wanglab/gogpt-training-data huggingface dataset:
Protein: Disease resistance protein RGA4 (Os11gRGA4) (SasRGA4) (F7J0M4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Disease resistance (R) protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Contribution of RGA5 is required to recognize the effector avirulence proteins AVR-Pia and AVR1-CO39 from M.oryzae. Acts as a constitutively active cell death inducer that is repressed by RGA5. Immune response triggered by the RGA4-RGA5 -mediated recognition of AVR1-CO39 confers resistance to X.oryzae pathovars.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25024433}.
Interaction partners:
Sequence:
MEAALLSGFIKAILPRLFSLVDDKHKLHKGVKGDIDFLIKELRMIVGAIDDDLSLDHPAAAAVQTLCMEDLRELAHGIEDCIDGVLYRAARDQQQSPVRRAVQAPKKLQRNLQLAQQLQRLKRMAAEANQRKQRYTAAAPGQHGQVYSSAAAQVDEPWPSCSSASDPRIHEADLVGVDADREELLEQLAERQPEQLKVIAIVGFCGLGKTALAAEAYNRETGGGRFERHAWVCAGHRSAREVLGELLRRLDADGRSFHGDSDAGQLCVDIRQQLEKNRYFIVIDDIQTEDQWKSIKSAFPTDKDIGSRIVVTTTIQSVANACCSANGYLHKMSRLDKNCSKQLLSKKACPERYSHYKQPDSAAILKKCDGQPLALVTIGEFLQANGWPTGPNCEDLCNRLHYHLENDKTLERMWRVLVRNYTSLPGHALKACLLYFGMFPSDHPIRRKSLLRRWLAEGFVEPLSSSSNIDSTAAFNVLMDRNIIEPINVSNNDKVKTCQTYGMMREFISHMSISQNFVTFFCDDKFVPKYVRRLSLHGDTVVNGDNFNGIDLSLVRSLAVFGEAGTTVLDFSKYQLLRVLDLEKCDDLKDDHLKEICNLVLLKYLSLGGNISKLPKDIAKLKDLEALDVRRSKVKIMPVEVFGLPCLIHLLGKFKLSDKVKQKTEVQEFLLKGKSNLQTLAGFASNGSEGFLHLMRYMNKLRKLKIWCTSSAGSTDWTDLREAIQQFILDEKEANIGTRSLSLHFSGCSEDAINSLKEPCYLSSLKLHGNFPQLPQFVTSLRGLKELCLSSTKFTTGLLEALSNLSYLQYLKLVADELEKFIIKVQGFPRLLRLCIVLQYPTFPVIEEGALPFLVTLQLLCKDLHGLSDIQIECFKHLQEVTLHSGVTPATRQEWVKAAKEHPNRPKVLLLKSVDTAESEHTDVDSVMEAVKSETTEYSIAPEGPEQVNNKMQLDHGLESSSVLNKQNNFADQSSSKDQLHYSFNNMGLSDVSCCE
Protein: Nibrin (M9NF67)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
Sequence:
MFVLTKDDEKFVLFPGKKVYTIGRLATDLIVAQDLSISRNHAQLLIQTEADGDDTLHIEDLGSRYGTFIFPKNSQKPRKVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTSNWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQPTNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGATCKDINSGVRKTFLTKSDVIVIQYVPSSQSQATESINSIQDILEQNGRRIIQEYEIGMALIHCSITEFCNPTHKFISDSLPTTESVTSSMAFNSSIIVPNTERHSAQSNATPISELVVPESIECEMEQDASKPHSEDQASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAILLDSSLEEDVTPAPAPAPVQRVTRQSKAIAEEKSVHPPVPAASKHITRKTKQVFCVDSSDEENENARKPKETPAPTIPSMAKKKTEAPVATRISPRLNGKSLATNITNQPADKHAVPAKRPVLSVASSDEEDEGDLFQFRKSPQKPAETVVQPRIAGKGNAPARISVVDFLEKSQAQEPAPVPPQLESQSQTQPRKRLRLELLNESDSDDCDNLFNFADSKKKRKTQEAQRNDDSTDGLFNFNSERPSDHDDEDSRLTEPFVPETESKKQSKYIVAPRRDRPKKVDISGWLSCSRLNDNIKSEIDADSVKMETSIKADPDEEQWLAAMKDSIEVRMCNLNIVIRSQEEVDASLEDSVNKHGGRKNFKKFVKTKNPHPQKRIVALKSLRLADGMVTCV
Protein: Protein transport protein sec23-2 (O94672)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C4.03c
- Protein transport protein sec31
- Protein transport protein sec24
- Protein transport protein sec13
- Protein transport protein sec22
- COPII coat assembly protein sec16
- Protein transport protein sec23-1
- Small COPII coat GTPase sar1
- Probable UDP-N-acetylglucosamine pyrophosphorylase
- Large ribosomal subunit protein uL11A
Sequence:
MNFEDIEDQDGIRLSWNTFSATPAENARAVIPIAAMYTPLHENERMTIEQYDPVACRAPCRAVLNPYCHVDLRARFWICPFCFQRNPLPAQYSDISSNSLPLELLSQSTTMEYVLSKPVKSPPVFLFVMDTAVDESELTALKDAVIVSLSLLPPDAIVGLITYGSLIQVHEIGFEAMPKSYVFQPAADYSTMKLQQLLALSGNQIRSSSSKAKISGTGITLNLGAASRFLMPVQKCEMHLLNILEQLQPDCLEVPAGQRQLRCTGAAVKIASDLLGIAFPKCGSRIELFCGGPCTVGLGQVVSTELKEPMRSHSEIANDKAKHFKKSKKFYSSLAERLSNQGHALDLFAGCLDQVGIMEMENLVNNTGGAIVLSDSFTTSIFKQSFQRLFSVDASGYLKMGFMANLEVLTSKGLTICGMIGNGVGENKKGTNISDTQIGISKTNSWKMAAISPKSSYALYFDLGKEMGNPNSQRPTQAFIQFLTYYQHSSGTYRLRVTTISRSFITGNAKSISESFDQEAAAAIVARMALFKCQTEDEMSVTRWIDRNLIRLCQHFADYRKEDPSSFRLLPNFTLYPQFIFHLRRSPFLHIFNNSPDETSFYRHMLNVADVNDSLIMIQPTLQSYSFNEPEGVPVLLDSVSIKPDVILLLDTYFHILIFHGSTIAQWRNAGYQEQPEYVNLKELLLAPRLEVTELLADRFPIPRFIVCDQGGSQARFLLSRINPSVSFNKSSQFSPMSKDSETVLTDDVNLQKFMDHLRKMAVIS
Protein: MADS-box transcription factor 15 (FDRMADS3) (OsMADS15) (Protein APETALA1-like A) (RMADS215) (Q6Q9I2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- MADS-box transcription factor 1
Sequence:
MGRGKVQLKRIENKINRQVTFSKRRNGLLKKAHEISVLCDAEVAAIVFSPKGKLYEYATDSRMDKILERYERYSYAEKALISAESESEGNWCHEYRKLKAKIETIQKCHKHLMGEDLESLNLKELQQLEQQLESSLKHIISRKSHLMLESISELQKKERSLQEENKALQKELVERQKNVRGQQQVGQWDQTQVQAQAQAQPQAQTSSSSSSMLRDQQALLPPQNICYPPVMMGERNDAAAAAAVAAQGQVQLRIGGLPPWMLSHLNA
Protein: Olfactory receptor 2C3 (Olfactory receptor 2C4) (Olfactory receptor 2C5) (Olfactory receptor OR1-30) (Q8N628)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MMEIANVSSPEVFVLLGFSTRPSLETVLFIVVLSFYMVSILGNGIIILVSHTDVHLHTPMYFFLANLPFLDMSFTTSIVPQLLANLWGPQKTISYGGCVVQFYISHWLGATECVLLATMSYDRYAAICRPLHYTVIMHPQLCLGLALASWLGGLTTSMVGSTLTMLLPLCGNNCIDHFFCEMPLIMQLACVDTSLNEMEMYLASFVFVVLPLGLILVSYGHIARAVLKIRSAEGRRKAFNTCSSHVAVVSLFYGSIIFMYLQPAKSTSHEQGKFIALFYTVVTPALNPLIYTLRNTEVKSALRHMVLENCCGSAGKLAQI
Protein: Sushi domain-containing protein 4 (E7FEC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFHHADKGGKKSAFGHPVCGQIILSIILLRPPLLVTAFPVNTVEEQICKDPGFPEHGIRTPSIGKFFENSVARFSCADGFSLKGPAKIICTRFYNGSLGWKPSLKPVCLSEDCLPPFIEDADVTNRTYRPGDSLIISCHEGFQIRYPDTETMESVCQADGTWDNQPTCQGCLRPLIPPHSYMNISETKFSVPVGTVVHYQCFPGYKLEGPELLECMYNLIWSDTPPRCLDVEACSLPPMIEHGDYTCHPHPCDRYIHGTVVEYYCYPGYSLANDYKYITCQYGQWFPQMQLYCVKDETTWPGFQDSLLTTWKVVACTATSVLLALLLVITAKMFHYKCKSQQSPSDEPDESRDPNILVVDGVAVPLPSYEEAISGNYCQPPNDLPPDGLESAQHSEEQNPPSYPGHTGSQNSVPLDTGDVENCDSLSDTSECLQGLQPSSSHPGGLNMSEKTNAITSMEETASTSPSIDIADEIPLVEDGEEDC
Protein: DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) (Q13472)
Organism: Homo sapiens (Human)
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:29290614}.
Interaction partners:
- RecQ-mediated genome instability protein 1
- RecQ-mediated genome instability protein 2
- RecQ-like DNA helicase BLM
- Fanconi anemia group M protein
- Replication protein A 32 kDa subunit
- Replication protein A 14 kDa subunit
- Fanconi anemia group G protein
- Fanconi anemia group A protein
- Replication protein A 70 kDa DNA-binding subunit
- DNA replication ATP-dependent helicase/nuclease DNA2
Sequence:
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
Protein: Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3) (P15172)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor E2-alpha
- Histone acetyltransferase p300
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
- Transcription factor 12
- Transcription factor 4
- Histone acetyltransferase KAT2B
- Myocyte-specific enhancer factor 2A
- TATA-box-binding protein
- Myoregulin
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
Sequence:
MELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPEEHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAAFYAPGPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSPDAAPQCPAGANPNPIYQVL
Protein: Spore membrane assembly protein 1 (Q02651)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane.
Interaction partners:
Sequence:
MACTNDGPNKYPEIVSVKHLFQHSGSKHEFSAGKRFSKSIGKIFKRNSALKTSRTETANHKMELKKREGVTLLPPVPESLLHKLNSWLETFSSTKNMKIEENKIVINEKEIRDSVSYYPDKNGGSAVFCYLPDLVLYYKPPIKVTGKQCPIKRSPWESMEIQYQKFMYPLERLERQFEEVPFRPWYFAMRLKELYRCCERSFTNAANRGKARLLRGKQRTKKSYHKTVNLVSAKISTHSNAPSPG
Protein: Eukaryotic translation initiation factor 4B3 (AtTif4B3) (eIF4B3) (Q9SZP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes the eIF4F and eIF4A RNA-dependent ATP-hydrolysis activity with different efficiency depending on mRNAs, thus providing mRNA discrimination during initiation of translation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- N-lysine methyltransferase
- Large ribosomal subunit protein uL5m
- Probable mediator of RNA polymerase II transcription subunit 19b
- Large ribosomal subunit protein P3y
- Large ribosomal subunit protein P3z
- Plant intracellular Ras-group-related LRR protein 9
- AR781
- At1g31300/T19E23_12
- Protein LATERAL ROOT PRIMORDIUM 1
- VQ motif-containing protein 4
Sequence:
MAAAVSSVWAKPGAWALEAEEHEAELKQQPSPTNQKSSAEDSSDFPSLAAAATTKTKKKKGQTISLAEFATYGTAKAKPAPQTERLTQAELVALPTGPRERSAEELDRSKLGGGFRSYGGGRYGDESSSSRWGSSRVSEDGERRGGGFNRDREPSRDSGPSRADEDDNWAAAKKPISGNGFERRERGSGGGFFESQSQSKADEVDSWVSTKPSEPRRFVSSNGGGGDRFEKRGSFESLSRNRDSQYGGGGGSESDTWGRRREESGAANGSPPPSGGSRPRLVLQPRTLPVAVVEVVKPESPVLVIVEKPKGANPFGNARPREEVLAEKGQDWKEIDEKLEAEKLKDIAAAMEKPNEKSTGKMGFGLGNGRKDEERIERSWRKSTEHSEEDAQEEEPAVEGAKKEETEDKPAVEEAKKEETEGEQAVEEAKKEETGGEPAVEEAKKEETEDKI
Protein: Small glutamine-rich tetratricopeptide repeat-containing protein 2 (SGT/UBP) (Viral protein U-binding protein) (Q12118)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Golgi to ER traffic protein 4
- Ubiquitin-like protein MDY2
- Heat shock protein 104
- UPF0303 protein YBR137W
- ATPase GET3
- Mitochondrial protein import protein MAS5
- ATP-dependent molecular chaperone HSC82
- Golgi to ER traffic protein 1
- Heat shock protein SSA1
- Golgi to ER traffic protein 2
Sequence:
MSASKEEIAALIVNYFSSIVEKKEISEDGADSLNVAMDCISEAFGFEREAVSGILGKSEFKGQHLADILNSASRVPESNKKDDAENVEINIPEDDAETKAKAEDLKMQGNKAMANKDYELAINKYTEAIKVLPTNAIYYANRAAAHSSLKEYDQAVKDAESAISIDPSYFRGYSRLGFAKYAQGKPEEALEAYKKVLDIEGDNATEAMKRDYESAKKKVEQSLNLEKTVPEQSRDADVDASQGASAGGLPDLGSLLGGGLGGLMNNPQLMQAAQKMMSNPGAMQNIQKMMQDPSIRQMAEGFASGGGTPNLSDLMNNPALRNMAGNLFGGAGAQSTDETPDNENKQ
Protein: Uncharacterized protein (Q586N7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- KU70 protein
Sequence:
MLRSLLLRGAAVLRGLPSVKKKELKGMVKAKKAAKLNAKGSSEPVVKTKEKTKPKAEQRVTAADKQRKQREREAERLFLQMVREERKRRRLVIRAAIRKAVSKEKEEESKLVRHYAANKRKAIAELQRLKQEDVAASVSPAPPRKTTRGRRAAKAADAEAERAFKKKIESEAEQKFLLLIEELSKKRREELQNAAALLKKQKEAESAPPVMAVANEAPLAAPEAAEAVEALAAEEMATTKTKRRRRVKSETQPEVVAAVVEEGNEEEIIHAPVIEAKGRRNRSPRKEGPKTVVAPAVIAPVVEGEDLLPVVVATAAEEEPVIKDVTVEAVDDVQEVAPVEKSEVKKTPRQRRSSPKAVKLPSVAAPVTPVVDHTPPLVAYAEVPATQQQQQQQQQQQLSHAFSLAGFADAPLVPLTGPTTPFVQRGLTGVPSFDIPVVPLRANPVETLVHNTRGVVPAPPAQFTLNIPAAQPATTPQRITNTGLLRL
Protein: Macrophage metalloelastase (MME) (EC 3.4.24.65) (Matrix metalloproteinase-12) (MMP-12) (Q63341)
Organism: Rattus norvegicus (Rat)
Function: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 2
- Metalloproteinase inhibitor 3
- Matrilysin
- Elastase, neutrophil expressed
- Metalloproteinase inhibitor 4
Sequence:
MKFLLVLVLLVSLQVSACGAAPMNESEFAEWYLSRFFDYQGDRIPMTKTKTNRNLLEEKLQEMQQFFGLEVTGQLDTSTLKIMHTSRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKRADVDYIFQKAFQVWSDVTPLRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLRHSNNPKSIMYPTYRYLHPNTFRLSADDIHSIQSLYGAPVKNPSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFFFKDWFFWWRLPGSPATNITSISSMWPTIPSGIQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHYPRSIHSLGFPASVKKIDAAVFDPLRQKVYFFVDKQYWRYDVRQELMDAAYPKLISTHFPGIRPKIDAVLYFKRHYYIFQGAYQLEYDPLLDRVTKTLSSTSWFGC
Protein: DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) (B0S581)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLAGFFEEKQARYCIRFLDVFQPEDSASSVSGGLFSILKKFEIPASNMVAVYINDHELTSESVVSQIRELNPQVIDLGGLYSIPDTACSAGLQTHSVQVQELIANIYRHFSTGSTSNDNLKMLFAGIDGLKVHSNPLSNSEEFCVLVKRIHEMWSDLVSYFSSCDENNDNVKQICSQLENPKIRLTLMFLDQALGPLRAFGQHLQQSKSSVRADLVEILREASGLLRSYASSFLRPQAVIRYLKEQDPAILDNEAFCLPAAELSLGGVLEDFISAREEELADFLSTFYNECLAIYKTLTTSIAASLPLSDSVLRAISQLLSPAGRLKVTGKNIVDLAVRFGFCSKPEDSAKLNDEFLEYQLAEEENLSSTHSIERYWCTVLKTFPPTSVFKRLVLCLLVLPSPSLDATKIFAQAIENGDADQLDDSSSESDTDMTKELDSNDDNSLDNSELQISPIKNGIMKKSRRSTSEVNLKNDGAKNDGTLTSNTLKEVKNDLSNSTPSPRRGKRDQAYNDGKGFAVGELVWGKVKDFSLWPGLVVPWKGRIVPVSMRRVEWFGDGMFSEIHTDGLLPFGAFSKNFCSKSYEGLPTYKNAIYQILELAAERSGKLFPPSEKKGEEVKAMMDWAFGGFQPMGADGFLPSADSSASNKTESDSSVSDYQPPAKRKYVFKNRPSTQECNRDQMVQEVTSKGRKIEDFCLSCGSSNTEIFHPLFKGSLCIKCKENFTETLYRYDDDGYQSYCTVCCAGLEVILCGNASCCRCFCKDCLNVLVGPGTFDKLKEVDPWSCYVCLPSKCYGVLKLRTDWSVRVQEFFANNSAFEFEPHRVYPSIPAHKRRPIRVLSLFDGIATGYLVLKDLGFKLERYIASEICEDSIAVGMVKHEGKIEYVKDVRTITRKHLAEWGPFDLLIGGSPCNDLSMVNPARKGLFEGTGRLFFEYYRMLTMMRPKEDDDRPFFWLFENVVAMSAHDKADICRFLECNPVMIDAVKVSPAHRARYFWGNLPGMNRPVATSLTDNVDLQDCLESGRTAMFSKVRTITTKSNSIKQGKTGPLPVTMNGKEDYLWCTEMEKIFGFPKHYTDVNNMGRGQRQKVLGRSWSVPVIRHLFAPLKDYFACE
Protein: Urocortin-3 (Stresscopin) (Urocortin III) (Ucn III) (Q969E3)
Organism: Homo sapiens (Human)
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Subcellular location: Secreted.
Interaction partners:
- Corticotropin-releasing factor receptor 2
- Corticotropin-releasing factor receptor 1
- Urocortin-2
- Corticoliberin
- Urocortin
- Corticotropin-releasing factor-binding protein
Sequence:
MLMPVHFLLLLLLLLGGPRTGLPHKFYKAKPIFSCLNTALSEAEKGQWEDASLLSKRSFHYLRSRDASSGEEEEGKEKKTFPISGARGGARGTRYRYVSQAQPRGKPRQDTAKSPHRTKFTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQIGRKK
Protein: Acetolactate synthase (EC 2.2.1.6) (C8V916)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- ACT domain-containing protein
- Ketol-acid reductoisomerase, mitochondrial
- Threonine dehydratase
- L-serine ammonia-lyase
- L-serine ammonia-lyase
- 3-isopropylmalate dehydrogenase
- 3-isopropylmalate dehydrogenase
- Pyridoxal-phosphate dependent enzyme, putative
- 2-isopropylmalate synthase
- Malic enzyme
Sequence:
MMPLRPSKSALRTLHYQRYIASGRRAFASAVSTPHRFSTQKRDQSTATATASTSRPRPSPAFNQEPSRNEVSPLQNRQLPELDDSFVGLSGGEIFHEMMLRLGVKHVFGYPGGAILPVFDAIYNSKHFDFILPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDAFSDGTPMVVFCGQVVTTSIGTDSFQEADVVGISRACTKWNVMVKSVAELPRRIQEAFEIATSGRPGPVLVDLPKDITAGILRKPIPMQSTLPSRPSAATLAAKELSEKQLHSTINRVARLVNVAKKPVLYVGQGILENPDGPKLLKELADKACIPVTTTLQGLGGFDELDPKSLHMLGMHGSAYANLAMQEADLIIALGARFDDRVTGSIAKFAPQAKLAASENRGGIVHFEIMPKNINKVVQANEAVEGDCAENIRHLLPLVEPVSERPEWFAQINDWKTRFPLSLYEKQTPDGPIKPQALIEKLSDLTAHMKDRTIITTGVGQHQMWAAQHFRWRRPRSMITSGGLGTMGYGLPAAIGAKVARPDCLVIDIDGDASFNMTLTELTTAAQFNIGIKVLLLNNEEQGMVTQWQNLFYEDRYSHTHQKNPDFVRLAEAMGVAAERCTKPSEVESKLKWLIESDGPALLEVFTDRKVPVLPMVPGGSGLHEFLVFDEAKDRERRALMKKRNPNGV
Protein: Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2) (Q92819)
Organism: Homo sapiens (Human)
Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:22887999, ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:30394292, ECO:0000269|PubMed:8798477}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Vesicle {ECO:0000269|PubMed:30394292}. Golgi apparatus membrane {ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Lysosome {ECO:0000269|PubMed:30394292}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles (PubMed:30394292). Post-translational modifications control HAS2 trafficking (PubMed:30394292). {ECO:0000269|PubMed:30394292}.
Interaction partners:
- UDP-glucose 6-dehydrogenase
- Hyaluronidase-1
- CD44 antigen
- Hyaluronidase-2
- Tumor necrosis factor-inducible gene 6 protein
- Hyaluronidase PH-20
- Aggrecan core protein
- Hyaluronan mediated motility receptor
Sequence:
MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
Protein: Cystathionine beta-synthase cbs-1 (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) (G5EFH8)
Organism: Caenorhabditis elegans
Function: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. Plays a role in maintaining homocysteine homeostasis. Involved in cold-induced somatic longevity mediated by prostaglandin E2 (PGE2) signals from adult germ cells, perhaps acting via a role in the production of hydrogen sulfide (H2S). Required for normal development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22240119}.
Interaction partners:
- Putative cystathionine gamma-lyase 2
- cystathionine gamma-lyase
- Probable methionine synthase
- Adenosylhomocysteinase
- Serine hydroxymethyltransferase
- L-serine deaminase
- Serine racemase
- Putative cystathionine beta-synthase cbs-2
- Phosphoserine phosphatase
- Hcy-binding domain-containing protein
Sequence:
MIQNEVSATHGSTKKGITYNTILEAAQRPTPLVPLKKLKVEHQLQSDIYVKLEYLNIAGSLEDRTADKAFQFAEEIGVVRGDEVFVTAGGSAAISYATVAAVKGIKLTIYAPKGEFDLVDTVLHTLGVKTVELPFGTFAEARVQTDEAAQQKGVFSLNKFTTNAAFVANLQKTALEIEKAVNNKSIGKVGAVVIPLNTGAAAAGIAAYYKGIGEHGVRVVGVTCKKDTIPEMGLDLKNDLLQEYNVEKREVEEDEAYSFTRHLIGTEGIMAGPSSGAAVLEAIKLAKELPAGSTIVVVLMDGIRNYLRHFLDDDWITANKKDVVTRKDGPQPNSIYDPKVLVYDPTKLAGEWTQDPETKSWSHSEVEFNKFNPERPLVLDTVLDAIGKTPLVKLQHIPKAHGVKCNVYVKCEYMNAGGSTKDRIAKRMVEIAEKTGKPGKLVPGVTLIEPTSGNTGIGLSLASAVRGYKCIITMPKKMSKEKSIAMASLGSTIIRTPNEAGFDSPHSHIGVALRLKSEIQDAVVLDQYCNPGNPLAHYEETAEEIIYDMGDKHIDLVVLTAGTGGTVTGISRKIHERIPTAKVVGVDPHGSILAGPAETDIDFYEVEGIGYDFLPGTLDTSAIDYWAKSHDKESFLMARELIRSEGILCGGSSGCAVHYALEECKSLNLPAEANVVVLLPDGIRNYITKFLDDDWMNERHFLDA