wanglab/gogpt-training-data huggingface dataset:
Protein: Prospore membrane adapter protein SPO71 (Sporulation-specific protein 71) (Q03868)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Recruits the lipid transfer protein VPS13 to the prospore membrane during sporulation, thereby aiding prospore membrane formation.
Subcellular location: Prospore membrane {ECO:0000269|PubMed:24036347, ECO:0000305|PubMed:22611022}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Intermembrane lipid transfer protein VPS13
- Endosomal/vacuolar adapter protein YPT35
- Sporulation-specific protein 73
- Mitochondrial adapter protein MCP1
- Putative meiotic phospholipase SPO1
- ATP-dependent RNA helicase DHH1
- Sporulation-specific protein
- Autophagy-related protein 2
- Large ribosomal subunit protein bL27m
- Sporulation-specific protein 20
Sequence:
MDSIVNVVEDDVKYAQRVTSFSSPQNANVKVFTIPRHSFTAFRLSYVSPTELSACSQVTLLGGIPKQWYADQNNQVWKLLTKISLRKVRKQSDMLRRYGYGTIYKKRVGKIPTALYLRKHFTWSYEDNTSIHNGHRLKEAEMEMKRTRSSPVQKSEYKLSLPRRCRSSSDQNFMRQELLKEKKSELSRNNSLPLIDTAQAVDIHPVLHEEDQENTNKRNKSLLSNLKRKDLGESKSISRKDYSHFDRIPSPSSARSVGETDFNYNREPSEDTLRYPDSIIEVTNRTSPAPNSILSRSGQFVNSNDLSDGFSTSNTINNVGLNANEKIFFNALQSMEKENLMLWKTSQKYGTYLDERRKSADAFQKRERGSCVDIGKLHSSHLPFINILPPWPTELTEEERIIHDRLASKHSHHIRKHVHNARNKTSCKIKDSVGTFLGMTNSLTNKATVKKRTGQILKKEKMLVMVKEAIQNKVPLPNFSENECFDTRVSERWKEYIVIARSTGRFDPPILLQFYRHRHIPEIEDISSIATKYHRNPLDFFLSRNCIVKFYSSLDKTISIQKPDKRLGGFIDESIEKKDELKHYSPIKIFILRCSSIRSSGRWYKFLLESLDRQLFTPAINLKIPLTEISIKINLNEIIFQKLIDLGKQEKDRLKICFLQRGYKIFQHPILRYFTVAILEKLKLAHYDYLIRKWDTENPVLGCALKRYDRLEWIPCDEDSLVTGIFAFCQSHLIQYRPIANRLRETKSLEGKCLKEPTPIEGFLIRLTDKYGSARTNFGKYSISTAYFFTCENLLFSMKAYRANPPLPIDSMIDDTSTEIEKEEIWKQWKKIPEVYEQQPYPLDTNDHIEWMNCQTTQSEYDSRDFYAFHCFHRRIDQILKTDNVIDLTEVKDIYQGTRTDYEADKIKYGVYKEASEIFWHRNYEIDDVSRSVINIETSNGLLLKLLATSATVAEEWVIKLKQMISYWKNKQREDTERLLKIRRSNAGLLMLNGEEETKIGENTLRWIVEHGRADEQTFNANGISLSRPLIQKGPLYQKPHKHSVFSKYYVVLISGFIVLFHCFHRSTTGFAKEVLEYAHYVTIPIDDCYLYSGTTTELDLLQRDRTFDEINYGSHALPRVYGDGWRSVEDESSRCFTLWFGTRRALSSNRLQKKGNEKQYTQDYGRQDNNIDPPSAPEADLNNSNVPSNTDKIHFTKKLGVSGKSMVFMARSRQERDLWVMSIYYELERLRRTASTSNSRNQTM
Protein: Protein LURE 1.2 (AtLURE1.2) (Cysteine-Rich Peptide 810_1.2) (CRP810_1.2) (Defensin-like protein 213) (Q4VP08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pollen tube attractants guiding pollen tubes to the ovular micropyle. Attracts specifically pollen tubes from A.thaliana, but not those from A.lyrata. Triggers endocytosis of MDIS1 in the pollen tube tip.
