wanglab/gogpt-training-data huggingface dataset:
Protein: Phospholipase A and acyltransferase 1 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (A0A0R4IY06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:33854238}. Mitochondrion membrane {ECO:0000269|PubMed:33854238}; Single-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:33854238}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:33854238}; Single-pass membrane protein {ECO:0000305}. Note=During eye lens differentiation, recruited from the cytosol to various organelles, including mitochondria, endoplasmic reticulum and lysosomes, immediately before organelle degradation. This translocation is triggered by organelle membrane damage and requires the C-terminal transmembrane domain. {ECO:0000269|PubMed:33854238}.
Interaction partners:
- Family with sequence similarity 84, member A
- LRAT domain containing 2
- DnaJ homolog subfamily C member 10
Sequence:
MDNQQRRTDNMASGETDHLQCVEEPQPGDLIEIFRPAYQHWALYLGDGYIINLTPVDEGQATAVSSVKSVFSRKAVVRMQLLKEVVGADSYRINNKYDDDHTPLPVSEIIQRAQMLIGQEVSYDLLGSNCEHFVTLLRYGEGVSEQASRAIGAISLVTAAASAFSVLGLINTRSRNRPF
Protein: Ahnak protein (Q8CGE7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
VPSVGLEGPNIDLQGPEGKIKFPKFSLPKISAPGVKMEGGSTEIGAQMPSLEGGLSTSDMKLEGPHLSLKGPGVDLPSVDLSMPKVSGPDLDMNLKGPSLKGDLGASSPSMKLHAPGLDLKGVGGKVHIGADGVKMSGIDATTALSVGAPDVTLKGPSLQGDLAVSGDIKCPKVSVATPDVSLEASEGAVKLPHMKLPQFGISTPGSDLDINIKGPQVCGELKGSGMDVNLKGPQISAPSMDFNLEGPKVKGSLGAAGELKGPAIGGALPGISIQGPEGNLQMPGIKASGCDVKLSSGQISGPEIKGDLKGSGLGLHGAVPDIGVKGPSFNVASPESDFGVSLKGPKVKGGVDVSGGVSVPDINLGEGHMSVKGSGVEWKGPQVSSSLNLDTSKLAGNLHFSGPKIEGDVKGGQTGLQGPGLSVSGPQGHLESESGKVTFPKMKIPKFTFSGRELIGREVGVDVNFPKVEANVQAGAGEGKWEESEVKLKKSKIKMPKHIFSKSKGKGGVTGSPEASISGSKGDLKSSKASLGSVEGEVEAEASSPKGKFSLFKSKKPRHRSNSFSDEREFSAPSTPTGTLEFAGGDAKGKHGKLKFGTFGGLGSKSKGHYEVTGSDDEAGKLQGSGVSLASKKSRLSSSSSNDSGTKVGIQLPEVELSVSTKKE
Protein: Zinc finger protein 652 (Q9Y2D9)
Organism: Homo sapiens (Human)
Function: Functions as a transcriptional repressor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein CBFA2T3
Sequence:
MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYSVLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVEVNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKNSSAQHH
Protein: Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (Protein CORYMBOSA 2) (Protein HUA ENHANCER 1) (S-adenosylmethionine-dependent RNA methyltransferase HEN1) (Q9C5Q8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methyltransferase that adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs). This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation. Can methylate 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs). Involved in plant development through its role in small RNAs processing. Required for the specification of reproductive organ identities and the probable repression of A class genes. May control floral determinacy possibly by regulating the expression of the C class floral homeotic gene AGAMOUS (AG).
Subcellular location: Nucleus {ECO:0000269|PubMed:15024409}.
Interaction partners:
- Endoribonuclease Dicer homolog 1
- Double-stranded RNA-binding protein 1
- Endoribonuclease Dicer homolog 3
- Dicer-like protein 4
- Protein argonaute 1
- RNA-dependent RNA polymerase 2
- RNA-dependent RNA polymerase 6
- Protein HASTY 1
- Protein DCL homolog, chloroplastic
- Endoribonuclease Dicer homolog 2
Sequence:
MAGGGKHTPTPKAIIHQKFGAKASYTVEEVHDSSQSGCLGLAIPQKGPCLYRCHLQLPEFSVVSNVFKKKKDSEQSAAELALDKLGIRPQNDDLTVDEARDEIVGRIKYIFSDEFLSAEHPLGAHLRAALRRDGERCGSVPVSVIATVDAKINSRCKIINPSVESDPFLAISYVMKAAAKLADYIVASPHGLRRKNAYPSEIVEALATHVSDSLHSREVAAVYIPCIDEEVVELDTLYISSNRHYLDSIAERLGLKDGNQVMISRMFGKASCGSECRLYSEIPKKYLDNSSDASGTSNEDSSHIVKSRNARASYICGQDIHGDAILASVGYRWKSDDLDYDDVTVNSFYRICCGMSPNGIYKISRQAVIAAQLPFAFTTKSNWRGPLPREILGLFCHQHRLAEPILSSSTAPVKSLSDIFRSHKKLKVSGVDDANENLSRQKEDTPGLGHGFRCEVKIFTKSQDLVLECSPRKFYEKENDAIQNASLKALLWFSKFFADLDVDGEQSCDTDDDQDTKSSSPNVFAAPPILQKEHSSESKNTNVLSAEKRVQSITNGSVVSICYSLSLAVDPEYSSDGESPREDNESNEEMESEYSANCESSVELIESNEEIEFEVGTGSMNPHIESEVTQMTVGEYASFRMTPPDAAEALILAVGSDTVRIRSLLSERPCLNYNILLLGVKGPSEERMEAAFFKPPLSKQRVEYALKHIRESSASTLVDFGCGSGSLLDSLLDYPTSLQTIIGVDISPKGLARAAKMLHVKLNKEACNVKSATLYDGSILEFDSRLHDVDIGTCLEVIEHMEEDQACEFGEKVLSLFHPKLLIVSTPNYEFNTILQRSTPETQEENNSEPQLPKFRNHDHKFEWTREQFNQWASKLGKRHNYSVEFSGVGGSGEVEPGFASQIAIFRREASSVENVAESSMQPYKVIWEWKKEDVEKKKTDL
Protein: Uncharacterized protein C3B8.09 (Q1MTS0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 6
- KRR1 small subunit processome component homolog
- Probable U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar ribonucleoprotein protein mpp10
- Probable U3 small nucleolar RNA-associated protein 18
- Probable nucleolar complex protein 14
- U3 small nucleolar RNA-associated protein 21 homolog
- Uncharacterized protein C57A7.06
- Probable U3 small nucleolar RNA-associated protein 11
- U3 small nucleolar ribonucleoprotein protein imp3
Sequence:
MARKKSRSSSTRKGSSLKVPEIKEKEKINAINTYEDVANSEDEFYNAQDKILFDADNGEQADELELSDEELVALESSSDEEDGNAEENLSENEELSGKKKDAVNEEELYDNKGWGRSAKSYYGGDDYDNEDYSEEDDEFDARMEEQEALRLQRKRLEKVSETDAIDDISQWADNSDLKSIKQDSSAAAIEELVQQISPDLPRTELLKILEAKHPEFQLFLDELNQLKPQLNEIKEKLKTYPSSQLLQAQCTALSTYISFLTFYFALLKDGEEDLKNHPIMVDLVRCKQTWESYCGLDEVLTPTSLEEDGKTIELHEKIASASDIGASEDEEDVDMHESISDNENEGIKDIPVAEDDDITLKFRAAKSKINTNIKNLDDYGEGNRLDDVDAEDKIARKRSLKFYANQIDQKAAKRSRAVLELSGDLDMPYKERRFERQQRLMREAAARGRNQDAGADLDDEDPESMGIPANVDREVEDQDDLDYYESLDKKSKMAKKLRKENHDLERDLIRASRHPELIELGEGDKRGITLDIAKNRGLTPRRPKENRNPRLKKRMRYEKAKKKLASKKAIYKGAPQGGYAGEQTGIKAGLVKSIKLQ
Protein: Hydroxyacylglutathione hydrolase 2, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II) (Q9SID3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Lactoylglutathione lyase
- Lactoylglutathione lyase GLX1
- Probable lactoylglutathione lyase, chloroplastic
- Protein DJ-1 homolog D
- DJ-1 protein homolog E
- DJ-1 protein homolog F
- D-lactate dehydrogenase [cytochrome], mitochondrial
- Monodehydroascorbate reductase 3
- Protein DJ-1 homolog B
- Protein DJ-1 homolog A
Sequence:
MQTISKASSATSFFRCSRKLSSQPCVRQLNIRKSLVCRVMKLVSSPLRTLRGAGKSIRVSKFCSVSNVSSLQIELVPCLKDNYAYILHDEDTGTVGVVDPSEAEPIIDSLKRSGRNLTYILNTHHHYDHTGGNLELKDRYGAKVIGSAMDKDRIPGIDMALKDGDKWMFAGHEVHVMDTPGHTKGHISLYFPGSRAIFTGDTMFSLSCGKLFEGTPKQMLASLQKITSLPDDTSIYCGHEYTLSNSKFALSLEPNNEVLQSYAAHVAELRSKKLPTIPTTVKMEKACNPFLRSSNTDIRRALRIPEAADEAEALGIIRKAKDDF
Protein: Tryptophan N-monooxygenase 1 (EC 1.14.14.156) (Cytochrome P450 79B2) (Tryptophan N-hydroxylase 1) (O81346)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts tryptophan to indole-3-acetaldoxime, a precursor for tryptophan-derived glucosinolates and indole-3-acetic acid (IAA). Involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- L-tryptophan--pyruvate aminotransferase 1
- Tryptophan aminotransferase-related protein 2
- Tryptophan synthase beta chain 1, chloroplastic
- Cytochrome P450 83B1
- Tryptophan synthase alpha chain, chloroplastic
- Tryptophan aminotransferase-related protein 1
- S-alkyl-thiohydroximate lyase SUR1
- Indoleacetaldoxime dehydratase
- Tryptophan N-monooxygenase 2
- Cytochrome P450 71A12
Sequence:
MNTFTSNSSDLTTTATETSSFSTLYLLSTLQAFVAITLVMLLKKLMTDPNKKKPYLPPGPTGWPIIGMIPTMLKSRPVFRWLHSIMKQLNTEIACVKLGNTHVITVTCPKIAREILKQQDALFASRPLTYAQKILSNGYKTCVITPFGDQFKKMRKVVMTELVCPARHRWLHQKRSEENDHLTAWVYNMVKNSGSVDFRFMTRHYCGNAIKKLMFGTRTFSKNTAPDGGPTVEDVEHMEAMFEALGFTFAFCISDYLPMLTGLDLNGHEKIMRESSAIMDKYHDPIIDERIKMWREGKRTQIEDFLDIFISIKDEQGNPLLTADEIKPTIKELVMAAPDNPSNAVEWAMAEMVNKPEILRKAMEEIDRVVGKERLVQESDIPKLNYVKAILREAFRLHPVAAFNLPHVALSDTTVAGYHIPKGSQVLLSRYGLGRNPKVWADPLCFKPERHLNECSEVTLTENDLRFISFSTGKRGCAAPALGTALTTMMLARLLQGFTWKLPENETRVELMESSHDMFLAKPLVMVGDLRLPEHLYPTVK
Protein: Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma (Thymopoietin isoforms beta/delta/epsilon/gamma) (TP beta/delta/epsilon/gamma) (Q61029)
Organism: Mus musculus (Mouse)
Function: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity).
Subcellular location: Nucleus inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Chromosome {ECO:0000250}. Note=Tightly associated with the nuclear lamina. {ECO:0000250}.
Interaction partners:
Sequence:
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLAAGANSKGPPDFSSDEEREPTPVLGSGASVGRGRGAVGRKATKKTDKPRLEDKDDLDVTELSNEELLDQLVRYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTVSSSAENTRQNGSNDSDRYSDNDEDSKIELKLEKREPLKGRAKTPVTLKQRRTEHNQSYSQAGVTETEWTSGSSTGGPLQALTRESTRGSRRTPRKRVETSQHFRIDGAVISESTPIAETIKASSNESLVANRLTGNFKHASSILPITEFSDITRRTPKKPLTRAEVGEKTEERRVDRDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYAPLADVKSEKTKKRRSVPMWIKMLLFALVAVFLFLVYQAMETNQGNPFTNFLQDTKISN
Protein: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) (Q5FVC7)
Organism: Rattus norvegicus (Rat)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
Subcellular location: Endosome membrane {ECO:0000269|PubMed:23572513}; Peripheral membrane protein {ECO:0000269|PubMed:23572513}. Cell membrane {ECO:0000250|UniProtKB:Q15057}.
Interaction partners:
- Ras-related protein Rab-35
- ADP-ribosylation factor 6
- MICAL-like protein 1
Sequence:
MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCAANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDSPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGSESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKLEKMGVKKPQPGQRQEKEAYIRAKYVERKFVDKYSTLLSPSEQEKRIISKSCEDQRLSHTRVSVHTPVKSNDSGIQQCSDDGRESLPSTVSANSLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
Protein: Sialic acid-binding Ig-like lectin 16 (Siglec-16) (Siglec-P16) (A6NMB1)
Organism: Homo sapiens (Human)
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells.
Subcellular location: Membrane {ECO:0000269|PubMed:18629938}; Single-pass type I membrane protein {ECO:0000269|PubMed:18629938}.
Interaction partners:
Sequence:
MLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVAMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLRNGTSLRVLEGQSLRLVCVTHSSPPARLSWTWGEQTVGPSQPSDPGVLQLPRVQMEHEGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVLVAVGEVAMKILLLCLCLILLRVRSCRRKAARAALGMEAADAVTD
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q24326)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MFCFLLVFGVNVVLVHLTTGEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCSSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRLINSMCNSQLSPLSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLETDCLIDVPIKIV
Protein: DNA-directed RNA polymerase I subunit RPA34 (A34) (DNA-directed DNA-dependent RNA polymerase 34.5 kDa polypeptide) (A34.5) (P47006)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase I subunit RPA43
- DNA-directed RNA polymerase I subunit RPA49
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase I subunit RPA135
Sequence:
MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPSNVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQDNLSNMTLLVPSESKESLKIASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDFHVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREKREKKDKKDKKKKHRD
Protein: Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Q7JAI6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Os04g0343050 protein
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome b
- Cytochrome b
- NADH-ubiquinone oxidoreductase chain 4
- Cytochrome b6-f complex subunit 4
- Heme O synthase
Sequence:
MTNLVRWLFSTNHKDIGTLYFIFGAIAGVMGTCFSVLIRMELARPGDQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGAPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGSGTGWTVYPPLSGITSHSGGAVDLAIFSLHLSGVSSILGSINFITTIFNMRGPGMTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSRKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWVGKIFGRTYPETLGQIHFWITFFGVNLTFFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGIRRFFVVVAITSSSGKNKRCAESPWAVEQNPTTLEWLVQSPPAFHTFGELPAIKETKS
Protein: B9 domain-containing protein 2 (Q9N423)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
- B9 domain-containing protein 1
- MecKel-Gruber Syndrome
- NePHronoPhthisis
- Transmembrane protein 231
- Nephrocystin-1-like protein
- Transmembrane protein 107
- CEntrosomal Protein
- Transmembrane protein 237 homolog
- Meckelin
- TMEM
Sequence:
MAEVFVSGQILSARGFGDNRLSIRYQLSFGGGWRVVQGESEGQTQTDCPSVFENAHFAHPIDLHLATSSIQGWPRLLLQIWHHDNYGRQEIAGYGTLLLPTSPGKHVLTSGCWRPKGSWREEMMHKLVGGGLQLTSLSALEDPSIREKIVSVSAGVVKFELNIITKNFQRYGILC
Protein: GTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3) (Q96F15)
Organism: Homo sapiens (Human)
Function: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity).
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:21487483, ECO:0000269|PubMed:29382851}; Single-pass type IV membrane protein {ECO:0000305}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:Q8K3L6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8K3L6}. Note=The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. {ECO:0000305|PubMed:14724691, ECO:0000305|PubMed:21487483}.
Interaction partners:
- GTPase IMAP family member 4
- GTPase IMAP family member 7
- GTPase IMAP family member 6
- GTPase IMAP family member 8
- GIMAP1-GIMAP5 readthrough
- Apoptosis regulator Bcl-2
- GTPase IMAP family member 1
Sequence:
MGGFQRGKYGTMAEGRSEDNLSATPPALRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVRECERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQEDYRQYQAKVEWQVEKHKQELRENESNWAYKALLRVKHLMLLHYEIFVFLLLCSILFFIIFLFIFHYI
Protein: Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) (Q5KU26)
Organism: Homo sapiens (Human)
Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Subcellular location: Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
Interaction partners:
- LIM domain kinase 2
- Paired immunoglobulin-like type 2 receptor alpha
- Apolipoprotein B-100
Sequence:
MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSELSTFRSDILDLRQQLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTPAPEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDFQCEDVNNFICEKDRETVLSSAL
Protein: Chemokine interleukin-8-like domain-containing protein (A0A060WRY3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- CXC chemokine d variant 1
- Chemokine interleukin-8-like domain-containing protein
- Stromal cell-derived factor 1
- Chemokine interleukin-8-like domain-containing protein
- Chemokine interleukin-8-like domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- C-X-C chemokine receptor type 2
- G-protein coupled receptors family 1 profile domain-containing protein
- Chemokine
Sequence:
MSIRMSASLVVVLLALLTITEEMSLRGMGADLRCRCIETESRRIGKLIKKVEMFPPSSHCRDTEIIATLSKSGQEICLDVSAPWVKKVIEKMLAK
Protein: Penicillinase repressor (Beta-lactamase repressor protein) (Regulatory protein BlaI) (P0A042)
Organism: Staphylococcus aureus
Function: Transcriptional repressor that constitutively blocks expression of beta-lactamase. Binds DNA as a dimer (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MANKQVEISMAEWDVMNIIWGKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFLNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILNDISKK
Protein: ESX-5 secretion-associated protein EspG5 (O53943)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B2HSU5}.
Interaction partners:
- PPE family protein PPE15
- PPE family protein PPE41
- PE-PGRS family protein PE25
- ESX-5 secretion system protein EccC5
- PE family protein PE8
- PPE family protein PPE43
- PPE family protein PPE44
- ESX-5 secretion system protein EccD5
- Mycosin-5
- ESX-5 secretion system protein EccE5
Sequence:
MDQQSTRTDITVNVDGFWMLQALLDIRHVAPELRCRPYVSTDSNDWLNEHPGMAVMREQGIVVNDAVNEQVAARMKVLAAPDLEVVALLSRGKLLYGVIDDENQPPGSRDIPDNEFRVVLARRGQHWVSAVRVGNDITVDDVTVSDSASIAALVMDGLESIHHADPAAINAVNVPMEEMLEATKSWQESGFNVFSGGDLRRMGISAATVAALGQALSDPAAEVAVYARQYRDDAKGPSASVLSLKDGSGGRIALYQQARTAGSGEAWLAICPATPQLVQVGVKTVLDTLPYGEWKTHSRV