wanglab/gogpt-training-data huggingface dataset:
Protein: NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Q9JIA3)
Organism: Rattus norvegicus (Rat)
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor p65
- NF-kappa-B inhibitor alpha
- Nuclear factor NF-kappa-B p105 subunit
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- NF-kappa-B essential modulator
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- REL proto-oncogene, NF-kB subunit
- NF-kappa-B inhibitor epsilon
- Transcription factor RelB
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a.
Sequence:
MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLVAELSPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVTERGGHTALHLACRVRAHTCAYVLLQPRPSHPRDASDTYLTQSQDHTPDTSHAPVATDPQPNPGNEEELRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVQLLRDAGADLNKPEPTCGRTPLHLAVEGQAAGVLALLLKAGADPTARMYGGRTPLGSALLRPNPVLARLLRAHGAPEPEDKDDKLSPCSNSSSDSDSDNRDEGDEYDDIVVHSRRSQNQPPPSPAAKPLPDDPNPA
Protein: RUN and SH3 domain containing 1 (A0A087WZ68)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL
Protein: Uncharacterized protein T09A5.5 (P45965)
Organism: Caenorhabditis elegans
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 8
Sequence:
MSVQNGFTAKIIRFVPHFVALRLSWTHNDLKAEGLEQFVEECLPAIRENNPQVKYFLQRSYTTCDPFVVGEYSWLRHRKKRVNWKSKEQVLSMIEEMSIGGDYREGYKRGVNRRLPRGQELWDTETMGHDVFHVTSKWKADIPEEDELPITAKTHPNFTYRKY
Protein: Syntaxin-binding protein 3 (MUNC-18-3) (Mammalian homolog of Unc-18c) (Munc-18c) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) (Q60770)
Organism: Mus musculus (Mouse)
Function: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:9045631}. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated (By similarity). {ECO:0000250}.
Interaction partners:
- Syntaxin-4
- Vesicle-associated membrane protein 2
- Synaptosomal-associated protein 23
- Syntaxin-3
- Syntaxin-1B
- Syntaxin-2
- Vesicle-associated membrane protein 8
- Syntaxin-1A
- Syntaxin-11
- Vesicle-associated membrane protein 3
Sequence:
MAPPVSERGLKSVVWRKIKTAVFDDCRKEGEWKIMLLDEFTTKLLSSCCKMTDLLEEGITVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKKYKAAYIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPQESQVYTLDVPDAFYYCYSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQISKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQRVKDSMLVLLPVLLNKNHDNCDKIRAVLLYIFGINGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGSGAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTHILTPRKLLDDIKMLNKSKDKVSFKDE
Protein: Pre-rRNA-processing protein IPI1 (Involved in processing IST2 protein 1) (P38803)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15528184}.
Interaction partners:
- Pre-rRNA-processing protein RIX1
- Pre-rRNA-processing protein IPI3
- Nucleolar GTP-binding protein 2
- Midasin
- Nucleolar GTP-binding protein 1
- Nuclear GTP-binding protein NUG1
- Ribosome assembly protein 4
- Probable metalloprotease ARX1
- Bud site selection protein 20
- Pescadillo homolog
Sequence:
MTKSRKQKQKKQDFLRKKLKVGKPKEKARNATDTSFVSKTISIRNQHLDQNPHDLTKRLTLLKHHNINVRKETLTTFQKSIPSIIKSRLMTPLLTQSIPLICDESQQVRQGLIDLVDEIGSHDAEILKLHCNIFVLYINMAMTHIVTQIQADSTKFLSHLLKYCGDEVVRKSWVKLLNGVFGVLGWGQVGKNDSASIVQTKKRNAKYVTIHLNALYTLVEYGCQDERARSDGDTAETTEDSGTLRNPYLIPDYPQPFEHLKLFTRELKVQDATSSGVNATLLSLATQDIDTRKAVFIEQFLPIVRKKIEVIIKEGGECGKSANKLKTLLAKIFD
Protein: Protein nemuri (Q8IP68)
Organism: Drosophila melanogaster (Fruit fly)
Function: Antimicrobial protein which is essential for the homeostatic regulation of sleep. Promotes sleep following sleep deprivation or bacterial infection and increases survival following bacterial infection. Likely to promote survival to bacterial infection in two ways; by contributing to the innate immune response and by promoting sleep during sickness to aid recovery.
Subcellular location: Secreted {ECO:0000269|PubMed:30705188}.
Interaction partners:
- RE25177p
- Sialin
Sequence:
MSAKYTLIFALAALCCLVFSTEAAAQRSRVLSSRRGSELVEKTSDNKEDSELAAQEQDLERQEQEEQNDRLEGRSDDVAEGSDNKEDKETATNNKDTIVKPNKDDARARRIVRAGRRRGGRRGGRRGGRRSARKSVRRGGRRGGRRRGGRRGRGGARRRTSVKRRSGKGNKA
Protein: Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) (Q9Z2P8)
Organism: Mus musculus (Mouse)
Function: May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Endomembrane system {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus.
Interaction partners:
- Vesicle-associated membrane protein 8
- Syntaxin-4
- Synaptobrevin homolog YKT6
- Syntaxin-19
Sequence:
MAGKELKQCQQQADEVTEIMLNNFDKVLERHGKLAELEQRSDQLLDMSSAFSKTTKTLAQQKRWENIRCRVYLGLAVAVGLLIILIVLLVVFLPSGGDSSKP
Protein: Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I] (P34928)
Organism: Mus musculus (Mouse)
Function: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02654}.
Interaction partners:
- Apolipoprotein E
- Apolipoprotein C-II
- Apolipoprotein C-III
- Apolipoprotein A-I
- Apolipoprotein B-100
- Apolipoprotein A-II
- Apolipoprotein C-IV
- Phosphatidylcholine-sterol acyltransferase
- Apolipoprotein A-V
- Beta-2-glycoprotein 1
Sequence:
MRLFIALPVLIVVVAMTLEGPAPAQAAPDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTRAWFSEAFGKVKEKLKTTFS
Protein: Synaptopodin-2 (Myopodin) (Q91YE8)
Organism: Mus musculus (Mouse)
Function: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11673475, ECO:0000269|PubMed:16309678, ECO:0000269|PubMed:17923693}. Cytoplasm {ECO:0000269|PubMed:11673475, ECO:0000269|PubMed:17923693}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11673475}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q9UMS6}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (PubMed:11673475, PubMed:15883195, PubMed:17923693). {ECO:0000250|UniProtKB:Q9UMS6, ECO:0000269|PubMed:11673475, ECO:0000269|PubMed:17923693}.
Interaction partners:
- Filamin-C
- BAG family molecular chaperone regulator 3
- Heat shock protein beta-8
- Myotilin
Sequence:
MGTGDFICISMTGGAPWGFRLQGGKEEQQPLQVAKIRSQSKASGSGLREGDEVVSINGNPCADLTYPEVIKLMEGITDSLHLLVKRPSSGTSETLDSESETTNHQHLTHEGPMESTTLQIQQATETQSEDFFLAPVQTKVPLTEDQSNAWGYAECPKEEQAPPMLGSQEGHLVEEVILRQKAEAGQPGHVVELQLSLSKERHQCTSGPIVTLQGNDKSTSPDPDWSSQLERTVHINSIPAPEKADTSLTSSTSSGRELRVIQGRDPGGAGLPQVEVILDCSDRLKAEECRLQTGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEHGEDQRSGKDQSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREEEEEEDQEAGDKDEISEVAFLGTSESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGGMAGGGPDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLASVPQQNGFSGVSETAGAQRMFPMNRTAKPFLGSMNQPAAPFSPTRSVTSPISDFPAPPPYSAVSPPPEAFSRGVSSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEAKRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGGDSGPEEDYLSLGAEACNFMQSSAKQKTPPPVAPKPAVKSPSSSQPVAPVSPVWSPGVAPAQRPAFSTSNPPNPPQVTAVSSIKIAQPAAPPARPASALNLAGPFKGPQAVVVSHNYTPKPSAPTPLVNAAPAGAGGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNASLFTFQPPDSKDGLPQKSTVKVSSAPAMKQALPPRQANVGSPTNAQASSVYSVPAYTSQPNFFAAEATSPVSASPVPVSVPTSPKQESTSTSYFVAPRPKFSAKKSGVTVQVWKPSVVEE
Protein: sulfiredoxin (EC 1.8.98.2) (F4I7W2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANLMMRLPISLRSFSVSASSSNGSPPVIGGSSGGVGPMIVELPLEKIRRPLMRTRSNDQNKVKELMDSIRQIGLQVPIDVIEVDGTYYGFSGCHRYEAHQKLGLPTIRCKIRKGTKETLRSSDWILRSICTLINLSSVPVAFCMNIILLLSVKLCGEGSLGQESIYPLYRTLMSHVPHMLDAIERSGLLIASMPKGG
Protein: General transcription factor IIIC subunit 5 (H7BY84)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWLRCCRLWAARKASPGEGYNNPPISGENLIGLSRARRPHNAIFVNFEDEEVPKQPLEAAAQTWRRVCTNPVDRKVEEELRKLFDIRPIWSRNAVKANISVHPDKLKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFRIRCGMKHGYAPSDLPVKAKRSTYNYSLPITVKKTSSQLVTMHDLKQGLGPSGTSGARKPASSKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIIHRNDGAENSCTERDGWCLPKTSDELRDTMSLMIRQTIRSKRPALFSSSAKADGGKEQLTYESGEDEEDEEEEEEEEEDFKPSDGSENEMETEILDYV
Protein: PSMC3 interacting protein (K7ERB6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP
Protein: Actin-binding LIM protein 1 (A0A8I6A592)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPEMTAVVDPRHISEGCKVAHPQDPHHSSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKEATCSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGSPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPPNIPRSSSDFFYPKSLIRRTGRSPALQPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQDRQSLGESPRTLSPTPSAEGFQDGRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHDAAALAAQNKASEDIIKFSKFPAAQAPDPNEIPKIETDHWPGPPSLAAIGTDPRRRSSGREEDEEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKENRERASLLASRYDSPLHSASHAPSSKTSSLPGYGKSGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILRDVDRTRLERHLAPEVFWEIFGMSIQEFDKLPLWRRNDMKKKAKLF
Protein: Cyclin-dependent kinase inhibitor rum1 (p25-rum1) (P40380)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulator of cell cycle G1 phase progression. Ensures the correct sequence of S phase and mitosis in the cell by acting as an inhibitor of the cdc2 mitotic kinase. Probably interacts with cdc2 to inhibit its action until the cell mass for Start is reached. Determines the length of the pre-Start G1 period and prevents mitosis from happening in early G1 cells. Required for maintaining pheromone-induced G1 arrest. Acts as an adapter protein since interaction with cdc13 promotes cyclin proteolysis during G1. Becomes a target for degradation at the G1/S phase transition, following phosphorylation by cig1-associated cdc2 at the G1/S phase transition.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- G2/mitotic-specific cyclin cdc13
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin cig2
- WD repeat-containing protein srw1
- G2/mitotic-specific cyclin cig1
- WD repeat-containing protein pop1
- Mitosis inhibitor protein kinase wee1
- Cell division control protein 18
- WD repeat-containing protein pop2
- Cyclin puc1
Sequence:
MEPSTPPMRGLCTPSTPESPGSFKGVIDASLEGNSSIMIDEIPESDLPAPQVSTFPPTPAKTPKKQLLPNLMLQDRSNSLERCMEEDREHNPFLSSSDNQLLSRKKRKPTPPPSDGLYYVFRGKRIKKSFRPGTDLSTFKPKLLFADSAPSSSSDNPTSSVDLNDYSQIGILPPNLNSIGNKMFSLKSRVPSSSSGSFVAPPPQMRLPAYSSPQKSRSNTKDENRHNLLR
Protein: Mitochondrial thiamine pyrophosphate carrier 1 (G8B6G7)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Fructose-1,6-bisphosphatase
- Malate synthase
- Citrate synthase
- Isocitrate lyase
Sequence:
MAASTEVKKQTKRGATDFVAGGVAGLFEALCCHPLDTIKVRMQLYRKSGQKPPGFIKTGINIVQKEGFLSLYKGLGAVVIGIVPKMAIRFSSYEFYRSFFYDKDGKITAGQTFLAGVGAGITESIMVVNPMEVVKIRLQAQHHSMKDPLDIPKYRNAPHAAYLIVKEEGFKTLYRGVSLTCARQATNQGVNFTVYSKLKEYLQKKQHTEMLPSWQTSGIGLISGALGPLSNAPLDTIKTRLQKSSYASNESGWVRIIKIGKQLIKEEGAAALYKGITPRIMRVAPGQAVTFTVYEFVKELLTKDSVSLTGNKEQKKLN
Protein: Uncharacterized protein (Q581T2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDGGISTGSHQHLGSIYRSLEYLPRYFQIFALFGAFFLASIRENPVIAWLAVTMHSSFGTEIVWSVEYQRRLELMTLNERLSLTLYGVALSALAMFTYVKTGRDVLYHLVQESGVDSNSRRWPVAIMCLMLACEGMVILKEEAACELSSSDSIAHFVLTGFRGFEQTGFDPRLKYANPHFLIQVQILKAYAMSFVKRMLPAVILAFVYRSGRDARRSAHAALRWYIMTIMIFRSLCEAYTMMYGDGLRQYSSWSLLLTSVVWYAMVNYTFGPSKRAGWTASTSSASSVRETTNGISKCIVLFFMVYLSVLALVVSVHVVELLLIWLMFFLLTVWIPAIIDSCAVSYIICITTAVSFVVYKMNHTTKWGSLRLIPLFSLWWLDICILYSLVANVTHSRFGGTLAVLVALGFHCYHSLEDLEHGVRTSGSYVEKVVTMLREVVEETVTMDEEVSAGPRTEKACYKTLVVVACAVMGFLISVAALLEYSQSSDVRVHLLNQNIILVTPRVLFRKFVRTFILVISLLVFVIAGLVMYRLVPQLAMFVPDFIALGVAVGVACAILGRLIDLQDPLYDALMRLIGAMEPPALTEDSVLDEGYGRWKHA
Protein: Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) (E9PLL6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPGYFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIIDVVRSVS
Protein: HoloCentric chromosome binding Protein (Q22257)
Organism: Caenorhabditis elegans
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim10
- Kinetochore-associated protein rod-1
- Mitochondrial import inner membrane translocase subunit Tim8
- BHLH domain-containing protein
- Protein CLASP-3
- Uncharacterized protein C30G12.6
- HMG box domain-containing protein
- SPK domain-containing protein
- G-protein regulator 2
- non-specific serine/threonine protein kinase
Sequence:
MEESTNDGDENKPATGKKRQQLESPFSAATPKSRLGKESKRFFGRSAMNLADGNLEETRIEPDSRHSSTSTSDSILDDSSISNFSTLAPPNTSVDDNSVCEPPRASSAHDVDPNLEQTKVYSEDSISKDCSIADESFATDGDVTLANDFFQQATIQDLENTPSTPLRSQTQVGDESTPTAPSPLRSKIPIESEVVQSTSVESVQSTSQHEKSRIEYSLYEFEMLEKNIEHDEVVKDLQLKIELLGEKHRQTLVEIKEAREVEEKMLMQQVEEAVKKTKSEREAAKTLEQLLEKRIEELEMKLTEPNGEKLQFEHQLEELKSRCEELTDKALKVDVMQHSIEDYEKKFVELQEMKEEADEQLQKAKEDIETLQMKYVELETTINKEVFSNSEIETLKSEHEIVRKLMLDEIHRLENEMSALQPKNDTTELEELQKTLDDLKIDCCNLTSKMLELQSELVEVKEKATSEIGEAVQKNGELLEQINSLRVENAKLVDMEGQLNDAHRKAEDKDVRISELLTTIESLRQDSEASDKLLMDSESTQNEYSLALENTVSELETMRREYKASVDKVCSLQLELEEIQHETSVELEEAEIRIKELELAQEEAVKTGSSQLKKLEIVQEDCQKLRDQLKEEQIQQLVSLRETSEVMHQESARHQEEKYQIQSKLMSTEAEVIELRSSIDSLQAEVRVQSDSAADQKHILEDYLRKIRQAEETNEKLRSDLASSEEQILDLKNQQESLIDDLKEKLHSAESTNQELQVSLEMLKIEVSNARQKVMESEVLKESFEALQLELSASQEVSRSVVDAAVQEKDGLLRLVDTLKLKIEDTEKSAQDLQQSSVEEIKQLQLDLQNFKQNAEVLESLNEKLNSSHKRDMVALASQLEELQHKLVVGESQVENVKEELIGAKIMNKEMVDELNAKLGDALEGMEELKKSLEVSEAKVQRREEELIAQVSKHRDQQEQLQLTLDELKSAQHSTETSRSQSNELAARIEELEASISFAQKALQDVEDVKHQQDIQISEANEAMVKLKQDFETERTSLQNEFNQTVSADKEQLGHAEQMIAQKEKEIITLQARIEAMSQQFEERLEASNVWKTQAMNVGTLTESLSQLQVQLQQMNEKLVASDKYAVEVEQQAQHDITVIQEEKNEQSAALEEALSKIAELEEQLGRAQKEIVRLEKVCDDFDDVERELKDAISKLQSEIKQLKGIKKPPKVMGLLQQARLGVKPLSREHSHAEPPEPVVEDKFEDAQDSFQEEFSHSPDAITSSTVLHPDDHLQETTAVETPSKKANRSNCNQQ
Protein: Duffy binding-like merozoite surface protein (Q8IJ52)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKKIYSIFFSLFILNLHIYIKNIKCNDLINYNDSNLRNGLLNNSLDLTNGLNNKDNSFIDSKIEEHENKSYQNKDNNISIVGQDVPITSVYSSKIINANDLEGNSIDDTKGLSVTNSGFDDGSAFGGGLPFSGYSPLQGNHNKCPDENFCKGIKNVLSCPPKNSTGRNGDWISVAVKESSTTNKGVLVPPRRTKLCLRNINKVWHRIKDEKNFKEEFVKVALGESNALMKHYKEKNLNALTAIKYGFSDMGDIIKGTDLIDYQITKNINRALDKILRNETSNDKIKKRVDWWEANKSAFWDAFMCGYKVHIGNKPCPEHDNMDRIPQYLRWFREWGTYVCSEYKNKFEDVIKLCNIQQFTNQDDSQLLEISKKDKCKEALKHYEEWVNRRRPEWKGQCDKFEKEKSKYEDTKSITAEKYLKEICSECDCKYKDLDNTFKEFKDNVTLLKAVIDNKKNQDSLTTTSLSTSINSVRDSSNLDQRGNITTSQGNSHRATVVQQVDQTNRLDNVNSVTQRGNNNYNNNLERGLGSGALPGTNIITEEKYSLELIKLTSKDEEDIIKHNEDVREEIEEQQEDIEEDEEELENEGEETKEEDDEEKNETNDTEDTDDTEDTEDIEEENKEKELSNQQQSEKKSISKVDEDSYRILSVSYKDNNEVKNVAESIVKKLFSLFNDNNNLETIFKGLTEDMTDLFQK
Protein: Palustrin-2c (P84280)
Organism: Lithobates palustris (Pickerel frog) (Rana palustris)
Function: Antimicrobial activity against Gram-negative bacterium E.coli.
Subcellular location: Secreted {ECO:0000269|PubMed:11087945}.
Interaction partners:
Sequence:
GFLSTVKNLATNVAGTVIDTLKCKVTGGCRS
Protein: Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1) (Q5MJ70)
Organism: Homo sapiens (Human)
Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2.
Subcellular location: Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1B
- SUN domain-containing protein 1
- Cyclin-dependent kinase 1
- M-phase inducer phosphatase 3
- Nuclear transcription factor Y subunit beta
- Nuclear transcription factor Y subunit alpha
- DNA polymerase epsilon subunit 3
- Telomere repeats-binding bouquet formation protein 2
- Telomere repeats-binding bouquet formation protein 1
Sequence:
MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE
Protein: CARD-like protein (Si:ch211-195h23.3) (Uncharacterized protein LOC100170660) (B0V1H3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- Si:dkey-238k10.3.
- NACHT, LRR and PYD domains-containing protein 3-like
- NLR family CARD domain-containing protein 3
- Si:ch211-196h16.4.
- Si:ch211-196h16.5.
Sequence:
MESSQSDECMSDSEDEGECTSDSDDERGMRISLSDSDDESTSKRRFRHPRSLSMGTRSRTVKRHRFHRLQASKKTETVLEHVDGAESSSGQTPSDDAEIFTPELIQEDDKYKDKNTYRFVCPHAGQFQCSLTSLVFVMDGEGELLYRVVSWDPRLLDGLGQMQPAGPLYDVKCFNGSISKLHLPHCEIFSEGDNMDGLAVAHFTGGNMEIVQPITVTETHVMIDIRDLSLFGLLWMKIFSHPISGQVLLFLRTLPVEEEEEEEKILNVHLLPGNVPVSEVVHSHQDKKYIETTSKCHLFLEREYSLRCQPENCEVQPKSEIFEHNNFGPNFHPSFQVFLSVDVKKVGLTILDKAEDCKEVWSRPRVSLKAPSQGVEPPEHRMISGSEFVDALRGKLIQRVSSVMAIADSLRSKHMITDELYSELHNADTNQRKMRCLFMALDSGGASVKAEFYRLLKKNEPHLVEELESGHSKSFRRQ
Protein: SR-CI (Q5ELU4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSIDLDNGSINYRQRNVVRFRCNRGYTLQGTVMQTCDRDGRLRGEKPFCASRGCARPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFTTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSVPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTTMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLKKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (Q7KJ08)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- GH16255p
- Neurofibromin 1, isoform B
- E3 ubiquitin-protein ligase CBL
- DShc protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
Sequence:
MPQLRQLVVVLAILSLLVDPSFAQRPLIMNHTFSSLPMSQHPSFNSWPSASGGKQLRNGRLHEQPLPLPQPTLPVATQYEDYEAAPPGSRRDNKRRLAQMAQRPGSGNGGRRGMESLRKELMNPSVGGPGGGISGGGSGYPSYSATSSIGRIDGLGQGLGSADRYGALYDQLRQPSGMAAMTAGPLGGPYSTRFPPLYAGVDDQPKRSNRKNSISELYKLKKALNQADEPAGGVTHGNFEGDPQPSSADPLQEIKDRIRDTSPNANTYAPHTDATPSSEYEYELGVKCNFETPCSWTWGNYSDGFQVITGTELSKRNLTGLLPGPAADSIDDANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWVPAEILGDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSGYVPELQRQQMSSCTPPAVTSPAAPHPRPVENIAPTSGDCWETSFILPNSKVEPPVVGSGHDVPLAGGEEAKLISLDTPQPTPTTIQPPLSFASQLDGITLDPSALTKSLPNGNAKQSYANVQVKNEAEAKVINGVVGNGTVMNGDVSTGSGGADSPFTIQGYAERYKDNNNHSEISC