wanglab/gogpt-training-data huggingface dataset:
Protein: Stellate protein CG33237 (Q7KV13)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
Interaction partners:
- Casein kinase II subunit alpha
- Casein kinase II subunit beta
- Segment polarity protein dishevelled
- Ste:CG33242
- Stellate protein CG33243
- Stellate protein CG33239/CG33241
- Stellate protein CG33236/CG33240/CG33244/CG33245
- Stellate protein CG33238
- Stellate protein CG33246
- Stellate protein CG33247
Sequence:
MSSSQNNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDEKKWYGMIHARYIRSERGLIAMHRKYMRGDFGSCPNISCDRQNTLPVGLSAVWGKSTVKIHCPRCKSNFHPKSDTQLDGAMFGPSFPDIFFSLLPNLTSPLDDPRT
Protein: Cytochrome P450 monooxygenase (D4QC39)
Organism: Aspergillus oryzae (Yellow koji mold)
Interaction partners:
Sequence:
MNVRIIMLSFLPLPGPFSSPVGTVGFYLGLGVLLSILYLFAVIIYNVYFHPLAKFPGPKSYAATRIPYFQALLGGQIGQAIKDLHQKYGEVVRIAPNELSFIDGEAWKAIYGTRPGHKQKPKDVRYYPPTAGGVPSIVISNDEDHSRFRRTLSHAFSETSLRVQEPLVNSYIDLLIQRLHEHCEAGNKPLDMVAWYNFTTFDIIGDLAFGEPFNCLQNSAYHKWVSMIFSNIRYGTYGNLARRFPGSKFLLRLITPTRIANGRNWHIELTKEKVKDRLAKSNDRMDFYGHILKQKDTERAMTFDEMVTNGSTLIVAGSETTATLLSAVTFYLLKNERVLSKLQQEIRASFESEKDITVTGCNQLEYLNAVLTEGLRIFPPTPTGLPRIVDADGDMIAGKWVPGGTIVSIPHLAAFHSASNFTEPESFIPERFLGDPRFANDSKTVLQPFSFGPRNCIGRNLANAEMRLILARVLYNFDLELDERSENWSRQETYILWNKPGLYVRLRPRVGI
Protein: Uncharacterized protein, isoform D (A0A0B4KEQ6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MLVGIAGFVAAGLIGAYKYRNRGSMSTSVFLMQLRVAAQGTVVGCLTAGLAYTMAKEYLLHEEPKSNTRPDE
Protein: At1g17490/F1L3_4 (Epidermal patterning factor-like protein) (F1L3.19) (Q9LNQ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEPKQSSLSEVKTNVIGSRKEEKESMFHGKETHGRSEDIDEKTRVDDVKGPGVLGRMMEEMEAIVDAVTPNKSSDK
Protein: Glutaredoxin-C7 (AtGrxC7) (Protein ROXY 1) (Q96305)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). Involved in flower development as a regulator of petal primorida initiation and further petal morphogenesis. May mediate post-translational modifications of target proteins required for normal petal organ initiation and morphogenesis. ROXY1/TGA protein interactions can occur in vivo and support their biological relevance in petal development. May be involved in the regulation of the floral regulator class C gene AG (AGAMOUS).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P17695}. Nucleus {ECO:0000269|PubMed:19218396, ECO:0000269|PubMed:20805327}.
Interaction partners:
- Transcription factor TGA9
- Transcription factor TGA10
- Transcription factor TGA2
- Transcription factor TGA1
- Transcription factor TGA3
- Transcription factor PERIANTHIA
- Monothiol glutaredoxin-S17
- Transcription factor TGA4
- SNARE associated Golgi protein family
- Transcription factor TGA5
Sequence:
MQYQTESWGSYKMSSLGFGGLGMVADTGLLRIESLASESAVVIFSVSTCCMCHAVKGLFRGMGVSPAVHELDLHPYGGDIQRALIRLLGCSGSSSPGSLPVVFIGGKLVGAMDRVMASHINGSLVPLLKDAGALWL
Protein: Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) (Q8NBU5)
Organism: Homo sapiens (Human)
Function: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:24843043}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:24843043}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5T0}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycophorin-A
- Dynamin-like GTPase OPA1, mitochondrial
- Endogenous retrovirus group 3 member 1 Env polyprotein
- Syncytin-2
- Cytochrome P450 1A1
- Mitochondrial import receptor subunit TOM70
- Peroxisomal biogenesis factor 19
- tRNA endonuclease ANKZF1
- Syncytin-1
- Peroxisomal membrane protein PEX14
Sequence:
MVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQNVLTHVCLD
Protein: SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (O70143)
Organism: Rattus norvegicus (Rat)
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Interaction partners:
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Growth factor receptor-bound protein 2
- Receptor protein-tyrosine kinase
- High affinity nerve growth factor receptor
- SOS Ras/Rho guanine nucleotide exchange factor 2
- BDNF/NT-3 growth factors receptor
- Proto-oncogene tyrosine-protein kinase Src
- Receptor tyrosine-protein kinase erbB-2
- Insulin-like growth factor 1 receptor
- Receptor tyrosine-protein kinase erbB-4
Sequence:
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAEPAASPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGGSATPGSRAPAASMSATRKSRASDEPLPRPPRGAPHASDQVLGSGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIISNHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKIPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPNKMPPPGGFLDARLKARPHAPDAAQFSGKEQTYYQGRHLGDAFGEDWQRAPTRQGSLDIYSTPEGKAHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPVLSKAASVECISPVTPRAPDAKMLEELNAEPWYQGEMSRKEAEALLQEDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTVRTKDRVFDSISHLITYHLESSLPIVSAGSELCLRQPVERKP
Protein: MADS-box protein AGL42 (Protein AGAMOUS-LIKE 42) (Protein FOREVER YOUNG FLOWER) (Q9FIS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MADS-box transcription factor that acts with AGL71 and AGL72 in the control of flowering time. Promotes flowering at the shoot apical and axillary meristems. Seems to act through a gibberellin-dependent pathway. Interacts genetically with SOC1 and its expression is directly regulated by SOC1. Plays a role in controlling flower organ senescence and abscission by repressing ethylene responses and regulating the expression of BOP2 and IDA.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Protein LEAFY
- Squamosa promoter-binding-like protein 3
- COBRA-like protein 9
- Squamosa promoter-binding-like protein 8
Sequence:
MVRGKIEMKKIENATSRQVTFSKRRNGLLKKAYELSVLCDAQLSLIIFSQRGRLYEFSSSDMQKTIERYRKYTKDHETSNHDSQIHLQQLKQEASHMITKIELLEFHKRKLLGQGIASCSLEELQEIDSQLQRSLGKVRERKAQLFKEQLEKLKAKEKQLLEENVKLHQKNVINPWRGSSTDQQQEKYKVIDLNLEVETDLFIGLPNRNC
Protein: Signal-regulatory protein beta 1A (A0A0A6YWR3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLLLDAWTHIPHSVLLLILLLGFKDVTKRNNMDFSIRISNVTPADSGTYYCVKFQRGSSEPDIEIQSGGGTELLVLAKPSSPMVSGPAARAVPQQTVTFTCRSHGFFPRNLTLKWFKNGDEISHLETSVEPEETSVSYRVSSTVQVVLEPRDVRSQIICEVDHVTLDRAPLRGIAHISEFIQ
Protein: Ubiquitin-activating enzyme E1 (EC 6.3.2.19) (Q8I5F9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Ubiquitin-60S ribosomal protein L40
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin-conjugating enzyme E2, putative
- Polyubiquitin
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2
- Ribosomal protein S27a, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
Sequence:
MQNKTPPLKKQRTDESVKPIEFDKSSESWKRSDCLEKMTENKIDTDLYSRQLGTYGFDLMNKLVKLNILIINVKGVGLECAKNLILSGPQSVCIYDNDICDISDIGVNFYINEKDVEDKSCRSDAVLKELQELNNYVHIYNYKGTIEKNWLENFDVVICCDINKEDLIKYNNMIRGIDKKRIAFLSCNIYGLCGYIFVDFNKEFICYDSNGEQVKSCNVSKISKELEGKVSFDFDKTSPFEEGDYVQFSNVEGMTEINNKIYKIKNLKKYTFEIGDTSLYSEYIKGGICTQVKKHLKLNFYPYEYICVNPLNNENISNNEQKHNQNDNHFLDTCNNIIYENIPQPNSFIISDYAKFDMSNHLHYSIQALKWYELQNEKGLPENSDEDALEKIYNYAVTLNNKDKEEKKSYAVEQLKKDVVYNVCRYSKSHIAPVASFFGGLLAQEVIKFTGKYMPIYQLLYLDFFECISLNEKVDINEIKKMNCKNDNIITVFGKSFQKKLNNLNVFLVGSGALGCEYAKLFSLLDMCTRNSEQNTNLNQNNIDNNLACCGKLTITDNDNIEVSNLNRQFLFRREHVGKSKSLVSSEIIKKKNNNMHVQSLETKVGAENEHIFNEEFWTKQNIIVNALDNIQARQYVDNKCVWYSKPLFESGTLGTKGNVQVIIPYLTQSYNDSYDPPEDSIPLCTLKHFPYDIVHTIEYARDIFQGLFYNTPLSIKQFLNDKEEYINKIQEEGNNASLLENLQNVINSLKEISSQCNFDFCIKKSVELFHNNFINQINQLLYSFPLDYKLSSGEYFWVGQKKPPQPIVFDVNNEMIQEFLLSTSNLLAQVYNIPPCFDINYIINVAKKIEVKPFEPKKVKINMDEKNLNNISISFAEEEKIIDDFCKELLNIPTNNIKINPIEFDKDEQTNLHVNFIYAFSNLRAINYKINTCDKLKAKIVAGKIIPALATTTSIITGLVGIELLKYVNYYDNIQAYVKLSDEQRKKEKHDVLSYFKNAFINSALPLFLFSEPMPPLRMMDKEYDELMKGPVKAIPNGFSSWDKIVISIKNGTIKDLIDHINEKYSIDVNLISVGNACLYNCYLPAHNKERLNKPIHELYKQISKQDLLEDKNYIIVEASCSDQDLVDVLIPSIQFIYK
Protein: dual-specificity kinase (EC 2.7.12.1) (A0A0R4II39)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSQHSHPSFSNIHSMADQQQVLSDMTILQRRIPPSFRDPASAPLRKLSVDLIKTYKHINEVYYTKKKRRAQQVPPEDSSTKKERKVYNDGYDDDNYDYIVKNGEKWLDRYEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGVPPNHMLDQAPKARKYFDKLSDGLWTVKKNKDIKKVLYPSASEYKPPATRRLHEILGVETGGPGGRRAGEQGHAPCDYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTSSSTSTSPAMDHSHSTSTTSSVSSSGGSSGSSNDNRNYRYSNRYYNSAVTHTDYEMQSPQAPSQQQLRIWPGGDSSMGQLSNSGSDSSYPQLLLHKPAATQHSRHFLGNIGGMMEPHHPHPIYGSHHSNGRQLRQQQQQQNQPQGQASQGQQGTALMPVSSPQMQDSIELSLTHHHHLGQSSIMQPPPSSLDSSQYGSSNLHLGLSAFRTRTESSMMAVCGSGSGSGQSAANS
Protein: F420-dependent glucose-6-phosphate dehydrogenase (FGD) (FGD1) (G6PD) (EC 1.1.98.2) (P9WNE1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. More precisely, is likely involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents.
Interaction partners:
- Phosphoenolpyruvate transferase
- Bifunctional F420 biosynthesis protein FbiB
- Deazaflavin-dependent nitroreductase
- FO synthase
- Phosphoenolpyruvate guanylyltransferase
- Putative F420H
- F420H
- Phosphate acetyltransferase
- Acetate kinase
- F420H
Sequence:
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG
Protein: Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (A6QP74)
Organism: Bos taurus (Bovine)
Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q16602}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16602}.
Interaction partners:
- Receptor activity-modifying protein 1
- Receptor activity-modifying protein 3
- Receptor activity-modifying protein 2
- Pro-adrenomedullin
- Calcitonin
- Calcitonin receptor-stimulating peptide 1
- Islet amyloid polypeptide
- Calcitonin-related polypeptide 3
- Uncharacterized protein.
- Calcitonin receptor
Sequence:
MEKKFFLSFLFLLPFFMILVIAESEEENPDDLIQLGVTRNKIMTAQYECYQKIMQDPVQQTEGIYCNRTWDGWLCWNDVAAGTESMQHCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHVLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVITIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLVVVAVFAEKQHLMWYYFLGWGFPLIPACIHAVARRLYYNDNCWISSDTQLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEIYDYIINILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNNFSHSDTLRSASYTVSTISDGTGYSHDCLSEHLNGKSIHDTDNVVIKPEKLYD
Protein: Nucleic acid-binding, OB-fold-like protein (Putative methionyl-tRNA synthetase) (Q93VB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glutamate--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, cytoplasmic
- glutamine--tRNA ligase
- Glutamine--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, cytoplasmic
- Arginine--tRNA ligase, chloroplastic/mitochondrial
- Lysine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, cytoplasmic
- Methionine-tRNA ligase
- ATP binding / aminoacyl-tRNA ligase/ nucleotide binding protein
Sequence:
MDSKAKQMILSALCKHFSLDPEPFVGGAGESDIKTLYSNVLKASGKEVSAQNNDVLKWLDFAEGFSSDSKDWFSALEKLNLELATKSVLLGNGLTPSAADVAVFSALHSSVLGLSDSDKEKVPHVIRWVNYIQNKEELSTLFAPIPVKLPEFSFEVPKPAIKVETNSNSKKAAEGVKPVDKPDVQPQLGTKKTEPEEPKKNAAKEKDAKKEKKKPAEPEPAKKEAELSVSLLNIQVGLIRKAWKHPSADSLLVEEIDVGEDKVRQVVSGLAKFCSPEDLTNRLVALITNVKPGKLRDVMSQGLVLCASSEDHSVVEPLLPPAGAKPGERVSFSGIEGKPEDVLNPKKKQLEKITPGLYTDENGVATYKGIQFMTSAGPCTSSIPKATIK
Protein: cytokinesis protein 3 (O14302)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cytokinesis.
Subcellular location: Cell tip {ECO:0000269|PubMed:16823372}. Note=Also at the division site. {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cell division control protein 15
- Septation protein imp2
- Chitin synthase-like protein 2
- Ingression protein fic1
- LIM domain-containing protein C4F6.12
- GTP-binding protein rho1
- Uncharacterized protein C3G9.05
- Actin
- Myosin type-2 heavy chain 1
Sequence:
MSIPKQLPCMVRALYAWPGEREGDLKFTEGDLIECLSIGDGKWWIGRHINTNTQGIFPSNFVHCLDIPTVRPGSSMSRTSASSFRYSSPQKSSIDTPITSSDQGLTPDLVGSSNALNKPTRESDSLKHQKSHPMLNSLGSSLSLKKSVSRPPSSMSRTNLDVSSRWDNTADNDSQIDAQDLSRSTPSPLRSAMENVLQSLNAMGKKSFSRANSPLLRLTKSTTTSKETDFIPVPPAHGSTSMTSRSKLDDSTDNSSKPRTSLQPGESPMKSSRDISRKPSMASSVLSPSDYFPQHRRFQSAPAPIPRPVSTLIPLTQVRTTASNVIKPRPQTTERPSTAQSFRKGGGFLKKTFKKLLRRGSSKRKPSLQPTPPVSYPAHNVPQKGVRPASPHTLKSVKDDLKRTKTYTKAEFAAKREEIFNKLSMPVYEPLKDLSECIGNVLADGEPVQFSVGTNIHNMNFSAIDKQIRSIIPQRVQVSPAVLAKNYLAPGQTTALAQMRAVFIYISERITFTNQTLDNDELRTSTQVISEGQGTPFEVALLVKEMLQALDLWCEVIEGYLKSPDDIYYTRDININHAWNVVTFDNEVRLIDASFASPTHPQQALKSSSSNDFYFLMKPNECIFTHVPENPDQQFIMPDLSMPIVMALPWVSSVYFTLGLKLRKFNTSILHLNDLEVLQIEFLAPKDIECVAEVDALSALAPTADVSQCYKYTLTQAFWETPDIRVMRVKAVMPANNRAAVLRIYAGRLGVSSPVRTAPHPMAMSLPFVHHGKNKALEFVTRHPVPHCPSVDLYINSPQCGTLHSGVEYKFNVSAYACQPSTSISNTRLAIQTPTGNIVRLREERSGNGVIFFSLSLTINETGEYRALILAEKIGRWVVYATWQAV
Protein: Equilibrative nucleobase transporter 1 (Embryonic epithelia gene 1 protein) (Solute carrier family 43 member 3) (A2AVZ9)
Organism: Mus musculus (Mouse)
Function: Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (By similarity). May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q8NBI5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTCATIIIAFTSANTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITLYNGAFDSSSAVFLVIKLLYEQGISLRSSFIFMSVCSVWHIARTFLLMPKGHIPYPLPPNYSYGLCSRFGASKKENKAAEHETKELRSKECLPPKEENSGPEQQQQQEQQQQQQQQQEQHEQHSFRRCALSRRFILHVVWLSIIQLWHYLFIGTLNSLLTKLSGGDKVEVSAYTNAFAITQFFGVLCAPWNGLLMDRLKQKYQKAAKRTGSSSEAVALCSMVPSLALTSLLSLGFALCASIPVMQLQYATFILQVVSRSFLYGCNAAFLTLAFPSEHFGKLFGLVMALSAIVSLLQFPLFKVSPESNAVYVSMGLAIFLTLVHPFLVYRECRAEKTKSSVDA
Protein: Cation channel sperm-associated protein 1 (CatSper1) (Q91ZR5)
Organism: Mus musculus (Mouse)
Function: Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:34998468}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000269|PubMed:34225353, ECO:0000269|PubMed:34998468}.
Interaction partners:
- Cation channel sperm-associated auxiliary subunit beta
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated protein 3
- Cation channel sperm-associated protein 4
- Cation channel sperm-associated protein 2
- Cation channel sperm-associated auxiliary subunit gamma 2
- Cation channel sperm-associated auxiliary subunit zeta
- Cation channel sperm-associated auxiliary subunit epsilon
- Solute carrier organic anion transporter family member 6C1
Sequence:
MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK
Protein: Uxu operon transcriptional regulator (P39161)
Organism: Escherichia coli (strain K12)
Function: Repressor for the uxuRBA operon.
Interaction partners:
- D-mannonate oxidoreductase
- Probable HTH-type transcriptional regulator LgoR
- Mannonate dehydratase
- HTH-type transcriptional regulator UidR
- Hexuronate transporter
- HTH-type transcriptional repressor RspR
- Uncharacterized HTH-type transcriptional regulator YieP
- Uronate isomerase
Sequence:
MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDNSGSQNTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDIYFDGYLFDSWPLDKVDA
Protein: Translation initiation factor IF-1 (P9WKK3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00075}.
Interaction partners:
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS4
Sequence:
MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLSRGRIVYRYK
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (NADH-ubiquinone oxidoreductase B22 subunit) (A0A3B3IT57)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
Sequence:
MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVY
Protein: Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (Q8VEC3)
Organism: Mus musculus (Mouse)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5T601}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRIGLLWLVPLFTLTEGTDGFLQQKNDGRRTKEIVSMVEERHPVHEYEVLLQVTYRDPEEKRELKRFLKLLKSPSPSLRGPSKIIRVKATTYCRSRKGFLECACEDSYTWFPPSCLDPQNCCLHTTGPVPSCNCSLRGLRQSINFCERAKVWGTFEIDEKFPEDLWNSSSDVYAHYTVGIENQLKEAYRRVHGFESVRVTQFRKGSIVVGYEVTGSTSPPELLFAIEQEAEKAQEALRRQFPVKYGSFRVFGKAPCNSISFGFGSENDEYTVPCSSGFTGSMTVRCQSSGWQITRESCVLSQLEELKKELRMIAGKITEAGVASLVQNLSTILLQSPSTTVGNLGSVVSLLSNISSLSLANSLTVSNLTLMNVINIADHILDSASITNWTILLQDAKDASSQLLKTLESISSLIPSMALPLNFSGKFIDWKGTPVTQIQSTRGYNYQMEMRQNASLPIRGHVFIEPDQFQKSHPKTIISMASLTFGDILPITQRGNAWVNGPVISTLIQNYSISEIFLNFSKIKGNLTQPRCVFWDFSQLQWSNAGCQLVNETLDTVLCRCSHLTSFSMLMSPFVPSSVVPVVKWITYIGLSISIASLILCLIIESLFWKQTKRSQTSYTRNICLVNIAVSLLIADVWFIIAATVDPSVSPSGVCVAAVFFTHFFYLAVFFWMLVLGILLAYRIILVFHHMALTTMMAIGFCLGYGCPLLISIITLAVTQPSNSYKRNDVCWLNWSDKSKPLLAFVVPALTIVAVNLVVVLLVLRKLWRPAVGERLNQDDKATAIRMGKSLLVLTPLLGLTWGFGIGTMANSHNLAWHVLFALLNAFQGFFIFCFGILLDTKLRQLLSNKLTTLSSWKQTSKRNASDTVTQPKCLRTFNILQHRGMYALSHTGDSSSDITLTQFLSTE
Protein: Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) (Q96FI4)
Organism: Homo sapiens (Human)
Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin.
Interaction partners:
- Endonuclease 8-like 2 lyase Neil2)
- Endonuclease 8-like 3
- N-glycosylase/DNA lyase
- DNA repair protein XRCC1
- Endonuclease III-like protein 1
- Flap endonuclease 1
- DNA polymerase beta
- Transcription factor Maf
- Bifunctional polynucleotide phosphatase/kinase
- DNA ligase 3
Sequence:
MPEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASARGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEALQQHRPSPELTLSQKIRTKLQNPDLLELCHSVPKEVVQLGGKGYGSESGEEDFAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLAPKGRKSRKKKSKATQLSPEDRVEDALPPSKAPSRTRRAKRDLPKRTATQRPEGTSLQQDPEAPTVPKKGRRKGRQAASGHCRPRKVKADIPSLEPEGTSAS