wanglab/gogpt-training-data huggingface dataset:
Protein: Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) (Q9HD42)
Organism: Homo sapiens (Human)
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
Subcellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
Interaction partners:
- Vacuolar protein sorting-associated protein 4B
- Charged multivesicular body protein 2a
- IST1 homolog
- Vacuolar protein sorting-associated protein 4A
- Vacuolar protein sorting-associated protein VTA1 homolog
- Charged multivesicular body protein 3
- RNF103-CHMP3 readthrough
- Charged multivesicular body protein 2b
- Charged multivesicular body protein 5
- Charged multivesicular body protein 6
Sequence:
MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN
Protein: Glutaredoxin-like protein C5orf63 homolog (Q9CWB7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLWFQGKSLQIAKSSFGLLRNLSASNRALPVLTLFTKAPCPLCDEAKEVLQPYKDRFILQEVDITLPENSTWYERYKFDIPVFHLNGQFLMMHRVNTSKLEKQLRKLEQQVLATN
Protein: Speedy protein A (Protein expressed in male leptotene and zygotene spermatocytes 465) (MLZ-465) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (mSpy/Ringo A) (Speedy-1) (Spy1) (Q5IBH7)
Organism: Mus musculus (Mouse)
Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:20339383}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- SUN domain-containing protein 1
- M-phase inducer phosphatase 3
- Cyclin-dependent kinase inhibitor 1B
- Nuclear transcription factor Y subunit beta
- Nuclear transcription factor Y subunit alpha
- DNA polymerase epsilon subunit 3
- Telomere repeats-binding bouquet formation protein 2
- Telomere repeats-binding bouquet formation protein 1
Sequence:
MRHNQMYCETPPTVTIHVKSGSNRSHQTRKPISLKRPILKDSWEASENNAQNNKSKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVHLPRGPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDTGELMEKDSQELHSAFSVDTAGDPPHTYSQVANDHQSNKENETNFVKKNKSVEWFAESEE
Protein: (+)-delta-cadinene synthase (D-cadinene synthase) (EC 4.2.3.13) (P93665)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.
Interaction partners:
Sequence:
MASQVSQMPSSSPLSSNKDEMRPKADFQPSIWGDFFLNCPDKNIDAETQKRHQQLKEEVRKMIVAPMANSTLKLAFIDSVQGLGVSYHFTKEIEDELENIYHNNNDAENDLYTTSLRFRLLREHGFHVSCDVFNKFKDEQGNFKSSVTSDVRGLLELYQASYLRVHGEDILDEAISFTSNHLSLAVASLDHPLSEEVSHALKQSIRRGLPRVEARHYLSVYQDIESHNKVLLEFAKIDFNMVQLLHRKELSEISRWWKDLDFQRKLPYARDRVVEGYFWISGVYFEPQYSLGRKMLTKVIAMASIVDDTYDSYATYEELIPYTNAIERWDIKCIDELPEYMKPSYKALLDVYEEMEQLVAEHGRQYRVEYAKNAMIRLAQSYLVEARWTLQNYKPSFEEFKANALPTCGYAMLAITSFVGMGDIVTPETFKWAANDPKIIQASTIICRFMDDVTEHKFKHRREDDCSAIECYMEEYGVTAQEAYDVFNKHVESAWKDVNQGFLKPTEMPTEVLNRSLNLARVMDVLYREGDGYTYVGKAAKGGITSLLIEPIAL
Protein: Small ribosomal subunit protein mS33 (28S ribosomal protein S33, mitochondrial) (MRP-S33) (S33mt) (P82926)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein bS21m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS3m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS15m
Sequence:
