wanglab/gogpt-training-data huggingface dataset:
Protein: Formylmethanofuran--tetrahydromethanopterin formyltransferase (Ftr) (EC 2.3.1.101) (H4MPT formyltransferase) (Q49610)
Organism: Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Function: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR) (By similarity). Acts via a ternary-complex mechanism. Uses N-furfurylformamide much less efficiently, does not use N-methylformamide or formamide. Protein overexpressed in E.coli has very similar properties to enzyme purified from M.kandleri.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00579, ECO:0000305|PubMed:1483480}.
Interaction partners:
- Formylmethanofuran dehydrogenase subunit A
- Methenyltetrahydromethanopterin cyclohydrolase
- formylmethanofuran dehydrogenase subunit B
- formylmethanofuran dehydrogenase subunit B
- Uncharacterized protein conserved in archaea
- Formylmethanofuran dehydrogenase subunit D
- formylmethanofuran dehydrogenase
- Tetrahydromethanopterin S-methyltransferase subunit H
- Tetrahydromethanopterin S-methyltransferase subunit A
- Acetyl-CoA decarbonylase/synthase complex subunit beta
Sequence:
MEINGVEIEDTFAEAFEAKMARVLITAASHKWAMIAVKEATGFGTSVIMCPAEAGIDCGYVPPEETPDGRPGVTIMIGHNDEDELKEQLLDRIGQCVMTAPTASAFDAMPEAEKEDEDRVGYKLSFFGDGYQEEDELDGRKVWKIPVVEGEFIVEDSFGITTGVAGGNFYIMAESQPAGLQAAEAAVDAIKGVEGAYAPFPGGIVASASKVGSKQYDFLPASTNDAYCPTVEDNELPEGVKCVYEIVINGLNEEAVKEAMRVGIEAACQQPGVVKISAGNFGGKLGQYEIHLHDLF
Protein: X-linked retinitis pigmentosa GTPase regulator homolog (Gut granule loss protein 4) (Q5DX34)
Organism: Caenorhabditis elegans
Function: Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons.
Interaction partners:
- F-box/SPRY domain-containing protein 1
- Ras-related protein Rab
- mRNA export factor rae-1
- Mitogen-activated protein kinase kinase kinase dlk-1
- Protein phosphatase ppm-1.A
- Probable protein phosphatase 2C T23F11.1
- E3 ubiquitin-protein ligase rpm-1
- Mss4 protein
- AP-3 complex subunit mu
Sequence:
MFFKRSTNSRKTSANSSSDTSTSSESLLLPLLNNTKAGARSQKGSVHRQSGKKARRKMMENPYVCSLELDELSADDSIIDYSVFSDDSFLLILLLTSKGDVQAYLETSRDTKPRKNVVNIKTACSLNVSPVTVCIGSQAAFAIFGLADGNLLVTPIRLLIDVTWGGSSWATTTVIDLSLPTVDPCLATPTCTKCFVSNFPPCTMAVVANKAGNILLVDLHLRKCVSELKAPQSLHQIDILLDENSIELLVTGFTGAQWIIPIERSGKGFREVLTTCVPSDLTVLEPATMQFFAADSCGVVALDTTESIVEVYNTFHSLAHSSKRTFKVPPETWMVHAGDNMLFTVSNDNEIRSALHFGFMSSRLEYTLVRTSTNWRPLGIVAMPSRPHKLAGIFVVNERGLVRVEQSTALNLTKIASEFFFRLSPLQLNSKSVAQVANACRIDTAEFQSALIPNLLSTRKNRQLTNKELSQIYSIAKAINLSMSDLLKAFENESIGEQLLPEVLNTIQTNPAKHDNLMQRVVEMFVKRSLSAEGNMDKIREYDAELSNFLARHEHLHKGSVDCAKAGMWKCTQTLVRRDVHETKSIDTSTEVLLYIIKNRLQIWNEANSTDRLQIMSLVCHLDWSKLADADGARVCAILSAWQRDISLPSYHEMCLRIAITNSDRFPRPCQILSLVSSIHILSEKKISNHANLPNFLPLAGGNNCGATITEDDRLMIWGNFTNAQQRMEMPQMNAKSKRSDSVTNGAPTLPPPAPKPEQHLPRVLEYPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDGDWPAIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICKVTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGNSADVTKKFFFQARDGRRFMPNVDESQFVQKPGLIPDVRVRNLNEDGNEGVDKEEIVDRLKASDVNVVQAVSKHLYSPIEGKCNGSIIEDEPRNGKIQKQNKYDGEDGPLCTTTALVHLIAGDVKRAIRMIEWLKTDSSTCEKSLMVLSSLVWEVMANHEDVQSREALSAAFRHVPMSDSMRKGKQIAQLWPAVWNDERVQSSLSIDEKIAMLDGFTSASKPVSCPTIPSSSLEVSSKIRVYAQCAHAEPAAVGSPPECSTCLDEWTEKVRHTLGTQL
Protein: Jumonji/ARID domain-containing protein 2 (Q9US53)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit a
- ATP synthase subunit alpha
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit 5, mitochondrial
- JmjC domain-containing protein 1
- JmjC domain-containing protein 4
- ATP synthase subunit d
- ATP synthase subunit 4
- ATP synthase subunit g, mitochondrial
Sequence:
MSKSTFHQTSPSFVQYTHATDKLKPAPHGMNTRGNNLSSMSKNTGQRKQRSKSIHGLPVAPVFYPDKEEFQDSIGYINKIAPIGEKYGIIKIVPPAGWNPPMQLDMNKFSFRTRRQDLHMMDLRFREIVSYDERVYRFFCNLGMELPESFFISNTSIDLYSLMRCIDSHASLSEKELKVHVWKRILRELSIPFTNASLKEASDLYLRYIFPFEDFVRKYQTSEDQCFETDLFPKFFTKDEHSNISIKDQKTSKQFNPETNESVGILQNQESKRNEQIKQQYMPADNFGSNDNHSHNKKRRLSSLSTNNNHLCDNCHKPVNCEVEDTCKEAYCTKCIINPYEFGFETGNYYTLSNFEKYCDNFKKNYFSKFKDSEITEDIVEKEYWKLVKDNNTSLEVEYGADLSTLDQGSAFPSLAKNPVNPYSKDTWNLNVIASTNGSLLSYIDNPVSGITCPWLYVGMCFSTFCWHVEDNYTYSVNYQHYGDTKLWYGIPGDQAERFERAALDIAPDLVKKQKDLLYQLATMINPDELQKRGVDVYFIDQGPNEFVITFPKSFHAGINHGFNINEAVNFAPKDWLLNGFSLNGVLKYQSLLKPPVLSHDMLVYNLATNPASEISVSELRPWVHEAVKRELGIRIMIRGRYDLKEILYRELMEDAENWQCQHCKAFSYFSQVACSCKSITVCPLHIEYLCKCDLSNKTLRLKVDDNELQKLLSY
Protein: Protection of telomeres protein 1 (H7BX60)
Organism: Mus musculus (Mouse)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Telomeric repeat-binding factor 1
- TERF1-interacting nuclear factor 2
- Telomeric repeat-binding factor 2
- Tripeptidyl-peptidase 1
- Adrenocortical dysplasia protein
- CST complex subunit CTC1
- Telomeric repeat-binding factor 2-interacting protein 1
- CST complex subunit STN1
- Protection of telomeres protein 1
- CST complex subunit TEN1
Sequence:
MSSAPVAPSTYTPLNLLKEGTVVNVCGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCMLFSRDYDTLPSVYKVGDIVCFQGLKIQAYKNELQAISKFGFASLTFDGTLGAPIILRTLSKRFNFTAQDYSMVEALRTWASTHISASSNLVQLSDAQPMQYYDLTCQLLGKAQVDGVSFLLKVWDGTRTKIPSWRVCIQDVAFEGDLSHILQLQNLVVDIVVYDNHVQVAKSLKIGSFLRIYSLHTKLQPINSESTTSLVRLEFHLHGGTSYGRGIRVLPESNYDVDQLKKALESVDLEAIQTSDDTYQSDNVENCLTSSSSESDLVSLYEVERCQPLCATTLTGYHHLEKTSLCDILKQRAPRQYRIRAKLRSYKPRRLPQSVKLFCPKCHLLQEIPSEENVDKILQDATATAPDCKLQDTPLYDSEVWTTEGQGGRQVAVHFVKNDGVLPHSSECLVLIEGGRLCEISRLSSMFHSVIPVRSGPEDLELVDLAAPFLIRGKVCHYGCKQCSNLKTIQNLSIIPNKRLWIPSSVAEVLGIVPLQYVFVMTFMFDDGTGVLDVYLKDSEKFFQIPASEVLTDDDLQRNLEQIMNVICPPGIKIDAHPWLECLIKSYNVTSGTEHQICYQIFDTMIAEDII
Protein: BAG family molecular chaperone regulator 4 (Bcl-2-associated athanogene 4) (Q8RX71)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses.
Interaction partners:
- BAG family molecular chaperone regulator 5, mitochondrial
- BAG family molecular chaperone regulator 7
- Heat shock 70 kDa protein BIP2
- BAG family molecular chaperone regulator 6
Sequence:
MMHNSTEESEWEVRPGGMLVQRRDDAASSDHKPLQDPDSASAAFAQTIRITVSHGSSHHDLHISAHATFGDVKKALVQKTGLEASELKILFRGVERDDAEQLQAAGVKDASKLVVVVEDTNKRVEQQPPVVTKEMEKAIAAVNAVTGEVDKLSDRVVALEVAVNGGTQVAVREFDMAAELLMRQLLKLDGIEAEGDAKVQRKAEVRRIQNLQEAVDKLKARCSNPFVDQSKAAAVSTEWESFGNGVGSLNPPPPASPSANVTQDWEKFD
Protein: Mitochondrial import inner membrane translocase subunit tim14 (Presequence translocated-associated motor subunit pam18) (Q9UT37)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (ssc1) (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim16
- Mitochondrial import inner membrane translocase subunit tim44
- Mitochondrial import inner membrane translocase subunit tim17
- Mitochondrial import inner membrane translocase subunit tim23
- Mitochondrial import inner membrane translocase subunit tim50
- GrpE protein homolog
- Mitochondrial import inner membrane translocase subunit tim21
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- Protein mgr2
- Cytochrome c oxidase subunit 4, mitochondrial
Sequence:
MSSAILLGVGIAATAAAGKIGVDAFRKYRNLNGGVKAFLKGGFESKMSRAEAIQILSLNNRTLTRQKIKEAHRRLMLANHPDRGGSPYVASKVNEAKSLLDADRSIRKFSSWALPVSKQRSMPSVLEAVKWLEYSSIPKA
Protein: Late embryogenesis abundant protein 50 (LEA 50) (Q9FK14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: LEA proteins are late embryonic proteins abundant in higher plant seed embryos. The function of those proteins is not known.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25005920}. Nucleus {ECO:0000269|PubMed:25005920}.
Interaction partners:
- Late embryogenesis abundant protein 6
- Putative cytochrome c oxidase subunit 6b-like
Sequence:
MMFGFGLLKQYAGTTEQISTAAEALVGRSTTLTEALKAAAINVGRKPVETTDLAAIKEVEARAIGGDIESDGGVTAVASKAVARNQKIGEDNEKTNLGDVIAEIDVKVTRDREVTSEDAEAVIRAELNHSPFNNIIPGGVAESVTAAYKLNCNPCNVSL
Protein: Transcription factor stalky (GATA zinc finger domain-containing protein 1) (Q550D5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable transcription factor. Seems to act on the expression of the genes culC, culD, rnpA and sigB.
Subcellular location: Nucleus {ECO:0000269|PubMed:8898200}.
Interaction partners:
Sequence:
MMGEFHTQFQQIKQNNINNNNNNNNNNSNNNNNFDPITSLTNNNNNKIISPLNSNRQQPNSNTNNNSNNKNNNKSNLLDIILDNNNLENNIDNNNNNNNNNNNNNNNNNNNNSKSIINLIDNNNNNNKNNNNNNNNNNILKIPIDYTPVDKNTESIFKGFSPFSFKQQQPIDTSDQQQKETKKLQLNINSNNKNNNNIINNSNNNNNINNIESNNNNLNSASTSPIPTPTSLTAVSVPSSSPLPSPTSPNTILQSPTTTTTTTTTTSNSSVSPQPTQINKTDKYLLPMSAPRSCEFCGSSQTPTWRRGPSGKGSLCNACGIKWRLKGKDGIFKPSQKQQNRQKPIMSAQKQPKQQQNQPQQQQPQQPQQPQQPQQQNQQQNQQQSIQSQPQQRQNNHLILNQQTINQHLQMLSKQHQQQASQSMFQQQQLHNNQHSNDSNYNSYNNNNNNNNNNYSQHEQLPPISSYNSMNNNNNSNNSNNNNNNNNYSQIPQYGSDDNVSVPNQSPDSYKPSKKRKPEFIHTDTSGNPIEFEKGYYCKYCKKTWPQSSFRNSQQFGAHCSNCSRKPKGELEELISIKKKLSKKKSKEGNYYQEEDGAVPYWDMNRYNNNNNNNNGINNNNNNNNNNNNNNSNNNGSYNNNNSNNNNNNNRIEPIVNNNINNFNSINNNNSNNNNNNNSTSQNAPLLQRLIHVVENQLLEPNELSSIREDIDIMKNDLILRKKKRIAQLNDLKQKANNDVQILKANIEKGSNQRSNESKSFITDLKQEIDKRLNQYTHIYIPPDHHLVPSSTNYLSIDSLQNSSSSNNYGTIHNSNNNNNNNNNNNKRSLVNLSPELIHSPLKKPMVGGYRDEQGMKHFSIDGDNLSLPSIS
Protein: Thioredoxin superfamily protein (F4IUG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVAATVNLANMTWTSLNSNPAISFSMLSGIRNLGMLPFRRCLKPTVIGIASWPPLRCSSVKAMSSSSSSSGSTLEETVKTTVAENPVVVYSKTWCSYSSQVKSLFKSLQVEPLVVELDQLVSLGKTSLPHDIGLKHLQKFWWFLAFPGSEGSQLQNVLEKITGQYTVPNVFIGGKHIGGCSDTLQLHNKGELEAILAEANGKNGQT
Protein: Ankyrin repeat domain-containing protein 16 (A2AS55)
Organism: Mus musculus (Mouse)
Function: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29769718}. Nucleus {ECO:0000269|PubMed:29769718}.
Interaction partners:
- Alanine--tRNA ligase, cytoplasmic
Sequence:
MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGTLAQQLTRSVDILQDFDHDVKS
Protein: Phosphodiesterase (EC 3.1.4.-) (Q91VY2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
ASLQPLQPNYLSVCLFPEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPIDT
Protein: Matrix protein (Phosphoprotein M2) (P0DOF2)
Organism: Rabies virus (strain ERA) (RABV)
Function: Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons.
Subcellular location: Virion membrane {ECO:0000250|UniProtKB:P16287}; Peripheral membrane protein {ECO:0000250|UniProtKB:P16287}. Host endomembrane system {ECO:0000250|UniProtKB:P16287}; Peripheral membrane protein {ECO:0000250|UniProtKB:P16287}. Host cytoplasm {ECO:0000250|UniProtKB:P16287}.
Interaction partners:
Sequence:
MNFLRKIVKNCRDEDTQKPSPVSAPLDDDDLWLPPPEYVPLKELTSKKNMRNFCINGGVKVCSPNGYSFRILRHILKSFDEIYSGNHRMIGLVKVVIGLALSGSPVPEGMNWVYKLRRTFIFQWADSRGPLEGEELEYSQEITWDDDTEFVGLQIRVIAKQCHIQGRIWCINMNPRACQLWSDMSLQTQRSEEDKDSSLLLE
Protein: Serine/threonine-protein kinase greatwall (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (A0A0B4KGX7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MENADATSQSDVHIDYKTPKKTHSLIDSEQLLDKINILTTKPENHSQNAKLPTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQRNRISKGPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNERPAAKEVQQMRHFACIDWENIGNTEPPFVPTPDNPTDTGYFDARNNLQHLQLSNFALEE
Protein: Odorant-binding protein 1a (Odorant-binding protein IA) (Q9D3H2)
Organism: Mus musculus (Mouse)
Function: Binds the chemical odorant 2-isobutyl-3-methoxypyrazine.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Lipocalin 11
- Odorant-binding protein 1b
- Predicted gene 14743
- Prolactin-induced protein
- Exocrine gland secreted peptide 23
Sequence:
MAKFLLLALTFGLAHAAMEGPWKTVAIAADRVDKIERGGELRIYCRSLTCEKECKEMKVTFYVNENGQCSLTTITGYLQEDGKTYKTQFQGNNRYKLVDESPENLTFYSENVDRADRKTKLLFILGHGPLTSEQKEKFAELAEEKGIPAGNIREVLITDYCPE
Protein: AT15637p (Q8MSN5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHPGYCHDCGQRNGNTLEEIIHHNRTMHVKEFPFVCETCGESYSRKQQFHAHVESHNKKEIKTFPCGECGLKFPQKKLQQHFEETGHKADGAICEVCGEEFQSKNALYQHIIRVHKRDNFFECHICHNRFTLKANLERHVQLHTEIKRPYVCDLCGSSYFTYPALKEHYSNAHVDVSECKCTLCGKRFGSAKSLQRHLPSHSEERPHCCNYCDQTFKWKTHLVRHKQTMHGNEPPPPKKGKQRFPKTSEEDMGSLPDMPGPPPVKASKKAATSKAKAQAAAAAAAAASSQQQQQKGSAATPTPPPPVSTTPGCLQQDPFNAAMVSSNSSQSSTASTSQHSVSTSESQQNSIYNQSFNAEKQQPGQQQPQNALHQQHPTPPPPQQQQQQQQQQQAPPQSRVGPGELHLQRMNSFGQDGQFHFESNPAAGAYQQHQLISQYQQQQQQQQQQQQQQPQQQQQHHLAQQQQQHMRSHTPQSPHPPHPSQLQQQQPQQHFSSPHHMPPMHHQHQLMMQQQHRHNQRSPLHHHPAAQQLQQQHQQPSHSPQHQHARLQSPQPAPVQQQQQQQQQQQQQQQQFLQQQAADTWGNMNFGNPPNNQQVELKDNKFYIVESAEFLGLPMNVPPSPQQQQQQAVSKPQQQQQQQHPQPQQPDPTLAGDLMSFQHMWPAPGFSQTSQQQQPQQQQQQQAAQQQQQQQQQAQSQANSSDPHNYNNIGSILTNLIDTNPAPMEYNFDLMQQQQTPSAQQQQQQQQQQQAAQQQHHSAGAYGSGLMRSGGGVYGGAYEQHLSDQLVSEQQKQNSFQPYHPHGLQAQQQQPLHPHPHLLPPPAPHNNVYDRTGVGVGVGVGVGVGVGVGYPMLGDDTKSVLPPMMGGMMQQMPPHGQQPDLIYYPVKND
Protein: Leucine-responsive regulatory protein (Q7MBU9)
Organism: Vibrio vulnificus (strain YJ016)
Interaction partners:
Sequence:
MSGYPLDRIDLQILRILHLKGRLPVVELAKQVNLTTSPCSERVKRLEKEGYIKGYHAELNAEKLGLDVQVFIHIRLDQTSFSIFEKFAKAVADMPEIEECYSLSGDFDTMIKVRVKSMKAYQEFMSSKLGTLPGVIQTRSEVVIEEHKTGFGVNPELLSTLYQK
Protein: Piwi-like protein 4 (Q4G033)
Organism: Rattus norvegicus (Rat)
Function: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Does not show endonuclease activity. Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus. In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion. Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8CGT6}. Cytoplasm {ECO:0000250|UniProtKB:Q8CGT6}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8CGT6}.
Interaction partners:
- ATP-dependent RNA helicase TDRD9
- Tudor domain-containing protein 1
- Tudor domain-containing protein 6
- Tudor domain-containing protein 7
- Tudor and KH domain-containing protein
- RING finger protein 17
Sequence:
MSGRARVRARGITTGHSAREVERAPRDLMVTSVSPGDNEASSRTSVISQPHELGVSSGDGRRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQLYQYHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQRGETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFESKLLVNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLSLTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLSSEPLNTWLIVCCSRAEHLIESFLSCLRRVGGSTGFSVGHPKIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDCPVPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAVVGFVASINSRITRWFSRCVLQRTAADIADCLKVCMTGALNKWYKHNHDLPARIIAYRDGVGNGQLKAVLEYEVPQLLSSVTECGSDARSCRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEATRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL
Protein: Myrosinase-binding protein 1 (Jacalin-related lectin 7) (Myrosinase-binding protein-like At1g52040) (Q9SAV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GDSL esterase/lipase At1g54020
- FAD/NAD
- Protein trichome birefringence-like 26
- N-
- CAP superfamily protein
- AT4g23680/F9D16_150
- Mto 1 responding down 1
- Isovalerate--CoA ligase AAE2
- At1g79720
- Serine/threonine-protein kinase PBL34
Sequence:
MSTGGPQKLEAQGGKEGKEWDDGAEHDGVTKIYVAAGGLGIEQIRFDYVKNGQPKEGSFHGVKGRSTISTIEISHPAEYLISMEGWYDSTNIIQGIQFKSNKHTSQYFGYEFLGDGTQFSLQVNDNKIISFHGFADSHLNSVGAYFAPISSSLTTTPNKVEAQGGNGGETFDDGVFDHVRKVYVGQGESGVAYVKFEYEKDGKRETRDHGKMTLLGTEEFEVDSDDYITSIEVSVDKVFGYNSEIVTALVFKTSKGTTSPPFGMVTEKKFELKDGNGGKLAGFHGKASDVLYALGAYFAPSTTSTTPSTTKKLQARGGNGGASWDDGVFDGVRKILVGQGNDGVAFVTFEYNKGSQAILGDGHGKKTLLGTETFELDYPSEYITSVEGYYDKIFGVEAEVVTSLMFKTNKRTSQPFGMTAGEHFELKEDGYKVVGFHGKAGDLVHQIGVHIVPIFTNYRVAI
Protein: Ras-related protein Rab-1C (O76173)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- RabGAP/TBC domain-containing protein
Sequence:
MGCSPSKEGNGSFSSTSTSFIHGSESHPEYDMLLKILVIGDSGVGKSCMLLRFADNRFTDSYISTIGVDFCIRTIELDGKKIKLQIWDTAGQERFKTITTSYYRGAHGLIIVYDITSMDSFNSIKRWLIDVDRFASPSVLKLIVGNKCDLNSKRAVDFKIAKKFADELNIPIMETSAKESTAIDEAFIKLASDIKKSTPQK
Protein: HCG2044780, isoform CRA_b (Plasmanylethanolamine desaturase 1) (cDNA FLJ56328, highly similar to Homo sapiens ubiquitin-conjugating enzyme variant Kua (Kua), mRNA) (Q5TGE2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNERAIAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK
Protein: Kazachoc, isoform C (Q9W1G5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQSNSAKDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS
Protein: Cytochrome c oxidase subunit 6b-3 (AtCOX6b-3) (Q9SUD3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Cytochrome c oxidase subunit 6a, mitochondrial
- Cytochrome c oxidase subunit 5b-1, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 5b-2, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b-c1 complex subunit 7-1, mitochondrial
- Cytochrome b-c1 complex subunit 7-2, mitochondrial
- Cytochrome b-c1 complex subunit 6-1, mitochondrial
Sequence:
MEDEIELKTAPADFRFPTTNQTRHCFTRYIEFHRCTTAKGEDANECERFAKYYRALCPGEWVDKWNEQRETGTFPGPL
Protein: Transferrin receptor protein 2 (TfR2) (Q9JKX3)
Organism: Mus musculus (Mouse)
Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Subcellular location: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Interaction partners:
- Hereditary hemochromatosis protein homolog
- Hemojuvelin
- Erythropoietin receptor
- Transferrin receptor protein 1
- Transmembrane protease serine 6
- Hepcidin
- Hepcidin-2
- Bone morphogenetic protein 6
- Beta-2-microglobulin
- Ferroportin
Sequence:
MEQRWGLLRRVQQWSPRPSQTIYRRVEGPQLEHLEEEDREEGAELPAQFCPMELKGPEHLGSCPGRSIPIPWAAAGRKAAPYLVLITLLIFTGAFLLGYVAFRGSCQACGDSVLVVDEDVNPEDSGRTTLYWSDLQAMFLRFLGEGRMEDTIRLTSLRERVAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHANTLHWVDADGSVQEQLPLEDPEVYCPYSATGNATGKLVYAHYGRSEDLQDLKAKGVELAGSLLLVRVGITSFAQKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGLSSHQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVESSGLPSIPAQPISADIADQLLRKLTGPVAPQEWKGHLSGSPYRLGPGPDLRLVVNNHRVSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLGDGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDSSAYSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVQAVAQLAGQLLIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKERGLTLQWVYSARGDYIRAAEKLRKEIYSSERNDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALVDHLRMLRADGSGAASSRLTAGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF