wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium-dependent high-affinity dicarboxylate transporter 2 (H9G2P8)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKLNFLAACMKKLFRFNYGTNNTRYHVLPLSDEGMKPSPQRTLIKKLLVLLGPLVAVPLLFFGPEYRCLFSIIFLSTYWIGEAFPIGVTSLFPLALYPILQIVPSKQISPVYFKDSIVLFMCTLIMAMAVEATGLHRRIALKLLTKVGAKQPVMLLGFMCITSFISFFVSDTACTALMCPTAVALLMSMSDAVQHLKEDHRKPKPPPDDATVAEKLRIDDMTPQDAGFCKALILACAHASLIGGTAIITSTGPNLVFRENIHKRYPEGQVTMTYLQWMVFAIPPMFVYLLASYIILVCYFMGPSTFARWFERPSKEEAHLKKLIEKNIQTMYEDLGDVSWGEKSVFVFFILLIGSWISRDPGFTPGWGDLLPHRNFISDSVSGVLISCILFVWPKDPFDPIDPMAPILKWTDMKSKFSWSCTLLIGAGYAISEGVDKSGLSRLISCGMKNIFVGMSSLPLQLTVTTIIVIMTEFASNVSTGSIFIPISLGVAESMGVHPLYLALPTTVACSFAFMLPISTPPNAVVYDTKVISMVEMIVCGFLLNIACILITSLNMNTWTYFIFSLNIFPENIVISSENSSYPVC
Protein: Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Osmotic stress-induced proline dehydrogenase) (Proline oxidase) (Protein EARLY RESPONSIVE TO DEHYDRATION 5) (P92983)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts proline to delta-1-pyrroline-5-carboxylate.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:20403182, ECO:0000269|PubMed:9847097, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial
- Pyrroline-5-carboxylate reductase
- Ornithine aminotransferase, mitochondrial
- Delta-1-pyrroline-5-carboxylate synthase A
- Delta-1-pyrroline-5-carboxylate synthase B
- Urea-proton symporter DUR3
- Proline dehydrogenase 2, mitochondrial
- Proline iminopeptidase
- Probable prolyl 4-hydroxylase 4
- Probable prolyl 4-hydroxylase 10
Sequence:
MATRLLRTNFIRRSYRLPAFSPVGPPTVTASTAVVPEILSFGQQAPEPPLHHPKPTEQSHDGLDLSDQARLFSSIPTSDLLRSTAVLHAAAIGPMVDLGTWVMSSKLMDASVTRGMVLGLVKSTFYDHFCAGEDADAAAERVRSVYEATGLKGMLVYGVEHADDAVSCDDNMQQFIRTIEAAKSLPTSHFSSVVVKITAICPISLLKRVSDLLRWEYKSPNFKLSWKLKSFPVFSESSPLYHTNSEPEPLTAEEERELEAAHGRIQEICRKCQESNVPLLIDAEDTILQPAIDYMAYSSAIMFNADKDRPIVYNTIQAYLRDAGERLHLAVQNAEKENVPMGFKLVRGAYMSSEASLADSLGCKSPVHDTIQDTHSCYNDCMTFLMEKASNGSGFGVVLATHNADSGRLASRKASDLGIDKQNGKIEFAQLYGMSDALSFGLKRAGFNVSKYMPFGPVATAIPYLLRRAYENRGMMATGAHDRQLMRMELKRRLIAGIA
Protein: Nitrite transporter (A0A0H2Z3A5)
Organism: Escherichia coli O1:K1 / APEC
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFTDTITKCAANAARIARLSANNPLGFWVSSAMAGAYVGLGIILIFTLGNLLDPSVRPLVMGATFGIALTLVIIAGSELFTGHTMFLTFGVKAGTISHGQMWAILPQTWLGNLVGSVFVAMLYSWGGGSLLPVDTSIVHSVALAKTTAPAMVLFFKGALCNWLVCLAIWMALRTEGAAKFIAIWWCLLAFIASGYEHSIANMTLFALSWFGNHSEAYTLAGIGHNLLWVTLGNTLSGAVFMGLGYWYATPKANRPVADKFNQTETAAG
Protein: F-box/LRR-repeat MAX2 homolog (F-box and leucine-rich repeat MAX2 homolog) (Protein DWARF 3) (Q5VMP0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in strigolactone (SL) signaling. Required for responses to SLs and the establishment of arbuscular mycorrhiza symbiosis in rice. Strigolactone-dependent association of D3 with D14 and D53 (a repressor of SL signaling) triggers D53 ubiquitination and degradation. Controls tillering by suppressing axillary bud activity. Tiller is a specialized grain-bearing branch that is formed on the unelongated basal internode and grows independently of the mother stem (culm) by means of its own adventitious roots.
