wanglab/gogpt-training-data huggingface dataset:
Protein: Accessory gland-specific peptide 95EF (Male accessory gland secretory protein 316) (P16548)
Organism: Drosophila melanogaster (Fruit fly)
Function: This protein may be a precursor of secreted proteins and peptide hormones.
Subcellular location: Secreted {ECO:0000269|PubMed:2109712}.
Interaction partners:
- Accessory gland protein Acp63F
- Accessory gland protein 98AB
- Accessory gland protein Acp32CD
- Accessory gland protein Acp76A
- Accessory gland protein Acp53Ea
- Accessory gland protein Acp36DE
- Accessory gland peptide Acp33A
- Accessory gland-specific peptide 26Aa
- Accessory gland protein Acp62F
- ACP53C14A
Sequence:
MASVKLFFIAILVVALSLNTSAAVLNPSSTAKPRFETKDRKLSAGALQSLAG
Protein: Delta-like protein B (DeltaB) (O57409)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Notch receptor 1b.
- Notch receptor 3.
- Neurogenic locus notch homolog protein 2 precursor
Sequence:
MAHLSLYCLLSVSLLQLVASSGVFELKVHSFSTTRRFCRRTRDCNIFFRICLKHSEDVISAEPPCTFGTGQTSVLRADQSSIASSAAIRVPFHFKWPGTFSLIIEAWNAESPKEHHDYTENQNNLISRLATRRRLAVGEDWSQDVHFGDQSELRYSYHVFCDEFYFGEACSDYCRPRDDTLGHYTCDENGNKECLVGWQGDYCSDPICSSDCSERHGYCESPGECKCRLGWQGPSCSECVHYPGCLHGTCSQPWQCVCKEGWGGLFCNQDLNYCTNHKPCANGATCTNTGQGSYTCTCRPGFGGTNCELEINECDCNPCKNGGSCNDLENDYSCTCPQGFYGKNCEIIAMTCADDPCFNGGTCEEKFTGGYVCRCPPTFTGSNCEKRLDRCSHKPCANGGECVDLGASALCRCRPGFSGSRCETNIDDCARYPCQNAGTCQDGINDYTCTCTLGFTGKNCSLRADACLTNPCLHGGTCFTHFSGPVCQCVPGFMGSTCEFPVQASLEKMAPRVGQTSPSAVAVSCVLGVLAVFLGVCVGLVVLRRRRHRLRRQQLCDSVFNDLETVNNLDRQHYPYDRDFSQVKPCNTEGRISLAASHTLPAGQEFLWSAGGGLR
Protein: Paxillin (F5H836)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}.
Interaction partners:
Sequence:
MAGNKDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPG
Protein: Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) (P70124)
Organism: Mus musculus (Mouse)
Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity).
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Albumin
- Thyroglobulin
- T-cell surface glycoprotein CD4
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-4
- Interleukin-5
- Interferon gamma
- Interleukin-13
- H-2 class II histocompatibility antigen, A beta chain
- Toll-like receptor 4
Sequence:
MDALRLANSAFAVDLFKQLCERDPAGNILFSPICLSTSLSLAQVGTKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLVKRLYIDKSLNPSTEFISSTKRPYAKELETVDFKDKLEETKGQINSSIKELTDGHFEDILSENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRISKTDTKPVQMMNLEATFCLGNIDDISCKIIELPFQNKHLSMLIVLPKDVEDESTGLEKIEQQLNPETLLQWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNESTSDFSGMSETKGVSLSNVIHRVCLEITEDGGESIEVPGSRILQHKDEFNADHPFIYIIRHNKTRNIIFFGKFCSP
Protein: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (Q5GA13)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASSVGNVADSTEPTKRVLSFQGLAELAHREYQSGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLANIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLMQSIPGMHNSEKFEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLAYPGTSGAPFMDYIVSDKATSPIEVAEQYSEKLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVVKMECDGQEVADSNGALSMPIIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATTQIFTVEEVVVSGTVALQINNKAATGEEVPRTIVVTTRSQYGLPEDSIVYCNFNQLYKIDPPTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNLGLPASRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQRICSPLFNTKQYTMDLEKLYLQMWENHASGGKPDHLVKMQSLETSEST
Protein: Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Lysophospholipid receptor C1) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) (Q9Z0L1)
Organism: Mus musculus (Mouse)
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha-12
- Sphingosine 1-phosphate receptor 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Sphingosine kinase 2
- Sphingosine kinase 1
Sequence:
MNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSEDGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAYVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLRGPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST
Protein: Transketolase (TK) (EC 2.2.1.1) (A0A0I9QGZ2)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, likely via a covalent intermediate with the cofactor thiamine pyrophosphate. Can use L-erythrulose as donor and D-ribose-5-phosphate as acceptor substrates, forming glycolaldehyde and D-sedoheptulose-7-phosphate. For synthetic purposes, is able to use hydroxypyruvate (HPA) as donor substrate, making the reaction irreversible due to the release of carbon dioxide, and various aldehydes as acceptor substrates, which leads to the corresponding ketoses. Thus, using hydroxypyruvate as donor and three different aldehydes as acceptors, i.e. glycolaldehyde, D-glyceraldehyde and butyraldehyde, the enzyme stereoselectively forms the corresponding products L-erythrulose, D-xylulose and (3S)-1,3-dihydroxyhexan-2-one, respectively.
Interaction partners:
Sequence:
MAHSIEELAITTIRTLSIDAIEKAKSGHPGMPMGAAPMAYTLWTKFMNHNPANPNWFNRDRFVLSAGHGSMLLYSLLHLSGYDVSMDDLKQFRQWGSKTPGHPEYGHTPGVEATTGPLGQGIAMAVGMAMAERHLAATYNRDGFEIINHYTYAICGDGDLMEGVASEAASLAGHLKLGRLIVLYDSNDISLDGELNLSFSENVAQRFQAYGWQYLRVEDGNNIEEIAKALEEARADLSRPTLIEVKTTIGYGAPNKAGTSGVHGAPLGAQEAKLTKEAYRWTFAEDFYVPEEVYAHFRATVQEPGAKKEAKWNEQLAAYEQAHPELAAQLKRAIEGKLPDGWEASLPVYEAGKSLATRSSSGEVINAIAKAVPQLFGGSADLASSNKTLIKGGGNFLPDSYEGRNVWFGVREFAMGAALNGMALHGGLKVFGGTFFVFSDYLRPAIRLAALMGLPVIYVLTHDSIAVGEDGPTHEPIEHLASLRAMPNLSVIRPADANETAAAWRLALESTDKPTALVLTRQDVPTLAATAELAYEGVKKGAYVVSPAKNGAPEALLLATGSEVGLAVKAQEALAAEGIHVSVISMPSWDRFEAQPKSYRDEVLPPAVTKRLAIEMGASLGWERYVGAEGDILAIDRFGASAPGEKIMAEYGFTVDNVVRRTKALLGK
Protein: FTO alpha-ketoglutarate dependent dioxygenase (A0A1B0GUY7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
CSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRG
Protein: Dynein axonemal assembly factor 4 (Dyslexia susceptibility 1 candidate gene 1 protein homolog) (Q5VJS5)
Organism: Rattus norvegicus (Rat)
Function: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WXU2}. Cytoplasm {ECO:0000269|PubMed:16989952}. Cell projection, neuron projection {ECO:0000269|PubMed:19423554}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6AZN0}.
Interaction partners:
- Doublecortin domain-containing protein 2
- PIH1 domain-containing 3.
- Dynein axonemal assembly factor 3
- Dynein axonemal assembly factor 1
- Leucine-rich repeat-containing protein 6
- Dyslexia-associated protein KIAA0319 homolog
- RuvB-like 1
- PIH1 domain-containing protein 2
- Dynein axonemal assembly factor 5
- RuvB-like helicase
Sequence:
MPVRVSEFSWQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWESLSMPGVDKEMMQRIREKSILQAQEKAKEATEAKAAAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATRELEAWKECQKKADGQKRVQRKEKPLQGKQAEERGALKPQSLPRKAPPTRLPTRGRNWENIFSEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFSDLKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTTLKSHD
Protein: Cholecystokinin (CCK) [Cleaved into: Cholecystokinin-58 (CCK58); Cholecystokinin-58 desnonopeptide ((1-49)-CCK58); Cholecystokinin-39 (CCK39); Cholecystokinin-33 (CCK33); Cholecystokinin-25 (CCK25); Cholecystokinin-18 (CCK18); Cholecystokinin-12 (CCK12); Cholecystokinin-8 (CCK8); Cholecystokinin-7 (CCK7); Cholecystokinin-5 (CCK5)] (P06307)
Organism: Homo sapiens (Human)
Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Subcellular location: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:37453717}.
Interaction partners:
- Gastrin/cholecystokinin type B receptor
- Cholecystokinin receptor type A
- C-C motif chemokine 28
- Gastrin
- Gastrin-releasing peptide
- Appetite-regulating hormone
- Somatostatin
- Neurotensin/neuromedin N
- Inactive tyrosine-protein kinase 7
- Protachykinin-1
Sequence:
MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS
Protein: Calcium homeostasis modulator protein 6 (Protein FAM26F) (Q5R3K3)
Organism: Homo sapiens (Human)
Function: Pore-forming subunit of a voltage-gated ion channel.
Subcellular location: Cell membrane {ECO:0000269|PubMed:32374262}; Multi-pass membrane protein {ECO:0000255}. Note=Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli. {ECO:0000250|UniProtKB:Q8C9E8}.
Interaction partners:
Sequence:
MEKFRAVLDLHVKHHSALGYGLVTLLTAGGERIFSAVAFQCPCSAAWNLPYGLVFLLVPALALFLLGYVLSARTWRLLTGCCSSARASCGSALRGSLVCTQISAAAALAPLTWVAVALLGGAFYECAATGSAAFAQRLCLGRNRSCAAELPLVPCNQAKASDVQDLLKDLKAQSQVLGWILIAVVIIILLIFTSVTRCLSPVSFLQLKFWKIYLEQEQQILKSKATEHATELAKENIKCFFEGSHPKEYNTPSMKEWQQISSLYTFNPKGQYYSMLHKYVNRKEKTHSIRSTEGDTVIPVLGFVDSSGINSTPEL
Protein: Lipase lipl-1 (EC 3.1.1.-) (Lipase-like 1) (Q93789)
Organism: Caenorhabditis elegans
Function: Lipase that, together with lipl-3, plays a role in the response to nutrient deprivation by controlling lipid metabolism. Specifically, involved in the breakdown of lipids during lipophagy, a process during which lipids contained in lipid droplets that have been delivered to lysosomes by autophagy are degraded.
Subcellular location: Secreted {ECO:0000269|PubMed:23604316}. Lysosome lumen {ECO:0000269|PubMed:23604316}. Note=Secreted into the intestinal lumen. {ECO:0000269|PubMed:23604316}.
Interaction partners:
- Lipase lipl-5
- Delta
- Delta
- Fatty acid synthase
- Helix-loop-helix protein 30
- Patatin-like phospholipase domain-containing protein atgl-1
Sequence:
MRSWSTVMLAVLATAATVFGHDADPEMKMTTPQIIMRWGYPAMIYDVTTEDGYILELHRIPYGKTNVTWPNGKKPVVFMQHGLECSSSNWVVNLPTESAAFLFADAGYDVWLGNFRGNTYSMKHKNLKPSHSAFWDWSWDEMQQYDLPAMIEKALEVTGQDSLYYIGHSQGTLTMFSRLSEDKVGWGNKIKKFFALAPVGSVKHIKGALKFFADYFSLEFDGWFDVFGSGEFLPNNWIMKLVSESVCAGLKVEAGVCDDVMFLIAGPESNQLNATRVPIYVAHTPAGTSTQNIVHWIQMVRHGGTPKYDYGEKGNKKHYGQANVPAYDFTTVNRPVYLYWGDSDWLADPTDVTDFLLTHLNPSTVVQNNKLIDYNHLDFIWGLRAPKDIYEPIIDIVRNDVLNGS
Protein: Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) (T-cell-specific kinase) (Q03526)
Organism: Mus musculus (Mouse)
Function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells. Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3.
Subcellular location: Cytoplasm. Nucleus {ECO:0000269|PubMed:15662016}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. {ECO:0000250}.
Interaction partners:
- Lymphocyte cytosolic protein 2
- Proto-oncogene vav
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- GRB2-related adaptor protein 2
- T-cell surface glycoprotein CD3 epsilon chain
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Tyrosine-protein kinase TXK
- Tyrosine-protein kinase HCK
- Growth factor receptor-bound protein 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLVYLQVVHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPSKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAEIAEAGL
Protein: Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) (P19332)
Organism: Rattus norvegicus (Rat)
Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P10636}. Cell membrane {ECO:0000250|UniProtKB:P10636}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10636}; Cytoplasmic side {ECO:0000250|UniProtKB:P10636}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P10636}. Cell projection, axon {ECO:0000250|UniProtKB:P10636}. Cell projection, dendrite {ECO:0000250|UniProtKB:P10636}. Secreted {ECO:0000250|UniProtKB:P10636}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P10636}.
Interaction partners:
- Glycogen synthase kinase-3 beta
- Cyclin-dependent kinase 5
- Amyloid-beta precursor protein
- Ig gamma-1 chain C region
- Caspase-3
- Tubulin beta-3 chain
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Tubulin beta-2B chain
- Tubulin alpha-1B chain
- Alpha-synuclein
Sequence:
MAEPRQEFDTMEDQAGDYTMLQDQEGDMDHGLKESPPQPPADDGSEEPGSETSDAKSTPTAEDVTAPLVEERAPDKQATAQSHTEIPEGTTAEEAGIGDTPNMEDQAAGHVTQEPQKVEIFSQSLLVEPGRREGQAPDSGISDWTHQQVPSMSGAPLPPQGLREATHQPLGTRPEDVERSHPASELLWQESPQKEAWGKDRLGSEEEVDEDITMDESSQESPPSQASLAPGTATPQARSVSASGVSGETTSIPGFPAEGSIPLPADFFSKVSAETQASPPEGPGTGPSEEGHEAAPEFTFHVEIKASAPKEQDLEGATVVGAPAEEQKARGPSVGKGTKEASLLEPTDKQPAAGLPGRPVSRVPQLKARVAGVSKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVHIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Protein: Protein REVERSION-TO-ETHYLENE SENSITIVITY1 (F4ITL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts at an early step in the ethylene signaling pathway. Positively regulates ETR1, leading to the negative regulation of ethylene responses.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17644624, ECO:0000269|PubMed:17999643}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:17644624, ECO:0000269|PubMed:17999643}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ethylene receptor 1
- Protein EIN4
- Ethylene response sensor 1
- Ethylene receptor 2
- Ethylene response sensor 2
- Protein RTE1-HOMOLOG
- Serine/threonine-protein kinase CTR1
- Ethylene-insensitive protein 2
- Protein ETHYLENE INSENSITIVE 3
- Protein AUXIN-REGULATED GENE INVOLVED IN ORGAN SIZE
Sequence:
MSRGRGVPMMDLKRSYDVEDRVVSVSIPSIIEADEADLWPLPEIDTKKSKFPCCIVWTPLPVVSWLAPFIGHIGLCREDGVILDFAGSNFINVDDFAFGPPARYLQLDRTKCCLPPNMGGHTCKYGFKHTDFGTARTWDNALSSSTRSFEHKTYNIFTCNCHSFVANCLNRLCYGGSMEWNMVNVAILLMIKGKWINGSSVVRSFLPCAVVTSLGVVLVGWPFLIGLSSFSLLLFAWFIIATYCFKNIIT
Protein: Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) (Q07869)
Organism: Homo sapiens (Human)
Function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Subcellular location: Nucleus.
Interaction partners:
- Retinoic acid receptor RXR-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear receptor coactivator 1
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- Period circadian protein homolog 2
- Transcription factor Jun
- Phosphatidate phosphatase LPIN1
- Solute carrier family 53 member 1
- Fatty acid-binding protein, liver
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Protein: ADP,ATP carrier protein 5 (ADP/ATP translocase 5) (O05962)
Organism: Rickettsia prowazekii (strain Madrid E)
Function: Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MLSTSPSRSFKNKFRAAFWPVHNYELGKFIPISALMFCILFNQNILRILKDSILISEISAEIAGFAKVYCVTPVAALFVIIYAKMINHLTFEKIFYYLSAFFISCFILFAFVIYPNIHIFHVHPDTLSDWMNKYPHFKWYISLVGNWGYIVYYSLAELWPNIFYVLLFWQFTNELTTTEEAKRFYTLFSLFGNSSLILVGFLMMNLSSEDTIIKKFISISDSKITLVQVSTTIIAIVAIICCLLVRFISKYIFTNPLFYHKTKSSRSTAQRMGLIKSFKYIVKSKYLWLLLICSAAFGFAINLVEAVWKAKIKELYPTVNTYAEFNSLYILWTGVAIIVMTIIGNNVMRMHNWFVAAVISPVIIMVTGVLFFGLIVFDQQILSLFDGAILMSPLALAVSIGGIQNILAKGTKYSIWDTSREMLYIPLDDELKTKGKAAVDVISAKVGKSSSGLVQSIIFTLVPNATFTSISPILMVVFTFVCFAWIYAVRKIYFEYQKIA