wanglab/gogpt-training-data huggingface dataset:
Protein: GRAS family protein RAD1 (Protein REQUIRED FOR ARBUSCULE DEVELOPMENT 1) (LjRAD1) (A0A1B1WAJ0)
Organism: Lotus japonicus (Lotus corniculatus var. japonicus)
Function: Transcription factor acting as a regulator of arbuscular mycorrhiza (AM)-related genes (e.g. PT4, STR and RAM2). Required for the morphogenesis of arbuscules upon symbiosis with AM fungi (e.g. Rhizophagus irregularis). Also involved in restricting mycorrhizal colonization of the root meristem.
Subcellular location: Nucleus {ECO:0000269|PubMed:25560877}.
Interaction partners:
Sequence:
MSPPLYSVLLEDENSVFLLDLDLSSPMGFHAYPHLPILDSSIANWSLPFSISDETFRESKKLKRTMIPISSADFSISSSSSLSVSVNSIPRLNFRDHIRTYKRYLAAEELPEDTNSSESVVGAEEDGCADGMRLVQLLIACAEAVACRDKAHASMLLSELKSNALVFGSSFQRVASCFVQGLAERLTLIQPIGSGAGVSQSMMNIMDAASEEMEEAYRLVYETCPHIQFGHFVANSTILEAFEGESFVHVVDLGMSLGLPHGHQWRGLIHSLANRASGHGRVRRLRITAIGLCIARLQAIGDELSDYANNLGINLEFSVVQKNLENLQPEDIKVNDDEALVVNSILQLHCVVKESRGALNSVLQMIHGLSPKVLVMVEQDSSHNGPFFLGRFMESLHYYSAIFDSLDAMLPKYDTKRAKMEQFYFAEEIKNIVSCEGPLRMERHERVDQWRRRMSRAGFQAAPIKMVAQAKQWLLKNKICDGYTVVEEKGCLVLGWKSKPIVAASCWKC
Protein: Stevor (Q8IEU4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKMHYLKMLLFTFLINILGSPHNENYLNNHYNISIVQNNTKRTTINSRLLAQTKNHNPHYHNDPELKEIIDKMNEEAIKKYQKMHDPYKQLKEVVEKNGTKYTGGNDAEPMSTLEKELLETYEETFGDKKHIMLKSGINTNQYDKSIDESSTCGCTDNNKAKLETTKGKDKYLKHLKEGCTRSICFCSVSTVFLTLIALAFAKKAAVASLVYYGEAFQNCVSSSSLFYIFDSVSLTTAIQTASKCASLAGATDAGGTAAGAAMGIFYPCGIAALVLLILAVVLIILYIWLYRRRKNSWKHECKKHLCK
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (M9PDK3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSWTNSAQHKKSTQSVSVTASPNSVNNGPGVGAAGKANYSHTTKTFTNQQHYQQQHYHTQNSYNNNSSGGGSSSNSSSSSSNNQPQVRNYGTMKMPSSPVAWTAPTPERKNSQQAAAAPAAATASAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAAQQHAQAAQTGAAAAPSKSHSNYASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTLPPQQQQTQQQNGGGSGGVVGSSSSSSNAGDNK
Protein: Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) (Telomeric repeat-binding subunit 3) (A0A0U8UFF4)
Organism: Tetrahymena thermophila (strain SB210)
Function: Component of the heterotrimeric replication protein A (RPA) and holoenzyme telomerase ribonucleoprotein complexes. As part of the heterotrimeric RPA complex, binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress (By similarity). It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (By similarity). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (By similarity). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation (By similarity). Also part of a subcomplex of the holoenzyme telomerase ribonucleoprotein complex: this subcomplex that contains TEB1, RPA2/TEB2, RPA3/TEB3, but not RPA1, mediates the recruitment of telomerase to telomeric DNA via specific interaction between TEB1 and telomeric ssDNA. In the holoenzyme telomerase ribonucleoprotein complex, RPA2/TEB2 and RPA3/TEB3 act as assembly factors for TEB1 incorporation into telomerase holoenzyme. In the holoenzyme telomerase ribonucleoprotein complex, RPA3/TEB3 does not contribute to ssDNA affinity, while it contributes to ssDNA affinity in the RPA complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P35244}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
Sequence:
MDAEQEQVMYPRILFEQMAQFRGKKVTVVGNVCNEDQNDSLVIEFGPTGLNQHVVIDNYRRVDLNNTTKFVEIRGVVLNQNIVSCEELTEFEQKDPFDFDTYSKLIHLSQSDKLSSLFTDQ
Protein: Proteasome subunit beta type-1 (Proteasome 26 kDa subunit) (P40304)
Organism: Drosophila melanogaster (Fruit fly)
Function: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-3
- Proteasome subunit beta
- Proteasome subunit alpha type-7-1
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit beta
- Proteasome subunit beta
Sequence:
MSRLGFEQFPDYQVPGMKHPDFSPYESNGGSIVAIAGDDFAVIAADTRLSSGYNIHSRTQSKLFKLSPQTVLGSAGCWADTLSLTGSIKVRMQSYEHTHLRTMTTEAVAQMLSIAMYNRRFFPYYVSNILAGIDNEGKGVVYSYDPIGHCEKATYRAGGTAGTLLQPVLDNQIGHKNMNLEDADKIKLTKERAVSVASDTFISAAERDIYTGDSVLINIITKDGIEVRTLTLRQD
Protein: Glycerol:H+ symporter (Gup1), putative (Q4WHK8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Acyl carrier protein
Sequence:
MTSILSWFRRLYSLDTLDTRFTSSATTSLKAAADTRPPSAKDARANAIANGASPPNWRTPEFFVYYLVFLTVVPMMFKTVIDASKESHPGYSAYEHLLSPGWIPGRKVDNSDAQFSNFRDNIPYLLILLVAHPLLRRVYERYLLRSDASSVSRSADAATTGDARLDRRVRFDYYFALVFITALHGVSAIKVLVILYLNYKIAKSLPRKYIPAATWIFNISALFSNELCAGYPLERVATFFAAGGGGGEPSLVQWAKYIDGFGGLIPRWEILFNLTVLRLISFNMDYYWSLDYPAGSAIEKKQLDPAALSERDRVSIPPEQSAFSARNYVAYALYSPLYLTGPILTFNDYIAQQRYPPPSLTKTRTLLYGIRFFLTLLSMELMLHYIYALAISQASPDWSLYSTGQLSMLAFFNLHMIWLKLLIPWRFFRLWALVDGIDPPENMVRCVSNNYSVFAFWRGWHRSFNRWIVRYLYIPLGGGARSGGANKSSPALLSKARQIFNFLVVFTFVALWHDINLRLLMWGWLITLFFLPETIATLLFPARTWRSRPTAYRVLCGVGAVGNILMMMIANLVGFALGLDGLKGLLTEILGSYSGIGFLIAACGALFVGAQVMFEIREEELRAGIKMKC
Protein: Calnexin (Q920L9)
Organism: Mesocricetus auratus (Golden hamster)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Melanosome membrane {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004573}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004583}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004583}.
Interaction partners:
Sequence:
MEGKWLLCMLLVLGTAIVEAHDGHDDDMIDIEDDLDDVIEEVEDSKSKSDSSTPPSPKVTYKAPVPTGEVYFADSFDRGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKDTKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTSELNLDQFHDKTPYTKMFGPDKCGEXYKLHFIFRHKNPKTGVYEEKHAKRPDAHLKMYFTDRKTHLYTLVLNPDNSFEILVDQFIVNSGNLLNDMTPAVNPSREIEDPEDQKPEDWDERPKIPDPDAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYIPDPDADKPEDWDEDMDGEWEAPQIANPKCESAPGCGVRQRPEIDNPNYKGKWKPPMIDIPNYQGVWKPRKIPNPDFFEDDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDDWANDGWGLKKAADGAAEPGVVGQMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQSSAMQYKKTDAPQPDVKEEDGKEEEKNKGDEEEEGEEKLEEKQKSDAEDDGGTGSQDEEDRKPTAEEDEILNRSPRNRKPRRE
Protein: Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) (P97371)
Organism: Mus musculus (Mouse)
Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Interaction partners:
- Proteasome activator complex subunit 2
- Proteasome subunit beta type-10
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-8
- Proteasome activator complex subunit 3
- Proteasome subunit beta type-9
- Interferon gamma
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-4
Sequence:
MATLRVHPEAQAKVDVFREDLCSKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEEKEEKKKGDEDDKGPPCGPVNCNEKIVVLLQRLKPEIKDVTEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTNLHTKLEGFHTQISKYFSERGDAVAKAAKQPHVGDYRQLVHELDEAEYQEIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY
Protein: Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) (Q16763)
Organism: Homo sapiens (Human)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
Interaction partners:
- Cell division cycle protein 20 homolog
- Anaphase-promoting complex subunit 11
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 10
- Polyubiquitin-C
- Cell division cycle protein 23 homolog
- Ubiquitin-like modifier-activating enzyme 1
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 5
Sequence:
MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGRAEAGRALASGTEASSTDPGAPGGPGGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL
Protein: Rho-type guanine nucleotide exchange factor, isoform D (A8DZ20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}.
Interaction partners:
Sequence:
MDQPLVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMGIKRQLSNLSNSSLGHLNAAHMSPPSSHILLPPGGRPPATPSSIPAGSSSGGSHSHQGSPATNSMSHHKRSQSFNHHLSYNQYTPTQPPPHHLHPPQPPSLPSHLGASGPRSSSAQTPNSKTAAPLQASSMDASPAIQAAAAAAAAAVGMGVPSARKGSTKANWTISCLRPTPPLRPSLLNATSGSGSGSGGSGGGGSSSSNALASYCSGRKNQPTYEEDALVLRVFEAYCAAYQNNARNTIHSALQPWTPCLPIRGGKLKTSKTFSTSNPQLPFIANVGNSAYLNQHQQQHLQQQHLQQQHLQQQHLAQQQPGRQHSAGSLNSSFIWREASPNNFNLYSSSVSSSLNATPAQRYSLSGTAGGSTSIKDYQRALSEERATRKSLNRLKSGFGSGYDNVCTSPLLPRKNKPAPKLVAQQSYQRSPGNATATTIVKPNPPGHPGLYDRRLNRSFETSTSHRYAGYGAGYLMNCGGALRTSTLQRSTPQLAGGERSDDSDVERELLRGNGAGPTASLELNPDGSKRQSGSWCCGLENEDMTPTLRQLWTAIRQMQQDMSQIKLQINEERALRADLQQLLMQHLETSSVSSGANTPKC
Protein: NAD-dependent protein deacylase Sir2A (EC 2.3.1.-) (PfSir2) (PfSir2A) (Regulatory protein SIR2 homolog A) (Q8IE47)
Organism: Plasmodium falciparum (isolate 3D7)
Function: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Involved in recruiting ORC1 to the telomers and subtelomeric repeat regions (TAREs) and promoters of var genes. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.
Subcellular location: Nucleus {ECO:0000269|PubMed:17827348, ECO:0000269|PubMed:22006844, ECO:0000269|PubMed:36947546}. Nucleus, nucleolus {ECO:0000269|PubMed:15820676, ECO:0000269|PubMed:18525026}. Chromosome, telomere {ECO:0000269|PubMed:15820676, ECO:0000269|PubMed:22379140}. Note=At the late ring stage/early trophozoites, co-localizes with ORC1 to telomeres and subtelomeric regions (TAREs) in the nuclear periphery (PubMed:18525026, PubMed:22379140). Spreads out from the telomere over a distance of at least 20-40 kb and is an important component of the heterochromatin complex around Rep20, a region that lies adjacent to the regulatory 5'-UTR element of telomeric var genes (PubMed:15820676). May relocate to the cytoplasm during the multiple rounds of DNA synthesis and nuclear mitosis in trophozoite stage (PubMed:18525026). {ECO:0000269|PubMed:15820676, ECO:0000269|PubMed:18525026, ECO:0000269|PubMed:22379140}.
Interaction partners:
- 3'-5' exonuclease
- Histone H4
- NAD-dependent protein deacetylase Sir2B
- Histone H3
- Histone H3-like centromeric protein CSE4
- Histone H3
- Histone deacetylase
- Origin recognition complex subunit 1
- AP2 domain transcription factor AP2-FG, putative
- SANT domain-containing protein
Sequence:
MGNLMISFLKKDTQSITLEELAKIIKKCKHVVALTGSGTSAESNIPSFRGSSNSIWSKYDPRIYGTIWGFWKYPEKIWEVIRDISSDYEIEINNGHVALSTLESLGYLKSVVTQNVDGLHEASGNTKVISLHGNVFEAVCCTCNKIVKLNKIMLQKTSHFMHQLPPECPCGGIFKPNIILFGEVVSSDLLKEAEEEIAKCDLLLVIGTSSTVSTATNLCHFACKKKKKIVEINISKTYITNKMSDYHVCAKFSELTKVANILKGSSEKNKKIM
Protein: RE51969p (Q8SX30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPLLQQAPVSTQLRRYPYDVIVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQASPSLLKAQLSHQQQLPQQHLQQAQLNHHHQHLEMPMSMPVPGHGSYLERPSNNISATLALHQQPQL
Protein: Mitochondrial inner membrane m-AAA protease component YTA10 (EC 3.4.24.-) (EC 3.6.-.-) (ATPase family gene 3 protein) (Tat-binding homolog 10) (P39925)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:8681382}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial inner membrane m-AAA protease component YTA12
- Prohibitin-1
- Inner membrane mitoribosome receptor MBA1, mitochondrial
- Prohibitin-2
- Mitochondrial metalloendopeptidase OMA1
- Lon protease homolog, mitochondrial
- Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
- Large ribosomal subunit protein bL32m
- Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
- Mitochondrial inner membrane protein OXA1
Sequence:
MMMWQRYARGAPRSLTSLSFGKASRISTVKPVLRSRMPVHQRLQTLSGLATRNTIHRSTQIRSFHISWTRLNENRPNKEGEGKNNGNKDNNSNKEDGKDKRNEFGSLSEYFRSKEFANTMFLTIGFTIIFTLLTPSSNNSGDDSNRVLTFQDFKTKYLEKGLVSKIYVVNKFLVEAELVNTKQVVSFTIGSVDIFEEQMDQIQDLLNIPPRDRIPIKYIERSSPFTFLFPFLPTIILLGGLYFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNKETDIKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKGGALGGANDEREATLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVNGRQQIYLVHLKRLNLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHHFEQAIERVIAGLEKKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLLKVSIIPRGQGALGYAQYLPPDQYLISEEQFRHRMIMALGGRVSEELHFPSVTSGAHDDFKKVTQMANAMVTSLGMSPKIGYLSFDQNDGNFKVNKPFSNKTARTIDLEVKSIVDDAHRACTELLTKNLDKVDLVAKELLRKEAITREDMIRLLGPRPFKERNEAFEKYLDPKSNTEPPEAPAATN
Protein: Transmembrane protein 98 (Protein TADA1) (Q9Y2Y6)
Organism: Homo sapiens (Human)
Function: Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
Subcellular location: Cell membrane {ECO:0000269|PubMed:25946230}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Secreted {ECO:0000269|PubMed:25946230}. Secreted, extracellular exosome {ECO:0000269|PubMed:25946230}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Note=Secreted by exosomes through a non-classical pathway. {ECO:0000269|PubMed:25946230}.
Interaction partners:
- Serine protease 56
- Myelin regulatory factor
- Vesicle-associated membrane protein 8
- Membrane frizzled-related protein
Sequence:
METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI
Protein: F-box-like/WD repeat-containing protein ebi (Q95RJ9)
Organism: Drosophila melanogaster (Fruit fly)
Function: F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral nervous system and central nervous system in a process that does not involve the degradation of ttk. Involved in cone cell development by preventing the transcriptional repression mediated by Su(H) on Dl, probably by participating in a E3 complex that contains sno and mediates the ubiquitination and subsequent proteasomal degradation of some component of the Su(H) repressor complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:10215623}.
Interaction partners:
- Protein MBD-R2
- Smrter, isoform G
- Histone deacetylase
- E3 ubiquitin-protein ligase sina
- Histone deacetylase HDAC1
- Armadillo segment polarity protein
- Probable E3 ubiquitin-protein ligase sinah
- GEO01111p1
- LD41464p
- CG11942
Sequence:
MSFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWSVGEDGEVARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEIKIEPGTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGSNSTSTPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQPTSGLTPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTISSSTSGGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARIWDMSDANTNSNQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKGPIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIHVCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTIKWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSFDKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASASDGSVFVLDLRKF
Protein: Large ribosomal subunit protein bL28m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (Q2HJJ1)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941}.
Interaction partners:
- Small ribosomal subunit protein mS26
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL15m
- Ribosomal_L18e/L15P domain-containing protein.
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein bL12m
- MRPL41 protein
- Small ribosomal subunit protein mS34
- Large ribosomal subunit protein uL4m
Sequence:
MPLHKVPVGLWKRLRLREGIYSRLPAHYLRSLEEARTPTPVHFRPHGAKFKINPKNGQRERVEDVPIPVHYPPESQLGLWGGEGWLKGHRYVNNDKFSKRVKKVWKPQLFQRELYSEILDTRFTVTVTMRTLDLIDEAYGFDFYILKTPKEDLCSKFGMDLKRGMLLRLARQDPQLHPDDPERRAAIYDKYKAFVIPEAEAEWVGLTLDEAVEKQRLLEEKDPVPLFKVYVEELVEQLQQQALSEPAVVQKRANRT
Protein: Actin (G3CKA6)
Organism: Spodoptera frugiperda (Fall armyworm)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMHVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVIAIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVMSGGTTMYPGIADRMQKEITALAPSTIKTKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKCF
Protein: Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) (Q8WU20)
Organism: Homo sapiens (Human)
Function: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Subcellular location: Endomembrane system. Note=Cytoplasmic, membrane-bound.
Interaction partners:
- Fibroblast growth factor receptor 1
- Tyrosine-protein phosphatase non-receptor type 11
- Growth factor receptor-bound protein 2
- Adapter molecule crk
- Son of sevenless homolog 1
- BDNF/NT-3 growth factors receptor
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- High affinity nerve growth factor receptor
- Crk-like protein
Sequence:
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
Protein: Putative translation factor sui1 (Q4QAL1)
Organism: Leishmania major
Interaction partners:
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS8
- 40S ribosomal protein S30
- 40S ribosomal protein S4
- Putative 40S ribosomal protein S27-1
- 40S ribosomal protein S24
- 40S ribosomal protein S7
- Putative 40S ribosomal protein S13
- Putative 40S ribosomal protein S15A
- Ribosomal protein S16
Sequence:
MEDTVEAIVNQQRETERAVLGGQKVHIRVQQRKGKKFVTTVQGLNQKLNFRRINREFQRRWGCNGTVISTPDAGTVIQLQGNWSENIKQFLLDEHMATENNLEIHSL