Subcellular location: Nucleus {ECO:0000269|PubMed:24616269}.
Interaction partners:
Sequence:
MAEEEEVEEGRSSSSAILDLPEPLLLHILSFLTDVRSRHRAALACGRMRAAERATRSELSLRGDPRSPGFLFLSHAFRFPALEHLDLSLVSPWGHPLLSSVPPCGGGGGGAPSASSSSGMNVYHPEAISEQNAFIAARLAGCFPAVTSLAVYCRDPTTLANLTPHWQASLRRVKLVRWHQRPPTLPDGADLEPLLETCAALRELDLSEFYCWTEDVVRALTTHPSATAALTHLDLGLAAATDGFKSSELGPIAASCPNLRKLVAPCLFNPRFSDCVGDDALLSLATSCPRLTVLRLSEPFEAAANIQREEAAITVAGLVAFFAALPALEDFTMDLQHNVLEAAPAMEALARRCPRIKFLTLGSFQGLCKASWLHLDGVAVCGGLESLYMKNCQDLTDASLAAIGRGCRRLAKFGIHGCDLVTSAGIRRLAFTLRPTLKEVTVLHCRLLHTAECLTALSPIRDRIESLEINCVWNTTEQPCSVANGTTTECDPEDDELGEVYESAAKKCRYMEFDDLGSWEMLRSLSLWFSAGQLLSPLISAGLDSCPVLEEISIKVEGDCRTCPRPAPRTIFGLSDLAGFPVLAKMKLDLSEAVGYALTAPTGQMDLSLWERFYLHGIESLQTLYELDYWPPQDKDVHHRSLTLPAVGLIQRCVGLRKLFIHGTTHEHFMTFFLSIPNLRDMQLREDYYPAPENDLMFTEMRAESWLRFEVQLNSRQIDD
Protein: NAC domain-containing protein 3 (ANAC003) (Q5PP28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Dymeclin
- NAC domain protein
- At5g65925
- NADH dehydrogenase iron-sulfur protein 5-B
- Holliday junction resolvase
- Pathogenesis-related thaumatin superfamily protein
- Peter Pan-like protein
- Pathogenesis-related thaumatin superfamily protein
- NAC domain containing protein 84
- Transcription factor MYB108
Sequence:
METPVGLRFCPTDEEIVVDYLWPKNSDRDTSHVDRFINTVPVCRLDPWELPCQSRIKLKDVAWCFFRPKENKYGRGDQQMRKTKSGFWKSTGRPKPIMRNRQQIGEKKILMFYTSKESKSDWVIHEYHGFSHNQMMMTYTLCKVMFNGGMREKSSSSPSSSGVSGIEQSRRDSLIPQLVNNSEGSSLHREDPSQFGDVLQEAPIEDAKLTEELVKWLMNDEDDAQIEDAIPIEEWETWLNDIDDAKEKSIMFMHDNRSDYRPPNSLTGVFSDDVSSDDNDSDLLTPKTNSIQTSSTCDSFGSSNHRIDQIKDLQESPTSTINLVSLTQEVSQALITSIDTAEKKKNPYDDAQGTEIGEHKLGQETIKKKRAGFFHRMIQKFVKKIHLCSSISRT
Protein: Beta-hexosaminidase (EC 3.2.1.52) (H3BS10)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLR
Protein: TBC1 domain family member 7 (Cell migration-inducing protein 23) (Q9P0N9)
Organism: Homo sapiens (Human)
Function: Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:24529379}. Cytoplasmic vesicle {ECO:0000269|PubMed:17658474}. Cytoplasm, cytosol {ECO:0000269|PubMed:24529379}. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with the TSC-TBC complex (PubMed:17658474). Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients (PubMed:24529379). In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol (PubMed:24529379). {ECO:0000269|PubMed:17658474, ECO:0000269|PubMed:24529379}.
Interaction partners:
- Hamartin
- Tuberin
- GTP-binding protein Rheb
- RAC-alpha serine/threonine-protein kinase
- Ubiquitin carboxyl-terminal hydrolase 6
- Ribosomal protein S6 kinase alpha-1
- 14-3-3 protein zeta/delta
- DNA damage-inducible transcript 4 protein
- Ribosomal protein S6 kinase alpha-2
- RAC-gamma serine/threonine-protein kinase
Sequence:
MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHAKVMMYRKEQYLDVLHALKVVRFVSDATPQAEVYLRMYQLESGKLPRSPSFPLEPDDEVFLAIAKAMEEMVEDSVDCYWITRRFVNQLNTKYRDSLPQLPKAFEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSS
Protein: aspartate--tRNA ligase (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (Q38CB4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Tyrosyl/methionyl-tRNA synthetase, putative
- proline--tRNA ligase
- aspartate--tRNA ligase
- Structure-specific endonuclease subunit SLX1 homolog
- leucine--tRNA ligase
- arginine--tRNA ligase
- glutamate--tRNA ligase
- glutamine--tRNA ligase
- isoleucine--tRNA ligase
- Amidase domain-containing protein
Sequence:
MYRFWPSFSPFPTLKLLNIHRWCCSATGKPPMVGVAAIQRGALQSAASARVRGRVENFRVRGKLAFIQLRQPPSHSIQVVAAGAEISHKVKELTPESIVDVIGVIKPTERPVTSVSCSNYELHATSIEVVSKAAVPLPFPLHDQNAKLDTRLNNRYIDMRTPLAVAMIRLVSAAAQSFRTQLLSRDFVELHTPKIIGTASEGGSALFSLDYFGRQAFLAQSPQLYKQMAIMGDGMRVFEIGPVFRAEKSLTHRHLTEFTGLDAEFTVDEFYTELLDVLESILCGMIWKLQTENAEWISQARAALMELDSTEDCGTVVPRREDIVCEVAEEIIAMYNIRFDDAASRIAPSVPTEPSEDRYHARIGTSGPKVLRMTFRDALQLIRDNDHQHAGRQQEVVGESDEEVVVDFNLNQERALGELIRLRYGVDLYVVDQFPLAARPFYTMPHPSEEGVACGFDMYLRGEEICSGGQRIHDVAQLIHSMEQRRMEAAHMRDYVDSFRYGAWPHGGFGLGLERIVLFLLGARDIRRVSLFPRDPRRLAP
Protein: GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2) (P70425)
Organism: Mus musculus (Mouse)
Function: Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.
Subcellular location: Nucleus {ECO:0000269|PubMed:23805044}. Cell membrane {ECO:0000269|PubMed:23805044}. Note=Colocalizes with PLXNB3 at the plasma membrane. {ECO:0000250|UniProtKB:Q99578}.
Interaction partners:
- Synaptotagmin-4
Sequence:
MEVENEAHCCPGSSSGGSREYKVVMLGAGGVGKSAVTMQFISHQFPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGMNLARDYNCAFFETSAALRFGIDDAFQGLVREIRRKESMLSLVERKLKRKDSLWKKIKASLKKKRENML
Protein: Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) (Q9HD26)
Organism: Homo sapiens (Human)
Function: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes.
Subcellular location: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}.
Interaction partners:
- Rho-related GTP-binding protein RhoQ
- Cystic fibrosis transmembrane conductance regulator
- Syntaxin-6
- Proto-oncogene tyrosine-protein kinase ROS
- PRKCA-binding protein
- Membrane cofactor protein
- Golgin subfamily A member 3
- Beclin-1
- Na
- Spermatogenesis-associated protein 16
Sequence:
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Protein: Uncharacterized protein (Q57ZV9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRFVSRSGCLNTVPYNKLRPSCCARRSFVRVANPAEERGTTQRYQTLGEYLQRLPRGLRDVLLWSPAIAAAYFMFYKQPTYYLPSARRRLLSRPVASTPKSKAEKSRSGGVVSIRLDDPSGAVVKGVVLAVLDADGTTLESCVNSASSPSPPVPPFIVGITDCLMRLQMVREPETGKVKGYTLV
Protein: Transporter (Q8MZA1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MANNQPPTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVSSPCWVFSLKNRAYPWNRWPLEELDWPSSRIRRPLPCCLSRSSGRSCFSLCSFCWASTVCLYNWRPSCHRYWMSGIG
Protein: ATP-dependent Clp protease ATP-binding subunit ClpC (Q2G0P5)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit
- Adapter protein MecA
- Protein-arginine kinase
- Chaperone protein DnaK
- Transcriptional regulator CtsR
- Protein-arginine kinase activator protein
- Co-chaperonin GroES
- ATP-dependent Clp protease ATP-binding subunit ClpX
- Protein GrpE
- Chaperone protein DnaJ
Sequence:
MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLESFNITEDKVIEEVEKLIGHGQDHVGTLHYTPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGNPEMSNKNAQASKSNNTPTLDSLARDLTVIAKDGTLDPVIGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKDKRVMSLDMGTVVAGTKYRGEFEERLKKVMEEIQQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKNIEKDAALERRFQPVQVDEPSVVDTVAILKGLRDRYEAHHRINISDEAIEAAVKLSNRYVSDRFLPDKAIDLIDEASSKVRLKSHTTPNNLKEIEQEIEKVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEEAKNEWKNAQNGMSTSLSEEDIAEVIAGWTGIPLTKINETESEKLLSLEDTLHERVIGQKDAVNSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESMFGDDDAMIRVDMSEFMEKHAVSRLVGAPPGYVGHDDGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLTDTKGRTVDFRNTIIIMTSNVGAQELQDQRFAGFGGSSDGQDYETIRKTMLKELKNSFRPEFLNRVDDIIVFHKLTKEELKEIVTMMVNKLTNRLSEQNINIIVTDKAKDKIAEEGYDPEYGARPLIRAIQKTIEDNLSELILDGNQIEGKKVTVDHDGKEFKYDIAEQTSETKTPSQA
Protein: Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa) (O00461)
Organism: Homo sapiens (Human)
Function: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.
Interaction partners:
- Syntaxin-5
- Golgin subfamily A member 5
- Golgi SNAP receptor complex member 1
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 8
- Golgi phosphoprotein 3
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 2
Sequence:
MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM
Protein: Krueppel-like factor 14 (Q19A41)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Coatomer subunit gamma-2
- Paired amphipathic helix protein Sin3a
Sequence:
MSAAVACLDYFAAECLVSMSTRAVLHRRATDPEGASAAAVSEVGAVSRESAGKGTGSRGVLWIPPVLQVPTPSPGEGDGAPHLLAASALADLSCGAREDFREDSEEAPCASTSCFEPTWCSSPTGGSEPTQAFFEDELSDAESSCSDSAILDAPEASEEPDDSGEVPEGPPGARPAPSTGPTYRRRQITPASKRHQCSFHGCNKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKRFSCPLCPKQFSRSDHLTKHARRHPTYHPDMIEYRGRRRTPRPEPPPPAMVESSGSDSSSSSGQETSFTACL
Protein: Double C2-like domain-containing protein beta (Doc2-beta) (P70610)
Organism: Rattus norvegicus (Rat)
Function: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
Subcellular location: Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner.
Interaction partners:
- Syntaxin-4
- Rab effector Noc2
Sequence:
MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAPARSPAATAGPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPVRPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNEIPGAVLSD
Protein: Uncharacterized protein (Q57W68)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTTATVKPEIVIAVLSMCGLLTVVVIILLVCSWWSRRKAGAYAGSALYRGFKRRHQFELVCTPGPGAHAAPLEVQLRTSHVDPCDILVDVQYTPPGFLKECDRTAVSPARLLGADEHYGEQYLLYSHPFVFRGPGRYTVNAHTVSPSMRYVGAVHNFCFDVLPGDTPSGSGDTEMEASCQHANDFSRHDFSTQRDVATKCSITPIRHPLPPRIIPNEGEVTTFTPIIITTNNESTTADQIRYSVDGRYPSLLYTGPFTLSVPPFSNACNGSSVPVVVRAVAVSGSDTGLTSEVVTANFTVYRAGHSFFDPQVPAPVARVHAVNAKLYFDESRRPPNTNILYQLVYVSEARQKPKFSRRRGFVYTGEFVPLREDVAFIYAWTFVGDGNGDGTGVDLDEVNGGGRRHIRSSAAVYDCRRGTSWNREARDEGGLHPHNNDRTHRGDLSPPVICVSCSEMEVFFEDPPAGGVVCYTLDRTEPAAPGGATAPEQAVRVGLGTGAQQLARFGPGPNLSTYVYKSNQPIHVTLLQTEQVFVTARTFIPVADGAAGDAVTCYRFSDRFFRGFAIQ
Protein: Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) (O95218)
Organism: Homo sapiens (Human)
Function: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.
Subcellular location: Nucleus {ECO:0000269|PubMed:11448987}.
Interaction partners:
- U1 small nuclear ribonucleoprotein 70 kDa
- Serine/arginine-rich splicing factor 11
- Splicing regulatory glutamine/lysine-rich protein 1
- Splicing factor U2AF 35 kDa subunit
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Luc7-like protein 3
Sequence:
MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK
Protein: Spindle-defective protein 2 (P91870)
Organism: Caenorhabditis elegans
Function: Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15068791, ECO:0000269|PubMed:15186742}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15186742, ECO:0000269|PubMed:19081077}. Note=Localizes to the centriole throughout the cell cycle and accumulates on the PCM during mitosis (PubMed:15068791, PubMed:15186742). Requires spd-5 for its accumulation on the PCM (PubMed:15068791, PubMed:15186742). Recruitment to the centrosome during prophase of the 1-cell embryo is regulated by the cye-1/cdk-2 complex (PubMed:17115027). {ECO:0000269|PubMed:15068791, ECO:0000269|PubMed:15186742, ECO:0000269|PubMed:17115027}.
Interaction partners:
- Nsp1_C domain-containing protein
- Spindle-defective protein 5
- Probable serine/threonine-protein kinase zyg-1
- Serine/threonine-protein kinase plk-1
- Spindle assembly abnormal protein 6
- Spindle assembly abnormal protein 4
- Nuclear Pore complex Protein
- Nuclear pore complex protein 5
- Nucleoporin_N domain-containing protein
- Nuclear pore complex protein Nup85
Sequence:
MEDDAPMNLCNEQFEEIEDSPIDDNDNESFYNADGDVELEEEEVHETPKNFKNGGRFKTNMTNPKVNDLTTIEEKNEDLRSAASSRSASRPASVMSDKSFSSQFEFQSGGENAIEEYTNQVFADENKADLLFPETSKFMNGASPPKDKHHSWEPSIHHYDKQPPPDIQTNSPVFGNLNHRKNKLIPQARAKPGANDNEIVERDNDENVPTTSDKSAFITSPMNSTNHDEKTSTPKRPTNRKIGQYQGPNFDLSSIYVGSPQHQNTSISTGQQMPTSSYSHAHSETMMTNQTINESMVRRVLNGNNKNQDLFAALEEARKRRAAQPSKPDFRINTTRTRVPIKPTSARHSGNVVSSTSNDNTTAASSKDLTTSRKAMETFRQNASMADATNSNTASMTSILSTISTARTDISRSSRNHGGGFSNTSVSTVIPANNGNVSLSHGRDGRDSVSSVRTMSRASSTSTVYAGSTFSGVSKPLRIHAKRVAFGCVAVGETLRVEVEVENISDRQCLVRASTDSTTPVYQILDNKLTMVDPKKSIKFQVSFSPSSVGRYQVIMSIEVPAQNFIHKIPMWGNGGIAKFVPTSPDLQQTINQSEYAMCTSCAKRISFKISNSAGTRDGFAMIKVFDSAMRQLPDGCVAFFPAPGFIVKKKSDKRVDIRIDSSYIDLHDENNFRTSSSLSTASTTSSFQRRILPGAKFFVHVVWGEETMRTRLRLLEVRTGQHQLIDGHDFTSFQFSDEEVLRAVPVGFPAIKPEDRDLFAASYRSFFINFFTSTTEFRAATSRKKKEICSNDDSTLLETTAFRNQTFVNDVTIVPNTRFSNRK
Protein: Late cornified envelope protein 1E (Late envelope protein 5) (Q5T753)
Organism: Homo sapiens (Human)
Function: Precursors of the cornified envelope of the stratum corneum.
Interaction partners:
- Late cornified envelope protein 1D
- Late cornified envelope protein 1B
- Late cornified envelope protein 1C
- Late cornified envelope protein 1F
- Late cornified envelope protein 2C
- Late cornified envelope protein 1A
- Late cornified envelope protein 2D
- Late cornified envelope protein 2B
- Late cornified envelope protein 3B
- Late cornified envelope protein 3D
Sequence:
MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRHHRSHRHRPQSSDCCSQPSGGSSCCGGGSGQHSGGCC
Protein: LysM domain-containing GPI-anchored protein 2 (Chitin elicitor-binding protein LYM2) (CEBiP LYM2) (O23006)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chitin elicitor-binding protein involved in the perception of chitin oligosaccharide elicitor.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Protein LYK2
- Chitin elicitor receptor kinase 1
- Protein LYK5
- Plasmodesmata-located protein 5
- At5g62150
- LysM domain receptor-like kinase 3
- At4g25433
- Plasmodesmata-located protein 1
- At3g52790
- Ankyrin repeat-containing protein At5g02620
Sequence:
METSCFTLLGLLVSLSFFLTLSAQMTGNFNCSGSTSTCQSLVGYSSKNATTLRNIQTLFAVKNLRSILGANNLPLNTSRDQRVNPNQVVRVPIHCSCSNGTGVSNRDIEYTIKKDDILSFVATEIFGGLVTYEKISEVNKIPDPNKIEIGQKFWIPLPCSCDKLNGEDVVHYAHVVKLGSSLGEIAAQFGTDNTTLAQLNGIIGDSQLLADKPLDVPLKACSSSVRKDSLDAPLLLSNNSYVFTANNCVKCTCDALKNWTLSCQSSSEIKPSNWQTCPPFSQCDGALLNASCRQPRDCVYAGYSNQTIFTTASPACPDSAGPDNYASTLSSSFNFVIVLIQCALLCLCLL