wanglab/gogpt-training-data huggingface dataset:
Protein: B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) (Q67FY3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional regulator that may act as an activator (By similarity). Plays a role for mesoderm patterning in early embryogenesis.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- TROY
- Matrix metallopeptidase-21
Sequence:
MHSENKLSNHGKQVTSGAQSQLPNVNQAQQQAPAGIQGSKGSVSGNHGVKANQISPGNPGLKSLNQTGGGGGMMKTKAKRERSVSIDTGDQRESLTPVLEPDAKVEGVMRSKRRCVLERKQPYSGDEWCSGAETEEEDEKPLSATHREHVMCPSQGHSGSSTTGHVSDPGGPGLGSGHGPGIRTDLHSRPPQQVVYVFTTSLANSAAEAVMHGHTDSILLYHQQNVPRTKLDQSTGVGKVSNLAEHISSSHSPPIGTPKSQSGTPRPASVGGVGHLPGTSTPSSTGHPDSEPAQTHRGGGTSSNNGRSAVHTLGLGNSGPQSVGVSGTEGVDRPGAIPHHGAGVSPSTSPSVLSALRQSELGQRVGPGNTDGLSKEQLEHRERSLQTLRDIERLLLRSGTGVAQEDPRGPNGNPNGTNVNNNNSNDGGRGLEDGEIGGGIPGNCHINNAGMPGMPPVGGMKKYEEPLQSIISQTQNLGGPGLDDSLMGPHHGMPPHSHHLSSPSGLDMGPLLGPEGVTPEQLAWRKLQEEYYQEKRRQHDMNPHQHPQHFRIMPEMGMPGGPPMLMRGPPPPYHSKPGDQQWGPGPMVGGGMGGNARMMDMNQEGPRGPRFLGQMRGPSGGGGYPESPGGVLGVEGLGPQRPPRPGMGWLEEIPPNMGGGGPFHGCCPPGGPGGPPQHFQGDLDRPMTREEIYRRIHRLDLQQMSRQQQQAGLGGPRMMDNPGGPGFPNPGMAGGPPSRGDPMDFPVSRTIMGSPIGGVGGDGGPTMRDIVDSPLGGNLNMNMGMNINQQQQLLAQKLRGGPGVLGEMLNAEDISRIRASQNGRGGANKAMIPGPEGPLQFPNQSSFPGGQVDGPYLQQPGPDMYGPDQPGPPHLSSTSRLSHIPMNTGSRVTDLGARHPPDLPISVNPMGSPAIPPSHQLKSPSLSQEPSPLMPSPSAAGLKSPSQLPQSGPTHPPLPAASGAGTPSSTSIKSPQVMGPSLGLRSPSGSPGHLKSPSMPVASPGWTASPKAAMPSPGGPPSVKVTGNGGSSSTDTGMSLPPRSSNSTPISQPSNSINPSMPFTSSPDAPPSQNPLSLIMSQMSKYAMPSSTPLYHDAIKTIATSDDEMLPDRPLQPGTNMSVGGMGNHQSAQMLLSSQGAMGPHSGPQSPMGMVLQGGPPLSHDHPGPMLPSPNPMGIPGMPSEIMGGGGGPPDGIGPCNVSPMHTQNQMGGFPRIQGPLHSPIGGMGQQFPPRPDDVLPPQQMHLLSKGMSHQRPPHQPDSFPPMPMGDGPDLSEVIRPTHRGIPEFDLSRIIPADKPSSTLQYFPKSETMSQPQQNPHQGQPPPQVSSAQLLKQLSSSGPPHSNIPSSNPHIANLQNMMAEQQLPLHPSHCGMRPGMGMPQIGSRGMGSGGGMGPMCHPGHMMGRTGMSPQQQLQQQHHHQQQQAMMANNLLQHPSHPPRGMLSPQQHPHNLIAQQNLMMMQAKQRGMALPGEHFGQQGALMSPQGPMMGPPHSQTGMMGPQSLRQRSMSLDSPLGYGPGSMANMPF
Protein: Uncharacterized protein, isoform E (Q9VBL2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Potassium voltage-gated channel protein Shal
- Uncharacterized protein, isoform A
- Peripheral plasma membrane protein CASK
Sequence:
MASPPESPIEEVVYELEHTRVPKPIPVALEDLCRQTKFTKQEIRVMYRGFKTECPEGVVHEDCFKDIYAKFFPHGNSSLYAHYVFKAFDVNCNGAISFRDLLVTLSTLLRGSVYERLRWTFKLYDLNGDGRISRGELSEIILAIHELMGRRPHQPEDDRKARDQVDRVFRKLDLNQDGIITIEEFLEACLKDDLVTRSLQMFDNDLXXQEGELEPGLRNSRTIISLIDL
Protein: Proteinaceous RNase P 1, chloroplastic/mitochondrial (EC 3.1.26.5) (Pentatricopeptide repeat-containing protein At2g32230) (Q66GI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:20473316, ECO:0000305|PubMed:25732537}. Plastid, chloroplast {ECO:0000269|PubMed:20473316}.
Interaction partners:
- Ribonucleases P/MRP protein subunit POP1
- Protein GAMETOPHYTE DEFECTIVE 1
- Proteinaceous RNase P 3
- Proteinaceous RNase P 2
- Probable ribonuclease P/MRP protein subunit POP5
- Uncharacterized mitochondrial protein AtMg01280
- Pentatricopeptide repeat-containing protein At3g06430, chloroplastic
- Pentatricopeptide repeat-containing protein At5g04810, chloroplastic
- tRNA
- Pentatricopeptide repeat-containing protein At4g21170
Sequence:
MLRLTCFTPSFSRACCPLFAMMLKVPSVHLHHPRFSPFRFYHTSLLVKGTRDRRLILVERSRHLCTLPLAAAKQSAASPSENLSRKAKKKAIQQSPEALLKQKLDMCSKKGDVLEALRLYDEARRNGVQLSQYHYNVLLYVCSLAEAATESSPNPGLSRGFDIFKQMIVDKVVPNEATFTNGARLAVAKDDPEMAFDMVKQMKAFGIQPRLRSYGPALFGFCRKGDADKAYEVDAHMVESEVVPEEPELAALLKVSMDTKNADKVYKTLQRLRDLVRQVSKSTFDMIEEWFKSEVATKTGVKKWDVKKIRDAVVSGGGGWHGQGWLGTGKWNVKRTEMDENGVCKCCKEKLVCIDINPVETETFAASLTRLACEREVKANFNQFQEWLERHGPFDAVIDGANMGLVNQRSFSFFQLNNTVQRCQQISPSKRLPLVILHKSRVNGGPATYPKNRALLEKWKNAGALYATPPGSNDDWYWLYAAVSCKCLLVTNDEMRDHLFQLLGNSFFPRWKEKHQVRISVTREDGLKLNMPPPYSIVIQESEDGTWHVPMSVEDDLQTSRQWLCAKRSKTP
Protein: Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1) (A2AJN7)
Organism: Mus musculus (Mouse)
Function: Multifunctional transporter with an impact in cell morphology and differentiation. In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (By similarity). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis. In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance. Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species. In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor. In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8NBS3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8NBS3}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Collagen alpha-2
- Cytosolic carboxypeptidase 4
- Lipoxygenase homology domain-containing protein 1
Sequence:
MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAPMESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPQPPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGIIGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGHHYHTKRTSSLVSLLGIGRSPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP
Protein: phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (A0A8I6AH39)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MIATGWLPPCFDFYRLSWHRLRPWCRSPCRSIQTLRVLSGDLSQLPAGVRDFVERSAHLCQPAGIHICDGTEAENAATLALLEEQGLIRKLPKYENCWLARTDPKDVARVESKTVIVTSSQRDTVPLLAGGASGQLGNWMSPDEFQRAVDQRFPGCMQGRTMYVLPFSMGPLGSPLSRIGVQLTDSPYVVASMRIMTRLGTHVLQALGDGDFIKCLHSVGQPLTGHGDPVGRWPCNPEKTLIGHVPEQREIVSFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGQLRAINPENGFFGVAPGTSATTNPNAMATIQSNTVFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFSWRHGVFVGSAMRSESTAAAEHKGKTIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGARLPRIFHVNWFRRDEAGRFLWPGFGENARVLDWICRRLGGEDSARETPIGLVPKEGALDLSGLRAIDTSQLFSIPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALEERVQKM
Protein: SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) (Q9Z131)
Organism: Mus musculus (Mouse)
Function: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (By similarity). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O60239}; Peripheral membrane protein {ECO:0000250|UniProtKB:O60239}. Mitochondrion {ECO:0000250|UniProtKB:O60239}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000250|UniProtKB:O60239}.
Interaction partners:
- Tyrosine-protein kinase BTK
- Ras-related protein Rab-11A
- Ras-related protein Rab-11B
Sequence:
MDTALKRSRSDEPAELPPPAREVEEKEEEEERMEQGLEEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMIFIFYTFLQ
Protein: RNA polymerase I-specific transcription initiation factor RRN9 (P53437)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor RRN5
- RNA polymerase I-specific transcription initiation factor RRN10
- Upstream activation factor subunit UAF30
- RNA polymerase I-specific transcription initiation factor RRN7
- TATA-box-binding protein
- RNA polymerase I-specific transcription initiation factor RRN6
- RNA polymerase I-specific transcription initiation factor RRN11
- Histone H3
- Histone H4
- RNA polymerase I-specific transcription initiation factor RRN3
Sequence:
MSDLDEESQIETQIDAPIEDIIRGSELTTTTADKETLKSANELLDSLEHSHRVDLSLHLYSAYLLKRLLYKANEKKHFYEVNQFVKTQIKDNWTSWPNPNTIIDPSVDKLYEDIPEGIANVSVQPGEISNRALMHASDMMRVELDAQWQKFLSKSALDHDVTLDVDELNIPNEISRNILVKLDSLFEGLHDKIAKENEFDVRQDKHSNNIRANQIDDEPMQANRRIKYTYHDLVSRGCEMNEDMTDIYMKSLELYNDIPEKYKKRKFRLPKQILKKYHQPKKTSSYLKELLSKTREDFIPVEKLLKDKRLTSKDKSKLQRLNREETEDALNKRTFFQVKGYLEDENEISDYELDDCLIELPNGNI
Protein: Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b) (O95256)
Organism: Homo sapiens (Human)
Function: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Interleukin-18
- Interleukin-18 receptor 1
- Interleukin-37
- Immunoglobulin kappa variable 1-33
- Interleukin-18-binding protein
- Interleukin-32
- Granzyme A
- Interleukin-1 receptor accessory protein
- Granzyme B
Sequence:
MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
Protein: Sequence-specific DNA binding transcription factor (Q8GXR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription factor STKL1
- Transcription factor
- Probable transcription factor At3g04930
- B3 domain-containing protein At5g60142
- Protein indeterminate-domain 11
- V-type proton ATPase subunit c2
- V-type proton ATPase subunit H
- V-type proton ATPase subunit B2
Sequence:
MDTVNDSFSPGSSRPSPATLSREDCWSEEATFTLIQAWGNRYVDLSRGNLRQKHWQEVANAVNDRHYNTGRNVSAAKSQPYRTDVQCKNRIDTLKKKYKVEKARVSESNPGAYISPWPFFSALDDLLRESFPTSSNPDSTDNIPHQRLSLPMSINPVPVAPRSAIPRRPATSPAIIPHAGDDLLGFRGNLNAFAAAAAAAACPASEDDSEGSRSRSSGRSGSNKKRERKIEKKQGYKEVADAIERLGQIYERVEEKKRKEMVELEKQRMRFAKELECHRMQLFTEMQVRLHKLRRTSGSKGPTSSASAALDYGMMDFPSYF
Protein: Eukaryotic translation initiation factor-like (Q4QD60)
Organism: Leishmania major
Interaction partners:
- Putative eukaryotic translation initiation factor eIF-4E
- Probable eukaryotic initiation factor 4A
Sequence:
MDPNTCAPASAVTDEQPLTLLWGTWEMWCDMPQRQQGQSTENTNWLEQVKSIGLFDSAEGFWGIFNCTILPSQLPPNGSYYLFRKHIAPMWEHEANRRGGKWVIPFTGKASRSEGDLQPVDEAWQTLCLSAIGELFPGDEEEICGVTVSRGRQRTLPSGHATSALSEWKLCLWTRSADNRGSQIRIAEYIRKQLHLQPPSKEASRDGKSGEQDTLMEMPRSPDRSPVAKMREASGIPSAMTYVAHRDLMEAKQEFVKGGSSVAQAFRPKYTLAIDVRNEGV
Protein: Protein transport protein Sec61 subunit beta (P60467)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36261528}; Single-pass membrane protein {ECO:0000269|PubMed:36261528}.
Interaction partners:
- Protein transport protein Sec61 subunit gamma
- Protein transport protein Sec61 subunit alpha isoform 1
- 40S ribosomal protein S30
- Ubiquitin-like domain-containing protein.
- Ubiquitin-like domain-containing protein.
- Large ribosomal subunit protein eL19
- Translocon-associated protein subunit beta
- Signal sequence receptor subunit 4.
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Sequence:
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
Protein: Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog) (P56703)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Frizzled-8
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-7
- Protein Wnt-3a
- Tyrosine-protein kinase RYK
- Cerberus
- Wnt inhibitory factor 1
- Catenin beta-1
Sequence:
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
Protein: LD30155p (Lost) (Q9VN21)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Nucleolar protein 56
- Protein NipSnap
- HDC05827
- NHP2-like protein 1 homolog
- U3 small nucleolar RNA-associated protein 15 homolog
- Histone chaperone asf1
- Structural maintenance of chromosomes protein
- SUZ RNA-binding domain-containing
- RE54550p
- tRNA
Sequence:
MEDQSNAAPAVAAENGGNTAQEVSSTTQPIEPTKRSLRVQTWKKIQEGKVGIGFNNIFNRIPSFVGADKAAALFANEEEFKKAQHIKVNIDRVLHEFKELALLADKSVYLPSTRESSALCLKVDVLADATEEQKKEALRVQDIQKFRSEIGLDSGLKLDIVVIGSVVVSREGYRIGRGNGFADLDIGLLIELGAITPKTIIVTIVHDMQVVDSLPPNLFQKYDTPVDIIATPTEIIRVPKRLSFPNGVYWELLSERRLKILPVLQQLKEREEKAGKSISLKEEDTDVEQHQNNRRRRGPVRRRIQRGNPGRTTSQTDNEQPQGETAQKRTPRRKGRFVNRRRRTTKSEGDQSGVEAGAKTDDRKLPEAGTDERRSKKNKNSDFCIKLTNLSRDIRVKDLKSELRKRECTPMSISWKGHFGKCFLHFGNRKGVPSTQDDMDKVLKSLNDLSLTITTGGETAPAAAAGEGGEKAESAETATPVQTKTILVNVELIQFGEKKSASSTGANAGAGEDGKADAQNGGEAVTVAGGDVGGARIEAVDTTTV
Protein: Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) (Q64700)
Organism: Mus musculus (Mouse)
Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor E2F4
- Transcription factor E2F5
- Cyclin-dependent kinase 2
- Transcription factor E2F2
- Transcription factor Dp-1
- Transcription factor E2F3
- Transcription factor Dp-2
- Transcription factor E2F1
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 6
Sequence:
MASGGNQSPPPPPAAAASSEEEEEDGDAADRAQPAGSPSHQIQQRFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDCHPKDSKASSDPPCVIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLFEKKLLKGKEENLTGFLEPGNFGESFKAVNKAYEEYVLAAGNLDERVFLGEDAEEEVGTLSRCLSAASGTESAERTQMRDILQQHLDKSKALRVCTPLTGVRYVQENSPCVTPVSTAAHSLSRLHTMLSGLRNAPSEKLERILRSCSRDPTQAIADRLKEMYEIYSQHFQPDENFSNCAKEIANKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGVLEHDAFHRSLLACCLEVVAFSHKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVMPPQNLERTDEIYIAGSPLTPRRVGEVRADAGGLGRSITSPTTLYDRYSSPTVSTTRRRLFENDSPSEGSTSGRIPPQPLVNAVPVQNVPGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVAGSIQPLSAQALAGSLSSQQVTGTTLQVPGPVAIQQISPGGQQQNPGQPLTSSSIRPRKTSSLALFFRKVYYLAGVRLRDLCIKLDISDELRKKIWTCFEFSIIQCTELMMDRHLDQLLMCAIYVMAKVTKEDRSFQNIMRCYRTQPQARSQVYRSVLIKGKRRNSGSSESRSHQNSPTELNTDRASRDSSPVMRSNSTLPVPQPSSAPPTPTRLTGASSDVEEEERGDLIQFYNNIYRKQIQAFAMKYSQANAQTDTPPLSPYPFVRTGSPRRVQLSQSHPIYISPHNNEAMPSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLDDGSESPAKRICPENHSALLRRLQDVANDRGSQ
Protein: Truncated leptin receptor-3 (V9M5F1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKTMILSAMLTFLVHILIISHSAVLVEPVEVSPHGDLLDLPWQTELCCSSTPAQLHHGGEEEDTGSAPSDTGHPHTLQCLFRNFTSTLGPHPESELSRATCWDILCRVDETWDNVICDLKHPATSSDTSIPGSVALSLQHLTTLPDIEVNSTHGTDCVGEDSITCSVALHVVSSIVVVTANVSNTTAGPLVMLSVPPRTSQRLWKPSPPLNLTHTQTTEGELILSWSDPQPHASPVQLSYEVRYNTSQSTSHPNWLHVNVSGAQWVSLTGLGPGLQYTLQIRSHHPALPHLWSDWSQQHRIRLENVTYLPERVVASFGDSVTVYCVCNDLRVNASTMVWILNSRDRLPKSQYAAVNDRVSKITVRPSEQRLSGTLHCCQPFGEMYSCNYHYSTIYIKDPVIDISCVTSGDLDSMTCRWNNLPIGGINFMSRVADLSCDVMEEAERVGVPVGVVRQAKCESSGYRGVKSCNLQPIRVTSCYKLWMEAKTDNSTRSHPVYITPMDHVKPHPPSGLEAVSMPSGVLKLAWVPPELPIYDMQYQVRYALSTGKAHPFWQVLALQTESWAEVLEPDVCGVYNVQVRCMHINGSGTWSDWSHLLYTTTHNSRAPDQGPDFWRVFQEDPASMQTNVTLLFEHSPIVEPTYCVEELVVQHQDSGDTVTEERIGLVSSYSFEWRGEVHSVTVKAQNSQGSSTRNTHMTLDRHPKRQCVRSFSASRVNSSCVVLLWSLQPNSSVPWSLVVEWSGQNHQDRPDQTPESRERWTRFPPTDKLLYLYGHFYDTDEYEFILYPVFADGEGEPVYTKVFRGSDAGPAAYMLLMIIAFLSIVLFVTLVISQNQLMLLTWISGEGGGQRGNLSAQLKHFDFRGQLVQALN
Protein: Flt3-interacting zinc finger protein 1 (Q9WTJ4)
Organism: Mus musculus (Mouse)
Function: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10409713}. Nucleus {ECO:0000269|PubMed:10409713}.
Interaction partners:
Sequence:
MEDSSLPVVPAPIAAPGPAPSATAPRVPFHCSECGKSFRYRSDLRRHFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVCCNVGPCSVCGGGGSSGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRELAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSNAPPTQVWASGGGPEVAGEGDASEVGAAPQTWDAGLLLSPTGAGVPKLEALLPGDEGSGNDQAPAAAAEASSEDTLYQCDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGEGSGEAAPDGEGNQAAGGPGPGSSSRSKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD
Protein: At4g25030 (Serine/Threonine-kinase) (Q9SW23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDNCTGENPMASQLNILRCPFLRNINEPTNLSFSSSLPFPIPARAGKGPIFEDGPNFDTAFRLFHGQDGVVPLSDTARTEAQKPVPVFHPLAAKAATISLSSFGSGGPFGFDAFSDMFKNQKKKSDSSKNKGGNHEAMGDEWLKTGNCPIAKSYRAVSGVAPLVAKILQPPPGMKFKCPQAIVTARAAISKTPFAKNLRPQPLPAKVLVIGMLGMALNVPLGVWREHTEKFSASWFIALHAAVPFIGILRKSVLMPKTAMVFTIAASVLGQVIGSRAERRRLKSVAEKKLTLEVPNPSSVEADQMQFAGVSSDGRCGDKVVMKWNPMMLDVASPVSSGAATVVC
Protein: Tropomodulin (Tmod-like protein) (cTmd1) (Uncoordinated protein 94) (O01479)
Organism: Caenorhabditis elegans
Function: Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Tropomodulin
- Actin
- Alpha-actinin, sarcomeric
- Actin-depolymerizing factor 2, isoform c
- Tropomyosin isoforms a/b/d/f
- Profilin-3
- Actin-interacting protein 1
- Profilin-2
- Adducin-related protein 2
- Adducin-related protein 1
Sequence:
MSQAKTDYYSEEKTFSAPSANSQQGTQLPSKVYNKGLKDLEDNDIEGLLSSLSIDELEDLNNDFDPDNSMLPPSQRCRDQTDKEPTGPYKRDNLLKFLEDKAKTEKDWEDVCPYTPGQKRGKVYDSDSGRNSEEPENGKMEMPIEIDLDDDEEELECALVTAPEKDLVDLAGILGMHNVLNQPQYYNALKGKTQDESTGTTFNGIMQSYVPRIVPDEPDNDTDVESCINRLREDDTDLKEVNINNMKRVSKERIRSLIEAACNSKHIEKFSLANTAISDSEARGLIELIETSPSLRVLNVESNFLTPELLARLLRSTLVTQSIVEFKADNQRQSVLGNQVEMDMMMAIEENESLLRVGISFASMEARHRVSEALERNYERVRLRRLGKDPNV
Protein: Apoptosis regulator BAX-like (BCL2-associated X, apoptosis regulator a) (I3ITC2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- BCL2-like 11
- Apoptosis regulator Bcl-2
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Cytochrome c
- Uncharacterized protein LOC767645
- Apoptosis regulator BAX
- BH3-interacting domain death agonist
- BCL2-associated X, apoptosis regulator b.
- Diablo, IAP-binding mitochondrial protein a.
Sequence:
MEALLDYVVRIGSGNDQTLDAGSAVLFNFIFEWLHQHLDKEAEITCWLQNNLGIVEKSDPSHKDAIECMVRIANEMEGNEELQGMLNSALLNPTLEHYILVVNGTFSDVTLSWGSVVALFYVACRFVVKAAEINSVDLVRSIINWTMPFIRKTCILTWIREQGGWGAIRSYFGTPTWQTVGVFLAGVLTVGLVLYKM