wanglab/gogpt-training-data huggingface dataset:
Protein: Sec-independent protein translocase protein TATA, chloroplastic (Protein THYLAKOID ASSEMBLY 4) (Protein TWIN-ARGININE TRANSLOCATION A) (Q9XFJ8)
Organism: Zea mays (Maize)
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000305|PubMed:10525534}; Single-pass membrane protein {ECO:0000305|PubMed:10525534}. Note=The C-terminus is located in the stroma.
Interaction partners:
- Sec-independent protein translocase protein TATC, chloroplastic
- Sec-independent protein translocase protein TATC chloroplastic
- Preprotein translocase subunit SECY, chloroplastic
- GMP synthase
- Chlorophyll a-b binding protein M9, chloroplastic
- Chlorophyll a-b binding protein, chloroplastic
- Chlorophyll a-b binding protein 48, chloroplastic
- Chlorophyll a-b binding protein 1, chloroplastic
- Sec-independent protein translocase protein TATB, chloroplastic
- GroES-like zinc-binding alcohol dehydrogenase family protein
Sequence:
MGIPVVVPVAAAYSCSSSLAAPPRAAAAAARAPSRAHVAAAGMSSRASSFVGGSGGDLAAVAASVAARPRRAGSGGGGALGCKCLFGLGVPELAVIAGVAALVFGPKQLPEIGRSIGKTVKSFQQAAKEFETELKKEPGEGGDQPPPATPTAVSGGEEKGLEASSSKESA
Protein: ER membrane protein complex subunit 2 (O76630)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side {ECO:0000256|RuleBase:RU367091}.
Interaction partners:
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 4
- Membrane magnesium transporter
- MPN domain-containing protein
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 7 homolog
- Derlin-2
- Erlin
Sequence:
MVETEWTQVSYDEGRQALKKWRECGVRRSDEVVEIWEHVISRSPASLGDEQWAVLEQVCIAALDAARVDLAQDCIDQLHAQFPKSNRVLKLKAMQLESTEHYQKALDIYERLVEDEPNNNSFRKRKVAVLLAQGKRLDAIRAINDYLKIFLNDPEAWLQLSELFLLENDVAKAVHCLEECVLISPLNSMYFRRLADLRYTQGGAENVELARSYYERALKINPTDLRSQYGILLSNNLIAATTKNATEKKKAGAAAVDAIDNLVNRYQKISPKSNPESDGILNCLEAMKVTVGSK
Protein: Protein sdf-9 (Synthetic dauer formation 9) (G5EGA9)
Organism: Caenorhabditis elegans
Function: Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12783794}. Cell membrane {ECO:0000269|PubMed:16839187}; Peripheral membrane protein {ECO:0000269|PubMed:16839187}. Note=Localizes to dendrite-like structure in XXXL/R cells. Membrane localization is daf-2/InsR-independent. {ECO:0000269|PubMed:12783794}.
Interaction partners:
- Enhancer of AKt-1 null
- Protein eak-4
- MTOR-associated protein MEAK7
- 3-ketosteroid oxygenase
- Serpentine Receptor, class H
Sequence:
MEKYSIRSNIVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWSYGHLQVERKSYAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGALNMINPASALFRSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPLIAYSESCFVKWSSMDKEIEKFINTKTWFLNESSRNKFLRSVMPPVV
Protein: Neugrin (FI58Gm) (Neurite outgrowth-associated protein) (m-Neugrin) (Q99KS2)
Organism: Mus musculus (Mouse)
Function: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NPE2}. Secreted {ECO:0000250|UniProtKB:Q9NPE2}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9NPE2}.
Interaction partners:
- FAST kinase domain-containing protein 2
- Pseudouridylate synthase RPUSD4, mitochondrial
- Mitochondrial mRNA pseudouridine synthase Rpusd3
- Pseudouridylate synthase TRUB2, mitochondrial
- RCC1-like G exchanging factor-like protein
- Pentatricopeptide repeat-containing protein 1
- Actin-related protein 8
- GTP-binding protein 10
- Probable ATP-dependent RNA helicase DDX28
Sequence:
MALSLSLFLGGRVRTSLARCGFASQVMAGPGSVSCEPDPDSDWEPEERELQEVESALKRQKKAMRFQKIRRQMEAPGAPPRTLTWEAMEQIRYLHKEFAESWSVPRLAEGFDVSTDVIRRVLKSKFVPTLEQKLRQDQKVLKKAGFTREIGQLPVSEDTLKALSAGRSVSGLLMAGDEVSSKSQNHSTALKVAKSHPHSTDAQKKREGRDKRIQVLEESLVPATTALGHQRELQKSATSDSEATGRAGSDTLPSAVLLEELKPGEPGDQSFSSKVVQRGHDFFDSNGNFLYRI
Protein: Sulfite oxidase, mitochondrial (EC 1.8.3.1) (Protein shopper) (Q9VWP4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required in ensheathing glial cells for normal larval locomotion. Oxidizes sulfite which is required to maintain glutamate homeostasis and as a consequence, neuronal network function.
Subcellular location: Mitochondrion intermembrane space {ECO:0000305}.
Interaction partners:
- NADH-cytochrome b5 reductase
- Persulfide dioxygenase ETHE1, mitochondrial
- Sulfurtransferase
- PAPS synthetase, isoform D
- Molybdenum cofactor biosynthesis protein 1
- Cytochrome c-2
- Cytochrome c-1
- GH21160p
- Molybdenum cofactor sulfurase
- Molybdenum cofactor synthesis protein cinnamon
Sequence:
MRLLRPSWAGLLRGRHHQHQRHHRRLLLTTSRGSNGEREEQQHSQWSSPGSRSEQLFYAAFWAGGLTLGYHWLTDKKNHVLLEGQKVASEEELEATARLWHVTNRRELPTYRAEEVEQHNSVEKRIWVTYGLGVYDVTDFVENHPGGDKILMAAGSAIDPFWGIYQQHNTLEVLELLEGFRIGNLEGLVVTNVDDELGSPWSQEPQRHALLKPASKRPFNAEPPIGLLAEQFYTPNELFYVRNHLPVPVINPEDYELEIEGGAKDKTLTLDGIKALPKHSVTAAIMCGGNRRSEMTKVKAVKGLSWGAGAVGNAKWSGARLCDILREQGVQPDETKHVIFEGADLDPTSHPYGASIPLAKALDPRGDVILAYEMNDEPLSRDHGFPIRVIVPGTVGARNVKWLTRIVVADKESDSHWQQNDYKGFSPSTDWDTVDFSKSDAIQAMPVTSAICTPQPGARVKVDDDEGHITVRGYAWSGGGRKIVRVDLTNDEGVSWHVAELEQEEMPDGRHYGWSLWTARLPVSEAQRRAGDVEIWAKAVDSAYNVQPEKFEHIWNLRGVLANAYHKVKVKII
Protein: Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) (P06396)
Organism: Homo sapiens (Human)
Function: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Subcellular location: [Isoform 2]: Cytoplasm, cytoskeleton.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted.
Interaction partners:
- Actin nucleation-promoting factor WASL
- Src substrate cortactin
- Actin, alpha skeletal muscle
- Hematopoietic lineage cell-specific protein
- Profilin-4
- Profilin-3
- Profilin-1
- Twinfilin-2
- Talin-1
- Talin-2
Sequence:
MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPNSMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
Protein: Prothrombin (EC 3.4.21.5) (Coagulation factor II) (E7FAN5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Antithrombin-III
- Fibrinogen alpha chain
- Heparin cofactor 2 isoform X2, member 1)
- Fibrinogen beta chain
- Fgg protein
- Tissue factor
- Glia-derived nexin precursor
- Proteinase-activated receptor 4
- Thrombomodulin.
- Coagulation factor V
Sequence:
MLQVFSGLQAQSLSRMGAKLAPLLLFLIFGQVFHLTLCHNVFIDSKEASQIIRAKRANTVFEELKPGNLERECVEEICDHEEAREVFERVDKTEIFWAKYLGCEGTTLSRTPQNINSLRICATTEGDCFINIGAKYAGKVSVTKSGKACQYWKSNFPHKIDEFNVTQLKLPENFCRNPDKHKDGPWCFTRDPTVRRETCNVPKCGEAVVPPPKAPTAKPEQRHVISKCLPGNGETYTGELFVTLGLHTCLQWSSAEVQALIKKKELLPQVQLVKNHCRNPDGDMEGPWCYIKAASGNITIDYCDLELCDAPLDKFVEEGGGRERTTLDQRKAFFNPRSFGNGELDCGERPLFEKINKADKNEKELLMSYTGSRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISDEWILTAAHCILYPPWNKNFTINDIIVRLGKHSRTKYERGIEKIVAIDEIIVHPKYNWKENLNRDIALLHMKKPVVFTSEIHPVCLPTKSIAKNLMFAGYKGRVTGWGNLRESWTSNPTNLPTVLQQIHLPIVDQSICRNSTSVIITDNMFCAGYQPDDSKRGDACEGDSGGPFVMKSPSDNRWYQIGIVSWGEGCDRDGKYGFYTHLFRMRRWMKKVIEKTDSGDDE
Protein: LOB domain-containing protein 4 (ASYMMETRIC LEAVES 2-like protein 6) (AS2-like protein 6) (Q9SHE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- WUSCHEL-related homeobox 14
- Dof zinc finger protein DOF5.3
- Leucine-rich repeat receptor-like protein kinase TDR
- WUSCHEL-related homeobox 4
- Protein BEARSKIN1
- CLAVATA3/ESR
Sequence:
MKESSRKQGAASPCAACKLLRRRCAQDCVFSPYFPADEPQKFANVHRVFGASNVNKMLQELPIHQRGDAVSSMVYEANARVRDPVYGCVGAISSLQQQIDVLQAQLALAQAEVVHLRVRQSTNFPGHGLCPDSPSSSGSPSSKQVSPQDNKGMFSHMDIVDEASLGESMWSC
Protein: Regulator of G-protein signaling 11 (Q9Z2H1)
Organism: Mus musculus (Mouse)
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-5
- Regulator of G-protein signaling 7-binding protein
- Regulator of G-protein signaling 9-binding protein
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- G-protein coupled receptor 179
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MERVVVSMQDPDQGVKMRSQRLLITVIPHAVAGRDLVEWLVQKFCILEDEALHLGTLLAQHGYIYPLRESRDLTLRPDETPYRFQTPYFWTSTMWPAAELDYAIYLAKKNIQKQGALVDYEKEHYALLHKKINHAWDLVLMQAREQLRAAKQRRKGDRMVISCQEQTYWLVNKPPPGAPNILEQGPERGSYNPSHMQMSSDFYKCEIECFRKALGRNRVKSSACLEAYLKFSSQHGPHDPIMSGCLPSNPWITDDVTYWAMNAPNVAAPTKLRVERWSFSFRELLDDPVGRAHFMDFLQKEFSAENLSFWEACEELRFGGQAQVPTLVDSVYQQFLAPGAARWINIDSRTMERTLEGLRQPHRYVLDAAQLHIYMLMKKDSYPRFLKSDIYKGLLEEAVIPLETKRWPFPFLRKPLHSSPSPALQSTPREPAATSSPEGADGE
Protein: M-factor (P34068)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- M-factor
- Pheromone P-factor receptor
- Pheromone M-factor receptor
- Mating factor M secretion protein mam1
- Carboxypeptidase sxa2
- Mating-type M-specific polypeptide Mc
- Pro-P-factor
Sequence:
MDSMANSVSSSSVVNAGNKPAETLNKTVKNYTPKVPYMCVIA
Protein: D-xylulose reductase A (EC 1.1.1.9) (Xylitol dehydrogenase A) (Q86ZV0)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Interaction partners:
- Probable D-xylulose kinase A
- Probable NAD
- Alcohol dehydrogenase-like C-terminal domain-containing protein
- Xylanolytic transcriptional activator xlnR
- Alpha-L-arabinofuranosidase B
- Probable alpha-L-arabinofuranosidase A
- Probable feruloyl esterase C
- Endo-1,4-beta-xylanase A
- Probable endo-1,4-beta-xylanase B
- Exo-1,4-beta-xylosidase xlnD
Sequence:
MGAPPKTAQNLSFVLEGIHKVKFEDRPIPQLRDAHDVLVDVRFTGICGSDVHYWEHGSIGQFVVKDPMVLGHESSGVISKVGSAVTTLKVGDHVAMEPGIPCRRCEPCKEGKYNLCEKMAFAATPPYDGTLAKYYVLPEDFCYKLPENINLQEAAVMEPLSVAVHIVKQANVAPGQSVVVFGAGPVGLLCCAVARAFGSPKVIAVDIQKGRLEFAKKYAATAIFEPSKVSALENAERIVNENDLGRGADIVIDASGAEPSVHTGIHVLRPGGTYVQGGMGRNEITFPIMAACTKELNVRGSFRYGSGDYKLAVNLVASGKVSVKELITGVVSFEDAEQAFHEVKAGKGIKTLIAGVDV
Protein: Uncharacterized protein (Q57XW6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRGTVLIFGRKFSWNAVVDEYGHRLPQCAGLSSTRKRLLLKDWRYFTSTGSEESLTTFFRSGHKCTNSLEDGDDAHAHVKGNADVVYNDGQQGRKIHRALRGVAEFIAATGTFDDVCAPGERGYSDVSLAVEGLKRARLAVEYTGTVLSLSNDRRDGMLAQALSRNRRSDEEVVNQQHLRSHCGEVLSPLEVVAIAQWCAWHVRTSLKGAKHHQGTPTKSQGDAETARCIVSVLTRFLSILVEEGLRRWAVDSVACELELSDLVCIVTEEALLVLRDNKKACTSVKFATPLPTCSVGCSATSEQTALMAEHLKPGMRTWEDLCFGVKAQEALLCSQRERWQRALRLLLDVQRWNVLATTKNCTTSTEEVLTNECEGKCQLLASKALNILSMIPHGVVQTLQYILAQHGQWRLCMMLWKRGIRLPSGDAPTCNETEEERPPHSLLLHPAGLNTVITALALVNGRPSKHSFTAATSSLLCATATAGGTEGVDAKLLRLLLHLGVIPHRHFTVTEFATLLKDAFGLHLQSSHVDSILSPAAVWRCSEGLPSHMREVLCLMCFRVVARSGLAHTLMLEDLYVIICLSYRTVLSQMCRPMAESSTPSTQRGRENISNCAVPNIQGRCEPSRNGLLTVGLAAATRRTAVFAEEDIRTITEAFLSCSSRLLVPSERAKSFQREEEVYAGVNYTDLHLYRTLVNVRIGRNGSTAMLFTVSSMLTRLLTVMPHVFTLGTVWRGALCALSTNYQLDACDHHLAAAASVFAEVIVGTARTSNKDALVDTLVYLAPLLSPFAIGQIVKGPVGRRLSWTHCLALLPYAPCASGAQRLMLRRIVKDCDVEGMSFVYSLLRMSTPPLQLLPQASPAVSTDVCTLLLLTERSWMRALQAYGRFDLRVQRACAPHIVRLIVTAGAWLPHTHNTGGDANCSHCLNGFDSLLHTALQATEGSRVAEEVLQLSLKRGLWAGGLAFHQRLQHEHSGILLGNGRIKTCAAMLFKGLLSHTALAHTIAVALKHARAARWAEACMVLLEDDGSHDGAEESGSVTHFGVTSLHPAHWSSLFRDKVPPQLSHLAHTVRYSMLCCPGLWQRALKWLPPQALPFPVHHQLLLARVSGLPIGVAAACDAVTPKVETTTPLVGPPLSPMSLVQVALQEKLRCSKASATVASQAEVERTLRVLRQRGQWEQAVLVYEHSLACRCFPHSASATVVGACLPSWQASLSCFAHMSQRMRPDVATASLALQACRRGRKWKIALRVLQQCVLTSASRSAGEVVRTAPQLINYAIQAVLGAGVWDAALNVVRQYGQTMSPLLANTILLTYVRAERYDEAVNFFYGCVRRGVRLHDQSLDLVVAASQAVSAEYHDLARFVGVMASTLEDFCHVHGVLLQHVLLVCRSISVPPHALVLSFSCDQTGVSASMVSDDVINATDSIW
Protein: V-type proton ATPase subunit D (V-type proton ATPase subunit d) (Vacuolar proton pump subunit D) (Q6P503)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029434}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029434}.
Interaction partners:
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit F
- V-type proton ATPase subunit C 1
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit H
- V-type proton ATPase subunit
- Vacuolar proton pump subunit B
Sequence:
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKSEKDLERRRAAGEVMEPANLLAEEKDEDLLFE
Protein: Uncharacterized oxidoreductase C215.11c (EC 1.-.-.-) (O94315)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized oxidoreductase C8E4.04
- Putative pyridoxal kinase C6F6.11c
- Putative pyridoxal kinase C18.10
- Probable pyridoxamine 5'-phosphate oxidase
- NAD/NADP-dependent indole-3-acetaldehyde reductase
- Zinc-type alcohol dehydrogenase-like protein C2E1P3.01
Sequence:
MSKTAASSAVDASQAGTVKVGDMVVNRMGFGAMRVTGDGIWDEPKDKEACIATLKRLPELNINFIDTADSYGPEVSENLLREALYPYKGLIIATKGGLVRTGPNEWHPCGAPKFLRQEVLMSMRRLGVKQIDLWQLHRIDPKVPRKDQFSEIAAMKKEGLIRHVGLSEVTVDDIKEAEQYFPVVSVQNLFNLVNRKNEKVLEYCEQKGIAFIPWYPLASGALAKPGTILDAVSKDLDRSTSQIALSWVLQRSPVMLPIPGTSKVDHLEENVKAAGIQLSSEVFAKLDEEGKSEDAKRQEEEKKKSS
Protein: Type IV secretion system protein VirB3 (Q2GKX3)
Organism: Anaplasma phagocytophilum (strain HZ)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Type IV secretion system protein virB4
- Type IV secretion system protein VirB6-1
- Type IV secretion protein VirB8-1
- Type IV secretion system protein VirB6 family
- Type IV secretion system protein VirB10
- Type IV secretion system protein VirB4-2
- Type IV secretion system protein VirB6 family
- Type IV secretion system protein VirB8-2
- Type IV secretion system protein VirB6 family
- Type IV secretion system protein
Sequence:
MSGSVKADQLFKGLTRPTMLFGVSYTFAIMNFMLSIMIFMYSNDFRVLFILAPGMHGLGFIASAKDPLFMDLLIIRMQKCSKCLNRFYHNSNSYDVM
Protein: Non-reducing polyketide synthase nscA (EC 2.3.1.-) (Conidial yellow pigment biosynthesis polyketide synthase nscA) (Neosartoricin biosynthesis protein A) (Q4WA61)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of neosartoricin, a prenylated anthracenone that exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent. The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone. The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation. The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5. The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2. There is no gene encoding O-acetyltransferase in the nsc gene cluster; thus, the last step of 2-O-acetylation leading to neosartoricin may be catalyzed by an unidentified O-acetyltransferase.
Interaction partners:
Sequence:
MATPRGQTVWFGNEFPNDDLKDLFRRLHQHSKDRRFRLLSVFLEESTAILKEEVANLPQQLQELVPHFDTACTLPEVDFRQGPLGAAMESALLTILELGMLIGHYEAEDIEWDLDPSRTILAGLSIGILAGAAVALSSSLADVAKVGAESVRVSFRLGVYVADISTKLEAPQSDGTLQSWAHVVTGMSHEAVQEELSQYNAVTQNPEITKVFVSAADKTSVSVTGPPSRIKAAFQHSPSLRYSKSLPLPVYDGLCHAAHLYSQDDIEIVINSAKSVIPTSRPVRLPLISSQTGKPFAAKTAGELFLEIGTELLTGTIFLDTVTAGILEHVKLQEPTGNYEIVSFRMSQVLNGILTAIETDFPELGRARRDMVSWVHGDYGARRPSSYAASKLAIVGMACRLPGGANDPELFWELLEQGRDTLTTVPPDRFDLNTHYDPTGKTENATQTPFGNFIDRPGYFDAGFFNMSPREAEQTDPMHRLALVTAYEAMEMAGMVPGRTPSTRPNRIGTFYGQASDDWRELNASQNISTYAVPGGERAFANGRINYFFKFSGPSYNIDTACSSGLAAVQAACSALWAGEADTVIAGGLNVITDPDNYAGLGNGHFLSKTGQCKVWDKDADGYCRADGIGSVVIKRLEDAEADNDNILAVILGARTNHSAEAVSITHPHAGAQKANYRQVLHQAGVNPLDVSYVELHGTGTQAGDAVESESVSDVFAPSTPRRRPDQRLYLGAVKSNIGHGEAAAGITSLLKALLVFQKNMIPKHIGIKTEINPIIPKDLERRHVGLAMENTPWPRPAGKKRLAVVNSFGAHGGNTTVLLEDAPERVKVSTQDDRTTHPVVISAKSKKSLQANIEKLLSWLDQNPDANLGDLSYTLCARRMHHSMRFGAAASGIAALQKTLRSWLDNPKASAELRAIPNDTPSVVLTFTGQGAYYSGMGRELLAEFSYFRTEVFQLDQIAQRLGFPSVVPVIDGSIDDGPASPVLTQLSVTVLEIALARFWSHLGIRISAVIGHSLGEYAAFAVAGVISATEALYLVGRRAQLTEERCTQGSHSMLSVRASEDDIEELIAGSPDTAELAYEVCCRNTPQDTVIGGTQESIDSIRQALEKNTIKCTQLDVPFAFHTAQMDPILDSLETLATPITFKAPSIPVLSPLLGSVVFDRKSIHAQYLRRATRETVDFVAAIEAAQDFGLVDAKTIWIDVGPHPICASLVRGIDSSASVISSCRRNEDNLATMSKSLVTLHLAGLTPCWAEYFRPREQEYSLLKLPTYSWNETDYWIPYIGTWTLDKALLKYGEKKAPLSLSMSRPSALRTSLVHQITTETVEATTATLHVLSDMQHPDFLEALHGHRMNNCGVATSSIWSDMAFTVGEYLYRRLVPQAKDVHMNLSDLEVLHAQVALEKKGSVQPLVLKAHLNLSTSSMSLAWFNASAETGECAAESFATCVVRFEDPAAWTREWDRLSHLVLGRIEALEQRAVEGKASKLSKPLAYTLFKNVVDYADRYRGMDQVVLYEHEAVAEVTLVAERHGTWHTPPHWIDSVSHLAGLVMNGSNASNTRDYFYVTPGCSSFRLLNPLKAGGKYRSYVRMFPLPEEANMYAGDVYILEGEQIVGMVGHIRFRRVPRLLMDRFFSPAAASHTEKQLQETAPSATNVKKSTPPPAEAPISVPVAPGNPVAIPLPTASKSQVATPPLTPPSQEDSPGESAVITPATSDRGDSTDAGVVGQCLKVMARETGLEVDALTPDASFVQLGIDSLMSLVLSEKFRAELGIEIKSSLFLECPTIGEMTAWLEEYC
Protein: Protein FAM161A (Q3B820)
Organism: Homo sapiens (Human)
Function: Involved in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22940612}. Cell projection, cilium {ECO:0000269|PubMed:22940612}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:32110738, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. Note=Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium. Localizes to the inner scaffold in the central region of centrioles. {ECO:0000269|PubMed:32110738, ECO:0000269|PubMed:37934472}.
Interaction partners:
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit epsilon
- POC1 centriolar protein homolog B
- Centrosomal protein POC5
- Peroxisomal biogenesis factor 19
- T-complex protein 1 subunit eta
- Lebercilin
- Cone-rod homeobox protein
- 10 kDa heat shock protein, mitochondrial
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Sequence:
MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRELEEREEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q584R1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine/threonine-protein kinase, putative
- Protein kinase, putative
Sequence:
MPRSGDAKSSGSEVACRTFDPCQLNLSSATPVGSGAISHVVRTTLQGAANTPIAVKILSKIQLLQQKKVQSAMNEKRALLDLAPHPFIARLYGTAQSEDELYFVMEHLPHGDLLEHIRTRYSRHSCRRHSEDVANTPSDRNGLQTSSSSTPCLDFHDIQLITAQLVVGLAHVFAKGFVLRDLKPENIVFDEKYRACLIDFDTVDVEGRTALPISNKGVAVRSKRSSGEGKDGAKKRLTISSIQTMRRNTANFCGTAQYVSPEMVGECRWSYSSDLWALGTVVYEMLYGKHMFSGDNAFKVMKAVVKGVSPENVPFPRVDIGPEFDAFERTKDFIVRLCHTDPTQRLGVNPITGMFDLDVLRQHDIFGDFCWDVLDEHVQQYRPVDISANPNECAAPASFRGPLHPQMLSDHTASLESHYHAVPVHNPEYAEYVYTATADVNPFERWACGVVEKDANYNVENEAVTRGLEKESVPKLSAENSECDGSDDDDDDISVIDDVGVQYFNNVHEDFMK
Protein: T. brucei spp.-specific protein (Q57Z74)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGPKKQLRRRGDKEPTNDGTEMLGEENLSAVSELRYEEEEGREGAERQRSSRGDAQISPQISRKRTRSATAERSPRNVDETEAEQDLGEDAVGPGARRSSMEIRHSNTNWSIRERSTNLRNDQEGFFHDLNTMQPLRVRLGVCPPFGCSRANTTPMLLMPRKFFVLPEDKGGSDVVGWAGAFTSVSLDLPEQGIYNKASASLTLMLPP
Protein: Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) (Q9VIM5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit
- RE12101p
- LD35927p
- WHAMM and JMY related, isoform B
Sequence:
MILLEINNRIIEETLLVKYRNAQAGLKPESIDIRIADFDGVLYHISNVNGDKTKVRISISLKFYKQLQEHGADELLKREYGSLLTDTEEGYNVSVLINLEEIPEDCEQIAKRIGLLKRNCFASVFEKYFDYQEQGEEGQKRAVINYRNDETLYVEAKPDRVTVVFSTIFRDEDDVIIGKVFMQELREGRRASHTAPQVLFSHREPPLELANTDARVGDNIGYVTFVLFPRHTNKETRDNTINLIHMFRDYLHYHIKCSKAYIHSRMRAKTSDFLKVLNRARPEPKNTEKKTITGRTFKRID