wanglab/gogpt-training-data huggingface dataset:
Protein: Thioredoxin domain-containing protein 15 (Q6P6J9)
Organism: Mus musculus (Mouse)
Function: Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis.
Subcellular location: Cell projection, cilium membrane {ECO:0000305|PubMed:29459677}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MQLLCWWQVLLWVLGLPAHGLEVAEDSGHPWREERPVPALQVGAVYLHEEEVAQDHRDQARAAEPMEASLGPRGDPMVVLSVVPGAAEDQRSPEAHDGTCSAQGEEDPSCGRENLFGLQGAGGFQDREEEYYAEPGVTEAEPVATEDANSTDSLKSPKVNCEERNVTGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPTLGFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQMGPLPSTLIKTVDWLLVFSLFFLISFIMYATIRTESIRWLIPGQEQEHAE
Protein: Cyclin N-terminal domain-containing protein (Q387H2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cyclin dependent kinase-binding protein, putative
Sequence:
MGFSDGAVVKLLHEIVGDQSVPQVEQFPSFGGLRKHDFPTPLVFVFCGESWPTSLQSCSLQEMGSCSFSMAPDDSLTSLQLEPLSIIDEEGSASGDCGSRGALMTRFQLVGTVFVIERYQLFSTKDSASKSFSEECNEVTRSTVIVRVTIDASRSLGDQKVVARPVVLSEDEGLHHAFFNTLKPVVRLNMSNCDEASDSSATFGSSPSDAESGQGLSGSQSSGDSNSDWTNGLSYGNCAAEPTPLHPNPVDSHPAPGTVHGDAVDKACEPSIFPSASLPTGFDLRRATIYSMLDQEAYQNIDVYRGWNNLTDEWSDVSRPAVVNLIDVIVTCLKCSRAAAHAAISYLDAYVAGVDNLPRGRTFFSGIVHACAVLGCKQVDHFFSPTKQFMEYLRSSCRITGKDFVRFELEVLVKLDFRLQQLTSLEIVETLLHLCGGAAIEEALEARCRRRELARWDKAAAWDAESTTKVDCEGTLRGLDQWLKLCDCARLLNDVVVRETRSTMLRPVVLGVAIVVVAARWVAYRLPQPLLELVPTRFASAAWADEGPVLDEMSFQLLVTFAERARLRDDDQAHCGIGEELITGLEFVEECLRFCDGGTLDEVLRQRYRHTLKS
Protein: Type IV secretion system protein virB8 (Q2YJ78)
Organism: Brucella abortus (strain 2308)
Function: The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Type IV secretion system protein VirB6
- Type IV secretion system protein virB3
- Type IV secretion system protein virB9
- Type IV secretion system protein VirB11
- Type IV secretion system protein virB4
- Type IV secretion system protein virB10
- Type IV secretion system protein virB1
- Type IV secretion system protein virB2
- Type IV secretion system putative lipoprotein virB7
- Type IV secretion system protein virB5
Sequence:
MFGRKQSPQKSVKNGQGNAPSVYDEALNWEAAHVRLVEKSERRAWKIAGAFGTITVLLGIGIAGMLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKYWLSQYVIARETYDWYTLQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSVTIVSIVPNGKGIGTVRFAKTTKRTNETGDGETTHWIATIGYQYVNPSLMSESARLTNPLGFNVTSYRVDPEMGVVQ
Protein: Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3) (Q86SG2)
Organism: Homo sapiens (Human)
Function: May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.
Subcellular location: Nucleus. Note=Sarcomeric I-band and some intercalated disks. {ECO:0000250}.
Interaction partners:
- Titin
- Myopalladin
- Ankyrin repeat domain-containing protein 39
Sequence:
MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLERFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRTRC
Protein: Silenced mating-type protein A1 (MATa1 protein) (P0CY11)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of A1 at HMR.
Subcellular location: Nucleus.
Interaction partners:
- Silenced mating-type protein ALPHA2
- Silenced mating-type protein ALPHA1
- Zinc finger protein RME1
- Mating hormone A-factor 2
- Pheromone alpha factor receptor
- Alpha-factor-transporting ATPase
- A-agglutinin-binding subunit
- Mating hormone A-factor 1
- Homothallic switching endonuclease
- Protein ASG7
Sequence:
MDDICSMAENINRTLFNILGTEIDEINLNTNNLYNFIMESNLTKVEQHTLHKNISNNRLEIYHHIKKEKSPKGKSSISPQARAFLEQVFRRKQSLNSKEKEEVAKKCGITPLQVRVWFINKRMRSK
Protein: AT20009p (Fumble, isoform C (EC 2.7.1.33)) (Fumble, isoform D) (Q8I0S6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSSTADEPPEKAPTSKHSTR
Protein: DEAD-box ATP-dependent RNA helicase 50 (EC 3.6.4.13) (Q8GUG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in resistance to biotic and abiotic stresses.
Interaction partners:
- DExH-box ATP-dependent RNA helicase DExH15 chloroplastic
- RNA helicase
- Pescadillo homolog
- Protein MODIFIER OF SNC1 11
- DExH-box ATP-dependent RNA helicase DExH10
- ATP-dependent RNA helicase DEAH12, chloroplastic
- Protein PIGMENT DEFECTIVE 338, chloroplastic
- Probable rRNA-processing protein EBP2 homolog
- Nuclear protein-like
Sequence:
MLARAPPPYFNFPARNNTICNRNEIVRLFRNGGGVVARGAGFTRRPLETSSSYDDSTDDGFVIISAADKENEFAPPPSSDLLSSIPSESARRNGSRSRGLTASFGRLKAQKVKALVGKVTQKKQHMSHNEEEDEDDASDENYSADEGFGSSSILDLMRKKLAMKAIPRSGKSAERNEVKRASKVRESRESRRDLDRLEGDDEDVDEVSNPDRFTDNQRAGSRSSYSKGGYAANSRGKGDRLSVARDLDSFEGHGRAIDEVSNPRKFNDNERAESRSSYSRDSSANSRGREDRRFVAKELDTFQGRDKAYDEVYNPRRFTDNERGLRGGSHSKGSDTNSRGWGDRRSVVYTRDMDDWRERNKTKDTRETGFFSRKTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQGHSKSSPGCPRVIVLVPTAELASQVLANCRSISKSGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFGDDEFEAALQNLINSSPVTAQYLFVTATLPLEIYNKLVEVFPDCEVVMGPRVHRVSNALEEFLVDCSGDDNAEKTPETAFQNKKTALLQIMEENPVSKTIIFCNKIETCRKVENIFKRVDRKERQLHVLPFHAALSQESRLTNMQEFTSSQPEENSLFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARGKGKAFIFVVGKQVGLARRIIERNEKGHPVHDVPNAYEFTT
Protein: Cell adhesion molecule-related/down-regulated by oncogenes (Q32MD9)
Organism: Mus musculus (Mouse)
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Sonic hedgehog protein
- Protein patched homolog 1
- Indian hedgehog protein
- Desert hedgehog protein
- Growth arrest-specific protein 1
- Protein patched homolog 2
- Brother of CDO
- Low-density lipoprotein receptor-related protein 2
- Protein smoothened
- Cadherin-15
Sequence:
MHPDLGPLWTLLYVLVILCSSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAAALGDFDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWLKHSTGNYIILPSGNLQVLNVSSKDKGSYKCAAYNPVTSELKVEPTGRKLLVSRPSSNGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDAVAGSNWRRLYSHLATASIDPADSGNYSCVVGNKSGDVKHVTYMVNVLEHASISKGLHDQKVSLGATVHFTCDVHGNPAPNRTWFHNAQPIHPSSRHLTEGNVLKITRVVMEDSGLYQCVADNGIGFMQSTGRLQIEQDSGWKPVIVTAPANIEVMDGDFVTLSCNATGVPVPVIHWYGRHGLITSHPSQVLRSKPRKSHLFRPGDLDLEPVYLIMSQAGSSSLSIQAVTLEHAGKYTCEATNKHGSTQSEAFLTVVPFETNTKAESVTPSEASQNDERDPQDGSESSLLNLFPVKVHPSGVELPAERNASVPDAPNILSPPQTHMPDTYNLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSENELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGVPKRPVTAEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMRTSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYVPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASDYPVKELSTPPSSSGNAGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIALCLWKSRQQSTIQKYDPPGYLYQGSEINGQMVEYTTLSGAARINGSVHGGFLSNGCSHLHHKGPSGVNGTLSGNINGGLYSAHTNSLTRACVEFEHPHHLVNSGGVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQGGLEMKPLNAMKVPVCPASTVPDHGQLPDDCVKDSVAPIPTQHTCCQDNISDINSDSTEDTAEFSRGDSSGHSEAEDKVFSWNPLILSPVLEDCGEKTARSPPGPPLDGLSVVLQQAQET
Protein: TSC22 domain family protein 3 (Glucocorticoid-induced leucine zipper protein) (TSC22-related-inducible leucine zipper 3) (Tilz3) (Q9Z2S7)
Organism: Mus musculus (Mouse)
Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20124407}. Nucleus {ECO:0000269|PubMed:20124407}. Note=Localization depends on differentiation status of myoblasts (PubMed:20124407). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (PubMed:20124407). {ECO:0000269|PubMed:20124407}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:20124407}. Nucleus {ECO:0000269|PubMed:20124407}. Note=Localization depends on differentiation status of myoblasts (PubMed:20124407). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblasts; localizes to the nucleus (PubMed:20124407). {ECO:0000269|PubMed:20124407}.
Interaction partners:
- Serine/threonine-protein kinase Sgk1
- RAF proto-oncogene serine/threonine-protein kinase
- E3 ubiquitin-protein ligase NEDD4-like
- Peptidyl-prolyl cis-trans isomerase FKBP5
- Epithelial sodium channel subunit alpha
Sequence:
MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEVLKEQIRELLEKNSQLERENTLLKTLASPEQLEKFQSRLSPEEPAPEAPETPETPEAPGGSAV
Protein: Protein RALF-like 22 (Q9MA62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Proline-tRNA ligase
- Putative beta-glucosidase 41
- At4g12520
- Protein BIIDXI
- Signal peptide peptidase
- Putative pentatricopeptide repeat-containing protein At5g43820
- Peroxidase 69
- Probable pectinesterase 48
- BIIDXI-like protein At5g11420
- Protein DUF642 L-GALACTONO-1,4-LACTONE-RESPONSIVE GENE 2
Sequence:
MTNTRAIYAVIAILAIVISAVESTGDFGDSLDFVRAGSSSLFSGCTGSIAECIAEEEEMEFDSDISRRILAQKKYISYGAMRRNSVPCSRRGASYYNCQRGAQANPYSRGCSTITRCRR
Protein: Metaxin-2 (Mitochondrial outer membrane import complex protein 2) (O88441)
Organism: Mus musculus (Mouse)
Function: Involved in transport of proteins into the mitochondrion.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:10381257}. Mitochondrion {ECO:0000250|UniProtKB:O75431}.
Interaction partners:
- Sorting and assembly machinery component 50 homolog
- Metaxin-1
- DnaJ homolog subfamily C member 11
- MICOS complex subunit Mic19
- MICOS complex subunit Mic60
- MICOS complex subunit Mic25
- Mitochondrial import receptor subunit TOM7 homolog
- Metaxin
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import receptor subunit TOM70
Sequence:
MSLVAEAFVSQIAATEPWPENATLYQQLRGEQILLSDNAASLAVQAFLQMCNLPVKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLDEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITIARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGNKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTSDELSEKVKNYSNLLAFCRRIEQHYFEDWGKGRLS
Protein: Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (Q6IQ73)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Programmed cell death 6-interacting protein
- Charged multivesicular body protein 7
- Charged multivesicular body protein 3
- Charged multivesicular body protein 2a
- vesicle-fusing ATPase
- vesicle-fusing ATPase
- IST1 homolog
- Charged multivesicular body protein 1b
- Vesicle
- Charged multivesicular body protein 1a
Sequence:
MSVFGKLFGGGGKGGKGPTPQEAIQKLRETEEMLAKKQDFLEKKIDAELLIAKKNGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGFAAKAMKTAHENMDIDKVDDLMQDITEQQELAQEISDAISRPVGFGEEFDEDELMAELEELEQEELDKDLLQISGPEDVPLPNVPSNPLPKKTAVAQKKRQEEDEDDMEELKAWAM
Protein: Tetratricopeptide repeat protein 21A (TPR repeat protein 21A) (Tetratricopeptide repeat-containing hedgehog modulator 2) (Q8C0S4)
Organism: Mus musculus (Mouse)
Function: Intraflagellar transport (IFT)-associated protein required for spermatogenesis. Required for sperm flagellar formation and intraflagellar transport.
Interaction partners:
- WD repeat-containing protein 19
- Intraflagellar transport protein 140 homolog
- Intraflagellar transport protein 122 homolog
- Intraflagellar transport protein 43 homolog
- WD repeat-containing protein 35
- Tetratricopeptide repeat protein 29
- Cilia- and flagella-associated protein 43
- Fibrous sheath-interacting protein 2
- Intraflagellar transport protein 81 homolog
- Sperm flagellar protein 2
Sequence:
MSSDDSSLMASIIYYSQEKYFHHVLQAANVGLERYSSDPALQFFRAYGILGEDHIHDAISELEGIQSHPDTSLCAVIALLSAHKSCDTIDIEAVQELESSLKEIRRSASSTALYYASLFLWFMGHHDKAREYVDHMLKVSSGSKEGYVLKGWVDLTSSKPHVVKKSIKYLEQGTQDTKDVLGLMGKATYFMTQQNFSGALEVANQVTLACSNFLPALVLKMKLFLARQDWDQTIETGQRILEKDENNIDAWQILAVHELVKEGNTDRAADRVRNLIKALETGEPHNPNLHLKKILVISRLCGRHQVVHRLVSGFLERIFMATPSCALVATELGYLFILHQQVKEACLWYKEAMKLEENRLAALAGSIWCQILQGQLEEAAHQLEFLKEVQQSLGKSELLVFLQALVAAKKQRLEQEATALLKEAVEVHFSSMQGLALSPEYFEKLDPLFLVCIAKEYLHFCPKQPRSPGQLVSPLLKQVAMILSPVVKVAPAMMEPLYVTAQVKFLSGELENAQSTLQRCLELDPTFVDAHLLMSQIYLAQGNFAMCSHCLELGVSHNFQVRDHPLYHFIKARALNKTGDYAEAIKTLKMIIKVPTSKAEEGRKSQSPSVRPSERASILLELVEALRLNGELHEATKIMQDAINEFSGTPEEMRITVANVDLALSKGNVDLALNMLRGITPKQPCYTEAKEKMASIYLHTRKDVRLYIGCYVELCEHLPGPHSSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLVSRIGQAYVKTHQYAKAINYYEAAQKISGQDFLCCELAELLLKLKKYHKAEKVLKQALERDSGVKDIPSMINEVKCLLLLAKVYKSHKKEEVMETLNLALDLQSRILKRVPLEQSEMIPFQNQLAASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVSSRVPLEPGFNYCQGIYFWHIGQPNEALRFLNKARKDSTWGQLATCYMVQICLNPDNEIVGGEAFESLVGDSNSASRKESQQHGVRTAEKLLREFYPHSESGQTQLRLLQNLCLLATREKANVEVALGAFIEMAQAEKDSIPALLAMAQAYILLKQVPKARTQLKRLAKVPWTVDEAEDLEKSWLLLADIYCQGGKFDLALELLRRCLQYNKSCCRAYEYMGFIMEKEQSYKDAATNYELAWKYSHQANPAIGFKLAFNYLKDKKFVDAIEVCHSVLTEHPKYPKIREEILEKAQGSLRP
Protein: Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) (Q93052)
Organism: Homo sapiens (Human)
Function: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
Subcellular location: Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.
Interaction partners:
- LIM and SH3 domain protein 1
- High mobility group AT-hook 2
- Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
- Vasodilator-stimulated phosphoprotein
Sequence:
MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL
Protein: Large ribosomal subunit protein mL63 (Mitochondrial ribosomal protein 63) (Mitochondrial ribosomal protein L57) (Ribosomal protein 63, mitochondrial) (mMRP63) (Q9CQF8)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Large ribosomal subunit protein mL50
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL52
- Large ribosomal subunit protein mL64
- 39S ribosomal protein L40
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein uL30m
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL41
Sequence:
MFLTAVLLRGRIPGRQWIGKHRRPRTVSFQAKESMIRRLEVEAENHYWLSMPYMTAEQECGHAAERRAQAFEAIKAAATSKFPKHRYIADQLDHLNISKKWS
Protein: Galactose-3-O-sulfotransferase 4 (Gal3ST-4) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 4) (Gal-beta-1,3-GalNAc 3'-sulfotransferase) (Q96RP7)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGPLSPARTLRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRQPSAPSLRPALPSCPPRQRLVFLKTHKSGSSSVLSLLHRYGDQHGLRFALPARYQFGYPKLFQASRVKGYRPQGGGTQLPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKSPSLAAFLANPRGFYRPGARGDHYARNLLWFDFGLPFPPEKRAKRGNIHPPRDPNPPQLQVLPSGAGPRAQTLNPNALIHPVSTVTDHRSQISSPASFDLGSSSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGHKQGLSTVSNSGLTAEDRQLTARARAWNNLDWALYVHFNRSLWARIEKYGQGRLQTAVAELRARREALAKHCLVGGEASDPKYITDRRFRPFQFGSAKVLGYILRSGLSPQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKTSRPLSP
Protein: Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Q9UPT9)
Organism: Homo sapiens (Human)
Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:32130408}. Cytoplasm {ECO:0000250|UniProtKB:Q5DU02}.
Interaction partners:
- Transcription and mRNA export factor ENY2
- Ataxin-7
- Ataxin-7-like protein 3
- Transformation/transcription domain-associated protein
- SAGA-associated factor 29
- Histone acetyltransferase KAT2A
- Transcription initiation factor TFIID subunit 10
- Transcriptional adapter 3
- Transcription initiation protein SPT3 homolog
- Transcription initiation factor TFIID subunit 9B
Sequence:
MVSRPEPEGEAMDAELAVAPPGCSHLGSFKVDNWKQNLRAIYQCFVWSGTAEARKRKAKSCICHVCGVHLNRLHSCLYCVFFGCFTKKHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYIYDKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLDSEGYLLFYHKQFLEYE
Protein: Putative auxin response factor 21 (Q9C8N9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Putative non-specific lipid-transfer protein 14
- Auxin-responsive protein IAA33
- Tropinone reductase homolog At2g29170
- Mitotic spindle checkpoint protein MAD2
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 2
- Auxin-responsive protein IAA32
- Anaphase-promoting complex subunit 6
Sequence:
MESGNIVNAQPKLSGIIDGSKSYMYEQLWKLCAGPLCDIPKLGENVYYFPQGNIELVQASTREELNELQPICDLPSKLQCRVIAIHLKVENNSDEIYAEITLMPDTTQVVIPTQSENRFRPLVNSFTKVLTASDTSAYGGFSVPKKHAIECLPPLDMSQPLPAQEILAIDLHDNQWRFRHNYRGTPQRHSLTTGWNEFITSKKLVKGDVIVFVRGETGELRVGIRRARHQQGNIPSSIVSIDCMRHGVIASAKHAFDNQCIFIVVYKPRSSQFIVSYDKFLDAVNNKFNVGSRFTMRFEGDDFSERRYFGTIIGVSDFSPHWKCSEWRSLEVQWDEFASFSRPNKVSPWEIEHLVPALNVPRSSLLKNKRLREVNEFGSSSSHLLPPILTQGQEIGQLSVASPMNISLRYRDTTEAAMNPSRLLMSYPVQPMPKLNYNNQMVTQIEENITTKAGTNFRLFGVTLDTPPMIKDPIKQIGSDISKLTERKKFGQSQTLRSPIEIQSKQFSSSRTCTKVQMQGVTIGRAVDLSVLNGYDQLILELEKLFDIKGQLQTRNQWKIAFTDSDGYEMLVGDDPWPEFCKMVKKILIYSKEEVKNLKSSKSLSS
Protein: Cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose) (AA7GT) (Dg AA7GT) (EC 2.4.1.300) (Acyl-glucose-dependent anthocyanin 7-O-glucosytransferase) (Beta-glucosidase like protein) (DgBGLUL) (E3W9M3)
Organism: Delphinium grandiflorum (Siberian larkspur) (Delphinium sinense)
Function: Beta-glycosidase that catalyzes the transfer of glucose moiety to anthocyanidin 3-glucoside at the 7 position. Anthocyanins are ubiquitous colored pigments that are responsible for variations in petal color.
Subcellular location: Vacuole {ECO:0000269|PubMed:20971893}.
Interaction partners:
Sequence:
MCPSFLVTLLLLQLSSLVVVLVVWAEQLPEFNVRRDDFPSNFVFGAGTSALQVEGAIAEDGKTPNIWDVDSHMGHMPDKSTTDIACDSYHRYKEDVKIMSDIGLEAYRFSIAWTRILPYGRGFINPKGVEYYNNLIDTLLEHGIQPHATIYHIDHPQILEDEYGGWLSPRMIEDFTTYADVCFREFGDRVSHWTTINEPNIISLGAYDSGQIPPHRCTPPGAYNCTAGNSSVEPYKAMHHFLLAHASAVQIYRTKYQAKQKGLIGLNVYGFWCAPQTNSRADIEATKRATAFYTGWAADPLVFGDYPIIMKENVGSRLPSFTKNESELVKGSFDFIGLNHYFVFYIQDDPEEITTPISLRNFDSDMRVKASVKPGDSGDPSGLKNLLRYFKDNYGNPPVYVHENGFGSPQNETLDDDMGRIRYISGYIGSMLEAIKNGSDTRGYFVWSFMDAFEILSGYQTRYGIVHVDFDDKSLKRQLKPSAQWYSNFIKKKNTTEDEISYSSQ