Protein: Piezo-type mechanosensitive ion channel component (M9MSG8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Plays a major role in nociception (response to strong or painful touch). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors. During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum. Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22343900}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein TIPIN homolog
- Ovarian-specific serine/threonine-protein kinase Lok
- No mechanoreceptor potential C, isoform H
- Amiloride-sensitive Na+ channel
- Chromosome transmission fidelity 4
- Serine/threonine-protein kinase ATR
- DNA replication licensing factor Mcm2
- Protein timeless
- Timeout
- CDC45L
Sequence:
MVFSYACMVLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLTLSTLVLLGHITLQILAVSLTLPIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVFATSLGSYLTVKRVASQPVGAEQLENGEVVDGQAENAQTSSQPSAADANGGDVQQATVTTPLQQQQQQLRKRVSMISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQRGFALLLRCVMVVLVLHSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFVSVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFIASLQQQPLAGGSAQQKPTETTALEPAPSKRRGSAGSLRKSQGPSAEAAPGATTDFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMFEEMDDKFELDLIHDEIDFLEEENITESEMKMQRRKTLYDKSKDAPTGEFPSTSKGISKERDAATASSSASPAPTRDVGDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDFDTNPIIRLLEGFLVTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSSTPRRVVIAPPNATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGDTDSIPSRMSVRRPEQLQPQQPQ