wanglab/gogpt-training-data huggingface dataset:
Protein: UDP-glucuronosyltransferase (EC 2.4.1.17) (B0S5H4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
Interaction partners:
- Cytochrome P450 1A
- Aldehyde oxidase 6
- Xanthine dehydrogenase/oxidase
- Aromatase
- Cytochrome P450, family 3, subfamily A, polypeptide 65
Sequence:
MLLHPQISVLVAFIWSLPSLSLAGKILVYPVDGSHWLNMNILLQELHQRGHKLTVVRSANSWYIPENATHYTSITIQVNHLSSLEDPKYMASFLKRNIDIQRGKGSIWSFLALQKEIITLLEESHRSTAEMVRVVLEDEKLIKTLKESKYDLMLTDPGFAGGVILGAYLGLPMVFNVRWITNAEGHFAIAPSPLSYIPTIGSRVTDKMSFANKLKNIMHFGIGQYIDHMLTRPLYQGVISKYIDPNTNVYALIQGADLWLMRVDFVFEFPRPTMPNVVYIGGFQCKPSKPLPDELNKFVESSGEHGVVIMSLGTLLGSLVPDISEIVASAFAQLPQKVIWRHVGEKPSTLGNNTLVVDWLPQNDLLGHPKTKAFVTHGGTNGIYEAIYHGVPMLGLPLIFDQFDNIIRLEARGVARMLDVATLDVDILTQALKDILDEKQSYQKNMRKMSSLHRDTPLKPLDSAIFWLEFVMRHKGAAHLRTESYKLPWYSYHCLDVLALIMSLCTAAGLLLILISRALLRACVRKIKAKKE
Protein: Peroxisome biogenesis protein 16 (Peroxin-16) (AtPEX16) (AtPex16p) (Protein SHRUNKEN SEED 1) (Q8S8S1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the formation of peroxisomes, lipid bodies and protein bodies.
Subcellular location: Peroxisome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Moves through an intermediate compartment from endoplasmic reticulum to pre-existing peroxisomes. {ECO:0000269|PubMed:15173561, ECO:0000269|PubMed:16040658, ECO:0000269|PubMed:17431024}.
Interaction partners:
- Peroxisome biogenesis protein 19-1
- Peroxisome biogenesis protein 12
- Peroxisome biogenesis protein 19-2
- Peroxisomal membrane protein PEX14
- Peroxisome biogenesis protein 3-2
- Peroxisomal ATPase PEX6
- Peroxisome biogenesis protein 5
- Peroxisome biogenesis protein 7
- Peroxisome biogenesis factor 10
- Protein transport protein SEC16B homolog
Sequence:
MEAYKQWVWRNREYVQSFGSFANGLTWLLPEKFSASEIGPEAVTAFLGIFSTINEHIIENAPTPRGHVGSSGNDPSLSYPLLIAILKDLETVVEVAAEHFYGDKKWNYIILTEAMKAVIRLALFRNSGYKMLLQGGETPNEEKDSNQSESQNRAGNSGRNLGPHGLGNQNHHNPWNLEGRAMSALSSFGQNARTTTSSTPGWSRRIQHQQAVIEPPMIKERRRTMSELLTEKGVNGALFAIGEVLYITRPLIYVLFIRKYGVRSWIPWAISLSVDTLGMGLLANSKWWGEKSKQVHFSGPEKDELRRRKLIWALYLMRDPFFTKYTRQKLESSQKKLELIPLIGFLTEKIVELLEGAQSRYTYISGS
Protein: Exosome complex component RRP45B (Protein ECERIFERUM 7) (RNA-processing protein CER7) (RRP45 homolog B) (Ribosomal RNA-processing protein 45B) (Q9M209)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable 3'->5' exoribonuclease involved in the regulation of cuticular wax biosynthesis by controlling the expression of CER3. May act by degrading a specific mRNA species encoding a negative regulator of CER3 transcription. Can perform exosomal functions and complement the yeast rrp45 null mutant.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17351114}. Nucleus {ECO:0000269|PubMed:17351114}. Note=Excluded from the nucleolus.
Interaction partners:
- Exosome complex component RRP41 homolog
- Exosome complex component RRP4 homolog
- Exosome complex exonuclease RRP46 homolog
- Ribosomal RNA-processing protein 42
- Ribosomal RNA-processing protein 43
- Protein RRP6-like 2
- Protein RRP6-like 1
- Nuclear nucleic acid-binding protein C1D
- Exosome complex component RRP41-like
- Exosome complex exonuclease RRP44 homolog A
Sequence:
MEGRLANMWRLTVNESKFVETALQSELRVDGRGLYDYRKLTIKFGKEYGSSEVQLGQTHVMGFVTAQLVQPYKDRPNEGSLSIFTEFSPMADPSFEPGRPGESAVELGRIIDRGLRESRAVDTESLCVLAGKMVWSVRIDLHILDNGGNLVDAANIAALAALMTFRRPDCTVGGENGQEVIIHPLEEREPLPLIIHHLPIAFTFGFFNKGNIVVMDPTYVEEAVMCGRMTVTVNANGDICAIQKPGEEGVNQSVILHCLRLASSRAAATTKIIREEVEAYNCERSLQKVKRHPTLAKSEVSGPTVAVKEEHRKSSDQERAAEISREHVERLKLSTEEVRSSKEEEAANFKGGPSNWDPYSEAMDVDSLKVSLASRGDPVTKSSSTKKMNGSGNAQKVGVEISVEEVTGELGKKDTKHKDGEMTLKDAVKPKKKRKNKS
Protein: Katanin, putative (Q57V58)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}.
Interaction partners:
- Vta1/callose synthase N-terminal domain-containing protein
- SNF-7-like protein, putative
- Vesicular protein trafficking mediator, putative
- Uncharacterized protein
- Charged multivesicular body protein 6
- Uncharacterized protein
- Uncharacterized protein
- IST1 homolog
- Vacuolar transport protein 4A, putative
- Vacuolar protein sorting-associated protein 28 homolog
Sequence:
MSVDFTSKAVELFKKAARHDEQGEYREAYHWYMEAIEVFITAIKYETKNVTKRDLLRKKTMEITERAEKIKEYLENCDANRSGGQASSAVGQKTASSAKKAKEDEEDDKRLKSGLDNAIIRVKPNVQWSQIAGLEAAKEALKEAVILPVRFPQLFTGNRKPWKGILLYGPPGTGKSYLAKAVATEADGTFLSVSSADLMSRWLGDSEKLVRNLFEKAREAYREGGKPAIIFIDEIDSLCSARSDGENDASRRIKTEFLVQMQGVGHDDEGVLVLGATNIPWALDSAVRRRFERRIYIPLPQAHARCQMIKIHLGDTQHSLTDEDCNALAKMTEMYSGSDISIVVRNAMMECVRSVQLATHFKRVTGPDPKDPTRTVNDRLVPCSPGDPNAIPMTMNDITESEKLMPLPVTMQDFIKALRTARPSVSSEDITQHVKFTEEFGQEG
Protein: Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Mesh1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) (Q9VAM9)
Organism: Drosophila melanogaster (Fruit fly)
Function: ppGpp hydrolyzing enzyme involved in starvation response.
Interaction partners:
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS9m
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase
- Large ribosomal subunit protein uL11m
- FI21821p1
- Nucleoside diphosphate kinase-like domain-containing protein
- Guanylate kinase
- Large ribosomal subunit protein uL11
Sequence:
MATYPSAKFMECLQYAAFKHRQQRRKDPQETPYVNHVINVSTILSVEACITDEGVLMAALLHDVVEDTDASFEDVEKLFGPDVCGLVREVTDDKSLEKQERKRLQIENAAKSSCRAKLIKLADKLDNLRDLQVNTPTGWTQERRDQYFVWAKKVVDNLRGTNANLELKLDEIFRQRGLL
Protein: Ubiquitin-conjugating enzyme E2-18 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 11) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (P52492)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins.
Interaction partners:
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit CDC16
- Anaphase-promoting complex subunit 4
- Ubiquitin-activating enzyme E1 1
- Anaphase-promoting complex subunit CDC27
- Anaphase-promoting complex subunit CDC23
- Anaphase-promoting complex subunit 5
- APC/C activator protein CDC20
- Meiosis-specific APC/C activator protein AMA1
Sequence:
MAVEEGGCVTKRLQNELLQLLSSTTESISAFPVDDNDLTYWVGYITGPKDTPYSGLKFKVSLKFPQNYPFHPPMIKFLSPMWHPNVDKSGNICLDILKEKWSAVYNVETILLSLQSLLGEPNNRSPLNAVAAELWDADMEEYRKKVLACYEEIDDY
Protein: CDPK-related kinase 4 (AtCRK4) (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase CRK4) (Q9FIM9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular location: Cell membrane {ECO:0000305|PubMed:17644812}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- Probable cysteine protease RDL5
- 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic
- Expressed protein
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
Sequence:
MGHCYSRNISAVEDDEIPTGNGEVSNQPSQNHRHASIPQSPVASGTPEVNSYNISPFQSPLPAGVAPSPARTPGRKFKWPFPPPSPAKPIMAALRRRRGAPPQPRDEPIPEDSEDVVDHGGDSGGGERLDKNFGFGKNFEGKYELGKEVGRGHFGHTCWAKAKKGKMKNQTVAVKIISKAKMTSTLSIEDVRREVKLLKALSGHRHMVKFYDVYEDADNVFVVMELCEGGELLDRILARGGRYPEVDAKRILVQILSATAFFHLQGVVHRDLKPENFLFTSRNEDAILKVIDFGLSDFIRYDQRLNDVVGSAYYVAPEVLHRSYSTEADMWSIGVISYILLCGSRPFYGRTESAIFRCVLRANPNFEDMPWPSISPTAKDFVKRLLNKDHRKRMTAAQALAHPWLRDENPGLLLDFSVYKLVKSYIRASPFRRSALKALSKAIPDEELVFLKAQFMLLDPKDGGLSLNCFTMALTRYATDAMMESRLPDILNTMQPLAQKKLDFEEFCAAAVSVYQLEALEEWEQIATSAFEHFEHEGNRIISVQELAGEMSVGPSAYPLLKDWIRSSDGKLSFLGYAKFLHGVTVRSSSSRPR
Protein: Phospholipase D B (EC 3.1.4.4) (Phosphatase D1) (PLD 1) (Q54WR4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization. Plays an important role in cell migration by localizing along the anterior cell membrane. Overexpression leads to the inability to aggregate even at higher cell density. Also known as a negative regulator of quorum sensing.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:18164290}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18164290}. Note=In migrating cells, localized at the protruding regions of pseudopodia.
Interaction partners:
- Phospholipase D A
- Probable phosphatidate cytidylyltransferase
- Phosphatidylserine decarboxylase proenzyme 2
- phosphatidylserine decarboxylase
- phosphatidylserine decarboxylase
- PA-phosphatase related-family protein DDB_G0284367
- phosphatidate phosphatase
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 3
- Phospholipase D C
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 1
Sequence:
MNLSQEHAINQNLHKNQKNEEKIEKKTINKDGRGQMNYDGEEGQGEKSRFQKMVENEKIEEPQQKDENIPNTDVIERKEVGVIERINSEDVPILMTDNATDYKVLQHNLKKGKVSKKSKEQIEQISKQEENDMLEYLKNYKSNEEFTIQLEDLLSFETYFSRDELHLLYREFKTISKSGMFMSKEDFISKLTPFSRNADLTISLMNAIDRNGDQKIAFPEFVQALSIMCRGTKKERLRFTFEICDFNGDSLVSRDEVYSTVKAISDIFSKFGYSKDKFGDPSEAVDSIFSSGLTTNGIYLHNKKELTLNEFLERGELNPDLSKCFGMFDYFYLKFIGQIDLLFKDKEINMNGQLTKIKPKTIFNFNISHRRTLSLRDGFLIVYKKKKFKHDEDKPSKVIFLPGSTVKVVVGSQPSKKKKFLSKKFHNYYGFRVTKGNYNRFFLMENRDEALNWVNAIRFHSRQGFRFQSFSKVRSNISVEWFINGSSYYNELAETIRRAKHEIFITGWWVSPYVYLQRDNGIENMEKSRLDRILTEKAKEGVKVYVLMWNETNLGVQLGSRHAKNWLEGCHSNIHVIRHPKRYPLSWSHHQKNAIIDQQIAFVGGIDICLMRYETSKFQLTDDQGKRFPGKDYGNLLGTVIRTGDPKKDQFNRRECPRMPWHDVHTKIVGPSAKDVASNFIQRWNHAIYVERSNRFQPILVPKNYTGLPSDDAKPDKWKNLVSNIRKGFSHVSYGREKPTHYQRAGDNPKVRSHTRQGAFGLQSDQIDNKIDKQKNNSTNSENSENSYSEFDEEDEEGNQEEEDEDEFDEFEKDENQKQENSKIPFNNKPSDAGGLKSKNYKNNNNNNIIESLKDEESFELPGTPKIDLNNDKLLKSIYHLSSNMSENSCVVQMVRSICPWSAGTDVEDSCYKAYLGLIKNAQHFIYIQNLFFISSCGSKLPKNRIALAILNRVRRAITLKEKFRVIIMVPISPSGDLALASSRMIIGWTNRTISQGGQSILELLKNEFPDVDLDQYISFNSIRQWEANGDRIFTEQIYVHSKVLIVDDRVAVIGSCNINDRSMMGSRDSELAVVVSDQSKLLITMNGKPFKVGKFPHTLRVGLWKTHLNLTDSEISSIIDPITDNAFINIWRKTARNNSIIYKEVFGDCILENQRRLGIVQKKYIPKTNELIVQLSQIQGVLIEYPLDMFCESNLFNEQVGIFTAESYVDVSIFT
Protein: CD209 antigen-like protein D (DC-SIGN-related protein 3) (DC-SIGNR3) (CD antigen CD209) (Q91ZW8)
Organism: Mus musculus (Mouse)
Function: Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Lymphocyte-specific protein 1
- CD209 antigen-like protein E
- Scavenger receptor cysteine-rich type 1 protein M130
- Intercellular adhesion molecule 2
- Alpha-
Sequence:
MSDSMESKTQQVVIPEDEECLMSGTRYSDISSRLQTKFGIKSLAEYTKQSRNPLVLQLLSFLFLAGLLLIILILVSKVPSSEVQNKIYQELMQLKAEVHDGLCQPCARDWTFFNGSCYFFSKSQRNWHNSTTACQELGAQLVIIETDEEQTFLQQTSKARGPTWMGLSDMHNEATWHWVDGSPLSPSFTRYWNRGEPNNVGDEDCAEFSGDGWNDLSCDKLLFWICKKVSTSSCTTK
Protein: LOB domain-containing protein 18 (ASYMMETRIC LEAVES 2-like protein 20) (AS2-like protein 20) (O22131)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the positive regulation of tracheary element (TE) differentiation. Involved in a positive feedback loop that maintains or promotes NAC030/VND7 expression that regulates TE differentiation-related genes. Functions in the initiation and emergence of lateral roots, in conjunction with LBD16, downstream of ARF7 and ARF19. Transcriptional activator that directly regulates EXPA14, a gene encoding a cell wall-loosening factor that promotes lateral root emergence. Activates EXPA14 by directly binding to a specific region of its promoter. Transcriptional activator that directly regulates EXPA17, a gene encoding a cell wall-loosening factor that promotes lateral root emergence. Acts downstream of the auxin influx carriers AUX1 and LAX1 in the regulation of lateral root initiation and development.
Subcellular location: Nucleus {ECO:0000269|PubMed:19088331}.
Interaction partners:
- Expansin-A14
- Auxin response factor 19
- Auxin response factor 7
- Putative expansin-A17
- Transcription factor E2FA
- Ethylene-responsive transcription factor ERF086
- NAC domain-containing protein 30
- Auxin transporter-like protein 3
- Auxin transporter protein 1
- Auxin-responsive protein IAA14
Sequence:
MSGGGNTITAVGGGGGGCGGGGSSGGGGSSGGGGGGPCGACKFLRRKCVPGCIFAPYFDSEQGSAYFAAVHKVFGASNVSKLLLHIPVHRRSDAVVTICYEAQARIRDPIYGCVAHIFALQQQVVNLQAEVSYLQAHLASLELPQPQTRPQPMPQPQPLFFTPPPPLAITDLPASVSPLPSTYDLASIFDQTTSSSAWATQQRRFIDPRHQYGVSSSSSSVAVGLGGENSHDLQALAHELLHRQGSPPPAATDHSPSRTMSR
Protein: Serine/threonine-protein kinase KSP1 (EC 2.7.11.1) (P38691)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May act on PRP20.
Subcellular location: Nucleus.
Interaction partners:
- Target of rapamycin complex 1 subunit KOG1
- Cyclin-dependent protein kinase PHO85
- Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
Sequence:
MTLDYEIYKEGGILNNRYQKIEDISEGSYGYVSLAKDVREKRLVAVKYIFKLEDDGQYDGPQDDENDCDSSDCDDDEDTKVDTDRHENENGNASSNNGSSREKKHNLYKHKKSLISSKVKSRLSNNICLEAMYEVDIQTKIGRHQNIAALLDFFDSYIIMEYCSGGDLYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLATTDKTSMDRNVGSERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIVFHKNPFSIANQSDKSFCYFAANREALFDVFSTMAYDFFQVLRYSLTIDPANRDLKMMRTELQNLSEYTLDDEYYNNLDEGYEETMIDGLPPQPVPPSSAPVSLPTPISSSNKQHMPEFKKDFNFNNVNERKRSDVSQNQNVASGFFKKPSTQQQKFFNQGYNTTLSTHERAKSAPKFKFKKRNKYGRTDNQFSKPVNIEDRKKSKILKKSRKPLGIPTPNTHMNNFFHDYKARDEFNTRDFFTPPSVQHRYMEGFSNNNNKQYRQNRNYNNNNNNSNNNHGSNYNNFNNGNSYIKGWNKNFNKYRRPSSSSYTGKSPLSRYNMSYNHNNNSSINGYARRGSTTTVQHSPGAYIPPNARNHHVSPTNQFLRVPQSTAPDISTVLGGKPSYQEHYTQDSMDSEGDHDSDDVLFTLEEGDHDFVNGMDNLSINDHLPHTTVGSHNEVFVHASTNHNNNGNNNHIDTNSTTNQYHRQYIPPPLTTSLHINNNNNESNELPDLLKSPASSEAHLNLSSGPIDPILTGNIGNRYSHSSDSKELEQERRLSMEQKFKNGVYVPPHHRKSFNLGTQVPPMNMKTSNEATLSVSHNSVNFGGSYNSRRSSANESNPLHMNKALEKLSSSPGAKSSFVGFPKPLLPRNHSSTTIALQNEDVFADSNNDAIIFEDEEYEGESDKMAHGKMEGGDNESSSTSPDERQIFGPYEIYAQTFAGSTHDKKLGAGRKTSIQDEMVGSLEQYKNNWLILQQQD
Protein: Glycogen synthase kinase-3 beta (EC 2.7.11.26) (B2LUN4)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
Protein: Ran-binding protein 3-like (Q86VV4)
Organism: Homo sapiens (Human)
Function: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.
Subcellular location: Nucleus {ECO:0000305|PubMed:25755279}. Cytoplasm {ECO:0000305|PubMed:25755279}.
Interaction partners:
Sequence:
MTTIPRKGSSHLPGSLHTCKLKLQEDRRQQEKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHITDSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISEGNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIKNTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLNDTASTDCGTLQSRLIMRNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDVNQAESLSETAQQLNCESCDENEDDFIQVTKNGSDPSSWTHRQSVACS
Protein: Serine/arginine repetitive matrix protein 4 (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (ZnSR100) (nSR100) (P0CB65)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8BKA3}.
Interaction partners:
- Polypyrimidine tract-binding protein 2b
- Polypyrimidine tract-binding protein 1
- RNA binding protein fox-1 homolog 1
- NOVA alternative-splicing regulator 1
- Serine and arginine-rich-splicing factor 11.
- ADAM metallopeptidase domain 23a
Sequence:
MAGVQQGEKQLFEKFWRGTFKAVATPRPESIIVASITARRAVTKLETPVGPKDDEEKVKAKDLVTKTHEKNGHIKRRGRKRHSHRRARSVSFDADLSPRPVPKTKKKKKKSQRKRRRHRSPSCSPSPVRKKKKKKSSKKRKRHRSASRKGRHSGSSSRRKRKEDKKHKKRSRSHSHRRHRHRKAEIRSSSCMENRSEDCEKSGFRDGGRSSDVHGGDACRSAVKLTNKISSKCCCHFSESTVSPSRSGVEGLSKVVIVQNSESSDGKRRADYDSGNDTSSPPSSKTGITRSKVAGNGKFSCLTSPEKLRLADGDNASDSGNSLTSYDSLGKPLLRENTLHSSVFSKLKGEESGRFCVDVEKTQPLDLISDRNRSPSHDRYEDGTRSRSRSISSQSRYSGRHSRSRSLSSGRRSYSRSSSYSLASRRDSLSSVSSCRSLNHSRCTTHRFRERKRYCSSCKSRKHSRRRPSSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSVSSRSSSILSWRLFPLTRSRTRSRSCSRSRSRSHSHTYSSYRSYSRSSSWNSLYSRRSRSRSRSYSRARR
Protein: Butanoate--CoA ligase AAE1 (EC 6.2.1.-) (4-methylpentanoate--CoA ligase AAE2) (EC 6.2.1.-) (AMP-binding protein 1) (AtAMPBP1) (Acyl-activating enzyme 1, peroxisomal) (Hexanoate--CoA ligase CCL3) (EC 6.2.1.-) (Pentanoate--CoA ligase CCL3) (EC 6.2.1.-) (F4HUK6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the ligation of CoA on butanoate to produce butanoyl-CoA. Can also use hexanoate, pentanoate and 4-methylpentanoate as substrates with a lower efficiency.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19329564}.
Interaction partners:
- Stress-response A/B barrel domain-containing protein UP3
- Plant intracellular Ras-group-related LRR protein 3
- Rop guanine nucleotide exchange factor 11
- Peroxisomal membrane protein 11A
- Cytochrome P450 72A13
- Putative acyl-activating enzyme 19
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Sequence:
MKMEGTIKSPANYVPLTPISFLDRSAVVYADRVSIVYGSVKYTWRQTRDRCVRIASALSQLGISTGDVVSVLAPNVPAMVELHFGVPMAGALLCTLNIRHDSSLVAVLLRHSGTKVIFADHQFLQIAEGACEILSNKGDKVPILVLIPEPLTQSVSRKKRSEEMMEYEDVVAMGKSDFEVIRPTDECDAISVNYTSGTTSSPKGVVYSHRGAYLNSLAAVLLNEMHSSPTYLWTNPMFHCNGWCLLWGVTAIGGTNICLRNVTAKAIFDNISQHKVTHMGGAPTILNMIINAPESEQKPLPGKVSFITGAAPPPAHVIFKMEELGFSMFHSYGLTETYGPGTICTWKPEWDSLPREEQAKMKARQGVNHLGLEEIQVKDPVTMRTLPADGVTMGEVVFRGNTVMNGYLKNPEATKEAFKGGWFWSGDLGVKHPDGYIELKDRSKDIIISGGENISSIEVESTLFTHPCVLEAAVVARPDEYWGETACAFVKLKDGSKASAEELISYCRDRLPHYMAPRSIVFEDLPKTSTGKVQKFVLRTKAKALVSLSKKGRSKL
Protein: Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (Q27580)
Organism: Drosophila melanogaster (Fruit fly)
Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Interaction partners:
- Cystathionine beta-synthase
- Betaine-homocysteine S-methyltransferase
- cystathionine gamma-lyase
- Adenosylhomocysteinase-like 1
- FI01821p
- FI04487p
- Adenosylhomocysteinase-like 2
- Uncharacterized protein
- S-adenosylmethionine synthase
- L-serine deaminase
Sequence:
MSKPSYKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIETLVELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMILDDGGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEVTTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAKEKVNVKPQVDRYTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTKSDKYAVGVHVLPKILDEEVASLHLEKLGVKLTKLTEKQATYLGVSQTGPFKPDHYRY
Protein: Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT) (Q9H598)
Organism: Homo sapiens (Human)
Function: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O35458}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000250|UniProtKB:O35633}. Note=Presents in glycine-, GABA- or GABA- and glycine-containing boutons. {ECO:0000250|UniProtKB:O35458}.
Interaction partners:
- Vesicular glutamate transporter 1
- Vesicular glutamate transporter 2
- Glutamate decarboxylase 2
- Vesicular glutamate transporter 3
- Vesicular acetylcholine transporter
- Glutamate decarboxylase 1
- Synaptic vesicular amine transporter
- Chromaffin granule amine transporter
- Gephyrin
- Synaptotagmin-1
Sequence:
MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQMDILKAEGEPCGDEGAEAPVEGDIHYQRGSGAPLPPSGSKDQVGGGGEFGGHDKPKITAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVVRVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYSGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED
Protein: Topoisomerase I damage affected protein 11 (P38854)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNMRKFKTTTKFQKDNAGNNSLTDESGHRTREKKSKRSSNKLSFIGEPDNDNSSVKNSVEMTDF