wanglab/gogpt-training-data huggingface dataset:
Protein: Teichoic acid D-alanine hydrolase (EC 3.1.1.103) (Teichoic acid D-alanine esterase) (O50608)
Organism: Staphylococcus aureus
Function: Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA) (By similarity). Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MKFNKVKLVIHACVLLFIIISIALIFHRLQTKTHSIDPIHKETKLSDNEKYLVDRNKEKVAPSKLKEVYNSKDPKYKKIDKYLQSSLFNGSVAIYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYLPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVKAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHTAFYDEQPFKKYLAKGYAYNSTGLSFLRPNILDQYYGAGNLYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKQYPDEYRYGFYAKPTLNRLNGGFFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
Protein: Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m) (Q86SQ9)
Organism: Homo sapiens (Human)
Function: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14652022}; Peripheral membrane protein {ECO:0000269|PubMed:14652022}. Note=colocalizes with calnexin.
Interaction partners:
- Dehydrodolichyl diphosphate synthase complex subunit NUS1
- Geranylgeranyl pyrophosphate synthase
- Farnesyl pyrophosphate synthase
- All trans-polyprenyl-diphosphate synthase PDSS1
- All trans-polyprenyl-diphosphate synthase PDSS2
- Protein farnesyltransferase subunit beta
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Squalene synthase
- UbiA prenyltransferase domain-containing protein 1
Sequence:
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQKFSRLMEEKEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDISESLLDKCLYTNRSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLFEAILQFQMNHSVLQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRLHKLSARREERVQGFLQALELKRADWLARLGTASA
Protein: Type II secretion system protein C (T2SS protein C) (General secretion pathway protein C) (Pectic enzymes secretion protein OutC) (Q01564)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for the translocation of the multiple pectic enzymes.
Subcellular location: Cell inner membrane {ECO:0000305}.
Interaction partners:
- Secretin OutD
- Type II secretion system protein L
- Type II secretion system protein J
- Type II secretion system protein H
- Type II secretion system protein I
- Type II secretion system protein M
- Type II secretion system protein K
- Type II secretion system protein F
- Type II secretion system core protein G
- Type II secretion system protein E
Sequence:
MNISKLPPLSPSVIRRILFYLLMLLFCQQLAMIFWRIGLPDNAPVSSVQITPAQARQQPVTLNDFTLFGVSPEKNKAGALDASQMSNLPPSTLNLSLTGVMAGDDDSRSIAIISKDNEQFSRGVNEEVPGYNAKIVSIRPDRVVLQYQGRYEVLGLYSQEDSGSDGVPGAQVNEQLQQRASTTMSDYVSFSPIMNDNKLQGYRLNPGPKSDSFYRVGLQDNDMAVALNGLDLRDAEQAKKAMERMADVHNFTLTVERDGQRQDIYMEFGGDE
Protein: Protein ZINC INDUCED FACILITATOR 1 (Q8RWN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Major facilitator superfamily (MFS) transporter involved in zinc tolerance by participating in vacuolar sequestration of zinc.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17277087}; Multi-pass membrane protein {ECO:0000269|PubMed:17277087}.
Interaction partners:
- Metal transporter Nramp4
- Transcription factor bHLH47
- Ferric reduction oxidase 3, mitochondrial
- Probable nicotianamine synthase 4
- Metal tolerance protein 1
- Metal tolerance protein A2
- Oligopeptide transporter 3
- Transcription factor bHLH101
- Transcription factor ORG3
- Probable plastid-lipid-associated protein 14, chloroplastic
Sequence:
MAEEYKEALLEKQNYHDGCPGCKVEQMKQLRRGYPYLELSFVWIIVLSTSLPISSLYPFLYYMIEDFGVAKTEKDIGFYAGFVGCSFMLGRALTSVFWGIVADRYGRKPIILLGTISIAIFNALFGLSSNFWMAIGTRFLLGSFNCLLGTMKAYASEIFRDEYQATAMSAVSTAWGIGLIIGPALGGFLAQPADKYPNVFSQESLFGRFRYALPCFTISAFALLVTVLCCFIPETLHNHKLDSLSHDDSYDILEAASHESSPSTGKAGKNERKASQSLLKNWPLMSSIIVYCVLCLHDTAYSEIFALWANSPRKYGGLSYSTNEVGTVLAISGLGLFSFQVFVYPLAEKLLGPVLVTRYAGALMIPIQMSYPFIAGLSGLSLSLMLNCASILINVLSVSAITGLLILQNRAVDQSQRGAANGIAMTAMSLFKTVGPAGAGILFSWSERRLNAAFLPGSHMVFFVLNVIVVVGVALTFKPFLTTSRR
Protein: Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) (P00439)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.
Interaction partners:
- Pterin-4-alpha-carbinolamine dehydratase
- Dihydropteridine reductase
- Aromatic-L-amino-acid decarboxylase
- Pterin-4-alpha-carbinolamine dehydratase 2
- Sepiapterin reductase
- Tyrosine aminotransferase
- Aspartate aminotransferase, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
- Aspartate aminotransferase, cytoplasmic
- Tyrosinase
Sequence:
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK
Protein: Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18) (Q99542)
Organism: Homo sapiens (Human)
Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Nidogen-1
Sequence:
MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
Protein: Taste receptor type 2 member 4 (T2R4) (Q9NYW5)
Organism: Homo sapiens (Human)
Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.
Subcellular location: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 1 member 2
- Taste receptor type 1 member 3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Taste receptor type 2 member 3
- Taste receptor type 1 member 1
Sequence:
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
Protein: Short-chain dehydrogenase reductase 4 (AtSDR4) (EC 1.1.1.-) (F4J2Z7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein DELAY OF GERMINATION 1
- PAS domain-containing protein
- At3g48510
- Transcription factor bHLH57
- Emb|CAB62340.1
- NAD
- von willebrand factor A domain protein
- B3 domain-containing transcription factor ABI3
Sequence:
MPKLLVIFNIIYPLQSLKKDTFNFWWSFQKWKYNKTMSGLRQVLDGKIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSIGLDKASFYRCNVTDETDVENAVKFTVEKHGKLDVLFSNAGVLEAFGSVLDLDLEAFDRTMAVNVRGAAAFIKHAARSMVASGTRGSIVCTTSIAAEIGGPGPHSYTASKHALLGLIRSACAGLGQYGIRVNGVAPYGVATGMTSAYNEEAVKMLEEYGEALGNLKGVVLKARHIAEAALFLASDDSVYISGQNLVVDGGFSVVKLMTT
Protein: Probable ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Q10171)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).
Interaction partners:
- Ubiquitin-like protein 1
- Ubiquitin carboxyl-terminal hydrolase 14
- Probable ubiquitin carboxyl-terminal hydrolase 4
- Polyubiquitin
- Probable ubiquitin carboxyl-terminal hydrolase 9
- Ubiquitin thioesterase otu2
- Ubiquitin carboxyl-terminal hydrolase 15
- Probable ubiquitin carboxyl-terminal hydrolase 1
- Probable ubiquitin carboxyl-terminal hydrolase 16
- Putative ubiquitin thioesterase otu1
Sequence:
MWRPLENTPEVLEPYLQKIGVQDASVFDLFSLEEIPEYIPRPVHALLFVFPSSGTKTIYKGSRILPKDSDKVLWYPQTIPNACGTIGLLHAVSNGELRRKVNENDFIKSLIRTAEGSSIEERAKLIEDSKELEALHAAFAGPPLEVEGSEEDVETDLHFICFVKGKSKDDNHFYELDGRQEGPVQHSEIESDLLNAEVLSVIKNYIQSIDSPFFSLVAITTP
Protein: Energy-coupling factor transporter ATP-binding protein EcfA2 (ECF transporter A component EcfA2) (EC 3.6.3.-) (Q71WH8)
Organism: Listeria monocytogenes serotype 4b (strain F2365)
Function: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01710}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01710}.
Interaction partners:
Sequence:
MEIKLEQLGYCYQKNSPFEKRALLDVNVSFDSGSYSAIIGHTGSGKSTLLQHLNALLMPTEGKITVGDREIVAGVKQKKLRDLRKKVGIVFQFPEAQLFEETVEKDICFGPMNFGVSEEDAKLRAKKVIYEVGLTEEILSRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPTAGLDPHGREEIMEMFYNLHKEKGLTTVLVTHSMEDAARYAEKIVLMKAGTVLQIGTPREVFAKPDELVDLGLSVPDVVRFQGLFERKFDVKLTKTCLTIDELTTEMAPYLAKGGA
Protein: Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1) (Q8WVF1)
Organism: Homo sapiens (Human)
Function: May be involved in drug clearance in the placenta.
Subcellular location: Basal cell membrane. Note=Syncytiotrophoblast in placenta.
Interaction partners:
- WD repeat-containing protein 54
Sequence:
MSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKDEWTEVDRKRVLNDIISTMFNRKFMEELFKPQELYSKKALRTVYERLAHASIMKLNQASMDKLYDLMTMAFKYQVLLCPRPKDVLLVTFNHLDTIKGFIRDSPTILQQVDETLRQLTEIYGGLSAGEFQLIRQTLLIFFQDLHIRVSMFLKDKVQNNNGRFVLPVSGPVPWGTEVPGLIRMFNNKGEEVKRIEFKHGGNYVPAPKEGSFELYGDRVLKLGTNMYSVNQPVETHVSGSSKNLASWTQESIAPNPLAKEELNFLARLMGGMEIKKPSGPEPGFRLNLFTTDEEEEQAALTRPEELSYEVINIQATQDQQRSEELARIMGEFEITEQPRLSTSKGDDLLAMMDEL
Protein: Rho-related protein racI (Q9GPR2)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Ras guanine nucleotide exchange factor S
- GTPase activating protein homolog 1
- Putative rho GDP-dissociation inhibitor 1
- Mss4-like family protein
- Cofilin-1A
Sequence:
MQKSYIKLLVLGDSKTGKTTMMMTYSTGSFPTGYVPSHVDATSLDIEYNKQVCHVGFWDSSALAEFDNTRPSTYPNTNVIILCFSIDSPTSFENVSKKWIPEIRQYAPSIHTPIILLGTKCDLREDENTINLLKENNQMPPISYKQGLALSKEIKATMYLECSSLCNQGVNEIFKQVVRCHLYCKDGVLNDPTTTTSNTSKCIIQ
Protein: Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1) (Q9BU20)
Organism: Homo sapiens (Human)
Function: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29038301}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:29038301}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29038301). Recruitment to the centriole depends on TTBK2, INTU, and its own GTPase activity (By similarity). {ECO:0000250|UniProtKB:A2A825, ECO:0000269|PubMed:29038301}.
Interaction partners:
- Protein inturned
- Protein fuzzy homolog
- WD repeat-containing and planar cell polarity effector protein fritz homolog
Sequence:
MARPPVPGSVVVPNWHESAEGKEYLACILRKNRRRVFGLLERPVLLPPVSIDTASYKIFVSGKSGVGKTALVAKLAGLEVPVVHHETTGIQTTVVFWPAKLQASSRVVMFRFEFWDCGESALKKFDHMLLACMENTDAFLFLFSFTDRASFEDLPGQLARIAGEAPGVVRMVIGSKFDQYMHTDVPERDLTAFRQAWELPLLRVKSVPGRRLADGRTLDGRAGLADVAHILNGLAEQLWHQDQVAAGLLPNPPESAPE
Protein: Co-chaperonin GroES (10 kDa chaperonin) (Chaperonin-10) (Cpn10) (Q97NV3)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00580}.
Interaction partners:
Sequence:
MLKPLGDRVVLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQGVRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE
Protein: Actin-related protein 7 (Q8L4Y5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis and all plant development stages, probably through a chromatin-mediated regulation of gene expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:12609034, ECO:0000269|PubMed:15063870, ECO:0000269|PubMed:16040647}. Cytoplasm {ECO:0000269|PubMed:12609034}. Note=Localized in the nucleus during the interphase, but is released into the cytoplasm during the mitotic phase (PubMed:12609034).
Interaction partners:
- Chromatin structure-remodeling complex protein BSH
- Actin-related protein 9
- SWI/SNF complex subunit SWI3D
- SWI/SNF complex subunit SWI3A
- Actin-related protein 5
- RuvB-like protein 1
- High mobility group B protein 10
- SWI/SNF complex subunit SWI3C
- Actin-related protein 4
- SWI/SNF complex subunit SWI3B
Sequence:
MEALVVDAGSKFLKAGAAIPDQSPAMIIPSQMKRMVDDGSSSADNPTTVFEDVTLDPIERGLIRDWDAMEDLLRYVVYTGLGWEEGNEGNILFTDPLCTPKAIREQLVQLMFETFNVSGFYASEQAVLSLYAVGRISGCTVDIGHGKIDIAPVLEGAVQHIASKRFELGGTELTKLFAQELGKTNPSMNLSMSDVEKLKEQYANCAEDEIAYKKTQNCEIEQHTLPDGQVISIGRERYSVGEALFQPSILGLEEHGIVEQLVRIISTVSSENHRQLLENTVLCGGTTSMTGFESRFQKEANLCSSAIRPTLVKPPEYMPENLGMYSAWVGGAILAKVVFPQNQHVTKADYDETGPSVVHRKCF
Protein: E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C) (Q9ULV8)
Organism: Homo sapiens (Human)
Function: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Interaction partners:
- Epidermal growth factor receptor
- Proto-oncogene tyrosine-protein kinase Src
- Tyrosine-protein kinase Fyn
- Tyrosine-protein kinase Yes
- E3 ubiquitin-protein ligase CBL-B
- E3 ubiquitin-protein ligase CBL
- SH3 domain-containing kinase-binding protein 1
- Endophilin-A3
- Endophilin-B2
- Endophilin-A1
Sequence:
MALAVAPWGRQWEEARALGRAVRMLQRLEEQCVDPRLSVSPPSLRDLLPRTAQLLREVAHSRRAAGGGGPGGPGGSGDFLLIYLANLEAKSRQVAALLPPRGRRSANDELFRAGSRLRRQLAKLAIIFSHMHAELHALFPGGKYCGHMYQLTKAPAHTFWRESCGARCVLPWAEFESLLGTCHPVEPGCTALALRTTIDLTCSGHVSIFEFDVFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQERLQACRDKPGSYIFRPSCTRLGQWAIGYVSSDGSILQTIPANKPLSQVLLEGQKDGFYLYPDGKTHNPDLTELGQAEPQQRIHVSEEQLQLYWAMDSTFELCKICAESNKDVKIEPCGHLLCSCCLAAWQHSDSQTCPFCRCEIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPRKPRNAQPKVRLLKGNSPPAALGPQDPAPA
Protein: Holliday junction branch migration complex subunit RuvB (EC 3.6.4.-) (Q9A3G8)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00016}.
Interaction partners:
- Holliday junction branch migration complex subunit RuvA
- Crossover junction endodeoxyribonuclease RuvC
- S-adenosylmethionine:tRNA ribosyltransferase-isomerase
- Uncharacterized protein
- FtsW/RodA/SpoVE family cell cycle protein
- Protein RecA
- UvrABC system protein A
- ATP-dependent Clp protease, ATP-binding subunit ClpA
Sequence:
MTRVISGEPQHGDLAPADRALRPQTLAEFVGQEQAKGNLRVFIEAAKGRGEALDHVLLFGPPGLGKTTLAQIVARELGVNFRATSGPVLNKPGDLAAILTNLEANDVLFIDEIHRLSSNVEEILYPAMEDHVLDLVIGEGPSARSIRIDLAPFTLVAATTRAGMLATPLRDRFGIPIRLEFYTPAELRHVLQHAARKMGAPLTDDGADEIAKRARGTPRVAGRLLRRVRDFATADGADRIDRKAAAMALARLEVDESGLDSLDRRYLRAMIENYGGGPVGVETIAYAIAEARDAVEDVIEPYLMQQGFIQRTPRGRMACGKAYLHLGLTPPAAPPGQAQGALFDEG
Protein: Uncharacterized protein (Q580M5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQLLHAQQEGMKNIRQSEASHSDENDKKERGTRSGSTTGTCSEFDVCAVYDDDDVPLAAQFVRSCPPLTDPSWAMEELLRINSHVAVWTGSALPNSVWALPGSGHCPFGSTDADFARIR
Protein: N-arachidonyl glycine receptor (G-protein coupled receptor 18) (E3TFF8)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}.
Interaction partners:
- Cannabinoid receptor
Sequence:
MEQNTSLTINPEGYLPPAFKIVSLVFYSIIFSVGLVVNLTALWVFALTTKRRSSVTIYMINVAVVDLIFILLLPFRMAYYSGDYWPFGDMFCRINAALTVLYPCLALWLFALISADRYVAIVQPRHSKELKNVHKALLSCVGIWVMTLGGAASLLFLEEDPDLFSNHTTCLKMHDIVYLRRDNSVHFARLAFFFLVPMLIMVGCYISIVDNLIHGRTSKLKPNVKQKSIRIIITLIMQVLVCFVPFHVCFVLLLFENIGQDYSTWGAFTTFLMNMSTVLDIILYYIVSKQFQDRVISVILYRNYLRSVRRKSRHTGSVRSLSNLTSAMI
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q76NN7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- ADP/ATP translocase
- Raf kinase inhibitor
- non-specific serine/threonine protein kinase
- Cysteine proteinase falcipain 1
- Uncharacterized protein
- Kelch domain-containing protein, putative
- Citrate synthase
- Citrate/oxoglutarate carrier protein, putative
- DNA polymerase II subunit 2
- Ribosome-interacting GTPase 1, putative
Sequence:
MSKRSKVFFDISIDNSNAGRIIFELFSDITPRTCENFRALCTGEKIGSRGKNLHYKNSIFHRIIPQFMCQGGDITNGNGSGGESIYGRSFTDENFNMKHDQPGLLSMANAGPNTNSSQFFITLVPCPWLDGKHVVFGKVIEGMNVVREMEKEGAKSGYVKRSVVITDCGEL
Protein: Choline transporter (P19807)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Sole choline transporter in yeast.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Myo-inositol transporter 1
- Glycerol-3-phosphate O-acyltransferase 1
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Ethanolamine kinase
- Cholinephosphotransferase 1
- Phosphatidylethanolamine N-methyltransferase
- Phosphatidyl-N-methylethanolamine N-methyltransferase
Sequence:
MSIRNDNASGGYMQPDQSSNASMHKRDLRVEEEIKPLDDMDSKGAVAADGEVHLRKSFSLWSILGVGFGLTNSWFGISTSMVAGISSGGPMMIVYGIIIVALISICIGTSLGELSSAYPHAGGQFWWSLKLAPPKYKRFAAYMCGSFAYAGSVFTSASTTLSVATEVVGMYALTHPEFIPKRWHIFVCFELLHLFLMFFNCYGKSLPIISSSSLYISLLSFFTITITVLACSHGKFNDAKFVFATFNNETGWKNGGIAFIVGLINPAWSFSCLDCATHMAFEVEKPERVIPIAIMGTVAIGFVTSFCYVIAMFFSIQDLDAVLSSTTGAPILDIYNQALGNKSGAIFLGCLILFTSFGCVIACHTWQARLCWSFARDNGLPLSRLWSQVNPHTGVPLNAHLMSCAWITLIGLLYLASSTAFQSLITGCIAFLLLSYIIPVICLLAKKRNIAHGPFWLGKFGFFSNIVLLGWTVFSVVFFSFPPVLPVTKDNMNYVCVVIVGYTAYSILYWKYKGKKEFHALEESENEQAEYSNNFDTIEDSREFSVAASDVELENEHVPWGKK
Protein: Uncharacterized protein YEL068C (P39977)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Sporulation protein RMD6
- Phosphoribosylglycinamide formyltransferase
- Hexose transporter HXT13
Sequence:
MKILALAVAFQGLALVCCTDTTDNYNNFTHNTSTFYRIADYDKRFWSVKLPPVNWTTCGNEDHPWITIHYDEIDKLVDDKLASWDKGPVPDREEFRNSILRQARCDRPHY
Protein: Piercer of microtubule wall 2 protein (A0A3Q1LFK7)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}.
Interaction partners:
- Cilia- and flagella-associated protein 161
- EF-hand domain-containing family member C2
- Methyl-CpG-binding domain protein 1
- Outer dynein arm-docking complex subunit 1
- Tektin-3
- Tektin-1
Sequence:
MTECDWEKKSTSASNSDTEMKPELPPCVNPGNPVFSCMLDPKTLHTTTSLSKPKMIMYKTNSSNYGEFLPMPQFFPCYYTPREQVFSSHIRATGFYQNNTLNTAPDRTRTLDFPNFQHTL