wanglab/gogpt-training-data huggingface dataset:
Protein: Beta-toxin Cb2 (C0HLR4)
Organism: Centruroides baergi (Scorpion) (Centruroides nigrovariatus baergi)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and reduces peak current and shifts the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Has an inhibitory effect on voltage-gated sodium channel hNav1.6/SCN8A, affecting both the activation and inactivation processes. Also reduces the peak current of hNav1.5/SCN5A but does not shift its voltage of activation. This toxin is active against mammals and lethal to mice.
Subcellular location: Secreted {ECO:0000269|PubMed:32479835}.
Interaction partners:
Sequence:
KEGYLVDLHTGCKYTCVGLGDNDYCVRECRLRYYDSAHGYCYAFGCWCTHLYEQAVVWPLPNKRCK
Protein: Histone acetyltransferase type B subunit 2 (P39984)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. HAT2 is required for high affinity binding of the acetyltransferase to histone H4, for the nuclear location of HAT1 and for the HAT1-HIF1 interaction. Alone, it is unable to bind to H4, requiring HAT1 for high affinity interaction with the histone tail. HAT2 has also a HAT1 independent function in life-span regulation.
Subcellular location: Cytoplasm. Nucleus. Note=The nuclear location requires the presence of HAT2.
Interaction partners:
- Histone H4
- Histone acetyltransferase type B catalytic subunit
- HAT1-interacting factor 1
- Origin recognition complex subunit 5
- Origin recognition complex subunit 4
- Origin recognition complex subunit 3
- Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- Histone H3
- Histone chaperone ASF1
Sequence:
MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS
Protein: Myelin-oligodendrocyte glycoprotein (Q16653)
Organism: Homo sapiens (Human)
Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 8]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Myelin basic protein
- Myelin-associated glycoprotein
- Myelin proteolipid protein
- Myelin-associated oligodendrocyte basic protein
- Interleukin-17A
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
- Interferon gamma
- T-cell surface glycoprotein CD4
- Contactin-2
- Interleukin-10
Sequence:
MASLSRPSLPSCLCSFLLLLLLQVSSSYAGQFRVIGPRHPIRALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKVEDPFYWVSPGVLVLLAVLPVLLLQITVGLIFLCLQYRLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFLEELRNPF
Protein: LD43341p (Microcephalin, isoform B) (Q7JUM5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDKFLLRNPTWKTKTYGSVVASSAAAAKKTAASSTRRPLHDSNLGDFRSKAAAPSPKSLSQAPADDQAARDRLMLKPALAVSKAISQHRSEFHQDENEAGAEGSAAKPDPPIGAATPTRQEGHWARLQQDLNSPNAALRLRAIRALKSPTKSAYNTFDVPLAEQSIITMEERNPQEPPSLPELLKDIVVYVEVRTGNDNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIPVVSILWIEACKVQLKICDPKQFPISNIRMYEYPELFGKMPRVKFMQPDSELNQRPRKRQGTPTSSKDNEPGSTNKRAQTGTPTTTTPKNDISRFFRAINHNKPSDDEAIESPATKLLNRISSGCYTPLPAGGTPQLMGTNGSGDAVAQKVQAQKSLQFGEQTDSNTPQAKPSSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVIHEADPTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENRNSIIMAETNIINNTNCLEQSIEITAVEAEASFKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSLSNVTTQTSFLDVEQQVTPLFSSTRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRMSLALANKAELGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVISPAMSNRKSRLSITGSGSSSSVQKRRRSLATPAKSSSSELCATTPLSKAVTNKEAEKSKSNTEISEASLDAVPEVKKSTSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKVGNTTE
Protein: Apolipoprotein L, 1 (Apolipoprotein L1) (Novel protein similar to human apolipoprotein 1 (APOL1)) (Q7T131)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEWLDDFRLSETQREDEEDLEGLMDWWNTVEQWEDMPKNDNMTEKEEAKAFAVTADKVQKGIRVFNKLFSERAEGLWQHVIDLHAIADGLDRFNKKTKIAQITGGSTSAVGGVATITGLILAPFTMGTSLIVTAVGLGVAMAGGLTSASAGITSTVNNSLDRKKVERIVGDYQAKMGDLNKCMKFIKQGITNLRKFNLNKMKKHAYNRDFPCFDNVYEDGAMAGKAILTNANEIMRVMQIANVAGTTAARAVQIASISTGVLTGLFVGMDIYFVAKDSHELKNGAKSEFAAKIREVAEQLHEGLMELNVIRDELRMTTTVKEDQTS
Protein: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Methionine-requiring protein 3) (Sulfate adenylate transferase) (SAT) (P08536)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03106, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Adenylyl-sulfate kinase
- Phosphoadenosine phosphosulfate reductase
- Sulfite reductase subunit beta
- Sulfite reductase flavoprotein component
- 3'
- Protein APA1
- Transcriptional regulator MET32
- Transcriptional activator of sulfur metabolism MET28
- Uroporphyrinogen-III C-methyltransferase
- Transcriptional regulator MET31
Sequence:
MPAPHGGILQDLIARDALKKNELLSEAQSSDILVWNLTPRQLCDIELILNGGFSPLTGFLNENDYSSVVTDSRLADGTLWTIPITLDVDEAFANQIKPDTRIALFQDDEIPIAILTVQDVYKPNKTIEAEKVFRGDPEHPAISYLFNVAGDYYVGGSLEAIQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMHRAHRELTVRAAREANAKVLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPNGIAFLSLLPLAMRMSGDREAVWHAIIRKNYGASHFIVGRDHAGPGKNSKGVDFYGPYDAQELVESYKHELDIEVVPFRMVTYLPDEDRYAPIDQIDTTKTRTLNISGTELRRRLRVGGEIPEWFSYPEVVKILRESNPPRPKQGFSIVLGNSLTVSREQLSIALLSTFLQFGGGRYYKIFEHNNKTELLSLIQDFIGSGSGLIIPNQWEDDKDSVVGKQNVYLLDTSSSADIQLESADEPISHIVQKVVLFLEDNGFFVF
Protein: Solute carrier family 7 member 3a (Solute carrier family 7, member 3) (F1R9X0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Uncharacterized protein.
- Transmembrane protein 266.
- Solute carrier family 25 member 35
Sequence:
MVDKMASFGHILLRRRALDFSGEETRFARCLSTLDLVALGVGSTLGAGVYVLAGEVAREKAGPAIVLCFLVAALSSMLAGLCYAEFGARVPKTGSAYLYSYVTVGEIWAFITGWNLILSYVIGTASVARAWSSTFDNLIEQKISNFFRASMAMKVPGKVLAEYPDLFALILILLLTGLLAFGVSESALVNKIFTGINLIVLGFIIISGFVKGNTANWNLTYEYFINDTNITEPERIESTFGSGGFAPFGLGGILSGAATCFYAFVGFDCIATTSEEAKNPMRSIPVGIVASLLICFFAYFGVSAALTLMMPYYKLNTQSPLPEAFSYVGWAPARYIVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRSLSRMNKRTKTPLLATIASGIVAALMAFLFDLAALVDLMSIGTLLAYSLVAVCVLILRYQPGNLSSSSQTEKLVELVGGEKVAVCGDSGDEYGVELDDSPRKEKFTAKLLLVPSKDSPTEMSGTIVYGTTAIISVLITVLCVVLAQRLESIINLEIVWVTACVILVLLCVLCVIVIFRQPESKEALTFKVPLLPWLPLFSIFVNIYLMMQLDVATWCRFTVWMAIGFAIYFGYGIWHSTEAMNSSVRKYEPALQNKSPIYLGGEESEIEGISP
Protein: Virion infectivity factor (Vif) (SOR protein) [Cleaved into: p17; p7] (P69723)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Function: Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04081}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04081}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04081}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_04081}. Virion {ECO:0000255|HAMAP-Rule:MF_04081}. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion. {ECO:0000255|HAMAP-Rule:MF_04081}.
Interaction partners:
Sequence:
MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
Protein: DNA-directed RNA polymerases I and III subunit RPAC1 (A0A2R8YEZ4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYI
Protein: HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) (Q8WY36)
Organism: Homo sapiens (Human)
Function: Transcription factor that is necessary for cell cycle progression from G1 to S phase.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Gamma-butyrobetaine dioxygenase
Sequence:
MKGSNRNKDHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGADGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRDLPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDVSESPELRQKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKSALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFEKSAKENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKKRQSSESDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSKEKSSDTTKESRPPDFISISASKNISGETPEGIKAEPLTPMEDALPPSLSGQAKPEDSDCHRKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEESWTFSQSGTSGSKKFKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKCVPVPRKKKKTGNVSSEPTKTSKGPFQSQKKNLFHKIVSKYKHKKEKPNVPEKGSGDKWSNKQLFLDAIHPTEAIFSEDRNTMEPVHKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKATETDCNDKCSHNTEVGETRSSTPEMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ
Protein: T-box transcription factor TBX2 (T-box protein 2) (Q60707)
Organism: Mus musculus (Mouse)
Function: Transcription factor which acts as a transcriptional repressor. May also function as a transcriptional activator. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Required for cardiac atrioventricular canal formation. May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium. Plays a role in limb pattern formation. Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3. Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling. Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear. Acts as a negative regulator of PML function in cellular senescence (By similarity). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK. Negatively modulates expression of CDKN2A/p19ARF and CDH1/E-cadherin (By similarity). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (By similarity). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1. Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2. Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD.
Subcellular location: Nucleus {ECO:0000269|PubMed:26486273, ECO:0000269|PubMed:33731112}.
Interaction partners:
- Histone H3.2
- Histone H3.1
- Histone H3.3
- Insulin gene enhancer protein ISL-1
- Homeobox protein Nkx-2.5
Sequence:
MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALGKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEKPGAADSDPEPERTGEERSAAPLGRSPSRDASPARLTEPERSRERRSPERCSKEPTEGGGDGPFSLRSLEKERPEARRKDEGRKDVGEGKEPSLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAEGSKGGNSREPSPLPELALRKVGGPSRGALSPSGSAKEAASELQSIQRLVSGLESQRALSPGRESPK
Protein: Syntaxin, Qa-SNARE family (Q8I4Z9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Vacuolar protein sorting-associated protein 45
- Alpha-soluble NSF attachment protein, putative
- SNARE protein, putative
- Syntaxin-6, putative
- SNARE protein, putative
- Vesicle transport v-SNARE protein VTI1, putative
- Vesicle transport v-SNARE protein, putative
- SNARE protein
- Syntaxin, Qa-SNARE family
- Syntaxin, Qa-SNARE family
Sequence:
MEVIYRNITNTYFDYRREIKKKKNRFKLRAYEKLDEDEDTGKENLLNENEDLEMQEQSMLPPYWIEKIEECSEDINNMKTKLIQLQKLQKNKLLNALNNDETLTENITQLSSNITFLIKNCEQKIQSVSSKDYDKDKNNIIEKLKNNAKSSLLSQLQSLSQTFHKNQKSYIKEFKKMSNAYDDLQQYQNFNEQNELLYQQEEQQHSSVNMNKRNSDLKKIADTVVDLHTIFKELSVMLVDQGSLLDQIDYNMEASLDKSEKGINKLKIIEKRENDKIAKKCVSYLTTLIFVLLFLIIIKHLY
Protein: Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor) (P34995)
Organism: Homo sapiens (Human)
Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prostaglandin E2 receptor EP4 subtype
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Prostaglandin G/H synthase 2
- Guanine nucleotide-binding protein subunit alpha-15
- Prostaglandin E synthase
- Prostaglandin G/H synthase 1
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
Protein: rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2) (Q9CPY0)
Organism: Mus musculus (Mouse)
Function: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24036117}.
Interaction partners:
- Mitochondrial ribosome-associated GTPase 2
- rRNA methyltransferase 1, mitochondrial
- Mitochondrial ribosome-associated GTPase 1
- 5-cytosine rRNA methyltransferase NSUN4
- Mitochondrial assembly of ribosomal large subunit protein 1
- GTP-binding protein 4
- Transcription termination factor 4, mitochondrial
- rRNA methyltransferase 3, mitochondrial
- tRNA
- Pescadillo homolog
Sequence:
MAGHLKLVGVPLKVRRLHTAVCHYRGRTGAEHLWLTRHLKDPFVKAAKVESYRCRSAFKLLEMNEKHQILRPGLRVLDCGAAPGAWSQVAVQRVNATGADSSSPVGFVLGVDLLHIFPLAGATFLCPADVTDPRTFQKILELLPSRRADVILSDMAPNATGIRDLDHDKLISLCLTLVDMAVDILHPGGTLLCKTWAGSKSHLLQKRLTQEFQSTRVVKPEASRKESSEVYLLATQYRGGKGTRRP
Protein: Uncharacterized protein (Q387H8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MELMEERPEMNRSVSADENGEDPAVASGADIPAHVMRRILSARAFRENARRIDDVTSFVSRAVKTLSDKEGVSLHSDALALLENISREEDHIFSKIPDDMREVLDKKKAVVTFSKRKANGKRDAGVEVSTEHSPRRDHGTIIRFTIDPNTPLPMPHNPVLGSLDPKKQTNGHYHELFFGDRDAIVFQPPENNKRKELEKRRKEKLYWENKMKRPAKEIKLETGKVLKVPKDFVPACAEVDHSAEQEKLQLKKSVDSERNLIIFR
Protein: PrgO (ParB) (PrgO protein) (PrgO-like protein for plasmid replication) (Type III secretion system protein PrgO) (A1JV32)
Organism: Enterococcus faecium (Streptococcus faecium)
Interaction partners:
Sequence:
MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDPPVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD
Protein: Beta-D-glucopyranosyl abscisate beta-glucosidase (EC 3.2.1.175) (Beta-glucosidase 1) (AtBG1) (Beta-glucosidase 18) (AtBGLU18) (Beta-glucosidase homolog 1) (Q9SE50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes abscisic acid glucose ester (ABA-GE) which represents the predominant form of conjugated ABA (biologically inactive). No activity with beta-D-glucopyranosyl zeatin. The hydrolysis of ABA-GE in the endoplasmic reticulum (ER) forms free ABA and contributes to increase its cellular levels under dehydration conditions. ABA-GE hydrolyzing activity is enhanced by dehydration stress-induced polymerization into higher molecular weight forms. The ABA produced by BGLU18 contributes to the initiation of intracellular signaling as well as the increase in the extracellular ABA level.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:19147648, ECO:0000269|PubMed:19847124}. Note=Located in ER bodies.
Interaction partners:
- Abscisic-aldehyde oxidase
- Abscisic acid 8'-hydroxylase 3
- Abscisic acid 8'-hydroxylase 1
- Abscisic acid 8'-hydroxylase 4
- Abscisic acid 8'-hydroxylase 2
- TSA1-like protein
- Jacalin-related lectin 35
- TSK-associating protein 1
- Transcription factor NAI1
- Glucan endo-1,3-beta-glucosidase, acidic isoform
Sequence:
MVRFEKVHLVLGLALVLTLVGAPTKAQGPVCGAGLPDKFSRLNFPEGFIWGTATAAFQVEGAVNEGCRGPSMWDTFTKKFPHRCENHNADVAVDFYHRYKEDIQLMKDLNTDAFRLSIAWPRIFPHGRMSKGISKVGVQFYHDLIDELLKNNIIPLVTVFHWDTPQDLEDEYGGFLSGRIVQDFTEYANFTFHEYGHKVKHWITFNEPWVFSRAGYDNGKKAPGRCSPYIPGYGQHCQDGRSGYEAYQVSHNLLLSHAYAVDAFRNCKQCAGGKIGIAHSPAWFEPQDLEHVGGSIERVLDFILGWHLAPTTYGDYPQSMKDRVGHRLPKFTEAEKKLLKGSTDYVGMNYYTSVFAKEISPDPKSPSWTTDSLVDWDSKSVDGYKIGSKPFNGKLDVYSKGLRYLLKYIKDNYGDPEVIIAENGYGEDLGEKHNDVNFGTQDHNRKYYIQRHLLSMHDAICKDKVNVTGYFVWSLMDNFEWQDGYKARFGLYYIDFQNNLTRHQKVSGKWYSEFLKPQFPTSKLREEL
Protein: Iron-sulfur assembly protein 2 (O43045)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Iron-sulfur assembly protein 1
- Iron sulfur cluster assembly protein 1, mitochondrial
- Iron-sulfur cluster assembly factor IBA57
- NifU-like protein C1709.19c
- Monothiol glutaredoxin-5
- GrpE protein homolog
- Probable cysteine desulfurase, mitochondrial
- Frataxin homolog, mitochondrial
- Protein isd11
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
Sequence:
MLMKSRVNLLFKGPFFFRERCFQTLLNPVIAIRQLSHGSLRNSRSCRIDAKSNTLTKEIFPKINNEFKIKNRFYSSKLANDQFTLQEQCDEKGIPFILYVKDSAKKQLEKIAERKPEENSVLRVTVDGGGCHGYQVSFRMDNKIGNADTVFVRGKARVVADNISLPLISGSEIEYTNELIGSSFQLLNNPRAKTSCGCNVSFDVE
Protein: Dystrobrevin binding protein 1 isoform 1 (A0A0S2Z5U8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00037838}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037838}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037838}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004125}. Melanosome membrane {ECO:0000256|ARBA:ARBA00037798}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037798}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037798}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}.
Interaction partners:
Sequence:
MLETLRERLLSVQQDFTSGLKTLSDKSREAKVKSKPRTVPFLPKYSAGLELLSRYEDTWAALHRRAKDCASAGELVDSEVVMLSAHWEKKKTSLVELQEQLQQLPALIADLESMTANLTHLEASFEEVENNLLHLEDLCGQCELERCKHMQSQQLENYKKNKRKELETFKAELDAEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDVFLNSGGEENTVLSPALGPESSTCQNEITLQVPNPSELRAKPPSSSSTCTDSATRDISEGGESPVVQSDEEEVQVDTALATSHTDREATPDGGEDSDS
Protein: G-protein coupled receptor 3 (G-protein-coupled receptor R4) (Q8K1Q3)
Organism: Rattus norvegicus (Rat)
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth. Maintains also meiotic arrest in oocytes (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Beta-arrestin-2
- N-arachidonyl glycine receptor
- G protein-coupled receptor 55
Sequence:
MMWGAGRSMAWFSAGSGSVNVSIDPAEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAADFCIGSPEMSLVLVGVLATAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCRDGLTTCGVVYPLSKNHLVVLAIVFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDANSPPLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSPSDV