wanglab/gogpt-training-data huggingface dataset:
Protein: Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase) (Q54JD9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Probable acetyl-CoA acetyltransferase
- hydroxymethylglutaryl-CoA lyase
- 3-hydroxybutyryl-CoA dehydrogenase
- acetyl-CoA C-acyltransferase
- Hydroxymethylglutaryl-CoA synthase B
- Hydroxymethylglutaryl-CoA synthase A
- 3-oxoacyl-[acyl-carrier-protein] reductase
- Acetyl-CoA C-acyltransferase
- Phosphoenolpyruvate carboxykinase, mitochondrial
- Adenylosuccinate lyase
Sequence:
MLSRNLKTLVKNKNILYFTTSTSKSNKIYENAKEAVKDIPNGSKLLVGGFGLCGIPENLISAVRDTGVKDLTVVSNNAGVDDFGLGVLLKSRQIKRMISSYVGENATFESQYLKGELEVELTPQGNLAERLRAGGAGIPAFYTSTGVGTVLVEEGGFPIKYANDGSGKVEIKSEPRPTQLYNGRKYCLEESITGDYALIKAWKADTRGNLVFRNTARNFNPPMATAAKITIAEVEEIVDAGEIKPDEVHVPGIYIQRIVKGPSFEKRIERLTVQKEKTGEAAAKPKDEAAAKRERIVRRAALEFEDGMYCNLGIGMPTLASNFIPKGIRIELQSENGLLGMGPFPKMGEHDADLINAGKETVTTIPGSSIFSSADSFAMIRGGHVDLTILGGMQVSGNGDLANWVIPGSMVKGPGGAMDLTSSGSRVVVIMEHTTKHGKPKILKNCTLPLTGKSCVNRIITELAVFDVVNGKLELIEVVDGQTVDDIKSKTEAEFTVSKNLKPLQQVEI
Protein: DNA polymerase eta (Q7T2X8)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRGRERVVALVDMDCFFMQVEQRFDPRLRGRPCAVVQYNQWQGGGIIAVSYEARAFGVSRGMWATEARALCPELLLARVPEARGKADLTRYREASAEVMEVLSRFAAIERASIDEAYLDLTGSARERLRELRGRPLEAELLPTTFVQGLPAEPGLQPADKEELRRRGLQEWLASLSFDNVNCPDLQLAMGAVIVEEIRVAVEKATGFRCSAGISHNKMLAKLACGLNKPNRQTLVSSRSVPQLFSQMPVSSIRNLGGKLGVAITDILGVEYIGEVTKFSEMELQTHFGDKTGSWLYDLCRGIDDEPVKNRHLPQSIGCSKNFPGKTALATQKEVQHWLLQLALELESRLIKDRSQNHRVAKQLMVVIRMQGDTRLSRFCAVTRYDAQKIFNDAFALIQNCNMAGAHQAAWSPPLISVHLAASKFSAPTFLSAGIASFLTSDTSSDGTDAGSTEATSSTRPRVKFFRSPSKEHRQKPANAIESFFQKVAERQQSQAVPSGLPAATHAHSPAASSMEHPEGDSAGLASEQRELEASVKQSPRDGSPASPCKRPPCEELLSDATQTPSTPPSSRILPKLKPALEGNEQNLPPPEQALLPHVSPGDQQCCEKCGQYVLAWELPEHMDYHFAVELQRSFQEPSSPPALAEVPIAKAAASGSPAKVGNKGPRASSRES
Protein: Rifin (O96295)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFALPLNILIYNQRNHKSTTHHTLKIPITRLLCECELYAPTNYDSDPEMKRVMQQFVDRTTQRFHEYDNRMKDKRQKCKDKCDKEIQKIILKDKLEKELMDKFATLQTDIQNDAIPTCVCEKSLADKVEKVCFRCGGLLGGGIAPGWGLVSGLGYVGWTNYVTQTALQKGIEAVISYLEQIPGIKGLPGFNLANIVNPNNYSSGGLLTTAIDAAARPICSVNHSKTPAFCSYATQNGGSIIAKVSVDAENAANAGIDAASAEAANLAPKTLTLTNTIIVSFVAIVVIVLVMLIIYFILHYRRKKKMKKKLQYIKLLKE
Protein: Mitochondrial import inner membrane translocase subunit Tim13 (Q9Y5L4)
Organism: Homo sapiens (Human)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim8 B
- Mitochondrial import inner membrane translocase subunit Tim8 A
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial import inner membrane translocase subunit Tim23
- Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
- Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
- Mitochondrial intermembrane space import and assembly protein 40
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import inner membrane translocase subunit Tim10 B
Sequence:
MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM
Protein: E3 ubiquitin-protein ligase TRIM8b (Similar to tripartite motif-containing 8) (Tripartite motif containing protein 8) (Tripartite motif-containing 8b) (B7ZVP9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- RING-type E3 ubiquitin transferase
Sequence:
MAENWKNCLEEELICPICLNVFSEPVQLPCKHNFCRMCINEAWSKDAGMVRCPECNNAYTQKPALEKNHKLSNIVEKFNALNVEKTPAVLHCILCRRGPPLQAQKVCLRCNAPCCHSHVQTHLQQPSSNAGHLLVDAEDVRAWSCPQHDEYRLYHCETEHVAVCQYCCFSRCATNHGHAVCDIEVRRNDIRQMLIKQQDRIEDRVQDIEEQLYKLESDKCLMEDKVQHLKEEVQLQYQKMQQLLEEDLGKTLEVLDKAHSKFCQENSAQALQLHQKQQEAKKLLSSIQMVFDKAEDIGFMKNTKSVKILMDRSQSYVGSTLSPYKVGSLNSKLFLSEISKREKNLCKMLEAPFSAPANFFQSIPAYLCEKRRHSMAFPEGSGSSRAGASYMDSSSSSGPASAKQPCLSLTQGSAPGEGQSSQQALGPCGSGQHVGSSSSASGSQPLPHSTSVFPHSHYPNGSSSQLPQYGARKILMCTVDNCYCSGVPSVSNHRGHPPYPRSSSFPWPVSSQEYSHAPLPSAPAMSQSLQSLSMRDWIDASQSHRHTDFYSLYGQSSTKHYVTS
Protein: Transmembrane protein (Q38FH7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSLPGVARYERMTTRNKIQFFWWSMLVMGFAYQFLQMTVLRVQPKREEQMYSHIRELYGDQLPPELIEIAKRQREAQDALTLSNMIRTPTPGETAGALQHALDPRRIAQLRSHNGY
Protein: TIR domain-containing protein (Q9N5Z3)
Organism: Caenorhabditis elegans
Interaction partners:
- Pelle-like serine/threonine-protein kinase pik-1
- Protein kinase domain-containing protein
- Death domain-containing protein
- TNF Receptor Associated Factor
- Peptidase M14 carboxypeptidase A domain-containing protein
- NAD
- Mitogen-activated protein kinase pmk-1
- Antibacterial factor-related peptide 2
- Neuropeptide-Like Protein
- Protein dbl-1
Sequence:
MRRKMKLFLFLLLVINICRSAAANGDECPKFCKCAPDPVQPTSKLLLCDYSSKNTTITPIASSNYDQVANIRSLFISCDNNNFQFPDAYFKSLTALHHLRIVGCETTHFSVKLFEDLAALRRLELDQISTASTSFEMTEDVLMPLARLEKFSLTRSRNIELPQRLLCSLPHLQVLNISSNELPSLRREESCVAQQLLIVDLSRNRLTNIEQFLRGIPAIRQISVAYNSIAELDLSLATPFLQQLDAEANRIVDLTSLPGTVVHVNLAGNALKRVPDAVAELASLVALNVSRNEIEAGNSSVFSSPELEMLDASYNKLDSLPVEWLQKCEKRIAHLHLEHNSIEQLTGGVLANATNLQTLDLSSNQLRVFRDEVLPENSKIGNLRLSNNSLELLEPSSLSGLKLESLDLSHNKLTEVPAAIGKVEQLKKVDLSHNRIAKVYQYVLNKIKQLHTVDLSNNQLQSIGPYIFSDSSELHSLDVSNNEISLLFKDAFARCPKLRKISMKMNKIKSLDEGLTEASGLRRLDVSHNEILVLKWSALPENLEILNADNNDINLLTAASMSPSTANLKSVSLSNNGITIMNADQIPNSLESLDVSNNRLAKLGKTALAAKSQLRRLNLKGNLLTVVATESMKVVEAVHPLKVEISENPLICDCQMGWMIGGAKPKVLIQDSETASCSHAVDGHQIQIQSLSKKDLLCPYKSVCEPECICCQYGNCDCKSVCPANCRCFRDDQFNINIVRCHGNSSMVPKREFVVSELPVSATEIILSGVTLPQLRTHSFIGRLRLQRLHINGTGLRSIQPKAFHTLPALKTLDLSDNSLISLSGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPNLKYLTLHNNSLEDIPQVLHSTALSKISLSSNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWFSLHRHLVVDFPKVECWENVTKAFLTNDTTVLSAYPPNMGNDVFVMPIEEFLRDYNSTICVPFSSGFFGQDPQNSILFVIITISIAVLLCVLVILAISFIRKSHDAINQRRYKASSLNCSTSAGSSPLPVPLLSYHAFVSYSKKDEKMVIDQLCRPLEDEDYQLCLLHRDGPTYCSNLHAISDELIAQMDSSQCLILVLTKHFLENEWKTLQIKTSHQLFAKNRAKRVIAVLGDGVDANLLDDELGQILRKHTRIEMRSHLFWTLLHSSLPSRLPLPSNSGDDSSQLYSDIYGIVPSDVV
Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (A0A8I6AEH7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAHRLRFHFGSGRSNTAPESEILDQEREEDFFMAFQTLPRRSSPHPFTQNAGEDSGLQEGVGALKRSSSMFIPQLLAGVDARPTRSSSMKISLQRKAADGATDSCGPQEGPDDRPPSAQGDLGDQAAATRVSAQIGSSEPSPVDTPGSSPPRAAWDPGTLVNGTCDHRGPSPRLAEDTEEATPGLRIQHRASSADVRQVRLLPFGPDGQAEPRRWSLQHVPDASGSSGKRCFVFQLQQPHQGTVGLGSDFNFGFTGTKGDRLVRYPRIRLERSTSYPTQPRAGRVSPTEDRGTPEASPRRMVPEIRRTNSERTPQSPGCMFKIRQDQNAGQQHFRILVTRGPEEAPQNQEETPKSPGHPGTGVPTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLPPEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: TBCC domain-containing protein 1 (Q9NVR7)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20168327}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20168327}. Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia.
Interaction partners:
- Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
- Protein SHQ1 homolog
Sequence:
MDQSRVLLWVKAEPFIVGALQVPPPSKFSLHYLRKISTYVQIRATEGAYPRLYWSTWRHIACGKLQLAKDLAWLYFEIFDSLSMKTPEERLEWSEVLSNCMSEEEVEKQRNQLSVDTLQFLLFLYIQQLNKVSLRTSLIGEEWPSPRNKSQSPDLTEKSNCHNKNWNDYSHQAFVYDHLSDLLELLLDPKQLTASFHSTHSSLVSREAVVALSFLIEGTISRARKIYPLHELALWQPLHADSGFSKISKTFSFYKLETWLRSCLTGNPFGTSACLKSGKKLAWAHQVEGTTKRAKIACNTHVAPRMHRLVVMSQVYKQTLAKSSDTLAGAHVKIHRCNESFIYLLSPLRSVTIEKCRNSIFVLGPVGTTLHLHSCDNVKVIAVCHRLSISSTTGCIFHVLTPTRPLILSGNQTVTFAPFHTHYPMLEDHMARTGLATVPNYWDNPMVVCRENSDTRVFQLLPPCEFYVFIIPFEMEGDTTEIPGGLPSVYQKALGQREQKIQIWQKTVKEAHLTKDQRKQFQVLVENKFYEWLINTGHRQQLDSLVPPAAGSKQAAG
Protein: RING-type domain-containing protein (Q583R3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVTVEGAHVECLICASPCEALVLFQCGHYVCYICGLHIHSLDNGGCPMCRECGPVLVTRDIPGGLNPGQDKVSAEVIRQLTDESIVDSVLQCKVHGRVLAQELKKLYEFVCPVPKCWRRGEQEPFCEQHHLHAHLKYDHEVSYCPICLQHRSVFLAEQMVYSPEALCLHMVGEYEHDPASFLGHPPCRFCKGMHMYDEDHLLKHMRERHFTCDICNRGEFRFTYYENRGKLLMHFKQAHKICDHKQCSELDPMMRVFASDLDLAVHKQRVHGIRSRLTMSPGAGPDSVPVNPAVPATGTNANAVHIIFDHINRQETLTLVPSREEESKNQRRSFGGSGKNKKGRKIFVDIAPHNVTGLPQHFRSKNILAPILYRGTEGTSSDEQRETSVSGQVTQLLTRAFGVTESEETYNNKNNVPLNPEEQKRKLTDAIQEELKDQRRITQLHCCTADFIDGKMLTTEYYNQLRTQFFITDESFKAVFPLLVATMPVTDKRDALIHVDKMRNAPEMRQARRAREEMKKEETEEEQVNKQKNIGRNNQQWPNRPGNKNNNNNRNKKGPPNVWMERAKRAEADAQNNRSLAASSAAALVSGVGNASNNNNNNNNNNNNDTSITSSSQEVVSLIAGSTWGAARQQRGGAPGRQATEAPARPSSGGAFINAEDFPALPTVATRRVPPSVRTKRSNQLNAWHLPIVEKCGAVSIAFPFFSFFPLFTIVHMLSNYGYFGKELLWFAEGSKTVLLFICLWSSFYALSVNCLLLSA
Protein: Retrotransposon hot spot (RHS) protein, putative (Q584N0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWNSIRRFYTDGLHAARRFLKRLRGDEEGPTWTMNSSIEDVLLQRFAGLRDMKLHDLLNHHFGETLGTSNVSVGVFVQSPEDYIVNAKFLGRIQRLDEFQLLRAVIYLPRNRIEDIHQWEENATAQIREFVGPVAATKLDSALRIAKEARKRAHQTADGVELKGVYESIYNATWGYVESGHNDLPLGMKVVGNSDGEPELWTEEEVNVSHTPYDLCDPLPRHGNLEIAVLTSQMGWPYNRFRTPRRAIQEGEEKPKVHVFDRDVYIRREVMRVWYLVKQRLDLWLGPELVEEPFPCVLVGTPGIGKSFGVGSFLLQRLLHYDSERLRNIAYFVKGEAYIFFRATNDHPRKVVFYEKEVDGLDAVKALVEEEGLGYIIYDFWKDRHQPIPADLPGAWPVIVLTSPDPNNYKDWKEPRGCEFLCINCYEEVELKAAVAWRRLSKLEESKITEAHIINLENEWQKTLGWIKKVGPLARQVLEGEKRYKGRVREINEALAEISRGDDSHYMKVLNSRVQWRQDGTTYMLAKLVRVVTENGEECRNRAVSIDIEQKLRVWANTACMRDNYLRKVFRGKEERAADEFENVGVYAFTMGNVVQTIVTHLRYLPRVGEEMDSNVSVLASGNAVGRVPTSLRQFNPETTGQDIEVGCFYRPVQGNFPVVDAFFFVTEPAVDREGRAIITTTIVLLQATVAPTHHTTREKVDKFIKAMKQLFGEWDELARNLKWELIYIQYSDSKPIEERQKCEPVGGRGDHTTELWNKINQFQVKMEGNIVKEITQDEPNAIAGGPAA
Protein: Pentatricopeptide repeat-containing protein At3g63370, chloroplastic (Protein ORGANELLE TRANSCRIPT PROCESSING 86) (Q9M1V3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA editing event in chloroplasts. Required for the editing of a single site in rps14 transcript.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19934379}.
Interaction partners:
- Phosphoglycerate mutase family protein
- Multiple organellar RNA editing factor 9, chloroplastic
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS14m
Sequence:
MEYAVTNMRLLSNMMYSASAISFPRVRLHCSIPTEPSCRRNPFRQSNQPVQVPSPKLACFDGVLTEAFQRLDVSENNSPVEAFAYVLELCGKRRAVSQGRQLHSRIFKTFPSFELDFLAGKLVFMYGKCGSLDDAEKVFDEMPDRTAFAWNTMIGAYVSNGEPASALALYWNMRVEGVPLGLSSFPALLKACAKLRDIRSGSELHSLLVKLGYHSTGFIVNALVSMYAKNDDLSAARRLFDGFQEKGDAVLWNSILSSYSTSGKSLETLELFREMHMTGPAPNSYTIVSALTACDGFSYAKLGKEIHASVLKSSTHSSELYVCNALIAMYTRCGKMPQAERILRQMNNADVVTWNSLIKGYVQNLMYKEALEFFSDMIAAGHKSDEVSMTSIIAASGRLSNLLAGMELHAYVIKHGWDSNLQVGNTLIDMYSKCNLTCYMGRAFLRMHDKDLISWTTVIAGYAQNDCHVEALELFRDVAKKRMEIDEMILGSILRASSVLKSMLIVKEIHCHILRKGLLDTVIQNELVDVYGKCRNMGYATRVFESIKGKDVVSWTSMISSSALNGNESEAVELFRRMVETGLSADSVALLCILSAAASLSALNKGREIHCYLLRKGFCLEGSIAVAVVDMYACCGDLQSAKAVFDRIERKGLLQYTSMINAYGMHGCGKAAVELFDKMRHENVSPDHISFLALLYACSHAGLLDEGRGFLKIMEHEYELEPWPEHYVCLVDMLGRANCVVEAFEFVKMMKTEPTAEVWCALLAACRSHSEKEIGEIAAQRLLELEPKNPGNLVLVSNVFAEQGRWNDVEKVRAKMKASGMEKHPGCSWIEMDGKVHKFTARDKSHPESKEIYEKLSEVTRKLEREVGYVADTKFVLHNVDEGEKVQMLHGHSERIAIAYGLLRTPDRACLRITKNLRVCRDCHTFCKLVSKLFRRDIVMRDANRFHHFESGLCSCGDSW
Protein: Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin-2) (Q8JZZ7)
Organism: Mus musculus (Mouse)
Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Teneurin-2
- Teneurin-4
- Teneurin-3
- Teneurin-1
- Netrin receptor UNC5D
- Netrin receptor UNC5A
- Netrin receptor UNC5C
- UNC5C-like protein
- SUZ RNA-binding domain-containing
- Vascular endothelial growth factor B
Sequence:
MVSSGCRMRSLWFIIIISFSPSTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYSKMLVFVCPGTLKAIVDSPCIYEAEQKSGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETAYDKRAASNAFMICGVLYVVRSVYQDNESEAGKNTIDYIYNTRLSRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTTISTTSSASQRGPVSSTAAGPQDGSRGTKPPPAVSTTKIPPVTNIFPLPERFCEALDWKGIKWPQTQRGMMVERPCPKGTRGTASYLCMASTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGHVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRAEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQVQDFKFPLGLKGLGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADLMGRNSTIAVNSPVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHHLLLTVITWVGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYTIACPVFAGLLHFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTVQACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFALLCLLGLTWSFGLLFVNEETVVMAYLFTAFNAFQGLFIFIFHCALQKKVRKEYGKCFRHWYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPAFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLRKADYHDGVQVVDCGLSLNDTAFEKMIISELVHNNLRGGNKTHNLELKLPVKPVIGGSSSEDDAIVADASSLMHGDNPGLEFRHKELEAPLIPQRTHSLLYQPQKKVKPEATDSYVSQLTAEADDHLQSPNRDSLYTSMPNLRDSPYPESSPDMAEDLSPSRRSENEDIYYKSMPNLGAGRHLHMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL
Protein: HTH-type transcriptional repressor NsrR (Q5E2D6)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Function: Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.
Interaction partners:
- Flavohemoprotein
- Anaerobic nitric oxide reductase transcription regulator NorR
- Cysteine desulfurase IscS
- HCP oxidoreductase, NADH-dependent
- Anaerobic nitric oxide reductase flavorubredoxin
- Alternative oxidase 1
- cytochrome-c oxidase
- DNA-binding response regulator in two-component regulatory system with NarQ
Sequence:
MQLTNFTDFGLRALIYLGSLPEGELTSITVVTETFDVSRNHMVKIINKLGQEGYVKTIRGKNGGICLGKPADQIIIGDVIRAIEPLQVVNCAPEFCHITPACRLKGALAKAKQAFLDELDKHTIQDMLTDNSELLILLKRI
Protein: Ras-related protein Rab-26 (EC 3.6.5.2) (Q504M8)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland.
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:20038531}; Lipid-anchor {ECO:0000305|PubMed:20038531}; Cytoplasmic side {ECO:0000305|PubMed:20038531}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ULW5}; Lipid-anchor {ECO:0000250|UniProtKB:Q9ULW5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9ULW5}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250|UniProtKB:P51156}.
Interaction partners:
- Autophagy-related protein 16-1
Sequence:
MSRKKTPKSKGGSEPATSTLPAAAAATNGPRLAHPRTVRPGPEAPPNGPPQSIRPSLGSTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQAWLTEIQEYAQQDVVLMLLGNKVDSTQDRVVKREDGEKLAKEYGLPFMETSARTGLNVDLAFTAIAKELKQRSAKAPSEPRFRLHDYVKREGRGVSCCRL
Protein: Oxysterol-binding protein homolog 7 (Oxysterol-binding protein-related protein 7) (ORP 7) (OSBP-related protein 7) (P38755)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis. Involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport. Binds phosphatidylserine and PI4P in a mutually exclusive manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16096648}. Cell membrane {ECO:0000269|PubMed:20008566}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20008566, ECO:0000269|PubMed:23934110}. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:20008566, ECO:0000269|PubMed:23934110}.
Interaction partners:
- Oxysterol-binding protein homolog 6
- Vacuolar protein sorting-associated protein 4
- Vesicle-associated membrane protein-associated protein SCS2
- Phosphatidylinositol-3-phosphatase SAC1
- Increased sodium tolerance protein 2
- Vesicle-associated membrane protein-associated protein SCS22
- SEC14 cytosolic factor
- Phosphatidylinositol 4-kinase PIK1
- Oxysterol-binding protein homolog 1
Sequence:
MALNKLKNIPSLTNSSHSSINGIASNAANSKPSGADTDDIDENDESGQSILLNIISQLKPGCDLSRITLPTFILEKKSMLERITNQLQFPDVLLEAHSNKDGLQRFVKVVAWYLAGWHIGPRAVKKPLNPILGEHFTAYWDLPNKQQAFYIAEQTSHHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYTLSQPNVYARGILFGKMRIELGDHMVIMGPKYQVDIEFKTKGFISGTYDAIEGTIKDYDGKEYYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHFPLAPKVRPLEEQGEYESRRLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAEPGEDLDYYIYKHIPEGTDKHEEQIRSILETAPILPGQTFTEKFSIPAYKKHGIQKN
Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (Minichromosome maintenance protein 4) (AtMCM4) (Q0WVF5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA replication licensing factor MCM2
- DNA replication complex GINS protein PSF2
- Probable DNA helicase MCM8
- DNA replication licensing factor MCM3
- Cell division cycle 45
- Origin of replication complex subunit 2
- DNA replication complex GINS protein SLD5
- Minichromosome maintenance 10
- DNA replication licensing factor MCM5
- Cell division control protein 6 homolog
Sequence:
MASDSSLGNTNDGPPSPGENVSSPIENTYSSPAALHRRRRGRSSTPTQFATPPPPPSRLASSNSTPPTSRPSAARSKGRNGHGGGGGGGGGGDPGTPMSTDEPLPSSDDGEEDGGDDTTPTFVWGTNISVQDVKSAIEMFVKHFREARENSDDLFREGKYMVSIRKVIEIEGEWIDVDAFDVFDYDPDLYNKMVRYPLEVLAIFDIVLMDIVSTINRLFEKHVQVRIFNLRTSTSMRNLNPSDIEKMISLKGMIIRSSSIIPEIREAVFRCLVCGYFSDPIIVDRGKISEPPTCLKQECMTKNSMTLVHNRCRFADKQIVRLQETPDEIPEGGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAMTVRVGPAHRTVKSVFKTYIDCLHIKKASKLRMSAEDPMDVDNSLRRVDEDVELDEEKLRKFQELSKQPDIYERLSRSLAPNIWELDDVKKGLLCQLFGGNALNLASGANFRGDINILLVGDPGTSKSQLLQYIHKLSPRGIYTSGRGSSAVGLTAYVAKDPETGETVLESGALVLSDRGICCIDEFDKMSDSARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIENIHLPPTLLSRFDLIYLILDKPDEQTDRRLAKHIVALHFENAESAQEEAIDITTLTTYVSYARKNIHPKLSDEAAEELTRGYVELRKAGKFAGSSKKVITATPRQIESLIRLSEALARMRFSEWVEKHDVDEAFRLLRVAMQQSATDHATGTIDMDLINTGVSASERMRRDTFASSIRDIALEKMQIGGSSMRLSELLEELKKHGGNINTEIHLHDVRKAVATLASEGFLVAEGDRIKRV
Protein: LD43683p (Obstructor-A, isoform A) (Obstructor-A, isoform B) (Q9VR79)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI03450p
- Glutamate synthase
- Vermiform, isoform I
- Knickkopf
- Chitin deacetylase-like 4
- Gasp, isoform A
- Adrenodoxin-like protein 2, mitochondrial
- Adrenodoxin-like protein 1, mitochondrial
- FI21247p1
- GEO12096p1
Sequence:
MKLFLCAIAVTLCVATTVSAANFECPKPNGQFADEVQCDKFYVCDDGVAKAKLCPDGLVFDPLNRKFNKCDQPFNVDCEDRTELQEPKSSKYCPRKNGFFAHPDPAVCNIFYNCIEGDALETKCTVGLHFDEYSGTCVWPDTAKREGCNPEQRTSETGFVCPKDQPKTDDRGQVVTHPKYPHPTDCQKFYVCLNGEDPRDLGCQLGEVYNDATEMCDAPENVPGCEDWYKDVDDKKD
Protein: General transcription and DNA repair factor IIH subunit TFB6 (TFIIH subunit TFB6) (Q08816)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
- General transcription and DNA repair factor IIH subunit TFB4
- Cyclin CCL1
- General transcription and DNA repair factor IIH subunit SSL1
- Serine/threonine-protein kinase KIN28
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- General transcription and DNA repair factor IIH subunit TFB1
Sequence:
MSEPNTPLHAQPNEQLDLNNLNDLDEKDIDDLNLDPNSDVEISADSGDVVNSNIDNVIWQRNCNKKRRYHTPEFNDVYNETNNTINDVTMLDDVDDFQPRINVSSPFSSATKLSELLPNDHNGTSHPRRLSMSQQSKFISYVDDQLLQIQRKFVQSRGLNIKNGYASLTPLLQDLKTLVDFVWYSIAHVPNSDYLLQSEEKRHCPDSRNPKDTCGYSSYFGQGSYLIKIADDLIDYVEKFTFKNMEDSEINDTLSKLFKLFFILDRIFVILTDDNDNCKEVPKTSSASKNIAGLNGTDIVRLKGIAERTRVRLPIFLESQGIHGYHYELSKIYEGFLDHANSF