wanglab/gogpt-training-data huggingface dataset:
Protein: Protein drumstick (Q9VQS6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative transcription factor. May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation. Acts in a hierarchy during foregut and hindgut patterning and morphogenesis, antagonizing lin to relieve the repressive effect on bowl. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein lines
Sequence:
MFAVMRIDNDDCRSDFRRKMRPKCEFICKYCQRRFTKPYNLMIHERTHKSPEITYSCEVCGKYFKQRDNLRQHRCSQCVWR
Protein: Probable 26S proteasome subunit rpt4 (O74445)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Interaction partners:
- 26S proteasome regulatory subunit rpn501
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit rpn1
- 26S proteasome regulatory subunit rpn2
- Probable 26S proteasome regulatory subunit rpn9
- 26S proteasome regulatory subunit 6B homolog
Sequence:
MSERDTALEKYKSYLLQHREWDSKLKDLRFGNRDLVKKYDKTEDDIKSLQSVGQIIGEVLKQLDSERFIVKASSGPRYVVGCRNNVDQSHLVQGVRVSLDMTTLTIMRILPREVDPLVYNMSIEDPGDISFAGVGGLNEQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVAASLGVNFLKVVSSAIVDKYIGESARIIREMFGYAKEHEPCVIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDYLGQTKIIMATNRPDTLDPALLRPGRLDRKIEIPLPNEVGRMEILKIHLEKVSKQGEIDYEALVKLTDGTNGADLRNVVTEAGFIAIKEDRDYVIQSDLMSAARKVADLKKLEGTIDYQKL
Protein: phosphopyruvate hydratase (EC 4.2.1.11) (Q3HL75)
Organism: Leishmania mexicana
Interaction partners:
Sequence:
MPILKIHAREVLDSRGNPTVEVELTTEAGVFRSAVPSGASTGVHEACELRDGDKARYCGAGCTQAVKYVNEILAPALVGKDESDQAGLDKLMCELDGTKNKSKLGANAILGCSMAISKAAAAKAGVPLYRYIAGLAGTKDMRLPVPCFNVINGGKHAGNVLPFQEFMIAPTKATSFREALRMGSEVYHALKGIIKGKYGQDAVNVGDEGGFAPPIKQIDEPLPILMEAIEKAGHKGKFAICMDCAASEAYDAERKMYNLTFKNPEPTYVSAAKLQETYERWVSEYPLVSIEDPFAEDNFDEFSAITKALAGKAQIVGDDLTVTNVERVKMAIDKSACNSLLLKINQIGTISESIAAAKLCMENGWSVMVSHRSGETEDTYIADLSVGLGTGQIKTGAPCRGERTAKLNQLLRIEEEMGSAAKYGYPGWA
Protein: fructose-bisphosphate aldolase (EC 4.1.2.13) (H3BMQ8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPYQYPALTPEQKKELSDIAHRIVAPGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCV
Protein: Dem protein (Vacuolar import/degradation, Vid27-related protein) (Q9LJK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phosphatidylinositolglycan-like protein
- Probable sugar phosphate/phosphate translocator At3g11320
- GDSL esterase/lipase At5g08460
- ABC transporter C family member 5
Sequence:
MGTSQSREDRISESDTESDSDYYEEEDEDQYDDAKKQGSSSVSGTRPSDSSSSSGPTDSSSLDIEQKLKALKLKYPSSSSVTPKMKNAVKLYRHIGGNTPKAKWIVSDKMTSYKFVKTSSVDGEDIDDYDDCEESGEGGESFWFLGVGTKVKARVSTDMQLKMFGDQRRVDFVSNGVWALKFLTDEDYRKFVTRFQDYLFENVYKIRASEENRVKVYGKDFIGWANPEAADDSMWEDAEAPPEEEETQGKRNTDLTEEFEEVANGGVQSLTLGALDNSFLVNDYGVQVYRNMERGIHGKGVCVRFDSGNSKFGSGSSQTTPNKALLMRAETNMMLMSPAKQGKPNSTGVKQLDIESGKIVTEWKFEKDGTEITMRDITNDTKGSQLDPSESTFLGLDDNRLCQWDMRDRRGIVQNIDSPILEWTQGHQFSRGTNFQCFATTGDGSIVVGSLDGKIRLYSKTSMRMAKTAFPGLGSPITHVDVSYDGKWILGTTDTYLVLICTLFTDKNGLTKTGFSGRMGNKIPAPRLLKLTPLDSHLAGKDNKFHGGHFSWVTESGKQERHIVATVGKFSVIWDLERVKNSAHECYRNQQGLKSCYCYKILLKDESIVESRFMHDNFSFSGNKSPEAPLVVATPLKVSSISLSGKRL
Protein: Pyruvate, phosphate dikinase regulatory protein 2 (EC 2.7.11.32) (EC 2.7.4.27) (Pyruvate, Pi dikinase regulatory protein 2) (AtRP2) (PPDK RP2) (PPDK regulatory protein 2) (Q9MAC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional serine/threonine kinase and phosphorylase involved in the dark/light-mediated regulation of PPDK by catalyzing its phosphorylation/dephosphorylation. Has a much lower phosphotransferase activity than PDRP1. Can use ADP as a high specificity substrate and GDP as a lower affinity substrate, but has no activity with UDP.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17996018}.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 5
- Heavy metal-associated isoprenylated plant protein 7
- Nucleotide-sugar transporter family protein
- E3 ubiquitin-protein ligase MPSR1
- 26S rRNA
Sequence:
MNLHGVSGHHEPNSEPPIPTGSSSPKLKISPKLNRWSRGRALRSGVKLDRPIPRSDNSPRRQVTEAQPTDEADKKTTAIDVEVTAGKSIYLVSDGTGWTAEHSVNAALGQFEDFSLNRGSSVNTHLFSWVEDEERLIEIIKQAAKEGAMCFYTLANPSMAKSAKQACDQLGVLSVDILGPIIEGIASHLGVSPSGLTRGAPGRVKTLNDAYFKRIEAIEFTIKQDDGTLPENLSKADIVLVGVSRTGKTPLSTYIAQKGYKVANVPFVMGVEPPRTLFQVEPRKVFGLKIQLVVLQAIRRTRVKTLGVDTEAENNYSGIDLVRKELDFASRIYERNPGWAVIDVTNKAIEETAAVILRLYHDGRDTSTTVPRISKRY
Protein: Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (P9WFW7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00036}.
Interaction partners:
- Putative pre-16S rRNA nuclease
- Phenylalanine--tRNA ligase beta subunit
- Endolytic murein transglycosylase
- Tetratrico peptide repeat group 5 domain-containing protein
- Sulfotransferase
- Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3
- Probable shikimate 5-dehydrogenase AroE
- Leucine--tRNA ligase
- Threonine--tRNA ligase
- PE-PGRS family protein PE_PGRS62
Sequence:
MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFVPFFLGQRTPPYPTATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKRGAIELAWALLTNSLAAGGYGLDPERIWTTVYFDDDEAVRLWQEVAGLPAERIQRRGMADNYWSMGIPGPCGPSSEIYYDRGPEFGPAGGPIVSEDRYLEVWNLVFMQNERGEGTTKEDYQILGPLPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARVAARAYDVGNHEDDVRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAIVGDLMATVRNAMGPSYPELVADFERISRIAVAEETAFNRTLASGSRLFEEVASSTKKSGATVLSGSDAFTLHDTYGFPIELTLEMAAETGLQVDEIGFRELMAEQRRRAKADAAARKHAHADLSAYRELVDAGATEFTGFDELRSQARILGIFVDGKRVPVVAHGVAGGAGEGQRVELVLDRTPLYAESGGQIADEGTISGTGSSEAARAAVTDVQKIAKTLWVHRVNVESGEFVEGDTVIAAVDPGWRRGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGPLTDDQRTQVEEVTNEAVQADFEVRTFTEQLDKAKAMGAIALFGESYPDEVRVVEMGGPFSLELCGGTHVSNTAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLKVPSEEVPARVANLVERLRAAEKELERVRMASARAAATNAAAGAQRIGNVRLVAQRMSGGMTAADLRSLIGDIRGKLGSEPAVVALIAEGESQTVPYAVAANPAAQDLGIRANDLVKQLAVAVEGRGGGKADLAQGSGKNPTGIDAALDAVRSEIAVIARVG
Protein: Ankyrin repeat domain containing 11 (A0A2R8Y438)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQKDSDTGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDT
Protein: GATOR2 complex protein WDR24 (A0A3B3ISA1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSVLSCRILRLHHSFAHGPMQDAESTANDAREYVLQITWCPAPGPRLLWRLCVAASLGRSWGCPLYPLGLCSGPQAGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS
Protein: Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neutrophic factor) (HBNF) (Osteoblast-specific factor 1) (OSF-1) (P32760)
Organism: Gallus gallus (Chicken)
Function: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P21246}.
