wanglab/gogpt-training-data huggingface dataset:
Protein: TIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-related adapter molecule) (Toll/interleukin-1 receptor domain-containing protein) (Q8BJQ4)
Organism: Mus musculus (Mouse)
Function: Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:18297073}. Early endosome {ECO:0000269|PubMed:18297073}. Late endosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q86XR7}. Note=Localized to the plasma membrane as a result of myristoylation. {ECO:0000250}.
Interaction partners:
- TNF receptor-associated factor 6
- Toll-like receptor 4
- Toll-like receptor 3
- Mitogen-activated protein kinase kinase kinase 7
- Toll-like receptor 2
- TNF receptor-associated factor 3
- Glycogen synthase kinase-3 beta
- Transmembrane emp24 domain-containing protein 7
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 9
Sequence:
MGVGKSKLDKCPLSWHKKDSVDADQDGHESDSKNSEEACLRGFVEQSSGSEPPTGEQDQPEAKGAGPEEQDEEEFLKFVILHAEDDTDEALRVQDLLQNDFGIRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVSRQHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVFERQQSIWKETRSVSQKQFIA
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q382Y7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- TAP42-like protein
- Serine/threonine-protein phosphatase 2A activator
Sequence:
MSDLNAMIETLYAGRLITERQVVQLCDWCKDIFLEEGNVDVVFAPVTLCGDIHGQFFDLLELFRHGGRVPDTSYVFMGDYVDRGYHSVETLILLLLLKVRYPDRITLLRGNHESRQITQVYGFYDECYRKFGSATVWRLCTDLFDYMPLSAVVEGSVFCVHGGLSPHIATLDEIRALDRKQEVPHDGPMSDLLWSDPDEMEGWGVSPRGAGFIFGGDVAKTFNHKNGLSLIARAHQLVFEGYKSMFDDNCCTVWSAPNYCYRCGNVGSIMRIGEQSLTDRSFITFGAASAETRGHLTKQTPPEYFL
Protein: Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10) (Q921A3)
Organism: Rattus norvegicus (Rat)
Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O15205}. Cytoplasm {ECO:0000250|UniProtKB:P63072}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme 6
- Negative regulator of ubiquitin-like proteins 1
- Ubiquitin-like protein NEDD8
- Proteasome
- Proteasome subunit beta type-8
- Next to BRCA1 gene 1 protein
- Proteasome subunit beta type-9
- E3 ubiquitin-protein ligase TRIP12
- Zinc finger-containing ubiquitin peptidase 1
- Ubiquitin conjugating enzyme E2 V1 like 1
Sequence:
MASCVCVVRSEQWPLMTFDTTMSDKVKKINEHIRSQTKVSVQDQILLLDSKILKPHRALSSYGIDKENTIHLTLKVVKPSDEELPLSLVESGDEGQRHLLRVRRSSSVAQVKEMIENVTAVPPKKQIVNCNGKRLEDGKIMADYNIKSGSLLFLTAHCIGG
Protein: Spermatogenesis-associated protein 19, mitochondrial (Spermatogenic cell-specific gene 1 protein) (Spergen-1) (Q920Q3)
Organism: Rattus norvegicus (Rat)
Function: Essential for sperm motility and male fertility (By similarity). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9DAQ9}. Mitochondrion {ECO:0000269|PubMed:11967211}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAQ9}. Note=Localizes to the midpiece of the sperm flagellum. {ECO:0000250|UniProtKB:Q9DAQ9}.
Interaction partners:
- Testis expressed 35
- Sperm microtubule inner protein 10
Sequence:
MIITTWIMYILARKSIGLPFPPRVNSDIEVEETEAVSVVQHWLNKTEEEASRSIKEKISINDPCTQGHDIHVTRDLVKHRLSKCDMLTDPNQEVLEERTRIQFIRWSHTRIFQVPSEMMDDVIQERIDQVRRSVSHLRCDSSSDPCYRNSCSEC
Protein: Phosphatidylinositol 4-kinase gamma 5 (AtPI4Kgamma5) (PI-4Kgamma5) (PI4K gamma 5) (EC 2.7.1.67) (Q9C671)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Interaction partners:
- LAZY1
- AP-5 complex subunit zeta-1
- Phosphatidylinositol 4-kinase alpha 1
- Anther-specific proline-rich protein APG
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4
- Phosphatidylinositol 4-kinase beta 1
- Probable beta-1,3-galactosyltransferase 8
- Tapetal oleosin GRP-19
- Probable inactive purple acid phosphatase 1
- AT2G21270 protein
Sequence:
MSRKLDSPIKTQMAVALVKSPLNGEFREFNKVGMKTPVGRRRVFVQTETGCVLGLELDRSDNAHTVKRKLQVALNFPIEESSLTFGDLVLKNDLTAVRSDSPLLLTRNNFHRSSSTPCLSPMRADLQQRRDESSPIEILGNSVSFSFVRQMAKDITKAVKKGIDPVAVNSGLGGAYYFKNSRGESVAIVKPTDEEPYAPNNPKGFVGKALGQPGLKRSVRVGETGYREVAAYLLDKEHFANVPPTALVKITHSIFNVNDGVKASKPMEKMLVSKIASLQQFIPHDYDASEHGTSNFPVSAVHRIGILDIRILNTDRHSGNLLVKKLDGDGMFGQVELVPIDHGLCLPETLEDPYFEWIHWPQASIPFSEDELKYIANLDPLGDCEMLRRELPMVREASLRVLVLCTIFLKEAAANGLCLAEIGEMMTREVRPGDEEPSEIEVVCLEAMSLIGEKDAESPRSDLGNDIEFQFDIDCEEVTDCTKKLALPLGLTFGNARGQLSKVEETTEDGEEEEEEDREEEENDRADLEKMPTIKLSMSLKSTLLGEKSQKYQKHPGARVESAYASSAHRSADEQIPSSTSFVKLSDMSEEEWTIFLEKYQELLYPAIEKRKSITLGQKQRQRLGTSCQF
Protein: Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9) (Q5ZIU9)
Organism: Gallus gallus (Chicken)
Function: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments (By similarity). Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9NUM3}. Cell membrane {ECO:0000250|UniProtKB:Q9NUM3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUM3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NUM3}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUM3}. Nucleus {ECO:0000250|UniProtKB:Q9NUM3}.
Interaction partners:
- Zinc transporter 7
- Zinc transporter ZIP13
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter 6
- Pleckstrin homology and coiled-coil domain containing D1.
- Solute carrier family 30 member 9.
- Solute carrier family 39 member 12.
- Solute carrier family 39 member 11.
Sequence:
MDDFRSICLLSLAMLVACYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHPANEMQHVMESEKVAEIAVVHEYGHDHSRLHAYIGVSLVLGFVFMLLVDQIGSSHVHSTDDPEAARSGNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIAHSHRPESTGGKGLSRLEVAALVLGCLIPLVLSIGHHH
Protein: Small ribosomal subunit protein RACK1z (Guanine nucleotide-binding protein subunit beta-like protein A) (GPB-LR) (RWD) (Receptor for activated C kinase 1A) (P49027)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the RACK1 regulatory proteins that functions in innate immunity by interacting with multiple proteins in the RAC1 immune complex. Acts as positive regulator of reactive oxygen species (ROS) production and is required for resistance against rice blast (M.grisea) infection.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18723578}. Cell membrane {ECO:0000269|PubMed:18723578}. Note=Predominantly found in the cytoplasm.
Interaction partners:
- Os10g0411700 protein
- Small ribosomal subunit protein uS9
- 40S ribosomal protein S29, putative, expressed
- Os08g0116500 protein
- 60S ribosomal protein L29
- 60S ribosomal protein L2
- Small ribosomal subunit protein eS19
- 40S ribosomal protein S30
- 40S ribosomal protein S12
- 40S ribosomal protein S12
Sequence:
MAGAQESLVLAGVMHGHNDVVTAIATPIDNSPFIVSSSRDKSLLVWDLTNPVQNVGEGAGASEYGVPFRRLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLSTGVTTRRFVGHDKDVLSVAFSVDNRQIVSASRDRTIKLWNTLGECKYTIGGDLGGGEGHNGWVSCVRFSPNTFQPTIVSGSWDRTVKVWNLTNCKLRCNLEGHGGYVNAVAVSPDGSLCASGGKDGVTLLWDLAEGKRLYSLDAGSIIHSLCFSPNRYWLCAATQDSIKIWDLESKHIVQDLKPEIPVSKNQMLYCTSLNWSADGSTLYAGYTDGTIRIYKISGFSYAG
Protein: Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) (P48303)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P21453}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21453}. Endosome {ECO:0000250|UniProtKB:P21453}. Membrane raft {ECO:0000250|UniProtKB:P21453}. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. {ECO:0000250|UniProtKB:P21453}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Sphingosine 1-phosphate receptor 4
- CD69
- RCG53912, isoform CRA_a.
- Sphingosine kinase 1
- Beta-arrestin-2
- Krueppel-like factor 2
- Apolipoprotein M
Sequence:
MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
Protein: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) (Q7ZX64)
Organism: Xenopus laevis (African clawed frog)
Function: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors. PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restricting receptor activity. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P56932}.
Interaction partners:
Sequence:
MAGVGGGNDFQWCFSQVKGAIDEDVAEADIISTVEFNCSGELLATGDKGGRVVIFQREQENKSRPHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAANFLLSTNDKTIKLWKISERDKRVEGYNLKDDDGRLRDPFRITSLRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHQTYLSADDLRVNLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPHHCHMFVYSSSKGTIRLCDMRDAALCDRHSKFFEEPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMESRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSSIMTGSYNNFFRMFDRNTRRDITLEASRESSKPRATLKPRKVCTGGKRKKDEINVDSLDFNKKILHTAWHPTDNIIAVAATNNLYIFQDKVN
Protein: E3 SUMO-protein ligase EGR2 (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (A0A0S2Z3U4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP
Protein: AT5g10730/MAJ23_90 (NAD(P)-binding Rossmann-fold superfamily protein) (Q93VH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquinone biosynthesis protein
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Polyketide cyclase / dehydrase and lipid transport protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Protein ABC transporter 1, mitochondrial
Sequence:
MRTIVSRLIRYQSSLSQIRFVSASGGGRYLSTDSNKIDEPFNVEEAETVHVPPPPTEKLLVLGGNGFVGSHVCKEALDRGLSVSSLSRSGRSSLQESWASRVTWHQGNLLSSDLLKDALEGVTSVISCVGGFGSNSYMYKINGTANINAIRAASEKGVKRFVYISAADFGLANYLLRGYYEGKRAAETELLTRFAYGGIILRPGFIYGTRSVGSMKIPLGVFGSPMEMVLQQAKPLNQLPLVGPLFTPPVNVESVAKVAVRAATDPVFPPGIVDVHGIQRYSQQKSR
Protein: Leucine-rich repeat-containing protein let-4 (SYM-1 protein) (G5EFP4)
Organism: Caenorhabditis elegans
Interaction partners:
- Leucine-rich repeat-containing protein let-4
- Cuticle collagen dpy-2
- NOmpA Homolog
- WaRThog
- LiPocalin-Related protein
- PAN domain protein
- LiPocalin-Related protein
- EGF-like domain-containing protein
- WD repeat-containing protein 44
- Papilin
Sequence:
MLLRLCVALLVLPACLAFCPKLFQNQTACSCDSTVEGPVIKCSGHDGLRMVEKLSTTTTMEVRELALENADIIEVGPKAFKTLRIKKLILSNNRIEKIHDHAFTGLENVMQELSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRISAVAPGAFAGTPLLLLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENLAVRLQENPVVCVKNGFHVLNSGEAIWLTNEANTICKGEWQAQTADLCPKAQPRPIRPVCCSNEITTTTTTTTTTTTLAPTTTTEEEKEETTETTEKVTTVGKSKKTKATTTTEEPEDDEDVYVDDDEEGTEEEEEEVSTTEKSTTTTTTTTEASKSKKVNMERFWRLSNKPSGKSPFLRHSQGNKPRYLQTTTEAPEEEDEAEYISDDGGAEESEEAETTVATTTTTEPSVKVPARIRERQRMFASNIPWMAPRTKTDSVEEEFSKDDEVETVETAEKPARH
Protein: Uncharacterized protein orf173 (Q2F972)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MKGKECKPRTSERRKRNVLQRNTIKRKWGRTKDGAHSSPIAAKVPYVSRRTRVEVNSSAELSAACFQVSSQAQNHPDDSRYSSGRGLASISTRREYGLSPRQQRGGGDLHGATRGVRNSGKRRSHMVVEEELVWAPRQWSKKFDKFMVDRYLSIPVVGADEPPSVLAAALGGL
Protein: Glucitol operon repressor (P15082)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Glucitol operon activator protein
- PTS system glucitol/sorbitol-specific EIIC component
- Arabinose 5-phosphate isomerase GutQ
- PTS system glucitol/sorbitol-specific EIIA component
- Sorbitol-6-phosphate 2-dehydrogenase
- PTS system glucitol/sorbitol-specific EIIB component
Sequence:
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQALEEKGIDVIITGESNE
Protein: Ubiquitin carboxyl-terminal hydrolase UCHL3 (EC 3.4.19.12) (PfUCHL3) (Q8IKM8)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Essential for parasite blood stage survival.
Interaction partners:
- Polyubiquitin
- Ubiquitin-60S ribosomal protein L40
- Ribosomal protein S27a, putative
- Ubiquitin
- Small ribosomal subunit protein eS30
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin-like protein nedd8 homologue, putative
Sequence:
MAKNDIWTPLESNPDSLYLYSCKLGQSKLKFVDIYGFNNDLLDMIPQPVQAVIFLYPVNDNIVSENNTNDKHNLKENFDNVWFIKQYIPNSCGTIALLHLYGNLRNKFELDKDSVLDDFFNKVNEMSAEKRGQELKNNKSIENLHHEFCGQVENRDDILDVDTHFIVFVQIEGKIIELDGRKDHPTVHCFTNGDNFLYDTGKIIQDKFIEKCKDDLRFSALAVIPNDNFDII
Protein: Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Q8CHX6)
Organism: Mus musculus (Mouse)
Function: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O43462}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O43462}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O43462}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sorting and assembly machinery component 50 homolog
- Cyclic AMP-responsive element-binding protein 3-like protein 1
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Sterol regulatory element-binding protein 2
- Sterol regulatory element-binding protein 1
- Cyclic AMP-responsive element-binding protein 3-like protein 3
- Cyclic AMP-responsive element-binding protein 3-like protein 2
- Membrane-bound transcription factor site-1 protease
- Cyclic AMP-responsive element-binding protein 3-like protein 4
- Transcription factor YY2
Sequence:
MIPVSLLVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTSIFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSPYSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSGASSSFCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR
Protein: AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C) (A6NKF2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:38231884}. Note=Interaction with NPM1 mediates ARID3C nuclear shuttling. {ECO:0000269|PubMed:38231884}.
Interaction partners:
- AT-rich interactive domain-containing protein 3A
Sequence:
MEALQKQQAARLAQGVGPLAPACPLLPPQPPLPDHRTLQAPEGALGNVGAEEEEDAEEDEEKREEAGAEEEAAEESRPGAQGPSSPSSQPPGLHPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTATPLFGLAGPPPRGAQDPALGPGPAPPATQSSPGPAQGSTSGLPAHACAQLSPSPIKKEESGIPNPCLALPVGLALGPTREKLAPEEPPEKRAVLMGPMDPPRPCMPPSFLPRGKVPLREERLDGPLNLAGSGISSINMALEINGVVYTGVLFARRQPVPASQGPTNPAPPPSTGPPSSILP
Protein: Transcription termination factor 3, mitochondrial (Mitochondrial transcription termination factor 3) (mTERF3) (mTERF domain-containing protein 1, mitochondrial) (Q8R3J4)
Organism: Mus musculus (Mouse)
Function: Binds promoter DNA and regulates initiation of transcription (By similarity). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function. Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q96E29}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX28
- Transcription termination factor 1a, mitochondrial
- FAST kinase domain-containing protein 2
- Transcription termination factor 1b, mitochondrial
- DNA-directed RNA polymerase, mitochondrial
- Mitofusin-1
- Mitofusin-2
- Dimethyladenosine transferase 1, mitochondrial
- Non-selective voltage-gated ion channel VDAC1
- Sequestosome-1
Sequence:
MALLAQQLPRRFNSVKLTSFIKAKQVTKRSARAGKAVLPGFSAQPLLSSDTSFLRRGIKTYRTLFWNRFHSASTNRTKSSAESTLLPSVAEQQERILSLESELPLEEVDDLPPLSPLQSVSEEEAIQIAAYSPLPISSFTLADYVDHSKTLQKLVQLGVDLSKIEKHPDAANLLLRLDFEKHIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLENLKTRVAYLQSKNFSKTDIARMVKNAPFLLSFSVERLDNRLGFFQKELELNVKKTRDLVVRLPRLLTGSLEPVKENMKVYHLELGFKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHNVMNIPHHIIVKFPQLFNTRVFKIKERHLFLAYLGRAQYDPAKPNYVSLDKFVSFPDKIFCKEIAKASLNDFEKFLKTL
Protein: Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Q9D700)
Organism: Mus musculus (Mouse)
Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Interaction partners:
Sequence:
MCPGNWLWASMTFMARFSRGSSRSPVRTRGSLEEMPSVHHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHNRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHFTLVEAIKKVKDHRGITPNRGFLRQLLALDRRLRQGLEA