wanglab/gogpt-training-data huggingface dataset:
Protein: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) (O01795)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Dual oxidase maturation factor 1
- Dual oxidase 1
Sequence:
MAAENFYNVNNFQSLPLEIKVQFSKETLFSALQQEAETQRYDGWYNNLANSEWGSAGSRLHRDARSYYSDGVYSVNNSLPSARELSDILFKGESGIPNTRGCTTLLAFFSQVVAYEIMQSNGVSCPLETLKIQVPLCDNVFDNECEGKTTIPFYRAKYDKATGNGLNSPREQINERTSWIDGSFIYGTTQPWVSALRSFKQGRLAEGVPGYPPLNNPHIPLNNPAPPQVHRLMSPDRLFMLGDSRVNENPGLLSFGLILFRWHNYNANQIYREHPDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGEDVRLSNYTKYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKCEFRTEVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQIAERDDNIVVEDLRDYIFGPMHFSRLDVVASSIMRGRDNGVPPYNELRRTFGLAPKTWETMNEDFYKKHTAKVEKLKELYGGNILYLDAYVGGMLEGGENGPGEMFKEIIKDQFTRIRDGDRFWFENKLNRLFTDEEVQMIHSITLRDIIKATTDIDETMLQKDVFFFKEGDPCPQPFQVNTIGLEPCAPLIQSTYWDDNDTTYIYTLIGLACIPLICYSIGHYMVERRIRIGHNSACDSLTTDFSTESPKVNVYKVNALEWLQEEYIRQVRIEIENTTLTVKKPRGGILRKIRFETGQKIEVFHSIPNPSAMHGPFVLLSQKNNHHLVIRLSSDRDLSKFLDQIRQAASGINAEVIIKDEENSILLSQAITKERRQDRLDLFFREAYAKAFNDSELQDSETSFDSSNDDILNETISREELASAMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREFVNAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTAGVHITESVQLRLFNDVLHKSGVSDDAEYLTCNNFDALFSEISDVQPIGLPFNRKNYNSHIKEPSCHTSFPIVDHSTPAPLSLIQRICAFLETYRQHVFIIFCFVAINIVLFFELFWHSRYLNEDRDLRRVMGAGIAITLSSAGALSFCMALILLTVCRNIITLLRETVIAQYIPFDSAIAFHKIVALFTLFWSTLHTIGHCVNFYHVGTQSDRGLACLFQETFFGSDVVPTLSYWFYGTITGLTGIGLVIVMSIIYVFALPKFTRRAYHAFRLTHLLNIGFYALTILHGLPSLFGSPKFGYYVVGPIVLFVIDRIIGLMQYYKSLDIAHAEILPSDIIYIEYRRPREFEYKSGQWITVSSPSISCTFNESHAFSIASSPQDENMKLYIKAVGPWTWKLRSELIRSLNTGSPFPLIHMKGPYGDGNQEWMNYEVAIMVGAGIGVTPYASTLVDLVQKTSSDSFHRVRCRKVYFLWVCSSHKNFEWFVDMLKNVENQAKPGILETHIFVTQMFHKFDLRTTMLYICEKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSEIGVFSCGPVNLNESIAEGCADANRQRDAPSFAHRFETF
Protein: GATA transcription factor 26 (F4JP80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MIRTNGLGNKDMILGSEFVFMIRNCYTPLWRNGPPEKPVLCNACGSRWRTKGTLVNYTPLHARADGDENDDHHRFQRMKSISLGNKNKEIKMLKRKAIQENIIIKRPVFEFSYGLKAAVIEEDASNRSSSGSAVSNSESCAQFSSADGSELTGPSQSNAWDTTVPCKRRTCVGRPKSSSVEKLTKDLYNILQEQQSSCLSVSSEEDLLFENEMSMVSVEIGHGSVLMKNPHSFAREEESEASSLSSIENKSSISDAYSHSVKRVEIGAVRGSYYGGQTIKQEQFKRTKSQTERVHVLGSHGSPLCSIDLKDVFNFDEFIEQFTEEEQKKLMNLLPQIDSDDLPHSLRMMFESAQFKDNFSLFQQLIADGVFDVSSSSGAKLEEIRTFKKLALTDFNKSRLVESYNLLKEREKGTGDSVTTTSKSSIPNVPKNIVTIKRRYENQIQVKSESRGLMRSPKRVMKMKASHETENNVSCFRPRSLASVFAQEGGSAVFSYEGNCSSDQDLLLLDLPSNGSFPQAELLHQL
Protein: 5'-deoxynucleotidase YGK1 (EC 3.1.3.89) (P53144)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Interaction partners:
- Small ribosomal subunit protein eS21B
- Vacuolar membrane protein YNL058C
Sequence:
MTAVNIWKPEDNIPREILAILSKPHPNYQLAFLNIIQLLKTQRRTGWVDHGIDPCESISDHMYRMGLTTMLITDKNVDRNKCIRIALVHDFAESLVGDITPNDPMTKEEKHRREFETVKYLCESIIRPCSESASREILDDWLAYEKQTCLEGRYVKDIDKYEMLVQCFEYEQKYNGKKDLKQFLGAINDIKTDEVKKWTQSLLEDRQAFFDSLKE
Protein: Protein CONSERVED IN THE GREEN LINEAGE AND DIATOMS 27, chloroplastic (Q9FN15)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for growth in low iron conditions.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- At2g42750/F7D19.25
- Uncharacterized protein
- AT3g24470/MXP5_4
- Oligopeptide transporter 3
- Ankyrin repeat/KH domain protein
- F-box protein At3g03040
- AT5g05250/K18I23_5
- At1g12030
- thiohydroximate-O-sulfate sulfate/sulfur-lyase
- Amino acid transporter AVT6B
Sequence:
MLRLIVNYPLIPKISHRVCSNSSSKLGSYYDSSSIIKYGGISDVVGKKQELFLSVSVKAVEDKGNNGGGSMSFSGQSWDPSSEIEVPSDQRPVNEYSSLKEGMLYSWGELGPSEFFIRLGGLWLVTFTVLGVPVAAASFNPSREPLRFILAAGTGTLFLVSLIVLRIYLGWSYVGDRLLSAVIPYEESGWYDGQMWVKPPEVLARDRLLGSYKVKPVIKMLKQTLIGTGALLVSAFVLFVFATPVEDFFKTTLGSTENQPEVSISRTSNKFNIRKEQLLRLPVDVVTDDDLAAAAAEAADGRPVYCRDRYYRALAGGQYCKWEDLVK
Protein: LOBE (Proline-rich Akt substrate 40 kDa) (RE53130p) (Q7JXA2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Stress-activated map kinase-interacting protein 1
- Raptor, isoform B
- Protein LST8 homolog
- Serine/threonine-protein kinase mTor
- FI03615p
- RAC serine/threonine-protein kinase
- GTP-binding protein Rheb homolog
- GH04846p
- Ribosomal protein S6 kinase
- Gigas, isoform A
Sequence:
MLISCKCSNFVASTSKLQRSNSSSGAGGRVGGAEVASGEVPTAILLSQVFQQKYPLDFVFYSHIMEFFKHAYGPIPDLTVAVINQRELLYGLTLEAAGQSWQLSLCINCKEVLCAKRLTAGAGATPTLYLINCTLLTSSEELAQRKSNKAFSETFELLIMDHTGSDSGSTRPTSGLSNSASSLSIGSLSSNPTDARVQRLRMIQAHQQARLQEEIVETNERIERYTRTQFQLLNSFREKSDQDCALLFKVIRALPEQASELLDRAMLPALDVAANQPQSATARRRNTISSRRELNGGPTTPTTTLTHPPNFLSLNQQPQQQLLAQQQQQQLQAQQQQQQQAPQSVSMARKMSHFDTPPATPEATPMSVGNSPTFRQQSAAGGAGGPPTQTLTPNGVGQSSVNEDADDCLFDLEDVDAPVPVQSVPVPSYTRSLIYQQQPQHNPFQQLSQQNGLRSVLDDEAADEAEDALDPDSSISIPVRGGGRPSHAQLMNFARSLPIEIANTTLAERAAVANNNNFGQGCEEGMDNIDIAASIQALTRSVHGEAVFGDLPRPRLRSQIEG
Protein: Ino eighty subunit 4 (Q08561)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ino eighty subunit 1
- Actin-related protein 4
- Ino eighty subunit 3
- Actin
- Transcription initiation factor TFIID subunit 14
- Chromatin-remodeling ATPase INO80
- Actin-like protein ARP8
- Ino eighty subunit 5
- Non-histone protein 10
- RuvB-like protein 1
Sequence:
MSQESSVLSESQEQLANNPKIEDTSPPSANSRDNSKPVLPWDYKNKAIEIKSFSGYKVNFTGWIRRDVREERQRGSEFTASDVKGSDDKATRKKEPADEDPEVKQLEKEGEDGLDS
Protein: Lens fiber membrane intrinsic protein (MP17) (MP18) (MP19) (MP20) (P54825)
Organism: Rattus norvegicus (Rat)
Function: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- V-type proton ATPase subunit D
- Consortin, connexin sorting protein
- Vacuolar proton pump subunit B
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase subunit E 1
- ATPase H+ transporting V1 subunit E2
- V-type proton ATPase subunit
- V-type proton ATPase subunit d 2
- V-ATPase 14 kDa subunit
- V-type proton ATPase 21 kDa proteolipid subunit c''
Sequence:
MYSFMGGGLFCAWVGTILLVVATATDHWMQYRLSGSFAHQGLWRYCLGNKCFLQTESIAYWNATRAFMILSALCATSGIIMGVLAFAQQSTFTRLSRPFSAGIMFFASTLFVLLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVALLMTFFAGIFYMCAYRMHECRRLSTPR
Protein: Ecdysone-induced protein 93F, isoform A (GH10557p) (Q9VD60)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
Sequence:
MHISSYEISLERVAEECMGRRQWKHYQDKLTCSHLNIEEQQPIAIAGSEDEPSQYNHSSKEISQSNPNHCKTENHRLEQQHNGSQLLEEEDSENNQTSHDSSRTPTPGATSTPSPPPEPIDWRPSAKCNFCVNGRLLTVNAQGKLVAESAATATSSSTSNSHIHQHDSDSNSSASLPHHISSSSSSNNNSSGNRARHIAAASARATPAAATPANSLELYKLLTQRAAKMTSMDSMAAQLAQFSLLADFNLINSLASQQQQQQQQQIASAVTPTTSEVSAAAISPALKDTPSPSVDAPLDLSSKPSPNSSISGDVKSVRACATPTPSGRRAYSEEDLSRALQDVVANKLDARKSASQHHEQRSILDNRLFKMKHHDQEQDHDGDELEDSNDDAEAEVDSNASTPVYPAEFARAQLRKLSHLSEHNGSDLGEDVDRGSPKMGRHPACGNASANQGAPPSIPLDANVLLHTLMLAAGIGAMPKLDETQTVGDFIKGLLVANSGGIMNEGLLNLLSASQENSNGNASLLLQQQQHQQHHQQHHQQQQQQQHVAAYRHRLPKSETPETNSSLDPNDASEDPILKIPSFKVSGPASSSSLSPGGLVGGHHHPLNNNNSLSISNNSNHSSNSHRNGSNRSPHSASPMLAAAVAQGGYSAGNSLLTSSSSSIQKMMASNIQRQINEQSGQESLRNGNVSDCSSNNGGSSSLGYKKPSISVAKIIGGTDTSRFGASPNLLSQQHHSAHHLTHQQQQQQLSAQEALGKGTRPKRGKYRNYDRDSLVEAVKAVQRGEMSVHRAGSYYGVPHSTLEYKVKERHLMRPRKREPKPQPDLVGLTGPANKLQLDKLKAGPHGGSKLSNALKNQNNQAAAAAAAAAAAAAAATPNGLKLPLFEAGPQALSFQPNMFWPQTNATNAYGLDFNRITEAMRNPQASNHHGLMKSAQDMVENVYDGIIRKTLQASEGNGSAAGNGSNGSNGNGHGHGHGHGHALLDQLLVKKTPLPFTNHRNNDYAATCSSASGESVKRSGSPMGNYADIKRERLSADSGGSSDEEHSASHINNNNSDLAHNKNKSGGGGGGGGNGQTNGNGRSSRMTSRDDSETDASSLKSGESGGQQNHKMMDLNGGSSSSSHIKCESEAATGHHSPGHHTTSILHEKLAQIKAEQVDQADQL
Protein: Transmembrane protein 247 (Q497K7)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Proline rich 22
Sequence:
MAMEDREVMEARGAGESCPTLSKVAPVDSMPEGKPKASLDAEVPKLELPTLEENGICEDRDCPGPPRSLPPKSGPNAKGQAGDGPGLESVELPLPLETEHRNAMELEKVRMEFELTLLKYLHQENERQRQHEEVMEQLQQQQQQQQALPHQFSGSLQDLLLPQNQFAMFFYCFIFIHIIYVAKETVFFLFSKHYLFCLAAILLCLIKTLWS
Protein: Arhgef7b protein (Rho guanine nucleotide exchange factor (GEF) 7b) (Rho guanine nucleotide exchange factor 7b) (Q5PRA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}.
Interaction partners:
Sequence:
MNSAEQTITWLITLGVLESPKKTLSDPEGFLQASLRDGVVLCKLLERLRPGSVHTIYQDPRKDECLSNIREFVKGCALYHIEVFEANDLLQGQNFSKVLNCLVALNKATSESGGGSNSVCSRQSSSLRIKSFDSLNCSSTHRRSSRHKFNQYRSLDMSENSAPQVLVKARFNFQQTNEDELSFSKGDIIQVTRQEEGGWWEGALNGKTGWFPSNYVKETKGSDKPVSPKTGTLKSPPKAIESANFCKTYYNVVVQNILQTETEYCKELQNLLSVYLRALQPTDRLSVSDISHIMGNLEEISSFQQTLVHSLEENVKVSDSQQRIGGFFLSLLTQMRSLYVTYCSNHPSAVNVLTQHSEELGEFMESKGANTPGILTLTTGLSKPFLRLEKYPTLLKEMERHMEPLHPDYPDIQKSMTLFKNLSAQCQEVRKRKELELQILMESIRGWEGEGIKTLGTVLFMSQVIIQNHGAEEKNERYLLLFPHILLMLSASPRMSGFIYQGKLPLTGMSVSKTEDSDGTKHAFEISGNMIERIQVICNNQQDLQDWVDHLHRQTKRISTSSLKPQSVPCHTLPSHPLTPSRHSESRGVSGSPVYHTLPHLSSLGTPHSGMMWGPLEPPKTQKPWSLSCLRPAPPLKPSAALCYKEDLSKSPKNMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSRSRKESGPHMLFPEEEKIIVEETKSNGQTVIEERSLVDTVYALRDEVQELKQDNKRIKRTLEEEQKARKELEKVVRRVLKSMNDPSWDETNL
Protein: Cytochrome P450 3A9 (EC 1.14.14.1) (3AH15) (CYPIIIA9) (Cytochrome P450 olfactive 3) (Cytochrome P450-OLF3) (P51538)
Organism: Rattus norvegicus (Rat)
Function: This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 1A2
- Cytochrome P450 2E1
- Cytochrome P450 1A1
- Cytochrome P450, family 2, subfamily j, polypeptide 4
- Cytochrome P450 4A12
- Aromatase
- Cytochrome P450 4A10
- Cytochrome P450 26A1
- unspecific monooxygenase
- Cytochrome P450 4A2
Sequence:
MDLIPNFSMETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGFWEFDKYCHKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA
Protein: AAA-ATPase ASD, mitochondrial (EC 3.6.1.-) (AAA-ATPase 1) (Protein ATPASE-IN-SEED-DEVELOPMENT) (Q9FLD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required to regulate morphology and anatomy during seed maturation.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:21359673}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Hypersensitive-induced response protein 1
- D111/G-patch domain-containing protein
- Remorin family protein
- Putative NAC domain-containing protein 94
- Aspartic proteinase 39
- Remorin family protein
- Protein LIFEGUARD 3
- Protein LIFEGUARD 1
- Receptor-like protein 11
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
Sequence:
MVKMGEVWTNTGSALASLVFIYTIFERFFPYRLREHFEPLAQSLIGFIYPYIQITFHEYSGERFKRSDVYDAIQSYLSKDSSSRAKKLTANTIKGNKSIILSMDDHEEITDEFQGVKVWWQSKKHQSESRAISFYPKADESRFYMLKFHRRDREVITKKYLNHVISEGKTIEVKNRERKLYSNNPSQNWSGYKQTKWSHVTFEHPATFDTLAMEYKKKEEIKNDLIKFSNSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANLLEYDVYDLELTTVKDNTELRRLLIETSGKSIIVIEDIDCSLDLTGQRKQKKDEEEDEDETSPIEKQMKKDQGENKGSKVTLSGLLNFIDGLWSACGGERIIVFTTNFIDKLDPALIRKGRMDKHIEMSYCGFEAFKVLANNYLDAKEEDDNELFDEIKRLLEVEEIKMTPADVGENLLKKSEVETKEICLKRLIEALKEEKEEAKRRIEDEEKKKKEEEEIKRKKREEKKIKKEEKEEKEENETTMKD
Protein: Agamous-like MADS-box protein AGL11 (Agamous like-protein 11) (VvAGL11) (MADS-box protein 5) (VvMADS5) (Protein SEED DEVELOPMENT INHIBITOR) (VvAG3) (VviAG3) (F6I457)
Organism: Vitis vinifera (Grape)
Function: Probable transcription factor involved in seed development. Plays a role in seed morphogenesis by promoting the correct development of endotesta cell layer, which directs the further development of the seed coat, the endosperm, and consequently the embryo.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
Sequence:
MGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSSRGRVYEYSNNNIKSTIDRYKKASSDSTNGGSTMEINAQYYQQESAKLRQQIQMLQNSNRHLMGDSLASLTVKELKQLENRLERGITRIRSKKHELLLAEIEYLQKREIELENESVYLRTKIAEVERLQQANMVSTHEFNAIQALVSRNFFQPNMIEGGSTGYPLPDKKVLHLG
Protein: Chromatin binding protein, putative (Q384Z2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEERVSCVTENTPEPTEAATSTVIAVCGCGNDGRLGIGISDTQYKVVLIPFFLGSADSDGRPLGNIRTVRVGGYHNFVITTEGVYGWGLNENGQLGMGRGSPACVSVPTRIPFFDGKNTKDIVCGAYHTFAWTEDGLYACGKNEDGQLGLPCDDGLFSFTLVLSALQVNGDASNTADQCGGREDAAGAYDLLKRGQLTHVSCGTHHTLLALRDATLATGEADDSVAQHRSHPLLVLAAGKGDFGELGYDGDMWSILQAKAKTMQSALQNAARKTQGVDPMETEASACIDDKERQWKPKKQRRAAFSSERFQPVGLPVLLECLSTQAGTGSLEVVDLQAMHLHSAVTVRCKSAPGDGSCDTDHVRTFHWGCYYCNEVEDDASSVPREEAEAVTLHAGNEIMFRYHKAPQLLTEIEVMGSGLIGLGEEDSFSKTWVPLPLPSDAEPVNCVHNIVGREHFLIQLDNTTVVGFGDNMHGQLGAGKTKDSLILPTVILRTGSVLMCPAGVSGVDLTVRWKVERVNDTLCGVRHSLFVLEVSSFIVNTFANGPWRKWKNVDPATLC
Protein: Galactinol synthase 2 (AtGolS2) (GolS-2) (EC 2.4.1.123) (Q9FXB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Galactinol synthase involved in the biosynthesis of raffinose family oligosaccharides (RFOs) that function as osmoprotectants. Promotes stress tolerance of factors such as drought, chilling, salinity and methylviologen (MV), a superoxide radical generating drug, by mediating an increase in levels of the endogenous osmoprotective compounds, galactinol and raffinose.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Probable galactinol--sucrose galactosyltransferase 5
- Probable galactinol--sucrose galactosyltransferase 2
- Probable galactinol--sucrose galactosyltransferase 1
- Probable galactinol--sucrose galactosyltransferase 6
- UDP-sugar pyrophosphorylase
- ADP-glucose phosphorylase
- UDP-glucose 4-epimerase 2
- UDP-glucose 4-epimerase 5
- Probable galactinol--sucrose galactosyltransferase 4
- Probable peroxygenase 3
Sequence:
MAPEINTKLTVPVHSATGGEKRAYVTFLAGTGDYVKGVVGLAKGLRKAKSKYPLVVAVLPDVPEDHRKQLVDQGCVVKEIEPVYPPENQTEFAMAYYVINYSKLRIWEFVEYNKMIYLDGDIQVFDNIDHLFDLPNGQFYAVMDCFCEKTWSHSPQYKIGYCQQCPDKVTWPEAKLGPKPPLYFNAGMFVYEPNLSTYHNLLETVKIVPPTLFAEQDFLNMYFKDIYKPIPPVYNLVLAMLWRHPENIELDQVKVVHYCAAGAKPWRFTGEEENMDREDIKMLVKKWWDIYNDESLDYKNVVIGDSHKKQQTLQQFIEALSEAGALQYVKAPSAA
Protein: Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) (O60218)
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose.
Subcellular location: Lysosome {ECO:0000269|PubMed:21585341}. Secreted {ECO:0000269|PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
Interaction partners:
- Carbonyl reductase 1])
- Sorbitol dehydrogenase
- Aldehyde dehydrogenase family 3 member A2
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- Aldehyde dehydrogenase X, mitochondrial
- L-xylulose reductase
- Alpha-aminoadipic semialdehyde dehydrogenase
- 4-trimethylaminobutyraldehyde dehydrogenase
- Aldehyde dehydrogenase, mitochondrial
- Aldo-keto reductase family 1 member C3
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
Protein: Protein bicaudal D homolog 1 (Bic-D 1) (Q96G01)
Organism: Homo sapiens (Human)
Function: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Subcellular location: Golgi apparatus.
Interaction partners:
- Ras-related protein Rab-6A
- Dynactin subunit 2
- ATP-dependent DNA helicase DDX11
- Protein bicaudal D homolog 2
- CUGBP Elav-like family member 4
- Cytoplasmic dynein 1 heavy chain 1
- Dynein light chain 1, cytoplasmic
- Dynactin subunit 1
- Cytoplasmic dynein 1 light intermediate chain 1
- Cytoplasmic dynein 1 light intermediate chain 2
Sequence:
MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESFLLKGPPSMSEFIQGHRLSKEKRLTVAPPDCQQPAASVPPQCSQLAGRQDCPTVSPDTALPEEQPHSSSQCAPLHCLSKPPHP
Protein: Dual specificity protein tyrosine phosphatase CCP1 (EC 3.1.3.48) (Q5APU2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Protein tyrosine phosphatase that acts as a repressor of the yeast-hyphal switch. Plays an important role in virulence. Negatively regulates CST20-HST7-CEK1-CPH1 filamentous growth pathway. Represses hyphal genes such as SAP4, SA5, SAP6, and HYR1, by acting through a CEK1-independent mechanism.
Interaction partners:
- Extracellular signal-regulated kinase 1
- Mitogen-activated protein kinase MKC1
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase HOG1
Sequence:
MTTPLSSYSTTVTNHHPTFSFESLNSISSNNSTRNNQSNSVNSLLYFNSSGSSMVSSSSDAAPTSISTTTTSTTSMTGASANADNQQVYTITEEDSINDINRKEQNSFSIQPNQTPTMLPTSSYTLQRPPGLHEYTSSISSISSTSSNSTSAPVSPALINYSPKHSRKPNSLNLNRNMKNLSLNLHDSTNGYTSPLPKSTNSNQPRSNFIMDSPSKKSTPVNRIGNNNGNDYINATLLQTPSITQTPTMPPPLSLAQGPPSSVGSESVYKFPPISNACLNYSAGDSDSEVESMSMKQAAKNTIIPPMAPPFALQSKSSPLSTPPRLHSPLGVDRGLPISMSPIQSSLNQKFNNITLQTPLNSSFSINNDEATNFNNKNNKNNNNNSTATTTITNTILSTPQNVRYNSKKFHPPEELQESTSINAYPNGPKNVLNNLIYLYSDPAQGKIDINKFDLVINVAKECDNMSLQYMNQVPNQREYVYIPWSHNSNISKDLFQITNKIDQFFTNGRKILIHCQCGVSRSACVVVAFYMKKFQLGVNEAYELLKNGDQKYIDACDRICPNMNLIFELMEFGDKLNNNEISTQQLLMNSPPTINL
Protein: Conserved protein (O06597)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Quinolinate synthase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- L-aspartate oxidase
Sequence:
MAHGSTAHEVLAVVFQVRGVGMSRGAAKPQLNVLLWQRAKEPQRGAWSLPGGRLRNDEDMTSSVRRQLAEKVDLRELAHLEQLAVFSDPHRLPGIRMIASTYLGVVPSPATPELPADTRWHPVSSLPPMAFDHGPMVTHARTRLIAKMSYTNIGFALAPKEFALSTLRDIYGAALGYQVDATNLQRVLARRRVITQTGTIAQSGRSGGRPAALYRFTDSQLRVTDEFAALRPPGQL
Protein: Uricase (EC 1.7.3.3) (Nodulin-35 homolog) (Urate oxidase) (O04420)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Subcellular location: Peroxisome {ECO:0000305}.
Interaction partners:
- Uric acid degradation bifunctional protein TTL
- Xanthine dehydrogenase 1
- Allantoinase
- Xanthine dehydrogenase 2
- Inosine-5'-monophosphate dehydrogenase 1
- (S)-ureidoglycine aminohydrolase (AtUGLYAH)
- Dihydropyrimidinase
- Ureidoglycolate hydrolase
- Peroxisome biogenesis protein 5
- Allantoate deiminase
Sequence:
MAQEADGIRLDQRHGKARVRVGRVWRHAHDGSHHFVEWNVSISLLSHCLSSYRLDDNSDIVATDTIKNTVYVKAKECGDRLSVEEFAILIGKHFCSFYPQVFTAIVNIIEKPWERVSIDGKPHLHGFKLGSENHTTEARVEKSGALNLTSGIGGLALLKTTQSGFERFVRDKYTILPETRERMLATEVNASWRYSYESVASIPTKGLYFSEKFMDVKKVLMDTFFGPPETGVYSPSVQRTLYLMGSAVLKRFADVSSIHLKMPNIHFLPVNLSTKENPSMVKFKDDVYLPTDEPHGSIEATLSRITSKL
Protein: AT08303p (KSR) (Kinase suppressor of ras) (Kinase suppressor of ras, isoform B (EC 2.7.11.1)) (Kinase suppressor of ras, isoform C) (Kinase suppressor of ras, isoform D) (Q24171)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase dSOR1
- 14-3-3 protein zeta
- Raf homolog serine/threonine-protein kinase Raf
- Connector enhancer of KSR protein CNK
- Ras-like protein 1
- Protein aveugle
- Serine/threonine-protein phosphatase PP2A
- 14-3-3 protein epsilon
- Hsp90 co-chaperone Cdc37
- MAP/microtubule affinity-regulating kinase 3
Sequence:
MSSNNNAPASAPDTGSTNANDPISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRLNERIPANGLVPHTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLTPSPPNSPFTPSSGLSSSLNGTPQRSRGTPPPARKHQTLLSQSHVQVDGEQLARNRLPTDPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNLSRSAESVF
Protein: Proteasome subunit beta (Q9GRG9)
Organism: Trypanosoma brucei
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
Sequence:
MLADFESVLRSEFSLKDCPRIGPFTWHNIPGVNDAAEDGSALGLNNPLGVSADRTDDFSVMPYSGEELTRDPLCTSNCINSDRRIWKLMLPCPVPRSVPKLDMKKGTTTLGFHFDGGIIIAVDSRASSGQYISSQTVMKVLEINEYLLGTMAGGAADCQYWERVLGMECRLWELRNNCRISVAAASKILANITYQYRNHGLSMGTMVAGWDQFGPSLYYVDDKGTRVKHEIFSVGSGSIYAYGVLDQGYRKNLTVEEACDLARRSIFHATYRDGASGGIVTVYHVHPKGWTQISRDDQTKLYDRYSSQSA