wanglab/gogpt-training-data huggingface dataset:
Protein: AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) (P35585)
Organism: Mus musculus (Mouse)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Interaction partners:
- AP-1 complex subunit gamma-1
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit beta-1
- AP-1 complex subunit sigma-3
- AP-1 complex subunit sigma-2
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit mu-2
- AP-2 complex subunit beta
- AP-4 complex subunit beta-1
- AP-2 complex subunit alpha-1
Sequence:
MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIEAVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMVKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSVKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTQ
Protein: Uncharacterized protein YML037C (Q03703)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MDENKIIDQLFSKEYTPQDDSEQAKNGDVSLYGLLDEVANGRRLMNCLFHSPMQMGNKLSTDKLDGKCRQIQRDWIDEEKTITMNSGALQLDGPVLFSWSHNVAPTSHQETINTTFKQGSPSRGSNKPKITTTSQLFDRASAEIDKCIKPNSKSWMVEERFERNEAHTADGKKPSTWANSDFKVDPLQKFVVKELPKEKKKSDGDKTKKNKSKRKSFFGFWGHSGSKSGSKKKSEKPIEAKNEIQDEVSQKSGLSPDDDTTFSDKNTIQSKQESMSDQQAEPKVHEPAVTNTGCSEHDDGDGFEQVPAQSSYHPSSEPSIASTPSLTLDSFIPLQPKKKI
Protein: Histone PARylation factor 1-like (Q9VNI3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cofactor for serine ADP-ribosylation that confers serine specificity on Parp. Switches the amino acid specificity of Parp from aspartate or glutamate to serine residues. Acts by completing the active site of Parp: forms a composite active site composed of residues from HPF1/CG1218 and Parp.
Subcellular location: Chromosome {ECO:0000250|UniProtKB:Q9NWY4}. Nucleus {ECO:0000250|UniProtKB:Q9NWY4}.
Interaction partners:
- Poly [ADP-ribose] polymerase
- Uncharacterized protein
- AT31036p
- Uncharacterized protein, isoform A
Sequence:
MPKEDCKYWDKCYQQNPAHLSKYNHPKKQQEHEVDGAEGKKVAPKRSASSQSGEQKKEEQTEPVNKDKSNTSASSTEMVNKDTAKGSYEAETEELHKEAMSNISGKNYMEILEKRIRLSVQKEYDNLCESNEFIRHKFLVEMPPDFYEFWKFVGSLKIDPAKPKDAGLEHLDKVFQLQLVGPFEFLAGKFHGAKLGEPGDYLRHWRFYYDPPEFQTIFVRRGTGIHYGYWRDVPQDKENLLIARNDSAKGCQFQFVAGNAFDAFLYYLEHDFAATPFSCGQLAGTKKAVAKYLSDNSLELAQLDRLQRERNKRVVAKTFHRAGIVVPFDQKTEVGYRPLAVSDSELKKMLAMLERKDVDNGAAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSLLVPAYSMLSRPQFIAIAKAHMEQRSREDNLSIFDVLK
Protein: Fumarate hydratase, mitochondrial (EC 4.2.1.2) (A0A0S2Z4C3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
Protein: MORN repeat-containing protein (Q57WF5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MALGSGIGLVPMWSSCPSVNPPTFPKGGIEILRQSLEAQEEVERTFREREAGHIECLNFKKSLRHLLRKQNERREELQLVEQRASERTQALLDELLIVVRERLKAMSPEGYQSITFDNGDMYEGNWKSCRMHGTGVMRRVADNDIYEGEWFFGVRNGNGMCCSPNFGTLYSGKWLAGKWHGRGELAEPEGLYIGDFVDGQIRGYGEYLYREGYAYKGDWVNGVYEGSGTFFYTNGARYEGQWRNGYEHGRGTMTYYNGDVYTGDWCNGRKHGTGTYTSKLLQYEGGWSSGAVHGIGKCTYADGSMYKGSWCRGLYDGDGEFVSQDKKCSYKGEFRGGKRCGRGVYQCGEVEYSGDWLDDRRHGVGEIKTRDGRVFRGTWSHDEPHCEVVPGCNLEGTSLSYCGGRGAPIAPEEPDPVLNMRLGLPDEVIDCMADAPT
Protein: Putative DEAD-box RNA helicase HEL64 (EC 3.6.4.13) (Q26696)
Organism: Trypanosoma brucei brucei
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEETYSPFTGRQGQYNQGYNGGGRRDSRGGMGERIKPVDWGNVSLVPGNWKVLDGKAIKKAGEIKTSTPEAGQLSEEEATKWREEHVITIFGDDCPPPMSSFDHLCGIVPPYLLKKLTAQNFTAPTPVQAQSWPVLLSGRDLVGVAKTGSGKTLGFMVPALAHIAVQEPLRSGDGPMVVVLAPTRELAQQIEEETKKVIPGDVYCGCVYGGAPKGPQLGLLRRGVHILVATPGRLIDFLDIKRINLHRVTYLVLDEADRMLDMGFEPQVRKICGQIRPDRQTVMFSATWPREIQRLAAEFQKQWIRISVGSTELQANKDVTQRFILTQEFAKQDELRKLMQEHREERVLVFCKMKRTADELERQLRRWGYDAMAIHGDKEQRQREFILARFRKDPRLCLVATDVAARGLDIKQLETVINYDFPMQIDDYVHRIGRTGRAGGEGRCVYLITKKEAQITPSVLKELIGILERAQQEIPDWMIEWNAQQPRYQVKRNRGMNGFGRHQSAPFLRNGHRPSFSANGNYSAHGNGTFGLGKHNDDAVPFSSSAIQYKRFDSDDEAEPSRKKYAR
Protein: WASP-related protein (Q54QH4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Serine/threonine-protein kinase pakG
- Serine/threonine-protein kinase pakF
- Serine/threonine-protein kinase pakH
Sequence:
MTNQSNCQNCDCKTFDPNPFKPLYCSICLHNHKVKNANVSVNATSTSTSAAPPKSSSTNNKGATISGSPSTSSSSLNQQQKSKPLPPKTPSKSPSSPNLTSSSPSSSSSGGGGGSGGSTAVKKRPDAQNFSKQSSSSSSSSSSSSSSSPSATSPKTSSGSSSSSKSSGSSFMSKIGSFKDAVTDKVNTLKESTFSSSSSSSSEPEVKGYEISGPTDYKHNTHIGITENGGISTRNIPEEWKQTFQKVDQALKQNGKRGITKKEATFILNAVLSGQTPSPNVSLRTTPVATSANAPALPPKPNANNKPLPSAPKTIPSASPSISSTTTTTTSTSSYNSSVKSTPSSSVSSSVSSYSSSYNNNNNNNNNNNNNNYNKNTTSSSYNNGEIEKLRDKIKQLENKLANEEKEHNLLLTKYKTLESKYTGGETNQNQAVNEAKTAKTKLEQLEREHSSLLNKIKVLETNNQLVQNENKNQENELSNLKKSILDSKKNMDADKGPLIEKISTLESKLKDSEFEKRSIQSKDQELEKKLKELTNQSKESEQQSFEYQVKIKELSSQLDSLKEALSNNKDLSSKIQEISNQFQQKEKELKESYEKQYNQRLNNQKLEIDQLSSTLSKEQQKSNKFEMELTSKQRDFESTQKQRDEFKLQFSKSQSQSDQLQSTIDQLENQLKQIKLSQAQSQNILDSNNKQQSDQLKSLSDSNNKLIKKNEELESIIDKSRKDSIDIKGNYEQKIVELESKIKISQNESNNQHDQKLFDLQNKFKSEKDDLLLKIKQLQDQLSTTTTTTTKHQSHSSSSSAVPAATTTSTSTPSSPPPPPPVAPPPPPSSFKQPSSDTSRNNLLESIRQPKELKKVTEADMTHNNQQEDDGSMVNILVRALIDRRQNMNEDDYDDEDEEVAWDD
Protein: Initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) (Outer chain elongation protein 1) (Q5A4E3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synthesis or phagocytosis by neutrophils.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P31755}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P31755}. Golgi apparatus membrane {ECO:0000269|PubMed:16855023}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P31755}. Note=Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum. {ECO:0000250|UniProtKB:P31755}.
Interaction partners:
- Mannan polymerase complex subunit MNN9
- Van1p
- Alpha-1,6-mannosyltransferase
- Putative alpha-1,3-mannosyltransferase MNN1
- Anp1p
- Alpha-1,6-mannosyltransferase
- Glycolipid 2-alpha-mannosyltransferase 1
- Mnn4p
- Mannan endo-1,6-alpha-mannosidase DCW1
Sequence:
MLQLREPQMVHKHLKLAVLGIVVIFTTYFIISSLSSPTSTHKTEYNSPKLQLAKELELNSNWKELGLNFQPNKKYSLPDESTLRQQLSYQFPYDESKPFPKNIWQTWKVGIDEKSFPKRYLKYQQTWEDKNPDYKHYVVPDKQCDLLIEQLYSQVPDVAKAYRIMPKSILKADFFRYLILFARGGVYTDIDTVGLKPVDEWISNSEMILEKKNRSGLVVGIEADPDRPDWADWYARRIQFCQWTIQSKRGHPMLRELIAKITDITLTRHKKGQLKKVLGKNEGGDIMNWTGPGIFTDTVFEYMNNILQSPEVFKNKKKWATIIDWKLFTGMEQPIAIDDVLVLPITSFSPDVNQMGAKDSHDPMAYAKHMFSGSWKDDGMPEMEQ
Protein: RUN domain-containing protein (K8ESM7)
Organism: Caenorhabditis elegans
Subcellular location: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
Interaction partners:
- Serpentine Receptor, class E
- G-protein coupled receptors family 1 profile domain-containing protein
- Uncharacterized protein
- Coelomocyte uptake defective protein 15
- ADP-ribosylation factor-like protein 8B
Sequence:
MFKRLNKTTQMASAPPQLTPAQKLKQEKIRADLQKELDNVVKAAIASPHSKRENVPSEITQNLCNSIEAIFIHGLRDPFFLKGTRYAKYPEPNFWPFVSKFSHRSITSQIACLGQIRSEIGKSRAWIRIVLNENALGQYLDLLAAEATAIQQFYSDDAFLRLLSDGDQSERIRGLLKPLSSLPISAATNSSFLNTWTPTPLILAGLMDGQPLKVGTLKARPNPKPAHLTEEIAIPAIDALVPEEDHDIGSPSYLEKRRRRALSRPIRKSENDDHSDCSSVYSHPSMLDSGEMSYQHAVLGGLKGSSSSSMRRVASNQKIQLPQSPLFSSTPVDSTILDQVKIGKANSRLDFVQTVSDVAPDAPPGYQPLVISRRIRRPSKQKSNSRSSSESASRDSRRVTEAISTRDSRANSDLPSTIFGTVPNDVAFSPDDELLQLQSKPISTTIDSGIAEMTSSSAAGTRTASEVEPEGELQVERSVSFLEALHELAGARGARDGAEEEAIPPPRSLSLTDDFLGKNEEKSEHEDEDREIFDVSMDPVEGTSITILAPNPPTGELNRSQPMSIPGGRRQLIHRPQKTDTILGTSLRDELLEALPSTHNDTFENGTPIYVQSPGLMGNSLAAIGARHQMWESTSDRLSSSSDSCGGPVVSFGQALRSAMETRDDPESLGTSSQDLADVDEQDVADSSRKSSVSAETAEKLCTIPREKGLDAQDFRCAMCRKTIGGSTFSKFETCAIDSKYYCTECMKSGGKVSIPARVVMDWDWRERAVSDRGRAWYEANQEKALINIKTTNSRLYAHAPALEETRKLREKLQLVSMYLFTCRESVSEDFRRRLWPKEYLRSEIDVYSFADLIDVKSGALQRRLNSLLKHSINHVMTCTLCKQKGFCCELCTVNEVIYPFNTESTHRCLVCFSAFHVECWRTSGDCPKCVRRQNFETRRAQVDDPHNTLLVLQP
Protein: peptidyl-tRNA hydrolase (EC 3.1.1.29) (Q5XI86)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLSKLLTMEYLVHPGTLSLAAGVACGMCLGWGLRSHLGIFPQNSTSETNRDTEMGTEASILGESGEYKMILVVRTDLKMGKGKVAAQCSHAAVSAYKQIQRRNPQVLKEWEYCGQPKVVVKAPDEDSLIQLLTHAKALGLTVSLIQDAGRTQIEPGSRTVLGIGPGPVELIDEVTGHLKLY
Protein: Cortactin-binding protein-2 N-terminal domain-containing protein (H2KZD4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPNLLDDSFDPTFQSTSKKLVLPSIRKVQPEYDNLPEEQGVNDFSSDELMKLLSFMEGEVQAREDVIDHLKRERTKILLSEAKYGKLNMNDPFAALRRDSAITGEQIDEEKIVQMYESQVDQLDKMMAVQKQSQRNAAVLLVALEKKQYKLVKKLEADREAKIRYAKQGDDLVAHLEKERNQLQQQIEFHIEEKRKAEIAKDKMEMTLGNEKKRHESIVLYLIQERKQMLLKMHELRVKAEQIMLQNQNDPTKPGPSSALSERELIEELKKEVTFLRAERESLTKTQKMVKTENLSLRETVRGQEADLQMLRRNLTLTGAKMSIDKPGNVLPQLPPDTGSLIMANRGAKPAVNRQQPAPPPVARLPNSATFPTEKSRLPRAPPPAVTTPVPRMSIGSLPASSSNVPRTMSSPVKKTPVMGVSSTAVRRPQSAATTTMPTTSVITNTSAVMPLSPDLEQLEAAIQSMNAGPSSNVASERKLSGTVKRNGILAKAFGSSK
Protein: Gene 23 protein (ORF 23) (ORF23) (Q76TK5)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MLRVPDVKASLVEGAARLSTGERVFHVLTSPAVAAMVGVSNPEVPMPLLFEKFGTPDSSTLPLYAARHPELSLLRIMLSPHPYALRSHLCVGEETASLGVYLHSKPVVRGHEFEDTQILPECRLAITSDQSYTNFKIIDLPAGCRRVPIHAANKRVVIDEAANRIKVFDPESPLPRHPITPRAGQTRSILKHNIAQVCERDIVSLNTDNEAASMFYMIGLRRPRLGESPVCDFNTVTIMERANNSITFLPKLKLNRLQHLFLKHVLLRSMGLENIVSCFSSLYGAELAPAKTHEREFFGALLERLKRRVEDAVFCLNTIEDFPFREPIRQPPDCSKVLIEAMEKYFMMCSPKDRQSAAWLGAGVVELICDGNPLSEVLGFLAKYMPIQKECTGNLLKIYALLTV
Protein: Small ribosomal subunit protein uS4 (40S ribosomal protein S9) (P46781)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
Interaction partners:
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL22
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS6
- Ubiquitin-ribosomal protein eL40 fusion protein
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL24
Sequence:
MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED
Protein: Exonuclease V (Exo V) (hExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog) (Q9H790)
Organism: Homo sapiens (Human)
Function: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.
Interaction partners:
Sequence:
MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISLQNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASIHLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGVIDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQETATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYADICEWRKGSGVLSSTLAPQVKKAK
Protein: Ribosome-recycling factor, chloroplastic (Ribosome-releasing factor, chloroplastic) (Q6NQM0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Elongation factor Ts, mitochondrial
- Polyprotein of EF-Ts, chloroplastic
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS2c
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL20c
- Large ribosomal subunit protein bL31c
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS9c
Sequence:
MMAMFVRRALSSRNAIGFLRRSSVVVQSRDFSFISSPNLMMMGGRDLQFDLSMPDFLRDSRRGFAKGKKSKDDSGTGMVDAAPDIGPTVKAAASSQMEAAIDALSRDLTKLRTGRAAPGMLDHIVVETGGVKMPLNHLALVSVLDPKTLSVNPYDPDTVKELEKAIVASPLGLNPKLDGQRLVASIPALTKEHIQAMCKIVTKSSEVVKQSIRRARQKALDTIKKAGSSLPKDEVKRLEKEVDELTKKFVKSAEDMCKSKEKEITEA
Protein: FAD/NAD(P)-binding domain-containing protein (Q2UA33)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Glutathione reductase
Sequence:
MAPKSLFYTLFSSLTVALAASVPQTDYEVIVVGGGPAGLTALSGLSRVRRKTALFDSHEYRNAATRNMHDVIGNDGTVPSEFRGLAREQISRYDTATFIDKRVNTIETVSDEATNTSYFRAQDADGKAYTARKVVLGTGLVDILPDVPGLQEAWGKGVYWCPWCDGYEHRDQPFGILGALPDVVGSVLEVYTLNTDIIAFVNGTQTPDQEAELAKKYPNWEAQLEAYNVRLENETIASFERIQDGSWVKDRNGTRQIDIFRVHFTNGSSVDRNAFITNYPSEQRSDLPKQLGLAMLGNKIDATTNPGMRTSLPGVWAIGDCNSDNSTNVPHAMFSGKKAAVFAHVEMAKEESNTAIDKRDDFVKEVEKRMGNDMEKIYNRSRGL
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) (Q99JT1)
Organism: Mus musculus (Mouse)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03147}.
Interaction partners:
- Glutamyl-tRNA
- Aspartate--tRNA ligase, mitochondrial
- Glutamyl-tRNA
- Asparagine--tRNA ligase, cytoplasmic
- Asparaginyl-tRNA synthetase
- Fatty-acid amide hydrolase 1
- Glutamine--tRNA ligase
- Aspartate--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
Sequence:
MAAPMLRLGFPGRRWALTWLDGGSRHRSGSQTGPTSNWARRQSSVAQPSLHTAQKPRKGEHKWAAVVGLEIHAQISSNSKLFSGAQVCFAAPPNSLVSYFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYSDLPAGYQITQQRLPIAANGHLTYCIYLGKKPSQVTTKTVRIKQIQLEQDSGKSLHDDLRSQTLIDLNRAGIGLLEVVLEPDLCCGEEAALAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSLRFLAKAIDYEIQRQITELENGGEILNETRSFDYKLGCTMPMRDKEGKQDYRFMPEPNLPPLVLYDDTSLPRGADSQQVINIDQLRDMLPELPSATRERLVQQYGMLPEHSFALLNEVGLLEFFQNVIKETRTEPKKVTNWVLNTFLCYLKQQNLAVSESPVTPSALAELLNLLDRKAISSSAAKQVFEELWKGEGKTAAQIVSEQQLELMQDQEALEKLCQTTIDGHPQVVMDVKKRNPKAINKLIGLVRKASHSRADPALIKKILERKLSL
Protein: Cathepsin L-like cysteine proteinase (Q9BJM3)
Organism: Onchocerca volvulus
Interaction partners:
Sequence:
MLRIIVLLIVFAFLVDFTVTLNAQVQQLREVLGTFDQDYKRGNMTRLTTDFKKAVKKYGDGKESQKSTVLQSFLKKMEDNGELRAMEKLETEWNDYVMALGKHYDSNESNLRMAIFESNELMTEATNRKYEQGLISYTNGLNHLADLTDKKFKMMNGLRFPNETHLRTRRQTRHTVGQKYTYDPNEKLPVSVDWRKKGMVTPVKNQGVCGSCYAFAAIGALEAYNKKKTGKLVDLSIQNAVDCTWTLGNYGCRGGYMNPIFYYATKFGLAMESEISVLGTEQKCKWQEENAYATDKGYAAIQRGDELGLMHAVAKHGPVVVGINGSKRPFKFYKSGVYSNRDCGDLNHAVLLVGYGKHKTYGEYWIIKNSWGTDWGKKGYAYMARNKGNMCHIATLASIPI
Protein: Leucine-rich repeat protein (LRRP) (Q583Y7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPLCVPLLQNVLAWYGDELSISLALLSTSPSVRFFCERHAEPPLRILAGTWTVQCRTDGPRFITHNVGIKVADALGADVFSSMAWWCNRIVTSSSGRGREPVQLHLNLNGARCSVEQVLQGALAFRTLVELSLRRVSIKDVNVLGKMPSLQKLDLVEASVADSGIVGLGDSNSLVSINLWGCEDIADVSVLGKIPTLRELVVAETKVTDCGTAGLVDCVNLRELNMEACPSITCVGAVSELPVLQRLLLVTTAVTSAGIASLGNSRSLVEIDLWGCRGVDSVNTLGKIPTLRRLDLFGTSVTNEGIIELGCSQSLEEVDLTFCEAISDVGTLVAVPTLQRLILLHTSVEEGACRQFSKRVSIAI
Protein: ATP-dependent DNA helicase RRM3 (EC 3.6.4.12) (Regulation of Ty1 transposition protein 104) (rDNA recombination mutation protein 3) (P38766)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Needed for normal fork progression through over 1000 discrete sites scattered throughout the genome, like rDNA, tRNA genes, centromeres, active replication origins, or transcriptional silencers. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in regulation of Ty1 transposition and protects the genome from instability at nascent sites of retrotransposition. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Also plays a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
Subcellular location: Nucleus. Chromosome, telomere.
Interaction partners:
- Origin recognition complex subunit 5
- ATP-dependent helicase SGS1
- ATP-dependent DNA helicase SRS2
- Topoisomerase 1-associated factor 1
- DNA repair and recombination protein RAD52
- Mediator of replication checkpoint protein 1
- DNA repair protein RAD51
- DNA replication fork-blocking protein FOB1
- Serine/threonine-protein kinase MEC1
- Chromosome segregation in meiosis protein 3
Sequence:
MFRSHASGNKKQWSKRSSNGSTPAASASGSHAYRQQTLSSFFMGCGKKSAAASKNSTTIIDLESGDEGNRNITAPPRPRLIRNNSSSLFSQSQGSFGDDDPDAEFKKLVDVPRLNSYKKSSRSLSMTSSLHKTASASTTQKTYHFDEDETLREVTSVKSNSRQLSFTSTINIEDSSMKLSTDSERPAKRSKPSMEFQGLKLTVPKKIKPLLRKTVSNMDSMNHRSASSPVVLTMEQERVVNLIVKKRTNVFYTGSAGTGKSVILQTIIRQLSSLYGKESIAITASTGLAAVTIGGSTLHKWSGIGIGNKTIDQLVKKIQSQKDLLAAWRYTKVLIIDEISMVDGNLLDKLEQIARRIRKNDDPFGGIQLVLTGDFFQLPPVAKKDEHNVVKFCFESEMWKRCIQKTILLTKVFRQQDNKLIDILNAIRYGELTVDIAKTIRNLNRDIDYADGIAPTELYATRREVELSNVKKLQSLPGDLYEFKAVDNAPERYQAILDSSLMVEKVVALKEDAQVMMLKNKPDVELVNGSLGKVLFFVTESLVVKMKEIYKIVDDEVVMDMRLVSRVIGNPLLKESKEFRQDLNARPLARLERLKILINYAVKISPHKEKFPYVRWTVGKNKYIHELMVPERFPIDIPRENVGLERTQIPLMLCWALSIHKAQGQTIQRLKVDLRRIFEAGQVYVALSRAVTMDTLQVLNFDPGKIRTNERVKDFYKRLETLK
Protein: Probable choline transporter (Q9HTR3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- HTH-type transcriptional regulator BetI
- EamA domain-containing protein
- Major facilitator superfamily
- Probable ATP-binding protein YheS
- Oxygen-dependent choline dehydrogenase
- NAD/NADP-dependent betaine aldehyde dehydrogenase
- Glycoside hydrolase family 19 protein
- Probable GMC-type oxidoreductase
- Choline sulfatase
Sequence:
METPTTPRSTLNPPVFYTSAALILALVLFTVLLQEEAQSLFNHVQQWIITNASWFYVLAVALILISVVFLAVSRYGDIKLGPDHSRPDYRNTTWFAMLFSAGMGIGLMFFGVAEPVMHFTTPPVGEPNTVQAAKEAMKLTFFHWGLHAWAIYAIVALILAFFSYRHGLPLTLRSALYPLIGERIYGPIGHAVDIFAIIGTVFGVATSLGYGVLQINSGLHHLFGWPVNQTVQIALIAATCGLATLSVASGLDRGIRILSELNLSLAVILLLFVLVLGPTVFLLQTYVQNTGAYLSDIVNKTFNLYAYEPTDWIGGWTLLYWGWWLSWSPFVGLFIARISRGRTIREFVCGVLFVPAGFTLLWMTVFGDTAIHMVLQEGFTQLAEVVNQDSSVALFAFLEHFPLGSVISLVAVLMVVVFFVTSADSGALVVDMLASSGKDHSPLWQRIFWSVLMGVVAIALLLADGLKALQTATIASALPFSIVLLASIWGLFKALHLDATKRGIRYQALTFSRPTTRSGASEGDGWQRRLRNIAMFPRRSHVNRFITDVARPACEDVAAELRKQGYEVQVQDGEDGRVRLEVSHGGEVDFIYEVRPRAFTTPSFVMRDTEDSSESRKYFRAEVHLQEGGQDYDIMGWSRDGVIGDILDQYERHMHFLHVVR
Protein: MRG domain-containing protein (H1UBJ1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNCKNCNKKTNCCCKKCTLEKLKIYSRRENITQRYEEKERLQAEILAFIDPTESLKEQITIKEDRLIKLHIAVENAKMRIAMKQSEVNKLDTTPHSKPSQFDAVFTSQSNFISRADIKKKEKSERLTKLEEEVAKKRLKYCIHACRIFPVQVYDVNVESVTVKSKNSKNWAVVNDSELQKGLRIAIRNSYINDKLRAKLANQLSNGTISLPLDLHPPFAAFTNTLQLVHLLSVIFNFRPPETLSHHDLCIRERWTKESLNRDWSTLCDAVIYLCIFIGMSHTKLKYTDPHHNLIALASFVVNDYNNINRIGSRPMCDLSEVHALIEAQRPEDCQKKDELDESWTFVD
Protein: Protein bfr2 (Q9US05)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C57A7.06
- RNA cytidine acetyltransferase
- Probable nucleolar complex protein 14
- Ribosome biogenesis protein bms1
- Ribosome biogenesis protein enp2 homolog
- Uncharacterized protein C18B11.06
- Pre-rRNA-processing protein pno1
- Probable U3 small nucleolar RNA-associated protein 7
- Protein sof1
- Uncharacterized WD repeat-containing protein C2E1P5.05
Sequence:
MGKVSLKDELAGMLNPQPQERDPEALEDAFSDREDSSEEENDTLGREHYVDVSESKLRSKQAPQLDPKFKGRKTSRQELLNSGSLNSQSSSPSEEEDSEEDENDAVSEDHENFSSSEASSISEENEDDDQSSAIPEKDMDRLKKIINGEKKLSDQIRTSALEDMKKGLALKEQMRFYDNVLDTRIRLQKGCSQLLSSSNQLQGDKVEARDGLVSFIQHTLQLRKNLLIDSGVEILDSRSKRKENPVSLEEIALEMNNLDDSLNEWKNDTLTKWHNRVQAVQGISQSNKFKALNQSIVQQIENSMINKKDLVERTRIDYSDPNNKTFNPEIYNDTDFYQSLLKDFINSRMADSTRDGTVRWMATKKQKQKKENVDTKASKGRKIRYHVHDKLQNFMAPIEVTVWPDEQTEDLFSSLLGQQLDLSETANDTNTSNFVEKDDELISSNDGFSLFG
Protein: Phosphorylase b kinase regulatory subunit (A0A8I5Y5Q0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}.
Interaction partners:
Sequence:
MARNAVFLSLLGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKSTMLTYQSPTTGLFPTKTCGGDQKSKVHESLYCAAGAWALALAYRRIDDDKGRTHELEHSAIKCMRGVLYCYMRQADKVQQFKQDPRPTTCLHSVFNVHTGDEVLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDFGVWERGSKYNNGSTELHSSSVGLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNTDAALLPCITYPAFALDDEALFSQTLDKVIRKLKGKYGFKRFLRDGYRTPLEDPNRRYYKPAEIKLFDGIECEFPIFFLYLMIDGVFRGNLEQVKEYQDLLTPLLHQTTEGYPVVPKYYYVPADFVEYEKRNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLADELISPKDIDPVHRFVPLQNQRNVSMRFSNQGPLENDLVVHVALVAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQQELVKAYFHLGINEKLGLSGRPDRPIGCLGTSKIYRILGRTVVCYPIIFDLSDFYMSQDVLLLIDDIKNALQFIKQYWKMHGRPLFLVLIREDNIRGSRFNPILDMLAAFKKGIIGGVKVHVDRLQTLISGAVVEQLDFLRISDTEKLPEFKSFEELEFPKHSKVKRQSSTADAPELRQEPDITITEWKNKSTHEILQKLNDCGCLAGQTILLGILLKREGPNFITMEGTVSDHIERVYRRAGSKKLWLAVRYGAAFTQKFSSSIAPHITTFLVHGKQVTLGAFGHEEEVISNPLSPRVIKNIIYYKCNTHDEREAVIQQELVIHIGWIISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPAVDLYQLSPSEVKQLLLDILQPQQSGRCWLNRRQIDGSLNRTPPGFYDRVWQILERTPNGIVVAGKHLPQQPTLSDMTMYEMNFSLLVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEFQDKVDLDKLVKEAFHEFQKDESRLKEIEKQDGMTSFYNTPPLGQRGTCSYLTKVVMNSLLEGEVKPTNEDSCLVS