wanglab/gogpt-training-data huggingface dataset:
Protein: Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein] (Q9WJR3)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Subcellular location: Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04078}; Lipid-anchor {ECO:0000256|HAMAP-Rule:MF_04078}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_04078}. Virion {ECO:0000256|HAMAP-Rule:MF_04078}. Secreted {ECO:0000256|HAMAP-Rule:MF_04078}. Host Golgi apparatus membrane {ECO:0000256|HAMAP-Rule:MF_04078}. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved. {ECO:0000256|HAMAP-Rule:MF_04078}.
Interaction partners:
Sequence:
MGGKWSKSSIVGWPAIRERMRRTEPAAEPAAEGVGAASQDLDRHGALTSSNTDTTNADCAWLRAQEEDEEVGFPVRPQVPLRPMTFKGAFDLSFFLKEKGGLEGLIYSKKRQEILDLWVYHTQGYFPDWQNYTPGPGTRFPLTFGWCFKLVPVDPREVEEANEGEDNSLLHPVCQHGMEDEHREVLKWKFDSQLARRHWARELHPEFYKDC
Protein: Ribonucleoside-diphosphate reductase (EC 1.17.4.1) (A0A8I5Y915)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHKDRLNSAIIYDRDFSYNYFGFKPNYSDISYCLKILTLFLVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS
Protein: Zcf3p (Q59TS6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MELSYRSYQKVLNISLKPKTTHACSKKATAAATTKKIAKPKRDETQIKRRTKTGCLTCRKRKKKCDEDKVNGKCQACTRNFLDCCWPDPNTIKTKNTKPQQQAQQSTEVKPQISPVVRPKKCDINYLLHSQPEPSTPVATVVATQPKVHIPYPSPTLSPVFTESKPNSEVSSFALPPIYSPNYKLQTKDSNVRSV
Protein: Cytochrome c oxidase subunit NDUFA4 (A0A8I6AXF3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVSWDRKNNPEPWNKLGPNEQYKVQMLLLLTYGRPWSPW
Protein: Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein) (A6NK06)
Organism: Homo sapiens (Human)
Function: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P54987}.
Interaction partners:
- Aspartate aminotransferase, mitochondrial
Sequence:
MMLKSITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLGTTTEVFHIASQYSKIYSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDMPKRFHPPSVVGTLGSAAAASKFLGLSSTKCREALAIAVSHAGAPMANAATQTKPLHIGNAAKHGIEAAFLAMLGLQGNKQVLDLEAGFGAFYANYSPKVLPSIASYSWLLDQQDVAFKRFPAHLSTHWVADAAASVRKHLVAERALLPTDYIKRIVLRIPNVQYVNRPFPVSEHEARHSFQYVACAMLLDGGITVPSFHECQINRPQVRELLSKVELEYPPDNLPSFNILYCEISVTLKDGATFTDRSDTFYGHWRKPLSQEDLEEKFRANASKMLSWDTVESLIKIVKNLEDLEDCSVLTTLLKGPSPPEVASNSPACNNSITNLS
Protein: RRM domain-containing protein (Q38BJ0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQTPVSITRRVRVAGIDAEDVAVHGELFNTFSKYGVIEEVLFEEDRDFHSGSVTIQFQRLSSAERLQNDLSSSGRRWIVSYLPPIVHVGEKLLATSLSSLDISLLRSLISQDVEDVAIEEKVLQVPHTLSSEAAEIAATSATPAVIGGHVGNRGAAKVKPPSSRNEGVVRMFLQALSRVKARTIGKYAAVMSFKDVHSANAYLTNNQATLATNNAVYVTHIGPNDELIHALKDILLTRWALKEVKVGSVLRGVVLPQSSEGGVGNTVTSCDVDVGLARKGRTIVVRAKTNFTKVFPWDFVEVKLTSLETAREGNFVEADLCATLNAVNCGLSGTGNNSDLLHCLARRGGPSSLVSSSSCDVLTKSDAPSSSKKELAGRLFKALQERKAAAEGGSDSSRRQRHWSSTAERVHAFPTGIHTLSTISVCILRVDDDGLHARIAAPPHVTTSTIPAASSVEWPVFIPSMFVPSEGGSHWREFAVPGERMSVAVLYATSIGGSEAALRLVASKRDAEMRRASFTLSHGAFPDEEEQRRRSGQHTNESLLLPGTSFSGTRVVWLPSTPSTDDPVYIVLPASTSPPQLFTLSIFMHETCPTSGSTHASAVDAVMSTLVVSEVVHEPCRGYYAVAVEEPTYRQQQEERRTVQSQVESEQEKRVQRILAEALAGCKSGQSNAKAEVLDEVGQKRQRSPGV
Protein: Alternative oxidase (EC 1.-.-.-) (A0A1D8PEM4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Cytochrome c
Sequence:
MIGLSTYRNLPTLLTTTTVISTALRSKQLLRFTTTTSTKSGSSTSTTSTIVGNSNPKSPIDEDNLEKPGTIPTKHKPFNIQTEVYNKAGIEANDDDKFLTKPTYRHEDFTEAGVYRVHVTHRPPRTIGDKISCYGTLFFRKCFDLVTGYAVPDPDKPDQYKGTRWEMTEGKWMTRCIFLESIAGVPGSVAGFIRHLHSLRMLTRDKAWIETLHDEAYNERMHLLTFIKIGKPSWFTRSIIYIGQGVFTNIFFLVYLMNPRYCHRFVGYLEEEAVRTYTHLIDELDDPNKLPDFQKLPIPNIAVQYWPELTPESSFKDLILRIRADEAKHREINHTFANLEQWQDRNPFALKIKDSDKPQPNYNLDVTRPQGWERKDLYL
Protein: Cytochrome c 2.1 (P19974)
Organism: Caenorhabditis elegans
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c domain-containing protein
- Cytochrome c oxidase subunit 1
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 3
- Cytochrome b
- Cytochrome b-c1 complex subunit 6
- Cytochrome c oxidase subunit 4
- Cytochrome b-c1 complex subunit 8
- Probable cytochrome c 2.2
Sequence:
MSDIPAGDYEKGKKVYKQRCLQCHVVDSTATKTGPTLHGVIGRTSGTVSGFDYSAANKNKGVVWTKETLFEYLLNPKKYIPGTKMVFAGLKKADERADLIKYIEVESAKSL
Protein: WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (O88342)
Organism: Mus musculus (Mouse)
Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage. Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome {ECO:0000250|UniProtKB:O75083}.
Interaction partners:
- Cofilin-1
- Cofilin-2
- F-actin-capping protein subunit beta
- Destrin
- Filamin-A
- Caspase-4
- Actin-related protein 3
- Adenylyl cyclase-associated protein 1
- Actin, cytoplasmic 2
Sequence:
MPYEIKKVFASLPQVERGVSKILGGDPKGDHFLYTNGKCVILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHRNGGKSYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEVVAVHPGGDTVAVGGTDGNVRVYSILASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Protein: U2 small nuclear ribonucleoprotein 40K (Q388G6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein, putative
- Small nuclear ribonucleoprotein Sm D2
- Sm protein B
- Sm protein G
- PHD finger-like domain-containing protein 5A
- Small nuclear ribonucleoprotein SmD1
- SURP motif domain-containing protein
- Small nuclear ribonucleoprotein SmD3, putative
- Splicing factor 3B subunit 1, putative
Sequence:
MRLTLDTIRRAPQFTNALRQRELDLRGLGITVLEEHTLTFLNDSFDVLNLSQNPLARLEYFPGDSAPLATAAAQNGSAKPASRMMLRLQTLVVHRNRLTHVSEATCATVLPNLRAFVADHNEFRELRDLLFLSHWKKLEILSIEHNPITISEDNARLRAFVVFLCPTLKLVNYQRVTQVDRQNVETMRKEFVGLVEGWRRLEAKQLLQQNSAPTEADASASESVKKIRKRSRHAREAASKNGSADTAPEPAASKVETFATPVAAEAGEEEEASNALQARLEALEEKMAAAETEEELMELQQELTELETLMKHQQASKGTKKTRTS
Protein: Myricetin O-methyltransferase (EC 2.1.1.267) (CrOMT2) (Flavonoid O-methyltransferase) (Q8GSN1)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Methylates myricetin and dihydromyricetin at 2 sites. Inactive towards 16-hydroxytabersonine, the phenylpropanoids 5-hydroxyferulate, caffeate and their CoA-esters, flavones and flavanones possessing 2 or 3 B-ring hydroxyl groups.
Interaction partners:
Sequence:
MELQSSEIRNAQAHFFTQVFSFTSMSSLKCAVQLGIPDAIHSHGKPMALSDLTNSLPINPSKAPYIYRLMRILVAAGYFSEEEKNVYSLTPFTRLLLKNDPLNSISMVLGVNQIAELKAWNAMSEWFQNEDLTAFETAHGKNFWDFGAEDKYGKNFDGVMAADSILVSKMLIPEFNYLFEGLDSLVDVGGGTGTIAKAIAKSFPDLKCTVFDLPHVVANLESTENLEFVGGDMFEKIPSANAILLKWILHDWKDEECVKVLKMCRKAIPEKEKGGKVILIETVLMDSKKHENEEAVKAQISSDIDMMVFFTAKERTEEEWATLFREAGFSGYKIFPMIDFRSPIEVYP
Protein: DNA polymerase II (Pol II) (EC 2.7.7.7) (P21189)
Organism: Escherichia coli (strain K12)
Function: Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
Interaction partners:
- Beta sliding clamp
- DNA polymerase IV
- DNA polymerase I
- Protein UmuC
- Protein RecA
- UvrABC system protein A
- Exodeoxyribonuclease III
- Protein UmuD
- LexA repressor
- Flap endonuclease Xni
Sequence:
MAQAGFILTRHWRDTPQGTEVSFWLATDNGPLQVTLAPQESVAFIPADQVPRAQHILQGEQGFRLTPLALKDFHRQPVYGLYCRAHRQLMNYEKRLREGGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTIVNARLKPHPDYRPPLKWVSIDIETTRHGELYCIGLEGCGQRIVYMLGPENGDASSLDFELEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGRDNSELEWREHGFKNGVFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQELLGEGKSIDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPVDRHGGSVAAFGHLYFPRMHRAGYVAPNLGEVPPHASPGGYVMDSRPGLYDSVLVLDYKSLYPSIIRTFLIDPVGLVEGMAQPDPEHSTEGFLDAWFSREKHCLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGTTACRFFDPRLASSITMRGHQIMRQTKALIEAQGYDVIYGDTDSTFVWLKGAHSEEEAAKIGRALVQHVNAWWAETLQKQRLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPLAQQFQQELYLRIFRNEPYQEYVRETIDKLMAGELDARLVYRKRLRRPLSEYQRNVPPHVRAARLADEENQKRGRPLQYQNRGTIKYVWTTNGPEPLDYQRSPLDYEHYLTRQLQPVAEGILPFIEDNFATLMTGQLGLF
Protein: C6orf25 (Chromosome 6 open reading frame 25, isoform CRA_h) (cDNA FLJ35073 fis, clone PLACE6000630) (B0V023)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFALSPPHSSTCENRAPEASKGGRAQDSRGPGPGTEPALCGSGPSSPQQAPPAVHSGPC
Protein: CLAVATA3/ESR (CLE)-related protein 4 [Cleaved into: CLE4p] (Q8S8N0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate.
Subcellular location: [CLE4p]: Secreted, extracellular space {ECO:0000269|PubMed:12602871}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- Small polypeptide DEVIL 11
- Large ribosomal subunit protein uL24y
- Dentin sialophosphoprotein-like protein
- Small ribosomal subunit protein mS78
- Small polypeptide DEVIL 4
- Alpha/beta-Hydrolases superfamily protein
Sequence:
MASFKLWVCLILLLLEFSVHQCRPLVAEESPSDSGNIRKIMRELLKRSEELKVRSKDGQTVLGTLDSKRLSPGGPDPRHH
Protein: Lipase 1 (DmLip1) (EC 3.1.1.-) (O46107)
Organism: Drosophila melanogaster (Fruit fly)
Function: Could be a digestive enzyme.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Phospholipase B1, membrane-associated
Sequence:
MRCSLRMQLLLLLGLCVFISRIQGQLIGGEEDEEDEEEEEEEEESVEDETPEDRLQRKNIKQDSTLSVDKLIAKYGYESEVHHVTTEDGYILTMHRIRKQGAPPFLLQHGLVDSSAGFVVMGPNVSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFSWHEIGMYDLPAMIDHVLKVTGFPKLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAPAVYAKETEDHPYIRAISLYFNSLVGSSIREMFNGEFRFLCRMTEETERLCIEAVFGIVGRNWNEFNRKMFPVILGHYPAGVAAKQVKHFIQIIKSGRFAPYSYSSNKNMQLYRDHLPPRYNLSLVTVPTFVYYSTNDLLCHPKDVESMCDDLGNVTGKYLVPQKEFNHMDFLWAIDVRKMLYRRMLQVLGKVPEGSPEEANRSRREIRGKFIRS
Protein: Arg81p (A0A1D8PEG7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MSSPSILSKNIEDKSSTTEIAPPPTQPQSQPVTTTTTTTRRSKTFTGCFTCRSRKIKCDLTKPQCEKCTRAGLICAGYDIKLRWSDPIQYIPTKTGNVKSQPIKFTNKDDEQLDENNNSKNNNNSSSEFFQRRKVGFVKWDEPYETYEDMDSDLSILHGSGEDPIVKLSGETKLKGPFGVFKGEPSPQQQNNIISQEISLKSKKRRLNNSHNDTNVIATTTTTTTTTGTTSNVSNTYTNGSSPLVHGHNFTTTTTTESNSQPHGYNLETGIPHSDQPQDSQWISNELKDAALVTAAALDTQFLDLMFNFNSNIPTDDTSNNINNNTTTNTHTHTDNQTNNNNNNTGHSSIMDEFNNPDFLNLLFHKNSQLAITTPQPHIGTTTHTTTPQLSHSNSSISLANILNQNQGANNNSNSILMDPTYYSNFSNFFYNNPYQSNENLEIDLHAKSIDHDHDHDHDEDEDDESPEEVDGNDSKLLQFIMKIVKNPTNLPFDLSLPSNSNEQQQQQQQQQQQEHHHHHQIGIPVNALQVQPLTRYLLNYYVTNVADLMTVIPLTESPWKTIYFPRALMALGELSALGKTSTAKNALLNALLAVSAFNLQSKFPKNSEPMRFYLNLGIALRNQASLFIKQLLHNKRNNKRNKTNGIEYCINHEKYKDVLCAVLSMISVDLVWGTMQDTRIYITWCGKVIIAKMQNKKKLSTKASILHRIFSNLKLIQDSTCLDIDSINEDFETNYYGIGIGTGTGIGYDVSGDKYVQQKLDNSDGDATTTTTAVVDDHKKVRKTRIDFIVNNTFTNKKQTKTTTTTTTNKSKSSITTSPSFVNKKLINTMKNDESFATDALYGLPYSLIVLFSETVELLRTKIYYRDNPKAAARIAMKLSNHEKEFNDRIEELNEKLENWTLDWQLYEQQQQQQQNMTTTKAKTRSTTPTSSPTPTDGKPENEEPTTVGDDNDNDDNNEFDHKFYSPMHKATYHHIMSFYHALMIYFNRLIKQIPAENLQNQVKKTLQHLNAIQKLIDDKEANIIPLFWQGFIAGCEAIEPDLQLAFKQWGADIAKYLGSYWGARQIMMEVWRRKRANEIKDDWISVIHDWEMNLMLA
Protein: Uncharacterized protein C663.15c (O74521)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- PX domain-containing protein C1450.12
- Uncharacterized membrane protein C663.14c
- Meiotically up-regulated gene 122 protein
- Sorting nexin-12
Sequence:
MDSLTSILLLLELQHEFSGLKVPGRLAKFGPPFRPSEEFADAEDSPVMKMIAQSYIFTPTLPGVNKAPPEFWSDKLQPLLETIGKHNLSDSYDHGRVSKRKMVGFAVVVVLHVLSKGLLGKATPLSEDRKPTSNNEEEDDADEAKSSNADSSTDSVQKSLANVNMDDANGPERLHYPSVKRLREAYSLLVYGDGLQQALDRISVSEDVDSWDEPLRSVIENIRYTIAVILHFSFVTVDAIPESPHLVSNRKGPEGVVERLYNRIPWFLTRQVLRVGNAGLLMSGLTRLFLMKPLSWFGESRNLLQTMLAGIFNADLEHSESTMVETDAEFEDDAKWETMRKALQWFTQLSRTEQDDVRSQSINKELNITIAILEAYEAQQTETTETEGVDKEDSDKASSVQGNEDEVPDTASETEHSEIEDFHFDPYSEKGVHIAMRYFDAALTHRDRECLIHDLCDNDQLNDVVREFMNAFYNIIYEAHQAADFSQAIYDFQYFLWDVIQLSKAGAPLVKFINLVERYQSCFVRFIHRLVVNAPDLCGEWCDWYRHCLKQFSVEVKTPDAVDVAHKALNTLDEETKHQVLEEIGDYVKELDEESKKAIENKDSTSEWLLHLYNFFGSAIITPTTAHGVPQPQLPNCGMKLNRTKEKLLTPFRNLLMEQLNELQAKNQETPSEMTSTE
Protein: ATP synthase subunit a, chloroplastic (ATP synthase F0 sector subunit a) (F-ATPase subunit IV) (P0C2Y7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01393}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01393}.
Interaction partners:
- ATP synthase subunit alpha
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit c, chloroplastic
- ATP synthase subunit b, chloroplastic
- Os02g0750100 protein
- F-ATPase gamma subunit
- Os06g0714700 protein
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit beta, chloroplastic
- Os06g0646500 protein
Sequence:
MNIIPCSIKTLKGLYDISGVEVGQHFYWQIGGFQIHAQVLITSWVVITILLGSVIIAVRNPQTIPTDGQNFFEYVLEFIRDLSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSAAYFYAGLSKKGLSYFEKYIKPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
Protein: ATP synthase subunit b, chloroplastic (ATP synthase F(0) sector subunit b) (ATPase subunit I) (P0C2Y9)
Organism: Oryza sativa subsp. indica (Rice)
Function: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01398}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01398}.
Interaction partners:
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit alpha
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit c, chloroplastic
- F-ATPase gamma subunit
- ATP synthase subunit beta, chloroplastic
- ATP synthase subunit delta', mitochondrial
- Uncharacterized protein
- ATP synthase subunit C, plastid
Sequence:
MKNVTHSFVFLAHWPSAGSFGLNTDILATNLINLTVVVGVLIYFGKGVLKDLLDNRKQRILSTIRNSEELRRGTIEQLEKARIRLQKVELEADEYRMNGYSEIEREKANLINATSISLEQLEKSKNETLYFEKQRAMNQVRQRVFQQAVQGALGTLNSCLNTELHFRTIRANISILGAMEWKS
Protein: Mitochondrial import inner membrane translocase subunit TIM44 (O43615)
Organism: Homo sapiens (Human)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10339406}; Peripheral membrane protein {ECO:0000269|PubMed:10339406}; Matrix side {ECO:0000269|PubMed:10339406}. Mitochondrion matrix {ECO:0000269|PubMed:10339406}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit TIM14
- Stress-70 protein, mitochondrial
- GrpE protein homolog 1, mitochondrial
- Heat shock 70 kDa protein 4
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit Tim10
Sequence:
MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIITFQAQLVMVVRNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQIL
Protein: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) (Q9D6R2)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Isocitrate dehydrogenase subunit
- Isocitrate dehydrogenase subunit gamma 1, mitochondrial
- Aconitate hydratase, mitochondrial
- Probable isocitrate dehydrogenase gamma 2, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- 2-oxoglutarate dehydrogenase complex component E1
- Succinate--CoA ligase subunit beta, mitochondrial
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
Sequence:
MAGSAWVSKVSRLLGAFHNTKQVTRGFAGGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD