wanglab/gogpt-training-data huggingface dataset:
Protein: DNA endonuclease SAE2 (EC 3.1.-.-) (Completion of meiotic recombination protein 1) (Sporulation in the absence of SPO11 protein 2) (P46946)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Endonuclease that cooperates with the MRX complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of SPO11 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for proper recovery from checkpoint-mediated cell cycle arrest after DNA damage. MRX complex and SAE2 remove a small oligonucleotide(s) from the DNA ends to form an early intermediate which is rapidly processed by EXO1 and/or SGS1 to generate extensive tracts of single-stranded DNA that serve as substrate for RAD51. Plays a transitional role in the dissociation of MRE11 from, and the recruitment of RAD52 to, repair foci. Ensures that both ends of a DSB participate in a recombination event and impairs the formation of palindromic structures in the genome. With TEL1, promotes microhomology-mediated end joining (MMEJ) but inhibits non-homologous end joining (NHEJ), likely by regulating MRE11-dependent ssDNA accumulation at DNA break. SAE2 and MRX are particularly important for removal of hairpins, bulky adducts and other irregular end structures. Facilitates telomere length reequilibration and subsequent checkpoint switch off. Involved in homing efficiency of VMA1 intein VDE and in repair of transposon excision sites.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:15369670, ECO:0000269|PubMed:18670132}. Note=Accumulates in foci at the precise time when MRE11 foci disassemble and RAD52 foci assemble (PubMed:18670132). Remains associated with DSBs along with MRE11 in nuclease-deficient cells (PubMed:18670132).
Interaction partners:
- ATP-dependent helicase SGS1
- Exodeoxyribonuclease 1
- Double-strand break repair protein MRE11
- DNA repair protein RAD50
- DNA replication ATP-dependent helicase/nuclease DNA2
- Serine/threonine-protein kinase TEL1
- Serine/threonine-protein kinase MEC1
- Meiosis-specific protein SPO11
- DNA repair protein XRS2
- DNA repair protein RAD9
Sequence:
MVTGEENVYLKSSLSILKELSLDELLNVQYDVTTLIAKRVQALQNRNKCVLEEPNSKLAEILCHEKNAPQQSSQTSAGPGEQDSEDFILTQFDEDIKKESAEVHYRNENKHTVQLPLVTMPPNRHKRKISEFSSPLNGLNNLSDLEDCSDTVIHEKDNDKENKTRKLLGIELENPESTSPNLYKNVKDNFLFDFNTNPLTKRAWILEDFRPNEDIAPVKRGRRKLERFYAQVGKPEDSKHRSLSVVIESQNSDYEFAFDNLRNRSKSPPGFGRLDFPSTQEGNEDKKKSQEIIRRKTKYRFLMASNNKIPPYEREYVFKREQLNQIVDDGCFFWSDKLLQIYARC
Protein: Uncharacterized protein, isoform A (Q9W2J5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKLLTSADIEDGKVEFDKATGATTTYKVIEGGYEVITTSPQPNGTIKTQVRTFWDPKPVSEEDLKKEQENKKLVQKRLGKEIRIDERTTMLTRAIEGGYEEVYTTINEDGTRSSRTKTFYDSVPTEVDEKTAAKLNKNKKNVTRKSSVDSTDSTESSRRIVQKQQKNLVQNYDEQTNSTTTSERRVSVTQNIEITENNRTVRKNSLQEQNVKAITTTSNTSSSDKKQKKKPKSSAPPPPADFFQNDTTSVASKRVPGGVEYTYSTQLDSGKTITTSKTVYEEEEVELTEEEIRQYKKTLKDAEKHKNVSTTKKLKSESGTKKIVPSENPGDVTTVETIKIEGGTEYHYTTVTSEGIVKKAVKTVYDPVPSQKSNPDDTDEEEIIEEYEEEIIEPGEKNVKTIETVKQLPSKFEEEVTITHERKEKKVKKSMVISQ
Protein: Zinc finger protein 726 (A6NNF4)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MGLLTFRDVAIEFSLEEWQCLDTAQKNLYRNVMLENYRNLAFLGIAVSKPDLIICLEKEKEPWNMKRDEMVDEPPGICPHFAQDIWPEQGVEDSFQKVILRRFEKCGHENLQLRKGCKSVDECKVHKEGYNGLNQCFTTTQGKASQCGKYLKVFYKFINLNRYKIRHTRKKPFKCKNCVKSFCMFSHKTQHKSIYTTEKSYKCKECGKTFNWSSTLTNHKKTHTEEKPYKCEEYGKAFNQSSNYTTHKVTHTGEKPYKCEECGKAFSQSSTLTIHKRIHTGEKPCKCEECGKAFSQPSALTIHKRMHIGEKPYKCEECGKAFVWSSTLTRHKRLHSGEKPYKCEECAKAFSQFGHLTTHRIIHTGEKPYKCEECGKAFIWPSTLTKHKRIHTGEKPYKCEECGKAFHRSSNLTKHKIIHTGEKPYKCEECGKAFIWSSNLTEHKKIHTREKPYKCEECSKAFSRSSALTTHKRMHTGEKPYKCEECGKAFSQSSTLTAHKIIHTGEKPYKCEECGKAFILSSTLSKHKRIHTGEKPYKCEECGKTFNQSSNLSTHKIIHTGEKPYKCEECGKAFNRSSNLSTHKIIHTGEKPYKCDECGKSFIWSSTLFKHKRIHT
Protein: SPerm CHromatin enriched (P91026)
Organism: Caenorhabditis elegans
Interaction partners:
- Major sperm protein
- SPerm CHromatin enriched
- PDZ domain-containing protein
- PDZ domain-containing protein
- Sperm-Specific family, class Q
- Sperm-specific class P protein 16
- MS Related Protein
- SPerm CHromatin enriched
- BAR domain-containing protein
- MS Related Protein
Sequence:
MPKSKSQKNKLRPRDSKGRFTPLAKAKRTVVSRSRSRSRSASRGARQSRSVGRPMSRRNSVRSISTHTAKSPSLVLVISGSPSPRRRRPSTRRSSSRRSVVRSVSRGSKSRRSSSRGSVYGRTGRSRSSKRSRSRSRPRTRSGSRSSSRSRSGSRRSSRRRSRRRSSSKARGRRASTAKKTPAKRRSRSRSQQKVKRSMSRKG
Protein: Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor) (P53801)
Organism: Homo sapiens (Human)
Function: May facilitate PTTG1 nuclear translocation.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10781616}. Nucleus {ECO:0000269|PubMed:10781616}. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.
Interaction partners:
- Securin
Sequence:
MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN
Protein: Protein Wnt-3a (P56704)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P27467}. Secreted {ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 6
- Low-density lipoprotein receptor-related protein 5
- Frizzled-1
- Frizzled-2
- Protein wntless homolog
- Frizzled-8
- Wnt inhibitory factor 1
- Glypican-3
- Protein-serine O-palmitoleoyltransferase porcupine
- Catenin beta-1
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
Protein: Eukaryotic translation initiation factor 4 gamma 1 (C9JF13)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQM
Protein: Cilia- and flagella-associated protein 74 (Flagella-associated protein 74) (D4P3R7)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: As part of the central apparatus of the cilium axoneme may play a role in cilium movement and thereby cell motility.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:20421426}.
Interaction partners:
Sequence:
MALTAEEAYLEELWREEDEQSEEATAMQQMLAHQHEQQHDALPSYQELMGQGSPAVTLRRAKAAAAANGTSSPGIRGSPSPARGPGGRLPSLAMGPTVGANVEQLKRRLQTVVAEVEGHQQRYDKVLLEANKATDLVHSMEAEIESLYVEAEELARRVPPAAERQRQVATWLAQRSAALEAQRQVLGGKQLELIEAEAALRAAETELDFMAEARNEIAAAQAAETAALSAAAATLRGKEDKAVAGYRRKQAAEAARLADVAAAAEDLAQRRIQAAEEAQAQAMERLKANTERIREGIASGRDLLAAEQSRRREAVLGLKESLAAVQADVAQQAELARVLQRQRRDLQEKEFGALVEAGMNPYEVFRRRDQEAAAARQHEAITSNIATRQLEVAAQLAREQEAYAQKLAARKREKKTREIFDREMGPAAQQARTEAYMQAHTVGGVSMLDPTGRVQPFPSEAVVVKTRRFGRGGAPEEVLQQQLQRLGDDTQPKQLLLPAKYRNTADTDAAAVAGLGRGGGSDDEDGMGSPPRSPSLTQQLAATQQSLTATASLAQQQQQAAGDRYKQLATRALTKHEQGLMEAAKTRHKGGIGAPQTQMGRTFGGDAFLPSPAVVEFKDFDVGRTVSASVQIINRSYKKNTFRVTGIPVEYCDVLDFAYKLPGYLAPGVSGEVVISFTPKAPVDIDTSLQLLADTGPFEVPIRCRTKRAALSVSPSAVDFGAGVTLGECATRTFTIANDGALEVEFRLDSPQLSEDERALLKSTANMAHLMTSATVAAAAAAAAATASGQGPRSARSFANMGVADGAAPETDTGPLVAPREERRLAHGGFTVFPCVGHLKGYSKVTFTVTFAPVVAAPAKLLLHASYKAPAMKRLALPHHEVTLTGTGRDVPVYVERPLIDFQCCMLGHLYRDVLVVRNGGKSAMKVMVVPRPELEGFFEFSPDFGFVQAGDSFPITIRFKPTPALLHACRKHVVEPEEEQILEIGMRLSVPDQSLPVPFTLRAQITNTDLLFQPPALDFGDCVMGERTAVKLLVRNPGRLPQTFGFVGLPSGLHFTPNDGFGYVLPGEALERLVSFQPPIAGPQTFSITAKTLAGRSFTLPCRANGVAPPVVLSSNRVRMPATPIGDTRTVSVVLINKTDQPQSYEFAVPADSDLTLSPHVGRVPPQSRLRVQIDYSPRPPVDGEQQGALPPPSAPNTARGPRDGGGGGAMANGNGSGGYEHYNDDGEPEDGEGDADGHTDTDSFQSPSARASPVQPLGRGGRGGRGGAAGEDEDEDEDAGELPVRGKSSSSSKASSGRRSSSPQLGGRQGLAMGRINEVPDDDDADAEAEAAAEAEQRTALAALKRIQSMGGGDPGWYRWREHAITCYIKPQSQNPTPSQSQSGQAPAASAPSDGASGAAAAAETAASSGPAAAPPPQEIHLQVATCAVLPDLVLLAPPDLPYVPLHQCHCLDFGPVPVGQRVVRRLELANEGEEPLVLGAESMDSREVFGLVNALRPVRPGASFRVMVSFTPQARTEYLEVLVLKSARTRLRLALKGAGIAPELQLGPEGVTATGLDMGDVLVGEAAARTLTVTNVCPFPLSFTMRLAGKASAADPNPTMRQAFSCHPAEGTLAQGESCEVAVSFTPFSQRPYFEDVLQVVVPNQQDQLLVPLRGRGWREAVFVAGPDYPEPQPDPFLLHHLAKQAGVALPPSVSGGGAAAGGAAVAAAAAGDKPSTPAPGIKPPATPPGGASKGKAAAAAAAAAAAAAAGASEPRELTLNFPHAIYPGEVATASFDVGSLKSTASGSAPGEVGVAELPAEAREAGWAVTDPPTAGAGGGGKVPLAAGERKPITLSYSAPAAPHPGMVAAYGHAEYRVLKLQLTLKGGLAALSGGPEGRKVVVAARCRLLPGSRPPGEPVPPGVTPAPEPVAASGPGAGAAGVKKLVPPPSPPKKAV
Protein: K Homology domain-containing protein (Q17936)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- K Homology domain-containing protein
- Poly
- Ankyrin repeat and KH domain-containing protein mask-1
- K Homology domain-containing protein
- Probable splicing factor, arginine/serine-rich 7
- RRM domain-containing protein
- K Homology domain-containing protein
- LUC7-related splicing factor homolog
- Branchpoint-bridging protein
- Protein SWAP
Sequence:
MSFVYEFSRFQFIPTQFFLSISQYLFNRIDKLITIHHLESLISLFSDSLPAKRPADDTDLNPFMDDNEAVNEKYPIPESAVGIVIGRGGSEIQGIQAKAGCRVQMSPDADPSSGVRMVTLEGSRSNVETAKHLINEVVARSQNPRPQYGFPRAQTTIDIAIPPNRCGLIIGKSGDTIRQLQEKSGCKMILVQDNQSVSDQSKPLRITGDPQKIELAKQLVAEILNSGGDGNGGSGLQMHHAGGGGGASARGEVVVPRSSVGIIIGKQGDTIKRLAMETGTKIQFKPDDDPSTPERCAVIMGTRDQIYRATERITELVKKSTMQQGGGGNVAGAMVSNEASTFYMSVPAAKCGLVIGKGGETIKQINSESGAHCELSRDPTGNADEKVFVIKGGKRAIEHAKHLIRIKVGDIAPNTPFRDDSAMTMQTQFSAPAQNNFGGQQQWNPVAQIPAAAQNPYQVGGWQQNSVYAQQTAAPAAAPYAAAGIVQPQQQVAYQQPQVVQQVQPATTVAATTTPTVDPVTGEQDYSAQWMEYYKSIGAHDKAEAVEAQMKKKKAEAAARAVVPGGLIQQMPMGMAMPQMSAQARVPTQNYPAYSAAGAAPYQAQQYGQYQ
Protein: Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7) (Q9BYR0)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MVSSCCGSVCSDQGCSQDLCQETCCRPSCCQTTCCRTTCYRPSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCCMSSCCKPQCCQSVCCQPTCCRPSCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC
Protein: Uncharacterized membrane protein C20F10.07 (O42976)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Localizes to cytoplasmic punctate structures. {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Calcium-channel protein cch1
Sequence:
MKEENGFAGFLNTAVNRLSGVLNDTAPTKSQSLKNGVNNEGNRGFSLFRNPRFMSDEKLSSEASSHSTLGQQQARDGRQSPSKEAPFGEGELKLENFENQENEADEAENEETSYSEQNHTENTEEIAEESRPLERTHSGSNHHEASSTGHLNLPPLENTLSQGSAITAPSRKVSITSSNGVSARLSGYAFANSKRNRDFHRIFKVLPPEDHLIDDYGCALQRDIFLHGRMYLSESHICFNSSIFGWVTNIVIPVTEIVSVEKKSTAVVFPNAIQITTLHARYIFASFISRDTTYQLIIAIWKNTHPFLTTLANGHGVMDASGNHHSGSSNQSINADSSAGSEGVDEGTSTEANDESSEDDDEDNNTDEANEDAQSNVSDESPKGEGSSHSDNVVLSDGNSVKKMNEDGADTSLLSVSEVTSHPPTEWTGSPLAHVLCSDVVNLSVSTVFNLLCGSDTTWIINFFKSEKLTEIKIGKWEKIDDKWNRKVQYIKPVAPPYRQTSCYITDTIQHLDINNYIEILSTTSTPDVPSGTSFVVKTLYALSWAHSSKTKLNISYSVEWSKSSWLKGPIEKGAQEGQASYVKDLLTAFENYKVSPKGRRKKITKHTKKKNKHASETSVAPEKVDNSSIEQSSSFLTKLYTFPFTIITWLMHPTHLLLVVMFSMLVLQWWYMQQILHAELPSTSSRSDSSRDLDFDHIPMDDTAFKLWITSRLDSVERDRDFVYENSDPNLEHGKIKIATDYMERRLKKLKERLRKLEASGYI
Protein: Aspartyl protease APCB1 (EC 3.4.23.-) (Aspartyl protease cleaving BAG 1) (Q9M9A8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in proteolytic processing of BAG6 and plant basal immunity.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- BAG-associated GRAM protein 1
- Aspartic proteinase A3
- Membrane-associated progesterone-binding protein 4
- BAG family molecular chaperone regulator 6
- Eukaryotic aspartyl protease family protein
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH11
- Aspartic proteinase A2
- RING-type E3 ubiquitin transferase
- Serine carboxypeptidase-like 34
- BAG family molecular chaperone regulator 7
Sequence:
MEPDLHDQQQQQRVHSVVIITLPPSDDPSQGKTISAFTLTDHDYPLEIPPEDNPNPSFQPDPLHRNQQSRLLFSDLSMNSPRLVLGLLGISLLAVAFYASVFPNSVQMFRVSPDERNRDDDDNLRETASFVFPVYHKLRAREFHERILEEDLGLENENFVESMDLELVNPVKVNDVLSTSAGSIDSSTTIFPVGGNVYPDGLYYTRILVGKPEDGQYYHLDIDTGSELTWIQCDAPCTSCAKGANQLYKPRKDNLVRSSEAFCVEVQRNQLTEHCENCHQCDYEIEYADHSYSMGVLTKDKFHLKLHNGSLAESDIVFGCGYDQQGLLLNTLLKTDGILGLSRAKISLPSQLASRGIISNVVGHCLASDLNGEGYIFMGSDLVPSHGMTWVPMLHDSRLDAYQMQVTKMSYGQGMLSLDGENGRVGKVLFDTGSSYTYFPNQAYSQLVTSLQEVSGLELTRDDSDETLPICWRAKTNFPFSSLSDVKKFFRPITLQIGSKWLIISRKLLIQPEDYLIISNKGNVCLGILDGSSVHDGSTIILGDISMRGHLIVYDNVKRRIGWMKSDCVRPREIDHNVPFFQG
Protein: Uncharacterized protein C16C4.16c (O74460)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Elongation factor 3
- mRNA export factor elf1
- Uncharacterized mitochondrial carrier C1604.04
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL13
Sequence:
MDIVAETQIEEESLIPDATSTPLETEVVADTTLRKTALHLAGVDNLSEEQVKGFISAYAPESQCTIEWINDNECNVVYADDDVSRNALFHLIMESPTEFSEELEYQTKPHPTVPTCQFKIRYARYGDKKVKSAHLYSRYYLFHGDPREEKAQKSKSKSRNQDERGSPLDERLGPKVSDLTLMERIFQVRRKPRKSRRDRRSRVSKR
Protein: Candida glabrata strain CBS138 chromosome I complete sequence (Q6FQ10)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome K complete sequence
Sequence:
MFSNVINFCFWLTLFLTVGTAKNPVDFPNLCQYPNLDGAVAGFDTEIYNADPSILINFSLWPILQFPKEWHKTIGRAITTQTNFKLPASDTTLFGVSIPTQNILIEFRGYFIPPKSGTYTFALYLTDDGSAMFLGNDAAFPCGNITSWSNPTNDQVSVSDYDPKKKTLTVYMVAGVAYPLRIAYYNREKGGSLTASFVDPDGLTHSDWNGYIWTLPSCDNCKYSPPPMETTTTSSAYVLEKTTSTIFSIYTGVDGEPTPHTLVKVIVPTVTEYIVVPSPTTITTTKNVDGQQLVEQDVISFFSTTNSIGKPITGSTTITIDDGRDKTTTYKDKDGSIHTDIISHITKLDENGMPVVILTRYPAPAPAPGPGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSEGGSGEGGSGGSNPVDDGKDKTTVVTDKDGHVHTDIISHITTTDKDGKPTVILTQYQSPTPSPGEGGSGSEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSEGGSGEGGSGGSNPVDDGKDKTTVVTDKDGHVHTDIISHITTTDKDGKPTVILTQYQSPTPSPGEGGSGSEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSEGGSGEGGSGGSNPVDDGKDKTTVVTDKDGHVHTDIISHITTTDKDGKPTVILTQYQSPTPSPGEGGSGSEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSEGGSGEGGSGSNPGTGEGGSGSNPGTGEGGSGSEGGSGEGGSGGSNPVDDGKDKTTVVTDKDGHVHTDIISHITTTDKDGKPTVILTQYQSPTPSPGEGGSGSEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSNPGTGEGGSGSEGGSGEGGSGGSNPVDDGKDKTTVVTDKDGHVHTDIISHITTTDKDGKPTVILTQYQSPTAAQDGTSKTITVDGEEIIEVVHITTYTDSDGHTITSTYTEMFKTLIDAEPQYVSETTQTITTTDAEGHTTTITTTYTIDNNGNAVPIVPSSSSMSSSSSSSMSSSSSSSMSSSSSSIISSSISSAISTPSGQDYTITTTGSDGKIETDIVSHITTTVNGKPTTITTTVPCDVSTGKDRTTTVTHSNGVIETNVVSHITTTVNGKPTTITTTVPCDVSAGKDRTTTVTHSNGVIETNVISHITTTDSNGKPTTITTTTTKLNNAHTTTLTNKDGSVDTKTVVGVTTTNQFGQPVITSITYTPKADSHSNSNVGTVAGTKGAAGNNPSGTNKPQTKPTANAGSNGASPAANAGSNGASPAANAGSNGASPAANAGSNGASPAANAGSNGASPAANAGSNGASPAANAGSNGASPAANAGSNGASPAANAGSAVAPKASASNSAAVQQQSSASGRNPGASAAPTIQQINKNAASSMKQTKIGVTTVLTILLFTLF
