wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein sdc-1 (Egg-laying defective protein 16) (P24349)
Organism: Caenorhabditis elegans
Function: Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes. Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Similarly, might contribute to X-linked gene repression through recruitment of the dosage compensation complex to the X chromosomes in hermaphrodites. Seems to be involved in the depletion of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2 pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:11937488, ECO:0000305|PubMed:22393255}. Chromosome {ECO:0000269|PubMed:11937488}. Note=Localizes to X chromosomes in hermaphrodite (XX) animals. {ECO:0000269|PubMed:11937488}.
Interaction partners:
- Sex determination and dosage compensation protein sdc-2
- Zinc finger protein sdc-3
- Lysine-specific demethylase 9
- Dosage compensation protein dpy-30
- Chromosome condensation protein dpy-27
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin complex subunit dpy-26
- Condensin complex subunit 1
- Condensin complex subunit capg-1
- Protein her-1
Sequence:
MSDEEDIDESFEIEEDGISITDARGNSLKAQQIAGKERNLDPEADDLEVVVNFYEAGDGTFQLQLPKLTAVKPVDKVNDVLDFINFDKKVCDGIHSSIKLVSQRDQTGPAPFPKHKLTCAHCDWSFDNVMKLVRHRGVHKNVGVYMCQVCLTLFGHTYNLFMHWRTSCSQTSTTATDIEIQKAETPYLHRNVLNVLGSLNRASQYYCTGGYVFLPSDWCITNKEIVMEKDHMSSCHLCHLPVPNKFLEAHGNVHRGRFRIDGRIYGDYFCHICGTVFIEQDNLFKHWRLHCEEVIAYTPVDQYLSNTELATLAWLVLQTTISQADIECLRVSSSLITEKLAKEHAERHGIANSMHKYYHFPQEIWPLKTFVNLDLVNDAIPISGENSFKIKDPKRPVHIMNLLATACPGFYATGKTFNMICSTKKSESDTKKVYRVILRYTTEGSVIQSYDFTARSFPKLRVDSETPEGVFSHPLADFNVESNEAIVCHKCDSKKLTITFSTEVRLKYHLLRHSESRKDGYHCAICKIIVYNRSHEEHWINDCIPLQKLYRDQKDRECFDAEFAAKCASIIKKLRIRTLIRWKERANEDWVETKQTPDRIGEDFAIKFQVGTTALKTLMAGLEEHYKNAQARHEAYKYSEENFLPPLSTPVVVCFHCGTRCHYTLLHDHLDYCHYWPRNKRLVNEEFHKWKKNGCRNTWRVMKSVAEAMQIEVPFISEEQYSKILDYHTYFCNDTRYKVQDSINNWNDCSTIRDVDLSEKLSVAEIVQKGEDSVMAPEPDIIKNVYFPSARIITDNMLLRMTEINLNDVVQRDPITKEELTGKFKEVQDEQDAILFGDYRAVLRSKGIMVNSISDFVAPPDELAKAKASQESAGQESVDHRNRREREFIQQYMGKDLALEAAARENGRLVEVDEEAEDYELTPKELNARRLVERNRHREMCKTRCEHGEYDYEKFKARQVPINPAKMKERKYLTRVVHESGPDDDVCPDEPENNIIAFSPKYENSLSDFRISAIGFREKYLADDKKKRNGIPIRKMTEAQKGVALDYDTLMARHGGRPDVIMNPAGTVFVGGFVFDRKPTCQDNMQTVYVLRNGYAHRYRIYHCEDTNGIYKFVWPQEQSFDPDSLAKSARVRMVKQVKSPEHMIHHIEEIDESIGHNYRLNRKRRNSETREHELIELDTDDLNEPSTSDGRYSFGHHGYR
Protein: Leukotriene B4 receptor 1 (A0A0A8JWS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MATPLTPVFSGPPVSAVVPAPPSTPPSLPLSHQIGIAILVIAFVFGFPGNLFVVWSVLCRVRRRSVTCLLILNLAVADALVLLSSPLFIRYLVGGKGWEFGPVVCKTVHYLCCVNMYASIYLICLMSMDRWLAVTKPFLSQRLRTKKRLLSIMLAIWVMAFLMALPMPFYRSVVQYKPGVPIYLCNPYHWQSESHEIFQYLSETLLGFLLPFAFILFCYISVILRLRNAMFQRKGRGNFLILIIIAAFTLFWLPYHLINIIQVIGVMQGSSSFLNVAKVGRPNVTAFAFMSSSVNPVLYVFAGSSHIRQAGLGFMAKLFEGTNSEMGSSRSTRSSRGSNTENSVFTKLSVKLNRKGDGAGAETHDGEEGTLADKTLTPLH
Protein: Dual specificity protein phosphatase, putative (Q586S8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVRRGASAMNRQRPGVSGTSPELGKGFGVSMVDVEKVFAVIRFISQHSSSEAVPSVSCNISVGEERSMAAKKGALDSSNALLSSTVDQALERYRMAVTNVPVQLDLVESTRSDLRNVMLEAYADRAAEVNALWECGTKIPLSPGAEQPLFLQGNMYQVQSMHEVVPGLFIGSYHPASNKILLQQRGVTHILCCIDVLPRFPNDFKYMTVPAQDAPNYNISIFFEKTYNFIESAIVGQCSSVLVHCGAGISRAPTIAAAYLIRKLRMPADSVIALIQRKRPVASPNAGFRQQLKKYQRDLGVA
Protein: U1 small nuclear ribonucleoprotein 70 kDa (E7EY23)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTQFLPPNLLALFAPRDPIPFLPQLGKLPHEKHHNQPYCGIAPFIRHFEDPRDAPPPTRAETREERLERKRREKMERRQVVVEGELKLWDPHNDANAQGDAFKTLFVARINYDTTESKLRREFEVYGPIKRIYIVYNKKTGKPRGYAFIEYEHERDMHSAYL
Protein: propanoyl-CoA C-acyltransferase (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (Q57XD5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Peroxisome targeting signal 1 receptor
- hydroxymethylglutaryl-CoA lyase
- Enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative
- Peroxin-13
- Peroxisomal membrane protein PEX14
- RING-type E3 ubiquitin transferase
- Peroxisome assembly protein, putative
- Proteasome 26S non-ATPase subunit 9, putative
- Polyubiquitin, putative
- Ubiquitin-conjugating enzyme E2, putative
Sequence:
MLRRTSSTFSAKRVFVVGGHITTFVGKGSPLFIDKKHPDFGKKENKTLEELLAESINGALQNTGLHDGRAALVDKLVVGNFLGELFSSQGHLGPAAVGSLSGSNSSAFLNKPAVRVEGACASGGLAVQSAWEALLAGTSQIALAVGVEVQTTVSARVGGDYLARAAHYKRQRQLDDFTFPCLFARRMKAIQEAGHFTMEDAAYVAAKAYASGNRNPLAHMHARKVTLDFCTQASDKNPNFLGNEIYKPFLRTTDCSQVSDGGAAVILASEEGLQKLGLSPNDNRLVEIKSLASAAGNLYEDSPDLTRMTTSMVAARTALSMAGVKPEQLQVAEVHDCFTIAELLMYEALGIAEYGGAGALIRSGATALDGRIPVNTGGGLLSFGHPVGATGVKQVLEVYRQMKGQCGEYQMKNIPGIGATLNMGGDDKTAVSMVLTNI
Protein: Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) (Q15386)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains. Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome. Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins. Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages. Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome. Catalyzes ubiquitination and degradation of CAND2.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 D1
- 26S proteasome non-ATPase regulatory subunit 14
- Polyubiquitin-C
- 26S proteasome non-ATPase regulatory subunit 2
- Ubiquitin-conjugating enzyme E2 D2
- 26S proteasome non-ATPase regulatory subunit 4
- E2 ubiquitin-conjugating enzyme
- Proteasome activator complex subunit 4
- Ubiquitin carboxyl-terminal hydrolase 14
Sequence:
MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENTYLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASASCHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS
Protein: UPF0592 protein YDL073W (Q07454)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- High osmolarity signaling protein SHO1
- Signaling mucin HKR1
- Protein OPY2
Sequence:
MGPAIHNQLYECGLKTTSQDGFLMDNYETQLFQSLNRFINFINNANQSASNKEQNTKFCKSSSNFLRLKLLTVLRQWCDSSRSNCTLEVRDVLTQWWVTLLNFLNSDTSLQIDTALELSLSIELTSVCLECLSKIMTILIILPFHSSRDMEIYSHHLLLTIHCITNKLILISKNSKKLKRTNSDDKCSINDKKLQYLNKYSSLLRAFIGKLNAYAFFYLPEDFHFDTILLLTVSPQISSSIQTSLFSWKKRQYKFTDDQGQMIRTEAFENKDTKFFKIIVSYIKNDFVLMSFYWHYWYIILQFMKFSDSDVGIKKSTLSCIPGSEILLTHVTTRFLNSDLNKFTRIIKQTPNPRIANENVTESHPNFKSLNSSNALITSERINDYVFSNFKTIKLWECLRSLSGCILKENHPEYLENMLSLHESLLIDYVSTISAYDYIAANVIYNKVLQFIIFQFESLPSLKFIQWRSWYNGLLSMLRTKNVNCQTVSLLCLFNIWKHVTIEDRDEIVKVLLSDFWESLIFENEFPLIRILFMKVLVFKIIPSVQNSSSLRFLPHDRIKQLYEELLVNKEELFEMQKHDSNDIVAHRKNALVFNGNSRLMMIPKKPNTEDHLVYKINHDKNLTTERFPSVSSVANTRPNVILKNGKYAYDILDEMTSKAAFLLAEKKTRLNPKKNHKIMDGYEGGQENEDNDEDSEDSGSHKNKRKEGNSSLSATLNTWLSKFSSTSEDSQKKKEQANELGNDFEYDEDVADFAEILPKQSSSNIEKIFKHGNNSGSMVSYNSSIKLNRRENILIGPPELRFSNEIKEHNSIATIFKLVFIQTNRRVVEKIDLANMKWGTIHGGSKYMKPLPVPKDLVASVAKNESETRNLATLCGNGLDFEIPVPDFNIFGKCMEDEQDVAKIGNQNVEDLKVTGGREVTIWKQIQDMKLRTRIQKICVLIETFNATVREYFEFSNRLEHDGIFIDFEVRKPSSNNSINIKV
Protein: DNA-binding protein Fis (Factor-for-inversion stimulation protein) (Hin recombinational enhancer-binding protein) (P0A6R3)
Organism: Escherichia coli (strain K12)
Function: Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT-rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}.
Interaction partners:
- tRNA-dihydrouridine synthase B
- DNA-binding transcriptional dual regulator CRP
- Chromosomal replication initiator protein DnaA
- Ribosomal protein L11 methyltransferase
- Sodium/pantothenate symporter
- Uncharacterized membrane protein YhdT
- RNA polymerase sigma factor RpoS
- Integration host factor subunit beta
- Integration host factor subunit alpha
- RNA-binding protein Hfq
Sequence:
MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
Protein: Uncharacterized protein (Q57VQ8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGSAGASSIWMSSLAQLQRLSWDVGRPPLLNHWLNFFVSLRSRNTPQIFTEGPLGVVNNEHKMVNSHTSAAAAAVACTVPLPQEVRQVIAECFVDGVRVAQLKNLLTSPTGILTDASSINICEGNDGVFSEGKRDFCGTTEKKCRDCLSTSPGNAAPGADNHQCDFDEVLFLWCASHETPCHAQQLEAWLREAVGLLHFFTLRPGSKTEQLHIIRPQECLEYSSILCVLLRALCAMFLRSGLNATKGCVAGPTLSISFEEEVGLLSLWLLHSIRCLSVSSFTVLLQLVQMLLASGTKTRAWLLEVPSLLRYDGSGMKGHLNDDLSRKGPAQLWDMWERSPTCRIARDIVPITPNPSSSPSLQQLFTDPHASVGPNVVLSLNEELSQIATSSMGG
Protein: FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) (Q9Y4F1)
Organism: Homo sapiens (Human)
Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
Sequence:
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY
Protein: Uncharacterized protein orf162 (Q2F955)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MNRLFVLFISRFFGKIFFHFPSVLELPFCFFLLLLIFVSLLLLWFLNRGMIHRGTRSPNELDFHFFLFLFTYKFCLETVFLDDGENVLPNPAGDQAQPADAPLAPAVQVPAILNPPRVPSIPSSLDPGRTPEDRVREGTEAAVTGCCSSFVECLCSTWCDSF
Protein: Calcium permeable stress-gated cation channel 1 (ScCSC1) (Q06538)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an osmosensitive calcium-permeable cation channel.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Glycogen debranching enzyme
- Regulator of rDNA transcription protein 7
- Putative uncharacterized protein YDR433W
Sequence:
MTSYIERLKSAASYLDTVPDEHHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQSSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKIDDGNDDDDSESSLIHLVKRIVEGSGDGDNHSAPERTNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEALKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQPYSENYHLLGNEQSGAVTHGENVPSSNNNDEDTILYSQISLGERPKMKIGYRGIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPTAFVTMDSVANAQMAAQAVLDPRVHYFITRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQLLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASNYWAYLSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIGFPLVKIKAKTPRQRNELYNPPIFNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGTLAGFEGGWVLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSSIREYERDNSTVNSANEEESYAYPYAVSELEGPMLD
Protein: DNA-binding protein (Q9KSX6)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Subcellular location: Cytoplasm, nucleoid {ECO:0000256|ARBA:ARBA00004453}.
Interaction partners:
Sequence:
MVMSEITKTLLNIRSLRAYARELTIEQLEEALDKLTTVVQERKEAEAEEIAARAEQEAKLAAIAEQIAKDGIDLEALISALSGETKTKAKGKRAPRPAKYKYIDTNGEEKTWTGQGRTPSVIQKALDEGKSLEEFAL
Protein: Small ribosomal subunit protein eS8 (40S ribosomal protein S8) (Q8MLY8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62241}. Membrane {ECO:0000250|UniProtKB:P62241}; Lipid-anchor {ECO:0000250|UniProtKB:P62241}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62241}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:P62241}.
Interaction partners:
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein eS19A
- IP17351p
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein eL14
- Eukaryotic translation elongation factor 2
Sequence:
MGISRDSAHKRRATGGKRKSLRKKRKFELGRPAANTKLGSGRVHKVRTRGGNTKLRALRLETGNFAWASEGVARKTRIADVVYNASNNELVRTKTLVKNSIVVIDATPFRQWYEAHYVLPLGRKRNPKHAQKEDENDVLTKKRSEKVMKKYLERQKYGKVEQALEDQFTSGRILACISSRPGQCGRSDGYILEGKELEFYLKKIKSKK
Protein: Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) (P11456)
Organism: Bos taurus (Bovine)
Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:7559753}; Single-pass type I membrane protein {ECO:0000269|PubMed:7559753}.
Interaction partners:
- Cation-independent mannose-6-phosphate receptor
- Golgi associated, gamma adaptin ear containing, ARF binding protein 3
- Golgi associated, gamma adaptin ear containing, ARF binding protein 1
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Zinc finger FYVE domain-containing protein 26
- ADP-ribosylation factor 1
Sequence:
MMSPLHSSWRTGLLLLLLFSVAVRESWQTEEKTCDLVGEKGKESEKELALLKRLTPLFNKSFESTVGQSPDMYSYVFRVCREAGNHSSGAGLVQINKSNGKETVVGRFNETQIFNGSNWIMLIYKGGDEYDNHCGREQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTLASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Protein: Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Q9BE97)
Organism: Bos taurus (Bovine)
Function: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P27540}.
Interaction partners:
- Hypoxia-inducible factor 1-alpha
- Neuronal PAS domain-containing protein 4
- Hypoxia-inducible factor 1-alpha
- Aryl hydrocarbon receptor
- Hypoxia-inducible factor 3-alpha
- Neuronal PAS domain-containing protein 1
- PAS fold-3 domain-containing protein
- BHLH domain-containing protein.
- histone acetyltransferase
- histone acetyltransferase
Sequence:
MAATTANPEMTSDVPPLGPAIASGNPGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGTYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNSSVDSVSMNRLSFVRNRCRNGLGSAKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNREWLWVRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPSLSNTIQRPQLGPTANLSLEMGSGQLAPRQQQQQTELDVVPGRDGLTSCNHSQVSVQPVTTTGPEHSKPLEKSESLFAQDRDPRFSEIYSNISTDQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSTSAGQMLAQISRHSNPTQGAAPAWTPSTRPGFSAQQVVTEATAKTRSSQFGVGSFQTPSSFSPMSLPGASTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQSHHRSSSNEQHVQQPSAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPSFSE
Protein: Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt) (P82930)
Organism: Homo sapiens (Human)
Function: Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123}.
Interaction partners:
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein mS25
- Small ribosomal subunit protein uS10m
Sequence:
MARKKVRPRLIAELARRVRALREQLNRPRDSQLYAVDYETLTRPFSGRRLPVRAWADVRRESRLLQLLGRLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYTAQNLDHGKAWGILTFKGKTESEAREIEHVMYHDWRLVPKHEEEAFTAFTPAPEDSLASVPYPPLLRAMIIAERQKNGDTSTEEPMLNVQRIRMEPWDYPAKQEDKGRAKGTPV
Protein: Mitochondrial import inner membrane translocase subunit (Q57XQ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367043}; Peripheral membrane protein {ECO:0000256|RuleBase:RU367043}; Intermembrane side {ECO:0000256|RuleBase:RU367043}.
Interaction partners:
- Tim10-like domain-containing protein
- Mitochondrial translocase subunit
Sequence:
MRLAVKQESFRLEVLMSRLQSECFTFCCKNLSSKELTMDEVKCVERCAVKYLQASDIINRALDKGESGGGAVKQMLKL
Protein: Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) (Neural zinc finger factor 1) (NZF-1) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (P97500)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:28379941, ECO:0000269|PubMed:9373037}. Chromosome {ECO:0000269|PubMed:28379941}. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration (PubMed:28379941). {ECO:0000269|PubMed:28379941}.
Interaction partners:
- POU domain, class 3, transcription factor 2
- Achaete-scute homolog 1
- Neurogenic differentiation factor 1
- Neurogenin-2
- Neurogenic differentiation factor 2
Sequence:
MDVDSEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDKEEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEEDDDDEDGDDVEEEEEDDDEEEEEEEEEEENEDHQMSCTRIMQDTDKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSPRSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYGKDPSRTEKRESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEDEPKEITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV