wanglab/gogpt-training-data huggingface dataset:
Protein: Citrate synthase, mitochondrial (EC 2.3.3.1) (P00890)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Specific citrate synthase with catalytic activity only with acetyl-CoA.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11502169}.
Interaction partners:
- Aconitate hydratase, mitochondrial
- Citrate synthase 3, mitochondrial
- Malate dehydrogenase, mitochondrial
- Citrate synthase, peroxisomal
- Acetyl-coenzyme A synthetase 1
- Malate synthase 1
- Malate dehydrogenase, peroxisomal
- Malate dehydrogenase, cytoplasmic
- Acetyl-coenzyme A synthetase 2
- Fumarate hydratase, mitochondrial
Sequence:
MSAILSTTSKSFLSRGSTRQCQNMQKALFALLNARHYSSASEQTLKERFAEIIPAKAEEIKKFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPEEGIRFRGRTIPEIQRELPKAEGSTEPLPEALFWLLLTGEIPTDAQVKALSADLAARSEIPEHVIQLLDSLPKDLHPMAQFSIAVTALESESKFAKAYAQGVSKKEYWSYTFEDSLDLLGKLPVIASKIYRNVFKDGKITSTDPNADYGKNLAQLLGYENKDFIDLMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGRANQEVLEWLFKLREEVKGDYSKETIEKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVARAIGVLPQLIIDRAVGAPIERPKSFSTEKYKELVKKIESKN
Protein: Centrosomal protein 20 (FGFR1OP N-terminal-like protein) (FOP-related protein of 20 kDa) (LisH domain-containing protein FOPNL) (Q9CZS3)
Organism: Mus musculus (Mouse)
Function: Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q96NB1}. Cell projection, cilium {ECO:0000269|PubMed:20551181}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:20551181}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q96NB1}. Note=Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP. {ECO:0000250|UniProtKB:Q96NB1}.
Interaction partners:
- Pre-mRNA-splicing factor ISY1 homolog
- Homeobox protein goosecoid
- Centriole and centriolar satellite protein OFD1
- Predicted gene 45140
- Centrosomal protein CCDC61
- Protein moonraker
Sequence:
MATVTELKAVLKDTLEKRGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAESGQPVVPLDRQFLIRELNAFEESKDNSIPLLYGILAHFLRGPPDGAQNVLLTESTLHPATKHLSWKPSRRPDDDHVRKDTGPRTTTEELPAAAQAVSR
Protein: Troponin C, skeletal muscle (P02585)
Organism: Homo sapiens (Human)
Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Interaction partners:
- Troponin I, fast skeletal muscle
- Troponin T, fast skeletal muscle
- Troponin I, cardiac muscle
- Myosin regulatory light chain 11
- Troponin T, slow skeletal muscle
- Troponin T, cardiac muscle
- Actin, alpha skeletal muscle
- Troponin I, slow skeletal muscle
- Myosin light chain 1/3, skeletal muscle isoform
- Tropomyosin alpha-3 chain
Sequence:
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
Protein: Protein mothers against dpp (P42003)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the function of decapentaplegic. May play an important role in mediating Dpp signaling. Involved in the BMP signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17507407}. Nucleus {ECO:0000269|PubMed:17507407}.
Interaction partners:
- Mothers against decapentaplegic homolog
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- E3 ubiquitin-protein ligase Smurf1
- Transcriptional coactivator yorkie
- Mothers against decapentaplegic homolog
- Protein decapentaplegic
- Sno oncogene, isoform B
- Mitogen-activated protein kinase ERK-A
- Schnurri, isoform F
Sequence:
MDTDDVESNTSSAMSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAISSVS
Protein: Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) (P22736)
Organism: Homo sapiens (Human)
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493}. Cytoplasm, cytosol {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340}. Mitochondrion {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18690216}. Note=Nuclear export to the cytosol is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:22427340}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Retinoic acid receptor RXR-alpha
- Histone acetyltransferase p300
- RAC-alpha serine/threonine-protein kinase
- Mitogen-activated protein kinase 3
- Protein c-Fos
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Mitogen-activated protein kinase 7
Sequence:
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
Protein: Protein SEH1 (Q93VR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for proper export of mRNAs from the nucleus to the cytoplasm.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:21189294, ECO:0000269|PubMed:22902705}. Nucleus {ECO:0000269|PubMed:22288649, ECO:0000269|PubMed:22902705}. Cytoplasm {ECO:0000269|PubMed:22288649, ECO:0000269|PubMed:22902705}. Nucleus, nuclear pore complex {ECO:0000305|PubMed:21189294}. Note=Part of the cellular SEH1 pool is not permanently associated with the Nup107-160 complex. {ECO:0000305|PubMed:22902705}.
Interaction partners:
- Nuclear pore complex protein NUP54
- Nuclear pore complex protein NUP107
- Nuclear pore complex protein NUP155
- Nuclear pore complex protein NUP35
- Protein transport protein SEC13 homolog B
- Nuclear pore complex protein NUP96
- Nuclear pore complex protein NUP205
- Nuclear pore complex protein NUP160
- Nuclear pore complex protein NUP88
- Nuclear pore complex protein NUP85
Sequence:
MAKSMATLDSGTTCSSWNQSGDRLAAGSLNGKLSIYESSTSSSSTFSCTSKVRVSESSIVKIVWLPSEYGDAVACVCEDGSLSIWEELSEDAHGLEWKLCKSMKNKSSQVLDVQFGVSRKSLKMVAAYSDGYLRVFELLNPLELKNWQLQAEFQNVIDSLSTLGKPSSLSASVSWNPMKGEEQEPSFVLAFNSDSPHLNSSKIWEFDEAHNRWLAVAELALPEDKGDPVYALSWAPNIGRPYEVVAVATHKGIGIWHVGLAPDLEGRLPVKKVSSLSGHQGEVWQMEWDMSGMTLASTGSDGMVKLWQSNLNGEWHEQATLEPVPS
Protein: Transcriptional protein swt1 (Q9P7J1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in transcription.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nucleoporin nup60
- NTF2-related export protein 1
Sequence:
MDRMEIDDQAGIDFVTESINSERARNRWSTSHIPSLSEINPSSFQSPSPSPFASSTSLASKPARYSKPLGLFVLDTNFLLSHLSLCQNLIEFLTARCPRLVVVLPWTVLQELDGLKSESSSTCGYLARQAHNFLLQCFRSNVSSLRGQKVHEHCSSTEKGDDAILDCCIYYQEEKLIPAVLLSDDKNLSIKAAVHHIQSLSFSKGLEAASIVQTSFPSAFSSNSENLENLSMDIDLTVSQPLATATNHRNQGASTVDIPMDRTHDNSIWASRYAHFPPYDKKKDTTRSAADYIPYTYTALTKEEILHASHPRACKLLDQITKIMVEETAFLLSRHLLKLWGDYDLAMTKLLASPQFPPQNINDVGHELYIHWYTCFDGYLPAQERSNLKSKAELWNEWMLWAERGIGIGPKNQEELQTYVTFWSNIWTLLSRREILGDQASTYIGFREQNIEKWVERSGRERILS
Protein: Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4) (P48035)
Organism: Bos taurus (Bovine)
Function: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P04117}. Nucleus {ECO:0000250|UniProtKB:P04117}. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250|UniProtKB:P04117}.
Interaction partners:
- Adiponectin
- Fatty acid-binding protein 5
- Hormone-sensitive lipase
- Gastrotropin
- Fatty acid-binding protein, liver
- Peroxisome proliferator-activated receptor gamma
- Fatty acid-binding protein, heart
- Fatty acid-binding protein, brain
- Platelet glycoprotein 4
- Perilipin
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPTLIISLNGGVVTIKSESTFKNTEISFKLGQEFDEITPDDRKVKSIVNLDEGALVQVQNWDGKSTTIKRKLMDDKMVLECVMNGVTATRVYERA
Protein: Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Phospholipid hydroperoxide glutathione peroxidase GPX2) (EC 1.11.1.12) (Q9JHC0)
Organism: Mus musculus (Mouse)
Function: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P18283}.
Interaction partners:
- Glutathione reductase, mitochondrial
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Glutathione synthetase
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Polyunsaturated fatty acid 5-lipoxygenase
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Glutathione-specific gamma-glutamylcyclotransferase 1
- Putative glutathione-specific gamma-glutamylcyclotransferase 2
- Thioredoxin
- Hematopoietic prostaglandin D synthase
Sequence:
MAYIAKSFYDLSAIGLDGEKIDFNTFRGRAVLIENVASLUGTTTRDYNQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFSLTQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRSFQTINIEPDIKRLLKVAI
Protein: Putative NADPH dehydrogenase C5H10.10 (EC 1.6.99.1) (Old yellow enzyme homolog 2) (Q09671)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MAVQKLYESQSKLFQPIKVGNMQLQHRMVHAPATRLRCLDNGLVMTDLVKEYYKQRSSIPGTLLITESLFSGAKSGGFSNIPCLYNDEHVEAWKPIVQAIHDNDCFVFIQFWNLPGELKVDYLEDQERLEKVTQGECPMDPTGLPAALGSAYSICGEELYVDKFMTKQDIQEHITTYTEAAKRAVFGCGADGVEVHQVNGFLLDKFVLNGYGDKCDPEYCGSLENRARFCLELLESVVNAIGQERVGYRISPFSDIWKDKDSFEAHVFMIKKIKERFPNLAYLHAIEPRQYWNGHVHITQEKNTLIYKNLWGDPFITAGGHDRDSAIQMAEQENTLVAFGRYFLSNPDLPFRLKYNLPLNKWDRATFYTKMSPKGYIDYPFSKEFLDTKKVE
Protein: Myb-related protein A (A-Myb) (Myb-like protein 1) (P10243)
Organism: Homo sapiens (Human)
Function: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P51960}.
Interaction partners:
- Protein lin-9 homolog
- Protein lin-37 homolog
- Protein lin-54 homolog
- Protein lin-52 homolog
- Histone-binding protein RBBP4
Sequence:
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL
Protein: Orofacial cleft 1 candidate gene 1 protein homolog (Orofacial clefting chromosomal breakpoint region candidate 1 protein homolog) (Q8BGX4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDKEKFQQKAVKQTKQKKSTSAEFLMVKEYTDATEGAGNPGFNMSSPELPAHQTPQEKVVRHDMLDHTLATHQQKSRLPASAGPKGVTSVLIVLTLAALLIRPGCPEREPGIPLKRACTASVEDLFGARVGGDAAEDLCTHWVQVTHSFVGEGYERMNSLFFGRLR
Protein: Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) (Q8VBY2)
Organism: Mus musculus (Mouse)
Function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Calmodulin-1
- Calcium/calmodulin-dependent protein kinase type IV
- Calcium/calmodulin-dependent protein kinase kinase 2
Sequence:
MESGPAVCCQDPRAELVDRVAAINVAHLEEADEGPEPARNGVDPPPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLGAQVGPYSTGPASHISPRSWRRPTIESHRVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGSLLMKEGCGEGCKSPELPGVQEDEAAS
Protein: t-SNARE affecting a late Golgi compartment protein 2 (Syntaxin tlg2) (Q9P6P1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: t-SNARE that functions in transport from the endosome to the late Golgi and on the endocytic pathway.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 45
- t-SNARE affecting a late Golgi compartment protein 1
- Synaptobrevin homolog ykt6
- Vesicle transport v-SNARE protein vti1
- Synaptobrevin homolog 1
- Probable vesicular-fusion protein sec17 homolog
- Protein transport protein gos1
- Syntaxin-like protein fsv1
- Syntaxin-like protein psy1
- Integral membrane protein sed5
Sequence:
MAYRDRTGLYITFRQSYSHHGQRLELSGWDPKEERQSLVHKDNKDNTVIEMDMLAPRWVTVEGEIDSLLLNTRRNINLLDKQYAKHVLPSFSDKTEQENEIQRLTIQITQDFQRCQKLLQVTKAQTNSATGSEALMAKNFLSNLASRIQTESAQFRKKQSTYLKKLRGLNANISPVESKLDETVSDVAISQSTIQQVALMEEQGEDEQAIRHERAVAKIAEGIIELAQMFQDLQVLVIEQGALVDRIDFNIEQTQVHAKSAEKELIKAESHQKNTGRLRFICFLILLIVALIVILAIKLLR
Protein: FI08063p (Q8IQJ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- N-alpha-acetyltransferase 20
- IP11188p
- Uncharacterized protein
Sequence:
MTSFQIRLISDQNLVLVDALHHESEIFVPQIYNNDIVLWNIIRDRRSNPKVEFCEEPVQGQGNGQICQRPQIQPRITTATAGLAPWAASIDGSPFRRVAEEGSRCPLFSLKLISNGSVVLVECNVHESEIFLPQICGQYIAMKRITGHELLLPSKPKISAIQPAKTNCLRIQPTRFFSKTTNLDNQAKKRRKRKSQEQTNHSGAGDQRTLKSVKR
Protein: Proteasome activator 28 (PA28 homolog) (Q967U1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Subunit of the 11S REG (also called PA28) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates preferentially the trypsin-like catalytic subunit of the proteasome. May also be involved in cell cycle regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19411624}.
Interaction partners:
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit beta type-6
Sequence:
MSKNNSTVIKMDEQVLKYKEDLYEKTVHHLKVTIPKKIAEYQELAKSYGQNSENEQDGQTSKKRKLDSEDYVLMPIEDLIKTNRVIMETHQKFKKAYIELIETFSVIRGWISLNIPRIEDGNNFGVDVQEDIITQITKLEEVYTSLLDGSESYFASRASLVKKILKHKDIEAYRYSLAQVDEKEFTRFSFSYFDLANNYATTYSLIVKNFAKLETPRPTNASNIY
Protein: Pentatricopeptide repeat-containing protein At3g49240, mitochondrial (Protein EMBRYO DEFECTIVE 1796) (Q9M3A8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in embryogenesis.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Interaction partners:
- DEAD-box ATP-dependent RNA helicase 3, chloroplastic
Sequence:
MSISKAAFLNHLQTLSRSYRHRVLPQPFLAVRYMSFATQEEAAAERRRRKRRLRMEPPVNSFNRSQQQQSQIPRPIQNPNIPKLPESVSALVGKRLDLHNHILKLIRENDLEEAALYTRHSVYSNCRPTIFTVNTVLAAQLRQAKYGALLQLHGFINQAGIAPNIITYNLIFQAYLDVRKPEIALEHYKLFIDNAPLNPSIATFRILVKGLVSNDNLEKAMEIKEDMAVKGFVVDPVVYSYLMMGCVKNSDADGVLKLYQELKEKLGGFVDDGVVYGQLMKGYFMKEMEKEAMECYEEAVGENSKVRMSAMAYNYVLEALSENGKFDEALKLFDAVKKEHNPPRHLAVNLGTFNVMVNGYCAGGKFEEAMEVFRQMGDFKCSPDTLSFNNLMNQLCDNELLAEAEKLYGEMEEKNVKPDEYTYGLLMDTCFKEGKIDEGAAYYKTMVESNLRPNLAVYNRLQDQLIKAGKLDDAKSFFDMMVSKLKMDDEAYKFIMRALSEAGRLDEMLKIVDEMLDDDTVRVSEELQEFVKEELRKGGREGDLEKLMEEKERLKAEAKAKELADAEEKKKAQSINIAALIPPKAVEEKKETAKLLWENEAGGVEEADVVEMAKGVEAGGSNGQDPPSC
Protein: Zinc finger CCCH domain-containing protein 14 (Suppressor of tau pathology protein 2) (Q95XU6)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000269|PubMed:19273536}. Cytoplasm {ECO:0000269|PubMed:19273536}. Note=Mainly nuclear. Small amounts are found in the cytoplasm. {ECO:0000269|PubMed:19273536}.
Interaction partners:
- RNA-binding protein Musashi homolog 1
- Nuclear cap-binding protein subunit 2
- Importin N-terminal domain-containing protein
- RRM domain-containing protein
- Spliceosome RNA helicase DDX39B homolog
Sequence:
MNTQTGTGTSEVSKKLKAAIRAKLEELGVYVDDELPDYIMVMIANKKEKVQMKDDLNLFIGKSTAKFVDWLFDLFDRLQNASNKQGETSKKEEDKRKELEATAAAKEHEEKRRKEKEEHEKELQKEKEREKERQRERDREKRAEEEKRREEKRKEIQRSKRRRTRSRSNTYSDEEEHVRARGEKHDRHHHKDHRRGRSHERKIITSTIVRQASASPDKKLHSTVTVKRNIRPTGDQNIKGRGTMFLRAMNEASVSAGYGSSSKRSETHHEDDMSDVEALPSKPASTKSPKKSIRDRMSRISKTSEPPIEEDDAVVLEDFAQTGGGPQMILKLSGGREAIKKTRIQDRIVVDDGLRRGLLKRKIETASGASAGAATSEEPKSKHDRIIFDITPSRDSTPTDDSPTMQKWNGQIEIGDDSEESEDDEEAEIDAFVAEARGIARRESFRDEEDELPPTHQLSGGPYAYHHSTAAPTYIPTPLSVLSEQQNQMGGGAAKEDHHVKERCIFWPKCTKGDTCAFMHPTTNCKNFPNCTFGIRCLFIHPPCRFDRFCTKKHCPFTHHGTGGQQPGGAQLTSEFKNPLTSSRMLTVPSPFIAATAAAVEELPKPAARGALGSLAEKLAASIKKKPAPGAESEKKEEKSDENESKAEEPKAEVAPVQPKPLPDIAPLHSMVLCRYAGACRNPICHFKHPKECRFGANCRNPSCYFYHKPAGAAPTPVAAPIAAESAGAAKYKWTSATAN
Protein: FAD-dependent monooxygenase paxM (EC 1.-.-.-) (Paxilline synthesis protein M) (Q9C447)
Organism: Penicillium paxilli
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEKAEFQVIIVGGSIGGLTLAHCLHRAGIKHVVLEKASDPAPQIGASIGILPNGARVLDQLQLYDQVEEHIEPLSKATIGLPDGFNFSSSYPKIIDQRFGFPIAFLDRQKMLEILYKGYPDPSKIRLGQRVTSIESLDDGVLITTTTGHVYRGDLLVGADGVHSIVRREIWKARGIARRVSKIKQDSSKLTVEFRCIFGISSAMPGLKLGEQVNALFDGLTIVTIHGKDGRIYWFVIQKLGKKYVYPDSPRYTSHETSIAAEEIRDVKFYENITFGELWDKRETSSMTALEENTFKVWHHGRCVLLGDSVHKMTPNVGQGANMAIEDAAALANLLRKMRISSGPYFPTSSQMEFLLQKYRDLRYERVNTIYQSSRFLVRFQVRDGIIYSLLSRYWAPYAGDLPADMASKTIADGTMCDFLPTPKRSGGGWEKYSKQGRSWSYLTQLMIYLFGLTIVYTSLTMMFDLEGALKFYFLQV
Protein: GntR family transcriptional regulator (Transcriptional regulator of bph operon BphS) (E7FJA6)
Organism: Acidovorax sp. KKS102
Interaction partners:
Sequence:
MTKQDQAVLPRLIESARLPEGALAEFNVGPKEKKAVTAIESTYATLRDAILRGSYPQSSRLHLETLKSSLGVSGSTLREALTRLIGDRLVVAEGQKGFRVAPMSLCDLDDLTSARIMLESAALVESINLGGDGWEDQLVTSFRRLTRAQERVEANPAEAFDAWEARNLEFHNALMAASPSKWLANFREILLRNSERYRRLSGTQGPLPAEVHEEHKTIFDAAMARDVDRAVSALSQHIRRSANVIRANGLLRKV
Protein: Protein phosphatase 2C 7 (AtPP2C07) (EC 3.1.3.16) (Protein HYPERSENSITIVE TO ABA 2) (Protein phosphatase 2C HAB2) (PP2C HAB2) (Q9LNP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.
Interaction partners:
- Abscisic acid receptor PYR1
- Abscisic acid receptor PYL8
- Abscisic acid receptor PYL9
- Serine/threonine-protein kinase SRK2I
- Serine/threonine-protein kinase SRK2D
- Abscisic acid receptor PYL5
- Serine/threonine-protein kinase SRK2E
- Serine/threonine-protein kinase SRK2G
- Serine/threonine-protein kinase SRK2J
- Serine/threonine-protein kinase SRK2B
Sequence:
MEEISPAVALTLGLANTMCDSGISSTFDISELENVTDAADMLCNQKRQRYSNGVVDCIMGSVSEEKTLSEVRSLSSDFSVTVQESEEDEPLVSDATIISEGLIVVDARSEISLPDTVETDNGRVLATAIILNETTIEQVPTAEVLIASLNHDVNMEVATSEVVIRLPEENPNVARGSRSVYELECIPLWGTISICGGRSEMEDAVRALPHFLKIPIKMLMGDHEGMSPSLPYLTSHFFGVYDGHGGAQVADYCHDRIHSALAEEIERIKEELCRRNTGEGRQVQWEKVFVDCYLKVDDEVKGKINRPVVGSSDRMVLEAVSPETVGSTAVVALVCSSHIIVSNCGDSRAVLLRGKDSMPLSVDHKPDREDEYARIEKAGGKVIQWQGARVSGVLAMSRSIGDQYLEPFVIPDPEVTFMPRAREDECLILASDGLWDVMSNQEACDFARRRILAWHKKNGALPLAERGVGEDQACQAAAEYLSKLAIQMGSKDNISIIVIDLKAQRKFKTRS