wanglab/gogpt-training-data huggingface dataset:
Protein: PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) (Transcriptional repressor Par-4-like protein PAWR) (Q62627)
Organism: Rattus norvegicus (Rat)
Function: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity). {ECO:0000250}.
Interaction partners:
- SplA/ryanodine receptor domain and SOCS box containing 1
Sequence:
MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAAKSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDECPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRYKSTISAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR
Protein: Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321) (Q9NS75)
Organism: Homo sapiens (Human)
Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Cysteinyl leukotriene receptor 1
- Leukotriene C4 synthase
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein G
- Leukotriene B4 receptor 2
- Glutathione hydrolase 1 proenzyme
- Guanine nucleotide-binding protein subunit alpha-15
- Arachidonate 5-lipoxygenase-activating protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
- Guanine nucleotide-binding protein G
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
Protein: Rv2525c-like glycoside hydrolase-like domain-containing protein (P95028)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSVSRRDVLKFAAATPGVLGLGVVASSLRAAPASAGSLGTLLDYAAGVIPASQIRAAGAVGAIRYVSDRRPGGAWMLGKPIQLSEARDLSGNGLKIVSCYQYGKGSTADWLGGASAGVQHARRGSELHAAAGGPTSAPIYASIDDNPSYEQYKNQIVPYLRSWESVIGHQRTGVYANSKTIDWAVNDGLGSYFWQHNWGSPKGYTHPAAHLHQVEIDKRKVGGVGVDVNQILKPQFGQWA
Protein: 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase) (P13016)
Organism: Escherichia coli (strain K12)
Function: Involved in cell wall peptidoglycan recycling. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety. Is also involved in beta-lactamase induction.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:19309146}.
Interaction partners:
- Anhydromuropeptide permease
- Protein AmpE
- Beta-hexosaminidase
- Beta-lactamase
- D-alanyl-D-alanine carboxypeptidase DacB
- Murein tetrapeptide carboxypeptidase
- UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase
- Anhydro-N-acetylmuramic acid kinase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Sequence:
MLLEQGWLVGARRVPSPHYDCRPDDETPTLLVVHNISLPPGEFGGPWIDALFTGTIDPQAHPFFAEIAHLRVSAHCLIRRDGEIVQYVPFDKRAWHAGVSQYQGRERCNDFSIGIELEGTDTLAYTDAQYQQLAAVTRALIDCYPDIAKNMTGHCDIAPDRKTDPGPAFDWARFRVLVSKETT
Protein: Immunoglobulin domain-containing protein Y54G2A.25 (LAD-2 long isoform) (Neuroglian) (G5ECX2)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Plexin-2
- Semaphorin-2A
- Titin homolog
- Tyrosine protein-kinase src-1
- Contactin rig-6
- Ig-like domain-containing protein
- Zinc metalloproteinase nas-39
- Dystroglycan 1
Sequence:
MRLVIAQFLLITQVFAAQKNSIGPPKLLEQSGEEVWYHLDDEDLLKNRLTLRCEADENTDRYSWLKDGEPFVIDSEDVLWEKESQSGSIVFTKPHASHQGYYQCFASNIFGTALSNKMHLRLGSLEHFPKRDVKLLRVKEGESLTLNCTPPRGTPDPKIVWLYRSLDDSSVIETIRSRHITVDNEGHLHFSSVELSDGKATLVYECAATSPVLRGEYRSGDRIQLDIEPSQDKSHPVKKMSVSPSEVTVRAGGQLKLQCIFGGRPLPTIFWSKIDGELPKSRIKDLTSHESDFGRSLIVENVHPDDAGAYECRGRHLVHTVNVRVMAAPFWEFDPPRDISLPEESTGELECLAGGQPTPIITWSMNGKFLHELAEDSRRVLLDHGRILRVRNLNHDLDTGVYQCNASNPLGYVFANAFVHVRAHAPFFRMPAARHWKVVLHSTVVLDCDVDAAPEAMVRWVDADDRPLQVVEGKNKLFPNHTFMVYDVNSADEGLYYCNVSNKYGINRATNRLQVFKPTYFVRIPTPKRLILEAGETAEVFCEAVADPRLPIRYQWTINGKVLTESQYYEILPDRLRFRSVRGRHSGIIDCAAITDVDVKLASMQLIVKDVPAHPVVETAHCSERKATVKWVAASDHGDSIKKYIVEMFTDFKKNEWEVINEEVNVNKETFEVDITLTPWVNYTFRVVAVNSHGRSDMKIDGQPKEDWLTCQTRPSFPYTNPTGVKGEGTEPDNLVISWKPLDRYYWNAPNMQYLVRYKLDEPIHGWTEFLVEDSLANFTIIRDQPTFRKYLIQVQSVNSVGPSIVEPEIHHGWSGEDVPDEAPRDFHIDTQINFTTINFTWNPVDANTVNGHFVGYEIEYWKAENTIRKYSIKIPANSTYKVINSFHAVTNYSAHIRTRNKRLRSAPSDYVSFAMPEGPPGKVHNLRVYSVGSTAILLQWDAPLQPNGRIRGYFISFQNEKNETEETYVIHRQKHYLHEKSEPDTGYKVSVWAETRAGEGPVTLRPVRTWPARIPDAPIFRVKNISLDSFVVEWQPNNHSVWKMPGAAFFVNYTAESSKTWFQSEIIYLPYTEITIRNLKEDQKYFMQGIAKDGPRRSESVFLPIKTLNRDYANRLKEDSLRSAAWFIAVLGVLGIGLFTICLTFCCGNKNRQEKFAVRRKEIEIGHQQDNEEEKQFLEYQYGFKN
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I6ALV2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAQQQSAACQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKIHRIHRDSGDNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSNS
Protein: Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Q0IIF7)
Organism: Bos taurus (Bovine)
Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (By similarity). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome regulatory subunit 6B
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory subunit 8
- Proteasome 26S subunit, ATPase 1
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 4
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKMKNGMTVLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWVQMMRVLQQKLEAIEDDTVKETDSSSASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKESQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDLEDKKVNQQPKTGDKDSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
Protein: Flavohemoprotein (Flavohemoglobin) (HMP) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (EC 1.14.12.17) (P24232)
Organism: Escherichia coli (strain K12)
Function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7875569}. Note=Has also been found to localize into the periplasm, but spectral analysis revealed that biochemically active HMP is exclusively found in the cytoplasmic fraction.
Interaction partners:
- Iron-sulfur cluster repair protein YtfE
- HTH-type transcriptional repressor NsrR
- Anaerobic nitric oxide reductase flavorubredoxin
- Protein YiiM
- Nitric oxide reductase FlRd-NAD
- Anaerobic nitric oxide reductase transcription regulator NorR
- Cytochrome c-552
- Hydroxylamine reductase
- Uncharacterized protein YeaR
- Uncharacterized protein YgbA
Sequence:
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNAIAAYASNIENLPALLPAVEKIAQKHTSFQIKPEQYNIVGEHLLATLDEMFSPGQEVLDAWGKAYGVLANVFINREAEIYNENASKAGGWEGTRDFRIVAKTPRSALITSFELEPVDGGAVAEYRPGQYLGVWLKPEGFPHQEIRQYSLTRKPDGKGYRIAVKREEGGQVSNWLHNHANVGDVVKLVAPAGDFFMAVADDTPVTLISAGVGQTPMLAMLDTLAKAGHTAQVNWFHAAENGDVHAFADEVKELGQSLPRFTAHTWYRQPSEADRAKGQFDSEGLMDLSKLEGAFSDPTMQFYLCGPVGFMQFTAKQLVDLGVKQENIHYECFGPHKVL
Protein: GH06739p (Thin, isoform A) (Thin, isoform B) (Q7JUV6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQFEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGELPDPTSGQIMERCGVCSEKAYLSHCAHCEKKICEDCKSAHMDILRREITRFNSQIRRSLHRLQDSLAIIEKNTMSLQTNAISVTEEIDEIYQRITKAIKDRSDQLKGEIDRYLAVELRNLTTLKENLDLEITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLKTVEFLRHFEYENNDYSRRVRFLVSIDPNQLVMNLATFGDLNIAPHSTPSGGSVSSSHLAPPSALQPGLMRSKSDHRLATQFRQQEERSGYNDEPVLGGRKFGERPQRSATQANNDRYGRSGGDYDYENDYDNEGSSGRAGKSSRFRSRFVRSHQNDDSDSEQQQQQRQQELKERKDRVLDSEDVSRGQLSGIIRLSDCSRVVQRLADIGKEKKEKKSDAAAAAQAAVQAAIQAQKAAMQRQQQKNQQNAADEEELARQKRKNAGSSSTGGAATSTSSGGGDTASDQRVAALKNRGGEESDGSSNQAASPVRNSAASTTRAESKPPVSAQVAAVKKTQRSGSSDSSASTESSASSAAAAAVAATSTSATAAAPATSSSNSTSQNAKAPSSSRYSTARDTTAVPEKKPFVSRFLPQHSTASTTNGSADKKKAESSSSSEEETSSESESESEPETKAKSSATSSTTNTKSTPNSAASSTTAASSSTTSGSYRDRLEARRASRDDSSSTAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSSYTSRFLNKSKSSAIVTQPSLSTPTASFDEDATGTGDDSDSRYGTGRSRYLAMKERRTRLARSRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRYSGYGSSDLSRSRSSHALKSRDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWARYLKNKYGNKSSKDSAGSSGSARDTHAGSSTSSSAAASSSHAHGYGSGTSGSSGRSTASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSPTSPTVAAAVAAAGITGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVLSTVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSEFKGLEGVAIMSNGNILVCDRENHRVQVF
Protein: Menin (Q9VM47)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone-lysine N-methyltransferase trithorax
- Retinoblastoma-binding protein 5 homolog
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- PAX-interacting protein 1
- Protein dpy-30 homolog
- Armadillo segment polarity protein
- HL01030p
- Protein pangolin, isoform J
- ENL/AF9-related, isoform B
- Host cell factor
Sequence:
MSTITRSASASPMALNGVIDASLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQAAQAAAAAVAAGDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQTILSVVEKPKPHRQATREVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRLAISEDHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAICAALNISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREAIESARTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIANELIPYVMKTESSGHSARSILRDSEVFANLLRFYDGICQWEEDSLTPILHIGWAKPLVNNITKFDYDIRSQVVIKLPEDLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNNRMATKEEKSKNSELPTTLADLTAACGEKILNPDFLLQGGGQPFADQKQQPSGGESDNPELHNNNNNSNSNNNNNNHNADKKEAAATTTNATTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQLGKPQHKEAKKEETSDDYDPFEIMLKRPVITLYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVASRKVRGVEKHSATISATITAISSSSGDSVLSGVGGGGGSGSAVTGGASLASSSLGGDSIAASRPKRTRRE
Protein: Methane oxygenase PmoA (Q9A833)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- phosphoenolpyruvate--protein phosphotransferase
- phosphoenolpyruvate--protein phosphotransferase
- DUF4169 domain-containing protein
- Glutamate synthase large chain
Sequence:
MRLLAPATAVVFALLAAPSVLADPAIDKRVDAVFSDDAVILTEAGKTVLVYRTKPLDPATEPGRANYVSPLYAPDGTALTEDKPGDHPHHRGVWWAWMKVQANGKSVADGWYMKNLSYFVREKRFLGDAEGGGTLTLEVDWIVNSGPELAYVARETTKVTVRPLKAGARRVEFDTMITSRVEALGLGGSEDDRGFGGFSIRLVDPEHLTFSSGGKTIMPNGAAINAGAAMGFAWSGGSNAPAWTIGLTCKANGQAVTRWMLYNDRSMQNCVFPGRAPLILKKDQTLRLEETVVIRPAAKKKL
Protein: Dehydration-responsive element-binding protein 2A (OsDREB2A) (Q0JQF7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3' of the cis-acting dehydration-responsive element (DRE). Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366, ECO:0000269|PubMed:20049613}.
Interaction partners:
- Os09g0110400 protein
- Histone H4
- Histone H4
- Actin-related protein 5
- Os06g0255200 protein
- Os02g0116900 protein
- Os07g0172500 protein
- FACT complex subunit SSRP1-A
- FACT complex subunit SSRP1-B
- Proliferating cell nuclear antigen
Sequence:
MERGEGRRGDCSVQVRKKRTRRKSDGPDSIAETIKWWKEQNQKLQEENSSRKAPAKGSKKGCMAGKGGPENSNCAYRGVRQRTWGKWVAEIREPNRGRRLWLGSFPTALEAAHAYDEAARAMYGPTARVNFADNSTDANSGCTSAPSLMMSNGPATIPSDEKDELESPPFIVANGPAVLYQPDKKDVLERVVPEVQDVKTEGSNGLKRVCQERKNMEVCESEGIVLHKEVNISYDYFNVHEVVEMIIVELSADQKTEVHEEYQEGDDGFSLFSY
Protein: Rab11 interacting protein, isoform A (Q9VWS3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.
Interaction partners:
- Rab11
- Dilute class unconventional myosin, isoform C
- AT21416p
- Nuclear fallout, isoform J
- Ras-related protein Rab5
Sequence:
MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPDQGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYDRPRAKWFKLESKPGKEKKNKERGELEVRIAFVVKSGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLHIRSKKKNQEAGADDSSSFGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEADPGVISEDEDEFVFDNLSHKSSGSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVGSGSAKGKQAVLPATLDEDASIDAEMEQLELDFSVRAHARANANASASGNASTLPPPSKPPRIPLSQVDEQPAAGSLEREKPKEKPAEVESDKDEWASKLYGGGKYLEIGSSNSLKRRSWEDRVPLPASVEEPPPLHSSSSSSSSSSDSDDDDEKPPQAAPPPVPVPASLPVPSAAASTASADPVVATSSSLFSPDVEHRNFDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPKPQPRATADLRAEEEKAKEEAARQLRAEEDARLEAELRLNEERLREEEEAMQRELEEEKERQKQLQMDEQQRREAKRWEEDQRLLSFAKRSTSLEEPVPEKQELKHERELVAKQEPEKTLDTAEPEPEHNFLTPEQSPKEFQTNGSGSGSGERWEKRLGKFKYGNKRDKYNNDNDSNSPSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEGKSREELMLIANGMENEALLQRQRVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKRYGTWSFWSSSRTRATPTH
Protein: Ankyrin repeat and SOCS box protein 5 (ASB-5) (Q8WWX0)
Organism: Homo sapiens (Human)
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity).
Interaction partners:
Sequence:
MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
Protein: adenosine deaminase (EC 3.5.4.4) (Q9VVK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- purine-nucleoside phosphorylase
- Adenosine receptor, isoform A
- Adenosine kinase
- Adenosine kinase
- Adenosine kinase
Sequence:
MSPVIRRNLIACLTLGLCVCLSFGPGPVESRTRPKNQVDRKLLTIYGSTPHVEALLGPGRPTPDTYKTLRSAFFRYEESRSLGHDLDLNSREIKANETIMKAKLKEFDEGLVTPHLFKPSQHIFDVLDGIRNTDLFKLLKKMPKGAVLHAHDTALCSTAAIINLTYYEHLWSCQQDGDLSASALRFSKDKPQALSDCDWSLLSDVRAKYGADKVDDYLAERLTLYPTKKFEDNNAAWSTFMSIFNLLDGLVMYAPVWADYYYKALEEFYEDGVLYLEFRSVVPTLYDMDGTEFTPMDTVRIYVETLEKFKEAHPDFIGSRMIYAPIRYTNAEGVTGYIQTLKQIKEKYPEFVAGFDLVGQEEMGRPLRDFVDELLSIPDDIDFYFHAGETNWFGSTVDENLIDAILLGTKRIGHGFGLVKHPVVLDMLKKLNVAIEVNPISNQVLQLVSDFRNHPCSHFFADGYPVVISSDDPSFWKATPLTHDFYIAFLGIASQHSDLRLLKKLALNSIQYSSLTGDAQFEALEKWQVKWDQFIADVNDRSSNRGSPSQRID
Protein: FhuB protein (Q8Y5U7)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- FhuC protein
- FhuG protein
- Lmo2182 protein
- Lmo2429 protein
- Lmo1959 protein
- Lmo0541 protein
- Lmo2431 protein
- Lmo1073 protein
- High-affinity heme uptake system protein IsdE
Sequence:
MDKSKQIKMNTRPTVAKFILSGGLLLLLILALFGIAVGAADINLSTVWDALFHYNSSDTQHQIIRSLRVPRVVADMAVGAAFAVAGAIMQGITRNPLADSGLLGLNAGSTFMVAVCFAFMPWLSYNSLILFSFVGAAIGAFLVFGVSSLAGSAMSPTRLVLAGAAVSSLLTALSEGLAIYFQLSQDLAFWYAGGVAGVKWSQLAAIWPWLLGALIAAILLSKSITILSLGDDIAVGLGEKTTFVKIASMVVVLILAGLAVSVVGPVGFIGLIVPHLVRFLVGVDYRWIIPCSAVVGAFLTLAADILARTINPPYETPISVIFALIGVPFFLYVARKERRNL
Protein: RCG32667 (A6HIS0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGATKEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSMSQEAQRG
Protein: Nuclear receptor subfamily 2 group F member 6 (COUP transcription factor 3) (COUP-TF3) (V-erbA-related protein 2) (EAR-2) (P43136)
Organism: Mus musculus (Mouse)
Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12690040}.
Interaction partners:
Sequence:
MAMVTGGWGDPGGDTNGVDKAGGSYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALPGPAACSPPGATGVEPFTGPPVSELIAQLLRAEPYPAAGRFGGGGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSG
Protein: Nuclear factor I B (A0A1B0GVN4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQYSAMDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASPTATTYTASGTSQANRYVGLSPRDPSFLHQQQSWYLG
Protein: Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] (P01193)
Organism: Mus musculus (Mouse)
Function: Stimulates the adrenal glands to release cortisol.
Subcellular location: Secreted {ECO:0000269|PubMed:25707796}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000269|PubMed:25707796}.
Interaction partners:
- Mu-type opioid receptor
- Melanocyte-stimulating hormone receptor
- Adrenocorticotropic hormone receptor
- Melanocortin receptor 3
- Melanocortin receptor 4
- Melanocortin receptor 5
- Melanocortin-2 receptor accessory protein
- Kappa-type opioid receptor
- Proenkephalin-B
- Pro-neuropeptide Y
Sequence:
MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