wanglab/gogpt-training-data huggingface dataset:
Protein: Hemin/hemoglobin-binding protein 2 (Hn/Hb-binding protein 2) (P64) (Surface virulence-associated protein A) (Q7AP54)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Function: Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable). At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable). Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1. May be involved in crossing the digestive barrier in infected animals. Binds host hemin (Probable). Binds host hemoglobin with affinity in the nanomolar range.
Subcellular location: Cell surface {ECO:0000269|PubMed:11700342}. Secreted, cell wall {ECO:0000269|PubMed:15028680, ECO:0000269|PubMed:16247833, ECO:0000269|PubMed:19129190, ECO:0000269|PubMed:21725001}; Peptidoglycan-anchor {ECO:0000269|PubMed:16247833, ECO:0000269|PubMed:19129190, ECO:0000305|PubMed:15028680}. Secreted {ECO:0000269|PubMed:15028680, ECO:0000269|PubMed:15661014, ECO:0000305|PubMed:11700342}. Note=Most protein is secreted (PubMed:15028680, PubMed:15661014). Cell wall attachment is iron-regulated, only occurring when iron levels are low or fur is deleted (PubMed:15661014). Cell wall-anchored protein localizes to one cell pole or laterally (PubMed:15028680). Protein does not have to be cell wall-anchored for virulence (PubMed:15028680). During exponential growth detected on the cell surface as a series of dots in a helical pattern, it is excluded from the septum (PubMed:21725001). The helical pattern of InlA does not overlap with that of InlH, InlJ or Hbp2 (PubMed:21725001). Under iron-limiting conditions accumulates at the old cell pole (PubMed:21725001). {ECO:0000269|PubMed:15028680, ECO:0000269|PubMed:15661014, ECO:0000269|PubMed:21725001}.
Interaction partners:
- Hemin/hemoglobin-binding protein 1
- Sortase B
Sequence:
MKKLWKKGLVAFLALTLIFQLIPGFASAADSRLKDGGEYQVQVNFYKDNTGKTTKESSEADKYIDHTATIKVENGQPYMYLTITNSTWWQTMAVSKNGTRPEKPAQADVYQDRYEDVQTVSTDAAKDTRVEKFKLSSLDDVIFSYMHIKVDAISYDHWYQVDLTIDPSTFKVISEPAVTTPVTLSDGIYTIPFVAKKANDDSNSSMQNYFNNPAWLKVKNGKKMVAMTVNDNKTVTALKTTLAGTLQDVKVVSEDKDANTRIVEFEVEDLNQPLAAHVNYEAPFNGSVYKGQADFRYVFDTAKATAASSYPGSDETPPVVNPGETNPPVTKPDPGTTNPPVTTPPTTPSKPAVVDPKNLLNNHTYSIDFDVFKDGTTETSMMESYVMKPALIKVENNQPYVYLTLTNSSWIKTFQYKVNGVWKDMEVVSGDINKNTRTVKYPVKDGTANTDVKTHVLIEDMPGFSYDHEYTVQVKLNAATIKDITGKDVTLKEPVKKDILNTGNVASNNNAGPKLAKPDFDDTNSVQKTASKTEKNAKTNDSSSMVWYITLFGASFLYLAYRLKRKRLS
Protein: Putative pentatricopeptide repeat-containing protein At1g17630 (Q9LNP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVHASLWQFRLQIIPWRLRNFCFLTSQCPYTSISSPDTVSVSSYYSLTSNNDQSLFHYFDHLLGLCLTAQQCRQVHAQVLLSDFIFRSGSLAANLISVYARLGLLLDARNVFETVSLVLLSDLRLWNSILKANVSHGLYENALELYRGMRQRGLTGDGYILPLILRACRYLGRFGLCRAFHTQVIQIGLKENLHVVNELLTLYPKAGRMGDAYNLFVEMPVRNRMSWNVMIKGFSQEYDCESAVKIFEWMQREEFKPDEVTWTSVLSCHSQCGKFEDVLKYFHLMRMSGNAVSGEALAVFFSVCAELEALSIAEKVHGYVIKGGFEEYLPSRNALIHVYGKQGKVKDAEHLFRQIRNKGIESWNSLITSFVDAGKLDEALSLFSELEEMNHVCNVKANVVTWTSVIKGCNVQGRGDDSLEYFRQMQFSKVLANSVTICCILSICAELPALNLGREIHGHVIRTSMSENILVQNALVNMYAKCGLLSEGSLVFEAIRDKDLISWNSIIKGYGMHGFAEKALSMFDRMISSGFHPDGIALVAVLSACSHAGLVEKGREIFYSMSKRFGLEPQQEHYACIVDLLGRVGFLKEASEIVKNMPMEPKVCVLGALLNSCRMHKNVDIAEGIASQLSVLEPERTGSYMLLSNIYSAGGRWEESANVRALAKKKDLKKVSGSSWIEVKKKKYKFSSGSIVQSEFETIYPVLEDLVSHMLKKGPTHDGNNYEDDLDLWTA
Protein: Putative WEB family protein At1g65010, chloroplastic (F4I8B9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
Sequence:
MASRTKTGLMETPRSKPSPPPPRLSKLSASKSDSNSASPVPNTRLSLDRSPPTVNSKPTPDRRPSRIPTPEKVHSRLVKGTELQTQLNQIQEDLKKADEQIELLKKDKAKAIDDLKESEKLVEEANEKLKEALAAQKRAEESFEVEKFRAVELEQAGLEAVQKKDVTSKNELESIRSQHALDISALLSTTEELQRVKHELSMTADAKNKALSHAEEATKIAEIHAEKAEILASELGRLKALLGSKEEKEAIEGNEIVSKLKSEIELLRGELEKVSILESSLKEQEGLVEQLKVDLEAAKMAESCTNSSVEEWKNKVHELEKEVEESNRSKSSASESMESVMKQLAELNHVLHETKSDNAAQKEKIELLEKTIEAQRTDLEEYGRQVCIAKEEASKLENLVESIKSELEISQEEKTRALDNEKAATSNIQNLLDQRTELSIELERCKVEEEKSKKDMESLTLALQEASTESSEAKATLLVCQEELKNCESQVDSLKLASKETNEKYEKMLEDARNEIDSLKSTVDSIQNEFENSKAGWEQKELHLMGCVKKSEEENSSSQEEVSRLVNLLKESEEDACARKEEEASLKNNLKVAEGEVKYLQETLGEAKAESMKLKESLLDKEEDLKNVTAEISSLREWEGSVLEKIEELSKVKESLVDKETKLQSITQEAEELKGREAAHMKQIEELSTANASLVDEATKLQSIVQESEDLKEKEAGYLKKIEELSVANESLADNVTDLQSIVQESKDLKEREVAYLKKIEELSVANESLVDKETKLQHIDQEAEELRGREASHLKKIEELSKENENLVDNVANMQNIAEESKDLREREVAYLKKIDELSTANGTLADNVTNLQNISEENKELRERETTLLKKAEELSELNESLVDKASKLQTVVQENEELRERETAYLKKIEELSKLHEILSDQETKLQISNHEKEELKERETAYLKKIEELSKVQEDLLNKENELHGMVVEIEDLRSKDSLAQKKIEELSNFNASLLIKENELQAVVCENEELKSKQVSTLKTIDELSDLKQSLIHKEKELQAAIVENEKLKAEAALSLQRIEELTNLKQTLIDKQNELQGVFHENEELKAKEASSLKKIDELLHLEQSWLEKESEFQRVTQENLELKTQDALAAKKIEELSKLKESLLEKETELKCREAAALEKMEEPSKHGNSELNSIGKDYDLVQFSEVNGASNGDEKTKTDHYQQRSREHMIQESPMEAIDKHLMGERAAIHKVAHRVEGERNVEKESEFKMWDSYKIEKSEVSPERETELDSVEEEVDSKAESSENMDQYSNGFSLTDHTEDSGNLLLKEQHMKKKKPLLRKFGNLLKKKSTSSSSQK
Protein: Sterol 3-beta-glucosyltransferase (EC 2.4.1.173) (G4RIN9)
Organism: Starmerella bombicola (Yeast) (Candida bombicola)
Interaction partners:
Sequence:
MQETLSSQQPDAQPQRISNSEEQQYDDSAFNSDADDEDGLEKIQRFFTGESSAYYGQDDEDLNAREREYVTQLLSEEGEAGLSVGRFEGWLGKTVLLQGKIFITNRYFLFYAHLPVTNGTLKASPLAKKSVRHLVGIGKASYIRFWFVLRAGALLWYEDPGDIFFPAGLLSLNLMSEIRVVPEAPEKFCIKSLTGKVYTFKADSRNAANEWVKAIEKEIFKARNNNTAPSVVVRIPLKNMISLKTLKPLDFVDVIEFLAITQGSVNPAESQVGKFTFAFFGDQKTLNSIIDRISTSTNNFEHQKGVKFNTTAEGEELDLAHSQVGPVDESVFDTTRASNTDVFEFKYVSDDREAVRLAGEDETESGSQVSSQLTSEHSSSLNLSPISSHGNRRSFFSKSSLRSSTLLHSRIPTRSGTPSKSPTPTDSYSHSKSKTNLFSTLNEKLHKLKHDDSKIDLAPIIAMPKKLIPNLGEQSHDVSDTEEGADSDDDEESQDDSKINLNLPQVLSQKLSIFSSDPSTDTSMASEAQSSQLDLNSLNQKFRERFGLPSFVNLLAEYQRSFKKPNDSSSWSGTLLVASDYLCFNRQKSGSSCHRMIIPLKDIIHIKKEPMQSSNLEFEVAETAYSEFSLKFPEPADRKDADDMTRSVWQQQRTKDEGNTLRGNSNNHDTIDSEAQFLEYSLRSARLSTYEPTVTSQLKRRIPPLMFDPTSTQYKEIFLQKPMKTLTFAMMMIGSRGDVQPYLALCQGLMEEGHKCIILTHGEFKETVEGYGIEFREIAGDPRELMELMISHGSISYSFIREVLSHFKSWLKELMKTAWKAMKDSGADVFIESPSSMIGIHIAEALNIAYYRAFTMPWTKTKAYPQALLAPDQKRAGNYNAFTYVMYDRLVWFGISKYVNKWRKHMGLPETDLDTLHQEDVPFLYCVSPTVLVPPLDQPDWVHTCGYWELRPNEDKKESGDAKVAAFIKKAREDKVPVGYIGFGSIIVSDPEAMTQTIIDAVDQSGVRCVVARGWSSRSTKKKDNDDESDSTEKKPLNHENICDVDSVDHQWLFPQMDVCVHHGGSGTTGASLRAGKPTIIKPFFGDQFFYGRRVEDLGVGRNLKKLSTKGLAEALKECTTNKQMIRQADVLGEQIRHEHGVEEAILCIYRELAYAKDVTIRRRNATLEASKNGLFSDPLGLLNPAELFSHKDRSEAEILEKEDGGAAKNKDKDHLWFTLPKFGRREEQRQNRDADDEIDVSV
Protein: Protein kinase gsk31 (EC 2.7.11.1) (Q9URT9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Regulator of G-protein signaling 1
- Casein kinase I homolog hhp2
Sequence:
MSDDSHLETKVVTDGTTGEKKTISYEPCRVLGSGSFGVVIQAKLVGTPGFIAVKRVLQDKRYKNRELQIMRAISHPNIIKLIAFFHTHNPSKDETHLCLLLEYMPETVFDDMRWYTRRRKSIPNLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNLLVDYKTGILKLCDFGSAKVLVPSEPNVSYICSRYYRAPELVFGATHYTTKIDVWSAACVIAELFIGRPLFPGDSSVEQLVEIIRVLGTPSYHEISVMNPNYVNHSLPNVRPHTLESVMPHNCTKNAMDLLHKMLTYVPSKRISAIEVLTHPFFDELRDPNCMYHCSRDEGTIERHLPPLFNFNLAELSIRPNLNKAILPPHVYESLDVDINNFEPIVVKQADADS
Protein: Uncharacterized protein (Q386E8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL4m
- AMP-dependent synthetase/ligase domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L22p/L17e
- AB hydrolase-1 domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLKCSLCYLASKVTAGNAKNQAGHPRRRAKLFHVVPGTPVTPFEKLKEQRRRFGQDRHSRLPEYRPGNNVRMDPNTYTLYATKKGVMTIRESRINPKYKWLDVEPDIQKVYRSRELRRALQEREMASMAVGENSNYRVELDLLLEPDWRERVMHVPKATERFKDPNLFTRGVVNELSPLDRYSYT
Protein: Small ribosomal subunit protein eS12 (40S ribosomal protein S12) (Q54PX9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS4
- Small ribosomal subunit protein eS10
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL30
Sequence:
MEGDAPVIAANPLEKNTDPMVALQKVIKESLAVQGVARGLHETVKALDKRTARLCVLASNCDEPNFVRLVKALATEHNIPLIEVPDNKALGEWAGLCKLDKDLAARKVVACSTLVIKTFGKESDDYKFLMEYISKQ
Protein: NAC domain-containing protein 10 (ONAC010) (NAC transcription factor ONAC010) (Q8H4S4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor of the NAC family associated with male fertility. Involved in anther development, but not in senescence. Reduced expression of NAC5 via RNAi leads to male-sterility.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- Os04g0589400 protein
Sequence:
MESPDSSSGSAPPRVLRRQQQQPGSAPELPPGFRFHPTDEELVVHYLKKKAASVPLPVTIIAEVDLYKFDPWDLPEKANFGEQEWYFFSPRDRKYPNGARPNRAATSGYWKATGTDKPIMSSGSTREKVGVKKALVFYRGKPPKGVKTNWIMHEYRLTDTSSSAAAVATTRRPPPPITGGSKGAVSLRLDDWVLCRIYKKTNKAGAGQRSMECEDSVEDAVAAYAPSSQQHATAAAGMAGSDGAGGVAAAHGGDYSSLLHHDSHEDTFLVNGLLTAEDAAGLSTGASSLSQLAAAARAAATPCDATKQLLAPSPTPFNWFEAFLPRAKEFPSGLSRSSRDIGDMSLSSTVDRSLSEAGAVAIDTGDAANGANTMPAFINPLGVQGATYQQHQAIMGASLPSESAAAAAACNFQHPFQLSRVNWDS
Protein: Transcription factor HES-5 (Class B basic helix-loop-helix protein 38) (bHLHb38) (Hairy and enhancer of split 5) (Q5TA89)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 3
- Transcription factor HES-1
- Neurogenic locus notch homolog protein 2
- Delta-like protein 1
- Recombining binding protein suppressor of hairless
- Protein jagged-1
- Signal transducer and activator of transcription 3
- Neurogenic locus notch homolog protein 4
- Mastermind-like protein 1
Sequence:
MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYHFQRPPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAAHQPACGLWRPW
Protein: Zinc finger protein 699 (Hangover homolog) (Q32M78)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEEERKTAELQKNRIQDSVVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLGYPLHTPHLISQWEQEEDLQTVKRELIQGIFMGEHREGFETQLKTNESVASQDICGEKISNEQKIVRFKRNDSWFSSLHENQESCGIDYQNKSHERHLRNHMVENIYECYEENQDGQTFSQVPNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKKHMKTPTEEKPYECKECTKAFSCSSFFRAHMKIHIGKTNYECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKRIHSGDKPYECKECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKECGKAYNCPSSLSIHMRKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSCPSSFRAHVRDHTGKIQYECKECGKTFSRSSSLTEHLRTHSGEKPYECKECGKAFISSSHLTVHIRTHTGEKPYECKKCGKAFIYPSALRIHMRTHTGEKPYECKECGKAFRHSSYLTVHARMHTGEKPFECLECGKAFSCPSSFRRHVRSHTGEKPYECKECGKAFVCPAYFRRHVKTHTRENI
Protein: Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Uridine monophosphokinase 2) (Q99PM9)
Organism: Mus musculus (Mouse)
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor.
Interaction partners:
- Uracil phosphoribosyltransferase homolog
- Uridine 5'-monophosphate synthase
- Uridine phosphorylase 1
- Cytidine deaminase
- UMP-CMP kinase
- Uridine-cytidine kinase 1
- Uridine-cytidine kinase-like 1
- Ectonucleoside triphosphate diphosphohydrolase 3
- UMP-CMP kinase 2, mitochondrial
- Ectonucleoside triphosphate diphosphohydrolase 8
Sequence:
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYHQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGLSKRQTNGYLNGYTPSRKRQASESSSRPH
Protein: Fibroblast growth factor receptor homolog 2 (EC 2.7.10.1) (Protein breathless) (Tyrosine kinase 2) (dTk2) (Tyrosine kinase receptor HD-311) (dFGF-R1) (Q09147)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Fibroblast growth factor
- Stumps, isoform E
- FI03681p
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- E3 ubiquitin-protein ligase CBL
- FI19443p1
- Endophilin-A
- Pyramus
- Fibroblast growth factor receptor homolog 1
- Thisbe
Sequence:
MAKVPITLVMIIAIVSAAADLGCDYGHHRCYIDVTVENSPRQRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETSPLRYQYTYKFN
Protein: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A) (P30745)
Organism: Escherichia coli (strain K12)
Function: Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).
Interaction partners:
- Cyclic pyranopterin monophosphate synthase
- Molybdopterin synthase catalytic subunit
- Molybdenum cofactor biosynthesis protein B
- Molybdopterin synthase sulfur carrier subunit
- Molybdopterin molybdenumtransferase
- Molybdopterin adenylyltransferase
- Molybdenum cofactor guanylyltransferase
- Molybdopterin-synthase adenylyltransferase
- GTP cyclohydrolase 1
- GTP cyclohydrolase-2
Sequence:
MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFARLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVASWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSIGKLHLCLFGEGGVNLRDLLEDDTQQQALEARISAALREKKQTHFLHQNNTGITQNLSYIGG
Protein: Uncharacterized protein (Q582L1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNQSPFDHPRSCHGKEVGSASDTAARSACTRCRGAATHGFAVGETVYAPKRSEGKPLRYALAEVTGIQATARTVTVSFLGTEPGVDDEAVPFYTVVPSPGEVIPTVDNTNGGAYFSPFRRVGKSGAGAGSTLNPPRGKGGKTRVDPAKNSNDNELSGVEVCRRNAEAPERGIPTLCQLAEAFPSDVQQRNGWRVLCVPHHHDESFNAFSARAFGAACLTMNGCLKSAPRTTGGWVVLSVFTTYDSLHHFDVYMTLRGYRVCLADGTVHPTGFRGGPAVSSIQYDERETLWLCILADDIANEGSASALVGEWLPCGVQRQHPNAGKCGDNLIKVGVVQFVEEWKKEKVESEPWMESDDVERAIRKLLAAVGADAHTLIKCHLPDHVGEDELVISSLMSDGSTVIGSKWWKQSRSSSTVRQRTRPTFELCLPATSWQIDLLRALEPRGGLIKQEDTDFPPPSASNAADNEYARGRVSSPTPLQAIANGDVFNTALSRAVACGEGAGLLRDLQRRVVCNAGFLGEEVSPLFCAIHAVLQDVLPQPESGTAVQWKRVVICLPGVSNRASASVAYRHAIQRFLYPWRLHFLATDEWQRTSDSATMESLSWLQMGGVMLLSMEEPLCQLSSLKEEADIVIECGKCSATPRTPRDGVTHIVLFSEVEIPGGPTPLLSSWRPANKAIDRALEQAVVRRTMSHTQPSVGTHIFMKAAALIEELDGKENHQTERRMLSRKRQTVEDEAWVHLRKFAVHLLVCSCHFQETR
Protein: Transcription enhancer factor-like protein egl-44 (Egg-laying defective protein 44) (Q19849)
Organism: Caenorhabditis elegans
Function: Transcription factor. Binds to DNA sequence motif 5'-CATNNNNAAATGCAT-3' as a heterodimer with egl-46. Represses expression of genes involved in differentiation of touch receptor neurons (TRN), probably acting as a heterodimer with egl-46, perhaps by occupying similar cis-regulatory elements as an unc-86/mec-3 heterodimer. Plays a role in cell fate specification of neurons, including the hook neuron HOB, and touch receptor neurons. Involved in male mating behavior, acting in concert with egl-46, via modulation of expression of polycystins lov-1 and pkd-2, homeodomain protein ceh-26, and neuropeptide-like protein nlp-8. Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Plays a role in neuron differentiation by repressing the expression of zag-1 in FLP neurons, probably acting as a heterodimer with egl-46; because zag-1 represses expression of egl-46 and egl-44, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. Plays a role in specifying commissural dendrites of the PVD nociceptive neurons, acting in concert with egl-46. May be involved in thermal stress response downstream of yap-1.
Subcellular location: Nucleus {ECO:0000269|PubMed:11274062}.
Interaction partners:
- Yes-associated protein homolog 1
- Transcription factor egl-46
- dUTP diphosphatase
- Serine/threonine-protein kinase WARTS homolog
- Zinc finger E-box-binding homeobox protein zag-1
- Signal peptidase complex catalytic subunit SEC11
Sequence:
MNSMFCSELQQALPQMSEDVAVTAQTILNGTPPHNHFRKEWLAGAAGTTTPTTTSGGQMMTLSPPAGDGPGSAGSMAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE
Protein: Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] (Q8C3Q9)
Organism: Mus musculus (Mouse)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Interaction partners:
- E3 ubiquitin-protein ligase XIAP
- Apoptotic protease-activating factor 1
- Cytochrome c, somatic
- Cytochrome c, testis-specific
- Caspase-3
- Baculoviral IAP repeat-containing protein 3
- Baculoviral IAP repeat-containing protein 2
- RAC-alpha serine/threonine-protein kinase
- Baculoviral IAP repeat-containing protein 7
- Poly [ADP-ribose] polymerase 1
Sequence:
MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFFKTS
Protein: Acid-sensing ion channel 1B (ASIC1-B) (Acid-sensing ion channel 1.1-B) (Amiloride-sensitive cation channel 2-A, neuronal-B) (ZASIC1.1) (Q708S8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14970195}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q1XA76}. Postsynaptic cell membrane {ECO:0000305|PubMed:14970195}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6NXK8}.
Interaction partners:
Sequence:
MVRITCTISFSTDDEPVGRSRQGSFDDHYKRVVWSKDGEQGKYQEEGDDPDAYDGPEDEEAPDISLATFFGGCSLHGANHVFVEDKKFSIRQGLWALVFLLAISMFLLQVVDRVIYYLQYDYVTLLDERNAKNMTFPAITLCNYNTFRRSQLSYSDLLFMGPLLGYEDNMAPGIPLAPEPDRQGSRFSLAEFFNRTRHRMDDMLLECNFAGKECGAEHWREIFTRYGKCYTFNSGQDGRPLLITTKGGMGNGLEIMLDIQQDEYLPVWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKATPIDSDFFNTYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVERDNDYCVCETPCNMTRYGKELSFVRIPSKASAKYLAKKYNKTEQYISDNIMVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYLYEVIKFKLCRCAKKKHQRSNNNERGAVLSLDDVKRHAPCDNLRTPSTYPANMLPHHPGQGNFEDFTC
Protein: PHF1 (A0A1U9X8A3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTRAGPWGRGLTSPGEAPEAGARAPEEEAEGESGGAGATLSSAQSARAPGAEGAGSSAEGTAAAPSGCLLPSTLLPAPQGPLGTVDPQTGHPWNFTLVSPQTSLKVPPTR
Protein: Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) (P98166)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
Interaction partners:
- Reelin
- Disabled homolog 1
- Apolipoprotein E
- Proprotein convertase subtilisin/kexin type 9
- Clusterin
- Lipoprotein lipase
- Apolipoprotein B-100
- Thrombospondin-1
- SH3 domain-containing kinase-binding protein 1
- Low-density lipoprotein receptor-related protein 8
Sequence:
MGTSARWALWLLLALCWAPRDSGATASGKKAKCDSSQFQCTNGRCITLLWKCDGDEDCTDGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPESWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCRTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDITKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIIYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTPVTYSETKDVNTTDILRTSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA