wanglab/gogpt-training-data huggingface dataset:
Protein: Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) (Q8BYY4)
Organism: Mus musculus (Mouse)
Function: Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).
Interaction partners:
- snRNA-activating protein complex subunit 3
Sequence:
MALVGSRVELDADEDIFEDALETISRSPSDMATSGFHFVPCETKRTSRQLGASAMGRPEGSSAKVDLKSGLEECAEALNLFLSNKFKDALELLRPWAKESMYHALGYSTIVVLQAVMTFEQQDIQNGISAMKDALQTCQKYRKKCTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHVIQKNKQEQHFFYEFEGGVKLGTGAFNLMLSLLPARIIRLLEFIGFSGNRDLGLLQLREGASGSSMRSPLCCLTILAFHTYISLILGTGEVNVVEAESLLAPFLQQFPNGSLILFYHARIELLKGNTEKAQETFRKCISVQEEWKQFHHLCYWELMWIHIYQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEEVAATKENVVSLFRQVDGLKQRIAGKSLPTEKFAVRKARRYSPPSGVPGKLVMPALEMMYVWNGFSIVGKRKDLSENLLVTVEKAEEALQNQDFTDYSVDDECLVKLLKGCCLKNLERPLQAELCFNHVVESEKLLKYDHYLVPFTLFELAFLYKSQGEIDKAIKVLETARNNYKDYSLESRLHFRIQAALHLWKKPSTD
Protein: Pectin lyase-like superfamily protein (F4J3I0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable pectate lyase 20
- Plant UBX domain-containing protein 11
- Pectin acetylesterase 12
- Pectin lyase-like superfamily protein
- Classical arabinogalactan protein 9
- Probable pectate lyase 8
- Pectin acetylesterase 1
- Aquaporin TIP2-1
- Arabinogalactan protein 21
Sequence:
MMGSILLLLLFFSLVQSRSDTSYSKIQLPGDSLTLSVTDFGATGDGINYDTSAIQSTIDACNRHYTSFSSICRVVFPSGNYLTAKLHLRSGVILDVTENAVLLGGPRIEDYYPAETSSDWYVVVANNATDVGITGGGAIDGQGSKFVVRFDEKKNVMVSWNQTGACLGDECRPRLVGFVDSINVEIWNITLREPAYWCLHIVRCENTSVHDVSILGDFNTPNNDGIDIEDSNNTVITRCHIDTGDDAICPKTYTGPLYNLTATDCWIRTKSSAIKLGSASWFDFKGLVFDNITIFESHRGLGMQIRDGGNVSDVTFSNINISTRYYDPSWWGRAEPIYITTCPRDSSAKEGSISNLLFVNITIDSENGVFLSGSPNGLLSDIKFKNMNLTFRRWSNYSAGLVDYRPGCQGLVNHRATSGIIMEHVNGFRVENVDLKWSDDDDVNAAWNVPLEFRPSTVNNVSFVGFTSGLYTKLFESDYVMVGENNIAFA
Protein: F-actin-capping protein subunit alpha (Q7ZUR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MADFEEQLSDDEKVRIAANFVIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMGQFTPAKLDGSEDQVLITEHGDLGHGRFFDPRKKQSFKFDHLRKEASEAQSYEGEAALRPWRDAVDEALRAYVKEHYPSGVCTVYGKTIDGQKTIIACIEGHRFQPQNFWNGRCRSEWKFSISQATAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLVISTEVQTAKEFVEIIKNAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
Protein: Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) (Q9LVY1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transaminase involved in tyrosine breakdown. Converts tyrosine to 3-(4-hydroxyphenyl)pyruvate. Can catalyze the reverse reaction, using L-glutamate in vitro. Can convert phenylalanine to phenylpyruvate and catalyze the reverse reaction in vitro.
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Arogenate dehydrogenase 1, chloroplastic
- Homocysteine S-methyltransferase 3
- Homocysteine S-methyltransferase 2
- Homocysteine S-methyltransferase 1
- Arogenate dehydrogenase 2, chloroplastic
- Phenylalanine ammonia-lyase 1
- Phenylalanine ammonia-lyase 4
- Chorismate mutase 1, chloroplastic
- Phenylalanine ammonia-lyase 2
Sequence:
MGENGAKRWNFGANEVVERSNSLTIRDYLNTLINCLDGGDVRPVIPLGHGDPSPFPSFRTDQAAVEAICDAVRSTKFNNYSSSSGVPVARKAVAEYLSSDLSYQISPNDVHITAGCVQAIEILISALAIPGANILLPRPTYPMYDSRAAFCQLEVRYFDLLPENGWDVDLDGVEALADDKTVAILVINPCNPCGNVFSRQHLQKIAETACKLGILVIADEVYDHFAFGDKPFVSMAEFAELVPVIVLGAISKRWFVPGWRLGWMVTLDPHGIMKDSGFVQTLINVVNMSTDPATFIQGAMPDIIGNTKEEFFSSKLEMVKKCAEICYEELMKIPCITCPCKPEGSMFTMVKLNFSLLEDISDDLDFCSKLAKEESMIILPGQAVGLKNWLRITFAVELELLIEGFSRLKNFTERHSKNQP
Protein: Penicillin-binding protein 2D (PBP-2D) (PBP2d) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.99.28) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] (P70997)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the polymerization and cross-linking of spore peptidoglycan. May be required for synthesis of the spore germ cell wall, the first layer of peptidoglycan synthesized on the surface of the inner forespore membrane.
Subcellular location: Cell membrane; Single-pass membrane protein.
Interaction partners:
- Stage V sporulation protein D
- Stage V sporulation protein E
- Penicillin-binding protein 4B
- Sporulation-specific N-acetylmuramoyl-L-alanine amidase
- Stage II sporulation protein Q
- Probable peptidoglycan glycosyltransferase FtsW
- Penicillin-binding protein 2B
- Peptidoglycan glycosyltransferase RodA
Sequence:
MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQGAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHHGFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQNYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYSPYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDNAMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDPRTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETEFQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFGITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPNQHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWMIGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTGVYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKWWDKWLGRHH
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (D4A648)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ras association domain-containing protein 1
- Ras association domain-containing protein 5
- Protein salvador homolog 1
- MOB kinase activator 1A
- Serine/threonine-protein kinase 3
- Forkhead box protein O1
- Forkhead box O3
- Caspase-3
- Forkhead box O6
- Forkhead box O4
Sequence:
MFWSRMCSLGNPAKLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSDNFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGAAILRDLINEAMDVKLKRQEAQQRAVDQDDDENSEEDEMDSGTMVRAAGDDMGTVRVASTMSGGANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKNVSGSLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLSALDPMMEQEMEEIRQKYRSKRQPILDAIEAKKRRQQNF
Protein: P2Y purinoceptor 12 (P2Y12) (P2Y12 platelet ADP receptor) (Q9EPX4)
Organism: Rattus norvegicus (Rat)
Function: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11196645}; Multi-pass membrane protein {ECO:0000269|PubMed:11196645}.
Interaction partners:
- Guanine nucleotide-binding protein G
- P2Y purinoceptor 13
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transmembrane protein 119.
- P2X purinoceptor 1
- Triggering receptor expressed on myeloid cells 2
- Macrophage colony-stimulating factor 1 receptor
- P2X purinoceptor 4
- Macrosialin
Sequence:
MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
Protein: EGF-like domain-containing protein (O44191)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Meiotic spindle formation protein 2
- glutamine synthetase
- PUM-HD domain-containing protein
- Chitin-binding domain protein cbd-1
- RNA-binding protein pos-1
- Inactive protein-tyrosine phosphatase egg-5
- EF-hand domain-containing protein
- Chondroitin proteoglycan 4 domain-containing protein
- RING-type domain-containing protein
- Pumilio domain-containing protein 5
Sequence:
MRTMRLAWLLPLFIHILIKNTAQAPAVNNSTCDQAKEFDCGNGRLRCIPAEWQCDNVADCDNGRDESGCSYAHHCSTSFMLCKNGLCVANEFKCDGEDDCRDGSDEQHCEYNILKSRFDGSNPSAPTTFVGHNGPECHPPRLRCRSGQCIQPDLVCDGHTDCSGGDDEVNCTRRGHENMQSSTDFHDDVHLVDPTFFANEDNKCRSGYTMCHSGDVCIPDSFLCDGDLDCDDASDEKNCQTNAPSEEEYLSGQADHMHSCSAAGMYSCGTKGSEIGVCIPMNATCNGIKECPLGDDESKHCSECARKRCDHTCMNTPHGARCICQEGYKLADDGLTCEDEDECATHGHLCQHFCEDRLGSFACKCANGYELETDGHSCKYETTTTPEGYLFISLGGEVRQMPLADFTDGSNYSPIQKFAGHGTIRSIDFMHRNNKMFMSISDEHGDPTGELSVSDNGLMRVLRENVIGVSNVAVDWIGGNVFFTQKSPSPSAGISICTMSGMFCRRVIEGKEQGQSYRGLVVHPMRGLIIWIDSYQKYHRIMMANMDGSQVRILLDNKLEVPSALAIDYIRHDVYFGDVERQLIERVNIDTKERRVVISNGVHHPYDMAYFNGFLYWADWGSESLKVQEMTHHHSSPQVIHTFNRYPYGIAVNHSLYQTGPPSNPCLELECPWLCVIVPKSDFIMTAKCVCPDGYTHSVTENSCIPPVTIEDEENLEKLSHIGSALMAEYCEAGVACMNGGACRELQNEHGRAHRIVCDCEGPYDGQYCERLNPEKFSAMEEEDSSLWLIVLLLIFLIIVAVVGIIAFLWFSQQEHMKDVISTARVRVDNMARKAEDAAAPIVEKFRKVTDKQRSTPPREGCQTATNVDFVSYETNAEKRIRMDSSPTSYGNPMYDEVPESSTGFVRSASAPFAGVIRFENDSLL
Protein: PGM_PMM_I domain-containing protein (Q86DA0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTLGCAKLDKQVADWLAWDKNDKNRNEIQKLVDEKNVDALKARMDTRLVFGTAGVRSPMQAGFGRLNDLTIIQITHGFARHMLNVYGQPKNGVAIGFDGRYNSRRFAELSANVFVRNNIPVYLFSEVSPTPVVSWATIKLGCDAGLIITASHNPKEDNGYKAYWSNGAQIIGPHDTEIVRIKEAEPQPRDEYWDLSELKSSPLFHSADVVIDPYFEVEKSLNFTREINGSTPLKFTYSAFHGIGYHYTKRMFAEFGFPASSFISVAEQQDPNPDFPTIPFPNPEEGRKVLTLAMETADKNGSTVILANDPDADRIQMAEKQKELQKRDHPDRIQMDGKSSRGAPCRWKSGHSGVGRIDRIHARAYHGQGRRVRCRSFRRNRRFPSRGGKIVARPAVRSLQSIWLPFGQIHLLDGTGSGGHQEALQHIESRSEVPDENRRSRSGIRERLDDRIRQLKARQ
Protein: Doublesex- and mab-3-related transcription factor C2 (Q8IXT2)
Organism: Homo sapiens (Human)
Function: May be involved in sexual development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
Sequence:
MEPSDMPAGYHCPLDSAPWDETRDPQSTELIPRRAISRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNHFRKGTTQPQVPSGKENIAPQPQTPHGAVLLAPTPPGKNSCGPLLLSHPPEASPLSWTPVPPGPWVPGHWLPPGFSMPPPVVCRLLYQEPAVSLPPFPGFDPGTSLQLPTHGPFTTCPGSHPVLTAPLSGEPQGPPSQPRTHSTLILQPCGTPDPLQLQPQASGASCLARTSGPSEWQLQQEAAEALVGLKDSSQAPRVTPSVPPNPAWISLLHPCGPPAPAGGRGFQPVGPCLRPSPAPSVALHIGRLGSISLLS
Protein: T. brucei spp.-specific protein (Q57YS5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLILIFTFSLVSFFIPANNTLYVESAQAIDHECKARAAKHRESKGRKTHSDMPPHRKHPARGRSPRNKRYNGEGKPATKRGRSWSKQPSGPLTTNCDGEASSYTTAGTPPVASDHKFCEKTRSTKPSLEVTRTHIAPNTTTAAEVIPNASVTSAVGSAGGTETAATPTAKGADNLSDTDMEKYNDLQRLLRRIIALEFSERCTQRSITVVTMICETLCTDPVAIVKVMEVVDQCFGEAVRSQEPRLLMHYWYILDAILKHFNGKPHLLKAVLVAIPHFVRQYLPWRGSNLAGQPWSEYDKYRPAYEDMLGTWKVVLEERALEEIMKLWREGMGNHYADKVGNVGARVPLGNATADSQNSDAAH
Protein: Short-chain dehydrogenase, putative (Q389B9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Putative enoyl-CoA reductase
- very-long-chain
Sequence:
MFYIDDLFWTSLNYATSWVGLVSILTYLLVVLLQQLALHVPQNLKKKYAAEWALVTGASSGIGKAIAEKLAEQKINVVLVALDDPLLSSTFAELQQRYPKQSFRKVGVNLGEEGMRYMQPIVEATKDLHINLLFNNAGYINTGLFADTTIERLRANMECNAGCAVPITHHFLRQMLQRQQRGLVSFTSSASCYLPGPTATLYSPTKAFLTNFATTVAAEVRDAGVDVVVIHPSPVNTNFYKNQGPLLNSLKTAQSAAGSPMNIAEQIFAAAGRLTVWDQGVTCAAFRIVNKVIDFQLFSELVVRFAWLNGDHKRLVANSNTRGKKQS
Protein: Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) (Q8NCW6)
Organism: Homo sapiens (Human)
Function: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11925450}; Single-pass type II membrane protein {ECO:0000269|PubMed:11925450}.
Interaction partners:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
- C1GALT1-specific chaperone 1-like protein
Sequence:
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSSSQQWHLEG
Protein: Leu/Ile/Val-binding protein (LIV-BP) (P0AD96)
Organism: Escherichia coli (strain K12)
Function: This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.
Subcellular location: Periplasm.
Interaction partners:
- High-affinity branched-chain amino acid transport system permease protein LivM
- High-affinity branched-chain amino acid transport system permease protein LivH
- High-affinity branched-chain amino acid transport ATP-binding protein LivG
- High-affinity branched-chain amino acid transport ATP-binding protein LivF
- Leucine-specific-binding protein
- Dipeptide-binding protein
- Lysine/arginine/ornithine-binding periplasmic protein
- Glutamate/aspartate import solute-binding protein
- Histidine-binding periplasmic protein
- Inner membrane amino-acid ABC transporter permease protein YhdY
Sequence:
MNIKGKALLAGCIALAFSNMALAEDIKVAVVGAMSGPVAQYGDQEFTGAEQAVADINAKGGIKGNKLQIVKYDDACDPKQAVAVANKVVNDGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTARGYQLILRTTGLDSDQGPTAAKYILEKVKPQRIAIVHDKQQYGEGLARAVQDGLKKGNANVVFFDGITAGEKDFSTLVARLKKENIDFVYYGGYHPEMGQILRQARAAGLKTQFMGPEGVANVSLSNIAGESAEGLLVTKPKNYDQVPANKPIVDAIKAKKQDPSGAFVWTTYAALQSLQAGLNQSDDPAEIAKYLKANSVDTVMGPLTWDEKGDLKGFEFGVFDWHANGTATDAK
Protein: Coiled-coil domain-containing protein 88B (Gipie) (Hook-related protein 3) (HkRP3) (Q4QRL3)
Organism: Mus musculus (Mouse)
Function: Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei. Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (By similarity). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis.
Subcellular location: Membrane {ECO:0000269|PubMed:25403443}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:A6NC98}. Endoplasmic reticulum {ECO:0000250|UniProtKB:A6NC98}. Golgi apparatus {ECO:0000250|UniProtKB:A6NC98}. Cytoplasm {ECO:0000250|UniProtKB:A6NC98}.
Interaction partners:
Sequence:
MEGAKGPRLRGFLSGSLATWALGLAGLVGEAEESAGGTEEEEEEEEEEGALCTEKRFLRLIDGALLLRVLGIIAPSSRGGLRMVRGRDGPAACRMWNLCHLWGRLRDFYQEELQLLILSPPPDLQTMGCDPFSEEAVDELESILRLLLGASVQCEHRELFIRHIRGLSLDVQSELAGAIQEVTQPGAGVVLALAGPESGELVAEELEMQLRSLTGMMSRLARERDLGAQRLAELLLEREPAHLLLPEAPANASAEGVSHHLALQLTNAKAQLRRLRQEVEEKAEQLLDSQAEVQGLEAEIRRLRQETQALSAQAKRAELYREEAEALRERAGRLPRLQEELRRCREKLQAAEVFKGQLEEERVLSEALEASKVLLEEQLEVARERSARLHETQRENLLLRTRLGEAHADLDSLRHQLEQLVEENVELELELQRSLEPPPGSPGEASLPGAAPSLQDEVREAEAGRLRAVERENRELRGQLQMLQAQLGSQHPLLEEQRENSRQPPVPNRDPATPSALHHSPQSPACQIGGEGSESLDLPSPASYSDITRSPKCSQAPDSHPELESPLQMVSQDPQTSDQALQESDPTVETHQCLEKSGHRVPLQSPIVWDPPQGPEVRIEVQELLGETGSREAPQGELVHKAQVLKQESPKCRPRSAELTLREPLKDQKALDRELELSKQQKETGRHEQRPKGLESKLGPQKPQQTSEGVPDAWSREEPTPGETLVSAIPEEQALRDEVAQLRREVAGLEVKLQAQAQRLEARSAEALCLSEELAQARRTEAEAHQEAEAQAREQARLREAVDTASLELEAASREREALAEALAAAGRERRQWERDGPRLRAQVEAAEQQVQALESQVRCHLEEAEREHAEKQALREELEKAVLRGQELGDRLEHLQEELEQAALERQKFLQEQENQHQRYRHLEQRLEAELQAASTSKEEALMELKARALQLEEELIQLRQYPVDLATGARAGPRTVETQNGRLIEVERNNATLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSMMEMQGQELHRKLGVLEEEVRAARRAQEETRGQQQALLRDHEALVQLQRRQETELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRANVEAQEVALLAERERLMQDGHRQRGLEEELRRLQNEHERAQMLLAEVSRERGELQGERGELRSRLARLELERAQLEIQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPGPLPRTKKGSWLADKVKRLIRPRREGALHGGPRLGADGAGSTESLGGPLETELPEGREADGTGSSSPAPMRRVQSSLCLGDETLAGGQRRRLSSRFPGGRSSASFSPGDTPRQRFRQRRPGPLGAPSTHSKGSGVEWDGSIKTLSEHEADDTREAFQEQKPEKQFLTPSLSQ
Protein: SepB protein (C8VF02)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA replication licensing factor MCM4
- DNA replication initiation factor Cdc45
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM3
- DNA replication complex GINS protein psf2
- DNA replication licensing factor MCM2
- DNA polymerase
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM6
- DNA polymerase epsilon subunit B
Sequence:
MSDPVRPRGRPAHTPGTTVLTYTPDGRYIITGGSNSAIRIYTDGEDGEPKTVEEGADAHLAIGATNEYFFMGAEDGTVWQYEVKSGRMDKLLTRTALAVRDIAITKDNGWVAVASDELTVKLVNIEDMTKVKYMREQTKGTKHITFDPNGRYVAVSCTDGIVYLYSMDTEEPELARKLDGVIRRLEPEDEATARVVWHPDGTAFATADASRDIALFSVGEWKKEMSFSGGHNGDITAMSWSPNGALMVTAAKDGQVLLWESKTQKILHRYNFPNVINLAWHPTKNGVSLTTSDGEIFIFDGFVPKDYQALLQKPLQAAPIFPGALTEISDNVQRPLASRPKEALRRGSIDSLDDILGYDQDMEDFVEDDDGAGYVEDVNGFGKRTNKHLGDIEGHMDKRTLTSFPKPKIHPPLQPGSTPWRGNRRYLCLNLTGAVWTVDQETHNTVTVEFYDRELHRDFHFTDPFLYDRACLNENGALFSNNPVDDSPATIFYRPHETWTTRADWKTTLPKGEHIRALALSDSYIVAVTTKDYVRVYTLYGTPFRVYRQKSPAVTCAAWRDYVMTIGNGPLGSDGRTGTLRYSIENVKRDEICQNEDVVAIPEGAELKSVFFTDMGDPCIYDTEGVLLVLQHWRTQGQARWVPLLDTKQLERLASGRKEETYWPVAVAQDKFHCIILKGGDRYPYFPRPMLSEFDFQIPISDKPKPQEEDEEGSTARNDSMRLEESFVRGNLLLSLFQDLLSATHATATQRAELSRKELELDKVLLQLLAIECREGEERGMKALELVHMMKDRNGKMVEAAVKVAQRYNRGVLEDKIRDLAARRYAGEDDDDELAF
Protein: Protein cab-1 (Q93249)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein dct-6
Sequence:
MRYTFSDEKKATTTTTSRAKSQARLLNSASYRRAARTTLRHSYGMGMWRAVALLACLSATHAALFTEGGAVQNGKDNKANKYVEFAHDDKINKEDLLKYYGKEVEQYKDDDSYMEYLIEYMKSHPVPAQFPNFEQEAEQEHQDELNQWLEQLMNEQELLEPANAAVKDAEQKAPLAPVHHKQVAQKPAQEPFDLDDLLRGELMLENEIAKESELKKTQEKLSEQTPSAKANVESLESAMQTATGEPQVPQKKGQNEFVSFVEQEPQPAKQTISSQTVDKRRLATSAEYSGSAPRYSSSSLLLLAVGTVMCVGLIGTVAGGTYYYKNNRRTETPDDGEYAPYAGTGPGFRKNKGNKGDETLAYKAQLHQYQQAKQKIICGEDAPGIIESDGEDGADEENNYSVYECPGLAPTGDIEVCNPNFAAQP
Protein: Uncharacterized protein Rv0007 (P9WMA7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- DNA gyrase subunit A
- Conserved hypothetical membrane protein
- DNA gyrase subunit B
- Possible conserved membrane protein
- Conserved protein
- Probable conserved proline rich membrane protein
- Uncharacterized membrane protein Rv3835
- Possible conserved membrane protein
- Probable conserved transmembrane alanine rich protein
- Probable conserved transmembrane protein
Sequence:
MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPPPWQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRTPQPDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAGSSGGRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMITVAFLYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMTALATIGAFVYNLITDLIGGIEVTLADRD
Protein: Olfactory receptor (Q8VF14)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MEKITSAVDVHNIPLKNMTEATMFILLGFTDDFELQVFLFLLFLAIYLFTLVGNFGLVVLVIGDCRLHNPMYYFLSVLSFLDACYSTVVTPKMLVNFLSENKSISFLACATQMLLFVSLGTTECFLLAAMAYDRYVAIYNPLLYTVAMSPRVYLPLIIASYAGGVVHGAIHTVATFSLSFCGSNEIKHVFCDIPALLALSCSDTHTNELLVLYLVGLIEIVTILIVLVSYGFILFAILNMHSAEGRRKVFSTCGSHLTGVSIYHGTILFTYMRPSSSYASNHDMVVSIFYTIVIPMLNPIIYSLRNKDVKVAFNKLWRKCDS
Protein: Cryptochrome 3 (Cryptochrome circadian regulator 2) (Cryptochrome-2) (Q7ZU53)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Calcium and integrin-binding 1
- Period circadian protein homolog 2
- Aryl hydrocarbon receptor nuclear translocator-like 1a
- Period circadian clock 3.
- BHLH-PAS transcription factor
- Nuclear receptor subfamily 1 group D member 1
- Period circadian clock 1a.
- Protein timeless homolog
- Circadian locomoter output cycles protein kaput
- Aryl hydrocarbon receptor nuclear translocator-like 2
Sequence:
MVVNSVHWFRKGLRLHDNPALQEALNGADTVRCVYILDPWFAGSANVGVNRWRFLLESLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFKEWNVTRLTFEYDSEPYGKERDAAIIKMAQEYGVETVVRNTHTLYNPDRIIEMNNHSPPLTFKRFQAIVNRLELPRKPLPTITQEQMARCRTQISDNHDEHYGVPSLEELGFRTQGDSLHVWKGGETEALERLNKHLDRKAWVANFERPRISGQSLFPSPTGLSPYLRFGCLSCRVFYYNLRDLFMKLRRRSSPPLSLFGQLLWREFFYTAGTNNPNFDHMEGNPICVQIPWDHNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGMKVFEELLLDADWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYIPKLKDYPNRYIYEPWNAPESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQLSHYRGLSLLASVPTIQEEAEPPMSDDSQASSSSTGQASSPPHLSITAPSTPPLSESSSPNSSPTASTSVPHTQRKRVRPSETPSKQKTKVKHTSQARGLELKMDDKQ
Protein: Choline transporter-like protein ctl1 (O74441)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the normal organization of the preautophagosomal structure (PAS) and for the correct subcellular location of atg9.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Preautophagosomal structure membrane; Multi-pass membrane protein.
Interaction partners:
- SVP1-like protein 2
- Serine/threonine-protein kinase atg1
- Autophagy protein 13
- Autophagy-related protein 2
- Autophagy protein 16
- Autophagy-related protein 9
- Ubiquitin-like protein ATG12
- Autophagy-related protein 17
Sequence:
MFSDYASRFLAQSRFSSVDQRNFKYPTSRSNLQSVSIDRNSSIDSHETDLSAGSSSLHGLNSLIDSGSIHWQLREQEQSNSHISRNENELFSKENSIYNGNFSENLGVQPNPQTISHESVNEEYTELPYDAHLPSEQKVPDRKWGLTFGFLTLALFTYSFLMVWRTNPNIPPATSPYAAIQKAFPLFHKDAIICMMLSVIWLFCLVAIPRFLYFLLASVPLTMFAFAVYLLKASRIHLETSIQPKLMLLTGIILLVAPILLSYYVWRRRIHFETSFNIIRLACRVIADIPQITLIFISFLFSFYVLIFIWVRLFARLFLRGSTLVGSVWVLPRSSWVLASFYSLHFLWLCTFFHALQCAIISSIVSQWFFYRDTKSSATKTNLVSHFFYHVVSNQYGLCAFSSFLVVITKVPLHFLPTWLRHVSRIVYYMFSKTSASYVTSPLTLAYASIYSVPYMNASKALYQIEQLNRVGLRRRSYYFSKYTLLAARSLLAIGVGVTSWNYSIHENGVFYGYIVGLLGGFLAWLIIGAIEGGLSMIVDALLICSIIDISSCQGDPNGSHCFEAWQLFESNGY