wanglab/gogpt-training-data huggingface dataset:
Protein: Inactive protein tyrosine kinase pTKL (PfpTKL) (Pseudo-tyrosine kinase-like protein) (Q8IIT5)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Parasitophorous vacuole {ECO:0000250|UniProtKB:A0A509AIU5}. Host cell membrane {ECO:0000250|UniProtKB:A0A509AIU5}; Peripheral membrane protein {ECO:0000250|UniProtKB:A0A509AIU5}. Host cytoplasm, host cytoskeleton {ECO:0000250|UniProtKB:A0A509AIU5}. Host cytoplasm {ECO:0000250|UniProtKB:A0A509AIU5}. Note=During the trophozoite stages, secreted into the parasitophorous vacuole and into the host erythrocyte cytoplasm. At the schizont stage, localizes to the parasitophorous vacuole but not to the host erythrocyte cytoplasm. {ECO:0000250|UniProtKB:A0A509AIU5}.
Interaction partners:
- Gametocyte-specific protein
- non-specific serine/threonine protein kinase
Sequence:
MGNTLDSNKPKNFVTYADYKYIGKLNNKNEHHGIGIILYNSGESFYGSFINGKKEGKGIYIDKNLTRYINTWVDNKVFGKVKVVPYNSNRVYYFYYKNYMIEKCIYFDNNINNKESHHKNNIYNNYDNNSYNNNSCDDEEKRKYPIGVTKFKEDLSNYIHSTHIMKKNNKLFNKNDNEYNIFSSSLSYSSDSENINLLDILKKKKNKKNKKNKKKKNKKTKNTQILSCTQHKMYEHNMNESNFTKKDNVNCEHTDKMNISLHEKNDKKNEKKNEKKNKKKKLFKYFSNNIENLIIENYQTWSLREVIQWLMLCNVPVKWLISFYKNNITGDKLKYININTIRNELGIIAYGHAIKILQLIKNLQVMAYNKKFNNLIQIEEYKNYIRQKENTNKNIKKGKNIKKEKKKKKEKNIKKEKKKKKKETKKFNNMDKKYIDLAIHKNVKNIQNDTFYNKHENIYNCKNQTNFIYQNDSEIKKIMNKKKVSFEYDNNEEKKKKNIIKFIKNNKSLQNSNGEYYLINHLSKGICSDSIFYKSSQSKSSSQLSSPLSSPLSSPSPSSSPSSSPSSSPSSSPSSSPSPSSSPSPSSSPSSSPSSSPSSPPSPLSYKDNFPISSSCSSLERLPSYEKKLLSSSQSNIEHIKNLPLDVLSNNNSSANIKIKKSKSKYNNDKKEQKKLPLILNKSSSEFSPSHSYTSKSYHYNIKPSLQSSSNNSSDSSYSISSTCSSSSSYVSSLYSNRSNDILNFYRNKIIKYCNNIYMNTKLAYSYMNGFIIPHEDLIFIHPIENYYMDNTNEKNNINNPYTKEKIMNHNFSFNTKNNTSFIDINTNIFSSNKQQNINNFGKYKKMKSRMFKGKYMGKEVAIKILVGKIKNFKKLHQILYNLYNLRHSNLVLIMGVSIHYPFVFIIYEYMKNKCLFSYLHCIKYKHVYISTFLQRYKTLLHITQQEKIKKTNNINNNNNINHNNINNNNINHNNINHNNINNNNINNNNINYNKDYNNKKKKEDEQHNIEHQDTFIDLPEKSNISSDDNNSTDISQIQKENFHFLNKKIEENKNIIYDDHTSTLSDHSIHNINKSYDNVYKNKMNIFHYQHNVLCGAYDNNDNNINDNDIYCNNIYDNNINDNHIYCNNINDNHIYCNNINDNHIYCNNIYDHHKNTSLNSKEQNTDHNIEQINECNKYASETKYNIKKSNLKNNIISHKNFQKCNQIQMNQPYTFPPYQKELSSYLKNEKIKRKRKVLFSYLKTHIHFNSQQINDQHNRLSVQKIMKIITDVTLACTYLEKEKMSPINLKPTNILLDESLNAKISDFGISKIENCLDMNIDYSYKISSNSVIKINKKEYEQKKAKKIKIVNKNNNDLLYLYDHNNNVYKYNTQYIDVTYNNSYPSIFYWTPPEILRGKKNKKFYSDIYAFGIILWEMLSNDIPYNYPFASHIMAVVGYANEELSFNNIPVSIQSLIKACVNRNKYKRPTFEHILKTISTLYQKANTKVEDALISFMDGT
Protein: GPCR-type G protein 2 (Q0WQG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Abscisic acid receptor. The GDP-bound form exhibits greater abscisic acid binding than the GTP-bound form. Required for seedling growth and fertility.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19135895}; Multi-pass membrane protein {ECO:0000269|PubMed:19135895}. Golgi apparatus membrane {ECO:0000269|PubMed:23001037}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23001037}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- LanC-like protein GCR2
- Guanine nucleotide-binding protein alpha-1 subunit
- G-protein coupled receptor 1
- Magnesium-chelatase subunit ChlH, chloroplastic
Sequence:
MGYGWGIFEGMLVIGSLCLLGSAGLWFLNRRLYKEYEEKRALVQIIFSVVFAFSCNLLQLVLFEIIPVLSREARMVNWKVDLFCLIVLLVFMLPYYHCYLMLRNTGVRRERAAVGALLFLTAFLYAFWRMGIHFPMPSDKGFFSMPQLVSRIGVIGVTLMAVLSGFGAVNLPYSYISLFIREIEESEIKSLERQLMQSMETCIAKKKKILLCQVEVERSLVSEEHQKGKSFFRRFVGTVVRSVQDDQKEQDIKLMEAEVEGLEELSKQLFLEIYELRQAKDAAAFSRTWKGHVQNFLGYACSIYCVYKMLKSLQSVVFKEAGTKDPVTMMISIFLQFFDIGVDAALLSQYISLLFIGMLIVISVRGFLTNLMKFFFAVSRVGSGSSSNVVLFLSEIMGMYFLSSILLIRKSLRNEYRGIITDVLGGDIQFDFYHRWFDAIFVASAFLSLLLLSAHYTSRQIDKHPID
Protein: Uncharacterized protein (Q587C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNSGTCIGGLQGSKDLLDAVRAAVVRGDLDALASLKGDFLVIKENIVKCVDGSGNTLVHLALGKNTTMLEFVVKELTGDVNAPNFQGRTPLHEAVRNNYVECCEALLDYGADVGAQSATLSTPFHTAAACGSVECMEVLLKRSDNPKNKVNELDRNKCSALHKSASDGDVRVSKWLVEHGAEVDQKDADDTTPLLMAVKMGKPDVAEYLIKQDANRDQADSHGNRPVHYCAIRCDYKILKILIDAGATVNVQNNDLNNPLHLAAIHQRPNSREWEDLIELLLDSGCDPAVENASRKKPADYVGRSFKKFFSNEVSVERRRLEKKKMQEEEEEFKTMLEMRNTWRANIVADLEKVKRRQKEELDRLHRETEERHRAEDDARMLLEEAIERKRYQEEQRKKRLEAAEKGASTMKK
Protein: P2X receptor B (P2XB) (Q553Y1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents are evoked by intracellular ATP and ATP analogs. Insensitive to the P2 receptor antagonists PPADS and suramin, and also copper ions. Inhibited by sodium ions. Permeable to chloride ions.
Subcellular location: Contractile vacuole membrane {ECO:0000269|PubMed:19833731}. Note=Ligand binding domain within the lumen of the vacuole.
Interaction partners:
Sequence:
MTIDWDSILSYNTIKVVRIRDRRLGILHLCFLIVIVLYVVVYSAIIKKGYVTTEEPVGSIRTSLLAPDELKSNQAYCKNNTEPYPYEKLDCVYYDEKLALFPIGDDVGFTASTRMRISDQTVNCSLMNPSCKFYTNTSMNVYLADIESFTVLIDHTMYAPSSQIQFNGDDLSGYVLDQNGNEIQLNESVNTIGVQGKPDILQLGKLLEFAGVDLDGPSLVNSSNSIRYDGCVLFVFIEYSNTFSYDLKKIKYVYSIKKVDDTAYDVPEVIILNNENSRLYYKRHAIRLIFIQTGVIGSFNFQSLLLTLVSGLGLLTVSTLIVDQLAIRFLPQRKSYSSLKFQTTESFRMKKKIVNDDGEDKLYHNIEAL
Protein: Anthranilate synthase component 1, pyocyanine specific (AS) (ASI) (EC 4.1.3.27) (Anthranilate synthase alpha subunit, pyocyanine specific) (P09785)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, a precursor for Pseudomonas quinolone signal (2-heptyl-3-hydroxy-4-quinolone; PQS) production which is required to induce the genes for the biosynthesis of the virulence factor pyocyanine (PCN), a characteristic blue-green phenazine pigment produced by P.aeruginosa. In the first step, the glutamine-binding beta subunit (PhnB) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (PhnA) to produce anthranilate (By similarity).
Interaction partners:
- Anthranilate synthase component 2, pyocyanine specific
- Anthranilate--CoA ligase
- Anthranilate synthase component 2
- Anthranilate phosphoribosyltransferase
- 2-aminobenzoylacetyl-CoA thioesterase
- anthranilate synthase
- Anthraniloyl-CoA anthraniloyltransferase
- 2-heptyl-4
- Chorismate synthase
- Indole-3-glycerol phosphate synthase
Sequence:
MGARRWLVSGVGYRLEESLEYRTLVPEALSIWRMAGANRMLFDCFDVDSKAARRSVAILSSCLRIECWGRDVVLRALNSNGRALLAPLSEDCPAQVTCLRDGDTLHWRFPQEESHADEWRRLHGLSSLEALRRVLGTLGDAEGPVLLGGLFSFDLAEQFEPLPAPAEPARHCPDYLFLVPELLLDIDHLARRTSLQAFVHDPAGHDRLAASLRQCADEFHGAVEEASESPVAGVRAGNYQVDLDDASFARQVERLQAHVRAGDVFQIVPSRSFSMPCADPWRAYRQLCLRNPSPYRFFLDAGDFCLFGASPESALKYDAESREVELYPIAGTRPRGRDARGAIDAELDNRLEAELRLDAKEIAEHMMLVDLARNDLARVCRSGTRQVRDMLKVDRYSHVMHLVSRVAGELHGELDALHAYRACLNMGTLVGAPKVRAMQLLRQYEDGYRGSYGGAIGILDSAGNLDTSIVIRSAEVREGIARVRAGAGVVLDSDPRLEAEETRNKALAVLTAVAAAERERGERDAHHAVG
Protein: Serine/threonine-protein kinase BSK11 (EC 2.7.11.1) (Brassinosteroid-signaling kinase 11) (F4I7Y4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1.
Subcellular location: Cell membrane {ECO:0000305|PubMed:12912986}; Lipid-anchor {ECO:0000305|PubMed:12912986}.
Interaction partners:
- Serine/threonine-protein phosphatase BSU1
- Protein BRASSINOSTEROID INSENSITIVE 1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Shaggy-related protein kinase iota
- Shaggy-related protein kinase eta
- Putative acyl-activating enzyme 19
- Protein BRASSINAZOLE-RESISTANT 1
- Auxin-responsive GH3 family protein
- Auxin-responsive GH3 family protein
Sequence:
MGCCQSSFLKPSSLHDKKITSDDLSGRRGKGAKRGNRHRHANINEGRGWHFSDVPDFSEFSASVLRDATNNFNKNAVVSVCSDQEPNLVYQGCIRSDKDKRLIAVKKFSKTTWPDPKQFATEARAIGSLRHVRLVNLIGYCCEGDERLLVSEYMPNESLTKHLFHWEKQTMEWAMRLRVALYVAEALEYCRQSGLKLYHDLNTCRVLFDENGSPRLSCFGWMKNSKDGKNFSTNLAYTPPEYLRSGTLIPESVVFSFGTFLLDLLSGKHIPPSHAVGTIQKQNLNVLMDSHLEGNYPEEDAAMVFDLASKCLHNNPNERPEIGDIISVITTLQQKLDVPSYTMLGISKLEKLEMEHPKSLIYDACHQMDLAALHQILEAMEYKEDEVTCELSFQQWAQQIKDVCNTRQQGDSAFRNKHFESAIDKYTQFIEIGIMISPTVYARRSMCYLFCDQPDAALRDAMQAQCVYSDWPTAFYLQAVALSKLNMVEDSATMLKEALILEDKRGS
Protein: Putative lipase atg15 (EC 3.1.1.3) (Autophagy-related protein 15) (O13934)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity).
Subcellular location: Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P25641}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P25641}. Prevacuolar compartment membrane {ECO:0000250|UniProtKB:P25641}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P25641}. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC). {ECO:0000250|UniProtKB:P25641}.
Interaction partners:
- Triacylglycerol lipase ptl1
- Ubiquitin-like modifier-activating enzyme atg7
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 8
- Probable cysteine protease atg4
- Autophagy-related protein 3
- Autophagy-related protein 2
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Triacylglycerol lipase ptl3
Sequence:
MSQLLFLRRFFFLFCFIIRISCTGVFESVIKSSENVPDKVNVKLQHVFHYGLNEDSISYYRLDVAKKSVYAESESKLPLKMKKGYSVHLKDQSRDALTDYRYKSMKGIYSEANSPADLWEQEAIVIPDITDKETIYSLGKMSYNAYQKIPFDGDWLDLGPDWNITPPEGFGWEEDGLRGHVFSNDDNSTIIIAMKGTSIFGIGRGTSQKDRVNDNLLFSCCCARVSWAWSTVCGCYKNTYTCSQTCLEDEVQDDSRYYSASLDIFYSVKELYPDAQIWLTGHSLGGATAALMGLSFGIPTVTFEAPGDRMAARRLHLPMPPGLPDEESLVWHFGHNADPIYLGKCTGPTSLCWAGGYAMESTCHTGQECLYDVVKDKGWHLSITHHRMQTVLNDVIDAYEKLPDCSHTPNCVDCYLWEFPDDDS
Protein: Cathepsin F (H0YD65)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD
Protein: Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) (Nogo66 receptor-1) (NgR1) (Q99PI8)
Organism: Mus musculus (Mouse)
Function: Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:22325200}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11201742}. Membrane raft {ECO:0000250|UniProtKB:Q9BZR6}. Cell projection, dendrite {ECO:0000269|PubMed:22325200}. Cell projection, axon {ECO:0000269|PubMed:22325200}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000269|PubMed:22325200}.
Interaction partners:
- Reticulon-4
- Myelin-associated glycoprotein
- Aminopeptidase N
- Tumor necrosis factor receptor superfamily member 16
- Tumor necrosis factor receptor superfamily member 19
- Oligodendrocyte-myelin glycoprotein
- Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
- NADH-ubiquinone oxidoreductase chain 1
- Adhesion G protein-coupled receptor B1
- Paired immunoglobulin-like receptor B
Sequence:
MKRASSGGSRLLAWVLWLQAWRVATPCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISHVPAASFQSCRNLTILWLHSNALARIDAAAFTGLTLLEQLDLSDNAQLHVVDPTTFHGLGHLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLMPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCNLPQRLADRDLKRLAASDLEGCAVASGPFRPIQTSQLTDEELLSLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPSSAEPPLTALRPGGSEPPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGASGTGDAEGSGALPALACSLAPLGLALVLWTVLGPC
Protein: Disco-interacting protein 2 homolog B (DIP2 homolog B) (Q3UH60)
Organism: Mus musculus (Mouse)
Function: Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin.
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:32153366}. Cell projection, axon {ECO:0000269|PubMed:32153366}. Perikaryon {ECO:0000269|PubMed:32153366}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- E3 SUMO-protein ligase RanBP2
Sequence:
MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYSPQTQETDSIGQKERNQTPAPTAAQTSAPSKYHRSRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENVSAPPDVTATTSSSSSSLRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVNSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEGIPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGSTQAKCPCLTGLDVTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEICLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSQCQALSQACNYSEGETVVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGLPQLCRTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVTSSGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMVVDVSKAACVLTTQTLMRLLKSREAAAAVDVKTWPAIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENNLFLWLATVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCIRTCVVVAEERPRVSLQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRVHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVVPINSRGEKQRMHLRDSFLADQLDPIYVAYNM
Protein: Calcineurin B subunit, putative (Q38CK1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein
- Serine/threonine specific protein phosphatases domain-containing protein
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- peptidylprolyl isomerase
- peptidylprolyl isomerase
Sequence:
MEVAAVASAPSAEEVSELRKHTRLSEAQITRLHERFTALDRCGKGLISPSDFQSIASVASNPLLSRVLTVVSSSGDGNISFVDFAKAFAVFLPQTDRQEKLRFTYMMYDIDGDGKISNSDLMEALKMMVGPNLTDVQLQQIVDKTFIEVDFNRDGFITFSDFEKLSLPISLDNAHVLQF
Protein: phospholipase A2 (EC 3.1.1.4) (Q9VT60)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFNVLQRLLGVDQPANKVVEIKSEALGTLQVLARDDAMLLFAPPFNSSNEKRAVYEIILQRPTSDSNTTSFSLYRSPVQQEAEERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYFNLVDYISNPKMLQCVDQADAATLMSPFQLAIKQGHMEMVKALLPLSKLEHLDINSNSVFHYAASTTKEIINLIIDKSTVNLNHLNSDGYTPLHVACLADKPENVKALLLAGANVNLNAKDIRKVYKTSAPTTVSSFLRTNVSKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLLAHDAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILYILHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPEAPESVEQREHIEHMLATTSRQMMGGFLNAAANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSAVSSPEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTSTGGILALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESILKDNLGEFNVMTDIKHPKIMVTGVMADRKPVDLHLFRNYTSASDILGIVTPINNRRIPPPQPSEQLVWRAARATGAAPSYFRAFGRFLDGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGHIPVTELKDIDVFRPESIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIAMDEKDDQKLINMLWHTKAYMHANRNKIIEMINFLK
Protein: Cysteine-rich protein 2 (F1QZB0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASKCPKCEKTVYFAEKVSSLGKDWHKFCLKCERCSKTLTAGGHAEHDGKPYCHKPCYAALFGPKGVNIGGAGSYVYEAPTNTSPPPNNGDSAPKAQEKWVPVSSRPPSKAGSITTFSGEANLCPRCSKKVYFAEKVTSLGKDWHRPCLRCERCSKTLAAGSHAEHDGQPYCHKPCYAVLFGPKGVNTGGVGSYIYDKEPNAEAQP
Protein: Pregnancy-associated plasma protein A, pappalysin 1b precursor (Pregnancy-associated plasma protein-A paralog b, Papp-ab, pappalysin 1b) (M1WXG8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKLLPICTWLLCLLLFLVCLGSECGTPRRIVRSKRDLVRIREARSTFPGACATRLPRGKRSLPGIDRRSPQLSQAGESSPGRRRAVYFTGRGDQLRLKPNAEVPRANFTLEMWIKPEGGQRSPAVIGGLYDKCFYASSDRGWLFGVKAVSDQANRDPRFFFSLKTDRAHKLTTITSNTAYTPNQWSHVAVTYNGLFMKLYVNGAQVAVSRDQSGEIFSPLTKKCKVLMIGGNALNHNYRGTMEHLSLWHQALTQREIIRSMRQGLAQLVDLSQLVIHENFENMSRRWLTVKDGSFPRLEHSDRSLASDLSDSALKPPACGQTVCDNVEVITNYYQLWSFRKPKTVRYRVINVYDDDGRFPTITEHQINLQHQHLNNAFRVYNITWERTVHNVYNSSLRNRLILANCDVSKVGDEECDPECNHTLTGFDAGFCKRQIARCPENKQGNGVCDPECNWDNFYYDHGDCCNPNITDVTKTCFNPASPLRAYMNVKELKEVLNLDGSTHLNIFFANSSDEDVAGVATWPWDKEALTHLGGIVLNPSFYGTFGHTHTMIHEIGHSLGLYHVFRGISEVESCNDACLETEPSLETGDLCADTNPTPKYKYCSDPEPGNDTCGRRHFTNTPFNNYMSYADDVCTDSFTLNQVARMHCYLDLIYQSWRPGSKPAPVPLPPRVTAQDQHSLTLEWFPALTGHYLDREVGSVCDKCTEVGVLLQYASNSSSPRPCAPSGHWSPREAEGPPDVEQACEASVSTWSPNAGLDSSSVGSASCPPQGCMLQLEFAYPLLPDSLSVWVTFFSLEDTGLPAIQDILLLTLSGNNVSLGPQYVFCDTLLTLKLDVKEEVYGVQFFTMEQHLEIDATLLTSKPDNPLCRSCHPLRYRLLRQPPFTHSPHGIIIQEPTLRYEDRDLNPDETYTYHVLTVSRRAESEPSPPLVHQLGSPYCGDGLIQKYLGEECDDMNFANGDGCSNQCKKEPLFNCVDQPSLCYFYDGDGVCEDFEREASVRDCGLYTPSGFLDQWATAVEVSNEEAIHCPAEVAAGYPAVTKSCQSKVFDLSHGVSQYAWFPCEESQQQSWTYWLKAYYAHPMVAAAVIIHLAADGTADMDQTQHNITVHLVDTKDQTHPLGDSRLSCRNNPLVIPVSHDLSVAFYRTKAIIVSFSSPLVAISGVGLRSFQYFDPITISGCQSNEIYNPMGQSCVHYSCDAIECQKPMVSNAEMRCNSPGYFNGARCTITCNRGYTLKIHRDDDIIKTQSESTVTLTCADGKWNKQVTCEPVDCGRPDKYHVHPAVFEFSEGTTYGKKCTFQCREPAQLVGSNNVLTCMEDGMWSFPEALCELRCPIPPPVPNAVLQTKRCNATGLKVGSFCKYKCKPGYHVPHIDKPKRSVPVMYHRRAFKRQCTEDGSWQFGECVAVTCEPPPPIFHGTYKCTNGFQFNSDCWIDCNRSNHTAPSTNVIRCRKDGNWTGSFRLCPNLTGQCSLPQNLSPNIHLSCKDGHGIGKECEVSCRDASSSVVLLPSNMSVAAVMKDHWWNPPKVKNIVCTMGLKWYPNPEALHCIKGCEPFMGDNYCDAINNRAFCNYDGGDCCHSTVKTKKVIPFPMSCDLREDCACRDPDAQENNKGARHRSIG
Protein: Histone H2A (Q5SQT3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU003767}.
Interaction partners:
Sequence:
MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQSKPKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEDIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKS
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) (Q9DC51)
Organism: Mus musculus (Mouse)
Function: Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08754}. Cell membrane {ECO:0000250|UniProtKB:P08754}; Lipid-anchor {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P08754}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. {ECO:0000250|UniProtKB:P08754}.
Interaction partners:
- Girdin
- Guanine nucleotide-binding protein G
- G-protein-signaling modulator 1
- Regulator of G-protein signaling 9
- Lysophosphatidic acid receptor 1
- D
- Sphingosine 1-phosphate receptor 1
- Relaxin receptor 1
- Gamma-aminobutyric acid type B receptor subunit 2
- G-protein-signaling modulator 2
Sequence:
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGESARADDARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
Protein: Uncharacterized protein, isoform A (Uncharacterized protein, isoform C) (Q9V3Y7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein, isoform A
- FI09204p
- Uncharacterized protein, isoform B
Sequence:
MQYSYLLAICVSLLLLKLKGAAATSLSAEPTPELLNAAKQIGLDEVGLREMWHSQQPLVIRTQNDAGQVTTLTYELGPDFRSILRRKVSEGILPARLEDNSGSKPQQDWEYVPSAGRQFRPIGDSNFGTGNFETKIFSTEFPRFPNWELPAGVTPKVTTKTETDSSGRKVTTTTRTYSGILVPGSNVFKQIFPDISREPGPINTDSNHPAENPNTSVFSPSRSPSTGPIDFNYVYNSRPSQREPVFVPVIDSTTTQRTSVPRFSSALPRDDGSDRVIDDYLKQVNLSASEIENSNGEVVKTIVDKNGRILTARFVLSSVKGTNEGSQQQRPTK