wanglab/gogpt-training-data huggingface dataset:
Protein: Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5) (Q8K0L2)
Organism: Mus musculus (Mouse)
Function: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleoside triphosphate diphosphohydrolase 5
- Ectonucleoside triphosphate diphosphohydrolase 6
- Uridine-cytidine kinase-like 1
- Adenylate kinase 4, mitochondrial
- Adenosine kinase
- Uridine-cytidine kinase 1
- Uridine-cytidine kinase 2
- Nucleoside diphosphate kinase 6
Sequence:
MGLSWKERVFMALLGVAAASGLTMLVLILVKAINVLLPADTKFGIVFDAGSSHTSLFVYQWPANKEKDTGVVSQALTCQIEGPGISSYTSDPTQAGESLKSCLEEALALIPQAQHPETPTFLGSTAGMRLLSQKNSSQARDILAAVSQTLSKSPVDFWGAKILAGQDEGAFGWITINYVLGMLLKYSSGQWILPEEGMLVGALDLGGASTQISFVPQGPILDQSTQVTFRLYGANYSVYTHSYLCFGRDQILNRLLAKLAQDRLSSQVAPVRHPCYHSGYQAILPLSSLYDSPCIHTTDSLNHTQNLTVEGTGDPGNCVVALRSLFNFSSCKGQKDCAFNGIYQPPVHGQFYAFSNFYYTFHFLNLTSRQSLNTVNDTVWKFCQKPWKLVEVSYPGQERWLRDYCASGLYILVLLLEGYKFSEETWPNIQFQKQAGDTDIGWTLGFMLNLTGMIPAEAPTHWRAQSYSIWTAGVVFAVLTLVAILGAAAIQIFWTQD
Protein: Pentatricopeptide repeat-containing protein At1g74600, chloroplastic (Q9CA56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Ribonuclease P protein subunit P38-like protein
- Lysine-specific demethylase JMJ29
- Pentatricopeptide repeat-containing protein At4g21170
- Disease resistance protein
- Probable disease resistance protein At1g52660
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Acyltransferase GLAUCE
- Phosphoglycerate mutase family protein
- Leucine-rich repeat
- Phox
Sequence:
MNCLANESLNSLKISPFSTSRLLSSVTNFRNQLSFSSKDSSSSSAPFNPFRFFNDQSNSRLCNLRTTKILQAHLLRRYLLPFDVFLTKSLLSWYSNSGSMADAAKLFDTIPQPDVVSCNIMISGYKQHRLFEESLRFFSKMHFLGFEANEISYGSVISACSALQAPLFSELVCCHTIKMGYFFYEVVESALIDVFSKNLRFEDAYKVFRDSLSANVYCWNTIIAGALRNQNYGAVFDLFHEMCVGFQKPDSYTYSSVLAACASLEKLRFGKVVQARVIKCGAEDVFVCTAIVDLYAKCGHMAEAMEVFSRIPNPSVVSWTVMLSGYTKSNDAFSALEIFKEMRHSGVEINNCTVTSVISACGRPSMVCEASQVHAWVFKSGFYLDSSVAAALISMYSKSGDIDLSEQVFEDLDDIQRQNIVNVMITSFSQSKKPGKAIRLFTRMLQEGLRTDEFSVCSLLSVLDCLNLGKQVHGYTLKSGLVLDLTVGSSLFTLYSKCGSLEESYKLFQGIPFKDNACWASMISGFNEYGYLREAIGLFSEMLDDGTSPDESTLAAVLTVCSSHPSLPRGKEIHGYTLRAGIDKGMDLGSALVNMYSKCGSLKLARQVYDRLPELDPVSCSSLISGYSQHGLIQDGFLLFRDMVMSGFTMDSFAISSILKAAALSDESSLGAQVHAYITKIGLCTEPSVGSSLLTMYSKFGSIDDCCKAFSQINGPDLIAWTALIASYAQHGKANEALQVYNLMKEKGFKPDKVTFVGVLSACSHGGLVEESYFHLNSMVKDYGIEPENRHYVCMVDALGRSGRLREAESFINNMHIKPDALVWGTLLAACKIHGEVELGKVAAKKAIELEPSDAGAYISLSNILAEVGEWDEVEETRKLMKGTGVQKEPGWSSV
Protein: Fibulin-1 (A0A0G2JY81)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR036313}.
Interaction partners:
Sequence:
MERPAPSRLVPLPLLLLGSLSLLAARANADISMEACCTEGNQMANQHRDCSLSYTSESKECRMVQEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLETIFIKRCCHCCMLGRAAQARGQTCEPNLMISYQCGLVFRACCVKGQENSDFVRGDGTDLQDPAKIPEEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGYYFDGISRTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDTVRCIKSCRPTDEACMRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVTPLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVEMLQKLTFDGCLRPREEYSTWSNSPPSATFQRILHT
Protein: Asc-type amino acid transporter 1 (Asc-1) (D-serine transporter) (Solute carrier family 7 member 10) (P63116)
Organism: Rattus norvegicus (Rat)
Function: Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P63115}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with OLIG2 in astrocytic processes. Localizes to the plasma membrane in mature adipocytes and to intracellular structures in preadipocytes. {ECO:0000250|UniProtKB:P63115}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A2
- Neutral amino acid transporter B
Sequence:
MRRDSDMASHIQQPGGHGNPGPAPSPSPGPGPGPGASERVALKKEIGLVSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPATASRVLSMACLMLLTWVNSSSVRWATRIQVIFTGGKLLALSLIITVGFVQIFQGHFEELRPTNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEELVDPRKNLPRAIFISIPLVTFVYTFTNVAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTSSRLCFSGAREGHLPSFLAMIHVRRCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLVLRWRRPALHRPIKVNLLVPVVYLVFWAFLLVFSFISEPMVCGVGIIIILTGVPIFFLGVFWRSKPKCVHRFTESMTRWGQELCFVVYPQGSLEEEENGPMGQPSPLPITDKPLKTQ
Protein: DUF4333 domain-containing protein (O53280)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MAHSIVRTLLASGAATALIAIPTACSFSIGTSHSHSVSKAEVARQITAKMTDAAGNKPESVTCPSDLPAEVGAELNCEMKIKDRTFNVNVTVTSVDGSDVKFDMVETVDKNQVANIISDKLFQRVGARPDSVTCPDNLKGVEGAKLRCRLTDGSKTYGISVIVTSVDAGDVNFDFKVDDHPE
Protein: Probable electron transfer flavoprotein subunit beta (Beta-ETF) (Changed intracellular redox state protein 1) (P42940)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Probable electron transfer flavoprotein subunit alpha, mitochondrial
- Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
- DASH complex subunit SPC34
- Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
- NADPH-dependent diflavin oxidoreductase 1
- Succinate--CoA ligase subunit alpha, mitochondrial
- Protein CFT1
- ADP-ribosylation factor GTPase-activating protein GCS1
- Siderophore iron transporter 1
- Small ribosomal subunit protein mS47
Sequence:
MSAKQQLRILVPVKRVVDFQIKPRVNKTLTGIETSGIKFSINPFDDIAVEEAIRIKEKNKSLVESTHAVSIGSAKAQDILRNCLAKGIDTCSLIDSVGKENIEPLAIAKILKAVVEKKGSNLVLMGKQAIDDDCNNTGQMLAGLLNWPQATNAAKVEFLDNGRVQVTREIDDGEEVIEASLPMVITTDLRLNTPRYVGLPKLMKAKKKPIEKLDIAKDFPEINIEPQLKIVSMEEPKTKSPGVKLNSVDELIEKLKEVKAI
Protein: Core gene UL33 family protein (ORF 67.5) (ORF67A) (O40944)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MEYASDQLLPRDMQILFPTIYCRLNAINYCQYLKTFLVQRAQPAACDHTLVLESKVDTVRQVLRKIVSTDAVFSEARARP
Protein: Uncharacterized protein (Q385U2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Cysteine-rich, acidic integral membrane protein
Sequence:
MNRILFALAIIFYLPIPLSVIKGSCKEIPTHQQPQAPYIPNIQKQTKEVLTPSQQEDKQNFSPTLHKIESARQFHYDDSTNIDGNKSIQHQTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEGEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEGEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEEEDEDEDDTAVTDVNDNNSANTSNEDEGKEELEFTIAPSPVFLPPPPVSDENSTLLDGNDLSVDRGNYCSLLFSFVFVFLTFVV
Protein: Cadherin-4 (A1L1M6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
Interaction partners:
- Catenin beta-1
- Catenin alpha-2
- Catenin
- Junction plakoglobin a.
- Catenin, beta 2.
- Junction plakoglobin b.
- Catenin alpha-1
Sequence:
MAKMKTGCAILVACALVVGTSLGSHWNAQTVAPCRPGFSQSFYTVFVPRVVLQGLNIHKDTLLSSGHVKFETCHRIEELSFESSDPKFSVRPDGSLYAEQDVTNLTEPIQFMVTARDRAGEYIWETTVKLALAGHPLSPPFNQIAGEAIYGGPSHYHYQNPRLITFPRQRQRGLSNGLRRQKRDWVIPPINVPENSRGPFPQVLVMIRSDQDKKIEIRYSITGAGADQPPNDVFNIDPVTGKMSVTKPLDREDRASYHLKAHAVDINGNQMEPPIDLYIYVIDMNDNRPEFKNQVYNGSVAEGSKPGTSVMQVTAFDADDSTTANGLVHYRILSQTPHIPIPNMFTINGATGEISTIAAGIDREKVSQYTVIVQATDMEGNLNFGLSNTATALISISDINDNPPELDSKTFLGEVPENAVGVVVANLTVRDKDQPHTPNWNAVYRITGGDPLGHFTIRTDEITNDGRVIVVKPVDYERNGAFMLMVVVSNQAHLASGIPSSPSSSAGVTITVLDVNEAPVFPSNPKIIRFEEGVPADTTLATFAALDPDRFIQQTIRYSKLSDPANWLKINRTNGRITTTAVLDRESPYMKKNVYEATFLAVDNGSPPATGTGTLQIYLIDVNDNVPVLVPQEALVCERSRHGYPVNITASDLDSEPNAGPYVFELPSYPSSARRNWTISRLNGNYAQLKLRIPYLEAGMYRVPILVSDSGNPPLSNTSVLKVKVCPCDENGDCTVIGAVTVAGLGTGAIITILICIIILLSMVLFFVVWVKRREKERQTKPLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPESLDHIMSKPAGVRRVDERPVILESQYPVRPTVPHPGDIGEFITDGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLDSSSSGEQDYDYLNDWGPRFKKLADLYGGGGED
Protein: Brush border myosin IB (Q90748)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MGSKERFHWQSHNVKQSGVDDMVLLAKISEEAIVENLKKRFMDDYIFTYIGPVLISVNPFKQMPYFTDREIELYQGAAQYENPPHIYALTDNMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNEHERNFHVYYQLIEGASQEQRQNLGIMSPDYYYYLNQSDTYQVEGTDDRSDFLETMNAMQVIGIRGEDQQLVLQIVAGILHLGNISFREEGNYARVENADSLAFPAYLLGIDRDRLNDKITSRKMDSKWGGRSESITVTLNVEQAAYTRDALAKGLYARVFDFLVESINRAMQKPYEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIKWTQIQYFNNKVVCDLIENKLNPPGIMSVLDDVCATMHATGEGADQTLLQKLQAAVGTHEHFNSWSSGFVIHHYAGKVSYDVNGFCERNRDVLFTDLIELMQSSEYAFIRMLFPEKLDADKKGRPTTAGSKIKKQANDLVNTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGFAYRRIFHKFLQRYAILTPETWPSWRGDERQGVQHLLRSVNMDPDQYQMGRSKVFVKNPESLFLLEEMRERKFDGFARVIQKAWRRHIAIRKYEQMREEASSILYNFKERRRNSINRNFVGDYLGMEERPELRQFLAKRERIDFADSITKYDRRFKPIKRDFILTPKYFYLIGREKVKKGPEKGQIKEVLKKKVEIQAVSGVSLSTRQDDFFILHEKDAYNFLESIFKTELVSLLCKRYEELTRSKLRLNFQDTLQFRVKKEGWGGGGTRTVTFTRGQGDVAALKAGGKTLTVSIADGLPRNSKPTRKEVMQSKGGSRRPPPSRGVPPAPQGTYRNGAPQFPRGDGHAKRDTYTTPQKQARAPPATALPPQNASRRSKARPPSEQNMEFLNVPDQGVAGMQRRRSVGQRPPPASRPKPQPKAAVPRCQALYQYIGQDVDELSFNVGDVIDILLEDISGWWKGRLHGREGLFPGNYVQKI
Protein: B30.2/SPRY domain-containing protein (Q57YN7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein yippee-like
Sequence:
MFYSGWQFPTPQRLEGRGSDAQSGYLLQNSQNSSISFVHFLPSGDRRQLVRQRETGSRIHLKSDVSIHPNSGVFYFEVEVQFSGAAGGGGGGGGGGASEPALVIGVCRRSLPSNGLPGEEANSVGLFTSQRMVYANGKREGEVVRFPTGTRARSIAGNNVDSINGDAAASGENGTAEGEEQEGRRFRGLRVGDTVGCIVNLLDGTVRFTFNGEILDFTAVLSRRTPKHGYYAAVGVFRRVPPVAVRVIFPSVARQTPIPQPISATGAEKREDDEQRKAEPAVGSVLNEAASRGGYFNFDIDGYCEDVTKKLVLAHLLGKAKGPVVELKENECTCRDTSIVAAICKHLAARGMTSALSAFEKEQQELTCAKCGCGAEPPEKADAAIPKHVDPTSEMLGAGTYNRSNGDSLTSGTCTESESRTVTYSAHIRRLREDVGNGRMSAAVERTLSFGLVSPGVLEKVRSCVENVDALLPDFWGLLFFAQRCDILFLLRVTHLVELSFDTMQRRLEILLRNVSGEGSIGRNATEDAHEAETTTACPFTTAAELMEFAHRFLLEPMRSVASTIRQHRNSTTKGPWTSEVLAFGSFESSADEGTDSFEELAAHLFVSGRDSSWSGPEAPATLLVRHSVPNVPAPKSQQQRRIVQTLATLISHQRAVCARAERYHKPGMSYKWAEEWLVLVEDTRRECRTRCTSLLLHAIEDFNGALEHRLVVWTQRQQQRTRGVAFGGSLEQHGAPVVPSKSGGKEGENAAVETREVLFPSLRSAWRHVHAAAALEPLLQVVTKAFSDQLNRVVVNARLMAESISTKEPPSTFCKGPKRGILHSPELSVSGADKKVAESNGSSASSCEPSVGSRTAPVESERECVSNNSVCQKRMACYTDDLRMSFLYMKSVYRAVFA
Protein: Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase) (P0A6J1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of activated sulfate.
Interaction partners:
- Sulfate adenylyltransferase subunit 2
- Phosphoadenosine 5'-phosphosulfate reductase
- Sulfate adenylyltransferase subunit 1
- Sulfite reductase hemoprotein beta-component
- 3'
- Sulfate/thiosulfate import ATP-binding protein CysA
- Sulfite reductase flavoprotein alpha-component
- Sulfate transport system permease protein CysW
- Thiosulfate-binding protein
- Siroheme synthase
Sequence:
MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
Protein: Thiosulfate sulfurtransferase (TST) (EC 2.8.1.1) (Rhodanese RhdA) (Thiosulfate:cyanide sulfurtransferase) (Q9HUK9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the sulfur transfer reaction from thiosulfate to cyanide, thus converting cyanide to the less toxic thiocyanate. Contributes to P.aeruginosa survival under cyanogenic conditions, and thus provides the bacterium with a defense mechanism against endogenous cyanide toxicity. Is the main cytoplasmic rhodanese in P.aeruginosa, accounting for 90% of total rhodanese activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17098912}.
Interaction partners:
- Thiosulfate sulfurtransferase GlpE
- Probable sulfite or nitrite reductase
- Probable oxidoreductase
- Probable cystathionine gamma-lyase
- HDOD domain-containing protein
- Phosphatidylserine decarboxylase proenzyme
- Sulfite reductase
- Probable 3-mercaptopyruvate sulfurtransferase
- Adenosine 5'-phosphosulfate reductase
- cysteine desulfurase
Sequence:
MSVFSDLPLVIEPSDLAPRLGAPELILVDLTSAARYAEGHIPGARFVDPKRTQWGQPPAPGLLPAKADLEALFGELGHRPEATYVVYDDEGGGWAGRFIWLLDVIGHHHYHYLNGGLPAWIADAQALDREVPAPVGGPLPLTLHDEPSATREYLQSRLGAADLAVWDARNPSEYAGTKVLAAKAGHVPGAINFEWTAGMDPARALRIRADIAEVLEDLGITPDKEVITHCQTHHRSGFTYLVAKALGYPRVKGYAGSWSEWGNHPDTPVEV
Protein: Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] (Q9JIQ3)
Organism: Mus musculus (Mouse)
Function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10929712}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NR28}. Note=Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis. {ECO:0000250|UniProtKB:Q9NR28}.
Interaction partners:
- E3 ubiquitin-protein ligase XIAP
- Baculoviral IAP repeat-containing protein 3
- Baculoviral IAP repeat-containing protein 2
- Cytochrome c, somatic
- Baculoviral IAP repeat-containing protein 5
- Apoptotic protease-activating factor 1
- Cytochrome c, testis-specific
- Serine protease HTRA2, mitochondrial
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
- Caspase-9
Sequence:
MAALRSWVTRSVCSLFRYRQRFPVLANSKKRCFSELIKPWHKTVLTGFGMTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQLSQKAETKLAEAQTKELHQKAQEVSDEGADQEEEAYLRED
Protein: Uncharacterized RNA-binding protein C126.11c (O94403)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Minichromosome loss protein 1
- DNA primase large subunit
- DNA polymerase alpha subunit B
- DNA primase small subunit
- LisH domain-containing protein C1711.05
- Putative splicing factor C222.18
- DNA polymerase epsilon subunit B
- DNA replication licensing factor mcm2
- DNA polymerase subunit delta-2
- DNA polymerase epsilon catalytic subunit A
Sequence:
MAKRGNKKKQEAPLSLGKHTVGGRVGKPTNAKTGSALTSDKSLFDKRIVKQLKNNELFNRLTLPSQELRDGIVRENQTKPSNSNSQSNGAISIRGIAGPTNVVIENLAPGTSSDDVAATLLNFGEILNCQVNDSQGKVRASVRFSTLASAQQVVQKLDGVTADGFKLSCYIKKNSKKRRTQKK
Protein: Probable mannose-1-phosphate guanyltransferase (EC 2.7.7.13) (GDP-mannose pyrophosphorylase) (GTP-mannose-1-phosphate guanylyltransferase) (O60064)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cell wall synthesis where it is required for glycosylation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mannose-1-phosphate guanyltransferase
- Phosphomannomutase
- Dolichol-phosphate mannosyltransferase
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 3
- Probable eukaryotic translation initiation factor 2 subunit beta
- Uncharacterized protein PB2B2.11
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 2 subunit gamma
Sequence:
MISSAVILVGGPSRGTRFRPLSFDVPKPLFKIGGREMIYHHLAALSKIESVKDVFLVGFYDESVFKDFINEVASHFPSFNRIKYLREYNCLGTGGGLYHFRDQILKGHTSNVFVMHADVCCSFPLQELLNVHHEKKALVTLMATKVSKEDASNFGCLVEEPSTGRVLHYVDKPSSYLSNIISCGIYIFDASIFDEIKKAYERRLEEVEKQLRSLDEGMEDYLSLETDVLAPLCSDSSKAIYAYNTPEFWRQIKTAGSAVPANSLYLQKAYHDGTLPKPDTEAEIIQPVFIHPNAIVSKGAKIGPNVSIGARVRIEDGARIRNSIIQEDCEISANAVVLHSILSRHCKIGKWSRVEGSPTLPSQHSTTIMRNSVKVQAITVMGADCIVHDEVRVQNCLVLPHKEIKVGLVGEIVM
Protein: GH14454p (Twin of eyeless, isoform A) (Q9V490)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim22
- Paired box protein Pax-6
- Protein sine oculis
Sequence:
MMLTTEHIMHGHPHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTGVISAGVSVPVQISTQNVSDLTGSNYWPRLQ
Protein: Homeobox protein (D3ZSU5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037109, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- PBX homeobox 1.
- PBX homeobox 3
- Homeobox A10
Sequence:
MATTGALGNYYVDSFLLGADAADELGAGRYAPGALGQPQRQAAALAEHPDFSPCSFQSKAAVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE
Protein: Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) (Q07802)
Organism: Mus musculus (Mouse)
Function: Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold.
Subcellular location: Nucleus {ECO:0000269|PubMed:1915300}.
Interaction partners:
- Zinc finger protein 423
- Methylcytosine dioxygenase TET2
- LIM/homeobox protein Lhx2
- Zinc finger protein 521
- Paired box protein Pax-5
- CCAAT/enhancer-binding protein alpha
- Transcription factor E2-alpha
- CCAAT/enhancer-binding protein beta
- Peroxisome proliferator-activated receptor gamma
- CCAAT/enhancer-binding protein delta
Sequence:
MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM
Protein: FYD (Q9LHA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Sequence-specific DNA binding transcription factor
- Probable E3 ubiquitin-protein ligase RHC1A
- Protein SEEDLING LETHAL 1, chloroplastic
- THO complex subunit 4A
- Pumilio homolog 23
- SNF1-related protein kinase catalytic subunit alpha KIN11
- Serine/threonine-protein kinase AFC2
- RNA-binding
- AT2G34250 protein
- SecY protein transport family protein
Sequence:
MGETLITTLSMENYHPSTLLSMDSGAFTHEESERDMNGSLILTGPPDINLPLSSEARPSLLLWNEHCDILDVGLGPQLYEPEAVVHVPKVAKKYNKRVDSAWGAWLFFSFYFKPVLDEKSKSKLTRDSNGLSGYDKSDLQLDSFLVQHDMENMYMWVFKEKPENALGKMQLRSYMNGHSREGERPFPFSVDKGFVRSHRMQRKHYRGLSNPQCLHGIEVVYSPNLSVLSEDEKKKWTELTGRDVNFAIPAEASDYGSWRNLPNTEFEAERPLPLAKANGHTHLKKLNGTCLNLSTHSPDHAVDTVEVQLAGSNKRKRDCLALGNCDDSSSSEKSLDMKIHATELPWSNDFSGVMKNVYGPVTAAKTIYEDDRGFLIVMSLPFVDSGRVKVTWRNTPAHGIVKISCVSTACEPFIKRHDRTFKLTDPTPEHCPPGEFVREVSLPNRIPDDAKLEAYRDETGTTLEVLVPKHRMGPEEHEVRVCLRPFVLE
Protein: Encapsulin nanocompartment cargo protein EncD (Q1D9P3)
Organism: Myxococcus xanthus (strain DK1622)
Function: Cargo protein of a type 1 encapsulin nanocompartment. May help nucleate Fe atoms in the interior of the encapsulin nanocompartment (Probable). Present in about 47 copies/encapsulin nanocompartment.
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:25024436}. Note=Probably lies against the interior face of the nanocompartment. {ECO:0000305|PubMed:25024436}.
Interaction partners:
- Type 1 encapsulin shell protein EncA
- Encapsulin nanocompartment cargo protein EncC
- Encapsulin nanocompartment cargo protein EncB
Sequence:
MAKNSNPSAFDRDFGYLMPFLDRVAAAASDLEDASARAELTRLMVEEKARWQRIQELLGGAGGRGAAAPTPAREAPAEAPRLARGSADELHEAAPFATGLTVGSLRGSR
Protein: Ankyrin repeat domain-containing protein 13B (Q86YJ7)
Organism: Homo sapiens (Human)
Function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22298428}. Late endosome {ECO:0000269|PubMed:22298428}. Early endosome {ECO:0000269|PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
Interaction partners:
Sequence:
MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTEQ