wanglab/gogpt-training-data huggingface dataset:
Protein: Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) (P70604)
Organism: Rattus norvegicus (Rat)
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P58390}.
Interaction partners:
- Calcium-activated potassium channel subunit alpha-1
- Calmodulin-1
- Calcium-activated potassium channel subunit beta-1
- Small conductance calcium-activated potassium channel protein 1
- Calcium-activated potassium channel subunit beta-4
- Potassium channel subfamily U member 1
- Calcium-activated potassium channel subunit beta-2
- Intermediate conductance calcium-activated potassium channel protein 4
- Small conductance calcium-activated potassium channel protein 3
- Protein kinase C gamma type
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Protein: Kinesin light chain 2 (C9JHT2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDD
Protein: Exostosin family protein (Glycosyltransferase) (Q9SZK4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MTIVKPSQFSFSGGGSSPLCSLKSSLLTVAILTFISLFYLSLNSLRTSPPSPVIVVTPIHVPHTFVNEYKTDNETPTMEEETYSDVYHSPEAFRLNYAEMEKRFKVYIYPDGDPNTFYQTPRKVTGKYASEGYFFQNIRESRFRTLDPDEADLFFIPISCHKMRGKGTSYENMTVIVQNYVDGLIAKYPYWNRTLGADHFFVTCHDVGVRAFEGSPLLIKNTIRVVCSPSYNVGFIPHKDVALPQVLQPFALPAGGNDVENRTTLGFWAGHRNSKIRVILAHVWENDTELDISNNRINRATGHLVYQKRFYRTKFCICPGGSQVNSARITDSIHYGCIPVILSDYYDLPFNDILNWRKFAVVLREQDVYNLKQILKNIPHSEFVSLHNNLVKVQKHFQWNSPPVKFDAFHMIMYELWLRHHVVKY
Protein: LEM domain-containing protein 2 (Nuclear envelope transmembrane protein 25) (NET25) (Q6DVA0)
Organism: Mus musculus (Mouse)
Function: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis. Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (By similarity). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress. Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling. Essential for cardiac homeostasis and proper heart function.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17062158}; Multi-pass membrane protein {ECO:0000269|PubMed:16339967}. Nucleus envelope {ECO:0000269|PubMed:36377660}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NC56}. Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (By similarity). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (By similarity). Recruited to the reforming NE on chromatin disks in early anaphase (By similarity). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (By similarity). {ECO:0000250|UniProtKB:Q8NC56, ECO:0000269|PubMed:16339967}.
Interaction partners:
- Charged multivesicular body protein 7
- Prelamin-A/C
- Emerin
- Barrier-to-autointegration factor-like protein
- Barrier-to-autointegration factor
Sequence:
MAGLSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLRDDERLREDAGPREDAGPRGPERQREEARLREEAPLRARPAASVLRSEPWPLSPSPPAPSAASDASGPYGNFGASASPWAASRGLSYPPHAGPGPLRRRASVRGSSEDDEDTRTPDRHAPGRGRHWWAPPSASARPHSALLGADARPGLKGSRTGSAGAGRTRPEVGRWLERCLSRLLLWASLGLLLGFLAILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCLESARPRMGIGCRLSRALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER
Protein: Ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) (P9WIT9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- N-acetyl-gamma-glutamyl-phosphate reductase
- Argininosuccinate synthase
- Acetylornithine aminotransferase
- Arginine biosynthesis bifunctional protein ArgJ
- Acetylglutamate kinase
- Argininosuccinate lyase
- Arginine repressor
- Carbamoyl phosphate synthase large chain
- Arginine deiminase
- Carbamoyl phosphate synthase small chain
Sequence:
MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS
Protein: Exocyst subunit Exo70 family protein (Q9LQP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component EXO84C
- Exocyst complex component SEC5A
- Exocyst complex component SEC10a
- Exocyst complex component SEC5B
- Exocyst complex component SEC3B
- Exocyst complex component SEC3A
- Exocyst complex component EXO84A
- Exocyst complex component EXO84B
Sequence:
MVLLKPTTLSKSSKVGPQQQQGFSESLIGDSVEAADAFICQWVTPHLCDSSSSSCSLSSLFSAQNRLEGRRFLEVLGKLQYAIQSTVAMNPDSAKLAKGQDLMRKAMKHLEKEFYRVLKSNRRFLSPESVSGWSSESNIPSRSSGTASDSSSDGELYSESSSELGKDIGGGGNSDAIVDLKMIANCMISSGYEKDCVKIYKKFRKKIIVDTLSHLGFEKLTSTQMQKLEWEILEKKIKIWVIVARVAITTLFNGERILSDHIFSSSVAESCFVDITLQSALNLFIFSLTVAKSRKTAEKIFPTLDVYQTILQLTPKIDQIFSYDSTAAVRLQANESLEKLSESVNAMMTEFQSSITKESSKSAISGGGVHQLTRYVMNFIVFLADYSDSLATILKESSLPLPEDYFSSSGEENPGSGDRSPMAARLAWLILVLLCKIDAKSRLYNDSALSYLFLANNLHYVVTKVRTSNLRLVLGDDWVANHEVKVNQYLEKYEKMAWGDVIASLPGDSTAGTEAEESLRRFNEAFEEAYKKHKTWVVPDPNLRDEIQASIARKLMPGYTGFYKKHPVGSCNIVRFTPEDLNNYITDLYVGLGRSVPVSKTKKYMVSPSHTTDLK
Protein: Uncharacterized protein YjjU (EC 3.1.1.-) (P39407)
Organism: Escherichia coli (strain K12)
Function: Probable lipid hydrolase.
Interaction partners:
- Uncharacterized metal-dependent hydrolase YjjV
- Osmotically-inducible protein Y
- NTE family protein RssA
Sequence:
MGQRIPVTLGNIAPLSLRPFQPGRIALVCEGGGQRGIFTAGVLDEFMRAQFNPFDLYLGTSAGAQNLSAFICNQPGYARKVIMRYTTKREFFDPLRFVRGGNLIDLDWLVEATASQMPLQMDTAARLFDSGKSFYMCACRQDDYAPNYFLPTKQNWLDVIRASSAIPGFYRSGVSLEGINYLDGGISDAIPVKEAARQGAKTLVVIRTVPSQMYYTPQWFKRMERWLGDSSLQPLVNLVQHHETSYRDIQQFIEKPPGKLRIFEIYPPKPLHSIALGSRIPALREDYKLGRLCGRYFLATVGKLLTEKAPLTRHLVPVVTPESIVIPPAPVANDTLVAEVSDAPQANDPTFNNEDLA
Protein: Bromodomain containing 1 (D3ZUW8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Histone acetyltransferase KAT7
- Histone acetyltransferase KAT6A
- Chromatin modification-related protein MEAF6
- histone acetyltransferase
- Bromodomain and PHD finger containing, 3
- Inhibitor of growth protein
- Inhibitor of growth protein
- Bromodomain and PHD finger containing, 1
Sequence:
MRRKGRCHRGSAARHPSSPCSIKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEVLPSTHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIINEKRKGDCVSAVSQNMFEFLMDRFEKESYCENQKQGEHQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGSTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRNTQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQMAMELRLTPLTVLLRSVLEQLQEKDPAKIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNLHAFEEDFNLIVDNCMKYNAKDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPIAAPRRPFSWEEVDRLLDPANRAHMSLEEQLRELLDKLDLTCSMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQTPSIGAGTGGFEDDAAPLAPDTGEEGDKSPPKLEPSDALPLPSDPETNSEPPTLKPVELNPEQSKLFKRVTFDNESHSTCTQSALVSGHPPEPTLASSGDVPAAAASAVAEPSSDVNRRTSVLFCKSKSVSPPKSAKNTETQPTSPQLGTKTFLSVVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDTGLTNGFGGTRSEQEPGSGPGRKAAPRRRCASESSICSSNSPLCDSSFSTPKCGRGKPALVRRHTLEDRSELISCIENGNYAKAARIAAEVGQNSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEHMQTKSEEKLFLVLFFDNKRSWQWLPKSKMVPLGVDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPASDLSDID
Protein: GH18 domain-containing protein (G8BHR3)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- chitinase
Sequence:
MLQQFFIVLLLSITTALAATNSIALYWGQNIAAGQSRLNYYCQNSDVEIVILSSITDFTTGYGDFDYNCYKNRTTGYMTCPNFAEDIKSCQASGKKVLLSIGAPGSRSQFANPQQAEALADTLWNKFGTGQSDEKPFGDAIIDGFDFHIASGGSTGYAELAQALRSKFDSSKKYYLSASPTCTFPNPQLGPLLSQVPLDYTFIQYYDGQCSPNRGINYDSWSQFADTAPNPNMKLYLGLYTFDLSSNFISTRNLPPIIDRVNCDPHFAGVALWDASGAFLRETSNGRYIDNVKRVLDEEVCPEPSSSAEPTSSAEPTSSEEPSSSEEPTSNEEPSSSTEPTSSEEPSSSEEPTSSEEPSSSTEPTSSKEPSSSEEPTSSEEPSSSAEPTPSQEPSSSEEPTSSEEPSSSAEPTPSQEPSSSEEPSSSGETTSSEEPTSSAEPTSSAEPTSSEEPSSSEEPTSSKEPSSSGEPTSSEEPTSSAEPTSSTEPSSSAESIAFTDSSLSADSSSTTEPSSSVETSSIKESLSGENISTSSPTESPPATKPFSPSASTSFSSSPDEETTTTKLKDEDATSIVVGTTVVTITSCSNDVCVTTSVTTGLTTVTDESTTFTTFCPLPTKSTKESSNGEGGGKETPKTREQEISTTTVTVTSCNENDVCNEYPVTTGVTTITDDFTTYTTYCPLPIITTTIAATTDGGFDDNGSEGAASDSSNEQIDTTTVTITTCQKDKCFTVPVVTGLTTVTKSNTVYTTYCPLPTTDTAIAEASQGESEPGTAKTEVVIETSVSVTKGEETIVVGATVTVTDEADETELTTVTIGGAGSGGAGEEMTTAANTVAPITTTSVAQEESPKSISSVQVSEQQQTVAVESSQSSSSRVPESSVSVYEGVGVGFESFRMGSVFTLPLFLLTLIV
Protein: Probable transcriptional regulatory protein STB4 (P50104)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to SIN3.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein STB6
Sequence:
MSINHEIYYILVFEHRSVAIKLIIVVIVLLQFFLARSRQIDRTWAHTNRKERFREMTAIGNTDDALDTSTAASKENGKGRLRVQKACELCKKRKVKCDGNNPCLNCSKHQKECRYDFKATNRKRRRRQVASAVRDVSKTYAETSESFPRDLLSKSNIIINAPSDGVSSSASNSPNPNSHYHHISSTLPFMSGRPNHTFHSGSNLNGENNNNSFPEDHMAKLLLQLSSKLGNTTKESSIRTTRTNASDVNANPTVVNMKNSQEDCDTNHRSAICDSAEALHNNNINSKENKIINSQITNTVNDHFESPWQTFSLDKYRFHRRYQNILPYYLGVSILKDLSPQTIEYAKLKRPRVQNYGWNLSGGHYLKYKGDFRSQEKNIRHESKFFDFDDPVHLSLINKLLRYYFDEINPVFSIIHEATFWQQYNNKFLRQGKQNNSSANLFTSMLYLILSTTLRFREGHLDGQKGQGTYSNTSLNITFEEKSILIKKPSIEENLFKYAYLIINTLTFEWESFELIQSWLLITFYFRTCYRQTACWNALSQAVNMCNGMSLYLNKFPEIHSTYDESKAWHCFWCCFIMDKLISFQMGRFYQLSLPASEMCEQMNLVKSKKFLQEEDDWFHEETFQMLDLSIIVTQFLKRDAQDLNLNETVQLRSQLGQWYDTFIVGSQTNAYDDNYRYFYQVQPFMTYLDIRLTFEVRQLFCLIAPSSTANNKSLEYVVDTELLISHCQMAIENLAEITRSNLFFVPWWLNLSQLFTVNLICIIYLHAGIAVTQNKAIMQSCQEIWRTLECSKPKNRPSMLPECLWCLKMLNHMFCIRLRDSALQLEATLGTDHGDDTPNRNKFEQFKKVGDNDADVEVDAGEREENADERQENPHNNSKRVPLATRSHNTTNFDGSIAISPESAVANLGTDTGLPSDVLDTVSKIGNSPNVFDDDLFSNLLWFDQNFA
Protein: C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))] (P10147)
Organism: Homo sapiens (Human)
Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Subcellular location: Secreted.
Interaction partners:
- C-C chemokine receptor type 5
- C-C chemokine receptor type 1
- C-C chemokine receptor type 2
- C-C chemokine receptor type 3
- C-C motif chemokine 4
- C-X-C chemokine receptor type 3
- C-X-C chemokine receptor type 4
- C-C motif chemokine 3-like 1
- Tumor necrosis factor
- C-X-C chemokine receptor type 2
Sequence:
MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA
Protein: Exonuclease V (X6RF29)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISLQNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASIHLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGVIDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFD
Protein: bZIP transcription factor hapX (Iron acquisition regulator hapX) (Q4WER3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- CCAAT-binding factor complex subunit HapE
- CCAAT-binding factor complex subunit HapC
- GATA-type transcription factor sreA
- Calmodulin, putative
- Transcriptional activator HAP2
- Tropomyosin, putative
- L-ornithine N
- MFS siderochrome iron transporter B
Sequence:
MSTPSIAPAPAPLVPALAAKPAISPSPGPGTPGSITSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVNELEEQIKKIEDEHEIHIAAFKEQITNLSREVEQCRSEMTWWRDRCHALEKEVSVERSAKEAIVKEFRSSLSDREAVRSDKGLAPLTTSTPQARSSDRPDNGDASNNDSGEGREEVPLGCNDCSTSHCQCIEDAFTMPGVVAQEQSRRLDTTKPGLSEPQIKPDPEEMEIDFTSRFAATQQQDQSPTSVSSPAVDPCGFCSDGTPCICAEMAAQEEQRPRRNSFENNRLAPIQNLSQFTPPPSDGDVRSDVTLPPISQATNPCANGPGTCAQCLADPRRTLFCKTLAASRSPSAAPSGCCGGKGADGGCCQSRNTNVSRGRSGSNNNTSSGSSAAPSLTLSCADAYTTLSRHPNFSRATDELSTWLPKLHTLPKPRDFPLTDRGVPRAALEVEAASVMGVLRYFDRRFADK
Protein: Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) (Q8TF47)
Organism: Homo sapiens (Human)
Function: Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61967}. Note=Colocalizes with REST in the nucleus. {ECO:0000250|UniProtKB:Q61967}.
Interaction partners:
- Transcription intermediary factor 1-beta
Sequence:
MAPRPPTAAPQESVTFKDVSVDFTQEEWYHVDPAQRSLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWISEGEIQRPFYPDWKTRPEVKSSHLQQDVSEVSHCTHDLLHATLEDSWDVSSQLDRQQENWKRHLGSEASTQKKIITPQENFEQNKFGENSRLNTNLVTQLNIPARIRPSECETLGSNLGHNADLLNENNILAKKKPYKCDKCRKAFIHRSSLTKHEKTHKGEGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSSNYSIDFKHSTSLTQDESTLTEVKSYHCNDCGEDFSHITDFTDHQRIHTAENPYDCEQAFSQQAISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECNECGRAFRKKTNLHDHQRIHTGEKPYSCKECGKNFSRSSALTKHQRIHTRNKL
Protein: DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16) (O15514)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:9852112}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB9
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB11-a
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- Transcription elongation factor SPT5
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY
Protein: Transcriptional adapter 2A (dADA2a) (Q7KSD8)
Organism: Drosophila melanogaster (Fruit fly)
Function: GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:12482983, ECO:0000269|PubMed:12697829, ECO:0000269|PubMed:18327268}.
Interaction partners:
- Transcriptional adaptor 3, isoform C
- histone acetyltransferase
- SAGA-associated factor 29kDa
- Ada2a-containing complex component 1
- SAGA complex subunit Spt3
- Ada2a-containing complex component 2
- Transcription initiation factor TFIID subunit 9
- D12
- Host cell factor
- DNA-directed RNA polymerase II subunit Rpb4
Sequence:
MSFMNPVDMVDEDAADLQFPKVALLHIFTTLNCLFAVEPLGPQVKRFIHAHQNEHTRNSMVLYNPHTLHRYLEEMEEKTRDQNSSVPSATKDANRCATCRCSLTEPYIKCSECLDTLLCLQCFSRGKEAFSHRNNHAYIIVRDNIQVFADEPHWTARDERILLKTLRTHGYGNWEAVSQALDQRHEPAEVRRHYHDCYFGGIFERLLNLKHARDSYVPERMPYVFKMRSLDPPRHDDIASMQFRLSAGYRCARGDFDTPYDTSAESLLSIMVDHRGRDDDNEASESEFEREVTEELQLGLVRAYNNRLRERQRRYKIMRQHGLIMPNRTVSWISKYVHAFGSDASCMRFLGFMQICPDPIKFDMLLESLRYYRELHSQLHKLYDLREHGVRTLSGAKLYARLSKERQQAQRDYSRLKQTDAFDWQQLVQHYESNRSGDPGPLAINSKLYVMNTRRKASPIEIGGGKHFTHCLTPTEYNFSLIPDLPGYSKLDDGERKLCSVARLVPQSYLDYKNQLVTEQAKLGYLRLADARRLIKIDVNKTRQIYDFLLEHGHISRPPSYG
Protein: Probable WRKY transcription factor 19 (WRKY DNA-binding protein 19) (Q9SZ67)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. May act also as a disease resistance protein with a serine/threonine-protein kinase activity (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Putative defensin-like protein 26
- Duplicated homeodomain-like superfamily protein
- PX domain-containing protein EREL2
- PX domain-containing protein EREL1
- PX domain-containing protein EREX
- Lysine-specific demethylase ELF6
- Chromatin structure-remodeling complex protein SYD
- Protein PHOX1
Sequence:
MSEKEELPLTLTSIGAATATSDYHQRVGSSGEGISSSSSDVDPRFMQNSPTGLMISQSSSMCTVPPGMAATPPISSGSGLSQQLNNSSSSKLCQVEGCQKGARDASGRCISHGGGRRCQKPDCQKGAEGKTVYCKAHGGGRRCEYLGCTKGAEGSTDFCIAHGGGRRCNHEDCTRSAWGRTEFCVKHGGGARCKTYGCGKSASGPLPFCRAHGGGKKCSHEDCTGFARGRSGLCLMHGGGKRCQRENCTKSAEGLSGLCISHGGGRRCQSIGCTKGAKGSKMFCKACITKRPLTIDGGGNMGGVTTGDALNYLKAVKDKFEDSEKYDTFLEVLNDCKHQGVDTSGVIARLKDLFKGHDDLLLGFNTYLSKEYQITILPEDDFPIDFLDKVEGPYEMTYQQAQTVQANANMQPQTEYPSSSAVQSFSSGQPQIPTSAPDSSLLAKSNTSGITIIEHMSQQPLNVDKQVNDGYNWQKYGQKKVKGSKFPLSYYKCTYLGCPSKRKVERSLDGQVAEIVYKDRHNHEPPNQGKDGSTTYLSGSSTHINCMSSELTASQFSSNKTKIEQQEAASLATTIEYMSEASDNEEDSNGETSEGEKDEDEPEPKRRITEVQVSELADASDRTVREPRVIFQTTSEVDNLDDGYRWRKYGQKVVKGNPYPRFSSSKDYDVVIRYGRADISNEDFISHLRASLCRRGISVYEKFNEVDALPKCRVLIIVLTSTYVPSNLLNILEHQHTEDRVVYPIFYRLSPYDFVCNSKNYERFYLQDEPKKWQAALKEITQMPGYTLTDKSESELIDEIVRDALKVLCSADKVNMIGMDMQVEEILSLLCIESLDVRSIGIWGTVGIGKTTIAEEIFRKISVQYETCVVLKDLHKEVEVKGHDAVRENFLSEVLEVEPHVIRISDIKTSFLRSRLQRKRILVILDDVNDYRDVDTFLGTLNYFGPGSRIIMTSRNRRVFVLCKIDHVYEVKPLDIPKSLLLLDRGTCQIVLSPEVYKTLSLELVKFSNGNPQVLQFLSSIDREWNKLSQEVKTTSPIYIPGIFEKSCCGLDDNERGIFLDIACFFNRIDKDNVAMLLDGCGFSAHVGFRGLVDKSLLTISQHNLVDMLSFIQATGREIVRQESADRPGDRSRLWNADYIRHVFINDTGTSAIEGIFLDMLNLKFDANPNVFEKMCNLRLLKLYCSKAEEKHGVSFPQGLEYLPSKLRLLHWEYYPLSSLPKSFNPENLVELNLPSSCAKKLWKGKKARFCTTNSSLEKLKKMRLSYSDQLTKIPRLSSATNLEHIDLEGCNSLLSLSQSISYLKKLVFLNLKGCSKLENIPSMVDLESLEVLNLSGCSKLGNFPEISPNVKELYMGGTMIQEIPSSIKNLVLLEKLDLENSRHLKNLPTSIYKLKHLETLNLSGCISLERFPDSSRRMKCLRFLDLSRTDIKELPSSISYLTALDELLFVDSRRNSPVVTNPNANSTELMPSESSKLEILGTPADNEVVVGGTVEKTRGIERTPTILVKSREYLIPDDVVAVGGDIKGLRPPVLQLQPAMKLSHIPRGSTWDFVTHFAPPETVAPPSSSSEAREEEVETEETGAMFIPLGDKETCSFTVNKGDSSRTISNTSPIYASEGSFITCWQKGQLLGRGSLGSVYEGISADGDFFAFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQHQNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQRNQLGDSVVSLYTRQILDGLKYLHDKGFIHRNIKCANVLVDANGTVKLADFGLAKVMSLWRTPYWNWMAPEVILNPKDYDGYGTPADIWSLGCTVLEMLTGQIPYSDLEIGTALYNIGTGKLPKIPDILSLDARDFILTCLKVNPEERPTAAELLNHPFVNMPLPSSGSGSVSSLLRG
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit (Q7TNL5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSYKLKKDKQEPSKLAKGTAKPSSSSKDGGGENTDEAQPQPQSQSPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSFPFNLNKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKCKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKVFLVRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARILPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
Protein: Histone deacetylase (EC 3.5.1.98) (J3KPH8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037911}.
Interaction partners:
Sequence:
MSDLRKRELGALFTSRGTGGVEWDGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHMGALTLSQIPGHGSSQQQAGGAFSWPGHPCRAAVVMVNTGAACSAWPPVQTPGCLECQGLTKKKWRQ