wanglab/gogpt-training-data huggingface dataset:
Protein: PUB domain-containing protein (Q38BF0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- UBX domain-containing protein
- MPN domain-containing protein
- UBX domain-containing protein
Sequence:
MTDRNGEHDVSTRDCQSDSEHSDSEKRKYYISQSLFESLQAKGFSENAIKKSIVAGCVDEGTCTQWITMHEDHPELNTPLEEGVEVVVRVKRVLTEAEREAKVQELRGKARAKMEEEKRQALEDERKRVSMGRKAIEVKEELDKIRREAELEAVRKQKQQDLAARRRVRIQILTDKFIREGSMPEEARRKAEEEIEEEARKKREQALAQVDMEQWQHGTSQTGTAPTVWNLQSLAAPPPVSLDEVFTNEPPMAASSLPELAAAVANFNDAVTAQQCLKMLRTILTNIRDNPFDTSKRLLKTSTNAFCTKLAPVRPALQLLRVCGFRLGVDFGGNEVITATTMVVRVVNRALAALSSYP
Protein: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (D3ZS72)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- small monomeric GTPase
- Ras-related C3 botulinum toxin substrate 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Guanine nucleotide-binding protein G
Sequence:
MEAPGSGSGDGGGDPGGDGAHPDARGPSSGPCAAARDSERQLRLRLCVLNEILATERDYVGTLRFLQSAFLQRIRQNVADSVDKGLTEENVKILFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAARAFLLNCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELSKRTPGKHPDHSAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKVGRLLAACGAHPAGGPCSLDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETILNQSFCSRRPLRLLVATKAKETIKIPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGLCAGQCILKVNGNSVANDGALEVLEHFQAFRSRREEALGLYQWVYHSHEDAQQARASQGAPDEDPQEDDSVLPLLSLGPQLSLHEDSAVVSLTLDNVHLEHGVVYEYVSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAEDDSLFVQNCGRLMAMGSAIITMSHYEFHNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEDHPLCGLDFCPTNCHINFMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMAYTQHCITTMAAPSWKCAPAVDGDSQSQGLIDSIFVSASGALSQQERGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSAAPCDPPLVEETSSSPPASEESEVDRTDHGGIKKVCFKVSEDEQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDETGSGDELPCDIRIPSDKQDKLHGCLEHLFNQVDSIHALLKGPVMSRAFEETRHFPMEHSWQEFKQKEECTVRGRNLIQISIQEDPWNLPSSIRTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVAAVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENSVANTNVFYHIEGSRQALKVVFYLDGFHFSRLPSRLEGGASLRLHTVLFTKALENVEGPSPPGSQAAEDLQQEINAQSLEKVQQYYRRLRAFYLERSNLPTDATTTAVKIDQLIRPINALDELYRLMKSFVHPKAGAGGSLGAGLVPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQGPRVEILAKNLRIKDPMPQGAPR
Protein: Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) (Q38B23)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- ADP-ribosylation factor 3, putative
- ADP-ribosylation factor, putative
- ADP-ribosylation factor-like protein 3
Sequence:
MDERGILESILQFTHSPMWRTPVDNFIDERCALFTDDEEMKVEQTEVHMQFRKITDDILSKYVKELGITLEDALNAVVNSMDTASQTNRLGKKFMQEIFYIEDFPTFHKMMVRRNIELDILAQCEISQKRENSGAKTANDEEEAMRLAIEASLNDEEKTRRLMELEDLQLQEALALSIAAEHERARNTFEKISQEAVEEAKVVGKAAAEETKLKKLTAAEEEKEKTIVKLEERALEVRQQAMLQRLTATMVVEPTPVAPKKEAPAPAPAKAPAESKPAATAAKAPTAPPAVPPGPLSRGRPIMPSLHTDHGADSGKKFGFSKLPTHQPSFKQLEATMAKGIAGASSAGGGAAGAGAASSKVEDEELARRAEHMRKQRELILQKNRETREEELRNYMNTKTTNPADSSVGRVERQMTLDLAQRLRNDILDETKK
Protein: Transcriptional regulator (Q8P9D2)
Organism: Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Interaction partners:
- RNA polymerase sigma-54 factor
- RNA polymerase sigma-54 factor
- Flagellar hook-basal body complex protein FliE
- Flagellin
- Flagellar motor switch protein FliM
- Flagellar secretion chaperone FliS
- Response regulator
- Flagellar biosynthesis switch protein
- RNA polymerase sigma factor FliA
- Flagellar biosynthesis protein FlhF
Sequence:
MSESRILLIDSDAVRAERTVSLLEFMDFNPRWVTDGADINPGRHRHDEWMAVMVGSAQDAAQADKFFDWLADAKLPPPVLLMEGSPSAFAQAHGLHEANVWALDTPLRHAQLEALLRRASLKRLDAEHQAGVQQDTGPTGNSEAVTRLRRLIDQVAAFDTTVLVLGESGTGKEVVARAIHQHSPRRDGPFVAINCGAIPPDLLESELFGHEKGAFTGALTTRKGRFEMAEGGTLLLDEIGDMSLPMQVKLLRVLQERSFERVGGGQTIRCNVRVIAATHRNLETRISDGQFREDLFYRLNVFPIEMPALRERVDDLAILVQTIAGQLARTGRGEVRFADEALQALRSYDWPGNVRELTNLVERLAVLHPGGLVRVQDLPARYRGDFASSIPVELPPEPALVAPHGEVAALPSNVVTLQPATAHADAEPLTASSLPDDGIDLRGHMANIELALINEALERTQGVVAHAAQLLGLRRTTLVEKLRKYGIDREQTELAN
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (Q9V4E5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Ephrin
- Roundabout 1, isoform A
- Roundabout 2, isoform B
- LP22668p
- Cdc42 homolog
- Plexin A, isoform A
- LD30122p
- Netrin-B
- Netrin receptor unc-5
- Plexin-B
Sequence:
MKMVGCHPNDKKVKYDGIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQLDTII
Protein: PIN domain-containing protein (Q4GZ37)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDNSTELGPLNSPGNIFTSHGEGNSIGTSSPPHPHSTESTGDNNEFMNPHNIVSSHMPSREGSVFVNRHPPERPVETLEKDDQNRSYLYSPAPTTDCNESVNFVCMQEAAAAGLQTPIVPAASSSISQHTAAESKSVHSTENNNDFVKVFTTSKGSHKGGRLEALRRISNKHKTFIGLTTITPQQRNTNDCINRSINASAPNELSRAGDNGAVTNPGGTKLVHSVPVKQLQPQVSHIVLDTCSLLRVGPLQLACLMRRAVVCLPHGVLHEMDSWNHVAKKYEDEISRKRAFVARRIRTWVHYATKYKASIRLQAMNEVNTAFDKHVQRNDMAILGFAVFLERNEKTLVEFVTDDTYLSLTAAQELKGVVRTTKGLLDYYGC
Protein: N-((2S)-2-amino-2-carboxyethyl)-L-glutamate dehydrogenase (EC 1.5.1.51) (Staphyloferrin B biosynthesis protein SbnB) (Q2G1N2)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Catalyzes the hydrolysis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) to form L-2,3-diaminopropionic acid and 2-oxoglutarate. Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
Interaction partners:
- N-
- L-2,3-diaminopropanoate--citrate ligase
- 2-[
- Staphyloferrin B synthase
- 2-[
- ATP-dependent L-serine kinase SbnI
- Staphyloferrin B transporter
- proline dehydrogenase
- Pyrroline-5-carboxylate reductase
- Arginase
Sequence:
MNREMLYLNRSDIEQAGGNHSQVYVDALTEALTAHAHNDFVQPLKPYLRQDPENGHIADRIIAMPSHIGGEHAISGIKWIGSKHDNPSKRNMERASGVIILNDPETNYPIAVMEASLISSMRTAAVSVIAAKHLAKKGFKDLTIIGCGLIGDKQLQSMLEQFDHIERVFVYDQFSEACARFVDRWQQQRPEINFIATENAKEAVSNGEVVITCTVTDQPYIEYDWLQKGAFISNISIMDVHKEVFIKADKVVVDDWSQCNREKKTINQLVLEGKFSKEALHAELGQLVTGDIPGREDDDEIILLNPMGMAIEDISSAYFIYQQAQQQNIGTTLNLY
Protein: Acyl-CoA dehydrogenase (O33331)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQMLDGERAKREKRDSSGSFGLADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHVTRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDNVRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQNMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA
Protein: PRKC apoptosis WT1 regulator protein (Q93231)
Organism: Caenorhabditis elegans
Interaction partners:
- Putative dihydrofolate reductase
- Probable phosphomannomutase
- Putative folylpolyglutamate synthase
- Ubiquitin conjugation factor E4 ufd-2
- riboflavin kinase
- Probable delta-1-pyrroline-5-carboxylate synthase
- GTP cyclohydrolase 1
Sequence:
MTALREARGDSSSADPINGTRGKANINERKFAFLNQVTRPDYRSLPTSAATSQSSVPSTPVSVPMRINGNVDQIMFREFGAPIATPEDEEQLLDDLEIKSAPLLSPRRTFADFEDRSSEEKENRRIEEDDDTEADTTIREEFDYEKEEEVLKEEKIIDKPNVETVEEHKENKNESPDFIRMVESAPELTTSFDEKEETNYNKSPEQEIEAEEIRKMTESFGEPRKAVLERVTVEETDDEETETETETENEEMDEKDVYDDVRRQIAAVSDNPMVFGWNAKSNKEQLEKPTSLPLHYELEADCSTPRRAEFSMNPEDDYENQSEDATPATSSGEEGVLQQSLLQLQKQLRKTDVRCSRLEKICEFQQRDIDSLRFEVDWKDKRIEFLQKTLQEIETSTSQSDAPNTSRSTTTSTS
Protein: DNA replication licensing factor MCM3 (EC 3.6.4.12) (F1NFJ0)
Organism: Gallus gallus (Chicken)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368061}.
Interaction partners:
Sequence:
MAAPAGGLDDAELREAQRDYLDFLDDEEDQGVYHGKVRDMISDNQYRLLVNINDLRRRNEKRANRLLSNAFEELIAFQRALKDFVASVDATYAKQYEDFYIGLEGSFGSKHVSPRTLTACFLSCIVCVEGIVTKCSLIRPKVVRSVHYCPATKKTIERRYTDLTSLDAFPSSTVYPTKDEENNPLETEYGLSVYKDHQTISIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGGYTSGTFRTILIACHIKQMSKDARPLYSANDVAKIKRFSKSRSKDIFNQLARSLAPSIHGHEFIKKALLCMLLGGVEKVLENGSRIRGDINILLIGDPSVAKSQLLRYVLGTAPRAVGTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTIAKAGIHARLNSRCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDSEQDREISDHVLRMHRYRNPNEQDGDAMPLGSAVEILATDDPDFAQEEEQELQVYEKHDDLLHGPNRRKEKIVSMEFMRKYIHVAKMIKPVLTQESADYIAEEYSSLRSQNQMNSDIARTSPVTARTLETLIRLSTAHAKARMSKTVDLQDAEAALELVQFAYFKKVLEKEKKRKKQVEDDSETEKEEEEEETQPEKEGRKQRRKKARTEGEEESYDPYDFSDAEQEMPEVQAHTPKTPESSATGEAKKPELADPRLKAFKAALLEVFKSSHAQSVGLKNVMESINRDNPEPFSLAEVKVALAHMQDDNQIMVSDDIIFLI
Protein: Cytochrome b5 reductase like (H0YDY7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
RGPESQSCPSKLNPETFVAFCIIAMDRLTKDTYRVRFALPGNSQLGLRPGQHLILRYTQCYQMGLMSRYVESWRVGDTAFWRGPFGDFFYKPNQYGELLLLAAGTGLAPMVPILQSITDNENDETFVTLVGCFKTFESIYLKTFLQEQARFWNVRTFFVLSQLVESTNVEPMDTEG
Protein: Arabinogalactan protein 2 (Fasciclin-like arabinogalactan protein 1) (A9XTK6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MRQQYVFTTLTLLILFSLSCSTTLAQSPALAPAPSGPTNVTKILEKAGQFTLFIRLLKSTQVANQLLGQLNNSNNGMTVFAPTDNAFSSLKSGTLNSLTDEQKVQLVQFHIVPTYLTSSQFQTISNPLRTQAGDSGDGKFPLNVTTSGNSVNITTGLTNTSVSGTIYTDGQLAVYQIDQVLQPLQIFAPRPPAPAPAPAKSKNKKATTVADSPDVTPADNSKAATLQNVGLFGVAALVIALSL
Protein: Probable diacylglycerol kinase 3 (DAG kinase 3) (EC 2.7.1.107) (Diglyceride kinase 3) (DGK-3) (Q03603)
Organism: Caenorhabditis elegans
Function: Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
- Phosphatidate cytidylyltransferase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
- Putative diacylglycerol kinase K06A1.6
- Phosphoinositide phospholipase C
- Diacylglycerol kinase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
- Phospholipase
- LNS2/PITP domain-containing protein
- O-acyltransferase
Sequence:
MLLSPEQFSRLSEYAAYSRRKLKDMLSDFQQDGKFYSYLSVDGQTINIDGFRAFLIDYFGADLPSDLVDQLFLSFSKPPIKERRTSLFEDAISTVRAKFSESLSGRMAGLNIAGGSGQQTDRSQSSEPQALVCIPEDDVMGPRVANNDSQEPRIPLKPLICTLSLLEADTPENKLDVVFHVYDSDGNGFLDKSEIDGIIEQMMNVARYQQWDTIELEQVIRQMMVDIDYDNDGIVSFDEWRRGGLTNIPLLVLLGFDTEMKEDGSHVWRLRHFTKPTYCNACCSILVGWGGKQGLSCSLCKYTVHERCVRSAATNCIRTYSSRQQDKLYHHWQDANATAKCVKCKATVGVFQGKGCRWCHNYVHHRCMSALAQECDLGALVHHILPPTHIFPAFLERKTSTSLKNHNFSSHSASLLQAVSPSNDCRPLLVLVNPKSGGKQGVKILQKFEYLLNPRQVYDLSKTGPEPGLQLFSTLKNCNILVCGGDGTIGWVLESMDKMTFPHGRPPVAVLPLGTGNDLARCLRWGGGYENENLHKILEQIEKSSLIDMDRWQIKIEITENKSARRASEKGDTPPYSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKLWYFELGTSETLSSSCKNLHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWGRSRKSKGRMPGLFPMKNAEKMQLQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGARRLSQCSTVVIQTHKSFPMQIDGEPWMQPPCIIQITHKNQAKMLVAAAPRKRSSWMLLKRQSTNDDN
Protein: Probable ornithine aminotransferase (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase) (Q54JP5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Bifunctional protein argC
- Arginase/agmatinase/formiminoglutamase family protein
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Probable ornithine decarboxylase
- Arginine biosynthesis bifunctional protein ArgJ
- Uncharacterized cyclodeaminase
- Proline dehydrogenase 1, mitochondrial
- Acetylglutamate kinase
- Glutamate dehydrogenase, mitochondrial
- Multifunctional protein pyr1-3
Sequence:
MDPISSQIQECTSKELIEMESEFAAHTYHPIPVVFKKASGVHVWDVEEKQYFDFLSAYSAVNQGHSHPKIVSALITQAQKCALSSRAFYNEVFPQYAKYITEYFGYEMVLPMNTGAEAVETSIKLARRWGYVKKGIAEDQAIVISCKGCFHGRTIGVISMSDDPSSYNKYGPLMNGIIKIDYNSTQQLEEVLSQHADRVCGFIVEPIQGEAGVVVPDEGYLKKCYELCKKYNVLLVADEIQTGLCRTGRMLCSDWDGIKPDLVLLGKAISGGLLPISAVLGGKDVMLTIKPGEHGSTYGGSPLASAVAMAALDVLRDENLAENAQKLGEHFRAQISNINHPAIQLVRGKGLLNAIVIDPNFTVSAWDICIKFAENGLLAKPTHDNIIRLAPPLTITLEQIDQCVSIIKKVFDSFKN
Protein: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1) (P52899)
Organism: Caenorhabditis elegans
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein
- Dihydrolipoyl dehydrogenase, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Pyruvate kinase
- 2-oxoglutarate dehydrogenase, mitochondrial
- Pyruvate carboxylase 1
- Malic enzyme
- Pyruvate kinase
Sequence:
MSLFARQLQSLTASGIRTQQVRLASTEVSFHTKPCKLHKLDNGPNTSVTLNREDALKYYRDMQVIRRMESAAGNLYKEKKIRGFCHLYSGQEACAVGMKAAMTEGDAVITAYRCHGWTWLLGATVTEVLAELTGRVAGNVHGKGGSMHMYTKNFYGGNGIVGAQQPLGAGVALAMKYREQKNVCVTLYGDGAANQGQLFEATNMAKLWDLPVLFVCENNGFGMGTTAERSSASTEYYTRGDYVPGIWVDGMDILAVREATKWAKEYCDSGKGPLMMEMATYRYHGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDRIITSSLATEEELKAIDKEVRKEVDEALKIATSDGVLPPEALYADIYHNTPAQEIRGATIDETIVQPFKTSADVLKSIGRA
Protein: UDP-N-acetylglucosamine transferase subunit alg14 (Asparagine-linked glycosylation protein 14) (O14199)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit alg13 to the ER (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- UDP-N-acetylglucosamine transferase subunit alg13
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- GDP-Man:Man
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Probable Dol-P-Man:Man
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Uncharacterized protein C16E9.19
- Uncharacterized protein C553.06
- Dolichyl-phosphate beta-glucosyltransferase
Sequence:
MNTYVLTAIAVLASLIILLVGRNAIKSSKKKPFQKHLLVFFGSGGHTGEMLNLLNALDDKLYSVRSYVAGSDDTMSVSKASLLSNSLPSVKSKIFKVPRARYVKQSWLTTPFTAFWSLLGSISVIFWNPFGIPDVILCNGPGTCVFICLLGYLAKFLGKNVKIVYVESFARVKSLSLSGKILMPFVDRFLVQWPDLATKYKRAEYIGIVA
Protein: S-adenosylmethionine synthase 2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (P19358)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Interaction partners:
- S-adenosylmethionine synthase 1
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Homocysteine S-methyltransferase 2
- Homocysteine S-methyltransferase 1
- S-adenosylmethionine decarboxylase proenzyme
- Adenosylhomocysteinase
- Aromatic/aminoadipate aminotransferase 1
- Free methionine-R-sulfoxide reductase
- Methylenetetrahydrofolate reductase 2
- Cystathionine beta-synthase
Sequence:
MSKSKTFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRIDTVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF
Protein: RING/leucine zipper protein (Q94491)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MDPLEEDFAFKYFTKGAPIKVESVLNFDLKEHLKSPYLWTTIVAGLGLAYYFLTSDDEIGIGPAGAFENNNAENGVDNFNQYNYINQDVIPPPQQQQQQQQQQQQQQNNHIHHNHNHSHNNNNHHNHVQQTTTTTTTTTTTSSSFLPITPPPPSNVQHVKLKNKNGEPLPLEEQNLLLLRENSNLRGENRDLRVWVGNQINNINDRMEKMQTDLEREKFCHICEENEKQVCWRECGHRLCARCATLIKKTSHPQCSICRKLVSDFYLAWNT
Protein: Uncharacterized membrane protein YLR326W (Q06170)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Methylthioribose-1-phosphate isomerase
- Uncharacterized protein YML108W
- Cytoplasmic export protein 1
Sequence:
MSGFIKSTLLGLGQDYLEDQYQEFAEQHFQPTRDPFYETNKDGKKHRRRLPYYCTKDESKAWKKVQNKAWLHDKSLCGCCCWTNTIGWAPLLALLPVIGPLLMYWVHDKLIELADDRYKLPAEIKVKMHGNIVIDLLISLVPILGSVFAWLHACSTRNAAIVYNFVGKRALERKQAELMHQKEENEKHSNANTAPPVVGGNKNVNGNRNNSKMYNRPPVTAPPAPAYTRSTNGRPQRGYR
Protein: MIO-dependent tyrosine 2,3-aminomutase (EC 5.4.3.6) (Tyrosine ammonia-lyase) (EC 4.3.1.23) (Q8GMG0)
Organism: Streptomyces globisporus
Function: Involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. Catalyzes the MIO-dependent deamination of L-tyrosine generating the corresponding alpha,beta-unsaturated acid, (S)-beta-tyrosine.
Interaction partners:
Sequence:
MALTQVETEIVPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIYGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGASGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
Protein: WASH complex subunit 1 (Protein washout) (WAS protein family homolog 1) (Q7JW27)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. Participates in both linear- and branched-actin networks. Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis. Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber. During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migration of tail hemocytes anteriorly along the ventral midline. Its function in hemocyte transmigration is independent of the WASH complex. May play a role in endosomal sorting; its assembly in the WASH complex may regulate its nucleation-promoting factor (NPF) activity.
Interaction partners:
- WASH complex subunit 3
- WASH complex subunit 2
- WASH complex subunit homolog 5
- WASH complex subunit 4
- Protein cappuccino
- WHAMM and JMY related, isoform B
- Wiskott-Aldrich syndrome protein family member
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
Sequence:
MEESPYLHSPYQVAIIATDLHHEDTIIQAAQSLDCLHKTINSIFERIDARLARNGSKVEDINNRVKRAQAKIDALVGSKRAIQIFAPARFPASDVLAPLPATFPQVAANPLMEQQVDQLPQGTYSSHSAADQKPDDADIFFHVRGDREQESPLVAERKITNRTAGLGILPAGGVRSVPSLMRFNTNEFAYGEDLNAWKRSLPPQNARRVASQSTQLTGEKQLAPAPHSLAHGTTKLATPAGDLRYNPAALAAPAIDVPLDLPDLPGIANDLQYEPVEEQTPIAPSQQFGDLPELPDLGLEEQDIIVQAIAAQTHIPGPVRRKSVGQCPSPVTAAPPPPPPPPPPPPPPPPAQTSAIPSPPPFPTKGAVKPLSPSLATPLNMPQPPPATEDPRSELMAAIRNAGGVHGGRLRSPAAAPLDVVDNSRSKAGGAVTGDLMADLHNKLMLRRKGISGSQNPVEATAGNPLMQQLSRVIPPPVQPRKGSKSSDEHSEDDEDGWN
Protein: FI01127p (Visual system homeobox 1, isoform A) (Visual system homeobox 1, isoform B) (Q9W4B2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Protein Optix
Sequence:
MQATKMRTPFAIQEILGLGAYQQQATASATPSEAPPSPAATPPPTANTPANGSLSAVQQQQQQQQQQQQQQQQLQQQQQQAIDSLRESRSISPDVSRLSAAAAAAAAAAAHCQLPVFNPANFYAAAGYAAAADPGNAAAAHHHHMTTLAAAAYLRGFLPPGFSTPHEFRGHFQQHFGAQFAEQAAARGQEYASSLANASGDEQSPSKNSSSSGNGGSGGSGSGSGGGNPTSNGLGHLGSPTASNGGSGGGAGVGGSGGGSGTSGSNSSTSGNGGNGGSSGSRSSPAGPHHSAALAAHQHAAAAAAAAHHHAAAAAAAHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAHHAEAFLGAAGGAGGNPNSLLAAHGGDVLVGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKSAKEDESVAPWLLGMHKKSLEAAELLKSDESDRETPTSDDTNTSYSAGSTHNSPISSFSISRLLFDAPPPAAGSAGGKGHHHHHHHHKGHHHAHVHAQAQAHAHMLLHHQQQQQQQQQQQQHHHHLHAAENSLQQQQVAGTGSGSGSGSGSGTGAGSTGPPAHHPYNQQQHLHHLQQLQQQQQQQQQQAQQQQQHHHHQHHHSVHHMHHHNAAAGYAEAAVAAAAAAAAVAAAANARNAAAAAAVAAASASASAAVTIAESEAEEEQDDIEDMELDKDCEVEEDVEPVDNDTNTNNEHDNECDADADVEADVDADADADPEIDICDDHDEEMRLQEQLLLKVKQEQAHLGSR
Protein: POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1) (Octamer-binding protein 8) (Oct-8) (Octamer-binding transcription factor 8) (OTF-8) (P20264)
Organism: Homo sapiens (Human)
Function: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:31303265}.
Interaction partners:
- Achaete-scute homolog 1
- Condensin complex subunit 3
- Histone-lysine N-methyltransferase EZH2
- Myelin transcription factor 1-like protein
- Structural maintenance of chromosomes protein 4
- Condensin complex subunit 2
- Delta-like protein 1
Sequence:
MATAASNPYLPGNSLLAAGSIVHSDAAGAGGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