wanglab/gogpt-training-data huggingface dataset:
Protein: Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (D3ZEY4)
Organism: Rattus norvegicus (Rat)
Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P52824}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P5E8}. Cell membrane {ECO:0000250|UniProtKB:P52824}. Synapse {ECO:0000250|UniProtKB:Q6P5E8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P52824}. Nucleus {ECO:0000269|PubMed:15337525}. Nucleus speckle {ECO:0000269|PubMed:15337525}. Nucleus matrix {ECO:0000269|PubMed:15337525}. Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. Translocates to the nucleus in response to thrombin stimulation (By similarity). Association with the nuclear matrix is regulated by nerve growth factor (PubMed:15337525). {ECO:0000250|UniProtKB:P52824, ECO:0000269|PubMed:15337525}.
Interaction partners:
- Lipoprotein lipase
- Dihydroxyacetone phosphate acyltransferase
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Cyclin-G-associated kinase
- Endosomal/lysosomal proton channel TMEM175
- Phospholipase D2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- 1-acylglycerol-3-phosphate O-acyltransferase 3
Sequence:
MATAAESGARTWPGSGSPRLGSPAGSPVLGISGRARPGSGPERTGRAIGSVAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPVAHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQHDYDTYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALTPECTFGRLRSMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGLDGSAAVGTGREVSAATESTKQTLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYINEDPKDFQLQALPLTLLSGNAQALGKAGTTEEETSKDSGPGDSVPEAWVIRSLPRTQEILKIYPDWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGRQVEDQERFQLIEVLMSSRQVQRTVLVDEEPLLDRLRDIRQTSVRQASQTRFYVAEARAVTPHVSLFVGGLPPGLSPQDYSNLLHEAMATKAAVVSVSHVYSLQGAVVLDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPCFRVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWTILLDAHEIDSTENNVVETEPPKIVQMNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQKISHSRSLHKEIRLQVEQQEVELPSIEGLIFINIPSWGSGADLWGSDSDSRFEKPRIDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWIQAPGHMIISATAPKVHMLRKAKQKPRKAGAIRDTRVDTLPAPEGNPL
Protein: Crossveinless d (GH05619p) (Q9VF24)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Microsomal triacylglycerol transfer protein
- RE18169p
Sequence:
MRLLKCSVFVYLFLIFDAGHAFSIIGLNKQMLYEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNNSGEKFLQNKEMYPPYKPFKIALTKDGAISHVVFKEGDPIWSMNFKRAIASVLQFQMKSSGAFVVDELGIHGTCRTEYFVSNRTNYISIRKTPEVKTCKPYSEAVHTTRSNVPPNTCEFDHQKSVIIGNEAIYGMSPHNETGYYLSMAHAKGTTLIHTFESTGEAQFINSELLLNFLNETPIDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQETLIAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQETIRNIFHEIIPRIGTKASVFLTHHLVLNKLTKPQIAVQLLIPMPFHIFELSAELVQKCEDFLNIGPDRPDVRQAAILSFATLIHNVYVAKGIDKEKFEEYVQKYFNAYLSDRDFDQKMLYLQGLNNLQLGNVANYLEPIVQDPNEHEDLKFQAAWTTLALADRRAERIYEVYWPIFESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETTYPCYQHLRRLLSYMHRHLPQKPESRYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMPVVAFFKFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFTFKSIKALLAMLQAPIINSKDLHLEFILQMEGKTVLSYYLNQRMFRQLTYDNILERMQQIIRTDSHINMQTVRWPFMNRYTVPTVLGTSSDVLLQTTVLTSLRGNITEQRNSPITKHTLEIDARYSSYASVRSRSYNPFLNLDHEINREQGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTSGLSFKSRAVTKTRGLITKTAAAPFEEIMVPEGRNDVVQLFSYPMTDLGVRLSMTTNLNELIKYRGMLLKSEFTENGFSGNMVVNALMYIFGFTQLSSIHLGHDRNFTMLMYNEKNTRIEGNFCAEDVLKTSDMKGKQIGLTLEHTDHMNENHAADALHRWNITLDVLASTKSNWFKLTGQVQRNSKDDEDDWKACTKLTYEPLVFTKRPHTLNGDVVFGLATEESECPEKGSTVQFAARAGPSEHARAFLRSDKISLTDTDFCPKEVLKFSPIPTSRYCKRSNFENFTSITQYDMDLKFDNMPAWFELWSNRLDHLVSALSADKVDSLHMSQEINISMQTPQDQFRLAVEVNGVKWRFHQIPFFYKLDSKFDASHELTFDSGLKRSCSVINGIVNTFDDYLINLREIAVRPDCLTLLVADCSPLPQIAVFVTPSPVQGLSTNYGLRVHIGQNYFNFRARTDNSSLPTDEPVLIYLNQDQTPHNVRKKPYQWPIETSDYDFRVELNEQNILIVECTQLSSTIQFDLYNILNFEIYGVYKHQMCGLCSKPLNRMQNYTICELEANTPTPVPLQNSSDVVVVA
Protein: Myb-related protein 1 (Myb family transcription factor PHL10) (Protein PHR1-LIKE 10) (Q9FK47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that may act on the GAL1 promoter. Acts redundantly with MYR2 as a repressor of flowering and organ elongation under decreased light intensity. Represses gibberellic acid (GA)-dependent responses and affects levels of bioactive GA.
Subcellular location: Nucleus {ECO:0000269|PubMed:21255164}.
Interaction partners:
- Pectate lyase
- Protein GLUTAMINE DUMPER 3
- Myrosinase 1
Sequence:
MYYHNQHQGKSILSSSRMPISSERHPFLRGNGTGDSGLILSTDAKPRLKWTPDLHERFVEAVNQLGGGDKATPKTIMKVMGIPGLTLYHLKSHLQKYRLSKNLNGQANSSLNKTSVMTMVEENPPEVDESHSESLSIGPQPSMNLPISDALQMQIEVQRRLHEQLEVQRHLQLRIEAQGKYLQSILEKAQETLGRQNLGAAGIEATKAQLSELVSKVSADYPDSSFLEPKELQNLHHQQMQKTYPPNSSLDSCLTSSEGTQKAPKMLDNRLGLRTYIGDSTSEQKEIMEEPFFHRMELTWAEEESLRENHNRPYLSTMVNNAEPRISSSRRSPGRLSIGVGLHEHRGRSSNNSEYTEERFNENNEDCKLETHTRTALDLNTHDENYGTTRPKQFDLNGFSWN
Protein: tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16) (Splicing endonuclease of 34 kDa) (tRNA-intron endonuclease SEN34) (P39707)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.
Subcellular location: Nucleus {ECO:0000269|PubMed:12925762}. Endomembrane system {ECO:0000269|PubMed:12925762}; Peripheral membrane protein {ECO:0000269|PubMed:12925762}. Mitochondrion outer membrane {ECO:0000269|PubMed:12925762, ECO:0000269|PubMed:16823961}; Peripheral membrane protein {ECO:0000269|PubMed:12925762, ECO:0000269|PubMed:16823961}; Cytoplasmic side {ECO:0000269|PubMed:12925762, ECO:0000269|PubMed:16823961}. Note=The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria, suggesting that tRNA splicing mainly takes place on the mitochondrial surface.
Interaction partners:
- tRNA-splicing endonuclease subunit SEN15
- tRNA-splicing endonuclease subunit SEN2
- tRNA-splicing endonuclease subunit SEN54
- tRNA ligase
- tRNA 2'-phosphotransferase
- RNases MRP/P 32.9 kDa subunit
- Ribonucleases P/MRP protein subunit POP1
- Ribonucleases P/MRP protein subunit POP3
- Ribonuclease P/MRP protein subunit RPP1
- Ribonuclease P/MRP protein subunit POP5
Sequence:
MPPLVFDIDHIKLLRKWGICGVLSGTLPTAAQQNVFLSVPLRLMLEDVLWLHLNNLADVKLIRQEGDEIMEGITLERGAKLSKIVNDRLNKSFEYQRKFKKDEHIAKLKKIGRINDKTTAEELQRLDKSSNNDQLIESSLFIDIANTSMILRDIRSDSDSLSRDDISDLLFKQYRQAGKMQTYFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQDAIDYHNEPIDLISMISGARLGTTVKKLWVIGGVAEETKETHFFSIEWAGFG
Protein: GH19777p (Q86NW3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
SRSNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYDDDMKTGPVGGSMGGGGPALGLGADGAGLGIPTMPRRKSAYDVFAPGLTQGGATPATQLQRSPGEGGIMPPIQLPGSRRPSFRVPHPSEDIQNDDSPGSPDKGSPVLTVDDDRRMRRRGSQLPDIAMLQNRGALPAVPPSSIPPPMASFTGPNLEDLEAPRRQTSMDGEAIRIVIHDVDSGPICASKRRIILRRDPTDKAHRTRGFGMRVVGGKTGADGRLFAYIVWTVPGGAAEKNGLQQGDKILEWNGMSLIDRSFEEVCSIMDRTGDVVELLVEHATDFRMCDLFDENLPPGNAGGQSGPRRSGDGPVGLGLIAEPETTTDKSPASPTRRKLPKTPV
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (Q7KPK6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAERPKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMIFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADILESMEKDGITQFTANQQAES
Protein: Probable two-component response regulator (Q9HZD1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable two-component sensor
- histidine kinase
- histidine kinase
- histidine kinase
- Sensor protein
- Sensor protein kinase PmrB
- Sensor protein
- Sensor protein
- Sensor protein
- histidine kinase
Sequence:
MHIHVLVVEDNFDLAGTVIDYLEAAGVVCDHARDGQAGLNLARANRYDVILLDIMLPRINGRQVCRQLREAGLQTPVLMLTALDTLQDKLDGFDAGADDYLLKPFELPELLVRLQALSRRRSGQAQRLQVDDLVMDLDSRQASRGGTPLALSPTAWKILECLMRASPALVTREQLGRSVWGDEPPESNTLNVHMHHLRSTVDKGFATPLIHTLHSVGFQLERK
Protein: Cardiac-enriched FHL2-interacting protein (Q711Q0)
Organism: Homo sapiens (Human)
Function: Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:M0RD54}.
Interaction partners:
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Sequence:
MMQGNKKCTDAFSDSSSIGSVLDDADREVSSLTDRAFRSLCISEDTSFHDSYLAVSPDITRQVFGTFHQRTVGHTQRKSGIWSQLPSQGTEHSGWAATFQQLPKYVQGEEKYPKTSPPPTPVQRRLEVPVSGLRSSNKPVSKVSTLIKSFDRTESQRCESRPTASKPPALKNPPKFAPLPENSVNFCFDSAFLTVRRVPAEVSNTHQNSYQPGRKHGEQESSKNPEMACHGSSSFLPAANDTATLCESKFPSPHHKPVTGEPGRGKGTFLHSENSAFESWNAHQPKLLERKDTAGTVPESKAPKHYGDTTLLREPCPPERTVSPCQVQASCSQEENRLAAGALSTSIPWGCRDPGAQVFAVEGKAPSSQPDSQEKPAQPPWRKPKTGKKGKESLQDTLEEKTQTNQRGPPLYTKHNPQEQFSENNALDLPVEPNEHYDPPFNISKLLTPIIPSKHALDSADSQPAERTPSPPGQLNGYQEKEPSECQSRDSYKSKAPSLLFNLKDVRKRVKSTYSSSPLLKVLDEKTRGKVDGKQEPVSNGVILPNGLEESPPNELSKERPADDPTASHINPQKDPTADPSEPSADSYLTLSTAPTIAKAPFYVNGEAAERSSYENKEVEGELEMGPAGSSWCPDSREHRPRKHLSLRLCNRDPEPGGATEKMKTHQLENGLSRSVSQETEPEREAGLQNTHLNQKFFPGPLSPEEEDVFYSDSQSDFMPSLKGKAKFSTSSSDQSFASFDDQQKMWFTENQREDRRKDVSAGDSQKDEKENVMRKDELQYCALSNGHACLENRSQGEALQRERESVSGGRTRKASAEEANFRGSWIGENKGTTFSQAKDLTPSPSSASNRHMLFTIKDNTLRATPVIKPIMLPLLRTMSLEDSLSSGHKEEELPRPEWGEDPGFCAPENQDILGTSTPTNTRGTRVKCMANEVMEDPGQGSSMARMEASQPAPKGNFPSMPLVGEGDRVKAPPDAAPGLVASNCKSGSADSGKLAAPWHIPTIALPEGDIEDQPPPWQPENCWEEQTPGFKSHFLSTPRAGPPGRRLVPSERANSPNPGSPGESSACSPAASNIWEESSQAPGGPELLPEEPNQASPWASSSPARVTRREDLTHALVWEGGSDPLLELSAEDLRTLSPRGSLLDVATSPAGTSGRLELPAQLERTASKPPAVPPKTEKALRRAKKLASKRRKTDQAQEKHGESQEGKPCPEDLEQTQQRPLCPRERPRHNFPVVRSLPPPVHRHSVSGFSEPVGRRPGGPQSLTPLPAYPATQKVLQDPQSGEYFVFDLPLQVKIKTFYDPETGKYVKVSIPSSEGASPEPPPPDALAAPYVLYPGFQPVPVTALMPLRCSSQLSAPTFLRQGPRASAARARTQSVHESGLQLDPGPHGDCTPHSAGQRPHGPPQSPGEEGVEAPGLGIISTDDLEDFATEGIS
Protein: Thrombospondin-related apical membrane protein (Q8I5M8)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MIDVLLNKTNYLYFTFLLFLYISSNDLCSCNLKVRNNWEHFLQVYQNNGNFKMEILEPECTIQKNLPSEEEKEEFIDFDRKELLLHDFVVIKNSQFTDEKTLELYLSKEENNKSYLMLTFYLGDLKLMIGHNSPYEISLILNVATVNKNMSNCKNNSYNIVLLKTTDVFNTSDLEILEGPIQFSLGKSSGAFRINVTNFFLNNTWKAFTKDKISFLIKPEENCYTILENKINKPQLLIEKKTTFYSEWGEWSNCSMDCDHPDNVQIRERECIHPSGDCFKGDLKESRPCIIPLPPCNELFSHKDNSTFKILMIILPIVLVISIITILYHIFYKRKGAEKELYENVAGRYMYD
Protein: Potassium/proton antiporter CemA (Chloroplast envelope membrane protein A) (CemA) (P0C302)
Organism: Oryza sativa (Rice)
Function: May be involved in proton extrusion. Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000255|HAMAP-Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01308}.
Interaction partners:
Sequence:
MKKKKALPSFLYLVFIVLLPWGVSFSFNKCLELWIKNWWNTRQSQTLLTAIQEKRVLERFMELEDLFILDEMIKEKPNTHVQNPPIGIRKEIIQLAKIDNEGHLHIILHFSTNIICLAILSGSFFLGKEELVILNSWVQEFFYNLNDSVKAFFILLVTDFFVGFHSTRGWELLIRWVYNDLGWVPNELIFTIFVCSFPVILDTCLKFWVFFCLNRLSPSLVVIYHSISEA
Protein: Probable quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (P38230)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MKCTIPEQQKVILIDEIGGYDVIKYEDYPVPSISEEELLIKNKYTGVNYIESYFRKGIYPCEKPYVLGREASGTVVAKGKGVTNFEVGDQVAYISNSTFAQYSKISSQGPVMKLPKGTSDEELKLYAAGLLQVLTALSFTNEAYHVKKGDYVLLFAAAGGVGLILNQLLKMKGAHTIAVASTDEKLKIAKEYGAEYLINASKEDILRQVLKFTNGKGVDASFDSVGKDTFEISLAALKRKGVFVSFGNASGLIPPFSITRLSPKNITLVRPQLYGYIADPEEWKYYSDEFFGLVNSKKLNIKIYKTYPLRDYRTAAADIESRKTVGKLVLEIPQ
Protein: Chaperone protein dnaJ 50 (AtDjC50) (AtJ50) (Q8GUN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in protein folding in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:18718935}; Multi-pass membrane protein {ECO:0000305|PubMed:18718935}.
Interaction partners:
- Chaperone protein dnaJ 20, chloroplastic
- Large ribosomal subunit protein uL4z
- Large ribosomal subunit protein uL4y
Sequence:
MAPPVTERWCLALILLFLSLFVQSSTAIYCGAEDCYALLGVAQDANASDIKRSYYKLSLQHHPDKNPDPESRKLFVKIATAYEILKDNTTRAQYDYAIEHPEEVFYNTAQYYRAKYGHKSDPRAVLVGLLVVLSAFQYLNNVARYNEAIATVKRTPAYKNKLKALELERTGGVSNKKKGSKQIDQKLQEELSNELDLQIKGAEKPSVWELLGVRFILLPYTIIKLLVWYSSWVWRYKVKKAPYSWEDASYLTRRSLSVPADAWANLDEYRKEDLVQKRLWEKQNLENYFAEMRKESKRRR
Protein: Transcription regulator NOT2/NOT3/NOT5 family protein (F4JWJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGASRKLQGEIDRVLKKVQEGVDVFDSIWNKWNVYDTDNVNQKEKFEADLKKEIKKLQRYRDQIKTWIQSSEIKDKKVSASYEQSLVDARKLIEKEMERFKICEKETKTKAFSKEGLGQQPKTDPKEKAKSETRDWLNNVVSELESQIDSFEAELEGLSVKKGKTRPPRLTHLETSITRHKDHIIKLELILRLLDNDELSPEQVNDVKDFLDDYVERNQDDFDEFSDVDELYSTLPLDEVEGLEDLVTAGPLVKGTPLSMKSSLAASASQVRSISLPTHHQEKTEDTSLPDSSAEMVPKTPPPKNGAGLHSAPSTPAGGRPSLNVPAGNVSNTSVTLSTSIPTQTSIESMGSLSPVAAKEEDATTLPSRKPPSSVADTPLRGIGRVGIPNQPQPSQPPSPIPANGSRISATSAAEVAKRNIMGVESNVQPLTSPLSKMVLPPTAKGNDGTASDSNPGDVAASIGRAFSPSIVSGSQWRPGSPFQSQNETVRGRTEIAPDQREKFLQRLQQVQQGHGNLLGIPSLSGGNEKQFSSQQQNPLLQQSSSISPHGSLGIGVQAPGFNVMSSASLQQQSNAMSQQLGQQPSVADVDHVRNDDQSQQNLPDDSASIAASKAIQSEDDSKVLFDTPSGMPSYMLDPVQVSSGPDFSPGQPIQPGQSSSSLGVIGRRSNSELGAIGDPSAVGPMHDQMHNLQMLEAAFYKRPQPSDSERPRPYSPRNPAITPQTFPQTQAPIINNPLLWERLGSDAYGTDTLFFAFYYQQNSYQQYLAAKELKKQSWRYHRKFNTWFQRHKEPKIATDEYEQGAYVYFDFQTPKDENQEGGWCQRIKNEFTFEYSYLEDELVV
Protein: Uncharacterized protein (Q38C47)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSNGYKRERWDEESGDHYHQHAVRYSDLPPNVKLQRRRQERQEKKEKERTLAYFTSVHRALEEQSAETLVAFVDGFFVELIKLLRADTSLHLLRNGTVCRTIEAALASSQLLHCKSLLYILLGHVYDLAASPTASRTLEAIIASIVRGVSVFRRTDSSAFSAEMEEGGASSNGVPSASTLITCVVEELAERAGEVLLHDAAARAVRSIILFLGGFWNSTGTASSLPHGVKFYAQLDTLGTALMCVVEPTFGVSCGDGVANIWLQVAKTPTASFVVQSLLRVCERETKLDASVRQRLEVIHNDGSQLLRQLLMDPLGCHLFQAYLRVPVPASVLKDYDSFSSYQCSGTAPTSSGSGKRFIKMLRDVAAEEPPNPDELAHEKTCWDKALAIVVEALDDLLDPAGSSVGHAVFALQDLVLFAPTAVHLERVWEQLLERIGLRTLLASPKLVQVLIVFTRKCAFSNPLPTVVESEDRSAEAAPLEGGFVGDMVPKDVEQSIYNDLSQGVRYFPTSTEFQKKVLTALLRVARELCPKGAAQFLLVDGGLQDKGFELARYIMHFVPAASAVFLHAIERLRRSDVETLLYHPKGSLVFQQFLRAGAAHHPQGKKGGEQQQEQQRVETMIPLSFMRRISPLLPRLVVNTYAAYVIEVLYDVGSFEVKEELVKALLPIYNEMKRSHEEKQREVREAASRNDPSANPNNFHMSEFITRKVMTKCLVEMYSHRPDDWAKLARRQCQVQRLLQRMSSVAF
Protein: Cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (cAMP-dependent chloride channel) (Q8QFL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
MEPIKKDAKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYWDQEKEKAAKELKTPKLTKAIIRCYWKSYAVLGVFTLIEESIKVIQPVFLGKLIKYFENYRHDDMAALSEAYGYATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQIVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMFGKLFSKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYLRGLNMASFFTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISIRRIKKFLLLDELVKNHLPLSQEEKKEPSVEMQDLICYWDKTLDAPTLQNVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPGTIRSNILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSYSELQQSGLDFTSLLKKDEEEESGSEKGEAPRSPRSRTVSQNSVRSHSSSVLSVKDDSDQLPAEPVHTMAEESRSEGNIGIRMYWKYFRAGANVVMLVLLVLLNLLAQTFYILQDWWLSYWATEQEKLDHNTNNTNTNNTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVSSAETLHNRMFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWILIPVLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAHQDLHSEAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALSYAVTLMGMFQWGVRQSAEVENMMTSVERVVEYTELESEAPWETQKRPSPDWPNRGLITFDRVNFSYSSDGPVVLKNISAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGLHDLRQKMSIIPQDPVLFTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVCLARAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGRIHEYDAPHVLLQNQSGIFYKMVQQTGKAEATSLLQTAKQAYTNRSPAHQLNGFATTGDGSLIIFETAL
Protein: Ly6/PLAUR domain-containing protein 8 (Q9D7S0)
Organism: Mus musculus (Mouse)
Function: Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:27027293}. Secreted {ECO:0000269|PubMed:27027293}. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor. {ECO:0000269|PubMed:27027293}.
Interaction partners:
Sequence:
MRGVFIAGVIAAFAITVVDSLNCTQCYTYNSTCDGQATECNEQSFSCVESSINSTLGGFLHVYQNKFCSASNCTENSTEVAFTVHLFDDQRYHFASQCCQGESCNATHSESGTQNVTDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVELKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQPTEYTNSTTTIPPITNTSLTSVTRPGIKTSPASVTPQASMGTKASFTSSIFGSLLLLKLLF
Protein: Testis-specific RNP-type RNA binding protein (O18409)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLSSLDALAGKIATATPGTGAVTADSKNTQSLHHHHRLDYDYSAVEIEPPAEQLANSPRSERERLQQAQQAYEQQAQAELEFGLAEVDAKLTQLKSSHSLQHHHSHHHQLQRHTALHQQQQQLHHHQPHHNHHHHHPYQRPRPTSPPQQQTSTYQQQLSQLAALQDHHDLLQTQQELFHKQLATMQEYQRERERERERERERERERERDRSSFIDNSDYDSQTEFKICLRDSAFGMSDKSSSATNSLPNSPIHSNNNNPSLLNNNNNNSNGTSSNNSLNVGNNSSNPSLGGTNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDACFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRRAALKAQDALHNVKTLNGMYHPIQMKPADSENRNERKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPAQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQPSLSNAAAAAARATSPGSAQLTNTAALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAAAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKDSKPY
Protein: Keratin-associated protein 10-3 (High sulfur keratin-associated protein 10.3) (Keratin-associated protein 10.3) (Keratin-associated protein 18-3) (Keratin-associated protein 18.3) (P60369)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 10-1
- Keratin-associated protein 10-9
- Keratin-associated protein 10-10
- Keratin-associated protein 10-5
Sequence:
MATSTMSVCSSAYSDSWQVDACPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSPCCQAACEPSPCQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVCSGASSSCCQQSSRQPACCTTSCCRPSSSVSLLCRPVCRSTCCVPIPSCCAPASTCQPSCCRPASCVSLLCRPTCSRLSSACCGLSSGQKSSC
Protein: Sorcin (M0RAF3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MSYPGHPGAGGGYYPGGCGGAPGGPVFPGHTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFSEFRELWTVLSGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTGLSLNPFSITRS
Protein: Aralin A chain (EC 3.2.2.22) (rRNA N-glycosidase) (P83572)
Organism: Aralia elata (Japanese angelica tree)
Function: Toxic type II ribosome-inactivating protein (RIP). Induces apoptosis. Has cytotoxic activity against several human cancer cell lines. Is less cytotoxic to normal human cells.
Interaction partners:
Sequence:
ANFPTVSLNTVGITRQIPQDFMNAV
Protein: IP18018p (Zinc/iron regulated transporter-related protein 71B, isoform B) (Zinc/iron regulated transporter-related protein 71B, isoform C) (A4IJ72)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- LD23375p
- Zinc transporter 63C, isoform F
- Zinc/iron regulated transporter-related protein 42C.2
- RE54080p
- RE15841p
- LD05335p
- FI18611p1
- FI24038p1
- FI20862p1
- Zinc transporter ZIP11
Sequence:
MAQKQVLVLNLFCLGSLFFKTVPASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSHTIDQHRPQGYSNEMPHATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDPKHRHPRESSEPVAACLSPKSLLSLIVNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNEFINSVRITPRAFMKLCPALLAQIDNGVCKQPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVPLMKSAAYQEILKFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPLESDHKHSNEAALLCGCTFLAALFMYMLENLIPLLKGGKPGHGHSHGHGHSHGRSHGHMEKPAAKDAIDLPPPRELNVMLQEAKLDEKTPDRPLTPVAFMVIIGDGLHNLTDGLAIGAAFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGIGDGMTQWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKGIIIQIFGILLGGLIMLAIALNEHDLEGLFKSF