wanglab/gogpt-training-data huggingface dataset:
Protein: Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) (Q9NZ43)
Organism: Homo sapiens (Human)
Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15029241}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15029241}.
Interaction partners:
- Syntaxin-18
- Vesicle-trafficking protein SEC22b
- Vesicle transport protein SEC20
- RAD50-interacting protein 1
- Centromere/kinetochore protein zw10 homolog
- NBAS subunit of NRZ tethering complex
- Alpha-soluble NSF attachment protein
- Syntaxin-5
- Synaptobrevin homolog YKT6
- Syntaxin-7
Sequence:
MAASRLELNLVRLLSRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKVHASKPASEVINEYSWKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSAEPEMDVRKRTGVAGSQPVSEKQLAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTESERLEQHTQKSVNWLLWAMLIIVCFIFISMILFIRIMPKLK
Protein: beta-N-acetylhexosaminidase (EC 3.2.1.52) (Q9W3C4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Alpha-galactosidase
- Alpha-galactosidase
- Glycoprotein 3-alpha-L-fucosyltransferase A
- Hexosaminidase D
- Beta galactosidase, isoform A
- Probable beta-hexosaminidase fdl
- beta-N-acetylhexosaminidase
- Beta-galactosidase
- N-acetyl-D-glucosamine kinase
- SD03412p
Sequence:
MRFSGYNRYQCFCSAVGSLLLLSLLSFAVGAALTRADDVGSDADAGSASRKWLCSRTDICTAEGEMVAGLQYAPEIFESQRDCRLSCGKYGAIWPMPTGKECTISHRRVRFDPWKVRFHVVAPGEAATQFLRETNRLFVSNLLKECIRNCTLETSKQILVRSTVANESLVLDWPTDESYALVVRTTETATFVDIQATTVYGARHAFETLSNLVTGSLSNGLLMVTTANITDRPAFSHRGVLLDTARNFVPLKFIRSTLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAYSSSQTYSRQDALNLVKYARLRGIRILIEIDGPSHAGNGWQWGPAAGLGNMSVCLNQSPWRRFCVQPPCGQLNPLNDHMYAVLKEIFEDVAEVGAPEETLHMGGDEVFLPCWNNTDEIRDGMRARGYDLSEQSFLRLWSQFHQRNLNAWDEINERMYPGIKEPKSVIIWSSHLTNPRYIETYLPKERFIIQTWVESQDALNRELLQRGYRLIVSTKNAWYLDHGFWGSTSYYNWRTVYSSGMPVGRSKDQVLGGEVCMWSEYVDQNSLESRIWPRAGAAAERMWSNPKSSALLAQRRFYRYRERLLARGIHADAVIPHWCVLHEGQCL
Protein: Put3p (Q5AAV6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- UDENN FLCN/SMCR8-type domain-containing protein
- Multifunctional fusion protein
- Proline dehydrogenase
- Multifunctional tryptophan biosynthesis protein
- Formate/nitrite transporter
- Major facilitator superfamily
Sequence:
MDSQEPSEEKKIANALINSDTIPLDLQPPSSPSVSSPMTSTRSNLETSSPLNTNTSLNPRQKRASLACIRCRTRHIRCPGGDPCRKCQLAKSKCEYVEADKKIVVSMKYLSKLHDEIARLKKDNAGLRNNLKEQELKRVDAQQGRPQFANTTPANRVSPLSMASNVMGSQNFSQPHSQTPQTIPSSLTQTPLANGEVIHPSLDKYGRLIQSRTGEKVYVGSSSMTLFGLEIQNMVPSFVSSSLLSNTSSSTTPAPSPSSSDQTLPPPPTQQQQSHQLPNNSSPKQEHYQGKRESKILEKEGNAYKITLSKTKTRPGLSINFELPSYSYAMLLVDTFINYNDGCFYFFNEGLIKRFLMNLYSGKAVENKRILRRNTLQTKSPDQDENTIKKDTDDETILETIWFCKILLIFAIGEMYLGTESSTHARRQKLENMKRSKEKREKHALPGSAFFYQASELFTGLFASGAIDNITKDGGIEVMLLYAFYLQVADCTIASYFYFGLALRAALILGWHVDADKENLNRFELEHRRRIWWTVYMYERMLSSKAGLPLSFADDSVSTELPIDFKIDLTDFPRDEHDVRGYYIFPPADYINNCVTITQINAVILSSLYTKQPSFNILPVVTDLVQRLMAWKTSLPKYLDVDYSVDNPKVSRLVTNLMTEYFQGINLAVRPLLFHFATKKLKELQMQNTQNKYIDLTKYSKNVLTLLNASFQASINTIKSIWSLLQDNMVALFGWMDREYLFTSASTLILFNASFGVHEATRDHLDHALILFTKMKRLGNYPAALRRAQLLKLINVLDFNGVMAELLEKHDDDNNNNNNNTSSRSSSNNSKTLPGSAITNTSDNNVEPFLNPPPIRPGDLDFLQFTNVQGNEGTDGMDGVSNANVGVVGIGDVYANQDLTGIEGLTYLDAEQKLWSDITNEAGWLNMHSAEKDTNITERDPLDEGFIFNTASPDVGTSVHSGYSNLINHEFQDFMDQS
Protein: 2-pyrone-4,6-dicarboxylate hydrolase (PDC hydrolase) (EC 3.1.1.57) (2-pyrone-4,6-dicarboxylate lactonase) (O87170)
Organism: Sphingobium sp. (strain NBRC 103272 / SYK-6)
Function: Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate.
Interaction partners:
- 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
- Protocatechuate 4,5-dioxygenase beta chain
- Gallate dioxygenase
- Protocatechuate 4,5-dioxygenase alpha chain
- Protocatechuate 4,5-dioxygenase alpha chain
- 4-oxalomesaconate tautomerase
- Protocatechuate 4,5-dioxygenase beta chain
- Protocatechuate 4,5-dioxygenase beta chain
- Protocatechuate 4,5-dioxygenase alpha chain
- 3-O-methylgallate 3,4-dioxygenase
Sequence:
MTNDERILSWNETPSKPRYTPPPGAIDAHCHVFGPMAQFPFSPKAKYLPRDAGPDMLFALRDHLGFARNVIVQASCHGTDNAATLDAIARAQGKARGIAVVDPAIDEAELAALHEGGMRGIRFNFLKRLVDDAPKDKFLEVAGRLPAGWHVVIYFEADILEELRPFMDAIPVPIVIDHMGRPDVRQGPDGADMKAFRRLLDSREDIWFKATCPDRLDPAGPPWDDFARSVAPLVADYADRVIWGTDWPHPNMQDAIPDDGLVVDMIPRIAPTPELQHKMLVTNPMRLYWSEEM
Protein: Serine/threonine-protein kinase ATG1a (EC 2.7.11.-) (Autophagy-related protein 1a) (AtAPG1a) (Q94C95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine protein kinase involved in autophagy in a nutritional condition-dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status.
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21984698, ECO:0000269|PubMed:24563201}.
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34
- Autophagy-related protein 101
- Autophagy-related protein 11
- Autophagy-related protein 13b
- Beclin-1-like protein
- Autophagy-related protein 9
- Autophagy-related protein 13a
- Serine/threonine-protein kinase VPS15
- Autophagy-related protein 2
- Autophagy-related protein 3
Sequence:
MESARLVGDYALGPRIGSGSFAVVWLAKHRSSGLEVAVKEIDKKLLSPKVRDNLLKEISILSTIDHPNIIRFYEAIETGDRIFLVLEYCSGGDLAGYINRHGKVPEAVAKHFMRQLALGLQVLQEKHFIHRDLKPQNLLLSSKEVTPLLKIGDFGFARSLTPESMAETFCGSPLYMAPEIIRNQKYDAKADLWSAGAILFQLVTGKPPFDGNNHIQLFHNIVRDTELKFPEDTRNEIHPDCVDLCRSLLRRNPIERLTFREFFNHMFLREPRQIPDVEHSGFSTCTGKSLLPSAQPSTSTNRFKSSAENVHKHGSSSSASNSQISMPHTSFEKTRKDTEGQCSSNQSGVVDSLELIEREYVLVNRPSASLEGSSDCFDTSLQDSGFPNILPRNEKVSSSSLEAQKPLSDVSGPRPASVSYLLTEVQRLTIVHPPTKLQLLHQYAQALTELASEMGNTGQVKESFAVTLVVLAVWRKALEICDSWMMSVGENEVNPDPTTAPETSIPDLNSPAPAKTWVTQEFVTALNQAENLSTQLNETSAATHMPDAMETIYERALAYGKSGGAEEYLSNKESAATLYKKAILLLSFIIEEAVTLSLNPSFSLTPDDKKRILYYISNLQHRRSHL
Protein: p44-2 outer membrane protein (Q2GIT6)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MMSMAIVMAGNDVRAHDDVSALETGGAGYFYVGLDYSPAFSKIRDFSIRESNGETKAVYPYLKDGKSVKLESHKFDWNTPDPRIGFKDNMLVAMEGSVGYGIGGARVELEIGYERFKTKGIRDSGSKEDEADTVYLLAKELAYDVVTGQTDKLTAALAKTSGKDIVQFANAVKISSSAIDGKVCTGSHADLAPGTNAGKKFVVNPEASGSTDGDTSQCSGLGHSSGVTQNPKLFSTFVDTVKIAEDKNWPTGRAKSNTSLKTGDTNSNAKAVATDLVQELTPEEKTIVAGLLAKTIEGGEVVEIRAVSSTFIRIRDKLISLLPLLTWEWKIVHSVCAAGVRYSNLRLLVLLSGTWFIPG
Protein: Leukocyte immune-type receptor 2 (Q5EG08)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
MELRPLRVMILLISLIRVGQAQEFKPVLSVEPNSPQIFRGATVTLTCRISGGNRWYYWSKDGGYSHTSSENFYTIKVDQSHKYRCYGSIDKRQTTLSNEVTLSVIEAVLTLQPDGQIFSGQEVTFTCEIRGHADTEWMYNWYEDGVKISVYTKSRQYSFTPVESLSTKYTCSGQRRSDSQTSETSNTVTLTVSEKPKPELTSSREGAVLKGTSVTLSCTLKPQSAGWKFYWIKPTQSTETETEAETDYYTKTYSSVSVSDEGQYRCRAGRGNPVYYTHYSDALWVNVTDVKAPLSVLKLLSSAVAASPYVLVTIILAVKCYRARTDPDEDNRPYRVIEAEASV
Protein: Protection of telomeres protein 1 (O13988)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.
Subcellular location: Nucleus. Chromosome, telomere.
Interaction partners:
- Protection of telomeres protein tpz1
- Telomerase reverse transcriptase
- Coiled-coil quantitatively-enriched protein 1
- Protection of telomeres protein poz1
- DNA-binding protein rap1
- Protein ten1
- Protein stn1
- Telomere length regulator taz1
- UPF0648 protein C3H5.09c
- ATP-dependent DNA helicase hus2/rqh1
Sequence:
MGEDVIDSLQLNELLNAGEYKIGELTFQSIRSSQELQKKNTIVNLFGIVKDFTPSRQSLHGTKDWVTTVYLWDPTCDTSSIGLQIHLFSKQGNDLPVIKQVGQPLLLHQITLRSYRDRTQGLSKDQFRYALWPDFSSNSKDTLCPQPMPRLMKTGDKEEQFALLLNKIWDEQTNKHKNGELLSTSSARQNQTGLSYPSVSFSLLSQITPHQRCSFYAQVIKTWYSDKNFTLYVTDYTENELFFPMSPYTSSSRWRGPFGRFSIRCILWDEHDFYCRNYIKEGDYVVMKNVRTKIDHLGYLECILHGDSAKRYNMSIEKVDSEEPELNEIKSRKRLYVQNCQNGIEAVIEKLSQSQQSENPFIAHELKQTSVNEITAHVINEPASLKLTTISTILHAPLQNLLKPRKHRLRVQVVDFWPKSLTQFAVLSQPPSSYVWMFALLVRDVSNVTLPVIFFDSDAAELINSSKIQPCNLADHPQMTLQLKERLFLIWGNLEERIQHHISKGESPTLAAEDVETPWFDIYVKEYIPVIGNTKDHQSLTFLQKRWRGFGTKIV
Protein: N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1 (O14357)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Meiotically up-regulated gene 84 protein
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit gpi15
- Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit
- Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- DNA mismatch repair protein msh2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MSTTTMNIASAPIEVKRIYWPKSTISYTDSGYLVGWKYSTNDLIVVTTITSYQSFANFLVDYCKNQDQSVDIKSLCILGTFNCSADILPGDKYEIDCWIKVQQSTELSHPRVFDSASTPLKINLHIIYYHPPQPRKMQFLSLEPLSLLLLKDSFINKSNPEYESMQHQQILLKKLKLHFPRRKENSWKRSLRSGLIELLNQSFEVRMLTHENNNKKNSYVFRLFDRVSSSTFYFFNSLFAYFIILLRIINEVILLAINYRPIPLSYNMMDIFVSARQVDLRLQQACFWPVQYMKLWVFRKSKRVAIEDYKEYIRFYNNLWLVANDMIFGITMSSFILENLHLVVKLIENITFEYAIKNVRSMVIWLVDTPAGLKLNNDICKFIMKLSVWVIDVWSNFLLHCLPWTPFLVQVVAISGFGGASLMIALISDFLSVMTIHIHLLYLASSRLYNWQLRVIYSLLQLFRGKKRNVLRNRIDSYEYDLDQLLLGTILFTVLIFFLPTIYVFYAAFALTRVSVMTCLAICETMLAFLNHFPLFVTMLRIKDPYRIPSGLNFEIVSFEPLKQDGFATLYLNCNSKPMSLGSMFEHYRKLARRLISHYLSKTTLISLLVGCPVPAIPAEQLYNIQYAMLPTKRISIRKLRDLLFHQKKFPYD
