Protein: Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (AtSNC1) (Disease resistance RPP5-like protein) (Probable NAD(+) hydrolase SNC1) (EC 3.2.2.6) (O23530)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Disease resistance protein of the TIR-NB-LRR-type. Part of the RPP5 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. Expression regulated by MOS1 at chromatin level. Nuclear localization of SNC1 is essential for its activity. ABA deficiency can rescue high-temperature inhibition of SNC1-mediated defense responses.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21079790}. Microsome {ECO:0000269|PubMed:21079790}. Nucleus {ECO:0000269|PubMed:21079790, ECO:0000269|PubMed:22454454}. Note=Restricted to microsomes when interacting with SRFR1. Accumulates in nucleus at 22 degrees Celsius, but not at 28 degrees Celsius. Nuclear accumulation is enhanced by abscisic acid deficiency. {ECO:0000269|PubMed:21079790, ECO:0000269|PubMed:22454454}.
Interaction partners:
- Protein EDS1
- Negative regulator of systemic acquired resistance SNI1
- Topless-related protein 1
- F-box protein CPR1
- Importin subunit alpha-3
- Protein MODIFIER OF SNC1 1
- Protein BONZAI 1
- Regulatory protein NPR1
- Suppressor of RPS4-RLD 1
- Nuclear pore complex protein NUP88
Sequence:
MMDTSKDDDMEIASSSGSRRYDVFPSFRGEDVRDSFLSHLLKELRGKAITFIDDEIERSRSIGPELLSAIKESRIAIVIFSKNYASSTWCLNELVEIHKCYTNLNQMVIPIFFHVDASEVKKQTGEFGKVFEETCKAKSEDEKQSWKQALAAVAVMAGYDLRKWPSEAAMIEELAEDVLRKTMTPSDDFGDLVGIENHIEAIKSVLCLESKEARIMVGIWGQSGIGKSTIGRALYSKLSIQFHHRAFITYKSTSGSDVSGMKLRWEKELLSEILGQKDIKIEHFGVVEQRLKQQKVLILLDDVDSLEFLKTLVGKAEWFGSGSRIIVITQDRQLLKAHEIDLIYEVEFPSEHLALTMLCRSAFGKDSPPDDFKELAFEVAKLAGNLPLGLSVLGSSLKGRTKEWWMEMMPRLRNGLNGDIMKTLRVSYDRLHQKDQDMFLYIACLFNGFEVSYVKDLLKDNVGFTMLTEKSLIRITPDGYIEMHNLLEKLGREIDRAKSKGNPGKRRFLTNFEDIHEVVTEKTGTETLLGIRLPFEEYFSTRPLLIDKESFKGMRNLQYLEIGYYGDLPQSLVYLPLKLRLLDWDDCPLKSLPSTFKAEYLVNLIMKYSKLEKLWEGTLPLGSLKEMNLRYSNNLKEIPDLSLAINLEELDLVGCKSLVTLPSSIQNATKLIYLDMSDCKKLESFPTDLNLESLEYLNLTGCPNLRNFPAIKMGCSDVDFPEGRNEIVVEDCFWNKNLPAGLDYLDCLTRCMPCEFRPEQLAFLNVRGYKHEKLWEGIQSLGSLEGMDLSESENLTEIPDLSKATKLESLILNNCKSLVTLPSTIGNLHRLVRLEMKECTGLEVLPTDVNLSSLETLDLSGCSSLRSFPLISTNIVWLYLENTAIEEIPSTIGNLHRLVRLEMKKCTGLEVLPTDVNLSSLETLDLSGCSSLRSFPLISESIKWLYLENTAIEEIPDLSKATNLKNLKLNNCKSLVTLPTTIGNLQKLVSFEMKECTGLEVLPIDVNLSSLMILDLSGCSSLRTFPLISTNIVWLYLENTAIEEIPSTIGNLHRLVKLEMKECTGLEVLPTDVNLSSLMILDLSGCSSLRTFPLISTRIECLYLQNTAIEEVPCCIEDFTRLTVLMMYCCQRLKTISPNIFRLTRLELADFTDCRGVIKALSDATVVATMEDHVSCVPLSENIEYIWDKLYRVAYLQEHFSFRNCFKLDRDARELILRSCFKPVALPGEEIPKYFTYRAYGDSLTVIVPQSSLSQNFLRFKACVVVEPLSKGKGFYPFLKVNVGFNGKQYQKSFSKDAELELCKTDHLFFCSFKFRSEDLPSKLNFNDVEFKFCCSNRIKECGVRLMYVSQEENNQQTTRSEKRMRMTSGTSEEDINLPYGLIVADTGLAALNMELSLGQGEPSSSTSLEGEALCVDYMITEEQDKGIPILFPVSGN