wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein CONSTANS-LIKE 6 (Q8LG76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- B-box zinc finger protein 32
- B-box zinc finger family protein
- B-box zinc finger protein 18
- At1g52870/F14G24_14 family protein)
- TORTIFOLIA1-like protein 4
Sequence:
MMKSLASAVGGKTARACDSCVKRRARWYCAADDAFLCHACDGSVHSANPLARRHERVRLKSASAGKYRHASPPHQATWHQGFTRKARTPRGGKKSHTMVFHDLVPEMSTEDQAESYEVEEQLIFEVPVMNSMVEEQCFNQSLEKQNEFPMMPLSFKSSDEEDDDNAESCLNGLFPTDMELAQFTADVETLLGGGDREFHSIEELGLGEMLKIEKEEVEEEGVVTREVHDQDEGDETSPFEISFDYEYTHKTTFDEGEEDEKEDVMKNVMEMGVNEMSGGIKEEKKEKALMLRLDYESVISTWGGQGIPWTARVPSEIDLDMVCFPTHTMGESGAEAHHHNHFRGLGLHLGDAGDGGREARVSRYREKRRTRLFSKKIRYEVRKLNAEKRPRMKGRFVKRSSIGVAH
Protein: U3 small nucleolar RNA-associated protein 21 homolog (U3 snoRNA-associated protein 21) (O14053)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Probable U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 4
- Ribosome biogenesis protein bms1
- U3 small nucleolar ribonucleoprotein protein mpp10
- Ribosome biogenesis protein enp2 homolog
- Uncharacterized protein C3B8.09
- Uncharacterized WD repeat-containing protein C3D6.12
- Nucleolar protein 58
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 6
Sequence:
MPFAEKKRRTYENAVKPLRKSRIYAPFRSIGHVSNAVPFDIEARGTHFLVTTSVGNTFQTYDCEKLNLLFVGKQLDKEITCLKSFKDFMLVAAGSKIFAYKRGKIIWDIDVEQEHGTVTHLDAFGEWIIACTSSRHVYVWKHASKYSVPELHTTFLPNTNADITSLLHPSTYLNKILLGFSDGALQIWNLRVSKRVHEFQEFFGDGITSLTQAPVLDVLAVGTISGRIVIFNLKNGSILMEFKQDGQVLSCSFRTDGTPILASSNPIGDLSFWDLSKRRIQNVTYNAHFGSLPKIQFLNGQPILVTAGPDNSLKEWIFDSMDGAPRILRSRNGHYEPPSFVKFYGKSVHFLISAATDRSLRAVSLYQDSQSTELSQGSVISKAKKLNVRPEELKLPEITALSSSNTREKYWDNVLTAHKNDSSARTWNWKSKTLGQHVLPTSDGTSVRSVCVSCCGNFGLIGSSKGVVDVYNMQSGIKRKSFGQSSLSGKPVTAVMLDNVNRILVTASLDGILKFWDFNKGNLIDSLDVGSSITHAIYQHSSDLVAVACDDFGIRIVDVQTRKIVRELWGHSNRLTSFDFSDTGRWLVTASLDGTIRTWDLPTGHLIDSISTPSVCTSLTFAPTGDYLATTHVDQVGISLWTNLSMFKHVSTKALRLDDVVEVSAPSVSGEKGISVVEAALNVESNAEDEEDISYRTMDQLDPNLQTLSKLPRTQWQTLINLEAIKARNAPKEVPKVPEKAPFFLPSLKDQSEATVPKQPIATEISKPTAVASIKVSGTEFSTLLHGNDDDAFFEYLKSLGPAKIDLEIRSLDAYPPYEEFILFINIMTRRLSKRRDFELVQACMSVFTKSHEDVLLMHDTPEDTVPVFESLKAWESVHKEENQRLLDLVGYCSGILSFMRT
Protein: Senecionine N-oxygenase (SNO) (EC 1.14.13.101) (Q8MP06)
Organism: Tyria jacobaeae (Cinnabar moth)
Function: NADPH-dependent monooxygenase that detoxifies senecionine and similar plant alkaloids that are ingested by the larvae. Is active towards a narrow range of related substrates with highest activity towards senecionine, followed by seneciphylline, retrorsine, monocrotaline, senecivernine, axillarine and axillaridine.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MFRKFVIMLVLSLLVAAGISQASSASRVCIIGAGYSGLATARYLQDYGLNYTIFEATPNIGGTWRYDPRVGTDEDGIPIYSSNYKNLRVNSPVDLMTYHGYEFQEGTRSFISGNCFYKYMKSFVRHFGLMENIQVRSLVTWVQRTEDKWNLTYMKTDTRKNYTEECDFVVVASGEFSTPKIPHIKGQEEYKGKTMHSHDYKEAESFRGQRVLVIGAGPSGLDVVMQLSNITSKLVHSQHILKSWHIFNQPDFPGNFISKPNVKHFTANGAVFEDDTVEEFDMVIYCTGFYYNHPFLSTLSSGITATENYVMPLYQQVVNINQPTMTFVGICKPFFAKLLDQQAHYSAKLAAGHFKLPSQDKMLRHWLEHVQMLREAQFKITDVNSVGPNVDEYFKALHKEAGVPLLPPVYASVFVFSGKTLLEDLQNYREYDYRIISDTQFKKKYNPREEVCPYDD
Protein: Probable polyamine transporter At1g31830 (Q9C6S5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable cell membrane polyamine/proton symporter involved in the polyamine uptake in cells.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cationic amino acid transporter 7
- Spermine synthase
- Phosphatidylinositol 4-phosphate 5-kinase 7
Sequence:
MQKRRIITVNPSASIEMSQYENNEVPYSSVGADEVPSSPPKATDKIRKVSMLPLVFLIFYEVSGGPFGVEDSVNAAGPLLALLGFVIFPFIWSIPEALITAEMGTMYPENGGYVVWVSSALGPFWGFQQGWMKWLSGVIDNALYPVLFLDYLKSGVPALGSGLPRVASILVLTILLTYLNYRGLTIVGWVAVLMGVFSILPFAVMGLISIPQLEPSRWLVMDLGNVNWNLYLNTLFWNLNYWDSISTLAGEVENPNHTLPKALFYGVILVACSYIFPLLAGIGAIPLEREKWTDGYFSDVAKALGGAWLRWWVQAAAATSNMGMFIAEMSSDSFQLLGMAERGMLPEFFAKRSRYGTPLLGILFSASGVVLLSWLSFQEIVAAENLLYCVGMILEFIAFVRMRMKHPAASRPYKIPIGTTGSILMCIPPTILICAVVALSSLKVAAVSIVMMIIGFLIHPLLNHMDRKRWVKFSISSDLPDLQQQTREYEETLIR
Protein: Exu regulon transcriptional regulator (P0ACL2)
Organism: Escherichia coli (strain K12)
Function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers.
Interaction partners:
- Hexuronate transporter
- Probable HTH-type transcriptional regulator LgoR
- Altronate dehydratase
- Uronate isomerase
- Mannonate dehydratase
- Altronate oxidoreductase
- D-mannonate oxidoreductase
- Galactonate operon transcriptional repressor
- HTH-type transcriptional repressor NanR
- Uncharacterized HTH-type transcriptional regulator YieP
Sequence:
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRYLFAENPVVHLDTATSGSK
Protein: Putative actin-binding protein UNC-115 (O77133)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKFSRPVLSVNHLILGKKCDVCRKKCSGDVLKANDKYFHINCFQCKKCGRNLGETGFYTTPENAYLCPDDFRAVSKEITVKTTTQQAHASSSSAATPKSPEKSNGTTDVSSSGAANATLQQISPLGSPTTCAACDQALHSGQVLLALGLSWHVYCFKCSECSAVLHGEYMSHHGKPLCLRDYNEKFGVKCYECEKFIAGKVLQAGGYKFHPTCARCSRCGSHFGDGEEMYMQGDEIWHPSCEHARTTENIAPTGRAATLSRNEPKYQSTFGQHQAYMYLLPEVEQTYLRHPVMNAKEPNAPQYHVPQGPIKIRKSRMSMLKTGMQRLTEDLEKNIPRPKSPHMDNEEPIELAHYPAAHVPDPDTLPAIEREDFPAPQFPYAVEELKRRLSTSSVENEISDDEYSESDKVDEDKLRKTVETLEKYNDSSIAHVIRQNIEDSHKKQRLPLHWDPRNASRTPSGKKMPHLKFRYDVPINASPSRHLNRPRPWVVWQGGERDQGNNTLPCFHIPEDSRANTLRAATLPTEFGQNLSLENLDTTISSHYSEHSTTESGTAGGPRSAGGAVLRSSLPDMSKPAKQYDLLFLQTTNSELPEDVDRQHLERHLPRDQFEEIFKMSLIEFYKLPEWKRINLKRKHKLF
Protein: Nucleoside diphosphate kinase 1 (EC 2.7.4.6) (Nucleoside diphosphate kinase I) (NDK I) (NDP kinase I) (NDPK I) (ZmNDPK1) (B4FK49)
Organism: Zea mays (Maize)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Involved in transcription regulation (Probable). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds folded G4 with low nanomolar affinity and corresponding unfolded G-rich DNA more weakly. Stabilizes folded G4s regardless of whether they are prefolded or not.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- adenylate kinase
- Thymidylate kinase
- guanylate kinase
- Guanylate kinase 1
- UMP kinase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- UMP-CMP kinase
- UMP-CMP kinase
- Inosine triphosphate pyrophosphatase
- Inosine triphosphate pyrophosphatase
Sequence:
MESTFIMIKPDGVQRGLIGEIISRFEKKGFYLKALKLVNVERSFAEKHYADLASKPFFQGLVDYIISGPVVAMVWEGKSVVTTGRKIIGATNPLASEPGTIRGDFAVDIGRNVIHGSDSIESANKEIALWFPEGPADWQSSQHPWIYEK
Protein: UDP-glucuronosyltransferase 2B2 (UDPGT 2B2) (EC 2.4.1.17) (3-hydroxyandrogen-specific UDPGT) (RLUG23) (UDPGTr-4) (P08541)
Organism: Rattus norvegicus (Rat)
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone.
Subcellular location: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MPRKWISALFLLQISYCFKSGHCGKVLVWPMDFSHWMNIKIILDELVQRGHEVTVLKPSAYFFLDPKKSSDLKFEIFSTSISKDELQNHFIKLLDVWTYELPRDTCLSYSPILQNLVYEFSYFYLSICKDAVSNKQLMTKLQESKFDVLFADPVASCGDLIAELLHIPFLYSLSFSPGHKLEKSIGKFILPPSYVPVILSGLAGKMTFIDRVKNMICMLYFDFWFERLRHKEWDTFYSEILGRPTTVDETMSKVEIWLIRSYWDLKFPHPTLPNVDYIGGLHCKPAKPLPKDMEEFVQSSGEHGVVVFSLGSMVSNMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPLFGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRAVFWIEFIMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLLFMYRFFVKKEKKMKNE
Protein: Phosphatidylinositol 4-kinase LSB6 (PI4-kinase) (PtdIns-4-kinase) (EC 2.7.1.67) (LAS seventeen-binding protein 6) (LAS17-binding protein 6) (P42951)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May play a role in endocytic and/or exocytic pathways.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12361950}; Peripheral membrane protein {ECO:0000269|PubMed:12361950}. Vacuole membrane {ECO:0000269|PubMed:12361950, ECO:0000269|PubMed:12523934}; Peripheral membrane protein {ECO:0000269|PubMed:12361950, ECO:0000269|PubMed:12523934}. Note=Located at both the plasma and vacuolar membrane. {ECO:0000269|PubMed:12361950, ECO:0000269|PubMed:12523934}.
Interaction partners:
- Phosphatidylinositol 4-kinase STT4
- Phosphatidylinositol 4-kinase PIK1
- Phosphatidylinositol 4-phosphate 5-kinase MSS4
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol 3-phosphate 5-kinase FAB1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 3-kinase VPS34
- Polyphosphatidylinositol phosphatase INP53
- Phosphoinositide 3-phosphatase
- Polyphosphatidylinositol phosphatase INP52
Sequence:
MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHASPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETFGRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQKKKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC
Protein: Manganese transporter pdt1 (Q10177)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transports manganese ions into the cell. Regulates cell morphogenesis through control of manganese homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cation-transporting ATPase 5
- Small nuclear ribonucleoprotein F
- Iron transport multicopper oxidase fio1
- Low-affinity iron/zinc ion transport protein fet4
- Endoplasmic reticulum transmembrane helix translocase
- Thiamine repressible genes regulatory protein thi1
Sequence:
MSSQSYYMNDLDDLRSLESSTLNKKDTAINELNPEQNDTRRSTDLLLEDKYGIQTGFSKYWKKCTYGIREYCKFIGPGFLIAVAYIDPGNYSTDLDAGSRFQYKLLFIVFLSNLFAVYLQSLCIRLGSVTGMDLARNCREHYNRYICWSFYVLAEIAIIATDIAEVIGTAVALKILMHIPLVAGVVITILDVLLVLIAWRPEGSMLSVRIFETAVALLVLVVAISFAVVLGRVHIGGAGTVFKGFLPSSTVFSREGLYSSIGILGATVMPHSLFLGSGLVQTRLRDLDVRRGNYTPVGDCSDYRPTHETIKHSLTYSIVEVALSLFTFALFTNSSILIVAGAVFYNTSGADTSDLFSIYDLLKEYVSISCGRLFAVALLFSGMSAGYVCTIAGQIVSEGYINWNLRPWLRRVITRAIAIIPCLVVSAAVGQSGLNQVLNASQVCLSILLPFLTFPLVMFTCSRKVMRVVSDSTNEETGQLIRETHDYSLGWTMTIVTWAIWLFLTALNLLLIVWLGMGVSF
Protein: Protein DA1-related 4 (Protein CHILLING SENSITIVE 3) (Q9FKN7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NB-LRR receptor-like protein that modulates growth, cell death and freezing tolerance in a temperature-dependent manner. May be involved in defense responses.
Interaction partners:
- Protein LSD1
- Disease resistance-like protein CSA1
- Toll/interleukin-1 receptor-like protein
- F8L10.9 protein
- Probable disease resistance protein At5g04720
- PRA1 family protein D
- Disease resistance protein ADR1
- Negative regulator of systemic acquired resistance SNI1
- Protein SGT1 homolog B
Sequence:
MEPPAARVTPSIKADCSHSVNIICEETVLHSLVSHLSAALRREGISVFVDACGLQETKFFSIKQNQPLTDGARVLVVVISDEVEFYDPWFPKFLKVIQGWQNNGHVVVPVFYGVDSLTRVYGWANSWLEAEKLTSHQSKILSNNVLTDSELVEEIVRDVYGKLYPAERVGIYARLLEIEKLLYKQHRDIRSIGIWGMPGIGKTTLAKAVFNHMSTDYDASCFIENFDEAFHKEGLHRLLKERIGKILKDEFDIESSYIMRPTLHRDKLYDKRILVVLDDVRDSLAAESFLKRLDWFGSGSLIIITSVDKQVFAFCQINQIYTVQGLNVHEALQLFSQSVFGINEPEQNDRKLSMKVIDYVNGNPLALSIYGRELMGKKSEMETAFFELKHCPPLKIQDVLKNAYSALSDNEKNIVLDIAFFFKGETVNYVMQLLEESHYFPRLAIDVLVDKCVLTISENTVQMNNLIQDTCQEIFNGEIETCTRMWEPSRIRYLLEYDELEGSGETKAMPKSGLVAEHIESIFLDTSNVKFDVKHDAFKNMFNLKFLKIYNSCSKYISGLNFPKGLDSLPYELRLLHWENYPLQSLPQDFDFGHLVKLSMPYSQLHKLGTRVKDLVMLKRLILSHSLQLVECDILIYAQNIELIDLQGCTGLQRFPDTSQLQNLRVVNLSGCTEIKCFSGVPPNIEELHLQGTRIREIPIFNATHPPKVKLDRKKLWNLLENFSDVEHIDLECVTNLATVTSNNHVMGKLVCLNMKYCSNLRGLPDMVSLESLKVLYLSGCSELEKIMGFPRNLKKLYVGGTAIRELPQLPNSLEFLNAHGCKHLKSINLDFEQLPRHFIFSNCYRFSSQVIAEFVEKGLVASLARAKQEELIKAPEVIICIPMDTRQRSSFRLQAGRNAMTDLVPWMQKPISGFSMSVVVSFQDDYHNDVGLRIRCVGTWKTWNNQPDRIVERFFQCWAPTEAPKVVADHIFVLYDTKMHPSDSEENHISMWAHEVKFEFHTVSGENNPLGASCKVTECGVEVITAATGDTSVSGIIRESETITIIEKEDTIIDEEDTPLLSRKPEETNRSRSSSELQKLSSTSSKVRSKGNVFWKWLGCFPLQPKNLRSRSRRTTALEEALEEALKEREKLEDTRELQIALIESKKIKKIKQADERDQIKHADEREQRKHSKDHEEEEIESNEKEERRHSKDYVIEELVLKGKGKRKQLDDDKADEKEQIKHSKDHVEEEVNPPLSKCKDCKSAIEDGISINAYGSVWHPQCFCCLRCREPIAMNEISDLRGMYHKPCYKELRHPNCYVCEKKIPRTAEGLKYHEHPFWMETYCPSHDGDGTPKCCSCERLEHCGTQYVMLADFRWLCRECMDSAIMDSDECQPLHFEIREFFEGLHMKIEEEFPVYLVEKNALNKAEKEEKIDKQGDQCLMVVRGICLSEEQIVTSVSQGVRRMLNKQILDTVTESQRVVRKCEVTAILILYGLPRLLTGYILAHEMMHAYLRLNGYRNLNMVLEEGLCQVLGYMWLECQTYVFDTATIASSSSSSRTPLSTTTSKKVDPSDFEKRLVNFCKHQIETDESPFFGDGFRKVNKMMASNNHSLKDTLKEIISISKTPQYSKL
Protein: Intelectin (RTInt) (P0DMV4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: May be involved in innate immune surveillance. May specifically recognize carbohydrate chains of pathogens and bacterial components in a calcium-dependent manner. In vitro binds N-acetylglucosamine residues.
Interaction partners:
Sequence:
MKYCVLLIMIHLLLVELPQFPEALQGNVYAAAPVVAATDLRLRIRSSYIGRSCKEIRDRYNQHEDGLYYLSTASGTVYQTFCDMTTAGGGWTLVASVHENNVYGKCTMGDRWSSQQGSNPNWPDGDGNWANRATFGTAEGATSDDFKNPGYYDIVAEDISVWHVPNNSPMEHWNLGAILRYHTERSFLSIQGGNLHQLFKLYPVRYNAEASGNTGPVIPIVYDFGDKETTRELYGPNTRNQFEPGFITFRPINNELAAMAICSGVKPTTGGDTEHYCIGGGGHFPEGAPRQCGDFPAFDWNGYGTNTEWSASKQLTEAAVLLFYR
Protein: Golgi reassembly stacking protein 1 (cDNA FLJ58222, highly similar to Golgi reassembly-stacking protein 1) (B4E1H8)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
Sequence:
MGLGVSAEQPAGGAEGFHLHGDVEPSSPAALAGLRPYTDYVVGSDQILQESEDFFTLIESHEGKPLKLMVYNSKSDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQPPSYHKKPPGTPPPSALPLGAPPPDALPPGPTPEDSPSLETGSRQSDYMEALLQAPGSSMEDPLPGPGSPSHSAPDPDGLPHFMETPLQPPPPVQRVMDPGFLDVSGISLLDNSNASVWPSLPSSTELTTTAVSTSGPEDICSSSSSHERGGEATWSGSEFEVSFLDSPGAQAQADHLPQLTLPDSLTSAASPEDGLSAELLEAQAEEEPASTEGLDTGTEAEGLDSQAQISTTE
Protein: NADPH-dependent codeinone reductase 1-4 (PsCor1.4) (EC 1.1.1.247) (Q9SQ67)
Organism: Papaver somniferum (Opium poppy)
Function: Reduces codeinone to codeine in the penultimate step in morphine biosynthesis. Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11079569}. Note=Present in the cytosolic part of laticifer cells that secrete latex (PubMed:11079569). Localized to the parietal region of the sieve element cytoplasm (PubMed:14508000). {ECO:0000269|PubMed:11079569, ECO:0000269|PubMed:14508000}.
Interaction partners:
Sequence:
MESNGVPMITLSSGIRMPALGMGTAETMVKGTEREKLAFLKAIEVGYRHFDTAAAYQSEECLGEAIAEALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLEYLDLYLIHHPVSLKPGKFVNEIPKDHILPMDYKTVWAAMEECQTLGFTRAIGVSNFSCKKLQELMAAAKIPPVVNQVEMSPTLHQKNLREYCKANNIMITAHSVLGAIGAPWGSNAVMDSKVLHQIAVARGKSVAQVSMRWVYQQGASLVVKSFNEGRMKENLKIFDWELTAEDMEKISEIPQSRTSSADFLLSPTGPFKTEEEFWDEKD
Protein: Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (Serine protease 11) (Q9R118)
Organism: Mus musculus (Mouse)
Function: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves or not. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q92743}. Secreted {ECO:0000250|UniProtKB:Q92743}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q92743}. Note=Predominantly secreted. Also found associated with the plasma membrane. {ECO:0000250|UniProtKB:Q92743}.
Interaction partners:
- Aggrecan core protein
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
Sequence:
MQSLRTTLLSLLLLLLAAPSLALPSGTGRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVIPEEIDP
Protein: Protein FAM50B (Protein XAP-5-like) (Q9Y247)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEKNKHIFPASRWEAYDPEKKWDKYTIR
Protein: Probable di- and tripeptidase DUG2 (EC 3.4.-.-) (Deficient in utilization of glutathione protein 2) (GSH degradosomal complex subunit DUG2) (P38149)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Probable glutamine amidotransferase DUG3
- Cytoplasmic tRNA 2-thiolation protein 2
- Protein ARG5,6
- Glutathione hydrolase proenzyme
- Argininosuccinate synthase
- Cys-Gly metallodipeptidase DUG1
Sequence:
MYDSRGVALHSELIHRWNHAFSILSIVAFPKKRLLFAGSQDSKILVFDLPTYNLIHTIRLGESQEETHTRSSVLCLTGSEDENFLFSGGADSLVRIWSIGEKTIRDDFLPVTEIATVYSVTDIGDIFSLAYLDSLETIVFGCQNASLLYVENLIQKIEKKSSDGVENINKLPHRRYDKFFDSLGPTGYSSNSLSQTSLTSLQENCGAAIIEVPSENIIKYAHYGFIYSINKLCPRFNQLLEKSSRTSGAEHIISSAGDGISKLWEFSKDKGQNTVKISLINDKIDNEDSVISQTIEFPFLYCGLTDGIIKIWDLNTQQIISTLKTKHESDVISISVYMDHVFAIDESGITHFYQNQVNHWNPQQGKILSSEIFSKSNAGSVSLLTGGSDGSLTLWDITSLLSAVPLSSNSPINASSTLQTTNLWAAYQSASLNNEEMLNTLRELISFQTVSQSKDTTNTLSLRRCAIYLQQLFLKFGATNSQLFPLPDGGNPVVFAYFQGNGKVSQVKGAKKKRILWYGHYDVISSGNTFNWNTDPFTLTCENGYLKGRGVSDNKGPLVSAIHSVAYLFQQGELVNDVVFLVEGSEEIGSASLKQVCEKYHDIIGKDIDWILLSNSTWVDQEHPCLNYGLRGVINAQIKVWSDKPDGHSGLNGGVYDEPMVNLVKIVSKLQNEQNEIMIPNFYSPLKDLTEEEYQRFQKITELANIDENTTVQDLITNWTKPSLSMTTVKFSGPGNITVIPKSVTMGISIRLVPEQSVEQVKRDLKAYLEESFKQLKSQNHLEIKVLNEAEGWLGDPTNHAYQILKDEITTAWDVEPLLVREGGSISCLRMLERIFDAPAVQIPCGQSTDNGHLANENLRIKNWSNLTEILSKVFNRL
Protein: DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha) (P0A7Z4)
Organism: Escherichia coli (strain K12)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.
Interaction partners:
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein bS18
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein uL3
Sequence:
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
Protein: General negative regulator of transcription subunit 2 (P87240)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- General negative regulator of transcription subunit 1
- General negative regulator of transcription subunit 3
- Cell differentiation protein rcd1
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- Poly
- Putative general negative regulator of transcription C16C9.04c
- ABC transporter domain-containing protein C20G4.01
- Putative ATP-dependent RNA helicase ste13
- Mitochondrial division protein 1
- Zinc-regulated GTPase metalloprotein activator 1
Sequence:
MSLANRLSHLNITGGNDFKASIGPSVGRQNEATNPWSSTSHSLENSAATVVNELQTTKEQKTPEQSTTANPLFPGNDFSDFNNHKSKLLGVITGKSTPSSQAEKSDTTNSKTGSTEELTETPADENAKQYMLESLLPIIRMEDSEMSTLQLGCDLAALGFDLAPVEEDRLISTNLFSPWAELNTKKPVSQPMFKLPACYKNVNPPPAISKIFQFSDETLFYIFYTMPRDVMQEAAAQELTNRNWRFHKELRVWLTPVPGMKPLQRTPQFERGYYMFFDPIHWKRIKKDFLLMYAALEDRAQSAVHS
Protein: Zinc finger protein GLIS3 (GLI-similar 3) (Q6XP49)
Organism: Mus musculus (Mouse)
Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.
Subcellular location: Nucleus {ECO:0000269|PubMed:14500813}.
Interaction partners:
- Suppressor of fused homolog
Sequence:
MMVQRLGPISPPASQVSTACKQISPSLPRAVNAANLNRPPSDTRSVILQESLVSTTLSLTESQSALSVKQEWSQSYRAFPSLSSSHSSQNGTDLGDLLSLPPGTPVSGNSVSNSLPPYLFGMENSHSPYPSPRHSATRAHSTRSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGPRASPANLSPQSEVYGHFLGVRGSCIPQSCAVASGQKGILVASGGHTLPGYGEDGTLEYERMQQLEHGGLQPGPVNNMVLQPGLPGQDGQTANMLKTERLEEFPASALDLPSALPLPLPPPQGPPPPYHAHPHLHHPELLPHTQSLSLAQTGLEEDGEMEDSGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQARKKLRSSTELHPDLLTDCLAVQPLQPATSPGDAADHTVGHSPGPGPGPGPGAELYSAPIFASNHSTRSGTAAGAGPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPPTPSPHHISPGRVPAPPSLLQRAQAPHSQQPPGSLLKPYQPETNSSFQPNGIHVHGFYGQLQTFCPPHYPDSQRTVPPSGSCSMVPSFEDCLVPTSMGQAGFDVFHRAFSTHSGITVYDLPSASSSLFGESLRSGPEDPTFLQLSAVDRCPSQLSSVYTEG