wanglab/gogpt-training-data huggingface dataset:
Protein: Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) (P85973)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00491}.
Interaction partners:
- Adenosine deaminase
- Guanine deaminase
- Adenine phosphoribosyltransferase
- Xanthine dehydrogenase/oxidase
- Adenosine kinase
- 5'-nucleotidase
- Uridine phosphorylase
- Hypoxanthine-guanine phosphoribosyltransferase
- Uridine phosphorylase
- Bifunctional epoxide hydrolase 2
Sequence:
MENEFTYEDYQRTAEWLRSHTKHRPQVAVICGSGLGGLTAKLTQPQAFDYNEIPNFPQSTVQGHAGRLVFGFLNGRSCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFNAWKQMGEQRELQEGTYIMSAGPTFETVAESCLLRMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYNNLEKASHQEVLEAGKAAAQKLEQFVSILMESIPPRERAN
Protein: Actin-like protein MamK (EC 3.6.1.-) (Magnetosome cytoskeleton protein MamK) (Q6NE59)
Organism: Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)
Function: Protein with ATPase activity which forms dynamic cytoplasmic filaments that are involved in sorting, concatenating and/or correctly positioning of magnetosomes in the cell. Not absolutely necessary for assembly of short chains. Filaments grow from the both cell poles towards midcell, and are probably disassembled at the other end of the cell, a process known as treadmilling. Polymerizes in the presence of ATP, GTP or a non-hydrolyzable ATP analog. Required for correct segregation and positioning of magnetosomes following cell division.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:17601786, ECO:0000305|PubMed:20487281, ECO:0000305|PubMed:22026731, ECO:0000305|PubMed:22586444, ECO:0000305|PubMed:24272781}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17601786, ECO:0000269|PubMed:20487281}. Note=Tagged protein forms straight lines extending along most of the cell associated with its inner curvature, in the correct position to be filaments that are seen associated with magnetosomes (PubMed:17601786, PubMed:20487281). The exact pattern depends on the N- or C-terminal location of the tag and the length of the linker to the rest of the protein (PubMed:20487281). Individual filaments are 3-6 nm in diameter and 0.5-1 nm in length and occasionally form bundles. Filaments are in close proximity to magnetosome membranes. Most are near midcell, however some extend to nearly the cell pole; they are not seen in a deletion mutant (PubMed:20487281). Filaments do not colocalize with FtsZ-like (also called FtsZm) foci (PubMed:24272781). {ECO:0000269|PubMed:17601786, ECO:0000269|PubMed:20487281, ECO:0000269|PubMed:24272781}.
Interaction partners:
- Magnetosome-associated protein MamJ
- Magnetosome formation protease MamE
- Probable membrane transporter protein MamO
- Magnetosome protein MamH
- Magnetosome protein MmsF
- Magnetosome protein MamM
- Magnetosome protein MamI
- Magnetosome protein MamL
- Cell division protein FtsZ
- FtsZ-like protein
Sequence:
MWIDLLARERSDKMSEGEGQAKNRLFLGIDLGTSHTAVMTSRGKKFLLKSVVGYPKDVIGLKLLGRPYVVGDEAFEMRSYLDLRYPLQDGVLSEISDRDIEVARHLLTHVVKSAEPGANDEICAVIGVPARASGANKALLLKMAQEVVHTALVVSEPFMVGYGLDKLNNTIIVDIGAGTTDICALKGTVPGPEDQVTLTKAGNYLDERLQNAILERHPELQMNTNVACAVKEQFSFVGARGEAATFEFRAAGKPVRCDVTESVKIACEALMPDIIESIEILLRSFQPEYQATVLQNIVFAGGGSRIRGLAAYVKDKLRPFGNADVTCVKDPTFDGCRGALRLAEELPPQYWCQLGDVSGQ
Protein: At2g20690/F5H14.34 (Lumazine-binding family protein) (Putative riboflavin synthase alpha chain) (Q9SKU8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 6,7-dimethyl-8-ribityllumazine synthase, chloroplastic
- Monofunctional riboflavin biosynthesis protein RIBA 3
- Monofunctional riboflavin biosynthesis protein RIBA 2
- Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic
- Bifunctional riboflavin kinase/FMN phosphatase
- Riboflavin biosynthesis protein PYRD
- Flavin mononucleotide hydrolase 1, chloroplatic
- 5-amino-6-
- Purple acid phosphatase 3
- Purple acid phosphatase 17
Sequence:
MMAARTHCINLIPKVCLPQSFRTGESVTNLRFDCVSKSSKLSLKTSCGRSRTHHRRQNLSIRSVFTGIVEEMGEVKDLGMADHGGFDLKIGARVVLEDVKLGDSIAVNGTCLTVTEFNAEEFTVGLAPETLRKTSLEELKKGSPVNLERALQPVSRMGGHVVQGHVDGTGVIESMEVEGDSLWVKVKADKGLLKYIVPKGFVAVDGTSLTVVDVFDEESCFNFMMIAYTQQNVVIPTKKIGQKVNLEVDIMGKYVERLLTSGGFSKGKENI
Protein: Rab family protein (Q8KC98)
Organism: Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Interaction partners:
- Chaperone protein HtpG
- Lipoprotein
- Transcriptional regulator, Crp/Fnr family
- Chloride channel, putative
- ATP synthase subunit c
- Hypoxanthine phosphoribosyltransferase
- WD-repeat family protein
- DoxX family protein
- Isoprenylcysteine carboxylmethyltransferase family protein
- YbhB/YbcL family Raf kinase inhibitor-like protein
Sequence:
MSDLDVIRQIEQELGMQLEPVDKLKWYSKGYKLDKDQRVTAIGLYDCGSDTLDRIIQPLESLKSLSELSLSSNQITDISPLASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDISPLASLNSLTGFDVRRNPIKRLPETITGFDMEILWNDFSSSGFITFFDNPLESPPPEIVKQGKEAVRQYFQSIEEARSKGEALVHLQEIKVHLIGDGMAGKTSLLKQLIGETFDPKESQTHGLNVVTKQAPNIKGLENDDELKECLFHFWDFGGQEIMHASHQFFMTRSSVYMLLLDSRTDSNKHYWLRHIEKYGGKSPVIVVMNKIDENPSYNIEQKKINERFPAIENRFHRISCKNGDGVESIAKSLKSAVLHPDSIYGTPLAPSWIKVKEKLVEATTAQRYLNRTEVEKICNDSGITDPGERKTLLGYLNNLGIVLYFEALDLSEIYVLDPHWVTIGVYRIINSSKTKNGHLNTSALGYILNEEQIRCDEYDPAKNNKFTYTLLEQRYLLDIMKQFELCYDEGKGLFIIPSNLPTQIDNEPEITEGEPLRFIMKYDYLPSTIIPRLMIAMQHQILDRMQWRYGMVLKSQDHEGALAKVVAETKDSTITIAIQGEPRCKREYLSIIWYEIKKINANFTNLDVKEFIPLPGHPDELVEYKELLGLEKMGRDEYVSGKLEKVFSVSKMLDSVISKEERNKERLMGDINIKLENIGNPTIPIHQQVEVNVSQETVQHVENLQGFFENLKADILREAELEIDDPKERKRLANELELAENAITKMDAAVKSGKNKLKPDVKDRLGEFIDNLANENSRLRKGIALVMNGAEKVQKLARYYNNVAPFFDLPSVPPVLLGKEKT
Protein: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-) (Q6N063)
Organism: Homo sapiens (Human)
Interaction partners:
- tRNA
Sequence:
MATVGAPRHFCRCACFCTDNLYVARYGLHVRFRGEQQLRRDYGPILRSRGCVSAKDFQQLLAELEQEVERRQRLGQESAARKALIASSYHPARPEVYDSLQDAALAPEFLAVTEYSVSPDADLKGLLQRLETVSEEKRIYRVPVFTAPFCQALLEELEHFEQSDMPKGRPNTMNNYGVLLHELGLDEPLMTPLRERFLQPLMALLYPDCGGGRLDSHRAFVVKYAPGQDLELGCHYDNAELTLNVALGKVFTGGALYFGGLFQAPTALTEPLEVEHVVGQGVLHRGGQLHGARPLGTGERWNLVVWLRASAVRNSLCPMCCREPDLVDDEGFGDGFTREEPATVDVCALT
Protein: Copine-A (Q7YXU4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for cytokinesis, contractile vacuole function and development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16343335}. Membrane {ECO:0000269|PubMed:16343335}; Peripheral membrane protein {ECO:0000269|PubMed:16343335}. Note=In starved cells it binds transiently and in a calcium-dependent manner to the plasma membrane and intracellular vacuoles. In some cells, the transient membrane localization is observed to occur multiple times in an oscillatory manner over several minutes. Also found to be associated to the plasma membrane, contractile vacuoles, organelles of the endolysosomal pathway and phagosomes.
Interaction partners:
Sequence:
MNLKPPTSKVELRIKCHKILDKDTLSKSDPRASVYEKDRAGQFRLIGKTETIQNQLNPEFKTPIVIDYRFEEIQVLKFEIHDVDKNDEDFIGDASCTLTSILSKPGQTVCLQLLTKSGKHAGSMTVIAEEIKNTLQTIKFNLIGKKFDKKDLFGAGCDPYLIISRKVPSTNTFVKIYESQVQKGTLNPVFSGIEMKLEELCGGDMQREIKFEFYDWDRIGKHDYIGEFHTNAQELLQPNQAFNVINSHKQEKKSGYKNSGTVSVSDAVIEREYNFLEYIMGGCQMNLIVGIDCTASNGDSNDPNSLHYKNAQGLNQYANAICSVGNVIVPYTTTPLIPVYGFGGIMPGQSEVSHCFPMTLNASNTLCCGVNGVLDCYYDNISKIQLHGPTYFAPLINMAARYASQGQSQSNQKYTILMIITDGEILDADNTIDAIVKSSGLPLSIIIVGVGNANFTNMNILDGDDAALQSGGVRAERDIVQFVAMRDYLNRPNELAAEVLREIPTQFLSFMKKYKFRPNPPPPPPPVIIGAPPQYDNPTTTTTATSPSTGIDLNKGSNVGLNLTKTESSPSPSGGAGIDLNKGSVVDITKGVSNVSLEKN
Protein: CID domain-containing protein (Q38C68)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDTFQEKLDALQKQSKEQIAAAIAAMKGACREGAEPVRVAVAIGSRLTPLNILSSFPVVCLLDAMVMAKGDETVAQVMKEFWRISPSLFVNYATTDEGLRDKVVRVVQRWGSKKLIEPPMCEKLLGAIKGIRPDEASSAEEGKGEKRSDEAQNGRKGAVFTRSEVSGFCAILHSCTKMIEKLPPHRASMYMEVAQKEMSSHVPNRPALLFFQGLHAELGKELTLYNSNAVKNEHQLAQAVSGGPSAKEALGNLLDKLSKDHASPSLEAGDGKGHAFHVVRYITPLQSDICQRLSLARRAGFGDWYRRPKNEYHYPKRESNARKVFRAPAGAGPLVRTWFPSEQQWISENNMASLGLFRERDPDKERESSSLYAVARKRDRDC
Protein: Somatotropin (Growth hormone) (P10814)
Organism: Salmo salar (Atlantic salmon)
Function: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
Subcellular location: Secreted.
Interaction partners:
- Growth hormone receptor
- Growth hormone receptor-like isoform X1
- Growth hormone receptor isoform 1
- Somatolactin receptor
- Somatolactin
- Pro-opiomelanocortin A1
- Growth hormone 2
- Prolactin receptor
- Pro-opiomelanocortin A2
- Appetite-regulating hormone precursor
Sequence:
MGQVFLLMPVLLVSCFLSQGAAMENQRLFNIAVNRVQHLHLMAQKMFNDFEGTLLPDERRQLNKIFLLDFCNSDSIVSPIDKLETQKSSVLKLLHISFRLIESWEYPSQTLTISNSLMVRNSNQISEKLSDLKVGINLLIKGSQDGVLSLDDNDSQQLPPYGNYYQNLGGDGNVRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL
Protein: E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CHIP) (Q86DT6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
LKRWELCCQDSRRALDIDGNLLKGHFFLGQGLMEIDNFDEAIKHLQRAYDLSKEQKQNFGDDITLQLRLARKKRWNVMEEKRIQQEIELQSYLNGLIKGDMESRLANLKLNGNVHDEQLKDKQQEIEQECDDHIKELNNIFSKVDERRKKREVPDFLCGKISFEILTDPVITPSGITYERKDIEEHLQRVGHFDPVTRAKLTQDQLIPNFSMKEVVDSFIA
Protein: SNF7 family protein (F4KC57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGNLFVKKPQITEVDRAILSLKTQRRKLGQYQQKLEKVIEAEKQAARDLIREKRKDRALLALRKKRTQEELLKQVDQWVINVEQQLTDIELTSKQKAVFESLKQGNSAIKAIQSELDLDDVQKLMDDTADAKAYQDCENLYNLFCRAFVFDDSIYISECQELNAILGEKLSAEDEEDILAEFDNLESQLIVDEMPEVPTKESEESEKLDLPDVPTKTPVASNAEITPAESATKTKVLEEPLPA
Protein: Universal stress protein Rv2623 (USP Rv2623) (P9WFD7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.
Interaction partners:
- Alpha-crystallin
- Hypoxic response protein 1
- DNA-binding transcriptional activator DevR/DosR
- Putative NAD
- Uncharacterized protein Rv1738
- Uncharacterized protein Rv0080
- Ferredoxin
- Universal stress protein Rv3134c
- Putative NAD
- Probable nitrate/nitrite transporter NarK2
Sequence:
MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAPVLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVVVRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT
Protein: Protein angel homolog 2 (Q5VTE6)
Organism: Homo sapiens (Human)
Interaction partners:
- Target of EGR1 protein 1
Sequence:
MEAWRCVRKGYGHCVVGRGRYPMFPHHSRSLGRDWTTPWENLQRCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPCLFESRTQFQYCNWRPDNLSQTSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKTKILGDKNVDPKCEDSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRPDISLLDRDNVGLVLLLQPKIPYAACPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFSLSSVYSHYFPDTGIPEVTTCHSRSAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL
Protein: AP2 domain transcription factor AP2-EXP (Q8IKH2)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEDNNMNNEQKFNPNMLGMENNVSQEPAAETVVVEPKKKVGRPRGASSNNKVIKKEEKVSTSSSGYPGVSWNKRMCAWLAFFYDGASRRSRTFHPKHFNMDKEKARLAAVEFMKTVENNGRKKSGKGKGGRSKSKQLNDEHFNALHNSDLGNSMNGMNAHNNLHMQLMSMNPAFYMQSLNRNFNMSANERNNMFNSLNNHSGLSGPLKNMQDHNELYMQNQVFNNMHLLNNSNSSLNNNRNNNSNNNNNSSNSHNNSSNNLHYLNELIFNSNLFHGNNMGYHEGNVNTGVSDLLNLDDNVGLHNKDVENLMNVLFRQNYNMNMNISNIDKHYLQGSNILMNGPQGNNNNMNNSNSNNNNNSGSNNNSNNNNNNNNTNNNNNSGSNNNSNNNNNMNNNKNNNNNNNNSNSGNSNSSQNQHMYLSSHNNDIFENNNNNSNSGNNDSNNNNQSNISNFYDYNFDLYRGNVSPNIMDMVHRMNNNMKDGKNLDSLNDDIGNDLNFRLHENSAWINQLRQSHNNLCNNINNNHCDLCHTTSPDHSLKGQMELSKRKKTTSNINNRKNDLLEDSVNSFDLNMPCSCSSHLRNQKNHFCVYYNQSNSSSQNENYKNYLNWNPNSNNNLINNSIDKNDTPLDNSNGNSGRNLGDSNLLCISQNNNGTSSQSTNPKHLSQTIDMNQKQSSHTSQYSNNPNLQDIQNQFSYQNQPNINMDMHSQLNLIKQNCNYSPKCINNNKKKSTTGTSKDSTRKLLSSHSLSMPLEQQHQSSKKNNLSSSFIENNLCTKLNSIINFEWINNDLKMNLNGNKSNSYDNSES
Protein: Mitochondrial 3' processome subunit 3 (A0A120KVW2)
Organism: Trypanosoma brucei brucei
Function: As part of the mitochondrial 3' processome (MPsome), involved in the maturation of guided RNA (gRNA) precursors.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:26833087}.
Interaction partners:
Sequence:
MKKAWAQLERVLQPSSSRVNRALITQQLEALYALPINCEAACRWEDAQRLFLRCNGHRPYYAGIMDQSTDNRLAVASFEENMLALQQRGLVCTTVGDKAPPCVVGGQTSRGLCRRSSIVCVNVGSCADLDLNMHEDCDETLLTLLHGVVVPYLHFRIVYGTGVSPPLVPRAPGPAICGASHDLSLQNELHMDSCVALLHPRGLCSSNCNNKAYRTAATLVRGAVSLATSDTLLHQRQDGCFTLHPDAMKLGSPRLFALQLWWNKEVGPVIQRGVEQSVKTDEVLSGAWIEVARKRVEELVERGGDDLPQPLRNMTRDDVAAFAADATLCWTLSAFDCNYKRLGPAQPACRLQFSEEARLSMALELMQTVKASLVKQPTGIPISELSATVCWPAASAWIGEKSLTEALTQFPAHFNVVNVEGKLVVMHGHLTGPSDNVTAEEVSEWLAAGHSEGLQKPCVAASPSDLTFHRETDLVVRAVAFLRKRHFGNVPVTYGELCGALLPKNNGKNDGDSDTLLNVLLRYDVLAADTAKGDSSINIQCGLRDGDAIRLSVREDRALRALEAFRTTSRSAFQLYTEAIEPFLTCCRGAMRENGSCVVPLTLLERWLQVERLSLQSKELLDILRSAEGPYRIDEELCNVVLTNHTAKGEVLTPAFSLPATPPPPPPPAVSSRLTFEAQISRVLKTQRPDRLLHFVQTILHAVFDLILPHVSAPSGVPVRMLMRRIRWGSFVVTLGSLTSFVEAFDGLFFEVLSNASSHGEEKRDDVDLIVSAYKGPVSPWLLYARLIVRLFPADVDIPLGLIAEALSWSSRFAPMFGDLPSLLRRVGRQCRNGQLLAKVEMVRPVCDQDDACLWELLAKIRREAHLHHLERSSGETGQYVLLSETELYAYLPNDVKGERWNSTVKEEGARCLATMAVHRLPHFFEWHVDNTDTTTRYVRVVLPFSTPPTGVVCFVEEYVCPLLRQHKQTTIAELDEQLGWSHGAFDAHPAGSQAAGGTPSATSLCGLLRRYVESMHSPKIILEPQETTLSPLHHHVHVMPNSAVYTSPEDMLLLLNGLRISNEGITRVLPTHKPVSLFELISQQLDLHQPFREGLTTLERGSRWNVMLACESDSMDDCLQELDNCTGDILVWCEG
Protein: Protein SMAX1-LIKE 5 (AtSMXL5) (Q9LU73)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function in a transcriptional corepressor complex.
Interaction partners:
- F-box protein MAX2
- Transmembrane protein
- Probable esterase KAI2
- Glycine-rich protein
- Leucine-rich repeat receptor-like protein kinase TDR
- ATP-dependent Clp protease adapter protein CLPS1
- Probable glucan endo-1,3-beta-glucosidase BG4
- Protein SIEVE ELEMENT OCCLUSION B
Sequence:
MRTGGYTIQQTLTTEAASVLKHSLTLARRRGHAQVTPLHVAATLLSSRTSLLRRACIKSHPGFSTNYQFAPSRLQHHHHHNQNHPLQCRALELCFNVALNRLPTVPGPMFHGQPSLANALVAALKRAQAHQRRGCIEQQQQTQTHPQTQQTQLLAVKVELEQLVISILDDPSVSRVMREAGFNSTAVKSCVEDCSVSSVFYGGSAVGVFSSPNSPDQQQQHHNSINRLHHYQNPKDFNFINPNFPLWQTHFLNQSPDQNPLLLSSSASHHHQQQRLREIDLKLVVDVLMRKKTKKKNPVIVGDSISFTEGFVSELMAKLERGEIDQTGELKQTHFVKFHFSPMASKFMRREDVELNIKELRKKVLSLTTSGKNAIIFTGDLKWTVKEITNNNSGGINEISSSYSPLDHLVEEIGKLITECNDDGDDDDCKTRKVWVMGTASFQTYMRCQMRQPSLETLWALHPVSVPSSANLGLSLHATSGHEARNMSTVNATKSLSGYDKAEEEETISHVLSCCPECVTSFDREAKSLKANQDKLLPSWLQSHDADSSSQKDELMGLKRKWNRFCETLHNQTGQLSMMGNYPYGLPYGSSHESSKSTSLIDSLGLKPNQRATNSIAKFRRQNSCTIEFDLGGNEHEKGESINEAEDDKGNETVTLDLGRSLFRSDSVTDTRLKLSALVKALEESIPRQTVTMRLIAESLMDCVSKKKDSWIIIEGRDTTAKRRVARTVSESVFGSFESLVHIDLKKKGNESKASPATLLAYELKNPEKVVFLIEDIDLADSRFLKLLADRFEDKRRIKTGIDHRQAIFILTKEDSRNVRNRDSVLQIGLEITAQSPGKKRKPESDLSIENGFWMKKEVCSRQSSFNSSYLDLNIKAEDEEVEGEISPISSDLTGEEETEFSSSSNFLNRIQNRFVLNRSCEPGIEKGMITAAFREIFPEREEGGGVRFSVEDKLVEELYGIQNGAFERWLKEVFQTGLLTVKKGGKKDTGVIRMVFGGIVDNKGYGGGVGGYMATFLPNKVQVSKFE
Protein: Acrosin (EC 3.4.21.10) (53 kDa fucose-binding protein) [Cleaved into: Acrosin light chain; Acrosin heavy chain] (P08001)
Organism: Sus scrofa (Pig)
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Interaction partners:
- ACD shelterin complex subunit and telomerase recruitment factor.
- Boule homolog, RNA binding protein.
- Spermatid nuclear transition protein 1
- Zonadhesin
- Acrosin-binding protein
- Testis expressed metallothionein like protein
- Izumo sperm-oocyte fusion 1
Sequence:
MLPTAVLLVLAVSVAARDNATCDGPCGLRFRQKLESGMRVVGGMSAEPGAWPWMVSLQIFMYHNNRRYHTCGGILLNSHWVLTAAHCFKNKKKVTDWRLIFGANEVVWGSNKPVKPPLQERFVEEIIIHEKYVSGLEINDIALIKITPPVPCGPFIGPGCLPQFKAGPPRAPQTCWVTGWGYLKEKGPRTSPTLQEARVALIDLELCNSTRWYNGRIRSTNVCAGYPRGKIDTCQGDSGGPLMCRDRAENTFVVVGITSWGVGCARAKRPGVYTSTWPYLNWIASKIGSNALQMVQLGTPPRPSTPAPPVRPPSVQTPVRPPWYFQRPPGPSQQPGSRPRPPAPPPAPPPPPPPPPPPPPPPPPPPQQVSAKPPQALSFAKRLQQLIEALKGTAFSSGRSYYETETTDLQELPAS
Protein: Bacterial microcompartment shell protein PduA (Bacterial microcompartment protein homohexamer) (BMC-H) (Propanediol utilization protein PduA) (P0A1C7)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: One of the major shell proteins of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation (Probable). At least one of PduA or PduJ is required for BMC assembly; it must be encoded as the first gene in the pdu operon. Not required for structural integrity of BMCs, it is required to mitigate propionaldehyde toxicity. Controls diffusion of 1,2-PD into and propionaldehyde out of the BMC shell; residue 40 is particularly important for pore permeability (Probable). Overexpression of this protein leads to aberrant filaments that extend the length of the cell, cross the cleavage furrow and impair division. The filaments form nanotubes with a hollow center. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2. Edge residues (particularly Lys-26) are important for function and assembly of the BMC, and influence array formation by hexamers. Interaction with PduA allows encapsulation of at least PduP in BMCs. Probably also targets PduD to the BMC (Probable). PduA is probably the hub for binding multiple enzymes to the interior of the BMC; modeling suggests PduC, PduD, PduE, PduG, PduL and PduP are targeted to PduA (Probable).
Subcellular location: Bacterial microcompartment {ECO:0000269|PubMed:11844753, ECO:0000269|PubMed:12923081, ECO:0000269|PubMed:24747050, ECO:0000269|PubMed:25713376, ECO:0000269|PubMed:27063436, ECO:0000269|PubMed:28585808}. Note=The C-terminus probably faces the interior of the BMC (Probable). Modeling suggests the concave face (with both termini) is in the interior of the BMC (Probable). {ECO:0000305|PubMed:22927404, ECO:0000305|PubMed:25646976}.
Interaction partners:
- Bacterial microcompartment shell vertex protein PduN
- Bacterial microcompartment shell protein PduT
- Propanal dehydrogenase
- Bacterial microcompartment shell protein PduB
- Bacterial microcompartment shell protein PduU
- Bacterial microcompartment shell vertex protein EutN
- Phosphate propanoyltransferase
- Propanediol dehydratase medium subunit
- Propanediol dehydratase large subunit
- Propanediol dehydratase small subunit
Sequence:
MQQEALGMVETKGLTAAIEAADAMVKSANVMLVGYEKIGSGLVTVIVRGDVGAVKAATDAGAAAARNVGEVKAVHVIPRPHTDVEKILPKGISQ
Protein: Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Q9GRC0)
Organism: Patiria pectinifera (Starfish) (Asterina pectinifera)
Function: Suppresses the mitotic cell cycle in oocytes, forcing them to undergo meiosis II to produce haploid gametes. Acts as a MAPK kinase kinase (MAP3K) that acts upstream of MAP kinase in oocytes.
Interaction partners:
Sequence:
MPCDTADNWARYEGQDNAIMVARRGSVNSAFVTNSSQYHQAEDTNGNCFINARNDNWDNRDCNACVGHSDFSIDGVIGSGGFGSVFLGRYCGRRVAVKSVRQCSRNKEASRQSFQAEFNALLLRHDNIVSVLATTAYEDFDSGAFIIMEYAGRNLQQIVNDPGSSLSPTRRTKYALHIIRALHYTHSQGIAHLDVKPANVIVDSNTDVCRLADFGCSQRVSEGEGRDSFTSRSYLTGTFAYRAPELLRGRPPTTKADIYSYGVTLWQMLTRETPFAGENHHVVIFGVVAQNLRPSLPENANDAWYESLVTRCWEGRVADRPSAAEILLALERRTDDTENLPRDLKRRHGTT
Protein: PH-interacting protein (PHIP) (IRS-1 PH domain-binding protein) (Neuronal differentiation-related protein) (NDRP) (WD repeat-containing protein 11) (Q8VDD9)
Organism: Mus musculus (Mouse)
Function: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Subcellular location: Nucleus {ECO:0000269|PubMed:17636024}.
Interaction partners:
- THO complex subunit 2
- Transcriptional regulator ATRX
Sequence:
MSRERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPTKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKVRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQDISPLDSMIQRLQQEQDLRRSGEAGVSNASRVNRGSVSSTSEVHSPPNIGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKSYRSEEKRKHLTVAKENKILTVSKNHAHEHFLDLGDSKKQQANQHNYRTRSALEETPRPLEELENGTSSSDEGEVLAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKVPKHKTKKPESSSDEEEESENQKQKHIKKERKKANEEKDGPTSPKKKKPKERKQKRLAVGELTENGLTLEEWLPSAWITDTLPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRPWNIGDRFRSVIDDAWWFGTIESQEPLQPEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDVECRSLIYKPLDGEWGANPRDEECERIVGGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRFSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEEEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCQELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNFKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTISKKRKKRNRSSSLSSSAASSPERKKRILKPQLKSEVSTSPFSIPTRSVLPRHNAAQMNGKPESSSVVRTRSNRVAVDPVVTEQPSTSSATKAFVSKTNTSAMPGKAMLENSVRHSKALSTLSSPDPLTFSHATKNNSAKENMEKEKPVKRKMKSSVFSKASPLPKSAAVIEQGECKNNVLIPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTSSGEVTHKKRGRKPKNLQCAKQENSEQNNMHPIRADVLPSSTCNFLSETNAVKEDLLQKKSRGGRKPKRKMKTHNLDSELIVPTNVKVLRRSNRKKTDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW
Protein: Uncharacterized protein Rv0093c (P9WM69)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- ECF RNA polymerase sigma factor SigC
- Anti-sigma-E factor RseA
- Manganese transport regulator
- Uncharacterized protein
Sequence:
MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATIDGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSAA