wanglab/gogpt-training-data huggingface dataset:
Protein: Synaptotagmin-1 (Synaptotagmin I) (SytI) (A0A075F932)
Organism: Anser cygnoides (Swan goose)
Function: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes (By similarity). May play a role in regulating the secretion of hormones relevant to the reproduction and egg-laying of female geese.
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}. Note=Synaptic vesicles and chromaffin granules. {ECO:0000250|UniProtKB:P21707}.
Interaction partners:
Sequence:
MVSESHHEALAAPPATTVAAAPPSNVTEPASPGGGGGKEDAFSKLKEKFMNELNKIPLPPWALIAIAIVAVLLILTCCFCLCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQDDDAETGLTDGEEKEEPKEVEKLGKIQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEYKVAMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQIVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQPEEEVDAMLAVKK
Protein: cDNA FLJ43600 fis, clone SPLEN2002147, weakly similar to Halocynthia roretzi HrPET-3 (B3KWQ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVTLRSKLGPLEIQQFAMLLREYRLGLPIQDYCTGLLKLYGDRRKFLLLGMRPFIPDQDIGYFEGFLEGVGIREGGILTDSFGRIKRSMSSTSASAVRSYDGAAQRPEAQAFHRLLADITHDIEALAPDDDDDDEDEPRGSRGGSDAAEDNYL
Protein: Interleukin 1 receptor-like 1 (ST2L) (M1ZJW4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MTKRFFFSTSTLQVPVLQKMRSFTFRLVDGGLMFLLLSLTRISAQREMSLNPTTISHYTESPCQLFDKYETTVTEGEALSLPAYYDLSELVWASVTEFTWYRNRTQELSSSEEERVHHHGPVLFFLPLLINDSDQYYTYWRKGADTCLIFVTEVIVVKAQPFDHSVLFNDISESAENIAIPCPDPVEKLCQDGKDNLAWYKNFSLIPNESERNLWVYGASKADEGIYTCVCTWEHNGTVLNTSASRRLKIQAPSASHPPQINLPINGSTETTDLYTTKKLRCEAFCGQNIEDNCHVWWEINGVKVRSQQQGYSVNTTSEVEVSSMRSIFTAILTINTVTMRDLQSKFTCVAMNDQKWNYAVVTLKLRGFMGLCVVLLLFFLLAAVAVKVFDIDLALLFRGVFKCCGRSEDGKVYDAYVVYQMDGLDQEREEKVYHFVSIVLPTVLEQKCGFRLFIHGRDDLPGEDNMELVEACMRLSRRLIVILTPSSSTRSGSGGQGSCGQWGYSSSLTTAEDYDCQVGLLQALVHSEMNVILIQLGDMGEGGYTHLPPGLQHLVRKSAPLMWHEGRRGSTLPNSSFWKRVRYMMPWPRSTSFDNQLI
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (F4KB75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSSAQTPLFLANQTKVFDHLIPLHKPFISSPNPVSQSFPMWRNIAKQAISRSAARLNVSSQTRGLLVSSPESIFSKNLSFRFPVLGSPCHGKGFRCLSGITRREEFSKSERCLSGTLARGYTSVAEEEVLSTDVEEEPEVDELLKEMKKEKKRESHRSWRMKKQDQFGMGRTKFQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPNLPYVKSLFLGWFEPLRDAIAKDQELYRLGKSKATYAHYLDQLPADKISVITMHKLMGHLMTGGDNGCVKVVHAACTVGDAIEQEIRICTFLDKKKKGDDNEESGGVENETSMKEQDKLRKKVNELIKKQKLSAVRKILQSHDYTKPWIADVRAKVGSRLIELLVRTAYIQSPADQQDNDLPDVRPAFVHTFKVAKGSMNSGRKYGVIECDPLVRKGLEKSGRYAVMPYMPMLVPPLKWSGYDKGAYLFLTSYIMKTHGAKQQREALKSAPKGQLQPVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGCVADMVDRSDVPLPEKPDTEDEGILKKWKWEVKSAKKVNSERHSQRCDTELKLSVARKMKDEEAFYYPHNMDFRGRAYPMPPHLNHLGSDLCRGVLEFAEGRPMGISGLRWLKIHLANLYAGGVDKLSLDGRLAFTENHLDDIFDSADRPLEGSRWWLQAEDPFQCLAVCISLTEALRSPSPETVLSHIPIHQDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADRDPEVFPEALRARKLLNQVDRKLVKQTVMTSVYGVTYIGARDQIKRRLKERSDFGDEKEVFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIASENETVRWTTPLGLPVVQPYHQMGTKLVKTSLQTLSLQHETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVACKRAGVCFAGVHDSFWTHACDVDKLNIILREKFVELYSQPILENLLESFEQSFPHLDFPPLPERGDLDLKVNIVSTPRLELYVLDGREERQTSCKGQNKRKAAGFCIQRRRQREGVEEIL
Protein: mRNA export factor elf1 (O14134)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a direct role in the mRNA export process. Appears to act within the rae1 mediated mRNA export pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12110682}. Nucleus {ECO:0000269|PubMed:12110682}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 4
- U3 small nucleolar RNA-associated protein 21 homolog
- H/ACA ribonucleoprotein complex subunit nhp2
- Large ribosomal subunit protein eL27B
- Elongation factor 3
- Elongation factor 1-gamma
- Large ribosomal subunit protein uL30C
- U3 small nucleolar ribonucleoprotein protein imp3
- Large ribosomal subunit protein uL30A
- Large ribosomal subunit protein uL30B
Sequence:
MTSSVLIQGYEEDDVLKLLQELLDAETSQSCADVGKKIAQLFSNDNPLVTLKTTGFLDGLERAARNKKSGFHREAAMIGFATVIKNLGTPSEVVFLPYLPTILDSFSDRGEVVRQAAKMAAQALLDCLPAGAVETRLIPSLISYLDDSSIKWPSKVAALQLLGSLASSSPKAVADYMAALIPCIKERMHDTKPEISRAAITCMLNLCSVVENNDIIPHIPKLVDCMAHPETLEACIKDLSATTFVATVESVALAVLVPILKRALAQRSQSMLRLTVIITDNLCKLVPDPAEASDFLPELIPDVERIAQTAAMPEVRALASHALTTLNKAAAAQAAKAANNSEKQALDSACKELREAVLKNTSVPHELANSIIDYVCDALAALYKSNNFDKDKWTSQLGVLYLSPLVGEELASQISSKIYDDLHAFYKSLNSVDGISNLTIEEEELVNTDFSLAYGGRLLLSHTNLHLYRGHRYGVVGHNGCGKSTLLRAIGDYKVENFPSPDEVKTCFVAHSLQGEDTSMAILDFVAQDKALLTMNVTRQEAADALHSVGFTAEMQENPVASLSGGWKMKLELARAMLQKADILLLDEPTNHLDVANIAWLEAYLTSQKNITCLIVSHDSSFLDHVCTDIIHYEGVKNQAKKLGYYQGNLSAFVKVKPEAKSYYTLTATNEKFVFPPPGILTGVRSNTRLILKMTNASYTYPNAKKKSLDNVTVGLSLSSRVAILGPNGAGKSTLIKVLIGEVIPQEGKVFKHPNLRVGYVAQHAFHHLDQHLEKTPSQYIQWRYAGGQDREVSEKESRKLTEEDRAQLQRDITVNGERRRVEALIGRQKLKKSFQYEIKWFGKPHKYNTWVSREILLENGFQKFVQAFDDMESSREGLGFRELIPEDIRAHFEDVGLPGDIADYSPISSLSGGQKVKVVIAACLWNNPQLLVLDEPTNFLDRDALGGLAVAIRDWEGGVVMISHNEEFVSALCPEHWHVEAGKVTGKGKTAVDDGKFEDLSEKDLKKIEAKATKKKKLTRNEIKAKERRARERELAWLQSPKGTEKPKSFFSDDEE
Protein: Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326) (P16422)
Organism: Homo sapiens (Human)
Function: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Subcellular location: Lateral cell membrane {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:16054130, ECO:0000269|PubMed:19785009}; Single-pass type I membrane protein {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}.
Interaction partners:
- Claudin-7
- CD44 antigen
- CD9 antigen
- Receptor tyrosine-protein kinase erbB-2
- Epidermal growth factor receptor
- Mucin-1
- DNA mismatch repair protein Msh2
- Signal transducer CD24
- Cadherin-1
- Immunoglobulin kappa variable 2D-29
Sequence:
MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA
Protein: Hydralysin-2 (Q564A5)
Organism: Hydra viridissima (Green hydra) (Chlorohydra viridissima)
Function: Induces an immediate fast muscle contraction followed by flaccid paralysis when injected into blowfly larvae. Has strong cytolytic activity against insect Sf9 cells and human HeLa cells, weak activity against human JAR cells, and no activity against human HEK293 cells. Binds to erythrocyte membranes and has hemolytic activity, probably mediated by oligomerization and pore formation.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q86LR2}.
Interaction partners:
Sequence:
MGKELLTFSDLTWLDSSPDTVRSAFTRQYGTTPDGIALNSEGYFGYHSPPITEQYGRPCYKQTGETKITLQDLAPPTDAILGNSIARNRGDSPITLTVSVEGKWSDSTSWSTSTETGVKMSSEFGVEGAFKMGGEFSLTVSVGKSGSSSVEKTSTSSVQVTVPPRSKVVVSMVGIMKKEKVFFEVPVTVDGSFGANFPSTVQGHYFWFMDARSCLNKTSGVIKGTIDHANVFDVSVEVGPSEPL
Protein: MAP kinase phosphatase with leucine-rich repeats protein 1 (EC 3.1.3.16) (EC 3.1.3.48) (Q55CS7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development.
Interaction partners:
Sequence:
MIFKKLFSKGSTSPTTRPRGATFSGTFPTDVLSDDGSGTNTNGLSNSTTNPSSIHSTPTTPTTTASTNLTNSNKLSTLAPITNGNRSLRGSKDGSGTTKESKKKVLTLNEKQKLLLKSMEYIKGSGTYYGNYMEFYEIPIQIYVGTEPSETYPSLSYNTELRSLILDFNKITEIPEQIGLLPNLKHLSLAANQLSQVPEFLSQLKSLESLELGINQFTSFPLNICKIKSLTLLRLETNNIKSLPDDFINLENLKDLSLLDNQLKEIPDSLPNNIEKLNLGCNDIINSYSKSLIRISHSLTTLNLSENKIEVLDESLSCLVNVKTLILDCNMIKVIPGSVLGSWKSLVTLNLPHNFISDLPAEIVTLDNLRIIDLRGNNFEFCKNYPSSESSSILFKIEEFIKDKEKLKSLILKENLEILSKLKDDNSTTTTTNINSNLDVPIIITTNIETIPTTSTTATTTETTNDITFKISDITEIIEKTDTTTTTTTTNQTDNVKLEEKVYEKQENDENNSVTLETTTTISIASDNTDEASIQIPQKEDGDKENLENDDKLLQESFSENNNNNNNEKQQEQQENPLKESQGKIQQLEEELEKLEQKQLELKDKIRLEKIKYQEIQQQSPRLSQQENNQEAIVVNTQPSSPPPTIIVNEQKSEKLENEKPTKREQPMVVVTKNNNKAEVEMTAPNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGGVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLSK
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CT5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MRRSMYWVVFLVAALQGIHLVSGQDIVNQKEFEALCRIVNWAEKGLKQITLARQVTQEAQKIGVRYLEVVGEENAAELAKTQEDSCAYKREVGGRNCVLYKTFWQHAQEALKGTARSSVHHRAMNTLEYHTIEKIKEKAMHGADIYHDVGAESLSVKVEKIERKINQALYGMEYFTEEIKPGGDRSRVCGQSSRSEMIIGGNSLAVDFLCLCAMHSSWNGIKVCCTDCTTGENSNEWDPESNGVQRWKFLKQKCADHNPNYYDTEKRLRNAKQNFMDTVTTIHGRGGRTLYKLGKKQSSEVNNCGAGTGRGQGICVLYKGHGEELPWMKALVEVENEMEVLLQDKHNKSAKLERIKELSQEIEKLIKGDPGRGGQRGRQKRSVNPENSVPETPADPSDPTQSVPHTNEKKRSVRKPISTGNGATKSYNSEEDDSYEYECEGENSACSDSPAKPTVKNSKSAINCPLGLILLLV
Protein: Eukaryotic translation initiation factor 3 subunit L (eIF3l) (F4JY76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03011}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit A
Sequence:
MASSNEYEEGPGERESGYDPNMVPDSVKSFVSHMYRHIRDKNVYEIHQMCETSFQSISERLFKDTPWPSVEAIAPYVDNDHVFCLLYREMWFRHLYARLSPTLKQRIDSYDNYCSLFQVVLHGVVNMQLPNQWLWDMVDEFVYQFQSFCQFRAKLKNKTEEEIALLRQHDKAWNVYGVLNFLQALVEKSCIIQILEHDKDGLEFTETDGYDFSGGSNVLKVLGYFSMVGLLRVHCLLGDYHTALKWLQPIDITQPGVYTSVIGCHIATIYHYGFATLMLRRYVDAVREFNKILLYIFKTKQYHQKSPQYEQLLKKNEQMYALLALSLSLCPQTKLVDESVNSQLRDKYGEKMMRMLRSDDEAFGIYDELFSYACPKFITPSAPPTFEEPLVNYNQDAYRLQLKMFLYEVKQQQLLSGVRTFLKVYSSISLAKLANYMEVDEPTLRTILLTYKHKTHSVDSDGRIISNADIDFFINNDMIYVVESKPAKRYGDFFLRQIAKLEGVINDMDRVKLE
Protein: Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein] (P18173)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for cuticular modification during development.
Subcellular location: Secreted. Note=Secreted as part of the seminal fluid transferred to females.
Interaction partners:
- Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein
- Enolase
- Phosphoglucomutase 1
- Multiple inositol polyphosphate phosphatase 1
- L-lactate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Glucose-6-phosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- Hexokinase type 2
- Phosphotransferase
Sequence:
MSASASACDCLVGVPTGPTLASTCGGSAFMLFMGLLEVFIRSQCDLEDPCGRASSRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSMFLNFIGSDIDYRYNTEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKSEDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVEVSDQFGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFFIDDADTAPLNWATAMEYLLFRDGLMSGTGISDVTAKLATRYADSPERPDLQLYFGGYLASCARTGQVGELLSNNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAWGAKVURVDATWTLHRVI
Protein: Stanniocalcin-2 (STC-2) (Q9R0K8)
Organism: Rattus norvegicus (Rat)
Function: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Pappalysin-1
Sequence:
MCAERLGQFVTLALVFATLDPARGTDSTNPPEGPQDRGSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIQGLHGICMTFLHNAGKFDAQGKSFIKDALRCKAHALRHKFGCISRKCPAIREMVYQLQRECYLKHDLCSAAQENVVVIVEMIHFKDLLLHEPYVDLVNLLLTCGEDVREAVTRSVQAQCEQSWGGLCSILSFCTSNIQRPPTAAPEHQPLADRAQLSRPYHRDTDHHLTANRGAKGERGSKSHLHAHARGGAGGQSAQGPSGSSEWEDEQSEYSDIRR
Protein: ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) (Q96TA2)
Organism: Homo sapiens (Human)
Function: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10843804, ECO:0000269|PubMed:22262461}. Mitochondrion {ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975}.
Interaction partners:
- Complex I assembly factor TIMMDC1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- ATP-dependent clpX-like chaperone, mitochondrial
- Presenilin-associated rhomboid-like protein, mitochondrial
- Metalloendopeptidase OMA1, mitochondrial
- Presenilin-associated rhomboid-like protein, mitochondrial
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- Stomatin-like protein 2, mitochondrial
- Prohibitin-2
- Lon protease homolog, mitochondrial
Sequence:
MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR
Protein: Protein svp26 (Q1MTR8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in retention of a subset of membrane proteins in the early Golgi compartments.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Early Golgi. {ECO:0000250}.
Interaction partners:
- Translationally-controlled tumor protein homolog
Sequence:
MIVLNALSYLGIVLGFIGMTVSIASALYYISEFVEEHSRLAKAFLCRLVYFIMAVMVFLVIFDGFPFWLSAFSIFSHYIYKINFDTFPFFSFKRMRFLLACFLIVANHILWVRFFQVHEFPIKPRGLTYDFVGQRLLTSRASFSQVASFMGVCVWSVPIGIFVSFTAADNTLPTITTPSSSSPDAYSSGSSRRTSNVLRQAYKKLGIFVERSLTSLGLSDRSSERYV
Protein: Protein LITTLE ZIPPER 3 (Q9LXI8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Competitive inhibitor of the HD-ZIPIII transcription factors in shoot apical meristem (SAM) development. Acts by forming non-functional heterodimers. Part of a negative feedback loop. Involved in SAM development and lateral organ patterning. Essential for proper functioning of stem cells in the SAM.
Subcellular location: Nucleus {ECO:0000269|PubMed:18408069}.
Interaction partners:
- Protein LITTLE ZIPPER 1
- Protein LITTLE ZIPPER 2
- Homeobox-leucine zipper protein ATHB-15
- Homeobox-leucine zipper protein ATHB-14
- NADH dehydrogenase iron-sulfur protein 5-B
- At5g65925
- Homeobox-leucine zipper protein ATHB-9
- Homeobox-leucine zipper protein HAT3
- Homeobox-leucine zipper protein REVOLUTA
- Peter Pan-like protein
Sequence:
MERLNSKLFVENCYIMKENERLRKKAELLNQENQQLLFQLKQKLSKTKNSNNGSNNDNKSSSASGQS
Protein: Protein Churchill (Q8WUH1)
Organism: Homo sapiens (Human)
Function: Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity).
Interaction partners:
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein farnesyltransferase subunit beta
- Zinc finger E-box-binding homeobox 2
- Actin-related protein 2
Sequence:
MCGDCVEKEYPNRGNTCLENGSFLLNFTGCAVCSKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF
Protein: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BTB/POZ domain-containing protein KCTD13) (A9ULR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WZ19}.
Interaction partners:
- Double C2-like domain-containing protein alpha isoform X2
- Kinesin-like protein KIF22
- Seizure-related 6 homolog
- Aspartate beta-hydroxylase domain-containing protein 2
- UBX domain protein 7.
- Cullin 3
- Cullin-3A
- TLC domain-containing 3Ba.
- Proline-rich transmembrane protein 2
- Protein yippee-like 3
Sequence:
MSAEASGSSGGHAVTVSGSSPSSSSHVGEEKPGRSLVSSKYVKLNVGGTLHYTTVQTLSKEDSLLRSICDGSTEVSIDSEGWVVLDRCGRHFSLVLNFLRDGTVPLPDSTRELEEVLKEAQYYRLQGLVQHCLSTLQKRRDVCRGCHIPMITSAKEEQRMIATCRKPVVKLQNNRGNNKYSYTSNSDDNLLKNIELFDKLGLRFNGRVLFIKDVLGDEICCWSFYGEGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENGRGSGGMALLESGGVSSSGAGQSEEEGAGAGGGDRRVRRIHVRRHIMHDERGHGQQTVYKD
Protein: FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Structure-specific recognition protein) (Q54G78)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- FACT complex subunit SPT16
- Plus3 domain-containing protein
- RNA polymerase II complex component
- Transcription initiation factor Spt4
- FACT complex subunit
- RNA polymerase II complex component
- RNA polymerase-associated protein LEO1
- RNA polymerase II-associated factor 1
- Transcription elongation factor SPT5
- Transcription elongation factor spt6
Sequence:
MSSSSNPVSQFNNISLGGRISGTRGILKFTTNNITWKSENGKIETVSSSDIKRANWARVTPRIFQLILSIKGGATVKFDGFKEQDYEVVRKYLSDQYNVSPLEIIELSSKGCNWGEVKVNGPMIQFTTDHGKVGFEFPISEVSQSVIGANNKNELTLEFHHDKAMDDDDETMVEMRFFTPIRPSKEGEEGGKEKKVGEDGEEDEEDEEDAEKEEEISALEQFQQTIMNKSDMVSNVGKSLVVFSAIQFLTPRGRIDIEMYPTFLKLHGKTHDYKVPYESISRLFQFFRPDQKHIFFIISLDPPIRQGQTKYAHLVIQFQAEENIHLELNLTDELQQKFKDQLSPIMNGNANALICKILKALTGKKITIPGNFQSDSGANSIKCSLKANEGYLYPLERCFFFVHKPPTYIKFEDISNIEFARYGAPSVRGGSNRTFDLSINLKNSTSIQFVNIQREEYPSLFNFLKEKKLSILNPVTTGPAMIIDDDDSDDDDYEPSESGSESDEGSASDESEEESEEDKKAKKKQKK
Protein: Cysteine-rich receptor-like protein kinase 11 (Cysteine-rich RLK11) (EC 2.7.11.-) (Receptor-like protein kinase 3) (Q9ZP16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Kinesin-like protein KIN-6
Sequence:
MKQRSLFSVLCFFFISFGVASVSAQTCTTDKGTFRPNGTYDVNRRLILSSLPSNVTDQDGLYYNGSIGQQPNRVYAIGMCIPGSTSEDCSDCIKKESEFFLKNCPNQTEAYSWPGEPTLCYVRYSNTSFSGSADLNPRNWLTNTGDLDSNLTEFTKIWEGLMGRMISAASTAKSTPSSSDNHYSADSAVLTPLLNIYALMQCTPDLSSGDCENCLRQSAIDYQSCCSQKRGGVVMRPSCFLRWDLYTYSNAFDNLTVASPPPEPPVTVPQPAGDQDNPTNNDSKGISAGVVVAITVPTVIAILILLVLGFVLFRRRKSYQRTKTESESDISTTDSLVYDFKTIEAATNKFSTSNKLGEGGFGAVYKGKLSNGTDVAVKRLSKKSGQGTREFRNEAVLVTKLQHRNLVRLLGFCLEREEQILIYEFVHNKSLDYFLFDPEKQSQLDWTRRYKIIGGIARGILYLHQDSRLKIIHRDLKASNILLDADMNPKIADFGLATIFGVEQTQGNTNRIAGTYAYMSPEYAMHGQYSMKSDIYSFGVLVLEIISGKKNSGVYQMDETSTAGNLVTYASRLWRNKSPLELVDPTFGRNYQSNEVTRCIHIALLCVQENPEDRPMLSTIILMLTSNTITLPVPRLPGFFPRSRQLKLVSEGSESDQYTSKSSSFSS
Protein: Histone H4 (P62801)
Organism: Gallus gallus (Chicken)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H3.3
- Histone H3.2
- Histone H3
- Histone H3
- Histone-binding protein RBBP7
- Histone acetyltransferase type B catalytic subunit
- Histone H2A-IV
- DNA
- MSL complex subunit 3
- Histone-binding protein RBBP4
Sequence:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG