wanglab/gogpt-training-data huggingface dataset:
Protein: Pectinesterase inhibitor 10 (Pectin methylesterase inhibitor 10) (AtPMEI10) (Q9SI74)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pectin methylesterase (PME) inhibitor involved in the maintenance of cell wall integrity in response to necrotrophic pathogens. Modulates PME activity and pectin methylesterification during infection by Botrytis cinerea and contributes to resistance against the pathogen.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:Q9STY5}.
Interaction partners:
- Pectinesterase inhibitor 12
- Pectinesterase inhibitor 5
- Pectinesterase inhibitor 1
- Pectinesterase inhibitor 2
- Probable pectinesterase/pectinesterase inhibitor 17
- Uncharacterized protein F28O16.11
- Uncharacterized protein
- soluble epoxide hydrolase
- ATPase family AAA domain-containing protein At1g05910
- Probable pectinesterase/pectinesterase inhibitor 41
Sequence:
MNILSQTQILHLSIAILLFITTSSSSLSPSSSSPSLSPSPPSSSPSSAPPSSLSPSSPPPLSLSPSSPPPPPPSSSPLSSLSPSLSPSPPSSSPSSAPPSSLSPSSPPPLSLSPSSPPPPPPSSSPLSSLSPSSSSSTYSNQTNLDYIKTSCNITLYKTICYNSLSPYASTIRSNPQKLAVIALNLTLSSAKSASKFVKNISHGGGLTRLEVVAVADCVEEIGDSVTSLQDSIRELDSINYKDSAKFEMVMSDVETWVSAALTNDDTCMDGFSLVKTAVKDLVRRHVVEVARLTSNALALINMYASTQENFS
Protein: Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) (Q15327)
Organism: Homo sapiens (Human)
Function: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}.
Interaction partners:
- Titin
- Myopalladin
- CCN family member 1
- CCN family member 2
- Y-box-binding protein 1
- Transcriptional coactivator YAP1
- Cysteine and glycine-rich protein 3
Sequence:
MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF
Protein: Vacuolar protein-sorting-associated protein 24 (DOA4-independent degradation protein 3) (ESCRT-III complex subunit VPS24) (P36095)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment oflate-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.
Subcellular location: Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosomal and other punctate structures.
Interaction partners:
- Vacuolar protein-sorting-associated protein 46
- Vacuolar protein sorting-associated protein 28
- Vacuolar protein-sorting-associated protein 25
- Vacuolar-sorting protein SNF7
- DOA4-independent degradation protein 4
- Vacuolar protein sorting-associated protein 20
- Vacuolar protein sorting-associated protein 4
- Vacuolar protein-sorting-associated protein 36
- Vacuolar-sorting protein SNF8
- Vacuolar protein-sorting-associated protein 60
Sequence:
MDYIKKAIWGPDPKEQQRRIRSVLRKNGRNIEKSLRELTVLQNKTQQLIKKSAKKNDVRTVRLYAKELYQINKQYDRMYTSRAQLDSVRMKIDEAIRMNTLSNQMADSAGLMREVNSLVRLPQLRNTMIELEKELMKSGIISEMVDDTMESVGDVGEEMDEAVDEEVNKIVEQYTNEKFKNVDQVPTVELAANEEEQEIPDEKVDEEADRMVNEMRERLRALQN
Protein: Membrane magnesium transporter (Q9VJ25)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU367002}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367002}. Early endosome membrane {ECO:0000256|RuleBase:RU367002}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367002}.
Interaction partners:
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 7
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 8/9 homolog
- GH11935p
Sequence:
MGSKLFNKLLLIAGFASLAHAAFSAAHHRTYLRLTEQEWNSLPLDIILQTVISLVIVIYNIIEIVGNFKEIRATVDMQQKTWDTLGNFPSFYSFNHRGRALNPGYTPPE
Protein: Linear ubiquitin E3 ligase, isoform D (Linear ubiquitin E3 ligase, isoform K) (E1JHA3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTTHQLLNKNVRTMPSWVMEANDRIGPKPPPTPPNGVAGGLPKAPALPPKAKSTPEPDYEIIEFSSQQYSNEPMKTTVIRTKTPDNKLKCTLCGSQNPWVTCAECAGQIFCASCDDMFHKHPKRKQHMRKAVEQGTPPIPPKAQAGGGAPPPVAPPRRSKRGLLTPFLGRKDQVRHCTIS
Protein: Metaxin-1 (Mitochondrial outer membrane import complex protein 1) (Q13505)
Organism: Homo sapiens (Human)
Function: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion outer membrane {ECO:0000250}.
Interaction partners:
- Sorting and assembly machinery component 50 homolog
- Metaxin-2
- MICOS complex subunit MIC60
- Mitochondrial import receptor subunit TOM40 homolog
- DnaJ homolog subfamily C member 11
- MICOS complex subunit MIC25
- MICOS complex subunit MIC10
- MICOS complex subunit MIC19
- Thrombospondin-3
- Tripartite motif-containing protein 46
Sequence:
MLLGGPPRSPRSGTSPKGPWSSTGHVQFGKSPQTWPRRTRPRSPEPAAPSGVRGSTWTRRRDSPRRAGPTALSRYVGHLWMGRRPPSPEARGPVPRSSAASRARRSLASPGISPGPLTATIGGAVAGGGPRQGRAEAHKEVFPGQRVGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKISNPWQSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYFPWDGAEVPPQRQTPAGPETEEEPYRRRNQILSVLAGLAAMVGYALLSGIVSIQRATPARAPGTRTLGMAEEDEEE
Protein: Phosphoprotein (Protein P) (Protein M1) (P22363)
Organism: Rabies virus (strain CVS-11) (RABV)
Function: Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body.
Subcellular location: [Phosphoprotein]: Virion. Host cytoplasm.; SUBCELLULAR LOCATION: [Isoform P2]: Host cytoplasm.; SUBCELLULAR LOCATION: [Isoform P3]: Host nucleus.; SUBCELLULAR LOCATION: [Isoform P4]: Host nucleus.; SUBCELLULAR LOCATION: [Isoform P5]: Host nucleus.
Interaction partners:
Sequence:
MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDNLPEDMKRLHLDDEKSSNLGEMVRVGEGKYREDFQMDEGEDPNLLFQSYLDNVGVQIVRQMRSGERFLKIWSQTVEEIVSYVTVNFPNPPRRSSEDKSTQTTGRELKKETTSAFSQRESQPSKARMVAQVAPGPPALEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLKMNLDDIVKEAKNVPGVTRLAHDGSKIPLRCVLGWVALANSKKFQLLVEADKLSKIMQDDLNRYTSC
Protein: Molybdate/tungstate import ATP-binding protein WtpC (EC 7.3.2.6) (O30144)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Function: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system (Probable).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Molybdate/tungstate-binding protein WtpA
- Molybdate/tungstate transport system permease protein WtpB
- Glutamine ABC transporter, permease protein
Sequence:
MFLKVRAEKRLGNFRLNVDFEMGRDYCVLLGPTGAGKSVFLELIAGIVKPDRGEVRLNGADITPLPPERRGIGFVPQDYALFPHLSVYRNIAYGLRNVERVERDRRVREMAEKLGIAHLLDRKPARLSGGERQRVALARALVIQPRLLLLDEPLSAVDLKTKGVLMEELRFVQREFDVPILHVTHDLIEAAMLADEVAVMLNGRIVEKGKLKELFSAKNGEVAEFLSARNLLLKVSKILD
Protein: Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) (Q6P158)
Organism: Homo sapiens (Human)
Function: Probable ATP-binding RNA helicase.
Interaction partners:
- ATP-dependent RNA helicase DDX54
- La-related protein 7
- Small ribosomal subunit protein uS2
Sequence:
MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGGGGGGGGGGGGGNRKASSRIWDDGDDFCIFSESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGLSGEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQISLDECMEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRIERSVDDSHLNAIEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASESEESDEDDGPAPVIVENESYVNLKKKISKRYDWQAKSVHAENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISTIVKLVTTQ
Protein: Ubiquitin-activating enzyme E1-like (Polymerase-interacting protein 2) (SMT3-activating enzyme subunit 2) (P52488)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP-dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1.
Subcellular location: Nucleus.
Interaction partners:
- SUMO-conjugating enzyme UBC9
- DNA damage tolerance protein RHC31
- Ubiquitin-like protein SMT3
- Ubiquitin-like-specific protease 2
- Ubiquitin-like-specific protease 1
- E3 SUMO-protein ligase SIZ2
- E3 SUMO-protein ligase SIZ1
- E3 SUMO-protein ligase MMS21
- UV excision repair protein RAD23
- NEDD8-conjugating enzyme UBC12
Sequence:
MPRETSLVTIIGEDSYKKLRSSRCLLVGAGGIGSELLKDIILMEFGEIHIVDLDTIDLSNLNRQFLFRQKDIKQPKSTTAVKAVQHFNNSKLVPYQGNVMDISTFPLHWFEQFDIIFNALDNLAARRYVNKISQFLSLPLIESGTAGFDGYMQPIIPGKTECFECTKKETPKTFPVCTIRSTPSQPIHCIVWAKNFLFNQLFASETSGNEDDNNQDWGTDDAEEIKRIKQETNELYELQKIIISRDASRIPEILNKLFIQDINKLLAIENLWKTRTKPVPLSDSQINTPTKTAQSASNSVGTIQEQISNFINITQKLMDRYPKEQNHIEFDKDDADTLEFVATAANIRSHIFNIPMKSVFDIKQIAGNIIPAIATTNAIVAGASSLISLRVLNLLKYAPTTKYTDLNMAFTAKASNLSQNRYLSNPKLAPPNKNCPVCSKVCRGVIKLSSDCLNKMKLSDFVVLIREKYSYPQDISLLDASNQRLLFDYDFEDLNDRTLSEINLGNGSIILFSDEEGDTMIRKAIELFLDVDDELPCNTCSLPDVEVPLIKANNSPSKNEEEEKNEKGADVVATTNSHGKDGIVILDDDEGEITIDAEPINGSKKRPVDTEISEAPSNKRTKLVNEPTNSDIVELD
Protein: Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 (EC 2.7.10.1) (EC 2.7.11.1) (Protein EVERSHED) (Protein SUPPRESSOR OF BIR1-1) (Q9SKB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Acting as a counterplayer of BIR1, promotes the activation of plant defense and cell death. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. Functions as an inhibitor/regulator of abscission, probably by regulating membrane trafficking during abscission.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20081191, ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000269|PubMed:20081191, ECO:0000305|PubMed:17644812}.
Interaction partners:
- Receptor like protein 23
- Indole-3-acetic acid-amido synthetase GH3.2
- CF9 protein
- Lipase-like PAD4
- Protein EDS1
- ADP-ribosylation factor GTPase-activating protein AGD5
- Stromal cell-derived factor 2-like protein
- LysM domain-containing GPI-anchored protein 3
- DnaJ protein ERDJ3B
- Calreticulin-3
Sequence:
MAVPTGSANLFLRPLILAVLSFLLLSSFVSSVEWLDIDSSDLKALQVIETELGVNSQRSSASDVNPCGRRGVFCERRHSATTGEYVLRVTRLVYRSRSLTGTISPVIGMLSELKELTLSNNQLVNAVPVDILSCKQLEVLDLRKNRFSGQIPGNFSSLSRLRILDLSSNKLSGNLNFLKNLRNLENLSVANNLFSGKIPEQIVSFHNLRFFDFSGNRYLEGPAPVMSSIKLQTSPHQTRHILAETPTSSPTNKPNNSTTSKAPKGAPKPGKLKKKKKKSKKKKVAAWILGFVVGAIGGTISGFVFSVLFKLIIQAIRGSEKPPGPSIFSPLIKKAEDLAFLENEEALASLEIIGRGGCGEVFKAELPGSNGKIIAVKKVIQPPKDADELTDEDSKFLNKKMRQIRSEINTVGHIRHRNLLPLLAHVSRPECHYLVYEYMEKGSLQDILTDVQAGNQELMWPARHKIALGIAAGLEYLHMDHNPRIIHRDLKPANVLLDDDMEARISDFGLAKAMPDAVTHITTSHVAGTVGYIAPEFYQTHKFTDKCDIYSFGVILGILVIGKLPSDEFFQHTDEMSLIKWMRNIITSENPSLAIDPKLMDQGFDEQMLLVLKIACYCTLDDPKQRPNSKDVRTMLSQIKH
Protein: Tropomyosin-2 (P40414)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cell morphogenesis. Binds to F-actin and stabilizes the actin filaments.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Actin
- Tropomyosin-1
- Myosin-1
- Fimbrin
- BNI1-related protein 1
- Cofilin
- Ras GTPase-activating-like protein IQG1
- Myosin light chain 1
- SWI5-dependent HO expression protein 3
- Myosin light chain 2
Sequence:
MEKIKEKLNSLKLESESWQEKYEELREQLKELEQSNTEKENEIKSLSAKNEQLDSEVEKLESQLSDTKQLAEDSNNLRSNNENYTKKNQDLEQQLEDSEAKLKEAMDKLKEADLNSEQMGRRIVALEEERDEWEKKCEEFQSKYEEAQKELDEIANSLENL
Protein: Zinc finger protein 830 (Coiled-coil domain-containing protein 16) (Q96NB3)
Organism: Homo sapiens (Human)
Function: May play a role in pre-mRNA splicing as component of the spliceosome. Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:25599396}. Chromosome {ECO:0000250|UniProtKB:Q8R1N0}. Nucleus speckle {ECO:0000250|UniProtKB:Q8R1N0}. Note=Excluded from nucleolus. {ECO:0000250|UniProtKB:Q8R1N0}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase E
- Splicing factor 3B subunit 2
- Pre-mRNA-processing-splicing factor 8
- Poly
- RNA helicase aquarius
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor SYF1
- SNW domain-containing protein 1
- Crooked neck-like protein 1
- Pre-mRNA-splicing factor ISY1 homolog
Sequence:
MASSASARTPAGKRVINQEELRRLMKEKQRLSTSRKRIESPFAKYNRLGQLSCALCNTPVKSELLWQTHVLGKQHREKVAELKGAKEASQGSSASSAPHSVKRKAPDADDQDVKRAKATLVPQVQPSTSAWTTNFDKIGKEFIRATPSKPSGLSLLPDYEDEEEEEEEEEGDGERKRGDASKPLSDAQGKEHSVSSSREVTSSVLPNDFFSTNPPKAPIIPHSGSIEKAEIHEKVVERRENTAEALPEGFFDDPEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGRLDRQIGEIDEQIECYRRVEKLRNRQDEIKNKLKEILTIKELQKKEEENADSDDEGELQDLLSQDWRVKGALL
Protein: Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Q8K221)
Organism: Mus musculus (Mouse)
Function: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:P53365}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P53365}.
Interaction partners:
- ADP-ribosylation factor-like protein 1
- ADP-ribosylation factor 1
- ADP-ribosylation factor 6
Sequence:
MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ
Protein: Protein EMBRYONIC FLOWER 1 (Q9LYD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription repressor that regulates phase transition during shoot, flower and seeds development. Controls leaves development, shoot architecture and flowering by delaying both the vegetative to reproductive transition and flower initiation. Participates in polycomb group (PcG) protein complex-mediated (including EMF2) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development. Required for histone methylation or for maintaining a stable histone methylation (e.g. H3K27me3) pattern of repressed target genes (including genes involved in salt stress response and flower development); this repression is counteracted by ULT1. Can bind non specifically DNA (both double- and single-stranded) and RNA.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:18281509}. Note=Follow a speckle-like pattern. {ECO:0000269|PubMed:18281509}.
Interaction partners:
- Putative E3 ubiquitin-protein ligase RING1a
- Chromo domain-containing protein LHP1
- Putative E3 ubiquitin-protein ligase RING1b
- Polycomb group protein EMBRYONIC FLOWER 2
- Lysine-specific demethylase JMJ14
- At5g64360
- E3 ubiquitin-protein ligase RING1
- Histone H3.1
- Histone H3-like 5
- Histone H3-like 2
Sequence:
MGSSIKINSISIDLAGAANEIDMVKCDHFSMRGFVAETRERDLRKCWPFSEESVSLVDQQSYTLPTLSVPKFRWWHCMSCIKDIDAHGPKDCGLHSNSKAIGNSSVIESKSKFNSLTIIDHEKEKKTDIADNAIEEKVGVNCENDDQTATTFLKKARGRPMGASNVRSKSRKLVSPEQVGNNRSKEKLNKPSMDISSWKEKQNVDQAVTTFGSSEIAGVVEDTPPKATKNHKGIRGLMECDNGSSESINLAMSGLQRRKSRKVRLLSELLGNTKTSGGSNIRKEESALKKESVRGRKRKLLPENNYVSRILSTMGATSENASKSCDSDQGNSESTDSGFDRTPFKGKQRNRRFQVVDEFVPSLPCETSQEGIKEHDADPSKRSTPAHSLFTGNDSVPCPPGTQRTERKLSLPKKKTKKPVIDNGKSTVISFSNGIDGSQVNSHTGPSMNTVSQTRDLLNGKRVGGLFDNRLASDGYFRKYLSQVNDKPITSLHLQDNDYVRSRDAEPNCLRDFSSSSKSSSGGWLRTGVDIVDFRNNNHNTNRSSFSNLKLRYPPSSTEVADLSRVLQKDASGADRKGKTVMVQEHHGAPRSQSHDRKETTTEEQNNDDIPMEIVELMAKNQYERCLPDKEEDVSNKQPSQETAHKSKNALLIDLNETYDNGISLEDNNTSRPPKPCSSNARREEHFPMGRQQNSHDFFPISQPYVPSPFGIFPPTQENRASSIRFSGHNCQWLGNLPTVGNQNPSPSSFRVLRACDTCQSVPNQYREASHPIWPSSMIPPQSQYKPVSLNINQSTNPGTLSQASNNENTWNLNFVAANGKQKCGPNPEFSFGCKHAAGVSSSSSRPIDNFSSESSIPALHLLSLLDPRLRSTTPADQHGNTKFTKRHFPPANQSKEFIELQTGDSSKSAYSTKQIPFDLYSKRFTQEPSRKSFPITPPIGTSSLSFQNASWSPHHQEKKTKRKDTFAPVYNTHEKPVFASSNDQAKFQLLGASNSMMLPLKFHMTDKEKKQKRKAESCNNNASAGPVKNSSGPIVCSVNRNPADFTIPEPGNVYMLTGEHLKVRKRTTFKKKPAVCKQDAMKQTKKPVCPPTQNA
Protein: Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3) (Q7Z3Q1)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:26631267, ECO:0000269|PubMed:35862544, ECO:0000269|PubMed:36741448}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR
Protein: 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase (2-dehydro-3-deoxyglucono/galactono-kinase) (EC 2.7.1.178) (2-keto-3-deoxy-galactonokinase) (2-keto-3-deoxygluconokinase) (3-deoxy-2-oxo-D-gluconate kinase) (KDG kinase) (KDGal kinase) (Q97U29)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3-deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively.
Interaction partners:
- D-gluconate/D-galactonate dehydratase
- 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
- NAD
- Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
- gluconate dehydratase
- 1-
- Glyceraldehyde-3-phosphate dehydrogenase
- Enolase
Sequence:
MVDVIALGEPLIQFNSFNPGPLRFVNYFEKHVAGSELNFCIAVVRNHLSCSLIARVGNDEFGKNIIEYSRAQGIDTSHIKVDNESFTGIYFIQRGYPIPMKSELVYYRKGSAGSRLSPEDINENYVRNSRLVHSTGITLAISDNAKEAVIKAFELAKSRSLDTNIRPKLWSSLEKAKETILSILKKYDIEVLITDPDDTKILLDVTDPDEAYRKYKELGVKVLLYKLGSKGAIAYKDNVKAFKDAYKVPVEDPTGAGDAMAGTFVSLYLQGKDIEYSLAHGIAASTLVITVRGDNELTPTLEDAERFLNEFKT
Protein: NADPH-dependent alpha-keto amide reductase (AKR-E) (EC 1.2.1.-) (YKAR) (Q07551)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Reduces aromatic alpha-keto amides, aliphatic and aromatic alpha-keto esters, but not beta-keto esters.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YNL134C
Sequence:
MSFHQQFFTLNNGNKIPAIAIIGTGTRWYKNEETDATFSNSLVEQIVYALKLPGIIHIDAAEIYRTYPEVGKALSLTEKPRNAIFLTDKYSPQIKMSDSPADGLDLALKKMGTDYVDLYLLHSPFVSKEVNGLSLEEAWKDMEQLYKSGKAKNIGVSNFAVEDLQRILKVAEVKPQVNQIEFSPFLQNQTPGIYKFCQEHDILVEAYSPLGPLQKKTAQDDSQPFFEYVKELSEKYIKSEAQIILRWVTKRGVLPVTTSSKPQRISDAQNLFSFDLTAEEVDKITELGLEHEPLRLYWNKLYGKYNYAAQKV
Protein: Mutant prune (Prune protein) (Q24465)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCFLRFLAQARGTLGRHLAEASPVAWAAAPDVSGRKLHLVMGNESCDLDSAVSAVTLAFVYAASSGARLCTYTEHSSPGLPVENRGGPLVCEMWDCRARVALPRRYSPGSGPGCERYSRGPPCKPWAPNVTEILDHRPLEDSSPSFKQLPTLCQLDIDASVGSCATLVAQRYLAEDQPRSTSVAQLLHATIVLDTINFAPAAKRYGPKDEAMVQKLESELNRKDAQRSSLFDELVAARADISKLTLTEVLRKDMKVLQTDRQVVPLAGMPILVRDFVEKSGAEKAVREFGVESNLLVILGMYVSPADGQVQRDLALISLSGQGQFVQRVQQALMESNDPKLELRPHEVDTRFMGGCFLRQHNVQATRKHILPIVKRALLEWEADHACDCDEVYFFKEKPQLGLS