wanglab/gogpt-training-data huggingface dataset:
Protein: P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) (Q9Z1M0)
Organism: Mus musculus (Mouse)
Function: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q99572}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64663}.
Interaction partners:
- Pannexin-1
- P2X purinoceptor 1
- P2X purinoceptor 2
- P2X purinoceptor 3
- P2X purinoceptor 6
- Glutamate receptor ionotropic, NMDA 1
- Neuronal acetylcholine receptor subunit alpha-7
- Caspase-1
- Glutamate receptor ionotropic, NMDA 2A
- NACHT, LRR and PYD domains-containing protein 3
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (Q2LIN9)
Organism: Oryza meyeriana var. granulata
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
RVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRDASICVKGPRYITAQDIILPPSVEIVDMAQPIANLTEPMDFRIELRIKRDRGYHTEVRKNAQDGSYPIDAVSMPVRNVNYSIFSCGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENKNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKYLPMDLPKNKL
Protein: Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (CD antigen CD213a2) (Q8VHK6)
Organism: Rattus norvegicus (Rat)
Function: Binds as a monomer with high affinity to interleukin-13 (IL13).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14627}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q14627}.
Interaction partners:
- Interleukin-13
- Interleukin-4 receptor subunit alpha
- Interleukin-4
- Interleukin-6
- Interferon gamma
- Interleukin-5
- Tmem219 protein
- Tyrosine-protein kinase
- Cytosolic non-specific dipeptidase
- Interleukin-10
Sequence:
MALMAVNTRCLCLFLLCTITGHSLEIKVNPPQDFEILDPGLLGYLYLQWKPPVVMDNFKECKLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWTEASYGIADEGSLGTKIQDMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVGCKLSNLDSSDYKDFFIRVNGSSKLEPIRSSYMVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPSCYTYEIVVREDDISWESATDKNDMKLKRRANESEDLCFFVRCKINIYCADDGIWSEWSEEECWEGYTGPDSKIVFIVPVCLFFIFLLLLLCLIVEKEDPEPTLSLHVDLNKEMYAYEETLC
Protein: Altered inheritance of mitochondria protein 26, mitochondrial (P32858)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in selective mitochondria autophagy (mitophagy).
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:19793921}; Multi-pass membrane protein {ECO:0000269|PubMed:19793921}.
Interaction partners:
- Putative uncharacterized protein YGL072C
- Uncharacterized protein YGL235W
Sequence:
MQTMGGEHLLLSQLKGSFFLLLLAYFFRGRSPYYARCYRRLAVTPGAITIAIAIATDSIPALAKSKVLVSVCSHTDPCTASCNLIPFPRPFSNSLTRFLFCLGSARFCISFPCFGLSI
Protein: Lysozyme A (EC 3.2.1.n3) (1,4-beta-N-acetylmuramidase A) (Q8T1G4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Has antibacterial activity against the Gram-positive bacteria B.subtilis, B.megaterium and M.luteus. No antibacterial activity detected against the Gram-positive bacterium S.aureus or against the Gram-negative bacterium E.coli. Lacks chitinase activity.
Subcellular location: Cytoplasmic vesicle lumen {ECO:0000269|PubMed:15640146}.
Interaction partners:
- Membrane-associated sulfotransferase kil1
Sequence:
MRIAFFLLVLAVIIGFAYGYSCPKPCYGNMCCSTSPNNQYYLTDFCGSTSACGPVPSCSGALYFTADSQRFGCGKYLNLCRSGKCVKAQIYDAGPAMWVEQDAGMMIIDASPTICHVLTGGSSCGWSDHFLITATVTSLTDSRPLGPFNVTESEMAQLFIDHEIAMAQCEAEKTCNGFDLE
Protein: MIP07271p (D0IQG6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDWPDCPPRPLRVKIFQIQLKALHCTDYNHEVQPPEPNSLGTKVRQKTKAQQQQQQQQHTLQETRSYCTSEPRLSETETPPQRRKLSQRRPQTHAHRKSNAFLDVPTMNMHHLRVNDDDEDVDRLRTFSASKGGIINRGDSFRRRRSRSNSLAPSSPMHTRNGVGGLGGVAGGGSSLGLGCGYNGGSSSNGFGNANAQENHQPVEFYRVEMLGSAGVGKQALLSQFRTSDCINAYDGPECDDAEQNVSIILNGTESELKFLTGNPESKDELEQADAFLVVYSCIDKESFTRAKQILSRLQDMDLLRHRPTILVANKIDLARSRAVSAQDGKCVACTFGAKFIEVSVGINHNCDELLAGTLTQIRLKKDQVQLQGPRDANSPAHWYKSRSVMLASMKARQMLTWILGKEDSKFKHCENLQVL
Protein: Swarming motility protein SwrAA (O32266)
Organism: Bacillus subtilis (strain 168)
Function: Required for swarm cell differentiation. Plays a crucial role in regulating the degree of cell flagellation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16030230}.
Interaction partners:
Sequence:
MKRASIVREKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTNVESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLSNVTLWMTQER
Protein: Uncharacterized protein C19A8.11c (O13827)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein F
- LSM complex subunit lsm7
- LSM complex subunit lsm4
- U1 small nuclear ribonucleoprotein C
- LSM2-LSM8 complex subunit lsm8
- LSM complex subunit lsm3
Sequence:
MRVILVIGRSNSGKLDFIKALTGSLPKGLDDEAFNNDHSGLIHKYNIRNKYFEASVGIWIEEYSNLAETLDAYSSEEAKEVIDSLGAIVYTFRSFDEAEWSLFKNFIDKLQLEIPVIGLHMSDEKLLEPPDVFTPEYISISEEGVNEFNEKVGLDRVREILDCCEWNLSQVDKSFSEEKDDAGDFYLPERFKGSPDMQSTDLDNLMKEMNQIRDADLEKNEKKAKALNLLEKLLGDEFEENDYESL
Protein: Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) (G8BB94)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Transketolase
- Transaldolase
- phosphopyruvate hydratase
- phosphopyruvate hydratase
- Uncharacterized protein
- Glucose-6-phosphate 1-dehydrogenase
Sequence:
MAIKVGINGFGRIGRLVLRIALQRKDIEVVAVNDPFIAPDYAAYMFKYDSTHRTYKGDVKSEGDTLIIDGHKIKVHGEKDPASIPWGKDGVDYVIESTGVFTTLEGAHKHIEGGAKKVVITAPSKDAPMFVVGVNDDKLNKEDEIISNASCTTNCLAPLAKVINDKFGIEDGLMTTVHSMTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVIPELNGKLTGMSLRVPTVDVSVVDLTVNLKKSTSYEEISKVIQEAANGPLKGILGYTDDAVVSTDFLGSSYSSIFDDKAGILLTPTFVKLIAWYDNEYGYSTRVVDLLEKFAKVNGN
Protein: Nuclear hormone receptor family member nhr-69 (P91829)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor which, in cooperation with R-SMAD daf-8, modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of insulin-like peptide daf-28.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:22359515}.
Interaction partners:
- Smad protein daf-8
Sequence:
MVEEICHICNDKSTGKHYGAISCDGCKGFFRRSIRKRYHYQCRFEQNCDVTKNKRNACRACRLQKCVKAGMKSNAIQNERDAIGKRKKTTGAEKEDLIDQLVAAETLCQQLRSSVIKNTSSLAPYDCGKVKWNYEDARAATLDDIGKSIHQQLVLFIEWAKSLPQFSFLAQADQAALLKGGAASIIVLGVAYRSICLTVENTICLANDTLLPKEHATQVGDINCVVGRIIDEIVNPMRRLNMDLIEYVALKAILFFNPVVREINDQSPVENARYAFLRSLQRRCTDKALENMEDESMDCRSGKLLLLLPSLQAIAQQLVEDVQLARLFGLVNVDSLMEELILNDMKPSDPQILQTSLASPVNSSVKAEVELEE
Protein: Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) (Protein maroon-like) (Ma-l) (Q9VRA2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Interaction partners:
- Iron-sulfur cluster assembly enzyme IscU
- Molybdenum cofactor synthesis protein cinnamon
- Molybdenum cofactor biosynthesis protein 1
- Sulfite oxidase, mitochondrial
- Carboxylic ester hydrolase
- Xanthine dehydrogenase
- Molybdopterin synthase catalytic subunit
- Uncharacterized protein, isoform B
Sequence:
MTSYRPEFSASEQSQIDAEFSRLASNKSVYLDHAGTTLYAESQVTAAAEQLQRNVICNPHTCRLTGDFVDQVRFKILEFFNTTAEDYHVIFTANATAALSLVAENFDFGSSGEFHFCQENHTSVLGMRERVRENGIYMLRENEISGGKHKANGKVHEVSGKTGNSLLTFSAQCNFSGYKIPLEVIEQIQIDGLAKPGKELWSSLGEKKKNMHNDYYICLDAASFVATSPLDLQKYRPDYVCLSFYKIFGYPTGVGALLVSRRGAEVFQKRRFFGGGTINYAYPHAMDYQLRETFHQRYEDGTLPFLSIVGLLEGFRTLERLVPRTDEFSTMERISRHVFGLAKYLEDQLRQLHHPNGEPLVKLYNKVGYQDKSRQGGIVAFNVRTESGSFVGFGEIACVAALHGILLRTGCFCNIGACQYYLGLDEDALDAIYKRAGRICGDYFDLIDGQPTGAVRVSFGYMTTIQDVDKLLQMLRSSYLATKPLQRIQFIEEQAEQLPPLLKERVQLLRPKLLQMAIYPVKSCAAFKIELPGSWPLTDQGLKYDREWMIVDMNGMALTQKRCTELCLIRPVIKVDQLELQFGENSTISVPLSLDDQAADTAKCVSKVCRQPVEGLDCGDRVAQWLSENLGMEGLRLLRQSGQRNSSKDQQKLSLVNQAQFLLLNKSSVRSLQFEEPLDETVDRFRANIIIDTGSAFEELTYKALSIGGIQFQVEGPCQRCDMICINQRTGERSPETLTTISRLQKGRMRFGIYITRIPQDTKELEPKEQHMTCGDVVLVE
Protein: Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) (P55201)
Organism: Homo sapiens (Human)
Function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation. Positively regulates the transcription of RUNX1 and RUNX2.
Subcellular location: Nucleus {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27939640}. Chromosome {ECO:0000269|PubMed:24065767}. Cytoplasm {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:27939640}. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6 (PubMed:18794358, PubMed:27939640). Localizes to transcription start sites (PubMed:24065767). {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}.
Interaction partners:
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein 5
- Histone acetyltransferase KAT6A
- Histone acetyltransferase KAT6B
- Histone acetyltransferase KAT7
- Histone H3.2
- Histone H3.1
- Histone H3-7
- Histone H3.1t
- Bromodomain and PHD finger-containing protein 3
Sequence:
MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSSRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQSSETSDSD
Protein: C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)] (Q16627)
Organism: Homo sapiens (Human)
Function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Subcellular location: Secreted.
Interaction partners:
- Eotaxin
- C-C motif chemokine 22
- C-C chemokine receptor type 1
- C-C chemokine receptor type 5
- C-C chemokine receptor type 2
- C-C chemokine receptor type 3
- Atypical chemokine receptor 2
Sequence:
MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN
Protein: Homeobox protein dve-1 (Defective proventriculus homolog protein) (Q86MI0)
Organism: Caenorhabditis elegans
Function: Transcription factor. Acts during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Required during mitochondrial stress for the activation of genes involved in the mtUPR, in concert with histone deacetylase hda-1. In response to the citrate-induced mtUPR, positively regulates transcription of transcription factor nhr-80, thereby leading to modulation of lipid metabolism. May play a role in modulating the decline in protein homeostasis associated with normal aging. Required for embryonic development and maintenance of mitochondrial morphology.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:17925224, ECO:0000269|PubMed:32789178, ECO:0000269|PubMed:32934238}. Cytoplasm, cytosol {ECO:0000269|PubMed:30642431}. Note=Upon mitochondrial stress translocates from cytosol into the nucleus. {ECO:0000269|PubMed:30642431, ECO:0000269|PubMed:32789178}.
Interaction partners:
- Ubiquitin-like protein 5
- Stress activated transcription factor atfs-1
- Transcription factor atf-4 homolog
- Ubiquitin-like protein
- ATP-dependent Clp protease proteolytic subunit 1, mitochondrial
- LIN-65L
- HAlF transporter
- Lysine-specific demethylase jmjd-3.1
- Lysine-specific demethylase 7 homolog
- AFG3-like protein spg-7
Sequence:
MFPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHSSMSTSARGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKILSKPSTDSNSVQCISEVKNKLLKAAVNKNPNVLTNVDNQQVKDVINTIIAGDETLLNSEQIGAVNEWLDTLETNEDRRSPTQVQRFNTLYEIPRLDKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSVFSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV
Protein: Trailer hitch, isoform I (M9PFG3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYILFRGSDIKDIRVVNNHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVPSQQPPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFGNLGGPNLANMVGNAGGSLAPGSGAPGSGPFMHIGGNQQQPKPQQQKQPISVLDMLAGASRSTTPISLIVSPTAELTQQQQLHQQQNAGQGGNGRDAGHKRQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSGRQMDNNYSNNYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMMNMRNRGMGSRGPMRPNQGYRPQSANNQNKPRNKIKFEGDFDFEQANNKFEELRSQLAKLKVAEDGAPKPATNATAATATATNEQLNGETDKKDDSGNETGAGEHEPEEDDVAVCYDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSSTRRGSSYRGRNQYYNNNGNGGINSGYGGAPGYNRNNYRMGGGGGNFRNRSNNRNNGGGRGGNGMPNITNGNTAAALKAANNAAGHGSNATDSSAPNATTATTKSTSLLPEQTQQVAAVSQ
Protein: Protein sprouty homolog 2 (Q4VBS7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
METRTQNGGSGSSGLLRALRDSGRPQTGDSEPWDGQVLSLDQIRTIRGSNEYTEGPTVAPRPPASEQKTDSQASSPTSTSSIELPEHRNSLRAQQAGQQTPQQAPRGGVSRSISGTSDGSHSTTRASTGSTSSDQRLLGNAGDRVVRAQPKRSEQKQEELKPLSAPVGPAPDGKHSILCEDCGRCKCEGCTCPRTLPSCWMCGRRCVCSATSAMDYVTCVCCVKCLFYHCSSDDEDVCADKPFSCTQSHCCMRWSAISVLALFLPCLLCYLPAKGCVALCQACYDCTSRPGCRCKNKGVEK
Protein: Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) (P05187)
Organism: Homo sapiens (Human)
Function: Alkaline phosphatase that can hydrolyze various phosphate compounds.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1730777, ECO:0000269|PubMed:2153284}.
Interaction partners:
- Cancer-related nucleoside-triphosphatase
- 6-pyruvoyl tetrahydrobiopterin synthase
- Thiamine pyrophosphokinase 1
- GTP cyclohydrolase 1
- Alkaline phosphatase, germ cell type
- Paired box protein Pax-3
- Ubiquitin carboxyl-terminal hydrolase 49
- Thyroid receptor-interacting protein 11
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
Protein: Rop guanine nucleotide exchange factor 10 (AtRopGEF10) (Rho of plants guanine nucleotide exchange factor 10) (Q1KS66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP.
Interaction partners:
- Putative F-box protein PP2-B6
- Putative U-box domain-containing protein 50
- Jacalin-related lectin 12
- Rac-like GTP-binding protein ARAC10
- Receptor like protein 24
- Transmembrane protein
- Rac-like GTP-binding protein ARAC4
- Zinc finger protein BRUTUS-like At1g74770
- Protein RALF-like 1
- Amino acid transporter AVT6B
Sequence:
MFDGRNSGHSSFSSRGDGMHTPEHELAGHAAPSTRRGKQNRRSDMEVMKERFAKLLLGEDMSGGGTGETSALALSNAITKLADSMFGEQMKLQPMYPETKENWRKEMGWLLSVIDHIVQFVPSRQMGKNGQFTEIMVTKQRDDLLTNIPALRKLDSVLLETLDNFKDQKDFWYVPRDMEDADHNGDWRRDENWWLPVVKVPTDGLSEESRRWLQNQKDSVAQVLKAATAINAHVLSEMHVPENYIDSLPKNGKTSLGDFLYKSITEESFDPDYFVSFLDLSTEHKVLDLKNRIEASMVIWKRKMCQKEKDGKSQWGSTVSLEKRELFEVRAETILVMLKQQFPGIPQSSLEVSKIKNNKDVGQAILESYSRVLESLASKIMSRIEDVLEADRLVQRQLMGEAETRSESEAESEYEETEKVVAAETPNSRKLSDFIGWRLSSDTKKHSSMSDIEFFHKVEQEKEKPMMKSPRALPKKFSYLAKLENMRSPSDRH
Protein: Preferentially expressed antigen in melanoma-like protein 7 (Prame-like 7) (Q810Y8)
Organism: Mus musculus (Mouse)
Function: Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3. Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst.
Interaction partners:
- PRAME like 6
- PRAME like 5
- Preferentially expressed antigen in melanoma-like protein 1
- Oogenesin-2
- Oog4 protein
- Oogenesin-3
- PRAME like 13
- Oogenesin-1
- PRAME like 38
- PRAME like 15
Sequence:
MVSAPPTLQDQAFRSLVRNEVLTVSDAECLIREFFPPLFKEASTQKKPKTIMILVEHWPYPCLHVGLLIDKPNFQIFQAILDGVDTWLKRKYRPRMGRLKKVDFRDAQHHASLDMQDEREGRDYLVGTLPKKQIVEDHSRTRKERLKLFHDLSFMSSLHEDKHQTLLLEWAKERTSFLHLCCEKLEIGAVEVSKVRNVLKFLQPELIKELKLNTVGNLSKLAKFVPFIRKMRNLQKLMLVRTFGTRTFTQEEKQNISKIISLFCKLSCLRHLTIDDVYFLTDQMKELLRCLEAPLVSLKITLCQLSQSDLESFAQRWNYSQLKHLCLRGVTLTNLDVTPLRDFLKRVAANLQTLDLEDCRMDDSHFRTLLPALIKCTQLTSINLYDNDISEDVLENFLHRTTNLSQLTTEMYPAPSEVYNESNYVIVEIFIQICSELMNKLMEVRQANSVCFGSSSCYDCDNRYLYEDDGDVTLCLCQE
Protein: Isoamylase 2, chloroplastic (AtISA2) (Protein DEBRANCHING ENZYME 1) (Q8L735)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the trimming of pre-amylopectin chains. Accelerates the crystallization of nascent amylopectin molecules during starch synthesis. ISA1 and ISA2 work exclusively together as a multimeric holoenzyme. ISA1-ISA2 removes preferentially branches that are very close to other branches.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18431481}.
Interaction partners:
- Alpha-glucan phosphorylase 2, cytosolic
- Alpha-glucan phosphorylase 1
- 4-alpha-glucanotransferase DPE2
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- Alpha-amylase 3, chloroplastic
- Probable alpha-amylase 2
- Alpha-amylase 1
- 1,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic
- Starch synthase 3, chloroplastic/amyloplastic
- Isoamylase 1, chloroplastic
Sequence:
MAAWSPSVGIGSCCLNNGITRTWKFPSARLFTGRKNKIKLGSETLMFTRKRFMGDLVTSALQSYQFSKICASKTSIELREALSSRRAEADDLKKVTSYSFRTKAGALVKVKVEKKREKYSILVYVSSLELSGDDKSRLVMVWGVYRSDSSCFLPLDFENSSQDSQTHTTETTFVKSSLSELMLGLEFDGKESPFYLSFHLKLVSGRDPDGQEMLTHRDTDFCIPVGFTAGHPLPLGLSSGPDDDSWNFSFFSRSSTNVVLCLYDDSTTDKPALELDLDPYVNRTGDVWHASVDNTWDFVRYGYRCKETAHSKEDVDVEGEPIVLDPYATVVGKSVSQKYLGSLSKSPSFDWGEDVSPNIPLEKLLVYRLNVKGFTQHRSSKLPSNVAGTFSGVAEKVSHLKTLGTNAVLLEPIFSFSEQKGPYFPFHFFSPMDIYGPSNSLESAVNSMKVMVKKLHSEGIEVLLEVVFTHTADSGALRGIDDSSYYYKGRANDLDSKSYLNCNYPVVQQLVLESLRYWVTEFHVDGFCFINASSLLRGVHGEQLSRPPLVEAIAFDPLLAETKLIADCWDPLEMMPKEVRFPHWKRWAELNTRYCRNVRNFLRGRGVLSDLATRICGSGDVFTDGRGPAFSFNYISRNSGLSLVDIVSFSGPELASELSWNCGEEGATNKSAVLQRRLKQIRNFLFIQYISLGVPVLNMGDECGISTRGSPLLESRKPFDWNLLASAFGTQITQFISFMTSVRARRSDVFQRRDFLKPENIVWYANDQTTPKWEDPASKFLALEIKSESEEEETASLAEPNEPKSNDLFIGFNASDHPESVVLPSLPDGSKWRRLVDTALPFPGFFSVEGETVVAEEPLQQLVVYEMKPYSCTLFETINTTA
Protein: Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1) (P0AC41)
Organism: Escherichia coli (strain K12)
Function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16079137}; Cytoplasmic side {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16079137}.
Interaction partners:
- Succinate dehydrogenase cytochrome b556 subunit
- Succinate dehydrogenase iron-sulfur subunit
- Succinate--CoA ligase subunit beta
- Fumarate reductase iron-sulfur subunit
- Succinate dehydrogenase hydrophobic membrane anchor subunit
- Succinate--CoA ligase subunit alpha
- 2-oxoglutarate dehydrogenase E1 component
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
- Fumarate hydratase class I, aerobic
- NADH-quinone oxidoreductase subunit C/D
Sequence:
MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRWNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFPDRDDENWLCHSLYLPESESMTRRSVNMEPKLRPAFPPKIRTY