wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q38DT7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHRCALLTSSIYSTVRCEVVAATTINSAVASQRRFQGRIPNKGYRAQPPVPDRLKDAMTLFGADAHNVTPDDPPYVPEEQRMHMTKEIMVSNQFMRNHAKLDRLRAALDTVHNEGPDHEGWQEVYLFLRTTEMCCELQKDATDVFPKGKKLWINLDECEEKRLPVLMEMPNGMLVLPVFSMEEYLDHYFGRVDAFESCWFPVPRMGTRYEEFCKLPFPVTAVGSIHHLSALATIALSSSQFGILVNPGQRTSKFLTYPEMVELAKQKRLRPKDRNTDLKRKSGDVVEDLYDRTLRCGFDTRKLVMRRVEPAEAAKLLLRRPKIPQVAQLELHLLLCDYETIINVFVRTTDRPQWRRVLGASEKLTQIDVVIEGGKPNREIFERIKKWSFMDEFHSDVHIEFAAAPPTAREGDGMMVVYDGADGKLLRSMKSFKGVTLRKALGYDEPLLDSHGRPVSFT
Protein: Tail tube protein gp17.1* (TTP) (Gene product 17.1) (gp17.1) (Major tail protein) (MTP) (O48449)
Organism: Bacillus phage SPP1 (Bacteriophage SPP1)
Function: Forms the 160 nm long, sixfold helical, rigid tail tube. Binding to the entry receptor triggers structural rearrangements of the tail tube leading to ejection of the phage DNA into the host.
Subcellular location: Virion {ECO:0000269|PubMed:17611601}.
Interaction partners:
Sequence:
MPETPIMGQDVKYLFQSIDAATGSAPLFPAYQTDGSVSGERELFDEQTKNGRILGPGSVADSGEVTYYGKRGDAGQKAIEDAYQNGKQIKFWRVDTVKNENDKYDAQFGFAYIESREYSDGVEGAVEISISLQVIGELKNGEIDTLPEEIVNVSKGGYDFQQPGQTTGEAPGTVPLPNAPQNLTYTATTDSVTVKWDAVEGADSYNVYRGAEKKLDANVTTTSHTLTGIQPDTQLTVNVAAVNAGGESPMSQIVTKTLPAESTG
Protein: 60S ribosomal protein L24, putative (Q38B56)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal protein L7a
- 60S ribosomal protein L27, putative
- 60S ribosomal subunit protein L31, putative
- Ribosomal protein
- 60S ribosomal protein L35A, putative
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L27a
- 60S ribosomal protein L19, putative
Sequence:
MRTIDCEFSHFAVHPGHGRRYVPFAFLSTKPVLTFARPKCFAMYMRKKNPRFIAWTRTYRRIHRKTTTDRVGRRRAARTVRAERAIVGAELSYIQEVRAKAKKVDRTAKGKAVREEMAARKAAKK
Protein: Ascorbate transporter, chloroplastic (Phosphate transporter PHT4;4) (AtPHT4;4) (Probable anion transporter 2) (Q8GX78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inorganic phosphate and probable anion transporter. Ascorbate transporter bridging the chloroplast envelope. Transports ascorbate from the cytosol into the chloroplast. Requires chloride ions and the presence of an electrochemical potential across the membrane for activity.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:14564522, ECO:0000269|PubMed:18353780, ECO:0000269|PubMed:25557369}; Multi-pass membrane protein {ECO:0000269|PubMed:14564522, ECO:0000269|PubMed:18353780}.
Interaction partners:
- Inorganic phosphate transporter 1-4
- Inorganic phosphate transporter 2-1, chloroplastic
- Sodium/pyruvate cotransporter BASS2, chloroplastic
- Putative defensin-like protein 288
- F-box/FBD/LRR-repeat protein At1g13570
- Defensin-like protein 268
- Alpha/beta-Hydrolases superfamily protein
- Nucleotide-sugar transporter family protein
- Probable sodium/metabolite cotransporter BASS4, chloroplastic
- ATG8-interacting protein 2
Sequence:
MALGGLISNRNFGSFIGSGNGCQRLGKSGAEVSKLFPNALLCRNHQPLQASLHHESGHMRRSFGCFLQPRMDSVIRFRNSIKINRSRAYYKSEESDITEGVVPSADGSAEAILVEGNLQNASPWWQQFPRRWVIVLLCFSSFLLCNMDRVNMSIAILPMSQEYNWSSATVGLIQSSFFWGYLLTQILGGIWADKFGGKVVLGFGVVWWSFATIMTPIAARLGLPFLLVVRAFMGIGEGVAMPAMNNMLSKWIPVSERSRSLALVYSGMYLGSVTGLAFSPMLITKFGWPSVFYSFGSLGSIWFLLWLKFAYSSPKDDPDLSEEEKKVILGGSKPREPVTVIPWKLILSKPPVWALIISHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAVFANIGGWIADTLVSRGLSITNVRKIMQSIGFLGPAFFLSQLSHVKTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQRGSWDDVFKVAVALYLIGTLVWNLFATGEKILD
Protein: Uncharacterized protein (Q2F987)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MRLLLPFERGRPLLQLSSDDSSPAVDSDLSQPKKRKEKANESEYNQSIAFDDSLTASSTQASISCSRHRRLPAPVHERWMKVSLTTNSRMLGTISFRAPVERPSSSLFLNLGERQKRSPERPRLFQGKEGDRMRDGVPAEWNGHPWGQLCKTEFTIKLDGKTTTKITRNPAQSEWRENPCALEGSEAVRTLIDK
Protein: Zgc:162603 protein (A4QP10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDPAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKLRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHILLKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELRDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRSLPLFPLTKPHINFMAAKL
Protein: Probable receptor-like protein kinase At5g59700 (EC 2.7.11.-) (Q9FN92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- AT3g15480/MJK13_14
- GPI-anchored protein LLG3
- Cyclase-associated protein 1
- Tetraspanin-3
Sequence:
MGGEKFGFLIWILSIPCLIFLCYGYVPVDNYLINCGSSTNVTVTSRVFISDNLASNFLTSPNEILAASNRNSNSDIYQTARIFTGISKYRFSVARGRHWIRLHFNPFQYQNFQMVSAKFSVSSETHVLLSDFTVSSRVMKEYSLNVATDHLELTFTPSGDSFAFLNALEVVSVPDTLFSGDPSFAGSPGKFQGLSWQALETVYRVNMGGPRVTPSNDTLSRIWEPDSEFLVEKNLVKSVSKIASVDYVPGFATEETAPRTVYGTCTEMNSADNPSSNFNVTWDFDVDPGFQYFLRFHFCDIVSKALNQLYFNLYVDSMDVVENLDLSSYLSNTLSGAYAMDFVTGSAKLTKRIRVSIGRSSVHTDYPTAILNGLEIMKMNNSKSQLSIGTFLPSGSSSTTKKNVGMIIGLTIGSLLALVVLGGFFVLYKKRGRDQDGNSKTWIPLSSNGTTSSSNGTTLASIASNSSYRIPLVAVKEATNSFDENRAIGVGGFGKVYKGELHDGTKVAVKRANPKSQQGLAEFRTEIEMLSQFRHRHLVSLIGYCDENNEMILVYEYMENGTLKSHLYGSGLLSLSWKQRLEICIGSARGLHYLHTGDAKPVIHRDVKSANILLDENLMAKVADFGLSKTGPEIDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMFEVLCARPVIDPTLTREMVNLAEWAMKWQKKGQLEHIIDPSLRGKIRPDSLRKFGETGEKCLADYGVDRPSMGDVLWNLEYALQLQEAVVDGDPEDSTNMIGELPLRFNDYNHGDTSVNFSVAKEGRFDEEESSVDDSSGVSMSKVFSQLIKSEGR
Protein: Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] (P02794)
Organism: Homo sapiens (Human)
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26436293}. Lysosome {ECO:0000269|PubMed:26436293}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24695223}.
Interaction partners:
- Nuclear receptor coactivator 4
- Ferritin light chain
- Transferrin receptor protein 1
- Ferroportin
- Natural resistance-associated macrophage protein 2
- Scavenger receptor class A member 5
- Cytochrome c oxidase subunit 8A, mitochondrial
- Mitogen-activated protein kinase kinase kinase 11
- Peptidyl-prolyl cis-trans isomerase FKBP2
- Fos-related antigen 1
Sequence:
MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES
Protein: Exosome complex component RRP40 (EC 3.1.13.-) (Exosome component 3) (Ribosomal RNA-processing protein 40) (Q7TQK4)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NQT5}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NQT5}. Nucleus {ECO:0000250|UniProtKB:Q9NQT5}.
Interaction partners:
- Exosome complex component CSL4
- Exosome complex component RRP4
- Exosome complex component MTR3
- Exosome complex component RRP43
- Exosome complex exonuclease RRP44
- Exosome complex component RRP45
- Exosome complex component RRP46
- Exosome complex component RRP41
- Exosome complex exonuclease RRP42
- Exosome complex component 10
Sequence:
MAEVLSAGPESVAGCRARAVHKVLNQVVLPGEELVLPDHEDVDGLGGAGEQPLRLNAGARPRLRVVCGPGLRRCGDRLLVTKCGRLRHKEPSGGGGGVYWVDSQQKRYVPVKGDHVIGIVIAKSGDIFKVDVGGSEPASLSYLAFEGATKRNRPNVQVGDLIYGQCVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIVQELGKLYPLEIVFGMNGRIWVKAKTIQQTLILANVLEACEHMTTEQRKQIFARLAES
Protein: Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Beta-mannanase) (CaMan) (Endo-beta-1,4-D-mannanase) (B4XC07)
Organism: Cryptopygus antarcticus (Antarctic springtail)
Function: Hydrolyzes 1,4-beta linked polysaccharide backbones of mannans. Has high activity toward locust bean gum. Also active toward konjac and beta-1,4-mannan. Hydrolyzes mannotetraose (M4) and mannopentaose (M5) to mannobiose (M2) and mannotriose (M3) with a little production of mannose (M1). Hydrolyzes beta-1,4-mannan to M2, M3 and M4. Hardly hydrolyzes M2 and M3. Does not hydrolyze p-nitrophenyl-beta-D-mannopyranoside, gua-gum, carboxymethyl cellulose, soluble starch or laminarin.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MVKLFSFLLLVWVASPAFSSEFLKASGSNFYYGGQKVFLSGVNFAWRSYGSDFGNGQYASNGPALKDWINKVKASGGNTARVWVHVEGQVSPAFDSHGFVTSTDSKKTLINDLSDLLDYANGQNVFLILVLFNGALQNNSNVQNLFWDESKLNSYINNALTPMVNALKSKPSLAAWEVLNEPEGTLQPGSDQNSCYDTSTLAAQGAGWGGKKFPMKQILKTINWISSAIHNADSKALVTVGSWSELTQTDSFGYRNHYKDSCLTGAGGKSNGIINFYQMHTYSHSGKWNQNAPFKVNRWAYNVNDKPLLIGEFASVCSQNEGIQNLYKYAYNNGYNGALTWQFNSGGDCSDTYSNQMYGMQALKGQNDQSGGKGGMVSVNIN
Protein: Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Q8N381)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDAAENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
Protein: Conserved protein (P96246)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- HTH-type transcriptional regulator RipA
Sequence:
MAMNLLHRRHCSSAGWEKAVANQLLPWALQHVELGPRTLEIGPGYGATLQALLGLTASLTAVEVDNSMVERLNRRYGQRARIIRGDGTQTGLPDDHFTSVVCFTMLHHVASAQLQDQLFAEAYRVLQPGGVFAGSDGVPSLPFRLIHIADTYTPIAPADLPGRLRAVGFTDIHVDVAGARLRWRATKPVAA
Protein: Transmembrane protein 161B (Q7SY10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival. Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm.
Subcellular location: Cell membrane {ECO:0000269|PubMed:33597309}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Inactive C-alpha-formylglycine-generating enzyme 2
- Matrix-remodelling-associated 7.
- All-trans retinoic acid-induced differentiation factor
Sequence:
MGVISVQLVVTMVMASVIQKIIPHYSFARWLLCSGSLRWYQHPTEDELRTLAGKQQKGGKSKKDRKYNGHLENKPMTIPKDIDLQLETKCIAEVDTLALHYFPEFQWLVDFTVAATVVYLITELYFCVAEPSGEMNISVVWSLLVLAFVMKILFSLTAHYFRLEEGGERSLCITFAFFFFVKAMAILIVTENYLEFGLETGFANFSESAVQFLENQGLESQGPISKLTFKLILALLCALIGAFLTFPGLRLAQMHLDALTLNNCKVTQTLLHINFLAPLIMVLLWVKPITKDYITNPTFGKDNVPLMSEKTYDTLRLWVILLLCVLRLAMMRHHLQAYLNLAQKGVLQMKKEAGRISTVDLQKMVARVFYYLCVIALQYIAPLVMLLHTTLLLKTLGGHSWVIYSDESLPCLSNEDSSPAEVGQSQMEASQTVAQLSVALGGLRTVFSPLLFRGLLSFFTWWIAACLFSTSLFGLFYHQYLMAA
Protein: Cytochrome c-552 (EC 1.7.2.2) (Cytochrome c nitrite reductase) (TvNiR) (L0DSL2)
Organism: Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 / ALEN2)
Function: Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process. Has very low activity toward hydroxylamine. Has even lower activity toward sulfite. Sulfite reductase activity is maximal at neutral pH.
Subcellular location: Periplasm.
Interaction partners:
- Periplasmic nitrate reductase
- Nitrite reductase [NAD
- Nitrite reductase [NAD
- Periplasmic nitrate reductase, electron transfer subunit
- nitrate reductase
- Glutamine synthetase
- Assimilatory nitrate reductase large subunit
- Glutamate dehydrogenase
- Glutamate dehydrogenase
- Respiratory nitrate reductase alpha chain
Sequence:
MNDLNRLGRVGRWIAGAACLFLASAAHAEPGENLKPVDAMQCFDCHTQIEDMHTVGKHATVNCVHCHDATEHVETASSRRMGERPVTRMDLEACATCHTAQFNSFVEVRHESHPRLEKATPTSRSPMFDKLIAGHGFAFEHAEPRSHAFMLVDHFVVDRAYGGRFQFKNWQKVTDGMGAVRGAWTVLTDADPESSDQRRFLSQTATAANPVCLNCKTQDHILDWAYMGDEHEAAKWSRTSEVVEFARDLNHPLNCFMCHDPHSAGPRVVRDGLINAVVDRGLGTYPHDPVKSEQQGMTKVTFQRGREDFRAIGLLDTADSNVMCAQCHVEYNCNPGYQLSDGSRVGMDDRRANHFFWANVFDYKEAAQEIDFFDFRHATTGAALPKLQHPEAETFWGSVHERNGVACADCHMPKVQLENGKVYTSHSQRTPRDMMGQACLNCHAEWTEDQALYAIDYIKNYTHGKIVKSEYWLAKMIDLFPVAKRAGVSEDVLNQARELHYDAHLYWEWWTAENSVGFHNPDQARESLMTSISKSKEAVSLLNDAIDAQVASR
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (Q7K3D4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform C
- Raptor, isoform B
- Protein LST8 homolog
- RE45833p
- Uncharacterized protein, isoform B
Sequence:
MDTEKSSSSSFEDLTNAEDTKDIRKVAAEEAASGDGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCHVGDYEVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFADLKSFEILRKYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREEHNEKEMYQKMLGQAKKMEQNTATRQKQPLVDNSKLKLLGYLMGTILIGVAGVAIYRYKY
Protein: Vacuolar protein sorting-associated protein 51 (Apical bud growth protein 3) (P36116)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in retrograde transport from early and late endosomes to late Golgi. Links the Golgi-associated retrograde protein (GARP) complex to the t-SNARE TLG1, leading to the fusion between the endosomal vesicles with the late Golgi. May also be indirectly involved in apical bud growth.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12377769}; Peripheral membrane protein {ECO:0000269|PubMed:12377769}. Endosome membrane {ECO:0000269|PubMed:12377769}; Peripheral membrane protein {ECO:0000269|PubMed:12377769}.
Interaction partners:
- Vacuolar protein sorting-associated protein 53
- Vacuolar protein sorting-associated protein 52
- Vacuolar protein sorting-associated protein 54
- t-SNARE affecting a late Golgi compartment protein 1
- GTP-binding protein YPT6
- Protein WHI3
- ADP-ribosylation factor-like protein 3
- Sorting nexin-4
- G1-specific transcriptional repressor WHI5
- Guanine nucleotide exchange factor subunit RGP1
Sequence:
MAEQISHKKSLRVSSLNKDRRLLLREFYNLENEPNKGRQEARIGEKASEAHSGEEQVTDVNIDTEANTEKPVKDDELSATEEDLKEGSEDAEEEIKNLPFKRLVQIHNKLLGKETETNNSIKNTIYENYYDLIKVNDLLKEITNANEDQINKLKQTVESLIKEL
Protein: Early endosome antigen 1 (F1LUA1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDTPYTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPLCMKRCVTAIDLSEHYQQVHTELETRGQELLSDSNVTGFICPQCMKSLGSADELFKHYQAVHDAGNDSGHGGEASLALTRDDIALLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKSDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEEKGLRAAAEQKATHLTEELSKQTTVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSEHANSEATINQLRSELAKGPQEVAVYVQEIQKLKGSVNELTQKSQTLMEKLQKKDLDYTHLEEKHNEEALSRKNTQAALHQRDLDCQQLQARLTASEGSLQRIQGELREKGEAAQKLKEELREVETKHQHLKVEFKQLQQQREEKEQHGLQLQGEVSQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLEKSKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHALQQQLTQLMEKLKNQSESHKQAEENLHDQVQEQKAHLRAAQDRVLSLETSVSELSSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKVSAQLDQVTAKFQEKQEHCTQLESHLKDYKEKHLSLEQKAEDLEGQIKKLEANNLEVKASREQAVQSLQQQRQLSTDLELRNAELRKQLQEQKEVVSHTKLDLQNKSEALENIKQTLTKKEEEKVVLKQEFEKLSQDSEAQHKELSDRMQAAITELMVMTAQKDALLAELSTTKGKLSKVSDSLQTSRSEFEKESQKGKAAVLDLEKACKELKHQLQQQTESALKEQSELKKSLEKERETSQQLMIELNSVKGEVTQAQNTLKQKEKEEQQLQGNINQLKQATEQKKKQMEALQGELKNVTSQKAQLESKLQQQAAQAAQELAVEKGKLSALQSTYDKCQADLQQLQSDLYGKESELLATRQDLKCVEEKLALAQEDLISNRNQIGNQNKSIQELQAAKAALEQDLAKKEEVLKEQSKALQDAQREKSVKEKELVTEKSKLAEMEEIKCRQEKEIAKLKEELKSHKQESIKEVTNLKDAKQLLIQQKLELQGKVDSLKAALEQEKERQQLMREQMRKEEEKRKEEFSEKEAKLHSEIKEKEAGVKKHEENEAKLTMQVTTLNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDLQG
Protein: Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9) (A2APC3)
Organism: Mus musculus (Mouse)
Function: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (Probable). Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305|PubMed:27257088}.
Interaction partners:
Sequence:
MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTSGKKPTGVETQPARANMNPSGSHDTRSSDDQKDDLPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHLKKGCKWMLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREDGPSDLSGMGNFVTNTHLGCVNDRKEQLRQLFRSLQAQRKAPS
Protein: T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Q2T9X2)
Organism: Bos taurus (Bovine)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P50991}. Melanosome {ECO:0000250|UniProtKB:P50991}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P50991}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P80315}.
Interaction partners:
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit beta
- Uncharacterized protein
- T-complex protein 1 subunit zeta-2
- Molecular chaperone MKKS
Sequence:
MPENVAPRTGPPAGAAGAAGGRGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPEELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEQVVQPLLVSVSALTLATETVRSILKIDDVVNTR
Protein: Evasin P458 (A0A0K8R7D4)
Organism: Ixodes ricinus (Common tick) (Acarus ricinus)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL13.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MEVKTFAFLQIAVLIAFSLHSASAGSKQPGAAGSSSDSVEAVFCPTNCTKGTNGAWSGCSDDCICVHVGENTEGSCMKFSGDYDYPTPEA
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) (Q9UL45)
Organism: Homo sapiens (Human)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}. Membrane {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}; Peripheral membrane protein {ECO:0000269|PubMed:12019270}. Note=It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270). {ECO:0000269|PubMed:12019270}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Mirror-image polydactyly gene 1 protein
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- SNARE-associated protein Snapin
- BLOC-2 complex member HPS5
- BLOC-2 complex member HPS6
Sequence:
MSVPGPSSPDGALTRPPYCLEAGEPTPGLSDTSPDEGLIEDLTIEDKAVEQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEFEREKQLTARPAKRM