wanglab/gogpt-training-data huggingface dataset:
Protein: AP2 domain transcription factor AP2-SP2, putative (Q8I1Y8)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMNKEKYVDILKEDKPSTLYIEKNIIKNNHVILNKDRNIIKTVDNNFEYKNECYQKDYKNDIIDKGNVYDKYINNNNNNNEGTKKNCLRYDRFHIYDDKIKNIDDINETIKMKEEKIIIPLHTFDEKKTNNMDLKISNNDIYNNMNPCNDNIKNDILEVNIEKEKRNVMNEKGNNFVNNKMGIDNIEGEHKDGIISPNNYIKLKNINENDKINNNDRINNNDKINNNDNINNKKKSSKRTGIPLNERKYYRILAKQMKKIQGLTFDHNQIRWIAYWKNENNKQIQKHFPVCKFGFHEARQLALEFRNLKINDKNKNSNQKNKNINNNNNMNNNNVNNNNVNNNNVNNNNGNYIKKKDKNKKYVINIKNQYNNNGKQYINHYPQNININHMNFNMNNLNMDYTHNNNNNNNMFNGLHNNSLSKLKLCNNIEDIYCNEVKLQEPYRINILSRNMENKENDIYIYEHNIGKHFDNNNNNDNYSNYVHSYGLHNNLYNHAEKKEILNNMIYNIEGVNNNYIGYDTQDMENNYLQNYDFGKIDLNNSFDNINYMYENGKYNSTYVQDIHNNNHNNNNIMVHNMYANDDLVKGNYDGNTNYCNMDNDKKITNEHSIVYNNNNCYYYYNYVLPYTLNLDKKYINNYNFPYSYNTMKNDPNIESADDARTFPYVSSYEKSKIPIYYEMNTNNKNDKKIDYDDDDDDDNNNNNISCTYGTHQNLLHNYNNNNMDEPIEEENTYYDKEYKNKTENTNLLKNIKVNNIMNVNNNNEHIKINLYSNKKNEKDLLTYTLTRTSTSSHLSEHLNIFIKNNQNVSLEKDSTKSNIFRKDEKFFLVTKDNSHISKKMDIHNDKSNQKNKNTKNKNKNKKKKKKKKKKIIKSCTDEINKKNIENHVKSNDSIVKCENTKYHKIESNNLTHINHQKEDEKNISKLDSIKNIHSYEKCMQNKLYKSNYYTQNLQCEKNDMCTNLFSKKWIQYNDEEHKNETDLIEIEKNKEGILYNVNVYNNKNICNNKNICNNTNICNNKNICNNQNICNNKNICNNKNIYNYDNARKDGHMINMSSQNKLSKEKALKTCDFTLINKNDDTHNNDINNIHNKCDMDHLYNHIIPYKNIKITEEYKSNKKNDTNHNKYTNKKKISKEKKTNNVSYKFNDVKENDKDQGDITNFYHEMMRIPKMKGVHFDARQKRWCAYGYKKKECFSVYRYGFLIARELAIRSRLKVQKRKNNLRIRKMNTRENEKKKEKQNNLTFNNISQRKNNYWNKISDENHKKKKTNHIINDNLIYNKYDNKTEEINSYEKEVINNKMYHNNMYDEHNKINIYYNEKNINENFNYITDNNKDIYNNNNNNNNNNNNNNNYCNVYEDSYNNYNNMMIIQNKTDKNDTKHTSCHIPRNIEQHLYYNDDQNINDYKCNNNMNNMNNNREQYCNNREQYCNNREQYCNNREQYCNNREQYCNNREQYCNNREQYCNNREQYCNNREQYCNNREQYCNNPEQYYNNHEQYCNNPEQYCNNPEQYCNNPEQYCNNPEQYYNNHEQYCNNPEQYYKNNNIQQSNHSYNINNNTINCKTNPEEENMLVNINNEFNNKLPNFYTDTNLINSKETNKNLHGINDLNNENKKFFFLNNINNYHSKDIMDNYKQTDNINEEDIKNITPVNKNNINNIICMTNEKENMSNHTKEYKIKNIDYNDNIYVSDSLNEYYNNNKNIEEINNKKNNHIYTSSNQIYNCIYNIDKDEYNNQNVISIYNNFYNIQENINENHSKKKKKISVNNVNINYINDQNYGNMYYNEFNSSILFSIPPDDMYVARQNVDTEKKKKKVFYIIPPKINNNEENTFNGNMIYVDEYNNEIIQNGDDNNNIHNNNNNIYIHNNNINNNYNNIYIHNNCDNDNVMEKISNIQYDNTYKLNEEIKEDEKNIYLYLSNHPYDNLKKDYHINEQKCLDNTNNQTDDNFYNVYLWNEIKKKDEPFQDNLTNENLSDELFFLKNKNYSVEKYREDVINNKGKHETHFTSNNYNTKNKDNHFINNSYKNTKDSIHLYNLNQVKKEKLYTIHDTKNLVLRKINILKEFDHKFLSPGMVNINIHDEDIKKNKHYNFVYEEIIHKYCLSIFKKINISTFFKDNEKRIFLMENYWEYSILTLHDFNVNMVHDMPARLNLRKIIYKYLILELFTNAQSCNFLTCIEKGTTFLISHINKDMEKEIFQKKSRKYINLMKKVQIYHLNMIDNIYDLKAIQLYTNILINCLIQNTTSSNLSFKEQEMLLRSLLFFYFKKKFI
Protein: Small ribosomal subunit protein mS81 (rPPR8) (Pentatricopeptide repeat-containing protein At5g15980, mitochondrial) (Q8LPF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000303|PubMed:36423343, ECO:0000305}.
Interaction partners:
- SAUR-like auxin-responsive protein family
- Probable E3 ubiquitin-protein ligase LUL1
- C2H2-like zinc finger protein
- C3HC4-type RING finger protein
- C3HC4-type RING finger protein
- L-type lectin-domain containing receptor kinase IX.2
- Protein SMALL AUXIN UP-REGULATED RNA 51
- Dof zinc finger protein DOF5.7
- RING-type E3 ubiquitin transferase
Sequence:
MRYQQWRLMLLRSYHRSHLPYLSPCSQVTSISSRSFSSFIHPGIGALQQSEQLCPLRSPMTSSGNLVKSVGRSFSSEPAVEEKSSAEATVIDIFSRLSGEDEIRKELESSGVVISQDLALKVLRKLESNPDVAKSFFQWIKEASPEELSSKNYNMMLRILGGNGLVDEFWGLVDVMKKKGHGLSANVRDKVGDKFQKDGLESDLLRLRKLFTSDCLDNSAENVCDRVCKIVMKEEWGDDVEKRVRDLNVEFKSDLVKMIVERLDVEPRKALLFFRWIDESDLFKHDEKTYNAMARVLGKEKFLDRFQNIVVEMRSAGYEVEIETYVRVSTRFCQTKLIKEAVDLFEIAMAGSSSSNNPTPHCFCLLLKKIVTAKILDMDLFSRAVKVYTKNGNALTDSLLKSVLKSLRSVDRVEQSNELLKEMKRGGYVPSGDMQSMIASSLSRKGKKDEADEFVDFMESSGNNLDDKAMASLVEGYCDSGNLDEALVCFEKMVGNTGVSYADYSFEKLVLAYCNKNQVRDAYKLLSAQVTKNQLKPRHSTYKSLVTNLLTKKIARDGGFEEALSLLPIMKDHGFPPFIDPFMSYFSSTGKSTEALGFLKAMTSNNFPYISVVLRVFETMMKSARHSEAQDLLSLCPNYIRNNPDVLELFNTMKPNESAVEKPLAASA
Protein: Ribonucleoside-diphosphate reductase large chain 1 (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit 1) (Ribonucleotide reductase large subunit 1) (P21524)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12732713}.
Interaction partners:
- Ribonucleoside-diphosphate reductase small chain 2
- Ribonucleoside-diphosphate reductase small chain 1
- Ribonucleoside-diphosphate reductase large chain 2
- Ribonucleotide reductase inhibitor protein SML1
- DNA damage response protein kinase DUN1
- Thymidylate kinase
- Nucleoside diphosphate kinase
- Guanylate kinase
- Adenylate kinase isoenzyme 6 homolog FAP7
- Serine/threonine-protein kinase RAD53
Sequence:
MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQKIADQATENVADISNLKRPSYMPSSASYAASDFVPAAVTANATIPSLDSSSEASREASPAPTGSHSLTKGMAELNVQESKVEVPEVPAPTKNEEKAAPIVDDEETEFDIYNSKVIACAIDNPEACEMCSG
Protein: Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4) (Q9JJN6)
Organism: Mus musculus (Mouse)
Function: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Catenin beta-1
- Adenomatous polyposis coli protein
- Glycogen synthase kinase-3 beta
- Adenomatous polyposis coli protein 2
- Axin-1
- Calcyclin-binding protein
- Dapper homolog 1
- E3 ubiquitin-protein ligase SIAH1A
- E3 ubiquitin-protein ligase SIAH1B
- Histone deacetylase 5
Sequence:
MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVSSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ
Protein: GTP-binding protein YPT11 (Rab GTPase YPT11) (P48559)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the positive control of both endoplasmic reticulum (ER) and mitochondrion inheritance during cell divison. Required for the MYO2-dependent retention of newly inherited mitochondria at the bud tip in developing daughter cells.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16980630}; Lipid-anchor {ECO:0000269|PubMed:16980630}; Cytoplasmic side {ECO:0000269|PubMed:16980630}. Bud tip {ECO:0000269|PubMed:16980630}. Bud neck {ECO:0000269|PubMed:16980630}. Note=Enriched in the peripheral ER of small buds and daughter cells. Concentrates at the site of bud emergence, at the bud tip of the growing bud, and at the bud neck during M phase. Interaction with MYO2 is required for proper localization to the bud.
Interaction partners:
- Vacuolar morphogenesis protein 6
- E3 ubiquitin-protein ligase PEP5
- Myosin-2
- Mitochondrial MYO2 receptor-related protein 1
- vacuole-related protein 17
- Inheritance of peroxisomes protein 2
- Phosphatidylinositol 4-kinase PIK1
- Vacuolar protein 8
- Rab guanine nucleotide exchange factor SEC2
- Protein BIM1
Sequence:
MSQRKRYSLNVVTSPSIPSPTPSAPIRTNESNWEAASPASAASSFLPNVHHGGTVLNPGLGIMRSPSLNKSGAFGRSGSSGSSTVIEPSNIKLLLIGDANVGKTAMILSYCRELLTRAEMSRSARLRHQQQQQHKDLGLKKTVVNHRLSMKEKRKRYSSNDFEKEFKDINHFADETSDFGNPNIGDDNNHEMADPNEIVIETRSTIGIDIKTNLVNIDNRFFNVILWDTAGQERYQNAIIPSLYKKTNAVILTYDITNAKSFQSCMERWIVQALENFSSQDLLKARFFLVGNKIDLYKERQVTHYDVVQMVQEMQLKHGIKISGNFEVSCKWVNVVERTMNMIILDLVENGCFENNDPCVSITTSDDVQGHEQEFHDTVEEPFNFTRQRQHQLEKNNTVDITKPNDDIANNQSICCV
Protein: Tuberous sclerosis 2 protein homolog (Q9UUG9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Together with tsc1, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Tuberous sclerosis 1 protein homolog
- GTP-binding protein rhb1
- Serine/threonine-protein kinase tor2
- Serine/threonine-protein kinase tor1
- Serine/threonine-protein kinase sck2
- Serine/threonine-protein kinase sck1
- Serine/threonine-protein kinase gad8
- G1/S-specific cyclin pas1
- GTP-binding protein gtr1
- Nitrogen permease regulator 3-like protein
Sequence:
MNNKSLLDLSSEPAIKDTDILSYFDANLPFKKRHQIVRSIYHGLKYYIYSSTSIIQVWQNIQDFISTKNDNAAFRELVYNLMMRYVSTQKHLSIIERHTFFQTIEKDPFQDIAELQLRLKSLSVLTDEGHKISGIENRVGPLLSAWFNQYLQWQSQATELQGKDADSKLVHLLFFKSLFKFSTNLVKFQWFLVPEPQMLQLVNSVVQICNHARLEDVVTEVLMFFDSMIRYSVIPKASLYDTVLILCSTYISTYSYSKLAQSVIFNLISSPVSNLAFENVFNILQYNRSNVNAVRGAVRLMRFLMLQEVKNDAIASITLSSSIEFTEFPLGFNENVDFEILGTVYLFLRTPSILNRLNFLDWHRILNILMYCSQYLPLKASTSKEAFSKTAAFANIYDRVLDFLDFEALIPLLQQFQVKLVFFLKDVLPVLKPKIRKKLLRLFETYNLIFPCNQYWVFNLEFLLGIYQCKTFDLEDRALLFKLVEDACSVADENSAPILCSKFLFPVIESFSKESDDCVVSPVYNMLFFLSVNFQNPGLKDCIDHIFQQLISDTSSVTVRRLATSTLIRLFYYYYDLRDAVPIQETLAKMLEILETPSFPFVSRMLCLQFFLRFRANGTSIYICENIDLNEPFKVLNVDSELIPAVYPISDSFVNSATVEKHIWERKENDLIKISNHSTEYGKDFVTFPTSSLLRFYRKSMATESNWTILMFMITHLADQISNRSMFIGALEEIYNLLDFMCDIVFERVSISAEIPSNIRKANIMIPILQNVQMLFVYHDQFSRAQEDELVSVFFAGLQKWNEACHVSIHSLMLCCYELPVSIRKQLPAILVTLSRLITKPDLSVHILEFLCSLARLPDLIANFTDADYRQIFAIALKYIQHRDFTKESKDSNDTESILKNSYSSYVLALAYSVLQIWFLSLRLTERKKFVPWILRGLKLASEGKPLEDLCLVQYDMMQQFCYSNSDINNQTSTFVDSDVESETWIRGNSLFTINVSVNSGFLEAVIRRPTGTTQYTFRNEASLQKFLWEENLTSSKALTRGLLCTPSSFVSHFLDPHGISLYNQPLLLPSNDDSVRRAISVFDRIPVIESLKAGLVYVGYQQRREADILANTNPSEDFLTFLNGLGTLFELKTDQKVFAGGLDRENDIDGAFAYCWKDKVTQMVFHCTTMMPTNIEHDPGCTLKKRHIGNDFVTIIFNESGLEYDFDTIPSQFNFVNIVITPESESIRRTGRQIKFYKVKALTKYDIDFSLFRRYKIVSSDALPAIVRDVTLNAAVFSHIYHRSAGDYVHIWAERLRQLKRLREKFQASVLPEDYNLDEQTKTKLQNGTNFSDFTSYL
Protein: Outer membrane protein A (Outer membrane porin A) (Q8ZG77)
Organism: Yersinia pestis
Function: With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
Subcellular location: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00842}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00842}.
Interaction partners:
- Similar to Escherichia coli outer membrane protein C precursor OmpC or MeoA or Par SW:OMPC_ECOLI
- Similar to Klebsiella pneumoniae outer membrane protein C OmpC SW:OMPC_KLEPN
- Chaperone protein Skp
- Similar to Salmonella typhi outer membrane protein C precursor OmpC SW:OMPC_SALTI
- Outer membrane protein assembly factor BamA
- Protein translocase subunit SecA
- Large ribosomal subunit protein bL25
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein bS6
Sequence:
MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAGAFFGYQANQYLGFEMGYDWLGRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLGGLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTKNWATRMEYQWVNNIGDRETVGARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPEGQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPADKITARGEGQANPVTGNTCDNVKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA
Protein: Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) (P01589)
Organism: Homo sapiens (Human)
Function: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Interleukin-2
- Cytokine receptor common subunit gamma
- Interleukin-2 receptor subunit beta
- Tyrosine-protein kinase JAK3
- Signal transducer and activator of transcription 5A
- Signal transducer and activator of transcription 5B
- Interleukin-15
- Interleukin-4
- Tyrosine-protein kinase JAK1
- Interleukin-7
Sequence:
MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI
Protein: Y' element ATP-dependent helicase protein 1 copy 4 (EC 3.6.4.12) (O13559)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- Putative uncharacterized protein YLR462W
- Putative uncharacterized protein YLR463C
- Putative uncharacterized protein BSC3
- Y' element ATP-dependent helicase YIL177C
- Y' element ATP-dependent helicase protein 1 copy 6
- Uncharacterized protein YHL050C
- Putative uncharacterized protein YLR466C-B
- GTP-binding protein YPT1
- Uncharacterized protein YEL075C
Sequence:
MWKTLGRVEQLLPYASLILRNREVLFREPKRGIDEYLENDSFFQMIPVKYREIVLPKLRRDTNKMTAALKNKVAVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGRKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIIALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSAITTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
Protein: Argonaute-1, isoform A (Argonaute-1, isoform C) (Argonaute-1, isoform D) (LP02696p) (SD07283p) (Q32KD4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein Gawky
- Endoribonuclease Dcr-1
- Endoribonuclease Dcr-2
- Ribonuclease 3
- Protein Loquacious
- LD06392p
- LD23072p
- Fragile X messenger ribonucleoprotein 1 homolog
- LD26789p
- Protein argonaute-2
Sequence:
MSTERELAPGGPAQLHPHTLPLTFPDLQMTSTVGIIGKVYESQWTPSPTRPQSPSQAQTSFDTLTSPPAPGSSVNPTAVTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA
Protein: Haptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] (Q61646)
Organism: Mus musculus (Mouse)
Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Scavenger receptor cysteine-rich type 1 protein M130
- Apolipoprotein A-I
- Hemopexin
- Hemoglobin subunit alpha
- Albumin
- Beta-2-glycoprotein 1
- Hemoglobin subunit beta-1
- Serum paraoxonase/arylesterase 1
- Alpha-1-acid glycoprotein 1
- Apolipoprotein C-I
Sequence:
MRALGAVVTLLLWGQLFAVELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDITPTLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYIAPGRVGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSPVGVQPILNEHTFCAGLTKYQEDTCYGDAGSAFAIHDMEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN
Protein: Ras-related protein Rab-13 (EC 3.6.5.2) (P35286)
Organism: Rattus norvegicus (Rat)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, tight junction {ECO:0000250|UniProtKB:P51153}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P51153}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51153}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9DD03}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (By similarity). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250|UniProtKB:P51153, ECO:0000250|UniProtKB:Q9DD03}.
Interaction partners:
- MICAL-like protein 2
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Rab GDP dissociation inhibitor beta
- Rab GDP dissociation inhibitor alpha
- Tight junction protein ZO-1
- DENN domain containing 2B
- DENN domain containing 1C
- Rab-3A-interacting protein
- MICAL-like protein 1
Sequence:
MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNSTYISTIGIDFKIRTVEIEGKRIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQREQAERLAREHRIRFFETSAKSSVNVDEAFSSLARDILLKTGGRRSGNSSKPSSTDLKVSDKKNSNKCSLG
Protein: Glutamate-rich protein 3 (Q5RHP9)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:31712586}. Cytoplasm {ECO:0000269|PubMed:33230203}. Note=Located in primary cilia, with enriched localization along the entire ciliary axoneme (PubMed:31712586). Localized to the cytoplasm in neurons and appears to be vesicle-associated (PubMed:33230203). {ECO:0000269|PubMed:31712586, ECO:0000269|PubMed:33230203}.
Interaction partners:
- Tetraspanin-5
Sequence:
MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRDHQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPILSPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPKVTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPPTGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHLSSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVNRLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETADVSPNNVQV
Protein: Elongation factor Ts (EF-Ts) (P9WNM1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Elongation factor Tu
- Small ribosomal subunit protein uS2
- ATP synthase subunit b-delta
- Small ribosomal subunit protein uS9
- Ribosome-recycling factor
- Large ribosomal subunit protein bL12
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL2
Sequence:
MANFTAADVKRLRELTGAGMLACKNALAETDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAKDGALIELNCETDFVAKNAEFQTLADQVVAAAAAAKPADVDALKGASIGDKTVEQAIAELSAKIGEKLELRRVAIFDGTVEAYLHRRSADLPPAVGVLVEYRGDDAAAAHAVALQIAALRARYLSRDDVPEDIVASERRIAEETARAEGKPEQALPKIVEGRLNGFFKDAVLLEQASVSDNKKTVKALLDVAGVTVTRFVRFEVGQA
Protein: Deoxyhypusine hydroxylase (DOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (Q59Z14)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03101}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03101}.
Interaction partners:
- Eukaryotic translation initiation factor 5A
- Deoxyhypusine synthase
- Elf1p
- Ribosome biosynthesis protein
- Elongation factor 3
- malate dehydrogenase
Sequence:
MSADEVNIDTASLEELRDILINKTGNTKLANRFRALFNLKSVGSEDSDKERAHKAIKYIAECFNDDSELLKHEVAYVLGQTKDLYAAPYLREVLENDNQQCMVRHEAAEALGALGDKESLPLLEKYFKEDPLLEIRQTCELAIERIHWENSEKAKNEVLEKSLYTSIDPAPPLATNDSTSKVEKLKEILNDQDKPLFERYRAMFRLRDIGTDEACLALASGFDDPSALFKHEIAYVFGQMCNPVTVPSLIKVLKDESEAGMVRHEAAEALGSIATDECLPVLQSFLNDSEPVVRDSAIVALDMYEYENSNELEYATVK