wanglab/gogpt-training-data huggingface dataset:
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (Q8VYU3)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Interaction partners:
- Pterin-binding domain-containing protein
- Dihydroneopterin aldolase/epimerase domain-containing protein
- GTP cyclohydrolase II domain-containing protein
- GTP cyclohydrolase II
- GTP cyclohydrolase II
- Uncharacterized protein
- Aminodeoxychorismate synthase, chloroplastic
- DHFR domain-containing protein
- Molybdenum cofactor biosynthesis protein 1
- Vta1/callose synthase N-terminal domain-containing protein
Sequence:
MGALDEGHYHAEIDNEVSFELGFETQPETLVIQDAVRVLLQGLGEDINREGIKKTPFRVAKALRQGTRGYKQKVNDIVHGALFPEAGLEGGSGQAGGVGGLVIVRDLDLFSYCESCLLPFQVKCHVGYVPSGKRVVGLSKLSRVADIFAKRLQSPQRLADEVCTALQHGIKPTGVAVVLQCMHIHFPNFESAFLDSTSQGWVKITATSGSGVFEDGNADVWTDFWSLLKFRGISIDNAHRRSSGQSWCPSQSCGMPGQANSAMTNAVNSILKSLGEDPLREELVETPSRFVKWFMNFRNSNLEMKLNGFVRSRIDTRSPQGGNFNDGICSELNLSFWSQCEHHLLPFQGVVHIGYHSSDGVNPVGRPLVQSVVHFYGFKLQVQERVTRQIAETVSSFLGEDIIVVVEANHTCMISRGIEKFGSNTATFAVLGRFSTDPVARAKFLQSLPDSGSAGR
Protein: Cytochrome P450 CYP94D109 (PpCYP94D109) (EC 1.14.14.-) (A0A517FND0)
Organism: Paris polyphylla (Daiswa polyphylla)
Function: Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e.g. furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones. During the 5,6-spiroketalization of cholesterol, may catalyze the 27-monohydroxylation of furostanol-type steroid to an intermediate product that undergoes a stereospecific formation of the terminal heterocycle to yield diosgenin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MESLSLIFISFITLIVFLVVSASKKRSHPSGYEPDIPKGGCPMLDSTAYLVLSSPTNTAVTSTGIITSNPENIEHVLKTNFANYPKGEHLTYGLYDLLGRGIFNSDGDHWKLQRKIASLEFNTRTIRHFVTHDVSREVLDRLLPSLSRAANSGEIIDLQEVLDRLAFDNVCKIAFDDDPARLADKKFNDGENDYYGKFAKAFGEAAEISTQRFEKSRWKIARALNLGTERKMKNALAIVNEFAMQVVREMKRKRAEEGKGRGSSADLLSLFISEGEFSDEFLRDVVISFVLAGRDTTSSTMAFFFWQVSTRPSICQKIKEEIVSVRKNHNNSQGGAFTLEELREMDYLHAVLSETLRLYPIVPLHARYTLADDVLPDGTMVKKGSTVMHSIYAMGRMESIWGADCLEFRPERWLENGVFRPKSPFLFPVFLAGPRMCLGKETAYMQMKAVAASVMEKFKIEVADGKHESEREYYLEIVLRLKGGLPVRVTEKEWSDNSAVNV
Protein: U13-myrmicitoxin-Tb1a (U13-MYRTX-Tb1a) [Cleaved into: U13-myrmicitoxin-Tb1a (cleaved) (U13-MYRTX-Tb1a (cleaved))] (A0A6M3Z541)
Organism: Tetramorium bicarinatum (Tramp ant)
Subcellular location: Secreted {ECO:0000269|PubMed:30149710}.
Interaction partners:
Sequence:
MKLIYIFSLVAVIAVTMIPGIMGEAEAEGRPPQIGIFDQIDKGMAAFMDLFKG
Protein: RRM domain-containing protein (Q3THB3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAAGVEAAAEVAATEPKMEEESGAPCVPSGNGAPGPKGEERPTQNEKRKEKNIKRGGNRFEPYSNPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGIVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLSKGIGMGNLGPAGMGMEGIGFGINKIGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGAGGSVPGIERMGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSSIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMDRMVPTGMGASLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Protein: Gamma carbonic anhydrase-like 1, mitochondrial (AtCAL1) (GAMMA CAL1) (Q9FMV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in complex I assembly in mitochondria and respiration.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15821992}; Peripheral membrane protein {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15821992}; Matrix side {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15821992}. Note=Probably integral to the membrane. {ECO:0000250}.
Interaction partners:
- Gamma carbonic anhydrase 1, mitochondrial
- NADH-ubiquinone oxidoreductase chain 2
- NADH-ubiquinone oxidoreductase chain 6
- Excitatory amino acid transporter
- L-galactono-1,4-lactone dehydrogenase, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- Cytochrome c1 1, heme protein, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Cytochrome b-c1 complex subunit 7-1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
Sequence:
MATSIARLSRRGVTSNLIRRCFAAEAALARKTELPKPQFTVSPSTDRVKWDYRGQRQIIPLGQWLPKVAVDAYVAPNVVLAGQVTVWDGSSVWNGAVLRGDLNKITVGFCSNVQERCVVHAAWSSPTGLPAATIIDRYVTVGAYSLLRSCTIEPECIIGQHSILMEGSLVETRSILEAGSVVPPGRRIPSGELWGGNPARFIRTLTNEETLEIPKLAVAINHLSGDYFSEFLPYSTVYLEVEKFKKSLGIAV
Protein: Uncharacterized protein (A0A2H3HA93)
Organism: Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum)
Interaction partners:
Sequence:
MSSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTREVLVDDRQVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNAKSFEALDSWRDEFLIQASPRDPPNFPFVVLGNKIDVEESKRVISNKRAMTFCQSKGDIPYFETSAKEAINIDQAFEVIARNALAQEESEEFSGDFDDPINIHIENDRDGCAC
Protein: Uncharacterized protein LOC100137125 precursor (Zgc:175135) (F1QP18)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPWPKGILLFVMAVMSFSSSIAGPKAFSDSSANGAVSGDAIHIGRLSIGGQSVEPDNKKDKSRPASAEQTIEDERFRLARAKLQRLGPSLQCGNDSMTLNIKGHRTPHFLVERGEGSPVSLSEMPASCGFSLKRARRDVSLVAPYTGCNVRQQGGSYVLPLIIMGAPVQMSCPVSPRLPVVSCTSSGMIVSFGVREDDVLVKVSGSWMPLSLTSSMCSFTLDNFGGSMVLTAPFTGSCWDSQDTDWNLTLLLGDREVVLSCPKATDTPTVPPTPFPQGYPYFPFGYPWWYPWNQAPPAAPPTTPAPVKAPVYNPFPMYYPYYYGGFPHRRHHHRHHHRHWYPESQESWFPMLPPYEFAQFQPPPTPAAPQVQQYPVFPMPFNPVNTGFKNPFWPPVPQSVSNPQSLNSPWNIWARKQKR
Protein: Probable inactive receptor kinase At5g53320 (Q9FK10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKCQVVLILIVVIFNVCIEAETIKEDKHTLLQFVNNINHSHSLNWSPSLSICTKWTGVTCNSDHSSVDALHLAATGLRGDIELSIIARLSNLRFLILSSNNISGTFPTTLQALKNLTELKLDFNEFSGPLPSDLSSWERLQVLDLSNNRFNGSIPSSIGKLTLLHSLNLAYNKFSGEIPDLHIPGLKLLNLAHNNLTGTVPQSLQRFPLSAFVGNKVLAPVHSSLRKHTKHHNHVVLGIALSVCFAILALLAILLVIIIHNREEQRRSSKDKPSKRRKDSDPNVGEGDNKIVFFEGKNLVFDLEDLLRASAEVLGKGPFGTTYKVDLEDSATIVVKRIKEVSVPQREFEQQIENIGSIKHENVATLRGYFYSKDEKLVVYDYYEHGSLSTLLHGQKGLRDRKRLEWETRLNMVYGTARGVAHIHSQSGGKLVHGNIKSSNIFLNGKGYGCISGTGMATLMHSLPRHAVGYRAPEITDTRKGTQPSDVYSFGILIFEVLTGKSEVANLVRWVNSVVREEWTGEVFDEELLRCTQVEEEMVEMLQVGMVCTARLPEKRPNMIEVVRMVEEIRPEKLASGYRSEVSTGATTTPIGSLSGSPYIL
Protein: Cysteine/Histidine-rich C1 domain family protein (Q9ZPU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLDSHNRGLICKLPVVPLFWCNNKEPNGADFCCSACKLTNLGTAYYFCATCRKKFHKECVESPLEIKHPSYPFQSLQLYSSPFALVNCICCDISFQDIIYHSSNHKLSMHPVCAMKPVPIFIDHTKRHPHPLTFSPREAFLPCNVCGLIKESILTYVCVPCDFVVHQDCLYFTHVIKISRHHHRIIFTSSLPYGKWSCGVCRREVDNHYGAYSCIKCGDYFVHTRCALRKDVWNGEDLEGVPEEPEIDVEPYETIADGIILHFSHDHHLKLEINRVYDENKFCQACILPIYEGTYYSCLDKCEFILHEACVNAPRKKHHPLHTHPLTLKVVSIGYDHYRRRGNYFDCGACKRASCGFVYDSQDFSLDLRCASISEPFQYQGHKHPLFLALEPDEEKAAICQICQEDGDGNNYIRKLNCMECKYIICFRCATLPYKAKYKHDKHFLTFREGEEGSDQLDWCEVCEKKLIYSRKGGFYACDDCCTTLHVDCLLGEMSLFDGLNVIIAGASSFTSRSLLF
Protein: Uncharacterized protein (Q388A1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVVIHSGLVTPVLEIMSLVKPLPFDVDVLLDEHPDMTVYHRPPLQSRGSGSKYICNHHPVELLSYEVYLCDTEDEPVVDFEVSNRIVVRYQLNPYCAAQLSHLRGFEPLVYPYESRYLRPAYVEVAHGSGGCCFNGSGSSYGINVCVAPTDIFAGFPRSNNGDDAVIYSTVPHIRKLLQRPFSPFMECGPLIADDVFVRWGSSGLLSLTDTCDLGMFTIEGVCGVSSHVM
Protein: Tripeptidyl peptidase 2 (A0A494C0A3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTKLDSSDIYNELKETYPNYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHTQAQDGAISTDAEGKEEEGESPLDSLAETFWETTKWTDLFDNKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
Protein: Seven TM Receptor (Seven transmembrane receptor 2) (G5EF54)
Organism: Caenorhabditis elegans
Interaction partners:
- G-protein coupled receptors family 1 profile domain-containing protein
- Innexin-19
- Clc-like protein
- Homeobox protein ceh-36
- Guanine nucleotide-binding protein alpha-17 subunit
- Serpentine receptor class delta-1
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Mitogen-activated protein kinase kinase kinase nsy-1
Sequence:
MPTVQWIQLEETSKITGGSISVITNGLLMYLILTKSPSKLGSYKWLMLYTSFFEFFYAFVNLFAGPFVHTYGSAFIVFQDMNTFYFSHHVAQFLVCLYCSCFGFSMAIFGGHFIYRYGAIDSQFYQKYLSGFKQSLLYILPFCYGILWGVICWIYYGETPDRTNYLRETLLSNYRLKIEECAYISARFWVSDKNNYLFPDFDSFFGIGVMWIILGSSMISVIYFGTRCYRWLTKKLEMIENISDSIKSLQRQLFNALLIQSAIPLFLMYMPAAMVFVFPMLNTELNLKYPFIGITIAIYPAIDPFPTIIIIKSYRRGFYELLRCLTGRQKNKVAVNPNVPSHAYTLPMSASNSIYVTN
Protein: LP19328p (Scarecrow, isoform B) (Q5BI77)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSHGLAYTTRIERKSYRELQINRDQYFVTAPNEEDLVMSLSPKDTLIHTAISQHHQVDTSTKLNTNETSTQNTVSTAAAAAVAHHHHNLSSIHHLQNLHSQHQSTLFNSNHSTPFSVTDILSPIEESYRKLELNGNPPSPFRSNSSSSSINSPGTLTTSTMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTANDPRFAISRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQFPLAQRRKRRVLFTQAQVGTYILSLLLKKKTQIFTEWKEVNLLQAK
Protein: Kynurenine 3-monooxygenase (EC 1.14.13.9) (Biosynthesis of nicotinic acid protein 4) (Kynurenine 3-hydroxylase) (Q5A7M3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018}.
Interaction partners:
- Kynureninase
- Kynurenine formamidase
- Aminotransferase class I/classII large domain-containing protein
- Kynurenine--oxoglutarate transaminase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Indoleamine 2,3-dioxygenase
- Nicotinate phosphoribosyltransferase
Sequence:
MSEEESQKTIGIVGAGLVGCLAALAFAKKGYDVTLFEYRPDPRTVDSSKRNLRSINLAVSSRGIRALQYVDPAMADRILEHVIPMKGRMIHDITGTKQESQVYGLNGESINSIDRSFLNNCLLDELDKSNVKILFKHKLVKLDTSNACRMTFIDGHNDAKTSTFDFVVGCDGAHSQFRYHLQKTMRMDYSQKYIDMQYLELYIPPSEDANNKFSIDANHLHIWPRHNFMLIALANKDGSFTSTFFSPWSVIEGISSSQEFVEFFRHNFPDAVGLIGEDALSSAFKSNPRGSLMQVSCYPYSNGKGIILGDAAHSMVPFYGQGMNCGFEDVRILMELIDTNNGDIEEAFKQYSAARKNDLDAICKLALDNYYEMSSKVVDIGYLIKKKLDYTLGKIFKNKWLPLYTMISFRDDIPYAKAIEIEKRQNRIMNNVGLGVLGTAAVYGLVKLGQYWNRRQ
Protein: TNF receptor superfamily member 9 (Tumor necrosis factor receptor superfamily member 9 isoform X1) (F1RII3)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MQDFIMGNGYYNIVATVLLVMNFERTRSVPDPCSNCSAGTFCGKNIQELCMPCPSNSFSSTSGQKACNVCRKCEGVFRTKKECSSTSNAVCECVPGFRCLGAGCAMCEEYCQQGQELTQEGCKDCSFGTFNDEEHGVCRPWTDCSLAGKPVLMNGTKARDVVCGPRPTDFSPGHTSHVIIFFLALMSTAVFVLVSYLALRFSVVQQGRKKLLYIVKQPFLKPAQTVQEEDACSCRFPEEEEGECEL
Protein: Zinc finger protein ztf-6 (Zinc finger putative transcription factor 6) (G5EC77)
Organism: Caenorhabditis elegans
Function: Probable transcription factor, involved in regulation of dopamine neuron lineage specification. May play a role in maintaining robustness of the Wnt/beta-catenin asymmetry pathway.
Interaction partners:
Sequence:
MGPDTTSERVSEDLMQAVTCLKRVMVGMKSNGTDYVQEQTPSNSTTVICTLVKITGALERCIESNKAMNDVLNGKMKCTTCGATSVGLLSDCHDSATSTTTTVSHRSSEEPPRRKPSAAGGDHDDEELECSSIESRSIRSVSSSVHTSAEDDETNQTMMVPTDVADVINAIVAGTNGSSNSNTTSSSKSPQEEEEEHDLVMKSILSTTTSTSNTKLELSEKLENPLQDTALLDQFLQASLLGQTPTVTPASEENEEDKEQNAVLTSFLQILFANQQAGNAILDAGSSENDGSTSSSQPSPPADPTASLDSLAMFESLLAESMNGNVLDANTSSADQKAAARKRKSTPMKVPKSENGAGYICPMDGCNKVFKEKGSVHRHFVTHIGMRFNCDKCKASYTQKHALMLHQKIHANPDAYQCRGCGTNYTTQNGLRLHRQRNPACMEVSNALEFNTSLNTSISEALSGPLSKNSSPTKQMVSAP
Protein: F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Q8N461)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE
Protein: AFG1-like ATPase (EC 3.6.-.-) (Lactation elevated protein 1) (Q3V384)
Organism: Mus musculus (Mouse)
Function: Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
Subcellular location: Mitochondrion membrane {ECO:0000250|UniProtKB:Q8WV93}.
Interaction partners:
Sequence:
MAASWSPLVTLRSAARSRLTGRGVGCGARVVAIPPPAPGPGKPLWKAYTVQTSEGVRPTAASEARLKALAVCHGPLDHYDFLIKSQELREDEHQRRVVQCLQKLQEDLKGYSIEEGGLFSKLFSRNKPPKGLYVYGDVGTGKTMVMDMFYAYVETKRKKRVHFHGFMLDVHRRIHHLKQSLPKRKAGFMAKSYDPIAPIAEEISQETSLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCDTLQLDSGVDYRKRELAPAGKLYYLTSEADVEAVVDKLFDELAQKQNDLTSPRILKVQGRELRLNKACGSVADCTFEELCERPLGASDYLELSKNFDTVIIRNIPQFSLAKRTQARRFITLIDNFYDFKVRIICSASAPISSLFLHQHQDSESDQSRILMDDLGLSQDSAGLSMFTGEEEIFAFQRTISRLTEMQTEQYWIEGDRSRK
Protein: Vitelline membrane protein Vm26Aa (Protein SV17.5) (Protein TU-2) (P11449)
Organism: Drosophila melanogaster (Fruit fly)
Function: Major early eggshell protein.
Subcellular location: Secreted {ECO:0000269|PubMed:18514182}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18514182}. Note=Secreted into the perivitelline space by follicle cells and becomes incorporated into the vitelline membrane. {ECO:0000305|PubMed:18514182}.
Interaction partners:
- Vitelline membrane protein Vm34Ca
- Vitelline membrane protein Vm26Ab
- Defective chorion protein, FC177 isoform
- Chorion protein S36
- Chorion protein S16
- Vitelline membrane protein Vm32E
- Chorion protein S38
- Chorion protein S19
- Chorion protein c at 7F
- Protein palisade
Sequence:
MKSFVCIALVAFAAAALASPTNVASATGSTGSSVTTQDGELEGVTGQGFGDLTRLRKSAYGGSSGGYGGSSIPAPPCPKNYLFSCQPNLAPVPCSAPAPSYGSAGAYSSPVATYVAPNYGVPQHQQQLYSAYVPQTYGYQY
