wanglab/gogpt-training-data huggingface dataset:
Protein: Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-) (Q6PCB7)
Organism: Homo sapiens (Human)
Function: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Endomembrane system {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Cytoplasm {ECO:0000250|UniProtKB:Q60714}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes. {ECO:0000250|UniProtKB:Q60714}.
Interaction partners:
- Diacylglycerol O-acyltransferase 2
- Beta-alanine-activating enzyme
- Long-chain fatty acid transport protein 4
- Scavenger receptor class B member 1
- Long-chain-fatty-acid--CoA ligase 1
- Acyl-CoA wax alcohol acyltransferase 1
- Platelet glycoprotein 4
- Hydroxysteroid dehydrogenase-like protein 2
- Lysosome membrane protein 2
- Peroxisome proliferator-activated receptor alpha
Sequence:
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
Protein: Stomatal closure-related actin-binding protein 3 (Q8GX05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable plant-specific actin binding protein that bundles and stabilizes microfilaments (MFs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O48791}.
Interaction partners:
Sequence:
MTKVCPEIEGTLSLSVVPVSVDVSFASDHFPTYKLGPDNQIVEEPKEDEKGPSVKETVEKESELLSDQHKRLSVRDLASKFDKNLAAAVSLANEAKLREVASLEGHVMLKKLRDALEYMRGRTDGQNKQDVETAISMVEALAVKLTQNEGELIQEKFEVKKLGNFLKQTSEDAKKLVNQEKSFSCAEIETARAVVLRLGEAFEEQERISEASRAQGPDVEKLVEEVQEARQIKRMHHPTKVMGMQHELHGLRNRIQEKYMNSVKLHKEIAIIKRVEESKSCPFVLEGKQSLGSCLRIRVNAQDNAPDLSNCSIQWYRAACETSRREAISGAIQSMYAPEPFDVGRILQADILSNGQKFTVTTDDPVDPDSGLPSRVESLMRKSNSEFSVVISQMNGQDYASRSHVFTVGKTRIKLSRGWITKARELYSTSMQLCGVRGNIKAPTKAVFWQPRKSLTFILTFESEHERNAAIALARKYAFDCSVTLLGPDD
Protein: Arylsulfatase H (ASH) (EC 3.1.6.-) (Q5FYA8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Arylsulfatase K
- Formylglycine-generating enzyme
- Arylsulfatase I
Sequence:
MTRNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASRNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPFLLLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEEKVASLMLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDHEFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGDVTYHDPPLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWLQPCCGTFPFCGCDKEDDILPMAP
Protein: GH20168p (Q8SXA6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MLVAGNTAHGVYRRSTDIKHFIDVQGVEELHQHSSEGQQLKLGANLSLTQTMEIIRTTSKQPGFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALKNAADEKEMSLAEYLGTNDKKLVLKTFVLPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLELEADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDASPAYRSKLACGLFYKFLLKHAPVAEVGEKFRSGGQILQRPLSSGLQVFQTQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTADQAHRAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFSEQPDKEVRGIFQMGLQYHFTMEPQTTVAIPFEDGLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAGWSPNESPIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEVRLANIAAGNKISELLPQFLESREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPIFYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKDASWIETVEAAYGKSINLIASDHYKKGDMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETLVVNAGHEAASFRLK
Protein: Protein MCM10 homolog (Sensitized chromosome inheritance modifier 19) (Q9VIE6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA replication licensing factor Mcm6
- Double parked, isoform A
- CDC45L
- Chromosome transmission fidelity 4
- DNA replication licensing factor Mcm5
- Cell division control protein
- DNA replication licensing factor Mcm2
- DNA replication licensing factor Mcm7
- DNA replication licensing factor Mcm3
- Origin recognition complex subunit 2
Sequence:
MGPAQKSGTDISIDDEEEILALEKLLGAAENENTKSAESEKAKPTAPILVPKLREDNSFANAFTFEKIVKPEKQKNAAIIKEPELDSSDDEEVKNFLERKYNEYGSDINKRLKQQQENAYESKVAREVDQELKKSIHVVTSTPQPLKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQSSAPVSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGVAYHIERGDLAKDWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKMSRRSELQSATAGRGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSMLAGYDVSPFAHTANHTSKPKTAEPTKIPYAERGGPVSRLAGGVEASRKQRVQDLERLRLLKEENERFEKKKQAEGHVLGSDNKKESEAGTPAVSMPTTPVPDKFKNRGFSFDASLTPKLSGSENFSFEINVGSRQAQNAKLKAAALLKKKPLEKINPNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKVVDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREKKILTGRETLSVRGDEETFMGCLAGSANLNLLVPDEE
Protein: Uncharacterized protein (Q387U6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLFLEPEVDYFRMQLHHLAIPTSICIPSVPKTSRNPETRANGDQECETGGENAKVDGTVPFITQEEQNKVIQRALRVALYQRFPYESYDTLENVYILAVTHLALPLIGDTGLSYEDLATLEICEHSLPPELRHRTFPSHLNALIAQRNPPDSGSVIQDRMLDHSATQGSSEEGTGKQRFNDSYFILIPDLTDEQAMVYCKGRQYAGSMLGSGKASVGPASDAARFSRSTLWDDARHSRANALEGPSEDLLSFHVVEGDMIHYVETSQGGLSEPAPRSLRFAAFKVALSQFSFEEQQYYTKKREEVRSHGSTTTLWGSTLHSSEANEVHINKTVRTILASEVPGRWRAEEEEAMKKFFTKCNSVLRAYSTPSSQMDDASKGDGGVLAPKQPGASVSDEHKTRNVAESLGQTERLSHLYGVRRLVYSFAACDCYHLVAEDNNPLYYAKSSRATYKPHTVNVTLISDLTVSPRLTPAFSASPQRCLGARIGTTKTVEGLVVSNQPSRAQSPDIKPCTVGEKFSVGSKRHSQSPGVSPPTSGAHGSDSHAPLQRLPSNTEGYLRLTTSLVCNNVSGNLKHRKENLLEKGLSFGRLNPCHEQATEGNVKCSNEKAVCAGDVVNLFRLLATSSIAQHQLRHNVIRPVISAAVLDSSGNAGTRGALHRHYQRIKCRALLDHTWYSIPIQPVPSTQDEVQWIPIVFGSAECISDVGYRTAVHIGFFPNAEVTDDSVRGNPLRPKGTAFATDVSKQSASPGTATRSAMMPLDTNHATLQTSSSDGSKGLCFSAQLKTAVSSSNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNKGNEEVPAGVSARRGGVAMSFNKGNEEVPAGVSARRGGVAMSFNKGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFNTGNEEVPAGVSARRGGVAMSFDTGNLTGVGSGNVACSSEREIVLRRSAMEGGSGWEQRCSSALFSPRPYRPTSLRVWEPGADDQSNSNRFEQGTRVTCAGPPAGFSATSTPWWRLPSQGPRRGDGVNAGRGECSTGGFCNDWQQCDTCGGRFPQGSTSNPRFCEHLQSRPTSVLNTYGKFSRSHSPHPSYNAMQQRQTQHYSTMGRDGRLRPPHTDRWDSNDVNGDVSPRTATDPLRGTFWKSPTLNPSNHRNGADPLLSPLSSPSCSGVLTPNAGRRPTIGEFAATNTRSSAFNCLASFKHHGAATETGNRTASGLENNYHGPSFCKNRAGVPTKRSVVPTFGRMDTLYDNSASGIPIYNEYGYPQGDSRVRPRGMQVMDMMYDRQWQRTQPPARLPVGAGPTNRGSLSTSWTNTTKNGVCGMRRACLPGKPPLASTRPNGASNTLNNGIAPTAVRRLTLRERIQLQRRLQQREANISAFETNIKENYCVGNDVKRFRTDVGDLSSANKTTASNGGERTTTETNSACGARTAAALAAVTFGGDPPSKGSLHSIGKDIMRLKSLTSPFAEADGVNVSFCLRDLTNAFLRMPQSEIKEYDLSKAAWLEDGVSCFVSAKPTKFNGEFENYVRHFNFHQHPFYLRERAFLFVLRVPTQPQLRLIIAVHNMHDFLSVLRQRPLRPLESWRGPHSMEEEMGGLSGRENASQLPADECNSGRTRTFLQRLCKFMKNCISGGNGGGTQQMGWAPITWGQRLALLRIQASAAVHGQAWSECTTPLLTDPVVLYSRMSFLSNRTASFAVLRCQLDTLKAFASTWIKSKRTTADENQVRMIQNRISKVESIQLGCDAPTAGIGEPKTSSSGVQAAGRVQQRLRSLPLRKRMGAPFAWKKADTTSNSVEKKGETQRQPQLKSTISSYSSSASLCRSKPEVGGANSSTPPGGVPASDAAGAATPLADADGTLIRIAERLTSSTDIVSGNNHFPPMRTILKLVTLWEQNAQRQRAFNDCPAEPAPYSYGGSDTVLASNLGARAELRDHQDDYDISVSHIQQLLQWQWEYHQNSYEALSLPVFRGALVASRGCRYGSDACSSVDPKVMGVNPLSRSLLLALVKWGWLVPIDYKALHKRAVRHTAVGDNMLSRVQFGFGVRRRTLFVGVLGFTCYRGWALSLLILYAAYRCFKLAAVGLLSTGAPWPAPLHSGTSIVYSRSEAAVEAMLEERQHFLSQLLATRVLQTQHYVHNFASRLDMLLRGYSPILSLIIGIELLFVWIFFACWSGAARVSATFGVNIDLLHQYMSELISPLPLYDNVMWCLTYMKPNVAGVETFSLVAPLFVVLCLMTQSPLRWVLYKTWEMFLHDDALVRRPVLSF
Protein: Probable cellulose synthase A catalytic subunit 9 [UDP-forming] (AtCesA9) (EC 2.4.1.12) (Q9SJ22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Xyloglucan glycosyltransferase 4
- Glucomannan 4-beta-mannosyltransferase 7
- Glucomannan 4-beta-mannosyltransferase 2
- Cellulose synthase A catalytic subunit 3
- Polygalacturonate 4-alpha-galacturonosyltransferase
Sequence:
MNTGGRLIAGSHNRNEFVLINADDTARIRSAEELSGQTCKICRDEIELTDNGEPFIACNECAFPTCRPCYEYERREGNQACPQCGTRYKRIKGSPRVEGDEEDDDIDDLEHEFYGMDPEHVTEAALYYMRLNTGRGTDEVSHLYSASPGSEVPLLTYCDEDSDMYSDRHALIVPPSTGLGNRVHHVPFTDSFASIHTRPMVPQKDLTVYGYGSVAWKDRMEVWKKQQIEKLQVVKNERVNDGDGDGFIVDELDDPGLPMMDEGRQPLSRKLPIRSSRINPYRMLIFCRLAILGLFFHYRILHPVNDAFGLWLTSVICEIWFAVSWILDQFPKWYPIERETYLDRLSLRYEKEGKPSELAPVDVFVSTVDPLKEPPLITANTVLSILAVDYPVEKVACYVSDDGAAMLTFEALSYTAEFARKWVPFCKKFSIEPRAPEWYFSQKMDYLKHKVDPAFVMERRAMKRDYEEFKVKINALVSVSQKVPEDGWTMQDGTPWPGNNVRDHPGMIQVFLGHSGVCDMDGNELPRLVYVSREKRPGFDHHKKAGAMNSLIRVSAVLSNAPYLLNVDCDHYINNSKAIREAMCFMMDPQSGKKICYVQFPQRFDGIDRHDRYSNRNVVFFDINMKGLDGIQGPIYVGTGCVFRRQALYGFDAPKKKQPPGRTCNCWPKWCCLCCGMRKKKTGKVKDNQRKKPKETSKQIHALEHIEEGLQVTNAENNSETAQLKLEKKFGQSPVLVASTLLLNGGVPSNVNPASLLRESIQVISCGYEEKTEWGKEIGWIYGSVTEDILTGFKMHCHGWRSVYCMPKRAAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPIWYGYGGGLKWLERFSYINSVVYPWTSLPLLVYCSLPAICLLTGKFIVPEISNYAGILFLLMFMSIAVTGILEMQWGKIGIDDWWRNEQFWVIGGVSSHLFALFQGLLKVLAGVSTNFTVTSKAADDGEFSELYIFKWTSLLIPPTTLLIINIVGVIVGVSDAINNGYDSWGPLFGRLFFALWVIVHLYPFLKGLLGKQDRVPTIILVWSILLASILTLLWVRVNPFVSKDGPVLEICGLDCLK
Protein: Integrin beta (A0A8I5ZKE8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
Interaction partners:
Sequence:
MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSIISRCDLKANLIRNGCGGEIESPASSTHVLRNLPLSSKGSSAMGSDVIQMTPQEIAVSLRPGDQATFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASDQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGLSYPGQRKCEGLKIGDTASFEVSVEARSCPGRHTTQSFTLRPVGFRDSLQVEVAYNCTCGCSAGLEPNSARCSGNGTYVCGLCECDPSYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHVGYIGDNCNCSTDISTCRAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECSLLHQGKPDNQTCHHQCKDEVITWVDSIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGKSNLTVLREPECGSAPNAMTILLAVVGSILLVGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSVD
Protein: MAP kinase kinase kinase win1 (EC 2.7.11.25) (O74304)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation.
Interaction partners:
- Response regulator mcs4
- Protein kinase wis1
- MAP kinase kinase kinase wis4
- Peroxide stress-activated histidine kinase mak2
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Tyrosine-protein phosphatase 1
- Multistep phosphorelay regulator 1
- 40 kDa peptidyl-prolyl cis-trans isomerase
- Peroxide stress-activated histidine kinase mak1
- M-phase inducer phosphatase
Sequence:
MENILDPSVVNSHILENGSRRSSINPILDSELRDKTFEKAHRRSLTLLSSFTSSMLELPNNGKEENHRRPSVARSSSDRSKASAKEDLFSEAFRMAEQPPAEALTISTPVDPINIDELDRAYAVSPSDTSNLLHPPTSSSSIPIPIKNAGHSNLDHPIRPSLQSSISSNRIIKSPGIKEDDYMHRGRSISSPMIDVEHINSTAVPSKTKNLPEKPKRSHKLRNSITFAKIEDHPERKSQLRRLSSSLKCFDPEYDYNDPSLSIRRDSSTYYFSNVNETYDEEDSDLDSETSTVNWVQSVLNLPSLLSDDLMANPKNKERFEWQYMLTSVLTGDIVRSEKLRLRKIASSREGRNSDYSDNLWMEIWCWLTHRSVDSYRENLKHLRTGMVDVLLAIMNFHWDESNELTPIVAVDNMLQKLDKYERLYPSRRSILQEHSLYASESFQHKLDVLTAYSNVTHALEIQVNIIRSWVGNEEMDITKNTTNSINNVSQISNGPFVERFYRETGLIRAFEQRIMTNMNSVLSKVCNTIVTYADDLKSYGLPLIADDYMRLLSFPFRLIKEFLNLRLSCAENITSISLFTIDSLLDDLRNTMKVAVHIIQQHTVLIKPFRDDSKFVDENQSLNNILVASLKFYFNLLHRKVRNGCALLHFKETEILEGEWDFLLAVCPHIEHGFQIMSKSLSSLVGEILTNINRYLKDQLQGPDTDDSALITSFYIKVLDCVRIRFRKLMSFTRILKAHLENSCEYVIKENSLSLLIQRLEESNHVLTYTASIEHEGAYVIVPGHLVDSPNILREVLSMTFNKGDNNFESVPPYAVVLAPDSSICWNGHVTDLDIPEVSISIAPNCVRLVTLATANQLSVIEDYFISIVGDTVSLVDSAKANSSKINKQMTKIKRNSLKLALSLLDVIQTIRTRYHGMNCQNLIHYSFSYAIEFAQRLMRLSILDASSIGLIRRKMIQLAISWVGFIYEDCSPTDRNTFRWTVTALEFAMIMTYGSNILMIDKKSFEELKEKVGKCVALLLLHFDVMGTKHAGRSMDQQAGDIPARLVRNNSDRSRLSDNELASFVKEEVMHRIIELESNRRDRLYKSQLIGRVLDDTTKENRLLKELASSKSNITIRWQQGGLIGSGSFGTVYRAVNLDTGDLMAVKEVALHKPRISRPMIKRIKGEMLVLELFDHPNVVSYYGIEVHREKVNIFMELCQGSSLFEFLRYGRIEDELVIQVYVLQLLEGLAYIHSCGVSHQDVKPENILFDHNGIMKFTDFGSAKMSGSASTKIFEQLTQQEEEEFEKDSEFLQHLDQNRGYSLTGTPTYMAPELILGNPSERVGAMDIWSLGCVIVEMATGSPPWPRLDNHFSLMYHIAAHNPPIIPADDQLSPLGQNFLKRCFVSDPNQRATAAELLMDPWVYPLRAGTEFDLMNSSVVESAPSTNGAPLEL
Protein: Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) (Q8CF90)
Organism: Mus musculus (Mouse)
Function: Transcriptional factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12368292, ECO:0000269|PubMed:12917329, ECO:0000269|PubMed:14973194}.
Interaction partners:
- Pancreas/duodenum homeobox protein 1
Sequence:
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGQSFAGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAKGAPDFFL
Protein: Activated in Blocked Unfolded protein response (Q19594)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRFIAIAALLASSLLLIETTSIREKRQSCGCAPKVQPSCSCQQTPYTQPQETSCSCQNTAPVQTSCSCAQPVQQQTYLVPTSQCAPACQQSCQIHCHSAPFVQECQSSCQQSCQTTSCYTPPAPAQCMPQCQQQCSQQCVQTQPVQHCQSQCHQQCVQRCAPIVAPQLININLEAPAQCSQCQQSCQQQCVQQQYSVQQCNQHCNLECQPTCQQAVSQCQQQCAPQCQQPSAPQCQQCQSSCQQTQQCQQQCIPLCNQPSAPACQQCQSACQSPVVAPQVVNVMLDVSVAQSAQCQPQCQQSCQQQCIKQQYPVQQCIQPCTVECQTACQQAVPQCQQQCAPQCYQPSAPQCQQCQNTCQQFAPVCQQQCASQCLQPAAPQCQQCQNTCQQFAPVCEQQCASLCHQPSAPQCQQCQNTCQQFAPVCEQQCAPQCYQPSAPQCQQCQASCQQTQQCQQQCIPQCQQPSAPQCQQCQSACQFPVVAPQVVAVILEASVSQSAQCEPQCQQSCQQQCIQQLQPIQQCATACTQSCSQSCSAAQPAQMPCITQSANSCSCQQNYSPCGNGQCCKRR
Protein: 5'-AMP-activated protein kinase subunit beta-1 (A1Z7Q8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- non-specific serine/threonine protein kinase
- LD22662p
- Serine/threonine-protein kinase STK11
- Raptor, isoform B
- Serine/threonine-protein kinase mTor
- Forkhead box protein O
- AT25266p
- LD44138p
- AT03158p
- Tribbles
Sequence:
MGNASSSVHMQRERHKSTDLSTPSSPAHFRDSIGGGGAGQGGSAGAAALGAAAGAVGAAGGGGGGGGGQAFSFDKKHTAVLNEGSSQEDDDPYYTGTGTGSTRRGTAHDDATSAVTRDHSSMDNNEEEEEAAVGAEPATGSQLTGDEDDIRKTALPTVLRWDGGGKNVTISGTFSDWKPMAMVRSHQNFVTIIDLPEGDHQYKFCVDGEWKHDPKLKSVENAEGQRNNLVSVRESDFEVFQALAKDSENVTNYAEKEYSQEVPQVKPWEKVSGPPVLPPHLLQVILNKDTPLSCEPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPI
Protein: Uncharacterized protein YjgL (P39336)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YfdF
- Inner membrane protein YjgN
- Uncharacterized protein YkgH
- Isoleucine--tRNA ligase
- Toxin-antitoxin biofilm protein TabA
Sequence:
MSKISDLNYSQHITLADNFKQKSEVLNTWRVGMNDFARIAGGQDNRRNILSPGAFLEFLAKIFTLGYVDFSKRSNEAGRNMMAHIKSSSYSKDTNGNEKMKFYMNNPVGERADSPKVIIEISLSTITTMGTRQGHTAIIFPQPDGSTNRYEGKSFERKDESSLHLITNKVLACYQSEANKKIARLLNNNQELNNLQKLNNLQKLNNLLKLNNIQGLNNPQELNNPQNLNDSQELNNSQELNSPQELNDPQELNNSQDLNNSKVSCTVSVDSTITGLLKEPLNNALLAIRNEHLLLMPHVCDESISYLLGEKGILEEIDKLYALNDHGIDNDKVGNNEINDIKVNLSHILIDSLDDAKVNLTPVIDSILETFSKSPYINDVRILDWCFNKSMQYFDDTKKIKHACSVINHINLRSDQSKIAETLFFNLDKEPYKNSPELQGLIWNKLVVYVNEFNLSNREKTNLIQRLFDNVESIFNEVPVSILVNDIFMNDFFMKNPEMINWYFPQLLKSYEGEKIYFDNLKYDLNDNDKESNKEILKNQPDNVIKEKLNNEYKLRFRMMQTILQSRVNVLPYINEQRLNKLNPPENLRIAIEHFGWKNRPITA
Protein: Protein transport protein sec-16A.1 (Secretory cargo traffic protein sec-16A.1) (P34643)
Organism: Caenorhabditis elegans
Function: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). In association with tfg-1, accumulates at ERES to positively regulate secretory cargo trafficking from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi apparatus.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:21478858}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:23840591}. Note=Co-localizes with tfg-1 at endoplasmic reticulum exit sites (ERES). {ECO:0000269|PubMed:21478858}.
Interaction partners:
- Protein transport protein SEC23
- WD_REPEATS_REGION domain-containing protein
- Protein SEC13 homolog
- Yeast SEC homolog
- Protein tfg-1
- WD_REPEATS_REGION domain-containing protein
- Protein transport protein Sec24C
- Small COPII coat GTPase SAR1
- Putative syntaxin-5
- t-SNARE coiled-coil homology domain-containing protein
Sequence:
MRRYRIDSMKYEQRMNAGASGFDMSDWNNPYNASPPSSRGGDDDASSVNHSRPRRSRLDNDIPQPRRPILIQPARPVSQKSNRQGTGMSNGSRGLNSTFNGYDRTYSRYHQNSSRGPSEGFSGAPSARNASGYASDYANSRAGVGLLPNNHREPVRPRSTAAERYANASSMRNGFVYDSGESDKTSEELEEDEEEEEVRNFYMEGRAQGSRSVTNTLASEVYNSESESYYYGVVKLGSAIVDHVFRTMPPPEKYYKMPPIDRVAYVFYCAVNNKPYNNIDEFHVIFNREFYSYRGYGDSKDLALFKVCKRMQEEFSLKQLEADRLAYEKARQEAAESEKLDFNQHKIEEREEPKLNISQPEEVLSNGPLHYHSCLQFATIGVGGKLVIIKPAGTIDSITGHVLSTSSVHVDDLKTFLHFDEQSGKVIESVQNFKGPLIAGQTPTHSVRLYIQRQIDALRQIRNAGDVKKSEVVDALLVWQLLEIMVQQHGRVTGPDVATLLTNASEELGEKTGISSNGTSESGSKFEAKERFNKYLLGGHINEAVESAITDGLYADAMTLIRRLHPNDAKKIEEIEARFMNLRSIDDPFATLVAVSSDQPPPILTNSAFDDDNNWKRHAAIVLANLNSQTAMQTIYHLGLLLAKRERNCAADFCLLVVCILAGYDPFIPVAHDGDETSRKHIGLVHSGSNLLNRVDGLSGTAGFSFTDLHATDIFDYALRLGNNNVDSPLAKSIDYQLARIEYAKKLSSFGGFATDAFRYCTEVARSLWMYVAAFDKNAMFDLCDLAESLQYMAAATPDESGWITTMRGMLGAAPVQESQQHVPQPQPVENKSISSEAKKWHDEHQAPLEIGSRNDQQHNDKTVEKPIAPGRASLPPPTLVTESSSESTFTDKSDSSVTVAASASRTSTLTSSTLPPPPSLPKTIEKPISTPPPISKNVVPEMTPPAIVKPPMPTLSMPIPPVSTPIMVSPQPIPIPKPVDASIAKSPRSELDDLWDTSPPSNQTSYPPAPRNIQPSYSPAPNFANPTAPSVPTPPPAVSSAPVLQQATLGQASIPNAKTTAPPVPQKQPELALNERKASKGWFGSIKEKVIKSIPSANQMILPDDSKPSIVWDPVQKRYVGAGVEEEVVAAPPPVMSAPHLMGGGPDSNKSSTNSLRSARSGVGSRYLQSGMATSQAPAMDTGMPPMMPPTMPMSFSFMPAPTEDDSSEYVDPFSGEPTAPSESLSKQNND
Protein: Glutaredoxin-2, mitochondrial (Q9NS18)
Organism: Homo sapiens (Human)
Function: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Subcellular location: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Interaction partners:
- Glutaredoxin-3
- Ribonucleoside-diphosphate reductase large subunit
- Thioredoxin reductase 2, mitochondrial
- Thioredoxin
- Low molecular weight phosphotyrosine protein phosphatase
- Glutathione reductase, mitochondrial
- Mitochondrial peptide methionine sulfoxide reductase
- Glutaredoxin-related protein 5, mitochondrial
- Thioredoxin, mitochondrial
- Inosine triphosphate pyrophosphatase
Sequence:
MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQIQETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERTVPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ
Protein: cDNA, FLJ92342, Homo sapiens apelin (APLN), mRNA (B2R550)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSATWCSPEGQGMGQGPGREVGGNSAASGPASPIRDPCLSEAGLKGPPSAHPRRLCLLHRLVCFSGGLTSIQLSPRTCCSHQWAQLFSPACFPQWRAPGCSLDDSRSLTRIRPVHLPGPSLD
Protein: La protein homolog (La autoantigen homolog) (La ribonucleoprotein) (P87058)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to the precursors of polymerase III RNAs. Functions in tRNA maturation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Exportin-T
- Repressor of RNA polymerase III transcription maf1
- Signal recognition particle subunit srp72
- Signal recognition particle subunit srp68
- tRNA
Sequence:
MSTEEQKEEIKDISSKQENSSEVPKAEEAGKVVESQKDTTSEEKKEETTEKKEDDGKKDLSFDEAEVLKQVEFYFSDTNLPHDKFLWTTSQKNDGWVPIQTIANFKRMRRFQPLEAIVNALRKSPELLEVDEAGEKVRRMIPLVRVDNKSVMERSVYCKGFGDEKDDTQIALEKFFEENAGPISAVRMRRDDDKKFKGSVFVEFKEPDVANKFLEKVKTAPLKWGEDELTIMSKKEYVDMKAELHKNDPPKFSSKRRRFDAFKEMDRQRPGKYSNRGRKFKKQRSSNASEEKPSAASE
Protein: ADAMTS-like protein 2 (ADAMTSL-2) (Q86TH1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Latent-transforming growth factor beta-binding protein 1
- Fibrillin-1
- GDP-fucose protein O-fucosyltransferase 2
Sequence:
MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS