wanglab/gogpt-training-data huggingface dataset:
Protein: AMP deaminase (EC 3.5.4.6) (Q38E23)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Inosine-5'-monophosphate dehydrogenase
- Inosine-5'-monophosphate dehydrogenase
- Adenylosuccinate lyase
- Adenylosuccinate synthetase
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Adenosine kinase
- Adenosine kinase
- Hypoxanthine phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
Sequence:
MSVSLAPGRSSFFLRPWQSVNQFGQSPQPHPTATTEGRNDYVKCQLQESNMFKVVIDGDDGGVDLRKVYKRLDLAIDMRTQYKKSNEVSHLSANLKHVSISQEDGVYRASCRDVSIVCSQPWKKFVKDVQQLKLTVGNTTCIKACSHRLNIIQERSRMFFLLNADIEERHSFSKAGGVFSNVTKVDNCVLLSRFPDGQELLDFIQDWYRHTPDAPIRLRDGSNSTLRELFQANGVEDPTRLTVEGLGWQLYHGNYDKDDRKRDNKPLSAELRYSFLHLRGSCTARFLQRRMQREEQRTYNVQATEYSIPVYATYPGELFDIAEALHGQNIGPYKNNMWILELRLKHEVPSGVNYAVECKTIQDQLDNLFLPLFKATLQPSTQKYSSLVWLLKQLGGFQVEAVSTGVEADLDVESPVPSDINYEDKPNGLYYVYYIYANMKVLNDLRKMRGLNTFQLRISGTHQNCVNALLAGYLLGDVITRATRIMDYPVLQYLCGLHGVGLTVSPLHDHVRGVTPYQKHPLPNFLHRCLKVAISTHAPLYFHHSMTPLIEEYGTAMNLFRLSFLDVTELARNSVIMSSFPSERKKEWLGQRYHRGVDGNEFEKSQVTNVRLAFREESWELEHSLLRDLRLNQLSPQEVAGPSRWYYLSRVKEVEYDTVLDMRIRFPRTVLSGPLKEVKSAVAAAPHVARALDLRFKYIWEPPNPWETTSERTVEADFRRKTDSFNEDDWTYAASDAVFISFPKNVVHAWPRHVPTLEAFNSDLAELHGICSRPEVKDFAHQRLENLEHKFRLHLALNHANEAGTTEERTSSNRDIYQAVKVDTHIHMAAGMTGRQLLNFVVKKLVYSGDDIAFKKGDTILTLAQFFKNNGITPNLTVDQLNVQADHTLFERFDNFNNKYNPLESPDMRSLLLKTDNFMKGRYFAELIHDVFAQYSRDRHTYAENRVSIYGTNVKEWDSLALWFSTHGMSSQHNKWIIQVPRVYKVFRAQNIIGSFGQYLQNIFQPLWEASLHPSQHPLVHNFLNHVSGFDSVDNEATIDTPFTVVSPWAWTSVENPSYDYYLYYLYANIRTLNEFRASRGFSTFALRPHCGESGSVGHLYGAFLCANSICHGINLRKDPPMQYLYYLSRIGLHVSPLSNNALFLRFLNNPFPEFFRRGLNVSLSTDDPMMFHQTQEPLIEEYSVAARVWGLSPNDLCEIARNSVLQCGFDYTFKREAIGDCWYMSSSLGNDPLRTHLSDIRVAFRFETYHTEMQMLELCSGRPIKRCMLTTHQEEEINEMNVGIDADEVILSTHDQAMEMLLRDIESTRESLRVKRLDADALRRQQRHLVENLVEVGARRQSAMEAVERENRAKSLRYPRGVPPVPDTEFMTAERETVKRLLRWRPMPPGVLRHVRVEDVPKKGGRELPSLPPLHR
Protein: AvaB protein (C8V1V7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- Probable vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting protein
