wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 41 (Q9P7N3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for vacuolar assembly and vacuolar traffic.
Interaction partners:
- Vacuolar morphogenesis protein 6
- Vacuolar membrane protein pep3
- Probable vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 33
- E3 ubiquitin-protein ligase pep5
- Vacuolar protein sorting-associated protein 3
- Vacuolar fusion protein mon1
- Vesicle transport v-SNARE protein vti1
- Synaptobrevin homolog ykt6
- Ypt/Rab-type GTPase ypt7
Sequence:
MSVDESNSDSEIDSISSSDEDEEPKLIYERITEKFQGCFMNDTISACAISKEHFFFGSHNGAIYIYQKNGILLRKMILHSASVVDLSVDLESENLASCSMDGKMIISNITTRETTVHDFKRPLLSVAIDPYYSTRSSRQVLSGGRAGKVVLSEKGWLGNKDTVLQADCGAVYKISWYTTYIAWASDLGITVYSTEFGKVLGRLEPPKRLPNDEIFPYQLFWQSESRLVIGWSDQIMIVSIQRSNVANELPKISLQALLEIDSIVSGVLMLGFNILTLAYIANVEDFTSAIPSQRIEGCRPELRLIDSSFKELCGDAIGLANYSRLQPSDYHLLPDPSSNSHSFVISPNDIVYVRERNQIDHVKYLVSKEMYAEAIDAVKKLPEIPPSLQISELAKKYIFHLLGKGQYKEAGMVIPSLYNDNLAEWEQWVFVFAENDHLEDIADFLPTGENHLSPLVYEMILAQYLATDERTFNKKLHEWPTMLYSVSTIRNATLKKFKENQKSSTLTESLAFLYLEDNMPIDAFHLYLKLHSELCIDLILQHNLYDEARASVLLLMLISSKGKSSDTKSAMSSMLVQHVHSFPPQEVIMQIHSVPQFLYEYFCEFELMYPNSLMEYGDLKLDVFAEFDRKRFFDFLVNTQCYSLDHAAQICKQYNYLDELVYILGRMGNNKEALMLIINELLDIGRAIRYVKEQADRELWDDLISYSLDKPEFICTLLENIGTDENARNLLSKIPPGTKLPHMKKSISKLLADHQSQVQLYQSCYKLFKNESISMAIKYREQEQSGLEFLVKDNPFNSFGDEQLDYNYRKRIPMIYDLRTKKYIRPEDVRIDTDDVFKDDKIAYFKTRMHLKPEVQMRNKLDLLMMLYKQT
Protein: Protein snwA (P54705)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase cypE
- Crooked neck-like protein 1
- Protein BUD31 homolog
- Pre-mRNA-splicing factor SYF1
- Cell division cycle 5-like protein
- WD40 repeat-containing protein
- 116 kDa U5 small nuclear ribonucleoprotein component
- Activating signal cointegrator 1 complex subunit 3-like
- WD40 repeat-containing protein
- Pre-mRNA-processing-splicing factor 8 homolog
Sequence:
MTSLSSLLPKPKNVYSNEEEDPLFQPKPKPQQQKQQQQQQQELNDKPKKVIPTYGNRKGYLPKNIEDFGDGGAFPEIHIVQYPLDMGRKGKSKSSNSNTSNMNGGGTTTSIVPVSVDSTGRVKHEAILGEKGSLHSQYKDLIPKQHTEHELQRPDDDELQETLDRTKNALEKIVNGKIKSSKSTNYVEVEKKSATYIKYTPSNQLGSNNGSALNSKIVRMVDVAQDPLEPPKYKIKKKIMEHGSPPAPVMHSPTRKLSVQDQQDWTIPPCVSNWKNPKGFAISIDKRLVSNGGGLQDVEINDKFAHFTQALYIAESNAREEVSARAELERKLAQKEKERKQDMLRKLAEDVRNERSGIIQQRYTRKDNSDSDNDNDNDSSSDEDKNKRTPPMNRRSRSRSTERIPSRNDNDDDDDRYRIKDNRDNRGRDNIDSRDNRDSRDSRDSRDSRDSRDSRDSRDNRDSRDSRDNRDNRDNRRRDDSNDRDRYSKRRSDSDSDSDSDSSDSEDERVRRERKEKLERDKIRMEKKRELEREYRLEASGKKSKFNRDQDRDISEKIALGQASIKRTEDSIYDQRLFNQSESLTSGFGNDDSYNVYSKPLFGGAVSNSIYRPKSNQEDNTSIQDVLSNSRFGKEGGSGSGGVPRPNKEFSGTDRSKDRTGPVAFEKEKKKSDDPFGFDDFSKKR
Protein: Cystatin (Q98967)
Organism: Oncorhynchus keta (Chum salmon) (Salmo keta)
Function: Cysteine proteinase inhibitor.
Subcellular location: Secreted {ECO:0000269|PubMed:8902609}.
Interaction partners:
Sequence:
MEWKIVVPLLAVAFTVANAGLVGGPMDANMNDQGTRDALQFAVVEHNKKTNDMFVRQVAKVVNAQKQVVSGMKYIFTVQMGRTPCRKGGVEKICSVHKDPQMAVPYKCTFEVWSRPWMSDIQMVKNQCES
Protein: Uncharacterized protein (Q9TXM1)
Organism: Caenorhabditis elegans
Interaction partners:
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
- Guanyl-specific ribonuclease pgl-1
- Guanyl-specific ribonuclease pgl-3
- HTH OST-type domain-containing protein
- Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
- Protein meg-1
- ATP-dependent RNA helicase glh-1
- Protein meg-2
- Zinc finger protein mex-5
- HTH OST-type domain-containing protein
Sequence:
MSSSKPYPSGLPNSRRKRGGRRSSSRSNQESASNNMEHQITLDELFNPIAKQDSAQSTSREYGAKSGISHHGSVSFNGNTFMNGQQLNHSMTRHGRVFNQSMHAAQGNGSNAFNSIPPTAPVFSADFRRNLQTRNSSSWYERRFPVSTDQDDVQQSNTRRSRSRQNGQHGLSFSDGSNNYGHAGNKSFSVSSVPVGFQKQENNSKKLRQTNVHQQCLGNKSFNAQAGVHGHAFKKGHKDNKNASGKEVINSSLVQKHDAIKSRNLNQSFSGFPTHETSSMKNQQQKSRNDRKKSRGSSNFQDRTYFNTNDDELTDDVFIDDSMDAARGRRSRSVTKKLQQSTYSKQNAGSKQLTEKCKSSEEAAKRNLVSNVFSKDGTELSIEQLLEIVSMKIGQQIHLPSSSHGECSNLNRTLPASDLNCSIGEDFDSSFVDANNQTLPVSLPKKTSLSIKRRGSSRSASRLASLDVTLETVEEDEEPTPSPQPSSPPKISRRKWTGTFDANVEEMRRLLHGDPEMPKSANRASSSKDQINRNNVDVKRTPSSSIIPTPKALIGERCLTSSSKSSKLNKSLGVVDSKATKSPMYSVTVSGKETASGKRIAQKLTPKVVALESSYITGIPVSTDCNGCPTPKRSGINCEIRAAEVYNQAGKWPFEITSDPAPLPCESADRIEYPSQDCTQDPASTSPPPRISESLTAFLEAQQDFNDYIDTNYKEKTQLLKVNLNIHGMSPERWLYLNYFCTETIPRLDGPYADDPRVPPVRNMFRKWFLRFAEACLGNPHQLAVMQEIAATFVQARLDDTSSSTDSTNMLYMLWKECIGQKNIIAIADACLLAHLRKSDPIKYLNVKRDWLESIFDPPRDQ
Protein: Serum response factor homolog (Uncoordinated protein 120) (Q18955)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Regulates myogenesis, in cooperation with transcription factors hlh-1 and hnd-1. Required for maintenance of muscle in adulthood.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:29314608}.
Interaction partners:
- Hand transcription factor 1
- ETS domain-containing protein
- SAP domain-containing protein
- Putative iroquois-class homeodomain protein irx-1
- Transcription factor elt-2
- Forkhead box protein fkh-2
- Transcription factor elt-1
- T-box transcription factor tbx-8
- Serine/threonine-protein kinase sgk-1
- Homeobox protein pal-1
Sequence:
MTEAEDFAQLLQKLQNASPALPEGTSSTPTPSSSTGLLPNGKKTKGRVKIKMEYINNKLRRYTTFSKRKTGIMKKAFELSTLTGTQVMLLVASETGHVYTYATPKLQPMISSDTGKAMIQSCLNAPGGDGSDVQPSRTEFTFDSGNGGNGMRKRKMLSDVMSAESSNNSPSMPNFTPFLAPSMAPLFSTFGEDDYNNDESGDDSDSEEASSDIKEEYQGSPTMVKQETTEIDSVTASLQQRIKEAMRQAASNKQAIKKAKITPPSSNMNNAAFLNPFLLQGGANASNLLATAARKGDDAGSLTSNPFLSMGLNLQQLIESAAIASNE
Protein: Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Q9VYI3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q13405}.
Interaction partners:
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein bL19m
- Ribosomal protein
- Large ribosomal subunit protein mL51
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein uS9m
Sequence:
MATSAKLMLGSGLCQKLSQLTRQIHMQPALMSSFRSSREVQELDKYPEVEVVANPPEWRFVERLLPAKTVPQPVEKPKYPSGWQPQKEDGSELGYHVARTKNHMVPVYLHTRFRGQRRITVVRRVQGDIWTLEKDLRAVVEQSRNGKVCATRINELSGQIHFHGDHVDVLRDYLKEKGF
Protein: Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) (O43490)
Organism: Homo sapiens (Human)
Function: May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Subcellular location: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
Interaction partners:
- Hematopoietic progenitor cell antigen CD34
- Cadherin-related family member 1
- Signal transducer CD24
- CD44 antigen
- Transcription factor SOX-2
- Aldehyde dehydrogenase 1A1
- Catenin beta-1
- Epithelial cell adhesion molecule
- POU domain, class 5, transcription factor 1
- Homeobox protein NANOG
Sequence:
MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH
Protein: E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) (Q2Q1W2)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:24239284}.
Interaction partners:
- Protein argonaute-2
- Calpain-3
- Gamma-butyrobetaine dioxygenase
- Protein lin-28 homolog A
- Protein lin-28 homolog B
- Zinc finger protein 362
Sequence:
MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF
Protein: Collagen alpha-1(XXVII) chain (Q5QNQ9)
Organism: Mus musculus (Mouse)
Function: Plays a role during the calcification of cartilage and the transition of cartilage to bone.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793, ECO:0000269|PubMed:17693149}. Note=Found on some small banded collagen fibrils and filamentous meshworks.
Interaction partners:
- Collagen type V alpha 3 chain
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Lumican
- Collagen alpha-1
Sequence:
MGTGFARGARGTAASGPGGGFLFAWILVSFTCHLASTQGAPEDVDVLQRLGLSWTKAGGGRSPTPPGVIPFPSGFIFTQRAKLQAPTANVLPTTLGRELALVLSLCSHRVNHAFLFAIRSRKHKLQLGLQFLPGRTIIHLGPRQSVAFDLDVHDGRWHHLALELRGRTVTMVTACGQHRVPVPLPSRRDSMLDPQGSFLLGKVNPRAVQFEGALCQFSIHPVAQVAHNYCAHLRERCRQVDTYSPQVGTLFPWDSGPAFALHPEPALLGLGNLTRTPATLGARPVSRALAVTLAPAMPTKPLRTVHPDVSEHSSSQTPLSPAKQSARKTPSPSSSASLANSTRVYRPAAAQPRQITTTSPTKRSPTKPSVSPLSVTPMKSPHATQKTGVPSFTKPVPPTQKPAPFTSYLAPSKASSPTVRPVQKTFMTPRPPVPSPQPLRPTTGLSKKFTNPTVAKSKSKTTSWASKPVLARSSVPKTLQQTVLSQSPVSYLGSQTLAPALPPLGVGNPRTMPPTRDSALTPAGSKKFTGRETSKKTRQKSSPRKPEPLSPGKSARDASPRDLTTKPSRPSTPALVLAPAYLLSSSPQPTSSSFPFFHLLGPTPFPMLMGPPGSKGDCGLPGPPGLPGLPGSPGARGPRGPPGPYGNPGPPGPPGAKGQKGDPGLSPGQAHDGAKGNMGLPGLSGNPGPLGRKGHKGHPGAAGHPGEQGQPGPEGSPGAKGYPGRQGFPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGEMGRPGFPGDFGERGPPGLDGNPGEIGLPGPPGVLGLIGDTGALGPVGYPGPKGMKGLMGGVGEPGLKGDKGEQGVPGVSGDPGFQGDKGSHGLPGLPGGRGKPGPLGKAGDKGSLGFPGPPGPEGFPGDIGPPGDNGPEGMKGKPGARGLPGPPGQLGPEGDEGPMGPPGVPGLEGQPGRKGFPGRPGLDGSKGEPGDPGRPGPVGEQGLMGFIGLVGEPGIVGEKGDRGVMGPPGAPGPKGSMGHPGTPGGIGNPGEPGPWGPPGSRGLPGMRGAKGHRGPRGPDGPAGEQGSKGLKGRVGPRGRPGQPGQQGAAGERGHSGAKGFLGIPGPSGPPGAKGLPGEPGSQGPQGPVGPPGEMGPKGPPGAVGEPGLPGDSGMKGDLGPLGPPGEQGLIGQRGEPGLEGDHGPVGPDGLKGDRGDPGPDGEHGEKGQEGLKGEDGSPGPPGITGVPGREGKPGKQGEKGQRGAKGAKGHQGYLGEMGIPGEPGPPGTPGPKGSRGTLGPTGAPGRMGAQGEPGLAGYNGHKGITGPLGPPGPKGEKGDQGEDGKTEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGEPGQQGQPGHPGPRGRPGPKGSKGEEGPKGKPGKAGPSGRRGTQGLQGLPGPRGVVGRQGPEGTAGSDGIPGRDGRPGYQGDQGNDGDPGPVGPAGRRGNPGVAGLPGAQGPPGFKGESGLPGQLGPPGKRGTEGGTGLPGNQGEPGSKGQPGDSGEMGFPGVAGLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIIGPPGMLGPSGLPGPKGDRGSRGDLGLQGPRGPPGPRGRPGPPGPPWHPIQFQQDDLGAAFQTWMDAQGAVRSEGYSYPDQLALDQGGEIFKTLHYLSNLIQSIKTPLGTKENPARVCRDLMDCEQRMADGTYWVDPNLGCSSDTIEVSCNFTQGGQTCLKPITASKAEFAVSRVQMNFLHLLSSEGTQHITIHCLNMTVWQEGPGRSSARQAVRFRAWNGQVFEAGGQFRPEVSMDGCKVHDGRWHQTLFTFRTQDPQQLPIVSVDNLPPVSSGKQYRLEVGPACFL
Protein: BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (P0CF95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (By similarity). Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A0JNT9}. Note=Localizes around the centrosome. {ECO:0000250|UniProtKB:A0JNT9}.
Interaction partners:
- Actin related protein 1, centractin
- Bicaudal D homolog 2
- BICD cargo adaptor 2.
- Dynactin 5.
- Dynactin 4.
- Hook microtubule tethering protein 3.
- Dynactin subunit 2
- F-actin-capping protein subunit beta
- Actin-related protein 10
- Coiled-coil domain-containing protein 125
Sequence:
MSASCLDLISAPPQPDSDRMDRALNPGRQNSPDTAGELTLLHTAPGGLGMALEEELAMLTGDREDELQESAPETPVSGQDSDLLSLFRQKEKDLVLAAKLGKALLERNQDLTKQYDKMTKDLNDRLELLEQEKHELRRRLESREGEWEGRVAELETDVQHLQGELERHQLQLRDADREKSRAISELSEQNHRLLEQLSRAAEVEKQLSTQVHSLRDDFKEKSISSNQHMTRLETLQAEIRMLSERKQDLERRVCAVLEENQQLQNTVEELRERTLELEKHCHHKDLQKILPETLLTIIKLKTNYSQKKKKTEHLILHTRRAHTHLCRAPSEVQSCMGSLSCVWCIQRRKDCDLFLLQLRLQLWEAYCQVRSICSQLRGNDITDSALSTDSSMDESSETLSAKDVPTGSLHSSLLELRRLTQNLLDGNESTVALLSVEVSSSREENERLRAMTEVHEPNEQLQSAIRDRDEAIAKKKAVEMELAKCKIDIMSLNSBQLLDAIQQKLNLSQQLEAWQDDMHRVIDQQLMDKHQEEWKDPPFSFSRRGAAASRPTQRLADRDKPLFSFFKKN
Protein: Nucleobindin 2a (Nucleobindin-2a precursor) (Q7ZUY4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSCLKGLLTSCLVLASVLSWAQAVPISIDKTKVKIPEETVKEPPQSVDTGLHYDRYLREVIDFLEKDQHFREKLHNTDMEDIKQGKLAEELDFVSHHVRSKLDELKRQEVSRLRTLIKAKQDIEGGNDIAVDHQALLKQFEYLNHMNPHTFEVEDLDRLIKSATKDLENYDKERHEEFKKYEMMKEHERREHLKTLDEDGRKKEEEHYEEMKKKHADHPKVNHPGSKDQLKEVWEEADGLDPEDFDPKTFFNLHDTNGDGFFDEQELESLFTKELEKIYDPTNEEDDMVEMEEERLRMREHVMNEVDSNKDRLVSLDEFLVATKKKEFLEPDSWETLEQNQAYTEEEMREFEEQLVRQEEDLNQKAADLQKQREDLERQQEQLNAQKIELQQAVEHMERIKTQKVPPPSEILEGNAVPESVGQDQPPVPLEHQPLPPGHQDVPPPAAQQHHDELQNQQALGQEHQNTPHENQPLPPGHNNPPEDPPLVPLDHNIVP
Protein: Protein RecA (Recombinase A) (P16971)
Organism: Bacillus subtilis (strain 168)
Function: Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single-stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Hydrolysis of ATP in the presence of single-stranded DNA is partially inhibited by RecU. Required for DNA transformation; protects transforming DNA from degradation, possibly in combination with DprA.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:16061691}. Note=Protein is diffuse with an occasional discrete spot in the absence of DNA damage (PubMed:32117122). Following H(2)O(2) treatment, RecA forms filamentous 'threads' in vivo which may correspond to in vivo RecA-ssDNA filaments (PubMed:32117122). 'Thread' formation is maximal by 40 minutes and then dissipates; in the absence of rarA very few 'threads' are formed (PubMed:32117122). Protein is recruited to RC foci following DNA damage (PubMed:16061691). During competence a number of proteins (at least CoiA, ComFA, ComGA, DprA, RecA and SsbB) are thought to colocalize at the cell pole (PubMed:17630974). {ECO:0000269|PubMed:16061691, ECO:0000269|PubMed:17630974, ECO:0000269|PubMed:32117122}.
Interaction partners:
- LexA repressor
- DNA polymerase I
- DNA processing protein DprA
- Regulatory protein RecX
- DNA repair protein RadA
- Probable ATP-dependent DNA helicase RecS
- DNA gyrase subunit B
- ATP-dependent DNA helicase PcrA
- DNA repair protein RecN
- ATP-dependent DNA helicase RecQ
Sequence:
MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLALDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYAQKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDSHVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSSVRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLGTELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQQQAEETQEELEFEE
Protein: Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) (Q9Z239)
Organism: Mus musculus (Mouse)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.
Interaction partners:
- FXYD domain-containing ion transport regulator 4
- cAMP-dependent protein kinase catalytic subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha-1
- cAMP-dependent protein kinase catalytic subunit beta
- Sodium/potassium-transporting ATPase subunit alpha-2
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit beta-3
- Sodium/potassium-transporting ATPase subunit alpha-4
Sequence:
MASPGHILALCVCLLSMASAEAPQEPDPFTYDYHTLRIGGLTIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSSRRR
Protein: Homeobox protein bagpipe (Homeobox protein NK-3) (P22809)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the determination of cell fates in the dorsal mesoderm.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Forkhead box protein biniou
- Myocyte-specific enhancer factor 2
Sequence:
MLNMESAGVSAAMAGLSKSLTTPFSINDILTRSNPETRRMSSVDSEPEPEKLKPSSDRERSISKSPPLCCRDLGLYKLTQPKEIQPSARQPSNYLQYYAAAMDNNNHHHQATGTSNSSAADYMQRKLAYFGSTLAAPLDMRRCTSNDSDCDSPPPLSSSPSESPLSHDGSGLSRKKRSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLRLTETQVKIWFQNRRYKTKRKQIQQHEAALLGASKRVPVQVLVREDGSTTYAHMAAPGAGHGLDPALINIYRHQLQLAYGGLPLPQMQMPFPYFYPQHKVPQPIPPPTQSSSFVTASSASSSPVPIPIPGAVRPQRTPCPSPNGQMMSVESGAESVHSAAEDVDENVEID
Protein: Protein kinase C and casein kinase substrate in neurons 3 (Syndapin III) (Q5I2Z0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAPEEDAGGEVLVGSFWEAGNYRRTVQRVEDGHRLCGDLISCFQERARIEKAYAQQLADWARKWRGAVEKGPQYGTLEKAWHAFFTAAERLSELHLEVREKLHGPDSERVRTWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHTARKDEKTAQTRESHAKADSSMSQEQLRKLQERVGRCTKEAEKMKTQYEQTLAELNRYTPRYMEDMEQAFESCQAAERQRLLFFKDVLLTLHQHLDLSSSDKFHELHRDLQRGIEDASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRAISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPSSPGSGQDEDWSDEESPRKAGTGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA
Protein: POU domain, class 5, transcription factor 2 (Sperm 1 POU domain transcription factor) (SPRM-1) (Q9DAC9)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530}.
Interaction partners:
Sequence:
MAGRRSSNVFPLSGNSGGGLEVDTPTWLSSQAATSRLMVRPSMGPGICPGPEVWGVPLGSSPYEFRGGIAPYRACEARAWSQSSSEDTCPGPYIALRYMPNLALPEDVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVDEKNLLGICRMEMILEQARKRRRASRERRIGSNLEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNRSQMGSWPTNDTSRREDVGATGSPFPGPPVCFPMAPGLHFDFTHYEGSCLTPLYSSTPFPVRGALLSAPTTTLGLPRLSS
Protein: MRG/MORF4L binding protein (RE02355p) (Q7K003)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- NuA4 complex subunit EAF3 homolog
- Transcription-associated protein 1
- Enhancer of polycomb-like protein
- Inhibitor of growth protein
- Chromatin modification-related protein MEAF6
- Brahma associated protein 55kD
- YEATS domain-containing protein 4
- Bromodomain containing 8
- Protein male-specific lethal-3
Sequence:
MMAKDKGLAVAGTAAPLPAALDHEWSAEEELQLFHAMEGLRPVGINKHFYMSCIVQRLSKSLNREMPSELIWRHLGTMYKLKELDDLESLPFPNEEREFSLPEQDYGTLQTKKTVEVHANEEAAEAQSAPPTAETNGKAPPATKTPVPTNSTKDGDKKPVAKPQEQLPKRPAKRTRGSMSNESISPSTTPPPVQSNKRRRI
Protein: MLO-like protein 12 (AtMlo12) (AtMlo18) (O80961)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Oleosin 20.3 kDa
- Ubiquitin-conjugating enzyme E2 32
- BRISC and BRCA1-A complex member 2
- AT3G21215 protein
- At5g57910
Sequence:
MAIKERSLEETPTWAVAVVCFVLLFISIMIEYFLHFIGHWFKKKHKKALSEALEKVKAELMLLGFISLLLVVLQTPVSEICIPRNIAATWHPCSNHQEIAKYGKDYIDDGRKILEDFDSNDFYSPRRNLATKGYDKCAEKGKVALVSAYGIHQLHIFIFVLAVFHVLYCIITYALGKTKMKKWKSWERETKTIEYQYANDPERFRFARDTSFGRRHLNIWSKSTFTLWITCFFRQFFGSVTKVDYLTLRHGFIMAHLPAGSAARFDFQKYIERSLEQDFTVVVGISPLIWCIAVLFILTNTHGWDSYLWLPFLPLIVILIVGAKLQMIISKLGLRIQEKGDVVKGAPVVEPGDDLFWFGRPRFILFLIHLVLFTNAFQLAFFVWSTYEFTLKNCFHHKTEDIAIRITMGVLIQVLCSYITLPLYALVTQMGTSMRPTIFNDRVANALKKWHHTAKKQTKHGHSGSNTPHSSRPTTPTHGMSPVHLLHNYNNRSLDQQTSFTASPSPPRFSDYSGQGHGHQHFFDPESQNHSYQREITDSEFSNSHHPQVDMASPVREEKEIVEHVKVDLSEFTFKK