wanglab/gogpt-training-data huggingface dataset:
Protein: Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-) (Q9NYA1)
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion. In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway. Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity. In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14575709, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:29662056}. Nucleus {ECO:0000269|PubMed:14575709, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:29662056}. Cell membrane {ECO:0000269|PubMed:19854831}. Endosome membrane {ECO:0000269|PubMed:24929359}; Peripheral membrane protein {ECO:0000269|PubMed:24929359}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:24929359}. Synapse {ECO:0000250|UniProtKB:Q8CI15}. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity). {ECO:0000250|UniProtKB:Q8CI15, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:24929359}.
Interaction partners:
- Sphingosine-1-phosphate lyase 1
- Acid ceramidase
- Sphingosine-1-phosphate phosphatase 1
- Neutral ceramidase
- TNF receptor-associated factor 2
- Sphingosine-1-phosphate phosphatase 2
- Alkaline ceramidase 1
- Alkaline ceramidase 2
- Ceramide synthase 6
- Sphingosine 1-phosphate receptor 3
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
Protein: Transcription factor IIIA (TFIIIA) (Q9UTL5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Is required for correct transcription of 5S RNA genes by RNA polymerase III. Also binds the transcribed 5S RNA's. Initiates transcription of the 5S ribosomal RNA gene.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor IIIB 60 kDa subunit
- TATA-box-binding protein
- Transcription factor tau subunit sfc4
- Pre-mRNA-splicing factor sap61
- Pre-mRNA-splicing factor sap62
- KIN17-like protein
Sequence:
MCHFNELSIEIESKNLRSAKKIFHCPYEECGKKYSRPSLLEQHLRTHSNERPFVCDYTGCSKAFYRKSHLKIHKRCHTNVKPFSCHYDGCDAQFYTQQHLERHIEVHRKPKPYACTWEGCDECFSKHQQLRSHISACHTHLLPYPCTYQDCELRFATKQKLQNHVNRAHEKIISYSCPHESCVGHEGFEKWSQLQNHIREAHVPSCSICGRQFKTAAHLRHHVVLHQTTLEERKTYHCPMEGCKKSFTRSSALKKHISVIHEGNMAFHCDSCGTKFGYKHMLQRHLERGTCKKAHKPYINECGIKHDGIEGVAIHDQKEKELSSNLVSDVAKKIINEVTGHGYKEAREYSCSFPECNYRFKRLYDMHRHLNSHH
Protein: Stress-induced-phosphoprotein 1 (STI1) (Q7ZWU1)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q60864}. Nucleus {ECO:0000250|UniProtKB:Q60864}. Dynein axonemal particle {ECO:0000269|PubMed:33263282}.
Interaction partners:
- HATPase_c domain-containing protein.
- Heat shock cognate protein HSP 90-beta
- Heat shock protein HSP 90-alpha isoform X2
- CS domain-containing protein.
- Activator of 90 kDa heat shock protein ATPase homolog 1
- Activator of 90 kDa heat shock protein ATPase homolog 1
- Heat shock 70 kDa protein 4
- Uncharacterized protein.
- Heat shock protein 75 kDa, mitochondrial
- Hamartin isoform X5
Sequence:
MEAANALKEKGNKALSAGNLDEAVKCYTEAIKLDPKNHVLYSNRSAAYAKKKEFTKALEDGSKTVELKADWGKGYSRKAAALEFLNRFEEAKKTYEEGLRHEPTNAQLKEGLQNMEARLAEKKFMNPFNSPNLFQKLESDPRTRALLSDPSYKELIEQLRNKPSDLGTKLQDPRVMTTLSVLLGVELGNVDEEEEDTPPPPPPQPKKETKPEPMEEDLPENKKQAQKEKELGNEAYKKKDFETALKHYGQARELDPANMTYITNQAAVYFEMGDYSKCRELCEKAIEVGRENREDYRLIAKAYARIGNSYFKEEKNKEAIQFFNKSLAEHRTPEVLKKCQQAEKILKEQERVAYINPDLALEAKNKGNESFQKGDYPQAMKHYSEAIKRNPNDAKLYSNRAACYTKLLEFLLAVKDCEECIRLEPSFIKGYTRKAAALEAMKDFTKAMDAYQKAMELDSTSKEATDGYQRCMMSQYNRNDNPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSDHLKNPVIAQKIQKLMDVGLIAIR
Protein: Sideroflexin-1 (Q99JR1)
Organism: Mus musculus (Mouse)
Function: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:11274051}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSGEVPPNINIKEPRWDQSTFIGRASHFFTVTDPRNILLTNEQLENARKVVHDYRQGIVPAGLTENELWRAKYAYDSAFHPDTGEKMTLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKRVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGTRLGESTNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVTLVGFCLVFATPLCCALFPQKSSMSVTSLEDELQASIQRTHPEIRRVYFNKGL
Protein: Large ribosomal subunit protein mL40 (Q9VGP7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL32m
- Ribosomal protein
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL30m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL29m
Sequence:
MSLLGAFARLSLQRSGGVAGAAFARCLHTTPVLCAEPLKKKKKLDPQIVKQREDRKKKKIEKQIRRLEKNARQLKPVDELEVPLELIDEKDKRQRKLAPLTIDQLEERALLKKQWAHYKHDERVADFQIIDRLVQAQNKALAELRRESEELYQAAIDIDPQLLPVAVKGPVATPPIKDYVSPDGDYLHQSMKWEVK
Protein: RRM domain-containing protein (Q5AB84)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Nucleolar protein 56
- rRNA 2'-O-methyltransferase fibrillarin
- RNA-binding GTPase
- Protein PXR1
- Pre-rRNA-processing protein ESF2
- ATP-dependent RNA helicase DBP2
- Nucleolar GTP-binding protein 1
- H/ACA ribonucleoprotein complex subunit
- DNA-directed RNA polymerase subunit
- RNA cytidine acetyltransferase
Sequence:
MAKASKVDKKLSKKKEEKPAKKVEEESSSEESSSDDSSSEESSSDDDSSDDSSSSSSDEGSDSDSSDEEEVEKKESSSDESDDEDKKEESSSGSDEEEKKEEKSSSSDSEDSSSSDSSSSESDSDSDSDSDSDSEEEPSKKRKAEESKEEESAPVKKSKPAASTEEPATLFVGRLSWNIDDAWLKREFEHIGGVIGARVIMERATGKSRGYGYVDFESKSAAEKALEEMQGKEIDGRPINLDMSTGKPHASKSNNDRAKQYGDSQSPPSDTLFIGNLSFNANRDNLFNVFGEYGNVISCRVPTHPDTQQPKGFGYVQFSSVDEAKAALEAMNGEYIEGRPCRLDFSTPRDNTNNNNNNNRRGGFGGGFGGRERSATPRSGNSTPRPNKSTEFKGTKKTFD
Protein: Odorant-binding protein 56g (A1ZBQ4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- GEO08953p1
- General odorant-binding protein 57c
- IP02289p
- Accessory gland-specific peptide 26Aa
- Serpin 28F
- IP02285p
- ACP53C14A
- Odorant-binding protein 19b
- GEO08224p1
Sequence:
MRATFALTLLLGCLSGILAQQANIDSSVSKELVTDCLKENGVTPQDLADLQSGKVKAEDAKDNVKCSSQCILVKSGFMDSTGKLLTDKIKSYYANSNFKDVIEKDLDRCSAVKGANACDTAFKILSCFQAAN
Protein: Maltose fermentation regulatory protein MAL13 (P53338)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulates the coordinate transcription of structural MAL1S (maltase) and AGT1 (maltose permease) genes.
Subcellular location: Nucleus.
Interaction partners:
- General alpha-glucoside permease
- Alpha-glucosidase MAL12
- Alpha-glucosidase MAL32
- Maltose permease MAL31
- Oligo-1,6-glucosidase IMA5
- Oligo-1,6-glucosidase IMA1
- Oligo-1,6-glucosidase IMA2
Sequence:
MTLTKQTCAKQACDCCRIRRVKCDGKRPCSSCLQNSLDCTYLQPSRKRGPKSIRLRSLKRIAEVQRESGPNTIATAPVIYKRVPKKLIDQCLRLYHDNLYVIWPLLSYDDLHKLLEEKYNDNYVYWFLTALSAATLSDLQTEIKSEEEVTFTGKQLSNLCISSCQQFDDLDNSNIFNIMTYYCLHRSFAQISNARTSYRLCCEAVGLITVAGLHREETYGSLTFEEQQLRRKLYYLLLMTERYYAIYLHCATSLDATIAPPQLELVTDPQLSMDSFLEMIRVFTVPGKCFFDALAADSTDASCTEESLKKIWNELHTTSSEIEPWSNGYIDISFSRHWIRILAWKLAYQMRGSNFSLNANNGQIPIEIARDMLIDTYLTPENLYDVHGPGVPVKTLEIATALVDIVGQYDHNMKLEAWNVLHDVCKFAFSLNHYNNDMLKRFSTKCQNALITLPISKPLQLDGYPKDNEDIDP
Protein: Epithelial sodium channel subunit gamma (ENaC subunit gamma) (ENaCG) (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Sodium channel epithelial 1 subunit gamma) (P51170)
Organism: Homo sapiens (Human)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:24124190}; Multi-pass membrane protein {ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833}.
Interaction partners:
- Epithelial sodium channel subunit alpha
- Epithelial sodium channel subunit beta
- E3 ubiquitin-protein ligase NEDD4-like
- E3 ubiquitin-protein ligase NEDD4
- Epithelial sodium channel subunit delta
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 4 subunit alpha
- Sodium channel regulatory subunit beta-1
- Cystic fibrosis transmembrane conductance regulator
- Serine/threonine-protein kinase Sgk1
Sequence:
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL
Protein: Putative aliphatic sulfonates transport permease protein SsuC (P75851)
Organism: Escherichia coli (strain K12)
Function: Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Aliphatic sulfonates import ATP-binding protein SsuB
- Alkanesulfonate monooxygenase
- Putative aliphatic sulfonates-binding protein
- FMN reductase
- Taurine-binding periplasmic protein
- Taurine import ATP-binding protein TauB
- Probable D,D-dipeptide transport system permease protein DdpC
- Taurine transport system permease protein TauC
- Alpha-ketoglutarate-dependent taurine dioxygenase
Sequence:
MATPVKKWLLRVAPWFLPVGIVAVWQLASSVGWLSTRILPSPEGVVTAFWTLSASGELWQHLAISSWRALIGFSIGGSLGLILGLISGLSRWGERLLDTSIQMLRNVPHLALIPLVILWFGIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPSIMVGVRFALGLMWLTLIVAETISANSGIGYLAMNAREFLQTDVVVVAIILYALLGKLADVSAQLLERLWLRWNPAYHLKEATV
Protein: General transcription factor II-I repeat domain-containing protein 2 (GTF2I repeat domain-containing protein 2) (Transcription factor GTF2IRD2) (Q99NI3)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MAQVAVTTQPTDEPSDGRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVYVVGTERGCAFVNARQDLQKDFAQHCQGEGLPEEKPLCLGNGEACPGEAQLLRRAVQDHFCLCYRKALGTTAMVPVPYEQMLQDEAAVVVRGLPEGLAFQHPDNYSLATLKWILENKAGISFAVKRPFLGAESQLGGLGMVTDAGRPTVPPNDSYGPVSVKTEPMEDSGTSPRAAAMLIKTESEDPNYNVCNVQGSQHFSASSDVTGMELPSEESTRMVALETNEDPETEVKMEGNASPSNLVNSAAGVEDLRIIQVTVADNEKERLSGLEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILDAADFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSVSVSKEYNLRRHYQTNHSRHYDQYSGQAREEKLRELKRGLRKYLLGASEIVCPEQPFPNASPPTNSAVQPAEEVAGSLWEKLRQKIRSFVAYSIAIDEITDINDTTQLAIFIRGVDDNFDVSEELLDTVPMTGAKSGNEIFLRVEKSLKKFSIDWSKLVSVASTGTPAMMDANSGLVTKLRARAASCCKGADLKSVRCIIHPEWLCAQKLRMGHVMDVVVDSVNWICSRGLNHGDFTTLLYELDSQYGSLLYHTALKWLGRGLVLRRFFESLEEIDSFMSSRGKPVPQLSSRDWILDLAFLVDMTTHLNTLDASLQGHSQIVTQMYDFIRAFLAKLCLWETHLARNNLAHFPTLKSVSRSESDGLNYIPKIVELKAEFQRRLSDFKSCESELTLFSSPFSTTIDSVREELQMEVIDLQCNTVLRTKYDKVGVPDFYKHLWSSYPKYRSHCARMLSMFSSTHICEQLFSILKLSKKEAQWGAALQVAT
Protein: Flotillin (W5ULK7)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU366054}. Endosome {ECO:0000256|RuleBase:RU366054}.
Interaction partners:
- Sorbin and SH3 domain-containing protein 1 isoform X4
- Flotillin
- Flotillin
Sequence:
MFYTCGPNEAMVVSGCCRAPPLMVAGGRVFVIPCIQQIQRISLNTLTLNVKSDKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKSETEISHIALETLEGHQRAIIAHLTVEEIYQDRKKFSEQVFKVASSDLVNMGIGVVSYTLKDVHDDQDYLNSLGKARTAQVQKDARIGEAQYKRDAVIREAHAMQEKVSAQYKNEIEMAKAQRDYELKKAVYDMEVNAKKAESEMAYQLQVAKTKQRIEEEKMQVQVVERAQQITLQEQEITRKEKELEARVMKPAEAEKYKLEKLAEAERLQLIMEAEAEAESIRIKGEAEAFATLAKGRADAEQMAKKAEAFNQYKEGAMVDMLLEKLPLMAEEITKPLSAAQKITMVSSGGSEVGAAKLTGEVLDIMVRLPQAVEKLTGVSISQVTSTRMG
Protein: Serine peptidase inhibitor Kazal type 5 (E7EWP9)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKIATVSVLLPLALCLIQDAASKNEDQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSI
Protein: Uncharacterized protein (Q38BX6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vacuolar assembly protein vps41, putative
- Ras-related protein Rab-7b
- Rab GDP dissociation inhibitor
- Small GTP-binding protein Rab28, putative
- Small GTP-binding protein Rab7, putative
- ATP synthase regulation protein NCA2
Sequence:
MMNLGETLDTGSADGRPGPSPTLSVGSGVTPAPLNSSTVHLTRTVDSELGDTNIGYDIAVSPLNAETESLATRRPSALDIFPPAGLNRTDDGKPSSSHPASKPYVTGGDEGKKQSECWDADENFLLKHTKHVFILTSAGKPIFSRYGNENTISELFGVFQVLITMAQQKQDGGTLHWINAADLTIYFHVDGGLYYVLVTRGGESPYSCRRQLKQLHYQLLSLVPNVNDILSRCPSYDLRRLVSSTDGGVLRQLIKRNSREECYMFRCLAASPLSVASRCHLTSILTQHYRSGFSKGDISSEGGVAADCHLFSFFFFRGRVVCMVGLADGKVSLHIDDTLILLNFVRCLPLSQVGEIWAPLCLPRYNDTGYLWCYCTDMGAMVNELDSSESGYVAKDDHHGVEKPTAKEPFAETKRSELLLVQVASSQLAFAPLSMQAHCIAQMLQTSFTPLIDELEARENIPLSLALPNVVAQRQQEVHEKISRLLTRAEQQYPECLPSASHAPSSLQLPPVPVHPYGLQWFALILKQPSNVIYSEPSPAMKLDPRLKKRQLRLLVRLRYELALRTNQNEQLLVLNTEEVNVVVMKPTPNLLTSLVQQFGSRDECVNNVSLSSGNATALCSHLQELLLLFSPHVPKHQMLLCAVSVAVGVMARECELSLQQPRSSKSRVW
Protein: Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) (Q08351)
Organism: Mus musculus (Mouse)
Function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P40238}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P40238}. Golgi apparatus {ECO:0000250|UniProtKB:P40238}. Cell surface {ECO:0000250|UniProtKB:P40238}.
Interaction partners:
- Thrombopoietin
- Tyrosine-protein kinase JAK2
- Erythropoietin
- Interleukin-3
- Integrin alpha-IIb
- Granulocyte colony-stimulating factor
- Calreticulin
- Non-receptor tyrosine-protein kinase TYK2
- Platelet glycoprotein IX
- Interleukin-11
Sequence:
MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP
Protein: Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) (Q9H2X9)
Organism: Homo sapiens (Human)
Function: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q91V14}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91V14}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q91V14}. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses. {ECO:0000250|UniProtKB:Q91V14}.
Interaction partners:
- Serine/threonine-protein kinase WNK3
- Gamma-aminobutyric acid receptor subunit alpha-1
- Serine/threonine-protein kinase WNK1
- Neuropilin and tolloid-like protein 2
- Neurotrophic factor BDNF precursor form
- Serine/threonine-protein kinase WNK4
- STE20/SPS1-related proline-alanine-rich protein kinase
- BDNF/NT-3 growth factors receptor
- Vesicular inhibitory amino acid transporter
- Glutamate decarboxylase 2
Sequence:
MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
Protein: Bacterioferritin BfrB (EC 1.16.3.1) (Bacterioferritin beta subunit) (BFR beta subunit) (Nonheme-iron-containing cytochrome b557) (Q9HY79)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:35327558, ECO:0000269|PubMed:7998985}. Note=Forms 24 subunit ferritin complexes (PubMed:35327558). {ECO:0000269|PubMed:35327558}.
Interaction partners:
- Bacterioferritin-associated ferredoxin
- Heme oxygenase PigA
- Bacterial ferritin
- Ferrochelatase
- ferroxidase
- Ferredoxin--NADP reductase
Sequence:
MKGDKKVIQHLNKILGNELIAINQYFLHSRMWNDWGLKRLGAHEYHESIDEMKHADKLIERILFLEGLPNLQDLGKLLIGENTQEMLQCDLNLELKATKDLREAIVHCEQVHDYVSRDLLKDILESEEEHIDYLETQLGLIQKVGLENYLQSHMHEDD
Protein: Anoctamin (A0A0G2K1M7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
- Phospholipid scramblase
- Phospholipid scramblase
- XK-related protein
- Phospholipid scramblase
Sequence:
MGDVPDSRRPFLAPHTPLPSGLVLENFDQTIVCSTFGSLESQEDFRTPEFEEFNGKPDSLFFTDGQRRIDFVLVYEDESKKENNKKGTNEKQKRKRQAYESNLISHGLQLEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSTFDTFNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSSGIYKAAFPLHDCKFNYKSEDPNCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQPRPEYEAQCNHVVINEITQEEERIPFTTCGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPMGRLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGLIAERIGGVADSSVRPKLE
Protein: Cytochrome P450 71A25 (EC 1.14.-.-) (Q9STK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- NAD
- UDP-glycosyltransferase 76E11
- UDP-glycosyltransferase 91B1
- M phase phosphoprotein 10
- NAD
- NAD
- Probable ubiquitin-conjugating enzyme E2 26
- Aldo-keto reductase family 4 member C11
- UDP-glycosyltransferase 85A4
- Aldo-keto reductase family 4 member C10
Sequence:
MMMMIILLWSIIFMTILFLKKQLSGKKGKTPPSPPGLPLIGNLHQLGRHTHRSLCDLSRRYGPLMLLHLGRVPVLIVSSADMAQEILKTHDQAFANRPRSKLSQKLLYNNRDVASAPYGEYWRQMKSVCVIHLLSNKMVRSFRDVREEEITLMMAKIRKSSSLPFNVSKVLECLTNDVICRVALGRKYGGETDFKKLTDRLSELLGTFSIGSFVPWLAWVDWIRGWDAQLDKMGKDLDDFFEKVVQDHEDGDRRDGTDLIDALLRVKREKSPGFEIERVSIKAITLDVFVGGSDTSFTLLEWAMTELLRHPKSLNRLQEEVRTICKGKSRVSEDDIQGMKYLKAVIKEALRLHPPFPMMAPHESTEDVKLRDYHIPAGTQVMMNAWAIGREVATWGPDAEEFKPERHLDTSVDFRGQNFELLPFGAGRRICPAVSFAVVLNEVVLANLVHGFDWKLPEESKEDKTDVAESSGFSVHREFPLYAVASPYLT