wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquitin hydrolase B (EC 3.4.19.12) (O96612)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for proper prespore cell patterning. Plays a role in stabilizing mkkA by preventing it from being targeted for degradation. ubcB and ubpB differentially control ubiquitination/deubiquitination and degradation of mkkA in a cell-type-specific and temporally regulated manner.
Interaction partners:
- RNA recognition motif-containing protein RRM
- Ubiquitin carboxyl-terminal hydrolase A
Sequence:
MKNIEEMPSKSQLVAHRSRGLINTSNTCFMNVILQSLTGCQLFLRVIKNLSDLEDLGKYPTLHSFNQFYTEYFSNPTSNILNNNSNSTTTTSSSSTTATTTSTSNNNKSQTPTSPIQQHHQSQTNGLSNQPSVATQSQQQQQPQPPINPKHFNDLVKSFNSKVSPVPQTTVSPHSMVQVSKKKLKLQLYNNSLPQTICQQDAQEFLVFLLDLIHEEFLTLIKDIDIPKEDDKSTPTSTSIVDDNWEVVGKKGKTAIITNSQQELPKTPISQIFSGVLRSSFNRTGSKESITVEPFYCLHLDIRPEEINSLEDALKFFMKPEIIEGYTCSTKKIEISASKSWSFESLPRILIVHFKRFAFESDTSKKLDKLIRFPTQLSLSTASNHQTQKKYSLFSVVSHHGRGLSQGHYTCDIYQPQQAQWIRYDDSTFTEVKEQDVLNREAYLLLYQLVN
Protein: Putative alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) (Q9VTJ4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Interaction partners:
- GDP-fucose protein O-fucosyltransferase 2
Sequence:
MAISAWMPLLVALIVVWISAAEVDAQVPGPRTRYQPNWASLDQRPLPQWYDDAKVGIFLHYGVYSVPSFGSEWFWTNWKNLRNPEYVQFMQRNYKPDFTYQEFASQFTAELFNATKWALLFKDSGARYVVLTSKHHDGFTLWPSKNSYGWNSMDVGPKRDIVKELAAAIRKESDLRFGLYYSLFEWFNPLWTDDKLHLLMQQHFVERKVRPEQMELVQQYLPEIIWSDGDWEAPAKYWRSEEFIAWLYNDSPVRDTVVTNDRWGFGTACMHGDFYNCADRFNPGVLQAHKWENAFTLDRTSWGQRFDVSLSDFMTSKEVIKEIITTVSCNGNVLINVGPTKFGTILPIFEERLRDMGRWLKFNGEGIYGSVPWIYQNDTINGNVWYTRQKEASNGKITIYAFVLEYPYDTNELDIYPLGKDINIFRNVMLTGIDMGTGGDILNEQSTEVVMLGMEDTKIKWNADHNRLHIVFPPKNHIDKRGLDYAWTFKITIT
Protein: Semaphorin-3A (Semaphorin III) (Sema III) (Q14563)
Organism: Homo sapiens (Human)
Function: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Plexin-A2
- Plexin-A3
- Plexin-A4
- Plexin-A1
- Neuropilin-1
- Neuropilin-2
- Plexin-D1
- Dihydropyrimidinase-related protein 3
- Plexin-B1
- Dihydropyrimidinase-related protein 1
Sequence:
MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV
Protein: N-acetyltransferase 8B (EC 2.3.1.-) (Acetyltransferase 1) (ATase1) (Camello-like protein 2) (Q9UHF3)
Organism: Homo sapiens (Human)
Function: May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons. May play a role in regulation of gastrulation (By similarity).
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19011241}; Single-pass type II membrane protein {ECO:0000255}. Note=Enriched in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}.
Interaction partners:
Sequence:
MAPYHIRKYQESDRKSVVGLLSGGMAEHAPATFRRLLKLPRTLILLLGGALALLLVSGSWILALVFSLSLLPALWFLAKKPWTRYVDIALRTDMSDITKSYLSECGSCFWVAESEEKVVGTVGALPVDDPTLREKRLQLFHLSVDNEHRGQGIAKALVRTVLQFARDQGYSEVVLDTSNIQLSAMGLYQSLGFKKTGQSFFHVWARLVDLHTVHFIYHLPSAQAGRL
Protein: Shadow of prion protein (Protein shadoo) (Q8BWU1)
Organism: Mus musculus (Mouse)
Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17703189}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17703189}.
Interaction partners:
- Prion-like protein doppel
- Major prion protein
- Mitochondrial ribosome-associated GTPase 1
Sequence:
MNWTAATCWALLLAAAFLCDSCSAKGGRGGARGSARGVRGGARGASRVRVRPAPRYGSSLRVAAAGAAAGAAAGVAAGLATGSGWRRTSGPGELGLEDDENGAMGGNGTDRGVYSYWAWTSGSGSVHSPRICLLLGGTLGALELLRP
Protein: CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein (Pathogenesis-related protein-like) (O81889)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Regulatory protein NPR1
- Isochorismate synthase 1, chloroplastic
- Defensin-like protein 16
- Pathogenesis-related protein 5
- Transcription factor MYC2
Sequence:
MFHKVAIETLVLLLLINYLTQIDVSSAQYSQYPQSHEYPDSYLRPHNAARAAVKVKPLRWDFGIATVAQDYANHLASGPCSLEHSSGPYGENLAFGSGDMSAAQAVAMWVHEKSYYDFYSNSCHGPACGHYTQVVWRGSARLGCGKAKCNNGASIVVCNYDPAGNYIGARPY
Protein: Trypsin inhibitor ClTI-1 (P85000)
Organism: Gallus gallus (Chicken)
Function: Inhibits trypsin and plasmin.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Sperm acrosome associated 1.
- Acrosin-b
- BMP/retinoic acid inducible neural specific 2
Sequence:
SIPPACDKYSRLPGCPRDYSPVCGTDGKTYPNECVLCLSNSEENKNVQIYKSGMC
Protein: GEO10024p1 (GH09956p) (InaF-B) (A8WH76)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO11103p1
- FK506-binding protein 59
- Inactivation-no-after-potential D protein
- InaF-D
- Transient receptor potential protein
- Uncharacterized protein, isoform B
- Neither inactivation nor afterpotential protein C
- Transient-receptor-potential-like protein
- Opsin Rh1
- Protein kinase C, eye isozyme
Sequence:
MSGPSALMANLADVVKEAKDEEIPMPKSNDFFESKTFRLLTLLLYMGGVSGMGLTLAVYYLFIWDSRMPPLPVFKHTHPIG
Protein: Rhino (Q49BK6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRNHQRPNLGLVDAPPNDHVEEYVVEKILGKRFVNGRPQVLVKWSGFPNENNTWEPLENVGNCMKLVSDFESEVFRLHRKAAAKSVGKSKSSPSSSGPLITENGTSSSKKTQQHSKSVQAKNTAGMSKMDQKKGKNIKKTAGKIKDIENYPKTQMPITSQVSTDSTEVFDGNPSATTTNMIKSPRIQSLFSDLNLIEPTKDKDVGDTSLKTPPKSRRLIEFPQREDAPLSSKHVSPMLIRKESQPLQSSCTDDSDLGESSSSMSLPTVSSTSSEKSIKVTKSEPKTLGQIKFSSRSSDGGHAASSLGAPKEGDIGLDLSGSDSMDSEVESMRRCPRRKRKKTYPNWKFPEITKPFGVNRGLDLDEILHCYQMNDDLFMFVTWKGCSSIDAVHINDIKEAYPLQIIKYFESLRIIVPK
Protein: 6-phosphogluconolactonase 3, chloroplastic (6PGL3) (EC 3.1.1.31) (Protein EMBRYO DEFECTIVE 2024) (Q84WW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Involved in the regulation of cellular redox state; enzymatic activity is required for this function. Required for sugar-dependent expression of nitrate assimilation genes in the nucleus of root cells.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19457984, ECO:0000269|PubMed:23621281, ECO:0000269|PubMed:24008768, ECO:0000305|PubMed:17951448}. Peroxisome {ECO:0000269|PubMed:17951448, ECO:0000269|PubMed:24008768}.
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic
- Gluconokinase
- Inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic
- Glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic
- Glucose-6-phosphate 1-dehydrogenase 5, cytoplasmic
Sequence:
MASSSCFLRSILFSSPTNLRSNHHLPTFFPKNYLICSHSTSSRFESLSVSSIGTGSTKKSSDTRRKVKSMATTNIGKEEKKRVEIYDLEENLVIDLAKFTADLSDKFCKERGAFTVVVSGGSLIKSLRKLVESPYVDSIDWARWHFFWVDERVVPKNHDDSNYKLAYDSFLSKVPIPPGNVYAINEALSAEAAADDYETCLKHLVNTNILRVSESTGFPKFDLMLLGMGPDGHVASLFPGHGLCNESKKWVVSISDSPKPPSERITFTFPVINSSAHVALVVCGSGKAEAVEAALKKTGNVPPAGSVSAEDELVWFLDKPASSKL
Protein: Protein dpy-30 homolog (Q9VZJ1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Homeobox protein goosecoid
- Boundary element associated factor
- Histone-lysine N-methyltransferase SETD1
- Retinoblastoma-binding protein 5 homolog
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Male-specific sperm protein Mst84Dc
- Cytosol aminopeptidase
- 10 kDa heat shock protein, mitochondrial
- CXXC-type zinc finger protein 1
- CXXC-type zinc finger protein 1
Sequence:
MPVSPGEGEVNGGGDVAKNDSNSQQSVDGIDAFAACQKPRPDTSSMPVRQYLDQTVAPILLHGLQALARDRPSDPISYLATYLLKNKNRCDEVKTEEN
Protein: Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) (P62166)
Organism: Homo sapiens (Human)
Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:17555535}. Postsynaptic density {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11092894, ECO:0000269|PubMed:17555535}. Cytoplasm {ECO:0000250|UniProtKB:P62168}. Cell membrane {ECO:0000269|PubMed:17555535}; Peripheral membrane protein. Membrane {ECO:0000250|UniProtKB:P62168}; Lipid-anchor {ECO:0000305}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000305, ECO:0000305|PubMed:17555535}.
Interaction partners:
- Phosphatidylinositol 4-kinase beta
- Interleukin-1 receptor accessory protein-like 1
- D
- Rhodopsin kinase GRK1
- Voltage-gated potassium channel KCNC1
- A-type voltage-gated potassium channel KCND2
- ADP-ribosylation factor 1
- Cytoplasmic tRNA 2-thiolation protein 2
- Calcium-dependent secretion activator 1
- A-type voltage-gated potassium channel KCND3
Sequence:
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
Protein: Prefoldin subunit 6 (Gene involved in microtubule biogenesis 1) (Q2HIK4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8. Required for the biogenesis of tubulins and for subsequent microtubules (MTs) organization and dynamicity, but unable to associate with microtubules. Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus. Contributes to the GA-dependent regulation of PIN2 trafficking at the plasma membrane, thus influencing auxin flux.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19004800, ECO:0000269|PubMed:23583555}. Nucleus {ECO:0000269|PubMed:23583555}. Note=In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (PubMed:23583555). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (PubMed:23583555). This changing subcellular localization follows a daily rhythm coordinated oscillation (PubMed:23583555). {ECO:0000269|PubMed:23583555}.
Interaction partners:
- Prefoldin subunit 3
- Prefoldin subunit 5
- Prefoldin subunit 1
- Prefoldin subunit 4
- Prefoldin subunit 2
- Prefoldin chaperone subunit family protein
- Prefoldin chaperone subunit family protein
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit delta
Sequence:
MSSSTVRDLQRDLENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAILQDMEEKQNNKRETIMKLQQRLQTIQAGKAKA
Protein: Podocan-like protein 1 (Q6P3Y9)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21672516}.
Interaction partners:
Sequence:
MRPQELLLLLLMLKWSLAHTEDPAFPHLGDSSQPLPRPCPWRCSCPRDDTVDCAGLDLRIFPDNITRAARHLSLQNNQLRELPYNELSRLSGLRTLDLHSNLITSEGLPDEAFESLNQLENFYVAHNKLSVAPQFLPRSLRVADLAANEVVEIFPLTFGEKPALRSVYLHNNRLRNTGLPPNTFHGSEVITTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRGALSLQTHLRELYLQHNQLTDSGLDATTFSKLSSLEYLDLSHNQLATVPEGLPGTLTILHLGRNCIRHVEAVRLHKARGLRYLLLQHNKLGASALPKGTLRPLRALHTLHLYGNKLERVPPALPRHLQALVMPHNHVAALGARDLVSARALAELNLAYNSLASAHVHPSAFRRLRALRSLDLAGNQLTRLPEGLPASLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRVGDIGPGTWHELQALKVLDLSHNELSFVPPDLPEALEELYLQANRISHVGPEAFLSTPHLRALFLRANRLHMTSIRAEALQGLTHLRVVDTAENPEQVLV
Protein: Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) (P43354)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23283970}. Nucleus {ECO:0000269|PubMed:17184956, ECO:0000269|PubMed:23283970}. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. {ECO:0000269|PubMed:23283970}.
Interaction partners:
- Pituitary homeobox 3
- Period circadian protein homolog 2
- Protein FosB
- LIM homeobox transcription factor 1-alpha
- Nuclear receptor subfamily 4 group A member 3
- Tyrosine 3-monooxygenase
- Early growth response protein 1
- Synaptic vesicular amine transporter
- Sodium-dependent dopamine transporter
- Protein c-Fos
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
Protein: Myosin-1 (Class I unconventional myosin) (Type I myosin) (Q9Y7Z8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:11076964, ECO:0000269|PubMed:16051179, ECO:0000269|PubMed:16087707}. Note=Localizes to cortical patches at the tips of growing cells and at sites of cell division.
Interaction partners:
- Actin-binding protein wsp1
- Calmodulin
- Myosin 1 light chain cam2
- Verprolin
- Actin
- Protein BZZ1
- Fimbrin
- Myosin regulatory light chain cdc4
- Ring assembly protein 3
- Cell division control protein 15
Sequence:
MAILKRTNRAKAATAAAPNSTGKSNGIKKAVYTSTRKKTVGVDDLTLLSKITDEEINKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQGKNRLETSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHVSKSVGTEIERVSEIILATNPLLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNERNFHIFYQFTKSAPQKYRDTYGIQGPENYVYTSACQCLSVDGISDEKDFQGTMNAMKVIGITEPEQDEIFRMLSIILWLGNIQFQEGQDGGSVISDKSITEFLGYLIGVPVAAIERALTIRIMQTQHGARRGSVYEVPLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNSVSNSIGILDIYGFEIFENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNKVVCDLIESKRPPGLFAAMNDAIATAHADSAAADSAFAQRLNFLSSNPHFEQRQNQFIVKHYAGDVTYSITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESNSRRRPPTAGDRIKTSANDLVETLMKCQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQRFAVLSGKTSYAGEYTWQGDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETLFALEDMRDKFWDTMATRIQRAWRSYVRRRSEAAACIQKLWNRNKVNMELERVRNEGTKLLQGKKQRRRYSILGSRKFYGDYLSASKPNGTLWNTCGLSQNDHVIFSMRCEVLVHKLGRTSKPSPRQLVLTKKNLYLVITKIVDQKLTQQVEKKFAVSSIDSVGLTNLQDDWVAIRNKSSQNGDMFLRCFFKTEFITTLKRINRNIQVIVGPTIQYCRKPGKVQTVKTAKDETTKDYDYYKSGTIHVGTGLPPTSKSKPFPRLATGGSTAAARGPRPVVQNKPAATKPVSMPAAKSKPAPMANPVSTAQQTQNRPPAPAMQARPNTTQAAAPVTSTTTTIKQATTVSASKPAPSTVTSAASSPSNISKPSAPVANNVSKPSAVPPPPPPPPAEVEKKDLYLALYDFAGRSPNEMTIKKDEIIEIVQKEPSGWWLALKNGAEGWVPATYVTEYKGSTPQTTASSTNVAAQANNNASPAEVNNLAGSLADALRMRASAVRGSDEEEDW
Protein: Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1) (P70503)
Organism: Rattus norvegicus (Rat)
Function: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P51843}. Cytoplasm {ECO:0000250|UniProtKB:P51843}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus. {ECO:0000250|UniProtKB:P51843}.
Interaction partners:
- Steroidogenic factor 1
- Nuclear receptor subfamily 5 group A member 2
- Homeobox protein NANOG
- Steroid hormone receptor ERR2
- Sal-like protein 4
- Nuclear receptor corepressor 2
- Transcription factor CP2-like 1
- Transcription factor GATA-4
- POU domain protein
- Steroidogenic acute regulatory protein, mitochondrial
Sequence:
MAGEDHPWHGSILYNLLMSAKQKHGSREEREVRLGAQCWGCACGTQPVLGGEGLPGGQALSLLYRCCFCGENHPRQGGILYSMLTNARQPSGATEAPRARFRTPCWGCACSNAKPLVGRXGLPAGQVPSLLYRCCFCGKKHPRQGSILYSLLTNAQQTHVSREVPEAHRGGEWWQLSYCTHNVGGPEGLQSTQAMAFLYRSYVCCEEQPQQSSVASDTPVRADQTPAAPQEQPRAPWWDTSSGVQRPIALKDPQVVCEAASAGLLKTLRFVKYLPCFQILPLDQQLVLVRSCWAPLLMLELAQDHLHFEMMEISEPNLMHEMLTTRRQETEGPEPADPQATEQPQTVSAEAGHVLSVAAVQAIKSFFFKCWSLNIDTKEYAYLKGTVLFNPDLPGLQCVKYIESLQWRTQQILTEHIRLMQREYQIRSAELNSALFLLRFINTDVVTELFFRPIIGAVSMDDMMLEMLCAKL
Protein: Testis-specific transporter TST-2 (Q8K4K9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGQVQNKKPDAKKDDKHNQETEGLKKIDTYLRTIPTVTKKFKGRPQKKRSPTSAELLLDPKYSASKEGPFGLGPLVFPCLQRFNNIDCFMIFFIASVLIHGALFALADMILNLYHSLLTLSKRELYFMDFSGYIVSSLVAIFVAHFGGKGNRTKWIAAACILMAFGSILLGFPFSKYEIMKSGGQRVELCVEENKRRNIHCVTNSNPDRTKCICFFIIGQCLNGIAGMPIYILGKTFILDHVPTRSAGFYLALGHSAHLMGYFLGIFGGMKNLSPPPKEKLSAVDSAKIHLLLQFGWWKTFLFVAAISFSVFLVLLCFPTSLPGAHKLKLAKRKEPPTFDKRLKDQKIQPRFKGFVFAIWYMLRNPLLMTQAMCKVSESFAFHTSLEFLPYHLQTQFSITPQIASMLTGLFVIPGGVIGHFLGGLIVDRLEMTNKNKLKFSLVTSVVSVALFLLIFFVECETTKFAGINEDYDGLGKLGNLTAGCNYHCACTTSLYSSVCGRDEKEYFSPCFAGCSATKVQQNEKTYYNCSCIKEGLTTSDADGHFIDATDGTCNSNCLTLPLFFAFYFSATVFSTMCSTPIILIILQSVPANFSSLGQGVTVAITKFTASVPEPALFGTASSVACKFWDINACGVREKCWIYNKTTLVYVFIGIWVSFKLFTALLNIYAIHIYDYVVKGKISDSKTTHVKASKAQKERRA
Protein: Ras-related protein Rab-35 (EC 3.6.5.2) (Q6PHN9)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q15286}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q15286}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q15286}. Endosome {ECO:0000250|UniProtKB:Q15286}. Melanosome {ECO:0000250|UniProtKB:Q15286}. Note=Present on sorting endosomes and recycling endosome tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified in stage I to stage IV melanosomes. {ECO:0000250|UniProtKB:Q15286}.
Interaction partners:
- DENN domain-containing protein 1B
- DENN domain-containing protein 1A
- Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
- TBC1 domain family member 10A
- Inositol polyphosphate 5-phosphatase OCRL
- DENN domain-containing protein 1C
- AP-4 complex accessory subunit RUSC2
- TBC1 domain family member 10B
- TBC1 domain family member 24
- Tumor susceptibility gene 101 protein
Sequence:
MARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCDDVCRILVGNKNDDPERKVVETEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDNLAKQQQQQQNDVVKLTKNSKRKKRCC