wanglab/gogpt-training-data huggingface dataset:
Protein: Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (Q9VXW2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Splicing factor 3B subunit 1
- Splicing factor 3A subunit 1
- Splicing factor 3B subunit 5
- Splicing factor 3A subunit 2
- Splicing factor 3B subunit 3
- PHD finger-like domain-containing protein 5A
- Probable small nuclear ribonucleoprotein Sm D1
- Probable U2 small nuclear ribonucleoprotein A'
- LD45152p
- U1 small nuclear ribonucleoprotein A
Sequence:
MSKSSGRDRDRERDRERERERDRERERDRDRERDNRHDSRSRDYDMGKSRNGGGGGAGGGSRNMREDRKRGKDMISDRGKRDDKRRKCSRSKDYEKDNSPHYRRLDKDRDRDRDRDRQREKEREREKEKEREKEKERERDKDRERDRQREKESDSRRAAAAAPLIIPLLSTSCSEEEVEEIDKEEQQRRLEQEMIKRRERIERWRAERKRDTKAAVVAPSLVNSAKKWSLEDESEEDDSNPAPPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSSKNLDTKGSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPKEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRGTYVPQGKNPPDGERKLYLAIESCSELAVQKAKREITRLIKEELLKLSSAHHVFNKGRYKVV
Protein: Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) (Q61165)
Organism: Mus musculus (Mouse)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P19634}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19634}. Basolateral cell membrane {ECO:0000250|UniProtKB:P48762}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19634}. Note=Localized basolaterally in every epithelial cell, except in the choroid plexus where SLC9A1 is expressed luminally. {ECO:0000269|PubMed:19369449}.
Interaction partners:
- Ezrin
- Moesin
- Calcineurin B homologous protein 1
- Radixin
- Rho-associated protein kinase 1
- Mitogen-activated protein kinase 3
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Rho-associated protein kinase 2
- Mitogen-activated protein kinase 1
Sequence:
MMLRWSGVWGFHPPRIFPSLLVVVALVGLLPVLRSHGLQHSPTASTIRGSEPPRERSIGDVTTAPSEPLHRPDDHNLTNLIIEHGGKPSRKAFPVLDIDYPHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKAVTSDRILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTLSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLNRGPRVTPEEEEEDEDGIIMIRSKEPSSPGTDDVFTPGSSDSPSSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
Protein: Transcriptional dual regulator GltC (HTH-type transcriptional regulator GltC) (P20668)
Organism: Bacillus subtilis (strain 168)
Function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression.
Interaction partners:
- Glutamate synthase large chain
- Catabolic NAD-specific glutamate dehydrogenase RocG
- Chromosomal replication initiator protein DnaA
- HTH-type transcriptional regulator TnrA
- Glutamate synthase small chain
- Glutamine synthetase
Sequence:
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKILFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ
Protein: GEM-like protein 1 (Forming homology-interacting protein 1) (FH-interacting protein 1) (Q9SE96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 30-kDa cleavage and polyadenylation specificity factor 30
- Protein CLP1 homolog
- Putative defensin-like protein 72
- Germin-like protein subfamily 1 member 20
- Cleavage stimulation factor subunit 77
- F-box protein SKP2B
- Protein VASCULAR ASSOCIATED DEATH 1
- DNA replication licensing factor MCM6
Sequence:
MSGQENHDHGRISSTPAAASEPSKAAAHSSDYAPYPKLDPTDVTPPPPQPIPTGAAATTMPAESNPYVSPSPAPRNTMDSVKDTLGKWGKMAADATKKAEDLAGNFWQHLKTGPSVADAAVSRIAQGTKILAEGGYEKVFKQTFDCLPDEKLLKTYACYLSTSAGPVLGVMYLSTHKLAFSSDNPLSYKEGEQTLWSYYKVVLPANQLKAVNPSTSRVNTSDKYIQVISIDNHEFWFMGFVTYESAVKSLQEAVQSHGP
Protein: mRNA guanylyltransferase (EC 2.7.7.50) (F4IYM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- mRNA guanylyltransferase
- mRNA guanylyltransferase
- Inositol diphosphatase DSP1
- mRNA cap guanine-N
- Pentatricopeptide repeat-containing protein At5g16640
- Triphosphate tunnel metalloenzyme 3
- Pentatricopeptide repeat-containing protein At1g62910
- Nuclear cap-binding protein subunit 2
- Inositol diphosphatase DSP4
- DNA-directed RNA polymerase II subunit 4
Sequence:
MVATMDLNASPQPEEDDEPYVRHLEDYSSRDERIESAVEIARREREERKKRMRYDKPTHNSQPVFRDQYYQNRNTKAYDRYKIPQGWLDCPPSGNEIGFLVPSKVPLNESYNNHVPPGSRYSFKQVIHNQRIAGRKLGLVIDLTNTTRYYSTTDLKKEGIKHVKIACKGRDAVPDNVSVNAFVNEVNQFVLNLKHSKKYILVHCTHGHNRTGFMIVHYLMRSGPMNVTQALKIFSDARPPGIYKPDYIDALYSFYHEIKPESVICPSTPEWKRSTELDLNGEALPDDEDDDGGPAGPVQGFQEESHQVDVKMSNDDVLGDEIPPDQEEGYRQFFYRMLSLNIGGRGCSQFPGSHPVSLNRENLQLLRQRYYYATWKADGTRYMMLLTTDGCYIVDRSFRFRRVQMRFPFRHPTEGISDKVHHFTLLDGEMIIDTLPDKQKQERRYLIYDMVAINGQSVVERPFYERWKMLEKEVIDPRNHEKARSHIYRYDLEPFRVRRKDFWLLSAVEKVLKGFIPSLSHEADGLIFQGWDDPYVPRTHEGLLKWKYPEMNSVDFLYEQDESGRGMLSLFERGKKKHMDGNSVVFRDDSDPAEYSGKIVECSWDQDEKVWVSMRVRVDKSTPNDINTFRKVMRSIKDNITEEVLLQEIREIIRLPMYADRIQMDSKAARRR
Protein: cDNA FLJ55508, highly similar to Sad1/unc-84-like protein 2 (B4E2A6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004540}.
Interaction partners:
Sequence:
MVSPPSAGQRLRGVPVWAAGAFRFSSGEESTSHLIMSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLWMVATSPGRLFRLLYWWAGSTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
Protein: Chlorophyll a-b binding protein CP29.3, chloroplastic (LHCB4.3) (LHCII protein 4.3) (Q9S7W1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular location: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Interaction partners:
- Chlorophyll a-b binding protein CP26, chloroplastic
- Photosystem II CP43 reaction center protein
- Photosystem II CP47 reaction center protein
- Photosystem II D2 protein
- Photosystem II protein D1
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem II reaction center protein H
- Chlorophyll a-b binding protein 1, chloroplastic
- Photosystem II reaction center protein J
Sequence:
MATTTAAAASGIFGIRIQDPRPGTGRVQARFGFSFGKKKPAPPPKKSRQVQDDGDRLVWFPGANPPEWLDGSMIGDRGFDPFGLGKPAEYLQYDFDGLDQNLAKNVAGDIIGIIQESSEIKPTPFQPYTEVFGIQRFRECELIHGRWAMLGTLGAIAVEALTGIAWQDAGKVELVEGSSYLGQPLPFSLTTLIWIEVLVVGYIEFQRNSELDPEKRIYPGGYFDPLGLAADPEKLDTLKLAEIKHSRLAMVAFLIFALQAAFTGKGPVSFLATFNN
Protein: DNA-binding protein HU-alpha (HU-2) (NS2) (P0ACF0)
Organism: Escherichia coli (strain K12)
Function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}.
Interaction partners:
- DNA-binding protein HU-beta
- Chromosomal replication initiator protein DnaA
- DNA-binding protein H-NS
- Cold shock-like protein CspC
- Integration host factor subunit alpha
- DNA-binding protein Fis
- Uncharacterized protein YjaH
- Integration host factor subunit beta
- DNA primase
Sequence:
MNKTQLIDVIAEKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTGRNPQTGKEIKIAAANVPAFVSGKALKDAVK
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (Q8MQC8)
Organism: Caenorhabditis elegans
Interaction partners:
- Acyl-CoA synthetase 7
Sequence:
MSLKKFILFKLILLFPDIQSLKVIETSYGRVRGITEWSDDNNHKYMFKSVPFAKPPIGKLRFAPPQYPDSWSGVLDASKYSPACLSNSSTTSTPQEHVSEDCLYINIFTSEKCLRSKCAVIVYFHGGAYNGDSATMFPDNFILERYVAEDVILAIPGVRLGVFGQLYFGPSALLTENLFMFDAVQALDFVHNEIPNFGGDPKQVTIMGHSSGGTLVEALGFSNSVDPDLKLFQQIIVLSGTGMFGFYDLLVDNSFIISEKLGCFNGTQEERTDANIAEILECMRQIDGHEIVGMQKHMEDVYKLTFKSLLRGAPFMELNGKIEKFRNSTSPRNAIFGTTEYEFRNEVERYLYITTTFLDFENPVAVAQHFDDELMQNMDTMINGDAVSIFVSAAAFSSAMANAGADVYLFETRQWPYSFHVSDMQYFIGIHREVLHTHDMDILDSFYSKLLVNFTKTGAPSPEWNSLEPEKMNYLELRVDTRNGKGPVMLEGYHDKEVSFWYGDMMDYDRNITKMRQSKGLPRENQGVESQLKYWSSIVEPRTTAHANNATQENISTSTNVLFTSTAQYISREFKNSTPILQQWWFYLIIALVVMIFVLIFISLRKPRREEEVPLLS
Protein: Mbnl2b protein (Muscleblind-like protein 2 isoform X8) (Muscleblind-like-splicing regulator 2) (B7ZUV4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALNIASIRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCTRENCKYLHPPAHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMIPGTTMQPVPTFPVSQGLGSNPGLSYAPYLTPMSHGMGLVPTEMLPSTPVIVPGSPPVSVPSSSSTQKLLRTDKLEVCREFQRGNCARGETDCRFAHPSDSPMIDTSDNTVTVCMDYIKSRCSREKCKYFHPPAHLQAKIKAAQHQANQTAVAAQAAAAAMTQSTAKAMKRPLEASVDLAFPHGVLQPLPKRPALEKSNGASTLFNPSVLHYQQALASAQLQQPTAAFFPTATTPATSVPYATTAPANQIILK
Protein: Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-) (Q14249)
Organism: Homo sapiens (Human)
Function: Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA. The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified. Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response. GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation. Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:33473107}.
Interaction partners:
- Apoptosis-inducing factor 1, mitochondrial
- Cytochrome c
- Diablo IAP-binding mitochondrial protein
- 28S rRNA
- TBC1 domain family member 13
- Zinc phosphodiesterase ELAC protein 2
- Serine protease HTRA2, mitochondrial
- Intelectin-2
- Flap endonuclease 1
- Kynurenine--oxoglutarate transaminase 1
Sequence:
MRALRAGLTLASGAGLGAVVEGWRRRREDARAAPGLLGRLPVLPVAAAAELPPVPGGPRGPGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
Protein: Paired box 5 (Paired box protein Pax-5) (F1QGF8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcription factor 3a.
- Transcription factor COE4
- Runt-related transcription factor
- V-ets avian erythroblastosis virus E26 oncogene homolog 1.
- CD79b molecule, immunoglobulin-associated beta
- CD79a molecule, immunoglobulin-associated alpha.
- IKAROS family zinc finger 1
Sequence:
MDLDQKGPSLRIGRSGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVDKIADYKRQNPTMFAWEIRDRLLAERVCDNDSVPSVSSINRIIRTKVQQPPGQSGAVSAHNLASTVAVTQVSAVTSDAAGSSYSISGILGISSPADASKRKRDDPLQDSPLANGHSHSGRDFLRKQMRGELFTPQQLETTDYSAMASLAGGLEEMKNSLANQTGAELGSTVAGPQSYPLVSGRDLASTTLPGYPPHVPPTGQGSYSTPSLTGMVPGGDFSGSPYSHPQYSTYNESWRFANPSLLVFQQEYGSLLGSERAASSGLFPGQTPQPTGSPYYYSAATRGAGTAATATASAYDRH
Protein: RE60102p (Q5BIH3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFQRSYSKVWWGSEQSSLTSGGFYSSFSGGSSTSSTSNYPQRQPASLGPLGNLSCIQEVEDEQNSSKLSWHKHDSPGSLRSQDSGFSDNEESHQLQHQQNLSPPSPQSDKQQTPAATPTSVHSVATPPTVVRRVGNSSFYSPLISVTRRISFTSGQITPKTRSGDEDAEDAELEASRSRLFEQLDSMKLDDGEAEAEEDSPPRPAIRRRRRLMRKPMPEPEAASASEEEEVVIAPPPPPPYNNETVYLGEAPPPYNNETVTFGATEQDESLQQQPSPLRVRSLRFTASTSTPKSGSKIAKRGKKHPEPVASWMSEQRWAGEPEVMCTLQHKSIAQEAYKNYTITTSAVCKLVRQLQQQALSLQVHFERSERVLSGLQASSLPEALAGATQLLSHLDDFTATLERRGVFFNDAKIERRRYEQHLEQIRTVSKDTRYSLERQHYINLESLLDDVQLLKRHTLITLRLIFERLVRVLVISIEQSQCDLLLRANKYGSHLDEH
Protein: Envelope glycoprotein B (gB) (F5HB53)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). {ECO:0000255|HAMAP-Rule:MF_04032}.
Interaction partners:
Sequence:
MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGTDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNIVAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTHSTRYVTVKDQWHSRGSTWLYRETCNLNCMVTITTARSKYPYHFFATSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNRTKRSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDIDPLENTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPLPPYLKGLDDLMSGLGAAGKAVGVAIGAVGGAVASVVEGVATFLKNPFGAFTIILVAIAVVIITYLIYTRQRRLCTQPLQNLFPYLVSADGTTVTSGSTKDTSLQAPPSYEESVYNSGRKGPGPPSSDASTAAPPYTNEQAYQMLLALARLDAEQRAQQNGTDSLDGRTGTQDKGQKPNLLDRLRHRKNGYRHLKDSDEEENV
Protein: Uncharacterized protein (Q385M6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Trafficking protein particle complex subunit
- Rab GDP dissociation inhibitor
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Transport protein particle
- Uncharacterized protein
- Transport protein particle
- Trafficking protein particle complex subunit
- Vesicle tethering protein Uso1/P115-like head domain-containing protein
- Geranylgeranyl transferase type-2 subunit beta
Sequence:
MTQAVEMAQCDRVVIFLDVDGVLLPVPRFTFGGGDLSPQCVGYLLKIVDACGTAEKVTIILSSTWRNFPAQVQRLNNFFAKTVGDAVPPIAGGTPNGTPKVTVVSYYADDPSEQRLVRDRVDEIKRWINTNMREHPEAVGGRWFAIDDMQLDVDERMRGHFLKTTTEIGLVEDDIERAREIIAAFPPPEEAARNAAAALVDPALKDEEIDILETRCRNLSETAEQLKNDLAEAHEEIRRLQGERTVRERDMKELTRRFEDVSYRLAQYDFSKKNAVLRSAIEALASKTGKERRELEDRIKTLVNLLRHKKELEKMAAKNRKKEGQAQVKN
Protein: Antitoxin MazE (P0AE72)
Organism: Escherichia coli (strain K12)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their own transcription. There are 3 operators to which MazE binds. MazE has higher affinity for promoter DNA in the presence of MazF.
Interaction partners:
- Endoribonuclease toxin MazF
- Endoribonuclease toxin ChpB
- Antitoxin ChpS
- Nucleoside triphosphate pyrophosphohydrolase
- mRNA interferase toxin YafQ
- mRNA interferase toxin MqsR
- Antitoxin DinJ
- mRNA interferase toxin RelE
- Antitoxin YefM
- Antitoxin MqsA
Sequence:
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKEVW
Protein: DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (P54358)
Organism: Drosophila melanogaster (Fruit fly)
Function: As the catalytic component of the DNA polymerase delta complex, plays a crucial role in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Required at the nucleus of rapidly dividing embryonic cells to activate genome replication during the earliest cell cycles. Likely to require the presence of accessory proteins PolD2 and PolD3 for full activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:31100062}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31100062}. Note=In embryos, accumulates in the nucleus during interphase but disperses into the nucleoplasm at the onset of mitosis. {ECO:0000269|PubMed:31100062}.
Interaction partners:
- DNA polymerase delta subunit 3
- DNA polymerase delta subunit 2
- Flap endonuclease 1
- DNA primase large subunit
- DNA primase small subunit
- DNA polymerase epsilon catalytic subunit 1
- DNA polymerase alpha subunit B
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon subunit 2
- DNA replication licensing factor Mcm5
Sequence:
MDGKRKFNGTSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPPPELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPVVRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSDEQYEGATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAHVELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSVPIDATYYLEQQLSKPLLRIFEPILGDNAESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHCEPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDLDNQEKRVLRFGLAEW
Protein: Beta-glucosidase 12 (AtBGLU12) (EC 3.2.1.21) (Q9FH03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Endoglucanase 9
- Endoglucanase 3
- Putative beta-glucosidase 2
- Beta-glucosidase 13
- Beta-glucosidase 7
Sequence:
MRTIYLSLLVFIIVLALNEVMAKKHSSTPKLRRSDFPEDFIFGAATSAYQVEGAAHEDGRGPSIWDTFSEKYPEKIKDGSNGSIASDSYHLYKEDVGLLHQIGFDAYRFSISWSRILPRENLKGGINQAGIDYYNNLINELLSKGIKPFATIFHWDTPQSLEDAYGGFLGAEIVNDFRDYADICFKNFGDRVKHWMTLNEPLTVVQQGYVAGVMAPGRCSKFTNPNCTAGNGATEPYIVGHNLILAHGEAVKVYREKYKASQKGQVGIALNAGWNLPYSESAEDRLAAARAMAFTFDYFMEPLVTGKYPIDMVNYVKGGRLPTFTAKQSKMLKGSYDFIGRNYYSSSYAKDVPCSSENVTLFSDPCASVTGEREGVPIGPKAASDWLLIYPKGIRDLLLYAKYKFKDPVMYITENGRDEASTGKIDLKDSERIDYYAQHLKMVQDAISIGANVKGFFAWSLLDNFEWATGYAVRFGLVYVDFNGGRKRYPKKSAKWFKKLLNEKKKN
Protein: BZIP domain-containing protein (G5EAX9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- HapE
- Calmodulin, putative
- Transcription factor HapC
- Tropomyosin TpmA
- Transcriptional activator HAP2
- GATA-type transcription factor sreA
- Calmodulin
- Calmodulin
Sequence:
MAAQPALAIAPSAAPLAPALVAKPTVSPSPGPGTPGSVTSKEWIIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVSELEDQIKCIEDDHEIHVATFKEQIANLSREVEQCRTEMGWWRDRCHALEKEVSVERAARETLVKELRSSLPEKNTSGTDAVPLPPRSSRSSRMELEKSSPVDRRSELGEEVPLGCNRCSTSHCQCIEDAFGMPPIEMNRAPEPKIKPEPEEMEIDFTTRFAAPHHEEDTAASPVASPPVDPCGFCQDGTPCICAEMAAQEEERRRNSTFESNRLAPIQNISQFTPPPSDSDVRSDNVTLPPISQATAANPCANGPGTCAACLSDPRRTLFCKTLAASRSASGTPSGCCGGKGRDGGCCQSQSRTSAPRRSNTDRSATPLTLSCADAFTTLSRHPNFSRASDELASWLPKLHTLPNPRDVSQTTPASRAAMEVEAASVMGVLRYFDRRFADK