wanglab/gogpt-training-data huggingface dataset:
Protein: ABC transporter C family member 8 (ABC transporter ABCC.8) (Q54P13)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MGFCGDEPFTVWHNDSGDFSKCFEDSVVMTLPAIYLLIFGMKRLYYLENKKPDLFTLKQLSQDFQTWRKTLQLEVIVSILLVAWKILFFIVIVSIYNKPFEILYSVVTVVQWTVSLGLVYLEMKKGQSRSWEIRLYWVFAFFVATVKLRTLTLAIAGKSIYNVGFLEYFSYFVGYCLILILSITSVLFFDNLESYQNLEENEISKEVNANLFSRLTFWWINSVLVKGHKKALEISDVPTLGEIDQSILLSEKFEKAWEEQLKKPNPSLPWALAKAFGPHFYIAALFKIIQDLLIFVGPTLLKRVLGFVESRDGSQDTYDGLIYALLYFLAPVVQSLLLHQYFHRCYRVGMWLRSAVVTAVYKKALKTSLREGTTIGEIVNLMSVDAQKFMDLCPYLHMIWSAPLQLAISLVLLYRILNASVFAGLGIMLVMIPINLAISNLAKKRQTISMKLKDRRTKAVNEVLNGIKVIKLYSWEQSFMDHVNEIRNKELDVMKAIKYIQGFSLLLWSMSPVFVSVSTFTVYILTGQVLSATQAFPALSLFNVMQFPINMLPSVVSSIIEASVSVARLQKFLLKKDLDPNVVEHHINEPGIAVKIDNATLEWEPNKPILHDINLTIKKGELVAIVGQVGSGKSSIVSSLVGDLDKTKGTVAVNGSVALVSQQAWIQNATLKNNILFAKELNQDKYQSVVQACCLEPDIKILPGGDQTEIGEKGINLSGGQKQRVSIARAVYNNADIYIFDDPLSAVDAHVGKAIFKNVLSNQDGILCNKTRILVTHAVHYLPYVDRIILMKDGRIVEEGDFNTLIEAGSHFTELMSHDEQQQQLQQQQAPDKSSDSNEQIGGGDNKESENNEEQNEEEEGENENLLEKVLRKSRSRSPSPSSNRNIDGDDIASGSILQTTRTPEEDEQDERELMEDIDIDGGENIQTPLQKGEKSSVLKQPLRLLKKLPTSINKKLNNSGSGVSLKPITTVNAKPQDKNKIISVETKQEGKVSFKIYLSYFKAIGVLLATCIIGFYVLTQLLSILANWWISIWTNSYGGNGNGSGSGSISLSSSSTVEDNEKAKYYLSIYVAFSCGTIAATFLRSFSMVFGSIKGSKLFHEKMFKAVILSPMSFFDTTPIGRILNRFSKDQLTIDESIARTLGMFLNTFCQVVGSIIVIAWVSPFIILAMVPVGALFYFIQKYYLNSSRELTRLEGVSRSPIYAHFSETLAGVTTIRAFKDVARFVTENERLLDENQKCYYINISSNRWLAIRLEFLGACLVSCAVLYTVLARSRIEAGTAGLVITYALAITGNMNWMVRMSCDLENSVVSIERIQEYCLLPSEAPLFNDKSVPMSWPSHGKIVFKNLWLTYREGLDPVLRGINCTIEPKTKVGIVGRTGAGKSSLTQALFRLVEPLRGTIEIDGIDITELGLNPLRSRMAIIPQDPVLFAGSVRYNLDPFDQYDDHEIWEAIENAHLLKAIKDLDGGLDAMVQDGGDNFSVGQRQLLVIGRALLKKANIIVLDEASSSIDIASDALIQETIRTKFADCTVLTIAHRLGTIADSDKIMVLDKGELIEYDSPSELLKNQDSIYYSLVKASESKQNIDNDDESN
Protein: Dual specificity protein kinase pyk3 (EC 2.7.12.1) (Tyrosine-protein kinase 3) (Q54I36)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the development. Negatively regulates tyrosine phosphorylation and activation state of dstC/STATc, probably by activating a dstC/STATc phosphatase.
Interaction partners:
- Signal transducer and activator of transcription C
- Tyrosine-protein phosphatase 3
- Cyclin domain-containing protein
- SrfA-induced gene G protein
Sequence:
MDSFNNNNNNNNNNNNNNNNINGEGITLRTLLNSCTNTSSNEQLIVNNVNKNSNIINNININNTPSPISTCINVNKIELRGSSNGIFLNSKIKVPLPNSTLLEQQQDGADEQDKKQQSLSDKNILFSSGDKEFLNHGSNNIITDQNTLLYQLQQQQQKEKEKENDEIMNHDDIIGYNEENEDNFFNEGMDPILAHSIEHHLHNHHHHHGEFDTQENEDTSGESSDESENIDEVLVYTEDIESEKEKKRERLITSPPSFDPHTLYSMSQSLLNCSLNNNNNNNNSISSPSSSINNSGNNINLNNSGNNNVNSNNNTNIINNSNDNFISQPLFNPLSMPNNEQYELLPNPTTTTSTITSTTTTTTITNLPPALPSFPSSSSIKSLKNSFGSNSITSSGELNNVFSSSMSPPMSPPNRNVRSLTFPGTNPINCINTSVINSITANTNCINHHHHHHQHNHHNHHQGHNNINNSGHIRKSADDTVTLSPTLSSGSSSTSSSNPHHPNHNHQKGLNNKTLEKLSCTRKEIYELIEKKESLIEKQNLIDEGYSENADSFENLSEEIQKINEKIIELENLITSLSNSNSNWSLNGSSTSTISCNPLSPRSMNPSSSTSSTSSNLTNSLRKFSQELKIELRPLDLRAELYSSINTSPRGSASISGGSGSGGGGNNNGCFKTSSNSSINSPIQFFENENESIDSYEKKNEEQFESLTQLIRENQLYTKPIEFKEIKLLEKLESNSKSSNIWQIEYKSTQLVLKQPKDQDSDKNIEKRKQLFNGSNVSGSNNSGSSGGNNHNHHHCNNSNGSNSEVIPSKYTMIQHKNLGLLVGWCGDSIIFESFKGMNSLHDLIHRDGLKIDMALFIKISKDIASVMGLLHSKDVAHGNLTSRSIYLDRFQIVKVSFPKLNATDLNNPAIEPRYMAPEMTRMEEDQISCSIDVYAYAFVLWEALTSHLPFRKFNDISVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLFDHLEGKLFFSSPGILWSLNNDQEVERELQKKERFNEITEFLRGKKEIKFDEVAIVEKVGAGSFANVFLGIWNGYKVAIKILKNESISNDEKFIKEVSSLIKSHHPNVVTFMGACIDPPCIFTEYLQGGSLYDVLHIQKIKLNPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGITNPRWRSPELTKGLVYNEKVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTELETMKSKFIKQLSFLNDLIQNPDDDYNNNLNYDEEVDS
Protein: Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230) (P04156)
Organism: Homo sapiens (Human)
Function: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19936054}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000269|PubMed:19936054}.
Interaction partners:
- Amyloid-beta precursor protein
- Stress-induced-phosphoprotein 1
- Neural cell adhesion molecule 1
- Tyrosine-protein kinase Fyn
- Caveolin-1
- Alpha-synuclein
- Endoplasmic reticulum chaperone BiP
- Prion-like protein doppel
- Metabotropic glutamate receptor 5
- Small ribosomal subunit protein uS2
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
Protein: Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) (O44334)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDIGTIELSVEALIGSLLALSILFAFCRSLLSEDFVSTFKTRHSWKSIKVLEQACFCNVCEILLTPSAGLFCDCCGLCTHATPPCQRRADREYRCKDKWLRNESSVRHLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACDLGEFKDMIFPPYSFVAARTRDSMRLHLASITPPDIENWEPLIVIANTKSGSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTLNIKPQPSVAIMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLHYRLPIQRHPTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTLYLDNKPVQLPELQALVFLNIDSWGAGCNVCELSNANGEVRIVNSISDGMMEVFGIVSSFHIAQLQCNISKPVRIGQAKQIRLQVKETVPMQADGEPWMQSPADIRLSSRSQARVLKLAAT
Protein: Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) (O75676)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Subcellular location: Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}.
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 11
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 12
- Ribosomal protein S6 kinase alpha-5
- Cyclic AMP-dependent transcription factor ATF-4
- Cyclic AMP-responsive element-binding protein 1
- Cyclic AMP-dependent transcription factor ATF-2
- Cyclic AMP-dependent transcription factor ATF-6 beta
Sequence:
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Protein: Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC) (Q64GA5)
Organism: Mus musculus (Mouse)
Function: Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at the sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:15950603}. Nucleus envelope {ECO:0000269|PubMed:15950603}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15950603}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15950603}. Note=In germinal vesicle stage oocytes and early embryos, shows mainly uniform nuclear and cortical expression. During germinal vesicle breakdown, found in intensely stained foci which accumulate near the dissolving nuclear envelope. Also localizes to spindle poles at metaphase II. {ECO:0000269|PubMed:15950603}.
Interaction partners:
- Polyunsaturated fatty acid 5-lipoxygenase
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Phospholipase A and acyltransferase 3
- Mitogen-activated protein kinase 3
- Arachidonate 12-lipoxygenase, 12R-type
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Mitogen-activated protein kinase 1
- Protein kinase C alpha type
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Sequence:
MELSSGVCPATRLQEAEKAAVHKRSPKVLEALRKLNIQADQAPVIAVLGSGGGLRAHIACLGVLSELKELGLLDAVTYLAGVSGSTWALSSLYTKNGNMEGIEEELKHRYEKNEWDFHESLEKAIQASKRENYSLTDFWAYLIVSRQIRELQDSNLSSLKKQVEEGVLPYPIFAAIDEDLLADWRERKTQNSWFEFTPHHAGYPALGAYVPITEFGSRFENGKLVKSEPERDLTFLRGLWGSAFADIKEIKNYILNYFRNPFGKLKFIEGPVTYSEAPRMNVDAMLLDLVMAYFTDMNDPSIKDKLCALQQALGTETDEFGIEMAEIIQNWNETSAEKKEQFLDHLLDRFKKTQEDTTTYSLMNWNTGLVWDRCVFVNETRKCVSKWQWGTVYNFLYKHGKIADETMCSRELLHLVDAGFAINTPYPLVLPPVRETHLILSFDFSAGDPLETIRATADYCQRHEIPFPEVSEDQLKEWAKAPASCYVLRGETGPVVMHFTLFNKDNCGDDIETWRKKYGTVKLSDSYTPDLVRDLLRVSKENVKKNKINILSEMRKVAGNPGNIPRVNKEACLGDRVKDPQGSQTVEFKKSHNISKD
Protein: Cyclin dependent kinase 2 associated protein 1 (F5GZF0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRG
Protein: steroid 11beta-monooxygenase (EC 1.14.15.4) (Q3TG86)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- Steroid 21-hydroxylase
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- 11-beta-hydroxysteroid dehydrogenase 1
- 11-beta-hydroxysteroid dehydrogenase type 2
- 17-beta-hydroxysteroid dehydrogenase type 3
- Steroid 17-alpha-hydroxylase/17,20 lyase
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- Aromatase
Sequence:
MTMALRVTTDVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSVGKTQIVFVTLPEDVEKLYQVESTHPCRMPLESWIVHRELRGLGRGVFLLNGPEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESVHGSFSMDFQSSVFNYTIEASHFVLFGERLGLIGRDLSPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWDFISEYVTKCIKNVYRELAEGRPQSWSVTAELVAERTLSMDAIQANSMELIAGSTDTTSTPLVMTFFELARNPDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGTFLERILSSDLVLQNYHVPAGTVLNVNLYSMGRNPAVFPRPERYMPQRWLERKRSFKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLMPSSSPLLTFRPVN
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FN27)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome I complete sequence
- Inositol-3-phosphate synthase
- Candida glabrata strain CBS138 chromosome B complete sequence
Sequence:
MDTRRGWIHNYISFSGLSEEDVEAAEALDVLRNSHVDADVEVEEDRSKKRVRDGEDEDGGHVRRRKASVRDRSDSRMSQLSNVSNASTEERVVRVNSHEDSQSKRQEEESLFDKVCRNSNEILTNMGSFFEEMNSNVFMEGGSDVPEEHPNGYVRPRRDSRSISTTGADADTESQGTQGSYNGKWDTWSSRSYNDRQYYSKRKALSEALAKGRYNLREYKLTMSIESKKRLITCLHLLKLANKQLSDKVAYLQDAVEKEQELANGEEVKKETRALNGEHSGPQNDDDLEFYDASESVDQNSGDLGLEIVGTVKKVYSLISKYTGSSLPEPARSQVRESLLNLPSNWNTSVHNGFKNNGTGIMTASSSTDSLSSYSSILPVSSNGKYLILAKESLNMVQSVIDVVDSTLGRAEEWVKQKQELKEMIKKKFLEQQEHQKMLGIGTESLDQNESSVKKEQPTTHISISSITNSTNTLDTVKEEDMHLQKV
Protein: CUB_2 domain-containing protein (Q9TXK1)
Organism: Caenorhabditis elegans
Interaction partners:
- Nuclear receptor domain-containing protein
- CC domain-containing protein
- F-box domain-containing protein
- Uncharacterized protein T25D10.1
- F-box domain-containing protein
- tRNA
- Serpentine Receptor, class Z
- ShKT domain-containing protein
- CUB-like domain-containing protein
- Cytochrome b561 domain-containing protein
Sequence:
MLISISLLLTFCKLSLAQQVIPLNTLIGNNFENKIDVTPPFSLYVSAQMDSDFNLNNIYVKTMDNQIKSLKDLRHSRQHAESGPISPFQATSQTLITTNLSNGTLALMNGFIYVTTSKQSTDQSFRVYSVDNINTIKINGNVDGNCTIVFLNTDSRILPAHSSLFTKWQQPRDATVKMYKGYPTDVLEKNSTQIFSNPVLATGKLLYIPTVETFAVTLGIFYMKTTNDVYFQVDSRNIDFNGYSTQNYQTTGFFMKSKEVVGHNVTINCLRDTRFNGTTGANIMGYMPTKYGKVTVQTNDNTFADSFTVTPVDGILGGSVDKIGKNMTISSVDTDGGEFFVQYYVVQGEQISSTYAPGEPTPPTYESTTKGVKNSKLMLVVGILFLSILSL
Protein: PTS system N,N'-diacetylchitobiose-specific EIIC component (EIIC-Chb) (IIcel) (N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIC component) (P17334)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2). Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3).
Subcellular location: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00428}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00428}.
Interaction partners:
- PTS system N,N'-diacetylchitobiose-specific EIIB component
- PTS system N,N'-diacetylchitobiose-specific EIIA component
- 6-phospho-beta-glucosidase
- HTH-type transcriptional regulator ChbR
- 6-phospho-beta-glucosidase BglA
- 6-phospho-beta-glucosidase AscB
- Chitooligosaccharide deacetylase ChbG
- 6-phospho-beta-glucosidase BglB
- Phosphocarrier protein HPr
- Endoglucanase
Sequence:
MSNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSFFYSLGIRLDASTIETLNGLKGIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLLSVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVAEMFTFIVRRNWVIKLPDSVPASVSRSFSALIPGFIILSVMGIIAWALNTWGTNFHQIIMDTISTPLASLGSVVGWAYVIFVPLLWFFGIHGALALTALDNGIMTPWALENIATYQQYGSVEAALAAGKTFHIWAKPMLDSFIFLGGSGATLGLILAIFIASRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIPFVLVQPILAAITLAAYYMGIIPPVTNIAPWTMPTGLGAFFNTNGSVAALLVALFNLGIATLIYLPFVVVANKAQNAIDKEESEEDIANALKF
Protein: TBC1 domain family member 13 (Q8R3D1)
Organism: Mus musculus (Mouse)
Function: Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
Subcellular location: Membrane {ECO:0000269|PubMed:22762500}. Cytoplasm {ECO:0000269|PubMed:22762500}.
Interaction partners:
- Carabin
- TBC1 domain family member 10B
- TBC1 domain family member 21
Sequence:
MSSLHKSRIADFQDVLKEPSIVLEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWTSILAKQRGLYSQFLREMIIQPGIAKANMGVFREDVTFEDHPLNPNPDSRWNTYFKDNEVLLQIDKDVRRLCPDISFFQRATEYPCLLILDPQNEFETLRKRVEQTTLKSQTVARNRSGVTNMSSPHKNSAPSALNEYEVLPNGCEAHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQSIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADGNRFDFLLLVCCAMLILIREQLLEGDFTVNMRLLQDYPITDVCQILQKAKELQDSK
Protein: SET and MYND domain containing, class 4, member 3 (A1Z8L3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- AT24727p
- GEO11132p1
- Integumentary mucin C.1-like
- FI01104p
- SET and MYND domain containing, arthropod-specific, member 4, isoform A
- GH11294p
- SET and MYND domain containing, arthropod-specific, member 6
Sequence:
MKTPLSQKTGFFAEYYLKLKDQAGPNCESDIAKLSACKSDEERVAYVEKLPWVQAGDANLVVNQEFAGKNASLAAEIKERATSAFKAKKWLEAMMLYTRSYVALPSENVAEIRVVLANRSATLYHMQKYQECLIDIKRALDLSYSKDLIYKLYERQARCYMALKDYPHTIDSFKKCITAMDDSTLASDKRAKLNLDAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPVACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGGYFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDACIDNWPKFDDLPRDVIRFRCDAPNNCSAVIEVPPSCNDFMVKCVTCGEITNILKGLKVMQDTEMMTRTAKRLYETGEYPKALAKFVDLIRIMYEVLAPPFPDFCESQQHLKDCFLNLGNVYTLD
Protein: Peptide synthetase MbtF (Peptide synthase) (O05819)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Protein MbtH
- Polyketide synthetase MbtC
- L-lysine N6-monooxygenase MbtG
- Polyketide synthetase MbtD
- Peptide synthetase MbtE
- Phenyloxazoline synthase MbtB
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Phthioceranic/hydroxyphthioceranic acid synthase
- Mycocerosic acid synthase-like polyketide synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
Sequence:
MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAAEADPYVIAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSAEVLWRHVRAHPSEVGALAAEERRRRFDVGRGPLIRFLLIELPDECWHLVIVAHHIVIDGWSLPLFVSELLALYRAGGHVAALPAAPRPYRDYIGWLAGRDQTASRAMWADHLNGLDGPTLLSPALADTPVQPGIPGRTEVRLDREATAELADAARTRGVTISTLVQMAWATTLSAFTGRGDVTFGVTVSGRPSELSGVETMIGLFINTVPLRVRLDARATVGGQCAVLQRQFAMLRDHSYLGFNEFRAIAGIGEMFDTLLVYENFPPGEVVGTAEFVANGVTFRPVALESLSHFPVTVAAHRSTGELTLLVEVLDGALGTMAPESLGRRVLAVLQRLVSRWDRPLRDVDILLDGEHDPTAPGLPDVTTSAPAVHTRFAEIAAAQPDSVAVSWADGQLTYRELDALADRLATGLRRADVSRETPVAVALSRGPRYVAAMLAVLKAGGMIVPLDPAMPGERVAEILRQTSAPVVIDEGVFAASVGADILEEDRAITVPVDQAAYVIFTSGTTGTPKGVIGTHRALSAYADDHIERVLRPAAQRLGRPLRIAHAWSFTFDAAWQPLVALLDGHAVHIVDDHRQRDAGALVEAIDRFGLDMIDTTPSMFAQLHNAGLLDRAPLAVLALGGEALGAATWRMIQQNCARTAMTAFNCYGPTETTVEAVVAAVAEHARPVIGRPTCTTRAYVMDSWLRPVPDGVAGELYLAGAQLTRGYLGRPAETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSDDQVKIRGFRVEPGEIAAVLNGHHAVHGCHVTARGHASGPRLTAYVAGGPQPPPVAELRAMLLERLPRYLVPHHIVVLDELPLTPHGKIDENALAAINVTEGPATPPQTPTELVLAEAFADVMETSNVDVTAGFLQMGLDSIVALSVVQAARRRGIALRARLMVECDTIRELAAAIDSDAAWQAPANDAGEPIPVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLAAVVDGHEVLRCRFDRDAMALVAQPKTDILSEVWVSGELVTAVAEQTLGALASLDPQAGRLLSAVWLREPDGPGVLVLTAHVLAMDPASWRIVLGELDAGLHALAAGRAPSPARENTSYRQWSRLLAQRAKALDSVDFWVAELEGADPPLGARRVAPQTDRVGELAITMSISDADLTARLLSTGRSMTDLLATAAARMVTAWRRQRGQQTPAPLLALETHGRADVHVDKTADTSDTVGLLSAIYPLRIHCDGATDFARIPGSGIDYGLLRYLRADTAERLRAHREPQLLLNYLGSLHVGVGDLAVDRALLADVGQLPEPEQPVRHELTVLAALLGPADAPVLATRWRTLPDILSADDVATLQSLWQGALAEITA
Protein: Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9) (P62080)
Organism: Mus musculus (Mouse)
Function: Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P62079}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 10
Sequence:
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
Protein: C2H2-like zinc finger protein (Q9FL64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNNQSMSSSSSSSPHKHDQKLKSALVAVEEKETINNPKQRSPQEIVSERTNLEMPSFRLSFFRKKRDTVLIHPPKDNKISHTCRFCKRNFKSCFALGGHMKCHKKERELEKQRKIIEDAMLCDSTPFTLQRLPVGPCKYGQGGSSHALSTDGINLDLTLGPSKSTGGSNNSTNNNTNSSFHGNLMTPVGPCVPRYSLVAGNQVDSSNIHVPAYPTTDLCYDFFALQEHGSGSSHSKSLISKGKNKVMVPEDDEDIGMIRWLPKKKRSRGE
Protein: VACUOLAR SORTING RECEPTOR 7 (F4JUS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
Sequence:
MGLVNGRASLTFLLAALTIIAMVVEARFVVEKESISVLNPEEMRSKHDGSIANFGLPDYGGFLIGSVVYPDSKTDGCSAFGKTFKPKFPRPTILLLDRGGCYFALKAWHAQQAGAAAVLVADNVDEPLLTMDSPEESKDADGFIEKLTIPSVLIDKSFGDDLRQGFQKGKNIVIKLDWRESVPHPDKRVEYELWTNSNDECGARCDEQMDFVKNFKGHAQILEKGGYTAFTPHYITWFCPFQFINSPHCKSQCINHGRYCAPDPEDNFREGYEGKDVVLENLRQLCVHRVANESSRPWVWWDYVTDFHSRCSMKEKKYSIDCAESYESLRLFSDLPIEKIKKCIGDPEADTENQVLRTEQVSQIGRGNRGDVTILPTLVINNAQYRGRLERTAVLKAICAGFNETSEPAICLNTGLETNECLENNGGCWQDTKANITACQDTFRGRLCECPVVKGVQYKGDGYTSCTPYGPARCTMNNGGCWSDTRNGLTFSACSDSVSTGCKCPEGFQGDGLTCEDINECKERSVCQCSGCRCKNSWGGYKCSCSGDRLYINDQDTCIERYGSKTAWWLTFLILAIVAVAGLAGYIFYKYRFRSYMDSEIMTIMSQYMPLESQRAREVPSEAEPFTL
Protein: Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) (GTP-dependent phosphoenolpyruvate carboxykinase) (GTP-PEPCK) (P9WIH3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the gluconeogenesis, in growth on fatty acids and is important for initiation of infection in the macrophages. Catalyzes the GTP-dependent conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00452}.
Interaction partners:
- Pyruvate carboxylase
- 2-oxoglutarate oxidoreductase subunit KorA
- Pyruvate kinase
- Malate dehydrogenase
- 2-methylcitrate synthase
- Probable pyruvate, phosphate dikinase PpdK
- Probable malate:quinone oxidoreductase
- Citrate synthase 1
- Putative citrate synthase 2
- Enolase
Sequence:
MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEFQRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMDPGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMGKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPILAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTAAAEGKVGNVRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG