wanglab/gogpt-training-data huggingface dataset:
Protein: Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine-binding protein 2) (Chemokine-binding protein D6) (O08707)
Organism: Mus musculus (Mouse)
Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Subcellular location: Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). {ECO:0000250}.
Interaction partners:
- C-C motif chemokine 25
- C-C motif chemokine ligand 27A
- C-C motif chemokine 27
- Mucosal addressin cell adhesion molecule 1
- C-C motif chemokine
- C-C motif chemokine 2
- C-C motif chemokine 22
- C-C motif chemokine 28
- C-C motif chemokine 3
- C-C motif chemokine 19
Sequence:
MPTVASPLPLTTVGSENSSSIYDYDYLDDMTILVCRKDEVLSFGRVFLPVVYSLIFVLGLAGNLLLLVVLLHSAPRRRTMELYLLNLAVSNLLFVVTMPFWAISVAWHWVFGSFLCKVISTLYSINFYCGIFFITCMSLDKYLEIVHAQPLHRPKAQFRNLLLIVMVWITSLAISVPEMVFVQIHQTLDGVWHCYADFGGHATIWKLYLRFQLNLLGFLLPLLAMIFFYSRIGCVLVRLRPPGQGRALRMAAALVIVFFMLWFPYNLTLFLHSLLDLHVFGNCEISHRLDYTLQVTESLAFSHCCFTPVLYAFCSHRFRRYLKAFLSVMLRWHQAPGTPSSNHSESSRVTAQEDVVSMNDLGERQSEDSLNKGEMGNT
Protein: Scrapie-responsive protein 1 (Scrapie-responsive gene 1 protein) (ScRG-1) (O75711)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Sequence:
MKLMVLVFTIGLTLLLGVQAMPANRLSCYRKILKDHNCHNLPEGVADLTQIDVNVQDHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNQ
Protein: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (Potassium channel tetramerisation domain containing 10) (Potassium channel tetramerization domain-containing 10) (Q6P7X5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cullin-3A
- Cullin 3
- UBX domain protein 7.
- E3 ubiquitin-protein ligase RBX1
- UBX domain-containing protein 1
- BTB/POZ domain-containing protein KCTD14
- FAS-associated factor 1
- BTB domain-containing protein.
Sequence:
MEEMSGESVVSSAVPAATTRTTSFKGSSPSSKYVKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGVVPLPESRRETEELLAEAKYYLVQGLVDECQAALQNKDAYEPFCKVPLVTSSKEEQRLIATANKPTVKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYESQDGRGPDNALLEATGGAAGRSHHIDEDEERERHDRVRRIHIKRPDDRTHHHQ
Protein: Probable beta-glucosidase G (EC 3.2.1.21) (Beta-D-glucoside glucohydrolase G) (Cellobiase G) (Gentiobiase G) (Q2U325)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Probable glucan endo-1,3-beta-glucosidase eglC
- beta-glucosidase
- beta-glucosidase
- beta-glucosidase
- Probable beta-glucosidase H
- beta-glucosidase
- Probable beta-glucosidase I
- beta-glucosidase
Sequence:
MASIAHLVVSGLLAATAVNGQNYGGSGRSDDAFSYVQPRNTTILGQYGHSPAVLPSPNATGAGGWEEALAKAQQFVAQLTLEEKADMVTGQPGPCVGNIVAIPRLGFKGLCLQDGPLAIRVADYASVFSAGVTAASTWDKDILYERGVAMGEEFKGKGAHVALGPVAGPLGRSGYGGRNWEGFAADPYLTGVAMERTIQGYQDAGVQACAKHFIGNEQETQRNPNYNPNGTLTDVIQEAISSNIDDRTIHELYLWPFANAARAKVASVMCSYQRLNGSYACQNSKVLNGLLKEELGFQGYVQSDWGGTHSGVSSIEGGLDMNMPGGLGQYGQTPEAGSFFGKNVTFAVNNGTVDISRVDDMIVRIMTPYYWLGQDQGYPEIDPSSADLNTFSPRSTWLREFNLTGERSRDVRGDHGELIRRHGAEATILLKNENKALPLKAPKSIAVFGNDAGDTTEGAVNKATFEFGTLAAGGGSGTGRFTYLVTPLEALKARGKQDNTLVQWWLNNTLIADSDVTSLWVPTPPDACLVFLKTWAEEGSDREYLSVDWNGNEVVDSVASKCNNTIVVTHSSGINELPFANHPNVTAIVAAHYPGQESGNSIVDILYGDVNPSGKLPYTIAKNGSDYNAPPTTAVETTGADDWQAWFDEKLEIDYRYFDAHNISVLYEFGFGLSYTTFSLSDIKTEPLAESISSVPEQLPIQPGGNPALWESVYNVSVTVTNTGDVKGATVPQLYVTFPDSAPAGTPPKQLRGFDKVSLAPGESQTVGFELMRRDLSYWDVVSQEWLIPEGEFTIRVGFSSRDLSQETKITPVTA
Protein: Pre-mRNA-splicing factor sap62 (Spliceosome-associated protein 62) (Q9P7L8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
Subcellular location: Nucleus {ECO:0000305|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U2 snRNP component prp10
- Uncharacterized protein C211.05
- Spliceosome-associated protein 49
- Pre-mRNA-splicing factor sap145
- Pre-mRNA-splicing factor prp12
- Pre-mRNA-splicing factor sap61
- Pre-mRNA-splicing factor sap114
- Pre-mRNA-splicing factor prp1
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor ini1
Sequence:
MDYQNRAGVRFGGGGVAGYQETNAARRERLRKLALETIDLSKDPYLMKNHLGTFECRLCLTTHANENSYLTHTQGKKHQTNLARRQALENKKSQENAPQVLLGISQSHVQVKKSVVKIGRPGYKVSKIREAESGKFGLRFQIKYPDIEVNAKPRYRIMSAYEQRVEAPDRKFQYLVVAAEPYESIAFKIDRAPGKFWSYWDAPTYTIQFFYNLTKIS
Protein: CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Nepmucin) (CD antigen CD300g) (Q1ERP8)
Organism: Mus musculus (Mouse)
Function: Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:16754720, ECO:0000269|PubMed:16876123}; Single-pass type I membrane protein {ECO:0000305|PubMed:16754720}. Basolateral cell membrane {ECO:0000269|PubMed:16754720, ECO:0000269|PubMed:16876123}; Single-pass type I membrane protein {ECO:0000305|PubMed:16754720}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:16876123}; Single-pass type I membrane protein {ECO:0000305|PubMed:16754720}. Note=Exclusively localized on capillary endothelium. Transcytoses across the cytoplasm in the capillary endothelium. {ECO:0000269|PubMed:16876123}.
Interaction partners:
- Glycosylation-dependent cell adhesion molecule 1
- Endomucin
Sequence:
MRPLVLLWGCLVLPGYEALKGPKEISGFEGDTVSLRCTYVEKMKEHRKYWCRQGGILVSRCGDIVYANQDQEVTRGRMSIRDSPQELSMTVIMRDLTLKDSGKYWCGIDRLGRDESFEVTLIVFPGKRDNAVPAGTCCPSSPTPSFQPLTPTRSLQPKAKAWQTQLPEPRSSRPVVWLPLTTPQDSRAVASSVSKPSVSIPMVRMMAPVLILLSLLLAAGLIAFGSHMLRWRKKAWLATETQKNEKVYLETSLPGNGWTTEDSTIDLAVTPECLRNLNPSAVPSPETQNLSQSTEEEEAARSLDDDKEDVMAPPPLQMSAEELAFSEFISV
Protein: F22D16.19 protein (Q9SRX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- UPF0725 protein At2g20625
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Protein LURP-one-related 15
- Splicing factor YJU2
- Exocyst complex component SEC3B
- Exocyst complex component SEC3A
- Exocyst complex component SEC5B
- Exocyst complex component SEC5A
Sequence:
MTLLPISIFFFFLFCIPSPLIAAANDDDIPTAYTLLQSYNFPVGILPKGVVSYDLDKSTGQFHAYFNKSCSFALQGSYQLDYKSTISGYISENKITKLTGVKVKVLFLWLNIVEVIRNGDELEFSVGITSANFEIDEFYESPQCGCGFDCKTKTKTLGRNPFVSSV
Protein: Galactose-1-phosphate uridylyltransferase (O07763)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable integral membrane protein
Sequence:
MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRLGSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGPRTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSIDDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGDPANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDRTAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK
Protein: Triacylglycerol lipase (EC 3.1.1.3) (Pancreatic lipase) (G1NFD3)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Cell projection, neuron projection {ECO:0000256|ARBA:ARBA00004487}. Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU362046}. Zymogen granule membrane {ECO:0000256|ARBA:ARBA00024321}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00024321}.
Interaction partners:
Sequence:
VRLDKSDAEFVDVIHTDIAPLIPNLGFGMAPAIGHLDFYPNGGVEMPGCNKNPLSQIVDLDGIWEGTKDFVACNHLRSYKYYSDSIVYPDGFLGYTCGSYDAFKEGCFPCPSGGCPNMGHYADKFKGKTSDSFVKLYLNTADARDFPLWRYKVSVKLSGSSKVTGYLNIALYGNDGNTRQHQIFQGSLKPDNTYTAFVDAERKVGQVTKVKFLWNNSVVNPTLPKLGAATVTVQYGETGEVFNFCGSETVRENVLQTLTAC
Protein: G protein (Q90846)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEVARADDARQLFVLAGSAEEGVMTAELAGVIKRLWRDAGVQACFSRSREYQLNDSASYYLNDLDRISQPTYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
Protein: Low affinity inorganic phosphate transporter 5 (PhPT5) (PhPht1;5) (Arbuscular mycorrhiza-induced phosphate transporter PT5) (AM-induced phosphate transporter PT5) (H(+)/Pi cotransporter PT5) (B2CPI7)
Organism: Petunia hybrida (Petunia)
Function: Low-affinity transporter for external inorganic phosphate (Pi) probably involved in the acquisition of phosphate released by arbuscular mycorrhizal (AM) fungi during AM symbiosis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8GSG4}; Multi-pass membrane protein {ECO:0000255}. Note=Present on the periarbuscular membrane in cells containing arbuscules during arbuscular mycorrhizal (AM) symbiosis with AM fungi. {ECO:0000250|UniProtKB:Q8GSG4}.
Interaction partners:
Sequence:
MASNNLNVLNALDTAHTQWYHVTAVVIAGMGFFTDAYDLFCISTISKLLGRLYYYDPHTHAPGKLPHTVNNWVTGVALVGTLTGQLVFGWLGDKLGRKKVYGLTLILMVICALSSGLSFGYSRKVVIGTLCFFRFWLGFGIGGDYPLSATIMSEYANKRTRGAFIAAVFAMQGVGIIFAGLVLMTVSKVFLMRYAGKAFSTDEVFSTEPEADYVWRIVLMLGALPALLTYYWRMKMPETGRYTAIIEGNAKQAAIDMGKVLEIEIQAEGEKLAKFKSANDYSLLSNEFFQRHGLHLIGTMSTWFLLDIAFYSQNLTQKDIFPTMGLVSDAKSISALREMFETSRAMFVIALLGTFPGYWFTVFFIEKIGRFKIQLMGFFMMSIFMAIIGVRYDYLKTKDHKWTFAALYGLTFFFANSGPNSTTFVLPAELFPTRVRSTCHALSAASGKAGAMVSAFGVQQYTQDGEVHKIKKAMLFLAFTNMVGFCCTFLVTETKGRSLEEISGEDENQNETKMKGRPVSGGHQDDGWD
Protein: Zinc finger C2H2 protein sequoia (Q95V81)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQQSRKFEGKIPKLSQTSAATGGATAAAEASTSKSSQGQQQQIVYVNMLPAANTLNGIPQQQQQQQYASTDGNVYQLQNEILCDANGHAVTAATASYQTTASSPQQQQQQQQQQQDNVVTTISSSSILHTNANTNGVDTLAATQQQQQQQQQQQQQQQHYHYITTTGEDGQTPTTIVFENYNGGMPAVSSAAPTPVPVSQANAPATTTTTALVNTDGTIIEFDGSTYEEYHVLKSEPGSSDCLSNGSSAVAADIIKYDPQHGVVGDEEDDDENGMLHVKYEEQSLEHDPENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQEQTGSGNTVLSSMVPKSGSAAAAKQKRKRKTRVIADDEQGEYLEKMSVRGLDIARYEHIIDGVAYCLVCAKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKKDKHGDVPMPPSATTTPLKADGPPAKRARTARTPRVRKTKDGSTPTKKRLAQIDSVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLAPSTPSQPQHQLQTLPSLDFSGMILPGGAQLALANPGATSSVGLQRGPATPNGQPAPPTTTLIYSNQLELQQALLQQQLQGQSIMIQDQAGNLVPLQLDGTQAIYTTAPQAQRQQTTATYQTTQQQQQQPAQQPAGQAQQQPHYELDNVTYLSSTAAATPTSAEQQQQQQQQQHVIGTVQSYQILTPDGLQNFQPKLETAELGDLCPYSQYTFTTHAGAQPTLNANALDAQTQHQQHHQQQQHHHQQQQHHQQTQLLQQQPFATHHNPHQQFMELKNELLIKGGDAYTLDTASMYHLPFSPTSMINAVNDVNTSSLLETKEISYDISEAVLLAL
Protein: Vacuolar protein sorting-associated protein 26 (Q55CA0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 35
- Phox domain-containing protein
- PDZ domain-containing protein
- PX domain-containing protein
- PX domain-containing protein
- Vacuolar protein sorting-associated protein 26C
- Vacuolar protein sorting-associated protein 45
- TBC1 domain family member 5 homolog A
- WASH complex subunit 2
Sequence:
MNFFSNNFGTPCNVEFELDNCQNRKTIEVTQDKGKTEKLFVFIGNEPVSGKVSINIKEKTKKIEHTGIRVEFVGQIELFYDRGNHYEFTSLVRELAPAGELTENKTFSYDFSNVEKQYESYNGTNVRLRYFVRLTIGRSFASNIVKEYDIWVINFVKPPESNSNIKMEVGIEDCLHIEFEYNKSKYHLKDVIIGKIYFLLVRIKIKYMEIALIKRESTGSGPNVFNESETLTKFEIMDGAPVRGESIPVRLFLSVFDLTPTYRSVHNKFSVKYFLNLALVDEDDKKYFKQQEITLWRRGVTKPGLPGSTNNNNNNNTSNTNNTNTPQQKVTESQNEVPEPENNSSDESD
Protein: Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) (Q920M7)
Organism: Mus musculus (Mouse)
Function: Plays a role in dendrite formation by melanocytes.
Subcellular location: Membrane {ECO:0000269|PubMed:11716773}; Peripheral membrane protein {ECO:0000269|PubMed:11716773}.
Interaction partners:
Sequence:
MLEPLNEGLLSRISDVLLCGWTCQHCCQRCYESSCCQSSEDEVEILGPFPAQTPPWLMASRSNDKDGDSVHTASDVPLTPRTNSPDGRRSSSDTSKSTYSLTRRISSLDSRRPSSPLIDIKPVEFGVLSAKKESIQPSVLRRTYTPDDYFRKFEPRLYSLDSNLDDVDSLTDEEIMSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKALIPSSQNEVELGELLLSLNYLPSAGRLNVDIIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSESNHWRRMLNTHRTAVEQWHSLRSRAECDRVSPASLEVT
Protein: Large ribosomal subunit protein bL33c (50S ribosomal protein L33, chloroplastic) (Q6ENF2)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein bL32c
- Small ribosomal subunit protein bS16c
- Small ribosomal subunit protein uS8c
- Large ribosomal subunit protein bL36c
- Small ribosomal subunit protein uS11c
- 50S ribosomal protein 5
- Large ribosomal subunit protein uL14c
- Small ribosomal subunit protein bS18c
- Small ribosomal subunit protein uS15c
- Small ribosomal subunit protein uS14c
Sequence:
MAKGKDVRIRVILQCVSCVRKGANEESAGISRYSTQKNRHNTPGQLELRKFCRYCRKHTIHAEIKK
Protein: Subtilisin-like protease 4 (SbtM4) (Subtilase 4) (EC 3.4.21.-) (A9QY38)
Organism: Lotus japonicus (Lotus corniculatus var. japonicus)
Function: Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:A9QY40}. Note=Accumulates in the intercellular spaces and the periarbuscular space (PAS) during arbuscular mycorrhizal (AM) symbiosis. {ECO:0000250|UniProtKB:A9QY40}.
Interaction partners:
Sequence:
MDYFLFIALTFLLTFHVHNAQGSELPTTTTESTETSSSKIYIIHVTGPEGKMLTESEDLESWYHSFLPPTLMSSEEQPRVIYSYKNVLRGFAASLTQEELSAVEKKNGFISAHPQRVLHRQTTHTPKFLGLQQDTGVWKESNFGKGVIIGVLDSGITPGHPSFSDVGIPPPPPKWKGRCDLNVTACNNKLIGARAFNLAAEAMNGKKAEAPIDEDGHGTHTASTAAGAFVNYAEVLGNAKGTAAGMAPHAHLAIYKVCFGEDCPESDILAALDAAVEDGVDVISISLGLSEPPPFFNDSTAIGAFAAMQKGIFVSCAAGNSGPFNSSIVNAAPWILTVGASTIDRRIVATAKLGNGQEFDGESVFQPSSFTPTLLPLAYAGKNGKEESAFCANGSLDDSAFRGKVVLCERGGGIARIAKGEEVKRAGGAAMILMNDETNAFSLSADVHALPATHVSYAAGIEIKAYINSTATPTATILFKGTVIGNSLAPAVASFSSRGPNLPSPGILKPDIIGPGVNILAAWPFPLSNSTDSKLTFNIESGTSMSCPHLSGIAALLKSSHPHWSPAAIKSAIMTSADTINLGNKLIVDETLQPTDLFATGSGHVNPSRANDPGLVYDIQPDDYIPYLCGLGYSETEVGIIAHRKIKCSASIPEGELNYPSFSVELGSSKTFTRTVTNVGEAHSSYDLIVAAPQGVDVKVQPYKLNFSEVNQKETYSVTFSRTGLGNKTQEYAQGFLKWVSTKHTVRSPISVKFI
Protein: Soluble guanylate cyclase 89Da (EC 4.6.1.2) (Q9VEU6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Head-specific guanylate cyclase
- Soluble guanylate cyclase 89Db
- Guanylate cyclase soluble subunit beta-1
- Soluble guanylate cyclase 88E
- Inosine triphosphate pyrophosphatase
- Bis
- Molybdenum cofactor biosynthesis protein 1
- GTP cyclohydrolase 1
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
- cGMP-specific 3',5'-cyclic phosphodiesterase
Sequence:
MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGKGDMETYWLLEGPEG
Protein: PIAS1 (Q5QGZ1)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSLSSVHPSSMPATLSPSTIPQLSYDGHPATSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNGKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGSWAPMRSKKEVQEVTTSYNGVDGCISSSLEHQVSSHQQSNKNKKVEVIDLTIDSSSDEEEEEPSAKRSCPSISPASPINNKGILNLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQPARESWSSSCK
Protein: Transcription repressor OFP13 (Ovate family protein 13) (AtOFP13) (Q9FMC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription repressor OFP2
- Transcription repressor OFP5
- Transcription repressor OFP17
- Transcription repressor OFP3
- Transcription repressor OFP4
- Transcription repressor OFP1
- Probable transcription repressor OFP9
- Transcription repressor OFP10
- Protein CLP1 homolog
Sequence:
MGKKKMKLSSLFKGGAGGLLAVPLCYNAKTLSFRVGDDMIKTVNSVFFDHHHNNNNGGDLLEAETPESWFTNSSETASHSTESDQDLDAESLEMVVRGVVRSERLFFDPGVTSSILEEIEEKSKSDLKSKETVAVGEDRSTPIEEISVAVAMESEDPYGDFRRSMEEMVTSHGELAKDWESLESMLAWYLRMNGRKSHGVIVSAFVDLLSGLSDSGAGITSASVSDSARYSTAVSSLPSSPVYSLSQGQTEIQEEERRSC
Protein: Ras-related protein Rab-3A (EC 3.6.5.2) (P63012)
Organism: Rattus norvegicus (Rat)
Function: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 and RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17311845, ECO:0000269|PubMed:18407218}. Lysosome {ECO:0000250|UniProtKB:P20336}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:17311845, ECO:0000269|PubMed:18407218}. Cell projection, axon {ECO:0000250|UniProtKB:P63011}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Presynapse {ECO:0000250|UniProtKB:P63011}. Postsynapse {ECO:0000250|UniProtKB:P63011}. Note=Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form. {ECO:0000269|PubMed:18407218}.
Interaction partners:
- Rabphilin-3A
- Regulating synaptic membrane exocytosis protein 1
- Regulating synaptic membrane exocytosis protein 2
- Vesicle-associated membrane protein 2
- Synaptotagmin-1
- Protein piccolo
- DnaJ homolog subfamily C member 5
- Synaptophysin
- Vesicular glutamate transporter 1
- Syntaxin-binding protein 1
Sequence:
MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDCAC
Protein: CADG domain-containing protein (Q1XFY3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MVVINLVEDSLYQGNTQQVFELPINGLDVEDLVSNRDRKISQLENSLRNTFRGRNVNPYIAGVRSRYIIPRGKEHIFKNSFGTMVYVGTQQKFYPGTMSIVHNLQTMPEFCSNPSSVVMNKYFAPTFPVDWCNVAVRNISSLEGEGIDELIKDEQEEKLTKANPDQNLNEKPEQPPRELYGYSEHGFSIVLFAIILGVSILFVFALVLIFFGSREGQKWRDDKTSGETLGEFISIRDNQKKLRELSLQRQLLSMGPDTNSTAPSGIHSYLQSRSRAPSTSIARFSKSASRLNDKEDTIELLPSVDHVPVGKQTVAEAAKQCGSSLHLYRNPLSNESDEQDTESSDEDN
Protein: Phosphate transport regulator (Q72F08)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Flagellin
- Translational regulator CsrA
- Flagellin
- TPR domain protein
- FlgN family protein
- Flagellar assembly factor FliW
- Flagellin
Sequence:
MIVIDGRQTDMKLDSFANLEEILVKVLTEDYLENRIVTDVLVNEETFSEIYPHQAEDVQTDEIRSLEIRTVPVGEMAVNISRELYKVIQVMTSGAKQVATLFRQADDTEALELLQDLIDVTRDFMGMISTLRAEFSLRGGVDFQTNVDQISDLLTEMTEVLENEDWILLADLLEYEFLPVCENWKQVIQSLREDIRKAVKG
Protein: Putative lipase C4A8.10 (EC 3.1.-.-) (O14162)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized pyrophosphatase/phosphodiesterase C725.05c
- Putative arrestin-related trafficking adapter C2D10.04
Sequence:
MNVYVQRDDVGLGQIHRFRIFVQSGGNLHSATSSTTVPPTVNLNSVTKKESGSIEDRAGSGGMTISSGENISKQISENNSSTNPKHANSESSPLLSSDFSSSSKDYHKVGAFTDNTNAINIPEQTRGVSHTSSSPSVGTSFSSINLREVKNPLAGSDSTAPFINSTNSVLWIRVRNREARFRQAAYLQGPFTLCVSVWNDQFFDEKNSLLNFDPQVQPSTSFWVCVPYSCFSNQQPIYIEIASQAIFKDRSINFELAISQSQHSIRAMSAADIDTLHAFPALHVEHQTPENLWRLPYSSFHSKNSHLVVLTHGMHSNVGADMEYLKEKLIESSKSVKELVVVRGFTGNYCQTEKGVRWLGKRLGEWLLDITGWGSASFPRYSHISVVAHSLGGLVQTYAVGYVHAKTHGAFFQAIHPVFFVTLATPWLGVAGEHPSYIGKALSYGIIGKTGQDLSLTPLNHSIESRPFLVLMSDPSTPFFQAVSFFEKRILFANTTNDYIVPFGTSAMEVSSLGKVEEAEGSDKVMPTHMENGISPTLKENEQTVQSVGDNAKKIHASSEESGSSFSKALKSFVGLFSYSASKTTDTEIPLVKNEDENARKPTEPNCLGSDELDVSNSSNQFFCSAPKLDPTSTFSGVAQRVVNTFTNLFIPAVPTDSYFFKYHLHKVVVSDNVHDPAASFSTFDGITELNNMNNGFLSNEITIAKNWHRLAWRKVAVRLDGDAHNTMIVRRRFPNAYGWTVIKHLTEILFEQNTSTAYMNPISFDETTTAAWLSEIYEDNSISV