wanglab/gogpt-training-data huggingface dataset:
Protein: tRNA modification GTPase MnmE (EC 3.6.-.-) (P75104)
Organism: Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00379}.
Interaction partners:
- tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein bL21
- Probable GTP-binding protein EngB
- Probable ribosome biogenesis GTPase A
- Uncharacterized tRNA/rRNA methyltransferase MG252 homolog
- Large ribosomal subunit protein bL17
- Acyl carrier protein homolog
- DnaJ-like protein MG002 homolog
Sequence:
MDTKQTMFALATAPFNSAIHIIRLSGPDVYRIINQITNKEVKPLGMRIQRVWLIDHNQKKVDDVLLFKFVAPNSYTGEDLIEISCHGSMVIVNEIIGLLLKHGAVQAQPGEFTQRGYLNGKMSLNQAASVNNLVLSPNTTLKDVALNALAGQVDARLEPLVEKLGQLVMQMEVNLDYPEYTDEQRELVTMNQAVVQITQILNQIVVGQDQLQRLKDPFKIAIIGNTNVGKSSLLNALLDQDKAIVSAIKGSTRDIVEGDFALNGHFVKILDTAGIRQHQSALEKAGIQKTFGAIKTANLVIYLLDARQPEPDPKIIARLKKLKKDFFLVHNKADLVQQSFQVSISAKQKQIQPLVDLLTQYLHQFYSVEQNQLYLISDWQTILLQKAIAELEHFLIKQQNCLFFDILVVHLRAAHEYILQVLGKNTNYDLINEIFKHFCLGK
Protein: Homeobox protein lin-39 (Abnormal cell lineage protein 39) (P34684)
Organism: Caenorhabditis elegans
Function: Transcription factor that binds to the consensus 5'-TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Regulates vulval precursor cell (VPC) differentiation, in concert with orphan nuclear receptor nhr-25.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein mab-5
- Homeobox protein ceh-20
- Homeobox protein unc-62
- Protein lin-3
- Transcription factor elt-6
- Homeobox protein php-3
- Abnormal cell migration protein 13
- GATA-type domain-containing protein.
- ETS domain-containing protein
- Beta-catenin/armadillo-related protein 1
Sequence:
MTTSTSPSSTDAPRATAPESSSSSSSSSSSSSSTSSVGASGIPSSSELSSTIGYDPMTASAALSAHFGSYYDPTSSSQIASYFASSQGLGGPQYPILGDQSLCYNPSVTSTHHDWKHLEGDDDDDKDDDKKGISGDDDDMDKNSGGAVYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKENKDKPMTPPMMPFGANLPFGPFRFPLFNQF
Protein: F-box/SPRY domain-containing protein 1 (DFsn) (Q9V6L9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20123973}. Nucleus {ECO:0000269|PubMed:17697379}. Synapse {ECO:0000269|PubMed:17697379}. Cell projection, axon {ECO:0000269|PubMed:17697379}. Perikaryon {ECO:0000269|PubMed:17697379}. Note=In mid- to late-stage oocytes, recruited to the pole plasm. This posterior distribution is not maintained in later developmental stages. Some cortical accumulation is observed at mid- to late-stage oocytes. In mature eggs, present at high levels throughout the ooplasm. {ECO:0000269|PubMed:20123973}.
Interaction partners:
- E3 ubiquitin-protein ligase highwire
- Large ribosomal subunit protein uL3m
- GEO01111p1
- GEO01805p1
- Cullin homolog 1
- Protein Rae1
- Mitogen-activated protein kinase kinase kinase
Sequence:
MVDPVAALCNYNVLEVIFSYLELDDLSHCSQVCKSWYHFLNDENSDVWRWHCLNKLPKESLKSDLLASVSTYKTKLRAYFHAWSPNDCSRNVYIKPNGFTLHRNPVAQSTDAARGKIGFRHGRHTWEVIWEGPLGTVAVIGISTKEAALQCHGYVALLGSDDQSWGWNLVENHLLHNGDMQGSYPLLNNAPKYQVGERIRVILDCEDNTLSFEKNYEFLGVAFRGLPDKKLYPTVSAVYGNTEVSMVYLGTPLDG
Protein: Homeobox protein cut-like (A0A2R8YDI1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF
Protein: Sulfur carrier protein TusA (Sulfur mediator TusA) (Sulfur transfer protein TusA) (tRNA 2-thiouridine synthesizing protein A) (P0A890)
Organism: Escherichia coli (strain K12)
Function: Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. Seems to affect the stability of sigma-S, particularly during the logarithmic growth phase.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00413, ECO:0000269|PubMed:10830496}.
Interaction partners:
- Cysteine desulfurase IscS
- Sulfurtransferase TusD
- Sulfurtransferase TusE
- Protein TusB
- tRNA sulfurtransferase
- Protein TusC
- tRNA-specific 2-thiouridylase MnmA
- Molybdopterin synthase sulfur carrier subunit
- Iron-sulfur cluster assembly scaffold protein IscU
- Sulfur acceptor protein CsdE
Sequence:
MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG
Protein: Calcium binding EF-hand protein (O16124)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVQNVALLGLALIAISASIVALPVTQNKKDHKEAAESSTPATADVETALEYERYLREVVEALEADPEFRKKLDKAPEADIRSGKIAQELDYVNHHVRTKLDEIKRREVERLRELANQAYELSNDIDRKHLKVSQHLDHDNEHTFEIEDLRKLIQKTSDDLAEADRKRRGEFKEYEMQKEFEREAQKKEMDEESRKKFETELKEKEEKHKDHEKLHHPGNKAQLEDVWEKQDHMDKNDFDPKTFFSIHDVDSNGYWDEAEVKALFVKELDKVYQSDLPEDDMRERAEEMERMREHYFQETDMNHDGLISIDEFMVQTNKEEFQKDPEWETIDRQQQYTHEEYLEYERRRQEEVQRLIAQGQLPPHPNMPQGYYAAPPPGGVAYQQAPPGAQLHYQHPDQVHAQQQQQYAQQQQQYAQQYQQQQYGNGQQPVQLQPNQVYQHAGQIPQQQQPVYQNQPVYQQQQPVYQQQQPVQQQQKPVQQPVQQQQQPVQQQQHPVQQQQQTVQQQQPVQQQQQTVQQQQPVQQQQQTAQQQPVAQQQIHNQSPPPVLNQQVPVQQQQKQHQESLNQQH
Protein: RNA binding motif protein 6 (S4R1W5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Splicing factor U2AF 65 kDa subunit
Sequence:
MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGGRDGPHGDYQGGEGPGHDFRGGDFSSSDFQSRDSAQLDFRNRDIHSGDFRDREGPPMDYRGGDGTPMDYRGRETPHMNYRDRDSHTVDFRSRDVPPTDFRGRGTYDLDFRGREGSHSDFRGRDLSDLDFRSRDQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSATTDLDFRNRDTPHSDFRGRHRTRTYQDFRGREVGPCMEFKDREMPPMDPKVLDYIQPSPQEREHSGMNMNKREESIHDHAMERPAFGVQKGEFEHSETREGETQSGTFEHESQSDFQNSQSPVQEQDKPKLSGGEQQSSDAGLFKEEGDLDFLGQQDTDYRSIEYCDVDHRLPGNQIFGYGQSKSFSQGKMSRDAQQDLQDQDYRTGPSEEKPNRLIRLSGVPENATKEEILNAFRTSDGIPVKDLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSPDFWYCKRCKASTGGHQSSCSFCKGPKEEVKQELVSYPQPQKTSIPVPSEKQPNQPRPADKEHELRKREEGQESRLGHQKRDTERYFPHSRREGLTFRRDREKEPWSGDSRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVHLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGNRNSDWSSDTNRQGQQSSSDCYIYDSTTGYYYDPLAGTYYDPNTQQEVYVPQDPESPDEEEIKEKKSTSQGKSNSKKETSKRDGKEKKDRGMTKFQESTSEGKPPLEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQAPPVQPRTAQPREEMTKKENEDDKLTDWNKLACLLCRRQFPNKEVLTKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKEKGNDRREKLQSFDSPERKRIKYSRETDSDRNPVDKEDTDTSSKGGCAQQATGWRKGAGLGYSHPGLGSSEEIEGRMRGPGGGPPGRTSKRQSNETYRDAVRRVMFARYKELD
Protein: ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (Q8MSM8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR016570}.
Interaction partners:
Sequence:
MASNKECLIIVLDVRTCAAEEVKLKSAKCVAEILKDKIVCDRKDYVSFVLVGCDTDEIKTEDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALKLQSVAATLRVARRRILLLFDFNDFPQDYEKFNEITDELLGENIDLIVGTHNISYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIVIRETRHYIKGTEITPLPENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHFWDFPALRTTKTECSEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEEKSKRAAAIVKKLFPLRYSRAWQEKLLAKEQAENGVAVKSEPAEKEIPMPSDGVGLIDPVSDFRRVLASVHTISNATERDARFQTLAADTRVVIITLLQRRKQNIGQLGELITLYRQSCIDFNTFLEYDKFAEELKKIALAKNRSEFWQDVMVDKQLGPLVLGEPTLDDELALKAYYTIENWAESGANDMEDVEM
Protein: Aggrecan a (Aggrecan core protein isoform X1) (F1QDA1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Tenascin R
- Hyaluronan and proteoglycan link protein 1
- Uncharacterized protein.
- Tenascin C
- Zmp:0000000846
- Serine protease HTRA1B
- Parathyroid hormone 2 receptor
- Brevican.
- Pleckstrin homology domain-containing family M member 3
Sequence:
MLSLLLLSMCLWVFSATASFDYIDTEPESPLRVSIPNELPLRPLMGDTLVLPCYFQDNTVNDPGAPTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGYPMTPTDASIKITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFEKAKAACIQNSAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPGVRTYGVRDVNETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLAWKGGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPHPDSRYDAFCYSETGDEGSGFFPLDLELTTDGDNGVLTVDTITESHTVISKPASTESEVQGEVVTYKPSVTTSVENPYTALDISHVLPSPPTSSVEKDPDFGSGLSQSNKTEDTMSATGVVFHYRGGNCSRYPFGFVEAQLACKSIGAVIASAQQLQAAYEAGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRSYGLRPADERYDVYCYVDKLRGQVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQGFDKCRAGWLLDRSVRYSINIPRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKEDLDLPLNESESQETVTEEKIVSISSHPALHRPEGTPIIAPSPTEPSGTEESVASSSGDLLSSGSGDQPSGSSVSSGDSSGTSSTDDLLTSGSGDQSGSGSSVTSGDYSGASGTDSLFSSGSGDRSSGSFSSSGDFSGASGTDDLLGSGSGEQPSGSFVSSGDFSGASGSGDMSSGSGSSSGSGSGLDILVTFSGIDTVFSGVGSTSGQLEEAGEGSTEILTFQLDQISGSGSGLGSGSGYSSEESGSTSDLSSSSGESGESGDLSGISSGSGFSEESSGFSGFASGIFPSGGSSDISFIDGSGIIMVDRPWMKISSFLTEQELGSGQVDFSGSGLFSGSGVSGDISGLSGEISGSSGDSSGISSDISGMSGDISGMSGDISGISGDITGMSGDLSGMSSSDHSGSGSGLAFSGVTFLGSGFTDLTEQSREQEASGLVFFGSGEGSGFRSGGYAIESGERSGDSASSDVIFFSNNDMVEMSNKPLQGMELGRGEVEYSGTVRLSSGSGDDQSVFISGHEWIPVTANTPSVKSTDPPPAELFDQGPSDLYSDTAGHLGPYLKPEEIINNLDAVPLAALSSTTETASLQRPAVVERPAVNDYLNPCEPNPCGAGVCSVKDGVGLCHCPPGLHGEECQFEVDVCHSNPCANGATCVEVEDTFKCLCLPSYEGDRCETDSHSCEKGWTKFQGNCYLHFSKRETWLDAEQRCRDLNAHLVSINTPEEQAFVNSNAQDYQWIGLNDKTVENDFRWSDGTQLQFENWRPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGNKKERYQVNSIIRYQCSENFTQRHPPVIRCMADGQWEKPKVQCIPKVKFGLHDKSVHHSHKARTALEKQL
Protein: Mitotic checkpoint control protein kinase BUB1 (O76755)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}.
Interaction partners:
Sequence:
MDFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQMEEEVRTYKGADPLGAWYTFICWIEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANAVNQELNERRLALQSLHGRRQQISNSITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYDVRLEQPFRFPTNFVAKNRPQEPWVTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYPNFARYSKPQDLDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEKRNVTVHGDFDMEETVCLPGNKMPRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQVAPKIPESPCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPKGTQKQAPVTSIWNPCSKNYRYQRRLLIPSNLQWRLVLQLCESNLSTILETSEHGTQSLATSGTTTKSTITSTSSPGSNAVSKLGSKIEENTPGQMRLQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLEDESDLCGLFGKTPPKTNIFGSSKRNFDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQPDEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSWSQSDLETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESIDFSMYIEKLPHCQLVGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFYICLEIHSRLTSEQMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVSLQLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQLKCALAEKEKYVAEAISKFNTILQK
Protein: Prestin (Solute carrier family 26 member 5) (Q99NH7)
Organism: Mus musculus (Mouse)
Function: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Subcellular location: Lateral cell membrane {ECO:0000269|PubMed:12584604, ECO:0000269|PubMed:14553901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P58743}. Note=Localized at the outer hair cells (OHC) lateral plasma membrane (PubMed:12584604, PubMed:14553901). Alters profoundly the shape of its surrounding lipid bilayer (By similarity). {ECO:0000250|UniProtKB:P58743, ECO:0000269|PubMed:12584604, ECO:0000269|PubMed:14553901}.
Interaction partners:
- Hepatic sodium/bile acid cotransporter
- Transmembrane channel-like protein 1
- Carboxypeptidase D
- Cystic fibrosis transmembrane conductance regulator
- Protocadherin-15
Sequence:
MDHAEENEIPAETQRYYVERPIFSHPVLQERLHVKDKVTESIGDKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPALIMGARRKAMRKYAKEVGNANVANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTTFPEELQRFLPQGENVHTVILDFTQVNFVDSVGVKTLAGIVKEYGDVGIYVYLAGCSPQVVNDLTRNNFFENPALKELLFHSIHDAVLGSQVREAMAEQEATASLPQEDMEPNATPTTPEA
Protein: phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Q8MLR7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- LD06050p
- Phosphatidylinositol-3-phosphatase SAC1
- Egg-derived tyrosine phosphatase, isoform C
- FIG4 phosphoinositide 5-phosphatase
- Lateral signaling target protein 2 homolog
- Putative 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase
- LD28067p)
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
Sequence:
MDITRFMNKFNEIERQLSPTSALRLSFDNISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEFNEAPVFYNGNSVLKKVENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGSPLLIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNKASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDNKYNYDKKLSELSAADDDHPLKASNMSFASLSLSAEQSSPPQALPEEINSVAVDWKPMRNVTTCSCSTPFDQFSKKTHCWRCGDIFCERCIDKNVALPGHDSGKPVPVCRGCFRQMQKQSP
Protein: Mix-type homeobox gene 1 (Mxtx1 protein) (A0JPE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MWKDSTIDATAKTSGSGAVSRSASRRKRTSFSKEHVELLRATFETDPYPGISLRESLSQTTGLPESRIQVWFQNRRARTLKCKGGKKPLWQTDLPAYNNMQTSPMQIHRKNNESSGATGTLCSPPPAYPDRIKEEMEKDAVCGCDTPSSMSISDDSGYCTPSYHQSRAIQSHMSPSPLLSPEHQMPPNWGVRYGRRSPMSSMWSPYHLEAYACNPGFFYSHSEKHNTLQPLTPVTPDSGCWEAGLDRTSPVDNPDVPRTEGQLESGVHHGPLPELPTLSLQEILGELQGDWWQGEGLNNHSTEDNHVYG
Protein: Glutathione peroxidase 1 (EC 1.11.1.9) (Cellular glutathione peroxidase) (A0A2R8Y6B6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA
Protein: Methyltransferase type 11 domain-containing protein (Q54D70)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MTETNIDINSLNIKEKEEKEEGLIKDKSKKELKKLQKQQYKQQKKQEKKNNKVNKVINEGVPEISDEKINFSEPKTDREAYQVEVKHVREIYDRIALHFDSTRYKAWPIVENFLGKVEIGSIGIDVGCGNGKYLGINKDSHLIGSDICNNFASICNEKHYESLVADNLYLPYKSDSFDYAISIAVIHHFSTFERRTEALREIIRVLKSGSTLLITSWAMTQKWKGKNYDYQDVMVPWLFQNQFDMTKKQQQQQQQQDENQRDENNNNNSNNNNNNNNNNNNNNNNNNNENEEDKIIEKSGSQYEVYHRYYHLFEDGEFEKMVSQIPECEMVENNLDHDNYYCFIKKK
Protein: Bacterioferritin BfrA (Bfr) (EC 1.16.3.1) (P9WPQ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:24855650}. Note=Unlike its homolog BfrB, is not found in encapsulin nanocompartments. {ECO:0000269|PubMed:24855650}.
Interaction partners:
- Bacterioferritin BfrB
- Multidomain regulatory protein Rv1364c
- Coproporphyrin III ferrochelatase
- Multicopper oxidase MmcO
- Iron-dependent repressor IdeR
- Uncharacterized MFS-type transporter Rv1877
- Probable glutamine synthetase GlnA3
- Amidohydrolase-related domain-containing protein
Sequence:
MQGDPDVLRLLNEQLTSELTAINQYFLHSKMQDNWGFTELAAHTRAESFDEMRHAEEITDRILLLDGLPNYQRIGSLRIGQTLREQFEADLAIEYDVLNRLKPGIVMCREKQDTTSAVLLEKIVADEEEHIDYLETQLELMDKLGEELYSAQCVSRPPT
Protein: Collagen alpha-1(XX) chain (Q9P218)
Organism: Homo sapiens (Human)
Function: Probable collagen protein.
Subcellular location: Secreted, extracellular space {ECO:0000305}.
Interaction partners:
- Solute carrier family 35 member C2
Sequence:
MSSGDPAHLGLCLWLWLGATLGREQVQASGLLRLAVLPEDRLQMKWRESEGSGLGYLVQVKPMAGDSEQEVILTTKTPKATVGGLSPSKGYTLQIFELTGSGRFLLARREFVIEDLKSSSLDRSSQRPLGSGAPEPTPSHTGSPDPEQASEPQVAFTPSQDPRTPAGPQFRCLPPVPADMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLICQRLQGGSPRQGPAAAPALDTLPAPTSLVLSQVTSSSIRLSWTPAPRHPLKYLIVWRASRGGTPREVVVEGPAASTELHNLASRTEYLVSVFPIYEGGVGEGLRGLVTTAPLPPPRALTLAAVTPRTVHLTWQPSAGATHYLVRCSPASPKGEEEEREVQVGRPEVLLDGLEPGRDYEVSVQSLRGPEGSEARGIRARTPTLAPPRHLGFSDVSHDAARVFWEGAPRPVRLVRVTYVSSEGGHSGQTEAPGNATSATLGPLSSSTTYTVRVTCLYPGGGSSTLTGRVTTKKAPSPSQLSMTELPGDAVQLAWVAAAPSGVLVYQITWTPLGEGKAHEISVPGNLGTAVLPGLGRHTEYDVTILAYYRDGARSDPVSLRYTPSTVSRSPPSNLALASETPDSLQVSWTPPLGRVLHYWLTYAPASGLGPEKSVSVPGARSHVTLPDLQAATKYRVLVSAIYAAGRSEAVSATGQTACPALRPDGSLPGFDLMVAFSLVEKAYASIRGVAMEPSAFGGTPTFTLFKDAQLTRRVSDVYPAPLPPEHTIVFLVRLLPETPREAFALWQMTAEDFQPLLGVLLDAGKKSLTYFHRDPRAALQEATFDPQEVRKIFFGSFHKVHVAVGRSKVRLYVDCRKVAERPLGEMGSPPAAGFVTLGRLAKARGPRSSSAAFQLQMLQIVCSDTWADEDRCCELPASRDGETCPAFVSACSCSSETPGPPGPQGPPGLPGRNGTPGEQGFPGPRGPPGVKGEKGDHGLPGLQGHPGHQGIPGRVGLQGPKGMRGLEGTAGLPGPPGPRGFQGMAGARGTSGERGPPGTVGPTGLPGPKGERGEKGEPQSLATLYQLVSQASHVSKFDSFHENTRPPMPILEQKLEPGTEPLGSPGTRSKALVPGEWGRGGRHLEGRGEPGAVGQMGSPGQQGASTQGLWE
Protein: Heme/steroid binding domain protein, putative (Q4WRF3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
Sequence:
MSELRQRQVPAQSPSTSDKPTKSASPRRSDDGGISVADIIRVLLTLVVASCGLSYYMTGESVLWGYRPWFTRWPVLVQYIKGPVYLTPDQLALYNGTDPSLPIYVAVNGTIFDVSANRLVYGPGGSYNFFAGRDATRAFVTGCFQEDLTHDLTGVEEMFIPLENEEEDKKLSSGERKIRREQDRRVALGKVRKQVAHWENFFRNHKKYFAVGKVVGLENLPKEKRELCKAARQQRPKKREVVG
Protein: Bowman-Birk type proteinase inhibitor B7 (HOSPI-B7) (C0HLT3)
Organism: Hyacinthus orientalis (Common hyacinth)
Function: Serine protease inhibitor. Inhibits trypsin (Ki = 65 nM) and weakly inhibits chymotrypsin (Ki = 295 nM). Does not inhibit bacterial subtilisin.
Interaction partners:
Sequence:
GEGACCNNCDFICGRAGFSRCRCLDLVTKCHPSCSNCEMTETPYWPCRYQCLDMDPDDCATP
Protein: BNIP3, isoform A (RE48077p) (Q9VPD6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- Autophagy-related 8a, isoform A
- BG1
- GTP-binding protein Rheb homolog
- Autophagy-related 8b, isoform A
- Serine/threonine-protein kinase Pink1, mitochondrial
- Autophagy protein 5
- Ubiquitin-like modifier-activating enzyme ATG7
- RE45833p
- Uncharacterized protein, isoform B
- Autophagy protein 12-like
Sequence:
MSTTPKSSEDLLGESWIELSTTAAMAGIKSPDRITPLPFNNGEEYLRLLREAQRESNQSSRVVSLASSRRDTPRDSPKSPPNSPQSELCPDDELRNVYINYWTKGGDKQNAGNEDWLKNWNQPPSSWNIEDSSRDAGDEGEKKKTNTGYSIRLKRLGSNSLFSREILYSLLVTNVLSLLLGAGFGLWLSKRGILLTRVVID