wanglab/gogpt-training-data huggingface dataset:
Protein: Protein strawberry notch homolog 2 (Q7TNB8)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade (By similarity).
Interaction partners:
Sequence:
MLAVEPTMDGDFPPHELPPPGGGIQLQNRLLHCPWWGSFSPSLYPTFSSENQQFVGSTPFLGGQSCPETSYPTTATVPSFFSKSSDFPQDPSCLEDLSNASVFSSSVDSLSDIPDTPDFLQADSLNEVPTIWDVSTTSTTHDKLFIPSGPFSAPEDPVTSLSSTPLLISYQSHSQPEEEEGEEEEETEELGHAETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPTSDNSTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEGVLFATYSALIGESQAGGQHRTRLRQILQWCGEGFDGVIVFDECHKAKNASSTKMGKAVLDLQSKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPAFQQVYNRAARLWAEALSVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEARTREVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGGKRKRRPRGRGPKASRLSLEAAGVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTHPTDDRGSLYPLQRDLQGPGVVERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKGRVVSRPDGTVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTDNRVPLPQGYPGGDTAFFRDMKQGLLSVGIGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKQISVDRGMKWEEALTRSLELKGPYDGFYLSYKVRGSKMSCLLAEQNRGEYFTVYKPNIGRQSQLETLDSLCRKFHRVTVEEAREPWESSYALSLEHCSHTTWNQRCRLTQEGKCCAQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIPEGCVHRVLQELQLMDAEVKRRSTHGLAARPPTPRAITLPCGPGEVLDLTYSPPAEAFPTPPRFAFPSLPPPDPSSLMLGARDPATNPVELAHQSCDINFREVLEDMLRSLRAGPTETPAPLVGVGGGGTERQSVIHFSPPFPNS
Protein: Protein RBL (COMPASS-like H3K4 histone methylation complex component RBL) (RBBP5-like protein) (AtRbBp5) (Retinoblastoma-binding protein-like) (Q5E915)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes the expression of FLC and FLC homologs to repress the floral transition. Promotes WRKY70 and LTP7 genes epigenetic methylation (e.g. H3K4me3) and subsequent expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:21423667}.
Interaction partners:
- Protein TRAUCO
- Multiple organellar RNA editing factor 1, mitochondrial
- Histone H4
- Flowering time control protein FY
- Histone-lysine N-methyltransferase ATX3
- Histone H3-lysine
- Histone-lysine N-methyltransferase ATX4
- Uncharacterized protein At5g66000
- Transducin/WD40 repeat-like superfamily protein
- Protein ANTHESIS POMOTING FACTOR 1
Sequence:
MNAPIIDPLQGDFPEVIEEYLEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNDCSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIARTILQQTPLQARLNPGLSSPSLCLACPLSSAPMIVDFDIDCTTLLPVSVPEMPDVLAPPQRSKCPESNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVRVLALVSASGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPAKNVLKSLEDLGKNIDGLDGIEKMKTVGSKCLTLFREFQDSVTKMHWKAPCFSGDGEWVVGGSACKGEHKIYIWDRAGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIWAKDYTENWSAFAPDFKELEENEEYVEREDEFDLIPETEKVKVLDVNEDEEVDIDTVEKDAFSDSDMSVEELRYLPAEPIPDTNDQQDNLVESIKLIEGQISASPASEEAGQNGHHASSPQAEEMGETRGKRKRKPSEKAMELQAEKAKPLKGSGKTVRAKNRAAFDQETDDSINGGDDDDDAYY
Protein: I71-7 (Q27320)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKLTVVCLVVSFFLLHYAEHSDACLEVIEKALGLQPCNEGGRNEHREPHRGGPGPVRSTRRRGRIPRRRETPRPIHHNTRERRHHTKTRKPRKPVPCITKRTEPPPVTDFTTRKSNPPCTCTESTTRKTNPTCTCTESTTKKTNPTCTCTESTTKKTNPTCTCTESTTPLTEPPVTDITTQKSNPPCTCTESTTRKTNPTCTCTESTTQKTNPTCTCTESTTKKTNPTCTCTESTTPLTEPPVTDITTQKSNPPCTCTESTTRKTNPTCTCTESTTRKTNPTCTCTESTTKKTNPTCTCTESTTPLTEPPVTDITTQKSNPPCTCTESTTQKIKSTSTTQGTEPPSTQKTLPPNPPSTKNTEPPNSTPPPEKTTRKPCGCSSSHPSGWNLAVL
Protein: Protein phosphatase 1M (EC 3.1.3.16) (Protein phosphatase 2C isoform eta) (PP2C-eta) (PP2CE) (Q8BU27)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000269|PubMed:14654243}.
Interaction partners:
Sequence:
MSAGWFRRRFLPGGPLPEPRPAGPRSSPVPYHRPRFLRGSGSSPGATDASRRPDARPVRSPARGRTLPWNAGYAEVINAEKSEFNEDQAACGKLCIRRCEFGIEEDQEWLTVCPEEFLTGHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGMIAPQPPMHLSGRCVCPSDPQFVEEKGIQAEDLVIGALENAFQECDDVIGRELEASGQVGGCTALVAVFLQGKLYVANAGDSRAILVRRHEIRQLSSEFTPETERQRIQQLAFTYPELLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMRGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGDHQLRVLDTDIQLKPFLLSIPQVTVLDVHQLAVQEEDVVVMATDGLWDVLSNEQVALLVRSFLTGNQKDDPHRFSELAKMLIHNTQGKDNGATGEGQVSYDDVSVFVIPLHSQAQEGSGH
Protein: CD3 glycoprotein (Q6PW00)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGKGRALGTWLLLACVAVAKLGVHGLSMSVKEVSGKVFLQCQESKDLNTNYLWKKGKEELGNMRQLDLGAIYDDPRGTYTCQRDENVNSTLHVHYRMCQNCIEVDAPTISGIVVADVVATVLLAIAVYCITGQDKGLMSRASDRQNLIANDQLYQPLGERNDGQYSQLATAKARK
Protein: Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (A0A8I6GKG1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU365053}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365053}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000256|RuleBase:RU365053}.
Interaction partners:
Sequence:
PGLALGRWRVRQDWEQSNYCLYVFLDRCGTQNLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGKDIVGFTDFCLFHWQT
Protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3) (O88705)
Organism: Mus musculus (Mouse)
Function: Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12928435, ECO:0000269|PubMed:15923185, ECO:0000269|PubMed:23382386}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
- PEX5-related protein
- Sodium channel protein type 5 subunit alpha
- Homeobox protein Nkx-2.5
- Gap junction alpha-5 protein
- Short stature homeobox protein 2
- T-box transcription factor TBX18
- Inward rectifier potassium channel 2
- T-box transcription factor TBX3
Sequence:
MEEEARPAAGAGEAATPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSEPSPGSSGGVMEQHLVQHDRDMARGVRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISANM
Protein: Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) (H7BXG7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}.
Interaction partners:
Sequence:
MVKLVLLSIVLLKVTVPKLSNDLLQLDFMPIHRGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKHIKEEKEESEFLPSSGGTFNISVSGDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKVVLTQANKLGV
Protein: Alhambra (Q7KSZ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSISTSGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSNATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSENLRLEEHVTSLIARRDHLLAVNARLQIPLSTIASNTKAEAHGK
Protein: Interleukin family protein (Q71UZ1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU368043}.
Interaction partners:
Sequence:
SPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
Protein: Frizzy aggregation protein FrzCD (Q1D4V7)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- histidine kinase
- Frizzy aggregation protein A
- protein-glutamate O-methyltransferase
- protein-glutamate methylesterase
- Frizzy aggegation protein B
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Chemotaxis protein CheW
Sequence:
MSLDTPNEKPAGKARARKAPASKAGATNAASTSSSTKAITDTLLTVLSGNLQARVPKELVGESGVELAHLLNQVLDQFAASEHRKHVAAQEIDQALDALIGLVREGDLSRWNTTTEDPQLGPLLEGFGKVIETLRTFVREINEAALRLSSSANQVLAASTQHETSSTEQAAAIHETTATMEELKHASAQIAENAGSVARVAEETLGAARAGRGAIGEFIQAMQQIRSDGVAVADSIAKLSKRVERIGTVVEVIDEIADRSDLLALNAALEGSRAGEAGKGFSIVAAEMRRLAENVLDSTKEIKNLITEIREATAAAAGAAEASKSATESGEKLGAVAAQAVEGILAGVQETSDAARVINLATQQQRTATEQVVASMAEIEDVTRQTTQASKQATGAAAELTQLAGRLAELIKRFKAD
Protein: YbjN domain-containing protein (P71842)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSRRAIHSGRAAPRRSGNSHLVLRNRVPSSKDSPRRRPHHEFMTESIGEPLSTNLIERYLRARGRRYFRGHHDAEFFFVANAHLRLHVHLEISPAYRDVFTIRVSPAYFFPATDHTRLAEIVNAWNLQNHEVTAIVHGSSDPHRIGVAAERSLIRDRIRFDDFATFVDNAVSAATELFGQLTAAGLPPTATPPLLRDAG
Protein: Photosystem II extrinsic protein U (PSII-U) (PsbU) (Photosystem II 12 kDa extrinsic protein) (PS II complex 12 kDa extrinsic protein) (Q55332)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation. May modulate the Cl(-) requirement for oxygen evolution.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00589, ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:34937700}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00589, ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:34937700}; Lumenal side {ECO:0000255|HAMAP-Rule:MF_00589, ECO:0000269|PubMed:34937700}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II reaction center protein I
- Photosystem II extrinsic protein V
- Photosystem II extrinsic protein O
- Cytochrome b559 subunit alpha
- Photosystem II D2 protein
- Photosystem II lipoprotein Psb27
- Photosystem II reaction center protein H
Sequence:
MKFISRLLVACSLLIGLMGFLGADLAQALTPNPILAELNAVDAKLTTDFGQKIDLNNSDIRDFRGLRGFYPNLASEIIKNAPYDTVEEVLDIPGLSETQKSRLEANLGSFTVTEPSIELTSGDDRINPGVY
Protein: 4-hydroxy-tetrahydrodipicolinate reductase (HTPA reductase) (EC 1.17.1.8) (P94844)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00102}.
Interaction partners:
- 4-hydroxy-tetrahydrodipicolinate synthase
- 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- Poly
- Glycolate oxidase subunit
- Diaminopimelate decarboxylase
- Diaminopimelate epimerase
- Aspartate-semialdehyde dehydrogenase
- Uncharacterized RNA pseudouridine synthase HP_0347
- Carbamoyl phosphate synthase small chain
- Nudix hydrolase domain-containing protein
Sequence:
MKIGVYGASGRIGKLLLEELKGGYKGLALSSVFVRQKCETDFSSFSHAPLVTNDLKAFVRACECVIDFSLPKGVDNLLEALLECPKILVSGTTGLEKETLEKMQQLALKAPLLHAHNMSIGIMMLNQLAFLTSLKLKDADIEIIETHHNLKKDIPSGTALSLYETCAKARGYDEKNALITHREGLRSKESIGIAALRGGDVAGKHTIGFYLEGEYIELSHTATNRSIFAKGALEVALWLKDKAAKKYEINEMFG
Protein: Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) (hNOTUM) (Q6P988)
Organism: Homo sapiens (Human)
Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
Interaction partners:
- Proto-oncogene Wnt-1
- Protein Wnt-7a
- Protein Wnt-3a
- Protein Wnt-11
- Protein Wnt-6
- Protein Wnt-16
- Protein Wnt-4
- Proto-oncogene Wnt-3
- Protein Wnt-5a
- Protein Wnt-7b
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
Protein: Uncharacterized protein (O69643)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MFTLLVSWLLVACVPGLLMLATLGLGRLERFLARDTVTATDVAEFLEQAEAVDVHTLARNGMPEALDYLHRRQARRITDSPPLGSGAGPRYAGPLFVTDLDSPVEPPRHGQPNPQFRTARHANHV
Protein: Interphotoreceptor matrix proteoglycan 2 (Interphotoreceptor matrix proteoglycan of 200 kDa) (IPM 200) (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan) (Q9BZV3)
Organism: Homo sapiens (Human)
Function: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.
Subcellular location: Photoreceptor outer segment membrane {ECO:0000269|PubMed:29777959}; Single-pass type I membrane protein {ECO:0000255}. Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:Q80XH2}; Single-pass type I membrane protein {ECO:0000255}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:10702256}.
Interaction partners:
- Protein eyes shut homolog
- Photoreceptor cilium actin regulator
- Photoreceptor disk component PRCD
- Zinc finger protein 513
- Ceramide kinase-like protein
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Bestrophin-1
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Retinol dehydrogenase 12
- Cyclic nucleotide-gated channel beta-1
Sequence:
MIMFPLFGKISLGILIFVLIEGDFPSLTAQTYLSIEEIQEPKSAVSFLLPEESTDLSLATKKKQPLDRRETERQWLIRRRRSILFPNGVKICPDESVAEAVANHVKYFKVRVCQEAVWEAFRTFWDRLPGREEYHYWMNLCEDGVTSIFEMGTNFSESVEHRSLIMKKLTYAKETVSSSELSSPVPVGDTSTLGDTTLSVPHPEVDAYEGASESSLERPEESISNEIENVIEEATKPAGEQIAEFSIHLLGKQYREELQDSSSFHHQHLEEEFISEVENAFTGLPGYKEIRVLEFRSPKENDSGVDVYYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTVVYTISNFRDYIAETLQQNFLLGNSSLNPDPDSLQLINVRGVLRHQTEDLVWNTQSSSLQATPSSILDNTFQAAWPSADESITSSIPPLDFSSGPPSATGRELWSESPLGDLVSTHKLAFPSKMGLSSSPEVLEVSSLTLHSVTPAVLQTGLPVASEERTSGSHLVEDGLANVEESEDFLSIDSLPSSSFTQPVPKETIPSMEDSDVSLTSSPYLTSSIPFGLDSLTSKVKDQLKVSPFLPDASMEKELIFDGGLGSGSGQKVDLITWPWSETSSEKSAEPLSKPWLEDDDSLLPAEIEDKKLVLVDKMDSTDQISKHSKYEHDDRSTHFPEEEPLSGPAVPIFADTAAESASLTLPKHISEVPGVDDYSVTKAPLILTSVAISASTDKSDQADAILREDMEQITESSNYEWFDSEVSMVKPDMQTLWTILPESERVWTRTSSLEKLSRDILASTPQSADRLWLSVTQSTKLPPTTISTLLEDEVIMGVQDISLELDRIGTDYYQPEQVQEQNGKVGSYVEMSTSVHSTEMVSVAWPTEGGDDLSYTQTSGALVVFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFANSVPPNVNNAVYMILEDFCTTAYNTMNLAIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAKCRCFPGYLSVEERPCQSLCDLQPDFCLNDGKCDIMPGHGAICRCRVGENWWYRGKHCEEFVSEPVIIGITIASVVGLLVIFSAIIYFFIRTLQAHHDRSERESPFSGSSRQPDSLSSIENAVKYNPVYESHRAGCEKYEGPYPQHPFYSSASGDVIGGLSREEIRQMYESSELSREEIQERMRVLELYANDPEFAAFVREQQVEEV
Protein: Probable peroxygenase 4 (AtPXG4) (EC 1.11.2.3) (Caleosin-4) (Q9CAB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies. May be involved in the interaction between oil bodies and vacuoles during seed germination (By similarity). Acts as a negative regulator of abscisic acid responses in non-seed tissues.
Subcellular location: Lipid droplet {ECO:0000305}.
Interaction partners:
- Cytochrome P450 86A1
- Cytochrome P450 704B1
- Protein HOTHEAD
- WD repeat-containing protein 76
- Acyl-CoA hydrolase 2
- Acyl-CoA thioesterase family protein.
- Very-long-chain enoyl-CoA reductase
- Cytochrome b-c1 complex subunit 10, mitochondrial
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
Sequence:
MASSISTGVKFVPEEDNFLQRHVAFFDRNKDGIVYPSETFQGFRAIGCGYLLSAVASVFINIGLSSKTRPGKGFSIWFPIEVKNIHLAKHGSDSGVYDKDGRFVASKFEEIFTKHAHTHRDALTNEELKQLLKANKEPNDRKGWLAGYTEWKVLHYLCKDKNGLLHKDTVRAAYDGSLFEKLEKQRSSKTSKKHP
Protein: ETS translocation variant 5b isoform 2 (ETS variant transcription factor 5b) (F1QK52)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Interaction partners:
- Sprouty homolog 4
- Arginine vasopressin-induced protein 1
Sequence:
MDGFYDQQVPFMVPPNKSHMQEPSCRTFNDRKRKFVDTELAQDTEELFQDLSQLQEIWIAEAQVPDDEQFVPDFQSDNLMFHGPPQTKIKREMSPSREFSPCGQEQRLSPYGEKCLYNYSAFDRKPFTFNKPLTPPSTPASPFGSSSTATHPVQKRAMPPAQTQTQGAPLLPGPNHSSTSPHQRAQTPLHSQSPPFAVPCTPVNHPDASYSTDHRFHRQLSEPCLPFPQSDGRCQTPYPPQTRGHFPRHSRPPYQRQMSEPLVPMPPQGFKKEMVDPRYNEQGVQNMGPPRAPLFHQLSIKQEPRDFGFDSEVQNCHSSFGKSSNFYGGNGEGFGYDGEAHLYYDDACVVPDRLEGKLKQEGGVFRDGPPYQRRGSLQLWQFLVTLLDDPSNGHFITWTGRGLEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPSLKAEPDSLQVPEDDTVPLSHFDEANRAPYPADARDQCLVVPSFPESYTF
Protein: Scavenger receptor class A member 5 (Q8K299)
Organism: Mus musculus (Mouse)
Function: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1).
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03070, ECO:0000269|PubMed:19154717}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_03070, ECO:0000269|PubMed:19154717}.
Interaction partners:
- Ferritin light chain 1
- Ferritin heavy chain
Sequence:
MDNKAMYLHTVSDRDNGSIFEEPFDGRSLSKLNLCEDGPCHKRRAGGCCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESLRDMQLRLLQAPLQADLTEQVWKVQDALQNQTDSLLALAGLVQRLEGTLWGLHAQAAQTEQAMALLRDRTGQQSDSAQLELYQLQVESNRSQLLLQRHAGLLDGLARRVGVLGEELADVGGALRGLNHSLSYDVALHSTWLQDLQVLVSNASADTRRMRLVHMDMEMQLKQELATLNVVTEDLRLKDWEHSIALRNITLAKGPPGPKGDQGNEGKEGKPGSPGLPGSRGLPGERGDPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGERGERAGDMDFTMIRLVNGSGPHQGRVEVFHDRRWGTVCDDGWDKKDGDVVCRMLGFHGVEEVYRTARFGQGTGRIWMDDVNCKGTESSIFHCQFSKWGVTNCGHAEDAGVTCTVP
Protein: Accessory protein 7a (Q19QW4)
Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV)
Subcellular location: Host Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004152}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004152}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004517}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004517}. Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004372}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004372}. Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MKIILFLTLIVFTSCELYHYQECVRGTTVLLKEPCPSGTYEGNSPFHPLADNKFALTCTSTHFAFACADGTRHTYQLRARSVSPKLFIRQEEVQQELYSPLFLIVAALVFLILCFTIKRKTE
Protein: Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (Q6PFL0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for the development of dopaminergic amacrine cells in the retina. May also negatively regulate the development of rod photoreceptor cells.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
Sequence:
MADVMNVGVNLEAFSQAINAIQALRSSVTRVFDFLKDGMKNKETLESREKVFITEFQENLQSVNRDLNELERLSTLVGRPSESHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASSLLNQQSLKRSANQMGTSAKRRPKVQPSTLALPTQYVDDVISRIGRMFPDMSIELFRPNGTSAVLLVTLGKVLKAIVVMRSLFIDRTIVRGFHENIYTEDRKLDIWSKSNYQAFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQTPCQRCGKYLQEGLPPTWRDFRTLEAFHDTCRQ