wanglab/gogpt-training-data huggingface dataset:
Protein: DNA topoisomerase 3-alpha (EC 5.6.2.1) (Q9LVP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells. Together with RMI1, is essential for the resolution of meiotic recombination intermediates, a step that prevents entanglement of the parental chromosomes. May have DNA decatenation activity.
Interaction partners:
- ATP-dependent DNA helicase Q-like 4A
- AT5G19950 protein
- Crossover junction endonuclease MUS81
- ATP-dependent DNA helicase Q-like 4B
- DEAD-box ATP-dependent RNA helicase FANCM
- DNA repair endonuclease UVH1
- DNA mismatch repair protein MSH4
- RecQ-mediated genome instability protein 1
- DNA repair protein RAD51 homolog 3
- Meiotic recombination protein DMC1 homolog
Sequence:
MSRRGGGPVTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNCPSRVPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFAWEDSINNSSGNATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSATGEPVSGIRCFSCGDPSHFANACPNRNNSNGNYF
Protein: Pre-mRNA-splicing factor SPP2 (Spliceosome maturation protein SPP2) (Suppressor of PRP protein 2) (Q02521)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing; specifically in the final stages of spliceosome maturation. Promotes the first step of splicing.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2
- Pre-mRNA-splicing factor SNT309
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-splicing factor CWC26
- Pre-mRNA-splicing factor PRP21
- Pre-mRNA-splicing factor PRP9
- Pre-mRNA-splicing factor CWC22
- U2 snRNP component HSH155
Sequence:
MSKFSLKLGSKTLKKNISKKTKKKNSLQKANLFDWDDAETASLSHKPQSKIKIQSIDKFDLDEESSSKKKLVIKLSENADTKKNDAPLVEYVTEKEYNEVPVEEFGDALLRGMGWESDSEQDSKGDKTQSRNKDVSNVSQIHPDGLGIGAKLNKAINVEEASFMPVVKIDKITGTKVDDDKKNKS
Protein: MI domain-containing protein (Q583R9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- ATP-dependent RNA helicase
- KRR1 small subunit processome component
- Sas10 C-terminal domain-containing protein
- RNA cytidine acetyltransferase
- CCAAT-binding factor domain-containing protein
- ESF1 RRM domain-containing protein
- Uncharacterized protein
- U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein
- U3 small nucleolar ribonucleoprotein protein MPP10, putative
- U3 small nucleolar RNA-associated protein 18
Sequence:
MDVFSRHGNRRRPREDEMEENDYTFDRQRDRKERRRNERRAKKEMRIEAHERWVEQCRLAREQKKKRSVRVKNGSENQAATRNFSNRPLRERKVNRNAKRETSFNDAKEKSTSSQKLTMESKREAKQRDGKSVVDLAKACATTPDSTQGKYIPPSLRQKMIVQKPTNAVNEAARRIINKLTVQNVADMTRETSELFGGGVEGATRASVISSLAENMNRICLLDSGPLTPLASLPFAGLIRGLQLLHGNIVGAEVIECLAIALQQQLMDNNEAAACNGAMLLAHLYLLNAVDCVLASTFLRSVLQMGGGGSLCAAAAGLTFLRACGEKLLKEAPVEMERALNEGAPSREISQNATSRYSALLSLIKEIVAGRTRNARRSVDEEKVPLDSLLSDISTLLSGGGKTSLSSSGNKRALLRVMSTTSVLTGLSWARLIQQDKPHRWYVPETWTDTVGDGDETNDEHADDDKGGASSASGDIDERSDGDEGTVEKMEQIRLLRQQEKAISGQRLNTENKREVFKCVVNASDDLEAFTLLMHRDPSFSRLHDTFAVLLQCCYQENLYNPYYTQVVQRFCSAKPSCKNTLQFAIWDMFKTIRVEAVDVTGYLNLACLIAQLMQEGVYTLAVLRGLDLENTNRTIGLFTRILLLRLILQLPPSSLTEVFFGGNGVYAHDVKIDTSTLRENLKKVFERYFVKEEDAGKWIPHFYDVAAVGTPFDVHKQMGAVAANASGMESVDEEAQLQSFVRRIRVVYKALKGGIS
Protein: SBF complex DNA-binding subunit (A0A1D8PCM9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Transcriptional regulator
- G1/S-specific cyclin CLN3
- Transcription factor MBP1
- Cyclin-dependent kinase 1
- Protein phosphatase PP2A regulatory subunit B
- Mitogen-activated protein kinase MKC1
- Rme1p
- Bub3p
- Karyopherin
- Rlm1p
Sequence:
MSEPPQVFRATYSNTDVYECMMNESSIMRRCKDDWVNATQILKCCNFPKAKRTKILEKGVQQGLHEKVQGGFGRFQGTWIPLEDARKLAKTYGVTEELAPVLFLDFSDPNLIIPRKEKPASKEPAAAKRKYMKKAKQAGDPPRRYKTGKKAALQAAEEAAAAAAAAAAASTGTGPGNTLPITTSASRIISQLSATTPANVAIQGNSQIQTGQIHDVMSSQDTFNSISRQNSYIPPTAQQLPHMYNMSQSTPASSQQPIDNGNTLIGTSNGGFGQPEFQPVSNNNMPAYPNDIQNFQMFQRMQQQQQQQQQQQMPTQQRFFQNGSAPNPIPQQILHQGKVSSSQSSNDSNWSFSNTQKDSDTSINSTAEEPRKMQLQEPSPQADNGYAAQLLRFFSEDNVDIPYFIIYPPADFNINEPIDDEGHTPLHWAASIGNFEMIHLLLSKGANPLVVNNFGLNPLSKLISFNNCFELKNFPTVLDDLELCLINTDINGRTPLHYLCQFAKSKTKNDSLVYYLKVILNKLTILSNQSQVRQINLMKNVLDHQDVHGDTCLHIAVRSGNIDIVKILLQYGAMDDLENINRETARQLITQCNLIPNYTQVDAAQVAYQNQMQLGMGDYSNYNVNNNAMNQNHNESSHNVPIVPGLATPIQSTFTKVETPDTQRTTVQEDDMDDDNESVVARVDKKHLEALTDNKENIFTEKHFDNISTPINKKHNPINSHHPLAVISEVEITTSNSVSETPMPLPEGKNQRKQQQETPLPLPLSLPKQQQDEREVSGDESTPHFYHPHPPKLNDEGKIEDTEDNVEPKLPMSDLSSMISGMINSLSHTYTSDSAKLDLEIFKLKESINLKQQENQESLTRVQKLLINSGIQESQIESIEQGQELIIETIEVCERTIKEKEQELLKVLQHNQSIELAKLVEQHESRYLEEDKKNHYENSHNRDDDLIDQSRIDDAIELSKLQLERNRLVNEIVLHTKSFGIDEKMYKYRKLLSLSCGVKVEEIDSLIDGIAESLTEGMT
Protein: Histamine H3 receptor (Histamine receptor H3) (Q6ZM33)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Histidine decarboxylase.
Sequence:
MQSSLLSVAHSPGIPTAVSLMWKSGNHQSSNWSGMERENATSLADLDTFENRRAQYGQFSPSTSIFLTVLMTLLVFATVLGNALVILAFVVEKSLRTQGNFFFLNLAIADFLVGGFCIPVYIPYVLTGEWRLGRGLCKLWLVVDYMLCTASVFNIVLISFDRFQSVTKAVSYRCQKGITKDAVLKMLCVWLAAFLLYGPAIISWEHITGGSVVPDGECYAEFYFNWYFLMTASTVEFFTPFISVTYFNLSIYINIRNRCAMREEQPTYVRLRSFKMKPLGAGDVQRVFFVRPVEESRVADLASRSRCCRLASTAKVSAAEFGNGRQSKRRDSTLADLPPLQVEERILAASEAQFHYVDHSAGPHRHRPDMVASLANRFRLSRDKKVAKSLAVIVCVFGLCWAPYTLLMIIRAACHGQCVQHYLYEISFWLLWINSSINPILYPLCHSSFKRAFSKLLCPSKTKIQPQNIDQKY
Protein: Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 12) (J3QSD7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASST
Protein: PDZ domain-containing protein (G5ECZ8)
Organism: Caenorhabditis elegans
Interaction partners:
- MAGUK p55 subfamily member 5
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- ULP_PROTEASE domain-containing protein
- Abnormal pharyngeal pumping eat-20
- DH domain-containing protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- MAGUK family
Sequence:
MIDEPEDIIAVEDEAERRCSTGSTRGLWPMPLQSEEERIREVLRELKSRKEGGDVKEDIERIERILKDPLFKQLSHQPTSSPETFKSDNRRNSAAEKRVVEISKRIESSEIRKNLKQNQKLLFIYVDAKLVDPVVLETKEKSSRLLVVGPKDVKNRSTGKLRIGDCVVAIDASGGSSVPSAPSSTVSSDDTKGAAATTTARFAIHNQTIGKSEFETACHKSISAKQHLVVGVIREATPMVLSGDWTQVEVIHLNTETGGLGFGIVGGTSTGVVVKTILPGSPADKDGRLQPGDHILQIGNINSHGMSSQQVATILRHQHPTVDMIVGRPIAYADKPIDTPECFTLATKAALCATTLEEALQRQMATSVPSTTANQTPNTLSPSISCVPIEEEKEEKEPEPEPTTSKEQPIKITTYLPDTIDIRKPCDCAPNYNRRDKRKSSCDDGEHGDGDGGGGCKKTKEDHQEEENEIDSKDELGEMVRSPTVETGQSDENSVVTSVSRSSKRNSNSITSRISLKSLQEMALTVFLRENWESTKFELIDVALHRDPALGLGITVAGYVHKKEEIGGIFVKSLVPRSAASSSGVIKVHDLILEVNGTTLEHMSHADSVRTLVKSGDQVKLKLVRFPLSSPQAQCLKMLQQQETETQVIDVKLSNPDLVKEWKSRIGDDIEIIAAVVKPDRQSVDGGLGISLEGTVDVLNGAQLCPHHYIESIRQDGPVAKTKVLQAGDELLQVNHSPLYGESHVTVRQALTRAVHSGAPVTLIVARRSQHLHVFEPTTYEKQLPLSFPFLAANQETVVKAKSDIDLTSTRAETTHLLQRVSRRLRSKSLENFHGLAVWNCVPLVIHLCKDSRGLGFSIVDYKDPTHRDESVIVVQSLVPGGVAQADGRVVPGDRLLFVNNHDLSNSSLERAVAVLKAARMGPVRLGLAKPIPVDQSQFTSHSPLCSRSERLLARGRSPRGRRRYTSGTTSSQETVWIGTAEQYRKLHPQGYYPSRSPSAARSERSIEGSEFSMTSWSPCSTRSVSPCGSPISLRGSWAYDVVFLPTHLERTVKLQKGALPLGAVLDGDKDKGVNGCVVKSICGKKAVALDGRIQVGDFITKINTESLRNVTNSQARAILKRTNLVGTFCNVTYITSADAKTWKERFQRPSESSSPIINRLSPKVFPKFYRSPFMQRQESQSKTEMTDDETEAPSIMTDSMSEHIKTFDLAEGSSRSHHDEQEVRNRMSRLIDGVEVDDFVNLIIKEAITDATIELRVLHKTKDWSNCNHKREERLESPPLPPPPPEVLSSPPKSPVASVQPTPRDLEEVLTRSTASSLEYHSGQRTSQLHILSTEEEVLQATPPSSPENKSSEVPPSISPSGIKLAGEVTAPEEIEVVKEQAENVDRAETAATGAEVEATSTPTAEAIGNSKDDESTTTSISQQSVGLQTQALNSTEVNSNMSRVTSRTPSTGSESLQNQARQLVRSKYWGEARTVTLVREPNKSFGISIVGGRVEVSQKGGLPGTGNTVCGIFIKSVLPNSPAGRSGQMNMGDRVISVNDVDLRDATHEQAVNAIKNASNPVRFVLQSLHTNQQNMINSASNSTVGSVRFENAKPEEELPPTALVTPLKPMISSSGSSTSKPAMNFPPPSISTTTTTSMESESKEEEATSSSPDIQRENTVKRRSMDVEREQPEANPVEETSIVKEKTPPRKISAKSNSSQKESNDRKEIKKQKSVEREMSVESKKSVRSIKKHRQESTIIKKSPSNETAPLIVSDVSSSETHEDEPQAMSPSTSFDTRDADAMRALGIDDDSAAFQIKNDGEEPSKFFYTAGKIERKYDSDGGELVLVACERPDGGLGISLAGNKDRDKQNVFVVNVRPSCPLAIRPGDELLEINGRLLNKISHVAASAVVRECCDQHQNIEIVLRRRNGALNECAVRSDTITSSQSLPSPPTSPSTLAPSESKSTAPQMPTTTEGIENAAPNQEELSRKKSFSQERTQAIENGRETMIEIDKDGKGLGLSIVGGADTVLGTVVIHEVYSDGAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETANRVHAATQALAKSATTPRTTENNNDPVRPVAVAVSSPAATPSTSASVTVTSAPATSVPEPNVVVEPIPGPTSAREERNDVPPPAPPMRPIITHTSPEGCETQQEPAGLSPVTEEPSSGCDFMSVQEEEQPRTPTTTTSSSNNNNSLAIDIIHDLKEEGSDTLLVELKKVVDQQLGMGIGKRSRGILVTSLQPGSAAAEKLKVGDRILAVNALPVSDQLSAVTFVKASGQRLYLQIARPHSIPQQ
Protein: Mitochondrial thiamine pyrophosphate carrier 1 (Q59NH3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSKQIEKKPISFANIALGAGLNLAEVTTLGQPLEVIKTTMAANRSLTMPQAAKFVWSRGGILGFYQGLIPWAWIEASTKGAVLLFVSAEAEYQFKKLGMNNFVSGMGGGITGGLAQAYLTMGFCTCMKTVEITRSKQANTPGVPQQTSFQVFKEIYRKEGIRGINKGVNAVAIRQMTNWGSRFGFSRLAEESIRSLTGKSESQKLSAWEKIASSVIGGGLSAWNQPIEVIRVEMQSKTNDPNRPKNLSVAGAFKYIYQQNGIKGLYRGVTPRIGLGVWQTVFMVAFGDIFKRMLNTDGTGH
Protein: Uncharacterized protein (Q581S2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MALHAAHRRALYLHHAKHLSQYSDAHDYYRLMMWCHDQHIFIHPTVRIHRRPSPYRDHAFVVTEDVDRLTPLFAIPEALAIGFKDTSEAENNLRDEEREKEFNKLNTGEQSDADICQFFFDSLGMIVSDLITSIGSPLTDPRWAFAELLGRVRSMKNAPYFEDDVVLDAEATGLADVLLQMIRNYINGGPLVGKVDRAQLRWAVSTCLSHSTPLVIGATRSIGIIPMVHLFPHGGKNTNSLVVARTSQQSSATRMAAYFARHHQYDFMCEQDGKWIYVVPARALRAGEEICMQTMAPVCGKDSEAEKMWRLSCGTPPEDYVPSAAVAHQQDIITNELIRKGEQIISTEYGK
Protein: Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) (P9WFT3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00140}.
Interaction partners:
- Probable conserved integral membrane protein
- Phenylalanine--tRNA ligase beta subunit
- Leucine--tRNA ligase
- Tryptophan synthase alpha chain
- Serine--tRNA ligase
- Indole-3-glycerol phosphate synthase
- Arginine--tRNA ligase
- Isoleucine--tRNA ligase
- Valine--tRNA ligase
- 2-isopropylmalate synthase
Sequence:
MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGFLL
Protein: pEARLI1-like lipid transfer protein 1 (Protein AZELAIC ACID INDUCED 1) (Q9SU35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable lipid transfer protein (LTP). Seems to control the flowering process and lignin synthesis. Together with DIR1, required for glycerol-3-phosphate- (G3P) and azelaic acid- (AA) induced systemic acquired resistance (SAR). Component of plant systemic immunity involved in priming defenses in a AA-dependent manner, by modulating production and/or translocation of a mobile signal(s) during SAR. Confers resistance to Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 and PmaDG3. May be involved in induced systemic resistance (ISR) mediated by non-pathogenic bacteria (e.g. P. fluorescens GM30). Prevents electrolyte leakage during freezing damage.
Subcellular location: Secreted, cell wall {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23602565, ECO:0000269|PubMed:27078071}. Cell junction, plasmodesma {ECO:0000269|PubMed:23602565}. Plastid, chloroplast {ECO:0000269|PubMed:27078071}. Note=Chloroplast location is observed in the absence of PLDP1 or PDLP5. {ECO:0000269|PubMed:27078071}.
Interaction partners:
- Dirigent protein 11
- Glycerol-3-phosphate dehydrogenase [NAD
- Proline iminopeptidase
- Putative lipid-transfer protein DIR1
- At5g15780
- Dirigent protein 1
- Mitogen-activated protein kinase 3
- Cysteine/Histidine-rich C1 domain family protein
- Uncharacterized protein AT4g12540
- Methionine gamma-lyase
Sequence:
MASKNSASLALFFALNILFFTLTVATNCNCKPSPKPKPVPSPKPKPVQCPPPPRPSVPSPNPRPVTPPRTPGSSGNSCPIDALKLGVCANVLSSLLNIQLGQPSSQQCCSLIQGLVDVDAAICLCTALRANVLGINLNVPISLSVLLNVCNRKLPSGFQCA
Protein: Putative N-terminal acetyltransferase 2 (EC 2.3.1.-) (Amino-terminal, alpha-amino, acetyltransferase 2) (P37293)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Maybe involved in N-terminal acetylation of proteins. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YFR012W-A
- Protein DCV1
- Uncharacterized protein YGR146C-A
- Sporulation-specific protein 77
- mRNA-binding protein PUF3
Sequence:
MMVPRISASPVFKRIFLRWGFVTLPIQKTVSHTLRRDFSAPCRSMVKCLLLRPGISVHSAQDRKFYSTEEKSSQFDENKSKSNNGKKNEPHGIKGLMAKYGYSALIVYILLTCVDLPLCFLGVHSLGEEKIKIYLNRGKQLIGMGEPDESKVIQDVRRKQAHREAVQAENADKVEDASRKTFNERWQEMKDSTLLAELLIAYGIHKSLIIVRVPLTAVLTPSFVKLLQRFGIDLMKKQKKVFQTMASGAKIRYKGNNPSDFIKNEGTALDITKRKPRTKGQKWFDGLM
Protein: Squamosa promoter-binding-like protein 4 (Q9S7A9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3' of AP1 promoter. Promotes both vegetative phase change and flowering.
Subcellular location: Nucleus {ECO:0000269|PubMed:16095614}. Cytoplasm {ECO:0000269|PubMed:16095614}. Note=Mostly located in nucleus.
Interaction partners:
- Agamous-like MADS-box protein AGL8
- MADS-box protein SOC1
- Protein LEAFY
- AP2-like ethylene-responsive transcription factor SMZ
- Protein TWIN SISTER of FT
- AP2-like ethylene-responsive transcription factor SNZ
Sequence:
MEGKRSQGQGYMKKKSYLVEEDMETDTDEEEEVGRDRVRGSRGSINRGGSLRLCQVDRCTADMKEAKLYHRRHKVCEVHAKASSVFLSGLNQRFCQQCSRFHDLQEFDEAKRSCRRRLAGHNERRRKSSGESTYGEGSGRRGINGQVVMQNQERSRVEMTLPMPNSSFKRPQIR
Protein: Probable macrolide-transport ATP-binding protein ABC transporter (O53164)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible transcriptional regulatory protein
- Probable enoyl-CoA hydratase EchA12
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL13
Sequence:
MITATDLEVRAGARILLAPDGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGEVEPYAGSVTRAGEIGYLPQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLSGGQRRRVELARILFAASESGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVISHNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDEQRRIRERANAERKAAALRAQAAKLGAKATKAVAAQNMLRRADRMMAALDEERVADKVARIKFPTPAACGRTPLVANGLGKTYGSLEVFTGVDLAIDRGSRVVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDNDATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGPQRVVLLPDGTEDYWSDEYRDLIELA
Protein: Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) (B9WI58)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Interaction partners:
Sequence:
MGANASILDGFIEDTNFSIEEIDRLRKRFMKLDKDGSGQIDKQEFLSIPGISSNPLATRLMDVFDKDGDGSIDFEEFITGLSAFSGKSDNLNKLRFAFNIYDIDRDGYIGNGELFIVMKMMVGKNLKDEELQQIVDKTLMEADLDGDGKLNFEEFKNAVNTDTIANTLTLNMF
Protein: IspC (A3RI35)
Organism: Listeria monocytogenes
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MINKKWMKIVMIPMLVVPMYGLTTVGGQLQDSLTGENSFVKEVEAATTASQQAFIDKIAPAAQASQEKYHLLSSITLAQAILESGWGKSGLATQGYNLFGIKGKYNGQSVIMTTSEYVNGEWIKIDAEFRKYPSWNESVTDHTLLLVNGTSWNKDLYKKVVDATDYKVTAMEPQKAGYATSPTYGASLIQVIENYDLAKYDVLYDKILTQKSTSGKATVTSPTGNGVWTLPYKVKGVQSVSPASTYANKDIDLVSVATTKRGTYYQFKYNGKVVGWVDGKALTIYDSVNYDKVNVGRAKITSPVSNGIWSKPYNVYGREFVTNATTYAQQEIKLLREAQTAKGTYYQFSINNKTIGWIDKRALTIYPYDSIISSKNVNLDGQITNPTGNGIWTKAYKLEGTTSVAQATKYANKDVKISQQIETQHGTYYNISIDGKAIGWLDRNAITLYDQEEYNKTVAIDAVVKNVKGNAVWTEPYRTVGTKLIGPAETYLNKEVEVVREAKTPKGTYYQFKSGGKVIGWLDKKAFDVYDNINYNKAVNLDAVVENVTGNAVWTAPYKSKGVKLVTSAATYKGKATKITREAQTSRGTYYEFSVDGKVIGWLDKKAFDVYDNINYNKAVNLDAVVENVTGNAVWTAPYKSKGVKLVTSAATYKDKATKITREAQTSRGTYYEFSVNGKVIGWLDKKAFDVYDSIEYNKAINMTGLLSNAPGNGIWTEPYRVIGTKNVGQATAYANKTVQLIREAKTTRATYYQMSVNGKIVGWVDKRAFTNVK
Protein: Trinucleotide repeat-containing gene 6C protein (Q9HCJ0)
Organism: Homo sapiens (Human)
Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Interaction partners:
- Polyadenylate-binding protein 1
- Protein argonaute-2
- Protein argonaute-1
- Protein argonaute-3
- GRB10-interacting GYF protein 1
- Protein argonaute-4
- CCR4-NOT transcription complex subunit 1
- PAN2-PAN3 deadenylation complex catalytic subunit PAN2
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 7
Sequence:
MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTISSSNNGKRASASGQQPAASRYLPREVPPRFRQQEQKQLLKRGQPLPTGTLTSVSPTQGAGPAGVSPPPLPGAGTQHHPSKLQPDLSHSGLADHYENSHWGQQPTYRSEANCSWDKVIIDRTDKEAWPSITGTETESASECTTDTDSASNCGSENSSMATGSAQGNFTGHTKKTNGNNGTNGALVQSPSNQSALGAGGANSNGSAARVWGVATGSSSGLAHCSVSGGDGKMDTMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQNMGNQNGNPTGTLGAWGNLLPQESTEPQTSTSQNVSFSAQPQNLNTDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAKQNGSSSAVQKEGSGGNAWDSGPPAGPGILAWGRGSGNNGVGNIHSGAWGHPSRSTSNGVNGEWGKPPNQHSNSDINGKGSTGWESPSVTSQNPTVQPGGEHMNSWAKAASSGTTASEGSSDGSGNHNEGSTGREGTGEGRRRDKGIIDQGHIQLPRNDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQASNSGGKNDGSIMNSTNTSSVSGWVNAPPAAVPANTGWGDSNNKAPSGPGVWGDSISSTAVSTAAAAKSGHAWSGAANQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNGSGWDADSNRSGSGWNDTTRSGNSGWGNSTNTKANPGTNWGETLKPGPQQNWASKPQDNNVSNWGGAASVKQTGTGWIGGPVPVKQKDSSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPVIQSSTTTNTTTTTTTTTSNTTHRVETPPPHQAGTQLNRSPLLGPVSSGWGEMPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDHNGMAAKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSSRQIPSGNLGMFGNSGAAQARTMQQPPQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVAGKLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLTNPKPSSTWGASPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASSQPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIGSPTPLTTLLPGDLLSGESL