wanglab/gogpt-training-data huggingface dataset:
Protein: UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase (EC 1.1.1.367) (Q9XC60)
Organism: Pseudomonas aeruginosa (strain ATCC 29260 / BCRC 12902 / CIP 102967 / NCIMB 11965 / PA103)
Function: Bifunctional enzyme that mediates C-3 epimerization of the second intermediate followed by reduction at C-4 during serogroup O11 O-antigen biosynthesis, thus catalyzing the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen.
Interaction partners:
Sequence:
MKVLVTGANGFVGRNLCAHLAERGGIEVVPFTRESSVGNLPELIRSVDFIFHLAGVNRPEKPEEFKIGNSELTYALCEAVRSNGRAIPLLYTSSIQAEVDNEYGLSKRAAEEHLQVLGEDIGCPVYIFRLPNVFGKWSRPNYNSAVATFCHNIIRDIPIQINNSSAEITLVYIDDVVRTFMKVMDGKLSNAVSLQVEPQYQISVGELAEQLYEFRNSRKSLTTARVGSGLTRALYSTYLSFLPEDSFSYDVPMHSDPRGTFVEMLKTADSGQFSFFTAHPGVTRGGHYHHSKTEKFLVIKGMARFKFRNILTGAFYEICTNGEKAEIVETVPGWTHDITNVGTDDMVVMLWANEVFDRENPDTYACSVGEGA
Protein: Histone H3-like 5 (Q9FKQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- Protein TONSOKU
- Chromo domain-containing protein LHP1
- Histone H2B.6
- Lysine-specific demethylase ELF6
- DNA
- Histone acetyltransferase GCN5
- Histone-lysine N-methyltransferase CLF
- Histone-lysine N-methyltransferase ASHH2
- Chromatin structure-remodeling complex protein SYD
Sequence:
MARTKQTARISTGGKAPRKQLAPKAARQSAPATGGVKKPHRFRPGTVALRDIRKYQKSTEILIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKEIQLARRIRGERARGE
Protein: Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B (Q9D1Q5)
Organism: Mus musculus (Mouse)
Interaction partners:
- Cathepsin G
Sequence:
MIRFHAADVKFAVEMYRQLRESDKNIFYSPISMMTALAMLQLGAKGNTEIQIEKVLQFIETTKKTTEKSEHCDDEENVHEQFQKLITQLNKSNDDYDLKAANSIYGAKGFPFLQTFLEDIKEYYQAKVESLDFEHATEESEKKINSWVESKTNGKIKDLFPSGSLSSSTILVLVNAVYFKGQWNRKFNENHTREEKFWLNKNTSKPVQMMKQRNKFNFSFLGDVHAQIVEIPYKGKDLSMFVLLPMEIDGLKQLEEQLTTDKLLEWIKAENMHLTELYLSLPRFKVEEKYDLQVPLEHMGMVDAFDPQKADFSGMSSIPGLVVSKVLHKSFVEVNEEGTEAAAATGVEVSVRSAQIAEDFCCDHPFLFFIIHRMTNSILFFGRICSP
Protein: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (EC 2.4.1.255) (O-GlcNAc) (OGT) (O18158)
Organism: Caenorhabditis elegans
Function: Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine.
Subcellular location: Nucleus {ECO:0000269|PubMed:9083068}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9083068}.
Interaction partners:
- Host cell factor homolog hcf-1
- protein O-GlcNAcase
- EGF domain-specific O-linked N-acetylglucosamine transferase
- Protein sumv-2
- FHA domain-containing protein
- Soluble NSF attachment protein 29
- Bromo domain-containing protein
- Mitogen-activated protein kinase kinase kinase mlk-1
- Histone acetyltransferase
- Histone-lysine N-methyltransferase set-26
Sequence:
MEKPNYFQSYNKVIGATGEQLAPGAVPPHPVLAPSIAPGGVAGVSAANMANIMQTPGFANLVQQAIRTQLENQAAQQLAVNQQFQLNGATAVQQQLLLTPQQSLAQPIALAPQPTVVLNGVSETLKKVTELAHRQFQSGNYVEAEKYCNLVFQSDPNNLPTLLLLSAINFQTKNLEKSMQYSMLAIKVNNQCAEAYSNLGNYYKEKGQLQDALENYKLAVKLKPEFIDAYINLAAALVSGGDLEQAVTAYFNALQINPDLYCVRSDLGNLLKAMGRLEEAKVCYLKAIETQPQFAVAWSNLGCVFNSQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVSAYLRALNLSGNHAVVHGNLACVYYEQGLIDLAIDTYKKAIDLQPHFPDAYCNLANALKEKGSVVEAEQMYMKALELCPTHADSQNNLANIKREQGKIEDATRLYLKALEIYPEFAAAHSNLASILQQQGKLNDAILHYKEAIRIAPTFADAYSNMGNTLKEMGDSSAAIACYNRAIQINPAFADAHSNLASIHKDAGNMAEAIQSYSTALKLKPDFPDAYCNLAHCHQIICDWNDYDKRVRKLVQIVEDQLCKKRLPSVHPHHSMLYPLSHAARIAIAAKHASLCFDKVHVQMLGKTPLIHADRFSVQNGQRLRIGYVSSDFGNHPTSHLMQSIPGMHDRSRVEVFCYALSVNDGTNFRSKLMNESEHFVDLSQIPCNGKAAEKIAQDGIHILINMNGYTKGARNEIFALRPAPIQVMWLGYPSTSGATFMDYIITDAVTSPLRLANAFTEKLAYMPHTFFIGDHAQMLRHLTDKVVVKDKETTERDSCLIMNTANMDPILAKSEIKEQVLDTEVVSGPNKELVRAEMVLPVLEVPTEPIKQMIMTGQMTMNVMEDMNVQNGLGQSQMHHKAATGEEIPNSVLLTSRAQYQLPDDAIVFCNFNQLYKIDPSTLDMWIKILENVPKSILWLLRFPYQGEEHIRKYCVERGLDPSRIVFSNVAAKEEHVRRGQLADVCLDTPLCNGHTTGMDILWTGTPMVTMPLESLASRVATSQLYALGVPELVAKTRQEYVSIAVRLGTDADHLANMRAKVWMARTSSTLFDVKQYCHDMEDLLGQMWKRYESGMPIDHITNNTETPHGL
Protein: NADPH--cytochrome P450 reductase (CPR) (P450R) (PnCPR) (EC 1.6.2.4) (A0A7T9QPQ1)
Organism: Piper nigrum (Black pepper)
Function: Involved in the biosynthesis of aromatic piperamides natural products such as piperine (1-piperoyl-piperidine), the pungent principle contributing, together with several terpenoids, to the aromatic properties of black pepper fruits, and displaying numerous pharmacological activities such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, antiobesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects. Catalyzes the conversion of feruperic acid (5-(4-hydroxy-3-methoxyphenyl)-2,4-pentadienoic acid) to piperic acid. Inactive toward ferulic acid and feruperine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
Interaction partners:
Sequence:
MESGSSIDLSPLDLVAAILQGKADASSLLSLTRSTVSDGNGDLLVLLATSAALLVGLVAALVWRRSAAARTAEPPKPLLAKKEAEPEVDDGKRKVTVFFGTQTGTAEGFAKAFAEEAKARYEKAAFRILDLDDYAADDDEYEEKMKEETLAFFFLATYGDGEPTDNAARFYKWFAEGKDTGNFFEKMQYGVFGLGNRQYEHFNKIAKVVDELLAEQGAKRLVPLGLGDDDQCIEDDFTAWRELIWPELDQLLRNEDDVSGASATYTAAIPEYRVVFYDHEDSRIQEKKNANGYANGHASYDIQHPCLANVAVRRELHTPASDRSCTHLEFDVSGLGLHYETGDHVGVYAENCIETVEKAECLLGLSPATIFSLHTDQVDGTPLSGSFLPPPFPSPCSLRTALAKYADLLSSPKKAALVALASYASEPSEAKRLQFLASPSGKDEYSQWIVANQRSLLEVMAEFPSAKPPLGVFFGAIAPRLQPRYYSISSSPKVAPTRIHVTCALVYEPTPTGRIHKGVCSTWMKNAVPQEESSNCSSAPISVRQSNFKLPMDTSLPVIMIGPGTGLAPFRGFLQERLALKDAGFNLGPAVLFFGCRNRKMDFIYENELNEFVEAGVLSDLIVAFSREGPTKEYVQHKMAEKAVDIWNMISQGGYVYVCGDAKGMARDVHRALHTIVQEQGSMDSSKVESYVKNLQMEGRYLRDVW
Protein: Peroxin 6, isoform D (EC 3.6.1.3) (A1Z8D1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Peroxisomal ATPase PEX1
- Peroxisomal targeting signal 1 receptor
- RING-type E3 ubiquitin transferase
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX14
- Peroxin-7
- Peroxisomal membrane protein PEX13
- Peroxin-19
- Peroxin 11
- Peroxisomal membrane protein PEX16
Sequence:
MKRRVIVKKKKVVGKRNSVSFDQQDPGQPRFSFSGRVQELVEGYNSAIQLLAPKWPWFLYPGYLTYAVYWRYAKYYKGKFLLTPIPNRLYDLLIKNEQIKSEHLVFASQEVYENYAESPDVNFVNLVIRGRRVRIGKPLASDEGNMTQTVIKQMLQEAPHTIVAQILPAAQCQPNCLYVQENFYGNILDRFQIRSNCWVQVEHFADEQTIPGIATKAHVYLVADPHELPAELTEVILSNYFNTPRLMHRGHTYRIEVNAELVGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQVLDSMAIVENYPSGLRKPYKLLRSSVDAFLPKKSACLSSKHIFPVFLLQGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNEGNEDLRLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMIQGLFLEIINIDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKSQGFLLGDLQLLYDNAVRMKIRNRLGRTTLDMSHFAKNLTDMQSSFADSLGAPKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLRRSGILLYGPPGTGKTLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSGGVMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTISEKELVPENVIVQEEDFTKSFNKFVPSISAKDLEYFNNLKASYSV
Protein: Cyclin-dependent kinase 7 (EC 2.7.11.23) (Cell division protein kinase 7) (A0A0S2Z3F9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Protein: Aquaporin-4 (A0A5F9ZHR4)
Organism: Homo sapiens (Human)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell projection {ECO:0000256|ARBA:ARBA00004316}. Endosome membrane {ECO:0000256|ARBA:ARBA00004608}.
Interaction partners:
Sequence:
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSVXLEDRTESRQDSLELSSDFLPPIKETDLL
Protein: Mitogen-activated protein kinase kinase 3 (AtMKK3) (MAP kinase kinase 3) (EC 2.7.12.2) (O80396)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression. Activates by phosphorylation the downstream MPK6, MPK7 and MPK8. MKK3-MPK7 module acts as a positive regulator of PR1 gene expression. MKK3-MPK8 module negatively regulates ROS accumulation through controlling expression of the RBOHD gene. Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Activator of the C group MAP kinases. Activates MPK7 in response to ABA. Mitogen-activated protein kinase (MAPK) that is specifically regulated by MAPKKK20 and mediates signaling that regulates cortical microtubule functions.
Subcellular location: Nucleus {ECO:0000269|PubMed:28848569}. Cytoplasm {ECO:0000269|PubMed:28848569, ECO:0000269|PubMed:30081740}.
Interaction partners:
- Mitogen-activated protein kinase 7
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 2
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 6
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase kinase kinase 18
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase kinase kinase 17
- Transcription factor MYC2
Sequence:
MAALEELKKKLSPLFDAEKGFSSSSSLDPNDSYLLSDGGTVNLLSRSYGVYNFNELGLQKCTSSHVDESESSETTYQCASHEMRVFGAIGSGASSVVQRAIHIPNHRILALKKINIFEREKRQQLLTEIRTLCEAPCHEGLVDFHGAFYSPDSGQISIALEYMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRDIKPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSPERIRNDSYSYPADIWSLGLALFECGTGEFPYIANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDARPTADQLLSHPFITKHEKERVDLATFVQSIFDPTQRLKDLADMLTIHYYSLFDGFDDLWHHAKSLYTETSVFSFSGKHNTGSTEIFSALSDIRNTLTGDLPSEKLVHVVEKLHCKPCGSGGVIIRAVGSFIVGNQFLICGDGVQAEGLPSFKDLGFDVASRRVGRFQEQFVVESGDLIGKYFLAKQELYITNLD
Protein: Delta-amaurobitoxin-Pl1a (Delta-AMATX-Pl1a) (Delta-palutoxin IT1) (Delta-paluIT1) (P83256)
Organism: Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Function: Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects. Has a potent activity against S.litura larvae.
Subcellular location: Secreted {ECO:0000269|PubMed:10971590}.
Interaction partners:
Sequence:
GCLGEGEKCADWSGPSCCDGFYCSCRSMPYCRCRNNS
Protein: Zinc finger protein 593 (Zinc finger protein T86) (O00488)
Organism: Homo sapiens (Human)
Function: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Cytoplasm {ECO:0000250|UniProtKB:Q08004}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:Q08004}.
Interaction partners:
- Probable ribosome biogenesis protein RLP24
- Nucleolar GTP-binding protein 2
- GTP-binding protein 4
- mRNA turnover protein 4 homolog
- Eukaryotic translation initiation factor 6
- Ribosome production factor 2 homolog
- 60S ribosomal export protein NMD3
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Protein SDA1 homolog
- Proliferation-associated protein 2G4
Sequence:
MGRSRRTGAHRAHSLARQMKAKRRRPDLDEIHRELRPQGSARPQPDPNAEFDPDLPGGGLHRCLACARYFIDSTNLKTHFRSKDHKKRLKQLSVEPYSQEEAERAAGMGSYVPPRRLAVPTEVSTEVPEMDTST
Protein: BCL11 transcription factor A (A0A8I6ATN1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
VQSLKKKKPRQATEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE
Protein: Serine/threonine-protein kinase sax-1 (EC 2.7.11.1) (NDR protein kinase) (Sensory axon guidance protein 1) (Q2L6W9)
Organism: Caenorhabditis elegans
Function: Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10982409}. Nucleus {ECO:0000269|PubMed:10982409}.
Interaction partners:
- MOR2-PAG1_N domain-containing protein
- Mob1/phocein
- Mps one binder kinase activator-like 2
- Tyrosine-protein phosphatase cdc-14
- cAMP-dependent protein kinase regulatory subunit
- MOB kinase activator-like 3
- TBC domain-containing protein kinase-like protein
- TYR_PHOSPHATASE_2 domain-containing protein
- Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
- Probable exosome complex exonuclease RRP44
Sequence:
MGEIAPEMEISQYTKDKASCTRISIESYYSKRVTQCAERENRLKKLEEDISARGLSDEEKEEKRKIHHSKETDYLRLKRTRLTVNDFESLKVIGRGAFGEVRLVQKHDTGHIYAMKILRKSEMVEKEQTAHVRAERDILSEADCDWVVKMYYSFQDYSNLYLVMEFLPGGDMMTLLIKKDTLTEEATQFYIAEAALAIQFIHSLGFIHRDIKPDNLLLDARGHVKLSDFGLCTGLKKFHRTDHYRNWPSTLPPDFISKPFESKRKAETWKRNRRAYAYSTVGTPDYIAPEVFQPNGYTKSCDWWSLGVIMYEMLIGYPPFCSELPQETYRKVINWQQTLVFPSDVPISIEAKATIKRFCCEAERRLGNHGGLDEIKQCPFVKRIDWNHIRERPPPIRVTVKSIDDTSNFDDFPDEDLTWPTSTLIRPEEQPGRRGEFVDFTYKRFDGLTQKMRYSDLKKFQQAKKNKKGGQQGTSD
Protein: Protein ups1 homolog (Q9UT07)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C119.18
- UPS-like protein C36.10
Sequence:
MTAICTDKTELNASWNTVSSAWLTRYPNPYSLHVVSADVLERYVDDEGRLYTERLLVKQGRLPRWASDLLNVNKSYILERSVIDPSKQELKSETFNLDHVKILRVIEYSRFIQSSENCSKTIVDTIAKFVSPLRFGLGRRVQKYSLKRFQEQLSSSRRGLLYVIQQKFQPS
Protein: Colicin-E7 immunity protein (ImmE7) (Microcin-E7 immunity protein) (Q03708)
Organism: Escherichia coli
Function: This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.
Interaction partners:
Sequence:
MELKNSISDYTEAEFVQLLKEIEKENVAATDDVLDVLLEHFVKITEHPDGTDLIYYPSDNRDDSPEGIVKEIKEWRAANGKPGFKQG
Protein: Probable respiratory nitrate reductase (Beta chain) NarH (O06560)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
- Nitrate reductase-like protein NarX
- Nitrate reductase alpha subunit
- Probable respiratory nitrate reductase
- Nitrate reductase-like protein NarX
- Probable nitrate/nitrite transporter NarK2
- Probable nitrite extrusion protein 1 NarK1
- Probable integral membrane nitrite extrusion protein NarK3
- Nitrate/nitrite transporter
- Nitrite reductase small subunit
- assimilatory sulfite reductase
Sequence:
MKVMAQMAMVMNLDKCIGCHTCSVTCKQAWTNRSGTEYVWFNNVETRPGVGYPRTYEDQERWRGGWVRDKKGRLRLRDGGRIHKLLRIFANPKLPTIGDYYEPWTYDYENLTSAPAGDTFPTAAPRSLISGNPMKVSWGSNWDDNLAGSPEIVPNDPVLKKVNQVNQEVKLKLEETFMFYLPRICEHCLNPSCVASCPSGAMYKRTEDGIVLVDQDRCRGWRMCVSGCPYKKVYFNHKTGKAEKCTLCYPRIEVGLPTVCSETCVGRLRYLGLVLYDVDQVLQAASVESDTDLYEAQRRILLDPHDPRVIAGARAEGIADEWIEAAQRSPVYALINTYRVALPLHPEYRTMPMVWYIPPLSPVVDAVSRDGHDGEDLGNLFGALDALRIPIAYLAELFTAGDTEVVAGVLRRLAAMRCYMRDINLGRETQPHIPESVGMTEEQIYQMYRLLAVAKYEERYVIPTSYAGELPAAAMTDDMGCSLSVDGGPGMYESGPFGQGSPTPVPIAVESFHALQHAGSAATGGAGRSRVNLLNWDPNGAAAGLFPEPQPSKDVVQR
Protein: Protein EMBRYO DEFECTIVE 514 (Protein DOMINO 1) (Q8L557)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in ribosome biogenesis and in determining the rate of cell division. Involved in a process essential for nuclear and nucleolar functions.
Subcellular location: Nucleus {ECO:0000269|PubMed:15341625}. Note=Does not localize in the nucleolus. {ECO:0000269|PubMed:15341625}.
Interaction partners:
- La protein 1
- At5g12410
- Nucleic acid-binding, OB-fold-like protein
- Eukaryotic translation initiation factor 4C
- ARM repeat superfamily protein
- Single-stranded DNA-binding protein
- AT-hook motif nuclear-localized protein 13
- Thymidylate kinase
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
- DExH-box ATP-dependent RNA helicase DExH13
Sequence:
MAEEQEIVDSLSAEVNPDQKVDMEVETATPKAETGDEKREREETEEEENGGESKKQKVGEEEKSGPVKLGPKEFVTSVAMFDYFVKFLHFWPTDLDVNKYEHMVLLDLIKKGHSEPEKKIGGGIKTFQVRTHPMWKSRCFFLVREDDTADDFSFRKCVDQILPLPENMKTPGANGNGHGGGRGGGGGRRGGRGGGRGGRFRR
Protein: AT-rich interactive domain-containing protein 3 (ARID domain-containing protein 3) (Q940Y3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
Interaction partners:
- Probable nucleolar protein 5-2
- Protein FAR-RED IMPAIRED RESPONSE 1
- Small ribosomal subunit protein uS10m
- Neutral ceramidase 2
- Neutral ceramidase 3
- Shaggy-related protein kinase gamma
- Neutral ceramidase 1
- Probable serine/threonine-protein kinase PBL9
- Probable methyltransferase PMT21
- Histone deacetylase 2
Sequence:
MENLTEIESTMESLTEMESERVEQGTDKEIGSGEKRQDDVKETENENSGERVGEEAPVREHEDSPCLIVIEEGTSLASLEEVTNADDLPKIDDEKNSQFETSPHPSPSPSVALDTEEGLINPTAEDTVEENIVSSEVSSDILKDDGDAVEVDRDTAEVQEETANIPESKLSEDTGSPHHHADILMVQEKAAEEHDMIASGDHEEFPVNPDNKHSEENQSPHHHANNVMEQDQAAEEREIISPGEHKEIPANPDTKVVEENNDRIDEGEANNLNLAGDGSGAVDHDYLTKTELDKVLEVPGSETISKLEDRPSEHLSETSMNVEKELEMPAVEILPDNDKNSDVLAVGVSGDSDNVVSVLPASQTSSDRDEGMITVDAEPTEDMKLDVPDSKLVTDTTVDSTNNKDAHVEANTERQDNSSALVLNDANNESAPVKRVPGPYVASSNIKSEARGSGDLNNGVHKIVRTPPVFDGTMRAKRSFLLDDASDGNESGTEEDQSAFMKELDSFFRERNMDFKPPKFYGEGLNCLKLWRAVTRLGGYDKVTGSKLWRQVGESFRPPKTCTTVSWTFRGFYEKALLEYERHKVSEGELQIPLPLELEPMNIDNQASGSGRARRDAASRAMQGWHSQRLNGNGEVSDPAIKDKNLVLHQKREKQIGTTPGLLKRKRAAEHGAKNAIHVSKSMLDVTVVDVGPPADWVKINVQRTQDCFEVYALVPGLVREEVRVQSDPAGRLVISGEPENPMNPWGATPFKKVVSLPTRIDPHHTSAVVTLNGQLFVRVPLEQLE
Protein: Capsid assembly protein Gp31 (P17313)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Essential for proper capsid assembly. In absence of Gp31 the major capsid protein (Gp23) assembles into 'lumps'. Acts as a co-chaperonin with the host groEL protein.
Interaction partners:
Sequence:
MSEVQQLPIRAVGEYVILVSEPAQAGDEEVTESGLIIGKRVQGEVPELCVVHSVGPDVPEGFCEVGDLTSLPVGQIRNVPHPFVALGLKQPKEIKQKFVTCHYKAIPCLYK
Protein: Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) (P60892)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Interaction partners:
- Phosphoribosyl pyrophosphate synthase-associated protein 1
- Phosphoribosyl pyrophosphate synthase-associated protein 2
- Amidophosphoribosyltransferase
- Transketolase
- Ribokinase
- Ribose-5-phosphate isomerase
- transketolase
- transketolase
- Uridine monophosphate synthetase, isoform CRA_a.
- Phosphoglucomutase-1
Sequence:
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
Protein: Mitogen-activated protein kinase sma-5 (EC 2.7.11.24) (G5EBT1)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase involved in the postembryonic regulation of body size, mainly through control of cell growth. In particular, controls the volume of intestine, muscles and hypodermis. In addition, regulates growth, intestinal granule distribution, lifespan and number of offspring.
Interaction partners:
- Protein dbl-1
- ALK tyrosine kinase receptor homolog scd-2
- histone acetyltransferase
- Multisubstrate adapter protein soc-1
Sequence:
MVFADFLEKIKSLFAKTKDPITSMSPPQENRSPKAEYLNNFFNTNPTNGKSRGSQEAPRKPLGQTNLNVQGSMPAKKEGFNRVLDGLKKRQLQHDFKLERAAETYEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLGIDVFLVMDLMQNNLHHIIYGNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAVGCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINIQDALLHPYIQRVIPAEAPQKKCPFRVKKDMMQVEDLNHQELISMMKQDVRSAENPITYSELHSGDSTGSTSDMSTNTSGEYSPIAQHEQLLEDVATQISICEPTCDL
Protein: Serine/threonine-protein kinase PKH2 (EC 2.7.11.1) (PKB-activating kinase homolog 2) (Q5A3P6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q12236}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q12236}. Note=Localizes at eisosomes, large, immobile complexes that mark sites of endocytosis near the plasma membrane. {ECO:0000250|UniProtKB:Q12236}.
Interaction partners:
- Protein kinase C-like 1
- non-specific serine/threonine protein kinase
- Lipid-binding protein
- Serine/threonine-protein kinase SCH9
Sequence:
MHKFRYSLHQHYSKRNSSDKSKDSPISQNSNEENDSTKLSSSSLQDLHDDLDDIYNNYTLAQGTNNNSVDTLDSENNQAINKFIDKPPAIHGMEPQLPVMHVSSRLSSLGNTTNETGESIAKSAPGTPLSSHSFDFRPHHPRAVTNSSLNVLLDTPNVSSEFNHLVDQTPPNESVERFDDSNNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPELNKAPITTVIKKNVKKSTNSNSNTNNVATAVGGSSSNGHKGSSPTPEKEPSPATINNKSTEKVSAASVAAYVLNKPATNQNSSTSEDSSKRSSNSNETRKLSYSQQDYIPGTNILRPQISTRPSVGSYVKTTPSKDRKTLTKVPSNIHQQQEKVKPKVMEVKPATTLEAAWEPYLTHPDERILRIGPVIAHKEPTEPFEKKNKASLHISPLDINKEQRSRSNTSLLTQIVNEVNNNTSELKKVENADESLAIIEPQYNMKRSPTSDSKKSMDIERSASTSGSRISKKAIFKKLGFSHLEKNDSEESNGPSLTEKPQTCTLVVTTHGRALLFIRNDIESNYLLIAEIKLKYPFIHFQELVISQTKFSKLVPSVGVFVISSIDNSLIFEVEKFEVNQWTEALAKSKYNEIGKR