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (PFTase/PGGTase I alpha) (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) (P29703)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. If X is Ser, Ala, Met, Cys, or Gln, then the protein is farnesylated, if X is Leu or Phe, then the protein is geranylgeranylated. The alpha subunit wraps partly around the beta subunit forming part of the active site. The beta subunit is responsible for isoprenoid and peptide-binding.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Protein farnesyltransferase subunit beta
- Geranylgeranyl transferase type-1 subunit beta
- CAAX prenyl protease 2
- CAAX prenyl protease 1
- Farnesyl pyrophosphate synthase
- Protein-S-isoprenylcysteine O-methyltransferase
- Geranylgeranyl pyrophosphate synthase BTS1
- Hexaprenyl pyrophosphate synthase, mitochondrial
- Dehydrodolichyl diphosphate synthase complex subunit RER2
- Dehydrodolichyl diphosphate synthase complex subunit SRT1-farnesyl diphosphate specific))
Sequence:
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN
Protein: Phospholipid scramblase family protein C343.06c (Q9UT84)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MLEILWANITPIQTFVSSNHLTMLYGLKRFGCRLYHHSKSTRYIDATAKVVSQEPAAISSTGAIPLNSPAAPLLSQDVLIVERQLEMMNVFLGYEQANRYVILNQQGQHLGYIAEQGASSILSSLSRQFFHTHRAFKADVMDSNGQLVLQLNRPFSWINSRLQIHSIDYSKFSSTLVGEVLQKWHLWRRRYELFLAKRSMFEQFAKIDERVLSWEFLLRNEQDRILGSVSRNFMGLPREFFTDTGNYVLRFTSTSAANGSVNENQLLQAAHGIANDVCARDMSLEERAVMLGSAVTIDFDYFSRIHGGPALGLNIPFMFGGSSSNHDYPAEDLSAQEILKNDQETTPSTNDSSSETKSPFLSDADLDQQDFWDIFDRDGDD
Protein: Uncharacterized protein (Q385I8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPLFSYECHCGYLVLVECDGCPEGAAQNLSAELRRLPSDAVGLCSGLPPLLVTNKYFTAMVQTVIICAHDFSFGTELNVSSVGFVFLVGDATSADSVPWHSAPMSCLIRVVMCYGSCGATRDLMHDACVLNNFELITHGEAYEMLSPGVETRGLLGGDLVGAARLIQILHNTVWPENTRVPHDDAKTISGTVSKNLVVFVGADSEEVMNCIAATVGNEVVNYTEHFRFTGFWPPKTVVSGSERDQRGLKRTETLEAPHKSFREGLCGTTLTVANEHYVSSLGVEFVHPVMFFPAMADLFMVKYGGRHAQLAVVCWPPLQHFQKVGAANGGNAPVRRLSLPVFIEQIKRWGVERCVVAATMDTDEEDTISPFEAHFCAEGGIEIVHGVFKAADKKHTHDINITAVGMARLLEMLHEAKWPERQRLIKLSESLSSDSQVNRVLFWSKATTTVEEETILFQVLRDMEVITPRTAGEQWKVVLPPTLASAVRKGPLAVTTARNRYFEAAISVHCYGGARALTKRDSPSSAEELSPFGVVIILTTTQSCKRESRNGLLTILSNCRASARGGHCRGDLVLNGPHGCESEMTQSLCAATEVEQAFVLYIVDGDENNDALVDDIEDIIKELMSDSEVSKCTHPSGGGAEEDWAKGSNGDGSSEDLPLRTDDDGCEGSFDDLMSVVPQIEVVYGAGPEDGIARLREIMNQHMWSNRVMVDKCIRSHNGSTSSSRNASFSTIKAEKVNDPSVPHNVNISEAEEVDVVRVGCELPPNYLIDPLTRKSVWVEALNGTALEGEQQQQQLMYWIDTMKQHGHRLSRTTRQRQAEILSKKLGEELGVS
Protein: Ankyrin repeat, PH and SEC7 domain containing protein secG (Q54KA7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Arf guanyl-nucleotide exchange factor
- Arf guanyl-nucleotide exchange factor
- ADP-ribosylation factor-related
Sequence:
