wanglab/gogpt-training-data huggingface dataset:
Protein: Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (G5EB41)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- cAMP-dependent protein kinase
- Phosphodiesterase
- Guanine nucleotide-binding protein alpha-3 subunit
- Guanine nucleotide-binding protein subunit alpha
- Ras-like protein
- cAMP-dependent protein kinase
- Ras small monomeric GTPase RasB
- SGT1 and CS domain protein
- Adenylyl cyclase-associated protein
- Cyclin dependent kinase inhibitor Pho81, putative
Sequence:
MAFPGGELPEGRHSSESSGNNSGLSQETIRDDGRRYGRIVPSGRSISPHSKDDGSDRLELPAPRPPSLGAPNDLYTSMFSWGSPDISPTDVRKNQGFGSHRKALAVLGNDDPGPPPINNPSPRVNTNYGDYFQHDPQGTLSYSPRLGTGDAHGTFFHDHSEHEASPATATFRPGTGRTLASDAPDLDYNGDHRRPSVASATTVSSQGSKSSTSGLFRKKLQGFFGDDPNASDSKQDHDGHHSSGSKPSSIDYFRSRQRADSEGSRRPSDGVQDDAHQPGRPRTPLPSSDITPWEYQRYNDIPQLGEAPVREAPTALDRHRIGSQGASSTSRDPTRRHFSGHRHSRSKEEKANAAGDLAGYPDRPSTGRDDFSVGLRPSRDGSLGFRPAANSSINLAGRSTSPTPSLQSFYTKDSGQGSPGAPSSKRSFLGKLRRPNLKHFPGSKGPTDAIRGTSKLARRDASPGRRGRQGSLEGAPSKGAENGEHERKKDGKGLGIATGKLRGRRGAGHETPIGKETNPSEAPGVWALDTDLSHMEGIVQPAADDGDKTNEGKTVRHDEKRLGDQLGAGNWDAPESWHVKRQRNEVLAKVPKMTNDAARTIAEPDGVPYFIRVFRIDGTFATLSNGLHATVADVLLSLGKKSFLTDHLNNYEIVMRKNDISRQLDPNEQPILMQKKLLEQIGYTEKDRIEELGREDHSYILRFTFLPTKLSGYSSLEGEPGFSKNQKFSHVDLQGRSLVTIPIALYKKAPEIISLNLSRNLELDVPKDFIQGCINLREIKYIGSEALRLPPSFSLASRLTYLDVSNNFLDQLDHANLDRLQGLVSIKLANNRLTKLPDYFGNFKSLRSLNIASNNFQVFPEFLCNLKSLVDLDISFNNISELPNIGNLTSLERLWMTNNGFRGPFGESIKDLVNLKEIDARFNEIVNIDSLTLLPRLEQLLIGHNSVSKFRGSFPKLRNLVLDHCPVTQFDIDAPMPTLTSLNIASAKLVQFRDTLFDSLPNLTKLILDKNHFMSMSPHIGKLRKLEHFSMAKNPLSSLPPSIGCLTELKYLNLRECNLRRLPQEIWYCLKLETLNVSSNVLDSFPKHGGPPPQLPGEATAGTTPAMTPGGSVTPSYDDLGTVEEQETRRPSQASGSAPSGSSPGGGSTRKPSVASSLSQGGRKVSTASKFAEGSPSSRKDSNFSQHVATTFGGSLRNLYLADNRLEDDVFRELSFIPELRIVNLSYNVLNEIPPGLLKRWPLLTELYLSGNELTSLPSDDLEEGSSLKILNINANRFQVLPAELCKVSKLSILDVGSNYLKYNVSNWPYDWNWNWNRNLKYLNFSGNKRLEIKPNVSSLGSQPPNGADLTDFNSLTHLRVLGLMDVTLTTSNIPEENEDRRVRTSASLAGSLAYGMADFLGRSEHLSIIDMIVPRMRQDNVETVVGMFDGQPSSTGGSRVAKFLHENFLHTFSAELKRLRRDEQETPLDAFRRTFLTLNRNMAFACYKSIDQDVRLFQEDSSDQKKVRLNKEDLQSGGVATVLYLNNTDLYAANIGDAQAILVKSDGSMRYLTRNHDPAEAGERARIRAAGGFVSRNGRLNDYLPVSRSFGYFNLMPAVIAAPHTMHVSLTEQDEMIILASKELWDYVTPDLVVDVTRAERRDLMVAAQKIRDLALSFGANNKLMVMILGVGDLRKRERRPPRFPSMNSFSQVDDSILPSPKRTKKPRDMPGDSRLARFDYVDAPTGELAIIFTDIKQSTGLWETCPDAMRSAIQIHNDILRRQLGIIGGYEVKTEGDAFMVAFSTTTAALLWCFNCQYQLLEAEWPTEILEQPQCQVQFDMENNIIFRGLSVRMGIHWGEPVCEKDPITNRMDYFGPMVNRASRISAVADGGQIFVSSDFMNDMQRNLELFADSERAASTGSEESYALDLGDNIRRELQQLNSQGFVIKDQGERKLKGLENPEPLYLIYPHALSGRLSTQDQMSGEESTPTTISQHSQLQIQTEAIWRLWEITLRLERLCGALEHPGEPRLDKPNSALFDIIKKHGGELADSSVVSLIEQQVTRIEVAISTLALRHMLRPFKPGDRLDDHAAPIGDVLQELRTQLAEYRALKEQIATNGAGITGASPSSTATDLHYTPDFHSSASSSSFT
Protein: Endoribonuclease YoeB (Putative mRNA interferase YoeB) (A0A0H2URH3)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSFKDHY
Protein: Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) (P10398)
Organism: Homo sapiens (Human)
Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
Interaction partners:
- Serine/threonine-protein kinase B-raf
- Dual specificity mitogen-activated protein kinase kinase 2
- GTPase KRas
- RAF proto-oncogene serine/threonine-protein kinase
- GTPase HRas
- Dual specificity mitogen-activated protein kinase kinase 1
- GTPase NRas
- 14-3-3 protein zeta/delta
- 14-3-3 protein beta/alpha
- 14-3-3 protein eta
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
Protein: Filamin B (D4A8D5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMHHKYHQRPTFRQMKLENVSVALEFLDHESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPRKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIESTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFAGQHISKSPFEVNVDKAQGDASKVTAKGPGLETTGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNSVELLVEDRGNQVYRCVYKPLQPGPHVVKVSFAGDAIPKSPFGVQIGEACNPNACRASGRGLQPKGVRIRETADFKVDTKAAGSGELAVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSIAVTWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDYNPDLVQAYGPGLEKTGCTINNPAEFIVDPKDAGNAPLKILAQDGEGQPIDIQMKSRMDGTYVCSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTFTVKYVPPAPGRYTIKVLFASEEIPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVHTKGAGKAPLNVQFSSPVPGEAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKINGLENRVEVGKDQEFAIDTNGAGGQGKLDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPYTVEASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPGILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGSYAVTYVPLTAGMYTLTMKYGGELVPQFPTWVKVEPTVDTSGIKAFGPGIEGKDVFREATTDFTVDARPLTQVGGDHIKAHIANPSGASTECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDAPIPNSPFKVAVNEGCQPSRVHAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGVHIPGSPFRVPSKDVVDPSKVKIAGPGLSSCVRACIPQSFTVDTSKAGLAPLEVRVMGPRGLVEPVDVVDNGDGTHTVTYTPSQEGPYIVSVKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSAYGVPASLPVEFAIDARDAGEGLLAVQITDQEGKPQRATVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQTGDASKCLATGPGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGQVHMPSGKKATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGHVTEAEIVPVGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGIPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPDSPYLVPVIAPSDDARCLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGLEAGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEIPEGYKVMYTPMAPGNYLISVKYGGPNHISRSPFKAKVTGQRLVTPGSANETSSILVESVTRSSTETCYSAIPKSSSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGKQQYNVTYVVKEKGDYVLAVKWGEEHIPGSPFHVTVP
Protein: Voltage-gated delayed rectifier potassium channel KCNH5 (Ether-a-go-go potassium channel 2) (hEAG2) (Potassium voltage-gated channel subfamily H member 5) (Voltage-gated potassium channel subunit Kv10.2) (Q8NCM2)
Organism: Homo sapiens (Human)
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF
Protein: Sugar transporter ERD6 (Early-responsive to dehydration protein 6) (Sugar transporter-like protein 1) (O04036)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar transporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Sucrose transport protein SUC4
Sequence:
MERQKSMEKGLLRKSLSIRERKFPNEDAFLESGLSRKSPREVKKPQNDDGECRVTASVFLSTFVAVSGSFCTGCGVGFSSGAQAGITKDLSLSVAEYSMFGSILTLGGLIGAVFSGKVADVLGRKRTMLFCEFFCITGWLCVALAQNAMWLDCGRLLLGIGVGIFSYVIPVYIAEIAPKHVRGSFVFANQLMQNCGISLFFIIGNFIPWRLLTVVGLVPCVFHVFCLFFIPESPRWLAKLGRDKECRSSLQRLRGSDVDISREANTIRDTIDMTENGGETKMSELFQRRYAYPLIIGVGLMFLQQLCGSSGVTYYASSLFNKGGFPSAIGTSVIATIMVPKAMLATVLVDKMGRRTLLMASCSAMGLSALLLSVSYGFQSFGILPELTPIFTCIGVLGHIVSFAMGMGGLPWIIMAEIFPMNVKVSAGTLVTVTNWLFGWIITYTFNFMLEWNASGMFLIFSMVSASSIVFIYFLVPETKGRSLEEIQALLNNSVQ
Protein: MB2w5 protein (P70241)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLDCMGAGGFVAHVESTCVLDDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISMILNEQESLIQRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTAPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: Small ribosomal subunit protein uS11B (40S ribosomal protein S14-B) (P0CT57)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P39516}. Nucleus {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS14
- Elongation factor 3
- Small ribosomal subunit protein eS27
- mRNA export factor elf1
- Small ribosomal subunit protein uS4B
Sequence:
MATNVGPQIRSGELVFGVAHIFASFNDTFVHITDLTGKETIVRVTGGMKVKTDRDESSPYAAMLAAQDAAAKCKEVGITALHIKIRATGGTATKTPGPGAQAALRALARAGMRIGRIEDVTPIPTDSTRRKGGRRGRRL
Protein: Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) (Q06806)
Organism: Mus musculus (Mouse)
Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Angiopoietin-1
- Angiopoietin-2
- Cadherin-5
- Platelet endothelial cell adhesion molecule
- Angiopoietin-4
- Receptor-type tyrosine-protein phosphatase beta
- Angiopoietin-1 receptor
- Nitric oxide synthase 3
- Leukocyte cell-derived chemotaxin-2
- Roundabout homolog 4
Sequence:
MVWWGSSLLLPTLFLASHVGASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSDPPLLLEKDDRIVRTFPPGQPLYLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQTDVIWKNNGSYFNTLDWQEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLMNLKPKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAPSGPISKYIVEIQVAGGSGDPQWMDVDRPEETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Protein: Protein transport protein SEC23 (A0A178VR60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}.
Interaction partners:
Sequence:
MAEFGELEAQDGVRMPWNIIPVATKKEQSIDSEVPVSAIYTPLKPLRSQSLLLPYSPLRCRTCRSVLNPYSVVDFSACNWGCPFCFNRNPFPLNYSSVADNNLPPELFPHSTTVEYLCDSFSSPSPPVFLFVVDTCLISEELDFLKSSLFQALDLLPDTSILGLITFDSLVRVYELGFPHCTKSYFFHGNKDCTKDQLLDQLSFFVKNPKPSSGVIAGARDGLSSDDIARFLLPASDCHFTLHSVLEELGNSPWPVAADHRPARCTGVALRIAASLLGACFPGSAARIMAFIGGPSTQGPGAIVSRELSDPIRSHKDIDKDSAMYYHKAVEFYEMLAKQLVHQGHVLDVFASSVDQVGIAELKVAVEQTGGFVVLAESFGHSVFRDSLKRVCQSGENDLGLSSCGIFEINCSKDIKVQGIIGPCASLEKKGPLCSDTAIGQGHTSAWKMCGLDNNTSICLVFEIAKIDTADVVLQSQSNQFYFQFLTYYQHSNGQTRLRVTTLSRRWVMGTESLQELSNGFDQEAAAVVMARLISSKMETQPEFNPQRWVDKALINLCTWFGDYQKGNPSSFSLSSQLSIFPQFVFHLRRSQFVQVFNNSPDETAYFRMILYRENVSNSVVMIQPSLISFSFHSPPEPILLDVASIAADRILLLDSYFTLVIFHGSTIAQWRKAGYHNQPEHQAFGHLLQSPRDYADTIMSERFPTPRLVICDQYGSQARFLLAKLNPCDGDAHFSGQSNVFTDDVSLSVFLDHLRRLIVH
Protein: GDSL esterase/lipase ACHE (EC 3.1.1.-) (Acetylcholinesterase) (AChE) (B4FZ87)
Organism: Zea mays (Maize)
Function: Esterase that can hydrolyze acetylthiocholine and propionylthiocholine in vitro. Substrate preference is propionylthiocholine > acetylthiocholine. Possesses extremely low activity against butyrylthiocholine.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- aldehyde oxygenase
- aldehyde oxygenase
Sequence:
MATAATATAGSRAAVLLLLSLALALALRPSDAGAGGDCHFPAVFNFGDSNSDTGGLSSLFGAAPPPNGRTFFGMPAGRYCDGRLVIDFIAESLGLTHLSAYLNSIGSNFTQGANFATAGSSIRRQNTSLFLSGFSPISLDVQFWEFEQFINRSQLVYNNKGGIYREILPRAEYFSQALYTFDIGQNDITSSYFVNNTTEEVEAIIPDLMERLTSIIQSVYSRGGRYFWIHNTGPLGCLPYALLHRPDLAIPADGTGCSVTYNKVAQLFNLRLKETVASLRKTHPDAAFTYVDVYTAKYKLISQANKLGFDDPLLTCCGYGGGRYNLDLSVGCGGKKQVNGTSVVVGKSCENPSKRVSWDGVHFTEAANKFVFDQIVAGALSDPPVALRQACHSRGQ
Protein: Excretory canal abnormal protein 6 (Q9TYU9)
Organism: Caenorhabditis elegans
Function: Constitutively active protein required for microtubule and F-actin growth, structural maintenance and organization during excretory cell tubulogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25771894}. Note=Localizes to leading edge F-actin and microtubules. {ECO:0000269|PubMed:25771894}.
Interaction partners:
- Formin-homology and zinc finger domains protein 1
- Myosin regulatory light chain
- Profilin-3
- Abnormal cell migration protein 10
- Profilin-2
- DH domain-containing protein
Sequence:
MTSDTIRQTLDELLLDKNGGSSNEARAFFLSQIIDQLKLISSQTDAERQLQKLQLKDPNDNIVKATPPPPPPPPPLISILQQAPPPPPPPPPPTLKAPPPPPILGLKTPSKSLKTPTPRPKECPTSFLPKKEKKTKTRTVQWSKINASVVQDDSVWGKLAKASNVDIDFDLLDNFFGIESLAVSGAAEVVKKSTRKDAHVELLTAKRSQNVAIMLKQFKNIDELIDDVSQNKPVAEIDALQNLFGMLPQSEEEEALRRYTGDISLLSPPSSFFYRLVQIQFYRLRIETQIFLSDFSRLMRELAPNVEILIRTSQEILTSPTLPRLLLIFVNMGNYLNGNNSQGNAFGFTLNSLWKLIDLKGNKQEFSLLHLLVTCEPDLVAHLQEELSTLKDASQISFDEIKISLKTLRDGRCKLEKQLETCSGASFTQFLELIKIDCKFELDEFGANYDKLTELQYQLADYFCENRNTFQLDECLKIFNFLMNRLQQTLKEHVTRETRKLKKEEKKETQTTRECEKTMKKPEKIDLFDALTASNGGPESPRKRAAGILDMRQKLGNVRIRKLRDVTTLESSFTPPPPPPLESPTDSTSSKENESVKPAKTSTNYEMCNDLESYITSLTRKRASHLPKAPPKEEPKLPEVLPEKSKIALKIEKIPEKIDKPPLPQAAPIIPKLPQKSIKAPSTVTTRSKVPPPTAAAAVRIVSVTTTTTPTKTAELRKPGARSPKTTVATVPKVTVVPVSRVPVAPSTPLSRRMSAPVVRKPTMTAEKKREITMKPSVSTSARPSLINTSSHPMVRSPLPKMSVLEKPKPLRITRPTVIPQSPTVTSSARPSGLRQPAKPKWV
Protein: Cytochrome b-c1 complex subunit 10, mitochondrial (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c oxidoreductase subunit 10) (Ubiquinol-cytochrome c reductase 8.5 kDa protein) (P37299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). QCR10 has a role in CIII assembly and RIP1 stability.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30598554}; Single-pass membrane protein {ECO:0000269|PubMed:30598554}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 8, mitochondrial
Sequence:
MAYTSHLSSKTGLHFGRLSLRSLTAYAPNLMLWGGASMLGLFVFTEGWPKFQDTLYKKIPLLGPTLEDHTPPEDKPN
Protein: Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) (Q9Y4B4)
Organism: Homo sapiens (Human)
Function: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Localizes in speckle-like nuclear compartments. {ECO:0000250}.
Interaction partners:
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Androgen receptor
- Nuclear receptor subfamily 5 group A member 2
- DDB1- and CUL4-associated factor 7
- Glucocorticoid receptor
Sequence:
MSDESASGSDPDLDPDVELEDAEEEEEEEEVAVEECDRDDEEDLLDDPSLEGMCGTEHAQLGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKNLASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLEFLPEEIALRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEDDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPPPEALPADNKPEEVQPRFFKVHILNDEHKTMASRAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSKIQRDLYTQFMDRFRDCGSSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKESLANEQDLDVEELGSAGTSARCPPQGTKGKGEDSTLASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCPPGTEGQGAQKWVRNISYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQVSLNVKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKVPEDGRMAASGSQGPSCESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTNAALPGPPAQLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPPAAQESSRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSIYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK
Protein: Spindle assembly checkpoint serine/threonine-protein kinase bub1 (EC 2.7.11.1) (Checkpoint serine/threonine-protein kinase bub1) (O94751)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3.
Subcellular location: Nucleus {ECO:0000269|PubMed:15509783, ECO:0000269|PubMed:15525673, ECO:0000269|PubMed:22521786, ECO:0000269|PubMed:22660415, ECO:0000269|PubMed:9864354}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15509783, ECO:0000269|PubMed:22521786, ECO:0000269|PubMed:22660415, ECO:0000269|PubMed:9864354}. Chromosome, centromere {ECO:0000269|PubMed:9864354}. Note=Recruited to kinetochores and centromeres during the early stages of mitosis when cells start to form a spindle and kinetochores are unattached, when spc7 is phosphorylated by mph1. {ECO:0000269|PubMed:22521786, ECO:0000269|PubMed:22660415, ECO:0000269|PubMed:9864354}.
Interaction partners:
- Mitotic spindle checkpoint component mad2
- Spindle assembly checkpoint protein bub3
- Kinetochore protein ndc80
- Separin
- WD repeat-containing protein slp1
- Outer kinetochore KNL1 complex subunit spc7
- Kinetochore protein nuf2
- Cyclin-dependent kinase 1
- Spindle assembly checkpoint component mad1
- Mitotic spindle checkpoint component mad3
Sequence:
MSDWRLTENVLDQNIPETKPRESKTRLEEIQRLALFQEELDIIEELDDPVDVWYRCIEWLLETRFLGMETVNKMLDDAIQYLERCRFALNDVRHLLIQLAKIKQSYETPDELQQAAKQFYQLASKGIGLELALFYEEYGSLLIRMQRWKEASEVFHAAVSREARPLVRLLRNAAEFSRAYDLHNAHPSIHDAPYSSPFPPPRIVLGSKPVSSSTLPSKPKSFQVFSDASSSRDSQNASDLPQAKSLESEANTPNLPLLYDKSSGKRVEYSAFNFLALYENGEERSMEECRAQRYLSSIQPNTAASFPKVVPKNEISVHHDSSSSNVSPIYKNPVAEQSDTPTRSLPKNYAYVAKSTSPELKVFDTVMPVALSPKPAQKPPSPTIHTKAALADILDIFNQPLRSESLEKSSKSPISAQSSYLGTPLKNDENSSNSGATSLTGRSQEEHLDFIPSLTPSKNYPSKIYSPNKNLDFSHTASKAETYKNSNELENVKREQPFSELLPSTLQEETATGTTSTTFANAKRRPEDSNISPTNPKKLHTLPRSPQYSTVDSNSVLSPAMPKGYMFVNENQSMKHESSVSNPVATIPHENGKHDFGQLSPIEHKPFFPKNDDELPGPSGYLTMPYEEAMASLSNLPTLINPLDQSLRDLLFQVLRPSLLRDKDYHEHETSFALVEHIESFVSKIKPKAGGPGRRRSSNRHSLDGPEFHLFYPPNTNLSVISKLGQGAFAPVYLVKSKIETENGDVSQGGAENNESKLFALKIETPPSCFEFYLTRQAMTRLKGLRETNSILPVHQLHMFHDTSHLLMDYRPQGSILDLVNSMHNSTFSSSGMDEILVVFFSIEFLRIIEALHTHKIIHGDLKADNALLRLETVADSEWSPIYSPEGLYGWSFKGIYLIDFGRGIDLSLFEEKVKFIADWDTDLQDCIEMREGRPWTYQIDYHGLAAIIYTMLFGQYIETRIEVINGQRRQVLTQRMKRYWNQDLWHRLFDLLLNPTLHVSEENLPMTEELSKIRIEMEEWLVNHSTGGSGLKGLLKSIEKRKI
Protein: Gamma-glutamyl hydrolase 1 (AtGGH1) (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase) (Q9SYL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role in folate stability and intracellular folate content.
Subcellular location: Vacuole {ECO:0000305|PubMed:21070406}. Secreted, extracellular space {ECO:0000250}. Secreted, cell wall {ECO:0000250}. Note=Extracellular or cell-wall bound.
Interaction partners:
- Folylpolyglutamate synthase
- Folylpolyglutamate synthase
- Folylpolyglutamate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase 1
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
- Probable ubiquitin-conjugating enzyme E2 24
- Gamma-glutamyl hydrolase 2
- Probable gamma-glutamyl hydrolase 3
- GTP cyclohydrolase 1
Sequence:
MIDNNCLYKEELNRNSYSGLAKEASESILLPSESGFDGSRSPVCSSPDPNLNYRPVIGILSHPGDGASGRLTNDTSSTYIAASYVKFAEAGGARVIPLIYNEPEEVLFQKLELVNGVIFTGGWAKKYDYFEIVKKIFTKALERNDAGEHFPVYGICLGFELMSIIISQNRDILERFDAEDNASSLQFVDNVNNDGTLFQRFPPELLKKLSTDCLVMQKHKYGITPANFQANPALSSFFEILTTCIDENSKTYVSTVKAKRYPITGFQWHPEKNAFEWGSSAIPHSEDAIQVTQHAASYLVSEARKSLNRPESQKVLSNLIYNYKPTYCGYAGRGYDEVYIFTQPRSRF