wanglab/gogpt-training-data huggingface dataset:
Protein: Ankyrin repeat domain 13, isoform CRA_b (NY-REN-25 antigen) (Q3ZTS7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Late endosome {ECO:0000256|ARBA:ARBA00004603}.
Interaction partners:
Sequence:
MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK
Protein: Signal transducer and activator of transcription (Q1KQ07)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Interleukin-4
- Interleukin-4 receptor subunit alpha
- Tyrosine-protein kinase JAK3
- Interferon regulatory factor 9
- Tyrosine-protein kinase
- Signal transducer and activator of transcription
- Cytokine-inducible SH2-containing protein
- Signal transducer and activator of transcription 1
Sequence:
MSLWSLVSKMSPEKLQRLYVDFPQHLRHLLAEWLENQPWEFLVGSDAFCYNMASALLSATVQRLQASAGEQGKGSSLLQHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFHHLPGPFHRKQEELKFTTALGRLQHRVRETRILRESLQQGTKTAQVSLKNLIDPPANGTGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPLVRADMVTEKQARELSLPQGSGAGVESTGEIMNNTVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFMLGPNKHLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSIEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVAPYDLGMAPDASMQLSSDMVYPPQSHSIHSFQSIPLEESMSVLPPFQEPHLQMPPTMSQISMPFDQPHPQGLLQCQSQEHAVSSPEPLLCSDVTMAEDSCLTQPVQGFPQGTWVSEGMYPPLMPPTEQDLTKLLLEGQGEGGGSIGTQPLLQPSSYGQSGISMSHLDLRTNPSW
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FLW1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MRLYRCFSTFAWVLSWSVTTAKTYQNEELVLDSTVTGDTSFTEAEQLVLDNAKITLKNYSAIHLTSGVILRGNSLLNIETTSGNNVKYSLTINGEVKLDQGSQFIFDGSSLKYSDSKQAYELFNFDINSDENGLFISKDSSMKITVPKLDSIVDGSIDIGSIHIGGTYKAPYNSPIVILGKLEMLSPEQTVDNKYPLKYWRLDLGTDRIDEAGIYKRKNDLSGIISCEGVIGIYADIFSETTDPKIYTLGYIGYSIVSPLTIDLAKGPMIGPSGFLFLNVFPKGQDGIKFVNADLYSPNINDVDTTNMLFSTFYDSSYQHVDIISEQNAITIRSGLDAIATYYSDRHYSIINHCSESSNSIRGRYPSILLSGRTCSVFLTKQQKNSESNGLGSDSNSSIPEQKDETGSIPSGPDMDGGPGPHPGGSDTAGGPGPNPNGSDTAGGPGPNPNGSDTAGGPGPNPNGSDTEGGSGSGGSGSEGGSGEGGSGSGEGGSGGSNPVDDGKDKTTVVTDKDGHVHTDIISHITTTDKDGKPTVILTQYQSPTAVQNGISKTITVDGEEIIEAVHITTYTDSDGHTITSTYTEMFKTLIDAEPQYVGETTQTITTTDTEGHTTTITTTYNIDNNVNTVPIVHSSSNMSSSSSIISSSISSAVSTPSGQDYIITTTGSDGKIETDIVSHITTTVNGKPTTITTTVPCDVSADKDRTTTVTHSNGVIETNVVSHITTTVNGKPTTITTTVPCDVSADKDRTTTVTHSNGVIETNVVSHITTTVNGKPTTITTTVPCDVSADKDRTTTVTHSNGVIETNVVSHITTTVNGKPTTITTTVPCDVSADKDRTTTVTHSNGVIETNVVSHITTTVNGKPTTITTTVPCDVSADKDRTTTVTHSNGVIETNVVSHITTTVNGKPTTITTTTTKLNNAHTTTLTNKDGSVDTKIVVGVTTTNQFGQPVITSITYTPKADSHSNNNVGTVAGTKGAAGNNPSGTNKPQTNPTANAGSNGSSPAANAGSAVVPKAPASNSAAVQQQSSASGTTPGASAAPTIQQINKNAASTLKQTKFCVTIVLTILMNYFLN
Protein: G-protein coupled receptors family 1 profile domain-containing protein (Q8MQ40)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAVASVLLALFMLFLSIVTVIGNLAVLLSYYLDKNIRQPTNYFIFSLAISDLLIGLEGIPVYTAFYLNNNEWIWGDVLCDLWLSIDYIVCLASIYTVLGITVDRYYSVKKPATYRNWRTPGRVVLIIIFIWLVPSILFSVSIFGYGTFTGTGRILKETECYVQFMTNPYLNMGMYISYYWTTLFVMLYLYWGIYRAAKKLALKSDQKTKRLALLTEMRRPEVSVRTSDAGNSSSDSPNDTSNSSK
Protein: Bomanin Short 1 (Bomanin-1) (Immune-induced peptide 1) (DIM-1) (P82706)
Organism: Drosophila melanogaster (Fruit fly)
Function: Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections. Has no activity against the fungus C.glabrata in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:29920489, ECO:0000269|PubMed:9736738}.
Interaction partners:
- Daisho1
- Bomanin Short 2
- Bomanin Short 3
- Bomanin Bicipital 1
- Bomanin Tailed 2
- Bomanin bicipital 2, isoform A
- GNBP-like 3
- Dorsal-related immunity factor Dif
- Embryonic polarity protein dorsal
- demerged
Sequence:
MKFFSVVTVFVLGLLAVANAVPLSPDPGNVIINGDCRVCNVHGGK
Protein: Putative protein ATXN8OS (ATXN8 opposite strand) (Spinocerebellar ataxia 8) (kelch-like 1 antisense) (P0DMR3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24040107}.
Interaction partners:
Sequence:
MPCPGAPCCSLVATGSRVPFSGLKEEEEEDGEDDEEEEEEGFFQKVLTPLLSWLLSRRLWLGPQCSKLPLPSCCRQPPPAGPPVEGDGWLKSFQRSRRMCFTSKSFRPEPDMLYAQKAKGWQLTQDSGGWEVQDQCTRIWSKENLLALNTHSRRQKGKRENKVCVSTWQKSRGDRTYSSMATTPSMTKILEGCMYRKLKC
Protein: DNA repair protein rdl1 (RAD51D-like protein 1) (O13800)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in homologous recombination where it functions at an early stage of recombination in a pre-recombinogenic complex with rlp1 and sws1. Also has a role at a later stage of recombination in association with the rhp55-rhp57 complex.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Zinc finger SWIM domain-containing protein sws1
- DNA repair protein rhp57
- DNA repair protein rlp1
- ATP-dependent DNA helicase hus2/rqh1
- DNA repair protein rad16
- Meiotic recombination protein dmc1
- ATP-dependent DNA helicase fml1
- Mating-type switching protein swi10
- Uncharacterized ATP-dependent helicase C582.10c
- Replication factor A protein 1
Sequence:
MNQVTQFSGNSANLMLYWILKSYYSRFDRIMWIDTLGTFNPAALPLPCLEKTMLVRSFDAQGLKDAVDELESNLKSSEDQAYALCIDSFSNPIGLLMAQGNISFAHAFMMTLGRKCRILTRKFRLAVYLSTSLVYIKQLHLSKPALGNSWPFCLDHSYILEDQQHNKCLVHCNQSRKDLLGCSQLFLLLKGSFTHEYLTIDFYNGTPVSVSSKLHVSPSLYHSSTLNSPS
Protein: Zinc finger CCHC domain-containing protein 2 (Q9C0B9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLRMKLPLKPTHPAEPPPEAEEPEADARPGAKAPSRRRRDCRPPPPPPPPAGPSRGPLPPPPPPRGLGPPVAGGAAAGAGMPGGGGGPSAALREQERVYEWFGLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGPLADFREPAVRSRLIVYLALLGSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAEDERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHPAFSFHQRVTLREHLERLRAALRGGPEDAEVEVEPCKFAGPRAQNNSAHGDYMQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLKGVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFDKTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQSQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDVNLDIGSGHDTCGETSSESYSSPSSPRHDGRESFESEEEKDRDTDSNSEDSGNPSTTRFTGYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVMHNGAQKSEVVVPAPKPADGKTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASPLPIPSTFLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQPPGSLSIASPNTAFIPIHNPGSFPGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPASYPLPGSPLAAGVLPSQNSSVLSTAATSPQPASAGISQAQATVPPAVPTHTPGPAPSPSPALTHSTAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSCGRRCSCGTNGNLQLNSYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDPVMGSQANYGMQQMAGFGRFYPVYPAPNVVANTSGSGPKKNGNVSCYNCGVSGHYAQDCKQSSMEANQQGTYRLRYAPPLPPSNDTLDSAD
Protein: Large ribosomal subunit protein uL18 (60S ribosomal protein L5) (P46777)
Organism: Homo sapiens (Human)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15469983, ECO:0000269|Ref.7}. Nucleus, nucleolus {ECO:0000269|PubMed:15469983, ECO:0000269|Ref.7}. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000269|PubMed:9687515}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL20
- Elongation factor 2
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL3
Sequence:
MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Protein: Stress-activated protein kinase jnk-1 (EC 2.7.11.24) (Q8WQG9)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate some mechanosensory responses, such as response to touch. Independently of jkk-1 and downstream of mek-1, plays a role in resistance to heavy metals, such as Cu(2+) or Cd(2+). Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and arsenite. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals. Downstream of jkk-1 but independently of mek-1, positively regulates lifespan.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10393177}. Perikaryon {ECO:0000269|PubMed:10393177}. Cell projection, axon {ECO:0000269|PubMed:10393177}.
Interaction partners:
- Forkhead box protein O
- Dual specificity mitogen-activated protein kinase kinase mek-1
- Dual specificity mitogen-activated protein kinase kinase jkk-1
- MAP kinase kinase mkk-4
- Tyrosine-protein phosphatase vhp-1
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase
- Transcription factor fos-1
- Ras-related protein rac-2
- Heat shock protein 70
Sequence:
MEERLSTTSSYPSHPGRSVEEDHNTLLASSSISSIIRGTRGHLNNFIESVGNWLVPSSSGRDDDAVSLDSCQSVYSPVRHHINSGTGGGILMEPSSIHVPENYYSVTIGEAQMVVLKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVNHKNIIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIRHLHSAGIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEAFMMTPYVVTRYYRAPEVILGMGYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQPTVRNYVENRPRYQATPFEVLFSDNMFPMTADSSRLTGAQARDLLSRMLVIDPERRISVDDALRHPYVNVWFDEIEVYAPPPLPYDHNMDVEQNVDSWREHIFRELTDYARTHDIYS
Protein: Stardust protein GUK1 isoform (Q8WRS2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRILKQWNRRRSGSSIVVLDGDDLKPCLPDDYISGQHHLNHQQQLQLQQQLQQQHPLQQQHYRTHSGDIREIDQEMLTMLSVNQDNGPHREMAVDCPDTFIARNKTPPRYPPPRPPQKHKKSTNTTTTTTITALTNNDHANKMLIVAYHSSHQHEQLQQQHPSKTSTTTTTIALDVATQNLYNQKQQNKLEQIENYENCLQSERNEQHEQQFEQQKQHQATTAMAATQVAQQQTPSHKLQATLSSDPNGNSNSNNNSHIVGISSSSSSNNSSITDDFLCVVDGLYQGRKDTASPSSSAFDEVMSKHTLDSFGSIAYRHLHQQHQATSNGNSSSNTSNTNSNTNSNTNSNSNTNGNTSNNTAVSTKTATVTKTGVSSSNSNSNSLNSSNSSMHTSSSSSGHSSNIASATSSSSATSSSTVPDDLSLAPPGYXVSQQQQQQHLVATPVTMLLPPMAKHRELPVDVPDSFIEMVKTTPRYPPPAHLSSRGSLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVAAAAVSGVADGDARRVADELNGNAKPVPPPRDHLRVEKDGRLVNCSPAPQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGEAVVIGRIVRGDILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVHNNRDES
Protein: Cerebral cavernous malformation 3 (RE18871p) (Q9VF70)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- non-specific serine/threonine protein kinase
- MOB kinase activator-like 4
- FGFR1 oncogene partner 2 homolog
- CTTNBP2 N-terminal-like protein
- AT25231p
- Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
- Connector of kinase to AP-1, isoform E
- Serine/threonine-protein phosphatase PP2A
- Sarcolemmal membrane-associated protein
- MOB kinase activator-like 3
Sequence:
MTMGEPTSSLVLPVILRPIFSQLERRDVGAAQSLRSAILKSEQNNPGFCYDLVATIVRRADLNVNLNEAVLRLQGKITEADLNEYRLTRTEEPFQELNRKSVALKVILSRIPDEINDRKTFLETIKEIASAIKKLLDVVNEIGSFIPGVTGKQAVEQRKKEFVKYSKKFSTTLKEYFKEGQPNAVFISALFLIRQTNQIMLTVKSKCE
Protein: Trichohyalin-plectin-homology domain-containing protein (Q383H7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Intraflagellar transport protein 57/55
- Intraflagellar transport complex B protein 46 C terminal
- Intraflagellar transport protein 122 homolog
- Intraflagellar transport protein 27 homolog
- Cytoplasmic dynein 2 heavy chain 1
- Cytoplasmic dynein 2 light intermediate chain 1
- Intraflagellar transport protein 140
- Uncharacterized protein
- Uncharacterized protein
- OCRE domain-containing protein
Sequence:
MPLPPVEDAPNSMARRHYLVERNRLRVKKYEPTRQAFEEETVKLSKQRVEQRVAMLNSWKSSVPLHTDTTRPLPGAARRQKEKDEPAAKHINLQILDEDAALKRERRALLRADILQQKKDREEYLAKWRANEKAYDSALLATNAEFARQMQEQERQAAVATKQYMDMMRASNLKELEAKRAKQREKEEADVAALRTMQENLRLKMEADERRAKDMKRLMQIENEENHSLFKKKQAEDKAREDAWIRTMMEHNAALAERERREAEQKRQQFKADFEDTIAKQKEFRRTHDYDEPQELIRKRNEEAAASAVLIRQEERLRNNEQRKQYREELMKQMREKYEWQLSHLDGV
Protein: Glutathione S-transferase U12 (AtGSTU12) (EC 2.5.1.18) (GST class-tau member 12) (Q6NMS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Nucleus {ECO:0000269|PubMed:19174456}.
Interaction partners:
- Glutathione S-transferase L2, chloroplastic
- Glutathione S-transferase DHAR2
- Glutathione S-transferase F5
- Glutathione S-transferase T1
- Glutathione S-transferase F8, chloroplastic
- Glutathione S-transferase TCHQD
- Glutaredoxin family protein
- Putative pectinesterase
- Glutathione S-transferase DHAR1, mitochondrial
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
Sequence:
MLKNKKSDNSLSRDTLQIKKRKKTTMAQNGSNTTVKLIGTWASPFAIRAQVALHLKSVEHEYVEETDVLKGKSDLLIKSNPIHKKVPVLIHGDVSICESLNIVQYVDESWPSDLSILPTLPSERAFARFWAHFVDGKLFESIDAVAGAKDDAARMTLAGNLMENLAALEEAFQKSSKGGDFFGGGNIGFVDITVGAIVGPISVIEAFSGVKFLRPDTTPGLIQWAEKFRAHEAVKPYMPTVAEFIEFAKKKFSV
Protein: Transcriptional regulatory protein ArsR (O24973)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression.
Interaction partners:
- Sensor histidine kinase ArsS
- Sensor histidine kinase CheAY
- Sensor histidine kinase CrdS
- NADH-quinone oxidoreductase subunit
- Sensor histidine kinase FlgS
- NADH-quinone oxidoreductase
- NADH-quinone oxidoreductase subunit J
- NADH-quinone oxidoreductase subunit B
- Chemotaxis protein CheY1
- Delta-aminolevulinic acid dehydratase
Sequence:
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGISAANTQNYDLLLLDLTLPNLDGLEVCRRISKQKHIPIIISSARSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSHKKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEILSLLISKKGYVFSRESIAIESESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY
Protein: DNA repair protein recA homolog 1, chloroplastic (Recombinase A homolog 1) (Q39199)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in recombination ability and DNA strand transfer activity.
Subcellular location: Plastid, chloroplast stroma.
Interaction partners:
- Meiotic recombination protein DMC1 homolog
- DNA repair protein XRCC3 homolog
- DNA repair protein RAD51 homolog 3
- DNA repair protein XRCC2 homolog
- DNA mismatch repair protein MSH1, mitochondrial
- DNA repair protein recA homolog 3, mitochondrial
- Putative DNA repair protein recA homolog 4
- ATP-dependent DNA helicase homolog RECG1, chloroplastic/mitochondrial
- DNA-directed RNA polymerase subunit beta
- Meiotic recombination protein SPO11-1
Sequence:
MDSQLVLSLKLNPSFTPLSPLFPFTPCSSFSPSLRFSSCYSRRLYSPVTVYAAKKLSHKISSEFDDRINGALSPDADSRFLDRQKALEAAMNDINSSFGKGSVTRLGSAGGALVETFSSGILTLDLALGGGLPKGRVVEIYGPESSGKTTLALHAIAEVQKLGGNAMLVDAEHAFDPAYSKALGVDVENLIVCQPDNGEMALETADRMCRSGAVDLICVDSVSALTPRAEIEGEIGMQQMGLQARLMSQALRKMSGNASKAGCTLIFLNQIRYKIGVYYGNPEVTSGGIALKFFASVRLEIRSAGKIKSSKGDEDIGLRARVRVQKSKVSRPYKQAEFEIMFGEGVSKLGCVLDCAEIMEVVVKKGSWYSYEDQRLGQGREKALQHLRENPALQDEIEKKVRLLMLDGEVHRSTPLMSSSSSSASHREEEEEDSLDDFQ
Protein: Protein TRANSPARENT TESTA 9 (Protein GREEN FLUORESCENT SEED 9) (Q8W4P9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in membrane trafficking and vacuole development through membrane fusion at the vacuole. Required for membrane trafficking machinery and accumulation of flavonoids in the seed coat.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:25116949}; Peripheral membrane protein {ECO:0000269|PubMed:25116949}.
Interaction partners:
- Protein SODIUM POTASSIUM ROOT DEFECTIVE 2
- Probable serine/threonine-protein kinase PBL23
- ATPase 10, plasma membrane-type
- Chalcone--flavanone isomerase 1
- Sterol 3-beta-glucosyltransferase UGT80B1
- Reticulon-like protein B8
- Style cell-cycle inhibitor 1
- Amidophosphoribosyltransferase 3, chloroplastic
- Reticulon-like protein B11
Sequence:
MWLSFLRPRDRFSLAELRYLTDQLRKIQIVNEANKDLVIEALRSIAEILTYGDQHDPLFFEFFMEKQVMGEFVRILRVSKTVTVSVQLLQTMSIMIQNLKSEQAIYYLFSNEYVNYLITYTFDFQHEELLSYYISFLRAVSGKLNKHTISLLLKTENDVVVSFPLYVEGIQFAFHEENMIRTAVRALTLNVYHVGDESVNDYVVSPPHTEYFSKLISFFQKQCMDLSAMVLNTLKSPSPDSGGKLFSAVDGIEDTLYYFSDVISAGIPDIGRLITDHILQHLTLPLLLPSLCSEAVNDISVDPVTSLYLLSCILRIVKIKDLANMTAATLFCPVKAFISSSLVKPNSSLAPEGLTYVNGHPDKGVTEEANQQCSSTAAGMSDDGNSHLCSEDTPKSIFNNSHMTFRETLLQYISEGDDVQAQGSLFVLATLLQTKELEESMLDAFGILPQRKQHKKLLLQSLVGEDTGEEQLFSPRNGSMRDGLSSELDWYLRRLEEQFGVCCSLPGAARCPRVHRHQVVDTLVTLLCRENISAETLWDGGWLLRQLLPYSEAEFNRKHLKMLNVSYEKCKNSLTREIKGIWPDLLIRVLLDEWRKCKRVIEAPSPQKEPKSVLLQLDRSSSNDNSVSESSFTAGERMCEVVKVFVLLHQLQIFSLGRSLPEQPPIYPPADRSETSRATRAGLDVSVPKPGTELKLVDAVPCRIAFERGKERDFSFLALSSGESGWIVLADPDNGIVRVTAPLAGCKPRIDEKHPRWLHLRIRPSTLPLLDPTKRGVYEKLKSKGLVDGRWILAFRDDESCHSAYSMVAGEIDLQCSEVERRLRPLFDLERNQLEDQ
Protein: Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4) (Q8CGQ8)
Organism: Mus musculus (Mouse)
Function: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:26247047}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:26247047}.
Interaction partners:
- Thioredoxin domain-containing protein 3
- Cas scaffolding protein family member 4
- Ras and Rab interactor 3
- ATP-binding cassette sub-family A member 7
- WD repeat-containing protein 72
Sequence:
MALRGLIRQSKVRRRREMLPQQVGFVCAVLALVCCASGLFGSLGHKTASAGKHVLLDTWRNRKLMAPINGTPLAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMKYNMKMQTFFTTKQKSIANGNPVSNELEDGNDLYDGSYDDPSVPLLGQVKEKPPYGKTPVVMVDEILSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVNSKPLQNGRHENMENGNVPVENPEDPQQGQEQQPPPQPPPPEPESVETVFLSPFSMPEAKGDKAKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCFSIMIEFNVFTFVNLPMCREDD
Protein: DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) (Q9CWP8)
Organism: Mus musculus (Mouse)
Function: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9HCU8}. Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. {ECO:0000250|UniProtKB:Q9HCU8}.
Interaction partners:
- DNA polymerase delta catalytic subunit
- DNA polymerase delta subunit 3
- DNA polymerase delta subunit 2
- DNA polymerase epsilon subunit 4
- DNA polymerase epsilon subunit 2
- DNA polymerase epsilon subunit 3
- DNA polymerase epsilon catalytic subunit A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
- Mitotic spindle assembly checkpoint protein MAD2B
- DNA polymerase zeta catalytic subunit
Sequence:
MGRKRFITDSYPVVKKREGPPGHSKGELAPELGEDTQSLSQEETELELLRQFDLAWQYGPCTGITRLQRWSRAEQMGLKPPLEVYQVLKAHPEDPHFQCSLWHLYPL