Protein: Acetyl-CoA carboxylase 2 (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)] (F4I1L3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Acetyl-CoA acetyltransferase 1
- Acetyl-CoA acetyltransferase 2
- EMBRYO DEFECTIVE 3147
- Biotin carboxylase, chloroplastic
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic
- Beta-ketoacyl-[acyl-carrier-protein] synthase III, chloroplastic
- Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic
Sequence:
MEMRALGSSCSTGNGGSAPITLTNISPWITTVFPSTVKLRSSLRTFKGVSSRVRTFKGVSSTRVLSRTKQQFPLFCFLNPDPISFLENDVSEAERTVVLPDGSVNGAGSVNGYHSDVVPGRNVAEVNEFCKALGGKRPIHSILVATNGMAAVKFIRSVRTWAYETFGSEKAVKLVAMATPEDMRINAEHIRIADQFVEVPGGTNNNNYANVQLIVEMAEVTRVDAVWPGWGHASENPELPDALKEKGIIFLGPPADSMIALGDKIGSSLIAQAADVPTLPWSGSHVKIPPGRSLVTVPEEIYKKACVYTTEEAIASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFIMKVASQSRHLEAQLLCDQYGNVAALHSRDCSVQRRHQKIIEEGPITVAPQETIKKLEQAARRLAKSVNYVGAATVEYLYSMDTGEYYFLELNPRLQVEHPVTEWIAEVNLPAAQVAVGMGIPLWQIPEIRRFYGMEHGGGYDSWRKTSVVASPFDFDEAESLRPKGHCVAVRVTSEDPDDGFKPTSGEIQELSFKSKPNMWSYFSVKSGGGIHEFSDSQFGHVFAFGESRSVAIANMVLALKEIQIRGDIRTNVDYTIDLLHASDYRENKIHTGWLDSRIAMRVRAERPPWYLSVVGGALYKASTTSSAVVSDYVGYLEKGQIPPKHISLVHSQVSLNIEGSKYTIDVVRGGSGTYRLRMSNSEVVAEIHTLRDGGLLMQLDGKSHVIYAKEEATGTRLLIDGRTCLLQNDHDPSKLMAETPCKLLRYLVSDNSSIDTDTPYAEVEVMKMCMPLISPASGVIHFKLSEGQAMQAGELIAKLDLDDPSAVRKAKPFRGSFPRLGLPTAISGKVHQRCAATLNAARMILAGYDHKVDEVLQDLLNCLDSPELPFLQWQECFAVLATRLPKDLRNMLELKYKEFEIISKTSLTPDFPAKLLKGILEAHLSSCDEKERGSLERLIEPLMSLVKSYEGGRESHARLIVHSLFEEYLSVEELFNDNMLADVIERMRQQYKKDRLKIVDIVLSHQGIIHKNKLVLRLMEQLVYPNPAAYREKLIRFSALNHTNYSQLALKASQLLEQTKRSELRSNIARSLSELEMFTEAGENMDTPKRKSAISETMENLVSSSLAVEDALVGLFDHSDHTLQRRVVETYIHRLYQPYVVKESVRMQWHQSGVIASWEFLEHFERKNTGPDDHEISEKGIVAKSSKRKRGTMVIIKSLQFLPSIINASLRETNHSHCEYARAPLSGNMMHIAVVGINNQMSLLQDSGDEDQTQERVNKLAKILKEEEVSLTLCSAGVGVISCIIQRDEGRTPMRHSFHWLMEKQYYVEEPLLRHVEPPLSVYLELDKLKGYSNIQYSPSRDRQWHMYSVTDRPVPIKRMFLRSLVRQTTMNDGFLLQQGQDYQLSQTVLSMAFTSKCILRSLMNAMEELELNAHNAAMKPDHAHMFLCILREQQIDDLVPYPRRFEVNAEDEETTVETILEEATQEIHRSVGVRMHALGVCEWEVRLWLVSSGLANGAWRVVVANVTGRTCTVHIYREVEATGRNSLIYHSITKKGPLHGTLINGQYKPLNNLDRKRLAARRSNTTYCYDFPLAFETALELNWASQHSGVRKPCKNRLINVKELVFSNTEGSLGTSLIPVERPAGLNDIGMVAWILEMSTPEFPMGRKLLIVANDVTFKAGSFGPREDAFFLAVTELACTKKLPLIYLAANSGARLGVAEEVKACFKVGWSDEVSPGNDFQYIYLSSEDYARIGSSVIAHEVKLPSGETRWVIDTIVGKEDGLGVENLTGSGAIAGAYSRAYNETFTLTFVSGRSVGIGAYLARLGMRCIQRLDQPIILTGFSTLNKLLGREVYSSHMQLGGPKIMGTNGVVHLTVSDDLEGVSAILNWLSYIPAYVGGPLPVLAPLDPPERTVEYIPENSCDPRAAIAGINDNTGKWLGGIFDKNSFVETLEGWARTVVTGRAKLGGIPIGVVAVETQTVMHVIPADPGQLDSHERVVPQAGQVWFPDSAAKTAQALMDFNREQLPLFIIANWRGFSGGQRDLFEGILQAGSAIVENLRTYRQPVFVYIPMMGELRGGAWVVVDSQINSDYIEMYADETARGNVLEPEGMIEIKFRRKELLECMGRLDQTLINLKANIQDAKRNKAYANIELLQKQIKTREKQLLPVYTQIATKFAELHDTSMRMAAKGVIKSVVEWSGSRSFFYKKLYRRIAESSLVRNIRKASGDILSYKSAMGLIQDWFRKSEIAKGKEEAWTDDQLFFTWKDNVSNYEQKLSELRTQKLLNQLAEIGNSSDLQALPQGLANLLNKVDLSRREELVDAIRKVLG