wanglab/gogpt-training-data huggingface dataset:
Protein: Amino acid transporter, putative (Q389Z1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MHSVHESLLGDDAAARNTGRQSTINRISMLVAQRLSVVGMEEEVRHGSVAGASVNTLCNVIGAGVLSLPLAMHEASIVGGFTLMLFMALLGGLAAFMVIMGCEATQRFSFAEVVAHALFPSYTFEDFCTKVGKLALHDLGCVGGGAMETEELHRKHKEREAVSRRKRRAVIVLLELLVFINNYGTLIIYSRVIGDSIPPVVSSLLHTSGIIVTRTFWLVTSGVIFFLLSCVRHMDELKWTSFLGFITILYIVVIVVVRYVTSLQNPPYPDVDPAALEGINWCKISVNILRSVSTYSIAFSYHSNIPYFYRELRDRKPYTMLKSVYIAFPIVTVCYATTGFFGYLTFGTLVASPAAGGDIVRNYPADDLLVNIGRFGLFLHFACVYPILSVCARRGLHRVIMHALTWNRLSTPDEEDETPPANETTKYYSTDHRYKMSGGSDELPLSDDADRDVGSPEDTTTLAIVLEALFIVCTSVVLAAYISGISVVIDFLGTLLGTVMMFTVPGFTGWCILSRASPLGGSTVVSHTRLFMVLTFLLVVMGIACTSLGLLFLIKQYVLPAL
Protein: Fibrinogen beta chain (Fibrinogen, B beta polypeptide) (Q6NYE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibrinogen alpha chain
- Fgg protein
- Prothrombin
- Plasminogen
- Antithrombin-III
- Protein AMBP
- Heparin cofactor 2 isoform X2, member 1)
- Vitamin D-binding protein
- Alpha-1-antitrypsin precursor
- Alpha-2-HS-glycoprotein 1.
Sequence:
MKLVLLLCLCAVGALAQDDYDDYGEGKKEAKEVVDPRGHRPVSRGRETYSPGPVSQPPISGGTRYRGRPTAAPVGKAVQEKEEQPESGGCNHMSEKMGVLCPTGCELKKALIKQERNVKPTVEQLKRAVDDLTQSTNSIHGYVLDMTAEVAQRQKVSEGNGLVVDQYTDSLETQHAYIKDTVDVTFPQNIKVLQGVLDKIREKIQRLEKAITTQRAKCQAPCKVTCPIPVVSGKECEDIIRKGGEDSQMYIIRPDPLGTPYKVFCDQTSKNGGWVLIQNRMDGSVDFGRRWDDYRRGFGNIAFDVGKGHCQTPGEYWLGNDRISQLSKMGATELLVEMEDWSGSKVYAQYEQFSMQGEASNYILGVGRYSGTAGNTFLEGATELFGENRTMTIHNGMMFSTYDRDNDKWIPGDPSKQCSKEDGGGWWYNRCHSCNPNGRYYWGGAYTKYMAKHGTDDGIVWMNWKGSWYSLKTISMKIRPYFKQK
Protein: Major vault protein (MVP) (Lung resistance-related protein) (Q14764)
Organism: Homo sapiens (Human)
Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16441665}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:16441665}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16441665}. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
Interaction partners:
- Protein mono-ADP-ribosyltransferase PARP4
- Telomerase protein component 1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Poly [ADP-ribose] polymerase 1
- ATP-dependent translocase ABCB1
- Myeloid differentiation primary response protein MyD88
- Multidrug resistance-associated protein 1
Sequence:
MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR
Protein: E3 ubiquitin-protein ligase SPL2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SPL2) (SP1-like protein 2) (Q9SYH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses E3 ubiquitin-protein ligase activity.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:23118188}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Triglyceride lipase
- F20H23.8 protein
- Mitochondrial import inner membrane translocase subunit TIM22-3
- Argininosuccinate lyase
- YlmG homolog protein 1-1, chloroplastic
- 3-oxo-5-alpha-steroid 4-dehydrogenase family protein
- Chloroplastic import inner membrane translocase subunit TIM22-2
- Chloroplastic import inner membrane translocase subunit HP30-2
- Chloroplastic import inner membrane translocase subunit HP30-1
- Ubiquitin-like protein 5
Sequence:
MSSPERALLNLLTDIALSFDGAILGLTLAVSAVGSALKYASTNAALKKIKDAPEVSISDLRSLLPASEDKSETNDNRKSNDQRIVVVRGVVKPKISGDEGYKNNNVLISPETGDKALIIQRTQTYVYSGWKRLFQSTGHRFMLERSLRKHGADFTRTVPFVIVGKDQQSNSSFVAVNMDGSRQPLPLTTVYNRLQPINSSFLQAFLYPDYPVGLLDIEKILPPGKDITAVGIYSFNNGVPEIKSCQDLPYFLSEMTKDKMIEDLMEQTNFIFLGSVILGIVSVGILSYAAVRTWNKWKQWNHQRELPQRPNDSVVDDEPEDADEIPDGELCVICVSRRRVPAFIPCGHVVCCRRCASTVERELNPKCPVCLQSIRGSMRVYYS
Protein: Arrestin C-terminal-like domain-containing protein (I2HAB9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNFIRRFTISESFHQALFHQRDFPITSIMPTTQINIVLAEPRCMAGEFFNAKVLLDSSDPDTVVHSFCAEIKGIGRTGWVNIHTDKIFETEKTYIDTQVQLCDSGTCLPVGKHQFPVQIRIPLNCPSSYESQFGSIRYQMKVELRASTDQASCSEVFPLVILTRSFFDDVPLNAMSPIDFKDEVDFTCCTLPFGCVSLNMSLTRTAFRIGESIEAVVTINNRTRKGLKEVALQLIMKTQFEARSRYEHVNEKKLAEQLIEMVPLGAVKSRCRMEFEKCLLRIPDAAPPTQNYNRGAGESSIIAIHYVLKLTALPGIECEIPLIVTSCGYMDPHKQAAFQHHLNRSKAKVSKTEQQQRKTRNIVEENPYFR
Protein: RNA-binding (RRM/RBD/RNP motifs) family protein (F4IIL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAKTLDKSKKRKLVKSKSTNFDKKQKINKQQQQPESSTPYSSSSSSSDSSDSESDNEFDPEELRELLQPYSKDQLVDLVCSASRIGSSIYSAVVEAADRDVTHRKIFVYGLPWETTRETLVGVFEGYGEIEECTVVIDKATGKAKGFGFVMFKTRKGAKEALKEPKKRILNRTATCQLASMGPAASGKGHDQPGPVKISMGSMANHGQPQQQQVQGQHVFNGGGMAASPFMLGNQYHPLYGAGMLGNPALAAAAAAGGGYMYPMLAGALAHGGLGSDMVQSSQMGGIGVDPSVGAAGLSALGSYFRGQSLPSTYPDSDAGGKRGTGKDSDAGGSSFHGYSNYSWYVH
Protein: KAZ1-type serine protease inhibitor-like protein type epsilon (Kaz1-ORFB, isoform H) (O97042)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform A
Sequence:
MDWIKIFVSGLALLLIGMAQCYPQFDSENPWLRPRQPTEPTISPNAGGSTPANAAPPTTQSPRYFACFHSCPATSEYNPICGSDNVNYYNENKFNCALNCGLSEYIGCVPPQIPF
Protein: Nuclear fallout, isoform E (Nuclear fallout, isoform F) (RE24122p) (Q6NN29)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Midbody {ECO:0000256|ARBA:ARBA00004214}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004654}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004654}.
Interaction partners:
Sequence:
MSSQPASQPDSIDLAYDMWAGQFEFVGPTNQQSNKNSNNNNNNSNLNNNKCRIGAQQNRKLSTDSLEDLNLSFNTSASQNPLSNAYSLGVTGGAGSDYCGFGKHPPILIDQETFLSLNPADFEDIVPSNSEPNSLVFIENKLETNNNSLESNNNHINNNNNNKIYNLENLTSKFNNKTNNTNTNGFKLENLKNFKNKLLCDFEDTNSGGGGGGGSGGSGPVGMMNGALSAEICDNLNEQLELLQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYHMLEEQYRESELRAEERLAEEQKRHREILARVEREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQANDLHRTEEQLELARDQIGVLQQEHEEQAQALRRHEQEKKSTEELMLELGRELQRAREESGARAMPTTSPESIRLEELHQELEEMRQKNRTLEEQNEELQATMLTNQATMLTNGVEQGRHLLNGTLNSLAQELEEMSQAQLQQAFQEKEDENVRLKHYIDTILLNIVENYPQLLEVKPMERK
Protein: Calcineurin B-like protein 9 (Q9LTB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a calcium sensor involved in abscisic acid (ABA) signaling and stress-induced ABA biosynthesis pathways. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a negative regulator of stress and ABA responses. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF. The CBL9/CIPK3 complex acts in the regulation of abscisic acid response in seed germination.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16814720, ECO:0000269|PubMed:17922773, ECO:0000269|PubMed:19832944, ECO:0000269|PubMed:23335733, ECO:0000269|PubMed:23482856}; Lipid-anchor {ECO:0000269|PubMed:16814720, ECO:0000269|PubMed:17922773, ECO:0000269|PubMed:19832944, ECO:0000269|PubMed:23335733, ECO:0000269|PubMed:23482856}. Note=Plasma membrane localization abolished by 2-bromopalmitate (2-BP) treatment.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 23
- CBL-interacting serine/threonine-protein kinase 26
- CBL-interacting serine/threonine-protein kinase 1
- Potassium channel AKT1
- CBL-interacting serine/threonine-protein kinase 3
- Calcineurin B-like protein 1
- CBL-interacting serine/threonine-protein kinase 24
- CBL-interacting serine/threonine-protein kinase 8
- CBL-interacting serine/threonine-protein kinase 6
- CBL-interacting serine/threonine-protein kinase 11
Sequence:
MGCFHSTAAREFPDHENPVKLASETAFSVSEVEALYELFKSISSSVVDDGLINKEEFQLALFKNRKKENLFANRIFDLFDVKRKGVIDFGDFVRSLNVFHPNASLEEKTDFTFRLYDMDCTGFIERQEVKQMLIALLCESEMKLADDTIEMILDQTFEDADVDRDGKIDKTEWSNFVIKNPSLLKIMTLPYLRDITTTFPSFVFNSEVDEIAT
Protein: Protein phosphatase 1-binding protein Bifocal (Q962F2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004269}.
Interaction partners:
Sequence:
MESQKRPSLDLHTDVPAGLAAGGSGLGAAAEMSPTSGFLPDMPQWKKDLIQRRKTNVARTQAASITSPTDGSCGALAEANAAPGAIADFTEPATISSTSQKRNMIGSEEKSEKSSISNTNSDSTGGHHSVVAVSLSPDAAATTNVTVTPIPKQRSSLLNTRSQEREMVRYILSESGERDGELESGEQPAGVVSNSRCGEVETGTIGSPSSSANQNPNPNHLKTKCKPGQSVAEGKPSAKETIVDNSKSCSKTKSISDKLQSNKFIIQQQQQQQQQQQQQQQLSPTKVTVKPTMVAMQEMKKTTKQNGQHRHLAGKIGSVAGGDVDPQHPPTNPIPDSLDTGEDLSYGPGIVSKLRCRYLSLALRESRQQSSKQRLQRSTSLNTLLDRDDDEVEVEEPEMTNSQVRAKSTPPPILGAKPTPKPSSQHQRPVSLGANGAGSAVNPPSNSDQAQTGAVANGGAGSGQRSRHFKRGNEVMKRARSVEALLCEKSPWNSQRISTAGAAAAAAPSPPAPKATATAPSPVTSPTCVTIEDKIHNARERLHSGTDTAPPKRLTSIIDDTERPPPDLVKQTLKMFEASANRRPRAAHRSNGVGGVASKVANYKSIIKDQKQPSSAAATPPPTGMGFASSTPLRHVHPDIIPRQVDSPVSALSVMMRRMELQEPETPERETRDAEATPQSEALSETERNDRDEGDGEVDDDNHNNNDDDHDDGDDGSDNNEQRDKMGAAAAGDKPKPPAESAAGGAQRSFAASTENAHVASGSSSSTSASVRKLSNNNDSSSGPAVTKQIGVIRPLFNSQGAGSTPLTSREIEKNRINEMKKSTATDAGGSVSGSGTVAGAGSGTSPTTSLDSVINTKEAASSETDASASPLWTLRKLRNQSQTAGGGSGPSSSLHSTENTSMVFNFSKSTKEVPDYIESDVVIYRRKRELPKPNEPGFVLLGDLSVETSTDTDYDDYSMCPPSPCDVEFENANIVIDGKSSIRQKPKESSFRVQFNDTLTSTFEYPSEASMTIEDPPYADPFGHVSKHHQMLLAEQMHLLQHQEQLELEQMHQLGLAPEQHHHVTVDEIIELPTSTAGHGHGIGLGHRSGAAGGGGTMLGNLPLGSTALGFYTPMKGTAMDNLFQLGVTRYALPESSSSGSSNGSHSPGSNGSSPAGAAGSRLMFNGNGSIMGIGEGLIKEGDLAATEAGPGTADGAGASKKGSAVDEDDYHLTATPGAEVVYSEGTQKTDLLY
Protein: Cell division cycle 20.5, cofactor of APC complex (AtCDC20.5) (Q3E906)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:21687678}.
Interaction partners:
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 6
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 5
- Cell division cycle protein 27 homolog B
- Mitotic spindle checkpoint protein MAD2
- Mitotic checkpoint protein BUB3.1
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 7
Sequence:
MMNTSSHLKAQASCPLVEHFLRRKLSKENFDRFIPNRSAMDFDFANYALTQGRKRNVDEVTSASRKAYMTQLAEAMNQNRTRILAFRNKPKALLSSNHSDPPHQQPISVKPRRYIPQNSERVLDAPGIADDFYLNLLDWGSSNVLAIALGDTVYLWDASSGSTYKLVTIDEEEGPVTSINWTQDGLDLAIGLDNSEVQLWDCVSNRQVRTLRGGHESRVGSLAWNNHILTTGGMDGKIVNNDVRIRSSIVETYLGHTEEVCGLKWSESGKKLASGGNDNVVHIWDHRSVASSNPTRQWLHRFEEHTAAVRALAWCPFQASLLATGGGVGDGKIKFWNTHTGACLNSVETGSQVCSLLWSKSERELLSSHGFTQNQLTLWKYPSMVKMAELNGHTSRVLFMAQSPDGCTVASAAGDETLRLWNVFGEPPKTTKKAASKKYTDPFAHVNHIR
Protein: Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.99.28) (Cell division protein FtsW) (Cell wall polymerase) (Lipid II flippase FtsW) (Peptidoglycan polymerase) (PG polymerase) (P0ABG4)
Organism: Escherichia coli (strain K12)
Function: Peptidoglycan polymerase that is essential for cell division (Probable). Functions probably in conjunction with the penicillin-binding protein 3 (ftsI). Required for localization of FtsI.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00913, ECO:0000269|PubMed:11807049, ECO:0000269|PubMed:12423747, ECO:0000269|PubMed:9603865}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00913, ECO:0000269|PubMed:11807049, ECO:0000269|PubMed:12423747, ECO:0000269|PubMed:9603865}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, FtsQ and FtsL, but not FtsI.
Interaction partners:
- Cell division protein FtsA
- Cell division protein FtsL
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Cell division protein FtsQ
- Cell division protein FtsN
- Peptidoglycan D,D-transpeptidase FtsI
- Phospho-N-acetylmuramoyl-pentapeptide-transferase
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- DNA translocase FtsK
- Peptidoglycan D,D-transpeptidase MrdA
Sequence:
MRLSLPRLKMPRLPGFSILVWISTALKGWVMGSREKDTDSLIMYDRTLLWLTFGLAAIGFIMVTSASMPIGQRLTNDPFFFAKRDGVYLILAFILAIITLRLPMEFWQRYSATMLLGSIILLMIVLVVGSSVKGASRWIDLGLLRIQPAELTKLSLFCYIANYLVRKGDEVRNNLRGFLKPMGVILVLAVLLLAQPDLGTVVVLFVTTLAMLFLAGAKLWQFIAIIGMGISAVVLLILAEPYRIRRVTAFWNPWEDPFGSGYQLTQSLMAFGRGELWGQGLGNSVQKLEYLPEAHTDFIFAIIGEELGYVGVVLALLMVFFVAFRAMSIGRKALEIDHRFSGFLACSIGIWFSFQALVNVGAAAGMLPTKGLTLPLISYGGSSLLIMSTAIMMLLRIDYETRLEKAQAFVRGSR
Protein: Delta-5 fatty acyl desaturase (Q8QGE2)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQQTESSEPAKGDGLEPDGGQGGSAVYTWEEVQRHSHRSDQWLVIDRKVYNITQWAKRHPGGIRVISHFAGEDATEAFSAFHLDANFVRKFLKPLLIGELAPTEPSQDHGKNAALVQDFQALRDHVEREGLLRARLLFFSLYLGHILLLEALALGLLWVWGTSWSLTLLCSLMLATSQAQAGWLQHDYGHLSVCKKSSWNHKLHKFVIGHLKGASANWWNHRHFQHHAKPNVFRKDPDINSLPVFVLGDTQPVEYGIKKLKYMPYHHQHQYFFLIGPPLIVPVFFNIQIFRTMFSQRDWVDLAWSMSFYLRFFCCYYPFFGFFGSVALISFVRFLESHWFVWVTQMNHLPMEMDHERHQDWLTMQLSATCNIEQSTFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPLVRTLCEKHGVPYQVKTLQKGMTDVVRSLKKSGDLWLDAYLHK
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2) (Q7TMF3)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:38575788}; Matrix side {ECO:0000269|PubMed:38575788}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 alpha subcomplex subunit 13
Sequence:
MELVEVLKRGVQQVTGHGGLRGLLRVFFRANDIRIGTLVGEDKYGNKYYEDNKQFFGRHRWVIYTTEMNGKNTFWDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKFNVSATPEQYVPYSTTRKKIHEWVPPSTPYK
Protein: T. brucei spp.-specific protein (Q586D7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLPHSQPLVLPMEPSNWAVMPPTGVEMPMEPGTFEDISTAGWIGPRRRSFCGPQTEEEWEDLMIHRSSLRRESGQGTGVGLSGSGCLLGTDDPDRDVLCEYYGDMANRDEKVLSCGLRGQEGRRVLGNKPLRQRPNGPMRERTNYGSLASRRQRVMEEGGVWGDVEVCCVPVEPWHPMDMVCLGEERPEDVCVLRQTDTELYGTGRAFATDGKP
Protein: Adenine nucleotide alpha hydrolases-like superfamily protein (Expressed protein) (O82240)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetratricopeptide repeat protein SKI3
Sequence:
MATGDGKSVMVVGVDDSEQSTYALEWTLDRFFAPYAPNYPFKLFIVHAKPNAVSAVGLAGPGTAEVVPYVDADLKHTAAKVVEKAKAICQSRSVHGAVIEVFEGDARNILCEVVDKHHASILVVGSHGYGAIKRAVLGSTSDYCAHHAHCSVMIVKKPKIKV
Protein: Kinesin-like protein Klp98A (Q9VB25)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell. Also plays a role in regulation of autophagosome formation, fusion and positioning and is required for normal localization of Rab14.
Subcellular location: Early endosome {ECO:0000269|PubMed:26659188}.
Interaction partners:
- E3 ubiquitin-protein ligase Godzilla
- Kinesin associated protein 3, isoform G
- Ras-related protein Rab-14
- AP-3 complex subunit beta
Sequence:
MSSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQTHYEYEVRIALPDGKLNILRRYSRFRELHLCMKHCYGAKISALPFPRRELFASNSEPVAKHRRRLLELYLRRLFVVCSKIPQCPIYEGPGGTGLTRASLVQLSSFFKKGLFENGKHGTG
Protein: Mitochondrial carrier protein, putative (Q382A2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTTALRDECSPLQMYSELNPPVAIMAAVPAADMQPAETDNKPRQKSPSSHILASQLASAVSTTMFYPMDTLRIRYMSQDGTIQRQHNGQTYRSIYRAVGVIWKEEGLRALFRGCHVAVLGAVVAWGVYMFVYRKLCEVYNVSSFASRTGMSVVASVTSALLTTPIWLLKTRMQIECRAMGTCGSYSGFFKGFHHMLVTTGVRSLWRGASAQLLLVLPNSLGFPIYDSLKDCINQNIIGISAESCSWVHGRDLTVIEACLCSVVAKVFVVTLSQPFTMLKVRLQDQRWNQGEVRYMTIKQSIPLIIRREGVYGFTRGLASSLLYSVPRGVAYYVLYEKSLQFFSRRV
Protein: Tachykinin-like peptide-IX (P.nigriventer tachykinin peptides IX) (PnTkP-IX) (U29-ctenitoxin-Pn1i) (U29-CNTX-Pn1i) (P86306)
Organism: Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Subcellular location: Secreted {ECO:0000269|PubMed:15573368}.
Interaction partners:
Sequence:
QKKDKDRFYGLM
Protein: Protein ROOT HAIR DEFECTIVE 3 (EC 3.6.5.-) (Protein FRAGILE FIBER 4) (Protein SEY1 homolog 1) (P93042)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable GTP-binding protein involved in cell wall expansion. Required for appropriate root and root hair cells enlargement. May inhibit vacuole enlargement during root hair cell expansion. Plays a role in cell wall biosynthesis and actin organization. Seems to act independently from auxin and ethylene pathways. May regulate membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:14731265}; Multi-pass membrane protein {ECO:0000305|PubMed:14731265}. Golgi apparatus membrane {ECO:0000269|PubMed:14731265}.
Interaction partners:
- Reticulon-like protein B13
- microtubule-severing ATPase
- Putative RING-H2 finger protein ATL19
- Dynamin
- Phosphoinositide phosphatase SAC7
- RING-H2 finger protein ATL1
- Protein S-acyltransferase 24
- Protein RADIALIS-like 1
- Myosin-17
- Calcium-dependent lipid-binding protein
Sequence:
MDAACSTQLIDGDGVFNVSGVDHFIKEVKLDECGLSYAVVSIMGPQSSGKSTLLNHLFGTNFREMDAFRGRSQTTKGIWIARCAGIEPCTVVMDLEGTDGRERGEDDTAFEKQSALFALAVSDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLFSPRKTTLMFVIRDKTRTPLENLEPVLREDIQKIWDSVPKPQAHKETPLSDFFNVEVVALSSYEEKEEQFKEQVYNLRQRFFQSVAPGGLAGDRRGVVPANAFAFSAKQMWQVIKDNKDLDLPAHKVMVATVRCEEIANEKFSSFIANENWRELEEAVQSGPVSGFGRKLSSILQASLSEYDTEATYFEESVRSSKRQQLQEKLLQLVQPTFQDVLGHLRAGALENFKNAFEKALDAGEGFSSSAKSCAQSCISKFDKGCEEAVIEQAKWDTSKTREKLERDIEAHISSVRTAKLAELTTLYESKLNVALSGPVEALLDGANDETWPAIRKLLRREGELAVYGLSNALSGFEMDEETRSKMLADLENYARGIVETKAKEEAGRAMMRMKDRFATIFSHDSDSMPRVWTGKEDIRAITKMARSASLKLLSVMAVIRLDDELDNIEKTLTLALFNSTGNNATSKSISTIDSLASSTWEKVAPEKTLITPVQCKSLWRQFKNETEYTVTQAISAQEANRRNNNWLPPPWAILALVVLGFNEFMTLLRNPLWLLVLFVGYLVSKALWVQLNISGEFQNGVLPGLLSLSTKFIPTVMNLLKKLAEEGQAPPTNSNQSMNSTAQSEVTTNGESSSSSSSGSSPAKNVPIDTSA
Protein: Nucleoporin NUP133 (Nuclear pore protein NUP133) (P36161)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Interaction partners:
- Nucleoporin NUP84
- Nucleoporin NSP1
- Nucleoporin NIC96
- Nucleoporin NUP145
- Nucleoporin NUP49/NSP49
- Nucleoporin NUP159
- Nucleoporin SEH1
- Protein transport protein SEC13
- Nucleoporin NUP120
- Nucleoporin NUP192
Sequence:
MSEKKVHLRLRKELSVPIAVVENESLAQLSYEEESQASLMDISMEQQQLRLHSHFDNSKVFTENNRYIVKTLQTDYSSGFSNDDELNGYIDMQIGYGLVNDHKKVYIWNIHSTQKDTPYITVPFRSDDNDEIAVAPRCILTFPATMDESPLALNPNDQDETGGLIIIKGSKAIYYEDINSINNLNFKLSEKFSHELELPINSSGGEKCDLMLNCEPAGIVLSTNMGRIFFITIRNSMGKPQLKLGKLLNKPFKLGIWSKIFNTNSSVVSLRNGPILGKGTRLVYITTNKGIFQTWQLSATNSHPTKLIDVNIYEAILESLQDLYPFAHGTLKIWDSHPLQDESSQLFLSSIYDSSCNETYYILSTIIFDSSSNSFTIFSTYRLNTFMESITDTKFKPKIFIPQMENANDTNEVTSILVMFPNAVVITQVNSKLDSSYSMRRKWEDIVSLRNDIDIIGSGYDSKSLYVLTKQMGVLQFFVKENEETNSKPEVGFVKSHVDQAVYFSKINANPIDFNLPPEISLDQESIEHDLKLTSEEIFHSNGKYIPPMLNTLGQHLSVRKEFFQNFLTFVAKNFNYKISPELKLDLIEKFEILNCCIKFNSIIRQSDVLNDIWEKTLSNYNLTQNEHLTTKTVVINSPDVFPVIFKQFLNHVVFVLFPSQNQNFKLNVTNLINLCFYDGILEEGEKTIRYELLELDPMEVDTSKLPWFINFDYLNCINQCFFDFTFACEEEGSLDSYKEGLLKIVKILYYQFNQFKIWINTQPVKSVNANDNFININNLYDDNHLDWNHVLCKVNLKEQCIQIAEFYKDLSGLVQTLQTLDQNDSTTVSLYETFFNEFPKEFSFTLFEYLIKHKKLNDLIFRFPQQHDVLIQFFQESAPKYGHVAWIQQILDGSYADAMNTLKNITVDDSKKGESLSECELHLNVAKLSSLLVEKDNLDINTLRKIQYNLDTIDAEKNISNKLKKGEVQICKRFKNGSIREVFNILVEELKSTTVVNLSDLVELYSMLDDEESLFIPLRLLSVDGNLLNFEVKKFLNALVWRRIVLLNASNEGDKLLQHIVKRVFDEELPKNNDFPLPSVDLLCDKSLLTPEYISETYGRFPIDQNAIREEIYEEISQVETLNSDNSLEIKLHSTIGSVAKEKNYTINYETNTVEY