wanglab/gogpt-training-data huggingface dataset:
Protein: Queuosine 5'-phosphate N-glycosylase/hydrolase (EC 3.2.2.-) (Q-nucleotide N-glycosylase 1) (Queuine salvage protein QNG1) (Queuosine-nucleotide N-glycosylase/hydrolase) (Q5T6V5)
Organism: Homo sapiens (Human)
Function: Involved in salvaging queuosine.
Interaction partners:
Sequence:
MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPELRVEGWKALHELNPRAADEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILLEKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY
Protein: At1g65030 (Transducin/WD40 repeat-like superfamily protein) (Q5XEV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome production factor 2 homolog
- Probable ribosome biogenesis protein RLP24
- Ribosome biogenesis protein WDR12 homolog
- U3 snoRNP-associated protein-like YAO
- Putative U3 small nucleolar ribonucleoprotein
- 60S ribosome subunit biogenesis protein NIP7 homolog
- U3 snoRNP-associated protein-like EMB2271
- Probable rRNA-processing protein EBP2 homolog
- Protein HEAT STRESS TOLERANT DWD 1
- F18K10.11 protein
Sequence:
MSIIAGSYERFIWGFKLKPTKHDAESQTLTLSPLFSYPSHISPITTVACSGPAAASGGSDDTIHLYDLPSASSLGSLLDHNHAASITALSFYTPSSLSFPRNLISAAADGSVAIFDTDPFVLLKSFRPHKKAVNDLAIHPSGKLALAVYRDEFFAMLNLVRGKRSFCCRLGHEASLVKFDPSGERFYMVVSNKVGVHQSEDAKLLLELENPSRKRILCATPGESGTLFTGGEDRAITAWDTNSGKLAYSIEDAHPARIKGIVVLTRNDSDGSLEDPYLIGSASSDGIIRVWDVRMAAKENTKPLAETNTKSRLTCLAGSALKSMRRPQIGKQEPQKVDEEHEDSE
Protein: Uncharacterized protein R06F6.12 (Q6BEV5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDSEKENPASPTTGREEEIPGSSPEGVYPADEDHIFHEDQAPLRVESAKHEEEIVEQQQQQPEDLEQGDMIVEDGDQQFMNMVQITQEDMYEAGFDVEAGFELNHLTEEQLNIVVAISQQRQAKQNEQEHNEEVVIEDGSHHHMVHHEMIENQFEGDGNGPEEEYDGNGQIIDNAMHIILTNDGGVNITSKQKQFYVSPSEIANLNIDLNNLSTENVHQLVQLALPPIKEKAQDSAYNDQAPSTSYHHHHHEQLEAGKSTRSPIIGETVQIRTADGRLQDAVVKYVRGDSEYKIQLMNGEFAYATIDQMLVPQRDRSDHEYQQVAPPVLLRRTDMASVRNAAQKRSANDDLCPPVLKKSYQLAPVVDGPHLVHTPNFCCPICDKKVYQKEPSYIVIRLPACDSCTREKIIVLDEQSS
Protein: Transcription regulatory protein (Pca regulon) (Q88N41)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Interaction partners:
- 4-hydroxybenzoate transporter
- Protocatechuate 3,4-dioxygenase beta chain
- Protocatechuate 3,4-dioxygenase alpha chain
- 4-carboxymuconolactone decarboxylase
- 4-hydroxybenzoate 3-monooxygenase
- Transcriptional regulator
- 3-oxoadipate enol-lactonase 2
- HTH-type transcriptional regulator
- 3-oxoadipate CoA-transferase
- BenABC operon transcriptional activator
Sequence:
MSDETLGNDSGNAEVARPASAAMAPPIVASPAKRIQAFTGDPDFMTSLARGLAVIQAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKLGYATTDGRTYSLLPKVLTLGHAYLSSTPLAISAQPYLDRISDQLHEAANMATLEGDDILYIARSATVERLISVDLSVGGRLPAYCTSMGRILLAAMDDTSLREYLERADLKARTSRTLNDPESLFACIQQVRAQGWCVVDQELEQGLRSIAVPVYDASGQVLAALNVSTHVGRVTRSELEQRFLPILLAASRDLCHQLFG
Protein: Gustatory receptor for sugar taste 64e (P83296)
Organism: Drosophila melanogaster (Fruit fly)
Function: One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Gustatory receptor for sugar taste 43a
Sequence:
MARTTGDPAKRRRCMSRIKFWRRSRVGSEVVEKDTKRFKLSLIKAWLLRIRQEDYKYSGSFQEAIKPVLIIAQIFALMPVRKVSSKFAEDLTFTWFSVRSYYALVTILFFGVSSGYMVAFVTSVSFNFDSVETLVFYLSIFLISLSFFQLARKWPEIAQSWQLVEAKLPPLKLPKERRSLAQHINMITIVATTCSLVEHIMSMLSMGYYVNSCPRWPDRPIDSFLYLSFSSVFYFVDYTRFLGIVGKVVNVLSTFAWNFNDIFVMAVSVALAARFRQLNDYMMREARLPTTVDYWMQCRINFRNLCKLCEEVDDAISTITLLCFSNNLYFICGKILKSMQAKPSIWHALYFWFSLVYLLGRTLILSLYSSSINDESKRPLVIFRLVPREYWCDELKRFSEEVQMDNVALTGMKFFRLTRGVVISVAGTIVTYELILLQFNGEEKVPGCFEN
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform (PP2A, B subunit, B' delta 2 isoform) (P78759)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10757751}. Cell tip {ECO:0000269|PubMed:10757751}.
Interaction partners:
- Protein phosphatase PP2A regulatory subunit A
- Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
- Putative serine/threonine-protein phosphatase C26H8.05c
- Protein phosphatase methylesterase 1
- Uncharacterized protein C216.01c
- Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02
Sequence:
MKGLRSKFVKALSLKDEQGSHKNGHSKSHYISKNGSYVETDDVKHTDTHHSSKHELKKLKSHFLKDTLKHKRNHHANSNNEKHENSDKKIHTTVLASGHEDSDYSTFLPVIETSKVKDANHFPPNYPEPKNDSVSSNIDEFPNDSISSASFLSVPQSTPPYLVSQPTPLNKFLAGAENVDIPHSLRPVPRREHSSQFQVSEKRTLVRLPSFDDVHTSEREELFIKKLEQCNIIFDFNDPSSDLASKEIKREALLQMIDYVSENRGISSASLFPYVVNTFSLNVFRPISPALNDYSSDMFALDDEPFLEPAWPHLEEVYLLFIKFLESPDFRASKAKSLVDRRFFNRLLALFDTEDPRERELLKTTLHRIYGKFLNLRSYIRKSMNNVFLQFIYEREKFHGIAELLEILGSIINGFAVPLKEEHKIFLSKVLIPLHQTKSVFLYHPQLTYCIVQFIDKDPSLTKAVLTGILKYWPRINSFKELLFLNEIEDIFEVLEPSEFVNIMSPLFQQLARSISSMHFQVAERALCLWSNEYFTSLVSQNVVTLLPIIYPSLYKTANEHWNSTIQAIACNVLQIFVDMDADFFNGLVEDYKQAIIKQEEVMIIRKQQWCQIEALAAENKPTDYLR
Protein: Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) (J9VWW9)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:33567338}. Note=Localizes to the mitochondrion both in copper-replete and copper-limiting conditions. {ECO:0000269|PubMed:33567338}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:33567338}.
Interaction partners:
Sequence:
MITAITRTALPRATLRTSLATMSTIRAKHTLPPLPYAYDALEPSISAEIMNLHHTKHHQTYVNGLNAAEESLQKASADGDFKTAISLQPALKFNGGGHINHSLFWKNLAPTGSAQVKVPTSGVFYDQVQADFGGFENLKKEMNAKTAAIQGSGWGWLGYNKATKKLEIVTTPNQDPLLSHVPIIGIDIWEHAFYLQYKNVKPDYLNAIWNVINYEEAESRLKAAQ
Protein: Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) (Q9JLR1)
Organism: Mus musculus (Mouse)
Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Translocation protein SEC63 homolog
- Protein transport protein Sec61 subunit gamma
- Protein transport protein Sec61 subunit beta
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS19
Sequence:
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF
Protein: Outer membrane protein P.IIC (Protein IIC) (P09888)
Organism: Neisseria gonorrhoeae
Function: This protein serves as a porin.
Subcellular location: Cell outer membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MQPAKNLLFSSLLFSSLLFSSAARAASEDGGRGPYVQADLAYAAERITHDYPKPTGTGKNKISTVSDYFRNIRTHSVHPRVSVGYDFGSWRIAADYARYRKWNNNKYSVSIKELLRNDNSASGVRGHLNIQTQKTEHQENGTFHAVSSLGLSTIYDFDTGSRFKPYIGMRVAYGHVRHQVRSVEQETEIITTYPSNGGGKVSLSSKMPPKSAHHQSNSIRRVGLGVIAGVGFDITPNLTLDTGYRYHNWGRLENTRFKTHEASLGMRYRF
Protein: Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) (Q9BUG6)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Interaction partners:
Sequence:
MAANCTSSWSLGESCNRPGLELPRSMASSETQLGNHDVDPEISHVNFRMFSCPKESDPIQALRKLTELCHLWLRPDLHTKEQILDMLVMEQFMISMPQELQVLVMMNGVQSCKDLEDLLRNNRRPKKWSVVTFHGKEYIVQDSDIEMAEAPSSVRDDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLLHKSIDVTGDPKSLRPKQTLEKDLKENREENPGLTSPEPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSGNRGDALNLSSPKRSKPDASSISQEEPQGEATPVGNRESPGQAGMNSIHSPGPASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRSHTGERLFQCNLCGKRFMQLISLQFHQRTHTGERPYTCDVCQKQFTQKSYLKCHKRSHTGEKPFECKDCKKVFTYRGSLKEHQRIHSGEKPYKCSKCPRAFSRLKLLRRHQKTHPEATSQ
Protein: Cinnamyl alcohol dehydrogenase 8 (AtCAD8) (EC 1.1.1.195) (NAD-dependent mannitol dehydrogenase 2) (Q02972)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
Interaction partners:
- Flavone 3'-O-methyltransferase 1
- Cinnamoyl-CoA reductase 2
- Cinnamoyl-CoA reductase 1
- Aldehyde dehydrogenase family 2 member C4
- F5F19.5 protein
- Cytochrome P450 84A1
- Protein DETOXIFICATION 39
- UDP-glycosyltransferase 72E3
- UDP-glycosyltransferase 72E2
- Peroxidase 52
Sequence:
MGKVLQKEAFGLAAKDNSGVLSPFSFTRRETGEKDVRFKVLFCGICHSDLHMVKNEWGMSTYPLVPGHEIVGVVTEVGAKVTKFKTGEKVGVGCLVSSCGSCDSCTEGMENYCPKSIQTYGFPYYDNTITYGGYSDHMVCEEGFVIRIPDNLPLDAAAPLLCAGITVYSPMKYHGLDKPGMHIGVVGLGGLGHVGVKFAKAMGTKVTVISTSEKKRDEAINRLGADAFLVSRDPKQIKDAMGTMDGIIDTVSATHSLLPLLGLLKHKGKLVMVGAPEKPLELPVMPLIFERKMVMGSMIGGIKETQEMIDMAGKHNITADIELISADYVNTAMERLEKADVRYRFVIDVANTLKPNPNL
Protein: Nucleolar protein 9 (Pumilio domain-containing protein NOP9) (P47077)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: RNA-binding nucleolar protein required for pre-rRNA processing. Component of the 90S pre-ribosome involved in production of 18S rRNA and assembly of small ribosomal subunit. Component of the pre-40S ribosome required for release from the nucleolus.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17956976}.
Interaction partners:
- Essential nuclear protein 1
- Multiple RNA-binding domain-containing protein 1
- Something about silencing protein 10
- Protein BFR2
- Ribosome biogenesis protein MAK21
- ATP-dependent RNA helicase HAS1
- Ribosome biogenesis protein ERB1
- Ribosome biogenesis protein SLX9
- Ribosome biogenesis protein ENP2
- Ribosome biogenesis protein TSR1
Sequence:
MGKTKTRGRRHQDKQRKDEFEPSSNSAKEHIQQEESTYNDEAEIKETQPQMFFGVLDREELEYFKQAESTLQLDAFEAPEEKFQFVTSIIEEAKGKELKLVTSQITSKLMERVILECDETQLKDIFQSFNGVFFGLSCHKYASHVLETLFVRSAALVERELLTPSFDNNEKEGPYVTMENMFLFMLNELKPHLKTMMNHQYASHVLRLLILILSSKTLPNSTKANSTLRSKKSKIARKMIDIKDNDDFNKVYQTPESFKSELRDIITTLYKGFTNGAESRSDISQSTITKFREYSVDKVASPVIQLIIQVEGIFDRDRSFWRLVFNTADEKDPKEESFLEYLLSDPVGSHFLENVIGSARLKYVERLYRLYMKDRIVKLAKRDTTGAFVVRALLEHLKEKDVKQILDAVVPELSMLLNSNMDFGTAIINASNKQGGYLRDDVIAQLIQKYYPEKSDAKNILESCLLLSASTLGNTRDDWPTAEERRRSVFLEQLIDYDDKFLNITIDSMLALPEERLIQMCYHGVFSHVVEHVLQTTRVDIIKRKMLLNILSKESVNLACNVYGSHIMDKLWEFTAKLTLYKERIARALVLETEKVKNSIYGRQVWKNWKLELYVRKMWDWKKLIKEQEFEIFPNSKPLQPKPEKHSRERNNSKEGSAFKKQKHYR
Protein: LIM and SH3 domain protein Lasp (Q8I7C3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Yuri gagarin, isoform B
- Dynamin
- Tropomyosin-1, isoforms 9A/A/B
- Calmodulin-related protein 97A
- Proteasome inhibitor PI31 subunit
- Cortactin, isoform A
- Myosin heavy chain 95F
- AT09290p
- PFTAIRE-interacting factor 1A, isoform H
- Eukaryotic translation initiation factor 3 subunit M
Sequence:
MNKTCARCQKVVYPIEELKCLDKTWHKTCFKCTECGMTLNMKTYKGYNKMPYCEAHIPKAKATAIADTPELKRIAENTKIQSNVKYHADFEKAKGKFTQVADDPETLRIKQNTKHISNVAYHGDLEKKAAMEKQRGSAEVSDSSNESEYFSEQLAAEQFSQYAPTASPIPPAATTLHQQQQQLQHQQQQQYQQHQQQLQQQQHQHQHYLQQQQQTLPPPPIQHQQYNTAAITPTYQQLQQQQQQQQQQRAQQQQLHDPYAHYQQPQALRQQQQQQQQQQQQLLQQQAIKQASHLYPTATSQQQQMPPPQSPANPQQQALNSYNEMRSAILQNSHHPSGNSVDQYDQPQQQQHQPQQQSTNPTLVAAQQQQSHHSLLNNNASNGGISHSHHSNINNNGHGSQNQMLPPQMRRSAASVVAYDGNSKQQVAAGPGAAQNHLQQLYASPNYAAVTPSENSINVKQHASNGHMPNQQQQHVAGGSNIGKIADYDPLTDGPRVVPNAGRSSTTLVYSSEPRGNQGGNSVYPKRIGSVSDIDPANGIYGSLTAAEQAHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSYSSLQEKQSRQSTAMRVYRAIYDYEAQDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPANYVEQAVI
Protein: Probable protein kinase At2g41970 (EC 2.7.11.-) (P93749)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Calcium-dependent protein kinase 25
- Protein ROH1A
- Serine/threonine-protein kinase RHS3
- Serine/threonine-protein kinase AGC1-7
- Serine/threonine-protein kinase AGC1-5
- RNA-binding motif protein 25
- Kinesin-like protein KIN-UC
- Xyloglucan endotransglucosylase/hydrolase protein 14
- Expansin-A7
- CRIB domain-containing protein RIC1
Sequence:
MFCCGGADEEPAGPPANQYAAPPNKAGNPNFGGGNRGEPRNPNAPRSGAPAKVLPIEIPSVALDELNRMAGNFGNKALIGEGSYGRVFCGKFKGEAVAIKKLDASSSEEPDSDFTSQLSVVSRLKHDHFVELLGYCLEANNRILIYQFATKGSLHDVLHGRKGVQGAEPGPVLNWNQRVKIAYGAAKGLEFLHEKVQPPIVHRDVRSSNVLLFDDFVAKMADFNLTNASSDTAARLHSTRVLGTFGYHAPEYAMTGQITQKSDVYSFGVVLLELLTGRKPVDHTMPKGQQSLVTWATPRLSEDKVKQCIDPKLNNDFPPKAVAKLAAVAALCVQYEADFRPNMTIVVKALQPLLNSKPAGPESTS
Protein: ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) (Q8BVU5)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- ADP-sugar pyrophosphatase
- Ribose-phosphate pyrophosphokinase 1
- Transient receptor potential cation channel subfamily M member 4
- Ribose-phosphate pyrophosphokinase 2
- ribose-phosphate diphosphokinase
- Ribose-phosphate pyrophosphokinase 1
- Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
- Phosphoglucomutase-1
- Phosphopentomutase
- Transient receptor potential cation channel subfamily M member 8
Sequence:
MAGRSLGQAVATVSLSVALASVTVRSSACRAVPAPRNTFPTCGFHLNANIMSGSNGAKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYNPVEYTAVSVLAGPQWADPQISESNFSPKFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGETMDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEKRDAHWSEDHAADSRGL
Protein: ATP-dependent Clp protease proteolytic subunit 3, chloroplastic (EC 3.4.21.92) (Endopeptidase ClpP3) (nClpP3) (nClpP4) (Q9SXJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). In the absence of CLPP3, modified ClpPR core(s) could be formed, albeit at strongly reduced levels.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:11982939, ECO:0000269|PubMed:14593120}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 5, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic
- Chloroplastic ATP-dependent Clp protease proteolytic subunit 1
- ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic
- CLP protease regulatory subunit CLPX1
- Chaperone protein ClpC1, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 3, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 4, chloroplastic
Sequence:
MEMSLRLASSSTSNPICLLNPGKNLNFPIRNHRIPKTSKPFCVRSSMSLSKPPRQTLSSNWDVSSFSIDSVAQSPSRLPSFEELDTTNMLLRQRIVFLGSQVDDMTADLVISQLLLLDAEDSERDITLFINSPGGSITAGMGIYDAMKQCKADVSTVCLGLAASMGAFLLASGSKGKRYCMPNSKVMIHQPLGTAGGKATEMSIRIREMMYHKIKLNKIFSRITGKPESEIESDTDRDNFLNPWEAKEYGLIDAVIDDGKPGLIAPIGDGTPPPKTKVWDLWKVEGTKKDNTNLPSERSMTQNGYAAIE
Protein: Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (EC 6.2.1.17) (Acetate--CoA ligase 3) (Propionate--CoA ligase) (A0A0B4J1R2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTIEDPSIFGHVEEMLKQA
Protein: Zinc finger CCCH domain-containing protein 4 (Q9UPT8)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs.
Subcellular location: Chromosome {ECO:0000269|PubMed:33913806}. Note=Recruited at sites of high RNA polymerase II occupancy. {ECO:0000269|PubMed:33913806}.
Interaction partners:
- WD repeat-containing protein 82
- Homeobox protein goosecoid
- Symplekin
Sequence:
MEAAPGTPPPPPSESPPPPSPPPPSTPSPPPCSPDARPATPHLLHHRLPLPDDREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHATPLPKKAYSKMDSKSYGMYEDYENEQYGEYEGDEEEDMGKEDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGSRGRGRGSMGGDHPEDEEDFYEEEMDYGESEEPMGDDDYDEYSKELNQYRRSKDSRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDEDMGDGGGGSYRSRDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPQAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPMPVHEPLSPQQLQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHADMHADMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLLGDAEDYGHYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPPASVGELSSSGLGDPRLQKGHPTGSRLADPRLSRDPRLTRHVEASGGSGPGDSGPSDPRLARALPTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVNIPLDPLPGHPLRDPRSQLQQFSHIKKDVTLSKPSFARTVLWNPEDLIPLPIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPFVRKSALEQPETGKAGADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQTPKTGSGSPFAGNSPAREGEQDAASLKDVFKGFDPTASPFCQ
Protein: Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) (P32301)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1326760, ECO:0000269|PubMed:7813606}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43220}.
Interaction partners:
- Pro-glucagon
- Gastric inhibitory polypeptide
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
- Pituitary adenylate cyclase-activating polypeptide
- Dipeptidyl peptidase 4
- Natriuretic peptides A
- VIP peptides
- Glucagon-like peptide 2 receptor
- Neuroendocrine secretory protein 55
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
Protein: Calreticulin (Q584K4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319, ECO:0000256|PIRNR:PIRNR002356}.
Interaction partners:
- Lipophosphoglycan biosynthetic protein, putative
- Calreticulin
- Uncharacterized protein
- Heat shock protein, putative
- Glucose-regulated protein 78, putative
- UDP-glucose:glycoprotein glucosyltransferase, putative
- Protein disulfide isomerase
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein
- Elongation factor 2
- alpha-1,2-Mannosidase
Sequence:
MLMCMRPVAVACVFVALATVATVHGAIHFHEKFSSIDHWTASKARSDYGKVELSAGKFYADAEKSKGLRLTEDARFYALSTPLPTPITNEKKDFVVSFSVKHEQDLRCGGGYIKLLPQMDPAELKGETKYWLMFGPDRCGYDKKIHIIISYNGANREWKKRPSYPDDRLTHVYTLHITPSNSYEFFLDGVSKEKGTLEADWDFLPEKEIDDPEDKKPADWVDVPTIDDPEDKKPEDWDSEPEKIVDPEAKKPEDWNDAEDGAWEAPMISNPKSKGPWAPRKIPNPAYKGPWAPRRIPNPAYKNDEELYKIPEPLTHVGIDVWQVESGSIFKDIIIGDDVKEVLDIVKSTYDGMKKAEEDALAAFEKKEEQDEKEEDKKETDGEEDKKKKEDKSDL
Protein: Cytochrome b-c1 complex subunit 8, mitochondrial (Complex III subunit 8) (A0A1D8PHA2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:19824013}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P08525}; Single-pass membrane protein {ECO:0000250|UniProtKB:P08525}.
Interaction partners:
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b
- Cytochrome c oxidase subunit 8, mitochondrial
- Cytochrome c oxidase subunit
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome c oxidase subunit Va
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome b-c1 complex catalytic subunit, mitochondrial
Sequence:
MAGAPHPHTYMGWWGSLGSPKQKYITQYTISPYAAKPLKGAAYNAVFNTFRRTKNQFLYVAIPFVVVWSIWTRARDYNEYLYTKEGREELERVNV
Protein: Ran-specific GTPase-activating protein 1 (Chromosome stability protein 20) (Perinuclear array-localized protein) (Ran-binding protein 1) (RANBP1) (P41920)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm.
Interaction partners:
- GTP-binding nuclear protein GSP1/CNR1
- Ran GTPase-activating protein 1
- Exportin-1
- Guanine nucleotide exchange factor SRM1
- GTP-binding nuclear protein GSP2/CNR2
- Peptidyl-prolyl cis-trans isomerase
- Nuclear transport factor 2
- Peptidyl-prolyl cis-trans isomerase C, mitochondrial
- Importin subunit alpha
- Peptidyl-prolyl cis-trans isomerase D
Sequence:
MSSEDKKPVVDKKEEAAPKPPSSAVFSMFGGKKAEKPETKKDEEDTKEETKKEGDDAPESPDIHFEPVVHLEKVDVKTMEEDEEVLYKVRAKLFRFDADAKEWKERGTGDCKFLKNKKTNKVRILMRRDKTLKICANHIIAPEYTLKPNVGSDRSWVYACTADIAEGEAEAFTFAIRFGSKENADKFKEEFEKAQEINKKA