wanglab/gogpt-training-data huggingface dataset:
Protein: Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (ERR ligand 1) (Q8VHJ7)
Organism: Mus musculus (Mouse)
Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear respiratory factor 1
- Sterol regulatory element-binding protein 1
- Steroid hormone receptor ERR1
- Carbohydrate-responsive element-binding protein
- Peroxisome proliferator-activated receptor gamma
- MLX-interacting protein
- Max-like protein X
- Peroxisome proliferator-activated receptor alpha
- High affinity cationic amino acid transporter 1
- Histone-lysine N-methyltransferase PRDM16
Sequence:
MAGNDCGALLDEELSSFFLNYLSDTQGGDSGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSELFQIDSENEALLAALTKTLDDIPEDDVGLAAFPELDEGDTPSCTPASPAPLSAPPSPTLERLLSPASDVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPTLRAQSRPCTELHKHLTSVLPCPRVKACSPTPHPSPRLLSKEEEEEVGEDCPSPWPTPASPQDSLAQDTASPDSAQPPEEDVRAMVQLIRYMHTYCLPQRKLPQRAPEPIPQACSSLSRQVQPRSRHPPKAFWTEFSILRELLAQDILCDVSKPYRLAIPVYASLTPQSRPRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPTRQKREEDEEEEEEEEEEEEEKEEEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLDTETHNLEEDLGSLTDSSQGRQLPQGSQIPALESPCESGCGDTDEDPSCPQPTSRDSSRCLMLALSQSDSLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKPDTKLSPGQDTAPSLPSPEALPLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVLRPEAALQRKVLRSWEPIGVHLEDLAQQGAPLPTETKAPRREANQNCDPTHKDSMQLRDHEIRASLTKHFGLLETALEGEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRRESRGPCSDGTPSVRHARKRREKAIGEGRVVYIRNLSSDMSSRELKKRFEVFGEIVECQVLTRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH
Protein: Uncharacterized protein (Q57Z79)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLPITRRGVLFSTPLLRQKFIPTQKLHSPEEEQEVKPRPHARREVWEFTPTPEHKSLVLLLYRNIIKGLMDFKSVRRRSLIAYCRFAFRRRATATEKLLIDECIEEARRAIYVLEKHHNFTRTHTYEYDSMGIPRDTGQDVATYMEEVYDPELSRQQFQHFQDVQPGREYLHQQRGLGPTSGRHHWQQQRSSAEYRVEIREEDKAMRPPPPPSGEE
Protein: Homoserine O-acetyltransferase (HAT) (EC 2.3.1.31) (Homoserine transacetylase) (HTA) (P9WJY9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00296}.
Interaction partners:
- Probable O-acetylhomoserine sulfhydrylase MetC
- Uncharacterized methyltransferase Rv3342
- O-succinylhomoserine sulfhydrylase
- Cystathionine gamma-synthase
- Homoserine dehydrogenase
- L-threonine dehydratase biosynthetic IlvA
- Probable cystathionine beta-synthase Rv1077
- Serine hydroxymethyltransferase 1
- Serine hydroxymethyltransferase 2
- Methionine synthase
Sequence:
MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR
Protein: Nucleobase-ascorbate transporter 5 (AtNAT5) (Q8RWE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative purine permease 12
- Purine-uracil permease NCS1
- Adenine/guanine permease AZG1
- Adenine/guanine permease AZG2
- Allantoinase
Sequence:
MSAPKSGGDPLPHPPKEQLPDISYCITSPPPWPEAVLLGFQHYLVMLGTTVLIPSALVPQMGGRNEEKAKLIQTILFVAGLNTLLQTVFGTRLPAVIGASYTFVPVTISIMLSGRFNDVADPVERFKRIIRATQGALIVASTLQIILGFSGLWRNVVRFLSPLSAAPLVGLVGYGLYELGFPGVAKCIEIGLPGLIILILISQYMPHVIKGGKHVFARFAVIFSVAIVWLYAFFLTLGGAYNGVGTDTQRSCRTDRAGLISAAPWIRVPWPFQWGAPLFDAGEAFAMMMASFVALVESTGAFIAVSRYASATMPPPSVISRGVGWQGVAILISGLFGTGIGSSVSVENAGLLALTKIGSRRVVQISAGFMIFFSILGKFGAVFASIPSPIIAALYCLFFAYVGAGGLSLLQFCNLNSFRTLFILGFSIFLGLSIPQYFNEHTAIKGYGPVHTGARWFNDMVNVPFSSKAFVGGCVAYLLDTTLHKKDGSIRKDRGKHWWDRFWTFKNDPRTEEFYALPFNLNKYFPSV
Protein: RNA polymerase III RPC4 (Q38DU8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPPKVPNLKFKPRHIVRAKEEPDVSESPTALDNLSFVQLERLRLQQEAALQQEQKEREQQLYSAQQHVANGVSSAPSGALHNAGAATPGGSERLRGFGRVAVAAAAVRALTRDFSNLPPTSEHLPENTMSSVLEMESENPATTVYRPTPLDSNVSAEPKHEAEFSVEGDVKVPVAETGNDGIAFLKGYEKELKSSRQDNLRFDRDVLHASANALDVEADVGRRNVGELVWFQLPRFQADPPFRLSNLPPGKVGEIKVYKSGRMIMEIGGVCYDVAVEGYSAVGTEACNVVSAVTPAQQPTDMARCYQLGLLSKKLVCTPSINVDAH
Protein: Regulator of G protein signaling 3 (A0A087WUY2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLRGMYLTRNGNLQRRHTMKEAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL
Protein: SEH-associated protein 4 (P38164)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
Subcellular location: Cytoplasm. Vacuole membrane; Peripheral membrane protein.
Interaction partners:
- Vacuolar membrane-associated protein IML1
- Protein transport protein SEC13
- Nucleoporin SEH1
- Maintenance of telomere capping protein 5
- Nitrogen permease regulator 3
- Restriction of telomere capping protein 1
- Nitrogen permease regulator 2
- GTP-binding protein GTR1
- GTP-binding protein GTR2
- Protein LST7
Sequence:
MGLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKDFGSITCLDYSESEIGMIGVGEKNGYLRIFNISGQNSSSPASHAPVGLNANNETSMTNASGGKAAQAENIVGSVSNLKDTQGYPVSETNYDIRVRAKKQRCINSLGINTNGLIAMGLDRNKHDSSLQIWDMNYHDDSHETINPMFSYCTNESIVSLKFLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRLTYDIKLNPFNDWQFSTYGDDGTLAIWDRRKLSDQASLGDLNVASPLLTFEKLVGSGAASRKYMNSCFRWSCVRNNEFATLHRGDTIKRWRLGYYCDSNRDIAADDDNEMNIENLFVSSVHDTNTMYDRVATFDYIPRSNNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFENTEIDEIRVNNEHEKSNLENVKTILKNLSFEDLDVSEDYFPSGHDEPNNEIEYSELSEEENEGSNDVLDSKRGFELFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKNLQNNAYIRNTWRWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGINGISNQDRYRQETILSDKQLNKEMEKIIKLRRKNRDRNSPIANAAGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNGHYEKAAAWAVFFGDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMSSELDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLDRTSSTVIENGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSPRYFRDQRVDEWIQTYRDMLKSWELFSMRARFDVLRSKLSRTKTGVLTADIKPRQIYIQCQNCKQNINTPRTSSPSSAVSTSAGNYKNGEAYRRNNADYKKFNTGSSEAQAADEKPRHKYCCPHCGSSFPRCAICLMPLGTSNLPFVINGTQSRDPMQTEDSQDGANRELVSRKLKLNEWFSFCLSCNHGMHAGHAEEWFDRHNVCPTPGCTCQCNK
Protein: Pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic (EC 1.2.4.1) (Q9C6Z3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic
- 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase 1, chloroplastic
- Dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic
- Dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic
- Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial
Sequence:
MSSIIHGAGAATTTLSTFNSVDSKKLFVAPSRTNLSVRSQRYIVAGSDASKKSFGSGLRVRHSQKLIPNAVATKEADTSASTGHELLLFEALQEGLEEEMDRDPHVCVMGEDVGHYGGSYKVTKGLADKFGDLRVLDTPICENAFTGMGIGAAMTGLRPVIEGMNMGFLLLAFNQISNNCGMLHYTSGGQFTIPVVIRGPGGVGRQLGAEHSQRLESYFQSIPGIQMVACSTPYNAKGLMKAAIRSENPVILFEHVLLYNLKEKIPDEDYVCNLEEAEMVRPGEHITILTYSRMRYHVMQAAKTLVNKGYDPEVIDIRSLKPFDLHTIGNSVKKTHRVLIVEECMRTGGIGASLTAAINENFHDYLDAPVMCLSSQDVPTPYAGTLEEWTVVQPAQIVTAVEQLCQ
Protein: FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) (O94887)
Organism: Homo sapiens (Human)
Function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
Interaction partners:
- Cell division control protein 42 homolog
- Proto-oncogene tyrosine-protein kinase Src
- Ras-related protein Rap-1A
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Ras-related protein Rap-1b
- Plexin-A1
- Plexin-A4
- Semaphorin-3A
- Ras-related C3 botulinum toxin substrate 1
- Tyrosine-protein kinase Fes/Fps
Sequence:
MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE
Protein: TEA domain family member 1 (Transcriptional enhancer factor TEF-1a) (Q7SXX3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002603}.
Interaction partners:
Sequence:
MDPSSWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREFHSKLKDHTVKNDAINRMGGISSAQIVSATAIHSRLGLAGLPRSALPGATGIWQVSTGQPGSSQDVKPFSQQNYPIQTTTAIAAYESPTALSAAVPPWHGRSIGTSKLRLVEFSAFLEHQRDPDLYNKHLFVHIGQTNYSYSDALLETVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQEDSGSFYGVTSQYESSENMTITCSTKVCSFGKQVVEKVETEYARFENGRFVYKISRSPMCEYMINFIHKLKHLPEKYMMDSVLENFTILLVVSNRETQETLLCMACVFEVSNSEHGAQHHIYRLVKD
Protein: DEAD-box helicase 3 X-linked (A0A087WVZ1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGSSRSQEEMKGTISSPVQKVV
Protein: Krueppel-like factor 7 (Ubiquitous krueppel-like factor) (O75840)
Organism: Homo sapiens (Human)
Function: Transcriptional factor. Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation. Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin.
Subcellular location: Nucleus {ECO:0000269|PubMed:9774444}.
Interaction partners:
- F-box only protein 38
Sequence:
MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEAAICEKSSAVDILLSRDKLLSETCLSLQPASSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGGVATAAAAVTAAGAVKSGQSDSDQGGLGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI
Protein: Guanine nucleotide-binding protein subunit beta (P36408)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14517243, ECO:0000269|PubMed:16135826}. Cell membrane {ECO:0000269|PubMed:10669414, ECO:0000269|PubMed:11598203, ECO:0000269|PubMed:14517243, ECO:0000269|PubMed:16135826}. Note=Membrane-associated protein is concentrated at the anterior of polarized cells. {ECO:0000269|PubMed:10669414}.
Interaction partners:
- Latrophilin receptor-like protein A
- Guanine nucleotide-binding protein alpha-2 subunit
- Guanine nucleotide-binding protein alpha-4 subunit
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein alpha-1 subunit
- Guanine nucleotide-binding protein-like alpha-10 subunit
- Guanine nucleotide-binding protein alpha-8 subunit
- Guanine nucleotide-binding protein alpha-6 subunit
- Small ribosomal subunit protein eS30
- Actin-related protein 2/3 complex subunit 2
Sequence:
MSSDISEKIQQARRDAESMKEQIRANRDVMNDTTLKTFTRDLPGLPKMEGKIKVRRNLKGHLAKIYAMHWAEDNVHLVSASQDGKLLVWDGLTTNKVHAIPLRSSWVMTCAYSPTANFVACGGLDNICSIYNLRSREQPIRVCRELNSHTGYLSCCRFLNDRQIVTSSGDMTCILWDVENGTKITEFSDHNGDVMSVSVSPDKNYFISGACDATAKLWDLRSGKCVQTFTGHEADINAVQYFPNGLSFGTGSDDASCRLFDIRADRELMQYTHDNILCGITSVGFSFSGRFLFAGYDDFTCNVWDTLKGERVLSLTGHGNRVSCLGVPTDGMALCTGSWDSLLKIWA
Protein: Carboxypeptidase O (CPO) (EC 3.4.17.-) (Q8IVL8)
Organism: Homo sapiens (Human)
Function: Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:21921028}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21921028}.
Interaction partners:
Sequence:
MKPLLETLYLLGMLVPGGLGYDRSLAQHRQEIVDKSVSPWSLETYSYNIYHPMGEIYEWMREISEKYKEVVTQHFLGVTYETHPMYYLKISQPSGNPKKIIWMDCGIHAREWIAPAFCQWFVKEILQNHKDNSSIRKLLRNLDFYVLPVLNIDGYIYTWTTDRLWRKSRSPHNNGTCFGTDLNRNFNASWCSIGASRNCQDQTFCGTGPVSEPETKAVASFIESKKDDILCFLTMHSYGQLILTPYGYTKNKSSNHPEMIQVGQKAANALKAKYGTNYRVGSSADILYASSGSSRDWARDIGIPFSYTFELRDSGTYGFVLPEAQIQPTCEETMEAVLSVLDDVYAKHWHSDSAGRVTSATMLLGLLVSCMSLL
Protein: Serine/threonine-protein kinase N (EC 2.7.11.13) (Protein kinase related to PKN) (A1Z7T0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17507675}. Nucleus {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Cell junction {ECO:0000250}.
Interaction partners:
- Ras-like GTP-binding protein Rho1
- 3-phosphoinositide-dependent protein kinase 1
- Ras-related protein Rac1
- RE33655p
- Taiman, isoform G
- GEO07393p1
- Cdc25-like protein phosphatase twine
- M-phase inducer phosphatase
- Estrogen-related receptor splice variant
Sequence:
MSDSYYQGEYIKHPVLYELSHKYGFTENLPESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKDRRSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAVGGLGGGNTALEGGAPATANDKVLASLEKQLQIEMKVKTGAENMIQSLGIGCDKKLLAEAHQMLADSKAKIEFLRLRIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRSRRDKDNNSSPGDLRSFVKGVTSRSSSKSYSVKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQGLLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTAPPPPPVLKATSTTPILDQEVIPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEWC
Protein: Myotubularin phosphatase domain-containing protein (Q55EE1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MNQQQIVNDQVLDNISRSQDKNVLKDFLKKGDLSTTKNSRNQTLLHLIAMNDNMVALKFYLKKKYVVFKGTNIVVDQRDKDGYTPLHCAVNQGSFEIAKKFLSRGSDPNARTESGSTPLHLLSKFCHSNKSIKLAKKLIDYGAYINHKDSKQETPLHRATMLNDNYDYLKLLLHHGANPNIVNKRGRTCQHISIEQGKVDLLELFLMYGADFNKSTSMLPSPIEMAYQSVFPSIKQFFLNRVSTRGENILMIEKAVFLGKPISNFVQNGDSFTTGTSTQLYTGKLYITNYRIVFKIDQIQNNQIASPQSSISTQTTSSSTSSPLIIIPSITVNNNQQLLLSPSPLASPSFKQQPQLQLNSSTLSTSSTGSTSSMATLVNTSNTTTPTTNNTIINNDFPLLEDEEESIPLLSILNLRTDDDKDNQTGDLDSSNNKENIIVPNSDLNFSHENIVDDCLVSSTISSSNVQNNNNNNNNSSSSSGSNSNHNSITQSASSILNTIIHFNKNIGGSLSIISHNNNNNNSPNSNNPNNNNLNNNNNNHLSTPPLSPSQSNSSFINDNQQQQKQDITMNYQLINIETKDFKQFKLYFLSLYVRDKIMELISYHYKEKIERLIKVENQNKSIQKKIAEEHIQMHDESRIQHIDRYESYGVFEESTPFLFAYLYKPIFNFSSSQSPSPSLSSSSNLSNSVISNNSFNNNQNNQNNQNNNNNFINGWEIYNQKKEYLRFNINIDENNNSNCYWRVTSINKEYKMCSSYSSSLVVLSKTLDKDLEKIFSFRSKGRIPSLSWKDPNSNASISRCSQPLVGIERSRCPEDELYCSNLALSAPSKTLYLIDARPKLNAYANTANGAGFENIHNYPNCKLVFMNIPNIHVIRKSLEKLTSSMRSSTRDKDHTESTDMRWWGCIEETGWISHIKSILEAATFSADLILKGNSILVHCSDGWDRTPQITSLTQILLDPYYRTIVGFQVLIEKEWLSFGHKFSLRLGHLPGNEEERSPIFQQFLDCCFQLCSQFPLLFEFTPTLLLFISDNIHSCKYGTFLNNCEKDRVQDQVKFKTTSIWSEVHFNIHKFLNPYYNPQDIQSIKPKLYSRCLELWKACYMRVESKDFWMHSNWLLHNSTFNFQNNQNNQNNNNTKNNLSKLFLQNQHQHKNQQQQNSDSTRASISSISSSNSYNNDTTPAHWIPQNKHSQTQHSPILASHRPTSIINDLKDI
Protein: Transmembrane protein (Q57W00)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLYDVVELLANYVQYINLTVLIAPSVFPPAYSSFLRFVGRAMNAISHGGGVAVTVNGTSKHNNTTRMFEGSTLNLPKWMPPDLRRVFALTNIVAPLSLVVLFAPVLGPPQFIAFAYALCTAVFFLAGCTLLLHAQHSLEVLESGSALLKLVRAIPSDTKVAIAAASAVSVGLLAAVGLTLRLIWGKRRQAQLLEQLRHLEQAPHSVEERVAESLMNIAASHNGCVWRDGEGGMERPVEEREREETRLRCAKAELAYQEMMQRRHGETHAFSLWWALLKLLVLLGSGTAAAFLLRKSLWESTESLFCSPLIYFPVSMLLLTTFFLALSLSVGLSEGGRRWLFDAKLWFRHLFLYTLLLLVSFLYAPLIRSAIGLIPCRDVVDNNAPVACGADNKSTSVLEVDTSKWSTTEARKLMVGSNVSCDSVNFFLYASALLTSTTYATFFILLYGLVTRQALLALEHYPLEDSGSCSARSAEVVPAIGGNTAEAFHHSGNFFGRKWEPARGTVPREGVSQSGRERMRHKNYYGRVHSSQNEVHFLYAPYTFSWRYFKLVVLAQKTAVVIFSAVMQEDDGLASPWTGFIASVILHLGMLVILVVCRPYSGPVEFALSLALQLMLVVLAAMGLVSSFKPAVVSRSLWSFVASCFLLVPCGAILVGGLLASRRQCRLKHRKRTKRRQRGNQVCGFLWDFLTCGLRPKPKHSGSHWFLHHNQEPRSYQIFVPALYFSLLKTELSANAGPLGAATSDRLRRVGSNHLHLRHNRVGDGFNSRAASPSPPAVDHSVPPANSYSTCGSPSPSAPSARPVVTSTSRSRERWAHVRSALFSGRLRSCSPAKTLFSIRQTPVTSSTWREETSEHGGVTTPQTLEPTLSISASSSPLAEEHQLCQRAMTVLFSTVGGACRWGASPCVDVQKSNTRRRLSSVAVYERGSCPYQLISRRNPWASLEGRHCEAFLERAQAVAARQRLIDFYQNQRVHMLRKQRAVDCYINAQAAQMVRWLLIFLGISAAAAAALFLRGVLQVGERHVVVGVLPNCSA
Protein: ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30) (Q5BJS0)
Organism: Rattus norvegicus (Rat)
Function: RNA-dependent helicase (By similarity). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity). Associates with mitochondrial DNA (By similarity). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7L2E3}. Mitochondrion {ECO:0000250|UniProtKB:Q7L2E3}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q7L2E3}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. Relocalizes to stress granules upon heat stress. {ECO:0000250|UniProtKB:Q7L2E3}.
Interaction partners:
- Small ribosomal subunit protein mS39
- DNA-directed RNA polymerase
- FAST kinase domain-containing protein 2
- ATP-dependent RNA helicase SUPV3L1, mitochondrial
Sequence:
MFTLDSFRKDRTQHRQRQCKLPPPRLPPMCVNPAPGGTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPENIRPAGTGGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSSWISPELRLQSDDILPLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALPLSVQQEHGQLLALLAELLRGPCGSFDVRKTADD
Protein: Large ribosomal subunit protein eL37 (60S ribosomal protein L37) (G1.16) (P61927)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL33
- Small ribosomal subunit protein uS17
Sequence:
MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS