wanglab/gogpt-training-data huggingface dataset:
Protein: Replication factor C (activator 1) 5 (Replication factor C subunit 5) (Replication factor C subunit RFC5) (Q6DRK4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cell cycle checkpoint protein RAD17
- Replication factor C
- Replication factor C
- Replication factor C subunit 1
- Replication factor C
- Proliferating cell nuclear antigen
- Sister chromatid cohesion protein DCC1
- Chromosome transmission fidelity protein 18 homolog
- ATPase family AAA domain-containing 5b.
- Cell cycle checkpoint control protein
Sequence:
MASTSKTQPQARNLPWVEKYRPQTLDDLISHQDILSTIQKFISEDRLPHLLFYGPPGTGKTSTILACARQLYKDKEFNSMVLELNASDDRGIDVVRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLSQNQMIPRLEHVIQQESIDITPDGMKAIVTLSTGDMRRSLNILQSTHMAYGKVTEETVYTCTGHPLRSDIANILDWALNKDFTTAYNQILELKTLKGLALHDILTEVHLLIHRVDFPPSIRMGLLIKLADIEYRLASGTSEKIQLSSMVAAFQAVRDIVVSDG
Protein: Protein Wnt (B0LK22)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Protein wntless homolog
- Low density lipoprotein receptor-related protein 5
- Secreted frizzled-related protein 5.
- Porcupine O-acyltransferase
- Frizzled-5
- Secreted frizzled-related protein 1
- Frizzled 8a protein
- Catenin beta-1
- Frizzled class receptor 1
- Frizzled class receptor 10
Sequence:
MDLYLVGFLMCMWFSSSRVLGGYPIWWSLALGQQYSSIGSQPILCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIKDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTMCGCDSHHKGPPGEGWKWGGCSEDAEFGVLVSREFADARENRPDARSAMNRHNNEAGRMTILENMHLRCKCHGLSGSCEVKTCWWAQPDFRLLGDYLKDKYDSASEMVVEKHRESRGWVETLRAKYAFFKHPTERDLVYYEGSPNFCEPNPETGSFGTRDRACNVSSHGIEGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECVRVYDVHTCK
Protein: Transgelin (M9PE30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYQSKINSKYSEELAQESLEWIKAVTEEPINTSGDTDNFFEVLKDGVILCKLANALQPGSIKKINESKMAFKCMENISAFLACAKNFGVPTQETFQSVDLWERQNLNSVVICLQSLGRKASNFNKPSIGPKEADKNVRNFSDEQLRAGANVISLQYGSNKGATQSGINFGNTRHM
Protein: Inner kinetochore subunit CTF19 (CENP-P homolog) (Constitutive centromere-associated network protein CTF19) (Q6CRN7)
Organism: Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q02732}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q02732}.
Interaction partners:
- Inner kinetochore subunit MCM21
- Inner kinetochore subunit OKP1
Sequence:
MDFTSSSGVLDSERNTGSNDSDEPSSHSDVIETEELKLIKLQEHKNNLLRQRSELLDQLSQTRVVEPRSVQLDDKLLLKLLRRNDNAVSDSSQSSNNPLPRVLPSLNIEQRKKYLDITLNDVTVTCEKDMILLRKGSFTASFRIAVENESIRSMAIDLNAFEVELQPIIQYAEDTQNVNVAMMAVVQFLRIKELHEQMISKIVEASKFIRASNNTITLNDLEVSFHCYWNLPSPYPETLILTNKVQKILDFLIYQYGIQLGVIKYGSTII
Protein: Porflan (P86295)
Organism: Potamotrygon orbignyi (Smooth back river stingray)
Function: Inflammatory peptide. Induces leukocyte recruitment and adherence to the vascular endothelium when applied to mouse cremaster muscle.
Subcellular location: Secreted {ECO:0000269|PubMed:19682520}.
Interaction partners:
Sequence:
ESIVRPPPVEAKVEETPE
Protein: FI04439p (TBC1 domain family member 16) (Q9VKV6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- small monomeric GTPase
- Diacylglycerol kinase
Sequence:
MPIGSIIKKASSFILGDERLDRKIDIAYEDNEILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIREEDENAADMQELKNELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQLPKIPCTLSGLCKRCGPGMWDSEHRPALECVGHSDDEKCSLSID
Protein: Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) (Q9UBT7)
Organism: Homo sapiens (Human)
Function: May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12270917}. Cell membrane {ECO:0000269|PubMed:12270917}; Peripheral membrane protein {ECO:0000269|PubMed:12270917}.
Interaction partners:
- Actin-like protein 7A
- Actin-like protein 7B
- Dystrophin
- A-kinase anchor protein 13
- Dystrobrevin alpha
- Utrophin
- Gamma-2-syntrophin
- Beta-2-syntrophin
Sequence:
MAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIACIEAKQAGETIAALTDITNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLADRVVIKQIITSRNKVLATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMAAARAVLEKCTMMLLTASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTDCKPNGETDISSISIFTGIKEFKMNIEALRENLYFQSKENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELHSTATQLAADLLKYHADHVVLKALKLTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYGYLSLPKPMKNNANLKSLKPDKPDSEEQAKIAKLGLKLGLLTSDADCEIEKWEDQENEIVQYGRNMSSMAYSLYLFTRGEGPLKTSQDLIHQLEVFAAEGLKLTSSVQAFSKQLKDDDKLMLLLEINKLIPLCHQLQTVTKTSLQNKVFLKVDKCITKTRSMMALLVQLLSLCYKLLKKLQMENNGWVSVTNKDTMDSKT
Protein: FI02817p (GEO13220p1) (Q9VKA1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
Interaction partners:
- UPAR/Ly6 domain-containing protein crok
- Uncharacterized protein, isoform B
- RE19849p
- UPAR/Ly6 domain-containing protein CG9338
- UPAR/Ly6 domain-containing protein cold
Sequence:
MNVLLRCTFLLLTLAICGSWAIRCYQCSSDQDRKGHDSCGAYKRFNRTEHISIECNSDESHMPGSFCMKVVQQGPRGFIWDGRWRQVIRRCASVSDTGVVGVCNWGVYENGVYWEECYCSSDSCNGSSLVQMHGSLQLLLGLLLIGVASRIFRS
Protein: Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) (P45379)
Organism: Homo sapiens (Human)
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Interaction partners:
- Troponin C, slow skeletal and cardiac muscles
- Actin, alpha cardiac muscle 1
- Tropomyosin alpha-1 chain
- Troponin I, cardiac muscle
- Tropomyosin alpha-3 chain
- Troponin I, fast skeletal muscle
- Troponin I, slow skeletal muscle
- Troponin C, skeletal muscle
- Myosin-binding protein C, cardiac-type
- Myosin-7
Sequence:
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Protein: Large ribosomal subunit protein eL43z (Putative 60S ribosomal protein L37a-1) (Q9SRK6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g43860
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL38z/eL38y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein eL21z/eL21y
- Large ribosomal subunit protein eL21x/eL21w
- Large ribosomal subunit protein eL24y
- Large ribosomal subunit protein eL32z
Sequence:
MTKRTKKARIVGKYGTRYGASLRKQIKKMEVSQHNKYFCEFCGKYSVKRKVVGIWGCKDCGKVKAGGAYTMNTASAVTVRSTIRRLREQTES
Protein: Encapsulin nanocompartment protein Rv1762c (O06797)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Cargo protein of a type 1 encapsulin nanocompartment possibly involved in protection against oxidative stress.
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:34751132}. Note=Consistently identified in encapsulin nanocompartments isolated in situ. {ECO:0000269|PubMed:34751132}.
Interaction partners:
- Possible exported protein
- Possible oxidoreductase
- Probable PhiRv1 phage protein
Sequence:
MQSSSLDPVASERLSHAEKSFTSDLSINEFALLHGAGFEPIELVMGVSVYHVGFQFSGMRQQQELGVLTEATYRARWNAMARMQAEADALKADGIVGVRLNWRHHGEGGEHLEFMAVGTAVRYTAKPGAFRRPNGQAFSSHLSGQDMVTLLRSGFAPVAFVMGNCVFHIAVQGFMQTLRQIGRNMEMPQWTQGNYQARELAMSRMQSEAERDGATGVVGVHFAISNYAWGVHTVEFYTAGTAVRRTGSGETITPSFVLPMDS
Protein: Protein RecA (Recombinase A) (P0A7G6)
Organism: Escherichia coli (strain K12)
Function: Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA.
Subcellular location: Cytoplasm.
Interaction partners:
- Protein UmuD
- LexA repressor
- Regulatory protein RecX
- Protein UmuC
- DNA polymerase I
- Beta sliding clamp
- DNA damage-inducible protein I
- DNA repair protein RecN
- ATP-dependent DNA helicase RecQ
- DNA repair protein RadA
Sequence:
MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
Protein: Auxin-responsive protein IAA32 (Indoleacetic acid-induced protein 32) (Q8RYC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Auxin-responsive protein IAA33
- Auxin response factor 5
- Auxin response factor 7
- Putative auxin response factor 15
- Auxin response factor 22
- Auxin response factor 9
- Auxin response factor 20
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 18
- Putative auxin response factor 14
Sequence:
MDPNTPADFFKGSSKFHTYYSQTKKGGGVIDLGLSLRTIQHETYLPPARMIGLDGYGELIDWSQPSYNSITQLKSEDTGHQRLAQGYYNNEGESRGKYAYVKVNLDGLVVGRKVCLVDQGAYATLALQLNDMFGMQTVSGLRLFQTESEFSLVYRDREGIWRNVGDVPWKEFVESVDRMRIARRNDALLPF
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) (O95453)
Organism: Homo sapiens (Human)
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability.
Subcellular location: Nucleus {ECO:0000269|PubMed:9736620}. Cytoplasm {ECO:0000269|PubMed:9736620}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22442037}. Note=Some nuclear fraction is nucleolar.
Interaction partners:
- Far upstream element-binding protein 2
- Symplekin
- Cytoplasmic polyadenylation element-binding protein 1
- m7GpppN-mRNA hydrolase
- Poly
- Poly
- Polyadenylate-binding protein 1
- Poly
- Poly
- Poly
Sequence:
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW
Protein: Dedicator of cytokinesis protein 5 (Q9H7D0)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19004829}. Cell membrane {ECO:0000269|PubMed:19004829}. Cell projection, podosome {ECO:0000250|UniProtKB:B2RY04}. Note=Associated with the edge of the plasma membrane in Caco-2 intestinal epithelial cells spreading on type IV collagen. {ECO:0000269|PubMed:19004829}.
Interaction partners:
- Engulfment and cell motility protein 1
- Ras-related C3 botulinum toxin substrate 3
- Adapter molecule crk
- Engulfment and cell motility protein 2
- Crk-like protein
- Engulfment and cell motility protein 3
- Rho-related GTP-binding protein RhoG
- Cell division control protein 42 homolog
- Ras-related C3 botulinum toxin substrate 1
- Tumor necrosis factor receptor superfamily member 10D
Sequence:
MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFPETYIHLKEATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTIALFKAHEVASKRIEEKIQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNIGEDAELFMALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQIVRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIHGKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKELQASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLFCKFIQSIPDNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIALLQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEAAYTLLLHAELLQWSDKPCVPHLLQKDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLPPSYKDKPVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHERLSSCFRELKEKVEKHYGVITLPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVVSTSSNSSDNAPSRPGSDGSILEPLLERRASSGARVEDLSLREENSENRISKFKRKDWSLSKSQVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLSPFHGSSPPQSTPLSPPPLTPKATRTLSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLPVRREAKAPPPPPPKARKSGIPTSEPGSQ
Protein: Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2'] (P11224)
Organism: Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus)
Function: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Interacts with murine CEACAM1 to mediate viral entry.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04099}. Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000255|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04099}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04099}. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. {ECO:0000255|HAMAP-Rule:MF_04099}.
Interaction partners:
Sequence:
MLFVFILFLPSCLGYIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVSLSWFQPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGNKLIGFWHTDVKPPICVLKRNFTLNVNADAFYFHFYQHGGTFYAYYADKPSATTFLFSVYIGDILTQYYVLPFICNPTAGSTFAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSMLPSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLFCNNIDASKVYGRCFGSISVDKFAVPRSRQVDLQLGNSGFLQTANYKIDTAATSCQLHYTLPKNNVTINNHNPSSWNRRYGFNDAGVFGKNQHDVVYAQQCFTVRSSYCPCAQPDIVSPCTTQTKPKSAFVNVGDHCEGLGVLEDNCGNADPHKGCICANNSFIGWSHDTCLVNDRCQIFANILLNGINSGTTCSTDLQLPNTEVVTGICVKYDLYGITGQGVFKEVKADYYNSWQTLLYDVNGNLNGFRDLTTNKTYTIRSCYSGRVSAAFHKDAPEPALLYRNINCSYVFSNNISREENPLNYFDSYLGCVVNADNRTDEALPNCDLRMGAGLCVDYSKSRRAHRSVSTGYRLTTFEPYTPMLVNDSVQSVDGLYEMQIPTNFTIGHHEEFIQTRSPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVASALMQGVTISSRLPDGISGPIDDINFSPLLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGYTTGATAAAMFPPWSAAAGVPFSLSVQYRINGLGVTMNVLSENQKMIASAFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALNAYISKQLSDSTLIKVSAAQAIEKVNECVKSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISGDRGLAPKAGYFVQDDGEWKFTGSSYYYPEPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAPDLSLDFEKLNVTLLDLTYEMNRIQDAIKKLNESYINLKEVGTYEMYVKWPWYVWLLIGLAGVAVCVLLFFICCCTGCGSCCFKKCGNCCDEYGGHQDSIVIHNISSHED
Protein: NDR1/HIN1-like protein 3 (Q9FNH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Confers resistance to Pseudomonas syringae pv. tomato DC3000 (Pst DC3000).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12913158}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Flotillin-like protein 3
- Calcium ion-binding protein
- RBR-type E3 ubiquitin transferase
- Transmembrane protein
- NEP1-interacting protein-like 1
- At3g62990
- Hyperosmolality-gated Ca2+ permeable channel 2.1
- Hypersensitive-induced response protein 4
- ADP-ribosylation factor C1
- Syntaxin-121
Sequence:
MADLNGAYYGPSIPPPKKVSHSHGRRGGGCGCLGDCLGCCGCCILSVIFNILITIAVLLGIAALIIWLIFRPNAIKFHVTDAKLTEFTLDPTNNLRYNLDLNFTIRNPNRRIGVYYDEIEVRGYYGDQRFGMSNNISKFYQGHKNTTVVGTKLVGQQLVLLDGGERKDLNEDVNSQIYRIDAKLRLKIRFKFGLIKSWRFKPKIKCDLKVPLTSNSTSGFVFQPTKCDVDF
Protein: Rifin (O96292)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKDHYINILLFALPLNILVYNQRNYYITRTPKATTRTLCECELYAPATYDDDPQMKEVMDNFNRQTQQRFHEYDERMKTTRQKCKDQFDKEIQKIILKDKLEKELMDKFATLQTDIQNDAIPTCICEKSLADKVEKTCLRCGSVFGGGITPGWGLISGLGYVGWTNYITEIAIQKGIEAGVKAGIQELKGFAGLSRLINFSEIKNLINHTNYFKEMTYVSFLQDANKTHCSARPTSKEIFCNFVSHNGESALSKRAAGIADYAADMAKITEEGVLEEGASATSSLTTAIIASIIAIVVIILIMIIIYLVLRYLRKKKMKKKLEYIKLLKE
Protein: Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) (Q9NWU2)
Organism: Homo sapiens (Human)
Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:28829046}. Nucleus {ECO:0000269|PubMed:12559565, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. {ECO:0000269|PubMed:28829046}.
Interaction partners:
- E3 ubiquitin-protein transferase RMND5A
- Armadillo repeat-containing protein 8
- WD repeat-containing protein 26
- Glucose-induced degradation protein 4 homolog
- Muskelin
- Ran-binding protein 9
- Ran-binding protein 10
- E3 ubiquitin-protein transferase MAEA
- E3 ubiquitin-protein transferase RMND5B
- Protein yippee-like 5
Sequence:
MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHTMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK
Protein: Pre-mRNA-splicing factor cwf14 (Complexed with cdc5 protein 14) (O74772)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-processing factor 17
- Pre-mRNA-processing protein 45
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf3
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cwf5
- Pre-mRNA-splicing factor cwf12
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor syf2
Sequence:
MPRLRTSRTKRPPDGFDEIEPTLIEFQDRMRQIENTMGKGTKTEMLAPIFQLHHQRSRYIYDLYYKREAISTELYNWLLKQNYADGNLIAKWKKPGYEKLCCLRCIQTAESKFGSTCICRVPKSKLDKDQRVRCTHCGCNGCASCD
Protein: SCP domain-containing protein (Q9VI17)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLALVVFLIASCLTIQTAATTTPSPAVTEAGHPSPGGSQGQEEPGNSSSTELPDYCDPSLCHKELKHVACNASIELHDKCSLDAELIVISPKVERFLLRRFNELRDSVAKGGFNGLSPASRMGTLKWNPELAYLAEFNVRDCVLRHDECRNTKFTQNAGQTVGYRGIKGKLPELEDILRDIIGVWLREKSRTSMVNIMKYVEQESQSPKYNFLQIVLENAESVGCAIVQQSRHGWIQTFFACNYGHAPVVGSPVYEPGKKAAESCKTGANPKYAHLCAESEVYEKVTPKAGNASSPEIKTRTLGKRDFVMLNGENADGTPPAEGGAPAPAADGAAAAPAAEGGAAAPGEAAATPAVDGAAPGATPGVTPVEGEGSTPAPTAGGTPASESPGGEEAHAEGLLEPMPKPLDRAALEKKFARFLALIKRAEMFHGRRKIVVISSNHEVDDDRVQQEGAEGDATIRTMERAFSRRRAIMRRSIGSHMRSRKPSGFWAPQWIAMP
Protein: Ceramide kinase-like isoform 13 (Ceramide kinase-like isoform 8) (G0XYG8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHIILGHIRSVDVCTFSSAGKLLCFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAIIKALAKLKPEDCKISFLLAGCSQNKQERKSQRSAESDCGGHWQTIQGQFLNISIMAMPCPCSMAPRGFTPDTRLHNGSMALRVVRNTTRSEFVKHLKRHSSVKNQFNFPFVETYIIEEVKIHPKSNSNGYSPQEEGGNHTTASEHGFPWNVDGDLMEAASEVHIRLHPRLIRLYGGSLEEMNDCKVACDCI