wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 950 (A0A0U1RQ46)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDAVTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLTAIGYNWDDHNIEEHCQSSRRHGRHETSHPGEKPSQYTHCGKAFVYWSHPQRHERIHTGEKPYGCNHCGKAFAHHSNLQRHERIHTGEKPYECNQCGKAFVTHSDLQIHKRTHTGEKPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNKCGKAFAWHSHLQRHEITHTGEKPYECNQCGKAFAHDSNLHIHKRKHAGEKPYECNQCGKAFPCYNLLQIHKRTHTGEKPYECNQCGKTFAYHSYLQMHERIHTGEKPYECNHCGKAFSQHSSLRVHKRTHTGEKPYECNQCGEAFVYHSHLQIHKTMHTGEKPFQCNQCDKAFVYNNHLLVHKRIHTGEKPYECNHCGKAFSQLSGLHVHKRTHTGEKPYKCNECGKAFARNSHLQRHKRIHTGEKPHECNQCGKAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHKRTHTGEKPYECNQCGKTFAYHSHLQVHGRIHTGEKPYKCNQCGKAFACHRNLRVHKRKHTGEKPYEFNHYSKAFSQHSSLQVHKRTHIGEKSYEL
Protein: Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) (Q8IZP0)
Organism: Homo sapiens (Human)
Function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Actin-binding protein WASF2
- Protein BRICK1
- Nck-associated protein 1
- Nck-associated protein 1-like
- Epidermal growth factor receptor kinase substrate 8
- Cytoplasmic FMR1-interacting protein 2
- Actin-binding protein WASF1
- Cytoplasmic FMR1-interacting protein 1
- Tyrosine-protein kinase ABL1
- Son of sevenless homolog 1
Sequence:
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Protein: Pentalenolactone F synthase (EC 1.14.11.36) (Pentalenolactone biosynthesis protein D) (E3VWI8)
Organism: Streptomyces arenae
Function: Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent oxidation of pentalenolactone D to pentalenolactone F in the biosynthesis of pentalenolactone antibiotic. Also able to catalyze the oxidation of pentalenolactone D to pentalenolactone E.
Interaction partners:
Sequence:
MEVTPIPGAPLGAVVHGARVTGDMDKTHLEEIWSALDTYLVLVLRGHETPSYEEFLAFGRRFGHIPKTGLTSGAHPEHNEILIVSNLVEDGRKIGVGDAEWMGWHTDYSFRPRVSQVGFLEAVEVPYSGGGETLFTDMYALYESLSPEERRRLHSFRVRHALRTGYEETIEEELQREVTLGEGADRIQPEDGTSTVHPLIARNPRTGRRSVYISTLNTERIVDLAPDDSRELLDGLLAHAGKPQYTYAHTWQPGDLVVWDQLGTVHAKQAFDPAERRVMRQVVSIFDDPAGPWRAEAAA
Protein: 30S ribosomal protein S9, putative (Q8ILW1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Mitochondrial ribosomal protein S5, putative
- 30S ribosomal protein S2, putative
- 40S ribosomal protein S18, putative
- 40S ribosomal protein S19
- Mitochondrial ribosomal protein L20, putative
- 40S ribosomal protein S11, putative
- 40S ribosomal protein S5, putative
- Ribosomal protein L27, putative
- 60S ribosomal protein L23
- 60S ribosomal protein L11a, putative
Sequence:
MFFNHVKSYIILFILFCSYYINGRGVNRIYKNCGRKKLGNIFCCANIICVKERVKKIKHIDRWEYKRKKRKNINIFLYIPIKKDINKMKYYNFRNIVINDFFFFINKYVCASKIINIHSKCRKKFVLFKKDKGSDKSNNALKKKDKKTFSEEEIEELRKKAKEKSQANRSISEESKRKKSIEKGMKRKRYIKNQKQVKKKKSTSDEEEKKKKELKDKDDTKENVDDGDDIYLRKSKESKDKIQKDEDLNSYIGTIDDFEKISNVTKNIINEKEVEYLQKIIDCDDALLKYDKREKNVKLNIEDTIFDEGNYMEHYINNISKFRYDIYNLHNKNEFDRLTKYLNYQYVEEIPITFPTDKNYHIKLKKYFYESVCDLINKYKHRFQNYTLQQENMSDSHDKMGTIVQNDATNISMEKRNINLYNDTKGISQNNMVLENFIRENEKEKMETQTHSTINKIEEGVTNPYDKSEENIMKKYMTFDLYNVLCDVKEEYEYMFDNGGIEKFSFDKNRIKNKEKLIFSGKKKRALAQVFLERGNNNLIINNRDGYQYLQYQILNLNKIFSPLLNLCLHRHFNIVAKVEGGGLSGQSVAIFHALVKYIVYNFSLKIKPFFRSLNFMTVDTRKVERKKYGLKKARKKKQYSKR
Protein: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) (P78356)
Organism: Homo sapiens (Human)
Function: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
Interaction partners:
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Sequence:
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
Protein: C3H1-type domain-containing protein (Q38A89)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPVHAHAMWNSLCFYKAYLPPEDTVRATGYVVLALEEPEEEVSPVPRENSNERGVSPSLSHLDWPDDGALFPGDRLTAGAATNSSQLSDLPPSHERSVMDRDTKLQFFLFRKEDVSPPYMKGMLGKIRHCFLLCLQGDRGNPCHCHRAHLLNEDAWRLKLSSFDFSTLCVSSNFSLRYIDVTHVRPTAGFLFTCGLLHERIIVAAQPILCRYNDKCRYGSQCLFVHADIGGDNLTKTTAATPLRNLLPPQEGLDTFLAQLEEVELQTVGDVQRLSTKAFDAFVGGCEPQWTPLWLNISIFREIQPKASLESVLISFPGVTAPVVLPPNLTNVLSLLDMSQKDFYKLKLTINVQAACEKIRARFWSSRDYRTLDLKREGAKSFFTNITLEILQFRSTMADCSWRKKDPMRQVVTSLMTYVDHKKCHCNVTCGSRRHWSMHKPALSSNGNGMSNATFPDHSWCTCPRSTVMAVNYELSTPSGSRCSEQNALGKLASMGLPTCAVREVFVHGEHQGSKKDPNPLFPCGVCENMLRKVAHDVLEIHGGDVMLYMYDSTHNPKRLVYLPITEISYRDDMGFREFVADLHE
Protein: Double-stranded RNA-binding protein Staufen homolog 2 (Q7ZW47)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein required for the microtubule-dependent transport of RNAs within polarized cell types.
Interaction partners:
- Endoribonuclease Dicer
- Regulator of nonsense transcripts 1
- Drosha ribonuclease III.
- Protein argonaute-2
- Synovial sarcoma, X breakpoint 2-interacting protein b.
- Ubiquitin-conjugating enzyme E2 variant 3
- Cytoplasmic polyadenylation element-binding protein 1
Sequence:
MANPKEKTPMCLVNELARFNRIQPQYKLLNEKGPAHAKIFTVQLCLGNQVWESEGSSIKKAQHSTATKALAESSLPRPPPRSPKADSNSNPGSITPTVELNGLAMKRGEPAIYRPLDPKPIPNYRANYNFRGMFNQRYHYPVPKVFYVQLTVGNNEFIGEGRTRQAARHNAAMKALQALKNEPIPERPPQCSEEKKETEENSDASKSEISLVYEIALKRNLPVNFEVLKESGPPHMKSFLTRVTVGEFSAEGEGNSKKLSKKRAALSILQELKKLPVLPVVEKPKVHYKKRPKTILKTGPEYGQGMNPISRLAQIQQAKKEKEPEYMLLSERGMPRRREFIMQVKVGTEVTTGTGPNKKVAKRNAAEAMLLQLGYKASTPLQNTPEKMDNKGWNGQRAAFPETTSNTQKGILHLSPDVYQEMEASRNKGVPGAPGNFPTAKEIGQGSAGPFCTPSVGNTATIAKELLLSGTSPTAEALVLKGKAPALACGSIQPSQQLEYLAHIQGFQVQYSDRQTDKEFMTYLTLSPVQMTFHGIGSSIPASHDQAALSALKQLSEQGLDPVDGPIKVENGSCDIQAKRLAERTESKPTNSGTTAQDCKDSKAVV
Protein: NADPH oxidase regulator NoxR (A0JC82)
Organism: Epichloe festucae
Interaction partners:
Sequence:
MSLKLEIETWVAALARYDNNEFDDALGEFDKICDTSKILFNMGVIHATLGEHEKAVECYQRAIRLDQYLAVAYFQQGVSNFLLGDFEEALANFNDTLLYLRGNTMIDYAQLGLLFKLYSCEVLFNRGLCYIYLQQQDVGMQDLTYAVKEKVVEDHNVIDEAIREEAEGYTVFSIPVGVVYRPNEAKVRNLKTKDYLGKARLVAASDRSNAFTGFTGSEIKNAGKMEVKDDRPADNISFAATNLVKPGIQSRRQQPEPSANRNVFPPTPPPDNDRPSRGSSVRNGSRPMPAKLTIQTQDSNRKYEKAPSPEEVRATRSAASSTPSQGFSRRDHPPIQRRPTRRIDEMEEADAGDLYDMYQGSGSNRRTSRDSRRPSVRSRTQPRYYDDDDGSDYDDGSLDGAEFEMVSNNRRRQGSRSESRATSRRPEIRKIRVKVHAGDVRYIMIGAAIEYPDFVDRIKDKFGMKRRFKIKIPDEDMPDGDMITVGDQDDLEMAIQSSTSLAKRQRQDVAKMEIWIFEL
Protein: Fibrinogen gamma chain (O93568)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MMGVKSVTSRLAVGDLLSLLFSTSMAYIATRENCCILDERFGSYCPTTCGIADFFNKYRLTTDGELLEIEGLLQQATNSTGSIEYLIQHIKTIYPSEKQTLPQSIEQLTQKSKKIIEEIIRYENTILAHENTIQQLTDMHIMNSNKITQLKQKIAQLESHCQEPCKDTAEIQETTGRDCQDIANKGARKSGLYFIKPQKAKQSFLVYCEIDTYGNGWTVLQRRLDGSEDFRRNWVQYKEGFGHLSPDDTTEFWLGNEKIHLITTQSTLPYALRIELEDWSGKKGTADYAVFKVGTEEDKYRLTYAYFIGGERGDAFDGFNFGDDPSDKSYTYHNGMRFSTFDNDNDNFEGNCAEQDGSGWWMNRCHAGHLNGPYYIGGVYSRDTGTNSYDNGIIWATWRDRWYSMKKTTMKIIPFNRLSIDGQQHSGGLKQVGDS
Protein: Candida glabrata strain CBS138 chromosome A complete sequence (Q6FXU9)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Candida glabrata strain CBS138 chromosome F complete sequence
- 26S proteasome regulatory subunit 8 homolog
- Proteasome subunit beta
- Candida glabrata strain CBS138 chromosome I complete sequence
- 26S proteasome regulatory subunit RPN11
- proteasome endopeptidase complex
- 26S proteasome regulatory subunit 6B homolog
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome I complete sequence
Sequence:
MSGGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNLNSLAVRGKNCSVIINQKKVPDKLLDPSTVSYIFKISKTIGMVANGPIPDARNAAARAKGEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFISVDEELGPSIYKCDPAGYYVGYKATATGPKQQELTTSLENYYKKKNVGSHLDMEEWEKVVEFGITQMIDSLGTEFSKKDLEIGVATENKFIILTPDEIEERLVAIAEQD
Protein: Nuclear factor of activated T-cells 5 (NF-AT5) (Rel domain-containing transcription factor NFAT5) (T-cell transcription factor NFAT5) (Q9WV30)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (By similarity). Mediates the transcriptional response to hypertonicity (By similarity). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (By similarity). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:11934689}. Cytoplasm {ECO:0000269|PubMed:11934689}. Chromosome {ECO:0000250|UniProtKB:O94916}. Note=Nuclear distribution increases under hypertonic conditions (PubMed:11934689). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (By similarity). {ECO:0000250|UniProtKB:O94916, ECO:0000269|PubMed:11934689}.
Interaction partners:
- Signal transducer and activator of transcription 3
- Transcription factor Jun
- Cyclic AMP-responsive element-binding protein 1
- Forkhead box protein P3
Sequence:
MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPPRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTGNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLDSQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNVDKVTILPNALITPLISSSMIKTEDVTPMEVTSEKRSSPIFQTTKSIGSTQQTLETISNIAGGAPFSSPSSSSHLTPESENQQQLQPKAYNPETLTTIQTQDISQPGTFPAVSAASQLPSSDALLQQATQFQTREAQSRDTIQSDTVVNLSQLTEASQQQQSPLQEQAQTLQQQIPSNIFPSPSSVSQLQSTIQQLQAGSFTGSAAGGRSGSVDLVQQVLEAQQQLSSVLFSTPDGNENVQEQLNADIFQVSQIQNSVSPGMFSSAESAVHTRPDNLLPGRADSVHQQTENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSAASASGSLQQSPVYQQPSHMMSALPTNEDMQMQCELFSSPPAASGNETSTTTTPQVATPGSTMFQTPSSGDGEETGAQAKQIQNSVFQTMVQMQRSGDSQPQVNLFSSTKNIMSVQNNGTQQQGNSLFQQGSEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSIFHSPNPIVHSQTSTASSEQLQPSMFHSQNTIAVLQGSSVPQDQQSPNIFLSQSSINNLQTNTVAQEEQISFFAAQNSISPLQSTSNTEQQAAFQQQPPISHIQTPILSQEQAQPSQQGLFQPQVALGSLPPNPMPQNQQGPIFQTQRPIVGMQSNSPSQEQQQQQQQQQQQQQQQQQQQQSILFSNQNAMATMASQKQPPPNMMFSPNQNPMASQEQQNQSIFHQQSNMAPMNQEQQPMQFQNQPTVSSLQNPGPTQSESPQTSLFHSSPQIQLVQGSPSSQDQQVTLFLSPASMSALQTSINQPDMQQSPLYSPQNNIPGIQGSTSSPQPQATLFHNTTGGTINQIQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAINQQGQPQNEGQSSVTTLLSQQMPETSPLASSVNSSQNMEKIDLLVSLQSQGNNLTGSF
Protein: Transitional endoplasmic reticulum ATPase (EC 3.6.4.6) (Valosin-containing protein) (Q5ZMU9)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- UBX domain protein 7.
- NSFL1 cofactor p47
- UBX domain protein 6.
- Uncharacterized protein.
- Ubiquitin recognition factor in ER-associated degradation protein 1
- UBX domain-containing protein 2A
- Ataxin-3
- Ubiquitin thioesterase OTU1
- Nuclear protein localization protein 4 homolog
- Small VCP interacting protein
Sequence:
MASGSDSKADDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQAKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLDFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGTGGGSGGNVYSEDNDDDLYG
Protein: Cartilage-associated protein (O75718)
Organism: Homo sapiens (Human)
Function: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Prolyl 3-hydroxylase 1
- Peptidyl-prolyl cis-trans isomerase B
- Collagen alpha-1
- Collagen alpha-2
- Serpin H1
- Peptidyl-prolyl cis-trans isomerase FKBP10
- Trimeric intracellular cation channel type B
- Interferon-induced transmembrane protein 5
- Protein disulfide-isomerase
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Sequence:
MEPGRRGAAALLALLCVACALRAGRAQYERYSFRSFPRDELMPLESAYRHALDKYSGEHWAESVGYLEISLRLHRLLRDSEAFCHRNCSAAPQPEPAAGLASYPELRLFGGLLRRAHCLKRCKQGLPAFRQSQPSREVLADFQRREPYKFLQFAYFKANNLPKAIAAAHTFLLKHPDDEMMKRNMAYYKSLPGAEDYIKDLETKSYESLFIRAVRAYNGENWRTSITDMELALPDFFKAFYECLAACEGSREIKDFKDFYLSIADHYVEVLECKIQCEENLTPVIGGYPVEKFVATMYHYLQFAYYKLNDLKNAAPCAVSYLLFDQNDKVMQQNLVYYQYHRDTWGLSDEHFQPRPEAVQFFNVTTLQKELYDFAKENIMDDDEGEVVEYVDDLLELEETS
Protein: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Q8T2T5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Succinate dehydrogenase cytochrome b small subunit
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Fumarate hydratase, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH-ubiquinone oxidoreductase 49 kDa subunit
Sequence:
MFGRTLNTFTSRNAPLVRNFDKFIVNNTLTSKNIYLSQTNTTNTPLSYSTQAKKPFTITEKRIDELKTPYQPTSPHLTIYKFPLPAVMSIMHRATGICLALGITGLAGVTLFAPHDAIHYIQLLHTQYPALVYPAKFAVALPLTYHFCTGVRHIIWDETVKGLSISQIESSGKVLLAVVAVLSTIFTFVSFK
Protein: Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) (O43900)
Organism: Homo sapiens (Human)
Function: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. Cell membrane {ECO:0000250|UniProtKB:A8WH69}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WH69}; Cytoplasmic side {ECO:0000250|UniProtKB:A8WH69}. Mitochondrion {ECO:0000269|PubMed:32516135}. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). {ECO:0000250|UniProtKB:A8WH69}.
Interaction partners:
- Vang-like protein 2
- Segment polarity protein dishevelled homolog DVL-1
- Vang-like protein 1
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Ankyrin repeat domain-containing protein 6
- Cadherin EGF LAG seven-pass G-type receptor 1
- Voltage-dependent L-type calcium channel subunit alpha-1F
Sequence:
MFARGSRRRRSGRAPPEAEDPDRGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERIMCRLISDFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEGRHWHMDHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQHWHASDRCFCCSRCGRALLGRPFLPRRGLIFCSRACSLGSEPTAPGPSRRSWSAGPVTAPLAASTASFSAVKGASETTTKGTSTELAPATGPEEPSRFLRGAPHRHSMPELGLRSVPEPPPESPGQPNLRPDDSAFGRQSTPRVSFRDPLVSEGGPRRTLSAPPAQRRRPRSPPPRAPSRRRHHHHNHHHHHNRHPSRRRHYQCDAGSGSDSESCSSSPSSSSSESSEDDGFFLGERIPLPPHLCRPMPAQDTAMETFNSPSLSLPRDSRAGMPRQARDKNCIVA
Protein: Mevalonate kinase (Q65XY0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MVVIGGDQALDSPSGSTSRAGSSVSATASPMHRNTTSQHGGLFVSAPGKIILFGEHAVVYGRTAIAGSIDLRTYVSLYTSADGRIYLSLPDLGVEKTWMLKDLLKAADRLAAEYPIEEDQPPSLEILVPIARKLSGSCEDQCGVQHLAILAFWYLLLGVAHRKRDLLAVKATVRFKLPSCVGLGSSGAYCVCIATSLLQTAGLIPPPSIVADEQGNLTWEEDHLDIIRKWATAAESLIHGRASGLDAAVCTFGGVASFKPGHRIEHLKNLPDLRVILVNSKVERNTARMVQTVKERLKKFPEVVDAMFGSIDAISLDAAKILHRPLLEENGGGDTGSTVQENGLGPFGGNMVEQDHHSLQPTRTASVRSSSLSSYVGGGKRNSSASVISATSEKGENVDTFSKLNDLCRINNQLLIALGVGHPKVDLICTTLARYGIHPKMTGAGGGGSVFAFLKPNTPQTLLDMIDGELRSHGFEVWQPPLGGPGVVEHQTRPELFQTPVSSTQCSTPASKHK
Protein: Uncharacterized protein, isoform B (M9PEB5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKAS
Protein: Putative clathrin assembly protein At1g14910 (P94017)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane, clathrin-coated pit {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Note=Colocalized with clathrin in the Golgi area. {ECO:0000250}.
Interaction partners:
- Ribosome biogenesis protein NOP53
- Reverse transcriptase
- Nonsense-mediated mRNA decay factor SMG7-like
- F21D18.12
- MADS-box transcription factor family protein
- MADS-box transcription factor family protein
- AT4g03420/F9H3_4
- At5g27810
- Clathrin interactor EPSIN 3
- MADS-box protein AGL35
Sequence:
MGTLQSWRRAYGALKDTTKVGLVRVNSDYAELDVAIVKATNHVECPPKDRHLRKIFLATSAIRPRADVAYCIHALSRRLHKTRNWTVALKALLVIHRLLRDGDPTFREELLNFSQKGRIMQISNFKDDSSPVAWDCSGWVRTYALFLEERLECFRVLKYDIEAERLPKVSPGQEKGYSKTRDLDGEKLLEQLPALQQLLHRLIGCKPEGAAKHNHIIQYALSLVLKESFKVYCAINEGIINLVEKFFEMPRHEAIKALEIYKRAGLQAGNLSAFYEVCKGLELARNFQFPVLREPPQSFLTTMEEYMRDAPQMVDVTSGPLLLTYTPDDGLTSEDVGPSHEEHETSSPSDSAVVPSEETQLSSQSPPSVETPQNFIDTDDLLGLHDDTPDPLAILDQNALALALVSNDVDSSPFSFGQARDLDPSGWELALVTTPSNDISAATERQLAGGLDTLTLNSLYDDGALRAAQQPAYGVPASNPFEVQDLFAFSDSVSPPSAVNNPFGLYEPTYHQQEQQPQLQVAPSPANPFGDFGEFPIVPVSEPQSTTSFGAFPVPVSEPSNTTGFGEIPVVPVTEPPNTTAFGEFPVVPVSEPQNITGFGALPVTPASEPSNTTGFGEFPVVSVSAPQNTTGFGALPVIPVSEPSKTTGLGEFPVVPVSEPQNTTGFGEFPVNAGAHEQHNSNNPFGSTGFL