wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin-like protein KIFC3 (O35231)
Organism: Mus musculus (Mouse)
Function: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11581287}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:11581287}; Peripheral membrane protein {ECO:0000305|PubMed:11581287}. Cell junction, adherens junction {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes along zonula adherens only at mature cell-cell contacts (By similarity). Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells. {ECO:0000250}.
Interaction partners:
- Kinesin-like protein KIF17
- Kinesin-associated protein 3
- Kinesin-like protein KIF3B
- Kinesin-like protein KIF3A
- Calmodulin-regulated spectrin-associated protein 3
- Kinesin-like protein KIF11
- Centrosomal protein of 170 kDa
- Kinesin light chain 2
- Kinesin heavy chain isoform 5A
- Kinesin light chain 1
Sequence:
MVPSRRTWNLGATPSLRGLWRVGRVQEPKPGMARPAPASPAARPFPHTGQGRLRTGRGKDILPSGEEDSTSRTAARPSLAQCRALSVDWPGPRSPHRLYLTVQVENLKEKLISQAQEVSRLRSELGGTDAEKHRDRLMVENEQLRQELRRCEVELQELRAQPVVPCEGCEHSQESSQLRDKLSQLQLEVAENKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQEEERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQTRNQHLQEQVAMQRQVLKEMEQQLQNSHQLTVQLRAQIAMYEAELERAHGQMLEEMQSLEEDKNRAIEEAFARAQVEMKAVHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDPDDDSIIHLLHKGKPVSFELDKVFSPWASQQDVFQEVQALITSCIDGFNVCIFAYGQTGAGKTYTMEGTPENPGINQRALQLLFSEVQEKASDWQYNITVSAAEIYNEVLRDLLGKEPQEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGYNNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVGKSGAEGNRLREAQHINRSLSALGDVIAALRSRQGHVPFRNSKLTYLLQDSLSGDSKTLMVVQVSPVEKNTSETLYSLRFAERVRSVELGPGSRRTELGSWSSQEHLEWEPACQTPQPTARAHSAPGSGTSSRPGSIRRKLQPSA
Protein: Fatty acid amide hydrolase (AtFAAH) (EC 3.5.1.99) (N-acylethanolamine amidohydrolase) (Q7XJJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of bioactive endogenous fatty acid amides to their corresponding acids. The hydrolysis of endogenous amidated lipids terminates their participation as lipid mediators in various signaling systems (Probable). Converts a wide range of N-acylethanolamines (NAEs) to their corresponding free fatty acids and ethanolamine. Can use oleamide as substrate, but not indole-3-acetamide, 1-naphtalene-acetamide, nicotinic acid amide or L-asparagine. Can use 2-arachidonylglycerol as substrate. Participates in the regulation of plant growth. Hydrolyzes N-dodecanoylethanolamine, which is has a growth inhibitory effect on seedling growth. Involved in plant defense signaling. Involved in abscisic acid (ABA) signaling through mechanisms that are independent of the catalytic activity. Involved in the regulation of flowering time. Catalyzes the hydrolysis of N-acyl L-homoserine lactones (AHLs), which are a class of signaling molecules produced by bacteria for quorum sensing. Accumulation of L-homoserine appears to encourage plant growth at low concentrations by stimulating transpiration, but higher concentrations inhibit growth by stimulating ethylene production.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18643971}. Cell membrane {ECO:0000269|PubMed:18643971}.
Interaction partners:
- Glutamyl-tRNA
- Aspartate--tRNA ligase, chloroplastic/mitochondrial
- SCP1-like small phosphatase 4
- Glutamate--tRNA ligase, chloroplastic/mitochondrial
- GMP synthase
- Germin-like protein subfamily 1 member 19
- At5g11860
- ABA-inducible protein-like
- glutamine--tRNA ligase
- Glutamine-tRNA ligase/glutaminyl-tRNA protein
Sequence:
MGKYQVMKRASEVDLSTVKYKAETMKAPHLTGLSFKLFVNLLEAPLIGSLIVDYLKKDNGMTKIFRNTVIPEEPMFRPEFPSQEPEHDVVIVGEDESPIDRLETALKCLPQYDPSRSLHADPVSSFRYWKIRDYAYAYRSKLTTPLQVAKRIISIIEEFGYDKPPTPFLIRFDANEVIKQAEASTRRFEQGNPISVLDGIFVTIKDDIDCLPHPTNGGTTWLHEDRSVEKDSAVVSKLRSCGAILLGKANMHELGMGTTGNNSNYGTTRNPHDPKRYTGGSSSGSAAIVAAGLCSAALGTDGGGSVRIPSALCGITGLKTTYGRTDMTGSLCEGGTVEIIGPLASSLEDAFLVYAAILGSSSADRYNLKPSPPCFPKLLSHNGSNAIGSLRLGKYTKWFNDVSSSDISDKCEDILKLLSNNHGCKVVEIVVPELEEMRAAHVISIGSPTLSSLTPYCEAGKNSKLSYDTRTSFAIFRSFSASDYIAAQCLRRRLMEYHLNIFKDVDVIVTPTTGMTAPVIPPDALKNGETNIQVTTDLMRFVLAANLLGFPAISVPVGYDKEGLPIGLQIMGRPWAEATVLGLAAAVEELAPVTKKPAIFYDILNTN
Protein: U1 small nuclear ribonucleoprotein, putative (Q57UW9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Sm protein F
- Sm protein G
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein SmD1
- Sm protein B
- U2 small nuclear ribonucleoprotein B, putative
- Small nuclear ribonucleoprotein SmD3, putative
- Small nuclear ribonucleoprotein, putative
- Spliceosome-associated protein, putative
Sequence:
MQTPGEEDLVHKKNAQRRVEEHMRWKAAFFQSRPPPPFVPQCRRRREPIASSPVHIFHKRALELVAAERPPVVSSSSMNAWPVAAAEKSDPKRSAWLEQMKSEMNRRNPYTDLNICSDPRCTVVMSGLHAKTVEEDIRIFSEQFGRVVSTRLIFDRNGHSRRYGFVQFGREADVQRAVASSGKRRLHGRSVVIDVERGRQEPEFLPKRIAKAVKLQGTSINSPVLPSGDTPIGKRQRNETERQQDRSREAPTKLEPSGGELRHRDDVDILLDDIMSIT
Protein: Ubiquitin-like protein 1 (O14399)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-conjugating enzyme ubc12
- Cullin-1
- RING-box protein pip1
- COP9 signalosome complex subunit 5
- Cullin-3
- NEDD8-specific protease 1
- NEDD8-activating enzyme E1 regulatory subunit
- mRNA export factor elf1
- COP9 signalosome complex subunit 4
Sequence:
MLIKVKTLTGKEIELDIDPNDKVSRIKERVEEKEGIPPSQQRLIYAGKQMADDKNAESYHLEGGSVLHLVLALRGGSC
Protein: Upstream stimulatory factor 1 (A0A0S2Z4U5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSDDAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN
Protein: Unconventional myosin-Ie (Myosin heavy chain myr 3) (Unconventional myosin 1E) (Q63356)
Organism: Rattus norvegicus (Rat)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated ve (By similarity)sicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function (By similarity). In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7730414}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7730414}. Cytoplasmic vesicle {ECO:0000305|PubMed:7730414}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Cell junction {ECO:0000269|PubMed:7730414}. Note=In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles (By similarity). Detected in cytoplasmic punctae. Colocalizes with F-actin. {ECO:0000250}.
Interaction partners:
- Synaptojanin-1
- Actin nucleation-promoting factor WAS
- Unconventional myosin-Ic
- Actin nucleation-promoting factor WASL
Sequence:
MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNINFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREDASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADIVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLTKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFYQGFGDLAILKPSNKVLQVSIGPGLPKNARPTRRNTVSSRGYSGGTNNNYPMRAAPAPPGCHRNGLTRNQFVHPPRASGNQRSNQKSLYTSMARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDVIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI
Protein: Probable prefoldin subunit 2 (Q9UTC9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Interaction partners:
- Probable prefoldin subunit 1
- Probable prefoldin subunit 6
- Probable prefoldin subunit 3
- Probable prefoldin subunit 5
- Probable prefoldin subunit 4
- Probable T-complex protein 1 subunit beta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit epsilon
- Probable T-complex protein 1 subunit eta
Sequence:
MAEQPSRQQILQTQYNSYKSRLQQIAQKIVDLETDADEHKLVMDTLNSMDNNRRCFRMIHGVLVERTVGTVVPILKTTQEGIQTAMNGLLDQYKQLEAEFQKFQKDNKIQVVRQ
Protein: Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1) (Q6NSN5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03126}.
Interaction partners:
- Adenylosuccinate lyase
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.
- Inosine-5'-monophosphate dehydrogenase 1a
- Inosine-5'-monophosphate dehydrogenase 1b
- AMP deaminase
- AMP deaminase
- Inosine-5'-monophosphate dehydrogenase 2
- Phosphoribosylglycinamide formyltransferase.
- AMP deaminase
- GMP reductase
Sequence:
MSSGWSQNDHRSYSNPPPVSGKRPRNDSGNKVTVVLGAQWGDEGKGKVVDLLATESDIVGRCQGGNNAGHTVVVEEKEYDFHLLPSGIINTKCTSFIGNGVVIHLPGLFEEIDKNEKKGLKGWEKRLVISDRAHIVFDFHQAVDGLQETQRQAQEGKNIGTTKKGIGPTYACKASRTGLRICDLMADFNEFSTRVKNLVQQYQSMYPTLKVDVESELKKLKEYAERIRPLVRDGVYFMYDAIHGPQKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPANIGDVYGVSKAYTTRVGIGAFPTEQLNAVGELLQTRGHEVGVTTGRKRRCGWLDLVILKYAHMINGFTAIALTKLDILDVLDEIKVGVAYKINGKRIPHFPANLEVLQKVEVEYETFPGWKSDTSAARKWGDLPAKAQNYIRFVENHIGVPIKWVGVGKSRECMIQMF
Protein: Bacteriophage SPP1 complete nucleotide sequence (O48490)
Organism: Bacillus phage SPP1 (Bacteriophage SPP1)
Interaction partners:
Sequence:
MARVVANTKDMPHEEWLALRKHGIGGSDAAKVLGVSKYGSPLTAYMEKKGMYTPKVSEATEEAARWGTIMEPVLRDEFRKRINEERAEQGLPPVRVEERHFLYAHEQFDFMRTNLDGVVLDHENGSGILEIKTASEYLKEEWEGEDIPNQYMIQVQHNIKVVEADFAYVVALIGGNKYKHYYIERDDELISHIVQGEHYFWNNHFSANIPPTASDSDAETEMMKILYPRSYDDPVLELPLEFKELAERYEDYKEQQKTLKKLETDAKNKLMAAMQESGIAFAGPHQITWRANKNGVKSFRVKLNKREEQKA
Protein: Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (P04351)
Organism: Mus musculus (Mouse)
Function: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Subcellular location: Secreted.
Interaction partners:
- Cytokine receptor common subunit gamma
- Interleukin-2 receptor subunit alpha
- Interleukin-2 receptor subunit beta
- Interleukin-4
- Tyrosine-protein kinase JAK3
- Interleukin-5
- Interleukin-1 beta
- Interleukin-6
- Interleukin-3
- Granulocyte-macrophage colony-stimulating factor
Sequence:
MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ
Protein: Alkaline nuclease (EC 3.1.-.-) (P04294)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.
Subcellular location: [Isoform UL12.5]: Host mitochondrion {ECO:0000269|PubMed:19129438}.; SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04009, ECO:0000269|PubMed:15078942, ECO:0000269|PubMed:3032315}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04009}.
Interaction partners:
Sequence:
MESTVGPACPPGRTVTKRPWALAEDTPRGPDSPPKRPRPNSLPLTTTFRPLPPPPQTTSAVDPSSHSPVNPPRDQHATDTADEKPRAASPALSDASGPPTPDIPLSPGGTHARDPDADPDSPDLDSMWSASVIPNALPSHILAETFERHLRGLLRGVRAPLAIGPLWARLDYLCSLAVVLEEAGMVDRGLGRHLWRLTRRGPPAAADAVAPRPLMGFYEAATQNQADCQLWALLRRGLTTASTLRWGPQGPCFSPQWLKHNASLRPDVQSSAVMFGRVNEPTARSLLFRYCVGRADDGGEAGADTRRFIFHEPSDLAEENVHTCGVLMDGHTGMVGASLDILVCPRDIHGYLAPVPKTPLAFYEVKCRAKYAFDPMDPSDPTASAYEDLMAHRSPEAFRAFIRSIPKPSVRYFAPGRVPGPEEALVTQDQAWSEAHASGEKRRCSAADRALVELNSGVVSEVLLFGAPDLGRHTISPVSWSSGDLVRREPVFANPRHPNFKQILVQGYVLDSHFPDCPPHPHLVTFIGRHRTSAEEGVTFRLEDGAGALGAAGPSKASILPNQAVPIALIITPVRIDPEIYKAIQRSSRLAFDDTLAELWASRSPGPGPAAAETTSSSPTTGRSSR
Protein: 16.6 kDa heat shock protein (OsHsp16.6) (Q943Q3)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSLVRSGNVLDPMSVDFWADADPFGAVRSLAERCPVLTNVRVDWKETPTAHVFTADLPGVRKDQAKVEVEDGGVLVISGERAREEDVDGKNDERWHHVERSSGKFQRRFRLPRGARVDQVSASMDNGVLTVTVPKEETKKPQLKAIPISG
Protein: C-X-C motif chemokine 11-1 (A0A0R4INB9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for cxcr3.2. Chemotactic for macrophages.
Subcellular location: Secreted {ECO:0000305|PubMed:25573892}.
Interaction partners:
- C-X-C chemokine receptor type 3-2
- Chemokine
- C-X-C chemokine receptor type 3
- Chemokine
- Chemokine
- Chemokine
- C-C motif chemokine
- Chemokine
- Stromal cell-derived factor 1
- Chemokine
Sequence:
MKTVTALLLVSLAVVAIEGQHMKSQRCVCLGAGLNMVKPVLIEKIEILPSSPSCGHMEVIATLKNGAGKRCLNPKSKFTKKIIDKIEKNNRNAR
Protein: Agglutinin alpha chain (Jacalin alpha chain) (P18670)
Organism: Artocarpus integer (Jack fruit) (Artocarpus integrifolia)
Function: D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
Interaction partners:
Sequence:
GKAFDDGAFTGIREINLSYNKETAIGDFQVVYDLNGSPYVGQNHKSFITGFTPVKISLDFPSEYIMEVSGYTGNVSGYVVVRSLTFKTNKKTYGPYGVTSGTPFNLPIENGLIVGFKGSIGYWLDYFSMYLSL
Protein: Tonoplast dicarboxylate transporter (AttDT) (Sodium-dicarboxylate cotransporter-like) (AtSDAT) (Vacuolar malate transporter) (Q8LG88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative carrier protein indirectly involved in the uptake of malate and fumarate to the vacuole, probably by regulating the energization across the tonoplast. Uptake of malate to vacuoles is inhibited by citrate and by the uncoupler carbonyl-cyanide m-chlorophenylhydrazone, but seems to be not affected by sodium. Critical for pH homeostasis.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:12947042}; Multi-pass membrane protein {ECO:0000269|PubMed:12947042}. Note=Tonoplast.
Interaction partners:
- Aluminum-activated malate transporter 9
- Aluminum-activated malate transporter 6
- Phosphoenolpyruvate carboxylase kinase 1
- Aluminum-activated malate transporter 1
- Aluminum-activated malate transporter 2
- Putative aluminum-activated malate transporter 3
- Aluminum-activated malate transporter 10
- Pyruvate, phosphate dikinase regulatory protein 1, chloroplastic
- Pyruvate, phosphate dikinase 1, chloroplastic
Sequence:
MNGGDVTVAGSDDLKSPLLPVVHNDEPFERQTVGQQLRTIFTPKNCYIALGPLLCAVVCLCVDLGGDETTTARNMLGVLVWMFAWWLTEAVPMPITSMTPLFLFPLFGISAADDVANSYMDDVISLVLGSFILALAVEHYNIHRRLALNITLVFCVEPLNAPLLLLGICATTAFVSMWMHNVAAAVMMMPVATGILQRLPSSSSTTEVVHPAVGKFSRAVVLGVIYSAAVGGMSTLTGTGVNLILVGMWKSYFPEADPISFSQWFFFGFPLALCIFVVLWCVLCVMYCPKGAGQALSPYLHKSHLRRELDLLGPMNFAEKMVLAVFGGLVVLWMTRNITDDIPGWGRIFAGRAGDGTVSVMMATLLFIIPSNIKKGEKLMDWNKCKKLPWNIVLLLGAGFAIADGVRTSGLAEVLSKGLVFLETAPYWAIAPTVCLIAATITEFTSNNATTTLLVPLLIEIAKNMGIHPLLLMVPGAIGAQFAFLLPTGTPSNVVGFTTGHIEIKDMIKTGLPLKIAGTIFLSILMPTLGAYVFASMGGV
Protein: Ethylene-responsive transcription factor ERF104 (Q9FKG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mitogen-activated protein kinase 6
- 1-aminocyclopropane-1-carboxylate synthase 6
- Probable WRKY transcription factor 33
- Mitogen-activated protein kinase 3
- Probable WRKY transcription factor 40
- Protein MKS1
- Mitogen-activated protein kinase 4
- Mitogen-activated protein kinase kinase 9
- 1-aminocyclopropane-1-carboxylate synthase 2
- Zinc finger protein ZAT10
Sequence:
MATKQEALAIDFISQHLLTDFVSMETDHPSLFTNQLHNFHSETGPRTITNQSPKPNSTLNQRKPPLPNLSVSRTVSTKTEKEEEERHYRGVRRRPWGKYAAEIRDPNKKGCRIWLGTYDTAVEAGRAYDQAAFQLRGRKAILNFPLDVRVTSETCSGEGVIGLGKRKRDKGSPPEEEKAARVKVEEEESNTSETTEAEVEPVVPLTPSSWMGFWDVGAGDGIFSIPPLSPTSPNFSVISVT
Protein: Karyopherin subunit alpha 1 (C9JYI4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDD
Protein: Kinesin-like protein kif7 (Kinesin-like protein costal2) (Q58G59)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15647323}. Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Suppressor of fused homolog.
- GLI family zinc finger 2a.
- GLI family zinc finger 3.
- Protein smoothened
- GLI family zinc finger 1
- GLI family zinc finger 2b.
- non-specific serine/threonine protein kinase
- Protein patched homolog 1
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
Sequence:
MSPKGVGHSKVEESAVQVAVRVRPLLPKEILHSHESCITSDPEERRVTLGNDRHFHCDFVFEDGSTQEEVYTNCVQPLIEAFFHGFNATVSAYGQTGSGKTYTIGEASISAFRDDEQGIIPRAVAEIFKLLDENDLIDFSVRVSYMEVYKEVFRDLLEVETASKDIHIREDERGNVVLCGVKECEVEGLDEVLSLLESGKTARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFVDLAGSERILKTGNTGERLKESIQINSGLLVLGNVIGALGDPKRKGTHIPYRDSKITRILKDSLGGNAKTLMIACISPSSSDFDESLNTLNYAKRARNIQNRATVNCRGEPDRIEGLELQIKALRRALENRQRSETRIIARSDPEKRLRPFEVDVRKLQAESAHYRTCTDSAYRLLTELQGEGTLNAGQILRVKEWLCGVEEERSGLTSASGLDSGIESSSTEDSTALKRRQAVLNNQDLVKEDWRGEREDYTSQLQAQIQQLEQENTDFLVALEDAMEQYKQQSDKLQEQQDLIAELHSLLAQPGGAGFLHLKQRPHTAPINSLLQTPDRLTPPCDSDVGRSLARQLDVGASVDSSSYSEQTQWDGTHGNTHCESSRKLNRDEDGHMQTTRDKRKSINVTWTKKDIAIPQGPFGGTRTALPQTLGLCHPLGMQFNRRTSNSSIGESSVWESVRGFGGEFCSDRGLLQAQQKIRELSITIRMKEELIKELVKTGKDAQAMNRQYSRKISELEAEAEQARVELTEAQKQLQELEVQGGRDAVDRSKAQECRRKIAAAQSKVQVLKQKQRDTAQLASLSAQSERRVQELERNVQNMKQQQDLLQRRLREESQQKRRLETEMQKGKHRVKELEIKNEQQQKILRIKTEEIAAFQRQRRSGSNGSVVSLEEQQKIEEQKRWLDEEMEKVLDQRRGLEDLEGELTKREEILAKKEALLWERSGLESKKLRSSQALSQDLLTLSSRIESLERELTERNGLLRSGSAQDSQQIRQEISNLRQEKELLLKQRVELDDKLRQGNLLSPEEERTLFQLDEAIEALDAAIEYKNEAITQRQRQLRASGSMLTQWEMNLMAKLTYLSASETRALLCKYFDKVVSLREEERRLQMALAELELRVEEQQNLVGWLEAALERQQLEADRRLTQQQKEHERNIQLLLQQCREQMDEGLAGRLRQYEGLIHNLSKELNFCKIANQELNIKLREMCGPVNLTGEQCKGLNCDSLLLAGAQSRVAEDVKPIIDAERVQKSREEMREPVNAPLPATWRRSSLPTEDQYTMEELRQRAACELPNNRIVQPGMNSTHWSGSTSLPVTRPRREPRRSSLNTAPLYSSSAIIDVRRNPV
Protein: Acetyl-CoA acetyltransferases subfamily (O51136)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- diphosphomevalonate decarboxylase
- mevalonate kinase
- Acetate kinase
- Phosphomevalonate kinase, putative
Sequence:
MIKKVAIIDGLRTPNFKFGGSFKGLNIIDESSKVVKALLERNKLYKVDEVIIGNVISAGLGQNIARQIALKSDLGDTVPAFSVNKVCGSGLKALELAFNSIALGDNDIVLAGGVEDLTNSPYLLPRKIRFDGLKFGNFGIEDSIQKDALIDSLNFISMGLTAENLSEKYRITREMQDEFAYNSHVKALKARELGYFEDEIYPLTVFDKKTNSSVTISSDEEIRDNLTLNKLASLNPVFKESGTVTAGNSSSLNDGACFLILASEERVKSLGLSPLAYIGGFKSVGLDPLYMGFGAYMAIEGIISKLSLNPSEIDLIEVNEAFAAQALSIEKALFKKYNITSDIINVNGGAIALGHPFAVSGSRILLTLSRSMKMKNKTKGIASVCIGGGQGISSFLYR
Protein: Putative electron transport protein YccM (P52636)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Ferredoxin-type protein NapF
- Hydroxylamine reductase
Sequence:
MAENKRTRWQRRPGTTGGKLPWNDWRNATTWRKATQLLLLAMNIYIAITFWYWVRYYETASSTTFVARPGGIEGWLPIAGLMNLKYSLVTGQLPSVHAAAMLLLVAFIVISLLLKKAFCSWLCPVGTLSELIGDLGNKLFGRQCVLPRWLDIPLRGVKYLLLSFFIYIALLMPAQAIHYFMLSPYSVVMDVKMLDFFRHMGTATLISVTVLLIASLFIRHAWCRYLCPYGALMGVVSLLSPFKIRRNAESCIDCGKCAKNCPSRIPVDKLIQVRTVECTGCMTCVESCPVASTLTFSLQKPAANKKAFALSGWLMTLLVLGIMFAVIGYAMYAGVWQSPVPEELYRRLIPQAPMIGH