wanglab/gogpt-training-data huggingface dataset:
Protein: Subtilase cytotoxin subunit B (Q6EZC3)
Organism: Escherichia coli
Function: Receptor-binding subunit of subtilase cytotoxin SubAB5. Required for receptor-binding and thus correct trafficking in the host cell. Has specificity for host glycans terminating in the sialic acid N-glycolyl-alpha-neuraminic acid (Neu5Gc); each subunit in the SubB pentamer binds one Neu5Gc. The protease subunit (SubA) cleaves host BiP/HSPA5, inducing the host endoplasmic reticulum stress response and eventual cell death. Culture supernatant of E.coli expressing both subA and subB are toxic for Vero cells (African green monkey kidney cell line), Chinese hamster ovary cells and Hct-8 cells (human colonic epithelial cell line); the subunits are not toxic individually. Purified SubAB5 is highly toxic, <0.1 pg is able to kill at least 50% of 30'000 Vero cells in a microtiter plate assay after 3 days; no cytotoxicity is seen at 24 hours. Preabsorption with cells expressing a ganglioside GM2 mimic reduced cytotoxicity of SubAB5 by 93% in the Vero cytotoxicity assay. Intraperitoneal injection of 200 ng of purified SubAB5 kills mice; the higher the dose the faster the mice die. Animals injected with purified SubAB5 have microvascular thrombi in the brain and other organs, including the renal tubules and glomeruli. Mice fed E.coli cells expressing cloned SubAB5 experience drastic weight loss and appear ill and lethargic. SubB alone at 2.5 ug/ml causes vacuolation of Vero cells, which requires the V-type ATPase proton pump; treated cells die. Protein synthesis in Vero cells is transiently inhibited by SubAB5; both subunits are required for this effect. Inhibition of protein synthesis is prevented by brefeldin A; cells are arrested in the G1 phase. SubAB5 at 100 ng/ml induced caspase-dependent apoptosis in Vero cells through mitochondrial membrane damage.
Subcellular location: Secreted {ECO:0000269|PubMed:15226357}. Host cytoplasm, host cytosol {ECO:0000269|PubMed:15226357, ECO:0000269|PubMed:17101670}. Host endoplasmic reticulum lumen {ECO:0000305|PubMed:17024087, ECO:0000305|PubMed:18005237, ECO:0000305|PubMed:23921389}. Note=Colocalizes with host BiP/HSPA5 in the endoplasmic reticulum of Vero cells, its activity on BiP/HSPA5 is blocked by pretreatment with brefeldin A, which disrupts the Golgi apparatus and inhibits retrograde transport from the cell surface to the Golgi (PubMed:17024087, PubMed:18005237). Using different inhibitors it has been shown to be actively internalized by membrane-bound vesicles and undergoes clathrin-dependent retrograde transport, via early endosomes and the Golgi network, to the endoplasmic reticulum (PubMed:18042253). Trafficking is similar in Vero cells, human HeLa cells and murine N2A cells (PubMed:18042253). {ECO:0000269|PubMed:15226357, ECO:0000269|PubMed:17024087, ECO:0000269|PubMed:18005237, ECO:0000269|PubMed:18042253}.
Interaction partners:
Sequence:
MTIKRFFVCAGIMGCLSLNPAMAEWTGDARDGMFSGVVITQFHTGQIDNKPYFCIEGKQSAGSSISACSMKNSSVWGASFSTLYNQALYFYTTGQPVRIYYKPGVWTYPPFVKALTSNALVGLSTCTTSTECFGPDRKKNS
Protein: Multifunctional dioxygenase prhA (EC 1.14.11.-) (Paraherquonin biosynthesis cluster protein A) (A0A1E1FFL0)
Organism: Penicillium brasilianum
Function: Multifunctional dioxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity). Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity). The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B. The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK. Finally, prhA leads to berkeleydione via the berkeleyone B intermediate. PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione. Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable). The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable). Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
Interaction partners:
Sequence:
MAPMIPPRLQRFPATASADEIFAAFQEDGCVVIEGFISPEQVARFSQEVDPAMEKIPVEVTNNGNSNDRTKRFSKCVIASPTFRNEIIESDLMHELCDRVFSKPGEGMGYHFNDNMVIEVQPGAPAQRLHRDQELYPWWNSMGPAGPECVINFFCAVTPFTEENGATRLVPGSHLWPEFTQINERDCPQFGKIETVPAIMQPGDCYLMSGKVIHGAGHNATTTDRRRALALAIIRRELRPMQAFSLSVPMKLAREMSERSQTMFGFRSSVQHCDVDMVHFWGNDGKDIAHHLGLEAPSVHV
Protein: AP-5 complex subunit mu (Adaptor protein complex AP-5 subunit mu) (Adaptor protein-5 mu-adaptin) (Adaptor-related protein complex 5 subunit mu) (Mu5-adaptin) (Q8W0Z6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Beta-adaptin-like protein B
- AP-2 complex subunit alpha-2
- AP-4 complex subunit sigma
- AP-1 complex subunit gamma-2
- Beta-adaptin-like protein A
- AP-4 complex subunit epsilon
- AP-1 complex subunit gamma-1
- AP-1 complex subunit sigma-2
- AP-1 complex subunit sigma-1
- Clathrin heavy chain 1
Sequence:
MPSGCSIRALWIINNQDTVVFSRRFPVVEKQWCSAYKTENENTGLDLPRLPTDQQISDSFTRRKRREGSTRGYGIRVAQSTKGSDSWVDDPITRHIISLCLTEEDDDDDDERNILWPIALHTKALYSILVLPLVEPKEMKDYVKLCRRSDCGPAVGEDLSLSSLLLNISSITGAFMVAHAFGDIISGDTVEPEVVVSVSPSVGGLFDSLTGSIGISSRAKPVAAPVASSNPSGAAITGATASDAPKAGSRLLDRDLLRNFIATAMPFGTPLDLSLSNISAMKANGFSSADPPPQELKQPAWKPYLYKGKQRLLFTIHETVSAAMYDRDEIPDNVSVAGQINCRAELEGLPDVSFPLAGLSTAHIEAISFHPCAQVPAHGIDKQNIVFQPPLGNFVLMRYQAGCGLGPPVKGFYQLSMVSEDEGAFLFKVHLMEGYKAPLSMEFCTITMPFPRRRIVAFDGTPSAGTVLTTEHSVEWRILGSGRSLSGKSLEATFPGTIKFSPLQSRRKGDGDDEESEDESAENVVNVEDFLVQKMNKDLPAAELEEPFCWQAYDYAKVSFKIVGASVSRMSIDTKSVNIYPTTKSPVEFSAQVTSGDYILWNTLGKAPSAAVV
Protein: COMPASS component SWD3 (Complex proteins associated with SET1 protein SWD3) (Set1C component SWD3) (P38123)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
- COMPASS component SWD1
- COMPASS component SWD2
- COMPASS component SHG1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- COMPASS component BRE2
- COMPASS component SDC1
- COMPASS component SPP1
- Histone H3
- E3 ubiquitin-protein ligase BRE1
- Polyubiquitin
Sequence:
MFQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRWV
Protein: Probable aquaporin NIP5-1 (NOD26-like intrinsic protein 5-1) (AtNIP5;1) (Nodulin-26-like major intrinsic protein 6) (NodLikeMip6) (Protein NLM6) (Q9SV84)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Boric acid transporter. Low water transport activity. Plays an important role as plasma membrane boric acid channel for the boron uptake required for plant growth and development under boron limitation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16679457}; Multi-pass membrane protein {ECO:0000269|PubMed:16679457}.
Interaction partners:
- Boron transporter 4
- Probable aquaporin SIP2-1
- Boron transporter 1
- Probable aquaporin SIP1-2
- Probable boron transporter 2
- Aquaporin SIP1-1
- Probable boron transporter 7
- Probable boron transporter 3
- NEP1-interacting protein 2
- Katanin p60 ATPase-containing subunit A1
Sequence:
MAPPEAEVGAVMVMAPPTPGTPGTPGGPLITGMRVDSMSFDHRKPTPRCKCLPVMGSTWGQHDTCFTDFPSPDVSLTRKLGAEFVGTFILIFTATAGPIVNQKYDGAETLIGNAACAGLAVMIIILSTGHISGAHLNPSLTIAFAALRHFPWAHVPAYIAAQVSASICASFALKGVFHPFMSGGVTIPSVSLGQAFALEFIITFILLFVVTAVATDTRAVGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVASGNYRSLWVYLVAPTLGAISGAAVYTGVKLNDSVTDPPRPVRSFRR
Protein: Probable inactive leucine-rich repeat receptor-like protein kinase At3g03770 (Q8LFN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Ribosomal L18p/L5e family protein
- 16 kDa phloem protein 1
- Probable protein phosphatase 2C 79
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Splicing factor Cactin
Sequence:
MEKLYCGMPLLLLVLLLASIDGSTQLQSSQSQTLLRLQQLLYYPKVLNSWNNYTDFCNSEPSPSLTVVCYEDSVTQLHIIGDNGTHMLPKSFSINSFVTTLVKLPDVKVLTFVSLGLWGWLPQKINRLSSLEILNVSSNFLFGPIPHELSSLATLQTLILDENMFSGELPDWIDSLPSLAVLSLRKNVLNGSLPSSLSSLSGLRVLALANNRFNGALPDLSHLTNLQVLDLEGNSFGPLFPRLSNKLVTLILSKNKFRSAVSAEEVSSLYQLQHLDLSYNTFVGPFPTSLMSLPAITYLNISHNKLTGRLSANLSCNSQLMFVDMSSNLLTGSLPTCLKPSSGTSRDVVYASNCLATTNEDQRPVSFCSNEALAVGILPQRRNKVSKVGIALGVTASILGVLLLAGALFVVLRRLNAKKTVTKSSPRLIRENASMGYTSKLLSDARYISQTMKLGGLGLPAYRTFSLEELEYATNNFESSAFMGEGSQGQIYRGRLKDGSFVAIRCLKMKKSCSTQNLMHHIELIAKLRHRHLVSVLGHCFECYLDDSTVSRMFFVFEYVPNGELRTWISDGHMGRLLTWEQRISVAIGVAKGIQFLHTGIVPGVYDNNLKMTDILLDNNLAAKLSSYNLPLLVEGLGKVGQVGSRSGPKGTPSIKDEDKIDIYDFGVILLELIVGRPLRAKSQVDVLKEQLQASISADDGARRSMVDPTVHRACSDQSLKTMMEICVRCLLKDPLERPSIEDVLWNLQFASQVQEGWLQNSNPSSNLGSPSPAASSLPPPSRLHVTTLESPRDSGCEEHER
Protein: Light-harvesting complex protein binding chlorophyll d (Q6Q975)
Organism: Acaryochloris marina
Subcellular location: Cellular thylakoid membrane {ECO:0000256|ARBA:ARBA00004636}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004636}.
Interaction partners:
Sequence:
MQTYGQTDVEYGWWSGNSRFSDYSGQFLAAHNGQIASMCFWAGSFTLFEVSRFNPDLPVYQQNLVCIPQLARAGWGVAAGGAVVDTYPYFAIAMIHLVAAAILGAGALYGVTKGPKVLADSEFSGAQRFHFEWDDFETQGRILGHHLLVLGAACLLFATWACTHGVYDPVAGEVRAISPSLNLVRFFKYGWATPGFNPYFVNNLEDVIGGHFFVSSLYIAGGIWHILVKPWPYTDKIFVKSGEALLAYALAGLAFAGFNAAYFCSVNDVVFPVELFGPVLEAKLNVTPYFAETLDASDGGHTTRFWISNFHYYWAFYCLQGHLFHALRSYGFDFRRIPRALASLTPQAN
Protein: Gut esterase 1 (EC 3.1.1.1) (Non-specific carboxylesterase) (Q04457)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum lumen.
Interaction partners:
- Esterase cest-33
- Cytidine deaminase
- Cytidine deaminase
- Carboxylic ester hydrolase
- Beta-glucuronidase
- Myosin-3
- Myosin-2
- Cuticle collagen dpy-7
Sequence:
MRIFLVSVILINACWAGPIVETNYGKVEGIEYEGAEVFLAIPFAKPPVDDLRFEKPVAPDPWEDVYPATQYRNDCTPHYRLVAQFSSYSGEDCLTLNIIKPKKAEKLPVLFWIHGGGYEIGSASQHGYEFFAKRYASQGVIVATVQYRLGFMGFFSEGTSDVQGNWGLFDQAAALEFVKSNIENFGGDPNQITIWGYSAGAASVSQLTMSPYTRDSYSKAIIMSASSFVGWATGPNVVETSKQLAEILGCPWPGAKECMKKKSLHEIFDAIEVQGWTTGTIDILRWSPVIDGDFMTKNPEELIKESPVKPTLIGMSNKEGSYFAALNMGRVIADFGLSPEDMPKVDEEFISEIIGRKLLYNNRYGENREKVWNDILDFYVKQGKPAEVKDLNGFYVDRYSELLSDITFNVPILREITSRVERKTPVWTYRMDHYDKNIWKKHIPEQARGSPHANEYHYLFDMPVMAKIDMKKEPDSWIQNDLIDMVISFAKTGVPQIEDVEWRPVSDPDDVNFLNIRSDGVSIEHGLFQEPLAFWNELRQREGFDLIDPTNSAMHSSNKDEL
Protein: Fumarate hydratase 2 (Fumarase 2) (LmFH-2) (EC 4.2.1.2) (E9AE57)
Organism: Leishmania major
Function: Cytosolic fumarate hydratase that catalyzes the reversible hydration of fumarate to (S)-malate.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22569531}.
Interaction partners:
- Putative malic enzyme
- malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- malate dehydrogenase
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Fumarate hydratase 1, mitochondrial
- Citrate synthase
Sequence:
MSLCDQCEIGCRRVGIKDIEDASAVNADFHFSAIFQPTDPHHHQTEFAKVEGSEKYVEEVEVFGRQALKVNPEALTILAHRAFSDVHHFFRKDHLEGWRRAIEDPEASDNDRYVATTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCWTGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSDYEFLFIAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTMKTVKLASCRYYDSLPTTGDKYGRAFRDPEWEKIVMEVAQKSGIGAQFGGKYFAHQARVIRLPRHGASCPVGLAVSCSADRQILAHINKSGIYIEQLEQNPAQYLPDIPEVHLSTTSVKVDLKRPIDKVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGEPLPEYMKTSPIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDACKKHGGFYLGSIGGPAAILAKDSIKQVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSKTLA
Protein: Protein S40-2 (AtS40-2) (Q9FK78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20238146}.
Interaction partners:
- At5g43150
- Mitochondrial carrier protein MTM1
- F-box protein At1g61340
- Probable LRR receptor-like serine/threonine-protein kinase At2g23950
- GATA transcription factor 15
- WD repeat-containing protein RUP2
Sequence:
MSEEFQESDIIFSDQSKISTSSRYTKLYNSRNDEKKGTRRHETAEKTSPVRIPTNNFRCLEWDTTEEEDDKTPPHVIIERRMKEQIAFSACTLKGRDLSRHRNSVLRMTGFLEA
Protein: Zinc finger CCCH domain-containing protein 30 (AtC3H30) (P93755)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Zinc finger CCCH domain-containing protein 46
- Zinc finger CCCH domain-containing protein 62
- Zinc finger CCCH domain-containing protein 28
- Zinc finger CCCH domain-containing protein 55
- Zinc finger CCCH domain-containing protein 51
- Zinc finger CCCH domain-containing protein 59
- Zinc finger CCCH domain-containing protein 1
- Putative protease Do-like 13
- AT4g16790/dl4420c
- NADH-ubiquinone oxidoreductase chain 3
Sequence:
MCCGSDRLNQIVSSRSSLPISFEEDNNLVTNTDMNHLTVETEDTFASLLELAANNDVEGVRLSIERDPSCVDEAGLWYGRQKGSKAMVNDYRTPLMVAATYGSIDVIKLIVSLTDADVNRACGNDQTTALHCAASGGAVNAIQVVKLLLAAGADLNLLDAEGQRAGDVIVVPPKLEGVKLMLQELLSADGSSTAERNLRVVTNVPNRSSSPCHSPTGENGGSGSGSPLGSPFKLKSTEFKKEYPVDPSLPDIKNSIYATDEFRMYSFKVRPCSRAYSHDWTECPFVHPGENARRRDPRKFHYSCVPCPDFRKGACRRGDMCEYAHGVFECWLHPAQYRTRLCKDGTGCARRVCFFAHTPEELRPLYASTGSAVPSPRSNADYAAALSLLPGSPSGVSVMSPLSPSAAGNGMSHSNMAWPQPNVPALHLPGSNLQSSRLRSSLNARDIPTDEFNMLADYEQQQLLNEYSNALSRSGRMKSMPPSNLEDLFSAEGSSSPRFTDSALASAVFSPTHKSAVFNQFQQQQQQQQSMLSPINTSFSSPKSVDHSLFSGGGRMSPRNVVEPISPMSARVSMLAQCVKQQQQQQQQQQQQHQFRSLSSRELRTNSSPIVGSPVNNNTWSSKWGSSNGQPDWGMSSEALGKLRSSSSFDGDEPDVSWVQSLVKETPAEAKEKAATSSSGEHVMKQPNPVEPVMDHAGLEAWIEQMQLDQLVAQQN
Protein: Calcium channel, voltage-dependent, alpha 2/delta subunit 1a (E7F4T2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSVRRMMDALRLSTALLLLLSLCSFGSAIQFPDSFLTRKWAEKMQEDLVQLIDSESGIKELKKIFNNFQRHYTVRQNNPRQLVEKASHEIEEFLANRSKALEALATAAENLQKEHQWKEDLDVNETIYYNAKDKSDNQTEPRKNRLILDFTEDPAFKRPVSYNTTAVHIPTDIYEGSTIILNELNWTAALDDVFRKNKEDDPSLHWQVFGSATGLARYFPASPWVDSKNKIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNIVSFNNSAKSVACFENLVQANVRNKKTLKEAVQKITANGTTDYKIGFKEAFNQLASMNVSRANCNKIIMLFTDGGEDKASEIFDEYNSDKRVRIFTFSVGQHNYDKAPIQYMACHNKGYYYEIPSIGAIRINTQEYLDVLGRPMVKADKKAKNVQWTNVYVDALELGLVVTGTLPVFNKTRTSKEKPKGKNLGPSQMILGVMAIDVSLDDIKRLTPHYTLGPNGYYFAIDPNGYVLLHPNLQPKDLKSQEPVTLDFLDAEMEDEVKVDIRRSMIDGERSQIRFHTLMKSQDERYIDKGFRTYTWSPVTDADYSLALVLPDYSMSYIKATIGDTITQAKSWILENLAVSESLQVDKFEEYGYTLIAPRDYCEDLKAQNENMTQFLIDFNEYIDVKTPNDPQCNMDLMNRLLLDAGITAELVKHWNKNQLSDRIKAKFVATDGGVTRVYPASAGSEWTGQAETYESSFYKRSLDNDLYVFTPLPFTGNKTEESVLVSRAMDLRIDEFWLKPAVVGVKLDVQSWMESFMNTTITPKCEGEICGCRRNDEYLDCVLLDDGGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRSVYVPTIADILNIGWWASAAAWSIMQQLFVSITFPNFLEAVDISDESETPSKESCIKEQTQYFFDSNDTTFKGTVDCQNCSRQFIAEKLMKTNLVLIVADTEMCSQMCEEKPFSQEEKPSPGPDPCLISQNPRYRKGPMECFDNNVNENNEPCGGATSLTPSLVSMGILQLLLLLWLLIGREHCLS
Protein: Transcription initiation factor TFIID subunit 11 (TBP-associated factor 11) (AtTAF11) (Q9M565)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 4b
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 12b
- Transcription initiation factor TFIID subunit 4
Sequence:
MKHSKDPFEAAIEEEQEESPPESPVGGGGGGDGSEDGRIEIDQTQDEDERPVDVRRPMKKAKTSVVVTEAKNKDKDEDDEEEEENMDVELTKYPTSSDPAKMAKMQTILSQFTEDQMSRYESFRRSALQRPQMKKLLIGVTGSQKIGMPMIIVACGIAKMFVGELVETARVVMAERKESGPIRPCHIRESYRRLKLEGKVPKRSVPRLFR
Protein: DENN domain-containing protein 1B (Connecdenn 2) (Q3U1T9)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P3S1}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q6P3S1}.
Interaction partners:
- Ras-related protein Rab-35
- DENN domain-containing protein 1A
- 14-3-3 protein epsilon
Sequence:
MDRRTRENPERTFDLVLKVKCHASENEDPEVLWKFPEDFGDQEVLQSVPKFCFPFDVERVSQNQVGQHFTFVLTDMESKQRFGFCRLTSGGRICLCILSYLPWFEVYYKLLNTLADYLAKELEEDLNETLKSLYNHPVPKANTPVNLSVHSCFITPDITGLPTIPESRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVVLNVDTNTLESPFNDLSSLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGRLAKLNAGRGFSDIFEEEITSGGFCGGSPRSYQQWVYTVKKGGALFNTAVTKATPAVRTAYKFAKSHARLGLKEVKSRLKHKDNEEEYGTCSGLVQYTPVYTLHNEKGENREKHKLSQTHLKRPHKSLDGTLYDDDDDDDDIERASKISSEDGEETRAYFYESDDSVEAQVKAPYSGEMDLLGEILDTLSTHSSDQGKLAPAKSLDFFRSMDDIDYKPTNKSNAPSENNLALLCASGDQGEWNLGQDDSALHGRQLPPSPRKRVSSGGLTESLFILKEESREKPLCADSVSGPTVVGKPAPTSGLRSQPAAPEASQTERGRAEVKQTPGQAPLQSEDLSVPGPGSRQSTFVPWEKAGKEDTKPSKDVGLLQEVVSLCHMSCDFQQDLNISEESRSGNQT
Protein: Metabotropic glutamate receptor 6 (mGluR6) (P35349)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells (By similarity). {ECO:0000250}.
Interaction partners:
- Nyctalopin
- Metabotropic glutamate receptor 2
- Transient receptor potential cation channel subfamily M member 1
- Calcium-binding protein 4
- Guanine nucleotide-binding protein G
Sequence:
MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
Protein: Outer envelope protein 80, chloroplastic (Chloroplastic outer envelope protein of 80 kDa) (AtOEP80) (Protein TOC75-V) (AtToc75-V) (Q9C5J8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an essential role during early stages of plastid development.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:12034753, ECO:0000269|PubMed:15255865}.
Interaction partners:
- Mitochondrial import receptor subunit TOM40-1
- Outer envelope pore protein 37, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- UPF0548 protein At2g17695
- Translocase of chloroplast 159, chloroplastic
- Protein TIC 40, chloroplastic
- Protein TIC110, chloroplastic
- Protein TOC75-3, chloroplastic
- Translocase of chloroplast 33, chloroplastic
- Protein TIC 22-like, chloroplastic
Sequence:
MHCHNDDVRFSSSSIRIHSPSPKEQHSLLTNLQSCSKTFVSHLSNTRNSLNQMLQSLKNRHTPPPRSVRRPNLPTQMLNSVTQLMIGKSSPISLSLIQSTQFNWSESRDENVETIRGLSSPLLCCASLSLTRPNESTQSVEGKDTVQQQKGHSVSRNAEERVLISEVLVRTKDGEELERKDLEMEALAALKACRANSALTIREVQEDVHRIIESGYFCSCTPVAVDTRDGIRLMFQVEPNQEFRGLVCENANVLPSKFIHEAFRDGFGKVINIKRLEEAITSINGWYMERGLFGIVSDIDTLSGGIVRLQVAEAEVNNISIRFLDRKTGEPTKGKTSPETILRQLTTKKGQVYSMLQGKRDVDTVLAMGIMEDVSIIPQPAGDSGKVDLIMNCVERPSGGFSAGGGISSGITSGPLSGLIGSFAYSHRNLFGRNQKLNVSLERGQIDSIFRINYTDPWIEGDDKRTSRSIMVQNSRTPGNLVHGNQPDNSSLTIGRVTAGVEYSRPFRPKWNGTAGLIFQHAGARDEQGNPIIKDFYSSPLTASGKPHDETMLAKLESIYTGSGDQGSTMFAFNMEQGLPVLPEWLCFNRVTGRARKGIHIGPARFLFSLSGGHVVGKFSPHEAFVIGGTNSVRGYEEGAVGSGRSYVVGSGELSFPVRGPVEGVIFTDYGTDMGSGSTVPGDPAGARLKPGSGYGYGLGVRVDSPLGPLRLEYAFNDQHAGRFHFGVGLRN
Protein: Zinc finger protein 69 (hZNF3) (Q9UC07)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPCCSHRRCREDPGTSESQEMDPVAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVGKSWKDQNIEYEYQNPRRNFRSLIEKKVNEIKDDSHCGETFTQVPDDRLNFQEKKASPEIKSCDSFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYHPSFRTPQRDHTGEKPYACKECGKTFISHSSIQRHVVMHSGDGPYKCKFCGKAFHCLSLYLIHERIHTGEKPYECKQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHERIHTGEKAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQCGKALSSLTSFQTHIRMHSGERPYECKICGKGFCSANSFQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTHVRIHSGERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQCGEAFSSSSSFRYHERTHTGEKPYKCKQCGKAFRAASVLRMHGRTHPEDKPYECKQ
Protein: Uncharacterized protein YPL108W (Q02872)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- UPF0651 protein YPL107W
- Putative uncharacterized protein YPL136W
- Putative 2-hydroxyacid dehydrogenase YPL113C
- Inner membrane assembly complex subunit 17
Sequence:
MKEASDREEAPKMVEKNYSTGFRKAHGEKDQSVTKPISLDGRTGEVIVRKSTGKTKIRKGQTEEEYTQQLQHYFEVEQGPVRTKVGWMDEVDPLVEIREGKYDISNKHQRQVLSGFCHRLFYQCKYKECLDLSTYFLGLFEPFNVKNKMKRELEELEYMIERCRGHVL