- Vacuolar sorting protein
- Pep3/Vps18/deep orange beta-propeller domain-containing protein
- Vacuolar assembly protein, putative
- Ypt/Rab-type GTPase avaA
- TGF beta receptor associated protein 1, putative
- CCZ1/INTU/HSP4 first Longin domain-containing protein
- Synaptobrevin homolog YKT6
- Vesicle transport v-SNARE protein vti1
Sequence:
MLSAFTARPLVELKPRDKSRIEAVLAYGDRVLVGLNNGNLRVYRVNEVEIEAEHDADPPPTQNNGNGHDAGYGGSRPPTQNGNGDNGTNNPVAKAKRTDLLRELEKFSRYKIEQLAIIKEAKLLVSLSGGYVSIHDLQTYELQEQLTRTKGAVAFAVTSNIVNDPETGVPSIVSRLAVAVKRKIMLWSWRDMELENDTAELTLVSGIKTLTWVSGTRLVAGLSSNFVLVDIEMKTVTDLVGPGSIGGLGGQETGRLAGVGVASMSYIGIGGSAPKPLATRLSEGQILLAKDINTQFTDIDGNSLGRRQIPWSSAPADIGYSYPFLLALHDSMKGILEVRNPETLSLLQSISLPSASTMHIAQPTISLAHAGKGFLVASDRIIWRMEALGYDSQIDSLVEKGYLDEAISLAGMLEDALLKNKEGRIREIKLEKAEGMFRLRRYLESMELFTEVSAPPETVIQLYPRIIAGDLTSISEEDELEGSMTESQSKLPDSQAQAEGNGSEETTPIKALNHTPSMMSFLRSRDEGSGSDSGSVRGKPEEARLEKPLTGKDLKLAVRELQAYLADVRRRFQRFLNPDGSLKIDPQTHAAKDEYTDSVMKLLDVGEDDEDYDLGEKLREKARLVDTTLFRVYMYATPSLAGSLFRIANFCDPEVVMEKLEETGRHNDLIDFLYGKKMHRQALELLRKFGQSESEEETAPQLHGPKRMVAYLQHLPPEHIDLILEFSEWPIREDPDLGMEIFLADTENAETLPRQKVLDFLQGIDDKLAVRYLEHVIGELNDLTPDLHQRLAVLYLNRLQKHQNSKDGFATEDEYKFWREKLITMLKTSDQYSPSKILARLDRDDPEFFEARAILFSKMGQHRQALEIYVFKLEDYVKAEEYCNHLHRTEDTPTPSGPAAEYSALAPSDDEPSIYHTLLSLYLTPPHGYKPQYAPALDILARHGSRLPANSALDLIPESLPVHELEFYFKGRMRAANTILNESRITANLLKVQTIKTRAELLVGEGTDGRSSRSRHVTITEERVCSVCHKRIGGSVINVFPEAGLSFLIPRIVRLPKDSLFLLLRTPFTGLVYLLPCSSRRLMHRHQPLPLRSSLPPWLHSLTIGGPGLQLFSCPPPYVRSKTN
Protein: Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) (Q92896)
Organism: Homo sapiens (Human)
Function: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:2355176}; Single-pass type I membrane protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:Q62638}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q62638}. Note=Golgi medial cisternae. Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:Q62638}.
Interaction partners:
- E-selectin
- P-selectin
- P-selectin glycoprotein ligand 1
- Junctional adhesion molecule A
- Fibroblast growth factor 2
- Vascular cell adhesion protein 1
Sequence:
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQPPFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLVVECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR
Protein: Mediator of RNA polymerase II transcription subunit 7 (D4A7V2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364060}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 9
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 27
Sequence:
MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDTDDNSNCTGQNEQQRESSGHRRDQIIEKDAALCVLIDEMNERP
Protein: Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) (Q72D36)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
Interaction partners:
- Argininosuccinate synthase
- Ornithine carbamoyltransferase
- Acetyltransferase, GNAT family
- N-acetyl-gamma-glutamyl-phosphate reductase
- Acetylglutamate kinase
- Acetylornithine aminotransferase
- Arginine biosynthesis bifunctional protein ArgJ
- Adenylosuccinate lyase
- Aspartate ammonia-lyase
- Aspartate ammonia-lyase, putative
Sequence:
MAEKKMWGGRFKQGTATLVEEYTESVSYDRALYAQDIAGSMAHARMLARQGVLTAEEAAIIVDGLATVRSEIEAGSFVWRREFEDVHMNIENRLTELVGDVGKKLHTGRSRNDQVALDFRLFVSDRVRVWRELGRDLVGVIVDQARQHTATLLPGCTHMQPAQPVSLAQHLLAYAWMLRRDIDRLEDCDKRARVCPLGAAALAGTTYPLDPASVADELGMYGTFRNSMDAVSDRDFVLEALFDGSVIMAHLSRLCEEFILWANPAFGYIFLPDAYATGSSIMPQKKNPDVAELMRGKTGRVYGALTTMLTTVKGLPMTYNRDLQEDKEPFIDADRTVSASLEIMAGMLREVRFNTARMRTALRSGFLNATELADYLVGKGIPFREAHHLTGAAVALAEEKGVTLEELPLEDYRGICDRIDEDVYPILEPEAAVSRRETPGGTGPRSVAAQIAELDSWLGR
Protein: Mannan endo-1,4-beta-mannosidase B (EC 3.2.1.78) (Beta-mannanase 5B) (Man5B) (Endo-beta-1,4-mannanase B) (Q5B833)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Endo-1,4-mannanase that catalyzes the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans and heteromannans. It is a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Active against locust bean gum and gum guar. Also has efficient transglycosylation activity. Produces mainly mannopentaose and mannoheptaose out of mannotetraose. May even prefer sugars as acceptors instead of water.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q99036}.
Interaction partners:
Sequence:
MRLIHAVLGLLAGAAPALVAASPAAPIGNGRDQVSKAVGRHFEIDGKVQYFAGTNCWWLGNLLNDFEVELAVSQIAETGYKVVRTWGFFGVNDPSNPGQPVYYQVLNESLYEGGLGINYGSNGIRRLDTVVSLAERYDIQLVLTFMNNWNDFGGINIYSNAFGSNATTWYTDKKSQRAYREYIKFIVNRYKGSSAIFAWELGNEPRCKGCDPSVIYNWAKSVSAYIKKLDKKHMVALGDEGWLCPPEGDGTYAYDCSEGVDFVKNLEIETLDYGTFHLYPESWGYNYSWGSEWVLQHDAIGKRFNKPVVFEEYGTPLNHTQLERPWQLTTVKETQVAADFIWQFGTVLPVEGTEWGDVNSIYYGTEEYEVLAVQHAWEMARKKVPRH
Protein: Nitrogen permease reactivator protein (EC 2.7.11.1) (Serine/threonine-protein kinase NPR1) (P22211)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression. Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane. Contributes also to the stability and the retention of GAP1 at the plasma membrane. Inversely, promotes the degradation of tryptophan permease TAT2 under the same conditions. Activity is regulated by the TOR signaling pathway via phosphatase SIT4. Although thought to be involved in regulation of GLN3-dependent transcription by nitrogen catabolite repression, this seems to be an indirect effect from the reduced uptake of the nitrogen-repressing compound.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11500493}. Note=Appears to be more concentrated in punctate structures reminiscent of the Golgi or of an endosomal compartment.
Interaction partners:
- Ubiquitin ligase-binding protein BUL1
- E3 ubiquitin-protein ligase RSP5
- Ubiquitin ligase-binding protein BUL2
- General amino-acid permease GAP1
- Protein PAR32
- Serine/threonine-protein kinase TOR2
- Serine/threonine-protein kinase SCH9
- Nitrogen regulatory protein GLN3
- Ammonium transporter MEP1
- Putative mitochondrial carrier protein PET8
Sequence:
MSSLTRLLQEKRKNETSNSSPRTSADTLTTTPESQSLDLHSRNKSSSHIGSVSNSSSSDRNRANVPVPGSVTTVTQIYSEEDSSSTAGSSLDDRNQFSSSFLNANFAHTASFYGTSAQSRDRFGSLINDQGTAGLSSHGGSFAAQNRITSRLSTTSHTSGRAIPSLSSSIPYSVPNSNKDNNSSNSNSSSLSSSWLETYAGGMPNNISAIDSNVISSPKVDSVEPRFVISKQKLQKASMDSNNANATQSRSISRSGSFSSQLGNFFFSKNSKESSNSNSAGMSFSANSNGPSPNIKNPNVTNGSTPIPKPIRARQSSIYSASRQPTGSYTDNFYGSPSSVHDHLPPSQSVPRSQHSSIGDLKRFFKKSSNSNLSSNSNNVIPNGSPLSSGIAVPSHSHSSSHFAAGNNSYSTSYNGNGDTIYSHSHGGSGIPFSKRYIKTGADLGAGAGGSVKLAQRISDNKIFAVKEFRTKFENESKRDYVKKITSEYCIGTTLNHPNIIETIEIVYENDRILQVMEYCEYDLFAIVMSNKMSYEEICCCFKQILTGVQYLHSIGLAHRDLKLDNCVINEKGIVKLIDFGAAVVFSYPFSKNLVEASGIVGSDPYLAPEVCIFAKYDPRPVDIWSSAIIFACMILKKFPWKIPKLRDNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHSTEKKKPESSSNNVSDPNNVNIGPQRLLHSLPEETQHIVGRMIDLAPACRGNIEEIMEDPWIRSIDMCHLVEDGLSFKVVRGEDHHHTQVDQSEAHIAGLEKKKKKQNNQ
Protein: Meiotically up-regulated gene 153 protein (Q9C0U3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Dual specificity phosphatase ibp1
- Sodium/potassium exporting P-type ATPase cta3
Sequence:
MGSPSLTKTINASLSLHSITQPITLLKTMHYVLQLTILPSAMQHYATLRNFTHPACSVNKQAEQGKEQQQYAMKSQFQFRSGICSKVRSDELGFKGNSLQLNDLPKNPY
Protein: Smoothelin (Q921U8)
Organism: Mus musculus (Mouse)
Function: Structural protein of the cytoskeleton.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Exhibits a filamentous organization. {ECO:0000250}.
Interaction partners:
- Myosin-11
- Transgelin
- Calponin-1
- Actin, aortic smooth muscle
- Myocardin
- Caldesmon 1
Sequence:
MADEALAGLDEGALRKLLEVTADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQDNKENWLHSQQREAEQQAALARLAGRLESMNDVEELTTLLRSAGEYEERKLIRAAIRRVRAQEIKAATLAGRLCSRLPSSGPREDSRRQAAHTLDPGKVPEPEQQEQQTEVLEPTPTPEDTSQDVTTVTLLLRAPPGGRPSSPASPHNSPTSASPEPLLEPAGAQCPAVEAPVSSEPLPHPSEAPSPEPPMSPVPSSSRGRVISKPLPGPTEPSDTLDSIRGFSNTKRADPSETKSCQRSLSVLSPRQPTPNREPTSLAGPSQFRRVGSVRDRVQKFTSDSPVVARLQDGPPRTALASPTPTRLPGPSLISTTPASSSSSNSSSPSPSDTSSHKKQRELAHSLAELQSCPQEEGPGGRGLALRSLENRAGGPKPCSEEPSTPPPVAVGTGEPGGSMKTTFTIEIKDGRGQASTGRVLLPTGNQRAELTLGLRAPPTLLSTSSGGKNTITHISNPGTVTRLGSVTHVTTFSHASPGNRGGCNFKMEPDPAEPPSTTVEAANGAEQARVDKGPEGRSPLSAEELTAIEDEGVLDKMLDQTTNFEERKLIRAALRELRQRKRDQRDKERERRLREARARPGESRSNVATETTTRHSQRAADGSTVGTVTKTERLVHSNDGTQTARTTTVESSFMRRLENGSSSSSTTTTTVQTKSFSSSSSSSSSKKMGSIFDREDQTSSRPGSLAALERRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGSAGGPGTPRTAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEMAFSSAEMLVDCVPLVEVEDMMIMGKKPDPKCVFTYVQSLYNHLRRHELRLRGKNV
Protein: Cell division control protein 42 homolog (EC 3.6.5.2) (Q6PFU4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Midbody {ECO:0000256|ARBA:ARBA00004214}.
Interaction partners:
- IQ motif-containing GTPase-activating protein 1.
- WASP actin nucleation-promoting factor b.
- Actin nucleation-promoting factor WAS
- Par-6 family cell polarity regulator gamma b
- Par-3 family cell polarity regulator alpha, b.
- Par-6 family cell polarity regulator alpha.
- Par-6 partitioning defective 6 homolog beta
- Non-specific serine/threonine protein kinase.
- WASP-like actin nucleation-promoting factor b.
- Par-6 family cell polarity regulator gamma a.
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKKRKCVLL
Protein: Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) (Q92481)
Organism: Homo sapiens (Human)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61313}. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. {ECO:0000250|UniProtKB:Q61313}.
Interaction partners:
- Transcription factor AP-2-alpha
- BTB/POZ domain-containing protein KCTD1
- YEATS domain-containing protein 4
- Cbp/p300-interacting transactivator 2
- BTB/POZ domain-containing protein KCTD15
- Transcription factor AP-2-delta
- Mast/stem cell growth factor receptor Kit
Sequence:
MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHRK
Protein: Auxin response factor 6 (Q9ZTX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Regulates both stamen and gynoecium maturation. Promotes jasmonic acid production. Partially redundant with ARF8.
Subcellular location: Nucleus.
Interaction partners:
- Protein BRASSINAZOLE-RESISTANT 1
- Transcription factor PIF4
- Auxin transporter protein 1
- Auxin-responsive protein IAA9
- Auxin-responsive protein IAA8
- DELLA protein RGA
- Auxin-responsive protein IAA28
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA3
- Auxin-responsive protein IAA7
Sequence:
MRLSSAGFNPQPHEVTGEKRVLNSELWHACAGPLVSLPPVGSRVVYFPQGHSEQVAASTNKEVDAHIPNYPSLHPQLICQLHNVTMHADVETDEVYAQMTLQPLNAQEQKDPYLPAELGVPSRQPTNYFCKTLTASDTSTHGGFSVPRRAAEKVFPPLDYSQQPPAQELMARDLHDNEWKFRHIFRGQPKRHLLTTGWSVFVSAKRLVAGDSVLFIWNDKNQLLLGIRRANRPQTVMPSSVLSSDSMHLGLLAAAAHAAATNSRFTIFYNPRASPSEFVIPLAKYVKAVYHTRVSVGMRFRMLFETEESSVRRYMGTITGICDLDPTRWANSHWRSVKVGWDESTAGERQPRVSLWEIEPLTTFPMYPSPFPLRLKRPWPPGLPSFHGLKEDDMGMSMSSPLMWDRGLQSLNFQGMGVNPWMQPRLDTSGLLGMQNDVYQAMAAAALQDMRGIDPAKAAASLLQFQNSPGFSMQSPSLVQPQMLQQQLSQQQQQLSQQQQQQQQLSQQQQQQLSQQQQQQLSQQQQQQLSQQQQQQAYLGVPETHQPQSQAQSQSNNHLSQQQQQVVDNHNPSASSAAVVSAMSQFGSASQPNTSPLQSMTSLCHQQSFSDTNGGNNPISPLHTLLSNFSQDESSQLLHLTRTNSAMTSSGWPSKRPAVDSSFQHSGAGNNNTQSVLEQLGQSHTSNVPPNAVSLPPFPGGRECSIEQEGSASDPHSHLLFGVNIDSSSLLMPNGMSNLRSIGIEGGDSTTLPFTSSNFNNDFSGNLAMTTPSSCIDESGFLQSSENLGSENPQSNTFVKVYKSGSFGRSLDISKFSSYHELRSELARMFGLEGQLEDPVRSGWQLVFVDRENDVLLLGDDPWPEFVSSVWCIKILSPQEVQQMGKRGLELLNSAPSSNNVDKLPSNGNCDDFGNRSDPRNLGNGIASVGGSFNY
Protein: GH10149p (Q86P91)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
Sequence:
LIEFSADLDQSFQSPRNREQTARMTSRNLTEVFVIMRNNASKNRNHYDDRRGSDAERLLKHSVREAEEGLELQDDYGTPPAWLDKFEEAQYTMSKIKPKLDELGSLHARHLLRPAFDDQRDDECDIEVLSQIVSKLITSTHRHIQCVRSSIGVGSKMEQCLTVNAVHCALLQLQELTVKFRASQNAYLLQLNSREERSQKYFDDGGGAGAGDVFTNVELGEQSAENFVDSFDNFLQPPAEGKSGNGYLFEDDEQAIDDHFQRPPASRMTQQQLLLFEEENTRVAQHREQEVTKIVKSIYDLNDIFKDLGHMVQEQGTVLDRIDYNVEQTQTRVSEGLRQLHKAEMYQRKNRKMCVILVLAAVTFFMLLLLILTKL
Protein: argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) (Q6FWJ8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Argininosuccinate lyase
- ornithine carbamoyltransferase
- Carbamoyl phosphate synthase arginine-specific large chain
- Protein ARG5,6
- Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase
- Adenylosuccinate synthetase
- Carbamoyl phosphate synthase arginine-specific small chain
- Arginine biosynthesis bifunctional protein ArgJ
- asparagine synthase
- Aspartokinase
Sequence:
MSKGKVCLAYSGGLDTSIILAWLLEQGYEVVAFMADVGQEEDFEAARAKALKIGATKVVISDVREQFVKDIIFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAEQEGCFAVSHGCTGKGNDQIRFELSFYALKPDVQVIAPWRLPEFFNRFAGRKDLLDYAAEKGIPVAQTKAKPWSTDENMAHISYEAGILEDPNTTPPKDMWKLITDPMDAPNTPQDITLDFEKGIPVKLTYKDNATGKEHVVTDALELALHVSNLGRANGVGRIDIVENRYINLKSRGCYEQALLTILRKAHVDLEGLVLDKEVRQLRDQFVTTTYSKLLYNGSYFTPECEFIRAMIEPSQKTVNGTVRLSLYKGNVIVLGRYSNTESLYDATESSMDELTGFLPTDTTGFIAIQAIRVKKFGEAKKASGEKITL
Protein: Transducin/WD40 repeat-like superfamily protein (F4JN30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- TRM32-like protein
- Alpha/beta-Hydrolases superfamily protein
- Heavy metal transport/detoxification superfamily protein
- Alba DNA/RNA-binding protein
- Chromatin remodeling 34
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Transcription factor DUO1
- Heavy metal-associated isoprenylated plant protein 17
- Sugar transport protein 8
- 14-3-3-like protein GF14 omicron
Sequence:
MFVKKLVEIAAKKPGGSSSEGLRANDVEPRIALHYGIPSGSHLFAYDPFQKILAVSTKDGRIKLFGKDQTQALLVSEETSTSRFLEFVQNQGILLNVNSKNQIEVWDLDKKLLSHVHVFNGEITSFRVMQHTPYFYVGDSSGNVSVFKIEQDSNQVIQLEYTIPYLASNGSPIEASEDTSVVSILPQLTAESKRILLVFSSGFIALWDIKESKPILKTGVHGMVKQDTKKATCACWVCPSGSRVSVGYSNGDILIWSIPSKGECSPESSAMICKLNLGYKSEKIPIASLKWVYAEGKASRVYVIGSSSNSLQVVLLNEQTETRMIKLGLHVSEPCADMEMIIADVNEQSKHKQDFLFVLGKSGRVYAYDDYMIEKYLIQSQSKSSPSLPKETVVKLPFSDSSSITVGKFLTNPSHLLNLSDEDYAQLAKDAVPFLPFHTVPKESSRSAHFPGFTKVKNVYITGHCDGTISVWDMTCSFPILVLFLKEQQIDQDVSSRGNAALTALHYDSNSRLLVSGDHNGMVRLYRFKPEPYLTENSFIPFQGSLKKGNNHIVQSVKYIKLTGSITCIQKSQNSKHLAIGSDQGHVSLVDIEEANVLYTKHIASDICPGIISLQFESCIVQGFEKNVLVVAMRDSSVFALDSDTGNMIGTNMIKPKKPFKVLYMQILDGKQDTSGNGFDTSRESTVEEISIRQPSVLVCSEKAIYIYSLAHVVQGVKKVLHKKKFSSSPICSASTFYGTSGVGLTLVFTDGTVEIRSLPELSQLKQTSIRGFTYSSPKPNSLPEITISASWDGDLVMVNGDDELIVSSVLPQKETFRLVESMNRVYKKDNSVCHEGIITSSSPREKKSMFGSVFKTKSKRTTDTEPESSKETIEELSKIFSTANFPWNNNVENSREINTITRVEDEEELDIDDIDIDDHHPNQQQQEKPKEQGILSGLSKQKMANRFSNFKGKLKQMAAKNEKSVVTNDEKHEEKNGATVDQIKKKYGFTSSDEMGAAKMAQSKLQDNLKKLQGISLRTTEMEDTAKSFSSTAKELLNAVEFNKQSSKS
Protein: Flagellar M-ring protein (P23447)
Organism: Bacillus subtilis (strain 168)
Function: The M ring may be actively involved in energy transduction.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Bacterial flagellum basal body {ECO:0000250}.
Interaction partners:
- Flagellar biosynthetic protein FliQ
- Probable flagellar assembly protein FliH
- Flagellar biosynthetic protein FliP
- FlaA locus uncharacterized protein YlxG
- Flagellar basal-body rod protein FlgG
- Flagellar biosynthesis protein FlhA
- Probable flagellar hook-length control protein
- Flagellar basal-body rod protein FlgC
- Flagellar hook-basal body complex protein FliE
- Flagellar basal body rod protein FlgB
Sequence:
MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVFASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAEGLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLPKDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNSTYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDFTKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGENTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQDDIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPLWAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAESVRRKQLEKMAKDKPEDFAKLLRSWLAED
Protein: Ig-like domain-containing protein (Q8BLX5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLLLDAWTHIPHCVLLLILLLGLKGAAVRELKVIQPVKSFFVGAGGSATLNCTVTYLLPVGPIKWYRGVGQSRLLIYPFTGEYFPRITSVSDVKKRSNLDFSIRISNVTPADSGTYYCVKFQRGSSEPDIEIQSGGGTELSVFAKPSSPMVSGPAARAVPQQTVTFTCRSHGFFPQNLTLKWFKNGNEISHLETSVEPEETSVSYRVSSTVQVVLEPRDVRSQIICEVDHVTLDRAPLRGIAHISEIIQVPPTLEISQQPTMVWNVINVTCQIQKFYPRRFQVTWLENGNISRREVPFTHIVNKDGTYNWISWLLVNISALEENMVVTCQVEHDGQAEVIETHTVVVTEHQRVKGTSTMSGKVFTPPLCLNVNWTSFFM
Protein: Serine palmitoyltransferase-regulating protein TSC3 (Temperature-sensitive CSG2-mutant suppressor protein 3) (Q3E790)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stimulates the activity of serine palmitoyltransferase (SPT).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10713067, ECO:0000269|PubMed:14562095}; Single-pass membrane protein {ECO:0000269|PubMed:10713067, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase 2
- Protein ORM1
- Phosphatidylinositol-3-phosphatase SAC1
- Protein ORM2
- 3-ketodihydrosphingosine reductase TSC10
- Ceramide synthase subunit LIP1
- Ceramide synthase LAC1
- Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2
- Palmitoyltransferase ERF2
Sequence:
MTQHKSSMVYIPTTKEAKRRNGKSEGILNTIEEVVEKLYWTYYIHLPFYLMASFDSFFLHVFFLTIFSLSFFGILKYCFL