wanglab/gogpt-training-data huggingface dataset:
Protein: Multidrug efflux system ATP-binding protein Rv1218c (EC 7.6.2.-) (O86311)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable).
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Multidrug efflux system permease protein Rv1217c
- HTH-type transcriptional regulatory protein RaaS
- Transport permease protein
- Probable conserved integral membrane protein
- Conserved protein
- Sulfate/thiosulfate import ATP-binding protein CysA
- Doxorubicin resistance ABC transporter permease protein DrrB
- Multidrug efflux pump Tap
- Probable doxorubicin resistance ABC transporter permease protein DrrC
- Fatty acid ABC transporter ATP-binding/permease protein
Sequence:
MSADNHQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPNGAGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWPSLTGGETIDLLARMRGGIDNARRAELIERFGLDPTKKARTYSKGNRQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVLLSSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPGDLSQIKGVEDISIEGTTVRAQVDSESLRELIQVLGHAGVRSLVSQPPTLEELFLRHYSLGPEVAAEQQVATP
Protein: Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) (Q96MS3)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MRLLFLAVLRPHTGNAVTAQRVRAHLEAAGHVCVLKDAFDFESRSEIANLILAENCEAALALHLYRGGRLLQGHRIPFGVIFGGTDVNEDANQAEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIATTPNAAFNWNTFLQRSEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKLEGSTED
Protein: glutamine--fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) (Q7PLC7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glucosamine-6-phosphate deaminase
- Glucose-6-phosphate isomerase
- Probable glucosamine 6-phosphate N-acetyltransferase
- N-acetylglucosamine-6-phosphate deacetylase
- Multifunctional protein r
- Glutamate synthase
- Glutamine synthetase 2 cytoplasmic
- Glutamine synthetase 1, mitochondrial
- mannose-6-phosphate isomerase
- Amidophosphoribosyltransferase
Sequence:
MCGIFAYLNYLTPKSRQEVLDLLVTGLKRLEYRGYDSTGVAIDSPDNKNIVMVKRTGKVKVLEEAIQEHFSGREYSEPVLTHVGIAHTRWATHGVPCEKNSHPHRSDDENGFVVVHNGIITNYNDVKTFLSKRGYEFESDTDTEVFAKLVHHLWKTHPTYSFRELVEQAILQVEGAFAIAVKSKYFPGECVASRRSSPLLVGIKTKTRLATDHIPILYGKDDKKLCTDQDADSGKPQDIRPHGQSRELPVLPRSESTSEFMPLEEKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVRDGTLSIHRLKKSLDDPHAREITTLKMEIQQIMKGNYDYFMQKEIFEQPDSVVNTMRGRVRFDGNAIVLGGIKDYIPEIKRCRRLMLIGCGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYCKQRGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQRRLEILQALSKLADQIRDVLQLDSKVKELAKDLYQHKSLLIMGRGYNFATCLEGALKVKELTYMHSEGIMAGELKHGPLALVDDSMPVLMIVLRDPVYVKCMNALQQVTSRKGCPIIICEEGDEETKAFSSRHLEIPRTVDCLQGILTVIPMQLLSYHIAVLRGCDVDCPRNLAKSVTVE
Protein: High-affinity nickel-transport family protein (F4JM82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Annexin D7
- Pentatricopeptide repeat-containing protein At5g14770
Sequence:
MERLLQPSSSSSSISPSKFPSRTSPFLPRLRSSGLSFVSTHRPESRRVSSISCNSSQIPSLYTPIGSNTTNNSFNGSPKSDESKPNPGFLTRIATSASEQRKETYEKFVYSLLEKKIPRITKSSNFTLSTGTVILISAVAVLLLNPLLAPPAFASFQTAAKSGWLTSAWTGFLAGCLHTLSGPDHLAALAPLSIGRSKMESAAVGALWGCGHDAGQVIFGLLFLLLKDRLHIEVLQTWGTRIVGLTLVIIGAMGIKEASEIPEPCVALETDISMVSTEKEALPLPKKKKIGFATFATGVVHGLQPDALMIVLPALALPSRLAGSAFLIMFLVGTVIAMGSYTAFIGSCSEALKEKVPRITEKLTWVSSLVAIGLGLGIVISPFFGFSLY
Protein: Orotidine 5'-phosphate decarboxylase (EC 2.4.2.10) (EC 4.1.1.23) (OMP decarboxylase) (Q57U85)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Dihydroorotate dehydrogenase
- Predicted S. cerevisiae Got1 homologue
- uracil phosphoribosyltransferase
- aspartate carbamoyltransferase
- Carbamoyl phosphate synthase arginine-specific large chain
- ribose-phosphate diphosphokinase
- ribose-phosphate diphosphokinase
- ribose-phosphate diphosphokinase
- Ribose-phosphate pyrophosphokinase, putative
- Nucleoside diphosphatase, putative
Sequence:
MSSTFFDMLNKRAKTTLLCIGLDPRADTAAAAVLECKRIIDTTSNYAAAYKPNAAFFECFGAAGWSALEEVIAHIPQDIPVLLDAKRGDIADTAEAYAKSAFQRLKVHAITASPYMGGDSLQPFLKYSSKGVFVLCKTSNKGSSELQCLQTNGQSLYETIAERAERVWNYNRNVGLVVGATDPVALSRARACAPTLWILVPGVGAQGGDLKAALQAGLRTDGSGLLINVSRAVTQAKDPRAVAQKLCEDINRIRLRTNNVSEMAGALVASQCVRFGKFTLKSGKTSPIYIDLRRLVTHPLIMRLVARHYARILTTMQFDRIVGLPYAALPIATAISLEMNVPLIYPRRERKDYGTKGLIEGDFQKGDRVVIVDDLVTTGETKVEAIEKLKAAGLHIVSIVVLIDREMGAKKFLGSLGYEFHAVATLSQLLPLWLQQGAITDKQMREVTAFMLESTSKL
Protein: Beta-1,3-galactosyltransferase GALT1 (EC 2.4.1.-) (Beta-1,3-galactosyltransferase 15) (Galactosyltransferase 1) (Q8L7F9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of N-glycans containing Lewis a structures (with the combination of FUT13).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:17630273, ECO:0000269|PubMed:23400704}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-
- Glycoprotein 3-alpha-L-fucosyltransferase A
- Putative fucosyltransferase-like protein
- Alpha-mannosidase 2
- Beta-1,6-galactosyltransferase GALT31A
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Beta-1,2-xylosyltransferase
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Beta-1,6-galactosyltransferase GALT29A
- Beta-arabinofuranosyltransferase RAY1
Sequence:
MKRFYGGLLVVSMCMFLTVYRYVDLNTPVEKPYITAAASVVVTPNTTLPMEWLRITLPDFMKEARNTQEAISGDDIAVVSGLFVEQNVSKEEREPLLTWNRLESLVDNAQSLVNGVDAIKEAGIVWESLVSAVEAKKLVDVNENQTRKGKEELCPQFLSKMNATEADGSSLKLQIPCGLTQGSSITVIGIPDGLVGSFRIDLTGQPLPGEPDPPIIVHYNVRLLGDKSTEDPVIVQNSWTASQDWGAEERCPKFDPDMNKKVDDLDECNKMVGGEINRTSSTSLQSNTSRGVPVAREASKHEKYFPFKQGFLSVATLRVGTEGMQMTVDGKHITSFAFRDTLEPWLVSEIRITGDFRLISILASGLPTSEESEHVVDLEALKSPTLSPLRPLDLVIGVFSTANNFKRRMAVRRTWMQYDDVRSGRVAVRFFVGLHKSPLVNLELWNEARTYGDVQLMPFVDYYSLISWKTLAICIFGTEVDSAKFIMKTDDDAFVRVDEVLLSLSMTNNTRGLIYGLINSDSQPIRNPDSKWYISYEEWPEEKYPPWAHGPGYIVSRDIAESVGKLFKEGNLKMFKLEDVAMGIWIAELTKHGLEPHYENDGRIISDGCKDGYVVAHYQSPAEMTCLWRKYQETKRSLCCREW
Protein: AP complex subunit sigma (A0A2R8Q9P3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MMRFMLLFSRQGKLRLQKWYTATAERDKKKMVRELMQVLLDKYFGSVCELDIIFNFEKAYFILDEFLMGGEIQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA
Protein: Cyclin-dependent kinase 6 (EC 2.7.11.22) (CR2 protein kinase) (CRK2) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) (Q64261)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans (By similarity). May play a role in the centrosome organization during the cell cycle phases.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q00534}. Nucleus {ECO:0000250|UniProtKB:Q00534}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q00534}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q00534}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (By similarity). Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus. {ECO:0000250|UniProtKB:Q00534, ECO:0000269|PubMed:23918663}.
Interaction partners:
- Cyclin-dependent kinase 4 inhibitor B
- Cyclin-dependent kinase 4 inhibitor C
- Cyclin-dependent kinase 4 inhibitor D
- G1/S-specific cyclin-D2
- Cyclin-dependent kinase inhibitor 1B
- G1/S-specific cyclin-D1
- G1/S-specific cyclin-D3
- G1/S-specific cyclin-E1
- Cyclin-A2
- Cyclin-dependent kinase inhibitor 1
Sequence:
MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLNSHLPSNQSTSELNTA
Protein: Protein sey1 (EC 3.6.5.-) (Q9UTE0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03109, ECO:0000269|PubMed:14655046}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03109, ECO:0000269|PubMed:14655046}. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules. {ECO:0000255|HAMAP-Rule:MF_03109}.
Interaction partners:
- Protein yop1
- Reticulon-like protein 1
- Tetra-spanning protein 1
- Membrane glycoprotein spo14
- Syntaxin ufe1
Sequence:
MSTASNRVSTQIVDEHKQFNNELPKFMQSVGLLDAGFNYHVVAVLGSQSTGKSTLLNNLFGTSFSVMDASKRQQTTKGIWLSKANNSPILVMDVEGTDGRERGEDQDFERKSALFSISTSEVIIVNMWENQVGLYQGSNMALLKTVLEVNLQLFHNKKERCLLQFVIRDFLGNTSMENLADTIMTDLNNIWASLSKPEGFENSVINDFFDVGFTGLPHKILCSDAFSEAVDSLRERFVDNNNSDYIFNVSYHKKIPADGFSLYTREIWDTIENNKDLDLPTQQQLLAQYRCDEIITEVMEPFSTACTILQKEFLPGNLCKDLPTKLLNMFETVIEAYDRQASRYNVHIYQKKKQELIASVDSHLYVFFQAQLNALHKELIKSFFDASNEFPSDTPFKESSSIKINELVNKMREEGESLSLPHVHWDVDPFILKLSEELTQNSETLCKEKLKEKLEELFTGFEFEVSEAVEVAFQKLSHNVWDTLLNEFLAAQNTTIEKIKNIVPFYVDIDDTKTTEEYIINFKKNSWLFFRKKIDSEMSEVLLQQRLRVYFEELFRYDSDGMPKLWKKSGTIDRDYRESLTKTLDLINVLASIKVSDGNYPDLNVDIKTLEPEYTSPASFFTILNRRRVSDISVNFKRSADLIFMDCKRSVINTTTRIPPYFWVLLIVLGWNEFMAILRNPFVFMILMFGGTVVYGLYISGLIWPAKMVLERATNNLVDLATDRFSNTYQEQVQQRAMQRTEKSGSPVASADDAEAEKTALS
Protein: Ethylene-regulated transcript 2 (ERT2) (Ethylene-responsive nuclear protein / ethylene-regulated nuclear protein (ERT2)) (Putative ethylene-regulated transcript 2 ERT2) (Q9SUC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- CW14 protein
Sequence:
MPLPWKKSKSSRISRFVSDFQQSPKHGGSLVVETGFPTSLIDLFVKNRDRLKKQSSKRNNKNNKAQTETRVLSPPPPHMSLQRRMSLPSKLDPALVTEDSPLVRKIEETSVPEIIHEDDGGHRGGGGGGCVLIVVVFKVFMVAVLALSTKKLAVGITLSAFALLFLELAVARVFTYLNLCPDAQIRIDSLIDKLIGKRHKEKLEEEEESTSTHDRRNNVYFEIIEEPREEIRVTPQSDSSSLEKAKLVVDEKKEMQTIRDVMFKTEKSKSAKLKSKIVKKIVPKKLRSYKKKKKMKNKEKEEEEVELETEEEGSMTEVSSLYSDERIGSEISERDDLSSNPPFLESCTEVEEEEETGPKEDLTKVIGLIVIVLVGLLCGKVFAIGLTLSWCLILRVFCCKSQTSF
Protein: Myb-like protein B (Transcription factor Myb2) (O15816)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Transcriptional activator that initiates multicellular development by induction of adenylyl cyclase expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- EGF-like domain-containing protein
- Calcium-binding EF-hand domain-containing protein
- NAD-dependent deacetylase sir2C
Sequence:
MTAIFPNSNIPFYYWASTNAQPQQPQQSIQQQQQQQQQQQQQQQQQQQQQQHHHHQNIPPTPQPIFSPQLINKNFGCYGTSNQIPMIPQALFPQQTFNYSGLPLCPSPPNYNNYHTITNSPPHQIHSPQLTIDQHSPPTCVSGELSPTPLSSSTGFSNNNNNNNNNNNNNNNSNSNNNINNNNNNNIKRSYSAMMEENNYPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNINSSGSISSYSNNSCIEDDYSSDKHCSDKESSNDCDDDADSYFEEYEDDQEAIRVSITPFVNLICKTPGITIPIIKIFSECSKEEITVKQMLLKVSLFLKIIIKIKIKIKIKILIFYFLFFKKIKNLCLEFNLDNSIHNTLIHSLVKIDGDIKMVKYLIDNGISEQELEFTKDILLTSNSQEIIKKKRERKRESISRGIRSPPNKWTKEESQNLIKLVTENGDKQWKKIATKLGGGKTGAQCAQHWKRVLSPEIKKGSWDEAEEELLFQLVDKHGQSWKNVAIEIKTRTDIQCRYQYFKAIMSRQTEWNQLEDDILTKKIKLMTQNNEKISFQQVSKHLARAKTTKIPRTALECKSRWSQLNSTNVNNNNNNNNNSITTSSSNTNQQQQSTMVTPTSSPLSSPIPMSTPIINNSMPQQQVQQIQQQQISIQPYPQSFIQETQGFYRGNDQMQYHIQNQTIPQYHHQHNNNPLLML
Protein: Transmembrane protein (Q38AI2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRLTNTKPPPPRNAAFYITKLCTIAVCVYVLKMAKLAEVMLRSRKIIQPVMLLSYASFAIFVALWFYTGLVVKPKHPNWSETHKGLLHTAAGAWCAGGFLWAVAVWPVFHIWTIPLGLVSLVLFLNLVAIIPSFSRKEKE
Protein: ATP-dependent protease subunit HslV (EC 3.4.25.2) (Mitochondrial proteasome-like protease HslVU protease subunit) (Q383Q5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Protease subunit of a proteasome-like degradation complex. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins (By similarity). The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels.
Subcellular location: Mitochondrion matrix, kinetoplast {ECO:0000269|PubMed:18421378}. Note=Associated with kinetoplast DNA (kDNA).
Interaction partners:
- ATP-dependent protease ATPase subunit HslU1
- ATP-dependent protease ATPase subunit HslU2
- Katanin p60 ATPase-containing subunit A1
- Katanin p60 ATPase-containing subunit A1
Sequence:
MLRRVGRTTCSPAACQLRHTTILSVRKGDTVVLLGDRQVTLGERIVAKSSACKLRRINDDVVIGFAGSTADAISLMEKLENKIGEFPNQLTRAAVELAKEWRTDRALRRLEASLIVCSAEETLEIDGQGNVITPEADGIVAIGSGGTFAKAAARALIDVDGYDAEKIARKAMRIATDIDVFSNEHWDVEVLKRKSEKQEGSEASAKTSE
Protein: Inwardly rectifying potassium channel 2, isoform B (Q8IMY7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
Interaction partners:
Sequence:
MQVPLSDVQVLQDPTDAETLVGGDKEETFAHMKEWKRQYMRGISHTPSQAGVYYEALKGSSHSLAKGSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPETTFTMRQLSHNHSDQAS
Protein: Syntaxin-like protein psy1 (Q9USH7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:11739793}; Single-pass type IV membrane protein {ECO:0000269|PubMed:11739793}. Prospore membrane {ECO:0000269|PubMed:11739793}. Note=During vegetative growth located at the plasma membrane. As meiosis II is initiated located at the forespore membrane.
Interaction partners:
- Protein transport protein sec9
- Synaptobrevin homolog 1
- Protein transport protein sec1
- Probable vesicular-fusion protein sec17 homolog
- Protein transport protein sec22
- Vesicular-fusion protein sec18
- Synaptobrevin homolog ykt6
- Uncharacterized protein C1F3.03
- t-SNARE affecting a late Golgi compartment protein 2
- t-SNARE affecting a late Golgi compartment protein 1
Sequence:
MNKANDYTLGVEMIPLSMGEFFEEIDHIRDAIRQIEDNVGRIEMLHQQSLQEIDEANIAATTRHLEGYTSDTRRLQTSVQLAIRSLESQNMQLPPDNDTATRKTQTEAVKKKFMDQIRHFLQIEKTYRAQYEQRMRRQLEIANPRATEDDFQTAINEENGGQVFAQALLRSNRSGEARTALREVQERHADIKRIERTIAELAQLFQDMATMVQEQEPMVDKIVTDAVNVRTNMGEGTQHMDRAIKSARAARKKKWICFGICVVIICVIVAVLCGVLIPVLGNRH
Protein: Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (mBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Q9Z1Q2)
Organism: Mus musculus (Mouse)
Function: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G).
Subcellular location: Membrane {ECO:0000305|PubMed:25580854}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lysophosphatidylserine lipase ABHD12
- Monoacylglycerol lipase ABHD6
- Phospholipase ABHD3
- Protein PRRC2A
Sequence:
MAKLLSCVLGPRLYKIYRERDTDRAASSVPETPTAVPAASSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSAENKRQLANYNFDFRSWPVDFHWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTFLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIVIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMPDSWRALVTRTVRQHLNLNNSEQLCRFQGPVLLVRRTKDEIITTTVPEDIMSNRGNDLLLKLLQFRYPRVMVEEGLRAVRQWLEASSQLEEASIYSRWEVEEDWCVSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQHFQMPWHL
Protein: Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) (P53026)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62906}.
Interaction partners:
- Large ribosomal subunit protein eL15
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS8
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS19
Sequence:
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDERKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY
Protein: Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (Q9CUU3)
Organism: Mus musculus (Mouse)
Function: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.
Subcellular location: Nucleus {ECO:0000269|PubMed:16717126}. Chromosome {ECO:0000269|PubMed:16717126, ECO:0000269|PubMed:22346761}. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes. {ECO:0000269|PubMed:16717126}.
Interaction partners:
- Synaptonemal complex protein 3
- Synaptonemal complex protein 1
- Testis-expressed protein 12
- Synaptonemal complex central element protein 2
- Synaptonemal complex central element protein 3
- Testis-expressed protein 11
- Synaptonemal complex central element protein 1
- Structural maintenance of chromosomes protein 1B
- Cohesin subunit SA-3
- HORMA domain-containing protein 1
Sequence:
MPVRPDLQQLEKCIDDALRKNDFKPLLALLQIDICEDVKIKCSKQFLRKLDDLICRELNKKDIQTVSSILISIGRCSKNIFILGQAGLQTMIKQGLVQKMVSWFENSKEIILNQQQSKDEAVMNMIEDLFDLLMVIYDISDEGKNQVLESFIPQICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILSNQEMLTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKEIKDCEFETDCRIFLNLVNGILGDKRRVYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDEEDHQWEAVTVPEEKVQMYNIEVRESKKLLTLTLKNIVKISKKEGKELLFYFDESLEITNVTKKVFGGNKYKEFTRKQGISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSDIQKKLVNPLELGNSSSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSREPLQAINSVEKAVSKTSESGMDYAASPKSRQSDGRKRWNNRANHNKTTAVIQNKQYEDNESPDQNFNEIEDTLSNVSSAVGKVDKPVLPGVLDISKNTTHSRWACWTPVTTIKLCNNQRSRALPGDTCTQDTGVNKKCTKQKSVSDDDSEETQKGKYSKDVIKCNKSDEAEFCERNIQEQNHPKYSQKKNTANAKKSDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSKRNHTKSRKELMSELTSCELEEIPVRENSKGKRFTGASESLINQISRRYNPSDSMMSTRKLKEPQDGSGFSKKPDLQFNKVQRKSYRKLKATVVNVTSECPLDDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSLKLVKNHDEHDPFLKTKDKRMLSYEKKTLLSDTETECGCDDSKTDISWLKEPKTKRLMDYSRNKNTTKYKSRKSRSSMEKGQPRPTMVLNKNSMKNDYEVVVDGRTRLPRRATKTKKNYKDLSTSESESESEKECSYLFKDKLPTKEETIHSRAQTKKLPEKQQKVFNSEALKGQPSEEQKNSSRLREGREDSLCLSSASVSRSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAPSPEFLNGNNSVVGRGQSPRISETSAMCVRKSYSPASGPPFSPRHTPTKNNSVVNMKKANSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPESCDNHMQNKREGNHAASPLSLSSEKIEKMWFDMPSENTHVSGPSQRGSKRRMYLEDDELSNSNEAEVEEAEEREHLLSKKRCQWENSDQHTFKTSLSTPDFSVPKDWQQELQGAGMFYDNISSDYKRKTDSQHKIMDDFTTKTLKLTQQHLMAMTSQAQGRRDENVEKFQVTLLDELEKVEKDSQTLRDLEKELVDIEEKLVQKMRAYHRCERERFRVLKTSLDKSFLVYNSVYEESVFTSEMCLMKANMKMLQDKLLKEMHEEEVLNIRRGLQSLFKAHEGNDA
Protein: UV excision repair protein RAD23 (Q9XZE0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367049}. Cytoplasm {ECO:0000256|RuleBase:RU367049}.
Interaction partners:
Sequence:
MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEERGPEYVAEKQKLIYAGVILTDDRTVGSYNVDEKKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHTNSPSSTNTEDSVLSRETRPLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEMGYPREQVERAMAASYNNPERAVEYLINGIPAEEGTFYNRLNESTNPSLIPSGPQPASATSAERSTESNSDPFEFLRSQPQFLQMRSLIYQNPHLLHAVLQQIGQTNPALLQLISENQDAFLNMLNQPIDRESESGATVPPVSNARIPSTLDNVDLFSPDLEVATSAQRSAAGTSAAHQSGSAADNEDLEQPLGVSTIRLNRQDKDAIERLKALGFPEALVLQAYFACEKNEEQAANFLLSSSFED
Protein: inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) (B7Z0Q1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESAQEDASSTDVFLVTANVGSLFEDPERLLQLWLSEFLAKIAVAQPRFLALHLQEVGGKTYEKSMEYVQEFIRCLCDAPEMGDFTCVHIFMDEDFKSAEHFTALGSLYFVHKDVASLKIWNFLTHSWEESLQDVKDKHIYSGNIETIATKEKSKFPQHFFPECKWSRKGFMRTRWEINGTVIDLVNIHLFHDASNLAACENFPSVYCKTRRRALVHTIERFHLDEQNGTVPFFLFGDFNFRCDTEGVVKELTENLTPHRVQNVKNENDKIHYRNSTGNNVLTVGKKEFSHADHQLKFKEDWLKKFDRELEPLKDVLVEYPIKFVPSYPFEEDPEMPTDYMSTRCPAWCDRILMSPQVNEIIQSDDWTYGMIGEAVCMGDHKPVYLTVRLKPNKGPADPTAISKLPESLANLVNQALNDESLWMEQSVVDDSSASNSSAAKSRYILMKKGTTSPCKEDTDEAGALAAKSDGLDTESAMLLKETTV