wanglab/gogpt-training-data huggingface dataset:
Protein: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (P63092)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P63094}; Lipid-anchor {ECO:0000250|UniProtKB:P63094}.
Interaction partners:
Sequence:
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Protein: Aminoacylase, putative (Peptidase M20/M25/M40 family protein) (Q9C6Y8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ornithine transcarbamylase, chloroplastic
- Arginine biosynthesis bifunctional protein ArgJ
- Acetylornithine aminotransferase, chloroplastic/mitochondrial
- Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
- Arginase 1, mitochondrial
- Arginase 2, chloroplastic/mitochondrial
- Acetylornithine deacetylase
- N-acyl-aliphatic-L-amino acid amidohydrolase
- At1g44820
- Argininosuccinate synthase, chloroplastic
Sequence:
MAVSLLLWTLFLFSFIFSLQSHSKEEEEDTPITRFQQYLRFNTAHPNPNYTAPISFLLDQARSIGLTSRTIEFVPGKPVLLLTWLGSNLNLSSILFNSHLDSVPAESEKWIHPPFSAHRTIDGHIYARGAQDDKCIGVQYLEAIRNLKSRSFSPLRTIHISYVPEEEIGGFGGMMKFAASSEFKDLNLGFVMDEGQASPGDEFRVFYAERTPWHLAIRANGMPGHGAKLYDNSAMENLMKSVELISRFRESQFDFVKAGKAANSEVISVNPVYLKAGTPSTTGFVMNMQPSEAEVGYDLRLPPMADPVALKKRIAEEWAPSIRNMTYTLKQQGKLTDHLGRPIMTTTNDTNPWWSIFKQAVEATGGKLAKPEILISTTDSRFIRTLGIPVLGFSPMINTPILVHDHNEFLKDTVFMKGIGVYESVISALSSFEAA
Protein: Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7) (Q96RP8)
Organism: Homo sapiens (Human)
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q17ST2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Transient receptor potential cation channel subfamily M member 4
- Ankyrin repeat and SOCS box protein 18
- Voltage-gated potassium channel subunit beta-3
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-2
- Sodium channel protein type 4 subunit alpha
- Sodium channel regulatory subunit beta-1
Sequence:
MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVTEV
Protein: At2g18860 (Syntaxin/t-SNARE family protein) (Q501A1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046280}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00046280}.
Interaction partners:
- Putative syntaxin-24
Sequence:
MMVVNSFDLWQKDVFFSAAEEVQKSTDIMESAYRLWIREKKDEICKELQAALGTAKWQLEEFEKAVRLSHKRCGDNDSSSTRHKQFVTAIENQIHRVETSLQEAYSENGKKPLRWVDLNEEERDDLAMFLSGSSRTSQSFSGESSIKSRESTNSSLVENVMEVSAKVTFKKAKVYGDGSECVIDIEERVTPGQAEKSVGLRRIWSSPNFNSLRIIVPGGDNEEEKETLVAQIEATPKVKGTKSVLWMQRLPDHNQLFDKTGCFQNPIRLPFNHPIKFIVSLLLMVFLLLPFVVYLS
Protein: Gb|AAF16529.1 (Plant thionin family protein) (Q9LHT2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription factor MYB120
- Transcription factor MYB97
- Mediator of RNA polymerase II transcription subunit 12
- Transcription factor MYB101
Sequence:
MATQTIKKIYSVLMIVVLLTMIVSTYASTVEVCVKHCVPNQCMKVSQKATLPLCETACTKLCNENKHEEYVVPRSYCNGLFWFLCDT
Protein: Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) (Q8IW19)
Organism: Homo sapiens (Human)
Function: Histone chaperone involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1. Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity). Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:17507382, ECO:0000269|PubMed:23689425}. Chromosome {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:18474613, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425, ECO:0000269|PubMed:27063109}. Cytoplasm, cytosol {ECO:0000269|PubMed:17353262}. Note=Localizes to DNA damage sites (PubMed:18172500, PubMed:18474613, PubMed:21211721, PubMed:21211722, PubMed:23689425). Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (PubMed:18172500). {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:18474613, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425}.
Interaction partners:
- DNA repair protein XRCC4
- DNA repair protein XRCC1
- X-ray repair cross-complementing protein 5
- Aprataxin
- X-ray repair cross-complementing protein 6
- E3 ubiquitin-protein ligase CHFR
- DNA ligase 3
- DNA ligase 4
- Poly [ADP-ribose] polymerase 1
- Core histone macro-H2A.1
Sequence:
MSGGFELQPRDGGPRVALAPGETVIGRGPLLGITDKRVSRRHAILEVAGGQLRIKPIHTNPCFYQSSEKSQLLPLKPNLWCYLNPGDSFSLLVDKYIFRILSIPSEVEMQCTLRNSQVLDEDNILNETPKSPVINLPHETTGASQLEGSTEIAKTQMTPTNSVSFLGENRDCNKQQPILAERKRILPTWMLAEHLSDQNLSVPAISGGNVIQGSGKEEICKDKSQLNTTQQGRRQLISSGSSENTSAEQDTGEECKNTDQEESTISSKEMPQSFSAITLSNTEMNNIKTNAQRNKLPIEELGKVSKHKIATKRTPHKEDEAMSCSENCSSAQGDSLQDESQGSHSESSSNPSNPETLHAKATDSVLQGSEGNKVKRTSCMYGANCYRKNPVHFQHFSHPGDSDYGGVQIVGQDETDDRPECPYGPSCYRKNPQHKIEYRHNTLPVRNVLDEDNDNVGQPNEYDLNDSFLDDEEEDYEPTDEDSDWEPGKEDEEKEDVEELLKEAKRFMKRK
Protein: Tripartite motif-containing protein 30A (Down regulatory protein of interleukin-2 receptor) (Tripartite motif-containing protein 30) (P15533)
Organism: Mus musculus (Mouse)
Function: Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- 26S proteasome regulatory subunit 8
- Proteasomal ubiquitin receptor ADRM1
- 26S proteasome regulatory subunit 4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Interferon regulatory factor 7
- Interferon-induced protein 44
- Sequestosome-1
- GTP-binding protein
- Receptor-transporting protein 4
- Nuclear autoantigen Sp-100
Sequence:
MASSVLEMIKEEVTCPICLELLKEPVSADCNHSFCRACITLNYESNRNTDGKGNCPVCRVPYPFGNLRPNLHVANIVERLKGFKSIPEEEQKVNICAQHGEKLRLFCRKDMMVICWLCERSQEHRGHQTALIEEVDQEYKEKLQGALWKLMKKAKICDEWQDDLQLQRVDWENQIQINVENVQRQFKGLRDLLDSKENEELQKLKKEKKEVMEKLEESENELEDQTELVRDLISDVEHHLELSTLEMLQGANCVLRRSQSLSLQQPQTVPQKRKRTFQAPDLKGMLQVYQGLMDIQQYWVHMTLHARNNAVIAINKEKRQIQYRSYNTVPVSEIYHLGVLGYPALSSGKHYWEVDISRSDAWLLGLNDGKCAQPQLHSKEEMGIKKNLHSQIKQNVLFQPKCGYWVIGMKNPSVYKAFDECSITHNSSILVISLPDRPSRVGVFLDRKAGTLSFYDVSNCGALIYRFYDPAFPVEVYPYFNPMKCSEPMTICGPPS
Protein: F-box domain-containing protein (Q2YS43)
Organism: Caenorhabditis elegans
Interaction partners:
- Female germline-specific tumor suppressor gld-1
- Sex-determination protein fem-3
- FOG-1 protein
- Innexin-14
- Sex-determining transformer protein 2
- Spermatocyte protein spe-8
- EGF-like domain-containing protein
- Glycine-rich cell wall structural protein
- Protein glp-1
Sequence:
MSENLTDELDLMKISGPPSFSDMPMETVYKIVGKVDPYSRLAVRKVCRNLRNVIDDTDPGFKYVKVDLSRYASRLWLTNIGRGAICYSRNSNDPGCTVRRTSQSKSIEKTQLDAILDDLAVIVKNPKLRLDNFVIVSSHEASKQFVEWIRDIAQSGILLHTKKIKLDIFPLKDVFGVLSHCKPGFLEDIEFYCYDSAGKMDEIINLEQWKRAKSINIEGRVCEDIPIEHFFHFSRITIKLRKLSVSDAIKIRDDLMKSAHFEYAYIKIIEGVDPDVLRAINPNYHPYDALDPFEHGNYTFRISSDSLFDSALKIEKVSITEDDLALL
Protein: Leucine carboxyl methyltransferase 1 (A0A0U1RPZ5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRLNCFFMAAAAVAARQAGGGELGTVWRVLPTSLPGPGGGDGGYNSAPPLAASLPASPPAPTTSWAEPSRKRPKPERWNRFAVSIGYWHDPYIEHLVRQSKERKAPEINRGYFARVHGVSQ
Protein: Amiloride-sensitive Na+ channel (FI02125p) (Pickpocket) (Q7KT94)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Pickpocket 29, isoform D
- Transient receptor potential cation channel subfamily A member 1
- Piezo-type mechanosensitive ion channel component
- Pickpocket protein 11
- Sodium channel protein Nach
Sequence:
MAEIREDEEEKKSGISILPGPELLALPGFDTRASIASAALSDVPSDVIIKSRIRYGSPLSACKGLLLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLKWQESPVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARMAVAMHICDSEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGPFCKWNGRFYFCDKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKDINCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSRLSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCMRICGSCRDRRKHKIQQQNSVDLPEEKSEN
Protein: Uncharacterized membrane protein C24H6.13 (Q09766)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as an osmosensitive calcium-permeable cation channel.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSDSSSSSTSAFVSSLVFNFAIFCAFIGLFLCLRPREKHVYQPRCIIDTQPKEEKPEPSPSSPFGLFAYVVKRSETYLIQYAGVDGYFFIRYLFTFGALCILGCLVLFPILLPVNATNGVGEKGFDILSFSNVKNHNRFYAHVFLSWLFFGFTIFIIYRELRYYVIFRHAMQSSGLYNNLPSSSTMLLTELPNSVLNDEETLHELFPNASEFTCVRDLKKLEKKVKKRSDLGNKYESTLNSLINKSVKKHNKLVKKHKPLPSTLDYTAYVKKRPTHRLKFLIGKKVDTIDYCRDTIAELDEVVDKLQTSLEERKKVGSVFIRFRSQTDLQTAYQAFLYSKKFRKYRFGRALVGIAPEDIVWSNLDLSMYTRRGKKTISNTILTLMIIFWAFPVAVVGCISNVNYLIEKVHFLKFIDHMPPKLLGIITGILPSVALSILMSLVPPFIKFLGKFGGALTVQEIENYCQNWYYAFQVVQVFLVTTMTSAATSAVVQVIKEPASSMTLLASNLPKASNFYISYFLLQGLSIPGGALLQIVTLLLSKVLGRIFDNTPRKKWNRWNQLSAPSWGTVYPVYSLLVTIMICYSIIAPIIIGFAAVAFVLIYFAYSYNLIYVLGHNADAKGRNYPRALFQVFVGLYLAEVCLIGLFVLAKNWGATVLEAVFLGFTVACHLYFKYKFLPLMDAVPISAIESVSERPEIKYPMDLGTSEMKNVGRAYPEILEKLSSSSGSDEFLETSSRTSENTKEKIDKDDEGFAITNISSVHKMPSFVLSYFSDLAASNRILTGFDRVLQLLPSFYDIPVRVRNVQYVSPALKATPPSVWIPKDPLGLSTYAIEDARGKVDIFDDNTTFNEKGNLQYTGPPPDYDEAIRS
Protein: von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2) (Q5GFL6)
Organism: Homo sapiens (Human)
Subcellular location: Secreted.
Interaction partners:
Sequence:
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLTHPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGEAKQPVNLCKPSPCMNEGSCVLQNGSYRCKCRDGWEGPHCENRFLRRP
Protein: P2X purinoceptor (P2X purinoceptor 5) (K7EQ78)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000681}.
Interaction partners:
Sequence:
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSNNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRLRTPSASPLHQE
Protein: Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c (Testis tissue sperm-binding protein Li 84P) (A0A024RC21)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE
Protein: Alpha/beta-Hydrolases superfamily protein (Lysophospholipase isolog, putative) (Putative lipase) (Putative lysophospholipase isolog) (Q9FVW6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 98A3
- F5F19.5 protein
- Flavone 3'-O-methyltransferase 1
- Shikimate O-hydroxycinnamoyltransferase
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- 4-coumarate--CoA ligase 4
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Trans-cinnamate 4-monooxygenase
- 4-coumarate--CoA ligase 1
Sequence:
MDRALTPRFDTPATLSPFRYRYGSSLAITRRFAPAIVCAKRSPIDGVSDELNLIASQNLDQAPARRLARSAFVDLQLQLDHCLFKKAPSGIRTEEWYERNSKGEDIFCKSWLPKSGDEIKAAVCFCHGYGSTCTFFFDGIAKQIAGFGYGVYAIDHPGFGLSDGLHGHIPSFDDLADNAIEQFTKMKGRSELRNLPRFLLGQSMGGAVALKIHLKEPQAWDGLILVAPMCKISEDVKPPPLVLKTLILMSTLFPKAKLFPKRDLSDFFFRDLSKRKLCEYDVICYDDQTRLKTAVELLNATRDIEMQVDKVSLPLLILHGDTDKVTDPTVSKFLHKHAVSQDKTLKLYPGGYHCILEGDTDENIFTVINDIVAWLDARVDPK
Protein: glutathione transferase (EC 2.5.1.18) (Q9LN39)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- L-galactono-1,4-lactone dehydrogenase, mitochondrial
- Glutathione synthetase, chloroplastic
- Glutathione hydrolase 2
- Putative inactive glutathione hydrolase 4
- Glutathione hydrolase 1
- Glutathione hydrolase 3
- Monodehydroascorbate reductase 4, peroxisomal
- Monodehydroascorbate reductase, chloroplastic/mitochondrial
- Monodehydroascorbate reductase 1, peroxisomal
- Glutathione reductase, cytosolic
Sequence:
MLVVQICSSPSHEMFWDISPQGKVPVLKIDDKWVTDSDATVGILEEKYPDPPLKTPAEFASVGSNIFEALENHLKSHDGPFIAGERVSAVDLSLAPKLYHLQVALGHFKSWSVPESFPHVHNYMKTLFSLDSFEKTKTEEKCVISGWAPKVNP
Protein: Zn-dependent exopeptidases superfamily protein (F4K1I4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEQIHSLVHRHPDKLSIELIKSGNKGYNAEVNVVTYCRGGKESDDRSNFRILLTFGQHGRELITSELAFRILSILSEEQFLPNKNGGILKNTLDKLVIKMVPIENPNGRKRVESGDLCERRNGRGVDLNRNWGVDWGKKEKDYDPSEENPGTAPFSEPETQIMRKLAISFDPHIWINVHSGMEALFMPYDHKNITPEGLPSQKMRTLLEKLNKFHCHDRCMIGSGGGSVGYLAHGTATDYIYDVVKAPMAFTFEIYGDNQTASRDCFKMFNPVDLPNFKRVLNDWSAAFFTIFQLGPLHLDGNTSKAADKWVSIDEYLDGYLVERKNRYGKNMEVIDVGMQEIKTYFRLFLLSSVLLMFMFCSRIAKSKYSRNSMPVLP
Protein: Capsid protein (Q68842)
Organism: Hepatitis C virus subtype 1b
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
Interaction partners:
Sequence:
NPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARQPEGESWAQPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFATFMGYIPLVMAPQGGARRALAH
Protein: Auxin-responsive protein IAA17 (Auxin response 3) (Indoleacetic acid-induced protein 17) (P93830)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin response factor 5
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 7
- Auxin transporter protein 1
- Protein AUXIN SIGNALING F-BOX 2
- Auxin response factor 19
- Auxin response factor 8
- Auxin response factor 18
- Auxin response factor 1
- NEDD8-activating enzyme E1 regulatory subunit AXR1
Sequence:
MMGSVELNLRETELCLGLPGGDTVAPVTGNKRGFSETVDLKLNLNNEPANKEGSTTHDVVTFDSKEKSACPKDPAKPPAKAQVVGWPPVRSYRKNVMVSCQKSSGGPEAAAFVKVSMDGAPYLRKIDLRMYKSYDELSNALSNMFSSFTMGKHGGEEGMIDFMNERKLMDLVNSWDYVPSYEDKDGDWMLVGDVPWPMFVDTCKRLRLMKGSDAIGLAPRAMEKCKSRA
Protein: Male sterile (3) 76Ba (Q9VVZ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform F
- Uncharacterized protein, isoform E
- Kekkon 6, isoform B
Sequence:
MPRPSMFDSDSDECEDLEFLNTRTIRDDKGNNRKRKSTDTIDKQDEFQEYNNHTSSSAFPIVKQLLCRRDPKPLPTKFRAGKVVMDFGPDEHADPMKVVYEDSPMKPPKTSRIAKTRRFPKEAITFPTKLQDVSRAPVYIELNLPMDSLWLFDRRFRPMSPISRSFVDDIDIDTPSPEDIWGSYLNVKMGIIKLSDAVWPLCCMTNSEVSKTPPPISTDSQNSNKFPTKTNKNIFETGWDRQIGENELRVLNQWLESEVLHNPHNDMEESDLKEKQRKGNEPQKPRILDNEEVSFANFTIEIEEQRAIKEWIKKEGLSEPHSDIDEYDMLFRLARDPEKNRDLLFDLLKPKDLIPQDKNVWKKFPPKLLELAQKPDFVEPEPWKSVLDEKIPIDNILEKEPEKETPFIENKPEKPVILEVKDIKPLPPKPEDEADIQGWLQQCSETISQQLQLLINEDSSSKTDSAEPEGIDFESEISKQQLKPRVLGESNKKVSPESGWQNSFTVRLEDFEDIVDQNMTEFRDPQAKRIRSKWNKRFGLKSAENLRRCVLLPPLPVHLDQCLQRIRILRRPNRRKVEQLRLRVEMNFCKTYCTLNMNRNLCLGIAVNNLSNAVYNRDIDVIQARYEASQIAWIWSDGSVLIINGRGHAMLAETQRDLLLRIAGKPNFKADPSNKLLHLRLISCAHFPWGISLPEFIESCAICPEPHMKYVYYVDKTIPGVVARVHETGMIQVFAMTTGEADNMLKKVYPITANHRRATIDVIKKEIVD
Protein: Probable cystine transporter YijE (P0ABT8)
Organism: Escherichia coli (strain K12)
Function: Involved in response to cystine. Overexpression confers tolerance to excess cystine.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Putative electron transfer flavoprotein subunit YgcQ
- Uncharacterized membrane protein YhdT
- Inner membrane protein YihN
- DNA utilization protein HofM
Sequence:
MSAAGKSNPLAISGLVVLTLIWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPTPFKYTLAIALLQTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAALFLGERLRRGQYFAILIAAFGLFLVLQPWQLDFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDLLSLTSWQMLYAALVMSVVALLVPQREIDWQPTVFWALAYSAILATALAWSLWLFVLKNLPASIASLSTLAVPVCGVLFSWWLLGENPGAVEGSGIVLIVLALALVSRKKKEAVSVKRI
Protein: Probable diacyglycerol O-acyltransferase Tgs4 (TGS4) (EC 2.3.1.20) (Probable triacylglycerol synthase tgs4) (P9WKC3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Interaction partners:
- Long-chain-fatty-acid--CoA ligase FadD13
- Putative FAD-containing monooxygenase MymA
- Putative diacyglycerol O-acyltransferase Rv3087
- Putative alcohol dehydrogenase D
- Putative oxidoreductase SadH
- Putative acetyl-hydrolase LipR
- Triacylglycerol lipase
- Diacylglycerol kinase
- Possible triacylglycerol synthase
- Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1
Sequence:
MTRINPIDLSFLLLERANRPNHMAAYTIFEKPKGQKSSFGPRLFDAYRHSQAAKPFNHKLKWLGTDVAAWETVEPDMGYHIRHLALPAPGSMQQFHETVSFLNTGLLDRGHPMWECYIIDGIERGRIAILLKVHHALIDGEGGLRAMRNFLSDSPDDTTLAGPWMSAQGADRPRRTPATVSRRAQLQGQLQGMIKGLTKLPSGLFGVSADAADLGAQALSLKARKASLPFTARRTLFNNTAKSAARAYGNVELPLADVKALAKATGTSVNDVVMTVIDDALHHYLAEHQASTDRPLVAFMPMSLREKSGEGGGNRVSAELVPMGAPKASPVERLKEINAATTRAKDKGRGMQTTSRQAYALLLLGSLTVADALPLLGKLPSANVVISNMKGPTEQLYLAGAPLVAFSGLPIVPPGAGLNVTFASINTALCIAIGAAPEAVHEPSRLAELMQRAFTELQTEAGTTSPTTSKSRTP
Protein: Synaptotagmin-2 (Synaptotagmin II) (SytII) (Q8N9I0)
Organism: Homo sapiens (Human)
Function: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101}.
Interaction partners:
- Stonin-2
- Vesicle-associated membrane protein 2
- Syntaxin-1A
- Otoferlin
- Synaptosomal-associated protein 25
- Synaptotagmin-1
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 8
- Synapsin-1
- Synaptic vesicle glycoprotein 2A
Sequence:
MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK