wanglab/gogpt-training-data huggingface dataset:
Protein: Protein cutoff (Q9V629)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the piRNA pathway in germline. tissues.
Subcellular location: Cytoplasm. Nucleus {ECO:0000269|PubMed:24906153, ECO:0000269|PubMed:25085419, ECO:0000269|PubMed:27292797}. Chromosome {ECO:0000269|PubMed:24906153, ECO:0000269|PubMed:25085419}. Note=Localized to perinuclear puncta in the nurse cells of younger egg chambers. Accumulates at centromeric/pericentromeric positions in germ-cell nuclei and strongly colocalizes with the major heterochromatic domains. Localizes to nuclear foci corresponding to dual-strand, but not single-strand, piRNA clusters (PubMed:24906153, PubMed:25085419). All components of the Rhino-Deadlock-Cutoff (RDC) Complex associate with these nuclear foci and are required for their formation (PubMed:24906153). {ECO:0000269|PubMed:24906153, ECO:0000269|PubMed:25085419}.
Interaction partners:
- 5'-3' exoribonuclease 2 homolog
- Ribosomal RNA-processing protein 42
- Twitchy
- Uncharacterized protein, isoform A
- Chromo domain-containing protein rhino
Sequence:
MNSNYTILNIRAHSWAEKDNLVFPTITKPVSNGWFAWSPIGQFEPNSQKVPYVVVPPSIKFPISLRYKDSPPKLEKKPNIFLDNMLQYIESSSYMYVMVRNNQQAQLNANIVCTSEVLELMMCAPYEKKTGWSLGVTRYRNTMYICRIDVEQPDPIDQDNLKRAMQEFWLRNLRTHCVFENGIKMHQHNQSSEEHLRFHGVFSFDLNGNRVLFDSPVLAEMPSTTLNGSALSWVDLQIRPMFMSRLDWPEHNRTEALKWWVKCFLLGIESLYIARRDENAHVHNIEKTLVRDLWKSCEKDWSPTVCANFMIYLLNCISQVMAPIDCPSTVYLFQFDASQGTVSYKGLRGRNQYTFVSDWFRMMLDDHTNDMCKTPNLQTMSSIV
Protein: Polyketide cyclase/dehydrase and lipid transport superfamily protein (Putative membrane related protein) (Q9XIR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- CDPK-related kinase 4
- AT2G24420 protein
- At1g52870/F14G24_14 family protein)
- Probable cysteine protease RDL5
- START
- Pleckstrin homology
- Protein ENHANCED DISEASE RESISTANCE 2-like
- ENHANCED DISEASE RESISTANCE protein
- FCS-Like Zinc finger 14
Sequence:
MMGLSSLVFTEFHSLGFSDLIVFVAPLWIAVAAGVLVGWVWRPKWAYLDSKLLSNSPKFLNLQLPTSILKTSSHHVNPSLSSKEKTGFVTDDDFRHLWKLVEVKDGGPCWIQMMDRSTPTFSYQAWRRDPENGPPQYRSRTVFEDATPEMVRDFFWDDEFRSKWDDMLLYSSTLERCKDTGTMVVQWVRKFPFFCSDREYIIGRRIWDAGRVFYCITKGVQYPSVPRQNKPRRVDLYYSSWCIRAVESKRGDGEMTSCEVLLFHHEDMGIPWEIAKLGVRQGMWGAVKKIEPGLRAYQRAKAAGAGLSPSAIMAHINTKVSAEEFMNERGSIAEVTGDKPTGKNIPKILVVGGAIALACTLDKGLLTKAVIFGVARRFARMGKRM
Protein: Metal tolerance protein A1 (AtMTP2) (AtMTPa1) (Q9M271)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in sequestration of excess zinc in the cytoplasm into vacuoles to maintain zinc homeostasis.
Subcellular location: Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Tonoplast.
Interaction partners:
- Metal tolerance protein C4
- Metal tolerance protein 10
- Metal tolerance protein 9
- Metal tolerance protein C1
- Metal tolerance protein 11
- Putative metal tolerance protein C3
- Cadmium/zinc-transporting ATPase HMA2
- Glycosyl hydrolase family protein with chitinase insertion domain-containing protein
- Late embryogenesis abundant protein 37
Sequence:
MDSRRSKVCGETACGFSTSSSDAKKRAASMRKLCFVVVLCLLFMSIEVVCGIKANSLAILADAAHLLTDVGAFAISMLSLWASSWEANPRQSYGFFRIEILGTLVSIQLIWLLTGILVYEAVTRLVQETNDDVDGFFMVLVAAFGLVVNIIMIVVLGHDHGHGHDHGHSHDHGHSYGERAEQLLEKSKEIRNINVQGAYLHVLGDLIQSIGVMIGGGMIWYNPKWKVIDLICTLFFSVIVLGTTIKMLRSILEVLMESTPREIDARQLEKGLMEIEEVVDVHELHIWAITVGKALFSCHVKVRPEAGDEMVLNKVIDYIWREYRISHVTIQIER
Protein: Carboxypeptidase 1 (EC 3.4.17.19) (BsuCP) (P50848)
Organism: Bacillus subtilis (strain 168)
Function: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. Has lower activity with substrates ending with His or Trp.
Interaction partners:
Sequence:
MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRAESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAEYKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDLFEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNIDEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDDFVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYLGITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEFHPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL
Protein: Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase) (A6H8T5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
METLRNTSYPTITTHSEKMCELSKISEQGWKKSEENSRTEYSRIITDPNTGKCYCRGKVLGKGGFAKCYEMTDLSSSKIYAAKIIPHTRVSKPHQREKINREIELHRTLSHKHIVHFYHHFEDKDNIYILLEYCGRRSLAHILKARKVLTEPEVRYYLKQTVSALKYLHDLEILHRDLKLGNLFVSDSMELKVGDFGLAAKLEPVSNRRKTICGTPNYLSPEVLNKQGHGWESDVWALGCIMYTMLLGKPPFETTNLKETYRCIREARYTLPSSLSLPAKQLISGMLAQNPVDRPHLDDIIRHEFFTQGFMPETLPVSCCLSAPDFHISSPAKSFFKKAAAALFGGKKDKAKYYENINRLAKEEEDIFKLRQDFRKTAISNQITTHSPEEGGNPSAPTRKPVTQATAGRPQTTRDTIHLIVRGSLGSSSSSSECLEDSTTGTVAEAVISVLRGCLEHMPKADSLPRGNGCNSLKWVTKWVDYSNKYGFGYQLSDNTVGVLFNSGTHMSLLSDKKTVHQHAALGQKSVFSVIEAPECAVAHVTILKYFAHYMEENLMDGGDVISEPDIQKTRIYLLQWLKSDRALLMLFNDGTFQVNFYHDHTKLILCTQQDEYLLTYINEERTSATFQLSTLLSAGCTADLRSRLEYALNMLLQRCN
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8Y4P3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XDPIEEALGLPSSLDSLDQMNQDGGGGDVGNSSASELVPPPEETAPTELSKESTAPAPESITLHDYTTQPASQEQPAQPVLQTSTPTSGLLQVSKSQEILSQGNPFMGVSATAVSSSSAGGQPPQSAPKIVILKAPPSSSVTGAHVAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSGNTVLAAKVPGNQAAVQRIVQPSRPVKQLVLQPVKGSAPAGNPGATGPPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQGHRHVVLGSLPGKIVLQGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQKIQIVPQPPSSQPQPQQPPSTQPVTLSSVQQAQIMGPGQSPGQRLSVPVKVVLQPQAGSSQGASSGLSVVKVLSASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSPREDEESSIQKRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRIVKKELPSGQYTEAEEFFVKYKNYSYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDKDNGEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLINGEGMLGIYLNFCSTCVYFPDDSPWGQWMH
Protein: Rho GTPase activating protein 33 (A0A8I6A7N0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLQAQKQSDPILPWGASWAGRGQTLRARSTDSLDGPGESSVQPVPPTGGPGTKGKPGKRLSAPRGPFPRLADCAHFHYENVDFGHSLAPPHTAPQPG
Protein: Nuclear intron maturase 2, mitochondrial (AtnMat2) (EC 3.1.-.-) (Nuclear intron maturase 1 b) (AtnMat1b) (Q9FJR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Involved in the splicing of mitochondrial COX2, NAD1 and NAD7 transcripts. Necessary for mitochondrial biogenesis during early developmental stages.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19946041}.
Interaction partners:
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- Nuclear intron maturase 4, mitochondrial
- RCC1 domain-containing protein RUG3, mitochondrial
- Pentatricopeptide repeat-containing protein At1g74900, mitochondrial
- Transcription termination factor MTERF15, mitochondrial
- Maturase
- Pentatricopeptide repeat-containing protein At3g48250
- Protein WHAT'S THIS FACTOR 9
- Transmembrane 9 superfamily member 5
- Pentatricopeptide repeat-containing protein At1g51965
Sequence:
MRRSFSVLGPYKWLKPSSTYTNVYCFVTNPPLISNPNNGSAIFRYLSYFAPQQRRQQQQAPDPDDPANLLKEDGVSLCSQMWLENFKEPDKTATNLTSYLRRFELWVLAYQKVCCDELGAYVPRSSIQRSALENLLALRNSVLDDRFKWGSRLDFYIKSPRDKTDYESLSKRKIKAILTTTQPTPFQDRIVQEVLLMILEPIYESRFSQKSFAFRPGRTAHTVLRVIRRNFAGYLWYVKGDLSVVLDGMKVGFVISSLMRDVRDKKVIDLIKSALVTPVVTSKVEDGEKKKTKKRKYQKKRVLAEDEPKPDPYWLETFFGFAPEEAGKSPQWGHCGILSPLLVNVCLDELDRWMETKVKDFYRPSKSDVIWNNPEGEADQGNTSWPEFVPTSGPDKTRKMDYVRYGGHILIGVRGPRADAATLRKELIEFVDQKYMLRLDNENLPIEHITKGIMFLDHVLCRRVVYPTLRYTATGGKIISEKGVGTLLSVTASLKQCIKQFRKLLFIKGDRDPDPQPCFRMFHATQAHTNNQMNKFLTTIAEWYRFADNRKKIVNFCSYIIRGSLAKLYAAKYKLRSRAKVYKFANRNLSLPLLQKKGQSPEYQNLLRMGLAESVDGLVYTRMSLVPETDYSPFPGNWRPEHEKFLIEYLTLDEPKTLEEQKRFIREKGLVSPQDYTSMLVWNYKRNAIPMDQVSILKDQPFLLGSSSTYNRDNDDQKNKEEDEDSEDGLRIARM
Protein: tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) (Q9BU70)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability (By similarity).
Interaction partners:
- Hemogen
- Forkhead box protein E1
Sequence:
MRGLEESGPRPTATPCGCVKPALETGNLLTEPVGYLESCFSAKNGTPRQPSICSYSRACLRIRKRIFNNPEHSLMGLEQFSHVWILFVFHKNGHLSCKAKVQPPRLNGAKTGVFSTRSPHRPNAIGLTLAKLEKVEGGAIYLSGIDMIHGTPVLDIKPYIAEYDSPQNVMEPLADFNLQNNQHTPNTVSQSDSKTDSCDQRQLSGCDEPQPHHSTKRKPKCPEDRTSEENYLTHSDTARIQQAFPMHREIAVDFGLESRRDQSSSVAEEQIGPYCPEKSFSEKGTDKKLERVEGAAVLQGSRAETQPMAPHCPAGRADGAPRSVVPAWVTEAPVATLEVRFTPHAEMDLGQLSSQDVGQASFKYFQSAEEAKRAIEAVLSADPRSVYRRKLCQDRLFYFTVDIAHVTCWFGDGFAEVLRIKPASEPVHMTGPVGSLVSLGS
Protein: Inosine-adenosine-guanosine-nucleoside hydrolase (EC 3.2.2.1) (Q57ZL6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleoside hydrolase, putative
- Guanine deaminase
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Adenosine kinase
- Adenosine kinase
- Hypoxanthine phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
- NAD-dependent protein deacylase SIR2rp3
- NAD-dependent protein deacetylase SIR2rp1
Sequence:
MAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGEGKPCVHVARNPSKQMFHDLVFASTRVC
Protein: procollagen-lysine 5-dioxygenase (EC 1.14.11.4) (A4U7F8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004367}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004367}; Lumenal side {ECO:0000256|ARBA:ARBA00004367}. Rough endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004427}.
Interaction partners:
Sequence:
MERRRGFHAFVLMLVTCVHCTLGMETNKDIPTEKLLVLTVATQETDGFLRFMQSANYFNFNVKVLGMGEEWKGGDVGHSIGGGQKVRLLKEAMESLDQQEDLVVLFVDSYDLIFAGGAEEILRKFQQSNHKVVFAAEGIIWPDSQLAEKYPSVRSGKRFLNSGGIIGYAPYIQKLVSQWDLHDNDDDQLFYTKIYVDPIQREKLNMTLDHKCEIFQNLNGALDEVLLKFGTERVRVRNTIYNSLPAVIHGNVNTKVYFNYLANYIPNAWNYERGCTICDQDMVDLSQLKEFPQVTVGVYIEQPTPFLPEFLERLLSLDYPKDKLNIFIHNSEVYHEKHIQKFWEENKDVFGSFKAVGPEENLTQGEARNMGMDVCRRDPSCDYFFNIDADVMLTNRQTLKLLIEQNRKIIAPLVTRHGKLWSNFWGALSLDGYYARSEDYIDIVQGKRVGVWNIPFLAHVYLIKGQTLRNELKERNVFVLEKLDPDMAMCRNARDLGLFMYLTNRHEFGRLISTANYNTSHYNNDLWQIFENPLDWREKYIHANYTRIFTENLLEQPCPDVFWFPVLSEKACNELVEEMENHGTWSGGKHEDKRITGGYESVPTDDIHMKQINYDQEWLHFIREFISPVTLKVFSGYYTKGYAIMNFVVKYTPDRQAYLRPHHDSSTFTINIALNNKGLDFLGGGCRFHRYNCSIESPRKGWSFMHPGRLTHLHEGLPVTNGTRYIAVSFVDP
Protein: Atos homolog protein B (Q7L5A3)
Organism: Homo sapiens (Human)
Function: Transcription regulator that may syncronize transcriptional and translational programs.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q7JXG9}.
Interaction partners:
Sequence:
MRHVQAEPSPSSEPEAGPSQPPVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGTSEPHRALKRQAPSTEGPRELKRGPGLGAREGLPPEEPSTVGLLGPEGPGLGLGVASQHFSHRGLCVVEQRSSVTSSWTSGAWSPPCPPSNASCNTLHTRDWASPDPGGQGSLGESPGPAPPGQLHTLDTDLHSLAQIGGKSPVAGVGNGGSLWPRESPGTANGHSPEHTPPGPGPPGPCPTKRRLLPAGEAPDVSSEEEGPAPRRRRGSLGHPTAANSSDAKATPFWSHLLPGPKEPVLDPTDCGPMGRRLKGARRLKLSPLRSLRKGPGLLSPPSASPVPTPAVSRTLLGNFEESLLRGRFAPSGHIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGIVDLNPLGRKGYSVPKVGTVQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNANPTHRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP
Protein: Non-specific lipid transfer protein GPI-anchored 13 (AtLTPG-13) (Protein LTP-GPI-ANCHORED 13) (Protein YELLOW-LEAF-SPECIFIC GENE 3) (Xylogen-like protein 9) (AtXYLP9) (AtXYP9) (O64864)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable lipid transfer protein.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- At5g06430
- Beta-glucosidase 16
- At1g10140
- Cytochrome P450 76C2
- Copper ion binding protein
- Amino acid transporter AVT6D
- UDP-glycosyltransferase 76C5
- Phosphoglycerate mutase family protein
- Glycine-rich protein 3 short isoform
- Insecticidal crystal toxin domain-containing protein
Sequence:
MESRKIKVMATAIALIMVAMVVDAAGADKGKDKEECTAQLVGMATCLPYVQGKAKSPTPDCCSGLKQVINSDMKCLCMIIQERNDPDLGLQVNVSLALALPSVCHATADITKCPALLHLDPNSPDAQVFYQLAKGLNETVSASAPTGSASEPTSMSSTPGSSAGNNSGRTTSVPGTNHAQSFSKQWLGLEVVAHFFVIFYIFILV
Protein: Zinc finger protein 36 (Protein BROAD-SPECTRUM RESISTANCE DIGU 1) (Q75KE5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor involved in abscisic acid (ABA) signaling. Required for the regulation of the cross-talk between NADPH oxidase, hydrogen peroxide and MAP kinase in ABA signaling. Regulates the expression of the NADPH oxidase genes RBOHB and RBOHE, and the MAPK genes MPK1, MPK4, MPK5, MPK7 and MPK14. Regulates ABA-induced hydrogen peroxide production and antioxidant defense. Required for tolerance to water stress and oxidative stress.
Interaction partners:
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- protein-serine/threonine phosphatase
- Os04g0589400 protein
- Small ribosomal subunit protein uS2c
- Os01g0220300 protein
- Os06g0255200 protein
- Os02g0102400 protein
- Small ribosomal subunit protein mS29
Sequence:
MTAALQALLDPTALSLGLPTPAINKEEYLAICLAALACTRAGKALVGVGGQQQVQACNKWLCPAPAAPEELRFRCTVCGKAFASYQALGGHKSSHRKPPSPGDHYGAAAAAQQLASAGDSKEDSASSAAGSTGPHRCTICRRSFATGQALGGHKRCHYWDGTSVSVSVSASASAASSAVRNFDLNLMPLPESTAAAGIKRWAEEEEVQSPLPVKKLRMSN
Protein: CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) (Q3LRZ1)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q53ET0}. Nucleus {ECO:0000250|UniProtKB:Q53ET0}. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus. {ECO:0000250|UniProtKB:Q53ET0}.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 1
- Histone lysine acetyltransferase CREBBP
- Serine/threonine-protein kinase SIK1
- CREB regulated transcription coactivator 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- RAC-alpha serine/threonine-protein kinase
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Cyclic AMP-responsive element-binding protein 3-like protein 3
- RAC-beta serine/threonine-protein kinase
Sequence:
MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLFRLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGFLDGEMDAKVPAIEENLVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMSTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSLSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPSHPPTPKSLQQLPSQACLVQPSGGQPPGRQPHYGTLYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESPSTSLVLDPPAFSEGPGFLGSEGSVSGPQDSHVLNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRLQ
Protein: Conserved protein (O06578)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable pyruvate, phosphate dikinase PpdK
Sequence:
MSELTVLQAVRLKGRVITTDLAQTLGEDLADVAATVDRLTAAGLLVDATPLRISPSGRMRLDDLLAEERNRADSTVLAAAYRDFRSVNADFKRLVTDWQLKGEKPNTHDDAEYDAAVLSRLDGVHRRVGPIIGTVAMQLPRLSRYPVKLRAALDKVKAGDIAWLTRPLIDSYHTVWFELHEELIQAVGLTRDEAAKSGDAQ
Protein: Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) (Q15427)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular location: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}.
Interaction partners:
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Splicing factor 3B subunit 3
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 2
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Pre-mRNA-processing factor 6
- U2 small nuclear ribonucleoprotein B''
- U4/U6.U5 tri-snRNP-associated protein 1
- Microfibrillar-associated protein 1
- Splicing factor 3B subunit 5
Sequence:
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ
Protein: Thioredoxin M-type, chloroplastic (Trx-M) [Cleaved into: Thioredoxin M-type Mc; Thioredoxin M-type Md] (P07591)
Organism: Spinacia oleracea (Spinach)
Function: Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. The M form is known to activate NADP-malate dehydrogenase.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MAIENCLQLSTSASVGTVAVKSHVHHLQPSSKVNVPTFRGLKRSFPALSSSVSSSSPRQFRYSSVVCKASEAVKEVQDVNDSSWKEFVLESEVPVMVDFWAPWCGPCKLIAPVIDELAKEYSGKIAVYKLNTDEAPGIATQYNIRSIPTVLFFKNGERKESIIGAVPKSTLTDSIEKYLSP
Protein: AT4G30480 protein (Tetratricopeptide repeat (TPR)-like superfamily protein) (Q9M0B2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetratricopeptide repeat
- Transducin family protein / WD-40 repeat family protein
- Telomere repeat-binding protein 1
- Topless-related protein 3
- Auxin-responsive protein SAUR76
- Auxin-responsive protein SAUR78
- Protein NPG1
Sequence:
MVLIESSESEDEILIKNEPKPASSSSPQPTETKQVDGDDSDGFETASEREISDEEGEEDGTKNDAVTSQEEPQHSEKKEEQIELMSEGEAIVDDGSNKEKALAEANEAKAEGNKLFVNGLYEEALSKYAFALELVQELPESIELRSICYLNRGVCFLKLGKCEETIKECTKALELNPTYNKALVRRAEAHEKLEHFEDAVTDLKKILELDPSNDQARKGIRRLEPLAAEKREKMKEEAITKLKEMGNSILGRFGMSVDNFKAVKDPNTGSYSLSFQN
Protein: Facilitated trehalose transporter Tret1 (AmTRET1) (A9ZSY2)
Organism: Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Function: Moderate-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20035867}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:20035867}.
Interaction partners:
Sequence:
MGVENTKQTMSSQNIKPAKDSDDVLHTQFKEVKRSPMRYTMQLLAALAVSMASLMIGYSSSYTSPALVSMRDNTTATFEVTMDMAMWIGSIMPLSALIGGIIGGPCIEYIGRRNTILSTALPFLAGWLFIALATNVAMILVGRSICGFCVGVASLSLPVYLGESIQPEVRGSLGLLPTVFGNSGILMCFTAGMYLAWRNLALLGACIPIIFLILMFLIPETPRWYISKGKIKEARKSLQWLRGKTADISEELDSIQKMHIESERIATEGALIELFRKNHIKPVFISLGLMFFQQFSGINAVIFYTVQIFKDSGSTVDENLSTIIVGLVNFISTFVAAMIIDRLGRKMLLYISSILMCITLFTFGTFFYVKELMDVTAFGWIPLMSLIVYVIGFSFGFGPIPWLMMGEILPVKIRGTAASVATAFNWSCTFVVTKTYEDLVLHIGPYGTFWLFGTLVAVAFIFVIICVPETRGRSLEEIERRFAGPVRRTSAIANLKPMPITI
Protein: Melittin-related peptide FQ-22-1 (P86158)
Organism: Rana arvalis (Moor frog)
Subcellular location: Secreted {ECO:0000269|PubMed:19308951, ECO:0000269|PubMed:35820801}.
Interaction partners:
Sequence:
FVGAALKVLANVLPPVISWIKQ
Protein: Paralemmin A kinase anchor protein (F7AA26)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}.
Interaction partners:
- A-kinase anchor protein 1, mitochondrial
Sequence:
XFAQPLWKCLHRCGPFPLPLLAFRFLEPTPTHSDSLSLSLSLSLSLSLSLSLSLSPLSLHFFKEKRKRQTEIEGKRRQLDEQVLLLQHSKSKVLREKWLLQGVPAGTAEEEEARRRQSEEDEFKVKQLEDNIQRLEQEIQALESEESQISAKEQIILEKLKETEKSFKDLQKSFSTADGASGWSTVLLQGDELTADPIGTNADMAIQKPPQLSEDANQLRSKQDNCGDSRLEPAASSLSPDHKNMEIGVSVAECKSVPGVTSTPHSKDHSSPFYSPSHNGLLADHHESLDNDVAREIQYLDEVLEANCCDSSVDGTYNGISSPEPGAAILVSSLGSPAHSVTEAEPTEKASGRQVPPHIELSRSPSDRMAEGERANGHSTDQPQDLLGNSLQAPASPSSSTSSHCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEEDEREKEQFCVRKVRPSEEMIELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHRKYKERKEKRAQQEQLQLQQQQQQQLQQQQLQQQQLQQQQLQQQLQQQQLSTSQPCTAPAAHKHLDGIEHTKEDVVTEQIDFSAARKQFQLMENSRQTLAKGQSTPRLFSIKPYYKPLGSIHSDKPPTILRPATVGGTLEDGGTQAAKEQKAPCVSESQSAGAGPANAATQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDEDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETPSALQENSLADFSLPQTPQTDNPSEGREGVSKSFSDHGFYSPSSTLGDSPSVDDPLEYQAGLLVQNAIQQAIAEQVDKAEAHTSKEGSEQQEPEATVEEAGSQTPGSEKPQGMFAPPQVSSPVQEKRDILPKNLPAEDRALREKGPSQPPTAAQPSGPVNMEETRPEGGYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVRQSTPSPRAKNAPSLPSRTTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSALALRWEAGIYANQEEEDNE
Protein: Myb family transcription factor PHL11 (Protein PHR1-LIKE 11) (C0SVS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Anaphase-promoting complex subunit 6
- Uncharacterized protein
- Anaphase-promoting complex subunit 4
- Mitotic spindle checkpoint protein MAD1
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 5
Sequence:
MERVNLGGLGYDNGGVMMTRDPKPRLRWTADLHDRFVDAVAKLGGADKATPKSVLKLMGLKGLTLYHLKSHLQKYRLGQQQGKKQNRTEQNKENAGSSYVHFDNCSQGGISNDSRFDNHQRQSGNVPFAEAMRHQVDAQQRFQEQLEVQKKLQMRMEAQGKYLLTLLEKAQKSLPCGNAGETDKGQFSDFNLALSGLVGSDRKNEKAGLVTDISHLNGGDSSQEFRLCGEQEKIETGDACVKPESGFVHFDLNSKSGYDLLNCGKYGIEVKPNVIGDRLQ