wanglab/gogpt-training-data huggingface dataset:
Protein: U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) (Q9P794)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. usp103/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:16823372}.
Interaction partners:
- U1 snRNP-associated protein usp106
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein G
- Pre-mRNA-processing factor 39
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 snRNP-associated protein usp107
- Small nuclear ribonucleoprotein Sm D1
- U2 small nuclear ribonucleoprotein A'
Sequence:
MPRYLCDYCQVWLTHDSQSVRKAHNAGRAHIQNVQDYYTKVAQEEAQKQLEERASSGFLKKGNGSLDLPYAYAFPPKYNVFNLGCPPPPYIVSANTYMAPKGMNAMNAAAFVPMMPAVNLTNQVAFSAPQTTASSNTQLTQQQQSLPQTNEHQRARTHSNANNHFTKTHHQGQRSHQRFVRA
Protein: Molybdenum cofactor biosynthesis protein 1 [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)] (Q5RKZ7)
Organism: Mus musculus (Mouse)
Function: Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
Interaction partners:
- Molybdopterin synthase catalytic subunit
- GTP cyclohydrolase 1
- Gephyrin
- Sulfite oxidase, mitochondrial
- Guanylyl cyclase C
- Adenylate cyclase type 10
- Bis
- Adenylate cyclase type 6
- Adenylate cyclase type 4
- Ectonucleoside triphosphate diphosphohydrolase 8
Sequence:
MAARPAFGIVRQLLRSNARGCSSGAPVTQPRPGEPSRPTREGLSLRLQFLQEHAAPFSAFLTDSFGRQHSYLRISLTEKCNLRCQYCMPEEGVPLTPKADLLTTEEILTLARLFVKEGVDKIRLTGGEPLIRPDVVDIVARLHGLEGLRTIGLTTNGINLARLLPRLQQAGLNAVNISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYKPVKVNCVVMRGLNEDELLDFVALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTIRQRWPGLEKLPEEDSSTAKAFKIPGFQGQISFITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLRDHLRAGASEEELLRIIGAAVGRKKRQHAGMFNIAQMKNRPMILIGVLLMLQDSPPARWSNFSWDPLRVRNPSARQCLSDQMASLWKRHCIPKALPLSQQCLGSGSPQRHYSSYPDPDTHSKCLSTGSQAPDAPSGPGPTSNQLTHVDSAGRASMVDVGGKPETERVAVASAMVLLGPVAFKLVQQNQLKKGDALVVAQLAGVQAAKLTSQLIPLCHHVALSHVQVHLELDSTRHAVLIQASCRARGPTGVEMEALTSAAMAALTVYDMCKAVSRDIVVTEVKLISKTGGQRGDFHRA
Protein: Sulfhydryl oxidase 2 (EC 1.8.3.2) (Quiescin-sulfhydryl oxidase 2) (AtQSOX2) (Q9ZU40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Endoplasmic reticulum oxidoreductin-1
- Thioredoxin domain-containing protein 9 homolog
- Thioredoxin-like protein AAED1, chloroplastic
- Thioredoxin H9
- Peroxidase 18
- Mitochondrial import inner membrane translocase subunit TIM10
Sequence:
MSLVHLLLFAGLVIAASSSSPGSRLILREISDQKDKAVELNTTNFDSVLKDTPAKYAVVEFFAHWCPACRNYKPHYEKVARLFNGPDAIHPGIVLMTRVDCAMKTNTKLCDKFSVSHYPMLFWGPPTKFVSGSWEPKKDKSEILVIDDGRTAERLLNWINKQIGSSYGLDDQKFKNEHALSNLTDYNQISQAVYDVEEATAEAFDIILAHKAIKSSETSASFIRFIQLLAAHHLSRRCRKGAAEILVNYDDLCPSGNCSYEKSGGNDTLGNFPICGKDVPRGYYMFCRGSKNDTRGFSCGLWVLMHSLSVRIEDGESHFAFTTICDFVNNFFMCDECRLHFNDMCLSVKTPFKKARDFVLWVWSTHNKVNERLLKDEASLGTGDPKFPKIIWPPKELCPLCYLSSNQKSIEWDHEHVYKFLKNYYGPKLVSLYKEKSVSRSKEETVSATEDLTVATNALVVPIGAALAIAIASCAFGALACYWRTQQKNRKPRRR
Protein: Mitochondrial metal transporter 1 (Q03218)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial metal transporter involved in mitochondrial iron accumulation.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:9353309}; Multi-pass membrane protein {ECO:0000269|PubMed:9353309}.
Interaction partners:
Sequence:
MLRICVKRPCIKIVLSQVRPALLVRKENLHISTGVKVEKSSIINQKDPNKVRVEINELKRQAEIEKAAIKELEKNPQYQKLAEAFNSHDHVHLRESETEQNDIISLGTIRDYKSSKCEQADKPSSLNLHSHTHSHGHTHSHAAHNPLLVLSTEQIRKNAGVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISIGWSSLCALVGPVIPHTIIDTIGNLGHAHTYSEDIIEDVTDINAAWIAAASIAAKEWIFRATRKIAINTNSNVLMANAWHHRVDSLTSLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDPRYLEIETLVKDTLNKLISNNNSQKPYGLKELTLLSSGPNLRGHLTLEVPLQKWGNILGVNEFEIVTHHLRNVLTNEVSNLRRLDIEYVEEKNGEENEHIKGQQNYKEDVLIKHDHTNTHI
Protein: 3-ketoacyl-CoA synthase 20 (KCS-20) (EC 2.3.1.199) (Very long-chain fatty acid condensing enzyme 20) (VLCFA condensing enzyme 20) (Q9FG87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the synthesis of VLCFAs from 22 to 26 carbons in length (e.g. C22, C24, C26). Functionally redundant with KCS2 in the two-carbon elongation of C22 fatty acids that is required for cuticular wax and root suberin biosynthesis.
Subcellular location: Membrane {ECO:0000269|PubMed:15277688}; Multi-pass membrane protein {ECO:0000269|PubMed:15277688}.
Interaction partners:
- Very-long-chain 3-oxoacyl-CoA reductase 1
- Very-long-chain 3-oxoacyl-CoA reductase-like protein At1g24470
- Cytochrome P450 86B1
- Probable fatty acyl-CoA reductase 5
- Very-long-chain enoyl-CoA reductase
- Fatty acyl-CoA reductase
- Glycerol-3-phosphate acyltransferase 5
- Very-long-chain
- Cytochrome P450 86A1
- Very-long-chain aldehyde decarbonylase CER1
Sequence:
MSHNQNQPHRPVPVHVTNAEPNPNPNNLPNFLLSVRLKYVKLGYHYLISNALYILLLPLLAATIANLSSFTINDLSLLYNTLRFHFLSATLATALLISLSTAYFTTRPRRVFLLDFSCYKPDPSLICTRETFMDRSQRVGIFTEDNLAFQQKILERSGLGQKTYFPEALLRVPPNPCMEEARKEAETVMFGAIDAVLEKTGVKPKDIGILVVNCSLFNPTPSLSAMIVNKYKLRGNILSYNLGGMGCSAGLISIDLAKQMLQVQPNSYALVVSTENITLNWYLGNDRSMLLSNCIFRMGGAAVLLSNRSSDRSRSKYQLIHTVRTHKGADDNAFGCVYQREDNNAEETGKIGVSLSKNLMAIAGEALKTNITTLGPLVLPMSEQLLFFATLVARKVFKVKKIKPYIPDFKLAFEHFCIHAGGRAVLDEIEKNLDLSEWHMEPSRMTLNRFGNTSSSSLWYELAYSEAKGRIKRGDRTWQIAFGSGFKCNSAVWKALRTIDPMDEKTNPWIDEIDDFPVQVPRITPITSS
Protein: Mitochondrial import inner membrane translocase subunit TIM44-1 (Q1PF33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM23-1
- Mitochondrial import inner membrane translocase subunit PAM16 like 1
- Mitochondrial import inner membrane translocase subunit TIM23-3
- Mitochondrial import inner membrane translocase subunit TIM23-2
- Mitochondrial import inner membrane translocase subunit TIM14-3
- Mitochondrial import inner membrane translocase subunit TIM14-1
- Mitochondrial import inner membrane translocase subunit PAM16 like 2
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM17-2
- Mitochondrial import inner membrane translocase subunit TIM14-2
Sequence:
MAIRKIIRDLLITKQPLLRQLFHQRVLRANARSEFLPAIGYTSHRRFSVFTEFSKNIRGEAHSNPEFERTVKELKERTEEFKGVTEDLKVRTKQTTEKLYKQADGVWTEAESAAKKVSSSVKDKLSAASEEVKESFKLGKEENAESASSSGTRASQGEKQQSGSTEELHTFFAKFKSSLSSPKVSEVFYRLKEAKPFDIVKQALDIVKDELRGNPSRKKFLEHTPPPPFTGERSMRTEMVVTQTKQSKLQQKWESFREKMQGSPVFKRLSGMSEPVVNKSQEIAEDVREIWETSDNPIVHKIQDMNEKFLKETDSASTYKEIRSRDPSFSLPDFAAEIEEVIKPVLNAYSEGDVETLKKYCSKEVIERCTAERTAYQTHGVLFDNKLLHISEVSVSVTKMMGDSPIIIAKFQTQEIYCVRDENGEIQEGGQDTIHTVYHEWAMQQVETTELGEDAIYPIWRLREMCRNGVQALI
Protein: Protein kintoun (Dynein assembly factor 2, axonemal) (Q9NVR5)
Organism: Homo sapiens (Human)
Function: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069, ECO:0000269|PubMed:19052621}. Dynein axonemal particle {ECO:0000250|UniProtKB:B1H1W9}. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. {ECO:0000255|HAMAP-Rule:MF_03069}.
Interaction partners:
- Dynein axonemal intermediate chain 2
- Dynein axonemal intermediate chain 1
- Dynein axonemal assembly factor 1
- Radial spoke head protein 4 homolog A
- Radial spoke head protein 9 homolog
- Dynein axonemal heavy chain 5
- Dynein axonemal assembly factor 6
- Thioredoxin domain-containing protein 3
- Dynein axonemal heavy chain 11
- Dynein axonemal assembly factor 4
Sequence:
MAKAAASSSLEDLDLSGEEVQRLTSAFQDPEFRRMFSQYAEELTDPENRRRYEAEITALERERGVEVRFVHPEPGHVLRTSLDGARRCFVNVCSNALVGAPSSRPGSGGDRGAAPGSHWSLPYSLAPGREYAGRSSSRYMVYDVVFHPDALALARRHEGFRQMLDATALEAVEKQFGVKLDRRNAKTLKAKYKGTPEAAVLRTPLPGVIPARPDGEPKGPLPDFPYPYQYPAAPGPRAPSPPEAALQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPSPVPHELVITIELPLLRSAEQAALEVTRKLLCLDSRKPDYRLRLSLPYPVDDGRGKAQFNKARRQLVVTLPVVLPAARREPAVAVAAAAPEESADRSGTDGQACASAREGEAGPARSRAEDGGHDTCVAGAAGSGVTTLGDPEVAPPPAAAGEERVPKPGEQDLSRHAGSPPGSVEEPSPGGENSPGGGGSPCLSSRSLAWGSSAGRESARGDSSVETREESEGTGGQRSACAMGGPGTKSGEPLCPPLLCNQDKETLTLLIQVPRIQPQSLQGDLNPLWYKLRFSAQDLVYSFFLQFAPENKLSTTEPVISISSNNAVIELAKSPESHGHWREWYYGVNNDSLEERLFVNEENVNEFLEEVLSSPFKQSMSLTPPLIEVLQVTDNKIQINAKLQECSNSDQLQGKEERVNEESHLTEKEYIEHCNTPTTDSDSSIAVKALQIDSFGLVTCFQQESLDVSQMILGKSQQPESKMQSEFIKEKSATCSNEEKDNLNESVITEEKETDGDHLSSLLNKTTVHNIPGFDSIKETNMQDGSVQVIKDHVTNCAFSFQNSLLYDLD
Protein: Retinoic acid early transcript 1L (Q6AYE9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MAKRGTTKCNLSLSLGLLLLLNFLGTAMLEDVHSLSCNLIIRSPTKAEPLWYEGQCSMDGIDFLSFNNVNKTMPLGNQEKMANATEVWTCVTQWIDLLGQDLRDKVSEIKGDTTKTSGHPTLWVTMLSNHSHRHIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDATLMKHLNLSIAECSQKFNEFLNQHEERTRSRTRAPDIAQPPPTRQFPYKEVLIPVVLIIFIIFICICVKRMCCTQGGRELQLLKDYYINLHKPQRNEGLEETKGEVPNQSTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS
Protein: Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein) (Q0VAQ4)
Organism: Homo sapiens (Human)
Function: May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15021913}; Single-pass type III membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15986429}; Single-pass type III membrane protein {ECO:0000255}. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions (PubMed:15021913). Detected on cytoplasmic membranes in undifferentiated tumors (PubMed:15986429). {ECO:0000269|PubMed:15021913, ECO:0000269|PubMed:15986429}.
Interaction partners:
Sequence:
MTSLLTTPSPREELMTTPILQPTEALSPEDGASTALIAVVITVVFLTLLSVVILIFFYLYKNKGSYVTYEPTEGEPSAIVQMESDLAKGSEKEEYFI
Protein: Uncharacterized protein C9E9.15 (O14297)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- mRNA export factor elf1
- Elongation factor 3
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL24
Sequence:
MLVLFGQPENWHEQDFRAVDDRVRGGSSISHLTEEKDSDGKSRAKFWGTLDTKTLGGAGFCSQATNIKDRTWNLKEFKGIELDIAKSDSYKYTFIIKDCHQDWETSDEKSSLSYEYDFTPIYSKEDQVVSIPFSEFKPTYRGRPVEGAPELDVSKITQFSIMIRSFFNSQSGDYELVLNSIRAIPKNVPFTTHKMSNEKQRLFDDYEKEIAGGSWCICQ
Protein: Low-density lipoprotein receptor-related protein (A0A0G2K0H3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Sclerostin
- Protein Wnt
- Dickkopf homolog 1
- Protein Wnt
- Dickkopf WNT signaling pathway inhibitor 2
- LDL receptor related protein 5
- Dickkopf WNT signaling pathway inhibitor 4
- Protein Wnt
- Frizzled-4
- Frizzled-8
Sequence:
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
Protein: Cadherin-6 (Q3KNZ1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
Interaction partners:
Sequence:
MRTYRYFLLLFWVGQPYPTFSNPLSKRTSGFPAKRKALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAVNRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHEMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPHVEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQIREDARINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLRAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAMEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGMDSDKDS
Protein: Bms1-type G domain-containing protein (Q384C0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Nrap protein domain-containing protein
- PNO1 second type I KH domain-containing protein
- Uncharacterized protein
- DDB1- and CUL4-associated factor 13
- Bystin, putative
- Nop14-like protein
- CCAAT-binding factor domain-containing protein
- rRNA biogenesis protein, putative
- RNA 3'-terminal phosphate cyclase-like protein
- U3 small nucleolar ribonucleoprotein protein MPP10, putative
Sequence:
MGADDEQQRNKSHKARVVGSKAVKKEEYRKKKAGIELQPNRGSNTKAFQGPTASSRKGQQLLRSLEKRETALHVPVVDKTLRHVVAEPPLLVAVVGPPGVGKSTLIRSMVKFYSNRNVQVVRGLITVVAGRSRRVTFLECPNTLTAMCDVAKVADLILLMVDGSFGFEMETFEFLNIAQVHGFPRMFGIVSHLDQLKTGKALRKKKRFLRHRFWHEVAAGAKVLCLAPMVRGMYRSTDVLKLHRLLICVEPKIQNWRNTHSCVVVDRYEDITAPQNVVDNEKCNRTIAFYGYARGRPMKVEQLVHIPGLGDFPIMHLSHQDDPCAFDEKNARGESKSQGHKMRHLGMKQKRIYAPYCDVSGVVYDDDAIYIQEDAEKSTIERSGEGLRLIRDLQRVKPIDAAATALEVVRRPVVFRGEDTMELDMGDVKGSNTSVSDDGEEKATESSDDSDWDSGEMASSAAAVKKDLLLYGPGGGDDGLRVNNPSADDAAGLAPRGRGAPDSVRENTIRNDWSNTDLLRRLKNLFVTGNWDSPNDDVGDAASSGAETEGSKGYESEDEEFDAIIRGEAPLDSTNVKDEHEENVDDEGNAETDEEEWDGDGETTDWGAFRPRDALANVGHTSKGTVPHMRNFRAAEAYGSITGGRKGADNDDMTDGSCYDILAEEGDDAVVDSAALSDPELDGLVATFLAPHDASAKRAETSSAALRDDDDSAIQFYDPNHFSKKNDTADDHNDEMEETTAIVGGKPLTEEQERLLQKRMAKKKAFNELYDMGGKNNTYSHYHEMTREVEAKKERLDTALQEVGHDITNKIKLVGHFSGLYVRFVLENVPVEFVQLFDPSVPIIAGGVNAGEDQFQVVHAKLKRHRWFPKILKAQDPLLLSMGWRRFQTQPILATEDPNGRMRYLKYTPMHMHCAAAFYAPVAPANTGFVAIPVREQRSPNFRISCTGYTVGNDLASNIVKKLKLIGTPQKIMKTTAFIKGMFNSDLEAAKYVGAKLKTVAGIRGIVKTVLKGKNGLIRATFEDKIFPSDIVFCRAWKMVEPPKYCSIQRNLVDAEWVGMRPMRELRWAHGVPLESKSDSEYREIRRRNRATVDDDDGKGKTPDVLLSRNQRLKLPFSLKEEYIPLKRSTALQEQIAGATTVAPEPRDMRRTALLDILNEKTEAMWRKKVEAKKRVRERHLRESKAEEEEYQRRLKKAKKETARLREFRSQHKSRK
Protein: Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) (P31662)
Organism: Rattus norvegicus (Rat)
Function: Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18768736, ECO:0000269|PubMed:19147495}; Multi-pass membrane protein {ECO:0000269|PubMed:18768736, ECO:0000269|PubMed:19147495}. Postsynapse {ECO:0000250|UniProtKB:Q8BJI1}. Presynapse {ECO:0000250|UniProtKB:Q8BJI1}. Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. {ECO:0000250|UniProtKB:Q8BJI1}.
Interaction partners:
Sequence:
MPKNSKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGETGGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVVFILRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLESSSHPNGRYGSGYLLASTPESEL
Protein: Phosphatidylinositol binding clathrin assembly protein (H0YEF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATT
Protein: [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) (M0RB75)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Estrogen receptor
- Lysine-specific demethylase 3A
- Lysine-specific demethylase 6B demethylase 6B)
- Histone H3.3
- Lysine-specific histone demethylase
- Histone H3.1
- Histone H3
- Histone H3
Sequence:
MGSEDHSAQNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGNLRSILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYEQWKQGRDLTVLDHTRPTALSSPELSSWSASRTSLKAKLLRRQISVKESRPWRKAEEERRPSLERRREPTRRPGPASHRRRSQPKKSKPEDSRSPGEATAGVAGLDEARGCSRRETMPEEEEEEELSPSQGHEAEGVEEDGRGKPRPTKARSKKKTPSLLSPPLLSAPPALFPAEEVLRLPPQPKSPGPAMGPMAAEGGPPPTALNVVPPGVPGEETEVRPRPIIPMLYVLPRANSSDGDREHAAHPQLAPMELGPEEEDQAQAGDSQGTTSFSKLKVEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEAFPFSGEDDGSDPEALRSLLSLQWKSKAASFQAERKLNAAAALSEPYCAVCTLFYPYSQSVQTEREVLATPGDSAVQPPSKSGQRTRPLIPEMCFTSSGENTEPLPANSYVGEDGTSPLISCAHCCLQVHASCYGVRPELAKEGWTCSRCAAHAWTAECCLCNLRGGALQRTTEHRWIHVICAIAVPEVRFLNVIERNPVDVSAIPEQRWKLKCVYCRKRMKRVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHRASGAGGQLLRTVSLGQIVITKNRNGLYYRCRVIGTTAQTFYEVNFDDGSYSDNLYPESITSRDCLRLGPPPEGELVELRWTDGNLYRARFISMATSLIYQVEFEDGSQLTVKRADIFTLEEELPKRVRSRLSLSTGTPQEPSFSGDGVKAAKRPRVATVLATTTEDTGRSPEYLAFMESLLQAQGQPGAPF
Protein: Early growth response protein (Q546S1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363046}.
Interaction partners:
Sequence:
MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC
Protein: Cyclic GMP-AMP synthase-like receptor (cGLR) (EC 2.7.7.-) (P0DV11)
Organism: Drosophila eugracilis (Fruit fly)
Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (By similarity). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA longer than 15 bp, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish).
Interaction partners:
Sequence:
MENFAEKKISKPLTFGEGIQYVLDRISIKPEDRQTFKEDAQQIQNEFVRAISKQDPYFASAFRGLALTGSSLDNVRINLPDEFDMLTKIKMPCKLEPVPIRSHPGYVFLRASGDNIPIHLVDRWEDEYCIDRLKVQAWFRDNITAVIPELSNIRCNDGRSYELVNKTIGDVAHTIQAKCLSDPDRSISFDFVPAFEFSASEWPRIFPQHRNEDRSWYAVPSEFKYPNVGDDPLSFLVCAPYWERMVLTKKQHLKDGYRLMKAMRDANDMPKIYSYTIKSVFLNASNVNKLINWNQSPGRILIRAIDLLAMFLRKGKLPSYLVPDRNMLDRLSVDMRQDYRRKLCHIFRRLIRCRDRDCMTSEDLQFIFGMRY
Protein: Glutamate receptor (Q71E63)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
Interaction partners:
Sequence:
MILSGLLLPALWGLALGGSPSVQIGGLFPRGADQEYSAFRIGMVQFGTAEFRLTPHIDNLEVANSFAITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITPSFPADGLNQFVLQMRPDIKGPLISLVEYYKWEKFAYLYDSDRGLSTLQAVLDTAAERKWQVTAINVGNLKDEWKDEAYRSLFQDLENKNERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANFGFVDGDLSKIQYGGANVSGFQIVDFDDPLVAKFDQRWEALEEKEYPGADSRIRYTSALTYDAVQVMTEAFRFLHKQRIDISRRGNNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGRRVNYTVNVMELKNSGPVKIGYWNEMDKMAVTKSDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAELFTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGESKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKRMKVAKTQALNPSSSSQNSQNFATYKEGYNVYGLESVKI