wanglab/gogpt-training-data huggingface dataset:
Protein: Pumilio homolog 1 (E9PR38)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, P-body {ECO:0000256|ARBA:ARBA00004201}. Cytoplasmic granule {ECO:0000256|ARBA:ARBA00004463}.
Interaction partners:
Sequence:
MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGELFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII
Protein: Mitochondrial outer membrane protein porin 3 (Protein HYPERSENSITIVE RESPONSE 2) (Athsr2) (Voltage-dependent anion-selective channel protein 3) (AtVDAC3) (VDAC-3) (Q9SMX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}. Mitochondrion outer membrane {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:19326079, ECO:0000269|PubMed:21705391}.
Interaction partners:
- Kinesin-like protein KIN-14F
- Mitochondrial import receptor subunit TOM40-1
- Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
- Probable mitochondrial import receptor subunit TOM40-2
- Thioredoxin M2, chloroplastic
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
- ADP,ATP carrier protein
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- At5g19500
Sequence:
MVKGPGLYTEIGKKARDLLYRDYQGDQKFSVTTYSSTGVAITTTGTNKGSLFLGDVATQVKNNNFTADVKVSTDSSLLTTLTFDEPAPGLKVIVQAKLPDHKSGKAEVQYFHDYAGISTSVGFTATPIVNFSGVVGTNGLSLGTDVAYNTESGNFKHFNAGFNFTKDDLTASLILNDKGEKLNASYYQIVSPSTVVGAEISHNFTTKENAITVGTQHALDPLTTVKARVNNAGVANALIQHEWRPKSFFTVSGEVDSKAIDKSAKVGIALALKP
Protein: GEO07678p1 (Niemann-Pick type C-2b, isoform A) (Niemann-Pick type C-2b, isoform B) (RE36503p) (Q9VFN7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Niemann-Pick type C-1a, isoform A
- Niemann-Pick type C-2c
- Niemann-Pick type C-2g, isoform A
- GEO08227p1
- Niemann-Pick type C-2e
- NPC intracellular cholesterol transporter 1 homolog 1b
- NPC intracellular cholesterol transporter 2 homolog a
Sequence:
MKLSLGLFVIFAALIGFTSSTDVSQCPKSKSKALAAGDVSISNCPKSKCILKRNTEASIQMKIRPERDFQELTSDIQGIILDVPLPFPGYYGTSACPHIYDEAGEKKVGCPLKAGQVYTYKNSFKILPVYPTVSLEIHWGLGDKHGDAACFQIPAKIKA
Protein: Receptor-like protein kinase 7 (EC 2.7.11.1) (F4I2N7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in pattern-triggered immunity (PTI) signaling induced by pathogen-associated molecular patterns (PAMPs). Acts as a receptor for PIP1 defense peptide. PIP1 is an endogenous secreted peptide that acts as elicitor of immune response and positive regulator of defense response. Involved in the control of seed germination speed, in tolerance to oxidative stress and in maintaining seed longevity.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- PAMP-induced secreted peptide 1
- Serine rich endogenous peptide 23
- Serine rich endogenous peptide 20
Sequence:
MAPSLRNFNFFHRFSTFLVFSLFSVVSSDDLQVLLKLKSSFADSNLAVFDSWKLNSGIGPCSFIGVTCNSRGNVTEIDLSRRGLSGNFPFDSVCEIQSLEKLSLGFNSLSGIIPSDLKNCTSLKYLDLGNNLFSGAFPEFSSLNQLQFLYLNNSAFSGVFPWKSLRNATSLVVLSLGDNPFDATADFPVEVVSLKKLSWLYLSNCSIAGKIPPAIGDLTELRNLEISDSGLTGEIPSEISKLTNLWQLELYNNSLTGKLPTGFGNLKNLTYLDASTNLLQGDLSELRSLTNLVSLQMFENEFSGEIPLEFGEFKDLVNLSLYTNKLTGSLPQGLGSLADFDFIDASENLLTGPIPPDMCKNGKMKALLLLQNNLTGSIPESYANCLTLQRFRVSENNLNGTVPAGLWGLPKLEIIDIEMNNFEGPITADIKNGKMLGALYLGFNKLSDELPEEIGDTESLTKVELNNNRFTGKIPSSIGKLKGLSSLKMQSNGFSGEIPDSIGSCSMLSDVNMAQNSISGEIPHTLGSLPTLNALNLSDNKLSGRIPESLSSLRLSLLDLSNNRLSGRIPLSLSSYNGSFNGNPGLCSTTIKSFNRCINPSRSHGDTRVFVLCIVFGLLILLASLVFFLYLKKTEKKEGRSLKHESWSIKSFRKMSFTEDDIIDSIKEENLIGRGGCGDVYRVVLGDGKEVAVKHIRCSSTQKNFSSAMPILTEREGRSKEFETEVQTLSSIRHLNVVKLYCSITSDDSSLLVYEYLPNGSLWDMLHSCKKSNLGWETRYDIALGAAKGLEYLHHGYERPVIHRDVKSSNILLDEFLKPRIADFGLAKILQASNGGPESTHVVAGTYGYIAPAEYGYASKVTEKCDVYSFGVVLMELVTGKKPIEAEFGESKDIVNWVSNNLKSKESVMEIVDKKIGEMYREDAVKMLRIAIICTARLPGLRPTMRSVVQMIEDAEPCRLMGIVISKESDVKVKEIS
Protein: AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) (O35643)
Organism: Mus musculus (Mouse)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Interaction partners:
- AP-1 complex subunit gamma-1
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit mu-1
- AP-1 complex subunit sigma-3
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit mu-2
- Intersectin-2
- AP-1 complex subunit sigma-2
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
Sequence:
MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPNAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPAGDQPDVIPAQGDLLGDLLNLDLGPPVSGPPLAASSVQMGAVDLLGGGLDSLIGDSNFGAPSASVAAAPAPARLGAPISSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQAGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHVPLSPNQTVEISLPLNTVGSVLKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGKMDRQMFLATWKDIANENEAQFQIRDCPLNTEAASNKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTLSLKCRAPEVSQHVYQAYETILKN
Protein: Neutrophil cytosolic factor 2 isoform 1 (A0A0S2Z457)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
Protein: Cadherin 11 (F1MAH6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
Interaction partners:
- Catenin beta-1
- Cadherin-2
- Junction plakoglobin
- Catenin alpha-1
- Cadherin 3
- Catenin delta 1
- Catenin alpha-2
- Catenin alpha-2
- Cadherin-1
- Cadherin-13
Sequence:
MKENYCLQAALVCLSMLYHSQAFALERRSHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMELFEITTDYETQDGVVKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNISVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDHPKPLSNQPIVTVSADDLDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (D3ZJU5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATTAGGGPGAAAGAVGAGGAAAASGLAVYRRKDGGPASKFWESPDTVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGTLCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYPSSQEDEEWLRPVMRRDKQVLVHWGFYPDSYDTWVHSNDVDAEIEDAPIPEKPWKVHVKWILDTDVFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRERKASANARKRKHSPSPPPPTATESRKKSGKKGQASLYGKRRNQKDEDEQEDLTKDMEDPTPVPNIEEVLLPKNVNPKKDSENTPVKGGTVADLDEQDEEAVTTGGKEDEDPSKGDPSRSADAGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPIDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGSEEEKMETDPDGQQPEKAENKGENESDEGDKIQDGENEKNSEKERDSDTSEDVKPEEKENEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQHGQPPQQAHQHPGGPGLAPLGAAGHPGMMPHQQPPPYPMMHHQMPPPHPPQPGQIPGPGSMMPGQPMPGRMIPTVAANIHPTGSGPTPPGMPPMPGNILGPRVPLTAPNGMWLHQRL
Protein: Glucosylceramidase (EC 3.2.1.45) (M0R3L8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Lysosome membrane {ECO:0000256|ARBA:ARBA00004207}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004207}; Lumenal side {ECO:0000256|ARBA:ARBA00004207}.
Interaction partners:
Sequence:
MAARFIGLFLFQAISWAYGAQPCIPKSFGYSSVVCVCNATYCDSLDPLTLPALGTFSRYESTRSGRRMELSTGSIQANRTGTGLLLTLQPEEKFQKVKGFGGAMTDATALNILALSPPAQKLLLKSYFSSEGIEYNIIRVPMASCDFSIRIYTYADTPNDFQLSNFSLPEEDTKLKIPLIHRALKMSPRPISLFASPWTSPTWLKTNGAVNGKGSLKGHPGDIYHEAWANYFVKFLDAYATHNIKFWAVTAENEPSAGLFTGYPFQCLGFTAEHQRDFISHDLGPALANSSHDVKLLILDDQRLLLPRWAQVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNMMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASEKTDLETVALIRPDGSAVVVVLNR
Protein: Protein kinase DIK2 (Q7KJQ4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSFLRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQITTKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVFLEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIDQPIFLYSNDDNNVQLPQQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILEKDVRDCERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEERNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNGSLESS
Protein: Cln6 protein (A0PJN2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
SVKAEDKDRTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPIQWFPLNKPSVGDYFHMTYNIITPFLLLKLIERSPRTLPRSIVYVSIITFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTTCKAESHMPGPALLLVVPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRRRLFLDSNGLFLLYSFALTLSLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSQQ
Protein: Yuri gagarin, isoform D (Yuri gagarin, isoform S) (Q8IP47)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLNPSRPASSPPPPPSSASQMCRQVQPTGTSASHPHQESTLKASSPDRCTASTEAMSTEHYRCLIQKLRDTNGDAGDMSFELNSIFLKRLDEIDCLDEHEGDDMHTCQLRLVTFQEWVDFLLHVNSVILGNVSDLEKEAYSKIVACCQSVQVRQQHTLEENRRLREDICAIIERVQHSPHCTDFDFNGISLETLTVNQLRGVGKDPAHAECESEKMSESMKSLVGEIAAKHDEIGELKSQINALDEVVHTARQKLLLKDQCIAQLNQQLHEITRCIESRDQAKMEESPNDTLTADAITSDMLENLSIHDTQESEMLRLLNAELNDLLDLHNKQEFQTIEIRRKRVSCFIEKLVSEREDTLKKLESIRSHLTILQSDLDQSCLISVDPESGPCDLDADAQMLEALRRRLLNLSQLNRELHGKYQRLDTESKIKISELEARIESESSVLQRNSDVLREIAELICSLGSKEFSYNEIYDESSKENPFCTTIADMFARKFEQEQNQVEIECDTKTPSQTRKPTKTTKIPGATAKTNKQQPTPKPSNKPTTTKTIPTKNTTTTFRTSK
Protein: Sperm-egg fusion protein Juno (Folate receptor 4) (Folate receptor delta) (FR-delta) (IZUMO1 receptor protein JUNO) (A6ND01)
Organism: Homo sapiens (Human)
Function: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30517645}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Cell projection, microvillus membrane {ECO:0000269|PubMed:36070373}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Note=GPI-anchored at the oolemma microvilli. {ECO:0000250|UniProtKB:Q9EQF4}.
Interaction partners:
- Izumo sperm-egg fusion protein 1
- Glutamate carboxypeptidase 2
Sequence:
MACWWPLLLELWTVMPTWAGDELLNICMNAKHHKRVPSPEDKLYEECIPWKDNACCTLTTSWEAHLDVSPLYNFSLFHCGLLMPGCRKHFIQAICFYECSPNLGPWIQPVGSLGWEVAPSGQGERVVNVPLCQEDCEEWWEDCRMSYTCKSNWRGGWDWSQGKNRCPKGAQCLPFSHYFPTPADLCEKTWSNSFKASPERRNSGRCLQKWFEPAQGNPNVAVARLFASSAPSWELSYTIMVCSLFLPFLS
Protein: Protein TED1 (Trafficking of EMP24/ERV25-dependent cargo disrupted protein 1) (P40533)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts together with EMP24 and ERV25 in cargo exit from the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GPI ethanolamine phosphate transferase 2
- Endosomal protein P24B
- Protein GVP36
- Protein CWH43
- Glycosylphosphatidylinositol anchor biosynthesis protein 11
Sequence:
MLRCAVKKFAYFATFLTIVANIYIYTYPSFHPEQCSWNCSNKNAPLQKDLTFVDKVKNYFSDVREQWHGSHASAGNDEDIHILAFGDPQIKGIWPKTPYVSRLDTYGNDYYLGHIYDMMQQRLKPQVVTVMGDLFSSQWIGDSEFHNRTKRYISRIFKRDPTSIENIKQQNLDEKGQYKANWPEWGDRFNEILDNVKENEADNQELSFGFGYENIHSWNPDLEDFLIINITGNHDVGYSGDATYQHMTRFHDLFGKDNYWIEYETNTTHPWRIVVLNDLLLEGPALQPEFVEATWIFLNQLNERKFNGSTVLLTHVPFYKREGLCVDGPDTRYYPDAHAPESYKSGLLRSQNHLSESVSNQVLNMIFENGKPGIILTGHDHEGCETVYNKKSTSTWEATKNIESDVFVKEITVKSMMGEFNGNTGLVTGHFNTDSMTWEWTFSLCPFAIQHVWWFAKVSLLVTIFTWSSLLFV
Protein: Carboxylesterase/lipase Culp6 (EC 3.1.1.-) (Cell wall lipase) (Cutinase-like protein 6) (Culp6) (O53581)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Shows esterase and phospholipase A activities. May be involved in cell wall biosynthesis and/or maintenance. Can hydrolyze various substrates, including the p-nitrophenol-linked aliphatic esters pNP-laurate (C12), pNP-myristate (C14), pNP-palmitate (C16), pNP-stearate (C18), pNP-butyrate (C4), phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, 4-methylumbelliferyl heptanoate and palmitic acid and arachidonic acid containing phospholipids. Does not exhibit cutinase activity.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Secreted, cell wall {ECO:0000269|PubMed:19225166}.
Interaction partners:
- Polyketide synthase Pks13
- Probable carboxylesterase Culp3
- MPT51/MPB51 antigen
- Phospholipase Culp4
- Probable carboxylesterase Culp5
- Terminal beta-
- Probable carboxylesterase Culp2
- Long-chain-fatty-acid--AMP ligase FadD32
- Carboxylesterase Culp1
- Diacylglycerol acyltransferase/mycolyltransferase Ag85A
Sequence:
MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPSAVPPGVLPPGPTPAHPHKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKALLLKVTGPIAQQFAPARVQTYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDMNNRCPLTSYVLIGFSQGAVIAGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQVPPSPRGEGAEITLHEVPVLSGLGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQAFSPANLPTTLNTLAGGAGQPVHAMYATPEFWNSDGEPATEWTLNWAHQLIENAPHPKHR
Protein: Oligopeptide transport system permease protein OppC (P0AFH6)
Organism: Escherichia coli (strain K12)
Function: Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Oligopeptide transport ATP-binding protein OppF
- Periplasmic oligopeptide-binding protein OppA
- Oligopeptide transport ATP-binding protein OppD
- Oligopeptide transport system permease protein OppB
- Periplasmic murein peptide-binding protein MppA
- Probable D,D-dipeptide transport ATP-binding protein DdpD
- Dipeptide transport ATP-binding protein DppD
- Dipeptide transport ATP-binding protein DppF
- Probable D,D-dipeptide transport ATP-binding protein DdpF
- Nickel import ATP-binding protein NikD
Sequence:
MMLSKKNSETLENFSEKLEVEGRSLWQDARRRFMHNRAAVASLIVLVLIALFVILAPMLSQFAYDDTDWAMMSSAPDMESGHYFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFGQNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTSGIVIRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDALDPKDR
Protein: SURP motif domain-containing protein (Q57WZ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable eukaryotic initiation factor 4A
- Uncharacterized protein
- Pre-mRNA-processing factor 19
- Splicing factor 3A, putative
- Cell division control protein, putative
- PRP1 splicing factor N-terminal domain-containing protein
- Spliceosome-associated protein, putative
- Sm protein B
- Splicing factor 3B subunit 1, putative
- Uncharacterized protein
Sequence:
MSGEADSTPGIIAPGPELRAKIERSAASLAKRDKRKADEMMAKVLASQRREEFLYFEMTHVFYPFFLQKLNEYRAHPELIPTDKDGAAKGTGAPGTEGAVTSTTTVKAGGIVRREGGTRRSEVLQQAEVEAQRYLEDPFPSKYSLDLLHGTVDIPTTTFNYMTCTAQYVAKYGDRFLQDLTARHRNNAAFRFLNSEDVRHEVLLKLIESYRRILHFDSDEVEDRLERYHSVRYIIDTVCKEKVKYARAAIARQKAALLTDEELREKLEWNVFTVVQNFSASDLGLDAPMPEAVAARRRARFEAPNNVADLPVSGGGDSTKDEHFGAPANGTFVGEQDASREPKPPEGMMAPPTFSPTFISSSLIQPADQPVANSNCRKRTHDDVDGNNSA
Protein: Protein ENHANCED DISEASE RESISTANCE 2 (F4JSE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negative regulator of the salicylic acid- (SA-) mediated resistance to pathogens, including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis, and the downy mildew pathogen Hyaloperonospora parasitica, probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR). Prevents ethylene-induced senescence. Binds to phosphatidylinositol-4-phosphate (PtdIns(4)P) in vitro.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17612410}; Single-pass membrane protein {ECO:0000269|PubMed:17612410}. Cell membrane {ECO:0000269|PubMed:17612410}; Single-pass membrane protein {ECO:0000269|PubMed:17612410}. Endosome membrane {ECO:0000269|PubMed:17612410}; Single-pass membrane protein {ECO:0000269|PubMed:17612410}.
Interaction partners:
- Protein ENHANCED DISEASE RESISTANCE 4
- Serine/threonine-protein kinase EDR1
- Kinesin-like protein KIN-14P
Sequence:
MSKVVYEGWMVRYGRRKIGRSYIHMRYFVLEPRLLAYYKKKPQDYQVPIKTMLIDGNCRVEDRGLKTHHGHMVYVLSVYNKKEKSHRITMAAFNIQEALMWKEKIESVIDQHQESQVPNGQQYVSFEYKSGMDTGRTASSSDHESQFSAAEDEEDSRRSLMRRTTIGNGPPESVLDWTKEFDAELANQNSDNQAFSRKHWRLLQCQNGLRIFEELLEVDYLPRSCSRAMKAVGVVEATCEEIFELLMSMDGTRYEWDCSFQFGSLVEEVDGHTAVLYHRLLLDWFPMIVWPRDLCYVRYWRRNDDGSYVVLFRSREHENCGPQPGCVRAHLESGGYNISPLKPRNGRPRTQVQHLIQIDLKGWGAGYLPAFQQHCLLQMLNSVAGLREWFSQTDERGVHTRIPVMVNMASSSLSLTKSGKSLHKSAFSLDQTNSVNRNSLLMDEDSDDDDEFQIAESEQEPETSKPETDVKRPEEEPAHNIDLSCFSGNLKRNENENARNCWRISDGNNFKVRGKNFGQEKRKIPAGKHLMDLVAVDWFKDSKRIDHVARRKGCAAQVAAEKGLFSMVVNVQVPGSTHYSMVFYFVMKELVPGSLLQRFVDGDDEFRNSRLKLIPLVPKGSWIVRQSVGSTPCLLGKAVDCNYIRGPTYLEIDVDIGSSTVANGVLGLVIGVITSLVVEMAFLVQANTAEEQPERLIGAVRVSHIELSSAIVPNLESE
Protein: SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) (Q9NQ25)
Organism: Homo sapiens (Human)
Function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- CD48 antigen
- SH2 domain-containing protein 1B
- T-cell surface antigen CD2
- SH2 domain-containing protein 1A
- Low affinity immunoglobulin gamma Fc region receptor III-A
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- Low affinity immunoglobulin gamma Fc region receptor III-B
- Natural killer cell receptor 2B4
- NKG2-D type II integral membrane protein
- Signaling lymphocytic activation molecule
Sequence:
MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMVLLCLLLVPLLLSLFVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICPHSGENTEYDTIPHTNRTILKEDPANTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENVI
Protein: Paired box protein Pax-8 (W0S3W1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSNNTGRGHGGLNQLGGMFVNGRPLPEVIRQRIVDMAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIADYKRQNPTMFAWEIRDRLLAEGVCDSDTVPSVSSINRIIRTKVQQPFNLPLDGKGLSPGHILIPSSAVTPPESPQSDSLGSTYSISGLLGIPQPSQEGKRSHDDSDQESCRHSVDSQGSGGVPRKQLRPEHFPPQHLDCGFDRHHYPPDSFSSAAASKTEQTVYPLSLINGSLEDGKTSLSTSSAAIGRNLAAHQGYTVVADPLQPLPLCLKQEMSPEVTSTSPSPNVVANSAFLELQSLQAPVSISSSCSSSNHFPHAFNSFSHHAPVYSQFSSQSLIAGRDMVSSTLPGYPPHIPSSGQTGYSSSAITGMVAGADYSGQTYTHSPYTSYSEAWRFTNSSILGSPYYYSSASRTAPPSTAAYDHL