wanglab/gogpt-training-data huggingface dataset:
Protein: PROP1-like PPR domain-containing protein (Q4GYS4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 30S Ribosomal protein S17, putative
- Methyltransferase
- Dehydrogenase-like protein
- tRNA pseudouridine synthase A-like protein
- LysM domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Ubiquitin-like domain-containing protein
- ADP-ribosylglycohydrolase
- Uncharacterized protein
Sequence:
MLTPTRRLPKALSPYAQALRHVALRGATAFGPGAKEMELDMLRKGTLPADYRPPVQGRWDDTIERWAYAWQFPAEEEQDDITKSVERNASGMQALLEIGNKLLRSPPSPEPLSGKASKLYPPVGDMSSGNTALLPPNPTYDVLEQDVSELMAEDAVVVASQPRLRAEELSAKYNVPMAYIDDSSEASNASKSLALVMEDVGLEFTEDGLTVVISALSRQGYGTIGRAIFDFASTMGLGPSAEMYKALMKYASRRGDVNESMALIEEMKGNGITPRIGNWHELMYTFYKAKDYPAVSQIVDNMKMYANIEPNEVTFVLQLKALAKDNSQLNSLPEAIQLFDQMENVYGFIASRPHYDAMMFHLSQSPRPEMRLRCEELAHKMELMGIVWNANTYLNLIRSAQVVGDVAAVEKYLSRMREEGIPASIGHLTWAVQAHVQSMIRIDYDALKEKDESPLPTWLEHLETCFGIYELVVRRGWVMQLPFVNALLRLTCQATILSMERTPDEAETIGRFEEQANKIWNHTFDEWQLQKDVYSYECYIALLAHQQRIDEAEKLFQEMILKKDLSPSRRTYHCMIFMHLSSGEEGGTARALRYLEAMERAGIQVRPSLLKKIVRVNNAAGYKRDMKRRARRIMQAREEYLARKAEGVSFGEGGKEGASNQRADVDAEGNSILEPLAVSPTSTLAWWEKWKRETVSKHELFTEEGADGTPKGETFEEKNEALRMMGITSSFQTKDLVPQPDRQKLLPLIRREEGEIAGSLWAMDGGELSYPKDGGGPQGWGVRLWRERQLVKREYQKVLDGYRPVPQLSTLGNSVRTAGDQLDIERSGAQTPGELSDYRNFPDNRFDGGQLKPESEAAPAVPFSAELVWQGEANDKLSPYKSDEEIALENDNTFFSSLSKETEGKLSIAVKAMQNKEENSVDVRGKGVTRRSKFDYLEKWRDMYRHGTLEVPEGPTLNFGRTPDDHKETMAALVRGWYQRNRKEPASEEELKRWRVDEQRSSETSASRAALKKRKQVRSRHRNK
Protein: Importin subunit alpha (Karyopherin subunit alpha) (Karyopherin-60) (Serine-rich RNA polymerase I suppressor protein) (Q02821)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions in nuclear protein import as an adapter protein for importin beta nuclear receptors. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Together with importin beta KAP95, mediates nuclear import of transcription factor GCN4. Together with tethering factor STS1, targets the proteasome to the nucleus.
Subcellular location: Cytoplasm, perinuclear region. Note=Mainly localized at the periphery of the nucleus.
Interaction partners:
- Importin alpha re-exporter
- Nucleoporin NUP2
- Importin subunit beta-1
- Guanine nucleotide exchange factor SRM1
- Nuclear cap-binding protein subunit 2
- Ubiquitin-like-specific protease 1
- GTP-binding nuclear protein GSP1/CNR1
- U1 small nuclear ribonucleoprotein A
- Protein NAM8
- Exosome complex exonuclease RRP6
Sequence:
MDNGTDSSTSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIPPTDGADSDEEDESSVSADQQFYSQLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQNAGNTFGFGSNVNQQFNFN
Protein: Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) (Q66WM4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Phosphomannomutase
- Phosphoglucomutase, putative
- ATP-dependent 6-phosphofructokinase
- Mannitol-1-phosphate 5-dehydrogenase
- Glucosamine-6-phosphate isomerase
- Glucosamine-6-phosphate isomerase
- Fructose-1,6-bisphosphatase
- Hexokinase-1
- Phosphotransferase
Sequence:
MPPVPLLRLQCGVNSYDWGKVGHESAAAKYAATTAASDFSIQSDKPYAELWMGTHPSLPSKDLETQRTLLDMVQDNQALISQEVSERYGGKLPFLFKVLSIRKALSIQAHPNKKLAEKLHARDPRNYPDDNHKPEMTIAITPFEGLCGFRPLVEIIHFLKAVAPLRQLVGERAASEFENTVKGSEESEDPAVTEKNKQALRTLFTSLMRSSPESIEAATKELVAIAQNSPETFTTSSSTPETNPTNPAELAAITVRLNGQFPNDIGSFVFFFLNFVKLEPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLVDMLTYSYAPIAEQKLEPTDYPYAVLNAPAYSSGSSCILYDPPIEEFSVVKTDLKRQGAKATFDGISGPSIVICTAGAGKITVGPKTEEVNEGYVFFVGANAECIIESTGEDTFTTFKAFCDLTGKEDMVNGN
Protein: Uncharacterized glycosyl hydrolase Rv3401 (EC 3.2.1.-) (P9WN13)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Beta-phosphoglucomutase
- Uncharacterized glycosyl hydrolase Rv2006
- Trehalose-phosphate phosphatase
- Malto-oligosyltrehalose trehalohydrolase
- Trehalose synthase/amylase TreS
- Trehalase
- Possible acyl-CoA dehydrogenase FadE16
Sequence:
MITEDAFPVEPWQVRETKLNLNLLAQSESLFALSNGHIGLRGNLDEGEPFGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKIFRLLVGDEPFDVRYGELISHERILDLRAGTLTRRAHWRSPAGKQVKVTSTRLVSLAHRSVAAIEYVVEAIEEFVRVTVQSELVTNEDVPETSADPRVSAILDRPLQAVEHERTERGALLMHRTRASALMMAAGMEHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRPALRDQAAGALHGARYSGWQGLLDAQRAYLDDFWDSADVEVEGDPECQQAVRFGLFHLLQASARAERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLDLAKERAAELGLEGAAFPWRTIRGQESSAYWPAGTAAWHINADIAMAFERYRIVTGDGSLEEECGLAVLIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAAHNLHTAADACLRHPEAAEAMGVTTEEMAAWRDAADAANIPYDEELGVHQQCEGFTTLAEWDFEANTTYPLLLHEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRDSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHRNTRDGLHMASLAGAWTALVVGFGGLRDDEGILSIDPQLPDGISRLRFRLRWRGFRLIVDANHTDVTFILGDGPGTQLTMRHAGQDLTLHTDTPSTIAVRTRKPLLPPPPQPPGREPVHRRALAR
Protein: FeMo cofactor biosynthesis protein NifB (EC 4.-.-.-) (Nitrogenase cofactor maturase NifB) (Radical SAM assemblase NifB) (P11067)
Organism: Azotobacter vinelandii
Function: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
Interaction partners:
Sequence:
MELSVLGQNNGGQHSAGGCSSSSCGSTHDQLSHLPENIRAKVQNHPCYSEEAHHYFARMHVAVAPACNIQCHYCNRKYDCANESRPGVVSEVLTPEQAVKKVKAVAAAIPQMSVLGIAGPGDPLANPKRTLDTFRMLSEQAPDMKLCVSTNGLALPECVEELAKHNIDHVTITINCVDPEIGAKIYPDLLEQQAHPRRQGRKILIEQQQKGLEMLVARGILVKVNSVMIPGVNDEHLKEVSKIVKAKGAFLHNVMPLIAEPEHGTFYGVMGQRSPEPEELQDLQDACAGDMNMMRHCRQCRADAVGMLGEDRGDEFTLDKIESMEIDYEAAMVKRAAIHAAIKEELDEKAAKKERLAGLSVASVQNGTSGRYRPVLMAVATSGGGLINQHFGHATEFLVYEASPSGVRFIGHRRVDQYCVGNDTCGEKESALAGSIRALKGCEAVLCSKIGFEPWSDLETAGIQPNGEHAMEPIEEAVMAVYREMIESGRLENDGALLQAKA
Protein: PIAS3 protein (Protein inhibitor of activated STAT3) (Q6IAR4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHCSATPAPPPGRVSSIVAPGGALREGHGGPLPSGPSLTGCRSDIISLD
Protein: Dynamin associated protein 160, isoform D (M9ND00)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dynamin
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- AT02057p
- phosphoinositide 5-phosphatase
- Protein stoned-B
- Cdc42 homolog
- Clathrin heavy chain
- AP-2 complex subunit alpha
- Amphiphysin
- Protein cappuccino
Sequence:
MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSEIKPDPGACSRRSKGIQRLWQQWRGCDIDQAAQHGDASNNKLRGIIQAVHITKRRDGQLMGCAYVRFECNELLAKSMLQENGNQLVGKAVVVDWQPELPKKRFRQWRCW
Protein: Putative FAD-dependent oxygenase EncM (Q9KHK2)
Organism: Streptomyces maritimus
Interaction partners:
Sequence:
MQFPQLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPSSP
Protein: Microtubule-associated tyrosine carboxypeptidase 1 (EC 3.4.17.17) (Microtubule-associated tyrosine carboxypeptidase) (Q68EN5)
Organism: Homo sapiens (Human)
Function: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:35482892}. Note=Associates with microtubules. {ECO:0000269|PubMed:35482892}.
Interaction partners:
- Tubulin beta-3 chain
- Tubulin alpha-1B chain
Sequence:
MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGGTLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD
Protein: rRNA methyltransferase, putative (Q57Y21)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- rRNA processing protein, putative
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar complex protein 2
- Ribosome biogenesis protein NSA1
- Ribosome biogenesis protein NSA2 homolog
- Protein MAK16 homolog
- Pescadillo homolog
- Nucleolar protein, putative
- Nucleolar RNA binding protein, putative
- Ribosome biogenesis protein NOP53
Sequence:
MYRCRSAYKLLELDDKFSLFGGCCRTVVDLAAAPGGFSEVALQRMTAAEDVTSRPPVKPLVIAFDTRPMKAARDLHVVQCNINDHKRVIASVEEFIQRRGVGDGADRQVDVVLHDGVSVAKSHSAFSVTYAQNQMAVGALRLACALFLLSSQPAGTRQPPRAEDGLASSSKAEPQGPTFVTKAMRSAHFNQVLSAMKAYFRHVSVHRPAECNAASSETYVVARGFMSHARNRRNPLFLNQRQRLLSLPPFSEDVLPGRQIVWRCWGCHMYCMGAAPCINCSRVD
Protein: ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) (OSCP) (P13621)
Organism: Bos taurus (Bovine)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATPase inhibitor, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- ATP synthase F
Sequence:
MAALAVSGLSQQVRCFSTSVVRPFAKLVRPPVQIYGIEGRYATALYSAASKQNKLEQVEKELLRVGQILKEPKMAASLLNPYVKRSVKVKSLSDMTAKEKFSPLTSNLINLLAENGRLTNTPAVISAFSTMMSVHRGEVPCTVTTASALDEATLTELKTVLKSFLSKGQVLKLEVKIDPSIMGGMIVRIGEKYVDMSAKTKIQKLSRAMREIL
Protein: acylphosphatase (EC 3.6.1.7) (Q9LZF2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Aldehyde dehydrogenase family 3 member F1
- Aldehyde dehydrogenase family 3 member I1, chloroplastic
- Aldehyde dehydrogenase family 7 member B4
- Aldehyde dehydrogenase family 3 member H1
- Acetate/butyrate--CoA ligase AAE7, peroxisomal
- Aldehyde dehydrogenase family 2 member B7, mitochondrial
- Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal
- Aldehyde dehydrogenase family 2 member B4, mitochondrial
- RNA polymerase II C-terminal domain phosphatase-like 2
- Phosphoglycerate kinase 2, chloroplastic
Sequence:
MASIVGIRTRFLSFGKLSQISSSLLRIHNPRNHQNPLILPLPCFSAAPSRHRPLIWLRSSPPVSSMTTQAESGSSQQSDSSKTVRVVIKGRVQGVCYRNWTVENAEQLGIKGWVRNRRDGSVEALFSGPPEAVDEMHQRCRRGPPAAMVTGLEAFPSTEEPGSSFEYRSTV
Protein: Menin (Q9IAA9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGIRSTQKKHFPLRGIDGVVQLFESELNSPEPDLALLSLVLGFVEHFLAVNRVVPVNVPGVRFEPLQPDSLNSCFPTVELNLLSALYERFMAQIRGAVDMSQYRKPSGASSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSLITGTKLDSSGVAFAVVAACQVLGLKDVHLALSEDHAWVIFGKGGEETAEVTWHGKGNEDRRGQTVSAGINERSWLYLKGSYMKCNRNMEVAFMVCAINPSLDLHTDSTELIQLQQRLLWLLYDRGDLERYPMAMGTLADLEDQEPMTGKESPLSIHLKAVESAKKYYNNEHIYPYMYLAGYHYRHREVREALGSWAEAASVMQDYNYCREDEEIYKEFFDIANDVIPTLLKETAAAAESEGTDEAEKEDQPREAAALTALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATYLVQSLSRFDAQIRQKVSIITKDTEPVDDDDQSSEDLREGRRRGPRRESKLDEPAGSASPNPALPAQNQNPVPKKVGGEGGRRRSSASTRGKEADGKNEPSSPSPIPSPSQPPAVQGGPVVVFHSEKMKGMKELLSAAKVNSSAIKLQLTAQSQVQMKRQKPTASGDYTLSFMKRPRKTL
Protein: Gap junction beta-2 protein (Connexin-26) (Cx26) (P21994)
Organism: Rattus norvegicus (Rat)
Function: Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q00977}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29033}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q00977}. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q00977}.
Interaction partners:
- Gap junction protein
- Gap junction beta-1 protein
- Gap junction alpha-5 protein
- Gap junction alpha-1 protein
- Homeobox protein NANOG
- Gap junction gamma-1 protein
- Gap junction alpha-4 protein
- Gap junction alpha-8 protein
- Gap junction protein
- Gap junction alpha-3 protein
Sequence:
MDWGTLQSILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIMVSTPALLVAMHVAYRRHEKKRKFMKGEIKNEFKDIEEIKTQKVRIEGSLWWTYTTSIFFRVIFEAVFMYVFYIMYNGFFMQRLVKCNAWPCPNTVDCFISRPTEKTVFTVFMISVSGICILLNITELCYLFIRYCSGKSKRPV
Protein: Spectrin beta chain (E0AHA7)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- AO66 ankyrin
- Spectrin alpha chain
- Uncharacterized protein C50C3.2
- RNA-splicing ligase RtcB homolog
- Uncharacterized calcium-binding protein C07A9.5
Sequence:
MSSVDDEHHPSIEVDIPDVYESASDCEKTEDCTYLGSILKAKKSLRKTKKVASPGIYPGSAGALSSLSNGLADENRSPTSAEVSDSVCGQKSINSVDLRFRGLRDERELVQKKTFTKWVNSHLVRVSCKVQDLYMDMRDGKMLLRLLAVLSGERLPKPTPGKMRIHCLENVEKGLQFLRNQHVHLENLGSHDIVDGNSRLTLGLIWTIILRFQIQDITFEDADNHETRSAKEALLLWCQMKTAGYPNVNVKNFSTSWRDGLAFNALIHKHRPDLVDYDNLQKSNALYNLQSAFDTAENQLGLAKFLDAEDVNVDQPDEKSIITYVVTYYHYFNKLKQDNIQGKRIGKVINELMENDKMINRYETLSSDLLEWINAKIQLLNERHFENNLEGVQRQLTEFNDYRTQEKPPKFDEKGELEVLLFTLQSAMRANNQRPFVPREGKLIADINRAWQSLEKAEHERELVLKEELIRQEKLEQLAARFNRKAEMRETWLTENQRLVSQDNFGNDLSSVEAATKKHEAIETDIFAYEERVQAVVAVAGELEAENYHDQAKINERKENVLQLWNYLFQLLLARRVRLELSMAIQKIFHDMLLTLDLMDDIKSRLLSEDLGAHLMDVEDLLQKHALLESDINIIGERVNNSIAQAQRFRNPDGPDGSGYKPVEPGTIDERSDVLQKRYKELLDLAAERKRRLEDNKRLCQFWWDVAELEHGIKEQEQVLSSTDTGRDIVTVSHLLAKHKNAENNLRDLEKYLDRLDVSGKELQDESIPGSDNIPPRLAEIRDYINKLKELSASRKERLAGGVEYYQFFTDADDVDRYLYDTLRVMSSEDVGKDEGTVQLLLKKHDDVHDELQNFDQHIKVLHAKAESLPQEAREHPDIRQRLDTTLKQKAELENLSQLRKQRLIDALSLYKLYSDADSVESWIDEKGKLLATLVPGRDIEEVEIMKHRFDTLEQDMKNQEAKVTNVNDLARQLLNVEHPNSDDILHRQNKLNARWAQLRDMVDQKRNELERAHRLETFRIDCQETVTWIEDKTRVLEDSDALTNDLSGVMKLQRRLSMMERDLGAIQAKLDSLHKEADDIERERPQEAQAIREDIKRIHQVWDILNKKVREHEAKLDEAGDLQRFLRDLDHFQAWLTATQRQVASEEEPQSLAEAEQLLNQHAAIREEIDGYAEDYKKMRAMGDRVTQDQTDPQYMFLRQRLAGLQEGWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEVMLSQQENYLAKDDIPQSLEQAENQLKRHQDFITTMDANDEKIRAVGMFGDQLCQDGHYAADKIHKKARNIDERRGANREKAQEVLKKLKDALSLQQFLSDCDELREWIEEKMIRAQDETYRDAKTITSKFVRHQAFQSELAANKERLDQLKHAAINLGDDKPEYHGTIDPQIEELATQWDELEKTTEEKGQKLFDANRQQLYVQSIADMKEWATQLENEMTREDQPGDLTTVNVAMQKQHLIETEMIKKAQHIDQLMEMEPQLEELHPDELENIKAHRLAVQEQLQRLQAPLDDRRKALERKKAAFQFGRDVDDEKLWISERLVLAKAQNLGESLPDCHRLQKNLQLLSNEIDNHEPWINQICNNGQELIDEGHANGPAFEKKIQELRSAWQELKEAVKDRKGDLGESEKAHQFLYDCGEAEAWMSEQELYMMQDERGKDEFSTKNQIKKHERLQSDIDKFADTIRALATKAHKFVEEKSPLTEQIQVRQAQIEKLYAGLQDLSKERRKRLEETLELYALHREIDDLLQWIADKEVVAGSQENGQDYEHVQMLQERFQQFARDTENIGSERVANANDGCDTLIGHGHTDAPTIALWKDSLNEAWENLLELMDTRAQILEASRLLHKFYHDCRDCLSRIMEKTHAMPDDLGRDSSSVGALSRKHQNYLKDIAAIGEQVAQIERDAAELRDGYAGDKALDIGSRESEVVKAWRHLRGLCDARTSRLMDTSDLFKFMNMVRDLLLWMDEVKREMNSQERPKDVSGVELLMNNHQSLKAEIDAREENFNACISLGRDLLNRKHYASSEIEKKLIKLTTERAEMMRRWEDRWEYLQLILEVYQFARDAAVAESWLFAQEPYLISKEYGRNLEETIKLIKKHEAFEKSAFAQEERFLALEKLTTFELKETQHREEETAKRRGPAHIGSPSRSTPAAETSFGAQDDGAKQGEAFEGTLIRKHTYESLDRKAANRSWEKLYAVLRQNELSFYKDPKHRDESVHGEPPMALPGCSVNVASDYQKKKNVLSLRLPIGAEYLFQCGSEEDMQRWLTELQVATGQAQLEEASRSQTLPAEGSATKKKGGFFSRGKK
Protein: Zinc-finger homeodomain protein 4 (AtZHD4) (Homeobox protein 31) (AtHB-31) (Protein FLORAL TRANSITION AT THE MERISTEM 2) (Q9M9S0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor. Probably involved in the regulation of floral induction.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Probable carboxylesterase 11
- PX domain-containing protein EREX
- At2g35290
Sequence:
MEIASQEDHDMPIPLNTTFGGGGSHGHMIHHHDHHAANSAPPTHNNNNTTQPPPMPLHGNGHGNNYDHHHHQDPHHVGYNAIIKKPMIKYKECLKNHAAAMGGNATDGCGEFMPSGEDGSIEALTCSACNCHRNFHRKEVEGELAATAMSPYHQHPPHRKLMLNHQKIRSAMPHQMIMPIGVSNYRYMHNNSESEDFMEEDGVTTASRSLPNLPYNQKKRFRTKFTPEQKEKMLSFAEKVGWKIQRQEDCVVQRFCEEIGVKRRVLKVWMHNNKIHFSKKNNINLEDNDNEKINNLNNVDLSGNNDMTKIVP
Protein: Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)] (Q9GZP0)
Organism: Homo sapiens (Human)
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
Interaction partners:
- Platelet-derived growth factor receptor beta
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- Platelet-derived growth factor C
- Pro-epidermal growth factor
- Epidermal growth factor receptor
- Insulin-like growth factor 1
- Protransforming growth factor alpha
- Insulin
Sequence:
MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR
Protein: Nuclear receptor coactivator 6, isoform D (M9NES4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPLKQQLEPSLVRILVSLPWDAAQRLRQLANDGNPELRALNIQSVQFEGDSVINLKVGGQDIKITKDNVNETLEAAGSLSGNKSGLLATGFDGPSTSKAASAFMQQQQQRILQQPQNDAISLQQRRAAAAGLGLQKMPLHTTQQQQQQQQQQQVAVTPAVFKSPNTVCPMEGKVPLLLPSPSATRDFPFESMRQARVLQGREAGGLGPPLPPPPPPNVTLKVLKTQQQQAPQNGELTPTTPTSAAPTPPGSKSQFIQPPPPPYPGLGAATASSVSSPIAIAGVSAKPAIVTAPSQLNHPLGHPPLPTATSTGSNNIAISSPLLVNLLQNDGNGMSNPNQLKSPQQQQQQSPLIGMSPSGAQMMNSPMRSSGPATPSDFLMGDVLSPVVPSSPTTPQAAAPPCPPPVVMRNLQQQQQQHQQAMLSPSGNANHLYTQQQQQGPQQQQPQQQQQGPPHRFQQQHQQMSPQAVALRQQQLQRQQQMRFMQPQQQLQGQQQPQQQFQPAPDCFNNMGMGPMQQQQIRHQLRPGGLPLAPPPPHPQQQQQQRLMGLSMPQASPQQQFMSGASPLGPALSPASSHHSMHSPLMSNHQAQQQQQPQMVSPAATPGPTAPSEMAGQLMPANQHVPAAPPPDYNQAAVNSRWPLAGINKPMDSATKSSFQEFTRYQMQYNLQQQQQQVSLPGQPQQQQQQPQQQQLPPPALPTQQQQQQQSHVQQPQVAGQTQGQVDSLISLSVLDTLTTNDLDALLPTLNCDLDSTLSLEDKNELESLLQDAKDLDLDLIEDNLSAVDMRDALNTLQEAPLEQQQQQQQQQAAMQPQQQTAQMMQMPYQQQPQQQQQMQQQLMMQQQQRQQQLPQMQQRQQQHLQRQLQLQQQQQQQQQQQLQIVQRQQQQQQSQLQVQHPQQPQRPPQKQFIINPHTGDMEPMASDDSETEAEEETAQPQFRNSHSGLGSFNFNPANDMLLPTNLFSEEDSNSAQQHPMGISSDQERSRDSLASNKSATSRARKTPVSKANHSNFSAGDNSPRSSNSSPLIGLNSPQSVNANAGGAPSKKAKPNLLRGKLQQGVKERKAKDPTAAPKQKRERAKGNVKTKAAEEKIKLRLKLEKVETTPAAGAGYEGQIIINQQQQQTIVVNNHMQQLPMQTQLLALPTQQQQQQQQQQQQQQQQMQQPQMQISQQQHQQQQQTSQLQQQPAQLQQQQPQQQQQQPIQQQQQHHPVYSNFQQQQQQQQQQQQNVPGPNEPRVPPLQIRLRGKNHVVVKNTRKDRKKGQNQEASIDERQLKRSYSDQPPQQLLMDPAESKQAKLTPPPHVNGLPILIQKTTATVASPQLPQQLQGGVATTTKTTTIVAGKNGLTISAIVEAHKAQAQAQAQSLNDPQLIVGSTNTGTTPTSTTLQQQQLSKIATSLPSSITLSAINSNNNNNNVNSGNNNNRLLTMKNPIKTAATITPIVGGKPMTKNHKPPPYITAVQQLQLQKQQQQQQQQQQQQQQQQQQQQQRQLAAAVTMLPSATTLKRVEITKVTPQVTAEQAPSINPSPVVVAAAATATLTTSSTPTTQTTQLICDRKLPVAMPPMTTVNNVVVATVNSSSAALSTLSSVSTASSASIITTSTSTSSPAALPSTLRNSPASNGSGTPGHGNNGGGEDSGIESMDALSEKSPHQLSSSSPIQVSKAAVTMVQQQQQQTNAIVTITTSAAVIAPVIAPTSTQAGTTPTVAPSLQQQQKQQADDEIEKALAKMEGDFPDDLEDIVSSMIKETSECASAAGGGFLNSLESSLPAATVATVVSTASTNTSSIGSIKLNGEHHILEHDDLIKKLTESKPPAIKVKLEEMPPLLTIKKEPVIKPMASGLKVEAKVEVKLEPKVEPKSEEKLQEKPPSESSSASLQPISIEIPAQVDGETPRIRTRASSRLESPLDAQKASPDPTTVTGVSTTAATAANASTTVKSLSRASSTASPRVVTPTPNHNNNNNKRRRQESECGSSNDGADLGENSIKRPRISSGTTSNNNATETAAEHNAGAGLPKKVEIESSDSDEPLIEVAGKVRNSKQAQVEAADAAAVGVEKHVTRRNAQQLQPPQNKTAGNHAPSSTPALGTPRSGKAQAPVGATSAANNNHNSSTANNASVVPSSVTTTTMPGGAVVTTSQVNSGTSVVHATRGATAAAASTTNNNSASSPTDEKIGTRRSVRASAAANKIIYSRSNAAAAAAAAAAAAEPKGTTGKAGAAVGANNAGNVESVAEARRKTRSAVIGESMLTEGRRRRTSRDYK