIDISDEEDGDKNDEYTLWANDSEASDSEVDADNDTEEEKDEKLIDADFKKYEAKLSKRILRD
Protein: Prickle-like protein 2 (Q7Z3G6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus membrane {ECO:0000305}.
Interaction partners:
- Vang-like protein 2
- Vang-like protein 1
- Segment polarity protein dishevelled homolog DVL-1
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Ankyrin repeat domain-containing protein 6
- Cadherin EGF LAG seven-pass G-type receptor 1
- Disks large homolog 4
Sequence:
MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCIIS
Protein: Kinesin-like protein (Q385N8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNNSRICVAVRKRPIVDVDKDIVVAQSPHLVVNEPKVKYDLTPYTERHQFTYDCVLDENSNNALVYQHCCSKLIDTIFNQGNATCFAYGQTGSGKTHTMLGNDHEAGLYAIAAKEIFARSAPLNSDVYVSFYEIYGRKIFDLLNNKEKLVAREDADKVINICGLTEHKVTDIQGLFDIISRGSTYRAAGQTSANNESSRSHAVLQIEVRDPNNRRGKSIGRISFIDLAGNERGADTFDCDRKTRMEGAEINKSLLALKECIRALGMGKSHVPFRGSILTEVLRDSFVGNSRTTMIATISPTSTHCVNTLNTLRYTQRVKDLGGEAKAAPNEKAERRPVRRSKLFEAPPPLKARPEWVDNFSANDEERGAEEEANSQADVSKAPPKPRANKMVGSGATGGGAPSAGGANRGRPPKREVVVRDPKIATIVQNHISALDDDSDETDEDEEEAPAAGAVLDALAKSEEKQVRKVHAHVVEEIAKAEEKLVALHRRHIDAKMTGIKDEIRAIQAFEESDSVDEYVGRVRTLLVKQKQDVETILDLLNGITGMLREEEELSCTLNSSMKRRN
Protein: BTG3 associated nuclear protein (E9PJI6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCLPQQSGP
Protein: ABC transporter G family member 14 (ABC transporter ABCG.14) (AtABCG14) (Protein INSENSITIVE TO TEMPERATURE 211) (White-brown complex homolog protein 14) (AtWBC14) (Q9C6W5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Positive regulator of plant growth which acts as an efflux pump involved in the major root-to-shoot (acropetal) long-distance cytokinin (CK) transport via the xylem sap. Together with ABCG9 and ABCG11, required for vascular development by regulating lipid/sterol homeostasis. Involved in CK-dependent responses to oxidative stress such as hydrogen peroxide H(2)O(2).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24112720, ECO:0000269|PubMed:24778257}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Purine permease 14
- Purine permease 2
- Cytokinin hydroxylase
- Equilibrative nucleotide transporter 8
- Adenylate isopentenyltransferase 3, chloroplastic
- Purine permease 1
- Equilibrative nucleotide transporter 6
- Cytokinin hydroxylase
- ABC transporter G family member 11
- Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG7
Sequence:
MPQNCIAPRPEEDGGVMVQGLPDMSDTQSKSVLAFPTITSQPGLQMSMYPITLKFEEVVYKVKIEQTSQCMGSWKSKEKTILNGITGMVCPGEFLAMLGPSGSGKTTLLSALGGRLSKTFSGKVMYNGQPFSGCIKRRTGFVAQDDVLYPHLTVWETLFFTALLRLPSSLTRDEKAEHVDRVIAELGLNRCTNSMIGGPLFRGISGGEKKRVSIGQEMLINPSLLLLDEPTSGLDSTTAHRIVTTIKRLASGGRTVVTTIHQPSSRIYHMFDKVVLLSEGSPIYYGAASSAVEYFSSLGFSTSLTVNPADLLLDLANGIPPDTQKETSEQEQKTVKETLVSAYEKNISTKLKAELCNAESHSYEYTKAAAKNLKSEQWCTTWWYQFTVLLQRGVRERRFESFNKLRIFQVISVAFLGGLLWWHTPKSHIQDRTALLFFFSVFWGFYPLYNAVFTFPQEKRMLIKERSSGMYRLSSYFMARNVGDLPLELALPTAFVFIIYWMGGLKPDPTTFILSLLVVLYSVLVAQGLGLAFGALLMNIKQATTLASVTTLVFLIAGGYYVQQIPPFIVWLKYLSYSYYCYKLLLGIQYTDDDYYECSKGVWCRVGDFPAIKSMGLNNLWIDVFVMGVMLVGYRLMAYMALHRVKLR
Protein: 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit (P0ABW0)
Organism: Escherichia coli (strain K12)
Function: Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin.
Interaction partners:
- 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD
- 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenasepropanoate dehydrogenase)
- 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
- Flavodoxin/ferredoxin--NADP reductase
- Hca operon transcriptional activator HcaR
- Siroheme synthase
- Nitrite reductase large subunit
- Carnitine monooxygenase oxygenase subunit
- Nitric oxide reductase FlRd-NAD
Sequence:
MNRIYACPVADVPEGEALRIDTSPVIALFNVGGEFYAINDRCSHGNASMSEGYLEDDATVECPLHAASFCLKTGKALCLPATDPLTTYPVHVEGGDIFIDLPEAQP
Protein: ATP-dependent clpX-like chaperone, mitochondrial (mtClpX) (ATP-dependent unfoldase ClpX) (P38323)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase (HEM1), thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Up-regulates heme biosynthesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:9827555}; Peripheral membrane protein {ECO:0000269|PubMed:9827555}; Matrix side {ECO:0000269|PubMed:9827555}.
Interaction partners:
- Lon protease homolog, mitochondrial
- Heat shock protein 78
- Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
- Mitochondrial glycine transporter
- Probable glutathione-independent glyoxalase HSP33
- Mitochondrial chaperone BCS1
- Mitochondrial inner membrane m-AAA protease component YTA10
- Probable glutathione-independent glyoxalase SNO4
- Heat shock protein 104
Sequence:
MLKSASQNFFRAYSSRIGRYAATASGKLAQSRLSNIPTPKALKKFLDEYIVGQEIGKKVLSVAVYNHYLRINDKQKKGELQRQRELMEREKIADDRDEPIFSGNSESKAGWRNLQRQFNLAGREVDEDLELSKSNVLVVGPSGSGKTLLATTLAKILNVPIAITDCTQLTQAGYIGEDVEVCIERLLVNAEFDVARAEKGIIVLDEIDKLAKPAASIGTKDVSGEGVQQSLLKIIEGHKVEITVKRPVKHDIDGQKNQTTTKKDEVFVVDTSNILFMIMGAFVGLDKHIVKRIEDMKKIQKAGESVESSNSKEVEKERAKKFRFSNTLEQVELDNGKKVCALDLTTPTDLVSFGLIPELIGRVPIITALQPLQRDDLFHILKEPKNALLDQYEYIFKQFGVRLCVTQKALKKVAQFALKEGTGARGLRGIMERLLLNVNYDCPGSNIAYVLIDEATVDSLQETEHSLASQVDVKYYSGDEKDSLIRDVSEEDKKLGVMLEKELGHSANIHTPTIPKRSLT
Protein: Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1) (P29376)
Organism: Homo sapiens (Human)
Function: Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
Subcellular location: Cell membrane {ECO:0000269|PubMed:34646012}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- ALK and LTK ligand 1
- ALK and LTK ligand 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha
Sequence:
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
Protein: Polycomb group protein Pc (Protein polycomb) (P26017)
Organism: Drosophila melanogaster (Fruit fly)
Function: Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Promotes locus-specific chromatin compaction. Binds to (N(6)-methyladenosine) DNA and thereby might implement repression of specific loci.
Subcellular location: Nucleus {ECO:0000269|PubMed:27326929}. Chromosome {ECO:0000269|PubMed:22354997}. Note=Recruitment to chromatin is not dependent on a functional PRC2 complex and H3K27me3 histone modification. {ECO:0000269|PubMed:22354997}.
Interaction partners:
- E3 ubiquitin-protein ligase RING1
- Polycomb group protein Psc
- Histone-lysine N-methyltransferase E
- Histone deacetylase HDAC1
- Polyhomeotic-proximal chromatin protein
- Histone H3.3A
- Polycomb protein esc
- Histone H3
- Polyhomeotic distal, isoform A
- Polycomb group protein Asx
Sequence:
MTGRGKGSKGKLGRDNATDDPVDLVYAAEKIIQKRVKKGVVEYRVKWKGWNQRYNTWEPEVNILDRRLIDIYEQTNKSSGTPSKRGIKKKEKEPDPEPESEEDEYTFTENDVDTHQATTSSATHDKESKKEKKHHHHHHHHHHIKSERNSGRRSESPLTHHHHHHHHESKRQRIDHSSSSNSSFTHNSFVPEPDSNSSSSEDQPLIGTKRKAEVLKESGKIGVTIKTSPDGPTIKPQPTQQVTPSQQQPFQDQQQAEKIASEAATQLKSEQQATPLATEAINTTPAESGAEEEEVANEEGNQQAPQVPSENNNIPKPCNNLAINQKQPLTPLSPRALPPRFWLPAKCNISNRVVITDVTVNLETVTIRECKTERGFFRERDMKGDSSPVA
Protein: CAP-Gly domain containing linker protein family member 4 (B5MCH3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVSMFRITGMLVLLFHATTQEPSAAMKLAKSNCVFFRDSF
Protein: AT24439p (Q8T3Z8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVPCNRDPKAVGRPRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAKSLVETFCDTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQIEGFSSENCGDLSFDVKGLATDTMIMMKSAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQLVNITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLLGAGVVETHNLSDTSDDDVSAPVKLPAVGGTPMRNLPINSNPLQMQPIRSPPKLPHVVELQMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSNAGSSSGSRSRSSSSSSSSSNNSSESNDSSDVEVVPNVPEGQLRA
Protein: HTH-type transcriptional repressor NemR (Bleach-sensing transcription factor) (Redox-regulated transcription factor NemR) (P67430)
Organism: Escherichia coli (strain K12)
Function: Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA. Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS. Involved in response to methylglyoxal.
Interaction partners:
- N-ethylmaleimide reductase
- Lactoylglutathione lyase
- HTH-type transcriptional regulator YjiE
- RCS-specific HTH-type transcriptional activator RclR
Sequence:
MNKHTEHDTREHLLATGEQLCLQRGFTGMGLSELLKTAEVPKGSFYHYFRSKEAFGVAMLERHYAAYHQRLTELLQSGEGNYRDRILAYYQQTLNQFCQHGTISGCLTVKLSAEVCDLSEDMRSAMDKGARGVIALLSQALENGRENHCLTFCGEPLQQAQVLYALWLGANLQAKISRSFEPLENALAHVKNIIATPAV
Protein: U3 small nucleolar RNA-associated protein 14 homolog C (Q5TAP6)
Organism: Homo sapiens (Human)
Function: Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Nucleolar protein 14
- Something about silencing protein 10
- U3 small nucleolar ribonucleoprotein protein MPP10
- Nucleolar protein 10
- U3 small nucleolar RNA-associated protein 18 homolog
- WD repeat-containing protein 3
- WD repeat-containing protein 46
- WD repeat-containing protein 36
- U3 small nucleolar RNA-associated protein 4 homolog
- U3 small nucleolar RNA-associated protein 6 homolog
Sequence:
MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKDKNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL
Protein: LIM domain 7 (A0A0G2K8R3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Emerin
- Alpha-actinin-4
- Alpha-actinin-1
- COMM domain-containing protein 6
Sequence:
MEGMEDAEADCSVAFAEAQRWVEAVTEKNFETRDFRASLENGVLLCDLINKLKPGVVRKINRLSTPIAGLDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRLKNVLITLYWLGRKAQNNPYYHGPYLNLKAFETLLGQALTKALEDSSCLKRSGRDSGYGDIWCPDRGDFPAPPGSHRREDSFESLDSLGSRSLTSCSSDLTLRGGREGCESDNDWEFTFKMQDYNKDDMSYRRISAIEPKSALPFNRFLPNKSKQPSYVPAPLRKKRPDKNEDNRRSWASPVYTETEGTFSSTQRRAWGPKMENWHTVQETSTSSWCLEEEEEKVTRLPNVVKDDLYVRKLSPVMPSPGSSFDQFLPKGWTPEDMNWKKIKRETYKPWYKEFQGLSQFLLLQALQTYSDDILSSETNVKLDPTSGPRLITRRKNFSPTPGYRAHDLEPQSLDPDLENDDFFVRKTRAFHANPCVLRAFEDFRRFSEPDDAVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPDRYQPVPFPEPWTLPPEIQAKFLSVLERTCPPKDKPSSCRVLVPSHRLKKDDMLTRKIQSWKLGTAVPPISFRPGPCSEADLRKWEAIREASRLRHRKRLMVERLFQKIYGENGSKSLSDVSAEDVQSLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSDRSSKTFREMLQDRESQSSTTTSRRRIYSSDDILDDGVLPPTVTLSETSYQSERLEDKARAHPAEMPKEDSTTFASREDGIAAEIPLASHIPEERRQAPWPSAETRQASSSSAESHQASLPSTESDQARLPSAEPHQASFSSAEPRQVPLVSAEPHQASSFSSTEPHQASLSSALQRPSSLSSSQQSWSTRGESTRISASLPRSYQRSDTARLTSVVTARPFGTSSRGISSLPRSYTMDDGWKYNGDVEVVKREQHDSGRAAGMKPDSSHFILGSSSEKEVATGEDVASLSSFVLPSSSSLSHDQAASSKATFSSTSGLDSVSDSGEGRSSSLREVSRSPDQFSDMRISINQTPGTKHDFGFTIKWDVSGISVASVEKGSPAEFSQLQVDDEILAINNTKFSYKDTKKWEEAMANAQETGNLVMDVRRYGKSGSPETKWIDTTSGIYSTEKSSSLSVTTDFSESLQSPYSESKEINGIHEESNAFDSKGKDHSEIASLPVPTLSAPSRWAWDQEEERRRQERWQKEQDRLLQEKYQREQEKLREEWQRAQQEAERENSKYLDEELMVLNSNSISLTSRESVTASWEPSWSEGSKSLDREGTRAGDEDRGQLEDDAVYEDQSQKLQERLMLEHEKKRKEQEAQEEELRKQREAEAQARAEAEAQARAEAQARAEAQAQAEAEARKRAEAQKLQAERERETSVKIYQYRRPIDSYDLPKREEESSGLLPIDRSKSRSTTELNDPLIEKSGSSKYSDRIGTTSFSQRSSKKDQGPSEAELERQQILQEMRKKTSLHNDNSWIRQRSASVNKEPICLTGIMRRGESLDNLDSQRPGSWRQSSWHSQPAGVYASSSVQDFSRLPPQLLSTSNRAYMRNPSSAVPPLAGSVKTSPGSPSPRSHSPSMSQSGSQLRNRSVSGKRVCSYCNSILGKGAAMIIETLGLCYHLHCFKCVSCERDLGGSSSGAEVRIRNHQLYCNDCYLRFKCFIPIVSLYPSLMIRT
Protein: Transmembrane protein (Q9FHB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSGGVGPTYNDITLPKEEEEEHQTQSTSTVSSTGKPAGFFSFRQLNILAIIIVLSASGLVTIQDFIFTILTLIYFFFLSKLIFPPHNNPNRDAPLTSSTNKIFRIYVTAAGIVGLIIPICYIFEGIVEDDKNGVSAAAPHVFLLASQIFMEGLATMFGFSAPARILVPIVYNARRVLTLVEWIMSEFSREDVTGTVSARRMYAGKVLAAANLGIWSFNLFGVLIPVYLPRAFKRYYGSDKED
Protein: Miranda (O44224)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFSKAKLKRFNDVDVAICGSPAASNSSAGSAGSATPTASSAAAAPPTVQPERKEQIEKFFKDAVRFASSSKEAKEFAIPKEDKKSKGLRLFRTPSLPQRLRFRPTPSHTDTATGSGSGASTAASTPLHSAATTPVKEAKSASRLKGKEALQYEIRHKNELIESQLSQLDVLRRHVDQLKEAEAKLREEHELATSKTDRLIEALTSENLSHKALNEQMGQEHADLLERLAAMEQQLQQQHDEHERQVEALVAESEALRLANELLQTANEDRQKVEEQLQAQLSALQADVAQAREHCSLEQAKTAENIELVENLQKTNASLLADVVQLKQQIEQDALSYGQEAKSCQAELECLKVERNTLKNDLANKCTLIRSLQDELLDKNCEIDAHCDTIRQLCREQARHTEQQQAVAKVQQQVESDLESAVEREKSYWRAELDKRQKLAENELIKIELEKQDVMVLLETTNDMLRMRDEKLQKCEEQLRNGIDYYIQLSDALQQQLVQLKQDMAKTITEKYNYQLTLTNTRATVNILMERLKKSDADVEQYRAELESVQLAKGALEQSYLVLQADAEQLRQQLTESQDALNALRSSSQTLQSEVSLKESLLHELLAGEAETLAKFNQIANSFQERIDGDAQLAHYHELRRKDETREAYMVDMKKALDEFATVLQFAQLELDNKEQMLVKVREECEQLKLENIALKSKQPGSASLLGTPGKANRSNTTDLEKIEDLLCDSELRSDCEKITTWLLNSSDKCVRQDTTSEINELLSAGKSSPRPAPRTPKAAPHTPRSPRTPHTPRTPRSAASTPKKTVLFAGKENVPSPPQKQVLKARNI
Protein: Ethylene-responsive transcription factor ERF094 (Protein OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF 59) (Q9LND1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Acts as an essential integrator of the JA and ethylene signal transduction pathways. Activates the expression of the PDF1.2A gene.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Defensin-like protein 16
- Mediator of RNA polymerase II transcription subunit 25
- Transcription factor MYC2
- Vegetative storage protein 2
- Protein ETHYLENE INSENSITIVE 3
- Putative defensin-like protein 15
- Glutaredoxin-C9
- Coronatine-insensitive protein 1
- Transcription factor TGA5
- Vegetative storage protein 1
Sequence:
MEYQTNFLSGEFSPENSSSSSWSSQESFLWEESFLHQSFDQSFLLSSPTDNYCDDFFAFESSIIKEEGKEATVAAEEEEKSYRGVRKRPWGKFAAEIRDSTRKGIRVWLGTFDTAEAAALAYDQAAFALKGSLAVLNFPADVVEESLRKMENVNLNDGESPVIALKRKHSMRNRPRGKKKSSSSSTLTSSPSSSSSYSSSSSSSSLSSRSRKQSVVMTQESNTTLVVLEDLGAEYLEELMRSCS
Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (A0A3B3IS57)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL