wanglab/gogpt-training-data huggingface dataset:
Protein: GTP-binding protein YPT1 (Protein YP2) (Rab GTPase YPT1) (Transport GTPase YPT1) (P01123)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. YPT1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Vesicular transport depends on shuttling of YPT1 between membrane and cytosol by GDI1, probably by recycling it to its membrane of origin after a vesicle fusion event. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12802060}; Peripheral membrane protein {ECO:0000269|PubMed:12802060}. Golgi apparatus membrane {ECO:0000269|PubMed:12802060}; Peripheral membrane protein {ECO:0000269|PubMed:12802060}. Cytoplasm {ECO:0000269|PubMed:12802060}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20375281}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=ER and Golgi when GTP-bound. Cytoplasmic when bound to GDI1.
Interaction partners:
- Trafficking protein particle complex subunit BET5
- Trafficking protein particle complex subunit BET3
- Rab GDP-dissociation inhibitor
- Trafficking protein particle complex subunit 23
- Ras-related protein SEC4
- Intracellular protein transport protein USO1
- Trafficking protein particle complex III-specific subunit 85
- Trafficking protein particle complex subunit 20
- Trafficking protein particle complex subunit 33
- Vacuolar protein sorting-associated protein 33
Sequence:
MNSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMWLQEIDRYATSTVLKLLVGNKCDLKDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKKEDKGNVNLKGQSLTNTGGGCC
Protein: Kinesin-like protein (Q8MQ04)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSSRKRGITPSRDQVRRKKLSIEETDSIEVVCRLCPYTGSTPSLIAIDEGSIQTVLPPAQFRRENAPQVEKVFRFGRVFSENDGQATVFERTSVDLILNLLKGQNSLLFTYGVTGSGKTYTMTGKPTETGTGLLPRTLDVIFNSINNRVEKCIFYPSALNTFEIRATLDAHLKRHQMAADRLSTSREITDRYCEAIKLSGYNDDMVCSVFVTYVEIYNNYCYDLLEDARNGSRVLTKREIRHDRQQQMYVDGAKDVEVSSSEEALEVFCLGEERRRVSSTLLNKDSSRSHSVFTIKLVMAPRAYETKSVYPTMDSSQIIVSQLCLVDLAGSERAKRTQNVGERLAEANSINQSLMTLRQCIEVLRRNQKSSSQNLEQVPYRQSKLTHLFKNYLEGNGKIRMVICVNPKPDDYDENMSALAFAEESQTIEVKKQVERMPSERIPHSFFTQWNSELDGSVRMEDDGSREIPCPPTFCLTDCNDKDTVDSMYKYARKLSSLQNSSEEGPSSTLLTMIRQYMMEADYQRVEIARLKDSLNDKDEEIKKLRGFCSRYKRENASMKERIASCEQGEQENALVMEKLMEQKMEDRKIIQSQKKAMRNVRGIIDNPSPSVASLRSRFDQENVAHPTAPIQTPPPPYQTPGRAPVFKKRLEATTSTTVMSGSSSGGSGQQGYVNPKYQRRSKSASRLLDHQPLHRVPTGTVLQSRTPANAIRTTKPEMHQLNKSGEYRLTHQEVDDEGNISTNIVKGNVIPTVSGGTAVFFNDIERLTHESPSTRK
Protein: HTH-type transcriptional regulator MetR (P0A9F9)
Organism: Escherichia coli (strain K12)
Function: Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negative regulator of its own expression. Binds homocysteine as an inducer.
Subcellular location: Cytoplasm.
Interaction partners:
- 5,10-methylenetetrahydrofolate reductase
- Cystathionine gamma-synthase
- Methionine aminotransferase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Met repressor
- Hydroxycarboxylate dehydrogenase A
- Homoserine O-succinyltransferase
- Methionine import ATP-binding protein MetN
- Cystathionine beta-lyase MetC
- S-adenosylmethionine synthase
Sequence:
MIEVKHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQISQALQACNEPQQTRLRIAIECHSCIQWLTPALENFHKNWPQVEMDFKSGVTFDPQPALQQGELDLVMTSDILPRSGLHYSPMFDYEVRLVLAPDHPLAAKTRITPEDLASETLLIYPVQRSRLDVWRHFLQPAGVSPSLKSVDNTLLLIQMVAARMGIAALPHWVVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARNHACDHLPFVKSAERPTYDAPTVRPGSPARL
Protein: Protein dif-1 (Q27257)
Organism: Caenorhabditis elegans
Function: Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Calponin-homology
- PNPLA domain-containing protein
- Zinc finger CCCH-type with G patch domain-containing protein
- Choline/carnitine acyltransferase domain-containing protein
- Choline O-acetyltransferase
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- MaoC-like domain-containing protein
- Probable enoyl-CoA hydratase, mitochondrial
- Gamma-secretase subunit aph-1
Sequence:
MSDVLLNFIAGGVGGSCTVIVGHPFDTVKVRIQTMPMPKPGEKPQFTGALDCVKRTVSKEGFFALYKGMAAPLVGVSPLFAVFFGGCAVGKWLQQTDPSQEMTFIQNANAGALAGVFTTIVMVPGERIKCLLQVQQAGSAGSGVHYDGPLDVVKKLYKQGGISSIYRGTGATLLRDIPASAAYLSVYEYLKKKFSGEGAQRTLSPGATLMAGGLAGIANWGVCIPADVLKSRLQTAPEGKYPDGIRGVLREVLREEGPRALFKGFWPVMLRAFPANAACFFGLELTLAAFRYFGIGGHPTPSTEVVPLPHDE
Protein: Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Q9D9E0)
Organism: Mus musculus (Mouse)
Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Upon LCN2-binding, it is internalized. {ECO:0000250}.
Interaction partners:
- Neutrophil gelatinase-associated lipocalin
- Low-density lipoprotein receptor-related protein 2
Sequence:
MPSARFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQELENTCPLPATSTFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDAAITTFSVLGLFSSQASAILSTLLASEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPNRCDHVPLLATPNPAL
Protein: Probable helicase with zinc finger domain (EC 3.6.4.-) (Q6DFV5)
Organism: Mus musculus (Mouse)
Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histone-lysine N-methyltransferase SMYD3
Sequence:
MEDRRAERSCEQACASLQRQDYDMALQHCTDALLSLGQYSMADFTGPCPVEVERIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGERAFRAVLCCMQLKGKLQLVSSILAKSLSGESLNGMVTKDLTRLKTLLTETETATSNVLSGCHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKRQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQARLHDLLYIEEIAQYKEVSRFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISRECCEELSLRPDCDIQVELQFQLNRLPLCEMHYALDRIKDNAVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAAKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSTQSTFQMPQKEDILKHRVVVVTLSTSQYLCQLDLEPGFFTHVLLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGNSSRQQQSPPKVKSLYHPQSDHFQSDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVSLGQPQSQHAEKDQQEQNRNGKTDTNNPGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPGVVYSNTKFPRKDHLNPRHINNLPLPAPHAQYAIPSRHFHPLPQLPRPPFPASQPHTLLNQQQNNLPEQPNQMAPQPNQVAPQPNQMTPQPNQVAPQPNQVVQQQSQAPPQAPQPAPQLSPAFQAGPTNAFFNNAVAHRPQSPAAEAVGPEQPPPPGLPDGHSPLRAITQPGPILASPLNNFVDESSPGLPIEEALDGVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHHHHPHLPHLPHTPIGLHQPPVRAEWKVAGRADDETETTFSRFQDLLRELSHRDQGDTGELAEMPPPQSRLLQYRQVQPRSPPAVPSPPSSTDHSSQFANFNDSSRDIEVANSPAFPQRLPPQLFGSPFSLPSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQNHQHAAGQEPFHPLSSRTVSASSLPSLEEYEPRGPGRPLYQRRISSSSAQPCVEEASAPQDSLAQGKESQGHSNPPAFNFPAPESWANTTSSAPYQNIPCNGSSRTSQPRELIAPPKTVKPPEDQLKPESGEVSSSFNYSMLQHLGQFPPLMPNKQIAESANCSSQQSPAGSKPAMSYASALRAPPKPRPPPEQAKKGSDPLSLLQELSLGSSPGSNGFYSYFK
Protein: Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Q9EQU5)
Organism: Mus musculus (Mouse)
Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium (By similarity). {ECO:0000250}.
Interaction partners:
- Acidic leucine-rich nuclear phosphoprotein 32 family member A
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Exportin-1
- Chromobox protein homolog 3
- Nuclear pore complex protein Nup214
- Prostaglandin E synthase 3
- Microcephalin
- Tumor necrosis factor ligand superfamily member 13
- SET-binding protein
- Serine/arginine-rich splicing factor 6
Sequence:
MAPKRQSAILPQPKKPRPAAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
Protein: Stretchin-Mlck, isoform B (EC 2.7.11.17, EC 2.7.11.18) (A1ZA69)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSQLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTTRTYTSLLVLPAIRGNSSSSSLAARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKVIWYKACHPIVESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRFRVRAENIHGRSAPGQASELVQITNTPQRSTSSDASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLSQRPDDSLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLELPTKGEAIMRSDFTNTIKMRKKSLEDSAAREKPRSKPQVKPLLCESKLKVSQLKDRFQVSPAPASASASASAANKPPLAYGPFKIAKVASVGRISRTEEPGRSGRGAPSVSGKGKSPQVRSMPSSPLPQRSATPTRLMSQRVREAAERLAQQHTVASAQRHLGNGRGTGTGNGNGNSNSNGNGNGNTAETNRESRARRLINRFNSETQHITS
Protein: E2 ubiquitin-conjugating enzyme (Q9N490)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLNLGPGVSVPAAGTASSSAVRRLQKDYAKLMQDPVDGIKALPNEDNILEWHYCLRGSPDTPFYGGYYWGKVIFKENFPWSPPAITMITPNGRFQTNTRLCLSISDYHPESWNPGWTVSAILIGLHSFMNENSPAAGSIAGTPQDQRMYAAASKEFNVKVYNWNLAGNPHCNFFLTRDEEKWFLGHGRGADKFHRPFILLCFPPVFFCFSSIFPVFSY
Protein: Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) (Q9Z1D1)
Organism: Mus musculus (Mouse)
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03006}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03006}. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region. {ECO:0000255|HAMAP-Rule:MF_03006}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit H
Sequence:
MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLPTGDTSPEPELLPGDPLPPPKEVINGNIKTVTEYKIEEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQAAQSKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN
Protein: Wee1-like protein kinase 2-A (EC 2.7.10.2) (Maternally supplied wee1-like protein kinase 1A) (Xe-wee1A) (P47817)
Organism: Xenopus laevis (African clawed frog)
Function: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', which inhibits cdk1 activity and prevents meiotic reentry. Negative regulator of mitosis. Involved in the mitotic DNA replication checkpoint.
Subcellular location: Nucleus {ECO:0000269|PubMed:15583029}. Cytoplasm, cytosol {ECO:0000269|PubMed:15583029}.
Interaction partners:
Sequence:
MRTAMSCGGGLVQRLDFSSSDEEDGLSNGINEGPQKGSPVSSWRTNNCPFPITPQRNERELSPTQELSPSSDYSPDPSVGAECPGTPLHYSTWKKLKLCDTPYTPKSLLYKTLPSPGSRVHCRGQRLLRFVAGTGAELDDPSLVNINPFTPESYRQTHFQPNGKRKERPEDDCRTDRQMKYAEKEHPAVFQSKRFVLRETNMGSRYKTEFLEIEKIGAGEFGSVFKCIKRLDGCFYAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCNGGSLQDLIVDNNKEGQFVLEQELKEILLQVSMGLKYIHGSGLVHMDIKPSNIFICRKQTELGQEESDGEDDLSSGSVLYKIGDLGHVTSILNPQVEEGDSRFLANEILQEDYSQLPKADIFALGLTIALAAGAAPLPCNEDSWHHIRKGNLPHVPQLLTPIFLALLKLLVHPDPVMRPPAASLAKNSVLRRCVGKAAQLQKQLNVEKFKTAMLERELKAAKLAQTSGKDECSDLPPMSGFSCRGRKRLVGAKNTRSLSFTCGGY
Protein: Growth arrest-specific protein 1 homolog (Pharynx-associated gas1 homolog) (Q09553)
Organism: Caenorhabditis elegans
Function: Role in pharynx function or development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11955608}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11955608}. Note=Localized on the muscle cell plasma membrane.
Interaction partners:
Sequence:
MRRVILPLVMTVTLCLAQEASEACTKALTDCENDLECQNRLAPLMAACSTNTCQPQCRSAVLNVYQNKLGRILLRSDATCIPGRDELRTCNFLPAESTVHCSLGKLACEGDLQCNSKFGVFMSECEADAARGACTDKCKTLLNQTIETSVGSVFSNCTCTARDDQLCTNLKDNLLGVCLKNTPGVTLSPSDNSITDAPGGNDLADSSVGHGFNILSAISVYLLTVLVF
Protein: Ground-like domain-containing protein (O16462)
Organism: Caenorhabditis elegans
Interaction partners:
- GRounDhog
- Ground-like domain-containing protein
- Ground-like domain-containing protein
- Ground-like domain-containing protein
- Ground-like domain-containing protein
- Ground-like domain-containing protein
- WaRThog
- Ground-like domain-containing protein
- Ground-like domain-containing protein
- Ground-like domain-containing protein
Sequence:
MRSLIVLAALAVTVCFAQDNCYINDSGFTCCNKELESAMKGAMGGDDLLGSADSIQKGAEGSLGGKFETVVALDDFAYKSHFKEGKSCKIEKNGQYALAWQP
Protein: Guanine nucleotide-binding protein subunit beta (WD40 repeat-containing protein 80) (OsWD40-80) (Q40687)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22429805}.
Interaction partners:
- Os02g0329300 protein.
- Guanine nucleotide-binding protein alpha-1 subunit
- Os04g0589400 protein
- G-protein alpha subunit, putative, expressed
- Os12g0593000 protein
- Os10g0117800 protein
- Os06g0111400 protein
- Guanine nucleotide-binding protein alpha subunit
- Os10g0372500 protein
- Expressed protein
Sequence:
MASVAELKEKHAAATASVNSLRERLRQRRQMLLDTDVERYSRTQGRTPVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMTCAFAPNGQSVACGGLDSACSIFNLNSQADRDGNIPVSRILTGHKGYVSSCQYVPDQETRLITSSGDQTCVLWDVTTGQRISIFGGEFPSGHTADVLSLSINSSNSNMFVSGSCDATVRLWDIRIASRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDVRTGHQLQVYSREPDRNDNELPTVTSIAFSISGRLLFAGYSNGDCYVWDTLLAEVVLNLGNLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGHRKIV
Protein: Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) (P47823)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287}.
Interaction partners:
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit 3
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 1
- dTDP-D-glucose 4,6-dehydratase
- Selenocysteine-specific elongation factor
- eIF-2-alpha kinase GCN2
Sequence:
MATTVVAPPGAVSDRANKRGGGPGGGGGGGGARGAEEESPPPLQAVLVADSFNRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVVSNINVTRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSATNRILHFQKTQGLRRFSFPLSLFQGSGAGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTTREYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTDSTAQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCSITNSVIGPGCCIGDNVVLDRAYLWKGVQVASGAQIHQSLLCDHAEVKEQVTLKPHCVLTSQVVVGPNITLPEGSVISLHPPDAEEDEDDGQFSDDSGVNQAKEKAKLKGYNPAEVGVAGKGYLWKAADMNTEKEEELRQSLWGLTINEEEESETESERSMDSEELDSRAGSPQLDDIKVFQNEVLGTLQRGKEESISCDNLILEINSLKYAYNISLKEVMQVLSHVVLEFPLQQMDSPLEANRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEEFFLEHEALGTCIAKVLMGFYQLEILAEETILSWFGQRDVTDKGRQLRKNQQLQRFIQWLKEAEEESSEDD
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (E1BIM8)
Organism: Bos taurus (Bovine)
Interaction partners:
- Estrogen receptor
- Paxillin
- Signal transducer and activator of transcription 3
- Caveolin-1
- Focal adhesion kinase 1
- Integrin beta
- Vinculin
- Receptor protein-tyrosine kinase
- Src substrate cortactin
- Adapter molecule crk
Sequence:
MGGCPMGREHSQGGVGAGLPWPVPPPFHSLAAGTPGVGRPRAGLSQVTGGDSSRHASSFLPLPAGPLLPARALPPSSSPPRAAASSSSSASLSLSICLSRPGIHSGPGAGAARPPCARTTGRPAVRLPVRLSARCVRLPAGPVSRTMGSNKSKPKDASQRRRSLESAENTHGGGGGGGGGGGAFPSSQTPSKPASSDGHRGPNTAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLSGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGESLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Protein: RNA helicase (EC 3.6.4.13) (K7ENP6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGM
Protein: Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Q61324)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9HBZ2, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Hypoxia-inducible factor 1-alpha
- Neuronal PAS domain-containing protein 4
- Endothelial PAS domain-containing protein 1
- Aryl hydrocarbon receptor nuclear translocator
- Hypoxia-inducible factor 3-alpha
- Aryl hydrocarbon receptor
- Single-minded homolog 1
- Single-minded homolog 2
- Aryl hydrocarbon receptor repressor
- Basic helix-loop-helix ARNT-like protein 1
Sequence:
MATPAAVNPPEMASDIPGSVALPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEIEYVICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGKAFSSSVVHVPGVNDIQSSSSTGQNISQISRQLNQGQVAWTGSRPPFPGQPSKTQSSAFGIGSSHPYPADPSSYSPLSSPAASSPSGNAYPSLANRTPGFAESGQSGGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE
Protein: Cyclin delta-3 (F4JJY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGSISMHITPSTALPIRHFRARVSCCSSGNFVFPPFVRIACDCRIIVIVDCLMAFQIEKMLELISLLSILEQSFVGKCSDYDWHVSFIKDVAATEPPMHLHHLLKVLQTRGETIISPGAKQGLIPLAIPLSKNSSGSVTALLRWPTAPPGMDMPVVEVWRSGVRLIARNVDEYIHRILVEEDAQELTELYRASGEAGEKLYEKGAFAESEIDNLDVYVLKKVGLFPDLLERKVLRHFDEGDHVSAMVTGEFYTKKDLFPGFGRPFVYYANILQKFILIRRVGRNVEAKDAARVALRSPWWTLGCPYEEVASIAQWEDEQIEFIREKVSDEGRFEDLHKGKAPIQVALDVAAFLLDLASIEGTWSESLNHIAKCYEEAGLHHISNFVLYTD