wanglab/gogpt-training-data huggingface dataset:
Protein: Glypican-1 (H7C410)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004471}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004471}; Extracellular side {ECO:0000256|ARBA:ARBA00004471}. Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
Sequence:
MEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR
Protein: Dihydroxy-acid dehydratase ilvC, mitochondrial (DHAD ilvC) (EC 4.2.1.9) (Q4X099)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Dihydroxyacid dehydratase that catalyzes the third step in the common pathway leading to biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively (By similarity). IlvC and the branched-chain amino acid biosynthesis are crucial for virulence and may be a potential target to develop antifungal agents.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P39522}.
Interaction partners:
- Ketol-acid reductoisomerase, mitochondrial
- Branched-chain-amino-acid aminotransferase
- 2-isopropylmalate synthase
- Branched-chain amino acid aminotransferase
- Branched-chain-amino-acid aminotransferase
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Acetolactate synthase
- Histidine biosynthesis trifunctional protein
- 3-isopropylmalate dehydratase
Sequence:
MLLSQTRGRLPSTLRSFSRRALSTTLPRGKDSEETALNKVSRNVTQPISQGASQAMLYATGLTEEDMNKAQVGISSVWYNGNPCNMHLLDLSNRVREGVQKAGLVGFQFNTVGVSDAISMGTKGMRYSLQSRDLIADSIETVMGGQWYDANISIPGCDKNMPGVLMAMGRVNRPSLMVYGGTIKPGCARTQNNADIDIVSAFQAYGQFLTGEITENQRFDIIRNACPGGGACGGMYTANTMATAIEVMGMTLPGSSSNPAESKAKDLECLAAGEAIKRLLKEDIRPSDILTRQAFENAMIVVNITGGSTNAVLHLIAIADSVGIKLDIEDFQKVSDRTPFLADLKPSGKYVMADLHNIGGTPSLLKFLLKEGVIDGSGMTVTGETLAKNLEKVPDFPADQKIIRPLSNPIKKTGHIQILRGSLAPGGSVGKITGKEGTRFVGKARVFDDEDDFIAALERNEIKKEEKTVVVIRYTGPKGGPGMPEMLKPSSALMGAGLGSSCALITDGRFSGGSHGFLIGHIVPEAAVGGPIGLVKDGDTITIDAEKRLLDLDVDETELARRRKEWEALRDAGKLPQTGLTMRGTLGKYARTVKDASHGCITDSVE
Protein: Dual oxidase (EC 1.11.1.-) (EC 1.6.3.1) (Q9VQH2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in innate immunity limiting microbial proliferation in the gut. Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection. May generate antimicrobial oxidative burst through its peroxidase-like domain.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- LD27791p
- Protein immune deficiency
Sequence:
MSVPSAPHQRAESKNRVPRPGQKNRKLPKLRLHWPGATYGGALLLLLISYGLELGSVHCYEKMYSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGANRPSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYDRECRGDKYIPFHRAAYDRDTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPVPSVMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTSLPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFKETPMGYPAVRLCSTWWDSSGFFADTSVEEVLMGLASQISEREDPVLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESYGQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGFVPILCAGAGYCVVKLQNSKRRRLKIRQEALRAPQHKGSVDKMLAREWLHANHKRLVTVKFGPEAAIYTVDRKGEKLRTFSLKHIDVVSVEESATNHIKKKPYILLRVPSDHDLVLELESYGARRKFVKKLEDFLLLHKKEMTLMEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVARMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFENFG
Protein: Glycogen-binding subunit 76A (CBM21 domain-containing protein CG9619) (Q9VVY3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serine/threonine-protein phosphatase alpha-3 isoform
- Serine/threonine-protein phosphatase alpha-1 isoform
- Serine/threonine-protein phosphatase alpha-2 isoform
- Protein phosphatase 1 regulatory subunit
- Glycogen [starch] synthase
Sequence:
MNDPGDIPLTHTSTPDSRPPCSIISIIPTIGMSSCRGRAEAFARSLSSKLRTLGSQTTEEGEGNAEDEPIINGTSTNTWVNSHDSEQTVTDLQPLRHESDSFFDFDCELESPGSPVDECEYLRLIETASNTPHNSTAESGYACASMASSHSSSNDGPYFDASASTSTAAAAQDQTLPASEHKEYVNTLQLNGKHGLANGVQEEQPAFQDDVQEDEAFLQAQILNELQKHSNSLTEVEQTKPEEGKLTNGHLEKVEELELKDVLEVAGTTNRAPKVIAAPQEVEAFADRSQEQSPNDRVQKESSQERVPEGTPFEGVQGESPSDRVQTDASDERVQEEISNDTVQVESNHKSATESISTEVTTLERSPEESRNDELSPDSGVDETDKSASNLTVDVDLAQIEQAKQDATEAVEKSGAPSRGTTVDTTDDEDDCRPQRIRRCSSLKTGKTPPGTPGRKKIVRFADVLGLDLADVKTFLDEIPTIPKSAFEDLEILESEPPLQLGPKSDKLLMPLFQQPGGLPKFLDAVREKQVSLENAAVTDNINQTISGSVRVRNLDFHKSVHIRYSLDGWRSYADLQANYVENSCDGFSDIFTFVLFGNSLHVGQRLEFAVRFQCKGQQFWDNNYGANYCFQCLPSSTHTAGGSTASPPSVATGAVSTGHSASLVGLLSPTAGDAWCSSFY
Protein: Homeoprotein Sail (Mirror) (O01667)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MTVHSNETGICLVMNAVSTHLATSSPNTPPTNAPQSPPSTLPTLACPAAQPLSAPGIAGPGHSGMVTSTVPPGARSTSPCGPSAGLPALSLVGAPPPGPHSSAPGGAPAPGAGNPPNRCCDTGRTIYTDPVSGQTICSCQYDMLNYQRLAAAGGVPLGVYPEGMSAYLSGIAADQPPFYANPAGIDLKENLVAGASPWPYPSMYHPYDAAFAGYPFNSYGMDLNGARRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNRVDDDDANIDDDDDKNTEDNDLLDAKDSGVGSTDDKDRSGRLGDMMTDRPGESNNSEWSESRPGSPNGSPDLYDRPGSMPPGAHPLFHPAALHHHFRPPAGSPPDIAAYHHHQQQLLQQHQQAQQNSLQTAVGGTAKPRIWSLADMASKDSKDSSSGAKDNHPELPPAHPGFYGHPGQQPSPGKILSPLAARIPNYSPYVRPDLYRGFYGPAAAHLGAPTQEFLEHQRTFGASLAAHNGPLGMNPLLWKAAVSGAANGPHFAPLSLTTSGGSSGGQQVAPPPVASPSASSSSSSMGCDVVHIPTSSGQSAAQHMMGPISSNSTASSSSSHSGKISPGVNVTSLSAKP
Protein: ABC multidrug transporter MDR3 (Multidrug resistance protein 3) (F2SG60)
Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)
Function: Pleiotropic ABC efflux transporter involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole.
Subcellular location: Cell membrane {ECO:0000305|PubMed:31501141}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ABC multidrug transporter MDR1
- ABC multidrug transporter
Sequence:
MAPTEEANVTKPTGELRPDEKLNYEEDVKCSGSSSTTVGKTAYDTDDISQSQAAELQDLARQLSRASRQGGLDVENEPQQVINPFLDSESDPELNPDSKSFNVAKWLKTILQITSRDPERFPKRTAGVSFRNMNVHGYGTAADYQSDVGNLPLKAWSGIMSMLGLRKKVRIDILRDFEGLVKSGEMLVVLGRPGSGCSTLLRTLSGETHGLYLDEGNDIQYQGISWEQMHKNFRGEVIYQAETETHFPQMTVGDTLYFAARARAPANRLPGVSREQYAIHMRSMVMSMLSLSHTINTQVGNEYIRGVSGGERKRISIAETTLSGSPLQCWDNSTRGLDSANALEFVKSLRLSTKYSGTTAIVAIYQAGQAIYDIFDKAVVLYEGHQIYFGNAVRAKEYFIEMGFDCPSRQTTADFLTSVTSPSERRVRPGYESRVPQTPAEFAQRWKESEDRRILMQEIDEYNKTYPLHGEQLQKFQASRLAEKSRSTSKSSPYTLSYPMEIKLCMWRGFQRLKGDMSMTLTSIIGNIAMSLIIASVFYNQQETTDSFFSRGSLLFFAILMNAFASSLEILTLWHQRPIVEKHDKYALYHPSSEAISSILVDMPAKLAVAIVFNLIIYFMTNLRRTPGHFFIFFLFSFTTTLTMSNVFRSIAAVSRTLSQALVPTSIFMLALVIYTGFTIPVRDMRPWFKWISYINPIQYAFESLMINEFHDREFKCAVYIPSGPGYSNVSGTSKICAAKGAMAGKPTVSGDVFLRETYSYYASHMWRNYGIIVAFFLFFLFVYITATELVSAKPSKGEILVFPKGKVPAFLKQSKKKQDPEAASTQEKQPVETSGHDQTAAIVKQTSVFHWESVCYDIKIKKESRRILDNVDGWVKPGTLTALMGVSGAGKTTLLDVLANRVTMGVVTGEMLVDGRLRDDSFQRKTGYVQQQDLHLEISTVREALTFSALLRQPNTTPYEEKVAYVEEVIKMLGMEEYANAVVGVLGEGLNVEQRKRLTIGVEIAAKPDLLLFFDEPTSGLDSQTAWSICTLMRKLADHGQAVLCTIHQPSAMLMQEFDRLLFLASGGRTVYFGELGKHMSTLIEYFESKGAPKCPPDANPAEWMLEVIGAAPGSKTDIDWPAVWRDSAERVEVRRHLAELKSELSQKPQTPRLTGYGEFAMPLWKQYLIVQHRMFQQYWRSPDYIYSKACLAIVPTLFIGFTFYKEQVSLQGIQNQMFAIFMFMILFPNLVQQMMPYFVIQRSLYEVRERPSKTYSWIAFMISSVVVEIPWNALLTVPAFFCWYYPIGFYKNAIPTDAVTERSGTMFLLILIFLMFSSTFSSMVIAGIEQAETGGNIAQLCFSLTLVFCGVLVSPTAMPGFWIFMYRLSPFTYFVSAVLSTGVGRTDIVCAANEILRLTPAAGQTCMEYLGPYTKFAGGRILTPDATDMCEFCAVADTDTFLKGVNIIFDERWRNIGILFGYIAFNMVGAIGLYWLLRVPKRKSGVKQGQQPQKQANETKA
Protein: NADH:ubiquinone reductase (non-electrogenic) (EC 1.6.5.9) (F4JGL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side {ECO:0000256|ARBA:ARBA00004137}. Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MRNFSVFERFSKAFKDHPSLTRILVVSTISGGGLIAYSEANASYGANGGAVVETGTKKKKVVLLGTGWAGTSFLKNLNNSQYEVQIISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIGRKNVDTSYLEAECFKIDPASKKVYCRSKQGLSSNGKKEFSVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRKTVIDSFEKASLPELSDEERKRILHFVVVGGGPTGVEFAAELHDFVTEDLVSLYPRAKGSVRITLLEAADHILTMFDKRITEFAEEKFSRDGIDVKLGSMVTKVNEKDISAKTKGGEVSSIPYGMIVWSTGIGTRPVIKDFMKQIGQGNRRALATDEWLRVEGTDNIYALGDCATINQRKVMEDVSAIFSKADKDKSGTLTLKEFQEAMDDICVRYPQVELYLKSKRMRGIADLLKEAETDDVSKNNIELKIEEFKSALSQVDSQVKFLPATAQVAAQQGAYLAKCFDRMEECEKSPEGPIRMRGEGRHRFRPFRIWKLRGISKTLSQDTTESCALDHKGVGKMELIPYIIRYRHLGQFAPLGGEQTAAQLPGDWVSIGHSSQWLWYSVYASKQVSWRTRVLVVSDWMRRFIFGRDSSSI
Protein: Gentisate 1,2-dioxygenase (GDO) (EC 1.13.11.4) (Naphthalene degradation protein I) (O86041)
Organism: Ralstonia sp
Function: Catalyzes the oxygen-dependent ring fission of gentisate between the carboxyl and proximal hydroxyl groups at positions 1 and 2 of the aromatic ring to form maleylpyruvate. Can also catalyze oxidation of alkyl- and halogenated gentisates. Exhibits higher affinity for 3-substituted gentisates than for gentisate but has higher activity with gentisate.
Interaction partners:
Sequence:
MLDEEERITMSHELGRLEDLPQDYRDELKQLNLVPLWPSLRAVLPPNVPTRQTQPTYWSYQTLKPLLLKAGELTPIEKAERRVLVLANPGHGLEKMQASAAIYLGMQLLLPGEWAPSHRHTPNAVRMIVEGEGAYTTVDGEKCPMSRGDLILTPTGLWHEHGHDGNEPVVWLDVLDLPLVYYMEASYHIDGERQQVDPGRGDCAWTRAGVVPTPVFQRSDKRYPLLRYPWADTRAALLSLAADQPEQECVQVTYVNPETGDDAENILGFYALMLKPGQTLRLPVRSPAVVFHQIEGRSEARIAESTFALREADTCCAPGYTEVTLKNLSADQPSFIFMADESPLHRKLGVFENRG
Protein: Catenin delta-1 (Xp120(ctn)) (p120 catenin) (p120(ctn)) (Q8AXM9)
Organism: Xenopus laevis (African clawed frog)
Function: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Required for gastrulation, axial elongation and development of the craniofacial skeleton and eye.
Subcellular location: Cell junction, adherens junction {ECO:0000250|UniProtKB:O60716}. Cytoplasm {ECO:0000250|UniProtKB:O60716}. Nucleus {ECO:0000250|UniProtKB:O60716}. Cell membrane {ECO:0000250|UniProtKB:O60716}.
Interaction partners:
Sequence:
MDEPESESPASILASVRAQEAQFELLSRALEEERRHVTAQLDRVWVTPQEPPLANGSLTRRQQDGLPFLYTPTRMEAHSVHADERYVIDDSSYKSCTLTDESRCSEIPIQTVVGYSQTLDRPYREAAGSGGAYTTVPRNYHFRGPGVDSTMPLISQSPHPGYSSLSRPNQRYRSVDPFRGPGYGPQPQVRGGGLGGSQSDLLSGRIYGSEDAYGLEDDRRSLGGFIDGPDYATTGRRGANGGDPRRRLRSYEDPLSDHFGSIPTSGSLSSLGPAPLTLAPNSGPWRHPELPEVLAMLSYTLDAVRLNAAAYLQHLSYRNEDVKREVCRLRGIPPLISLLEDPRAPIRLAACGALKNLSYGPARENKMAVKNCDGVPALARLLRRRGEGIEGRELAECVTGTLWNLSSLDSVKMELVDQALYTLTQEILVPHSGWQQDGGMQDRVEGKPRHVEWEPALVNTTGCLRNISSERSEARRKMRECEGLVDSVVHILRSEVSHGLVDSKLLENVVCLLRNISYHVHREIPHAEKYMESPQNASAETQNPSCFGVRRGKGKKASEEAVDTVDFPKQTMPAQGYDLLFQPEIVRLYISLVKSSHTPAVLEASAGAIQNLCAGNWVYGRCIRAAVRQEKGLSSLADHLTHESERVVRAICGALRNLCGDNRNRELIGKHALNSLVARLSSSSAQSSALSEDTNVCVINTIHEVISGNLEAAKRLRESQGIERLVLINKGGGRSEREIRAAGFCLQTIWGYKELRRPLEKDGWKKSDFQVSTAATSSVQGYDDSTLPLIDRNLKNEKKSVNADIPLNDFIADQFTHNGDSSNRLPTRSDELSELDPLKECSVSAGGSLNLGDAEDQRV
Protein: Pyruvate dehydrogenase E1 subunit alpha 1 (Q5JPU0)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVVKDEDCVLL
Protein: Trehalose-phosphate phosphatase B (AtTPPB) (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (Q9C9S4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Interaction partners:
- Trehalase
- Alpha,alpha-trehalose-phosphate synthase 1
- Probable alpha,alpha-trehalose-phosphate synthase 2
- Probable alpha,alpha-trehalose-phosphate synthase 10
- Probable alpha,alpha-trehalose-phosphate synthase 4
- Probable alpha,alpha-trehalose-phosphate synthase 3
- Alpha,alpha-trehalose-phosphate synthase 6
- Probable alpha,alpha-trehalose-phosphate synthase 11
- Alpha,alpha-trehalose-phosphate synthase 5
- Probable alpha,alpha-trehalose-phosphate synthase 8
Sequence:
MTNQNVIVSDRKPILGLKTITVSVSNSPLFSNSFPTYFNFPRRKLLKLLEAADKNNLVVAPKITSMIDSMRDSSPTRLRSSSYDSVSDNDDKTSWIVRFPSALNMFDEIVNAAKGKQIVMFLDYDGTLSPIVEDPDKAFITHEMREVVKDVASNFPTAIVTGRSIEKVRSFVQVNEIYYAGSHGMDIEGPTNENSNGQSNERVLFQPAREFLPMIEKVVNILEEKTKWIPGAMVENNKFCLSVHFRRVDEKRWPALAEVVKSVLIDYPKLKLTQGRKVLEIRPTIKWDKGQALNFLLKSLGYENSDDVVPVYIGDDRTDEDAFKVLRERGQGFGILVSKVPKDTNASYSLQDPSQVNKFLERLVEWKRKTVGEE
Protein: Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) (Q09599)
Organism: Caenorhabditis elegans
Function: Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis.
Interaction partners:
- MIF4G domain-containing protein
- Nuclear cap-binding protein subunit 1
- Nuclear cap-binding protein subunit 2
- Sm domain-containing protein
- 3'-5' exonuclease crn-4
- Sm domain-containing protein
- 3'-5' exonuclease eri-1
- Chromatin target of PRMT1 protein C-terminal domain-containing protein
- DNA replication licensing factor MCM7
- Nuclear RNA export factor 1
Sequence:
MAQKTPTKGTRSSPRKKAWGSPIKATAKFQSDIFSVEDFADLSNRSWAEVTEEDDELASRLEEERRCKSESRRKGQPKRAQNSQNKPKFVRSLELTNEVFQSTSSRRSQRSKSRTRNGDTITTVEEHTETVVMESSSGPISRKRCLSNASTINEGASPSKRRPETGKSNRKAPRGRLFTNGGSDSSSVASSPSRRDHWEEPTLGWCTDEAVLKRRSREIDRAKEKAVYQRYTSEVPLRDRIKGQHPRTPNKLINFSRRSWDTQIKKWKRSLYEYCGEEPSDSVNTSFCYSDSDALSEAGDNDKEIENRSVLRDLVIPVTMRPEVDSMASLLGKFDVDSQMGMDESTLKASTNTDPSAPTDFSKMSSH
Protein: Sll1515 protein (P72975)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Ssl1911 protein
Sequence:
MQLSYRGVKYDYNPPKVETEVLGLAGSYRGLDYRFRRTTTKNVIQPNVNLTYRGVSFNPAQDLQPELYTANKKVEVAAAPSQISFQDRVRARLHSKTQAIKKRQQSLLVRLAEEIGLSGDQAVNSAVRIQGKVLANFRSDYASQGVAMS
Protein: Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) (zPHF8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) (P0CH95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes.
Subcellular location: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis (By similarity). {ECO:0000250}.
Interaction partners:
- Lysine-specific demethylase 5D
- Zinc finger protein 711
- Histone H3.2
- Histone H3
- Histone H3.3
- Lysine-specific histone demethylase
- Histone-lysine N-methyltransferase SUV39H1-A
Sequence:
MASVPVYCLCRLPYDVTRFMIECDVCQDWFHGSCVGVEEDKAAEIDLYHCPNCQVTHGPSVMRKRRGAVKHADVGLGRDSGRPVKTGSAQFVRELRCRTFPSADEVLLKPTGAQLTVEFLEERSFSVPVLVLRKDGLGMNLPPSSFSVTDVEHYIGTEKEIDVIDVSRQADLKMKLGEFVEYYNSPNRDRVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEESIFERPNVQKYCLMGVKDSYTDFHIDFGGTSVWYHVLRGEKIFYLIRPTAANLSLFERWSSSSNQNELFFGDQVDMCYKCSVKQGNTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIDMQLRAYEIEKRLSTADLFKFPNFETVCWYVGKHLLDTFRGLRENRRHPATYLVHGAKALNNAFRGWTRKESLGEHEQEIPDTIKTQQLVKDLAKEIRLVEDIFQQNIGRSGTPFGGSQGLPSPHPKAQLNTPLTFSQHLSKKRGPKPKEAFGGGGVGPPGAKKKSQKGKEIKTEAGELDLLEIHTKHTLKKFQPGCKVKKSKLELPDDCLDDFEEKINKSKLKLVLTNGKLQGKKGRAGSANGAGSSLQQFQPHMATLSDFDSEDELQIDETPPPRRRPSLPSKKKLAGLPRKLPRAKPCSDPHRIREPGEVDFDIEEDYTTDEEMLTMQGVKGGAGGILDLLKASKQVAGLDSALSEEAPASPSTRDAIQGMLSMANPPSSSSSSSSSSPLSISGGGEMMGLMKEKGGREGWMSGVKKSERKAVFQRPGKRPIKRPARHLSDDESLDEQETLGTCFKDSDYVYPSLESDEEDHVSKSKMKRKRNWDDTPWSPKARVTPTLPKQERPVREGARVASVETGLAAAAAKLAQQEQQKTITKRKYTKKKTPQEKVHSTVAQLQHQPDSAPVSPPLPSEPPVDCIVEERRVEVYSASLLDHEYTAGPGPFSPGGPRGSGAMAPGVFLTSRRPSLSPQNSSSYSPSAPSPGGLVTPTSAGACQGKRPKKGLATAKQRLGKILKIHRNGKLLL
Protein: Candida glabrata strain CBS138 chromosome L complete sequence (Q6FK95)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome F complete sequence
Sequence:
MRGFKFLKYLEVPVEERQTLSFLKNPDLVPIPKSHQTWGFWSNFAYWGTIAFTVGTWMGATAALTVGLSYPETIATFILGNALTIVYSLANCYPGWDWKVGYTLSQRFTFGIYGSAFGVIIRVLLSIVNYGSNAWLGGLCINLILNSWSHHYLELKNTLSPHVAMTTKELIGFVIFHIVCALCYLMKPYQINRILIIACAGTCFSMLGIIIYLCHANGGAGSLFHTQKTTVSGSDRAWAWVYMISYWFGAVSPGAVNQSDYSRFGSSLKGIYLGTIVGLMIPPNLVPAYGVIGASTTQELYGESMWMPTEICNYWLNHGYHPAARAASFFCGVFFALSQIAYTISNAGFASGMDLAGLLPKYVNIKRGAFFTAIVSVAVQPWNFYNSSSTFLTVMSSFGVVMVPILAVMICDNFIIRKRNYSASQAFILKGEYYFTKGFNWRAFIAMIVPMAPGLPGIAWQVNHNAFNNRGIVNFYYGDSFFAFVMSFCLYWILCIIFPFKINVLQDDKDYYGAFDEKTAIKKGMVPYSELTEVERQEYFIPTANVVMKEEQPTESDSEISRAYVEEGTEKGSTKDGVAEI
Protein: Chlorophyllase-2 (AtCLH2) (EC 3.1.1.14) (Chlorophyll-chlorophyllido hydrolase 2) (Chlase 2) (Q9M7I7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of ester bond in chlorophyll to yield chlorophyllide and phytol. Does not seem to be required for chlorophyll degradation during senescence.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17996203, ECO:0000269|PubMed:31779896}. Note=Associates with the tonoplast and endoplasmic reticulum. {ECO:0000269|PubMed:31779896}.
Interaction partners:
- Chlorophyll
- Protochlorophyllide reductase A, chloroplastic
- Probable chlorophyll
- Chlorophyllide a oxygenase, chloroplastic
- Protochlorophyllide reductase B, chloroplastic
- Protochlorophyllide reductase C, chloroplastic
- Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic
- 7-hydroxymethyl chlorophyll a reductase, chloroplastic
- Chlorophyll synthase, chloroplastic
- Magnesium dechelatase SGRL, chloroplastic
Sequence:
MSSSSSRNAFEDGKYKSNLLTLDSSSRCCKITPSSRASPSPPKQLLVATPVEEGDYPVVMLLHGYLLYNSFYSQLMLHVSSHGFILIAPQLYSIAGPDTMDEIKSTAEIMDWLSVGLNHFLPAQVTPNLSKFALSGHSRGGKTAFAVALKKFGYSSNLKISTLIGIDPVDGTGKGKQTPPPVLAYLPNSFDLDKTPILVIGSGLGETARNPLFPPCAPPGVNHREFFRECQGPAWHFVAKDYGHLDMLDDDTKGIRGKSSYCLCKNGEERRPMRRFVGGLVVSFLKAYLEGDDRELVKIKDGCHEDVPVEIQEFEVIM
Protein: Combover, isoform C (M9PFI2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAPPPKVVVDQANASARSNGSSNNNSVGGATGAVPKQQTPVNGAPTSGSSASVTSSRSARSRRQQEHLGEPDMELVEPETLQRETLKTLNDLLQRARITNAKNRSPAEQHLSSKDHRSPAQQQQQREALRQLAAEHGNYDTAEQLQEQQQRYRFPVRPVQRVQHQPSSSANSTGAPSSSTALLRLRQSTPPNATVGVVIPNATTSNGNGNLSGNEEQAPPLTPAGLQQLVHRLLGVHHFAPRTEGFRSQVDVLRALLGLDENLNSRYQPSRKVVETNNMVHEINPNSDQGEGVVNSTSLEDVALSEMSDNRAQSIQSLHSVLETPTPDTTPSFDELQQRLEASNRNMQHLHDEQAKLLQIQNLAKTHLNEMERLRQQADSLPHNVNGGEAPKYESVQQVQDDMASLVGRMKNLTAFIHNQNELSTVLGDDGPEILAEQEALQEKLESLRTQREDMRNLVDELNSINRAARETARVIKEKEETPTPPPKPEEAAPAAPKERVVPVEYQRNVPIIRQEAANAAQRALHAQAMINQKTADIEALKAQMARLKGMLYTVSQIEESTPSMGSTLERRSEERTSVERELPAEIAQRVFALNDVTSELRAEAASLQKERDRILALKAEIERRKQQAAAAVQMGDDALKRSSLTPTPTPMRQRMTEEEDPSEVDNSLQATPTKEQLRDELRSQCERLRTEYEQKQRELEQRYVASNNTTSEADDEANDDTDSDKYFANQAPPPPPPAPPSTLNEDDLNVTLDTLSLGNDSIPSSSNRSQYMPPPMQPVPGMWAASHNSGSSWHGQQPVYGQPSSSAGTEFKKLPAAQQGGSSNGSGSNASTDAVLLQQFMQTQQMLINSVCQCNQALWHQQREIDNLNHQLHALQDRFNVVACQDHSFGLRSESVPPPVGPGMGQMPNNLCLGSSRAQSEQLFNFGAHQSAFSNYQRSCHRSGAESHHHQQQQHQAQPFLNNAAPPPPPTHFNNETPLSPPTYRSSPGPIFMNHHNNTIHQNNSNLRTQNQHANNLHSLPEGAAGGGAPGGGITLNNQVPPGNRANNYWDNFRSHSRQNLLSNKSNEELNVDLQQYRRQRARPSYFQPPQLLPPTTRGGLTHQQQRRHFFEAPLTALHGSSSNGSNNLNNSGSSGRKRDWRDDAGHIRDHDDEDVDEVEENHDNVIFGSGRRRNRRRPQLSTLRDDESEQASSSNLNMNVNYGNSPLYQRNKVPAKPTTSTVSLTPLQQRHLRFDFELPAHYMDYIELPQITPVDTTPTLGQEASPADESNAMEQTEETASEELNRNLLVNALKNDKFTTKFYESIKEDVYRRLETLFEQQQQQQQQQQQQNQQLQHSHEPHGLRKALNQEENEPTGDAEATESRSETPLEVMRLQLDNDRPEDEKGTPVKQLSLSNPQNGQHLDEMEDSASAVISSLRTENEEQILEGKLEQASGSGSGPGTSIELAPDHELIEYIIKRIRNQTHNNTVINDSLLAEVSKLTATAAQNSTASSPLISPKRIYAKIKKMDIPRQRDEFLLWYRSYLEQLFVVEQPQDSCKTKSKVTPSGASPAKLKNQRVRKQSQSQSQDSNNDADLAEADQKNVSSAGNGELECENNENPDEEADGQAAAEPSGAEKQDVSLE
Protein: Mce-family protein Mce2B (O07788)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Mce-family protein Mce2A
- Conserved hypothetical integral membrane protein YrbE2B
- Mce-family protein Mce2C
- Mce-family protein Mce2D
- Conserved hypothetical integral membrane protein YrbE2A
- Possible Mce-family lipoprotein LprL
- Mce-family related protein
- Mce-family protein Mce2F
- Conserved integral membrane protein YrbE4B. Possible ABC transporter
- Conserved integral membrane protein YrbE4A. Possible ABC transporter
Sequence:
MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYLNLIGDRYLELGRGHSGQRLAPGATIPLEHTHPALDLDALLGGFRPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAAGTLADLLGRIVHCCTAASGTSRASSSRS