wanglab/gogpt-training-data huggingface dataset:
Protein: Beta-glucosidase BoGH3B (EC 3.2.1.21) (Glycosyl hydrolase family protein 3B) (BoGH3B) (A7LXU3)
Organism: Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)
Function: Catalyzes the hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose in xyloglucan degradation, leading to remove the backbone 'G' units.
Subcellular location: Periplasm {ECO:0000305}. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus. {ECO:0000269|PubMed:24463512}.
Interaction partners:
Sequence:
MKNIKKMVLVSAFAGTCLTPHAQTASPVIPTDPAIETHIREWLQKMTLEQKIGQMCEITIDVVSDLETSRKKGFCLSEAMLDTVIGKYKVGSLLNVPLGVAQKKEKWAEAIKQIQEKSMKEIGIPCIYGVDQIHGTTYTLDGTMFPQGINMGATFNRELTRRGAKISAYETKAGCIPWTFAPVVDLGRDPRWARMWENYGEDCYVNAEMGVSAVKGFQGEDPNRIGEYNVAACMKHYMGYGVPVSGKDRTPSSISRSDMREKHFAPFLAAVRQGALSVMVNSGVDNGLPFHANRELLTEWLKEDLNWDGLIVTDWADINNLCTRDHIAATKKEAVKIVINAGIDMSMVPYEVSFCDYLKELVEEGEVSMERIDDAVARVLRLKYRLGLFDHPYWDIKKYDKFGSKEFAAVALQAAEESEVLLKNDGNILPIAKGKKILLTGPNANSMRCLNGGWSYSWQGHVADEYAQAYHTIYEALCEKYGKENIIYEPGVTYASYKNDNWWEENKPETEKPVAAAAQADIIITCIGENSYCETPGNLTDLTLSENQRNLVKALAATGKPIVLVLNQGRPRIINDIVPLAKAVVNIMLPSNYGGDALANLLAGDANFSGKMPFTYPRLINALATYDYKPCENMGQMGGNYNYDSVMDIQWPFGFGLSYTNYKYSNLKVNKPTFNADDELIFTVDVTNTGKVAGKESVLLFSKDLVASSTPDNIRLRNFEKVSLEPGETKTVTLKLKGSDLAFVGYDGKWRLEKGDFKIKCGDQWMDIVCDQTKVWNTPNKNTLHK
Protein: Seripauperin-4 (P53427)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Seripauperin-20
- Seripauperin-14
- Seripauperin-13
- Seripauperin-11
- Seripauperin-2
- Seripauperin-16
- Seripauperin-12
- Seripauperin-18
- Seripauperin-24
- Seripauperin-10
Sequence:
MVKLTSIAAGVAAIAATASATTTIAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISKALSKDGIYTIAN
Protein: Dihydroorotate dehydrogenase (fumarate) (EC 1.3.98.1) (Dihydroorotate oxidase) (Q4QEW7)
Organism: Leishmania major
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU364042}.
Interaction partners:
- Orotidine 5'-phosphate decarboxylase
- Uncharacterized protein
- Putative dihydroorotase
- Acyl-lipid
- Integral membrane protein
- Cytochrome b5 heme-binding domain-containing protein
- aspartate carbamoyltransferase
- Carbamoyl phosphate synthase arginine-specific large chain
- NADH-cytochrome b5 reductase-like protein
- NADH-cytochrome b5 reductase
Sequence:
MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTLDGTAESTR
Protein: 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (A0NXQ7)
Organism: Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata)
Function: Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp, which would allow L.aggregata to grow on t4LHyp as a sole carbon source. Displays no proline racemase activity.
Interaction partners:
Sequence:
MRVIDSHTAGEPTRVVLDGGPDLGSGTLAERAARLEAEHLDFCASVVLEPRGHDAIIGALLVPPSDPACAAGVIYFNNLQNLGMCGHATIGLGVTLAHLGRIRPGRHRFETPVGVVEIDLIDANTVSVVNIESYRLAKDVTVEVEGVGPVTGDVAWGGNWFFLVKNSPIALTGANIRPLTDLTLKIRTALEKAGVTGKDGAWIDHIELFGPAEDPAAQSRNFVLCPGGAYDRSPCGTGCSAKLACLAADGALAPGQDYLQESVIGSTYKISYQPGPGGGVIPTITGQAFVTSDATLIFNPADPYRSGIRL
Protein: Lectin-B (PL-B) (Q9AVB0)
Organism: Phytolacca americana (American pokeweed) (Phytolacca decandra)
Function: N-acetyl-D-glucosamine binding lectin. Has high hemagglutinating activity towards human erythrocytes. Shows potent mitogenic activity towards human peripheral blood lymphocytes.
Interaction partners:
Sequence:
MKRISNSIVGMLVVVLSVMLLLPVEGHEGHGVVELIMGKLGAPECGREASGKVCPDDLCCSVFGHCGVSVQHCGDGCQSQCVTNWRCGKDFDDRTCPKKLLCCSKDGWCGNTDAHCGEGCQSQCEQYNWRCGVDFGNRTCPNDLCCSVGGWCGTTDDHCGEGCQSQCEQYNWHCGVDFGNRTCPNDLCCSEWGWCGITEGYCGEGCQSQCNHQRCGKDFAGRTCLNDLCCSEWGWCGSSEAHCGQGCQSNCDYNRCGRNFGFRTCPNELCCSSGGWCGSNDAHCGKGCQSQCDYWRCGVDFSGRVCPQGRCCSAWGWCGDTEEYCEEGCQSQCKLSSLPSPLSQILAIRKLNATIPTMAVE
Protein: Beta-1,2-xylosyltransferease XAX1 (EC 2.4.2.-) (Protein XYLOSYL ARABINOSYL SUBSTITUTION OF XYLAN 1) (Q6Z7I3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms. Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:23027943}; Single-pass type II membrane protein {ECO:0000305|PubMed:23027943}.
Interaction partners:
Sequence:
MTSTAYSRPSKLPGGGNGSDRRLPPRLMRGLTTKIEPKKLGVGLLAGCCLALLTYVSLAKLFAIYSPVFASTANTSALMQNSPPSSPETGPIPPQETAAGAGNNDSTVDPVDLPEDKSLVEAQPQEPGFPSAESQEPGLPAALSRKEDDAERAAAAAASEIKQSEKKNGVAAGGDTKIKCDENGVDEGFPYARPSVCELYGDVRVSPKQKTIYVVNPSGAGGFDENGEKRLRPYARKDDFLLPGVVEVTIKSVPSEAAAPKCTKQHAVPAVVFSVAGYTDNFFHDMTDAMIPLFLTTAHLKGEVQILITNYKPWWVQKYTPLLRKLSNYDVINFDEDAGVHCFPQGYLGLYRDRDLIISPHPTRNPRNYTMVDYNRFLRDALELRRDRPSVLGEEPGMRPRMLIISRAGTRKLLNLEEVAAAATELGFNVTVAEAGADVPAFAALVNSADVLLAVHGAGLTNQIFLPAEAVVVQIVPWGNMDWMATNFYGQPARDMQLRYVEYYVGEEETSLKHNYSRDHMVFKDPKALHAQGWQTLAATIMKQDVEVNLTRFRPILLQALDRLQQ
Protein: Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (Glutamate binding) (Zgc:136572) (Q1ECY6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSQDKQTYPIMGENNPLHNNVYGPPKTDAFGMPPPNYSQGPGAPPYAAPGTYGPPDYGQPAYGQPPAPGFGPGPGPYPQMPYPQMPYPQANYAQGPYPQSPYQQGPGQPAFGVDPNASMESPGYHGGDGPPSYYGNDDFANSNWEDKSIRRAFIRKVFMVLTVQLLVTFSFVTVFTFAKDAKVFVRRNQWTYYVSYAIFFVSLIVLSCCGEVRRKHPWNLVALSILTLSLSYLVGMIASFYDTDAVIMAVGITVVVCFAVVVFSLQTKYDFTSCYGVLLVCTIVLLVACILCIFIRNKILHIVYASLGALLFTCFLAVDTQLLLGNKKLAISPEEYVFAALNLYTDIINIFLYILAIVGRTRD
Protein: p22 protein (Q584R4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mitochondrial RNA binding complex 1 subunit
Sequence:
MRRALVFTAFAANSAAAAFAASFAKSHTAVVTNPTVPQPVYMQQRLVSDQRLSEATLRELEDERQRAGLPEKPEIPEGWTIDRKPGVTHFTMRKSHGDEEIILQLTGEDRSNEEITRTLDVLVVNGGKALVFGMSVEDGEFVINNVCFRHDGKLALDTSAEAQFQKSQLYMGPDLADLEDHLVDSFTSYLSARGVNDTLANFIDQFSLWSEQADYEEWLSSINKFVS
Protein: Carbamoyl phosphate synthase arginine-specific small chain (CPS) (CPSase) (CPSase-arg) (EC 6.3.5.5) (Arginine-specific carbamoyl phosphate synthetase, glutamine chain) (Carbamoyl phosphate synthase A) (CPS-A) (Glutamine-dependent carbamoyl phosphate synthetase) (P07258)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:200419, ECO:0000269|PubMed:205532}.
Interaction partners:
- Carbamoyl phosphate synthase arginine-specific large chain
- Argininosuccinate synthase
- Ornithine carbamoyltransferase
- Protein ARG5,6
- Glutamine synthetase
- Amidophosphoribosyltransferase
- Glutamate synthase
- Arginine attenuator peptide
- Multifunctional protein URA2
- Putative glutamine--fructose-6-phosphate aminotransferase
Sequence:
MSSAATKATFCIQNGPSFEGISFGANKSVAGETVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSGEARDEYNLLKYFESPHIHVVGIVVAEYAYQYSHWTAVESLAQWCQREGVAAITGVDTRELVQYLREQGSSLGRITLADHDPVPYVNPMKTNLVAQVTTKKPFHVSALPGKAKANVALIDCGVKENIIRCLVKRGANVTVFPYDYRIQDVASEFDGIFLSNGPGNPELCQATISNVRELLNNPVYDCIPIFGICLGHQLLALASGASTHKLKYGNRAHNIPAMDLTTGQCHITSQNHGYAVDPETLPKDQWKPYFVNLNDKSNEGMIHLQRPIFSTQFHPEAKGGPLDTAILFDKFFDNIEKYQLQSQAKSSISLKVTYSTDKSRLQSINVTKLAKERVLF
Protein: Protein ARABIDOPSIS THALIANA ANTHER 7 (AtA7) (Non-specific lipid transfer protein Y.4) (AtLtpY.4) (F4JL89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255}.
Interaction partners:
- Non-specific lipid-transfer protein 12
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- At1g66850
- Beta-glucosidase 20
- Uncharacterized protein At1g68875
- Short-chain dehydrogenase reductase ATA1
- ATA20 protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Non-specific lipid-transfer protein 15
- Protein DETOXIFICATION 6
Sequence:
MKIHAILVVAFLVLMKTAVSQDNNPLEHCRDVFVSFMPCMGFVEGIFQQPSPDCCRGVTHLNNVVKFTSPGSRNRQDSGETERVCLCIEIMGNANHLPFLPAAINNLPLRCSLTLSFPISVDMDCSQFRNTKNPDVEKLN
Protein: ADAM metallopeptidase domain 17 (ADAM metallopeptidase domain 18) (B2RNB2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Protein: Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) (B1AWL2)
Organism: Mus musculus (Mouse)
Function: Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:17353115, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}.
Interaction partners:
Sequence:
MEVLQCDGCDFRAPSYEDLKAHIQDVHTAFLQPTDVAEDNDDEPLSGSMNASNQTEVEFSSIKDEFVIAEDLPGQSATALGSGGYYGHSPGYYGQHITPNPKPTNKFFQCKFCVRYFRSKNLLIEHTRKVHGAQAEESPTGPPVPGSLNYNIMMHEGFGKVFSCQFCTYKSPRRARIIKHQKMYHKNSLKESTAPPPAPAPLPDPLVPPVSLQDPCKELPAEVVERSILESMVKPLTKSRGNFCCEWCSYQTPRRERWCDHMMKKHRSMVKILSSIRQQEGPNVSEAQNDNEPSPTSNSTYLSMNAASREMPNANVSNFRGSMGNSIMRPNSSSTSKFSSSMSYPQMKPKSPHNSGLVNLTERSRYGMSDMTNSSADLDTNSMLNDSSSDEDLNEVDSENGLSVLDHQASGLSAEQLMGSDGNKLLETKGIPFRRFMNRFQCPFCPFLTMHRRSISRHIENIHLSGKTAVYKCDECPFTCKSSLKLGAHKQCHTGTSDWDTVNSQSESLSSSLNEGMVSYESSSINGRKSGVMLDPLQQQQPPQPPPPLPPPPPPPSQPLPQPPPPPLQSPHQVPPPTQQPQPPTQAPPLHPYKCTMCSYSTMTLKGLRVHQQHKHSFCDNLPKFEGQPSSLPLENETDSHPSSSNTVKKSQTSILGLSSKNNFVAKANRKLASDFPLDLSPVKKRTRIDEIASNLQSKINQTKLQEDAIINVEDDEEEEDDNEVEIEVELDREEEATDPIMEVPTAFSAQQIWARDASEAQKEPNYRSITHDYTATNGAEIELTLSEDEEDYYGSSASMKDQVSNAALLNTQPAIYGTEPSNENTDFGDSGRLYYCKHCDFNNKSARSVSTHYQRMHPYIKFSFRYILDPNDHSAVYRCLECYIDYTNFEDLQQHYGEHHPEAMNVLNFDHSDLIYRCRFCSYTSPNVRSLMPHYQRMHPTVKINNAMIFSSYVVEQQEGLNAESQTLREILNSAPKSMATSTPVARGGGLPATFNKNTPPKTFTPECESQKDPSVNTVVVYDCDVCSFASPNMHSVLVHYQKKHPEEKASYFRIQKTMRMVSVDRGSALSQLSFEVGAPMSPKMSNMGSPPPPQPPPPDLSIELYYCKHCSYSNRSVVGVLVHYQKRHPEIKVTAKYIRQAPPTAAMMRGAEGLQDSPRPPAPLQLNSSERDCPPVETEMFFCQHCDYGNRTVKGVLIHYQKKHRDFKANADVIRQHTATIRSLCDRNQKPASCVLLPASGMERDKTKLRALKCRQCSYTSPYFYALRKHIKKDHPALKATVTSIMRWAFLDGLIEAGYHCEWCIYSHMEPSGLLLHYQRRHPEHYVDYTYMATKLWAGPDPSSPTLTMSAEAKTYRCRDCVFEAVSIWDITNHYQAFHPWAMNGDESVLLDIIKEKDGVDKALLAPEELIGPVNCENSIPNPLPEQEAECPEDARLSPEKSIHLASANPAISSTPYQCTVCQSEYNNLHGLLTHYGKKHPGMKVKAADFAQDIDINPGAVYKCRHCPYINTRIHGVLTHYQKRHPAIKVTAEDFVHDVEQSADISQNDVEETSRIFKQGYGAYRCKLCPYTHGTLEKLKIHYEKYHNQPEFDVFSPPPPKLPVSLEPEITTEVSPSQVSVTEEEVGEDPMSTAHFSTSHLVSHTVFRCQLCKYFCSTRKGIARHYRIKHNNVRAQPEGKNNLFKCALCAYTNPIRKGLAAHYQKRHDIDAYYTHCLAASRTISDKPNKVIIPSPPKDDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVSHYMKRHPGVFPKKQHASKLGGYFTAVYADEHEKPPLMEEEERSSFERAEVEGEAQDIEWLPFRCIKCFKLSFSTAELLCMHYTDHHSRDLKRDFVILGSGPRFQNSTFQCKHCDSKLQSIAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGSVPAVSAAVKGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHAHPSSQKATPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNKSRVSPVPPSGTAAGTEQKAEAVLHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNMIDHIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNELKPYKCQLCYYETKHTEELDTHLRDEHKVSRNFELVGRVNLDQLEQMKEKIESSSSEDEDKDDEMSSKAEDRELMRFADRGPGVNTEKRFPCEFCGRAFSQGSEWERHVLRHGMSLHDTNQVSRNEIHTKEMVEESMQLPSIEAKEDDEPIGIDFPLKSETVTICVVAADKSLLEDAEAKNE
Protein: Protein NDRG2 (F1R8D1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU367129}.
Interaction partners:
- Family with sequence similarity 49 member A.
- Protein MIX23
Sequence:
MVLEDSESSVFELDITEDDVETSFGRVHCTMKGVPKGNRPTILTFHDIGLNHKSCFESMFHHKDMHEILQHFAVCHVDAPGQQEGASTLSTDYTYPSMDQLSESLPMVLNHFGLKSVIGMGVGAGANILARFALKHPDMVEGLVLINMSTQAEGFMDWAAQKITSWTHALPDTVISHLFGKEEIHNNHELIATFRQLITNNINQSNLQQFVKSYKSRKDLEIERPVQGGNVNTKTLQCPALLIVGDNSPAVDAVVDSNSRMNPTTTTFLKMADCGGLPQVDQPGKLIEAFKYFIQGMGYMPSASMTRLARSRTASNSSNRTRSGTTDEQRGRSHTDVSMESACVEHSSSGHSVSVELTC
Protein: Mesogenin-1 (MesP-related bHLH factor) (Paraxial mesoderm-specific expression and regulatory capacities) (pMesogenin1) (pMsgn1) (Q90ZL1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- T-box transcription factor 16.
- T-box transcription factor TBX6
- T-box transcription factor TBX6L
- T-box transcription factor T-A
- T-box transcription factor Tb.
Sequence:
MAQIDVDVFTAKVLSHWDWSREDRSFGDSASSPESESFDSACSSPDARSSPTAGCEHAEQQKPKVKMSMRRRMKASEREKLRMRSLAEALHQLRDYLPPGYSRRGQPLTKIQTLKYTIQYIKELSGILEQQ
Protein: Insulin-like growth factor 2 mRNA-binding protein 3-A (IGF2 mRNA-binding protein 3-A) (IMP-3-A) (69 kDa RNA-binding protein A) (IGF-II mRNA-binding protein 3-A) (KH domain-containing transcription factor B3-A) (RNA-binding protein Vera-A) (Trans-acting factor B3-A) (VICKZ family member 3-A) (VLE-binding protein A) (Vg1 RNA-binding protein A) (Vg1 RBP-A) (Vg1 localization element binding protein A) (VgLE-binding and ER association protein A) (O73932)
Organism: Xenopus laevis (African clawed frog)
Function: RNA-binding protein that acts as a regulator of mRNA transport and localization. Binds to the RNA sequence motif 5'-UUCAC-3'. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Mediates the specific association of Vg1 RNA to microtubules. Binds specifically to the vegetal localization elements (VLE or VgLE) in the 3'-UTR of Vg1 and VegT mRNAs. Binds to the Vg1 and VegT mRNAs in both the nucleus and the cytoplasm. May regulate mRNA translation (By similarity). Acts as a transcription regulator (By similarity). Binds to the 5'-[TA]GGTTACT-3' motif within element 3 of the TFIIIA gene promoter (By similarity).
Subcellular location: Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Accumulates along the vegetal cortex in oocytes as oogenesis progresses ('late pathway' for RNA localization). Colocalizes with Vg1 RNA along the vegetal cortex.
Interaction partners:
Sequence:
MNKLYIGNLSENVSPTDLESLFKESKIPFTGQFLVKSGYAFVDCPDETWAMKAIDTLSGKVELHGKVIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTESETAVVNVTYANKEHARQGLEKLNGYQLENYSLKVTYIPDEMATPQAPSQQLQQQPQQQHPQGRRGFGQRGPARQGSPGAAARPKPQTEVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPITIHSTPEGCSAACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIEPCAKAEEEIMKKIRESYENDIAAMNLQAHLIPGLNLNALGLFPSSSSGMPPPSVGVPSPTSSTSYPPFGQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDEVVVKITGHFYASQLAQRKIQEILAQVRRQQQQQQKTVQSGQPQPRRK
Protein: Trinucleotide repeat containing adaptor 6C (D3ZRA6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Protein argonaute-1
- Protein argonaute-2
- Protein argonaute-3
- Protein argonaute-4
- GRB10 interacting GYF protein 1
- CCR4-NOT transcription complex subunit 1
- Polyadenylate-binding protein 1
- RNA helicase
- RNA polymerase-associated protein LEO1
- PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Sequence:
MEEKKKKKQEDKKKKEGAQKKAADQKTKVPELTKTCSSQPQPAGTSPSTSTSTISSGSNGKRASACGQQPAASRYLPREVPPRFRQQEQKQLLKRGQPLPTGSLTSVSPAQAAGPAGASPPPLPGAGAQQHPSKLQPDLGHSGLAGHYENCHWGQHPSYRSEADCSWDKVIIDRTDQELWPSTPVTETESASECPTDTDSASNCGSENSSMATGSTQSSFPGHPKKTNGSHGTNGTLVQSPSNPSALGAGAANGNGGMARVWGVATGSSSGLAHCSVGGGDGKMDNMIGDGRSQNCWGASNSNAGINLSLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQSMGSQNGNPVGTLGAWGNLLPQESTEPQTSTSQNVSFSVQPQNLNTDGPNNTNPLNNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQGSGSGGEGMGSSVWGLSPGNPATGSTNCGFSQGNGGDTVNSALSAKQNGSSSAAQKEGNGGNAWDSGPPAGPGILAWGRGNGNGIGNIHSGAWGHPSRSSSNGVNGEWAKPPNQHSSSDINGKGSTGWDSASAASQTPALQPGSEHMNSWAKATSSGTTASEGSSEGSGSHNEGSTGREGAGEGRRRDKGVLDQGHIQLPRNDLDPRVLSNSGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGSVATQPSNSGGKTDGSIMNSTNTSSVSGWVSSPPAAVPANTSWGDSNNKAPSGPGVWGDSISSTAVNNAAATKSGHAWSGTVNQEDKSPTWGEPQKPKSQNWGDGQRANPAWSAGAGDWADSPSVLGHLGDGKKSGSGWDADGSRSGSGWNDATRCGTSGWASGTNAKVNPGTNWGESLKPGPQQNWAHKPQDNNVSNWGGAASVKQTGTGWIGGPLPVKQKDSSEATGWEEPSPPSIRRKMEVDDGTSAWGDPSTYNNKTVNMWDRNNPVIQSSTTAPATPTTPTLSSTTHRAETPPSHQAGTQLNRSPLLGPVSSGWGEMPNVHSKAENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWDHPAEPVVPFGRASAPAAATALCKPASKSMQEGWGSGADEMNLGTSQWEDEDGDMWNNAASQESSSSCSSWGNASKKGLQKGMKTPGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNSMNLDQAMSALLEKKVDMDKRGLGMTDYNGMVTKPLGCRPPISKESSMDRPTFLDKLTLSFSNQDGGLVEEPTTSPFLPSPSLKLPLSNSALPNQALGGIASGLGMQNLNSSRQIPSGNLGVFGNSGAAQARTMQQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLSPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKPGMDSFPPHPQAPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSIDMSSGLSVKDPSQSQSRLPQWTHPNSMGNLSSAASPLDQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSISWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGKLSDIKSTWSSGPASHTQASLSHELWKVPRNTTAPTRPPPGLANPKPSSTWGTSPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSGGSQPRLGTSGSTHGLVRSDTAHWNTPCLSGKGSSELLWGGVPQYSSSLWGPPSADDTRVIGSPTPLNTLLPGDLLSGESI
Protein: Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34) (Q5U4F6)
Organism: Mus musculus (Mouse)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96EX3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24183451}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:24183451}. Cell projection, cilium {ECO:0000269|PubMed:28379358}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96EX3}. Cell projection, filopodium {ECO:0000269|PubMed:28379358}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining. {ECO:0000269|PubMed:24183451}.
Interaction partners:
- Cytoplasmic dynein 2 intermediate chain 1
- Cytoplasmic dynein 2 heavy chain 1
- Cytoplasmic dynein 2 light intermediate chain 1
- Dynein light chain roadblock-type 1
- Dynein light chain Tctex-type protein 2B
- Dynein light chain roadblock-type 2
- Dynein light chain 2, cytoplasmic
- Dynein light chain 1, cytoplasmic
- Dynein light chain
- Dynein light chain Tctex-type 1
Sequence:
MAMCASPRPFRRVGSAGAAALAAGGAGGAERRGRPAPLQDETLGVASVPSQWRSVQGIRGETKSCQTAGIATAESSAQARTHADAQVQTEAPEEPAAMAPVSQYDTLRLEAFLRRVEAMVIRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLVYPLAQGQGLHVTGISWNSTGSVLACAYGRLDDGDWSTLKSYVCTWNLDRQGLNPQQPSVVVEVPSAVMCLAFHPTQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGKVLLWRGSGAGQLRLTKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLASEVAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGMVKVWQLSTAFTEQGPREVEDLDQLEAEITT
Protein: Serine/threonine-protein kinase plk-2 (EC 2.7.11.21) (Polo-like kinase 2) (Q9N2L7)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Promotes the localization of brc-1 to the short arm of homologous chromosomes during meiotic prophase I. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor-mediated sensitivity to nicotine but not levamisole. Regulates motility.
Subcellular location: Nucleus {ECO:0000269|PubMed:22018921, ECO:0000269|PubMed:22018922, ECO:0000269|PubMed:30383754}. Cytoplasm {ECO:0000269|PubMed:18199581}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22018922}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:22018922}. Chromosome {ECO:0000269|PubMed:22018921, ECO:0000269|PubMed:22018922}. Note=During meiosis I, localizes to chromosome pairing centers formed at the nuclear envelope in early pachytene and then to the synaptonemal complex in mid and late pachytene (PubMed:22018921, PubMed:22018922). Co-localizes at pairing centers with him-8, zim-3, zyg-12 and sun-1 and partially with plk-1 in early prophase (PubMed:22018921, PubMed:22018922). Co-localizes with syp-1 in synapsed chromosomes at pachytene (PubMed:22018921). Co-localizes with brc-1 in pachytene nuclei (PubMed:30383754). Localizes asymmetrically in the 1-cell embryo which results in higher levels in the somatic cell AB than in the germline blastomere P1 (PubMed:18199581). {ECO:0000269|PubMed:18199581, ECO:0000269|PubMed:22018921, ECO:0000269|PubMed:22018922, ECO:0000269|PubMed:30383754}.
Interaction partners:
- Cyclin N-terminal domain-containing protein
- Sun domain-containing protein 1
- G2/mitotic-specific cyclin-B
- Separin homolog sep-1
- separase
- Kinesin-like protein
- Protein aurora borealis
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3
- Tyrosine-protein phosphatase cdc-14
- Structural maintenance of chromosomes protein 3
Sequence:
MQRVQPSAARVKSQKKEKAPPDVPDVILDGERKTRYEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPFESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFFKSGFMPARLPVSCLTMVPHLNDDEYAEENVSPSGTIDQRGPHQAGRSGLSAIPAHLVSRNSERQQTHRMEAYRQPTDCYLSNLLAQVNDLLATPTADIDDAEAALDSYQSPEALPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSRIMLDTAGTQLTYIEKTEKEHYFDMESAIPSGLQKKMTLLKYFRSYMNDHLLQAGQQVTRKVGDDLARLPTLRVWFRTKSAIVLHLSNGTVQINFFNDHIKMVLCPLMQAVTFIDENKRMFTYKFSHLAENGCPEKFLHRIQYAKCMIQRLVEEHTKEETKHNAPAANAVRLPSTSSNVRLESAADIQPAYPSSSRR
Protein: Glutaminyl-tRNA synthetase 1 (H7C0R3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
QWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLLVFNRTVTLKEDPGKV