Protein: Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) (Q80ZA5)
Organism: Rattus norvegicus (Rat)
Function: Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:14592810, ECO:0000269|PubMed:18061361, ECO:0000269|PubMed:28280139}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:28280139}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5DTL9}. Cell projection, axon {ECO:0000250|UniProtKB:Q5DTL9}. Perikaryon {ECO:0000250|UniProtKB:Q5DTL9}. Presynapse {ECO:0000250|UniProtKB:Q5DTL9}. Postsynapse {ECO:0000250|UniProtKB:Q5DTL9}. Note=Detected in dendrites and axon terminals of retinal OFF bipolar cells and in axon terminals of ON bipolar cells. In amacrine cells, located in the perikaryon. Also detected in basal and apical dendrites of hippocampal pyramidal cells (By similarity). Localized to GABAergic inhibitory presynapses (By similarity). In the kidney, isoforms starting with Met-Glu-Ile-Lys localize predominantly to the basolateral membrane of renal thick ascending limbs and inner medullary collecting ducts while isoforms starting with Met-Cys-Asp-Leu localize to the apical membrane of proximal tubules (PubMed:28280139). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000269|PubMed:28280139}.; SUBCELLULAR LOCATION: [Isoform 12]: Apical cell membrane {ECO:0000269|PubMed:31736772}; Multi-pass membrane protein.
Interaction partners:
Sequence:
MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGGESPSFDTPSQRVQFILGTEDDDEEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQSQKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSPQSAPACAENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKTPSLPNGTAAHGGPEQHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSESYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWRESNISASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTAMWGNLLVTADNSKEKESRFPSKSSPS