wanglab/gogpt-training-data huggingface dataset:
Protein: Dachshund, isoform D (Q8IP20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSVTSEQSENNNNKAGAINNNINSGIERAAGNMNTTAMLMHHQQQQQAAAAAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPRSYNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPESSRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPGMPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGSAAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPASSTETLLRNIQSLLKVAADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQLGGGSGAVKGSPNANGSGGGGSGSACSESEACGGGGGDAKCNNNNNNNNNNNNSNSSSHGGDVETMKENDAGSEKSDKSLASNSSCDVTAGHSAGSVSGSISAGLNCPDSPTHFKREPSSDHEGSVERQPRSSAASLAAHDEDNTKRCGSRDRDERPPSGSAASVAAEGSLAAAAAAAAAAAAAAASNGKGPWSYPGIDLMATGAFWQNYSESLAQELEMERKSRAANAERDVKSPLSERPTAYYKNSVLFGSAN
Protein: Protein phosphatase 2C-related protein (TipA) (Q94489)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MDSLLKEDEARIIENKIRDLNLGILSTKPKGIEYLQSDEIIDWISRILNISRAKAIEYGQLMWDRGVLEIIGLPFGDNSQLFFIKPTTAQTAAALAASNDEQSWNRLKSEASNKDMSQANPIYKLHKSIEKATKVYQSLLREKKQSTPPNTHLGLKLLDVCLNLIMSNSKPNPQYYQVLNMLQDFQSLPCDESDNAYLNPIASSDIDLSGGGGGGGGGGGGGLSTAKLQQEQNEIDELILQSEKLEKSLNEQIALVHNQTLQLKKMIEKKQHQLNSVKSGNTNSSNNNNSNNNNNNNISNVISYEKPTTIYPNGFEDHNSISLDRVKSQSNMGSLRGIDLAPVVIGSVQNQFPKFLIVDPKNDTFTSTINGPSADALESTFHSCFNNNFYARTISTYPHLPNHPKREGDPICDHFCVQIQASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKALSSEIQTVQDAGNHILSAFNYAHNRIVEGKSDIWEAGTTTLLGGVLVELQQSEASKPEPSSQLGRSGVNKPVIGANFANLTGSGIVSNGLSASVNNAGSIVKDINAPPSKWGFICASVGDCKAFHYSASSKKFTDITKNNRGNVDDPKDPGGRLGPYVANGQPDLRNLCLHFLPCNENDIIVLISDGVHDNLDPQTVGWTPRDLQLNYENWSDMEPDKALEAKTKYTQEFLKKKLRTHDQEQDPITAKFITEKLVEHCVETTKSSREFMVNFPNKPLPDNLKEYKGKMDHVTCVAFKVGKHAL
Protein: Superoxide dismutase [Fe] (EC 1.15.1.1) (FeSOD) (C6KT71)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Superoxide dismutase
- Aconitate hydratase
- Ribosomal protein L13
- Large ribosomal subunit protein uL29m
- Mitochondrial ribosomal protein L46, putative
- 40S ribosomal protein S11, putative
- Mitochondrial ribosomal protein S5, putative
- Mitochondrial ribosomal protein S35, putative
- 30S ribosomal protein S2, putative
- Mitochondrial ribosomal protein L11, putative
Sequence:
MNLKILLCSSIFLFFLKPNVPKGAYGLKNVCKLNFLNFNGFLPLYKTNKYFSKHDENLYESWDVKPLWNAKPFSLMKLPFNPQDMSPFLSEEAIKYHYSKHHATYVKNLNNLSEQHKDLKSLTLEDIIKKYDGSIHNNAAQIFNHNFFWLGLKEQGGGMPYGEIKEKLDESFNSFENFKNEFIKQASGHFGSGWIWLIIKDRKLEIFQGHDADSPIKQNIGKPILTLDIWEHSYYVDYKNSRADYIKEWFNKINWDFANYNLSISS
Protein: Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT) (Q8BN82)
Organism: Mus musculus (Mouse)
Function: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (By similarity). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (By similarity). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NRA2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18695252}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NRA2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRPLLRGPAGNDDEESSDSTPLLPGARQTEAAPVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHHGHRN
Protein: Transferrin (Q9VWV6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ferritin
Sequence:
MMSPHKTHTWLPLAVAALLLILGPQSSLAEEPIYRLCVPQIYLAECQQLLADPSEAGIRMECVAGRDRVDCLELIEQRKADVLATEPEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKDSPIRTLQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATERELKSLSEFFTQSCLVGTYSTHPETDRLLKKKYANLCALCEKPEQCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKYFGLPGAGPDAPPAEGNPENFEYLCEDGTRRPVTGPACSWAQRPWSGYISNEQAVHNSEQLHQLQSRLERFFANGLQAQNKDAAAHLLIQPNAVYHSKDAAIDPKVYLERAGYKDVIERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTDCVVALTKKEADLTIVRATGYADARSNQLQPIVYEQRAQDDVLVAVAAPGVTREALQKASIKFNENCERSRAAAALLNKRRGLDACRVSSSDDGEVQIVPASELEKHKDAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDKFGARGKLVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIYTDLQCNANKIAKQ
Protein: Tyrosine-protein kinase fynb (EC 2.7.10.2) (Proto-oncogene c-Fynb) (F1RDG9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- SHC adaptor protein 3.
- SHC-transforming protein 1
- Tyrosine-protein kinase yes
- Caveolin
- Caveolin
- Catenin
- Catenin beta-1
- Catenin, beta 2.
- Caveolin
- SHC-transforming protein 2
Sequence:
MGCVQCKDKEAAKLTDDRDTSLSQSGVGYRYGVDPTPQHYPAFSGTGTAVAAIPNYNNFHGAAVSQGMTVFGGISTSTHQGTLRTRGGTGVTLFVALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDSGGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQDCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQPGDNL
Protein: Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (Q8K1S3)
Organism: Mus musculus (Mouse)
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19492039, ECO:0000269|PubMed:21673655, ECO:0000269|PubMed:25374360}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08722}. Membrane raft {ECO:0000250|UniProtKB:O08722}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:O08722}.
Interaction partners:
- Netrin-1
- Neogenin
- Leucine-rich repeat transmembrane protein FLRT3
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Netrin receptor DCC
- Tyrosine-protein phosphatase non-receptor type 11
- Roundabout homolog 4
- Netrin-4
- Death-associated protein kinase 1
Sequence:
MRARSGVRSALLLALLLCWDPTPSLAGVDSAGQVLPDSYPSAPAEQLPYFLLEPQDAYIVKNKPVELHCRAFPATQIYFKCNGEWVSQNDHVTQESLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSSGTTKSRRAYIRIAYLRKNFDQEPLAKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPAQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTVCPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCVLNQRTLNDPKSHPLETSGDVALYAGLVVAVFVVVAVLMAVGVIVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPNNPQLLHPSAPPDLTASAGIYRGPVYALQDSADKIPMTNSPLLDPLPSLKIKVYNSSTIGSGSGLADGADLLGVLPPGTYPGDFSRDTHFLHLRSASLGSQHLLGLPRDPSSSVSGTFGCLGGRLSLPGTGVSLLVPNGAIPQGKFYDLYLHINKAESTLPLSEGSQTVLSPSVTCGPTGLLLCRPVVLTVPHCAEVIAGDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEAKSCHILLDQLGTYVFMGESYSRSAVKRLQLAIFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLLFKDSYHNLRLSLHDIPHAHWRSKLLAKYQEIPFYHVWNGSQRALHCTFTLERHSLASTEFTCKVCVRQVEGEGQIFQLHTTLAETPAGSLDALCSAPGNAITTQLGPYAFKIPLSIRQKICSSLDAPNSRGNDWRLLAQKLSMDRYLNYFATKASPTGVILDLWEARQQDDGDLNSLASALEEMGKSEMLVAMATDGDC
Protein: WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) (Q9Y484)
Organism: Homo sapiens (Human)
Function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity.
Subcellular location: Preautophagosomal structure {ECO:0000269|PubMed:21802374, ECO:0000269|PubMed:28561066}. Cytoplasm {ECO:0000269|PubMed:21802374}. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy. {ECO:0000269|PubMed:21802374}.
Interaction partners:
- Autophagy-related protein 2 homolog A
- Autophagy-related protein 2 homolog B
- OTU domain-containing protein 7B
- Ectopic P granules protein 5 homolog
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Gamma-aminobutyric acid receptor-associated protein
- Protein C19orf12
- Pantothenate kinase 2, mitochondrial
- Bifunctional coenzyme A synthase
Sequence:
MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
Protein: Raucaffricine-O-beta-D-glucosidase (Raucaffricine beta-glucosidase) (RsRG) (EC 3.2.1.125) (Vomilenine glucosyltransferase) (RsVGT) (EC 2.4.1.219) (Q9SPP9)
Organism: Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum)
Function: Glucosidase specifically involved in alkaloid biosynthesis leading to the accumulation of several alkaloids, including ajmaline, an important plant-derived pharmaceutical used in the treatment of heart disorders.
Interaction partners:
Sequence:
MATQSSAVIDSNDATRISRSDFPADFIMGTGSSAYQIEGGARDGGRGPSIWDTFTHRRPDMIRGGTNGDVAVDSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNNLIDGLLANGIKPFVTLFHWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRVKHWMTLNEPWTFSVHGYATGLYAPGRGRTSPEHVNHPTVQHRCSTVAPQCICSTGNPGTEPYWVTHHLLLAHAAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALDFMLGWFMEPITSGDYPKSMKKFVGSRLPKFSPEQSKMLKGSYDFVGLNYYTASYVTNASTNSSGSNNFSYNTDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYTKKTYNVPLIYVTENGVDDVKNTNLTLSEARKDSMRLKYLQDHIFNVRQAMNDGVNVKGYFAWSLLDNFEWGEGYGVRFGIIHIDYNDNFARYPKDSAVWLMNSFHKNISKLPAVKRSIREDDEEQVSSKRLRK
Protein: Crossover junction endonuclease EME1 (EC 3.1.22.-) (Q8BJW7)
Organism: Mus musculus (Mouse)
Function: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Subcellular location: Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells. {ECO:0000250}.
Interaction partners:
- Structure-specific endonuclease subunit MUS81
- Structure-specific endonuclease subunit SLX4
- Structure-specific endonuclease subunit EME2
- Structure-specific endonuclease subunit SLX1
- Exonuclease 1
- DNA excision repair protein ERCC-1
- Flap endonuclease GEN homolog 1
- DNA repair protein RAD51 homolog 1
- Fanconi anemia group D2 protein homolog
- Fanconi anemia group I protein homolog
Sequence:
MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD
Protein: UPF0213 protein YhbQ (P45472)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ
Sequence:
MTPWFLYLIRTADNKLYTGITTDVERRYQQHQSGKGAKALRGKGELTLVFSAPVGDRSLALRAEYRVKQLTKRQKERLVAEGAGFAELLSSLQTPEIKSD
Protein: Coatomer subunit beta (Beta-coat protein) (Beta-COP) (P41810)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for mitochondrial morphology.
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}; Cytoplasmic side {ECO:0000269|PubMed:14562095}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit alpha
- Coatomer subunit epsilon
- Coatomer subunit beta'
- Coatomer subunit zeta
- Coatomer subunit delta
- Coatomer subunit gamma
- ADP-ribosylation factor GTPase-activating protein GLO3
- ADP-ribosylation factor 1
- Protein transport protein BET1
- Conserved oligomeric Golgi complex subunit 3
Sequence:
MTSLSSQPAYTLVFDPSPSMETYSSTDFQKALEKGSDEQKIDTMKSILVTMLEGNPMPELLMHIIRFVMPSKNKELKKLLYFYWEIVPKLAEDGKLRHEMILVCNAIQHDLQHPNEYIRGNTLRFLTKLREAELLEQMVPSVLACLEYRHAYVRKYAILAVFSIFKVSEHLLPDAKEIINSFIVAETDPICKRNAFIGLAELDRENALHYLENNIADIENLDPLLQAVFVQFIRQDANRTPALKAQYIELLMELLSTTTSDEVIFETALALTVLSANPNVLVPAVNKLIDLAVKVSDNNIKLIVLDRIQDINANNVGALEELTLDILRVLNAEDLDVRSKALDISMDLATSRNAEDVVQLLKKELQTTVNNPDQDKAMQYRQLLIKTIRTVAVNFVEMAASVVSLLLDFIGDLNSVAASGIIAFIKEVIEKYPQLRANILENMVQTLDKVRSAKAYRGALWIMGEYAEGESEIQHCWKHIRNSVGEVPILQSEIKKLTQNQEHTEENEVDATAKPTGPVILPDGTYATESAFDVKTSQKSVTDEERDSRPPIRRFVLSGDFYTAAILANTIIKLVLKFENVSKNKTVINALKAEALLILVSIVRVGQSSLVEKKIDEDSLERVMTSISILLDEVNPEEKKEEVKLLEVAFLDTTKSSFKRQIEIAKKNKHKRALKDSCKNIEPIDTPISFRQFAGVDSTNVQKDSIEEDLQLAMKGDAIHATSSSSISKLKKIVPLCGFSDPVYAEACITNNQFDVVLDVLLVNQTKETLKNLHVQFATLGDLKIIDTPQKTNVIPHGFHKFTVTVKVSSADTGVIFGNIIYDGAHGEDARYVILNDVHVDIMDYIKPATADDEHFRTMWNAFEWENKISVKSQLPTLHAYLRELVKGTNMGILTPSESLGEDDCRFLSCNLYAKSSFGEDALANLCIEKDSKTNDVIGYVRIRSKGQGLALSLGDRVALIAKKTNKLALTHV
Protein: Mesoderm-specific transcript protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) (Q07646)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18644838}; Multi-pass membrane protein {ECO:0000269|PubMed:18644838}.
Interaction partners:
- Small nuclear ribonucleoprotein-associated protein N
- Growth factor receptor-bound protein 10
- Pleiomorphic adenoma gene-like 1
- Retrotransposon-derived protein PEG10
- Insulin-like growth factor 2
- Neuronatin
- Cation-independent mannose-6-phosphate receptor
- Epsilon-sarcoglycan
Sequence:
MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKTSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHQYSIFEQASIVESLLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPTESELWDMWAVIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPINPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF
Protein: Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Q9JII1)
Organism: Mus musculus (Mouse)
Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19668215}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10806194}; Peripheral membrane protein {ECO:0000269|PubMed:10806194}; Cytoplasmic side {ECO:0000269|PubMed:10806194}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Nucleus {ECO:0000269|PubMed:26051944}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000269|PubMed:10806194}.
Interaction partners:
- Phosphatidylinositol-3-phosphatase SAC1
- ADP-ribosylation factor-like protein 13B
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
- Inositol polyphosphate-4-phosphatase type I A
- Type II inositol 3,4-bisphosphate 4-phosphatase
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Inositol polyphosphate 5-phosphatase OCRL
Sequence:
MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSLWSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDPEHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS
Protein: FERM domain-containing protein 8 (Q9VBX0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEPNHYYCRSAMQQNPSTSIPQHASNKLNYGMNAGQDYVTCSSGQSQSGYSSKDLVPRSGNSKTLGGNGNMGSPYGGSVCSNSGQCSKNTANAGNYINIMTVPLGTLQYNRKKLSTQDYESHLYYNTTDVKCRDDYYIANNAAAAIPQHQAHQPHQQPHQHQHPQHQQQHQQHQQHQQHQQHQQHLHQQQQQQANFLHIQQSLQHNHQLSHPEPIHQLPQLQGTVADPPDAFDNCAIFPSAGGSSNGSGRVAATQTHQNPSGVVTCDQQVPVSLGSVNMPVPPIMYTVHRVVTTAQIQTAAGSTFASSASVSSVVSTGQNDGDCLSPAQVSSAMAASGNASCLGGLPDMGANMMSNASALCPLSDLRSPSGVLTNSSYMPQHHKCNNGNDAQSNPAIQKRLMATSSTSNFATAGKAASNLTRALQNVIPTCVYLMSRVAVHMEIEGTAQCPSQVMLAAALGCEELGISNKLLAQSVFGLWMTSALLEMQLKAHHCPYIVRVAWPNLLQKFSNSSPSDRKFDEPMIVLKRNVFFSKRDEEKIKDHRILELLYEEARNNVLTGRYIMEPVHSLMLGGIQARIELGPYNSHTHTIGFFRENQARFLPPHVAKSSTWLWLPISQKNSAEVKLLEQFKRVPQTATTRKLMRKYLEFCWALPFYGAAYFHGQIEQPVRGIMALVNQKDMEVLVAVNERGVFVIDPYECTLLLGLRYEDLSWDYAKPSASDDPECLTCIFLQFDAVENGIQVSKLMQIFSKQAAMIDALISHFTDQIRNKKQEGNTQEPFHDEPNPIQNNGNGVLCNKLSRLTLATFDEEGGRCIGQMGSLSISY
Protein: Interleukin-22 (Q5TLE4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cytokine receptor family member b4.
- Interleukin 10 receptor, beta.
- Interleukin 26
- Interleukin 17_1
- Interleukin 17_5
- Interleukin 17_2
- Interleukin family protein
- Interleukin-6
- Interleukin 13
- Interferon gamma 1.
Sequence:
MGDYAKGEKTTTVTYRHDIKAPEPQDALQVSTSRNNGVHKRTDTRIHSSTCDMKCFTLIALLCSCFLSGCARPTPLDSSATWNDLAAMTDTARNEDDHETRLLPYFSHDMLQEEGSCCINARILKYYVNHVLESDEHTDMKYPMIRNVREGLHRVEQELQNHCKHDYSSHPLVKQFKRNYHASAIMDLAAARNKAIGETNTLYHYLFESCTPK
Protein: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (P31214)
Organism: Rattus norvegicus (Rat)
Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).
Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- 17-beta-hydroxysteroid dehydrogenase type 3
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Aldo-keto reductase family 1 member C18
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- Polyprenal reductase
- Aromatase
- Aldo-keto reductase family 1 member D1
- Aldo-keto reductase family 1, member C1
- Estradiol 17-beta-dehydrogenase 2
- 17-beta-hydroxysteroid dehydrogenase type 6
Sequence:
MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPSFVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCIGNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRIPRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF
Protein: ErpC (Q44790)
Organism: Borreliella burgdorferi (Lyme disease spirochete) (Borrelia burgdorferi)
Interaction partners:
Sequence:
MNKKMKMFIICFIFALISSCKNHTLYDGQSNGEAKVKKIEFSEFTVKIKNKNNSNNWADLGDLVVRKEEDGIETGLNVGKGDSDTFAGYTATFFSLEESEVNNFIKAMTEGGSFKTSLYYGYKDEQSNANGIQNKEIITKIEKIDDFEYITFLGDKIKDSGDKVVEYAILLEDLKKNLK