wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome P450 4A10 (CYPIVA10) (Cytochrome P450-LA-omega 1) (Cytochrome P452) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (O88833)
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids (By similarity). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (By similarity). In kidney, may play an important role in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (By similarity). Also participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) in kidney by converting 8,9-epoxyeicosatrienoic acid (EET) to 20,8,9-HEET, an activator of PPARA. Displays substantially lower fatty acid omega-1 hydroxylase activity (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08516}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:P08516}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 4A14
- Cytochrome P450 2E1
- Cytochrome P450 1A2
- Cytochrome P450 1A1
- Cytochrome P450 2U1
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Prostaglandin G/H synthase 2
- Polyunsaturated fatty acid
- Prostaglandin G/H synthase 1
Sequence:
MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEKFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH
Protein: Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) (Q7Z4L5)
Organism: Homo sapiens (Human)
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0HA38}.
Interaction partners:
- WD repeat-containing protein 35
- Intraflagellar transport protein 43 homolog
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 140 homolog
- Tubby-related protein 3
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 74 homolog
Sequence:
MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWHIGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISVLETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGASTKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSWLLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKYSNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP
Protein: LIM zinc-binding domain-containing protein (Q9GP96)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPFKPVEHPKCPKCGKSVYAAEEMSAGGYKWHKFCFKCSMCNKLLDSMSCCEHQAQLFCKQCHCRRYGPKGIGFGIGAGSLTMDTGEQFGNTEVDMTNRPMTAEAFTAPINPSHS
Protein: Piwi-related protein (Q8MXZ9)
Organism: Tetrahymena thermophila
Interaction partners:
Sequence:
MSNKGLVQNNPRLRFLCNYYQVMLHNEKIYSYQFSVEGMEAAEVMKRTGEILKACINKLREVFTNKFLFQHSVLYSPVQLQANQMTEIGTVDTKTVSLKLLGEANNEREVQNIFGRLIKTVFAKIKLNKLGRKYFDPASRKEYNEYDLAVFSGYESSLEKYSFNQKLLNIDSCFKVQRTSNLLQALQQVKDRNDLSGFVGNTVITSYNGKFHRIESIEKDMSPNDAFEDRKGTKKTYMQYYKEAYNIGNIDPNQPLVKCVELKGKTKTPFTYYLIPSLCQVTGLTDQQRNDFNLMKKLAEVTKPKAGERIAQASKFIQRIKQDADKTLKDWSVEICEKPQTIDYKQLDAGNMEMQQGKKKINVATGSLDRDTQTQMFEQPSLNMWAIIYSDRDQKTFDSLLRTFQECLKFYNYPCKPPNCISVQSRGAQDWINALKNAPDNVQMAVFLLPGKKKAGMYYDEIKRYFTNVKPIPTQVILASTAMKDKGLRSVVNKLLMQICAKTGGVPWVMDNLPFQNLPTMVVGMDVFHNTPGKKESIFGFVSTVDRNFSKYYSHSHVLPTGQEITPFLQQVYEQALKEFKDSNGVYPQQIIIFRDGVGEGQFNAVKDIEMPQLKQACQKINGCENIKFTLIIVNKKVGAKFYQSQDGNVGSAENPPQGALIEDRVTKGVNDFFIVSQKTNQGTASPTHYTIIYNDMIDEALQKDNSPQYREFKRDLQVLAFKLCFLYYNWTGAIKTPSAVRYAHTLSNFVGDRYNPRKNDDTLIQAHPKYDKFRSLYFI
Protein: Complement factor D (EC 3.4.21.46) (28 kDa adipocyte protein) (Adipsin) (C3 convertase activator) (Properdin factor D) (P03953)
Organism: Mus musculus (Mouse)
Function: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Subcellular location: Secreted.
Interaction partners:
- Complement factor B
- Adiponectin
- Complement C3
- Properdin
- Resistin
- Complement C4-B
- Ficolin-2
- Ficolin-1
- Leptin
- Fatty acid-binding protein, adipocyte
Sequence:
MHSSVYFVALVILGAAVCAAQPRGRILGGQEAAAHARPYMASVQVNGTHVCGGTLLDEQWVLSAAHCMDGVTDDDSVQVLLGAHSLSAPEPYKRWYDVQSVVPHPGSRPDSLEDDLILFKLSQNASLGPHVRPLPLQYEDKEVEPGTLCDVAGWGVVTHAGRRPDVLHQLRVSIMNRTTCNLRTYHDGVVTINMMCAESNRRDTCRGDSGSPLVCGDAVEGVVTWGSRVCGNGKKPGVYTRVSSYRMWIENITNGNMTS
Protein: General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) (Q6EKJ0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor II-I repeat domain-containing protein 2A
- Neutrophil cytosol factor 1
- General transcription factor II-I
Sequence:
MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYTERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFLRVEKSLKKFCINWSRLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLVSRNESDGLNYIPKIAELKTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT
Protein: Sin3A, isoform I (A0A0B4LF93)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00810}.
Interaction partners:
Sequence:
MMKRTRVDEVQFGTRPVPQTSGGVGVGVVGVTGGGPTSGGGGTATVGVNTTGVTIGTVVPSAHNATISGIGSIHHRILTPQHGGAQTIAYLPSTTPTATNLKTTTSIVDSTTAGGPVGAGAQVAVGVGSAAGGGGVVVSTGSTGTQTLQYTTSYSVASIQAGGTLKANTADGANTVQIHVTGGGAANNPASAQTVSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAEA
Protein: Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86) (Q6NVF0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling.
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:D3ZGS3}. Early endosome membrane {ECO:0000250|UniProtKB:Q01968}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q01968}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q01968}. Cell projection, cilium {ECO:0000250|UniProtKB:Q01968}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:D3ZGS3}. Endosome {ECO:0000250|UniProtKB:Q01968}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:D3ZGS3}. Note=Also found on macropinosomes. {ECO:0000250|UniProtKB:Q01968}.
Interaction partners:
- Phosphatidylinositol-3-phosphatase SAC1
- Ras-related protein Rab-8A
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Inositol polyphosphate-4-phosphatase type I A
- Ras-related protein Rab-35
- DCC-interacting protein 13-alpha
- Type II inositol 3,4-bisphosphate 4-phosphatase
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Synaptojanin-1
Sequence:
MEPRLPIGAQPLAMVAGLEMKGPLREPCVLTLARRNGQYELIIQLHGKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWTRERHFEIPDEERCLKFLSEVLEAQEAQSQLLVPEQKDSSSWYQKLDTMDKPAYSGLLGFEDNFSSLDLDKKMNTQNPRSGSHREPPPPPSSSTRMLSREKEASNKEQPKVTNTMRKLFVPNTQTGQREGLIKHILTKREKEYVNIQSFRFFVGTWNVNGQSPDSSLEPWLDCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSLAVERGLPSKAKYRKVQLVRLVGMMLLIFARKDQCQYIRDVATETTGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEEFERRNQDYKDICARMTFSVPNQTVPQVNIMKHDVVIWLGDLNYRLCMPDASEVKSLINKNELHKLLKFDQLNIQRTQKKAFADFNEGEINFVPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGINVNQLHYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVRIMDRMENDFLPSLELSRREFFFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYLEPNETLDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTIGGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEEDSYLEKEKSLLQMVPLDEGTSERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGNNHSVAEALLIFLEALPEPVICYELYQRCLDSAHDPRICKQVISQLPRCHRNVFRYLMAFLRELLKFSDYNNINTNMIATLFSSLLLRPPPNLMTRQTPNDRQHAIQFLLVFLLGNEED
Protein: HIG1 domain-containing protein (O01257)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- Cytochrome c oxidase subunit 6A, mitochondrial
- COX5B-domain-containing protein
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome oxidase c subunit VIb
- Ragulator complex protein LAMTOR2 homolog
Sequence:
MNAEPHDFRDHKAHIKWTQEREAYRASIPLIPQDMSGGSRGQTASTTALQKALNNPLVPLGMLATTGCLIGMMVATLRRSSRGAQYFMRGRVVAQGFTVAALVGGAVMFGIGAPTEAALRAPGKGQANIVSLTPPPAVPQNNSA
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (G5EB34)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
- Pentafunctional AROM polypeptide
- Phospho-2-dehydro-3-deoxyheptonate aldolase
- Phospho-2-dehydro-3-deoxyheptonate aldolase
- Uncharacterized protein
Sequence:
MSGQNEDTRVLGYDPLLSPEFVQSEIPSNEHSIPTVRSGRNQAVEIIEQRDDRLLVVVGPCSIHDPETALEYATRLKELAARLSSDLCVIMRAYLEKPRTTVGWKGLINDPDIDESYQINKGLRVSRKLYADLTGMGMPIASEMLDTISPQYMADLISLGAIGARTTESQLHRELASGLSFPIGYKNGTDGNLTVAIDAIGAAAHPHRFLGVTKQGLAAITKTAGNPHGFVIMRGGNKGTNYDRESIQGAREALRGKKQREVLMVDCSHGNSKKNHRNQPLVAKEVADQLREGQDAIIGVMIESNINEGNQKVPPEGPSGLKKGVSITDACIDWETTVTVLEDLADAVRARRAVKSKANGTA
Protein: Glycine-rich selenoprotein (G-rich selenoprotein) (dSelG) (Q7Z2C4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in the life span. May be involved in regulating the redox state of the cell and possesses anticarcinogenic properties.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16920070}; Single-pass type III membrane protein {ECO:0000269|PubMed:16920070}.
Interaction partners:
- Selenoprotein BthD
- Selenide, water dikinase 2
Sequence:
MVYIDHNGRVWEKRPWDWRRIVELFVGIWFAIKQLFLTFLAPFTGNNNQANPRRGNGWGGGGGWGGGGGGGGGGGGGRPGSGSGGLRPNRRIGRIQPTMSCNMPAGGGUG
Protein: Putative pumillio protein 5 (Q4QJ74)
Organism: Leishmania major
Interaction partners:
- Putative pumillio protein 4
Sequence:
MVLKSNYPDAQPPTAMGAPPKKGPQPYRSPCYSSASANPTAASTLVQPFSLPMALQSPRMLPSHGPRPTVLIPISGHETIESSKQSGKMYTHNPYASTCTTPSACLAQSTSMESSSFTSPYVTAMVPRTTAMTPPHFSCASTFPVYAASEGSCCEAGALANMLEDQFLSVLGNIPSTAMSSRGRHVLLNVLRLQHMDKIQMIYDELVPQFNIIAMDQHGCHVARTLIEYISTPQMEALVPYIDLHVIRQMATTTQHTRRVLQAIFEHHKSDALMPIVEVVTSDCQRLSVTQQGCIAIIRIIEYAKPAQKRTLISALVPLLSTLAKNQFGNYVVQCILKNMEGYVSLNDLVGSFQGHWVELSCDKYSSNVMEKIVGMLQGSLRQRIVNELIFDVAHLQCLMQNSFGNYVLQAVIGSAVNQYEYGLIYDAVTPLLHTSPYGHRIEAKLKSRCDALYSKAAPAGTTPVDAMNK
Protein: Nuclear receptor subfamily 3 group C member 1 (Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)) (Q3MSN4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSAST
Protein: Actin-related protein 5 (Q940Z2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable subunit of a chromatin-remodeling complex. Involved in DNA repair. Required for multicellular development of all organs.
Subcellular location: Nucleus {ECO:0000269|PubMed:10907853}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19679120}. Cytoplasm {ECO:0000269|PubMed:19679120}. Note=Localized in the nucleoplasm of interphase cells (PubMed:19679120). However, dispersed into the cytoplasm in dividing cells at metaphase (PubMed:19679120).
Interaction partners:
- DNA-binding protein-like
- RuvB-like protein 1
- Protein EIN6 ENHANCER
- Actin-related protein 9
- Actin-related protein 4
- Chromatin-remodeling ATPase INO80
- palmitoyl-protein hydrolase
- RuvB-like helicase
- RuvB-like helicase
- Actin-related protein 8
Sequence:
MAFVSRIRRQSDYNTYPSSIPIVIDNGASYFRIGWAGETEPRVVFRNIVQRPRHKATGETVTIVGDLDPSMMKYFDCTRSGPRSPFDSNVVYQFEIMEYILDYAFDRLGANGSGIDHPILITECACNPVQSRSKMAELLFETYGVPAVAFGVDAAFSYKYNQLHGICKKDGIVLCPGFTTTHSIPFVDGEPIYKGSSRTNIGGYHVTDYLKQLLSLKYPFHSSRFTWEKAEDLKLEHCYIAPDYASEIRLFQEGRKEAEEKTSYWQLPWIPPPTEVPPSEEEIARKAAIREKQGQRLREMAEAKRVSKINDMENQLISLRFLLKQVDQVEEDDIPTFLSDTGYASRQELESTITKVTQSLRKARGEPKNEPAEYEENPDSLNNEKYPLMNVPDDILTPEQLKDKKRQMFLKTTAEGRLRARQKRNEEELEKEKRNQLEEERRRENPESYLEELQAQYKEVLERVEQKKRLKTNGSSNGNNKSGGIGRGERLSAAQRERMRLLTTAAFDRGKGEDTFGSRDEDWQLYKLMSKDNDDDDEQPDSDEAELARLSSRLQEIDPTFVQKVEGELSQTSGEVPRVRPLTEEDYKIVIGIERFRCPEILFHPNLIGIDQVGLDEMAGTSIRRLPHDEKELEERLTSSILMTGGCSLLPGMNERLECGIRMIRPCGSPINVVRAMDPVLDAWRGASAFAANLNFLGNAFTKMDYDEKGEDWLRNYQIRYNYL
Protein: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (Q9U221)
Organism: Caenorhabditis elegans
Function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03166}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03166, ECO:0000269|PubMed:20493785}.
Interaction partners:
- Apurinic-apyrimidinic endonuclease
- exodeoxyribonuclease III
- dUTP diphosphatase
- Endonuclease III homolog
- DDB1- and CUL4-associated factor homolog 1
- DNA damage-binding protein 1
- DNA mismatch repair protein
- Flap endonuclease 1
- DNA repair protein REV1
- Proliferating cell nuclear antigen
Sequence:
MSKTVRIPDMFLKASAASKRKSASNTENIPEKVPAGNENQEVKKMKLQAPEPTEILLKSLLTGESWSKLLEEEFKKGYISKIEKFLNSEVNKGKQVFPPPTQIFTTFNLLPFDEISVVIIGQDPYHDDNQAHGLSFSVQKGVKPPPSLKNIYKELESDIEGFKRPDHGNLLGWTRQGVFMLNATLTVRAHEANSHAKIGWQTFTDTVIRIISRQSEKPIVFLLWGGFAHKKEELIDTKKHVVIKTAHPSPLSARKWWGCKCFSKCNTELENSGRNPINWADL
Protein: Transcriptional regulator of virulence RegA (D2TIS0)
Organism: Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)
Interaction partners:
- Adhesin autotransporter
- Membrane protein
- Large repetitive protein
Sequence:
MNRQSALSNLSIPAKNSLAHNNMLVLKKIRFYNCAIIHLRDAQLLIRTKDGQTLNIPPESLCYVEKNTVMDVALKVLGSGVPYEVYHVDSDVLRCICKVMEPLLLDPQRVNHTRRKIFTCAVDETDTRIFKRLTGSNVPQHRLVYKITYLLSKVNDIESLVYSLSVSTDTTFTEKLKVIIEADLSRSWRLVDLANILHMSEVSIRKKLEKESNNFNALVLDIRMYHAAKLITTSDKHINSIANEVGYTSTSYFIRNFKEFFGITPKQFSLKVKKQP
Protein: Protein PALS1 (MAGUK family factor) (MAGUK p55 subfamily member 5-A) (Nagie oko protein) (Protein associated with Lin-7 1) (Q8JHF4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:11992120}; Peripheral membrane protein {ECO:0000269|PubMed:11992120}. Cell junction, tight junction {ECO:0000269|PubMed:11992120}. Note=Localizes to the apical region of the cell membrane, in the vicinity of junctional complexes in the neuroepithelium and the photoreceptor layer. Enriched in the areas immediately apical to the adherens junctions-associated actin bundles.
Interaction partners:
- PATJ crumbs cell polarity complex component.
- Crb2
- Crumbs homolog 3a
- Protein kinase C iota type
- Si:dkey-92j12.5.
- Crumbs cell polarity complex component 2b.
- Par-6 family cell polarity regulator alpha.
- Crumbs-like protein 3b.
- Par-6 family cell polarity regulator gamma b
- Protein lin-7 homolog
Sequence:
MTTSHMNGYVTESDGGGGTDIVEEGVQRHREMAVDCPSELGARTLPVRRSAQLEKIRQQQEDRRRREEEGRSRQELDLNSSMRLKKLSQNPKVGIDNPTFEQMEGPGGSAGGLQSLIAPPALLELEDLLMSLKQVQHSLNDSQSQEDVELVLQLVQKPDFQKAFSIHNSVAHYMNRPSPPYPLTDHAQTLAQEVEVMVQNSSHKEGLELSSLLSTSHMQALMMAHDSVAEQEMQLEPLVPSVNASETLTQWGGETVKIVRIEKAKDIPLGATVRNDMDSVVISRIVKGGAAERSGLLHEGDEILEINGVEIRGKDVNEVFDILADMHGVLSFVLIPSAQIKSPPIKETVVHVKAHFDYDPSDDPYVPCRELGLCFQKGDILHIISQDDPNWWQAYRDGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKTGKLWCAKKTKKKRKKMQYNANKNDDFDNEEILTYEEMALYHQPANRKRPIALIGPPNCGQNELRQRLLSTEPDRFAGPVPHTTRSRRDAEANGRDYHFVSRQAFEMDSAAGKFIESGEFEKNFYGTSTDSVRQVINTGKICLLCVHTQSLKVLRSSDLKPYIIFIAPPSQERLRALLAKDNKNPKPEELRDIIEKAREMEQNYGHLFDAAIVNTDLDKSYQELLRLINKLDTEPQWVPSSWLR
Protein: Signal transducing adaptor molecule (A6NMU3)
Organism: Homo sapiens (Human)
Subcellular location: Early endosome membrane {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004469}.
Interaction partners:
Sequence:
MVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQF
Protein: COBRA-like protein 4 (Q9LFW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Cellulose synthase A catalytic subunit 4
- Cellulose synthase A catalytic subunit 8
- Cellulose synthase A catalytic subunit 7
- Chitinase-like protein 2
- Probable galacturonosyltransferase 12
- Beta-1,4-xylosyltransferase IRX9
- Fasciclin-like arabinogalactan protein 11
- Laccase-4
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 1
- Protein IRREGULAR XYLEM 15
Sequence:
MRLLFSFCFFFFMIIFTATAYDPLDPSGNITIKWDIMSWTADGYVATVTMNNFQIYRHIQNPGWTLGWTWAKKEVIWSMVGAQTTEQGDCSKFKGNVPHCCKKTPTVVDLLPGVPYNQQFSNCCKGGVIGAWGQDPSAAVSQFQVSAGLAGTTNKTVKLPKNFTLLGPGPGYTCGPAKIVPSTVFLTTDKRRKTQALMTWNVTCTYSQFLARKHPSCCVSFSSFYNDTITPCPSCACGCENKKSCVKADSKILTKKGLNTPKKDNTPLLQCTHHMCPVRVHWHVKTNYKDYWRVKIAITNFNYRMNHTLWTLAIQHPNLNNVTQVFSFDYKPVSPYGSINDTGMFYGTKFYNDLLMEAGPSGNVQSEVLLQKDQKTFTFKQGWAFPRKVYFNGDECMLPPPDSYPFLPNSAQGNFASFSLTILLLLFISIW
Protein: Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Q812A3)
Organism: Mus musculus (Mouse)
Function: May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.
Subcellular location: Nucleus. Note=Sarcomeric I-band and some intercalated disks. {ECO:0000250}.
Interaction partners:
- Titin
- Myopalladin
- Calpain-3
- Protein phosphatase 1 regulatory subunit 27
- Myosin-binding protein C, fast-type
Sequence:
MDFISIEQLVSGERVDRKALEFGRGVPDPGGWPSGWTLGPQEAVAREKLKLEEEKRKKLERFNSSRLTLDNLTDLENLVQRRRKKRQRHKVPPREPESGAEPQPQVPLEPVGLEMFLKAAAENQEALIDKYLADGGDPNAHDKLHRTALHWACLKGHRQLVNKLLAAGAAIEVRDLLDRTPVFWACRGGHLDILKRLLNQGAQVNAQDKIWSTPLHVAVRMGHSDCLEHLIECGAHINAQDKEGDTALHEAVRYGHHKATKLLLLYGAKLGVKNVASQTPVQLARDWQRGIRDALQAHVGHPRTRC