wanglab/gogpt-training-data huggingface dataset:
Protein: Formin-A (Q54WH2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Interaction partners:
- Rho-related protein racE
Sequence:
MADKLYQIKLDIKKGKNIVGSDGSVCSPYLRVTWGGKKQQKTKVITKSAEPEWNFSCLLEIKKEKNPQKPGLEFELIEHKQFSEKEISSTTYQLPESLILGEACNYSVPMSIATSKGDQKCEILIAITAINFGKDKQDEEKKRHDEIQKKFAQLVEQLATDSKAREGMMKLPYEARAQLVEQHRDKLANEKHPDEYVVLLIKEITRKNIQLAGGLQKSHSASNASLGSLSPVTPRVDDGLSVAELKNISVALRSRGLDWIHQFHKLGATTRLVELLSLYVNKKSHTEESLQKQLECLNCIKNLMNNNVGIGYIFGIKDSFKTIVLCLGSEYEKVNELAIGLLNTICFLPKINGHKLLIELLNYFKEEKKESRRFISIVKSLKSKAGVIETKETLKTKSIYLSFINIIVNTPAEIDLRLALRQEFYWLGIKEILVKLSNYTYDESPELDTQITVFEEEESKDNKEMSERFQEFKGLNLDNVDDVLKTLMDRIRPKGLVDCMREISKDLLLLPIDDDVGIRNWVLASRIIKQISLRDKNIGIDEDILPLENLLLMCEQEAKEVPLKSQIESLKKDAQDLAKKITTQDIELKEKVEIIKKNEELTTKQLEEQINIAKKKDEEINQLKALVEQLKLTQGTAKPDSAAASTSVAPPPPPPPMTGGGAPPPPPPPPPMTGGGGPPPPPPPPPMTGGGPPPPPPPPPMTGGGPPPPPPPPGGGPPPPPPPPGAKAGGPPPPPPPFGKGPPPPPGGFGMKKAAAPPRKEVPVPALKMKGLQWVSLNDKKIQGTIFSKFNLDTSKDINLDYKDIEGVFAAKVIEKKESTAPKKTGPVSIIDPKTSQNLSIFLSQFKGKSYDDICGAISKGDETVFQPNHIDALIGFLPSEDDINNINEFLREEKDITKLGPPEQFSMKIHSVPQVKARLQAMKFKYAYESKKSDLKVDIDNFKQGTQEIKGSEKIPKLLEVILILGNFINGGTARGNAYGFKLNTITKLADTKSTDNKLSLVNYLTRVVIKDFPHLNSFAQDLGHVEAAGRVSLSQVQAEVATLRKEFVQVQKSIETLNSGTGEEAVDPFKVKYEEFCTQTAEDIDLITSSSQQIETDYKDLLAMFGEDSKSEPSEFFGMFTKFMDQYDKATKENEQLSIQAEKIAKREAAKKLKEEEDAKKKQLAEERKQKGETVEVKESVVDDLLDTIASGDAFKNRRRRARKTDQDSTIEPIDL
Protein: RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) (P54132)
Organism: Homo sapiens (Human)
Function: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction. Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:23509288}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
Interaction partners:
- Fanconi anemia group M protein
- Replication protein A 70 kDa DNA-binding subunit
- Fanconi anemia group A protein
- Fanconi anemia group G protein
- RecQ-mediated genome instability protein 1
- DNA topoisomerase 3-alpha
- DNA mismatch repair protein Mlh1
- DNA repair protein RAD51 homolog 1
- Exonuclease 1
- Replication protein A 14 kDa subunit
Sequence:
MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSASHTSQATSGANSKLGIMAPPKPINRPFLKPSYAFS
Protein: Cation channel sperm-associated auxiliary subunit epsilon (CatSper-epsilon) (CatSperepsilon) (Q5SY80)
Organism: Homo sapiens (Human)
Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:28226241}; Single-pass type I membrane protein {ECO:0000255}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000269|PubMed:28226241}.
Interaction partners:
- Cation channel sperm-associated protein 2
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated auxiliary subunit zeta
- Cation channel sperm-associated protein 3
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated auxiliary subunit gamma
- Cation channel sperm-associated protein 4
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated auxiliary subunit TMEM262
Sequence:
MSAREVAVLLLWLSCYGSALWRYSTNSPNYRIFSTRSTIKLEYEGTLFTEWSVPETCFVLNKSSPTTELRCSSPGVHAIKPIVTGPDEEERYLFVESSHTCFLWYYRVRHFFNNFTQLITVWAYDPESADPDELLGNAEEPSINSIVLSTQMATLGQKPVIHTVLKRKVYSSNEKMRRGTWRIVVPMTKDDALKEIRGNQVTFQDCFIADFLILLTFPLLTIPEIPGYLPISSPRGSQLMASWDACVVASAVLVTDMETFHTTDSFKSWTRIRVPPDILSDDERRSVAHVILSRDGIVFLINGVLYIKSFRGFIRLGGIVNLPDGGITGISSRKWCWVNYLLKAKGRRSTFAVWTENEIYLGSILLKFARLVTTTELKNILSLSVTATLTIDRVEYTGHPLEIAVFLNYCTVCNVTKKIFLVIYNEDTKQWVSQDFTLDAPIDSVTMPHFTFSALPGLLLWNKHSIYYCYHNFTFTGILQTPAGHGNLSMLSNDSIIHEVFIDYYGDILVKMENNVIFYSKINTRDAVKLHLWTNYTTRAFIFLSTSGQTYFLYALDDGTIQIQDYPLHLEAQSIAFTTKDKCPYMAFHNNVAHVFYFLDKGEALTVWTQIVYPENTGLYVIVESYGPKILQESHEISFEAAFGYCTKTLTLTFYQNVDYERISDYFETQDKHTGLVLVQFRPSEYSKACPIAQKVFQIAVGCDDKKFIAIKGFSKKGCHHHDFSYVIEKSYLRHQPSKNLRVRYIWGEYGCPLRLDFTEKFQPVVQLFDDNGYVKDVEANFIVWEIHGRDDYSFNNTMAQSGCLHEAQTWKSMIELNKHLPLEEVWGPENYKHCFSYAIGKPGDLNQPYEIINSSNGNHIFWPMGHSGMYVFRVKILDPNYSFCNLTAMFAIETFGLIPSPSVYLVASFLFVLMLLFFTILVLSYFRYMRIYRRYIYEPLHKPQRKRKKN
Protein: Auxin-responsive protein IAA19 (Indoleacetic acid-induced protein 19) (Protein MASSUGU 2) (O24409)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Auxin response factor 5
- Auxin response factor 7
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 8
- Auxin transporter protein 1
- Auxin response factor 1
- Auxin response factor 6
- Protein TOPLESS
- Transcription factor MYB77
- Auxin response factor 19
Sequence:
MEKEGLGLEITELRLGLPGRDVAEKMMKKRAFTEMNMTSSGSNSDQCESGVVSSGGDAEKVNDSPAAKSQVVGWPPVCSYRKKNSCKEASTTKVGLGYVKVSMDGVPYLRKMDLGSSQGYDDLAFALDKLFGFRGIGVALKDGDNCEYVTIYEDKDGDWMLAGDVPWGMFLESCKRLRIMKRSDATGFGLQPRGVDE
Protein: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) (Q01065)
Organism: Mus musculus (Mouse)
Function: Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q01064}.
Interaction partners:
- Calmodulin-1
- Calmodulin-4
- Calmodulin-like protein 3
- Calmodulin 5
- Calmodulin-like protein 4
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
- Adenosine kinase
- Inosine triphosphate pyrophosphatase
Sequence:
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLKNLDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVDVGDPNPDVVSFRATWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD
Protein: Homogentisate phytyltransferase (HPT) (EC 2.5.1.115) (P73726)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Involved in the synthesis of tocopherol (vitamin E). Catalyzes the condensation of homogentisate and phytyl diphosphate to form dimethylphytylhydrquinone.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Slr1737 protein
- Uncharacterized protein slr0090
- Geranylgeranyl diphosphate reductase
- Delta
- 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
- 4-hydroxybenzoate solanesyltransferase
- Prenyl transferase
- dimethylallyltranstransferase
- Sll0659 protein
- Magnesium-protoporphyrin O-methyltransferase
Sequence:
MATIQAFWRFSRPHTIIGTTLSVWAVYLLTILGDGNSVNSPASLDLVFGAWLACLLGNVYIVGLNQLWDVDIDRINKPNLPLANGDFSIAQGRWIVGLCGVASLAIAWGLGLWLGLTVGISLIIGTAYSVPPVRLKRFSLLAALCILTVRGIVVNLGLFLFFRIGLGYPPTLITPIWVLTLFILVFTVAIAIFKDVPDMEGDRQFKIQTLTLQIGKQNVFRGTLILLTGCYLAMAIWGLWAAMPLNTAFLIVSHLCLLALLWWRSRDVHLESKTEIASFYQFIWKLFFLEYLLYPLALWLPNFSNTIF
Protein: U10-myrmicitoxin-Mri1b (U10-MYRTX-Mri1b) (A0A6G9KJV6)
Organism: Manica rubida (European giant red ant)
Function: Induces paralysis after injection into blowflies (L.caesar), and then death within 24 hours. May have antimicrobial properties, like most ant linear peptides (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:32182430}.
Interaction partners:
Sequence:
MRLSYISLTLAIIFVMAIVHAPETEAKAYPEADAVAEAIAVGEADAVGVADPGIKDALAKIWKILKAEVPTVAAAIENKVG
Protein: pyr operon leader peptide (pyrBI operon attenuator) (P0AD83)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Aspartate carbamoyltransferase regulatory chain
- Aspartate carbamoyltransferase catalytic subunit
Sequence:
MVQCVRHFVLPRLKKDAGLPFFFPLITHSQPLNRGAFFCPGVRR
Protein: Metal-dependent protein hydrolase (F4K000)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Similarity to unknown protein
- Zinc ion binding / nucleic acid binding protein
- Rhodanese-like domain-containing protein 14, chloroplastic
- Uncharacterized mitochondrial protein AtMg00860
- Polynucleotidyl transferase, ribonuclease H-like superfamily protein
- Separase
- DNAse I-like superfamily protein
- Acyl-CoA-binding domain-containing protein 1
- Heat shock 70 kDa protein BIP1
- Transcription factor PAR1
Sequence:
MMFSVTKGLIRNLALFQVRLPPLVAAVMAPSSVVRVYSTATSPSPSEISVKKVGTHNGSFHCDEALGCFMIRLVDKFSGADIVRSRDPKILAELDAVLDVGGVYDPEHDRYDHHQKGFEEVFGHGFNTKLSSAGLVYKHFGKEIIAKELNVEQDHPDVLRLFLAVYKSFMEAIDAVDNGINRYDTDQPPRYVNNTHLSPRVGRLNLDWIDPDQSQEKENEAFQRAMALAGKEFLESVQFHARSWLPARSIVMQCLEERFKTDPSGEIMILDRFCPWKLHLFELEQEMKIEPLIKYVIYQDERAKQWRVQAVAVAPDRFENRKPLPEKWRGLRDEELSKAAEIPGCVFVHMSGFIGGNQSYDGALSMAQTALTL
Protein: Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt) (P82929)
Organism: Bos taurus (Bovine)
Function: Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10751423, ECO:0000305}.
Interaction partners:
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS25
- Small ribosomal subunit protein mS23
Sequence:
MARRKVRPRLIAELARRVRALREQRERPRDSVRYALDYETLIRPHSGRKLPLRAWVDVRRESRLLQLLGRLPFFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYTAQNLDHGKAWGILTFKGKTESEAREIEQVMHHDWRLVPKHEEAAFTSFTPAPEETPRPVPYPPLLRAMILAERQKNGDPSTEEPMLSLERIRTDPWDYPENQEAKKKTKGTAV
Protein: Protein Wnt-8b (P51029)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled class receptor 2
- Frizzled 8a protein
- Secreted frizzled-related protein 5.
- Secreted frizzled-related protein 1
- Low density lipoprotein receptor-related protein 5
- Catenin beta-1
- Frizzled-5
- Frizzled-3
- Secreted frizzled-related protein 2
- Frizzled class receptor 1
Sequence:
MFMHLEVYYYAFILMAHMKTCCGWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWKCPERALQLSTHSGLRSANRETAFFHAISSAGVMYTLTRNCSLGDFDNCGCDDTRNGQRGGQGWLWGGCSDNVGFGEVISKQFVDALETGQDARAAMNLHNNEVGRKAVKGTMQRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKYHRAVKVDLLRGAGNSAASRGAIAETFNSISRKELVHLEDSPDYCLENRTLGLPGTEGRECLRKGKNLSKWEKRTCKRLCGDCGLAVEERRAETVSSCNCKFHWCCAVKCEQCRKTVTKYYCVKRSKRVKNDNASRRKSYRLKKKH
Protein: Intracellular chorismate mutase (CM) (EC 5.4.99.5) (P9WIC1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phospho-2-dehydro-3-deoxyheptonate aldolase AroG
- Anthranilate synthase component 1
- Secreted chorismate mutase
- Chorismate synthase
- Prephenate dehydrogenase
- Prephenate dehydratase
- Anthranilate synthase component 2
- Putative isochorismate synthase MenF
- HTH-type transcriptional regulator Rv0880
- Salicylate synthase
Sequence:
MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (Q5BEU9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- High osmolarity signaling protein sho1
- MAP kinase kinase kinase
- Mitogen-activated protein kinase hog1
- mitogen-activated protein kinase kinase kinase
- Mitogen-activated protein kinase mpkC
- Mitogen-activated protein kinase
- Uncharacterized protein
- Cytoplasmic response regulator
- Type 2C protein phosphatase
- mitogen-activated protein kinase
Sequence:
MSAEHDFAAENPPVSPHSDGDSAPVTLEDEVSSPNTKTIPVLRSTSDKVSGITPSSTHIGQVNAARYGGGGGGINTRPQASIGSASQDILAKMKAFQLSRQGVPPNLNQSVSTGAISQGGQQSTPSVSGPLSGNNSPSAMNGPLAPTASGRLPPTHRPGPPKNWASAPTVGGGSPVSGSPKGGLAAKRMKPGLKLSDATGPSNPAAGGQSPAGGPIGGGESAFSKYSEYIDTKSGTLKFKNKAVLHGGGIEFSSGQSFSISLDEVDRMDELGKGNYGTVYKVRHSRPHMRKPGQGLSGIVSRPQGSDGSDTELKPQDSLTGAVMAMKEIRLELDESKFAQIIMELDILHRCVSPFIIDFYGAFFQEGAVYICVEFMDGGSVDKLYGDGIPENILRKVALSTVMGLKSLKDDHNIIHRDVKPTNILVNTRGQVKICDFGVSGNLVASIAKTNIGCQSYMAPERIAGGGVQQSGASGGTYSVQSDIWSLGLSIIECAIGRYPYPPETFNNIFSQLHAIVHGEAPNLPESEYSEDAHSFVRACLDKNPQKRPTYNMLIRHPWLSSLMQPPDSDNPDVPSVSLADGASGDVTPPVTDDQEVADWVKDRLEKRLNGLLKDETKPALHAVPLDAVPGSPLLDDPPIANLSLASSMPE
Protein: Pectin acetylesterase (EC 3.1.1.6) (E0SAZ4)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- Pectinesterase A
- Exo-poly-alpha-D-galacturonosidase
- Exo-poly-alpha-D-galacturonosidase
- Pectate lyase D
- Polygalacturonase
- Exo-poly-alpha-D-galacturonosidase
- Xylosidase/arabinosidase
- Pectate lyase L
- Exopolygalacturonate lyase PelX
- Pectate lyase
Sequence:
MLTTTWNRAFFLGSLLCLPISFAQAEGTVTETNASPTSPVLNVVTLAPNTSISGRVAYRDIRFPATLLIKDQHGVERSVKTDIQGRFYVDVSSLVTPLRLSAIEAGGQNCLLSNQLRAVCLGALVPELRDGHENRININPLTDRILSEVAVSAGYIGPQQLIDAATLPSLSTTVWETAYREFHVGFDDALKQAGIADPSQFDPLTYSDTMTPAFTKILQVINHTRGYNNNNGQASHTVLTDIKFRPIAGLNASGSYEPLDLTSANQHRKALEQSHTRIFIVSDSTAATYEKARFPRMGWGQVFEQQFRPGGDVTVVNGARAGRSSRDFYYEGWFRQMEPFMRPGDYLFIGMGHNDQNCDSQKALRGAADVANLCTYPNSADGRPQYPQGKPDMSFQISLERYIRYAQAHRMIPVLLTPTARVKNAEGKNGTPAVHSHLTKQNKAGGYAYIGDYTQTIRDTASKNKVPLLDVETATLALANQGDGQQWQQYWLAVDPDRYPYYRDQAGSLTQPDTTHFQQKGAQAVAAIVADQIKATPSLRELAGKLQAANR
Protein: Extracellular serine/threonine protein kinase four-jointed (EC 2.7.11.1) [Cleaved into: Protein four-jointed, secreted isoform] (P54360)
Organism: Drosophila melanogaster (Fruit fly)
Function: Golgi serine/threonine protein kinase required for intermediate growth in the proximal-distal axis. Phosphorylates specific residues within extracellular cadherin domains of Fat (ft) and Dachsous (ds) as they transit through the Golgi. Acts in ommatidial polarity determination as a secondary signal downstream of Notch, JAK/STAT and wingless. Also necessary for the initiation, up-regulation or maintenance of Notch ligand, Serrate (Ser) expression in legs, thereby participating in a feedback loop with N signaling. Sufficient for joint formation and growth in the leg.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11566858, ECO:0000269|PubMed:14757640}; Single-pass type II membrane protein {ECO:0000269|PubMed:11566858, ECO:0000269|PubMed:14757640}. Note=Golgi apparatus, in the wing pouch.; SUBCELLULAR LOCATION: [Protein four-jointed, secreted isoform]: Secreted {ECO:0000305}.
Interaction partners:
- Protein dachsous
- Cadherin-related tumor suppressor
- Dachs, isoform E
- Protein prickle
- Vang-like protein
- Protein espinas
- Diego, isoform A
- Frizzled
- Frizzled-3
- Segment polarity protein dishevelled
Sequence:
MYDIKRLEAGQQKLQQAQQPLGLDLSGQQQQLTCSVITAPEHRANPNPSSISQSNPSEATHMTLLTLRRRRSLQRRACLLSILAAFVFGMALGVVVPMFGLPRHQDSPPDLPEEQIQMVAVEPLSSYRVEFIKETDELSAEQVFRNAFHLEQDKDAPDSMVVKKLDTNDGSIKEFHVQRTASGRYRKGPERRLSKKMPERVQPQETSRSPTTSPTNPTSEHQAGFIEEDVYWGPTVEQALPKGFAAKDQVSWERFVGEQGRVVRLEQGCGRMQNRMVVFADGTRACARYRQNTDQIQGEIFSYYLGQLLNISNLAPSAATVVDTSTPNWAAALGDITQAQWKERRPVVLTRWLSDLEPAGIPQPFQPLERHLNKHDVWNLTRHMQSERQAQSQPHGLLKRLGAASSPGSAHQSNAIEETGTGTETANGALVQRLIELAQWSDLIVFDYLIANLDRVVNNLYNFQWNADIMAAPAHNLARQSASQLLVFLDNESGLLHGYRLLKKYEAYHSLLLDNLCVFRRPTIDALRRLRAAGAGRRLRDLFERTTSAGVRDVLPSLPDKSVKILVERIDRVLGQVQKCQGS
Protein: Uncharacterized protein DDB_G0270306 (Q55BY9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Uncharacterized protein csb family protein DDB_G0271196
- RING zinc finger-containing protein
- Probable myosin light chain kinase DDB_G0282429
Sequence:
MIVNQALIELTKQVAVAVEEIKFSPNSTSNNSTPTNNKLKSSSSSISNCDSPSSKSKSNSSTSTPTSQPQTPSQLPQQAQQQAQQQHYSANSMNPYYAQQVLLQLQKPSTFVKHVHVVVKNTPFGITLRSKEPLQFNFQNYVIKATLLYDSDPPKMVDFIHNEPLQYVATVSEDGSEVCVDVKVGILSSQHQGSMFLVVLHISHCSAPTPSNSEPISTILTNIGNNSIHSLNVTNICVVSHPIRIVSKLDHVKKEGIPILKKRTFHEILTDKLKKLQKSQDSQSKWIKNLYQQHGAQYDMEPYNSTLHSQKTDSLCSSSTSTPSFNSTSSSSKNQSQSIKNEEEEDGGEDEEEEGGEDNDNESESSNTNSTQLIGKKSINKLPISTTTSSSNFNNLMVNNNINNNNNNNNNNHLIQNTTFSSTSHFQNSFNRVVEVYNLIPEYERVEVIRKMVQQLKSYDLEQLVSTFIDELKCGYESTIIS
Protein: LD21682p (Q95TU4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MSCIELTEIGHKPDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESWREHNLYKDIIGEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKDQEFPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHSLNDCINAHGKLNHNENIVFGVKEQQVKKIDITKACIMSSDIKLIHEADVILDDICSHLGSDWPLLANVLGVSQADIDLVKTEFLLNDSVKQSMAMLQLWLEHGGILTGNVLAEALYKIGRSDIVEKSFKNAEFGTHQPEKVLPTAGIEKDGDYEQ
Protein: Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) (Q9NQW7)
Organism: Homo sapiens (Human)
Function: Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11106490}.
Interaction partners:
- Cytosol aminopeptidase
- Xaa-Pro aminopeptidase 3
- Kininogen-1
Sequence:
MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGRQEALEWLIRETQPISKQH
Protein: MYO1B variant protein (Myosin IB, isoform CRA_a) (B0I1S9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP
Protein: Transcription factor prr1 (Pombe response regulator 1) (O14283)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in oxidative stress. Transcription factor that acts upon trr1 and ctt1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Multistep phosphorelay regulator 1
- Heat shock protein 90 homolog
- Mitogen-activated protein kinase spk1
- Translation initiation factor eIF2B subunit epsilon
- Tuberous sclerosis 1 protein homolog
- NAD reductase coq12
- Heat shock factor protein
- Hydrogen peroxide stress regulator 1
- Catalase
- Protein lsd90
Sequence:
MPSSNGSSDFVRKLFNMLEEPEYRHILRWSDSGDSFIVLDTNEFTKTILPRHFKHSNFASFVRQLNKYDFHKVRHEEGAPSIYGEGAWEFRHDDFQLHHKDLLDNIKRKAPSKRNLANENTAPVIENLKQQVDSILDFQKLLDRNLSGLATSYQTILLKMFELKRGIESRDLLMSSIISYLCDLEGSTQRQANPGAMFVPSHPLQELLNAYQALAKGQVATTSPQQIPNQIQQASAATTASSKMTVDTNLGTAQPSLYNTPSSDYELANQEKPADSMASAASLNTPLSSNDHSLNPHAHGSYPMYEKFQPIQHPNPGSFTTHLDSNASMAKSFSQISNDSLAKASSVATSMSQMGAAVPTTGLWKRQPRILLVEDDELSRRMTIKFLTSFDCQVDVAVDGIGAVNKANAGGFDLILMDFILPNLDGLSVTCLIRQYDHNTPILAITSNISMNDAVTYFNHGVTDLLVKPFTKLTLLQLLKKQLLNLLQADNSINMSDVPSTKEAKDDKAPVTFYLENDAPMYPQQMLQDPIQADLQHPH