wanglab/gogpt-training-data huggingface dataset:
Protein: Probable S-(hydroxymethyl)glutathione dehydrogenase 1 (EC 1.1.1.284) (Alcohol dehydrogenase 1) (EC 1.1.1.1) (Glutathione-dependent formaldehyde dehydrogenase 1) (FALDH 1) (FDH 1) (FLD 1) (GSH-FDH 1) (EC 1.1.1.-) (P78870)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Alcohol dehydrogenase 4
- Alcohol dehydrogenase
- Putative aldehyde dehydrogenase-like protein C922.07c
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Probable pyruvate decarboxylase Pdc101
- Putative pyruvate decarboxylase C3G9.11c
- Putative pyruvate decarboxylase C13A11.06
- Probable pyruvate decarboxylase C186.09
- Uncharacterized oxidoreductase C26F1.07
- Putative S-
Sequence:
MSFEGKTITCKAAVAWGAKEPLSIEDIQVAPPKAHEVRVKVDWSAVCHTDAYTLSGVDPEGAFPIVLGHEGAGIVESIGEGVINVRPGDHVILLYTPECKECKFCRSGKTNLCSKIRETQGRGLMPDGTSRFSCRDKTLLHYMGCSSFSQYTVVADISLVAISHSAPLRSICLLGCGVTTGFGAVTHSAKVESGSTVAVVGCGCVGLAAMQGAVAAGASRIIAIDINADKEVYAKKFGATDFIDSSKVKDLVQYVIDVTDGGVDYAFDCTGNVTVMQQELQFCHKGWGKLCVIGVAAAGKTLDFRPFLVVTGRQVLGSAFGGVKGRSELPNFVDEYMQGHFKVDEYITNEEPLKNINKAFDHMHEGKCIRCVVDMNKP
Protein: Retinoic acid receptor RXR-beta-B (Nuclear receptor subfamily 2 group B member 2-B) (Retinoic acid receptor RXR-delta) (Retinoid X receptor beta-B) (Retinoid X receptor delta) (Q90417)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Nuclear receptor subfamily 1, group H, member 3
- NACHT, LRR and PYD domains-containing protein 3 isoform X1
Sequence:
MNSLPPSTSAVSSPVSSVDSPLSAVSSSIGSPGVPGTPSIGYGPISNSQINSSMSVSRLHAVSSSDDVKPPFGLKSVSGSGPMLSQKRMCAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLSYTCRDNKECLVDKRQRNRCQYCRYQKCLAMGMKREAVQEERQKNKERDGDYECSSSANEEMPVEKILEAETAVEHRTDLHSDATGSPNDPVTNICQAADKQLFTLVEWAKRVPHFSDVPLDDQVILLRAGWNELLIAAFSHRSISVKDEILLATGLHVPKESTHNLGVEAFFDRESSHSAEVGALFDRVLTELVCKMRDMQMDKTELGCLRAIVLFNPDAKGLTSSSEVELLREKVYASLESYCKQKYPDQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGNTPIDTFLMEMLESPH
Protein: Solute carrier family 22 member 7 (Organic anion transporter 2) (mOAT2) (Q91WU2)
Organism: Mus musculus (Mouse)
Function: Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha-ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9Y694}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y694}. Apical cell membrane {ECO:0000269|PubMed:16256982}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9Y694}; Multi-pass membrane protein {ECO:0000305}. Note=Apical side of the renal tubule. {ECO:0000269|PubMed:16256982}.
Interaction partners:
- Organic anion transporter 3
- Solute carrier organic anion transporter family member 1A1
- Solute carrier organic anion transporter family member 2B1
- ATP-binding cassette sub-family C member 4
- Solute carrier family 2, facilitated glucose transporter member 9
- Solute carrier organic anion transporter family member 1B2
- Solute carrier organic anion transporter family member 1A4
- Hepatic sodium/bile acid cotransporter
- ATP-binding cassette sub-family C member 2
- Solute carrier organic anion transporter family member 4C1
Sequence:
MGFEELLHKVGGFGPFQLRNLVLLALPRFLLPMHFLLPIFMAAVPAHHCALPDAPANLSHQDLWLKTHLPRETDGSFSSCLRFAYPQALPNVTLGTEVYNSGEPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCEQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVSTLALGLMSAASVNYIMFVTTRMLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTTFWTGGVLLLTLVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISEDSLSQEALNKVITMERVSQRPSYLDLFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGLTVYQTQLLFGAVEVPSKITVFFLVRLVGRRLTEAGMLLATALTFGISLLVSSDTKSWITALVVIGKAFSEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKLAYGGISFLAACTVLLLPETKKAQLPETIQDVERKGRKIDRSGTELA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (E7ETY4)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Protein: AGAMOUS-like 94 (MADS-box protein) (Q766C0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRVKLKIKKLQNMNGRQCTYTKRRHGIMKKAKELSILCDIDVVLLMFSPMGKASICIGKHSIGEVIAKFAQLSPQERAKRKLENLEALRKTFMKANHDIDISKFLDRISTPTVEVLSEKIRFLQTQLSDIHTRLSYWTDVDNIDSVDVLQQLEHSLRQSLAQIYGRKASMPQRQQQQLMSSQCKNQLQTEIDIDFGMEMEQQLENFSWVRTDENMNVPIEEEDPNLQLHHMYKDITCSASSALGNYSGLFSKSSDILQKLETGSIPGTSADPNQQFSNLSFLNDQKLKQLAEWNLLGSPADYYVSQILEASYKPQIGGKNNGASSETLPYVAVFDDPLYFWPN
Protein: Protein NARROW LEAF 1 (Protein GREEN FOR PHOTOSYNTHESIS) (Protein QUANTITATIVE TRAIT LOCUS FOR FLAG LEAF WIDTH 4) (qFLW4) (Protein SPIKELET NUMBER) (B4XT64)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the regulation of lateral leaf growth. May be involved in the regulation of basipetal polar auxin transport (PAT) and vascular patterning in leaves. Controls photosynthesis rate by regulating carboxylation efficiency and consequently photosynthesis rate. Controls panicle and spikelet numbers, and grain yield.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:18562767}. Cytoplasm {ECO:0000269|PubMed:18562767}. Note=Expressed in discrete structures which appeared similar to nuclear protein bodies. {ECO:0000269|PubMed:18562767}.
Interaction partners:
- Aminomethyltransferase
- FAD-dependent oxidoreductase domain-containing protein 1
- Os06g0611900 protein
- glycine dehydrogenase
- Lipoate-protein ligase A
- Putative bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- thymidylate synthase
- Proline dehydrogenase
- Serine hydroxymethyltransferase
Sequence:
MKPSDDKAQLSGLAQSEESSLDVDHQSFPCSPSIQPVASGCTHTENSAAYFLWPTSNLQHCAAEGRANYFGNLQKGLLPRHPGRLPKGQQANSLLDLMTIRAFHSKILRRFSLGTAVGFRIRKGDLTDIPAILVFVARKVHKKWLNPAQCLPAILEGPGGVWCDVDVVEFSYYGAPAQTPKEQMFSELVDKLCGSDECIGSGSQVASHETFGTLGAIVKRRTGNKQVGFLTNHHVAVDLDYPNQKMFHPLPPNLGPGVYLGAVERATSFITDDVWYGIYAGTNPETFVRADGAFIPFADDFDISTVTTVVRGVGDIGDVKVIDLQCPLNSLIGRQVCKVGRSSGHTTGTVMAYALEYNDEKGICFFTDILVVGENRQTFDLEGDSGSLIILTSQDGEKPRPIGIIWGGTANRGRLKLTSDHGPENWTSGVDLGRLLDRLELDIIITNESLQDAVQQQRFALVAAVTSAVGESSGVPVAIPEEKIEEIFEPLGIQIQQLPRHDVAASGTEGEEASNTVVNVEEHQFISNFVGMSPVRDDQDAPRSITNLNNPSEEELAMSLHLGDREPKRLRSDSGSSLDLEK
Protein: Retinoblastoma-associated protein (p110-RB1) (pRb) (Rb) (pp105) (P13405)
Organism: Mus musculus (Mouse)
Function: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:36689330, ECO:0000269|PubMed:8336704}. Cytoplasm {ECO:0000269|PubMed:36689330}. Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization (By similarity). Localizes to the cytoplasm when hyperphosphorylated (PubMed:36689330). {ECO:0000250|UniProtKB:P06400, ECO:0000269|PubMed:36689330}.
Interaction partners:
- Cyclin-dependent kinase 4
- Transcription factor E2F1
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Cyclin-dependent kinase 2
- Histone deacetylase 1
- Transcription factor E2F2
- E3 ubiquitin-protein ligase Mdm2
- G1/S-specific cyclin-D1
- Transcription factor E2F3
- Transcription factor E2F4
Sequence:
MPPKAPRRAAAAEPPPPPPPPPREDDPAQDSGPEELPLARLEFEEIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSALSTEINSMLVLKISWITFLLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFINSLGIVSSNGLPEVESLSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEANVVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDNLEPACPLSLPLQGNHTAADMYLSPLRSPKKRTSTTRVNSAANTETQAASAFHTQKPLKSTSLALFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHLPAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK
Protein: Tyrosine kinase (Q24315)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
CVYVCVGLSKTNNRKPDRKSAEKTISQSSTARAATIILVLLFIFFSRYLVYASVTMSLMKIHRGNESFCSCWLLLLLLVALLLAEAIVAAAAATLSETQTNATNGAIREPPVQLQLQQQQLQLQLQLNATAADGESRNSAEIFSPGDVDVVGDKPTTYRPSGANRPSIAPLNSAQDRERKLMNVLAARRTALHRGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASSKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFQDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWADDDSAASDYMDVSGFSEDLEHGVVYFNHRISEFECEI
Protein: RNA polymerase II, I and III subunit E (A0A087WWX0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Protein: Nitroreductase domain-containing protein (P95233)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Molybdopterin synthase catalytic subunit 1
- Possible molybdopterin biosynthesis protein MoeW
- Probable membrane protein
- Uncharacterized protein Rv2209
- PE-PGRS family protein PE_PGRS43
- PPE family protein PPE8
- PPE family protein PPE55
- PE-PGRS family protein PE_PGRS28
- PPE family protein PPE56
- Isoniazid-induced protein IniB
Sequence:
MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRRVRLWGDQTWRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVAEIDVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA
Protein: Proteinase 3 (U3KPS2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
Protein: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Component of peroxynitrite reductase/peroxidase complex) (Component of PNR/P) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex component E2) (PDH component E2) (P9WIS7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Interaction partners:
- Dihydrolipoyl dehydrogenase
- Pyruvate dehydrogenase E1 component
- Multifunctional 2-oxoglutarate metabolism enzyme
- 3-methyl-2-oxobutanoate dehydrogenase subunit beta
- Succinate--CoA ligase subunit beta
- 3-methyl-2-oxobutanoate dehydrogenase subunit alpha
- Probable dehydrogenase
- Succinate--CoA ligase subunit alpha
- NAD
- Lipoyl synthase
Sequence:
MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL
Protein: Kinesin-like protein KIF18B (Q86Y91)
Organism: Homo sapiens (Human)
Function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase.
Interaction partners:
- Kinesin-like protein KIF2C
- Tastin
- Chromosome-associated kinesin KIF4A
- Kinesin-like protein KIF20A
- Kinesin-like protein KIFC1
- Microtubule-associated protein RP/EB family member 1
- Kinesin-like protein KIF15
- Kinesin-like protein KIF11
- Holliday junction recognition protein
- Kinesin-like protein KIF23
Sequence:
MAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPPEHQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQYSLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESIPVPSPLCPEPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWPMEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAPVPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSNRRNGKDLIRVGRALSAGNGVTKVS
Protein: Multidrug resistance protein MdtN (P32716)
Organism: Escherichia coli (strain K12)
Function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Multidrug resistance protein MdtO
- Multidrug resistance outer membrane protein MdtP
- Uncharacterized protein YtcA
- Outer membrane protein TolC
- RNA-binding protein Hfq
- Multidrug export protein EmrB
- Macrolide export ATP-binding/permease protein MacB
- Probable multidrug resistance protein EmrY
- Linear primary-alkylsulfatase
Sequence:
MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ
Protein: Core histone macro-H2A (Q4V914)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037942}. Chromosome {ECO:0000256|PIRNR:PIRNR037942}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase
- Histone H2B 3
- Histone H2A deubiquitinase MYSM1
- Histone H2B
- Cytokine-like nuclear factor N-PAC
Sequence:
MSARGGKKKITKLSRSARAGVIFPVGRMMRYLRTGTHKYRIGMGAPVYMAAVIEYLAAEILELAGNAARDNKKGRITPRHIKLAVANDEELNQLLRGVTISNGGVLPRIHPELLSKKRGGKVKVESQVAVPEKSAKRKPVKKPYKKSKGKPGRKPKKSTENDKEADANAMEDGPGEGFTILSAKSLFLGQKLSLTESEISKIGTIKVEGIINPTNAEIDLKEGIGNALEKTGGKDFLETVKELRKSQGPLEVASVAVSQANGMAARFIIHCHVPQWGSDKCEDQLEKTVKNCLSAAEEKKLKSVAFPSLPAGRNGFPKQTAAQLILKAISNHFVSATTSSLKNIYFVLFDSESIGIYLQEMAKMDAK
Protein: UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) (P9WQK7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
Interaction partners:
- UvrABC system protein B
- UvrABC system protein C
- Transcription-repair-coupling factor
- ATP-dependent DNA helicase UvrD1
- Protein RecA
- DNA repair protein RecN
- Holliday junction branch migration complex subunit RuvB
- ATP-dependent DNA helicase UvrD2
- LexA repressor
- Holliday junction branch migration complex subunit RuvA
Sequence:
MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFLVLAPVVRTRKGEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHDIEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVDHELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELVVPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAKARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQMKERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELSIADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRDLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKDSITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLVRVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVSEVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVIVIEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFLAEVVGGGASAATSRSNRRRNVSA
Protein: Coagulation factor V (Activated protein C cofactor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] (O88783)
Organism: Mus musculus (Mouse)
Function: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Prothrombin
- Coagulation factor X
- Vitamin K-dependent protein S
- Vitamin K-dependent protein C
- Coagulation factor VIII
- Protein ERGIC-53
- Glia-derived nexin
- Antithrombin-III
Sequence:
MLLVCPCFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWNYHPEPTDPSLNSIPSFKKIVYREYEQYFKKEKPRSSNSGLLGPTLYAEVGDVIKVHFRNKADKPLSIHPQGIKYSKFSEGASYADHTFPAERKDDAVAPGEEYTYEWIVSEDSGPTPDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSRSQSPSLMYTINGFVNKTMPDITVCAHDHVSWHLIGMSSGPELFSIHFNGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGRWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSPKTLTREQRRYMKRWEYFIAAEEVIWNYAPVIPANMDKIYRSQHLDNFSNQIGKHYKKVIYRQYEEETFTKRTDNPSIKQSGILGPVIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDGINSSSTSGSHTTIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIGLLLICKSRSLDQRGVQRVADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESISTLGFCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRRHEDTLTLFPMRGESVTVTMDNVGTWMLTTMNSNPKRRNLRLRFRDVKCNRDYDNEDSYEIYEPPAPTSMTTRRIHDSLENEFGIDNEDDDYQYLLASSLGIRSFKNSSLNPEENEFNLTALALENSSEFISPSTDRVVDSNSSRILSKIINNNLKDFQRTLPGSGATVAGTLLRNLIGLDENFVLNSSTEHRSSSYHENDMENPQSNITMVYLLPLGPKGSGNREQDKPKTIKTGRPHMMKHRFSWMKAPAGKTGRHSNPKNSYSGMKSEEDIPSELIPLKQKITSKFLNRRWRVASEKGSYEIIAANGEDTDVDKLTNSPQNQNITVPRGESTSHTNTTRKPSDLPTFSGVGHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSPRGFDPLRGHNHSPFPDRRLLNHSLLLHKSNETALSPDLNQTSPSMSTDRSLPDYNQYSKNDTEQMSSSLDLYQSVPAEEHSPTFPAQDPDQTHSTTDPSYRSSPPELSQGLDYDLSHDFYPDDIGLTSFFPDQSQKSSFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQLLLSPEDNQKTSSPDLGQVPLSPDDNQKTSSPDLGQVSLSPDDNQKTSSPDLGQVPLSLDDNQKTTSPDLGQVPLSPDDNQMITSPDLGQVPLSSDNQKTSSPDLGQVPLFPEDNQNYFLDLSQVPLSSDQNQETSSTDLLTLSPDFGQTVLSPDLDQLPLPSDNSQVTVSPDLSLLTLSPDFNEIILAPDLGQVTLSPDLIQTNPALNHGHKASSADPDQASYPPDSGQASSLPELNRTLPHPDLTHIPPPSPSPTLNNTSLSRKFNPLVVVGLSRVDGDDVEIVPSEEPERIDEDYAEDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYLRGHGGHKKFYYIAAEEITWNYAEFAQSEMDHEDTGHTPKDTTYKKVVFRKYLDSTFTSRDPRAEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDESPEWFQEDDAVQPNSSYTYVWHATKRSGPENPGSACRAWAYYSAVNVERDIHSGLIGPLLICRKGTLHMERNLPMDMREFVLLFMVFDEKKSWYYEKSKGSRRIESPEEKNAHKFYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLDNRTKQHQLGVWPLLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDSQIKASEYLTYWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAKHYLKSCFTTEFQVAYSSDQTNWQIFRGKSGKSVMYFTGNSDGSTIKENRLDPPIVARYIRIHPTKSYNRPTLRLELQGCEVNGCSTPLGLEDGRIQDKQITASSFKKSWWGDYWEPSLARLNAQGRVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYVKSYSIQYSDQGVAWKPYRQKSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDIY
Protein: Uncharacterized transporter C1039.04 (Q9US37)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEKSISSISKASMNSDEKLDKKEWDQQLPIDFGEGEDVTTEVYILDHKAERRLCRKFDFRILPLLALLYLFNALDKSNVSNAKTNGMDKDLGFVGDQYNIMISIFYIPFVLCAFPFSYLYKRFGAARILPFFMLSFGAMSLCQAAVKNFGGMMAVRWFLGMAESAVLPGVVYYLTTFYRRTELARRLAIFYAAANVSSAFGGLLAYGVFHIKGGKLQGWQYLFLIEGGVTFLCAIVIFLVLPVSVETANFLTDEEKTLAKMRIENDSSSAISEKLSFKQSLTVFKHPIAILWLLEEMALGVPLNSINNWLPQIVAAMGFSSVNTNLMTVAPAISGAIWLLVFAFISDFLKNRGIVLIAAISTTMIGFIVYGSIDIMNHIGVSYFACFLMTAGAAASSVLTSTWYNNNTPNESRRAVFTSVGVPLANVMGLVSANIFRPQDAPKYVPALGITAGFGGLGILLVASISVYMFFDNRRRDNAQGVKKTFADVSTKDLGEGPANPNFRWFL