wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar fusion protein CCZ1 homolog (P86791)
Organism: Homo sapiens (Human)
Function: Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:17897319}.
Interaction partners:
Sequence:
MAAAAAGAGSGPWAAQEKQFPPALLSFFIYNPRFGPREGQEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKPVIEYQEEELLDKVYSSVLRQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLNIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPDAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASVHPTLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTVHMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDRRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD
Protein: Male-specific sperm protein Mst84Da (Q01642)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Male-specific sperm protein Mst84Dc
- Male-specific sperm protein Mst84Dd
- GH09231p
- Tubulin beta-2 chain
- GH14622p
- Sex-regulated protein janus-B
- GEO13348p1
- Uncharacterized protein, isoform C
- AT18965p
- 10 kDa heat shock protein, mitochondrial
Sequence:
MYMYVNPNYVLVGGPCCGPCGGCGPCGGCGPCCGGCGPCCGPCGGCGPCCGGTSSFCGCGPCC
Protein: Rap guanine nucleotide exchange factor-like 1 (Link guanine nucleotide exchange factor II) (Link GEFII) (Q9UHV5)
Organism: Homo sapiens (Human)
Function: Probable guanine nucleotide exchange factor (GEF).
Interaction partners:
Sequence:
MKPLEKFLKKQTSQLAGRTVAGGPGGGLGSCGGPGGGGGPGGGGGPAGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPVPEEGGEPAGVAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLNRVLERLAGGATRDSAASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
Protein: Succinate-CoA ligase GDP-forming subunit beta (H0Y852)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK
Protein: SUR1 (A0A1S4NYG1)
Organism: Mesocricetus auratus (Golden hamster)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVKKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLAPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNLPDSEGEDPSSPERETAAGSDIRSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKASEPSQGLPRAMSSRDGLLLDEEEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECDLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVRADK
Protein: Cytochrome bd-I ubiquinol oxidase subunit 1 (EC 7.1.1.7) (Cytochrome bd-I oxidase subunit I) (Cytochrome d ubiquinol oxidase subunit I) (P0ABJ9)
Organism: Escherichia coli (strain K12)
Function: A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:16079137}.
Interaction partners:
- Cytochrome bd-I ubiquinol oxidase subunit 2
- Cytochrome bd-I ubiquinol oxidase subunit X
- Cytochrome bd-II ubiquinol oxidase subunit 2
- Uncharacterized protein YnhF
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydD
- Cytochrome bd-II ubiquinol oxidase subunit 1
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydC
- Cytochrome bo
- Uncharacterized protein YbgE
- Cytochrome bo
Sequence:
MLDIVELSRLQFALTAMYHFLFVPLTLGMAFLLAIMETVYVLSGKQIYKDMTKFWGKLFGINFALGVATGLTMEFQFGTNWSYYSHYVGDIFGAPLAIEGLMAFFLESTFVGLFFFGWDRLGKVQHMCVTWLVALGSNLSALWILVANGWMQNPIASDFNFETMRMEMVSFSELVLNPVAQVKFVHTVASGYVTGAMFILGISAWYMLKGRDFAFAKRSFAIAASFGMAAVLSVIVLGDESGYEMGDVQKTKLAAIEAEWETQPAPAAFTLFGIPDQEEETNKFAIQIPYALGIIATRSVDTPVIGLKELMVQHEERIRNGMKAYSLLEQLRSGSTDQAVRDQFNSMKKDLGYGLLLKRYTPNVADATEAQIQQATKDSIPRVAPLYFAFRIMVACGFLLLAIIALSFWSVIRNRIGEKKWLLRAALYGIPLPWIAVEAGWFVAEYGRQPWAIGEVLPTAVANSSLTAGDLIFSMVLICGLYTLFLVAELFLMFKFARLGPSSLKTGRYHFEQSSTTTQPAR
Protein: ARL14 effector protein (ARF7 effector protein) (Q8N8R7)
Organism: Homo sapiens (Human)
Function: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21458045}.
Interaction partners:
- Histone-lysine N-methyltransferase SETDB2
- Activating transcription factor 7-interacting protein 1
- Activating transcription factor 7-interacting protein 2
- Histone-lysine N-methyltransferase SETDB1
- ADP-ribosylation factor-like protein 14
Sequence:
MMDPCSVGVQLRTTNECHKTYYTRHTGFKTLQELSSNDMLLLQLRTGMTLSGNNTICFHHVKIYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDTEDRQKRKPESDGRTAKALRSLQFTNPGRQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPACGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAG
Protein: Nucleoside permease (Q9KPL5)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSLFMSLIGMAVLLGIAVLLSSNRKAINLRTVGGAFAIQFSLGAFILYVPWGQELLRGFSDAVSNVINYGNDGTSFLFGGLVSGKMFEVFGGGGFIFAFRVLPTLIFFSALISVLYYLGVMQWVIRILGGGLQKALGTSRAESMSAAANIFVGQTEAPLVVRPFVPKMTQSELFAVMCGGLASIAGGVLAGYASMGVKIEYLVAASFMAAPGGLLFAKLMMPETEKPQDNEDITLDGGDDKPANVIDAAAGGASAGLQLALNVGAMLIAFIGLIALINGMLGGIGGWFGMPELKLEMLLGWLFAPLAFLIGVPWNEATVAGEFIGLKTVANEFVAYSQFAPYLTEAAPVVLSEKTKAIISFALCGFANLSSIAILLGGLGSLAPKRRGDIARMGVKAVIAGTLSNLMAATIAGFFLSF
Protein: Zinc finger CCCH domain-containing protein C337.12 (O74823)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized RNA-binding protein C902.04
- Uncharacterized protein C7D4.14c
- NURS complex subunit red1
- Uncharacterized helicase C17H9.02
- NURS complex subunit pir2
- Polyadenylate-binding protein 2
- RNA binding exosome specificity factor Mmi1
- Poly
- Nuclear cap-binding protein subunit 2
- Nuclear cap-binding protein subunit 1
Sequence:
MNEQQLLENIASLAGAINQYKNEKEPTQVLDAAKANKNTRSYPYSVSRNYSFILNKSNRSKSTAASPPYVIPSTSSNADDANKEPEKQSTSDYVSRKNRHMQLIKKNILEHDLQARKANLESYRAKLEKEYKTLAENKIQQRLSDGTKQLVTIDGLQYITGVSDTKWLEFVSAKGQCPKYLYWNNKSYLLKKKRFLKEVGNSPSAVYCRYYNANGICGKGAACRFVHEPTRKTICPKFLNGRCNKAEDCNLSHELDPRRIPACRYFLLGKCNNPNCRYVHIHYSENAPICFEFAKYGFCELGTSCKNQHILQCTDYAMFGSCNNPQCSLYHGAVSADVPEQTEAPISKTAGSINPEDSGSEIGSNSLESNLDFISV
Protein: Succinate dehydrogenase subunit 3-2, mitochondrial (Q84VK7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase subunit 3-1
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase subunit 5
- Succinate dehydrogenase subunit 8B
- Succinate dehydrogenase subunit 8A
- Succinate dehydrogenase subunit 6
- Succinate dehydrogenase subunit 4
- Succinate dehydrogenase subunit 7
Sequence:
MEKYQSKARFAPLSDAPFALRGALGSSNSSFNNIDHLRQSSSSGQARSYTSSPLGALRPKMFPSGNRLLHTSRPLSAPVANRPLSPHLPLKKPQLSATFSISHRIFGAALGAVIISIPLATKFSLMFDV
Protein: DNA glycosylase/AP lyase ROS1 (EC 4.2.99.18) (DEMETER-like protein 1) (Protein REPRESSOR OF SILENCING 1) (Protein ROS1) (Q9SJQ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity. Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate. Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:12526807, ECO:0000269|PubMed:25569774}. Nucleus, nucleolus {ECO:0000269|PubMed:25569774}. Note=Co-localizes in nucleoplasmic foci with APE1L and ZDP, two components of the DNA demethylase machinery. {ECO:0000269|PubMed:25569774}.
Interaction partners:
- Protein REPRESSOR OF SILENCING 3
- DNA-directed RNA polymerase V subunit 1
- DNA
- Increased DNA methylation 1
- DNA-directed RNA polymerase IV subunit 1
- DNA
- DNA
- DNA
- ATP-dependent DNA helicase DDM1
- Histone H3-like 2
Sequence:
MEKQRREESSFQQPPWIPQTPMKPFSPICPYTVEDQYHSSQLEERRFVGNKDMSGLDHLSFGDLLALANTASLIFSGQTPIPTRNTEVMQKGTEEVESLSSVSNNVAEQILKTPEKPKRKKHRPKVRREAKPKREPKPRAPRKSVVTDGQESKTPKRKYVRKKVEVSKDQDATPVESSAAVETSTRPKRLCRRVLDFEAENGENQTNGDIREAGEMESALQEKQLDSGNQELKDCLLSAPSTPKRKRSQGKRKGVQPKKNGSNLEEVDISMAQAAKRRQGPTCCDMNLSGIQYDEQCDYQKMHWLYSPNLQQGGMRYDAICSKVFSGQQHNYVSAFHATCYSSTSQLSANRVLTVEERREGIFQGRQESELNVLSDKIDTPIKKKTTGHARFRNLSSMNKLVEVPEHLTSGYCSKPQQNNKILVDTRVTVSKKKPTKSEKSQTKQKNLLPNLCRFPPSFTGLSPDELWKRRNSIETISELLRLLDINREHSETALVPYTMNSQIVLFGGGAGAIVPVTPVKKPRPRPKVDLDDETDRVWKLLLENINSEGVDGSDEQKAKWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNVSDHLSSSAFMSLASQFPVPFVPSSNFDAGTSSMPSIQITYLDSEETMSSPPDHNHSSVTLKNTQPDEEKDYVPSNETSRSSSEIAISAHESVDKTTDSKEYVDSDRKGSSVEVDKTDEKCRVLNLFPSEDSALTCQHSMVSDAPQNTERAGSSSEIDLEGEYRTSFMKLLQGVQVSLEDSNQVSPNMSPGDCSSEIKGFQSMKEPTKSSVDSSEPGCCSQQDGDVLSCQKPTLKEKGKKVLKEEKKAFDWDCLRREAQARAGIREKTRSTMDTVDWKAIRAADVKEVAETIKSRGMNHKLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSVECVRLLTLHHLAFPVDTNVGRIAVRLGWVPLQPLPESLQLHLLEMYPMLESIQKYLWPRLCKLDQKTLYELHYQMITFGKVFCTKSKPNCNACPMKGECRHFASAFASARLALPSTEKGMGTPDKNPLPLHLPEPFQREQGSEVVQHSEPAKKVTCCEPIIEEPASPEPETAEVSIADIEEAFFEDPEEIPTIRLNMDAFTSNLKKIMEHNKELQDGNMSSALVALTAETASLPMPKLKNISQLRTEHRVYELPDEHPLLAQLEKREPDDPCSYLLAIWTPGETADSIQPSVSTCIFQANGMLCDEETCFSCNSIKETRSQIVRGTILIPCRTAMRGSFPLNGTYFQVNEVFADHASSLNPINVPRELIWELPRRTVYFGTSVPTIFKGLSTEKIQACFWKGYVCVRGFDRKTRGPKPLIARLHFPASKLKGQQANLA
Protein: Meiotically up-regulated gene 5 protein (O13715)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for correct meiotic chromosome segregation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 1 protein
- Meiotically up-regulated gene 4 protein
- Meiotic coiled-coil protein 3
- Microtubule-associated protein ssm4
- Centractin
- Actin-like protein arp10
- Meiotically up-regulated gene 8 protein
- Reduced meiotic recombination protein C1442.04c
Sequence:
MCYLSRMSSQQMQLTISGFENRIKILEDLMNEFDSNLYIRLKRECDFKLPKEYDVSIHALTILMKRHLSNMEPIDCYQDLDTGTLQTMLIFCCTLRMIEHYEKSLSNINFFSLSNDLKRLEEYNTSCSVLLSLYQRQLKKISTTIESYYLADTLRHNQNILNLCERIYNIQKLLNKREKASVLRH
Protein: Short coiled-coil protein (A0A0C4DGB0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255}. Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
Interaction partners:
Sequence:
MMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK
Protein: Neural precursor cell expressed, developmentally down-regulated 9 (A0A087WUD2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MKYKVITPVRTGHGYVYEYPSRYQKDVYDIPPSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKDYDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
Protein: Caveolin-1 (P49817)
Organism: Mus musculus (Mouse)
Function: May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269|PubMed:19546242, ECO:0000269|PubMed:21610094}; Peripheral membrane protein {ECO:0000269|PubMed:21610094}. Membrane raft {ECO:0000250|UniProtKB:Q03135}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724}. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
Interaction partners:
- Caveolin-2
- Caveolae-associated protein 1
- Epidermal growth factor receptor
- Proto-oncogene tyrosine-protein kinase Src
- Estrogen receptor
- Caveolin-3
- Integrin beta-1
- Tyrosine-protein kinase Fyn
- Major prion protein
- Dipeptidyl peptidase 4
Sequence:
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADEVTEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSTIFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKIFSNIRISTQKEI
Protein: Biliverdin reductase A (BVR A) (EC 1.3.1.24) (A0A140VJF4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|PIRNR:PIRNR037032}.
Interaction partners:
Sequence:
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLEDALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLENVPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
Protein: Probable LRR receptor-like serine/threonine-protein kinase At4g29180 (EC 2.7.11.1) (C0LGR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Putative pectinesterase/pectinesterase inhibitor 24
- Putative methylesterase 15, chloroplastic
- Uncharacterized protein
- Probable pectate lyase 16
- Protein DETOXIFICATION 31
- Protein kinase superfamily protein
- Peroxidase 35
- Xyloglucan endotransglucosylase/hydrolase protein 14
- Extensin-like protein
- Proline-rich protein 1
Sequence:
MGAHSVFLILFSVIAIAIVVHGQGQAGFISIDCGSPPNINYVDTDTGISYTWDAPFINAGVNLNVSEEYGYPKNPVLPFPLADVRSFPQGNRNCYTLTPSDGKGNLYLIRASFMYGNYDGKNALPEFDLYVNVNFWTSVKLRNASENVIKEILSFAESDTIYVCLVNKGKGTPFISALELRPMNSSIYGTEFGRNVSLVLYQRWDTGYLNGTGRYQKDTYDRIWSPYSPVSWNTTMTTGYIDIFQSGYRPPDEVIKTAASPKSDDEPLELSWTSSDPDTRFYAYLYFAELENLKRNESREIKIFWNGSPVSGAFNPSPEYSMTVSNSRAFTGKDHWISVQKTAESTRPPILNAIEIFSAQSLDEFYTRIDDVQAIESIKSTYKVNKIWTGDPCSPRLFPWEGIGCSYNTSSYQIKSLNLSSSGLHGPIAFAFRNLSLLESLDLSNNNLKGIVPEFLADLKYLKSLNLKGNNLTGFIPRSLRKRATANGLALSVDEQNICHSRSCRDGNRIMVPIVVSTLVIILIAALAIICIMRRESKIMYSGAYSGPLLPSGKRRFTYSEVSSITNNFNKVIGKGGFGIVYLGSLEDGTEIAVKMINDSSFGKSKGSSSSSSSSQVSKEFQVEAELLLTVHHRNLASFVGYCDDGRSMALIYEYMANGNLQDYLSSENAEDLSWEKRLHIAIDSAQGLEYLHHGCRPPIVHRDVKTANILLNDNLEAKIADFGLSKVFPEDDLSHVVTAVMGTPGYVDPEYYNTFKLNEKSDVYSFGIVLLELITGKRSIMKTDDGEKMNVVHYVEPFLKMGDIDGVVDPRLHGDFSSNSAWKFVEVAMSCVRDRGTNRPNTNQIVSDLKQCLAAELAREPKSNHEKKEVVKEKYTKTKSTVQNYSSNEYNSSSGSVSLSFGDYSTFGPMAR
Protein: Ras-like protein family member 11B (EC 3.6.5.2) (Q6P0U3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Doublecortin domain-containing 2B.
- CDC42 effector protein
Sequence:
MRLIQNMSTIAEYPSADCPSSRVIKIAVIGGSGVGKTALVVRFLTKRFIGDYERNVGNLYSREVQIDGEQVAIQVQDTPGVQVNANGLSCTDHVSRSIQWADAVVMVYSVTDRKSFDLIGQLHQLVTRTHSDRSIPIILVANKADLLHVRRVDAQEGPVLSSALSCSFYEVSASEDYNQVHSAFHRLCVDLAKLQPQTPINATSSVTEKKRSPLIPRPKSPNMQDLKRRFKQVLSAKVRTVTSV
Protein: Cathepsin K (EC 3.4.22.38) (O35186)
Organism: Rattus norvegicus (Rat)
Function: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P43235}. Secreted {ECO:0000250|UniProtKB:P43235}. Apical cell membrane {ECO:0000250|UniProtKB:P43235}; Peripheral membrane protein {ECO:0000250|UniProtKB:P43235}; Extracellular side {ECO:0000250|UniProtKB:P43235}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000250|UniProtKB:P43235}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 11
- Nuclear factor of activated T-cells 1
- Collagenase 3
- Apoptosis regulator Bcl-2
- BH3-interacting domain death agonist
- Bcl-2-like protein 1
- Serpin B13
- Dendrocyte expressed seven transmembrane protein
- Matrix metalloproteinase-9
- Matrilysin
Sequence:
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
Protein: Krueppel-like factor 6 (Core promoter element-binding protein) (O08584)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor Jun
- Cellular tumor antigen p53
- Cyclic AMP-dependent transcription factor ATF-3
- Dual specificity protein phosphatase 1
- G1/S-specific cyclin-D1
- Protein BTG2
Sequence:
MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKFILAREKKEESELKISSSPPEDSLISSSFNYNLETNSLNSDVSSESSDSSEELSPTTKFTSDPIGEVLVNSGNLSSSVISTPPSSPEVNRESSQLWGCGPGDLPSPGKVRSGTSGKSGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL
Protein: Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Q0VGM9)
Organism: Mus musculus (Mouse)
Function: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:15210109, ECO:0000269|PubMed:24115439}. Note=Colocalizes with PCNA within the replication foci in S-phase cells.
Interaction partners:
- Telomeric repeat-binding factor 1
- TERF1-interacting nuclear factor 2
- Telomerase Cajal body protein 1
- Telomerase reverse transcriptase
- H/ACA ribonucleoprotein complex subunit DKC1
- ATP-dependent DNA helicase PIF1
- CST complex subunit CTC1
- H/ACA ribonucleoprotein complex subunit 2
- MMS19 nucleotide excision repair protein homolog
- H/ACA ribonucleoprotein complex subunit 3
Sequence:
MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQLTQVIRELRNTAYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYLKVYDNFGHVIRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAMSLDVHVPSLRQKPIGLPAAGDSESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGSSTPSLRCEKRLSTEQKGGRKKVRLVNHPEEPMAGTQAGRAKMFMVAVKQALSQANFDTFTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLTGQRCGYQPGKRELESKLTLSEGVDRQLDPGQHLNQGQPHLSAHPTSKGHTSHCTKVGCAVEKPGQPAVSDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVVAVVAALTTAKPEHLPLLQRFGMFVRRHHKPQFLQTCADLMGLPTTGKDLELEGPRDESPTVPPELTHEDLKPGPSMSKKPEKTQSKISSFFRQRPDESVRSDDTTPKPMQLPPRLPHELMKPHRSKQ