wanglab/gogpt-training-data huggingface dataset:
Protein: Phototropic-responsive NPH3 family protein NPY5 (MAB4/ENP/NPY1-like proten 1) (MAB4/ENP/NPY1-like proten 2) (Protein NAKED PINS IN YUC MUTANTS 5) (Q0WL52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21490067, ECO:0000269|PubMed:33705718}. Cytoplasm, cytosol {ECO:0000269|PubMed:21490067, ECO:0000269|PubMed:33705718}. Note=Observed in the cytosol and in apolar aggregates close to the plasma membrane in root epidermis and lateral root cap cells when PIN2 is absent (PubMed:33705718). PIN1- and PIN2-dependent polar localization at the cell periphery almost identical to PIN proteins polarity, in the upper side of the plasma membrane towards the tips of cotyledon primordia in the protodermal cells and in root epidermis, and in the basal side of provascular cells, root stele, pericycle, endodermis and cortex, and in radicle tip cells; this localization is enhanced by PID (PubMed:21490067, PubMed:33705718). Weakly observed in the cytosol of root tip quiescent center (QC) and columella cells, sometimes close to the basal side of the plasma membrane (PubMed:21490067). Apical and occasional cytoplasmic localization in root epidermal cells (PubMed:33705718). {ECO:0000269|PubMed:21490067, ECO:0000269|PubMed:33705718}.
Interaction partners:
- Putative defensin-like protein 129
- Probable indole-3-pyruvate monooxygenase YUCCA1
- Alpha/beta-Hydrolases superfamily protein
- At1g31760
- Protein DETOXIFICATION 37
- Serine/threonine-protein kinase WAG2
- Rop guanine nucleotide exchange factor 5
- Protein IQ-DOMAIN 18
Sequence:
MKFMKLGSKPDSFQSEGDNVRYVSSELATDVIVIIGDVKFYLHKFPLLSKSARLQKLITTSTSSSNEENQIHHHHHEDEIEIAEIPGGPASFEICAKFCYGMTVTLNAYNVVAARCAAEFLEMYETVEKGNLVYKIEVFLNSSILQSWKDSIIVLQTTRALSPYSEELKLTGRCLDSIASRASIDTSKVEWSYTYSKKKNLDNGLRKPQAVPRDWWVEDLCDLHIDLYKRALATIEARGNVSADVIGEALHAYAIKRIPGFSKSSSVQVTDFAKYRALADSIIELIPDEKRSVSSSFLTKLLRASIFLGCDEVAGLKNRVGERLDEANLGDVLLYDVELMQSLVEVFLKSRDPREDDVTAKASVAKLVDGYLAEKSRDSDNLPLQKFLSLAEMVSSFPRQSHDGVYRAIDMFLKEHPEMNKSEKKRICRLMDCRKLSAEACAHAVQNERLPMRVVVQVLFFEQVRANNNGSSSTGNSTPEVIPASRSTNTTDQEDTECWDTEDIKALRGELANLRLAKNQQESHNQGKLMKGGGLGVSRVFSKLWSGKERSGDMISSSGTSSPGSVNDDSKSSSSTSKKH
Protein: HMG box domain-containing protein (Q9FLC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSRVLSVKRTLAENPLSLKCAIDTNRKNRRCALMAIRPRTRKRVQAVRRAADGSAFKKCEECGVMIAIALYDMHECGEKRREVKRFKYIASGNIDNISKPIGSFEDEPRSPFVFFLEEFRENYNGDLVDASRICFNVWKNMSAEDQKPFNARAMEVDSAHSRKLNEEAKTIYKADEEADSKTVGRYDKFYESYVQIEEEEDYDSSDHFGHEFWEDDTMLDY
Protein: Cholesterol 16,22-dihydroxylase CYP90G4 (EC 1.14.14.-) (Cytochrome P450 CYP90B50) (PpCYP90B50) (A0A517FND3)
Organism: Trigonella foenum-graecum (Fenugreek)
Function: Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e.g. furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones. During the 5,6-spiroketalization of cholesterol, catalyzes the hydroxylation of cholesterol to form 16S,22S-dihydroxycholesterol and, possibly, the subsequent conversion of 16S,22S-dihydroxycholesterol into 16-oxo-22-hydroxy-cholesterol and 16-hydroxy-22-oxo-cholesterol. 16-hydroxy-22-oxo-cholesterol submit a spontaneous reaction leading to the production of furostanol-type steroid diastereomers, precursors of diosgenin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSNSYLSFFVLSSILVLTLIFFFMKRKKTKFNLPPGSMGLPFIGETFGYLKPCSATTMGAYMENRIARYGTIYKTKLFGEDTIVSADAELNRLIFQNHGKLFDTNYPKSIAEILGKWSILTIVGDVHRELRNVSLNFMSYARLKTHFLKDSENSALLVLNSWKENCTIEAQSEAKKFTFNVITKQIMSLDPRNPETEELRDEYLSFMNGVVSAPFNLPGTPYRKALKSRKIILKFIEGKMEERIKRNQEGKKDLEENDDLLNWVLKHTNLSTDQILDLVLGMVFGGYETSSAATALAMYFLPGCPKAIQQLREEHQAIARSKKKAGEVELTWDDYKKMEFTHCVVNETLRLGNVVRFVHRKSIKDVRFKGYDIPCGWNVMPVISAVHLNPSNFEDPQHFNPWRWQSGNWASLNSNFMPFGGGAKICPGMELAKLEVAVFIHHIILKYNWDLVDVDDKPIIHPLVDFPKGLRIRVQRQPTLI
Protein: Sin3A-associated protein 130, isoform G (M9PCC4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSAPSEGGAGGGPVGGGSTATAPSAHPAVAAKITHVKSDGGGGISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGAGGQSTQVRVVMPMIKQLENVTATGRTQITAIPAAPARSGANASITVTRPVTQATYLPRASVTATQMGGVGVGVGQRLVTPLRATSSATVTPTAPTVLSSTGGFVRGATASVSRSGVALTSQPSSAVISSSNSGAWMQSQGQVQLIRTIHQPRQRIITTSAGVSNASVVTTTPVQAPTALSVSAGQPLATQQATGPGGGPQAYVATVLPQRQHQATLVYSSNVSAPNASQNPGQQFNPRFAVATPTGGVTTTTPGGTTVTPRQVRPIPLGKSFPTAKLNTTSISIRAPSIPQLNTSVTASPTAVSVSGGATVAPGRGPGAGGTALTATNLPTTRIIQLQQPATGTTQQIIGSGARLAGNVMLQPFLMSTTAAAKMGIRPPVTMTAKVQPSLTITQLNPIGKLSAGGGSGGQTMGPQGVASIQAVPVPNVSASVVNSSSVTGATSAAGGATVLPLTISGRGAGVGPGGNILTGTLTPIKNASGITLGKMMMAPASSAPGADGSSTSGATVTGFQRTWNPVVASQSQLMKIDEKGSAATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATAGAGSGGGGSQATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQQATASGALVSSFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQSVGSGLTVEALAKKERERVTHGVASSAASVPATVGPVNSTRNSRADSPASSDGSTTVSANSSPGVDQQLQDRIGDQPATGGAGGRDNSTHFNPINEQNLGHSSLGARSGSSAFVDVQAPTPQQQQPQQVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKPRRSTNDSQHSTQSQASLSLPPPSSEPTPPAGASYMQKHNNGGLLVTAATPGVAPNSAPGDANHRNSTPAVAGNKENANPVDFVIRRPRNCALLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMEDLNESEVFSLGRLETMLQDLEKDKEKHSEIERVTELLKGNIQRSKIITDGINEAQNQLMKIFEHKPHVSNIITRCASKRNFKKREKI
Protein: Myristoylated alanine-rich C-kinase substrate (F6NXD5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
- Gap junction protein
Sequence:
MGAQISKNGAKDETAAEKPAEAANKSNGQENGHAKTNGNASPNAEAAAEDVQANGKHAADGEVKAEEGKAEEADAEKAAPEGEGESSAVANGEDSTKTEESAATSSEPAKTKKRFSFKKPFKLSGFSFKKSAKKEAEGGEAAAATAENGEQKKDAEPEEAKPEASSEEAKAETPAEEPKAEEPKAESSEEKPASEVAEEKPAEEKQEAAPQEPAAAESSEAPAAATE
Protein: PALM2 and AKAP2 fusion (B1ALY0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}.
Interaction partners:
Sequence:
MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQKAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTDVSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGVGWENVLLKEGESASNATETSGPDMTIKKPPQLSE
Protein: Malate dehydrogenase (EC 1.1.1.37) (B4FRJ1)
Organism: Zea mays (Maize)
Interaction partners:
- Citrate synthase
- Malate synthase, glyoxysomal
- fumarate hydratase
- Citrate synthase
- Citrate synthase
- Malate dehydrogenase, chloroplastic
- Aspartate aminotransferase
- Aspartate aminotransferase
- aspartate transaminase
- Citrate synthase
Sequence:
MRPSLMRSTSQLLRRRSYSSASGQPERKVAILGAAGGIGQPLSLLMKLNPLVSSLSLYDIAGTPGVAADVSHINSPALVKGFMGDEQLGEALEGSDVVIIPAGVPRKPGMTRDDLFNINAGIVKNLSTAIAKYCPNALVNMISNPVNSTVPIAAEVFKKAGTYDEKKLFGVTTLDVVRAKTFYAGKANLPVTDVNVPVVGGHAGITILPLFSQATPATNALSDEDIKALTKRTQDGGTEVVEAKAGKGSATLSMAYAGAVFADACLKGLNGVPDIVECSFVQSTVTELPFFASKVRLGKNGVEEVLGLGELSDFEKEGLEKLKSELKSSIEKGIKFANDN
Protein: Separin (EC 3.4.22.49) (Separase) (Q03018)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/PDS1 protein. It also promotes anaphase spindle elongation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Cleaves SLK19.
Subcellular location: Nucleus {ECO:0000269|PubMed:11149918}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:11149918}. Cytoplasm {ECO:0000269|PubMed:11149918}. Note=Accumulates in the nucleus in G2 and is mobilized onto the spindle pole bodies and spindle midzone at anaphase onset, where it persists into midanaphase. The association with MCD1 may be important for its nuclear targeting.
Interaction partners:
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- Sporulation-specific protein 12
- Securin
- Kinetochore protein SLK19
- Sister chromatid cohesion protein 1
- Protein phosphatase PP2A regulatory subunit B
- Tyrosine-protein phosphatase CDC14
- Structural maintenance of chromosomes protein 3
- Meiotic recombination protein REC8
- Protein BNS1
Sequence:
MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIEDITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWNDYYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKLPFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNMSENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDESAAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQSAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSRMIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMDFVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLHASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKIFNESAKLNIKAGNVISAVIDCRKAQNLALSLLKKKNKLSQGSRLALLKSLSFSFFQLIKIHIRIGSARDCEFYSKELSRIISDLEEPIIVYRCLHFLHRYYMITEQTCLQNITLGKANKAFDYLDAEADITSLTMFLYDNKEFVKLEQSLVLYFGDQLEKTFLPNLWKLHLGKDIDDSICLSEYMPKNVINRVHNMWQKVMSQLEEDPFFKGMFESTLGIPSSLPVIPSTMPNNILKTPSKHSTGLKLCDSPRSSSMTPRGKNIRQKFDRIAAISKLKQMKELLESLKLDTLDNHELSKISSLSSLTLTILSNITSIHNAESSLITNFSLTDLPRHMPLLFDKVLNNIDNKNYREFRVSSLIAPNNISTITESIRVSAAQKDLMESNLNINVITIDFCPITGNLLLSKLEPRRKRRTHLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQTTSVEVTNKIKTREERKSWWTTRYDLDKRMQQLLNNIENSWFNGVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPSRKLYGNPAMFIKVEDWVIELFLKLNPQEIDFLSKMEDLIYFVLDILLFHGEENAYDEIDFSMLHVQLEEQIKKYRATMTTNSIFHTFLVVSSSCHLFPWECLSFLKDLSITRVPSYVCLNKLLSRFHYQLPLQVTIEDNISMILNPNGDLSRTESKFKGMFQKIIDAKPSSQLVMNEKPEEETLLKMLQNSNLFVYIGHGGGEQYVRSKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDIDKFSEELFEKMGFRCNTDDLNGNSLSVSYAVSKSRGVCHLRYLNGAAPVIYGLPIKFVS
Protein: Probable tyrosyl-DNA phosphodiesterase (Tyr-DNA phosphodiesterase) (EC 3.1.4.-) (Q9USG9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA topoisomerase 1
- Bifunctional polynucleotide phosphatase/kinase
- Aprataxin-like protein
- DNA-
- DNA topoisomerase 2
- Mating-type switching protein swi10
- DNA repair protein rad16
- Crossover junction endonuclease mus81
- DNA ligase 4
- DNA ligase 3
Sequence:
MSTLEPEKRRQHEDKSNEIIDSPIFLNKISALPESENVHCLLLKQLIGSPQLKQTWQFNFCVDLNFLLENMHASVFPTVDVRITHGYDSKSDSLARLTAQMNHCPVNVKLYSVYVPMWGTHHSKIMVNFFKDDSCQIVIHTANLVEPDWIGMSQAIFKTPLLYPKANDSLSTSSVPEYGNPSKIRKHEGSLDIKDDRNCDIIDVDSAFENFKHKSDTRSSDDLGVIGRQFQQDFLAYLKNYRHTYELIEKLKMYDFSAIRAIFIGSVPGKFEGEEESSWGLGKLKKILKMLEKDSKKDEKTKFEESDICISQCSSMGSFGPKQEYIAELTDGFGCQRGNWKFLFPTVKEVQQSMLGWQSGSSIHFNILGKTAASQVETLKKGKNLCKWVAMKAGRQRVAPHIKTYMRFSNDGELLRWVLVTSANLSKPAWGTLEGHKAKSRSTRGLRIRSYEAGVLLYPKLFEESQRAPCIMTPTYKTNTPNLDEKRREFYGKRVIGVRMCWDFPPVEYEDKDEIWSPVINRTDKDWLGYVWPPNW
Protein: Structural maintenance of chromosomes protein (Q24098)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
Interaction partners:
Sequence:
MVHFSGICHIMRLLATQVVASDFVQKIAYNKMHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHEGTGARVISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKVFVEDDSTHA
Protein: Putative MO25-like protein At5g47540 (Q9FGK3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 19
- Putative beta-glucosidase 5
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Classical arabinogalactan protein 7
- Arabinogalactan protein 20
- Arabinogalactan protein 16
- Exosome complex exonuclease
Sequence:
MKGLFKSKPRTPADLVRQTRDLLLFSDRSTSLPDLRDSKRDEKMAELSRNIRDMKSILYGNSEAEPVAEACAQLTQEFFKEDTLRLLITCLPKLNLETRKDATQVVANLQRQQVNSRLIASDYLEANIDLMDVLIEGFENTDMALHYGAMFRECIRHQIVAKYVLESDHVKKFFDYIQLPNFDIAADAAATFKELLTRHKSTVAEFLTKNEDWFFADYNSKLLESSNYITRRQAIKLLGDILLDRSNSAVMTKYVSSRDNLRILMNLLRESSKSIQIEAFHVFKLFAANQNKPADIVNILVANRSKLLRLLADLKPDKEDERFEADKSQVLREIAALEPRDLA
Protein: Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) (P24298)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
- Glutamate dehydrogenase 1, mitochondrial
- Alanine--glyoxylate aminotransferase
- Glutamate dehydrogenase 2, mitochondrial
- N-acetylglutamate synthase, mitochondrial
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Albumin
Sequence:
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRTGVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQLPPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLLLEKLSRFHAKFTLEYS
Protein: MHC class Ib antigen (Q6W9J9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
METSAFFTLLFTLYLLLGASLALAQTFRGSHSLRYFDIAVSRPGLEETHYMTVGYVDDTEFVHFDNEAENPRFEPRVPWMEQMGQKYWDDQTRIAKAAEQQIRVYFQKLRDYYNQSQNSSHTIQRMTGCYIGPDGHLLHAYRQFGYDGQDYLTLNEDLSTWTAADAAAEITRREWEATNVAEFWRVYLEGPCMVWLFKYLTVGNETLLRTEPPKAYVTHHPRPEGDVTLRCWALGFYPSDIIMIWQRDGEDQTQDMDVIETRPAGDGTFQKWVAVVVPSGKEQNYTCHVAHEGLPEPLTLRWSRPPQSFIFIIIVAVGLVLLGASVATLVMWKKSSGGERGSL
Protein: Golgi apparatus membrane protein TVP23 homolog B (Q9NYZ1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- CMT1A duplicated region transcript 15 protein
Sequence:
MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFRVSAIIVYLLCGLLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKESSQENKTVSEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVRSRKHLTSMATSYFGKQFLRQNTGDDQTS
Protein: Set1 complex component swd3 (Set1C component swd3) (COMPASS component swd3) (Complex proteins associated with set1 protein swd3) (O43017)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The Set1 complex specifically methylates 'Lys-4' of histone H3.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Set1 complex component spp1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Set1 complex component swd1
- Set1 complex component ash2
- Set1 complex component sdc1
- Set1 complex component swd2
- Set1 complex component shg1
- Target of rapamycin complex subunit wat1
- Uncharacterized WD repeat-containing protein C824.04
- Polyubiquitin
Sequence:
MDSTAQQFPLNHDLQVQKDQKGVVEEDEEQIHKRIRNYESHSGFSEYCTLFGHEKSVTCVSVSPNKRWIATSSSDGTIKIWSALTFRLECTLFGHYRGISQVKWATGSKYLASASDDKTIRIWDFEKRCSVRCLKGHTNYVSSIDFNPLGTLLVSGSWDETVRIWNLQDGTCLRMLPAHSEPIISVSISADGTLCATASYDGMARIWDVLSGQCLKTLVEPINVPLSNLQFTENRKYLLVSNLNSQIRLWDYRRNRVVRIFDSHVNTRYSMSWDCYSSKNIPKNTEALPNNDSSYPDDAESFMHDAYLLIPSEDGTIQITDPSTKIIIDDSIRHSDDPETSLLNVTSLGPFIITSGTDPYVRVWAPSLLLSKHEKDGFSP
Protein: Myogenin (MYOD1-related protein) (P12979)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:16424906}. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.
Interaction partners:
- Transcription factor 12
- Myocyte-specific enhancer factor 2C
- Transcription factor E2-alpha
- Paired box protein Pax-7
- Myocyte-specific enhancer factor 2D
- Protein myomaker
- Myocyte-specific enhancer factor 2A
- Myosin-3
- Myosin-1
- Paired box protein Pax-3
Sequence:
MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARGPLEEKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPMVPSECNSHSASCSPEWGNALEFGPNPGDHLLAADPTDAHNLHSLTSIVDSITVEDMSVAFPDETMPN
Protein: Uncharacterized protein Rv2599 (P9WL69)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv2598
- Uncharacterized protein Rv2597
- Possible conserved exported protein
- UPF0719 transmembrane protein Rv2600
- N-acetylmuramoyl-L-alanine amidase Rv3717
Sequence:
MSRNRLFLVAGSLAVAAAVSLISGITLLNRDVGSYIASHYRQESRDVNGTRYLCTGSPKQVATTLVKYQTPAARASHTDTEYLRYRNNIVTVGPDGTYPCIIRVENLSAGYNHGAYVFLGPGFTPGSPSGGSGGSPGGPGGSK
Protein: Nuclear transcription factor Y subunit B-10 (AtNF-YB-10) (Q67XJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear transcription factor Y subunit C-2
- Nuclear transcription factor Y subunit C-9
- Nuclear transcription factor Y subunit C-7
- Nuclear transcription factor Y subunit C-1
- Nuclear transcription factor Y subunit C-3
- Nuclear transcription factor Y subunit C-6
- Nuclear transcription factor Y subunit A-6
- Nuclear transcription factor Y subunit C-10
- Nuclear transcription factor Y subunit C-4
- Nuclear transcription factor Y subunit C-8
Sequence:
MAESQTGGGGGGSHESGGDQSPRSLNVREQDRFLPIANISRIMKRGLPLNGKIAKDAKETMQECVSEFISFVTSEASDKCQREKRKTINGDDLLWAMATLGFEDYIDPLKVYLMRYREMEGDTKGSGKGGESSAKRDGQPSQVSQFSQVPQQGSFSQGPYGNSQGSNMMVQMPGTE
Protein: Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) (Q9ES30)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MLGRQRIWWHLLPLLFLPFCLCQDEYMESPQAGGLPPDCSKCCHGDYGFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGVPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYETKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK