wanglab/gogpt-training-data huggingface dataset:
Protein: Tropomyosin 1 (Tropomyosin 1 isoform 2) (A0A0S2Z4G6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM
Protein: At5g10040 (Transmembrane protein) (Q9LX24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At4g39675
- CBL-interacting Serine/Threonine-kinase
- Protein S40-4
- Ceramide synthase 1 LOH3
- Ceramide synthase LOH1
- LOB domain-containing protein 41
- Alpha/beta-Hydrolases superfamily protein
- Delta-9 acyl-lipid desaturase 2
Sequence:
MDSSADIAILVADECNQKVNTTAEKASNTAEVGWLMMFGIEEKKIESLMRKFEAKSQFAVAVSSGFFLLNYVSSLYYKSRLNLMLEI
Protein: Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) (Q99M80)
Organism: Mus musculus (Mouse)
Function: May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MGSLGGLALCLLRLLLLGLQRPPLPGAGAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGAPMGSAQVTPGTPLCLLTTASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQREMGPVASTDKPTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
Protein: Nucleic acid-binding, OB-fold-like protein (F4IMC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized mitochondrial protein AtMg00370
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein uL5c
- ATP synthase subunit alpha
- 50S ribosomal protein L33
- Large ribosomal subunit protein uL24c
- At1g43860
- Large ribosomal subunit protein bL28c
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Large ribosomal subunit protein eL42z/eL42y
Sequence:
MRPGRARALRQFTLSTGKSAGRNSSGRITVFHRGGGSKRLLRRIDLKRSTSSMGIVESIEYDPNRSSQIAPVRWIKGGCQKKMNTIEKFAPPRKILEPTTNTISGLFSFSFLPGKVDKRKVACFSPGLMAAYVVVGLPTGMPPLSSSKSAFASKGAGSTKTLVKDVFFSAFSSLKAKRETASLAFASSFGFPRIAVAGAKPAFFAPRMRQKVRGKSTFSLCEVQKGRTHSILWAHRIKGKAGLSWQSFRRQDTLGLVGAAGHKKSKPKTDQGNLPAKPIGERAKQLKALRGLRAKDGACKVDLTREERSNGKAIRPFGSSRSIAHIQISYLIGERGNTHEAPTEREGLPGRMPMGAGFFEKARADSETWDLGLATNEYFSSSFLRQRLM
Protein: Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) (Q9JLN4)
Organism: Rattus norvegicus (Rat)
Function: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor.
Subcellular location: Secreted {ECO:0000250}. Cytoplasmic granule {ECO:0000250}.
Interaction partners:
- Triggering receptor expressed on myeloid cells 1
- Cathelicidin antimicrobial peptide
Sequence:
MLFAWAPFPALLGLADSCCFVVPRSEWKALPSECSKGLKKPVRYVVISHTAGSFCSSPDSCEQQARNVQLYQMKQLGWCDVAYNFLIGEDGHVYEGRGWTIKGDHTGPIWNPMSIGITFMGDYSHRVPAKRALRAALNLLKCGVSEGFLRSNYEVKGHRDVQSTLSPGDQLYEIIQSWDHYRE
Protein: Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (Activin receptor-like kinase 6) (ALK-6) (Serine/threonine-protein kinase receptor R6) (SKR6) (CD antigen CDw293) (P36898)
Organism: Mus musculus (Mouse)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14523231, ECO:0000269|PubMed:24129431, ECO:0000269|PubMed:26105076}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Bone morphogenetic protein 6
- Bone morphogenetic protein 7
- Bone morphogenetic protein 4
- Growth/differentiation factor 5
- Activin receptor type-1
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein 2
- Activin receptor type-2B
- Bone morphogenetic protein 15
Sequence:
MLLRSSGKLNVGTKKEDGESTAPTPRPKILRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGMPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSESQDIKL
Protein: Protein TALPID3 (H6D7E6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22028029}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22028029}.
Interaction partners:
- Centrosomal protein 120.
- Centrosomal protein 97.
- Centrosomal protein of 290 kDa
- C2 domain-containing 3 centriole elongation regulator.
- Centriole and centriolar satellite protein ofd1
- Intraflagellar transport 88 homolog.
Sequence:
MDSCCVSVNNKTHFNDSTSSSDAADVLIHSTRAGRDEIQDKSQNKVNIYIRRLSDSEHVHSADERRTEIPPVNLPTASDTAGPEEPLAGIKSNQFAGLFGKTSRKEKSKAQSTIMQTEQLKSKGEDVQISTFSADGRGVVSAALRKRSQGAPIRRNVTVQVLDQDRSQTPAGVQPDPAFPLGDPGTSASVAAITAATLAATAPLMKAQSEMEAQISRVSAELKRLQAAEGSVPPGRTARTDSSSAGRAAHLEEQLNILIQQRLQHLETIQCQQIQLQNRLLGSALDVVASRGNSSGVSQTDSLPLQISGNRSIRLSATDNPSAGRPASVSMDVYRERQTGGHKSPLETPAPRKVIPKPTHWTSSTSTNRPPKSSFKNQGNGRLQDQSPNNRRSPERCALQSVGVERFAMATADNSQPEQSRESQMPSKASVTRSAQEDGSSFVNGQNEQERQGEPTNVSSSSTTVQKASEMLQDLGRLKNEMRSLLQTADAFPVPNAKSTQSSRSRHLAPVATAPPPATAPISMPPEPVDVIAVRAAALNRASVLKSIQPPTSMFEDAGLVLRQVRQSKKTLEENLEAILRAKDGEVLHTQLEALSKNRDVREELRIKKTVDAWINTLSKEIQDDLARESSERIVDAAVSRREAGQRTRAEASAAAKKTSVRAQAGNTRAHTRQPAPAVRNKPAVKQEATQPIVLKSQDDEEYLARLYGKAIYDGQRRTLKKSPYLRFNSPTPKSKPQRPKIVETVKGVKMKSSKTQTSQYVGDVSAMQHSVSEPHFIFSPSDPDKQQQQPGSPVRGYLIPMAIPLGKPRVDCQPPVPSRVIITDKPAIVTTSFPPITVVESKPTPAIRKPNAILLEVQSAPKKRTPQLQIQVQPGVNIESALCSSRQASPTPVIPAESILPPPSIHATEDPHAHEDQQENIFPGTNFLAQADISQETNGGLPDSPIEFKGLPSPPADLYHGPVFPPVPTQSTPLTEPILNTIQQRETLENRLVDWVEQQIMARVITGMFPQPAQADPVHQSEPENSVASDIVEAAGGSGLQLFVDTGVPVDSEVIRHYVNEVLTEIIASMLGQREAQGTPATLVQTQDAQKEDTTVPTPAPTPEPSLKDPPSPVRTPDLSEHLSTATSPEKPPQESASPGPDRIPVGTPITTPIPSPTRVATPSPPTPANQSPEPGSLQIHLWEGSELPLEEEEQPELQPAPVVISVPRVDDQEESVIHPSSPVLSKPQSPPAPPLPPVIQKSESSSSSSSSSSESSCSSSVTVTETETAARHISEGELLLNHGQMAAVRVLEQEGVLLPNFMTSLNGSLHGVQDMDYDPPSEGQVIRAPHLPAHHDPVLSLLARMELGPISQSQQPEGWWEEESSGEVSEGQRPVLTAAEEIVLTGHSLMDQQTIRQSRNTQISPHATLTSPGQVIAEHTGAVVEDGGLSVNLRSSDEQKEAMVYQADTVSSPQPESSQMAQTVHRPAPILVRQYEEEPDFPQLRRLSDDAFFGADEKGEDTFLHTGEGGGGGRGSDVRVMSVRLPSVKQDQESVSLSSVEGDTDSSANDVF
Protein: Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2) (Q4V9F0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96PD7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PD7}. Lipid droplet {ECO:0000250|UniProtKB:Q96PD7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PD7}.
Interaction partners:
- O-acyltransferase
- O-acyltransferase.
- Phospholipid phosphatase 5.
- Acyltransferase
- Monoacylglycerol O-acyltransferase 3a.
- Acyltransferase
- acidPPc domain-containing protein.
- Phosphatidic acid phosphatase type 2D
- Phospholipid phosphatase 2
- Phospholipid phosphatase 2b.
Sequence:
MKTILAAYSGVKKGSGSSILSALHDLPTVPWLTRSKMVKHLQVISVLQFIMTFLTMGIACSLLLMYMFCTDFWVISVLYVAWLIYDWNTPGQGGRRSTWVRDWTVWKYMRDYFPIRLIKTHNLLPSRNYIFGYHPHGILCFGAFCNFGTEATGFTKVFPGIKPSLATLAGNFRLPMFREYLMCGGICPVNRNSIDYLLSSNGTGNAVVIVIGGAAESLDCAPGRNSVMLKKRKGFVKLALKQGADLVPVYSFGENEVYKQLIFEEGSWWRTIQRKLQKFLGFAPCLFHGCGLFFPESWGLVPYCKPITTVVGEPITVPKIEEPTQDVIDMYHAMYIRSLKSLFDNYKTRFGLNESDTLIIH
Protein: Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74) (Q8TCD6)
Organism: Homo sapiens (Human)
Function: Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
Interaction partners:
- Pyridoxine-5'-phosphate oxidase
- Pyridoxal kinase
- Aldehyde oxidase
- Chronophin
Sequence:
MKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFWTEFMGRVFKYLGDKGVREHEMKRAVTSLPFTPGMVELFNFIRKNKDKFDCIIISDSNSVFIDWVLEAASFHDIFDKVFTNPAAFNSNGHLTVENYHTHSCNRCPKNLCKKVVLIEFVDKQLQQGVNYTQIVYIGDGGNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPMEYSVVVWSSGVDIISHLQFLIKD
Protein: MAGE protein (Q001T8)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Non-structural maintenance of chromosomes element 4
- Non-structural maintenance of chromosomes element 1 homolog
- SP-RING-type domain-containing protein.
- Structural maintenance of chromosomes protein 6
- Structural maintenance of chromosomes protein 5
- Structural maintenance of chromosomes protein
- Tripartite motif containing 28.
- Neurexophilin
Sequence:
MSQRKRSRGSGLTQGDDEDFSVVPTQSPSQVQRNLESRSQEEINRKVTELVQFLLVKDQKKIPIKRVDILKKVIREYKDVYSEIVNRAGRTLQQVFGLQMVEIDTKHHIYILTSTLPRVEGENLKQDIQTAKLGLLIVILSFIFMKGNSAKDSAVWEFLRRLRVHPGEKHEVFGDVKKLVMEEFVRQKYLEITPIPLTDPPEFNFQWGPRAAKETSKKDILSFVAKMQKKEPSFWISQYNEAKANT
Protein: Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein) (Q9Y6I8)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein 2
- Peroxisomal membrane protein PMP34
- Peroxisomal membrane protein PEX16
- ATP-binding cassette sub-family D member 3
- Peroxisomal membrane protein PEX13
- ATP-binding cassette sub-family D member 1
- ATP-binding cassette sub-family D member 2
Sequence:
MAAPPQLRALLVVVNALLRKRRYHAALAVLKGFRNGAVYGAKIRAPHALVMTFLFRNGSLQEKLWAILQATYIHSWNLARFVFTYKGLRALQSYIQGKTYPAHAFLAAFLGGILVFGENNNINSQINMYLLSRVLFALSRLAVEKGYIPEPRWDPFPLLTAVVWGLVLWLFEYHRSTLQPSLQSSMTYLYEDSNVWHDISDFLVYNKSRPSN
Protein: Cocosin 1 (11S globulin 1) (CnCOS-1) [Cleaved into: Cocosin 1 acidic chain; Cocosin 1 basic chain] (A0A222NNM9)
Organism: Cocos nucifera (Coconut palm)
Function: Seed storage protein.
Interaction partners:
Sequence:
MGSSSLLSFSLCLLLLCHLSQAQFGSSQESPFQSPRRSVSSRNECRIERLNALEPTRTVRSEAGVTDYFDEDNEQFRCAGVSTIRRVIEPRGLLLPSMSNAPRLVYIVQGRGIVGLVMPGCPETFQSFQRSEREEGERHRWSRDEHQKVYQFQEGDVLAVPNGFAYWCYNNGENPVVAITVLDTSNDANQLDRSHRQFLLAGRQEQGRQRYGREGSIKENILRGFSTELLAAAFGVNMELARKLQCRDDTRGEIVRAENGLQVLRPSGMEEEEREEGRSINGFEETYCSMKIKQNIGDPRRADVFNPRGGRITTLNSEKLPILRFIQMSAERVVLYRNAMVSPHWNINAHSIMYCTGGRGRVEVADDRGETVFDGELRQGQLLIVPQNFAMLERAGSEGFQLVSIKTSDRAMVSTIVGKTSALRGMPVEVLMNSYRLSRDEARRVKLTRGDEVAIFTPRRESRAEA
Protein: Protein rot1 (O14103)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Protein big1
- Uncharacterized protein C11C11.05
- Probable very-long-chain
Sequence:
MHLLYQIGLFTCLWLTQYVGAEIDNYDENLVGTWSSKSETVLTGPDFFDPLDEDFFEPELPGISYSFTDDGFFEEAIYIIKSNATKPQCPKGFLQWQHGTYAINDTGTLVLTPFVGDGRQLESDPCTSNFSVYTRYDQVETMEKYEISMDRYHGRYKLELYEWDGTPKQPMFLAYRPPKMLPTSTIAVNTIQTAAKRWTAPLVPLAQKHTNTIWWVGLGLIAIGSIGYLVVS
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (O06830)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Long-chain-fatty-acid--CoA ligase FadD13
- Probable esterase LipO
Sequence:
MSETDSPGNGDDAGIGDIGKFDPGLTQRLISVLRPVLKTYHRSQVHGLDSFPPGGALVVANHSGGMFPMDVPVFSVDFYDKFGYDRPVYTLSHDILFMGLTGDLFRRTGYIRATRENAAKALRSGGVVVVFPGGDYDAYRPTFAENVIDFNGRKGYVSTAVEAGVPIVPAVSIGGQESQLYLSRGTWLARRLGLKRLLRSDILPISFGFPFGFSAAIPPNLPLPAKIVMQVLDPINLTKQFGEDPDVDAVDEHVRSVMQQALNDLAAKRRFPILG
Protein: Doublesex- and mab-3-related transcription factor dmd-5 (Q19291)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Required for sex-specific synaptic pruning, probably acting downstream of sex-determining transformer protein tra-1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- DM domain-containing protein.
- DM domain-containing protein mab-23
Sequence:
MPVSPSSVSVLPPTSLEQILRIRAERNQRTPKCARCRNHGTTSALKGHKRYCQWKDCMCAKCTLIAERQRVMAAQVALRRQQSQEERDARDLEVLLGSAGNANDLLDILRLDAGEHHGKNHASPTTNNNNNTEEKYEDSQGQRSSPSSPTGSETVVSTSSPPELSSESTPNTSGSVIPTSPVFKPNGYSSMPMFNPVYGRPFMRFPMFSVMPHFFGTPSMSDFASAASLAAPPAFFSAQPTIATSSPSTIFPQTAPLDYSHRLMKNEEAEEEYRENDKTF
Protein: HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) (Q6AI08)
Organism: Homo sapiens (Human)
Function: Amplification-dependent oncogene.
Interaction partners:
- Nuclear receptor coactivator 3
- Estrogen receptor
Sequence:
MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ
Protein: Transcriptional adapter (D3Z4Z0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR025024}.
Interaction partners:
- Transcriptional adapter 3
- Transformation/transcription domain-associated protein
- SPT3, SAGA and STAGA complex component
- SAGA-associated factor 29
- Transcription initiation factor TFIID subunit 12
- Histone acetyltransferase KAT2A
- Transcription initiation factor TFIID subunit 10
- Transcriptional adapter 1
- STAGA complex 65 subunit gamma
- TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Sequence:
MAELGKKYCVYCLAEVSPLRFRCTECQDIELCPECFSAGAEIGHHRRYHGYQLVDGGRFTLWGPEAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKTLKRKITKEEKELRLKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYEAARHKRERRKENKNLASSKRGKEDGKDSEFAAIENLPGFELLSDREKVLCSSLNLSPARYVTVKTIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLTESGWISRDAS
Protein: Neuronal PAS domain-containing protein 4A (Neuronal PAS4A) (Q1ECW2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8BGD7, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator 2
- Aryl hydrocarbon receptor nuclear translocator-like 1a
- Protein c-Fos
- Nuclear receptor subfamily 4, group A, member 1.
- Mage
- Early growth response protein 1
- Aryl hydrocarbon receptor nuclear translocator.
- Brain-derived neurotrophic factor
- Early growth response 4
Sequence:
MYRSTKGASKARRDQINAEIRNLKDLLPISDADKSRLSYLHIMSLACMYTRKSVFFSQDITTASSAEETTGFLSFYELNELIQGMPGFLLLLTGEGKLLYLSDSVSDHLGHSMVDLVAQGDSVYDIIDTADHFIMRSNLVPPTSPDTDRLFRCRFNTSKSVRRQSAGNKLVLIRARCLSQTPSESSPGSYWTSNPVWVCFCAPLEPHTSRGGTASDRESTSASALESSFFLPCFRSQHSRDMRLHEAQESVSVYLGLNVEILRSQSWYSFLHPQDLSHASAQHCSLLREGGEGRAEMVVRVETADHSWVWLYMVLQLETGETPIVSNNYIISETEAWSVRQQLSSEQTQLSLVLGSSTSQQESVSLQSPETLSSPDQVFTPGSSGLSGQSFDFSTAACSTGSTEEQGGSSSMEPAQVESGPRSSLSSMEEETFFQHEPSEPMASPSSASSPIPVTVATVSDLDFLTQNILLPPAFQIDPPLPVLPLPLPPVPTSQAQQTKEFVCTPPYTPQLGGSNFPFGEPHFSFDPTGATSPPPLGQTATVTTTTAPSLSPSAPSNPQSSPPPPTTTLSSLLPLTITSPTTEILFPVEPCSGSLYEKLPPTPDSPGDGDCTVMTLPEVRGPLYVDVPHGPLPYPPEGLLTPEASPGKQPSLPFFSSLRDREKERTEISLLAQHISTLAEGFYLDPLLAKLVPSTLSEHSQSPDSDGLDSIPLLGEFYPLKSWKGLDLPIFQDDESLFEESVLETLLQDLSSSPPLSPTPSSSSHSSPPSSPSTPECWCPSLHFDGVSAVSAGHFCSVQSAHCNNEAGRGAMMSPVNAGNMTDTKAAGEVPMETDVASSPLFTGIPTSPPLQLTASPASPILMPVSSPVSPPSPGLPCAQSLLEELAALEPMFGAGASIAPGLGQQPELYQLQSHVPQQCFRKDGSGSDPPF
Protein: Fe-S cluster assembly protein dre2 (Anamorsin homolog) (O74821)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit suc22.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16823372}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115}.
Interaction partners:
- NADPH-dependent diflavin oxidoreductase 1
- Cytosolic Fe-S cluster assembly factor nbp35
- Cytosolic Fe-S cluster assembly factor NAR1 homolog
- Monothiol glutaredoxin-4
- Monothiol glutaredoxin-5
- DNA repair/transcription protein mms19
- MIP18 family protein C144.16
- Probable cysteine desulfurase, mitochondrial
- Iron-sulfur clusters transporter atm1, mitochondrial
- Translation initiation factor rli1
Sequence:
MSSSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQSQLVNLPINRYDSVIAAIDDGAWSSTLGPILSQAFASVHPGGTLRVYSTADEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKLSNKNGQSASKNKILDFLKSDKENLISGDDDQELIDEDELLDESAHDNVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSAQLEAVKLTDTTEVDFTEKLKSKNAVSSCGNCYLGDAFRCSGCPYIGMPAFNPGDTVILAENRDKMSWMADDI
Protein: F-box domain-containing protein (Q9TZ26)
Organism: Caenorhabditis elegans
Interaction partners:
- Uncharacterized protein T25D10.1
- CUB_2 domain-containing protein
- CUB_2 domain-containing protein
- ShKT domain-containing protein
- CUB-like domain-containing protein
- Cytochrome b561 domain-containing protein
- C-type lectin domain-containing protein
- C-type lectin domain-containing protein
- SNF2 N-terminal domain-containing protein
- Cysteine-rich protein 1
Sequence:
MTDITVGITVGIIVGIWLVGKLPWHCLGATIPIRHKGSSRDIAPKTHQKNLVLPTFLNMPLNIANLVLEKMELKDLLKARKVCRSLRTAVDKFGLRFDQINLFLGRDNVEICMRGTTIRYTTAANGNSNVTHNGQKTIIAEENFVERAAKDFKILSKHARKIDIRNFTENRRDIIKTFNEIWNTEKCILVKEIRLRHFSFDEVLTNLPWFNAKKLKTIELNWMKSIDRFERITQLEQWKNAEVVKIGSKIASIMIVHFFHFKCFTINHIDEFPAQAAIQMRDDLLRRSTFQSCYIIFYKSKTNPIEIAKVFKPDYTGENVFNIEYSNGNDKFDISLQEFSYYFLLNMNRSLSV
Protein: Golgi-associated RAB2 interactor protein 1A (B2RXB0)
Organism: Mus musculus (Mouse)
Function: RAB2B effector protein required for accurate acrosome formation and normal male fertility.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:18256213}.
Interaction partners:
- Ras-related protein Rab-2B
Sequence:
MSKIRGLPPAIRDPGPGVELGVVDGLLCQLIHSPEFNLFSDSVVFESTFIQVTKQGNWMDAYERSATMILGVTSSVPSLPLPNILLMANVTWPHGPFSTCSTLGAPVITLSRILPLKYVELQIYDRTQRILRVRTVTEKIYYLRLHEKHPQAVFQFWIRLVKILQKGLSITTKDPRIQFTHCLVPKMSNSSTETATESSLPASSQNSEAIMLLAAERNSSSLLELSNRHQTSRDRHTDTATETDNSGNCKSTPLVASSASMPMRAALTHSLWEQEDSNENFLQAPVASSLGENLLGP