wanglab/gogpt-training-data huggingface dataset:
Protein: ALBINO3-like protein 1, chloroplastic (Arabidopsis thaliana envelope membrane integrase) (Protein ALBINA 4) (Ath4) (Protein ARTEMIS) (Suppressor of tic40 protein 1) (Q9FYL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the insertion of some light harvesting chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid membrane. Plays a role in the accumulation of some cytochrome b6f components in the thylakoid membrane. Required for the assembly and/or stability of the F(1)F(0) ATP synthase in chloroplast thylakoid membranes. Functions to stabilize or promote assembly of F(1) during its attachment to the membrane-embedded F(0) part. Participates with STIC2 in thylakoid protein targeting. May function with a specific subset of thylakoidal proteins.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:16595657, ECO:0000269|PubMed:28684427}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nucleoid-associated protein At2g24020, chloroplastic
- Signal recognition particle subunit SRP54, chloroplastic
- Signal recognition particle 43 kDa protein, chloroplastic
- Preprotein translocase subunit SCY1, chloroplastic
- Cell division protein FtsY homolog, chloroplastic
- Protein CONSERVED ONLY IN THE GREEN LINEAGE 160, chloroplastic
- Preprotein translocase subunit SCY2, chloroplastic
- Large ribosomal subunit protein mL45
- Membrane-associated protein VIPP1, chloroplastic
- Protein TIC 40, chloroplastic
Sequence:
MSSTISLKPTHLILSSFSTGKVLQFRRSRFSHTPSSSSSRYRTLVAQLGFRPDSFDFIKDHAENLLYTIADAAVSSSETFESVAGTTTKTTQSNDWFSGIANYMETILKVLKDGLSTVHVPYSYGFAIILLTVLVKAATFPLTKKQVESAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADEGLLTEGFFWIPSLAGPTTVAARQNGSGISWLFPFIEGHPPLGWPDTLAYLVLPLLLVFSQYLSIQIMQSSQSNDPAMKSSQAVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAKNPVEKFTNLVTKEDKTQQIEKSFSEPLVQKSVSELKIPREKGGEKVTPECPKPGERFRLLKEQEAKRRREKEERQKAEAALSNQNTDKAHEQDEKSDTAIVAEDDKKTELSAVDETSDGTVAVNGKPSIQKDETTNGTFGIGHDTEQQHSHETEKR
Protein: Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) (O75396)
Organism: Homo sapiens (Human)
Function: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:Q4KM74, ECO:0000269|PubMed:17081065}.
Interaction partners:
- Golgi SNAP receptor complex member 2
- Syntaxin-4
- Syntaxin-18
- BET1 homolog
- Syntaxin-5
- Vesicle transport protein USE1
- Golgi SNAP receptor complex member 1
- Sec1 family domain-containing protein 1
- Synaptobrevin homolog YKT6
- Protein transport protein Sec23A
Sequence:
MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTFIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL
Protein: Metastasis-associated 1 family, member 3 (Metastasis-associated protein MTA3 isoform X1) (E7EY65)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAANMYRVGDYVFFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISQSLIQLADKHAKDLEEEKESPPESDLTEKQKHQLRHRELFLSRQYESLPATHIRGKCSVALLNETEVVLSYLEKEDTFFYSLVYDPTQKTLLADKGEIRVGPRFQADVPEMLQEGEADDRDQSKLEMKMWDPECPLTNKQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHRHGYDLSSALSVLVPQGGPVLCRDEMEEWSSSEANLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYNKPNPNQISVSNGKMATVNGAAAGTGSFHTAGGGRACESCFAVQSAQWYSWGPPNMQCRLCVSCWMYWKKYGGLKMPSRAEGAEEKTPPSPAPNESRSRGHCARQSSHMVPIRNSGSPKSSMKTKQAFLLQATRLTKLARHMCRDLIRLRRAARRPFVPINCGAIKAEYMIRVSEGMTGRPLKPKSSPRSTLTSVLQYLESRPATHVQRPHRTPGLQVQPPRRLLSSLPSHGPLGMLGKRSYHHHSRVESAERRAGATGQENPAHIVGPILQHNGSSTGGSSLRGSGLMLRKRRPNWIDAPDDSFFLVSRETRKARRMLSRSQLRRACRQPCEQISLRRVPQGPSQVPILAPPHPSLRMRGPIVIHD
Protein: ATP-dependent helicase ULS1 (EC 3.6.4.-) (Role in silencing protein 1) (Ubiquitin ligase for SUMO conjugates protein 1) (Q08562)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:18603780}.
Interaction partners:
- Ubiquitin-like protein SMT3
- Protein STU2
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8
- ATP-dependent helicase SGS1
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5
- Postreplication repair E3 ubiquitin-protein ligase RAD18
- ATP-dependent DNA helicase SRS2
- Crossover junction endonuclease MUS81
- DNA repair protein RAD51
- Transcription factor TOG1
Sequence:
MAAVPTIDLTLADSDNEDIFHSFSSSTSVDKIDIRKENGKLRMAGLEVAQSNDDAARQAFHVFKTNISNNETFDTILSKSKTITDSTFNNEKSSNEVKQQQVLKEETMGSSNDEKKTQESSPSAEMIKLFYENDDVPLSDSFKQKEEGKRINQDEQVKENICGISSSYVSKDYDGVEDDFEPNTCQDSNLDFQEEKLNLNNKPSQQQFSDPETKDNSLKSENKDQIKGVTTTSYRDLPIESSAFQDSETQNNSKNTIPNIVNEKRTPALPSNLSSVESSLKNETAKVEGKTTVRLPGLQNNVALLEQEQSELFKHFSEQPVDISDFGRKIKRKHSGDFADNKILKRPILPSKNMDHTTHNSHDSEQKNSSIIILSDEDESGAGINDIESPLKVSEPNTADALRSSVPEVISLLDLPNIDLNNSVIKEASGSNSIPTSETDAQSSSSSVLQGTIMTEQATQSSQHECNSSLDTLKKNHQKLLKDLNSRESELRNALSCCKTNSEILRRKLSRREKEVSDAEKHWQLLLTSMARGGRTISSTQQILVDEAENQLNKLKEKRQLTKSKLDSINLKMYNYNEQWKSFVHSKNINLQKSLAALERSARDSKASATVNKRNECLAEKEKLDQMLKEGTLSFSTYKQLTGEIQQKLNDLKLGDQRTTDINSVLPIVRQPLAKRDLFIKSIDTAKDLLAKNTSRTEMTKRILYRHLDNLVSYKNFFEDGRSLIDINRRHVAHESAQILFTNGVKMPIVFETLQDYGIKFSNPAIVNPDRRAQYFKSIEVARDLISKSTRSEDAKRKITRFLNIIEEFRKDIDTGFPPTPLKREGVGKAVVGLRQQGLKMDRLYENLRRYKIPITSEELLQQSYLFPVNADQRPPSNWNIVENTEDTSSTANDLSMQDEFHISNMHAAEDQEQIRALLENVKQSESIIDGEALTPEDMTVNLLKHQRLGLHWLLQVENSAKKGGLLADDMGLGKTIQAIALMLANRSEESKCKTNLIVAPVSVLRVWKGELETKVKKRAKFTTFIFGGSGNGKVKHWRDLARYDAVLVSYQTLANEFKKHWPKKLDGEQNQLPAVPHIQALNRLKTSNEYYSPFFCNDSTFYRILLDEGQNIKNKNTRASKACCTINGMYRWVLSGTPIQNSMDELYSLIRFLRIPPYHKEQRFKLDIGRFFQRNKQYQYDNEDRKNALRKVRVLLNAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELKFYTALESKNQALAKKLLNNSTRGSYSSVLTLLLRLRQACCHSELVVMGEKKAEGTKVANGKSFEDDWLRLYYKITHMSGEAQAQVITSMNSMTCFWCMEQLEPEAMSVLTGCGHLICDTCIEPFIEESSMLPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLYDQVINQGFTEEDLHAEYLSEMEKQKIQQKNVYVPNFESLEPSTKIEQCIQVIQRVFDESATEKIIIFSQFTTFFEILEHFLKNKLNFPYLKYIGSMNAQRRSDVINEFYRDPEKRILLISMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRCYRISQTKKVQVHKLFIKDSVEDRISELQKRKKEMVDSAMDPGKIKEVNSLGRRELGFLFGLNAL
Protein: Myosin, heavy chain 15 (A0A0G2JY53)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Myosin light chain 1/3, skeletal muscle isoform
- Myosin regulatory light chain RLC-A
- Myosin light chain 4
- Myosin light chain 3
- Myosin regulatory light polypeptide 9
- Myosin regulatory light chain 12B
- Myosin light chain 6B like 1
- Myosin light polypeptide 6
- Myosin light chain 6B like 1
Sequence:
MDLSEFGDAAAFLRRNRAEPWFQPPAFDGKKKCWVPDGKNAYTEAEVKESSGDGHVIVETRDGESLRIREDEIQQMNPAELEMIEDLSMLLYINEGSVLHTLRKRYDHWMIYTYSGLFCVAINPYKWLPVYQKEVMAAYKRKRRSEAPPHIFAVANHAFQDMLRNGENQSILFTGESGSGKTVNTKMIIQYFATMAATSEPKKKLGNLEDQIVQMNPILEAFGNAKTLRNDNSSRFGKFIRMYFGVRGTLSFADIQIYFLEKSRVVYQQPGERNYHIFYQILSGKQELQDMLLVSTNPSDFHICSCGVVAVENLDDAKGFLATEKAIDVLGFLPDEKFGCYKLVGAIMHFGNLKFRQNPREEQLEADGTENADKAALLMGINASELLKGLIYPRIKVGNEYVTRSQNIQQVTYAVGALSKSIYERMFKWLVARMNQVLDAKVTSHFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQQLFVLEQEECRKEGLDWMSIDYGLDLQACIDLIEKPMGILSILEEECMLPKATDNTFKTKLFAHHFGKSAYFQKPTAPEKNFEVHFELAHYAGVVPYDISGWIGKNKELLNETVVALLQKSSNKVLASLFTNNTIAGSFGEKPRRKATSFQLITSLHKESINKLMADLKSTAPHFVRCINPNENKIPGVMDPFWVLQQLRCNGVLEGTRVCCKAFPIRMLYDDFKQRYCILNPRIFSKSKFVNIRKATEEVLALLEIDQSQYQCGVTKVFFKARILDRLEERRDEKISKVFTLFQARARGKLMRITFQKILEERDALALIQENIRAFIAVKTWPWMGLFFKVKPLAKSVGAGEEIAGLKEECAQLQKSLETSESQREELKTKQVSLVQERNDLLLQLQAEQETLANSEELCESLIKSKIELEAKIKELSRRVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKSEKAKCAAEHKVRNLTEEVHSLHEDVSKLTRAMQAAQEAQQQTQEHLHIEEEKLSNVSKVNQKLSQQVDALEGDLERERKARMKCEREKHKLEGELKLNQEGAENLESSRQQLIEQLRKKEFEMGQMNSKVENEKNLVSQLQKTVKELQTQILNLKEELESERTIRAKVERERGDLAQDLEDLNERLEEAGGTSLAQMEITRQQEARFQKLRHDMEETTRHFEATSVSLKRRHAENVAELEGQVEHLQQVRQVLDQEKSDLQLQVDDLLTRVDQMARAKANAEKLCGLYERRLNEANTKLDEATQLAKDLTSQRTKLQNESGEFFKRLEEKEALISQLSREKSNLILQVEELRVQLEEESKSQSALAHALQSTKHDYDLLREQYEEEQEVKSELHRALSKGNKETVQWRTKYEHDAMQRTEDLEEAKKKLAIRLQEAAEAMEVSNAKNASLERARHRLQLELGDALSDLGKARSVAAALGQKQQHSDKALASWKQKQEEAQELLQASQKEARALSSEVLMLRQACEESNEAQETLKRQNQDLQERICCLTNQVREGIKNLTEVEKAKKLIEQEKTEIQARLEEAEGALERNESKILRFQLDLSEAKAELGRKLSEKEDEAGRLREKHQQALGSLQSSLDSEASSRIEATKMRKKIEGDLKEMEIQLCTANRQVSQTTRALGQLQSQMKDLQQHLDDSIYQNKDLKDQVALAEQRNILLQSELEELRSLQEQTERGRKLAEKELLEATERISLFHTQNASLLSQKKKLEADVAQAQKEAGEMLQACQKAEEKAKKTAAEAANMWEELKKEQDTNAHLERTRKNMEQTIKDLQKRLDEAEQTAVVGSKKQIQKLESRVRDLEGELESEVRRSAEAQREARRLERGIKELTYQAEEDKKNLSRMQALSDKLQLKVQSYKQQVEAVEAQANQYLSKYKKQQHELNEAKERAEAAESQVNKLRARAKELERKVREE
Protein: Katanin p80 WD40 repeat-containing subunit B1 homolog KTN80.4 (Q8H0T9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May participate in a complex which severs microtubules in an ATP-dependent manner (By similarity). This activity may promote rapid reorganization of cellular microtubule arrays (By similarity). Confers precision to microtubule (MT) severing by specific targeting of KTN1 to MT cleavage sites such as crossover or branching nucleation sites. Together with other KTN80s, regulates cell elongation by modulating MT organization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:28978669}. Note=Present in dynamic discrete particles specifically localized to microtubule (MT) crossovers and branching nucleation sites. {ECO:0000269|PubMed:28978669}.
Interaction partners:
- Katanin p60 ATPase-containing subunit A1
- AT2G34560 protein
- 1-aminocyclopropane-1-carboxylate oxidase homolog 3
- Protein PHYTOCHROME-DEPENDENT LATE-FLOWERING
- Transducin/WD40 repeat-like superfamily protein
- Actin-interacting protein 1-2
- THO complex subunit 6
- Guanine nucleotide-binding protein subunit beta
- Cell division cycle 20.5, cofactor of APC complex
- Protein ROOT INITIATION DEFECTIVE 3
Sequence:
MTTKRAYKLQEFVAHSAAVNCLKIGRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEVLVAAGAASGTIKLWDLEEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWVVSGGEDNIVKVWDLTAGKLLTEFKSHEGQIQSLDFHPHEFLLATGSADRTVKFWDLETFELIGSGGPETAGVRCLSFNPDGKTVLCGLQESLKIFSWEPIRCHDGVDVGWSRLSDMNVHEGKLLGCSYNQSCVGVWVVDLSRTEPCMAGDTAQSNGHPEKRSCSGRDPVVLNDNNSKTVLGKLSVSQNVDPLLKETKSLGRLSVSQNSDPSTKETKSIGRSSTSQNSESSMKESKPLGRLSVSQNSDVSKESRTFSSTGSLPGTPHRVSSTNVSKATSGVSTAVSNAATSRRNFTKANPKANPVNKAADFAPVIVPRADPRIEQATESRAELDIIARTMPYSLQAADSRRSPSSRNNPDLPDASVLEMSESQPVEPNNIPDGGTLPGGKVGMRGATERSINDFRYKRYGRSNSRSRMGSPPRNHDENYDLVSHRSNRDPSPTESQKGGRFQSLVINRERRGRFSNFEGPVSNFSSGNMPAPNIRPSNMFKQRGNHMPVEQGIDSPSEENIVEDIMGKHNQFVSSMQSRLAKLQVVRRYWERNDVKNSIGSIEKMADNAVTADVLGIITERNEILTLDNCTSLLPLLTALLGSGMDQHLSVSLDLLLKLVRLYGSPIYSSLSAPASVGVDIEAEQRIERYSRCFVELEKVKACLPSLARRGGLVAKSVLELNLAFQEVSS
Protein: Non-muscle myosin heavy chain II (Q22869)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTSSRQKDDEIDQLRAKTDFLNPSISADWAKKKLMWVPSEKDGFALGAVIGEPHADGTIDIELMETGERQRVSSDDYQKPNPPKYDKCEDMSMLTCLNEASVLHNLKQRYFSNLYYTYSGLFCVVINPYKRIPIYTDTIAEQFKCKKRKEMPPHIFAVADEAYRSMLQERDDQSILCTGESGAGKTENTKKVIQYLAYVANRSMVKNRKTSVDLDTSTNRIMGQLEEQLLQANPILEAFGNSKTVKNDNSSRFGKFIRVHFDSTGCISGANIEFYLLEKSRVLKQAPNERSFHIFYQLLKGLSKVQREHYLLEDSLSKYKFVSNGDSKLAGVDDGAEMKETLNAMSIMGLNDEEIGGILRVVSAVMLFGNLEFSHENKNNDQAVLLNDAVAQKIASLLGVNVTELMRAFLKPKIKVQRDLVHRAQSVDQVNFSVGAIAKASYERLFRWLVHRLNKSLDRTRQQSVSFIGILDIAGFEIFETNSFEQLCINYTNEKLQQLFNNTMFVREQQEYLDEGLEWKFLDFGLNLQPTIDLIDKPMGIMSTLDDVCLFPQGNDQSFVQRLNNTHSQHPKYVVPEIRSRSDFAVVHYAGRVDYQSEGWRVKNMDPLNENVIDVLKTSKESLIVDMWKDIADVCSLSAADSTSDTGVFGSRVPKKGMFRTVSQLYKEQLARLMSTLNNTNPHFVRCIIPNHEKKHGVLNAHLVLDQLRCNGVLEGIRICRQGFPTRLPFQEFRQRYEKLLAPDVNPAGFMDGKNAVYRIVQYLEVDANLFRIGQSKIFFRSGVIAEFEEMRDQKLSALIESFQAQCRGWLGRRVMVRRREQEVAIKILQRNGLAWMRLREWQWWRLLTKVKPLLEVTNKDELIAEREQELKVTAEKLRRSEVFISDYKQQMEKMDEERLVLKTRLDAESSERAEIFEERSRMAARRDELEGILEEVSKRLEIEEQKAKKADSESRKLTEMVRHLEENLEDEERSRQKLLLEKNSIESRLKELEAQGLELEDSGNKLSKEKKALEERCEDLSSRLIDEVERSKQLVKAKARLEATVAEINDELEKEKQQRHNAETARRAAETQLREEQESCLEKTRKAEELTNQLMRKESELSQISIRNDEELAARQQLEREIREIRAQLDDAIEETNKEQAARQKAEKARRDMAEELESYKQELEESNDKTVLHSQLKAKRDEEYAHLQKQLEETVKSSEEVVEEMKAQNQKKIEELNETIDQLKRQKISADKAKSSAESDNENFRAELSNIASARLEAEKKRKAAETSLMEKDHKMREMQSNLDDLMAKLSKMNNELESIQKAKSADETLNSNLLKKNASLDMQLSELTEASEEDRRTRATLNNKIRQLEEDLAVAVEARDDALDAQEKIEKEVKEVKSLLAEARKKLDEENREVMEELRKKKEKELSAEKERADMAEQARDKAERAKKKAIQEAEDVQKELTDVVAATREMERKMRKFDQQLAEERNNTLLAQQERDMAHQMLRDAETKALVLSNELSEKKDIVDQLEKDKRTLKLEIDNLASTKDDAGKNVYELEKTKRRLDEELSRAEQQIIELEDALQLADDARSRVEVNMQAMRSEFERQLASREEDEDDRKKGLTSKIRNLTEELESEQRARQAAIANKKKIESQISELTEKNEASLRQIEDLSRQLRKAQLGWKDLQLDVTEARAAMEDALAGQRDAEKRARASEDEIKRLTADIQAVSSSKRKAEAERDELIEEVSSLRASSFSNEEKRRLEAKVIDLEDQLDEEASANELAQEKVRKSQQQLEQMTADLAMERSVCERTESDKIALERANRDLKQQLQDAENTAVARLRTQINVAEAKVSSLEQQLSLEEQDKMRQGRTLRRMETKMAEMQQMLEEEKRQGESNRQAVDRQNARIRQLRTQLEDTEAERDRLTNKLKDERRRAEEMTDLNETLSRDVSLLKQRETTARRTPGLIGHRESRRFGSNTSLARDEFRGSALTNEMSPSDRPASRLTSGTGSQLGNTDEDRDSVRN
Protein: Calcium-binding protein CP1 (NaCl-inducible Ca2+-binding protein) (AtCP1) (Q9FDX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds calcium in vitro.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:9678579}.
Interaction partners:
- Plasma membrane-associated cation-binding protein 1
- Mitogen-activated protein kinase 8
- Kinesin-like protein KIN-14E
- Calmodulin-binding transcription activator 3
- Calcium-binding protein CML42
- Two pore calcium channel protein 1
- CDPK-related kinase 1
- Calcium-binding protein CML37
- Calreticulin-1
- Calcium-dependent protein kinase 1
Sequence:
MCPSGRIAIPITTTANPNFRPAFEIIDTDHDGKISSDDLRAFYAGIPSGENNDETMIGTMISVADANKDGFVEFDEFEKVLETTPFSRSGNGGDDGLMKDVFKVMDKDGDGRLSYGDLKSYMDSAGLAVTDDEIKSMIRLAGGDLNDGVSFDGLLKIFGC
Protein: Synaptotagmin-11 (Synaptotagmin XI) (SytXI) (Q9R0N3)
Organism: Mus musculus (Mouse)
Function: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane. Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:30808661}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:30808661}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28686317}; Single-pass membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:28686317}; Single-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:26450452, ECO:0000269|PubMed:28686317}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:28686317}. Cell projection, axon {ECO:0000269|PubMed:30808661}. Cell projection, dendrite {ECO:0000269|PubMed:30808661}. Postsynaptic density {ECO:0000269|PubMed:30808661}. Recycling endosome membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Perikaryon {ECO:0000250|UniProtKB:O08835}. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions (PubMed:30808661). In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (PubMed:23303671, PubMed:28686317). {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:28686317, ECO:0000269|PubMed:30808661}.
Interaction partners:
- Vesicle-associated membrane protein 2
- E3 ubiquitin-protein ligase parkin
- Synaptotagmin-1
- Synaptotagmin-2
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 8
Sequence:
MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPRRESGRGNLLINAESGLLSHDKDPRGPSPASCMDQLPIKRDYGEELRSPMTSLTPGESKATSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPVFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPIAKWHSLSEY
Protein: E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (D3ZVH5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleoplasm {ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleolus {ECO:0000256|PIRNR:PIRNR006748}.
Interaction partners:
Sequence:
MCNTNMSVSTEGAAGTSQIPASEQETLIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN
Protein: LP07893p (Q5BI54)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLKETTKKSTPSATTSAHSHKTVPPSGGLLSTLHISPSLHQLPLSVQLQHQLHHQQQQQQQQPLQHPLPHQPHQLQHLLHLQHQQQQQQQHQQRCSSVGSTSSSGTCETDRSYQSAGSCSSALSPAGGIGGIGGIMPGLAGATGDALGPAGAVAGSPGDEASAAAALAANIAESFTFLQQHAAHHFRDILYAAHMLGRGYYQPAGPLISPHVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQSQSQGQSHGHAHSHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGYPPNYYAPYPGEVMCYSPPTYPPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYYQHAGPPPPHELYEQQPPPPPVSSGSVSGPAQQQPPTSSPASVGAAGAGTAGAPSGSQLVPAHQQQHQQQHLEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIISNIDQSSSCSSSMLLSATSNSNIGGGSSSSSSSSSSTTLPACSSATTTTTASALTTSRGPVKNVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPPESYCASDEKLLDDQEQEAELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAKLEAEPEMPFVLKAEIKAETKIKIEHDGEAQASTHISQLPDLKPTIKTEPEQELEQEAASVPSVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNLLALSSGNKKKKKK
Protein: Orchestin (Q9XYT4)
Organism: Cryptorchestia cavimana (Amphipod) (Orchestia cavimana)
Function: Plays a role in cuticle calcification. May induce precipitation of the calcium stored in the posterior caeca as calcium carbonate.
Subcellular location: Secreted {ECO:0000269|PubMed:15099573}. Note=During the premolt period, localizes to microvilli-rich apical regions and to the subnuclear region. During the postmolt period, localizes to the intercellular space, basal region of cells and calcium reabsorption spherules.
Interaction partners:
Sequence:
MNKVFIIGVCLFIVSQAVLAVPWDSDESSDERLSDRSDESREEPRKLVVSDDDSREDSNESAEVRRRDDSRESEEEPRKLSADTSDEDSDDSQESPLDLFFKTLRDSKISRAQRAALLKALLSRYAGY
Protein: Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] (O43612)
Organism: Homo sapiens (Human)
Function: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
Subcellular location: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O55232}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O55232}. Synapse {ECO:0000250|UniProtKB:O55232}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250|UniProtKB:O55232}.
Interaction partners:
- Orexin receptor type 2
- Orexin/Hypocretin receptor type 1
- Pro-MCH
- HLA class II histocompatibility antigen, DQ beta 1 chain
- HLA class II histocompatibility antigen DQ alpha chain
- Leptin
- Pro-neuropeptide Y
- Oxidation resistance protein 1
- Pro-opiomelanocortin
- Agouti-related protein
Sequence:
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAAASVAPGGQSGI
Protein: ATPase get3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Golgi to ER traffic protein 3) (Guided entry of tail-anchored proteins 3) (Q9P7F8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000269|PubMed:16823372}. Endoplasmic reticulum {ECO:0000255|HAMAP-Rule:MF_03112}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein get1
- Golgi to ER traffic protein 4
- Small glutamine-rich tetratricopeptide repeat-containing protein 2
- Low molecular weight phosphotyrosine protein phosphatase
- UV excision repair protein rhp23
- Ubiquitin-ribosomal protein eL40B fusion protein
- Uncharacterized membrane protein C3B8.06
- Integral membrane protein sed5
- Sad1-interacting factor 1
- Protein transport protein sec22
Sequence:
MSFDPLPGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSKVRSSVLLISTDPAHNLSDAFGTKFGKDARKVPGFDNLSAMEIDPNLSIQEMTEQADQQNPNNPLSGMMQDLAFTIPGIDEALAFAEILKQIKSMEFDCVIFDTAPTGHTLRFLNFPTVLEKALGKLGGLSSRFGPMINQMGSIMGVNANEQDLFGKMESMRANISEVNKQFKNPDLTTFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLLLDPNTTCPQCMARRKMQQKYLAQIEELYEDFHVVKVPQVPAEVRGTEALKSFSEMLVKPYVYPTSGKE