wanglab/gogpt-training-data huggingface dataset:
Protein: HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27) (Q9CQS9)
Organism: Mus musculus (Mouse)
Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NVX0}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9NVX0}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000250|UniProtKB:Q9NVX0}.
Interaction partners:
- HAUS augmin-like complex subunit 7
- HAUS augmin-like complex, subunit 6
- HAUS augmin-like complex subunit 8
- HAUS augmin-like complex subunit 1
- HAUS augmin-like complex subunit 3
- HAUS augmin-like complex subunit 4
- HAUS augmin-like complex subunit 5
Sequence:
MAAANPWDPASSQTAAGLLLNHLVASGIVTKEMLDVSKKMAPCFVNFSRLQQISDIQAEIYQNNLELELLKLEKDTADLIHPSHLIEKCDVLQSMNNHLEAVLKEKHAIRQRLLRPMCQENLPLEAVYHRYVVHMLDLAVTFIEKFETHLETVKNSPHLDANLKQMSKALAKMDILVNKTEELAENILKWRELQTEISLYIPKMLTEERHLHELDIVPPLPFFPKAHTETSRAK
Protein: Tolloid-like protein 1 (EC 3.4.24.-) (Metalloprotease xolloid-like) (Xenopus tolloid-like protein 1) (Xlr) (Q8JI28)
Organism: Xenopus laevis (African clawed frog)
Function: Protease which processes procollagen C-propeptides, such as chordin. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MNMPSWLIFLLTGWTFCGNFFACGGLDYDYPNYENEEEKNEAIDYKDPCKAVVFWGDIALDEEDLKMFHIDRTIDLTQHSNEKLGHTTGGLEEHDLSKKRGALYQLIERIRRFGSGQENTTANSQKVDNNQSGKSKKIRIPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPGEVHSLGESYDFDSIMHYARNTFSRGMFLDTILPSRDENGLRPPIGQRTRLSKGDIAQARKLYRCPACGETLQESTGNFSSPGFPNGYPSYTHCIWRISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWKKSPLLGRFCGDKLPDVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIHKDAGQIQSPNYPDDYRPLKECVWKITVAENYNVGLTFQAFEIERHDNCAYDYLEVRDGSSENSPLIGHFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFLKEEDECARPDNGGCEQRCVNTLGSYKCSCDPGYELAPDKKSCEAACGGLLTKLNGTITTPAWPKEYPPNKNCVWQVVAPSQYRISMKFDYFELEGNEVCKYDYVEVRSGLSSDSKLHGKFCGTEVPEVITSQFNNMRIEFKSDNTVSKKGFRAHFFSDKDECSKDNGGCQHECINTIGSYVCQCRNGFVLHDNKHDCKEAECEHRIHSSNGVITSPNWPDKYPSRKECTWEISATPGHRVKLSFSEFEIEQHQECAYDHLEVFDGETEKSSILGRLCGSKVPEPLVATGNEMFIRFVSDASVQRKGFQATHSTECGGRLKAEAKPRDLFSHAQFGDNNYPVQADCEWILMTERGLRIELNFQTFEVEEEADCGYDFMELFDGHDASAMRLGRFCGSGPPEEIVSTGDAVLIHFHTDDTISKKGFHIRYRSVKYQDILHTK
Protein: DNA repair protein RAD51 homolog 1 (RAD51 homolog A) (Q08297)
Organism: Mus musculus (Mouse)
Function: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12531026}. Cytoplasm {ECO:0000269|PubMed:12531026}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q06609}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q06609}. Chromosome {ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:30949703, ECO:0000269|PubMed:32463460}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q06609}. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner. Recruited at sites of DNA damage following interaction with TOPBP1 in S-phase. Colocalizes with ERCC5/XPG to nuclear foci in S phase. Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner. {ECO:0000250|UniProtKB:Q06609}.
Interaction partners:
- Breast cancer type 2 susceptibility protein homolog
- DNA repair protein RAD52 homolog
- Breast cancer type 1 susceptibility protein homolog
- DNA repair and recombination protein RAD54-like
- Partner and localizer of BRCA2
- Exonuclease 1
- RAD51-associated protein 1
- Serine/threonine-protein kinase Chk1
- Meiotic recombination protein DMC1/LIM15 homolog
- Serine-protein kinase ATM
Sequence:
MAMQMQLEASADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGYHTVEAVAYAPKKELINIKGISEAKADKILTEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Protein: Penicillopepsin-2 (EC 3.4.23.20) (Aspartic protease pepA) (Penicillopepsin-JT2) (P78735)
Organism: Penicillium janthinellum (Penicillium vitale)
Function: Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q01972}.
Interaction partners:
Sequence:
MVVFSKITVVLAGLATVASAVPTGTSRKSTFTVNQKARPVAQAKAINLPGMYASALSKYGAAVPASVKAAAESGTAVTTPEANDVEYLTPVNVGGTTLNLDFDTGSADLWVFSSELSSSESTGHSLYKPSSNATKLAGYSWSITYGDQSSASGDVYKDFVVVGGVKASPQAVEAASQISQQFVNDKNNDGLLGLAFSSINTVKPKSQTTFFDTVKGQLDSPLFAVTLKHNAPGTYDFGFVDKNKYTGSLTYAQVDSSQGFWSFTADGYKIGSKSGGSIQGIADTGTTLLLLPDNVVSDYYGQVSGAQQDSSAGGYTVPCSAQLPDFTVTIGSYNAVVPGSLINYAPLQSGSSTCFGGIQSNSGLGFSIFGDIFLKSQYVVFDANGPRLGFAPQA
Protein: SH2 domain-containing protein (Q54XJ7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MTTSIVNENNKSKKGIGGGIELTISPNKMGTNTDINELLLSLPDLHKRFEENPDDSENFIKYVILLIFLKKKATSPDSSSSSSSSSSSSSPSTPTPTSSPSTRRSSKSSTTTTTSTTNNNNNNNKVSINEVFIYIDKLKKSPLIASDLFEISCSNPVLVPMGPINRVDHYNPVSIPKFNQAVYYNFNGGGDGKVNSQQQQQSLYGNVDKASTTTTTTTTTTTTTTTNTTTSTSKSSISINKNINIIGNSRDRSSSAPVSISKDKNILEIEGLKSSQNTLLPNLSNFQIGNSPPLPSFIHNNSNNPNNSLQNKNSSSRGINNNRSSLNMGSAPSPLYVEDDYNPNEDDSDSDNDNYNDNNESTTTTTTTTTTTTNLKEKAINSLGNMSDSSGDLHFEKLSIGDLEALKTKINNSNGLGSLFKKEEIEKPTEPIRNWSLDFWNALQMDHNCGNENLKRSQKIQAIAEEFVNVATKHGVTIIQEKGLSSGWTIPSYDAGGVAGGLKYLKSGIFFKFAVDCYGIYGGDAFAMKSAGHELKGLMGYFNCQIDGLFLPLMTLIDYMGYRLIATSQLNIDGDKTLVYGSNDGGETVYNKSEEMEDKMRKAGEILNLKGHYTGQSDNKTFLYGPCDIEGHITKDNHFVVIDTARVFPPEKPIPGKTGSHLYTLLRPELVRSSKMPLSSDAFTKFAGPDRDKNNEEVERSQKRLLNHIIPSFVLLMNQKVKKTKCKNIMELSQNLMLIDSMHREGINVRYLQRLKKTDFHAIDQRLSTIINTEIIARKIKNRLRSFLRSLPLINNNNNNNSIDNNNNNNNNNNNNNNNNNDDNNPNNNNNINYNINLPDICKFLNRMMCISLLQSCDLDGFSLELLLYRISQMMGIVFRDGLYKKLGDQSESIQPDDIISITPKVKFLHSIPYQQGVSLFHQAISLSKQQQQQQQPQPQPQQPTNTSTTTSTSNNTSNNINNNNNNPDGSNDGSDDNINNNNNNNNNNNNNNNNNNNLTNSADNLFIQAAEKFKVAIQSKPDDYEILTHWGILLSMRARLISNKTYIKAHGKAEIEKLYQSAIEKFQLAVKLKRNHHYALFNWAEALRGWAAIRPGTDIAHELEKKAKMKLKEAGVFEKRWFFQTLETQGVASLLSGAPAGGFIIRNSNSRPGSFVFSYLSDPHRKILHSIIKSSSHGYHVENLPPRRVSSSSSSSSSSSSNSSNNIPKSGSSQNLNELLASSLNSSGSSGGSNISPTNSSTTSPTISRSSSVNNLNQELKFNEASTTVPTRNSTSLSGQSPTTTVSYKTLEEFVSDKIKQGYIPITKDWWE
Protein: Collagen, type XXII, alpha 1 (E9Q7P1)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Collagen alpha-1
- WD repeat-containing protein 90
Sequence:
MPVFTSRRAMAVPRGNPLACLLWILLLWGGDGGCQAQRAGCKSVQYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPGHTRVGVVRYSDRPTTAFELGHFNSREEVKAAARRITYHGGNTNTGDALRYITSRSFSAQAGGRPGNRAFKQVAILLTDGRSQDLVLDAAAAAHAAGIRIFAVGVGAALKEELDEIASEPKSAHVFHVSDFNAIDKIRGKLRRRLCENVLCPSVRVEGDRFKHTNGGTKEITGFDLMDLFSVKEILGKRENGAQSSYVRMGSFPVVQRTEDVFPQGLPDEYAFVTTFRFRKTSRKEDWYIWQVIDQYGIPQVSIRLDGENKAVEYNAVGAMKDAVRVVFRGPRVDDLFDRDWHKMALSIQAQNVSLYIDCLLVQTLPIEERENIDIQGKTVIGKRLYDSVPIDFDLQRIVIYCDSRHAELETCCDIPLGPCQVTVVTEPPPAPPQLPTPGSEQIGFLKTINCSCPPGEKGERGFAGPLGLPGQKGDAGPIGLMGAPGPKGEKGDSGRGPFIHGEKGEKGSLGPPGPPGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPAGPVGAPGLRGERGERGPPGEKGERGLDGFPGKPGETGEQGRPGPPGVAGLQGEKGDVGPAGPPGVPGSVVQREGLKGEQGAPGPRGHQGLPGPPGAPGLIGPEGRDGPPGPPGLRGKKGEMGPPGTPGALGPQGPPGPPGVPGPPGPGGPPGLPGELGFPGKPGPAGHAGTPGKDGLNGPPGLPGSKGEPGDSGESGVPGMPGPRGEVGERGLAGHPGEKGEVGLPGAPGFPGVHGEKGDQGEKGELGLPGLKGARGEKGEVGPAGPPGLPGSPSVFTPHPRMPGEQGPKGEKGDPGEPGALGPQGHPGELGPRGPIGPPGAKGHDGAQGPPGAAGNPGAPGPAGPPGLSGPPGSLGSPGVRGAPGKDGERGEKGTAGEEGSPGPAGPRGDPGAPGLPGPPGKGKDGEPGLRGPPGLPGPLGIKGDRGTPGIPGSPGSRGDPGIGVAGPPGPSGRPGDKGPPGSRGLPGFPGPQGPAGQDGAPGNPGERGPPGKPGPSSLLSPEDINLLVKDVCNDCPPGPPGLPGLPGFKGDKGLPGKQGREGTEGKKGDTGPPGPPGPPGVAGPQGSQGERGAEGEVGQKGEQGHPGVPGFMGPPGNPGPPGADGNAGVAGPPGPQGPQGKEGPPGPQGPSGIPGVPGEEGKQGRDGKPGPPGEPGKTGEPGLSGAEGARGPPGFKGHTGDPGPPGLRGEPGIAGPSGRDGSPGKDGDTGPAGPQGPRGTRGPPGSSGSPGSPGDPGRPGALGQKGNKGESGSPGLPGFQGPRGPPGEAGEVGAPGKEGAPGKPGEPGSKGERGDPGIKGDKGPPGGKGQPGDPGTPGHKGHTGLMGPQGQPGESGPPGPPGPPGQPGFPGLRGESPSMDTLRRLIQEELGKQLEAKLAYLLAQMPPAHMKSSQGRPGPPGPPGKDGLPGRTGPMGEPGRPGQGGLEGPSGPMGPKGERGAKGDPGTPGVGLRGEMGPPGIPGQPGEPGYAKDGLPGSPGPQGETGLAGHPGPPGPPGPPGLCDPSQCAYFASLAARPSNVKGP
Protein: Chloroplast RNA-binding protein 29 (F4JAF3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
MSASASSLSAFNPKSLPLCVSRPASVSVLPPSLSFKLHSDHLVSIFASSALKCSSPAEYPSRFVRNVAVSSDFEVEEDDMFADGDDSAPVERNSFSPDLKLFVGNLSFNVDSAQLAQLFESAGNVEMVEVIYDKVTGRSRGFGFVTMSTAAEVEAAAQQFNGYVSRYLCSLLCLYLLIRVLCGLEFEGRPLRVNAGPPPPKREESFSRGPRSGGYGSERGGGYGSERGGGYGSERGGGYGSERGGGYGSQRSGGGYGGSQRSSYGSGSGSGSGSGSGNRLYVGNLSWGVDDMALENLFNEQGKVVEARVIYDRDSGRSKGFGFVTLSSSQEVQKAINSLNGADLDGRQIRVSEAEARPPRGQF
Protein: Uncharacterized protein (Q386T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTTWLFNVSVLHLSASFSEPRLASFAAEGQLACRMFFNGKPLDLTFQPASEMIGGGKPQSTFLYRIQSLTVADLLNMLRQRSVRFYIVPVKRNSDPLGKEIRAACRATTNIMCIAERGGGLLELPLTSAASKEEGNSGIVGTLSVCIAFDQLAEVELRLKEFYVSGLENGIYGLHCRLAPFKEGVVSKLTRALSGTARWTDAEVPMAKYRGVLRNLKKHQFAIAVYLIDGNNNERPVASFEVDLAIKNTSASCKEITIPFSMSDGKTSTTVNGALQLSGLPTFEDEMQKILRAGPACVDTEDEKKEKNKFSDPEGAKSSEAESTTEIDTENSSMGRHLPEYSQGSSPPIVSRTSTPTRASPRDISSPPSEDQDAEDCRFSFPSKNSISALWHSEADLESPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPPPEKDMDVHGDVPPPTPSPEKDMDVHGDVPPPTPPPEKDMDVHGDVPMVVEGSANVDSSCVLVCSGGAEEVVDVPADLESVDDENVYVSELQSTAVLNEDVTLLLDECDRMVVGRDEGASGRSVGVPTLQASNLIEFPPPSNGKEPATSREEAADLLLTRERELLDAMEHENECIDMLVQSLRRMDNASEKDRAAYCAEVDRLQQQFKLLDEAEEELTLLLARATQRFNLCREERRKSQLELLEARARKETYSLALAMMDRELRTQFDNDGNRRPGGMFLSKSDSS
Protein: Histone acetyltransferase TAP1 (GmTAP1) (EC 2.3.1.48) (K7MTW9)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Acetylates histones H2A and H3 in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30346270}. Nucleus {ECO:0000269|PubMed:30346270}. Note=Localizes to the cytoplasm, but is relocated to the nucleus when interacting with the effector Avh52 from the pathogen Phytophtora sojae. {ECO:0000269|PubMed:30346270}.
Interaction partners:
- V-type proton ATPase subunit
- V-type proton ATPase subunit F
- V-ATPase proteolipid subunit C-like domain-containing protein
- Uncharacterized protein
- V-type proton ATPase subunit D
- Tyrosine decarboxylase
- Vacuolar proton pump subunit B
- Vacuolar proton pump subunit B
- Vacuolar proton pump subunit B
- Vacuolar proton pump subunit B
Sequence:
MSMLSLLRSQLFNFMPIIHCLLKLNSTRKFKSFQLKAGFWESIKSGLMKNNSMQVIDPPSTDEENVEPLSQDFVLVEKTEPDGTIEQIIFSSGGDVDVYDLQALCDKVGWPRRPLSKLAAALKNSYIVASLHSIRKSHGSEGNEQKRLIGMARATSDHAFNATIWDVLVDPGYQGQGLGKALIEKLIRTLLQRDIGNITLFADSQVVEFYRNLGFEADPEGIKGMFWYPNH
Protein: ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) (P41162)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX20
Sequence:
MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDTHSPTNDVQPGRFSASSLTASGQESSNGTDRKTELSELEDGSAADWRRGVDPVSSRNAIGGGGIGHQKRKPDIMLPLFARPGMYPDPHSPFAVSPIPGRGGVLNVPISPALSLTPTIFSYSPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEESTQFSIKLQPPPVGRKNRERVESSEESAPVTTPTMASIPPRIKVEPASEKDPESLRQSAREKEEHTQEEGTVPSRTIEEEKGTIFARPAAPPIWPSVPISTPSGEPLEVTEDSEDRPGKEPSAPEKKEDALMPPKLRLKRRWNDDPEARELSKSGKFLWNGSGPQGLATAAADA
Protein: Kinesin family member 1B (Kinesin-like protein KIF1B isoform X21) (Kinesin-like protein KIF1B isoform X26) (F1QJ64)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSGASVKVAVRVRPFNSRETGKESKCIIQMQGNSTTILNPKNPKEPKTFSFDYSYWSHTSPDDPSFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEEGQEGIIPQLCEELFEKINDNNNEEISYSVEVAYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINFDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEVSRLKELLRAQGLGDILDIEPMGDDCLGSGSKSPMGCLTASPSSGSLCSQAGLQSVSSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGSETYVNGKRVNSAVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPVEPVDWTFAQRELLEKQGIDMKQEMEKRLTEMEILYKKEKEEADQLLEQQRLDGDSDSGDDSDKRSCEESWRLITSLREKLPPSKLQTIVKKCGLPSSGKRREPVKMYQIPQRRRLTKDSKWVTISDLKIQAVKEICYEVALNDFRHSRQEIEALAIVKLKELCATYNKKDPNERDSWRAVARDVWDTVGVGDERIEDVITNGRGVADMDDLKVHIDKLEDILHEVKKQNNTKDEEIRALRTKMLKMEQVIPLISNENLSQEKTSRGGPMRARSSSEGKALEEKPSDEQSDDQMCKMVDDDSSFRRGRMRWMRQEQVRLKNLQQQEISKQLRRQTGPHRFIPPEDRKLRFPFKSNPKHRNSWTPGTHIIITDEQVIELKVPKEAVQEENDDTEESVEPRPQVVPTIQTYPPLPSPMGQRKSKDLEQGVSHRPNQSQKLHERGRSNSFNSSQRASDSTETFNSGNRKPPHPQQAFYQPRYNQNQHYYPPQPHPQFFHYNTDAGYQQYPPNQQHSHHNNFNTPPRMRRQLSAPNLKGSRETAV
Protein: Cytokine-inducible SH2-containing protein (B9EPA9)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- Elongin-C
- Cullin-5
- Cullin-5
- Cullin-5
- Suppressor of cytokine signaling 5
- Elongin-B
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- RING-box protein 2
- RING-box protein 2
Sequence:
MILCVQGPRPLLSGSPTEGPVGMRTGSISSPHCLHSTPPQWDPTNDLRTIAKNFFYLDTSGWYWGAITAGQAHAALQAASEGAFLIRDSSHPLYMLTLSVRTARGPTSIRIQYSGARFLLDSSSPARPSLLSFPDVPSMVQYYVGPTRKVQKGKVEETHGAQPAQRTVQESTVVLKLKRALHKPQAFPSLQHLTRLTINRSTGCPDQLPLPRPLVRYLQDYPFHV
Protein: Hybrid proline-rich protein (G0X3E2)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MASYKLCALFLLFTLLFHSTFTTACNSCKPKPPPCPPPSCPKDTLKLGVCADVLGLVNVIVGTPPSSKCCALLQGLADLEAALCLCTAIKANVLGINLNIPVSLSLILSACQKEVPPGFKCE
Protein: Putative cystathionine gamma-synthase YML082W (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) (Q04533)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).
Interaction partners:
- Cystathionine beta-lyase
- Cystathionine beta-synthase
- Cystathionine gamma-lyase
- Putative mitochondrial cysteine synthase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Putative cystathionine beta-lyase
- Homocysteine S-methyltransferase 1
- Homocysteine S-methyltransferase 2
- Sulfite reductase subunit beta
- Branched-chain-amino-acid aminotransferase, mitochondrial
Sequence:
MVSAQVATELGQPIPLDTQHAVSVCFPTWKSVISYVEKDPKVLGCLKSGYPRFWIHPSIQKLRDILIEKYAKENETCFCFPSYRVAKRCREYVRRKCAHRNGKVRILQLATAKPINEEQKTWKRECKIAVVFVDGAYENILKQYWQYTGEIISSRLAEYVLHELFMVEKKSSPAEEKEYIEMRYGRNLNFAFADRAKELIKKRIATKVIDKDEHDEEENYHFLAGNQDEQDFQDTFLDSSLNEANHGEDHDGGISGEVDSQEEPHNGLVSTIPPEPIEMSTIEEEQSVEEDAGRCALRVCPERDVFLFPSGMASIFTAHRLLLQWDSLRLNRSRNGSDVTSSPPNKKTVIFGFPYADTLHVLQEFNETYFLGEGDESSMKELTKILHSGEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLTKTFSGDSNVIGGSMVLNPQSRVYEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKETLTNYDMVRCKKEGGYGGLFSLTFHDEDHAAAFYDNLKLNKGPSLGTNFTLAFPYTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKIFQEAIDKTVEI
Protein: Single-pass membrane and coiled-coil domain-containing protein 1 (Single-pass membrane protein with coiled-coil domains 1) (Q147U7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- C-Jun-amino-terminal kinase-interacting protein 3
- WD repeat-containing protein 53
Sequence:
MNNETTTLISLKEAMKRVDHKLQALETQFKELDFTKDNLMQKFEHHSKALASQAAQDEMWTAVRALQLTSMELNILYSYVIEVLICLHTRVLEKLPDLVRGLPTLASVLRRKVKNKRVRVVWESILEECGLQEGDITALCTFFIARGNKAEHYTAKVRQMYIRDVTFLITNMVKNQALQDSLLRAVQVIEKGKAVRTPEKQKSSLEELIPSVKN
Protein: leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (A0A6I8PS05)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNGRLHLGHTFSLSKCESKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
Protein: Translationally-controlled tumor protein homolog (TCTP) (Q9VGS2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in calcium binding and microtubule stabilization.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Probable elongation factor 1-beta
- Elongation factor 1-gamma
- Large ribosomal subunit protein uL6
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein P2
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS9
- 40S ribosomal protein S27
Sequence:
MKIYKDIITGDEMFADTYKMKLVDDVIYEVYGKLITRQGDDIKLEGANASAEEADEGTDITSESGVDVVLNHRLTECFAFGDKKSYTLYLKDYMKKVLAKLEEKSPDQVDIFKTNMNKAMKDILGRFKELQFFTGESMDCDGMVALVEYREINGDSVPVLMFFKHGLEEEKC
Protein: Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A) (MFSD2a) (Q8NA29)
Organism: Homo sapiens (Human)
Function: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26005868, ECO:0000269|PubMed:32572202}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9DA75}; Multi-pass membrane protein {ECO:0000255}. Note=Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane (PubMed:21677192). {ECO:0000269|PubMed:21677192}.
Interaction partners:
- Syncytin-2
- Syncytin-1
Sequence:
MAKGEGAESGSAAGLLPTSILQSTERPAQVKKEPKKKKQQLSVCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQKDEEVVFCFSSFQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELASIL
Protein: Dachshund variant 2 (Q24027)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSVTSEQSENNNNKAGAINNNINSGIERAAGNMNTTAMLMHHQQQQQAAAAAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPRSYNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPERPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPGMPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGSAAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPASSTETLLRNIQSLLKVAADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQLGGGSGAVKGSPNANGSGGGGSGSACSESEACGGGGGDAKCNNNNNNNNNNNNSNSSSHGGDVETMKENDAGSEKSDKSLASNSSCDVTAGHSAGSVSGSISAGLNCPDSPTHFKREPSSDHEGSVERQPRSSAASLAAHDEDNIKRCGSRDRDERPPSGSAASVAAEGSLAAAAAAAAAAAAAAASNGKGPWSYPGIDLMATGAFWQNYSESLAQELEMERKSRAANAERDVKSPLSERPTAYYKNSVLFGSAN