wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase BRE1A (BRE1-A) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) (Q5DTM8)
Organism: Mus musculus (Mouse)
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5VTR2}.
Interaction partners:
- E3 ubiquitin-protein ligase BRE1B
- Ubiquitin-conjugating enzyme E2 A
- Ubiquitin-conjugating enzyme E2 B
- RNA polymerase-associated protein CTR9 homolog
- WW domain-containing adapter protein with coiled-coil
- Histone H2B type 1-B
- RNA polymerase-associated protein LEO1
- Histone H2B type 2-B
- Histone H2B type 1-P
- Histone H2B type 1-C/E/G
Sequence:
MSGIGNKRAAGEPGTSMPPEKKTAVEDSGTTVETIKLGGVSSTEELDIRTLQSKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGDGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLSRKLNSGDNLIVEEAVQELNSFLAQENVRLQELTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRHCELEKLRQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPTELKQDSEDLATHSSALKASQEDEVKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSVKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDLFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYIG
Protein: A kinase anchor protein 6 (Akap6 protein) (Q6PGB9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Interaction partners:
Sequence:
MLTMSVTLSPLRSQDPDPMATDASPMAINMTPTVEQEEGEGEEAVKDVGAEQQYGKPPPLHTAADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDADSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETTEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTTSQAKTKSFDSWSYSEMEKEFPELIRSVGLLTVATEPVPSSCGAANEDSSQVILSEDHRGGHEEDGALEPGEQLGSTLETSSLGDTLTNAAEHPPETANQDSTSSPQLGAKKSQPGPCEMMTPKRSIRDCFNYNEDSPTQPTLPKRGLFLKETLKNERRGSDGKGRVVDLKPELSRSTPSLVEPPDRSKLCLVLQSSYPSSPSAASQSYECLHKVGIGNLENIVRSHIKEISSSLGRLTDCHKEKPRLKKPHKTLAEVSLCKIPKRGTGSGKQSENTRSSVVPTMVSPGAPKATARPATDSASTTSGDTCHQRNRGGKLPAQSKASSSSPCSHSSESSLGSDNIKSPLPLLSKSQKGSPPAPCHATQNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETIQDIDDWELSEMNSDSEIYPTYHIKKKHTRLGTVSPSSSSDIASSLGESIESGPLSDILSDEDLCMPLSGMKKFTDEKSERPSSSEKNESHSATKSALIQKLMKDIQHQDNYEAIWERIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLRLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLKMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEAQLCYLEAQRDAVEQMSLKLYSEQYTSGSKRKEEFADMSKAHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGLSLPNDILEKVDSINEKWELLGKTLREKIQDTMAGHSGSGPRDLLSPESGSLVRQLEVRIKELKRWLRDTELFIFNSCLRQEKEGTSAEKQLQYFKSLCHEIKQRRRGVASILRLCQHLLDDRDTCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLRKKMGKESIAWLKLGAGLTHPGLVLGSILLSSLPPATLTS
Protein: Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease 3) (rMCP-3) (Mast cell protease 5) (rMCP-5) (Mast cell protease III) (rMCP-III) (P50339)
Organism: Rattus norvegicus (Rat)
Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Subcellular location: Secreted. Cytoplasmic granule. Note=Secretory granules.
Interaction partners:
- Mast cell protease 1
- Mast cell carboxypeptidase A
- Tryptase beta-2
- Angiotensinogen
- Kit ligand
- Angiotensin-converting enzyme
- Angiotensin-converting enzyme
- Tyrosine-protein kinase Fyn
- High affinity immunoglobulin epsilon receptor subunit alpha
- Renin
Sequence:
MNLHALCLLLLLLGSSTKAGEIIGGTECIPHSRPYMAYLEIVTSDNYLSACSGFLIRRNFVLTAAHCAGRSITVLLGAHNKTYKEDTWQKLEVEKQFIHPNYDKRLVLHDIMLLKLKEKAKLTLGVGTLPLSANFNFIPPGRMCRAVGWGRTNVNEPASDTLQEVKMRLQEPQSCKHFTSFQHKSQLCVGNPKKMQNVYKGDSGGPLLCAGIAQGIASYVHPNAKPPAVFTRISHYRPWINKILREN
Protein: General secretion pathway protein F (E0SM39)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU003923}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU003923}.
Interaction partners:
- Type II secretion system protein E
- Type II secretion system core protein G
- Secretin OutD
- Type II secretion system protein L
- Type II secretion system protein C
- Conserved protein with nucleoside triphosphate hydrolase domain
- Type II secretion system protein E
- Prepilin leader peptidase/N-methyltransferase
- Type II secretion system protein H
- Type II secretion system protein J
Sequence:
MALFQYQALNAQGKKSQGMQEADSARHARQLLREKGLVPVKIEEQRGEVTTRSGFSLSLRRSHRISASDLALLTRQLATLVAAALPLEEALDAVAKQSEKPKLSALMAAVRAKVVEGHSLAEAMGNFPGSFERLYCAMVAAGEASGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLTLVAISVVSILLSAVVPKVVEQFIHMKQALPLSTRLLMGVSDAVRAYGPWVVLLLVLAVMGFRVLLRQEKHRLVFHRRLLFLPLIGRIARGLNTARYARTLSILNSSAVPLLQAMRISGDVLTNDYARFRLGQATDAVREGVSLHKALEQTSLFPPMMRHMIASGERSGELDGMLTRAADNQDREFSAQMTLALGLFEPLLVVSMAGIVLFIVLAILQPILQLNTLMSM
Protein: Golgi SNAP receptor complex member 1 (Q2U2P3)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
- Uncharacterized protein
- t-SNARE coiled-coil homology domain-containing protein
- Protein transport protein BOS1
- Protein transport protein SEC22
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Synaptobrevin homolog YKT6
- Sequence orphan
- Soluble NSF attachment protein
Sequence:
MAASTGTGWAQLRQQARSLETQTESLFHSYSQYASMTKLPPDPSEEEIRLESQLKELLEKRQSLVSQLARLLDSEATLTSSALKQNNLARHREVLQDHRRELQRLTSAIAESRDRANLLTNVRSDIDAYRASNPAAAEADYMLEERGRIDQSHNVIDGVLSQAYAINENFGLQRETLASINRRIVGAASQVPGMNALIGKIGSKRRRDALILGAFIGFCFLMLLFFR
Protein: Alpha-actinin, sarcomeric (Q23158)
Organism: Caenorhabditis elegans
Interaction partners:
- Vinculin
- Actin
- FERM domain-containing protein
- Paralyzed arrest at two-fold protein 6
- Paxillin homolog 1
- Zyxin
- Twitchin
- Tropomyosin isoforms a/b/d/f
- Troponin T
- Troponin T
Sequence:
MVDYYQQPPSYHQPGYDYTQQEEEWDREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDTIEEDFRNGLKLMLLLEVISGEPLPKPDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVKMTLGLIWTIILRFAIQDINVEELSARDGLLLWCQRKTAPYNNVNVQNFHNSWKDGLAFCALIHRHRPDLLDYSQLHKGDPIHNLNLAFDIAEKHLDIPKMLDAEDVSRHPDEKSTMTYVSCFYHAFRNMRDPPPPVIRQPPPQRVVVAPPPERDWRKDAETAANRICRVLKVNQENEKMMEDYENLASDLLAWINRWMPWLANRSTDDTLQQAQQKLEDYRNYRRREKPPRIEDKGRLETLFNTLQTRLRLSNRPAFLPRDGHLIKDINAAWAGLEDSEKGFEEWLLSEIMRLERLEHLAEKFRRKCALHEEWAHGKEDALRSNDWRSCGLYKIKALRKRHEAFESDLGAHQDRVEQIAAIARELNNLRYPDIGPINARCQAICSQWDRLGQLSSKRRETLEDAERIAERLDSLYLDFAKRAAPFNNWLDGAREDLADLVIVHEMREIEELVNAHDQFKSTLGDADREFSSINQIEHEVEHLVTSHGLDRELLRNPYTDLSASDIRRKWGEVQNSVPRRDSQLQAELKRQQNNERLRTIFAEKANQVGPWLERELEQVLAIGLGGRGRLEDAIQQLRSIQRNVLGYKPNLDELERVHQEMQENFVFENRKSRYSMESLRVGWETLLTSINKTINEFENQVLLRDSKGISEEQIAEFRASFSHFDKERAGLDPEQLRSCLISVGYTIRPGREGDAELHRVLAHVDPNRMGRVPFEAFLDFMTKENSDQDTVEQMIDSFRILASGKTFITADELERELPRDQAAYCMARMAPSREPGAPPRSFDYVTFSRSLYSQ
Protein: Pentatricopeptide repeat-containing protein 10, chloroplastic (ZmPPR10) (B8Y6I0)
Organism: Zea mays (Maize)
Function: Involved in chloroplast mRNA stability. Binds specifically to two intergenic RNA regions of similar sequence located in the chloroplast atpH 5'-UTR and psaJ 3'-UTR, and serves as a barrier to RNA decay. Binding to a specific site in the intergenic region of the chloroplast atpH is sufficient to block 5'-3' and 3'-5' exonucleases. Acts as protein barrier to block mRNA degradation by exonucleases, and defines processed mRNA termini in chloroplasts. Remodels the structure of the atpH ribosome-binding site in a manner that can account for its ability to enhance translation. Stabilizes a RNA 3'-end downstream from psaI. Binds atpH RNA as a monomer.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:19424177}.
Interaction partners:
- ATP synthase subunit c, chloroplastic
- Photosystem I reaction center subunit IX
- Photosystem II reaction center protein H
- Tha8
- Large ribosomal subunit protein bL33c
- ATP synthase subunit a, chloroplastic
- Cytochrome b6
- CYTB_NTER domain-containing protein.
- ATP synthase subunit b, chloroplastic
- rRNA processing protein-related
Sequence:
MEATGRGLFPNKPTLPAGPRKRGPLLPAAPPPPSPSSLPLDSLLLHLTAPAPAPAPAPRRSHQTPTPPHSFLSPDAQVLVLAISSHPLPTLAAFLASRRDELLRADITSLLKALELSGHWEWALALLRWAGKEGAADASALEMVVRALGREGQHDAVCALLDETPLPPGSRLDVRAYTTVLHALSRAGRYERALELFAELRRQGVAPTLVTYNVVLDVYGRMGRSWPRIVALLDEMRAAGVEPDGFTASTVIAACCRDGLVDEAVAFFEDLKARGHAPCVVTYNALLQVFGKAGNYTEALRVLGEMEQNGCQPDAVTYNELAGTYARAGFFEEAARCLDTMASKGLLPNAFTYNTVMTAYGNVGKVDEALALFDQMKKTGFVPNVNTYNLVLGMLGKKSRFTVMLEMLGEMSRSGCTPNRVTWNTMLAVCGKRGMEDYVTRVLEGMRSCGVELSRDTYNTLIAAYGRCGSRTNAFKMYNEMTSAGFTPCITTYNALLNVLSRQGDWSTAQSIVSKMRTKGFKPNEQSYSLLLQCYAKGGNVAGIAAIENEVYGSGAVFPSWVILRTLVIANFKCRRLDGMETAFQEVKARGYNPDLVIFNSMLSIYAKNGMYSKATEVFDSIKRSGLSPDLITYNSLMDMYAKCSESWEAEKILNQLKCSQTMKPDVVSYNTVINGFCKQGLVKEAQRVLSEMVADGMAPCAVTYHTLVGGYSSLEMFSEAREVIGYMVQHGLKPMELTYRRVVESYCRAKRFEEARGFLSEVSETDLDFDKKALEAYIEDAQFGR
Protein: Oleuropein beta-glucosidase (EC 3.2.1.206) (Beta-glucosidase) (OeGLU) (Q8GVD0)
Organism: Olea europaea (Common olive)
Function: Major beta-glucosidase activating oleuropein into a potent protein cross-linking agent. No activity with rutin, luteolin or p-nitrophenyl-beta-glucopyranoside as substrates.
Subcellular location: Nucleus {ECO:0000269|PubMed:28483880}. Note=Distinctive compartmentalization of the oleuropein/OeGLU dual partner is a requisite to ensure a correct defense system response and to prevent the autotoxicity. {ECO:0000269|PubMed:28483880}.
Interaction partners:
Sequence:
MDIQSNVLTITSGSTPTDTSSNGQAAKSTKERIKRSDFPSDFVFGAATASYQVEGAWNEGGKGMSNWDYFTQSQPGGISDFSNGTIAIDHYNMFKDDVVVMKKLGLKAYRFSLSWPRILPGGRLCHGVSKEGVQFYNDLIDALLAADIEPYITIFHWDIPQCLQLEYGGFLHERVVKDFIEYSEICFWEFGDRVKYWITLNEPWSFTVQGYVAGAFPPNRGVTPKDTEETQKHARLHRGGGKLLAAFKYGNPGTEPYKVAHNLILCHAHAVDIYRTKYQESQGGKIGITNCISWNEPLTDSQEDKDAATRGNDFMLGWFVEPVVTGEYPESMIKYVGDRLPKFSEKEEKLVKGSYDFLGINYYTSTYTSDDPTKPTTDSYFTDSHTKTSHERNKVPIGAQAGSDWLYIVPWGIYRVMVDMKKRYNDPVIYITENGVDEVNDKSKTSTEALKDDIRIHYHQEHLYYLKLAMDQGVNVKGYFIWSLFDNFEWAAGFSVRFGVMYVDYANGRYTRLPKRSAVWWRNFLTKPTAVPLKNEPEKSEDRRKRLRGST
Protein: Transcriptional regulatory protein GltR (G3XCY6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Member of the two-component regulatory system GtrS/GltR involved in the regulation of glucose metabolism and transport, as well as regulation of the exotoxin A gene expression. GltR controls the transcription of genes involved in glucose metabolism (glk and edd/gap-1) and transport (oprB) as well as the expression of toxA that encodes exotoxin A, the primary virulence factor. Acts as a repressor that is released from its target operators upon phosphorylation.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor histidine kinase GtrS
- Glucokinase
- 2-dehydro-3-deoxy-phosphogluconate aldolase
- Phosphogluconate dehydratase
- histidine kinase
- histidine kinase
- HTH-type transcriptional regulator HexR
- HTH-type transcriptional regulator PtxS
- Sensor protein kinase PmrB
- Sensor protein
Sequence:
MSANGRSILLVDDDQEIRELLETYLSRAGFQVRSVSRGADFRQALCEEEASLAILDVMLPDEDGFSLCRWIRSHQRLACMPIIMLTASSDEADRVIGLELGADDYLGKPFSPRELLARIKALLRRAQFTQVRGGDVLAFEDWRLDTVSHRLFHEDGEEFFLSGADFALLKLFLDHPQQILDRDTIANATRGREVLPLERIVDMAVSRLRQRLRDTGKAPRLIQTVRGSGYLLAAQVRPHLQP
Protein: Aminopeptidase, putative (Q57V73)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHRWRPTHCTLQLNFLRPSECGEGQPQVLRAGDAYSGTSTIRYLRCDSKKDEGSTSPAVGSPTRNEPNVAIPRKEDGLHFHAITNIPHSLPKALPLTLQSMKVQMASQRSGAASLKVLKVVDESNSISDGNKNNSGTGPTGASRSDKHVKNCEARKREKQFLKKKQRCKNSDEHNSMGGDGSCEQQADDPGSKYVYFEGGADMPAGSTVLLSIAFTGRVQAWDQGGIYAGEQREGGAGSRVLLTHFEVALARLAFPCPDDPQEYRIVWQLQLLQLPAEYNMVVSNTTEITKKAVGSRGMQYSFAPIGPLPAYVIAFAAFAGAVEVLEEDLQLRGLPAVEYIEQTTNGKSLSGHDGKGNHAMRTVTMRVVTHATSGVAPPVLAQVAHTARDAIRLLEDFFDSPIPLQQLPFCSSHSSNDHWGSDYYCCEWQQYGGGETLTIVVAPTMPYISGMEHHGCIFLNESIYSLTQSVGGTGARGASRSNAPGSETVVEVERVELIVHELVHHWVGNALGMPFVLKEGVCQLMEQCLGDVIMGRPMRKVRPAATGANTTASNINTDSAKTRADDANLVIVDAEKGKEFTFHSYQKALNTLRNVVSVMGFNVFKERMQRMYASEVLEDARSKTSSLPPYVSATKFMAYMNPQDAALYCT
Protein: Cytotoxic granule-associated RNA binding protein 1 (Nucleolysin TIA-1 isoform p40) (TIA1 cytotoxic granule-associated RNA-binding protein) (Q7ZVY0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- GTPase-activating protein
- U1 small nuclear ribonucleoprotein C
- Decapping mRNA 1A.
- Ataxin-2
- RNA-binding protein FUS
- Heterogeneous nuclear ribonucleoprotein C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit B
- U6 snRNA-associated Sm-like protein LSm4
Sequence:
MMDDEQPKTLYVGNLSRDVTEALIMQLFGQIGPCKSCKMIVDTAGNDPYCFVEFFEHRHAAASLAAMNGRKIMGKEVKVNWATSPSSQKKDTSNHFHVFVGDLSPEITTDDIRAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKATYETNTKHLSFDEVVNQSSPSNCTVYCGGVTTGLTEQLMRQTFSPFGQIMEVRVFPDKGYSFVRFNSHESAAHAIVSVNGTSLEGHIVKCYWGKETTDMVSPMQQVQVPQQSKVGFAAQPYGQWGQWYGNAQQISQYVPNGWQVPTYGVYGQAWNQQGFNHLQAGAGWAGVGAVSNGGVVEPAQGVNGTVLANQSTMGTAGYHTH
Protein: Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] (P62983)
Organism: Mus musculus (Mouse)
Function: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Subcellular location: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Small ribosomal subunit protein eS31]: Nucleus, nucleolus {ECO:0000250|UniProtKB:P62979}.
Interaction partners:
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein eS10
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL19
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK
Protein: Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein (Q38FE6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKKRRPIPNPTKISSYFFQQLVSPGATTPDDRKERAQSEQTKRAAASVLSESFTPEGVAAFLQSRSEIERQHSEALEDVLDACWKRVEDIIERNKERRRVIEEDIPQVVAPTGTFTFWTPEGVEQYYSLKTLPVFASDEEGVRSDSNGFGTDNSNAMKSDRNGPAAADHAVISPQGRSAEDKVDGNAAAEGDGRTDPVAEFSSQRACGRAPIVSGAHHTKGRKLTDKELLDESKVPHCLRRLFASLLRRRNEFPKSTTLLFDAIQRTQSERFPEIEAVIEDVPFSMPLHRPFRCIAAFVARSFAENPKGEAPEQAFAATFKTVSKDLKTAYEKLHELKGYVHPVGERTDRAEVIYKTLLGELQGRKSLHETYGIDIEAIMKASAVELSVMEGALKECNETSRRLLATIEDQTAQFIADVHTSLDRREEAIEEIASFYKRDRDRLQSSLQRKIYRAKKSEELQEKCARRIREVTKELYIEQVNYEELLQEILAESLLLQQLDSSYTQLSSSLNNAASVHQESKISSIREALQRSEDVRVHLIEQCQFHINRLKKDEHYRLCRLATNAKDNALCWSRCLNDLSTIYETHFNSLNEKCRVSTQMRYLLSYEKDCVSRDLNQVQKEMEQLDSKWHEISTLLEELGEPVPPLSLLEKDPSCGELRHALTALALTRLVHGESSHLVRPEQWRERTVVATGDGSATANDMS
Protein: Ferry endosomal RAB5 effector complex subunit 3 (Fy-3) (Q9NQ89)
Organism: Homo sapiens (Human)
Function: Plays a role in mast cell degranulation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:D4A770}. Early endosome {ECO:0000305|PubMed:37267905}.
Interaction partners:
- TBC domain-containing protein kinase-like protein
- Protein phosphatase 1 regulatory subunit 21
Sequence:
MKKNRERFCNREREFVYKFKVGSQCLELRVPLKFPVQENASHLHGRLMLLHSLPCFIEKDLKEALTQFIEEESLSDYDRDAEASLAAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYHDLIHSPASETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQHFESQQDLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESVEAIGRIYEEQRKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRNHRSGVKLHRLQTALSLYSTSLCGLVLLVDNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLDSGNQNGGNDDKTKNAERNYLNVLPGEFYITRHSNLSEIHVAFHLCVDDHVKSGNITARDPAIMGLRNILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQFLVPQSISEEMFYQLSNMLPQIFRVSSTLTLTSKH
Protein: Dynamin related protein (F4IFG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSVDDLPPSSASAVTPLGSSVIPIVNKLQDIFAQLGSQSTIALPQVAVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLRLQLVQTKPSSDGGSDEEWGEFLHHDPVRRIYDFSEIRREIEAETNRVSGENKGVSDIPIGLKIFSPNVLDISLVDLPGITKVPVGDQPSDIEARIRTMILTYIKEPSCLILAVSPANTDLANSDALQIAGNADPDGHRTIGVITKLDIMDRGTDARNHLLGKTIPLRLGYVGVVNRSQEDILMNRSIKDALVAEEKFFRSRPVYSGLTDRLGVPQLAKKLNQVLVQHIKALLPSLKSRINNALFATAKEYESYGDITESRGGQGALLLSFITKYCEAYSSTLEGKSKEMSTSELSGGARILYIFQSVFVKSLEVITVCRYLCLVSGAICTEGRQFVSGFQFLEVDPCEDLTADDIRTAIQNATGPRSALFVPDVPFEVLVRRQISRLLDPSLQCARFIFDELVKISHQCMMKELQRFPVLQKRMDEVIGNFLREGLEPSQAMIRDLIEMEMDYINTSHPNFIGGTKAVEQAMQTVKSSRIPHPVARPRDTVEPERTASSGSQIKTRSFLGRQANGIITDQAVPTAADAERPAPAGSTSWSGFSSIFRGSDGQAAAKNNLLNKPFSETTQEVYQNLSTIYLKEPPTILKSSETHSEQESVEIEITKLLLKSYYDIVRKNVEDLVPKAIMHFLVNYTKRELHNVFIEKLYRENLIEELLKEPDELAIKRKRTQETLRILQQANRTLDELPLEAESVERGYKIGSEAKHEELPGTRRSRTETNGNGRLHM
Protein: DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') (P0A8T7)
Organism: Escherichia coli (strain K12)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit omega
- Large ribosomal subunit protein bL12
- RNA polymerase sigma factor RpoD
- DNA-directed RNA polymerase subunit alpha
- Transcription termination/antitermination protein NusA
- Small ribosomal subunit protein uS5
- Transcription termination/antitermination protein NusG
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS3
Sequence:
MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNTELKLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTMPVITEVSGFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGEAPAAPQVTAEDASASLAELLNAGLGGSDNE
Protein: Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (O93309)
Organism: Xenopus laevis (African clawed frog)
Function: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Subcellular location: Nucleus {ECO:0000269|PubMed:9649503}. Chromosome {ECO:0000269|PubMed:9649503}. Chromosome, centromere {ECO:0000269|PubMed:9649503}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Interaction partners:
Sequence:
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKRDKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSSKRETSGEKSRQLRDAQQDARDKMEEIERQVRELKSKISAMKEEKEQLSSERQEQIKQRTKLELKTKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFSSVKQKEESGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAINKDLEETEVNKEKNLEQYTKLDQDLNEVKTRVEELDKKYYEVKNKKDELQSERNYLWREENAEQQSLAAKREDLEKKQQLLRAATGKAILNGIDSINKVLEHFRRKGINQHVINGYHGIVMNNFDCEPAFYTCVEVTAGNRLFYHIVESDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNLRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKVEDELHALEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGTITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTLARSEGLDITIDKTEVESKDLVKSMDRWKNMEKDHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGHKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSTQSSVPSVDQFTGVGIRVSFTGKQAEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELASHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAEQAKDFVEDDTTHG