wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1) (O60721)
Organism: Homo sapiens (Human)
Function: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel alpha-1
- Calcium-binding protein 4
Sequence:
MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPSKPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPRGEMKSYSPTQVREKVKYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLKRIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPATSEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVKPTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
Protein: Bacterial microcompartment shell protein EutS (Ethanolamine utilization protein EutS) (Q9ZFV7)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: A probably major component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation. Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC; expression of this protein alone can also form BMCs (which may be less tightly closed than eutSMNLK shells). The 'bent' shape of this subunit is required for integration of cargo proteins into these BMCs. Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo. Targets at least 2 proteins (EutC and EutE) to the interior of the BMC. Proteins such as EutS containing circularly permuted BMC domains may play a key role in conferring heterogeneity and flexibility in this BMC (Probable).
Subcellular location: Bacterial microcompartment {ECO:0000269|PubMed:22428024, ECO:0000269|PubMed:27063436, ECO:0000269|PubMed:27450681}.
Interaction partners:
- Probable acetate kinase EutP
- Bacterial microcompartment shell protein EutL
- Bacterial microcompartment shell protein EutM
- Acetate kinase EutQ
- Bacterial microcompartment shell protein EutK
- Bacterial microcompartment shell vertex protein EutN
- Corrinoid adenosyltransferase EutT
- Ethanolamine ammonia-lyase reactivase EutA
- Ethanolamine ammonia-lyase small subunit
- Ethanolamine utilization protein EutJ
Sequence:
MNKERIIQEFVPGKQVTLAHLIAHPGEELAKKIGVPDAGAIGIMTLTPGETAMIAGDLAMKAADVHIGFLDRFSGALVIYGTVGAVEEALLQTVSGLGRLLNFTLCELTKS
Protein: Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) (O35144)
Organism: Mus musculus (Mouse)
Function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:20339076}. Chromosome, telomere {ECO:0000269|PubMed:20339076}. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase. {ECO:0000269|PubMed:20339076}.
Interaction partners:
- TERF1-interacting nuclear factor 2
- Telomeric repeat-binding factor 2-interacting protein 1
- Telomeric repeat-binding factor 1
- Protection of telomeres protein 1
- Protection of telomeres protein 1
- Adrenocortical dysplasia protein
- 5' exonuclease Apollo
- Tripeptidyl-peptidase 1
- Structure-specific endonuclease subunit SLX4
- Nibrin
Sequence:
MAAGAGTAGPASGPGVVRDPMASQPRKRPSREGGEGGEGERRSNTMAGGGGSSDSSGRAASRRASRSGGRARRGRHEPGLGGAAERGAGEARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEKASKILKKYMSKDPTTQKLRTDLLNIIREKNLAHPVIQNFSYEVFQQKMLRFLESHLDDTEPYLLTMAKKALKSESAASSTMREEKHPEPVEKPLREPPSRQPQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVLANLASPSSPAHKHKRPRKDEHESAAPAEGEGGSDRQPRNSPMTISRLLLEEDSQSTEPSPGLNSSHKAMSASKPRALNQPHPGEKKPKASKDKWNSPNGLEEKEVWLEEDQLFEVQAPGEDRSSSLTRKQKWTIEESEWVKDGVRKYGEGNWAAISKSYPFVNRTAVMIKDRWRTMKKLGMN
Protein: EMP1-trafficking protein (Q8I669)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MVNKDNRKIHKAHISRYVGYRKREMNNTFFSKSYKLFFSNNKYEYSKDEEKKNIYPLSLKLLILTVFICILQFSNNNGYFEKYVNKNSGNDNEYYFNIKYNRSLAELKKRIGAIREMINNDSFGTVFKNHLPLPASITKGDSEAEAGGNDSRNTSEKAVSSSNDDNNTNDEGKDKRKLKGICKVKKLMGLSKICGNKSGKSNLQLQKALDILEIIFEQVSKALPFILPFVPPFMVYKYGYAKTYVMLYTFNLIHAMFKWAILLRNMLMKSKQRRNEALREQDDNLNIQNQ
Protein: REST corepressor (CoREST) (Q59E36)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:15306652}.
Interaction partners:
Sequence:
MVLAERNTTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKIQKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKPELAAAVLKIGVAEAADAVATVASSTASGVIGAATSASKPSTSATITIIDESDTATNSSSDVVTTGLATSTGSSALSSTTSAPASKTQTSSEELSAQKSNPASGIAAIGAATGGGQTANSSGSKRDSSVLPVAEQPPAKKIALSTGGGSSVAEFLAN
Protein: Mitochondrial thiamine pyrophosphate carrier 1 (Q5A1Z2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
Sequence:
MSSDLEQTNNPPMRGIPAITGPIDYTKAFHVFPKELQPFRNSIIAYGASLFSTLVGFPLDTVKTRMQTHKNFTSYFDCVKKTYAKEGVRGFFRGIWAPIISTSLSKSLSVSLFTTVKPYTYGLLYETPWTKNIESSHPFLRNIPVCFISGLIAGGGVSLFACPFEFTKVYAQLEKLVASKSLKELSNLNNNGGTSSAQLTTKFNSVKTPSTAVIVKEILKYEGIKGLYSGYKYHLMRDSISTGFYYSIYESMKWSINNFINKDPSISSPFSVLLAGGMSGVFSWVLIFPIDTTKSMVQKDAVTNILRRSHGLEPLPPKHRKLQKFEKRAYRGLGISVTRSFIVNMVFFGVFELGMTYLA
Protein: 3-hydroxyacyl-thioester dehydratase X (EC 4.2.1.-) (3-hydroxybutyryl-CoA dehydratase) (EC 4.2.1.55) (Enoyl-CoA hydratase 2) (EC 4.2.1.119) (O53664)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. Displays a broad chain length specificity, with a predilection for the C8 to C12 substrates.
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] reductase
- Probable acetyl-CoA acyltransferase FadA2
- 3-hydroxyacyl-thioester dehydratase Y
- Probable fatty oxidation protein FadB
Sequence:
MTQPSGLKNLLRAAAGALPVVPRTDQLPNRTVTVEELPIDPANVAAYAAVTGLRYGNQVPLTYPFALTFPSVMSLVTGFDFPFAAMGAIHTENHITQYRPIAVTDAVGVRVRAENLREHRRGLLVDLVTNVSVGNDVAWHQVTTFLHQQRTSLSGEPKPPPQKKPKLPPPAAVLRITPAKIRRYAAVGGDHNPIHTNPIAAKLFGFPTVIAHGMFTAAAVLANIEARFPDAVRYSVRFAKPVLLPATAGLYVAEGDGGWDLTLRNMAKGYPHLTATVRGL
Protein: G2/mitotic-specific cyclin-2 (P24869)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Interaction partners:
- Cyclin-dependent kinase 1
- Tyrosine-protein phosphatase CDC14
- Securin
- Protein SIC1
- Cell division control protein 15
- Mitosis inhibitor protein kinase SWE1
- Cyclin-dependent kinases regulatory subunit
- G2/mitotic-specific cyclin-1
- Sporulation-specific protein 12
- Cell cycle protein kinase DBF2
Sequence:
MSNPIENTENSQNTSSSRFLRNVQRLALNNVTNTTFQKSNANNPALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTLKENGIQLPKNNLLDDKENQDPSSQQFGALTSIKEGRAELPANISLQESSSAKEIIQHDPLKGVGSSTEVVHNSVENEKLHPARSQLQVRNTESETDSGKKRPISTIVEQELPKKFKVCDENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYLVSPIVHDEFHRKYQSRRFMKASIISVQWALKVRKNGYDIMTLHE
Protein: AT5G07890 protein (Myosin heavy chain-like protein) (B9DG86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Vesicle-fusing ATPase
- Protein transport Sec1b
- Alpha-soluble NSF attachment protein 2
- Alpha-soluble NSF attachment protein 1
- Protein transport Sec1a
- SNARE-interacting protein KEULE
- Conserved oligomeric Golgi complex subunit 6
Sequence:
MSSSSGSFSGSSSSACSSRSDCENSFDVEDLLQIGTTRRELRKQKDLLRESQPHSIELVRRLELHTKSLSESRLEDTARIQMMEKELLNCYKEIDYLRDQLIFRSKEVNYLNEHLHDLEFKLAESRNLEEEVNSLRDELCMSKSEHLLLLQELESKEIELQCSSLTLEKLEETISSLTLESLCEIESMKLDITALEQALFDAMKIQEESIQEKDQLKGIIEESQFQSQRAKENVKYIEKQNEDLREKFTASEKSIKDFFQSTKERLESEDEQPLNAMCFFAELSHVLPVSNEVRNCFDAIMKKLELSQNVNLIDKVEGMGKQIHQHEDVVKQLKEELKQEKLKAKEEAEDLTQEMAELRYKMTCLLDEERNRRVCIEQASLQRISELEAQIKRDVKKPASNEMLPLPGL
Protein: Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl leukotrienase) (GGL) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain] (Q9Z2A9)
Organism: Mus musculus (Mouse)
Function: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate (By similarity). Converts leukotriene C4 (LTC4), a glutathione-S-conjugate, to leukotriene D4 (LTD4). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine. May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:12163373}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163373}.
Interaction partners:
- Glutathione hydrolase 6
- Glutathione hydrolase 7
- 5-oxoprolinase
- Glutathione synthetase
- Leukotriene C4 synthase
- Gamma-glutamylcyclotransferase
- Glutathione reductase, mitochondrial
- Glutamate--cysteine ligase catalytic subunit
- Cytosol aminopeptidase
- Phospholipid hydroperoxide glutathione peroxidase GPX4
Sequence:
MAWGHRATVCLVLLGVGLGLVIVVLAAVLSPRQASCGPGAFTRAAVAADSKICSDIGRAILQQRGSPVDAAIAALVCTGVVNPQSMGLGGGVVFTIYNASTGKVEIINARETVPASYDQGLLNQCKNVLPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLREGFRVPFILSQFLNNSILRPHLSASTLRQLFFNGTETLRSQDPFPWPALANTLETVAKEGAEVLYTGRLGRMLVEDIAKQGSLLTVQDLAAFQPEVVEPLEMPLGNYTLYSPPPPAGGAILSFILNVLKGFNFSAETVARPGGEVNMYHHLVETLKFAVGQRWRLWDPSSHPGIQNISRDLLREDLAQRIRQQIDGRGDHHQLSHYNLTGVRGNRMGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDLCWRHMPTSPITPPPVPGERPPSSMVPSILVNKGQGSKLVIGGAGGELIISAVAQTIMNKLWLGFDLTEAIASPILHVNSKGHVEYEPKFNQEVQKGLQDRGQIQSQSQRPVFLNAVQAVFQEGPCVYAASDLRKAGKASGY
Protein: ADP-ribosylation factor-like 15b (ADP-ribosylation factor-like protein 15 isoform X1) (F1RDR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYWKPKAFYQDLFYLHNRAWDLQRRKRSTELTLLASRFIQILFLTSERRGVLSQSREKKSRLWMHSINGSVSFHSRLDSGILFSGENSKKLSRNYMDYLCFRTLCCKGPPPPRPEYDVVCIGLTGSGKTSLLSRLCSEATDNIVPTTGFSIKAVPFQNAILNVKELGGADSIKKYWSRYYQGSQGVVFVLDSASSEEDLEVARTELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFELEPLARGKSWILEGSTVDNMTAVKESFAQLIHLLEEKDQETGRI
Protein: NAD-dependent protein deacetylase Sirt2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog) (SIR2-related protein) (Q9I7I7)
Organism: Drosophila melanogaster (Fruit fly)
Function: NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span.
Interaction partners:
- Nicotinamide-nucleotide adenylyltransferase
- Glutamine-dependent NAD
- NAD
- Forkhead box protein O
- purine-nucleoside phosphorylase
- NAD kinase 2, mitochondrial
- Protein deacetylase HDAC6
- Histone deacetylase HDAC1
- Ankyrin repeat and LEM domain-containing protein 2 homolog
- Histone deacetylase 11
Sequence:
MDKVRRFFANTLHLGGSSDAKEEVKVEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKPQSDPDKMTSGDRDKKDASL
Protein: Partitioning defective protein 6 (Q9NAN2)
Organism: Caenorhabditis elegans
Function: Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9834192}. Cell membrane {ECO:0000269|PubMed:9834192}; Peripheral membrane protein {ECO:0000269|PubMed:9834192}. Cell junction, tight junction {ECO:0000250}. Note=Membrane-associated at the periphery of blastomeres up to about the 50 cell stage. Peripheral expression is asymmetric in the cells of the germline lineage P0, P1, P2 and P3 (PubMed:9834192). Asymmetric distribution in the 1-cell embryo is regulated by the cye-1/cdk-2 complex (PubMed:17115027). {ECO:0000269|PubMed:17115027, ECO:0000269|PubMed:9834192}.
Interaction partners:
- Protein kinase C-like 3
- Partitioning defective protein 3
- LGL-1
- Cell division control protein 42 homolog
- RING-type domain-containing protein
- MAGUK p55 subfamily member 5
- Serine/threonine-protein kinase par-1
- Disks large homolog 1
- GTPase-activating protein pac-1
- Ras-related protein ced-10
Sequence:
MSYNGSYHQNHHSTLQVKSKFDSEWRRFSIPMHSASGVSYDGFRSLVEKLHHLESVQFTLCYNSTGGDLLPITNDDNLRKSFESARPLLRLLIQRRGESWEEKYGYGTDSDKRWKGISSLMAQKPPKRSYSISNPEDFRQVSAIIDVDIVPEAHRRVRLCKHGQERPLGFYIRDGTSVRVTERGVVKVSGIFISRLVDGGLAESTGLLGVNDEVLEVNGIEVLGKTLDQVTDMMVANAHNLIITVKPANQRNTLSRGPSQQGTPNASEMSAATAAATGGIQRPMKMNGSSDGSYHPKQHDANDSDSGED
Protein: Fli-1 protein (Fli-1 proto-oncogene, ETS transcription factor a) (Friend leukemia integration 1) (Friend leukemia integration 1a) (Q9PU61)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Interaction partners:
- Vascular endothelial growth factor receptor kdr-like
- GATA-binding protein 1a.
- Rhombotin-2
- Myosin light chain 2 Mlc2a
- Runt-related transcription factor
- Vascular endothelial growth factor receptor 3
- Vascular endothelial growth factor A-A
- Endothelial transcription factor GATA-2a
- Neuronal PAS domain-containing protein 4-like
- Cadherin 5
Sequence:
MDGTIKEALSVVSEDQSLFEPPYAAAAPLPKTDMTASGTQDYGQTHKINPIPPQQEWINQPVRVNVKREYDHINGSRESPVDCSVGKCNKMVGGTEASQMNYTGYMDEKCAPPPNMTTNERRVIVPADPSLWSPDHVRQWLDWAIKEYGLQEIDTAMFHSTDGKELCKMSKDDFLRLTSVYNTEVLLSHLNYLRESSSSISYNTPSHADQSPRLAAKDDASYDAVRRTGWSNNMHSGKGSPTVVSQSVSKNPDQPRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANAGCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESTMYKYPSELPYVPSYHAHQQKVNFVSPHPPSMPVTSSNFFGPTTPYWSSPPGGIYPNPSVPRHANSHVPSHLGSYY
Protein: Cytochrome b5 (Microsomal cytochrome b5 type A) (MCB5) (P00167)
Organism: Homo sapiens (Human)
Function: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
Subcellular location: [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Interaction partners:
- NADH-cytochrome b5 reductase 3
- NADPH--cytochrome P450 reductase
- Cytochrome c
- NADH-cytochrome b5 reductase-like
- NADH-cytochrome b5 reductase 1
- NADH-cytochrome b5 reductase 2
- Myoglobin
- Stearoyl-CoA desaturase
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cytochrome b5 reductase 4
Sequence:
MAEQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTDAREMSKTFIIGELHPDDRPKLNKPPETLITTIDSSSSWWTNWVIPAISAVAVALMYRLYMAED
Protein: Ninja-family protein AFP1 (ABI five-binding protein 1) (ABI5-binding protein 1) (Q9LQ98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a negative regulator of abscisic acid (ABA) response during germination through the ubiquitin-mediated proteolysis of ABI5/DPBF1.
Subcellular location: Nucleus {ECO:0000269|PubMed:12569131}.
Interaction partners:
- Protein ABSCISIC ACID-INSENSITIVE 5
- WD repeat-containing protein DWA2
- THO complex subunit 6
- Transducin/WD40 repeat-like superfamily protein
- E3 ubiquitin-protein ligase KEG
- E3 ubiquitin-protein ligase AIP2
Sequence:
MAEANERSKEMARSNSCVFPRDLLQRFISNSVEGEDDDEEEDDDEIELNLGLSLGGRFGVDKSNKLVRSSSVVVTMPLFREDHHHHQAAAMITTKVSTETVAGATRGTGLMRTTSLPAESEEEWRKRKEMQTLRRMAAKRRRSEKLRTGVGGGNSNNPEEAATATASRRRGRPSSGLPRWSATANKSGLLRQHSAGLDSLQVSGESLGGGRAAGSSSSVSELETKASSDEARSLPSTTQPQQETTTKPTNRLRRLSSVDMNMKMEPQGKGKSEMPCVFTKGDGPNGKRVDGILYRYGSGEEVRIMCVCHGDFLSPADFVKHAGGPHVDHPLRHIVVNTSSPSNLL
Protein: Fibroblast growth factor 22 (FGF-22) (Q9HCT0)
Organism: Homo sapiens (Human)
Function: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 4
- Klotho
- Pro-epidermal growth factor
- Fibroblast growth factor-binding protein 1
- Fibroblast growth factor receptor 3
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Decorin
- Vascular endothelial growth factor receptor 2
Sequence:
MRRRLWLGLAWLLLARAPDAAGTPSASRGPRSYPHLEGDVRWRRLFSSTHFFLRVDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGRLYGSRLYTVDCRFRERIEENGHNTYASQRWRRRGQPMFLALDRRGGPRPGGRTRRYHLSAHFLPVLVS
Protein: Large ribosomal subunit protein uL3 (50S ribosomal protein L3) (BL3) (P42920)
Organism: Bacillus subtilis (strain 168)
Function: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity). Strongly stimulates 23S rRNA precursor processing by mini-ribonuclease 3 (MrnC); 20-30% DMSO can replace L3, suggesting the protein may alter rRNA conformation.
Interaction partners:
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL22
- Elongation factor G
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS4
Sequence:
MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAENDGYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIFSAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLLPGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK
Protein: Transcription initiation factor IIB-1 (General transcription factor TFIIB-1) (AtTFIIB1) (P48512)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Interacts with TBP2 and is required for activated transcription and possibly basal transcription. Plays important roles in pollen tube growth, guidance, and reception as well as endosperm development. Is partially functionally different from TFIIB2 and PBRP2.
Subcellular location: Nucleus.
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- TATA-box-binding protein 1
- TATA-box-binding protein 2
- General transcription and DNA repair factor IIH helicase subunit XPD
- DNA-directed RNA polymerase II subunit 4
- Transcription initiation factor TFIID subunit 2
- General transcription and DNA repair factor IIH subunit TFB2
- General transcription factor IIH subunit 2
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 7
Sequence:
MSDAYCTDCKKETELVVDHSAGDTLCSECGLVLESHSIDETSEWRTFANESSNSDPNRVGGPTNPLLADSALTTVIAKPNGSSGDFLSSSLGRWQNRNSNSDRGLIQAFKTIATMSERLGLVATIKDRANELYKRLEDQKSSRGRNQDALYAACLYIACRQEDKPRTIKEICVIANGATKKEIGRAKDYIVKTLGLEPGQSVDLGTIHAGDFMRRFCSNLAMSNHAVKAAQEAVQKSEEFDIRRSPISIAAVVIYIITQLSDDKKTLKDISHATGVAEGTIRNSYKDLYPHLSKIAPSWYAKEEDLKNLSSP
Protein: Sphingosine 1-phosphate receptor 4 (F1QC10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Sphingosine 1-phosphate receptor 1
- Sphingosine kinase 2.
Sequence:
MEVLRSFSSASSCPDVYNWTSNSLILEHYNYTGRLHHRKPSKKSVSAVTVLFLCFSVFIILENLMVLLAVLFRVRLRHRWIFICIANIALSDLLTGTSYVVNICMSGEQTFRLTPILWLFREGLLFVALAASIFSLLLIAVERYATMMKPVHQKTATKTYRVYIMMLLCWITAFIIGFLPLMGWNCVCDLRSCSTLLPLYSKSYILFALVIFFIILLTIGVLYFAIYCHVRSSTETISARSRKRSLRLLKAVISIVGVFMVCWGPLFILLLVDFFCYSRSCSPLFNPEWVIALAVLNSAMNPLIYSFGSLELRKAIATLLCCSCLKAGLCDPKTFMSKETSSTSGSRHSSLRNSFSKVRNLSTSPPPEPKNGKKTRLSSTTSCLSASSG