wanglab/gogpt-training-data huggingface dataset:
Protein: Co-chaperonin GroES (10 kDa antigen) (10 kDa chaperonin) (BCG-A heat shock protein) (Chaperonin-10) (Cpn10) (P9WPE5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00580}.
Interaction partners:
- Chaperonin GroEL 1
- Chaperonin GroEL 2
- Chaperone protein DnaK
- Protein GrpE
- Chaperone protein HtpG
- Heat-inducible transcription repressor HrcA
- Chaperone protein ClpB
- ATP-dependent Clp protease proteolytic subunit 1
- Chaperone protein DnaJ 1
- ATP-dependent Clp protease proteolytic subunit 2
Sequence:
MAKVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVVAVGPGRWDEDGEKRIPLDVAEGDTVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9VSV3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Palmitoyltransferase
- Palmitoyltransferase
Sequence:
MCIKLKDDLRRFIHWGPITLLTLTLIVTWTVIHMNSMWWAPGSSLESVLNYALIWIQTFGTLYNFIRSLMVGPGFVPLKWHPQLTKDKMFLQFCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINTCVGWSNQDSFVYFLLFFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRHMATVHLTQTNLLACVFSLGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRRNAYPRKGIKPFVYPYNLGWKTNMREVFFSTGDGISWPVLPDCNEYSLTCEQLQQKKDKRARTRVFRCIRPATGHWVPIFSQGLWVSLQIPCTDDPRIALKPDDIIHVTRIQEYWLYGEIMISEKQKEKIRARKGAIRGWFPSCCAIEICEDSDSENDLAGGEPVKEQDTAAIESVETDQEIIDFMRDFSCNDGKKAKRLHIE
Protein: TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6) (Q6IWL4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y4K3}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9Y4K3}. Nucleus {ECO:0000250|UniProtKB:Q9Y4K3}. Lipid droplet {ECO:0000250|UniProtKB:P70196}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor-associated kinase 1
- Mitogen-activated protein kinase kinase kinase 7.
- Interleukin-1 receptor-associated kinase 4.
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like-binding protein 3)
- Toll-interleukin 1 receptor
- Protein ref
- Ube2n protein
- Evolutionarily conserved signaling intermediate in Toll pathway
Sequence:
MACNDVDKSSFDDVCCDSGHSSCAAAMEKERESFLSPTENPSTISVSSSMPPDQQGYDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKMTRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIEVMETKPDLQAFQRPTVMRNPKGFGYVTFLHLQALRQRGFVKEDVLLVRCEVTPRFDASLRREGVQPRGPEPSI
Protein: Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) (O88280)
Organism: Rattus norvegicus (Rat)
Function: May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Roundabout guidance receptor 2
- Roundabout homolog 1
- Roundabout homolog 4
- Roundabout homolog 4
- Roundabout homolog 3
- Netrin-1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L1
Sequence:
MAPGRTGAGAAVRARLALALALASILSGPPAAACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFTGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFIQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFMDLVCPEKCRCEGTIVDCSNQKLSRIPSHLPEYTTDLRLNDNDIAVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAAGVQELMLTGNQLETMHGRMFRGLSGLKTLMLRSNLISCVNNDTFAGLSSVRLLSLYDNRITTISPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCEGNEENSCQLSPRCPEQCTCVETVVRCSNRGLHTLPKGMPKDVTELYLEGNHLTAVPKELSTFRQLTLIDLSNNSISMLTNHTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGINPLHCDCSLRWLSEWIKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCSQDPVEQYRCTCPYSYKGKDCTVPINTCVQNPCQHGGTCHLSESHRDGFSCSCPLGFEGQRCEINPDDCEDNDCENSATCVDGINNYACVCPPNYTGELCDEVIDYCVPEMNLCQHEAKCISLDKGFRCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDAVNGYTCICPQGFSGLFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGADRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCRHGLCRSVEKDSVVCECHPGWTGPLCDQEAQDPCLGHSCSHGTCVATGNSYVCKCAEGYEGPLCDQKNDSANACSAFKCHHGQCHISDRGEPYCLCQPGFSGNHCEQENPCLGEIVREAIRRQKDYASCATASKVPIMVCRGGCGSQCCQPIRSKRRKYVFQCTDGSSFVEEVERHLECGCRECS
Protein: T-box transcription factor 3 (A0A1D5NXF3)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MNIPMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALALPPNGAAALSLPGALAKPIMDQLVGAAETAIPFSSLGHQAAAHLRPLKTLEPEEEVEDDPKVHLEAKELWEQFHKRGTEMVITKSGRRMFPPFKVRCTGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVYDERQKKENPTSDESSNEQTAFKCFAQSSCPAVPAVGTSSLKDLCPSEGDSDADSKDDPLLEASESGKISTTTATTPAPASSGAAASDDPRDKGGSPSKSHFFPSDSATSRSRERTEKAPPDSRHSPATISSSSRGGGLSGEELKSPLRDGPKVDENRLLGKEPFAPLTVQTDSTAHLSQGHLQNLGFPPALAGQQFFNPLGSGHPLLLHPGQFAMGGAFSGMAAGMGPLLATVSGASAGGSGLDSTVMATAAAQGLSGASTAALPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAASNSVHRHPFLNAVRPRLRYSPYPLPVPLPDGSSLLTTAMPGALAATSGETKGSALASSPGAVPLDSASDLTSRSSTLSSGSVSLSPKLGADKEAATSELQNIQRLVSGLDPKQDRSRSGSP
Protein: Neurogenin 3 (O08718)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Transcription factor HES-1
- Paired box protein Pax-4
- Homeobox protein Nkx-6.1
- NK2 homeobox 2
- Pancreas/duodenum homeobox protein 1
- Pro-glucagon
- Insulin-2
- Insulin-1
- Somatostatin
- Regulatory factor X, 6
Sequence:
MAPHPLDAPTIQVSQETQQPFPGASDHEVLSSNSTPPSPTLVPRDCSEAEAGDCRGTSRKLRARRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGSPGGGSSGDWGSIYSPVSQAGSLSPTASLEEFPGLQVPSSPSCLLPGTLVFSDFL
Protein: Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) (Q6NS57)
Organism: Mus musculus (Mouse)
Function: Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (By similarity). Involved in JNK signaling pathway.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O60336}. Nucleus {ECO:0000250|UniProtKB:O60336}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:O60336}. Note=Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells. {ECO:0000250|UniProtKB:O60336}.
Interaction partners:
Sequence:
MMAGEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYSAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGEKADSTFCITSSGLLCEFSDRRLLDKWVELRTTVAHCISVTQEYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASITEASRLFSGGVNARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEIKDSHQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSNDLIKIIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGIKQQGPTSPQRASGAKQHHAPVVPPSGPALSSDSDKEGEDEGTEEEELPALPILSKSTKKELASGSSPALLRSLSHWEMSRAQETMEYLDPAPVANTGPKRRGRWAQPGVELSVRSMLDLRQIETLAPSPRGPSQDSLAVSPAGPGKHGPQGPELSCVSQNERAPRLQTSQPCSCPHIIQLLSQEEGVFAQDLEPAPIEDGIVYPEPSDSPTMDTSAFQVQAPTGGSLGRMYPGSRGSEKHSPDSACSVDYSSSRLSSPEHPNEDSESTEPLSVDGISSDLEEPAEGDEDEEEEGGTGLCGLQEGGPHTPDQEQFLKQHFETLANGTAPGGPARVLERTESQSISSRFLLQVQTSPLREPSLSSSGLALTSRPDQVSQVSGEQLKGSGATPPGAPPEMEPSSGNSGPKQVAPVLLTRRHNNLDNSWASKKMAATRPLAGLQKAQSVHSLVPQDEVPSSRPLLFQEAETQGSLGSLPQAGGCSSQPHSYQNHTTSSMAKLARSISVGENPGLATEPQAPVPIRISPFNKLALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHNETEQSGPLVSLGKAHTTVEKHSCLGEGTTHKSRTECQAYPGPNHPCAQQLPVNNLLQGPESLQPLSPEKTRNPVESSRPGVALSQDSELALSLQQCEQLVAELQGNVRQAVELYRAVTSYKTPSAEQSHITRLLRDTFSSVRQELEVLAGAVLSSPGGSPGAVGAEQTQALLEQYSELLLRAVERRMERRL
Protein: Lignostilbene-alpha,beta-dioxygenase isozyme I (LSD-I) (EC 1.13.11.43) (Q53353)
Organism: Sphingomonas paucimobilis (Pseudomonas paucimobilis)
Function: Catalyzes the cleavage of the interphenyl double bond (C alpha-C beta) of lignin-derived polyphenolic diaryl-propane type compounds (Stilbene).
Interaction partners:
Sequence:
MAHFPQTPGFSGTLRPLRIEGDILDIEIEGEVPPQLNGTFHRVHPDAQFPPRFEDDQFFNGDGMVSLFRFHDGKIDFRQRYAQTDKWKVERKAGKSLFGAYRNPLTDDASVQGMIRGTANTNVMVHAGKLYAMKEDSPCLIMDPLTLETEGYTNFDGKLQSQTFCAHPKIDPVTGNLCAFAYGAKGLMTLDMAYIEISPTGKLLKEIPFQNPYYCMMHDFGVTEDYAVFAVMPLLSSWDRLEQRLPFFGFDTTLPCYLGILPRNGDARDLRWFKTGNCFVGHVMNAFNDGTKVHIDMPVSRNNSFPFFDVHGAPFDPVAGQGFLTRWTVDMASNGDSFEKTERLFDRPDEFPRIDERYATRAYRHGWMLILDTEKPYEAPGGAFYALTNTLGHIDLATGKSSSWWAGPRCAIQEPCFIPRSPDAPEGDGYVIALVDDHVANYSDLAIFDAQHVDQGPIARAKLPVRIRQGLHGNWADASRLAVAA
Protein: NTF2 domain-containing protein (Q38C20)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSITQSALGREWGVVACGFLVTYYREFTKEGEPLALLDMYADNSHVVYAEYNENVAQIVRGRHEILQHLEKMDAALGRRKVEVRFADFSPIAGGSVLIVTQGIMYVRGSRKVFTQSFVLAPTPNRSNTYHIASEYFRVLHVEMERIPEGSIIMTPVQVAQHLLGEQERRKREEEAREHFLFLQKQKEEQQQQQQQMLQCADAEMVKQQENDRALAAENQSEAWDKHPRGQDRRMGRKDYRNRAPAGARSEGVEERKERAEWEMGKPTESRTNEAEDDTAGEGNERNRWEQPRRSEPHKRPERVKRNEGGRRAEGNDQNEVGRPERKDRRDAEREPRDGESRRGHWGRNEEKVDNVDTADNTRVTEGDAARSTGAAGAASERTRRNTFNNRPRDRFRNRELQQEQQPAAPADSAAAVPATSSAADNKGDAGRNDHKPLPRSEANRRGPGGSKEAKNNKKEAWASEKNDANNGGAAPDAAAAEENVTPAEQRKKFPRSRADKKIAGEGTRLEHRKGPTDHVRLIDAPKGQNEQISAAIKRITGEEPKKVVPFGRGNDIVCQLSTESAAEALLEKPPVVNECALRVARFYP
Protein: Chloroplast processing peptidase (EC 3.4.21.89) (Signal peptidase I-3) (Q8H0W1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the maturation of the plastid protein translocation channel. Required for the biogenesis of plastid internal membranes. May also function as a thylakoidal processing peptidase.
Subcellular location: Plastid, chloroplast envelope {ECO:0000269|PubMed:16275749}. Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:16275749}. Note=May be located at the envelope membranes in premature chloroplast and at the thylakoidal membrane in mature chloroplasts.
Interaction partners:
- Probable thylakoidal processing peptidase 2, chloroplastic
- Thylakoidal processing peptidase 1, chloroplastic
- Protein TOC75-3, chloroplastic
- Cyanate hydratase
- At5g12120
- At2g26920
- Protein TIC 40, chloroplastic
- Protein TOC75-4, chloroplastic
- signal peptidase I
- Signal peptidase complex catalytic subunit SEC11
Sequence:
MMVMISLHFSTPPLAFLKSDSNSRFLKNPNPNFIQFTPKSQLLFPQRLNFNTGTNLNRRTLSCYGIKDSSETTKSAPSLDSGDGGGGDGGDDDKGEVEEKNRLFPEWLDFTSDDAQTVFVAIAVSLAFRYFIAEPRYIPSLSMYPTFDVGDRLVAEKVSYYFRKPCANDIVIFKSPPVLQEVGYTDADVFIKRIVAKEGDLVEVHNGKLMVNGVARNEKFILEPPGYEMTPIRVPENSVFVMGDNRNNSYDSHVWGPLPLKNIIGRSVFRYWPPNRVSGTVLEGGCAVDKQ
Protein: Pancreatic trypsin inhibitor (Aprotinin) (Basic protease inhibitor) (BPI) (BPTI) (P00974)
Organism: Bos taurus (Bovine)
Function: Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
Subcellular location: Secreted.
Interaction partners:
- chymotrypsin
- Chymotrypsinogen B
- CTRB1 protein
- Serine protease 1
- Anionic trypsin
- Actin, cytoplasmic 1
- Presenilin-1
- Albumin
- Lactoperoxidase
- Amyloid beta protein binding family B member 1
Sequence:
MKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGAIGPWENL
Protein: Doublecortin-like and CAM kinase-like protein (Q9VCL7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH17657p
- Echinoderm microtubule-associated protein-like CG42247
- Proteasome subunit alpha type
- AT20903p
- non-specific serine/threonine protein kinase
- 60 kDa heat shock protein homolog 1, mitochondrial
- GH07076p
- IP12902p
- AT10852p
- inositol-phosphate phosphatase
Sequence:
MSEQSTSLGSRRVGPPLHKKALRVCFLRNGDRHFKGVNLVISRAHFKDFPALLQGVTESLKRHVLLRSAIAHFRRTDGSHLTSLSCFRETDIVICCCKNEEIICVKYSINKDFQRMVDSCKRWGQHHLDSGTLESMKSHDLPEAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHLDCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFLAL
Protein: Pasiflora 1, isoform A (Pasiflora 1, isoform B) (RE54605p) (Q9VEF6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD42595p
- UPAR/Ly6 domain-containing protein cold
Sequence:
MVVLSSCWSPIIWSDNVRTGSYAVAGYTAALSAVMITLISYMLAGGESAQLYSPLFETDIRSSMPVAGGFFIIYFLLIILSSYLVYYGIKISTRGWLLPWLGLIGLAILFQFSWSLWLIGGYYIYLEQTFSALLNFVWVAYNIYCWLVVFSQYQIFLEIQNPNIELLMP
Protein: ribonuclease III (EC 3.1.26.3) (Q2Q3V8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
PRGYQLRLVDHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQQAMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVTQTYVALSSLSVVIIDECHHGTGHHPFREFMRLFTIANQTKLPRVVGLTGVLIKGNEITNVATKLKELEITYRGNIITVSDTKEMENVMLYATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVSLDLMNIGVQPIRRSKSLQCLRDPSKKSFVKQLFNDFLYQMKEYGIYAASIAIISLIVEFDIKRRQAETLSVKLMHRTALTLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSLKVSFADKDPKDICCLVFVERRYTCKCIYGLLLNYIQSTPELRNVLTPQFMVGRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADKEREKTIQQIYQYRKAHNDIAEYLKDRVLEKTEPELYEIKGHFQDDIDPFTNENGAVLLPNNALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYSDPMDNVKTAKISAAFKACKVLYSLGELNERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDRTYKTECPLEFYDALPRVGEICYAYEIFLEPQFESCEYTEHMYLNLQTPRNYAILLRNKLPRLAEMPLFSNQGKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPLILGAGEHKCFDWELMTNFRRLPQSHGSNVQQREQQPAPRPEDFEGKIVTQWYANYDKRMLVTKVHRELTPLSYMEKNQQDKTYYEFTMSKYGNRIGDVVHKDKFMIEVRDLTEQLTFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPGDLWLKLIFLPSILNRMYFLLHAEALRKRFNTYLNLHLLPFNGTDYMPRPLEIDYSLKRNVDPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELDYYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSRPTVRGKVKPLLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEGTLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKMIGPHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYAGADFSSEVNFCVGLVTIPNKVIADTLEALLGVIVKNYGLQHAFKMLEYFKICRADIDKPLTQLLNLELGGKKMRANVNTTEIDGFLINHSYLEKNLGYTFKDRRYLLQALTHPSYPTNRITGSYQELEFIGDAILDFLISAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGHRVTNYVRILLEEADVQPTPLDLDDELDMTELPHANKCISQEAEKGVPPKGEFNMSTNVDVPKALGDVLEALIAAVYLDCRDLQRTWEVIFNLFEPELQEFTRKVPINHIRQLVEHKHAKPVFSSPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQQLSKCDA
Protein: Nickel insertion protein (Q727T2)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- PP-loop domain protein
- PurE domain-containing protein
Sequence:
MRLFMDCRAGIAGDMVLAAFAGLGVDMQPLQALFVAAGVDCRIRAIPVTRHGLTGHTLSVEWDDPQPLRTLPDMAAVLDGLACTGTVRQRAWRAFTRLAEVEAAVHGVRPEDVHFHEVGAIDTLVDVVGAFWALERLGVDEVVCSALPWFSGVVVCAHGTLPLPAPAVVRLLEGVPVFPTAAREELVTPTGALVATALADRFDEGPSGIVRASATGYGSRPSGGGLRLFLHEAAPCALSGQGRYGTGHGNPTAGDVTTTGAAQKGYRVETVVQLETHLDHLTGEELGRCFDVLPQAGALDVLWLPGVMKKNRPGGVLRVLCEPRARSGVEAAIFEHTHTLGIRRQLLERVVAARGASLVEVGDEDVPAKGYEVDGVTFSRPEYDALCDLSRRTGRSLPALRMMLWGERGPTMTDSGLPQDAGDAEEDEVETAPGNVQPVR
Protein: Magnesium-dependent phosphatase 1 (D4A4U3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Programmed cell death 6-interacting protein
- Tyrosine-protein phosphatase non-receptor type 23
Sequence:
MTRLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQDIRLYPEVPEILGRLQSLGVPVAAASRTSEIEGANQLLELFDLGKYFIQREIYPGSKVTHFERLRNKTGVPFSQMIFFDDENRNIIDVGKLGTESLLRGRYLHSHTGWNESSNVNSRIRDICKSPSWTLRSGPVDKPHYSVKLKRNQGSLVRSTCNVLKCPRVTIRVLSQYGLFPFFFSFLLFFFKDLFIYYI
Protein: Emb|CAB85509.1 (Q9LZC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- HTH-type transcriptional regulator
- 6,7-dimethyl-8-ribityllumazine synthase
- D-ribose-binding periplasmic protein
- Uncharacterized protein At5g66580
- At1g71015
- At3g03280
- 6,7-dimethyl-8-ribityllumazine synthase
- Uncharacterized protein At5g17350
- Uncharacterized protein At3g50800
- HTH-type transcriptional regulator
Sequence:
MGNCLVMEKKVIKIVRDDGKVLEYREPISVHHILTQFSGHSISHNNTHLLPDAKLLSGRLYYLLPTTMTKKKVNKKVTFANPEVEGDERLLREEEDSSESNSNIDGDDTKNVTVVRMKIVVHKQELEKLLQGGSVHEMMYQTLEKQLLLTSSDDDDLECNSGWRPALDSIPESESLRRT
Protein: 2-iminoacetate synthase (EC 4.1.99.19) (Dehydroglycine synthase) (Tyrosine lyase) (P30140)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol.
Interaction partners:
- Thiazole synthase
- Thiamine-phosphate synthase
- Sulfur carrier protein ThiS adenylyltransferase
- Phosphomethylpyrimidine synthase
- Sulfur carrier protein ThiS
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
- tRNA sulfurtransferase
- Thiamine-monophosphate kinase
- Hydroxyethylthiazole kinase
- Flagellar basal body rod protein FlgB
Sequence:
MKTFSDRWRQLDWDDIRLRINGKTAADVERALNASQLTRDDMMALLSPAASGYLEQLAQRAQRLTRQRFGNTVSFYVPLYLSNLCANDCTYCGFSMSNRIKRKTLDEADIARESAAIREMGFEHLLLVTGEHQAKVGMDYFRRHLPALREQFSSLQMEVQPLAETEYAELKQLGLDGVMVYQETYHEATYARHHLKGKKQDFFWRLETPDRLGRAGIDKIGLGALIGLSDNWRVDSYMVAEHLLWLQQHYWQSRYSVSFPRLRPCTGGIEPASIMDERQLVQTICAFRLLAPEIELSLSTRESPWFRDRVIPLAINNVSAFSKTQPGGYADNHPELEQFSPHDDRRPEAVAAALTAQGLQPVWKDWDSYLGRASQRL
Protein: Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.128) (Nitrilase homolog 1) (Q8VDK1)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:19479888, ECO:0000269|PubMed:28373563}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19479888, ECO:0000269|PubMed:28373563}.
Interaction partners:
- Bis
Sequence:
MLGFITRPPHQLLCTGYRLLRTPVLCTQPRPRTMSSSTSWELPLVAVCQVTSTPNKQENFKTCAELVQEAARLGACLAFLPEAFDFIARNPAETLLLSEPLNGDLLGQYSQLARECGIWLSLGGFHERGQDWEQNQKIYNCHVLLNSKGSVVASYRKTHLCDVEIPGQGPMRESNYTKPGGTLEPPVKTPAGKVGLAICYDMRFPELSLKLAQAGAEILTYPSAFGSVTGPAHWEVLLRARAIESQCYVIAAAQCGRHHETRASYGHSMVVDPWGTVVARCSEGPGLCLARIDLHFLQQMRQHLPVFQHRRPDLYGSLGHPLS
Protein: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Nuclear receptor-binding factor 1) (NRBF-1) (Q9Z311)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity).
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12654921}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25031892}. Nucleus {ECO:0000269|PubMed:25031892}.
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Fatty acid synthase
- Trifunctional enzyme subunit alpha, mitochondrial
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Enoyl-CoA hydratase, mitochondrial
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 3
Sequence:
MLVSRRLTGARARAPLLASLLEAWCRQGRTTSSYSAFSEPSHVRALVYGNHGDPAKVIQLKNLELTAVEGSDVHVKMLAAPINPSDINMIQGNYGLLPKLPAVGGNEGVGQVIAVGSSVSGLKPGDWVIPANAGLGTWRTEAVFSEEALIGVPKDIPLQSAATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALGLKTINVIRDRPDIKKLTDRLKDLGADYVLTEEELRMPETKNIFKDLPLPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVTASVSMLIFKDLKLRGFWLSQWKKNHSPDEFKELILILCNLIRQGQLTAPAWSGIPLQDYQQALEASMKPFVSLKQILTM
Protein: 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) (F Alloantigen) (F protein) (P32755)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12867153}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12867153}; Peripheral membrane protein {ECO:0000269|PubMed:12867153}. Golgi apparatus membrane {ECO:0000269|PubMed:12867153}; Peripheral membrane protein {ECO:0000269|PubMed:12867153}.
Interaction partners:
- Homogentisate 1,2-dioxygenase
- Tyrosine aminotransferase
- Nucleolin
- Toll-like receptor 4
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Fumarylacetoacetase
- Macrophage migration inhibitory factor
- Amine oxidase
- Amine oxidase
Sequence:
MTTYSNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGRKKSQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQALRGNLTDLETNGVRSGM