wanglab/gogpt-training-data huggingface dataset:
Protein: Sedlin (Q38FR0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTAQSWAVAALALFSGDGKPLIIRTFTSPNSGHGGVPAVCRGGVFVGEEDVMRLHVLILSSLDRCDEIVQERRKQQMANVEKSGDGSASPRGSARVTAGADVRFLGKLIRSYTFTTYGFQSASGIRTVLAVVGDAPLDAVLPLCRSTYEAASAALCNPFCLTRTSAELLRRLCRTVRADIIGSDADVVKFFPLSARDAMDEDPSLANSRAFNMQIQTNIEPFTASAFT
Protein: Innexin-12 (Protein opu-12) (O01634)
Organism: Caenorhabditis elegans
Function: Structural component of the gap junctions (By similarity). Plays a role in oocyte directional transit in the spermatheca during ovulation by facilitating the directional propagation of the calcium signal in the spermatheca. Plays a role in male tail tip morphogenesis.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction {ECO:0000250}.
Interaction partners:
- Innexin
- Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
Sequence:
MNVIQNLLSAVSPQPDGDFVDKLNYCATTIGLVLASAFITGWSFVGSPIDCWFPAYYKGWWAEYALDYCYVQNTFFVPFSEDKAERSYNWEQLVADKQNTTSLKQTNQIGYYQWVPFILALQAMLFYFPVVIWRLFYGMAGQNVTSLCNTCTATEGNEESRKGTITTIAGYISQKRHRNLIVKQLSGFQNRANGSAVITSYLFMKALFLINVLFQFVLLKRMLGVDSYFWGAEVTSDLWSGNEWPETGNFPRVTMCEYEVRNLDNIHKHSVQCVLMINMFNEKIFVALWWWLCFLTVVTITNTIYWFWRASGTSVSKNFIRPYVEDIDPKVKNNRGKLQQFVSEFLSPDTVFILRLIELNNGKTPVVELIRDMWRRFNTAVPPPYSAPPLLVKDGAPLLKNFQDESEM
Protein: Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201) (Q9UNN8)
Organism: Homo sapiens (Human)
Function: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Thrombomodulin
- Vitamin K-dependent protein C
- Proteinase-activated receptor 1
- Coagulation factor X
- COX assembly mitochondrial protein 2 homolog
- Kinetochore-associated protein NSL1 homolog
- Coagulation factor VII
- Myeloblastin
- Tissue factor pathway inhibitor
- Vitamin K-dependent protein S
Sequence:
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
Protein: Leucine-rich repeat neuronal 1 (Leucine-rich repeat neuronal protein 1 precursor) (Lrrn1 protein) (A9JRH0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein phosphatase 1 regulatory subunit 27
Sequence:
MARGTFFLVVEGQICFILLLAVLGLSSVHSTECPQLCVCEIRPWFTPQSTYREATTVDCNDLHLTRIPGNLSADTQVLLLQSNYIARTSEELEQLLNLTELDLSQNNFSNIRDIGLTNMSQLTTLHLEENQIVEMPDFSLQDLTNLQELYINHNQISSIAPNAFAGLRNLLRLHLNSNRLKAIDSRWFESTPNLEILMIGENPVVGILDLNFKPLTNLRSLVLAGMELTDIPGNAFVGLDNLESLSFYDNKLVRVPQTALQKLPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSIDRFALDNLPELTKLEATNNPKFSYVSRLAFRDLPALESLMLNNNALNSLYQATADSLPNLREISIHSNPLRCDCVIQWMSSNKTTIRFMEPLSMFCTMPIEVRGQRVRDVFSREPSGQCLPMISHDTFPNHLNLDIGMTVDLDCRAMAEPEPEIYWVTPSGNKVMMDTVSDKYQLNSAGTLRISYIQVDDSGHYTCVAQNTEGADTRVTAIRVNGTLLDSTQLMKIYVKHTESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTAKVPVDVHEYNLTHLQPATEYEVCLSVSNIHQQTQKSCVNVTTKHATFAVEISEQGTNTALAAVMGTILAIISLGSITLYIAKRWKRKNYHHSLKKYMQKTSSIPLNELYPPLINLWEADSEKDKDGSSDNKQTQVDTTRSYYMW
Protein: Not1, isoform F (EC 3.1.13.4) (E2QCN4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNVESQLKTPPTHIRNLVKHVNKRNFNESSEQINQFVKEHGLEADRSSLRHLFSVINFSDLVPSVTVQLQAKLLGIQLERQLHSSSFVSNICYAFDQFFASNQKSLKPVAVADLVGQVARLTGINKVCECVFALALTHSSYTELKHSARNNLKGSLSELIDSYLGNKGTGPADSGLREISFDLLQYLLCCLSEYVQPQVEAQFLIKLREEFPRQAVPLVLAPFLYGSTTATIAGAGASETDAEAEATTNSNSSSFEADALNEVGIEDIYDHLSEIIFTNQGKNNIMDTSWINLILEIGYEFTSSVEECKNHLCSRERERAELQSKDVAKIVGLMCRRHSSLLDCNVNLPTPANFWPGQGQGGGSNSSGSSQTQITPQQQNPGSSNNNDGSDGNSSSDKKDKKETTEATQTWKPDVFVQALKEVVPQLNWKDVCMELDHPEFVLKDRIGLELLLTILRLATGSNIFPHPECIYRHWANTEGQLSLIATMLKNPDLFSFADFVFSQPALDVLKTAPDADNKEISSWKSLHLVEVLLSIADKGYYTQVHELFKFPAQNCPDVLFLALLNTSPPMTPLRQDLFNQLIPTFLGNHPNSNVILASAWSSNNFQLRSNIMNAMSEWYLRGNEFDQVKLSRILDLAQDLKALSALLNARSFLFIIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAKVPEDQLPPKQAQLLPETVTTMINCLQTCINNCMQPEMVEVIMQMTANVAIMANKARAQQQQQPGLVPPPPPTILRGHRGMDLPGGIVPPPPQQPFSGNLNAQMFGPGMDPLTNMSNNLAGLNLSGPNGAFNFGNMLTSPSRLMTPGANPYPLNLMQMPQAPPPPNVGNLGRMLPGGPQQQTPTPTPTAPNPNNPVMADLQIPVSKEVEDEVNSYFQRIYNHQPNPTLSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLFGGIIDRNLVPTFVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYVEYGMHGQEPPPQKLIGLSNTIPSAISSGPGTEPIYRNSSMLGNMPAATPGSGPKSNAAVSHATRMKSIANATNIDTLLVANQEEKVTVPPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKETLRNIKVLLRSDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQQELLFVVPFVAKILESSAKSRIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPNRTHRIEEQMSQPKPKQLEPVASAPALPREQQSPAQPPPPPQQQQPPQQQVPPPPSSADVDAQNAAAMMMAAGGANSTPGSVSSPNLPTDSSQVALPPPEPRYSYVDVNVSNFQLIGQQLVLPPNTPFLHANPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRMRTAAHQMVRNLAAGMAMITGKDEIARAISQNLHKALLSGLNGMPSMAEIQAAAMQLASENVELVCAFIQKTSAEKAAAEIDRRLSTDFETRKIAREEGNRFVDAQILTYQQERLPEAVRIKVGAAPATLYAVYSEFARSIPGFQQMSDRDIALFVPKPTDLSQPNVFANDDSMVYGELASKMEAFMNTAIGVPTLQIQASKMHMLLNALIATRRLRDQESAFNLLTRAVEGLTEGLVNMHENMEQMKMYQNIHLRILGLLNNSFGAPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNYVAISFGIALLERLIMDDRVINIVSDNEFMATVELLGRLTQHRHRYPECIVNAIDTLWSGNFNSSSDYSPFNGNDRYLSGASHYIHSGMHHVRSCDTDDPPGLQEKTEFLLKDWVALYTQQNQQSTRDARNFGAFVQKMNTYGILKTDDLITRFFRQATHICTDVVYRMFAEPSLPINQAKNKIFQWIDAFVHLIAMLVRHSGEAGNPTTKINLLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILVQIPGQKGWPLYAQLLQDLFKYLAPFLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELRGHLQVTSEPGTRYNMALMNALVMYVGTQAIALIRNKNFVPNTSNIAHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKYFGECLIVVKRFENSIGIQCAS
Protein: BZIP domain-containing protein (O16213)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Transcription factor zip-11
- C2H2-type domain-containing protein
- COX5B-domain-containing protein
Sequence:
MASCHEPSAFKSLCAHPSTLTATFDVSPYSSAFHLPIHPALLSNTHLLHLNTYNPTTYESTERLFEQNNNNSEKAESCSSRDSSHDSSSPTSTGGSSRDNVIVRNELKRKKDQVKDVAYWERRRKNNDAAKRSRDQRRMKEDEMAHRATSLERENMLLRVELDQLRAETDKLRALILTTPTTSISIPIPLQSLPLLTAQTAPASSVITTSQMYAPLPLKIPKTPSPSLLRSTVLVSNSSKT
Protein: Globin-coupled histidine kinase (EC 2.7.13.3) (AfGcHK) (Heme-based oxygen-sensor histidine kinase) (A7HD43)
Organism: Anaeromyxobacter sp. (strain Fw109-5)
Function: Member of the two-component regulatory system GcHK/Anae109_2439. Autophosphorylates in response to oxygen availability, and then transfers the phosphate group to a conserved Asp residue in the receiver domains of the cognate response regulator Anae109_2439, resulting in its activation.
Interaction partners:
- Response regulator receiver protein Anae109_2439
- histidine kinase
- Response regulator receiver protein
- Response regulator receiver protein
- Response regulator receiver protein
- Response regulator receiver protein
- Response regulator receiver protein
- Response regulator receiver protein
- Response regulator receiver protein
- Response regulator receiver protein
Sequence:
MTGVPETVFEELKRYVGWGDGDERALRSLHGAAAPHFPRLAEEFYDRILGHEGARTALVGGESQVGHLKVTMIAWLDELLGGPWDEAYWDRRYRIGRVHVRIGLPQHYMFGAMNVHRTGLARLAYERFHGDPPELERVRNALGKVLDLELAVMLHTYREDLLAQQARVERLSTFGQLVGSIGHDLRNPLGVIETSLYILRTRTGEDERARKHLDRIGEQLGVANGIITNLLDMIRDRPLAREPVELAAVVGGAAESVRRPTGVSLALEGLDALPPVEGDPGQLRQVFVNLLENAVFAASPEGVVAVRASRADGLVALDVEDSGPGVDPATRRRLFEPLITTKDKGIGLGLALVKRIAERHGGTVEYSDRPGGGARFTVRLPA
Protein: 2-succinylbenzoate--CoA ligase, chloroplastic/peroxisomal (EC 6.2.1.26) (Acyl-activating enzyme 14) (O-succinylbenzoyl-CoA ligase) (Q8VYJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of phylloquinone (vitamin K1). Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
Subcellular location: Plastid, chloroplast membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Accumulates in discrete foci within the chloroplast.
Interaction partners:
- Protein PHYLLO
- 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein mL43
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL13c
- Large ribosomal subunit protein uL3c
- Large ribosomal subunit protein bL21c
Sequence:
MANHSRPHICQCLTRLASVKRNAVVTVYGNRKRTGREFVDGVLSLAAGLIRLGLRNGDVVSIAAFNSDLFLEWLLAVALVGGVVAPLNYRWSLKEAKMAMLLVEPVLLVTDETCVSWCIDVQNGDIPSLKWRVLMESTSTDFANELNQFLTTEMLKQRTLVPSLATYAWASDDAVVICFTSGTTGRPKGVTISHLAFITQSLAKIAIAGYGEDDVYLHTSPLVHIGGLSSAMAMLMVGACHVLLPKFDAKTALQVMEQNHITCFITVPAMMADLIRVNRTTKNGAENRGVRKILNGGGSLSSELLKEAVNIFPCARILSAYGMTEACSSLTFMTLHDPTQESFKVTYPLLNQPKQGTCVGKPAPHIELMVKLDEDSSRVGKILTRGPHTMLRYWGHQVAQENVETSESRSNEAWLDTGDIGAFDEFGNLWLIGRSNGRIKTGGENVYPEEVEAVLVEHPGIVSAVVIGVIDTRLGEMVVACVRLQEKWIWSDVENRKGSFQLSSETLKHHCRTQNLTGFKIPKRFVRWEKQFPLTTTGKVKRDEVRRQVLSHFQIMTSSL
Protein: Secretory carrier-associated membrane protein 1 (AtSC1) (Secretory carrier membrane protein 1) (Q9SKT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in membrane trafficking.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Ras-related protein RABF2b
- RING-type E3 ubiquitin transferase
- Protein YIP
- GLABROUS1 enhancer-binding protein-like 1
- Transmembrane 9 superfamily member 1
- Post-GPI attachment to proteins factor 3
Sequence:
MSRYQSHSFDDGEINPFANPTSVPAATSKLSPLPPEPYDRGATMDIPLDSGKDLKAKEKELREKEAELKRREQEIKRKEDAIAQAGIVIEEKNWPPFFPLIHHDISNEIPIHLQRIQYVAFTSMLGLVVCLLWNIVAVTTAWIKGEGPTIWFLAIIYFISGVPGAYVMWYRPLYRAMRTDSALKFGWFFFTYLFHIAFCVFAAVAPPIIFKGKSLTGILPAIDVLSGNILVGIFYFIGFGFFCLESLVSIWVIQQVYMYFRGSGKAAEMKQEATRRAMMAAL
Protein: Cyclic nucleotide-gated channel alpha-4 (CNG channel alpha-4) (CNGa4) (Olfactory cyclic nucleotide-gated channel subunit 2) (OCNC2) (Q3UW12)
Organism: Mus musculus (Mouse)
Function: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
Subcellular location: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q64359}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel beta-1
- Cyclic nucleotide-gated channel alpha-2
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Calmodulin-1
- Calmodulin-4
- Calmodulin 5
- Cyclic nucleotide-gated channel beta-3
- Cyclic nucleotide-gated channel alpha-1
- Receptor-transporting protein 2
Sequence:
MSQDSKVKTTESTPPAPTKARKWLPVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLLYLLDIGVRFHTGFLEQGILVVDKSMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIPTLRLNRFLRVPRLFEAFDRTETRTAYPNAFRIAKLMIYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPLPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPDDMGEADDEAEPGEGTSKDGEEKAGQEGPSGLE
Protein: Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) (A0A8I6AF61)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAMGCGTTQCLYALCYDDPIKGPAAAMSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQEFNLSAYFERAADFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMLRQKMDVRSALSTVRQNREIGPNDGFLAQLCQLNDRLAEEGKDPWN
Protein: Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment] (P06681)
Organism: Homo sapiens (Human)
Function: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Subcellular location: Secreted.
Interaction partners:
- Complement C3
- Complement C4-B
- Complement C1q subcomponent subunit B
- Complement C1r subcomponent
- Complement C4-A
- Complement C1s subcomponent
- Complement C1q subcomponent subunit A
- Mannose-binding protein C
- Complement C1q subcomponent subunit C
- Mannan-binding lectin serine protease 2
Sequence:
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
Protein: Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family (Putative harpin-induced protein) (Q9SVC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MOK16
- At5g60630
- Probable leucine-rich repeat receptor-like protein kinase At5g49770
- ACT domain-containing protein ACR7
- Non-race specific disease resistance protein
- Probable cysteine protease RD21C
- Beta-glucosidase 15
- CHP-rich zinc finger protein
- AT5g02480/T22P11_70
- F25P12.91 protein
Sequence:
MSKDCGNHGGGKEVVVRKLCAAIIAFIVIVLITIFLVWVILRPTKPRFVLQDATVYAFNLSQPNLLTSNFQVTIASRNPNSKIGIYYDRLHVYATYMNQQITLRTAIPPTYQGHKEVNVWSPFVYGTAVPIAPYNSVALGEEKDRGFVGLMIRADGTVRWKVRTLITGKYHIHVRCQAFINLGNKAAGVLVGDNAVKYTLANKCSVNV
Protein: 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein UL83) (Q6SW59)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus. Inhibits also the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1. Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P06725}. Host nucleus {ECO:0000250|UniProtKB:P06725}. Host cytoplasm {ECO:0000250|UniProtKB:P06725}. Note=As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection. The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection. Thereafter, pp65 is probably exported and accumulates in the cytoplasm. Also found in dense bodies. {ECO:0000250|UniProtKB:P06725}.
Interaction partners:
Sequence:
MESRGRRCPEMISVLGPISGHVLKAVFSRGDTPVLPHETRLLQTGIHVRVSQPSLILVSQYTPDSTPCHRGDNQLQVQHTYFTGSEVENVSVNVHNPTGRSICPSQEPMSIYVYALPLKMLNIPSINVHHYPSAAERKHRHLPVADAVIHASGKQMWQARLTVSGLAWTRQQNQWKEPDVYYTSAFVFPTKDVALRHVVCAHELVCSMENTRATKMQVIGDQYVKVYLESFCEDVPSGKLFMHVTLGSDVEEDLTMTRNPQPFMRPHERNGFTVLCPKNMIIKPGKISHIMLDVAFTSHEHFGLLCPKSIPGLSISGNLLMNGQQIFLEVQAIRETVELRQYDPVAALFFFDIDLLLQRGPQYSEHPTFTSQYRIQGKLEYRHTWDRHDEGAAQGDDDVWTSGSDSDEELVTTERKTPRVTGGGAMASASTSAGRKRKSASSATACTAGVMTRGRLKAESTVAPEEDTDEDSDNEIHNPAVFTWPPWQAGILARNLVPMVATVQGQNLKYQEFFWDANDIYRIFAELEGVWQPAAQPKRRRHRQDALPGPCIASTPKKHRG
Protein: Type II secretion system protein I (T2SS minor pseudopilin I) (General secretion pathway protein I) (PilD-dependent protein PddC) (Q00516)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. Type II pseudopilus confers increased bacterial adhesive capabilities.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:8331069}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Type II secretion system protein J
- Type II secretion system protein K
- Type II secretion system protein H
- Type II secretion system core protein G
- Type II secretion system protein L
- Type II secretion system protein F
- Type II secretion system protein M
- Type II secretion system protein I
- Secretin XcpQ
- Type II secretion system protein E
Sequence:
MKRARGFTLLEVLVALAIFAMVAASVLSASARSLQNASRLEDKTLAMWIADNRLNELQLEQTPPSSGRNQGELEFAGRRWEWRTQVDSTAEQDMRRVIVWVAAKPLGRERGSIEERAAARLVGFLGSQP
Protein: T-complex protein 11 (O23129)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F5D14.24 protein
- OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 1
- RNA polymerase II C-terminal domain phosphatase-like
- Beta-galactosidase 4
- Transmembrane protein
Sequence:
MEEDRGEAIVLDISPEINNTPAVMMRVPRRIRERLLSDCSNKKTVSSVQDIEDKLLHAHLRRQQFYHNVSRKARAKPRSPSRSSDEELGQRIEARLLAAEQKRLEILAKAQMRLAKLDELRQAAKTSVEIRSERERVKLGTQVESRVQKAEANRMKILKASHQKRACAKERTSQSMMRRMARESKYKERVRASINQKRVAAEKKRLGLLEAEKKKARARVQQVRHVANSVSNQREIERSKMRDKLEDKLQRAKRYRSEFLRQRRRQRDSISLYCDMMQEDADLLSRKLSRCWRCFVRQKRTTLDLAKAYDGLKINESLPFEQLAMLLESLNTLKTVKSLLDRLEIRLEASKNVTTVSQPSILDNIDHLLKRVATPRRKATPSTLRSRKGKKVSSVRNVAGTSVKMSRYPVRVVLSAFMILGHPDAVFNGQGDQEAALNNAAKGFVRELKLLINVIQEGPVQVSGGESKHRTLRSQLDLFDKAWCSFLNSFVIWKVKDARLLEDDLVRAACQLELSMIQKCKLTPEGVDTMLTHDKKAIQMQVTQDQELLTEKVRHLSGVAGVERMESALLETRTKYFQAKEDGSPMANQLAHFFSPSPASSPVQSVSSSSSRSKDSIGVEGSNRVNRSLLKDDTPPSSGPSRVSNGTVDEVSNQNELMVNEFLHDGNLNFPGGSTVKDEEDNLKRRIKETMERAFWDNVMESMKLEKPDYSCISNLMKEVSDELCQMVPDSWKVEITETIDLDILSQLLNSGTLDIDYLGKMLEFALATLRKLSAPANDRENESTHRDLLKELHRLCEAEDESGNFRAVAIVKGIRFILEQIQELKREIGIGRIAIMKPFLQGPAGFDYLTKAFEKRYGPPTQAYESLPVTRRWISTLLSSKEEWEEHNNTLSALNVVERSSMGISLKTGGSFLSPVNTTSKSTVMDTAGQLSECKGERVDLAVRLGLLKLVNQVAGLTPEVLPETFQLNLFRVRDIQAEIQNIIVVTTSLLIWRQMLAKSESETESMAKKLLELLDGKEGAGLTEIIETTMSEEDGEKKKMMRGLLGKSLGEGNTVYERVTSCIYKAARGALLAGNGENGKRMVETEMKKVGGGGGLKERVLETARALGVVACVSVRVHGPWLTQLMPQH
Protein: Glycine-rich protein 23 (AtGRP23) (O48848)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein RRC1-like
- Glycine-rich protein 5
- Plasmodesmata-located protein 8
- Glycine-rich protein 3
Sequence:
MGLISGKVCVFIFVFALVAEFSFGNVEVNDDKHFFHKPRPFLHKPRPFLHKHGIYKKGFGKGLGGGGGLGGGGGLGGGGGLGGGGGLGGGGGLGGGGGLGGGSGLGGGGGLGGGSGLGGGGGLGGGGGGGLGGGGGLGGGAGGGYGGGAGGGLGGGGGIGGGGGFGGGGGGGFGGGAGGGFGKGIGGGGGLGGGYVGGGHH
Protein: Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) (P07607)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P04818}. Cytoplasm {ECO:0000250|UniProtKB:P04818}. Mitochondrion {ECO:0000250|UniProtKB:P04818}. Mitochondrion matrix {ECO:0000250|UniProtKB:P04818}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04818}.
Interaction partners:
- Dihydrofolate reductase
- Thymidine kinase, cytosolic
- Deoxyuridine triphosphatase.
- Methylenetetrahydrofolate reductase
- Serine hydroxymethyltransferase, cytosolic
- C-1-tetrahydrofolate synthase, cytoplasmic
- Thymidylate kinase
- Serine hydroxymethyltransferase, mitochondrial
- Deoxycytidylate deaminase
- Ribonucleoside-diphosphate reductase large subunit
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
Protein: Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin] (P80511)
Organism: Homo sapiens (Human)
Function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Subcellular location: Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Interaction partners:
- Advanced glycosylation end product-specific receptor
- Protein S100-A8
- Toll-like receptor 4
- Protein S100-A9
- Protein S100-A7
- High mobility group protein B1
- Interleukin-8
- Myeloperoxidase
- Interleukin-1 beta
- Natural resistance-associated macrophage protein 1
Sequence:
MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIALKAAHYHTHKE