wanglab/gogpt-training-data huggingface dataset:
Protein: Coronin-1B (Coronin-2) (Q9WUM3)
Organism: Mus musculus (Mouse)
Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BR76}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9BR76}. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. {ECO:0000250|UniProtKB:Q9BR76}.
Interaction partners:
- Coronin-1C
- Actin-related protein 2
- Hematopoietic lineage cell-specific protein
- Src substrate cortactin
- Rho GDP-dissociation inhibitor 1
Sequence:
MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEDWVSGQDANPILISLREAYVPSKQRDLKVSRRNVLSDSRPASYSRSGASTATAVTDVPSGNLAGAGEAGKLEEVMQELRALRMLVKEQGERISRLEEQLGRMENGDT
Protein: Protein Hikeshi (Q53FT3)
Organism: Homo sapiens (Human)
Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9DD02}. Cytoplasm, cytosol {ECO:0000269|PubMed:22541429}. Nucleus {ECO:0000269|PubMed:22541429}.
Interaction partners:
- Heat shock 70 kDa protein 4
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 1A
Sequence:
MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSMAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT
Protein: Nuclear hormone receptor family member fax-1 (G5EDJ0)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-ANGTCA-3'. Required for locomotion, neuron axon pathfinding, and regulation of expression of some peptide neurotransmitter precursors and of NMDA glutamate receptor genes. Involved in specifying interneuron identity, in concert with paired-like homeodomain unc-42. Plays a role in recognition of the PVPR and PVQL axons by the AVKR and HSNL growth cones.
Subcellular location: Nucleus {ECO:0000269|PubMed:10648229, ECO:0000269|PubMed:16183052}. Cell projection, axon {ECO:0000269|PubMed:10648229}. Cytoplasm {ECO:0000269|PubMed:10648229}.
Interaction partners:
- Homeobox protein unc-42
- LITAF domain-containing protein
- Peptide transporter 3
- NMDA-type ionotropic glutamate receptor NMR-2
Sequence:
MSDEDEPLNFSTSKATEESKEGILGVRSIFNTPLLFPPPMFNAGVISPHIAAALAMSFNQQRMNASVSPPLDHTTISVNSFPSMGSVKTDSPPTASSPTLCCAVCGDVSSGKHYGILACNGCSGFFKRSVRRRLIYRCQAGTGNCVVDKAHRNQCQACRLKKCLNKGMNKDAVQNERQPRNTATIRPALDMDPQNFFREYAGAVSAIMGHSNMMKREDSPSSASDGKTEDEKKDSLQETTMSQLESVLQWAQQFRLFTVLTNSEKRQIILTQWPRLLCISLCEQAEDVSFDDHLTSLMLKFRRLDVSPAEFNCLKAITIFMKRELSLWRAGWDNRASIITVYPAGERGARLVAAALLLAEHSVMGFGNCVIPLALVFSTKSRYVIQRHAINSLPACVPGGTSAHPVLRCSMGSRREKVI
Protein: 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) (P78812)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Interaction partners:
- Probable gluconokinase
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate 1-dehydrogenase gcd1
- Ribulose-phosphate 3-epimerase
- Probable 6-phosphogluconolactonase
- Ribose-5-phosphate isomerase
- Transaldolase
- Probable glucose-6-phosphate 1-dehydrogenase C7.13c
- Probable transketolase
- Glucose-6-phosphate isomerase
Sequence:
MSQKEVADFGLIGLAVMGQNLILNGADKGFTVCCYNRTTSRVDEFLANEAKGKSIVGAHSLEEFVSKLKKPRVCILLVKAGKPVDYLIEGLAPLLEKGDIIVDGGNSHYPDTTRRCEELAKKGILFVGSGVSGGEEGARYGPSLMPGGNPAAWPRIKPIFQTLAAKAGNNEPCCDWVGEQGAGHYVKMVHNGIEYGDMQLICETYDIMKRGLGMSCDEIADVFEKWNTGKLDSFLIEITRDVLRYKADDGKPLVEKILDAAGQKGTGKWTAQNALEMGTPVSLITEAVFARCLSSLKSERVRASKKLTGPNTKFTGDKKQLIDDLEDALYASKIISYAQGFMLMREAAKEYGWKLNNAGIALMWRGGCIIRSVFLKDITEAFREDPNLESILFHPFFTNGVEKAQAGWRRVVAQAAMLGIPVPATSTGLSFYDGYRSAVLPANLLQAQRDYFGAHTFRVLPEAADKSLPADKDIHINWTGHGGNISATTYDA
Protein: Xylan O-acetyltransferase 13 (EC 2.3.1.-) (Protein trichome birefringence-like 1) (OsTBL1) (Q2QYU2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan. Catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:29569182}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MWSALFSHLREVHKRSGVKEEKLIMKSPPAAGEAGCHKPQATATNKMTVLQSPLGLRTILTSLVAFFIVVSSVSLLFDRGQDAQAQLAVEQHQHQEVLLKQKPASAAVGEQKSVVVDQSSLRSQEAQVQWTSELQDVATDSGDGGFDGEEDCNWSLGRWVYDNASRPLYSGLKCSFIFDEVACDKYGRNDTKYQHWRWQPHGCNLPRFNATKFLEKLRNKRLVFVGDSVNRNQWVSMVCMVEHFIPDGRKMRVYNGSLISFKAFEYNATIDFYWSPLLLESNSDNPIIHRVEYRIIRADRIEKHANVWKDADFIVFNSYLWWRKQRDGMMMKVMYGSFEDGDAKLDEVQMVDGYEIALKKLTEYLGANINKNKTRIFFAGSSPAHSWASNWGGDDNNKCLNETEPIQIEDYRSATTDYGMMDKAKEIFGTLEPKGIHVQILNITQLSEYRKDAHPTIFRRQYVPLTKEQIANPSIYADCTHWCLPGVPDVWNEFLYAYIMHK
Protein: Serine/threonine-protein kinase dkf-2 (EC 2.7.11.13) (D kinase family-2) (O45818)
Organism: Caenorhabditis elegans
Function: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17728253}. Membrane {ECO:0000269|PubMed:17728253}. Note=Translocation to the cell membrane is required for kinase activation. {ECO:0000269|PubMed:17728253}.
Interaction partners:
- Serine/threonine-protein kinase dkf-1
Sequence:
MDANDYPRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSESEKSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSRRVSANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSGIHKKSIAVEGTEIALRDLRNEALQFIKEIYPEKGCSSLEDYILLYKHDLRSINILQLITTSSDVTDGTLVEVVIGSCPQNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYHKRCASKIPNNCNGSKQRRPSAIPLSPSNSNILNLNERRHSRRESCLEALDAARPSSTLGGAATPNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVPHTFQVHSYKLPTVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGNTKASQFFLGSQADDGASEDRDDDLSLRSGSGAHKKAQNTPSAPLQGSEGSGSPGPVVSFAANALSNMPDDDVISSESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGITMYQDENTTRYYKEIPLNEILNVSMSPPDKTADYLFEIRTGVCVYFISGSPSDEKGSSLDAQSWTTAIQSALMPVTPQSSVVGGKRIDKLKVPTEGETGHLGAKIQTEHEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSSEKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQIWMQNYTLWSDLRVLEKAVGQRFVTHESDDVRWQAYEKEHNVTPVYV
Protein: Inner dynein arm I1 intermediate chain IC97 (C7A2A8)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Interaction partners:
Sequence:
MAPKDAAKGKKKKKTKEELEEERRQAEEAARLAEEERLRAEEAERQRLAELERQRLELLGQFLDAEKARLDAQLSELDPLLRQFEHERSRSRAAAREAAEWERFLRCVDVPHPRQRVPLAEFLRRMHEAATKDVTGSPDGRDLRAAFLAVEACRTVILEARQELLAARHSSELAAPPAAAAAAAGGGGGASAEEAQAAAGSAARGAAGGAAVAEWAEALESDLRTLYGIVNARIDRLTAAVLHHCDEYANDKNEIQLGHVAPMPAWWPTAPGSGSGSAGSQQQQQGGGGEQQQLAEGAGEGPGGAFKWGVWVNTAKNPRLKAVEMPQLGVTLEIPKQIALANIALRVQQRSGPGVDEYFSRCANAWMAVGGLLAVDLLAMPPGAKKVRGWTLRQVTPLALNVQRVPYPIPPAGADPATWASEEEPPPLGVTAPLPPDVVLLEDPLQVAWWDEAHSIWNTDGISDVAFDGASKTFSFHTTHLAPLALVMRRTRLLPYAGWAVRPTGGRNGNGAAISLDVGLDAPVVIEVSKGAAWLSSPAWPQLASLIGQPMPPLDLLQALSDRGLHLLPEDRDAEAAGVTAKARDTEEAMCRDLALLGGVFLMASSRWNQTAGPEEALARLSEVTDWEEGGRTAPHHLARIFDKEKEDGERRVLVVMRRGAKGVAFSDALNRRPEYPALPGVGSVEAVKECELSIWGEVHASVLTLLRGQFSAPGAADSPLALRLAAAPESLELCRTTSPLFTATLADTMLALRLFSFS
Protein: HTH-type transcriptional regulator ArgP (Inhibitor of chromosome initiation) (OriC replication inhibitor) (P0A8S1)
Organism: Escherichia coli (strain K12)
Function: Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, dapB, dapD, lysA, gdhA and argK. Acts by binding directly to their promoter or control region. ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector. Both arginine and lysine are coeffectors at the argO promoter, but only arginine is competent to activate transcription. Lysine has repressive effects. ArgP also mediates lysine repression of dapB, and gdhA in vivo, but via an alternative mechanism: ArgP binding is directly reduced upon the addition of lysine. Binds in vitro to the promoter region of dnaA and to the upstream region of the nrd promoter, but these genes are probably not regulated by ArgP in vivo. In vitro, binds also to the three 13-mers located in the origin region (oriC) and blocks the initiation of replication.
Interaction partners:
- Arginine exporter protein ArgO
- 2-hydroxy-3-oxopropionate reductase
- 2-hydroxy-3-oxopropionate reductase
- Chromosomal replication initiator protein DnaA
Sequence:
MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVSSKPFAEKYFPNGVTRSALLKAPVVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELIDLTPGLFQRRMLYWHRFAPESRMMRKVTDALLDYGHKVLRQD
Protein: Large ribosomal subunit protein uL6z/uL6y (60S ribosomal protein L9-1) (P49209)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL28z
- Large ribosomal subunit protein eL39z/eL39x
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL18z
Sequence:
MKTILSSETMDIPDSVTIKVHAKVIEVEGPRGKLVRDFKHLNLDFQLIKDPETGKKKLKIDSWFGTRKTSASIRTALSHVDNLISGVTRGFRYKMRFVYAHFPINASIGGDGKSIEIRNFLGEKKVRKVEMLDGVTIVRSEKVKDEIVLDGNDIELVSRSCALINQKCHVKKKDIRKFLDGIYVSEKSKIVEEE
Protein: Methyltransferase OMS1, mitochondrial (EC 2.1.1.-) (OXA1 multicopy suppressor 1) (Q06668)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial methyltransferase which suppresses respiratory defects caused by OXA1 mutations when overexpressed.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15355998, ECO:0000269|PubMed:16823961}; Single-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15355998, ECO:0000269|PubMed:16823961}.