Subcellular location: Secreted {ECO:0000269|PubMed:23271953}. Note=found at the micropylar end of the female gametophyte, possibly at the filiform apparatus of the synergid cell. Difuses to the surface of the funiculus of the ovule through the micropyle. {ECO:0000269|PubMed:23271953}.
Interaction partners:
- Pollen receptor-like kinase 6
- Protein MALE DISCOVERER 1
- MDIS1-interacting receptor like kinase 1
- Pollen receptor-like kinase 1
- MDIS1-interacting receptor like kinase 2
- Inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Pollen receptor-like kinase 3
- At4g07515)
- Defensin-like protein 44
- Egg cell-secreted protein 1.3
Sequence:
MKLPIIFLTLLIFVSSCTSTLINGSSDEERTYSFSPTTSPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRCSISDIK
Protein: Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) (O95379)
Organism: Homo sapiens (Human)
Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14724590}.
Interaction partners:
Sequence:
MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI
Protein: E3 ubiquitin-protein ligase cblA (EC 2.3.2.27) (Cbl-like protein A) (RING finger protein cblA) (RING-type E3 ubiquitin transferase cblA) (Q557E7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Up-regulates STATc tyrosine phosphorylation via an inhibitory effect on ptpC accumulation. Recognizes activated receptor tyrosine kinases, RTKs and terminates signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18840649}. Nucleus {ECO:0000269|PubMed:18840649}. Note=A very small proportion appears to be nuclear but this may reflect cytoplasmic contamination of the nuclei.
Interaction partners:
Sequence:
MNRATITSNKSNAPSFLSIPLLAHNNNINNNNNNINNNNNNNNINSNNNGTTTTTTTTTITTISYKNNISELITIIDKIIKDLNNFKSKTVLNDQEFSELNNTIQFTKTSLVNYIHYENENKINFNLSDSKIICSEIKIIEYGIESFIFSICKLYQDLIQFQQLLLKLSSPPTTITFNTTINSTNSFTSNLIINNLLKVDSILKQSIDQLLALFPPSSSSLNNENNNNNNNNYNPYELLSNEAKVLWNQFGGNKITFVPWSIFFKGFQKFFNKEILAYESSLRYTLDFTRDGYVTPFKLSVFIKWFGALPVSLGIFQDVINSKIFSGFISGIEATQLLSRQQVGYYLLRCSKTIVGAFAITFVDSTNHIRHCLLYPVTSSINGGLTLQKPPDIFKSILSFILSFSSKLKYPIGPLDNDLLPPLSIINNNPILILPDENNNNQNNNQNNNNNNINTFSTSPSSFFTIDSSNSSDTNKSPTKSRKSSFKNDKDKKEKEKEKGKDKEKEKERVSDENFDNLPTFLNSEDENDNNNNNNNNNNNNNNNNNNNNNNNNNNSSNNNNCNIKETHQTTSNGSSGNNNNNNNNNNNNNNNNNNNNSSSTTKRNNNNNGSDESKDLCTVCMDNEINTVFLECGHLSCCSLCSVKLKKCPICRSRITRVINIFKS
Protein: Diacylglycerol O-acyltransferase 1A (GmDGAT1A) (EC 2.3.1.20) (Q5GKZ7)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Major contributor to triacylglycerol (TAG) synthesis and oil accumulation in developing seeds. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Has a marked preference for oleoyl-CoA (18:1) and sn-1,2-dioleoylglycerol over vernoloyl-CoA and sn-1,2-divernoloylglycerol. Can use oleoyl-CoA, linoleoyl-CoA and linolenoyl-CoA as substrates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27345221}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Diacylglycerol O-acyltransferase 2D
- Acyltransferase
- Acyltransferase
- Acyltransferase
- Diacylglycerol O-acyltransferase 1B
- Diacylglycerol O-acyltransferase 3-2
- diacylglycerol O-acyltransferase
- Diacylglycerol O-acyltransferase 3-1
- AP2/EREB-box binding protein
- Phospholipid:diacylglycerol acyltransferase
Sequence:
MAISDEPETVATALNHSSLRRRPTAAGLFNSPETTTDSSGDDLAKDSGSDDSISSDAANSQPQQKQDTDFSVLKFAYRPSVPAHRKVKESPLSSDTIFRQSHAGLFNLCIVVLVAVNSRLIIENLMKYGWLIKSGFWFSSKSLRDWPLFMCCLSLVVFPFAAFIVEKLAQQKCIPEPVVVVLHIIITSASLFYPVLVILRCDSAFLSGVTLMLFACVVWLKLVSYAHTNYDMRALTKSVEKGEALPDTLNMDYPYNVSFKSLAYFLVAPTLCYQPSYPRTPYIRKGWLFRQLVKLIIFTGVMGFIIEQYINPIVQNSQHPLKGNLLYAIERVLKLSVPNLYVWLCMFYCFFHLWLNILAELLRFGDREFYQDWWNAKTVEDYWRMWNMPVHKWMIRHLYFPCLRHGIPKAVALLIAFLVSALFHELCIAVPCHIFKLWAFGGIMFQVPLVFITNYLQNKFRNSMVGNMIFWFIFSILGQPMCVLLYYHDLMNRKGKLD
Protein: Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (B9DGD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the production of acetyl-CoA, an activated form of acetate that can be used for lipid synthesis or for energy generation. May play a limited role in the biosynthesis of lipids.
Subcellular location: Plastid, chloroplast. Glyoxysome.
Interaction partners:
- Citrate synthase 4, mitochondrial
- Citrate synthase 5, mitochondrial
- Citrate synthase 3, peroxisomal
- Citrate synthase 1, peroxisomal
- Citrate synthase 2, peroxisomal
- Malate synthase
- Acetyl-CoA acetyltransferase 2
- Acetyl-CoA acetyltransferase 1
- Aldehyde dehydrogenase family 3 member H1
- Dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial
Sequence:
MKIGSPSSPILSVVSSSGSLDPKISGSLGSRILPATQRSSPSENLLLHRKMSSNSLRHVESMSQLPSGAGKISQLNAVVLGESLASEENDLVFPSKEFSGQALVSSPQQYMEMHKRSMDDPAAFWSDIASEFYWKQKWGDQVFSENLDVRKGPISIEWFKGGITNICYNCLDKNVEAGLGDKTAIHWEGNELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQSSKDGVSVGICLTYDNSLATTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKFVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGDSRCPISDTWWQTETGGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSWPGAFRTLFGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEELGDTSTLADPSVVDQLIALADV
Protein: Meiosis-specific APC/C activator protein AMA1 (Activator of meiotic APC/C protein 1) (Sporulation-specific protein 70) (P50082)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Required for the ubiquitination and subsequent degradation of the B-type cyclin CLB1 by the APC/C complex during meiosis. Required for meiosis I, late meiotic gene expression and spore wall assembly.
Interaction partners:
- Anaphase-promoting complex subunit MND2
- Anaphase-promoting complex subunit CDC27
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-1
- Anaphase-promoting complex subunit CDC16
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit DOC1
- Anaphase-promoting complex subunit CDC23
- Sporulation-specific protein 1
Sequence:
MATPHLYHRYNSKSSNKNINSSGNSTEVDRFIPKSVSRNAYKSIPMLNGFDISYSELCEKSPSPERLSSPEFFNELRNTGHYESISTTNEFSMSSISSSSESQVTRSGSARASRNDYSKLTKEQKDHRKNIAHSLGFQLPDRVFTFETTSAEILEKNKAIKNCFGPGSCAEIRSTFDFSTLSPDVARYYIANSNARSASPQRQIQRPAKRVKSHIPYRVLDAPCLRNDFYSNLISWSRTTNNVLVGLGCSVYIWSEKEGAVSILDHQYLSEKRDLVTCVSFCPYNTYFIVGTKFGRILLYDQKEFFHSSNTNEKEPVFVFQTESFKGICCLEWFKPGEICKFYVGEENGNVSLFEIKSLHFPIKNWSKRQKLEDENLIGLKLHSTYQAQAQQVCGISLNEHANLLAVGGNDNSCSLWDISDLDKPIKKFVLPHKAAVKAIAFCPWSKSLLATGGGSKDRCIKFWHTSTGTLLDEICTSGQVTSLIWSLRHKQIVATFGFGDTKNPVLITLYSYPKLSKLLEVRSPNPLRVLSAVISPSSMAICVATNDETIRFYELWNDKEEIINEIQESGIYGSNIIEYMEGIETTHNKRIR
Protein: SAM-motif ubiquitously expressed punctatedly localized protein, isoform D (SAM-motif ubiquitously expressed punctatedly localized protein, isoform E) (M9PB98)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKEIDTETTVVWPAWCYSGNAPTDILQQKPAKATTAIVGGRSAAQPATHDDQEAATTASTATKRKHLERLASDLRQLGKKGRRSRSVSPCSRYPAVAETARMLSERSLLLSGYGAIESSAKKLSEAATGGAGGGGGGAAGQAATPTTSQLSAPASSASSSSMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKMDNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQSSQPSLGHSVKRERLSPGSNSSSHNGELTVSSFARSRSATPSSSSYRGAGGGAGGGVSPSHQQQQQQQQQSLQQQQRLSPPSGPSMATATTTSSLSSSSSASASASASASAATHMPLHNLSTNLLNSIQQAAASQQQLRSSNSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTAKKLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSGGGGSSMSQLAPPPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQQRSGSNASSPSASAAGTPRSSSTLNAALHQAAQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDSTTVAPIGDGGGGSSIASAAPLDLSSQPPAAKRFKAERRASSTATTATTATTGSSTSTPSPPPLEQHDDINSGNANATLGTRSGTGTGESSAAGSGAGVAKARRRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQLIKQEVSMEKGSFLYQLIEFYGPAGRGK
Protein: M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) (P30306)
Organism: Mus musculus (Mouse)
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P30305}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P30305}.
Interaction partners:
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase Chk1
- 14-3-3 protein beta/alpha
- 14-3-3 protein epsilon
- Serine/threonine-protein kinase PLK1
- Serine/threonine-protein kinase Chk2
- Cyclin-A2
- 14-3-3 protein zeta/delta
- Cyclin-dependent kinase 2
- 14-3-3 protein eta
Sequence:
MEVPLQKSAPGSALSPARVLGGIQRPRHLSVFEFESDGFLGSPEPTASSSPVTTLTQTMHNLAGLGSEPPKAQVGSLSFQNRLADLSLSRRTSECSLSSESSESSDAGLCMDSPSPVDPQMAERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLEHSPVLQSITNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELPHSSSAQALAEWVSRRQAFTQRPSSAPDLMCLTTEWKMEVEELSPVAQSSSLTPVERASEEDDGFVDILESDLKDDEKVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPQDRDVPVQSKRRKSVTPLEEQQLEEPKARVFRSKSLCHEIENILDSDHRGLIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMPCSLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFRDELRNFRLKTRSWAGERSRRELCSRLQDQ
Protein: PLASMODESMATA CALLOSE-BINDING PROTEIN 2 (AtPDCB2) (Glucan endo-1,3-beta-glucosidase-like protein 3) (Q9SD84)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Able to bind (1->3)-beta-D-glucans (laminarin).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19223515}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19223515}. Cell junction, plasmodesma {ECO:0000269|PubMed:19223515}.
Interaction partners:
- Choline transporter protein 1
- Glucan endo-1,3-beta-glucosidase 10
- Defective in cullin neddylation protein AAR3
Sequence:
MAPLVLYLLTLLMAGHTSASWCVCKTGLSDSVLQKTLDYACGNGADCNPTHPKGSCFNPDNVRAHCNYAVNSFFQKKGQASESCNFTGTATLTTTDPSYTGCAFPSSASGSSGSGSTTVTPGKNSPKGSNSITTFPGGNSPYSGTPSTGLLGGNITDATGTGLNPDYSTESSGFALYYSNNLLLTGFCSLVMML
Protein: DRBM domain-containing protein (Q55E25)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- RNA helicase
- RNA helicase
Sequence:
MSNKSHTSEKVQLNEFLQKKKQPIPIYHTESKGSEHNKDFKSIVVVNGKQIESDWKKSKKESEKDCAKNILEFIETLDGYPIYFTPFSKDPPQNNKKIYDEKLQAVYNSVSSGIEGLNNNSFFTKIENNNNNSSSNNNNNLDHNHSNDSSHTSTDNNDNNSNNHNNNNNNQINIDLTMENVNISQSKTITNEGTLNNDNDNNNNSIQQQQHQPQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQCFDKDKTNLKKKKKIPFSYNTDLIEHIDLFKRQDFPQTYPSRTTYTDTGHTQQLQKQVFLLTEKIGLMELFYKKQIRVILKSHHNLETELSALKSFVEDCSVTPIEGLELYSIPVPLNPNAKPSAGTTPVLSKSETQNEIIQPTKPPTKPPASCLIKKKIPNVNMKATNKTTTTTSTSTSNSSTTIKTTDSFKNTTNNQHPNTLKPMVSKINQQTSDFIFPLPKPIIRRNPIGNGNLEKKIEKKNSKPNTIVLGVDTQSQSKTKITPSPTTPPPETTPTTPTTTATPTTPTTPTTPTTTATPPPTTTATPPPTTTATPPPTATTPPPTTATTTPPPPPIIATTKTTATATATTIPIDLNEIQIPIRSPQDLTVNQSMISTAMMIASAAQRNPKLTMKLKRKLEESPTLMSKLQKIQFEKEEEILCSQDLHSPIMSPQSPTHQPKTLEPLSPTKKSTQKSPPPTSPSPIVTRARASSNLLPIQNLISKK
Protein: Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) (Q9Y6W3)
Organism: Homo sapiens (Human)
Function: Calcium-regulated non-lysosomal thiol-protease.
Subcellular location: Nucleus.
Interaction partners:
- Oxidoreductase NAD-binding domain-containing protein 1
- Xin actin-binding repeat-containing protein 1
- Calpain small subunit 1
- Calpain small subunit 2
- IST1 homolog
- Calpastatin
Sequence:
MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLGANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMPFCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNPGLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ
Protein: Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) (P60824)
Organism: Mus musculus (Mouse)
Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:17967451}. Cytoplasm {ECO:0000269|PubMed:17967451}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation (By similarity). Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins. {ECO:0000250}.
Interaction partners:
- Toll-like receptor 4
- Triggering receptor expressed on myeloid cells 1
- Heterogeneous nuclear ribonucleoprotein K
Sequence:
MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSYRDSYDSYATHNE
Protein: Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (Q8MRV7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMRSVINQLLGLRLSGNSSVLVTQVRDKGHLSRPRLRNPQWFLRKEITKYNDLMTAENKQFVNEVGTNNFGVPVVIKDCLVKTAGPTANEAVWTPNLRRCGVIARKIGQYPLWLKNGERIRTTLLQIVDNHVIKYIPPEEYLPAQVPTVANLHKRGCILVGSETTNPALLTKEYAGIFRNSGVLPKKNLARFIVSPEAQLAPGTPLNVNHFRVGDFVDVRGKTVDHGFQGVVKRHGFKGMPASHGVTKTHRRAGNIGGGGEKGRVWPGTKMPGHMGNRWRIIKGLRVWRINTKYNVMWVQGSSVAGPTGGLVYIYDTILPTRKNKEAPPFPTFYGEPQQDGDDVWYEQVHNFKSESITYENE
Protein: CASP-like protein 5B3 (AtCASPL5B3) (Q8L7R5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:24920445}; Multi-pass membrane protein {ECO:0000269|PubMed:24920445}.
Interaction partners:
Sequence:
MIDIPGTPGTLTGLVLRISQCVFAAGSISYMVTSGGFFSFTAFCYLIAAMGLQVIWSFGLAILDTFALVRKKTLLSPVLVSLFVVGDWVTSTLSLAGASSSAGITVLYFGDLGSCSFEAECWKYQLSVALAFLCWITIAVSSLTTLWLLASA
Protein: Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) (Q07817)
Organism: Homo sapiens (Human)
Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Subcellular location: [Isoform Bcl-X(L)]: Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
Interaction partners:
- BH3-interacting domain death agonist
- Activator of apoptosis harakiri
- Phorbol-12-myristate-13-acetate-induced protein 1
- Cellular tumor antigen p53
- Beclin-1
- Apoptosis regulator Bcl-2
- Bcl-2-interacting killer
- Apoptosis regulator BAX
- Bcl-2-binding component 3, isoforms 3/4
- Bcl2-associated agonist of cell death
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Protein: Protein containing ALS2cr12 (ALS2CR12) signature (O45257)
Organism: Caenorhabditis elegans
Interaction partners:
- Trichohyalin-like
- DUF305 domain-containing protein
- Transthyretin-like family protein
- non-specific serine/threonine protein kinase
- Protein containing ALS2cr12
- Protein containing ALS2cr12
- Protein containing ALS2cr12
- Retrotrans_gag domain-containing protein
- Uncharacterized protein
- Protein containing ALS2cr12
Sequence:
MNASRQKEILEAIQREEQALRNQKNAYEEELMTREKIDQEMLKQAYENKNHIEETIFAEIDALKEKNVRFQEKCHNERKQFGLKIWKTVEENNADVLNEMQRTNEIKLGNQQNKVDRELRMHALEQWTPETKVYVGNELKKDRKEAVFIVAVKRIVSAGQDLTDEVDSLADHTFELTTGCKRSALESDIGLCEHIVSMIISKIAELQDRCLEISIFCTTDHTMVKPVQKNAEEIGKSAREILMHLERFQVSLSDDPNTNSIKLFESVQTKNDRLKRMIKLIPDVTETNYAVTYLKKRIENGMDL
Protein: Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (Q96MG8)
Organism: Homo sapiens (Human)
Function: Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity. May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P22061}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Pleckstrin homology domain-containing family A member 7
Sequence:
MGGAVSAGEDNDDLIDNLKEAQYIRTERVEQAFRAIDRGDYYLEGYRDNAYKDLAWKHGNIHLSAPCIYSEVMEALKLQPGLSFLNLGSGTGYLSTMVGLILGPFGINHGIELHSDVVEYAKEKLESFIKNSDSFDKFEFCEPAFVVGNCLQIASDSHQYDRIYCGAGVQKDHENYMKILLKVGGILVMPIEDQLTQIMRTGQNTWESKNILAVSFAPLVQPSKNDNGKPDSVGLPPCAVRNLQDLARIYIRRTLRNFINDEMQAKGIPQRAPPKRKRKRVKQRINTYVFVGNQLIPQPLDSEEDEKMEEDNKEEEEKDHNEAMKPEEPPQNLLREKIMKLPLPESLKAYLTYFRDK
Protein: Solute carrier family 25 member 16 (Graves disease autoantigen) (GDA) (Graves disease carrier protein) (GDC) (Graves' didease protein) (hGP) (Mitochondrial solute carrier protein homolog) (P16260)
Organism: Homo sapiens (Human)
Function: Required for the accumulation of coenzyme A in the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:11158296}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Large ribosomal subunit protein eL18
- Ubiquitin-like protein FUBI
- Citrate synthase, mitochondrial
- E3 ubiquitin-protein ligase TRIM13
- Mitochondrial carrier homolog 2
- Mitochondrial carrier homolog 1
Sequence:
MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN
Protein: Cell division cycle 73 (A0A1B0GUB2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
Protein: Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1 aldehyde reductase 2) (AFB1-AR 2) (O95154)
Organism: Homo sapiens (Human)
Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Subcellular location: Cytoplasm.
Interaction partners:
- Aflatoxin B1 aldehyde reductase member 2
- Aldo-keto reductase family 1 member B1
- Musculin
- Aldo-keto reductase family 1 member A1
Sequence:
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR