wanglab/gogpt-training-data huggingface dataset:
Protein: HTH-type transcriptional regulator YjiE (Hypochlorite-response regulator protein YjiE) (Quorum-sensing regulator protein D) (P39376)
Organism: Escherichia coli (strain K12)
Function: Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study.
Interaction partners:
- RCS-specific HTH-type transcriptional activator RclR
- HTH-type transcriptional activator AaeR
- HTH-type transcriptional repressor NemR
- HTH-type transcriptional regulator XapR
- 33 kDa chaperonin
- HTH-type transcriptional regulator TdcA
- Inner membrane protein YjiG
Sequence:
MDDCGAILHNIETKWLYDFLTLEKCRNFSQAAVSRNVSQPAFSRRIRALEQAIGVELFNRQVTPLQLSEQGKIFHSQIRHLLQQLESNLAELRGGSDYAQRKIKIAAAHSLSLGLLPSIISQMPPLFTWAIEAIDVDEAVDKLREGQSDCIFSFHDEDLLEAPFDHIRLFESQLFPVCASDEHGEALFNLAQPHFPLLNYSRNSYMGRLINRTLTRHSELSFSTFFVSSMSELLKQVALDGCGIAWLPEYAIQQEIRSGKLVVLNRDELVIPIQAYAYRMNTRMNPVAERFWRELRELEIVLS
Protein: Aspartate aminotransferase, cytoplasmic isozyme 1 (EC 2.6.1.1) (Transaminase A) (P46645)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Important for the metabolism of amino acids and Krebs-cycle related organic acids. Involved in plant nitrogen metabolism of Asp and Asp-derived amino acids and in the synthesis of Asp/Asn for seed storage. May be involved in the assessment of the pyridoxal phosphate levels in the cell.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Asparagine synthetase 2
- 4-hydroxyphenylpyruvate dioxygenase
- Asparagine synthetase 3
- Asparagine synthetase 1
- L-lactate dehydrogenase
- Arogenate dehydrogenase 1, chloroplastic
- Arogenate dehydrogenase 2, chloroplastic
- Isoaspartyl peptidase/L-asparaginase 1
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 2
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial
Sequence:
MDSVFSNVARAPEDPILGVTVAYNNDPSPVKINLGVGAYRTEEGKPLVLDVVRKAEQQLVNDPSRVKEYIPIVGISDFNKLSAKLILGADSPAITESRVTTVQCLSGTGSLRVGAEFLKTHYHQSVIYIPKPTWGNHPKVFNLAGLSVEYFRYYDPATRGLDFKGLLEDLGAAPSGAIVLLHACAHNPTGVDPTSEQWEQIRQLMRSKSLLPFFDSAYQGFASGSLDTDAQSVRTFVADGGECLIAQSYAKNMGLYGERVGALSIVCKSADVASKVESQVKLVVRPMYSSPPIHGASIVATILKSSDMYNNWTIELKEMADRIKSMRQQLFEAIQARGTPGDWSHIIKQIGMFTFTGLNKEQVEFMTKEFHIYMTSDGRISMAGLSSKTVPHLADAMHAAVTRLG
Protein: PfEMP1 variant 1 of strain MC (Q25733)
Organism: Plasmodium falciparum (malaria parasite P. falciparum)
Interaction partners:
Sequence:
MGGGNGGGGTKDKDAKHALDRIGEEVYKEKVENDAEKYKKALKGNLQEAKGIGELASSPNPCKLVEDYYNNRLKRKRYPCANRQTVRFSDEYGGQCTFNRIKDSENNDNSIGACAPYRRLHLCDYNLEKMGKTSTTKHDLLLDVCMAAKYEGDSIKTHYTKHELTNPDTKSQLCTILARSFADIGDIVRGKDLYLGYDDKEKDERKKLENNLIEIFKKIHENLGTQDAKDHYKKDEENYYQLREDWWTANRSTVWKAITCHAGESDKYFRKTCCSGEWTDDKCRCKDEEGKNETNEVPTYFDYVPQYLRWFEEWAEDFCRKRKKKIENAIKNCRGEKGNERYCDLNGYNCEETARGAEIFVKGDDCHKCSVACDRFVKWIDNQRKEFDKQKKKYDEEINKTHGTTITTGNGKINNLYVGHFYKILKKYYPTVDKSLQKLNDEAICKKPPNVGNEKASTVDFNNEVNTTFSHTTYCEACPWCGAQKEKNGGGWKAKEKSCAKKKERIFNKENSTDIKILTPEKGRSKTLEKLKTFCKDGQKIKNDIWKCHYDDNGTDDQTDDSNDCVLGDWGNLTKEDKIMSYNAFFWMWVHDMLIDSIKWRDEHGRCINKDKGKTCIKGCNKKCICFQKWVEQKKTEWGKIKDHFRKQKDIPKDWTHDDFLQTLLMKDLLLEIIQDTYGDANEIKRIEALLEQAGVGGIDFAALAGLYTKGFVAEKDTTIDKLLQHEQKEADKCLKTHTDDTCPPQEDRSVARSESATVPSPPADPKATEEVDANASSDDEDDFEEEEEEEEDEGEEEAEEVQEEKTDESATEAVAPSPPGTTQDGVKPASQEDDVKVCSIVDKALKGKLDDACTLKYGKTAPTSWKCIPSGNNTTTESTTKPGAAGTPSGKDTGSICVPPRRRKLYVGKLHDWAGGETTEAKSQETSGGQKTPSGNESSPSEKLPQGPTPETTKETPESSLLHAFVSPPRLRRFLPWHKFKEQWKAQHGAGATGQQTIIGTLDGGGEETPDKLLKTGHIPPDFLRQMFYTLGDYRDILVGNTDIVVHTSGNKEDMQIMEAIQKKIEQILPTSGSSPSPPRVTQTQHSVENPRKTWWNENGKKIWEGMVCALTYNTDTPSGTAPTQIQEVRTKLRDENSKNPKIPQYKYDQVKLDDTSDAKTTGSPVPSGEKITPLTDFISRPPYFRYLEEWGETFCKERKKRLEKIKEECRGDRTGHEHCSGDGYDCTRTDADRNDKFVDLNCRDCHIQCRKYRKWIDIKFDEYHKQEKKYQGEYDKLTKDKSSGGDNNCCKDIEKHKSAAVFLKELKHCKNGQTSENKGNQEDQLNKLDFDKIPQTFSPSTYCKACPVYGVNCNGNKRGRGGTNGCTTNNEPENKENDKGAASTISILINDGSTNGATNGTTGTTDETLKECSDKYAFFKGLRKQEWTCQKKYGVNQCNLTNRVNDTYFDKDIVFNEFFQRWLRYFVHDYNILKHKIDPCIKKEKQDKTEHKCINGCNIKCECVRKWLEIKGNEWGNIKKHYNINSNDDKETIAYNVKSYFVDQGLFDTDYKKAQKVVEDEKERKKIWGCTGHDECSEKEKEENKNFITNLISELQDKITSCQNKHNPNGKTACDPFPSPTPEETDPLDDDTPDPLDDDQHTEQPKFCPPPPPPMTCVEKIAKELRVEAEGKINNELKGNGKDFNGKCNNVKKKNGAVIGEESCKFEQTYENSVNNINNKCKDNQNERFKIGQKWNFKYIGTIRKDLCIPPRREHMCLDDLSMLGRTTISDSSALLKKIQEAAKSERDDIIRKLLEQNSCDEHRICDAMKYSFADLGDIIRGRDLWNKNSKQKGLQKRLEYAFINIYNKLQNDKNKYEKDRPKYLQLRSDWWDANRKHIWNAMTCNAPDDAKFLKKNPNDTSGSSSSKGIMTTHSNCGYDKEPPDYDYIPQPFRWMQEWSESFCKLLNEEMEQFEKTCGECKKNSITCEDDRNGTNCENCKNQCEKYKKLIHNWKLGFDKYKEIYNEIYNNKDSKINSNEYFKKFLEKLKDKCKELNSSDKCIDEATHCTKYKFSNSENKNHNNYAFKNPPKEYEKACKCDAPDPLDNCPKDSATYEKACNTLLPTKLCESKTFNNDDDSWDTSFVQTSPRDNTGVLVPPRRRQICLKNITTKLRSIEKIDDFKAELMTSAYNEGKLLCELYKKDRDVTLQAMKYSFYDYGDIVKGTDLISTAPLDKLKTKLNVLLKGDGTNEIKEDRGKWWTENRTRVWHAMLCGYKAAGGKIEERDCSLPDDNTHQFLRWFREWSEHFCAKRQKLFNEVKRECASAQCIIEYGTIDPPVCEEACTQYRDYITRKIQEYRLLNYQYNTNFNEKKAEVTKAPEYFNDKCNDKCNCLSKYIDIEKKWKNMYDSFDDNDLKNKCICRQIKPKRPPKKVKPEEEHTPSEQDTPPPLPPKPDDLPPPAEEPFNRDILEKTIPFGIALALGSIAFLFLKKKTKSSVGNLFQILHIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSGTDSGYTDHYSDITSSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTQNDIQNDGIPSSKITDNEWNTLKDEFISNMLQNEPNTEPNMLGYNVDNNTHPTTSRHNVEEKPFIMSIHDRDLYSGEEYSYNVNMVNNDIPISARNGNYSGIDLINDSLNSNKVDIYDELLKRKENELFGTNHTKKNTSTNSVAKNTNTDPIHNQLNLFHTWLDRHRDMCEKWDTNNKKEELLDKLKEEWNKDNNSGNINPSGNTPPTSDIPSGKQSDIPSDNNIHSDIPYVLNTDVSIQIHMDNPKPINEFSNMDTYPNNSSMDTILEDLDKPFNEPYYYDVQDDIYYDVHDHDTSTVDTNAMDEPSKVQIEMDVNTKLVKEKYPIADLWDI
Protein: Non-structural polyprotein (Q809B7)
Organism: Semliki forest virus (SFV)
Interaction partners:
Sequence:
MAAKVHVDIEADSPFIKSLQKAFPSFEVESLQVTPNDHANARAFSHLATKLIEQETDKDTLILDIGSAPSRRMMSTHKYHCVCPMRSAEDPERLVCYAKKLAAASGKVLDREIAGKITDLQTVMATPDAESPTFCLHTDVTCRTAAEVAVYQDVYAVHAPTSLYHQAMKGVRTAYWIGFDTTPFMFDALAGAYPTYATNWADEQVLQARNIGLCAASLTEGRLGKLSILRKKQLKPSDTVMFSVGSTLYTESRKLLRSWHLPSVFHLKGKQSFTCRCDTIVSCEGYVVKKITMCPGLYGKTVGYAVTHHAEGFLVCKTTDTVKGERVSFPVCTYVPSTICDQMTGILATDVTPEDAQKLLVGLNQRIVVNGRTQRNTNTMKNYLLPVVAVAFSKWAREYKADLDDEKPLGVRERSLTCCCLWAFKTKKMHTMYKKPDTQTIVKVPSEFNSFVIPSLWSTGLAIPVRSRIKMLLAKKTKRELIPALDASSARDAEQEEKERLEAELTREALPPLVPIAPAETGVVDVDVEELEYRAGAGVVETPRSALKVTAQPNDVLLGNYVVLSPQTVLKSSKLAPVHPLAEQVKIITHNGRAGRYQVDGYDGRVLLPCGSAIPVPEFQALSESATMVYNEREFVNRKLYHIAVHGPSLNTDEENYEKVRAERTDAEYVFDVDKKCCIKREEASGLVLVGELTNPPFHEFAYEGLKIRPSAPYKTTVVGVFGVPGSGKSAIIKSLVTKHDLVTSGKKENCQEIVNDVKKHRGLDIQAKTVDSILLNGCRRAVDILYVDEAFACHSGTLLALIALVKPRSKVVLCGDPKQCGFFNMMQLKVNFNHNICTEVCHKSISRRCTRPVTAIVSTLHYGGKMRTTNPCNKPIIIDTTGQTKPKPGDIVLTCFRGWVKQLQLDYRGHEVMTAAASQGLTRKGVYAVRQKVNENPLYAPASEHVNVLLTRTEDRLVWKTLAGDPWIKVLSNIPQGNFTATLEEWQEEHDKIMKVIEGPAAPVDAFQNKANVCWAKSLVPVLDTAGIRLTAEEWSTIITAFKEDRAYSPEVALNEICTKYYGVDLDSGLFSAPKVSLYYENNHWDNRPGGRMYGFNAATAARLEARHTFLKGQWHTGKQAVIAERKIQPLSVLDNVIPINRRLPHALVAEYKTVKGSRVEWLVNKVRGYHVLLVSEYNLALPRRRVTWLSPLNVTGADRCYDLGLGLPADAGRYDLVFVNIHTEFRIHHYQQCVDHAMKLQMLGGDALRLLKPGGNLLMRAYGYADKISEAVVSSLSRKFSSARVLRPDCVTSNTEVFLLFSNFDNGKRPSTLHQMNTKLSAVYAGEAMHTAGCAPSYRVKRADIATCTEAAVVNAANARGTVGDGVCRAVAKKWPSAFKGAATPVGTIKTVMCGSYPVIHAVGPNFSATTEAEGDRELAAVYRAVAAEVNRLSLSSVAIPLLSTGVFSGGRDRLQQSLNHLFTAMDATDADVTIYCRDKSWEKKIQEAIDMRTAVELLNDDVELTTDLVRVHPDSSLVGRKGYSTTDGSLYSYLEGTKFNQAAIDMAEILTLWPRLQEANEQICLYALGETMDNIRSKCPVDDSDSSTPPRTVPCLCRYAMTAERIARLRSHQVKSMVVCSSFPLPKYHVDGVQKVKCEKVLLFDPTVPSVVSPRKYAASTTDHSDRSLRGFDLDWTTDSSSTASDTMSLPSLQSCDIDSIYEPMAPIVVTADVHPEPAAVHPEPADHVDLENPIPPPRPKRAAYLASRAAERPVPAPRKPTPAPRTTFRNKLPFTFGDFDEHEVDALASGITFGDFDDVL
Protein: Fibulin-1 (B1WC21)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR036313}.
Interaction partners:
Sequence:
MERPAPSRLVPLPLLLLGSLSLLAARANADISMEACCTEGNQMANQHRDCSLSYTSESKECRMVQEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLETIFIKRCCHCCMLGRAAQARGQTCEPNLMISYQCGLVFRACCVKGQENSDFVRGDGTDLQDPAKIPEEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGYYFDGISRTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTRCERLPCHENQECPRLPLRITYYHLSFPTNIQVPAVVFRMGPSSAVPGDSMQLAITAGNEEGFFTTRKVSHHSGVVALTRPIPEPRDLLLTVTMDLYRHGTVSSFVAKLYIFVFAEL
Protein: Hydroxyethylthiazole kinase (EC 2.7.1.50) (4-methyl-5-beta-hydroxyethylthiazole kinase) (TH kinase) (Thz kinase) (Q9LIQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiazole kinase involved in thiamine salvage pathway.
Interaction partners:
- Thiamine biosynthetic bifunctional enzyme TH1
- Thiamine thiazole synthase, chloroplastic
- Bifunctional TENA-E protein
- Thiamine pyrophosphokinase 2
- Thiamine pyrophosphokinase 1
- 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212
- Bifunctional TH2 protein, mitochondrial
- Phosphomethylpyrimidine synthase, chloroplastic
- Nudix hydrolase 24, chloroplastic
- Purine-uracil permease NCS1
Sequence:
MESKSEQNEWSSGVWAHLTAVRQQSPLVQCITNFVSMDLVANTLLSAGASPAMVHSVVEIPDFTPHIHALCVNVGTLTPDWLPSMKAAAELASQLRKPWVLDPAAVSCSGFRLKACLELIELKPTVIKGNGSEIIALSSASRGQTKGADSSHESTDAIEAAKSLAMSSGAVVAVSGAVDIVTDGKQVIGVHNGTKMMQQITATGCSLAGLIVAFLAIDSSRVLEATVSAMAVFGIAGELGEAMANGPASLRMHLIDCLYGLDETTVLKRVNVTRLG
Protein: Claudin-11 (Oligodendrocyte transmembrane protein) (Oligodendrocyte-specific protein) (Q60771)
Organism: Mus musculus (Mouse)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell junction, tight junction. Cell membrane {ECO:0000250|UniProtKB:O75508}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tight junction protein 1
- Occludin
- Tight junction protein ZO-3
- Claudin-23
- Claudin-3
- Claudin-2
- Claudin-13
- Claudin-17
- Claudin-14
- Claudin-5
Sequence:
MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV
Protein: Carnosine N-methyltransferase (EC 2.1.1.22) (P53934)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Interaction partners:
- Putative uncharacterized protein YNL089C
- Uncharacterized protein YMR209C
- Ribosomal lysine N-methyltransferase 5
- 25S rRNA
- Uncharacterized transporter YNL095C
- Ribosomal lysine N-methyltransferase 3
Sequence:
MDENEFDNQRENKAVARVIISFLKYEEYALKEIYNLRVKKWASISDRQKDMVPNYTKYLANLKAAIIENGKFFRSVAEYALQSISFEPGEIVQPNDLDMSKTCSLLTQVYREWSAEAISERNCLNSRLVPFLKTLSPPKADILIPGCGTGRLLVDLSRMGYNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQLSPIKVPDIEAWSSNKGMGSMSICAGSFVDCYGRNQGTKISSHYTFSRRMQLSRAKAENSKDVVVTNFFIDTGSNILDYLDTIGHVLKPGGIWCNFGPLLYHFENDHGVETTYEVNPYSGFQDKINDYTPLMGLELSSDDIISIATNHLDFELIRRESGILCGYGRYAGPESCAMPGYMCHYWILKSNPTNES
Protein: Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP kinase sur-1) (P39745)
Organism: Caenorhabditis elegans
Function: Functions in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage, perhaps acting after efl-1/dpl-1-mediated gene activation and before gld-1 down-regulation. May play a role in global X chromosome reactivation or be indirectly required for progression of germ cells through meiosis to the point where X reactivation occurs. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. In addition, involved in the up-regulation of lysozyme ilys-3 expression in the intestine in responses to M.nematophilum-mediated bacterial infection. By phosphorylating transcription factor skn-1 (isoform c) may play a role in increasing life span downstream of lin-45, let-60 and mek-2. By up-regulating cep-1 and down-regulating gld-1 expression in the late pachytene stage, plays a role in germline apoptosis in response to DNA damage. Regulates egl-1 expression in response to DNA damage, probably upstream of cep-1.
Interaction partners:
- Dual specificity protein phosphatase lip-1
- Dual specificity mitogen-activated protein kinase kinase mek-2
- ETS domain-containing protein
- Ras protein let-60
- Tyrosine-protein phosphatase vhp-1
- Putative ribosomal protein S6 kinase alpha-1
- Forkhead box protein O
- MAP kinase-interacting serine/threonine-protein kinase mnk-1
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
- Dwarfin sma-2
Sequence:
MPTWIPNNLCAQPTTRNAKPPSNGHPQATQQQSAPGSLAYRNSSNIPNGATNHVRQQKWQYTRSGHRKMADGEAVISTVNNVEEVHGQLFEVAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEEPFTLEMEFDDLPKEKLKELIWEEAEAHHRRMEAEAAARNNGGQNPV
Protein: Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) (Q9Y6X4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:22412018}. Nucleus inner membrane {ECO:0000269|PubMed:22412018}; Peripheral membrane protein {ECO:0000269|PubMed:22412018}; Nucleoplasmic side {ECO:0000269|PubMed:22412018}. Note=Enriched at the nuclear lamina.
Interaction partners:
Sequence:
MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGGDQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLNRIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVLDTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLWEVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSEMQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQTSLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEKESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKPPEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSDGGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVPFSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHKGPAKKKAKLT
Protein: Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (P54690)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8381418}.
Interaction partners:
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Cystathionine gamma-lyase
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Amine oxidase
- Glutamate--cysteine ligase catalytic subunit
- Amine oxidase.
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Glutamate--cysteine ligase regulatory subunit
- Amine oxidase
Sequence:
MAYLSRATATLARQDCSNGCSASYAEEEELEASTESYDEEGGSEASTQTFRAKDLIITKADVLKKKPDPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENRITEVGTMNLFLYWINKDGEEELATPPLDGVILPGVTRQSILELGEEWGEFKVCERHITMDDLSTALEENRVKEMFGSGTACVVCPVASILYKGQMLHIPTMENGHKLSSRIMAKLTDIQYGRIKSEWTLELP
Protein: Brakeless protein (Q9NGW5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEKKLAKVALNSSNVATESNIKNNKLLANLSAAGAATATTATTGTATTTTATTANQALNFNNKTKATANATAASANNRHNNNNNSSAIKKHTNTKQLAGKSPACNSSSSSLSSSSSSNSSESKDTNFEYEDEWNIGGIPELLDDLDADIEKSAHSSGGGNQATALNAKQANSSSTSSSSSSKGGASSSSSSAAATGSSSSHKSHKTTLHSNLSATSPTTIKFTRQPVAIGGLNSSSSSSAAAAPSGGSANVVAKGSSSSSSSTSSSSSGKHHHHHHHHSNSSSSGSSSKGYKSALVAQLNSPSPLNSNSKSLSGSGSGSGNTNGAAGAGAGSTLSSSTFAGFSKGGSLVSSSAGAAAALAAGSGQQGSKFSAGGMSSQTGSGSGGNNTSNSNNSTSGSGGSGSGSSTGNTASGSGNNNSTSAGGPPSSQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQQNGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSGSSSSGGGSQNNASGHATGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASAAGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMSAVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSIAGGVGGSGGGANAPGPPGKESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMISATMHHTISVPAGTGTGDDDTKSPPAKMVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPR
Protein: Trafficking protein particle complex subunit 5 (Q9NA81)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222, ECO:0000256|PIRNR:PIRNR017479}.
Interaction partners:
- Trafficking protein particle complex subunit 3 homolog
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 9
- Trafficking protein particle complex subunit 10
- Probable trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 11 domain-containing protein
Sequence:
MAKTTGILDKSLSRGKTEINLSTFAVLFSEMVLYAQNRSETVTDIHDKIASYGKQVGLRMFDIITLREKGYKRETKLLGMLMFIKSTVWKNLFGKEADKLERSNDDHCTYLLIEKDPMVNTYISVPRDKGVLNCAAFAAGIVEAILESASFKCKVTAHWHNGTAYVIQFDESVIARENSLLDSNR
Protein: Small ribosomal subunit protein RACK1 (C0H7X9)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MTEQMTVRGTLKGHNGWVTQIATTPQFPDMILSASRDKSIIMWKLTRDETNYGIPQRALKGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLGVCKYTIQDESHSEWVSCVRFSPNSSNPIIVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCAFGGKDGQAMLWDLNEGKHLYTLDSGDNINALCFSPNRYWLCAAPGPSIKIWDLEGKIIVDELRQEVISPNSKAEPPQCTFLAWFADGQTLFAGYPDNLIRVWQVSIGTR
Protein: Monothiol glutaredoxin-S11 (AtGrxS11) (Protein ROXY 6) (Q9M9Y9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- tRNA-dihydrouridine synthase
- Protein RETICULATA-RELATED 3
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase D1
Sequence:
MDKVMRMSSEKGVVIFTKSSCCLSYAVQVLFQDLGVNPKIHEIDKDPECREIEKALMRLGCSKPVPAVFIGGKLVGSTNEVMSMHLSSSLVPLVKPYLC
Protein: TonB-dependent receptor (Q9I245)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}.
Interaction partners:
- histidine kinase
- Probable transcriptional regulator
- Uncharacterized protein
- Probable outer membrane protein
- Beta-monoglucosyldiacylglycerol synthase
- Probable carbamoyl transferase
- Elongation factor G 2
- Uroporphyrinogen decarboxylase
Sequence:
MHRSLHTDAPLGAALLLALQLAPGSAAAAEEQAPVDPPTVQLQRIEVTGSAIRRVDAETAVPISVLRAEELRQQGVTSTEELIGRLSGNQGVYNSSRSVGSATGGASFADLRGIGANKTLVLLNGRRLANNAIDGSAVDLNTIPFAAIDRVEVLRDGASALYGTDAIGGVINFITRKSLNEGRFDSGYASPTHDGGGNQRNVSASWGFGELEEDRFNVFAVANYDKQERLGAKDRGYTYNYQPGRGLDYSSGTAFPGNWSQGANASNPLAAGGCKGADLIPRNGICRQSLWRYLDLVPETEKTSVFSRATGKLADEHNVSLEYFWSRSDNATQVGPGTLTGLQIDPGTAFYPGNGITPGPGGFVLDPSRPVEVNWRQSVLGPRLQSSQNTGQRLLLGFDGQFAGWDYDIGASYNQNKVVDHIHSGYVDDRAAALGIANGTLNPFGPQTDAGLAYLGSHALSGDFRTSVGRVKGLDARASREIGDWFGAGPAALALGGEFRKEAFHQDIQDFAGNVQSLGVDPAATVSGERNLKAQYAELNVPVLDSLELSAAIRHDKYSDFGSTSNPKYSFRFQPFRQLVLRGAYSEGFRAPSLYELYNPTFTTYTSANYDDPRLCAGGQPSQGGIANRDCAQQFYNATGGNTDLRPETARNVTLGLVYQPLRDLSVGLDFWWIRIANQIAEFPEAAIFADPQAYAGRIVRKADGSIDHVVTGLANLGKVKTSGVDLSLDYRFPASRYGQFGLDLQGTYVSRYDFQQQIGGQYLDNVGDFQGVGVIARWKHVANATWSRDAWQATLSNRYTSGYNDYDRASHGKVGSWNLWDLAGSYRLSHALGLTLGVKNLFDREPPFSNQTYTFQSGYDPRYTDPYGRILFGRLSYSF
Protein: Lipid uptake coordinator A (O69690)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required for the import of both fatty acids and cholesterol during growth in macrophages and in axenic culture. Facilitates the uptake of these lipids by stabilizing protein subunits of the Mce1 and Mce4 multi-subunit transporters, which transport fatty acids and cholesterol, respectively. Required for full virulence in vivo.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28708968}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Fatty acyl-CoA reductase Rv0547c
- Uncharacterized protein Rv2308
- Uncharacterized protein Rv1414
- Conserved hypothetical integral membrane protein YrbE2A
Sequence:
MGRKVAVLWHASFSIGAGVLYFYFVLPRWPELMGDTGHSLGTGLRIATGALVGLAALPVVFTLLRTRKPELGTPQLALSMRIWSIMAHVLAGALIVGTAISEVWLSLDAAGQWLFGIYGAAAAIAVLGFFGFYLSFVAELPPPPPKPLKPKKPKQRRLRRKKTAKGDEAEPEAAEEAENTELAAQEDEEAVEAPPESIESPGGEPESATREAPAAETATAEEPRGGLRNRRPTGKTSHRRRRTRSGVQVAKVDE
Protein: Uncharacterized oxidoreductase YKL071W (P36086)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Probable aryl-alcohol dehydrogenase AAD4
- NADP-dependent alcohol dehydrogenase 7
- Uncharacterized protein YKL070W
- NADPH-dependent aldehyde reductase ARI1
Sequence:
MNTSSRITYFIIGGSRGIGFNLVKILSASTGNTVITSIRGSPSLPKNKQVEDLAKIRKNIHIVQLDLTKDESIGNIADEIKKTPFFLGIDIFIACSAVSDSYYKVLETPKSVWLNHYSTNALGPILALQKVYPLLLLKKTRKIFFISSVAGSINAFVPLSVSAYGQSKAALNYAVKTLSFELKPEGFTVVAFHPGMVSTDMGQYGLDHFKEKNIDISGVNIITPEESASALIDVFRKILPEDNGKFFNYDGSEGVF
Protein: Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Epo-immediate response gene protein FM22) (Q3TIV5)
Organism: Mus musculus (Mouse)
Function: Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q8WU90}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes. {ECO:0000250|UniProtKB:Q8WU90}.
Interaction partners:
- Developmentally-regulated GTP-binding protein 1
- Developmentally-regulated GTP-binding protein 2
- RWD domain-containing protein 1
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS12
- DnaJ homolog subfamily C member 2
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS5
Sequence:
MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCRHFLEAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSMGVNDIDISLYVPRDVEETGITVASVERFSTYAPDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE
Protein: Endonuclease III family protein (Q9A623)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Endonuclease III lyase)
- Formamidopyrimidine-DNA glycosylase
- Ribosomal RNA small subunit methyltransferase A
Sequence:
MQLSLALARSPLESVRDALLCEFGPQRPVARMDPISQLVKSSISGRTPDAVSWAAFLRLRAEFKSWEDLAEAKTARVAMAIQDVTFPEDKARRLITALRMIEEKVGWLSLSHLKTLEVDQARWELQALPGVGVKVAACVLNFSDLAMRALVVDTHVDRVARRIGLVGSGDTTNTYHTLMAMAPASWTADDLFELHWLMKRGLGQMLCGAEAPKCGACPVKQMCAKAGVGHSAEVLAWRPRG