wanglab/gogpt-training-data huggingface dataset:
Protein: Growth hormone receptor 2 (B5KME6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
AEEKAKEGKEKAKPRKEFQLLVVNADGGGYTTELDAGKMSAKLPTGRGSQPAPTEDSRLVQGQPFGEYQSLYFEAEMPPIPPASPVSSLLPLSVYTMVEGVDRQNSLLLKPSPPPAPQPVLTKLPLPTPTPEGYLTPDLLGNVTP
Protein: 2,4,5-trihydroxytoluene oxygenase (Q9KJH7)
Organism: Burkholderia cepacia (Pseudomonas cepacia)
Interaction partners:
Sequence:
MAITDIAYLVNDHTDLEAAERFYTDFGLKVAYRTADEIGFRPALARGYCYVARKSSKPGLRAIAFTASTRADLDVAARFPEASPITPIEREGGGDKVMLQSPDGLPFEIVHGIHSYEELAVRPALTFNTGRVKRRHGEFQRPPLEPAPILRLGHVALLTNDFKRNFEWMQSRLGLRPTDTMYGKDKNDLVGSFMHLSGGGEWTDHHSLALFPDPSPRVHHFSFEVEDLDAQGMGNQWLIKHGWKHTWGIGRHIYGSQIFDYWFDPDGNIVEHFTDGDLVRPGCKPGLVALDESLFAWGPPMQPANFVELAAHHE
Protein: Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Q95U20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
Sequence:
MLRIYQNTYRRTARKAVVYSTKVACCNHSTLCGITSHPRRAQDSGSSSSNGRHRGHEEFLLAGNPARGWQMPPPSRGYGMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPNFKWLEDAMPQGERWSQFSRNLIEVGSLVKNAIEVAKDDLKAKTTVAALGITSDESRKKYEKLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK
Protein: Esterase EstD (EC 3.1.1.1) (Q9WYH1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Exhibits significant esterase activity with a preference for short acyl chain esters (C4-C8) in vitro. Its physiological function is not known. Displays neither proteolytic activity using casein as substrate, nor peptidase activity when assayed with L-leucine p-nitroanilide and L-proline p-nitroanilide.
Interaction partners:
- UPF0313 protein TM_0337
- Orotidine 5'-phosphate decarboxylase
- Conserved hypothetical protein
- Dihydroorotate dehydrogenase B
- Hypothetical protein
- Putative dihydroorotase
- Orotate phosphoribosyltransferase
Sequence:
MRLTVFLSLFLGVMVFGAFDQEAFLFVQHLTSENFESALNMCSNQVKAQLSVQSLSNIWNSLKAQLSDFREIAGYEKIIQAEYEIYNFTLKFDRGEISALVTMDREGKVAGLFFKQATKTEYELPDYVDPESFEEKDITVNGLPGKITIPKGSGPFPAVVLVHGSGPNDMDETIGPNKIFKDIAYGLSSKGIIVLRYHKRTFVEKVDPTTLTVEKEVIEDALEAVKILKERKDVSRVYVLGHSLGAMLTPEIAERSKADGVVMIAPPARPLEEVMEDQLKYLQSLGLASNVEETLNILEKLKRKEIPPDEFVLGAPAKYFYDLRERDPASIAKRLTIPMLLIFGGRDYQVTEKDQEIWLKELSGRENVKILVFDDLNHLMISGEGKSTPVEYMKKGHVDKRVIDEIARWMVK
Protein: T. brucei spp.-specific protein (Q580Q2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKGPLSRAALRILREKESSAPSQDEEDMDYNQDSVFFSIPSPLRAHEAVRYTKPIRIAPQKSAKFNHTVAREFGDGRVPHLSRFAGDCKAKRERRADNEGEVHAAMTPRRHAFFVANKRDVPSPPRTTRELLNTPMGKQSPRQEFVGSSAATGHANLLAAAVAAVSSATGNNHITPRFTGDALILGSPRQTRAALLRREYTAKTTRDRALEAFAQPVDRFLESNKHPSIDTNLKADVITKSESIQTCQRESRGAVMVRPESVPTPIQPMRQSPASMTLAPTSSISRGSLLLTNVRSAIERNRECDDKKKVSLSAMRSPRAASPSAGVKSPARRRDNGIAWCAGGKLPSTEPHRLGSFCGNSQYRSSEQSFVMKKNMDHAAAGPPLTSRRQKANVPFGREISDWCPEDPEFAYEKCTLRWNAGCDIFGASSRGCSAPQPQVRAGQTYFGHASVEESGSSQFDVVEISDIIGTEEVTREDQANIDKKQMMEICENPLPSPPRERRPAASGDVRYDDHRKVLDSATQTDNTEGRMCQGLFLLSQPILNREKTNCGGDNDTSYLKPMSGKGVEMDPLVKAAELASNMSHFVENLHETIVGDVLGSVPSDAVTGDSMLTARSFKTCLEQEEDDSQAPFLRTQTLPMGPRNSPRTPSGGTSVDGKIPSERGSQLVEKNDDIFLEPLHSPQVWPSSTAQRWGKNVSIPLKRSVRCDEERLGTGGGHPTPTAFAALLNRVHLEFLRRYFRTWKEFVKRHTTQIAPSIRYVNAANSPIACKPLNNRCINRMMAAATCCKKQQLGAVQNATFKANGLTVDRLRLHARNSLQAAEKSNDFRYSKPLENTRSHRRMGPLDRDGNGSPGSHHRSLCSAETSFSCPSDSVRALVSMM
Protein: Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) (Q61313)
Organism: Mus musculus (Mouse)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Subcellular location: Nucleus {ECO:0000269|PubMed:25187989}. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. {ECO:0000269|PubMed:25187989}.
Interaction partners:
- YEATS domain-containing protein 4
- Transcription factor AP-2-alpha
- BTB/POZ domain-containing protein KCTD1
Sequence:
MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTNRHTSGEGPGSKTGDKEEKHRK
Protein: Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) (F4K191)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03140}. Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03140}. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. {ECO:0000256|HAMAP-Rule:MF_03140}.
Interaction partners:
Sequence:
MGIKGLTKLLADNAPSCMKEQKFESYFGRKIAVDASMSIYQFLIVVGRTGTEMLTNEAGEVTSHLQGMFNRTIRLLEAGIKPVYVFDGKPPELKRQELAKRYSKRADATADLTGAIEAGNKEDIEKYSKRTVKVTKQHNDDCKRLLRLMGVPVVEATSEAEAQCAALCKSGKVYGVASEDMDSLTFGAPKFLRHLMDPSSRKIPVMEFEVAKILEELQLTMDQFIDLCILSGCDYCDSIRGIGGQTALKLIRQHGSIETILENLNKERYQIPEEWPYNEARKLFKEPDVITDEEQLDIKWTSPDEEGIVQFLVNENGFNIDRVTKAIEKIKTAKNKSSQGRLESFFKPVANSSVPAKRKGNLICLVASEVIPNILDHRVPNACSGSINQPSAIKSPLCMLLDGTPPITLLALGCSLYPGLPTFRFTWLEEIPESTTKGAANKKTKGAGGRKKK
Protein: Lecithin-cholesterol acyltransferase-like 1 (EC 2.3.1.-) (Q9FZI8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212
- Mitochondrial thiamine diphosphate carrier 1
- ORMDL family protein
- At5g42000
- Thiamine pyrophosphokinase 1
- Diacylglycerol O-acyltransferase 2
- Bifunctional TENA-E protein
- GDSL esterase/lipase At5g55050
- Acyltransferase-like protein
- Purine-uracil permease NCS1
Sequence:
MKKISSHYSVVIAILVVVTMTSMCQAVGSNVYPLILVPGNGGNQLEVRLDREYKPSSVWCSSWLYPIHKKSGGWFRLWFDAAVLLSPFTRCFSDRMMLYYDPDLDDYQNAPGVQTRVPHFGSTKSLLYLDPRLRDATSYMEHLVKALEKKCGYVNDQTILGAPYDFRYGLAASGHPSRVASQFLQDLKQLVEKTSSENEGKPVILLSHSLGGLFVLHFLNRTTPSWRRKYIKHFVALAAPWGGTISQMKTFASGNTLGVPLVNPLLVRRHQRTSESNQWLLPSTKVFHDRTKPLVVTPQVNYTAYEMDRFFADIGFSQGVVPYKTRVLPLTEELMTPGVPVTCIYGRGVDTPEVLMYGKGGFDKQPEIKYGDGDGTVNLASLAALKVDSLNTVEIDGVSHTSILKDEIALKEIMKQISIINYELANVNAVNE
Protein: Leucine rich pentatricopeptide repeat containing (A0A0C4DG06)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFYFPI
Protein: H-2 class I histocompatibility antigen, alpha chain (Clone PH-2D-2) (P01896)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
WLHRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAMAIIGAVVAFVMKRRRNTGGKGGDYALAPGSQSSEMSLRDCKGDTLGSDWGGAMWT
Protein: Arginine ADP-riboxanase OspC1 (EC 4.3.99.-) (Q8VSJ7)
Organism: Shigella flexneri
Function: ADP-riboxanase effector that mediates arginine ADP-riboxanation of host caspases. ADP-riboxanation of host apoptotic caspases (CASP3, CASP8 and CASP9) prevents their activation, thereby inhibiting host cell extrinsic and intrinsic apoptosis. Does not catalyze ADP-riboxanation of host CASP4/CASP11. Independently of its ADP-riboxanase activity, acts as an inhibitor of calcium signaling by inhibiting host calmodulin, preventing activation of the JAK-STAT signaling pathway in response to interferon-beta. Mechanistically, acts by binding to the apo form of calmodulin, preventing calcium-binding and ability to activate host CaMK2 (CAMKII), which is required to stimulate the JAK-STAT signaling pathway in response to interferon-beta.
Subcellular location: Secreted {ECO:0000269|PubMed:16988276, ECO:0000269|PubMed:23684308}. Host nucleus {ECO:0000269|PubMed:16988276}. Note=Secreted via the type III secretion system (T3SS). {ECO:0000269|PubMed:16988276, ECO:0000269|PubMed:23684308}.
Interaction partners:
Sequence:
MNISETLNSANTQCNIDSMDNRLHTLFPKVTSVRNAAQQTMPDEKNLKDSANIIKSFFRKTIAAQSYSRMFSQGSNFKSLNIAIDAPSDAKASFKAIEHLDRLSKHYISEIREKLHPLSAEELNLLSLIINSDLIFRHQSNSDLSDKILNIKSFNKIQSEGICTKRNTYADDIKKIANHDFVFFGVEISNHQKKHPLNTKHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFLDKFSEVNKEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYGKNLAPVDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFLSITNQKEDVALYILSNFEITRQDVISIKHELYDIEYLLSAHNSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKYI
Protein: Small COPII coat GTPase SAR1 (EC 3.6.5.-) (GTP-binding protein SAR1) (Secretion-associated RAS-related protein 1) (P20606)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP by SEC12 binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Membrane association requires the presence of the SEC12 exchange factor.
Interaction partners:
- Protein transport protein SEC24
- Protein transport protein SEC31
- Guanine nucleotide-exchange factor SEC12
- Protein transport protein SEC23
- Protein transport protein SEC13
- Putative guanine nucleotide-exchange factor SED4
- COPII coat assembly protein SEC16
- SED5-binding protein 3
- GTPase-activating protein NEL1
- SED5-binding protein 2
Sequence:
MAGWDIFGWFRDVLASLGLWNKHGKLLFLGLDNAGKTTLLHMLKNDRLATLQPTWHPTSEELAIGNIKFTTFDLGGHIQARRLWKDYFPEVNGIVFLVDAADPERFDEARVELDALFNIAELKDVPFVILGNKIDAPNAVSEAELRSALGLLNTTGSQRIEGQRPVEVFMCSVVMRNGYLEAFQWLSQYI
Protein: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Brainiac 1) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase) (Q920V1)
Organism: Mus musculus (Mouse)
Function: Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O75752}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O75752}.
Interaction partners:
- Lactosylceramide 4-alpha-galactosyltransferase
- Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
- Alpha-1,3-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 4
- Alpha-N-acetylgalactosaminidase
- Beta-1,4-galactosyltransferase 3
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 2
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
Sequence:
MAPAVLTALPNRMSLRSLKWSLLLLSLLSFLVIWYLSLPHYNVIERVNWMYFYEYEPIYRQDFRFTLREHSNCSHQNPFLVILVTSRPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQQAEREDKTLALSLEDEHVLYGDIIRQDFLDTYNNLTLKTIMAFRWVMEFCPNAKYIMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFFHKNHISYQEYPFKVFPPYCSGLGYIMSGDLVPRVYEMMSHVKPIKFEDVYVGICLNLLKVDIHIPEDTNLFFLYRIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY
Protein: Uncharacterized protein (Q3TNM7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHPGLWLFLVSLCLTKELAESGQKMSYGKPCGSRDCHGVCTCFPEKGARGHPGPIGTQGPAGPEGFTGPTGLSGLKGERGSPGPLGPYGSKGDKGPIGVPGFVGISGIPGHPGQPGPRGPPGPDGCNGTQGAVGFPGPDGYPGILGPPGLPGHKGAKGEPVPFQGSITGIRGDPGLPGLDGIPGPSGSSGSPGDAGPIGPPGLQGPPGLPGLPGPEGNMGLGFQG
Protein: Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme) (Q9Y337)
Organism: Homo sapiens (Human)
Function: May be involved in desquamation.
Subcellular location: Secreted.
Interaction partners:
- Serine protease inhibitor Kazal-type 5
- Serine protease inhibitor Kazal-type 9
- Serine protease inhibitor Kazal-type 6
- Kallikrein-8
- Filaggrin
- Immunoglobulin kappa variable 1-33
- Chymotrypsin-like elastase family member 2A
- Suppressor of tumorigenicity 14 protein
- Desmoglein-1
- Kallikrein-7
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
Protein: Ubiquinol oxidase 1c, mitochondrial (EC 1.10.3.11) (Alternative oxidase 1c) (O22048)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:14671022}; Multi-pass membrane protein {ECO:0000305|PubMed:14671022}. Note=Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.
Interaction partners:
- External alternative NAD
- External alternative NAD
- Internal alternative NAD
- External alternative NAD
- External alternative NAD
- Internal alternative NAD
- Mitochondrial uncoupling protein 1
- Cytochrome c oxidase subunit 6b-1
- NADH dehydrogenase 1 beta subcomplex subunit 9
Sequence:
MITTLLRRSLLDASKQATSINGILFHQLAPAKYFRVPAVGGLRDFSKMTFEKKKTSEEEEGSGDGVKVNDQGNKGEQLIVSYWGVKPMKITKEDGTEWKWSCFRPWETYKADLTIDLKKHHVPSTLPDKIAYWMVKSLRWPTDLFFQRRYGCRAIMLETVAAVPGMVGGMLMHFKSLRRFEQSGGWIKALLEEAENERMHLMTFMEVAKPKWYERALVISVQGVFFNAYLIGYIISPKFAHRMVGYLEEEAIHSYTEFLKELDNGNIENVPAPAIAVDYWRLEADATLRDVVMVVRADEAHHRDVNHYASDIHYQGHELKEAPAPIGYH
Protein: Homeobox protein TGIF2LY (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, Y-linked) (TGIF-like on the Y) (Q8IUE0)
Organism: Homo sapiens (Human)
Function: May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Polyadenylate-binding protein 5
- Protocadherin-11 X-linked
- Homeobox protein TGIF2LX
- Transforming growth factor-beta-induced protein ig-h3
- Protocadherin 11 Y-linked
Sequence:
MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRARCQERSNQIRSRPLARSSPE
Protein: Photosystem I P700 chlorophyll a apoprotein A2 (EC 1.97.1.12) (PSI-B) (PsaB) (Q1G1M8)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_00482}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00482}.
Interaction partners:
Sequence:
MELRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFESWIQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGAAGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSTLSLIGGWLHLQPKWKPSLSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPASRGEYVRWNNFLDVLPYPQGLGPLLTGQWNLYAQNPDSSNHLFGTTQGAGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAFIFLIAGHMYRTNFGIGHSIKDLLEAHTPPGGRLGRGHKGLYDTINNSIHFQLGLALASLGVITSLVAQHMYSLPSYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTTYGFDILLSSTSGPAFNAGRTLWLPGWLNAVNENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWRDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
Protein: Small ribosomal subunit protein mS26 (28S ribosomal protein S26, mitochondrial) (H6UQ69)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAPGGCPLLALLLLAGTAQGQHWSHGWYPGGKRDLSAPQAIPAWSPWLVPSRGRKSRYDPPAKSKASRLKVPPPVDPAELYVVTERYRQHRLVLSALRSIFRSEVVQRKSEAQRDAEDSAALSEEHRLLMAWNDAENARQRARR
Protein: GEO11768p1 (RT03208p) (Seminal fluid protein 70A4) (Seminal fluid protein 70A4, isoform B) (B4ZJA3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO11741p1
Sequence:
MKLLNLLLVVLFLIGMVEARRRKREVEIWIRPEKHNPPGTRYCSPEDPMCQRYGD
Protein: Fatty acid elongase A (EC 2.3.1.199) (3-keto acyl-CoA synthase eloA) (Elongation of fatty acids protein A) (Very-long-chain 3-oxoacyl-CoA synthase A) (Q54CJ4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Fatty acid elongase with strict substrate specificity for monounsaturated fatty acids, in particular 16:1 (delta-9) to produce the unusual 18:1 (delta-11) fatty acid.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEHIHDINFQEFSKDPIGTIDRFRWKNEVTPFSNILFPIVCSFGYLALIYGLQIFMKNKKEIKLHGFAMFHNLFLCLLSLLMFLGIVIPMAKYSFPHGLYNIICKPIDSGLVQFSYYIFYLSKVYEFIDTIIQVLRKKSLLFLHVWHHFITLWLVWANLKYDTGCQWVDISANCFVHIVMYFYYFQTERGINPWWKKHITTCQIIQFIVDMSSHLAWHFYDTQGNHNSNYCSGTWATSAFSDFVILSFLGLFIQFFVKAYKKKSSIKKKTN
Protein: Partitioning protein REP2 (R2) (Protein Charlie) (Trans-acting factor C) (P03872)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of the plasmid partitioning system, which ensures the equal distribution of replicated plasmid molecules to daughter cells. The plasmids exist as well-organized plasmid foci within the nucleus that stay together throughout the cell-cycle and act as entity during segregation, effetively reducing copy number to one. Plasmid partitioning requires the proteins REP1, REP2, and a cis-acting locus STB (REP3). REP1-REP2 stably associate with CSE4-containing chromatin at STB during S-phase, marking the locus with a centromeric tag, and thereby probably catching mitotic spindle microtubules to the plasmid cluster and coupling plasmid segregation to chromosome segregation. REP1-REP2 are required to recruit the cohesin complex to the STB locus for pairing of the replicated plasmid cluster, a prerequisite for successful plasmid segregation. REP1-REP2 also negatively regulate expression of site-specific recombinase FLP and of RAF1.
Subcellular location: Nucleus {ECO:0000269|PubMed:10791970, ECO:0000269|PubMed:9393716, ECO:0000269|PubMed:9819432}. Note=Colocalizes with the STB locus of the 2-micron plasmid as foci in the nucleus near the spindle pole body. Is expelled from STB during a short interval between late G1 and early S phases.
Interaction partners:
Sequence:
MDDIETAKNLTVKARTAYSVWDVCRLFIEMIAPDVDIDIESKRKSDELLFPGYVIRPMESLTTGRPYGLDSSAEDSSVSSDSSAEVILPAAKMVKERFDSIGNGMLSSQEASQAAIDLMLQNNKLLDNRKQLYKSIAIIIGRLPEKDKKRATEMLMRKMDCTQLLVPPAPTEEDVMKLVSVVTQLLTLVPPDRQAALIGDLFIPESLKDIFNSFNELAAENRLQQKKSELEGRTEVNHANTNEEVPSRRTRSRDTNARGAYKLQNTITEGPKAVPTKKRRVATRVRGRKSRNTSRV
Protein: Protein RRP6-like 1 (AtRRP6L1) (Q0WVE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as an important epigenetic regulator through multiple silencing mechanisms. Involved in transcriptional gene silencing (TGS). Plays a role for DNA methylation in the RNA-directed DNA methylation (RdDM) pathway. Contributes to the methylation status of the retrotransposon SN1. Required for DNA methylation only at a subset of RdDM target loci. Plays a regulatory role in RdDM through retention of non-coding RNAs (ncRNAs) in normal cells. Helps to retain Pol V-transcribed RNAs in chromatin to enable their scaffold function and is required for genome-wide Pol IV-dependent siRNA (24 nt siRNA) production that may involve retention of Pol IV transcripts. Involved in association with RRP6L2 in the silencing of the solo LTR locus. Controls levels of ncRNAs from the solo LTR locus. Seems to function independently of the RdDM pathway. Functions redundantly with RRP6L2 in the regulation of FLC locus. Participates in the maintenance of trimethylated 'Lys-27' (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derived from the FLC locus. Seems not involved in the exosomal RNA degradation. Can complement the growth defect of a yeast mutant lacking RRP6 exonuclease.
Subcellular location: Nucleus {ECO:0000269|PubMed:18285452}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18285452}. Note=Also detected in the nucleolar vacuole. {ECO:0000269|PubMed:18285452}.
Interaction partners:
- Exosome complex component RRP4 homolog
- Exosome complex component RRP41 homolog
- Exosome complex exonuclease RRP46 homolog
- Exosome complex component RRP45B
- Ribosomal RNA-processing protein 43
- DExH-box ATP-dependent RNA helicase DExH9
- Exosome complex exonuclease RRP44 homolog A
- Exosome complex component RRP45A
- Nuclear nucleic acid-binding protein C1D
- Ribosomal RNA-processing protein 42
Sequence:
MRFDDPMDEFKRNRKMEEDSKKVIDVKVAESDKGFAKFGKAEVPFHIPTLTKPQEEYKILVDNANNPFEHVLLEKSEDGLRFIHPLEELSVMDFVDRNLSEMRPVKPLPLEETPFKLVEEVKDLEDLAAALQSVEEFAVDLEHNQYRTFQGLTCLMQISTRTEDYIVDIFKLWDHIGPYLRELFKDPKKKKVIHGADRDIIWLQRDFGIYVCNLFDTGQASRVLKLERNSLEFLLKHYCGVAANKEYQKADWRIRPLPDVMKRYAREDTHYLLYIYDVMRMELHTMAKEDEQSDSPLVEVYKRSYDVCMQLYEKELWTRDSYLHVYGVQTGNLNAVQLSIVAGLCEWRDRIARADDESTGYVLPNKTLFDIAKEMPIVVAQLRRLLKSKLPYLERNFDAVISVIRRSMQNAAAFEPVVQSLKDRRPETVVEMNIEPKIEKTDTGASASSLSLEKVCVDDSKKQSSGFGVLPLKRKLESDKTVVEKNIEPKIEKTGTEASASSLSSKKVCVDDSKKQSSGFGVLLSKRKFESDNKVKEEVKVSKSKPDKVIIVVDDDDDDDDDESYEQSTKAADALDRVSETPSKGSPSLTQKPKTCNTEVIVLDDDDDSESREDEDMRRRSEKHRRFMNMKRGFLNI