wanglab/gogpt-training-data huggingface dataset:
Protein: Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3) (Q9UMX2)
Organism: Homo sapiens (Human)
Function: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).
Subcellular location: Nucleus. Cytoplasm {ECO:0000250}.
Interaction partners:
- Antizyme inhibitor 1
- Ornithine decarboxylase
- Antizyme inhibitor 2
- Gametogenetin-binding protein 2
- Outer dense fiber protein 1
Sequence:
MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
Protein: Serine/threonine-protein kinase TDA1 (Topoisomerase I damage affected protein 1) (EC 2.7.11.1) (Q03533)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine/threonine protein kinase shown to have protein phosphorylation activity in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Fumarate hydratase, mitochondrial
Sequence:
MTTASSSASQLQQRLPEEKPWPQLSGSNADAQTFKCKYVTNHNSLGDGNFSVVKECMNIHTKDLYAMKLIKKQTVKNKIQLIQREFDLLRSISEKIRDMEKKNEHSLDIFEGHHHILQLFDYFETADNIVLITQLCQKGDLYEKIVENQCLDLETQVTSYCACLVSVLEFLHSQGIVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVLADFGLAAEYNTSKVNSLKEFVGTISYIAPEIVKCKGVGEMTPDQVGKLDKYGCPVDIWALGVLTYFMAFGYTPFDCTTDDETLECISKCDYYVDEQMMHDPKYEQFWNFVQCCFTIDPAVRRSAKNLKQHPFIKDYFATSNSLNTKDTPNFSFHPTIRRVSSTASMHTLRSPSKSRKTTTLAYLNMDGGSSETSTAFSSKMDLPDLYVDRTINSRERSLNRIRDTLKKTLSMTSLKPAGTFDYLHANKNGTSLSSSKSGLVKKNSTFVLDPKPPKNSLMNGCFSTTPESRSNFNTPKTLSRQGSSTSVKKYVNEVDLLLTPRTASMSSNDTTAINDYDTTNDKNPARKHAASFQVNVDDSDGDETMQI
Protein: NADH:FAD oxidoreductase (EC 1.5.1.37) (Chlorophenol-4-monooxygenase component 1) (Two component enzyme C) (O87008)
Organism: Burkholderia cepacia (Pseudomonas cepacia)
Function: Reductase component of a two-component system that degrades 2,4,5-trichlorophenol. TftC provides the FADH(2) required by TftD. TftD oxidizes 2,4,5-trichlorophenol (2,4,5-TCP) to 2,5-dichloro-p-benzoquinone, which is chemically reduced to 2,5-dichloro-p-hydroquinone (2,5-DiCHQ). Then, TftD oxidizes the latter to 5-chloro-2-hydroxy-p-benzoquinone.
Interaction partners:
Sequence:
MHAGEAVQQLKKAFETVASFDFRDALSKASTPVTVVATNGPFGLAGLTCSAVCSVCDRPPTVLLCINRKSYAAGIIKSNGVLSVNWLAAGQAVISQTFAGVGSVPMEERFADKGWQTIATGAPYRMDAAVSFDCTIANIVDVGSHSVIFAEVVARNHAEECTPLIYHRRQYATTRSLAE
Protein: Sodium-dependent organic anion transporter (SOAT) (Solute carrier family 10 member 6) (SLC10A6) (Q3KNW5)
Organism: Homo sapiens (Human)
Function: Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis. Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids. May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium. Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes.
Subcellular location: Membrane {ECO:0000269|PubMed:23667501}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sodium/bile acid cotransporter 7
Sequence:
MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVMMGLLMFSLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAIAVLIMGCCPGGTISNIFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLYTWSWSLQQNLTIPYQNIGITLVCLTIPVAFGVYVNYRWPKQSKIILKIGAVVGGVLLLVVAVAGVVLAKGSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRCRTISLETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRRLKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGPMDCHRALEPVGHITSCE
Protein: Interferon regulatory factor 5 (IRF-5) (P56477)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15665823, ECO:0000269|PubMed:18824541, ECO:0000269|PubMed:25326420}. Nucleus {ECO:0000269|PubMed:15665823, ECO:0000269|PubMed:18824541, ECO:0000269|PubMed:25326420}. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269|PubMed:15665823, ECO:0000269|PubMed:25326420}.
Interaction partners:
- TNF receptor-associated factor 6
- Myeloid differentiation primary response protein MyD88
- C-C motif chemokine 4
- Interleukin-1 receptor-associated kinase 1
- Toll-like receptor 7
- Interferon regulatory factor 8
- Interferon-induced helicase C domain-containing protein 1
- Interleukin-10
- Toll-like receptor 8
- Interleukin-1 receptor-associated kinase 4
Sequence:
MNHSAPGIPPPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFYIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFQLFYDGPRDMPPQPYKIYEVCSNGPAPTESQPTDDYVLGEEEEEEEEELQRMLPGLSITEPALPGPPNAPYSLPKEDTKWPPALQPPVGLGPPVPDPNLLAPPSGNPAGFRQLLPEVLEPGPLASSQPPTEPLLPDLLISPHMLPLTDLEIKFQYRGRAPRTLTISNPQGCRLFYSQLEATQEQVELFGPVTLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCALAHGSCPNPIQREVKTKLFSLEQFLNELILFQKGQTNTPPPFEIFFCFGEEWPDVKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDHMVEQFKELHHLWQSQQQLQPMVQAPPVAGLDASQGPWPMHPVGMQ
Protein: N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] (P30919)
Organism: Rattus norvegicus (Rat)
Function: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
Subcellular location: Lysosome.
Interaction partners:
Sequence:
MARKWNLPFLLLPLVLGIPLVRGSNPLPLVVNTWPFKNATEAAWWTLVSGGSALDAVEKGCAMCEKEQCGGTVGFGGSPDEVGETTLDAMIMDGTAMDVGAVGGLRRIKNAIGVARKVLEHTTHTLLVGDSATKFAVSMGFTSEDLSTNTSRALHSDWLSRNCQPNYWRNVIPDPSKYCGPYKPPDFLEQNNRAHKEVDIHSHDTIGMVVIHKTGHTAAGTSTNGLKFKIPGRVGDSPIPGAGAYADDMAGAAAATGDGDTLLRFLPSYQAVEYMRGGDDPARACQKVISRIQKYYPKFFGAVICANVTGSYGAACNRLPTFTQFSFMVYNSLHNQAIEEKVDCM
Protein: Copine-E (Q54FY7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- UBC core domain-containing protein
Sequence:
MSDSSIVNLSKEGDSNFSSATINLSKVDDTVNVSNATINLSKVTIDPSNQMSNPSNQGINLSKCTKVELRFKCMNLKDMDTFSKSDPQIFVYEKKGNNNNNNNSKPILIGSTEMISNNLNPVFKKTVTIDYHFERIQNLKFEVLDIDGGGKNDTIGDFSITLGNIISKPGKKVIGEIKCNGKQTGTIEIIAEEIQETGQNIILKLQGSKLDKKDLFSSDPFFKIFKSSANGNLLVYQSPVIKSNINPIYNPIIFKLEEFNGGDMFRELTFEFWDYDTIGDNDFIGSFKTTTDEILKGQVREFTLINPKKLSKSSYKNSGKIVFTDARLIAQPTFIDYLSGGCEINLMIAIDCTASNGMPSDRTSLHYNTPTHESEYARSILAVGNVLAPYDSDGKIELLGFGAERFGGVTSHCFQFGPKAEARGIEEVLSTYNKVIPTIKLSYPTNFQEIIKHAHKKSIKGVDSKNQKYTILLILTDGEITDMEETIEEIVKASSKAPLSIVIVGVGIASFELMKKLDGDENQLSDKNGVIATRDIVQFVPFKKYENDPEQLAAETLCEIPEQLIGYMKSQNYFPNMKN
Protein: Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) (Q8VCR8)
Organism: Mus musculus (Mouse)
Function: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. {ECO:0000250}.
Interaction partners:
- Calmodulin-like protein 4
- Myosin light chain 3
- Myosin regulatory light polypeptide 9
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin, light chain 12A, regulatory, non-sarcomeric
- Myosin light chain 6B
- Calmodulin-1
- Myosin light chain 4
- Calmodulin-4
- Calmodulin-like protein 3
Sequence:
MTTENGAVELGSQSLSTEQTPKAAAGDGPSASEKEPSAPATEKDLSPPNAKKDPGAPDPKNNPDPPSLKKDPAKAPGPEKKGDPVPASASSQGPSGEGDGGGGPAEGSEGPPAALPLPTATAEASIQKLDPTQAPSGNQGSGEAKAGKKAAECREAGRRGSPAFLHSPSCPAIISCSEKTLAVKPLSETTDLVFTGVSVTPDPQDPGPVKAGGTNALAEKKKEEAEKASGQAGQAKVQGDTPQRIGFQAVPSERVEVGQALCLTAREEDCFQILDDCPPPPAPFPHRIVELRTGNVNSEFSMNSKEALGGGKFGAVCTCTERATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETSHEIILFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTKDQSARMSAEQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
Protein: Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (O96004)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}.
Interaction partners:
- Forkhead box protein P4
- Homeobox protein Nkx-2.5
Sequence:
MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
Protein: A kinase (PRKA) anchor protein (Yotiao) 9, isoform CRA_c (AKAP9 protein) (Q6PJH3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMVCLF
Protein: Putative symporter YfeH (P39836)
Organism: Escherichia coli (strain K12)
Interaction partners:
- 2,3-diketo-L-gulonate reductase
Sequence:
MKLFRILDPFTLTLITVVLLASFFPARGDFVPFFENLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFVLFPILGVLFAWWKPVNVDPMLYSGFLYLCILPATVQSAIAFTSMAGGNVAAAVCSASASSLLGIFLSPLLVGLVMNVHGAGGSLEQVGKIMLQLLLPFVLGHLSRPWIGDWVSRNKKWIAKTDQTSILLVVYTAFSEAVVNGIWHKVGWGSLLFIVVVSCVLLAIVIVVNVFMARRLSFNKADEITIVFCGSKKSLANGIPMANILFPTSVIGMMVLPLMIFHQIQLMVCAVLARRYKRQTEQLQAQQESSADKA
Protein: Probable esterase KAI2 (Protein DWARF-14-like) (Protein D14-like) (Protein HYPOSENSITIVE TO LIGHT) (Protein KARRIKIN INSENSITIVE 2) (Q9SZU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in seed germination and seedling development. Essential for plant responses to karrikins, a class of butenolide compounds, structurally similar to strigolactones, released from burning vegetation that stimulate seed germination and enhance seedling photomorphogenesis. KAI2 is not required for strigolactone-mediated responses, but MAX2 is necessary for responses to karrikins and strigolactones. Lacks detectable hydrolase activity against karrikin. Karrikin binding induces a conformational change.
Subcellular location: Nucleus {ECO:0000269|PubMed:20864454}. Cytoplasm, cytosol {ECO:0000269|PubMed:20864454}. Note=Weak expression in the cytosol.
Interaction partners:
- F-box protein MAX2
- Protein SUPPRESSOR OF MAX2 1
- Protein SMAX1-LIKE 2
- Protein SMAX1-LIKE 7
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Protein SMAX1-LIKE 6
- F-box/kelch-repeat protein SKIP25
- Protein SMAX1-LIKE 8
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Cytochrome P450 711A1
Sequence:
MGVVEEAHNVKVIGSGEATIVLGHGFGTDQSVWKHLVPHLVDDYRVVLYDNMGAGTTNPDYFDFDRYSNLEGYSFDLIAILEDLKIESCIFVGHSVSAMIGVLASLNRPDLFSKIVMISASPRYVNDVDYQGGFEQEDLNQLFEAIRSNYKAWCLGFAPLAVGGDMDSIAVQEFSRTLFNMRPDIALSVGQTIFQSDMRQILPFVTVPCHILQSVKDLAVPVVVSEYLHANLGCESVVEVIPSDGHLPQLSSPDSVIPVILRHIRNDIAM
Protein: MIP18 family-like domain-containing protein (Q57YF8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog
- MMS19 nucleotide excision repair protein
- MMS19 nucleotide excision repair protein
Sequence:
MEELVNPNPTVFRGNLGKRKRTVEQEKEELCEDVRDPIDGLEIYELIRTIRDPEHPNTLEELQVVDPKLISVDEERQTVRVQFTPTVPHCSLTTLIGLCIGLKLKRCLPRNMKVDICVTPGSHEQEEQVNKQLGDKERVAAALENTNLLNVVESCVNAFE
Protein: Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) (Protein cinnabar) (A1Z746)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03018}. Membrane {ECO:0000255|HAMAP-Rule:MF_03018}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018}.
Interaction partners:
- Kynurenine formamidase
- FI04487p
- Tryptophan 2,3-dioxygenase
- Hydroxymethylglutaryl-CoA synthase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Nicotinate phosphoribosyltransferase
- isopentenyl-diphosphate Delta-isomerase
- Homogentisate 1,2-dioxygenase
- Glutamine-dependent NAD
- Nicotinamide-nucleotide adenylyltransferase
Sequence:
MSPGIVSQEVNGRQEPTEAARDERHGRRRRVAVIGAGLVGSLAALNFARMGNHVDLYEYREDIRQALVVQGRSINLALSQRGRKALAAVGLEQEVLATAIPMRGRMLHDVRGNSSVVLYDPINNQCLYSVGRRQLNEVLLNACDKLPNIRCHFEHKLTSANLREGSMEFRNPAKEAVAAHADLIVGCDGAFSSVRQNNVRLPGFNYSQEYIETGYLELCIPSKSGDFQMPANYLHIWPRNTFMMIALPNQDKSFTVTLSMPFEIFAGIQNQNDLLEFFKLNFRDALPLIGEQQLIKDFFKTRPQFLVSIKCRPYHYADKALILGDAAHAMVPYYGQGMNAGMEDVTLLTDILAKQLPLDETLALFTESRWQDAFAICDLAMYNYVEMRDLTKRWTFRLRKWLDTLLFRLFPGWIPLYNSVSFSSMPYRQCIANRKWQDQLLKRIFGATFLAAIVTGGAIYAQRFL
Protein: Kinesin-like protein KIN-7F (Q7X7H4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Binds ATP/ADP in vitro. Possesses low ATPase activity but high affinity for microtubules.
Interaction partners:
- Kinesin-like protein KIN-10A
- Kinesin-like protein KIN-5C
- Kinesin-like protein KIN-5A
- Kinesin-like protein KIN-5B
- Mitotic spindle checkpoint protein MAD2
- Kinesin-like protein KIN-13B
- Kinesin-like protein KIN-13A
- non-specific serine/threonine protein kinase
- Os01g0259400 protein.
Sequence:
MGAIGGDEVVQWDKMDGGEVVNGGGGGGVGKLERILVSVRLRPLSDKEIARGDPSEWECINDTTIISRSTFPDRPSAPTAYSFDRVFRSDCDTNEVYKQGAKEVALSVVSGINSSIFAYGQTSSGKTYTMTGITEYTVADIYDYIGKHEERAFVLKFSAIEIYNEVVRDLLSAENTPLRLWDDAEKGTYVENLTEVVLRDWNHLKELISVCEAQRKTGETYLNENSSRSHQILKLTIESSAREFLGKDKSTTLVASVNFVDLAGSERASQALSAGARLKEGCHINRSLLTLGTVIRKLSKVRNGHIPYRDSKLTRILQPSLGGNARTAIICTMSPARSHMEQSRNTLLFASCAKEVVTNAQVNVVMSDKALVKQLQKELARLESELRCPASYSSLESLVKEKDNQIRKMEKEIKELKLQRDLAQSRLQDLLQVVGDNHVHVSKQSSVSGRNFTFDVPQTCEDEQSTTESSEVVDSVQNFRFQGRRVAQREHKPQQAENNVQFTTPSRYSVSSPPFSGMLPTNRSDHLSQISNEDSDDICKEVRCIETNETGGNECLESSAVGSNSLQDPNAGSSMHINNDSNSSMNSRLRDESPVTLEQHLENVRKPFANIVKDLGSSTRNSSSSKVLGRSRSCRSLTGSSLFEDLEKDDCTPPNRSFIDFAGRPQNCQRRGSALNYDAESETLSRAGSMLSEITTTRDGLKANSSVAGDTEFTGIGEFVAELKEMAQVQYQKQLGHSGNGDLAEGTIRSVGLDPITDALQSPSRWPLEFEKKQQEIIDFWHACNVSLVHRTYFFLLFKGDPADSIYMEVELRRLSFLKDTYSNGAIASIPNTSLVSSAKKLQREREMLCRQMQRRLSIEERESMYTKWGVSLASKRRRLQVARCLWTETKDLEHVRESASLVARLIGLLEPGKALREMFGLSFAPQQFTRRSYNSWRYGRSSLN
Protein: Undecaprenyl diphosphate synthase (Q8THV9)
Organism: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Interaction partners:
- Bifunctional short chain isoprenyl diphosphate synthase
- Polyprenyl synthetase
- Di-trans-poly-cis-decaprenylcistransferase
- DUF5817 domain-containing protein
Sequence:
MDLLSFGHPLYERFLAWQITRSTTKTPAHVAIILKETDLLEPKGMEKLLSALLIFKRYNVELVSIYVDILKAEQPLKTELASTLGTSIEEIFTCLSSETGYKIHGLEGEVKSSRQGKDFFVYVSLGFGGRGEITRAVLSILEEVKTGSVSPEEVDEKMLESHLLVKHEPDIMIRSGGQKLSDFLVWQSVYSELYFTDVNWKDVRRIDLLRVIRDFQKRQRRYGK
Protein: Peptidase S1 domain-containing protein (Q586C6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTTASVSQSCFPIMSFLHVPGKMSQPLWLMMGTAFLVNVSRRTGTAACPFGSADASDGVDSSAHKRRRFLLTAKHTFVPWQFTDPQRLKVPEEYRRTRFVIGRLYIPDSEGKAVASLSVDLKLVAMHPTADVAVLVAKVPTSVASDAAGTASRSAVSERFDAHAELERRANAVGGGLTLAPEDPQKGSVCSIAGYRGTGLLGKLDTFDPDLLDRLSETERGQLLSSLRCVEGQQEAAVARVKIFHSKGMCRAEEGSCFHGMSGAPVLTDEKTCGGVLYGKHPDDANSVGYVPVRSFDGFVWDSVIGK
Protein: Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) (Q6GYQ0)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to the nucleus, when associated with TCF3/E12. {ECO:0000250}.
Interaction partners:
- Ral GTPase-activating protein subunit beta
- NF-kappa-B inhibitor-interacting Ras-like protein 2
- Alpha-2-macroglobulin receptor-associated protein
Sequence:
MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTIEASLKQKGHKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKIRREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQSEHGPRTLDNLINPPLNLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSFLFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFIKARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDRTTEPEQSHSNTSTLTEREPSSSSLCSIDEEHLTDIEIVRRVFSSKRSNVNFVTEIFRQAFLLPICEAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGEKREEENGTNTADHVRNSSWAKNGSYQGALHNASEEATEQNIRAGTQAVLQVFIINSSNIFLLEPANEIKNLLDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVLKMPSQAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATEWSLTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWSRDQPGQAPMRQRSATTTGSPGTEKARSIVRQKTVDIDDAQILPRSTRVRHFSQSEETGNEVFGALNEEQPLPRSSSTSDILEPFTVERAKVNKEDMSQKLPPLNSDIGGSSANVPDLMDEFIAERLRSGNASTMTRRGSSPGSLEIPKDLPDILNKQNQMRPIDDPGVPSEWTSPASAGSSDLISSDSHSDSFSAFQYDGRKFDNFGFGTDTGVTSSADVDSGSGHHQSAEEQEVASLTTLHIDSETSSLNQQAFSAEVATITGSESASPVHSPLGSRSQTPSPSTLNIDHMEQKDLQLDEKLHHSVLQTPDDLEISEFPSECCSVMAGGTLTGWHADVATVMWRRMLGILGDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNLTSPSPPVLIPPLRILTPWLFKATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHIDQDIVNTIIKHCSPQFFSLGLPGATMLIMDFIVAAGRVASSAFLNAPRVEAQVLLGSLVCFPNLYCELPSLHPNIPDVAVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEELVHESHHPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYVPRLQIYQPDSPLKIIQILIATITHLLPSTEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPFHATGAESDKTEKSVLNCIYKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHLESLKEPEPLHSPDSERSSKLQPVTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHDNHYSESTELSPELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANSNVRIIVRDLSGKYSWDSAILYGPPPVSGLSEPTSFMLSLSHQEKPEEPPTSNECLEDITVKDGLSLQFKRFRETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPVCISEKQENDVINAILKQHTEEKEFVEKHFNDLNMKAVEQDEPIPQKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLFDGAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFEDFAAQVFSPAPYHHLPSDADH
Protein: Agamous-like MADS-box protein AGL61 (Protein DIANA) (Q4PSU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor. Controls central cell differentiation during female gametophyte development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:18599653}. Note=The transport to the nucleus is dependent on dimerization with AGL80.
Interaction partners:
- Agamous-like MADS-box protein AGL80
- MADS-box transcription factor PHERES 1
- AGAMOUS-like 96
- Agamous-like MADS-box protein AGL90
- Agamous-like MADS-box protein AGL36
- Phosphate transporter PHO1 homolog 4
- MADS-box transcription factor PHERES 2
- Agamous-like MADS-box protein AGL92
- AGAMOUS-like-34
- Probable WRKY transcription factor 10
Sequence:
MYVTKYKNKLPTLQVDLIIMPHQTQACIYKQTLSLHQIFQQRKATKTLHTKKTMMSKKKESIGRQKIPMVKIKKESHRQVTFSKRRAGLFKKASELCTLCGAEIGIIVFSPAKKPFSFGHPSVESVLDRYVSRNNMSLAQSQQLQGSPAASCELNMQLTHILSEVEEEKKKGQAMEEMRKESVRRSMINWWEKPVEEMNMVQLQEMKYALEELRKTVVTNMASFNEAKDDVFGFLDNKVTVPPYVNMPSGPSNIYNFANGNGCF
Protein: Biogenesis of lysosome-related organelles complex 1 subunit BLI1 (BLOC-1 subunit BLI1) (BLOC-1 interactor 1) (P35727)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
Subcellular location: Endosome {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit SNN1
- Biogenesis of lysosome-related organelles complex 1 subunit KXD1
- Biogenesis of lysosome-related organelles complex 1 subunit CNL1
- Biogenesis of lysosome-related organelles complex 1 subunit VAB2
- Biogenesis of lysosome-related organelles complex 1 subunit BLS1
- GTPase-activating protein GYP3
Sequence:
MGEQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFKLKDDVELDDVENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSRTPK
Protein: ABC transporter G family member 29 (ABC transporter ABCG.29) (AtABCG29) (Pleiotropic drug resistance protein 1) (Q94A18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be a general defense protein.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Cytochrome P450 711A1
- ABC transporter B family member 11
- ABC transporter B family member 1
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Carotenoid cleavage dioxygenase 7, chloroplastic
- F-box protein MAX2
- Protein RADIALIS-like 2
- Dynamin-like protein ARC5
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Probable esterase KAI2
Sequence:
METLSRSLSKSLGELLASNSNNHFSRRSGSTIDDHDEEALKWAALEKLPTFARLRTTIIHPHEDLVDVTKLGVDDRQKFIDSIFKVTEEDNEKFLKKFRNRIDRVRIKLPTVEVRFEKVTIEANCHIGKRALPTLPNAALNIAERGLRLLGFNFTKTTKVTILRDVSGIIKPSRMTLLLGPPSSGKTTLLLALAGKLDQSLKVTGRVTYNGHGLEEFVPQKTSAYISQNDVHVGVMTVQETLDFSARCQGVGTRYDLLSELVRREKDAGILPEPEVDLFMKSIAAGNVKSSLITDYTLRILGLDICKDTVVGDEMIRGISGGQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTYQIVKCLQEIVRFTDATVLMSLLQPAPETFELFDDIILLSEGQIVYQGPRDHVLTFFETCGFKCPDRKGTADFLQEVTSRKDQEQYWADSKKPYSYISVSEFSKRFRTFHVGANLEKDLSVPYDRFKSHPASLVFKKHSVPKSQLFKVCWDRELLLMKRNAFFYITKTVQIIIMALIASTVYLRTEMGTKNESDGAVYIGALMFSMIVNMFNGFAELALMIQRLPVFYKQRDLLFHPPWTFSLPTFLLGIPISIFESVVWVTITYYMIGFAPELSRFLKHLLVIFLTQQMAGGIFRFIAATCRSMILANTGGALVILLLFLLGGFIVPRGEIPKWWKWAYWVSPMAYTYDALTVNEMLAPRWINQPSSDNSTSLGLAVLEIFDIFTDPNWYWIGVGGILGFTVLFNILVTLALTFLNPLEKQQAVVSKENTEENRAENGSKSKSIDVKRGMVLPFTPLTMSFDNVNYYVDMPKEMKEQGVSKDKLQLLKEVTGVFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIEGDIRISGFPKRQETFARISGYCEQNDIHSPQVTVKESLIYSAFLRLPKEVTKYEKMRFVDEVMELVELESLKDAVVGLPGITGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELLLLKRGGQVIYAGPLGQNSHKIIEYFQAIHGVPKIKEKYNPATWMLEVSSMAAEAKLEIDFAEHYKTSSLYQQNKNLVKELSTPPQGASDLYFSTRFSQSLLGQFKSCLWKQWITYWRTPDYNLARFFFTLAAAVMLGSIFWKVGTKRENANDLTKVIGAMYAAVLFVGVNNSSSVQPLIAVERSVFYRERAAEMYSALPYALAQVVCEIPYVLIQTTYYTLIIYAMMCFEWTLAKFFWFYFVSFMSFLYFTYYGMMTVALTPNQQVAAVFAGAFYGLFNLFSGFVIPRPRIPKWWIWYYWICPVAWTVYGLIVSQYGDVEDTIKVPGMANDPTIKWYIENHYGYDADFMIPIATVLVGFTLFFAFMFAFGIRTLNFQQR