wanglab/gogpt-training-data huggingface dataset:
Protein: NADPH-dependent codeinone reductase 1-1 (PsCor1.1) (EC 1.1.1.247) (Q9SQ70)
Organism: Papaver somniferum (Opium poppy)
Function: Reduces codeinone to codeine in the penultimate step in morphine biosynthesis. Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11079569}. Note=Present in the cytosolic part of laticifer cells that secrete latex (PubMed:11079569). Localized to the parietal region of the sieve element cytoplasm (PubMed:14508000). {ECO:0000269|PubMed:11079569, ECO:0000269|PubMed:14508000}.
Interaction partners:
Sequence:
MESNGVPMITLSSGIRMPALGMGTAETMVKGTEREKLAFLKAIEVGYRHFDTAAAYQSEECLGEAIAEALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLDYLDLYLIHHPVSLKPGKFVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVCNFSCKRLQELMETANSPPVVNQVEMSPTLHQKNLREYCKANNIMITAHSVLGAVGAAWGTNAVMHSKVLHQIAVARGKSVAQVSMRWVYQQGASLVVKSFNEARMKENLKIFDWELTAEDMEKISEIPQSRTSSAAFLLSPTGPFKTEEEFWDEKD
Protein: Tryptophan synthase (EC 4.2.1.20) (Q5AZP9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Multifunctional tryptophan biosynthesis protein
- tryptophan synthase
- thioredoxin-dependent peroxiredoxin
- Anthranilate phosphoribosyltransferase, hypothetical
- Histidinol dehydrogenase
- Histidine biosynthesis trifunctional protein
- anthranilate synthase
- Chorismate synthase
- Alpha/beta hydrolase, putative
- aminodeoxychorismate synthase
Sequence:
MEHIKNTFEKVKREKRAALVAYITAGYPTIEESVDILLGLENGGADIIELGVPFTDPIADGPTIQKANTKALANGVTVSTVLEMVRSARNRGLKAPIMLMGYYNPMLSYGEERMLRDCKEVGVNGFIMVDLPPEEAVRFRDLCTSTGLSYVPLIAPATSESRMKLLCKIADSFIYVVSRMGVTGATGTLSSNIPELLARVHKWSGNVPTALGFGVSTREHFLSVQEISEGVVIGSQIITVLGEAPAGQAAQKAEEYLSSVTGRKLERDTSGALTREVNVLEPVLKIETPPMSQPTDVITEKDTPSGPGLGDQLEALNGGGSSSATPARFGEFGGQYVPESLMDCLAELERGFDSALKDPSFWEEYRSYYPYMGRPSSLHLATRLTEHVGGANIWLKREDLNHTGSHKINNALGQILLARRLGKTRIIAETGAGQHGVATATVCAKFGMKCVVYMGAEDVRRQALNVFRMKLLGASVVAVDAGSRTLRDAVNEALRAWVVDLDTTHYIIGSAIGPHPFPTIVRTFQSVIGEETKQQLQEQIGKLPDAVVACVGGGSNAVGSFYPFSKDTSVKLLGVEAGGDGIDTNRHSATLSGGSKGVLHGVRTYILQDEHGQVSETHSISAGLDYPGVGPELSNWKDSDRAHFIAATDAQALSGFRTMAQTEGIIPALESSHAIWGAIELAKTMGKGKDIVLTVSGRGDKDVESVAESLPKLGPQIGWDLRF
Protein: Gap junction protein (Q8JFD2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
- Beta-crystallin B2
- Beta A1-crystallin
- Crystallin, beta B1
- Beaded filament structural protein 2, phakinin
- Alpha-crystallin A chain
- Beaded filament structural protein 1.
- Beta-crystallin B3
- Beta-crystallin A4
- Alpha-crystallin B chain
Sequence:
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDEAFPISHIRFWVLQIIFVSTPTLIYLGHVLHIVRMEEKRKEREEELRKASRLQEEKELLYRNGGGGEPGGRGGGGKKEKPPIRDEHGKIRIRGALLRTYVFNIIFKTLFEVGFILGQYFLYGFQLRPLYKCARWPCPNTVDCFISRPTEKTIFIIFMLVVACVSLLLNLLEIYHLGWKKVKQGMTNEFAPDRESLPEADEAEPESPRTAPPTLSYPPDYTEVAVAGGAFLQPVSAPSTAEFKMDPLREELEESSPFYISNNNNHRLAAEQNWANLATEQQTREMNATSPCSSSSSCSSDNVRQSKDAAQLASTPSSAGGGLSTGPEEGHVTTTVEMHEPPVIFTDARRLSRASKASSVRARPNDLAV
Protein: DNA polymerase (EC 2.7.7.7) (M0R2B7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000442}.
Interaction partners:
Sequence:
MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRGSVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPPEGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGVRPQDRAGAAWELLALTPGRGCSPPRYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW
Protein: Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG) (Q16515)
Organism: Homo sapiens (Human)
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:8626462}; Multi-pass membrane protein {ECO:0000269|Ref.10}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250|UniProtKB:Q925H0}.
Interaction partners:
- Acid-sensing ion channel 1
- Stomatin
- PRKCA-binding protein
- Acid-sensing ion channel 3
- Stomatin-like protein 3
- Disks large homolog 4
- Acid-sensing ion channel 4
Sequence:
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
Protein: D-serine/D-alanine/glycine transporter (Amino acid carrier CycA) (P0AAE0)
Organism: Escherichia coli (strain K12)
Function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine, glycine and beta-alanine. Also contributes to L-alanine uptake. In addition, in minimal media, transports the broad spectrum antibiotic D-cycloserine into the cell. Transports D-cycloserine only in minimal media, and not in a complex medium, suggesting that CycA does not play a role in D-cycloserine transport when E.coli is grown in a complex or biologically relevant medium, probably due to competition from other CycA substrates present in the medium.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Serine/threonine transporter SstT
- D-serine transporter DsdX
Sequence:
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKDPEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCWVCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
Protein: Segregation and condensation protein B (Q8DNI9)
Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Function: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01804}. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells. {ECO:0000255|HAMAP-Rule:MF_01804}.
Interaction partners:
- Segregation and condensation protein A
- Lipoprotein
- Pseudouridine synthase
- Chromosome partition protein Smc
- Putative membrane protein insertion efficiency factor
- dITP/XTP pyrophosphatase
- Phosphoesterase
- Glutamate racemase
- Tyrosine recombinase XerD-like
- CBS domain-containing protein
Sequence:
MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
Protein: CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Q38FY6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phosphatidate cytidylyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Inositol-1-monophosphatase
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4-kinase
- phosphatidylinositol 3-kinase
- Phosphoinositide phospholipase C
- 1-phosphatidylinositol-3-phosphate 5-kinase
- non-specific serine/threonine protein kinase
- phosphatidylinositol N-acetylglucosaminyltransferase
Sequence:
MPKAKTTTPLQVCLFYPNLIGYTRVILSLISFCLLGHFPIAFLFCYIIGFVLDAVDGMVARRFGQCTQFGAILDMLTDRASTAGLIVVVVQVLQPLPHWGATSLACLVFLDISSHFCVMYVSLYAGRTSHKDVSSSIFSLLRLYYTNRPFMCALCVGQELFYLNLYMYGVYGIAEPAFLFFMALTAALSAFKQVVNVQQLLDSMYHLAVLDAAGSRQ
Protein: UPF0641 membrane protein PJ4664.05 (Q96WV4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSSAISRSRFNSFILHTVATANLIWAFNWINHNSDVAIRRSYGSHFQHLTVLSLAVTLLSMVVGLFSDISGSLTLVKLKNILLYIVCPLETIVSILYWSIVSYDRSLLIPKDRPVPLPLNFDISVHLMPTVYTLIDYLFFSPPFSLSIGPSLLVYLSIAVSYMLWVEKCYQMNKFYAYPILAILDPIKKTIFYTVASIISFSCYIVLKMVHPYALPSGAPPRS
Protein: ETS translocation variant 4 (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) (Q9PUQ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Nuclear receptor coactivator 3
- Sprouty homolog 4
- Fibroblast growth factor 8
- Dual specificity protein phosphatase
- Fibroblast growth factor
- Fibroblast growth factor 3
- Fibroblast growth factor receptor 1-A
Sequence:
MDYKMDGYLDQQVPYTLANRSQGNGPLNRLLMATKRKYMDAELPPQESEDLFQDLSQLQETWLTEAQVPDSDEQFVPDFHSENSVAFHSPPVKIKKEPQSPGSDPSQSCSHKQSFSYPNGEQCLYASAYEQKRAAVAGAGGSKSSCPATPMSPMQHYSPKPTVGTRQESGYMNPPSSSQSHACHSHSYPMNPSSRFPSGSAEMCPPFASQGQALQRIDPAHASGGGGGGYHRQHSDPCLPYPPQQTFKQEYMDPLYDRAAHINGPQPQRFPPAHMMVKQEPTDYTYEPDVPGCPSMYHHNEGYSNPQHNSEGYMFENDSRVVPEKFEGEVKQEGGSVFREGAPYQRRGSLQLWQFLVALLDDPSNAHFIAWTGRGMEFKLIEPEEVARLWGIEKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALITLAFPDNQRPSLKAEFERYVNEEDTVPLSHLDEGVSYPPEPAATNMGPQPYSKGYMY
Protein: Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] (Q8BSF4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity).
Subcellular location: [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}.; SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}. Cytoplasm {ECO:0000250|UniProtKB:Q9UG56}. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. {ECO:0000255|HAMAP-Rule:MF_03208}.; SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UG56}. Lipid droplet {ECO:0000250|UniProtKB:Q9UG56}. Note=Predominantly localizes to lipid droplets in lipid-replete conditions, and to mitochondria in lipid-deplete conditions. {ECO:0000250|UniProtKB:Q9UG56}.
Interaction partners:
- Phosphatidylethanolamine N-methyltransferase
- Phosphatidylserine synthase 2
- Phosphatidylserine synthase 1
- Choline/ethanolaminephosphotransferase 1
- Ethanolaminephosphotransferase 1
- Membrane-bound glycerophospholipid O-acyltransferase 2
- Phospholipase D1
- Phospholipase D2
- Phospholipase A1 member A
- Lysophospholipid acyltransferase LPCAT4
Sequence:
MAASGGRACVRSLRGGVLWRSSPCHYESTATRHFLGTLQKLPLQAGVRNFHTAPVRSLFLLRPVPILLATGGGYAGYRQYEKYRERKLEKLGLEIPPKLASHWEVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDLPFPPASSSDSFRNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPRYSKGSYNDLSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFGEALGSL
Protein: Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (AtG6PD1) (G6PDH1) (EC 1.1.1.49) (Q43727)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:21309870}. Peroxisome {ECO:0000269|PubMed:21309870}.
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic
- Probable 6-phosphogluconolactonase 1
- 6-phosphogluconolactonase 3, chloroplastic
- Probable 6-phosphogluconolactonase 2
- Probable 6-phosphogluconolactonase 4
- Probable 6-phosphogluconolactonase 5
Sequence:
MATHSMIIPSPSSSSSSLATAASPFKETLPLFSRSLTFPRKSLFSQVRLRFFAEKHSQLDTSNGCATNFASLQDSGDQLTEEHVTKGESTLSITVVGASGDLAKKKIFPALFALFYEGCLPQDFSVFGYARTKLTHEELRDMISSTLTCRIDQREKCGDKMEQFLKRCFYHSGQYNSEEDFAELNKKLKEKEAGKISNRLYYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDQYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRSEKVKVLRSMKPLRLEDVVVGQYKGHNKGGKTYPGYTDDPTVPNHSLTPTFAAAAMFINNARWDGVPFLMKAGKALHTRGAEIRVQFRHVPGNLYKKSFATNLDNATNELVIRVQPDEGIYLRINNKVPGLGMRLDRSDLNLLYRSRYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWDLFTPALKELEEKKIIPELYPYGSRGPVGAHYLASKYNVRWGDLGEA
Protein: Transmembrane and coiled-coil domain-containing protein 5A (Q8N6Q1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:D3ZNV2}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:D3ZNV2}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein FAM209A
Sequence:
MEISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQETLKKIEEELEALFLEREVSKLVSMNPVEKEHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLSYMFFHVRFINPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLPH
Protein: Enkurin domain-containing protein (Q385T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Cilia- and flagella-associated protein 45
- Uncharacterized protein
- Uncharacterized protein
- CFA20 domain-containing protein
- Uncharacterized protein
Sequence:
MSGESVFNLIEPDVESVQPQPLRKVKLGKGTAAPPTASTFGFHGTSAVVANVGGENTEPSVHPAKKPTGTFGREASSSVNPSKFLKKNEGVGTASRGVPIVDATKFVKAEKDASKRKDDVPNRYDKPVMGVKTEKNYVVANAVENVLALPTKCIPTPMNRAVDRADFGKVPKYLKEVKADIEERHALVERLKAAKREAEERWSELSGEELEQLKQGLQRRWDSLNKDYQSRGFSKLQTPSQKAQHEAVGKELNAVEFAMQKLSRAHVFVYDDRN
Protein: CLAVATA3/ESR (CLE)-related protein 20 [Cleaved into: CLE20p] (Q3EDI6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular location: [CLE20p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- CLAVATA3/ESR
- Putative F-box protein At1g47915
- Receptor-like protein CLAVATA2
- CLAVATA3/ESR
- Putative B3 domain-containing protein At1g05615
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- Putative defensin-like protein 228
- CLAVATA3/ESR
Sequence:
MKNKNMNPSRPRLLCLIVFLFLVIVLSKASRIHVERRRFSSKPSGENREFLPSQPTFPVVDAGEILPDKRKVKTGSNPLHNKR
Protein: Vesicle transport v-SNARE 12 (AtVTI12) (Protein ZIG SUPPRESSOR 1) (Vesicle soluble NSF attachment protein receptor VTI1b) (AtVTI1b) (Vesicle transport v-SNARE protein VTI1b) (Q9SEL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with either SYP41 or SYP61, required for membrane fusion; the fusion of phospholipid vesicles containing SYP41 or SYP61 and VTI12 is triggered by YKT61 and YKT62. Functions as a v-SNARE responsible for the docking or fusion of transport vesicles within the trans-Golgi network (TGN) and mediates liposome fusion. Necessary to deliver proteins to the protein storage vacuole (PSV). May be also involved in retrograde traffic to the cis-Golgi (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15342965, ECO:0000269|PubMed:15797025, ECO:0000269|PubMed:17277094}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17277094}. Prevacuolar compartment membrane {ECO:0000269|PubMed:15797025, ECO:0000269|PubMed:17277094}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17277094}. Cell membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000255}. Note=Accumulates in structural sterols-containing apical and subapical compartments of developing root hairs tips. {ECO:0000269|PubMed:20841426}.
Interaction partners:
- Tlg2p-like protein a
- Syntaxin-61
- Vacuolar protein sorting-associated protein 45 homolog
- Syntaxin-42
- Syntaxin-51
- VAMP-like protein YKT62
- VAMP-like protein YKT61
- Syntaxin-52
- Syntaxin-43
- Syntaxin-32
Sequence:
MSDVFEGYERQYCELSTNLSRKCHSASVLSNGEEKKGKIAEIKSGIDEADVLIRKMDLEARSLQPSAKAVCLSKLREYKSDLNQLKKEFKRVSSADAKPSSREELMESGMADLHAVSADQRGRLAMSVERLDQSSDRIRESRRLMLETEEVGISIVQDLSQQRQTLLHAHNKLHGVDDAIDKSKKVLTAMSRRMTRNKWIITSVIVALVLAIILIISYKLSH
Protein: GTP binding protein (R-RAS related) (R-ras1 homolog) (G5EBK8)
Organism: Caenorhabditis elegans
Interaction partners:
- Son of sevenless homolog
- Rap guanine nucleotide exchange factor
- GTP binding protein
- Ras protein let-60
- Protein shank
- Kinase suppressor of Ras A
Sequence:
MGGRSNSATTAAQQNAVLRIVVVGGGGVGKSALTIQFIQRYFVQDYDPTIEDSYTKQCFVDEDLCKLEILDTAGQEEFSTMREQYLRTGSGFLIVFAVTDRNSFEEVKKLHELICRIKDRDDFPIILVGNKADLENERHVARHEAEELAHRLSIPYLECSAKIRKNVDEAFFDIVRLVRKYQHDERMPIHPHDDRKLESPIKLKKKKNCRIQ
Protein: Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (Q32PX7)
Organism: Rattus norvegicus (Rat)
Function: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Poly
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Serine and arginine rich splicing factor 11
- RCG33491, isoform CRA_b
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Sequence:
MADYSTVPPPSSGSAGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVPPQNDSFGAQLPPMHQQQRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPDRIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGPVNPLGPPVPHGPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHGPPAPYAPQGWGNAYPHWQQQAPPDPAKAGTDPNSAAWAAYYAHYYQQQAQPPPAAPAGAPTTTQTNGQGDQQNPAPAGQVDYTKAWEEYYKKMGQAVPAPAGAPPGGQPDYSAAWAEYYRQQAAYYAQTSPQGMPQHPPAPQGQ
Protein: BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) (Q7Z569)
Organism: Homo sapiens (Human)
Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9497340}.
Interaction partners:
- Breast cancer type 1 susceptibility protein
- Kinase suppressor of Ras 1
- Polyubiquitin-B
- GTPase HRas
- GTPase NRas
- Kinase suppressor of Ras 2
- Ras-related protein M-Ras
- GTPase KRas
- Ras-related protein R-Ras
- Ras-related protein R-Ras2
Sequence:
MSVSLVVIRLELAEHSPVPAGFGFSAAAGEMSDEEIKKTTLASAVACLEGKSPGEKVAIIHQHLGRREMTDVIIETMKSNPDELKTTVEERKSSEASPTAQRSKDHSKECINAAPDSPSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCILTVPAAMTSHDLMKFVAPFNEVIEQMKIIRDSTPNQYMVLIKFRAQADADSFYMTCNGRQFNSIEDDVCQLVYVERAEVLKSEDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQRIYWENKIVRIEKDTAEEINNMKTKFKETIEKCDNLEHKLNDLLKEKQSVERKCTQLNTKVAKLTNELKEEQEMNKCLRANQVLLQNKLKEEERVLKETCDQKDLQITEIQEQLRDVMFYLETQQKINHLPAETRQEIQEGQINIAMASASSPASSGGSGKLPSRKGRSKRGK
Protein: Pre-mRNA-splicing factor BUD31 (Bud site selection protein 31) (Complexed with CEF1 protein 14) (P25337)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. Important for bud site selection.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing factor CWC15
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor 18
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor CWC22
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor SNU114
Sequence:
MPRIKTRRSKPAPDGFEKIKPTLTDFEIQLRDAQKDKSSKLAAKSNEQLWEIMQLHHQRSRYIYTLYYKRKAISKDLYDWLIKEKYADKLLIAKWRKTGYEKLCCLRCIQKNETNNGSTCICRVPRAQLEEEARKKGTQVSFHQCVHCGCRGCASTD