wanglab/gogpt-training-data huggingface dataset:
Protein: MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (Kidney cell line-derived transcript 1) (Q8BX65)
Organism: Mus musculus (Mouse)
Function: Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation. Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin-regulation of the WNT and JNK signaling pathways. Involved in the development of lymphatic vessel valves. It is required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9P1T7}. Cell membrane {ECO:0000305|PubMed:35235341}; Single-pass membrane protein {ECO:0000305|PubMed:35235341}. Secreted {ECO:0000269|PubMed:35235341}.
Interaction partners:
Sequence:
MSCAGEALAPGPAEQQCPVEAGGGRLGSPAHEACNEDNTEKDKRPATSGHTRCGLMRDQSIWPNPSAGELVRTQPERLPQLQTSAQEPGKEETGKIKNGGHTRMSNGNGIPHGAKHVSVENHKISAPVSQKMHRKIQSSLSVNNDISKKSKVNAVFSPKAASSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCSCPCDMDCGIMDACCESSDCLEICMECCGICFPS
Protein: Large ribosomal subunit protein uL13 (60S ribosomal protein L13a) (A0A1W2Q6L2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS7
- Ubiquitin-ribosomal protein eL40 fusion protein
- Large ribosomal subunit protein bL17m
- Mitochondrial ribosomal protein S9
Sequence:
MSPKSALLSLPRPCHRHEGSPAEMTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISSNFHMRISELTDYLLKDYPVTVAINLQDEKHCKALWSLFLAHRWIEQLKTVAGSKMQKLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHLLQDTCSQLLALKPCIGKACQNFSRCLEVQCQPDSSTLLPPESPGALGATELPKPQPRQLWLLLLLPLTVVLLAAAWCLRWQRTRRRVELRPGVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVLDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLLRLRKQAEKNVEKKICKFTEVLKTNGLLV
Protein: Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase) (Q383M7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine/threonine-protein kinase, putative
- Structural maintenance of chromosomes protein
- separase
- Structural maintenance of chromosomes protein
- Ubiquitin-protein ligase, putative
- Tyrosine phosphatase, putative
- Rev7, putative
- Uncharacterized protein
- Uncharacterized protein
- Cell division cycle protein, putative
Sequence:
MFNVSPASRDRVRSESQRTPRPRSSLSMPRELSYTPAISSIPSSLHTPFIQKCYVQGDNSTEGQQQQQQQPPDHMTVVFESDNMQLTTTSLLGKGGFGRVYVAQSSGGELCALKVSSKQMTDGDWERLRKEVALMSHFSQHPNVVKLIAAGRDRNFAYVAMECCASRSLHDIINKHGLEVPEILWVGYALIDTIAFLHAKGCIHRDLKPQNLLFDFDGNLKISDFGLSSNVTESEPRKTVAGTAMYMAPEIAGAVYKRMTNDNSSSSLRYGQEVDTWSIGVVLYVMLTRMNPYAQALENEGAHEMNKTQKTLTLFSAVAGAAWHWPAGWRGDKELSDVVNQILHRNPAQRATLQDILQHPVWDRRPLSCPLTLLQKLNLVERRPFTRTGAVGRSCSRAPEGMQPQYATKTAEVVLLEGLNQVIQVEESTRTQLVLESNEVINLIFGTLKLHASEANGRRFIVIDEKGCRKNIEDMLLTTRPVRCRSHELVSTAVCAKQPKRGTRVGSSLRPQRESSVLLAGPLAFGQTQDAGEIVRAASDRYAVVFSGRETSTRWSLRNVISLPRELNAAIEEVTCINKHQMKKLIKIPLGYVGFDCNVCDSAIDDISIEKPVFRCHKCDYDLCMNCAYEGKIKDVNFVCVSCMKKFASSSKLEAHSAKCRGPSMSPSARCSSRRNTMLWEQLENEGGSLLDIRLPTETKPRRSARTSCRTSGGRESSGGRISIGDSYVPGPEDLGTMVVAHRDANFPEMPKFSTQSDSKASSPFGEKEGADKNYRQSFSFELPPQVRLSKHRRDKGAEPRSSEELREIVDELTPTPKRVRTEARQNSCEPYAPQVNDAGLVVGIAARSRVEREGSLRGEQQSRNVVVIRADNAAKPQDLRKQSQVPRSASSSQPGSRMESQAIDTLSKPAPKNVAVREYRSASGQRDPLVPRTSLPSAQTGEIFGAPPLPRIVTSGRSSVPRSMSYTLPSAAGVARRQTSQPLVNLLGGVPVGAYGGGSFNPGERNASISNTNRTVGPGQGGTAYLALPRDKQNRDRFVDDFLSGAWVRVYSFIGSEVVVMYYSVQPGRYGALFPTEEGAATAVLDIHSKLVLYVPRMDKDTVTRTQCHPNVLSFFQDEIRILPATSAEKTLGGVLRGIMGFVSELTKCRGEGEKYAAAQSAYIHQREKGAVPAGTKFAYVRKAFPDPAGSFVLFRLSNLRSQVVFNNALLDIRWQSDKNHNVGQKYYVRPNGEAGPFTAEHSGILNHVNLVMRNVYRK
Protein: Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) (Q9H4A6)
Organism: Homo sapiens (Human)
Function: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.
Subcellular location: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
Interaction partners:
- Unconventional myosin-XVIIIa
- Protein transport protein Sec24B
- ADP-ribosylation factor 1
- Coatomer subunit beta
- Serine/threonine-protein phosphatase with EF-hands 1
- T-cell surface glycoprotein CD4
- Golgin subfamily A member 2
- Proprotein convertase subtilisin/kexin type 9
- Coatomer subunit delta
- Protein SEC13 homolog
Sequence:
MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGRLQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGETWNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQEAVLDKWVNDPHRMDRRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDPEVECLKANTNEVLWAVVAAFTK
Protein: Elf1p (A0A1D8PTY4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Rpl7p
- rRNA-processing protein
- Elongation factor 3
- Utp4p
- Cam1-1p
- Translation elongation factor EF1B gamma
- Large ribosomal subunit protein eL27
- Tef4p
- H/ACA ribonucleoprotein complex subunit 2
- Large ribosomal subunit protein uL18
Sequence:
MSKSFDDFIKQQKQQQSKPKGFGYRNNNQGGYNYNQAYGNVPTFQPGNQQFQYQGGYNQGFNQQQYQYQGQGYNNQGYNSNNRYNNSNNYNYNNNTNQSSTISTPVDSLPTSGRSTPNPNASTTSLTSLNTALAKLNVSNIPFEENLSNIEKAGKIAEIRPEVETIVKIIDEQEDLSIINEWKLNEILKSLLKPKSPALVKEGALLIIQQLATKFGGQTPKEAYLLQFLSTAYDMFTDKDKNVVKAAKSATDALFGIYPVEALGSIVLDEYLTIFKSGAKWNSKVAALVNFDKLIDDVPADILEMKFIDVVPVLTDLSTDFKPELAKAGLSTLKKFVKVLDNLDLQNKYDLIVDTLADPKKVTDCIKNLSSVTFVAEVTEPALSLLVPILDKSLKMSSSSNEQLRQTVMVTENLTRLVNNKREIEQFIPILLPGVEKVVNNASLPEVRELAGKALKVLKDAENEQTDGKFHGRITLEQAEKFYTEDIPDEQHQQPVQLLKDDILKKYLATVLQIDAHVNDWKRLQEYLMMATNNNETYSQLVVTHVKNLFNPESAADNENDDGAVVIVDADFSLAYGTRMLLNKTKLRLLKGHRYGLCGRNGAGKSTLMRAISKGQLEGFPTADELKTCFVEHKLQGSEADMDLVSFIGSDPELANVGREEIEQALKDVGFPDERLQQQVGSLSGGWKMKLELARAMLMKADVLLLDEPTNHLDVANVKWLQDYLVENTEITSLIVSHDSGFLDAVCTDIIHYENKKLAYYKGNLSEFVKIKPEGKSYYTLTDSNVKMAFPPPGILTGVKSNTRAVARMSNVTFAYPGADKPSLKNVSCSLSLSSRVAILGPNGAGKSTLIKLLTAELVPQEGKVEKHPNLRIGYIAQHALQHVEQHKEKTANQYLQWRYRFGDDREVLLKESRKVSDEEQEMMKKEIDIGDGRGKRAIEALVGRQKLKKSFQYEVKWKYWLPKYNSWVPKEVLLEHGFDKLIQKFDDHEASREGLGYRELTPSVIRKHFEDVGLDGDIADHTPMGSLSGGQLVKVVIAGAMWNNPHLLVLDEPTNYLDRDSLGGLAMAIREWNGGVVMISHNNEFVGALCPEQWHVENGEVIQKGTVAVDAKRFEDQGGDEASSSKEGTPVPEPVKKRADDDDSPANIKVRTRKKKMTRNEKKAQAERRRLRYIEWLSSPKGTPKPVDTDDEED
Protein: Protein tweety homolog 1 (hTTY1) (Volume-regulated anion channel subunit TTYH1) (Q9H313)
Organism: Homo sapiens (Human)
Function: Probable chloride channel. May be involved in cell adhesion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:34385445}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
Protein: Small ribosomal subunit protein uS12A (40S ribosomal protein S23-A) (P0CT75)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P0CX29}. Nucleus {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein eS8A
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL28
- Elongation factor 3
Sequence:
MGKPAGLNAARKLRNHRREERWADAHYKKRLLGTAYKSSPFGGSSHAKGIVVEKIGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPHDGCLNFVDENDEVLLSGFGRKGKAKGDIPGVRFKVVKVAGVGLSALFHEKKEKPRA
Protein: Transcription factor bHLH75 (Basic helix-loop-helix protein 75) (AtbHLH75) (bHLH 75) (Transcription factor EN 78) (bHLH transcription factor bHLH075) (A4D998)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- At1g25320/F4F7_17
- TPR repeat-containing thioredoxin TTL4
Sequence:
MARFEPYNYNNGHDPFFAHINQNPELINLDLPASTPSSFMLFSNGALVDANHNNSHFFPNLLHGNTRRKGNKEESGSKRRRKRSEEEEAMNGDETQKPKDVVHVRAKRGQATDSHSLAERVRREKINERLKCLQDLVPGCYKAMGMAVMLDVIIDYVRSLQNQIEFLSMKLSAASACYDLNSLDIEPTDIFQGGNIHSAAEMERILRESVGTQPPNFSSTLPF
Protein: galactinol--sucrose galactosyltransferase (EC 2.4.1.82) (F4K470)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASQSCYNGIHRIKRVHPLIHSLTFHRFSSSSLPFKSHIPSSQQQLRIRSSSSLSDLGNRRHCSSTRGFQFWSYKRSEAASPFKTRYRENEEEEDMTIKPAVRISDGNLIIKNRTILTGVPDNVITTSASEAGPVEGVFVGAVFNKEESKHIVPIGTLRNSRFMSCFRFKLWWMAQRMGEMGRDIPYETQFLLVESNDGSHLESDGANGVECNQKVYTVFLPLIEGSFRSCLQGNVNDEVELCLESGDVDTKRSSFTHSLYIHAGTDPFQTITDAIRTVKLHLNSFRQRHEKKLPGIVDYFGWCTWDAFYQEVTQEGVEAGLKSLAAGGTPPKFVIIDDGWQSVERDATVEAGDEKKESPIFRLTGIKENEKFKKKDDPNVGIKNIVKIAKEKHGLKYVYVWHAITGYWGGVRPGEEYGSVMKYPNMSKGVVENDPTWKTDVMTLQGLGLVSPKKVYKFYNELHSYLADAGVDGVKVDVQCVLETLGGGLGGRVELTRQFHQALDSSVAKNFPDNGCIACMSHNTDALYCSKQAAVIRASDDFYPRDPVSHTIHIASVAYNSVFLGEFMQPDWDMFHSVHPAAEYHASARAISGGPLYVSDSPGKHNFELLRKLVLPDGSILRARLPGRPTRDCLFADPARDGVSLLKIWNMNKYTGVLGVYNCQGAAWSSTERKNIFHQTKTDSLTGSIRGRDVHSISEASTDPTTWNGDCAVYSQSRGELIVMPYNVSLPVSLKIREHEIFTVSPISHLVDGVSFAPIGLVNMYNSGGAIEGLRYEAEKMKVVMEVKGCGKFGSYSSVKPKRCVVESNEIAFEYDSSSGLVTFELDKMPIENKRFHLIQVEL
Protein: Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (Ubiquitin-like protein SMT3A) (Smt3A) (Q9Z172)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000269|PubMed:18644859}.
Interaction partners:
- SUMO-conjugating enzyme UBC9
- E3 ubiquitin-protein ligase RNF4
- E3 SUMO-protein ligase RanBP2
- E3 SUMO-protein ligase PIAS4
- SUMO-activating enzyme subunit 1
- Ran GTPase-activating protein 1
- Cellular tumor antigen p53
- E3 SUMO-protein ligase PIAS1
- Small ubiquitin-related modifier 1
- SUMO-activating enzyme subunit 2
Sequence:
MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSASRGSVPTPNRCPDLCY
Protein: Transporter (Q9VSV2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKDLKTEILVSGGLPKLETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMDYQMFLRNKDEENSKNVNRRCVCYTAGDRIFG
Protein: Photosystem II reaction center protein K (PSII-K) (P15819)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00441, ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:1904061, ECO:0000269|PubMed:34937700}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00441, ECO:0000269|PubMed:34937700}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II D2 protein
- Cytochrome b559 subunit beta
- Photosystem II extrinsic protein O
- Photosystem II reaction center protein J
- Photosystem II protein D1 2
- Photosystem II reaction center protein X
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein L
- Photosystem II extrinsic protein U
Sequence:
METIYLLAKLPEAYQIFDPLVDVLPVIPLFFLALAFVWQAAVGFK
Protein: Uncharacterized protein YdaE (P38394)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Protein RacC
- Uncharacterized protein YdhS
- Killing protein KilR
- Double-strand break reduction protein
- Uncharacterized protein YdaF
- Carnitine monooxygenase reductase subunit
Sequence:
MTKKIKCAYHLCKKDVEESKAIERMLHFMHGILSKDEPRKYCSEACAEKDQMAHEL
Protein: Dcpp1 protein (Sublingual parotid tongue-1 salivary protein) (Q64097)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFQLEAMLPLLILAFLGTPTVLTQDYHGPEVGKHSCTSAPEGKNITSIRVFLQGRSIVGIQFNYNNEDGQVYGSTAGKVMVARLNNEESIIAAEGTYSPSALTQIIFTTNQPRQLMVGYYVGSSEYSSFPDDPSHVLKGACVSWRAGGIKSILFLWGTENSSCVKYGHSG
Protein: GH12163p (Q95T91)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPGCHMKIYNDEHKIADDVKIGDPLTIVISIDKQKVYGLHVTDCIVRDGLGWGEQRLVGEDGCPMDNEIMGQFNYTQDRLAANVTFPAHKFPYTTSVYYQCNVRLCALEDPTCQEAPQCSGKRPKRQAAADSKEEDGLPATIEVFSGLYVNENENANDSGEDAVYKEKTLDDALCVSQRTFAIAIAIAGLILMLAVVAAVLCIMARRSTKTVSNSGSSIYSGPYTNTAFSHSS
Protein: V-type proton ATPase subunit D (V-type proton ATPase subunit d) (Vacuolar proton pump subunit D) (A0A8I5ZXM1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029434}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029434}.
Interaction partners:
Sequence:
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHGESELLGAALFISLSLPAR
Protein: Receptor-type tyrosine-protein phosphatase V (R-PTP-V) (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase) (P70289)
Organism: Mus musculus (Mouse)
Function: May play a role in the maintenance of pluripotency. Down-regulated during differentiation.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MRPLILLAALLWLQDSLAQEDVCSSLDGSPDRQGGGPPLSVSVTSRGRPTSLFLSWVAAEPGGFDYALCLRAMNLSGFPEGQQLQAHTNESSFEFHGLVPGSRYQLELTVLRPCWQNVTITLTARTAPTVVRGLQLHSTGSPASLEASWSDASGDQDSYQLLLYHPESHTLACNVSVSPDTLSYNFGDLLPGSQYVLEVITWAGSLHAKTSILQWTEPVPPDHLRVRALGTSSLQAFWNSSEGATWFHLILTDLLEGTNLTKVVRQGISTHTFLRLSPGTPYQLKICAAAGPHQIWGPNATEWTYPSYPSDLVLTPLWNELWASWKAGQGARDGYVLKLSGPVENTTTLGPEECNAVFPGPLPPGHYTLGLRVLAGPYDAWVEGSIWLAESAARPMEVPGARLWLEGLEATKQPGRRALLYSVDAPGLLGNISVSSGATHVTFCGLVPGAHYRVDIASSMGDITQSLTGYTSPLPPQSLEIISRNSPSDLTIGWAPAPGQMEGYKVTWHQDGSQRSPGDLVDLGPDISSLTLKSLVPGSCYTVSAWAWSGNLSSDSQKIHSCTRPAPPTNLSLGFAHQPATLRASWCHPPGGRDAFQLRLYRLRPLTLESEKILSQEAQNFSWAQLPAGYEFQVQLSTLWGSEESGSANTTGWTPPSAPTLVNVTSEAPTQLHVSWVHAAGDRSSYQVTLYQESTRTATSIVGPKADSTSFWGLTPGTKYKVEAISWAGPLYTAAANVSAWTYPLTPNELLASMQAGSAVVNLAWPSGPLGRGTCHAQLSDAGHLSWEQPLSLGQDLLMLRNLIPGHTVSLSVKCRAGPLQASTHPLVLSVEPGPVEDVFCQPEATYLSLNWTMPTGDVAVCLVEVEQLVPGGSAHFVFQVNTSEDALLLPNLTPTTSYRLSLTVLGGNRQWSRAVTLVCTTSAEVWHPPELAEAPQVELGTGMGVTVTRGMFGKDDGQIQWYGIIATINMTLAQPSQEAINHTWYDHYYRGHDSYLALLFPNPFYPEPWAVPRSWTVPVGTEDCDNTQEICNGHLKPGFQYRFSIAAFSRLSSPETILAFSAFSEPQASISLVAMPLTVMMGTVVGCIIIVCAVLCLLCRRGLKGPRSEKNGFSQELMPYNLWRTHRPIPSHSFRQSYEAKSARAHQAFFQEFEELKEVGKDQPRLEAEHPANITKNRYPHVLPYDHSRVRLTQLSGEPHSDYINANFIPGYSHPQEIIATQGPLKKTVEDFWRLVWEQQVHVIIMLTVGMENGRVLCEHYWPVNSTPVTHGHITTHLLAEESEDEWTRREFQLQHGAEQKQRRVKQLQFTTWPDHSVPEAPSSLLAFVELVQEEVKATQGKGPILVHCSAGVGRTGTFVALLPAVRQLEEEQVVDVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILEGPSDASDSGPIPVMNFAQACAKRAANANAGFLKEYRLLKQAIKDETGSLLPSPDYNQNSIASCHHSQEQLALVEESPADNMLAASLFPGGPSGRDHVVLTGSAGPKELWEMVWEHGAYVLVSLGLPDTKEKPQDIWPMEMQPIVTDMVTVHRVAESNTAGWPSTLIRVIHGDSGTERQVQCLQFPHCETGSELPANTLLTFLDAVGQCCSRGNSKKPGTLLSHSSKVTNQLSTFLAMEQLLQQAGTERTVDVFSVALKQTQACAVKTPTLEQYIYLYNCLNSALRNRLPRARK
Protein: RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) (Q9CQG2)
Organism: Mus musculus (Mouse)
Function: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (By similarity). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (By similarity). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (By similarity). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (By similarity). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (By similarity). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q86W50}. Cytoplasm {ECO:0000250|UniProtKB:Q86W50}.
Interaction partners:
- RNA-binding protein 15
- Zinc finger CCCH domain-containing protein 13
- Protein virilizer homolog
- Pre-mRNA-splicing regulator WTAP
- N
- N
- rRNA N
- Putative RNA-binding protein 15B
- rRNA N
- E3 ubiquitin-protein ligase Hakai
Sequence:
MALSKSMHARNRYKDKPPDFAYLASKYPDFKQHIQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKTTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIVYDFCMCNPPFFANQLEAKGVNSRNSRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTFTEFCQGRTMRWALAWSFYDDVTVPSPPSKRRKLEKPRKPITFVVLESVMKELSLKASSLGSETAEGIVVVTTWIEKILTDLKVQHKRIPCGREEVSLFLTAIENSWIHLRRKRRERVRQLREVPRAPEDVILALEERKSTPKELSSGQDVAHSPQESALCGLDVPGGEAAADGGHCLSQKLLCQEETPEATEDERDEERGGMEAMESCKGSSNGAQDGEASEKGDRLDGAAGRYLFKCLVNIKKEAGDAVVEMHWVEGQNRDLMNQLCTYVRNQILRLVAS
Protein: Chromosomal replication initiator protein DnaA (O26057)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377, ECO:0000269|PubMed:14643658}. Cell inner membrane {ECO:0000269|PubMed:14643658}. Note=About two-thirds of the protein is found associated with the cell inner membrane (PubMed:14643658). Nucleoid-associated protein is probably in the cell inner membrane fraction (Probable). {ECO:0000269|PubMed:14643658, ECO:0000305}.
Interaction partners:
- DNA replication regulator protein HobA
- Beta sliding clamp
- Replicative DNA helicase DnaB
- Phosphoheptose isomerase
- Ribonuclease P protein component
- DNA gyrase subunit B
- DNA-binding protein HU
- DNA polymerase I
- Probable chromosome-partitioning protein ParB
- tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Sequence:
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITAKYGALLKEILSQNKVGMHLAHSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEYIAQHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSGVKKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE
Protein: Proline utilization trans-activator (P25502)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive activator of the proline utilization pathway. Binds to the promoters of PUT1 and PUT2 genes. Recognizes and binds to the DNA sequence 5'-CGG-N(10)-CCG-3'.
Subcellular location: Nucleus.
Interaction partners:
- Protein LST7
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Proline dehydrogenase, mitochondrial
- Regulatory protein GAL4
- Protein ARG5,6
- Protein SPT10
- Regulatory protein LEU3
- Inositol-3-phosphate synthase
Sequence:
MVTDQGSRHSIQSKQPAYVNKQPQKRQQRSSVACLSCRKRHIKCPGGNPCQKCVTSNAICEYLEPSKKIVVSTKYLQQLQKDLNDKTEENNRLKALLLERPVSVRGKDNSDDDERHINNAPSSDTLEVSSAPAAPIFDLMSNSNTASDNDNDDDNSNRITNNRSYDHSLEKYYKKAISIFKQPANANGENGNGANGHEDDDEDDEEISTNFAQRSGRLIESHNGFHYFVGSSSMTLFGLEIQSLVTKYISVKNFRPLPINTKNKILNSNLNPAISSFINSNNYLFSSYNFLNPISTIVNLNSINDNLSPLMFKIILKSDTDGSSGQEEVIQFQLPSYNYTKLLIDCFINYNDGCFYFFNEGLVKCGINKLYLENKWLYYDNTKKALDNENDPILQAVWFCKILLILAVGEMYLGSINNEMLKNYSNQPKLPGSKFFQMGSKIFNCLFSSERLENVTKKGGIEVLLLYAFFLQVADYTLASYFYFGQALRTCLILGLHVDSQSDTLSRYEIEHHRRLWWTVYMFERMLSSKAGLPLSFTDYTISTALPADIDDETIEEKNSHYVFRKAELISNCVTIVKINAQILSKLYQRQPETNIIITLKVVIKQLLEWRNNLSDSLQVDFTQKDEDFKISRLSTNMFTEYFQGINLAVRPLLFHFASIQLKRFKTSNTFVNLQNYSATISSLLTCSLHASVNTIRSLWSLLQNSMLAMFSYMDREYLFTSSCTLLLFNTAFGIHEQTLYHLDHSLEIFTQMRNLGNIPAGLRRAQLLTLMANLDFHGIMNDLITKYNDILKFDSMNCENDNIVEDSNEPKRETEKCKPHKDGDRIDPSIIDCDKSNTNTNMIKNESISNIVSILPEGAKPTLTDYSNGNNDVNDINVNNSEPSTFFDIITASLENSYQTTLTEKGSQVMEKNMDQLDSVHNLNDDDLQQLLEDLGNIDHSDEKLWKEITDQAMWLGNTMDPTAAAGSEIDFTDYLGP