wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription initiation factor TFIID subunit 6 (TBP-associated factor 6) (TBP-associated factor 60 kDa) (TAFII-60) (TAFII60) (P53040)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID and the regulatory transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
Subcellular location: Nucleus.
Interaction partners:
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 8
- SAGA complex/transcription factor TFIID complex subunit TAF5
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 4
- Transcription initiation factor TFIID subunit 2
- SAGA complex subunit HFI1
- Transcription initiation factor TFIID subunit 1
- SAGA complex subunit SPT8
- SAGA complex subunit SGF29
Sequence:
MSTQQQSYTIWSPQDTVKDVAESLGLENINDDVLKALAMDVEYRILEIIEQAVKFKRHSKRDVLTTDDVSKALRVLNVEPLYGYYDGSEVNKAVSFSKVNTSGGQSVYYLDEEEVDFDRLINEPLPQVPRLPTFTTHWLAVEGVQPAIIQNPNLNDIRVSQPPFIRGAIVTALNDNSLQTPVTSTTASASVTDTGASQHLSNVKPGQNTEVKPLVKHVLSKELQIYFNKVISTLTAKSQADEAAQHMKQAALTSLRTDSGLHQLVPYFIQFIAEQITQNLSDLQLLTTILEMIYSLLSNTSIFLDPYIHSLMPSILTLLLAKKLGGSPKDDSPQEIHEFLERTNALRDFAASLLDYVLKKFPQAYKSLKPRVTRTLLKTFLDINRVFGTYYGCLKGVSVLEGESIRFFLGNLNNWARLVFNESGITLDNIEEHLNDDSNPTRTKFTKEETQILVDTVISALLVLKKDLPDLYEGKGEKVTDEDKEKLLERCGVTIGFHILKRDDAKELISAIFFGE
Protein: Mesoderm induction early response protein 2 (Mi-er2) (Q8N344)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Interaction partners:
- Histone deacetylase 2
- Chromodomain Y-like protein
- Transcription factor Dp-1
- Transcription factor E2F6
- Lethal
Sequence:
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSASSDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEEFLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDGLPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKELPLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHCNVMTC
Protein: Protein FAM110A (Q8R184)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles. {ECO:0000250}.
Interaction partners:
Sequence:
MPVDTLSPGAPATPALPFRLRTKVPGYLLPRPADGGARKPSAVERLEADKAKYVKSLRVANTRQEPVQPPLVRQPLFSPGPRGPVLTPSRRVLPCSGRRPQLDLDILSSLINLCDSPVSPSEASRTPGRPEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPARPYPSPGTTTTSSPGRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSRRSSATVEERSLDRVPYGVSVIERNARVIKWLYGLRQARDPPTTEG
Protein: Glutathione hydrolase 6 (EC 3.4.19.13) (Gamma-glutamyltransferase 6) (GGT 6) (EC 2.3.2.2) (Gamma-glutamyltranspeptidase 6) [Cleaved into: Glutathione hydrolase 6 heavy chain; Glutathione hydrolase 6 light chain] (Q6P531)
Organism: Homo sapiens (Human)
Function: Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}.
Interaction partners:
- Glutathione synthetase
- Glutathione hydrolase 5 proenzyme
- Aminopeptidase N
- Glutathione hydrolase 1 proenzyme
- Glutathione hydrolase 7
- Glutamate--cysteine ligase catalytic subunit
- Gamma-glutamylcyclotransferase
- Cytosol aminopeptidase
- Glutathione reductase, mitochondrial
- 5-oxoprolinase
Sequence:
MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQDSSRNKAGGLPGTWARVVAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGPGVYHHGAIISPAGRELLVAGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLFHDSSSGNSTALTSGPAQTLAPGLGLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGTEGLCPLLCHADGTPLGAGARATNPQLAAVLRSAALAPTSDLAGDALLSLLAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPSPSAGPELLALLEAALRSGAPIPDPCPPFLQTAVSPESSALAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSNLVAKSTTSAWACPLILRGSLDDTEADVLGLVASGTPDVARAMTHTLLRHLAARPPTQAQHQHQGQQEPTEHPSTCGQGTLLQVAAHTEHAHVSSVPHACCPFQGF
Protein: Transcriptional regulator (Q0PB47)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Interaction partners:
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit alpha
- Glutamate synthase large chain
- RNA polymerase sigma factor SigA
- Transmembrane protein
- Lipoprotein
- Membrane protein
- DNA-directed RNA polymerase subunit omega
Sequence:
MKDYLELLSSVGKLKKFQKNSILFYEGEEAKNFFILLKGKIRIYKSTASDKEITLHYFNPPNFIAEMPAFKKLNYPANAVFEEDGEILEIDFINFQNLCSENKEFNFLLISSLFDKIKILEKKLSQNALDLRTRLLKYLLENEKNLDTISQKQIAIDLNVRAQSLSRVLKELKISELIDTKKGRIEILNKDMIMKELW
Protein: ABC transporter G family member 13 (ABC transporter ABCG.13) (AtABCG13) (White-brown complex homolog protein 13) (AtWBC13) (Q9C8J8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Non-specific lipid transfer protein GPI-anchored 2
Sequence:
MTTPEGAMYVAWEDLTVVIPNFGEGATKRLLNGVNGCGEPNRILAIMGPSGSGKSTLLDALAGRLAGNVVMSGKVLVNGKKRRLDFGAAAYVTQEDVLLGTLTVRESISYSAHLRLPSKLTREEISDIVEATITDMGLEECSDRTIGNWHLRGISGGEKKRLSIALEVLTKPSLLFLDEPTSGLDSASAFFVVQILRNIASSGKTVVSSIHQPSGEVFALFDDLLLLSGGETVYFGEAESATKFFGEAGFPCPSRRNPSDHFLRCVNSDFDNVTAALVESRRINDSSFSLHQLHETTNTLDPLDDIPTAEIRTTLVRKFKCSLYAAASRARIQEIASIVGIVTERKKGSQTNWWKQLRILTQRSFINMSRDLGYYWMRIAVYIVLSICVGSIFFNVGRNHTNVMSTAACGGFMAGFMTFMSIGGFQSFIEEMKVFSRERLNGHYGVAVYTVSNLLSSLPFIILMCLSTSSITIYMVRFQSGGSHFFYNCLDLICAITTVESCMMMIASVVPNFLMGVMLGAGYIGIMVLSAGFFRFFPDLPMVFWRYPVSYINYGAWALQGAYKNEMIGVEYDSPLPLVPKMKGELILQTVLGINPESSKWLDLAVVMMILIGYRIAFFAILKFREKVFPVIHMLYTKRTLSHIQKRPSFRRMTPFPSRRYPVHHALSSQEGLNSPLH
Protein: Nbp2p (Q5AGV0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Mto2p-binding domain-containing protein
Sequence:
MTSHFPPNTKIKDFGYPETHPFHIGNYLLKSNGSISSSPTSSTTSSSASSSSTTSSSAFISNKHGNHHHHHHHHHLPNNYMTNSSQFISSNDYNNTNNINDDDDDDDDNDNDDDIIDDDYDQDEINCKARAIFDFSAENDNEISLIEGQIIWISYRHGQGWLVAEDPISGENGLVPEEYVEIMQNLDNKNKKKHKNKSININGDYQEFGHQYGNASNNQDEDVPKRFLPEIFNDHIHQDDDDDNVDCDSEWVDTDYEEEEEEEEEEEEEEEAEEEQEQEKQQPQEGKEEPKMEIAKLEQPVNKESEINGETITTTTATITTTTTTTIEKINAIEKKLNDVEI
Protein: Putative rho GDP-dissociation inhibitor 1 (Q95UQ1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole. Required for efficient accumulation of cap at the cell cortex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19010323}.
Interaction partners:
- Rho-related protein rac1A
- Rho-related protein racD
- Putative rho GDP-dissociation inhibitor 2
- Rho-related protein racB
- Rho-related protein rac1B
- Rho-related protein racC
- Rho GTPase
- Rho-related protein racH
- Rho-related protein racO
- Rho-related protein racI
Sequence:
MSDNHEEESNVPAYVPGKHVSVDQLKQQDAEDEALKRYKESLLGTGVHAPKDDPRKLVIKEMKIQIEGRPDTIYPLDTKELIKEMKTKPFVLKESCHYKITLTFNIQHDIVSGLKQTNTVYRKGIKVSTEKHMLGSFAPQALAHSVTNPRHGWEEAPSGMLARGSYTAKVVFTDDDNEEHLSVEYAFSIKSDWKSDD
Protein: Zinc finger CCCH domain-containing protein 29 (AtC3H29) (AtSZF2) (Q9XEE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in salt stress response. May positively modulate plant tolerance to salt stress.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein ZAT10
- Zinc finger protein ZAT12
- Heat stress transcription factor C-1
- At2g39650
- At2g01260
- Zinc finger CCCH domain-containing protein 37
- Zinc finger CCCH domain-containing protein 15
- Zinc finger CCCH domain-containing protein 14
- NAC domain-containing protein 62
- Zinc finger protein ZAT6
Sequence:
MCGAKSNLCSSKTLTEVEFMRQKSEDGASATCLLEFAACDDLSSFKREIEENPSVEIDESGFWYCRRVGSKKMGFEERTPLMVAAMYGSMEVLNYIIATGRSDVNRVCSDEKVTALHCAVSGCSVSIVEIIKILLDASASPNCVDANGNKPVDLLAKDSRFVPNQSRKAVEVLLTGIHGSVMEEEEEELKSVVTKYPADASLPDINEGVYGTDDFRMFSFKVKPCSRAYSHDWTECPFVHPGENARRRDPRKYPYTCVPCPEFRKGSCPKGDSCEYAHGVFESWLHPAQYRTRLCKDETGCARRVCFFAHRRDELRPVNASTGSAMVSPRSSNQSPEMSVMSPLTLGSSPMNSPMANGVPLSPRNGGLWQNRVNSLTPPPLQLNGSRLKSTLSARDMDMEMELRFRGLDNRRLGDLKPSNLEETFGSYDSASVMQLQSPSRHSQMNHYPSSPVRQPPPHGFESSAAMAAAVMNARSSAFAKRSLSFKPAPVASNVSDWGSPNGKLEWGMQRDELNKLRRSASFGIHGNNNNSVSRPARDYSDEPDVSWVNSLVKENAPERVNERVGNTVNGAASRDKFKLPSWAEQMYIDHEQQIVA
Protein: Voltage-gated inwardly rectifying potassium channel KCNH2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (RERG) (r-ERG) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) (O08962)
Organism: Rattus norvegicus (Rat)
Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium voltage-gated channel subfamily E member 2
- Potassium voltage-gated channel subfamily KQT member 1
- Sodium channel protein type 5 subunit alpha
- Potassium voltage-gated channel subfamily E member 3
- Potassium channel subfamily K member 1
- Potassium voltage-gated channel subfamily E regulatory subunit 5
- Potassium voltage-gated channel subfamily E member 1
- Voltage-dependent L-type calcium channel subunit alpha-1C
- A-type voltage-gated potassium channel KCND3
- Inward rectifier potassium channel 2
Sequence:
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS
Protein: Hereditary hemochromatosis protein homolog (RT1-CAFE) (O35799)
Organism: Rattus norvegicus (Rat)
Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q30201}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q30201}.
Interaction partners:
- Transferrin receptor protein 1
- Transferrin receptor protein 2
- Beta-2-microglobulin
- Hemojuvelin
- Hepcidin
- Transmembrane protease serine 6
- Bone morphogenetic protein 6
- Natural resistance-associated macrophage protein 2
- Ferroportin
- Plasma membrane ascorbate-dependent reductase CYBRD1
Sequence:
MDRSAGLPVRLLLLLLLLLLWSVAPQALRPGSHSLRYLFMGASKPDLGLPFFEALGYVDDQLFVSYNHESRRAEPRAPWILGQTSSQLWLQLSQSLKGWDYMFIVDFWTIMGNYNHSKVTKLRVVPESHILQVILGCEVHEDNSTSGFWKYGYDGQDHLEFCPKTLNWSAAEPRAWATKMEWEEHRIRARQSRDYLQRDCPQQLKQVLELQRGVLGQQVPTLVKVTRHWASTGTSLRCQALNFFPQNITMRWLKDSQPLDAKDVNPENVLPNGDGTYQGWLTLAVAPGEETRFSCQVEHPGLDQPLTATWEPSRSQDMIIGIISGITICAIFFVGILILVLRKRKVSGGTMGDYVLTECE
Protein: Lysophospholipid acyltransferase 5 (LPLAT 5) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) (Protein nessy) (Nes) (Q9VVX5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acyltransferase that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids). Highest activity with lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) producing phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), but also converts lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has a preference for unsaturated fatty acids of at least 16 carbons such as oleoyl-CoA ((9Z)-octadecenoyl-CoA) and palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA). Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature. Essential for fertility and viability together with Oysgedart (Oys). Required for germ cells to migrate into the mesoderm.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:19864461}. Membrane {ECO:0000269|PubMed:19864461}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Lysophosphatidylcholine acyltransferase
- FI05338p
- GH11618p
- GM01519p
- LD39232p1
- Neuropathy target esterase sws
- Phosphatidylserine synthase
- Phospholipase
- BcDNA.GH02384
- Uncharacterized protein, isoform A
Sequence:
MAEFEEDLPHNGLMDGIASGVGVPVEALRLLLTILAGYPVAALYQKFISVIADKTVHHMFFAGCGAGLCYFNYGLDTYHSLIAILTTYFLVLLLRKKTQIFLAINFVFHMSYLLLGYFYTSSNDYDILWTMPHCILVLRMIGYGFDITDGLKEESELSKDQKETALKKPPSLLELLAFSYFPSGFLVGPQFPFRRYKAFVDGEFRQHEGNVEAGVRRFGAGAFYLIVCQVGLRYLPDSYFLTPEFAQVSFVKRIYLLGFWAKFSLYKYISCWLLTEGALICIGLTYKGEDKNGQPDWSGCSNVKLKLLETGNTMEHYVQSFNVNTNQWVGQYIYKRLKFLNNRTISYGAALGFLAVWHGYHSGYYMTFLMEYMVVSTEKQITRFYTKVVLPQWGHILNNSDIYKLLYFITLKSYNVVYMGWCLTAFVFLKYERWIVVYGAVSYYGFTFLVLWAAFYHTFNHFFRSSSRKLAGEDQKLQDSNTDKLVEEKKPEDKKSE
Protein: Mitogen-activated protein (MAP) kinase kinase kinase (Eurofung) (C8V9T1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Mitogen-activated protein kinase kinae mkk2
- protein kinase C
- MAP kinase kinase
- mitogen-activated protein kinase
- GTP binding protein
- mitogen-activated protein kinase kinase
- Protein kinase domain-containing protein
- ZZ type zinc finger domain protein
- TRAF-like signal transducer, putative
- MAPKKK cascade protein kinase regulator Ste50
Sequence:
MDGQRQQPYVPAPPPSASQPSQAHIMPLPPPPPRYPPAQPQNVMPPPPPGPPPGSAYGTSKLTNPQLQSQSTLGWSNWGGRGIPQYLPPPPPPPMTHANQSSFARPSAVQNNNATSATYVPQPGTFGPGVGIPPFDVPSHSYDAPNTMVASERPRPPPNAPYGHGTSNASAYQLDGTIPSTPLTHTAPFSHETSHDVPSSAVPTGSPFKSVPQSASQANDLTKSSSHRHNNSNTTVGGMSASEAAVQWPLDRVLLWLAKNGFSHEWQETFKTLEIEGADFLELGHGQNGRPNLGKMHTVVYPQLAKECEANGTAFDLTRERDEGKRMRKLIRLIHDDAGPDNGGTFNKQHDFDDGHGSVPDEGPEFSPNINNVAQAPGSPSLNATNVSNSPNLKAPKYSHKPRSFTTPGSISHDSTTAELAMTEGSSTMLPRSDFSRNVLGTIGIDHQRKSPSMSSDNGVFAIPPHRPHEGSPKSGSPAAQHATLYAAPVSSATDLNAKYDARFGHNRVNSGERRYYETLKHDGSRPSPQTTQTAGDNASSYPKDHRMGFLNFFKKKSARNSDPNNPSPDDNTPDSPIYSKYHFNSSDVSVNERPLSASLSDYERMMMVRTKPAHRGKRFIFATMDGWNYRLIDTTDIDSVEKLRASICQNLGIYDWPDAQIFLTEPGQLEHDEPLNDTFLTLCQRSKSDSIGSLKLFVKTPHNVAGLGVSMPDRSAVSPTSAIPRKPLDGEAASRLSPLKPSSPQQLKPPASRLPLRDIQNSAAGTSPVDGEPDGSLQDQERKPQKSYRPTPAPLPRPDAYSETGYRRKEVINFDKPRISPYEDKKSEVLVPFRKPPSAPQESNTLSKVNSLRKKDGDRPRPHRSNQPPGIKEMMADMGMMSSLIGKPSSPNSGNTTATEDAHSSIDSAVDKSSQSTPPLTNTSYSPTTTATTTTTTTTASSSLSRSASQKRKSVGPEFDFEETQVSFQRSPALEEDSDDDSDDGLFAIPLANTKNSVKPGSPDTQARPRKPSLTVDTEAKPRTGLSVSFKSPSATRETFASSGGDASNSTAPYFIASNSPEEEKTPIRRNSLRNSFATGDVWASRPPVEGVIDQLDDFFPDIDLDAPYLDEQGTSPPSSPASKVAIDNELNRKDKQENSHHGMQPPPAPEDNTLGSSEPTMTSHGQGIVARRNVSRSGGGLTRMKSIREVAKGANQATRQRSVAASSGNKRSGDVHRRKSTKMFGAKIMQISPRRGSQLSQLDPIPQNSISSSSKPQRQPTFRIIRGQLIGKGTYGRVYLGMNADNGEVLAVKQVEINPRLAGQDTDKIKEMVAALDQEIDTMQHLEHPNIVQYLGCERGELSISIYLEYISGGSIGSCLRKHGKFEESVVKSLTRQTLEGLSYLHNQGILHRDLKADNILLDLDGTCKISDFGISKKSNDIYGNDSSNSMQGSVFWMAPEVIQSQGQGYSAKVDIWSLGCVVLEMFAGRRPWSKEEAIGAIFKLGSLSQAPPIPDDVSMNVTPAALAFMWDCFTVDTSERPTAQTLLTHPFCEPDPKYNFLDTELYAKIRPVLEN
Protein: NACHT, LRR and PYD domains-containing protein 1b allele 4 (Q2LKV2)
Organism: Mus musculus (Mouse)
Function: Probable inactive allele of Nlrp1b, which lacks a CARD domain, suggesting that it is not able to form an inflammasome. Contrary to Nlrp1b allele 1, allele 4 is not activated by B.anthracis lethal toxin and no other activation signal is reported.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9C000}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9C000}.
Interaction partners:
Sequence:
MEESPPKQKSNTKVAQHEGQQDLNTTRHMNVELKHRPKLERHLKLGMIPVVYMKQREEILYPAQSLKEENLIQNFTSLPLLQKLCPKDPENMVRKSWASCIPEEGGHMINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARLVKRAWKEGQLYRDHFQHVFFFSCRELAQCKKLSLAELIAQGQEVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCLHWSQRQPVHTLLGSLLGKSILPEAFFLLTTRTTALQKFIPSLPMPCQVEVLGFSGIEWENYFYKYFANQRHAITAFMMVESNPVLLTLCEVPWVCWLVCTCLKKQMKQGRVLSLKSQTTTALCLKYLSLTIPDKHRRTQVKALCSLAAEGIWKRRTLFSESDLCKQGLDEDAVATFLKTGVLQKQASSLSYSFAHLCLQEFFAAISCILEDSEERHGNMEMDRIVETLVERYGRQNLFEAPTVRFLFGLLGKEGVKGMEKLFSCSLPGKTKLKLLWHILGKSQPHQPPCLGLLHCLYENQDMELLTHVMHDLQGTIVPGPNDIAHTVLQTNVKQLVVQTDMELMVATFCIQFYCHVRTLQLNMEKQQGYALTSPRMVLYRWTPITNASWEILFYNLKFTRNLEGLDLSGNSLRYSVVQSLCNTLRYPGCQLKTLWLVKCGLTSRYCSLLASVLSAHSSLTELYLQLNDLGDDGVRMLCEGLRNPVCNLSILWLDLSSLSAQVITELRTLEEKNPKLYIRSIWMPHMMVPTENMDEEAILTTFKQQRQESGDKPMEILGTEEDFWGPTGPVATELVDRVRNLYRVQLPMAGSYHCPSTGLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTEASTFDFKVTHFQEHGSRNAR
Protein: Protein IMPACT homolog (P25637)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis. In normal conditions, it resides in a actin complex and has no activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein GIR2
- Putative ATP-dependent RNA helicase YLR419W
- eIF-2-alpha kinase activator GCN1
Sequence:
MDDDHEQLVEELEAVEAIYPDLLSKKQEDGSIIVVKVPQHEYMTLQISFPTHYPSEEAPNVIEVGVCTSLAKRDLYDTKYLQHLFQEVMDSVFHRGSVCLFDFLTELDGVLYVEPEEETEPVQQSDIPTDPFEGWTASDPITDRGSTFMAFAAHVTSEEQAFAMLDLLKTDSKMRKANHVMSAWRIKQDGSAATYQDSDDDGETAAGSRMLHLITIMDVWNVIVVVARWFGGAHIGPDRFKHINSTAREAVVRAGFDS
Protein: Cadherin-17 (Liver-intestine cadherin) (LI-cadherin) (P55281)
Organism: Rattus norvegicus (Rat)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Catenin delta 1
- Catenin beta-1
Sequence:
MVSAQLHFLCLLTLYLTGAYGQEGKFSGPLKPMTFSIFEGQEPSQIIFQFKANPPAVTFELTGETDGIFKIEKDGLLYHTRVLDRETRAVHHLQLAALDSQGAIVDGPVPIIIEVKDINDNRPTFLQTKYEGSVRQNSRPGKPFMYVNATDLDDPATPNGQLFYQIVIQLPKINNVMYFQIDNKTGAISLTPEGSQVLDPIKNPYYNLVVSVKDMGGQNENSFSDTTSVDITVRENIWKAPEPVEIRENLTDPHPIKITQVQWNDPGAHYSLINKEKLPQFPFSIDQEGNIYVTQPLDREEKDSHVFFATAKDENGKPLAYPLEIRVKVIDINDNPPTCLSQVTVFEVQENEVLGSSIGIFAAHDMDEANNINSILKYRLVDQTPKVPSDELFLIDEYGGKVQLGKRSLKKQDSPQYNLTVEVSDIDFKTLCSLQVNVIDINDQIPIFERSDYGSKTLSEDTAIGSTILIIQATDDDEPFTGSSKILYKIVQGDTEGRLEVVTDPMTNTGYVKIRKPLDFETEPVTSIVFKAENPEPLVNGIEYNASSFASFELTVTDVNEVPVFPQQIFQANVSEDTAIGTKVGTVTARDPEGLTVSYSLKDNKRGWLKIDSVTGDIFSTAPLDRETESVYRVQVVATEVGGSSLSSTAYFHLVLMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQQSVRRPKFTFALGRESLQSDWEVSKINGTHARLSTKHTRFEEQVYDIPILINDGGQPPMEGIVSLSVTFCQCVDGSCFRPAGNQVGIPTVGMAVGILLTTFLVIGIILAVVFIRMRKDKVEDPQSPENKPLRS
Protein: Protein transport protein YIP1 (YPT-interacting protein 1) (P53039)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport, probably by mediating correct membrane localization of YPT1.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Interaction partners:
- Protein transport protein YIF1
- GTP-binding protein YPT1
- Protein YIP5
- GTP-binding protein YPT31/YPT8
- Protein transport protein YOS1
- Protein YIP4
- Prenylated Rab acceptor 1
- Protein YOP1
- Protein transport protein SEC23
- Protein transport protein SEC13
Sequence:
MSFYNTSNNANNGGGFYQPSAQFAVPQGSMSFQNTVGSSNTGNDNNLGVAPDPLPVGILHALSTKGYPHEPPLLEEIGINFDHIITKTKMVLIPIRFGSGVPQEILNDSDLAGPLIFFLLFGLFLLMAGKVHFGYIYGVALFGTISLHNLSKLMSNNDTSTQTNLQFFNTASILGYCFLPLCFLSLLGIFHGLNNTTGYVVSVLFVIWSTWTSSGFLNSLLQLQNARLLIAYPLLIFYSVFALMVIFV
Protein: Transcription factor GHD7 (Protein GRAIN NUMBER PLANT HEIGHT AND HEADING DATE 7) (E5RQA1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor involved in the regulation of flowering time under long day (LD) conditions. Plays a major role as repressor of flowering. Controls flowering time by negatively regulating the expression of EHD1 and HD3A.
Subcellular location: Nucleus {ECO:0000269|PubMed:18454147}.
Interaction partners:
- Nuclear transcription factor Y subunit B-11
Sequence:
MSMGPAAGEGCGLCGADGGGCCSRHRHDDDGFPFVFPPSACQGIGAPAPPVHEFQFFGNDGGGDDGESVAWLFDDYPPPSPVAAAAGMHHRQPPYDGVVAPPSLFRRNTGAGGLTFDVSLGERPDLDAGLGLGGGGGRHAEAAASATIMSYCGSTFTDAASSMPKEMVAAMADDGESLNPNTVVGAMVEREAKLMRYKEKRKKRCYEKQIRYASRKAYAEMRPRVRGRFAKEPDQEAVAPPSTYVDPSRLELGQWFR