wanglab/gogpt-training-data huggingface dataset:
Protein: Nascent polypeptide-associated complex subunit beta-2 (NAC-beta-2) (BTF3 homolog BTT1) (Beta-2-NAC) (P40314)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the nascent polypeptide-associated complex (NAC), which promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane. Also blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. BTT1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. {ECO:0000250}.
Interaction partners:
- Nascent polypeptide-associated complex subunit alpha
- Protein CAF130
- General negative regulator of transcription subunit 1
- Nascent polypeptide-associated complex subunit beta-1
- General negative regulator of transcription subunit 5
- CCR4-associated factor 16
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- Protein CAF40
- CCR4-associated factor 4
- Large ribosomal subunit protein uL23
Sequence:
MPVDQEKLAKLHKLSAANKVGGTRRKINKKGNLYNNNDKDNTKLQAELHKLHPMTIENVAEANFFKKNGKVLHFNSAVVQIAPQCNLTMIHGQPKENTLNGLYPSVASQLGSQELEYLTGLAHNLENEQTVLDQLGDRCSETKQQVMNS
Protein: Secernin-1 (Q12765)
Organism: Homo sapiens (Human)
Function: Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK
Protein: LYR motif-containing protein 4 (Q0VCG0)
Organism: Bos taurus (Bovine)
Function: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9HD34}. Nucleus {ECO:0000250|UniProtKB:Q9HD34}.
Interaction partners:
- Cysteine desulfurase
- Frataxin, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- Ferredoxin-2, mitochondrial
- Acyl carrier protein, mitochondrial
- Selenocysteine lyase
- Cytosolic iron-sulfur assembly component 3
- Iron-sulfur cluster assembly factor homolog
- Adrenodoxin, mitochondrial
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Sequence:
MAASSRAQVLDLYRAMLRESKRFGAYNYRTYAIRRIRDAFRENKNVKDPVEIQALVNKAKRDLGIIRRQVHIGQMYSTDKLVIENQEKPRA
Protein: Eukaryotic translation initiation factor 3 subunit 8, putative (Q38AD5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RNA-binding protein, putative
- Elongation initiation factor 2 alpha subunit, putative
- protein-synthesizing GTPase
- Translation initiation factor, putative
- Eukaryotic translation initiation factor 5, putative
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 1A, putative
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- CSN8/PSMD8/EIF3K domain-containing protein
Sequence:
MADFFNVSDSDESIDEVIQRDDQVERNTAQIDPKWFEITDDEAAEEQRVVLSRREKSLNEIQTNADVFDFNVDQGTWVGAEQSFKELREKSDIHKRRFQSTPFPFLECLRNTPDLKTHLSERESFAKPEEFRSLKGLIKAVEEAMETYKDDIERLYDEEDGDEGDEEEAEKELTEDDIVKQLRESVTCTGKKASKYRKLANECKRKGYKALQITTCGIVADALLEEDNREVYVSTKTWAKSCDTLEECFGLIVENPGIRLSDKFSDKLNKRDAFIKGGLHALLQSLSKHLRRITQFKDGIPSDYIEIVHLENRLVAIADALFGYYRDNSRGRAVCCQILVDILGSRRQEAHEILFGKMPPGQREAVSDSVIETVRSLYEQLLLIGDDESKSLALLHLVYQMGLEGKYREGRDLIRRSGGAEKLCNSNHNSVLYNRAVAQLGLASFIMGDIMQAYELLSPLWNSWEGPEVLIGQKLPNLKDEKGDEELRYRDLLLPPHAHIPYSQLELATMLSTLVVGTVDEAKKPYEVTHHHRYFYRVINQMQFQPLLGEPIEFREQITAAYTALKLGDYARSSEVIKNMKVWDNMPRGTEARDTFLQRLKEAALQIFCYNSRRSFATISVEIMAKKFDITESTVKHVINGIISENNTPLIAVWDRDDQYLHVDRSNISRLQYLVEATARSVENIAHYCEKGGHGNDFRGGRGQGYMRGGRGFGRGGGSDFRGAADYGRGRGRGRARGGQ
Protein: Long-chain fatty acid transport protein (Outer membrane FadL protein) (Outer membrane flp protein) (P10384)
Organism: Escherichia coli (strain K12)
Function: Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}.
Interaction partners:
- Long-chain-fatty-acid--CoA ligase
- Acyl-coenzyme A dehydrogenase
- Outer membrane protein W
- Fatty acid oxidation complex subunit alpha
- Outer membrane protein A
- Maltoporin
- 3-ketoacyl-CoA thiolase FadA
- Fatty acid metabolism regulator protein
- Outer membrane protein X
- Outer membrane porin C
Sequence:
MSQKTLFTKSALAVAVALISTQAWSAGFQLNEFSSSGLGRAYSGEGAIADDAGNVSRNPALITMFDRPTFSAGAVYIDPDVNISGTSPSGRSLKADNIAPTAWVPNMHFVAPINDQFGWGASITSNYGLATEFNDTYAGGSVGGTTDLETMNLNLSGAYRLNNAWSFGLGFNAVYARAKIERFAGDLGQLVAGQIMQSPAGQTQQGQALAATANGIDSNTKIAHLNGNQWGFGWNAGILYELDKNNRYALTYRSEVKIDFKGNYSSDLNRAFNNYGLPIPTATGGATQSGYLTLNLPEMWEVSGYNRVDPQWAIHYSLAYTSWSQFQQLKATSTSGDTLFQKHEGFKDAYRIALGTTYYYDDNWTFRTGIAFDDSPVPAQNRSISIPDQDRFWLSAGTTYAFNKDASVDVGVSYMHGQSVKINEGPYQFESEGKAWLFGTNFNYAF
Protein: Regulatory protein VirG (P07545)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Function: VirG is required for the positive regulation of at least two vir loci encoded by the Ti plasmid of A.tumefaciens.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MAGQDPRLRGEPLKHVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSKQFNRVLCSETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGARLEEADKVIALELGATDFIAKPFGTREFLARIRVALRVRPSVARTKDRRSFSFADWTLNLRRRRLISEEGSEVKLTAGEFNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLEGDPTTPQLIKTARGAGYFFDADVDVSYGGVMAA
Protein: ATP-dependent RNA helicase p62 (EC 3.6.4.13) (P19109)
Organism: Drosophila melanogaster (Fruit fly)
Function: As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, rRNA processing and miRNA processing, as well as transcription regulation (By similarity). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92841}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92841}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q92841}. Note=In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication. {ECO:0000250|UniProtKB:Q92841}.
Interaction partners:
- Fragile X messenger ribonucleoprotein 1 homolog
- Centrosome-associated zinc finger protein Cp190
- H/ACA ribonucleoprotein complex subunit 4
- Pescadillo homolog
- Nucleolar protein 58
- Probable ATP-dependent RNA helicase spindle-E
- Probable ATP-dependent RNA helicase pitchoune
- LD07162p
- Purine-rich binding protein-alpha, isoform B
- Nucleolar GTP-binding protein 1
Sequence:
MLKLVQYIAPRVGGATPRPTACGWGNLLLISPRSGASSEKCITQRRHFLFSSASSSGTFASSSSLCTEQRQQFHGSRRNRETILFPSTYSSLQAQSQRAFRDSSKPDSDDYVDSIPKAEQRTRTRKSLFNDPDERTEEIKIEGVMAPHDRDFGHSGRGGRGGDRGGDDRRGGGGGGNRFGGGGGGGDYHGIRNGRVEKRRDDRGGGNRFGGGGGFGDRRGGGGGGSQDLPMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREEQEITVRGQVPNPIQDFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENLARNSRYDGGGGRSRYGGGGGGGRFGGGGFKKGSLSNGRGFGGGGGGGGEGRHSRFD
Protein: Cilia- and flagella-associated protein 157 (Q0VFX2)
Organism: Mus musculus (Mouse)
Function: Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27965440}.
Interaction partners:
Sequence:
MAPKKKPNKGGKEMQGKKIGGKKDASGTKTPELAMVEELKEFYHKQIQDLEDRLARYQRKWDELAVREKLFHQEFEQLANNKKEIVAFLKRTLNQKVDEITDLNDQLQSLEVAKDMEKDAFEAQLAQVRHEFQEIKDQLTTENIALGIKLSSLEEFRLQKEELTEKYLALEEQLHRQEGEYKEYVYNLEKKSVLDKDRLRKEIIQRVNLVATEFRKMATNQMWETTRRAILENNSVTLQLNKVSKHGVQLLQENEQLKGTQNKLCQQLEMLENTQEIMARKNIGHKKIILMLTEKCRQQRKGTEETEQLRLLLSQLEQNFQNVQRDNQTLRSEKDQLEAQLKEKQAEANRLQEELTKEQKIRANLKTVLIQATSMLQDIVHMQTEAEDGDFDVVFQLQRKELLQQLLVLLSSGVVLKTQPDMGSHQDKQPQGLSKESQRITQTSKEGAVSLLQQLSTITTYKPGDLGLVPRRPVRIPLKPQDLRPLSYITRMGICQNTNEIYPSGALKRFRKFTLPRPFLHRK
Protein: FIP1[V]-like protein (AtFIP1(V)) (Factor interacting with poly(A) polymerase 1-like 5) (AtFIPS5) (Protein HOMOLOG OF YEAST FIP1 [V]) (F4KDH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential gene. Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6UN15, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Polyadenylate-binding protein 3
- Nuclear poly
- 30-kDa cleavage and polyadenylation specificity factor 30
- Cleavage and polyadenylation specificity factor subunit 2
- Pre-mRNA cleavage factor Im 25 kDa subunit 1
- Nuclear poly
- Cleavage stimulation factor subunit 77
- Polyadenylate-binding protein 2
- Pre-mRNA cleavage factor Im 25 kDa subunit 2
- Nuclear poly
Sequence:
MEEDDEFGDLYSDVLQPFQPPVVLPPPPPLPHRSIDLNLRSQDQDVSEPNSAPISRVSDNDAVKLSTQDATRQAIVDGGGDDKDMSFDIEEPDADSTPTIPGLFVTGALPGLATDRGVSQVTTRIEQQVGGGGDGGYGGQGEGDDWDSDSEDDLQIVLNDSSRNVMIGGADRRSRMGDNEDDDDEDDEDPLVIVADTDPNQPMEEQMWGEDGLQGIEGDGKDGGEAGKGSGPGGATGPPKAGYSSHGYHPFHSQFKYVRPGAAPIPGGAASVGGPSSGQVRPPANLGPMAGRGRGDWRPLGMRNASAAQKGFHQPWGSNTAGRGLDFTLPSHKTIFEVDIDSFEEKPWRYPGVEMTDYFNFGLNEESWKDYCKQLDQHRIQTTMQSRIRVYESGRTDQGYDPDLPPELAAATGAQGVPVDSSNLVKPDSVQGDSAKVPANVRPTLPPGRPIPVETGSGERLPSIDTRAPRMRDLDAIIEIVCQDSHEDEPSGENGTDQADSSLPGENVPVETSYVNNKRPDTESAEHSPAQDEPHKNLLKKQDDEISRSTDSGQSFRSSSPVGDRGTRSSSVDREDVGGEAGKDAEMGEELKMSFTSPQSAVQEDDGGESKTERSSESSKARSGSHRDFQQEEDVIQDKHSSRPANNRKQYDNNAPHQSRKNQDRGKEMERTRAASKGGRENSNPHMELDSTYIYSIASREDFDKRKERDVDGAVWRRKEDDPYSRRGGDEGSRKRDREDDPGFRQRGKMRENEIRSKDDQVPSRKHMDDAGMRNIYEPDDHINKRRKDEEYLRRSRPEKNEISYGQRESMSRVKRERDDRLEHQKRDVQHKIRDDFDDHGSLRQRDDIYMQRDGNERLRERDVLDKLKLPHEDGISARGRERQVAVRGHRGSEDRSSRMKDEYKASDKEHVTKDTLRHAKQTKRRDYPGEESSSHHRGHEDFSARTDNIVNNEKKPRQERTGAKIDKFIDTLDGQRLQDRKHKDSRRKIKEQREGTESLSKQGEQNGSSVVTGSKGTNDARNCRSEIPHQPNTAKRHKENASSGDEIHDSKRGRTKLERWASHKEREDAVSAKSSSISSKLEEKENNTNGRLSEPVHGSIGKSRDVTEEKIGHDLADTKDGSEKGPGDRHLDTVEKLKKRSERFKLPMPTEKDTTGVKKMESETLPSAKIEGPVDSEGEYVWDERSCVRIGREYA
Protein: Development and carotenogenesis control-1 protein (Q7SFA8)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
Sequence:
MTLQDTTKFRTSAEDVTNPCTDLPKASAFGITTTVSGDSSQLLTNLSPASGRSVPVTHLNHLQAKDRTKTHQLSDQTAGTQDGRPPGVWAPNSGRYGPIADKAPHEHLGALSIPPISGHSGHPQPLATPPFEVGPGGAQLTLGKRITAEDKSELRSFDSPSKKTLLVAHGGLHLPPPLPHTPGELVSYLPGVSSPLFFSHRARQQPPTPRMPGFFANGIAAPIMSIVQETQDGVTTLRLPKGHVIATTAQGSNRSSSTPGSWTSSESLDGTMRSLDGRPLAIVAPALQAIPATELLDQDPRPVFIVDLANPFNVSSGLLHIVYANPSLKASTSVLELLNGDTADAEADSFDFAHFKHWVMSPEANTESIRLAPTCTTFGGINWTCSTLRKRFRVVTGHSNTVSVTPTTPSPKTQLPPVLSRSSRGSISARELSPERGDAVDYFGPVEEVGSPRPRSYSEPRSPSRTIIDTSLAGLNELPMVIPMSQVYTTFDWTRIPVDDPNLGPHHRFARSVDWASTPLGPVEEWPADLRIMSNMIMGSPHPAALYWGEEFVAIYNEAYIALAGKKHPQLMGAKYKDAWAEIWDEIEPVFDAAWNDGSATMKHDDGLFITRNGFLEETFFNWGIIPLVGGDGTVVALYNPAFENTRRKINERRMLTLREVGVRTSEARDVKGFWSMLLQGLEYNGLDVPFALVYSVTEDPESEVASINSGSVTNPPQITLEGSVGVPEGHPTAVQSIDLRTSDEGFAPYMRDSMAHPGNPIILSEDDGSLPHELIKGFDWRGFGDPCRTIVVFPVHPTTAGDMVVGFIVLGVNPRRQYDEDFELFVNLLSRQLATSMASVVLFEEEIKRGQRAARLAALDRQQLSMQLHLRTQEAVESEYRFARMAELGPVGLFIADSHGRINYCNEMWWRISGHERSASTLDAWMQSIRDEDREGVVNVWHHLVQEKVPVTYEFRFNGTRKIVDGHTVDTWALMSAYPERDETGELKSIFGCITDISQQKWAEDFQKRRRDEAVELKRQQENFIDITSHEMRNPLSAILQCADEIASGLNRFRQENPAFRGPDTLETLVDSCLEAANTISLCASHQKRIVDDILTLSKLDSQLLLVTPVDVQPVQVVEEVLKMFEAELNSNDITGHFQIEQSYRNLEIDWVKLDPSRLKQVLINLMTNAIKFTQGRPTRAITINLGASKDVSSAGLSYFPPRHPDQEDLTDDAEWATGEKINLHLAVSDTGPGLDENEKKILFQRFSQTSPRTHVQYGGSGLGLFICRILTELQGGQIGVYSEKGEGSTFAFYVKSRKAENPQPVPTVVDNSMSIQPLQQRVSPQTQGQISHRSSSSAAFSLLGHGRSHAPPTRTQSAPVLADTTQTRSLDVLIVEDNLVNQRVLQRQLQLSGNNTFVANHGGEALVELRKSRFWNKEIAATDDAASALPRSNKKAVNDGGTDGSPDGEENSNNNISVILMDLEMPVMDGMSCTREIRRLENVGVITRHIPIIAVTAYARPEQVESARAAGVDDVISKPFRLPELIPKIEELVLKYDREP
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) (Q9H4L7)
Organism: Homo sapiens (Human)
Function: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.
Subcellular location: Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage.
Interaction partners:
- Transcription intermediary factor 1-beta
- DNA mismatch repair protein Msh2
- Zinc finger protein 93
- Exonuclease 1
- Histone H2A type 2-A
- Histone H2A type 2-C
- DNA topoisomerase 2-binding protein 1
- Histone deacetylase 1
Sequence:
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQYIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEYDSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALFTKMSKTNGLSEDLIWHCKTLIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNIEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYRHINNFQLDMDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEGDEGSMPADIATLLKTSMGL
Protein: N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) (Q8BG18)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12044471}.
Interaction partners:
Sequence:
MEDSRETSPSSNNSSEELSSTLQLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPSKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSSPALLEEDNQWMTQINRLQKLIDRLEKKDLKLEPLEEEIIEENTKPHIMLVQRQMSVTEEDLEEFQLALKHYVESASAQSGCLRISIQKLSNESRYMIYEFWENSSVWNRHLQTNYSKTFQRSNVDFLETPELTSTMLVPASWWILNNN
Protein: Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) (P41586)
Organism: Homo sapiens (Human)
Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Subcellular location: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:36385145}.
Interaction partners:
- Pituitary adenylate cyclase-activating polypeptide
- VIP peptides
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Pro-glucagon
- Probable non-functional immunoglobulin heavy variable 3-16
- Secretin
- BDNF/NT-3 growth factors receptor
- Guanine nucleotide-binding protein G
Sequence:
MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
Protein: Muscarinic acetylcholine receptor M5 (P08911)
Organism: Rattus norvegicus (Rat)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Metabotropic glutamate receptor 5
- Muscarinic acetylcholine receptor M1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit gamma
- Muscarinic acetylcholine receptor M3
- Guanine nucleotide-binding protein subunit gamma
- Kininogen-1
- Neuronal acetylcholine receptor subunit beta-2
Sequence:
MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
Protein: Protein PAM71-homolog, chloroplastic (GDT1-like protein 2) (PHOTOSYNTHESIS AFFECTED MUTANT71-homolog) (Q9T0H9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable chloroplast-localized Mn(2+)/H(+) and/or Ca(2+)/H(+) antiporter regulating Ca(2+), Mn(2+) and pH homeostasis.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:18431481}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Alpha/beta-Hydrolases superfamily protein
- 6,7-dimethyl-8-ribityllumazine synthase
- Uncharacterized protein At5g03900
- Zinc finger/BTB domain protein
- Putative DNA
- Low-density receptor-like protein
- Inner membrane localized protein
- Protein FATTY ACID EXPORT 3, chloroplastic
- Mitochondrial substrate carrier family protein
- Ribosomal RNA small subunit methyltransferase J
Sequence:
MKLTSLSKNANSTATAVTVSSIQKLPFLSLSETLPCPKSSRKPTFLPLRCRRRPKLDLLWGKFRVRASDAGVGSGSYSGGEEDGSQSSSLDQSPATSSESLKPRGPFPYSLSIALVLLSCGLVFSLITFVKGGPSSVLAAVAKSGFTAAFSLIFVSEIGDKTFFIAALLAMQYEKTLVLLGSMGALSLMTILSVVIGKIFQSVPAQFQTTLPIGEYAAIALLMFFGLKSIKDAWDLPPVEAKNGEETGIELGEYSEAEELVKEKASKKLTNPLEILWKSFSLVFFAEWGDRSMLATVALGAAQSPLGVASGAIAGHLVATVLAIMGGAFLANYISEKLVGYVGGALFLVFAAATFFGVF
Protein: Multiple antibiotic resistance protein MarB (P31121)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Multiple antibiotic resistance protein MarA
- Multiple antibiotic resistance protein MarR
- Regulatory protein SoxS
Sequence:
MKPLSSAIAAALILFSAQGVAEQTTQPVVTSCANVVVVPPSQEHPPFDLNHMGTGSDKSDALGVPYYNQHAM
Protein: Ankyrin 2 (A0A5F9ZHC9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKELTEELGELEASSDEEAMVTTRVVRRRVIIQGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEDNNE
Protein: Stromal cell-derived factor 2, putative (EC 2.4.1.109) (B9RNW9)
Organism: Ricinus communis (Castor bean)
Interaction partners:
- DnaJ protein ERDJ3B
- Endoplasmin homolog
- Heat shock protein binding protein, putative
Sequence:
MAIAFFVLSIFLFLNLDLDYGSFTSASAATSSSSESVEITYGTVLKLMHERTKFRLHSHDVPYGSGSGQQSVTGFPNVDDSNSYWIVRPQPDTGAKQGDAIKSGTIIRLQHMRTRKWLHSHLHASPISGNLEVSCFGGESDSDTGDYWRLMIEGSGKTWKQDQRIRLQHVDTGGYLHSHDKKYQRIAGGQQEVCGVREKRADNVWLAAEGVYLPVTESK