Protein: Stromal interaction molecule 1 (E9PNJ4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMSRAADEALNAMTSNGSHRLIEGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTRIPHLAGKKAVAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
Protein: Ureidoglycolate dehydrogenase (NAD(+)) (EC 1.1.1.350) (P77555)
Organism: Escherichia coli (strain K12)
Function: AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- (S)-ureidoglycine aminohydrolase (UGHY) (UGlyAH)
- Ureidoglycolate lyase
- Allantoate amidohydrolase
- Oxamate carbamoyltransferase subunit AllF
- Allantoinase
- Oxamate carbamoyltransferase subunit AllG
- HTH-type transcriptional activator AllS
Sequence:
MKISRETLHQLIENKLCQAGLKREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGGTNREPEFRLEETGPCSAILHADNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAISYFVQQAARAGFIGISMCQSDPMVVPFGGAEIYYGTNPLAFAAPGEGDEILTFDMATTVQAWGKVLDARSRNMSIPDTWAVDKNGVPTTDPFAVHALLPAAGPKGYGLMMMIDVLSGVLLGLPFGRQVSSMYDDLHAGRNLGQLHIVINPNFFSSSELFRQHLSQTMRELNAITPAPGFNQVYYPGQDQDIKQRKAAVEGIEIVDDIYQYLISDALYNTSYETKNPFAQ
Protein: Sterol uptake control protein 2 (Mannoprotein regulation by oxygen protein 4) (Q12151)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Lanosterol 14-alpha demethylase CYP51
- C-8 sterol isomerase ERG2
- Delta
- Sterol 24-C-methyltransferase ERG6
- Sterol regulatory element-binding protein ECM22
- Squalene synthase ERG9
- Transcriptional activator/repressor MOT3
- Squalene epoxidase ERG1
- Farnesyl pyrophosphate synthase
- ATP-dependent permease AUS1
Sequence:
MSEVGIQNHKKAVTKPRRREKVIELIEVDGKKVSTTSTGKRKFHNKSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYTPIHLRKGRGATVVKYVTRKADGSVESDSSVDLPPTIKKEQTPFNDIQSAVKASGSSNDSFPSSASTTKSESEEKSSAPIEDKNNMTPLSMGLQGTINKKDMMNNFFSQNGTIGFGSPERLNSGIDGLLLPPLPSGNMGAFQLQQQQQVQQQSQPQTQAQQASGTPNERYGSFDLAGSPALQSTGMSLSNSLSGMLLCNRIPSGQNYTQQQLQYQLHQQLQLQQHQQVQLQQYQQLRQEQHQQVQQQQQEQLQQYQQHFLQQQQQVLLQQEQQPNDEEGGVQEENSKKVKEGPLQSQTSETTLNSDAATLQADALSQLSKMGLSLKSLSTFPTAGIGGVSYDFQELLGIKFPINNGNSRATKASNAEEALANMQEHHERAAASVKENDGQLSDTKSPAPSNNAQGGSASIMEPQAADAVSTMAPISMIERNMNRNSNISPSTPSAVLNDRQEMQDSISSLGNLTKAALENNEPTISLQTSQTENEDDASRQDMTSKINNEADRSSVSAGTSNIAKLLDLSTKGNLNLIDMKLFHHYCTKVWPTITAAKVSGPEIWRDYIPELAFDYPFLMHALLAFSATHLSRTETGLEQYVSSHRLDALRLLREAVLEISENNTDALVASALILIMDSLANASGNGTVGNQSLNSMSPSAWIFHVKGAATILTAVWPLSERSKFHNIISVDLSDLGDVINPDVGTITELVCFDESIADLYPVGLDSPYLITLAYLDKLHREKNQGDFILRVFTFPALLDKTFLALLMTGDLGAMRIMRSYYKLLRGFATEVKDKVWFLEGVTQVLPQDVDEYSGGGGMHMMLDFLGGGLPSMTTTNFSDFSL
Protein: Basic leucine zipper 23 (AtbZIP23) (bZIP protein 23) (Q8GTS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in the response to zinc ion deficiency. Binds to the consensus sequence 5'-[AG]TGTCGACA[CT]-3' also called zinc deficiency response element (ZDRE). The ZDRE sequence is conserved in the plant kingdom and present in the promoters of genes that constitute the primary response to zinc deficiency, comprising additional ZIP metal transporter genes. Required for zinc accumulation in roots. Mediates the expression of the zinc transporter ZIP12 during growth in zinc-deficient conditions. ZIP12 transporter is involved in zinc uptake in roots.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:26306426}.
Interaction partners:
- TPR repeat-containing protein ZIP4
- Basic leucine zipper 8
- Zinc transporter 9
- Nicotianamine synthase 2
- Nicotianamine synthase
- Probable zinc transporter 12
- Nicotianamine synthase 3
- Zinc transporter 4, chloroplastic
- Probable nicotianamine synthase 4
- Nicotianamine synthase 1
Sequence:
MDDGELEFSNSNMGGELPSCSMDSFFDELLRDSHACTHTHTCNPPGPENTHTHTCLHVHTKILPDKVSTDDTSESSGKKRPLGNREAVRKYREKKKAKAASLEDEVMRLKAVNNQLLKRLQGQAALEAEVTRLKCLLVDIRGRIDGEIGAFPYQKPAVTNVPYSYMMHPCNMQCDVDNLYCLQNGNNGEGASMNEQGLNGCEFDQLECLANQNLAGKEIPVCSNGIGTFTVNGSGVNKRKGEPRAAKAV
Protein: TBC1 domain family member 2B (Q9UPU7)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein that plays a role in the early steps of endocytosis.
Subcellular location: Early endosome {ECO:0000269|PubMed:32623794}.
Interaction partners:
- Ras-related protein Rab-31
Sequence:
MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLKAPNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNASAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGHNDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKGKRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSSQKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVARDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIESKYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARKLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEEEDT
Protein: Candida glabrata strain CBS138 chromosome J complete sequence (Q6FPE4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRNFVALILALFFALASLVLACIACAGSTKNYYPINQIFCAQLDLSNLDIATVIPAASSFSISDLGLPKFINIGLWSYCVASSSTDVTSCTSPNGIQTFNLKNLLKDNIENNQVLQLVDDVAKIVLPQQLQDKLVYYNNLVKCMFITLIIGIVLTFLNLVINVLRWFLHFSFVNFVGGFVCFLSFASLLISVGTNMGTYIYIRHILNKNYSDYGIHLSLGRKFLALLWAAVVAALLNLFCWMTVRQRKKVVYVHQPYNDKY