wanglab/gogpt-training-data huggingface dataset:
Protein: Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) (Q8CG19)
Organism: Mus musculus (Mouse)
Function: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q14766}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q14766}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-3 proprotein
- Transforming growth factor beta-2 proprotein
- Fibrillin-1
- Thrombospondin-1
- Fibronectin
- ADAMTS-like protein 2
- Integrin alpha-V
- Latent-transforming growth factor beta-binding protein 3
- Latent-transforming growth factor beta-binding protein 2
Sequence:
MAGAWLRWGLLLWAGLLAWSAHGRVRRITYVVRPGPGLPAGALPLAGPPRTFNVALDARYSRSSTAASSRALAGPPAERTRRTSQPGGAALPGLRSPLPPEPARPGGPSRQLHSKAGAQTAVTRFAKHGRQVVRSQVQQDAQSAGGSRLQVQQKQQLQGINVCGGQCCHGWSKPPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGSKGKACEITAAQDTMPPAFGGQNPGSSWAPLEQAAKHTSTKKADTLPRVSPVAQMTLTLKPKPSMGLSQQIHPQVAPLSSQNVMIRHGQTQEYLLKPKYFPAPKVVSAEQSTEGSFSLRYGQEQGTAPFQVSNHTGRIKVVFTPSICKVTCTKGNCQNSCQKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVLGASMPKLYQHAQQQGKALGSHVIHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDSPGGQKVKEAQPGQSQVSYQGLPVQKTQTVHSTYSHQQLIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPVISEEKGPCYRLVSPGRHCMHPLSVHLTKQICCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHQHIGKEAVYVKPKNTQPVAKSTHPPPLPAKEEPVEALTSSWEHGPRGAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQLRKCVDIDECAQVRHLCSQGRCENTEGSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSFRCTCGQGYQLSAAKDQCEDIDECEHHHLCSHGQCRNTEGSFQCVCNQGYRASVLGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGFQLNDNKGCQDINECAQPGLCGSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRVTEDSGVDRQPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGEEICKNGYCLNTQPGYECYCKQGTYYDPVKLQCFDMDECQDPNSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSYKCLCLPGYIPSDKPNYCTPLNSALNLDKESDLE
Protein: Met4p (Q5A5T7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ubiquitin-binding SDF ubiquitin ligase complex subunit
- Transcriptional regulator CBF1
- C2H2-type domain-containing protein
Sequence:
MSDEPTSAALLEQLVYIDNYINGNASTATDSSTATPNLDMDGQLSLDLAAFADDSFIFPDEDKKHNNDNSNSDSNWNIQEFDNQEIGSSHSHSHSQSHNHHHHHHNHVEDLNNNNILRQQEFQSHLPSLTHQPHHLSTSLLASQSHAHLTTQEPATIDLMNPSSFVNLTDLPKFPVPPGAKSSLFDAGLSQNQIDLLSALVAQHQASLGNPIPSVQSPNATATTTTTPLSVSPAELPLRINNSITTVAPITTTNVNVNANGHLHRSSVSSQSSNTTMALLDPIPSSSSVSPSSVTGGNTQGFAAELDKKRRNTAASARFRFKKKLREKQMETKINNLEDLIVNLENQLNNLEMENKLLRNLIIEKGTQKSDDEVKLLREKARLNQ
Protein: T cell receptor beta chain MC.7.G5 (TR beta chain TRBV25-1*01J2S3*01C2*01) (MC.7.G5 TRB) (P0DTU4)
Organism: Homo sapiens (Human)
Function: The beta chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells even stressed or infected by bacteria. Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:31959982}.
Interaction partners:
Sequence:
MTIRLLCYMGFYFLGAGLMEADIYQTPRYLVIGTGKKITLECSQTMGHDKMYWYQQDPGMELHLIHYSYGVNSTEKGDLSSESTVSRIRTEHFPLTLESARPSHTSQYLCASSEARGLAEFTDTQYFGPGTRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG
Protein: Geranylgeranyl pyrophosphate synthase (O61539)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEELNIILQKTKDKSTQKEQDEILLQPFTYIQQIPGKQFRSELALAFNHWLLIPGEKLAQIGDIVQMLHNSSLLIDDIEDNSILRRGVPVAHSIYGVASTINAANYALFLALEKVQQLDHPEATKVYTEQLLELHRGQGMEIYWRDSFTCPSESDYKLMTVRKTGGLFMLAIRLMQLFSSNKEDYSKLTAILGLYFQIRDDYCNLSLKEYTENKSFAEDLTEGKFGFPVIHAVRTQKQDKQVLHILRQRTHDIEVKKYCITLLEKLGSFQYTRKVLESLDAEARSEVARLGSNPYMDRLLNKLLSWKTSDSASITQSNQINHNNVSRSSPNQNTFNCN
Protein: Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122) (P14784)
Organism: Homo sapiens (Human)
Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Interleukin-2
- Cytokine receptor common subunit gamma
- Interleukin-15 receptor subunit alpha
- Interleukin-2 receptor subunit alpha
- Interleukin-15
- Tyrosine-protein kinase JAK1
- Signal transducer and activator of transcription 5A
- Tyrosine-protein kinase JAK3
- Signal transducer and activator of transcription 5B
- Interleukin-7
Sequence:
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV
Protein: RH13070p (Q8SX15)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLLQKLSRSGVPMASLTCRSRMPMVIRLISGNTEKPAEESTPAVNTETAEIGSSKGGFARAFDKYTAPATPPQLPEDNQTFASLLRNSKLIDLDNAEGKVVSGKIFHVVGDDLYIDFGWKFHCVCSRPTRNASDYVRGARVRLRIKDLELSTKFQGSSKDITILEADCHLLGLLSTPTRQSTAKTTPKIEDIL
Protein: Uncharacterized protein (Q38EM0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPCTSLCFLLLCCYVISPSPHSLLLFFFLFLQRHSNMGKNGLLHSHLSPLFTQLIRLATPSVILFPFIGLYARIILFFYCWLVYVFTSLCFYIILYYTHIYIYIYIFPPSRLVGMKNKAASRRDEKLIKGTNIIVKNVSLIDKHRNDPQALLHSIEADDAVELRWWRNALRPEANLIEPAVAYLQGIKVIRPATNFNTFDIKKARLRRLEKQEIERKKCLERRKRDVAPTAAMKASANPYRVPRSGGYIKQKDDRIIQRGEKTKKAAKKDIKESGGKTQRHKSNGEKGKLQKIGKGL
Protein: Protein mab-21-like 2 (Q8UUZ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:15183718, ECO:0000269|PubMed:25719200}. Cytoplasm {ECO:0000269|PubMed:25719200}. Note=Predominantly localizes to the nucleus, with some cytoplasmic localization (PubMed:25719200). {ECO:0000269|PubMed:25719200}.
Interaction partners:
Sequence:
MIATQAKLVYQLNKYYNERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEGMEVIAPNEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFAEAENRLLMSGCRKKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALETAAKQTWRLAREILTNAKSLDKL
Protein: Regulatory protein SoxS (P0A9E2)
Organism: Escherichia coli (strain K12)
Function: Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.
Subcellular location: Cytoplasm.
Interaction partners:
- Redox-sensitive transcriptional activator SoxR
- DNA-directed RNA polymerase subunit alpha
- Arabinose operon regulatory protein
- RNA polymerase sigma factor RpoD
- DNA-directed RNA polymerase subunit beta
- HTH-type transcriptional regulator AcrR
- Superoxide dismutase
- DNA-binding transcriptional dual regulator OxyR
- Multiple antibiotic resistance protein MarR
- Outer membrane protein TolC
Sequence:
MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (A0A494BZU6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIVSCRFTLRMRST
Protein: Probable pyridoxal 5'-phosphate synthase subunit pdx2 (EC 4.3.3.6) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) (Q54J48)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of pdx1.
Interaction partners:
- Probable pyridoxal 5'-phosphate synthase subunit pdx1
- Pyridoxine-5'-phosphate oxidase
- Pyridoxal kinase
- GMP synthase
- Ribokinase
- Probable transaldolase
- Ribose-5-phosphate isomerase
- Phosphoglucomutase-1
- Ribose-phosphate pyrophosphokinase C
- Probable phosphoglucomutase-2
Sequence:
MEELIEENNIKIGVLALQGGFKEHVEMVKSIKHCFSECENKYKYSIIVQEVKSVSDIKKLNPHGIILPGGESTSMAIIASSNNDGENIFTFLKEYIKQGNFIWGTCAGSIMLSNNVDGQKVGGQSLIGGLDVLISRNYFGRQIDSFETKINLNLKFSKNNNNSILLENFEAIFIRAPAILDVIDKENVEIIGEYIVTKKDGTKEKVITAVKQNNIIASVFHPELTNDNRFHQYFVQLVLNNHLIKIKI
Protein: Claudin-16 (Paracellin-1) (Q925N4)
Organism: Mus musculus (Mouse)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity).
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:28028216}. Cell membrane {ECO:0000269|PubMed:28028216}; Multi-pass membrane protein {ECO:0000255}. Note=Cotrafficks with CLDN19 from ER to tight junctions. {ECO:0000250|UniProtKB:Q9Y5I7}.
Interaction partners:
- Claudin-19
- Tight junction protein 1
- Claudin-5
- Claudin-23
- Claudin-17
- Claudin-6
- Claudin-3
- Claudin-1
- Claudin-13
- Claudin-8
Sequence:
MKDLLQYAACFLAIFSTGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSIYAEHPLKLVVTRALMITADILAGFGFITLLLGLDCVKFLPDDPQIKVRLCFVAGTTLLIAGTPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGALLTCCLYLFKDVGPERNYPYAMRKPYSTAGVSMAKSYKAPRTETAKMYAVDTRV
Protein: Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog) (P04628)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 6
- Low-density lipoprotein receptor-related protein 5
- Frizzled-1
- Frizzled-8
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-7
- Frizzled-10
- Frizzled-2
- Secreted frizzled-related protein 1
- Frizzled-4
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
Protein: Probable fatty acyl-CoA reductase 4 (EC 1.2.1.84) (Q9LXN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. Catalyzes specifically the formation of C18:0 and C20:0 fatty alcohols. Provides the fatty alcohols required for synthesis of suberin in roots, seed coat and wound-induced leaf tissue. Provides the fatty alcohols required for synthesis of alkyl hydroxycinnamates in root waxes.
Interaction partners:
- Wax ester synthase/diacylglycerol acyltransferase 1
- Omega-hydroxypalmitate O-feruloyl transferase
- Fatty alcohol:caffeoyl-CoA acyltransferase
- Cytochrome P450 86B1
- Glycerol-3-phosphate acyltransferase 5
- Cytochrome P450 86A1
- 3-ketoacyl-CoA synthase 2
- ABC transporter G family member 6
- ABC transporter G family member 20
- Probable 3-ketoacyl-CoA synthase 21
Sequence:
MDSNCIQFLHDKTILVTGVPGFLAKVFVEKILRIQPKVKKLFLLLRAADNESAMQRFHSEVLEKDLFRVLKNALGDENLKAFITEKVVPIPGDISVDNLGVKGSDLLQHMWNEIDIIVNVAATTNFDERYDVGLSVNTFGPLNVLNFAKKCVKGQLLLHVSTAYVRGEKSGLLHEKTFHMGETLNGHRKLVIETEMELMKQKLKELQKQNCSEEEISQSMKDLGMSRAKLHGWPNTYVFTKSMGEMLLGNYRENLPIVIIRPTMITSTFSEPFPGWIEGLRTIDSVIVAYGKGRLKCFLADPNSVLDLIPVDMVANAMVTAAAIHAGKLGSQTVYHVGSSCKNPITFEQIHDLAASYFTKNPLVRRDGSSILVSKGTILSTMAQFSFYMTLRYKLPLQMLRLIYVIYPWWNGNKYKDIDRKIKLAMRLVDLYRPYVLFKGIFDDTNTEKLRLKRKEINKEMYGLFEFDPKSIDWEDYMTTIHIPGLITYVLKK
Protein: COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) (Q9ERR2)
Organism: Rattus norvegicus (Rat)
Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10918053}.
Interaction partners:
- COMM domain containing 2
- COMM domain containing 10
- COMM domain containing 9
- COMM domain containing 8
- COMM domain containing 4
- Coiled-coil domain-containing protein 22
- COMM domain-containing protein 1
- COMM domain-containing protein 6
- COMM domain containing 7
- Coiled-coil domain-containing protein 93
Sequence:
MSALGAAAPYLHHPADSHSGRVSFLGSQPSPEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVEQLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQEELQELGIPQDLIGDLASLAFGSQRPLLDSVAQQQGSSLPHVSYFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELEKKCERKLQD
Protein: YscO (Q93KT7)
Organism: Yersinia enterocolitica
Interaction partners:
Sequence:
MIRRLHRVKVLRVERAEQAIKTQQACLQAAHRRHQEAVQTSQDYHLWRIDEEQRLFDQRKNTTLNCKDLEKWQRQIASLREKEANYELECAKLLERLANERERLTSCQKTLQQARHKENKFLELVRREDEDELNQQHYQEEQEQEEFLQHHRNA
Protein: Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) (P55262)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P55263}.
Interaction partners:
Sequence:
MAAAEEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEEKHKELFDELVRKFKVEYHAGGSTQNSIKVAQWMIQKPHKAATFFGCIGIDKFGEILKSKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLVANLAAANCYKKEKHLDLENNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRIFTLNLSAPFISQFFKESLMEVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALAKVNSKRPRTVVFTQGRDDTVVATENEVMAFAVLDQNQKEIIDTNGAGDAFVGGFLSQLVYNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
Protein: Uncharacterized membrane protein YLR046C (Q12253)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MATHTSKRRIHRWENNELSEENSTIIYFPARGLMWTHFPFVLGICLEFVGYVLKIVFINSPSISTFIAQSVLLLIAPSLYALSIFMLFSKMARLILMEAYMLIPAKFSTVSFVVADMIGRVLQAVGGGLLSSWNSRNTGRILIIVGLFIQIFCYTFLTFSQLFLHYKMKATPSKIVRDSNEWFQYNFILLAGILLVNGRTIVRVVQFLMGLQSYIGQHEWCLYVFDTVLMFLLPLIFLATFRARNLFKLQDKSVNIQLNKLLDKESVSED
Protein: Hercynylcysteine sulfoxide lyase (EC 4.4.1.-) (Ergothioneine biosynthesis protein 2) (PLP-binding cysteine desulfurase) (PLP-dependent C-S lyase) (O94431)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine by cleaving the cysteine residue at the sulfur atom, the last step in the biosynthesis pathway of ergothioneine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:24828577}.
Interaction partners:
- Ergothioneine biosynthesis protein 1
- Iron sulfur cluster assembly protein 1, mitochondrial
- Uncharacterized aminotransferase C777.03c
- Uncharacterized protein C11D3.10
- Frataxin homolog, mitochondrial
- Protein isd11
- NifU-like protein C1709.19c
Sequence:
MAENNVYGHEMKKHFMLDPDYVNVNNGSCGTESLAVYNKHVQLLKEAQSKPDFMCNAYMPMYMEATRNEVAKLIGADSSNIVFCNSATDGISTVLLTFPWEQNDEILMLNVAYPTCTYAADFAKNQHNLRLDVIDVGVEIDEDLFLKEVEQRFLQSKPRAFICDILSSMPVILFPWEKVVKLCKKYNIVSIIDGAHAIGHIPMNLANVDPDFLFTNAHKWLNSPAACTVLYVSAKNHNLIEALPLSYGYGLREKESIAVDTLTNRFVNSFKQDLPKFIAVGEAIKFRKSIGGEEKIQQYCHEIALKGAEIISKELGTSFIKPPYPVAMVNVEVPLRNIPSIETQKVFWPKYNTFLRFMEFKGKFYTRLSGAVYLEESDFYYIAKVIKDFCSL
Protein: Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) (Q9Y2H0)
Organism: Homo sapiens (Human)
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- SH3 and multiple ankyrin repeat domains protein 3
- Disks large-associated protein 2
- Disks large homolog 4
- Disks large homolog 3
- SH3 and multiple ankyrin repeat domains protein 2
- Disks large homolog 2
- SH3 and multiple ankyrin repeat domains protein 1
- Disks large-associated protein 3
Sequence:
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPSHAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGRRAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPPPAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIPCRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCISQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLPSSSCLVAYKKTPPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQSGLSNSSDSLDSSTRPPSVTRGGVAPAPEAPEPPPKHAALKSEQGTLTSSESHPEAAPKRKLSSIGIQVDCIQPVPKEEPSPATKFQSIGVQVEDDWRSSVPSHSMSSRRDTDSDTQDANDSSCKSSERSLPDCTPHPNSISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPGACRRDGYWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVETPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAKRAASVRQNSATESADSIEIYVPEAQTRL
Protein: Tricarboxylate transport protein, mitochondrial (Citrate carrier) (CIC) (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein) (P32089)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate. In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:12488104}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Citrate synthase, mitochondrial
- ATP-citrate synthase
- Large ribosomal subunit protein mL40
- Transport and golgi organization 2 homolog
- DNA polymerase epsilon subunit
- Developmentally-regulated GTP-binding protein 1
- Progranulin
- STING ER exit protein
- UPF0235 protein C15orf40 homolog
Sequence:
MAAPRAPRALTAAAPGSGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERANPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSRRGLLCGLGAGVAEAVVVVCPMETVKVKFIHDQTSSNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYQGDNPNKPMNPLITGVFGAVAGAASVFGNTPLDVIKTRMQGLEAHKYRNTLDCGVQILKNEGPKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD
Protein: Sig5 (Q84JN3)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MASTVTTPSRPVSAGCHRRSPRRSAPVVLSLGGGPRRRTPSSTSCSALASPAKQGTAKLPPPQPTASRTAAADAERERERTDYNEVAAALESIYKLSPAVVEEKDADEEDEKSKQTKRKRKGRVGRSRNATVTVRSSRRRRRGQRMDLGKRVEMRRREEEEGGGGAGKVEDEERGFEEMLLREHAVSTDMGSLDWKRMKIPPVLTSAQSIRLFRIMQPMKAIMEMKENLENEVQSEPNDAQLAEAMNMSVLQMRRHLEVGRAARNKLIKHNLRLVLYTINKYYPDMSNDERFDDICQAGANGLITAIDRFEPKRGFRISTYALFWIRHSIVRAITLSNFTRFPFAMESERQEIHRAREELAFELGRAPTEEEVMKKVGLSPARYRDVVRMTRPTYSLHARNRVTQEELINEVTDDDAIGVDTSSHNTLLRLAIDDLLDSLKPKESVVIRQRFGLDGRGKRTLSEIAGNLNISREMVRKYELKALMKLKHPTRVEYLRRYM
Protein: Mitotic spindle organizing protein 2B (H7C173)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
Sequence:
XGREWSLAECACVVAASGAPRILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRNKGSAALGGALALAERSSREGSSQRMPRQPSATRLPKGGGPGKSPTRGST