Protein: Serine/threonine-protein kinase ATR (EC 2.7.11.1) (ATM-like protein 1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (Ce-atl-1) (Q22258)
Organism: Caenorhabditis elegans
Function: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the checkpoint response to double-strand breaks (DSBs) after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1/p53 pathway. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites.
Subcellular location: Nucleus {ECO:0000269|PubMed:16319925}. Note=Recruited to stalled replication forks by rpa-1-coated single-stranded DNA. Recruited to processed double-strand breaks in a rpa-1 and mre-11-dependent manner.
Interaction partners:
- Serine/threonine-protein kinase ATM
- BRCT domain-containing protein
- Serine/threonine-protein kinase chk-2
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase chk-1
- Protein hsr-9
- Double-strand break repair protein mre-11
- RecQ-like DNA helicase blm-1
- ATP-dependent helicase wrn-1
- DNA repair protein RAD51 homolog
Sequence:
MNIDKDVSALLCTAKKYVTQKEFNRQKMKFLLDDITKLLSKSFVSRIEQLDENEFMEKIMILQSITFTLHLITEKQELSSEEKIRLFQSVIASMCAFEDEELAKCFDRILSVLMISVTKQDPRETIYFLQGLLEVVKYCDVEPSSSLPQLITPEIASAISLGASGFFRYHLKWNIISTLFGENAGECVHFDELVLFWPHCRSQLEDKLKNDCSMTENCLRAGLTILKYKKLHNSILDQALFIDELFATFNSLTAKKSTNHMTFPKLLNEIQHFLQDHGKVLIMHKELRQKPVQWLIIYLELIDDANDKFGLLENFSLLLLDLSTNHDIHEFPARLCMTASEICMRRIKHSIQSTHTDCLADYLDILASLLKLARIQKLDIFQCFATEIEAHHSLNNPLWPRILRSLLSVQNPHCQQFCKKFVPSIDKLWITLLNGESSRATLNSLVIVTASCPFANNNDEGVKQIIPFLLIPCFQDFRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVLERSTSESTKLRAVNCALQLEKKTGKYINLVAEMSLAVFSKSQTDRIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTLQKLFCLAANGRNSCKKCGEECFVDPDSKENVKIDYESLSGLIKGIVARRNTFSQELIREFLQTSRVMLLHVDSKGIASSFTSIIKALDIGFSENANAYFRVWELVCCRSEATVEKKLQMYIPLIGRSFALLGDDAALKVHGFLSNVLSARLSSTVKATLFASSFAHSVLKNCEIDWNVSYTWKTQFSQCLIKAPVGTCEEALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSYDEHRIREITRCYLSHVLSDFNFPNQKITFNMIRPSLLYWSLLSSARGINSKLTLSVIDFICQEMSAASVSMSSISPNPSDIRIVMIQRKSLITETFAQLVQFLAFENNRNTTSFWKFCSDHCDFKDEDIRTVISSYRKQVFMHLLLVSAREFLNPRNPSMIVEQLRATYENIKKGEKFMISTAIETRNEGIEFLFIFRTYFTNDQYFLTREATAESFRILLQNMKQDFFDTNWYIILMTLRQIPLNLDSTQSSWISFIEQINYSILRSNIWRILTDISRIENNDILIEKVWNRLSYDMVIDKISTDAMIKRVFWLIPLEVEKRIDLKFEISKSRQIEDVLEFIRMFPQYPSVQFADNLASKIERKTVYKEELPKLIGSLSRILPQCHSKREQNKIIKILQKLPIICSDLPDHNFIRWDTRFKFFCEPRQLTQAVLEDCAGIVEVMTGTSKIEYVDRTMCEIYKFFNPNEASPEMKSTLDGIKNMYAKMICSQKPEPSMIEQKTIDELSLGGSRRESFSRWLTVIILKCAEMSEDAPLSSLASIAHVDDTRFLSKLAMRFILTVIHMERDSVTQWILSTFEEALTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKVISFWKSMMSWTFKDENGHGQPLIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESETEAAYYFTLMNLYGRIHELNGVRGAYARLSRIQIDHVYGKISMREAFGDFNSAACFARMTGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYLNSLKTLSQWVNIDNDIGPSPHIFSRNIEYWATESTILKMIRNDERDEIVNNAIENAKSKVIERLSECAIGGSCSYEIATPFLVELQKLNEIVELKNVSNDELSAFNSDFWKNIQKRTDDSEQKISILEPILRVRRSMLDIRMQSMTGRDKENIRSRIVEVHLQSARIARLTGCFERAQLSLINAKKVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQSVNLDVQKSAKLKIEHYQEETKNLFSSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAHSGVMYEAAWLLDYLSNYKERSKHVLPLLKAYKEVAKYEKNQVLQARAVERMTSLWLSNTRKISTHISSVPKLPEGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPHQCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLSEKVDGLKTMFRDKKYDPKELVMNRRVDCDCKILSGIMVPVRSVIDESVHDTEIRDDGFEESCHLPDRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTSGEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADLPNLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGWMATL