wanglab/gogpt-training-data huggingface dataset:
Protein: Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) (Q14554)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- X-box-binding protein 1
- Cyclic AMP-dependent transcription factor ATF-6 alpha
Sequence:
MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAAENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL
Protein: Sorbose reductase SOU1 (EC 1.1.1.289) (Sorbitol utilization protein SOU1) (P87219)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the NADP dependent reduction of L-sorbose to D-glucitol. Can also convert fructose to mannitol, but less efficiently.
Interaction partners:
- Uncharacterized protein
- Sorbose reductase homolog SOU2
- ESCRT-II subunit protein
Sequence:
MSEEIISFTNPALGPLPTKAPQLPSNVLDLFSLKGKVASVTGSSGGIGWAVAEAFAQAGADVAIWYNSKPADAKAEYLTEKYGVKAKAYKCNVTDPNDVSKVINEIEKDFGTIDIFVANAGVAWTDGPEIDVQGYDQWKKIVDCDLNGVYYCAHTVGQIFKKNKSGSLIITSSMSGTIVNIPQLQAPYNAAKAACTHLAKSLSVEWASFGARVNSISPGYILTDIADFADPEMKKKWWQLTPLGREGLPQELVGAYLYLASNASTYTTGSNIAVDGGYTCP
Protein: Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) (Q9HCX4)
Organism: Homo sapiens (Human)
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21402151}; Multi-pass membrane protein {ECO:0000269|PubMed:21402151}. Nucleus envelope {ECO:0000269|PubMed:21402151}.
Interaction partners:
- Protachykinin-1
- Short transient receptor potential channel 3
- Short transient receptor potential channel 4
- Thioredoxin domain-containing protein 17
- Progonadoliberin-2
Sequence:
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
Protein: Motile sperm domain-containing protein 1 (Q9UJG1)
Organism: Homo sapiens (Human)
Function: Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8VEL0}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8VEL0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Motile sperm domain-containing protein 2
Sequence:
MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVVATLLPSAKEQQKEEEEKRLKEHLTESLFFEQSFQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDVESLVPLYLHLSVNQKLVAAYILGLITMAILRT
Protein: Insulin-like growth factor-binding protein 1 (Q8JHX6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin
- Insulin
- Insulin-like growth factor 2a.
Sequence:
MNRLLLNFFWVAAFSALLAAPGLRASPVVGQEPIRCAPCSPERLAECPAVDAGCEEVLREPGCGCCLACALKRGDPCGIYTAPCGSGLRCLPKPGEARPLHALTRGQAVCTESPEPNHSQSETAPDHPESHNGPTAVNEGSSTVFVTGHGKPFDPRIITNKESMKAKVNAIRKKLVEQGPCHIELQTALDKITKSQQKLGDKLTRFYLPNCDKHGLYKIKQCESSLDGQRGKCWCVSSWNGKKIPGSSDLPADAECPEELNH
Protein: DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) (Q9CX47)
Organism: Mus musculus (Mouse)
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein RAD51 homolog 4
- DNA repair protein RAD51 homolog 3
- DNA repair protein RAD51 homolog 2
- DNA repair protein XRCC3
- Breast cancer type 2 susceptibility protein homolog
- DNA repair protein RAD51 homolog 1
- Breast cancer type 1 susceptibility protein homolog
- Double-strand break repair protein MRE11
- Fanconi anemia group J protein homolog
- Partner and localizer of BRCA2
Sequence:
MCSDFRRAESGTELLARLEGRSSLKELEPNLFADEDSPVHGDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQSSEEAMKLCLARLFLAYCSSSMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVSGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQSLMQKGSDSADGPSSSKHPCDGDMGYRAYLCKAWQRVVKHRVIFSRDDEAKSSRFSLVSRHLKSNSLKKHSFMVRESGVEFC
Protein: Mitochondrial import receptor subunit tom20 (Mitochondrial 20 kDa outer membrane protein) (Translocase of outer membrane 20 kDa subunit) (O14225)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial import receptor subunit tom22
- Probable mitochondrial import receptor subunit tom40
- Probable mitochondrial import receptor subunit tom70
- Mitochondrial import receptor subunit tom7
- SAM50-like protein SPAC17C9.06
- Metaxin-1
- Mitochondrial Rho GTPase 1
- Metaxin-like protein C409.19c
- Mitochondrial distribution and morphology protein 10
- Calnexin homolog
Sequence:
MRRSVIIGSLLATAAVGYAIYFDYKRRNDPHFRKTLKRRYKKVHEAKKQEEKLATKKFDITVEEALQVVASTPVPSSAEEKELFFMQQVARGEQLFQQQPDNIKESAACFYSALKVYPQPVELFAIYERTVPEPIMNLLRAMQAKESIPSVE
Protein: Uncharacterized protein (Q583X3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNARDELVEQLSIALSDIEQLQPCTDTALDAELLGAVADYIESGVNAEATLKRLRGTLAQVAKKGSVPQAPVQVKKESEGEEKEMNGNGAVSAPVLTAEELGRQRAQLILRDILKERYARH
Protein: Uncharacterized protein C18G6.09c (Q10108)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- mRNA decapping complex subunit 2
- mRNA-decapping enzyme subunit 1
- LSM1-LSM7 complex subunit lsm1
- Uncharacterized protein C167.05
- Putative ATP-dependent RNA helicase ste13
- Nuclear cap-binding protein subunit 2
- Nuclear cap-binding protein subunit 1
- Uncharacterized protein C16C4.16c
Sequence:
MQKDIGRRFQRNKKKINSKPGGAMVASSDVEFSLDGMSIMPQRDGNLQIPNFVKPKSTFATSNIGESNGKRNGDKVRGNRRSKSGHSSYAGSRISGGNSNSHLPSGVASAPAGLGIDKVAVGEVDSHLKSVSSYVSNSSGADRSFSSNSSSDTNSILYAGPTFTHSPAASNLPIPTFLHSPVSEKAEWQPPTGSVNSNMPFQFHQSSSVPSTPSEVAMGHNFCPMSRNDPSLQSIQQTNGFYSGHNSPHTNYSASTPSFNHFNAAGHPTGNITPTLNSPNNGIHCHSTSALDLLFHRDREQRLFRMLRQGSA
Protein: HCG18989, isoform CRA_h (MLX interacting protein like) (A0A0C4DG26)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSDSLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIELPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPST
Protein: T-complex protein 1 subunit delta (Q38CD4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- CCT-theta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit eta
- T-complex protein 1, zeta subunit, putative
- T-complex protein 1 subunit epsilon
- CCT-beta
- Peroxin 19
- Phosducin domain-containing protein
- Prefoldin, putative
Sequence:
MSTKKANENKKDTNTQTDVRLSNITSAKAVADCIRTSLGPRGMDKMIIEPRGEVIISNDGATILSKLQVTHPCAKMLVELSKAQDVEAGDGTTSVVVLCGALLRAVEELLLKGIHPTQISECFNECAKLAEQVLEGMSVKIDINDRETLIRAAITSLNSKIISQNSDLIAPMAVDAVRQIMRDNGDVDLRDVRIVTALGGTIDESVMLSNGMVFKQKASHVAGGPVRIANATIALIQFQLSPPKTDMESTVTISDYNQMDRALKEERKYLLNLCKQIKDAGVNVLLVQKSVLRDAVTVQSLDFLAKMKIMVVKDVERSDIDFITKTIGCLPVANIENLKPEKFGHADLVVEENTPSGKIIRITGVQPPSEKINLQLFGKTVTFFLRGSNNLMLEEAERALHDSLCVIRSIVKKRAIVAGGAAGETEVCLQLSKYARERAQGMQTFCMRAFADAFEVVPYTLAENAGLQPISIVTELRNAHASGNKNAGVNVRKGCVTDMVEENVVQPLLVSTSAVRLAAECVMMILKIDDIIMTRA
Protein: Spliceosomal protein (Q24534)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAGPIAERNQDATIYAGGLDDKVSETLLWELFVQAGPVGKSGHTCIVPSSSLIVMLAVNVHMPKDRVTQMHQGYGFVEFLSEEDADYGIKIMNMIKLYGKPIRVNKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQTPKIMRDPETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRPISVSYAFKKDHKGERHGSAAERLLAAQNPSTHADRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMPPPMMAPPPPVVPVSNNNMGMLAPPPPVPQPAPFPATIPPPPLPPMTGGQPPLPPAMGIPPPPRMMQPNAWAPPGMPAPPPRPPPTNWRPPPVPFPPTPYARPYQPDGYQY
Protein: Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) (Q2VP86)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MEVQLGVGRVYPRPAGRTFRGAFQSFFQSVCDAFQPPREEQGAGQPPPSAPCPPSPRAPPDSPACLLPPPGCLPPPEPRAPGKALPAAGPAMGSSFPCAGELRELLGEAAAIPMLPPPESEPADKEDPLGDSARQLCRAVSASMGLALEALETPAEQLPREDCMFAVPAGPPRAPRPPARDSSPAFEAVLAAEPPAGPGLPRGFGRVKLESAAGPATGGGWGGPCRFGAELVPPGPAPPWPTFFAEEGQLYGPCPEPPAGPADCPADAWYPPGRAPFAAPAPGIKSELQPWVEGYAGAYGDLRLETGREHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKAQDDMEGASSSSPTEEQTPKLVMTRIDGYECQPIFLNVLEAIEPGVVCAGHDNSQPDSFSNLLSSLNELGERQLVYVVKWAKALPGFRNLHVDDQMSIIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCIRMRHLSQEFGWLQITPQEFLCMKALLFFSIIPVDGLKNQKLFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKVLDSVHPIAKDLHQFTFDLLIKAHMVSVDYPEMMAEIISVQVPKILSGKVKPIYFHAQ
Protein: Olfactory receptor (Q8VG50)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MDTKNISFITEFILVGLTEYTETHFPFFFLFLGIYAITVAGNLGLLTLIGMNSPLHTPMYYFLFNLSFIDLCYSTVITPKLLVNFVSERNTISYEGCMTQLYFYCFFVSAECYVLTVMAYDRYVAICKPLLYTVTMSPQVCSLLTLIVYVGAFIGAWAHTGCMMRLTFCKDNTVNHYMCDILPLLELSCSSTYINELVVFIVVGFDVGVPSITIVVSYTFILSSILHIRSTEGRSKAFSTCSSHIIVVSVFFGSGAFMYLHPSSVLSMDQGKVSTVFYTIVVPMLNPLIYSFRNKEVKIALRKTLRMKISS
Protein: Peptidyl-prolyl cis-trans isomerase 8 (PPIase 8) (EC 5.2.1.8) (Cyclophilin-8) (CYP-8) (Rotamase 8) (P52016)
Organism: Caenorhabditis elegans
Function: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May play a role in the protein folding, transport and assembly.
Interaction partners:
- Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein
- DnaJ homolog subfamily B member 13
- Stress-induced-phosphoprotein 1
- Co-chaperone protein daf-41
- Histidine kinase/HSP90-like ATPase domain-containing protein
- Heat shock protein 90
- Nsp1_C domain-containing protein
- Tetratricopeptide repeat protein 7B
Sequence:
MPPEVRGNKRAFFDISINGEPAGRIVFSLWNHCCPRTVENFRAFCTGELGKMNGHYASYQGSVFHRVIKGFMIQGGDITHGNGTGGYSIYGRTFDDENLALKHKKPYLLSMANRGPDTNGSQFFITSEEVPHLDGKHCVFGEVIKGVEVVKAIENLETGNEDKPVCKVEITHCGEMVRKGDVVGNAGAAASEPEPTGVKMEDEPKTRNWLMRYSKSPESREEKKKDKHGREEKRDRRRRSNDRHGRDRRSRSRSQSRDRNRRRDDRSGRDGRVGRNERDDRSGRDERRDDRRSAPTKDGIKVRGRGKLTFLGGRTRSTTPPHWKREESKKLTLEAHQKRQEELEERQKRAAQREKEEAERNARLEKERVERQNQRELERQKQEAERELKRQQENEESGNRRRRRSSRSGSENDESELEEPKNRSASPRKRSSSSSSSSSSGHSSDSD
Protein: Protein CHLORORESPIRATORY REDUCTION 41, chloroplastic (Q9C685)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. Functions in assembly or stabilization of the NDH complex; probably involved, together with NdhO and NdhH, in the formation of an NDH subcomplex A assembly intermediate (NAI500).
Subcellular location: Plastid, chloroplast {ECO:0000255}. Plastid, chloroplast stroma {ECO:0000269|PubMed:22274627}.
Interaction partners:
- Protein CHLORORESPIRATORY REDUCTION 42
- Protein CHLORORESPIRATORY REDUCTION 6
- Protein CHLORORESPIRATORY REDUCTION 7
- NAD
- NAD
- NAD
Sequence:
MASTSTLLLPSLSSKNLHIAVPIRTNSFVRRTTKFSTKCSSNPESKDQFINLTPAPESINTTSAEKFPIEKRRRSEIIRDRTQRGIEKPEPPNFEIGWKRTKEINLEKPKGYVIMDFLEKFEALMAREFGSKELLAKAGEIVAERAREEAEVLRDEGKVEERMVTELFRVLKLMEMDLAMVKASVKDETLSQRIEQARARCRQAILVANSF
Protein: Mu-conotoxin SrVA (Conotoxin sr5a) (Sr5.1) (Sr5.2) (Sr5.3) (P84845)
Organism: Conus spurius (Alphabet cone)
Function: When injected intracranially into 9-day-old mice, causes transient symptoms, including extension of the body and clockwise and counter-clockwise turns, that last 3 to 4 minutes. When injected intracranially into 16-day-old mice, causes transient symptoms, including agitated breathing and occasional turning followed by scratching and grooming behavior, that last for 15-19 minutes.
Subcellular location: Secreted {ECO:0000269|PubMed:16297502}.
Interaction partners:
Sequence:
MRCLPVFVILLLLIASAPSVDAQLKTKDDVPLASFHDNAKGTQHKRIINWCCLIFYQCC
Protein: Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha) (P29992)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Together with GNAQ, required for heart development (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:18703424}; Lipid-anchor {ECO:0000305|PubMed:18703424}. Cytoplasm {ECO:0000269|PubMed:18703424}. Note=In testicular cells, expressed exclusively in the cytoplasm. {ECO:0000269|PubMed:18703424}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Extracellular calcium-sensing receptor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
- Guanine nucleotide-binding protein G
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- Endothelin receptor type B
- Alpha-1A adrenergic receptor
- Alpha-1D adrenergic receptor
- Endothelin-1 receptor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Sequence:
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Protein: Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (Q388D3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosomal protein L37
- 40S ribosomal protein S5, putative
- 60S ribosomal subunit protein L31, putative
- 40S ribosomal protein S4
- Protein LTV1 homolog
- 60S ribosomal protein L35A, putative
- Elongation initiation factor 2 alpha subunit, putative
- 40S ribosomal protein S27, putative
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein uS4
Sequence:
MADAPRGTGGEQRGFGRGRGGRGGRGGRGGRGGRGGGGDEKEWVPCTKLGRLVKDQKITSLEEIFLFSMPIKEHQIVDQLIREGDLRDEMMLVFPVQKATSAGQRTRFKAFNVVGDGNGHIGVGARVGKEVSLAIRASMIAAKLSIVPVRRGYWGNKIGEPHTIPIKVTGKCGSVAVRLIPAPRGAGIVAAPVPKKILEFAGVEDVYTSSCGKTRTRGNFIMATFYALRKTYGFLTPDLWAETEVSRDPTDEHSEFLSMGRKMVAA
Protein: Toll-like receptor Tollo (Toll-like receptor 8) (Q9V477)
Organism: Drosophila melanogaster (Fruit fly)
Function: Toll-related receptor. Probably specific to larval innate immunity. Involved in the tracheal immune response of larvae to Gram-negative and perhaps Gram-positive bacteria; upon infection it negatively regulates the immune deficiency (Imd) signaling cascade specifically in the respiratory epithelium to prevent the overexpression of antimicrobial peptides (AMP). Involved in the NF-kappa-B-dependent apoptosis of unfit cells during cell competition. Involved in neuron-specific glycosylation. Positively controls the neuromuscular junction (NMJ) growth in presynaptic motorneurons, probably via the JNK pathway. During development of the peripheral nervous system, may function in the NF-kappa-B (rel) regulatory cascade to repress expression of the neuron-specific genes sc and ase in non-neuronal cells. Promotes heterophilic cell adhesion with 18w in vitro. May have a minor role in leg development. May be involved in determining the proximal cell fate in the wing, possibly by negatively regulating the Dpp signaling pathway.. May also be involved in the Dpp signaling pathway in the eye. Possibly functions with 18w and Toll-6 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22022271}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:22022271}. Note=In larvae, localizes to the apical cell membrane in trachea epithelial cells. {ECO:0000269|PubMed:22022271}.
Interaction partners:
- Protein spaetzle 3
- Latrophilin Cirl
- Neurotrophin 1
- LD20892p
Sequence:
MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINSELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQQAMPLPHSVHHHQQQFMLPPPPQQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQAALLMGGGSVGGPAPQMIPLAGGIQQQSLPLPPNQQPTPASRNLHM
Protein: Platelet-derived growth factor subunit A (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) (Q90WK1)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRTWACVLLIGFGYLSFTSCEEAEIPQELIERLAHSEIHSIRDLQRLLEIDSVGYDDVSETNLRSYSVHSAKHVQENRPVPIRRKRSIEEAIPAVCKTRTVIYEIPRSQIDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRIHHRSVKVAKVEYVRKKPKLKEVLVRLEEHMECTCTSTNTNSDYREEETD
Protein: Transcription initiation factor TFIID subunit 5 (TBP-associated factor 5) (AtTAF5) (Q6S7B0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 4
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 4b
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 6b
- Transcription initiation factor TFIID subunit 1
Sequence:
MDPEQINEFVVGYLKKKGFSSAAKDLESYHHQNNNGSSFTSVDYHNDPELTKLIRSFSQQEDDPTRYREGYSKLRSWAYNSLDLYKHELLRVMYPVFIHCYMDLVGKGHTQEARAFFNSFRKDHEMVHLRDLQKLEGVLSPSHLEEMEFARSLRKSKVNIKFCQYSYELLLQYLHSTVSTLMLGIINEHINFQVYSGQPTSSSDDIEAVTIVGSFQDTANHINQKEIQWGLLEDSLEDRLEKTGGLLSDSEKGQGESKDGDADDSKKRSTEIGKQGSSLKKLKKDKAGNATAKVARLETITVSPAPRVKPELALPVMSTDVEQSILEDLRNRVQLSSVAMPSVSFYTFVNTHNGLNCSSISHDGSLVAGGFSDSSIKVWDMAKIGQAGSGALQAENDSSDQSIGPNGRRSYTLLLGHSGPVYSATFSPPGDFVLSSSADTTIRLWSTKLNANLVCYKGHNYPVWDAQFSPFGHYFASCSHDRTARIWSMDRIQPLRIMAGHLSDVDCVQWHPNCNYIATGSSDKTVRLWDVQTGECVRIFIGHRSMVLSLAMSPDGRYMASGDEDGTIMMWDLSTARCITPLMGHNSCVWSLSYSGEGSLLASGSADCTVKLWDVTSSTKLTKAEEKNGNSNRLRSLRTFPTKSTPVHALRFSRRNLLFAAGAISKPAN
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (A0A8I6AVW5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038126}.
Interaction partners:
Sequence:
MHPRCLNWKYMSLEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW