wanglab/gogpt-training-data huggingface dataset:
Protein: Type II secretion system protein H (General secretion pathway protein H) (G3XCZ0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377}.
Interaction partners:
- Type 4 fimbrial biogenesis protein PilW
- Type 4 fimbrial biogenesis protein PilV
- Type IV pilus biogenesis factor PilY1
- Type IV pilus non-core minor pilin PilE
- Type 4 fimbrial biogenesis protein PilX
- Type 4 fimbrial biogenesis protein PilY2
- Type IV pilus inner membrane component PilO
- Type IV pilus inner membrane component PilM
- Type IV pilus inner membrane component PilN
- Fimbrial assembly protein PilQ
Sequence:
MSYRSNSTGFTLIELLIIVVLLAIMASFAIPNFKQLTERNELQSAAEELNAMLQYARSEAVSQRRAISIQALKDKDWGKGLSIGVLASGSIAAPLRKHDGFRAATLTAKEKSAVEHLTFTANGTLVPPTERTFAICQNGKTDGGRVLSISQAGRIQLEPSSKAPQSCY
Protein: 15-cis-phytoene desaturase, chloroplastic/chromoplastic (EC 1.3.5.5) (Phytoene dehydrogenase) (Phytoene desaturase) (Q07356)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene with a concomitant isomerization of two neighboring double bonds at the C9 and C9' positions from trans to cis.
Subcellular location: Plastid, chloroplast {ECO:0000250|UniProtKB:Q40406}. Plastid, chromoplast {ECO:0000250|UniProtKB:Q40406}. Membrane {ECO:0000250|UniProtKB:A2XDA1}; Peripheral membrane protein {ECO:0000250|UniProtKB:A2XDA1}.
Interaction partners:
- 15-cis-zeta-carotene isomerase, chloroplastic
- Phytoene synthase 1, chloroplastic
- Lycopene beta cyclase, chloroplastic
- Prolycopene isomerase, chloroplastic
- Lycopene epsilon cyclase, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- Violaxanthin de-epoxidase, chloroplastic
Sequence:
MVVFGNVSAANLPYQNGFLEALSSGGCELMGHSFRVPTSQALKTRTRRRSTAGPLQVVCVDIPRPELENTVNFLEAASLSASFRSAPRPAKPLKVVIAGAGLAGLSTAKYLADAGHKPLLLEARDVLGGKIAAWKDEDGDWYETGLHIFFGAYPNVQNLFGELGINDRLQWKEHSMIFAMPSKPGEFSRFDFPDVLPAPLNGIWAILRNNEMLTWPEKIKFAIGLLPAMVGGQAYVEAQDGLSVKEWMEKQGVPERVTDEVFIAMSKALNFINPDELSMQCILIALNRFLQEKHGSKMAFLDGNPPERLCMPVVDHIRSLGGEVQLNSRIKKIELNDDGTVKSFLLTNGSTVEGDAYVFAAPVDILKLLLPDPWKEIPYFKKLDKLVGVPVINVHIWFDRKLKNTYDHLLFSRSNLLSVYADMSLTCKEYYDPNRSMLELVFAPAEEWISRTDSDIIDATMKELEKLFPDEISADQSKAKILKYHVVKTPRSVYKTIPNCEPCRPLQRSPIEGFYLAGDYTKQKYLASMEGAVLSGKFCSQSIVQDYELLAASGPRKLSEATVSSS
Protein: Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2) (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37) (Q99M15)
Organism: Mus musculus (Mouse)
Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton.
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein.
Interaction partners:
- Intersectin-2
- Tyrosine-protein phosphatase non-receptor type 12
- Phosphatidate phosphatase LPIN2
Sequence:
MTGSLFKGNFWSTDILSTIGYDSIIQHLNNGRKNCKEFEDFLKERASIEEKYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQTLREEARKMEEFREKQKLQRKKTETIMDAAHKQRNAQFKKAMDAKKNYEQKCRDKDEAEQAVHRSANVANQRQQEKLFVKLATSKTAVEDSDKAYMLHINMLEKVREDWQSEHIKACEVFEAQECERINFFRNALWLHLNQLSQQCVANDEMYEQVRKSLETCSIEKDIQYFVNQRKTGQTPPAPIMYENFYSPQRNAAPPGKTTGPNPARRGPLPVPKRIPDDPDYSVVEDYSLLYQ
Protein: Acyl-lipid (7-3)-desaturase (EC 1.14.19.31) (Acyl-lipid 4-desaturase) (Delta-4 fatty acid desaturase) (Q6WNG7)
Organism: Euglena gracilis
Function: Fatty acid desaturase that introduces a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta(7) double bond, resulting in the production of delta-4 desaturated fatty acid docosahexanoic acid (DHA). Also acts on the 16-carbon polyunsaturated fatty acids.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLVLFGNFYVKQYSQKNGKPENGATPENGAKPQPCENGTVEKRENDTANVRPTRPAGPPPATYYDSLAVSGQGKERLFTTDEVRRHILPTDGWLTCHEGVYDVTDFLAKHPGGGVITLGLGRDCTILIESYHPAGRPDKVMEKYRIGTLQDPKTFYAWGESDFYPELKRRALARLKEAGQARRGGLGVKALLVLTLFFVSWYMWVAHKSFLWAAVWGFAGSHVGLSIQHDGNHGAFSRNTLVNRLAGWGMDLIGASSTVWEYQHVIGHHQYTNLVSDTLFSLPENDPDVFSSYPLMRMHPDTAWQPHHRFQHLFAFPLFALMTISKVLTSDFAVCLSMKKGSIDCSSRLVPLEGQLLFWGAKLANFLLQIVLPCYLHGTAMGLALFSVAHLVSGEYLAICFIINHISESCEFMNTSFQTAARRTEMLQAAHQAAEAKKVKPTPPPNDWAVTQVQCCVNWRSGGVLANHLSGGLNHQIEHHLFPSISHANYPTIAPVVKEVCEEYGLPYKNYVTFWDAVCGMVQHLRLMGAPPVPTNGDKKS
Protein: Bifunctional adenosylcobalamin biosynthesis protein CobU (Adenosylcobinamide kinase) (EC 2.7.1.156) (Adenosylcobinamide-phosphate guanylyltransferase) (EC 2.7.7.62) (P0AE76)
Organism: Escherichia coli (strain K12)
Function: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
Interaction partners:
- Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
- Adenosylcobinamide-GDP ribazoletransferase
- Corrinoid adenosyltransferase
- Adenosylcobalamin/alpha-ribazole phosphatase
- Siroheme synthase
Sequence:
MMILVTGGARSGKSRHAEALIGDSSQVLYIATSQILDDEMAARIEHHRQGRPEHWRTVERWQHLDELIHADINPNEVVLLECVTTMVTNLLFDYGGDKDPDEWDYQAMEQAINAEIQSLIAACQRCPAKVVLVTNEVGMGIVPESRLARHFRDIAGRVNQQLAAAANEVWLVVSGIGVKIK
Protein: Interleukin-33 (IL-33) [Cleaved into: Interleukin-33(102-266); Interleukin-33(109-266)] (Q8BVZ5)
Organism: Mus musculus (Mouse)
Function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
Subcellular location: Nucleus {ECO:0000269|PubMed:34644537}. Chromosome {ECO:0000250|UniProtKB:O95760}. Cytoplasm {ECO:0000250|UniProtKB:O95760}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:O95760}. Secreted {ECO:0000269|PubMed:35749514, ECO:0000269|PubMed:35794369}. Note=Secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore following cleavage by CELA1 (PubMed:35749514, PubMed:35794369). Associates with heterochromatin and mitotic chromosomes (By similarity). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). {ECO:0000250|UniProtKB:O95760, ECO:0000269|PubMed:35749514, ECO:0000269|PubMed:35794369}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29045903}. Note=(Microbial infection) Upon infection with H.polygyrus, tethered to the nucleus by the H.polygyrus parasitic protein ARI. {ECO:0000269|PubMed:29045903}.
Interaction partners:
- Interleukin-1 receptor-like 1
- Interleukin-1 receptor accessory protein
- Caspase-1
- Interleukin-1 receptor type 1
- Cytokine receptor-like factor 2
- Somatostatin receptor type 2
- Myeloid differentiation primary response protein MyD88
- Interleukin-17 receptor B
- Thymic stromal lymphopoietin
- Interleukin-13
Sequence:
MRPRMKYSNSKISPAKFSSTAGEALVPPCKIRRSQQKTKEFCHVYCMRLRSGLTIRKETSYFRKEPTKRYSLKSGTKHEENFSAYPRDSRKRSLLGSIQAFAASVDTLSIQGTSLLTQSPASLSTYNDQSVSFVLENGCYVINVDDSGKDQEQDQVLLRYYESPCPASQSGDGVDGKKLMVNMSPIKDTDIWLHANDKDYSVELQRGDVSPPEQAFFVLHKKSSDFVSFECKNLPGTYIGVKDNQLALVEEKDESCNNIMFKLSKI
Protein: COP9 signalosome complex subunit 7 (Q9UUJ7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
Interaction partners:
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 3
- Eukaryotic translation initiation factor 3 subunit H
- COP9 signalosome complex subunit 2
- Cullin-4
- Ubiquitin-like protein 1
- UPF0649 protein C1442.02
- Eukaryotic translation initiation factor 3 subunit F
Sequence:
MEEKISQAIDDPNVFCFQELWIECQEVQKSQPIDSAVLRTLEIFCRGDIRDASSEWNELRFKKLRLLTLIDLANRHVGSSVSFETILVHLQLDRLPPSDPTFTVEYYIMQAMMNQILVGKINAKTQTLHVSWALERFLDSKRIDEMKYSLDRFIERCSNILFQLDAGTPSVSKSFKRASRMSSSDGIDYMVFDKRPRPDDTDFDL
Protein: GTPase (Q5ANA9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Tsc2p
- Serine/threonine-protein kinase TOR
- GTP-binding protein
- Rga2p
- Ubiquitin-binding TORC1 subunit
- Serine--tRNA ligase, cytoplasmic
- Target of rapamycin complex subunit LST8
- GTP-binding protein
- Uncharacterized protein
- Heat shock protein 90 homolog
Sequence:
MSVKARKIAVVGSRSVGKSSITVRFVEDHFVESYYPTIENQFSKSIKFNNQDYAIEILDTAGQDEFSLMNEKHLIGIHGYLLIYSVTSQQSFETVEFIRDKILNSIGNESIPMVLVGNKNDLTYQRQVETTQGQELAKKFNCKFLETSVRENINVEKAFETLIDEIEKIQNPPIQKQQEKCIIM
Protein: Otoferlin b (Otoferlin-like isoform X1) (F8W4A8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Vesicular glutamate transporter 3
- CD164 sialomucin-like 2.
- small monomeric GTPase
- Synaptotagmin
- Myosin VIb
- Novel protein similar to vertebrate synaptotagmin I
- C-terminal-binding protein 2a.
- Parvalbumin
- Transmembrane channel-like protein 2-A
- Guided entry of tail-anchored proteins factor 1
Sequence:
MKRNKHRSSKDDGKGQDEPAILETEDMRMPDPDTISLASVTAVTTNVSNKRSKPDIKIEPSAGRPMDFQVSVTVIEARQLVGLNMDPVVCVEIGDDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKVSVIHSKNLLRSGTLVGSFKLDVGTIYTQPDHQFFHKWATLCDPEDITAGLKGYVKCDIAVVAKGDTIKTPHKANENDEDDIESNLLLPEDVPAERQWARFYLKIYRAEGLPKMNTSIMANVKKAFIGENKDLVDPYVQVLFAGQKGKTSIQKSSYEPIWNEQIVFTEQFPPLCRRMKLQIRDSDKVNDVAIGTHFIDLRKIANDGDKGFLPTLGPAWVNMYGSTRSYTLMDEYQDLNEGLGEGVSFRARLLISLAVEILDTSSPEVMSSTEVQVEGIPNISDNATGKVEEFFLFGSFLEATMIDRKIGDKPINFEVTIGNYGSELDTPTKPKSKKKKGDGDDEESELIHGSSDEEVDDGGDVTSVSTTPPMKPVITDRNYFHLPYFERKPCIYIYSWWQDQRRRLYNANVLDKMADKLEEGLNDVQEIIKTEKAYPERRLRGVLEELSNSCSTFVSLANNDQNQAGRTKLDKERVKLCMQEVESMGQQAKTMRSQVKKSNVKDRIKLAQNFLHKLRFLSDEPQHSVPDIYIWMISNNKRIAYARVPSKDILYSSVEEECGKDCGKVQTIFFKLPGKKSFGPAGWTVQAKTELYLWLGLNRQRKDYLCGLPNGFEENKAVKGPGVQSSPPISLMYTMKQIFQLRVHMYQARSLFAADSTGLSDPFARIFFSTHSQVTEVLNETLCPTWDQLLVFDHVELYGEAGELRDDPPIIVIEIYDQDTVGKADFMGRTFAKPITKMSDEHYGPPRFPPQLEYYQIYRGNCTAGEMLAAFELLQIGPGGKADLPPIDGPTDIDRGPILPVPIGIRPVLSKYRIEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTTLRKFIYRPADKSVNNWSAMEEVVIHTEPEPAVKKIETVVKLDSASDAVVKVDMPDDEKGGKGKKKRKKGEEVEEEELDESMLDWWSKYFASIETLKEAMKAQEAEAEEKEDFESGDGKKKRGKKSKTIPGEAVPEKKKQKIEEFKVYNRELEYEYNQFEDWLHTFNLHRGKCSDDADVDQNAADEDRLIGKFKGSLCIYKVSSDDMSRDMGFDSNMGMFQNIPHNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKSEIKDKENYISKQLNPVFGKSFDVEATLPMDSTLTVSIYDWDLVGTDDLIGETKIDLENRFYSKHRATCGISSTYAIHGYNVWRDPLKPSHILAKLCKDGKIDAPQYGPGGRVKVTNRVYTGPTEVEDENGLKKQTDEHLALAVLNHWEDIPRIGCKLVPEHMETRPLLNPDKPGIEQGRIEMWVDMFPKDMSAPGPALDISPRKPKKFELRVIVWNTDEVVLEDDDIFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLQAEEKIVISKKESMFSWDETEYKIPARLNLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMVTNENEMPMVNIFKQKRIKGWWPFVARDENDELEITGKVEAELQLLTGEEAEKSPVGEGRNEPEPLEKPNRPDTAFLWFMMPLKAIRHLVCNQYKWLVIKIVVALLLLAMLGLFLYSMPGYMVKKLLGA
Protein: Uncharacterized protein (Q381G9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRLYRMCIVVILFGLGWEKLLTPEPLSLVLPENYSQEGLSGLYGSGRNLNHTETRMLYSSIVYNLKNDTDGAFAILAAADRAMLCSAIRWQIRLYARSRDGSYFVPWVTDVVLQLRDAYVHSFKYIIQSIVSDITDSVSGGVSFRRTLLVVKQMRVCFFSPVNSTGCPSYSFLRNVREKTDADIIASCATTDPSYNTHL
Protein: Effector SCP41 (Cysteine-containing protein 41) (VdSCP41) (G2XDH0)
Organism: Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
Function: Effector that binds transcription regulators in the host plant to suppress the host's innate immune response. Inhibits the host plant transcription regulators CBP60G and SARD1.
Subcellular location: Secreted {ECO:0000269|PubMed:29757140}. Host nucleus {ECO:0000269|PubMed:29757140}.
Interaction partners:
Sequence:
MRTETASLLLLAALSVAEELTPNDVPLACANMCGPIVELSYKCDVDGTDELRKLKRRKLFSPQQQQQQQQQQQQSAPKAKRQADPEPQAPAPVPSSTNNQQAADVIFIPGSIGKFKTIPTPLPPADTGVPSMAVTPAAPAPTLPVLDLRPTTTPTNLNPNLPILATPILPSVPASTPLATASSTQVPLPVGNEADAGDGVDAGPAPSNSLNGNVGDMVDDAGNLWPGQKGRQAASDLETACICSNTSFNVRRVAGLCGDCLEQVSGDQGPMRAILASCNFTTERYEPEKESLVANVRVEATKPSFTQTAAASYSWRVSGPTWAVVVGAGMLLGMGW
Protein: Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) (Q9BW66)
Organism: Homo sapiens (Human)
Function: Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Promotes maturation of pre-60S ribosome together with SPATA5, SPATA5L1 and C1orf109.
Subcellular location: Nucleus {ECO:0000269|PubMed:19889979}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. {ECO:0000269|PubMed:19889979}.
Interaction partners:
- AFG2-interacting ribosome maturation factor
- FACT complex subunit SPT16
- ATPase family gene 2 protein homolog A
- ATR-interacting protein
- ATPase family gene 2 protein homolog B
- RNA polymerase-associated protein RTF1 homolog
- 182 kDa tankyrase-1-binding protein
- FACT complex subunit SSRP1
- RNA polymerase-associated protein LEO1
- Protein CUSTOS
Sequence:
MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAGFTTANNIANLKISLLNKDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGLTKIQVKMEKLSSTTKGICELENYHYGEESKRPPLFHTWPTTHFYEVSHKLLEMYRKELLLKRTVAKELAHTGDPDLTLSYLSMWLHQPYVESDSRLHLESMLLETGHRAL
Protein: RNA-binding protein, putative (Q8IL17)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MTDIQIQNQTSNFNTSKKEFENRFDDKALRNLCVKNIPKETKENELLEIFQPFGLIESIKLKVNKNVGPYAIYAHVLFSTPEEAKRCLKQMNGKILNGRALRIDYKRKKNPGDNPENINFNNYNNNKFHRKINRTNQFHNNRYNNNKRNIRNTNDGLMNDDMNSQYDSENSNLIDYEQMNKRPRIGNMNDMKSGNINSTIELNKLIKDYSEKKMLNQLPNDNTTNEAEQIIQTLLNNMMNNKPARIKLYLCDHLRTCAKHVFNRPSIYISNNNGMENSTNQNMYQNNNNNNNNSNGESLLYNSSDKINNNDISLNNQDIFSLPQEKSIHNNKPNVSTNNNEYIWKGILSMKNKENLNIIGHALQGNVNIFLNAHITNIVISHRKRMKSIPQMEAIYYFEIENKQDENIFDSYKNYFNTKDRVGLVSTNENWHLYIIFPGSPIFNQFCNNNNLDNIFIGIVCYNPQIVDKRSALSFAGQNMDASNNYNQGDISGNNNIMKGGQDLYNNPNNTSFQMNSLNFNEKQNNNNNNNFNIGEMSNFNNQNKNHANSEYEQNIREEKNSTYKPMDDNTKEENKSDVPNWLNQFSSLAAYLVKK
Protein: Cytochrome b5 (P00173)
Organism: Rattus norvegicus (Rat)
Function: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-6 double bond introduction during the C-6 desaturation.
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.
Interaction partners:
- NADH-cytochrome b5 reductase 3
- NADPH--cytochrome P450 reductase
- NADH-cytochrome b5 reductase-like
- NADH-cytochrome b5 reductase 1
- NADH-cytochrome b5 reductase 2
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cytochrome P450 2B1
- Cytochrome P450 2E1
- Cytochrome c, somatic
- Acyl-CoA desaturase 1
Sequence:
MAEQSDKDVKYYTLEEIQKHKDSKSTWVILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTDARELSKTYIIGELHPDDRSKIAKPSETLITTVESNSSWWTNWVIPAISALVVALMYRLYMAED
Protein: CLC channel (Q5B023)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPRSIPSYFTSAPPAEEHHDPENVSPGPRLNPRTAPPSPSVMRRTYSHLSESHTAYQSLEPPLEAGETTSLLGKAKEGGSGRMEPQRSYTTFSASSGPESGFRYTLLGSSLRRSRHHSRANSVHQRFSRRASMDEVPVESTAASIKDAMTSSFMDDRLWYDQFTSTDWVHDSVADGVRLRELRRRKDIRGRLLALFDGAQGWILVALIGCIVAAIAYFVDITEEYVFGLKNGICTTGWLRSRETCCADEEECPAWRSWSEMMNHHGGGSVSVDFGIYVLWSVILAAISCLLTLLTKTVVPSSVSLTTLDENLGANGSRQATEADGSPASVSGSSPYPPLPLRPDMVYYSAAGSGVAEVKVINSGFVLHGYLGFKTLVIKTLALIFSVASGLSLGKEGPYVHIATCVGNIACRLFSKYNLNDGKRREVLSASAASGVAVAFGAPIGGVLFSLEEVSYYFPPKTLFRTFFCCIAAALSLKFFNPYGTGKIVLFEVRYLGDWEIFELAIFMFLGVLGGAAGALFIKASSIWAKSFRRIPVIKRWPLFEVGLVALVTGLISFWNPYTKLPVTELLFQLASPCEHSTSDGLCPHPEGIGEVIRALTIAFVIKSFLTIVTFGIKVPAGIYVPSMVVGGLMGRIVGHVTQYLALQYPNFFLFGSSCAAGTGMESCVTPGVYAMVAAGATMCGVTRLSVTLAVILFELTGSLDHVLPFSLAVLCAKWTADAIEPHSIYDFLTEMNSYPFLDNKLQTVSDAVLGDIVRPIRRSRLIDITETPLVPARELRSKLQHLLMAGELDSGLPILRDGVLIGLIPAPDLEYALDNLEDEDRTSCLMATDTSSVVSDTDDEDTLQVDFTKYIDPAPLALDIHSPIDLVYQCFVKLGLRYLCVLHDGQYAGLVHKKAFVKFMKEQH
Protein: Heat shock protein 90-2 (AtHSP90.2) (AtHsp90-2) (Heat shock protein 81-2) (Hsp81-2) (Protein EARLY-RESPONSIVE TO DEHYDRATION 8) (Protein LOSS OF RECOGNITION OF AVRRPM1 2) (Protein MUTANT SNC1-ENHANCING 12) (P55737)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular chaperone. Involved in RPM1-mediated resistance. Component of the RPM1/RAR1/SGT1 complex. May stabilize RPM1 and protect it from SGT1-mediated degradation. Associates with RAR1 which may function as co-chaperone. Possesses ATPase activity. In the absence of heat shock, negatively regulates heat-inducible genes by actively suppressing heat shock transcription factor A1D (HSFA1D) function. Involved in the induction of heat shock transcription factor A2 (HSFA2) expression in response to oxidative stress. Required for stomatal closure and modulates transcriptional and physiological responses to abscisic acid (ABA). Regulates RPP4-mediated temperature-dependent cell death and defense responses. May assist SGT1B in the formation of SCF E3 ubiquitin ligase complexes that target the immune receptors SNC1, RPS2 and RPS4 for degradation, to regulate receptor levels and avoid autoimmunity.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Protein SGT1 homolog A
- Protein SGT1 homolog B
- Cysteine and histidine-rich domain-containing protein RAR1
- Peptidyl-prolyl cis-trans isomerase CYP40
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 1
- Heat shock 70 kDa protein 3
- Co-chaperone protein p23-1
- Co-chaperone protein p23-2
- Ankyrin repeat family protein
Sequence:
MADAETFAFQAEINQLLSLIINTFYSNKEIFLRELISNSSDALDKIRFESLTDKSKLDGQPELFIHIIPDKTNNTLTIIDSGIGMTKADLVNNLGTIARSGTKEFMEALAAGADVSMIGQFGVGFYSAYLVADKVVVTTKHNDDEQYVWESQAGGSFTVTRDTSGETLGRGTKMVLYLKEDQLEYLEERRLKDLVKKHSEFISYPISLWIEKTIEKEISDDEEEEEKKDEEGKVEEVDEEKEKEEKKKKKIKEVSHEWDLVNKQKPIWMRKPEEINKEEYAAFYKSLSNDWEEHLAVKHFSVEGQLEFKAILFVPKRAPFDLFDTKKKPNNIKLYVRRVFIMDNCEDIIPEYLGFVKGIVDSEDLPLNISRETLQQNKILKVIRKNLVKKCLELFFEIAENKEDYNKFYEAFSKNLKLGIHEDSQNRTKIAELLRYHSTKSGDELTSLKDYVTRMKEGQNDIFYITGESKKAVENSPFLEKLKKKGIEVLYMVDAIDEYAIGQLKEFEGKKLVSATKEGLKLDETEDEKKKKEELKEKFEGLCKVIKDVLGDKVEKVIVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDSSMAGYMSSKKTMEINPENSIMDELRKRADADKNDKSVKDLVLLLFETALLTSGFSLDEPNTFGSRIHRMLKLGLSIDDDDAVEADAEMPPLEDDADAEGSKMEEVD
Protein: Thioredoxin-1 (Thioredoxin I) (TR-I) (Thioredoxin-2) (P22217)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:8603912}. Golgi apparatus membrane {ECO:0000269|PubMed:22984289}; Peripheral membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Thioredoxin reductase 1
- Thioredoxin-2
- AP-1-like transcription factor YAP1
- Peroxiredoxin TSA1
- Transcription factor SKN7
- Thioredoxin reductase 2, mitochondrial
- Glutathione reductase
- Peroxiredoxin PRX1, mitochondrial
- Peroxiredoxin AHP1
- Glutaredoxin-2
Sequence:
MVTQFKTASEFDSAIAQDKLVVVDFYATWCGPCKMIAPMIEKFSEQYPQADFYKLDVDELGDVAQKNEVSAMPTLLLFKNGKEVAKVVGANPAAIKQAIAANA
Protein: Flagellar basal body rod protein FlgB (O26081)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Subcellular location: Bacterial flagellum basal body {ECO:0000256|ARBA:ARBA00004117, ECO:0000256|PIRNR:PIRNR002889}.
Interaction partners:
- Flagellar basal-body rod protein FlgC
- Flagellar hook-basal body complex protein FliE
- Basal-body rod modification protein FlgD
- Flagellar M-ring protein
- Flagellar biosynthetic protein FliP
- Flagellar basal-body rod protein FlgG
- Flagellar P-ring protein
- Flagellar L-ring protein
- Flagellar biosynthetic protein FliQ
- Alternative transcription initiation factor, sigma-F
Sequence:
MDFSKAFGLVYKALDYRSLRQDMIASNIANVDTPFYRPKDLDFESVLAKKKAEIFENQSSKVLPLAHTNPRHLDFENSAKDGASLFFRDGHLAKNDGNSVDLDIETSEMGKNSTMYLALSSALKKYRGVINYAIDSSKNL
Protein: Hydrogenase expression/formation protein HypE (Q5JII7)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Interaction partners:
- hydrogenase expression/formation protein HypD
- Hydrogenase expression/formation protein HypC
- Carbamoyltransferase
- Hydrogenase maturation factor HypA
Sequence:
MGEKIKLEHGAGGEIMEELLRDVILKTLTLKSAGGIGLDALDDGATIPFGDKHIVFTIDGHTVKPLFFPGGDIGRLAVSGTVNDLAVMGAEPIALANSMIIGEGLDMEVLKRVLKSMDETAREVPVPIVTGDTKVVEDKIEMFVITAGIGIAEHPVSDAGAKVGDAVLVSGTIGDHGIALMSHREGIAFETELKSDVAPIWDVVKAVAETIGWENIHAMKDPTRAGLSNALNEIARKSNVGILVREADIPIRPEVRAASEMLGISPYDVANEGKVVMVVAREYAEEALEAMRKTEKGRNAAIIGEVIADYRGKVLLETGIGGKRFMEPPEGDPVPRIC
Protein: Phosphoglyceromutase (Q24450)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRHGESEWNQENQFCGWYDANLSEKGGSSRAQGRQGCRPGVRCGPHLGANPRPGDAGQHPEASGHKEIPNPEDLAPERAPLRWTHWPEQGRDRRQVRRGPGADLASQLRHPATTDGAGPSVLREHRQGSPLRRGSQARGVPPVRVPQADHRAHTALLERRHHSPDEGGQAHPDRCPRQQPPWHRQAFRQPF