wanglab/gogpt-training-data huggingface dataset:
Protein: DNA primase large subunit (DNA primase 58 kDa subunit) (p58) (P33610)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit. Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch.
Interaction partners:
- DNA primase small subunit
- DNA polymerase alpha catalytic subunit
- DNA polymerase alpha subunit B
- DNA polymerase delta catalytic subunit
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase epsilon subunit 2
- DNA polymerase delta subunit 2
- DNA polymerase zeta catalytic subunit
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM3
Sequence:
MQFSGRIRKKLRLAGDQRNASYPHSLQFYLQPPTENISLTEFENLAFDRVKLLKAIENLGVSYVKGTEQYQSKLEAEIRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEDLRRWFIQQEMDLLRFRFSILPKDKVQSFLKDSHLHFEAISDEEKTLREQDIMASSPSLSGIKLESESVYKVPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRATLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQKNTGKISLDQIDSLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIRGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCMKIILTNPPGQGDYHGCPFRHSDAELLKQKMQSYKIPASGISQILDLVKGNHYQVACQKYFEMTHNVDDCGFSLNHPNQFFFESQRILTGGKDIKKEISQPETPQHKPSTQKTRDAASALASLDSSLEMDLEGLEEYF
Protein: GDP-L-colitose synthase (EC 1.1.1.356) (G4WJD3)
Organism: Yersinia pseudotuberculosis
Function: Involved in the biosynthesis of the L-colitose (3,6-dideoxyl-L-xylo-hexose) present in the O-antigen region of lipopolysaccharides (LPS) where it serves as antigenic determinant and are vital for bacterial defense and survival. Catalyzes the two-step NADP-dependent conversion of GDP-4-keto-3,6-dideoxy-D-mannose to GDP-L-colitose. ColC is a bifunctional enzyme catalyzing the C-5 epimerization of GDP-4-keto-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose. It can use both NADP(+) and NAD(+) as electron acceptor, with a slight preference for NADP(+).
Interaction partners:
Sequence:
MKILLTGAGGMVGKNILAHTKSKDYEFITPSSKELDLLEKKHITTYLKHHKPNFIIHAAGIVGGIHANINNPVKFLVENMQMGINLLTAAKDNNIRKLLNLGSSCMYPKDCDSGLTEDMILTGELESTNEGYALAKITSAKLCEYINREDSEFQYKTAIPCNLYGKYDKFDENNSHMIPAVIKKIVTAIETGKSEVEIWGDGEARREFMYAEDLADFIFYTINNFTKMPQNINVGLGQDYTITEYYKVIAKILGYKGTFVYDKSKPVGMRRKLIDNTLLSEFGWSNKVDLESGISKTCQYFLNEKNND
Protein: Ski oncogene (Proto-oncogene c-Ski) (P12755)
Organism: Homo sapiens (Human)
Function: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.
Subcellular location: Nucleus.
Interaction partners:
- Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Nuclear receptor corepressor 1
- Ski-like protein
- Mothers against decapentaplegic homolog 1
- E3 ubiquitin-protein ligase Arkadia
- SNW domain-containing protein 1
- Mothers against decapentaplegic homolog 5
- Paired amphipathic helix protein Sin3a
Sequence:
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELEP
Protein: Oligouridylate-binding protein 1A (AtUBP1a) (Polyuridylate-binding protein UBP1A) (Poly(U)-binding protein UBP1A) (Q9SYG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as a component of the pre-mRNA processing machinery. Functions to facilitate the nuclear maturation of plant pre-mRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ribonuclease TUDOR 2
- Ribonuclease TUDOR 1
- Ubiquitin carboxyl-terminal hydrolase 1
- Small nuclear ribonucleoprotein SmD1a
Sequence:
MQNQRLIKQQQQQQQQQHQQAMIQQAMMQQHPSLYHPGVMAPPQMEPLPSGNLPPGFDPTTCRSVYAGNIHTQVTEILLQEIFASTGPIESCKLIRKDKSSYGFVHYFDRRCASMAIMTLNGRHIFGQPMKVNWAYATGQREDTSSHFNIFVGDLSPEVTDAALFDSFSAFNSCSDARVMWDQKTGRSRGFGFVSFRNQQDAQTAINEMNGKWVSSRQIRCNWATKGATFGEDKHSSDGKSVVELTNGSSEDGRELSNEDAPENNPQFTTVYVGNLSPEVTQLDLHRLFYTLGAGVIEEVRVQRDKGFGFVRYNTHDEAALAIQMGNAQPFLFSRQIRCSWGNKPTPSGTASNPLPPPAPASVPSLSAMDLLAYERQLALAKMHPQAQHSLRQAGLGVNVAGGTAAMYDGGYQNVAAAHQQLMYYQ
Protein: Sperm associated antigen 9 (A0A8I5Y1R0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSEQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGLVKGTDTPNKAEISKHIEVQVAQETRNVSTDSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFMPTRFSRLFSSSSNAAKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVANGQGENKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVSALESEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSDSGQVDRASLCGSMTSNSSAEMDSLLGGITVVGCSTEGVTGAAASPSTNGASPVIEKPPEVEAENSEIDENIPTAEEATEATEGNAGSTEDAVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGLDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETVILHQGRLLGLRANKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVVSPQSSSSGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
Protein: Zinc finger protein 653 (67 kDa zinc finger protein) (Zinc finger protein Zip67) (Q96CK0)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear receptor subfamily 5 group A member 2
- Steroidogenic factor 1
Sequence:
MAERALEPEAEAEAEAGAGGEAAAEEGAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPDSDKVGNGLVAGSSDSSSSGSASDSEESPEGQPVKAAAAAAAATPTSPVGSSGLITQEGVHIPFDVHHVESLAEQGTPLCSNPAGNGPEALETVVCVPVPVQVGAGPSALFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNMAAGSGVPGSGLGEEVPCAMMEGVAAYTQTEPEGSQPSTMDATAVAGIETKKEKEDLCLLKKEEKEEPVAPELATTVPESAEPEAEADGEELDGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCDRCGKRFEKLDSVKFHTLKSHPDHKPT
Protein: Riparin-1.1 (P86124)
Organism: Crinia riparia (Streambank froglet) (Flinders Ranges froglet)
Function: Induces mouse splenocyte proliferation through binding to CCK-BR.
Subcellular location: Secreted {ECO:0000269|PubMed:16470724}.
Interaction partners:
Sequence:
RLCIPVIFPC
Protein: GBP21 (P90629)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MIRLACLRGPAMRSAWSRGASTFSGVQSLPKFEIHDVRDDPALGTMTRVAVDGKLLLISQYPQLGPRKVDPNDLSPQFDADRRISVRLRHVDLAYLVGVCKERVPRHRMETKAYTLDFEKSAQGYHLHGKVHRVASQRMEDWSVKFDNHFAVTLEHFLESALDESFGFRQHYATRAAEGGEKIAATSSAEGGARRKRSVSDTSRYH
Protein: Dpr-interacting protein alpha, isoform B (M9PGE1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCQLNTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGPNRNKNPLNGGGKGGGAGGSLDADANDILKQKQQVKVTYQPEDEELQYGSVEDFEAEGGEGGGLTPLSPHVYYTSGNKPATHKPGNSGGNQHLHQQHHHHHHHNNNNNNQQHSGGPGGGPTGGDAGSLGGEMGGITRKPPPYYGGNTEVRGPIDNNEMSSGSGDSRLCRGHHLPILLLPFARLILVRSWHCRHTFLMGLSQACLPGLLLSLL
Protein: Zinc finger protein YGR067C (P53243)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein YPR022C
Sequence:
MAAGQKKYICSFCLKPFSRSEHKIRHERSHAGVKPFQCQVCKHSFVRRDLLQRHIRTVHRTFLLSSYASMTGDKADIPVSLGVGDVDSTSPRDIKMETLVNSMIKVNSGLINIHYHSSNVEKMDKQQRCVIGKESSSLKKGKSRFKQVKSRLESSISVKILQEYSLDFISSRDILTFFRMGVSHLVENKIFQNFFPDLFSSLQNDELVESFWINKPFGLIIACLGMSISLNQDSQKLWFICCTNLYASSSKHDNDFDTEDILSQTEQHDVFALILFYSLLVMLENNIPVSNSIKKFDVFSMLQDILKPFTVASSSYHYLNSKENAWFIFDLWVNILRDSNNFNNDSLLIFGWFVNQEFISSNPLKDFIYKGPSMSTTDLTLKHINILADSAYVYFIIKKTYPQELPSDFRVHDLLVYLNECFVMQQPIKPETSANPSLFANVMNARITDCKSKSNWLLWETIWFEFINNLTLRNGTTRNIWFIDNFPQVSTSCLLHHSSSFVDETLITTNLSIISMLLNLKSFTLASLNPRNIQLITDIVSFQLKLFSSELIASSDVSPSQVSQLLVNPNVHLMLYFWFDTIYVQRQSYLSSTEKEEFEKVEVFVNDYIITHQKNLVTDLHSILFDFWSDSFIAYHILLHAIVSSLRDNILYPYLIYSPHLNDQTKALLTDISNWSCFALQQPFRKTSRGSLSGASDMKSFSVASCLPLSPNFLKRDSNCNKILLPPLDIKAIEPISTSNYTYVNSAPKQQEKEQPLLRATGNNINLVQTIVVPPQVNMESQEFSASSTDNKQSKNIEIFSQIK
Protein: Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) (A6NEL2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRGDGHISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPSPRVDAGLSLKLAEVKAVVAERGWRHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEWIVKLASGSWIQVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGAPRGKPIFPVYPLVGSSSPTRKAKSKEISRSVTRKTSFAALLKSQHNKWKLANQYEKFHSPREREEYSD
Protein: Uncharacterized protein C11D3.14c (Q10093)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein C11D3.15
- Glutamate--cysteine ligase
- Putative glutamate--cysteine ligase regulatory subunit
- Glutathione hydrolase proenzyme 2
- Glutathione-specific gamma-glutamylcyclotransferase
- Glutathione hydrolase proenzyme 1
- Cys-Gly metallodipeptidase dug1
- Putative aminopeptidase C13A11.05
- NADP-specific glutamate dehydrogenase
- Probable NAD-specific glutamate dehydrogenase
Sequence:
MKQDVRIAIDRGGTFTDVYYKISGWREQEGIFKLLSVNPKLYDDAPTEGIRRVLCYASGEEIPRKVPLDLTRVSSIRMGTTVATNALLERKGEKTAFIITEGFRNLVEIGNQARPDLFDLTVSRPSPLYQRVIEAKERVVLENQFSKTAGIVQGITGEFLRVEKKLDEEALYQDLKELYNEGFRSISVSLMHSYTYPLHEEVVEKIAKRIGFTDISLSSKLTPMVKIVPRAVSAIIDAYLSSTLRYYLDSFKKNFYNVKPNTIQFMKSDGGLVDIDNFTAISAIMSGPAAGTVGFAKTSSLHADDKTPAIGFDMGGTSTDVSRYDGKFEHIYEANIFGLYIQSPQLDIQTVAAGGGSRLFWRNQLFSVGPESAGAFPGPACYLNGGPLTVTDANVLLGRIIPDFFPKIFGPKENESMNKDIVIEKFSELRDIINIDIEKEKTIEEIAMGFIQVANETMCRPIRKLTESRGLDLSAHHLAVFGGAGGQHACAIASLLNIEKIIIHKYSSVLSAYGLALAHVTHEEQMPCLSVLDEDNLPLIQSKFDVLDKKAVSFLENEGYLESQISTELFANLRYEGNDTTMMIAKPKDSWDFKTLFEESYKNQFGFSLIDRKIMVEDIRIRAIARASNQSEVDTVFASETENENTVFIRDNKPTMYTPVYFAEVGKVNCHVYQLSSLPVHSLITGPAVIVDTTQTLLIEPSFTAKIFARHVLLEKTKSTLVVKKNVDLDPITMTIFANRFMSISEQMGQVLQKTAVSVNVKERLDYSCALFSPDGGLVANAPHVPAMLGSMQTAVKWQHNYWKGKLVPGDVLLSNHPIAGGVHLPDLTVVTPVFDNNKDIIFYCAARGHMVDVGGITPGSMPSNSKAIYEEGAAIKTFKVVKAGTFDEKGLTQLLFDEPAKYPDCSGSRTLRDNISDVKAMLSACHRGRSMVEKLVVEYGLDIVQRSMYGIQAAAEKAVRDVLKAFSVQNSQKPLKAIDYMDDGTPLQLEVKIDPETGDAVFDFEGTGPEVYGNWNAPIAITYSSVIYCLRSIINQDIPLNEGCLKPIEIRIPPSCFLNPSETAAVVGGNVLTSQRITDVILKAFSICAASQGCMNNLTFGYDGENGEEGFAMYETIAGGAGAGPTWNGTSGVHTHMTNTRITDPEVVERRAPVILRRFCLRENSGGKGEYHGGDGVIRHFEFRRSMHCSILSERRSRAPYGMNGGEDGAMGVNTWIDCSNPDFPRYVNLGGKNHVLMGKGDHIVIETPGGGGYGAVSI
Protein: ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) (Q8N6H7)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17760859}. Golgi apparatus membrane {ECO:0000269|PubMed:17760859}; Peripheral membrane protein {ECO:0000269|PubMed:17760859}; Cytoplasmic side {ECO:0000269|PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Interaction partners:
- Coatomer subunit beta
- Coatomer subunit beta'
- ADP-ribosylation factor 1
- Coatomer subunit alpha
- ADP-ribosylation factor GTPase-activating protein 1
- Coatomer subunit delta
- Coatomer subunit zeta-1
- Coatomer subunit gamma-1
- Coatomer subunit gamma-2
- ADP-ribosylation factor 5
Sequence:
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANATAFFRQHGCTANDANTKYNSRAAQMYREKIRQLGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTEHTQPPAWDAPATEPSGTQQPAPSTESSGLAQPEHGPNTDLLGTSPKASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNRREVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSRLQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY
Protein: Lysine-specific demethylase 7 homolog (ceKDM7A) (EC 1.14.11.-) (JmjC domain-containing protein 1.2) (PHD finger protein 8 homolog) (PHF8 homolog) (Q9GYI0)
Organism: Caenorhabditis elegans
Function: Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9', 'Lys-23' and 'Lys-27' (H3K9me2, H3K23me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress-induced longevity.
Subcellular location: Nucleus {ECO:0000269|PubMed:20346720}.
Interaction partners:
- Lysine-specific demethylase jmjd-3.1
- Histone H3
- Histone H3.3-like type 2
- Histone H3.3 type 1
- LIN-65L
- JmjC domain-containing protein
- JmjC domain-containing protein
- Lysine-specific demethylase 4
- JmjC domain-containing protein
- Histone H4
Sequence:
MDGNDINIQKNEFSRDQSALLMMDQHSDHKNHESAIGEPGMSYTASQPALSSTEHQTPLVSEASVAAPQNHLNGNSHESVSEMDRNSVDFAIESVLMKARAYNKMGAPKDPRRKQHNPKSEPKIEPHVTDSSDNQAAMSNKMEAEAPKMESNQNYVSNGSEPPFRFVSISNFDEMKTKKKEVQEELKLEVDSDSEEDDVPEQKTPKESDRCGGCGKFTHEDDLIALEEEKKKEKEKPLMSKKKSHHHKKNDFQWIGCDSCQTWYHFLCSGLEQFEYYLYEKFFCPKCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSKTWIEDFITRENTVPSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQEKNIWTASQIMKAEMERWMDRELRLGPEKNAILPTDDKNKIMISVRKQIEIQTKIQNAKNKPMGLKQKRKSRESAERDDEDYCPSSSTAYKKKYTKKAKKDNDDAPKVKKAKKEEVPEEKVPVPEAAGPSEVTAPLTIKIGMGPTEDQKGVVQIFNNQCTSSGRKVKLNQNVADYCGSHLEARVEEIPEKATKSFRELDNELERCEAVHSGEKIKKVKEPKPPKQPKEKKEKPPPKKKEMSSRDRLMKKLKM
Protein: Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (SP18) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] (P17742)
Organism: Mus musculus (Mouse)
Function: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62937}. Secreted {ECO:0000250|UniProtKB:P62937}. Nucleus {ECO:0000250|UniProtKB:P62937}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation. {ECO:0000250|UniProtKB:P62937}.
Interaction partners:
- Apoptosis-inducing factor 1, mitochondrial
- Basigin
- Actin, cytoplasmic 1
- Ran-specific GTPase-activating protein
- Elongation factor 1-alpha 1
- Heat shock protein HSP 90-beta
- Polyubiquitin-B
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein uL3
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MVNPTVFFDITADDEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGDFTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITISDCGQL
Protein: Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) (Q969S3)
Organism: Homo sapiens (Human)
Function: Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11802789}. Nucleus {ECO:0000269|PubMed:11802789}.
Interaction partners:
- Eukaryotic translation initiation factor 6
- 60S ribosomal export protein NMD3
- Proliferation-associated protein 2G4
- Large subunit GTPase 1 homolog
- Maternal embryonic leucine zipper kinase
- Ribosomal protein uL16-like
- Myb-related protein B
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL24
Sequence:
MATYTCITCRVAFRDADMQRAHYKTDWHRYNLRRKVASMAPVTAEGFQERVRAQRAVAEEESKGSATYCTVCSKKFASFNAYENHLKSRRHVELEKKAVQAVNRKVEMMNEKNLEKGLGVDSVDKDAMNAAIQQAIKAQPSMSPKKAPPAPAKEARNVVAVGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQQEEDSEEEEEDLDGDDWEDIDSDEELECEDTEAMDDVVEQDAEEEEAEEGPPLGAIPITDCLFCSHHSSSLMKNVAHMTKDHSFFIPDIEYLSDIKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDHKEGEDPNKAEELPSEKNLEYDDETMELILPSGARVGHRSLMRYYKQRFGLSRAVAVAKNRKAVGRVLQQYRALGWTGSTGAALMRERDMQYVQRMKSKWMLKTGMKNNATKQMHFRVQVRF
Protein: AT4g21580/F18E5_200 (Oxidoreductase, zinc-binding dehydrogenase family protein) (Putative NADPH quinone oxidoreductase) (O65423)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKAIVISEPGKPEVLQLRDVADPEVKDDEVLIRVLATALNRADTLQRLGLYNPPPGSSPYLGLECSGTIESVGKGVSRWKVGDQVCALLSGGGYAEKVSVPAGQIFPIPAGISLKDAAAFPEVACTVWSTVFMMGRLSVGESFLIHGGSSGIGTFAIQIAKHLGVRVFVTAGSDEKLAACKELGADVCINYKTEDFVAKVKAETDGKGVDVILDCIGAPYLQKNLDSLNFDGRLCIIGLMGGANAEIKLSSLLPKRLTVLGAALRPRSPENKAVVVREVEKNVWPAIEAGKVKPVIYKYLPLSQAAEGHSLMESSNHIGKILLET
Protein: LIN1-like protein (O94693)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Pre-mRNA-splicing factor brr2
- A1 cistron-splicing factor aar2
- Pre-mRNA-splicing ATP-dependent RNA helicase prp28
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor spp42
- Small nuclear ribonucleoprotein-associated protein B
- Mitosis protein dim1
- Pre-mRNA-splicing factor cwf17
- Pre-mRNA-splicing factor prp1
- Probable urea active transporter 1
Sequence:
MKRTLRNPGNSSTVGDVHDVFFEYDVSNVGRKRPRTKEEGYYESESEEDEDQILNKEKKEGQSEDMFSDTSEDEKRTLPNDEAQKRRDFIENGDAERLAHKGLRNKEVLNDDSDDEDDNGKYSKLRYEDIEGQEDTNQANDLDADEEGSEISVPSSPKRMSFNLKEDMEEGDFDENGNFIRKNYDPESQYDAWLNGSVSNKKSIAAAREAEQKRKEMENRRRNQELEEFSKLPFSTVPEALSFFIARMERDESILEFLQRQSGNKKSYKKKKNNTAEGISPERKSADAFRKKLIELITAGLTFLEDKIGKEDIYSETRESLQRIYQKLTSNSWSSPVSYDDSNSSQYNFKWEFDDKTYGPYTASQIQAWSNEGYFTDAKHAAFIQLANMDEWMYPNNICFCDVVSLKK
Protein: FI21274p1 (Trap1, isoform A) (Trap1, isoform B (EC 3.6.1.3)) (A1Z6L9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Stress-induced-phosphoprotein 1
- Hsp90 co-chaperone Cdc37
- Cytosolic Prostaglandin E synthase
- LD43819p
- Serine/threonine-protein kinase Pink1, mitochondrial
- protein-serine/threonine phosphatase
- Hsc70Cb, isoform G
- FI03495p
- 10 kDa heat shock protein, mitochondrial
- CG9617 protein
Sequence:
MSVRAMGVLGQACRLGRCAQVLRQSHRSAPAAFNITIGSQHSPGALSLRRYSTETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKTDCREYADEERIKAVIKKYSNFVGSPILLNGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHALLYFPEGKPGLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFESSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVEKEMREESKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNRFALLQPELEINPKHPIIKKLNKLRESDKDLAQLIAKQLFANAMVGAGLAEDPRMLLTNMNTLLSRALEKY