wanglab/gogpt-training-data huggingface dataset:
Protein: RNA-binding Fox protein 1, isoform I (A8JNQ4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MYYPHMVQAGVAPFPGAPAGYAAAPNPGAAVVAAAAAAQQQQQQQQQQQQQQQQAQQQQQQQVAGGPPSAADSLSMAVAAAAAKQSADPVTQMKSGSEAAGSGNSNNNNTAGAGTGAPGAAGGLTTEYSSGGCGGGGASTANSVVVATSVSDVVNASLYMQQKTNLSTQTQTQYEYEYEYNGTSLAEPRVPGPIPHPLTNGHAVDQVQQPPVQQQHLQSSLPPQNVLSISTVLIANEAAESQQSSAMQNAGGGGNTGGGGGGGGGGTPSSPLSNSPSSATASQAGGCGLTLNGSATEGSMSGDTSPVASGEPLLQTPPAHQQQQQQQQPLLCSSPTSMQSSGTSVTGSSIASGTLAATSSSGVGLLPTTGLDSIANGGAPTGCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSLSSALVPAQSVAAVAAASLDAKSQPKRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVVEGRKIEVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEGYRLPVAAWPFLGAPVGAGAPTLTHLQLPVSMQMAQAPSAVAGGTAATSPATAAAAAAHAAAAAAATPIMLAPRPPHTAVQAATPTAATPRRSVYYDPFLAAAASADPNLRFQAAKPVTEVPAAQPAAILNRRTVTTLNSNPHTINRIPVPQNVLATAPLLKTPLSQAQQQAYATAATTYTAVAARAAYGAAAAAAAQPALAGYATVAGYAREYADPYLGHGIGPVPGYGATMYRGGFNRFTPY
Protein: PRO0813 (Solute carrier family 16 member 10) (Q9P1I2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII
Protein: Amastin (Q585K0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCCGWLTTLVTLFAVASAVCALVFPVFRMKNETKEAIQTLWYYMEKVDDVVKQTKVHESPCKEYSVYFQVIEAGVLISVLTGFAALVFIILSNCKIPLCCLRIISTPLSIISFLVSSVSAVLITVGYGKGFCQWDDQLREDFAPFKERDFSVDAGFYLIVVTAVLFLVSSVAGCCL
Protein: Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Mannanase 26A) (Man26A) (Mannanase A) (ManA) (P49424)
Organism: Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Function: Catalyzes the endo hydrolysis of beta-1,4-linked mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall. Preferentially hydrolyzes the larger oligosaccharides and has greater activity against non-substituted polysaccharides. It displays tight specificity for mannose at both the -2 and the -1 subsites. Appears to act in synergy with alpha-galactosidase (AgaA) to elicit hydrolysis of galactomannan.
Interaction partners:
- Putative 1,4-beta mannosidase man5D
- Endo-1, 4-beta mannanase, man5C
- Endo-1, 4-beta mannanase, putative, man26C
- Endo-1, 4-beta mannanase, man26B
- Mannan endo-1,4-beta-mannosidase
- Endo-beta-mannanase, putative, man5E
- Endoglucanase
- Probable NAGC-like transcription regulator yajF
- 4-O-beta-D-mannosyl-D-glucose phosphorylase
- Cellobiose 2-epimerase
Sequence:
MKTITTARLPWAAQSFALGICLIALLGCNHAANKSSASRADVKPVTVKLVDSQATMETRSLFAFMQEQRRHSIMFGHQHETTQGLTITRTDGTQSDTFNAVGDFAAVYGWDTLSIVAPKAEGDIVAQVKKAYARGGIITVSSHFDNPKTDTQKGVWPVGTSWDQTPAVVDSLPGGAYNPVLNGYLDQVAEWANNLKDEQGRLIPVIFRLYHENTGSWFWWGDKQSTPEQYKQLFRYSVEYLRDVKGVRNFLYAYSPNNFWDVTEANYLERYPGDEWVDVLGFDTYGPVADNADWFRNVVANAALVARMAEARGKIPVISEIGIRAPDIEAGLYDNQWYRKLISGLKADPDAREIAFLLVWRNAPQGVPGPNGTQVPHYWVPANRPENINNGTLEDFQAFYADEFTAFNRDIEQVYQRPTLIVK
Protein: EH-domain containing protein (F6M3L0)
Organism: Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004125}.
Interaction partners:
Sequence:
MFSWSNKDATDGKNPEMFQTVSGGLKKLYRTRLLPLEEHYSFHSFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGIRIGPEPTTDSFIAVMHGDTEGTIPGNALVVDPKKPFRKLNAFGNSFLNRFMCAQMPNPVLESISIIDTPGILSGEKQRLSRGYDFTAVLMWFAERVDRIILLFDAHKLDISDEFSEVIRALKGHDDKIRVVLNKADQVETQQLMRVYGALMWSLGKVINTPEVVRVYMGSFWSNPLLIPDNRRLFEMEEQDLFKDIQTLPRNAALRKLNDLIKRTRLAKVHAYIISHLRKEMPAVFGKEAKKKELIANLGEIYTRIEREHQISAGDFPNLKKMQDQLQDQDFSKFHTLKPKLFEKVDEMLSQDIARLMGLVRQEEARVPSQAVRGGAFEGTENGPFGRGYGEGAGEGADEADWVVSKDKPAYDEIFYTLSXIDGKISGASAKREMVKSKLPNTVLGRIWKLADVDKDGMLDDDEFALANHLIKVKLEGHELPEELPLHLLPPSKRKLAMAE
Protein: Histone deacetylase 6 (A0A0G2QC41)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- RCG31562, isoform CRA_c.
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- E3 ubiquitin-protein ligase parkin
- Ataxin-3
- NAD-dependent protein deacetylase sirtuin-2
- Transitional endoplasmic reticulum ATPase
- Sequestosome-1
- Histone deacetylase 11
- Alpha-tubulin N-acetyltransferase 1
Sequence:
MTSTGQDSSTRQRKSRHNPQSPLQDSSATLKRGGKKGAVPHSSPNLAEVKKKGKMKKLSQPAEEDLIVGLQGLDLNSETRVPVGTGLVFDEQLNDFHCLWDDSFPENPERLHAIKEQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAGTYDSVYLHPNSYSCACLATGSVLRLVDAVMGAEIRNGMAVIRPPGHHAQRSLMDGYCMFNHLAVAARYAQKKHRIQRILIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHILLPVAFEFQPQLVLVAAGFDALHGDPKVRQGEMSATPAGFAHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGDPCPMLESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLEDEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTPCYLGNRYVERLRATEKMKTRDLHREGANFESIYICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQVIAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSLRPPQSGALASISEVIQVHRKYWRSLRLMKMEDKEERSSSRLVIKKLPQSASPVSAKGMTTPKGKVLEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTDQCASVAATENSANQTTSGEEASGETESFGTSPSSNASKQTTGASPLHGAAAQQSPELGLSSTLELSSEAQEVQESEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGSVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYLCQAYVHHEDLQDVKNAAHQNKFGEGMPHLQ
Protein: 2-amino-4-deoxychorismate synthase (ADIC synthase) (EC 2.6.1.86) (Q8GMH4)
Organism: Streptomyces globisporus
Function: Converts chorismate to 2-amino-4-deoxychorismate (ADIC). Involved in the biosynthesis of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
Interaction partners:
Sequence:
MTDQCVVSAPVRVRTRRLDVKETGALPAYRALAEHFGPDEVYLLESAAGPARDRRHQFVGFGALLSLSVTDRVVRVEGVPALRGLLLERAGALLEDGPQGLRLRTAGGLWPLLRAMRDMFDAEGSASGFRFGFLGFFGYDTARYIEDLPHLIENRPGLPDVRMVLHRGSVVTDLATGRCELLLHESPYWPGLAPETVTGLLADVEQAWPDPSADGFPASAVTDDSAPEVFANDVERCLKHIAVGDIYQVQIGHELSIRSTADPADVYQRLRGRNASPYMYLAGIDGHRLIGASPELFVRIEDGEVTMRPIAGTVPRSGADGGIAAGVRLRSDPKEIAEHTMLVDLCRNDIGRIARPNTLDVPDQLDVEGYSHVLHLVSTVVGRARVDTDAFDTIAALFPAGTMTGAPKIRAMEIIESVERSRRGLYAGALGLLDVGGYTNLALCIRTLFHHEGVYRTRASAGIVADSEPGAEWTETLAKMSATHWAVTGEELL
Protein: Rac-like GTP-binding protein ARAC4 (AtRAC4) (GTPase protein ROP2) (Q38919)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation (By similarity). Involved in cell polarity control during the actin-dependent tip growth of root hairs, thus regulating root hair length and root hair initiation. May regulate a WAVE complex that activates the Arp2/3 complex.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q38937}. Cell membrane {ECO:0000269|PubMed:27251533, ECO:0000269|PubMed:30770391}; Peripheral membrane protein {ECO:0000255}. Note=Associated with the membrane when activated. The localization to the plasma membrane requires YIP4A and YIP4B (PubMed:30770391). Accumulates in a sterol-enriched, polar membrane domain during root hair initiation (PubMed:27251533). {ECO:0000269|PubMed:27251533, ECO:0000269|PubMed:30770391}.
Interaction partners:
- Guanine nucleotide exchange factor SPIKE 1
- CRIB domain-containing protein RIC4
- Rho GDP-dissociation inhibitor 1
- Auxin-binding protein 1
- CRIB domain-containing protein RIC1
- Respiratory burst oxidase homolog protein C
- Interactor of constitutive active ROPs 1
- Actin-related protein 2
- GPI-anchored protein LLG1
- KOW domain-containing protein
Sequence:
MASRFIKCVTVGDGAVGKTCMLISYTSNTFPTDYVPTVFDNFSANVVVDGNTVNLGLWDTAGQEDYNRLRPLSYRGADVFILAFSLISKASYENIAKKWIPELRHYAPGVPIILVGTKLDLRDDKQFFIDHPGAVPITTNQGEELKKLIGSAVYIECSSKTQQNVKAVFDAAIKVVLQPPKQKKKKKNKNRCAFL
Protein: Similar to palladin CGI-151 protein (Q5M7W2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSETSSHDSFYDSLSDVQEEGRSADFFPGLSAFLSQEEINKSLDLARRAIDNSETEDFDSEKEISQIFSKSPTSLCETPSYEEKKSGEQTSSEGPRDNRRASVQPLAEQAERITSPAASKRKPGVSPLLASPSYIRSLRKAEKRGAKVPNPSAKPKAAQQSKTGPQSQLCDKAASFIEELTSIFREAAKPRNRSPNGESSSPDSGYLSPKNQPSTLMSASASQSPTADQLDQLEMDAEVKQPQGSLCYQAHKAPEETLPHTHIPHPQPQKARHLPSSAPRFIQKLRSQEVAEGSRVYLECRVTGNPAPRVSSLCSGQTKLLCL
Protein: Heat shock protein 70 (Q8II24)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- GrpE protein homolog
- Mitochondrial import inner membrane translocase subunit TIM44, putative
- Heat shock protein 60
- DnaJ protein, putative
- 60 kDa chaperonin
- Cytochrome c oxidase subunit 5B, putative
- Mitochondrial import inner membrane translocase subunit TIM17, putative
- Mitochondrial import inner membrane translocase subunit TIM14, putative
- Mitochondrial import inner membrane translocase subunit TIM23, putative
- Iron-sulfur cluster assembly protein IscU
Sequence:
MASLNKKNIVKILERCVKNTLLSEKSRSLCTSKINRNRASGDIIGIDLGTTNSCVAIMEGKQGKVIENSEGFRTTPSVVAFTNDNQRLVGIVAKRQAITNPENTVYATKRFIGRKYDEDATKKEQKNLPYKIVRASNGDAWIEAQGKKYSPSQIGACVLEKMKETAENYLGRKVHQAVITVPAYFNDSQRQATKDAGKIAGLDVLRIINEPTAAALAFGLEKSDGKVIAVYDLGGGTFDISILEILSGVFEVKATNGNTSLGGEDFDQRILEYFISEFKKKENIDLKNDKLALQRLREAAETAKIELSSKTQTEINLPFITANQTGPKHLQIKLTRAKLEELCHDLLKGTIEPCEKCIKDADVKKEEINEIILVGGMTRMPKVTDTVKQIFQNNPSKGVNPDEAVALGAAIQGGVLKGEIKDLLLLDVIPLSLGIETLGGVFTKLINRNTTIPTKKSQIFSTAADNQTQVSIKVFQGEREMASDNKLLGSFDLVGIPPAPRGVPQIEVTFDVDANAIINISAIDKMTNKKQQITIQSSGGLSKEEIEKMVQEAELNREKDQLKKNLTDSKNEAETLIYSSEKQLEDFKDKISDSDKDELRQKITVLREKLTSEDLDSIKDATKQLQEKSWAISQEMYKNNAQQGAQQEQPNNENKAEENKDNA
Protein: Oxysterol binding protein like 9 (E9PNR1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFS
Protein: Interleukin-6 (IL-6) (P29455)
Organism: Ovis aries (Sheep)
Function: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05231}.
Interaction partners:
- Interleukin-6 receptor subunit alpha
- Interleukin-10
- T-cell surface glycoprotein CD4
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Toll-like receptor 4
- Interleukin-6 receptor subunit beta
- Signal transducer and activator of transcription
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-5
Sequence:
MNSLFTSAFSPLAVSLGLLLVMTSAFPTPGPLGEDFKNDTTPSRLLLTTPEKTEALIKHIVDKISAIRKEICEKNDECENSKETLAENKLKLPKMEEKDGCFQSGFNQAICLIKTTAGLLEYQIYLDFLQNEFEGNQETVMELQSSIRTLIQILKEKIAGLITTPATHTDMLEKMQSSNEWVKNAKVIIILRSLENFLQFSLRAIRMK
Protein: Atypical kinase COQ8, mitochondrial (EC 2.7.-.-) (Activity of bc1 complex protein 1) (Coenzyme Q protein 8) (Ubiquinone biosynthesis protein coq8) (Q92338)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24911838}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis protein coq9
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- 5-demethoxyubiquinone hydroxylase, mitochondrial
- Ubiquinone biosynthesis protein coq4, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Ubiquinone biosynthesis protein coq11
- Decaprenyl-diphosphate synthase subunit 2
- ATP synthase subunit beta, mitochondrial
Sequence:
MANSGLWELITIGSAVRNVAKSYLKAEASSITAKQLYDASKITSSKRSTSDLHVQLLEKYRNGKVKHASQIKELGLSSKDTKRTLLGNSLDVQKDASGVKHLQEQSSKEIKNPISQPILPNKKDEISPAKPSAIDSSIKDVTKSHPATNANFTADFESSIEESYSTENKSPVILSSSKVPSSQWSRLWHYGGLATSLSVGAIGEKMKRMWGISKDDGALLLNERNVEILVNKLTQMRGAALKMGQMLSFQDSKLIDPRVSQILERVRDGAHSMPEKQLEQVMVKNLGKNWMTHYSEFDRKPMAAASIGQVHRARLASNHMEVVVKVQYPGVMSSIDSDLNNLAYLLKASRILPKGLFLENSLAAARKELKWECDYEREAAFAERFGSLLKNDSDFKVPMVFREASGPSVITLEYLHGIALGKQKYSQATRNHIGYLLTKQCLREISEYHFMQTDPNWSNFLYNGKTKKIELLDFGASIEYDEKFIKKYCRLLLAAAHRNREKCKKLSVELGYLNNHESAQMIDAHINSIFTLAEPFAFDAPDVYDFGDQTITARVKQQIPVMLDLRLQPPPEETYSLHRRLSGHFLLCAKLGAKVRCKELFSGMLKHYAD
Protein: ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (Q6MG08)
Organism: Rattus norvegicus (Rat)
Function: Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8NE71}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8NE71}. Nucleus envelope {ECO:0000250|UniProtKB:Q8NE71}.
Interaction partners:
- Large ribosomal subunit protein uL5
- Stalled ribosome sensor GCN1
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein uS14
- ATP-binding cassette sub-family E member 1
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL19
- Elongation factor 2
Sequence:
MPKGPKQQPPEPEWIGDGEGTSPADKVVKKGKKDKKTKKTFFEELAVEDKQAGEEEKLQKEKEQQQQQQQQKKKRDTRKGRRKKDVDDDDDGDERVLMERLKQLSVPASDEEDEVPVPVPRGRKKAKGGNVFEALIQDESEEEKEEEEEKPVLKPAKPEKNRINKAVAEEPPGLRNKKGKEEKSKGKAKNKPSATDSEGEDDEDMTKEKEPPRPGKDKDKKGAEQGSEEEKEEKEGEVKANDPYAHLSKKEKKKLKKQMDYERQVESLKAANAAENDFSVSQAEVSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLRLLEEEKRLQGQLEQGDDTAAEKLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDTQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEVLTRKQQKCRRKNQDEESQDPPELLKRPREYTVRFTFPDPPPLSPPVLGLHGVTFGYEGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTNGEMRKNHRLKIGFFNQQYAEQLHMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFDDYKREVLEALGEVMVNRPRD
Protein: Large ribosomal subunit protein eL27 (60S ribosomal protein L27) (Q9P843)
Organism: Candida albicans (Yeast)
Interaction partners:
Sequence:
MAKFIKSGKVAIVVRGRYAGKKVVIVKPHDEGTKSHPFPHAIVAGIERAPLKVTKKMDAKKVTKRTKVKPFVKLVNYNHLMPTRYSLDVESFKSAVTSEALEEPSQREEAKKVVKKAFEEKHQAGKNKWFFQKLHF
Protein: diguanylate cyclase (EC 2.7.7.65) (Q9HW69)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- cyclic-guanylate-specific phosphodiesterase
- Cyclic di-GMP phosphodiesterase RocR
- EAL domain-containing protein
- FimX
- Cyclic di-GMP phosphodiesterase PA2567
- cyclic-guanylate-specific phosphodiesterase
- cyclic-guanylate-specific phosphodiesterase
- Probable ferredoxin reductase
- GGDEF domain-containing protein
- cyclic-guanylate-specific phosphodiesterase
Sequence:
MNCRASATLWIRSSCLITAMEHGPLQAGNSDAGQGHGAGRSRGARRSGTGAKKARQYSRSGETGARADDQTLVGQPAGRPINPRSASWQFVRLGNPQGAGYIAARCHYGTEPMRTDKPPLKQRALQKLLLRRFGMAAGTYLLGLVLLWLALLSGFYRAAPTTAAASTTLVVACQLAFLWLFASGRNLRYADPSLTEPQVLVAIAWLTYFLYHVDSLRGTFMVFYVLALLFGVFQLPPRVFARCAALAFIAFSGIYLVEALQQRLELPGRAALQVLVMFIVMVWLSLFASYIQAMRQRMRQRRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFMRMASRALEDLLPNRQHGLALIDLDHFKRINDRHGHAAGDRVLQTFAAVARSCLRDGDVLARYGGEEFVLLLPHADAEQLESCCERLRLAFQQAEPVGVTVDTLSLSVGMTLLYADDDLDEALQRADQALYRAKRGGRNRCDATWEVTSA
Protein: Type 3 secretion system translocon protein SctB (T3SS translocon protein SctB) (Protein EaeB) (Q05129)
Organism: Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Function: Required for the intimate attachment of E.coli to the epithelial cells. Probable aminotransferase.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9R803}. Cell surface {ECO:0000250|UniProtKB:Q9R803}. Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Note=Secreted via the type III secretion system (SPI-2 T3SS). {ECO:0000250|UniProtKB:Q9R803}.
Interaction partners:
Sequence:
MNTIDNNNAAIAVNSVLSSTTDSTSSTTTSTSSISSSLLTDGRVDISKLLLEVQKLLREMVTTLQDYLQKQLAQSYDIQKAVFESQNKAIDEKKAGATAALIGGAISSVLGILGSFAAINSATKGASDVAQQAASTSAKSIGTVSEASTKALAKASEGIADAADDAAGAMQQTIATAAKAASRTSGITDDVATSAQKASQVAEEAADAAQELAQKAGLLSRFTAAAGRISGSTPFIVVTSLAEGTKTLPTTISESVKSNHDINEQRAKSVENLQASNLDTYKQDVRRAQDDISSRLRDMTTTARDLTDLINRMGQAARLAG
Protein: cDNA: FLJ22558 fis, clone HSI01557 (Q9H669)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGAQSGPLPQTEPWPLKVDSEAAAPPAASVSSQARSGKGFKSKPPGSCVRSTQQGFKVSNWFGTQPGPPKETKAGTGWGQAGLAGSCADPPRVPWEAVGLAVAAVSCSQASPASPGSGRRASAHFISHRLRRPGAPPSTHNKERDSFRTAFIWITD
Protein: Biopolymer transport protein ExbB (P0ABU7)
Organism: Escherichia coli (strain K12)
Function: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Protein TonB
- Biopolymer transport protein ExbD
- Ferrichrome outer membrane transporter/phage receptor
- Ferrienterobactin receptor
- Tol-Pal system protein TolR
- Vitamin B12 transporter BtuB
- Catecholate siderophore receptor Fiu
- Fe
- Hydroxamate siderophore receptor FhuE
- Ferric siderophore reductase
Sequence:
MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQLLAEARSLNQANDIAADFGSKSLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVAAVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQKLRAG
Protein: Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) (Q9BZE9)
Organism: Homo sapiens (Human)
Function: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:22207755}; Peripheral membrane protein. Cytoplasm {ECO:0000269|PubMed:23349634}. Nucleus {ECO:0000269|PubMed:23349634}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- NSFL1 cofactor p47
- UBX domain-containing protein 7
- UBX domain-containing protein 2A
- Nuclear protein localization protein 4 homolog
- UBX domain-containing protein 2B
- UBX domain-containing protein 6
- UBX domain-containing protein 10
- FAS-associated factor 1
- Transcription factor E3
Sequence:
MAAPAGGGGSAVSVLAPNGRRHTVKVTPSTVLLQVLEDTCRRQDFNPCEYDLKFQRSVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQDSFCSGQTLWELLSHFPQIRECLQHPGGATPVCVYTRDEVTGEAALRGTTLQSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGELSRGDLSRPEDADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPPGPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQEQERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGKVPKWLKLPASKR
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-alpha-3) (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Q60996)
Organism: Mus musculus (Mouse)
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}.
Interaction partners:
- Shugoshin 1
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Apoptosis regulator Bcl-2
- Meiotic recombination protein REC8 homolog
- D
Sequence:
MLTCNKAGSGMVVDAASSNGPFQPVALLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEAVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYAVYSQASAVSIPVAMETDGPQFEDVQMLKKTVSDEARQAQKELKKDRPLVRRKSELPQDPHTEKALEAHCRASELLSQDGR
Protein: Phosphatidylinositol transfer protein cytoplasmic 1 (A0A0C4DGP0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDDVREYEKNMHEQTNIKVCNQHSSPVDDIESHAQTST
Protein: Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) (P00505)
Organism: Homo sapiens (Human)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane. {ECO:0000269|PubMed:9537447}.
Interaction partners:
- Malate dehydrogenase, mitochondrial
- Kynurenine--oxoglutarate transaminase 3
- Tyrosine aminotransferase
- Aspartate aminotransferase, cytoplasmic
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Kynurenine--oxoglutarate transaminase 1
- Glutamate dehydrogenase 1, mitochondrial
- Fumarate hydratase, mitochondrial
- Alanine aminotransferase 1
- Alanine aminotransferase 2
Sequence:
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGMRTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGYLAHAIHQVTK