wanglab/gogpt-training-data huggingface dataset:
Protein: S-antigen protein (P04927)
Organism: Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Function: S antigens are soluble heat-stable proteins present in the sera of some infected individuals.
Subcellular location: Parasitophorous vacuole {ECO:0000269|PubMed:2406433}. Note=Localizes to the cell periphery in early schizonts and then to the parasitophorous vacuole in late schizonts (PubMed:2406433). Following schizont rupture, the S-antigen is released in host sera (PubMed:2406433). {ECO:0000269|PubMed:2406433}.
Interaction partners:
Sequence:
MNRILSVTFYLFFIYLYIYETYGKVKNTDKELSDIYGTKYYLRSGFFNSKKCKGHKYEDLQAEGEGENDKEEDSNNEEMNIDEENGLIEGQGESEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGAEGHGKHAPNKENKNKNKESIKNIMNMFI
Protein: Uncharacterized protein At4g13230 (Q8LFD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING-type E3 ubiquitin transferase
- Putative proline-rich receptor-like protein kinase PERK6
- (Z)-gamma-bisabolene synthase 2 (Terpenoid synthase 13) (AtTPS13)
- Terpenoid synthase 22
- Terpenoid synthase 25
- (Z)-gamma-bisabolene synthase 1 (Terpenoid synthase 12) (AtTPS12)
- Calcium-dependent protein kinase 24
- Alpha-barbatene synthase
- Inactive terpenoid synthase 20, chloroplastic
- Vacuolar protein sorting-associated protein 20 homolog 1
Sequence:
MTSFAVVARLITRAPRVRASVPTRLVHGTTSTRKDSVCDKATEAQQKVAKKADEGAQTISDAAGNLKDKAKNTAEEAWDKVKDTTEKIKDTVTGKTEETKESIKATAKTVERSMNTKNLK
Protein: DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (40S ribosomal protein S3) (Q7ZVD9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}.
Interaction partners:
Sequence:
MAVQISKKRKFVSDGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGGVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPSGKIGPKKPLPDHVSIVEPKEEVLSTTPVSEQKGAKPEVPVMPQGTPVPTA
Protein: Follicle stimulating hormone beta (Q800P4)
Organism: Oncorhynchus kisutch (Coho salmon) (Salmo kisutch)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU004069}.
Interaction partners:
Sequence:
THLKTLQLVVMATLWVTPVRAGTDCRYGCRLNNMTITVEREDCHGSITITTCAGLCETTDLNYQSTWLPRSQGVCNFKEWSYEKVYLEGCPSGVDPFFIPVAKSCDCIKCKTDNTDCDRISMATPSCIVNPLEM
Protein: P-type Cu(+) transporter (EC 7.2.2.8) (B7ZLR4)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004166}. Membrane {ECO:0000256|RuleBase:RU362081}.
Interaction partners:
Sequence:
MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI
Protein: Protein PET54 (Petite colonies protein 54) (P10834)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:8389363}; Peripheral membrane protein {ECO:0000269|PubMed:8389363}.
Interaction partners:
- Protein PET122
- Protein PET111
- COX3 mRNA-specific translational activator PET494
- Mitochondrial COX1 translation regulator PET309
- Cytochrome c oxidase subunit 3
- Intron-encoded DNA endonuclease aI5 beta
- Protein MSS18
- Cytochrome c oxidase subunit 1
- Mitochondrial acidic protein MAM33
- Mitochondrial RNA-splicing protein MRS1
Sequence:
MKASSKAIKLVLDHLKSTGRVLGSVESGNSATISEKTASVNKQQQLQEKKPSVLQYRSYNPYLVKEDFLSILPENLYKKRGQFTNELDFQLMKVRDPKYFQFKDQYYLFFNDYNSLTEYIKLTKHSRINKIRVKMTPLAQPLPTLLTKLQRYSKNLYNAFRSSEQYFEGLNEKVDVSGEFTTNQLRSILDSVEEIENKSVLVWNIPTKLRSHDILNYFWFYNIRSSFKIYWDDEMKRNLRFISFENSHDAYRFKRNYHGLLAKELLTLSEKGDAADYSLEMDDSKILIEHLSE
Protein: Homeobox protein prophet of Pit-1 (Pituitary-specific homeodomain factor) (A0A2R8QKN2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MDIEKPQQQFPENYSEVTVSSSADIDVQIHPRKVSQKSESVRDGGARARPYPSPSRRRHRTTFSNEQLEHLELAFRQNHYPDIYYREELARVTKLNEARIQVWFQNRRAKQRKQDRITQKSLAVSMMPVRGPLFSTMCVSSSAMGRQCQCPHSLPHVPQFSPVLPPGGYPPHPSSGSQFSSPSGSLPSQANRQPNDWYNQLRNIGPSPTSVLSLASVPGLESTSHWN
Protein: Nucleoporin 98-96 (Q867M2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
SKYGLGDSDEEDELPTDPKKAKISTLEAQQRANAEKMTLNSLRQAQKISEDAARNLDPKALVAGVASGFRPMDDTAEFLLMDKTQFFQAGGNSDFSMFDPPRQRPTITSPTAVLAQEMVGNEAHKMQLMKSSFFVEDNAPEDEPMETTGRLLRHRKFFNVEPLVWKDGASESSSQYDFEHPSPALPISSSVSEASLMCDAHYEETSSMATGSIVAAVKETKFEMPVTKAFKFVCKPKVAPIKLRATTVPLPRSIAYEMRDNWIADLGFYKGRSFKLSFGPQNSLVLPSTYNNMQNLKEFTGPSLPVSMVFAPRSATDLSPSVMQLVEFNMVKGNEGFRESIIPHLEVQLNDCLSVNVEGSECPCIHPDSGTKLVSKHFSESLKQRNAGLKEDYSVSVWSLLFALWGDHDELVDLEKNSHYMVMCRRNLLSEWLENTLLGKDLLSKKVSTHSYLEHMLDLLSCHRVNEACELAFSYDDANLALVLSQLSSGAVFRLLMEEQLFAWQQSKSDKYIDLERLKMYMLAAGAPMMQSSHGAINLLENKNWLTALALQLWYFTAPTSSITDALNAYNDAFQAEECYAEPPKPSYRDAPTDTKKPVYDLRYHLLQLHSKRMHSLEETLNPITHTADAMDFRLSWLLLQTLRALGYRHCSPLTEARLSVDFASQLENEGLWQWGIFVLLHIKQQTQRERAVQQMLQRNVSVSAKVALYAEERFIVEELGIPMSWVDYAKAVKAGASGKHHLQAKYLLKAKHFATAHDVIFQHIAPDAIINGKMKYLHSLLIQFEDTEGSSIRVPNWANQGQIFLDFIDISAKFKQIRSVTNIADINARWENLKPQLSELCSRISLLPCPTSKHRLCQSEISQSLSCLVHGMCIVCPEMESSTVLKVALERLPLPQEFASKELRIWLEELLDKIQNEPPFSERQQPTMMEI
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial (EC 7.1.1.2) (Q42599)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 8-B
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- NADH dehydrogenase iron-sulfur protein 3
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase subunit 7
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
Sequence:
MASILARRSLNTLRARHLVLSGQALQGSHLSRLQSRGISYGSNKDDEEAEQLSKEISKDWNTVFERSINTLFLTEMVRGLSLTLKYFFDPKVTINYPFEKGPLSPRFRGEHALRRYPTGEERCIACKLCEAVCPAQAITIEAEEREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFATETHEELLYDKEKLLENGDRWETEIAENLRSESLYR
Protein: Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) (Q9GLW0)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11282275}. Cytoplasm {ECO:0000269|PubMed:11282275}. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity). {ECO:0000250}.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Nuclear receptor corepressor 2.
- Estrogen receptor
- Nuclear receptor coactivator.
- Nuclear receptor corepressor 1.
- Protein kinase cAMP-activated catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Uncharacterized protein.
- Phosphoinositide-3-kinase regulatory subunit 1.
- Uncharacterized protein.
Sequence:
MTERTGKDARAPHVAGGAPSPAPAAEPESRRRDGGRLRASQTSDAPRVAAAAAAAAAAASAAPSAPSDRLLFSRRGQGADPGGKAQDAQPRPDVARADPRLEAASGAGADSPGPPRQDRGPLHGAPSTALRPAGPGQGRSSPAWEPRSPRCPSGPEPPEDPRGARSSQGAACPLMSRPEGKAGDGCGTAGAHKGPPRGLSPSRQPLPLCPGAHAWPGAAGKAATQPAALGVEDEGGFAAEGSPGPLLKGKPRPPAGPAAAAGAAPAAPGTAPGGTAPVPKEDSRLPAPKGSLAEQDAPAPGCSPLATTMMDFIHVPILPLGSAFLAARTRQLLEAETYDAGAFAPPRGSPSAPCAPLAAGDFPDCAYPSDAEPKDDAFPLYGDFQPPALKIKEEEEGAEAAARSPRPYLAAGPHSCVFADAPPALPALPPLPPRAPSSRPGEGAPAAAAAAGCSASSASSPGPALECVLYKAEGAPPPQGPFAAAPCRVPGAGACLLPRDGAAAAASAGAAGASPALYQPLGLGALPQLGYQAAVLKEGLPQVYQPYLNYLRPDSDASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRTLDAVALPQPVGIPNESQALSQRISFSPSQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQNQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Protein: Two-component response regulator ARR15 (Q7G8V2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:12354925}.
Interaction partners:
- Histidine kinase 4
- Histidine kinase 2
- Histidine kinase 3
- Histidine-containing phosphotransfer protein 5
- Protein WUSCHEL
- Pseudo histidine-containing phosphotransfer protein 6
- Auxin response factor 5
- Two-component response regulator ARR22
- Two-component response regulator ARR14
- Adenylate isopentenyltransferase 7, mitochondrial
Sequence:
MALRDLSSSLSSSSSPELHVLAVDDSFVDRKVIERLLKISACKVTTVESGTRALQYLGLDGDNGSSGLKDLKVNLIVTDYSMPGLTGYELLKKIKESSALREIPVVIMSSENIQPRIEQCMIEGAEEFLLKPVKLADVKRLKELIMRGGEAEEGKTKKLSPKRILQNDIDSSPSSSSTSSSSSSHDVSSLDDDTPSSKRIKLESRG
Protein: E3 SUMO-protein ligase NSE2 (E3 SUMO-protein transferase NSE2) (Non-structural maintenance of chromosomes element 2 homolog) (Q8I8H8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDFVSDFSDGGKIKKLLEQSVEQSVEHAVNVIHMKIKHQSLNKAMNQVKNSSATIEEFEEVWKERSKAVEQKRINVKNLDEFKNFVKAVESAAGQAGAEVNDQANGTAYDEDLIMEDSGSEVFSFYDPWSKALIKNPMRNKMCGHIYDRDSVMPIIMDRIGIRCPVLGCANLCYIQPDHLVQDANVQQKIQQSMSNAIVDVTASEEDEE
Protein: DNA repair protein SWI5 homolog (HBV DNAPTP1-transactivated protein A) (Protein SAE3 homolog) (Q1ZZU3)
Organism: Homo sapiens (Human)
Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Swi5-dependent recombination DNA repair protein 1 homolog
- Transmembrane protein 208
- DNA repair protein XRCC3
- DNA repair protein RAD51 homolog 4
- DNA repair protein RAD51 homolog 3
- DNA repair protein RAD51 homolog 2
- DNA repair protein XRCC2
- DNA repair protein RAD51 homolog 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- Meiotic nuclear division protein 1 homolog
Sequence:
MQRRGQRDLWRHNKSCARNRCPRPPRERGGAGFPWVRAQLSVRQFTLRVRVPGPVHLRGRSPTPALDPLAPLNPLIRGPRTPGLRRWIQSLALLLPNCSSSRIPTVPRPHSGLWVQSDFPLGFLSRTEPRLTRSCRGAFRSPRPLPKSGQADGTSEESLHLDIQKLKEKRDMLDKEISQFVSEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKELYPEFGLDMND
Protein: Mitogen-activated protein kinase kinae MST7 (MAPKK MST7) (EC 2.7.11.24) (MEK MST7) (G4NEB8)
Organism: Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae)
Function: Mitogen-activated protein kinase kinase; part of the MST11-MST7-PMK1 MAP kinase (MAPK) cascade that is essential for appressorium formation, penetration and invasive growth. The MST11-MST7-PMK1 MAP kinase cascade transduces signals from the cell surface sensors MDB2 and SHO1 that recognize various surface signals such as surface hydrophobicity, cutin monomers, and rice leaf waxes. MST7 acts as the upstream MAPKK that directly phosphorylates MAP kinase PMK1.
Interaction partners:
- Mitogen-activated protein kinase PMK11
- Mitogen-activated protein kinase kinae kinase MST11
- Mitogen-activated protein kinase kinae kinase MCK1
- Mitogen-activated protein kinase MPS1
- Mitogen-activated protein kinase HOG1
- Guanine nucleotide-binding protein subunit beta
- Cell surface sensor SHO1
- DUF1857-domain-containing protein
- Calcium influx-promoting protein ehs1
- mitogen-activated protein kinase kinase
Sequence:
MADPFAPRTMKRRNVKGLALTPAAPKPPPTAENAPIHRDSDQHAQLEIGIEFNLDLRPEDLEVIKDLGSGNGGTVSKVRHIPTNTVMARKVIHVEAKREMRKRIVRELQIMHSCNSEYIVTFYGAFLNENNDVIMCMEYADVGSLDRVSRVFGPIRVDVLGKIAEATLGGLTYLYAKHHIMHRDIKPSNILVNSRGSIKLCDFGVSGELINSIADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLSIMELAIGKFPFAASEQLSDAESAPAGILDLLQQIVHEPAPKLPKSDAFPQILEDMIQKCLYKNPDDRPTPEELFERDPFVQAAKRTPVDLREWAFGLMERDNRKSHLAPQLSPATADLLRSSDSPTATYHGDDRPLETPTSAYRVDPRRGPAEGSAGLADQVDRLYIRD
Protein: Unc-13, isoform C (Q9V483)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTHYVRHDYFHNTQNGALSSDTSRISYSQISYETQPSREYFSESYALSNQGPEECSRVSHLNSDTVLTTVDNSNNSYGYDYLECYGANIQCDPEEDSVDNWNENTSVVADQYGLGHNNLNCTSSKLLPKLPNIENGRGSSNACAPQMDVKFNTKGMCIKIDHSYGVCMAKAHDFVGRLSPSDYQNILGNNLNGYAGCAYSSTFLDNAMSSAPLRVLPQSPRCSSYLGRNIIGFNADAAQRDGRGFDTDQTDAMGSESSTYEVYEKMQRPYTSMLPLDYSDYQEGCYNTDNLSTYSDTPPSNNTQLKRQMQRKISLMMAMTTASVIASGEIRVPVHSKQSKKSTEIQTDSIIGNTISTNAAARDLDRCLATESCEVIVDTRDSGSVTSFPSSAVTAITKTRKLPKVLPTPLCKSSRHPITIATDALSSSYTSDPLPEKSHRPKQLPKLPISLPQSNDRASLNSNWATPPAPDALPFNSFDHKSASSPTPTTTITKDTETTSYLVETDFIGARHNALYQYDSKEPNIVFSDKSVEAEHSPTWTPLSPIQSKQSPCPPVALPSNIMQNVSLTCHLPEIEATRSDIEREPESSSIEPILEIEKLADPYSGPGSALFNISEYLKPYTLNKPILSEEKKNHIANAASTSTTTPLNITSDDEFSSYSNKWTSTCVNFQPLDVESSLNISLKVNAGTNQAELLMTPLKSSTPLFISSNGTSDNFNLRKSSPPDSAFTTTVNVNSFETVLVSGSQTASPSPSNLKSPPSIAPLLSYSDYMKQFELPELPQPIMDLSENDTATQSDSFNVINNTLTNADNLNSYNQMDVESKSSLQLPSYSSESFDPCSVPSFSIKNKEYKIVEKLDSLSNVESVESPKTLVSPVNPLNCSKLLPGTESIVSNDVAFDDTFYDSFNVDIKELTAFVDHVAPEDGLYNFPNDKTSVEFSFDKTEDTIDMNQNLSSGECGYYKPSQAQQKASVVASAASSVLDGISKGLKGGLDGVFSGVSSTVDVTQSNPSSKRGFSFNLASKIVPSVGGLLTSTSSTSIKQTGSETNPTLILISPENVSSRNSNYIPTTSPSCTQKNGEENLYSATVHNKSTKSNSYYNEVGEISSTLVRNVCDSYDNSYDEMILTNEMVNIGMLDSESEFGLIENSYSYQVPDNEQIDSVNSYNNKTQNVTNNGIEKANTKNKPVPLHDPPTKKASTVGMFGSILGKAAAAVQSATQAVNQSASSVASVVAQKPTIVPRTNNVLLLSSVCSPNEIKRNSSSVEFDSEYGYQMPDVESLSSHYANTGGDYDNSNMKIHEFGTYADDRPYADYHTNGNQSQFKEEAVIPGEPEVINTNILPIGPQATGKKLPTVNGKSALLIKQMPTEVYDDESDTDELDVSPSTGKVPSYSIYSEQEDYYMDLQQTTPSIQPNGFYEQVNNGYDYREDYFNEEDEYKYLEQQREQEEHNQPKNKKYLKQAKISKIQPPSLDFIDVGQDDDFIYDNYHSEDDSGNYLEGSSSGSVGPIEGSIIKVDSNIEASFASLNKKSDSFTPTNDSLQKHDTVIGESTTKLTRLRTEKMCPDVDEEDENLSDHVSDLTDLSKLISQKKKTLLRGETEEVVGGHMQVLRQTEITARQRWHWAYNKIIMQLNNGGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAVPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCEENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPEHMKDERIACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQNLNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGGSGTLAAGNLAAQRNAVAVEADEVLRPLMDLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEKTIVLPPMTDKTMMFKHLTDNAKNLASNAKIEDMGRLFKSHMAGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKTFISSQVHEVDLENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAANDLKWQIPSGMFRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHICVKDYCFARDDRLVGVAVIPLKDISEKGSVACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFVKLKSEIRQEPTMGT
Protein: Branchpoint-bridging protein (A3AT67)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367126}.
Interaction partners:
Sequence:
MKDFAADLDPEVHNLNARLLEISRMLQSGLPLDDRPEGARSPSPEPVYDNLGIRINTREYRARERLNRERQEIISQLIRRNPAFKPPADYRPPKLQKKLYIPMKEFPGYNFIGLIIGPRGNTQKRMEKETGAKIVIRGKGSVKEGKLLQKRDMKPDPSENEDLHVLVEAETQEALDAAAGMVEKLLTPVDEVLNEHKRQQLRELAALNGTIRDDEFCRTCGEPGHRQYACPNRTSTFKSEVQCKICGDGGHPTIDCPVKGTTGKKMDDEYQNFLNELGGSAPESVTKSSGPMLALTGSGGSGGSSGGVGAGSGSNPPWAAGGGAAASGANGIKKEYDETNLYIGYLPPTLDDSGLIGLFSQFGEIVMAKVIRDRITGQSKGYGFVKYSDVSQANAAIAAMNGYHLEGRVIAVRVAGKPPQPAVPPGPPAVPAPPTYPPADPAAGGYTSQPYMGAPPPPPPGSYAPVPWGQPPPYASYPPPPPGSSMYNPPPPAPGQATPPPYGVQYAPPPAPIPPPGTAPSTDGAQNYPPGVTPPSSGAPTQPVPAPVYGTSGAPNAPPMYPPPPYGYASYYPSVTPVQPPPPPPPAGADPSQSLANAPWATHSAPPPPPSGADPSQSIANAPWATHSAPPPPPATADHSQSIASAPWATHNAPPPPPPPSSIEQPPATYGADAEYDKFMSEMK
Protein: PAR-domain protein 1 zeta (PAR-domain protein 1, isoform N) (Q5U8V5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDRERSSPTLIETGLKNLIGGRDGNYPLISGINGRKSPFLGFICKSNGKSTSNSKEIICPDDKYKEEGDIWNVEAQTAFLGPNLWDKTLPYDADLKYADLDEFLSENNIPDGLPGTHLGHSSGLGHRSDSLGHAAGLSLGLGHITTKRERSPSPSDCISPDTLNPPSPAESTFSFASSGRDFDPRTRAFSDEELKPQPMIKKSRKQFVPDELKDDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKENATLHQEVEQLKQENMDLRARLSKFQDV
Protein: Uncharacterized protein (Q583U6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MELNELQRLAAAFDEQGMRYTFTASEHPSTPGVYRFVFSRPTNAAPESAVYINADITRAPNQNGRGDADDAATYRVMIEGLRWPYYIKLRDGIVDEGGFPESLLERVDLQKCKVNERCLWT
Protein: Ribonuclease pancreatic beta-type (EC 4.6.1.18) (RL1) (RNase 1 gamma) (RNase A) (P00684)
Organism: Rattus norvegicus (Rat)
Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Lysosome-associated membrane glycoprotein 2
- Heat shock cognate 71 kDa protein
- Ribonuclease pancreatic beta-type
Sequence:
MGLEKSLFLFSLLVLVLGWVQPSLGGESRESSADKFKRQHMDTEGPSKSSPTYCNQMMKRQGMTKGSCKPVNTFVHEPLEDVQAICSQGQVTCKNGRNNCHKSSSTLRITDCRLKGSSKYPNCDYTTTDSQKHIIIACDGNPYVPVHFDASV
Protein: TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) (O60343)
Organism: Homo sapiens (Human)
Function: May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18771725}. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Interaction partners:
- RAC-beta serine/threonine-protein kinase
- RAC-alpha serine/threonine-protein kinase
- Leucyl-cystinyl aminopeptidase
- Solute carrier family 2, facilitated glucose transporter member 4
- Ras-related protein Rab-14
- Ras-related protein Rab-10
- Ras-related protein Rab-8A
- RAC-gamma serine/threonine-protein kinase
- 14-3-3 protein zeta/delta
- Ras GTPase-activating protein 1
Sequence:
MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
Protein: SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) (Q9BQI5)
Organism: Homo sapiens (Human)
Function: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
Subcellular location: Membrane, clathrin-coated pit {ECO:0000305|PubMed:20946875}; Peripheral membrane protein {ECO:0000305|PubMed:20946875}; Cytoplasmic side {ECO:0000305|PubMed:20946875}.
Interaction partners:
- Epidermal growth factor receptor substrate 15
- Intersectin-1
- AP-2 complex subunit alpha-1
- Epidermal growth factor receptor substrate 15-like 1
- AP-2 complex subunit beta
- AP-2 complex subunit alpha-2
- RalBP1-associated Eps domain-containing protein 1
- AP-2 complex subunit sigma
- Intersectin-2
- AP2-associated protein kinase 1
Sequence:
MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPHEPPYNSKAECAREGGKKVSKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGPVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPGPTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPPPTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN