wanglab/gogpt-training-data huggingface dataset:
Protein: Kis2p (Q5AKY0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 5'-AMP-activated protein kinase subunit gamma
- Carbon catabolite-derepressing protein kinase
- non-specific serine/threonine protein kinase
- Protein SDS23
- Protein phosphatase regulator
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Kis1p
Sequence:
MGNNTSTGNFHSSGSNKRQGNSSDSIRKSSASVNYNNSVDSSSDNRVRKSTANKNANSLDEEFSDLILHQVVKNSRTLEAAPLQPSPKGEPTNPHHQQSNVYSTHYNQFSDDLIEDEFNELNEGIVETEMGSLQRNIIPDQGFGNDPTNTTSSSDSTGTYNYSSTLNDDMEIDAPFPHDDDDDNDSDGVNKVFPQSRSRTPTPDLTKVDFTKIISQAPPGYDGDTNMNGSGSVPPPTQMMSAASVARNAHSPLPNSDHHQKNLQQQRQPQQQQQLQSSFPDNSCGNTHAYPQQHGRPTKILKTNQQSQQFLIPIEIKWVNTTKEAIHKIAIIGSFSNWRDVIKMYPSTSHPNEFVTTINLPLGVHKLLYIINNEYRVSDQLPTATDQEGIFFNWFEVIDDTHLFNHSLNQPNHIGASTDYDANIIRYDNTTTTTSEMSTTTTATTTTTPKYVQPQTWAPRPAGKSDVDKINQKETDLLYKMSKEASGEFEHVEFIEDTDATGNGNGATAGTAGQSQDSSTPQGHNNHEAINSVDEIAFDNNPYQNYELSTSSSSFLQTTGQIIENPVEYSSEIPEMFINYDYFKMKPADYELPEPPQLPPHLNNVLLNKMTSSSSSGSGSGSGYSSTSHGSGSMTQHLSSIGNVSTISGSLPKSQSLSSTIGSGSSSSVSNTGSYLNNKRPPLRRADSSYYASNKDAYHLSIPNHVILNHLMTTSIKNDVLTVACITRYSGKFVTQIIHSPADTK
Protein: Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b) (Q61190)
Organism: Mus musculus (Mouse)
Function: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Interleukin-10
- Interleukin-10 receptor subunit alpha
- Non-receptor tyrosine-protein kinase TYK2
- Interleukin-22
- Interleukin-22 receptor subunit alpha-1
- Interferon lambda receptor 1
- Interferon lambda-3
- Tyrosine-protein kinase JAK1
- Interferon lambda-2
- Interleukin-20 receptor subunit alpha
Sequence:
MAPCVAGWLGGFLLVPALGMIPPPEKVRMNSVNFKNILQWEVPAFPKTNLTFTAQYESYRSFQDHCKRTASTQCDFSHLSKYGDYTVRVRAELADEHSEWVNVTFCPVEDTIIGPPEMQIESLAESLHLRFSAPQIENEPETWTLKNIYDSWAYRVQYWKNGTNEKFQVVSPYDSEVLRNLEPWTTYCIQVQGFLLDQNRTGEWSEPICERTGNDEITPSWIVAIILIVSVLVVFLFLLGCFVVLWLIYKKTKHTFRSGTSLPQHLKEFLGHPHHSTFLLFSFPPPEEAEVFDKLSIISEESEGSKQSPEDNCASEPPSDPGPRELESKDEAPSPPHDDPKLLTSTSEV
Protein: Ulp1 protease family protein (AFU_orthologue AFUA_7G04610) (C8V793)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Ubiquitin-like domain-containing protein
- NEDD8-activating enzyme E1 catalytic subunit
- N-acetylglucosaminylphosphatidylinositol deacetylase
- NEDD8-activating enzyme E1 regulatory subunit
- Aconitate hydratase, hypothetical
- Homoaconitase, mitochondrial
- Aconitate hydratase, mitochondrial
- Aconitate hydratase, mitochondrial
- Zn
- Putative aconitate hydratase, mitochondrial
Sequence:
MRDGGLGKLQKRMRRFGDTLNPDDAYLSYHDIRLTRGDLQSLKDDWLTDNVRLITFLYLEREFLTEYKSSNIVLLRPSMSFMILQTPNPHSLRDALPDFTRTTHVFLPINDCRNVTEAEGGTHWSLLLISIVDGVAFHYDSLPPGNYWEAKTVTMKFGALLNRPIRFVNLDDSPTQENGSDCGVFVCLSMRHLLLKRLLRANSNEKVSMSLGGWKVDARLGRKEIAKIIEGFRKEGERRRSASLSPSGKKSRSPPRIE
Protein: Protein phosphatase EYA1 (EC 3.1.3.16) (EC 3.1.3.48) (Eyes absent homolog 1) (P97767)
Organism: Mus musculus (Mouse)
Function: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10490620}. Nucleus {ECO:0000269|PubMed:10490620, ECO:0000269|PubMed:19234442}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q99502}.
Interaction partners:
- Homeobox protein SIX1
- Homeobox protein SIX2
- T-cell leukemia homeobox protein 1
- Homeobox protein SIX4
- Dachshund homolog 1
- Paired box protein Pax-2
- Homeobox protein SIX5
- Homeobox protein SIX3
- Transcription factor SOX-2
- Sal-like protein 1
Sequence:
MEMQDLTSPHSRLSGSSESPSGPKLDSSHINSTSMTPNGTEVKTEPMSSSEIASTAADGSLDSFSGSALGSSSFSPRPAHPFSPPQIYPSKSYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGALWAGIKTESGLSQSQSPGQTGFLSYGTSFGTPQPGQAPYSYQMQGSSFTTSSGLYSGNNSLTNSSGFNSSQQDYPSYPGFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGVTSQAVTDPTAEYSTIHSPSTPIKETDSERLRRGSDGKSRGRGRRNNNPSPPPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRVSSHSDLMALHHALELEYL
Protein: Sodium channel protein (F1QXF5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
Interaction partners:
- Sodium channel regulatory subunit beta-3
- Sodium channel, voltage-gated, type I, beta b.
- Syntaxin-binding protein 1a
- Sodium channel subunit beta-2
- Syntaxin-binding protein 1
- Scn4ba protein
Sequence:
MAAQLLVPPGPDSFRPFLPESLAAIEQRIAEEVAQRPKGERRPDDDDENGPKPNRDLEAGKPLPFIYGDVPPHMLSVPLEDLDTYYSNQKTFIVLNRGKAIFRFNATPALYILSPFNPLRRISIRVLVHSLFSFVIMCTILTNCAFMTLSNPPEWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFSVILMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVKMPEVNVTDNLTDYSTELHNSTFNWTEYISDSNNYYFIPGRRDALLCGNSSDAGQCPEGFTCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLYQQTLRAAGKPYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQQKEEEFQAMLEQLKRQQEEAQVAAAAATESGEYSGRGGLSEESSSGGSRLSSKSAKERRNRRKKRKQREEEEKADQEKFHKSASEDSIRRPGFRFSIDANRLSYEKKCSTPNQSLLSIRGSLFSPRRNSRASLFSFRGRARDFGSENDFADDEHSTFEDSDSRRGSLFVPRCVERRSSTVSHCSLTAPRIMLPANGKMHCTVDCNGVVSLVGGTSVPTSPIGRLLPEGTTTESDVRKKRSGSHQPSDYLEETVARKRAMSVASILTNTMEELEESRQKCPPCWYKFANSFLIWDCSPAWLKVKEIMNMIVMDPFVDLAITICIVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTGIFTAEMCLKVIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYRECVCKISESCELPRWHMDDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDSEMNNLQIAVGRIQKGIALVKSTLRQFLQSLFLAGSKPRSLDEEKPLDDLHSDGKENCLSNHAPVAVDLTKDYLKEGCVSPGNGVESHVKYGIEEGDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESSDVEGSKEKLPVDTVLSSSEGSTVDIRPPGEGAESVELEPEESLDPEACFTEGCVMRFQCCQVDVEKGKWKSWWILRKTCFIIVEHNWFESFIIFMILLSSGALAFEDIYIEQRKTIKTVLEYADKVFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVANALGYSELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCVNITNDELFPVSVVNNKSDCYALIQNNDTARWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDLEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDIIIMILICLNMVTMMVETDDQTEDMDNILYWINLVFIILFTGECVLKMISLRHYFFTIGWNVFDFVVVILSIVGMFLSEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREAGIDDMFNFETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDCDSEMEHPGSFYRGNCGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPNATQFVEYNKLSDFADALDPPLRIAKPNKIQLIAMDLPMVSGDRIHCLDILFAFTLRVLGEEGEMDALRGQMEDRFMASNPSKVSYEPITTTLRRKQEEMSAVVIQRAFRRHRIRQTVKKASEAYRKQLQDGGGHIPEKEVLVIGKFQENSASDKTDMTPSSASPPSYNSVAKSEKDKYEKERREKEDKAKDARDRKK
Protein: Stretchin-MLCK (Q9N630)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
YTCCATNDFGESLTHAQLRVYKHFKEAPLPSTFTQPIRDTYSLNENELVLDCRVRGQPRPEIQWIKGTEPIEASEKFKPSDQADGYAKLVIVNPTEKDSGIYWCVARNEGAENKISHQVDFKGRQHYSLEKTHGFFHRDPNKPHFLLPLGNQTVCNGGTVAISAEFMETSTPIEVKWLXDRRVVDGPNVKXLADRGVYTLTIMNAGPEVEGTYTC
Protein: Glycine-rich protein 3 short isoform (Q9ZSJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the function of the receptor protein kinase WAK1.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Interaction partners:
- Copper ion binding protein
- Leucine-rich repeat
- Phosphoglycerate mutase family protein
- UDP-glycosyltransferase 76C5
- Large ribosomal subunit protein bL21m
- LIMR family protein At3g08930
- Expressed protein
- Insecticidal crystal toxin domain-containing protein
- Non-specific lipid transfer protein GPI-anchored 13
- Staphylococcal-like nuclease CAN2
Sequence:
MASKTLLLLGLFAFLFIVSEMAAAGTVKSESEETVKPEQHGGGFGDNGGGRYQGGGGHGGHGGGGYQGGGGRYQGGGGRQGGGGSYCRHGCCYKGYHGCSRCCSYAGEAVQTQSGH
Protein: DNA primase (EC 2.7.7.101) (P0ABS5)
Organism: Escherichia coli (strain K12)
Function: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Interaction partners:
- Replicative DNA helicase DnaB
- Replicative helicase loader DnaC
- Chromosomal replication initiator protein DnaA
- RNA polymerase sigma factor RpoD
- Replication restart protein DnaT
- DNA polymerase III subunit tau
- Beta sliding clamp
- DNA polymerase III subunit alpha
- Replication restart protein PriC
- Small ribosomal subunit protein bS21
Sequence:
MAGRIPRVFINDLLARTDIVDLIDARVKLKKQGKNFHACCPFHNEKTPSFTVNGEKQFYHCFGCGAHGNAIDFLMNYDKLEFVETVEELAAMHNLEVPFEAGSGPSQIERHQRQTLYQLMDGLNTFYQQSLQQPVATSARQYLEKRGLSHEVIARFAIGFAPPGWDNVLKRFGGNPENRQSLIDAGMLVTNDQGRSYDRFRERVMFPIRDKRGRVIGFGGRVLGNDTPKYLNSPETDIFHKGRQLYGLYEAQQDNAEPNRLLVVEGYMDVVALAQYGINYAVASLGTSTTADHIQLLFRATNNVICCYDGDRAGRDAAWRALETALPYMTDGRQLRFMFLPDGEDPDTLVRKEGKEAFEARMEQAMPLSAFLFNSLMPQVDLSTPDGRARLSTLALPLISQVPGETLRIYLRQELGNKLGILDDSQLERLMPKAAESGVSRPVPQLKRTTMRILIGLLVQNPELATLVPPLENLDENKLPGLGLFRELVNTCLSQPGLTTGQLLEHYRGTNNAATLEKLSMWDDIADKNIAEQTFTDSLNHMFDSLLELRQEELIARERTHGLSNEERLELWTLNQELAKK
Protein: DNA repair protein RAD51 homolog 3 (F4IW45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MISFGRRKSPAIEETSLATSVMEAWRLPLSPSIRGKLISAGYTCLSSIASVSSSDLARGKFLLYPNLRRLESVARFSLISTDNANITEEEAFEILKLANQSCCNGSRSLINGAKNAWDMLHEEESLPRITTSCSDLDNILGGGISCRDVTEIGGVPGIGKTQIGIQLSVNVQIPRECGGLGGKAIYIDTEGSFMVERALQIAEACVEDMEEYTGYMHKHFQANQVQMKPEDILENIFYFRVCSYTEQIALVNHLEKFISENKDVKVVIVDSITFHFRQDYDDLAQRTRVLSEMALKFMKLAKKFSLAVVLLNQVTTKFSEGSFQLALALGDSWSHSCTNRVILYWNGDERYAYIDKSPSLPSASASYTVTSRGLRNSSSSSKRVKMM
Protein: Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (F1QPS1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367136}; Single-pass membrane protein {ECO:0000256|RuleBase:RU367136}.
Interaction partners:
- ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.
- GDP-Man:Man
- SMAD family member 9.
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Structure-specific endonuclease subunit MUS81
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Dolichol-phosphate mannosyltransferase subunit 1
- ALG14 UDP-N-acetylglucosaminyltransferase subunit.
- Phosphomannomutase
- Helicase ATP-binding domain-containing protein.
Sequence:
MRWVMCTELGRHFGSIRKPVSLSRQLCAIFVSHSNKQTDEFVSVNVKGSCQDSMVRVVFLHPDLGIGGAERLVVDAAVALRSRGCSVQIWTAHYDPQHCFSETLSPDLPVVCVGDWLPTSVFGYFHALCAYLRMIYLTIYLVLFSGEEFDVVFCDQVSACIPFLRLARQRKKVLFYCHFPDQLLTQRRSALKRLYRGPIDWFEELTTGMADRILVNSQFTAKVFKQTFPKLSEIHTDVLYPSLNSSAFDDEVEGLGGLLPEGRSFIYLSINRYERKKNLPLALQALANLKDRLSVGEWERVHLVMAGGYDERVVENVEHYEELRSLVTSLGLEDHVTFLRSFSDKQKLSLLHNSTCVLYTPSNEHFGIVPIESMYLRCPVIAVNSGGPLESVAHEETGFLCEPTPERFSEAMQNFVSDPKLKQRMGQAGRERVQQRFSMQAFTEQLYSHIASLTQ
Protein: Ferric/cupric reductase transmembrane component 2 (EC 1.16.1.9) (Ferric-chelate reductase 2) (P36033)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8164662}; Multi-pass membrane protein {ECO:0000269|PubMed:8164662}.
Interaction partners:
- Probable ferric reductase transmembrane component 8
- Iron-regulated transcriptional activator AFT1
- Metal-binding activator 1
- Iron transport multicopper oxidase FET3
- Plasma membrane iron permease
- Ferric/cupric reductase transmembrane component 1
- Siderophore iron transporter ARN1
- Copper-transporting ATPase
- Low-affinity Fe
- Copper transport protein CTR3
Sequence:
MHWTSILSAILLFCLSGARASPAKTVIRNKVPLLVTNACTRIFQKVTWEYTSKSKRSSPVCSYEPAFQSMLYCIYETLDEKGYSNKTLEKTFSTIKKNCASYSDALQNMTNSEFYDVLNNGTRHMTPYVKGSANLTYPVEMDTQLRKAYYHALHGFYANLDVGNIYGGIICAYFVAIMAFAGVLHCMNYTPFKTVLLKQKLVGYVRGYLTLPTIGSKHASDFSYFRIFTGYLPTRLEGIIILGYLVLHTVFLAYGYEYDPENIIFKSRRVQVARYVADRSGVLAFAHFPLIVLFAGRNNFLEYISGVKYTSFIMFHKWLGRMMFLDAMIHGSAYTSYTVANKTWATSKNRLYWQFGVAALCLAGTMVFFSFAVFRKYFYEAFLFLHIVLGAMFFYACWEHVVSLSGIEWIYTAIAIWIVDRIIRIIKASYFGFPKASLQLIGDDLIRLTVKKPARPWRAKPGQYVFVSFLHPLYFWQSHPFTVLDSVSKNGELVIILKEKKGVTRLVKKYVCRNGGKTSMRLAIEGPYGSSSPVNNYNNVLLLTGGTGLPGPIAHAIKLGKTSAAAGKQSVKLVIAVRGFDVLEAYKPELMCLENLNVQLHIYNTMEVPSLTPSDSLDISQQDEKADEKGTVVATTLEKSANPLGFDGVVFHCGRPNVKELLHEAAELSGSLSVVCCGPPIFVDKVRNETAKIVLDKSAKAIEYFEEYQCW
Protein: NIPSNAP domain-containing protein (Q9D9L2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLALRGSLRRLSQALVHQVCSPFTTGHRQQEGTFYEFCTYYLKPASVEEFLYNFKKNVHLRTAHSELVGYWTVGFGGRINTVFHIWKYDNFAHRAAVYKALAKDEDWQEQFLIPNLPLIDKQESEITYLVPWCKIGKPPKEGVYELATFLMKPGGPALWGEAFQRAVNAHADQGYIKLIGVFHAEYGLLTEFMFCGGVRTQTLGQLGDGKPMKIPESCLLSGKVSTT
Protein: Alkane 1-monooxygenase 2 (EC 1.14.15.3) (Alkane hydroxylase) (AHs) (Terminal alkane hydroxylase) (Q0VTH3)
Organism: Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Function: Catalyzes the hydroxylation of n-alkanes in the presence of a NADH-rubredoxin reductase and rubredoxin. It preferably hydroxylases C8-C16 hydrocarbons.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Alkane 1-monooxygenase 1
- Aldehyde dehydrogenase family protein
- S-
- Aldehyde dehydrogenase
- Transcriptional regulator, GntR family
Sequence:
MFENTNPDVMLKMKKYGYLAFWAIMVPLVPFSAFVGVESGTQDYWAWFMYAFIFGIIPVLDYLVGKDPTNPSEDVQVPTMSEEVFYRVSAIAMGFVWIAVLFYAGHIFMNNGYGLLGKIGWIVSIGTVGGIIAINLGHELIHKDPKVENWMGGLLLSSVTYAGFKVEHVRGHHVHVSTPDDASSSRYNQSLYNFLPKAFVHNFINAWSLEKKYLERKGKKNISVHNELIWWYSISALFAATFGLLWGWQGVVFFLGQSFFAALALEIINYIEHYGLHRRVNDKGRFERVTPAHSWNSNFLLTNLALFQLQRHSDHHAYAKRRYQVLRHYEESPQLPAGYATMYVLALIPPLWRKVMNPRVEAYYEGELDQLFRDGKRVNNIA
Protein: Myb domain protein 49 (Myb-related transcription factor-like protein) (Putative transcription factor) (Q9SPG6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 22
- Heavy metal-associated isoprenylated plant protein 44
- Transcription factor bHLH101
- Transcription factor ORG2
- 11-beta-hydroxysteroid dehydrogenase-like 6
Sequence:
MGKSSSSEESEVKKGPWTPEEDEKLVGYIQTHGPGKWRTLPKNAGLKRCGKSCRLRWTNYLRPDIKRGEFSLQEEETIIQLHRLLGNKWSAIAIHLPGRTDNEIKNYWNTHIKKKLLRMGIDPVTHCPRINLLQLSSFLTSSLFKSMSQPMNTPFDLTTSNINPDILNHLTASLNNVQTESYQPNQQLQNDLNTDQTTFTGLLNSTPPVQWQNNGEYLGDYHSYTGTGDPSNNKVPQAGNYSSAAFVSDHINDGENFKAGWNFSSSMLAGTSSSSSTPLNSSSTFYVNGGSEDDRESFGSDMLMFHHHHDHNNNALNLS
Protein: Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) (O35375)
Organism: Mus musculus (Mouse)
Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O60462}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60462}.
Interaction partners:
- Semaphorin-3F
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor C
- Semaphorin-3C
- Plexin-A1
- Vascular endothelial growth factor receptor 3
- Semaphorin-3A
- Plexin-A3
- Semaphorin-3B
- Vascular endothelial growth factor receptor 2
Sequence:
MDMFPLTWVFLALYFSGHEVRSQQDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLIHQEPPENFQCNVPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKIFQANNDATEVVLNKLHMPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQTKLFEGNMHYDTPDIRRFDPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWVYDHAKWLRSTWISSANPNDRTFPDDKNFLKLQSDGRREGQYGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREASQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFAGEDFKVDIPETHGGEGYEDEIDDEYEGDWSNSSSSTSGAGDPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA
Protein: Pleckstrin domain-containing protein (Q86KG9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSDSQTTHDNNNKEVEPNEPITIVISNNGADKSLPPISQKPQLFLNNNNNNDEDSNTNTNTTTTPRSDTHDLPTINNNNNNNNNGITDEEETSPIGSYPTSWMELKSKMSQVDNSDLKRGSILIEHLSEYNKIASSQVLHEEIIQPTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKQQMTNININTNTIPLSTRIPPPPPTVKTTTININNNTPAATTTTTTTTTTPTPTPIPTPTPTTNITTTSLTQANLDSIILSGIQLFNEKPKKGIEYFFQHKLLEKTPPSVSEFLHECPLLDKKSIGDYLGDAEPFCILVLESLISRFNFKDLDFDMSLRQLLYSFRLPGEAQKIDRVVQRFANQYHKDNKEGGFIEDPDTVYTLAFAIILLNTDLHNANVKPTMTKAKFVKSLSKINSGKDLPSEFLEDMFDRILVDEIKLNPSSTLFPYAVKKGWLNIRVKGKVTDKWSRKWCVLSDGTLYFFRKPTDPSPVRYLRPDTVITSKKEIKGRKNCFMLNHSSPPITLESLIKSTQKNKSQMFNPQSLLQQLALFGKEKEKKVYFWDSAVEKFYGEQQQPQLDIQDILDTDSVSSIDTLSETSSTTNYFDDEYLSPPTSSSVSTNSSTNSTTSPTLFDQQSFDQNKKGFLRSKNGQIVECEGKMYKNGTQTLSRPPPNKNTVHYNPNFNTIHPIPQSGSSTNSYNNNNNNNNNNNNNNNNNNNNTNSNANTTTTTTTTTTTTTTNTGNSNNTSAVNHSLTQPRPNYFKTVSSSSLIRSSSISTFSTPPSSPNNNNNNNNNNNNNNNVPSSSLTSSNTSVASNNQQHNHSPAGPANSSSSSSTPVLSSTTSSSSSSSSSSSRSNTPVSHEQNNNKSEYDKNYEKNLNAFMKLQEKMIKASKNTNTCILNTDTKREMDSWIRLILHQFSKK
Protein: Protein YiiM (P32157)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YcbX
- Carnitine monooxygenase reductase subunit
- Flavohemoprotein
- Cyclic pyranopterin monophosphate synthase
- Molybdopterin synthase catalytic subunit
- GTP 3',8-cyclase
- Molybdopterin molybdenumtransferase
Sequence:
MRYPVDVYTGKIQAYPEGKPSAIAKIQVDGELMLTELGLEGDEQAEKKVHGGPDRALCHYPREHYLYWAREFPEQAELFVAPAFGENLSTDGLTESNVYMGDIFRWGEALIQVSQPRSPCYKLNYHFDISDIAQLMQNTGKVGWLYSVIAPGKVSADAPLELVSRVSDVTVQEAAAIAWHMPFDDDQYHRLLSAAGLSKSWTRTMQKRRLSGKIEDFSRRLWGK
Protein: Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7) (O60104)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16630887}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 22
Sequence:
MEPNEGVQLFSAFPPPPPYYKLFTRENIEKVISNMEKEAKHEDDANTLQPKTEEEIESLAKLFKKPSCLTSGTYQMFGDTWRLDEAIPSLKEFGIPELYKDIKDGEDEIEVVEYDPKSNAIVGTSFTRVHDYDKNSPIENEKILEDDQHTAMKEKDNESDKTMKDVEEKTEPSLKKEEEDIQMKEPLDSQDTGAVSASSVNEGFRADQKSKDGETSDLIKIPRRAYELRFLSRSLMLNFLELLGIMAKAPEQFPSKVENIRVLLLNLHHLINDYRPHQSRESLIMLLEKQLKHEESQVELLRTHNRQMTETLEKYKSLDFNMEKEGDVIQQLKSSIKKPLSGAEDEQKSRSMFSKNDEKLKKSLELMEDVIKRDLS
Protein: Prefoldin subunit (Q585S1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDSNVTYAAQLESAAEEVAEAKQYLIKLDRRQHQLKEASRALKKTPVLGDVWLLCSGGVFVRSELKYEDTLRYLSWKMGAGERDIEDCRDALKRKVAYLAELEGPDNAIAKLYEGFELTPVN
Protein: LP02169p (Suppressor of cytokine signaling at 44A) (Q7JVF1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Elongin-C
- Elongin-B
- Cullin-5
- Cullin-2
- Tyrosine-protein kinase hopscotch
- Suppressor of variegation 2-10, isoform I
- Protein gustavus
- Suppressor of cytokine signaling at 36E, isoform D
Sequence:
MSHGDQSQNQSSQRSQALTGGGDSPRDREKEKKGWFHSLTRRKKSDSALAVTASAAVSTSGSQNNNNEVCVLEAADSSMASCSNGGTGTGTLRRRRDKDKRNVFARLRRKVGQGLSSLRNWHSMGDCDDGGTTDATYEFLTPAICPEPTLPFTHDYLRFIRKKWLEREDAHSPNQIMYKACSEMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEELKYESIVEMIEDILHRCTNDNFVCFVKVPNEMQPPFPVILKYPLSRYSNMPKLQDLCRRVLQRQMSREQLAQLPVPAQMLEYLSVERELVFQS
Protein: DNA endonuclease ctp1 (EC 3.1.-.-) (Double-strand break repair protein ctp1) (Meiotically up-regulated gene 38 protein) (Nbs1-interacting protein 1) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) (O74986)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase-dependent recombinational repair pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:19804755}. Chromosome {ECO:0000269|PubMed:19804755}. Note=Accumulates at DSBs; recruited to DSBs following phosphorylation and interaction with nbs1. {ECO:0000269|PubMed:19804755, ECO:0000269|PubMed:33836577}.
Interaction partners:
- DNA repair and telomere maintenance protein nbs1
- Double-strand break repair protein rad32
- Exodeoxyribonuclease 1
- ATP-dependent DNA helicase II subunit 2
- DNA replication ATP-dependent helicase/nuclease dna2
- ATP-dependent DNA helicase II subunit 1
- Meiotic recombination protein rec12
- DNA repair protein rhp51
- Protein kinase rad3
- DNA repair and recombination protein rad22
Sequence:
MNEEEHNKSVHWSIVYRQLGNLLEQYEVEIARLKSQLVLEKKLRIQVEKELESVKTKQISSSASSKVSSNTIQELDSTTDEDEIPGSDTVDEEDPSLNAPFSEKNQSVKIPPHSPTLPVQNASAFVKPISVPLGNVKEEKFLDTNPIGAESFESSDGEMHLRARSPEDMILLRETQPLAPLDINTLGVSDNRQKKGTEKKRPFEPEFLNDDVIRGNKRKALPAYECPDCQKFYELHGPVKESSVAPTWNDENRLGGGSLPNCKHQPLVQKVGRHRKLNIPKPIPNGFWESDFVD