wanglab/gogpt-training-data huggingface dataset:
Protein: Putative NADP-dependent oxidoreductase (Zinc-binding dehydrogenase family protein) (Q9M9M7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glycosyl hydrolase family 10 protein
- At4g33840/F17I5_30
- Glycosyl hydrolase family 10 protein
- Glycosyl hydrolase family 10 protein
- At4g38650
Sequence:
MATSGNATVANKQVILRDYVTGFPKESDLIFTDSTIDLKIPEGSKTVLVKNLYLSCDPYMRIRMGKPDPGTAALAPHYIPGEPIYGFSVSKVIDSGHPDYKKGDLLWGLVGWGEYSLITPDFSHYKIQHTDVPLSYYTGLLGMPGMTAYAGFYEICSPKKGETVFVSAASGAVGQLVGQFAKIMGCYVVGSAGSNEKVDLLKNKFGFDDAFNYKAEPDLNAALKRCFPEGIDIYFENVGGKMLDAVLLNMKLHGRIAVCGMISQYNLEDQEGVHNLANVIYKRIRIKGFVVSDYFDKHLKFLDFVLPYIREGKITYVEDVVEGLENGPSALLGLFHGKNVGKQLIAVARE
Protein: Activating transcription factor 7 interacting protein (F5H2H9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSD
Protein: Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2) (Q96A58)
Organism: Homo sapiens (Human)
Function: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11533059}.
Interaction partners:
Sequence:
MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS
Protein: DNA-dependent metalloprotease WSS1 homolog (EC 3.4.24.-) (DNA damage response protein WSS1 homolog) (Q9P7B5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (top1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped top1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA-dependent metalloprotease WSS1 homolog 2
- Uncharacterized peptidase C18A7.01
- Ubiquitin-like protein pmt3/smt3
- DNA topoisomerase 1
- SUMO-conjugating enzyme ubc9
- Large ribosomal subunit protein uL2m
- Inactive metallocarboxypeptidase ecm14
- Probable tyrosyl-DNA phosphodiesterase
- ATP-dependent RNA helicase has1
Sequence:
MLRINDDDHPNEKIGFISAIKGDFHDLSSDYLKRIAAMAFPIMKEHGFGVTSLDEVAYNAKFWGRNWNKGECIELVLRDASNRWLPFEFVMDVFLHELCHIWQGPHDRRFFSHLSTLRAALIALYAKGYKGPGKYMTWDSFVLANVVGNYNTVVFNGITLERSTMHGVETCGGSLQRKKKIRRKPTPSSTKKRKLTRTGQKLGTDMNIRLELLKSPAKPQAQSMRGREARIAAALLRVDNSNEYKPKDHNSSTTLENYFVVE
Protein: Tautomerase PptA (EC 5.3.2.-) (P31992)
Organism: Escherichia coli (strain K12)
Function: Can use enol isomers of phenylpyruvate, 2-hydroxy-2,4-pentadienoate and (p-hydroxyphenyl)pyruvate as substrates.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Xylose transport system permease protein XylH
Sequence:
MPHIDIKCFPRELDEQQKAALAADITDVIIRHLNSKDSSISIALQQIQPESWQAIWDAEIAPQMEALIKKPGYSMNA
Protein: Histone-lysine N-methyltransferase PRDM7 (EC 2.1.1.-) (PR domain zinc finger protein 7) (PR domain-containing protein 7) ([histone H3]-lysine4 N-methyltransferase PRDM7) (Q9NQW5)
Organism: Homo sapiens (Human)
Function: Histone methyltransferase that selectively methylates 'Lys-4' of dimethylated histone H3 (H3K4me2) to produce trimethylated 'Lys-4' histone H3 (H3K4me3). May play a role in epigenetic regulation of gene expression by defining an active chromatin state.
Subcellular location: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Interaction partners:
Sequence:
MSPERSQEESPEGDTERTERKPMVKDAFKDISIYFTKEEWAEMGDWEKTRYRNVKMNYNALITVGLRATRPAFMCHRRQAIKLQVDDTEDSDEEWTPRQQVKPPWMAFRGEQSKHQKGMPKASFNNESSLRELSGTPNLLNTSDSEQAQKPVSPPGEASTSGQHSRLKLELRRKETEGKMYSLRERKGHAYKEISEPQDDDYLYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPYEGRITEDEEAANSGYSWLITKGRNCYEYVDGKDKSSANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWSGDEYGQELGIRSSIEPAESLGQAVNCWSGMGMSMARNWASSGAASGRKSSWQGENQSQRSIHVPHAVWPFQVKNFSVNMWNAITPLRTSQDHLQENFSNQRIPAQGIRIRSGNILIHAAVMTKPKVKRSKKGPNS
Protein: Ethylene-responsive transcription factor ERF098 (Q9LTC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor bHLH89
- Short-chain dehydrogenase reductase ATA1
- Leucine-rich repeat receptor-like protein kinase TDR
- CLAVATA3/ESR
Sequence:
MESSNRSSNNQSQDDKQARFRGVRRRPWGKFAAEIRDPSRNGARLWLGTFETAEEAARAYDRAAFNLRGHLAILNFPNEYYPRMDDYSLRPPYASSSSSSSSGSTSTNVSRQNQREVFEFEYLDDKVLEELLDSEERKR
Protein: DNA methyltransferase 1-associated protein 1 (Q7ZUN3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTGADVRDILELAGGDNDSGPISKKDIINSDKKKAKKVTETLTFKRPEGMHREVYALLYSDKNRDAPPLLPSDTTQGYRTVKAKLGCKKVRPWKWMPFSNPARKDGAIFHHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQMYLHDDGWTKAETDHLFDLCKRFDLRFIVIHDRYDHQQYRKRSVEDLKERYYCICGKLTKVRAGTGAEPKIYIFDAGHERRRKEQLERLFNRTPEQVAEEEYLVQELRKIETRKREREKKAQDLQKLITAADTTTEMRRAERKATKKKLPQKRETEKPAVPETAGIKFPDFKSAGVSLRSQRMKLPSSVGQKKIKAIEQILTEQGVDLNPMPTEEIVQMFNELRSDLVLVYELKQAYGNCEYEQQMLRHRYDALIKAGGAVTPQSESGGGLDSQSWPCADDIKTEAKEQIIDVVGAPLTPNSRKRRESASSSSSIKKVKKP
Protein: Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) (O88943)
Organism: Rattus norvegicus (Rat)
Function: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2 current is blocked by barium and tetraethylammonium whereas 4-aminopyridine and charybdotoxin have no effect on KCNQ2 current. Tyrosine kinase inhibitors genistein or herbimycin a markedly down-regulate KCNQ2 current. As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11038262, ECO:0000269|PubMed:11230508}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily Q member 5
- ATP-sensitive inward rectifier potassium channel 12
- Potassium voltage-gated channel subfamily KQT member 4
- Potassium voltage-gated channel subfamily KQT member 1
- Inward rectifier potassium channel 4
- ATP-sensitive inward rectifier potassium channel 14
- Inward rectifier potassium channel 2
- Ankyrin-3
- Calmodulin-like protein 4
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
Protein: C-C motif chemokine receptor 7 (J3KSS9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP
Protein: Diheme-cytochrome-encapsulin shell fusion protein (Type 1 encapsulin shell protein) (Q1Q6L7)
Organism: Kuenenia stuttgartiensis
Function: Fusion of the shell and cargo protein of a type 1 encapsulin nanocompartment. Protein missing its signal peptide makes 33 nm particles in E.coli (called cEnc), protein missing its signal peptide and diheme domain (residues 1-86, called Enc) makes 29 nm particles. The cEnc nancompartment encloses c-type heme. The cargo protein NIR-HAO (AC P0DV45) is probably targeted to the nanocompartment by its association with the diheme domain in cEnc; removal of the diheme domain in Enc halves the amount of cargo.
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:28263314}. Note=This type 1 encapsulin nanocompartment may be targeted to the anammoxosome. {ECO:0000305}.
Interaction partners:
Sequence:
MVMGILNTFKKVYAVTGFFALLAVFSLSQVGSSAFAACAKVDDCFSCHTTQELNAVHKNTPYQGQSCIVCHKAFAADDTCSDAKDGRFAKISSEININKEDWNKIQRAVHETTEKHLVGRKFLNIYGPLGTGAQSVPLDTYGLPSWASIDMLGEGNEAIHPLKREIAQIYLIYKDFWLFRRDIEFSKKCETPIDISAAIGAAVSVSRKEDDMVFNGLSEMGIPGLLTASGRNIMKLSDWSVIGNGFQDVVLAVEKLTSRGFNGPFALVVSPKLYAYLHRVYERTGQLEIQGVKELVNGGVYQSYVFNKDVALVIATGSLNMDLAVGSNYKVEYWGPQDLNHRFRVVGSSVLRIKCPQAICTLE
Protein: Myo-inositol transporter 3B (J9VXV2)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Transporter for myo-inositol.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30605}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAILISDVFFTIGAVLIASSYSVPQMIVGRIILGIGVGGAAVIAPLFITETAPTAVRGRCIGVNAFFIPFGQVVADAIGAGVQNVHNGWRLLFALGVVPSVLQLLLFHYLPESPRILILKGDTDRARTVFQSIYPTATRDMIDYKFRVAQEYVAATTALQSETTFWERVKKVWKTGSYRRSITTVSVLQAAGQLCGFNTLLYYAGTLFGLLGLSNPALGGLIPAGTNAVFVLIGMSLVDKVGRRGLMLFGVPIMLLGLVWNIIGFYYLCKPTGGFLDTSYSYDTTNVGVVIGGIVFFVVGYGLTYSHLVWYQAEYLALEVRSMGSGVATTVCWIANLVVSVSYLSELETMTPSGTYGFYLGLSVIGFAFVVFCFPETKQLSIDETSLLFENDWGVKRSVQMRKERRETRKRFQDAELAEAATAHLEARQQKSTSVSPAELSKFMAGLKGNKRKPSVLVKTAT
Protein: Coiled-coil domain-containing protein 15 (Q0P6D6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:37934472}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:37934472}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:37934472}. Note=Localizes to the inner scaffold in the central region of centrioles. {ECO:0000269|PubMed:37934472}.
Interaction partners:
Sequence:
MLGSMARKKPRNTSRLPLALNPLKSKDVLAVLAERNEAIVPVGAWVEPASPGSSEIPAYTSAYLIEEELKEQLRKKQEALKHFQKQVKYRVNQQIRLRKKQQLQKSYERAQKEGSIAMQSSATHLTSKRTSVFPNNLNVAIGSSRLPPSLMPGDGIEDEENQNELFQQQAQALSETMKQARHRLASFKTVIKKKGSVFPDDGRKSFLTREEVLSRKPASTGINTGIRGELPIKVHQGLLAAVPYQNYMENQELDYEEPDYEESSSLVTDEKGKEDLFGRGQQDQQAIHSEDKNKPFSRVQKVKFKNPLFVLMEEEEQKQLHFEGLQDILPEAQDYFLEAQGDLLETQGDLTGIQSVKPDTQAVEMKVQVTEPEGQAIEPEGQPIKTETQGIMLKAQSIELEEGSIVLKTQDFLPTNQALLTKNQDVLLKDHCVLPKDQSILLKYQDQDFLPRDQHVLHKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQNILPKYQGQDFLPKDQDFLSRDQHVLPKDWNILPKCQDQDFLPRDQGVLPKDQNILPICQDQDFLPRDQGYLPKDQNILPICQDRDFLPRDLHVLSNDQNILPKCQDQDFLPKYQKVHFKEPYSDMTDEKGREDFSLADYQCLPPKSQDQDDIKNQQPASFMREERVREELPLDYHQYVVPKIQDQDSPREQNKHIKLPSSFEKWEIARGNTPGVPLAYDRYQSGLSTEFQAPLAFQSDVDKEEDKKERQKQYLRHRRLFMDIEREQVKEQQRQKEQKKKIEKIKKKREQECYAAEQRILRMNFHEDPYSGEKLSEILAQLQLQEIKGTREKQQREKEYLRYVEALRAQIQEKMQLYNITLPPLCCCGPDFWDAHPDTCANNCIFYKNHRAYTRALHSFINSCDVPGGNSTLRVAIHNFASAHRRTLKNL
Protein: GH22493p (Twin of eyg, isoform A) (Q8T0M4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Protein tiptop
- Mitochondrial import inner membrane translocase subunit Tim22
Sequence:
MATSTSPGPTRTTAAIRVSLPGAAPAIPATATAGSQSPGAIMPMAAVPLPSHLQLLGSSAGGVGQPAAITPVSPTAATTVLAQPHSLSPSTPILTQGAPPAAALGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMTLPTASAAAFALSFARQYIAKYMGTPLNLGHGSSPIQAQSGRDHQSEEREYEDEQEEEEVINVEHDAE
Protein: Ras and Rab interactor 3 (Ras interaction/interference protein 3) (Q8TB24)
Organism: Homo sapiens (Human)
Function: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Cytoplasmic vesicle {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Early endosome {ECO:0000269|PubMed:18486601}. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000269|PubMed:18486601}.
