wanglab/gogpt-training-data huggingface dataset:
Protein: Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) (Q8N5V2)
Organism: Homo sapiens (Human)
Function: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.
Interaction partners:
- Ephrin type-A receptor 1
- Transforming protein RhoA
- Ephrin type-A receptor 4
- Cell division control protein 42 homolog
- Ephrin type-B receptor 2
- Ephrin type-A receptor 2
- Ephrin type-B receptor 1
- Ephrin type-A receptor 3
- Ephrin type-A receptor 5
- Ephrin type-A receptor 8
Sequence:
METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIKRNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQTDPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (D1YSF9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTKSALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDL
Protein: Cytochrome P450 1A3 (CYP1A3) (EC 1.14.14.1) (CYP1A1) (Q92109)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MVLMILPIIGSVSASEGLVAMVTLCLVYMIMKYMHTEIPEGLKRLPGPKPLPIIGNMLEVHNNPHLSLTAMSERYGSVFQIQIGMRPVVVLSGNETVRQALIKQGEDFAGRSDLYSFKFINDGKSLAFSTDKAGVWRARRKLAMSALRSFATLEGTTPEYSCALEEHVLKEGEYLVKQLTSVMDVSGSFDPFRHIVVSVANVICGMCFGRRYSHDDQELLGLVNMSDEFGQVVGSGNPADFIPILRYLPNRTMKRFMDINDRFNNFVQKIVSEHYESYDKDNIRDITDSLIDHCEDRKLDENANIQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVAYPETQERLHQELKEKVGMIRTPRLSDKINLPLLEAFILEIFRHSSFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVNHDPELWKEPSSFNPDRFLSADGTELNKLEGEKVLVFGMGKRRCIGEAIGRNEVYLFLAILLQRLRFQEKPGHPLDMTPEYGLTMKHKRCQLKASMRPWGQEE
Protein: Coumarin 8-geranyltransferase 1, chloroplastic (EC 2.5.1.138) (Prenyltransferase 1) (ClPT1) (Umbelliferone 8-C-geranyltransferase) (U8GT) (A0A077K8G3)
Organism: Citrus limon (Lemon) (Citrus medica var. limon)
Function: Prenyltransferase specific for geranyl diphosphate as prenyl donor and coumarin as prenyl acceptor. Can use umbelliferone and esculetin as substrates, and with a lower activity, 5,7-dihydroxy-coumarin and 5-methoxy-7-hydroxycoumarin. No activity with 5-hydroxy-7-methoxycoumarin, bergaptol, xanthotoxol, p-coumaric acid, caffeic acid, 2,4-dihydroxycinnamic acid, kaempferol, genistein or homogentisate. No activity with dimethylallyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as prenyl donors.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:25077796}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLQMHSNSSFSPKCYYPLQHAGCVKTLQLPLTKVHGGLNRSESKNYAIKCTQSDSFYSTNKIRNNENSSSRNCKPFNKYRVAVTLQQQDCASNNEDDINSTSFRDVLLKKLHALYVFTRPFAMIGTIVGITSIAILPLQSFADLTPKYFMEFLKALLSAVLMNNYVGTVNQVADVEIDKVNKPGLPLASGDLSVGTGLAITLILSLTSLAIALSLQSPPLIFGLIVWFLLGTAYSVDLPFLRWKTNPFLAGMCMVIVFGLVYQFSFFIHFQKYVLGRPVVITRPLIFAAAIISTISAVMSLLKDIPDEDGDKQFGYQSISSKLGKENVLRLCVYALFFAYGVAVIVGASSSFQLGKLVSIIGHSTLAFLLWLRAQTVDLSNNASTFSFYLFVWKLFYGEYLLIHFLR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F5GWT4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVAQGQSQGQPSSSSLTGVSSSQPIQHPQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQSTQGVSQVAPAEPVAVAQTQATQPTTLASSVDSAHSDVASGMSDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHCPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSAVGPVSMAAPTAITEAGTQPQKVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLVKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPKKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHLKEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPVGTASLQNFNISNLQKSISNPPGSNLRTT
Protein: Protein fuzzy homolog (Q3UYI6)
Organism: Mus musculus (Mouse)
Function: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000305}.
Interaction partners:
- Ciliogenesis and planar polarity effector 2
- Protein inturned
- WD repeat-containing and planar cell polarity effector protein fritz homolog
Sequence:
MGDEGPGSPVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIVLSSEEGTSELRLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSAMQETLSGFAEATGTAFVSLLVSGRVVAATEGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGQLDPQLMERWWQPLLEPLRACLPLGPRALPEGFPLHSDILGLLLLHLELRRCLFTMEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVYPAQMPRACYLVLGPGMGWQLVAVQLGLRLLLLLLSPHTPTHGLRSLATRTLQALTPLL
Protein: EF-hand domain-containing protein D2 homolog (Swiprosin-1 homolog) (Q9VJ26)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSVSSNASSASNKDSVDSPSSTTNTDSSELTHILNRRQEIMESQEAGIEVRRTYKVVNVYTDFPEFSRNQIKDYQKTFNTYDTARDGFLDLQELKFMMEKLGAPQTHLGLKQMIAEVDEDNDGKISFREFLLIFRKAQAGELDSDSGLNQLARLTEVDVEQVGVSGAKNFFEAKIEQQLRTNKFHDEIRAEQEERRREEEERAQRRQQFQQRAAIFQ
Protein: Promyelocytic leukemia zinc finger protein (Zinc finger and BTB domain containing 16) (Q5S3S9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Retinoic acid receptor, alpha
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- Nanos C2HC-type zinc finger 2
- Deleted in azoospermia-like.
- Cullin-3
- BMI1 proto-oncogene, polycomb ring finger.
- Histone deacetylase 1
- Histone deacetylase 4
- Histone deacetylase 1
Sequence:
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKILETIQASDDNDTEATMADGGGEEEEDRKARYLKNIFISKHSGEESGYANVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGALQPPAGPEEPTLAGGGRHPGVAEVHMEMMQVDEAPGQDSPGAAESSVSGGMGDKLEERSKEGPGTPTRGSVITSARELHYGREESGEQLSPPVEAGQGPPGRQESLAPPVEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKAESRPLGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
Protein: BRCT domain-containing protein (Q38G07)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- T. brucei spp.-specific protein
- Uncharacterized protein
- Fibronectin type-III domain-containing protein
- Cilia-and flagella-associated protein 96
- Uncharacterized protein
- SH3 domain protein, conserved
- Replication Factor A 28 kDa subunit, putative
- Uncharacterized protein
Sequence:
MSISESDSLWLQKSIHLADPIPEATGGGVETDENSRPGELLMVGEGMAKEVEELGGSSGPSSARFIHSTSQRASCRQSVSNASFASLHEIDELRARIAQLKREQLRWSGNQRELEIVRFELVQTQQELQTTREYARTLKEQLDEAEAKAEKEAKARRNSEAQLEKSISQSSRDKEFLKQQLEAMKEEHCRQLAEVEGRSEVEGSGRTEFMREQITKLTEDIEALDESNVKSREEACRLGRENELLRANIKSTQAKCDELQRSLESCTTRYAELENMHKIFVEKTERSQSEALDSLMATNNDRMKKIISSKEEIIDELREELKVFKGKSGSFSEEITNLQHRVRMLEAEAKQMTQEHEKELRSIRDQHHLALCQQQQESEILIREAKNGRVSLEEETSFLKRQAVKAAEELSAAAALIVQREEQLSHLESENITMRNALQAAERDRASAVDKLETARSELLQAEERTQHLQQQYDLTETVYSQDMLELKEKLAAAQVKLMQTESELSAVRQEKMKYETEAITNMSDLRSKLEEAECDRKRLQHAVEQASQTDKQLEQLRVKYLTMCKRAENMEIELAAVTSRCSLLEKRLDEEFRRSVRNASHSPVSLHFGGGNVCLRGIQSANVPPSASKQAKRSRSVEQRVFTISGFDGTELLEKIHKLPYATVAECKSNSPVPTNLTHLVTNGQLTVKLLTALVRGCWILPEAYVHESTKQKMWLDELSYGFRHVKLPIARKRIGFSEGFVSSRHLNTANLIIVEGGATVESNLTEADMILCTRSEYGNMENTRAVTWDKLVELIYPVKIGVVAEEVKQPQ
Protein: Probable early E4 11 kDa protein (P04489)
Organism: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Interaction partners:
Sequence:
MIRCLRLKVEGALEQIFTMAGLNIRDLLRDILRRWRDENYLGMVEGAGMFIEEIHPEGFSLYVHLDVRAVCLLEAIVQHLTNAIICSLAVEFDHATGGERVHLIDLHFEVLDNLLE
Protein: Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (Fas antigen ligand) (Q0VHD7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. Cytoplasmic vesicle lumen {ECO:0000256|ARBA:ARBA00004321}. Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGEVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
Protein: Kinesin-like protein KIN-14F (AtKIN14h) (Kinesin KP1) (Kinesin-like protein 1) (AtKP1) (Q8W1Y3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for keeping the ATP levels stable and balancing the aerobic respiration pathways during seed germination at low temperature.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:21406623}. Note=Associated with VDAC3 in mitochondrion. {ECO:0000269|PubMed:21406623}.
Interaction partners:
- Mitochondrial outer membrane protein porin 3
- At5g20110
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Thioredoxin M2, chloroplastic
- Mitochondrial outer membrane protein porin 4
- Mitochondrial outer membrane protein porin 1
- Kinesin-like protein KIN-10A
- Kinesin-like protein KIN-5A
- CMP-sialic acid transporter 1
- Dynein light chain
Sequence:
MDQGAMETLPEKPSEDEFSLALRNGLILCNVLNKVNPGSVLKVVENPITPAIQYADGAAQSAIQYFENMRNFLKAVEDMQLLTFGASDLEKGGSSNKVVDCILCLKGFYEWKQAGGVGVWRYGGTVRIVSFNRKGSSPPQYGIGSESTTDESVSLDESESSQYDQLLDFLHLSNEISAEESETAISLAFLFDHFALQLLHGYLKESDGINDMPLNEMVIDTLLNRVVKDFSAILVSQGAQLGSFLRKILKCDNGDLSRSEFLAAVFRYLQHRKDLVSKEFSKFCKCGGKLEFSRLNAREFSPGHVEAIGLQQKELEEVKSNFVETRSQVKQMQSEWQKELQRIVHHVKAMEVTSSSYHKVLEENRLLYNEVQDLKGTIRVYCRVRPFFQEQKDMQSTVDYIGENGNIIINNPFKQEKDARKIFSFNKVFGQTVSQEQIYIDTQPVIRSVLDGFNVCIFAYGQTGSGKTYTMSGPDLMTETTWGVNYRALRDLFQLSNARTHVVTYEIGVQMIEIYNEQVRDLLVSDGSSRRLDIRNNSQLNGLNVPDANLIPVSNTRDVLDLMRIGQKNRAVGATALNERSSRSHSVLTVHVQGKELASGSILRGCLHLVDLAGSERVEKSEAVGERLKEAQHINKSLSALGDVIYALAQKSSHVPYRNSKLTQVLQDSLGGQAKTLMFVHINPEVNAVGETISTLKFAQRVASIELGAARSNKETGEIRDLKDEISSLKSAMEKKEAELEQLRSGSIRNTTECQRARAVSPFHLPRTGNGAGTKAEASPQPNDGTRSYETRSCSTGKQRKSGFPSALRNREASPRMPNLAEERLNPSPSRRSLSTDRASTIKSRNKPDVTQNLPVSRTPFPARVPVVKSFSTVPLNPSAENNHRLHTDNSSEAFQNHQKLSARKLFPEIEEEHIRHALHIRQGGVKKTRAESSKAKAKQPSPARFQKLDVGISLRSDADSEAKVGNYQTQKGNNNHNVIHSRFQNFDVGISLFSDLCAGDKSDSTLKSDSSETDNEPPSKSKNAQRNSSKNSLNHKLRTIYAHEDTSLVDDKPSNGTAHIKEGNNNISMPEFRRSRSTHHARFMVP
Protein: LexA repressor 2 (EC 3.4.21.88) (P61609)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- Protein RecA
- DNA polymerase IV
- DNA polymerase IV
- DNA repair protein RecN
Sequence:
METLTSRQRTVLEFITAHVDRHGYPPTMREIARHLNVNGTLGVAKHLEALARKGYLQREPGNSRGITLTGQTRHTPTVSLPVIGVVRAGVPQIATEEIEEHISIDQSLVKGGAFFLRVKGDSMINAAIIEGDLALVRPQQTAENRDIVVAMIDGEATLKRFYQGADHIRLQPENPNMAPIIVRSGVQEAWIIGKVVGIYRRMD
Protein: Squamosa promoter-binding-like protein 11 (Q9FZK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase PUB22
- U-box domain-containing protein 13
- U-box domain-containing protein 20
- E3 ubiquitin-protein ligase PUB24
- AP-1 complex subunit mu-1
- E3 ubiquitin-protein ligase PUB23
- U-box domain-containing protein 12
- Cleavage and polyadenylation specificity factor
- U-box domain-containing protein 17
- Protein kinase PINOID 2
Sequence:
MDCNMVSSSQWDWEHLIMSNPSRTEDDSKQLPTEWEIEKGEGIESIVPHFSGLERVSSGSATSFWHTAVSKSSQSTSINSSSPEAKRCKLASESSPGDSCSNIDFVQVKAPTALEVSVASAESDLCLKLGKRTYSEEYWGRNNNEISAVSMKLLTPSVVAGKSKLCGQSMPVPRCQIDGCELDLSSAKGYHRKHKVCEKHSKCPKVSVSGLERRFCQQCSRFHAVSEFDEKKRSCRKRLSHHNARRRKPQGVFSMNPERVYDRRQHTNMLWNGVSLNARSEEMYEWGNNTYDTKPRQTEKSFTLSFQRGNGSEDQLVASSSRMFSTSQTSGGFPAGKSKFQLHGEDVGEYSGVLHESQDIHRALSLLSTSSDPLAQPHVQPFSLLCSYDVVPK
Protein: Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1) (P05546)
Organism: Homo sapiens (Human)
Function: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Interaction partners:
- Prothrombin
- Fibrinogen alpha chain
- Fibrinogen gamma chain
- Plasminogen
- Fibrinogen beta chain
- Tissue factor pathway inhibitor
- Histidine-rich glycoprotein
- Thrombomodulin
- Apolipoprotein
- Antithrombin-III
Sequence:
MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS
Protein: Lysyl oxidase homolog (EC 1.4.3.13) (F1QGY9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239, ECO:0000256|RuleBase:RU367046}.
Interaction partners:
Sequence:
MFFTISNFIFFLYLLQGLNNLTSAQSSAQWRNRVRWVNNGQVFSLMSTGSEFHAPVPSRRQSRVYQSSRTDAVPGRSMQIRLEAMDRPANSAPDSALLGPDRAQYIMANSRAPGARQMQVMQRHRAPPASRNNSTVPSEYSGGGGRTGENTRRGQAVANFQQIAAPTDNSNTVNSDNGNEARTPNVPAEQGATSETMPGDDPRNRNTVFYNIYPPGGRTIIPRRPPPGTGYGTRFFQNGLPDLVPDPYSIQAGSYIQRVQMYALRCAAEENCLARTAYRPTVRDLDYRVLLRFPQKVRNMGTADFLPVKPRHQWEWHSCHQHYHSMDAFSHYDLLDISTGRKVAEGHKASFCLEDTGCDPGFHRRYACTAHTQGLSPGCHDTYAANIDCQWIDITDVPPGNYFLKVTVNPDFLVAESDFSNNVVRCEVIYTGIYIQTRNCIITGS
Protein: Bactericidal permeability-increasing protein (BPI) (CAP 57) (P17213)
Organism: Homo sapiens (Human)
Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subcellular location: Secreted {ECO:0000269|PubMed:8812832}. Cytoplasmic granule membrane {ECO:0000269|PubMed:2722846}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269|PubMed:2722846}.
Interaction partners:
- Myeloperoxidase
- Neutrophil elastase
- Lactotransferrin
- Cathepsin G
- Azurocidin
- Cathelicidin antimicrobial peptide
- Myeloblastin
- Defensin alpha 4
- Lipopolysaccharide-binding protein
- Cell adhesion molecule CEACAM8
Sequence:
MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8IK76)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MCIRYINIIKIMKNININENSVFCYRKYYRKCNEIMNNSFNVKCDLRENEKLNKNKFPRLLVSYFYVLSIVGIIYCLLFNIHTHGNKDEGLVSTLCIDSRCLSEGYLNLYSPLCSNNPYFSFREILHGSNYYIPKEFMEWDDEEEKNGFQFDEDDEEDEEDDGDDDDDDDDDYDDEDEEEEDMKKKNYKNVPTKIDVKKPNNTNKVCDNKNSHIKNNTQQEEKNKNTTNQKSDANNKIHENKKKVEEEEKHKKEKNPNEKENNDNNKNKNEKKNGKGNQGNNKDLPAYKTIDYNNLSVQISLEDFQAILNSLDSVLSAKEMHNLWNQLRGIERFLFEDTVSDLFTVYHDLLETYNLTAKETEHIWKNCLSDARHSQSYAETQCNVDHNNFIRKKNLTQEAYKNYLTQSREKFSKLRDEIHDKGETYLNEQITKYRKAKYNNLDQASKKKKKENEKEKERKRKEKEQEKEKEKQRKQKEQEKERKRKEKEQEKERKNKENKKKETKNKIKTWK
Protein: Defective in cullin neddylation protein 1 (Q8WZK4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
Interaction partners:
- NEDD8-conjugating enzyme ubc12
- Cullin-1
- RING-box protein pip1
- Cullin-3
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin-like protein 1
- COP9 signalosome complex subunit 5
- Cullin-4
Sequence:
MKPDTVSLTRAFSKATSTSSKAALSWLKKYNFDYDVAYTKWIQQKSREEAEKQLNNVFSQFSSKEDKDLIELDGSVQLFTALDISLEDPETLLVSYFLKSPRMGEFHRESFVEGALNLSTTSLDQLKLAIKEKVQVWRSDASLQKAIYIYTYPLACDKGKKTLSTSIAIEFFQILLKDTFPLLDDWIAFLKVSPIIEKSLPKDTWNELWDFSVFVKSDPNCSNYDFEGAWPTLIDEFVSYYREHGYKNSSS
Protein: Cation channel sperm-associated protein 4 (CatSper4) (Q7RTX7)
Organism: Homo sapiens (Human)
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q8BVN3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BVN3}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000250|UniProtKB:Q8BVN3}.
Interaction partners:
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated protein 3
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated protein 2
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated auxiliary subunit epsilon
- Cation channel sperm-associated auxiliary subunit zeta
- Cation channel sperm-associated auxiliary subunit TMEM262
- Cation channel sperm-associated auxiliary subunit gamma
Sequence:
MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH