wanglab/gogpt-training-data huggingface dataset:
Protein: Possible magnesium chelatase (P71552)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv0959
- Uncharacterized protein Rv2850c
- Coproporphyrin III ferrochelatase
- Coproporphyrinogen III oxidase
- Phosphoribosylglycinamide formyltransferase
- Bifunctional purine biosynthesis protein PurH
- UPF0353 protein Rv1481
Sequence:
MSPSNLPRTVGELRAAGHRERGVKQEIRENLLTALADGDNVWPGILGFDDTVIPQVERALIAGHDFVLLGERGQGKTRLLRALAGLLDEWTPVIAGAELGEHPYTPITPESIRRAAQLGDDLPVAWKHRSERYTEKLATPDTSVADLVGDVDPIKVAEGRSLGDPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLDVLVVASANPEDYTNRGRIITPIKDRFGAEIRTHYPLELEAEMGVIVQEAHLSAQVSDYLMQVLARFARYLRESRSIDQRSGVSARFAIAAAETVAAAARHRGAVLGETDPVARVVDLGTVIDVLRGKLEFESGEEGREQAVLEHLLRRATADTASRVLGGIDVGSLVTAVEGGSAVTTGERVSAKDVLAAVPGLPVVDRIARKLGAESEGERAAALELALEALYLAKRVDKVCGEGQTVYG
Protein: Uncharacterized protein C14G10.01 (O74414)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10759889}.
Interaction partners:
- L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
- Threonylcarbamoyl-AMP synthase
- Putative holo-[acyl-carrier-protein] synthase
- Probable thymidylate synthase
- Uncharacterized protein C1F12.08
- Triosephosphate isomerase
- Uncharacterized protein C4B3.18
- Probable citrate synthase, mitochondrial
Sequence:
MLILGLTGSIATGKSTVSREFQEKYHIKIIDADVLARKVVEPNTPCLIKIQKEFGNEVLHEDGTLNRAKLGQAVFQDAGKRSLLNSIIHPAVRLEMLKELLRCYVRGYSIVILDVPLLFEAKMQFICWKTICVSCDKSIQKQRLLARNPELTAEDAENRVQAQMPLELKCQLADIVIENNSDLETLYENIHNVLPLITPSYFFTLLCLILPPLQITLQVIAFVSQKKKVSEFRKHI
Protein: Forkhead box P3 (A0A8I6G4G9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MPNPRPAKPMAPSLAPGPSPGGLPSWKTAPKGSELLGTRGPGGPFQGRDLRSGAHTSSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHGHTPVLQVRPLDNPAMIGLPPPTAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKAFEEPGEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQASVDKSSCCLVATSTQGSVLPAWSSPREASDSLFAVRRHLWGSHGNSTFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPSKCSNPCP
Protein: Sodium/hydrogen exchanger (M9NDU7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSIRTEQDYDSATPALAQQMNLARRACWRIKSYSSESLFKTYASVITDTSANEIDAEAPPPPRDKTKTRIEPQIAPAKRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNAEECQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRANNNSLIAHIQNLPGFDASKARIVVQHYAPKADDNPDTDIESPEQAIGPTAAELILPWRRDRSYQSIVAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKRQGDECTDAVQQNEFPAWASNKEYLAYNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSSQPPNAPSTSIHNPRLDKRSQSISSSSLGAGAHQLGPEGHSGPFPVTASHRRNVRRGSMLELSGLIATGRRPSRILQFSPGATNLLGSAMIPSPSPPPPTTSTTTTTTTTTTVKPTSTSTTKNNKTNNSTDTTSASATNSTPTSPNSEDSATYTYHTK
Protein: Ornithine carbamoyltransferase subunit I (OTCase-1) (EC 2.1.3.3) (P04391)
Organism: Escherichia coli (strain K12)
Function: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Argininosuccinate synthase
- N-acetyl-gamma-glutamyl-phosphate reductase
- Amino-acid acetyltransferase
- Carbamate kinase-like protein YqeA
- Acetylornithine deacetylase
- Carbamate kinase-like protein YahI
- Acetylglutamate kinase
- Carbamate kinase
- Ornithine carbamoyltransferase subunit F
- Argininosuccinate lyase
Sequence:
MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYASVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLVAPQACWPEAALVTECRALAQQNGGNITLTEDVAKGVEGADFIYTDVWVSMGEAKEKWAERIALLREYQVNSKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSK
Protein: Alpha-tectorin (O75443)
Organism: Homo sapiens (Human)
Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.
Interaction partners:
- Otoancorin
- Cell adhesion molecule CEACAM16
- Ubiquitin-like protein FUBI
- Cochlin
Sequence:
MNYSSFLRIWVSFIFALVQHQAQPRELMYPFWQNDTKTPKVDDGSSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFVAPFWADVHNGIRGEIYYRETMEPAILKRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDDLNCTVKCRCLDFNNEIYCQEASCSPYEVCEPKGKFFYCSAVETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRRGSAVSWVKELSVEVNGYKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGLLVTFDGQHYASISVPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCVDNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPDTCSDLTASRNCATPCTEGCECNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGDVYCFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPSEFSYTLLKTCPERPEYLEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQEVELPFFHPSGKLEIYRNKNSTTVESKGVVTVQYSDIGLLYIRLSTTYFNCTGGLCGFYNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCPLECPENSHFEECITCTETCETLTLGPICVDSCSEGCQCDEGYALLGSQCVTRSECGCNFEGHQLATNETFWVDLDCQIFCYCSGTDNRVHCETIPCKDDEYCMEEGGLYYCQARTDASCIVSGYGHYLTFDGFPFDFQTSCPLILCTTGSRPSSDSFPKFVVTAKNEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPDDDLEMPMGLLASSVNEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAAFSKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGITVTGWRNYTSCTVTCPPNSHYESCVSVCQPRCAAIRLKSDCSHYCVEGCHCDAGYVLNGKSCILPHSCGCYSDGKYYEPKQLFWNSDCTRRCRCFRRNVIQCDPRQCKSDEECALRNGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSAPNLTIISPVYFYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISISERLQNKVCGLCGNFNGDLTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLAPSCNELQFSQYAAMCDNVHIQKMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYSHKKFQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELGNGRELCGCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCTGIEGEDFISFQINNTKGNCGNIVQSNGTHIMYKNTLWIESANNTGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINLTVPTQEGSFITKMALYKNASYKHPYRQGEVVLTTRDVLYVGVFVVGADATHLILTLNKCYATPTRDSNDKLRYFIIEGGCQNLKDNTIGIEENAVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTKEPKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGTLQEDGKSCRASNSSMELQVWTLLLIMIQISLWHFVYKSGTTS
Protein: Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt)) (P46198)
Organism: Bos taurus (Bovine)
Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular location: Mitochondrion.
Interaction partners:
- Translation initiation factor IF-3, mitochondrial
- Large ribosomal subunit protein bL9m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein mL62
- 40S ribosomal protein S30
- Ubiquitin-like protein FUBI
- 40S ribosomal protein S30
- Large ribosomal subunit protein uL2m
- Small ribosomal subunit protein uS7m
Sequence:
MNRKILKLENLLRFHTICRQLHSLCQRRMLAQWRHMFSSAYAVHTAQLYTRPWQTDALLRAALSQRRLLVTKKEKRSQKSPLPSTKSKKEVEVWLGMTVEELARAMEKDIDCVYESLMNTAIDIDSLETHSRLDEVWIKEVIKKSGMKLKWSKLKQDKVRENKDAVKRPQADPALLIPRSPVVTIMGHVDHGKTTLLDKLRKTQVAAMEAGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVESIQHAKDAHVPIVLAINKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVHVSALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFTDKGRGPVTTAIIQRGTLRKGSILVAGKSWAKVRLMFDENGRAVNEAYPSMPVGIIGWRDLPSAGDEILEVESEPRAREVVDWRKYEQEQEKNKEDLKLIEEKRKEHQEAHRKDREKYGTVHWKERSYIKYREKRQQQPLKPKEKLERDSNVLPVIVKGDVDGSVEAILNVMDTYDASHECELDLVHFGVGDISENDVNLAETFHGVIYGFNVNAGNVIQQLAAKKGVKIKLHKIIYRLIEDLQEELSSRLPCIVEEHPIGEASILATFSITEGKKKVPVAGCRVQKGQIEKQKKFKLIRNGHVIWKGSLISLKHHKDDTSVVKTGMDCGLSLDEEKIEFKVGDAIICYEEKEVPAKTSWDPGF
Protein: Kazal-type serine protease inhibitor domain-containing protein 1 (Bone and odontoblast-expressed protein 1) (Insulin-like growth factor-binding-related protein 10) (IGFBP-rP10) (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (Q8BJ66)
Organism: Mus musculus (Mouse)
Function: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18757743}.
Interaction partners:
Sequence:
MPRVFTGLPANYAAPTLALSLLLPLLLVVWTQLPVSARPSTGPDYLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSANFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLTVLTPEQLNATGFSQLQSRSLFPEEEEEAESEELGDYY
Protein: Importin subunit alpha-8 (Karyopherin subunit alpha-7) (C0LLJ0)
Organism: Mus musculus (Mouse)
Function: Functions in nuclear protein import.
Subcellular location: Nucleus {ECO:0000269|PubMed:20699224}. Note=In MII-stage oocytes, localizes to the spindle.
Interaction partners:
- Importin subunit beta-1
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran, testis-specific isoform
- Exportin-5
- Importin subunit alpha-4
- Importin subunit alpha-5
- Importin subunit alpha-7
- Importin subunit alpha-3
- Ran-specific GTPase-activating protein
Sequence:
MATSKAPKERLKNYKYRGKEMSLPRQQRIASSLQLRKTRKDEQVLKRRNIDLFSSDMVSQALVKEVNFTLDDIIQAVNSSDPILHFRATRAAREMISQENTPPLNLIIEAGLIPKLVDFLKATPHPKLQFEAAWVLTNIASGTSEQTRAVVKEGAIQPLIELLCSPHLTVSEQAVWALGNIAGDCAEFRDCVISNNAIPHLINLISKGIPITFLRNISWTLSNLCRNKDPYPSESAVRQMLPPLCQLLLHRDNEILADTCWALSYLTKGGKEYIHHVVTTGILPRLVELMTSSELSISIPCLHTIGNIVAGTDEQTQMAIDAGMLKVLGQVLKHPKTSIQVLAAWTMSNVAAGPRHQVEQLLCNLLPILVDLLRNAELKVQKEVVCTVINIATGASQDQLTLLAHSGILEPMLSLLSAPDLEVVIIVLDIISYLLQHIDNLQEKKRLYFQIEKFGGFEKIECLQHHHNISISNSALDIIEKYFCEDGDGDSLPGPGLRV
Protein: Intracellular protein transport protein USO1 (Int-1) (P25386)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for protein transport from the ER to the Golgi complex.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Probably present on vesicles operational between the ER and the Golgi complex.
Interaction partners:
- Integral membrane protein SED5
- GTP-binding protein YPT1
- Protein transport protein BET1
- Protein transport protein BOS1
- Golgi SNAP receptor complex member 1
- GRASP65 homolog protein 1
- Protein SLY1
- Synaptobrevin homolog YKT6
- Conserved oligomeric Golgi complex subunit 2
- Protein transport protein SEC13
Sequence:
MDIIQGLIQQPKIQSVDETIPTLCDRVENSTLISDRRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIRGDGHDDLTRGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQSEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMATRPLKARSALISLPTSISTMVSLLDDMHEPIRDEAILLLMAVVNDSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILKYNTSNQTLFLETGNLPKLAHLLSEPISQDEVFFWNDQRIVNINTALDIVSLTVEPGNTVTTKHQNALLDSSVLMVVLRLAFFHNIPKKVRPVALLTAANMVRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILINWMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKLFFTTDIFMFFFQQDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAADIRIPISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFSSKESPFPRKEYFEFITKTLGKDNYASRIKQFKKDSYFSKVDMNEDSILTPELDETGLPKVYFSTYFIQLFNENIYRIRTALSHDPDEEPINKISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKLIALTNEHKELDEKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVEYKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVEISSDEEDDEEDDEEDEEEGQVA
Protein: High-affinity branched-chain amino acid transport ATP-binding protein LivF (LIV-I protein F) (P22731)
Organism: Escherichia coli (strain K12)
Function: Component of the leucine-specific transport system.
Interaction partners:
- High-affinity branched-chain amino acid transport system permease protein LivM
- High-affinity branched-chain amino acid transport system permease protein LivH
- Leucine-specific-binding protein
- High-affinity branched-chain amino acid transport ATP-binding protein LivG
- Leu/Ile/Val-binding protein
- Inner membrane amino-acid ABC transporter permease protein YhdY
- sn-glycerol-3-phosphate-binding periplasmic protein UgpB
Sequence:
MEKVMLSFDKVSAHYGKIQALHEVSLHINQGEIVTLIGANGAGKTTLLGTLCGDPRATSGRIVFDDKDITDWQTAKIMREAVAIVPEGRRVFSRMTVEENLAMGGFFAERDQFQERIKWVYELFPRLHERRIQRAGTMSGGEQQMLAIGRALMSNPRLLLLDEPSLGLAPIIIQQIFDTIEQLREQGMTIFLVEQNANQALKLADRGYVLENGHVVLSDTGDALLANEAVRSAYLGG
Protein: Small ribosomal subunit protein bS16c (30S ribosomal protein S16, chloroplastic) (P0C473)
Organism: Oryza sativa (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MLKLRLKRCGRKQRAVYRIVAIDVRSRREGRDLRKVGFYDPIKNQTCLNVPAILYFLEKGAQPTRTVSDILRKAEFFKEKERTLS
Protein: Cfh protein (Complement factor H) (Q5XJW6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRLSARIIWLILWTVCVAEDCKGPPPRENSEILSGSWSEQLYSEGTQATYKCRPGYRTLGTIVKVCKNGEWVPSNPSRICRKRPCGHPGDTPFGSFRLAVGSEFEFGAKVVYTCDEGYQLLGEIDYRECDADGWTNDIPICEVVKCLPVTELENGRIVSGAAEPDQEYYFGQVVRFECNSGFKIEGQKEMHCSENGLWSNEKPQCVEISCLPPRVENGDGIYLKPVYKENERFQYKCKQGFVYKERGDAVCTGSGWNPQPSCEEMTCLTPYIPNGIYTPHRIKHRIDDEIRYECKNGFYPATRSPVSKCTITGWIPAPRCSLKPCDFPQFKHGRLYYEESRRPYFPVPIGKEYSYYCDNGFTTPSQSYWDYLRCTVNGWEPEVPCLRQCIFHYVEYGESLYWQRRYIEGQSAKVQCHSGYSLPNGQDTILCTENGWSPPPKCVRIKTDCDNLPTFEIAKPTEKKKKSYRSGEQVTFRCPPPYRMDGSDIVTCVNTKWIGQPVCKDNSCVNPPHVPNATILTRHKTKYPSGDKVRYDCNKPFELFGEVEVMCQNGIWTEPPKCKDSTGKCGPPPPIDNGDITSLSLPVYAPLSSVEYQCQNYYLLKGNKIVTCRNGKWSQPPTCLHACVIPEDIMEKHNIVLRWRENAKIYSQSGENIEFMCKPGYRKFRGSPPFRTKCIEGHINYPTCV
Protein: Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) (Q8BQ86)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
- Beta-1,4-N-acetylgalactosaminyltransferase 3
- Carbohydrate sulfotransferase 9
- Glycoprotein hormones alpha chain
- Lutropin subunit beta
Sequence:
MTPRLGTMRLACMFSSILLFGAAGLLLFISLQDPIELSPQQVPGIKFSIRPQQPQHDSHLRISTEKGTRDSPSGSPRGLQLQAPDQPRPHPKAAGSPLRLRQRRRRLLIKKMPAAGTNQGNNSSETFIQPRPRTMDSRWVSLHQTQQERKRVMREACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGIVHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVQFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLRLIHAPGNLTFPRFKDRHSEEARTTSRITHQYFAQLSSLQRQRTYDFYYMDYLMFNYSKPFSDLY
Protein: Angiogenin (EC 3.1.27.-) (Angiogenin-1) (Ribonuclease 5) (RNase 5) (P21570)
Organism: Mus musculus (Mouse)
Function: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus (By similarity). Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA (By similarity). Angiogenin induces vascularization of normal and malignant tissues (By similarity). Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:33758201}. Nucleus {ECO:0000269|PubMed:33758201}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P03950}. Note=The secreted protein is rapidly endocytosed by target cells following interaction with PLXNB2 receptor and translocated to the cytoplasm and nucleus (PubMed:33758201). In the nucleus, accumulates in the nucleolus and binds to DNA (By similarity). {ECO:0000250|UniProtKB:P03950, ECO:0000269|PubMed:33758201}.
Interaction partners:
- Angiopoietin-1 receptor
- Ribonuclease inhibitor
- Angiogenin-2
- Angiogenin ribonuclease 6
Sequence:
MAISPGPLFLIFVLGLVVIPPTLAQDDSRYTKFLTQHHDAKPKGRDDRYCERMMKRRSLTSPCKDVNTFIHGNKSNIKAICGANGSPYRENLRMSKSPFQVTTCKHTGGSPRPPCQYRASAGFRHVVIACENGLPVHFDESFFSL
Protein: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) (Q9EPA7)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity). Can use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones. Protects against axonal degeneration following mechanical or toxic insults. Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury.
Subcellular location: Nucleus {ECO:0000269|PubMed:16914673}.
Interaction partners:
- Nicotinamide phosphoribosyltransferase
- Nicotinamide riboside kinase 1
- Nicotinate phosphoribosyltransferase
- Glutamine-dependent NAD
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- NAD kinase
- Nicotinamide riboside kinase 2
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- NAD kinase 2, mitochondrial
Sequence:
MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL
Protein: Chaperone protein DNAJ, putative (Q57ZD5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVVVGMNRRFLATSAWLGFSNGMTRNLHTAGTVGRGNFFAYLSLPKSPDLDAADVQRSYHKLQRRVHPDLANVQDANNSTEPPGGVVGSVTTSTTTDVANVDDSMYANLSYETLRDPFRRCKYLSRLSRAEAVKGRPLDPLEEEMLMSDDDGRNVEDNKRLQDAGENMSLPEEFLAEMMAANEYVFSPEETNEYRDRLVILIAHLEERHMECYEATKAQWDAEDFQGFRRSVLEWTYVRNILEKAKDCLGNINEAVPKGV
Protein: Nuclear hormone receptor family member nhr-6 (Nuclear receptor subfamily 4 group A member 5) (Steroid hormone receptor family member cnr8) (P41829)
Organism: Caenorhabditis elegans
Function: Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation. Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4. Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage. Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which are generating the spermatheca-uterine valve.
Subcellular location: Nucleus {ECO:0000269|PubMed:20506374}.
Interaction partners:
- Serine/threonine-protein kinase akt-2
- Serine/threonine-protein kinase akt-1
- B lymphocyte-induced maturation protein 1 homolog
Sequence:
MEQLSIQTDELQDQFSNCSPASVDSSYSSCSSVEDEIEIYTRLVRNEEPLRRDFFREMSKNSSCSSSFDYGEFGPSSSSRKGSKTTDADLDSLFHSLVETSDQVNTVPKPTKTEVESIPEEFEQKPSSSSHRLPSEMNASITHIKSELDPTMQAFQMPHNDLFLATAAPHYNPFALSNDFMPNPLMPSFTSPFYPQHFPVSDSRRGSQGTTSSSNNTGGTPSPHSSSLPTSPPQLQGFLRSFLNPDNLSTPTSFGVPSETALDADKMCAVCNDRAVCLHYGARTCEGCKGFFKRTVQKNSKYTCAGNKTCPIDKRYRSRCQYCRYQKCLEVGMVKEIVRHGSLSGRRGRLSSKTKLARSEDQPSPPLPLLALMGKAIEDHTNMTVVRQFMQPFDETIALRILHGELHATKKLLMAMPQISEIQPADFQILLSRSFFAIMAIRVANRCGNSTDTIMFESGELFSLNAFPACFQQIIRFMVDKARTFSSLVDWEPQAFAAFIALQFLAGNTEHNVLGLTNKPLVDQVQSTIINALKDHCSGSQNKLAKIVRLTQEFDVFHALGLQALDILYPSHQLPEEFMFLINLTRAPLRSTDAPPACGSPVAPSGSSLFNFQMGPAAF