wanglab/gogpt-training-data huggingface dataset:
Protein: ABC transporter F family member 4 (Q8T6B4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL23
- eIF-2-alpha kinase activator GCN1
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL30
Sequence:
MGPKGKKKGQSFDDSDEEINNKKGGNKKGQQLEDDIPQPVKKGGNKKGQRGKQDSDDEPENIPQPVAKKSNNKKGQRGKQDSDDEQDEIPQPQKKGGKPAPQPQKKGGKQQDSDDEQDEIPQPVKKGGKPAPQKKGGKQQQQQDSDDEQEEIPQPVKKGGKPAPQKKGGKQQDSDDEEDEIPQPVKKGGKPAPQKKGGKQQESEDEDEEDEVQQPVKKGGKNDKKKGVKHVEEEEEEEEEEEIEQPVKKGGKAPKPKKGGKGSKQESEDEEDDVQQPVKKGGKKDKKKGSKHVEEEEEEEEEEEIEQPVKKGSNKKDQKKGGKGKHVEEEEEEEEEEEIEQPVKKGSNKKDQKKGGKGKQQQESEDEEEEIQQPVKKGGKKDKKKGSKHVEEEEEEEEEEEEIEQPVKKGGKKDKKSSLEDSMSELSIKSKKGGKGKHVEEEEEQEQEEEEEKPKSKSNKKDKKKGKHVEEEEEEEEEEEEKPKSKSNKKDKKKGSKHIEEEEEEEEEEEEEEKEEEEEKKMTLAEIRAAKKVKKVDKKEKKKEKEKKKRDEQEEDAFELAKKKQQEEIDYDNIDIDDVPGKDAPTYVHLKSSEGLRSKIGNDIKFDNLILSVPGRILLNNASLTLAYGQKYGFVGRNGIGKSTLVKKIAMRDEITIAPHLRVLYVEQEVTGDDTTPLDCVLAADEERKWLLDEEKVLTELEKVNPSWQFDPRQKRNYSLRDIYDRLKEIDADKASIRAANILIGLGFTFEEISVKKSRDYSGGWRMRIALARALFCKPEVLLLDEPSNHLDLHACVWLEKYLNQWDRTLLVVSHEASFLNEVVDNIIYIHDQKLDQYRGNYDAFMKQKSVNLRSKEKEKDKQDRKLKKMNEFITKNKNNTQAKQAASRAKKMEKIETIELEREDASLVVDFPQPEHLTPPLLVFKDVCFGYEGRPTMFKKLDIGIDMDSKIALVGMNGVGKSTLMKLMNGDLHETTGYIERSRKMRVARFSQHFVDQLDTTMTPIEYFQSKFNNPPVQQIRNHLGRFGICNSLPLHKITTLSGGQKSRVILAELAWAEPHILLLDEPTNHLDIDAIEALAEGINAFTGGVVLISHNQHLINLIAEQIWVVKKDGTIYLYPGTFMDYKNEISREIDNMVIRS
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) (P0AB91)
Organism: Escherichia coli (strain K12)
Function: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Interaction partners:
- 3-dehydroquinate synthase
- Bifunctional chorismate mutase/prephenate dehydratase
- T-protein
- Shikimate kinase 2
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
- Transketolase 1
- HTH-type transcriptional regulatory protein TyrR
- Phosphoenolpyruvate synthase
- Shikimate dehydrogenase
Sequence:
MNYQNDDLRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVVIGPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQINDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASGLSCPVGFKNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKEPNYSAKHVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESHLVEGNQSLESGEPLAYGKSITDACIGWEDTDALLRQLANAVKARRG
Protein: Protein YIP4 (YPT-interacting protein 4) (Q9P6P8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in proper membrane localization of Rab GTPases.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein YIP5
- Golgi apparatus membrane protein tvp23
Sequence:
MTDIGKHNTEIEQDEMENLLRMDPVRSSLDVESRAIEPDNIAGESIVETRFTGGDSLDEPIRVTLFNEFRAIGEKLVYVLYPKNAQVLRDWDLWGPLIFSLVIALALALSTDKIERESVFTVVVALIWFGEAVCSLNIKLLGANISIFQSMCILGYSSFPLMIASIVCAFVPLIFIRIPVIVAMYAWTLFAAMGVLQNSNLSNKKLLAVYPLFLFYFSLAWIIFL
Protein: Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1) (Q6YN16)
Organism: Homo sapiens (Human)
Function: Has apparently no steroid dehydrogenase activity.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19703561}. Mitochondrion {ECO:0000269|PubMed:38820148}.
Interaction partners:
- Enoyl-CoA delta isomerase 2
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- 3-ketoacyl-CoA thiolase, peroxisomal
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Lambda-crystallin homolog
- Alpha-methylacyl-CoA racemase
- Acetyl-CoA acetyltransferase, cytosolic
- Cocaine- and amphetamine-regulated transcript protein
Sequence:
MLPNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVKATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNARL
Protein: RING finger protein 39 (EC 2.3.2.27) (Protein HZFw) (Q9H2S5)
Organism: Homo sapiens (Human)
Function: May play a role in prolonged long term-potentiation (LTP) maintenance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:33674311}.
Interaction partners:
- HLA class I histocompatibility antigen, alpha chain F
- DNA-directed RNA polymerase I subunit RPA12
Sequence:
MWWRDLTRLRLWLKREAIPGEGRKAAKVNAGVGEKGIYTASSRGGPPSARSKAVTVVAEGAASRSWLSMDAPELGPGLVERLEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGTPPATGTEASPTACPCCGLPCPRRSLRSNVRLAVEVRISRELREKLAEPGARAGRRRGGRIPTMGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRRLLISADRRSVQLAPPGTPAPPDGPKRFDQLPAVLGAQGFGAGRHCWEVETADAASCRDSSGEDADDEESHYAVGAAGESVQRKGCVRLCPAGAVWAVEGRGGRLWALTAPEPTLLGGVEPPPRRIRVDLDWERGRVAFYDGRSLDLLYAFQAPGPLGERIFPLFCTCDPRAPLRIVPAES
Protein: Tapetum-specific methyltransferase 1 (AtTSM1) (EC 2.1.1.-) (Trans-caffeoyl-CoA 3-O-methyltransferase) (CCoAMT) (CCoAOMT) (Q9C9W4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methyltransferase involved in phenylpropanoid polyamine conjugate biosynthesis. In vivo, methylates only one of the 5-hydroxyferuloyl moieties of N1,N5,N10-tri-(hydroxyferuloyl)-spermidine, while is able in vitro to convert all three 5-hydroxyferuloyl residues to the corresponding sinapoyl moieties and to methylate caffeoyl CoA and tricaffeoyl spermidine.
Interaction partners:
- Cytochrome P450 98A8
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- Trans-cinnamate 4-monooxygenase
- Cytochrome P450 84A1
- Shikimate O-hydroxycinnamoyltransferase
- Cytochrome P450 98A9
- Phenylalanine ammonia-lyase 1
- Phenylalanine ammonia-lyase 4
- Phenylalanine ammonia-lyase 2
Sequence:
MDGRLPDKGILKSEALKQYIMETTAYPREHELLKELREATIQRYGNLSEMGVPVDESLFLSMLVKIINAKNTIEIGVFTGYSLFTVALALPEDGRITAIDIDQAGYNLGLEFMKKAGVDHKINFIQSDAVRGLDQLLNGEKQEYDFAFVDADKTNYVYFLEKLLKLVKVGGIIAFDNTLWFGTLIQKENEVPGHMRAYREALLEFNKILARDPRVEIAQISIGDGLTLCRRLI
Protein: AGAMOUS-like 83 (Similarity to MADS-box protein) (Q9FGZ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Agamous-like MADS-box protein AGL53
- AGAMOUS-like 48
- Agamous-like MADS-box protein AGL49
- Agamous-like MADS-box protein AGL90
- AGAMOUS-like 102
- AGAMOUS-like-34
- Zinc finger protein CONSTANS-LIKE 1
- Auxin-responsive protein IAA4
- Transcription factor MYB60
- At5g26880
Sequence:
MRFVPYLYEIERLWLSLVNYLSPRKNKNRRCGEIDKIRMVKKGGTKRKIAIETIQKSDYLRVTCTKRREGLFSKASQLCLLSDAQIAILATPPTSESNISFYSFGHSSVDAVVSSFLSGQRCVPLQEDTKEMREDVAICLSRTNLGLGFWWNNESLNKSENPQEISDAINSMLTLLSNLKELSGEEALVNDHKDLKKNERSDVVLQHGTQYETLNPNSNTTTICCVPDELPANSNEIVGISPNPLIMLEKKKSQIEEKFEKEWQVSVTRIENEATSSYAKRRRSI
