Protein: Unconventional myosin-IXa (Unconventional myosin-9a) (Q8C170)
Organism: Mus musculus (Mouse)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z1N3}. Synapse {ECO:0000269|PubMed:27259756}. Cell projection, growth cone {ECO:0000269|PubMed:27259756}. Note=Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction (PubMed:27259756). {ECO:0000250|UniProtKB:Q9Z1N3, ECO:0000269|PubMed:27259756}.
Interaction partners:
- Transforming protein RhoA
- Rho-related GTP-binding protein RhoV
- Cell division control protein 42 homolog
Sequence:
MNVSDGGRRRFEDNEHTLRIYPGTISEGTIYCPIPARKNSTAAEVIDSLINRLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEQDTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGKRHIQRKSGHDDTTPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTGIRQSRLPASNTSLLDKDGIFAHSASSKLLERAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPQHIIPSKFNIQDFFRKININSDNYQVGKTMVFLKEHERQHLQDLLHQEVLRRIVLLQRWFRVLLSRQQFLHLRQASIIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQASWRAHLERQRYLELRAAAVIIQQRWRELYRCRHKAATCIQSRWRGYRQRKKYKEQRNKIILLQSIYRGFRARQRCNALKEEKLREAKLEHGLVHVKACGPLEIQGSDPSEWEDRSFDNRVKAIEECKYVIESNRISRESSMDFSKESPDKQQERGRRQSGTDLQEDVIVRQRPKSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGMSPSEERRWSTELMPEGLQSPHGTPDSESSQGSLELLTCDENQKSKPESLILDEGELKISSPNTFTNPKSQDNALSASSETSSTLAGKGASSDSEHLKNGTAKEKLVCSSEPITCKPQLRDSFVSSSLPTFFYIPHQEALKTSSHLDTSIQRNKLPEREAILKTTLTQDINREARKCQFSGDQMTPLNTDSSCTVLKKLEKLNIEKEKRQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEQSRTEASVLAPSFYQPRQKVERPCSLYIQNTPSKGEAGVLGSPSAVTKRDAALATKDSPSIHLPPKDRPVTLFFEKKGSPCQSRTVKELPKTERTGTQHDAAYKLSNNRSTERDHFKSTHFYSHRSDDPSREGSSRAIFFTPKDNITPLVHSGNPQAHKQDESAWKPKLAGPGQQETSQRFSSVDEQAKLHKAMSQGEITKLAVRQKASDLDIRPQRAKMRFWAKGKQGEKKTTRVKPASQSEISSFFPGPDVTPAHPFSDELTQYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRGVKISSVALDSMHWQNDSVQIIASASDLKSMDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSSYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQRDWNESPVRVWVNTFKVFLDEYMNEFKTLDSTAPKVLKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRAVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRIHRGNYPSPSSPVIVRLPSMSDVPEETLSSETAMETDLTDQQQAAMQQEEKVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMDSEERSLALSSLKAAGKSEPSSKSRKQLRKQPDSLDSVSSSVSSCLSNTTSSHGTRKRFQIYSKSPFYRAASACEAQGTEGPLGQAKSLEDRPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVTSGRKKTVDSDCSSTQQLPLFGNNEFMV