Interaction partners:
- Adaptin medium chain homolog APM2
- Ribosome assembly protein RSM22
- mRNA-binding protein PUF3
- ATP-dependent rRNA helicase SPB4
Sequence:
MIVFRRFPTCLLHHIRQPASRSLLLESQRRSLSFTSYKYNSSHIDDDKSKKKLKNVFQMNSNRVIRKQKTKEELAKERFEEQLRSPNRFVRWGAIARSEKFSKGMTKYMIGAYVIFLIYGLFFTKKLFAKDKELERLLKKQEEGNANEYEALRIKELKGKLRRRDELKLEEYKKMQEEGIENFDDIRVQNFDQNKLNEQILPARDTTNFYQEKANEYDKAINMEERVIFLGKRRKWLMKHCQGDVLEVSCGTGRNIKYLDMSRINSITFLDSSENMMEITHKKFREKFPKYKKVAFVVGKAENLVDLAEKGKPSLENEKENQVKYDTIVEAFGLCSHEDPVKALNNFGKLLKPDGRIILLEHGRGQYDFINKILDNRAERRLNTWGCRWNLDLGEVLDDSDLELVEEKRTHLGTTWCIVAKRKGDVKKKDELGFVEKYLQSSIRKRMESFEKKDDMASKKELEPVPPVSKS
Protein: C3H1-type domain-containing protein (G2HJZ1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSDSGYSAPRRRLHHQFEHLGSEQQQQQQQQTPAPKIVYPSMQVVNIEMATGDGPKRSDNHHYHHHHHQRRHIPAPPSTGPLSSLIDQADYEASMASGKMFGKPENIRTYGAMIRANEEHVERNQTGVVKKERATVLPKRDLSLIREEDTLLVDGSHLNMTSSAILPAHQIPSTTTTSTSSPVQEQPWYEKIFGKMTMIQEESSMGGEDDDAHEDHYSR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q95SW3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
LTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSATNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWLR
Protein: Battenin (Q8SXL8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Interaction partners:
Sequence:
MTATKQQEAEAEHDPQVVVTPGDASRSSRQDRGLWRDLTSYWILGLCNNYGYVVMLSAAHDIIKQFNPNDESEESSSGRNCHLVSTGAILLADVLPSLFVKILMPFFPFWVNFRIALAVAFSAAGFLLVGFANAEWMALLGVIITSASSGIGETTFLAYSSRYNKNVISTWSSGTGGAGVIGSLSYASLRSLDFSPRDTMLVMLIFPAIEAFAFWLLLRRPQVDILPVTTVESTEVLISDEKPLVGFKEKLFYIKHLFKYMLPLCLVYFFEYFINQGLFELVYFEDIFLDKDSQYRWLNVDYQIGVFISRSSVNLFQLDKIWLMSIFQFVNVVYFLTEVIWWYTPSIWIVFAIVLWEGLLGGGAYVNTFYRMSKEISPERQQFAMAMVVQSDSYGIALAGFLAIPVHNAICGLPAAARSLVW
Protein: Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (M9PEL6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEDRTDTEPVLLSKHAKNLLRFLNLLPARMASHDNTRSTIVFFAVCGLDVLNSLHLVPPQLRQDIIDWIYGGLVVPRDNEKNCGGFMGCRAMVPKTEDAEILECMRNYQWGHLAMTYTSLAVLVTLGDDLSRLDRKSIVDGVAAVQKPEGSFSACIDGSEDDMRFVYCAATICYMLDYWGDVNKETMFQFITRSLRYDYGFSQELEGEAHGGTTFCALAALHLSGQLHRLDATTVERMKRWLIFRQMDGFQGRPNKPVDTCYSFWIGASLCILDGFELTDYARNREFILSTQDKLIGGFAKWPQATPDPFHTYLGLCGLAFTGEPGLSPVNPSLNMSMAAYAHLQHLHEQWRSADGRGDEDISHNDGKPHKARGES
Protein: Vacuolar morphogenesis protein 10 (Q08474)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for vacuolar fusion. Involved in the early steps of the fusion pathway.
Subcellular location: Vacuole membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Ammonia regulation of amino acid uptake protein
- Antisense of depressing factor protein 1
Sequence:
MLFEVFGEVLASYIVSSKTKGELAFPVNNAPPDSLVAINCVVLFLRSAIGSCSGAKELIRSSALELSCSSSCGLPATDKPGSFHSGALSKSILSANEAVVSKSSLSFLSSFVDI
Protein: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form] (O77836)
Organism: Bos taurus (Bovine)
Function: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2}.; SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]: Secreted {ECO:0000305|PubMed:9565571}.
Interaction partners:
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-
- alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
- MGAT4 family member D
- MGAT4B protein
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Sequence:
MRLRNGTVATVLAFITSFLTLSWYTTWQNGKEKVIAYQREFLALKERLRIAEHRISQRSSELSAIVQQFKRVEAETNRSKDPVNKFSDDTLKILKELTSKKSLQVPSIYYHLPHLLQNEGSLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGETDTDYVNGVVANLEKEFSKEISSGLVEIISPPESYYPDLTNLKETFGDSKERVRWRTKQNLDYCFLMMYAQEKGTYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMFQAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQHVGLHSSLTGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWAITPVAGDYILFKFDKPVNVESYLFHSGNQDHPGDILLNTTVEVLPLKSEGLDISKETKDKRLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKVTN
Protein: Dynamin-related protein 3A (Dynamin-like protein 2) (Dynamin-like protein 2a) (Q8S944)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the control of mitochondrial and peroxisomal division and morphology. In association with PEX11C, PEX11D, PEX11E and FIS1B, is involved in cell cycle-associated constitutive self-replication of preexisting peroxisomes.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14988495}. Peroxisome {ECO:0000269|PubMed:18539750, ECO:0000269|PubMed:20179140}.
Interaction partners:
- Mitochondrial fission 1 protein A
- Mitochondrial fission 1 protein B
- Dynamin
- Mitochondrial fission protein ELM1
- Peroxisomal and mitochondrial division factor 1
- Probable transmembrane GTPase FZO-like, chloroplastic
- Uncharacterized protein T22P22_20.
- Peroxisomal membrane protein 11E
- Peroxisomal membrane protein 11B
- Aminopeptidase M1
Sequence:
MTIEEVSGETPPSTPPSSSTPSPSSSTTNAAPLGSSVIPIVNKLQDIFAQLGSQSTIALPQVVVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLVLQLLQTKSRANGGSDDEWGEFRHLPETRFYDFSEIRREIEAETNRLVGENKGVADTQIRLKISSPNVLNITLVDLPGITKVPVGDQPSDIEARIRTMILSYIKQDTCLILAVTPANTDLANSDALQIASIVDPDGHRTIGVITKLDIMDKGTDARKLLLGNVVPLRLGYVGVVNRCQEDILLNRTVKEALLAEEKFFRSHPVYHGLADRLGVPQLAKKLNQILVQHIKVLLPDLKSRISNALVATAKEHQSYGELTESRAGQGALLLNFLSKYCEAYSSLLEGKSEEMSTSELSGGARIHYIFQSIFVKSLEEVDPCEDLTDDDIRTAIQNATGPRSALFVPDVPFEVLVRRQISRLLDPSLQCARFIFEELIKISHRCMMNELQRFPVLRKRMDEVIGDFLREGLEPSEAMIGDIIDMEMDYINTSHPNFIGGTKAVEAAMHQVKSSRIPHPVARPKDTVEPDRTSSSTSQVKSRSFLGRQANGIVTDQGVVSADAEKAQPAANASDTRWGIPSIFRGGDTRAVTKDSLLNKPFSEAVEDMSHNLSMIYLKEPPAVLRPTETHSEQEAVEIQITKLLLRSYYDIVRKNIEDSVPKAIMHFLVNHTKRELHNVFIKKLYRENLFEEMLQEPDEIAVKRKRTQETLHVLQQAYRTLDELPLEADSVSAGMSKHQELLTSSKYSTSSSYSASPSTTRRSRRAGDQHQNGYGF
Protein: GH07253p (Slow termination of phototransduction, isoform B) (Slow termination of phototransduction, isoform C) (Q7KRT4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDYIFECFFDDTFEQISRNGLQDRQSRRDVLDHLSSIIKGCSGGQNSQTDEVAAIAVTAAMRYHRMAKEQNGQVCLMGKYHNILYIGLRTCWDWGVRDSEVVVKLLVAIYECEKTYERIFLGALFGPHAPHFIAGWRSDFQDQHENVRAMVYFLKHATREQLTLPVWIPRFEQERQLRFIDVPIESCGKSSPLRIALQANAPELLLILLRYGAAPQPPDGGASVIIALLDKLIEDGRNYSFELVMCLKILLRNVVMIEMPFKPLLYAARREMFFDRYGRLLMDKIIGKEQVYGVPSLRHLCRCCIRDVMRMHNQLPSGIDTLRLPKRLQRYIDLTEELEGPEAQDTEDKDQQRGKSSAKCKMGSEMGRLDTISSAGESEDESENQAQLLQAVTDPEKAALAAFMATGDGAYTEEAKKAAVEAYVAACPPDFDPDFPPISLPGEPR
Protein: C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299) (Q9H2X3)
Organism: Homo sapiens (Human)
Function: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted {ECO:0000305}.
Interaction partners:
- CD209 antigen
- Intercellular adhesion molecule 3
- Angiotensin-converting enzyme 2
- Inter-alpha-trypsin inhibitor heavy chain H4
- Transforming protein RhoA
- Kinase suppressor of Ras 1
- Lymphocyte-specific protein 1
- Rho guanine nucleotide exchange factor 12
- Serine/threonine-protein kinase PLK3
- Stabilin-2
Sequence:
MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE
Protein: 60S ribosomal protein L36 (Q8I713)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 60S ribosomal protein L28
- 60S ribosomal protein L14, putative
- Ribosomal protein L37
- 60S ribosomal protein L6, putative
- Ubiquitin-60S ribosomal protein L40
- 60S ribosomal protein L21
- 60S ribosomal protein L2
- 60S ribosomal protein L24, putative
- Ribosomal protein L15
- 40S ribosomal protein S15A, putative
Sequence:
MGRKSTIKPATGIAVGFNSGHVVTKRNLKLHKKKKPFSKRKELIKDVVREITGFSPYEKRIIELIKIGTSASTKRSLKYAKKKLGTHKRGKAKREEIQKVVILQRRKAAEKH
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q9XZ61)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Proteasomal ubiquitin receptor ADRM1 homolog
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory complex subunit p50
Sequence:
MGDGAGNWCLIESDPGVFTELIREFGCDGAQVEEIWSLDSESFKNLEPIHGLIFLFKWVQEDEPAGKVVLDRENIFFAKQVINNACATQAILSLLMNLDHEDIKLGETLTNFKEFCQCFDPYNKGLTLSNASQIRTVHNSFARPTLFELDTKNQKKDDDVYHFVGYMPIGGRLYELDGLREGPIDLGEIKSEQNWIDVVRPIIEKRMQRYSDGEIHFNLMALISDRQRIYEQQIEKLLNPAPNAMDTEEDRQAEISSLRTYIEYEIQKKKRYKVENVRRKHNYLPFIVELLKILGENGQLMPIYEKAKQRALEREQAQRKKDTD
Protein: Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) (Q2TBJ5)
Organism: Rattus norvegicus (Rat)
Function: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250}.
Interaction partners:
- Ubiquitin-like-conjugating enzyme ATG3
- Autophagy protein 5
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy-related protein 16-1
- Ubiquitin-like-conjugating enzyme ATG10
- Mitochondrial antiviral-signaling protein
- WD repeat domain phosphoinositide-interacting protein 2
- Protein Atg16l2
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor-associated protein-like 1
Sequence:
MAEDPEAVLQLPAAPAAAAGESLLELSPETAIPEPPSSVAVSPGTEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTVQALIDFIRKFLRLLASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG