wanglab/gogpt-training-data huggingface dataset:
Protein: G-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37) (Q8TDU6)
Organism: Homo sapiens (Human)
Function: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12524422}; Multi-pass membrane protein {ECO:0000269|PubMed:12524422}.
Interaction partners:
- Bile acid receptor
- Guanine nucleotide-binding protein G
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2
- NCK-interacting protein with SH3 domain
- Type II iodothyronine deiodinase
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 5-like protein
- Chemokine XC receptor 1
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
Protein: Protein lin-25 (Abnormal cell lineage protein 25) (Q10573)
Organism: Caenorhabditis elegans
Function: Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types. Positively regulates the fate of vulval precursor cells. Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation.
Subcellular location: Nucleus {ECO:0000269|PubMed:9806929}. Cytoplasm {ECO:0000269|PubMed:9806929}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 23
- EOR-2
- ETS domain-containing protein
- EOR-1
Sequence:
MNSIKIDSSTKIVIEYIDKLRNCSNEKRQKVSSVIRPVDFPGISTQQLCDILIRFAYNGTYIDDVFRDHLLKLVVDKSITWNQVIHSVINTKTDRIYSKCLQCELIREMVNYVQIKSFSDKLHADELISIMKPTVFFLAQLIQDVLSDEDELEMIQIEYGDVRKAYYKPLEALSAFIHDDLCSSLLAFSEASEITHQLELCRDSFSKLRSPDKSATTLVEMLIERHIEKCKPVKFQYIPEGIALFDLKNPSIRILIPIFACFKNHESSKLMAETIQTFAEIMRFYGPDVIFDILHGAILLKCEESMDLLHFPKQHRADFRWQSTTFFYKKLPQIIEYLIRSEKLTVAEVQFGLEKALTDLSMMFDAADVAWQNASFLTLLNELEPVLGKTITDPLRLRRREHMKTNDQLLPFADTDNQLIENTDIDKLLNAVKEVMNLQFGQTEEFSKLFVDKVKTGQTDNFDAITSILITEGRLMEVGKAFVLKNVEAQRSSAVGVNERIQIFDDTFILLSRILIKNPSVSINMFVNGGPGKSDAEQTMFYKWSMRYVKRVAKHRDPEPKDETEYIALRKEVEMLMRLANAEVGIEDDLENDVEEEMPEVQEPNIETQNVDEISIPDPLHLLIENDPTVTAESKETEEVKFNPEGVEQMDTNEKPAEISDSLIEPTLLEEPKDILENIIVPIIKVEAPKPDSPIKKKKDPDVTWHEVHCPLPRISRRTARAYLAQMKEGIPFWKTDDPNLNIGSILAAIPRLGQLLVDEHEEKRNRIDRKSAEENMTNILHAIESMPSLFLCLLEWLDCEPESGARTSLAFTINLSLERYLAVSTHGINYMKWIFIKSTVQQMIDELVDKSPAFPEVTCTAFSTARRFCPFVGRNENPDQLKLKHAWYYMRQQAWASPHALRLLEHANTAREYDVWSHIYISKTIKSGCGDIMTSSVDMIFSFLMLDDLNSIIRIHESLMAFWLSEDAGQCQADGRFDPLSIRVVIRLMTQVLLIAEWTLDRLLNEDPAFVERLNLKEVKAPEPEDPDKREKWIFLLRSMLERTINRFFKIVRKGLLSNVVNTIIQLLKSIAGSADCKAKRLLVKRIPPDLIFQLAYIEPSSVDYSLMNIYCDPDNKEHTQTKIMFLCALRRSQSFSF
Protein: exo-alpha-sialidase (EC 3.2.1.18) (Q4V9A4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEKQLGSKARHFPVTTVFKQDPQKSEGTQVTYRIPALIYNGENKTFLAFAEKRKTTDDTDADVLVMRRGIWRDGVVEWDMTHECLSSASLPNHRSMNPCPVYERESKTLFLFFITVPVGVSEHKQIKENKNQARLCYITSKDTGKTWSAVTDLTADVIGEQEKNWATFAVGPGHGIQMKSGRLIIPAYTYYFTSGTSPTSHAFAFYSDDKGSTWHIGKCVDGESNECQMAEIIDDDGNSKLYCNARNRSGYRNEALSESKGKDFKSSSVRKLTDTGNGCQGSVLSFAPDHTSEKTWLLYCHPADKRKRMSLGVYLNKCPSDLSGWGSPVILHEGPSGYSDLTQCGDGKHFACLMECGEKSELERIGFVLFEHKEVI
Protein: Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (LAP) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) (Q68FS4)
Organism: Rattus norvegicus (Rat)
Function: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme (By similarity). For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates (By similarity). Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12675513}.
Interaction partners:
- Aminopeptidase N
- Glutathione hydrolase 6
- Glutathione hydrolase 7
- Glutathione hydrolase 5 proenzyme
- Gamma-glutamylcyclotransferase
- Putative glutathione-specific gamma-glutamylcyclotransferase 2
- Glutathione synthetase
- Glutathione-specific gamma-glutamylcyclotransferase 1
- Glutamate--cysteine ligase regulatory subunit
- Prolyl 4-hydroxylase subunit alpha-1
Sequence:
MYLLPLPAAARVALRRLGVRGLWDRGLSTADMTKGLVLGIYSKDKDDDVPQFTSAGENFNKLVSGRLREMLNISGPPLKAGKTRTFYGLHQDFPSVVVVGLGKRSAGVDDQENWHEGKENIRAAVAAGCRQVQDLELPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKVAVSAKLHGSGDLEAWEKGVLFASGQNLARQLMESPANEMTPTRFAEVIEKNLKSASSKTEVHIRTKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYTGSPNATEAPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADVNNLGKYRSAGACTAAAFLREFVTHTKWAHLDIAGVMTNKDEIPYLRKGMSGRPTRTLIEFLLRFSKDSS
Protein: Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) (Cytochrome c oxidase subunit VIA*) (P12075)
Organism: Rattus norvegicus (Rat)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00428}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00428}; Matrix side {ECO:0000250|UniProtKB:P00428}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 6C-2
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 7B, mitochondrial
Sequence:
MASRLLRGVGALAAQALRAHGPRGVAATRSMASGGGVPTDEEQATGLEREIMIAAQRGLDPYNMLPPKAASGTKEDPNLVPSVSNKRIVGCICEEDNCTVIWFWLHQGESQRCPNCGTHYKLVPYQMVH
Protein: RNA polymerase II degradation factor-like protein (DUF1296) (Q8VZT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit delta, chloroplastic
- ATP synthase subunit O, mitochondrial
- ATPase, F1 complex, OSCP/delta subunit protein
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit 9
- Pyridoxal 5'-phosphate synthase PDX1-like 4
- Pentatricopeptide repeat-containing protein At1g03100
- ATP synthase subunit delta', mitochondrial
Sequence:
MSSSKVGGGARKGIQDIPSGSRKIVQSLTEIVNSPEAEIYAMLKECNMDPNETVSRLLSQDPFHEVKSKKEKKKETRDISDSRPRGANNTYNRGARGGSARYAGRSGSTHFSSTDSGNFQGKSTNKKESGTQGYTSSWSSASGVANTYQTPHSEPVATENKLPPVTLGDGISSSQSASGHQTAWFGAPGQRSMAEVVKMGRPQNKTTKQNVNMGSEINHEHKVSANHQAPVKDEWPSIEKPLAPSTSSLSVAPAESEVRNGPADFQSDRGDQYLKDRLENIHIAESGPSESRKVDHVQADSVQEDESVVSSEIDDNPYQTQSHPVEHHKDEDDVSSGSASFQQLDSHDQEVSHEKDRPAVVIPNHLLIHTEECAQLSFGSFGGFGSRPLSNSVEATSDVAPQIEHSDARNTEFYGDEHLGSTTNGNMVHTPATGNYDDSLETRREVLKQENSEGAQEHQYTFTQSEQGYAYENAKQQQMNSAYDASHTNSQNQMHNLDSLSNVMQGYSHSVPNTLLAQTAQNARELDFQYSPFSAQQSMQSRTSNNASSLGGQSISMPEALRGSGIPATQPTQQTLPGANIATGPALPQQLPMHYSQPTLPLTHYANMIGYPLMPQNYPYMPSAFQQTFAGNSAYHQQLAALLPQYKTNVSPGNLPQSATAPASAYGFGNSTNVGSAGNFPLNQQSATTGTTLGYDDVLSSQYKENHLLALQQQQQQQQHQQQNENSAMWHQGHGSRTMSGVPTNTYYNLQAQQQLQLQHQQQQQQAQQAAGGYRQAQQQQHYGSHGYPNYYQSQTEMSLERQQQNPRDGAGSQAGQPSNQSQQQLWQNSY
Protein: Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste) (P42124)
Organism: Drosophila melanogaster (Fruit fly)
Function: Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
Subcellular location: Nucleus {ECO:0000269|PubMed:9012527, ECO:0000305|PubMed:22354997}. Chromosome {ECO:0000269|PubMed:22354997}.
