wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein C11orf87 (Q6NUJ2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSARAPKELRLALPPCLLNRTFASPNASGSGNTGARGPGAVGSGTCITQVGQQLFQSFSSTLVLIVLVTLIFCLIVLSLSTFHIHKRRMKKRKMQRAQEEYERDHCSGSRGGGGLPRPGRQAPTHAKETRLERQPRDSPFCAPSNASSLSSSSPGLPCQGPCAPPPPPPASSPQGAHAASSCLDTAGEGLLQTVVLS
Protein: Uncharacterized protein, isoform A (Q9VLQ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGGNVEQRPWTPTVRIGKIAAETTNPGPATVQLPTLIGSKVPDSKKKAAPSYSFGHKLGGKYDTSGPGPAQYNVTGMRAKGRDYPRAATLQSRPKELTRFSNPGPGEYDVVPAAKAVIDATPKYTFGQRPVALKTFQIPAPNVYKIPTVMGSSKEGKIRSAPAYTITGREKPPLIPVMIFPGPGYYDGEYTVVKPKPPVFSMRGKYKMGSEDSKPGPGAHCPEKYWEKRSPPAISFGILHSPYIKKPLPVNVPQRCVRSLLENRADKPYDNI
Protein: Fibroblast growth factor (FGF) (F7FG05)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFSKHHLMPLLVTTKMGSLCRARNQSMAFWRWKKKEPAESTQTDRNARQSCFRLGVHIATGRRDDDQDTEAHLEIREDGTVVGTAHRSPESLLELKALKPGVIQILGVKASRFLCQQPDGTLYGSPHFDPEACSFRELLLKDGYNVYQSEAHGLPLRLPQKDSQDPATRGPVRFLPMPGLPHEPQEQPGVLPPEPPDVGSSDPLSMVEPLQGRSPSYAS
Protein: Leptin (Obesity factor) (H9NAC2)
Organism: Salvelinus alpinus (Arctic char) (Salmo alpinus)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDCSMALLLSSLLALFSVGAGASLSLHVVRTKVKDLAQTMVIRIKKLDISPNLIEGMDPFLPAAAVDQHIESLPSIVETMGFYQDLLLFLDWADLKQLVEDTSTMRGLLENWMISRCPGHQQKQTGEGGLSEALKDTTRKYGLSVGPVALNRLKGYLGRLLLNLDQLNYCY
Protein: Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) (Q80YX1)
Organism: Mus musculus (Mouse)
Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Integrin alpha-9
- Syndecan-4
- Integrin alpha-8
- Integrin beta-1
- Integrin alpha-V
- Integrin beta-3
- Syndecan-3
- Syndecan-1
- Integrin beta-6
- Aggrecan core protein
Sequence:
MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDSLTFFWTTPLAKFDRYRLNYSLPTGQSMEVQLPKDATSHVLTDLEPGQEYTVLLIAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGYRTPVLSAETSTGTTPNLGEVTVAEVGWDALTLNWTAPEGAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQDFGTAPLSVEVLTEDLPQLGGLSVTEVSWDGLTLNWTTDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGYRTPMLSTDVSTAREPEIGNLNVSDVTPKSFNLSWTATDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTEALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKPLRAETITEAEPEVDNLLVSDATPDGFRLSWTADEGIFDSFVIRIRDTKKQSEPQEISLPSPERTRDITGLREATEYEIELYGISRGRRSQPVSAIATTAMGSPKEIMFSDITENAATVSWRAPTAQVESFRITYVPMTGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFEESDPVSGTLITALDGPSGLLIANITDSEALAMWQPAIATVDSYVISYTGERVPEVTRTVSGNTVEYELHDLEPATEYILSIFAEKGQQKSSTIATKFTTDLDSPREFTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSARIQALSGSLRSKLIQTIFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRRKRA
Protein: Polyribonucleotide nucleotidyltransferase 2, mitochondrial (AtmtPNPase) (EC 2.7.7.8) (Polynucleotide phosphorylase 2) (PNPase 2) (Q9S7G6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the 3'-end maturation of mitochondrial mRNAs, rRNAs and tRNAs. Functions as a poly(A) mRNA 3'-5' degrading phosphorylase and is required for the degradation of highly expressed transcripts of non-coding regions.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15037609}.
Interaction partners:
- Ribonuclease II, chloroplastic/mitochondrial
- Polyribonucleotide nucleotidyltransferase 1, chloroplastic
- Pentatricopeptide repeat-containing protein At1g18485
- Poly
- U4/U6 small nuclear ribonucleoprotein PRP4-like protein
Sequence:
MSSIVNRASSASLPNFLAWRALGFRTICSGRLGFAPSVPDSPVSAGTKILESFKEEFEVGSRVVSFETGKIARFANGSVVLGMDETKVLSTVTCAKTDSPRDFLPLTVDYQEKQYAQGLIPNTYMRREGAPKERELLCGRLIDRPIRPLFPTGFYHEVQIMASVLSSDGKQDPDILAANASSAALMLSDVPWGGPIGVIRIGRICGQFVVNPTMDELSSSDLNLIYACTRDKTMMIDVQSREISEKDLAAALRLAHPEAVKYLDPQIRLAEKAGKQKKEYKLSMLSDKTLEKVADLAATRIESVFTDPSYGKFERGEALDNIGKDVRKVFEEEGDQESLSILPKAVDTVRKKVVRSRMISDGFRVDGRHVDEVRPIYCESHYLPALHGSALFSRGDTQVLCTVTLGAPAEAQSLDSLVGPPKKRFMLHYSFPPYCTNEVGKRGGLNRREVGHGTLAEKALLAVLPPEEAFPYTIRINSEVMSSDGSTSMASVCGGSMALMDAGIPLRAHVAGVSVGLITDVDPSSGEIKDYRIVTDILGLEDHLGDMDFKIAGTRDGVTAIQLDIKPAGIPLDIVCESLENAREARLQILDHMERNINSPRGQDGAYSPRLATLKYSNDSLRTLIGPMGVLKRKIEVETGARLSIDNGTLTIVAKNQDVMEKAQEQVDFIIGRELVVGGVYKGTVSSIKEYGAFVEFPGGQQGLLHMSELSHEPVSKVSDVLDIGQCITTMCIETDVRGNIKLSRKALLPKPKRKPASDAGKDPVMKESSTVYIENSSVGEIVASMPSIVTPLQKSRLSVPAVVIRTAVECNEAEKSSPVNDNDKPRRAATSKPDRKPKSTASKLIATQKEEEALESIAPEETSAECGEILKQDGKLKSVSPKNNSTASNLVSFSKAKKSTMKENLSENKAEESASVSTRKLKIGTEMTATVDHVRALGLVLDLGGEIRGMYIFQGDKDKFKKGDTLRVKCTSFNTKGVPVMALVDEEGEE
Protein: Actin binding Rho activating protein b (Zgc:92005) (Q68EG8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSARKPSANKNIKKLRTISMVCSLTRSWQQWVSENEDKQSSEPSGWAPCYAGDPKDDKKEAAKIKLSQKALQTTTSENKDNGEPAGESRIKTTPVVKTVTRDVQERSAGIDFLTKRICKDPETDELDNMLSKKGSPTRRRKCSNMVSELTRGWKEMEKEKKQDHGDNEDTGTNREESENNRSNEHTESAVAIKRSSVPGGKKDIEDANKINNLSKKYSTVGNLKSRWQNWASEHTINQKLNPFSEDFDYEYSMSTRLHKGEEGYGRPKEGSKTAERAKRAEKHIHREIDDMCFVIRTMADPDPDGYTRVTFGELFDRYVRISDKVVGILMRARKHGKVAFEGEMLWQGQDDDVIITLLI
Protein: NEK6-subfamily protein kinase (EC 2.7.11.34) (Q5TBH2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH
Protein: Probable methyltransferase PMT8 (EC 2.1.1.-) (Q940J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- AP-1 complex subunit gamma-2
Sequence:
MMRGRSDGGLKKRLIASVCVVALFVCFLFMYYGSSSQGASALEYGRSLRKLGSSYLSGDDDNGDTKQDDSVANAEDSLVVAKSFPVCDDRHSEIIPCLDRNFIYQMRLKLDLSLMEHYERHCPPPERRFNCLIPPPSGYKVPIKWPKSRDEVWKANIPHTHLAKEKSDQNWMVEKGEKISFPGGGTHFHYGADKYIASIANMLNFSNDVLNDEGRLRTVLDVGCGVASFGAYLLASDIMTMSLAPNDVHQNQIQFALERGIPAYLGVLGTKRLPYPSRSFEFAHCSRCRIDWLQRDGLLLLELDRVLRPGGYFAYSSPEAYAQDEENLKIWKEMSALVERMCWRIAVKRNQTVVWQKPLSNDCYLEREPGTQPPLCRSDADPDAVAGVSMEACITPYSKHDHKTKGSGLAPWPARLTSSPPRLADFGYSTDMFEKDTELWKQQVDSYWNLMSSKVKSNTVRNIMDMKAHMGSFAAALKDKDVWVMNVVSPDGPNTLKLIYDRGLIGTNHNWCEAFSTYPRTYDLLHAWSIFSDIKSKGCSAEDLLIEMDRILRPTGFVIIRDKQSVVESIKKYLQALHWETVASEKVNTSSELDQDSEDGENNVVFIVQKKLWLTSESLRDSE
Protein: NAD kinase (EC 2.7.1.23) (ATP-dependent NAD kinase) (P0A7B3)
Organism: Escherichia coli (strain K12)
Function: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates (UTP, CTP, GTP, dATP, TTP) as phosphoryl donors, while nucleoside mono- or diphosphates and poly(P) cannot.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00361}.
Interaction partners:
- Nicotinate-nucleotide adenylyltransferase
- NH
- Soluble pyridine nucleotide transhydrogenase
- Trifunctional NAD biosynthesis/regulator protein NadR
- NAD-dependent protein deacylase
- NAD
- DNA repair protein RecN
- NAD
- NAD-capped RNA hydrolase NudC
- Nucleoside triphosphate pyrophosphohydrolase
Sequence:
MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCTKGYEVIVEQQIAHELQLKNVKTGTLAEIGQLADLAVVVGGDGNMLGAARTLARYDIKVIGINRGNLGFLTDLDPDNAQQQLADVLEGHYISEKRFLLEAQVCQQDCQKRISTAINEVVLHPGKVAHMIEFEVYIDEIFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRNDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYFNTLSTKLGWSKKLF
Protein: FG-GAP repeat-containing protein (Q553M8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MRKRDTWLLLVSILVVFISLYRQKDYKLNLLLEIPIDTNNYENSHYPKINEFLPLPIITDLNGDGFNEIIYVTNDFKIRILDTVTPNNIEKFRFGVNVNENENENENDNDQNSLLELPVLYESSLLSDVGLATGRRPIAIKTGYAKHSIPGERRQQIIVVVTDGWAVLCFDNKLKKLWESYASDEVLPGHYQSEISITILPTTIPDDKGIVIIGGRMEPLPGVIHKPHYSIPMFGEKVETDKDHDHKRDDDHDSFTAHREENHFSYFSYDCKDGYKRWSHEENDFKPENPHTTEEHKKDSDISLHSFKQHIFSQLEHLGEVDWKTYRDSILASLPHKWSSNFDTKLEPRHFEKKINTIRGTTNNDGTNVINGLIGSSNTLNNEMIEFYSKNFDTFSILSKKDQISFKSQHIENPNVIVTHHKYGIEVIHIVSGKTLCKLVLDGTDFYTDSNRYIVYLDLNGDGVLDQVRSYAGNFKNSQLGRNKKNKNIGDDNNEDSYCVGLALSGLPPKETLFDLKICGGQIFNMDYYLWKDSNLNKRNTEHEGVGLGDDTEGEEEEEEQDAGILEENKMKQKQQKQQKPKKKKMADDKLLKNQKSSSTMSKSEKEIQTVPPVFFRSSNSDRLSTLFMVNTGLISCFDTASFGGKKIWRVDTGIHWSKHLEPRTFPSLQVFSFDIQSTQPFILAIGEQSMVILNENGEILVDQQIWNAGESDPITAPPVVADFNNDGINDFLITTLSGYHIFVTEKGTYSTLLPMIGLVLIGMLLLLLLLSGETGKKVLTKKLQNNYHYLRKSKKSTD
Protein: TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) (Q12933)
Organism: Homo sapiens (Human)
Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:19150425}.
Interaction partners:
- Tumor necrosis factor
- Mitochondrial antiviral-signaling protein
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Receptor-interacting serine/threonine-protein kinase 1
- TNF receptor-associated factor 1
- Baculoviral IAP repeat-containing protein 2
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Tumor necrosis factor receptor superfamily member 1A
- NF-kappa-B essential modulator
- FAS-associated death domain protein
Sequence:
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
Protein: Uncharacterized protein (Q583W5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMNPEDVLQSIANVCRTGHLGDAAAAGIKAYIAAPFKHSNTSHSSTTVTNSSTMANIPPANVTAAPPTGLGGVGGGFTTSIQQQPFALLNTVKDTQASHVTATDELDEQVSKIKSLMNLLLLCGDPERFGSVTCVIASIAPTVSSNVVNFIKTEISPTSLSLIDHGPVASSLASNGKSNPVLLAAQCLFLLTRHFQMNPDVVRGICELLEILLQEMSCHTNSSTTSAASFRQHPSTRGLCALTWFVTMSLVNTLAVWQKLRGATGVAQENALLGSNIVADIEKWATNLHARLERTQDTGFLSSSLQMRRGISQQYQHDEAAWRGGNGKRPRWLVIVDGYMSIVLLALGMFLCGKGDERGLDKAVEAFVGDCAHSTGAGRRGKVMKYIVDLAPLQAMLAIPLECIYIIPYEMAAYMFDEMLVAVKHVADIDVSSCVRYLEALQSKSDASYAIKGDVAAADGGLQRPEANKAQAGEEPFISETAHILRALTICLENLPSTVLNPDIDVDCAVTFFIFKNCVTHMRAIFETQRSSGAWEAYTLKVVTRFLDVLAMIGRNPQYTQRVVALFSEMQVNCAELQWSSLIAKAQACAGASGDAVPLTLCDNGGSMAALRKPSVSGAAAPGRHRQFTPEYLQEKQQEFASSVFVLLRQMATHPLLSEQVRQHTTLNVVLGFLHATKLSQLVLGRVLSLIGSLITNHEEAACVWTYLEESHLICSTENAAAQTKGGQGSSTVMGNKQRQGDNVAVTVEARSLLGHCQYECHHATYSITIGFLDLMLAMFKYHRPDVTCLPTYATIIRFISEEIFRGVSRRSFSCEKERYIVTALAAVVLNRALSLHLPLHGKNNVPSFQLVMACSKAPADVLGELLHIIGEAAGALHEMDNYQRAAVRQCLALLRTAITVKEEQRLDNIFTFDARTHSSKEFAAQLLPLCVSFDSLLANKALQVLLLLPHSTLSEAARYWDGRPDALETVITPYVSTLREEAVSNPVIHAPPALAVLDSDEVQLLMPYVETETKSLMLDLLIQHAAAPQPSITSWLCGYQMYGSTEELLPGYCLEPIIDGARSRVLEEKSPHIAVKYVKLLYQLRANPSLCTPSLKRLMRERGTDEMFHVLKTLRPDQCPPLVMSKYAFVMKLLGLELFSVGTEFLEELNALSPLTPHASVVELLFQLLQAAPPHELYRQTSESGAQLVLEDHNNGVALDFAQWPSSCLMSLPPFPANCVAPGGAESYVFRASDDVPQYSIPRLYEALRRENIANKGEAPSGAELREQLGVFARANECLLAYASAVQFLDGWCTLTNITVVVLDRISHERVVYLARSMLGSVQLISNLTVAAQEQIVHRVSRTMSTLAAQLRRKLGRNTNGEGLSGATATCAGDEGPVEADVSVPQTAQQDVTSFLQVTGTKISAFGTNASLTRGRLTGGSKRDPRGAVVSRMDATGVISTLVEAPSRAAIHSENLQLLRTLLIVTVQWGSRVPQARQHLYDAISAFLSISGTNVDDITLQQYHNALFDILVQDTSATATNGNKFAALPLLSQLMYISPQLCELLCVSLTNDGVSPRLMSCVAQCFQAIDESICAFFSHGGASVSSILWFVRVVFDMLMVISQRHSLQLFHANALTHCMGMKLWSTCARIMLGHVKYAAGTSLSNTENIEVFKEVIHNVLLSTIRWFNAVLSALDNSESALGAVADFVFSQQLLFQSVLVSPTTSEHRRFIDTPTLEMYGEIGGLLLRLASSPLVDECRPFVQLFALTELLDVLTRSEFINTPIFLEDRMPNSVAAVPLSSSQSGSLPSIYQRQLIAVATQNIVLFIFFVERLVQHFNGYEGNVPSAQQQPELQKKSYLRDDPRSRFLITTITENVVAIMEKFCDGQVLHVATVVPYFVATHSLVLLLHAFLLVDRAFSLNNVNSNNQWGGIVHALEEARRVVGLWRALHSDYHKGVKVSRTGGRWSVAAPSLSNQTLHHAAVMPVPPAEVESPSAAGSRAAAGEMIHADNAAPAPAENGTNMASITSGTVCDRTTIGALVELSRIGCMDTVSDEPPVYKAVDQVVLMESFLRRVKVAISNALREASRM
Protein: Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (O35344)
Organism: Mus musculus (Mouse)
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O00505}. Nucleus {ECO:0000250|UniProtKB:O00505}.
Interaction partners:
- Importin subunit alpha-3
- Exportin-2
- Importin subunit beta-1
- Importin subunit alpha-5
- Nuclear factor NF-kappa-B p105 subunit
- Transcription factor p65
- Regulator of chromosome condensation
- Importin subunit alpha-7
- Importin subunit alpha-1
- GTP-binding nuclear protein Ran
Sequence:
MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTANLQTKEFNF
Protein: Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) (A0A140VJU5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004450}.
Interaction partners:
Sequence:
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
Protein: Centrin-1 (Caltractin) (P41209)
Organism: Mus musculus (Mouse)
Function: Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium {ECO:0000269|PubMed:30120214}. Note=Centrosome of interphase and mitotic cells. In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (PubMed:30120214). {ECO:0000269|PubMed:30120214}.
Interaction partners:
- Pericentrin
- Protein SFI1 homolog
- DNA repair protein complementing XP-C cells homolog
- MORN repeat containing 1
- Centrosomal protein POC5
- Centrosomal protein of 135 kDa
- Centrosomal protein of 164 kDa
- Ninein
Sequence:
MASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDGSGTIDVKELKVAMRALGFEPRKEEMKKMISEVDKEATGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEEEFLKIMKKTNLY
Protein: Sugar transport protein 14 (Hexose transporter 14) (Q8GW61)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates an active uptake of hexoses, probably by sugar/hydrogen symport.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- UDP-galactose/UDP-glucose transporter 5B
- Sucrose transport protein SUC4
- Glycoside hydrolase family 28 protein
Sequence:
MAGGALTDEGGLKRAHLYEHRITSYFIFACIVGSMGGSLFGYDLGVSGGVTSMDDFLKEFFPGIYKRKQMHLNETDYCKYDNQILTLFTSSLYFAGLISTFGASYVTRIYGRRGSILVGSVSFFLGGVINAAAKNILMLILGRIFLGIGIGFGNQAVPLYLSEMAPAKIRGTVNQLFQLTTCIGILVANLINYKTEQIHPWGWRLSLGLATVPAILMFLGGLVLPETPNSLVEQGKLEKAKAVLIKVRGTNNIEAEFQDLVEASDAARAVKNPFRNLLARRNRPQLVIGAIGLPAFQQLTGMNSILFYAPVMFQSLGFGGSASLISSTITNAALVVAAIMSMYSADKFGRRFLLLEASVEMFCYMVVVGVTLALKFGEGKELPKSLGLILVVLICLFVLAYGRSWGPMGWLVPSELFPLETRSAGQSVVVCVNLFFTALIAQCFLVSLCHLKYGIFLLFAGLILGMGSFVYFLLPETKQVPIEEVYLLWRQHWLWKKYVEDVDE
Protein: Uncharacterized protein (Q57W28)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLYKDLLHPLSLSWLAYDVLCVVVRSFSPETLVRKRPKRGSKAKERRHRRDHSLLESRDYRSRHNSSGDHESTDPSPRFTSHNTSLQANASAGSERPPTVPSRAAAGSGSSRPPSRAGSRLNSRSSSRSGSRHHTEVPLNEGPPQSFFGRLRNWRTINVREPVLLLTHVLRAMPVAVLHCFTQLRTDVATLGLLRFSDLSDTAAALLVFNEDAVFAPDFVWNFTITRCLLGAMQQYVLGRVCLETNFVVNRLRSRRAYRHIIGWAMRLLTRLLTDPISCSILSPMLLCTVKDFSPVTGPLRYTPSGLCAAALTGFVGVVLEQLVLPTAAICCQRVVVHIYDGLDYVLTRRYATKNIMRDEAVDSRVNASGIDSATASEDDRESGQRTARKDAESAKRHSHNREDAQQVGKGAQMAVFRAIICRVVGALLAQCAVQHPLTVLSRLLYARAVLHGTGLLKSYADFPAKHLVWADFAAFLKQNAHGSSSGVPALEALRGIGCFVGCEVSLIRSSILRCSAQERAIEELLLQAERRRQGGADSAGMSFTSSVSHASALESMELMTRCIASTSPLFNMVHLTSFTKLLSFYMDMWVRLRGE
Protein: Phosphoprotein p30 (Q8V1E7)
Organism: African swine fever virus (ASFV)
Interaction partners:
Sequence:
MDFILNISMKMEVIFKTDLRSSSQVVFHAGSLYNWFSVEIINSGRIVTTAIKTLLSTVKYDIVKSAHIYAGQGYTEHQAQEEWNMILHVLFEEETESSASSESIHEKNDNETNECTSSFETLFEQEPSSEEPKDSKLYMLAQKTVQHIEQYGKAPDFNKVIRAHNFIQTIHGTPLKEEEKEVVRLMVIKLLKKNKLLSHLHLMF
Protein: Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt) (Q9VJC7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03135}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- FI01658p
- GM03767p
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein bS16m
- DSec61alpha
Sequence:
MLLQRFFTRALHSTRQLYAGSGGSGGLEKSALAALRKKTGYTFANCKKALEKHNNDVGLAEKWLHEQAQTLGWSKATKVADRATAHGLIGVLIRGNRGAMVELNCETDFVARNDTFKRFVDHVACMCLQYTDLTDFDGDLWKLGFDADALRNLRTEEGRTLGDHLALLIGAIGENATIRRALCFKANNDLKLVGYAHPAPTNVGTTEGITQVGKYGAIVAYRSTHPLLDFEFHKSICQQIVGMKPTKIGEYDKDKPAENKDDETCLIHQEYLLDADKTVGEALQEHNCEIVDYHRFECGEHTERSLEAIIRSQHQSSN
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB2 (TFIIH subunit XPB) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB2) (ERCC3 homolog 2) (RAD25 homolog 2) (AtXPB2) (XPB homolog 2) (Q9FUG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit TFB4
- General transcription and DNA repair factor IIH subunit TFB2
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 2
- Cyclin-H1-1
- General transcription and DNA repair factor IIH subunit TFB1-3
- General transcription and DNA repair factor IIH subunit TFB1-1
- General transcription and DNA repair factor IIH subunit TFB5
- Pentatricopeptide repeat-containing protein At4g30825
- General transcription and DNA repair factor IIH subunit TFB5
Sequence:
MGNDERKRPTKKMKYGGKDDQKMKNIQNVEDYYDDADEDSRDGEGEEKRRDFTDLELKPDHGNRPLWACADGKIFLETFSPLYKQAYDFLIAIAEPVCRPESMHEYNLTPHSLYAAVSVGLETETIISVLNKLSKTKLPGEIIDFIHASTANYGKVKLVLKKNRYFIESPFPEVLKRLLSDDVINRARFTSEPYYGGDGFTIGKTSGELEAGPGELLNEAELAAAAEEKETHSFEIDPALVENVKQRCLPNALNYPMLEEYDFRNDNVNPDLDMELKPHAQPRPYQEKSLSKMFGNGRARSGIIVLPCGAGKSLVGVSAAARIKKSCLCLATNAVSVDQWAYQFKLWSTIKDDQICRFTSDSKERFRGNAGVVVTTYNMIAFGGKRSEEAEKIIEEMRNREWGLLLMDEVHVVPAHMFRKVISITKSHCKLGLTATLVREDEKITDLNFLIGPKLYEANWLDLVKGGFIANVQCAEVWCPMTKEFFAEYLKKENSKKKQALYVMNPNKFRACEFLIRFHEQQRGDKIIVFADNLFALTEYAMKLRKPMIYGATSHIERTKILEAFKTSKTVNTVFLSKVGDNSIDIPEANVIIQISSHAGSRRQEAQRLGRILRAKGKLEDRMAGGKEEYNAFFYSLVSTDTQEMYYSTKRQQFLIDQGYSFKVITSLPPPDAGSSLGYHSQEEQLSLLGKVLNAGDDMVGLEQLEEDTDGKALKTRRSMGSMSAMSGANGRVYMEYNSGRQKSGNQSKKPKDPTKRHNIFKKRYV