Protein: Dysfusion, isoform C (A8JRD5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPNAIGASSITKWISQIESFEQRELVTNICKRAIDDMYADNKRGLDKVTAATPPTHALQQQQQQQHPHQQQQHLQHVLQLQQQQQQHLQQQQHHLQHQMHTHHNFQQHETSPTVSQQQHMQQQQPQTTQQQHATQQQQQQQQQTAGMFTRFDANKSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMHHLHHQTATPNIGFSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYDIIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSLEGEHRMFLCRMNVSRNARRQMRFGDQKVVLVQGHYLSFLPLCSRNEPVFLATCTPIAMPETRECVVQGATNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNLTEAQKKHSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREASIMLANSWLYHYYTVQSKIQFGMPLDSGIRVPPGTPSSGYYSPHSSHPPATPGGATPNLGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHAKAAIELKEDQPLFCFQEPVDYSQVNSHVNPPNATSTPNPPISKSSTPPPPKKRARKLEPLYLHAERSPAAAITPEPDCYAIHTHPAAAYATSSVVSSDASVIYATIVPTRPRLPNKSLPPDPADFIEQWNPSPPWSESAQKASLDSFGSSHELSPCITTTPPTPTSATPHQSGLGTTQTIGPAFSFEWMSDPLVPVTYQQWPPTGDHHQHLSQHLSQSQNHQNPLQQQQNEQLLLGQQPHLHQQHQHLALHHGRGEHSLEGESQGVVVVPPIPISIPIPTATGHGDAGEPVEDRG
Protein: Apoptosis regulator Bcl-2a (B-cell leukemia/lymphoma 2) (Bcl2) (Q564A4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- BCL2-like 11
- Beclin-1
- Caspase 3, apoptosis-related cysteine peptidase a
- Caspase 3, apoptosis-related cysteine peptidase b
- Cellular tumor antigen p53
- BCL2-interacting protein 3.
- BCL2 associated agonist of cell death b isoform 1
- Caspase-9
- Cytochrome c
- Apoptosis regulator BAX-like
Sequence:
MANEISYDNRNIVEKYLKHKLSKRGYVWKCQSSAEEDDTFNKAVEESSPNSDRRLQAPSAGGGNNSECLIARVTRSDPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVFNPNSAQRSFLTVAEELFRDGVNWGRIIAFFEFGGTMCVESVNREMASQVDNIAHWMTDYLNGPLENWIEENGGWDAFVEMYGQQRDSVFHPFSYLTKVLGLAALGLAGVTIGAFFAQK
Protein: Probable receptor-like protein kinase At2g21480 (EC 2.7.11.-) (Q9SJT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Pollen-specific leucine-rich repeat extensin-like protein 4
- Protein RALF-like 19
- GPI-anchored protein LLG3
- Protein RALF-like 4
- GPI-anchored protein LLG2
- Probable disease resistance protein At4g19530
- Disease resistance protein RPS4B
- Cyclase-associated protein 1
- Cytochrome P450 76C3
- GPI-anchored protein LLG1
Sequence:
MEIRKKPNIPMCLVLDSSSRPFMTLLFTILLFLTGLASAVGAVGGSPTAGFKPADDILIDCGSKSSTKTPEGRVFKSDSETVQYIEAKDDIQVSAPPSDKLPSPIYLTAKIFREEAIYKFHLTRPGWHWVRLHFFAFPNDKFDLQQATFSVLTEKYVLLHNFKLSNDNNDSQATVQKEYLLNMTDAQFALRFKPMKGSAAFINGIELVSAPDELISDAGTSLFPVNGFSGLSDYAYQSVYRVNVGGPLITPQNDTLGRTWTPDKEYLKDENLAKDVKTNPTAIIYPPGVTPLIAPQTVYATGAEMADSQTIDPNFNVTWNFPSNPSFHYFIRLHFCDIISKSLNDLYFNVYINGKTAISGLDLSTVAGDLSAPYYKDIVVNSTLMTSELQVQIGPMGEDTGKKNAILNGVEVLKMSNSVNSLDGEFGVDGQRASMGKQGMVATAGFVMMFGAFVGLGAMVYKWKKRPQDWQKRNSFSSWLLPIHAGDSTFMTSKTGSHKSNLYNSALGLGRYFSLSELQEVTKNFDASEIIGVGGFGNVYIGTIDDGTQVAIKRGNPQSEQGITEFHTEIQMLSKLRHRHLVSLIGYCDENAEMILVYEYMSNGPFRDHLYGKNLSPLTWKQRLEICIGAARGLHYLHTGTAQGIIHRDVKSTNILLDEALVAKVADFGLSKDVAFGQNHVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVLLEALCARPAINPQLPREQVNLAEWAMLWKQKGLLEKIIDPHLVGAVNPESMKKFAEAAEKCLADYGVDRPTMGDVLWNLEYALQLQEAFSQGKAEAEEVETPKPVAVPAAAPTSPAATTAAASERPVSQTEEKDDSTVDQHSGTTMFTQFASLNGR
Protein: Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (F1RDD0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSVGFIGAGQLAHAMVKGFTAAGVIAANRITASSPDTELPTVSGLRKMGVNLTTSNKEATHRSDVLFLAVKPHIIPFVLDEIGPDIEDRHLIVSCAAGVTISSIEKKLLQYRESPKVMRCMTNTPVVVREGATVYATGTHAHLEDGKLLEQLMASVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALMGAAKMLLDSEQHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSLADQEQISAAAIKKTTLDKVLQQPGVTHNSVGTRSRVNLFNNRSKKS
Protein: Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) (Q3V3I2)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Taste receptor type 1 member 3
- Guanine nucleotide-binding protein G
- Taste receptor type 1 member 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Taste receptor type 1 member 1
- Guanine nucleotide-binding protein G
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel subfamily M member 5
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Sequence:
MGSGISSESKESARRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSKQECMEFKAVIYSNTLQSILAIVKAMATLGIDYVNPRSREDQEQLHSMANTLEDGDMTPQLAEIIKRLWGDPGIQACFERASEYQLNDSAAYYLNDLDRLTAPGYVPNEQDVLHSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQEKVAKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
Protein: Acetylcholinesterase (AChE) (EC 3.1.1.7) (P36196)
Organism: Gallus gallus (Chicken)
Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Subcellular location: Synapse. Secreted. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Acetylcholine receptor subunit delta
- Collagen like tail subunit of asymmetric acetylcholinesterase.
- MFS domain-containing protein.
- Muscle, skeletal receptor tyrosine protein kinase
- Uncharacterized protein.
- Agrin
Sequence:
MAPLFLLLLLLLSPSPTSAHRFAYSAPNRPEVRTTTGSVRGLLIPAGPSGSTAAAFLGIPFAVPPLGPLRFRPPLPIPTPWTGIRDADSQPFACYQMVDTTFPGFQGSEMWNPNREMSEDCLYLNVWTQKGDPTEPPVLVWIYGGGFTGGSVSLDVYDGRYLAAAEEAVVVSMNYRVGSLGFLALAGHRDAPGNVGLWDQRLALQWVRDNAEAFGGDPDLITLFGESAGAASVGFHLLSPHSKGLFRRAVLQSGSPNGPWATIGAAEGRRRAAALGRAVGCPYGNETEFLGCLRGKEAADVLEGEGVVMPPQSVFRFAFVPVVDGDFVVDSPDVALWGDYGVKGGEGGHGVEGGDGGYGVKGGDGVKGGYGGGYGARGVREGDGDGGYGVKEGLREGYGVKEGYGVEGDGANAYGARVPPRPHRDETPPDAYGAKGSADAYGAKAAPRPHRDETSPDAYGAKMPPRPHRDEASPDTYGAKMPPRPHRDETSPDAYGAKMPPRPHRAGGEVEVLLGAVRVEGSYFLVYGVPGFGKDNESLISREEFLGGVRMGVPQATELAAEAVVLHYTDWLDADNPVKNREALDDIVGDHNVVCPLMAFAQRWAQRGGKVYAYLFDHRSSTLLWPSWMGVPHGYEIEFVFGLPLEPRNNYTREEVELSRRIMRYWGNFARTGDPNGGVGGPRWPPYTPSGQRYAHLNARPLSVGHGLRTQICAFWTRFLPKLLNATGPPEDAEREWRLEFHRWSSYMGRWRTQFEHYSRQQPCATL
Protein: Zinc finger CCCH domain-containing protein 63 (AtC3H63) (Zinc finger CCCH domain and WD40 repeat-containing protein 2) (Q9FNZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING-box protein 1b
- RING-box protein 1a
- Glucose-methanol-choline
- At1g12570
- Transcription factor bHLH118
- Transcription factor bHLH120
- Zinc finger CCCH domain-containing protein 15
- Transcription factor bHLH36
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
Sequence:
MDFDLNGGNKRVFNRLGGGGGSTRPMAPTDTRQKVCFHWRAGRCNRSPCPYLHRELPGPGPGQGQGPGYTNKRVAEESGFAGPSHRRGPGFNGNSSSSWGRFGGNRTVTKTEKVCNFWVDGNCTYGDKCRYLHCWSKGESFALLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKLGGEIGCVLSEGPWLLVGMPNLVKAWNIETNADQSLSGPVGQVYSLVVGTDLLFAGTQDGSILAWRYNAATNCFEPSASLTGHTLAVVTLYVGANRLYSGSMDKTIKVWSLDNLQCIQTLTDHSSVVMSLICWDQFLLSCSLDNTVKIWAAIEGGNLEVTYTHKEEHGVLALCGVHDAEAKPVLLCACNDNTLRLYDLPSLGLFIRFTERGKIFAKQEIRAIQIGPGGIFFTGDGTGQVKVWKWCTEPTAALP
Protein: Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) (P83268)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming.
Subcellular location: Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q6ZWX6}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56286}. Mitochondrion {ECO:0000250|UniProtKB:P05198}. Note=Colocalizes with NANOS3 in the stress granules (By similarity). Relocalizes to the surface of mitochondria in response to mitochondrial damage and phosphorylation by EIF2AK1/HRI (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000250|UniProtKB:Q6ZWX6}.
Interaction partners:
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit 3
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 3 subunit A
- Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Eukaryotic translation initiation factor 3 subunit B
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 3 subunit C
Sequence:
PGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGRILLSELSR
Protein: Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) (Q8TAG9)
Organism: Homo sapiens (Human)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O54923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54923}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54923}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250|UniProtKB:O54923, ECO:0000269|PubMed:16213214}.
Interaction partners:
- Exocyst complex component 5
- Exocyst complex component 8
- Exocyst complex component 3
- Exocyst complex component 1
- Exocyst complex component 4
- Exocyst complex component 7
- Ras-related protein Rab-11A
- Exocyst complex component 2
- Ras-related protein Rab-8A
- Ras-related protein Rab-10
Sequence:
MAENSESLGTVPEHERILQEIESTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVHTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSAKRYYSALKTMEQLENVYFPWVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQHQKTFSVSLQKQNKMKFGKNMYINRDRIPEERNETVLKHSLEEEDENEEEILTVQDLVDFSPVYRCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLTVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPVVNEEEYKIVISKFPFQDPDLEKQSFPKKFPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIRKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHM
Protein: Ankyrin 2 (A0A5F9ZHY6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKDNNE
Protein: Uncharacterized protein (Q582F5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYTTTDLIQTRVAPAHLFVIVYFLQWLFVASTASGESVHAIFKISKSGDAPFFKQAERHCERAKMRLATPTTAKGATAVKKLLKRCGPSDVPVLGGGLSVRCSSNSFFFLWSPKLDEPKYPVEDTAPYCGERDPRGWGTKCVTRNRSAGRLFYQFHTSEGEKGNCTGPVTMDYDPAILYELEVPSAGEEGLLAWVVSRGGKNGSTAALRSLRSDLEDTSRAYIGDSSKMIEYVLCEGGRSSVVSSTSCYSVSYASVPNVGGSSRTGVHWLVIVFLSFIGLIVLCVVTLSIVGGVTKKVTAGNVDRGDNTGSGRRRTSLSHSSWHVMSQPGGSSGIQYSRRGSQPGNILSPLQDAASINMQRYESDGVAAVPRQGSFNGRNTQQRSSLPTNVNQAQQNYNTNRVTSQVSNYSASLHRLGSFRGPIIHRQGSFNNITSVPAGNTYTGGLSRPGSFRGSSPNHQGSFNRSDIFRDPSLYGESPPHGDPRLGLNPLRDIGYDRGNAPEQVSLSSVGMAQQGNFANVGARGGSFRGINRNQQGSFRNSNPPSGGLFNT
Protein: Odontogenic ameloblast-associated protein (Apin) (D6RA81)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKIIILLGFLGATLSAPLLLNLNNGQLLPLQLQGPLNSWIPPFSGILQQQQQAQIPGLSQFSLSALDQFAGLLPNQIPLTGEASFAQGAQAGQVDPLQLQTPPQTQPGPSHVMPYVFSFKMPQEQGQMFQYYPVYMVLPWEQPQQTVPRSPQQTRQQQYEEQIPFYAQFGYIPQLAEPAISGGQQQLAFDPQLGTAPEIAVMSTGEEIPYLQKEAINFRHDSAGVFMPSTSPKPSTTNVFTSAVDQTITPELP