wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein C26H8.13c (Q9P7Z8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MVIKRGFIGNTPKPSRCKRTKPIFREPNSPVNGGLVYNHPLHTAAAVKEAFSENRGFRTCHVCHRKNNMRLKVGTCESCKKHTCAICIRQCHKCESNVCSMCSKQERTFESEAFCPSCYPLDTY
Protein: EF-hand domain-containing protein (A0A060WU79)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Myosin, light chain 13
- EF-hand domain-containing protein
- Myosin, light chain 13
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
Sequence:
MSGKVTGCVAGFDLCLCFLKISALNCCETPNTMAPKKAKKKAAEASSNVFSMFEQAQIQEFKEAFTIMDQNRDGFIDKSDLRDTFCALGRLNVGNDELDEMLKMAPGPINFTIFLSMFGEKLKGTDPEETIINAFKIFDPEGQGVLKGEDIKYYIMSQADKFTEAEVEDMFTNFPLDVAGNLDYKNLCYVITHGEDKEAE
Protein: C2H2-like zinc finger protein (T1K7.4 protein) (Q9FZE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEEGKENSFLCKYCYKTFPSGKALGGHIRIHTNENSVGYNGNKKKRLVDQRKMMAQKHKQQQQVGCRECGRVFVSLKALRGHMACHGEVKKMLMDDNSQSDTESETSSAPMRKRSKRVVMKQSNSESLSNGSSSFGSEIDQERRDGAYNLMMLSSDSSSFKKRRNMVMNSLGESSDNNSAIVENKSSSGDEFKIMNVKNAVDDQWRSADDDGVSLCDSDGSDSDYFMNGPSKSESDISVDRNTGFGSGFNNSLIRFRNSNEGGTKYELSKSKRALFSYETDSCADTNSKIHHRFKDSKSSMVKKEGGEKVKSKGHECPICFRMFKSGQALGGHKRSHSIANHAAEMRNQIDLYLPVSDTDE
Protein: Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (Q54ZD1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS30
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS12
- Glutathione S-transferase domain-containing protein
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS17
Sequence:
MSQKQTKPAAATKAAPAKTAVATTKSKKVVKKGEKKIKTRTLFNALYTKNVKNFGTGFGVQPKRDLTHFTHWPRYIKLQRQRRVLLKRLKVPPTINQFTRVFDKNTAVHLFKLLDKYRPEEASVKKARLLKIAEARAATPKGQAAPKAEKPVQHLRFGIDSVTKLIEKKKAKLVVIAHDVDPVELVLYLPTLCRRMDVPYCIVKSKSRLGELVHMRNASCVALTGVNSADSNELALLVESAKQMFNNNSEHRKTWGGNTLSGPARAILAKRQKAEAKESLAKSKI
Protein: Mitochondrial carrier homolog 1 (Presenilin-associated protein) (Q9NZJ7)
Organism: Homo sapiens (Human)
Function: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (By similarity). Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis.
Subcellular location: Mitochondrion outer membrane {ECO:0000305|PubMed:12377771}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal membrane protein PMP34
- Presenilin-1
- Solute carrier family 25 member 10
- Mitochondrial dicarboxylate carrier
- Solute carrier family 25 member 3
- Solute carrier family 25 member 33
- Solute carrier family 25 member 16
- Mitoferrin-2
- Solute carrier family 25 member 32
- Mitochondrial 2-oxoglutarate/malate carrier protein
Sequence:
MGASDPEVAPWARGGAAGMAGAGAGAGARGGAAAGVEARARDPPPAHRAHPRHPRPAAQPSARRMDGGSGGLGSGDNAPTTEALFVALGAGVTALSHPLLYVKLLIQVGHEPMPPTLGTNVLGRKVLYLPSFFTYAKYIVQVDGKIGLFRGLSPRLMSNALSTVTRGSMKKVFPPDEIEQVSNKDDMKTSLKKVVKETSYEMMMQCVSRMLAHPLHVISMRCMVQFVGREAKYSGVLSSIGKIFKEEGLLGFFVGLIPHLLGDVVFLWGCNLLAHFINAYLVDDSVSDTPGGLGNDQNPGSQFSQALAIRSYTKFVMGIAVSMLTYPFLLVGDLMAVNNCGLQAGLPPYSPVFKSWIHCWKYLSVQGQLFRGSSLLFRRVSSGSCFALE
Protein: Large ribosomal subunit protein uL10m (39S ribosomal protein L10, mitochondrial) (L10mt) (MRP-L10) (39S ribosomal protein L8, mitochondrial) (L8mt) (MRP-L8) (Q7Z7H8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein uL22m
- Mitochondrial ribosomal protein L40
Sequence:
MAAAVAGMLRGGLLPQAGRLPTLQTVRYGSKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPSPPSPPQEEIGLIRLLRREIAAVFQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSKYQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQGFINYSKLPSLPLVQGELVGGLTCLTAQTHSLLQHQPLQLTTLLDQYIREQREKDSVMSANGKPDPDTVPDS
Protein: Non-specific lipid-transfer protein 2 (LTP 2) (Protein CELL GROWTH DEFECT FACTOR 3) (Q9S7I3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
Interaction partners:
- Non-specific lipid-transfer protein 9
- Non-specific lipid-transfer protein 15
- Carboxylesterase 20
- Dirigent protein 11
- Non-specific lipid transfer protein GPI-anchored 15
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
Sequence:
MAGVMKLACMVLACMIVAGPITANALMSCGTVNGNLAGCIAYLTRGAPLTQGCCNGVTNLKNMASTTPDRQQACRCLQSAAKAVGPGLNTARAAGLPSACKVNIPYKISASTNCNTVR
Protein: Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase) (O08701)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:O08691, ECO:0000250|UniProtKB:P78540}.
Interaction partners:
- Ornithine aminotransferase, mitochondrial
- Ornithine transcarbamylase, mitochondrial
- Ornithine decarboxylase
- Antizyme inhibitor 2
- Antizyme inhibitor 2
- Argininosuccinate lyase
- Nitric oxide synthase 1
- Nitric oxide synthase, inducible
- Nitric oxide synthase 3
- Glycine amidinotransferase, mitochondrial
Sequence:
MFLRSSVSRLLHGQIPCALTRSVHSVAVVGAPFSRGQKKKGVEYGPAAIREAGLLKRLSMLGCHIKDFGDLSFTNVPKDDPYNNLVVYPRSVGIANQELAEVVSRAVSGGYSCVTLGGDHSLAIGTISGHARHHPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIRELQDKVPQLPGFSWIKPCLSPPNLVYIGLRDVEPAEHFILKSFDIQYFSMRDIDRLGIQKVMEQTFDRLIGKRKRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGLYITEEIHSTGLLSALDLVEVNPHLATSEEEAKATASLAVDVIASSFGQTREGGHIAYDHLPTPSSPHESEKEECVRI
Protein: Trans-sialidase (Q583H4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEKRVIPTLYRHVLKKVVMITRMGAGRIALDRYAEYLPTAYVVGEGDGLSSIARKVFEETPLKACNVTNGFHFVKDVTDSVLDLEVLALWDAYTRKGECELLEGIAIVSAALRLAGVPEAKGDGDMTTLVNNTLCGLQSIVSDIRGILESSDFVSKVHRRRSYMSFLRSAVSVLQERGYSVSELVVEECSAESLVCSKKASAIVMNAVLVVVLRELGLQCTLAGVELQQPWIRVEKSNRAPIFLSFARAGAYTAEEVIGFAHESQRTHRSLHFTPWGMHCRRQILLAMLKRQLMMLSSDPKVSVVREKQQHMCQTQILFLLS
Protein: Nonstructural protein (Q4U3C0)
Organism: Bombyx mori densovirus 3 (isolate Silkworm/China/Zhenjiang/-) (BmDNV-3)
Interaction partners:
Sequence:
MLRLTDLHKPSCEPKGLSFYAYKAFIPYREKLSKEWNKLPVCIKDQEVDIKQEVKEDQLIRKIYKWDSVFDSWNWSKGYKLPKPLYELLEIYMKLWKLDNRTTYPDWGESSMIFKCYRYIRNKRMEDIENLSTEEFNDSNFNGWPKTMWYICRNCFDNGIVINNNSNDYYYTCDFSDNPTLLHYTDYFYYILNNDYWCYDCKYTPLFTLTTLFCLESINDSE
Protein: Protein HOR7 (Protein A0.5) (Q05827)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YDR524C-B
- Plasma membrane proteolipid 3
- Protein DDR2
- ATP synthase subunit J, mitochondrial
- Cytochrome c oxidase subunit 9, mitochondrial
Sequence:
MKLSQVVVSAVAFTGLVSAANSSNSSSSKNAAQPIAGLNNGKVAGAAGVALAGALAFLI
Protein: Melatonin receptor type 1C (Mel-1C-R) (Mel1c receptor) (CKB) (P49288)
Organism: Gallus gallus (Chicken)
Function: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Melatonin receptor type 1B
- Melatonin receptor type 1A
- Gonadotropin-inhibitory hormone
- Protein XRP2
- Serotonin N-acetyltransferase
- Acetylserotonin O-methyltransferase
- Vacuolar ATPase assembly integral membrane protein VMA21
Sequence:
MERPGSNGSCSGCRLEGGPAARAASGLAAVLIVTIVVDVLGNALVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILSAIFHNGWTMGNIHCQISGFLMGLSVIGSIFNITAIAINRYCYICHSLRYDKLFNLKNTCCYICLTWTLTVVAIVPNFFVGSLQYDPRIYSCTFAQTVSTSYTITVVVVHFIVPLSIVTFCYLRIWILVIQVKHRVRQDCKQKIRAADIRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPSKVQPHIPEWLFVLSYFMAYFNSCLNAVIYGLLNQNFRKEYKRILLMLRTPRLLFIDVSKGGTEGLKSKPSPAVTNNNQAEIHL
Protein: Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) (O62683)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions. Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (By similarity). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus. Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12021270}; Peripheral membrane protein {ECO:0000269|PubMed:12021270}; Cytoplasmic side {ECO:0000269|PubMed:12021270}. Cell junction, tight junction {ECO:0000269|PubMed:12021270, ECO:0000269|PubMed:9531559}. Nucleus {ECO:0000250|UniProtKB:O95049}. Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (By similarity). Shows an epithelial-specific tight junction localization in a TJP1/TJP2-dependent fashion (By similarity). {ECO:0000250|UniProtKB:O95049, ECO:0000250|UniProtKB:Q9QXY1}.
Interaction partners:
- PATJ crumbs cell polarity complex component.
- Occludin
- Claudin
- Claudin
- Claudin
- Claudin
- Claudin
- Claudin
- Claudin
- Claudin
Sequence:
MEELTIWEQHTATLCRDPRRGFGIAISGGRDRASGSVVVSDVVPGGPADGRLQTGDHVVMVNGVSMESVTSTFAIQILKTCTKLANITVKRPRKIQLPATKAGTSGRGRQGLEEEADCGQGYDGDTSSGSGRSWDKRSRRARTGRRNQAGSRGRRSPGGNSEANGLALVSGFKRLPRQDVHMRPVKSVLVRRTESEEFGVTLGSQIFIKHITDSGLAARNRGLQEGDLILQINGVSSENLSLSDTRRLIEKSEGKLTLLVLRDRGQFLVNIPPAVSDSDSDSSFLDDISALGSELSQAVPSHVPPPPPHAQRSLDSDGTDSPRDSPPLRRENSLDSRTISEPDAPRHSSYDIYRVPSSQSAEDRGYSPDSRVVRFHKGTTIGLRLAGGNDVGIFVSGVQEGSPADGQGIQEGDQILQVNDVPFRNLTREEAVQFLVALPPGEEVELVTQRNEDIFRKMVQSRVGDSFYIRTHFELEASPPSGLGFTRGDVFHVLDTLCPGPGPSGARGTHWLAVRMGRDLREQERGIIPNQSRAEQLASLESAQRAVGAGPGASVGSSARAEFWRLRGLRRGAKKSTQRSREDLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFGIADSVLRTDSPSKIIKLDTVRVIAEKNKHALLDVTPSAVERLNYVQYYPIVVFCAPESRAALKALRQWLAPASRRSARRLYAQAQKLRKHSEHLFTATIPLRGTSDTWYQELKAVVREQQTRPIWTAEDQLDNSSEDNLELPHRGLADSSADLSCDSRVNSDYETDGEGYTDGEGYTDVDEGPPAPALARSSEPVLEEEPRSPRDHGRASGARGAQVDRHPYHSQGRQDSMRTYGQEALKKKFTRARDVESSDEDGYDWGPATDL
Protein: Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) (Q99PN0)
Organism: Mus musculus (Mouse)
Function: Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland. Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:18372236}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q63008}. Cytoplasm {ECO:0000269|PubMed:18372236}.
Interaction partners:
- Thyrotropin receptor
- Thyroglobulin
- Thyroid peroxidase
- Pendrin
- Iodotyrosine deiodinase 1
- Paired box protein Pax-8
Sequence:
MEGAEAGARATFGPWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPSLAPRKLVFISKGLSFIYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLTAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMDSGRPAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTTTLEDSLVKGPEDIPAATKKPPGFRPEAETHPLYLGHDVETNL
Protein: DNA repair protein RAD50 (mRad50) (EC 3.6.-.-) (P70388)
Organism: Mus musculus (Mouse)
Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92878}. Chromosome, telomere {ECO:0000250|UniProtKB:Q92878}. Chromosome {ECO:0000250|UniProtKB:Q92878}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. Localizes to DNA double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q92878}.
Interaction partners:
- Double-strand break repair protein MRE11
- Nibrin
- Serine-protein kinase ATM
- DNA endonuclease RBBP8
- Breast cancer type 1 susceptibility protein homolog
- BRCA1-associated RING domain protein 1
- X-ray repair cross-complementing protein 6
- DNA repair protein RAD52 homolog
- Serine/threonine-protein kinase ATR
- Flap endonuclease 1
Sequence:
MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLCSQKNKKTEFKTLEGVITRMKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLKQNKEKACEIRDQITSKEAQLASSQEIVRSYEDELEPLKNRLKEIEHNLSKIMKLDNEIKALESRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLNKEARLLNQEKAELLVEQGRLQLQADRHQEHIRARDSLIQSLATHLELDGFERGPFSERQIKNFHELVKERQEREAKTASQLLSDLTDKEALKQRQLDELRDRKSGLGRTIELKTEILTKKQSELRHVRSELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEVMSLQNEKADLDRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDLESDLGRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPVRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHRLDTVTSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQSVELSTEVQSLNREIKDAKEQISPLETALEKLQQEKEELIHRKHTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLTLRKRRDELKEVEEEPKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNMDQCSEIVKCSISSLGSYVH
Protein: Large ribosomal subunit protein eL18B (60S ribosomal protein L18-B) (Q8TFH1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein eL18A
- Uncharacterized mitochondrial carrier PB17E12.12c
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein eS19B
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL6
Sequence:
MGIDIERHHVRKSQRSKPASENVYLKLLVKLYRFLARRTDSRFNKAILKRLFQSKTNRPPISISKIAALTSRKSASLEGKTTVIVGTVTDDERLLTVPKLSVAALRFTKSARARILKAGGEVLTLDQLALRAPTGSNTVLLRGKKHAREAYRHFGFGPHKHKAPYVRSEGRKFERARGRRKSRAFKV
Protein: Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog) (O70305)
Organism: Mus musculus (Mouse)
Function: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9668173}.
Interaction partners:
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- RNA binding protein fox-1 homolog 1
- Ataxin-3
- TAR DNA-binding protein 43
- Probable ATP-dependent RNA helicase DDX6
- Polyadenylate-binding protein 1
- Ataxin-2-like protein
- RNA-binding protein FUS
- Cytotoxic granule associated RNA binding protein TIA1
- Protein LSM12
Sequence:
MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPRGPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRASPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQSSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGPNSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL
Protein: Transient receptor potential cation channel subfamily M member 2 (A0A0R4IMY7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30250252}; Multi-pass membrane protein {ECO:0000269|PubMed:30250252}.
Interaction partners:
- Solute carrier family 24 member 6a
- Uncharacterized protein
Sequence:
MDEAALEPTLVQTLAVSTAKGGRYLSLSPSFQRCSLASWIKENIKKKECCFYVEDGREGICKCGYPKVQHCDEAIKPEDYMGEQWDKHRHVRETPTDAFGDISFGGLGQKTGKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAKNFYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEGRFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELRARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNTIYNSMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALINRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFRIDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEFVRLLLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKRVQGGKMRRGQEPLPGSRKVCLSHVSEEVRHLLGSFTQPLYIASRYKPTKDDVRLKVPSKGALDLPCSGEEWSADTVWDPGRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQESGEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALLTQIWCGELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDIQRQAERTEQQKLAMESVFAGQSDGKIKRHLRGFSQKSELKPLNCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRKAKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFYIGKVILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLDLFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYEPYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDNTDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFIRGVFLRDLPQRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSELLEREQEMVSATMAKRLARLEEQVSESAKALRWIIDALKSQGCKSKVQPPLMRSKSSDRDDGDSSGQETDDEEAPHMFARQLQYPDSTVRRFPVPEEKVSWEVNFSPYQPPVYNQQDSSESDTSALDKHRNPGGRTGIRGKGALNTLGPNHILHPIFTRWRDAEHKVLEFLAVWEDAEKRWALLGGPAQPDEPLAQVLERILGKKLNEKTKTLLKAGEEVYKGYVDDSRNTDNAWVETSIITLHCDKNTPLMADLNHMVESSLSSHQPLQWREVSSDACRCSYQREALRQIAHHHNTYF
Protein: Vacuolar amino acid transporter 5 (O74327)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:20388511}; Multi-pass membrane protein {ECO:0000269|PubMed:20388511}.
Interaction partners:
- Vacuolar amino acid transporter 3
- Uncharacterized transporter C460.03
- Vacuolar membrane amino acid uptake transporter fnx2
- GTP-binding protein gtr1
- Uncharacterized protein C119.18
- Multidrug resistance protein fnx1
- Autophagy-related protein 22
- DNA-directed RNA polymerase, mitochondrial
Sequence:
MSGYSPLSSGPADVHIGKAGFFSSVINLANTILGAGILSLPNAFTKTGLLFGCLTIVFSAFASFLGLYFVSQCAARLPRGKASFAAVAKHTFPSLAVVFDASIAVKCFGVAVSYLVIVGDLMPQIAPSLGLSSPMFLRRQTWIVFALFVLTPLSFLKRLDSLRHTSVISLIALCYLVFIVLYHFIIGDTVKGEIRYFVPESGFGYLSVLPVFVFGFTCHQNAFSVINEVRNFSQGFVNFTMFTAIISSTLLYLLVAITGYLSFGSLASGNIIAMYDNTSIWIIGGKLAIVVLVLFSYPLQCHPCRNSVYQAIRRSYSAHDMSDGYHAVITLCILLFTHSLALLLSSLEMVLAFVGSTGSTFISFILPGSLYYFFSHKVASPGNSSPLQLRISRAFAAGLAIYGTVVMILCLNINIAKLSH