wanglab/gogpt-training-data huggingface dataset:
Protein: Anaphase-promoting complex subunit 4 (20S cyclosome/APC complex protein apc4) (Cell untimely torn protein 20) (O42839)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
Interaction partners:
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 13
- Mitotic spindle checkpoint component mad3
- Anaphase-promoting complex subunit 14
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 15
- Anaphase-promoting complex subunit 10
- Mitotic spindle checkpoint component mad2
- Anaphase-promoting complex subunit hcn1
Sequence:
MVSKSFKYPKKHKFEWINETNRVERVGSGLKRVILCPSMELIAILTCSNHLICCRSNSQRIWDVDFHDLEATELCWNHDGNLIVVGFKNGELKIIDSSTGHLVEQRPASRDLAVLMITWAMQETIVNEKRNDFLFDATAYMPLLGTLPSSAKEERIFSSKAIAQFFEPRKREGENNKKVELLSILDERGIRYINMFSSYKIGESDSLKSALNLGVPISHSITNDLAYHVLICKGGTNISLKTLYMPLLKNDLGSIVDIATMSTRMQHLVRYLEEVLNAMYEEFDNVFKSEASFIKTFDALVSKYSDTTFFSLQLELYQFIMNGIPSDLLKEWINERVGDRVLKNWERAMVNSYTSLIIFCQEFVIPACERLTVLLSSARGKSIWGHMKGNTLLDAKLVEDCLATLGYLQNNVFSFLNCLFEEKKYMKHFISWLNYAIVEFNTSEPSSIPPQEIIEHINETVIYIRHSLFRSKLTSYFMGTKPLQLRDPDYYSLKDFANQDDSNSVDDFVSFKTLKESLRDSFNVIFSYPSLTCQKQWLKTGDLVLFEGTDWNVSSLIPKSCNEKNQLFSLFFRKDTPNIFLIISQLMENTMLPVSGCHFGLDYAELLGSSLLDFQPATVLDMKLLNGSSILILGKLKEKCFLCEICLADVPLTFFEHQQKNSYLDAISHLPFIPLNSCLWLHEFEKDFLPSTLEYALSENSDYGVLISRESSRYRLFSF
Protein: Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2) (Q9Y698)
Organism: Homo sapiens (Human)
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Subcellular location: Membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:Q71RJ2}.
Interaction partners:
- Disks large homolog 4
- Glutamate receptor 1
- Glutamate receptor 2
- Glutamate receptor 3
- Glutamate receptor 4
- Protein shisa-9
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent L-type calcium channel subunit beta-4
- Disks large homolog 1
- Disintegrin and metalloproteinase domain-containing protein 22
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
Protein: Plastid transcriptionally active 18 (Q9SKY2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Keratin-associated protein, putative
- Fructokinase-like 1, chloroplastic
- Single-stranded DNA-binding protein WHY1, chloroplastic
- Fructokinase-like 2, chloroplastic
- Plastid transcriptionally active 3
- Membrane-associated protein VIPP1, chloroplastic
- Proline-rich receptor-like protein kinase PERK15
- Pentatricopeptide repeat-containing protein At1g74850, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 16, chloroplastic
- Protein disulfide isomerase pTAC5, chloroplastic
Sequence:
MASLIMTTPFPGSVTTCKKTNNLSVQRAFRVTCMQTEKPLEELYNVKVERKVSQKRLEELGVSRWSVWKTGKCKLPWDWQVDQLVYIEQGEVRVVPEGSKRYMQFLAGDLVRYPKWLEADLFFNAPYIERYCFKAYGDD
Protein: Rho GTPase activating protein at 71E, isoform F (M9PFR0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSWAERVHRRAADLGNVVTSCGHPATAPAYPYRLEKVKFGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAAHASTGMTSEALGVSVAPSFFQSCVSDGKTARMEDVLKFKVSTKIMQNIIDKFATHDIFGRDNYEYYARVTGRILKVQDEWICSFQYPPPPRGKLAQQKYALQHSLEAEKTWLQCQCERWGLRP
Protein: RE12101p (WASp, isoform A) (WASp, isoform B) (WASp, isoform D) (Q9VAT0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cdc42 homolog
- Actin-related protein 2
- Cdc42-interacting protein 4, isoform B
- Protein nervous wreck
- Verprolin 1, isoform G
- Amphiphysin
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit
- Dreadlocks, isoform B
Sequence:
MSSGMRSQDGPRAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTGVVCFVKDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECDSFFRIVDATIETRNRKRQEKRNRQKSQQAPNAPLPQVQREPARPPPMQGGLSSTDGVQLRNNKINSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKRKVTKADISRPTNFVHLSHVGWDAQKGFDLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVKQYSVESPTETAAPMPPPVPTRHPSNGNQRTAPPLPPARQPPPAVPVTVPGAARAPPPPNRPPPISTAPPPPPVSAPVVAPPPPPPPPPAAVPPPPPPPMPVGEIPVITTTHAPTQAARPAAPAAPDPRNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQGTVLKPAKERELGSQRNSDSGAGTDALADALRRALAARGNAIHSDEDETESSDNEGEWD
Protein: Zinc finger transcription factor lin-29 (abnormal cell lineage 29) (G5EGB2)
Organism: Caenorhabditis elegans
Function: Transcription factor which regulates the expression of various genes, including those involved in cuticle synthesis and maintenance, such as collagens, and in lipid metabolism. Binds to promoter regions of genes, at 5'-[(T/G)TTTTTT(A/T/C/G)]-3' consensus sequences. Heterochronic protein which controls the choice of stage specific cell fates, including at the juvenile to adult transition. Promotes differentiation, together with transcriptional cofactor mab-10, perhaps as part of a transcriptional complex. Required for vulval morphogenesis and egg laying; perhaps by acting in a subset of the lateral seam cells. Involved in the exit of seam cells from the cell cycle. Required for specification of uterine pi-cell fate, acting upstream of lin-12 Notch signaling, perhaps via maintenance of lag-2 expression in the anchor cell (AC). Involved in morphogenesis of the specialized male tail used in mating. Acts cell non-autonomously from the hypodermis to regulate expression of genes in the intestine, including genes involved in lipid metabolism. May regulate vitellogenesis via the mTORC2 signaling mediated pathway, independently of daf-16. May promote nuclear accumulation of mab-10 in seam cells post-transcriptionally. Dispensable for seam cell fusion.
Subcellular location: Nucleus {ECO:0000269|PubMed:32223899, ECO:0000269|PubMed:8756296, ECO:0000269|PubMed:9334281, ECO:0000269|PubMed:9986728}. Note=Accumulates in nuclei of hypodermal cells in a temporally restricted fashion, beginning during the larval L4 stage. {ECO:0000269|PubMed:8756296}.
Interaction partners:
- Protein lin-41
- NAB transcription cofactor mab-10
- Protein lin-14
- Hunchback-like protein
- Protein lin-28
- Period protein homolog lin-42
- Nuclear hormone receptor family member daf-12
- Polyglutamine-repeat protein pqn-41
- F-box protein dre-1
Sequence:
MDQTVLDSAFNSPVDSGIAGTTTGSGSTTHFGVGTNFKVSVRSSSRSTDGTDSTDGANSDNVTGSTGSTPAHHSITNLNMALSQHSIDSATAASSTNPFPHFNQADLLNFHQNSLLPHHMFSQFGRYPQFEQKPDVGVLQQQMQMREAKPYKCTQCVKAFANSSYLSQHMRIHLGIKPFGPCNYCGKKFTQLSHLQQHIRTHTGEKPYKCKFTGCDKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFTDEQSLLDHIPKHKESKHLKIHICPFCGKSYTQQTYLQKHMTKHADRSKASNFGNDVVPADPFDPSLLSWNPMQGMGDNAHDSSSFNISSLTDQFAANTMIGSQSTNYNPAFQNSAFSQLFNIRNNRYLSEYPTSTKNGERAPGFNMITPLENIQRYNGSSSSATAVVTATGSAVVSSTPSSTSSSSAGSSSSQGGVFNPQSLINNMKNHSY
Protein: Claudin (D3YXJ9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell junction, tight junction {ECO:0000256|RuleBase:RU060637}. Cell membrane {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU060637}.
Interaction partners:
- Claudin
- Claudin-23
- Tight junction protein 1
- Tight junction protein ZO-3
- Claudin-17
- Occludin
- Claudin-13
- Claudin-16
Sequence:
MAFIFRTAMQSVGLSLSLLGWVLAIITTYLPHWKNLNLELNEMENWTMGLWKSCVIQEEVGRQCKDFDSFLALPAELQVSRVLMSLCNGLGLLGLLASGCGLDCLRLGETQEGLKKRLLTLGGTLLWTSGVMVLVPVSWVAHKTVREFWDETMPEIVPRWEFGEALFLGWFAGFCLVLGGCVLHCAACSSPAPAASSHYAGAGPRDHGSYLENGTVQPKV
Protein: Ras-like protein (EC 3.6.5.2) (Q12526)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- Adenylate cyclase
- cAMP-dependent protein kinase
- Rho GTPase activator Rga
- cAMP-dependent protein kinase
- Ras small monomeric GTPase RasB
- SH3 domain protein
- GTPase activating protein
- Leucine Rich Repeat domain protein
- Guanine nucleotide exchange factor Cdc24, putative
Sequence:
MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVGNKCDLDKERVVSEQEGESLARQFGCKFIETSAKSRINVENAFYDLVREIRRYNKEMSNPSGSGAFGARAPDSKMDVSEPGESAGCCGKCIVM
Protein: Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt) (E5KS95)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03135}.
Interaction partners:
Sequence:
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVGSYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFECGEGEEAAETE
Protein: Manganese lipoxygenase (MnLOX) (EC 1.13.11.-) (EC 1.13.11.45) (EC 1.13.11.58) (Manganese 9S/11S-lipoxygenase) (9S/11S-MnLOX) (T0JRM4)
Organism: Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata)
Function: Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 9-, 11- and 13-hydroperoxy fatty acids. Oxidizes linoleic acid to mainly 9S- and 13R-HPODE and alpha-linolenic acid to 11R-HPOTrE.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8X151}.
Interaction partners:
- Filamentous hemagglutinin
Sequence:
MRLLLSIAGLTTVVNALAVRADGNVTSSTAVATPTAWTGFPVPTEYTLPQDDHDFQERKEEIKLKRDTITYVPSIIGETSLFIGGSVGTQIVRQEQAKWIQDLTPVQQDAFREGNASLKAIQDHGGLKTLEDYKILYDGHWSGSVPGGIAQGQFNNFTSDLLFAMERLSTNPYVVRRLNPESDKIPFSVDANNVTHLTGTTLDTLFKSGSLFLADHSYQAEYTAQDGRYSAACQALFFLDQRSGQFLPLAIKTNVGSDLVYTPLDDPNDWLLAKIMYNVNDFFHGQIYHLANSHAVAEIVNLAAIRTLSSRHPVFGLLQRLMFQAYAIRATGEIALFNPGGLFDQSFAFSNVYARKFATDFYPTVAGPFQANYFEEDLRARGLLNASYGPELPHLPFHEDGHKIINAIRTFIGTFVDTVYESDKVLAEDSELQAWIAEANGPAKVINFPSAPLNTRKQLAEILTHMAWLTGVSHHVLNQGEPFTTSGVLPLHPASLYAPVPTAKGGIKDLLPWLPNEQKSVEQISLLARFNRPKIVENNETLLHMFDVKTLLSGTGEAVKAANEQFMIAMGTISKEISTRKFDDQGLSQGMPFIWTGMDPGVIPFYLSV
Protein: Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein MH-23) (P09026)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-B4
- Homeobox protein Hox-B5
- Homeobox protein Hox-B6
- Homeobox protein Hox-B8
- Homeobox protein Hox-B2
Sequence:
MQKATYYDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAAPMGPNQHHGPCDPHPTYTDLSSHHAPPQGRIQEAPKLTHL
Protein: Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) (P39748)
Organism: Homo sapiens (Human)
Function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Subcellular location: [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; SUBCELLULAR LOCATION: [Isoform FENMIT]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:23675412}.
Interaction partners:
- Proliferating cell nuclear antigen
- DNA ligase 1
- DNA repair nuclease/redox regulator APEX1
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- DNA polymerase delta catalytic subunit
- DNA replication ATP-dependent helicase/nuclease DNA2
- DNA polymerase delta subunit 2
- DNA polymerase beta
- Double-strand break repair protein MRE11
- DNA polymerase delta subunit 3
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
Protein: Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (H9D1R1)
Organism: Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus)
Function: Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. May function as an important antioxidant, and may be involved in the responses to viral infection.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O95881, ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
Sequence:
MQTSLANIVLFSSLQVLLSLTCFQEVVEAASGKGFGDNIHWRTLDDGKKEAEASGLPIMLIIHKSWCGACKALKPKFAESKEISELAHNFVMINLEDEEEPKDDAFSPDGGYIPRILFLDPSGKVHPEITNKNGNPNYKYFYSNAEQVISGMKEAQEKLTGDAFKQRHTGDEL
Protein: Probable protein phosphatase 2C 41 (AtPP2C41) (EC 3.1.3.16) (Q9LRZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transmembrane protein
- Transmembrane protein
- At5g65580
- Transmembrane protein
- Transmembrane protein
- At2g32150/F22D22.10 superfamily protein)
- At1g73120
- Sm-like protein LSM1A
- Sm-like protein LSM1B
Sequence:
MVLLPAFLDGLARTVSTKKGKKLSEDEDGGREIAKSMIKDSKKNSTLLGTSGFVSSESSKRFTSICSNRGEKGINQDRAIVWEGFGCQEDITFCGMFDGHGPWGHVIAKRVKKSFPSSLLCQWQQTLASLSSSPECSSPFDLWKQACLKTFSIIDLDLKISPSIDSYCSGCTALTAVLQGDHLVIANAGDSRAVIATTSDDGNGLVPVQLSVDFKPNIPEEAERIKQSDGRLFCLDDEPGVYRVGMPNGGSLGLAVSRAFGDYCLKDFGLVSEPEVTYRKITDKDQFLILATDGMWDVMTNNEAVEIVRGVKERRKSAKRLVERAVTLWRRKRRSIAMDDISVLCLFFRPS
Protein: DNA gyrase subunit A, chloroplastic/mitochondrial (EC 5.6.2.2) (Q9CAF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:15136745}. Mitochondrion {ECO:0000269|PubMed:15136745}. Nucleus {ECO:0000305|PubMed:15136745}.
Interaction partners:
- DNA gyrase subunit B, chloroplastic
- DNA gyrase subunit B, mitochondrial
- DNA topoisomerase 2
- Mediator of RNA polymerase II transcription subunit 6
- rRNA 2'-O-methyltransferase fibrillarin 2
- Small RNA degrading nuclease 3
- Heat shock 70 kDa protein BIP2
- Heat shock 70 kDa protein BIP3
- Heat shock 70 kDa protein BIP1
- Pre-mRNA-processing protein 40A
Sequence:
MTPVLCHSTASIPNPNSLMSLSSTLRLSSSLLRRSFFRFPLTDPLCRLRRTEPSATRFFSSRTPRSGKFVVGAGKRGDEQVKEESGANNGGLVVSGDESRIVPFELHKEATESYMSYALSVLLGRALPDVRDGLKPVHRRILFAMHELGMSSKKPYKKCARVVGEVLGKFHPHGDTAVYDSLVRMAQSFSLRCPLIQGHGNFGSIDADPPAAMRYTECRLDPLAEAVLLSDLDQDTVDFVANFDNSQKEPAVLPARLPALLLNGASGIAVGMATNIPPHNLGELVDVLCALIHNPEATLQELLEYMPAPDFPTGGIIMGNLGVLDAYRTGRGRVVVRGKAEVELLDPKTKRNAVIITEIPYQTNKATLVQKIAELVENKTLEGISDIRDESDRNGMRVVIELKRGGDPALVLNNLYRHTALQSSFSCNMVGICDGEPKLMGLKELLQAFIDFRCSVVERRARFKLSHAQQRKHIIEGIVVGLDNVDEVIELITKASSHSSATAALQSEYGLSEKQAEAILEITLRRLTALERKKFTDESSSLTEQITKLEQLLSTRTNILKLIEQEAIELKDRFSSPRRSMLEDSDSGDLEDIDVIPNEEMLMAVSEKGYVKRMKADTFNLQHRGTIGKSVGKLRVDDAMSDFLVCHAHDHVLFFSDRGIVYSTRAYKIPECSRNAAGTPLVQILSMSEGERVTSIVPVSEFAEDRYLLMLTVNGCIKKVSLKLFSGIRSTGIIAIQLNSGDELKWVRCCSSDDLVAMASQNGMVALSTCDGVRTLSRNTKGVTAMRLKNEDKIASMDIIPASLRKDMEEKSEDASLVKQSTGPWLLFVCENGYGKRVPLSSFRRSRLNRVGLSGYKFAEDDRLAAVFVVGYSLAEDGESDEQVVLVSQSGTVNRIKVRDISIQSRRARGVILMRLDHAGKIQSASLISAADEEETEGTLSNEAVEAVSL
Protein: Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (O14561)
Organism: Homo sapiens (Human)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:28892042}.
Interaction partners:
- NADH dehydrogenase 1 subunit C1, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase 1 alpha subcomplex subunit 12
Sequence:
MASRVLSAYVSRLPAAFAPLPRVRMLAVARPLSTALCSAGTQTRLGTLQPALVLAQVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
Protein: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (N-acetylglucosamine-1-phosphate transferase) (F7EMK2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MWAFPELPLPLPLLVNLIGSLLGFVATVTLIPAFRSHFIAARLCGQDLNKLSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDYRDDHVFSLYFMMPFFFTTLGLLYHNWYPSQVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLFQIIPCPRHRMPRLNTKTGKLEMSYSKFKTKSLSFLGTFILKVAESLRLVTVHRGESEDGAFTECNNMTLINLLLKVFGPTHERNLTLFLLLLQLVRLFYDV
Protein: Transmembrane protein (Q585G3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTATTTPSNSSSLKNDCEEGAVGAQLLYNSTEKTASRLLLSAERYVKAGQALLVLAVASAGVVGLLASWQYRRIHRVWRIRHPRRLAQQRQAMWAFGTFGTATFLLLLSPIGPGGLHEARLEDVKRLDDIAVRALILKRRYESAAALAATLRENETTGWWWRTTAQQETEAREMFERCEDEWRALMKERIAIDPNV
Protein: Transducin-like enhancer protein 6 (Groucho-related protein 6) (Q9WVB3)
Organism: Mus musculus (Mouse)
Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16314515, ECO:0000269|PubMed:18804437}. Nucleus {ECO:0000269|PubMed:16314515}. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (PubMed:18804437, PubMed:25208553). At the 2-cell and morular stage, still detected in the subcortex, but excluded from cell-cell contact regions (PubMed:18804437, PubMed:25208553). Expression largely disappears in blastocysts (PubMed:25208553). {ECO:0000269|PubMed:18804437, ECO:0000269|PubMed:25208553}.
Interaction partners:
- Oocyte-expressed protein homolog
- KH domain-containing protein 3
- NACHT, LRR and PYD domains-containing protein 5
- Inactive protein-arginine deiminase type-6
- TLE family member 5
- NACHT
- Zinc finger BED domain-containing protein 3
Sequence:
MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY