wanglab/gogpt-training-data huggingface dataset:
Protein: Tumor protein 63 (p63) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (O88898)
Organism: Mus musculus (Mouse)
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Subcellular location: Nucleus {ECO:0000269|PubMed:14729569}.
Interaction partners:
- Tumor protein p73
- Keratin, type II cytoskeletal 5
- E3 ubiquitin-protein ligase Mdm2
- Cellular tumor antigen p53
- Keratin, type I cytoskeletal 14
- RelA-associated inhibitor
- Apoptosis-stimulating of p53 protein 2
- Apoptosis-stimulating of p53 protein 1
- Transcription factor SOX-2
- Histone deacetylase 2
Sequence:
MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
Protein: Probable 1,3-beta-glucanosyltransferase GAS3 (EC 2.4.1.-) (Glycolipid-anchored surface protein 3) (Q03655)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:15781460}. Membrane {ECO:0000269|PubMed:15781460}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15781460}. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Interaction partners:
- Deoxyribodipyrimidine photo-lyase, mitochondrial
- Probable family 17 glucosidase SCW4
- Probable family 17 glucosidase SCW10
Sequence:
MQLSKSILLAALAATPSLVNAMLPIHIKNYRFIKPSSATNSESDNEVFFVKGVDYQPGGSSGYDADSDTDILSDPEVCARDAYAFQQLGVNTVRIYSLNPDLNHDKCMTIFNNAGIYAILDVNSGNYGESLNRADPSGTYDSLYLSRVFKFIDAFKNYPNVLGFFSGNEVINDQSDYAKIDPPYIRAVQRDMKQYISKHANRSIPVGYSAADNTDLRLATFKYLQCNSLDGNKVNDDLDISKSDFFGLNTYEWCSGTSSWESSGYDKLNSTFEDAVIPLIFSEYGCNKNTPRTFDEVSEGLYGGLKNVFSGGLVYEYTEEANNYGLVKLDDSGSLTYKDDFVNLESQLKNVSLPTTKESEISSDSIYKCDNSAITNIYSGFGTNNFTLPSQPAEIANMIEYGVNGTNTGKILTDYAVPTTFNYTIKNNKDDTISATISYDKANSLNELDVTATTVAKSASTSQSSSRSLTSSTSPSSSTGSSSSTGSSSASSSSKSKGVGNIVNVSFSQSGYLALFAGLISALL
Protein: Large ribosomal subunit protein bL19m (39S ribosomal protein L19, mitochondrial) (L19mt) (MRP-L19) (Q9D338)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P49406}.
Interaction partners:
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein bS16m
Sequence:
MAASMAESCRASLYLARSVRMARPRLAAFASDACRVCTGPSRFQSTGPSEPGGFKPPPKPVIVDRRRVPEDERRFLSPEFIPPRGRTNPLKFKIERKDMLDRRKVLPIPEFYVGSILRVTTADPYASGKTSQFLGICIKRSGNGLGATFTLRNTIEGQGVEICFELYNPRIQEIQVVKLEKRLDDNLLYLRDALPEYSTFDVNMKPVPQEACQEVPVNKLKVKMKPKPWSKRWERPNFNIKGIRFDLALTEEQMKEAQKWNKPWIEFDMMREYDTSKIEAALWEEIEASKKS
Protein: G-protein coupled receptor 39 (Q5U431)
Organism: Mus musculus (Mouse)
Function: Zn(2+) acts as an agonist (By similarity). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O43194}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43194}.
Interaction partners:
- Appetite-regulating hormone
- Probable proton-coupled zinc antiporter SLC30A3
Sequence:
MASSSGSNHICSRVIDHSHVPEFEVATWIKITLILVYLIIFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFKYKAVSGPRQVKLLIGFVWVTSALVALPLLFAMGIEYPLVNVPTHKGLNCNLSRTRHHDEPGNSNMSICTNLSNRWEVFQSSIFGAFAVYLVVLASVAFMCWNMMKVLMKSKQGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRTYFRAYMILLPFSDTFFYLSSVVNPLLYNVSSQQFRKVFWQVLCCRLTLQHANQEKRQRARFISTKDSTSSARSPLIFLASRRSNSSSRRTNKVFLSTFQTEAKPGEAKPQPLSPESPQTGSETKPAGSTTENSLQEQEV
Protein: Malate dehydrogenase 1, mitochondrial (EC 1.1.1.37) (Mitochondrial MDH1) (mMDH1) (Mitochondrial NAD-dependent malate dehydrogenase 1) (mNAD-MDH 1) (mtNAD-MDH1) (Q9ZP06)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Its activity is essential to shuttle reductants out from the mitochondria to support the photorespiratory flux. Can convert 2-oxoglutarate to (S)-2-hydroxyglutarate in vitro.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Citrate synthase 4, mitochondrial
- NAD-dependent malic enzyme 2, mitochondrial
- Malate synthase
- Citrate synthase 2, peroxisomal
- Citrate synthase 1, peroxisomal
- Citrate synthase 3, peroxisomal
- NAD-dependent malic enzyme 1, mitochondrial
- Citrate synthase 5, mitochondrial
- Fumarate hydratase 2
- Fumarate hydratase 1, mitochondrial
Sequence:
MFRSMLVRSSASAKQAVIRRSFSSGSVPERKVAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSEVVGYMGDDNLAKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLCTAIAKYCPHALINMISNPVNSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRARTFYAGKANVPVAEVNVPVIGGHAGVTILPLFSQATPQANLSSDILTALTKRTQDGGTEVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPDVIECSYVQSTITELPFFASKVRLGKNGVEEVLDLGPLSDFEKEGLEALKPELKSSIEKGVKFANQ
Protein: Lipid A palmitoyltransferase PagP (EC 2.3.1.251) (Lipid A acylation protein) (P37001)
Organism: Escherichia coli (strain K12)
Function: Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. Phosphatidylglycerol (PtdGro), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer) and phosphatidic acid (Ptd-OH) are all effective acyl donors.
Subcellular location: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210}.
Interaction partners:
- Lipid A biosynthesis myristoyltransferase
- Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
- Phosphoethanolamine transferase EptA
- Lipid A 1-diphosphate synthase
- Kdo
- Tetraacyldisaccharide 4'-kinase
- 3-deoxy-D-manno-octulosonic acid transferase
- Phospholipase A1
- Transcriptional regulatory protein PhoP
- Sensor protein PhoQ
Sequence:
MNVSKYVAIFSFVFIQLISVGKVFANADEWMTTFRENIAQTWQQPEHYDLYIPAITWHARFAYDKEKTDRYNERPWGGGFGLSRWDEKGNWHGLYAMAFKDSWNKWEPIAGYGWESTWRPLADENFHLGLGFTAGVTARDNWNYIPLPVLLPLASVGYGPVTFQMTYIPGTYNNGNVYFAWMRFQF
Protein: Cytochrome P450, family 702, subfamily A, polypeptide 5 (A8MS53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- PIF1 helicase
- PIF1 helicase
- PIF1 helicase
- Protein TIFY 4A
- DEAD-box ATP-dependent RNA helicase 8
- Pentatricopeptide repeat-containing protein At5g59600
Sequence:
MVEVYEFWAVIVSLIVVKLCHWIYQWKNPKGNGKLPPGSMGYPIIGETFEFMKLHDAIQLPTFVKEKLLRHGPVFRTSLFGGKVIISTDIGLNMEIAKTNHIPGMPKSLERLFGATNLFVNKDTHKHARSLTNQFLGSQALKLRMIQDIDFLARTHMKEGARKGCLDVKETASKIVIECLSKKVMGEMEPEAAKELTLCWTFFPRDWFRFAWNFPGTGVYRIVKARNRMMKVIKETVVKKRASGKKLGEFFETIFGDTESVTMSIEIATEYIFTLFVLANETTPGVLAATIKLISDNPKVMQELRREHEGIVQDKIKKDETADLTWEDYKSMTFTQMVINESLRITSTVPTVLRIIDHEIQFGDYTIPAGWIFMGYPYVHFNPEKYDDPLAFNPWRWKGKDLSTIVSKTYLPFGSGTRLCVGAEFVKLQMAIFIHHLFRYRWSMKAETTLLRRFILVLPRGSDVQIS
Protein: PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) (Q9UBP9)
Organism: Homo sapiens (Human)
Function: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16497666}. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Interaction partners:
- Intraflagellar transport protein 122 homolog
- Engulfment and cell motility protein 2
- Dedicator of cytokinesis protein 1
- Amyloid-beta precursor protein
- Engulfment and cell motility protein 3
- Prolow-density lipoprotein receptor-related protein 1
- Engulfment and cell motility protein 1
- Multiple epidermal growth factor-like domains protein 10
- Stabilin-2
- Adapter molecule crk
Sequence:
MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC
Protein: Zinc-type alcohol dehydrogenase-like protein C1198.01 (EC 1.-.-.-) (Q9P6I8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Xylulose kinase
- Uncharacterized protein C1683.06c
- Alcohol dehydrogenase 4
- Multifunctional tryptophan biosynthesis protein
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
Sequence:
MEYLTNLKTNIMDKQLGHREVSEGSTQPKPDPSGATMKACVWDGPLNVKIAEVPKPTITHPKDVIVKTTACTICSGSDSHIFSGEMPGIEKGAILGHESCGIVAEKGDEVNNLEIGDRVVIAFDLACGQCSFCKRHEYAACDTTNDSKLMDVNYGSHHSAIFGYTKLLGDVPGCQAEYIRVPFAEINCCKLPDDIPDSEGLFMSDVLCTSLHACTLGEVKKGDTVAIWGMGPIGLYAGRWAQILGASKVIGIEVVPERIELARQKFGFTVIDRNEVSDVPKKIMELVSNGVDCAIEASGFRFSTSILHKVERAVGLETDSPDMITECLNAVRKYGHVSIIADYVGTSNQFPIGHVVMKHLTIRSGQCPCQNYFGYVIDNIRSGKIDPRWMVTNKIKFDDLPDAYNKLFYKEDGYVKVYCDMTE
Protein: Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (F1LM93)
Organism: Rattus norvegicus (Rat)
Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1709169}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:1709169}. Cell junction {ECO:0000250|UniProtKB:Q28923}. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q28923}.
Interaction partners:
- Tyrosine-protein kinase Fyn
- Catenin delta 1
- Tyrosine-protein kinase Fer
- Transcriptional coactivator YAP1
- Receptor protein-tyrosine kinase
- E3 ubiquitin-protein ligase CBL
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Growth factor receptor-bound protein 2
- Signal transducer and activator of transcription 3
- RAC-alpha serine/threonine-protein kinase
Sequence:
MGCIKSKENKSPAIKYTPENPTEPVNTSAGHYGVEHATAATTSSTKGASANFNSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPTSLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGILLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
Protein: Type 3 secretion system needle filament protein (T3SS needle filament protein) (P0A223)
Organism: Shigella flexneri
Function: Necessary for the secretion of IPA invasins.
Subcellular location: Secreted {ECO:0000305}. Cell surface {ECO:0000305}.
Interaction partners:
Sequence:
MSVTVPNDDWTLSSLSETFDDGTQTLQGELTLALDKLAKNPSNPQLLAEYQSKLSEYTLYRNAQSNTVKVIKDVDAAIIQNFR
Protein: Ccc1p (Q59SS1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Mitochondrial thiamine pyrophosphate carrier 1
- Divalent metal ion transporter
- Iron-sulfur assembly protein 1
- Hap43p
- Translation initiation factor RLI1
- Fth1p
- Iron-regulated transcriptional activator AFT2
- Porphobilinogen deaminase
Sequence:
MSLVAIKNGISKLVSSKDASDAELERVERLIDSNQIPYGSTDSNDERAQQLAREEAIIQAAASISAASSSENKEEEGVDSITAFFNTFDPRVMSDIIIGLSDGLTVPFALTAGLSSLGDSKLVITGGMAELVSGAISMGLGGYLAAKSESEYYFSQVKKEKLEFFKKPEAINQDAAEIMFELGASEQTIISFLKDLDAKPKNLIDFVIRYGKGLEEPAAGRELTSALTIGASYFLGGFVPLLPYFFTKEVGTGLIISVVAMLVVLMLFGYFKCSISMGEGCPNHKKFAAGFEMVVVGSIAAGAAWGLVFLIE
Protein: Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) (Q86UT8)
Organism: Homo sapiens (Human)
Function: Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:31722219}. Note=Localizes to the proximal end of the mother centriole. During the cell cycle, from G1 to metaphase, gradually accumulates on the centrosome and then decreased significantly upon entry into anaphase. {ECO:0000269|PubMed:31722219}.
Interaction partners:
- Thioredoxin-like protein 4B
- U4/U6 small nuclear ribonucleoprotein Prp3
- Speckle targeted PIP5K1A-regulated poly
Sequence:
MAPAQRCPLCRQTFFCGRGHVYSRKHQRQLKEALERLLPQVEAARKAIRAAQVERYVPEHERCCWCLCCGCEVREHLSHGNLTVLYGGLLEHLASPEHKKATNKFWWENKAEVQMKEKFLVTPQDYARFKKSMVKGLDSYEEKEDKVIKEMAAQIREVEQSRQEVVRSVLEPQAVPDPEEGSSAPRSWKGMNSQVASSLQQPSNLDLPPAPELDWMETGPSLTFIGHQDIPGVGNIHSGATPPWMIQDEEYIAGNQEIGPSYEEFLKEKEKQKLKKLPPDRVGANFDHSSRTSAGWLPSFGRVWNNGRRWQSRHQFKTEAAAMKKQSHTEKS
Protein: ATP-dependent RNA helicase rok1 (EC 3.6.4.13) (Q09775)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- rRNA biogenesis protein rrp5
- Uncharacterized protein C3B8.09
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 22
- Probable nucleolar complex protein 14
- Putative ATP-dependent RNA helicase PB1A10.06c
- rRNA-processing protein fcf1
- Ribosomal RNA-processing protein 7
- Protein sof1
- Probable U3 small nucleolar RNA-associated protein 7
Sequence:
MDALKLLTTNVKFKNKVPQPSIKEKEAKKLQGITKGKAKVTGNNPVDPIEEFPEGILCENLKKQNITECTTIQRYAIPTIGSKRDLLACAPTGSGKTIAYLFPILQKLQLHVPGGYRAIIVAPTRELCEQIYRQAEKLSFGTSLKIIELSKSNEKIQEKAPKLREKYDMCIGTPMRLVQAIQTGLSFEKVEFFVMDEADRLFEPGFIEQTDHILSACTSSNICKSLFSATIPSRVEELAKVVTVDPIRIIVGLKDAATDSIDQRLLFVGSDTSKIVILRQMISNGELKPRVVIFVQDIERAKALYTELLFDEIHVGVIHGELPQAKREEALAKFRKGEIWVLIATDLLARGIDFHGVKMVINFDFPQSVHSYIHRIGRTGRAGNTGQAVTFFTKEDGEYIKLIAGVMRSSGCEVPNWVMALPKPSKEMKKKLKKSPPKRKRITTRASYDRQKEQRKKEYIKKVKKEASIKKHNEATGDSGQ
Protein: Non-neuronal cytoplasmic intermediate filament protein A (IFA) (P16274)
Organism: Helix pomatia (Roman snail) (Edible snail)
Function: Epithelial intermediate filament protein.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
TSKISTTYEEEGRQSKIQPRAFVITRSGPTSRSSSYSARQSYGSRSSITPGVYQQLSSSGITDFRGTREKEKREMQNLNERLAGYIEKVHFLDAQVKKLEAENXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMDYAEFWKSELSKCVRDIQSAYDEKIDIIXXXXXXXXXXXXXXXXXXXXXXXMQLQHVQEEVKKLRTQAGEKNAAYAEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMELEIACYRKLLEGEESRVGLRSLVEQAIGVQGRGTASLKDTIQQSTASGSMTVQRSSKGPIAFNSVDQSGSNIVIENTTSGARAKTQSLKGWRVDKTVAGRVAASIELKNYDLPPNTKYTIWAKGAKDRATADNEQIADMFSLGVG
Protein: Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3) (O88944)
Organism: Rattus norvegicus (Rat)
Function: Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9836639}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 2
- Potassium voltage-gated channel subfamily Q member 5
- Potassium voltage-gated channel subfamily KQT member 1
- Inward rectifier potassium channel 4
- ATP-sensitive inward rectifier potassium channel 12
- Potassium voltage-gated channel subfamily KQT member 4
- Inward rectifier potassium channel 2
- ATP-sensitive inward rectifier potassium channel 14
- Ubiquitin-like protein FUBI
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
Sequence:
MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGTGADKDGTLLLEGGGREEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRLDLVATWRFYESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMTEDRGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPRNEPYVARAATSETEDQSMMGKFVKVERQVHDMGKKLDFLVDMHMQHMERLQVHVTEYYPTKGASSPAEGEKKEDNRYSDLKTIICNYSESGPPDPPYSFHQVPIDRVGPYGFFAHDPVKLTRGGPSSTKAQANLPSSGSTYAERPTVLPILTLLDSCVSYHSQTELQGPYSDHISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPSGGSSWMREKRYLAEGETDTDTDPFTPSGSMPMSSTGDGISDSIWTPSNKPT
Protein: Peroxidase (EC 1.11.1.7) (Q5K4K5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU362060}.
Interaction partners:
Sequence:
MQKGSTQIALILASLIISNIVVLVVSQGQLRVGFYSKSCPNAEPIIRKVVQKAVADNPRNAAILLRLHFHDCFVQGCDGSILIRNDEDGELKAQGNLGVVGFDIIDSAKARLENLCPGIVSCADIVSLAARDAVSLVNGPFYDVPTGRRDGRVSKMSLAKNLPDVDDSINVLKSKFKEKGLSDKDLVLLSGGSHTIGATACFFMQKRLYNFTPGGGSDPAINPGFLPQLKDKCPFNGDVNVRIPLDWSTQNVFDVKILRNIREGNAVIASDARLYDDRMTRQIVDSYITSSAASFNQDFAEAMVKMGNIGAKTGSEGEIRRACNAVN
Protein: Sidestep, isoform D (A0A0B4K6K0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MQLLLPTSGMPTNTLETETPAMQTTYWPRQTGNSKSKSNTNCKCNINTHRKSRTRCPDNGKTIWAVGFTLVLLTCLQQLKSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFREGYELFLCCQVRGGRPPPKVTWWRDDTELIGTSHTSVEEGATVMVNQLLIGTTTRDFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCESWGSYPAAKITWLLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSENDNAELTCRATNPWFSGGAIEDKRIIRVAYPPTVSVHLANEDPSRLVTRAEGQNVTFKCRADARPPVTSYSWFKNGMRMSGESTEIMHLTQLERESAGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAVSLHSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSELITLACWASNAVGRQTTPCLVHILPANTPEAPKACELRNDTVLEVVCVAGSDGGLSQYFMLEVVGGDPLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSAPIFRMQENSPQFRLNNLEPGREYQFLVYAVNAKGRSEPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGGVGGSGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTSIIVAGIVVVCRHRPRPPEPQEVRKSMRPARNDVPSMYIEEDELNELEEGGGRAADIRARVAPPNSHLCGGGGMPMPGGVGSSGGAIVGVAGPHHYISESFIQYAQPSLNVYIADPDLILPRGELEFTTLDPTLK
Protein: X antigen family member 1 (XAGE-1) (Cancer/testis antigen 12.1) (CT12.1) (G antigen family D member 2) (Q9HD64)
Organism: Homo sapiens (Human)
Interaction partners:
- X antigen family member 3
- X antigen family member 2
- Melanoma-associated antigen C1
Sequence:
MESPKKKNQQLKVGILHLGSRQKKIRIQLRSQCATWKVICKSCISQTPGINLDLGSGVKVKIIPKEEHCKMPEAGEEQPQV