wanglab/gogpt-training-data huggingface dataset:
Protein: Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-) (O08600)
Organism: Mus musculus (Mouse)
Function: Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA. The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs. Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs. Promotes conservative recombination when the DNA is 5hmC-modified. Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response. GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (By similarity). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q14249}.
Interaction partners:
- Apoptosis-inducing factor 1, mitochondrial
- Diablo IAP-binding mitochondrial protein
- Cytochrome c, somatic
- Cytochrome c, testis-specific
- Zinc phosphodiesterase ELAC protein 2
- Serine protease HTRA2, mitochondrial
- Flap endonuclease 1
- Caspase-9
- Apoptotic protease-activating factor 1
- Apoptosis regulator Bcl-2
Sequence:
MRALRAGLTLALGAGLGAAAEHWRRREGKAPGLLGRVPLLPVVAADLPALPGGPAGGTGELAKYGLPGVAQLRSRESYVLSYDPRTRGALWVLEQLRPERLRGDGDRSACDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQRAMDDTFYLSNVAPQVPHLNQNAWNNLERYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRSYVMPNAPVDETIPLERFLVPIESIERASGLLFVPNILARAGNLKAITAGSK
Protein: Probable circularly permuted 1,3-beta-glucanase TOS1 (EC 3.2.1.39) (Target of SBF protein 1) (P38288)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Secreted {ECO:0000269|PubMed:11935221, ECO:0000269|PubMed:15781460}. Secreted, cell wall {ECO:0000269|PubMed:11935221, ECO:0000269|PubMed:15781460}.
Interaction partners:
- Probable family 17 glucosidase SCW10
- Probable family 17 glucosidase SCW4
- DnaJ-related protein SCJ1
- Cell wall protein ECM33
- Probable secreted beta-glucosidase UTH1
- Probable secreted beta-glucosidase SUN4
- Cell wall mannoprotein PIR1
- Protein TOS2
Sequence:
MLQKLSMTALVGLFSSVVSLVNADCTYSGGNYYCAQTDAIIYSNVGLSATYQDVTNMDESSCACTQADFTASGSLAPFNEELSVHFRGPIELLQFGVYYPNGESNALKKRSEKQSIESCKEGEAVVSRHKHQHKRDVAVEYVQVTSTVYVDSNGQTVTADSTNTVVGPAVPSSYTKDSTVLSSSAQAVETSESQSSISSSKTTSSAAAASSSSSSSSNTNGDWSRGSYFVPGSTSNCTFMNNQGGTAGSGVWSSCFGNSISFAASDGVSGAASAQALGDVTIKSGNEFMIFSGEECSGNNGDCGYYREGIPAYHGFGGADKIFVFEFSMPSDTSGSAYNQDMPAIWLLNAKIPRTLQYGDASCSCWKTGCGEMDLFEILTAGSDKLISHIHDGQDGGTQDYFERPTDGTLKAAVIFNSSDKTIHIIEVDESFDATLSDDVVDQWLSKSGSSAALP
Protein: Probable leucine-rich repeat receptor-like protein kinase At1g35710 (EC 2.7.11.1) (Q9LP24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Jacalin-related lectin 5
- Protein trichome birefringence-like 26
Sequence:
MGFAEKNLYDFRFLLFISIILSCSISASATIAEANALLKWKSTFTNSSKLSSWVHDANTNTSFSCTSWYGVSCNSRGSIEELNLTNTGIEGTFQDFPFISLSNLAYVDLSMNLLSGTIPPQFGNLSKLIYFDLSTNHLTGEISPSLGNLKNLTVLYLHQNYLTSVIPSELGNMESMTDLALSQNKLTGSIPSSLGNLKNLMVLYLYENYLTGVIPPELGNMESMTDLALSQNKLTGSIPSTLGNLKNLMVLYLYENYLTGVIPPEIGNMESMTNLALSQNKLTGSIPSSLGNLKNLTLLSLFQNYLTGGIPPKLGNIESMIDLELSNNKLTGSIPSSLGNLKNLTILYLYENYLTGVIPPELGNMESMIDLQLNNNKLTGSIPSSFGNLKNLTYLYLYLNYLTGVIPQELGNMESMINLDLSQNKLTGSVPDSFGNFTKLESLYLRVNHLSGAIPPGVANSSHLTTLILDTNNFTGFFPETVCKGRKLQNISLDYNHLEGPIPKSLRDCKSLIRARFLGNKFTGDIFEAFGIYPDLNFIDFSHNKFHGEISSNWEKSPKLGALIMSNNNITGAIPTEIWNMTQLVELDLSTNNLFGELPEAIGNLTNLSRLRLNGNQLSGRVPAGLSFLTNLESLDLSSNNFSSEIPQTFDSFLKLHDMNLSRNKFDGSIPRLSKLTQLTQLDLSHNQLDGEIPSQLSSLQSLDKLDLSHNNLSGLIPTTFEGMIALTNVDISNNKLEGPLPDTPTFRKATADALEENIGLCSNIPKQRLKPCRELKKPKKNGNLVVWILVPILGVLVILSICANTFTYCIRKRKLQNGRNTDPETGENMSIFSVDGKFKYQDIIESTNEFDPTHLIGTGGYSKVYRANLQDTIIAVKRLHDTIDEEISKPVVKQEFLNEVKALTEIRHRNVVKLFGFCSHRRHTFLIYEYMEKGSLNKLLANDEEAKRLTWTKRINVVKGVAHALSYMHHDRITPIVHRDISSGNILLDNDYTAKISDFGTAKLLKTDSSNWSAVAGTYGYVAPEFAYTMKVTEKCDVYSFGVLILELIIGKHPGDLVSSLSSSPGEALSLRSISDERVLEPRGQNREKLLKMVEMALLCLQANPESRPTMLSISTTFS
Protein: Small ribosomal subunit protein uS3c (30S ribosomal protein S3, chloroplastic) (P0C485)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS9
- 60S ribosomal protein L2
- 60S ribosomal protein L29
- 40S ribosomal protein S29, putative, expressed
- Os08g0116500 protein
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS2c
- 40S ribosomal protein S12
- Os10g0411700 protein
- 40S ribosomal protein S12
Sequence:
MGQKINPLGFRLGTTQNHHSFWFAQPKNYSEGLQEDKKIRNCIKNYIQKNRKKGSNRKIEADSSFEVITHNKKMDSGSSSEVITHIEIQKEIDTIHVIIHIGFPNLLKKKGAIEELEKDLQKEVNSVNQRLNIGIEKVKEPYRQPNILAEYIAFQLKNRVSFRKAMKKAIELTKKTDIKGVKVKIAGRLAGKEIARAECIKKGRLPLQTIRAKIDYCCYPIRTIYGVLGVKIWIFVDEE
Protein: Testicular tissue protein Li 27 (A0A140VJF3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKST
Protein: Nucleolar protein 58 (Nopp140-associated protein of 65 kDa) (Nucleolar protein 5) (Q9QZ86)
Organism: Rattus norvegicus (Rat)
Function: Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y2X3}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y2X3}. Note=Localizes to the nucleolus with a minor part present in the nucleoplasm. {ECO:0000250|UniProtKB:Q9Y2X3}.
Interaction partners:
- NHP2-like protein 1
- Nucleolar protein 56
- H/ACA ribonucleoprotein complex subunit DKC1
- U3 small nucleolar RNA-interacting protein 2
- rRNA 2'-O-methyltransferase fibrillarin
- WD repeat-containing protein 75
- HEAT repeat-containing protein 1
- NOP14 nucleolar protein
- U3 small nucleolar RNA-associated protein 4 homolog
- WD repeat-containing protein 43
Sequence:
MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASATLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGAENRAKLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEITEKKAKKAKIKIKAEVEEEMEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAVPSPEKKKKKKKKKDAED
Protein: Translationally-controlled tumor protein (Q5W0H4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKCVSTRKWVKINNVKKTF
Protein: Protein RICE FLOWERING LOCUS T 1 (FLOWERING LOCUS T-like protein 3) (FT-like protein 3) (OsFTL3) (Q8VWH2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable mobile flower-promoting signal (florigen) that moves from the leaf to the shoot apical meristem (SAM) and induces flowering. Promotes the transition from vegetative growth to flowering under long day (LD) conditions. Acts upstream of MADS14 and MADS15. May also participate in the promotion of flowering under short day (SD) conditions.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000269|PubMed:28254780}. Endoplasmic reticulum {ECO:0000269|PubMed:28254780}.
Interaction partners:
- Os07g0295200 protein
- Protein HEADING DATE 3A
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS2c
- Os02g0102400 protein
- Large ribosomal subunit protein mL46
- Os08g0513300 protein
- Large ribosomal subunit protein bL27c
- Large ribosomal subunit protein uL5c
- Small ribosomal subunit protein uS14c
Sequence:
MAGSGRDDPLVVGRIVGDVLDPFVRITNLSVSYGARIVSNGCELKPSMVTQQPRVVVGGNDMRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPGTTGATFGQEVMCYESPRPTMGIHRLVFVLFQQLGRQTVYAPGWRQNFSTRNFAELYNLGSPVATVYFNCQREAGSGGRRVYP
Protein: Enoyl-CoA hydratase ChsH3 (EC 4.2.1.-) (Q6MWW2)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Degradation of the cholesterol side chain involves 3 multistep beta-oxidation cycles, this is involved in the second cycle. Hydrates bulky steroid enoyl-CoA esters, has highest activity with 3-OCDO-CoA (3-oxochol-4,22-dien-24-oyl-CoA) making (22S)-HOCO-CoA, followed by octenoyl-CoA, with weaker activity on 3-OCDS-CoA (3-oxocholest-4,24-dien-26-oyl-CoA) and none on 3-OPDC-CoA (3-oxo-pregna-4,17-diene-20- carboxyl-CoA). Hydrates the same substrate as EchA19, but the 2 enzymes make different stereoisomers of the product.
Interaction partners:
- 3-oxosteroid 1-dehydrogenase
- Probable short-chain type dehydrogenase/reductase
- Putative short-chain type dehydrogenase/reductase Rv0148
- Hydroxyacyl-CoA dehydrogenase ChsB1
- Uncharacterized oxidoreductase Rv1350
- 3-oxoacyl-[acyl-carrier-protein] reductase
- 4-hydroxy-2-oxohexanoate aldolase
- Uncharacterized oxidoreductase Rv0769
- Probable acyl-CoA dehydrogenase FadE31
- 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase
Sequence:
MPIDLDVALGAQLPPVEFSWTSTDVQLYQLGLGAGSDPMNPRELSYLADDTPQVLPTFGNVAATFHLTTPPTVQFPGIDIELSKVLHASERVEVPAPLPPSGSARAVTRFTDIWDKGKAAVICSETTATTPDGLLLWTQKRSIYARGEGGFGGKRGPSGSDVAPERAPDLQVAMPILPQQALLYRLCGDRNPLHSDPEFAAAAGFPRPILHGLCTYGMTCKAIVDALLDSDATAVAGYGARFAGVAYPGETLTVNVWKDGRRLVASVVAPTRDNAVVLSGVELVPA
Protein: cystathionine gamma-lyase (EC 4.4.1.1) (Gamma-cystathionase) (Q7JXZ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cystathionine beta-synthase
- FI01821p
- Betaine-homocysteine S-methyltransferase
- Branched-chain-amino-acid aminotransferase
- Sulfurtransferase
- Cysteine dioxygenase
- GH04035p
- FI04487p
- Adenosylhomocysteinase
- Aspartate aminotransferase
Sequence:
MSYRVQPSGFATKSIHSGQSPDQWKSAAVIPPISLSTTFKQDAPGEHRGYEYSRSGNPTRNVLETCFAALDNAKYGLTFSSGLGATTAVLTMLSSGDHIIMGDDVYGGTNRLIRQVATRLGISATFVDPTKLDLIKSSIKPETKLVWIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSLTKYMNGHTDVVMGGITMNSEKLYKSLKFLQNAVGIVPSPFDCYQVNRSLKTLSLRMEQHQKNALKVAKYLETNPFVEKVLHPSLPSHPQHKIALKQAYGYSGVFSFYIKGELKHSSAFLKALKVFTLAESLGGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLEQALEIASKA
Protein: Polyamine transport protein PotI (Q9I6I7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Polyamine transport protein PotH
- Spermidine-binding periplasmic protein SpuE
- Putrescine-binding periplasmic protein SpuD
- Spermidine/putrescine import ATP-binding protein PotA
- Probable periplasmic spermidine/putrescine-binding protein
- Probable periplasmic spermidine/putrescine-binding protein
- Putrescine/agmatine-binding protein
- Probable binding protein component of ABC transporter
- Putrescine/cadaverine-binding protein
- Probable binding protein component of ABC transporter
Sequence:
MKRWNFSNVMLIVGLLFIYLPMLILVIYSFNASKLVTVWGGWSVKWYVGLLDNTQLVSSVGRSLEIAFYTAFSSVFLGTLAAFVLTRIPRFRGRTLFGGMVTAPLVMPEVITGLSLLLLFVAMAQLIGWPQERGIVTIWIAHTSFCSSYVAVVVSARLRELDLSIEEAAMDLGAKPWKVFLLITIPMIAPSLAAGGMMSFALSLDDLVLASFVSGPGSTTLPMEVFSAVRLGVKPEINAVASLILLSVSLFTFFAWYFTRQAEERRRRAIQQAMEETATDWQKGSPTPA
Protein: Aspartate carbamoyltransferase catalytic subunit (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) (P0A786)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Aspartate carbamoyltransferase regulatory chain
- Carbamoyl phosphate synthase small chain
- Carbamoyl phosphate synthase large chain
- Dihydroorotase
- Dihydroorotate dehydrogenase
- Allantoinase
- Orotidine 5'-phosphate decarboxylase
- Orotate phosphoribosyltransferase
- D-phenylhydantoinase
- Adenylosuccinate synthetase
Sequence:
MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL
Protein: Protein rapunzel (F1QUP1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MADNELFDDPEKLKRGLVKVLECVATISSAAAVVNPIFGVAGSLIRVVLHHVDDEDLQKLKREFGSVNRALDEISQQNRQALLQIRKETVDRQYHEVEENIRHQFRKFMEIMEAKPEHLQRKKEDFVESFINDKDDQNMYTLYDGVMGKRKLFSQPILDVYMKHSQGDHRVMENLCTRLAYLFCIGFIALMGYYGILGDDLESRNEEWEENMRNVQEKMQEVLRSCK
Protein: ADAM metallopeptidase domain 22 (A0A8I6G6D0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MQAVAAAFFWLLCVLGTYPLARCGRAGDASLRELERGDGNRFLERQSTVPLRLIYRLGGEDETQHEQLNTRVRGDPGGRQPTHVDKASFRVDAFGTSFILDVLLNHELLSSGYVERHIEHGGKVVENKGGEHCYYQGQIRGNPASFVALSTCHGLHGMFYDGNHTYLIEPEENEMSQESQFHSVYKSRLLEFPLDDLPSEFQRINITAPQFTLKPRLKRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLVTLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGFLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPMASFNFSTCLSNKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNVGGNKKKIRGKRFRPRSNSTEREPQAPEPGHSLAQTSPGISPGGSDSPQTGSLDHRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEEKTVNRQSARLWETSI
Protein: Putative protein RDUR (RIG-I dependent antiviral response regulator RNA) (Q0VG73)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNNSFNKEDRMSSDTMVGSCDRQTKNGAKWHGGVSSLLDFTLIYIQLSTSFQNAGHSFKKQHICSDFEVMDELSCAVYGNKFYYLLPTLTHPSIQ
Protein: Coilin (p80-coilin) (P38432)
Organism: Homo sapiens (Human)
Function: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
Subcellular location: Nucleus {ECO:0000269|PubMed:7679389}. Nucleus, Cajal body {ECO:0000269|PubMed:16079131, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:23726919, ECO:0000269|PubMed:7679389}.
Interaction partners:
- Nucleolar and coiled-body phosphoprotein 1
- Survival motor neuron protein
- rRNA 2'-O-methyltransferase fibrillarin
- Ataxin-1
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Spliceosome associated factor 3, U4/U6 recycling protein
- Telomerase Cajal body protein 1
- Proteasome activator complex subunit 3
- Gem-associated protein 2
- U3 small nucleolar ribonucleoprotein protein MPP10
Sequence:
MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISLIRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDINLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSKKNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSSPKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLPTELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTPECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLGRGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTIIQNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIESPSNTSSTEPA
Protein: Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1) (Q6GNL4)
Organism: Xenopus laevis (African clawed frog)
Function: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19767740, ECO:0000269|PubMed:27158779}.
Interaction partners:
Sequence:
MSVTPVLDPEWQRSPEGLDYLSRVLRHNKRKFFGLIERPVLPPHLPADVAAYKVFVCGKSGVGKTSFIAKLSGLAVPSMHHETAGIQTTCMYWPVRPSGSARPVIFRFQFWDCGEGALRKFDHILPACKEKADAVLFLFSFTDRSSFEDVPALISRTLDQDEDVTRVVIGTKLDQYMHTDVTEDDLRDFQRTWQLPVMRVRSVNGPRMTDGRDLDGRAGLAECAPVLNGLAEILWHRDQVIAGLVGGAE
Protein: Keratin-associated protein 10-2 (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2) (P60368)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MAASTMSICSSACTNSWQVDDCPESCCELPCGTPSCCAPAPCLTLVCTPVSCVSSPCCQAACEPSACQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCGASSCCQQSSCQPACCASSSCQQSCRVPVCCKAVCCVPTCSESSSSCCQQSSCQPACCTSSPCQQSCCVSVCCKPVCCKSICCVPVCSGASSPCCQQSSCQPACCTSSCCRPSSSVSLLCRPVCSRPASCSFSSGQKSSC
Protein: Heparan sulfate 3-O sulfotransferase-B, isoform A (EC 2.8.2.-, EC 2.8.2.23) (Heparan sulfate 3-O sulfotransferase-B, isoform B) (RE01736p) (Q9VWJ7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase
- Heparin sulfate O-sulfotransferase
- Dally-like, isoform A
- Extracellular sulfatase SULF-1 homolog
- Syndecan
Sequence:
MRDTAATSAQPAMIVMSIWCSSLSLSSRSLAIALVICVTLVYFSYSFNACLLASISRSLQQSNLRNLLALTSSPRNETNNAANSSSSNSSSSRNSSSTTGAPPAQTVTSSLDGAPKYQLLRQQGLRPSRHLPDTLIIGVKKSGTRALLEFIRLHPDVRAAGSEVHFFDRHYQRGLRWYRHHMPYTIEGQITMEKTPSYFVTKEVPQRVYHMNPATKLLIVVRDPVTRAISDYTQAASKKADMKLFEQLAFVNGSYSVVDTNWGPVKIGVYARYLERWLLYFPLSQLLFISGERLIMDPAYEIGRVQDFLGLKRVVTEKHFYFNATKGFPCLFKSEARSTPHCLGKTKGRNHPHIDPGAIERLREFYRPFNNKFYQLTGINFAWP
Protein: Hepcidin (Q4G2S4)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRAMSIACAVAVIIACVCALQSAALPSEVRLDPEVRLEEPEDSEAARSIDQGVAAALAKETSPEVRFRTKRQSHLSLCRYCCNCCKNKGCGFCCRF
Protein: Imitation switch two complex protein 1 (P53125)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. ITC1 is required for nucleosome-stimulated ATPase activity and chromatin-remodeling activity of the complex. Required for the repression of MATa a-specific genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11238944}.
Interaction partners:
- DNA polymerase epsilon subunit D
- ISWI chromatin-remodeling complex ATPase ISW2
- Protein DLS1
- ISWI chromatin-remodeling complex ATPase ISW1
- ISWI one complex protein 3
- ISWI one complex protein 2
- ISWI one complex protein 4
- Non-histone chromosomal protein 6B
- RFX-like DNA-binding protein RFX1
- Chromo domain-containing protein 1
Sequence:
MVLYKRKPILLPDPKPLPLDLNVQVWHIEETGEWFSSYEEFLERFDFYTRHHFTCEITGTSCLTFFQALDSEETQFKYVEDRFPLKLREPVARFLHFNGIRRLDALVEKVYARFKNDFFPGEVVYLRKQKDSSTTSSNSQQSTPQPDDMVEINSVGNPGLPQYQYQRRYVIKEKVQFNATINPESREIVMPAHTKYMLIEEAASSNKSFIVDQGQIYRDRSTFTKHLIKCFFKITLQRASSKMGAPWCVKPEYLAMYGLTMEWPKDMLKYKEDEPVVARRSNSANVSSPESEKNKRQSKSSGKSNTSNDASNKKETKKKRKPTEVNDSENNSSEEDKKKGQNVTSETHSKKRKKEANEEPNTENVESVPTPANAEPQAVTITSIMDDLALPYQHPPNIFPNLTYYNEKLECISLGSTKLSRPFDSFGKLLQAYQFLNTFGSKICLSHFSLDQFITSLKCTDPYELKGEVVLVNIRTQTSKEQEIENNGLPMKNKAETTTEEDSENPSDWQRNSFIRDMIMKRNSDKVEYKIVHDDPASDDILDNINHNGSALLIEVFTALLRLFINEEGDWSCIVVENWIIDDKGVLMERKDERGEGEAKQKRNAHGYFLQDKEKIDNLKDTLKENATEVQKESDAKNETNSESDSKSDSDSEERDPKLEKCLNYRNVNWIERLTKRQFNNSYWLIILLGVLEDCRHLPMYTEFIDSFIEKIIPKDISATQLPKQLWRNFCRKLSFSDKVNALWILVDLVSHFSPDIKAAVDDSMELCGQIRSERFKVARELKTEAAVLSNLQGDLQAIQEKLNKTDENTPSADGADKKDDSESNSEPIDLIIIEKKQKLIEEQDKKVQALQSDKNFLDNCLFENDLQRLKPLGLDRYGNRYFWLDHNGVPFPQYPAGMNETPKSNNSLSYHSGRLLIQGPKASSAKFFLNVSDEQLSNWQKIRNSEGISEATREVFGISKTSSGSYNYVENGIEVELLDSNDRVNPLIELTPIQKKIMDETPSRLLLSPDQWYCIDKLEDLSRIMDWLDNWGRKEHDLLRQIRPIMERIKSSLSLRDHALSLTAFTKNEEKLLKELENNEFTENELNVDSMDVDDKNSGVKSEVDVQVDAEEKREAVIDEKLEVIADELMKLDDSSKTRNVLNRIQELEDQRDELLEQKKSIINSQRPGARILARSERKRTKISRGNKVNKQIEILTDLVNYRHFKAMEDVIAWKNVLANSIWGSSLRKNASGNKRSGVIETVDDKLKDIVGQTSRTVTPAPN
Protein: CDGSH iron-sulfur domain-containing protein 2 (MitoNEET-related 1 protein) (Miner1) (Nervous system overexpressed protein 70) (Q9CQB5)
Organism: Mus musculus (Mouse)
Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19451219}; Single-pass membrane protein {ECO:0000269|PubMed:19451219}. Mitochondrion outer membrane {ECO:0000269|PubMed:19451219}; Single-pass membrane protein {ECO:0000269|PubMed:19451219}. Note=According to PubMed:19451219, it mainly localizes to the mitochondrion outer membrane and localizes only at low level to the endoplasmic reticulum. However, inverse results are observed in human cells.
Interaction partners:
- Wolframin
- Mitochondrial import inner membrane translocase subunit Tim10
- CDGSH iron-sulfur domain-containing protein 3, mitochondrial
Sequence:
MVLDSVARIVKVQLPAYLKQLPVPDSITGFARLTVSDWLRLLPFLGVLALLGYLAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV
Protein: Ras-related protein RABH1b (AtRABH1b) (Ras-related protein Rab6A) (AtRab6A) (O80501)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Binds GTP and GDP and possesses intrinsic GTPase activity (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:19454595}; Lipid-anchor {ECO:0000305|PubMed:19454595}. Cytoplasm, cytosol {ECO:0000269|PubMed:19454595}.
Interaction partners:
- Golgin candidate 5
- Vacuolar protein-sorting-associated protein 33 homolog
- Vacuolar protein sorting-associated protein 52 A
- Guanosine nucleotide diphosphate dissociation inhibitor 2
- Vacuolar protein sorting-associated protein 54, chloroplastic
- Vacuolar protein sorting-associated protein 53 A
- Guanosine nucleotide diphosphate dissociation inhibitor 1
- Guanosine nucleotide diphosphate dissociation inhibitor At5g09550
- Conserved oligomeric Golgi complex subunit 6
- Geranylgeranyl transferase type-2 subunit beta 1
Sequence:
MAPVSALAKYKLVFLGDQSVGKTSIITRFMYDKFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDVASRQSFLNTTKWIDEVRTERGSDVIVVLVGNKTDLVDKRQVSIEEAEAKARELNVMFIETSAKAGFNIKALFRKIAAALPGMETLSSTKQEDMVDVNLKSSNANASLAQQQSGGCSC