wanglab/gogpt-training-data huggingface dataset:
Protein: Peroxidase 53 (Atperox P53) (EC 1.11.1.7) (ATPA2) (Q42578)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Interaction partners:
- SUPPRESSOR OF GAMMA RESPONSE 1
- Serine/threonine-protein kinase ATR
- Flavone 3'-O-methyltransferase 1
- F5F19.5 protein
Sequence:
MAVTNLPTCDGLFIISLIVIVSSIFGTSSAQLNATFYSGTCPNASAIVRSTIQQALQSDTRIGASLIRLHFHDCFVNGCDASILLDDTGSIQSEKNAGPNVNSARGFNVVDNIKTALENACPGVVSCSDVLALASEASVSLAGGPSWTVLLGRRDSLTANLAGANSSIPSPIESLSNITFKFSAVGLNTNDLVALSGAHTFGRARCGVFNNRLFNFSGTGNPDPTLNSTLLSTLQQLCPQNGSASTITNLDLSTPDAFDNNYFANLQSNDGLLQSDQELFSTTGSSTIAIVTSFASNQTLFFQAFAQSMINMGNISPLTGSNGEIRLDCKKVNGS
Protein: Purple acid phosphatase 3 (EC 3.1.3.2) (Q8H129)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Nudix hydrolase 23, chloroplastic
- Bifunctional riboflavin kinase/FMN phosphatase
- Calcineurin-like metallo-phosphoesterase superfamily protein
- Purple acid phosphatase 4
- Purple acid phosphatase 7
- FAD synthetase 1, chloroplastic
- Purple acid phosphatase 8
- Flavin mononucleotide hydrolase 1, chloroplatic
- Purple acid phosphatase 17
- Riboflavin synthase
Sequence:
MTYIYRDTKITTKSTIPFLIFFLFCFSNLSMATLKHKPVNLVFYVYNLIIIFSSHSSTAELRRLLQPSKTDGTVSFLVIGDWGRRGSYNQSQVALQMGEIGEKLDIDFVISTGDNFYDNGLTSLHDPLFQDSFTNIYTAPSLQKPWYSVLGNHDYRGDVRAQLSPMLRALDNRWVCMRSFIVNAEIVDLFFVDTTPFVDKYFIQPNKHVYDWSGVLPRQTYLNNLLKELDVALRESVAKWKIVIGHHTIKSAGHHGNTIELEKHLLPILQANEVDLYVNGHDHCLEHISSVDSNIQFMTSGGGSKAWKGGDVNYVEPEEMRFYYDGQGFMSVHVSEAELRVVFYDVFGHVLHHWKKTYKEALYFAS
Protein: D(1A) dopamine receptor (Dopamine D1 receptor) (P21728)
Organism: Homo sapiens (Human)
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Cell projection, cilium membrane {ECO:0000269|PubMed:23936473}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61616}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61616}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250|UniProtKB:P18901}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Neuron-specific vesicular protein calcyon
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
- VIP peptides
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide
- Protein O-mannosyl-transferase TMTC1
- Thyrotropin subunit beta
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
Protein: Galanin receptor 2b (E7F7V7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for the hormone galanin. Receptor for the hormones spexin-1 and spexin-2.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Galanin peptides
- Spexin prohormone 1
- Galanin peptides-like precursor
Sequence:
MSDHEDLNKAMGHWNASESYQLNPASVIVSVVFSLIFLLGTIGNSLVLAVLLRSGQVGYNTTNLFILNLSVADFFFIIFCVPFQATIYSLEGWVFGSFMCKVVHFFINLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPCNAVVAMVVIWGLSLVFAGPYLSYYDLIDFENSNVCVPGWEEHNRKVLDTCTFVFGYVIPVLIVSLSYTRTIKYLWTAVDPLDGMSESKRAKRKVTKMIIIVTVLFCICWLPYHVVILCYLYGDFPFNQTTYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGFKKVFSCILSKKGRNKVHVVNVANTVPGFEAGSTEVSQMNEENARQNESEMVNRPLAQPQDTTMTITLPFQNQP
Protein: Equilibrative nucleoside transporter 1 (Equilibrative nucleoside transporter 3) (G5EDJ3)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Adenosine kinase
Sequence:
MSSAVELQPLNKTKKVEEESPEPEDKGNLVFYIILLHGIGTLMPWNMLITISYDYFESYKMLANSTIDMDTGVVTGYPTVYSSNFQSFQTIASQVPNLLLNLLNIFIVVKGGLASRITVGLSIVAVCVITTMMFIYVETSTWLTGFFTLTIITIIVLNGANGVYQNSIFGLASELPFKYTNAVIIGNNLCGTFVTLLSMSTKAVTRNILDRSFAYFSIALITLVFCFISFHILKKQRFYQYYSTRAERQRNKNDEAVDSEGKVANYIATFKEAFPQLINVFLVFFVTLSIFPGVMMYVKDEKKGGVYDFPLPQKYFMDVTTFLQFNVFAFIGSIVAGRKQWPAPNKLWIPVYLRLLYIPFFIFCNYLPETRSLPVFFESTWLFVIIAASMSFGSGYFSGLAMMYTSKTVDPSKAQVAGMMAGFFLISGIVSGLIFTMVIKMVVTA
Protein: Lamin tail domain-containing protein 2 (Q0VET5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAPKSCQESEDKQVSPAPAGVQPDSSDLGSPVGTPVDRVAPSYSQSAKLYTSTPMGCSVKQQLAPETLDPRTLRLLWEQRELEIQALRWAVQNGHNARYSSILQEVAGVPSERNSKSQDKFLRNQVQKLTLELKAQKEQAQQEKQQLEEKLQQNLWAKQQLEAELQTFQKSCLLQLARSSWVGRVLRSQTGSVEVVTTEVLRDPSDFSESAEIPTSGEGFPLEDVDWNSIAQRYPNLFSNLNFYSDQKQSQPPTSETYTLDSEGATKHTEKPTKILEWSALPLLDTSSSERTQSDTSSCPIALHSGAKKTTGHPSQGTNLASSEQMQEHTRSFSGYTEDLCKSHSPSCSKTVLESYTDLHHPYTRPQLNPFGCCLKIAAVSHREKFIRVINQSQAETIDLGGFVLQQLVRDFPVCMYRFPPGTLLAPQHHITVWGEGTSRTKKQLPVASGQDPFQFQSSRGCVTVLVNPQGQVLSEHQATPCVTLGSKIFTDNTDWSIDCFPLSESEPDVHPGEQQCRPSSPQKGRAKDAGARRKKPGPGVRQHRHSSTSGLRASRTLHPTETRDILPLLSSRKLLPSGEVLTQQEGVKAETSELLPVIPECPSRLCLGEDSLGRQEYKVQVCRKSVDLSCPMVALSVQNTAESRYGFRFLCYPPITEELCRRL
Protein: Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial] (Q86TL0)
Organism: Homo sapiens (Human)
Function: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system (By similarity). Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (By similarity). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy.
Subcellular location: [Cysteine protease ATG4D]: Cytoplasm {ECO:0000269|PubMed:19549685}.; SUBCELLULAR LOCATION: [Cysteine protease ATG4D, mitochondrial]: Cytoplasm {ECO:0000269|PubMed:19549685}. Mitochondrion matrix {ECO:0000269|PubMed:19549685, ECO:0000269|PubMed:22441018}. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000269|PubMed:22441018}.
Interaction partners:
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Gamma-aminobutyric acid receptor-associated protein
- Ubiquitin-like-conjugating enzyme ATG3
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Microtubule-associated protein 1 light chain 3 beta
- Ubiquitin-like-conjugating enzyme ATG10
- Microtubule-associated protein 1 light chain 3 alpha
Sequence:
MNSVSPAAAQYRSSSPEDARRRPEARRPRGPRGPDPNGLGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFSKISSIHLCGRRYRFEGEGDIQRFQRDFVSRLWLTYRRDFPPLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGLGPPELSGSASPSRYHGPARWMPPRWAQGAPELEQERRHRQIVSWFADHPRAPFGLHRLVELGQSSGKKAGDWYGPSLVAHILRKAVESCSDVTRLVVYVSQDCTVYKADVARLVARPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFETLCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPSSEDFVFL
Protein: Cadherin domain-containing protein (Q3USI1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MLRMRTTGWARGWCLGCCLLLPLCFSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGSGEGRRLGPADSAPYPGGGGNSASGGGSGGSKRRLDAPEGGGGTSPSGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRATDLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLVVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGTFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYAFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIVRSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVMMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTSNKYSKQMRVHPYITVFG
Protein: Protein transport protein SEC61 (Sec61 complex subunit SEC61) (Sec61 complex subunit alpha) (P32915)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. In an initial step, the signal sequence seems to bind simultaneously to SEC61 and SEC62. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC61 mediates the association with the ribosome.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Sec sixty-one protein homolog
- Translocation protein SEC62
- Protein translocation protein SEC63
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1
- Translocation protein SEC66
- Protein transport protein SSS1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
- Translocation protein SEC72
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Sequence:
MSSNRVLDLFKPFESFLPEVIAPERKVPYNQKLIWTGVSLLIFLILGQIPLYGIVSSETSDPLYWLRAMLASNRGTLLELGVSPIITSSMIFQFLQGTQLLQIRPESKQDRELFQIAQKVCAIILILGQALVVVMTGNYGAPSDLGLPICLLLIFQLMFASLIVMLLDELLSKGYGLGSGISLFTATNIAEQIFWRAFAPTTVNSGRGKEFEGAVIAFFHLLAVRKDKKRALVEAFYRTNLPNMFQVLMTVAIFLFVLYLQGFRYELPIRSTKVRGQIGIYPIKLFYTSNTPIMLQSALTSNIFLISQILFQKYPTNPLIRLIGVWGIRPGTQGPQMALSGLAYYIQPLMSLSEALLDPIKTIVYITFVLGSCAVFSKTWIEISGTSPRDIAKQFKDQGMVINGKRETSIYRELKKIIPTAAAFGGATIGALSVGSDLLGTLGSGASILMATTTIYGYYEAAAKEGGFTKNLVPGFSDLM
Protein: Eukaryotic translation initiation factor 4 gamma 2 (A0A8I6A1T4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGRNDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEAVVTEYLNSGNANDAVSGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
Protein: Sporulation kinase A (EC 2.7.13.3) (Stage II sporulation protein F) (Stage II sporulation protein J) (P16497)
Organism: Bacillus subtilis (strain 168)
Function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP.
Interaction partners:
- Sporulation initiation phosphotransferase F
- Stage 0 sporulation protein A
- 3-dehydroquinate dehydratase
- Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit B
- Transcriptional regulatory protein ResD
- Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
- Uncharacterized transcriptional regulatory protein YclJ
- Transcriptional regulatory protein YvrH
- Uncharacterized transcriptional regulatory protein YrkP
Sequence:
MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAERTEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK
Protein: Auxilin-related protein 1 (Auxilin-like protein 1) (Q9SU08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes uncoating of clathrin-coated vesicles. May interact directly with clathrin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11701884}; Peripheral membrane protein {ECO:0000269|PubMed:11701884}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:11701884}. Endoplasmic reticulum {ECO:0000269|PubMed:11701884}. Cytoplasmic vesicle {ECO:0000269|PubMed:11701884}.
Interaction partners:
- SH3 domain-containing protein 1
- Clathrin heavy chain 2
- Clathrin heavy chain 1
- AP-5 complex subunit mu
- AP-2 complex subunit alpha-2
- Beta-adaptin-like protein B
- Coatomer subunit beta'-1
- TOM1-like protein 4
- Coatomer subunit beta'-2
- Gamma-interferon-responsive lysosomal thiol protein
Sequence:
MDDFTGLLARDFGLKPQGKSAPMASQSNSSAADFNTFASSYSFATAAGKKSDSLPVFDDPGRDGDDLLFKDVFSGPPPPKYGSSSGDSRSPSAPAFDYDAMFKEPKSKSASSMPVYDKPVYDDEDVFESIPELKIPSTSSQSARFENVFSSISSSPTKHRKQNSSPFDDLMGNNLGKKGADSDREEKGSSIFDDLIPGFGRTSSPPSKRTTSETTNQSEKAPYRTAETSSNVEEDPFVVLEESESTPREPSRTDPLDDIGKFNSRKTDHSSVHGGVFVDIDPLDNLGKPGPDMNSKGKSHLRPPGNISGSQSPPVESPGSYHSKKVSFEDFLEPHNMSTPPPTNSNGSFESSDDVWLTVSEIPLFTQPTSAPPPTRPPPPRPTRPIKKKVNEPSIPTSAYHSHVPSSGRASVNSPTASQMDELDDFSIGRNQTAANGYPDPSSGEDSDVFSTAAASAAAMKDAMDKAEAKFRHAKERREKENLKASRSREGDHTENYDSRERELREKQVRLDRERAEREAEMEKAQEREKEEREREQKRIERERERLVARQAVERATREARERAATEAHAKVQRAAVGKATDARERAERAAVQRAHAEARERAAAGARDKAAKAAAEAREKAEKAAAEAKERANAEAREKETRVRAERAAVERAAAEARGRAAAQAKAKQQQENTNDLDSFFSSISRPNSAPRQRTNPLDPFQDSWNKGGSFESSRESLRVPPGQPENLRKTSSVTNIVDDLSSIFGASASQSGGFQDVDGETEERRRARLERHQRTQERAAKALAEKNERDLQVQREQVEKDRIGVTLDVEIKRWGAGKEGNLRALLSTLQYVLWPECGWQPVSLTDLITAASVKKVYRKATLCIHPDKVQQKGANLQQKYIAEKVFDMLKEAWNKFNSEELF
Protein: F-box only protein 11 (Q7TPD1)
Organism: Mus musculus (Mouse)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q86XK2}. Chromosome {ECO:0000250|UniProtKB:Q86XK2}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- F-box/LRR-repeat protein 14
- Denticleless protein homolog
- F-box/SPRY domain-containing protein 1
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- MDS1 and EVI1 complex locus
- Cullin-associated NEDD8-dissociated protein 1
Sequence:
MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPPQPPQQPPQQQPPPPPQQQPPPPPPPPPPPPQDRNNAGERDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN
Protein: Transcription factor atf21 (P78962)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Mitogen-activated protein kinase sty1
- Mitogen-activated protein kinase spk1
- Uncharacterized oxidoreductase C22A12.17c
- Zinc finger protein rsv2
- Histone H4
- Zinc finger protein rsv1
- Transcription factor ste11
- Transcription factor atf31
- AP-1-like transcription factor
Sequence:
MDFANVYLGLDTLGNEGYGASVSNGTHHDFHFNFNTFRDGGNHEVGEKRAESSDIGVYECRGPVQGPKDQTSFPSNSHNNYASIVGDASIGHYLKGPERTSEVSLPQTVNLSEISNNNDKGQPTNTPPVRSTIVAPSLYSEGSTLNHYNNGSHQVLHPQFQNGTNAPYVVQSNLMQNNVNLTGAEQEKGLDLYKNSATANNDEIFYNLESLRREGYLNSNKKQSQSPNGDYNSSDESCSNKTVASSQRRGTPGSNNVHTASNNETPDMKRRRFLERNRIAASKCRQKKKLWTQNLEKTAHIACEQSKALRILVSQLREEVICLKNQLLAHQDCNCEGIRQYLSSEAQGIMSFQKH
Protein: Transcription elongation factor GreB (Transcript cleavage factor GreB) (P30128)
Organism: Escherichia coli (strain K12)
Function: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.
Interaction partners:
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit alpha
- RNA polymerase-binding transcription factor DksA
- DNA-directed RNA polymerase subunit omega
- Transcription termination/antitermination protein NusG
- Transcription-repair-coupling factor
- RNA polymerase sigma factor RpoD
- Transcription termination factor Rho
- Transcription antitermination protein RfaH
Sequence:
MKTPLVTREGYEKLKQELNYLWREERPEVTKKVTWAASLGDRSENADYQYNKKRLREIDRRVRYLTKCLENLKIVDYSPQQEGKVFFGAWVEIENDDGVTHRFRIVGYDEIFGRKDYISIDSPMARALLKKEVGDLAVVNTPAGEASWYVNAIEYVKP
Protein: Stellate protein CG33238 (Q7KV14)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
Interaction partners:
- Casein kinase II subunit alpha
- Stellate protein CG33243
- Casein kinase II subunit beta
- Segment polarity protein dishevelled
- Stellate protein CG33246
- Stellate protein CG33237
- Stellate protein CG33247
- Stellate protein CG33236/CG33240/CG33244/CG33245
- Stellate protein CG33239/CG33241
- Ste:CG33242
Sequence:
MSSLENNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDEKKWYGMIHARYIRSERGLIAMHRKYLRGDFGSCPNISCYRQNTLPVGLSAVWGKSTVKIHCPRCKSNFHPKSDTQLDGAMFGPSFPDIFFSMLPNLTSPLDDPRT
Protein: MYB family conidiophore development protein FlbD (G5EAY5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- C2H2-type domain-containing protein
- BZIP-type transcription factor
- C2H2 type master regulator of conidiophore development brlA
- FlbE
- Protein fluG
- Conidiophore development regulator abaA
- Developmental regulator flbA
- SfgA
- Developmental regulatory protein wetA
Sequence:
MAPTHRRGPWVPEEDQLLLQLVREQGPNNNWVRISQHMHYRSPKQCRERYHQNLKPSLNRDPISAEEGLAIERMVNEMGRCWAEIARRLGNRSDNAVKNWWNGNMNRKKRGLQQSINSSPHSRTPHGRIEAPYHRASIGGTSPIFRSRLPSVSYDRPYTSWTSRSPISSRRESFSTASTFSRQLTPIYTLPALNRPVEAPLTSPAFSDTSNAPSLDPPSMVSDHNSVSSASPRTLPSPQLHSLPPLVDTRYPYGEVSRPQTSDDVYFSSFPGKSSGLFSDPKPRWAPEQRPCWASEEKVEPRRDSRMGLDNLLN