wanglab/gogpt-training-data huggingface dataset:
Protein: Ethylene-responsive transcription factor ERF003 (Q94AW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MARPQQRFRGVRQRHWGSWVSEIRHPLLKTRIWLGTFETAEDAARAYDEAARLMCGPRARTNFPYNPNAIPTSSSKLLSATLTAKLHKCYMASLQMTKQTQTQTQTQTARSQSADSDGVTANESHLNRGVTETTEIKWEDGNANMQQNFRPLEEDHIEQMIEELLHYGSIELCSVLPTQTL
Protein: Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) (P51647)
Organism: Rattus norvegicus (Rat)
Function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00352}. Cell projection, axon {ECO:0000250|UniProtKB:P24549}.
Interaction partners:
- Alcohol dehydrogenase class-3
- Retinol dehydrogenase 10
- Cytochrome P450 26A1
- Cytochrome P450 26B1
- All-trans-retinol dehydrogenase [NAD
- Cytochrome P450, family 26, subfamily C, polypeptide 1
- Aldehyde oxidase 1
- Aldehyde oxidase 3
- Aldehyde oxidase 2
- Aldehyde oxidase 4
Sequence:
MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS
Protein: SR-CI (Q5ELS7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSIDLDNGSINYRQRNMVRFRCNRGYTLQGTVMQTCDRYGRLRGEKPFCASRGCAKPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKEMLTTTEDDISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTTMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIDGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLRKQRKRNSMDDQPLCDSDNDDVDYFEEMGVDIRHRTDL
Protein: AT5g03660/F17C15_80 (Transcriptional activator (DUF662)) (Q940P0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- COX assembly mitochondrial protein
- Ribosomal protein L31
- Ribosomal protein L18e/L15 superfamily protein
- Defensin-like protein 196
- At3g05070
- Uveal autoantigen with coiled-coil/ankyrin
- Small ribosomal subunit protein uS17y
- Prefoldin subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 7
- DEK domain-containing chromatin associated protein.
Sequence:
MQPTETSQPAPSDQGRRLKDQLSESMSFSSQMKKEDDELSMKALSAFKAKEEEIEKKKMEIRERVQAQLGRVEDESKRLAMIREELEGFADPMRKEVTMVRKKIDSLDKELKPLGNTVQKKETEYKDALEAFNEKNKEKVELITKLQELEGESEKFRFKKLEELSKNIDLTKP
Protein: 4-hydroxy-2,2'-bipyrrole-5-methanol synthase PigH (HBM synthase) (EC 2.3.2.-) (Aminotransferase PigH) (Q5W264)
Organism: Serratia sp. (strain ATCC 39006) (Prodigiosinella confusarubida)
Function: Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L-malonyl group (malonyl-S-PigH), which is decarboxylated by PigJ to yield a C2 carbanion acetyl-S-PigH. Then the pyrrolyl group of pyrrolyl-S-cysteinyl PigJ intermediate is captured by the C2 carbanion acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH. In the last step, PigH catalyzes the decarboxylative condensation between the pyrrolyl-beta-ketoacyl (pyrrolyl-beta-ketoacyl-S-PigH) and L-serine to yield 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- L-threonine 3-dehydrogenase
- Non-ribosomal peptide synthetase
- Probable NAD
- Beta-ketoacyl synthase PigJ
- Non-ribosomal peptide synthetase
- Probable acyl carrier protein PigG
- ATP-dependent dethiobiotin synthetase BioD
- Aminotransferase PigE
- L-proline--[L-prolyl-carrier protein] ligase
- Glycine dehydrogenase
Sequence:
MNDVTTETYETLKQSVLHTFAQLTGYNVSELSLTSHLENDLGVDSIALAEIAVSLSRQFQLNTPLLIQDINTIKDALDGILQREFQLSEKVEPAAIALSGDADLWLGNLVRQIFASHSGYDVNALALDAEIESDLGIDSVSVASAQGELFNTLQLNSETIIANCNTLSALKQCLAARLVQEKGQDWFEQRGRGQSDSAIDHDADTTAEVTPPTATPVAINAEIGDPRTMRDFVGIEHPDIFHKAREFHLFYQDKKKRQLYFYGMPLETPCKNRAVMFDEATGQHREFLMFGSNSYLGLSNHPEIIHAIQDAASLYGATNTGCRIIAGSNVLHLELERKLAKLKGRDDCIVYPSGYSANLGCISALTSRHDLVFTDAINHMSIQDGCKLAGAQRKIYNHSLTSLEKSLAKYADHPGGKLIVTDGVFSMHGDIVDLPRLMKLAERYGARVLVDDAHSTGVLGKTGAGTSEHFNMKGQVDLELGTMSKALSGLGGYVCGDGDVVEYLRFYSNSYVFAATIPAPVAAGVIASIDVMLREPERLAKLWDNIYYFRTRLLNAGFDLENSDSAIIPIVVGDDAKTLFFGRAVRARGMFCQTVVFPGVSVGDARLRISITSEHTREDLDEAYAILVASALEVGVPVNASAHQEENASVAEA
Protein: Fumble, isoform B (EC 2.7.1.33) (LD24618p) (Q9VPG5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTEDEQINLRNQLARAMPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSSTADEPPEKAPTSKHSTR
Protein: BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2) (Q14681)
Organism: Homo sapiens (Human)
Interaction partners:
- Cullin-3
- BTB/POZ domain-containing protein KCTD17
- Speckle-type POZ protein
- Speckle-type POZ protein-like
- SUMO-activating enzyme subunit 2
- RNA-binding protein with serine-rich domain 1
- Proliferating cell nuclear antigen
- Large ribosomal subunit protein mL50
- BTB/POZ domain-containing protein KCTD1
- Importin-13
Sequence:
MAELQLDPAMAGLGGGGGSGVGDGGGPVRGPPSPRPAGPTPRGHGRPAAAVAQPLEPGPGPPERAGGGGAARWVRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLEEAEFYNIASLVRLVKERIRDNENRTSQGPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLISIGSSYNYGNEDQAEFLCVVSRELNNSTNGIVIEPSEKAKILQERGSRM
Protein: Transcription factor AP-2, isoform E (M9PD85)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTLAYVDMPAVIQVQERLSGHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSDFQPPYFPPPFHHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAISAGAAHGTRLGHEHESLALHQALQNAVDDVQAPALDDNVAFMSDLPLIKSMKSGKEAGNIGSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNEKK
Protein: Fumarate hydratase 1, mitochondrial (Fumarase 1) (LmFH-1) (EC 4.2.1.2) (Q4QAU9)
Organism: Leishmania major
Function: Catalyzes the reversible hydration of fumarate to (S)-malate. Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (Probable).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22569531}.
Interaction partners:
- Putative malic enzyme
- malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase
- malate dehydrogenase
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Fumarate hydratase 2
- Citrate synthase
Sequence:
MLRRLAPLLAEFNFVPLVSKVSHKETKYRLLTKDYVSVVQPGAGLPEMLRVDPAALTLLSSTAFDDVEHLLRSSHLMSLRKIFDDPEASDNDKFVALQLLKNANISSARLLPGCQDTGTAIIAGYRGDQVFVPGNDEEALSRGVYDIFQKRNFRYSQNVPLSMYDEKNTGTNLPAQIDLYASKGMEYSFMFVAKGGGSANKSFLLQETKSVLNPKSLRNFLKEKLAMFGTSACPPYHVAVVIGGTSAEMTMKVLKYASCHYYDDLITKPDMKTGYTFRDLELEEEVLKVCQNIGMGAQFGGKYYAHDVRVIRMPRHGASCPIGIGVSCSADRQALGKINKDGVWLEELEMEPSQYLPDLKEDELLKTPAVMVNLNRPMPEVLQELSKHPVRTRLSLTGTIIVARDSAHARMREMLEAGKPLPQYMKEHPVYYAGPAKQPDGLPSGSFGPTTAGRMDPFVDLFQSHGGSMVMLAKGNRSKQVTKACHKYGGFYLGSIGGPAAVLAQNAIKKVECLDMKDLGMEAVWRIEVENFPAFIVVDDKGNDFFEQL
Protein: Acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (Ergosterol biosynthesis protein 10) (P41338)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). ERG10 catalyzes the formation of acetoacetyl-CoA from acetyl-CoA. The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:5571830}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Acetyl-coenzyme A synthetase 2
- Mevalonate kinase
- Acetyl-coenzyme A synthetase 1
- Diphosphomevalonate decarboxylase
- Phosphomevalonate kinase
- Citrate synthase, peroxisomal
- Acyl-coenzyme A oxidase
- Farnesyl pyrophosphate synthase
- Acetyl-CoA carboxylase
Sequence:
MSQNVYIVSTARTPIGSFQGSLSSKTAVELGAVALKGALAKVPELDASKDFDEIIFGNVLSANLGQAPARQVALAAGLSNHIVASTVNKVCASAMKAIILGAQSIKCGNADVVVAGGCESMTNAPYYMPAARAGAKFGQTVLVDGVERDGLNDAYDGLAMGVHAEKCARDWDITREQQDNFAIESYQKSQKSQKEGKFDNEIVPVTIKGFRGKPDTQVTKDEEPARLHVEKLRSARTVFQKENGTVTAANASPINDGAAAVILVSEKVLKEKNLKPLAIIKGWGEAAHQPADFTWAPSLAVPKALKHAGIEDINSVDYFEFNEAFSVVGLVNTKILKLDPSKVNVYGGAVALGHPLGCSGARVVVTLLSILQQEGGKIGVAAICNGGGGASSIVIEKI
Protein: Hepatocyte nuclear factor 4 gamma (A0A6E1WB48)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MMRVSEPILDMDMANYSEVLDPTYTTLEFETMQILYNSSDSSAPETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL
Protein: Uncharacterized protein DDB_G0287317 (Q54KJ1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MMSYEQQQYLTQQQQMNNFTNLTNLTNMNSVNHNFGLMQQQQLVPQQPQLAPPPPPQHQQIPISTQSTPNSTSSTTTTTTTTTSTTTAPTSNSKKSKTTPSNGNKPTSGMVTPIISTPLQLSSVNTPLQQYQPNSQLQPPSPIIKKSSLSTTPNNINNNNNNNNNTNTISPKTKGGNNSAPTPTYSSATINSPYLEVIEQESISVENVIINNRNSNVHIVVKNTSFVLKIRSLDLNKINFSSSCVKAGLYYVNEPLKEVSFIQNPPITYVGSSCKNGEQFAIDIKISILSSQHQGNLFYIMVHVSPENQKSITKDGKEAIVPTTSSTSTSSSATSTTSSSTSSTTTTSSTSNSSTPGSTMGCINGGNSILSFPIRVVSKVDHIKKDPNGVCEKKQTFIDILTDRLSSLENLHLTQSALLSNMLKERGIPESEYSFSEYSEPELISCAFSTSPPSSPFSISGGGGSGGIPSQSGIIKKHKKPSGSSGYGDNKNTAERFLECFNRVIKVYKEHYGKKSFELSKFISSLDNDEKNILVDLLESFTFDESSQVKSLDNNDHCEDCNCETCPYKQQAEQFMLLSPVICFPSPAIKSSNNTNNTNNTNNTNNNTVVTI
Protein: F9D12.8 protein (TRAF-like family protein) (O81493)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDSHKWSLGFTLLAFLFITSSSAELIIKQVTQGRGIEYNNSYSLTSNLGVTTRELRDERPSSKIVTITSFSVIKDRGEPYESSIFEAAGYKWRLVLYVKGNPKGGINNHISLYARIEETETLPRGWEVNVDLKLFVHNRKLKKYLSVTDGTVKRYNDAKKEWGFTQLISLPTFYNANEGYLVQDTASFGAEIFIVNPTEKQEKVTFISNPPDNVFTWKILRFSTLEDKFYYSDDFLVGDRYWRLGFNPKGSGGGRPHALPIFLYAQGHKANAVVTNTWGAVNLRLKNQRSSNHKQLYSAAWYPIRSDYGVGVNNIILMSELKDASKGYMVNDAIIFEAEMVKVSVTNIVSV
Protein: Mnn4p (A0A1D8PMM6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Glycolipid 2-alpha-mannosyltransferase 2
- Adaecp
- Initiation-specific alpha-1,6-mannosyltransferase
Sequence:
MSNTIPQYFIRIFNLIFSARRKNFQLALISGLLFFGSFVILSTTSYSKKFNYFDDLILKIYDYNYLTNNYNIDYLAKNDPEAYFNVKVQQIVDEKKQHDLESKFWSLDTKINDDQATLQIPAYFTYNKPRDNKNLEDSEQSSKPVEKPLIQPFDPRFTLAMYYYYLDQQMTTAHHDSSSSSSENSITVPFNWYDWVDMSVLNKYLLAPNKDKPDCSILDAHEDARKIETEKKKMEKLAKQWDENKRKAEEEKKKAEEDKKKEEEEKKKAEEEEKQRHEQEKQALEEDKKKLEEEKKKIEEEKNKLQEQQQQQQEEKANDGNQKHSKFVKRDDEIKMSTSQDKSDSDSDRAKIDMTTFFNEAFEKLSDEDKASVAKDVEDAVKKITQPSSWCVPNAKLSIDHSDKQIVHPGFNVFKSPGRTTPQKAIIAGKSFLYSYAPPPSSILFLTSEGSYSVNVQHSAPLLRNGIPESYLANNNFDVSLNVLQQLHKLKKNHKPDTAKVINDYLLHIPKESFKYDPDSIIFDYTKRLDKGEKLTIKELKYLQSLEYSKDKVAHGGPPKYFAESRLIGTTVGDHYDWRFFNGVQFGTVDQSLTLHRLIRTWLSFTRKSGITTWIAHGSLLSWYWNGMAFPWDNDIDVQVPIMDLHKLSLQFNQTIVVEDPEDGFGRYFLDIGSFITLREKGNGNNNIDARFIDIDTGLYIDITALALSNSETPKSDLAELPKNFEIKDNNYKPANELLQIYNCRNNHFNSYDELSPLMKSSVEGEIGYIPSRYSTILTREYRSGLSSNSHGGYIFIAKLRLWVKEEDLYYFIKHRDQWTKYHSFNTKLSQDPSNTLLQDYSYLMSEQEYENLQYSTDLEHDNPFKKTKKPLELKNSELEKLKHMNESELLQFLNNDDILIQFFNAKEFTSFHESEIMQLTFGKSTAKLMSSAIDFPPIKYEPYLYKLNHDLDTFENKVDRYLALQDAYQQEHNNSPSGSSDNGFMEIEEDLDFAF
Protein: PDGF- and VEGF-receptor related, isoform K (EC 2.7.10.1) (M9MRE1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MAMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIGNGHIDKDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAPEEIPMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKEQRRY
Protein: Kinesin-like protein (F1QV34)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Intraflagellar transport 88 homolog.
- Kinesin family member 11
- Kinesin-like protein
- Intraflagellar transport protein 46 homolog
- Kinesin family member 15
- Intraflagellar transport 52 homolog
- Kinetochore protein NDC80 homolog
- Intraflagellar transport protein 20 homolog
- Transportin 1.
- Abnormal spindle-like microcephaly-associated protein
Sequence:
MASESVKVVVRCRPLNNREKAMNCKIVVSVDSTHCQCFIKKPGDTEEPPKQFTFDGTYYINHSTEEVYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGVPDPPSQRGIIPRAFEHIFETIQCAENTKFLVRASYLEIYKEEIRDLLGKDIKQKMELKEHPERGVYVRDLTMQTVHSVGECERVMDLGWRNRSVGYTLMNKDSSRSHSIFTIHLEICSIDTAGDEHLRAGKLNLVDLAGSERQSKTGATGDRLQEATKINLSLSALGNVISALVDGRSKYIPYRDSKLTRLLQDSLGGNTRTLMVACLSPADNNYEESISTLRYANRAKSIQNRPRINEDPKDALLREYQEEIKKLRALISGQLGSGNLSSFLAGQKSGEASAVVSRPQSNTSESEAEKDKIKEEYEKKLARLQAEYDAEQESKVKLQEDIAALRTSYETRLSSLERSRGSRTHTTGGVHLQQHKEEPITASAASQEQAKIDHSESEERPSSVDATVKGAASGESQILDSVVVDIPGQLDQKLALERLQQLEQEFVGGEQVRNEELKQRHKQRKTLADQRKKQLIEALNQSSEDGDSVLLNVYDSIQEEVHAKSRHLENTQKKLKAAKLEIRDLQAEFEMERNDYLATIRRLEREGQLLQGILERMVSLVRRDCNYSNLDRLRKEAVWDEEGGTWRLPDVLVQKTTLPAVPPSGVIAPGRLSARRNSASDLADPFVQEEEQDRYKEMLNRSDSEHIATNYFRPKRSSQLLATDSVKNSMNFSSSVSNGSAHQSSSGSGLSALTVESILPRPFRLESLGVPASHGKVKRKKSKTLISTDY
Protein: Hepatocyte growth factor activator (Q800Y7)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
GLQIGNSWYRMSQNKELAIAEGKREDKDHLCSTTHNYDRDRKWGYCTLLSTEHSDYCANNPCQNGGTCFLAHGRRTYHCACPEEFTGRDCQMKKCFDDSLYEFFDVDMRWSRVKQGSVEQCICVDGQMECLRVEHKSCVHDPCMNGGECKMIASSGKTVCDCKGPFVGKYCNIVPNHHCYRGNGTEYRGTAKTTISGHSCLPWNSDLLYRELHVDSVEKAVQLGLGPFSYCRNPDEDEKPWCYIMKDNSLSWEYCNITSCASRERRPPVLEDIDTFAVPRRPCGRRHKKRSFVRPRIIGGSSSLPGSHPWTAAIYIGESFCAGTLIQTCWVVSAAHCFANSPQKSSIKVVLGQHFFNRTTDVTQTFEIEKYILYPQYSVFRPTEHDIALIKLKKNGQRCAVKSQFVQPICLPESNTVFPDQFKCQISGWGHKHENITGYSDVLQETLIPIIPEEKCRSPEIYGTEISENMFCAGYFDSKSDACQGDSGGPLACENNEISYLYGVISWGDGCGRVNKPGVYTRVPNYVNWINERIAPRKTS
Protein: P2X receptor E (P2XE) (Q54JH4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents evoked by intracellular ATP. ATP analog beta, gamma-imido-ATP is a weak partial agonist of p2xE. Exclusively selective for ATP over other nucleotides. Insensitive to copper and P2 receptor antagonists PPADS and suramin but strongly inhibited by sodium ions. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. Permeable to calcium ions, but not chloride.
Subcellular location: Contractile vacuole membrane {ECO:0000269|PubMed:19833731}. Note=Ligand binding domain within the lumen of the vacuole.
Interaction partners:
- Probable serine/threonine-protein kinase DDB_G0277165
- 14-3-3-like protein
Sequence:
MNFRNIDWDSLFSYSTIKIVRIRDKRLGILHFAFLIGIILYIIVGTIFLQKKYLVLESPIGSIRTSLMAPSVKPTDLPYCLKNGTDTSYDGYPNKPCQYWDEYLVLYPPSEESSMFITTRCTQETQSTVNGCNLSEPTCVYNTTSSSDFYIANVENFTILLDHTLSAPSLGIQYNGAQLNGQLLDTDGNPMSLPPPNIVGVKGSPDIMSLQGVLTAAGVESLDSQGLANKSRTIRDDGILILCFITYSNTYTYNTGNYHYTYQFKLVQNTKYKIVEPVFTKDVEDRYIFDRHGVRIIFIQTGQLGQFDFQTMLLTFVSGIGLVTAASLIVDIIATRIMPQRSRYQELKFQDSSINNTQKTPTNDHTPLLKDNEDTINENSYQNNSYEK
Protein: Tubulin alpha chain (B5DH02)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MRECISMHVGQAGAQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRTRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVADITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNSAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGTDSIGEEDEEGEEY
Protein: Leishmanolysin (EC 3.4.24.36) (Q4QHH2)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Leishmanolysin
Sequence:
MSVDSSSTHRRRCVAARLVRLAAAGAAVTVAVGTAAAWAHAGALQHRCVHDAMQARVRQSVADHHKAPGAVSAVGLPYVTLDAAHTAAAADPRPGSARSVVRDVNWGALRIAVSTEDLTDPAYHCARVGQHVKDHAGAIVTCTAEDILTNEKRDILVKHLIPQAVQLHTERLKVQQVQGKWKVTDMVGDICGDFKVPQAHITEGFSNTDFVMYVASVPSEEGVLAWATTCQTFSDGHPAVGVINIPAANIASRYDQLVTRVVTHEMAHALGFSGPFFKDARIVASVPNVRGKNFDVPVINSSTAVAKAREQYGCDTLEYLEVEDQGGAGSAGSHIKMRNAQDELMAPAAAAGYYTALTMAIFQDLGFYQADFSKAEVMPWGQNAGCAFLTNKCMEQSVTQWPAMFCNESEDAIRCPTSRLSLGACGVTRHPGLPPYWQYFTDPSLAGLSAFMDYCPVVVPYSDGSCTQRASEAHASLLPFNVFSDAARCIDGAFRPKATDGIVKSYAGLCANVQCDTATRTYSVQVHGSNDYTNCTPGLRVELSTVSNAFEGGGYITCPPYVEVCQGNVQAAKDGGNTAAGRRGPRAAATALLVAALLAVAL
Protein: Protein transport protein sec1 (Q54QC8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the vesicle trafficking. Binds syntaxins (By similarity).
Interaction partners:
- t-SNARE family protein
- Exocyst complex component 3
- Synaptobrevin-B
- Synaptobrevin-A
- Exocyst complex component 6
- t-SNARE family protein
- Uncharacterized protein
- Vesicle-fusing ATPase
- Exocyst complex component 4
- Exocyst complex component 5
Sequence:
MATSLRELCKDRILNEMVRTITPEASNGWKALIVDQDSLRVISACCGMFDIMEEKVTVVEKIDNPRQRLPNLEAIYFLTPTAQSIDLLINDFKKKSSPHYLAIHLFLTSKLPEVEFKKLSASLAVHRIKTFKEINLEFLAIESQAFHLDQNNTLFQLFSPDSIDPTEEQAKIATRLVSLCVSLNECPIIRFSRSHPVSAMIAGFTQEKLDNVMRTVKSFKPNDDRSTLLILDRTQDPLAPLIHEFSYQAMVYDLFDIENDKFSFDTVTNAGATLKKDVLLGETDYMWSGLRHQHIADVSTNLTTRLDEFLKTNQVSQYGQHTGSLKEAGEVVRSLPQYQEMMGKYSVHINLADRASAKFPELEQLAYLEQDLATGEDANGNSPKNVTGRLSNYLSDFSAEKYNKIRLLMMYIISQDGIKEEDRRRLMEMAGISQSEQNAFTNLRYLGVTLMKGAKGKKPISPPKNRKSESGNVPYEVSRYVPVVKDIAENIINETLPSTDFPFVKEEPIARATNAPVSKVSLKGKSKQPRWADPNVQVEETKYSGSKLIIFVIGGMTFSEMRSIYELSSHYKKNIYIGSTNILLPKKYIDQLLTLKNE
Protein: CRISPR-associated endonuclease Cas1 (EC 3.1.-.-) (Q02ML7)
Organism: Pseudomonas aeruginosa (strain UCBPP-PA14)
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Acts as a ss- and dsDNA-specific endonuclease.
Interaction partners:
Sequence:
MDDISPSELKTILHSKRANLYYLQHCRVLVNGGRVEYVTDEGRHSHYWNIPIANTTSLLLGTGTSITQAAMRELARAGVLVGFCGGGGTPLFSANEVDVEVSWLTPQSEYRPTEYLQRWVGFWFDEEKRLVAARHFQRARLERIRHSWLEDRVLRDAGFAVDATALAVAVEDSARALEQAPNHEHLLTEEARLSKRLFKLAAQATRYGEFVRAKRGSGGDPANRFLDHGNYLAYGLAATATWVLGIPHGLAVLHGKTRRGGLVFDVADLIKDSLILPQAFLSAMRGDEEQDFRQACLDNLSRAQALDFMIDTLKDVAQRSTVSA
Protein: Auxin-responsive protein SAUR36 (Protein SMALL AUXIN UP RNA 36) (B7F8P5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the negative regulation of organ growth. May act as a negative regulator of auxin synthesis and transport.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19700562}.
Interaction partners:
Sequence:
MPLQTIHKLKHQYTHNKSSSHQKKHTMINPKRLVHLAKKWQHMAALGRRRLTITGATKEGNLRCSSAIADKGHCIIYTADGERFGVPLTYLSTTVFGELLRLSEDEFGFTGEEKITLPCEAAVMEYVMCLLRRKPSEEVEQAVVSSVVMPCNYKSSTSMVSVNLSQSLAIF