wanglab/gogpt-training-data huggingface dataset:
Protein: Radixin (P35241)
Organism: Homo sapiens (Human)
Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus {ECO:0000250|UniProtKB:P26043}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P26043}. Note=Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (By similarity). Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. {ECO:0000250|UniProtKB:P26043}.
Interaction partners:
- CD44 antigen
- Ezrin
- Moesin
- Na
- Leukosialin
- Sodium/hydrogen exchanger 1
- Intercellular adhesion molecule 2
- Na
- P-selectin glycoprotein ligand 1
- Chloride intracellular channel protein 5
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Protein: glutathione transferase (EC 2.5.1.18) (B8JIS5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Glutathione S-transferase theta 1b.
- glutathione transferase
- Glutathione S-transferase omega 1
- Microsomal glutathione S-transferase 1
- Glutathione S-transferase rho
- Glutathione S-transferase 3, mitochondrial
- Glutathione S-transferase omega 2.
- Glutathione S-transferase 3, mitochondrial
- Maleylacetoacetate isomerase
- Microsomal glutathione S-transferase 1
Sequence:
MAMKLAYWDIRGIAQPVRLLLEFTGTKYEEKFYSCGEAPDYDKSCWFNEKNKLGLAFPNLPYLEDGDTKVVQSNAILRYIARKNNLCGETEEEQTRVDILENQAMDFRNGFIQLCYGDFDKNKPCYCEKLPGSLKQFSDFLGDRKWFAGDKITFVDFIMYDLLDLHRMLHPECLDDYRNLRSFLDHFESLEKIVAYMKSNKYMKTPVNNKMAKWGNKKE
Protein: E3 ubiquitin-protein ligase RNF170-like protein (DUF 1232) (F4I1E4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MRHRRTNFVRYAMATSTLLANPIALTGSAVRSPSYLLSFLLLSNRFGIGNCIMLVWRHGSTLRPCKCPLCRRPISLLVPSEETVRSRNDATVSEVLHDVETYNRVFGGQSSGLIQRMQDLPFLLRRLLREMMDPQRTLPLVIRARVYIALILSAIYIISPIDIIPEGVLGVIGLLDDLLIALICFLHVAALYRSVLYSRHGGS
Protein: Neuronal acetylcholine receptor subunit beta-2 (P17787)
Organism: Homo sapiens (Human)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:P12390}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuronal acetylcholine receptor subunit alpha-4
- Neuronal acetylcholine receptor subunit alpha-3
- Neuronal acetylcholine receptor subunit alpha-2
- Neuronal acetylcholine receptor subunit alpha-7
- Neuronal acetylcholine receptor subunit alpha-9
- Neuronal acetylcholine receptor subunit beta-4
- Tyrosine-protein kinase JAK2
- Neuronal acetylcholine receptor subunit alpha-5
- Neuronal acetylcholine receptor subunit beta-3
- Acetylcholine receptor subunit alpha
Sequence:
MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
Protein: Lung seven transmembrane receptor family protein (Q8GYD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein ALTERED XYLOGLUCAN 9
- 3-oxo-5-alpha-steroid 4-dehydrogenase
- Probable inactive purple acid phosphatase 2
- Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 7
- Transmembrane 9 superfamily member 12
- RING-type E3 ubiquitin transferase
- Rhomboid-like protein 15
- Protein RETICULATA-RELATED 2
- Ribosomal RNA small subunit methyltransferase J
- Probable protein S-acyltransferase 13
Sequence:
MKNRSLGFWAIGVLLIGSLIGATEGSIHEYNNEKFTAKFNARFFHGGSEGLYASKSQDLNSSSSSDNSFKGKSFIRFDDVTFVRTKESASKQNAMQSTSGLVEAIILEVKDRDRIGGTFLKSEVICCTPELADTGSCSLGEVIIKRESNDVEWPRQIKTFFKGNKTEVNMSPETVVINKTGMYYLYFMICDPELDGTRIKGRTVWKNPDGYLPGKVAPLMNVFGFMSLAYILLGLVWFVRFVQFWKDIIQLHYHITLVIALGMCEMAVRYFEYVNFNSTGMRPMDVTLWAVTFSSIKKTLSRLLLLVVSMGYGVVKPTLGGITSRILLLGVIYFVATEALELVEHLGNINDFSGKTMIVLVIPVALLDACFILWIFSSLARTLEKLQIKRNMAKLELYRNFTNALAISVLLSIAWIGFELYFNGTDPLIELWRMAWIIPAFWNLLSYGLLAVICILWAPSNNPTRYSYLAETGDEFEEEGISLTGSGIKSTEDVERNELLFGLPDDVEEGKRE
Protein: RNA helicase (EC 3.6.4.13) (Q7ZU28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MATDSWAQAVDEQEAAAESISTLQISEKEEKPTAEANGAKTEAKTEAKTEANADKTEEDDKDDKAAQSLLNKLIRSNLVNTTNQVEVLQRDPSSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQETALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSHVDPENKWPQCLCVSPTYELALQTGKVIEQMGKHYPEVQLVYAIRGNKLERGTKLQEQIVIGTPGTVLDWCQKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPKTCQMLLFSATFEETVWNFAKRIVPDPNIIKLKREEETLDTIKQYYVICNSKEEKFQALCNIYGAITIAQAMIFCHTRKTAGWLAGELSREGHQVALLSGEMQVEQRAAVIERFRDGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAINMVDSKFSMNILNRIQDHFNKKIEKLDTDDLDEIEKIAN
Protein: Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) (O60936)
Organism: Homo sapiens (Human)
Function: May be involved in RNA splicing.
Subcellular location: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:10196175}. Note=The SR-rich C-terminus mediates nuclear localization. {ECO:0000269|PubMed:10196175}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10196175}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}.
Interaction partners:
- Caspase-8
Sequence:
MGNAQERPSETIDRERKRLVETLQADSGLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRTAGAPDPAWDWQHVGPGYRDRSYDPPCPGHWTPEAPGSGTTCPGLPRASDPDEAGGPEGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFEERDESEDS
Protein: dihydrofolate reductase (EC 1.5.1.3) (B7VPW7)
Organism: Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32))
Interaction partners:
- Thymidylate synthase
- Methionine synthase
Sequence:
MVWSSVRLAGSVLVHLMPGVSPMEINLKLSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGKLPNRKYAVISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKHISGDIFFPELPRDLTLVFEQRFSSNIDYTYQIWQKG
Protein: Glr1343 protein (Q7NKY3)
Organism: Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Glr1342 protein
- Gll0812 protein
- Gsr4153 protein
- Aquaporin Z
- Gll0383 protein
Sequence:
MSNENLFFQAFIYLAAAVVSVPIAKRLGLGSVLGYLLAGVAIGPFVLGLVGKEGEDVMHFAEFGVVMMLFLVGLELQPSLLWRLRVPILGMGGLQVIGTALVAGAIALVFGLSWQMSLAVGLILAMSSTAIVLQTLNEKGVMKSEAGQSAFSVLLFQDIAVIPILALLPLLATGKATEVSLQAAAGDLIFVAAGGASGPTAALPAWQQALLVIALLGGIVLVGRFLMQPVFRFIASTRLREIFTATALLLVVGVALAVQAVGLSPALGTFVAGVVLAENEYRHELETDIEPFKGLLLGLFFIAVGASINFNLLFEQPLLILGLVIGLAVVKFSVLLALGQFFRLQLSQSFLFAFALAQGGEFAFVLFSFATQNRVLTPEVAEPLVAVVALSMVMTPLLMILHDRLVQPRFVLTEPEREPDAIDENENPVIIAGFGRFGQIVGRMLMANGCKVTILEVDPSQIDMLRRFGFKLFYGDATRIDLLHAAGAQQAKLLVIAIDDREKSLEMVDLVRKHFPHLKILARAIDRRHAYELIRRKVDVVERETFGSAVEMGVGALKLLGERSYRAQRIASTFKANDEKMLYEMAELEEEERLVAVRSRRQAEELERVLRAEDRELTRDVERAWDVSDLRKEA
Protein: Neuroligin-1 (Neuroligin I) (Q62765)
Organism: Rattus norvegicus (Rat)
Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Postsynaptic density {ECO:0000269|PubMed:18434543, ECO:0000269|PubMed:19914352, ECO:0000269|PubMed:9927700}. Synaptic cleft {ECO:0000269|PubMed:9927700}. Synaptic cell membrane {ECO:0000269|PubMed:9927700}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. {ECO:0000269|PubMed:19914352, ECO:0000269|PubMed:9927700}.
Interaction partners:
- Neurexin-1
- Neurexin-3
- Disks large homolog 4
- Neurexin-2
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- SH3 and multiple ankyrin repeat domains protein 3
- Neuroligin-3
- Neuroligin-2
- SH3 and multiple ankyrin repeat domains protein 1
- Disks large homolog 3
Sequence:
MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVLSQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAPEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV
Protein: Beta-fructofuranosidase, insoluble isoenzyme 2 (EC 3.2.1.26) (Cell wall beta-fructosidase 2) (Invertase 2) (OsCIN2) (Protein GRAIN INCOMPLETE FILLING 1) (Sucrose hydrolase 2) (Q0JDC5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Cell wall-associated invertase that cleaves sucrose into glucose and fructose and is required for assimilated carbon partitioning during early grain-filling. May be involved in sucrose unloaded in the ovular and stylar vascular tissues for the stimulation of starch synthesis in the developing endosperm during grain-filling. Sugar homeostasis mediated by CIN2/GIF1 plays an important role in constitutive and induced physical and chemical defense against pathogens.
Subcellular location: Secreted, cell wall {ECO:0000305}. Note=Associated with the cell wall. {ECO:0000305}.
Interaction partners:
- fructokinase
- Fructokinase-1
- Sucrose synthase 4
- Alpha-galactosidase
- Os11g0672450 protein
- Hexokinase-4, chloroplastic
- Alpha-galactosidase
- Probable sucrose-phosphatase 3
- galactinol--sucrose galactosyltransferase
- Galactinol--sucrose galactosyltransferase
Sequence:
MGVLGSRVAWAWLVQLLLLQQLAGASHVVYDDLELQAAATTADGVPPSIVDSELRTGYHFQPPKNWINDPNAPMYYKGWYHLFYQYNPKGAVWGNIVWAHSVSRDLINWVALKPAIEPSIRADKYGCWSGSATMMADGTPVIMYTGVNRPDVNYQVQNVALPRNGSDPLLREWVKPGHNPVIVPEGGINATQFRDPTTAWRGADGHWRLLVGSLAGQSRGVAYVYRSRDFRRWTRAAQPLHSAPTGMWECPDFYPVTADGRREGVDTSSAVVDAAASARVKYVLKNSLDLRRYDYYTVGTYDRKAERYVPDDPAGDEHHIRYDYGNFYASKTFYDPAKRRRILWGWANESDTAADDVAKGWAGIQAIPRKVWLDPSGKQLLQWPIEEVERLRGKWPVILKDRVVKPGEHVEVTGLQTAQADVEVSFEVGSLEAAERLDPAMAYDAQRLCSARGADARGGVGPFGLWVLASAGLEEKTAVFFRVFRPAARGGGAGKPVVLMCTDPTKSSRNPNMYQPTFAGFVDTDITNGKISLRSLIDRSVVESFGAGGKACILSRVYPSLAIGKNARLYVFNNGKAEIKVSQLTAWEMKKPVMMNGA
Protein: SSD domain-containing protein (H1UBK7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Putative patatin-like phospholipase domain-containing protein M110.7
Sequence:
MRLPTAKYEVHMQKFFYKVGYFVGTHPRKCIGVLLLVTLVSCLGFLRFHQINNARVTFTAHDSPSHLEGAMFFEFLRQNGTLHMIEVMFQASDNGSLLRPPYRHELYEISKEIVEKLQVDVNGVNKTYGDMCEPYCEKNDAFFALMDIFESNSTDSFEITYPTTELLGHKILLANNLYGVETHPKTHRIQSFSAVILRFFLTFPNLKPMTDFEHEIVKLVYDSGKYPLIYGQVASDNLVAEEVRRLGTTTAPWLSVALAILGVFLMVCSLRYRRAESKPLEACLGALIPVLSGITTIGMVSATGLAFQSIIVSTLFLVIAIGIDDIFIILAAWHRTDKHLEIPERMALTVQEAGCSMTVTTVTNLVSFGNGVLSTTPVLQTFAIYSSVASVVCYIYQLVIFPAIIAITAPNEYQKLGDSKEEKTWDIIKTMGQWSDRQWHKLAGAISTSWVRLLTISILLGYWYLSVYGIATMETDLTIQKMADQNARIVKFKRDADIILKEMQSVAILVKSPKDLRKMENLKKLQKMIKDFESAKNSFGNESTVCWLQSYIDFLTFYQENDEEFDNDDVITENSAKKSNFSEEKPAKSRFQFTYSDLPAFLNSEPQYKPMIRYSESECVKNSEKCIESFIFTTGFTDVVKYNEMYPVVSEWRKIAANYSEFEVYPYTERSNFVDQTVDMVDNIWNTVISEVICMGLTFILFIPDLISIFSAVFALFSVNFGVFGFLSIWGVGMDPVSTASLLMSIGFSVDISAHISYHYYQVDKPTARQKLEHVYSHIGWPTLQGGLSTMLAMMPIVLAPSYLGMVFLKTVILVCTFGLIHGLIVLPVFLSFFTEISGFCRRKSVKIADSPSSSIDNLPKTISIRDIGSQKKYQKDHENNNNNIEKF
Protein: Complexin-4a (Si:ch211-233a1.5) (Q08BK6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Lectin, mannose-binding, 1.
- Complexin 2.
Sequence:
MAFLIKSMVGNPLKGMGLGGGDEKAEEETPKDPAAAAGMTREEYEEYQKQLVEEKMERDADFLHKKAERATLRVCLREKYRLPKSEQDENMLQMAGDDVDVPEELLKMVDEDATEEEEKDSIMGQIQNLQNMDMDQIKEKASATLTEMKSKAEEKCSVM
Protein: KCNQ potassium channel, isoform D (B7YZR3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLDEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKAKDVYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDIGVEVDVDADADGDCDESTEDTALLQCATRTAIVITPISPVSSAHNLQQLNDQTTTLNKSNLLPPDSG
Protein: CD209 antigen-like protein A (L0N7P8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MENDENTYANSSSFRASPREGAIYFQRWKRPSRAAAVCLGLLCVLLLAGIISLSFYQSNQSTSYNNLTKERDQLQKENENLNKKIKGRRCPEGWREFEFSCYYITNENKTWMQSSEECQELGADLVIINSKEEQVFINGLYQTKNNVWIGLTDSVTEGTWKWVDGTPLTTANWGRGQPNGNNGTDQDCGEFVYHPTSQGWWNDEKCSNKQNWICEK
Protein: Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) (P00568)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Exhibits nucleoside diphosphate kinase activity, catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P05081}.
Interaction partners:
- Adenylosuccinate lyase
- Adenosine kinase
- Adenine phosphoribosyltransferase
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- Deoxycytidine kinase
- Ectonucleoside triphosphate diphosphohydrolase 2
- Thiamine pyrophosphokinase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sequence:
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK
Protein: Transcription factor LG2 (Protein LIGULELESS 2 homolog) (OsLG2) (rLG2) (bZIP transcription factor 11) (OsbZIP11) (Q5N7C7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional regulator involved in defense response (By similarity). Acts as transcriptional activator in vitro.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- BTB/POZ domain and ankyrin repeat-containing protein NPR1
- BTB/POZ domain and ankyrin repeat-containing protein NPR2
- BTB/POZ domain and ankyrin repeat-containing protein NPR3
Sequence:
MVQGEESSWRMAASTHHERAIPLNQALAYGVQAHASPSVAAAPPASFLDFQPAAAAAAYFGELEEALIHGANAGGVVDPGMIRADVHSKSAAAAATAGYLAARPPTLEIFPSWPMRQQQQLHSGNSQSVGSTTDSSSAQNTMPQMELVSPASIRASSEHQHQQQQPGQEVMMVTTDDYSYKPGLAAASPSFQQQHQLQHHQQQQLHGGGDHDKRKHGSTRKDGKSVDAKTERRLAQNREAARKSRLRKKAYVQNLETSRVRLQQIEQELQRARSQGLFLGGCRAAGDMSSGAAMFDMEYARWLDDDSKRLTDLRGGLQAHLLDTNLGLIVEECMQHYDELFQLKAALARSDVFHLLTGTWATPAERCFLWMGGFRPSDLLKILIQQLDPLTEQQMLGIYSLQQSSEQAEEALAQGLQQLHQSLADTVAAGTLNDGPGVPNYMSLMAIALDKLASLESFYQQADNLRQQTLHQLRRILTTRQAARCFLSIGEYYRRLRALSNLWSSRPRENFIGTESVSPTGTELQPMHNQPQQNQYSGF
Protein: Cadherin-related neural recepter 7 (O88194)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
FSSKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPLREQRLLISESKQPDSRFPLEGASDADIGENAVLVYRLSQNEYFSLEPPINSKQTKRPSLILKKVLDREKTPELNLLLTATDGGKPELTGTVQLWVRVLDVNDNDPVFDHLEYKVRIMENAAKETLVITLNATDLDEGANGQLVYSLMSIKPTGRHLFTLDEKNGELRVNGTLDYEENKLYEIEVLATDKGTPPMVGHCVVLVEILDTNDNSPEVTLTSLSLPVREDAQPNTVIALISVSDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRERVSTYDLVVIARDGGSPSLSATVSVSVEVADVNDNAPVFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQYQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLPHGAVGAGGAVSELVSRSVGSGHVVTKVRAVDADSGYNAWLSYEVQLGTGGVRSPFRVGLYTGEISTTRALDEVDSPRQTLLVLVKDHGEPALTATATVLVSLVESGQAPKSFSQASGRASAPEASLVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPMVNEATGGPGKPMLVCSSEVGSWSYSQQRRQRVCSGEVLPKTDLMAFSPSLPPNLGRDERERQESESSHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen) (Q9UBF1)
Organism: Homo sapiens (Human)
Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
Interaction partners:
- Transcription intermediary factor 1-beta
- E3 ubiquitin-protein ligase RBX1
- Sarcoma antigen 1
- Melanoma-associated antigen C1
- Protein SSX1
- P antigen family member 5
- Sperm surface protein Sp17
- Adapter molecule crk
Sequence:
MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASSTLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEEPVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTKVWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE
Protein: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a) (P97797)
Organism: Mus musculus (Mouse)
Function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1 (By similarity). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Leukocyte surface antigen CD47
- Tyrosine-protein phosphatase non-receptor type 11
- Tyrosine-protein phosphatase non-receptor type 6
- Tyrosine-protein kinase SYK
- TYRO protein tyrosine kinase-binding protein
- OX-2 membrane glycoprotein
- Growth factor receptor-bound protein 2
- Macrophage colony-stimulating factor 1 receptor
- Low affinity immunoglobulin gamma Fc region receptor III
- Low affinity immunoglobulin gamma Fc region receptor II
Sequence:
MEPAGPAPGRLGPLLLCLLLSASCFCTGATGKELKVTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGVGPSRLLIYSFAGEYVPRIRNVSDTTKRNNMDFSIRISNVTPADAGIYYCVKFQKGSSEPDTEIQSGGGTEVYVLAKPSPPEVSGPADRGIPDQKVNFTCKSHGFSPRNITLKWFKDGQELHPLETTVNPSGKNVSYNISSTVRVVLNSMDVNSKVICEVAHITLDRSPLRGIANLSNFIRVSPTVKVTQQSPTSMNQVNLTCRAERFYPEDLQLIWLENGNVSRNDTPKNLTKNTDGTYNYTSLFLVNSSAHREDVVFTCQVKHDQQPAITRNHTVLGFAHSSDQGSMQTFPDNNATHNWNVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSSTRLHEPEKNAREITQVQSLIQDTNDINDITYADLNLPKEKKPAPRAPEPNNHTEYASIETGKVPRPEDTLTYADLDMVHLSRAQPAPKPEPSFSEYASVQVQRK
Protein: Adrenergic receptor alpha 2a (R4I4W0)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
DRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVIPFPPLISIEKKSGQQADQGVAGCKINDEKWYIISSSIGSFFAPCLIMILVYMRTYQIAKRRTRVPPNKRAERPEKKQNGLTDKEDLPATAQLNGEKAAGGSGGQEGEVNGIDMEETSSSEHQENNQCKKSERPLKGKTKTKLSQIKPGDSLPRKTEEERNTKGSRWRGRQNREKRFTFVLAVVIGVFVICWFPFFFTYTL