wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) (Q29408)
Organism: Ovis aries (Sheep)
Function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P22301}.
Interaction partners:
- Interleukin-10 receptor subunit alpha
- Interleukin-10 receptor subunit beta
- Interleukin-6
- T-cell surface glycoprotein CD4
- Interferon gamma
- Interleukin-4
- Interleukin-1 beta
- Interleukin-5
- Interleukin-2
- C-X-C motif chemokine
Sequence:
MPSSSAVLCCLVFLAGVAASRDASTLSDSSCTHFPASLPHMLRDVRAAFGKVKTFFQMKDQLNSMLLTQSLLDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKRVFNMLQERGVYKAMSEFDIFINYIESYMTTKM
Protein: Ring finger protein 111 (H0YKS2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLVVRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDND
Protein: Transmembrane protein 168 (Q9H0V1)
Organism: Homo sapiens (Human)
Function: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A. May play a role in the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (By similarity).
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:32175648}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MCKSLRYCFSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSNLWFGFLLGLLCFLDNSSFKNDVKEESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTVEFLELVGFAIASTTMLVEKSLSVILLVVALAMLIIDLRMKSFLAIPNLVIFAVLLFFSSLETPKNPIAFACFFICLITDPFLDIYFSGLSVTERWKPFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTHRTDYNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVGYAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGPRHDTYILYYSGHTHGTGEWALAGGDTLRLDTLIEWWREKNGSFCSRLIIVLDSENSTPWVKEVRKINDQYIAVQGAELIKTVDIEEADPPQLGDFTKDWVEYNCNSSNNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHLANWLCGLNLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLVKS
Protein: Pleurostatin (P84866)
Organism: Pleurotus ostreatus (Oyster mushroom) (White-rot fungus)
Function: Antifungal activity. Inhibits mycelial growth of F.oxysporum, M.oxysporum and P.piricola. Inhibits cell-free translation with an IC(50) of 28 uM. Antiproliferative activity against MBL2 and L1210 tumor cell lines in vitro.
Interaction partners:
Sequence:
VRPYLVAF
Protein: Adenosine receptor A3 (A3AR) (Q61618)
Organism: Mus musculus (Mouse)
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q28309}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Adenosine receptor A1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Kininogen-1
- HMW kininogen-II
- Transmembrane domain-containing protein TMIGD3
- Adenosine deaminase
- Ectonucleoside triphosphate diphosphohydrolase 1
- Adenosine receptor A2a
Sequence:
MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADIAVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVFFSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRAVRLCQTSDSLDSNMEQTTE
Protein: Transmembrane protein 186 (Q96B77)
Organism: Homo sapiens (Human)
Function: As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:32320651, ECO:0000305|PubMed:32275929}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
- Complex I assembly factor TMEM126B, mitochondrial
- Complex I intermediate-associated protein 30, mitochondrial
- NADH-ubiquinone oxidoreductase chain 3
- Complex I assembly factor ACAD9, mitochondrial
- Complex I assembly factor TIMMDC1, mitochondrial
- Cytochrome c oxidase assembly factor 1 homolog
- NADH dehydrogenase complex I, assembly factor 6
- NADH dehydrogenase 1 alpha subcomplex assembly factor 4
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
Sequence:
MAALLRAVRRFRGKAVWERPLHGLWCCSGQEDPKRWVGSSSPISKEKLPNAETEKFWMFYRFDAIRTFGFLSRLKLAQTALTVVALPPGYYLYSQGLLTLNTVCLMSGISGFALTMLCWMSYFLRRLVGILYLNESGTMLRVAHLNFWGWRQDTYCPMADVIPLTETKDRPQEMFVRIQRYSGKQTFYVTLRYGRILDRERFTQVFGVHQMLK
Protein: Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein) (Q80YD6)
Organism: Mus musculus (Mouse)
Function: Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Diphthamide biosynthesis protein 3
- Protein HEATR9
Sequence:
MARESCASETVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTGATEISCGSEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVCQLPAHPVPCQDLKVTCPLPDDTENTESQGAVDRDRLEGETISDLNPDRTRNGGGGCESETVQ
Protein: Reticulon-like protein (Q9VMW2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}.
Interaction partners:
Sequence:
MSNRLLESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTNEGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKKPEAAAESEKDK
Protein: Short-wave-sensitive opsin 1 (S opsin) (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP) (Short wavelength-sensitive cone opsin) (Q63652)
Organism: Rattus norvegicus (Rat)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P03999}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P51491}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P51491}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P03999}.
Interaction partners:
- Arrestin-C
- G protein subunit alpha transducin 2
- G protein subunit alpha transducin 1
- Medium-wave-sensitive opsin 1
- Guanine nucleotide-binding protein subunit gamma
- Cone-rod homeobox protein
- Recoverin
- Photoreceptor-specific nuclear receptor
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
Sequence:
MSGEDEFYLFQNISSVGPWDGPQYHIAPVWAFHLQAAFMGFVFFAGTPLNATVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYLVICKPFGNIRFNSKHALTVVLITWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEHYTWFLFIFCFIIPLSLICFSYFQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLYLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMTDESDMSGSQKTEVSTVSSSKVGPH
Protein: Selenide, water dikinase (EC 2.7.9.3) (Selenophosphate synthetase 2) (TbSPS2) (TbselD) (Q38A34)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Synthesizes selenophosphate from selenide and ATP.
Interaction partners:
- O-phosphoseryl-tRNA
- cysteine desulfurase
Sequence:
MSEKEGKVIPETNGMKRPRFDPVKLGLPEEFTLTDYTRLKGCSCKVPQPELLALLQSVSTTPGRRDVGMDCSIVKLQHKDETGKPLYMVSTTDFFFPSVEDPYLQGQIGAANVLSDLYSTGIDRCDTVLMLLAASTDMDKTEREVCTQEMMKGFVDHVRLAGSDVTGGQTVMNPWPLIGGIATSVVAESQMIRPTGLQPGDILVLTKPLGCQIAVNLKQWLRRPSPIFEEQIQGKMDSEEIEELYNAAADGMKRLNRMAAALMHSHGAHGATDVTGFGILGHAKNLGSAQKADVCLVLDSLPMYRGAVKASKLMGDKYRLFEGYAAETSGGLLVAFGTREEAEGYIRELYETDGEPAWVVGRVVRREGSAPYALLQKDYKIIEVGAKVNDKII
Protein: Erythrocyte membrane protein band 4.1-like 3 (A0A8I5ZVK0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MTTESGSDSESKPDQEAEPQEAAGPQEQAGAQAAPEPAGGNVEEQPGLEQFPEAAAHSTPVKREVSDKDRDFAAAAAKQLEYQQFEDDKLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGNDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDRRKKAEEATPVAALRHEGKTDSERTDTAADGETSATESDQEEDAELKAQELDKTQDELVKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTETIETEVEPTPHPQPLSTEKVLQETVLVEERHVMNVHASGDASHTARDDVDATESAPADRHSGNGKEGSSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVESISVGSVSPGGVKLETSTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQE
Protein: Spermatogenic leucine zipper protein 1 (BHLH-Zip transcription factor SPZ1) (Spermatogenic Zip 1) (Q99MY0)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15226296}. Nucleus {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:15226296}.
Interaction partners:
Sequence:
MSDTDNSAEMPARCPSPNPAPGAKQEPPNSGITISLLEIGSLPTVCYHSFPPPKNSICPVEKRGRVQKFSNLLKDVKDVLKNIAGVEEKSTVGEPFDDAYIPEDLSELNVRGVEKKNKIRFKDDLFIHFDPEREQNTMKQMLLKNQSAKNMVPKFARDLCNAEETRGFDGMLLSVKRPRNGSLHLRGEYRKLRNNMEQLLQEADHWSKQHNELSELMRSYQECQNETQETTDKDRACLQNQPNNGLSTKQKLEEQVKKLSHDTHALHLIAALLENECQVLQQRVDILKDFHLHEAGLGHEKPLQMSCEQDKKCPKLAEADKTDAFKHTTRATEGTIRKPKILRSPDVCFTKKARNNRFNARVAKKSLVGKRRTVSSFR
Protein: C-type lectin domain family 4, member b1 (Dendritic cell immuno-activating receptor beta isoform) (Q9D8Q7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVQERQLQGKAVSWSLRLWSAAVISILLLSTCFIASCVDKVWSCCPKDWKLFGSHCYLVPTVFSSASWNKSEENCSRMGAHLVVIHSQEEQDFITGILDIHAAYFIGLWDTGHRQWQWVDQTPYEESVTFWHNGEPSSDNEKCVTVYYRRNIGWGWNDISCNLKQKSVCQMKKINL
Protein: cAMP-dependent protein kinase type 1 (PKA 1) (EC 2.7.11.11) (CDC25-suppressing protein kinase) (PK-25) (P06244)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- cAMP-dependent protein kinase type 2
- cAMP-dependent protein kinase regulatory subunit
- Ras-like protein 2
- cAMP-dependent protein kinase type 3
- Adenylate cyclase
- Ras-like protein 1
- Autophagy-related protein 13
- Zinc finger protein MSN2
- Zinc finger protein MSN4
- Serine/threonine-protein kinase RIM15
Sequence:
MSTEEQNGGGQKSLDDRQGEESQKGETSERETTATESGNESKSVEKEGGETQEKPKQPHVTYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYGVQGEDPYADLFRDF
Protein: ceramide glucosyltransferase (EC 2.4.1.80) (Q9W297)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ceramide kinase, isoform A
- Putative neutral sphingomyelinase
- Sphingolipid delta
- LD18904p
- Neutral ceramidase
- Alkaline ceramidase
- Non-lysosomal glucosylceramidase
- Sphingomyelin phosphodiesterase
- Serine palmitoyltransferase 1
- Glucosylceramidase
Sequence:
MSHLPLPLYGFAAFFMVFWLGTWMVHVIAICYGRYKLHKKSCKLPTEAQPLPGVSILKPLMGVDPNLQHNLETFFTMDYPLYELLFCVEDKEDPAIQLVERLLAKYPLVDAALFVGGSDVGVNPKINNIHPGYMAAKYDFVMISDSGIKMKDDTLLDMVQNMSEKHALVHQMPFTCDRDGFAATFEKVFFGTVQSRIYLSADVLGINCHTGMSCLLRKAVIDQLGGLRAFGCYLAEDFFIARSVTRLGWKMRISNQPALQNSGLCDIGSFQARLIRWAKLRVAMVPTTILLEPLSECMILGAIAAWSASVLFSWDPLVFYLVHVLCWFLSDWLLLSIVQHGSMPFHKFEFVVGWLFRELTGPYLFLHALWNPAIRWRARTYKLHWGGVAYELNSLASDAANDPLAPQPQPAPTLEPAVVNAGTTGDTLICTGAKQRLLVS
Protein: Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial (Q05863)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL19m
- Putative uncharacterized protein YOL114C
Sequence:
MMRGASKRSISSAAVLLIKKNKLPPRPKFTPEMEAQCTEKFLHGGRGPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLARELAASYDTMPSREEALLQWHRQQKRSQRRRSVAKYEQREEAARVEKEEREARDREMVRELFRR
Protein: Carbohydrate sulfotransferase chst-1 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase) (Chondroitin 4-sulfotransferase) (C4S) (C4ST) (Q09272)
Organism: Caenorhabditis elegans
Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residue of chondroitin.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Chondroitin sulfate synthase mig-22
- Exostosin-like-3 homolog
- Obg-like ATPase 1
- UDP-glucose 6-dehydrogenase
Sequence:
MLKWFIISCCLLTAISYSTYYLFTSNSWIKTVKTHTYSRFYQLIKENTKTQLDRLQEEAKLSGKSLIPPFINFDREYAIAPKYNISICRIKKSMSTLMSGVACVLYDTGKFMRNNRSILEVWSHRFCGEKNEYRRMNEVKWRMGDAHHTFKKIVVIRDPIARFISFFSNKCIFEAQKYPDRKQCYNCQGNVTCFLEKQYERFVQHSSDYSRIRPSYEDKHAAPLSWNCEFGKFLKDYKIIKLAVDPKDRKNGLANLMNVLKESNVPNSTLRFIEKSALEGETMHATYDSDAHDVVKKEIENDKKIREWLKRIYYLDFVIFDFDTTFINS
Protein: SET domain-containing protein (Q57YP8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- C2H2-type domain-containing protein
- C2H2-type domain-containing protein
- Uncharacterized protein
Sequence:
MPGCLEVRYIGESHGVGSYTLKPAKAGDVLLQEYPVAFAKAQRQDALEPHRICGGCGMILTSLKEECRRLALLALEATTGGSSQLDERVHGSSNACEEQKYEHEAVGNRAGVTECAVEAPELAVIVSPDKLYDTFKDHEMWEHFQKGVEASDDIPEGGADSAEVRFCSMECKEHCLGGRGGRFVLPLLREPPCNELQLTSGVMEAQGIEDVDKLRTPSADTIMYQSTTLTAEVAVEVWPTKAHALATLEFLAEKYNARLRLVLFILARFLSDILSTGSVAANKQFEERLGERVQEFVQHYDEGASRGLSPEQRSFLRFSWKCVCRWITLCCVNEGKVATAVAGSEDKFCEGLCSAERVCSSTAEWFPLQLYLRCFWVTDANAHMYVVVSPLYSLLSERLPILSGIYRIQSETHFGKGRGENVCENEDSNVGSGREVDRLNRQMKILQFLFQTVDPNRAHSRGVALYDAAAKINHSCAPSVRFVPTHGGVKAVVVALRDIPSGEEVRTSYIEVGAYPTNKARREFLLSSYGFNCDCPLCVTECEPT
Protein: Inositol-tetrakisphosphate 1-kinase 3 (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase 3) (AtItpk-3) (Inositol-triphosphate 5/6-kinase 3) (Ins(1,3,4)P(3) 5/6-kinase 3) (EC 2.7.1.159) (Q9SUG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 to form InsP5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 or a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4. Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity).
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Inositol-pentakisphosphate 2-kinase
- Inositol-pentakisphosphate 2-kinase
- Multiple inositol polyphosphate phosphatase 1
- Inositol polyphosphate multikinase alpha
- Inositol polyphosphate multikinase beta
- Probable 3'
- 3',5'-bisphosphate nucleotidase 2
- Probable 3'
- Inositol 1,3,4-trisphosphate 5/6-kinase 4
Sequence:
MKLTDNEEITMNGTREMETTEQETSSPCSLVIEAFPVKKSIIVGYALTSKKIKSFLQPKLEGLARNKGILFVAIDQNKPLSEQGPFDIVLHKQIGKEWRRILEEFRLAHPDVTVLDPPDAILHLRNRQSMLQCVADMNLSDSNGRVGVPKQLVIKKDASSIPEAVNNAGLRLPLVAKPLVADGSAKSHELSLAYDQHSLLKLEPPLVLQEFVNHGGVLFKVYIVGEAIRVVRRFSLPDVSRRELPKSAGVFRFPRVSCAAASADDADLDPSIAELPPRPLLERLAKELRRGLGLRLFNLDIIREHGTRDRFYVIDINYFPGYGKMPEYEHVFTDFLLSVVQSQCKKRALADQY
Protein: Transcription factor STP2 (P38704)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3. Binding to promoters is facilitated by DAL81 (By similarity). Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000269|PubMed:12502738, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15197729, ECO:0000269|PubMed:16735580}. Note=Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids.
Interaction partners:
- SPS-sensor component PTR3
- SPS-sensor serine protease component SSY5
- SPS-sensor component SSY1
- Transcription factor STP1
- Probable ERAD-associated E3 ubiquitin-protein ligase ASI1
- ERAD-associated E3 ubiquitin-protein ligase ASI1
- Transcriptional activator protein DAL81
- Protein ASI2
Sequence:
MPILSLSSTRNSVLTRIYDYLKALVQQVIVPNVEDDKSSKSTPFEKLEPAKQNHPQKDCCATEKDDLVDVSELFPKQNNKQLSLTSKSSVVPCALNLDNLETPFSIKIDNNGAVTTQLNLDEPILRGPSRGEPAKLQNDLISSPPLEESYINNDQYKALFPSNFLPITPVSSVITPASKKSIDESPLSDEVQGIADESSETLPYICHYCDARFRIRGYLTRHIKKHAKRKAYHCPFFDNSISQELRCHTSGGFSRRDTYKTHLKSRHFTYPEGVKPQDRNKSPGVCTQCGEHFSTSESWVENHIEAGSCKGLPEGYSEGIREKKKTSKMKMIKTSDGQTRFISSDESVSEPALQNKNCIEATVMQSKERPNDKIIPTKTEKNDFGIGTQWFERKQISRPTQTTQSRGPTEVQNLKEWSIISPPILSPQNASSVPQEYQSSRYTLHMDSPALSSASSALSPLSGDPITTTETNKSYPLDSEQSLLEPDKTEEDAINQSKESNMISINEMLQKQMDFELLGENHLKETQDYLALYKKAYGIEF
Protein: Leucine-rich repeat-containing protein 73 (Q5JTD7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLPSSIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLSEGEEEEEVAGGAGDTQEWERGREPAAHQRGSSSWMCPSDPSSQMVLMTSGLGDSLLAETEM
Protein: Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) (Q9R1K5)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Interaction partners:
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 7
- Anaphase-promoting complex subunit 5
- Cell division cycle protein 23 homolog
- Cell division cycle protein 16 homolog
- Serine/threonine-protein kinase PLK1
- Mitotic spindle assembly checkpoint protein MAD2A
- F-box only protein 5
Sequence:
MDQDYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEHKGLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR
Protein: Sterile alpha motif domain containing 4B (M0QZ22)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRSRPEPSYHSRQGSDEWGGPAELGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLIPTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGGPSRDLC