wanglab/gogpt-training-data huggingface dataset:
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (A0A8I6AM23)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK
Protein: Pleckstrin homology domain containing, family A member 5 (A0A0N4SVR9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
GSSETGLAGSKPFSSVKYKSEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHLEDAEPQNADIGRKLKRSEMLYTPEPNGMASEEVTEKERQKEQVHADGSCSPQEETAMTEHQMEGPPEEAESLHEEEETLASCEPAPEIPRENQTTVRSLSPSPDSSTAADPPTPPQLREGSHFMCV
Protein: Neuropeptide S (P0C0P6)
Organism: Homo sapiens (Human)
Function: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
Subcellular location: Secreted.
Interaction partners:
- Neuropeptide S receptor
- Hypocretin neuropeptide precursor
- Relaxin-3
- Neuromedin-U
- Pro-opiomelanocortin
- Corticoliberin
- Oxytocin-neurophysin 1
- Neuromedin-S
- Cholecystokinin
- Neuromedin-U receptor 2
Sequence:
MISSVKLNLILVLSLSTMHVFWCYPVPSSKVSGKSDYFLILLNSCPTRLDRSKELAFLKPILEKMFVKRSFRNGVGTGMKKTSFQRAKS
Protein: Protein Tob1 (Transducer of erbB-2 1) (P50616)
Organism: Homo sapiens (Human)
Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.
Interaction partners:
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 8
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 2
- 182 kDa tankyrase-1-binding protein
Sequence:
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
Protein: Protein FAM241B (Q96D05)
Organism: Homo sapiens (Human)
Function: May play a role in lysosome homeostasis.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q8N8J7}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVRILANGEIVQDDDPRVRTTTQPPRGSIPRQSFFNRGHGAPPGGPGPRQQQAGARLGAAQSPFNDLNRQLVNMGFPQWHLGNHAVEPVTSILLLFLLMMLGVRGLLLVGLVYLVSHLSQR
Protein: 2-methyleneglutarate mutase (EC 5.4.99.4) (Alpha-methyleneglutarate mutase) (Q59268)
Organism: Eubacterium barkeri (Clostridium barkeri)
Function: Involved in the fermentation of nicotinate to ammonia, propionate, acetate and carbon dioxide.
Interaction partners:
- Putative repair enzyme for 2-methyleneglutarate mutase
- 3-methylitaconate isomerase
- L-serine dehydratase
- Pyruvate:ferredoxin oxidoreductase
- Pyruvate:ferredoxin oxidoreductase
- 6-hydroxynicotinate reductase
- 2,3-dimethylmalate lyase
- Amino acid synthesis
- Enamidase
- Acyl-CoA synthetase
Sequence:
MQEKTKRIIKEDIEAVRAYSDCFDVEMPDLDENGEVIGLPAPYPREVAGTVRSGYRIYDLAKKAKERGWPIQNPILGRNTAEETYGESQEMYAYADKFDETLFHFVHAEATRHIDPLKGRELINQSRGKGGITPIGEREFIAMGGGSKHPVRINATGDTPHLSIINALIAGFDGTDIGPVIHVHFGGRGIHDYKTKVVNGYKAIQICAENNIFVQLDSHKHLNNIGGTDGMALAMCLLSEGLAVHAGLPWELSAIQMNVAGINIYADLAVMRAFRKACHSKSIIAVPETFQNPPGNLVAEAAHFSRMAVTAKLGGADFYRPKAAESVGIPTGDSMGQAIWGTEDVFGHVVNPDIQSPVIDAREAEIIDEALAVLEATLHLEGLTLEAMTDDFWKQWSDEALIDLIVAAGKAGVLDSQRAAGWDLKRHVVVNRDKDGITRYVKGYTPLGVDASRCAQSDEDVEVHVEKAPTRPEKIVLATVGADAHVNGINVIREAFQDAGYDVVYLRGMNLPESVAEVAAEVGADAVGVSNLLGLGMELFPRVSKRLEELGLRDKMVVCAGGRIAEKEEEHRQFEEKIQKEGSAFMGMDGFFGPGSSPEDCVKIIGDMINAKKA
Protein: Small ribosomal subunit protein uS8my (40S ribosomal protein S15a-5) (Q9M0E0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000303|PubMed:36423343}.
Interaction partners:
- Large ribosomal subunit protein eL31x
- Small ribosomal subunit protein uS15y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- 50S ribosomal protein L33
- Small ribosomal subunit protein eS25y
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein uL2x
- Large ribosomal subunit protein uL1z
- Large ribosomal subunit protein uL1x
- Large ribosomal subunit protein uL30y
Sequence:
MGRRILNDALRTIVNAERRGKASVELKPISTVMSSFLRIMKEKGYIKNFQVYDPHRVGRITVDLQGRVNDCKALTYRQDVRAKEIEKYTERTLPTRQWGYVVITTPDGILDHEEAIKRNVGGQVLGFFY
Protein: Exocyst complex component SEC3 (Protein PSL1) (P33332)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Interaction partners:
- Exocyst complex component EXO70
- Exocyst complex component EXO84
- Exocyst complex component SEC10
- Exocyst complex component SEC8
- Exocyst complex component SEC15
- Exocyst complex component SEC5
- Exocyst complex component SEC6
- GTP-binding protein RHO1
- Cell division control protein 42
- Protein SSO2
Sequence:
MRSSKSPFKRKSHSRETSHDENTSFFHKRTISGSSAHHSRNVSQGAVPSSAPPVSGGNYSHKRNVSRASNSSQTSNFLAEQYERDRKAIINCCFSRPDHKTGEPPNNYITHVRIIEDSKFPSSRPPPDSKLENKKKRLLILSAKPNNAKLIQIHKARENSDGSFQIGRTWQLTELVRVEKDLEISEGFILTMSKKYYWETNSAKERTVFIKSLITLYIQTFEGHVPELVNWDLSLFYLDERSYQRAVITNRPGSVSPIKSPTSNFTTNTTQSVGSVPFSAPTERTRRSETESVNPVSTPASVEYHAGMKSLNKAPYSSNSTLNEVNKRYELEQQQQQEEAELRRLEEQKRLQLQKENEMKRLEEERRIKQEERKRQMELEHQRQLEEEERKRQMELEAKKQMELKRQRQFEEEQRLKKERELLEIQRKQREQETAERLKKEEQEALAKKEEEEKSKRNKVDNESYTQEINGKVDNLLEDLNAVLAEETETTPTMQNGTYVPERSTARAHDQLKKPLNIAKVESLGGSDLNDSISLSDEIAGLNTSNLSGEDQDEKNDLSFEKGDEVRYSNNFEGEAPHVYHEVSIIQEEAPAVSQKLILPEENNESEALIESKEEIKTMENIDDEVLLEILTDINWSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIRPYEDKVNDECHRIIPTLSLFLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELLKTVSLDEISLNQLLECPIREKNLPWMENQLNLLLKAFQAIGSDGNEVEYNLREISGLKQRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDISHDQMIRILTTLLIFSPLILFCKEISQKSYQAIVENWNVSIQPVYMELWTKKISQLQGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDINPVFKNSFSLLTECLQTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAPPILLDTVKVMQSDREAAVIETQLVSRIFQPIVTRLSSYFVELVKAEPTVAPALTFYLENEIKSLESSNHEFLLSAVTRMYTQIKQVWSDNVEEQVLHFERISNATTNGEILPGILDLPVGLKNSEDLFQFAKRSMDIKDTDEGYESIELMNSSFRKLSIAATRSITHKEVNSSINPNLSDTAALNNDYMETISLLVNSNWLTEMLSMLNFNKDGIFDTSLQNVKKVFDVEKESYASFLLRDTMPKLTAFVYGVSNIIENTNNVNMTNPSRWAAYSRQNLENILLAYTSHEIETLVKRLHTHMVNDFGYHQENAINNVLCDKLWSCIQGQTVSLYLKLYTVIDKHYRGTNIRFTKNDIISAFEEYKNA
Protein: Transcriptional regulator, LacI family (Q9A3Y5)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- phosphoenolpyruvate--protein phosphotransferase
- phosphoenolpyruvate--protein phosphotransferase
- Glutamate synthase large chain
Sequence:
MNQPVERQRRRTTQSATIRDVAARAGVSPMTVSRVINRESTVKEETRQLVEKAIADLNYAPNPAARSLAGSAPFRIGLLYDNPSTGYLSEFLVGALDESSRTGAQIVIEKCAEPELARATLARLLKTGVDGLILPPPLCESPEVLAEIRAAGAAAVAVAPGTASADMATIRIDNEAAAFELTQHLIGLGHKRFGFIKGHPNQTVSQQRLDGFMTALKAAGIPQENIRVEQGYFTYRSGLEAAERLLAAEPRPTAIFAANDDMAAATAGVAHRLGLDVPGDVSIVGFDDTSIADNIWPPLTTVHQPIAAMARAAVDLVLEEIRRHRDGGGEPRQLMHPHTLIVRDSSGPAGV
Protein: Large ribosomal subunit protein eL31 (60S ribosomal protein L31) (P62901)
Organism: Sus scrofa (Pig)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62899}.
Interaction partners:
- Ubiquitin-like protein FUBI
- 40S ribosomal protein S30
- Small ribosomal subunit protein uS14
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS17
Sequence:
MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN
Protein: Possible transcriptional regulatory protein NadR (Probably AsnC-family) (P96394)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Glutamine-dependent NAD
- NAD-dependent protein deacylase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Probable nicotinate-nucleotide adenylyltransferase
- CinA-like protein
- Nicotinate phosphoribosyltransferase pncB1
- Nicotinate phosphoribosyltransferase pncB2
- NAD kinase
- Quinolinate synthase
- NAD-capped RNA hydrolase NudC
Sequence:
MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIPGAQRVAWMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGAEPYNADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPAFVKRVSIIGPESTGKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLEWAEIVRGQIASEEALARDADRVLICDTDPLATTVWAEFLAGGCPQELRDLARRPYDLTLLTTPDVPWDADDGRCVPGARGTFFARCEQALRAAGRSFVVITGGWEERLSVSLRAVEELVRARR
Protein: Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) (P12036)
Organism: Homo sapiens (Human)
Function: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27040688}. Cell projection, axon {ECO:0000250|UniProtKB:P19246}.
Interaction partners:
- Neurofilament light polypeptide
- Neurofilament medium polypeptide
- Alpha-internexin
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Kinesin light chain 1
- Kinesin light chain 2
- Kinesin light chain 3
- Kinesin-1 heavy chain
- Kinesin light chain 4
Sequence:
MMSFGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK
Protein: Integrin subunit alpha 2b (A0A8I6GGN2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
Sequence:
MARASCAWNTLWLLQWTPLFLGPSAAPPAWALNLDSVKFSVYTGPNGSHFGFSVDFHKDSHGSVSIVVGAPRALNANQEETGGVFLCPWKANNGTCTSLLFDLRDETRKLSLQTFQTFKTGQGLGASVLSWNDVIVACAPWQHWNVLEKYDEAEKTPVGGCFVAELQSGGRAEYSPCRSNTMSSVYSQGFSGDKRYCEAGFSLAVTQAGELVLGAPGGYFFLGLLVRVPIENIISSYRPGTLLWHVSNQRFSYDSSNPVYFHGYRGYSVAVGEFDGDLSTTEYIFGAPTWSWTLGAVEILDSYYQTLHRLHGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRVDRKLAEVGRVYLFLQPKGLQALSSPTLVLTGTQVYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQVLDSPFPTGSGFGFSLRGSVDIDDNGYPDLIVGAYGASKVAVYRAQPVVMATVQLMVQDSLNPTLKNCVLEQTKTPVSCFNVQMCVGATGHNIPQKLHLKAELQLDLQKPRQARRVLLLASRQASLTLSLDLGGRNKPICHTIKAFLRDEADFRDKLSPIVLSLNVSLPPEETGVAPAVVLHGVTHVQEQTRIILDCGEDNLCVPQLQLTATAGDSPLLIGADNVLELKVNASNDGEGAYEAELAVHLPPGAHYIRAFSNVKGFERLVCTQKKENESRLALCELGNPMKKDTRIGITMLVSVEILEEAGDSVSFQLQIRSKNSQNPNSEAVLLPVAVRAEAAVELRGNSFPASLVVAAEEVDKEQDGLDSWVSRVEHTYELHNNGPGTVNGLSLIIHLPGQSQPSDLLYILDVQPKGGLLCSTQPPPKLLKVDRRLTTPSPSSIRRIHHDRDRREASPQGSKQTEQQDPVLVSCNGSAPCTVVECELQEMVRGQRAMVTVQATLGLSILRQRPQEQFVLQSHAWFNVSSLPYSVPVVSLPSGQGLVQTHLLRALEERDIPVWWVLVGVLGGLLLLTLLVLAMWKAGFFKRNRPPLEEEEEEE
Protein: Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) (Q63495)
Organism: Rattus norvegicus (Rat)
Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19910580}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q15109}. Early endosome {ECO:0000250|UniProtKB:Q15109}. Nucleus {ECO:0000250|UniProtKB:Q62151}. Note=Nuclear translocation is enhanced by irradiation, hypoxia and reperfusion injury to brain or kidney. {ECO:0000250|UniProtKB:Q62151}.
Interaction partners:
- High mobility group protein B1
- Protein S100-B
- High mobility group protein B1
- Protein diaphanous homolog 1
- NADPH oxidase 4
- NADPH oxidase 2
- GTPase NRas
- NADPH oxidase 1
- GTPase HRas
- High mobility group protein B1-like
Sequence:
MPTGTVARAWVLVLALWGAVAGGQNITARIGEPLMLSCKGAPKKPTQKLEWKLNTGRTEAWKVLSPQGDPWDSVARILPNGSLLLPAIGIVDEGTFRCRATNRLGKEVKSNYRVRVYQIPGKPEIVNPASELTANVPNKVGTCVSEGSYPAGTLSWHLDGKPLIPDGKGTVVKEETRRHPETGLFTLRSELTVTPAQGGTTPTYSCSFSLGLPRRRPLNTAPIQPRVREPLPPEGIQLLVEPEGGTVAPGGTVTLTCAISAQPPPQIHWIKDGTPLPLAPSPVLLLPEVGHEDEGIYSCVATHPSHGPQESPPVNIRVTETGDEGQAAGSVDGSGLGTLALALGILGGLGIAALLIGAILWRKRQPRLEERKAPESQEDEEERAELNQSEEAEMPENGAGGP
Protein: Aladin (Adracalin) (P58742)
Organism: Mus musculus (Mouse)
Function: Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9NRG9}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9NRG9}. Nucleus envelope {ECO:0000250|UniProtKB:Q9NRG9}. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate. The localization to the spindle is microtubule-mediated. {ECO:0000250|UniProtKB:Q9NRG9}.
Interaction partners:
- E3 SUMO-protein ligase RanBP2
- Nuclear pore complex protein Nup88
- Nuclear pore complex protein Nup214
- Nuclear pore complex protein Nup155
- Nucleoporin NDC1
- Nucleoporin 205
- Nucleoporin SEH1
- Nuclear pore complex protein Nup93
- Nucleoporin NUP188
- Nuclear pore complex protein Nup107
Sequence:
MCSLGLFPPPPPRGQVTLYEHNNELVTGNSYESPPPDFRGQWINLPVLHLTKDPLKAPGRLDHGTRTAFIHHREQVWKRCINVWHDVGLFGVLNEIANSEEEVFEWVKTACSWALALCGRASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPNGGWLLSASPVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEAQMWTCEAWPTLSGRCQTGCWSPDGNRLLFTVLGEALIYSLSFPERCGTGKGHVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGNPQVQDGNPVILLFRTRNSPVFELLPCGIIQGEPGAQAQLITFHPSFNKGALLSVCWSTGRITHIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHEVPLFTETSPTSAPWDPLPGQSSAQPHSPHSHL
Protein: F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) (Q9NXK8)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
Sequence:
MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM
Protein: Granulito (Uncharacterized protein C8orf88 homolog) (B3DKF4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Dead end protein 1
Sequence:
MTEAEDAVNEAWSFEHIKMDVSKRIVRHLEPARPLRRFRLNQVPQSYAETRPIEKPDNIITVENFYEILHLKSTETQQKKKVERICYTRDFLVKMANSPMSKEKPEFLPDHPVVLKNGRPSDLPRYFSTSYNNNNYKHLSD
Protein: RE37929p (Q8IGS2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFLRRCTLLLLICLIASDAASAARKTKRPVKPVKQTNPRTNVTPSPPAVASSGSSTPASTSSTTTTEGSGDQEVATVGSAALAGGGELPKPLVTPIEAQPEAKTDKAPALEEECDPDMIGFEIITGYVLSAPSKMLDTLPGTLMLTDCLEACQSNESCSAVNYETGLCVLFKTTADKLPGSLSRSQFPVFTIYAQKSCLGVRPCSKAWCIDRVQGYRLPEHVKSSQTVLSRRDCLELCLGETEFTCRSANYYRHSGLCELSDMDRITLSAGGSVEPYDGADYLENNCAEEPSKLCEFKRISGKILKAVDSVYQDINTIDECRDLCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLTDVMDPYLDVPEAATYELSACYNVSIECRSGEMITKIRTSKLFDGKVYAKGAPKSCAVNVNNSLEFDFRMGYNDLECNVRQSAYGRYMNDIVIQHHDMIVTSSDLGLAVSCQYDLTNKTVLNDVDLGVTGEIESSLSEEITIDSPNVIMKITSRDGSDMKRMAEVGDPLALRFEIVEPNSPYEIFVRELVAMDGSDSAEITLIDANGCPTDQYIMGTIQKLAQNRKVLLSQFDAFKFPSSEVVQFRALVTPCIPRCEPVICDSEDGASGELKSLVSYGRKKRSVLNGTDGAEFLISTRHRRDVGPVDDNILLMQSIQITDKFGFQPEDGTTTHGNDSGPHEKAYAGVAQDKLTCLNGYGLIMAGALFLLAQLSIFGIWKTVQRRTSKERYLYQHEPTPTITYGAPTMLYGPPPNSSAGSSASGTSYGGSAKDTLSKLYDSGINGRYGQQF
Protein: RPGRIP1 like (H3BV03)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTKGDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAPRPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQSLALSPGLGCSSAISAHCNFRLPGSSDFPASASQVDGITGACHHTQPSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA
Protein: LIM domain-containing protein B (Paxillin-A) (Q54NW4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Regulates and controls rearrangements of the actin cytoskeleton. Required for tip formation, morphogenesis, cell adhesion and motility, chemotaxis and aggregates formation. May function downstream of paxB.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:10749929}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10749929}.
Interaction partners:
- Ras suppressor protein 1
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
Sequence:
MANKNVLSEMDDLMAELGLVETTATPTSDQIKQPQQETAPTYLTYKDPNVSTGPGGDFRNLNDNNGGISRGPGLMSTGPGLVSTGPGLMSTGPGLMSKGPGLPNNSINNNISNNNGGGISSGPGLSFGVSSGVSSGVSSGVSSGVSSGVTLVAQNHLARQPSPPLNSQQQQQQQLPTYLDGVGTLQPISLAATTPDGRVVKANGPICGACGDMIIGVCTNALGRSYHPEHFVCTYCKLPFSGSFIEHEEKLYCENDYLELFSPRCFACIKPIEDTCINALGNRYHPECFSCSGCGDKLRGKPYKEEDGEVYCNTCKIARQKRLAAKSEICSKCKLPITGEYIILQGQPVHSEHYRCEECGCEFNVGKTCHEYEGRLYCYEDYQKQILNICGACSKPIVGRSITALGKVWHPEHFTCTTCQVPFAGSAFREHAGKPYCESHYHQFFGRQCFKCSKPVVDTGVEVFGKIYHREHFTCTGCECVLGKEIMEWDGKPLCFKCFDALPKEVRKRIKEKKAGDKKAEAYREKLAKKEAKELKKERERAAKEKEKESKAK