MSSLSEYALRMSRLSARLFSEVARPTDSKSMKVVKLFSEQPLAKRKETYDWYPNHNTYFALMGILRSVGLYRDEHQDFKDEQLRLKKLRGKVKPRKGEGKRAAKKK
Protein: ABC transporter G family member 1 (ABC transporter ABCG.1) (AtABCG1) (White-brown complex homolog protein 1) (AtWBC1) (O80946)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MARIVAANDDDSMELNTISSIHDSTLGQLLKNVSDVRKMAIGDETPVHESLNQDYNDGYMRTVPFVLSFDNLTYNVSVRPKLDFRNLFPRRRTEDPEIAQTARPKTKTLLNNISGETRDGEIMAVLGASGSGKSTLIDALANRIAKGSLKGTVKLNGETLQSRMLKVISAYVMQDDLLFPMLTVEETLMFAAEFRLPRSLPKSKKKLRVQALIDQLGIRNAAKTIIGDEGHRGISGGERRRVSIGIDIIHDPILLFLDEPTSGLDSTSAFMVVKVLKRIAQSGSIVIMSIHQPSHRVLGLLDRLIFLSRGHTVYSGSPASLPRFFTEFGSPIPENENRTEFALDLIRELEGSAGGTRGLIEFNKKWQEMKKQSNRQPPLTPPSSPYPNLTLKEAIAASISRGKLVSGGESVAHGGATTNTTTLAVPAFANPMWIEIKTLSKRSMLNSRRQPELFGIRIASVVITGFILATVFWRLDNSPKGVQERLGFFAFAMSTMFYTCADALPVFLQERYIFMRETAYNAYRRSSYVLSHAIVSFPSLIFLSVAFAATTYWAVGLDGGLTGLLFYCLIILASFWSGSSFVTFLSGVVPSVMLGYTIVVAILAYFLLFSGFFINRNRIPDYWIWFHYMSLVKYPYEAVLQNEFSDATKCFVRGVQIFDNTPLGELPEVMKLKLLGTVSKSLGVTISSTTCLTTGSDILRQQGVVQLSKWNCLFITVAFGFFFRILFYFTLLLGSKNKRR
Protein: Double-strand-break repair protein rad21 homolog (mHR21) (Pokeweed agglutinin-binding protein 29) (PW29) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)] (Q61550)
Organism: Mus musculus (Mouse)
Function: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).
Subcellular location: [Double-strand-break repair protein rad21 homolog]: Nucleus {ECO:0000269|PubMed:10375619}. Chromosome {ECO:0000269|PubMed:10375619}. Chromosome, centromere {ECO:0000250|UniProtKB:O60216}. Note=Associates with chromatin. Before prophase, scattered along chromosome arms. During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (By similarity). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (By similarity). {ECO:0000250|UniProtKB:O60216, ECO:0000250|UniProtKB:O93310}.; SUBCELLULAR LOCATION: [64-kDa C-terminal product]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O60216}. Nucleus {ECO:0000250|UniProtKB:O60216}.
Interaction partners:
- Structural maintenance of chromosomes protein 3
- Structural maintenance of chromosomes protein 1A
- Cohesin subunit SA-2
- Cohesin subunit SA-1
- Transcriptional repressor CTCF
- Structural maintenance of chromosomes protein 1B
- Cohesin subunit SA-3
- Nipped-B-like protein
- Separin
- Wings apart-like protein homolog
Sequence:
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEPEQSTSNLNEKMNHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNGSLGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFFLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQQQQPQPQRDVIDEPIIEEPSRLQDSVMEASRTTIEESAMPPPPPQGVKRKAGQIDPEPSIPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII
Protein: Gremlin (Q566Z5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR037254}.
Interaction partners:
Sequence:
MSSKVALCLLLAGALCVVSAARKNRPQSSVPSPYKTSSNTSNRRTRKQEVLASSQEALVVTEKKYLKSDWCKTQPLRQTVSQEGCRSRTVINRFCYGQCNSFYIPRHVKKEQESFQSCAFCRPQRFTSLTVELDCSDLQPPVRYRKIQRIKQCRCMSVSVSESGKQ
Protein: Rho type GEF (O62527)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}.
Interaction partners:
Sequence:
MDQPLVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMGIKRQLSNLSNSSLGHLNAAHMSPPSSHILLPAGGRPPATPSSIPAGSSSGGSHSHQGSPATNSMSHHKRSQSFNHHLSYNQYTPTQPPPHHLHPPQPPSLPSHLGASGPRSSSAQTPNSKTAAPLQASSMDASPAIQAAAAAAAAAVGMGVPSARKGSTKANWTISCLRPTPPLRPSLLNATSGSGSGSGGSGGGGSSSSNALASYCSGRKNQPTYEEDALVLRVFEAYCAAYQNNARNTIHSGLENEDMTPTLRQLWTAIRQMQQDMSQIKLQINEERALRADLQQLLMQHLETSSVSSGANTPKC
Protein: POU domain protein (A0A0C4DG88)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
VQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQGLLHGLENFLTKN
Protein: Bardet-Biedl syndrome 1 (Q9VS19)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bardet-Biedl syndrome 9
- BBSome complex member BBS5
- BBSome complex member BBS4 homolog
- Bardet-Biedl syndrome 8
- BBSome interacting protein 1
- No mechanoreceptor potential B, isoform D
- Outer segment 6
- Centrosomal protein Cep290
- Intraflagellar transport 20
- Intraflagellar transport 52
Sequence:
MAGAPNWLHVDTAEEAPPPHLTTLTSCMALSDVQCDGYVRLLAADISLDNAAEEPTATLKVFRGLKLKHEQPLPGIPAAIESLYIDETEPKTPVIAVAIAESVLFYRHLKPYFKYTIPAQDSEDLELEVWRKLPVVKPSAHPALLDSLKTIDHSKLSRKSQRLLQMGEQEREHFIATHKDSPVGRVGNIVAMCCIKRISSDANPPSHLVLATDTGHIMILEPQGFNLVYQGKACDDETAVPSLISVQGTFETDFCIVVATRNGGVYLLRKSQSEGQEIFKLGIPLTGLLLLPIDQTIIASTMDNRYLCYSKRGKLLYQVPMSDLPVCLLPLPLTHLGLTLVAIALRGGVVKFYLQRYLVDEFVLEETVDAMLYGRMGMEDHVLTLVTQSGGIVVKILRRVSRFEPKAGDLANKRALGDNKSIVDASILDKPKKSSIFVEQAAREKQQAKSTYGSFQVELWRLRHTAARATIDAINSSESTISGDLTHAPVKLSAEVCGSGPAFRLYLTVQNLSTFKMASNLVVLLHADRRHYTIPQTLARLPSVLPGVPLRVDFEVVAVLDPMDKLPPASLTPDNSLIRVMLMKAGQAKPLIAAAISMPQSEAAF
Protein: Putative inorganic pyrophosphatase C3A12.02 (EC 3.6.1.1) (Pyrophosphate phosphohydrolase) (PPase) (P87118)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Plasma membrane ATPase 2
- Plasma membrane ATPase 1
- Inorganic pyrophosphatase
- Putative purine nucleoside phosphorylase
- ATP synthase subunit alpha
- ATP synthase subunit 5, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- Probable V-type proton ATPase 20 kDa proteolipid subunit
- V-type proton ATPase subunit D
- Tubulin beta chain
Sequence:
MASLAKNILQFRSKITGKLNTPDFRVYCYKNNKPISFFHDVPLTSDKDTFNMVTEIPRWTQAKCEISLTSPFHPIKQDLKNGKLRYVANSFPYHGFIWNYGALPQTWEDPNVIDSRTKMKGDGDPLDVCEIGGSIGYIGQIKQVKVLGALGLIDQGETDWKILAIDINDPRAKLLNDISDVQNLMPRLLPCTRDWFAIYKIPDGKPKNRFFFDGNYLPKSDALDIIAQCHQHWKVSRDRKQYIKNFHNESVNNVDLINKINSLKEEVSQNVSNYPSFPYFHTIPNL
Protein: Pyridoxal dependent decarboxylase domain containing 1 (H3BU11)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGC
Protein: Protein transport protein Sec23B (SEC23-related protein B) (Q9D662)
Organism: Mus musculus (Mouse)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15437}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436}.
Interaction partners:
- Protein SEC13 homolog
- Protein transport protein Sec31A
- Protein transport protein Sec31B
- Protein transport protein Sec24A
- SEC24 homolog D, COPII coat complex component)
- Small COPII coat GTPase SAR1B
- SEC24 homolog B, COPII coat complex component)
- Small COPII coat GTPase SAR1A
- SEC24 homolog C, COPII coat complex component
- Large ribosomal subunit protein uL11
Sequence:
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAILNPLCQVDYRAKLWACNFCFQRNQFPPAYAGISEVNQPAELMPQFSTIEYMIQRGARSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQEMLGLTKSAMPVQQARPAQPQEQPFVSSRFLQPIHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKTPIRSWHDIEKDNARFMKKATKHYEMLANRTATNGHCIDIYACALDQTGLLEMKCCPNLTGGHMVMGDSFNTSLFKQTFQRIFSKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKICGLDPSSTLGIYFEVVNQHNAPVPQGGRGAIQFVTQYQHSSTQKRIRVTTIARNWADAQSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPILYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGETIAQWRKAGYQDMPEYENFKHLLQAPLDDAQEILQARFPMPRYINTEHGGSQARFLLSKVNPSQTHNNLYAWGQETGAPILTDDVSLQVFMDHLKKLAVSSAS
Protein: Cytochrome b6 (Q57038)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00633}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00633}.
Interaction partners:
- Cytochrome b6-f complex subunit 4
- Cytochrome f
- Cytochrome b6-f complex iron-sulfur subunit 1
- Cytochrome b6-f complex subunit 8
- Cytochrome b6-f complex iron-sulfur subunit 2
- Cytochrome b6/f complex iron-sulfur subunit
- Cytochrome b6-f complex subunit 5
- Cytochrome b6-f complex subunit 7
- NAD
- Cytochrome c oxidase subunit 3
Sequence:
MFSKEVTESKVFQWFNDRLEVQAISDDIASKYVPPHVNIFYCLGGLTLTCFLIQFATGFAMTFYYKPTVTEAFASVQYIMNEVNFGWLIRSIHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVVGVMLAVTTVTFGVTGYSLPWDQVGYWAVKIVSGVPAAIPVVGDQLVTLMRGSESVGQATLTRFYSLHTFVLPWAIAVLLLLHFLMIRKQGISGPL
Protein: D-glycerate 2-kinase (GCK) (EC 2.7.1.165) (Q9X1S1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Involved in the degradation of serine via 3-hydroxypyruvate. Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate.
Interaction partners:
- Hydroxypyruvate reductase
- Enolase
- Pyruvate kinase
- Glucose-6-phosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- L-lactate dehydrogenase
- Pyruvate,orthophosphate dikinase
- Glucokinase
- Hypothetical protein
- Bifunctional PGK/TIM
Sequence:
MFDPESLKKLAIEIVKKSIEAVFPDRAVKETLPKLNLDRVILVAVGKAAWRMAKAAYEVLGKKIRKGVVVTKYGHSEGPIDDFEIYEAGHPVPDENTIKTTRRVLELVDQLNENDTVLFLLSGGGSSLFELPLEGVSLEEIQKLTSALLKSGASIEEINTVRKHLSQVKGGRFAERVFPAKVVALVLSDVLGDRLDVIASGPAWPDSSTSEDALKVLEKYGIETSESVKRAILQETPKHLSNVEIHLIGNVQKVCDEAKSLAKEKGFNAEIITTSLDCEAREAGRFIASIMKEVKFKDRPLKKPAALIFGGETVVHVKGNGIGGRNQELALSAAIALEGIEGVILCSAGTDGTDGPTDAAGGIVDGSTAKTLKAMGEDPYQYLKNNDSYNALKKSGALLITGPTGTNVNDLIIGLIV
Protein: RNA binding motif, single stranded interacting protein (RNA-binding motif, single-stranded-interacting protein 3 isoform 1) (Q08C34)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAPPSPSTNSSSHSAAEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKASGVQAQMAKQQEQDPTNLYISNLPVSMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCDVVIQHFNGKFLKTPPGVPAPTEPLLCKFADGGQKKRQSQSKYPQNGRPWPREGESGMALTYDPTAMQNGFYSSPYSISTNRMIAQTSITPFIAASPVSTYQVQSTSWMPHQQYVMQPTGAVITPTMDHTISMQPANMMGPLTQQMNHLSLGTTGTYMTAAAAPMQGTYIPQYTAVPASAVSVEGVVTDASPQSVPASSQDASGQQQALGVENTSDHAPTYSFQPAK
Protein: Proteasome regulatory non-ATPase subunit 8 (Q388E9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome regulatory ATPase subunit 6
- Ubiquitin carboxyl-terminal hydrolase
- 26S proteasome regulatory subunit 4 homolog
- Proteasome regulatory non-ATP-ase subunit 5
- Proteasome subunit beta
- Proteasome regulatory non-ATP-ase subunit
- Proteasome subunit alpha type
Sequence:
MANDDPKEPQPAVLNPEVDQQDTSVNGDDGDAERDGGKDVPVFTPAGARVEVHPLVLLSLVDHYARVNAKVSQKRRVAGLLLGRHLSHPGGIQVLDINNSFAVPFDEDPQNPDVWFLDTNYAEEMFLMFRRVHPKVRIVGWYSAGPSCAVQPNDMLLHLLIADRFSLNPVYCIVNTDPNNKGVPVLAYTTVHGRDGARSLEFRNIPTHLGAEEAEEIGIEHLLRDLTDSTITTLSAQVQERELSLDHLGRVLQSIEEYLNDVAEGTMPISEDVLSVLQEVISLQPHIYHLKTSTDMVRHANDQAIAMFIAAIGRCVCTLYDVIANRRRIAREIQEVRARRERSLKEKLGNEQHKAKEAATEESRKEGAAKNKNNGGTSEGK
Protein: Mitochondrial outer membrane protein porin 1 (Voltage-dependent anion-selective channel protein 1) (AtVDAC1) (VDAC-1) (Q9SRH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:19326079, ECO:0000269|PubMed:21705391}.
Interaction partners:
- Mitochondrial import receptor subunit TOM40-1
- Probable mitochondrial import receptor subunit TOM40-2
- Mitochondrial import receptor subunit TOM9-1
- Prohibitin-3, mitochondrial
- Kinesin-like protein KIN-14F
- Translocator protein homolog
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Probable mitochondrial-processing peptidase subunit beta, mitochondrial
- Cytochrome c oxidase subunit 2
- Probable transmembrane GTPase FZO-like, chloroplastic
Sequence:
MVKGPGLYTEIGKKARDLLYKDHNSDQKFSITTFSPAGVAITSTGTKKGDLLLGDVAFQSRRKNITTDLKVCTDSTFLITATVDEAAPGLRSIFSFKVPDQNSGKVELQYLHEYAGISTSMGLTQNPTVNFSGVIGSNVLAVGTDVSFDTKSGNFTKINAGLSFTKEDLIASLTVNDKGDLLNASYYHIVNPLFNTAVGAEVSHKLSSKDSTITVGTQHSLDPLTSVKARVNSAGIASALIQHEWKPKSFFTISGEVDTKSIDKSAKVGLALALKP
Protein: Chromatin component KLETT (Q9GNA6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKRNRRAFAGNNKPFVFGGIYNPNATVKPLIQMPLQAANVQEQQSSPVALYPTSASPVAVQSPQDAFLAVQSPGAPAPVQLANSSDQQNNPDADAIASKLPMPVIIKEEPISVNDEPSVDNIEDNTSASTSASGIGGKIPFKKIFQKRKKSSERTRDKKLRQNRQVRKSMLPKNALMALNEVKGVTISDFTIDSNTDGGFTAVVTVNSNQYEGKGTSKMTAKNAACEKAWRDFIIAKMTPKPPRIHQVEMGSEPMDINEDEADAPDDDLPMLNLASFAIYKLFAEWELEGYVLPEMHPSANAAQQAGGDAGTPVPPLPKEPKKPPVRTELPSGWETMHPATILCIMRPGLNYVDYGSSGDKTNGMQHLGIMVDNQEFHANGRSKKIARRNVAVKVCNSLFGTNFTYTDTT
Protein: Paired box protein Pax-8 (P51974)
Organism: Rattus norvegicus (Rat)
Function: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Homeobox protein Nkx-2.1
- Protein kinase C beta type
- Protein kinase C gamma type
- Retinoic acid receptor RXR-alpha
- Retinoic acid receptor RXR-beta
- Mothers against decapentaplegic homolog 3
- Thyrotropin receptor
Sequence:
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDTFGQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPYAIKQETPELSSSSSTPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFSHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYSHTPYASYSEAWRFPNSSLLSSPYYYSSTTRPSAPPTSATAFDHL
Protein: DeSI-like protein sdu1 (EC 3.4.-.-) (Meiotically up-regulated gene 67 protein) (Q8X1T0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- 26S proteasome regulatory subunit rpn10
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 6A
- Probable proteasome subunit alpha type-5
- Probable 26S proteasome regulatory subunit rpn6
- 26S proteasome regulatory subunit rpn12
- Probable proteasome subunit beta type-6
- Probable proteasome subunit beta type-3
- Probable proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-1
Sequence:
MKVYINVYDLMPDSPVNKLAWTLGLGIYHTGLVLEGKEYAFGAHEIPGSTGVFATMPRPPLEGCRWRCSIALPNCTLPKPDVDRILIRLSQEFTGLSYSLLERNCNHFTNAAAIELTGSPIPSFLNRISRIGLAFPTITNALLQHGQKNTSDVDDSSDSSSDVDEETLIVSKSKKAHKDIPKFSAPPPSADLNNLITDSLP