wanglab/gogpt-training-data huggingface dataset:
Protein: Putative lipoprotein LprJ (O33192)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).
Subcellular location: Cell membrane {ECO:0000255, ECO:0000305|PubMed:12581360}; Single-pass membrane protein {ECO:0000255}. Note=Probably also has a lipid-anchor at the mature N-terminus. Has been suggested to have 2 transmembrane domains (PubMed:12581360), but bioinformatic evidence does not support this. {ECO:0000305}.
Interaction partners:
- Sensor protein KdpD
- Tetratrico peptide repeat group 5 domain-containing protein
- D-glycerol 3-phosphate phosphatase
- Uncharacterized protein
- NAD kinase
- 16S/23S rRNA
Sequence:
MTAHTHDGTRTWRTGRQATTLLALLAGVFGGAASCAAPIQADMMGNAFLTALTNAGIAYDQPATTVALGRSVCPMVVAPGGTFESITSRMAEINGMSRDMASTFTIVAIGTYCPAVIAPLMPNRLQA
Protein: Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1) (P55001)
Organism: Homo sapiens (Human)
Function: Component of the elastin-associated microfibrils.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Fibrillin-1
- Elastin
- Fibrillin-2
- Decorin
- Microfibrillar-associated protein 5
- Microfibril-associated glycoprotein 3
- Microfibrillar-associated protein 1
- Biglycan
- Protein-lysine 6-oxidase
- Lysyl oxidase homolog 1
Sequence:
MRAAYLFLLFLPAGLLAQGQYDLDPLPPFPDHVQYTHYSDQIDNPDYYDYQEVTPRPSEEQFQFQSQQQVQQEVIPAPTPEPGNAELEPTEPGPLDCREEQYPCTRLYSIHRPCKQCLNEVCFYSLRRVYVINKEICVRTVCAHEELLRADLCRDKFSKCGVMASSGLCQSVAASCARSCGSC
Protein: Homeobox protein SIX3 (Sine oculis homeobox homolog 3) (O95343)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q62233, ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Paired box protein Pax-6
- Zinc finger protein ZIC 2
- Protein dispatched homolog 1
- Sonic hedgehog protein
- Homeobox protein OTX2
- Visual system homeobox 2
- Geminin
- Nuclear receptor subfamily 4 group A member 3
- Hepatocyte nuclear factor 3-beta
- Ectonucleoside triphosphate diphosphohydrolase 2
Sequence:
MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV
Protein: Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (Nitric oxide synthase, brain) (Peptidyl-cysteine S-nitrosylase NOS1) (H0VEY0)
Organism: Cavia porcellus (Guinea pig)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004468}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004468}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}.
Interaction partners:
- Nitric oxide synthase 1 adaptor protein
- Sulfite oxidase, mitochondrial
- FAD synthase
- Cytochrome b5 reductase 4
- Cystathionine beta-synthase
- Anamorsin
- Cystathionine gamma-lyase
- Ferredoxin-2, mitochondrial
- Adrenal ferredoxin
- Calmodulin-like protein 4
Sequence:
MEDHVFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGAPTKAVDLSHQPSASKEQAPAVDGATGPGNGPQHAQDNGQESSLLSHTNGLAPRTPSKGPAKKSATVSAQGSREHNELLREIEPVLSLLTSGGNKGAPAKVDMKDTGVQVDRDLDSKSHKALTLGGENDRVLHDLWGDSNAPVVLNNPYSEKEQPPASGRQSPTKNGSPSKCPRFIKVKNWETDVVLTDTLHLKSTLETGCTEHICIGSIMLPPQHTRRPEDVRTKGQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNAARCVGRIQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWNAQLIRYAGYKQPDGSTLGDPANVAFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDSSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPCFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKGPSLPRGDTEVHGLAAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWKDEPRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTVVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPIHHGVCSSWLNRIQADEVVPCFVRGAPSFHLPQNPKVPCILIGPGTGIAPFRSFWQQRQFDIQHKGLSPCPMILVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDVLQEQLAETVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMAQQGRLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
Protein: CAP, isoform I (A1Z866)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLKFCSLRRSKEPAIVAPKVAKSSSLRLKDVPLNDAQLLQVLHAQRERGPLILALSSAKNSVQTCRKCGTPYENRQVVENGTTARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVERA
Protein: ATP synthase subunit J, mitochondrial (ATPase synthase I subunit) (P81450)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:16823961}; Single-pass membrane protein {ECO:0000269|PubMed:16823961}.
Interaction partners:
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit H
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit 4
- ATP synthase protein 8
- ATP synthase subunit a
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit f
- ATP synthase subunit d
- ATP synthase subunit alpha
Sequence:
MLKRFPTPILKVYWPFFVAGAAVYYGMSKAADLSSNTKEFINDPRNPRFAKGGKFVEVD
Protein: ATP-sensitive inward rectifier potassium channel 14 (Inward rectifier K(+) channel Kir2.4) (IRK-4) (Potassium channel, inwardly rectifying subfamily J member 14) (Q9UNX9)
Organism: Homo sapiens (Human)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 5
- Potassium voltage-gated channel subfamily KQT member 2
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 4
- Potassium voltage-gated channel subfamily KQT member 1
- Guanine nucleotide-binding protein G
- ATP-sensitive inward rectifier potassium channel 12
- Inward rectifier potassium channel 4
- Inward rectifier potassium channel 2
- Inward rectifier potassium channel 18
Sequence:
MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSLKSSFPGSLTAFCYENELALSCCQEEDEDDETEEGNGVETEDGAASPRVLTPTLALTLPP
Protein: Histone-lysine N-methyltransferase set1 (EC 2.1.1.354) (Histone H3 lysine 4 methyltransferase) (SET domain-containing protein 1) (Q54HS3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Histone methyltransferase that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. May act to regulate chromatin-mediated events.
Subcellular location: Nucleus {ECO:0000269|PubMed:16469305}. Chromosome {ECO:0000305|PubMed:16469305}.
Interaction partners:
- Retinoblastoma-binding-like protein E
- B30.2/SPRY domain-containing protein
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Histone H3.3 type c
- Histone H3.3 type a
- Histone H3.3 type b
- WD repeat-containing protein 5 homolog
- Histone H4
- Carbohydrate binding domain-containing protein
Sequence:
MENETIVDNSLNNKSNVNNSNNDINNSKSNNNNTNTNYNNNHNNTTTTTTINKTEEKQNDSPKDSEFEFLDELKGVDDQHHVFSSEDESYTNGNKKRKQTDTPLSPNQDLKKRSITSPTTSPTTSTSTSTSTSTSTSTSTIINNNNNNLKDKTKEEIEFIKHIRSQLVKPKFLKDKPNFPLRSSGGNWIFVGKLPSLQSTTTDNTTLMSPNNATTTNGSSSNISTTTTTTTTTTPTTKILYRVNGFLSDNETIDSIEINFGDPRDRYEIERLHSSRINNPFELPCVSFKNPLFIKSNIAKDIGISNEYGGMNDSFEFSNQPPPPSPPPPPPPTLPPPPPPTLPPQHSLEQQSTKQQIFTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQIPKINQQHYSTQPSVLIDDIYDPSNPTEPISPHQDHYPNFIFSKLQRYEHLPTRNPISQYDYRDRPRDWERDRDRDWERDRDWERDRDRERDRDRDRDWERDRDWERDRDWERDRDRDRDWERDRDRDWERDRDRDWERDRERDRDRYDRQTNFSPAPQSTTTSASTSSTTSSTDKNSNNTTSTSVSATTSTTKRKSKFSEPIEPSPFAIQIPRDNIKINGNLINNSSSSSSSGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNSDVKDIKDKLLKQFKIYDPVNVYMDESYWYIDFRSSESRERAIQVLNGSFIDTWKLNVDNKKTNTINEELQKQKQLENDSNNNKPNNFNLLENERSLKEICKLLVATELLSTSSKDISKNFIEAEILKTIKLLDSQRIDPLTQNSTIINNTTNTTTSNINNTSNNTTVTPIVTPKSIISAPTSRDSPRGGRSSSTTTKKPSKLDLNGSGVPPTLKKLDTIKQQQQPQPPLSPLKRPPKSHFYSDSEDDGNNNNDDDDDDDDDEDDDFDQELSPLHSSRDSKKNIKSIIKKKPIYSDDDDDHYHHHNHHHNHHHHHHHDRSEVELYNESDLQVDVLDSDNENQDESDYHKSSDNFGHVELSDDDNEFDSLDTDQDLYDTEENDNGKKSNKRPRKSKFNGKSKKPTTTTSTTTTATKSKGRSKKTTITTPTHNIPVLDEIQSNLDDEDASYVSMVMAADKDIKLLFSTKSEEGFEDSSQEILSTPTRTKPSRNRKERNLPFLDEEDDESFKQLPQPQQKQEKQEKHEHKLKNKELKQKNNEVIINKTEEHFSENLNGDNNNNNDKSENENENENENKNENENDNNNLNTSIDNINGVERRSITGCARSEGYTRSDIQKLFKRKQVAPTGKRGAASSASSGSNSSSSSTAESFETGGNLSKSARSSRFDNRGFGSDPITLASLKSRRKRIKFERSDIHDWGLFAMETISAKDMVIEYIGEVIRQKVADEREKRYVKKGIGSSYLFRVDDDTIIDATFKGNLARFINHCCDPNCIAKVLTIGNQKKIIIYAKRDINIGEEITYDYKFPIEDVKIPCLCKSPKCRQTLN
Protein: Cation-transporting ATPase E1-E2 ATPase (P74512)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362081}. Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Ssr2857 protein
- Slr1507 protein
- ABC transporter
Sequence:
MVQLSPTPASTLTYKDANGQNRTASLTLDVGGMKCAGCVAAVERQLDQLTGVTDSCVNLVTAVAVVRYEPEKIQPQAIAEHLSQRGFPSQIRHGHGAIPATIGEKETRENVNWGLTIALVLLLLSGLGHLSHFGGPMIPFFHHPIFHWSLATLAIAIPGREIFLDGWRGLRFGHANMNTLVALGTGSAYLTSCIAWAWPGLGWECFFDEPVMLLGMLLLGRTLESKARQKAKSALTELLALQPSLARLVGRGEDQGETGIEIPVEQVRVGEWVQVLPGEKIPVDGILVAGKTLVDESLLTGESLPVAKNVDDAVIAGAWNQSGAIIIAATHIGAETTLARIIQLVETAQTQKAPMQRLADQVAGWFAYGVLAIALVTLGFWAMVGQSLFPEMVADTGLSPLLLALKLSVSVLVVACPCALGLATPTAILVGTSLGAEQGILIKGGNILEILQRTTVMAFDKTGTLTQGNLQLTDAVPVADITGIELLTLAASVEQGTRHPLAQGLISSAQGLELLPVENIETEAGQGVQGWYQGDRLLVGNQQWLMEQGVMGEPQWQTAVDQLLDQGKTVIFVARNQQLQGFLALRDTLRPEAKATIAQLKQWGIAPLLLTGDHPAIAQAIAMEVGIEEFQAQMTPQAKVAKIKAMQGFNPVSVIAMVGDGINDAPALAQADVGISLSGATAVAMETADVVLMRSHLSDVLKALTLSRSTVAKIKQNLLWALGYNLLAIPLAAGAFLPSFAIVLTPAIAAAMMASSSIVVVLNALALRYQFSRSLGQDPG
Protein: Ras-related protein RABA5d (AtRABA5d) (Q9SIP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Syntaxin-32
- V-type proton ATPase subunit a1
- Kinesin-like protein KIN-14E
- Membrin-12
- Syntaxin-61
- Vesicle transport v-SNARE 12
- Geranylgeranyl transferase type-2 subunit beta 1
- Vesicle-associated membrane protein 711
- Novel plant SNARE 12
- Syntaxin-43
Sequence:
MSSDDEGGEEYLFKIVIIGDSAVGKSNLLSRYARNEFNAHSKATIGVEFQTQNMEIEGKEVKAQIWDTAGQERFRAVTSAYYRGAVGALVVYDISRRSTFESVGRWLDELKTHSDTTVARMLVGNKCDLESIRAVSVEEGKALAETEGLFFMETSALDSTNVKTAFEMVIRDIYTNISRKQLNSDTYKTELSMKNRVSLVKDDNKSSTQGFGFSCCSSS
Protein: Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) (Q96RJ0)
Organism: Homo sapiens (Human)
Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:11723224, ECO:0000269|PubMed:31399635, ECO:0000269|PubMed:36100653}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:36100653}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118}. Cell membrane {ECO:0000305|PubMed:36100653}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118}. Note=Localizes mainly intracellularly (PubMed:11723224, PubMed:31399635, PubMed:36100653). Partially colocalizes with the endoplasmic reticulum; also found at lower lever at the plasma membrane (PubMed:36100653). {ECO:0000269|PubMed:11723224, ECO:0000269|PubMed:31399635, ECO:0000269|PubMed:36100653}.
Interaction partners:
- Band 4.1-like protein 4B
- Band 4.1-like protein 4A
- Tyrosine-protein phosphatase non-receptor type 4
Sequence:
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
Protein: Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) (Q9Y5S1)
Organism: Homo sapiens (Human)
Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9WTR1}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9WTR1}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:Q9WTR1}.
Interaction partners:
- Transient receptor potential cation channel subfamily M member 7
- Transient receptor potential cation channel subfamily M member 2
- Transient receptor potential cation channel subfamily M member 8
- Insulin-like growth factor 1
- Transient receptor potential cation channel subfamily A member 1
- Transient receptor potential cation channel subfamily M member 4
- Short transient receptor potential channel 1
- Transient receptor potential cation channel subfamily M member 3
- Ankyrin-1
- Transient receptor potential cation channel subfamily M member 5
Sequence:
MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN
Protein: orotate phosphoribosyltransferase (EC 2.4.2.10) (A0A1D8PS11)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Dihydroorotate dehydrogenase
- Orotidine 5'-phosphate decarboxylase
- Allantoinase
- Uncharacterized protein
- tRNA
- Lac1p
- Xut1p
- ribose-phosphate diphosphokinase
- Superoxide dismutase
- ribose-phosphate diphosphokinase
Sequence:
MASYKSSFLQLALDSQALKFGKFTLKSGRESPYFFNLGLFNTGKLLSNLATSYAEAIIASGLKFDILFGPAYKGIPLAAITVAKLAELDPINYGDIGYSFNRKEKKDHGEGGSIVGCSLKDKKILIIDDVITAGTAINEAFEIIGNEKGQVVGCIIALDRQETTATDPTKSATQAVSERYQIPVLSIVNLGEVISILNGKINDEDLKSIEQYRSKYGA
Protein: Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) (P48057)
Organism: Mus cookii (Cook's mouse)
Function: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000250|UniProtKB:P31648}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000250|UniProtKB:P31648}.
Interaction partners:
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWNVAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRCLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYSRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
Protein: Transcription factor Jun (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (Q6NZT5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein c-Fos
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
- Stress-activated protein kinase JNK
- Activating transcription factor 3
- Mitogen-activated protein kinase
- Protein c-Fos
- FBJ murine osteosarcoma viral oncogene homolog B
- Stress-activated protein kinase JNK
- V-fos FBJ murine osteosarcoma viral oncogene homolog Aa
Sequence:
MSTKMETTFYDDSLNSAFSQHDSATFGYNHKALKHNMTLNLSDPAGNLKPHLRAKASDILTSPDVGLLKLASPELERLIIQSSNGMITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHHQHMPNVTSAPQTTINSSMAPVSSIAGGAVYSSAMRADPPVYADLNTFNPAISSSSANPAAMSFPSAPPQLPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERISRLEDKVKTLKSQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Protein: BOC cell adhesion associated, oncogene regulated (BOC protein) (Boc homolog (Mouse), isoform CRA_b) (cDNA FLJ31797 fis, clone NT2RI2008942, weakly similar to NEURAL CELL ADHESION MOLECULE L1) (Q96DN7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLASESAPLPPCHGAVPPHLSHPEAPTIHAASCYS
Protein: Splicing factor, CC1-like protein (F4ILE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cell division cycle 5-like protein
- At2g29210/F16P2.41
- RNA-binding motif protein 25
- Nuclear protein-like
- Pre-mRNA-splicing factor 38
- Ribosome biogenesis protein NSA2 homolog
- Vacuolar protein sorting-associated protein 53 B
- Receptor-like protein kinase At3g21340
- DET1- and DDB1-associated protein 1
- Probable CCR4-associated factor 1 homolog 5
Sequence:
MDFDEYEYLEKTVENPHLENEVGNGGGDEKVKSEGKERSRSSRHRGDKKKERDEDEDGRRSKRSRSHHRSRSRDRERDRHRSSREHRDRDREKDVDKEERNGKDRERDRDKDRDSKGRDHEKDRSRRSRSRSERHRSQEREKSLEIEPKERETKDRDRDRRYTSELVIDFIIYVHWYCLLYNLMGHVPFKIIIVIEGTSRASCVYAYWRKRHKDKKEDKVEPEADPERDQRTVFAYQIALRATERDVYEFFSRAGKVRDVRIIMDRISRRSRGIGYVEFYDTMSVPMAIALSGQPLLGQPVMVKPSEAEKNLVQSTTAAAGAGGMLGPYSGGARRLYVGNLHINMSEDDLRKVFESFGSVELVQVPRDETGLCKGFGFVQFARLEDARNALNLNGQLEIAGRAIKVSAVTDQTEVPEAGQTQTTGDLDDDDGGGLSLNAQSRALLMQKLDRSGTASSTGLTTAASFNGGVSTISSLAAPALVQGSFPAVAGLAGSGIIPGVIPAGFDPIGVPSECLLLKNMFDPSTETEDDFDEDIKEDVKEECSKFGKLNHIFVDKNSVGFVYLRFENAQAAIGAQRALHGRWFAGKMITATYMTTEAYEAKFPESKVV