wanglab/gogpt-training-data huggingface dataset:
Protein: S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] (Q8T1E3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: S-adenosylmethionine decarboxylase is essential for the biosynthesis of spermine and spermidine. The alpha subunit contains the active site (By similarity).
Interaction partners:
- Spermidine synthase
- S-adenosylmethionine synthase
- Methionine adenosyltransferase regulatory beta subunit
- Probable ornithine decarboxylase
- Enolase-phosphatase E1
- Arginase/agmatinase/formiminoglutamase family protein
- Bifunctional purine biosynthetic protein purD
- Bifunctional protein argC
- Probable deoxyhypusine synthase
Sequence:
MPILSTEIFNEADAGFVYQSNSNDYSDGFEGPEKKLDIRFGPISKGSVKSIAGSPSKVGLRTIDKEKWQTVLDSARCTIISQTSNDHMDSYVLSESSLFVYPRRAMIKTCGTTTLLHLIAKMVQVGKECGLEVEMVVFSRKNLNQPSKQVFPHCSFSDEVNFLNKIFDGQAYVMGDVNKDHWNLYIADFRKNPTLQRTEQTFEVMMHDLDETVMKQFFKREGVSAWDTTVNSGIADLLPGSMIDDFQFDPCGYSMNGLLNEFYWTIHITPESHCSYVSFDTNVALADYNQLLAKVLNVFKPGRFTAALYAEDGAPCGDPYTAFDVNVPSYAIQNKTVHGFDGGYDVVVSNYQQLDKKVNFSNDDLIQSIESTNIDLIQV
Protein: Rab family GTPase (Q5AI00)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046278}; Lipid-anchor {ECO:0000256|ARBA:ARBA00046278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00046278}.
Interaction partners:
- Rab GDP dissociation inhibitor
- Uso1p
- Oxidant-induced cell-cycle arrest protein 5
- Arf family guanine nucleotide exchange factor
- Trafficking protein particle complex subunit BET3
- NADH-ubiquinone oxidoreductase chain 4
- Trs33p
- TRAPP subunit
- Ras-related protein SEC4
- Trafficking protein particle complex subunit
Sequence:
MNNEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTPDYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTDQESFNNVKQWLQEIDRYATGGVMKLLVGNKADLSDKKIVEYTAAKEFADALDIPFLETSALSSTNVEQAFYTMARQIKAQMTNNANAGNAANAKGKSNVNLRGESLTSNQSNSCC
Protein: Protein halfway (Protein singed wings) (Q9W568)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes.
Interaction partners:
- trypsin
- Vacuolar protein sorting-associated protein 18 homolog
Sequence:
MLAYTHGTWLLLLLLLVAGACARPEIAHTPDPAALGEESTPHAHAHPQARHHHHAHPHAPLKEDEQGTAIPAPILTTDNVGIGETTTASSLAETQSMSDPGSVTDTTSTSTSHSTSTTSTTSPAPLPPAAPEQPEYLKHCFYAEEQLCGHTFDGRAETSEGQGSTVAQSEAQNRGGQGNSQCQCREHPTRPNSWYCCNISQLTMISSCSNISKWTNLHVRNMTVEDMDLSNPIFRSLQSLAVTDGNITRLVNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNNLSLVPHRNQNKNITLDISGNMRMLCTPLNEIIYTESINFLNPKHSYCQYNATHTWFQSTDKVSVEQLENRKRCVTNCPVIPNYGSCNCTLENIMIIQDNQSKPQCHVDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTYHNINRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNALMDSGLGRRIYLAGNKLQCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMPQRVIELQEAKLCQSPPDWTDYIYYLIAAEVLLLLALITKVSYDYWVFKTAGYLPWPASKMPKLPCDWLCES
Protein: Outer envelope protein 64, chloroplastic (Translocon at the outer membrane of chloroplasts 64-III) (Q9LVH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chaperone receptor mediating Hsp90-dependent protein targeting to chloroplasts. Bi-functional preprotein receptor acting on both sides of the membrane. Not essential for an efficient import of pre-proteins into plastids.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glutamyl-tRNA
- Aspartate--tRNA ligase, chloroplastic/mitochondrial
- Heat shock protein 90-2
- Translocase of chloroplast 33, chloroplastic
- Ankyrin repeat domain-containing protein 2A
- Glutamate--tRNA ligase, chloroplastic/mitochondrial
- 22 kDa peroxisomal membrane protein
- Glutamate--tRNA ligase, cytoplasmic
- Glutamine--tRNA ligase, cytoplasmic
- Large ribosomal subunit protein eL39y
Sequence:
MASQAANLWVLLGLGLAGILMLTKKLKKTVREDFGAFIDKLMLLPPPQPAPPKAPHPLTGLTFAVSDVFDITGYVTGFGHPDWVRTHEAASSTSPVVSTLVEGGATCVGKTVVDEFAFSISGENKHYDSPTNPAAPTRIPGGACSGAAVAVATNAVDFALGIDTVGGVRVPAGYCGVLGFKSSYGAISNTGIIPVSSSLDSVGWFARDPNTLRRVGHVLLQLPFATQRNPRQIILADDCFQLLKIPVDRITQVVTKSAEKLFGRQLLKHQNLETYFETKVPSLKEFARTKAIANTKVSTSRLLANVMQLLQRHEFLQNHGDWINTVKPAIDPVILSQVCENPELTNEETENLNAIRNETRVAIGSLLKDDGILVIPTLPAVPPKLGSKEITSEDYQNRASSLLSIASISGCCQVTVPLGHHEKCPISVSFIGRHGGDRFLLDTVQTMYPSLQEYSSIVTDPKSSKKAITKEESAEIAKEKGNQAFKEKLWQKAIGLYSEAIKLSDNNATYYSNRAAAYLELGGFLQAEEDCTKAITLDKKNVKAYLRRGTAREMLGDCKGAIEDFRYALVLEPNNKRASLSAERLRKFQ
Protein: Sporulation-specific protein 4 (P09937)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not essential for sporulation. Might be a component of the cell wall.
Interaction partners:
Sequence:
MPSNLNIVKVTKPQEENKNFLHKNTNEPNEMEQSQTQEAVTENFTENSNLSANEHAARRGRLNLKTVDHIETYPIVQETEEIAKKIALTRIILAQTKPRIDKVVVSRPVQAVAPVVNFFDKMANSTLSTVERVVPSLKTKTYKRLGEEIALPYTLSKKYGKQLRDTTARNGDNYVYQPVHGRLMKFRKYYNEKFIDTKGKPLIRGQLDPVLLPVNNTFEKVTVKYLPKGKKVPNDSFSCEFNRGLALEYNFMTRAVSAVSHQVVGIAKLPIAYGYHTNSVYNKNLDKQADLKMKNVLRGTWDTITDLEREIWASVTDRSLFRFFGNKSEGGDLPHLVQ
Protein: Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1) (Q7Z2H8)
Organism: Homo sapiens (Human)
Function: Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA. May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12527723, ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:19549785}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12527723}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000255}. Note=In neurons, colocalizes with the exocyst complex in the axonal processes. {ECO:0000250|UniProtKB:Q924A5}.
Interaction partners:
- Neutral amino acid uniporter 4
- Proton-coupled amino acid transporter 2
- Ras-related GTP-binding protein C
- Neutral amino acid transporter 9
Sequence:
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
Protein: T14N5.3 protein (Transmembrane protein, putative (DUF506)) (O80651)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Calmodulin-like protein 9
- Protein CONSERVED IN THE GREEN LINEAGE AND DIATOMS 27
- Uncharacterized protein
- Calmodulin-like protein 8
Sequence:
MGSLGEEDLEKLVLDYIESPITVSQHIESSTTALITLKEILRAKGEKEKEMEEKIWSFINGGRLSYEGDDEKRDVMNKIVSKLRSEGYDASLSKTSWDSSFDHREGCRVFRCSRKYEYIDVMVKGDSNRDGVSKLKRVIIDLDFKTQFELARQTEAYKDMTEMLPLVFVATEGRLRRVVSLVCGEMKKSMKKEGMSRPPWRTTRYMQSKWLPENRRRVSGCKKGSWSWSVFDDGSEGRGEARTWTVSGSGPKTKCCFPIF
Protein: Lysozyme-like protein 4 (Lysozyme-4) (D4ABW7)
Organism: Rattus norvegicus (Rat)
Function: May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9D925}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D925}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:22110709}. Note=Found in the principal piece of sperm tail. {ECO:0000250|UniProtKB:Q9D925, ECO:0000269|PubMed:22110709}.
Interaction partners:
Sequence:
MQLYLVLLLISYLLTPIGASILGRCVVAKKLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYENSRDGSTGFGLFQIRDNEWCDHGKNLCSVSCTALLNPNLKDTIECAKKIVKGKQGMGAWPVWSRNCQLSDILDRWLDGCEL
Protein: Fructose-bisphosphate aldolase (EC 4.1.2.13) (Q27744)
Organism: Plasmodium falciparum (isolate K1 / Thailand)
Function: Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (By similarity). Stimulates actin polymerisation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P14223}. Membrane {ECO:0000250|UniProtKB:P14223}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Host cell membrane {ECO:0000269|PubMed:2204832}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
Sequence:
MNAPKKLPADVAEELATTAQKLVQAGKGILAADESTQTIKKRFDNIKLENTIENRASYRDLLFGTKGLGKFISGAILFEETLFQKNEAGVPMVNLLHNENIIPGIKVDKGLVNIPCTDEEKSTQGLDGLAERCKEYYKAGARFAKWRTVLVIDTAKGKPTDLSNHETAWGLARYASICQQNRLVPIVEPEILADGPHSIEVCAVVTQKVLSCVFKALQENGVLLEGALLKPNMVTAGYECTAKTTTQDVGFLTVRTLRRTVPPALPGVVFLSGGQSEEEASVNLNSINALGPHPWALTFSYGRALQASVLNTWQGKKENVAKAREVLLQRAEANSLATYGKYKGGAGGENAGASLYEKKYVY
Protein: ATP-dependent DNA helicase SRS2 (EC 5.6.2.4) (DNA 3'-5' helicase SRS2) (P12954)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. The polarity of the helicase activity was determined to be 3' to 5'.
Subcellular location: Nucleus.
Interaction partners:
- DNA repair protein RAD51
- ATP-dependent helicase SGS1
- Proliferating cell nuclear antigen
- Postreplication repair E3 ubiquitin-protein ligase RAD18
- DNA repair protein RAD5
- DNA repair and recombination protein RAD52
- Ubiquitin-like protein SMT3
- Ubiquitin-conjugating enzyme E2 2
- ATP-dependent DNA helicase MPH1
- DNA repair protein RAD55
Sequence:
MSSNNDLWLHLVSQLNTQQRAAALFDYTRGLQVIAGPGTGKTKVLTSRVAYLILHHHIHPRDIIVTTFTNKAANEMKERLQEMLRGAGVNISELLIGTFHSICLKILYRFGHLVDLQKDWRIIDEKEIDVILDDMIEKVPDQIRDYASSITRKVNLCMPSKNGDEWTIHPKLIKKQISKLKSNAILPEEYILDSNHDAALGYFYQIYQSELSKKNTLDFDDLLMYTFRLLTRVRVLSNIKHVLVDEFQDTNGIQLDLMFLFAKGNHHLSRGMTIVGDPDQSIYAFRNALAHNFLEMGRKCPIEYSTIILVENYRSSQKILNTSEILITQQNKGRQNRAPLRAQFDLDFPPVYMNFPAYFLEAPSLVRELLYLKALPNLFTFNDFAILVRQRRQIKRIESALIEHRIPYKIIRGHSFWDSKETRAMLNLLKLIFSPNDKHAILASLLYPARGLGPATGEKIKNALDTLATDVSCFQILKDISSKKIMLDIPTKGRSVIADFISMIENCQLLLQSTLLGGLSDLFDKLYELSGLKYEYLYKDGKKKNDQLEKSEPNLLNARHKNIELLKNYFLALLSKSESSDKEKNEAIKAATDEAEPIENKVITPKEYLRNFFNSLSLHSDAAEEEESESNKDAKIKREKNGFVTISTIHGAKGLEWPVVFIPGCEEGIIPCVFNDDKKDESEEDEEEDQENSKKDASPKKTRVLSVEDSIDEERRMFFVAQTRAKYLLYLSNTVTVEDVDRPRIASRFLTTDLIKAMSDSQKLFESTNSIKKLYRILNKKPPAEDDKLFSLDQLRKDYNQFIENRRERMIWQGIQMNDVYGIQLSRNKLLGSVSDFTSAADQLRLETQNSIFPQKKLIEKSRPSKINGNYAPKSRVKSPEKRYAPETTSFHSPTKKKVYAPQYVSTTNVPSRQEFHSSTGKNIPFLRREDRSITDISPRSSTRSLKGASPNKTSHMSDDLMRPSPTRKDKVTRNIHFATAGTFRIETQSNVDELHPPEYSNKSGQSLTSSEFSGFSSACSNSDQPTNLIEDINNELDLSDEELLNDISIERRRELLGSKKTKKIKPKTRNRKSKRGDKVKVEEVIDLKSEFEEDDSRNTTAAELLHNPDDTTVDNRPIISNAKFLADAAMKKTQKFSKKVKNEPASSQMDIFSQLSRAKKKSKLNNGEIIVID
Protein: Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1 receptor) (GkAT1) (O35210)
Organism: Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus)
Function: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30556}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30556}.
Interaction partners:
Sequence:
MALNSSADDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPVWAVYTAMEYRWPFGNHLCKIASAGISFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVVIWLLAGLASLPAVIHRNVYFIENTNSTVCAFHYESQNSTLPVGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWIPHQIFTFLDVLIQLGVIRDCKIADVVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMNSSAKKPASCFEVE
Protein: ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 2) (ATP synthase proteolipid P2) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C2) (ATPase protein 9) (ATPase subunit c) (Q06055)
Organism: Homo sapiens (Human)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit d, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
Sequence:
MFACSKFVSTPSLVKSTSQLLSRPLSAVVLKRPEILTDESLSSLAVSCPLTSLVSSRSFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM
Protein: Large ribosomal subunit protein eL18y (60S ribosomal protein L18-2) (P42791)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- At1g43860
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein eL32z
Sequence:
MGIDLIAGGKSKKTKRTAPKSDDVYLKLTVKLYRFLVRRTNSKFNGVILKRLFMSKVNKAPLSLSRLVEFMTGKEDKIAVLVGTITDDLRVHEIPAMKVTALRFTERARARIEKAGGECLTFDQLALRAPLGQNTVLLRGPKNSREAVKHFGPAPGVPHSHSKPYVRAKGRKFEKARGKRKSRGFKV
Protein: MICOS complex subunit MIC10 (AtMic10) (Q8LAJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q5TGZ0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
METTKSNSSESDVNAKWDACLDLTARRFVYSSLGGAFAGLLFFRSPVTRWASIAFGAGIGIGSAYTDCSRVFDASSSTSATLLAAPKSTETSVSQAAEE
Protein: One cut domain family member 2 (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) (Q6XBJ3)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPVGGGSGGGGGGGGGGGGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGSDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHHHQRLSGNVSGSFTLMRDERGLPSMNNLYSPYKEMPSMSQSLSPLAATPLGNGLGGLHNAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLGTGGSSSTSSTCTKA
Protein: Complement C3 (Q90633)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGLLLLPLLLGVLLLHAVPTPAQMVTMVTPAVLRLDTDEKVVLEAPGLSAPTEANILVQDFPQKRKVLFQVRKQLNPAEGMMAIATVKVPVKLLPPVVGKHFVSVVARVGQVTLEKVLLVSLQSGHIFLQTDKPIYTPGSTVLSRLFALSHFMQPLLKTVIVEVKTPDNVIIKQVPVSSPMRNGIFSINHNLPEVVSLGTWTITAKFEDSQDQVFSTQFEVKEYVLPSFEVTLDPQEKFLYIDPAEDFRVTITARYLYGKNLQGTAFVLFGVVVDDEKKTIPQSLQRVKVTDGDGQAVLPMAMLRQPFANLQELVGHSLYVTVTVLTESGSDMVEAQRSGIRIVTSPYTIHFTHTPKYFKPGMPFDPTVYVTNPDNSPAAAGIPVKADNFQGLVSTQRDGTAKLVLNMPANKNSVPITVRTDQKDLPPERQASRQIVAEAYQSQGNSGNYLHLAVGASQVQPGDNLPINFHLKSNRDDVRKSVSYFTYLILSKGHIVHVGRQPREGDQSLVTMSLPVTANLIPSFRIVAYYHVKPGEIIADSVWVDVKDTCMGSLVVRGASEADNRVHEPRTPMRLHIEGDHKAHVGLVAVDKAVYVLNKNKLTQSKVWDTVENSDIGCTPGSGRNQVGVFADAGLSLTSNVNINTEQRSEVQCAKPAKRKRRSVRLIKHKGTKMAEYSDKNLRKCCEDGIRKNLMGYSCEKRATYVLDAKSCTEAFLSCCLYIKGIRDEERELQYELARSEVDDAFLSDEDITSRSLFPESWLWQVEELTEPPNEQGISMKTLPIYLKDSITTWEVLAVSISENKGLCVADPYEITVMKEFFIDLRLPYSAVRNEQVEVRAILYNYWTNKIKVRVELMYNPALCSASTTKTRYQQIFQLEPQSSDAVPFVIVPLELGQHDVEVKAAVWNSFVSDGVKKKLRVVPEGMRLEKTVKIVELDPKTLGNNGVQEVKVKAANLSDIVPNTESETKVSIQGNPVSILVEKATDGTKLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDSTMQWETFGINRRTEAIELIKKGYTQQLAYRKEDGSFAAFTTRPSSTWLTAYVAKVFAMAINMVDIKPEVVCGAIKWLILEKQQPDGLFQEDAPVIHKEMVGGYHGAEPSVSLTAFVLSALQESQKICKNYVKSLDGSIAKASDYLSRKYQSLTRPYTVALTSYALALTGKLNSEKVLMKFSKDGTHWAERNAHTYNIEGTSYALVALLQMEKAELTGPVVRWLAQQNYFGGGYGSTQATILVFQALAQYHVALPRHVELNLDVSVLLPRRANAITYRIENNNALVARSAETKLNEDFTVKAEGTGKGTMTVVTVYKAKVPEKENKCDNFDLRVSVEDVKAGREVEGVIRSVKITICTRFLDTVDATMSILDISMLTAFSPDVQDLKSLSEGVERYISKFEIDHALSNRSNLIIYLDKVSHQVEECIAFRAHQHFQVGLIQPASVIVYSYYKIDDRCTRFYHPDKAGGQLRKICHGEVCCAEENCFIRVKKDNPITVNERIDLACKPGVDYVYKVKVVATEETPSHDNYIMSILTVIKMGTDENPGGSNRTFVSHKQCRDALSLQKGQDYLVWGLASDLWVTGSRFSYLISKDTWLEAWPLEESCQDADLQPLCQDFTEFSDNLVLFGCPT
Protein: Protein Hook homolog 2 (h-hook2) (hHK2) (Q96ED9)
Organism: Homo sapiens (Human)
Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17140400}. Cytoplasm {ECO:0000269|PubMed:32073997}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TMK6}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:32073997}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q7TMK6, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:32073997}.
Interaction partners:
- AKT-interacting protein
- FHF complex subunit HOOK-interacting protein 1B
- Protein Hook homolog 1
- Protein Hook homolog 3
- Zinc finger CCCH domain-containing protein 14
Sequence:
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
Protein: Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) (Q9WTV8)
Organism: Microtus montanus (Montane vole)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSFPRGSYDPAASNSSPRWPLSAEDANSSREAAGHQKGSDPSGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWVLSFLLSTPQYFIFSMIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVVPVVILGTCYGFICYHIWRNVRGKTASRQSKGSGEDVAPFHKGLLVTPCVSSVKTISRAKIRTVKMTFVIVTAYILCWAPFFIVQMWSVWDDNFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQRMVQKFTKDDSDNMSRRQTSYSNNRSPTNSTGTWKDSPKSSRSIRFIPVST
Protein: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) (Q8TCU6)
Organism: Homo sapiens (Human)
Function: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Subcellular location: Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Interaction partners:
- Ras-related C3 botulinum toxin substrate 1
- Ras-related C3 botulinum toxin substrate 3
- Guanine nucleotide-binding protein G
- Cell division control protein 42 homolog
- Guanine nucleotide-binding protein G
- Ras-related C3 botulinum toxin substrate 2
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Sequence:
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL