wanglab/gogpt-training-data huggingface dataset:
Protein: RNA polymerase II subunit A C-terminal domain phosphatase ssup-72 (CTD phosphatase ssup-72) (EC 3.1.3.16) (Q22453)
Organism: Caenorhabditis elegans
Function: Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1. By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre-mRNAs, including unc-44 and dlk-1 mRNAs. This results in the tissue-specific expression of unc-44 isoforms.
Subcellular location: Nucleus {ECO:0000269|PubMed:26588990}.
Interaction partners:
- pre-mRNA 3' end processing protein pfs-2
- DUF3453 domain-containing protein
- Cleavage and polyadenylation specificity factor subunit 4
- Polyadenylation and cleavage factor homolog 11
- Probable cleavage and polyadenylation specificity factor subunit 2
- Probable cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 3
- Pre-mRNA polyadenylation factor Fip1 domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MEYSSKLRFAVSCSSNMNRSMEAHGILKKRGFNIESYGSGNQVKMPGPTVDKPNCYEFGPTTYEDIYADLTNKDLHLYTQNGLLHMVDRNRRIKSRPQRFQAETREFDIVLCLEERVFDQVVDFLNRSVGKSGNPVHVINIDIEDNAEEATFGAFFVADLCEKLERSEDFEEDIDQIITDLEENNPKRNLLHTICFY
Protein: SWM histone demethylase complex subunit phf1 (PHD finger domain-containing protein phf1) (P87233)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Lysine-specific histone demethylase 1
- Lysine-specific histone demethylase 2
- SWM histone demethylase complex subunit phf2
- Switch-activating protein 1
Sequence:
MSQKNFFDEGKSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVFCDGCNSPYHQLCHHPPIDDATVQDVDAEWFCMKCQYRRAKQPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRSGSIYQIATVEEYPHLQPSLLPTFQRNRKVPKLVPVSFPTDDPQNLCATVL
Protein: Protein kinase, putative (EC 2.7.1.-) (Q382T9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase, putative
Sequence:
MASYIASNVNSSTIAKGMSGDTAGFYGSSTTAMVPPPVVIASKTNHPKNQQYQSTFQADERGITHPRRSASKRDRDNGIEQPSAIDQSATAANNSADSAVTPKSAHGVTSYASNKKKKVTYALPNQSREEGHFYVVLGEDIDASTGRFKILSLLGEGTFGKVVEAWDRKRKEYCAVKIVRNVPKYTRDAKIEIQFMERVRLSDVEDRFPLMKIQRYFQNETGHMCIVMPKYGPCLLDWIMKHGPFNHRHLAQIIFQVGAALDYFHTELHLMHTDLKPENILMESGDTSVDPMTHRALPPEPCRVRICDLGGCCDERHSRTAIVSTRHYRSPEVVLSLGWMYSTDLWSMGCIIYELYTGKLLYDTHDNLEHLHLMEKTLGRLPADWSVRCGTQEARDLFTAAGTLQPCKDPKHIARIARARPVREVITEPLLCDLILNLLHYDRQRRLNARQMMSHAYVHKYFPECRQHPNHVDNRSKLPPTPVM
Protein: N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic (EC 5.3.1.24) (Q8LPI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- indole-3-glycerol-phosphate synthase
- Indole-3-glycerol phosphate synthase, chloroplastic
- Anthranilate phosphoribosyltransferase, chloroplastic
- Anthranilate phosphoribosyltransferase
- Tryptophan synthase
- anthranilate synthase
- tryptophan synthase
- Tryptophan synthase alpha chain
- Tryptophan synthase alpha chain, chloroplastic
- Anthranilate synthase beta subunit 2, chloroplastic
Sequence:
MSTGISSDLHLHPRALNFSKTSKSGLSNRKVSFSSVGYAQNRKLSCSVSSTENVAPKDDDRGKDRPLVKMCGITSARDAAMAVEAGADFIGMIIWPHSKRSISLSVAKDISQVAREGGAKPVGVFVEDDENTILRAADSSDLELVQLHGNSSRAAFSRLVRERKVIYVLNANEDGKLLNVVPEEDGHLADWILVDSATGGRYLDQLLSFFALSHCNVFLRGTSYTITLVHETVCLSQVTEISRV
Protein: RCK N-terminal domain-containing protein (Q57WI2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQEDVKHLLCGVVDGSCVDPTMNPLITGAPLAVSALAQQCLYTCYAVSSNHAVIGDKSSNFWRVLRYVERVRDKYVESETLPPPPPLRLRNSCTYETTGGDNSAAAGACGSEIGGIGGVVFKVAPSCSDLETSDQSFHYSPLAPFKQGRVRKQLLPPLEFRVVVVGGGRVGRAIVELLLRVRELVHPSRVTIVTQRPEAVACFAAQGVQCVAKDAGRQALMQCHVLIIACQQSQFHDFAKIYCPRCSLTPAAVGLVDNEAAGGSRTDEVDEVGGAVKDRRRPRKRTLRDVVEKWRTMETSERGSSRKNVKDSPGESSRKDEPLTRLLRPDAIVFSCCVALPAHKIASDLGHLYPLVVRARINLKSVRGLAQDIQTVKAVLHDDYVKRLQSEGNTFLTRLTLIQQSAKGGGKQAELLRLVKAAHERHGDLTSSNLSGGMGNTLESLPCLGLGDSFARMDSTNPLQSRQSKGGGVLDLKNMLPTTNNENPMFVVHMWRALRSLSVVQALNFTRTDQRSFIYLGSMGPLLACTLVALPTNTQRAIVSGIETYLDDSFRYYQNRVATDGVNDDDIAPFILLRVNQRHVPAFDSDDDEDEGCGSSSPTEETLTPAQPFLERELRRLVARFPTVFKSTKIVLQQLLSVYKMVACSANSP
Protein: Osmosensing histidine protein kinase SLN1 (EC 2.7.13.3) (Osmolarity two-component system protein SLN1) (Tyrosine phosphatase-dependent protein 2) (P39928)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Histidine kinase that acts as an osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphorelay intermediate protein YPD1
- MAP kinase kinase kinase SSK2
- Mitogen-activated protein kinase HOG1
- High osmolarity signaling protein SHO1
- MAP kinase kinase PBS2
- Serine/threonine-protein kinase SSK22
- Initiation-specific alpha-1,6-mannosyltransferase
- Osmolarity two-component system protein SSK1
- Serine/threonine-protein kinase STE11
- Signaling mucin HKR1
Sequence:
MRFGLPSKLELTPPFRIGIRTQLTALVSIVALGSLIILAVTTGVYFTSNYKNLRSDRLYIAAQLKSSQIDQTLNYLYYQAYYLASRDALQSSLTSYVAGNKSADNWVDSLSVIQKFLSSSNLFYVAKVYDSSFNAVLNATNNGTGDLIPEDVLDSLFPLSTDTPLPSSLETIGILTDPVLNSTDYLMSMSLPIFANPSIILTDSRVYGYITIIMSAEGLKSVFNDTTALEHSTIAIISAVYNSQGKASGYHFVFPPYGSRSDLPQKVFSIKNDTFISSAFRNGKGGSLKQTNILSTRNTALGYSPCSFNLVNWVAIVSQPESVFLSPATKLAKIITGTVIAIGVFVILLTLPLAHWAVQPIVRLQKATELITEGRGLRPSTPRTISRASSFKRGFSSGFAVPSSLLQFNTAEAGSTTSVSGHGGSGHGSGAAFSANSSMKSAINLGNEKMSPPEEENKIPNNHTDAKISMDGSLNHDLLGPHSLRHNDTDRSSNRSHILTTSANLTEARLPDYRRLFSDELSDLTETFNTMTDALDQHYALLEERVRARTKQLEAAKIEAEAANEAKTVFIANISHELRTPLNGILGMTAISMEETDVNKIRNSLKLIFRSGELLLHILTELLTFSKNVLQRTKLEKRDFCITDVALQIKSIFGKVAKDQRVRLSISLFPNLIRTMVLWGDSNRIIQIVMNLVSNALKFTPVDGTVDVRMKLLGEYDKELSEKKQYKEVYIKKGTEVTENLETTDKYDLPTLSNHRKSVDLESSATSLGSNRDTSTIQEEITKRNTVANESIYKKVNDREKASNDDVSSIVSTTTSSYDNAIFNSQFNKAPGSDDEEGGNLGRPIENPKTWVISIEVEDTGPGIDPSLQESVFHPFVQGDQTLSRQYGGTGLGLSICRQLANMMHGTMKLESKVGVGSKFTFTLPLNQTKEISFADMEFPFEDEFNPESRKNRRVKFSVAKSIKSRQSTSSVATPATNRSSLTNDVLPEVRSKGKHETKDVGNPNMGREEKNDNGGLEQLQEKNIKPSICLTGAEVNEQNSLSSKHRSRHEGLGSVNLDRPFLQSTGTATSSRNIPTVKDDDKNETSVKILVVEDNHVNQEVIKRMLNLEGIENIELACDGQEAFDKVKELTSKGENYNMIFMDVQMPKVDGLLSTKMIRRDLGYTSPIVALTAFADDSNIKECLESGMNGFLSKPIKRPKLKTILTEFCAAYQGKKNNK
Protein: Large ribosomal subunit protein uL1m (54S ribosomal protein L1, mitochondrial) (Q04599)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL4m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein uS2m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein uL13m
Sequence:
MLSVVAIPKICVTGPARRCFFHTAKKLYADDYKPAAMSSNAPSLTKDQAKKRELKRLVQRKAEAKRPATASPLYMPVTKALRYLRAAEVGRPQSQQTINLTTLVVGERGTAPLSGSVTFPKPLRYIKIAAFTNDESKLEELREKYPNHLIGGADLVAKIKSGEISVDFDKAFATPDIVPALQSQVARILGPRGVLPSVKKGTVSDDISSLLQESLGSMPFRQRGNSISIGVGKCYFTDREILQNIISARAAFKTAVDNQKSKKPNILSKTTLSSTHGPGIVIDFA
Protein: Sulfate transporter (Diastrophic dysplasia protein homolog) (ST-OB) (Solute carrier family 26 member 2) (Q62273)
Organism: Mus musculus (Mouse)
Function: Sulfate transporter. May play a role in endochondral bone formation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P50443}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O70531}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 13 member 1
- Matrilin-3
- Solute carrier family 13
Sequence:
MSSENKEQHDLSPRDLPEEAFGFPSELPLETQRRSGTDLRQSETGHGRRAFRRIHMELREKPDTDIKQFVIRELQKSCQCSAAKVRDGAFDFFPVLRWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPIYGLYTSFFASIIYFLFGTSRHISVGIFGILCLMIGEVVDRELHKACPDTDATSSSIAVFSSGCVVVNHTLDGLCDKSCYAIKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLSLPRSHGVGSVITTWIHIFRNIRNTNICDLITSLLCLLVLVPSKELNEHFKDKLKAPIPVELIVVVAATLASHFGKLNGNYNSSIAGHIPTGFMPPKAPDWSLIPNVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCITTSAALAKTLVKESTGCQTQLSAIVTALVLLLVLLVIAPLFYSLQKCVLGVITIVNLRGALLKFRDLPKMWRLSRMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQKPKNSLLGLEEESETFESISTYKNLRSKSGIKVFRFIAPLYYINKECFKSALYKKALNPVLVKAAWKKAAKRKLKEEMVTFRGDPDEVSMQLSHDPLEVHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAVGIQVLLAQCNPSVRDSLARGEYCKKEEETLLFYSLSEAVAFAEDSQNQKGVCVVNGLSLSGD
Protein: Set1 complex component shg1 (Set1C component shg1) (COMPASS component shg1) (Complex proteins associated with set1 protein shg1) (Q10321)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The Set1 complex specifically methylates 'Lys-4' of histone H3.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Set1 complex component swd3
- Set1 complex component swd2
- Set1 complex component swd1
- Set1 complex component ash2
- Set1 complex component spp1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Set1 complex component sdc1
- RNA polymerase II holoenzyme cyclin-like subunit
- Serine/threonine-protein kinase srb10
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MDRDVTLNVDELVSKFKKEGHFDRLRKQILETVNEKESGPLLDRLKKIIDEEMVKDRTLKSKDQFRAAPLIAGAVDRSSLYEDSMEHIRSNVLSDQDLREVIYNSLEQIGIEQIEHEDEEKLLNSKTMDGRK
Protein: ATP-dependent DNA helicase-like PIF8 (DNA repair and recombination protein PIF8) (Q57VU6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for cell viability. Has probably no helicase activity, missing at least two of seven conserved helicase motifs.
Subcellular location: Mitochondrion matrix, kinetoplast {ECO:0000269|PubMed:19646907, ECO:0000269|PubMed:22220754}. Note=Localizes primarily to the distal face of the kDNA disk. Localization varies with different kDNA replication stages.
Interaction partners:
- Mitochondrial DNA polymerase beta-PAK
Sequence:
MTRCRLVGASSGGKYISTTNAKTRPVMGCLRFASRLSALGSTQQPKFFALPLLATTRGFGHLVREVDMRGFRGDFGQLRHKNLASTQRYVTDALGAKKNVIFCGAYHTGKLTILKAIGEACEARGKKVAYVSCNPQRASRFGGFLLYHFVGLRYLFRNEIPSRDQLDGALERHARLCESTYAGCVPSLKSVDVLIFDAVDQLEPTILASMDAVCRRLRGKPNDAFGGLRVFAAADFWRLPVHPSSDTGGYIFQLDNWGELFPKQHLLKKIYGQTKALTTLVNKAYYGQLSAEDIEELEARSSAGRTESGAACGGSKKEASETSGSFSVSDDGSRQVEVEEEGAGSGLLPPQRLISNAEAIIKFTSRFPKQPSIRVLPPRFRTLKRTEIGNYIVNMMVQSSTLHSFGLVDSLNLDIGASVHLLFDGTADFGVTAGTVGEVLQVKEHALVVHFPSVHRTVDVPRMRISVYHPFYPEVRYEVQQFPLYPRHCISPINMLTYHHAYQVHIDCHQLADTNDLGNILARMRTFDDFTIERVHDFAHLDGMVHEPTRIYYQRIDNQPLSSAAEQWCRNCKSYVSTSDFYTHWDKCVRQVRWCTVCNTRIPLERLGPHQEKHQIVLCLDCGRAVEWRRWEGHRLTCSAMMREVSPENEFLPLRTRQLALEMGLDKRDLHTMKGFNRGMLPKSRKQCNGGEA
Protein: Carboxylesterase NlhH (EC 3.1.1.1) (NLH-H) (P9WK87)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Hydrolyzes various short-chain esters, such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates.
Interaction partners:
- Esterase LipI
- Triacylglycerol lipase
- Putative hydrolase LipZ
- Phospholipase Culp4
Sequence:
MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPPELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLAPGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA
Protein: Stress-responsive protein 1 (O94629)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Stress-responsive protein that may play a role in regulation of cell cycle.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18410345}.
Interaction partners:
- Uncharacterized HTH La-type RNA-binding protein C1527.03
Sequence:
MFSILKQGVISKSLLAATSLKATASRFSFSTSVASRVDGTKNGWSFTASNVADQTTDIGINSESAMSCNDQEQPLSFYVQTVRDDLNSPNWGAEQRKGAFDWEVSA
Protein: IQ motif and Sec7 domain ArfGEF 2 (A0A8I6GKX8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWSQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
Protein: SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) (Q9BQ15)
Organism: Homo sapiens (Human)
Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Subcellular location: Nucleus {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
Interaction partners:
- SOSS complex subunit C
- Integrator complex subunit 3
- Integrator complex subunit 6
- Integrator complex subunit 1
- Integrator complex subunit 5
- SOSS complex subunit B2
- Integrator complex subunit 9
- Serine-protein kinase ATM
- Integrator complex subunit 11
- Single-stranded DNA-binding protein, mitochondrial
Sequence:
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYSTQQAPNKAVQNDSNPSASQPTTGPSAASPASENQNGNGLSAPPGPGGGPHPPHTPSHPPSTRITRSQPNHTPAGPPGPSSNPVSNGKETRRSSKR
Protein: ABC transporter B family member 6 (ABC transporter ABCB.6) (AtABCB6) (Multidrug resistance protein 6) (P-glycoprotein 6) (Q8LPT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g03540
- Cytochrome b561 and DOMON domain-containing protein At4g12980
Sequence:
MMISRGLFGWSPPHIQPLTPVSEVSEPPESPSPYLDPGAEHGGTGTAAQADDEEEMEEPEEMEPPPAAVPFSQLFACADRFDWVLMVFGSVAAAAHGTALIVYLHYFAKIVQVLAFPTDSDHLISDDQFNRLLELSLTIVYIAGGVFISGWIEVSCWILTGERQTAVIRSKYVQVLLNQDMSFFDTYGNNGDIVSQVLSDVLLIQSALSEKVGNYIHNMATFISGLIIGFVNCWEIALITLATGPFIVAAGGISNIFLHRLAENIQDAYAEAASIAEQAVSYVRTLYAFTNETLAKYSYATSLQATLRYGILISLVQGLGLGFTYGLAICSCAMQLWIGRFFVIHHRANGGEIITALFAVILSGLGLNQAATNFYSFDQGRIAAYRLFEMISRSSSGTNQEGIILSAVQGNIEFRNVYFSYLSRPEIPILSGFYLTVPAKKAVALVGRNGSGKSSIIPLMERFYDPTLGEVLLDGENIKNLKLEWLRSQIGLVTQEPALLSLSIRENIAYGRDATLDQIEEAAKKAHAHTFISSLEKGYETQVGKTGLTLTEEQKIKLSIARAVLLDPTILLLDEVTGGLDFEAERVVQEALDLLMLGRSTIIIARRLSLIRNADYIAVMEEGQLLEMGTHDELINLGNLYAELLKCEEATKLPRRMPVRNYNDSAAFQAERDSSAGRGFQEPSSPKMAKSPSLQRGHNVFRSQELCFNSEESPNDHSPAPEKLGENGSSLDVGEKEPTIKRQDSFEMRLPELPKIDIQCPQRQKSNGSDPESPISPLLISDPQNERSHSQTFSRPLGHSDDTSASVKVAKDGQHKEPPSFWRLAQLSFPEWLYAVLGSIGAAIFGSFNPLLAYVIALVVTTYYTSKGSHLREEVDKWCLIIACMGIVTVVANFLQHFYFGIMGEKMTERVRRMMFSAMLRNEVGWYDEEENSPDTLSMRLANDATFVRAAFSNRLSIFIQDSFAVIVAILIGLLLGWRLALVALATLPVLTLSAIAQKLWLAGFSKGIQEMHRKASLVLEDAVRNIYTVVAFCAGNKVMELYRLQLQRILRQSFFHGMAIGFAFGFSQFLLFACNALLLWYTALSVDRRYMKLSTALTEYMVFSFATFALVEPFGLAPYILKRRRSLASVFEIIDRVPTIEPDDTSALSPPNVYGSIELKNIDFCYPTRPEVLVLSNFSLKVNGGQTVAVVGVSGSGKSTIISLIERYYDPVAGQVLLDGRDLKSYNLRWLRSHMGLIQQEPIIFSTTIRENIIYARHNASEAEMKEAARIANAHHFISSLPHGYDTHIGMRGVELTQGQKQRIAIARVVLKNAPILLIDEASSSIESESSRVVQEALDTLIMGNKTTILIAHRVAMMRHVDNIVVLNGGKIVEEGTHDCLAGKNGLYVRLMQPHFGKNLRRHQLI
Protein: AT07210p (Toucan, isoform C) (Q8IPZ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLRRFIRKHFGSKNSLGSAVKIIKSIENDELKNKRLNGTLASTAAIATPIKGVATKSGATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKELDAVACKENKHQCARTKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLKFCELESQLRAKDEESKQAQEAYRMEVSHKLALKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVLELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVMKGMIERNDSVSWTLEIEDESFKGNTSKIVRRAGSLRSNNERCPIQRRQTLTSNGHSNGSATNGGSSPAHPNPLSQSMSATALLRSSSNSGESEGRPLSRARSKSMCIKASATSSAVCESSGQRKKPQDELSLADWPEDIPLCSSSPQAPGIEMRPRSSTMKLMSSEAKKFQEIQESAGEAMVSGANSEDESCSASSEDIMRSSSASSTASGGSLSKRPKQPPSRMSIEEALPCTPMEVSWSEDAADANGLA
Protein: Collagen alpha-1(X) chain (P23206)
Organism: Bos taurus (Bovine)
Function: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- SRY-box transcription factor 9
- Collagenase 3
- Runt-related transcription factor
- Hedgehog protein
- Cartilage oligomeric matrix protein
- Alkaline phosphatase, tissue-nonspecific isozyme
- VWFA domain-containing protein.
- Osteocalcin
Sequence:
MLPQTALLLLMSLNLVHGVFYTERYQTPTGIKGPPSNTKTQFFIPYAIKGKGVSLRGEQGIPGPPGPAGPRGHPGPSGPPGKPGTGSPGPQGQPGLPGPPGPSATGKPGLPGLPGKQGERGLNGPKGDIGPAGLPGPRGPPGPPGIPGPAGISVPGKPGPQGPTGEPGPRGFPGEKGTSGVPGLNGQKGEMGHCTPCRPGERGLPGPQGPTGPPGPPGVGKRGENGLPGQPGLKGDQGVPGERGAAGPSGPQGPPGEQGPEGIGKPGAPGIPGQPGIPGMKGQPGAPGTAGLPGAPGFGKPGLPGLKGQRGPVGLPGSPGAKGEQGPAGHPGEAGLPGPSGNMGPQGPKGIPGNPGLPGPKGEMGPVGPAGNPGAKGERGSSGLDGKPGYPGEPGLNGPKGNPGLPGPKGDPGIAGSPGLPGPVGPAGAKGVPGHNGEAGPRGVPGIPGTRGPIGPPGIPGFPGSKGDVGTPGPPGPAGIAVKGLNGPTGPPGPPGPRGNAGEPGLPGPPGPPGPPGQVALPEDFVKAGQRPFVSANQGVTGMPVSAFTVILSKAYPAIGTPIPFDKILYNKQQHYDPRTGIFTCKIPGIYYFSYHIHVKGTHAWVGLYKNGTPVMYTYDEYIKGYLDQASGSAVIDLTENDQVWLQLPNAGSNGLYSPEYVHSSFSGFLVAPM