wanglab/gogpt-training-data huggingface dataset:
Protein: Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] (P35573)
Organism: Homo sapiens (Human)
Function: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17908927}. Note=Under glycogenolytic conditions localizes to the nucleus.
Interaction partners:
- Glycogen phosphorylase, brain form
- Glycogen phosphorylase, liver form
- Glycogen phosphorylase, muscle form
- 1,4-alpha-glucan-branching enzyme
- Ribosome biogenesis protein NOP53
- Glycogenin-2
- UTP--glucose-1-phosphate uridylyltransferase
- demerged
- Alpha-amylase 2B
- Pancreatic alpha-amylase
Sequence:
MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQGKAVTVYTNYPFPGETFNREKFRSLDWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKSGGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLANQLELNPDFSRPNRKYTWNDVGQLVEKLKKEWNVICITDVVYNHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWRFSCDVAEGKYKEKGIPALIENDHHMNSIRKIIWEDIFPKLKLWEFFQVDVNKAVEQFRRLLTQENRRVTKSDPNQHLTIIQDPEYRRFGCTVDMNIALTTFIPHDKGPAAIEECCNWFHKRMEELNSEKHRLINYHQEQAVNCLLGNVFYERLAGHGPKLGPVTRKHPLVTRYFTFPFEEIDFSMEESMIHLPNKACFLMAHNGWVMGDDPLRNFAEPGSEVYLRRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITATYFQGVRLDNCHSTPLHVAEYMLDAARNLQPNLYVVAELFTGSEDLDNVFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDITHDNECPIVHRSAYDALPSTTIVSMACCASGSTRGYDELVPHQISVVSEERFYTKWNPEALPSNTGEVNFQSGIIAARCAISKLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTKPYRKDENSINGTPDITVEIREHIQLNESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHAQVAVGILRNHLTQFSPHFKSGSLAVDNADPILKIPFASLASRLTLAELNQILYRCESEEKEDGGGCYDIPNWSALKYAGLQGLMSVLAEIRPKNDLGHPFCNNLRSGDWMIDYVSNRLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDTAWKQMSSFVQNGSTFVKHLSLGSVQLCGVGKFPSLPILSPALMDVPYRLNEITKEKEQCCVSLAAGLPHFSSGIFRCWGRDTFIALRGILLITGRYVEARNIILAFAGTLRHGLIPNLLGEGIYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFEVIQEAMQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGVDEETGFVYGGNRFNCGTWMDKMGESDRARNRGIPATPRDGSAVEIVGLSKSAVRWLLELSKKNIFPYHEVTVKRHGKAIKVSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVVAPELFTTEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLAKGFNYHQGPEWLWPIGYFLRAKLYFSRLMGPETTAKTIVLVKNVLSRHYVHLERSPWKGLPELTNENAQYCPFSCETQAWSIATILETLYDL
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8) (P13706)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm.
Interaction partners:
- Dihydroxyacetone phosphate acyltransferase
- BcDNA.GH07066
- Alcohol dehydrogenase
- Glycerol-3-phosphate acyltransferase 4, isoform D
- Phospholipid/glycerol acyltransferase domain-containing protein
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase 1
- 1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform A
- 1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E
Sequence:
MADKVNVCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGGIDLISHIITRHLKIPCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKFPLFTAIHKICTNQLKPNDLIDCIRNHPEHMDTSIMPSPKLQNL
Protein: Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) (P60878)
Organism: Gallus gallus (Chicken)
Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity).
Subcellular location: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P60881}. Note=Membrane association requires palmitoylation. {ECO:0000250}.
Interaction partners:
- Uncharacterized protein
- Syntaxin 1A
- Synaptotagmin-1
- Vesicle-associated membrane protein 3
- V-SNARE coiled-coil homology domain-containing protein.
- Syntaxin-binding protein 1
- Vesicle-associated membrane protein 7
- SNARE-associated protein Snapin
- Uncharacterized protein.
- NSF attachment protein alpha
Sequence:
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Protein: Ribulose bisphosphate carboxylase small subunit 2B, chloroplastic (RuBisCO small subunit 2B) (P10797)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
Subcellular location: Plastid, chloroplast {ECO:0000255|HAMAP-Rule:MF_00860}.
Interaction partners:
- Ribulose bisphosphate carboxylase large chain
- Phosphoribulokinase, chloroplastic
- Ribulose bisphosphate carboxylase small subunit 3B, chloroplastic
- Phosphoglycerate kinase 1, chloroplastic
- Phosphoglycolate phosphatase 1A, chloroplastic
- Ribulose bisphosphate carboxylase large chain, catalytic domain-containing protein
- Phosphoglycerate kinase 2, chloroplastic
- Phosphoglycerate kinase 3, cytosolic
- Phosphoglycolate phosphatase 2
- D-glycerate 3-kinase, chloroplastic
Sequence:
MASSMFSSTAVVTSPAQATMVAPFTGLKSSASFPVTRKANNDITSITSNGGRVSCMKVWPPIGKKKFETLSYLPDLSDVELAKEVDYLLRNKWIPCVEFELEHGFVYREHGNTPGYYDGRYWTMWKLPLFGCTDSAQVLKEVEECKKEYPGAFIRIIGFDNTRQVQCISFIAYKPPSFTEA
Protein: Heterogeneous nuclear ribonucleoprotein D (F1Q8A5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine/arginine-rich splicing factor 2
- Serine/arginine-rich splicing factor 2
- Serine and arginine-rich-splicing factor 4
- Heterogeneous nuclear ribonucleoprotein M
Sequence:
MSEEQFLGEDPTMKMEENDDGEGFGEEQMSGDNGGQGEAEGSKIDASKNEEDEGKMFVGGLSWDTTKKDLKDYFTKFGEVVDCTLKLDPLTGRSRGFGFVLFKEAESVEKVITQKEHKLNGKVIDPKKAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFDAYGEVESIELPMENKTNKRRGFCFITFKEEEPVKKIMEKKYHNIGLSKCEVKVAMSKEQYQQQQQWGGRGGYTSRGRGRGGPNQNWNQGYGNYWNQGYGNYGNYGYNNQGYGGYGGYDYSGYNNYYGYGDYSNQQSGYGKSQRRGGHQNSYKPY
Protein: COX assembly mitochondrial protein (Q9LFR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|RuleBase:RU364104}.
Interaction partners:
- Ribosomal protein L31
- Ribosomal protein L18e/L15 superfamily protein
- At3g05070
- AT5g03660/F17C15_80)
- Defensin-like protein 196
- Uveal autoantigen with coiled-coil/ankyrin
- Small ribosomal subunit protein uS17y
- NADH dehydrogenase 1 beta subcomplex subunit 7
- Prefoldin subunit 6
- ATP synthase subunit d, mitochondrial
Sequence:
MGSYVEQARENHVKKKVEEALRSKMKAKALMECDQYVSKYAQCATGRTFSVVWTCRKQARELNTCLHQFTNDNVLEEMKRAYMVQEEGKVSASAI
Protein: Glycine N-acyltransferase-like protein (EC 2.3.1.-) (Q22371)
Organism: Caenorhabditis elegans
Interaction partners:
- Glycine N-acyltransferase-like protein
Sequence:
MKATLIEITTRENLRRAQAQCSRHVSAIYFPFSIHTQLEDSFPESPVRVFVYPNISHPKMFFMFKDNEFIKPTLALAQVSGTSMNRLELIDLINEFRTRVFGAKRQPHLVIAEEHLIKMYGVAMRLSSSDWTNNDLRLSLFYMTESQKKLAMTTPLPNVPHGYYYDEIEPTEEAEIVNNTWKHAGAGDLEQTMAKLLRLPSSCVRFNGKPVAFEMIDPAGFFNNQYVFEDHRRKGLGNAVEMDLIHKTLSIGFSPFKTVAKDNKIVLDASIANKLWTMWSDEDGNAKTIVFQTWRCD
Protein: Cellular tumor antigen p53 (J3KP33)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}. Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}. Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQKTFPARHGGSHL
Protein: Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) (O94966)
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19465887}; Single-pass membrane protein {ECO:0000269|PubMed:19465887}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF123
- E3 ubiquitin-protein ligase SIAH1
- Heat shock protein HSP 90-alpha
- Baculoviral IAP repeat-containing protein 3
- Hypoxia-inducible factor 1-alpha
- Ubiquitin carboxyl-terminal hydrolase 13
- Baculoviral IAP repeat-containing protein 2
- Heat shock protein HSP 90-beta
Sequence:
MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR
Protein: GATA-binding factor 6-B (Transcription factor xGATA-6b) (P70005)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional activator that binds 5'-GATA-3'-containing motifs within gene promoters. Regulates cardiac-specific transcription during embryogenesis and thereby cardiogenesis.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MYQTLTITAAQGPLGYDPSPGTFMHSAASSPVYVPTSRVGSMLTSISYLQGTGASQGTHSVNSHWSQATSESSSYSSSSPHPSSRYHYSPSPPMANGSTRDTGYSSSLAVSGRDQYAPLARPLNGSYGSPYTPYMTPQLTSAWPAGPFDNTMLHSLQSRGAPISVRGAPGDVLDELPESRECVNCGSVQTPLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRIGLACANCHTTTTTLWRRNTEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNLNKSKSSSSNGNSSHHITMTPTSTTSSTNSDDCIKNGSPSQNTAPVVTSSLMSAQQTGSASPDSNILKYTGQDGLYSAVSLSSASEVAASVRQDSWCALALA
Protein: Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb (Semaphorin-3F isoform X1) (A0A2R8Q5T8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Neuropilin-1a
- Neuropilin
- Neuropilin
Sequence:
MLLDSLWPVQVLLVLSVLTLVLGNEPQNAPRVFLSFKDLRSTGTAHYFSFLLNTSDYRILRMDEDHDRMYVGSKDYILSLDLHDINREPLIIHWPVSPQRKTECVLSGKDTNGECGNFIRLIEPWNRTHLYICGTGAYNPVCTYVNRGRKPMTAMHLQMPQTRGRASRAAEPETVFDETGLQEYVFHLEPGKEDSGKGKCPYDPKLNSVSALINGELYAGVYIDFMGTDSAIFRTLGKNAVMRTDQYNSRWLNDPSFVHVHLIPDSGEKNDDKLYFFFREKSSEMGQSPKSQSRIGRICLNDDGGHCCLVNKWSTFLKARLICSVPGADGIETHFDELRDVYIQPTQDTKNPVIYGVFSVSGSVFKGSAVCVYSMADIRMVFNGPFAHKEGPNYQWVAYTGKIPYPRPGTCPGGTFTPNMKSTKDYPDEVINFMRNHPTMYNSVYPVHKRPLVVRTNVDYEFTTITVDQVTAADGNYEVLFLGTDRGTVQKVIVLPSDDLQTEELVLEEVEVFKVPTSITTMKISSKRQQLYVASAVGVTHMALHRCDVYGEACADCCLARDPYCAWDGKSCSRYSASQKRLPFRRSRRQDVKYGNPIRQCRGYNSNINKNTLETVQYGVEGSSTFLECQARSPHAAIKWHLHRDNSDRRREVRSDGRVLKTDQGLLLRSLQSSDSGIYICTATEKNFKHTLVKLQLLVLTNQAVNNILVDTGRPVVSPLQSSAWTPSAGQYKDLLTILSQPEMGLINQYCQDYWQYGDPLTGVIKAKDLKELKEQKKPRNRRHHGDEEET
Protein: Topoisomerase I damage affected protein 7 (Q6FNJ6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Vacuole membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MIHNSSYTEAADIKSLSSFIEESSRVPDYISESNNIGWSSNINNPPLFESSSFDITTQNDNWILTETMQNITTESSSTFSRSVASSVFPSSSQAFVSPPSIIDIPISSIPESSSISISSDVLSSAITVSQTSSSSYSSLISSYSTIQSTSSSSISENEISSSSRISPGLLSSVPSITTSFSSGISSSVSPTSSLQQIAEQSSNSSLAENDLLSSSLTILSSVLSSSVLLHNSGVSSSSFTDNFSSTLTNSSNSLAILSSISESSLINTITDLPSSSVLLSPNNSESSIKVSSASSSSSRRKASTYTTPSRIPFSNSSEWYTPLPTPSISSSTNDTSSLLSELALIGISSSSSSSSSSQFYTSSTSSSSLVSSSENYSSSQPTTIEPITSTISSSYSDLSNDGEILSSTLGKSVYYSYIQTFDITASTTTFETALPIVTAFNLKDSYTFSKPSSIITTDLHFYKDWLSGALDSNEENGNKSKNAGTIAGSVVGSVVGLLVCTLIVWYFYIRKRRRNQKWKSFEVPSRSKDVEYNNNDNPFNNEFDFQHRVPPPLPPQRKNHNSIGVPPSSMGLSNTRSADYHMRFSYISSSTDSSDDYSDSMQSALHIGSDSGRERSNDVPEMGYLREII
Protein: Amoebiasin-2 (Cysteine protease inhibitor 2) (EhICP2) (ICP-2) (Q4GZL2)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: Cysteine protease inhibitor. Inhibits cysteine proteases CP1, CP2 and to a lesser extent CP5.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:16802137}. Lysosome {ECO:0000269|PubMed:16979632, ECO:0000269|PubMed:21440496}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:16979632}. Note=Upon host erythrocyte engulfment, localizes to phagosomes. {ECO:0000269|PubMed:16979632}.
Interaction partners:
Sequence:
MKQFIFFALLCTSTYAAIHILTEKEDHATLHISFNDLIKIQLRTNPSTGYAWNIEYPTDTFSLSQDTIKAEPHPSGMVGFPSIREIQLKPLKVGTTTIKLGYSRPWEKGKEPLRSLTYSVVIR
Protein: Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) (DNA polymerase III subunit beta) (Mtb beta-clamp) (P9WNU1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication (By similarity). Binds ds- and ssDNA. Binds the antibiotic griselimycin and its derivatives with high affinity (1.0 x 10(-10) to 2.0 x 10(-10) M sec(-1)). Binding occurs in a hydrophobic cleft between domains 2 and 3, which have been shown to be responsible for binding DNA polymerases and other DNA-modifying proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P0A988}.
Interaction partners:
- Chromosomal replication initiator protein DnaA
- DNA polymerase I
- DNA polymerase III subunit gamma/tau
- DNA polymerase III subunit alpha
- DNA replication and repair protein RecF
- Probable DNA polymerase III subunit delta
- DNA polymerase III subunit delta'
- Probable DNA polymerase III
- Putative bifunctional exonuclease/endonuclease protein Rv2191
- DNA gyrase subunit B
Sequence:
MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVRLPG
Protein: Germin-like protein subfamily 2 member 2 (Q9FZ27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250}.
Interaction partners:
- MD-2-related lipid recognition domain-containing protein
- Homeobox-leucine zipper protein GLABRA 2
- Probable cysteine protease RD19B
- MYB transcription factor-like protein
- Dof zinc finger protein DOF4.4
- Germination-specific cysteine protease 1
Sequence:
MMNSRISIIIALSCIMITSIRAYDPDALQDLCVADKSHGTKLNGFPCKETLNITESDFFFAGISKPAVINSTMGSAVTGANVEKIPGLNTLSVSLARIDYAPGGLNPPHTHPRATEVVYVLEGELEVGFITTANKLFTKTIKIGEVFVFPRGLVHFQKNNGKSPASVLSAFNSQLPGTASVAATLFAAEPALPEDVLTKTFQVGSKMVDKIKERLATKK
Protein: Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc)) (P14137)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:21075169, ECO:0000269|PubMed:2170421, ECO:0000269|PubMed:3948785}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000269|PubMed:3948785}.
Interaction partners:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- Adrenodoxin, mitochondrial
- 25-hydroxycholesterol 7-alpha-hydroxylase
- Steroidogenic acute regulatory protein, mitochondrial
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Steroid 21-hydroxylase
- Steryl-sulfatase
- Sulfotransferase 2B1
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
Protein: Transcription factor SOX-8 (P57073)
Organism: Homo sapiens (Human)
Function: Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Oligodendrocyte transcription factor 1
- Oligodendrocyte transcription factor 2
Sequence:
MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAKAGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLLNGLALPPAHSPTSHWDQPVYTTLTRP
Protein: Homeobox-leucine zipper protein ATHB-8 (HD-ZIP protein ATHB-8) (Homeodomain transcription factor ATHB-8) (Q39123)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the regulation of vascular development. May promote differentiation of precambial and cambial cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Auxin response factor 5
- Thermospermine synthase ACAULIS5
- Leucine-rich repeat receptor-like protein kinase TDR
- Transcription factor AIG1
- Dof zinc finger protein DOF5.3
- WUSCHEL-related homeobox 4
- Transcription factor LHW
- Prohibitin-6, mitochondrial
- Transcription repressor KAN1
- Homeobox-leucine zipper protein HAT4
Sequence:
MGGGSNNSHNMDNGKYVRYTPEQVEALERLYNDCPKPSSMRRQQLIRECPILSNIEPKQIKVWFQNRRCREKQRKEASRLQAVNRKLTAMNKLLMEENDRLQKQVSHLVYENSYFRQHPQNQGNLATTDTSCESVVTSGQHHLTPQHQPRDASPAGLLSIADETLTEFISKATGTAVEWVQMPGMKPGPDSIGIVAISHGCTGIAARACGLVGLDPTRVAEILKDKPCWLRDCRSLDIVNVLSTANGGTLELIYMQLYAPTTLAPARDFWMLRYTSVMEDGSLVICERSLNNTQNGPSMPPSPHFVRAEILPSGYLIRPCEGGGSILHIVDHFDLEPWSVPEVLRSLYESSTLLAQRTTMAALRYLRQISQEISQPNVTGWGRRPAALRALSQRLSKGFNEAVNGFSDEGWSILESDGIDDVTLLVNSSPTKMMMTSSLPFANGYTSMPSAVLCAKASMLLQNVPPSILLRFLREHRQEWADNSIDAYSAAAIKAGPCSLPIPRPGSFGGQVILPLAHTIENEEFMEVIKLESLGHYQEDMMMPADIFLLQMCSGVDENAVESCAELIFAPIDASFSDDAPIIPSGFRIIPLDSKSEGLSPNRTLDLASALDVGSRTAGDSCGSRGNSKSVMTIAFQLAFEMHMQENVASMARQYVRSVIASVQRVALALSPSSHQLSGLRPPPASPEAHTLARWISHSYRCYLGVDLLKPHGTDLLKSLWHHPDAVMCCSLKALSPVFTFANQAGLDMLETTLVALQDITLDKIFDNNNGKKTLSSEFPQIMQQGFMCMDGGICMSSMGRAVTYEKAVGWKVLNDDEDPHCICFMFLNWSFI
Protein: P2X purinoceptor 4a (F8W463)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q99571}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q99571}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSESVGCCDSVSQCFFDYYTSKILIIRSKKVGTLNRFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADYIIPPQEDGSFFVLTNMIITTNQTQSKCAENPTPASTCTSHRDCKRGFNDARGDGVRTGRCVSYSASVKTCEVLSWCPLEKIVDPPNPPLLADAENFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRKTDPDCPIFRLGDIVGEAEEDFQIMAVHGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVAPGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNIIPTLLNMGAGLALLGLVNVICDWIVLTFMKRKQHYKEQKYTYVDDFGLLHNEDK