MGSTSNSTKNTGSTTTTTTTAAPATTAKHSNSAPTRPSVHYYSSTGDIEKLSNLLNNSATSPDTPDSEKRTPLHHAAFCGSAACVNFLLDKKANANIKDSAGNTPLQWASSRGHLECIKLLVEKGGVDVNTKDDKNGTPLHKASLFASAECVLYLLNGKADPRAVTTNGETPLHHASAGGNPQCVELLIKADSKVNAVDNDCITPLHQASFSGHSSCVSLLLKKGAKVDPRDIHGISPLHNAASAGYVDCVEQLVRNGENINCVDIEGVTPLHHTCFNGNLQLTKRLIELGAKINMVDEMGETPLHKAAFNGHKEVCEYLLYLDPTMIDCRDSRQSTSLHLAAFNGLLDMVDLLIRYKAQINIKDEEGATPLHKASFNGHSSCAKLLVDKGAPICIVDSQGATPLHKAAFNGRSKCLATLIRSGAELEVKDSQGGTPLHNAAYNGHSDCCRILLKKGANVNAVDTHSSTPLHLASAAGARDTVDVLIQFKARIDAKNFAGKTPLVYAIKKNHSDVARVLIRAGADLDQVSLRSSVDFTKTFGTENHDEIYQIVNKRESSNHEVDELQLALEQQAKEDMEQLAAEKQKLLLIKAAIAQFNSHPKKGIEFIVANGVISEKNPKEVAHFLLTHSELSKQSIGEYIGEGDDFNLQVLHAFVDELNFFGLDFDVALRKYLLTFRLPGEAQKIDRMMEKFASQFYQHNPENKVFVNQDAVYVLAFSVIMLNTDAHNPNIKKKMTKAEFLRNNSGINSGDDLPPDFMENLYDKIVTNEIKMERDGNQANQHVEKKGWLTKQGGRIKTWKKRWFILTANCLLYYKTPQDHEPCGIIPLENVVVTIDPQKKFCFMLHSSQEQMKACKLNSDGTLVQANHAAYFIAAANMAEMDSWVQSIKSNIHSNPNFEQLLKRKAETIRGRGKVSTKPIQNRKQTISGPPPSTTTTTTSTASNNVTSVGSPPNSGSVLNSSGSKPVTFSSTSSPVQQQTSALS
Protein: Preprofallaxidin-8 [Cleaved into: Fallaxidin-2.1; Fallaxidin-3.2; Fallaxidin-5.2] (B5LUR0)
Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)
Function: Fallaxidin-2.1 shows no antibacterial activity against Gram-positive or Gram-negative bacteria. Does not inhibit the formation of NO by neuronal nitric oxide synthase. Has no effect on splenocyte proliferation or smooth muscle contraction.
Subcellular location: Secreted {ECO:0000269|PubMed:18803332}.
Interaction partners:
Sequence:
MASLKKSLFLVLFLGLLSLSICEEQKRENEEDAEDENHEEESEEKRGLLDFAKHVIGIASKLGKRSEEKRFWPFMGKRSEEKRFWPFMGKRSEEKRFFRVLAKLGKLAK
Protein: Histone H4-like protein type G (H4-clustered histone 7) (Q99525)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H3.3C
- Histone H2A type 2-A
- Histone H3.1
- Histone H3.2
- Histone H3.1t
- Histone H3.3
- Histone H2A type 2-C
- Histone H2B type 2-E
- Histone H3-7
- Bromodomain-containing protein 4
Sequence:
MSVRGKAGKGLGKGGAKCHRKVLSDNIQGITKCTIRRLARHGGVKRILGLIYEETRRVFKVFLENVIWYAVTNTEHAKRKTVTAMAVVYVLKRQGRTL
Protein: Protein COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB4, chloroplastic (Q6NQK9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the biogenesis and accumulation of native cytochrome b6 in the thylakoid membrane. Controls the conversion of apocytochrome b6 to holocytochrome b6. Required for covalent binding of the c-type heme to cytochrome b6.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000305|PubMed:18593701}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB1
- Protein COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB3, chloroplastic
- Cytochrome c biogenesis protein CCS1, chloroplastic
- Rab escort protein 1
- AT3g17930/MEB5_15
- Pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial
- Zinc finger protein JAGGED-like
- Putative oxygen-evolving enhancer protein 2-2
- Cytochrome b6
Sequence:
MEARIILLRIQIPWSANRQFSHPPLDFPRFIRASSSSTSQKPKTYEGPKPRKNLVADFISKNDDLVRSLPIYVGGASLLAVLFNRTVSGIAPVADASSSQSRADLLALGLAVTNLLTGLVWLSIRPKSITPVNPKGVECKVVESDLPASMVSELLWAWESLKVATCCKSLVIVYNGICLIQIGMVAESPEDKKTVIVKTDKLMQGSVYRGVMKSKAQSYLANLSLYPGRSELPFLPANTQAVILQPLGDKGIAVIGGNTIRGFTSSDQAWISSIGEKLDATLGRYFVDSDEISRVTV
Protein: Verprolin 1, isoform I (Verprolin 1, isoform J) (E1JGR7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAIPPPPGPPPPPGPPPPPAMGGLKLGGAGGADARSALLSSIQKGTKLKKTTTVDKSGPALSGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLKPVNGIRATPSAGSAATTTSKSTTNSSAQQRSNSPPAATSASNASNGPMDFNTELTKHLTLKRQKQQQQQQPQPPTNNTHINATEANLRTNRGPPPQPPKSANSNDSILERMNIPRTAPTPPFGNSSSVKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLTSSTGSVRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLPMKPAISFGKPNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPLQFHGSESSSPNTSAGSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAISSQAPSPPITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASASPKSLLRDNVKPIILNGGPLNPPAPPPHRSCPPPPPPQRQSSNGGSGSGSAPVPPQRHSSIRPNAPSTPPTHMANASHQFGSSSGLSSGSGAGAAASVGRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKATNAPGNSSVNNNNNAVASNNNTTSNPNPGGFGGGLAPVLKPAHAPLKKHRAPAPPPQAGVAAATVSVIRQSSFLYGGAAGGSSGSTSIRPQSQPPGIGPRNSTVY
Protein: Uncharacterized protein Rv2269c (P9WLF9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3
- Beta-dihydromenaquinone-9 omega-hydroxylase
Sequence:
MANDARPLARLANCRVGDQSSATHAYTVGPVLGVPPTGGVDLRYGGRAGIGRSETVTDHGAVGRRYHQPCAGQIRLSELRVTILLRCETLCETAQLLRCPPLPCDCSTPL
Protein: Fructose-bisphosphate aldolase (EC 4.1.2.13) (B9PW35)
Organism: Toxoplasma gondii (strain ATCC 50861 / VEG)
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Glucose-6-phosphate isomerase
- phosphopyruvate hydratase
- Probable ATP-dependent 6-phosphofructokinase
- Phosphotransferase
- Glyceraldehyde-3-phosphate dehydrogenase
- Pyruvate kinase
- Phosphoglycerate mutase
- Triosephosphate isomerase
Sequence:
MLCIVERIAMPTRGVNPSAANGKLPPRTRSATGCRVYIHPMVKFISLLFAVFYARFFLLFCVRIQSTFPTMSGYGLPISQEVAKELAENARKIAAPGKGILAADESTGTIKKRFDSIGVENTEANRAFYRDLLFSTKGLGQYISGAILFEETLYQKSPSGVPMVDLLKAEGIIPGIKVDKGLETLPLTDDEKATMGLDGLSERCKKYYEAGARFAKWRAVLSIDPAKGKPTNLSITEVAHGLARYAAICQANRLVPIVEPEILTDGSHDITVCAEVTERVLAAVFKALNDHHVLLEGALLKPNMVTHGSDCPKPASHEEIAFYTVRSLKRTVPPALPGVMFLSGGQSEEDASLNLNEMNKMGPHPFQLSFSYGRALQASCLKAWKGVPENKAKAQQVLMERARANGEAQLGKYGGGAGGAAAASSLFEKRYVY