Protein: TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin) (Q99KW3)
Organism: Mus musculus (Mouse)
Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
Subcellular location: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q9H2D6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9H2D6}. Midbody {ECO:0000250|UniProtKB:Q9H2D6}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-445 and lasts from prophase to anaphase. At telophase, relocalizes to midbody (By similarity). {ECO:0000250|UniProtKB:Q9H2D6}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell projection, stereocilium {ECO:0000269|PubMed:31217345}. Note=Restricted to the lower half of rootlets, immediately below the apical surface of a hair cell within the cuticular plate. {ECO:0000269|PubMed:31217345}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell projection, stereocilium {ECO:0000269|PubMed:31217345}. Note=Detected in the upper half of rootlets embedded in stereocilia cores. {ECO:0000269|PubMed:31217345}.
Interaction partners:
- Pejvakin
- Xin actin-binding repeat-containing protein 2
- Spectrin alpha chain, non-erythrocytic 1
- Spectrin beta chain, non-erythrocytic 1
- Taperin
- Espin
- Whirlin
- Fascin-2
- Myosin-IIIa
- Unconventional myosin-XV
Sequence:
MSMEQDTRALLPTQGTAWATASAPVARLQGPQGDSHQACSQEPHSPSSAEAPYCDLPRCPPALQNPLRTTTCVGQSVHSLGLGLGQEPQRVWSPTTALPAEGPAAAPKNRHQDSEGIPYLEGLARSSCTDDNDNKDEDEDPNSNTSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGQRKENSGSGGQSAGQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPCVQDSSLNRTSQRDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQADKTTASCSKWEHLRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQVCIGHRDAPRASSPPRHPPSDIGLLAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRGPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQTRDEGRSQRPSQAQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPDKRPEGDRQLQRTSPPARTPARPPERKAQIERHLESGHTGPRQSLGGWQSQERLSGPQSPNRHPEKSWGSQKEGPSLGGWPELEGPSLEGIWRGPPQEHREQWGHSEAWEEPPSNGIQGAPPRGQGRLQELSRPHQPTPSSENSWAGPAECSCALQPEASTAVGWRAEGTSPHQRSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPARHWHDPAKASGPEQGSSGTEDTLKTEPQTQPEGRAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPLAALEQIDHLESHSPPDLEFQPEEPEASEPSRGEDSRAVQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDCNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKADGPRPSLDYVELSPLAPSSPQRMRTLSRSTPERPTKQEDLERDLAQRSEERRKWFESTDGRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQAHNDRRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPESLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRRCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE