wanglab/gogpt-training-data huggingface dataset:
Protein: Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) (dCPSF 160) (Q9V726)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Symplekin
- Probable cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor 73
- Cleavage stimulation factor 64 kD subunit
- LD24014p
- Cleavage and polyadenylation specificity factor subunit 4
- Factor interacting with poly
- Pre-mRNA cleavage complex 2 protein Pcf11
- polynucleotide adenylyltransferase
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Sequence:
MFSMCKQTHSATAVEFSIACRFFNNLDENLVVAGANVLKVYRIAPNVEASQRQKLNPSEMRLAPKMRLECLATYTLYGNVMSLQCVSLAGAMRDALLISFKDAKLSVLQHDPDTFALKTLSLHYFEEDDIRGGWTGRYFVPTVRVDPDSRCAVMLVYGKRLVVLPFRKDNSLDEIELADVKPIKKAPTAMVSRTPIMASYLIALRDLDEKIDNVLDIQFLHGYYEPTLLILYEPVRTCPGRIKVRSDTCVLVAISLNIQQRVHPIIWTVNSLPFDCLQVYPIQKPIGGCLVMTVNAVIYLNQSVPPYGVSLNSSADNSTAFPLKPQDGVRISLDCANFAFIDVDKLVISLRTGDLYVLTLCVDSMRTVRNFHFHKAAASVLTSCICVLHSEYIFLGSRLGNSLLLHFTEEDQSTVITLDEVEQQSEQQQRNLQDEDQNLEEIFDVDQLEMAPTQAKSRRIEDEELEVYGSGAKASVLQLRKFIFEVCDSLMNVAPINYMCAGERVEFEEDGVTLRPHAESLQDLKIELVAATGHSKNGALSVFVNCINPQIITSFELDGCLDVWTVFDDATKKSSRNDQHDFMLLSQRNSTLVLQTGQEINEIENTGFTVNQPTIFVGNLGQQRFIVQVTTRHVRLLQGTRLIQNVPIDVGSPVVQVSIADPYVCLRVLNGQVITLALRETRGTPRLAINKHTISSSPAVVAISAYKDLSGLFTVKGDDINLTGSSNSAFGHSFGGYMKAEPNMKVEDEEDLLYGDAGSAFKMNSMADLAKQSKQKNSDWWRRLLVQAKPSYWLVVARQSGTLEIYSMPDMKLVYLVNDVGNGSMVLTDAMEFVPISLTTQENSKAGIVQACMPQHANSPLPLELSVIGLGLNGERPLLLVRTRVELLIYQVFRYPKGHLKIRFRKMDQLNLLDQQPTHIDLDENDEQEEIESYQMQPKYVQKLRPFANVGGLSGVMVCGVNPCFVFLTFRGELRIHRLLGNGDVRSFAAFNNVNIPNGFLYFDTTYELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRENRVYCLITQTEEPMTKYYRFNGEDKELSEESRGERFIYPIGSQFEMVLISPETWEIVPDASITFEPWEHVTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGKPMTKFKIKEIFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDGDLIGVAFIDTNIYVHQIITVKSLIFIADVYKSISLLRFQEEYRTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLGGQKLLRKADYHLGQVVNTMFRVQCHQKGLHQRQPFLYENKHFVVYGTLDGALGYCLPLPEKVYRRFLMLQNVLLSYQEHLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKIGTRTEEILGDLLEIERLASVF
Protein: Type II methyltransferase M1.BsuMI (M1.BsuMI) (EC 2.1.1.37) (BsuMI modification methylase subunit YdiO) (Cytosine-specific methyltransferase M1.BsuMI) (O34939)
Organism: Bacillus subtilis (strain 168)
Function: A methylase, recognizes the double-stranded sequence 5'-YTCGAR-3', methylates C-3 on both strands, and protects the DNA from cleavage by the BsuMI endonuclease.
Interaction partners:
- Type II methyltransferase M2.BsuMI
- Putative type II methyltransferase M.BsuMIIP
- S-adenosylmethionine synthase
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Uncharacterized methyltransferase YrrT
- S-adenosylmethionine decarboxylase proenzyme
- Type II restriction enzyme BsuMI component YdiS
- Type II restriction enzyme BsuMI component YdjA
- Type II restriction enzyme BsuMI component YdiR
Sequence:
MTNFILNENKQLSLAIEDENIENFYIDGTDLVRKIIRRSGSGVTSRVPVLSTQDLENKNLHELYDESWLRMKNRPNTELTTESINIADLFSGCGGLSLGVWEACRALGINPRFSFACDLNEAALSVYEKNFSPDFSLNESIEKHINGELGAPLTVEEQRIKDKVKKIDFILAGPPCQGHSDLNNHTRRKDPRNALLMRVSRVIELFQPSSVLVENVPGIIHDKSGSFKEFKNHLKTQGYYFDEIVLNAEKLGVSQARRRYFIFASKTPVSSLNQINEFYSTNSRPISWAISDLVENVGDDIFNTASEHSLENKRRIEYLFENNLFELPNSERPDCHRLKPHSYKSVYGRMYWDRPAPTITRGFGSTGQGRFVHSLLKRTITPHEAARIQFFPDFFNFGDLRRRQYQDVIGNAVPSKLSYLLALHQLR
Protein: Zinc finger A20 and AN1 domain-containing stress-associated protein 7 (AtSAP7) (Q9SZ69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in environmental stress response.
Interaction partners:
- Zinc finger
- F21J9.19
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Desiccation-related protein At2g46140
Sequence:
MGSEENNSTSFPPTEPKLCDNGCGFFGSPSNMNLCSKCYRSLRAEEDQTAVAKAAVKNSLKLPSCSIIAPGQKHPLEIKPAHLETVVVTAEPSSVPVAAEQDEAEPSRPVRPNNRCFSCNKKVGVMGFKCKCGSTFCGSHRYPEKHECSFDFKEVGRDAIAKANPLVKADKVQRI
Protein: Catalytic/ hydrolase (mRNA, clone: RAFL21-86-C08) (Q682E0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Haloacid dehalogenase-like hydrolase domain-containing protein At4g39970
- Haloacid dehalogenase-like hydrolase domain-containing protein At2g33255
- CBBY-like protein
- Multiple inositol polyphosphate phosphatase 1
- Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp
- 
- 
- WD repeat-containing protein WDS homolog
Sequence:
MAVTLRLTNSLAFSSHPLTSSVLFRGSKSIGTITKIASTIRTVKMAAFAGSDSETTSSTSRVIDSHLHIWASPQEAETYPYFPGQEPTLTGDVNFLLKNMEEARVDGALIVQPINHKFDHSLVTSVLKRYPSKFVGCCLANPAEDGSGITHLENLVLESNYRAVRFNPYLWPSGQKMTNAVGKALFSKAGELCVPVGFMCMKGLDLHIAEIEELCTEFPKTTVLLDHAGFCKVPESGEAKLAYSQLMKLSRFPQVYVKFSALFRISRTGFPYQDLSPLLSQLVSHFGANRVMWGSDFPFVVLECGYKEAKEAVTIIAKEASLSSSEMDWILGKTLMQLFPGQWVLP
Protein: Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2) (Q15822)
Organism: Homo sapiens (Human)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000303|PubMed:18723036}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000303|PubMed:18723036}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-4
- Neuronal acetylcholine receptor subunit alpha-7
- Neuronal acetylcholine receptor subunit beta-3
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit alpha-9
- Neuronal acetylcholine receptor subunit alpha-3
- Acetylcholine receptor subunit epsilon
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit delta
Sequence:
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Protein: Arrestin-related trafficking adapter 3 (Arrestin-like protein 2) (P47029)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Protein LDB19
- Ubiquitin ligase-binding protein BUL1
- Ubiquitin ligase-binding protein BUL2
- Protein ECM21
- Arrestin-related trafficking adapter 5
- Arrestin-related trafficking adapter 10
- Arrestin-related trafficking adapter 6
- pH-response regulator protein palF/RIM8
- Dicarboxylic amino acid permease
Sequence:
MPMDQSISSPLFPMEKDIDIPLDATPLAQSSSLQLFIHLAEPVVFLQGFDPQKTEYPSVVLRGCLVVRILKPTKLKSISLSFKGYSRTEWPEGIPPKRQEFVEIKDIVDHTWALYPPTEQKSKKKMDASAPNESNNAANNFLTKESGASLYRTLSDNETITSRKNSISGLSSLNLSPLGAPGNSSVNVKDRESRQRSRSSSVTSSNGPSRNLSPINLLKRATSPSVSHHNYKPTTTSIFSDLLNNTFTHNDAASHHGHHIPTSSNHLAMTSNNFTSGSGGEFFVFQPGDYIYAFEELIPQAYPESIKADFGFVEYFLFASIERPGAFKSNISARQVVNIVRTQAHNSVEESEPIIISRDWENQLYYDIVIASKDIILDAFLPITFKFAPLDKVTLHRIRIYVTETMEYYCREKKVHRMEPTKKFLLTEQKGPKLPNLPNDANLSKAKNMGNLLQDPKNGDLVNKEYEYQIFIPSRFNNHQQLHPDTSYENIKANHWIKICLRLSRVVDNKRKHYEISIDSPIHVLHRLCSHANTLLPSYDGHPASFPKETDSSISSILESSDDNINLYHNSNIFFPKEVLSSPVLSPNVQPLDILIPHLPSTSLTRNSRQFNRNSKSHPSDNTIFNSAKLKSNIYQPESLQRELASPQAIPLSPITSPMSNMEVPPPDFDFSSDFISDAASGTTTTEVSSSESSILPRDPPSYKDTVLHDNNQKRRPNSKHPTPPSLKASHPNKNSDKNSSETLNKKESMSKIEENKHKRETTPKKRENRDVKSLSTPQREESKDSTSTGNQSNEKNRKRVLSLSSSLHSSPNNSGFAHSALGNLSNESLRSLNRRESVQDNLPSTIRHDNPFFTDLNQVLIEDELKNHDKNELNRHSTNTSSTPASARSSFDYSGINISKDKLNMEPLLSKTETLTNKVNEDSFLRPNDSYVDLLEPSVDTTIDITAPYARNSSAWHPLQNDNDNNQFSPLLGSNENFLNAANAQNSAESDHNNDIFTQGSGLTESSKNSDSEERFISRLSSPEKVLINTLDNESGLQSINESTL
Protein: Chitin synthase regulatory factor 4 (Chs four homolog 3) (O94614)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in septum formation. Required for the proper localization of chs2 at the septum.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15449309}. Note=Localizes to the cell tips and septum during vegetative growth.
Interaction partners:
- 1,3-beta-glucan synthase component bgs1
- 1,3-beta-glucan synthase component bgs4
- 1,3-beta-glucan synthase component bgs2
- 1,3-beta-glucan synthase component bgs3
Sequence:
MDSASSMRNRSPLGVPEFSYSSQSVNNIRGIKSRNRSSIGHSITDPQVASRINAFYLSNVQSSIPFETDAIGPAYGIGDMIAPEMNDTQSLSASVTNMKKENFYSRPNVSSSSILLTIKRATSSQETKRDRPLPNIRNSAPSATRSHSTPCVAPGYLRTSNEAADVVFPHEEAHFSNHNPKPNNGSPLQKQVVADLPFPLPVSDEEQLDWIRANEDLVHSQDIDEALEWAEYVLRFTQSHLPYLQTYESENLHEINYLESMCENALYKIREFSELENAKAMYFDAYVYETGAFDVESDIQRAWDLYSSSANLGYTRSLYRLGVLLEDQGNLEEAVEYFEKGVSENDSACCWRLSLLILEGMLDGVGEYAHRHASGLELLERSADTADADVPSGLYSHALVNLHEHPGLVDLGSENIRVPIDEATALKSFAKAAFLGHSSAQLRMGAVYEFGKYGCPVVPRYSLFYYSAAAKRGETEADLAVAKWYLNGSDGIPVDEDLAFMHAERASMAGNANAQFLMGYLFDTRGNTEQATYWYNEAAKAGHSEAIERLALLENQIQEPEPENITSSQYPNQDVIKEIPVTASETSPPHAPAVSSTPVTSAPPVSQTKVTKVSVPKKTSKKFLIKHNKCIIS
Protein: Formin-like protein 3 (Q6ZPF4)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8IVF7}. Cell membrane {ECO:0000250|UniProtKB:Q8IVF7}; Lipid-anchor {ECO:0000255}. Note=Enriched in lamellipodia. {ECO:0000250|UniProtKB:Q8IVF7}.
Interaction partners:
- Rho-related GTP-binding protein RhoC
- Protein diaphanous homolog 3
- Cell division control protein 42 homolog
- Profilin-2
- Profilin-1
- Transforming protein RhoA
Sequence:
MGNLESTDGGPGEPPSVPLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPNVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGGEALARVGPTELTEGIPPSDLDLLAPAPPTEETLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQINGTVFSELDDEKILEDLDLDRFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
Protein: Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4ST-1) (C4ST1) (zC4ST-1) (Q7T3S3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Hexosyltransferase
- Sulfotransferase
- Sulfotransferase
- Xylosyltransferase I.
- Sulfotransferase
- Novel protein similar to vertebrate ring finger and WD repeat domain 2
Sequence:
MKQTILDLMRMSRICRMVLATCLGSFILVIFYFQSMFQPVMRRNPFAAEGCCRKGSRNALQELYNPTQAEFSAAAVLHQARRDQVAETCRAHSASSRKRRVLTPSDLKHLVVDEDHELIYCYVPKVACTNWKRVMMVLSGRGKYSNPMEIPSNEAHVPSNLKTLNQYSIPDINHRLKNYLKFLFVREPFERLVSAYRNKFTLRYNTSFHKRYGTKIVRRYRKNATTEALQSGADVKFQEFAEYLVDPGTQREAPLNEHWQTVYSLCHPCHIHYDLVGKYETLEDDANYVLKLVGEGDSLRFPSFAKSTRTTDQMAAMFFGNISSQQQSQLYQLYKLDYLMFNYSIPSYLKLQ
Protein: Transaldolase (FoTal) (EC 2.2.1.2) (J9MJK9)
Organism: Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato)
Function: Transaldolase important for the balance of metabolites in the pentose-phosphate pathway. Involved in xylose fermentation to ethanol.
Interaction partners:
- Glucose-6-phosphate isomerase
- Triosephosphate isomerase
- Transketolase
- Glyceraldehyde 3-phosphate dehydrogenase catalytic domain-containing protein
- Fructose-1,6-bisphosphatase
- ATP-dependent 6-phosphofructokinase
- Uncharacterized protein.
- Uncharacterized protein
- Alpha-D-phosphohexomutase alpha/beta/alpha domain-containing protein
- Enolase
Sequence:
MSSSLEQLKATGTTVVSDSGDFASIGKYKPQDATTNPSLILAASKKAEYAKLIDVAIDYAKQKGGPIDQQVDDALDRLLVEFGKEILKIIPGKVSTEVDARYSFDTEASVNKALHLIELYGEQGISKDRILIKIAATWEGIKAAEILQRDHGINTNLTLMFSLVQAIGAAEAGAYLISPFVGRILDWFKASTKKEYSKEEDPGVQSVKTIFNYYKKYGYNTIVMGASFRNTGEITELAGCDYLTISPNLLEELLNSNEPVPKKLDASQASSLDIEKKSYINDEALFRFDFNEDQMAVEKLREGISKFAADAVTLKSILKEKLA
Protein: Nudix hydrolase 22 (J3KQJ3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDPEVTLLLQCPGGGLPQEQIQAELSPAHDRRPLPGGDEAITAIWETRLKAQPWLFDAPKFRLHSATLAPIGSRGPQLLLRLGLTSYRDFLGTNWSSSAAWLRQQGATDWGDTQAYLADPLGVGAALATADDFLVFLRRSRQVAEAPGLVDVPGGHPEPQLDLWLSVRERTPDSGSLTLLHCATSDPQGQQALCPGGSPQHQDLAGQLVVHELFSSVLQEICDEVNLPLLTLSQPLLLGIARNETSAGRASAEFYVQCSLTSEQVRKHYLSGGPEAH
Protein: AT3g13440/MRP15_7 (S-adenosyl-L-methionine-dependent methyltransferases superfamily protein) (Q8VXU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Multifunctional methyltransferase subunit TRM112 homolog B
- Multifunctional methyltransferase subunit TRM112 homolog A
- Outer arm dynein light chain 1 protein
- ATPase GET3A
- T10F20.8 protein
- Peptide chain release factor 1
- Peptide chain release factor PrfB1, chloroplastic
- Iron-sulfur assembly protein IscA-like 2
- Peptide chain release factor PrfB3, chloroplastic
- Peptide chain release factor PrfB2, chloroplastic
Sequence:
MADQGLEESNPMDLSKHPSGIVPTPHSQVIYKMPPRIAAIRLVSSHREVYEPCDDSFALVDALLADRTNLIEHNPKICMEIGCGSGYVITSLILLLQNEVPGVHYLAIDTNPIATRVTKETLEAHGVNADVICADLATGLEKRLAGSVDVIVVNPPYVPTPEYEVGMEGIASAWAGGENGRTVIDKILPVVDLLLSEKGWFYLVTLTSNFPAEICLMMRKKGYASRIVVQRSTEEENLVILKFWRDKDEESQDKETSSSSFVSQFSKSLSSLMEKQWR
Protein: Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Q2F958)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}.
Interaction partners:
Sequence:
MTNLVRWLFSTNHKDIGTLYFIFGAIAGVMGTCFSVLIRMELARPGDQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGAPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGSGTGWTVYPPLSGITSHSGGAVDLAIFSLHLSGVSSILGSINFITTIFNMRGPGMTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSRKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWVGKIFGRTYPETLGQIHFWITFFGVNLTFFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGIRRFFVVVAITSSSGKNKRCAESPWAVEQNPTTLEWLVQSPPAFHTFGELPAIKETKS
Protein: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) (Q9LDD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- Isovaleryl-CoA dehydrogenase, mitochondrial
- Biotin carboxylase, chloroplastic
- Probable enoyl-CoA hydratase 2, mitochondrial
- Probable enoyl-CoA hydratase 1, peroxisomal
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- Probable acyl-CoA dehydrogenase IBR3
- 4-hydroxyphenylpyruvate dioxygenase
- 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial
Sequence:
MLRILGRRVVSASKELTSIQQWRIRPGTDSRPDPFRTFRGLQKGFCVGILPDGVDRNSEAFSSNSIAMEGILSELRSHIKKVLAGGGEEAVKRNRSRNKLLPRERIDRLLDPGSSFLELSQLAGHELYEEPLPSGGIITGIGPIHGRICMFMANDPTVKGGTYYPITIKKHLRAQEIAARCRLPCIYLVDSGGAYLPKQAEVFPDKENFGRVFYNESVMSSDGIPQIAIVLGSCTAGGAYIPAMADESVMVKGNGTIFLAGPPLVKAATGEEVSAEDLGGATVHCTVSGVSDYFAQDELHGLAIGRNIVKNLHMAAKQGMEGTFGSKNLVYKEPLYDINELRSIAPVDHKQQFDVRSIIARIVDGSEFDEFKKQYGTTLVTGFARIYGQTVGIIGNNGILFNESALKGAHFIELCSQRKIPLVFLQNITGFMVGSRAEANGIAKAGAKMVMAVSCAKVPKITIITGASFGAGNYAMCGRAYSPDFMFIWPNARIGIMGGAQAAGVLTQIERATKKRQGIKWTEEEEEAFKKKTVDAYEREANPYYSTARLWDDGVIDPCDTRKVLGLCLSAALNRPLEDTRFGVFRM
Protein: DH domain-containing protein (H2KYM2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MVIKCFTCLRKQSSEVWIVTADFDGQVEGHLTVHKGDRVEIVEDQATDCAEYVQVVLCDQPTKHGLVPASIIAPPESGSVPDRPDDSNASGSTVSKRKSLRRIFANSSKERAAAANSSSSNNNSPATRQSTSTSSPVTANGHTTESSTSAPIGVLSSGEPTSSNSIPSSSTPTHTVPSSVPATVIPIVVAEDEKAEDCLPPPMENITINNSIDEKDMNEDSVAASDAVEPEVALPAKVEKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMDLPADLVGKDKIIFANIVNILEFHKTNFLKEIEKCSENYEAAGAAFVKYERRLHTLYVTYCQNKPKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILKFTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRLQNFDKSLSAQGKLIHQGTLQISESIAGNVQKPKDRRIFLFEQSAIIADHIPPKKEFGNPTYIFKSQFMVNKMVFEPNVPDDPLRFVIKSSDPTQPTSFIANAQSQEEKDEWNRKMSELLDQQKRLLAALVDPRRYNDMSSGMGDLSLGAPGGDRRGAPSSANRSAASSSKKPAESPKKEGKSKSSLFSFGKKPAKSPTSPPPVGK
Protein: MAGUK p55 scaffold protein 4 (A0A087WUS1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLYKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ
Protein: Arrestin domain-containing protein 3 (Q7TPQ9)
Organism: Mus musculus (Mouse)
Function: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96B67}. Cell membrane {ECO:0000250|UniProtKB:Q96B67}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96B67}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96B67}. Lysosome {ECO:0000250|UniProtKB:Q96B67}. Endosome {ECO:0000250|UniProtKB:Q96B67}. Early endosome {ECO:0000250|UniProtKB:Q96B67}. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis. {ECO:0000250|UniProtKB:Q96B67}.
Interaction partners:
- E3 ubiquitin-protein ligase NEDD4
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- Beta-2 adrenergic receptor
- S-arrestin
Sequence:
MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLLLSLPLVIGTIPLHPFGSRTSSVSSQCSMSMNWLALALPERPEAPPSYAEVVTEEQRRNNLAPVGACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSSEDRPSCPSR
Protein: AT2G45990 protein (Expressed protein) (Ribosomal RNA small subunit methyltransferase G) (O82790)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At4g24700
- Protein trichome birefringence-like 12
- Expressed protein
- Small ribosomal subunit protein cS23z
- Maternal effect embryo arrest 9
- Small ribosomal subunit protein uS3x
- Flavin-containing monooxygenase FMO GS-OX3
- PHD finger protein ALFIN-LIKE 4
- Microtubule-associated protein 70-5
- Auxin-responsive protein SAUR66
Sequence:
MGDLYALDFDGVLCDSCGESSLSAVKAAKVRWPDLFEGVDSALEEWIVDQMHIVRPVVETGYENLLLVRLLLETKIPSIRKSSVAEGLTVDGILESWAKFKPVIMEAWDEDRDALVDLFGKVRDDWINKDLTTWIGANRFYPGVSDALKFASSKIYIVTTKQGRFAEALLREIAGVIIPSERIYGLGSGPKVEVLKLLQDKPEHQGLTLHFVEDRLATLKNVIKEPELDKWSLYLGTWGYNTEKERAEAAGIPRIQVIELSTFSNKLK
Protein: 6820431F20Rik protein (Q05CI6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLQRSKRGWVWNQFFVIDEYTGPNPVLVGRLHSDIDAGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNKPLGPPSEFIDKDQDINDNPPEFLREIYHTNVPERSNVGRNISYPSDSL
Protein: Artemin (Q6AYE8)
Organism: Rattus norvegicus (Rat)
Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9Z0L2}.
Interaction partners:
- GDNF family receptor alpha-1
- GDNF family receptor alpha-3
- Proto-oncogene tyrosine-protein kinase receptor Ret
- GDNF family receptor alpha-2
- GDNF family receptor alpha-4
- Beta-nerve growth factor
- Neurturin
- Syndecan-3
- Glial cell line-derived neurotrophic factor
- Neurotrophin-3
Sequence:
MELGLGEPTALSHCLRPRWQPALWPTLAALALLSSVTEASLDPMSRSPASRDVPSPVLAPPTDYLPGGHTAHLCSERALRPPPQSPQPAPPPPGPALQSPPAALRGARAARAGTRSSRARATDARGCRLRSQLVPVSALGLGHSSDELIRFRFCSGSCRRARSPHDLSLASLLDAGALRSPPGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLSATACGCLG
Protein: Homeobox protein Nkx-2.1 (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (P23441)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P50220}.
Interaction partners:
- Paired box protein Pax-8
- Pulmonary surfactant-associated protein B
- LIM homeobox 6
- Transcription factor GATA-6
- Surfactant protein C
- Thyroglobulin
- Forkhead box E1.
- Thyrotropin receptor
- Hepatocyte nuclear factor 3-alpha
- Mothers against decapentaplegic homolog 3
Sequence:
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW