wanglab/gogpt-training-data huggingface dataset:
Protein: histidine kinase (EC 2.7.13.3) (Q76H00)
Organism: Zea mays (Maize)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MTVTARGRSGGAGMGEKGGAPGLGFLSLDRMRVLLPPLRLPEKLSARTLRTHLFTNYRMRKVRDSSSWLIPLWVSSWVLVASLIYLCMSYQAVGKRRESLASMCDERARMLQDQFNVSMNHLQALAILVSTFHHSKTPSAIDQKTFARYAERTAFERPLTSGVAYGVRVTHAEREQFERQQGWSIKKMYSSKTKNQSQGPGNAEDAEVREPAEEYAPVIFAQDAYKHVISFDLLSGADDRDNVLRARESGKGVLTAPFKLLNNRLGVIFTYAVYKYELPANARPQERIQAAIGYLGGIFDIEALVDKLLHQLAGKQSIMVNVYDTTNERPISMYGSNDTGSGMCQVSTLNFGDPSRKHVMHCRFIQSPPWPWMAITTSIGTLVIALLIGYIVHATAKRIARVEDDFQEMSLLKKRAEDADIAKSQFLATVSHEIRTPMNGVLGMLQMLMDTDLDTTQQDYVRTAQASGKTLVSLINEVLDQAKIESGKLELEVVPFDLRTVCDDILSLFCGKAQEKGLELAVFVSDQVPQTLIGDPGRIRQIITNLVGNSIKFTEKGHIYLTVHVVEEIMHCLEVETGIQYTNTLSGYPVANRKRSWENFRLFSRELNSSEMPFAPIASDSISLMISVEDTGAGIPFDAQSRVFTPFMQVGPSIARIHGGTGIGLSISKCLVGLMKGEIGFASKPQVGSTFTFTAVLTRVHSSRNENKSSEFKEINALVVDHRPVRAKVTKYHLQRLGVQTELTTDLDQYISKNNCGSQIAKLVLIDKETWLKESHSMPLLVTKLRNKDQPDSTKLFLLENPKSSVKSNSHIFREYNLNVIMKPLRASMLQVSLQRALGGIDKLHCRNGVVGNSTLGSLLHKKRIIVVDDNIVNLKVAAGALKKYGAEVTCADSGKEAITLLKPPHNFDACFMDIQMPEMDGFEATKRIRVMERDLNEQIERGEAPPECVGVRQWRTPILAMTADVIQATHEQCLKSEMDGYVSKPFEGEQLYREVARFFLNQDQVQ
Protein: SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) (P07214)
Organism: Mus musculus (Mouse)
Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:3427055}. Note=In or around the basement membrane.
Interaction partners:
- Albumin
- Vascular cell adhesion protein 1
- Osteopontin
- Osteocalcin-related protein
- Osteocalcin-2
- Osteocalcin
- Collagen alpha-1
- Lumican
- Collagen alpha-2
- Fibronectin
Sequence:
MRAWIFFLLCLAGRALAAPQQTEVAEEIVEEETVVEETGVPVGANPVQVEMGEFEDGAEETVEEVVADNPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI
Protein: AT3G11930 protein (Adenine nucleotide alpha hydrolases-like superfamily protein) (B9DG73)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3G03270 protein
- AT4G23670 protein
- F-box/kelch-repeat protein At5g60570
- F-box protein At1g30200
- AT4g27450/F27G19_50
- Probable methyltransferase PMT24
- At5g27920
- 6,7-dimethyl-8-ribityllumazine synthase, chloroplastic
- MLP-like protein 328
- Tetratricopeptide repeat protein SKI3
Sequence:
MAEEQAATAMETSAVEKQPETTTEAEAPSLTTKRMVVAIDESDSSFYALQWVIDHFSNLLLTTAAAEAESGMLTVIHVQSPFNHFAAFPAGPGGATAVYASSSMIESVKKAQQETSAALLSRALQMCRAKQIRTETLVLEGEAKEMICEAVEKMHVDLLVVGSRGLGKIKRYCIINNFFLYINLSAYYFVCFVRFGRAFLGSVSDYCAHHANCPILIVKPPKEMTK
Protein: KASH (Klarsicht/ANC-1/Syne Homology) Domain Protein (Q95PZ1)
Organism: Caenorhabditis elegans
Interaction partners:
- Nuclear migration and anchoring protein unc-84
- Sun domain-containing protein 1
- Nuclear migration protein unc-83
- Zygote defective protein 12
- Transmembrane protein 201 homolog
- Nuclear anchorage protein 1
Sequence:
MSLALRKTLGVARFSMRTASFQAVPTNAGKTPPTLEQFDPLNPGEWQLGAGGKILPRLPEGTKCGNLVMGKYGLYDPILKKRVDTYANALLEGKKSEEAGPFDVAVSKIAKVLSYICFVIAIYNLISLVNGTPLPPLSHVKAPGS
Protein: Cytokinin dehydrogenase 2 (EC 1.5.99.12) (Cytokinin oxidase 2) (OsCKX2) (QTL grain number 1a) (Gn1a) (Q4ADV8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. Is a major QTL involved in grain yield. Modulates the number of reproductive organs by regulating the cytokinin accumulation in inflorescence meristems. Acts as negative regulator of panicle branching.
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:Q9FUJ3}.
Interaction partners:
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- Malate synthase
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Cytochrome c oxidase subunit 3
Sequence:
MKQEQVRMAVLLMLNCFVKATAPPPWPPSASSASFLDDLGDLGIAPLIRADEAGTARASADFGNLSVAGVGAPRLAAAAAVLYPSRPADIAALLRASCARPAPFAVSARGCGHSVHGQASAPDGVVVDMASLGRLQGGGARRLAVSVEGRYVDAGGEQLWVDVLRASMAHGLTPVSWTDYLHLTVGGTLSNAGISGQAFRHGPQISNVLELDVITGVGEMVTCSKEKAPDLFDAVLGGLGQFGVITRARIPLAPAPARARWVRFVYTTAAAMTADQERLIAVDRAGGAGAVGGLMDYVEGSVHLNQGLVETWRTQPQPPSPSSSSSSSFFSDADEARVAALAKEAGGVLYFLEGAIYFGGAAGPSAADVDKRMDVLRRELRHERGFVFAQDVAYAGFLDRVHDGELKLRAAGLWDVPHPWLNLFLPRSGVLAFADGVFHGILSRTPAMGPVLIYPMNRNKWDSNMSAVITDDDGDEVFYTVGILRSAAAAGDVGRLEEQNDEILGFCEVAGIAYKQYLPYYGSQAEWQKRHFGANLWPRFVQRKSKYDPKAILSRGQGIFTSPLA
Protein: UPF0758 protein YkfG (Q47685)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YkfH
- Uncharacterized protein YafX
- Antitoxin YafW
- Toxin YkfI
- UPF0401 protein YkfF
- DNA mismatch repair protein MutS
Sequence:
MKQLSFLPGEMTPQDRRLIQRALRALDRHLHEPGVAFTSTHAVREWLRLHMAALEREEFRVLYLDNQNQLIAHETLFTGTINRTEVHPREVVKRALHFNAAAVILAHNHPSGETTPSQADKTLTQRLVQVLQLVDIRVPDHLIVGGRQIYSFAEHGLL
Protein: 4-hydroxyphenylalkanoate adenylyltransferase (EC 6.2.1.51) (Acyl-AMP synthase) (FAAL29) (Long-chain-fatty-acid--AMP ligase FadD29) (FAAL) (P95141)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phenolphthiocerol, which is an important intermediate in the biosynthesis of phenolic glycolipid (PGL), also called mycosid B.
Interaction partners:
- Chorismate pyruvate-lyase
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15
- p-hydroxybenzoic acid--AMP ligase FadD22
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
- Peptide synthetase MbtE
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Phenolphthiocerol/phthiocerol polyketide synthase subunit E
- Peptide synthetase MbtF
Sequence:
MKTNSSFHAAGEVATQPAWGTGEQAAQPLNGSTSRFAMSESSLADLLQKAASQYPNRAAYKFIDYDTDPAGFTETVTWWQVHRRAMIVAEELWIYASSGDRVAILAPQGLEYIIAFMGVLQAGLIAVPLPVPQFGIHDERISSALRDSAPSIILTTSSVIDEVTTYAPHACAAQGQSAPIVVAVDALDLSSSRALDPTRFERPSTAYLQYTSGSTRAPAGVVLSHKNVITNCVQLMSDYIGDSEKVPSTPVSWLPFYHDMGLMLGIILPMINQDTAVLMSPMAFLQRPARWMQLLAKHRAQISSAPNFGFELAVRRTSDDDMAGLDLGHVRTIVTGAERVNVATLRRFTERFAPFNLSETAIRPSYGLAEATVYVATAGPGRAPKSVCFDYQQLSVGQAKRAENGSEGANLVSYGAPRASTVRIVDPETRMENPAGTVGEIWVQGDNVGLGYWRNPQQTEATFRARLVTPSPGTSEGPWLRTGDLGVIFEGELFITGRIKELLVVDGANHYPEDIEATIQEITGGRVVAIAVPDDRTEKLVTIIELMKRGRTDEEEKNRLRTVKREVASAISRSHRLRVADVVMVAPGSIPVTTSGKVRRSASVERYLHHEFSRLDAMA
Protein: Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP) (P55108)
Organism: Rattus norvegicus (Rat)
Function: Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P97737}.
Interaction partners:
- Activin receptor type-1B
- Activin receptor type-2A
Sequence:
MAPGLARISLRSQLLPLVPLLLLLRGAGCGHRVPSWSSLPSAADSVQRDRDLQQSPGDAAAALGPGAQDIVAVHMLRLYEKYNRRGAPPGGGNTVRSFRARLDVIDQKPVYFFNLTSMQDSEMILTATFHFYSEPPRWPRAREVFCKPRAKNASCRLLTPGLPARLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAARRDGELLLSAQLDSGEKDLGVPRPSSHMPYILVYANDLAISEPNSVAVTLQRYDPFPAGDFEPGAAPNSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQHFHKHEFWSSPFRALKPRTGRKDRKKKDQDTFTPSSSQVLDFDEKTMQKARRRQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVETCACR
Protein: Phosphatidyl synthase (A0A1D8PNE5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Carbonic anhydrase
- Methylenetetrahydrofolate dehydrogenase [NAD
- Ribulose-phosphate 3-epimerase
Sequence:
MTKEQSNNDSKNSVVVEEDGGAQFQSYLNNDGIDELTPSVRKHRVSSLSLSDLNQWQNGLTKLSSSTSLSKKNSSSANLKKVDSLAKLSRNASIIKRKKKEIIDHERVASYAFCFDIDGVILRGPDTIPQAVEAMKLLNGENKYHIKVPSIFVTNGGGKPEQQRADDLSKRLNCTITKEQIIQGHTPMKDLVDVYKNVLVVGGVGNVCRNVAESYGFKNVYTPLDIMKWNPAVSPYHDLTEEERVCTKDVDFHKIPIDAIMVFADSRNWAADQQIILELLLSVNGVMGTQSKTFDEGPQIYFAHSDFIWATNYKLSRYGMGALQVSIAALYREHTGKELKVNRFGKPQKGTFKFANKVLSHWRQGVLDEHLKKLSVNDPNANDADILINEDGEEIINQAKLENYNWSDSEDDEEDDDTVNGGSSTAKKALKDVGKIADVGKPDKITLELPPASTVYFVGDTPESDIRFANSHDASWHSILVKTGVYQAGTEPKYKPKHLCNDVLEAVKYAIEREHAMELAEWNETAQDVNEDDKGSRLNFADLVMTPSDKKENDTTEKKPSGASSTSKSSIAEAEEVEVPDILAAQIEKLKDVSVSK
Protein: Testis-specific Y-encoded-like protein 4 (TSPY-like protein 4) (Q9UJ04)
Organism: Homo sapiens (Human)
Interaction partners:
- Nucleosome assembly protein 1-like 5
Sequence:
MSGLDGGNKLPLAQTGGLAAPDHASGDPDRDQCQGLREETEATQVMANTGGGSLETVAEGGASQDPVDCGPALRVPVAGSRGGAATKAGQEDAPPSTKGLEAASAAEAADSSQKNGCQLGEPRGPAGQKALEACGAGGLGSQMIPGKKAKEVTTKKRAISAAVEKEGEAGAAMEEKKVVQKEKKVAGGVKEETRPRAPKINNCMDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFRNHPQLSPMISGQDEDMLRYMINLEVEELKHPRAGCKFKFIFQGNPYFRNEGLVKEYERRSSGRVVSLSTPIRWHRGQDPQAHIHRNREGNTIPSFFNWFSDHSLLEFDRIAEIIKGELWPNPLQYYLMGEGPRRGIRGPPRQPVESARSFRFQSG
Protein: Spore coat protein Y (Q08311)
Organism: Bacillus subtilis (strain 168)
Subcellular location: Spore coat {ECO:0000269|PubMed:8509331}. Note=Outer coat.
Interaction partners:
- Spore coat protein X
- Spore coat protein W
- Spore coat protein V
- Spore coat protein Z
- Spore coat protein G
- Spore coat protein E
- Spore coat protein B
- Spore coat protein F
- Spore coat protein S
- SpoIVD-associated factor A
Sequence:
MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPTIAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPVDVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHHNG
Protein: Follistatin-related protein 1 (Follistatin-like protein 1) (TGF-beta-inducible protein TSC-36) (Q62356)
Organism: Mus musculus (Mouse)
Function: Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- SPARC
- Disco-interacting protein 2 homolog A
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-2
Sequence:
MWKRWLALSLVTIALVHGEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSASPSASPVVCYQANRDELRRRLIQWLEAEIIPDGWFSKGSNYSEILDKYFKSFDNGDSHLDSSEFLKFVEQNETAINITTYADQENNKLLRSLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTCDGKNQKGVQTHTEEEKTGYVQELQKHQGTAEKTKKVNTKEI
Protein: FAM161 homolog famh-136 (P30629)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21611156}.
Interaction partners:
Sequence:
MSNSTMEATQMKVKLAVDEMIDDLDKTYLRDMQKSMFQCSARCCDNKKTTRDAVENCVESCNDGMKKAQGYLEKELGGLQDQLSRCAMTCYDKLVQQFGPDVNKYSESQKLSFNEKLDSCVSVCADDHIKLIPAIKKRFAKNT
Protein: Cytoplasmic linker associated protein 2 (E3W994)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAMGDDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGADPTTDVSGQS
Protein: Probable peptide chain release factor (Q9HTA0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- 3'-phosphate/5'-hydroxy nucleic acid ligase
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein bL27
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein uL16
Sequence:
MILLQLSAAQGPAECCLAVAKAFERLCLEAAQAGVEVEVIEEVAGERPRTWRSLLLGLRGTAAEALAERWCGGIQWICPSPYRARHARKNWFIGAERFAAPPASLEGEIRFETLRSSGPGGQHVNTTDSAVRATHLASGISVRVQSQRSQHANKRLAILLIARRLADQASSAADALRAERRRAHGRISRGAARRVFRGERFEPA
Protein: ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta) (P9WPU5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01347}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01347}.
Interaction partners:
- ATP synthase subunit b
- ATP synthase subunit alpha
- ATP synthase gamma chain
- ATP synthase subunit a
- ATP synthase subunit b-delta
- ATP synthase epsilon chain
- ATP synthase subunit c
- Uncharacterized protein Rv1507c
- DNA-directed RNA polymerase subunit beta
- Elongation factor Tu
Sequence:
MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFNALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEGVKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLKDTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDFDHVPEQAFFLIGGLDDLAKKAESLGAKL
Protein: Nebulin (G3UWS1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QTTALQHAKDVKDMVSEKKYKIQYEKMKDKYTPVADTPILIRAKRAYWNASDLRYKETFQKTKGRYHTVKDALDIVYHRKVTDDISKVKYKENYMSQLGIWSSIPDRPEHFHHRAVTDAVSDVKYKEDLTWLKGIGCYAYDTPDLTLAEQNKTLYSKYKYKEVFERTKSNFKYVADCPINRHFKYATQLMNERKYKSSAKMLLKQGCNEILRPDMLTALYNTHMWSQIKYRKKYEKSKDKFTSVVDTPEHLRTTKVNKQISDILYKLEYNKARPRGYTTIHDTPMLLHVRKVKDEVSDLKYKEVYQRNKSNCTIKPDAVHIKAAKDAYKVNTNLDYKKQYEA
Protein: Calcium/calmodulin-dependent protein kinase II inhibitor 1 (calcium/calmodulin-dependent protein kinase II inhibitor alpha) (mCaMKIINalpha) (Q6QWF9)
Organism: Mus musculus (Mouse)
Function: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear. Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction. Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling.
Subcellular location: Synapse {ECO:0000269|PubMed:17350603, ECO:0000269|PubMed:28642476}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic density {ECO:0000269|PubMed:17350603}.
Interaction partners:
Sequence:
MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQSKRPPKLGQIGRSKRVVIEDDRIDDVLKTMTDKAPPGV
Protein: Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) (Q8CFE6)
Organism: Mus musculus (Mouse)
Function: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta. Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17003038, ECO:0000269|PubMed:17050538}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JHE5}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (PubMed:17050538). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:17050538}.
Interaction partners:
- Sodium-coupled neutral amino acid symporter 1
- Neutral amino acid transporter B
- Large neutral amino acids transporter small subunit 1
- Serotonin N-acetyltransferase
Sequence:
MKKTEMGRFNISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIKALMNIEDTNGLWYLNGDYLVLLVSLVLILPLSLLRNLGYLGYTSGLSLLCMIFFLIVVICKKFQIPCPVEAALVANETVNGTFTQAALALAFNSTADDACRPRYFIFNSQTVYAVPILTFSFVCHPAVLPIYEELKSRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYGHVESELLHTYSEIVGTDILLLVVRLAVLVAVTLTVPVVIFPIRSSVTHLLCPTKEFSWLRHSIITVTILSFTNLLVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKEPMRSVQKIGALCFLLSGIVVMIGSMGLIVLDWVHDASAAGGH
Protein: Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11) (A0A0G2K2A7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364147}.
Interaction partners:
Sequence:
MATYSLANERLRALEDIEREIGAILQNAGTAILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKISDVARTCEQMLEN
Protein: Programmed cell death 2 (Programmed cell death protein 2) (Q1MTH6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Family with sequence similarity 120B.
- Small ribosomal subunit protein uS5
- Protein LTV1 homolog
- Zinc finger protein 277.
- RNA-binding protein PNO1
- Proteasome subunit beta type-1
- Sodium/potassium-transporting ATPase-interacting 2.
- Protein BCCIP homolog
Sequence:
MAANTLKESNTHSDVVLGFLEEAESWQLLSDQFPSKVGGRPAWLSQSDLPAVSELQCEECKLPAVFLLQVYAPVTEYDRCFHRTLFVFCCKTPACYTRNDSKCFKVFRSQLPRKNEFYPFNPPPDEKPEQPVHDAQVLGSGLKLCRLCGCLGQKACSRCHSVTYCCKEHQTTDWKQRHKKECLAEASQVSGELNSFLFPEWELVTEPEVIPAKDELQESPSLDQENIASLNSGLEDSELESMALHETLDSKVFQKFKQRIANEPQQVLRYCRGGSPLWVTAEHVPREEEVPECTCGAKRLFEFQIMPQLLNHLKVDSTDASIDWGTVAIYTCAESCDQGNKYSPEFIWKQDFSGDQAE
Protein: Histone acetyltransferase (EC 2.3.1.48) (Q7SXF3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361211}.
Interaction partners:
Sequence:
MNNSYENCGSEERMDVEIDSGHAGTDRGRLETGTRATCSSNGSGGEEDEMEAADREREATGSSTPRSADGVSLGGGREQEVSVEIGETYLCQRTDKTWHSAEVIQSRLNEQEGREEFYVHYVGFNRRLDEWVGKARLALTKTVKDAVRKSVEEGGGGELVDQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIQIGNFEIDAWYFSPFPEDYGKQPKLWICEYCLKYMKYEKTFRYHLSQCQWRQPPGKEIYRKNNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFIFYILTEVNKQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQSDIISTLQPLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDTHCLKWAPPKHKQAKFSKK
Protein: Keratinocyte-associated protein 3 (KCP-3) (Q53RY4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPPLHWVLLALALVNLLLSVACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAALSGYCCVAALTLRGVGPCRKDGLQGQLEEMTELESPKCKRQENEQLLDQNQEIRASQRSWV
Protein: Diacylglycerol acyltransferase/mycolyltransferase Ag85A (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex A) (85A) (Ag85A) (Fibronectin-binding protein A) (Fbps A) (P9WQP3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM. FbpA mediates triacylglycerol (TAG) formation with long-chain acyl-CoA as the acyl donor and 1,2-dipalmitoyl-sn-glycerol (1,2-dipalmitin) as the acyl acceptor. It has a preference for C26:0-CoA over C18:1-CoA.
Subcellular location: Secreted, cell wall. Cytoplasm.
Interaction partners:
- Diacylglycerol acyltransferase/mycolyltransferase Ag85C
- Diacylglycerol acyltransferase/mycolyltransferase Ag85B
- Triacylglycerol lipase
- Diacylglycerol kinase
- 6 kDa early secretory antigenic target
- Antitoxin VapB47
- ESAT-6-like protein EsxH
- Terminal beta-
- Immunogenic protein MPT64
- Conserved protein
Sequence:
MQLVDRVRGAVTGMSRRLVVGAVGAALVSGLVGAVGGTATAGAFSRPGLPVEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDINTPAFEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWETFLTSELPGWLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLLDPSQAMGPTLIGLAMGDAGGYKASDMWGPKEDPAWQRNDPLLNVGKLIANNTRVWVYCGNGKPSDLGGNNLPAKFLEGFVRTSNIKFQDAYNAGGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPNTGPAPQGA