wanglab/gogpt-training-data huggingface dataset:
Protein: Protein CHROMATIN REMODELING 24 (AtCHR24) (EC 3.6.4.-) (DNA excision repair protein CHR24) (Q8W103)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA helicase that acts as an essential component of the spindle assembly checkpoint (By similarity). Probable chromatin remodeling factor that regulate homologous recombination (HR) and non-homologous recombination (NHR).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- DNA-directed RNA polymerase II subunit 4
- DNA repair protein UVH3
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases II, IV and V subunit 9B
- DNA-directed RNA polymerases II, IV and V subunit 9A
- WD repeat-containing protein ATCSA-1
- Transducin/WD40 repeat-like superfamily protein
- DNA-directed RNA polymerases II and V subunit 6B
- DNA-directed RNA polymerases II, IV and V subunit 6A
- DNA-directed RNA polymerases II, IV and V subunit 3
Sequence:
MAENTASHRRKPRSLNDRHYSILQDLSAPPRQPPSSSHGEDEETKKSMIKLAGRRRLCKALPKEDEADGYDDPDLVDFYSPVKGETSLDSAGIGNKFTSWDESKEANTELAGEPNFSIITDFCSPSPQLKQKEEMQGDGGRNEIMGILDDLTSKLGTMSIQKKKDSQSNDFDACGVKSQVDKFDFEDAKSSFSLLSDLSKSSPDVVTTYNAGVNSIKDKQGKSGFAIREEQTSKEFSREWEERISNVGKQNSYSGRHFDDNSEDNRQGYNLDRGKSQCKEVDQSMKTTRHIEVSEKIRTVGRSNAAKLRDLDEDDDDDDCLILSGKKAAEMKINKPARSYNAKRHGYDERSLEDEGSITLTGLNLSYTLPGKIATMLYPHQREGLNWLWSLHTQGKGGILGDDMGLGKTMQICSFLAGLFHSKLIKRALVVAPKTLLPHWMKELATVGLSQMTREYYGTSTKAREYDLHHILQGKGILLTTYDIVRNNTKALQGDDHYTDEDDEDGNKWDYMILDEGHLIKNPNTQRAKSLLEIPSSHRIIISGTPIQNNLKELWALFNFSCPGLLGDKNWFKQNYEHYILRGTDKNATDREQRIGSTVAKNLREHIQPFFLRRLKSEVFGDDGATSKLSKKDEIVVWLRLTACQRQLYEAFLNSEIVLSAFDGSPLAALTILKKICDHPLLLTKRAAEDVLEGMDSTLTQEEAGVAERLAMHIADNVDTDDFQTKNDSISCKLSFIMSLLENLIPEGHRVLIFSQTRKMLNLIQDSLTSNGYSFLRIDGTTKAPDRLKTVEEFQEGHVAPIFLLTSQVGGLGLTLTKADRVIVVDPAWNPSTDNQSVDRAYRIGQTKDVIVYRLMTSATVEEKIYRKQVYKGGLFKTATEHKEQIRYFSQQDLRELFSLPKGGFDVSPTQQQLYEEHYNQIKLDEKLESHVKFLETLGIAGVSHHSLLFSKTAPIQAIQKDEEEQIRRETALLLGRASASISQDTVINGADYAFKPKDVNLDKRINISPVDDKELSESVIKARLNRLTMLLQNKGTVSRLPDGGAKIQKQIAELTRELKDMKAAERINMPQVIDLEEDISRKMQKGLNL
Protein: Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] (P01194)
Organism: Rattus norvegicus (Rat)
Function: Stimulates the adrenal glands to release cortisol.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01193}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
Interaction partners:
- Melanocortin receptor 4
- Adrenocorticotropic hormone receptor
- Mu-type opioid receptor
- Melanocortin receptor 3
- Melanocortin receptor 5
- Melanocortin 2 receptor accessory protein
- Kappa-type opioid receptor
- Proenkephalin-B
- Proenkephalin-A
- Delta-type opioid receptor
Sequence:
MPRFCNSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEQVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNVHKKGQ
Protein: Zinc finger protein 207 (X6R4W8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAMSSLGCLCALTVLIRYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY
Protein: Proteasome subunit alpha type-8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) (Q9CWH6)
Organism: Mus musculus (Mouse)
Function: Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds (Probable). Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Subcellular location: Nucleus {ECO:0000269|PubMed:31437213}. Note=Localizes to the central region of the synaptonemal complex. {ECO:0000269|PubMed:31437213}.
Interaction partners:
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-6
- Proteasome subunit beta type-7
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3
- Proteasome subunit beta type-8
- Proteasome subunit beta type-2
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-5
- Proteasome activator complex subunit 4
Sequence:
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVISRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAISNDKEAIKLAIKALLEVVQSGGKNIELAIIRRDQPLKMFSAKEIELEVSEIEREKDEAEKTKSKKST
Protein: Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) (P22301)
Organism: Homo sapiens (Human)
Function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Interleukin-10 receptor subunit alpha
- Interleukin-10 receptor subunit beta
- Interleukin-6
- Interferon gamma
- Tumor necrosis factor
- Interleukin-1 beta
- Interleukin-7
- Interleukin-4
- Interleukin-5
- Interleukin-17A
Sequence:
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
Protein: Roundabout homolog 3 (Retinoblastoma-inhibiting gene 1 protein) (Rig-1) (Roundabout guidance receptor 3) (Q9Z2I4)
Organism: Mus musculus (Mouse)
Function: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.
Subcellular location: Membrane {ECO:0000269|PubMed:10049565}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Protein kinase C-binding protein NELL2
- Slit homolog 3 protein
- Slit homolog 2 protein
- Roundabout homolog 1
- Slit homolog 1 protein
- Regulator of nonsense transcripts 2
- RNA-binding protein Musashi homolog 1
- Netrin-1
- Regulator of nonsense transcripts 1
Sequence:
MLRYLLKTLLQMNLFADSLARDISNSSELLFGFNSSLAALNPSLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLVVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECVPPKGHPEPLVTWKKGKIKLKEEEGRITIRGGKLMMSHTFKSDAGMYMCVASNMAGERESGAAELVVLERPSFLRRPINQVVLADAPVNFLCEVQGDPQPNLHWRKDDGELPAGRYEIRSDHSLWIDQVSSEDEGTYTCVAENSVGRAEASGSLSVHVPPQFVTKPQNQTVAPGANVSFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPMGRLLVSPRGQLNITEVKIGDGGYYVCQAVSVAGSILAKALLEIKGASIDGLPPIILQGPANQTLVLGSSVWLPCRVIGNPQPNIQWKKDERWLQGDDSQFNLMDNGTLHIASIQEMDMGFYSCVAKSSIGEATWNSWLRKQEDWGASPGPATGPSNPPGPPSQPIVTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVQTQDSSLSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTLQVSWTVDGPVQLVQGFRVSWRIAGLDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPPQGVAVALGGDRNSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAATSAGVGVASAPVLVQLPFPPAAEPGPEVSEGLAERLAKVLRKPAFLAGSSAACGALLLGFCAALYRRQKQRKELSHYTASFAYTPAVSFPHSEGLSGSSSRPPMGLGPAAYPWLADSWPHPPRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGANASGEGPVYSTIDPVGEELQTFHGGFPQHSSGDPSTWSQYAPPEWSEGDSGARGGQGKLLGKPVQMPSLSWPEALPPPPPSCELSCPEGPEEELKGSSDLEEWCPPVPEKSHLVGSSSSGACMVAPAPRDTPSPTSSYGQQSTATLTPSPPDPPQPPTDIPHLHQMPRRVPLGPSSPLSVSQPALSSHDGRPVGLGAGPVLSYHASPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKKPKALPYRREHSPGDLPPPPLPPPEEETSWPLGLRAAGSMSSLERERSGERRVVQAVPLGAQPLGAQRGPHPDAALLGCAAEEAWLPYGRPSFLSHGQGTSTCSTAGSNSSRGSNSSRGSRGSRGPGRSRSRSRSQSQSQRPGRNRREEPR
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (E9PEQ6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETVWSDDDWLKKFSGKTLEENKEEEGSEPPKAETQEGEPIAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQIEAQGSKDGKPKQKVIIADCGEYV
Protein: Spastin (EC 5.6.1.1) (E5KRP5)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Membrane {ECO:0000256|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_03021}. Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03021}. Midbody {ECO:0000256|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000256|HAMAP-Rule:MF_03021}. Cytoplasm, perinuclear region {ECO:0000256|HAMAP-Rule:MF_03021}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|HAMAP-Rule:MF_03021}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03021}. Note=Forms an intramembrane hairpin-like structure in the membrane. Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Localizes to endoplasmic reticulum tubular network. {ECO:0000256|HAMAP-Rule:MF_03021}.
Interaction partners:
Sequence:
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAKMMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
Protein: Expansin (F4HPC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000256|RuleBase:RU365023}. Membrane {ECO:0000256|RuleBase:RU365023}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365023}.
Interaction partners:
Sequence:
MCRLLTQDVNMGHLGFLVMIMVGVMASSVSGYGGGWINAHATFYGGGDASGTMGGACGYGNLYSQGYGTSTAALSTALFNNGLSCGSCFEIRCENDGKWCLPGSIVVTATNFCPPNNALANNNGGWCNPPLEHFDLAQPVFQRIAQYRAGIVPVSYRRVPCRRRGGIRFTINGHSYFNLVLITNVGGAGDVHSAAIKGSRTVWQAMSRNWGQNWQSNSYLNGQALSFKVTTSDGRTVVSFNAAPAGWSYGQTFAGGQFR
Protein: Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) (Q91XS8)
Organism: Rattus norvegicus (Rat)
Function: Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains.
Subcellular location: Nucleus {ECO:0000269|PubMed:11481038}. Cell membrane {ECO:0000269|PubMed:11481038}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:11481038}. Note=Colocalizes with STK17B at the plasma membrane.
Interaction partners:
Sequence:
MSRRRFDCRSISGLLTTTPQTPMKTENFNNFYTLTPKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELARSCPHVINLHEVYETATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQQWDFGSLFHPEETSESSQTQDLSLRSSEDKTPKSCNGSCGDREDKENIPEDDSLLSKRFRFDDSLPSPHELVPDLFC
Protein: L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) (Q9LES4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of (S)-2-hydroxyglutarate to 2-oxoglutarate. Is specific for the (S) enantiomer and possesses very poor activity toward (R)-2-hydroxyglutarate. Has no activity toward related 2-hydroxy acids, such as glycolate, L-lactate or D-lactate.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24561575}.
Interaction partners:
- Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
- Isovaleryl-CoA dehydrogenase, mitochondrial
- Vacuolar protein sorting-associated protein 52 A
- Glutamate decarboxylase 1
- Vacuolar protein sorting-associated protein 52 B
- Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial
- glutamate dehydrogenase
- Glutamate dehydrogenase 2
- Probable glutamate dehydrogenase 3
- Glutamate dehydrogenase 1
Sequence:
MKHKPETAAFSLIRPLEAWAANANKACNTKKMLPCLGRKWMRLSTRNLKPTWNLINVVDASKTIVRGISGGAETIAKERVDTVVIGAGVVGLAVARELSLRGREVLILDAASSFGTVTSSRNSEVVHAGIYYPPNSLKAKFCVRGRELLYKYCSEYEIPHKKIGKLIVATGSSEIPKLDLLMHLGTQNRVSGLRMLEGFEAMRMEPQLRCVKALLSPESGILDTHSFMLSLVEKSFDFMVYRDNNNLRLQGEAQNNHATFSYNTVVLNGRVEEKKMHLYVADTRFSESRCEAEAQLELIPNLVVNSAGLGAQALAKRLHGLDHRFVPSSHYARGCYFTLSGIKAPPFNKLVYPIPEEGGLGVHVTVDLNGLVKFGPDVEWIECTDDTSSFLNKFDYRVNPQRSEKFYPEIRKYYPDLKDGSLEPGYSGIRPKLSGPKQSPADFVIQGEETHGVPGLVNLFGIESPGLTSSLAIAEHIANKFLR
Protein: Protein PHOTOPERIODIC CONTROL OF HYPOCOTYL 1 (F-box protein PCH1) (Q84V03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:29263319}. Note=Observed in subnuclear light-induced structures called photobodies. {ECO:0000269|PubMed:29263319}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Putative F-box protein At2g33655
- F-box protein At1g11270
- GDSL esterase/lipase At5g55050
- Protein EARLY FLOWERING 4
- Probable cysteine protease RD21C
- Uncharacterized protein At4g25920
- Putative F-box protein At5g55150
- Protein EARLY FLOWERING 3
Sequence:
MSEHVMVLGKGNKGISKNSSVNPYESAWLGRWTQSGSEVKFHDGETNCSKQLIRPEDENHGVEVLPFPMFKVSQKRETTTTTTTKPSFHEDVGSSSRAMVNRMPWMYPQGENFSSSNRLDFPIQEKTTQNLLELIRPVRIYATVDSVNLPKEDSHQLLKGSTVSMKLKGKIFGGYLDLFPNQDHSHNRGGVRLQSLESSKDTQEDGPRKNESSAETNTLEMDRLQTIHLSGSISSSSTKGKGIKGYSAIPRTEIPDMNEEPPLVPDRENSVDGHQGETSNSATQSMNVEHFLSRDCKRVRLEPEVEASSRWVKRLKTSPSDSSETKSMMKMKEASLGEKENNNLFLEILKSGINNLQPRNQEPVVSQSNDLRQGGDDITLLHPWIQRWCKKKTTSTDQPTGQEASFEPESHKEFEKKQYPSIAAMALMGKALSGLNPYGLRKTNSLMVWNARDLSFTYRSLRWNLTMADWPLLPNDLLELIMGHLETSFEIFLFRSVCSSWRSVVPPLDHSRCLGIKTHDISFNVGFSFNGRPTNEYCTLKKIPIYLVKFWTPFGDDYLLAEMRERNDGEPKLLLSPLSSNGIKYGMGINKVLFNSLTSPIIPFGQYYEITYIEKRPSEYRFGFPYKLEWVEITERVEFLKLDSEDSRDFAVLFAGRMCNLVMYRSRNMSWTQVVEHPEKYAYQDLVAFKGKFYAVDSSGRGRVFVVELSFEVTEIPSVGGSQQSSKESLVQSGEELLLVQRFTPVGRRYDEYIYIHGSECLDLMKKEERESGFKLMT
Protein: Geranylgeranyl pyrophosphate synthase (EC 2.5.1.29) (Polyprenyl synthetase family protein) (Q6N9M1)
Organism: Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Interaction partners:
- Geranylgeranyl diphosphate reductase
- CrtB phytoene synthase
- Isoprenyl transferase
- Methyltransferase
- Chlorophyllide reductase subunit Z
- Carotenoid 1,2-hydratase
- Methoxyneurosporene dehydrogenase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
- 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase
Sequence:
MDVTNRIERALTEALNQADMAGCPPRLAAAMRSAVFPRGARVRPRLCHSVALACGEDNPGITEAAGAALELMHCASLIHDDLPCFDGADLRRGRPSVHKAFGEPLAVLAGDAMIVLAFQTIARAEGQADRLLKLTQIIGGAVGVPFGIVAGQAWECETEINLAHYHRSKTGALFVAATAMGAASAGSDPEPWRMVGEKIGEAYQVADDLRDAAADVEEIGKPVGQDVAHDRPSAVREMGIDGAIYHLKSLVRGAVEAMPECTNGNELRSLIMSEATRLVPAKLAATAA
Protein: RE59129p (Q8MYX5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQPQQSVSQSPLREQQTAANTSSKSTAAANRDKINPLTLSLACPTQTKCMKLKSKLMVGPDEGGGRSICLRFSTSQRGEEAKAAVSTAIAKYAFFVVNSKEQLIYYGSDTKLNFGMGLIIFGFNFTLTP
Protein: Germacrene A acid 8-beta-hydroxylase (HaG8H) (EC 1.14.14.168) (Cytochrome P450 71BL1) (F8S1H3)
Organism: Helianthus annuus (Common sunflower)
Function: Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Hydroxylates germacrene A acid to 8-beta-hydroxy-germacrene A acid. Unlike 6-alpha-hydroxy-germacrene A acid, this compound cannot undergo spontaneous lactonization.
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MELFTIFSIVVSSLILFTFWSLKVPKNLPPGPPKLPIIGNIHLLDKIAPHRNLRNLARKYGPIMHLRLGQVSTVVISSPRLAHEIMKTQDLSFADRPTTTTSQIFFYKASNIAWARYGNYWRQMKKICTLELLSAKKSRSFFYIREEELTRTYKFLDFSSGTPITLRDTIQEMVNNVVSRATLGDVSEDRQFIIDSTYTMLKSFNSFNLFNYYPSLSFINVISGKQAQWLKMHKEVDVILEKILREHRSRPRGKNDHEDLVDVLIRIKETGDLDMAITDDNIKAIILEMLTAGTSSSSMTIEWAFTEMMRNPKIMKKAQTEVRSVVKGDRVTEADIQNLDYTKLVIKETLRLHGVPILVPRENQEDCVVNGYDIPAKTRLLVNAWACATDPDSWEDPDSFIPERFENNSIGYSGADFEFIPFGAGRRICPGMNFGMGTVEYVVANLLLHYDWKLPDGMKPHDIDMREITGISTLPIHPLKIVPISLSK
Protein: Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (P50398)
Organism: Rattus norvegicus (Rat)
Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
Subcellular location: Cytoplasm. Golgi apparatus, trans-Golgi network {ECO:0000250}.
Interaction partners:
- small monomeric GTPase
- Ras-related protein Rab-8A
- Ras-related protein Rab-1B
- Ras-related protein Rab-10
- Ras-related protein Rab-6A
- Ras-related protein Rab-6B
- Ras-related protein Rab-5A
- small monomeric GTPase
- Ras-related protein Rab-8B
- Ras-related protein Rab-9A
Sequence:
MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETAEPEKEVEPALELLEPIDQKFVAISDLYEPIDDGSESQVFCSCSYDATTHFETTCNDIKDIYKRMAGSAFDFENMKRKQNDVFGEADQ
Protein: Protein SOSEKI 3 (AtSOK3) (Q8GYT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30737509}; Peripheral membrane protein {ECO:0000269|PubMed:30737509}; Cytoplasmic side {ECO:0000269|PubMed:30737509}. Note=SOSEKI proteins integrate apical-basal and radial organismal axes to localize to polar cell edges. {ECO:0000269|PubMed:30737509}.
Interaction partners:
- Transcription factor PRE3
Sequence:
MEARMKKYSREVSPERAKVWTEKSPKYHQKIKKVQIVYYLSKNRQLEHPHFMEVLISSPNGLYLRDVIERLNVLRGRGMASMYSWSSKRSYRNGFVWHDLSEDDLILPANGNEYVLKGSELFDESNSDHFSPIVNLATQNMKQIVVEPPSSRSMDDSSSSSSMNNGKGTNKHSHEDDELSPPALRSVSSSGVSPDSRDAKNSSSWCLAEYKVYKSEGLADASTQTDETVSGRSKTPIETFSRGVSTDEDVSSEPETSENNLVSEASCAGKERESAEISRNSVSPPFSNSASSLGGKTDTLESLIRADVSKMNSFRILEQEDVRMPAIPRLRASNMLMQLISCGSISVKDNNFGLVPTYKPKFGHSKFPSPFFSSSFMMGDLDRLSETPSLMGLRMEEKEYFSGSLVETKLQKKDAADSNASLKRSSSYNGDRASNQMGVAENGDSKPDSSKNNPSSRKASSILGKQQPLVSEKRRDSSEDTTKNIPCTTKTHDACSKRITESLRKPDSFREDEERVIKIDERLASGARVRIESKVPSEEP
Protein: Proepiregulin [Cleaved into: Epiregulin (EPR)] (O14944)
Organism: Homo sapiens (Human)
Function: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
Subcellular location: [Epiregulin]: Secreted, extracellular space {ECO:0000269|PubMed:9337852}.; SUBCELLULAR LOCATION: [Proepiregulin]: Cell membrane {ECO:0000269|PubMed:9337852}; Single-pass type I membrane protein {ECO:0000269|PubMed:9337852}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Epidermal growth factor receptor
- Amphiregulin
- Receptor tyrosine-protein kinase erbB-3
- Proheparin-binding EGF-like growth factor
- Pro-epidermal growth factor
- Protransforming growth factor alpha
- Receptor tyrosine-protein kinase erbB-2
- Pro-neuregulin-1, membrane-bound isoform
- High affinity nerve growth factor receptor
Sequence:
MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
Protein: Photosystem II reaction center protein L (PSII-L) (Q2LIL5)
Organism: Oryza glumipatula
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01317}.
Interaction partners:
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: INO80 complex subunit 2 (O14210)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- INO80 complex subunit 4
- Chromatin-remodeling complex subunit ies6
- Actin-like protein arp5
- Probable actin-related protein 8
- RuvB-like helicase 2
- Actin-related protein 4
- RuvB-like helicase 1
- SWI/SNF and RSC complexes subunit arp42
- Transcription initiation factor TFIID subunit 14
- INO80 complex subunit 1
Sequence:
MARRRSTRRALVETPSDLNAQDSDSLSVSTKEELGDDALAAEEGQSVLDEQEIEEALEEDDTNYEEDIIDDEESAQVDEEELEEEEEEEEDATPEPVVTSKKNSRSKPKNGGASKRKASRRTVVDEDSENLEGDEEDGSFSDLKDLYSNPMPAQTTPVSMRMTKRQRAIQGILEEGEEDELLELPPETSGRKKLTPEEMALRRIENARRRKNQSERRLEEEKMETINRLLKRQSNTGKPRRGRAPNNPTSDSISRSKAVPKDRINMYQPFQCVRFKSTKEGSSLGVPEPLIRFFS