wanglab/gogpt-training-data huggingface dataset:
Protein: Isethionate TRAP transporter (Q5LQX4)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- TRAP transporter small permease protein
- Isethionate TRAP transporter
- Isethionate dissimilation regulator
- Isethionate dehydrogenase
Sequence:
MKVSDKLSGVSRRDFFRVAGRFGLSSTVLGLGGLTGAVTLPSLAAAAESTYDKRFKKEAKHTLKFGAAGFNARNLLIERAGCLEFARDLEERTDGEIRVEFIGDNQICGQLSCVEKTQNGIVDIYAASTQNSAGGAPYLNVLDYAYVFPGRASQYHFLYSPESNAILRDPLEKRHGLKFLFSHCELRGLQMGKSFADKPTVTKLEELFGTKNRVTGTQLGRIAMQLLNLNPVPVAWEETLDGLKTGLIDGAETWASAVAYANMSPVVSQSVDLRFFCGTEHTSMSAKVFDSLDGYLQDAVMESAYLAQVHVQAANEAALVKTVGFSDPVLPGTLFDEHDVRPAFLAEDQIKMAEEMCSPEYNPEPWAQWRERLNNWSGGIDTYAELHRVAREVPADMKPENVEPRRWWKG
Protein: Olfactory receptor 10G3 (Olfactory receptor OR14-40) (Q8NGC4)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MERINSTLLTAFILTGIPYPLRLRTLFFVFFFLIYILTQLGNLLILITVWADPRLHARPMYIFLGVLSVIDMSISSIIVPRLMMNFTLGVKPIPFGGCVAQLYFYHFLGSTQCFLYTLMAYDRYLAICQPLRYPVLMTAKLSALLVAGAWMAGSIHGALQAILTFRLPYCGPNQVDYFFCDIPAVLRLACADTTVNELVTFVDIGVVVASCFSLILLSYIQIIQAILRIHTADGRRRAFSTCGAHVTVVTVYYVPCAFIYLRPETNSPLDGAAALVPTAITPFLNPLIYTLRNQEVKLALKRMLRSPRTPSEV
Protein: RH13728p (Q8SXG0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGRVPAKMHTLLALLLQLLVASIHAIEWSLPDVVNSIGNVGTSIVDPSLLPTPQGLLEGSKQLIAGYPFEFVSNSLNVICSQALASNKIKSKYSPDINKMNFQLQTACEKKNFPLTSPESMWKSPLFDVKKKVVILATGWTTTVNGSDTIEVFSKAYNCRGDVNFVAVDAARFVDTLYTWSAFNTEEIGENIALGLVKLLDLVPVENIHLIGHSLGAHIVGSAGRHLQHLTNQTIPRITGLDPAKPCFNEGEALSGLMRGDAHFVDVIHSNPGVLGKRDPVGDVDFYPGGMSPLAAGCFSVTCAHARSWEYFAETVFPGNERNFMATRCNSISKLRDFRCPGDEVPMGYAVPQNIKGNYFLEVSASAPFGMHASVVRSAHLEHCGLCPESTSTTEVPSTTTTGKPGSWFSG
Protein: Claudin-9 (O95484)
Organism: Homo sapiens (Human)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell junction, tight junction. Cell membrane {ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:31175426}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tight junction protein 1
- Claudin-6
- Occludin
- Tight junction protein ZO-3
- Claudin-12
- Claudin-1
- Claudin-14
- Claudin-16
- Claudin-8
- Claudin-10
Sequence:
MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV
Protein: C-type lectin domain family 2 member I (C-type lectin-related protein DCL1) (C-type lectin-related protein G) (Clr-g) (Lymphoid-derived C-type lectin-1) (LCL-1) (Osteoclast inhibitory lectin-related protein 2) (Ocil-related protein 2) (Q9WVF9)
Organism: Mus musculus (Mouse)
Function: Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Killer cell lectin-like receptor subfamily B member 1F
Sequence:
MPDCLETGEKLFVHNMNAQCVQKPEEGNGPLGTGGKIVQGKCFRIISTVSPVKLYCCYGVIMVLTVAVIALSVALSTKKTEQIIINKTYAACSKNWTGVGNKCFYFSGYPRNWTFAQAFCMAQEAQLARFDNEEELIFLKRFKGDFDCWIGLHRESSEHPWKWTNNTEYNNMNPILGVGRYAYLSSDRISSSRSYINRMWICSKLNNYNLHCQTPPV
Protein: Sigma-E factor regulatory protein RseB (P0AFX9)
Organism: Escherichia coli (strain K12)
Function: Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS).
Subcellular location: Periplasm {ECO:0000269|PubMed:11777003, ECO:0000269|PubMed:9159522, ECO:0000269|PubMed:9159523}. Note=Partially associates with the inner membrane via RseA.
Interaction partners:
- Protein RseC
- Anti-sigma-E factor RseA
- ECF RNA polymerase sigma-E factor
- Regulator of sigma-E protease RseP
- Serine endoprotease DegS
- Uncharacterized protein YafS
- Negative modulator of initiation of replication
- Lipopolysaccharide export system protein LptC
Sequence:
MKQLWFAMSLVTGSLLFSANASATPASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSMQTLAKANLPPLLSVPVGEKAKFSWTPTWLPQGFSEVSSSRRPLPTMDNMPIESRLYSDGLFSFSVNVNRATPSSTDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAENIKFGAAQ
Protein: Acetate CoA-transferase subunit beta (EC 2.8.3.8) (Acetoacetyl-CoA transferase subunit beta) (AA-CoA transferase subunit beta) (Acetyl-CoA:acetoacetate CoA-transferase subunit beta) (P76459)
Organism: Escherichia coli (strain K12)
Function: Coenzyme A transferase which is involved in short-chain fatty acid degradation and catalyzes the activation of short-chain fatty acids to their respective CoA thiolesters. During acetoacetate degradation, catalyzes the transfer of CoA from acetyl-CoA to acetoacetate by a mechanism involving a covalent enzyme-CoA compound as a reaction intermediate. Utilizes a variety of short chain acyl-CoA and carboxylic acid substrates but exhibits maximal activity with normal and 3-keto substrates.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1103739}. Note=Membrane associated. {ECO:0000269|PubMed:1103739}.
Interaction partners:
- Acetate CoA-transferase subunit alpha
- Acetyl-CoA acetyltransferase
- Putative short-chain fatty acid transporter
- Fatty acid oxidation complex subunit alpha
- Acetate CoA-transferase YdiF
- Fatty acid oxidation complex subunit alpha
- Bifunctional aldehyde-alcohol dehydrogenase AdhE
- Probable acetyl-CoA acetyltransferase
- Acetaldehyde dehydrogenase
- Regulatory protein AtoC
Sequence:
MDAKQRIARRVAQELRDGDIVNLGIGLPTMVANYLPEGIHITLQSENGFLGLGPVTTAHPDLVNAGGQPCGVLPGAAMFDSAMSFALIRGGHIDACVLGGLQVDEEANLANWVVPGKMVPGMGGAMDLVTGSRKVIIAMEHCAKDGSAKILRRCTMPLTAQHAVHMLVTELAVFRFIDGKMWLTEIADGCDLATVRAKTEARFEVAADLNTQRGDL
Protein: Heat shock protein HslJ (P52644)
Organism: Escherichia coli (strain K12)
Interaction partners:
Sequence:
MKKVAAFVALSLLMAGCVSNDKIAVTPEQLQHHRFVLESVNGKPVTSDKNPPEISFGEKMMISGSMCNRFSGEGKLSNGELTAKGLAMTRMMCANPQLNELDNTISEMLKEGAQVDLTANQLTLATAKQTLTYKLADLMN
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (Q541Z2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHCRESDIPASV
Protein: Grip2 protein (Q499W6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
EAVRIQRSEQLHRWDPSAPSCHSPRPSHCRAPTWAAGGPDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEDAVQILRQCEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPPEALKGGLLATRFSPAVPSVDSAVESWGSSATDGGFGGTGSYTPQVAVRSVTPQEWRPSRLKSSPPPLEPRRTSYTPGPSDESFPEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTGTVHSVAVDGRPGSRPWRRSREVRTSPEDLQELLLPTPL
Protein: B-cell lymphoma 6 protein homolog (P41183)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:9927193}.
Interaction partners:
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- BCL-6 corepressor
- Histone deacetylase 5
- Histone deacetylase 4
- T-box transcription factor TBX21
- Paired amphipathic helix protein Sin3a
- Interferon regulatory factor 4
- C-X-C chemokine receptor type 5
- Forkhead box protein P3
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEISPEGFCILLDFMYTSRLNLREGNIMAVMTTAMYLQMEHVVDTCRKFIKASEAEMAPALKPPREEFLNSRMLMPHDIMAYRGREVVENNMPLRNTPGCESRAFAPPLYSGLSTPPASYPMYSHLPLSTFLFSDEELRDAPRMPVANPFPKERALPCDSARQVPNEYSRPAMEVSPSLCHSNIYSPKEAVPEEARSDIHYSVPEGPKPAVPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGSEQAELGRLSPRAYPAPPACQPPMEPANLDLQSPTKLSASGEDSTIPQASRLNNLVNRSLAGSPRSSSESHSPLYMHPPKCTSCGSQSPQHTEMCLHTAGPTFPEEMGETQSEYSDSSCENGTFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSAADLPPELPKAC
Protein: WW domain binding protein 2 (cDNA FLJ59459, highly similar to WW domain-binding protein 2) (A6NG10)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANYIKGTVKAEAGGGWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPSGAYGYSYMPSGAYVYPPPVANGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPDVPSTPAAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ
Protein: Ran-specific GTPase-activating protein (HpaII tiny fragments locus 9a protein) (Ran-binding protein 1) (RANBP1) (P34022)
Organism: Mus musculus (Mouse)
Function: Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity).
Interaction partners:
- Ran GTPase-activating protein 1
- GTP-binding nuclear protein Ran
- Exportin-1
- Regulator of chromosome condensation
- Peptidyl-prolyl cis-trans isomerase A
- Importin subunit beta-1
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Peptidyl-prolyl cis-trans isomerase H
- Peptidyl-prolyl cis-trans isomerase
- Nuclear pore complex protein Nup214
Sequence:
MAAAKDSHEDHDTSTENADESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKGPGKNDNAEKVAEKLEALSVREAREEAEEKSEEKQ
Protein: Putative antitoxin VapB49 (P9WF15)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential).
Interaction partners:
- Ribonuclease VapC49
- Ribonuclease VapC9
- Putative antitoxin HigA3
- Putative antitoxin VapB45
- Putative toxin HigB3
- Ribonuclease VapC47
Sequence:
MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRRRCRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLAALDSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR
Protein: [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) (C9WPN3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPVKFDILRISGNEEKKMAAEKARGEGEEGSFSLTVEEKKALCGLDSSFFGFLSLCKDGVKMKTLLNKAIHCYESLIVKAEGKVESDFFCQLGHFNLLLEDYSKALSSYQRYYSLQTDYWKNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNFCRAKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNVCTLSSVEIQFHIAHLYEIQRKYHSAKAAYEQLLQIESLPSQVKATVLQQLGWMHHNMDLVGDNTTKERYAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKSCSNTSVLISRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNVSDSWNSVHTASHHPVQQQVYTQCFTTQKLQGLGKDQQRPFQTGSTRYIHAACVDNQNQNGNHTLPQNSKGDTQNHSSLHIPTSEEQKIFNFTKESKDSRSKSLSPKTSRQDRDTSNIYVNAKEHSKNIHEITSVPISSLNNEDSVSPNLIIVDNPQLSVLVGEAMDSVDHDSRTCDKVNNVHPTLHKKPDNLTASSPSSASSTETLSLKVTEQMHTHIVTSFISPNSGLDTINGGPENSESSISVSVGLRPRPQIIPSMSVSIYSSSTEVLKACRNLGKNGLPNGHILLDICPPPRPPTSPYPPLPKEKLNPPTPSIYLENKRDAFFPPLHQFCINPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHIVEVRTQFLQPADENWDPSGTKKIWRYENKSSHTTIAKYAQYQACSFQESLREENERKTQVKDYSDNESTCSDISRRRQKVPFKTIKCGINIDLSDNKKWKLQLHELTKLPAFVRVVSAGNLLSHVGYTILGMNSVQLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNVGPLTAFQYKLAVERYEWNKLQSIKSVVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQCQTLREALVAAGKEVLWHGR
Protein: Heat shock factor protein (HSF) (Heat shock transcription factor) (HSTF) (Q02953)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Heat shock protein 90 homolog
- Probable heat shock protein ssa2
- Transcription factor prr1
- Heat shock protein 104
- Probable heat shock protein ssa1
- Mitogen-activated protein kinase spk1
- Ribosome-associated molecular chaperone sks2
- Hsp70 nucleotide exchange factor fes1
- NAD-dependent histone deacetylase sir2
- Mitogen-activated protein kinase sty1
Sequence:
MIQTASTISSNGGTNQGMESSSANSPEMNGTQNSMSVGMSGSGSSQNRKITQFSNKLYNMVNDSSTDSLIRWSDRGDSFLVIGHEDFAKLVLPRYFKHNNFSSFVRQLNMYGFHKVPHIQQGVLQSDSPNELLEFANPNFQRDQPELLCLVTRKKAGSQPVEESNTSLDMSTISSELQNIRIQQMNLSNELSRIQVDNAALWQENMENRERQRRHQETIDKILRFLASVYLDGKQKPPSKVMPKSRRLLLEAKYPTVSPTNEPSAHSRPSPQGTTANSSSASISSLHNTTPDGEGKYRSVQNGRALNYVSSFNSDSHSPKDYISQSYTNEPGLKKESADSFNNSIDSYISPNQSPNTDVPSLNRDDTTDPKVVNTGDIINMLDDANSIEGSNMNSLSPLLFDYPNSLYPVNNTSSEQHHNSYRGSVSNSQPSGNLSESTNLQPVQPVDYMSNSNPSYGSYNAEDQLTNFHPGYAMDQKRISKLSDGITKQDQNIQALADILGIPLGDGKIDDAGFSANSPTNLNLPVSSDLDSVLNIPPNEDVFPDSNPVFDEFTNISNLTSPIEASNGNTFGSNPVSLPNQQKSVNPSLMTVSSPRQVRKKRKSSIGA
Protein: DASH complex subunit DAD5 (High osmolarity sensitivity protein 3) (O94483)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in the progression of mitosis in an environment of high osmotic stress.
Subcellular location: Nucleus {ECO:0000305|PubMed:16079914}. Cytoplasm, cytoskeleton, spindle {ECO:0000305|PubMed:16079914}. Chromosome, centromere, kinetochore {ECO:0000305|PubMed:16079914}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:20624975}. Note=Associates with the mitotic spindle and the kinetochore. In the cytoskeleton, localizes to cortical microtubules. {ECO:0000305|PubMed:20624975}.
Interaction partners:
- DASH complex subunit duo1
- DASH complex subunit dad2
- DASH complex subunit spc19
- DASH complex subunit dad3
- DASH complex subunit ask1
- DASH complex subunit spc34
- Microtubule protein alp7
- Spindle pole body component alp14
- DASH complex subunit dad4
- DASH complex subunit dam1
Sequence:
MRRSTIVPTSRTSSSSPSPSQMKSFQMNRLVDQLSKLQSNMSHLENHLHVTAIQAEAIRRLGALQASLLMASGRVMSEARIQKSSDAVEEDVPM
Protein: Otospiralin (Q8K560)
Organism: Rattus norvegicus (Rat)
Function: May be essential for the survival of the neurosensory epithelium of the inner ear.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Otoancorin
Sequence:
MQPCVLWWLALGLLLGIPAGAKPTPEEADPNAQPPAMPYWPFSTSDFWNYVQYFQSQGAYPQIEDMARTFFAHFPLGSTLGFHVPYQED
Protein: N-acetylgalactosamine permease IIC component 1 (EIIC-Aga) (PTS system N-acetylgalactosamine-specific EIIC component 1) (P42910)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- N-acetylgalactosamine permease IID component
- N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1
- PTS system mannose-specific EIID component
- Putative deaminase AgaI
- Putative D-galactosamine-6-phosphate deaminase AgaS
- Phosphocarrier protein HPr
- PTS system mannose-specific EIIAB component
- N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2
- D-tagatose-1,6-bisphosphate aldolase subunit KbaY
- Putative phosphotransferase enzyme IIA component YadI
Sequence:
MHEITLLQGLSLAALVFVLGIDFWLEALFLFRPIIVCTLTGAILGDIQTGLITGGLTELAFAGLTPAGGVQPPNPIMAGLMTTVIAWSTGVDAKTAIGLGLPFSLLMQYVILFFYSAFSLFMTKADKCAKEADTAAFSRLNWTTMLIVASAYAVIAFLCTYLAQGAMQALVKAMPAWLTHGFEVAGGILPAVGFGLLLRVMFKAQYIPYLIAGFLFVCYIQVSNLLPVAVLGAGFAVYEFFNAKSRQQAQPQPVASKNEEEDYSNGI
Protein: Granulin b (F1R6I2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- TAR DNA-binding protein 43
- Guanine nucleotide exchange C9orf72 homolog
- Sortilin
- Charged multivesicular body protein 2b
- Charged multivesicular body protein 2Ba
- Sortilin.
- Sortilin
- Heparan sulfate proteoglycan 2.
Sequence:
MVRAAFIALLCVCVNACTALICPDGGMCEDGNTCCLTPSGGYGCCPLPHAECCSDHLHCCYQGTLCDLEHSKCVNKTHVLDWVEKVEAKLQAVVCPDGESECPDDTTCCQMPDGGWGCCPMKNAVCCDDRKHCCPQGTTCDLVHSMCVSTTYGSSPFLRKFDARRRKPLEKNAVDLPAEVNNIREVICPDKISKCPEDTTCCLLETGSYGCCPMPKAVCCSDQKHCCPEGTTCDLIHSTCLSANGVSEMATKIPAVTVLKPKEEVVPCNETVACSSGTTCCKTPEGSWACCPLPKAVCCEDHIHCCPEGTLCNVAASSCDDPAGLSVSVPWMEKVSTKPIAPPPNKKCDESSSCPGESTCCKLSSGDWGCCPLPEAVCCEDHVHCCPHGSVCNVAAETCETVSDSGLRISVPMVKKIPAVSVPSQKQNCDETSSCPTGTTCCKLTSGSWACCPMPQAVCCADQEHCCPQGYTCDLAQSSCVRSGLPSMAWFRKEPALRETQRVEDRHMCDAQTSCPRDDTCCFINRIGKWGCCPLPKAVCCKDGDHCCPSGYTCNEEKTSCTKGLHQIPWFTKKTARVWKSSDELLGHEDVKCDSSTSCPSGSTCCILPTGQWGCCPLVKAVCCEDHEHCCPQGYICKLELGTCEKASADVSVSLTAVQMPEIQCDTFTRCAHTQSCCRLADSTWACCPYTQAVCCKDMKHCCPMGYKCDPKVQGCTKSSSSTWWNNSL
Protein: LOC567411 protein (A3KPA9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
EQHKTHVQQVTLKLEHFRTDLSVGAVMSVSLWCEEDSGRDRTHQASVRAPWDPSASGQRVIQRLLQSEERYLPSSLYISLVQREPQRREELAKWTMEVCCECDCDESVFPLAVSLLDRYLSATLSLPVSPSCLAAACILLASKVTESDTVSADTLCAAAEYDFLSANLREMERVVLATLRWDVLAVTPQDFIPLFLRTLGELRDGDGHTGDFLTTMRRHGDTLVAMCVCDSRFLGTPPSLVAAAALNSALRGLRARSAGEMSLMTAALATLCQTDVALLQCCTELIDGALRERLRTGAQEQKDGDIEEEERASTPTDLREIDF
Protein: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (Q9Y233)
Organism: Homo sapiens (Human)
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10441464}.
Interaction partners:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenosine kinase
- GMP reductase 1
- Adenine phosphoribosyltransferase
- Guanylate kinase
- Hypoxanthine-guanine phosphoribosyltransferase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Deoxycytidine kinase
- Inosine triphosphate pyrophosphatase
Sequence:
MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAERAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWPPPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSSHRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGGGGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Protein: tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) (Q72DL8)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Interaction partners:
- Large ribosomal subunit protein bL17
- DNA-directed RNA polymerase subunit alpha
- tRNA pseudouridine synthase B
- Conserved domain protein
- Ribosomal RNA small subunit methyltransferase H
- Anthranilate phosphoribosyltransferase
- Pantothenate synthetase
- Ornithine carbamoyltransferase
- Endoribonuclease YbeY
- Conserved domain protein
Sequence:
MARLRLTIAYKGTDLHGWQVQEHATRPRPRTVQGVLEPIVSRMAGEQVRLHAAGRTDAGVHADGQVAHVDIPDHKLGVDWQKAINAQLPDDICILDVRRAADDFHARFDALGKRYTYRLWLTRRFIPPKLHGQVWATGPLDVYAMDRAARHLAGTHDFAAFQNQGTDVTSTVRTVHAIRRCPSGTLPAGALLTCSEPYTSWRCTGTHPDQPPATAGHPLAGIGLELVWSFEGDGFLKQMVRNMMGLLVAVGRGALAADDVPGIMATLDRSRAPATAPACGLTLSEVYYPPCDYPYAR