wanglab/gogpt-training-data huggingface dataset:
Protein: GH01922p (Q7K5N5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPKNGGAGHRNTAPRKRQIPAAQLDEDSPIVQQFRIYSNELIMKHDRHERIVKLSRDITIESKRIIFLLHSIDSRKQNKEKVLEEARQRLNKLIAVNFRAVALELRDQDVYQFRSSYSPGLQEFIEAYTYMEYLCHEDAEGENETKSVSDWQAIQAVMQYVEESSQPKEEPTEGEDVQAIAQVESPKKFQFFVDPTEYILGLSDLTGELMRRCINSLGSGDTDTCLDTCKALQHFYSGLVSSPLRNSINFLLFSVTSV
Protein: Uncharacterized protein (Q381K6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cytochrome c
Sequence:
MSKPTRKSVSERNQSESSALRPSISPSTRWNDSVDRGSSCSSIRIDYQRLMDSHTRRAEVIAQYRQLVMNRRSQNGQGEPTVCDEERSDWLREDEWDRLFSLEEERCSCINGEQEPPLREEGEVILKQKEEVEEDRELRAKEEEEDRKRKQREEEERKRKQREEEEEDRKRKQREEEEDRKRKQREEEERKRKQKEEEEEWKRRQREEDKRRNRPKDEVELKVQVEQEEERMLRLTEEVKRELHLKEEMDLQLRLQQEEGQEPELRGEEEHNRQSQSAVPRRTMSAESDNRSVSPRTTATSRASAQLASGAAVMSSLRSSSPSSWRASHGGISMLPMSVVAMKKPSEQHPLESSRRREGENSGSTRVRQSLVYPLVSPTTATLSPVTNPSARANSRSEKHPGDTPDSVISTSKQSTAHNSKVAVREENNVEKPAAKASVSSSTHKRAPTPTSVAKSSTKRSGTMSSETKSSTKRSTHGGKEQSELQPRSQQNIKQRQQAIREVEDPSLLTSATAHTIKVSTPSREGPRSQAVAADAVDGACHSISNESSSRQSEWAPRLPTTVHEPAPQAKSRDGKMGSEAPRVDPEDAFHASKFDTRTVSTNLSSVLPARAPAGSTMEEELLLLLRESQKGVSSSTEPSVRVSPTRRSTVFGTQTNRGSCIASAAAVLQGMLRRSREVVPCYYCGEMQPLKTYSLHLDFCRTKTTALYRRYGLSTLRLNMGIPTRCIPEAVSEATREELDAFTRACYECVKVSIIPCPGCGTHMRVHDLPEHAEACKSGANSGRRTTVSSKS
Protein: Protein CUP-SHAPED COTYLEDON 3 (NAC domain-containing protein 31) (ANAC031) (NAC domain-containing protein CUC3) (Q9S851)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for axillary meristem initiation and separation of the meristem from the main stem. May act as an inhibitor of cell division.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TCP4
- Transcription factor MYB117
- Homeobox protein knotted-1-like 6
- Homeobox protein knotted-1-like 1
- B3 domain-containing protein At5g06250
- Homeobox protein knotted-1-like 2
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 3
- Transcription factor MYB105
- Protein ASYMMETRIC LEAVES 2
- Transcription factor AS1
Sequence:
MMLAVEDVLSELAGEERNERGLPPGFRFHPTDEELITFYLASKIFHGGLSGIHISEVDLNRCEPWELPEMAKMGEREWYFYSLRDRKYPTGLRTNRATTAGYWKATGKDKEVFSGGGGQLVGMKKTLVFYKGRAPRGLKTKWVMHEYRLENDHSHRHTCKEEWVICRVFNKTGDRKNVGLIHNQISYLHNHSLSTTHHHHHEALPLLIEPSNKTLTNFPSLLYDDPHQNYNNNNFLHGSSGHNIDELKALINPVVSQLNGIIFPSGNNNNDEDDFDFNLGVKTEQSSNGNEIDVRDYLENPLFQEASYGLLGFSSSPGPLHMLLDSPCPLGFQL
Protein: Alpha N-terminal protein methyltransferase 1 (EC 2.1.1.244) (X-Pro-Lys N-terminal protein methyltransferase 1) (NTM1) (Q6NN40)
Organism: Drosophila melanogaster (Fruit fly)
Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).
Interaction partners:
- type I protein arginine methyltransferase
- Protein crossbronx-like
Sequence:
MTTTLEEQLSDKLQMMDETTDKVQGSSKQKDDSSIAASSDAKTASPSSSDSSTKVAAPESEFYNKAQKYWSEVPATVNGMLGGLGYISAIDIQGSNVFLREIRVPGNRLALDCGAGIGRVTRNLLIPRFSCVDLVEQDPAFADKAREYCTSEDGSRGKVGQIYNVGLQKFTPTQQYDLVWTQWVLGHLTDRDLVSFFRRIKQGLAPGAFLCLKENVSSSKKTVEDRNDSSVTRPLDSYEHFLKEAGFRIVRKVKQQNFPKGLFPVYMIACKPVSKE
Protein: Antitoxin VapB11 (P9WLU3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin VapC11.
Interaction partners:
- Ribonuclease VapC11
- Ribonuclease VapC15
- NAD-dependent protein deacylase
- Uncharacterized HTH-type transcriptional regulator Rv1395
- Antitoxin ParD1
- site-specific DNA-methyltransferase
- Possible transcriptional regulatory protein
Sequence:
MYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD
Protein: [Thr6]-bradykinin [Cleaved into: Des-Arg9-[Thr6]-bradykinin] (C0HKA8)
Organism: Physalaemus nattereri (Cuyaba dwarf frog) (Eupemphix nattereri)
Function: Thr6-bradykinin: Induces relaxation of rat smooth muscle from tail artery and contraction of that from ileum, urinary bladder and uterus. Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2).
Subcellular location: Secreted {ECO:0000269|PubMed:26443407}.
Interaction partners:
Sequence:
RPPGFTPFR
Protein: Autocrine motility factor receptor (R4GNG2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
YLATSGYPWPAWSSLCSCVTCFMRCNVEFVGTRTIYVWLETWRPGLQLQLQRSWLSTMTTVPSVGTPCRLRGNCPVDIFSTRSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
Protein: Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) (Q9H0H3)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis. BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells.
Interaction partners:
- Cullin-3
- Ectoderm-neural cortex protein 1
- Kelch repeat and BTB domain-containing protein 8
- Kelch-like protein 21
- Kelch-like protein 13
- Kelch-like protein 9
- Kelch-like protein 42
- Gigaxonin
- E3 ubiquitin-protein ligase RBX1
- Kelch-like protein 22
Sequence:
MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
Protein: Trafficking protein particle complex subunit 3-like protein (TRAPPC3-like protein) (BET3-like protein) (Q5T215)
Organism: Homo sapiens (Human)
Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 9
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 12
- Trafficking protein particle complex subunit 1
Sequence:
MSRPAHRRPEYHKINKDLFVLTYGALVAQLCKDYEKDEDVNQYLDKMGYGIGTRLVEDFLARSCVGRCHSYSEIIDIIAQVAFKMYLGITPSVTCNNSSKNEFSLILEKNPLVEFVEELPAGRSSLCYCNLLCGIIRGALEMVHLAADVTFLQDRLKGDSVTEIGITFLKKRDEKKYRGKK
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q7K3T4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Putative inositol monophosphatase 3
- Estrogen-related receptor splice variant
Sequence:
MNYSYSALSPGGSGGFGGVDQHNRCCGNKAWCVKDICGIVCVIMTWLLILFAEFVVMRLILLPSNYTVFSTINMIIFQALAFLAFASHIRTMLSDPGAVPRGNATKEMIEQMGYREGQMFYKCPKCCSIKPERAHHCSVCQRCIRKMDHHCPWVNNCVGENNQKYFVLFTFYIASISVHTLFLVLTQFAECVKNDWRTCSPYSPPATIFLLLFLTFEGLMFGIFTIIMLATQLTAILNDQTGIEQLKKEEARWAKKSRLKSIQSVFGRFSLAWFSPFTEPSCRTRFNSHFYSV
Protein: Protein DETOXIFICATION 12 (AtDTX12) (Multidrug and toxic compound extrusion protein 12) (MATE protein 12) (Q8L731)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGDAESTKDRLLLPVERVENVTWSDLRDGSFTVELKRLIFFAAPMAAVVIAQFMLQIVSMMMVGHLGNLSLASASLASSFCNVTGFSFIIGLSCALDTLSGQAYGAKLYRKLGVQTYTAMFCLALVCLPLSLIWFNMEKLLLILGQDPSIAHEAGKYATWLIPGLFAYAVLQPLTRYFQNQSLITPLLITSYVVFCIHVPLCWFLVYNSGLGNLGGALAISLSNWLYAIFLGSFMYYSSACSETRAPLSMEIFDGIGEFFKYALPSAAMICLEWWSYELIILLSGLLPNPQLETSVLSVCLQTISTMYSIPLAIAAAASTRISNELGAGNSRAAHIVVYAAMSLAVIDALIVSMSLLIGRNLFGHIFSSDKETIDYVAKMAPLVSISLMLDALQGVLSGIARGCGWQHIGAYINLGAFYLWGIPIAASLAFWIHLKGVGLWIGIQAGAVLQTLLLALVTGCTNWESQADKARNRMALAYGT
Protein: Neuropeptide receptor npr-1 (Neuropeptide Y receptor homolog npr-1) (Q18534)
Organism: Caenorhabditis elegans
Function: G-protein coupled receptor for FARP(FMRFamide related peptide) neuropeptides. Activated by FARP neuropeptides flp-18 and flp-21. Plays a role in modulating social and feeding behavior. Required to modulate locomotion quiescence during the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FMRFamide-like neuropeptide 21
- FMRFamide-like neuropeptide 18
- Globin domain-containing protein
- Soluble guanylate cyclase gcy-35
- Soluble guanylate cyclase gcy-36
- Cyclic nucleotide-gated channel
- Soluble guanylate cyclase gcy-32
- G-protein coupled receptors family 1 profile domain-containing protein
- Dauer larva development regulatory growth factor daf-7
- Cyclic nucleotide-binding domain-containing protein
Sequence:
MEVENFTDCQVYWKVYPDPSQSIYAIVPFLTVYLFLFFLGLFGNVTLIYVTCSHKALLSVQNIFILNLAASDCMMCILSLPITPITNVYKNWYFGNLLCHLIPCIQGISIFVCTFSLGAIALDRYILVVRPHSTPLSQRGAFLTTVLLWILSFVVTLPYAFNMQMIEYTEERICGYFCTEKWESAKSRRAYTMIVMLAQFVVPFAVMAFCYANIVSVLSKRAQTKIRKMVERTSALESSCAFPSHGLEQYENELNEFLDKQEKEKQRVVLQNRRTTSILVTMVVWFGITWLPHNVISLIIEYDDTQSFFRLYGRDDYDISYLLNLFTHSIAMSNNVLNPVLYAWLNPSFRQLVIKTYFGDRRKSDRIINQTSVYKTKIVHDTKHLNGRAKIGGGGSHEALKERELNSCSENLSYHVNGHTRTPTPEVQLNEVSSPEISKLVAEPEELIEFSVNDTLV
Protein: Colicin V production protein (Protein DedE) (Pur regulon 18 kDa protein) (P08550)
Organism: Escherichia coli (strain K12)
Function: Required for colicin V production from plasmid IncFI ColV3-K30.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Amidophosphoribosyltransferase
- Phosphoribosylformylglycinamidine synthase
- Phosphoribosylformylglycinamidine cyclo-ligase
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Formate-dependent phosphoribosylglycinamide formyltransferase
- N5-carboxyaminoimidazole ribonucleotide mutase
- Phosphoribosylglycinamide formyltransferase
- Bifunctional purine biosynthesis protein PurH
- N5-carboxyaminoimidazole ribonucleotide synthase
- Cell division protein DedD
Sequence:
MVWIDYAIIAVIAFSSLVSLIRGFVREALSLVTWGCAFFVASHYYTYLSVWFTGFEDELVRNGIAIAVLFIATLIVGAIVNFVIGQLVEKTGLSGTDRVLGVCFGALRGVLIVAAILFFLDSFTGVSKSEDWSKSQLIPQFSFIIRCFFDYLQSSSSFLPRA
Protein: At4g36090 (Oxidoreductase, 2OG-Fe(II) oxygenase family protein) (Q5RJC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- N6-adenosine-methyltransferase non-catalytic subunit MTB
- Protein virilizer homolog
- Ornithine transcarbamylase, chloroplastic
- YTH domain-containing protein ECT4
- YTH domain-containing protein ECT3
Sequence:
MEPNYEEDVFLAKYQSSELKIASEFLTNWLPFLSRDLCNDCAHVLSDRIRSLDPEHCSNGEVKAGSGSMVDNMESEEVDNMESEEVDNKMDNIYDGKLCVSHSLDSLKAGAFVFGSLSDSVSHAMPSSQSTVSEAASAQMSWADMGEEDGLEEEDQKENELGSHGVDVSPSVGDSMKTPEKRKLSREERERYRFMNVKKMKVFSCYEKVRGRSVNILEGLELHTGVFSAVEQKKIVDFVYELQEKGRRGELRERTFTAPHKWMRGKGRVTIQFGCCYNYAPDKAGNPPGILQRGDVDPMPSIFKVIIKRLVGWHVLPPTCVPDSCIVNIYEEDDCIPPHIDNHDFLRPFCTVSFLSECNILFGSNLKVLGPGEFSGSYSIPLPVGSVLVLKGNGADVAKHCVPAVPTKRISITFRKMDESKRPVGFTPEPDLEEIKPLPYEHTTPSTPADAVISSSRSSIDQNGSNHNNRTAHGGGSKYRRSRDYHSESRERSSSGQRRETSRHTPNRSYRPKVTSSDNV
Protein: Probable coatomer subunit zeta (Zeta-coat protein) (Zeta-COP) (O74891)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit beta
- Coatomer subunit delta
- Probable coatomer subunit beta'
- Probable coatomer subunit gamma
- Probable coatomer subunit epsilon
- Putative coatomer subunit alpha
- ADP-ribosylation factor 1
- ADP-ribosylation factor GTPase-activating protein glo3
- Ribosome quality control complex subunit 2
- Protein rer1
Sequence:
MNLTLYAVNAFLILDSSGKRIFTKYYAPPHLKEGEGGVFNSVKEEKTFEKGLFEKTWKTQNDILTYDGKLVVMLTVMDVIFYIVGGMEENEVMLYECLRSIRDALELLFKYVPDKRTLLENYDQLVIVVDETIDDGVILETEPALIAARVTKGPVSEAQAIVSDFKEMGFMNSFQKAREKITERILKGTF
Protein: Defensin-like SRCA-homolog protein (S locus cysteine-rich-like protein 37) (AlSCR37) (C0LQF3)
Organism: Arabidopsis lyrata (Lyre-leaved rock-cress) (Arabis lyrata)
Function: Involved in male-mediated self-incompatibility.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MRCVVLFMVSCLLIVLLINHFEEVEAQKWKECNLRDIFPGKCEHDANAKLRCKEDIAKNFRPSRPFECDCQTFDQGRICYCKKCLV
Protein: Sororin (Cell division cycle-associated protein 5-A) (Xp35) (Q563C3)
Organism: Xenopus laevis (African clawed frog)
Function: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of wapl which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:21059905}. Chromosome {ECO:0000269|PubMed:21059905}. Cytoplasm {ECO:0000269|PubMed:21059905}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
Interaction partners:
Sequence:
MSEGKKRSRGGLAIISPPKRRSQRKSTSDSPIPEPIMKRSITVKKIMPRKTLAAIVNTGSQSTPKVSNVPPAPRRSSRISPKIQKENAFSEQSQIVHKDVPGQSSAPKINVLSPIPVNIQLSPKQDNRDIIMSQKVRRSYSRLEMSLNSSSSLYSPTRKTDSSDTSTPNVVLKSGRSSLFGFDKLLNSEMPDGELKKSNGVTRKKNTKERILGTVLPEQPDHNIPGVVLAKQKRRKRKVAIIEKSDLDEWAAFMNAEFEEAEKFDLTVE
Protein: Kelch domain containing 3 (F8W6A4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPKGPAMCSMPLTSADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (F4IIK4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEDSLRVGMISSGLAVLLNGEDAKENSSKARIVPHFDYSGHRPLERTIEFIFGLAEKSVGPLDGQVDSSLIRAVIKNQFSKLHGDLDVSVSQREGISVVHHGVGPPIVGLEEFSICGDIRIVKPPLVLESLALFSSARANACIWKGKWMYEVALETSGIQQLGWATLACPFTDQKGVGDADDSYAFDGRRVSKWNKEAEPYGQSWVAGDVIGCCIDLNCDEIYFYRNGVSLGAAFTGIRKLGPGFGYYPAISLSQGERCELNFGAYPFKYPVDGFQPLQEAPTRFSFATELLRCFSRLLDRPDRSLADTLSRLRRFASVEELFCPVSSAICDEFFYILEQDPLLAEYLGRGAFLSFLLETFRTQAPHDSSSLDKVLDVFLEFPQSHLIFEHVVNALACGCKTATLILTECPYSGPYPYLALACHLFKREELMVQWWRSLHFEFLFEGFLSCRSSNKHDLQHLMPVVWWPGSSEDISYESSMGFTISALSEAINKIEEKQRNLCLLVIQFIPPVSPPQLPGSAFRGFLQNLLLKNRGADRTLAPSGVTRNSVLVSLFSVILHFLSEGFAMLKSSEAVHHNVGFLHRGGQQKFPLSLFLKNDPHRADITRLGGLFSHISKSYPTDDQEEEIMRWEEGCMDDEQNRVTHATEQKPCCCLAYDTDLTKSLKDRGKNTAQSSRGRCSSIPERSSHVAAECSAGSFSEEIDDKPSTSNQSDPDFGYRPVRFMRTALQESRISSAILSEEELLDALLLLYHIAVAPNFKQASYYMSHQSQSISLLEETDKQIRERASCDQIKRLKEARNNYKEDVMDCVRHSAWFRISLFSRWKQRGMYALCMWVVQLLLVLSKMDSVFVYIPEFYLESLVDCFHVLRKSDPPFVPSTTFIKQGLSSFITFVVTHFNDSRISNTDLKDLLLQSISVLVQYKEYLEAFENNEAATRHMPAALLAAFDNRSWIPVTNIFLRLCKGSGFSSLKNGESSFSSTVFQALLRDACINDGELLSTFLNRLFNTLSWTITEFSVSVREMQEKYQVMEFQQRKCCVIFELSSNLARVLEFCTYAMPQAFLAGTDTNLRRLTELILFILNHMTSAVDDEFFDLSVRSLRRQGQPSEKVSRGILLAPLVGIILNLLEASEDSKPKQQHDVIGLFASMDCPDTVYYGFQYLLEYNWDGCVSGDDAYVKKLGQLENFLSHLINRASSQEPERKEESFNKDTTDIEDNTCCICYAGEANAMIAPCSHRSCYGCITRHLLNCQRCFFCNATVIDVIRDKEEEEEEDDDGHKRST
Protein: Mce-family protein Mce1B (O07414)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Mce-family protein Mce1F
- Mce-family protein Mce1A
- Conserved integral membrane protein YrbE1A
- Conserved integral membrane protein YrbE1B
- Mce-family protein Mce1D
- Possible Mce-family lipoprotein LprK
- Mce-family protein Mce1C
- Probable ribonucleotide transport ATP-binding protein mkl
- Mce-family protein Mce2A
- Mce-family protein Mce3A
Sequence:
MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYSDLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVFRALDPAKVNNIANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEVVKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNGAGTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQPTGRCTPQ
Protein: ATPase asna-1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (P30632)
Organism: Caenorhabditis elegans
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03112}. Endoplasmic reticulum {ECO:0000255|HAMAP-Rule:MF_03112}.
Interaction partners:
- Guided entry of tail-anchored proteins factor 1
- Conserved Edge Expressed protein
- UV excision repair protein RAD23
- SGTA homodimerisation domain-containing protein
- Probable Golgi transport protein 1
- Putative syntaxin-5
- Uncharacterized protein
- Probable FAD synthase
- Peroxisomal ATPase PEX1
- Translocon Sec61/SecY plug domain-containing protein
Sequence:
MSDQLEASIKNILEQKTLKWIFVGGKGGVGKTTCSCSLAAQLSKVRERVLLISTDPAHNISDAFSQKFTKTPTLVEGFKNLFAMEIDSNPNGEGVEMGNIEEMLQNAAQNEGGSGGFSMGKDFLQSFAGGLPGIDEAMSFGEMIKLIDSLDFDVVVFDTAPTGHTLRLLQFPTLLEKVFTKILSLQGMFGPMMNQFGGMFGMGGGSMNEMIEKMTTTLESVKKMNAQFKDPNCTTFVCVCIAEFLSLYETERLIQELSKQGIDTHNIIVNQLLFPDTDANGTVSCRKCASRQAIQSKYLTDIDELYEDFHVVKLPLLEAEVRGGPAILQFSERMVDPEANKN
Protein: Delta-6 fatty acyl desaturase (Delta-6 fatty acyl desaturase-like isoform X1) (D2KE03)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Retinoic acid receptor responder protein 3
- Retinoic acid receptor responder protein 3
- HRAS-like suppressor 3
- HRAS-like suppressor 3
- Elongation of very long chain fatty acids protein 5
- Elongation of very long chain fatty acids protein 2
Sequence:
MGGGGQQTESSEPAKGGVVGPGGGRGGRGGSAVYTWEEVQRHCHRGDQWLVIDRKVYNITQWAKRHPGGIRVISHFAGEDATDAFSAFHPDPNFVRKFLKPLLIGELAPTEPSQDQGKNAALVQDFQALRDRVEREGLLRARLLFFSLYLGHILLLEALALGLLWVWGTSWSLTLLCSLMLATSQAQASWLQHDFGHLSVFKKSSWNHVLQKFVIGHLKGASANWWNHRHFQHHAKPNVFRKDPDINSLHVFVLGDTQPVEYGIKKLKYMPYHHQHQYFFLIGPPLLIPVYFHIQILRTMFLRQDWVDLAWSMSFYLRFFCCYYPFFGFFGSVALISFVRFLESHWFVWVTQMNHLPMEMDHERHQDWLTMQLSATCNIEQSTFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPLVRTLCEKHGVPYQVKTLKKGIIDVVRSLKKSGDLWLDAYLHK
Protein: Zinc finger X-chromosomal protein (P17012)
Organism: Mus musculus (Mouse)
Function: Probable transcriptional activator.
Subcellular location: Nucleus.
Interaction partners:
- N-myc proto-oncogene protein
- Myc proto-oncogene protein
- Transcription factor E2F1
Sequence:
MDEDGLELQQQAPNSFFDATGAGATHMDGNQIVVEVQETVYVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVGHVEHVVHDSVVEAEIVTDPLAADVVSEEVLVADCASEAVIDANGIPVNQQDEEKNNCEDYLMISLDDAGKIEHDGSSGLTMDNETEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENEHGVELLDPNNSIRVPREKMVYMAVNDSQQEEEELNVAEIADEVYMEVIVGEEDAAAAAAAAVHEQQVEDNEMKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQSELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP
Protein: Copine-1 (Copine I) (Q8C166)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q99829}. Cytoplasm {ECO:0000250|UniProtKB:Q99829}. Cell membrane {ECO:0000250|UniProtKB:Q99829}. Note=Translocates to the cell membrane in a calcium-dependent manner. {ECO:0000250|UniProtKB:Q99829}.
Interaction partners:
Sequence:
MAHCVTLVQLSVSCEHLIDKDIGSKSDPLCVLLQDVGGAWAELCRTERVRNCSSPEFSKTLQIEYHFETVQKLRFGIYDIDNKTPELGDDDFLGGAECSLGQIVSSQTLTLPLMLKPGKPAGRGTITVSAQELKDSRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWQLAYRTEVVKNNLNPTWKRFSVSLQHFCGGDLSTPIQVRCSDYDSDGSHDLIGTFHTTLAQLQAVPAEFECVHPEKQQRKKNYRNSGTVRVKTCRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLTALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAQQRSASQYFVLLLLTDGAVTDVEATCKAVVDASKLPMSVIIVGVGGADFEVMEQLDADGGPLRTRSGEAAARDIVQFVPYRRFQNAPRETLAQTVLAEVPTQMVSYFRAQGWAPLKAPPTPGKGPAQAPQA