Protein: Probable GTP-binding protein OBGC1, chloroplastic (Q0D3S3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable GTP-binding protein that plays a crucial role in chloroplast development and is required for leaf greening during plant growth.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Large ribosomal subunit protein bL27c
- AGR_C_5039p, putative, expressed
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL20c
- 50S ribosomal protein L20
- Os02g0259600 protein
- Large ribosomal subunit protein bL21m
- Delta-1-pyrroline-5-carboxylate synthase 2
- Delta-1-pyrroline-5-carboxylate synthase 1
- Large ribosomal subunit protein bL9c
Sequence:
MAPAVAVVAAAAAFPFRLFSAEARRNTKGSRSKRGSARPLKPSPPPRPSASSSAAGGGGATTFTRLPLRNAPASVEVTLDRFPTANPEPRASTFTRRNGERLGDDEEDEEEEEDEVELGLRGATTFARLPLRDSPDGGDLTIGHFDAGVAPQEGLRSRAISRQLVEHLDDVEEEEEEQVVSRLDIFEGAKGREARAFLPDEDDEDDDVVVFDPEYDGYSDDEEFVATAVEQSPRGDAIAVAELEKLKYDNDDDDDDDDEVVVFHPDDDEEVDVFEDYDDDEEEETKEKGVPAVMRCFDTAKIYAKAGDGGNGVVAFRREKYVPLGGPSGGDGGRGGNVFVEVDGDMNSLLPFRKSVHFRAGRGAHGQGRQQAGAKGDDVVVKVPPGTVVRSAAGDVELLELMRPGQRALLLPGGRGGRGNAAFKSGTNKAPRIAEKGEKGPEMWIDLELKLVADVGIVGAPNAGKSTLLTAISAAKPTIANYPFTTLLPNLGVVSLDFDATMVVADLPGLLEGAHRGYGLGHEFLRHSERCSVLVHVVDGSGEQPEYEFEAVRLELELFSPSLVDKPYIVVYNKMDLPEASERWNKFQEKLQAEGIEPYCISAMNRQGTEDVVLAAYKVLQKDRQRMKDDEEWNGPENLNHVADAIKRERRAPMNEFEIFHDKGTNTWNVVGAGIERFVQMTNWQYSESLKRFQHALEACGVNKTLIKRGVKEGDTVVVGEMEMVWTDEPSKTRSSKTMNSKDDSVRWPEFG
Protein: Protein kinase domain-containing protein (Q23677)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- G-protein coupled receptors family 1 profile domain-containing protein
Sequence:
MTGSVIFFALFSSYCFASCYARNLTLGRNFEDSFKRVPRASEKNELGDSNVQQIIFISLYSVFVALAIGICCLIKAYKSKKRQLPANRSKGNEYLLEPTTADQKKRYSNNIVPPEPTPYPITSGEDDFGKTPSRLSNEECPPELKLAPINDRIKYLHYYAEVEINEEDLDISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGEKRMIISELVENGDLLSFLRKNRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFEKELKTTSNEYFLDLTRKLRSETNNQLRLSNWLSDEKHCDS
Protein: Ras-related protein Rab-1A (P34139)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rab GDP dissociation inhibitor
Sequence:
MNPDYHYLFKLLLIGDSGVGKSCLLLRFADDTYSESFISTIGVDFKIRTIELNGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDKLTFENVRQWLQEIDRFACENVNKLLVGNKSDLVAKKVVDFNTAKAFADSLQIPFLETSAKQSTNVEQAFMTMATEIKNRLTASQPTQTVDKNKVVPGSSAPISPKSGCC
Protein: Iron-dependent extradiol dioxygenase (EC 1.13.11.25) (Q9KWQ5)
Organism: Rhodococcus jostii (strain RHA1)
Function: Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA). Also involved in biphenyl and polychlorinated biphenyls (PCBs) degradation.
Interaction partners:
Sequence:
MSIRSLAYMRIEATDMSAWREYGLKVLGMVEGKGSDPDALYLRMDDFPARLVIFPGEHDRLSVSGWETANAAELQEVRDNLSAAGVAFKEGTAEQLQDRRVDELITFEDPSGNTLEAFHGAALEHRRVVSPYGHKFVTGEQGLGHVVLSTTDDEASLRFYRDVLGFRLRDSMRLPPQLVGRPADGKPAWLRFFGCNPRHHSLAFLPMPTPSGIVHLMIEVENSDDVGLCLDRALRKKVKMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVEDESWIARESTAVSLWGHDFSVGMQP
Protein: L-ascorbate peroxidase 5, peroxisomal (AtAPx04) (EC 1.11.1.11) (Q7XZP5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a key role in hydrogen peroxide removal.
Subcellular location: Peroxisome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- L-galactono-1,4-lactone dehydrogenase, mitochondrial
- Monodehydroascorbate reductase 3
- Glutathione S-transferase DHAR3, chloroplastic
- Monodehydroascorbate reductase 2
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase DHAR2
- At1g05270
- Monodehydroascorbate reductase 4, peroxisomal
- Monodehydroascorbate reductase, chloroplastic/mitochondrial
Sequence:
MAVNVDAEYLKEIEKTRRDLRALISSRNCAPIMLRLAWHDAGTYDAKKKTGGANGSIRFKEELNRPHNKGLEKAVAFCEEVKAKHPRVSYADLYQLAGVVAVEVTGGPAIPFTPGRKDADSADDGELPNPNEGASHLRTLFSRMGLLDRDIVALSGGHTLGRAHKERSDFEGPWTQDPLKFDNSYFVELLKGETPGLLQLKTDKALLDDPKFHPFVKLYAKDEDMFFKAYAISHKKLSELGFNPPRRIPSAVTQQTLGIAVAAAVVIFTICYEASRRGK
Protein: HCLS1-associated protein X-1 (HS1-associating protein X-1) (F1RGL0)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MSLFDLFRGFFGFSRPRSHRDPFFGGMTRDEDEDDEEEEATWSQGSSRFEGPQPPEEFGFGFSFSPGGGMRFHDNFGFDDLVRDFNSIFSEMGAWTLPSRPPASTCHLSAELPGPEIETPGERRQEGQTLRDSMLKYPDSHQPRIFGGGLESDAKTESPKPVPDWDSQRPFHRFDDMWPVTPSSRAREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGTVEERRTVVDSEGRKETTVTHQEAGDSPRDGPESATPPSLDDAFSILDLFLGRWFRPR
Protein: Epithelial sodium channel subunit beta (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (P37090)
Organism: Rattus norvegicus (Rat)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:11352848, ECO:0000269|PubMed:11773057, ECO:0000269|PubMed:9118951}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11352848, ECO:0000269|PubMed:11773057}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}.
Interaction partners:
- Epithelial sodium channel subunit gamma
- Epithelial sodium channel subunit alpha
- NEDD4-like E3 ubiquitin protein ligase.
- E3 ubiquitin-protein ligase NEDD4
- Prostasin
- Serine/threonine-protein kinase Sgk1
- Solute carrier family 12 member 1-chloride cotransporter 1)
Sequence:
MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPNAEVYPDQQTLPIPGTPPPNYDSLRLQPLDTMESDSEVEAI
Protein: Gp3 (Q9FZR9)
Organism: Mycobacterium phage Ms6
Interaction partners:
Sequence:
MRIDGQYVGLGPGDRSDEIRKIKAFMRRKFSYAATLADTEFYDEAMTAVVAEMQSRYNTAGQLRDGLYIPGIINAETKYVMGYLSRPVIDTRPVLFTVCGTGVPWWVGPDADTARAVEDQYLWQPIGYPAAPFPMGRSITAGITEAHNQANRWRERIETHGTALAGYSQGAVVLSELWMNHIAPEDGSLRWMKPHVRKAVTWGNPNRELGHVWADHGGSPMAPSNTQGVSSNGMRNTPDWWRDYAHQGDLYACTEPGDTQEVRNAIWQIVRDLDLFTGPDSLLAQVIELAQAPLPETIAITRAILDAGMFFAKRTGPHVDYNPQPAIDYLRT
Protein: Uncharacterized protein (Q387Z2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEGAARTVPAQFARLPPTEHALLLNRFKFLNLVQRIAAADVAEMIDTVGLEALTFKGTLEKLSLEGFPASGVSRSPHIMGTDTVHGFGSHMKDEIHGKGHLTGRVRGKGARERRFSSPKEEKEFINRLARPRNYRNQFGTDWRRYPQGTPTSEPAHVPGDPSAQSVWHRKKSDVSADLYDNRLRVSNDEDDLYGDNVVIESSDDRLQQHDGGAHNATWKSFRQPDQEGFRDDAIHGGERCNIGESAGGFADAPPSNTVEGISTLGAQKRENINAPSILSKGAWTKNQPGAPGGQFVAFDAASAHTMNSARRNRASFAPKAKPKAAPDVQRVPMEVIRQASLLLADKQVAEPLQQPPPPQIPPSGAQNPTQSNTLSAYGSNFRGSGSQVQVPSSGSLNSKKEVDSSCIVPKRVSDDTLAELTLCVEKMLQDHRKVLEGILKDERPAPDDPPAVVRRSEQGGRGGVADGGINMTREKTSVKERKPSPKSTHGVSGSTMGRINDLLEDISDEEDELLLVNRIQRKIGAMDRDIEAIEARGKQVHGSLGENDGDHEGIYDRETSSKNTNRRVAFADTISSSRRRGRRRGEMPRAIVERIRSFQKENHEYIQYTERLWNTSKVTEQVFAYRLTESLLDDALCEVISEVGGILDTYVEGLTHHELQ
Protein: Cyclin-T2 (CycT2) (O60583)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1. Involved in early embryo development (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TQK0}. Nucleus {ECO:0000250|UniProtKB:Q7TQK0}. Note=Nucleus in differentiating cells. {ECO:0000250|UniProtKB:Q7TQK0}.
Interaction partners:
- AF4/FMR2 family member 4
- Cyclin-dependent kinase 9
- Protein HEXIM1
- AF4/FMR2 family member 1
- RNA polymerase II elongation factor ELL3
- Protein ENL
- RNA polymerase II elongation factor ELL2
- Cyclin-T1
- Bromodomain-containing protein 4
- Protein AF-9
Sequence:
MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSARTEQLYSQKQETSLSGSQYNINFQQGPSISLHSGLHHRPDKISDHSSVKQEYTHKAGSSKHHGPISTTPGIIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKQGQSQAASSSSVTSPIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLRSPVGLSSDGISSSSSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM
Protein: Uncharacterized RING finger protein P8B7.23 (O94271)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
Sequence:
MLNGEKSALGEMPSNSNSSSKLNAKSPNFIPSSSNIPRSSAKTKEHSADRKPHRNSEKKTQGMPRKNQQLASSERKTKNKKRLEKQSSAIADSIGESLDDPQTVYDEHLFDILSARTNKRGQINLNHLLNFQFTPRTNSNAFSAPPRRSRGYNTYGQGSGHHPMDKSRYVNANYRFVVSPIGDYQSQKLDPDSPVKWEDVWQVLCSSDFQLAACPFCLEEKPVAARMSRCGHVYCFSCLLRFVETPTAAEVKAAETSGTKIVKCGHRSCPICWDSIRLRDVHPIRWVEDKEFQKLEEGKSVCLRLYQRNNGSILAFPRSCRSFALDGSFHSDEIPNFTMSGAAYARIIIGSHDYMVQQHLLEIEQLQQIAAEDISLYGSADTYYERITQILLDRISSLSESVNEQNIKSLQTDIDNLCLQSNSLKQLSEVDDLNDVSGSEIADAYLFYQPFAHSHIYLSPLDIRILKSAFGSYENFPDELVPRVERISSGHLVNSELRQRFKYMAHLPEGCEVAFIECDWSKIIPKEVLLTFKSEISKRRKQRKAQEMREERYRQRAERDTEEQIYSELNMQRPVPKTVVHEDPAEAFPTLGSHHQFESTDEVNTDESTLSTAKTVWGTRALANIQNDTDDQDDLDGWKVDWDKVAQLSAPSKNSKNKKKKKLVLLSTGAAHR
Protein: Alpha-defensin 2 (Cryptdin-1) (Defensin-related cryptdin-2) (P28309)
Organism: Mus musculus (Mouse)
Function: Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MKPLVLLSALVLLSFQVQADPIQNTDEETKTEEQSGEEDQAVSVSFGDREGASLQEESLRDLVCYCRTRGCKRRERMNGTCRKGHLMYTLCCR