wanglab/gogpt-training-data huggingface dataset:
Protein: SH3 domain-binding protein 1 (Q9Y3L3)
Organism: Homo sapiens (Human)
Function: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells.
Subcellular location: Cell projection {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563}. Cell junction, tight junction {ECO:0000269|PubMed:22891260}. Cell junction, adherens junction {ECO:0000269|PubMed:22891260}. Cell projection, phagocytic cup {ECO:0000269|PubMed:26465210}. Nucleus {ECO:0000269|PubMed:22891260}. Cytoplasm, cytosol {ECO:0000269|PubMed:22891260}. Note=Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
Interaction partners:
- Rho GTPase-activating protein 17
- SH3 domain-containing kinase-binding protein 1
- Rho GTPase-activating protein 44
Sequence:
MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNPAQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN
Protein: Photosystem I reaction center subunit VIII (PSI-I) (P0C372)
Organism: Oryza sativa subsp. indica (Rice)
Function: May help in the organization of the PsaL subunit.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Photosystem I reaction center subunit IX
- Photosystem I iron-sulfur center
- Photosystem I P700 chlorophyll a apoprotein A1
- Photosystem I P700 chlorophyll a apoprotein A2
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Chlorophyll a-b binding protein
- Photosystem I reaction center subunit VI, chloroplastic
- Uncharacterized protein
- Chlorophyll a-b binding protein
Sequence:
MMDFNLPSIFVPLVGLVFPAIAMASLFLYVQKNKIV
Protein: Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (P54920)
Organism: Homo sapiens (Human)
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000305|PubMed:15029241}.
Interaction partners:
- Vesicle-fusing ATPase
- Gamma-soluble NSF attachment protein
- Vesicle-associated membrane protein 2
- Synaptosomal-associated protein 25
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Syntaxin-1A
- Syntaxin-6
- Syntaxin-7
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Synaptosomal-associated protein 23
Sequence:
MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR
Protein: Paired box protein 3 homolog (G5ED66)
Organism: Caenorhabditis elegans
Function: Transcriptional activator (By similarity). Regulates the lateral/ventral epidermal cell fate decision.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00381, ECO:0000269|PubMed:26953187}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim-22
- Mitochondrial import inner membrane translocase subunit Tim9
- Transcription factor sox-2
- Protein phosphatase eya-1
- C2H2-type domain-containing protein
- Mitochondrial import inner membrane translocase subunit Tim10
- Nuclear hormone receptor family member nhr-57
- Zinc finger protein tlp-1
Sequence:
MTTDSITFNHILGQGRVNQLGGVFINGRPLPIHVRHAIISMAKKGIKPCHISRQLKVSHGAVSKILNRYAETGSISPGQIGGSPRARLTVQAVEKEILIACDENPQMSAAELRDWLIHKDICTKGNAPTVPAIKRLIGNKGVGVPKKMERKRLSYSIDSILGISIDECSKSSSDDEEGSSPSNDASSRRNRTSFTAEQLDVLENAFRADTYPHANARESISKETGLSEEKIMTWFSNRRARCRKNMPMYQQYNVQGFGSSPPSYPTLLPSPMMFLPSYSTSPQLNPLFFQHILQSSPPSSQSSPPSSS
Protein: DEAD/H-box helicase 11 (F5GXJ8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSP
Protein: Uncharacterized protein (Q584U8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 30S ribosomal protein S8, putative
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
Sequence:
MFRSTRPRSVGYTPVNPDTSPMVAYSQYHWHYNLPQGMERPHSVNRTFAAPFQSNHSLVNKYRGVWIEFDMHPAFSVALEPQLRKLPRGRTLPKTPAEEVIADYTALAPLVDDEKTRDLWLAKVFQHCAFQRCGGAMELWERYCHQRFTAEGATAKPPLSLVKSVLFYCNKTDNSGWRALFDRCLKDGWNYTPLFDTAQWSFMLKSIGRMGDEDGVRAVLEEMLDVQADLDRVEARSVVIALNAVTNADVYEFVKKYLFNFGERKVKFLRTTYSDLRGHGAGKLRIPLKENDNMYYHVCWHSSIRSPRQFSPRQLYFDYTPSTLGSSSHNPNAKIDDIVKDKIEKWKAEGLLPEDYVHEDRVYDRSAAFKNVARQEKWKKMPKILKSKRMGYTGDP
Protein: Cyclin-Y-like protein 1 (Q8N7R7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:22184064}.
Interaction partners:
- Cyclin-dependent kinase 16
- Cyclin-Y
Sequence:
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTVKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKDLCRAAMRRSFSADNFIGIQRSKAILS
Protein: F protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted protein) (p16) (p17) (P0C045)
Organism: Hepatitis C virus genotype 1a (isolate H77) (HCV)
Function: Contributes to the RIGI-mediated inhibition of type I interferon production.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:12810869}. Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:12810869}.
Interaction partners:
Sequence:
MSTNPKPQRKKPNVTPTVAHRTSSSRVAVRSLVEFTCCRAGALDWVCARRGRLPSGRNLEVDVSLSPRHVGPRAGPGLSPGTLGPSMAMRVAGGRDGSCLPVALGLAGAPQTPGVGRAIWVRSSIPLRAASPTSWGTYRSSAPLLEALPGPWRMASGFWKTA
Protein: 26S proteasome regulatory subunit rpn10 (O94444)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10809753}.
Interaction partners:
- Probable 26S proteasome regulatory subunit rpn9
- 26S proteasome regulatory subunit rpn2
- 26S proteasome regulatory subunit rpn1
- Probable 26S proteasome regulatory subunit rpn3
- Probable 26S proteasome regulatory subunit rpn6
- 26S proteasome regulatory subunit rpn12
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit rpn7
- Probable proteasome subunit alpha type-3
- 26S proteasome regulatory subunit rpn502
Sequence:
MVLEATMILIDNSEWMINGDYIPTRFEAQKDTVHMIFNQKINDNPENMCGLMTIGDNSPQVLSTLTRDYGKFLSAMHDLPVRGNAKFGDGIQIAQLALKHRENKIQRQRIVAFVGSPIVEDEKNLIRLAKRMKKNNVAIDIIHIGELQNESALQHFIDAANSSDSCHLVSIPPSPQLLSDLVNQSPIGQGVVASQNQFEYGVDPNLDVELALALELSMAEERARQEVAAQKSSEETEDKKMQE
Protein: Nonaprenyl diphosphate synthase (EC 2.5.1.85) ((2E,6E)-farnesyl diphosphate synthase) (E,E-FPP synthase) (FPP synthase) (EC 2.5.1.10) (Geranylgeranyl diphosphate synthase) (GGPP synthase) (GGPS) (EC 2.5.1.29) (O06428)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP), with E,E-FPP to yield geranylgeranyl diphosphate (GGPP) and with GGPP to yield nonaprenyl diphosphate. May also have weak activity with dimethylallyl diphosphate (DMAPP).
Interaction partners:
- 
- 
- Geranylgeranyl diphosphate synthase
- Decaprenyl diphosphate synthase
- Dimethylallyltranstransferase
- 
- Phytoene synthase
- Isopentenyl-diphosphate Delta-isomerase
- Menaquinone reductase
- Type B diterpene cyclase
Sequence:
MRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVMSDSLLHLFNAGGKRFRPLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVMDEAQVRRGAPSANAQWGNNVAILAGDYLLATASRLVARLGPEAVRIIADTFAQLVTGQMRETRGTSENVDSIEQYLKVVQEKTGSLIGAAGRLGGMFSGATDEQVERLSRLGGVVGTAFQIADDIIDIDSESDESGKLPGTDVREGVHTLPMLYALRESGPDCARLRALLNGPVDDDAEVREALTLLRASPGMARAKDVLAQYAAQARHELALLPDVPGRRALAALVDYTVSRHG
Protein: Protein SMALL AUXIN UP-REGULATED RNA 8 (Q9SI60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Provide a mechanistic link between auxin and plasma membrane H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), and triggers PM H(+)-ATPases activity by promoting phosphorylation of their C-terminal autoinhibitory domain as a result of PP2C-D subfamily of type 2C phosphatases inhibition, thus leading to the acidification of the apoplast and the facilitation of solutes and water uptake to drive cell expansion (By similarity). Triggers plant growth probably by promoting cell elongation. Regulates branch angles and bending.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9FJG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9FJG1}.
Interaction partners:
- Auxin-responsive protein SAUR76
Sequence:
MSILKKSTKLAQTAMLRQILKRCSSLGKKNGGGGYEEVDLPLDVPKGHFPVYVGHNRSRYIVPISFLTNLDFQCLLRRAEEEFGFDHDMGLTIPCDELFFQDLTSMIR
Protein: Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (Q149R9)
Organism: Mus musculus (Mouse)
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 3
- Lysophosphatidic acid receptor 1
- Guanine nucleotide-binding protein subunit alpha-12
- Lysophosphatidic acid receptor 4
- Guanine nucleotide-binding protein subunit alpha-13
- Lysophosphatidic acid receptor 6
- Prothrombin
- Proteinase-activated receptor 1
Sequence:
MFANSSANTTSTNSSVLQCPDYRDTHRLHMVVYSLVLATGLPLNALALWVFLRVLRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYAQHHWPFPGFLCQTSGAIFQMNMYGSCLFLMLINVDRYAAIVHPLRLRHLRRPRVARRLCLGVWALILLFAVPAARVHSPSHCTYKNITVRLCFESFSDELWKGRLLPLLLLAEILGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLIIFLLCFVPYNSTLAVYGLLRANLVKNSIQDRDQVRGVLMIMVLLAGANCVLDPLVYYFSAEGFRNTLRNLGAPLNTRPLATNGAAGVLTELPSESTQNTGQDATSQVLLQPATLGTPPDNCSQDSAL
Protein: Elongator complex protein 5 (I3L437)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPTAGSPAA
Protein: Cystinosin homolog (P57758)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thought to transport cystine out of lysosomes.
Subcellular location: Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Probable receptor-like serine/threonine-protein kinase At4g34500
- Amino acid transporter AVT6C
- Uncharacterized protein At4g31330
- 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic
- NAD
- Sugar transporter ERD6-like 12
- Plasma membrane fusion protein
- Gamma-glutamylcyclotransferase 2-1
- Lupeol synthase 1
- Dual specificity protein kinase YAK1 homolog
Sequence:
MASWNSIPLEISYEIVGWIAFASWSISFYPQLILNFRRRSVVGLNFDFVMLNLTKHSSYMIYNVCLYFSPVIQKQYFDTYGDKEMIPVAANDVAFSIHAVVMTAVTLFQIFIYERGPQKVSRLAIGIVVVVWGFAAICFFIALPTHSWLWLISIFNSIQVFMTCVKYIPQAKMNFTRKSTVGWSIGNILLDFTGGLANYLQMVIQSIDQNSWKNFYGNMGKTLLSLISIFFDILFMFQHYVLYPEKKVSKSPETGEESNEPLIDSSHEHV
Protein: Acid beta-fructofuranosidase 3, vacuolar (At beta fruct3) (AtBETAFRUCT3) (EC 3.2.1.26) (Acid invertase 3) (AI 3) (Acid sucrose hydrolase 3) (Vacuolar invertase 3) (Inv-V3) (VAC-INV 3) (VI 3) (Q43348)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possible role in the continued mobilization of sucrose to sink organs.
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. Vacuole lumen {ECO:0000250|UniProtKB:Q39041}. Note=May be released into the lumen of the vacuole from the tonoplast through a proteolytic processing. {ECO:0000250|UniProtKB:Q39041}.
Interaction partners:
- alpha-D-xyloside xylohydrolase
- Probable galactinol--sucrose galactosyltransferase 4
- Probable fructokinase-1
- Probable fructokinase-5
- Probable fructokinase-3
- Probable fructokinase-4
- Probable fructokinase-2
- Probable fructokinase-7
- Probable fructokinase-6, chloroplastic
- Hexokinase-1
Sequence:
MASTEALLPVTSLQDPLSESRSDQIPETRRRRPIKVHLAVYSGLLLIALYVTLIVTHDGSKAEIATESRPRMAGVSEKSNDGVWISSDDGKVEAFPWNNTILSWQRTAFHFQPEKNWMNDPNGPLFYKGWYHFFYQYNPNAAVWGDIVWGHAVSKDLIHWLYLPIAMVPDQWYDANGVWTGSATFLDDGSIVMLYTGSTDEFVQVQNLAYPEDPSDPLLLKWVKFSGNPVLVPPPGIGAKDFRDPTTAWKTSSGKWRITIGSKINRTGISLIYDTTDFKTYEKHETLLHQVPNTGMWECVDFYPVSKTQLNGLDTSVNGPDVKHVIKASMDDTRIDHYAIGTYDDSNATWVPDNPSIDVGISTGLRYDYGKYYASKTFYDQNKGRRILWGWIGESDSEAADVQKGWSSVQGIPRTVVLDTRTHKNLVQWPVEEIKSLRLSSKKFDMTIGPGTVVPVDVGSATQLDIEAEFEIKTDDLKLFFDDDSVEADNKFSCETNGGSTARGALGPFGFSVLADEGLSEQTPVYFYVTKGKHSKLNTVFCTDTSRSTLANDVVKPIYGSFVPVLKGEKLTMRILVDHSIVEGFAQGGRSCITSRVYPTKAIYGATKLFLFNNAIDATVTASFTVWQMNNAFIHPYSSDDLGVPSST
Protein: ATP synthase protein MI25 (Q8HCR5)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004304}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004304}.
Interaction partners:
- H
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit a
- Os01g0899275 protein
- Os01g0899350 protein
- F-ATPase protein 6
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit alpha
Sequence:
MGLSSTDKKDRRNMLFAAILFICALSSKKILIYNEEMIVACCFIGFLIFSRKSLGKTFKETLDGRIESIQEELQQFFNPNEVILGESNEQQRLLRISLRICSAVVESLPTARCAPKCEKTVQALLCRNLNVKLATLLNAISSRRIRLQDDIVTGFHFSVSERFVSGSTFKASTVEQIREAFVPIDLIREGLIVLRKV
Protein: Hip1r protein (RCG21182, isoform CRA_b) (B5DFK5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSGPPAGEPVVVADLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNSLEAELEEQRKQKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSKLKEKHNELINTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQVKRESEMKMEEQSDQLEKLKRELVAKAGELAHAQEALSRTEQSGSELSSRLDTLNAEKEALSGAIRQREAELLAAQSLVREKEEALSQEQQRSAQEKGELQGRLAEKESQEQGLQQKLLDEQFAVLRGAAAEAEAILQDAVSKLDDPLHLRCTSSPDYLVSRAQAALDSVSGLEKGHTQYLASSEDASALVAALTRFSHLAADTIVNGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQTKLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDAVRRIEDMMNQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAASTAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPGEEEPSRPSPAPRSGATKKPPLAQKPSIAPRPDNQLDKKDGVYPAQLVNY
Protein: Growth-regulated alpha protein (C-X-C motif chemokine 1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Cleaved into: KC(5-72) (Hematopoietic synergistic factor) (HSF) (KC-T)] (P12850)
Organism: Mus musculus (Mouse)
Function: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.
Subcellular location: Secreted.
Interaction partners:
- C-X-C chemokine receptor type 2
- C-X-C chemokine receptor type 1
- C-X-C chemokine receptor type 4
- C-C chemokine receptor type 2
- Atypical chemokine receptor 1
- C-C chemokine receptor type 1
- C-C motif chemokine 5
- C-X-C motif chemokine 2
- CX3C chemokine receptor 1
- Stromal cell-derived factor 1
Sequence:
MIPATRSLLCAALLLLATSRLATGAPIANELRCQCLQTMAGIHLKNIQSLKVLPSGPHCTQTEVIATLKNGREACLDPEAPLVQKIVQKMLKGVPK
Protein: Tropomyosin-2 (Tropomyosin I) (P09491)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis.
Interaction partners:
- Myosin light chain alkali
- Troponin T, skeletal muscle
- Myosin regulatory light chain 2
- Tropomyosin-1, isoforms 9A/A/B
- Troponin I
- Myosin heavy chain, muscle
- Paramyosin, long form
- Muscle-specific protein 20
- Troponin C, isoform 2
- Actin-57B
Sequence:
MDAIKKKMQAMKLEKDNAIDKADTCENQAKDANSRADKLNEEVRDLEKKFVQVEIDLVTAKEQLEKANTELEEKEKLLTATESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEATQSADENNRMCKVLENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGESKIMELEEELKVVGNSLKSLEVSEEKANQRVEEFKREMKTLSIKLKEAEQRAEHAEKQVKRLQKEVDRLEDRLFNEKEKYKAICDDLDQTFAELTGY
Protein: DNA damage response protein D (Q9RXI7)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Function: Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation. May play a role in DNA repair and genome reconstitution.
Interaction partners:
- Single-stranded DNA-binding protein DdrA
- Single-stranded DNA-binding protein DdrB
- DNA damage response protein C
- DNA repair protein PprA
Sequence:
MDTLKKAGTMLAHLDLFHSMLDLRRLLQLAAYMKERGDRAMLISAGEITLIGSESMTAPEVVTSKGETIDAATAYRVLGQLEGYEAPEYAVNREALAALNARAVAELEGSEALRAFGDTLARISAAPTDPAGPERPGTDRAERTAAERTASERATHDRASTERPARPRRSAEPEAVRTEDAPQPNAEASEAGENTPAA
Protein: Acrosomal protein SP-10 (Acrosomal vesicle protein 1) (P26436)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Nascent acrosomal vesicle of Golgi phase spermatids.
Interaction partners:
- Transcription factor Sp9
- Activin receptor type-1
- Lipase member N
- Transcription factor Sp6
- Methyl-CpG-binding domain protein 3-like 2
Sequence:
MNRFLLLMSLYLLGSARGTSSQPNELSGSIDHQTSVQQLPGEFFSLENPSDAEALYETSSGLNTLSEHGSSEHGSSKHTVAEHTSGEHAESEHASGEPAATEHAEGEHTVGEQPSGEQPSGEHLSGEQPLSELESGEQPSDEQPSGEHGSGEQPSGEQASGEQPSGEHASGEQASGAPISSTSTGTILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNKI
Protein: UDP-galactose transporter senju (Q9VMU8)
Organism: Drosophila melanogaster (Fruit fly)
Function: UDP-galactose transporter involved in the synthesis of galactose-containing glycans. Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:25901322}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- IP10585p
- Uncharacterized protein, isoform C
- UDP-sugar transporter UST74c
- GDP-fucose transporter, Golgi
- Endoplasmic reticulum GDP-fucose transporter
- Solute carrier family 35 member B1 homolog
Sequence:
MSTNWRELFPTKLTFVIFLLYMSLFIGQGIFVTASQESNNSYGYNTVTVVLLTEVFKLIVSTCLYCRDNNLRSLVRDVQKDRNVLGLYMVPAFLYCLYNNLAFVNLATFDPTTYYLLLQLRVVVTGILFQIIFKKYLSQRQWISLILLTLGCMMKQVDFGSFYSDANDDSESAAIQQQLQSHNKTTSAETHAHGKNMSGFDFSLSAVFILAQTICSCLAGVYNEYLLKDKGADVNIFVQNVFMYLDSIVCNAVILLLRGELLDAFSPQNLGSIMRFSVLIIIVNNAAIGIVTSFFLKYMNSILKTFASALELLFTAVLCYFLFSIPIYMNTALAIAVVSYAIYLYTQSPVVNLGKVRPLSNLSDATTKSTDKRKLIDEEAAESDLDMV
Protein: Voltage-gated potassium channel regulatory subunit KCNG4 (Potassium voltage-gated channel subfamily G member 4) (Voltage-gated potassium channel subunit Kv6.3) (Voltage-gated potassium channel subunit Kv6.4) (Q8TDN1)
Organism: Homo sapiens (Human)
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:19074135). Colocalizes with KCNB1 at the plasma membrane (PubMed:19074135). Retains in the endoplasmic reticulum in the absence of KCNB1 (PubMed:19074135). {ECO:0000269|PubMed:19074135}.
Interaction partners:
- Potassium voltage-gated channel subfamily B member 1
- Ubiquitin-like protein FUBI
- Cone-rod homeobox protein
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-3
Sequence:
MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM