wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein DLX-1 (P56177)
Organism: Homo sapiens (Human)
Function: Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:14671321}.
Interaction partners:
- Homeobox protein DLX-2
- Achaete-scute homolog 1
- Calretinin
- Myelin transcription factor 1-like protein
- LIM/homeobox protein Lhx6
Sequence:
MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHCLHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLEDPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNPNSSSGKGSGGNAGSYIPSYTSWYPSAHQEAMQQPQLM
Protein: Serine/threonine-protein kinase PrkC (Ser/Thr-protein kinase PrkC) (EC 2.7.11.1) (A6QGC0)
Organism: Staphylococcus aureus (strain Newman)
Function: Probable protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing either m-Dpm (meso-diaminopimelate) or L-lys, which act as spore germinants. Probably autophosphorylates and phosphorylates FusA (EF-G, elongation factor G); the latter modification is likely necessary for germination in response to peptidoglycan.
Subcellular location: Spore membrane; Single-pass type II membrane protein. Note=Is associated with the inner membrane of the spore. {ECO:0000250}.
Interaction partners:
Sequence:
MIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSNVILRATEKDKANRYKTIQEMKDDLSSVLHENRANEDVYELDKMKTIAVPLKKEDLAKHISEHKSNQPKRETTQVPIVNGPAHHQQFQKPEGTVYEPKPKKKSTRKIVLLSLIFSLLMIALVSFVAMAMFGNKYEETPDVIGKSVKEAEQIFNKNNLKLGKISRSYSDKYPENEIIKTTPNTGERVERGDSVDVVISKGPEKVKMPNVIGLPKEEALQKLKSLGLKDVTIEKVYNNQAPKGYIANQSVTANTEIAIHDSNIKLYESLGIKQVYVEDFEHKSFSKAKKALEEKGFKVESKEEYSDDIDEGDVISQSPKGKSVDEGSTISFVVSKGKKSDSSDVKTTTESVDVPYTGKNDKSQKVKVYIKDKDNDGSTEKGSFDITSDQRIDIPLRIEKGKTASYIVKVDGKTVAEKEVSYDDV
Protein: SEC-C motif-containing protein (Q9XWH5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNDTEYTAHILARTIRTGDDKLITKAFSQLKFGTVPMDILEQHNFPYIVQRHAPNNQLALSMASNYQNFKLQKIEHEKPWMLKRFADSTFEEYPDGIVSVHTLKLLTAVSFFTDLDFVKCSFSILSRLDLLVEDFEKYGILERAKVFEHQIQEAAWLVRKYQRLKDEVESEVEEESEETEVAPSLDRRYPPIHGDFTHNRMEIEMIFLAQCIKAGNEEMISTAIEFVGTDELPLEFYRKYDIALSCHLYCPEQEDCKHLIDFIEEMEEVGMQWENLEALERYLRENSELGLVPDSVMTLLMGYFKGDRYLGDEDWKDYFVDPICNFFLSQDVSLDQFERFDVKNILVKFEERATKPVKLVLQKIEDLKSA
Protein: Phosphate regulating endopeptidase X-linked (A0A8I6ALX7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MEAEAGSTMETGKGTNRGIRIALALFITGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW
Protein: Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) (Q9UFC0)
Organism: Homo sapiens (Human)
Function: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Subcellular location: Nucleus {ECO:0000269|PubMed:18445686}. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8BUI3}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Interaction partners:
- Origin recognition complex subunit 3
- Origin recognition complex subunit 5
- Origin recognition complex subunit 2
- Origin recognition complex subunit 4
- Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- DNA-binding protein REPIN1
- DNA replication factor Cdt1
Sequence:
MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLRKVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYGPESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKRRVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPTQILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM
Protein: Protein kinase A regulatory subunit (Q9GU80)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSEKGTSLNLFLAACQKEGVKQPNTFLVEFFTKKPELSEVEEIDLSKNYIGNRGILALLDVISELPCFRFLNCSNQKLYNTDLNEDSVRGNATIDRIVDVFKSHPTANALDLSHNPISNYAGRRLLLLTQNNKRICRVELVDTRIDFELRSRITQQCEKNTIAIWESQAQEKEEERAFGESVTWVPTQTSADLTAIGGGRKRRTTVRGEGIDPEKAKSYVAPYFEKSEDETALILKLLTYNVLFSFLDSRDLMTVAGAMWRVEFKQDDCIMEAGQTTCDKLYIIQDGKADIIKEGQKVYLKVEGTAVGELELMYQTPTVATVKVCTPELIAWALDRDTYRHLVMGSAIRRRETYIQFLTNIPFLSGLDNYEKLQLADALSSDEFEPGDYIIRYGEEGEWLYIILEGSVDVVGRDDDGNEKHVWEFGKGDHVGELEFLNNHANVADVVAKTHVVTAKLNRRHFEMCLGPVIDVLKRTSQQPNYEYYQSKLKTTLRAEGRK
Protein: Na/Ca-exchange protein, isoform F (A0A0B4K6A6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQLLLKSIFTCALFVIFVYATAQSLLKVQETEARQAYLNVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAPDAEELRECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIRV
Protein: Sll0359 protein (P74426)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Slr2144 protein
- Slr0613 protein
- NAD
- Sll1926 protein
- Ssr2551 protein
- Slr1302 protein
- Sll0372 protein
- Thylakoid membrane protein slr1949
- Ycf51-like protein
- Ssr0332 protein
Sequence:
MLYFILCRLLKKTSPRNQASFNGKNNPMPNASTALTGKALLNKVKELSHLPRRETAKACGYYSTSKEGQVRVNLTDFYDAVLAAKGVPLDPSGTKDGRGREPTFRVSVHKNGQIVIGSTYTQEMGLKSGDEFEIKLGYKHIHLKQITDSDDEEEV
Protein: T-complex protein 1 subunit alpha (CCT-alpha) (Q381B0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit eta
- T-complex protein 1, zeta subunit, putative
- T-complex protein 1 subunit gamma
- CCT-beta
- T-complex protein 1 subunit delta
- CCT-theta
- GST N-terminal domain-containing protein
- 10 kDa heat shock protein, putative
- Phosducin domain-containing protein
Sequence:
MLVDDVGDVCVTNDGATILKSLDVEHPAARLLVDLAQLQDKEVGDGTTSVVILAAELLKRAQDLIVQGIHATSIIAGYKLALREALRYLKDSLSVSVNALGKEVLLNIARTSMSSKILSADAELFAKIVVDAIQSVKTVNDLGDVVYPRKAVSILLQHGKSSRESMLLQGFALGLSRAAQGMPTSVQNAKIALIDFDLRAVKMKLSMNITITDPTKAEAIRQRELDITKERIKKMIAAGANVILTSWGIEDSMMKYMVDEGILGVRRVKKEDMRRIAKATGAQIVHTMSDLEGEEVFESKWLGQADRVYEERFGEDDVIIISGTSNSVCATIVCRGANYFVLEEMERALNDALWAVARTLEASLVVAGGGAVEAALSVYLENFAFTLGSREQLAVAAFAEALLVIPKTLALNAAMDATELVSRLRVIHNEAQREGAKGGNAGSASRFCGLDLVEGTARNNVEAGVLEPQPSKVKSLQFATEAAITIIRIDDCVRLNPEEEEEGRR
Protein: Phosphatidylinositol 4-phosphate 5-kinase 59B, isoform H (EC 2.7.1.68) (A0A0B4K7M0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASGDGDTINTIDMDSSSASQAKLAEPSNASTDHVGNSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVPPGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIHDGETVSVCRPSFYAQRFQNFMAKTVFRKIPSPLKHSPSKRKSLSKAIQRSIDSDNEVASRPVHASHSHSSGKIHQPAKPPTTEPTPAGAAGGAERGATALGPATTSGASERAPPPVKQRTPAASNLKTRVPPPVPPRGSPRRKDAQDRTTPGTTPSCSSTPPPAFDDISEDSSNKNSSSSIGRRSHHHHHHHQQSQQHQQSYYLDRKMNIGPAYRGSYKEDIVSVSEVHLDTLLAVDTSSSSQYGSRGGLAWTPPASGEGSTPTWTEGTPSFTDSSSSGDLDNFSPINSSKIDRHKPTVEEAINSLSAGMIN
Protein: Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) (A1XQX0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSFSMRNGAHLIWIGLLVCCLVDMGASMEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVYFDDEGFCDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIPPELRSVALRLTSSAIKDEVPYKGWITNLRVNGSEPVLIGSDGVNSDICEADHICLNGGVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAVGVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVADPVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKIDTKITTQTTMGAKNLDLKGDLYVGGVAKDMYKDLPKLVHSKEGFQGCLASVDLNGRLPDLQSDALSTAGQVERGCEGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQQKDAVLVRVDSSSGLGDYLQLQIERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSRPFQGQLSGLYYNGLKVLNMAAEGDPNVRVEGSARLVGDMPSSSITPQSSVSAAGNRSETSPSITDITTTTASNRQGKQTTTPQDDLLVASAECPSDDEDIDPCDPSSGGLAHPPLPEAKGYPSPEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSATQPNGAAVKEKPIGVPKNKKDKKNKDKEYYV
Protein: Xyloglucan galactosyltransferase XLT2 (EC 2.4.1.-) (Glycosyltransferase 18) (AtGT18) (Protein XYLOGLUCAN L-SIDE CHAIN GALACTOSYLTRANSFERASE POSITION 2) (F4K6F1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions in xyloglucan synthesis by adding side chains to the xylosylated glucan backbone. Involved in galactosylating hemicellulose xyloglucan (XyG) at the second position of the XXXG motif to form XLXG. Associates with other xyloglucan-synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:22474179, ECO:0000269|PubMed:25392066}; Single-pass type II membrane protein {ECO:0000305|PubMed:25392066}.
Interaction partners:
- Xyloglucan glycosyltransferase 4
- Xyloglucan 6-xylosyltransferase 2
- Xyloglucan 6-xylosyltransferase 1
- Galactoside 2-alpha-L-fucosyltransferase
- Probable beta-1,4-xylosyltransferase IRX10
- Probable xyloglucan 6-xylosyltransferase 5
- Probable xyloglucan glycosyltransferase 5
- Polygalacturonate 4-alpha-galacturonosyltransferase
- Protein kinase superfamily protein
- Probable xyloglucan glycosyltransferase 6
Sequence:
MLPVSNPSSPEHLLKKSRTPDSTTSIDRKNSFNSLHSVGNRSSYIAASRSHCTWLILSLLSLQLILFLTLRSIPFPHRHIPENFPSPAAVVTTTVTTTVISAASSNPPLSSSSSDERCDSGRVFVYDMPKIFNEVILQQCDNLNPWSSRCDALSNDGFGQEATSLSNVIPKDLVQSWFWTDQFVTEIIFHNRILNHRCRTLDPESATAFYIPFYAGLAVGQYLWSNYAAADRDRHCKMMTQWVKNQPYWNRSNGWDHFITMGRITWDFRRSKDEDWGSNCIYIPGMRNITRLLIERNSWDHFDVGVPYPTGFHPRSDSDVVNWQDFVRNRRRETLFCFAGAPRAGIVNDFRGLLLRHCEESRGKCRTVDCTVGKCSNGSSAILETFLGSDFCLQPRGDSFTRRSIFDCMLAGSIPVFFWRRSAYMQYQWFLPDKPDSYSVFIDRNEVTNGTTSIKEVLERYSKEDVRKMRERVIDLIPNLVYAKSPNGLETFKDAFDVAIDGVFRRFKEQEKWYKWR
Protein: Afamin (Alpha-albumin) (G3MYZ3)
Organism: Bos taurus (Bovine)
Function: Functions as carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P43652}.
Interaction partners:
- Histidine-rich glycoprotein
- Serum amyloid P-component
- Beta-2-glycoprotein 1
Sequence:
MKQLKLTGFVIFFFFLTESLTLPTQPQDVDDVRITQKFIDDNIGYITIIAFAQYIQEASFEEVEMLVKAMTEYRDKCLADRTLPECSKLANEVLLENICAMEGLPQKYNFSHCCHKVDFERRLCFFHNKKADIGLLPPLPTLDPEEKCQTYKNNRESFLNNYVYEVSRRNPFVFAPTLLTVAARFEEMTKTCCEEQEKANCFQTKAEPFIYYLKALSSYQKNACRALMKFGRQILQSINIAILSQKFPKIGFKQLTSLLEDVSSKYDGCCEGDVVQCIRGRSKVMSHICSKQDSISSKIKDCCEKKIPERGECIIYSNKDDRPNDLSLREAKFIESDNVCEKRDADQANFMAEFLYEYSRRHPELSTPELLRIAKVYKDLLKECCNMENPPECYRHAENRFNETTEKSLKIVQRECEHFQNLGKDDLKYHYLINLTKLAPQLSTEELTFLGKEMVMALTTCCTLSEEFACVDNLVDLVLGELCGINENRNINPAVDHCCKTNFAFRRSCFESLEADKTYVPPSTSQGLFTFHADLCQAHNEELQRKKDRFLVNLVKLKPELAGEELWSLLADFTNVVEKCCKAQEPEACFKEESPKLAAKSQAA
Protein: Small ribosomal subunit protein uS12cz/uS12cy (30S ribosomal protein S12, chloroplastic) (P0C461)
Organism: Oryza sativa subsp. indica (Rice)
Function: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity).
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Uncharacterized protein
- Small ribosomal subunit protein uS2c
- Small ribosomal subunit protein uS7cz/uS7cy
- S5 DRBM domain-containing protein
- Uncharacterized protein
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein uS7c
- Small ribosomal subunit protein bS16c
- Uncharacterized protein
Sequence:
MPTVKQLIRNARQPIRNARKSAALKGCPQRRGTCARVYTINPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYRIIRGALDAVAVKNRQQGRSKYGVKKPKK
Protein: Cytochrome P450 2C38 (EC 1.14.14.1) (CYPIIC38) (P56655)
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase that primarily catalyzes the epoxidation of 11,12 double bond of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 11,12-epoxyeicosatrienoic acid (11,12-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 3A11
- Cytochrome P450 1A2
- Cytochrome P450 2C50
- Cytochrome P450 3A25
- Epoxide hydrolase 1
- Cytochrome P450 2E1
- Cytochrome P450 2U1
- UDP-glucuronosyltransferase 2A3
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Arachidonate 12-lipoxygenase, 12R-type
Sequence:
MDLVTFLVLTLSSLILLSLWRQRSRRGRLPPGPTPFPIIGNFLQIDVKNFNQSLTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPMSEKINNGLGITFSNGNSWKETRRFTLMTLRNLGMGKRNIEDRVREEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNFKYIRSYLLEKVKEHQESLDVTNPRDFIDYFLIKQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRHRSPCMQDRSRMPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSAGKRVCAGEGLARMELFLILTTILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCFIPL
Protein: Putative F-box protein At5g39460 (Q9FLZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMNKESFGACLLLTLPEDVFAVISRFLSPSDICNLILCGKSLCALVDSEKTWLVQCEEVKVLPLIELVQWRIGISSYKALCRFLVEVVKPLLGIWVQENPELGNVVYVMPGFLSVVGCRIIPQKVAPLWIQEGQVKWSPVFEIICGFDGSKGFFLHGRDKQGSFLYPGFVMDIEKSCNVLLLEVEPRSEKSSCNEIEREVGDPFGDLDFSDRMNLLDIVTKHVSLRVDEPLTGNLFPTRSKYDEAMMLERRNMLLKMLKFGGNWKHINLEEDEQLCYNHIEIDIKKLLENLGDDIDNMEDIEDQIEVTPRKKSFRRFLRSGIKHILGKFSSSKINSPSSSETRRSNRQSFLSSGNTFCLSLKASCTLMSSYEGWPIMSADNFSLHKLPMKKPLDHDVYAGLWGGTFGWPPGKDIEDESLLLLMLTYGESEEGSERILFGTKILSYFAEHPNGSSMFVVNIDTPSLEPFPFDTDGRDFEHSYTGEGIADGYGFRYPGSKPGSLFVSSNDLLAFVWQGTEDVITLQRINLGEILKKSLGSCVSPLLPTKNFTYTKRSYSNVFAKSSTYSSSSE
Protein: MutL homolog 3 (A0A1Y7VMP7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MIRCLSDDVKTKLRSGLAISSLGQCVEELTLNSIDAEATCVAIRVNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPAFYGFRGEALASIADMAGAVEISSKKNTTLKTFVKMFQNGKALATHEADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMVLQLPKTKDICSRFCQIYGLGKSQKLREIRFKYKEFEFSGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQSWDTVLICIQEGVKRFLKQEKLFVELSGEDIKEFNEDNGFSLFGTTLQTHVSTHEKCDQSSFREACNKILDSYEMFNLQSKAVKRIATLENKTRQNPGDSETIRKKTVGSLYTDASDGPCYSKSVESVLQDSNNSAYLEPRVSEEEVAKTSHSGENEKWKKSFLENKTSGRIHETSPKMFSSPIQMHHLLEEREADLEMQTISSTVNVMAANIPQNNDIPSQLEKWKDAPEVGCQPLPFETTLLRVRGTQRKKERRKKEPSSRGRVNVFSYGQVKLCSTGFITHVVQSEHAKSTETEHSFKNYARPGPVSAQETFGKRTHHAIETPDSSDLTSTLSKESSQPPNKRFCRTNTGYGTENKPVATDDNLALFQESCKESHTDRLLPDASSFPWCRYVSDGCRKIDKRGSFKQVVRRKLSLRSQVGSLEKFKRQYGKVSSSLDTEKDNNTEVRTHLDPQNEPDVLLKDKSHLDMSDGCEITTVEHSETCQPLSPILYPEKILFSKEDRLEQMPHLRESPITLEELSHCNRKADVEKSAASLASKLSKLKDSEKEMQTVGMTGHTSELPDSNPSWKDNSQCTRLDLDFCELLKNKLEKIESDMLPMADSATEDGPINKNSELHPNNTTDDTEKPETPLLFPCNDSKISRDSDVLIRTSEQPTGNPDSVGKVIMSQVEDGIGSQGGVCPQGDESKARSCSKNEPNAHCMDWQQHFDVTLGRMVYINRMTGLSTFVAPTDDLHTACTKDLTTVAVDVLLGNGAQYRCHPFRSDLVLPFLPRAQEERTMLRHNSNAVDAAAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAESLAVKIHNVLYPYRFTKEMIHSVKVLQQVDNKFIACLMSTRMDEDGRTGGNLLVLVDQHAAHERIRLEQLITDSYEKQDPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRSYHKHLEDLGLELLFPDASDSLILVGKVPLCFVEREASELRRGRSTVTKSIVEELIREQVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADLDHLEQEKQVKPNLAKLRKMVRAWHLFGKTEQNLQQPIRPCEPP
Protein: 39 protein (Glycoprotein M) (O41956)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Interaction partners:
Sequence:
MPALKVPQLKKLEPSRSDSFLLKSWTNLLALLTLLFVTSSTVPILASFRGVGFPCYFVNLVDYSTLNLTVRNSAKHLTPTLFLEGPEMFVYIVWSFLTEAINIIYFIFGAVTVYRLKKIFMPSLNAIQVWLTLIGGHSTLYLSIARLWTLQLFVHVLSFKQIFLAAFVYLFHFMLSYVHVHVFISRYVPQWQANDMEQKIPEGSSLEKLVLFYRPILANIQMSLLALEMLVFSLSVMMAVCNSFYILVSDAVFGAVNLFLIISLVWHIGAEVFLAKYLRHHVGFYIGLFVAYVIMLLPVIRYDAIFVTSRLHKPITINMTIIPIICLIIIVVRIIRLRSQTSTKVTYKKLGISGAMEAQPFQSIPQPPRAKYTDLETESEDEL
Protein: Alpha/beta-Hydrolases superfamily protein (Putative esterase) (Q9ZUN7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKPTKIVIPNRRNEKLVGLLHETGSKEVVVLCHGFRSDKTNKILKNVATALEKEKISSFRFDFSGNGDSEGTFYYGNFNSEAEDDLHYVIQHLSSSNIMNRLVPVILGHSKGGDVVLLYASKFPDYIRNVVNISGRFDLKNDVRLGDGYIEKIKEQGFIDATEGKSCFRVTQESLMDRLNTDMHQACLNIDKQCKVLTVHGSDDTVVPGEDAKEFAKVIPNHKLEIVEGANHGYTKHQKELVSIAVEFTKTAIVEQHNLLVVFGRWLIIVMIVVTFYMSVFDHLIKVYPLLVIFKLENVMSRIQQLIYLIFFYLLRIKLLLGLWLLLLERRM
Protein: LDL receptor repeat-containing protein egg-1 (A8X765)
Organism: Caenorhabditis briggsae
Function: Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatases egg-3, and possibly egg-4 and egg-5 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q09967}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q09967}. Note=Localizes to the cell membrane of developing oocytes. Plasma membrane localization requires extracellular matrix protein cbd-1. After fertilization, localizes to endosomes in zygotes. {ECO:0000250|UniProtKB:Q09967}.
Interaction partners:
- Protein CBR-EGG-4
- Protein CBR-EGG-3
- chitin synthase
- Protein CBR-SPE-9
- Protein CBR-PERM-4
Sequence:
MSSIAQKNRNYFLYIFYGRIFNSSDKTFFIIKKQLVIAPNFFSVDQKLICSSELFCGTACSRSLVVLYENYKKIVILNSPQFFAGLDSGRENQSPDGSVQGNGLKWMLFLCQKSKRTIFSNHSNLFQCPSVAIVLVLALVILGVLAAIPLTLMLTSSAQKMSTDSTDLTDYSIRHPKFWPKTDKIHFDDLGGIPMSSMFPPNVSTCSGFGFACTGAVHMVIPSSKRCDGFKDCQDGSDEENCKECQSVFSCRSHIEEDSKKKRKTKVQPTLICLTAERLCNGVQDCLDGSDEAMCKSTCSKDQFKCNGSNACLPLSAKCDGVKDCSDGSDENNCNKCQKGAHVSLVSRNIKHLFASHVCDGVAQCADRSDEQQCDCKTCSGSDKALCDDGTCIKRSQVCDGKKDCSDGMDEENCPGTCSIEAFATKVKRVTCSDGKDYTESEACSGVEESCGGSCSKCHPKLTFTCPAAGNAQKKCIKRSKVCDGIFDCDDGADEKNCTPVKECGIDNASQFTCDRKCVDASRRCDGVWDCEDKSDEQNCSQCASGSIKCSADKKCLPAYTRCNGVAECSDGSDELKCSCEECLGAHSNTYMCSESNRCLKRDEVCSPYSMCPNATYTDKAYCAALVLKNSGRFPY
Protein: Thyrotroph embryonic factor (Q10587)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
Subcellular location: Nucleus.
Interaction partners:
- Pyridoxal kinase
- Period circadian protein homolog 3
- Nuclear receptor subfamily 1 group D member 2
- Period circadian protein homolog 2
- Nuclear receptor subfamily 1 group D member 1
- Thyrotropin subunit beta
- Basic helix-loop-helix ARNT-like protein 1
- Cryptochrome-2
- Cryptochrome-1
Sequence:
MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
Protein: RNA exonuclease 2 (H0YG54)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQAEYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWYPEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS