wanglab/gogpt-training-data huggingface dataset:
Protein: Multiple C2 and transmembrane domain containing 2 (F5H415)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEALAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDSEEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKDGHFGH
Protein: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12) (Q99258)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (Probable). Has also an unrelated function in expression of mitochondrial respiration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12595523, ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Mitochondrion intermembrane space {ECO:0000269|PubMed:12595523}.
Interaction partners:
- 6,7-dimethyl-8-ribityllumazine synthase
- Riboflavin synthase
- GTP cyclohydrolase-2
- Bifunctional protein RIB2
- 2,5-diamino-6-ribosylamino-4
- Riboflavin kinase
- Vacuolar protein-sorting-associated protein 60
- Pantoate--beta-alanine ligase
- Flavin adenine dinucleotide synthase
- Bud site selection protein 4
Sequence:
MFTPIDQAIEHFKQNKFVIVMDDAGRENEGDLICAAENVSTEQMAFLVRHSSGYVCAPMTNAIADKLDLPLLRTGMKFESNDDDRHGTAYTITVDVAQGTTTGISAHDRSMTCRALADSSSTPKSFLKPGHICPLRAADGGVLQRRGHTEAGVDLCKLSGLSPVAVIGELVNDDEQGTMMRLNDCQAFGKKHGIPLISIEELAQYLKK
Protein: Reticulocalbin-1 (Q05186)
Organism: Mus musculus (Mouse)
Function: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Subcellular location: Endoplasmic reticulum lumen.
Interaction partners:
Sequence:
MARGGRLGLALGLLLALVLALRAKPTVRKERVVRPDSELGERPPEDNQSFQYDHEAFLGKEDSKTFDQLSPDESKERLGKIVDRIDSDGDGLVTTEELKLWIKRVQKRYIYDNVAKVWKDYDRDKDEKISWEEYKQATYGYYLGNPAEFHDSSDHHTFKKMLPRDERRFKASDLDGDLTATREEFTAFLHPEEFEHMKEIVVLETLEDIDKNGDGFVDQDEYIADMFSHEDNGPEPDWVLSEREQFNDFRDLNKDGKLDKDEIRHWILPQDYDHAQAEARHLVYESDKNKDEMLTKEEILDNWNMFVGSQATNYGEDLTKNHDEL
Protein: ER membrane protein complex subunit 4 (A8MQD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 1
- Membrane magnesium transporter
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 7 homolog
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit-like protein
- ER membrane protein complex subunit 8/9 homolog
Sequence:
MDKGKAVMGTGRRWAVEFSDQSTVPSSRDILDPPGFSRASQEQDDSANSRQKKDAEATWKLQKAWEVAQSPFKNLMMMGFMMWMAGNTVHLFSIGITFSALWQPISALQSVGKIFEPFKDNKVELLMPKLVFLALNLGGLALGVWKLNTLGLLPTHASDWVSSLPPPQLNTRAEDLFSTDESASLVF
Protein: Uncharacterized protein C5H10.07 (Q09678)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTVLTSYKLYCGPDFPAPLEKKEKREKGKIRNISFLIVLTKGPIWKVSSMESTSYNGCIENLDCKFRKSFIEEIIAYEGFGKYIEVINF
Protein: AH domain-containing protein (E1B6R3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSRIPTGIKVPDVVANIDTAQVAAKVESFKKWTIGTFKNSKQQLLEHMGKIDKTVDPEFEAQCEVLKDIHRRYGLVVAAAKNFSHVLTQMAEAEKKLSESFYQLSMKEEQIKAQCTMTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAATNPPQGQLTKNLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLLEASVRELSFLQSPQPSFIPTM
Protein: Histidine kinase of the competence regulon, ComD (Q8DS94)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Interaction partners:
- Response regulator of the competence regulon, ComE response regulator of sakacin A production
- Competence stimulating peptide
- Periplasmic sugar-binding protein
- Glucosyltransferase-SI
- Glucosyltransferase-I
Sequence:
MNEALMILSNGLLTYLTVLFLLFLFSKVSNVTLSKKELTLFSISNFLIMIAVTMVNVNLFYPAEPLYFIALSIYLNRQNSLSLNIFYGLLPVASSDLFRRAIIFFILDGTQGIVMGSSIITTYMIEFAGIALSYLFLSVFNVDIGRLKDSLTKMKVKKRLIPMNITMLLYYLLIQVLYVIESYNVIPTLKFRKFVVIVYLILFLILISFLSQYTKQKVQNEIMAQKEAQIRNITQYSQQIESLYKDIRSFRHDYLNILTSLRLGIENKDLASIEKIYHQILEKTGHQLQDTRYNIGHLANIQNDAVKGILSAKILEAQNKKIAVNVEVSSKIQLPEMELLDFITILSILCDNAIEAAFESLNPEIQLAFFKKNGSIVFIIQNSTKEKQIDVSKIFKENYSTKGSNRGIGLAKVNHILEHYPKTSLQTSNHHHLFKQLLIIK
Protein: Gibberellin 20 oxidase 3 (EC 1.14.11.-) (GA 20-oxidase 3) (Gibberellin C-20 oxidase 3) (Q39112)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key oxidase enzyme in the biosynthesis of gibberellin that catalyzes the conversion of GA12 and GA53 to GA9 and GA20 respectively, via a three-step oxidation at C-20 of the GA skeleton, and GA25 is also formed as a minor product. GA53 is less effectively oxidized than GA12.
Interaction partners:
- Ent-kaurenoic acid oxidase 2
- Ent-kaurenoic acid oxidase 1
- Gibberellin 3-beta-dioxygenase 1
- Gibberellin 3-beta-dioxygenase 4
- Gibberellin 3-beta-dioxygenase 2
- Gibberellin 3-beta-dioxygenase 3
- Gibberellin 2-beta-dioxygenase 6
- Gibberellin 2-beta-dioxygenase 4
- At3g21570
- Gibberellin 2-beta-dioxygenase 3
Sequence:
MATECIATVPQIFSENKTKEDSSIFDAKLLNQHSHHIPQQFVWPDHEKPSTDVQPLQVPLIDLAGFLSGDSCLASEATRLVSKAATKHGFFLITNHGVDESLLSRAYLHMDSFFKAPACEKQKAQRKWGESSGYASSFVGRFSSKLPWKETLSFKFSPEEKIHSQTVKDFVSKKMGDGYEDFGKVYQEYAEAMNTLSLKIMELLGMSLGVERRYFKEFFEDSDSIFRLNYYPQCKQPELALGTGPHCDPTSLTILHQDQVGGLQVFVDNKWQSIPPNPHAFVVNIGDTFMALTNGRYKSCLHRAVVNSERERKTFAFFLCPKGEKVVKPPEELVNGVKSGERKYPDFTWSMFLEFTQKHYRADMNTLDEFSIWLKNRRSF
Protein: Multidrug resistance protein MdtM (Multidrug resistance transporter MdtM) (MDR transporter MdtM) (Multidrug transporter MdtM) (P39386)
Organism: Escherichia coli (strain K12)
Function: Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22426385, ECO:0000269|PubMed:23701827, ECO:0000269|PubMed:27025617}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein YjiL
- Multidrug resistance protein MdtG
- Multidrug resistance protein MdtH
- UPF0382 inner membrane protein YgdD
- Multidrug resistance protein MdtK
Sequence:
MPRFFTRHAATLFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLIAPIIGPLSGAALMHFMHWKVLFAIIAVMGFISFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFCNRLFLFGAATISLSYIPMMSWVAVSPVILIDAGSLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLSLLIVGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFSNKLPKGTVSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVRQHQAAELVEEQ
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A1P8BAS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MVFPQRLYLHALLVACCCVLLLADAQRTHPSEVTALRSVKRSLLDPKDYLRNWNRGDPCRSNWTGVICFNEIGTDDYLHVRELLLMNMNLSGTLSPELQKLAHLEILDFMWNNISGSIPNEIGQISSLVLLLLNGNKLSGTLPSELGYLSNLNRFQIDENNITGPIPKSFSNLKKVKHLHFNNNSLTGQIPVELSNLTNIFHVLLDNNKLSGNLPPQLSALPNLQILQLDNNNFSGSDIPASYGNFSNILKLSLRNCSLKGALPDFSKIRHLKYLDLSWNELTGPIPSSNFSKDVTTINLSNNILNGSIPQSFSDLPLLQMLLLKNNMLSGSVPDSLWKNISFPKKARLLLDLRNNSLSRVQGDLTPPQNVTLRLDGNLICTNGSISNANLFCESKGKEWISLPNNSTNSALDCPPLACPTPDFYEYSPASPLRCFCAAPLRIGYRLKSPSFSYFPPYIDQFGEYVTDFLQMEPYQLWIDSYQWEKGPRLRMYLKLFPKVNETYTRTFNESEVLRIRGIFASWRFPGSDLFGPYELLNFTLQGPYSYVNFNSERKGVSWRRLAAITAGAVVTAVAISAVVAALLLRRYSKHEREISRRRSSSKASLLNSGIRGFSFKELAEATDDFSSSTLVGRGGYGKVYRGVLSDNTVAAIKRADEGSLQGEKEFLNEIELLSRLHHRNLVSLIGYCDEESEQMLVYEFMSNGTLRDWLSGSNSQ
Protein: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) (P9WNP7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the NAD-dependent oxidation of beta-hydroxybutyryl-CoA to acetoacetyl-CoA in vitro at pH 10. Also catalyzes the reverse reaction albeit in a lower pH range of 5.5-6.5. The reverse reaction is able to use NADPH as well as NADH.
Interaction partners:
- Putative acyltransferase Rv0859
- Probable beta-ketoacyl CoA thiolase FadA3
- Probable acetyl-CoA acetyltransferase
- Probable enoyl-CoA hydratase EchA8
- Steroid 3-ketoacyl-CoA thiolase FadA6
- Steroid 3-ketoacyl-CoA thiolase
- Probable acetyl-CoA acyltransferase FadA2
- Probable enoyl-CoA hydratase EchA17
- Possible lipid carrier protein or keto acyl-CoA thiolase
- Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3
Sequence:
MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY
Protein: Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)] (Q62598)
Organism: Rattus norvegicus (Rat)
Function: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Integrin beta-6
- Integrin beta-1
- Lipid droplet-regulating VLDL assembly factor AUP1
- Dentin matrix acidic phosphoprotein 1
- E3 ubiquitin-protein ligase synoviolin
- E3 ubiquitin-protein ligase AMFR
- CCR4-NOT transcription complex subunit 2
- ER membrane protein complex subunit 3
- Amelogenin, X isoform
- ER membrane protein complex subunit 4
Sequence:
MKTKIIIYICIWATAWAIPVPQLVPLERDIVEKSADVPFLAHPGTAAQNELHINNATNDDSPKGSELGRQVHSNGGYERDRNGSESIAVGGKSSPTQPILANAQGNSAKEREDVETYGHDGIHAGGENSTANGIRGQVGIAENAEEAKESKVHGQPHQDTKTGLASDTSQNGDATLVQENEPQVAGSKNSTNHEVGTHGSGVAAQETTPQREGEGSENQGAEVTPSIGEGAGLDNTEGSPSGNGIEEDEDTGSGDGVGADAGDGRESHDGTEGHEGQSSGGNNDNRGQGSVSTEDDDSKEQEGSPNGRGGDNTSSSEETGIEEGDGTQTTQDNQNLSPTEGGIISQAEACPSGQSQNQGLETEGSSTGNKSSITKESGKLSGSKDSNGHHGMELDKRNSPKQGESDKPQGAAEKSDTHNNMGHSRIGSSSNSDGHDSYDFDDESMQGDDPNSSDESNGSDGSDDANSESAIENGNHGDASYTSDESSDNGSDSDSHAGEDDSSDDTSDTDDSDSNGDDDSESKDKDESDNSNHDNDSDSESKSDSSDSDSDSSDSSDSSDSSDSSETSDSSDSSDTSDSSDSSDSSDSSNSSDTSDSSDSSDGDSSDGDSSDSDSSDSDSSNSSDSDSSDSSDSSSSDSSDSDSDSKDSTSDSSDDNSKSGNGNSDSDSDSDSDSEGSDSNHSTSDD
Protein: Protein maternal effect lethal 26 (Q94420)
Organism: Caenorhabditis elegans
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway.
Subcellular location: Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:22621901}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000269|PubMed:22621901}. Note=Colocalizes with unc-89 to the M line. {ECO:0000269|PubMed:22621901}.
Interaction partners:
- Cullin-3
- Meiotic spindle formation protein mei-1
- Meiotic spindle formation protein 2
- Copine family protein 1
- Cullin-1
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
- Fidgetin-like protein 1
- RING-box protein 1
- DUF1014-domain-containing protein
- Serine/threonine-protein phosphatase 4 regulatory subunit 1
Sequence:
MEPRIDGGVFIGGIGNSGNEMCSNGVPALGVSSQTEIKVEKVQHTWTVKNFSHCYQEYLENFVYLQRGDEQLTWSIKIYPKGNGENNKDFVFLCLNRVINNNVKAGKIGFKSQFKLRTAENKDIEMRIHPNPSHSDYVSYIKRDVLFPQIMPRDMIIVNVEIDVAVETITTTNEPIQFEPTNSEQQLIEDYQRLFSQELLCDFAINVNGKIIRAHKAVLAARSPVFNAMLTHQDTDEAKSSMMYINDMDYDVIYEMVYYIYCGRCNKDITDMATALLIAADKYRLEELKSHCEKYLVENINIENACSLLIIGDLYSAPKLRKRAVTYILARPKNVTGTPGWEDILKGHPNLITDIFSQIDRQSSTGATSSVSNLPGVPMDIPGITGNIVPPPSGL
Protein: Cytosolic Fe-S cluster assembly factor NUBP1 homolog (Nucleotide binding protein 1 homolog) (Q93459)
Organism: Caenorhabditis elegans
Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Regulates cilium formation and structure.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03038}. Cell projection {ECO:0000269|PubMed:23807208}.
Interaction partners:
- cysteine desulfurase
- Ribosome-recycling factor, mitochondrial
- Probable cytosolic Fe-S cluster assembly factor oxy-4
- beta-ketoacyl-[acyl-carrier-protein] synthase I
- Putative folylpolyglutamate synthase
- Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog
- E1 ubiquitin-activating enzyme
- NIF system FeS cluster assembly NifU N-terminal domain-containing protein
- NFU1 iron-sulfur cluster scaffold homolog
- Anamorsin homolog
Sequence:
MSDVPDDANAGCPGTGSAGAGKASGCAGCPNQGSCATGQGPPPDADVPKIQDRFSRIKHKILILSGKGGVGKSTLTSNLARALASDPSKQVAILDVDICGPSQPRMMGVEDEEVHNSADGWTPVGIQPNLTLMSIAFLLGDKNDAVIWRGARKNGMIKQFLKDVDWGEVDYLLIDTPPGTSDEHISLVQFLLQAGPLDGALIVSTPQEVSLLDVRKEVSFCVKTKVPILGVVENMARFVCPNCAHTTLLFPTSTGGAEQMCKDSNLELLAQLPLEPALAKALDNGEDFFETNPDSTLAKSFLDLAEKVKAKLV
Protein: TRMT1-like protein (EC 2.1.1.-) (A2RSY6)
Organism: Mus musculus (Mouse)
Function: May play a role in motor coordination and exploratory behavior.
Interaction partners:
- Transcriptional protein SWT1
- tRNA
Sequence:
MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSILLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW
Protein: Dicarboxylate carrier UCP2 (Mitochondrial uncoupling protein 2) (UCP 2) (Solute carrier family 25 member 8) (P56500)
Organism: Rattus norvegicus (Rat)
Function: Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis. Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate and phosphate (By similarity). Does not mediate adaptive thermogenesis (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P70406}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Leptin
- Peroxisome proliferator-activated receptor gamma
- Peroxisome proliferator-activated receptor alpha
- Insulin-1
- Insulin-2
- Sterol regulatory element-binding protein 1
- Tumor necrosis factor
- NAD-dependent protein deacetylase sirtuin-1
Sequence:
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGLARTAASAQYRGVLGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVEAYKTIAREEGIRGLWKGTSPNVARNAIVNCTELVTYDLIKDTLLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTMLRKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAAYESREAPF
Protein: NLR family CARD domain containing 3 (NOD3 protein, isoform CRA_d) (H3BLT9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEMDAPRPPSLAVPGAASRPGRLLDGGHGRQQVQALSSQLLEVIPDSMRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSNDSRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit (A0A8I6A6K6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRKKGSCLAPMTNPRRRRLVVRQVCKSSGQLEAQPPLGPGAARRRWRRDAERAECGRAEPEPERGRRSRAGCGPAEMPYKLKKDKEPPKLAKGTAKPSSSSKDGGGENTDTEAQPQPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
Protein: Cilia- and flagella-associated protein 141 (Q32L75)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}.
Interaction partners:
- Cilia- and flagella-associated protein 276
- Tektin-2
- Outer dynein arm-docking complex subunit 3
- Tektin-3
- Cilia- and flagella-associated protein 52
- Piercer of microtubule wall 1 protein
- Tubulin beta-4B chain
- Outer dynein arm-docking complex subunit 1
- Tektin bundle-interacting protein 1
- Methyl-CpG-binding domain protein 1
Sequence:
MSMEKMGKVEEHFQRALELKKMVHRWRNSHTHCLWQITLSQRRNPYAILRMQDTMVQELALANKQLLMVRQAALHQLFEKEHQQYQQELNEKGKAFYMERL
Protein: Ninjurin-1 (hNINJ1) (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1 (Soluble ninjurin-1)] (Q92982)
Organism: Homo sapiens (Human)
Function: Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis. Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells. Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions. Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS. Acts as a mediator of both programmed and necrotic cell death. Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Plays a role in nerve regeneration by promoting maturation of Schwann cells. Acts as a regulator of angiogenesis. Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity).
Subcellular location: [Ninjurin-1]: Cell membrane {ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:38396301, ECO:0000269|PubMed:39667936}; Multi-pass membrane protein {ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:39667936}. Synaptic cell membrane {ECO:0000250|UniProtKB:O70131}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secreted ninjurin-1]: Secreted {ECO:0000305|PubMed:32883094}.
Interaction partners:
- RNA-binding protein NOB1
- 26S proteasome non-ATPase regulatory subunit 8
Sequence:
MDSGTEEYELNGGLPPGTPGSPDASPARWGWRHGPINVNHYASKKSAAESMLDIALLMANASQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPLMDMAPQQ
Protein: Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (Protein EN-7) (p21-Rac2) (Q05144)
Organism: Mus musculus (Mouse)
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Membrane-associated when activated. {ECO:0000250}.
Interaction partners:
- NADPH oxidase 2
- Neutrophil cytosol factor 1
- Neutrophil cytosol factor 2
- Neutrophil cytosol factor 4
- Cytochrome b-245 light chain
- Dedicator of cytokinesis protein 2
- Proto-oncogene vav
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
- Rho GDP-dissociation inhibitor 1
- Nck-associated protein 1-like
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL