wanglab/gogpt-training-data huggingface dataset:
Protein: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) (Q96I99)
Organism: Homo sapiens (Human)
Function: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03221}.
Interaction partners:
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Guanine nucleotide-binding protein G
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Methylmalonyl-CoA mutase, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
Sequence:
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK
Protein: Preprofallaxidin-7 [Cleaved into: Fallaxidin-1.1; Fallaxidin-1.2; Fallaxidin-1.3; Fallaxidin-3.3] (B5LUQ9)
Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)
Function: Fallaxidin-1.1 shows no antibacterial activity against Gram-positive or Gram-negative bacteria. Does not inhibit the formation of NO by neuronal nitric oxide synthase. Has no effect on splenocyte proliferation or smooth muscle contraction.
Subcellular location: Secreted {ECO:0000269|PubMed:18803332}.
Interaction partners:
Sequence:
MASLKKSFFLVLFLGLVSLSMCEEKKRENEDDAEDGNHEEESEEKRGLVDFAKHVIGIASKLGKRSEEKRYHPFGKRSEEKRYFPIPFGKRSEEKRYFPIPIGKRSEEKRYFPIPIGKRSEEKRYFPIPIGK
Protein: RNase III domain-containing protein (Q57XF2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Argonaute-like protein
Sequence:
MDEVGALTVQDVLTVWLCDLPLKTTLKDALSGVTQLTGEENINQILRFHPPHASALTQSGECKGMLSLVGEKIIKAVASQYALLSFPVGDTYKLTNATRVLISNETFGTVLKQYTGPTFGEREMFTRFLALSLYGHGVRVACMLLLPVFRATLLANQYAIDLPAVLNSLVPCASFSRRNLGEKLEMLRGELEKRGVVVKRVVESGPCGWGGCERYTVEVLYGGELSRCEKGKVLSEFYHIVMEEAKKTIANTEVKKPRTVTFEPEHLKMWMHNLRFLLRLSDRYRDEFDDNTLQSIKQSAGWIPISEVQQLLEAQVTRSNRQQPPGRDWICELVKRHDLLGRFQVGTCDVEGSEFEGLQCARALYGHEGRNLLMKSVFDSFSTIRDPGGRPSTGWMRIDGKRMKLVSKDKGYSLHDSIPHVTIHSTESLHAFQWYRLKKPLEEQYDEILSSRKPLYFAEFRLHDALNDDRMLVRELKGIGAVPPQWVVFTEHNRDDDHQRSTLVIPENYFTGKVAVLCTNAEDVATEGMIDTKDRQTPEDEELLIVYKTWLLSADTQNSGDSKDGEENLSPRHRLPAHHTSTGATSSDDKGTTSVGAHDCVVMDQAEQPSVPTADYMEMLLDEEKRKIELFENTNTYATFVAFPKYNLHGAQIQNRSKGIAAFKTWIQERGLKYSRWRTGENDQEETYEVRKPRNWSAEFVECIAGELGLTHMPDKTLLKWATTRECEDKEQNYEILEFIGDAIMDFIVVSDSFLLGEPWHKDVNTKLCCNEVLATLIPPGLSEELSRVYDEVHYKVKADMVESILGAVYQSGMGLDEVRKQLRRFFRWIPDIIMDVKNLCNSTVEALRAAERVCPYLHPNEEALDQLFKYDCESLIDEEFFSMFGCVDRKRFDARGASHYALTPFHRIQDKMFATHFTTGSCYSYRYVPSIDTPSIFNRILSAFSAGSIAFVNELVTEDTHVTIDFDGASVHAHGALRLIWSWFIGKFPSKSSMFLLDCSGMSVVTNRLKYSYHIHFPQAVTTLSKSKSLVEELQSYVVKCVGAGSLLGDIVGFHWKEGEGNQEREAAVAGRVILCTKLLHQRLREAGGRVDAKFSAYMDLQSILALGRTCREIRHATLSYLCEKLHPKEPWGFVVMGWSRHPVGQTSEREPQFVLVRTLWASQQEKDYIGTLILFPTESLSDTTDETSSVWKAVVRKVKEKECKPKEFFLEVVKSSREQCIFSSAYWERVIDSSLHSSRKLRMYLNDKFDVKYGQEFRPLFLERLVNSSQEVRTVTPKESNVSRFVRSQEMKASAKDNGEEEYPVEVAHGSTLRLVSLRCPGYRDVYGKLWNAWSVGNNSDDTFVSIELGTPVDDLLPVFGAEYKEDEILSTEWTRFVEGAFGLQPSVETLGGGSSEQKTAALQPAYWIYDPKLGQANFCIAGEVAFFIRPCTCLLEGLTTQGGMKQMVQYIVPTVKLEDLPTREWMRSYPSNCFPLFLAPRKGSCFQPAGEPHPVVASNDGQTITVQAPVTAAAVTRVRSKVIEVTLNSSTQRPVDFEQLYKAMDDVFSGSYGPSLFVTSDMAIFSVLLDRFPCVVTPDYFKSSVSEDYTIHNGRTFHYIFIMDNACDHYQHTKVSTGLLELLDKEVGMILVTSATIQKFFRTNR
Protein: Endoprotease aex-5 (EC 3.4.21.-) (Subtilisin-like protease) (P91863)
Organism: Caenorhabditis elegans
Function: Probable serine endoprotease which cleaves preproteins at paired basic amino acids. May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cells and therefore regulates the levels of triglycerides in the intestine. Plays a role in locomotion.
Subcellular location: Secreted {ECO:0000269|PubMed:18852466}.
Interaction partners:
- C2 domain-containing protein aex-1
- t-SNARE protein aex-4
- G-protein coupled receptor aex-2
- EF-hand domain-containing protein
Sequence:
MKLIFLLLLFGVSPIVCQDFEDGVFLAKITSIDEHDARKIGRRFGFEAQWKLQSYTDVYVGRRLRRRKRGIEDEIVAEMMLSQQVQFIEKLQGFRRYKRAPMTNKGYPVHVWNLTPSLYIREAWEDGFNASRVTVAVVDDGVDIKHVDLKSAFSPRVSFDFVRFGDLPTPKNSKEFEHGTQCAGLVAMEGQQCGLGVGHGATLGAIKLLGQDFLNDALEGDALAFQKDLIDIYSVSWGPKDDGKSAEKPAKFTEEAIKNGALHGRNGKGNIFVWASGNGGVNGDNCAYDGYVSNEYTLSFGVIDASGAPAAYGEGCSSVLAAVSGGDAMIQTTGLESTCSSISGSSASAAIASGIISLVLDANPTLSQRDIQHLIARTSNASAIRDVELYENSAGLNFHPKVGFGLLNAQKLVVMAATWENVAPQVTCEKMNLANGIIDNSDCDVTKVERVIVSGSIIHPHRGQVQIRLESPRGTISELLPLRPKDTSRDLLDWNFVSVNFFGENSRGIWKLHVTSEEDDVDFRVEMKMFKVVGTMS
Protein: Proteasome regulatory non-ATP-ase subunit 5 (Q38C86)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome subunit beta
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory ATPase subunit 6
- Proteasome regulatory non-ATP-ase subunit
- Proteasome subunit beta
- 26S proteasome regulatory subunit 4 homolog
- Proteasome subunit alpha type
- Probable 26S proteasome regulatory subunit rpn-6.2
Sequence:
MTDVDQWKCASFKQEEDHSEATDALLERINATAIPVLLRSTNSSLDDLVNELLALEKMARLGGDALSAKRLVVEILRIYRVHGDHEKMLDTLETLMRKRGQTKQSQGAMIAECGVLLTEGNLSREQRRIVLERVVHLTDSRIHVELEHVRFAIDLAKLMEDDGEKRAACDLLSGLHVETVTNMPRVEKLDALNRLIRLCLELEDYELARLVSRRINHRALSRPGALQAKLKYFELMREYFAQRRSYFHVARCWYETFLSETDETACVSALSSMAVHYLIAEHSSPKELEDHAECAAFSPATKFADRTAAIQGITTTLRKRLEENPQLQYLLEKFTSIELIRERVADDVEALCINHPQLAGFPERQALLRSRCSEHDLLVISRFYRRLRLVRLAELVGLTPQHTEEFLMMMVASRTLYAKIDRVDGLVVFEANKNANDVVTAWDEAVGRSVALLDKVSHLIVKERMLHNITLAQLQQSGATAS
Protein: SD10843p (Q95R38)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTGRPVHSVALGAATSVRSRRPGAAGSCPAAGTAPRSCCAGQGRYLVQRLSLLPGIRSCCFFGSPSQCTQADITCKRLADLGLGLFRGAGCLPTLIQGHFATCSVTWDAGASCYPSVIKF
Protein: LP11415p (Sclp, isoform A) (Q9VYS0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPFGNDITNIPNGGNNGGNNGGNNGNNDPNDGNDNRNTNISSEDPSEESGLSDDPSIPPHIARIGGIVTCPPIAGQGVIRVVQRCEDAKENHKLDLSSCELMQIPDAVYHLMRNTELITCNLSGNVLKSVSPKFSQKFSTITDLNLSHNKLSRLPEEFASLSALTKLNISNNSFIVLPQVVFKLQSLASLDAQNNAILEIDTDEAITSDNLALVDLRNNPLSRNCRRKLQSFKTPFHLEISKDVEDDW
Protein: Putative defensin-like protein 202 (Q2V3J6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Putative defensin-like protein 203
- Defensin-like protein 206
- Probable inactive purple acid phosphatase 27
Sequence:
MAKTQNFVCFTAVLLILILVSTEIPMIEGKTCKLFRGECPVDPCEPEKCDECCKATFGKQICGKCEQESTELHCHCRR
Protein: Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3) (P40426)
Organism: Homo sapiens (Human)
Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein Hox-A9
- Homeobox protein Meis2
- LIM homeobox transcription factor 1-beta
- Putative nucleotidyltransferase MAB21L1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
- Protein FAM222A
- Homeobox protein Hox-C9
- Homeobox protein PKNOX2
- Homeobox protein Hox-B8
- Homeobox protein Hox-A5
Sequence:
MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN
Protein: BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3) (Baiap3) (Q80TT2)
Organism: Mus musculus (Mouse)
Function: Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (By similarity). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (Probable).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12498718}. Recycling endosome membrane {ECO:0000250|UniProtKB:O94812}; Peripheral membrane protein {ECO:0000250|UniProtKB:O94812}. Late endosome membrane {ECO:0000250|UniProtKB:O94812}; Peripheral membrane protein {ECO:0000250|UniProtKB:O94812}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O94812}; Peripheral membrane protein {ECO:0000250|UniProtKB:O94812}. Cell membrane {ECO:0000250|UniProtKB:O94812}; Peripheral membrane protein {ECO:0000250|UniProtKB:O94812}. Note=Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration. {ECO:0000250|UniProtKB:O94812}.
Interaction partners:
Sequence:
MSTLLDIKSSVLRQVQVCPSFRRKTEQEPEVTNSQEPPTGAWKPGDGVEFFAHMRLILKKGDGRQGLPCPEVLLRSGSPAPAEPVDPNRGLRTLTQEEVEMLYEEALYTVLHRAGTMGPDQVDDEEVLLSYLQQVFGTSSEEHMEAIMRVKKAKAPTYALKVSVMRAKNLLAKDPNGFSDPYCMLGILPASSAPQEPSGQKEQRFGFRKGSKRSSPLPAKCIQVTEVKNSTLNPVWKEHFLFEIDDVNTDQLHLDIWDHDDDVSLAEACRKLNEVIGLKGMTRYFKQIVKSARANGTAGPTEDHTDDFLGCLNIPIREVPVAGADRWFKLEPRSSASRVQGDCHLVLKLITTQRDTVMSQRGRSGFLSYLLLLSRVLRFEHRVEEPNSSSWRGELSGPGTTVLCLHGAQSNLSPLQLAVLHWQVSSRHHQTRTLDYGYLLGLLEDVQAHWEEAASLPQEQEESLADSFSAFSEFGLRLLRQLRDYFPATNSTAVYRLELLLKCLEKLQLFQPAFEICPFETELSMDIAAALKRGNREWYDQLLNTKSPREQPGPQRLAGLVELADIIYEDLQLCYGVYASLFHGILKVDFFTLTFRQLERLVAEEAWVLTEELSPKMNLEVASGLFELYLTLADTQRFWSCIPGRESRSLALAGIHTPFLPAVKLWLQVLRDQAKWRLQGAVDVDTLEPVDAASKHSSSAATASLCLSHIQELWVRLAWPDPSQAQGLGTQLSQDMCEASLFYTELLRKKVDTQPGAAGEAVSEQLCVVLNNVELVRRASGQALRGLAWSEGASGLEGVLPRPLLSCIQALDEDLHREAHTVTAHLTSKMVADIRKYIQHISLSPDSIQNDEAVAPLLKYLDEKLALLNDALVKENLNRVLEALWELLLQAILQALSANRDVSADFYGRFHFTLEALVSFFHAEGQGLPLENLRDGSYKRLQEELRLHKCSTRECIEQFYLDKLKQRSLEQNRFGRLTVRCHYEAAEQRLAVEVLHAADLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKARTLHPVYDELFHFSVPAEACRRRGACVLFTVMDHDWLSTNDFAGEAALGLGGISGIARPHVGGGMRPGQPITLHLRRPRAQVRSALRMLEGRTSREAQEFVKKLKELEKCMEADL
Protein: Beta-TrCP (Beta-transducin repeat-containing protein) (Q91854)
Organism: Xenopus laevis (African clawed frog)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. May participate in Wnt signaling.
Interaction partners:
Sequence:
MEGFSCSLQPPTASEREDCNRDEPPRKIITEKNTLRQTKLANGTSSMIVPKQRKLSANYEKEKELCVKYFEQWSECDQVEFVEHLISRMCHYQHGHINTYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCSAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGKTPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRVLMGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPGLA
Protein: Prothymosin alpha (Q53S24)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD
Protein: Platelet glycoprotein 4 (Glycoprotein IIIb) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (E9PLT1)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
Interaction partners:
Sequence:
MMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVGTEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLWGYRDPFLSLVPYPVTTTVGLFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTIK
Protein: Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) (Q8H5X5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probably involved in membrane trafficking.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MAGRYDSNPFEEDDVNPFSEQARGKAGGQPSYGGGAFYMPNPRNVPSVSSNSRLSPLPPEPAAFGATVDIPLDSSKDLKNREKELQAREAELNKREKELKRREEAAARAGIVIEEKNWPPFLPLIHHDITNEIPSHLQRMQYVAFASFLGLACCLFWNVIAVTSAWVKGEGVKIWLLAIIYFISGVPGAYVLWYRPLYNAMRTDSALKFGLFFLVYLFHILFCVFSAVAPPVVFEGKSLAGILPAIDLISKNALVGIFYFVGFGLFCVESLLSIWVIQQVYMYFRGSGKAAEMKRDATRGAMRAAF
Protein: Paired box protein Pax-6 (Oculorhombin) (P63016)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P63015}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00381, ECO:0000269|PubMed:24952136}.; SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus {ECO:0000269|PubMed:24952136}.
Interaction partners:
- T-box brain transcription factor 1
- Neurogenic differentiation factor 1
- Barrier-to-autointegration factor
- SRY-box transcription factor 2
- Oligodendrocyte transcription factor 2
- Transcription factor Maf
- Nestin
- Homeobox protein NANOG
- Forkhead box protein G1
- SRY-box transcription factor 17
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGQGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit) (O75306)
Organism: Homo sapiens (Human)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891, ECO:0000305|PubMed:9585441}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q641Y2}; Matrix side {ECO:0000250|UniProtKB:Q641Y2}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- Acyl carrier protein, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
Sequence:
MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
Protein: Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog) (uS12 prolyl 3-hydroxylase) (Q8N543)
Organism: Homo sapiens (Human)
Function: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Subcellular location: [Isoform 1]: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein uS12
- Elongation factor Tu, mitochondrial
- Polyadenylate-binding protein 1
- Caprin-1
Sequence:
MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE
Protein: Guanine nucleotide-binding beta subunit-like protein (Q385S8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone deacetylase
- Histone deacetylase 2
- Histone H4
- Histone H4
- Histone H3 variant
- Histone H3, putative
- Histone H2A
- Chromatin assembly factor 1 subunit B, putative
- DNA damage-binding protein 1
Sequence:
MRIKVDVELHKREINNITHVQEVFKSLSDTVETRLVTDKEALTRLVSNALAKGTLRTIVPELTERLCHPALYEDCLSVLCGVMFDSERVERGESLDGFVSFITQLPDNEQKKAKGDIVQRAMTYLSKPRRLDCSRNLLLPYAEVIAVLTKVDMLNIRNVVVALMQMIRLDTTRTAGITCLGKLVEVAHGLLLERLDQHTLQTLRDTVIFARQDDILSYDVEYIMEAFGWDQSPKFVNFSVRHSGVHHKSAILTLAYSGGNGSREVVVTSSVDGTIGTWDHSGALTENLVLSRHYASSIDFADHGRALIVGTVGRTASIPPAIVIYTAQPTYNEESNWQEKCGAEPRDAMFITTVKCLRSFSSMRYCCGATVATGSTLILYDGTQVIQEYNGHSDVISAMHVIPDRDNTVVTGSRDCSVMVYDLRMPQSVTTTSAHRHYSTVTSIGSCGDFLFTSGLDRRVVVNDLRMMGQGMATQDLDSAVLSISVNSSMVCAASTLTGVHLINFGNNPILTCRADSMKMSPRYNAVSWNAQGDVLYAGGDNNTLDMFTRRFPETEAYAA
Protein: Major urinary protein 20 (Darcin) (Major urinary protein 24) (Q5FW60)
Organism: Mus musculus (Mouse)
Function: Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male. Promotes spatial learning by rapidly conditioning preference for its remembered location among females and competitor males so that animals prefer to spend time in the site even when scent is absent. In addition to promoting a rapid attraction response, also elicits ultrasonic vocalizations and urinary scent marking in females which do not occur immediately after exposure. Stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in females. Promotes male aggressive behavior. Response to Mup20 is mediated by a neural circuit extending from the accessory olfactory bulb to a subset of nitric oxidase synthase-expressing neurons in the medial amygdala. As well as acting as a pheromone itself, binds most of the male pheromone, 2-sec-butyl-4,5-dihydrothiazole, in urine and is responsible for its slow release from scent marks.
Subcellular location: Secreted {ECO:0000269|PubMed:15934926, ECO:0000269|PubMed:20525243, ECO:0000269|PubMed:25279835, ECO:0000269|PubMed:28522864}.
Interaction partners:
- Major urinary protein 3
- Major urinary protein 12
- Major urinary protein 21
- Major urinary protein 1
- Carboxylesterase 3A
- Serine protease inhibitor A3K
Sequence:
MKLLVLLLCLGLTLVCVHAEEASSMERNFNVEKINGEWYTIMLATDKREKIEEHGSMRVFVEYIHVLENSLALKFHIIINEECSEIFLVADKTEKAGEYSVTYDGSNTFTILKTDYDNYIMIHLINKKDGETFQLMELYGREPDLSSDIKEKFAQLSEEHGIVRENIIDLTNANRCLEARE
Protein: Angiogenin-3 (EC 3.1.27.-) (Angiogenin-related protein 2) (EF-5) (P97802)
Organism: Mus musculus (Mouse)
Function: May promote vascularization of normal and malignant tissues (By similarity). Has low ribonuclease activity (in vitro).
Subcellular location: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity). {ECO:0000250|UniProtKB:P03950}.
Interaction partners:
- Angiogenin ribonuclease 6
Sequence:
MVMSPGSLLLVFLLSLDVIPPTLAQDNYRYIKFLTQHYDAKPTGRDYRYCESMMKKRKLTSPCKEVNTFIHDTKNNIKAICGENGRPYGVNFRISNSRFQVTTCTHKGGSPRPPCQYNAFKDFRYIVIACEDGWPVHFDESFISP
Protein: Odorant receptor 85f (Q9VHE6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEPVQYSYEDFARLPTTVFWIMGYDMLGVPKTRSRRILYWIYRFLCLASHGVCVGVMVFRMVEAKTIDNVSLIMRYATLVTYIINSDTKFATVLQRSAIQSLNSKLAELYPKTTLDRIYHRVNDHYWTKSFVYLVIIYIGSSIMVVIGPIITSIIAYFTHNVFTYMHCYPYFLYDPEKDPVWIYISIYALEWLHSTQMVISNIGADIWLLYFQVQINLHFRGIIRSLADHKPSVKHDQEDRKFIAKIVDKQVHLVSLQNDLNGIFGKSLLLSLLTTAAVICTVAVYTLIQGPTLEGFTYVIFIGTSVMQVYLVCYYGQQVLDLSGEVAHAVYNHDFHDASIAYKRYLLIIIIRAQQPVELNAMGYLSISLDTFKQLMSVSYRVITMLMQMIQ