wanglab/gogpt-training-data huggingface dataset:
Protein: Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog) (Q8VBT9)
Organism: Mus musculus (Mouse)
Function: Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:14562105}; Peripheral membrane protein {ECO:0000269|PubMed:14562105}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9BZE9}; Peripheral membrane protein. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- UBX domain-containing protein 7
- Nuclear protein localization protein 4 homolog
- NSFL1 cofactor p47
- UBX domain-containing protein 2B
- UBX domain-containing protein 2A
- UBX domain-containing protein 10
- UBX domain-containing protein 6
- Transitional endoplasmic reticulum ATPase
- FAS-associated factor 1
- Solute carrier family 2, facilitated glucose transporter member 4
Sequence:
MAAPAGGGGSAVSVLAPNGRRHTVKVTPSTVLLQVLEDTCRRQDFNPSEYDLKFQRTVLDLSLQWRFANLPNNAKLEMVPVSRSREGPENIVRIAFQLDDGSRLQDAFCSRQTLWELLSHFAQTRERLQQLGEKTPVCVYMRNEVTGRAALQNTTLQSLGLTGGSATIRFVIKQCDTAGKQESIAVRSKAPGSPVSSLSADQASSSTLLPLNSGEFSRGDLNHEGDANTSGTGLEGGPKPTDAQTKQSTSEPASAPFVPFSGGGQRLGGPSASLRPLTSPSANSSKSFSGPGGPSKPKKPKPGEEPQQEPEPPVDRDPVVYHPDLEDLLQPWPAEVPDEFFEVTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQMKEKLERYPKVALRVLFPDRYILQGFFRPSETVGDLRDFVRSHLGNPELSFYLFIAPPKMVLDDHTLTLFQANLFPAALVHFGAEEPTGLYLEPGLLEHTVSPSTADVLVARCMSRASGSPPLLPAPDPVSLESEPIAEDGALGPPEPIQGTAQPVKRSLGKVPKWLKLPASKR
Protein: Cytochrome b-c1 complex subunit Rieske-1, mitochondrial (EC 7.1.1.8) (Complex III subunit 5-1) (Rieske iron-sulfur protein 1) (RISP1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit 1) (Q94JS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11870776, ECO:0000269|PubMed:12606038, ECO:0000269|PubMed:18189341}; Single-pass membrane protein {ECO:0000250|UniProtKB:P08067}.
Interaction partners:
- Cytochrome b-c1 complex subunit 6-1, mitochondrial
- Cytochrome b-c1 complex subunit 7-2, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c1 2, heme protein, mitochondrial
- Cytochrome c1 1, heme protein, mitochondrial
- Probable mitochondrial-processing peptidase subunit beta, mitochondrial
- Cytochrome b-c1 complex subunit 7-1, mitochondrial
- Cytochrome b-c1 complex subunit 6-2, mitochondrial
- Cytochrome b
- Cytochrome b
Sequence:
MLRVAGRRLFSVSQRSSTATSFVVSRDHTLSDGGGDSSSAPRSLPSADLSSYHRSLIRGFSSQVLAQGNEIGFGSEVPATVEAVKTPNSKIVYDDHNHERYPPGDPSKRAFAYFVLSGGRFVYASVLRLLVLKLIVSMSASKDVLALASLEVDLGSIEPGTTVTVKWRGKPVFIRRRTEDDIKLANSVDVGSLRDPQEDSVRVKNPEWLVVVGVCTHLGCIPLPNAGDYGGWFCPCHGSHYDISGRIRKGPAPYNLEVPTYSFLEENKLLIG
Protein: Glucokinase (EC 2.7.1.2) (Q4Q1I9)
Organism: Leishmania major
Interaction partners:
- Phosphotransferase
- Phosphotransferase
- Aldose 1-epimerase-like protein
- Glucose-6-phosphate isomerase
- Phosphomannomutase-like protein
- Aldose 1-epimerase-like protein
- glucose-6-phosphate 1-epimerase
- Putative aldose 1-epimerase
- phosphoglucomutase
- Transaldolase
Sequence:
MPLTDEIQLEQLAPTIKGDASWSTGPIYVVCDVGGTNARVGFARAAQHEGSGLHIIYVRFRVTKRDIRQLLEFFDEVLQHLKKNLPYRAGPFLRRVASGAVSVPGPLTNGQLAGPFSNLKGIARLADYPVELFPRGRSALLNDLEAGSYGVLALSNAGMLSDYFKVMWKGTQWDALSEGKPVGSTIGHGRCMVVAPGTGVGSSLIHYVGVSDSYVVLALECGCLSMSWCANEDSKYVQALAGYMASKARVKGLDSTVAPIWEAAANGSGLEFNYAYEKEGPKASAPLKSAPEVAKLAKAGSDPAAVAAMDRLYKNLIGLTAETTMQFLPLTCVLMGDSIVSNSFYFDNPENVKKLQARINEHTMERQLKFLSRTTFLRQVRSVNINLLGCLEFGSQLSNRADQLAPTKSNL
Protein: Kynurenine--oxoglutarate transaminase 1 (Kynurenine--oxoglutarate transaminase I) (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (KATI) (Q08415)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Subcellular location: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:7796908, ECO:0000269|PubMed:8502223}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:7796908}.
Interaction partners:
- Kynureninase
- Kynurenine 3-monooxygenase
- Kynurenine formamidase
- Aspartate aminotransferase, mitochondrial
- Cystathionine gamma-lyase
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Cystathionine beta-synthase
- Adenosylhomocysteinase
- Betaine--homocysteine S-methyltransferase 1
Sequence:
MTKRLQARRLDGIDQNLWVEFGKLTKEYDVVNLGQGFPDFSPPDFATQAFQQATSGNFMLNQYTRAFGYPPLTNVLASFFGKLLGQEMDPLTNVLVTVGAYGALFTRFQALVDEGDEVIIMEPAFDCYEPMTMMAGGCPVFVTLKPSPAPKGKLGASNDWQLDPAELASKFTPRTKILVLNTPNNPLGKVFSRMELELVANLCQQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTIGSAGKSFSATGWKVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMELNRDHMIRSLQSVGLKLWISQGSYFLIADISDFKSKMPDLPGAEDEPYDRRFAKWMIKNMGLVGIPVSTFFSRPHQKDFDHYIRFCFVKDKATLQAMDERLRKWKELQP
Protein: Calcium/calmodulin dependent protein kinase I (Calcium/calmodulin-dependent protein kinase I, isoform A) (Calcium/calmodulin-dependent protein kinase I, isoform B (EC 2.7.11.17)) (Calcium/calmodulin-dependent protein kinase I, isoform G) (RE39750p) (Q7JMV3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- AT10229p
- Calmodulin
- Calcium-binding protein E63-1
- FI14603p
- EF-hand domain-containing protein
- Calmodulin-related protein 97A
- EF-hand domain-containing protein
- GEO12020p1
- MIP05401p
- AT16150p
Sequence:
MPLFGKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNKSGGSTNAASQ
Protein: Large ribosomal subunit protein uL1B (60S ribosomal protein L1-B) (L10a) (P0CX44)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY
Protein: Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (Q8BKZ9)
Organism: Mus musculus (Mouse)
Function: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Dihydrolipoyl dehydrogenase, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- [Pyruvate dehydrogenase
- [Pyruvate dehydrogenase
Sequence:
MAASWRLHCNQPLLRYLLGFSSRRSLGLAQGAAAWPVDRGASWRWFHSTQLLQADPIKVLMPSLSPTMEQGNIVKWLRKEGEAVSAGDSLCEIETDKAVVTLDANDDGILAKIVVEEGAKNIQLGSLIALMVEEGEDWKQVEIPKDVSAPPPVSKPPAPTQPSPQPQIPCPARKEHKGTARFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVELKQMGKITESRPASAPPPSLSASVPPQATAGPSYPRPMTPPVSIPGQPNAAGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRRDLVKDDIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQLPSVDISVAVATDKGLITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKANLENPMRLG
Protein: Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 13 (AthCYSTM13) (Cysteine-rich and transmembrane domain-containing protein WIH1) (Protein WINDHOSE 1) (Q9FJW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the promotion of megasporogenesis, or promotion of germ cell formation from somatic precursor cells. Acts redundantly with WIH2. Functions in a genetic pathway downstream of SPL/NZZ and WUS and together with TRN2 in promoting megasporogenesis. Involved in resistance to abiotic stress.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29272523}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cysteine-rich and transmembrane domain-containing protein WIH2
- Protein SPOROCYTELESS
- Pollen Ole e 1 allergen and extensin family protein
- Tetraspanin-16
- Protein TORNADO 2
- Protein WUSCHEL
- Transmembrane protein
- Protein DYAD
- Pumilio homolog 12
- Protein TORNADO 1
Sequence:
MYHQEQHPVGAPPPQGYPPKDGYPPAGYPPAGYPPPGYAQGYPAQGYPPPQYSQAPQQKQNAGMLEGCLAALCCCCLLDACF
Protein: dATP triphosphohydrolase (dATPase) (A0A2L0V156)
Organism: Salmonella phage PMBT28
Function: Catalyzes the hydrolysis of dATP, dADP and dAMP into dA. This step is essential for Z-genome synthesis (containing aminoadenine instead of adenine). Specifically removes dATP and its precursor dADP from the nucleotide pool of the host, preventing the incorporation of A into the phage genome and favoring the integration of the Z-base into the viral genome.
Interaction partners:
Sequence:
MMTMTPRDLMRAQYVTRWQIVPTTRSQSVAQHSWAVAMLAMNLWCRRTGGQPGEAATDVELGKIAVMALWHDAPEVFTGDINTPTKIFLNASNALDELENTAGDGYLESMDGGPIRTCVKIADFLEAMYWLMEHGDGHYANNQLHGLNERFHQYLNEHAPLWRDSAVALWKELSDVNAETTTFQRVNYLKANDA
Protein: Transcription factor tau 60 kDa subunit (TFIIIC 60 kDa subunit) (Transcription factor C subunit 8) (Q12308)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Plays a role in TFIIB assembly through its interaction with SPT15/TBP. Essential for cell viability.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcription factor tau 91 kDa subunit
- Transcription factor tau 138 kDa subunit
- Transcription factor tau 95 kDa subunit
- Transcription factor tau 131 kDa subunit
- Transcription factor IIIB 70 kDa subunit
- Transcription factor TFIIIB component B''
- Transcription factor tau 55 kDa subunit
- TATA-box-binding protein
- DNA-directed RNA polymerase III subunit RPC1
Sequence:
MKLLKDLLVDRKEFEDWKNNLTWARDGTLYLTTFPDISIGQPKYAKDINCNSKNLFHVKEFPLEFENKLDFELAQQNGLLNSQPVCYPRVCKPSPIDDWMAVLSNNGNVSVFKDNKMLTNLDSKGNLSSRTYHCFEWNPIESSIVVGNEDGELQFFSIRKNSENTPEFYFESSIRLSDAGSKDWVTHIVWYEDVLVAALSNNSVFSMTVSASSHQPVSRMIQNASRRKITDLKIVDYKVVLTCPGYVHKIDLKNYSISSLKTGSLENFHIIPLNHEKESTILLMSNKTSYKVLLEDELHVTADNIIAPYLEKKFKKWSTIWNEFNNYETTLVIHGISLSPDGYSIAIVYDMERVAFKYKIASEQSFNIMFAPLYHTWTISERAVGLAWYQTYQIYNQSLPKLPENFSMNKKLLNGNYPISLDFQSYLNALMKSEEMRIIMFLNMTIDKPSILSFLEALYEYAINKKSELTNSFDLACVLSIAAILKREAPIYNGTLLMKNSFLEETFNLESFTADPETVTSTTNNTWKRCGVTLLPILTTHVKICPVSKQRVIDIKRDDLNDYGWFTRGLLERFNEISVYCGTTLEVM
Protein: Ribonuclease (EC 3.1.-.-) (P84784)
Organism: Thelephora ganbajun (Ganba fungus)
Function: Has ribonuclease activity towards yeast tRNA and polyuracil, and decreasing ribonuclease activity towards polyadenine, polycytosine and polyguanine respectively. Lacks antifungal activity against M.arachidicola and P.piricola. Inhibits HIV-1 reverse transcriptase.
Interaction partners:
Sequence:
DADIAVWAPPVNAQN
Protein: LD29081p (X11L, isoform A) (Q9VX41)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSNSCSDSSNESMVNPPHIQMNFGQQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNSPDLNGELSYVPLQGLSPSGGGVQGSGSYGSNAGRDSGSYYYQRPQLHQIRLGRSPGSQFETRDVLPQGLASPGSPTDVGKADGQCLRDGEIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLPIAEYEGSPRRFGSQPNTNTITMGGPRKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSPQEYPATPMEQAYIGQRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI
Protein: Ammonium transporter Rh type A (Erythrocyte membrane glycoprotein Rh50) (Rhesus blood group family type A glycoprotein) (Rh family type A glycoprotein) (Rh type A glycoprotein) (CD antigen CD241) (Q9QUT0)
Organism: Mus musculus (Mouse)
Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q02094}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02094}. Note=Localization at the plasma membrane is regulated by ANK1. {ECO:0000250|UniProtKB:Q02094}.
Interaction partners:
- Protein 4.2
- Band 3 anion transport protein
- Blood group Rh
- Ankyrin-1
- Glycophorin-A
- Spectrin alpha chain, erythrocytic 1
- Kell blood group glycoprotein homolog
- Erythroid membrane-associated protein
- Aquaporin-1
- Ankyrin-2
Sequence:
MRFKFPLMAISLEVAMIVLFGLFVEYETPQNASQKNASHQNASQQGNTSSSAKKDQFFQLYPLFQDVHVMIFVGFGFLMTFLKKYGFSGVGFNLFLAALGLQWGTIMQGLLHSHGKEFHFGIYNMINADFSTATVLISFGAVLGKTSPIQMLIMTILEIAVFAGNEYLVTELFEASDTGASMTIHAFGAYFGLAVAGVLYRPGLRCEHPNDESVYHSDLFAMIGTLFLWIFWPSFNSAIADPGDHQYRAIVNTYMSLAACVITAYALSSLVERRGRLDMVHIQNATLAGGVAVGTCADMEIPLYAAMTIGSIAGIISVLGYKFFSPLLANKLMIHDTCGVHNLHGLPGVFGGLASIVAISWGMSTASMAMQAAALGSSIGSAIVGGLLTGLILKLPIWNQPPDEYCYDDSVSWKVPKFRELDNRFFQHANHNHVEHEV
Protein: Hyccin (Down-regulated by CTNNB1 protein A) (Q6P9N1)
Organism: Mus musculus (Mouse)
Function: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYI3}. Cell membrane {ECO:0000250|UniProtKB:Q9BYI3}. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex. {ECO:0000250|UniProtKB:Q9BYI3}.
Interaction partners:
- Tetratricopeptide repeat protein 7B
- Tetratricopeptide repeat protein 7A
- Phosphatidylinositol 4-kinase alpha
- Protein EFR3 homolog A
- Protein EFR3 homolog B
Sequence:
MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVTSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELMWCYLAVSASRDVHSSGCIEALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYRGVSSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTELTGQEELMDITEVDEGFYSRAASSTSQSGLSNSSHNCSNKTSVGKNQRRSGGSKAGAKERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSQGLAKTAATVFSKSFEQVSGAPVPRSPSPAIGCVAGADANRFSACSLQEEKLIYVSERTELAVKCQAGQQGPPSISVTLSAE
Protein: SNW domain-containing protein 1 (Q6DRP3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367140}.
Interaction partners:
- Crooked neck-like protein 1
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor RBM22
- Protein BUD31 homolog
- Cell division cycle 5-like protein
- Cell division cycle 40 homolog
- Pre-mRNA-processing factor 19
- Pre-mRNA-processing factor 8.
- Pleiotropic regulator 1.
- Protein CWC15 homolog
Sequence:
MSLTSFLPAPTQLSQDQLEAEERSQAYRSQSTALVSTRRDPPPYGFRKSWVPRALEDFGDGGAFPEIHVAQYPLEMGRKKRTSNALAVQVDAEGKIKYDAIARQGQSKDKVIFSKYTDMLPKEVLNQDDPELQKPDEEAVRELTEKTRLALEKQVSQKIAAAMPVRAADKQAPAQYIRYTPSQQGLAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVEKKMAQKEKEKKEEKLRELAKMARDRRAGIKPHGDKGGEDSEVRERDEIRHDRRKDRQHDRNISRAAPDKRSKLQRDQDRDISELIALGQPNPRTSSEAQYDQRLFNQSKGMDSGFAGGEDEMYNVYDQPFRGGRDMAQNIYRPSKNVDKDMYGDDLDTLMQNNRFVPDRDFSGADHGPRRDGPVQFEEDPFGLDKFLEEAKQHGGSKRASTSGRSKDYDHEKKRRKE
Protein: SD07605p (Q960C8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTILQDNDPKLMNKRKLLGLEANSPNLSAVLLEAKKDADQMEQSLQQLQLKRQKAQLRFEILFENYCGLVHFEALEILSKESRLKLDTLLDAVSGNARAELQETINEVKELIELEDLDVESEGDYEAEELSERLAATIKDAELGIQFDDIANHWTQSLSWLTSEEATAADLEQAYAKSIHALSEACALEMCKLHKIAELLLVKPHHSTANEVDGVVNLCQQFNGHLQGLSHRFAAVLSGKSETEESKGRVSTFFSEMLSAVQFIEKAYKLFTPILQMGAV
Protein: Anion transporter SULP-8a (Anion transporter SULP-8b) (STAS domain-containing protein) (G5EFB2)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- thiosulfate sulfurtransferase
Sequence:
MKEVYQPCTTTDQDIVEKKECSPFRKKLQKYIPILEWLPNYQWKDHFHGDVIAGLTVGIMHVPQGMAYASLAGVPPVYGMYSSFFASTIYMFFGTARHISIGVFAVASMMVGAARLRLAPDIPISNSSDINPSVYPLGEYVDPLVFTSALTLLVGVVQIIMGILRLGFLTTYLSDSLVSGFTTGAAVHVFTSQLNKVFGIKLPRHEGIGMIVRMYRDMIMSLGSVNFVALGISIFGILFLDLGRTYINPIVKKFSPIPPPLELILVIFGIVISMIFNLDAEYHVKTVYEIPRGFPLPSIPRLNFLPALLSDAIPIAVVCYMFVMSMGKLFAKKHKYKTDATQELYAIGIASALSSFFPVYPVGASLSRSSVCEMSGANTQLYTIFSSFLLLTVILLLGPFLEPLPMCILACIVIVSLKSLFMQVKELPRLYRISKYDFAIWLVACLSTIFTDVTTGLVISLAFSLYTLVLRQQWPSFSTVLHDETPRQNVPENVKIVKFAGSLHFANVTAFQDDMGEAIGKLPEEDPLIDERTIILDASSVAFIDIMGVDALRDVFKDALKLGVHVFYCGLPEDVLSVLSNDENFLSVVPPSTFFPSIDSCLISFVHQQSV
Protein: Cathelicidin-derived antimicrobial peptide 2b (A0A0F6QFC0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKALVRSLLLLAVANLLVRGQTQTETRYEDIITAASNQLLPVEEQAFHPLLNQLEVETLNTEDVDQSEVSVRLSFPLQETLCSKAQGQRGQPCPLKKNGKRMMCSMEVRHPILEIGNTLNTDRSDISCEYMEAEVQKIRTRRGKDSGGPKMGRKYSKGGWRGRPGSGSRPGFGSSIAGASGVNHVGTLTA
Protein: Omp-1X (Q2GIQ1)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MKKKICVFALPTVMFMLPSLSFASPKPVDFSRQAGIEGFFSSIQYKYAVPYFGAFSLVHGGNPLDVFSAKDAESSSGIATLLQSVASTSTSDAENFQGKYNPSYLHSKQALSASAGYSTGYVRVEVEGMHQKFLVDPKRYKERDKAKAYRFAASASSGGTGQPTATHPNEKYYISLENRDLIITSLVANLCYDMIPEESRLSPNICVGAGIGYVKAFGVLEQRWAYQAKVGVQYFLSRKASVFLSAYVDKVNGEKFKNVRVKHNIGTRSSSSGGTSQSISTDSILYPDAHLSLLYYGLECGVRLTL
Protein: Probable phosphatase PSR2 (EC 3.1.3.-) (Plasma membrane sodium response protein 2) (Q07949)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable phosphatase. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR1. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
Subcellular location: Cell membrane {ECO:0000250}.
Interaction partners:
- Growth regulation protein
- Phosphatase PSR1
- Transcription initiation factor IIF subunit alpha
Sequence:
MGFIANILCCSSDTSKTHRQRQPPETNHNRNRNRKHSSNKAQTQGRKQKATPNGDKMQYSTPEILLSSSDSGSNAGSKTMQENGNSGNGKLAPLSRDHSNNSYDEEKEYEDYNEGDVEMTEVNNAGEEEEEDDEAKEKQDHVVHEYNVDADRNSSINDEAPPQQGLYQVGQEDMNPQYVASSPDNDLNLIPTTEEDFSDLTHLQPDQYHAPGYDTLLPPKLQEFQQKKCLILDLDETLVHSSFKYMHSADFVLPVEIDDQVHNVYVIKRPGVDEFLNRVSQLYEVVVFTASVSRYANPLLDTLDPNGTIHHRLFREACYNYEGNYIKNLSQIGRPLSETIILDNSPASYIFHPQHAVPISSWFSDTHDNELLDIIPLLEDLSSGNVLDVGSVLDVTI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F7F4E2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKSHQSHGSTSSKAHDSASCSQSQGGFSQSQGTPSQLHDLSQYQGASSSSTSTVPSSSQSSHSSSGTLSSLETVSTQELCSIPEDQEPEEPGPTPWARLWALQDGFSNLDCVNDNYWFGRDKSCEYCFDGPLLKRTDKYRTYSKKHFRIFREMGPKNCYIVYLEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMAFERKTCKKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDVEDYYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNLIPEVWTDVSEKGMDTKGLQASGLTDVWVSCWWERLLRLLVFSHLVILLLCTT
Protein: Small integral membrane protein 21 (Q3B7S5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDQYVSTAPPRFPIAQLGTFKQDSAGMGRIFKGNLLQKKALTTFENEHHIRFFTLLVLFHVMVLLRNHSRIQGVSEDWKRANSIFRNFLRLKSSRNTAEAE