wanglab/gogpt-training-data huggingface dataset:
Protein: Putative two component response regulator (A0A0H2ZHG6)
Organism: Pseudomonas aeruginosa (strain UCBPP-PA14)
Interaction partners:
Sequence:
MRPGSIVGIRTQEKPMSKLKIVLADDHPIVRMGVCDMLERDGRFEVVGEASTPSELVEVCRQSEPHIAITDYSMPGDERYGDGLKLIDYLLRNFPRTKVLIFTMVGNRLILDSLYDHGVSGVVLKSGELDELLLALDVVKQNRVYRGANMLDPTSVLANRDEVESRFARLSMKEFEVLRHFVSGSNVCDIARLLKRSVKTVSTQKVSAMRKLEVNSDQALMTFCVHANLFH
Protein: Small ribosomal subunit protein mS38 (28S ribosomal protein S38, mitochondrial) (MRP-S38) (Aurora kinase A-interacting protein) (AURKA-interacting protein) (Q9NWT8)
Organism: Homo sapiens (Human)
Function: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:23908630, ECO:0000269|PubMed:27184847}. Nucleus {ECO:0000269|PubMed:23908630}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein bS21m
- Small ribosomal subunit protein mS34
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS7m
Sequence:
MLLGRLTSQLLRAVPWAGGRPPWPVSGVLGSRVCGPLYSTSPAGPGRAASLPRKGAQLELEEMLVPRKMSVSPLESWLTARCFLPRLDTGTAGTVAPPQSYQCPPSQIGEGAEQGDEGVADAPQIQCKNVLKIRRRKMNHHKYRKLVKKTRFLRRKVQEGRLRRKQIKFEKDLRRIWLKAGLKEAPEGWQTPKIYLRGK
Protein: Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) (O88634)
Organism: Mus musculus (Mouse)
Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prothrombin
- Proteinase-activated receptor 3
- Guanine nucleotide-binding protein subunit alpha-13
- Proteinase-activated receptor 1
- Guanine nucleotide-binding protein G
- Angiotensinogen
- Cathepsin G
Sequence:
MCWPLLYPLVLGLSISLAEGIQTPSIYDDVESTRGSHEGPLGPTVELKEPKSSDKPNPRGYPGKFCANDSDTLELPASSQALLLGWVPTRLVPALYGLVVAVGLPANGLALWVLATRVPRLPSTILLMNLAVADLLLALVLPPRLAYHLRGQRWPFGEAACRVATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGQRLTTGLCLVAWLSAATLALPLTLHRQTFRLAGSDRMLCHDALPLTEQTSHWRPAFICLAVLGCFVPLLAMGLCYGATLRALAANGQRYSHALRLTALVLFSAVASFTPSNVLLVLHYSNPSPEAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSHEFREKVRAMLCRQPEASSSSQASREAGSRGTAICSSTLL
Protein: Cyclin dependent kinase like 5 (A0A096LNR9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMK
Protein: Myosin light chain 12A (A0A8I6AWG5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGELVSVIWRAGPISYQQQQHLGEQSVCLTQDLTATMSSKRAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASMGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEAIGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
Protein: Serine/threonine-protein phosphatase 2A catalytic subunit (PP2A) (EC 3.1.3.16) (G5EGK8)
Organism: Caenorhabditis elegans
Function: Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas-6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation. In association with regulatory subunit rsa-1 and probably paa-1, regulates microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. Plays a negative role in axon guidance probably by dephosphorylating unc-51, unc-14 and vab-8.
Subcellular location: Perikaryon {ECO:0000269|PubMed:20392746}. Cell projection, axon {ECO:0000269|PubMed:20392746}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17218259}. Cytoplasm {ECO:0000269|PubMed:17218259}. Note=Localizes to the margins of VD neuron growth cones and to small transport vesicles (PubMed:20392746). During mitosis, localizes around chromatin after the nuclear envelope breakdown (PubMed:17218259). {ECO:0000269|PubMed:17218259, ECO:0000269|PubMed:20392746}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
- Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4
- Probable serine/threonine-protein phosphatase PP2A regulatory subunit
- Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
- Serine/threonine protein phosphatase 2A regulatory subunit
- Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1
- Leucine carboxyl methyltransferase 1
- Serine/threonine-protein phosphatase 2A activator
- EF-hand domain-containing protein
- Striatin N-terminal domain-containing protein
Sequence:
MAAAPPSADPLDKALIVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Protein: HCG2001997, isoform CRA_c (cDNA FLJ36929 fis, clone BRACE2005231, highly similar to Nicolin-1) (cDNA, FLJ93554, Homo sapiens nicolin 1 (NICN1), mRNA) (B2R7Q3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRVLVPCHVKGSVALQVGDVRTSQGRPGVLVIDVTFPSVAPFELQEITFKNYYTAFLSIRVRQYTSAHTPAKWVTCLRDYCLMPDPHSEEGAQEYVSLFKHQMLCDMARISELRLILRQPSPLWLSFTVEELQIYQQGPKSPSVTFPKWLSHPVPCEQPALLREGLPDPSRVSSEVQQMWALTEMIRASHTSARIGRFDVDGCYDLNLLSYT
Protein: Peroxide stress regulator (Q0PBI7)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Interaction partners:
- 26 kDa antigen
- Glutamate synthase large chain
- DNA-directed RNA polymerase subunit alpha
- Exodeoxyribonuclease 7 large subunit
- Uncharacterized protein
- RNA polymerase sigma factor SigA
- L-glutamate gamma-semialdehyde dehydrogenase
Sequence:
MELLQMLKKHELKATPQRLCVLKILKRHEHPNIDELYIEIKKEYPSISLATVYKNLNTLQEQGLVVEINVLNQKTCYDIYEEEHIHVVCTKCGGIEDLSFKDAKLYEYQEHLEKKIGNLVNHLSVCAYVDNCKKCH
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (Protein 2P1) (Q9JKL4)
Organism: Mus musculus (Mouse)
Function: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular location: Nucleus {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex assembly factor 4
- Complex I intermediate-associated protein 30, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase 1 beta subcomplex subunit 10
- Complex I assembly factor TIMMDC1, mitochondrial
Sequence:
MATALGFRCLFRTRPAPLCRHVDRLWRNPRRGHRLSPADDELYQRTRISLLQSEFPQAVYIDSYSSRGFTICGNRVFGPCVLLPQTVVQWNVGSHQDITEESFSLFWMLEPRIEIVVVGTGNKTERLHPQVLQAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGETALASLGQASE
Protein: Growth factor receptor-bound protein 7 (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) (Q03160)
Organism: Mus musculus (Mouse)
Function: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18273060}. Cell projection {ECO:0000250|UniProtKB:Q14451}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14451}. Cell membrane {ECO:0000250|UniProtKB:Q14451}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14451}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14451}. Cytoplasmic granule {ECO:0000269|PubMed:18273060}. Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions. {ECO:0000269|PubMed:18273060}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-2
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-3
- GTPase KRas
- SHC-transforming protein 1
- GTPase HRas
- Mast/stem cell growth factor receptor Kit
- GTP-binding protein REM 1
- Receptor tyrosine-protein kinase erbB-4
- Platelet-derived growth factor receptor beta
Sequence:
MELDLSPTHLSSSPEDVCPTPATPPETPPPPDNPPPGDVKRSQPLPIPSSRKLREEEFQATSLPSIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDESWGLVESHPYLALERGLEDHEFVVEVQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCLDAQTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLHIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIDNPREALSAAMEEAQAWRKKTNHRLSLPTTCSGSSLSAAIHRTQPWFHGRISREESQRLIGQQGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDEGQTRFTDLLQLVEFHQLNRGILPCLLRHCCARVAL
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (Q3ULQ2)
Organism: Mus musculus (Mouse)
Interaction partners:
- Interferon regulatory factor 3
- Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MADEKLPPGWKKYMSRSSGREYYFNHITNASQWERPSEGSSKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIRKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMEKPFEDASFALRTGEMSGPVFTESGIHIILRTE
Protein: tRNA dimethylallyltransferase (DMATase) (EC 2.5.1.75) (Isopentenyl-diphosphate: tRNA isopentenyltransferase) (IPP transferase) (IPPT) (tRNA isopentenyltransferase) (IPTase) (P07884)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP).
Subcellular location: Note=[MOD+] forms multicytoplasmic aggregates that do not colocalize to either mitochondria or nucleus. {ECO:0000269|PubMed:22517861}.; SUBCELLULAR LOCATION: [Isoform I]: Cytoplasm {ECO:0000269|PubMed:1850093, ECO:0000269|PubMed:8139535}. Mitochondrion {ECO:0000269|PubMed:1850093, ECO:0000269|PubMed:1946403, ECO:0000269|PubMed:8139535}.; SUBCELLULAR LOCATION: [Isoform II]: Cytoplasm {ECO:0000269|PubMed:1850093, ECO:0000269|PubMed:1946403, ECO:0000269|PubMed:8139535}. Nucleus {ECO:0000269|PubMed:8139535}.
Interaction partners:
- tRNA
- tRNA
- Threonylcarbamoyl-AMP synthase
- Eukaryotic peptide chain release factor GTP-binding subunit
- Multisubstrate pseudouridine synthase 7
- [PIN+] prion protein RNQ1
- tRNA-dihydrouridine
- tRNA
- tRNA
- tRNA pseudouridine
Sequence:
MLKGPLKGCLNMSKKVIVIAGTTGVGKSQLSIQLAQKFNGEVINSDSMQVYKDIPIITNKHPLQEREGIPHHVMNHVDWSEEYYSHRFETECMNAIEDIHRRGKIPIVVGGTHYYLQTLFNKRVDTKSSERKLTRKQLDILESTDPDVIYNTLVKCDPDIATKYHPNDYRRVQRMLEIYYKTGKKPSETFNEQKITLKFDTLFLWLYSKPEPLFQRLDDRVDDMLERGALQEIKQLYEYYSQNKFTPEQCENGVWQVIGFKEFLPWLTGKTDDNTVKLEDCIERMKTRTRQYAKRQVKWIKKMLIPDIKGDIYLLDATDLSQWDTNASQRAIAISNDFISNRPIKQERAPKALEELLSKGETTMKKLDDWTHYTCNVCRNADGKNVVAIGEKYWKIHLGSRRHKSNLKRNTRQADFEKWKINKKETVE
Protein: Capsid assembly scaffolding protein (SP) (Gp46 protein) (A4ZFB2)
Organism: Staphylococcus phage 80alpha
Subcellular location: Note=Found in provirions but not in mature virions. {ECO:0000269|PubMed:17693489, ECO:0000269|PubMed:18565341, ECO:0000269|PubMed:28984245}.
Interaction partners:
Sequence:
MEENKLKFNLQFFADQSDDPDEPGGDGKKGNPDKKENDEGTEITFTPEQQKKVDEILERRVAHEKKKADEYAKEKAAEAAKEAAKLAKMNKDQKDEYEREQMEKELEQLRSEKQLNEMRSEARKMLSEAEVDSSDEVVNLVVTDTAEQTKSNVEAFSNAVKKAVNEAVKVNARQSPLTGGDSFNHSTKNKPQNLAEIARQKRIIKN
Protein: Casein kinase I homolog 1 (EC 2.7.11.1) (P23291)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10866691}; Lipid-anchor {ECO:0000269|PubMed:10866691}. Mitochondrion membrane {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Casein kinase I homolog 2
- Pheromone alpha factor receptor
- Pheromone a factor receptor
- Palmitoyltransferase AKR1
- Protein STD1
- High glucose sensor RGT2
- Heterogeneous nuclear rnp K-like protein 2
- Low glucose sensor SNF3
- Serine/threonine-protein kinase RIM11/MSD1
- Glucose transport transcription regulator RGT1
Sequence:
MSMPIASTTLAVNNLTNINGNANFNVQANKQLHHQAVDSPARSSMTATTAANSNSNSSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDLGETADGQYDWMKLNDGRGWDLNINKKPNLHGYGHPNPPNEKSRKHRNKQLQMQQLQMQQLQQQQQQQQYAQKTEADMRNSQYKPKLDPTSYEAYQHQTQQKYLQEQQKRQQQQKLQEQQLQEQQLQQQQQQQQQLRATGQPPSQPQAQTQSQQFGARYQPQQQPSAALRTPEQHPNDDNSSLAASHKGFFQKLGCC
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (K1J238)
Organism: Aeromonas dhakensis
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00318}. Secreted {ECO:0000256|HAMAP-Rule:MF_00318}. Cell surface {ECO:0000256|HAMAP-Rule:MF_00318}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. {ECO:0000256|HAMAP-Rule:MF_00318}.
Interaction partners:
Sequence:
MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKALEAVNGPIAQALLGKDAKDQATVDQIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYAHIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYKLGTDVTLAMDCAASEFYDAEKKEYNLKGEGRVFTSNGFSDFLEELTAKFPIVSIEDGLDESDWEGFAYQTQKLGKKIQIVGDDLFVTNTKILKRGIDNGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGAKAPFRGLKEVKNQA
Protein: Nan1p (Q5AFB9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- KRR1 small subunit processome component
- Utp18p
- U3 small nucleolar ribonucleoprotein protein MPP10
- Utp8p
- GTPase
- Utp4p
- SnoRNA-binding rRNA-processing protein
- rRNA 2'-O-methyltransferase fibrillarin
- SnoRNA-binding rRNA-processing protein
- SnoRNA-binding rRNA-processing protein
Sequence:
MPSAISEWSLSMATGGKPLYLPCSQTTASVYSQDGRYVIIALTHQLRVYFISTRQCIKTIDLDLHDLADLKIDVTNGNQVLLFKTSGEILTVNWKDKVSQPIISTIDINKTQSGTSLPLLSVISVKHLFFIIVTGRKEKKKGTPHTRYINYFDRNSESLVPIIEVANSINFATSLDNTKIAFITSGNEIDLFDLSGIFNVDSIENLSDNDIVKETIPFVYRSPVTSIAVSNDSMIAIGTSAGPIQIVYGGLTTPKPQRVLKWHLDQVKGLMFTADNNYLLSGGMEKVLVFWQLETEKKQFLPRLNGVIDKISIDNYKNDYISLQLNVDPLDNNYEILVLSAVDLVSRLSVNTVRPKFAYNIATTLSKTKKKFIKSSSDFDKFKIRYDYTSQFEIHPKTKSMYFPNGALIQSFDLFKNEQNFIQHGAPVLGVGKVRSETKLLDPLVTLLKFTHDGEWMCTFDEFTNTEVDSLLLKNEKQYALKFWKYVGHKENATSGINNNNKTGHWELTTKIIDPHGMNPILAMIPAPTSYFNGLAFLTADDKGGLRIWRPSVPKEQYKTTSARSQQTAWTLRKSRAPSALSSDAVALSWSDDNSLIFLAHECSILTIDSKSFEEIPDFKIPSLSGSRVRSLNMVNNNLIVLSKTRISSFDLITGELTSLVAKVNTTIGAKNLIAIDPIKRLICLALNYYSEENNTLSIKSKILIFKPNQLKPICVQLHEQGVSSIRYFNSSFVFVDLDCRVGTIYSNEEITETIELGLTQEINNMLIAAQATADVINDRNVKTTVGHQNGNKEGEMDIDNSMAYAAKVVDLHTFQPIFQNIEGVQVESLFERIVNVLK
Protein: Transcription factor IIIA (TFIIIA) (Q8VHT8)
Organism: Rattus norvegicus (Rat)
Function: Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- TATA box binding protein
- General transcription factor 3C polypeptide 1
- B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
- General transcription factor 3C polypeptide 5
Sequence:
MEPRVSVAEAVSSLTIADAFVRACVGPAPPRPALPSRFICSFPDCSASYNKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHILIHTGEKPFVCADNGCNQKFSTKSNLKKHIERKHENPQKQYVCNFEGCKKAFKKHQQLRTHQCQHTNEPLFRCTHEGCGKHFASPSRLKRHGKVHEGYLCQKGCSFVGKTWTELLKHTREAHKEEVTCTVCQKMFKRKDHLKQHMKTHAPERDVYRCPREGCARTYTTVFNLQSHILSFHEEKRPFVCEHAGCGKTFAMKQSLMRHSVVHDPDKKRMKLKVRPPRERRSLASRLSGYVPPKGKQEPDCSLPNSTESSSSPEATMLAPAALLTVH
Protein: Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) (Q14957)
Organism: Homo sapiens (Human)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:26875626}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 3A
- Glutamate receptor ionotropic, NMDA 3B
- Disks large homolog 4
- Proenkephalin-B
- P2X purinoceptor 6
- Nitric oxide synthase 1
Sequence:
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV
Protein: Zcf18p (A0A1D8PPQ3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Zcf13p
- CBM21 domain-containing protein
- Zcf22p
Sequence:
MSVPLTKEKKKRSRGGCVSCKKLKIKCNEQKPICEYCRYTKRTCIYPILAPIKGYRRKTSRSPQESKDEKTSTPHSSTTAISPISSSSTSDKLNNLYVSNNEVPDINPYHYDKLSRDLVLTNSTSMLGITRFELRLLQFFDQECINFFSFGVNKNIHNTWKYKVPYLFLESELVRKSMFALSAMGLSTTLDLDELQSIDADEDEKSLVNIYNTNVDELDNIFENTTKYFMDTISKTKHMIGSIEDDSNIASFDDPKSAKELLVSSILVFSYLGVHPHRLSPLIDFTQERGDLIQISKGIRYTIMSCAPTILKSDMSPLLFFHGIEKMQTPTFEKCQYPIIQDLKNDIDEFGSGEGSSEISEELSILKDVVARLMMCINGCKFFKFPIPLFRFLMLFDDHFRDLLYNKHRLALRILYVYSALCSICRFQFFDERNVWKDYMTWYRGYAAENFDGYKNETDEYLYFLAAIEHFHWDDFTNFDKFNPKAEFEKVIQSGKYRKQSLLVGQNSNC
Protein: LD37218p (Q86PB0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKATIDKELLPMKAHYFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFVPGMEKPLPKVEFHCHQGVSDIPRFCSEYGECVERNLERYYGNRTLECELNCEAQPFMWDIVCEDWLKNNTENCAANRTNTQMEFGASITMQKIENDGSCMFFMIPHDQGQIAGQNVTLYCPKEKEYFKSNCTMDCREDYLKEQLAESAVINTSSAVTMPQFWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHHLYGKQRLCGSLGWGVFALLAGLLVDHMSLGEVNKNYTAVFWMALLIMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELDKAFEGCDSSIKTLEGLVMGIQCFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFEGVGVSMGNLIAGQLFESVTARTTFEIFGIGAFIVFVIHVCIQLYLQRNSNIDENGTVKYFAPTDAMHMLNDQEYSRVS
Protein: Poly(A) polymerase (EC 2.7.7.19) (Q57WJ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR018425}.
Interaction partners:
- Cleavage and polyadenylation specificity factor subunit 2
- C3H1-type domain-containing protein
- Cleavage and polyadenylation specificity factor 30 kDa subunit
- Cleavage and polyadenylation specificity factor subunit, putative
- Cleavage and polyadenylation specificity factor-like protein, putative
- Uncharacterized protein
- polynucleotide adenylyltransferase
- Suppressor of forked domain-containing protein
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
- Nucleic acid binding protein, putative
Sequence:
MSRTDKSFLAKKIISSDGPSPAEEDHNVPLVEWCAAGIEPEEEANRRRSVLEHINCIVRAWIRSTMIAEFRMPAEAAAQVEGRIFATGSYRYNVHGSGSDIDIVLIAPNRITREHFFNTLAPRLSHESRITELHCIRDARVPLIAMVADGIDIDLSFGSIRQDRVPEVITDDLLQGLDDQSVLSCNAVRVAHNIMDLVPHKASFRQALRFIKAWGKARGIYSNTFGFPSGIGWAILVAFVCQCHPNQNAAGMVVRFFRIYHTWFSPNPHGSGRENRAIYLTETMRVKTNLGRGWDPRESKSDALALFPVLTPAVPYGNACYNVTMTNLRQLCDEFARGHEICSSYIGMGVEETKMKLGPHGIWSKILEPVKFFGEYKYYLHVQVTCTDAEAYQGYVDAVESKIRFLWAGTAESRAQSLESFPHVRLRLNPKGYEAPEEVEARSRLLKKAPRGGGIPESGAQGRAGASSNGNSSSVSSAVGGGSAGTAVKSFSRHYYFGMSVDSKAASMKVDLAPSIRSFHNIVRQLRQYRDGVTRLPVITVEDMTKIPAFVKAAAGYKDPVSTTESDAGSGRACTPSEADTATSSNGAAAATAGASEAADKSEGAPSAETAGVKRHRGEDDENDAAAMKVVAKDSVNSAIADHAGPKLGKGSAEGGGARRDNSTGHSKVSQDDDEELGLEQALGLGF