wanglab/gogpt-training-data huggingface dataset:
Protein: NAC domain-containing protein 30 (ANAC030) (Protein VASCULAR RELATED NAC-DOMAIN 7) (Q9C8W9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression. Can activate the expression of several genes including XCP1, MYB46, NAC010/SND3, MYB103, MYB58, MYB63, MYB83, KNAT7, ASL19 and ASL20.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:18445131}.
Interaction partners:
- Transcription factor MYB46
- At5g52380
- Transcription factor MYB83
- Cysteine protease XCP1
- NAC domain-containing protein 83
- Transcription factor MYB63
- LOB domain-containing protein 30
- MYB transcription factor
- Homeobox protein knotted-1-like 7
- Cellulose synthase A catalytic subunit 4
Sequence:
MDNIMQSSMPPGFRFHPTEEELVGYYLDRKINSMKSALDVIVEIDLYKMEPWDIQARCKLGYEEQNEWYFFSHKDRKYPTGTRTNRATAAGFWKATGRDKAVLSKNSVIGMRKTLVYYKGRAPNGRKSDWIMHEYRLQNSELAPVQEEGWVVCRAFRKPIPNQRPLGYEPWQNQLYHVESSNNYSSSVTMNTSHHIGASSSSHNLNQMLMSNNHYNPNNTSSSMHQYGNIELPQLDSPSLSPSLGTNKDQNESFEQEEEKSFNCVDWRTLDTLLETQVIHPHNPNILMFETQSYNPAPSFPSMHQSYNEVEANIHHSLGCFPDS
Protein: Ion_trans_2 domain-containing protein (SLO-2 potassium channel) (G5EDJ1)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSDDTNNRTDRCTMKHRERRVDSCHSLPSDYRIPNKHVARMQYGEKKNIKHKLQQWFIENPSISARIRSCNVLIKLLTCILYCIRVVNDERSYPDDFPFSEEEAGKQDVTLYKYLLWVDFDFKIWFLQTMFACISMVYTILVFYLSYSGSVVRLLINIHFLLELITSFPFIISIFIPSLTYLYVPVFLNCWLAKGALQAMMNDLNRKSFISSSALFRQLLLLFSVLACLIFTGMCSIEHLQRARGKRIDLFTSFYFVMVTFSTVGYGDWYPDYWASQLCVVILICVALGLIPKQLDELGQTWSERQKSGTDFSSWNGVESHVVVTITTLEVEFIRDFLEEFYAHPENQRIQIVLLSPAELDNQTRMLLKIPLWNNRVHYVRGSSLRDEDLERANVATSKACFILSARHVNRKVATDEHTILRSWAIKDFAPNVKQYVQIFRAETKMHIEHAEVLICEDEFKYALLANNCICPGISTFITLLMHTSRGEEGQKSTEPWHKVYGFHSGNEMYQIKVQDSKFFCEYVGKSFSSTSFHAHKEYGIGLIAVSPDGDTSRMKLNPGSSHIIQPTDTVYYMGLTNEESLTDFRKGIRSQQKRANVASTIANIGTVAVDVPRSDKTELVGRKKKKRKEKAADEIHLIEVGEHVQSSRRPSIAMVTEGKIDSSSDSDQEEICDKCRGPCIQHKLQRTYPQVRTYIGTSNTVCHMMKERRSLCCLKLDEKCAHKSATSAHEYQWRNRPIILAADRTSSGMYNLVIPLRAYYRPVHDLHPIIILLELEEQDSLNDAFLDAISYFPDVYWMKGKVGNLDCLLRAGVSSAEHVVVVKETAVMAEEHTADCNTIITVQKIHRMFPRLRMITELTHATNMRFVQFNPHNAYSLAQSRFEKKERKRGSHMPFMFRLPFAQGGVFSANMLDRLLYQAIIKPFVVDLVRLLLGIDQHSDGGYLTSFVITSDDLWIRNYGRLYQKLCSSVADIPIGIFRTKKMDTKTVSLDLQEQCKDFENTEMGRNKDMYDHVKNRMRLLNIKDTHTLLEGSDEKSQISYVIINPAQDLELESGDIVYVIRSPIRKDATNARINPRRGLRRSKNVSETIDSTNQVPTIVIDENNL
Protein: Phospholipase (EC 3.1.4.4) (B7YZT5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037868}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037868}.
Interaction partners:
- Eye-specific diacylglycerol kinase
- Diacylglycerol kinase
- Diacylglycerol kinase
- GM01519p
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- LD39232p1
- Phosphatidate cytidylyltransferase, photoreceptor-specific
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- FI05338p
- GH11618p
Sequence:
MMATCLDTKTSKNHEAQQLQLPRQASSNANLPHLQVRRHRRSISQLMASMVEHPTDDVYRPAHYGGYVNRGYDDLDSSYYFAQYEAMADAGTVGGALPPYALTNSDEEHGSGEEDASEENSNNEEGEGVFRDCTDEAVVEHHNRCLPEFQFSLVDSEYDETLAFPDSVTILSNVGDKPVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFIPGREIHVRIVDTERSVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCNYFCSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTLAKHENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPSTLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSAEVYTIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNTRFPYLMPKSYHQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT
Protein: Spermine synthase (F7EX49)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAARHSTLDFTLGAKADGEAILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDSDVQGKQETDCLLNKIEEKMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGNGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRRTCGDVLDNLKGDCYQGLYDICAVSGEKSGVILVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
Protein: Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (mDEC2) (Q99PV5)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Period circadian protein homolog 2
- Cryptochrome-1
- Circadian locomoter output cycles protein kaput
- Basic helix-loop-helix ARNT-like protein 1
- Class E basic helix-loop-helix protein 40
- Cryptochrome-2
- Casein kinase I isoform epsilon
- Glycogen synthase kinase-3 beta
- Nuclear receptor subfamily 1 group D member 1
- Neuronal PAS domain-containing protein 2
Sequence:
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVPSGRGSGRAPCSAGAAAASGPERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDSSPAPKRPKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGATAGAPFLAHEVAPPGPLRPQHAHSRTHLPRAVNPESSQEDATQPAKDAP
Protein: PDZ domain-containing protein (Q18167)
Organism: Caenorhabditis elegans
Interaction partners:
- SPerm CHromatin enriched
- Membrane transporter protein
- non-specific serine/threonine protein kinase
- PDZ domain-containing protein
- non-specific serine/threonine protein kinase
- PDZ domain-containing protein
- PDZ domain-containing protein
- Expressed conserved protein
- Nematode Specific Peptide family
- DUF389 domain membrane protein
Sequence:
MGSEKMIEICIDMEEGEPLGATPNDKLVITKIQAGTISEGKLRIGDQVKKVNGQNCKDCNDFFRALRFAAPCAKIMVNRDEKKAEELEARVHIPEDRAKIIQRREGYVYELATLVWVQNGPKLGLGIKHFQNRVLVSRVDPGSLAEKCLVLGDHLCDVDGIPVSDKDVARDLLVKNIQEKGKVTFVVERPDSIDAKQWAKQALATNLMQPPSVQMNEDVKGIASQYRQALPGLKPPAKSAMSTGPSARRVSIVEQTQTHEIGHDHEGKALRKVK
Protein: Nickel/cobalt homeostasis protein RcnB (P64534)
Organism: Escherichia coli (strain K12)
Function: Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly.
Subcellular location: Periplasm {ECO:0000269|PubMed:21665978}.
Interaction partners:
- Nickel/cobalt efflux system RcnA
- Transcriptional repressor RcnR
Sequence:
MTIKNKMLLGALLLVTSAAWAAPATAGSTNTSGISKYELSSFIADFKHFKPGDTVPEMYRTDEYNIKQWQLRNLPAPDAGTHWTYMGGAYVLISDTDGKIIKAYDGEIFYHR
Protein: RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) (P42700)
Organism: Xenopus laevis (African clawed frog)
Function: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May play roles in cilia formation and/or maintenance (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P10155}.
Interaction partners:
Sequence:
MEATMDQTQPLNEKQVPNSEGCYVWQVSDMNRLRRFLCFGSEGGTYYIEEKKLGQENAEALLRLIEDGKGCEVVQEIKTFSQEGRAAKQEPTLFALAVCSQCSDIKTKQAAFRAVPEVCRIPTHLFTFIQFKKDLKEGMKCGMWGRALRKAVSDWYNTKDALNLAMAVTKYKQRNGWSHKDLLRLSHIKPANEGLTMVAKYVSKGWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLVREHLLTIHLKSKEIWKSLLQDMPLTALLRNLGKMTADSVLAPASSEVSSVCERLTNEKLLKKARIHPFHILVALETYKKGHGNRGKLRWIPDTSIVEALDNAFYKSFKLVEPTGKRFLLAIDVSASMNQRVLGSILNASVVAAAMCMLVARTEKDSHMVAFSDEMLPCPITVNMLLHEVVEKMSDITMGSTDCALPMLWAQKTNTAADIFIVFTDCETNVEDVHPATALKQYREKMGIPAKLIVCAMTSNGFSIADPDDRGMLDICGFDSGALDVIRNFTLDLI
Protein: site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) (Q5F8W9)
Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Interaction partners:
- Type III restriction-modification system HindVIP enzyme res
- Restriction endonuclease EcoPI subunit R
Sequence:
MKTGIQTELAQALLSHEKIWANEEKTILAKNILLDLVEKTDPSIIGLLLNNDELKRHFFVEVNGVLVFKLQDFRFFLDKHSINNSYTKYANRIGLTDGNRFLKDNSDIVLDFPFKDCVLNGGQSTEEGEEIYFKRNNSQPASQPASQPASQPASQPASQPASQPASQPASQPASQPASQPASQPASQLYTKLTRKRQEIFFNQTLAFDEIDRLFDAKAFSKFSRHTADGKQPVGEIKRRSDGTPAENLIIKGNNLIAMHSLAKQFKGKVKLIYIDPPYNTETDSFAYNDKFSHSTWLTFMKNRLEIAKELLKDDGLIFVQCDDKEQAYLKVLLDETFTRENFINCIAVKMSEPSGNKMAHTSHRLPKIKEYILIYKNKNIKLNPIREQKSEWDNEYNIFLENFTQEDKKFIDLIVNSQTENKEINGNTLKEIDILLKKISPISVNQKLAQLNIKDNEVIKWKLDNAYRIVRTAASSSVKKLADEKKEICQQQFFSVISKRDKLLYIVKSDYSKDAKAPRVQVLFAEDYLSISLCDLWTNINTTGLEAEGNVELKNGKKPESLIETIIKLATNENDIVLDYHLGSGTTAAVAHKMNRQYIGIEQMDYIETLAVERMKKVIDGEQGGISKAVNWQGGGEFVYAELSPFNETAKQQILACENSDGIKTLFEGLCERHFLKYNVSVNEFSQIIEEPEFQSLALDEQKQMMLEMLDLNQMYISLSEMDDEQFAGCLNDDDKALSRAFYQSVKHQAEKKDGE
Protein: U-box domain-containing protein 6 (EC 2.3.2.27) (Plant U-box protein 6) (RING-type E3 ubiquitin transferase PUB6) (O48700)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- At2g17660 family protein)
- Monothiol glutaredoxin-S1
- Vacuolar iron transporter homolog 2.1
- Berberine bridge enzyme-like 18
- Transcription factor bHLH148
- Protein DETOXIFICATION 50
Sequence:
MDVSELEENLFAASDAKLHGDMCKELSAVYCKVLSIFPSLEEARPRSKSGIQTLCSLHIALEKAKNILQHCSECSKLYLAITGDAVLLKFEKAKSALIDSLRRVEDIVPSSIGSQILDIVGELEHTKFLLDPSEKEVGDRIIALLQQGKKFDNGSDSTELEIFHQAATRLSITSSRSALAERRALKKVIDRARVEEDKRKESIVAYLLHLMRKYSKLFRSEMMDENDSPCSTPCSPTGQGPNEDRVNAFGRQLSKFGSINYKPMNSRKSGQMPIPPEELRCPISLQLMYDPVIIASGQTYERVCIEKWFSDGHNSCPKTQQQLPHLSLTPNYCVKGLIASWCEQNGITVPTGPPESLDLNYWRLAMSDSESPNSKSVDSVGLCTPKDIRVVPLEESSTIESERQQKEKNNAPDEVDSEINVLEGYQDILAIVDKEEDLAKKCKVVENVRILLKDNEEARILMGANGFVEAFLQFLESAVHDNNAAAQETGAMALFNLAVNNNRNKELMLTSGVIPLLEKMISCSQSQGPATALYLNLSCLEKAKPVIGSSQAVSFFVNLLLQDTKTQCKLDALHALYNLSTYSPNIPTLLSSNIIKSLQVLASTGNHLWIEKSLAVLLNLASSREGKEEMITTQGMISTLATVLDTGDTVEQEQAVSCLVILCTGSESCIQMVLQEGVIPSLVSISVNGSPRGRDKSQKLLMLFREQRHRDQPSPNKEEAPRKTVSAPMAIPAPVSAPESEVKPLTKSISRRKTMTRPFSFLWKKSHSIHH
Protein: P-type Ca(2+) transporter (EC 7.2.2.10) (H0Y9V7)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004166}.
Interaction partners:
Sequence:
XKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSSSFLEVWLWERSGQQLVEIHPHLETGLPLTEDVSCV
Protein: Lipopolysaccharide 1,6-galactosyltransferase (EC 2.4.1.-) (UDP-D-galactose:(Glucosyl)lipopolysaccharide-alpha-1,3-D-galactosyltransferase) (P27127)
Organism: Escherichia coli (strain K12)
Function: Adds a galactose goup to a glucose group of LPS.
Interaction partners:
- Lipopolysaccharide glucosyltransferase WaaO
- Lipopolysaccharide 1,2-glucosyltransferase
- Lipopolysaccharide core biosynthesis protein WaaS
- Putative lipopolysaccharide heptosyltransferase 4
- Lipopolysaccharide glucosyltransferase WaaG
- Lipopolysaccharide core heptose
- Lipopolysaccharide core heptose
- Lipopolysaccharide heptosyltransferase 3
- Probable 3-deoxy-manno-octulosonic acid transferase
- O-antigen ligase
Sequence:
MKIAFIGEAVSGFGGMETVIRDVITTFRQQHIQSEMFFFCRNDKMDKGWLEGIKYSCSFSNIRLGFLRRAKHIHALSKWLQEYQPDIVICIDVISCLFAAKARKKSGIDMPVFSWPHFSLDHKKHAEYITCADYHLAISSGIKQQMINRGVAESTINVIFNPVETKDSVIPAPEEGETATFIYVGRMKFEGQKRVKDLLDGLSQAKGNWKLHVLGDGSDFEKCQAYGRELNIDDRIVWYGWQQYPWELVQQDIEKVSALLLTSSFEGFPMTLLEALSWGIPCISADCVSGPADIIQPDVNGHLYQPGDIAGFVTLLNKYIAGEIHIEHEKIPASIDEFYQSKYYDRLHKVIISAISRRK
Protein: Possible ketoacyl reductase (Q10782)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized oxidoreductase Rv1543
- Putative diacyglycerol O-acyltransferase Rv3480c
- Putative diacyglycerol O-acyltransferase Rv1760
- Putative diacyglycerol O-acyltransferase Rv1425
- Uncharacterized protein Rv1546
- Uncharacterized protein Rv1545
Sequence:
MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGLCNSAGFGTSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLAQVSPHDVAEAAIAGMLSGKRTVVPGIVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR
Protein: Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2) (P15153)
Organism: Homo sapiens (Human)
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Subcellular location: Cytoplasm. Note=Membrane-associated when activated.
Interaction partners:
- Neutrophil cytosol factor 2
- Neutrophil cytosol factor 4
- Cytochrome b-245 light chain
- NADPH oxidase 2
- Neutrophil cytosol factor 1
- Dedicator of cytokinesis protein 2
- Rho GDP-dissociation inhibitor 1
- Dedicator of cytokinesis protein 1
- Rho GDP-dissociation inhibitor 2
- NADPH oxidase organizer 1
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRACSLL
Protein: Uncharacterized MFS-type transporter C18.02 (O74852)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vacuolar ATPase assembly integral membrane protein vph2
- AP-3 complex subunit beta
Sequence:
MGLKLWVKQRRSLPFIIGTIAIALFTDLFLYGIITPILPFSLVDRVGISPDRVQSVISTLLAVYAVANIAASSPIGFLADKFLTRKVPMLIGLIFLTSATALLTFGNSVPMLIVARVLQGLSAAVVWTVGLALLVDVVGADNVGSTMGGIFGFISLGEIIAPVFGGIVYESLGYYASFGVCFIILLLDIALRFLMIEPREMKNDSTLQDVERTSILQRQDTQDHELKPKRSGLFSSLCLPIYSLLHHKQIFGPFWTSFVNSCLFSAFDATIPLELKTLFDFNSLQCGLMFGVLSTPYFFCGAWAGAMVDRRGSRTIGKRAYAILGCTLFLLCIPRTNTSLNIYLFSAFLAINGVVLAFTSSPGFVQSSHYVAEYELEHPTFFGHNGPYTQLFSAYNIVYSLGMIIGPLVAGFLRDQFNFITSIACLSLLCFSASLMANSCFTDRLDSE
Protein: Superoxide dismutase [Fe] (EC 1.15.1.1) (FeSOD) (Q8IAY6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Superoxide dismutase
- Aconitate hydratase
- Ribosomal protein L13
- Large ribosomal subunit protein uL29m
- Mitochondrial ribosomal protein L46, putative
- 40S ribosomal protein S11, putative
- Mitochondrial ribosomal protein S5, putative
- Mitochondrial ribosomal protein S35, putative
- Mitochondrial ribosomal protein L11, putative
- 30S ribosomal protein S2, putative
Sequence:
MVITLPKLKYALNALSPHISEETLNFHYNKHHAGYVNKLNTLIKDTPFAEKSLLDIVKESSGAIFNNAAQIWNHTFYWDSMGPDCGGEPHGEIKEKIQEDFGSFNNFKEQFSNILCGHFGSGWGWLALNNNNKLVILQTHDAGNPIKDNTGIPILTCDIWEHAYYIDYRNDRASYVKAWWNLVNWNFANENLKKAMQK
Protein: Kinesin-like protein KIN-10A (Phragmoplast-associated kinesin-related protein 2) (AtPAKRP2) (Q8VWI7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable plus end-directed motor protein that may contribute to the transport of Golgi-derived vesicles in the phragmoplast.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11701879}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:11701879}. Note=During interphase, present throughout the cytoplasm. Microtubule-associated during late anaphase. {ECO:0000269|PubMed:11701879}.
Interaction partners:
- 65-kDa microtubule-associated protein 3
- Kinesin-like protein KIN-14C
- Kinesin-like protein KIN-14D
- Kinesin-like protein KIN-14E
- Kinesin-like protein KIN-12A
- Mitotic spindle checkpoint protein BUBR1
- Kinesin-like protein KIN-14N
- Kinesin-like protein KIN-14M
- Kinesin-like protein KIN-10C
- Kinesin-like protein KIN-12B
Sequence:
MAPTPSSSRSNQTQYTLIRTPQTKQRLNFHSKTPNPDGSKDPSPPEHPVEVIGRIRDYPDRKEKSPSILQVNTDNQTVRVRADVGYRDFTLDGVSFSEQEGLEEFYKKFIEERIKGVKVGNKCTIMMYGPTGAGKSHTMFGCGKEPGIVYRSLRDILGDSDQDGVTFVQVTVLEVYNEEIYDLLSTNSSNNLGIGWPKGASTKVRLEVMGKKAKNASFISGTEAGKISKEIVKVEKRRIVKSTLCNERSSRSHCIIILDVPTVGGRLMLVDMAGSENIDQAGQTGFEAKMQTAKINQGNIALKRVVESIANGDSHVPFRDSKLTMLLQDSFEDDKSKILMILCASPDPKEMHKTLCTLEYGAKAKCIVRGSHTPNKDKYGGDESASAVILGSRIAAMDEFIIKLQSEKKQKEKERNEAQKQLKKKEEEVAALRSLLTQREACATNEEEIKEKVNERTQLLKSELDKKLEECRRMAEEFVEMERRRMEERIVQQQEELEMMRRRLEEIEVEFRRSNGGSVDETSGFAKRLRSLYSDDDPGMVKSMDLDMGDPEPVKQVWGAVSHQSSNTISSNFTNLLQPKPSENMLTQMYPDRVCLSTVFEEEEVEEEEEKVIVEDKSICLITTPMPSLNSEGLGKENCFNGADDKESASSRRLRIQNIFTLCGNQRELSQHSGQEEDQANIASPDKKDNQFFSITNKAEALAVEEAKENNISVDQRENGQLDIYVKWETAADNPRKLITTLRVTKDATLADLRKLIEIYLGSDNQAFTFLKLGEPCGAQVAKEKESTVQATSLPLCNGHAYLATLRPGKSSQHKSLQPASPLPLNPIENMMEVTPISKVTPNHQVDEFSSPNLVAHLSSTPFITLRRH
Protein: Hsp90 chaperone protein kinase-targeting subunit (Q336L8)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEIWKFCVKKKGNTVISRVFKRDSECEEEKFSKMPIDYSKWKDIEVSDDEDDTHPNIDTPSLFRWRHQARLERMAEKKMEQEKIDKEKGTTSKKMEELEKKLAAADVTDKSDIQKQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTIGHEAFSTSRINKITEKKPQAPKTDEEDTHAMSTFFETHESLLEKMAVLKNGAKSTELFLAEHPHMASEYTANWLTIEALNAAIDFNEEKMKTMAEQCIIIQYLLELSKSLNAVATNTTVQKQFFKKFEAAEPVYMKHYQDEVKAFEDRLRTRAQTKRDAAMEEAEAEEKAERMKSAPGGIDPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLWVPGKADDDDDDEEAAPAEEEPTTSS
Protein: BTB/POZ domain-containing protein KCTD14 (Q9BQ13)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWQGCAVERPVGRMTSQTPLPQSPRPRRPTMSTVVELNVGGEFHTTTLGTLRKFPGSKLAEMFSSLAKASTDAEGRFFIDRPSTYFRPILDYLRTGQVPTQHIPEVYREAQFYEIKPLVKLLEDMPQIFGEQVSRKQFLLQVPGYSENLELMVRLARAEAITARKSSVLVCLVETEEQDAYYSEVLCFLQDKKMFKSVVKFGPWKAVLDNSDLMHCLEMDIKAQGYKVFSKFYLTYPTKRNEFHFNIYSFTFTWW
Protein: Serine/threonine-protein kinase PknE (EC 2.7.11.1) (P9WI77)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Important for survival of the bacterium in the host during infection. Promotes the survival of infected macrophages by activating multiple signaling responses and suppressing apoptosis of macrophages during nitrate stress. May contribute to the adaptation of M.tuberculosis during stress conditions by maintaining the cellular integrity. Can phosphorylate the FHA domain of Rv1747.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12927792}; Single-pass membrane protein {ECO:0000269|PubMed:12927792}.
Interaction partners:
- Serine/threonine protein phosphatase PstP
- Glycogen accumulation regulator GarA
- FHA domain-containing protein FhaA
Sequence:
MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPVPSTHPVSPGTRWPQPTPWAGGAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIKSGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG
Protein: Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) (Q9UBW7)
Organism: Homo sapiens (Human)
Function: Involved in the negative regulation of transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:32891193}.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- Fibroblast growth factor receptor 1
- REST corepressor 1
- Histone deacetylase 1
- Histone deacetylase 2
- FGFR1 oncogene partner 2
- Small ubiquitin-related modifier 2
- Zinc finger MYM-type protein 3
- General transcription factor II-I
- PHD finger protein 21A
Sequence:
MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDSEIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQVGSHPSFLKEVRDHMQDSFLMQPEKYGKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSHKTKYAKSQSLGIICHFCKRNSLPQYQATMPDGKLYNFCNSSCVAKFQALSMQSSPNGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKKLHCIVTYCEYCQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKFQDWYYKAARCDCCKSQGTLKERVQWRGEMKHFCDQHCLLRFYCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPTPNKEMKNKAVLCKPLTMTKATYCKPHMQTKSCQTDDTWRTEYVPVPIPVPVYIPVPMHMYSQNIPVPTTVPVPVPVPVFLPAPLDSSEKIPAAIEELKSKVSSDALDTELLTMTDMMSEDEGKTETTNINSVIIETDIIGSDLLKNSDPETQSSMPDVPYEPDLDIEIDFPRAAEELDMENEFLLPPVFGEEYEEQPRPRSKKKGAKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWKHWVKTRQLDEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPDSIYYLCLGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGSIFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACLRYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDIYDKDNYELDEDTD