wanglab/gogpt-training-data huggingface dataset:
Protein: Cicadin (P83282)
Organism: Cicada flammata
Function: Possesses antifungal activity against B.cinerea, M.arachidicola, F.oxysporum, R.solani and C.comatus.
Interaction partners:
Sequence:
NEYHGFVDKANNENKRKKQQGRDDFVVKPNNFANRRRKDDYNENYYDDVDAADVV
Protein: Zgc:136228 (Q1ED33)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYKNSYSQATFGLEAKKIHKAKKGKSCGYYMRIVFFFSSLIQSLIIASLVLFLVYGQPEKTAEEKRLEDLQQAYDTLSKDHTKLRKEKADLATALKTKSGEKDAADKEITKLKTDLNISIAGSKNWQRLNSQCEANAKLKLSSTRNTPLMCPPANPNQSGEVKTLNTLLDQQKALYGILKSNFSQTVEYLKSDLDHAVKDKNEHHSQVIKLRQENKDLKSQLDVYTKKCKEDFADSLQGIQTVTTAFLSKIDNFFTNSVTFHLTCPKQEEQMDRIRSNCSSLSRQVEDKFQSYLNNVGAKVSNIQKQSSWLEIQNEKLTSELDKCKTEAEKEASDSSKKLQDAQTTCDKQLEQLLKEQTRLRNAKDLVDTELSVKEATIISLQKGCTPQAKSSGFQPLGSVGQYPSTSG
Protein: At2g37950 (RING/FYVE/PHD zinc finger superfamily protein) (Q5XEN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Basic leucine zipper 9
- Cysteine rich peptide
- Cysteine rich peptide
Sequence:
MTTDIDLEQGGAFGYHRRSLDGSDVSVYYSDGEDVMSCYSYFYSTTGGSYEYEGDQSRKVSSVMSPSSSEIDDDDATAPPEKDCRICHLGVETSGGGAIELGCSCKDDLAVAHRQCAETWFKIKGDKTCEICQSVARNVGGANEMVGSTMEERELRNGEETAAGEGGGATVVENRWQPQRVVNLVLACMVFGFFISWIFHFHVSSSS
Protein: NAD(P)H-quinone oxidoreductase subunit I, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit I) (NDH subunit I) (NADH-plastoquinone oxidoreductase subunit I) (P56755)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01351}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01351}.
Interaction partners:
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- Photosystem I iron-sulfur center
Sequence:
MLPMITGFMNYGQQTLRAARYIGQGFMITLSHTNRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETNIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYEFSTYDRHELNYNQIALGRLPMSVIDDYTIRTIWNSPQTKNGVNPLI
Protein: NACHT domain- and WD repeat-containing protein 1 (Q149M9)
Organism: Homo sapiens (Human)
Function: May play a role in the control of androgen receptor (AR) protein steady-state levels.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24681825}.
Interaction partners:
Sequence:
MQRGKPCRALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDPLKNFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV
Protein: ADAM metalloprotease (Meltrin, isoform C (EC 3.4.24.-)) (Q6QU65)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Furin-like protease 1, isoforms 1/1-X/2
- Furin-like protease 2
Sequence:
MLHLHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVPLHADPKLNVKRDGTIRRFASFLKKEEKPPLKEKTYIDRERLRTLEISAPMPVPAAPQAESSNSDSETTPREEETQNLVKRAQSMRSPTKKAPLQSFGSMRSPPGLPRPKSGQVNSNGASRPKSPPPRPPPVVVKKTNSISSSGYQRPVSTAQRSVENTYDDCEFVENEVRASNDDIYSVIDEIPPAAQTLKRSDLVANRASNGSDMGLLNEIVNELEKINGDSIYSGKPVAAAASAAQPTPADPPKSPQRPAPPKPASSVLEEKAANASASTYHRPPPANAPVARVKPTVADKSQAQAQAQPSMSSFKPAAGGNVGQSQPAPVVQLAKRSSSGSMSGVTNYARPKSFMKSTTKTLPNGTAGASTTAPSATIQKPKPLSAKPSFSGGGAGGVLGKRANGGAAPTPPTVKAATLAAAPKSNIASLTQRFEQSK
Protein: YscF putative type III secretion protein (Q663I4)
Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
Subcellular location: Cell surface {ECO:0000256|ARBA:ARBA00004241}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSNFSGFTKGTDIADLDAVAQTLKKPADDANKAVNDSIAALKDKPDNPALLADLQHSINKWSVIYNINSTIVRSMKDLMQGILQKFP
Protein: Geranyl diphosphate 2-C-methyltransferase (GPP methyltransferase) (EC 2.1.1.255) (A4FG18)
Organism: Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Function: Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP).
Interaction partners:
- 2-methylisoborneol synthase
- Cyclic nucleotide-binding domain
- Hydroxylase
- IclR-type transcriptional regulator
Sequence:
MTKSIHENGTAASVYQGSIAEYWNQEANPVNLELGEVDGYFHHHYGIGEPDWSVVEGDAATSHERTTRELHRLETWQAEFLLDHLGGVEPEHRIMDAGCGRGGSSFMAHERFGCSVEGVSLSRKQVDFANAQARERGVADKVAFHQLNMLDTGFDTASMRAIWNNESTMYVDLHDLFAEHSRLLARGGRYVTITGCYNDVYGLPSRAVSTINAHYICDIHPRSGYFRAMAANRLVPCAVVDLTEATVPYWRLRAKSPLATGIEETFIEAYTSGSFQYLLIAADRV
Protein: Autoinducer-2 kinase (AI-2 kinase) (EC 2.7.1.189) (P77432)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. Required for the regulation of the lsr operon and many other genes.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02053}.
Interaction partners:
- Transcriptional regulator LsrR
- Autoinducer 2-binding protein LsrB
- (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (Autoinducer 2-degrading protein LsrG) (AI-2-degrading protein LsrG) (Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase) (Phospho-AI-2 isomerase)
- 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
- Autoinducer 2 import system permease protein LsrD
- Autoinducer 2 import system permease protein LsrC
- Phosphocarrier protein HPr
- Autoinducer 2 import ATP-binding protein LsrA
- S-ribosylhomocysteine lyase
- AI-2 transport protein TqsA
Sequence:
MARLFTLSESKYYLMALDAGTGSIRAVIFDLEGNQIAVGQAEWRHLAVPDVPGSMEFDLNKNWQLACECMRQALHNAGIAPEYIAAVSACSMREGIVLYNNEGAPIWACANVDARAAREVSELKELHNNTFENEVYRATGQTLALSAIPRLLWLAHHRSDIYRQASTITMISDWLAYMLSGELAVDPSNAGTTGLLDLTTRDWKPALLDMAGLRADILSPVKETGTLLGVVSSQAAELCGLKAGTPVVVGGGDVQLGCLGLGVVRPAQTAVLGGTFWQQVVNLAAPVTDPEMNVRVNPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLIAERLGIDTYTLLEEMASRVPPGSWGVMPIFSDRMRFKTWYHAAPSFINLSIDPDKCNKATLFRALEENAAIVSACNLQQIADFSNIHPSSLVFAGGGSKGKLWSQILADVSGLPVNIPVVKEATALGCAIAAGVGAGIFSSMAETGERLVRWERTHTPDPEKHELYQDSRDKWQAVYQDQLGLVDHGLTTSLWKAPGL
Protein: F-box domain-containing protein (O16525)
Organism: Caenorhabditis elegans
Interaction partners:
- Skp1-related protein
Sequence:
MSDSPRSDEEDLSEGSDSSVSLHQIDPKIQCIVTDPRAVRILILHQHLQGIPVFNAYKAMNKVFGDHFMEYRHFEYWYMGLANGSLTVDSYDRFHTSERKEFTDFSTYFQAMILDKLNPIDRFAARAVCRGFKSMIDYQHSNLKTMTMYLEEKSVGLKTNGGYVTYELEDEDCQVNYKKRKMIVKDKKPLEVAMKDVSRLLKIRGLDMDYFAIIMTEIMEEEFVSFDAINDVLKSIGILSAKSVLLDWFHTFEITVLLKYFKPGILEDLTIKCLESDEEFTGNLVYLEQWKKAKNLKLSKVPNFPIIVEHLDNFKSLNFDFHGEPFSRDDIMKLRDEVLLKSTKFEYFSCKNVKFNTKMFVKVFDARSTLFCSSGSIVYESSNGIFDIAYHPNGFNIKKKIDSQV
Protein: G-protein coupled receptor Mth (Protein methuselah) (O97148)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up-regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12367510}; Multi-pass membrane protein {ECO:0000269|PubMed:12367510}. Note=Plasma membrane of presynaptic terminals and innervating axons.
Interaction partners:
- Protein I'm not dead yet
Sequence:
MKTLLVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQESIRGEGEEVNNSEEEISLENTTTRNVLL
Protein: Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (Q9Y948)
Organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Function: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00114}.
Interaction partners:
- ATP-dependent 6-phosphofructokinase
- Phospho-sugar mutase
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase
- Probable fructose-bisphosphate aldolase class 1
- 2-oxoacid oxidoreductase
- Fructose-1,6-bisphosphate aldolase/phosphatase
- 2-oxoacid oxidoreductase
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
- Phospho-sugar mutase
Sequence:
MPSARDILQQGLDRLGSPEDLASRIDSTLLSPRATEEDVRNLVREASDYGFRCAVLTPVYTVKISGLAEKLGVKLCSVIGFPLGQAPLEVKLVEAQTVLEAGATELDVVPHLSLGPEAVYREVSGIVKLAKSYGAVVKVILEAPLWDDKTLSLLVDSSRRAGADIVKTSTGVYTKGGDPVTVFRLASLAKPLGMGVKASGGIRSGIDAVLAVGAGADIIGTSSAVKVLESFKSLV
Protein: Urease accessory protein F (AtUREF) (Q9XHZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.
Interaction partners:
- Urease accessory protein D
- Urease accessory protein G
- Urease
- F-box protein At1g70590
- Probable diphthine methyl ester synthase
- Pentatricopeptide repeat
- At4g12840
- MIF4G domain-containing protein
- At4g27620
- Uncharacterized protein AT4g35690
Sequence:
MEEDERRDIVMSRASSCMQWSQWQLLDSILPTGGFAHSFGLEAAIQTRLVSSPEDLETHIIHVLDNTASLLLPFVYSALKSPDIETWHKLDGILNATLTNQVSSKASMSQGSALFRIAASVFTEVPNLKMIRDASLGSKNVCFHHAPIFGLVCGLLGMDSETSQRAYLFVTLRDVLSAATRLNIVGPMGASVMQHRIAIVTETVLEKWMNREAGEACQTSPLLDVVQGCHGYLFSRLFCS
Protein: Cell wall mannoprotein PIR1-like C-terminal domain-containing protein (G8BAM6)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- SWR1-complex protein 3
- chitin deacetylase
- Tubulin beta chain
- Protein kinase domain-containing protein
- Glycogen synthase kinase 1
- Tubulin alpha chain
Sequence:
MKYTTIATSAAFLTTALAATVPSAPWTTLTPSASIPTDATTDYTSSFGIQIETVEAASALSTDSATDLSSKLETASATLGKRAVVSALSDGQPNVRSGSYSILPSSSSSASKSSVAPVAQITDGQIQHQTTAAAASVVNQITDGQIQHQTTQASVVNQIGDGQIQHQTTQASVVNQIGDGQIQHQTTQASVVNQIGDGQIQHQTSAASVINQIGDGQIQHQTTAAAASAVNQITDGQIQHQTTAEPTASAAAQISDGQIQHKNSTVAAESRAAATTLSDGQPQESGVSSSNDEDSSSSIPKACSSSNNLVMKLEDGVLTDSKGRIGAIVANRQFQFDGPPPQAGSIFAAGWSISKDGYLTLGDSKVFYQCLSGDFYNLYDENVAAQCNAVKLKIIDFVDC
Protein: TANK binding kinase 1 (A0A494C148)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGFGSLTMDGGLRNVDCL
Protein: Protein DEPP1 (Fat-specific-expressed gene protein) (Protein DEPP) (Q8K2F3)
Organism: Mus musculus (Mouse)
Function: Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NTK1}. Peroxisome {ECO:0000250|UniProtKB:Q9NTK1}. Mitochondrion {ECO:0000250|UniProtKB:Q9NTK1}. Note=May localize to aggresomes. {ECO:0000250|UniProtKB:Q9NTK1}.
Interaction partners:
Sequence:
MRSRLLLPVPHLPTIREMSEELSHGAAGQEPPASPSLDDYVRCICQLAQPTSVLDKVTAQSRPNRPSRPAWTREKRRQAESPGDSSLCVSSLQPTLPSPGTDNPLDWLFGKSQGEQADGRGRPNRTGSSDPWDVPRQMGKDTGRLCEARVPEHSLGRKPGPRHQTSDLKSWTSRKSCRALASVSSSRPSSILGTLYLHLPVIHEL
Protein: ABC transporter D family member 2, chloroplastic (ABC transporter ABCD.2) (AtABCD2) (EC 7.-.-.-) (Q6NLC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Plastid, chloroplast {ECO:0000269|PubMed:18431481}.
Interaction partners:
- Peroxisome biogenesis protein 19-1
- Peroxisome biogenesis protein 19-2
- Peroxisome biogenesis protein 12
- Peroxisomal membrane protein PEX14
- Peroxisome biogenesis protein 16
- ABC transporter A family member 2
- ABC transporter A family member 7
- Peroxisome biogenesis protein 3-1
- Peroxisome biogenesis protein 3-2
- ABC transporter A family member 4
Sequence:
MILMITAPVCPPHLLLRHSSLLRHESSIGNFHRKKNPRFRTVSCSSLLPQPSVRPDKASELKTLWKKFYKVASPYWFSEDKDQARLRLAAVFALTLATTGISVGFNFLGRDFYNSLANKDQEQFTKQLFYYLCAFAGGIPFFVLRDYTKETLSLRWRSWMTKYYLQRYLKDQTFYKIQSQSIIDNPDQRLVDDLSSFTGTALSFSLTLVNATIDLISFSNILFTIYPPLFLVLLLYSFGGTAISVFLGKGLVNLNFLQEKKEADFRYSLVRVRENAESIAFYGGEQNEMQLLLQRFRSAFDNLTELLIASRNLEFFTDGYRYLIQILPVAVVAPMYFSGKIEFGVINQSVSAFNHILGDFSLVVYQFQAISSFSAVIDRLGEFDDLLDNNIFRDPSDTVDEIELTYQSEMNSSLLDTNGSIKSQPNQKRLEIEELTLQTPTNGTTLVHNLSADVYDKDHLLIMGPSGSGKTSLLRAMAGLWRSGKGKITFYLDPEVDFTQEKSDTQENSGKRGDVLFLPQRPYMVLGSLRQQLLYPTWSATVEETTPGGSNIDGSPPLLIREDGNEKPTTDDLMRTLEKVCLGHIADRFGGLDSIHEWSSVLSLGEQQRLAFARLLLSQPKLALLDESTSALDEANEAFLYQQIQSAGITYISIGHRRTLTKFHNKILQISTADPKSNERNWRIEDVDAQDSLYGRLNQKEVPSES
Protein: Starvin, isoform F (M9PCD9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKPTVMAANQAQSNPATAAGNNVSPGGPGVNIPVNREYVSGGYGSPQQSAQFHTPQNAYGSPRQQQQHFQQHQQVPPNQQQQHFQQPTFGFEPNMDMDNMFPRSHLGRMHDPFAGFGDSHFGFPRFSTMGRRGRMAGGANTHMDHDDDFFNRLPSEFRQYIPDGFGGRRGTGAAPAPGQVPQQQQPQPQPQYTQQQPQTHFQFGVPPQQQPVYAGPTQQQVPQTPSKRLCDAAIQTEDPAGRSEVDCAPPTNLNQHGLRNTVDMGVKSVAEQDQGLRSHSAPPPEQQQQNLQYHQQQQQHQQPGVHSQPFGTQTSPPVQGQQFKTYYAPHQQTHPQQKQQTPPPAPQTPGGTYVRTIPIFVEGRSEPIINAHKEIPNQNAPPSAQAQAQAQAYAQAQPQAHAAPQQHNRPTPLNTQAQPEQQVPVEGAAGLPPQTPHTLNSINKIQDIQRDVLELMGKVEQFKGTREEKEYAYLDEMLTRNLLKLDTIDTNGKDSIRLARKEAIKCIQASINVLEAKAEENARAASGAAPAPSATAPAVDTGAVAASEAAGQNAEPVTPQPQDATKMQEPIPLPAPPNAAAVEGAAASEATAAEATQSAVQSETTTTTSE
Protein: DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (RNA polymerase III subunit C17) (P47076)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation.
Subcellular location: Nucleus {ECO:0000269|PubMed:12482973, ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase III subunit RPC7
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase III subunit RPC2
Sequence:
MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKGKQNRPYNHPELQGITRNVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEKLQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA
Protein: SNW/SKI-interacting protein A (OsSKIPa) (Q6K8D9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Acts as positive regulator of drought and salt tolerance. Acts as positive regulator of cell viability.
Subcellular location: Nucleus {ECO:0000269|PubMed:19339499}.
Interaction partners:
- Os02g0602500 protein
- Peptidyl-prolyl cis-trans isomerase
- Zinc finger CCCH domain-containing protein 40
- Zinc finger CCCH domain-containing protein 49
- Os03g0387000 protein
- Os05g0289400 protein
- Os04g0348300 protein
- Os06g0523900 protein
- Crooked neck protein, putative, expressed
- Os01g0582400 protein
Sequence:
MASLKELLPTPKAAASTFYDHSSDPWFKERYGGESAQSDAAAAAAKPSGPAKPVPPYGKRGGFVPRRPEDFGDGGAFPEIHVAQYPLGMGRRDEKGGSKILALTVDAKGSVAFDAVVKQGENASKIVYSKHSDLVPKIATADSEATADDEEYQKQIEETTERTKAALEKVVNVRLSAAQPKNVPTHDSESKFIKYKPSQQSAAFNSGAKERIIRMSEMAQDPLEPPKFKHKRVPRASGSPPVPVMHSPPRPVTVKDQQDWKIPPCISNWKNPKGYTIPLDKRLAADGRGLQEVQINDNFAKLSEALYVAEQKAREAVQMRSKVQRELQLKEKERKEQELRALAQKARMERTGAPPAPTGVPAGGGRGAVDDREEDMDLEQPREQRRESREEREARIERDRIREERRRERERERRLEARDAAMGKKSKLTRDRDRDVSEKIALGMASTGGAKGGEVMYDQRLFNQDKGMDSGFATDDQYNIYSKGLFTAQPTLSTLYRPKKDGDSDVYGDADEQLEKVMKTDRFKPDKGFSGASERSGKRDRPVEFDKQEENDPFGLDQFLTEVKKGKKAVEKIGSGGAMRASGGSSMRDDYEGGGSGRSRINFERGR
Protein: Cystatin-A1 (Q65YR8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Intracellular thiol proteinase inhibitor. Inhibits papain, but not cathepsin B.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15255188}.
Interaction partners:
- 14-3-3-like protein
Sequence:
MTLGGLKPEVHAANDEIRQVVAKVADELKSKLNTTEVEPVSYKTQLVAGTNYFIKVKTPAGFAHARVYKDLQQNHSVHSVKADGITEESEIVYF
Protein: Actin-related protein 10 (Actin-related protein 11) (hARP11) (Q9NZ32)
Organism: Homo sapiens (Human)
Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:I3LHK5}.
Interaction partners:
- Dynactin subunit 2
- Dynactin subunit 1
- Dynactin subunit 5
- Dynactin subunit 6
- Dynactin subunit 4
- Alpha-centractin
- Dynactin subunit 3
- Beta-centractin
- F-actin-capping protein subunit alpha-1
- Actin, cytoplasmic 1
Sequence:
MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMPKPVRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTSVAKEQSLPSVMGSVPEGVLEDIKARTCFVSDLKRGLKIQAAKFNIDGNNERPSPPPNVDYPLDGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKALGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK
Protein: ATP synthase subunit 9, mitochondrial (Q304C3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion membrane {ECO:0000256|RuleBase:RU004221}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004221}.
Interaction partners:
- ATP synthase subunit a.
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit a-2
- ATP synthase subunit a-1
- ATP synthase subunit alpha
- ATP synthase subunit O, mitochondrial
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit epsilon, mitochondrial
- ATPase subunit 4.
- ATP synthase subunit delta', mitochondrial
Sequence:
MTKREYNSQPEMLEGAKSIGAGAATIASAGAAIGIGNVFSSLIHSVARNPSLAKQSFGYAILGFALTEAIALFAPMMAFLILFVF
Protein: Ig mu chain C region membrane-bound form (P04221)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Immunoglobulin J chain
- B-cell antigen receptor complex-associated protein beta chain
- Immunoglobulin lambda like polypeptide 1
- Immunoglobulin heavy constant epsilon
Sequence:
VSLSSPTLYPLVSCEGALTDGNLVAMGCLARDFLPSSVTFSWSFKNNSEISSRTVRTFPVVKRGDKYMATSQVLVPSKDVLQGTEEYLVCKVQHSNSNRDLRVSFPVDSELPPNVSVFIPPRDSFSGSGTRKSRLICQATGFSPKQISVSWLRDGQKVESGVLTKPVEAETKGAGPATFSISSMLTITESDWLSQSLYTCRVDHRGIFFDKNVSMSSECSTTPSPGIQVFPIAPSFADTFLSKSARLICLVTDLTTYGSLNISWASHNGKALDTHMNITESHPNATFSAMGEASVCAEDWESGEQFTCTVTHADLPFPLKHTISKSREVAKHPPAVYVLPPAREQLVLRESATVTCLVKGFSPADVFVQWQQRGQPLSSDKYVTSAPAPEPQAPGLYFTHSTLTVTEEDWNSGETFTCVVGHEALPHMVTERTVDKSTEGEVGAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK
Protein: GrpE protein homolog 1, mitochondrial (Mt-GrpE#1) (P97576)
Organism: Rattus norvegicus (Rat)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial disaggregase
- Mitochondrial import inner membrane translocase subunit TIM16
- DnaJ heat shock protein family
- 10 kDa heat shock protein, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim17-A
- 10 kDa heat shock protein, mitochondrial
- Large ribosomal subunit protein uL30m
Sequence:
MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLEEDLGHCEPKTDPSSADKTLLEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA