wanglab/gogpt-training-data huggingface dataset:
Protein: Coiled-coil domain-containing protein 180 (Q9P1Z9)
Organism: Homo sapiens (Human)
Interaction partners:
- Tudor domain-containing protein 7
- Cyclin-dependent kinase 17
- Uncharacterized protein CFAP92
Sequence:
MRGGENRPPARVQSSSEELELRHQSLDAFPGRRLPGRGIQPAAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMRIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLRAGFFEHLEKWFDQCSLNTRVTVATKINELDSELELHLHLHQPRAQQIEKDIHNVRAAELLLHQEQLDSHCAGVTETLKKKRLMFCQFQEEQNVRSKNFRLKIYDMEHIFLNATRSQKLVTLSNTLHQELLSYVDVTQVSLRSFRQYLEESLGKLRYSNIEFIKHCRLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGRGAWACGSRGSSEAGAGGAVCSPPVLCSCPGPSSPKGFKRHRCQPENSGKKAVPSASATSAGSFTPHPKPNKMERKYRVLGDKPPPAAEDFKGIILTLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFITNLATFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKWPGIKPTEVTIQNKILLQPTSSISTTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDCTSQIKEAQRWKDSWKQSLHTIQGLYV
Protein: Uncharacterized protein (Q4GYN2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLILSFSVFASTFLFRICALSFFLFFPLFIYLFTYIFKLLPPSLLLLLLLLLVFAVKGYHNMKRRVLRAHANKRRLRILSAEHGLCLDSYNILCDASFLRAVGHAICNNNFSMGGGGGGGTSSGINNNINNNKNNNKNGISEMHEPPVRTLKALMHETFAAAASQTTQSDSEPAEKSKQQKGINLSLYYLPETATALRRMVQREEKNDVEKVTNRGSKGHGKSISSASHAGGGMKKCGLGAVAEALLKGLMCVGYQNRETTSTAEVSSESGGRNEGKAVTQFITEVASGKPHGYSVHGGKNANFFFVATQSHDVRRLLPADSALIRLTTMPTALWIERNGDSFNYEGSGKMNNRDANSSNYNHNKSYGSSGSGDVHNDFHCGGVRVGGHKGLSEADIAFMRHLSANLVPGAEPPLKRARGFDNIKSVTDGIPHVAKGKSQRDAAVTSRSGDSSVSAFVKHSSRRKARGPNPLSVKKKRKREVLRVDVSASQRKKERKE
Protein: NEDD8-specific protease 1 (EC 3.4.22.-) (Deneddylase-1) (Q9LSS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Processes the pre-form of the ubiquitin-like protein NEDD8/RUB1. Has the capacity to discriminate between NEDD8/RUB1 and ubiquitin. Has no SUMO protease activity.
Interaction partners:
- Ubiquitin-NEDD8-like protein RUB1
- NEDD8-like protein RUB3
- F12F1.16 protein
- NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-activating enzyme E1 regulatory subunit AXR1
- Probable NEDD8-conjugating enzyme Ubc12-like
- NEDD8-conjugating enzyme Ubc12
- NEDD8-activating enzyme E1 regulatory subunit AXL
- Cysteine proteinases superfamily protein
- Ubiquitin-like-specific protease ESD4
Sequence:
MGNTSDDDKILSYEDVVLRRSDLDILNGPIFLNDRVIEFYLSFLSTVHSSTTISLIPPSIAFWISNCPDTEYLKDFMKPLNLRDKDLLILPVNDNSNVEVAEGGLHWSLLVYYKEANTFVHHDSYMGVNRWSAKQLFKAVSPFVSNGDASYKECTDTPQQKNGYDCGVFLLATARVICEWFSSGGMKNRDELWFANVKETVPDLVNHLREEILALIKKLMSESVSK
Protein: Organic hydroperoxide resistance transcriptional regulator (Q92MX6)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MKLDNFLCFAIYSANHAFTRVYKPLLDELDLTYPQYLVMVALWEKDDQTVGSLGEKLFLESSTLTPMLKRLEAMGYILRTRDKADERQVRVRLTETGRALREKASRVPIGIADATGMEPAEVARLKREIAALRASLLR
Protein: Ribonuclease H2 subunit B (A0A2R8Y4Y9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTFFGMAAQRQKRGK
Protein: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (G-alpha-8) (P63095)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P63094}; Lipid-anchor {ECO:0000250|UniProtKB:P63094}.
Interaction partners:
Sequence:
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Protein: Small ribosomal subunit protein uS9 (40S ribosomal protein S16) (P62249)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Interaction partners:
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL28
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL37
- Large ribosomal subunit protein eL33
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL20
- Elongation factor 2
Sequence:
MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR
Protein: Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4] (P01015)
Organism: Rattus norvegicus (Rat)
Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Subcellular location: Secreted {ECO:0000305|PubMed:4344907}.
Interaction partners:
- Type-2 angiotensin II receptor
- Type-1 angiotensin II receptor A
- Type-1 angiotensin II receptor B
- Angiotensin-converting enzyme
- Angiotensin-converting enzyme 2
- Renin
- Endothelin-1 receptor
- Protachykinin-1
- B2 bradykinin receptor
- Angiotensin-converting enzyme
Sequence:
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV
Protein: Sterol uptake protein 2 (Q12286)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway. Involved in sterol uptake.
Subcellular location: Nucleus {ECO:0000269|PubMed:15030478}.
Interaction partners:
Sequence:
MKPNNRTCDVITNKDESLPALLLPALNSYTCDDSLLKGQISSNGRYQPFGFSDCSLLPKRLNIQAGQGSMPVSSIQCADHSYSNWQKESEKTKLPKLGCPTEYTEYYKTVSSGETTDSAVVSSIATNRLKRKRQRDGPSCDSCRIKKIKCNATIIIFLQDRNLISSISSNLHYTLSQDDINQFRMKFFRKLPDVMGTYEVIKHLDKIVLFKACTSCSRRNQKNGKCLFSRGFTKSDMNVFPKINSKLKDKSIFEMTVDDYVAAGFQTL
Protein: Histone H2B type 1-H (H2B-clustered histone 9) (h2B-221) (Q64478)
Organism: Mus musculus (Mouse)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H3.1
- Histone H3.2
- Histone H3.3
- Histone H4
- Plasminogen
- E3 ubiquitin-protein ligase BRE1A
- E3 ubiquitin-protein ligase BRE1B
- Histone H2AX
- Histone H2A type 1-F
- Histone H3-like centromeric protein A
Sequence:
MPEPAKSAPAPKKGSKKALTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: Probable protein phosphatase 2C 64 (AtPP2C64) (EC 3.1.3.16) (Q5PNS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dephosphorylates and represses plasma membrane H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), thus influencing negatively plant growth and fitness.
Interaction partners:
- Probable protein phosphatase 2C 5
- E3 ubiquitin-protein ligase APD4
- E3 ubiquitin-protein ligase APD3
- Protein IQ-DOMAIN 3
- E3 ubiquitin-protein ligase APD2
- Receptor protein kinase-like protein At4g34220
- IQ-domain 21
- E3 ubiquitin-protein ligase APD1
- Leucine-rich repeat receptor-like protein kinase PXC2
- IQ-domain 24
Sequence:
MLSGLMNFLNACLWPRSDQQARSASDSGGRQEGLLWFRDSGQHVFGDFSMAVVQANSLLEDQSQLESGSLSSHDSGPFGTFVGVYDGHGGPETSRFINDHMFHHLKRFTAEQQCMSSEVIKKAFQATEEGFLSIVTNQFQTRPQIATVGSCCLVSVICDGKLYVANAGDSRAVLGQVMRVTGEAHATQLSAEHNASIESVRRELQALHPDHPDIVVLKHNVWRVKGIIQVSRSIGDVYLKRSEFNREPLYAKFRLRSPFSKPLLSAEPAITVHTLEPHDQFIICASDGLWEHMSNQEAVDIVQNHPRNGIAKRLVKVALQEAAKKREMRYSDLKKIDRGVRRHFHDDITVIVVFFDTNLVSRGSMLRGPAVSVRGAGVNLPHNTLAPCTTPTQAAAAGAS
Protein: Protein sumv-1 (Suppressor of synthetic multivulva protein 1) (P46582)
Organism: Caenorhabditis elegans
Function: Nuclear factor that influences the activity of genes involved in vulval development.
Subcellular location: Nucleus {ECO:0000269|PubMed:24882710}. Cytoplasm {ECO:0000269|PubMed:24882710}. Cell projection, axon {ECO:0000269|PubMed:24882710}. Note=Expression is restricted to the nucleus in most cells, but it is also expressed in the cytoplasm and neuronal projections in neurons. {ECO:0000269|PubMed:24882710}.
Interaction partners:
- Protein sumv-2
- Dynactin subunit 5
- Actin-related protein 10
- Dynactin subunit 6
- Probable dynactin subunit 2
- ER membrane protein complex subunit 1
- Dynactin subunit 1
- Actin
- F-actin-capping protein subunit beta
- Histone acetyltransferase
Sequence:
MKQTTRPPAQYIVAPGTRFRLVANEYDKNKYGQCNYASYRTLVRCKQIRSKEELAKHGGRCEEHVEFSKTLENNHKKEVMRCHAENDSKMQRRRFDPWIASNEYISDDDDYLQAAQTVPQRLPDVANDDILDNNSLRYAEYYTDKDILNIKMDLVQKDIDDLIEFKELVTSQAQKEHELLGNDEEEDYPTDMAQRRIFKASTKYSRNDYLTLTTIDPVFHQCCVGPDMDDSLVIVHTMHSILDKIDNFEPIDSEKQCNKPALHLSKFCFDHIILDRSQKMFDVCNACGLTAIGGVDPKCSFHIKSSAIAETTSCPCNRCVQPGEHASPKDEKNSITCYLNSSDDDEPTLGNLSRIESMVSPMQQFSNQSNTLTAPLPRRYQGPPAQVLRPPQMGPPPGINQVPYQPKANRTPPMTSQQLHEQQKLKMQEEEMMSQTCASDFRVRPIDASQFGGGKKKQRLPPRRSPSFGTSPNSYQFHQQSQKKMPSIISTAYNSSPGKMNFQGWKNQSTSSATRPLPQPRFPVHAARSQQPKMIPLEQTQDSIEDDIGPSPMFQGPEPSRRGVPYYKNAYRRTELPSRHAQHSPLTPSTSTSSSQLLAPPKSPQPGTSSQTFRSQASRLPIAPHRAIAAGLNPADVGTRPAYRSQMAGQRPGMTPSAQQGSPQLISPPRQGSMMPVAMNQSPQAVRRQTPVPPYRLMGPQRVTTSYTVVRSGSSSSVAGPSRSSVASGSQHTALDTVQHDPRLANINVRTFLSIGNRDLSTLTQDEIDLLMAGNSPEKGGRKAGAPGAKESSKAAGGAQKGTSAASTSVPEPTKSSESSVDPQSDVSFSNPSPAPEVIEKVAPAAMTITSNKRKIDETLASESTSSEATLIHDTTSSSSAETVSGEPPAKKSSDVSAPVPSPEKEKEKIDRPKTPKSSTKRTTPTPSGRTPRAAAIAANQAISHSKPNVPSASTSSSAASTDQENPLDLLAELSVAAAAEEQQQAIGSTSKNGGSTKKTQRKSPSRSSIGKKRENSEEYEEEL
Protein: ilv operon leader peptide (ilvGMEDA operon attenuator peptide) (P62522)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein IlvX
- Uncharacterized protein YifB
- leu operon leader peptide
- ilv operon leader peptide
- trp operon leader peptide
- thr operon leader peptide
Sequence:
MTALLRVISLVVISVVVIIIPPCGAALGRGKA
Protein: Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein) (Q86XT2)
Organism: Homo sapiens (Human)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular location: Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Tumor susceptibility gene 101 protein
- Vacuolar protein sorting-associated protein 28 homolog
- Multivesicular body subunit 12B
- Multivesicular body subunit 12A
- Ubiquitin-associated protein 1
- Vacuolar protein-sorting-associated protein 36
- Vacuolar-sorting protein SNF8
- Vacuolar protein-sorting-associated protein 25
- Charged multivesicular body protein 3
- Charged multivesicular body protein 2a
Sequence:
MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLEREACLASNYALAKENLALRPRLEMGRAALAIKYQELREVAENCADKLQRLEESMHRWSPHCALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSAQPAPTSAADPPKSFPAAAVLPTGAARGPPAVPRSLPPLDSRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR
Protein: Death-associated protein 1 (DAP-1) (P51397)
Organism: Homo sapiens (Human)
Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Interaction partners:
- Death-associated protein kinase 1
Sequence:
MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK
Protein: Baseplate wedge protein gp53 (Gene product 53) (gp53) (P16011)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Baseplate protein that is located next to the tail tube (inner baseplate). Involved in the tail assembly. Involved in the tail assembly.
Subcellular location: Virion {ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:15342608, ECO:0000269|PubMed:2403438, ECO:0000269|PubMed:27193680}. Note=Present in 6 copies in the baseplate. {ECO:0000303|PubMed:21129200}.
Interaction partners:
Sequence:
MLFTFFDPIEYAAKTVNKNAPTIPMTDIFRNYKDYFKRALAGYRLRTYYIKGSPRPEELANAIYGNPQLYWVLLMCNDNYDPYYGWITSQEAAYQASIQKYKNVGGDQIVYHVNENGEKFYNLISYDDNPYVWYDKGDKARKYPQYEGALAAVDTYEAAVLENEKLRQIKIIAKSDINSFMNDLIRIMEKSYGNDK
Protein: Adenine deaminase (ADE) (EC 3.5.4.2) (Adenine aminohydrolase) (AAH) (Q9I6Y4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Interaction partners:
- Probable purine/pyrimidine phosphoribosyl transferase
- Nonspecific ribonucleoside hydrolase
- Xanthine dehydrogenase
- Xanthine dehydrogenase
- Adenine phosphoribosyltransferase
- AMP nucleosidase
- Guanine deaminase
- Guanine deaminase
- 8-oxoguanine deaminase
- Probable hydroxylase molybdopterin-containing subunit
Sequence:
MYEWLNALPKAELHLHLEGTLEPELLFALAERNRIALPWNDVETLRKAYAFNNLQEFLDLYYAGADVLRTEQDFYDLTWAYLQKCKAQNVVHVEPFFDPQTHTDRGIPFEVVLAGIRAALRDGEKLLGIRHGLILSFLRHLSEEQAQKTLDQALPFRDAFIAVGLDSSEVGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKVERIDHGVRAFEDERLMRRLIDEQIPLTVCPLSNTKLCVFDDMSQHTILDMLERGVKVTVNSDDPAYFGGYVTENFHALQQSLGMTEEQARRLAQNSLDARLVK
Protein: Barttin (Q8VIM4)
Organism: Mus musculus (Mouse)
Function: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:11734858}; Multi-pass membrane protein {ECO:0000255}. Note=Staining in membranes of the renal tubule is basolateral. Also detected in basolateral membranes of intercalated cells of the collecting duct, which are known to express CLCNKB as well. Both acid-secreting alpha-intercalated cells and base-secreting beta-intercalated cells express this protein basolaterally, but intervening AQP2-expressing principal cells appear devoid of protein expression. In the inner ear, colocalizes with CLCNK in K(+)-secreting marginal cells of the stria vascularis. The basolateral staining contrasts with the apical localization of the KCNQ1 K(+) channel. Also found in K(+)-secreting vestibular dark cells, where it colocalized in basolateral membranes with CLCNK below apical membranes that expressed KCNQ1.
Interaction partners:
- Chloride channel protein ClC-Ka
- Chloride channel protein ClC-Kb
- Solute carrier family 12 member 1-chloride cotransporter 1)
- ATP-sensitive inward rectifier potassium channel 1
- Solute carrier family 12 member 3
- H
- Chloride channel protein 1
Sequence:
MADEKTFRIGFIVLGLFLLSLGTFLMSHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALSLLETGLSEVKSPQPPYVRLWEEAAYDQSLPDFTHIQMKVMGYSEDPRPLLAPELKTGASSVREGEPRTAQAWMEAPVVVHRGSDENEGEKSHSQSSPSVGPQGSAPLASFHDDLDVGSSEGSSLQPSPNRDEPHRQVPWASRGPLDRFSDFALIDDTPTSEDTVLDGQAREAALPRKQQWSLRMKGETVQARAEEPEQEEEDLYYGLPDSPGNPLPDKELGFEPDIQG
Protein: Contig An02c0220, genomic contig (A2QDL5)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MRATPAVKYPWSKLHLPLPRTPRQSEQLLNAITSSFRRQLDREYPTNNPSTSDRNETSAENSPENPHSSAHATDRLLHNILDNPLFRVAPSASPISSNASGMRDAKQRRMLTEPMVVFDELAAAGHVTKGDLLQCLQYQLMLARGTGDDFVKAMKDSRAGTKVVNWWLASGWRDRLKIFDHRQTSATLVKFMVAEGMQDTVLLWLKMLANTDLRAFNGHISRSLAERVARNLLTDFLAAENQYGGGLASAMRYYVQVGDMYFSMEDLHNRRDTKNLLRHAGKYLFQQVSREVPNDEKMVSATVYEEYARVIATVCTDFVTASVALYHPTVPDPKPFLRYVYNKDMPTLQTWPAGLREVFVRSGSVALRLLMDQGKRGDATWLAGILQHVSDTDKAKVEHEASADEKALLSRLLRVDMAWT
Protein: Protein DETOXIFICATION 52 (AtDTX52) (Multidrug and toxic compound extrusion protein 52) (MATE protein 52) (Protein ABNORMAL SHOOT 3-like 2) (Q4PSF4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a negative regulator of hypocotyl cell elongation in the light.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:26160579}; Multi-pass membrane protein {ECO:0000269|PubMed:26160579}.
Interaction partners:
- Major facilitator superfamily protein
- Major facilitator superfamily protein
- At2g34355
- Protein DETOXIFICATION 42
- Sugar transporter ERD6-like 2
Sequence:
METPNIISHTNLLSKIDLEKQNPAPIFPTITELKSEARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITGYSVLAGLALGMDPLCSQAFGAGRPKLLSLTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAGTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIPSCIGVCLEWWWYEIMTVLCGLLIDPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFYLVGTPVAVGLTFWAAYGFCGLWVGLLAAQICCAAMMLYVVATTDWEKEAIRARKLTCTEGVDVVITTTQTNGDLSEPLIYVVTVATD
Protein: Maturation protein A (MP) (Assembly protein) (A protein) (P03610)
Organism: Escherichia phage MS2 (Bacteriophage MS2)
Function: The maturation protein is required for the typical attachment of the phage to the side of the bacterial pili. Binds to sequences located toward each end of the genome, hence circularizing it. The RNA genome-maturation protein A complex is released from the capsid upon host receptor binding. Maturation protein A enters the cell along with the viral RNA.
Subcellular location: Virion. Note=A single copy of the maturation protein is present in the virion and replaces a coat protein dimer at one of the icosahedral two-fold axes. {ECO:0000269|PubMed:27992877, ECO:0000305|PubMed:23810697}.
Interaction partners:
Sequence:
MRAFSTLDRENETFVPSVRVYADGETEDNSFSLKYRSNWTPGRFNSTGAKTKQWHYPSPYSRGALSVTSIDQGAYKRSGSSWGRPYEEKAGFGFSLDARSCYSLFPVSQNLTYIEVPQNVANRASTEVLQKVTQGNFNLGVALAEARSTASQLATQTIALVKAYTAARRGNWRQALRYLALNEDRKFRSKHVAGRWLELQFGWLPLMSDIQGAYEMLTKVHLQEFLPMRAVRQVGTNIKLDGRLSYPAANFQTTCNISRRIVIWFYINDARLAWLSSLGILNPLGIVWEKVPFSFVVDWLLPVGNMLEGLTAPVGCSYMSGTVTDVITGESIISVDAPYGWTVERQGTAKAQISAMHRGVQSVWPTTGAYVKSPFSMVHTLDALALIRQRLSR
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (Q95T01)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
Sequence:
MQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNHTNIDDAKESTNCL
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (G3XCJ9)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MDDLLQRVRRCEALQQPEWGDPSRLRDVQAYLRGSPALIRAGDILALRATLARVARGEALVVQCGDCAEDMDDHHAENVARKAAVLELLAGALRLAGRRPVIRVGRIAGQYAKPRSKPHEQVGEQTLPVYRGDMVNGREAHAEQRRADPQRILKGYAAARNIMRHLGWDAASGQEANASPVWTSHEMLLLDYELSMLREDEQRRVYLGSTHWPWIGERTRQVDGAHVALLAEVLNPVACKVGPEIGRDQLLALCERLDPRREPGRLTLIARMGAQKVGERLPPLVEAVRAAGHPVIWLSDPMHGNTIVAPCGNKTRLVRSIAEEVAAFRLAVSGSGGVAAGLHLETTPDDVTECVADSSGLHQVSRHYTSLCDPRLNPWQALSAVMAWSGAEAIPSATFPLETVA
Protein: Probable actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) (Q9XWV3)
Organism: Caenorhabditis elegans
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Probable actin-related protein 2/3 complex subunit 4
- Actin-related protein 3
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit
- Probable actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Probable actin-related protein 2/3 complex subunit 5
- CRIB domain-containing protein
- SPIN90/Ldb17 leucine-rich domain-containing protein
- WH1 domain-containing protein
Sequence:
MPAYHSKFDTELKVLPLGNTNMGKLPIRTNFKGPAPQTNQDDIIDEALTYFKPNIFFREFEIKGPADRTMIYLIFYITECLRKLQKSPNKIAGQKDLHALALSHLLPIPGENGFPLNSMYKAPQSKPDEDEMRAYLQQIRQEIGARLCDLAFPDPQDRPSKWWLCFARRRFMDKGLVGQGVNL
Protein: Ornithine decarboxylase (ODC) (EC 4.1.1.17) (Q9UQW9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08432}.
Interaction partners:
- Spermidine synthase
- Ornithine decarboxylase antizyme
- Arginase
- Arginase
- S-adenosylmethionine decarboxylase proenzyme
- Ornithine aminotransferase car2
- Putative agmatinase 2
- Putative agmatinase 1
- Putative agmatinase 3
- Argininosuccinate synthase
Sequence:
MPAIMEKNMLVSESLRTTELLGHVKPIDSVVTWSSPGSSRQAIGEAFKNTIEEIERAAVRGEPADSDAFFVADLNGVYRQLLRWHAKLPRVQPFYAVKCNPDPKVLALLNKFGTGFDCASKGELEQILGLGVSPDRIVYANPCKAITYVRYAASKGINLMTFDNADELYKVKQHHPNSRLLLRISTDDSNSLCRLSLKFGASLDDTGKLLDIAKSLELNVVGVSFHVGSGSYDPSAFLDAIQRSRQVFDQGLERGFNFDLLDIGGGFMNDSFDGVADLIRSALDTYFDPSIRVISEPGRFFVSSSFTLAVNVIAKRKLDDEEKVMYYVNDGVYGSLNCILFDHQHPVARVLKCGSRFVYNDLVGTGQHRCFIWGPTCDSLDVIANDAHLPYELNVGDWIYFEDAGAYTVAAASCFNGFKTSRIVYLDTDILD