Interaction partners:
- Tyrosine-protein kinase receptor.
- Protein-tyrosine-phosphatase.
- Syndecan-3
- Tyrosine-protein kinase receptor.
- Heparin binding growth factor.
Sequence:
MPQQQQQRRMFTAALLALVFILAAVSTTEAGKKEKPEKKAKKSDCGEWQWSVCVPTNGDCGLGTREGTRTGAECKQTTKTQKCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGNLKRALHNADCQKTVTISKPCGKLTKPKPQESKKKKKEGKKQEKMLD
Protein: Transposon Ty2-C Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)] (P25384)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLHQNPRSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYQRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTHTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQDKQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSINPLQLDKEPVQKVRAPKEVDADISEYNILPSPVRSRTPHIINKESTEMGGTVESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAVCDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTHQSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNKDNKEKDRYVEAYHKEISQLLKMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: Breast cancer metastasis-suppressor 1 homolog (Q99N20)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.
Interaction partners:
- AT-rich interactive domain-containing protein 4A
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
- Histone deacetylase complex subunit SAP30L
- Histone deacetylase complex subunit SAP30
- SIN3-HDAC complex-associated factor
- Inhibitor of growth protein 2
- AT-rich interactive domain-containing protein 4B
- Histone-binding protein RBBP4
- Paired amphipathic helix protein Sin3b
Sequence:
MPIQPSGKETEEMEAEGDSAAEMNGEADESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQQSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKMLLYDTLLGELQERIQRLEEDRQSLDISSEWWDDKLHSRSSSKAGDAMPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKADGP
Protein: Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) (Q8K4B2)
Organism: Mus musculus (Mouse)
Function: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29686383}. Nucleus {ECO:0000269|PubMed:29686383}. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000269|PubMed:29686383}.
Interaction partners:
- Interleukin-1 receptor-associated kinase-like 2
- Interleukin-1 receptor-associated kinase 4
- Interleukin-1 receptor-associated kinase 1
- TNF receptor-associated factor 6
- Myeloid differentiation primary response protein MyD88
- Tumor necrosis factor receptor superfamily member 16
- Toll-interacting protein
- Single Ig IL-1-related receptor
- Toll-like receptor 2
- Toll-like receptor 4
Sequence:
MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIHLIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNVLVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNHSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ
Protein: Uncharacterized oxidoreductase YgfF (EC 1.-.-.-) (P52037)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized oxidoreductase YgjR
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjJ
- Uncharacterized protein YggP
- NADH-quinone oxidoreductase subunit C/D
- Uncharacterized oxidoreductase YdgJ
Sequence:
MAIALVTGGSRGIGRATALLLAQEGYTVAVNYQQNLHAAQEVMNLITQAGGKAFVLQADISDENQVVAMFTAIDQHDEPLAALVNNAGILFTQCTVENLTAERINRVLSTNVTGYFLCCREAVKRMALKNGGSGGAIVNVSSVASRLGSPGEYVDYAASKGAIDTLTTGLSLEVAAQGIRVNCVRPGFIYTEMHASGGEPGRVDRVKSNIPMQRGGQAEEVAQAIVWLLSDKASYVTGSFIDLAGGK
Protein: Proton channel OTOP2 (Otopetrin-2) (Q80SX5)
Organism: Mus musculus (Mouse)
Function: Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSEELVPHPNESLPGPRASPREVWKKGGRLLSVLLAVNVLLLACTLISGGAFNKVAVYDTDVFALLTTMMLLAALWIVFYLLRTARCPDAVPYRDAHAGPIWLRGGLVLFGICTLVMDVFKTGYYSSFFECQSAIKILHPIIQAVFVIVQTYFLWISAKDCIHTHLDLTRCGLMFTLATNLAIWMAAVVDESVHQAHSYSGSHGNTSHTRLNPDSKRAGGAAEEDPCLCSTAICQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRLLASTHGHGHTPSRVSLFRETFFAGPVLGLLLFVVGLAVFILYEVQVSGERGHTRQALVIYYSFNIVCLGLMTLVSLSGSVIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVVGSPRDLQGALNLSHALLMIAQHTFQNVFIIESLHRGPPGAEPREMPPKEPCQGITFANLDAIRTLPSCPPTPRLVIPNLESPQEAVAIISAPRCHWRRRCLKDISLFLLLCNVILWIMPAFGARPHFSNTVEVDFYGYSLWAAIVNICLPFGIFYRMHAVSSLLEVYVLS
Protein: Armadillo repeat only 2 (Q9FKW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Arogenate dehydratase/prephenate dehydratase 2, chloroplastic
- Anthranilate synthase alpha subunit 2, chloroplastic
- Telomere repeat-binding protein 2
- Rac-like GTP-binding protein ARAC4
Sequence:
MADIVKQILAKPIQLSDQVVKAADEASSFKQECGELKAKTEKLAGLLRQAARASNDLYERPTRRIIDDTEQMLEKALSLVLKCRANGLMKRVFTIIPAAAFRKMSGQLENSIGDVSWLLRVSAPAEDRGDAGYLGLPPIAANEPILCLIWEQIAILYTGSLEDRSDAAASLVSLARDNDRYTKLIIEEGGVVPLLKLLKEGKPEGQENAARALGLLGRDPESVEHMIHGGACSVFGKVLKEGPMKVQAVVAWATSELVSNHPKCQDVFAQHNAIRLLVGHLAFETVQEHSKYAIATNNKATSIHHAVALAKENPNSTSATALPKGLDEDQSSIPHPTGKQMPNQMHNVVVNTMAVRANPPRKSTSNGVSQSNGVKQPSSVQQHQNSTSSASKTRELEDSATKCQIKAMAARALWKLAKGNSTICKSITESRALLCFAVLIEKGDEEVRYNSAMALMEITAVAEQDADLRRSAFKPNSPACKAVVDQVLRIIEIADSELLIPCIRTIGNLARTFRATETRMIGPLVKLLDEREPEVTGEAAAALTKFACTANYLHKDHSRGIIEAGGGKHLVQLAYFGEGGVQIPALELLCYIALNVPDSEQLAKDEVLAVLEWASKQSWVTQLESLEALLQEAKRGLDLYQQRGSRGYNFN
Protein: Ribosome maturation protein sdo1 (O14179)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase ria1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome assembly protein 1
- Eukaryotic translation initiation factor 6
- Ribosome biogenesis protein nsa2
- Ribosome biogenesis protein rlp24
- Ribosome assembly factor mrt4
- Ribosome biogenesis protein ytm1
- Cytoplasmic 60S subunit biogenesis factor SPCC550.15c
- Large ribosomal subunit protein uL30A
- 60S ribosome subunit biogenesis protein nip7
- Nucleolar protein 16
Sequence:
MVISQPVGQIRLTNVSVVKYKKGGKRFEVACYKNKVTEWRNKIETDLDEVLQIHNVFNNVSKGHVASRQDLKKAFGTDDIDKIILEILQKGDFQVGEKERHHQMSSTYRDIVSHVTAMCMDPNSKRPYPASIIEKALSDCGFSVSTSKTAKSQALEAIKKLQEKNEIPIVRARMRIRIVVDVKQGKALRERLRSLADEIEEENIDDEYECIALVIPGNYKLIDELVRNETKNRGMVQVLDMSEART
Protein: Probable glucan 1,3-alpha-glucosidase (EC 3.2.1.84) (Glucosidase II subunit alpha) (Protein PRIORITY IN SWEET LIFE 5) (Protein RADIAL SWELLING 3) (Q9FN05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Essential for stable accumulation of the receptor EFR that determines the specific perception of bacterial elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Required for sustained activation of EFR-mediated signaling, but not receptor FLS2-mediated signaling elicited by the bacterial flagellin flg22.
Subcellular location: Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Glucosidase 2 subunit beta
- Mannosyl-oligosaccharide glucosidase GCS1
- Expressed protein
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3
- Alpha-glucosidase 2
- UDP-glucose:glycoprotein glucosyltransferase
- Calnexin homolog 2
- Calnexin homolog 1
- Endoplasmic reticulum oxidoreductin-2
- Cellulose synthase A catalytic subunit 1
Sequence:
MRSLLFVLSLICFCSQTALSWKKEEFRSCDQTPFCKRARSRTPGACSLIVGDVSITDGDLVAKLLPKAPNQGDGDQIKPLILSLSVYKDGIVRLKIDEDHSLNPPKKRFQVPDVVVSEFEEKKIWLQKVATETISGDTSPSSVVYVSDGYEAVVRHDPFEVYVREKSGDRRRVVSLNSHGLFDFEQLGRKTEGDNWEEKFRTHTDSRPSGPQSISFDVSFYDSSFVYGIPEHATSFALKPTKGPGVEESEPYRLFNLDVFEYDHESPFGLYGSIPFMVSHGKSGKTSGFFWLNAAEMQIDVLANGWDAESGISLPSSHSRIDTFWMSEAGIVDTFFFVGPEPKDVVKQYASVTGTSAMPQLFATGYHQCRWNYKDEEDVAQVDSKFDEHDIPYDVLWLDIEHTDGKRYFTWDSVLFPHPEEMQKKLAAKGRKMVTIVDPHIKRDDSYFLHKEATQMGYYVKDSSGKDFDGWCWPGSSSYIDMLSPEIRKWWGGRFSYKNYVGSTPSLYTWNDMNEPSVFNGPEVTMPRDALHVGGVEHREVHNAYGYYFHMATSDGLVMREEGKDRPFVLSRAIFPGTQRYGAIWTGDNTAEWEHLRVSIPMILTLGLTGITFSGADIGGFFGNPEPELLVRWYQVGAYYPFFRGHAHHDTKRREPWLFGERNTELMRDAIHTRYTLLPYFYTLFREANVTGVPVVRPLWMEFPQDEATFSNDEAFMVGSGLLVQGVYTKGTTQASVYLPGKESWYDLRNGKTYVGGKTHKMDAPEESIPAFQKAGTIIPRKDRFRRSSSQMDNDPYTLVVALNSSQEAEGELYIDDGKSFEFRRGSYIHRRFVFSKGVLTSTNLAPPEARLSSQCLIDRIILLGHSSGPKSALVEPLNQKAEIEMGPLRMGGLVASSGTKVLTIRKPGVRVDQDWTVKIL
Protein: Cytochrome P450 20A1 (EC 1.14.-.-) (Q6UW02)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY
Protein: Protein METHYLENE BLUE SENSITIVITY 2 (Q9FFD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for acclimation to reactive oxygen species (ROS) responses downstream of beta-cyclocitral, including singlet oxygen 1O(2) detoxification reactions, especially upon light-mediated photooxidative stress, and leading to programmed cell death (By similarity). Prevents leaf senescence.
Subcellular location: Nucleus {ECO:0000269|PubMed:24151292}. Cytoplasm {ECO:0000269|PubMed:24151292}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q9M8S0}. Note=Moves from homogeneous distribution in the cytosol to discrete spots (e.g. stress granules (SGs) and processing bodies (PBs)) in response to singlet oxygen 1O(2) exposure. {ECO:0000250|UniProtKB:Q9M8S0}.
Interaction partners:
- C2H2-like zinc finger protein
- C2H2-like zinc finger protein
- DDE family endonuclease
Sequence:
MTGKAKPKKHTAKELQAKADAALTNRGGGKAGLADRTGKEKGGHAKYECPHCKITVPDLKTMQIHHESKHPKLTYEEPRNLHEALAAPAESSKPKPGIRGSLKK