wanglab/gogpt-training-data huggingface dataset:
Protein: Ectodysplasin-A receptor-associated adapter protein (EDAR-associated death domain protein) (Protein crinkled homolog) (Q8WWZ3)
Organism: Homo sapiens (Human)
Function: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member EDAR
- TNF receptor-associated factor 6
- Ectodysplasin-A
- Protein Wnt-10a
- Tumor necrosis factor receptor superfamily member 27
Sequence:
MGLRTTKQMGRGTKAPGHQEDHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTITLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF
Protein: Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Q5RIW8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 4
Sequence:
METQLQSIFEDVVKTEVIEEAFAGMFMDSPEDEKTKLTSCLGAFRQFWSTLPQESHEQCVQWIVRFIHGQHSPKRIAFLYDCLAMAVETSLLPPRMVCQALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPNFVSSAVVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLCPEGALSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPYDKDLFDPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALGDFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPIQLQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKCGMNAREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSAVLSSGSDWLGYPFQLLDFTACHQSYSEMHCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSNHLAYMDPICDFLYHIKYMFTGDSVKDQVERIICSLRPAMRLRLRFITHISKMEPAAVPVSNSSSVQQTSSASSPTAQSTAGAAIPLSVTQ
Protein: Probable receptor-like protein kinase At3g17420 (EC 2.7.11.1) (Q9LRP3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754}; Single-pass type I membrane protein {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754}.
Interaction partners:
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform
- E3 ubiquitin-protein ligase SINAT3
- Purple acid phosphatase 7
- Probable protein phosphatase 2C 36
- Pseudouridine kinase
- ARP protein
- Probable protein phosphatase 2C 66
- Enoyl-CoA delta isomerase 1, peroxisomal
- 4-coumarate--CoA ligase-like 2
- Peroxisomal nicotinamide adenine dinucleotide carrier
Sequence:
MTSQLKRTLTKRYGVLELWEIIVIALFAAFIVILVLSVWLSFRKKSKRSNATTLPVTQSPRFTEEIKEISVDHGSSNNNGTSYQTLDEKFVEDIENGDKFSGSLEKKPLVGSHLPPSTPSTTAPSPLLGLPEVSHIGWGHWFTLRDLQLATNHFSKESIIGDGGYGVVYHGTLTNKTPVAVKKLLNNPGQADKDFRVEVEAIGHVRHKNLVRLLGYCVEGTHRMLVYEYMNNGNLEQWLHGDMIHKGHLTWEARIKVLVGTAKALAYLHEAIEPKVVHRDIKSSNILMDDNFDAKLSDFGLAKLLGADSNYVSTRVMGTFGYVAPEYANSGLLNEKSDVYSYGVVLLEAITGRYPVDYARPKEEVHMVEWLKLMVQQKQFEEVVDKELEIKPTTSELKRALLTALRCVDPDADKRPKMSQVARMLESDEYPVMPREERRRRRNQNAETHRESTDTNKDNDITTDAKI
Protein: Serine/threonine protein phosphatase 2A regulatory subunit B''alpha (AtB''alpha) (PP2A, B'' subunit, alpha isoform) (Q9XGR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory subunit of type 2A protein phosphatase. Not involved in HMGR regulation in seedlings grown in standard medium, but negatively regulates root growth in response to salt.
Interaction partners:
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform
- Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
Sequence:
MEIDGGNDVQILDPELLQLPGLSPVSLKENPHIAEELFSQWLSLPETGRLVKSLIDDTKSSTPVSVSKNCTSLNVACGSALPSVFLNSGTPPLSPRGSPGSPRFSRQKTSPSLQSPLKSVREPKRQLIPQFYFQHGRPPAKELREQCISMVDQFFSNYIDGLHMDEFKSITKEVCKLPSFLSSVLFRKIDTSGTGIVTRDAFIKYWVDGHMLAMDVASQIYNILRQPGCKYLRQADFKPVLDELLTTHPGLEFLRNTPEFQERYAETVIYRIFYYINRSGTGCITLRELKRGNLITAMQQVDEEDDINKVIRYFSYEHFYVIYCRFWELDGDHDFLIDKENLIKYGNHALTYRIVDRIFSQVPRKFTSKVEGKMSYEDFAYFILAEEDKSSEPSLEYWFKCIDLDGDGVITPNEMQFFYEEQLHRMECITQEPVLFEDILCQIFDMIKPEKENCITLQDLKASKLSGNIFNILFNLNKFMAFETRDPFLIRQERENPTLTEWDRFAQREYVRLSMEEDVEEVSNGSADVWDEPLESPF
Protein: Small ribosomal subunit protein eS12B (40S ribosomal protein S12-B) (O74322)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL10
- mRNA export factor elf1
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Elongation factor 3
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein eS27
Sequence:
MSTEGDHVPQAEEVIETVEVVEEETGSSPLSVEDSLKEVLKRALVHDGLARGIREASKALDRRQAHLCVLCESCDQEAYVKLVEALCAESQTPLVKVADPKILGEWAGLCVLDRDGNARKVVGCSCVAVTDYGEDSVALQTLLSSFAA
Protein: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (I-19) (NIM-R5 antigen) (CD antigen CD38) (P56528)
Organism: Mus musculus (Mouse)
Function: Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity (By similarity).
Subcellular location: Membrane {ECO:0000305|PubMed:11829748, ECO:0000305|PubMed:8376770}; Single-pass type II membrane protein {ECO:0000305|PubMed:8376770}.
Interaction partners:
- Platelet endothelial cell adhesion molecule
- Nicotinamide phosphoribosyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
- NAD-dependent protein deacetylase sirtuin-1
- T-cell ecto-ADP-ribosyltransferase 2
- NAD-dependent protein deacetylase sirtuin-3
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Nicotinamide N-methyltransferase
Sequence:
MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVILLRPRSLLVWTGEPTTKHFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNPCNITREDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYVSCPHWSENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLREPFYKNSTFGSVEVFSLDPNKVHKLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMIFACVDNYRPARFLQCVKNPEHPSCRLNT
Protein: CIN85 and CD2AP related, isoform J (A0A0B4KI34)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
- Anillin
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Phosphatidylinositol-binding clathrin assembly protein LAP
- Dynamin
- LD44138p
- GM01519p
Sequence:
MENNICAIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVSSNGNGTTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAANVANVAATATVPTGGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIVSGSGAAAGGGAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVKMLAPSEATAAPPLPRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFITTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGGAGSASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEPRGASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIMSRSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQLNNHQDASSSRVAQLEQRVDKLEGLVLNQQRTIEELVNALKSEAERVKILRSELDKYAQCVTQV
Protein: Pantothenic acid transporter PanT (Pantothenic acid ECF transporter S component PanT) (A2RIQ0)
Organism: Lactococcus lactis subsp. cremoris (strain MG1363)
Function: Probably a pantothenic acid-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21135102}; Multi-pass membrane protein {ECO:0000305|PubMed:21135102}.
Interaction partners:
- Energy-coupling factor transporter ATP-binding protein EcfA2
- Energy-coupling factor transporter ATP-binding protein EcfA1
- Energy-coupling factor transporter transmembrane protein EcfT
- Thiamine transporter ThiT
- Thiamine precursor transporter HmpT
- Putative phosphopantothenate--cysteine ligase
- Putative DNA/pantothenate metabolism flavoprotein
- Niacin transporter NiaX
Sequence:
MKKSKASDVAILAIFIAIMVVVQLFTQFVINVWPFPVKPTLLHLPVIIGSIILGWRKGAFLGLVWGLISFVTATIVTTPTSFLFSPFQPVIGTHHGSPWGLFIAFIPRILVGILPYFVYKIANNRLGAGLAAFAGTATNTVLVLTSIFLFFGSTLKWSLSYLLGAIVATNSLTEVIIAVILTTAIVPALTKARNNS
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (Q24468)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
Sequence:
MSKYDLLYLTAQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHECNQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVGMGLLLYRRRKQAHFNEIPTHEAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNHTNIDDAKESTNCL
Protein: Prokaryotic phospholipase A2-domain-containing protein (Q2U4B8)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
Sequence:
MKANSFLIALLPTALAIPLPTPNEGATSLSESQRLQSITDELMFGLELPDFTARREANDPPQLDWYSDGCTRAPSNPLGFPFQRACERHDFGYQNYRIQGRFTKAAKAQIDLRFKEEYDFPFVPSFSPGICFC
Protein: NAD(P)H nitroreductase (A0A0H3LDV7)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Interaction partners:
Sequence:
MNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSRPDMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQPLVPDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMKAIVAQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLSQPSDVLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIAKTRDAVRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC
Protein: Ubiquitin like modifier activating enzyme 2 (U3KQ93)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
Protein: Bifunctional purine biosynthesis protein ATIC (EC 2.1.2.3) (EC 3.5.4.10) (AICAR transformylase/inosine monophosphate cyclohydrolase) (Q9VC18)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- Serine hydroxymethyltransferase
- Trifunctional purine biosynthetic protein adenosine-3
- Phosphoribosylformylglycinamidine synthase
- Adenylosuccinate lyase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Adenylosuccinate synthetase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
- Adenine phosphoribosyltransferase
- Inosine-5'-monophosphate dehydrogenase
- Aminomethyltransferase
Sequence:
MSSSKIALLSVSDKTGLLDLGKSLVALGFDLVASGGTATSLRGAGLKVRDVSEITGAPEMLGGRVKTLHPAVHAGILSRTTDSDLADMRKQGFDLIQLVVCNLYPFASTVAKPDVTLADAVENIDIGGVTLLRAAAKNHQRVTVVCEAVDYDRVLSELKASGNTTVETRQALALKAFTHTATYDDAISDYFRKQYGSGVSQLPLRYGMNPHQKPAQLYTQLAKLPLTVLNASPGFINLCDALNGWQLVRELKKALQLPAATSFKHVSPAGAAVGVPLNPAQAKLCMVDDLYEQLTPLATAYARARGADRMSSFGDFVALSDVCDVVTARIISREVSDGIIAAGYEPEALEILKKKKNGGYCILQMDPNYEPSAVERKTIFGLTLEQKRNDAVIDASLFSNVVSKRGPLPEVAVRDLIVATIALKYTQSNSVCYARDGQVVGIGAGQQSRIHCTRLAGEKADNWWLRQHPSVAGMKFKAGVKRAEISNAIDNYVNGTVGKDMPLSQFEGMFDKAPAQLTSEQKVEWLKQLSGVALGSDAFFPFRDNIDRASLSGVSYIASPAGSTNDAGVIAACDEHGIIMAHTNLRLFHH
Protein: Uncharacterized protein (O05888)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Lipoprotein LpqB
- DNA-binding response regulator MtrA
- Phosphoribosyltransferase
Sequence:
MSPRVPRLRWDDPFRALDMLASLWSSTGMSLVSAGAAQAVAAPYRTLFTTLQQLLIGKEVTVRIGDHDVVLTVTELDSALEPQGLAVGQLGEVRVAARGISWDQHHLHSAVAVLRNVHIRPGVPPLVIAAPVELSSALPTEIFDDVLRQATPQLRGELSESGAARLRWARRPDWGGLEVDVDVAGTTSQTTLWLRPRTVITGQRRWTLPARTPAYRVPLPELPHGLRITDVSLAADCLQLSALLPEWRTELPLRYLESVITQLSQGALSFVWPPLRSGAD
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Somatomedin) (P18254)
Organism: Gallus gallus (Chicken)
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
Subcellular location: Secreted.
Interaction partners:
- Tyrosine-protein kinase receptor.
- Tyrosine-protein kinase receptor
- Insulin
- Uncharacterized protein.
- Uncharacterized protein.
- Hepatocyte growth factor
- Platelet-derived growth factor subunit A
- Vascular endothelial growth factor C
- Platelet-derived growth factor C
- Vascular endothelial growth factor D
Sequence:
MEKINSLSTQLVKCCFCDFLKVKMHTVSYIHFFYLGLCLLTLTSSAAAGPETLCGAELVDALQFVCGDRGFYFSKPTGYGSSSRRLHHKGIVDECCFQSCDLRRLEMYCAPIKPPKSARSVRAQRHTDMPKAQKEVHLKNTSRGNTGNRNYRM
Protein: Qa-SNARE protein (Q4Q8B8)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
- Putative Sec1/Munc18 related protein
- Putative Qc-SNARE protein
- t-SNARE coiled-coil homology domain-containing protein
- Qa-SNARE protein
- Qa-SNARE protein
- Putative SNAP protein
- Soluble NSF attachment protein, SNAP family protein
- Putative SNAP protein
- Putative SNARE protein
- Putative QA-SNARE protein
Sequence:
MAELQQKHTENMQTVDEARSKALRGEIDELSRETGNAAKAAKEKLDAMSKNTAKLKSVPDSVQANSAIIRIEENQYTHLVLKLTMAMAEYQRQQSANEAYYKAQTQRQIKIKYTNPDGSAIDDSTAAQLAEQVMENDTSSYIFQQSKEVLASIIETRNDIYRIEQSMRDLNQLFNDLAFLVNEQGELMDVILANVQQSTRYVAKGRAALKKARRYQKKSRKKLRCSVLRKEYVEKTAVAYSPWQEASVQVHRHCCPEGEKWAAWED
Protein: Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e) (P43629)
Organism: Homo sapiens (Human)
Function: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Killer cell immunoglobulin-like receptor 3DL3
- HLA class I histocompatibility antigen, A alpha chain
- HLA class I histocompatibility antigen, B alpha chain
- Killer cell immunoglobulin-like receptor 2DL3
- HLA class I histocompatibility antigen, C alpha chain
- Killer cell immunoglobulin-like receptor 2DL1
- Killer cell immunoglobulin-like receptor 3DL2
- Natural killer cells antigen CD94
- Beta-2-microglobulin
- NKG2-A/NKG2-B type II integral membrane protein
Sequence:
MSLMVVSMACVGLFLVQRAGPHMGGQDKPFLSAWPSAVVPRGGHVTLRCHYRHRFNNFMLYKEDRIHIPIFHGRIFQESFNMSPVTTAHAGNYTCRGSHPHSPTGWSAPSNPVVIMVTGNHRKPSLLAHPGPLVKSGERVILQCWSDIMFEHFFLHKEGISKDPSRLVGQIHDGVSKANFSIGPMMLALAGTYRCYGSVTHTPYQLSAPSDPLDIVVTGPYEKPSLSAQPGPKVQAGESVTLSCSSRSSYDMYHLSREGGAHERRLPAVRKVNRTFQADFPLGPATHGGTYRCFGSFRHSPYEWSDPSDPLLVSVTGNPSSSWPSPTEPSSKSGNPRHLHILIGTSVVIILFILLLFFLLHLWCSNKKNAAVMDQEPAGNRTANSEDSDEQDPEEVTYAQLDHCVFTQRKITRPSQRPKTPPTDTILYTELPNAKPRSKVVSCP
Protein: Neurogenic locus notch homolog protein 3 precursor (Notch3) (Q800E4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGNYSLWIFLSILYLVHNSEGLLCVDTHRPCENGGMCIDSRCLCRPGYIGSLCQHLDPCHRSPCLNAAACKSQVANSIPQYTCVCQRGFRGQDCSLVDACATSPCANGARCTNWNNHYNCSCPPGYQGKNCRNDIDECRKPGKCLNGGICMNTHGSFRCECLTGYSGRTCEVPTQPCAPSQCLNGGTCHQTGDHTYECACLPGFRGHNCEDNVDDCPGHKCMNNGICVDGVNTYNCQCPPEWTGQYCAEDVNECLMQPNACHNGGTCFNTIGGHTCVCVNGWTGDDCSENIDDCATAVCFNGATCHDRVASFFCECPVGKTGLLCHLDDACVSNPCNEGAVCDTNPLNGRAICTCPAGFVGGACNQDMDECSIGANPCEHFGKCVNTEGSFQCQCGRGYTGPRCEIDINECLSMPCQNDATCLDRIGEFTCICMPGYQGKYCEVDIDECESNPCVNDGICRDMVNGFTCTCQPGFTGTMCQIDIDECASTPCQNGAKCIDRPNGYECRCAEGFEGRLCESNIDNCKPDPCHHGTCVDGIASYTCNCEPGYTGYRCENQLNECHSNPCQNGGKCVDLVNKYICQCQHGTSGTNCEINFDDCASNPCDYGICKDGINRYECVCKPGFTGPQCKDEIDECQSNPCRNGGTCVDDENGFHCQCPEGFHDPYCYSQVDECASNPCLHGTCRDDPNGYRCDCEPGWVGKNCDLDRNDCLPSPCQNAGTCFDQLNGFTCKCRQGFRGNLCQVNINECASSPCLNQGTCVDGVASFTCLCEPPYSGPTCAELLTPCSPNPCANHASCVHTPDYLGYQCNCQPGWQGHLCNNDINECTSNPCKNRGTCTNTLGGYVCSCRAGYTGPNCETDINDCSPNPCLNGGSCTDGVNSFRCSCLPGFTGARCATELNECQSVPCKNGGTCTDYVNSYTCTCKPGFTGLLCETNVPDCTESSCFNGGTCTDGINGFKCTCRTGFTGDYCQYEVNECDSQPCLNGGICQDAMESYRCSCPKGYTGPRCQYPVDWCRPSNPCKNGGRCRQKDASFTCDCLGGWSGRYCDIPGVSCEVAARQRGRQTDELCLHGGHCVNTGNTHYCKCPADYTGSYCESQFDHCEEKPCLNGATCRSYMGGFTCDCMPGYEGNNCEREVNECQSHPCQNGGTCIDLVGHYICSCPPGTLGVLCEINEDDCATPSWPRGMPKCQNNGTCVDRVGGYRCNCPPGFTGERCEGDINECLSNPCNPSNSLDCIQLPNDYQCVCKPGFTGRGCQSRFSVCESQPCKNGGVCSLSGSSPPGYSCTCQLGYAGSNCERSMNCKELPCYNGGSCTLTTRGARCTCIQGFGGPLCQHRSNDGCSSKPCHNGGLCTEETSYPFFHCQCTNGWKGKRCEQKTGSSAPLPSPCPIADCFSKANDGVCDKECNSLDCRWDGGDCSLAVNPWARCADPRCWRLFNNSQCDEFCNNAECLFDNFDCINKEKVCNPIYEAYCTDHYADGLCDQGCNTEECGWDGLDCARKIPEDLAEDMLVIVVLLPPEELLRTQTAFLQKLSAILRTTLRFRLDRNGDYMIRPYTGRETRIKRELNPQEVIGSIVYLEIDNRLCSQGSDDCFRNADSAAEYLGALSAREMLRFPYPIKEVTSEKREPSITEIPEWARLLLVGVASLFLLVILMVGMLIARRKREHSTLWFPEGFFLKKETSSNKNRREPVGQDSLGMKHMPKTVEESLLADHSDQWIDTDCPEAKRLKVEEPSILSDGEDAVDSRQWTQHHLAAADIRMPPSMALTPPQGEFDSDCMDVNVRGPDGFTPLMLASFCGGGLEPEVTEDDDSDESSANIISDLIYQGASLAAQTDRTGETALHLAARYARADAAKRLLDAGADANAQDNTGRSPLHAAVAADAQGVFQILIRNRATDLDARMYDGSTALILAARLAVEGMVEELITCHADVNAVDEIGKSALHWAAAVNNVEATIALLKNGANKDMQDLKEETPLFLAAREGSCEAVKVLLAHFANREITDHMDRLPRDIAQERMHHDIVQLLDEYNTVRSPQGHAGAGHHLSGSHTLSPLMCPPSNFLQGLKSTPQGKKNRRPGAKGIGGQHASGLKDSAKGRNKRLTLDMQSALLESSVTLSPVDSLDSPRGGASNAGYVTNPTSPAAMPSPGLFHSSMSVPNTPMVHSSILDSTSPFSVSLAQLSDLGDGGLSMQGRVGMQGGGVNPGPHNYVMNAGQMSLSMGMVSPVSVPFDWHNRMPPSSQCSQPMISMVHPVSSQAGMLPQTPTLQSSMLLHQQVFRNAQQPILQPTPVSSTPSISPVKLPPIAEQQPQQLHSHTLTNPNLSRMATSTPPTPQQAQPPPAFYQPQQPQAQPPQAPTAPQATQAQAIPSQAPPAQVSGSTAGPEDYPTPPSQHSYSSAMDATPKHYLHVPNEHPYLTPSPESPEPWSSPSPHCVSDWSDSTPSPAVTAPSQTQISQVQESNGKMQVFA
Protein: SD25427p (Q8MRT9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLTGFSPESAETQICNTDVDGCLDKIPFIWKDFKKDGYLTAYAEDEEHSNTFNYAKPGFAVKPTDYYFRPFLTALENETFIQYCPGCVMKYCLGRRLASSYIFDYCRQFMQRFVADRPIWGMFWTNHYSHDDLFMLSAMQHKILEDLLSFEKDGAFEHTIMIFFSDHGARFGPLMYTKEAFLEERLPMMFIYLPPWFRKKYPRYVEALAQNQNRLSSNFDLYNTLKHIINIEGLVEDTKWSYDCPQCQSLFYPLPESRSCSEAAIPEAYCTCHNYEEIKEDQGTWRLANLVVDRMNKYLHYHNLQNLCSNLTLRVINSTEVRMDDKDVDLANGMRHYHTKFQVHQNLAEFFATVLYDKQTEELQMNVELISRTNMYGTDSECVNNKIQKLYCVCLSKLRAIIK
Protein: Non-structural protein 1 (NS1) (NS1A) (P03502)
Organism: Influenza B virus (strain B/Lee/1940)
Function: Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04066}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04066}.
Interaction partners:
Sequence:
MADNMTTTQIEVGPGATNATINFEAGILECYERFSWQRALDYPGQDRLHRLKRKLESRIKTHNKSEPENKRMSLEERKAIGVKMMKVLLFMDPSAGIEGFEPYCVKNPSTSKCPNYDWTDYPPTPGKYLDDIEEEPENVDHPIEVVLRDMNNKDARQKIKDEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGDKSLSTLHRLNAYDQNGGLVAKLVATDDRTVEDEKDGHRILNSLFERFDEGHSKPIRAAETAVGVLSQFGQEHRLSPEEGDN
Protein: Zinc finger protein 472 (A0A0G2K9F4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MISLGLLLGKTEEEDNEEYQNPKGSLRTLMVERLCKYHHGNQYGETQRQSPDHVVSEKMPPAVSECERDILIHLPSDMHFKGQTGEKPCQYQEQMEKTLKHKKCWKDFSYSELLWMHKNPPMKQKPHENKEANEASRSFTSDHDYEGTFTEEKSYICKQCGKAWSDSCSLLWHERSHIQEKRHTCKQCGKAFSRPSQLHKHERIHTGEKPYVCTHCGKAFIDRRTCHNHERTHTGVKPFACKQCGKAFLRSCQLLIHERIHTGERPFVCKHCGKAFTYSSACYYHERIHTGEKPCVCKQCGKAFKCSAYLHIHERSHSGEKPYVCKHCGKAFAYATGCHKHERIHTGEKPYMCVQCGKLFTFPRSLHIHERSHSGEKPYVCKQCGKSFTQGTSLRRHERIHTGEKPYVCRQCGKAFIQRDDCYSHERTHTGEKPFMCVQCGKTFTFSKSLQIHEKNHTGEKPYICKQCGKAFTCSTYLLRHERTHSEKKLSG