Interaction partners:
- Polycomb protein esc
- Polycomb protein esc
- Polycomb protein Su
- Chromatin assembly factor 1 p55 subunit
- Polycomb group protein Pc
- Histone deacetylase HDAC1
- E3 ubiquitin-protein ligase RING1
- Polycomb protein PHO
- Polycomb group protein Psc
- Zinc finger protein jing
Sequence:
MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV
Protein: LD12131p (Q95RT8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKRSIQCRSNTRRFVNADGNREGSDSESISGRNMNGQDDDYDGMGPLQEEYDEDDGLLVEDNQPEEQGSPSNRQYLDESEQQYVQLSDYDDQHLLVENAVDAEDGGEDLDELLTEDQYFNAVQQHHQQHQQHHGRGQDYNDELIYEITLKTEDN
Protein: Chaperone protein DnaJ, putative (Q57WJ9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKKESVPSKSENTTDLQPEGVDMPGEPLDVIGRAFSNRQPKHIGQGLADAVRNVAVGLGVGISSFIALPIAGGKREGATGVAKGIGFGLLGLAGGAAAGLVTGARQLGRGVVNTKAAVEETIRRERYWCSITGGWIEVRLNEMLADIPVTDDDIYCKAREEYRKVSSSSWDGAASPSGSEGNDPSEEGCEGSCGKEDYYSLIGVERTATTSQIRAAFHRKALTLHPDKNTGDAEATQRFQAILEAYNVLSNDAQRSEYDARGSVDINAGEGGLTSPIEQSLGATQLEPFIGRVEWAVHLTPYVYFDSELRKELKKRRVLRLAQNLVRFVDGDESTLESVRPLIIDAVSTRGGARLMPVVAQQYAAAARQHLTSSSLLREVDNFGTSKLAFLGGVADATVACLTTAVKAARKRLDGDEFLDTVLALCECDVQKNVLRAARLLFYDLSASAEQRNTRAYNLLKLSNMIKDICLSCSSVVIEAQ
Protein: Corticotropin releasing hormone (G1KSW8)
Organism: Anolis carolinensis (Green anole) (American chameleon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Corticotropin releasing hormone receptor 2
- Corticotropin-releasing factor receptor 1
- Corticotropin-releasing factor domain-containing protein
- Corticotropin-releasing factor-binding protein
- Uncharacterized protein
- Pro-thyrotropin-releasing hormone
- Neuropeptide Y
- Parathyroid hormone/parathyroid hormone-related peptide receptor
Sequence:
MKIQLLVSTGVVLLALLPGCHECRALSKGLPVAPAPDSSASQPSDFPDQLPPSLPVLLRMGEEYFLRLGSLRKNPASSSSSSSSSSSLSSTSSSSHLAATGNFLRAAAQQLHQLQQLQERSLGGAAAIAAVAAAEQPWEEGGGAPEGAHAGEAPPKEKRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
Protein: Borealin (Aurora borealis protein) (Borealin-related) (Q9VLD6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of embryonic mitosis. The CPC complex has essential functions at the centromere for ensuring sister chromatid cohesion, recruitment of the CPC to kinetochores, and chromosome alignment and segregation. There is no function in meiotic histone phosphorylation or spindle formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16224046}. Chromosome, centromere {ECO:0000269|PubMed:16224046}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16224046}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with and is required for the correct localization of the CPC components Aurora B kinase and Incenp in mitotic cells. Is absent from spermatocytes undergoing meiosis.
Interaction partners:
- Inner centromere protein, isoform A
- Aurora kinase B
- Deterin
- Kinesin-like protein
- Bub1-related kinase
- Aurora kinase
- ATP synthase subunit alpha, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit a
- ATP synthase F
Sequence:
MPRTKIPKNSKRNREVANREEKVRLYELKMDSRLISIDSLETKFLSAVDHQVKTLLGQVQKELANLKMPEVLRLFEELDRFSDFKASDQTQLLASMSMSGSAIEGHAPSATGSRNDEEDSSIGASGGSILAAHTGSLLRSTKAMRTPGPLHSARARRARRSRSACGDLNILHSAKPPSISSSSSSSRNSRSKLRTPMASRAKAFSADRTPLKQKQMRSGSPTTPPMAFLRYPKPGEVALSKYGSPMVAQVMPDKFANVNIPIRNGVLSLRPKKLDADEVESNLLENLDEDTLNQIKTLHENLQMIVNKASQAVFK
Protein: Dehydrogenase/reductase (SDR family) member 3a (Dhrs3a protein) (Short-chain dehydrogenase/reductase 3a) (Q6DBS5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cytochrome P450 26A1
- Aldehyde dehydrogenase 1 family member A3
- Aldehyde dehydrogenase 1 family, member A2
- Beta-carotene oxygenase 1.
- O-acyltransferase
- Lecithin retinol acyltransferase b, tandem duplicate 1.
- Lecithin retinol acyltransferase a
- Dehydrogenase/reductase
- Inactive all-trans-retinol 13,14-reductase
- All-trans-retinol 13,14-reductase
Sequence:
MEMKVLGCALLFPFQIVFSILKATVRFFTRQKRRDLGTDVVLITGGGRGIGRHLAKEFAKQGARKVILWGRTEKCLKETCEEISMTGTECHYFVCDVGNREEVYQQAKVLREKVGDVTILVNNAAVVHGKSLMESDDDALLKTQHINTLGQFWTTKAFLPRMLELCNGHVVCINSILSLSSIPGAIDYCTSKASSYAFMESLTLGLLDCPGVGCTTVLPFHTDTEMFQGMRVRFPKLFPPLNPEMVAERTVDAVRTNTAFVVLPWTMHFLVILKSLLPQSALEEIHKFSGSYTCMNTFKGRT
Protein: Candida glabrata strain CBS138 chromosome D complete sequence (Q6FWB8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- adenosylmethionine decarboxylase
- Ornithine decarboxylase
- S-methyl-5'-thioadenosine phosphorylase
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- Saccharopine dehydrogenase [NADP
- Arginase
- Dihydrofolate reductase
Sequence:
MSEITHPTIVDGWFREISDTMWPGQAMTLKVEKVLHHEKSKYQDVLIFKSTNYGNVLVLDNVIQATERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHECVEEAWLCDIDEAVIRLSKEYLPDMAGVYSHPKVKTHIGDGFQFLRDYQNTFDVIITDSSDPEGPAETLFQQSYFELLRSALTDKGVITTQAESMWLHLPIIKDLKKACSQVFPVAEYAYTTIPTYPSGTIGFMVCSKDASANVKKPLREMTEEQEKKLLRYYNKRIHESSFVLPTWVAKELEL
Protein: Uncharacterized membrane protein C21C3.06 (Q9P7L7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAFDKLANVATVDAIFAISSSTFLWSTWVLQRTILKRPNFFSPNPVVEKMVHPTLITWKLFSFTSVLTVSTFTFASCLIMRTIGVENIKEFGLYAREKLSFARAKPVKDDITSFPNHKISIT
Protein: Transmembrane 7 superfamily member 3 (Seven span transmembrane protein) (Q9NS93)
Organism: Homo sapiens (Human)
Function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10828615}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISSNVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPVQNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFETTIKFAPANLGYARGVDPPPCDAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRMVSVPQVKASALKVVTLTANDKTSVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTLFALLGFFICFFGHRFWKTELFFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTPLGNLKIFHDDGVFWVTFSCIAILIPVVFMGCLRILNILTCGVIGSYSVVLAIDSYWSTSLSYITLNVLKRALNKDFHRAFTNVPFQTNDFIILAVWGMLAVSGITLQIRRERGRPFFPPHPYKLWKQERERRVTNILDPSYHIPPLRERLYGRLTQIKGLFQKEQPAGERTPLLL
Protein: Protein ALEX (Alternative gene product encoded by XL-exon) (P84996)
Organism: Homo sapiens (Human)
Function: May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.
Subcellular location: Cell membrane; Peripheral membrane protein. Cell projection, ruffle {ECO:0000250}. Note=Predominantly associated with cell membrane ruffles. {ECO:0000250}.
Interaction partners:
Sequence:
MMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHWSSLDSPVGSMQALRPSAQHSWSPEPSVVPDQAWEDTALHQKKLCPLSLTSLPREAAVNFSYRSQTLLQEAQVLQGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLSLMEKDLGTTAHPRGFPELSHKSTAAASSRQSRPRVRSASLPPRTRLPSGSQAPSAAHPKRLSDLLLTSRAAAPGWRSPDPRSRLAAPPLGSTTLPSTWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQQRWKEPLMPRREEKYPLRGTDPLPPGQPQRIPLPGQPLQPQPILTPGQPQKIPTPGQHQPILTPGHSQPIPTPGQPLPPQPIPTPGRPLTPQPIPTPGRPLTPQPIQMPGRPLRLPPPLRLLRPGQPMSPQLRQTQGLPLPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLPIRLLRGLLARLPGGASPRAAAAAACTTMKGWPAATMTPAETSPTMGPPDASAGFSIGEIAAAESPSATYSATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPRSAQRRNAVSSSTNNSRTKRWATCVRTACCF
Protein: Calcium-binding EF-hand domain-containing protein (Q54HC2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Myosin IC heavy chain
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Ras GTPase-activating-like protein gapA
Sequence:
MNHINTKAQVIEAFKVFDRDGNGYVTVDYLRKVLNELGDMMPADEIEEMIYEADPQNSGYVQYETFVGMLFLWD
Protein: Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1) (Q8N8N7)
Organism: Homo sapiens (Human)
Function: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
Sequence:
MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
Protein: At3g19990 (E3 ubiquitin-protein ligase) (Q501F4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGSSSSPSPNDAVLESARPFLRGELEKIDPKLPSLIAVLKSVGAGECWHKHGSFLDHLIDIYKILKLWKAPESVCLCGLFHSAYSNSYVNLAIFDPSTGRDVVRDHVGEAAESLIHLFCVVPRQTLIHDELLFKYSDCELVEHLDCSEVSLRNAKEKGIFDGDEEWRKKINALVPENGVVVKHIKTGEEIVVSRRVVGVFLLMTMADFSDQLFGFQDELFCNHDGRLEFRGNNVTALWPGNGKPGLWMNSNSRMGAIYSLIVREEEILMEERRRAFGSGFEVRKERDEDIDLVVPPVFSFCTKVLDAKEQIEAREMYWEVVSSDTSKEGYLERAEERLLGCIEKNPFVGEPHVLLSQVYLGKKRFKEAEREAEKGLLLLLQWGSPWDKRMSWEGWIAWVRVLLMKSQDQSWPDVSWGILNLGLVR
Protein: DExH-box ATP-dependent RNA helicase DExH8 (EC 3.6.4.13) (Zinc finger CCCH domain-containing protein 31) (AtC3H31) (EC 3.6.4.12) (O22243)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AP-2 complex subunit sigma
- AP-2 complex subunit mu
- Calcium sensing receptor, chloroplastic
- Protein NUCLEOLAR COMPLEX ASSOCIATED 4
- At4g01000
- F18K10.11 protein
Sequence:
MAVSSPTSSSSSSESLPLPSSNFASLPIMAMKRRIIDKILENRVTLIVGEPGCGKSSQVPQFLLEANMAPILCTQPRRFAVVAVAKMVAKSRNSDLGGEIGYHIGHSKILTEGSKILFKTAGVLLDEMLDKGLNALKYKVIILDEVHERSVESDLVLVCVKQFLMKNNDLRVVLMSATADITRYRDYFKELGRGERVEVVAIPSPDQRTIFQRRVLYLEQVAGLLGVSSDLSAYCPGPSPSSADTEIKPELQNLIHDLILYIHEKEPDIEKSILVFLPTYYSLEQQYHQLEPFFASFEVHILHRSIDTEQALAAMKICRSRRKVILATNIAESSVTIPKVAYVIDSCRSLQVFWDPSRKRDAVQLVWVSRSQAEQRRGRTGRTCDGEVYRLVPSAFFNKLEEHEPPSILKLSLRQQVLHICCTESRAINDANALLAKAMDPPDPDVVDDALRMLLSIQALRKSPRGRYEPTFYGRLLASFPLSFDASILVVKFGEMGMLRQGILLGVLMDTLPLPIHHPFGDDSLFLEYVDHYFGGSKTISGGRREMVLMANFCAFQFWQRVFKDKHRLENLKQLLSKEKDKDLKLMFPEIEKEWCDFHNIAQSSFYHVSELYEDTLSSFHRFRPQFISSSDSQPTYYNPYEFDHTCYIECQPSEDKYLHSEDVDNNQPPPEVRKCVSVPFVPPNAFQANAIAENMASIIKEIRTQCTPSESDNGHGALEPEDYVEYGEAPVCVYFLNGYCNRGGQCTFTHTLQSTRPACKFFASSQGCRNGESCLFSHAMRRRTTSYLPPPQCLPEEDGSSTSPLLDLFPTSSEGCILVFDDSDMHFTSSIANRYPSWRILSTSSSSETLFCDSSLADTRIFWGLNHPYQTIISKAGRENPIPWNEVKCVLWFLNPDSYADTPEKQKTILQNFFEHMAIRLLGDKLYKIRVVLTMNNVRFSLLQVEKLARESFFFLGESFPHDSESFGAFQDTLTIQKPMLVSRPISYVFNLHPPSDIQFGNYTSLLRKSLHNK