wanglab/gogpt-training-data huggingface dataset:
Protein: B-cell CLL/lymphoma 6 (Zinc finger protein 51) (Q6PC08)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MACAADSCIQFTRHASDVLLNLNRLRSRDILTDVTILVNRQQFRAHKTVLMACSGLFYSIFTDSHKCNLNAISLDPKVDPEGFAILLEFMYTSRLALKESLIMAIMNTAIYLQMDHVVDTCHRFIKSSDSSIKLPREDFLVSPLLLPQDIHSYRPHEVMDNVSGRSATFRDGRPYGVCMFNGVNAPNNSYLYGQFPMQGFPFPLCKLTDTKNTFSDFSKGGIIHHKHCSPSDGNNPVLNDFTRSATSGSSAVCHTGSYSSRELGRDEDMKRETLEGVVHSIGMSSRKHGFISLAQEQQRESGKEQSSLAEEHLSHQHYSMGISSNGRKTLMSSPQSPLKSDCQPNSPTESSSSKNAALAQALQPPTTQGTSDPKARNWKKYKFIVLNQSSKEEETNPPDPGMHSPQRPGLSAFLHHVDSEHPDSKVTTKISEQGEDFPAPQASRLNNIINRSLEGSQRNVDSHSSLYMNHLKCSSCGSQSPQHSDVCPNTSASRLAEEMSEMHSEYSDSSCENGTYFCNECDSKFAEEEALKRHTLQVHSDKPYKCDRCQAAFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKIQYRMSSTELPTDLTKAC
Protein: Double-stranded RNA-binding protein 1 (Protein HYPONASTIC LEAVES 1) (dsRNA-binding protein 1) (AtDRB1) (O04492)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation. Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS). Involved in several plant development aspects and response to hormones through its role in miRNAs processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:14722360, ECO:0000269|PubMed:17337628, ECO:0000269|PubMed:17442570}. Nucleus speckle {ECO:0000269|PubMed:26227967}. Note=Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm and involved in miRNA processing.
Interaction partners:
- Endoribonuclease Dicer homolog 1
- Probable elongation factor 1-gamma 2
- Serrate RNA effector molecule
- Protein DCL homolog, chloroplastic
- Small RNA 2'-O-methyltransferase
- Protein argonaute 1
- G patch domain-containing protein TGH
- Endoribonuclease Dicer homolog 3
- Protein HASTY 1
- Protein SUPPRESSOR OF GENE SILENCING 3
Sequence:
MTSTDVSSGVSNCYVFKSRLQEYAQKYKLPTPVYEIVKEGPSHKSLFQSTVILDGVRYNSLPGFFNRKAAEQSAAEVALRELAKSSELSQCVSQPVHETGLCKNLLQEYAQKMNYAIPLYQCQKVETLGRVTQFTCTVEIGGIKYTGAATRTKKDAEISAGRTALLAIQSDTKNNLANYNTQLTVLPCEKKTIQAAIPLKETVKTLKARKAQFKKKAQKGKRTVAKNPEDIIIPPQPTDHCQNDQSEKIETTPNLEPSSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLEPSSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLESSSCMSGLKEAAFGSVETEASHA
Protein: Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) (P24368)
Organism: Rattus norvegicus (Rat)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P23284}. Melanosome {ECO:0000250|UniProtKB:P23284}.
Interaction partners:
- Cartilage associated protein
- Prolyl 3-hydroxylase 1
- Protein disulfide-isomerase A4
- Cartilage associated protein
- Endoplasmin
- Protein disulfide-isomerase
- Endoplasmic reticulum chaperone BiP
- DnaJ homolog subfamily B member 11
- Hypoxia up-regulated protein 1
- Calreticulin
Sequence:
MLRLSERNMKVLFAAALIVGSVVFLLLPGPSVANDKKKGPKVTVKVYFDFQIGDEPVGRVTFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTSWLDGKHVVFGKVLEGMDVVRKVENTKTDSRDKPLKDVIIVDCGKIEVEKPFAIAKE
Protein: Dynein light chain (Q5BL99)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU365010}.
Interaction partners:
- Dynein light chain roadblock
- BCL2 modifying factor 1.
- Si:dkey-148f10.4.
- Dynein light chain Tctex-type 1
- Dynein light chain roadblock-type 2.
- Dynein light chain Tctex-type 1
- Cytoplasmic dynein 1 intermediate chain 1
- Dynein, cytoplasmic 1, intermediate chain 2a-like isoform X2
- Dynein, cytoplasmic 1, intermediate chain 2a
- WD_REPEATS_REGION domain-containing protein.
Sequence:
MTDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
Protein: Calcyclin-binding protein (CacyBP) (Q6AYK6)
Organism: Rattus norvegicus (Rat)
Function: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- E3 ubiquitin-protein ligase SIAH1
- Protein S100-A6
- S-phase kinase-associated protein 1
- Catenin beta-1
- E3 ubiquitin-protein ligase SIAH2
- Beta-catenin-interacting protein 1
- Glycogen synthase kinase-3 beta
- Glutaredoxin-3
- Adenomatous polyposis coli protein
Sequence:
MASALEELQKDLEEVKVLLEKSTRKRLRDTLTNEKSKIETELRNKMQQKSQKKPEFDNEKPAAVVAPLTTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPAENVQVHFTERSFDLLVKNLNGKNYSMIVNNLLKPISVESSSKKVKTDTVIILCRKKAENTRWDYLTQVEKECKEKEKPSYDTEADPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAREDTEF
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q7KTB8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
Sequence:
MADDTSSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQVFSYIGSVVIVYLGALIGTRKIFIQLFGNILHAPQAYFDIKPRARILDRLANDIYKLDVVLPELIRVFNSQVFRVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV
Protein: Putative B3 domain-containing protein REM15 (Protein REPRODUCTIVE MERISTEM 15) (O23076)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326}.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS7z
- Small ribosomal subunit protein uS7y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS21y
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS1z
Sequence:
MAHQHFFKPLLPGFHASLTIPVAFFLKYIEGRYEQKTAKLRSDASKRTWEVKIDGQRLTDGWKEFAVSHDLRIGDIVVFRQESDLAFHVTLLGPSCCGIQYGSCSVEKNNLGDEKKKVKENPNGEAESSSRDPSCFVANVAPSSLRYDLMRFPRGFVRDNGVVGSGEIVLMNEKGRSWNFNLRQKPSNGTVYVRGGWVSFCDANGLKAGDNYTFKLIKRAGTLVLRLLPNEPKEEANEVSLPEEPESDAERNLEKIQRKEKVKKNVTREAESSSQDPSCFVANVSPSSLRYDTLYLPKRFMRENGVDKRCGEMILINEKGKSWTLDLKVKKSSGTSLIKRGWRSFCSANGLRAGSIITLKLIKKRATLVLRLIPNEPEEANEVVSLSTEQESDEESIHDEKISRRKSLLSENRFVTLTLTPYTIQSSLLNENLLCESMFQRLPVPFTRMNGINEETKMTLLDKHGVKWLTTLRFEDDKRKRLRMVGGWQGFIQANDVKANESIMLELIWEEETSCVLKFCSKVKLEIK
Protein: General transcription factor IIH subunit 4 (Q95TQ5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364024}.
Interaction partners:
Sequence:
MTNTLDKDSKPRDIAFLDTYAMSRWRCVLHYMVGTGNRNGTDAEAISPDAVRILLHANLMKRDERDGITITRQGFQFLLLDTRAQVWHFMLQYLDTCEERGISLPECLSMLFQLSFSTLGRDYSSEGMNSQMLTFLQHLREFGLVFQRKRKEGRFYPTRLALNVTSKEAAATASVAMDEEATQDCGYIVVETNYRVYAYTDSPLQVAVLGLFTELLYRFPNLVVGVLTRDSVRQALRGGITAEQIVSYLEQYAHPNMRMVESAIHSKSCLPPTVVDQIKLWELERNRFTYTEGVLYNQFLSHTDFVTLRDYAQSIHMLVWQNERTRTMVVQKNGHDDVKRYWKKYSKSGV
Protein: Paired box protein Pax-8 (W0S4A0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSNNTGRGGMFVNGRPLPEVIRQRIVDMAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIADYKRQNPTMFAWEIRDRLLAEGVCDSDTVPSVSSINRIIRTKVQQPFNLPLDGKGLSPGHILIPSSAVTPPESPQSDSLGSTYSISGLLGIPQPSQEGKRSHDDSDQESCRHSVDSQGSGGVPRKQLRPEHFPPQHLDCGFDRHHYPPDSFSSAAASKTEQTVYPLSLINGSLEDGKTSLSTSSAAIGRNLAAHQGYTVVAGKTLTMDAAFSPCTNIRA
Protein: Plus3 domain-containing protein (Q382U3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTNYALASQCQLRRDELGELLALATIVESHSKMPGSVDGGVGNNSISTESSDRNAIVALWHTFLTSAHVRSLTTDTLVRVSIPKSKQQLLIHDNEHIRPAAQSSESTKNKQQYYRLGSVMTIVPHPRVVPENQQTTATNANDVGTAAHLSSWLLQINFGDVADLLSAKYVSNEPFTAEEHTVYVRSYVAKCLNSNIPLSSTSYAEVVARNVKDIHRFVEAVKVHRKGNGETALQPSSGVTLGATKRLRSEVGDVGDGVDNDSDDDDFTYRTVGNGYGSDKHDRQAKLVEDQERRLVALRQHLNSKNNELQRLLQAQKRAAADHLAQQEQWNIKAESQGTALRRAEKELVEERAKRQQQQEKTDKLITQLKRLAEQTRKFKDVSDTVAEWLCVSSRQPEEVRARVQEKMAENKN
Protein: Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) (A0A1U9X845)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004473}.
Interaction partners:
Sequence:
MAPALLLIPAALASFILAFGTGVEFVRFTSLRPLLGGIPESGGPDARQGWLAALQDRSILAPLAWDLGLLLLFVGQHSLMAAERVKAWTSRYFGVLQRSLYVACTALALQLVMRYWEPIPKGPVLWEARAEPWATWVPLLCFVLHVISWLLIFSILLVFDYAELMGLKQVYYHVLGLGEPLALKSPRALRLFSHLRHPVCVELLTVLWVVPTLGTDRLLLAFLLTLYLGLAHGLDQQDLRYLRAQLQRKLHLLSRPQDGEAE
Protein: Ryanodine receptor type 1 (Q90984)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
KDVGHYRMAPPDAPGGLGDIGEPPGAEPPTPEGTPILRRKIGEDGKEVVEEPQKEEEAAAETEKADTENGEKGDGGAEGGPEVETPEKQQKAPPPRERKEPPPPEAFEFWTELEVQRVKFLNYLSRNFYNLRFLALFLAFAINFILLFYKVSERPPGMEEAEVEGSGMAAVLDGIGDFGDGGDGDGDGGEGAEEPSVVYYCLEESTGYMQPPARLAVAHTIVAFLCIIGYNCLKIPLVIFKREKEVARRLEFSGLYITEQPPDDDVKGQWDRLVLNAQSFPSNYWDKFVKRKVLEKYGDIYGRERIAELLGMELSSLEIGARGERKPPPDNSVLTWITSIDIRYQIWKFGVIFTDNSFLYLTWYMAMSLLGHYNNFFFAAHLLDIAMGVKNVRTILSSVTHNGKQLAMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEEPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFLCGIGSDYFDTTPHGFETHTLEEHNLANSMFFLMYLINKDDTEHTGQESYVWKMYQERCWDFFPAGDSFRKQYEDQLG
Protein: Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3) (Q9BZV2)
Organism: Homo sapiens (Human)
Function: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Thiamine transporter 1
- Thiamine pyrophosphokinase 1
- Mitochondrial thiamine pyrophosphate carrier
- Biotinidase
Sequence:
MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
Protein: Oxysterol-binding protein (D4A9D8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B
- Phosphatidylinositol-3-phosphatase SAC1
- StAR-related lipid transfer protein 3
- Membrane-associated phosphatidylinositol transfer protein 1
- Pleckstrin-2
- Motile sperm domain-containing protein 1
- Extended synaptotagmin-1
Sequence:
MAATELRGVVGPGPAAIAAPSGGGAGPPAVGGGGGRGDAGPGSGVAGATAATAGGPGPGAGGVAAGGPGSAPPAAGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGSTGSGKEQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQPASGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHVYRGEYWECKEKQDWGSCPDIF
Protein: Utp5p (A0A1D8PU59)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ribosome biosynthesis protein
- Nucleolar protein 58
- Utp9p
- Utp13p
- SnoRNA-binding rRNA-processing protein
- Nan1p
- rRNA-processing protein
- rRNA-processing endoribonuclease
- Nucleolar protein 56
- Utp8p
Sequence:
MSGPIICSKFDQSGNYLATGMVALDSHQVKVQSITSSQASLNTSFTLEKSNKLVNLAWIPSDSIQLLALCLSKGSILIYSPQTNEIVSELISSANVSILDFHYSTTTRTGWSCDIEGNVYEWDLNSYLLVDSFKVNEYIESVDSINRISTVMFNSQPHLLLGSNAVYLFNIKQRELVKTFPGHIQPVNSITALNNDMFLTSAKGDRFVNLYQLDKTATKAVFLGSSSVSSLSVSIKDDKSVLVIINEEGDIEIFNNPLADAKSQVSTPVPKKKRKQVGVSSRSFNASIKLSRPEPEIKSPQDTHLFINAVSTEDNLITFTWLENSTIPFFDTLKWIDETGSLLLESAKVLLKSKPNLKVTQHLTNGHDVAAPKLYTEGHTIVSDGSNIRDLEFQDHQEDEEDTEESLAEKLERLAMDQTSQQKSRRRKLEEARSGVSLSIVLTQSLKNNDQALLETVLSNRDPITIQNTISRLDPYSCVTFLDKLSEKIQRQPTRFDQVSFWLKWILVIHGPTMASLPNLSIKLSSLRAVLNKKAEELPRLLELQGRLKLMDDSAALRNEFSAEEIAEDLEERSDIEYNEEIDDAKYVGVISDDESMDDVDDFDDLDDEEEEEEEEEEDGIPDAANLDDREDSDLE
Protein: Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) (P58405)
Organism: Rattus norvegicus (Rat)
Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Striatin-interacting protein 1
- CTTNBP2 N-terminal like
- Striatin-4
- Striatin
- Cortactin-binding protein 2
- Programmed cell death protein 10
- Sarcolemmal membrane-associated protein
- Striatin interacting protein 2
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase 24
Sequence:
MDELAGGGGGQGMAVPPRPQQGPGGNLSLPPGANGAPGGGGPPAAETAGPPAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDAEAPPAQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSIEAKNLEQILNGGESPKQKGQEIKRPSGDVLETFNFLENADDSDEEENDMIEGIPEGKDKLRIHKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLMSKLKEQYKKERKGKRGAKRVNRTNLCDMITDLGDDELPHIPSGIINQSRSASTRMTDHEGSRAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDALRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNVDPYDTYESHVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKLPCICTYNGDKEHGIPTSVDFIGCDPAHMVTSFNTGSAIIYDLETSQSLVMLSSQVDSGLQSSNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHPSKAYIASAGADALAKVFV
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (ABC10-beta) (DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide) (RPC8) (O13877)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase III subunit rpc8
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerase I subunit rpa43
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit rpb4
- DNA-directed RNA polymerase I subunit rpa1
- DNA-directed RNA polymerases I and III subunit RPAC2
Sequence:
MIIPIRCFSCGKVIGDKWDTYLTLLQEDNTEGEALDKLGLQRYCCRRMILTHVDLIEKLLCYNPLSKQKNL
Protein: Microcin J25 (MccJ25) (Class II lasso peptide) (Ribosomally synthesized and post-translationally modified peptide) (RiPP) (Q9X2V7)
Organism: Escherichia coli
Function: Peptide antibiotic that functions through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP). Inhibits transcription by binding deep within RNAP secondary channel, where it sterically blocks the folding of the trigger loop, which is essential for efficient catalysis. In addition, it also seems to restrict access of nucleotide substrates to the catalytic center, and shows a partially competitive mode of inhibition with them. Exhibits potent bacteriocidal activity against a range of Enterobacteriaceae, including several pathogenic E.coli, Salmonella and Shigella strains. Also acts on the cytoplasmic membrane of Salmonella newport, producing alteration of membrane permeability and disruption of the subsequent gradient dissipation, which inhibits several processes essential for cell viability, such as oxygen consumption. Induces bacterial filamentation in susceptible cells in a non-SOS-dependent way, but this phenotype may result from impaired transcription of genes coding for cell division proteins.
Subcellular location: Secreted {ECO:0000305|PubMed:18632663}.
Interaction partners:
Sequence:
MIKHFHFNKLSSGKKNNVPSPAKGVIQIKKSASQLTKGGAGHVPEYFVGIGTPISFYG
Protein: 5'-nucleotidase (EC 3.1.3.5) (A0A0G2K097)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361276}.
Interaction partners:
Sequence:
MPTNQKFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYNGKRCPTCHNIIDNCKLVTDECRRKLLQLKEQYYAIEVDPVLTVEEKFPYMVEWYTKSHGLLIEQGIPKAKLKEIVADSDVMLKEGYENFFGKLQQHGIPVFIFSAGIGDVLEEVIRQAGVYHSNVKVVSNFMDFDENGVLKGFKGELIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGDLRMADGVANVEHILKIGYLNDRVDELLEKYMDSYDIVLVKEESLEVVNSILQKTL
Protein: Protein Wnt-10b (Protein Wnt-12) (P48614)
Organism: Mus musculus (Mouse)
Function: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:O00744}. Secreted {ECO:0000250|UniProtKB:O00744}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- Wnt inhibitory factor 1
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-1
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-2
- Glypican-3
- Frizzled-5
- Cerberus
Sequence:
MLEEPRSRPPPLGLAGLLFLALFSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKTFPISQPSPVPGSVPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAIGAALRERLSRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTLGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
Protein: Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4) (Q9UIA0)
Organism: Homo sapiens (Human)
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}.
Interaction partners:
- ADP-ribosylation factor 6
- ADP-ribosylation factor 1
- Interaction protein for cytohesin exchange factors 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- FERM domain-containing protein 4A
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Sequence:
MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