wanglab/gogpt-training-data huggingface dataset:
Protein: Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Q8VZ08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Neutral ceramidase 3
- Neutral ceramidase 2
- Neutral ceramidase 1
- Ceramide kinase
- beta-galactosidase
- Sphingolipid delta
- Beta-galactosidase 2
- Beta-galactosidase 17
- AP-2 complex subunit sigma
- AP3-complex subunit beta-A
Sequence:
MVGATLFHRRKHSWPTEEFISRSTLQLLDFDSAAPPPHAWRRRLNCHANILKEFTITFREAIKMVRLGIRLWSYVREEASHGRKAPIDPFTKENCKPSASQGVPLGGMGSGSISRGFRGEFKQWQITPGTCDPSPMMSNQFSIFISRDGGHKKYASVLSPGQHGSLGKSRDKGLSSWGWNLNGQHSTYHALFPRAWTIYDGEPDPELKISCRQISPFIPNNYRDSSLPAAVFVYTLVNTGKERAKVSLLFTWANSMGGTSHMSGGHVNEPFIGEDGVSGVLLHHKTGKGNPPVTFAIAASETQNVNVTVLPCFGLSEDSSFTAKDMWDTMEQDGKFDQENFNSGPSTPSLAGDTICAAVSASAWVEAHGKCTVSFALSWSSPKVKFSKGSTYDRRYTKFYGTSPRAALDLVHDALTNYKRWEEDIEAWQNPILRDERLPEWYKFTLFNELYFLVAGGTVWIDSSSLNANGNSQHQQSGLGNSDGKVGGLDINDQRNDLGNGNSVGVKSNDEVSAIHNRNGLFVDTPHVDDGDDVGRFLYLEGVEYVMWCTYDVHFYASYALLMLFPKIELNIQRDFAKAVLSEDGRKVKFLAEGNVGIRKVRGAVPHDLGMHDPWNEMNAYNIHDTSRWKDLNPKFVLQVYRDFAATGDYQFGIDVWPAVRAAMEYMEQFDRDNDDLIENDGFPDQTYDTWTVHGVSAYCGCLWLAALQAAAAMALQIGDKFFAELCKNKFLNAKAALETKLWNGSYFNYDSGSSSNSKSIQTDQLAGQWYAASSGLPPLFEESKIRSTMQKIFDFNVMKTKGGKMGAVNGMHPDGKVDDTCMQSREIWTGVTYAAAATMILSGMEEQGFTTAEGIFTAGWSEEGFGYWFQTPEGWTMDGHYRSLIYMRPLAIWGMQWALSLPKAILDAPQINMMDRVHLSPRSRRFSNNFKVVKHKAKCFGNSALSCSC
Protein: Nuclear envelope protein ndc1 (Cell untimely torn protein 11) (O13961)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope.
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Central core structure of the nuclear pore complex.
Interaction partners:
- Nucleoporin pom152
- Nucleoporin alm1
- Tubulin alpha-2 chain
- Spindle pole body-associated protein sad1
- Meiotically up-regulated gene 87 protein
- Nucleoporin nup184
- Nucleus export protein brr6
- Meiotically up-regulated gene 31 protein
- Nucleoporin nup189
- Spindle pole body protein pcp1
Sequence:
MVMLRTSFPSGSRTKAVRYHTLLRPILQQRFLRACFALLCLCCITSYWFSSGPFISLSFWFLSLVRGFVCFFFMFPYFVMLKSRMSTQKVTKQSLGAQLFYDFSPKSFFLVYLTFAVSVSCLCLFYIKGHASSIRLQWIASPNAYELPSLNERFVYMTYFSHILILALTVEHLYLQRDSPSRPVINVSFFNYIFQNLGWLIRFSFRKSIICCLFTPFSYAILRSYIWRFAALLTSCCRRIAYTKTPPKWPLSLRLLLHSFWMAFIVCLTFQIALLIFRVFLYSGPMIRGKLLSARSNDPNGTLVDGMKTKKKPLTECIATEELWFIAKRDPQRIKSIFQDIDRSVSIWQELYSITESRCKELATSLKILQSTGDFSAATSKKSGLTKKTNIPYSPNSNHEEINSIPLRNKNIFVPPSQGHSPLLEKIKKQGSLPSTTPVNEGGISDIIPKSLYDQVIRFISTFYKAPVFGIFRKTLRRQNEALLPNPWLFCVTVNSLTQLVLKSLKYDTYGVVARDISSILAVYCDTFDVLVSYKRSLVKNHSNSTNLDDDFKNLNSAANALHCGIIDITEKFQDFFTQLNLSPRIERRCWVLFREYKSNS
Protein: Glucose-signaling factor 2 (Extracellular mutant protein 6) (Q04697)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in the secretion of hexose transporters from the endoplasmic reticulum. Involved in secretion of GAL2 and HXT1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL39
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS21B
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL18
Sequence:
MEIYIRLNADVEHDYAFQVSNEDTINNKIKKIFPSKTGLADLMVLRPSIFHEKEPVKFYKSIHPGYLSEGGCLMFHYEADNEENLEELNDSKPLIDQLWPGQLVVPEWKLSKKNIWVYTIIMLAWLYTDLPDAISPTPGICLTNQLSRLLIPVAKHMDLPEIAAKLEQEVQANYSSLVAQWLFFVMHIFKVGIITLFLKLGIANPISFNPYKLWSLRDLTSPSANGAKNSGGNNNTTDLKTRLRSLGWIGAKRATYDDYQTNYYNYVIDKMGGAVAAYRAGAIRKAAAPGIQLVAGEGFQSPLEDRFTASTFTAIKTERKFILSEEYFVELENNLKKILEEYDGDIGKMNAEIRRFRRFGIYEPDEKLASLVKLRREIADEKEKASNNDATFGIKKNDLKKSN
Protein: Leukocyte immune-type receptor TS32.15 L1.1a (Q0GKX6)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
IFRGETVTLTCRISGWSGPYYWYKDGVYSHGSAENYYTIKADQSHRYRCYGSIDGRSTAWSDEVTLSVIERPKAVLTLQPDGQIFSGQEVTFTCEIRGHADTEWMYNWYKDGVQISSYTESRKYSFTAVESLSAKYTCSGRRRSDSQTSETSNTVTLTVSEKPKPELTASREGAVLKGNSLTLSCTLKLQSAGWKFYWIKPTQSTETETETDYYNISSVRDSDGGQYRCRAGRGNPVYYTHYSDAXWVNVTESPKAVVTIKPDKHVFRGETVTLRCEIQGGGDTEWTYSWDKKYNTLYSSRTTQEFSFSSVINDDSAEYTCRGRRSDSQSSEISDAVTLTVSDAAEAVVSVSPLRWLTEGDSVTLSCEVKHSSTGWTFTWYTEVPSRDSQGSLRYSTALLSDSSRGSGGSYTLSPVTVKHTGVYMCRAERGEPVFHTRDSNLQPLCITGESPPVSLIINPSRTQHFTADSLSLSCEDQSDSTGWTVRGYTHSEAVSDCSSVSGSTCNISSLSTSHTGVYWCQSESGGRSNPVNITVHRGHVILDSPVHPVTEGHPLTLHCLSRNSKTSASGVDFYKDGSVLQNKTTGEMTISTVSKSDEGFYHCKHPERGESPKSWVSVRDSGSGSSTDIVFVSVGLSLAFLFIILLLILRWWHKSIKGKDRDIQQNSNQTPGQNPSQSGAEDSQSGHTPLQTDVHIYGTVENASKSEAAAELSGAVYAQVMKKKESYKNKDDDAGPSDVIYTELEIKPQKKAKKNQVKASVEYETIYSQLKQNT
Protein: Brachyury 2 (A0A3Q4EGG8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE
Protein: Tafazzin family protein (A0A8I6AB32)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side {ECO:0000256|ARBA:ARBA00004137}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00024323}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00024323}; Intermembrane side {ECO:0000256|ARBA:ARBA00024323}.
Interaction partners:
Sequence:
MPLHVKWPFPAVPRLTWTLASSVVMGLVGTYSCFWTKYMNHLTVYNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGKVNMSSEFLRFKWVGIGRLIAECHLNPIILPLWHVENHRADWEALQYTPCA
Protein: Protein kinase wis1 (EC 2.7.12.2) (Protein kinase sty2) (P33886)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1.
Interaction partners:
- Mitogen-activated protein kinase sty1
- Response regulator mcs4
- MAP kinase kinase kinase win1
- MAP kinase kinase kinase wis4
- Protein kinase byr2
- Transcription factor atf1
- Tyrosine-protein phosphatase 1
- Protein kinase byr1
- Tyrosine-protein phosphatase 2
- M-phase inducer phosphatase
Sequence:
MSSPNNQPLSCSLRQLSISPTAPPGDVGTPGSLLSLSSSSSSNTDSSGSSLGSLSLNSNSSGSDNDSKVSSPSREIPSDPPLPRAVPTVRLGRSTSSRSRNSLNLDMKDPSEKPRRSLPTAAGQNNIGSPPTPPGPFPGGLSTDIQEKLKAFHASRSKSMPEVVNKISSPTTPIVGMGQRGSYPLPNSQLAGRLSNSPVKSPNMPESGLAKSLAAARNPLLNRPTSFNRQTRIRRAPPGKLDLSNSNPTSPVSPSSMASRRGLNIPPTLKQAVSETPFSTFSDILDAKSGTLNFKNKAVLNSEGVNFSSGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAVSPYIVDFYGAFFVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYAVVQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKTNIGCQSYMAPERIRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPDSFSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDMASWAKGALKEKGEKRS
Protein: F-box domain-containing protein (Q9TZ27)
Organism: Caenorhabditis elegans
Interaction partners:
- Uncharacterized protein
- E3 ubiquitin-protein ligase hecw-1
- Fibrinogen C-terminal domain-containing protein
- Saposin B-type domain-containing protein
- Basic proline-rich protein
Sequence:
MVDIDSKTHQRNLVMPPFLNMDLLVTNLVLEKMDLVDLLSARKVCRSLRTAVDEFGLRFGVIVFLLRKDKVEIWWGETEIIYTKTANGSTNVFHNEQTKLIDGENFMERAAKDFKIVSKHARKNYIVNFTKNRCDIVTTFIKIFKAEKCIHVKEIDLSTFGFDEVLTILSWFDSKELKTIELRWMDSIDRFERITQLEQWKNAEVVKIDCSEIASTMIVHFFHFKCFTINRTDEFPAQAAIQMRDDLLRRSTFQSCDISFYKSKTNPIEIAKVFKPDYTGENVFKIEFSNGNDKFDISLQEVSDYFYLNMKRSLSV
Protein: Forkhead box protein D5-B (FoxD5-B) (FoxD5b) (Fork head domain protein 3) (Fork head domain-related protein 12') (xFD-12') (Forkhead-like) (xFLIP) (XlFoxD5b) (Q9PT68)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor (By similarity). Controls the convergence and extension movements of medial neural plate precursors during gastrulation.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MSFSQESGTHHNSLDYAGVSDEEDEIDILGEDDPCSLKSHFYLQPTHSDMGDSGMLSPSKLSCTESESDSSGESEGGTSKDSPATSPGGKAKRALVKPPYSYIALITMAILQSPHKKLTLSGICDFISSKFPYYKDKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPASEDMFDNGSFLRRRKRFKRHQQEFFKDGLMMYNSLPYYRPYSALQPQPMLQQTPLACMAIPETLSMPTNLTPYPDIKRKAHYPDQGAHRGFEGQDANNHPNKSQSKCSFSIENIMKKPKEPEPSFPSFNSHWNYNNHLLQRPSSCFLPAVLNLSTGPLLANVQGTRQYNLIKFPGSY
Protein: Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved into: Mature secreted glycoprotein G (Mature sG)] (P03423)
Organism: Human respiratory syncytial virus A (strain A2)
Function: Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).
Subcellular location: [Isoform Membrane-bound glycoprotein G]: Virion membrane {ECO:0000269|PubMed:15958665}; Single-pass type II membrane protein {ECO:0000303|PubMed:2164608}. Host cell membrane {ECO:0000269|PubMed:15958665, ECO:0000269|PubMed:28939853}; Single-pass type II membrane protein {ECO:0000303|PubMed:2164608}.; SUBCELLULAR LOCATION: [Isoform Secreted glycoprotein G]: Secreted {ECO:0000250|UniProtKB:P20895}. Note=The protein is shed from infected cells before the appearance of progeny virus (By similarity). The initiation at the downstream methionine removes a portion of the transmembrane domain. The remaining hydrophobic portion of the sG protein is essential for translocating it into the lumen of the ER during translation and would likely maintain its membrane association until a proteolytic event releases the mature sG protein into the medium (By similarity). {ECO:0000250|UniProtKB:P20895}.
Interaction partners:
Sequence:
MSKNKDQRTAKTLERTWDTLNHLLFISSCLYKLNLKSVAQITLSILAMIISTSLIIAAIIFIASANHKVTPTTAIIQDATSQIKNTTPTYLTQNPQLGISPSNPSEITSQITTILASTTPGVKSTLQSTTVKTKNTTTTQTQPSKPTTKQRQNKPPSKPNNDFHFEVFNFVPCSICSNNPTCWAICKRIPNKKPGKKTTTKPTKKPTLKTTKKDPKPQTTKSKEVPTTKPTEEPTINTTKTNIITTLLTSNTTGNPELTSQMETFHSTSSEGNPSPSQVSTTSEYPSQPSSPPNTPRQ
Protein: Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) (Q8C0Q2)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H4I2, ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MASKRKSTTPCMIPVKTVVLPGASTEPQPVESLPEGPQQDLPSEAPDASSEAAPNPSSTDGSALANGHRSTLDGYVYCCKECEFRSQDVTHFIGHMNSEHTDFNKDPTFVCTGCSFLAKNPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPDSASSSVLAGESTTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPNQPGSEALPKPLAGEREVKEGDHTFINGAAPGSQASAKSTKPPPAANGPLIGTVPVLPAGIAQFLSLQQQPPVHAQHHTHQPLPTSKTLPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQATLPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPTVAPINTVCSNSASAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGSRAMMPGEHGSVLIDSVPEVPFPLASKVPEVTCIPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLENSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKKVNTEETKKADGHMPKEEEEGAEQEGRDEELANELRVPGENGSPEMFLSHALAERKVSPIKINLKNLRVTEASGKSEFPGMGVCEPEEDGLNKLVEQPPSKVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLCEEDLQTLCDKTQMSAQQVKQWFAEKMGEETRAVADISSEDQGPRNGEPVAVHKVLGDAYSELSENSESWEPSAPEASSEPFDTSSPQSGRQLEAD
Protein: DNA-directed RNA polymerase subunit Rpo4 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit F) (B8YB58)
Organism: Saccharolobus shibatae (strain ATCC 51178 / DSM 5389 / JCM 8931 / NBRC 15437 / B12) (Sulfolobus shibatae)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Probable). The highly mobile Rpo4/Rpo7 heterodimer stalk is conditionally required for transcription initiation (Probable).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00864, ECO:0000269|PubMed:22848102}.
Interaction partners:
Sequence:
MSSVYIVEEHYIPYSVAKKLLSDVIKSGSSSNLLQRTYDYLNSVEKCDAESAQKVVEELSSIISREDVRAVLASICPITPDEVRSILIMDSNRTYTSEDIQKIIDIIRKYIKS
Protein: Ammonium transporter 1 member 2 (AtAMT1;2) (Q9ZPJ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ammonium transporter probably involved in ammonium uptake from the soil.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nitrogen regulatory protein P-II homolog
- High affinity nitrate transporter 2.4
- Glutamine synthetase cytosolic isozyme 1-3
- Glutamine synthetase, chloroplastic/mitochondrial
- Glutamine synthetase cytosolic isozyme 1-1
- Glutamine synthetase cytosolic isozyme 1-5
- Protein NRT1/ PTR FAMILY 6.3
- Glutamine synthetase cytosolic isozyme 1-2
- Ferredoxin--nitrite reductase, chloroplastic
- CBL-interacting serine/threonine-protein kinase 23
Sequence:
MDTATTTCSAVDLSALLSSSSNSTSSLAAATFLCSQISNISNKLSDTTYAVDNTYLLFSAYLVFAMQLGFAMLCAGSVRAKNTMNIMLTNVLDAAAGAISYYLFGFAFAFGTPSNGFIGRHHSFFALSSYPERPGSDFSFFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSTFLTGFVYPTVSHWFWSSDGWASASRSDNNLLFGSGAIDFAGSGVVHMVGGIAGLCGALVEGPRIGRFDRSGRSVALRGHSASLVVLGTFLLWFGWYGFNPGSFLTILKGYDKSRPYYGQWSAVGRTAVTTTLSGCTAALTTLFSKRLLAGHWNVIDVCNGLLGGFAAITSGCAVVEPWAAIVCGFVASWVLIGFNLLAKKLKYDDPLEAAQLHGGCGAWGLIFTGLFARKEYVNEIYSGDRPYGLFMGGGGKLLAAQIVQIIVIVGWVTVTMGPLFYGLHKMNLLRISAEDEMAGMDMTRHGGFAYAYNDEDDVSTKPWGHFAGRVEPTSRSSTPTPTLTV
Protein: Extensin-like (A4GXC2)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MTPSAPLPFTVILLLAPTQSHYYVPQIISRAPLQKFGLSPLQCPSNGRTLPPNSTIRPYRPFQTPPYWNTSASPYPHTYDRNTPSPTPLLSLPLPPAKDT
Protein: Voltage-gated delayed rectifier potassium channel KCNH4 (Brain-specific eag-like channel 2) (BEC2) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Potassium voltage-gated channel subfamily H member 4) (Voltage-gated potassium channel subunit Kv12.3) (Q9UQ05)
Organism: Homo sapiens (Human)
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
Protein: Glycine--tRNA ligase, chloroplastic/mitochondrial 2 (EC 6.1.1.14) (Glycyl-tRNA synthetase 2) (GlyRS-2) (Protein EMBRYO-DEFECTIVE-DEVELOPMENT 1) (Q8L785)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11278923}. Mitochondrion {ECO:0000269|PubMed:11278923, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Putative glycine--tRNA ligase, cytoplasmic
- Glycine--tRNA ligase, mitochondrial 1
- Valine--tRNA ligase, mitochondrial 1
- Class II aaRS and biotin synthetases superfamily protein
- Proline--tRNA ligase, chloroplastic/mitochondrial
- Leucine--tRNA ligase, chloroplastic/mitochondrial
- Leucine--tRNA ligase, cytoplasmic
- Aspartate--tRNA ligase, chloroplastic/mitochondrial
- Valine--tRNA ligase, chloroplastic/mitochondrial 2
- Isoleucine--tRNA ligase, chloroplastic/mitochondrial
Sequence:
MAILHFSLPLIVSFLRPHASPRFFLLPRSLSQSPFLSRRRFHRTSAVSSAAVHHQSYRNPDDDVTRAVSVPTFQQAIQRLQEYWASVGCAVMQPSNTEVGAGTMNPCTFLRVLGPEPWNVAYVEPSIRPDDSRYGENPNRLQRHTQFQVILKPDPGNSQQLFINSLSALGIDVTAHDIRFVEDNWESPVLGAWGLGWEIWMDGMEITQFTYFQQAGSLPLSPVSVEITYGLERIIMLLQEVDHFKKILYADGITYGELFLENEKEMSSYYLEHASVDRLQKHFDYFDEEARSLLALGLPIPAYDQLLKTSHAFNILDARGFIGVTERARYFGRMRSLARQCAQLWLATRESLGHPLGVASEPVPPVCHRAALEKVAEKVSEDPRSFIIEIGTEEMPPQDVINASEQLRVLVLELLENQRLRHGAVKAFGTPRRLVVLVDAMSSKQLEEEVEVRGPPASKAFDDEGNPTKAAEGFSRRYGVPLEKLYRKVSGKTEYVHARVTEPARLALEVLSEDLPGILAKISFPKSMRWNSSVMFSRPIRWVMALHGDLVVPFSFAGISSGNVSCGLRNTASASLLVQNAESYEDTMRNSGINIEIEERKKIILEKSNALAKSVSGRLVVPQNLLNEVANLVEAPVPLIGKFKESFLELPEELLTIVMQKHQKYFSIIDESGQLLPYFIAVANGAINEDVVKKGNEAVLRARYEDAKFFYEVDTRKRFSEFRDQLQGILFHEKLGTMLDKMNRLKKMVSKLCLALKIDEDLLPVVEDAASLAMSDLATAVVTEFTALSGIMARHYALRDGYSEQIAEALLEITLPRFSGDVIPKTDAGMVLAIGDRLDSLVGLFAAGCQPSSTNDPFGLRRISYGLVQILVEKDKNVNFKRVLELAASVQPTKVEANTVEDVYQFVTRRLEQLLVDNGVSPEVVRSVLAERGNNPCLAARTAYKTEKLSKGEMFPKIVEAYSRPTRIVRGKDVGVGVEVDENAFETPQERTLWSTYTSIKDRIHTGIEIEDFTEISMQLVEPLEDFFNNVFVMVEEERVRKNRLALLNNIANLPKGVIDLSFLPGF
Protein: Serine hydroxymethyltransferase (EC 2.1.2.1) (PfSHMTc) (Q8I566)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the interconversion of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, a source of one-carbon units used by thymidylate synthase to convert dUMP to dTMP for DNA synthesis. Binds to its own mRNA and to the mRNA of bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) in vitro; the physiological relevance of this interaction is not clear.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21129192}. Mitochondrion matrix {ECO:0000269|PubMed:21129192}. Plastid, apicoplast {ECO:0000269|PubMed:21129192}. Nucleus {ECO:0000269|PubMed:21129192}. Note=Predominantly localizes to the cytoplasm in early trophozoites and postmitotic schizonts. Transiently localizes to the mitochondrion and the apicoplast in late trophozoites and in mitotic schizonts. Partially localizes to the nucleus, especially in late trophozoites and in mitotic schizonts. {ECO:0000269|PubMed:21129192}.
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Glycine cleavage system H protein
- Aminomethyltransferase, mitochondrial, putative
- Methionyl-tRNA formyltransferase, putative
- Dihydrolipoyl dehydrogenase
- Dihydrolipoyl dehydrogenase, apicoplast
- 5-aminolevulinate synthase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast
- Adenylosuccinate lyase
Sequence:
MFNNDPLQKYDKELFDLLEKEKNRQIETINLIASENLTNTAVRECLGDRISNKYSEGYPHKRYYGGNDYVDKIEELCYKRALEAFNVSEEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDLFESKLYKCNSEGYVDMESVRNLALSFQPKVIICGYTSYPRDIDYKGFREICDEVNAYLFADISHISSFVACNLLNNPFTYADVVTTTTHKILRGPRSALIFFNKKRNPGIDQKINSSVFPSFQGGPHNNKIAAVACQLKEVNTPFFKEYTKQVLLNSKALAECLLKRNLDLVTNGTDNHLIVVDLRKYNITGSKLQETCNAINIALNKNTIPSDVDCVSPSGIRIGTPALTTRGCKEKDMEFIADMLLKAILLTDELQQKYGKKLVDFKKGLVNNPKIDELKKEVVQWAKNLPFA
Protein: Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (A0A0G2JWW8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 6
Sequence:
MSTPPLAPTGMASGPFGGPQAQQAAREVNTATLCRIGQETVQDIVYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDHLRQLSILFRKLRLVYDKCNENCGGMDPIPVEQLIPYVDEDGSKNDDRAGPPRFASEERREIAEVNKKLKQKNQQLKQIMDQLRNLIWDINAMLAMRN
Protein: Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Q59P87)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 4
- Serine/threonine-protein kinase SSN3
- Mediator of RNA polymerase II transcription subunit 18
Sequence:
MSAQTDQPITEQQKKEQEQYTNLINSLPTRWEIELEFVQSLSNIPYVNYLAQNNYFNDENFINYLNYLQYWTQPEYSKFLVYPNCLHILKLLQDENFRKNIINQDFMNSLMNDMVKRWQSNANDQDENKEKEENKEVPEVRINGTN