wanglab/gogpt-training-data huggingface dataset:
Protein: Basement membrane proteoglycan (H9G350)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKRSSTVLAALLALLLVATNDAARHRKYRQTYQDIDSDDDDTSDVQITVFPSEKEVRDGRDVSFECRARTSDNSVYPTVRWARVGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNTVEARATLSVVSYGPQEVSNGLRQAGQCMADEKACGNNECVKNDYVCDGEPDCRDRSDEANCPAISRTCEPNEFKCNNNKCVQKMWLCDGDDDCGDNSDELNCNAKPSSSDCKPTEFQCHDRRQCVPSSFHCDGTNDCHDGSDEVGCVQPTVVDPPQTNLQVPRGTTFSLTCKAVAVPEPYINWRLNWGPVCEPPRCLQTSEGGYGTLTIHDAQPVDQGAYTCEAINVKGRVLATPDCIVRVVDDPRPQPPQPPTAPPQRASCDTRGAVTPYPNNYGTCECKSQVTGPNCDQCKPGAFHLSEKSPEGCLKCFCFGVSNDCRSSGHYRTKDRLMFAGDAEGVTISDIEERTIDRNTPFSFFKTGYLTFDGTTDGVAKYWRLPQRFLGDKVTAYGGKMEFEIEFSGSGHHSSEPMVVLKGNQNILVHRVRNQEHVLRSDSPVRITVETYETNYEQLNGAAATREDLLMVLADLDAFLIRATHVAHQTSTSLGDVSWEIAVDRYTPDGLALEVEQCVCPPGYLGTSCEDCAPGYERSGYGPYLGTCVPIQPRHQQCGPGAVAPTAPAQGQCQCKASVIGPNCDRCAPNSFGLAPTNPQGCIPCFCSGVTQQCSASSYRRTSVSIDYARGDRDQLELTTSDSRQPYSPQTRAELSGQAIEFRSFEEARGQTLYWKLPEKFLGDKVTSYGGTLEYTFKFSGNGNSDQSADVILRGNDIALQYKHREPFYADRENKVQIKIIETSWQRVDGQQATREHLLMTLADLDTLLIKSTYNDDCTDSQLLSANLEFAEPYGQGLTAAEVEQCICPPGYVGTSCEDCAPGYSRTGGGLYLGLCEKCECNGHASQCDKEYGYCLDCQHNTEGDQCERCKPGFVGDARRGTPNDCQPEATRAPCHCNNHSPRGCDSFGRCLLCEHNTEGTHCERCKKGYYGDATKGSPYDCTPCPCPGASDCYLDNEGQVACRICPAGLQGRLCNECAPGYTRSNKPAGRVCEPIGQVTNEDITFVQKPHEVLRVRIMEPKRQIALPGDRVHWICQVTGYTTEKIHVEWTKVGEMSLPPNAKAYDGYLVLKGVEAENAGQYRCTATTITQYATDDALLTISKRISGRPPQPVIDPPHLVVNEGEPAAFRCWVPGIPDCQITWHREQLGGPLPHGVYQTGNALKIPQSQLHHAGRYICSAANQYGTGQSPPAVLEVKKPVIPPKVDPIRQTVDRDQPARFKCWVPGNSNVQLRWSRPGGAPLPSGVQEQQGILHIPRASDQEVGQYVCTATDPSDNTPLQSEPVQLNIRDPAPPQRGAAPQIDPPNQTVNVNDPAQFRCWVPGQPRAQLKWSRKDGRPLPNGILERDGFLRIDKSQLHDAGEYECTSTEPDGSTQLSPPARLNVNQPQAIQPQVDPPVQTVNEGEPSRIRCWVPGHPNIQLQFVKRGRRPLPAHARFSQGNLEIPRTLKSDEDEYICIATDPTTNRPVESNPARVIVKSPIRPIIDPAEQTVPEGSPFKIRCYVPGHPSVQLTFRRVSGQLNEDADENNGLLAVQRAELTDEGDYICTARDPDTGAPIDSTPATVHVTNAAAPPQVEARPPQHPVITPQTQTIPEGDPARIQCTVPGNPSAAQHLSFERVDGKGLPFGSSDDRGVLTIPSTQLQDAGEYVCLYSPENSPPVKTNPSTLNVTPEGTPPRPVATPPLLSVAPGSPARFNCVAHSDTPARIRWGFREENGPLPEHVNQDGDDIVISEAGDRNVGEYVCSATNDFGTGVADPVRLEVTEDQEPPTAVVEPRTWNGKPGERHQFRCITTGSPTPKITWTGPNGSPLPHDVTPLEPNILDFSNGRSELNGDYTCTASNPIGEASDHGNVNIGPSLTVKTNPPGPKLIVTVGEPLQVKCEAFGAPGDPEPEVEWLHDPGPERGDLPDDFKPVTISEQFIRHPNVGLGNAGVYTCKGSSAHATATKNIYIEVVEPSRIATVSILGGSSQWFDQGEKGELICTATGSSLVDRLEWEKVDDQLPTDVEEHNEPGLLHFPSFKNSYAGEYRCNGYRNNEIIASAAVHVHSSANADDEPKVEIEPPRVRVVSQGDNIVLKCSVQDPNARVLWWHATEDLVSFTNVANTNHLHLKHADLCDRGFYYCTLESTNYEVGQSANIVIVLQQGPIDAQIVKFDDKSDASFTCPIYSVPGSKVDWTYENGDLPSKAVPNGNKIEIKEFDDASAGTYVCKVSFDGNVVEGFVTAQMFVPDTIIQVLLEVSSESPQIGDRAWFDCKVTGDPSAVISWTKEGNDDLPPNAQVTGGRLLFTDLKEDNAGVYRCVAKTKAGPLQTRTVLNVGSGKRKRKHLGNRRGRRLRHRRRNAQNGPLSRKTRTTTKLFGSWF
Protein: Protein Tube (P22812)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. Also has a role in pupal pattern formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7635064}. Cell membrane {ECO:0000269|PubMed:7635064}. Note=Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei. Later in embryonic development protein is entirely cytoplasmic.
Interaction partners:
- Serine/threonine-protein kinase pelle
- LD20892p
- Embryonic polarity protein dorsal
- Protein toll
- NF-kappa-B inhibitor cactus
- Protein pellino
Sequence:
MAYGWNGCGMGVQVNGSNGAIGLSSKYSRNTELRRVEDNDIYRLAKILDENSCWRKLMSIIPKGMDVQACSGAGCLNFPAEIKKGFKYTAQDVFQIDEAANRLPPDQSKSQMMIDEWKTSGKLNERPTVGVLLQLLVQAELFSAADFVALDFLNESTPARPVDGPGALISLELLEEEMEVDNEGLSLKYQSSTATLGADAQGSVGLNLDNFEKDIVRRDKSVPQPSGNTPPIAPPRRQQRSTTNSNFATLTGTGTTSTTIPNVPNLTILNPSEQIQEPVLQPRPMNIPDLSILISNSGDLRATVSDNPSNRTSSTDPPNIPRITLLIDNSGDVNSRPNHAPAKASTATTSTASSNNLPMISALNISKGSRETLRPESRSSSSSLSKDDDDDNDGEEDGEEEYPDAFLPNLSNSEQQSSNNDSSLTTVTGTSGDNSFELTNDSSSTSNDDYACNIPDLSELQQ
Protein: Calicin (Q28068)
Organism: Bos taurus (Bovine)
Function: Possible morphogenic cytoskeletal element in spermiogenic differentiation.
Subcellular location: Cytoplasm, cytoskeleton, perinuclear theca, calyx {ECO:0000269|PubMed:7641791}.
Interaction partners:
- Cylicin-2
- Cylicin-1
Sequence:
MKLEFTEKNYNSFVLQNLNKQRKRKEYWDIALTVDHHVFFAHRNVLAAVSPLVKNLISNHDMKTTDELFITIDPNYLSPTTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRIHCNDFLIKSIRRANCLRYLFLAELFELKEVSDLAYSGIRDNFHYWASPEGCVHFMRCPPVIFGRLLRDENLHVLNEDQALNALINWVCFRKDEREKYFKKFFNYINLNAVSNKTLMYASNKLMGMENSSAHSTLIESVLVDRKQERPTSLLSYQRKGALLDSVVILGGQKAHGKFNDGVFAYIIQENLWLKLSEMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKETWCLAGKMSIPMDGTAVITRGDRNLYIVTGRCLVKGYISRVGVVDCFDTNTGEVVQCITFPIEFNHRPLLSFHQDNILCVYSHRQSVEINLQKVKANKTTTSVPLLPNNCPLDVSHAICSVGDNKVFVCGGVTTTTDVQTKDYTINPNAYLLDQKAGEWKTLAPPPEALDCPACCLAKLPCKILQRI
Protein: Probable sphingolipid long chain base-responsive protein pil2 (Protein kinase inhibitor pil2) (O14128)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity).
Interaction partners:
- Uncharacterized protein C63.14
- Zinc metalloprotease mde10
- Non-classical export protein 2 homolog
Sequence:
MGTQPSYSIHTLRAPPKAKQNQIPPSTTRRAVNVNKLGRQFRYPSVGMFTPEMAKRLAALVKMEKDLLRSYENVAMERKECANQLSYWGEDCDDDISDISDKLGVLLYEIGELEEHMVDRYDQYRVSLKTIRDIEASVQPTRVKKEKLLNSIYDVRSRDPESPKLITMEQELVREEAACLVAEAQLTNITRENFKRAFTLHIGTLLEHSEKVAILCGYAKKILDLLDDTPIVPGEPRPIYDGYNITRDYIVEAERELANWQNPFQTPEPLTDIDGLPSQSHYQTQFQASVVPRTDVINEPPRRYSHANGVTTSGTTHSYTSTGSKRYSQMGTEDYQPSFQPNILQSTQVVDNFEIGEEDDEEVGSQGVAETSMPSTSAQPIAA
Protein: Histone chaperone asf1 (Anti-silencing function protein 1) (Replication-coupling assembly factor subunit ASF1) (RCAF subunit ASF1) (dASF1) (Q9V464)
Organism: Drosophila melanogaster (Fruit fly)
Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Plays a role in the formation of silent heterochromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:12381660}. Chromosome {ECO:0000269|PubMed:11533245, ECO:0000269|PubMed:12381660, ECO:0000269|PubMed:16396992}. Note=Localizes to multiple sites on polytene chromosomes including transcriptionally active developmental puffs, the chromocenter and the histone gene cluster (PubMed:12381660). Localizes to active foci of DNA replication throughout S-phase and is lost from stalled replication forks (PubMed:16396992). Not detected on condensed chromatin during mitosis (PubMed:16396992). {ECO:0000269|PubMed:12381660, ECO:0000269|PubMed:16396992}.
Interaction partners:
- Chromatin assembly factor 1, p105 subunit
- Histone H3
- Protein HIRA homolog
- DNA replication licensing factor Mcm2
- non-specific serine/threonine protein kinase
- Nuclear autoantigenic sperm protein homolog
- Histone H4
- Histone H3.3A
- Histone acetyltransferase type B catalytic subunit
- Histone H2A.v
Sequence:
MAKVHITNVVVLDNPSSFFNPFQFELTFECIEELKEDLEWKMIYVGSAESEEHDQVLDTIYVGPVPEGRHIFVFQADPPDVSKIPEPDAVGVTIVLLTCSYRGQEFVRVGYYVNNDYADPEMRENPPTKPLFEKLTRNILASKPRVTRFKINWDYGHINGNGNGVENGHQDEMATDGPSTSEAASAVIHPEDDNSLAMPMENGIKALNENSNSLAMEC
Protein: MYB-like DNA-binding domain protein (O49019)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRAPCCEKVGLKKGRWTAEEDVLLTKYIQANGEGSWRSLPKNAGLLRCGKSCRLRWINYLRADLKRGNFTSQEEEVIINLHATLGNRWSLIASYLPGRTDNEIKNYWNSHLSRKIHSFRRPLTQSMPVIMDLTKTAVIAKRKGGRTSEGSMKENKSCSTQKDTGSCSNKPTENVCVNEVEPFPSTPLLEKETLSTTAIEDRMVLDQHGEDKERTTHVVPSPCHDTVVEGMLGSSEERESLVTEEGTIENSMQCPSGNAEKGTGILAPHESIDSSEIEWFNDILDSELLQPSGHLTFTELGEDRWNVKTHTTAANNEEIVSRNCSADSGGVLSSCTSTTFYFVDDWENVVPRSELWDEKEYMCSWLWEPSDYHGKGERHKVDDNGFEGHNPMIAANVAFLLMLLLVPPALVSSYTSMSIFYLGRQCEHVLPFFLFVLLLDFASLFNSDALFSL
Protein: Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH) (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase) (P51650)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- 4-aminobutyrate aminotransferase, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Citrate synthase, mitochondrial
- Malate dehydrogenase, mitochondrial
- ATP-citrate synthase
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Isocitrate dehydrogenase, mitochondrial
- Pyruvate carboxylase, mitochondrial
- Malate dehydrogenase, cytoplasmic
Sequence:
MATCFLLRNFCAARPALRPPGRLLREPAGAQRRSYVGGPADLHADLLRGDSFVGGRWLPTPATFPVYDPASGAKLGTVADCGVPEARAAVRAAYDAFSSWKEISVKERSSLLRKWYDLMIQNKDELAKIITAESGKPLKEAQGEILYSAFFLEWFSEEARRVYGDIIYTSAKDKRGLVLKQPVGVASIITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPYSALALAQLANQAGIPPGVYNVIPCSRTKAKEVGEVLCTDPLVSKISFTGSTATGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNAGQTCVCSNRFLVQRGIHDSFVTKFAEAMKKSLRVGNGFEEGTTQGPLINEKAVEKVEKHVNDAVAKGATVVTGGKRHQSGGNFFEPTLLSNVTRDMLCITEETFGPVAPVIKFDKEEEAVAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEVKYVCYGGL
Protein: Protein RecA (Recombinase A) (P65977)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
Interaction partners:
- LexA repressor
- DNA polymerase I
- Regulatory protein RecX
- DNA repair protein RecN
- Protein UmuD
- Fumarate hydratase class II
- DNA helicase II
- DNA gyrase subunit B
- ATP-dependent DNA helicase RecQ
- UvrABC system protein A
Sequence:
MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPVYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGDNVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYNGEKIGQGKANATTWLKENPATAKEIEKRVRELLLSNQNATPDFAVDDSEGVAETNEDF
Protein: Ly-6-related protein ODR-2 isoform 18 (Protein sleepless) (G5EEC7)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MAADVLQIVSYLLANVSDFNSALRLPCYSCMSPYLEDHYPYISHLYRKPLSFDTHCDKHSLETSYLYSKNCSDMCVTLRINDVVGGRRRHGYMRGCLSDLHGYNHSLIRTLAERQGCLDTTARELFLPTAQRQELEPSRLSLCACHNNLCNFSVSPPCFFIFLFVILVIFLMR
Protein: COP9 signalosome complex subunit 3 (H7C3P9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
Protein: Uncharacterized protein (C8VAX8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MSSAARYRPISPGSANMIDPLRASTGTVQLASSYDPYDPAGRPIYTGYRSDVPYSPTYDSRYPVAPRLEAHPVSQQTYHDPGQSTRLRTEYAIRPRQRSSTTSAADSHGRLGVPPISSVSRTSAVVLSDYGRSPSPLTDQDGYLVPASSRHHRHHRHSSYDYASDTGGQPTSRRHYGAYPTYVSRRRYPQNGGLRKGEDIDKYDAYSYTNPREQFEKEAVAKLQYHRNARKERPLSLTGIEDPRLLGRRDPRAHGPPPSHRGYDKVHRDDLRRSTYGFGNSELDLASARQRPPRSVTLHQDHDEGYSSYRDEFDDTRPAHREHKRPDGDARKRDTIDSHGARKPFNKQSPPSVSGSGLGTAVLASGYSEGQDYDLSSHADRYRHRGRVPRDRSRSRRRSRRRGGSESDECSSDDDLKKYRREPSVRPRINGSDSSKENEPHRHRSRSRHHERPSDKKSDQKKTDSKEPDAPPKGILKPPRDKFPEEPNPVREGVAPLKDAHKKGIPPGARWTKIDRRLVNPAALEAGQERFEERPDHVIVLRVLTKEEIQAYAVKTQEIRDSRYREYIRERRRQREEDRRRGRPVDDFSSDDEDESDNFPLAIEGPGEPRSSQKS
Protein: 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (EC 1.1.1.44) (Q94KU2)
Organism: Spinacia oleracea (Spinach)
Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MRSEVPSSTSPSFLSPPFIHLPLLSLSSPTPLPHSSSSTFSLFSTMAASQIGLVGLAVMGQNLALNIAEKGFPISVYNRTASKVDETLDRAKSEGDLPLSGHYTPRDFVLSIERPRSIVILVKAGSPVDQTIASLASFMEPGDTIIDGGNEWYQNTERRLSDAHSNGLLYLGMGVSGGEEGARFGPSLMPGGDFQAYDNIQHILKKVAAQVDDGPCVTYIGEGGSGNFVKMVHNGIEYGDMQLISEAYDVLKNVGGLSNEELGQIFDEWNKSELESFLVEITADIFKVKDDLADGGLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDCRYLSGLKEERENAAKILEAAGMKEEVNAIRGGVDKKRLIDDVRQALYASKICSYAQGMNLLRAKSAEMGWDLNLGELARIWKGGCIIRAVFLDSIKQAYQRNPNLASLVVDPEFAKEMVQRQAAWRRVVGLAVSAGISTPGMCASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDLPGSYHTEWSKLARKSDPNVAAALH
Protein: DNA (cytosine-5)-methyltransferase 1A (OsMET1a) (EC 2.1.1.37) (DNA methyltransferase 1-1) (OsMET1-1) (Q7Y1I7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probably methylates CpG residues and maintains DNA methylation. May be involved in methylation-dependent gene silencing. May play a minor role in the maintenance of DNA methylation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Adenosylhomocysteinase
- S-adenosylmethionine decarboxylase proenzyme
- DNA
- DNA
- DNA
- 1-aminocyclopropane-1-carboxylate synthase 2
- Os05g0149200 protein
- 1-aminocyclopropane-1-carboxylate synthase 1
- S-adenosylmethionine decarboxylase proenzyme
- Os05g0221800 protein
Sequence:
MAKSPRSVVTTGTKRRRAKVHKEDEPVENENLESEFDVSKKESNGATEPGNEPVASKRPKRAAACSNFKEKSLDLSEKDSIITIKESRVEEKEIEAVNLTRTGPEDGQPCRKIIDFILHDGDGNLQPFEMSEVDDIFITALIMPLDDDLEKDRGKGICCSGFGRIENWAISGYDEGAAVIWVSTETSDYKCVKPASSYRSYFEHFSEKARVCVEVYKKLARSVGGNPQVDLEELIAGVVRSINSNRSFNGTVTKDFVISSGEFIYKQLIGLDHTAGNDDEMLATLPVLVALKDECKSRAGFTHLPAMPSNGTLRIKDGQDKGLTEDEDAKLARLLQEEEEWKMMKQRGKRGTSQKNIYIKICETEIANDYPLPAYYKPYNQEMDEYIFDSDIGMYSDDVPVRILDNWALYNSDSRLISLELIPMKAGAENDIVVFGSGFMREDDGSCCSTAELAQLHSSSSKSGREDPGVPIYLSPIKEWVVEFGGSMICITIRTDVAWYKLRQPTKQYAPWCEPVLKTARLAVSIITLLKEQSRASKLSFAEVIKKVAEFDSRHPAFISSKAPTVERYVVVHGQIILQQFADFPDESVKRCAFITGLLAKMEESRHTKLAIKKKSQQMRGENLNPSAKMGPILRKKLMRATTTMLISKIWGEYYATYFPGDTKEEDQNEPKEIDDDQEENEDNDAEEEVNVQDEKATRTPPSTRSRKSSADTRKEIKWEGQTAGKTVSGEVLYKCVIVQDLSISVGATVTTEDDSGETIMCFVEYMYEKLDGKNMIHGIILQEGSQTVLGNAANDREVFLTNDCLEFEASDIKELVTVNIQSLPWGHKYRKENSEAKRIEKAKAEERKRKGLPVEYICKSLYWPEKGGFFSLPYDKIGNGTGICSSCERKPVGNEFKLLSESSFVFENITYNIHDFLYIRPEFFSQGEGHETYKAGRNVGLKPYAVCHLLSVHGPAGSRKANPESTKVKVRRFYRPDDISSTKAYSSDIREVYYSEDIISVPVVMIEGKCEVRLKDDLPNSDLPAVVEHVFCCEYLYDPANGALKQLPPNVRLVTLTRKVPASKKNKGKQICDIELGGSDKPKDGQSENCLATLDIFAGCGGLSEGLQRSGLSLTKWAIEYEEPAGDAFGENHPEAAVFVENCNVILKAIMDKCGDSDDCISTSEAAERAAKLSEDKIKNLPVPGEVEFINGGPPCQGFSGMNRFNQSPWSKVQCEMILAFLSFAEYFRPRFFLLENVRNFVSFNKGQTFRLTLASLLEMGYQVRFGILEAGAYGVAQSRKRAFIWAAAPGETLPEWPEPMHVFASPELKITLPDGKFYAAVKSTAAGAPFRSITVRDTIGDLPAVENGAGKPTIQYGSGPVSWFQKKIRSDMASLNDHISKEMNELNLIRCKHIPKRPGCDWHDLPDEKVKLSTGQMVDLIPWCLPNTAKRHNQWKGLYGRLDWEGNFPTSVTDPQPMGKVGMCFHPEQDRIITVRECARSQGFPDSYRFAGNIQNKHRQIGNAVPPPLAYALGRKLKQAIDAKR
Protein: Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) (P97865)
Organism: Mus musculus (Mouse)
Function: Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (By similarity). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:9090381}. Peroxisome matrix {ECO:0000250|UniProtKB:O00628}. Note=Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5. {ECO:0000250|UniProtKB:O00628}.
Interaction partners:
- Peroxisomal targeting signal 1 receptor
- PEX5-related protein
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX14
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 10
- 3-ketoacyl-CoA thiolase B, peroxisomal
- Peroxisomal ATPase PEX6
- Alkyldihydroxyacetonephosphate synthase, peroxisomal
- 3-ketoacyl-CoA thiolase A, peroxisomal
Sequence:
MSAARTLRVPGRHGYAAEFSPYLPGRLACAAAQHYGIAGCGTLLVLDQNESGLQIFRSFDWNDGLFDVTWSENNEHVLVTCSGDGSLQLWDTAKATGPLQVYKEHTQEVYSVDWSQTRGEQLVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSPHIPGCFASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKYNENLVVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDPLLETVEHHTEFTCGLDLSLQSPTQVADCSWDETIKIYDPVCLTVPG
Protein: PTI1-like tyrosine-protein kinase At3g15890 (EC 2.7.10.2) (Q9LSC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable disease resistance protein At5g45490
- Probable disease resistance protein At4g14610
- Probable disease resistance protein At5g66900
- Pentatricopeptide repeat-containing protein At3g18110, chloroplastic
- Probable disease resistance protein At4g27220
- Germin-like protein subfamily 1 member 13
- Disease resistance protein RPP13
Sequence:
MQLLNSCCGKGFDGKKKEKEEPSWRVFSLKELHAATNSFNYDNKLGEGRFGSVYWGQLWDGSQIAVKRLKEWSNREEIDFAVEVEILARIRHKNLLSVRGYCAEGQERLLVYEYMQNLSLVSHLHGQHSAECLLDWTKRMKIAISSAQAIAYLHDHATPHIVHGDVRASNVLLDSEFEARVTDFGYGKLMPDDDTGDGATKAKSNNGYISPECDASGKESETSDVYSFGILLMVLVSGKRPLERLNPTTTRCITEWVLPLVYERNFGEIVDKRLSEEHVAEKLKKVVLVGLMCAQTDPDKRPTMSEVVEMLVNESKEKISELEANPLFKNPYSSNENNREHVAEESSDVILEDKDHQQQQE
Protein: COMM domain containing 10 (H0Y9N4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
AESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKSLEKVLVEFSHKELFDFYNKLETIQAQLDSLT
Protein: Small ribosomal subunit protein eS8 (40S ribosomal protein S8) (Q5JR95)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK
Protein: ADP-ribosylation factor-related protein 1 (ARF-related protein 1) (Q8BXL7)
Organism: Mus musculus (Mouse)
Function: Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:17127620}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17127620}. Note=Located in the trans-Golgi in the GTP-bound active state. {ECO:0000269|PubMed:17127620}.
Interaction partners:
- Protein SYS1 homolog
- Conserved oligomeric Golgi complex subunit 8
- Guanine nucleotide exchange factor subunit RIC1
- Ras-related protein Rab-6A
- Vacuolar protein sorting-associated protein 52 homolog
- Golgin subfamily A member 1
- Conserved oligomeric Golgi complex subunit 6
- Ras-related protein Rab-6B
- Vacuolar protein sorting-associated protein 53 homolog
Sequence:
MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLSESKEAFEKVVSSEALDGVPILVLANKQDVETCLSIPDIKTAFSDCTCKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT
Protein: Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) (Q922R5)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity).
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.
Interaction partners:
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase 4 regulatory subunit 3A
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- CREB-regulated transcription coactivator 2
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Sequence:
MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPACELSKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDVLLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDNMLGSNTTNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDDDEEGKAVITPVEKSKTEDDFPDSYEKFMETKKAKESEDKENLPKRASSGGFKFTFSHSPSATNGTNSTNSKSVVSQTTPASSNVASSKTTSLATSVTATKGNLVGLVDYPDDEEEDEEEESSPRKRPRLGS
Protein: DnaA initiator-associating protein DiaA (P66817)
Organism: Escherichia coli (strain K12)
Function: Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
Interaction partners:
- D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
- Chromosomal replication initiator protein DnaA
- Outer membrane lipoprotein DolP
- Bifunctional protein HldE
- Penicillin-binding protein activator LpoA
- DnaA regulatory inactivator Hda
- UPF0102 protein YraN
- Histidine biosynthesis bifunctional protein HisB
- Lipopolysaccharide heptosyltransferase 3
- Lipopolysaccharide heptosyltransferase 2
Sequence:
MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD
Protein: L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) (Q9U518)
Organism: Dirofilaria immitis (Canine heartworm)
Interaction partners:
Sequence:
MQCEEAHVLVLYTGGTIGMKYIDGVYQPEANYLLHAIRDLSLLNDDDYVSTYYSDAEIRPYCLPPLQHSKKRVVYWMIEYDPLLDSSDMTFDDWIHIGKDIQRAYDQYVGFVILHGTDTLAYTACALSFMLENVRKPIVITGAQIPVCEVRSDGRENLIGALIIAANYDIPEVTVYFNNKLFRGNRTVKIDNRSMDAFESPNMLPIAYMDVDIKVNYDSIFRSPSMAPFVVHDQLCRNVGLLRIFPSMSIENVRASLQAPIEGVVLQTFGAGNMPSHRTDIIDELKKAVDRGCIIINCSQCVRGQVDIHYLTGKVLYDMGIIPGSDMTAEAALTKLSYVLSKDCWELVEKKAMMVKNIRGELTVAKAEPLKDLEIVSQMARFLHLSSSHEMKLLCHAIFPQLLCYAASNGDIEMLKALHENGVDLSVVDYNGRNALHVAASAGHVGAVKYLLTQGVSFHLRDQWDENALVSAVKMKNKILIETLRSAGALLSINSRRLGVELCLCASYGDTETLNSWLAAGADINQQDYNGETALHIAVKSRNKQLVHYLLDRDADPYKIDDFNLTPLRHAKKLNLQDLVIRMKKMKKVQ