Interaction partners:
- Myc box-dependent-interacting protein 1
- CD2-associated protein
- Ras-related protein Rab-5B
- Ras-related protein Rab-5A
- Sodium/potassium/calcium exchanger 4
- Ras-related protein Rab-31
- Thioredoxin domain-containing protein 3
- Cas scaffolding protein family member 4
- Ras and Rab interactor 1
- Zinc finger CW-type PWWP domain protein 1
Sequence:
MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGGSPPCLVVREPNFL
Protein: Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (A0R0W9)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the hydrolysis of alpha,alpha-trehalose into two molecules of D-glucose. Does not hydrolyze maltose, isomaltose, sucrose, cellobiose, p-nitrophenyl-alpha-D-glucopyranoside, and methyl-alpha-D-glucopyranoside. Is also inactive on alpha,beta-trehalose, beta,beta-trehalose, alpha,alpha-trehalose-6,6'-dibehenate, trehalulose, nigerose, and trehalose dimycolate.
Interaction partners:
- Trehalose 6-phosphate phosphatase
- Trehalose synthase/amylase TreS
- Malto-oligosyltrehalose trehalohydrolase
- Glycosyl transferase
- Trehalose-6-phosphate synthase
- Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Sequence:
MVLQQTEPTDGADRKASDGPLTVTAPVPYAAGPTLRNPFPPIADYGFLSDCETTCLISSAGSVEWLCVPRPDSPSVFGAILDRGAGHFRLGPYGVSVPAARRYLPGSLILETTWQTHTGWLIVRDALVMGPWHDIDTRSRTHRRTPMDWDAEHILLRTVRCVSGTVELVMSCEPAFDYHRVSATWEYSGPAYGEAIARASRNPDSHPTLRLTTNLRIGIEGREARARTRLTEGDNVFVALSWSKHPAPQTYEEAADKMWKTSEAWRQWINVGDFPDHPWRAYLQRSALTLKGLTYSPTGALLAAPTTSLPETPQGERNWDYRYSWIRDSTFALWGLYTLGLDREADDFFSFIADVSGANNGERHPLQVMYGVGGERSLVEEELHHLSGYDNSRPVRIGNGAYNQRQHDIWGTMLDSVYLHAKSREQIPDALWPVLKNQVEEAIKHWKEPDRGIWEVRGEPQHFTSSKIMCWVALDRGSKLAELQGEKSYAQQWRAIAEEIKADVLARGVDKRGVLTQRYGDDALDASLLLAVLTRFLPADDPRIRATVLAIADELTEDGLVLRYRVEETDDGLAGEEGTFTICSFWLVSALVEIGEISRAKHLCERLLSFASPLHLYAEEIEPRTGRHLGNFPQAFTHLALINAVVHVIRAEEEADSSGVFVPANAPM
Protein: SD09611p (Q8T9B0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQQQQQQLPIVPGQQQQGPHQHQTLPPNVAHLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSFEETIHRLKVQEAMRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNSGGGGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRVRFSNNRESTGVISLRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTSMASCICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIAGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESNSLDDVVTKCSSEIMKRVESARRCKDNPFKTTLPGGGRLGKKSFLGGNGLMADDTLTRGGLSEKSSDSGVSSSSLSSGPLKSST
Protein: Putative anti-FlhC(2)FlhD(4) factor YdiV (c-di-GMP regulator CdgR) (P76204)
Organism: Escherichia coli (strain K12)
Function: Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC.
Interaction partners:
- Flagellar transcriptional regulator FlhD
- Regulator of sigma S factor FliZ
- Blue light- and temperature-regulated antirepressor BluF
Sequence:
MKIFLENLYHSDCYFLPIRDNQQVLVGVELITHFSSEDGTVRIPTSRVIAQLTEEQHWQLFSEQLELLKSCQHFFIQHKLFAWLNLTPQVATLLLERDNYAGELLKYPFIELLINENYPHLNEGKDNRGLLSLSQVYPLVLGNLGAGNSTMKAVFDGLFTRVMLDKSFIQQQITHRSFEPFIRAIQAQISPCCNCIIAGGIDTAEILAQITPFDFHALQGCLWPAVPINQITTLVQR
Protein: Sp1 transcription factor (Transcription factor Sp1) (F1QW97)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- E1A-binding protein p300 b.
- Cellular tumor antigen p53
- Estrogen receptor
- E1A-binding protein p300 a.
- Upstream stimulatory factor 1
- Upstream stimulatory factor 2
- E2F transcription factor 1.
- Zinc finger protein 143a.
- Mediator of RNA polymerase II transcription subunit 1
- Mothers against decapentaplegic homolog
Sequence:
MSDLKKREKLAPSHRMSDPQKSSMADSEPGFPQKSSSSSAQDSQQPSPLALLAATCSRIDENGAAEPQTRQDSQLELPQGTNGWHISPAGTQTPTSAPAAVPTAPSEERSRAATATIQPQFLMPAQSQQLLTALPGVMPNIQYQVIPQFQTVDGQQLQLQAAQDMSGQLLVSSPGGQQLRAAGSGNILTVPGLFQQAIPLQNLSAVLPNQTQFLANVPLNANITLLPVGPGPVGGDTHTAVAAPPQGPEFCSTASSTRATAAVGIATLAQSRAPAASDGQKGQPQMLLQGVQQGAVSAPGPVFTTQTLSQDGVQNVQIQTIASGSPILIRTLGADGQVSWQTLQLQSPGAQITLAPTGASGPVQLSGLQTINLNTLGSGGLQMQPIQMPVTIASAPGEAAADALEDSAVLEENAESSPNTASSRRTRREACTCPYCKDGEGRDPSKKKQHICHIPGCGKVYGKTSHLRAHLRWHTGERPFVCSWSFCGKRFTRSDELQRHKRTHTGEKKFSCTECPKRFMRSDHLSKHIKTHLNKKVCVSACSDPVTPAADADPQTLLTVDSLSADSFTRLPGGISVMQVTDLQSIGLSGSNGF
Protein: CRISPR system Cms protein Csm5 (CRISPR type III A-associated protein Csm5) (P9WJF5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions.
Interaction partners:
- CRISPR system Cms protein Csm4
- CRISPR system Cms endoribonuclease Csm3
- CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1
- CRISPR system Cms protein Csm2
- CRISPR-associated endoribonuclease Cas6
- CRISPR system endoribonuclease Csm6
- CRISPR-associated endoribonuclease Cas2
- Uncharacterized protein
- PPE family protein PPE44
- PPE family protein PPE56
Sequence:
MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE
Protein: Polycomb group protein VERNALIZATION 2 (Q8W5B1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Polycomb group (PcG) protein. Plays a central role in vernalization by maintaining repressed the homeotic gene FLC, a floral repressor, after a cold treatment. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Associates constitutively along the whole FLC locus.
Subcellular location: Nucleus.
Interaction partners:
- Histone-lysine N-methyltransferase CLF
- Histone-lysine N-methyltransferase EZA1
- Protein VERNALIZATION INSENSITIVE 3
- Histone-binding protein MSI1
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- VIN3-like protein 1
- VIN3-like protein 2
- B3 domain-containing transcription factor VRN1
- Histone-lysine N-methyltransferase MEDEA
- Lysine-specific demethylase ELF6
Sequence:
MCRQNCRAKSSPEEVISTDENLLIYCKPVRLYNIFHLRSLGNPSFLPRCLNYKIGAKRKRKSRSTGMVVFNYKDCNNTLQRTEVREDCSCPFCSMLCGSFKGLQFHLNSSHDLFEFEFKLLEEYQTVNVSVKLNSFIFEEEGSDDDKFEPFSLCSKPRKRRQRGGRNNTRRLKVCFLPLDSPSLANGTENGIALLNDGNRGLGYPEATELAGQFEMTSNIPPAIAHSSLDAGAKVILTTEAVVPATKTRKLSAERSEARSHLLLQKRQFYHSHRVQPMALEQVMSDRDSEDEVDDDVADFEDRQMLDDFVDVNKDEKQFMHLWNSFVRKQRVIADGHISWACEVFSRFYEKELHCYSSLFWCWRLFLIKLWNHGLVDSATINNCNTILENCRNTSVTNNNNNSVDHPSDSNTNNNNIVDHPNDIKNKNNVDNKDNNSRDK