wanglab/gogpt-training-data huggingface dataset:
Protein: rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1) (Q5ND52)
Organism: Mus musculus (Mouse)
Function: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24036117}.
Interaction partners:
- Mitochondrial assembly of ribosomal large subunit protein 1
- Large ribosomal subunit protein uL29m
- Probable ATP-dependent RNA helicase DDX28
- Mitochondrial ribosome-associated GTPase 1
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL24m
Sequence:
MAAPAKGMWCSLGSLLRVVQTRDLNARRWVRALRRSPVRVLSPSGQVEERKRAPDQQPRKAVPKASSQGQRQKQPLETSPSQTPHTWEEAGLRYDKAFPGDRRLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPKAFFFSRLEYVKELPVDKLKDVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDPVKMTYPETPLHHTLPLVLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIVNNVEWETVPNHLPPDTRVYVADNCGHYAQVQMSDKTGDRDWACDRRFLKFHKYEEDLDTKTRKDWLPKLEVQSYDLDWTGAPAAVVIGGETHGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRIKVEDLSRDRSYH
Protein: SCF ubiquitin ligase complex protein SKP1a (Glycoprotein FP21 isoform A) [Cleaved into: SCF ubiquitin ligase complex protein SKP1a(4-162); SCF ubiquitin ligase complex protein SKP1a(6-162)] (P52285)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- VWFA domain-containing protein
- Protein SGT1 homolog
- SCF ubiquitin ligase complex protein SKP1b
- Cullin-5
- UBR-type domain-containing protein
- RING-box protein 1
- Uncharacterized protein
- [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
- Cullin-1
- DDRGK domain-containing protein 1
Sequence:
MSLVKLESSDEKVFEIEKEIACMSVTIKNMIEDIGESDSPIPLPNVTSTILEKVLDYCRHHHQHPSPQGDDKKDEKRLDDIPPYDRDFCKVDQPTLFELILAANYLDIKPLLDVTCKTVANMIRGKTPEEIRKIFNIKNDFTPEEEEQIRKENEWCEDKGGN
Protein: High mobility group box 1a (High mobility group protein B1a) (High-mobility group box 1) (Q6NX86)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Beclin-1
- High mobility group box 1b
- Toll-like receptor 2.
- Toll-like receptor 4b, duplicate a.
- Toll-like receptor 4
- Toll-like receptor 4
- Toll-like receptor 9
- High mobility group box 2a.
- Deafness, autosomal dominant 5
- Cellular tumor antigen p53
Sequence:
MGKDPTKPRGKMSSYAYFVQTCREEHKKKHPEATVNFSEFSKKCSERWKTMSAKEKGKFEDMAKLDKARYEREMKNYIPPKGEKKKRFKDPNAPKRPPSAFFIFCSEFRPKVKEETPGLSIGDVAKRLGEMWNKISSEEKQPYEKKAAKLKEKYEKDIAAYRSKGKVGGGAAKAPSKPDKANDEDEDDDEEEDEDDDDEEEEDDE
Protein: Metallothionein-1 (MT-1) (Metallothionein-I) (MT-I) (P17511)
Organism: Caenorhabditis elegans
Function: This protein binds cations of several transition elements.
Interaction partners:
- Superoxide dismutase 2, mitochondrial
- Downstream Of DAF-16
- Forkhead box protein O
- Insulin-like receptor
- Glutathione gamma-glutamylcysteinyltransferase
- Peroxisomal catalase 1
- Catalase-2
- Heat shock protein 12.6
- Zinc transporter 2
- Zinc transporter ttm-1
Sequence:
MACKCDCKNKQCKCGDKCECSGDKCCEKYCCEEASEKKCCPAGCKGDCKCANCHCAEQKQCGDKTHQHQGTAAAH
Protein: SIX homeobox 5 (A0A0G2K7K3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Eyes absent homolog
- Zinc finger protein 143
- Brachyury 2
Sequence:
MATSPAEPSAGPAAQGEAAAATEEEEEEARQLLQTLQAAEGEAAAAGAGEGAAADSGSPSGPGSPRETGTEAPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASVAAEAPTQSSIFLAGATPSATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLTLGEGSSLGPLLLTGGGGTPQPQPSPQGVSETKTSLVLDPQTGEVRLDEAQSEAPEAKGVHGTTPGEEIPGTLPQVVPGPPPASTFPLTPGAVPSVAAPQVVPLSPSSGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAATAGPTNVHLINSSVGVTALQLPSSATPGNLLLANPVSGSPIVTGVAVQQGRILLTATFPTRMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPVSTQPLPPAPAVTSATSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDHQGLLLGATAGTEVDEGLEAEAKVLTQLQSVPVEEPLEL
Protein: Glucose-6-phosphate/phosphate translocator 1, chloroplastic (AtGPT1) (Q9M5A9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glucose 6-phosphate (Glc6P) transporter. Transports also inorganic phosphate, 3-phosphoglycerate, triose phosphates and, to a leser extent, phosphoenolpyruvate. Responsible for the transport of Glc6P into plastids of heterotrophic tissues where it can be used as a carbon source for starch biosynthesis, as substrate for fatty acid biosynthesis or as substrate for NADPH generation via the oxidative pentose phosphate pathway (OPPP). Required for pollen maturation and embryo sac development. Preferentially exchanges Glc6P for ribulose-5-phosphate (Ru5P) in reconstituted yeast proteoliposomes. May supply the substrate (Glc6P) for OPPP reactions inside peroxisomes and exchange it with the product Ru5P which leaves the organelle.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:32111666}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:32111666}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:32111666}; Multi-pass membrane protein {ECO:0000255}. Note=Targeted to peroxisomes via the endoplasmic reticulum. {ECO:0000269|PubMed:32111666}.
Interaction partners:
- At3g53320
- TRIO/F-actin-binding protein
- At3g09000
- Maltose excess protein 1, chloroplastic
- ADP,ATP carrier protein 1, chloroplastic
- Microtubule-associated protein RP/EB family member 1A
- Plastidic glucose transporter 4
Sequence:
MVLSVKQTLSPKIGLFRRNPSSSLGRSPVSLSFPSTELPKRTVLAVSKPLHLSSSLRAKSPVVRCEAYEADRSEPHPIGDDAAAAETKSEAAKKLKIGIYFATWWALNVVFNIYNKKVLNAYPYPWLTSTLSLAAGSLMMLISWAVGIVETPKTDFDFWKTLFPVAVAHTIGHVAATVSMSKVAVSFTHIIKSGEPAFSVLVSRFILGETFPTSVYLSLIPIIGGCALSALTELNFNMIGFMGAMISNLAFVFRNIFSKKGMKGKSVSGMNYYACLSMLSLLILTPFAIAVEGPQMWVDGWQTALATVGPQFVWWVVAQSVFYHLYNQVSYMSLDQISPLTFSVGNTMKRISVIVSSIIIFRTPVQPVNALGAAIAILGTFLYSQAKL
Protein: Interleukin-7 (IL-7) (P13232)
Organism: Homo sapiens (Human)
Function: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.
Subcellular location: Secreted {ECO:0000269|PubMed:25870237}.
Interaction partners:
- Cytokine receptor common subunit gamma
- Interleukin-7 receptor subunit alpha
- Interleukin-4
- Interleukin-9
- Interleukin-2
- Tyrosine-protein kinase JAK3
- Interleukin-5
- Hepatocyte growth factor
- Interleukin-10
- Interleukin-3
Sequence:
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
Protein: Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15) (Q9UBU8)
Organism: Homo sapiens (Human)
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
Subcellular location: Nucleus {ECO:0000305|PubMed:21041482}.
Interaction partners:
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein 3
- Histone acetyltransferase KAT5
- YEATS domain-containing protein 4
- PHD finger protein 12
- MRG/MORF4L-binding protein
- Histone deacetylase 2
- DNA methyltransferase 1-associated protein 1
- Transformation/transcription domain-associated protein
- Partner and localizer of BRCA2
Sequence:
MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV
Protein: PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) (Q96IZ0)
Organism: Homo sapiens (Human)
Function: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.
Interaction partners:
- SPRY domain-containing SOCS box protein 1
- Death-associated protein kinase 3
- THAP domain-containing protein 1
- Endoplasmic reticulum chaperone BiP
- Wilms tumor protein
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
- SPRY domain-containing SOCS box protein 2
- D
- SPRY domain-containing SOCS box protein 4
- Protein kinase C zeta type
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
Protein: Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) (Q7KUC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- pyridoxal 5'-phosphate synthase
- pyridoxal 5'-phosphate synthase
- LP01149p
- Uncharacterized protein
- Proliferating cell nuclear antigen
- Proliferating cell nuclear antigen 2
- Pyridoxal phosphate homeostasis protein
Sequence:
MAGATNADIKRVLSIQSHVVHGYVGNKVATYPLQLLGFDVDPLNSVQFSNHTGYKTFKGPVSNEKELATIFEGLEENELLPLYSHLLTGYIGNPLFLRQVGHILKKLRQANPGLVYVCDPVMGDNGQLYVPKELLPVYRDEIIPLADIITPNQFEVELLTEKEVRSEAAVWEAMEWFHQRGIKTVVISSSDLGQPGVLRAFLSQQNGPRLAIDIPKQGGKDLVFTGTGDLFASLFLAHSHGSKDIANVFEKTIASLQAVIKRTVASLPNGGNGPVKAAERELKLVQSKTEIEQPQVLLKAQRLN
Protein: NAD(P)H pyrophosphatase NUDT13, mitochondrial (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 13) (Nudix motif 13) (Protein KiSS-16) (Q86X67)
Organism: Homo sapiens (Human)
Function: NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q8JZU0}.
Interaction partners:
- Bifunctional epoxide hydrolase 2
- Glutamine-dependent NAD
- Ribonuclease H1
- 5'-nucleotidase
- Phosphoserine phosphatase
- 5'-deoxynucleotidase HDDC2
Sequence:
MSLYCGIACRRKFFWCYRLLSTYVTKTRYLFELKEDDDACKKAQQTGAFYLFHSLAPLLQTSAHQYLAPRHSLLELERLLGKFGQDAQRIEDSVLIGCSEQQEAWFALDLGLDSSFSISASLHKPEMETELKGSFIELRKALFQLNARDASLLSTAQALLRWHDAHQFCSRSGQPTKKNVAGSKRVCPSNNIIYYPQMAPVAITLVSDGTRCLLARQSSFPKGMYSALAGFCDIGESVEETIRREVAEEVGLEVESLQYYASQHWPFPSGSLMIACHATVKPGQTEIQVNLRELETAAWFSHDEVATALKRKGPYTQQQNGTFPFWLPPKLAISHQLIKEWVEKQTCSSLPA
Protein: Acetyl-CoA acetyltransferase 1, isoform A (Acetyl-CoA acetyltransferase 1, isoform B (EC 2.3.-.-, EC 2.3.1.-, EC 2.3.1.9)) (LD24105p) (Q9W3N9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
- hydroxymethylglutaryl-CoA lyase
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- Acetyl-coenzyme A synthetase
- Acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MSARLLQATRRWSAHRNYSSKIAEVVVVSAARTPIGSFQSQLAPLTATQLGARAIEAAIEKAGIAKTDVQEVIMGNVVSAGLGQAPARQAAIFAGLPTNVCCTTVNKVCSSGMKAVMLGAQSLMLGYADVVVAGGMESMSNVPYYLKRGATPYGGVNLTDGIVFDGLWDVYNKFHMGNCAENTAKKLEITRQQQDDFAIESYKRSAAAWANKVFQDEIAPVKIQQKRKPEIVISEDEEYKRVNFDKFGQLATVFQRENGTVTAGNASTLNDGGAAVVLMSAEAAQKAGIKPLARIVAFQDAETDPIDFPIAPALAIPKLLKRAGVRKEDVAMWEVNEAFSLVVLANIKKLDVDPAKVNVHGGAVSIGHPIGMSGARLVAHLSHSLKKGELGCASICNGGGGASSILIEKL
Protein: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (Q9P242)
Organism: Homo sapiens (Human)
Function: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
Interaction partners:
Sequence:
MISSKMMSSNPEEDPLDTFLQYIEDMGMKAYDGLVIQNASDIARENDRLRNETNLAYLKEKNEKRRRQEEAIKRIGGEVGRGHEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFSVRSQSLHSVGGTDDDSSCGSRRQPPPKPKRDPSTKLSTSSETVSSTAASKSGKTPERTEASAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHGPRRTSLPRDSSLSQMGSPAGDPEEEEPVYIEMVGNILRDFRKEDDDQSEAVYEEMKYPIFDDLGQDAKCDFDHHSCSSQCATPTVPDLDFAKASVPCPPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPAGASPSTLPSHVPGHAKLEKEQAAALGPASATPALSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSPSVPHSTPRPVSQDGAKMVNAAVNTYGAAPGGSRSRTPTSPLEELTSLFSSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDNKERGHHGASSSREPVKAQEWDGTPGTPVVTSRLGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQSSDLQQSQVPSSLANRD
Protein: IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28) (O36972)
Organism: African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
Function: IkB-like protein that inhibits the binding of NF-kappa-B to DNA, thereby downregulating pro-inflammatory cytokine production. Forms a heterodimer with the NF-kappa-B subunit RELA/p65 and prevents the activation of the NF-kappa-B transcription factor (By similarity). Inhibits calcineurin function, which is required for the induction of nuclear factor of activated T cells (NFAT)-dependent immune response genes. Prevents the binding of substrates to calcineurin without affecting the phosphatase activity. Does not contain the serine residues that are phosphorylated by host IkB kinase and thus is not degraded following stimulation of the NFkB pathway (By similarity).
Subcellular location: Host nucleus {ECO:0000250|UniProtKB:Q76U48}. Host cytoplasm {ECO:0000250|UniProtKB:Q76U48}. Note=Binding to host PPP3CA/Calcineurin may mask the second nuclear localization signal thereby contributing to the cytoplasmic retention of A238L. {ECO:0000250|UniProtKB:Q76U48}.
Interaction partners:
Sequence:
MDTIGLFSVEAEHLFVEWVKKCIKKGDLTLFETLFNADPWIVNRCNKNKITVFMLICIYGRLDFLRFLFKQESYPGEIVNHYRRDKDGNSAWHYLAEKNNHLLLEEVLDYFGKNGIRVCFPNFNGVTPIMKAAMRGRTLSVLSLLKYGANPNRKDYLKGFTTWDWAVFTGHADLVKTLNKGYQKPLFMHFPLYKLDVFHRRFKKKPKIIITGCEDNVYEKLPEQNSNFLCVKKLNKYGK
Protein: TNFAIP3 interacting protein 1 (A0A0A0MRZ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKASGERYHVEPHPEHLCGAYPYAYPPMPAMVPHHGFEDWSQIRYPPPPMAMEHPPPLPNSRLFHLHQFCRSRNTPGVYPVEGFEIQIRAPK
Protein: DUF3710 domain-containing protein (O07198)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MAFGRRTGKDGGKRKAGHAPVQPADEHVRPEDTVVASAAAASGVEDQEELQGPFDIDDFDDPSVAVLARLDLGSVLIPMPAAGQVQVELTESGVPSAVWVITPNGRYSIAAYAAPKTGGLWREVAGELADSLRKDSAKVSIKDGPWGREVIGIAAGVVRFIGVDGYRWMIRCVVNGPQETVDALTEEAREALADTVVRRGDTPLPVRTPLPVHLPEPMAAQLREAAAAQADTQRQAAAGVARRGAQGSAMQQLRSTTGG
Protein: TATA-box binding protein associated factor 9 (Transcription initiation factor TFIID subunit 9) (D6RIE8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESGKTASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKATVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQRNQTPLPLIKPYSGPRLPPDRYCLTAPNYRLKSLQKKASTSAGRITVPRLSVGSVTSRPSTPTLGTPTPQTMSVSTKVGTPMSLTGQRFTVQMPTSQSP
Protein: Agamous-like MADS-box protein AGL6 (P29386)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor. Forms a heterodimer via the K-box domain with AG, that could be involved in genes regulation during floral meristem development.
Subcellular location: Nucleus.
Interaction partners:
- Agamous-like MADS-box protein AGL80
- Protein LEAFY
- MADS-box protein
- Protein TERMINAL FLOWER 1
- Floral homeotic protein APETALA 2
Sequence:
MGRGRVEMKRIENKINRQVTFSKRRNGLLKKAYELSVLCDAEVALIIFSSRGKLYEFGSVGIESTIERYNRCYNCSLSNNKPEETTQSWCQEVTKLKSKYESLVRTNRNLLGEDLGEMGVKELQALERQLEAALTATRQRKTQVMMEEMEDLRKKERQLGDINKQLKIKFETEGHAFKTFQDLWANSAASVAGDPNNSEFPVEPSHPNVLDCNTEPFLQIGFQQHYYVQGEGSSVSKSNVAGETNFVQGWVL
Protein: CABIT domain-containing protein (Q58AA4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHNGYHSYFPPNHYYAQSQPSSSYNPQPQIQQPQTQIYGLVVGYNKYGNRNYLFYTKNIDGFVEISGNIQSLQIGRWLKLTVCQNFVGQYVLDSSNSCGYENWDVLPNHRNSSARFFPKYEANDEGEILITARFDVIVDRKNNLYDFTSYDISYDHIIDDFSLIKSSCQHYDGRSFIVEAQASLAGWVALSVHEDPQKLHTCDALPNPVVDSDVQYLHDTRLLDIMTGNGYVQTPETDVQDQQSSQHQEDVHSQMNSQTSDSYNSSRVVSENREIPPETFRSQSIELNQVDSSLSQTTISSRAAPVIDSNQLSDEDEIDDEDTYGTRGTSNIPMRPFIKDLAPTMLQLLRQDKTDSEKPQSALCTVVQKIDGFAILYTAKRDVINVLLQERSCEGLERSPQLGDVAFFDILPRRIETKDRLIFKIPYTHIAVKKKPDTPDSLLKIDCFKNSVRCFGGVLEMKVKIALSKPELVVEQYHDNTEMNSDHHFYYLKATNGVLVTIPKERLLNHLNSKLSADFDLIAWVVHRKPIGNVSLHIGKGGEAYQQFTNGDIRELPPLSSNQYFMNVRK
Protein: Protein DETOXIFICATION 51 (AtDTX51) (Multidrug and toxic compound extrusion protein 51) (MATE protein 51) (Protein ABNORMAL SHOOT 3) (Protein ACTIVATED DISEASE SUSCEPTIBILITY 1) (Protein ADS1) (Protein ALTERED DEVELOPMENT PROGRAM 1) (Protein ADP1) (Protein NOVEL ION CARRIER 4) (Protein NIC4) (Q9SZE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as a multidrug and toxin extrusion transporter that negatively regulates plant disease resistance. Plays an important role in maintaining normal plant architecture, possibly by regulating local auxin biosynthesis. May act as a negative regulator of hypocotyl cell elongation in the light.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:24391508}; Multi-pass membrane protein {ECO:0000269|PubMed:24391508}. Late endosome membrane {ECO:0000269|PubMed:26160579}; Multi-pass membrane protein {ECO:0000269|PubMed:26160579}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Wax ester synthase/diacylglycerol acyltransferase 3
- Wax ester synthase/diacylglycerol acyltransferase 2
- Wax ester synthase/diacylglycerol acyltransferase 8
- Protein DETOXIFICATION 44, chloroplastic
- Protein DETOXIFICATION 42
- Wax ester synthase/diacylglycerol acyltransferase 5
- Wax ester synthase/diacylglycerol acyltransferase 4
- Protein DETOXIFICATION 46, chloroplastic
- Protein DETOXIFICATION 43
Sequence:
MCNPSTTTTTTGSENQESRTGLFLDLFSINSFEPTKRNLRHCENRGSPLMAEAVTEAKSLFTLAFPIAVTALVLYLRSAVSMFFLGQLGDLELAAGSLAIAFANITGYSVLSGLALGMEPLCSQAFGAHRFKLLSLTLHRTVVFLLVCCVPISVLWFNVGKISVYLHQDPDIAKLAQTYLIFSLPDLLTNTLLHPIRIYLRAQGIIHPVTLASLSGAVFHLPANLFLVSYLRLGLTGVAVASSITNIFVVAFLVCYVWASGLHAPTWTDPTRDCFRGWAPLLRLAGPSCVSVCLEWWWYEIMIVLCGLLVNPRSTVAAMGVLIQTTSFLYVFPSSLSFAVSTRVGNELGANRPKTAKLTATVAIVFAAVTGIIAAAFAYSVRNAWGRIFTGDKEILQLTAAALPILGLCEIGNCPQTVGCGVVRGTARPSTAANVNLGAFYLVGMPVAVGLGFWAGIGFNGLWVGLLAAQISCAGLMMYVVGTTDWESEAKKAQTLTCAETVENDIIKAVVASTIDGECDEAEPLIRITVLY
Protein: GTPase-activating protein NEL1 (Non-ERES-localized SEC23 homolog 1) (P38769)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a GTPase-activating protein (GAP) for SAR1. Contrary to its SEC23 homolog, NEL1 does not associate with SEC24 and its homologs, nor does it associate with the COPII components, suggesting that it is unlikely that NEL1 functions as a structural component of the vesicle coat machinery. May function as a signaling molecule.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24947508}. Nucleus {ECO:0000269|PubMed:24947508}. Note=Is diffusely localized throughout the cytosol, and does not accumulate at ER exit sites (ERES). {ECO:0000269|PubMed:24947508}.
Interaction partners:
- SED5-binding protein 3
- Protein transport protein SEC13
- Small COPII coat GTPase SAR1
- SED5-binding protein 2
- Protein transport protein SEC24
- Protein transport protein SEC31
- COPII coat assembly protein SEC16
- Protein transport protein SEC22
Sequence:
MCSPTNFLYEPFSSDAVTQNYDQNLKCTKCGAYYSMACSLREQNVWTCLFCNQSNSNAELPLVPSNTYTLTSAKKEILSRRTIMIIDAICDPHELNYLVSILCNNYITRQQEPLSIITIQQSGHVILHNAVNHRRDAVFSINEFMTKYNLDKLNASYFEKKISEINQESYWFDKSTQGSLRKLLREICKIANKVNISSKRDKRCTGLALFVSSVLASQCSLSAYCHIVSFLNGPCTKGGGKVMSRERGESMRQNHHFESKSSQLQLSKSPTKFYKKMLEKFANQSLIYEFFIASLDQIGILEMSPLITSSMAVSQFDSFNDERFAMSFQKYLNLRDHNAIYNCHSKIMTAKNAIVVKDFPKYSLNPKNLSLPLEISLGHNSAEAPIQFQTTFENQTEKYIRIETLLLPKANRSFGAQNEIVFSMKKIASRIIDSFAYSSKHTKELMKQLFLLPNQIRGKDVDMVNLIQWCYHIYRSPILSVRNTSPDERYLFLHRIINASKDTCLSLCKPFIWSYSDLKHDWIVLDVPLTRAQILQDDKTTICVDGGSYLVLRRGKLLEKEGRELCCKLLNDLQRFPQPLYVETKTGGSQDRFLKSKIIPLDITDKETLGTEDMTFNEYFNLFTDLSGSK
Protein: Interleukin-18 (IL-18) (Q5S4P2)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR015162}.
Interaction partners:
Sequence:
MSCEEIAVCAVRLRENLCLYFEDDELECDAFCKDKTIKRFFRNVNSQLLVVRPDLNVAAFEDVTDQEVKSGSGMYFDIHCYKTTAPSAGMPVAFSVQVEDKSYYMCCEKEHGKMVVRFREGEVPKDIPGESNIIFFKKTFTSCSSKAFKSEYSLEQGMFLAFEEEDSLRKLILKKLPREDEVDETTKFVTSHNERHNL
Protein: Rifin (C6KTF5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLHYTKLLLFFFTLNILLTSYHAHNKNKPSITSHHTPRYTSRVLSECDTESSIYDNDEEINSVKEIFERQASQRLREYDERLQEKRQKRKEQRDKNIQKIIHKDKMEKNVAEKIEKGCLMCGCGLGSVAGSIGLFGEVAINIWKPVAFDAAITAALNANAVKIAEAANSAGIQAGKEFVIAGLEKLGVSILDNQSLVSYFTTTPYNTASVITTALYKQHYKICVYDPSRNLFSPFGDVNRHIGICNSVLKQTEAVSQSRKYISHIEGIEKTVQTMVSYAEVSAKAAAKTAEAANKLAIEEAQEKVMEATIYNWYTTIGYTILAILIIVLIMIIIYLILRYRRKKKMKKKAQYTKLLNE