wanglab/gogpt-training-data huggingface dataset:
Protein: PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) (O96685)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADVSLFFGGLPAILLKADTIYRIGRQKGLEISIADESMELAHATACILRRGVVRLAALVGKIFVNDQEETVVDIGMENAVAGKVKLRFGNVEARLEFGEDHDEVHDSSGFGECLKNGLNNTTLDSMDVPETQPPSANTSVNTTADSLFIPETQAVLSERPSTGQRVSLGDDFMIPETQDMLADLPPEPPVFKPPVIPVVDKPGPTIDSDEESSLGTIIRMCTQDYNEDAIDDFDTSQVLCDVLLPLPPPTAPIEGLENQDTKRDQLDTTDMEMSALNWSASNSKCCALSSTKADDILPRGDACITPDLTAPSVDRNICTPDLFDLIMGGDRRRDGSSSPDPFVRPADNTNTATPQFGGVKQLVVATIETPTATPDTNSPSSQEKNQDMIATQRFPRHKLLESDEEDNGQNNQDFVATQAFNLGRPQAPQENEANQDFIATQAFNLAPPQKVDSPKTSTANDASNQDFIETQAFNLGLPQANMASPENNEISNQDLIATQAFPAKINSSRCQDFVATQPFHVVKQHSVSLQDKENIPLDDSVKVASGTVATSPVNPNEESIQFFEPCVIKDKNHYQKICQIEGVFSNVSNRSRGRTDGTGFGRLKRVAKSESPPETPSRKDRRRSEGSERPGSNSRELLNNLVDKKSEALNKSVIREHGIDSIPEEITKEDKSDSEEKGDCFNNVVNQWRSRKRRIQSRPGTPGSSSERNEVNADVVDKPNEEPPTKNIRARKAKKAEKADSSMDIPKPTTRTRRQTIDEDARMPDLGKGKKAKNTASSKADTSKNIVKGSKRVTRQNSADDAELLEEDSSVQTESGKRVKKVKSSKGETSKDIPKAKPRTRRQTADEDAMTPKAEKERQIQGEETKDMSKPAARTRRKASAEETESAAQAVKPKRGGKGKKNETTKAEATVEKPMVRTRRMTIAEDSSTLTEVKTGGALIKRAVVRISRVSIEQLESSTSAGNNARVTGAAQSRSTTPSIEEPSSSSAAAKEPNVSTATTRRRAKRLTSGEEPTSSSDIPTKKPKMSVDEEVLKNRSSATTTRFSQPDADPLRAINLYVRKAKTTTGKIKVAFTMCNRPALETVLKSLKHVVEITEDPLQCDLLVMDKGERTYKFLTVIASNKPVLSTNWLHSVKKTRSIDIKADHLFSDPTFEETYKFKPSSVLEHPRLLYGLHFMLGKDIVPKERNESHHSQRGGKVHAQPPSLAISVDLYVVTTSKDTKSKRRLNNYEKVHFIKTEAVMQALVQHNIEMLQEHTLKL
Protein: Homologous recombination OB-fold protein (Q8N3J3)
Organism: Homo sapiens (Human)
Function: DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:31467087}. Chromosome {ECO:0000269|PubMed:31467087}. Note=Localized to the sites of DNA damage. {ECO:0000269|PubMed:31467087}.
Interaction partners:
- DNA helicase MCM8
Sequence:
MACSLQKLFAVEEEFEDEDFLSAVEDAENRFTGSLPVNAGRLRPVSSRPQETVQAQSSRLLLLHPTAPSEALGLPDLDLCLPASSTPSADSRPSCIGAAPLRPVSTSSSWIGNQRRVTVTEVLRETARPQSSALHPLLTFESQQQQVGGFEGPEQDEFDKVLASMELEEPGMELECGVSSEAIPILPAQQREGSVLAKKARVVDLSGSCQKGPVPAIHKAGIMSAQDESLDPVIQCRTPRPPLRPGAVGHLPVPTALTVPTQQLHWEVCPQRSPVQALQPLQAARGTIQSSPQNRFPCQPFQSPSSWLSGKAHLPRPRTPNSSCSTPSRTSSGLFPRIPLQPQAPVSSIGSPVGTPKGPQGALQTPIVTNHLVQLVTAASRTPQQPTHPSTRAKTRRFPGPAGILPHQQSGRSLEDIMVSAPQTPTHGALAKFQTEIVASSQASVEEDFGRGPWLTMKSTLGLDERDPSCFLCTYSIVMVLRKQAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMQGTVHRLLLETCQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSPDSGDGSFLKPSQPFPKDSGSFQHDVAAKPEEGFRTAQNLEAEASPEEELPEADDLDGLLSELPEDFFCGTSS
Protein: High mobility group protein B2 (High mobility group protein 2) (F1RJ01)
Organism: Sus scrofa (Pig)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKGEAGKKGPGRPTGSKKKSEPEDEEEEEEEEEDEDEEEEDEDEE
Protein: Keratin-associated protein 2-1 (High sulfur keratin-associated protein 2.1) (Keratin-associated protein 2.1) (Q9BYU5)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Interaction partners:
- Keratin-associated protein 11-1
- Keratin-associated protein 3-1
- Keratin-associated protein 1-3
- Keratin-associated protein 4-1
- Keratin-associated protein 3-2
- Keratin-associated protein 4-3
- Keratin-associated protein 4-8
- Keratin-associated protein 9-3
- Keratin-associated protein 4-5
- Keratin-associated protein 9-8
Sequence:
MTGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC
Protein: DNA damage checkpoint control protein MEC3 (Q02574)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Checkpoint protein RAD24
- DNA damage checkpoint protein 1
- DNA damage checkpoint control protein RAD17
- Serine/threonine-protein kinase MEC1
- Replication factor C subunit 2
- Replication factor C subunit 5
- DNA repair protein RAD9
- Replication factor C subunit 3
- Replication factor C subunit 4
- ATP-dependent helicase SGS1
Sequence:
MKLKLIVNGCEAPDDYKLLRTTINTVASLRKTAILRFNSERLTIISTPKSSLNSSNNGTILRGDTGQLWCTIPHDVFRLYTVISARELNTITMECNCDSLLSVFKRYDRVMNQGSSSNMTIKLQSMPEWNTNNGTLSGGTAGGVDTTSKPNPICALGITFEEIVHTSGPNDAIVMNGGVDEHNGLPTTVGTGNLLASNKVIMHSFKVPVKLLFRAQDTRIQEPMINYIQLMMYKLPPISGEFGSAFHGFIRRVERYSNVNHIHLMGVKKKEHGNEGDDVELKIIVNELDWHLEICWNGPLDSVIQRQEGLTDNPSQNQHIDTDGRQEEGSLPIIEADKPMSSLYTNTRDREMEENIRYDEDLLRIEDSSIADTRGNIYTADTSGDTEFNDISVMVEKAEQESSSTHEVIIRCKDWKVCSKLYAAFEEVVLAISHDESCVFHCSLDRGSLEDSEDVEKPRERGQIIYYIARSKGL
Protein: Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase family 3 member A1) (A8MYB8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Protein: Uncharacterized protein (Q57X86)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- PRP1 splicing factor N-terminal domain-containing protein
- U5 small nuclear ribonucleoprotein component, putative
- PRP8 protein homologue
- H/ACA ribonucleoprotein complex subunit 2
- Small nuclear ribonucleoprotein E
- Nop domain-containing protein
- Trans-splicing factor, putative
- Sm protein F
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MSKEKLRFVIGGKPVVYEGRPENRPKDLMDILVKLDADNNVVVQAFRDNIEGGQNTPSADILQRYSDAKRAYMEKKQKKKQSESAAAEKPVEEKPVDEKPQTMTLTFQGKQLSYQGLPSGKQHAVIELLVKHDASLEVAVETFKKNLPNSSLSGDEIWSMLVAAKEAKAARKAAKMKDAGDAGRHESRQTAEQQQQPSRPRAAAMEAIEEYTSMTLEERDSISNFIKQVLEQPDLDLSTRLRSEPGTGTGVSVPKPNTTGGVAGTDDDGLQAGSRTMRGKVAVYCQEENNTANKVLHIAPGTTFEEFTGMVEKKFGRKMAMSFYEGEDIIDMDDDDVFCMFVEMSQAQAQEGKRMKLICVPPEKRPVVADDAITEVKAETVTADTAGTTTGFKVKPFSNGRVEVRELKTYTGHTSAVYCCAFAPKGDRFCTASRDRSVRVWNTSSGTSSVMKGGHNGFVLSCDFSPRGNRVVSSSDDRTIKVWNVATCGKVYTLKGHEDKVYCVKYNSNGDYIVSCSCDHTVRVWNGNTGTKVGTYRGHTLAVFYCCFSNTDSGKYVVSGGDDRVIKVWEWERDEEQVSLDGHTDTVWSCQFSHDDTRIVSAAMNHEVRVWDWCNNSCVLSWRGHQVPIHQAMFSTSDKYIYTCARDWSVMIWDAQTGEHCETLVGHHSTVYHMDMCGNKLITSSLDDHLKLWSVNED
Protein: Zinc finger protein 469 (A0A571BDK1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
RDCHHCGKQFPKPFKLQRHLAVHSPQRVYLCPRCPQVYPEPWELKVHLGLTHGVTEEKELPHVPLYACELCANVMHVIRRSFVCSSCNYTFAKKEQFDRHMGKHLSCDLQPFTLRSVKRPGVPRRKTRVSQDVLPSKQNRLMAPFSPPELSTDRIPSTTSPTPSEVSLPALPLAPSLILDQPSSQENPVDQADHSPRGNNLPLSGQDLPPPSLSPFSAASAEGTGGCCKLNRTLEKPEHEASLGSLEPCKWQALVGEKRALHLFPGKHKSPGNGDKCAPGCSPGHPSQLQERLVTTHHMAPEGRIEGPSQKGNATKPGAYSSTSHHRAAEPTKKALKPPAPPRKPGGMGIPAAELVLSPEDRVKPNTSKGKLRGTPQSSGGLQPGTQTGGGSQPQPTSGQLQSEMASTPTEPSCPSWASSTPDQPPPRAHTKGSTRGPGDAVHQGVQVHSSPREKRESHGRQRKGQALGLGRHGSVGNTGKAPLAPDKSSRAPRKQATPSRVPPVKSRPSGQSSRARPQPSAQRKGDPGHTSEKGSLPQARALSRPYKRVRALHVSGVAPMEPRDRRTAEAQSDLLSQLFGQKLTSFRIPLKKDSSQ
Protein: Raftlin-2 (Raft-linking protein 2) (Q52LD8)
Organism: Homo sapiens (Human)
Function: Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14699}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
Interaction partners:
Sequence:
MGCGLRKLEDPDDSSPGKIFSTLKRPQVETKTEFAYEYVLLDFTLQASSNPEVIKINSILDIVTKVENYYLKGYIVGAIHPVIQPVGQRKHLPASYLYRVVLLRLKLSPKNSAAPSGQRRPRLVIEECPLTSEAQTNDAAKELIEKINVAAKRGMKFVGFISQHYSPSKFCNGTNHDGDIESMLHVRHGSDENCRSWNEGTLSGQSSESGIEEELHHESGQYQMEQNGSPTSSKSRKGEASDNKLYTVFNAFDDDSTSWAYQEGILSMKVTRKGSVISTLDADWLELTTFYYKQGLSLIDSFVFWETSKGEHLPKSLEGFFIYEEEGSGVPGSSRKGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPVLRHDSEGNLATKQIVFLQRPVMWNSAAQTPDKKASRHIKGEDKNKATSRSIGLDTTSSQPAESRHLPEECRLSPSRECWTKEGRLAQHNSFSGFSSSDNVLRELDDGQFDQEDGVTQVTCM
Protein: Cinnamoyl-CoA:phenyllactate CoA-transferase (EC 2.8.3.17) ((E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase) ((R)-phenyllactate CoA-transferase) (Q93AM1)
Organism: Clostridium sporogenes
Function: Component of the phenyllactate dehydratase complex FldABC that is involved in the fermentation of L-phenylalanine via a Stickland reaction. This complex catalyzes the reversible syn-dehydration of (R)-phenyllactate to (E)-cinnamate in two steps, a CoA-transfer from cinnamoyl-CoA to phenyllactate, catalyzed by FldA, followed by the dehydration of phenyllactyl-CoA to cinnamoyl-CoA, catalyzed by FldB and FldC. In vitro, FldA can use 3-phenylpropanoate as a better CoA-acceptor than phenyllactate.
Interaction partners:
Sequence:
MENNTNMFSGVKVIELANFIAAPAAGRFFADGGAEVIKIESPAGDPLRYTAPSEGRPLSQEENTTYDLENANKKAIVLNLKSEKGKKILHEMLAEADILLTNWRTKALVKQGLDYETLKEKYPKLVFAQITGYGEKGPDKDLPGFDYTAFFARGGVSGTLYEKGTVPPNVVPGLGDHQAGMFLAAGMAGALYKAKTTGQGDKVTVSLMHSAMYGLGIMIQAAQYKDHGLVYPINRNETPNPFIVSYKSKDDYFVQVCMPPYDVFYDRFMTALGREDLVGDERYNKIENLKDGRAKEVYSIIEQQMVTKTKDEWDNIFRDADIPFAIAQTWEDLLEDEQAWANDYLYKMKYPTGNERALVRLPVFFKEAGLPEYNQSPQIAENTVEVLKEMGYTEQEIEELEKDKDIMVRKEK
Protein: Antimicrobial peptide 1 (XT-1) (P84387)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Has very weak antimicrobial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli and stronger activity against yeast C.albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells.
Subcellular location: Secreted {ECO:0000269|PubMed:11738090}.
Interaction partners:
Sequence:
GFLGPLLKLAAKGVAKVIPHLIPSRQQ
Protein: Serine incorporator 5 (Developmentally regulated protein TPO1) (Q63175)
Organism: Rattus norvegicus (Rat)
Function: Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q86VE9}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells. {ECO:0000250|UniProtKB:Q86VE9}.
Interaction partners:
- Carbonic anhydrase 2
Sequence:
MSARCCAGQLACCCGSAGCALCCGCCPKFRQSRSTRFMYLFYFTLVIIPCCVMMSPSVMKQMTEHIPFFEDFCKGIKAGDTCENLVGYSAVYRVCFGMACFFFVFCVLTFKVNNSKSCRASIHNGFWFFKLLLLGAMCSGAFFIPDQETFLNVWRYVGAVGSFFFICIQLLLIVEFAHKWNKNWTAGTVRNKLWYASLSLALIMYSIAVGGLALMAVFYTQWDDCMDNKILLGVHGGLCVLISLAAISPCVQNRQPHSGLLQPGLISCYVTYLTFSALTSKPEKVVKDEHGKNVTICVPDFGQDFRRDESMVTWLGTLLLVVCISYSCLTSTTRSSSDALQRRYGAPELEVARCCFCFGPDGEDTEEQQNVKEGPRVIYDEKKGTVYSYSYFHFVLLLASLYVMMTLTSWFHYENATIETFFVGSWSIFWVKMASCWMCVLLYLWTLVAPLCCPSRQFSV
Protein: Aldehyde dehydrogenase 2 family member, tandem duplicate 2 (EC 1.2.1.3) (Mitochondrial aldehyde dehydrogenase 2 family) (Mitochondrial aldehyde dehydrogenase 2b) (Q6TH48)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLRTVLSRAFPQVCRISSCQHSTIPAPNVQPDVHYNKIFINNEWHDAVSKKTFPTINPATGEIICHVAEGDKADVDKAVKAARDAFKLGSPWRRMDASQRGLLLSRLADCIERDAAYLAELETLDNGKPYAVSFSVDVPMVVKCMRYYAGWADKWEGKTIPIDGNYFCYTRHEPIGVCGQIIPWNFPLLMQAWKLGPALATGNTVVMKVAEQTPLTALYIASLIKEVGFPAGVVNIVPGMGPTAGAAIASHMDVDKVAFTGSTDVGHLIQRASSASNLKKVTLELGGKSPNIILSDANMEEAVEQSHIALFFNQGQCCCAGTRTFVQESIYDEFVERSVERAKNRIVGDPFDLNTEQGPQVNEDQFKKVLGYISSGKREGAKLMCGGAPAAERGYFIQPTVFGDVKDDMTIAREEIFGPVMQILKFKSLEEVIERANDSKYGLAGAVFTQDIDKANYISHGLRAGTVWINCYNVFGVQAPFGGYKASGIGREMGEYGLENYTEVKTVTIKVPEKNS
Protein: coproporphyrinogen oxidase (EC 1.3.3.3) (C8VEZ2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Protoporphyrinogen oxidase
- Uroporphyrinogen decarboxylase
- Ferrochelatase
- Methyltransferase domain-containing protein
- Methyltransferase small domain-containing protein
- Mitochondrial hypoxia responsive domain protein
- 5-aminolevulinate synthase, mitochondrial
Sequence:
MALPRLYSAPFRRSLSRFSAPCRKPNNHQTPFHRFYSERTSQSEKSTRSSHPGKTQDKRGKKEFTVWRPYLRLAIGIPFVTLLVWDMMTGEVTQLDSPSIVEIDEALKKQASVNETSPMRLRMEKLIKDHQQKIVEELSRIDGKQFRADTWTRPNGGGGISCVLQDGNVFEKAGVNVSIVYGDLPRAAIEKMRADHKSFVGADVESLSFFAAGLSLVLHPHNPMAPTVHLNYRYFETSDPKDPINGDKNWWFGGGTDLTPSYLFPEDVQHFHKTIKEACDRHDATYYPRFKEWCDKYFYIPHRRECRGVGGIFFDDLDANFLESSSTSSQNPQETLFSFVSDALASFLPSYVPIVERRKDMPFTPAQKEWQQLRRGRYVEFNLVYDRGTSFGLRTPSARIESILMSLPRTASWAYMDPVSGTRTEHMDNEEELGEDKAHEKEMMDVLRHPRQWV
Protein: Signal peptide peptidase like 2B (A0A087WZ50)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQ
Protein: 2-(acetamidomethylene)succinate hydrolase (EC 3.5.1.29) (alpha-(N-acetylaminomethylene)succinic acid amidohydrolase) (AAMS amidohydrolase) (Q988D4)
Organism: Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Function: Catalyzes the final reaction in the degradation of vitamin B6 from (E)-2-(acetamidomethylene)succinate (E-2AMS) to produce succinic semialdehyde, acetate, ammonia and carbon dioxide.
Interaction partners:
Sequence:
MDMAADIASDHFISRRVDIGRITLNVREKGSGPLMLFFHGITSNSAVFEPLMIRLSDRFTTIAVDQRGHGLSDKPETGYEANDYADDIAGLIRTLARGHAILVGHSLGARNSVTAAAKYPDLVRSVVAIDFTPYIETEALDALEARVNAGSQLFEDIKAVEAYLAGRYPNIPADAIRIRAESGYQPVDGGLRPLASSAAMAQTARGLRSDLVPAYRDVTKPVLIVRGESSKLVSAAALAKTSRLRPDLPVVVVPGADHYVNEVSPEITLKAITNFIDA
Protein: Transcription factor-like protein DPA (DP-like protein A) (AtDPbA) (E2F dimerization partner protein A) (AtDP2a) (Q9FNY3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11891240}. Nucleus {ECO:0000269|PubMed:11891240}. Note=Interaction with E2F stimulates the nuclear translocation.
Interaction partners:
- Transcription factor E2FB
- Transcription factor E2FC
- Retinoblastoma-related protein 1
- Transcription factor E2FA
- Protein ALWAYS EARLY 3
- Protein ALWAYS EARLY 1
- Protein ALWAYS EARLY 2
- Histone-binding protein MSI1
- Transcription factor-like protein DPB
- Transcription factor MYB3R-3
Sequence:
MSMEMELFVTPEKQRQHPSVSVEKTPVRRKLIVDDDSEIGSEKKGQSRTSGGGLRQFSVMVCQKLEAKKITTYKEVADEIISDFATIKQNAEKPLNENEYNEKNIRRRVYDALNVFMALDIIARDKKEIRWKGLPITCKKDVEEVKMDRNKVMSSVQKKAAFLKELREKVSSLESLMSRNQEMVVKTQGPAEGFTLPFILLETNPHAVVEIEISEDMQLVHLDFNSTPFSVHDDAYILKLMQEQKQEQNRVSSSSSTHHQSQHSSAHSSSSSCIASGTSGPVCWNSGSIDTR
Protein: Lmo1959 protein (Q8Y5U6)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
- FhuC protein
- FhuB protein
- FhuG protein
- Lmo2429 protein
- Lmo2182 protein
- Probable heme-iron transport system permease protein IsdF
- Lmo2430 protein
Sequence:
MKKGIILLVSMLFIAVVLTACGDNKSAGSEQVEMRTYTMANGKKVEIPAHPKRIVASEYLGNIVLLGMKPVGARAKQMENPFLKGKVDGIADIGDPVSAEKVAELKPDLIIVSNDDEFEAMSKIAPTVLIPYATSKNVEEDVRQIADLVGEKKAGEAWLDKFHQKAKESRAKLAGKLDPNETVGIYEVQDKDFYVMGQNMGRGGQAIYNALQLKAPAKIQKDVLDGQDWQKISLEVLPEFAADRMFVTTTSSGNAKDGEETLKDLTNSPIWKDLPTFKAGNVYQMDFDTMFYYDPLAVEGQLDIIVEKLLASN
Protein: CCT motif family protein (Q8L602)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00357}.
Interaction partners:
Sequence:
MYQDSGLMLRYMQNCPPDIQQFEDLFKSYKLSDEMNNTFVESSNISEYDIGEESDLFRAPDPILEEPILTVDPLSAALTMISCGEDTSQGLCELPDLGSLQSGQQLLDKAFYECEQDLMMKSAMESPFSDVLDIKNISVVTTINENQDMQKSVSSGNLSSMDWSHAQQETVMIQNFPDFDFGYGMRRAFSEGDIQKLGAGLVQSPLDRIIVSCTSEDRREKLSRYKNKKSRRNFGRKIKYACRKALADSQPRVRGRFAKTEERK
Protein: Kinesin-like protein (F1QDF0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
- Rac GTPase-activating protein 1
- Kinesin family member 11
- Serine/threonine-protein kinase PLK
- Kinesin-like protein
- Kinesin family member 15
- Aurora kinase A
- Kinesin-like protein
- Centromere-associated protein E
- Protein regulator of cytokinesis 1b.
- Uncharacterized protein.
Sequence:
MALASPCGILSDEEECGAVFESTAADVVGLMRSQRFVSPLPEISVITPAADSLTPTKELVQIKSDISRRGSTDDGSDKLKVFLRIRPLTEAEKDRGEEQGCVNVQSEDNLLLKAPKDSRNMKSAERGVAQSVHKFTFTKIFGPQTSQQEVYDHTIREMVRDVLRGENRLLYTYGVTNSGKTYTIQGAGAEAGLLPRALVSVFLKLSGRLYTAMDLKPVLSQEVRKLDVGEVRAEEMRRDALLKEDESNQSRLRAGLSWDSGISGLSATSHIATQLEDSDGVCLEANGLCLSGGEDLEEGVQFSVWVSFYEIYNEFLYDLLDAPPSLQSRKRVTLRLSDDKHGNPYVKDLTWIQVHSAEEAWKVLKVGQRNQSFASTHLNHNSSRSHSIFTIRVLHVKPQLGQVTRISELSVCDLAGSERCKAQQNGERMKEANNINTSLLTLGRCITALRHNQTNKSRPPVVVPFRDSKLTRVLQSFFCGHGRSCMVVNINPCASTYDETLQALKFSAIATQLVHGPCSKTRVAYILSLLREQPTHPNDTTLLEEDEEESDEEGDITMFDPEALLKAIDVLKREVLRQRQEKEELEAKVREEVCTEMMEVISRMQDDFSETLESERDLMEKRCENKINNLKSSLKKYYSQELEERDDEIRELTAALKEKEAGNTAPAAIFPPLNDDGGLRRSQRLASTHKRDADHESIELFRCKAELENCRAELDLKQTELRLKTLELKRFQDNLPSMGVTGTLTTTAERKLEEGQRNLKQLRMELQLLGIKLQSGERACCRNTDGEKLRHALSSADSKLAKQDQMLVELHTSLQLVKAELRKKDELLTRFQNTQQAQSHQPPTASGSCKKRGCGVAVALAENQPPEKRPFFRSLFPSRTPSKTPSRPTRQQNEVTTPYSRVLRSRQPSPPTTPVMLRVKY
Protein: Polyubiquitin-C (E9Q5F6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQ
Protein: Ethylene-responsive transcription factor ERF088 (Q3E703)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor bHLH126
- Zinc finger CCCH domain-containing protein 15
Sequence:
MLKSSNKRKSKEEKKLQEGKYLGVRRRPWGRYAAEIRNPFTKERHWLGTFDTAEEAAFAYDVAARSISGSLATTNFFYTENTSLERHPQQSLEPHMTWGSSSLCLLQDQPFENNHFVADPISSSFSQKQESSTNLTNTFSHCYNDGDHVGQSKEISLPNDMSNSLFGHQDKVGEHDNADHMKFGSVLSDEPLCFEYDYIGNYLQSFLKDVNDDAPQFLM
Protein: 26S proteasome regulatory subunit 4 homolog (Protein mts2) (P36612)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Probable 26S proteasome subunit rpt4
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit 8 homolog
- Ubiquitin carboxyl-terminal hydrolase 6
- 26S proteasome regulatory subunit rpn501
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn7
- 26S proteasome regulatory subunit rpn502
Sequence:
MGQAQSGNFSNFGDGANGDNKKDQKKDKPKYEPPVPTRTGRRKKKAQSGPDASAKLPTVIPTTRCRLRLLKMQRIHDHLLMEEEYVQNQERLKPQDERTQEERNRVDEIRGTPMSVGTLEEIIDDDHAIVSTAGPEYYVSIMSFVDKDMLEPGCSVLLHHKAMSIVGLLLDDTDPMINVMKLDKAPTESYADIGGLESQIQEIKEAVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPRLVRQLFNAAEEHSPSIVFIDEIDAIGTKRYDAQSGAEREIQRTMLELLNQLDGFDTSQRDIKVIMATNRISDLDPALIRPGRIDRKILFENPDEATKRKIFTIHTSKMNLGEDVNLEELIQCKDDLSGAEIKAIVSEAGLLALRERRMRVVMDDFRQAREKVLKTKDEGGPAGGLYI
Protein: C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53] (P55207)
Organism: Rattus norvegicus (Rat)
Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Atrial natriuretic peptide receptor 2
- Atrial natriuretic peptide receptor 3
- Natriuretic peptides A
- Atrial natriuretic peptide receptor 1
- Natriuretic peptides B
- Guanylyl cyclase C
Sequence:
MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELAEPQAAGGNQKKGDKTPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC
Protein: Extra-large G-like protein, putative (DUF3133) (Q9M371)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MADSTKVRLVRCPKCENLLSEPEDSPFFQCGGCFTVLRAKTKEREADSVSVKSVEDTAKPVSASSPEKAILDSSETSSDSDVPSLRHHHNVVPVDVESDPCSKPSSLEQGNRSILLGDKDDLKSQSGRQQDSGWDRFRKRTTKRCDSQSVINRLSTSRHPCDEGTSSSANYFPDSLLEFQKHLKDQSNEAIEQDRAGLLRQLEKIKEQLVQSCNVATDKSKEQAPSSSSASGLNKAPPMRFHSTGNHAVGGPSYYHQPQFPYNNNNINEAPMHHSLMHPSYGDPHRFPIHGRGPHPYFSGQYVGNNNNGHDLFDAYPQQNGHFHHSSCSCYHCYDNKYWRGSAPVVPDAPYNAGFYPHESVMGFAPPHNPRTYGSRGLQPHGRWPSNFSDAQMDALSRIRPPKVVLSGGSRHIRPLAGGAPFITCQNCFELLQLPKKPEAGTKKQQKVRCGACSCLIDLSVVNNKFVLSTNTASTRQGEARVAADYTSDDYDLLGYVFHSLDDEPRDLPGLISDKSQDMQHVHSHSASLSEGELSSDSLTAKPLAEAHENFVDYSSINHDRSGAGSRSSRSEHDKVTLSKATAMRQNSMKEVSLASEMEVNFNDYSHRNSGVSKDQQQRAKKSGFASIVKKSFKDLTKSIQNDEGNKSNVSINGHPLTERLLRKAEKQAGVIQPGNYWYDYRAGFWGVMGGPGLGILPPFIEELNYPMPENCSGGTTGVFVNGRELHRKDLDLLAGRGLPPDRDRSYIVDITGRVIDEDTGEELDCLGKLAPTIEKLKRGFGMRLPKRTT
Protein: Transcription factor TCP11 (Q9SJK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TCP1
- Transcription factor TCP3
Sequence:
MIFQNVCRNESNFNAIASESRSQTQFGVSKSSSSGGGCISARTKDRHTKVNGRSRRVTMPALAAARIFQLTRELGHKTEGETIEWLLSQAEPSIIAATGYGTKLISNWVDVAADDSSSSSSMTSPQTQTQTPQSPSCRLDLCQPIGIQYPVNGYSHMPFTAMLLEPMTTTAESEVEIAEEEERRRRHH