wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleolar protein dao-5 (140 kDa nucleolar phosphoprotein) (Nopp140) (Dauer or aging adult overexpression protein 5) (Q9XVS4)
Organism: Caenorhabditis elegans
Function: Nucleolar protein which binds to RNA polymerase I and rDNA and is required for efficient RNA polymerase I-mediated rDNA transcription. Maintains the epigenetically active status of rDNA chromatin which facilitates rDNA transcription and sustains germline development, ensuring fertility. Plays a role in the modulation of nucleolus size. May play a role in the regulation of lifespan.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:20405020, ECO:0000269|PubMed:22768349, ECO:0000269|PubMed:24722283}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20405020, ECO:0000269|PubMed:22768349}. Note=Prior to fertilization, during the diakinesis stage of meiotic prophase, transcription ceases and mature oocytes harbor no nucleolus. During this time, localizes to nucleoli of transcriptionally active cells in the rest of the gonad. From the 2-cell stage of embryonic development, localizes to the nucleoplasm. Localizes to nucleoli upon their development in 6- to 8-cell stage embryos. Localizes to the nuclear periphery in developing embryos. In postembryonic cells, predominantly localizes to the nucleolus, but also localizes to small punctate structures throughout the nucleoplasm. Co-localizes with rDNA and fib-1 in nucleoli. {ECO:0000269|PubMed:22768349}.
Interaction partners:
- Nucleolar protein 56
- rRNA 2'-O-methyltransferase fibrillarin
- Putative H/ACA ribonucleoprotein complex subunit 4
- Nop domain-containing protein
- Ribosomal L1 domain-containing protein
- Nucleolar protein 6
- 26S rRNA
- Nucleolar complex protein 2 homolog
- Guanine nucleotide-binding protein-like 3 homolog
- Uncharacterized protein F23B12.7
Sequence:
MSSDLYANAVLYSEISQRNPELVSKMFNEATRKKLDAFLKDNEAPKLKDIVTDNVFKKRKRIASSSGNEPPVKKMAAKDSSDSDSSDDGAVKKNGVQKPVNVAAKKSATPVQKKAESSSSSDSDAPAKKLTPVKKPAQTPAQKKAASSSDSDSDDEPPKKAPAVTTKVAPKPMAKKQDTSDSDSDSEDSDDGKSKKANPVKVTPVANVLQKVVAKKAASSSSDSSDDEKKPAAKPTPAKPTPKPVVKKAESSSDSSDDEKKPVAKPAPAKATPKPAAKKADSSSDSSDDEAPAKKTPAKAAPKPVAKKAESSSDSSDDEKKPAAKPTPAKATPKPVAKKAESSSDSSDDEKKPVAKPAPAKATPKPVAKKAESSSDSSDDEKKPAAKPTPAKATPKPVAKKAESSSDSSDDEKKPVAKPTSAKATPKPAAKKADSSSDSSDDEAPAKKTPAKAAPKPASKKAESSSDSSDDEKPAAKSTPAKITPKPTAKKVASSSSDSSDDEKKPAAKPTPANATPKPVAKKAESSSDSSDDEKKPVAKPTSAKATPKPAAKKADLSSDFSDDEAPAKKTPAKAAPKPASKKAESSSDSSDDEKPAAKSTPAKTTPKPTAKKAASSSSDSSDDEKKPVAKPTSAKATPKPAAKKADSSSDSSDDEAPAKKTPVKPTPVKIVAKKVDSSSDSSDDEKKPTKATPVKVTPKSVTKKAAASSSDSSDDEKKPVVKQTPNVVPKKEKAASSSDDSSDDEKKPTAKPTPKATPKQSAKKADSSDDSSDDEAPAKKTPAKSTPAKTAVKKEASSSSDDSSDDEKTKKKSATTPAKSTPKTALKKAESSDSSDDDEDLPKPSKAVTPRPQRADSEESAETEESSSRTPALKAKPLATSTEKAVYENRKRKSSPFRRVQMTKDSVSEKFRNNQHDSHFDQWGQRANESLGKVVGKAFRHEKTKKKKGSYGGGPINQSINSIKFSDSDD
Protein: ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) (P08183)
Organism: Homo sapiens (Human)
Function: Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:35970996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35970996}.
Interaction partners:
- Cytochrome P450 3A5
- Immunoglobulin kappa variable 2D-29
- Cytochrome P450 3A4)
- Solute carrier organic anion transporter family member 1B1
- Cytochrome P450 2C19
- Solute carrier organic anion transporter family member 1B3
- Nuclear receptor subfamily 1 group I member 2
- ATP-binding cassette sub-family F member 2
- Peptidyl-prolyl cis-trans isomerase G
- Signal transducer and activator of transcription 3
Sequence:
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
Protein: WD repeat protein (AFU_orthologue AFUA_1G14670) (Q5BF72)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- COMPASS component cclA
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Mitochondrial division protein 1
- COMPASS complex subunit Sdc1, putative
- Peptidase family M20/M25/M40 protein
- Polyadenylation factor subunit 2
- RNA polymerase I specific transcription initiation factor Rrn7, putative
- PHD transcription factor, putative
- WD repeat protein
- Histone H3
Sequence:
MNLSLVDPFVLAQDYPDTLSEKLRSGHATCLRFNRKGDYLASGRVDGTVVIFDVETNGVARKLKGHIRQIQSLSWSRDGRYLLSSSQDWKCILWDLKDGSRVRTVRFEAPVYIAELHPYNHLLFVASLFEDQPVLVDISSPKPVKRILPSAPFRAAPSKDEEIDPAVAAKQAAQDAKHSTCVTIFTALGNHIIAGTSKGWINIIETQTCTTIHSTKLCAGVIILLRLASNGRDLLVNSSDRVIRTILMPDLSQLGIDLEPTNIKLQVEHKFQDVVNRLSWNHVAFSSTGEFVTASTFMNPDIYVWERSHGSLVKILEGPREELGVVEWHPTRPFVVACGLESGCIYTWSIVTPQKWSALAPDFGEVEENVIYVEREDEFDIHPAEEIHQRRLDAEDEEPDVLTIEPSKSGDDIESFRMPVLLDISDSESEEDIVAVGPGTMRRRSPGTGRDKSNANGDGEKDGRNGTTGRGAKGRRR
Protein: Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) (ARPP-90) (A2ALS5)
Organism: Mus musculus (Mouse)
Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Ras-related protein Rap-1b
- Ras-related protein Rap-1A
Sequence:
MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC
Protein: Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2) (Q96GC6)
Organism: Homo sapiens (Human)
Function: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000269|PubMed:10777669}.
Interaction partners:
- Histone-lysine N-methyltransferase SETDB1
- Transcription intermediary factor 1-beta
- TNF receptor-associated factor 6
- Tumor necrosis factor receptor superfamily member 16
Sequence:
MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKPDVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS
Protein: Melanocortin-2 receptor accessory protein 2A (zMRAP2a) (F8W4H9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Inhibitor of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role during larval development in the control of energy homeostasis and body weight regulation by decreasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP, leading to stimulate growth during larval development. Acts by stabilizing an inactive conformation of mc4r during embryonic development, when all the energy consumed is obtained from the yolk sac, possibly to speed the rapid maturation to the mobile free-feeding juvenile stage reached at 5 dpf.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Melanocortin 2 receptor.
- Melanocortin receptor 5
- Melanocortin receptor 5
- Melanocortin receptor 4
- Melanocortin 3 receptor
Sequence:
MPRFQLSNSTSVPNHNYEWSYEYYDDEEPVSFEGLKAHRYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHPEAAEPYEKRMRLTSCADGLGRQRETDGRTGLSRPLLEESRSLFHCYINEEEREGGRAATDAGALTHGRSGIGNSRGQVEEVGLVVQNMVLESRAEREAALLAHFNIPNFVNSELNSALGDEDLLLGDPPIIMEEARPRCTHHIID
Protein: Regulator of G-protein signaling 10 (RGS10) (O43665)
Organism: Homo sapiens (Human)
Function: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.
Subcellular location: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:11443111}. Nucleus {ECO:0000269|PubMed:11443111}. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. {ECO:0000269|PubMed:11443111}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10791963}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Rho guanine nucleotide exchange factor 11
- Rho guanine nucleotide exchange factor 1
- Guanine nucleotide-binding protein G
- Beta-adrenergic receptor kinase 1
- Regulator of G-protein signaling protein-like
Sequence:
MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT
Protein: Rab guanine nucleotide exchange factor SEC2 (GDP-GTP exchange factor SEC2) (Q5AL49)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis (By similarity). Required for filamentous growth.
Subcellular location: Bud neck {ECO:0000250}. Bud tip {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:20639857, ECO:0000269|PubMed:20693302}. Note=Localizes to the spitzenkorper, a structure found in fungal hyphae which is the organizing center for hyphal growth and morphogenesis.
Interaction partners:
- Ras-related protein SEC4
- Rab family GTPase
- Exocyst complex component SEC15
- Cell division control protein 42 homolog
- Exocyst subunit
- Exocyst complex component EXO84
- Mlc1p
- Exocyst complex component Sec8
- SNARE-binding exocyst subunit
- Exocyst complex component SEC5
Sequence:
MSSQADYDKRLAEEVGSLSTRLVTAVNKQVELEETILELRKQVSALKLKNEQLNQSDIKLKTILPKYIKLQDDYRETLTKKKEAESQNTKLQGEVEDLTASLFDEANTMVSNASRETHNFKIKNRKLYEELDEKNIIINDLQEQLQDLKQMFIKMEEQSKIQSYSQSNTPKIESSTDFNETNSIHTNTNFSESKLSKYNTRSTLGDEESQNYNLQQLQRIIYSPLITSIRFDLNNYNIDFKGFVYQLIKPDFQFDLSHLKTIPFFKSIWQSEIENCIHYIPSLPATTTLLNRWQKGKTFWGSLIEGKVSIEPIKGSNETFKLTYKGNNASGNSSNENTESISNRSSATGSVVPVAIKDPCTFCGEARNDSLEHCRLYHLKLFESNTANNSGNNSTNQDQQGNNDNTHVIASYPLCNYCLIKLRNLCDFFAKIRLIRSNIFKLKQNDSFDEFIVVPGSFGQFKRSNTISNRNGTYSSSSTSSSSTSSVSSSSATTANGESLNSTTHNIQLERTEESKLIKLYIMMLLIRSKIFWSKLGFWDTIDQINEINLDEIHYEAFSYLIPKPTQQQQQQQGDIRSQSNFNSPRQSVDGRSVLSGSISSPRQPNLDKQQKDSIVDETVAQLQRDGVVRSETASAEEKFEDAISDETNGQEQLRSEKLQTGKTVTEPNSVSESEPVQEPEQVRSKSNNNTNNKNKDTKIEDSDAEHTFSLKRSHSKQFKDQLNKELDQTLEMLAENIDFDESSNGNGNGN
Protein: Ubiquitin-conjugating enzyme E2 PEX4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme PEX4) (Peroxin-4) (Peroxisome biogenesis factor 4) (I1RRW0)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: Ubiquitin-conjugating enzyme E2 that is essential for peroxisome biogenesis and plays a key role in development, pathogenicity, and cell wall integrity. Required for long and very long-chain fatty acid utilization and is involved in lipid droplet accumulation and the elimination of reactive oxygen species. Controls the expression of proteins involved in protein biosynthesis, fatty acid metabolism, cell wall synthesis, oxidation-reduction reactions, as well as of the enzymes involved in the biosynthesis of the mycotoxin deoxynivalenol (DON), including TRI5, TRI6, and TRI10.
Interaction partners:
- HECT-type E3 ubiquitin transferase
- propanoyl-CoA C-acyltransferase
- Peroxisome assembly protein 12
- Ubiquitin-activating enzyme E1 1
- RING-type E3 ubiquitin transferase
- Chromosome 1, complete genome
- Chromosome 4, complete genome
- ubiquitinyl hydrolase 1
- Peroxisomal membrane protein PEX13
- Ubiquitin-conjugating enzyme E2 2
Sequence:
MPPSSSNTAAASRSASKRLIKELETWSREQKEEKGIERLGPVNEGDLMEWEAVINGRGIGQGYDEGRWLVNISIPSTYPLAPPKMTFVTPIVHPNIALQNGEICLDLLKDAWTPAYSVLECVRAVRMLLGCPETDSPLNVDVAALLRSGDVLGTRKLVELWCQDSDSRYEGP
Protein: Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (InsP6 kinase KCS1) (PKC1 suppressor protein 1) (Q12494)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- Inositol-pentakisphosphate 2-kinase
- Inositol polyphosphate multikinase
- Phosphate system positive regulatory protein PHO81
- Protein BMH2
- Diphosphoinositol polyphosphate phosphohydrolase DDP1
- PHO85 cyclin PHO80
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
Sequence:
MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD
Protein: Uncharacterized protein Rv1278 (P9WM41)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Calcineurin-like phosphoesterase domain-containing protein
- Uncharacterized GMC-type oxidoreductase Rv1279
- DNA polymerase I
- DNA topoisomerase 1
- Protein RecA
- 5'-3' exonuclease
- Proteasome-associated ATPase
- ERCC4 domain-containing protein
- Multifunctional non-homologous end joining DNA repair protein LigD
- Uncharacterized protein Rv1276c
Sequence:
MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALDLLLEYKDRSTKKEVKQVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLAPRREQLTGDEAHERVRTMLAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDDAALSGTESLLIERIEAEYARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDGVRRHTELTEQVAELSQQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGASTAAHAGRLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVLTAVRLRAESARRTLDQLADCEEADRLAARLARIDDIEGDRDRVCAELSAVTLTEELLSRIERAAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVSLSAGQSWSVTATGPTEVKVPGVLTARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELLSRRDQLTATLAGLCGDEQVDQLRSRLEQLCAGQPAELDLVSTDTATARAELDAVEAARIAAEKDCETRRQIAAGAARRLAETSTRATVLQNAAAAESAELGAAMTRLACERASVGDDELAAKAEADLRVLQTAEQRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVELSVFGTQGRKGKLDAAETEREHAASHHARVGRRARAARLLRSVMARHRDTTRLRYVEPYRAELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGGAKEQLGILARLAGAALVAKEDAVPVLIDDALGFTDPERLAKMGEVFDTIGADGQVIVLTCSPTRYGGVKGAHRIDLDAIQ
Protein: SWIM-type domain-containing protein (Q21875)
Organism: Caenorhabditis elegans
Interaction partners:
- Elongin-C
- Cullin-2
- RNA polymerase II transcription factor SIII p18 subunit
- Protein sax-3
- RING-box protein 1
- Sex-determining protein fem-1
- Zyg eleven-related protein 1
- Early embryogenesis protein zyg-11
- Leucine-Rich Repeat protein
- von Hippel-Lindau tumor suppressor homolog
Sequence:
MLPNAVGNNVWNGRDDVSFEDSERFEEDSQVSLDESLDGNSQNWRGWTDCQSNCEAIQPGLSCVVYQHYSASGRFSSASTRTVVPGDPNNPLSQHPMMSRGDDSIGTLLTLSEISARVCAEKWSFQQLEEMYSHICTSRAEKLAMPPPISTIPEKIFLSFIVHCFPQSTDEIRMYSTLANGSSEQYELGKTIYEWGNVRDVSQTGFLLSGNISNSTHPDTRPIQYDDNSSFHVTVKVDRCRIVECTCECSNRSSWCKHVVALSIYRIYERSNIKFKETIADAINSMSDFDLRRLVQWHINEIPRKCIPGFQKLIDQIKDPHSNINNLHGAPDPTDGGHDPVSRYDFPEIESKIRRLLIKYCVPAPSVHCDIQYLTATHHPTHIEWTTMIKPLRCRDPEGMWNLLQMIREMFARNDENAVALLRTVTDECLSNHQVLLWWYITKLVQSGHWAQTSCFKVPNSQMLAQLNCSQLCDEIVILWKLVALNPRAGKLYRSQLVPYLQDYHRTAVNRLKNMITLAPPIPAEVTQTTDATVLSNHQTAAILQTITNMDIRYPLSSQNMKFTLNCFPGFYPAIQMCNYLNEKDIRFGVPTDAIFYVDAPNLSNSYKMVPPHREKVLKKKKKKKKLLKRKVEEDGPSWRRNEYQGVDGIWRVLNEADAGNNDSTESGQESDVQKTPQRVEIPRKKKVDSVEMDVNEVLAAAFTPLDALDARFLRVEAYGTHGYRADAIQHALQVIEYLIDSLTEQSNDFRNVHGVENEPSTSKQSSSSSSSTVSDDVTVADRDEEIARGCKFLATMEKILYITKVLKDNQNLQQIVFDISMRCLTITKYPFFTKNHQIMFTYLETEFVGILDQIWQTVPMSDTQIRKIRERASEIIESDSGNNGELPPIAMTKFLFLALYWTEPPSTSIRPVPAQSVPPTASPALQHNRRLLNSTDSDLALHVSLHIIGCRPYISDRYILHWETIRREKSELTSMLLVRYKDSQEKCALVIDRILDPKLHRMYQNHLSNAAYFLERCPTYQRRFQPGQRPVFPYRDDQAQEPVPESAPNRCLIADYEAQIEAELQRMIDSEMIPRPPALITRSRPSNEDARSSSSSDNSGYTNRNSGSTHSHSTESIDDSQPGPSMSTTDSSATKKSNSIVRKPRRRTNRSLSFDTGNTVSDAHVYHMNELSKKILFEAGGSLNNVIWGNPVTGGTNRRLHLCAIAIACYALGMSNRISPNWNTRTYNNISSWVTSQVQEIGPNAIELIREIWMAHFTPNEIAQISERSAPASDASMKREAAKLALSVLPFAHALTDEEVINALTKCRSDSRDMMIAGLLAMDTPQFREIGRSRPLFSAMFYWNELNAEEESRQQQQHQYQQQPPPQARLVPNPYQIMTNNRNIQKQQQNQQQHQLQRPNNAPQPQRLQVPALPPAAYHLYPQAYEIVEPIANLPPGYRNDISRLHQSHSAPQLGGNPAETNQEEHIPVVVPTANHQYMPPAQLGNALLNAYYYGMRAMDCMATSPGEERQMYLKFGPNAPYSDELKVLNFIAHKLGGPYLHSFYSNASRSVLSPYILHQFATDSARYFPHRMFNQNLPGGNVPYPLFPPNMVAVPSPMPSNIRYPNIRFSTPGQITTLFIANGFQPITGELYERCCEQYLQAIVNKMNSPRVTSDVEYINQLLEFIQRAHEAFKWFPNGGSQLFDSFVRAFKRQKSFKKDFANDINNFLGQLSPL
Protein: Fe-S cluster assembly factor HCF101, chloroplastic (Protein HIGH CHLOROPHYLL FLUORESCENCE 101) (Q6STH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for photosystem I (PSI) biosynthesis and assembly. May serve as a chloroplast scaffold protein that specifically assembles iron-sulfur (4Fe-4S) clusters and transfers them to the chloroplast PSI and ferredoxin-thioredoxin (FTR) complexes. Can assemble a 4Fe-4S cluster and transfer it to apoproteins in yeast cells. Probably not required for assembly or stability of plastidic 2Fe-2S clusters.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:14645254, ECO:0000269|PubMed:14690502}.
Interaction partners:
- NifU-like protein 3, chloroplastic
- NifU-like protein 2, chloroplastic
- NifU-like protein 4, mitochondrial
- Protein NAR1
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- NifU-like protein 5, mitochondrial
- Monothiol glutaredoxin-S14, chloroplastic
- NifU-like protein 1, chloroplastic
- SufE-like protein 1, chloroplastic/mitochondrial
- Iron-sulfur cluster assembly protein 1
Sequence:
MPLLHPQSLRHPSFEIQTQRRSNSTTRLLLSHKFLHSQASIISISRTRILKRVSQNLSVAKAASAQASSSVGESVAQTSEKDVLKALSQIIDPDFGTDIVSCGFVKDLGINEALGEVSFRLELTTPACPVKDMFENKANEVVAALPWVKKVNVTMSAQPAKPIFAGQLPFGLSRISNIIAVSSCKGGVGKSTVAVNLAYTLAGMGARVGIFDADVYGPSLPTMVNPESRILEMNPEKKTIIPTEYMGVKLVSFGFAGQGRAIMRGPMVSGVINQLLTTTEWGELDYLVIDMPPGTGDIQLTLCQVAPLTAAVIVTTPQKLAFIDVAKGVRMFSKLKVPCVAVVENMCHFDADGKRYYPFGKGSGSEVVKQFGIPHLFDLPIRPTLSASGDSGTPEVVSDPLSDVARTFQDLGVCVVQQCAKIRQQVSTAVTYDKYLKAIRVKVPNSDEEFLLHPATVRRNDRSAQSVDEWTGEQKVLYGDVAEDIEPEDIRPMGNYAVSITWPDGFSQIAPYDQLEEIERLVDVPPLSPVEV
Protein: Metallophosphoesterase, isoform B (EC 3.1.3.-) (A1Z8S4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASLRVVNRNRLVCRGFVALTLLLVFFNEFIVYYMAQSSWQPIDCKLDNCTRLLLIADPQILGNSYDRSSHSPLARYDSDRYLAKTFERALAFTQPHIIVFLGDLLDEGNIATAQEYKQYVQRFRRIYQNKNYKKRVHVPGDNDIGGENGDYISNSNQRRFENEFMSEDLFDYDNRLRFFKINRMLLDFSNPDRDNNADRLRIGVSHAPLLIGGGPLLRAIISDLDPHIIFSGHWHESRIFIYPSTKVINFYENSVRHFDLKALKEQEHSYLEIMVPTCSYRMGKSKIGLGYAVLENYNLSYTVLWQPNRFILLFTYVFWGLFVVCGFVVFKMMTRCPFRVAKRQTLYNRVSTIPQF
Protein: Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (A0A8I6A003)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MCFWTELSVWVVLVSHSFSLASSTETSKALTQDNSRVGSHSLLEVLRVLSAGDDRSLNHPQSLIKILLERTGCPQRTDGTQEDCKLCLEPDALSLTAGGDLEDELREEVVQRVSLLLLYYIIHQEEICSSKLNMSNREYEFYLHSLLSLRQDEDSYFLSEKETDDILASTRKYFGTSTSPCMETKILQRESGIQSSNGADEKMLPQLAATIIALSLQGVCLGRKDSPSPDDFTEYIFSFLNRTNALHLSELEELLNMLSTRRACTKINTLHEHQRKQNTAVHGLRDPKSAAAMDKVSGDHSVSWDQACFSAQQLVEIFLQNHSSLSISKEDFKQLSPGIIQQLLSCSCQVPRDQKAKPPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYSLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAELGHFHESQSPIWKLLGLLGGIHGFFLIEKCFILLVSPNTKKGPEDSQTAELPKGNVPASNRNRKTISLLAVMVLVGDGLHNFADGLVIGTAFSSSLESGVTTTIAILCHEIPHEMGDFAVLLSSGLSIRTAILMNFLSALTAFIGLYIGLSVSADPRVQDWILTVTAGMFLYLSLVGMLPEMTHVQTQRPWMTFLLQNVGLVLGWFSLLLLAVYEQNIKI