wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) (P17097)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEVVTFGDVAVHFSREEWQCLDPGQRALYREVMLENHSSVAGLAGFLVFKPELISRLEQGEEPWVLDLQGAEGTEAPRTSKTDSTIRTENEQACEDMDILKSESYGTVVRISPQDFPQNPGFGDVSDSEVWLDSHLGSPGLKVTGFTFQNNCLNEETVVPKTFTKDAPQGCKELGSSGLDCQPLESQGESAEGMSQRCEECGKGIRATSDIALHWEINTQKISRCQECQKKLSDCLQGKHTNNCHGEKPYECAECGKVFRLCSQLNQHQRIHTGEKPFKCTECGKAFRLSSKLIQHQRIHTGEKPYRCEECGKAFGQSSSLIHHQRIHTGERPYGCRECGKAFSQQSQLVRHQRTHTGERPYPCKECGKAFSQSSTLAQHQRMHTGEKAQILKASDSPSLVAHQRIHAVEKPFKCDECGKAFRWISRLSQHQLIHTGEKPYKCNKCTKAFGCSSRLIRHQRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTGEKPYVCNDCGKAFSQSSSLIYHQRIHKGEKPYECLQCGKAFSMSTQLTIHQRVHTGERPYKCNECGKAFSQNSTLFQHQIIHAGVKPYECSECGKAFSRSSYLIEHQRIHTRAQWFYEYGNALEGSTFVSRKKVNTIKKLHQCEDCEKIFRWRSHLIIHQRIHTGEKPYKCNDCGKAFNRSSRLTQHQKIHMG
Protein: Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) (Q13137)
Organism: Homo sapiens (Human)
Function: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:9230084}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17635994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25771791}; Peripheral membrane protein {ECO:0000305}. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:7540613, ECO:0000269|PubMed:9230084}.
Interaction partners:
- RB1-inducible coiled-coil protein 1
- Microtubule-associated protein 1 light chain 3 gamma
- Galectin-8
- Gamma-aminobutyric acid receptor-associated protein-like 2
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein
- Optineurin
- TANK-binding kinase 1-binding protein 1
- Serine/threonine-protein kinase TBK1
- Sequestosome-1
Sequence:
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
Protein: Interferon gamma receptor 1 (F7FHZ1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGPQAAVGRMILLVVLMLSAEIGSGALMSTEDPKPPSVPAPTNVLITSYDLNPVVHWKHQNVSQAAVFTVQVKMYPDNWTDACTNIAHHYCNIYKHISYPDSSAWARVKAKVGQRESAYAQSEEFIMCRKGKVGPPGLDIGRKEDQLIVHIFHPKVNVSQETMFGDGNTCYTFDYTVFVKHYRSGEILHTEHSVLKEDCSETLCELNISVSTLNSNYCVSVVGKSSFWQVNTETSKDACIPFLHDDREESIWMLLVAPLLFLTIVVPALVCCYIKKNPFKRKSIMLPKSLLSVVKNATSETKPESKYSLVTSCQPAVLENETVICEEHLSTVTTPDSLEAPEQEELSKGTVATVAEGNTSPETTDSPPTPVQSGHFSLSSSNQSGSCSLTTYHSRDGSDSGLVGTGSSISDSDFLPNNDSETKMADPAPTPVRKALTFSGYDKPHVLVDVPVDGEGKESLIGYRLTGDTQELS
Protein: Beta-glucosidase 8 (Os3bglu8) (EC 3.2.1.21) (Q75I94)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes p-nitrophenyl beta-D-glucoside, p-nitrophenyl beta-D-mannoside, p-nitrophenyl beta-D-galactoside, p-nitrophenyl beta-D-xyloside, p-nitrophenyl beta-D-fucoside, p-nitrophenyl beta-L-arabinoside, cello-oligosaccharides, laminari-oligosaccharides, sophorose and gentiobiose.
Interaction partners:
- Os01g0542000 protein.
Sequence:
MGCAPAAHYLPGGGWRRLLVVVVALVVLDRAGARVRAADDDTGGLSRAAFPKGFVFGTATSAFQVEGMAASGGRGPSIWDPFVHTPGNIAGNGNADVTTDEYHRYKEDVDLLKSLNFDAYRFSISWSRIFPDGEGKVNTEGVAYYNNLIDYVIKQGLIPYVNLNHYDLPLALQKKYEGWLSPKIVGVFSDYAEFCFKTYGDRVKNWFTFNEPRIVAALGHDTGTDPPNRCTKCAAGGNSATEPYIVAHNIILSHATAVDRYRNKFQASQKGKIGIVLDFNWYEPLTNSTEDQAAAQRARDFHVGWFLDPLINGQYPKNMRDIVKERLPTFTPEQAKLVKGSADYFGINQYTANYMADQPAPQQAATSYSSDWHVSFIFQRNGVPIGQQANSNWLYIVPTGMYGAVNYIKEKYNNPTIIISENGMDQSGNLTREEFLHDTERIEFYKNYLTELKKAIDDGANVVAYFAWSLLDNFEWLSGYTSKFGIVYVDFTTLKRYPKDSANWFKNMLQASGPGSKSGSGTSDSQVGSATSASHPVGSAISSSHRLLLPLLVSLHFLFPSFFMFLSL
Protein: Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (FKBP65RS) (Rotamase) (Q9Z247)
Organism: Mus musculus (Mouse)
Function: PPIases accelerate the folding of proteins during protein synthesis.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10524204}.
Interaction partners:
Sequence:
MALGARGWRRRSLLLLLLWVTGQAAPVLGLAVSSELQIQQSFVPDECPRTVHSGDFVRYHYVGTFLDGQKFDSSYDRDSTFNVFVGKGQLIAGMDQALVGMCVNERRLVTIPPNLAYGSEGVSGVIPPNSVLHFDVLLVDIWNSEDQVHIQTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITVPPFLAYGEEGDGKDIPGQASLVFDVALLDLHNPKDTISIENKVVPENCERRSQSGDFLRYHYNGTLLDGTLFDSSYSRNHTFDTYIGQGYVIPGMDEGLLGVCIGERRRIVVPPHLGYGEKGRGSIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVSGLPEGYMFIWNGEVSPNLFEEIDRDGNGEVLLEEFSEYIHAQVATGKGKLAPGFNAEMIVKNMFTNQDRNGDGKVTAEEFKLKDQEAKHDEL
Protein: Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (Q9XVP0)
Organism: Caenorhabditis elegans
Function: Negatively regulates lifespan.
Interaction partners:
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein eL20
- Plectin/eS10 N-terminal domain-containing protein
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein eL39
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL6
Sequence:
MATQDDAHLAELKKKRTFRKFMYRGVDLDQLLDMSREQFTKLLPCRMRRRLDRGLKRKHLALIAKVQKAKKAAGVLEKPATVKTHLRDMIILPELVGGVIGIYNGKVFNQTEIKPEMIGFYLGEFAISYKPVKHGRPGIGATHSSRFIPLK
Protein: Cuticle collagen lon-3 (Q23628)
Organism: Caenorhabditis elegans
Function: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape.
Interaction partners:
- Cuticle collagen sqt-1
- Protein lon-1
- Flocculation protein FLO11
- Mucin-5AC
- Nematode cuticle collagen N-terminal domain-containing protein
- Nematode cuticle collagen N-terminal domain-containing protein
- Protein lon-8
Sequence:
MSVTTATSGALIFSGASLLVSLFAAASIYSQVSSIWTELDNEIDSFKLLTNDIWGDMINLGAGSASNRIRRQAYGGYGATGTNAPEPQFPQGDKGPLPVPGLPFGPNVSGGSDRCQCTVENTCPTGPDGEEGEQGPDGQDGVDGVPGFDGQDCPDVEQQPSQGCFTCPQGLPGPQGSQGAPGIRGMRGARGQPGYPGRDGQPGMPGEMGPTGAPGDDGAPGASGMKGDDAEKPVGRQGQRGQPGEQGPDGEEGPAGKDAFEGPPGVEGEVGVPGYQGSAGPDGEEGPRGPSGLPGKDAEYCKCPTRDDGGNSHRAWRRKHKRVY
Protein: Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) (P46096)
Organism: Mus musculus (Mouse)
Function: Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:23345244}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}.
Interaction partners:
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 2
- Protein S100-A13
- Complexin-1
- Syntaxin-1A
- Stonin-2
- DnaJ homolog subfamily C member 5
- Ras-related protein Rab-3A
- Vesicular glutamate transporter 1
- Vesicle-associated membrane protein 3
Sequence:
MVSASRPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK
Protein: Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) (AC2) (P26769)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors.
Subcellular location: Membrane {ECO:0000269|PubMed:1719547, ECO:0000269|PubMed:22906005}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:1719547, ECO:0000269|PubMed:7761832}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q08462}.
Interaction partners:
- Guanine nucleotide-binding protein G
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Guanine nucleotide-binding protein G
- Protein kinase C beta type
- Rap guanine nucleotide exchange factor 4
- Protein kinase C gamma type
- Rap guanine nucleotide exchange factor 3
- Cannabinoid receptor 1
- Protein kinase C delta type
Sequence:
MRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGACLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSVYLSATPGAKEHLFWQILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASTSLMWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSVPDNQASILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNLAS
Protein: CD24 molecule (A0A087WW33)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLSSAAGREITLPEGSRRPPPTRSHWNSQPLSGPRGAFCSLSGNALAPGQAATPPQRRRGLFFWGIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS
Protein: Transcobalamin beta b (A2BFS9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transcobalamin II
- ferroxidase
- Aerolysin-like protein
Sequence:
MTLTAITLLCFAALLPFPGLGKGGHSGEQHGGVPGQVSINVVVTNKFANELNTYPVTAPKGMPIFGVLNQLQDSNQLNFTYSISKSYGIFLESVNGLAGSTENKTYWELLSKRERKTTRLNVGIGCYQPERNENFIMNFTTWA
Protein: GH14650p (Q9I7Q8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGKSFDDNMSFTDEHIHLPLHAQNTSTTMTTTITTQFQQQQSQSAVSSTSAAKETGGDLPNSSETDTTPVPPSKESESKTETEPTVVTNAFTTTSHDTPTPKPRVLKASSPVSEGTDSTTIPGPVPKPEIPIDISFDANAPVPKPRAPIKHTEPFENLAALAEQSDSISLRSFELTEDISKTDEPSTELSIRSQLRDIVTTTTVSEDHTESFEPTSEISVDDADTEKSEGAEKTTSFYIGESSRNVIIKTSTRSASVTPQEEEAQGEIGIDAKDISLMKEVSVDSDEANDVFKEFITMKPEDPIAMDSKITRQGSETRNDILEFENADKDKTAEQKLSKVTTEESLTTSTGSSGRAIIEIAPSSSEDPDESSKEIPEIVNTISEKAAASDNFELPLEKSEWETSEKEIPTEGKPKVVHSPQQPQEASMKSTLDRFHVDEILAEEQVTDEHSSSDHKSFKDQTPSELGSSTVPQEYTFAVESEDISSFIGIPEASMQTSTLDSTQPPEGLFDTTIKETLNKQAAMAHYAQDVFGRGERRDDHGSLGFISTGTAEELSSMEEHMAKEEQASLGFISTETAEDFSSMEDYYSEKLAIASVVADEVATEKSLTTSTFEELSSDQSMKPIDVVVHRLKTETSPDSINRWSIPDVDTSSSSESFHRSFDKTQSRPLSSDLDNLVTTTGTGTSSDYQTAREFTTTGRTEGTEYISAVSTLGSSSLDSQSETSANLASIDVSELSETLVASSAEVDAFEAEEMSRLRDLRADDEDSDESVELPGTAGYPSIEQQSLMKRSQEMIFKPKTLDDEPLAVQVAQIEEYPKPKEAERTWGLAYPLEDSKVDSPRESEKGEDILLYHGDPRRSIDESKLASSLDEGSILSVSMSSTSNIDTVVENFDDIIGSAGSSSLTGIEGFQYGHDESIPSASVPEDATFMLEMESKEHSPQDSNASTPPGGESKRRGHKRNESISGDALKNLDKEVALLGEGKESESESDTDPYESEYARQFRSPKERKSKKKKQAAAEMDHSGELEKRPFTPSQLVAEVIVEDSITEELEAEAAMIEERRPSQNMQDYSNIPDIMVTEDIKSPILEEETDEFPEKMLYKVRTEEELHKASDTSVYQKAKAEEKEQDFQRRVQEQYRQKLEELKRAEVGAEYDDRKAPDSPDSFEMVEQPDISDEFVIIEEVAKEANEVDLGGQSIKIKPVKYEQKHDEDVEKIIIKSAPADPKLGSQLYKDDLNFEFEESPPTGASSSSEQQEESDSSETAAANKRWVEMQLTDNQLRYPYDLAGAVLEDIKEEDGEFEVGSSRISSFKDSFSSTPEYDVAARRYHSRGEHDDVSMSSLQEFESLEQAISLENRNRTHQGSTDSSNGSFTRRYVVRHSGSGTAPGDDVSVSSLKDFEGLENACIEAHLIEIKAREEAALLSRSDESNKSNGSDKGATGNVVVTKVTRTVTRTEVVPSSQVESIEALLKQKLEREEGSVQGRVTDIGTTELDTKSKIDSQDSEKDSIDSMEISKSHDMMTSSIESFDISKDATTRSDVDSLEIDKRHSRQESIESFGDEQLDLMTKFVSGGGVTLGDGLTTTTTTTTTSTDADGHEHTVTRVITTITNVGGGIQELPMDESGMSKDVSVDSLNMCVEQTTSSAGTTATYQTSAGNSQMSGSVTSCASSTLMEDSFPGVGGMSSSQMSASFWSHDESTVVEDEGRDLAKKPQQGH
Protein: RH09188p (Q8MLQ7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- RE51539p
Sequence:
MSVERDDEYLKFVPHTMSYQVVPGSEFQCKKASYSSRKLSTIDEQDDDAANRRGMMHQILATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAWCANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAKERVTTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHIEDYFNGDNWLWFRRDRGYKTVNLQPLEPLKDTRGLEA
Protein: Leucine rich repeats and calponin homology domain containing 3 (H7C0J8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
YEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNLCSPSDILQLNLSV
Protein: Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9) (Q9NZI6)
Organism: Homo sapiens (Human)
Function: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1.
Subcellular location: Nucleus {ECO:0000269|PubMed:10644752}.
Interaction partners:
- Steroid hormone receptor ERR2
- Cholesterol side-chain cleavage enzyme, mitochondrial
Sequence:
MLFWHTQPEHYNQHNSGSYLRDVLALPIFKQEEPQLSPENEARLPPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVFHDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDVAYQVNSAPSPSYNGSPNSFGLGEGNASPTHPVEALPVGSDHLLPSASIQDAQQWLHRNRFSQFCRLFASFSGADLLKMSRDDLVQICGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNRVPLQQKRDGSGDSNLSVYHAIFLEELTTLELIEKIANLYSISPQHIHRVYRQGPTGIHVVVSNEMVQNFQDESCFVLSTIKAESNDGYHIILKCGL
Protein: NAD(+) hydrolase SARM1 (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (Sterile alpha and TIR motif-containing protein 1) (Q0D2N8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
FFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
Protein: Tripeptidyl-peptidase 2 homolog (TPP-2) (EC 3.4.14.10) (Multicorn protease) (Q9UT05)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Inner kinetochore subunit cnp3
Sequence:
MIPSDYSNKFYPVDGVVPKHETQAYEFLKKFPEYDGRGVTVGILDTGVDPGAPGLSVTTTGLPKFKNIVDCTGAGDVDTSVEVAAADSNDYLTITGRSGRTLKLSKEWKNPSKKWKVGCKLAYEFFPKDLRKRLQKLETEDMNKSNRKLLQDATDEYAKFKDKFPEAPLDKDNLQTQKELEARIECLKQLAEKFDNPGPLYDVVVFHDGEHWRVVIDSDQTGDIYLHKPLADFNVAQEWSTFGSLDLLSYGVHVYDNGNITSIVAVSGTHGTHVAGIIGANHPETPELNGAAPGCQLVSLMIGDGRLDSLETSHAFSRACSEIIKNEVDIINISFGEDAGIPNKGRVIELLRDELAGKRNVVIVSSAGNNGPAYTTVGAPGGTTFDVISVGAYVTSGMMQAQYNLLSTVHDTPYTWCSRGPTLDGDTGVSIYAPGGAITSVPPYSLQNSQLMNGTSMSSPSACGGISLILSALKAQKKPYTAAAIKKAVMYTSKDLRDDFNTGMLQVDNAYEYLAQSDFQYTGARSFTINGNIGNSKRGVYLRNPTEVCSPSRHMFNVAPKFEDGEEYEKSHFEVQLSLATTQPWIQAPEYVMMAGTGRGIPVRVDPTALAPGHHFGKVLAYDASNESRRCVFEIPVTVMKPSSISNTCFSLRDVSFEPTLIKRHFLVPPKGATYVEIRVKATSELESTNMLWISVNQTIPQTKLNEASTELIMPVTQNEVTTKLVSIDDSYTLELCMAQWWSSLEPMVLDIDVNFHGIKVVNGKEINLISSQGLKRVDCASIRRENFKPDITLKDYVDSFKPTNTVIKPLGDRDIMPDGQQLFELMATYSVEISEKTELKADFAVPHNMYDNGFNGLFFMVFDSQKQRVHYGDMYTSSHTLEKGEYLYKFQLLSVDPSTLERFRNVTLRLTKKLKKPITLPLYADHIDFCDNKTYERENIDAGVVESFVVGTNIEGEQYASELKENSLLTGELKFGDCEKGTVPVTLVLPPKISTKEDTKLGEKCANIVQLQVDLLSKLADQEKEKHLKYLQSSYKNSLEVQLAKLDIVKETNERLSTADSILSLIDTEALSRYYSCQQKVEDTIPRDVVLEKKMALQRDAFIRALVVKCETFSTQGHKDKDNYFQNYQLLLNWLENSDPRVWQIKKDYYKSQNQYGLALKALLELLKENGNSGKMDVAKLLSEEKELLVNLGWNYWHDIVFVETVKRVPPYSYALF
Protein: Phosphotransferase (EC 2.7.1.-) (Q9GTU5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLDAEVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRFTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVASKTK
Protein: G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 (EC 2.7.11.1) (S-domain-1 (SD1) receptor kinase 1) (SD1-1) (O81833)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MREIHSLFSLSLFLISSSLSVALDYNVITPKEFLKDGDTLSSPDQVFQLGFFSLDQEEQPQHRFLGLWYMEPFAVVWVANRNNPLYGTSGFLNLSSLGDLQLFDGEHKALWSSSSSSTKASKTANNPLLKISCSGNLISSDGEEAVLWQSFDYPMNTILAGMKLGKNFKTQMEWSLSSWKTLKDPSPGDFTLSLDTRGLPQLILRKNGDSSYSYRLGSWNGLSFTGAPAMGRENSLFDYKFTSSAQEVNYSWTPRHRIVSRLVLNNTGKLHRFIQSKQNQWILANTAPEDECDYYSICGAYAVCGINSKNTPSCSCLQGFKPKSGRKWNISRGAYGCVHEIPTNCEKKDAFVKFPGLKLPDTSWSWYDAKNEMTLEDCKIKCSSNCSCTAYANTDIREGGKGCLLWFGDLVDMREYSSFGQDVYIRMGFAKIEFKGREVVGMVVGSVVAIAVVLVVVFACFRKKIMKRYRGENFRKGIEEEDLDLPIFDRKTISIATDDFSYVNFLGRGGFGPVYKGKLEDGQEIAVKRLSANSGQGVEEFKNEVKLIAKLQHRNLVRLLGCCIQGEECMLIYEYMPNKSLDFFIFDERRSTELDWKKRMNIINGVARGILYLHQDSRLRIIHRDLKAGNVLLDNDMNPKISDFGLAKSFGGDQSESSTNRVVGTYGYMPPEYAIDGHFSVKSDVFSFGVLVLEIITGKTNRGFRHADHDLNLLGHVWKMWVEDREIEVPEEEWLEETSVIPEVLRCIHVALLCVQQKPEDRPTMASVVLMFGSDSSLPHPTQPGFFTNRNVPDISSSLSLRSQNEVSITMLQGR