wanglab/gogpt-training-data huggingface dataset:
Protein: Anti-sigma factor RsrA (Regulator of SigR) (Sigma-R anti-sigma factor RsrA) (Q7AKG8)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: A redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigR, and a key sensor of disulfide stress. Holds SigR, its cognate ECF sigma factor, in an inactive form, inhibiting its sigma activity under reducing but not oxidizing conditions; oxidation and reduction of the anti-sigma factor is reversible. Mycothiol (MSH) is competent for reduction of RsrA, allowing it to bind to SigR. In conjunction with its cognate sigma factor SigR may sense the intracellular level of reduced MSH. Probably releases SigR during oxidative stress.
Interaction partners:
- ECF RNA polymerase sigma factor SigR
- RNA polymerase sigma factor
- Hydrogen peroxide sensing regulator
- Integral membrane protein
- Lipoprotein
- ECF sigma factor
- KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein
- RNA polymerase sigma-E factor
- ECF sigma factor
- ECF-sigma factor
Sequence:
MSCGEPHETDCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCLEKYGLEQAVKKLVKRCCGQDDVPGDLRAKVMGRLDLIRSGQSVPEHDVAAAPSSSAPQES
Protein: Transcription factor RHD6 (Basic helix-loop-helix protein 83) (AtbHLH83) (bHLH 83) (Protein ROOT HAIR DEFECTIVE 6) (AtRHD6) (Transcription factor EN 112) (Transcription factor bHLH83) (bHLH transcription factor bHLH083) (Q9C707)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that is specifically required for the development of root hairs. Acts with RSL1 to positively regulate root hair development. Acts downstream of genes that regulate epidermal pattern formation, such as GL2. Targets directly RSL4, another transcription factor involved in the regulation of root hair elongation. Acts with RSL1 as transcription factor that integrates a jasmonate (JA) signaling pathway that stimulates root hair growth.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17556585, ECO:0000269|PubMed:31988260}.
Interaction partners:
- Homeobox-leucine zipper protein GLABRA 2
- Transcription factor WER
- Protein ETHYLENE INSENSITIVE 3
- Expansin-A7
- Expansin-A18
- ETHYLENE INSENSITIVE 3-like 1 protein
- Respiratory burst oxidase homolog protein C
- MYB-like transcription factor ETC1
- Transcription factor EGL1
- Transcription factor GLABRA 3
Sequence:
MALVNDHPNETNYLSKQNSSSSEDLSSPGLDQPDAAYAGGGGGGGSASSSSTMNSDHQQHQGFVFYPSGEDHHNSLMDFNGSSFLNFDHHESFPPPAISCGGSSGGGGFSFLEGNNMSYGFTNWNHQHHMDIISPRSTETPQGQKDWLYSDSTVVTTGSRNESLSPKSAGNKRSHTGESTQPSKKLSSGVTGKTKPKPTTSPKDPQSLAAKNRRERISERLKILQELVPNGTKVDLVTMLEKAISYVKFLQVQVKVLATDEFWPAQGGKAPDISQVKDAIDAILSSSQRDRNSNLITN
Protein: Actin-related protein 2/3 complex subunit 2B (Actin-related protein C2B) (Arp2/3 complex 34 kDa subunit) (p34-ARC) (F4IVU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 5B
- Actin-related protein 2/3 complex subunit 5A
- At4g14145
- Actin-related protein 2/3 complex subunit 2A
- Guanine nucleotide-binding protein subunit beta
- Actin-related protein 3
Sequence:
MAYLERASPTLKETLLKIYRAEKPIEVDQHFHEFGSIEYHIKYSVSDPNIVHVSTSTLLETQGAVTLKEISSYTYEVIKNIGVGVIDIVDPPRLGFQLTLGLNLDNIPRGKEAIKIITRISELQAIILSSQLKEMLRSLNFQDDSRSINNMPIRIVYHPSEPFYVFKQPEKITAVFPMNFKDNSDVVIATSFFQELVEVGSQKDMGKAPQCSWSPIPPLQLRGEPVQDLTTNSGFVSFDITSRHIEGKRLDKTVWNLLNFYACAKYHIKCSRGYIQRRMRKRMETLVKLLNNTSLEEEAAQNENGRCKYVKEFVKVPKGKLMMKQRCKEMTRRVKISKFRIKINGCARFRFNQRWISLPKFSSKPSDKSYTKLD
Protein: Inhibitory synaptic factor 2A (InSyn2) (Q6ZSG2)
Organism: Homo sapiens (Human)
Function: Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.
Subcellular location: Postsynaptic density {ECO:0000250|UniProtKB:Q3USH1}.
Interaction partners:
- Inhibitory synaptic factor 1
Sequence:
MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSEEPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKTESKKHGRWKLWFL
Protein: Lipid droplet organization protein LDO45 (Lipid droplet organization 45 KDa protein) (P40218)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29187528}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:29187528}. Note=Contains a predicted membrane hairpin, a motif allowing association with both ER bilayers and LD monolayers. {ECO:0000305|PubMed:29187528}.
Interaction partners:
- Lipid droplet organization protein LDO16
- Protein LDB16
- Seipin
- Phosphatidylinositol transfer protein PDR16
- Uncharacterized protein YHR202W
Sequence:
MAARNRRKNNKKKSLLVTSAAQEKNATYVLVAEELHKKTIDLNMGTETPLTENHENPIPAKEFKHQQKLEPIDEHDDGEDELSIKFKSMTKSSGPITEAEVQKLLLSYAFTSAAIQEDENEKESRHYPIKPPSPSASSLSAYFQSFVEKCKQVFYNFSLQTVEKLNALQNSLYEVFWIIFIYLNYWFPNVGDYVSNTFGQQDSIIIRISLSKSHFRALREKSSQKVQQAVKNIYFCFQEKPYLTAFKVSFAIGLVIPCSLLFLIMVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS
Protein: Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) (Q8C3K6)
Organism: Mus musculus (Mouse)
Function: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:22124465, ECO:0000269|PubMed:28974690}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13866}.
Interaction partners:
- Predicted gene 5134
- Solute carrier family 2, facilitated glucose transporter member 2
- Epidermal growth factor receptor
- Solute carrier family 2, facilitated glucose transporter member 5
- Taste receptor type 1 member 2
- Solute carrier family 15 member 1
- Sodium/hydrogen exchanger 3
- Taste receptor type 1 member 3
Sequence:
MDSSTLSPAVTATDAPIPSYERIRNAADISVIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWNALVLVVVLGWIFVPIYIKAGVVTMPEYLRKRFGGKRIQIYLSVLSLLLYIFTKISADIFSGAIFINLALGLDIYLAIFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFNEVGGYEAFMDKYMKAIPTKVSNGNFTAKEECYTPRADSFHIFRDPITGDMPWPGLIFGLAILALWYWCTDQVIVQRCLSAKNMSHVKADCTLCGYLKLLPMFLMVMPGMISRILYTEKIACVLPEECQKYCGTPVGCTNIAYPTLVVELMPNGLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYTKIRKKASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEQGAFWGLILGFLIGISRMITEFAYGTGSCMEPSNCPKIICGVHYLYFAIILFVISVITILIISFLTKPIPDVHLYRWCWSLRNSKEERIDLDAGEEEDIPEDSKDTIEIDTEAPQKKKGCFRRAYDLFCGLDQDKGPKMTKEEEEAMKMKMTDTSEKPLWRTVVNINGIILLAVAVFCHAYFA
Protein: Nucleoporin nup131 (Nuclear pore protein nup131) (Q9P797)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular location: Nucleus {ECO:0000269|PubMed:15226438, ECO:0000269|PubMed:16823372}. Note=Nuclear rim.
Interaction partners:
- Nucleoporin nup85
- Nucleoporin nup107
- Nucleoporin nup189
- Nucleoporin nup120
- Nucleoporin seh1
- Protein transport protein sec13
- Nucleoporin nup132
- Uncharacterized protein ely5
- Probable nucleoporin C890.06
- Nucleoporin nup186
Sequence:
MFIVHRRFFQNEKAFTPAGKHEKVADGNKHETLATSEYPKVCASNDLYKILQISAPKVGNFTIHDAPVVGLIDSILEYYLYISVKVRKAWIAGYGSQPQNLICFDWERFTGILDQQSLNSPPLAGFVKPDPTSAEPGFLLLWPASGDLFYWERTSLMNVEVSAPEFPGFLHYRIQLKRYESCKNLVSAEPAGFFLTLSSGRLLHLNLKDSDGNSSIQVRILFPGLHIPNCLLSLYNSIFAFTSGRVIPIRCGSIKGPGERLVYSMHSGSTLRIWEIFGTGDHHLLRGFDIYDIILDSIQESFSYVNRFLILDFSVSTSDPYTLACLVSWRDNASLFNYAAIIISFNHQMIPHVSQFCHVRSYLSAILPSVCRIFLPSPGTVVFCVFDVTFAMFHKVRGKEGTFYVEENLVVNNLTSKSRVLDFGMEDAIYEKSTHTLLKTPALILLTEGHGIIRIESSASYLKTSFSATTYLRSRLSQFASQSPLFREQFLLNFDFTYNLSESEVYNTVFNLCDELYTTPCKKNMSVLETLHSQQRDLMEIVLVAFKYLHLSPSNRLQLWLKVAYCSALADLYELLMCNEKMSNLLRRVLKIMSSNDNIDELFLKKCLNINLLLQHLSSEYSQISGQDASNAQKRIEVIVNVNNVYGTIFGNELAYRQEKISKFTDPSSVIRSDLWTVEVDHLDLLRKQIEDSISLHRDVRDSKDAHILKVSNKLRKQILHLVEQNCLLIFDLHNGTDDTIVKSHNFQKFEEEFGNSRKEWLQYLASVGYLEKAIDLAEKVKDFQTMVILLDCLDPKDPTIKLQKQKACLNKYKEEFADVIFFYLVDTEQYASLLHDFLEYQSLLISFFEANDLLNLLWIFEAQNGNYGRASEILFRDCEPEENRIIGKISQLALAKLYSWTNRIEGENIILSNETEVIENHLAILLIQEQYAEMLSSLVDITEDEGEAVEAIVTSNCVNLSENSIRAWLVSSAVERLIQNEYTTLCEMVDFFSSFSLRECSFKEVDLALELLERATITKDVYFYLKDLVYRRFLLQVNWAEIIDAHEDLESSFFPMVKEIMLESDFLIWLQHMEHNIHDESKHYLKSEKNFLQSVYSSLSESQVEDYQMELFREKQIFSVLCKDRELYILIPKLLDVATKQ
Protein: Leucine-rich repeat-containing protein 27 (Q9C0I9)
Organism: Homo sapiens (Human)
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- Probable ATP-dependent RNA helicase DDX6
Sequence:
MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDLSELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKELPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEVLKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ
Protein: ATPase cation transporting 13A2 (A0A0G2JX15)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQLFTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRYYILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGIPVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQSMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECVVNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVKEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVALAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSRTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNGATRTEEHCGQLFQVAAAGSGRLQLCGRLHAGERAGPVSPSLPAVAAA
Protein: GDNF family receptor alpha 3 (F7F1M3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MYINVLVACTSVHYMCPVPLVTLWTHLISALAGNSLPTENRLVNSCTQARKKCEANPACKAAYQHLDSCTPSLSSPLPSGESATSAACLEAAQQLRNSSLIDCRCHRRMKHQATCLDIYWTVHPVRSLGDYELDVSPYEDTVTSKPWKMNLSKLSMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGIRCQRHLCLAQLRSFFEKAAESHAQGLLLCPCAPEDAGCGERRRNTIAPSCALPSVAPNCLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFISKVNTTVALGCTCRGSGNLQDECEQLEKSFSQNPCLMEAIAAKMRFHRQLFSQDWADSTFSVMQQQNSSPALRPQLRLPVLSFFILTLILLQTLW
Protein: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (A0A1D8PEG2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating
- 6-phosphogluconolactonase-like protein
- Glucose-6-phosphate isomerase
- Glucosamine/galactosamine-6-phosphate isomerase domain-containing protein
- Glyceraldehyde-3-phosphate dehydrogenase
- Transketolase
- phosphoglucomutase
- Transaldolase
- Phosphotransferase
- Triosephosphate isomerase
Sequence:
MSFDSFGDYATIVVFGASGDLAKKKTFPALFGLFREKQLPSTVQIIGYARSHLEDEEFKQRISEHFKGGDEKTKTEFLKLVSYISGPYDTDEGYKKLESRCQEYEKANKDKNDSYTPERLFYLALPPSVFTTVCEKVKKNVYPPEESKGKLRIIIEKPFGRDLDTYREMQKEISPLFTEDEIYRIDHYLGKEMVKNLLVLRFGNELFSGVWNNKHISSIQVSFKEAFGTEGRGGYFDTIGIIRDVMQNHLLQVLTLLTMERPVSFDPEAVRDEKVKVLKAFDAIDINDVILGQYTKSEDGKKPGYLDDKTVNPDSKAVTYAAFRVNIHNERWDGVPIVLRAGKALDESKVEIRIQFKPVAKGMFKEIQRNELVIRVQPNEAIYLKINSKIPGISTETSLTDLDLTYATRYSKDFWIPEAYEALIRDCYLGNHSNFVRDDELDVSWKLFTPLLNAVEDPAKKIELQYYPYGSKGPKDLRKYLNEHGYIFSDPGTYQWPLTSPNVKGKI
Protein: Afadin, adherens junction formation factor (H0Y7R8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQVRSSRPAMLLQ
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) (P16298)
Organism: Homo sapiens (Human)
Function: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19154138}.
Interaction partners:
- Calcineurin subunit B type 1
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Calcineurin subunit B type 2
- Calmodulin-1
- Calmodulin-like protein 3
- Calmodulin-like protein 5
- Calmodulin-like protein 4
- Calmodulin-like protein 6
- Calcipressin-3
Sequence:
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ
Protein: Repressor of RNA polymerase III transcription MAF1 (D5GB06)
Organism: Tuber melanosporum (strain Mel28) (Perigord black truffle)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037240}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase III subunit RPC6
- 
- DNA-directed RNA polymerase
- DNA-directed RNA polymerase
- 
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase
- DNA-directed RNA polymerase
- 
Sequence:
MKFLPLRELDSINRALVFDTPDCRVVGGVDIYTTKAAGADKKLYKNVCETISTRYEADLRLSESLSPPDRGSDSASKYQSAAVYQTLHSPFGPLDQISARRTFAYLIATLNASHPDYDFSTTLRPSDFRRERHIRPVMNNFNTTLFNLGVNTSRELPKMWETIDKEMDLLNCNIYAYSPDDVSNDPYGDEGLIWSTNLFFFNKHKKRVCYLYLRGLSTLNHSPLERSLAGWGRNSRVGSDGWDESEGEDLNDDFIESKSIWGDDNYDDGFFEGMEV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0B4KHX7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2-alpha kinase
- Aspartyl-tRNA synthetase, mitochondrial, isoform A
- Tyrosine--tRNA ligase
- Eukaryotic translation initiation factor 5
- Bifunctional glutamate/proline--tRNA ligase
- Cryptocephal, isoform A
- Eukaryotic initiation factor 4A
- Guanine nucleotide exchange factor MSS4 homolog
- Eukaryotic translation initiation factor 2A
Sequence:
MADEKAKESFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRDSSNGLETYVCTKLHVTCPSKYPKLPPKISLEESKGMSDQLLEALRNQLQAQSQELRGEVMIYELAQTVQAFLLEHNKPPKGSFYDQMLQDKQKRDQELQDIQRQRESLQRQTLIDEVERRKEMFKTEAKRRGEPRRSMSESNPRHPSSSESSENSSPYYRGHIYPSKCLDHRNTETLYFHKMGRQIQRGCCVGEGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIGGGKCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLVQDFLLGTSVFSISSSLGWCMDGARMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPNLLELLSGAGQSSSCGDLPALGALVESLMPTNSYEMRDFVDKCNSDRTLSASELLEHPFLRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNPVIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDLRTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALFEGTMDFIESRISRFQFHSSITGIMEKSRTSAQTLMDMLLANFLLTGSRSTVDDSALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSGHPSVLAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSLDKLVAAVGVEYAKDCRAIDVGICVCGTRPPLKDVTYIMRLLWSVGIRCGIVEAASELGDEAQDLARLGALHVILVAENGSLRVRSFERERFQERHLTRTELVEFIQKMLRSDGLNGTTVDNFSQLSALGSGDNRSSGGKERERGENGLSTSASNATIKNNYSQLPNLQVTFLTHDKPTANYKRRLENQVAQQMSSTLSQFLKKETFVVLVVELPPAVVNAIVGAINPREIRKRETEPEINYVIERFSKYKRYISEINEEVVDYLSDAKTPIVALYSISDSYYRVII
Protein: BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15) (Q8K0E1)
Organism: Mus musculus (Mouse)
Function: During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:25187989}.
Interaction partners:
- SUMO-conjugating enzyme UBC9
- Glucosamine-6-phosphate deaminase 2
- Transmembrane protein 18
- Protein transport protein Sec16B
- Mitochondrial carrier homolog 2
- Neuronal growth regulator 1
- SH2B adapter protein 1
Sequence:
MPHRKERPSGSSLNAHGSSGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKANAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPDDFKDFNLLYEEARYYQLQPMVRELERWQQDQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQRGFSVAASCGGGVDSSQFSEYVLCREERRPQPTPTAVRIKQEPLD
Protein: Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (Q6GQM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- ornithine decarboxylase
- Agmatine ureohydrolase
- Spermidine synthase
- Amine oxidase.
- Amine oxidase [flavin-containing]
- Amine oxidase
- Inosine triphosphate pyrophosphatase
- Transcriptional and immune response regulator a
- Acyl-CoA thioesterase 9, tandem duplicate 1
Sequence:
MAKFILRKAEPKDVSDILRLIKELAKFEEMEEQVVLTEKELLEDGFGDHPFYHCVVAEVPKDNQSIEGYTVVGFAMYYFTYDPWIGKLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRGASDLSHEEGWRLYEIDKCNLLKMSSK
Protein: CTD phosphatase subunit 1 (A0A8I6AIS1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
VSIVALAVKAVQPHQQQMFGEELPESQDGEQPGPARRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSESEKKKAEDQDSEQERARKPRKPRAPGTRREQPAGLPSPGERSAAGTRAPRGHKRKLNEEDAASESSGESSNDDEEGSSSEADEMAAALEAELNDLM
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit) (Q9P0J0)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:15367666}; Single-pass membrane protein {ECO:0000255}; Matrix side. Nucleus {ECO:0000269|PubMed:12628925}. Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment. {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:15059901}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 3
- NADH-ubiquinone oxidoreductase chain 2
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
- NADH dehydrogenase 1 alpha subcomplex subunit 7
Sequence:
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT