wanglab/gogpt-training-data huggingface dataset:
Protein: [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) (O94851)
Organism: Homo sapiens (Human)
Function: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Subcellular location: Nucleus {ECO:0000269|PubMed:24440334}. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}.
Interaction partners:
- Enhancer of filamentation 1
- Ras-related protein Rab-8A
- Plexin-A4
Sequence:
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTSPKRPKSISEPQHSDAEGDAASPLPSEWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDTESDYGGSEGSHTEPCEEKPWRPGSPHLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSFQSPTPSKYQNWRREFWWSLTPVNKRTMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSVSGNAPDGSSPPQMTASEPLSQVSRGHPSPPTPNFRRRAVAQGAPREIPLYLPHHPKPEWAEYCLVSPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTGQELSPLAGEDREKGSTGARKEEEGGPVLVKEKLGLKKLVLTQEQKTMLLDWNDSIPESVHLKAGERISQKSAENGRGGRVLKPVRPLLLPRAAGEPLPTQRGAQEKMGTPAEQAQGERNVPPPKSPLRLIANAIRRSLEPLLSNSEGGKKAWAKQESKTLPAQACTRSFSLRKTNSNKDGDQHSPGRNQSSAFSPPDPALRTHSLPNRPSKVFPALRSPPCSKIEDVPTLLEKVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRKDIRDLFGSPKRKVLPEDSAQALEKLLQPFKSTSLRQAAPPPPPPPPPPPPPPTAGGADSKNFPLRAQVTEASSSASSTSSSSADEEFDPQLSLQLKEKKTLRRRKKLEKAMKQLVKQEELKRLYKAQAIQRQLEEVEERQRASEIQGVRLEKALRGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLREKMLKEESQKDEKDLNEEQEVFTELMQVIEQRDKLVDSLEEQRIREKAEDQHFESFVFSRGCQLSRT
Protein: Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (hGR3) (P49683)
Organism: Homo sapiens (Human)
Function: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prolactin-releasing peptide
- Pro-FMRFamide-related neuropeptide FF
- Glutamate receptor-interacting protein 2
- Pro-neuropeptide Y
- PRKCA-binding protein
Sequence:
MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
Protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (EC 3.6.4.13) (Helicase JA1) (P53131)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.
Subcellular location: Nucleus.
Interaction partners:
- Pre-mRNA-splicing factor SNU114
- Protein SQS1
- Probable ATP-dependent RNA helicase DHR2
- Protein PXR1
- Pre-mRNA-splicing factor BUD31
- Pre-mRNA-splicing factor SPP382
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-processing protein 45
- Ribosome biogenesis protein BMS1
- Something about silencing protein 10
Sequence:
MGSKRRFSSEHPDPVETSIPEQAAEIAEELSKQHPLPSEEPLVHHDAGEFKGLQRHHTSAEEAQKLEDGKINPFTGREFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAIRTVLQIHATEEAGDILLFLTGEDEIEDAVRKISLEGDQLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKKRADDAKNIFAHPDGDHITLLNVYHAFKSDEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYESPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTVLGHDAEWVIYNEFVLTSKNYIRTVTSVRPEWLIEIAPAYYDLSNFQKGDVKLSLERIKEKVDRLNELKQGKNKKKSKHSKK
Protein: Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) (Q5T5U3)
Organism: Homo sapiens (Human)
Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
Interaction partners:
- ADP-ribosylation factor 1
- Transforming protein RhoA
- Cell division control protein 42 homolog
- Prickle-like protein 1
- Catenin beta-1
Sequence:
MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEEVRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISSSRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGICERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQTTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLLNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEAETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRRRHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQINGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL
Protein: Beta-D-glucan exohydrolase-like protein (Glycosyl hydrolase family protein) (Putative beta-D-glucan exohydrolase) (Q8W112)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGTLSKVLCLMLLCCIVAAAEGTLKYKDPKQPLGARIRDLMNRMTLQEKIGQMVQIERSVATPEVMKKYFIGSVLSGGGSVPSEKATPETWVNMVNEIQKASLSTRLGIPMIYGIDAVHGHNNVYGATIFPHNVGLGVTRDPNLVKRIGAATALEVRATGIPYAFAPCIAVCRDPRWGRCYESYSEDYRIVQQMTEIIPGLQGDLPTKRKGVPFVGGKTKVAACAKHFVGDGGTVRGIDENNTVIDSKGLFGIHMPGYYNAVNKGVATIMVSYSAWNGLRMHANKELVTGFLKNKLKFRGFVISDWQGIDRITTPPHLNYSYSVYAGISAGIDMIMVPYNYTEFIDEISSQIQKKLIPISRIDDALKRILRVKFTMGLFEEPLADLSFANQLGSKEHRELAREAVRKSLVLLKNGKTGAKPLLPLPKKSGKILVAGAHADNLGYQCGGWTITWQGLNGNDHTVGTTILAAVKNTVAPTTQVVYSQNPDANFVKSGKFDYAIVVVGEPPYAEMFGDTTNLTISDPGPSIIGNVCGSVKCVVVVVSGRPVVIQPYVSTIDALVAAWLPGTEGQGVADALFGDYGFTGKLARTWFKSVKQLPMNVGDRHYDPLYPFGFGLTTKPYKM
Protein: Keratin 13 (A1A4E9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAVDDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP
Protein: Replication-associated recombination protein A (P0AAZ4)
Organism: Escherichia coli (strain K12)
Function: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.
Interaction partners:
- ATP-dependent DNA helicase RecQ
- Outer-membrane lipoprotein carrier protein
- O-acetyl-ADP-ribose deacetylase
- DNA translocase FtsK
- Small ribosomal subunit protein uS4
- L-arabinose transport system permease protein AraH
- Leucine-responsive regulatory protein
- Multiple antibiotic resistance protein MarA
- DNA polymerase III subunit tau
- Replication restart protein DnaT
Sequence:
MSNLSLDFSDNTFQPLAARMRPENLAQYIGQQHLLAAGKPLPRAIEAGHLHSMILWGPPGTGKTTLAEVIARYANADVERISAVTSGVKEIREAIERARQNRNAGRRTILFVDEVHRFNKSQQDAFLPHIEDGTITFIGATTENPSFELNSALLSRARVYLLKSLSTEDIEQVLTQAMEDKTRGYGGQDIVLPDETRRAIAELVNGDARRALNTLEMMADMAEVDDSGKRVLKPELLTEIAGERSARFDNKGDRFYDLISALHKSVRGSAPDAALYWYARIITAGGDPLYVARRCLAIASEDVGNADPRAMQVAIAAWDCFTRVGPAEGERAIAQAIVYLACAPKSNAVYTAFKAALADARERPDYDVPVHLRNAPTKLMKEMGYGQEYRYAHDEANAYAAGEVYFPPEIAQTRYYFPTNRGLEGKIGEKLAWLAEQDQNSPIKRYR
Protein: Receptor-associated protein of the synapse (A0A8I6AIQ1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNDYGKGWSLKYRAMSQYHMAVAYRLLGHLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLELSQLKLHCLSEGICRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV
Protein: IAA-amino acid hydrolase ILR1-like 2 (EC 3.5.1.-) (P54970)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA), including IAA-Ala, IAA-Leu, IAA-Met, IAA-Phe, IAA-Ser, IAA-Thr, IAA-Tyr and IAA-Val. Is the most efficient enzyme of the ILL family for IAA-Ala. Not important for IAA-Leu hydrolysis in roots. May act with ILR1 to provide free IAA to germinating seedlings.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Protein LONG AFTER FAR-RED 3
- UDP-glycosyltransferase 84B1
Sequence:
MALNKLLSLTFQLLLFLLSVSSESPWIAEDTSQIQTKLLEFAKSPEVFDWMVKIRRKIHENPELGYEELETSKLIRSELELIGIKYRYPVAITGVIGYIGTGEPPFVALRADMDALPIQEGVEWEHKSKIAGKMHACGHDGHVTMLLGAAKILHEHRHHLQGTVVLIFQPAEEGLSGAKKMREEGALKNVEAIFGIHLSARIPFGKAASRAGSFLAGAGVFEAVITGKGGHAAIPQHTIDPVVAASSIVLSLQQLVSRETDPLDSKVVTVSKVNGGNAFNVIPDSITIGGTLRAFTGFTQLQQRVKEVITKQAAVHRCNASVNLTPNGREPMPPTVNNKDLYKQFKKVVRDLLGQEAFVEAAPVMGSEDFSYFAETIPGHFSLLGMQDETNGYASSHSPLYRINEDVLPYGAAIHASMAVQYLKEKASKGSVSGFHEEL
Protein: Cytochrome P450 monooxygenase AN1598 (EC 1.-.-.-) (Pimaradiene biosynthesis cluster protein AN1598) (C8VN91)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD). Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors. The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is needed in the formation of GGPP, the precursor for diterpenes. Lastly, the pimaradiene synthase pbcA performs the 2 cyclization steps that convert GGPP to ent-pimara-8(14),15-diene. The putative roles of the remaining cluster enzymes in ent-pimara-8(14),15-diene biosynthesis is unclear (Probable). The cytochrome P450 monooxygenase AN1598, the glutathione S-transferase AN1595, the oxidoreductases AN1596 and AN1597 probably function as decorative enzymes (Probable). It is possible that in biological conditions the compound is oxidized to ent-pimara-8(14),15-dien-19-oic acid, which is a bioactive diterpene compound predominant in many plant extracts (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDNYTWHSGTLIPSDSPSSIDRSQLYLEILGVLSVVYLLQTLVAYSKSFKAPFVGFRFWYEPKWLVGLRFSQGALAQVNEGYAKYKNAMFKVARNDSDILVIPNKYVEELRSLPDEKISAIRAHIKNLLGKYSTTLILLESDLHTRMLQTKLTPNLGSFIEVIESELLFAMDQEIPANLDDWQSVNVFHIVLRIVARISARVFLGVPACRNEEWLQTSIHYTENVFATVMLLRRFPKWMHPIVGHLLPSYWAIHRNLRTAKRIISPMVRQRRAEEAKRNPDYVKPNDLLQWMMDGANENDGQPDKLAHRQLLLSLASIHTTTMAAAHCFYDLCQHPEYFEPLREEINDVIAQDGGWKKTTLNKMRKLDSFLKESQRINPPSLLAFNRIVSEDLTLSDGTLLPKGTHFSMPSAAILQDNGVEPGADQFDGFRYYKKRLNPEEANKHQFAMTDNNNLHFGHGKYSCPGRFFASNEIKIIMAHLLTDYEFKYPRGATRPRNLTADENLYPDPSARLLMRRRVVAPPQASITPQLVSA
Protein: Peroxisome assembly protein 22 (Peroxin-22) (P39718)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in peroxisome biogenesis.
Subcellular location: Peroxisome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2-21 kDa
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX15
- Peroxisomal ATPase PEX1
- Peroxisomal targeting signal receptor
- Proteasome subunit beta type-6
- Peroxisome biogenesis factor 10
- Peroxisome assembly protein 12
- Peroxisomal biogenesis factor 8
- Peroxisomal membrane protein import receptor PEX19
Sequence:
MPPPSRSRINKTRTLGIVGTAIAVLVTSYYIYQKVTSAKEDNGARPPEGDSVKENKKARKSKCIIMSKSIQGLPIKWEEYAADEVVLLVPTSHTDGSMKQAIGDAFRKTKNEHKIIYCDSMDGLWSCVRRLGKFQCILNSRDFTSSGGSDAAVVPEDIGRFVKFVVDSDVEDVLIDTLCN
Protein: Cyclin-A2 (Cyclin-A) (Cyclin A) (P20248)
Organism: Homo sapiens (Human)
Function: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Cytoplasm {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}.
Interaction partners:
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 2
- S-phase kinase-associated protein 2
- Transcription factor E2F1
- Cyclin-dependent kinase inhibitor 1B
- Cell division cycle protein 20 homolog
- Anaphase-promoting complex subunit 4
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 6
Sequence:
MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
Protein: Polybromo 1 (E7EVG2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKRAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPG
Protein: Vig2, isoform B (Q9VBX3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL3
- 40S ribosomal protein S15
- Large ribosomal subunit protein eL31
- FI01658p
Sequence:
MQLAEKHIVALMFPAIDVSTFTFVSGVKFYIMDNSGNNRYELLFMDDDDSSGLAQPQIAAVVAAPKKPEPAKAPKAPKSKSEKENKPVVAARKANAPVAKNASPVKGGKGPAGGDVGRPKNPTANGANNQGRFNNNQRYGNKESNGEFGNELPQRQFNNRDNRGPPRVRTGEKFGKREFDRQSGSDRTGVKSIDKREGGGAHNWGSPKQDIEDLKTTGETSPQAEKEDSANEQSADPAVAAEEDESKQMTLDEWKALRDQRAKPNYNLRKAGEGAADNAEWKKMIVLSKKKESNSEDELEYDPSLYPQRVGRLQRIVDIQFNFNDGRKVGFRKGPRPGAGPREGGFRNDGPRGEGGYRNDGPRGEGGYRNDGPRGEGPRNEGPRGEGYRNDGPRGEGFRGPRFNNGPSNGYENRQDNNRFGEKRRSAQKPLKVDDEAQFPTLC
Protein: SAFB protein (A5PJP2)
Organism: Bos taurus (Bovine)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Apoptotic chromatin condensation inducer 1.
- RNA binding motif protein X-linked
- RNA-binding motif protein, X chromosome
- Scaffold attachment factor B2
- SFRS4 protein
Sequence:
MAESLSGLGDSGAAGAAALSSASSETGTRRLTDLRVIDLRAELKKRNLDSSGNKSALMERLRKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDMMDISVLDEAEIDNGSVADCVEDDDAENLQESLSDSRELVEGEMKELPEQLQEHAVEDKESINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPIGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSVEDDSDTKKLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPAGKKSSERREGEGKKEKSSNTDRSANLKREEKADRKDDAKKGEDGSGEKSEDQDDQKPGSSERSRATKSGSRGTERTVVMDKSKGVPVISVKTLGSKERVSKSQDRKSASREKRSVVSFDEVKESRKSRDSESRRLREHSEREQSMQAELERQERKKLLIARERLAFHRHRLERERMERERLERERRRVEHERRREQERIHHEREELRRQQELRYEQERRPAVRRPYDYGRRDDVYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSIMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRGRREWGDHGRRIEEDRAWQGAADGGLMDRDHRRWQGGERSMSGHMMNRGGMSGRGSFAPGGASRGHVIPRGGFGSRPTDAHFTRRY
Protein: Protein transport protein SEC23 (F4JUM1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}.
Interaction partners:
- Protein transport protein SEC24 C
- Protein transport protein SEC24 A
- Protein transport protein SEC24 B
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC13 homolog A
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC23 D
- small monomeric GTPase
- Small COPII coat GTPase SAR1B
Sequence:
MAEMADKAKVEEMDWEGIDGVRMTWNLWPRTKVEASKCVIPLAASISPIRRHPLILDLPYAPLDCKTCKALLNAFARVDFAAMNWVCPFCYHRNHFPSHYHSISEINLPGELYPQYTTVEYTLPPDPSRVPPPPVFVFVLDTCMIEEELGYAKSALKQAIGLLPENALVGFVSFGTQAHVHELGFSEMSKVFVFKGNKEVTKDQILDQLGLGSSSRRAPTSGFSKGAQNGFQSSGVDRFLLPASECEYTLDLLLDELQSDQWPVQPGHRPQRCTGVALSVAAGLLGACLPGTGARIVALVGGPCTEGPGTIISKDLSDPVRSHKDLDKDAAPYYKKAVKFYDSIAKQLVAQGHVLDLFASALDQVGVAEMKVAVESTGGLVVLSESFGHSVFKDSFKRMFEDGEHSLGLCFNGTLEINCSKDIKIQGVIGPCSSLEKKGPNVADTVIGEGNTSAWKLCGLDKSTCLTVFFDLSSTGSTAPGALNQQLYLQFITRYQNSEGKSLARVTTLTRQWVDTAVSTEVNLVQGFDQETAAVVMARLTSLKMETEEGFDATRWLDRTLIRLCSKFGEYRKDDPTSFTLKPYLTLFPQFMFNLRRSQFVQVFNNSPDETAYFRMLLNRENISNAIVMIQPSLTSYSFNSGPQAALLDVASIAADKILLLDAYFSVVVFHGMTISQWRNMGYHHQPEHEAFAQLLQAPQEDSQMLVRERFPVPRLVVCDQHGSQARFLLAKLNPSATYNNANEMSAGSDIIFTDDVSLQVFIEHLQKLAVQS
Protein: Protein KRE1 (G8BEK5)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
Sequence:
MQLLHTLLSLFSFVLMTHGLANQGAGGGAGGDAKTSSNTIVWVTTTIDGKLTTASTTFSQTFMSTYTEANSNDVESGTVGMGSLSGSVGNVKSYDKTTISNAAPDGAAYMPYNVYAGFVGGVAVLLGLF
Protein: Eye transformer, isoform C (M9NE35)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Tyrosine-protein kinase hopscotch
- Cytokine receptor
Sequence:
MGWRTRISRLLSLTLLATLMARALAENALHMPQANCEMQSLGGPSWRSGTIGKVSCKCDGGEGRKMSVRRQGTIESTDSYNGTVVHVDANPANEWERRYECLLDGVIQSHVCVRVYALLNLKDFVCRDVVYYLRCTFSRMENGNFENKTHYQLAMGRAKPIDCRKSEDERSRGKVECSVPIDPNSRAPEWRDFRLIMSDDLGNQSKVLRLTQAEMEVLEWPRGKHNMIQTPNQTCLEWNGPFIYPNRTFELNVQFRHSKLPNLSRNLTVSQMRAVSVFDQVCFGNPPEGNQLFYVSLSRRLHGSPWSERYPEFELTTNASLPARPPRFLANGFSHDRAKRELKVYWLPLDELEFNGAEQTYVASTRYGTKVATTQGSMLAIFTDWDDTQPATVSVWSSNVVGRSLESSQLEVPRLSDIRDRRIYLESYNKTSSRLSWQGPEELGNFTGYIVYWCKLSSKVHDACDDSSSIETTYARETAYNFSGIQGVIRMAVAANYSDGLTTGMRWWSGDSEVPEKPKILRYVEGTIALLVLGSLVLAIQKLRQMADIRVELPVMSEEPTANPLGDVRLFYPANVPPEKFYGTVRKTVTFAEEEPTRWPEIELQEVPRPQPVPQADAYVTNQYVSMSAIGAPCGDGYIKPPPVR