wanglab/gogpt-training-data huggingface dataset:
Protein: Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (SAPK-alpha) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (p54-alpha) (P49186)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock. Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P45984}. Nucleus {ECO:0000250|UniProtKB:Q9WTU6}. Note=Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:Q9WTU6}.
Interaction partners:
- Transcription factor Jun
- Dual specificity mitogen-activated protein kinase kinase 4
- C-Jun-amino-terminal kinase-interacting protein 1
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 8
- Transcription factor JunD
- Dual specificity mitogen-activated protein kinase kinase 7
- Apoptosis regulator Bcl-2
- C-Jun-amino-terminal kinase-interacting protein 2
- Cellular tumor antigen p53
Sequence:
MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSINDISSMSTEHTLASDTDSSLDASTGPLEGCR
Protein: Flavin adenine dinucleotide transporter (A0A1D8PJ45)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLSSVFFSILTLLLSCFVSTTEARRKLSATSLVTCMDNSQISPSYFNVTFNPDDRSLRYALDLTTSISAYITAHVQVYAYGFLIIEKDINVCSLGWKQFCPIFPGALQIDSVQYISSEYTKQIPGIAYQVPDIDAVVKLVVKERDSGDTLSCLQANFSNGKTISQTGVKWATACIAGLGLIVAAMLSTFGNSNAASHISANSLSLFLYFQSVVVVSMQAVERVPPIASAWSENLAWSMGLIRIQFMQNIFRWYIQSTGGSPTTYFISSTKQVLVQKHKRSLDYVAGVAKRSLEYALRSHSNLYVLRGIKRIGYNSKIEPTSIVATGYTWFVLIGYLLVVLLVLVKSVIILLTRAKKINPRTFNSFRGSFPNLIKGSLLRYIAIGSTQLIIFSLWEFTQNDSPAMVVLAVLFVLLLLGVLGWSYFNVMKIGRQSIRTYNNPAALLYGDNKVLQKWGFCYTMFHANKYWFGVVLMGYNVFKALFIAFCQDAGKVSVLPIFVADLAYTIYLIWTGPYLNKPTNVINYMMSIVTTINSFLFLFFSDLFGQPAPVASIMGWVFFILNAAFSLILLILVIVFVLLSVMSKNPDARFAPAKDDRFSFQRKSSIKHKSLTEKTGFSNTNGGHGGVGGGDEELTALGVAAQDHSADWESQMYKLNDLSLDEEDDSRTNQDFVRPDKTRELTSDYDDDTSFTNEDNTRVVNNEEDKNKKLAEKWKSKISRKLSKKKSLKDKNNNTPTTTNNNITTVRRLSDTLLNDERDSNEKREENDELSPITHPYNQSTSFNNHKREHSTTSTISNNNPTHTKGFI
Protein: UBX domain-containing protein 3 (Meiotically up-regulated gene 39 protein) (Q9UT81)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion and sporulation.
Interaction partners:
- Cell division cycle protein 48
- UBX domain-containing protein 2
- Putative ubiquitin thioesterase otu1
- Ubiquitin homeostasis protein lub1
- Uncharacterized derlin-like protein C365.08c
- UBX domain-containing protein 10
- Ubiquitin conjugation factor E4
- Ubiquitin fusion degradation protein 1
- ATPase family gene 2 protein
- Nuclear protein localization protein 4
Sequence:
MDREDILKEFCNRNNIDVSQGRFFLESTNWNYELATALLHEVIPPEEDHGLQPSSDVSKVPEVTGSSSGISGGDQQPPRPLQRQQNTQGQGMKSGTASKKFATLRDLEGNDESAEEKSHLFTGGEKSGLSVEDGDPDPKKQLVRDILEKARQHTISPLDEQDSGPSSLASSWASVGQRLGTENEASGSTTPVTQSGPPRENPPTESQPEKPLRRTLYFWRNGFSVDDGPIYTYDDPANQEMLRYINSGRAPLHLLGVSMNQPIDVVVQHRMDEDYVAPFKPFSGKGQRLGSTYMQPRMSQMPGGLYTDTSTSSSVPINVKPNSTTPHASLQIDENKPTTRIQVRLSNGGRTVLTVNLSHTLHDIYEAVRAVSPGNFILSVPFPAKTLEDDPSVTVEAASLKNASLVQKSL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4J0N1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDPATNSPIMPIDLPIMHDSDRYDFVKDIGSGNFGVARLMTDRVTKELVAVKYIERGEKIDENVQREIINHRSLRHPNIVRFKEVILTPSHLAIVMEYAAGGELYERICNAGRFSEDEARFFFQQLISGVSYCHAMQICHRDLKLENTLLDGSPAPRLKICDFGYSKVLFISLKSSVLHSQPKSTVGTPAYIAPEILLRQEYDGKLADVWSCGVTLYVMLVGAYPFEDPQEPRDYRKTIQRILSVTYSIPEDLHLSPECRHLISRIFVADPATRITIPEITSDKWFLKNLPGDLMDENRMGSQFQEPEQPMQSLDTIMQIISEATIPTVRNRCLDDFMADNLDLDDDMDDFDSESEIDVDSSGEIVYAL
Protein: Cathelicidin (Q49S73)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKVQVRSLILLAVAVLQVRSQNQTETRYEDIILVALPQLLPGEEQAFRPILNQLQVETLNTEDVDQSEVSVRLTFPIQETFCSKSQGQPGKPCPLKKNGKLMMCSMKVRHPILEASNNLNTDLSTFVCEYMDAEDALQQKIRTRRSKVRICSRGKNCVSRPGVGSIIGRPGGGSLIGRPGGGSVIGRPGGGSPPGGGSFNDEFIRDHSDGNRFA
Protein: Vitronectin (F5GX75)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAPLRPLLILALLAWVALADQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLTSDLQAQSKGNPEQTPVLKP
Protein: Glyceraldehyde-3-phosphate dehydrogenase 2 (GAPDH 2) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (PL-sensitive glyceraldehyde-3-phosphate dehydrogenase) (Q829W3)
Organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MTIRVGINGFGRIGRNYFRALLEQGADIEIVAVNDLGDTATTAHLLKYDTILGRLKAEVTHTADTITVDGKTIKVFSERNPADIPWGELNVDIVIESTGIFTKKADAEKHIAGGAKKVLISAPASDEDITIVLGVNEDKYDPAKHNVISNASCTTNCVAPMAKVLDENFGIVKGLMTTIHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKMDGISMRVPVPTGSATDLVVEVSREVTKDEVNAAFKKAAEGELQGYLSYTEDPIVSSDIVGDPSSCTFDSAMTMVMEGTSVKILGWYDNEWGYSNRLVDLTVFVGNQL
Protein: Zinc finger protein 383 (Q8NA42)
Organism: Homo sapiens (Human)
Function: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.
Subcellular location: Nucleus {ECO:0000269|PubMed:15964543}. Cytoplasm {ECO:0000269|PubMed:15964543}. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.
Interaction partners:
- Zinc finger and BTB domain-containing protein 25
Sequence:
MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQGKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDVLEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFSQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSYLSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQHARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIHTGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEKPYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK
Protein: Uncharacterized protein YcjY (P76049)
Organism: Escherichia coli (strain K12)
Interaction partners:
- HTH-type transcriptional regulator PgrR
- Putative carboxymethylenebutenolidase
- Murein peptide amidase A
Sequence:
MMNNKVSFTNSNNPTISLSAVIYFPPKFDETRQYQAIVLSHPGGGVKEQTAGTYAKKLAEKGFVTIAYDASYQGESGGEPRQLENPYIRTEDISAVIDYLTTLSYVDNTRIGAMGICAGAGYTANAAIQDRRIKAIGTVSAVNIGSIFRNGWENNVKSIDALPYVEAGSNARTSDISSGEYAIMPLAPMKESDAPNEELRQAWEYYHTPRAQYPTAPGYATLRSLNQIITYDAYHMAEVYLTQPTQIVAGSQAGSKWMSDDLYDRASSQDKRYHIVEGANHMDLYDGKAYVAEAISVLAPFFEETL
Protein: Protein kinase domain-containing protein (G3MTX3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSSGMLGATQFMPQNSSHPSTSVMMQQVPPQNGGATRSSPTEMQQCMQAMSEDSIEMRDYNSGVHHMHPHQMQMQQQQQHHQQQYNMSYHNHQQQMQQMHYHQQQQQYQQQQAQHHQMYAPQIQQQQQQPQQQSQQQSAQQPQQSSAALQHVNESSNLSSAGSISDREPEQHGGTPQRPTAPQSSTATDKKTRKRRKAGPTEDQATPKQERKITEFMKVGGEVASGNSVARCLLTEYHQNQGSPKRQPAVQQNGSNSYDSQQQQPQMNQHEMQNSYWGVATPSLGVNNRGTPTPTQQQHYSSDSNSNSNQSPPGQGNQSGRMVRTIDEETQTDSSLSQANPQNADEVAKMNRIIEDHRRQIEELNSKNSLERRKNEASKETIKRLLIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERNEIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPSTSSNTNGDDAIFRRPEEPKEIQYQEYIELDEIYKLRREHLRKEETDLSMEKERLEKEKQHHVRELKRASNESASQFNDHRLLHKRYLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTYWYLPPETFIVPPPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELFRPRGAIRASVAGSLLLVIITLCQHSNRSEDRLCVSNV
Protein: Sodium/hydrogen exchanger (B7YZY1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSIRTEQDYDSATPALAQQMNLARRACWRIKSYSSESLFKTYASVITDTSANEIDAEAPPPPRDKTKTRIEPQIAPAKRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGRWAPPTIYTTCPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNAEECQQNPNEINVVGPSDDWDDGLTFTAKSSLAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKRQGDECTDAVQQNEFPAWASNKEYLAYNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSSQPPNAPSTSIHNPRLDKRSQSISSSSLGAGAHQLGPEGHSGPFPVTASHRRNVRRGSMLELSGDTIPEESSYQHGHSKSLCEPADSDEWEGAPLSAAGGANSELLMRMSGREPLLPRPSNTPRAQIRRMNAGAVGGAGVSQAGRKNQVTKALLDYEDSETDSDENDDDEDEDFDSYDDENIVVTTFTTPATGRRPGSSPGSGSEANTATTTTTSIRLTRNNDESII
Protein: Type I inositol polyphosphate 5-phosphatase 1 (At5PTase1) (EC 3.1.3.56) (Q84MA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but not toward Ins(1,4)P2, Ins(1)P. Seems to be involved in the abscisic acid (ABA) signaling pathway. Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Interaction partners:
- Phosphoinositide phospholipase C 7
- Phosphoinositide phospholipase C 2
- Type I inositol polyphosphate 5-phosphatase 2
- 3',5'-bisphosphate nucleotidase 2
- Multiple inositol polyphosphate phosphatase 1
- Probable 3'
- 3'
- Probable 3'
- Inositol 1,3,4-trisphosphate 5/6-kinase 4
- Inositol-tetrakisphosphate 1-kinase 3
Sequence:
MAEVRSRSRRTESNWATICCSAFSCLQLYWARIVLRKWFNVSASESDYSADSDDDYEDRSQEFDPISSGVTNPRVDTDGNVIYRPKLRRRNSETFRMQYIDTKAIRICAGTWNVGGRVPSSDLDIDGWLDTLEPADIYVLGLQEIVPLNAGNIFGMEDDQPALEWENLIRDALNRVQPRKLKIKSHSDPPSPSKFKQPEEVPYSVEDMFVETSHDACDGISSMDNKLNSVESTDVPIVSEDSLTNIDVLGSTNDNASCLPIQEYLQRQFSTPNTPDRSLSMQINSDSKREERFSYTERVGLSWPEPPLRLLNQYVSERRGSFKSVNLTITNLRKPSYVRIVSKQMVGVFLTIWVRRNLRKHISNLCVSTVGVGIMGYIGNKGSVSVSMSIYQTPFCFLCTHLSSGEKDTDQEKRNDDVREIHRRTQFLPHSLNANELPRSICNHERIIWLGDLNYRINLSYEKTHELIARKEWQRLVEYDQLSREMTKGNLFEGWSEGTLDFAPTYKYEIDSENYIGDDPESGKRRPAWCDRIIWNGKGMKLFNYRRNEIKLSDHRPVTATFLAEVEVLSPRKLQHALTLTYAEIQGLDA
Protein: Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) (Q4TWT4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSPPQLLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIKHTTLSERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTPQAEANPLSQKIALVGGEPASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSLGTKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKAAAGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLPYLSPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAPLQFRGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQGLPLDTPAALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVTNVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEEDWTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPNITDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAISDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKANPPPVDGPFWDGQSPPTPVHQKGKPVVRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDAEQVKATPPASNGAPNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCADSGYQAIEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGVEEKIFYTHALSQCQ
Protein: Transthyretin (ATTR) (Prealbumin) (TBPA) (P02766)
Organism: Homo sapiens (Human)
Function: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Subcellular location: Secreted. Cytoplasm.
Interaction partners:
- Retinol-binding protein 4
- Albumin
- Apolipoprotein A-I
- Amyloid-beta precursor protein
- Thyroxine-binding globulin
- Beta-2-microglobulin
- Alpha-1-antitrypsin
- Apolipoprotein E
- Serum amyloid P-component
- Alpha-2-macroglobulin
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Protein: Gibberellin receptor GID1B (EC 3.-.-.-) (AtCXE14) (Carboxylesterase 14) (GID1-like protein 2) (Protein GA INSENSITIVE DWARF 1B) (AtGID1B) (Q9LYC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and flower development. May function as a dominant GA receptor at low GA concentrations in germination. Partially redundant with GID1A and GID1C.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DELLA protein RGA
- DELLA protein GAI
- DELLA protein RGL1
- DELLA protein RGL2
- DELLA protein RGL3
- Gibberellin receptor GID1A
- F-box protein GID2
- Gibberellin 3-beta-dioxygenase 1
- Gibberellin receptor GID1C
- Gibberellin 20 oxidase 1
Sequence:
MAGGNEVNLNECKRIVPLNTWVLISNFKLAYKVLRRPDGSFNRDLAEFLDRKVPANSFPLDGVFSFDHVDSTTNLLTRIYQPASLLHQTRHGTLELTKPLSTTEIVPVLIFFHGGSFTHSSANSAIYDTFCRRLVTICGVVVVSVDYRRSPEHRYPCAYDDGWNALNWVKSRVWLQSGKDSNVYVYLAGDSSGGNIAHNVAVRATNEGVKVLGNILLHPMFGGQERTQSEKTLDGKYFVTIQDRDWYWRAYLPEGEDRDHPACNPFGPRGQSLKGVNFPKSLVVVAGLDLVQDWQLAYVDGLKKTGLEVNLLYLKQATIGFYFLPNNDHFHCLMEELNKFVHSIEDSQSKSSPVLLTP
Protein: Target of rapamycin complex subunit LST8 (TORC subunit LST8) (Lethal with SEC13 protein 8 homolog) (Q5D6Y8)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Endosome {ECO:0000256|RuleBase:RU369068}.
Interaction partners:
Sequence:
MKVVGAVNTVVLHPNQTELISGDQNGNIRVWDLTANSCSCELVPEVDTAARSLTVMWDGSLVVAANNHGTCYVWRLLRGNQTMTNFEPLHKLQAHSGYILKCLLSPEFCEPHRYLATASSDHTVKIWNVDGFTLEKTLIGHQRWVWDCVFSVDGAYLITEMVKLLHPWVSKPNPWFPSKIKEKIFIYHLRLPSPPCLAPFCSLFLFNRSHFG
Protein: SKP1-like protein 9 (AtSK9) (Q9LSX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-1
- Cullin-2
- Cullin-like protein 3
- Putative cullin-like protein 1
- Putative cullin-like protein 2
- RING-box protein 1a
- RING-box protein 1b
- F-box protein 7
- Elongin-C
- Protein TRANSPORT INHIBITOR RESPONSE 1
Sequence:
MSTKKIILKSSDGHSFEVEEEAARQCQIIIAHMSENDCTDNGIPLPNVTGKILAMVIEYCNKHHVDAANPCSDDDLKKWDKEFMEKDTSTIFDLIKAANYLNIKSLFDLACQTVAEIIKGNTPEQIREFFNIENDLTPEEEAAIRRENKWAFE
Protein: carbonic anhydrase (EC 4.2.1.1) (P96878)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Beta-carbonic anhydrase 1
- Carbonic anhydrase 2
- Mycoketide-CoA synthase
- Probable fatty acyl-CoA transferase Rv3272
- Phthioceranic/hydroxyphthioceranic acid synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Mycocerosic acid synthase-like polyketide synthase
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Cytochrome bc1 complex cytochrome b subunit
- Probable polyketide synthase Pks17
Sequence:
MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ
Protein: Bromodomain containing 8 (A0A8I5Y6W9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
TSLMLQCTSRLFSFCRVSVSRAIKPFAEPGRPPDWFSQKVSYQSDFLLYSLEYEIEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEAGGHTQLPRQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMPVPSGHLSSTGVLLEVGGVLPMIHGGDIQPATSAVAASPAASGAPTLSRLLEAGPTQFSTPLPSFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTPESVAPVSQPEPCVPLEAVGDPQTVTVSMDSSEISMIINSIKEECFRSGVAEAPGGSKAPSIDGKEDLDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEESETKGIHELVDIRDSGVEIKVEPTEPEPGMSGAEIVAGVGPVPSLEPPELRSQDLDEEPRSSAAGEMGEADGSSGKGEERPLPAVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEEEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLGDSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
Protein: Palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Abl-philin 2) (Zinc finger DHHC domain-containing protein 16) (DHHC-16) (Q9ESG8)
Organism: Mus musculus (Mouse)
Function: Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization. Also required for eye development. Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response. May be involved in apoptosis regulation. Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12021275}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tyrosine-protein kinase ABL1
Sequence:
MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKVCLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCVLPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFREAYAAIETYHQTPPPTFSFRERITHKSLVYLWFLCSSVALALGALTMWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFLGVDTGRHWLTRVLLPSSHLPHGNGMSWDPPPWVTAHSASVMAV
Protein: ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2) (Q96BM9)
Organism: Homo sapiens (Human)
Function: Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q9NVJ2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9CQW2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9NVJ2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CQW2}. Synapse {ECO:0000250|UniProtKB:Q9CQW2}. Note=Localizes with microtubules at the spindle mid-zone during mitosis. {ECO:0000250|UniProtKB:Q9NVJ2}.
Interaction partners:
Sequence:
MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQLQGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
Protein: Protein E6 (Q01197)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Secreted, cell wall {ECO:0000305}.
Interaction partners:
Sequence:
MASSPKLFSMSILFLFALFSMQIHAREYFSKFPRVNINEKETTTREQKHETFVPQTTQKPEEQEPRFIPETQNGYGLYGHESGSSRPSFTTKETYEPYVTPVRFHPDEPYNSIPESSNNKDTYYYNKNAYESTKQQNLGEAIFTEKGWSTKENQNNNYYNGNNGYNNGEKQGMSDTRYLENGKYYYDVKSENNYYPNRFDNSRGVASRNEFNENRYNNMGRYHQNQEEFEESEEEFEP
Protein: 5830443L24Rik protein (I6L9A3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTQPQMAPICLVENHNEHLSMNHEAIEILEKISQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALGVLLSSTFIYNSMNTISHDSLEKLHYVTELTELIRAKSSPNPDGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGYNPRVQASNSARECIRCFFPNRKCFVFDRPTHDRELLQKLETISEDQLDLKFREETNAFVSYIFNYAKIKTLKEGIKVTGNGLGILVTTYVDAINSGAVPCVDDAVTTLAQHENSVAVQRAADHYSEQMVQRLSLPTDTLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVVIC