wanglab/gogpt-training-data huggingface dataset:
Protein: Bone morphogenetic protein 8A (BMP-8A) (Osteogenic protein 2) (OP-2) (P34821)
Organism: Mus musculus (Mouse)
Function: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (By similarity). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Activin receptor type-1
- Activin receptor type-2A
- Activin receptor type-2B
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein receptor type-1B
- Chordin
- Bone morphogenetic protein 8B
- Noggin
- Neuroblastoma suppressor of tumorigenicity 1
Sequence:
MAMRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQREILAVLGLPGRPRPRAQPAAARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETADGHSMDPGLAGLLGRQAPRSRQPFMVTFFRASQSPVRAPRAARPLKRRQPKKTNELPHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFPLDSCMNATNHAILQSLVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
Protein: Cellular repressor of E1A-stimulated genes CREG (O76804)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKTFHSLLFALILALVSLDPSSGYSRRKDERIIREYKREQELNHAKIARDLVHRANWAAVGSLSTNERVKGYPMVNIISFDDSDANNRSTGRIRFLLTDLDFTGPDWQKDNKVTLLFSDEQTLRCKEGGKDPMEPTCARSMISGQVKKMDPSDKSYQPSLDAYVRRHPAAINWVKAHNFYLCELEISNIFVPDFYGGPHKVSASDYYAVSN
Protein: Sex-regulated protein janus-A (P20348)
Organism: Drosophila melanogaster (Fruit fly)
Function: JanA and janB regulate somatic sex differentiation.
Interaction partners:
Sequence:
MNRLQLLSKGLRLIHKMSEEALAGVPLVHISPEGIFKYVMINVFDGGDASKAVIRGFADCTWHADIFEREEEVFKKLGLRAECPGGGRIEHNPEKKYLKVYGYSQGFGKADHAQTKRILATKYPDYTIEISDEGY
Protein: E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.19) (Zgc:55773) (Q7ZVQ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAEQMSLLGLEDELTCSICLCLFDNPVSLICGHSFCANCLEETWKDKISSLFCPHCRMAFSSKPELKKNTVLGAVLDAYRVKAGISEPVKNPVEEKKKDPDAIKCDSCMEAKAVKTCLTCMASYCEGHVRPHRENAIFRAHQLCDPLPDLMERLCSDHGKLMEFYCIQHQSCICSTCLQYIHKGCEFITADERRFKQKTDLTDKLNMIEGKMDKNEQVITQMKEQQNKLKDLAATRKRILEAEYSQIREMIDRDEKEAMLAIDKEQERGQSKLVSLMKKFNENIEKMERTKCEINSLLDQSQSLTFLKASIDLPSVINFEPYNPRMNLDSKEVIAYHSSAVALKEWITKLMEQSTENRISVLKPEFEKSVLGTGYQSPGILGGTPAFLPNPRDMSYMRPPCSSKPKVLPSKKKNPDRRDTKEKPNRSKNPTQGINPVFSKSMDNLNELRPKTVDIIDINQPASSSAVQNVKRSDLLKYGTILHFDVRTAHKRISLSENNTKATVSDDPANYPEIPHRFSVCSQVLCTKGFSQGRHYWEIKMSSNNFCGLGLAYGKIDRKGPSSRLGRNAESWCVEWFNVKLSAWHNSFETVLENPNPSRVGILLDCDQGSATFYNVQDRAYPFHTFVFPFTEAVYPAFWIFSNGSSVSLCKLNN
Protein: Png2p (A0A1D8PHH2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- Bud21p
- Uncharacterized protein
- Beta-lactamase-related domain-containing protein
- Mitochondrial fission process protein 1
- Uncharacterized protein
- Major facilitator superfamily
Sequence:
MSSTIPSEDKKPLLDSEMEPEVSVNNNEELPPYSDNEKHSLLSDNEKCDLEEVPTSYRVTRHSNKFKRFCQILSLFGVLYLVNFLYINRDDFARGMSTHFRFNCGSLVSQQPLQETKLDHHPIFRNLIDVVDTTYSDQQEGNNTAKEIISVTNPYTPNPRYGESLYTTTLIKNHKFGNSWNQPAVVNFTAPSNISFDAVVLTLHTEVEGVQFDRLANLFVDGIQVWRTSTIEPGGRKVFSDFKKDVSKYSKLFKKENVQILFQLDNLVTSKLTGIFDVTLTADFYKFHRHPHYRDGKNEHNEKRYGHEDKLNEFYEEQNDQDYEKEFIDSFEHHRGDFQEDEKNHHDDHHKDKHHKGKHHKDDKHHKDKDGKPKKPEHPPHEPPHEPPHEPPHEPPHEPPHHPPHEPPHEPPHKPPHEPPHEPPHKPPHEPPHEPPHEPPHEPPHEPPHHPPHHPPHHPPHDPHDPNHHHGKYHEERRIFTEAKPADEIYPLTFNKNPNQAPVVYLASNKLSVNLPKVSKNTTRLTLSIFTSGNAADEFWYTNVVDKYKDIFADRGNPFIGKGPVRVVNVYFNGEKIAAQTPEPVIFTGGISPALWSPVVSFNAFDVPSIDVDVSGLLPYLWEHQAIEDKILEIEVSNGLGEIDKDTTTSVNENWVTSANLLTYQNDQVIDATGEVINIDNESSEVVLTVAPPYTRSLQQIIDASFSAQLISQFSLTLKNNRTLNTTISSYSKAEVSNVQSYSRSGDIQSIVHAGRSSRSVLIQDNDSPESKDVTEHKSKHRKSEIPENTISIVNITLNYPLVLHLQQISKDIGSGDDFFVDYDVRLAHSKSTDITFGAIHGGIHTTTSQNGTSRFFLSSKGNHGFGSTFSKYKSKIKFGPHQRKYKRVVNAVNGTIVLDKSKSGKDDEHGKTHLSSMMKAMEKTSVYKNASEMLQSIVNASKASFKEFLGAKPGCHGMKHHENEDGHKKMKHKMRKHLSDAH
Protein: 3-isopropylmalate dehydratase small subunit 1 (EC 4.2.1.33) (AtLEUD3) (Isopropylmalate isomerase small subunit 1) (IPMI SSU1) (Q9ZW85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. Plays an essential role in leucine biosynthesis. Functions in both the biosynthesis of leucine, and in the methionine chain elongation pathway of aliphatic glucosinolate formation. Plays an essential role in female gametophyte development.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:20663849}. Plastid {ECO:0000269|PubMed:32612621}.
Interaction partners:
- 3-isopropylmalate dehydrogenase 2, chloroplastic
- 3-isopropylmalate dehydrogenase 1, chloroplastic
- 3-isopropylmalate dehydrogenase 3, chloroplastic
- 2-isopropylmalate synthase 2, chloroplastic
- 3-isopropylmalate dehydratase large subunit, chloroplastic
- 2-isopropylmalate synthase 1, chloroplastic
- Dihydroxy-acid dehydratase, chloroplastic
- Methylthioalkylmalate synthase 1, chloroplastic
- Methylthioalkylmalate synthase 3, chloroplastic
- 3-isopropylmalate dehydratase small subunit 2
Sequence:
MAASLQSANPTLSRTLASPNKPSSFATFRSPFLRFNSTSVASNFKPLVSREASSSFVTRSAAEPQERKTFHGLCYVVGDNIDTDQIIPAEFLTLVPSNPEEYEKLGSYALVGLPASYKERFVQPGEMKTKYSIIIGGENFGCGSSREHAPVCLGAAGAKAVVAQSYARIFFRNSVATGEVYPLDSEVRVCDECTTGDVATVELREGDSILINHTTGKEYKLKPIGDAGPVIDAGGIFAYARKAGMIPSAAA
Protein: Amino acid transporter protein 6 (Q22397)
Organism: Caenorhabditis elegans
Function: Amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:22916205}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with nrfl-1 at the apical cell membrane of intestinal cells. {ECO:0000269|PubMed:22916205}.
Interaction partners:
- Na
- RNA
Sequence:
MLNVFGVSASMPDDSRSQKMGLLGAISYIVGNIVGSGIFITPTSIIENVNSVGLSLAIWILAAFISMLGSFCYVELGTSIRLSGGDFAYLCFMKWYPVAFAFMCIGCTINYPATLAVQAQTFAEYVFRGAGVELDETSEFWAKKLLGFSLIILLMFMNFFSLKTFVQRFSILASLAKIAATLLIIITGFYYLIFKHWKQNLEEPFKGSNWNPGPFVNALFAGLFSYDGWDILNFGAEEIENPKRTMPLSIIIGMTCIGVIYVAVNVAYSIVLSPTEMIASNAVAIDFANKTLGAAAFVVPVMVAILLIGSLNSTMFSASRYLQAVSRQGHIPSAISGIAPNCDSPRVALLVHILIAIAVSFLGDPDKLINYVAFAQWSQRAFTMSALLYLRIRGRPRHPDRIQLPIIMPILFFLVCTSMVVISIIDDFKSSAVGLGILLGGLIIFIIFVWDRALPSSHTFRNATHVINEESTKFMQIIFNVVPERVGDEEMKNAIGGAESESEKVPAYKISPTGNGQFKCTRM
Protein: Histone H3-like centromeric protein CSE4 (CENP-A homolog) (CENPA homolog) (Chromosome segregation protein 4) (P36012)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for functional chromatin architecture at the yeast 2-micron circle partitioning locus and promotes equal plasmid segregation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14581449}. Chromosome, centromere {ECO:0000269|PubMed:14581449}.
Interaction partners:
- Histone H4
- Protein SCM3
- Inner kinetochore subunit OKP1
- Centromere DNA-binding protein complex CBF3 subunit A
- Inner kinetochore subunit CTF19
- Histone H2B.1
- Inner kinetochore subunit AME1
- Histone H2A.1
- Inner kinetochore subunit MCM21
- Inner kinetochore subunit MIF2
Sequence:
MSSKQQWVSSAIQSDSSGRSLSNVNRLAGDQQSINDRALSLLQRTRATKNLFPRREERRRYESSKSDLDIETDYEDQAGNLEIETENEEEAEMETEVPAPVRTHSYALDRYVRQKRREKQRKQSLKRVEKKYTPSELALYEIRKYQRSTDLLISKIPFARLVKEVTDEFTTKDQDLRWQSMAIMALQEASEAYLVGLLEHTNLLALHAKRITIMKKDMQLARRIRGQFI
Protein: Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) (Q9WVI4)
Organism: Rattus norvegicus (Rat)
Function: Has guanylyl cyclase on binding to the beta-1 subunit.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Guanylate cyclase soluble subunit beta-1
- cGMP-dependent protein kinase 2
- Guanylate cyclase soluble subunit beta-2
- Nitric oxide synthase 1
- Inosine triphosphate pyrophosphatase
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
- cGMP-specific 3',5'-cyclic phosphodiesterase
- Guanylate cyclase soluble subunit alpha-1
- Phosphodiesterase
- Molybdenum cofactor biosynthesis protein 1
Sequence:
MSRRKISSESFSSLGSDYLETSPEEEGECPLSKLCWNGSRSPPGPPGSRAAAMAATPVPAASVAAAAAAVAAGSKRAQRRRRVNLDSLGESISLLTAPSPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSSADHSNKEEIEDVSGILRCTANVLGLKFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDGSTPSNYSCLTFLIKECETTQITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLRCDNHKVLKFEDCFEIVSPKVNATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
Protein: Subtilisin-like protease SBT4.12 (EC 3.4.21.-) (Subtilase subfamily 4 member 12) (AtSBT4.12) (Q8L7D2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q84WS0}.
Interaction partners:
- HSR201-like protein
- Putative defensin-like protein 3
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Probable serine/threonine-protein kinase PBL15
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Protein IDA-LIKE 4
- Probable serine/threonine-protein kinase PBL7
- Phosphoglycerate mutase family protein
- Zinc transporter 3
- Glutathione S-transferase T2
Sequence:
MANLAASTCLYSWLLVLLLSSVSAIIDEDTQVYIVYMGSLSSRADYIPTSDHMSILQQVTGESSIEGRLVRSYKRSFNGFAARLTESERTLIAEIEGVVSVFPNKILQLHTTTSWDFMGVKEGKNTKRNLAIESDTIIGVIDTGIWPESKSFSDKGFGPPPKKWKGVCSGGKNFTCNNKLIGARDYTSEGTRDTSGHGTHTASTAAGNAVKDTSFFGIGNGTVRGGVPASRIAAYKVCTDSGCSSEALLSSFDDAIADGVDLITISIGFQFPSIFEDDPIAIGAFHAMAKGILTVSSAGNSGPKPTTVSHVAPWIFTVAASTTNRGFITKVVLGNGKTLAGRSVNAFDMKGKKYPLVYGKSAASSACDAKTAALCAPACLNKSRVKGKILVCGGPSGYKIAKSVGAIAIIDKSPRPDVAFTHHLPASGLKAKDFKSLVSYIESQDSPQAAVLKTETIFNRTSPVIASFSSRGPNTIAVDILKPDITAPGVEILAAFSPNGEPSEDDTRRVKYSVFSGTSMACPHVAGVAAYVKTFYPRWSPSMIQSAIMTTAWPVKAKGRGIASTEFAYGAGHVDPMAALNPGLVYELDKADHIAFLCGMNYTSKTLKIISGDTVKCSKKNKILPRNLNYPSMSAKLSGTDSTFSVTFNRTLTNVGTPNSTYKSKVVAGHGSKLSIKVTPSVLYFKTVNEKQSFSVTVTGSDVDSEVPSSANLIWSDGTHNVRSPIVVYIMVVDEA
Protein: RNA-induced transcriptional silencing complex protein tas3 (RITS protein tas3) (O94687)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Interaction partners:
- Chromo domain-containing protein 1
- Protein argonaute
- Argonaute-binding protein 1
- Protein Dicer
- Argonaute-binding protein 2
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- RNA-dependent RNA polymerase 1
- Poly
- Chromatin-associated protein swi6
- Chromatin modification-related protein rik1
Sequence:
MEKGIKKYLPSLPFLACISDFPENHGTSRRSATVSLERVHELFTEHWLSNLKNRREKRQELAEEAVYCRSEMLSQRKLLAAVDFPQQLKNSPAKAKATHTSSGVTKEVRASKKYTSSNVEFPLVTDGKEKPVKSKQLRKNSVTEFEKPIETKKSKHRKSRNKFLDKSSGSMEIESWDNSTSDSIIESSSRLHESISLRENDIRSSDSKSVGWDDNSTGFRESSKSLDHTDTSMFMELDSNSDPQFRPKYQAKSSWFAPDDPEASWGNLDDGWGETNGSWSSTDDTKHYKNEWAESINLDNFNRPSQQEDYDKPKNTQVSRSSNHHRRYDSYHPDSRSDSYRSKREHYDNRDTGPRSKHLEKSSYVYNQNFEDRTHLSDHGAHFHLGNANDFNMQGSSRKRKASDRQRESRENELPTKKLNASDSHNPLASLTTDKNDLYINWLKSLSFFQTNSSCAEALVKVIPHYHNKLIDFSQVLQLVFSASEKFPIQENQPLPEQLMFLSNLEKQTPFAKAVGSSIYKLVTGKNLSLDFASQILKEASILEHKNEK
Protein: Arg83p (A0A1D8PLL5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MARRKGRTFEGCWTCRSRKVKCDLTKPQCNRCLKSNRICQGYEIRLGWCQPMIYDHNDTTNNDTFKFLNNEEFEKDLDNFQRRNVELVKYPKHMKYETYEQLNYILNQFDNLEMMNHDNMSKNEDKDSENEKEFTIGPFKCIKWKNINTMNFKKTSNKIMKTPQKSQPLIKPQNESVTSNKSRIKTKTKHSTNTINDTKISNLKSNKITNGNINVYSDLLNFAKLTIVGIKGPKYNITDQTIYHIFEPEFFPNVDSDDDWLIDINEYLDQLFQQQQKNLPNLSNGNDGCSGGLIITPLLQKLLNNFINQSNEILNFNRMGFQFNYIDIFIIPFIQRIFGELICWDFNDIKSTQLNKSLLISQHGSTDDNPNDSEEEEEQEEQDDDDDEIGDKNIINIDVIFRNIKLIIVYLVLSLSSFQLSTPINNRFNLDDYLLLSIHLRKLAMKMLNYHLDESDTIIEQLEQEQEKEEQSQNTRWRRNYNLVNDYSCYILLALILQIEIDTYLSIFENYELIYAIGDFIIEKTNPKSKSSSTTTSNTTTPKKKKKLSPLLKLLINIFKIKYIFYESTHSINLFNYQINQQDEEINYRDLNENYDLISTSSLSDNENEEEEEEEEEEEEEEEEEDKRQIKPTIKNLIISNDSITTSYEPMSYTISFNKDNSNSLNNAKTKKQQQKTDKTIKTGKENTTITTTTTVVGGGSGGGKKFIPDDNFTNELDINYIYLMYGIPKSLIDLFYEIIHLTNHKNIFHRRKVFPRNFPKICAEFEDRLINWSIDNDSNWQLIYTPITITTTTNNDGSFLELLRLNIISFHQSLIIYYNQLLKKNCKLKDYQDLIEDNLNNFQKLLSHHKQQSKQKQKQKQKLFFKPLIWILFIIGSSTINPSIQNQIKSIWQSIENDYKFGVANYWRCKQILYEIWNQREINNDNNNNNHNNNKSIIGNLGNQTNNKNDTEGDENLGFMNMIREYGIVLNLG
Protein: Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) (P67965)
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).
Interaction partners:
Sequence:
MNFLLTWIHWGLAALLYLQSAELSKAAPALGDGERKPNEVIKFLEVYERSFCRTIETLVDIFQEYPDEVEYIFRPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIARIKPHQSQHIAHMSFLQHSKCDCRPKKDVKNKQEKKSKRGKGKGQKRKRKKGRYKPPSFHCEPCSERRKHLFVQDPQTCKCSCKFTDSRCKSRQLELNERTCRCEKPRR
Protein: Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] (Q28198)
Organism: Bos taurus (Bovine)
Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Plasminogen activator inhibitor 1
- Annexin A2
- Plasminogen
- Serpin domain-containing protein
- Urokinase plasminogen activator surface receptor
- Uncharacterized protein
- Protein S100-A10
- Alpha-2-antiplasmin
- CD4 molecule
- Tissue factor
Sequence:
MMSAMKTEFLCVLLLCGAVFTSPSQETYRRLRRGARSYKVTCRDGKTQMTYRQHDSWLRPLLRGNQVEHCWCDGGRAQCHSVPVRSCSEPWCFNGGTCRQALYSSDFVCQCPEGFMGKLCEIDATATCYKDQGVAYRGTWSTAESGAECANWNSSGLAMKPYSGRRPNAIRLGLGNHNYCRNPDQDSKPWCYVFKAGKYISEFCSTPACAKVAEEDGDCYTGNGLAYRGTRSHTKSGASCLPWNSVFLTSKIYTAWKSNAPALGLGKHNHCRNPDGDAQPWCHVWKDRQLTWEYCDVPQCVTCGLRQYKRPQFRIKGGLFADITSHPWQAAIFVKNRRSPGERFLCGGILISSCWVLSAAHCFQERYPPHHLKVFLGRTYRLVPGEEEQTFEVEKYIIHKEFDDDTYDNDIALLHLKSDSLTCARESASVRTICLPDASLQLPDWTECELSGYGKHESSSPFFSERLKEAHVRLYPSSRCTSQHLFNRTVTNNMLCAGDTRSGGDHTNLHDACQGDSGGPLVCMKDNHMTLVGIISWGLGCGRKDVPGVYTKVTNYLDWIRDNTRP
Protein: Ran-binding protein 1 homolog c (P92985)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250}.
Interaction partners:
- RAN GTPase-activating protein 1
- GTP-binding nuclear protein Ran-3
- GTP-binding nuclear protein Ran-2
- Nuclear pore complex protein NUP155
- F2O10.4 protein
- Nuclear pore complex protein NUP88
- Nuclear pore complex protein NUP54
- Nuclear pore complex protein NUP107
- mRNA export factor GLE1
- RAN GTPase-activating protein 2
Sequence:
MASTEPERENREDETEVNEDEDTGAQVAPIVRLEEVAVTTGEEDEDAVLDLKSKMYRFDKEGNQWKERGAGTVKLLKHKETGKVRLVMRQSKTLKICANHLISSGMSVQEHSGNEKSCLWHATDFSDGELKDELFCIRFASIENCKTFMEKFTEIAESQQVGKESTQGDEAAGLIENLSVEENISEEKAKEAEEKEPAKEDKETKKEKVEEEKKTEAST
Protein: ABCF1 (A0A1U9X609)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE
Protein: adenylate cyclase (EC 4.6.1.1) (Q8MRM8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINFPMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKLVNRSLSRRFSVMSSLDPDSLRKSSSSDQESGE
Protein: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) (O00425)
Organism: Homo sapiens (Human)
Function: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29476152}. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Interaction partners:
- Insulin-like growth factor 2
- Insulin-like growth factor 2 mRNA-binding protein 1
- Heterogeneous nuclear ribonucleoproteins A2/B1
- High mobility group AT-hook 2
- YTH domain-containing family protein 1
- ELAV-like protein 1
- Insulin-like growth factor 2 mRNA-binding protein 2
- YTH domain-containing family protein 3
- YTH domain-containing protein 1
- YTH domain-containing family protein 2
Sequence:
MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
Protein: Agamous-like MADS-box protein AGL28 (Q9LMM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that may function as a floral promoter operating upstream of known floral activators in the autonomous pathway.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Agamous-like MADS-box protein AGL36
- MADS-box transcription factor PHERES 1
- AGAMOUS-like-34
- MADS-box transcription factor family protein
- MADS-box transcription factor PHERES 2
- Agamous-like MADS-box protein AGL90
- Agamous-like MADS-box protein AGL49
- F-box/kelch-repeat protein At5g03020
- Transport/golgi organization-like protein, putative
- Coatomer subunit zeta-1
Sequence:
MARKNLGRRKIELVKMTNESNLQVTFSKRRSGLFKKGSELCTLCDAEIAIIVFSPSGKAYSFGHPNVNKLLDHSLGRVIRHNNTNFAESRTKLRIQMLNESLTEVMAEKEKEQETKQSIVQNERENKDAEKWWRNSPTELNLAQSTSMKCDLEALKKEVDEKVAQLHHRNLNFYVGSSSNVAAPAAVSGGNISTNHGFFDQNGNSTSAPTLPFGFNVMNRTPAGYNSYQLQNQEVKQVHPQYWARYY
Protein: Gamma carbonic anhydrase 3, mitochondrial (AtCA3) (GAMMA CA3) (EC 4.2.1.-) (Q94AU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide. Mediates complex I assembly in mitochondria and respiration (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15604675}; Peripheral membrane protein {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15604675}; Matrix side {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:15604675}. Note=Probably integral to the membrane. {ECO:0000250}.
Interaction partners:
- Gamma carbonic anhydrase 2, mitochondrial
- 2Fe-2S ferredoxin-like superfamily protein
- Gamma carbonic anhydrase-like 2, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- Gamma carbonic anhydrase 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Acyl carrier protein 1, mitochondrial
- Acyl carrier protein 2, mitochondrial
Sequence:
MGTMGKAFYSVGFWIRETGQALDRLGCRLQGKNHFREQLSRHRTLMNVFDKTPNVDKGAFVAPNASLSGDVHVGRGSSIWYGCVLRGDANSISVGAGTNIQDNALVHVAKTNLSGKVLPTVIGDNVTIGHSAVLHGCTVEDEAYIGTSATVLDGAHVEKHAMVASGALVRQNTRIPSGEVWGGNPAKFLRKVTEEERVFFSSSAVEYSNLAQAHATENAKNLDEAEFKKLLNKKNARDTEYDSVLDDLTLPENVPKAA