wanglab/gogpt-training-data huggingface dataset:
Protein: Granulin precursor (K7EKL3)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
XAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQVSANPHPGAGYGQGPGPTSSNPLAPL
Protein: Secernin-1 (Q6AY84)
Organism: Rattus norvegicus (Rat)
Function: Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Vesicle-associated membrane protein-associated protein A
Sequence:
MSGAPPSYSFVALPPRAKDGLVVFGKNSARPRDEVQEVVYFPAVDHEAESKVECTYISIDQVPRTHAIVISRPAWLWGAEMGANEHGVCIANEAINAREPAAETEALLGMDLVRLGLERGTTAKEALDIIVSLLDEHGQGGNYYEDAHSCHSFQSAYLLVDRDEAWVLETVGKYWAAERITEGVRCICNHLSLTTKMDEEHPELRTYAQSQGWWTGEDEFNFAQVFSPADDHLDCCAGKDSLEKQEESITVQTMINILRDKASGVCIDSESFLTTASIVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKAQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAVIESDQEQGRTLRKTMLELEKQGLEAMEEILSSPEPPDPAEVGDLFYDCVDTEMKFFK
Protein: Propionyl-CoA carboxylase, beta subunit (EC 6.4.1.3) (Q5LUG0)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Interaction partners:
- Propionyl-CoA carboxylase alpha chain
- methylmalonyl-CoA epimerase
- Biotin carboxylase
- Carbamoyl-phosphate synthase, putative
- Acetyl-CoA carboxylase, biotin carboxylase, putative
- MaoC family protein/phosphate acetyl/butaryl transferase
- Propionate--CoA ligase
- Acetyl-coenzyme A synthetase
- Acetyl-coenzyme A synthetase
- L-malyl-CoA/beta-methylmalyl-CoA lyase
Sequence:
MKDILSELETRREAARLGGGQKRIDAQHARGKLTARERIELLLDEDSFEEFDMFVSHRCTDFGMEKQRPAGDGVVTGWGTINGRMVYVFSQDFTVFGGSLSETHAQKICKIMDMAVQNGAPVIGINDSGGARIQEGVASLAGYAEVFQRNIMASGVVPQISVIMGPCAGGAVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNEVVTAEELGGASTHTRKSSVADGAFENDVEALAEVRRLVDFLPLNNREKPPVRPFFDEPGRIEASLDTLVPENANTPYDMKELINKIADEGDFYEIQEDFAKNIITGFIRLEGQTVGVVANQPMILAGCLDIDSSRKAARFVRFCDCFEIPILTLVDVPGFLPGTSQEYGGVIKHGAKLLFAYGEATVPKVTVITRKAYGGAYDVMASKHLRGDFNYAWPTAEIAVMGAKGATEIIHRADLGDADKIAAHTKDYEGRFANPFVAAERGFIDEVIQPRSTRKRVSRAFASLRGKSLKNPWKKHDNIPL
Protein: U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) (Q42404)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:18414657}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18414657}. Note=The exchange between speckles and nucleoplasm is sensitive to ongoing transcription and phosphorylation. {ECO:0000269|PubMed:18414657}.
Interaction partners:
- U1 small nuclear ribonucleoprotein C
- Serine/arginine-rich splicing factor RS2Z33
- Serine/arginine-rich-splicing factor SR34
- Serine/arginine-rich splicing factor SR45
- Probable small nuclear ribonucleoprotein G
- Nuclear protein-like
- U1 small nuclear ribonucleoprotein A
- Small nuclear ribonucleoprotein SmD3a
- Small nuclear ribonucleoprotein Sm D2
- U2 small nuclear ribonucleoprotein A'
Sequence:
MGDSGDPFLRNPNAAVQARAKVQNRANVLQLKLMGQSHPTGLTNNLLKLFEPRPPLEYKPPPEKRKCPPYTGMAQFVSNFAEPGDPEYAPPKPEVELPSQKRERIHKLRLEKGVEKAAEDLKKYDPNNDPNATGDPYKTLFVSRLNYESSESKIKREFESYGPIKRVHLVTDQLTNKPKGYAFIEYMHTRDMKAAYKQADGQKIDGRRVLVDVERGRTVPNWRPRRLGGGLGTSRVGGGEEIVGEQQPQGRTSQSEEPSRPREEREKSREKGKERERSRELSHEQPRERSRDRPREDKHHRDRDQGGRDRDRDSRRDRDRTRDRGDRDRRDRDRGRDRTSRDHDRDRSRKKERDYEGGEYEHEGGGRSRERDAEYRGEPEETRGYYEDDQGDTDRYSHRYDKMEEDDFRYEREYKRSKRSESREYVR
Protein: LINE-1 retrotransposable element ORF2 protein (ORF2p) (Long interspersed element-1) (L1) (Retrovirus-related Pol polyprotein LINE-1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] (P11369)
Organism: Mus musculus (Mouse)
Function: Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome. Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition. Does not bend the DNA helix unlike related endonucleases but causes compression near the cleavage site.
Interaction partners:
- Ubiquitin-like protein FUBI
Sequence:
MPTLTTKIKGSNNYFSLISLNINGLNSPIKRHRLTDWLHKQDPTFCCLQETHLREKDRHYLRVKGWKTIFQANGLKKQAGVAILISDKIDFQPKVIKKDKEGHFILIKGKILQEELSILNIYAPNARAATFIRDTLVKLKAYIAPHTIIVGDFNTPLSSKDRSWKQKLNRDTVKLTEVMKQMDLTDIYRTFYPKTKGYTFFSAPHGTFSKIDHIIGHKTGLNRYKNIEIVPCILSDHHGLRLIFNNNINNGKPTFTWKLNNTLLNDTLVKEGIKKEIKDFLEFNENEATTYPNLWDTMKAFLRGKLIALSASKKKRETAHTSSLTTHLKALEKKEANSPKRSRRQEIIKLRGEINQVETRRTIQRINQTRSWFFEKINKIDKPLARLTKGHRDKILINKIRNEKGDITTDPEEIQNTIRSFYKRLYSTKLENLDEMDKFLDRYQVPKLNQDQVDHLNSPISPKEIEAVINSLPTKKSPGPDGFSAEFYQTFKEDLIPILHKLFHKIEVEGTLPNSFYEATITLIPKPQKDPTKIENFRPISLMNIDAKILNKILANRIQEHIKAIIHPDQVGFIPGMQGWFNIRKSINVIHYINKLKDKNHMIISLDAEKAFDKIQHPFMIKVLERSGIQGPYLNMIKAIYSKPVANIKVNGEKLEAIPLKSGTRQGCPLSPYLFNIVLEVLARAIRQQKEIKGIQIGKEEVKISLLADDMIVYISDPKNSTRELLNLINSFGEVVGYKINSNKSMAFLYTKNKQAEKEIRETTPFSIVTNNIKYLGVTLTKEVKDLYDKNFKSLKKEIKEDLRRWKDLPCSWIGRINIVKMAILPKAIYRFNAIPIKIPTQFFNELEGAICKFVWNNKKPRIAKSLLKDKRTSGGITMPDLKLYYRAIVIKTAWYWYRDRQVDQWNRIEDPEMNPHTYGHLIFDKGAKTIQWKKDSIFNNWCWHNWLLSCRRMRIDPYLSPCTKVKSKWIKELHIKPETLKLIEEKVGKSLEDMGTGEKFLNRTAMACAVRSRIDKWDLMKLQSFCKAKDTVNKTKRPPTDWERIFTYPKSDRGLISNIYKELKKVDFRKSNNPIKKWGSELNKEFSPEEYRMAEKHLKKCSTSLIIREMQIKTTLRFHLTPVRMAKIKNSGDSRCWRGCGERGTLLHCWWECRLVQPLWKSVWRFLRKLDIVLPEDPAIPLLGIYPEDAPTGKKDTCSTMFIAALFIIARSWKEPRCPSTEEWIQKMWYIYTMEYYSAIKKNEFMKFLAKWMDLEGIILSEVTHSQRNSHNMYSLISGY
Protein: UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase (EC 2.4.1.304) (B5L3X1)
Organism: Shigella boydii
Function: Galactosyltransferase that adds one galactose residue in the beta-1-4 linkage to GlcNAc-alpha-pyrophosphate-lipid in the biosynthesis of the O-polysaccharide repeating unit of the O antigen.
Interaction partners:
Sequence:
MIDNLIKRTPEINRLLENKRVTGVVTFVNPYSYYKIKEYNKISQLDYIYIDGILLLKLFNFVNGTKIKRHSFDYSSIAKTVFNYSIQNKMKIGLIGSKDYEIEQAVKNIRKKHPGIDISYFHSGYFSSLEEKSSVIDSVIKKSDIIICGLGTPAQEELALDIKIKSNEHLIFTCGGFFTQTASRADFYYPWIKRYNLMWLQRIVLYKHVRKRFFIDYPKFIVRFISENLMKIFTRSN
Protein: Ig-like domain-containing protein (Q38BM7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
Sequence:
MRGDVPLPVWQLKVINGCICNNDLILPTSPQPLLLEHFYNSWSEDSGSARVKKNRIPRRVGRGSVCNTKASSGLAGVQTDEWMKTIPHVVLGRHTLLPSDYRLKHGSISRLQCRVVHVENTVFHRKVLSKFPPMTWGVPSGTNSGRSTTGYKCGDNGTTKFEGPYFCLLNSGSNPLYVNDRQLPQGRSHCLCENDIISFLENPFDEEGGILQPLRPEDNVNSGATGQSGLTYGVHVANGDESKYLSYNHTAPQRSNGSPGCSTASFPECGTTIPSFVEVGGKRIARYRESVAPRRLPQPLDSVSAGVCQNVDGGLSGLSPPKTNNALSSLEEGKDCKLEQDEPKYLSEVYTKTPTKGIDVRETPVVVCHDYDEDITPPKVFNCDGRFPYEMTGHSASAIVDDTISPVRPRVITRGNRNDNIPTEVEEPCVVLPPQLPVYVFSRRSPSPVGLTCRTQFVEPIKVSNGLQREGRRSVQSSVKLDAGAKKGKAISGKSSLTVPRPRKRNRW
Protein: S-adenosylmethionine-dependent methyltransferase Rv2258c (EC 2.1.1.-) (O53532)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probable methyltransferase that may target bulky nonpolar molecules with aromatic rings.
Interaction partners:
- Conserved protein
- Small ribosomal subunit protein uS2
- S-nitrosomycothiol reductase MscR
- Metallo-beta-lactamase domain-containing protein
Sequence:
MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK
Protein: At1g77930 (Chaperone DnaJ-domain superfamily protein) (F28K19.14) (Q9SH08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Chaperone DnaJ-domain superfamily protein
- Cytochrome b-c1 complex subunit 8-1, mitochondrial
- NAD
- Chaperone protein dnaJ C76, chloroplastic
- At3g13310
- TonB-dependent heme receptor A
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- At2g42750/F7D19.25
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Serine/threonine-protein kinase STN7, chloroplastic
Sequence:
MSNLRAICRPYSVFSSIVCCSRHQSRSLFRVSIKNVAFRNQSSNSSWFRSKNSNLWFRLNQRKTLVRASNWSQEKSPYDTLELDRNAEEEQIKVAYRRLAKFYHPDVYDGKGTLEEGETAEARFIKIQAAYELLMDSEKKVQYDMDNRVNPMKASQAWMEWLMKKRKAFDQRGDMAVAAWAEQQQLDINLRARRLSRSKVDPEEERKILEKEKKASRELFNSTLKRHTLVLKKRDLMRKKAEEDKKKLITQLLAAEGLELDTEAEEEEAAK
Protein: Transmembrane protein 25 (Q86YD3)
Organism: Homo sapiens (Human)
Function: In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q9DCF1}. Lysosome {ECO:0000250|UniProtKB:Q9DCF1}.
Interaction partners:
Sequence:
MALPPGPAALRHTLLLLPALLSSGWGELEPQIDGQTWAERALRENERHAFTCRVAGGPGTPRLAWYLDGQLQEASTSRLLSVGGEAFSGGTSTFTVTAHRAQHELNCSLQDPRSGRSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTSASLPAPGLLATRVEVPLLGIVVAAGLALGTLVGFSTLVACLVCRKEKKTKGPSRHPSLISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDSRAVKPADRQMAQNNSRPELLDPEPGGLLTSQGFIRLPVLGYIYRVSSVSSDEIWL
Protein: GEN1 Holliday junction resolvase homolog (Q22418)
Organism: Caenorhabditis elegans
Interaction partners:
- Crossover junction endonuclease MUS81
- Structure-specific endonuclease subunit SLX1 homolog
- DNA repair endonuclease XPF
- RecQ-like DNA helicase blm-1
- ERCC1-like central domain-containing protein
- SAP domain-containing protein
- DNA replication ATP-dependent helicase/nuclease DNA2
- DNA repair protein RAD51 homolog
- Regulator of telomere elongation helicase 1 homolog
- BSD domain-containing protein
Sequence:
MTINGIWEWANHVVRKVPNETMRDKTLSIDGHIWLYESLKGCEAHHQQTPNSYLVTFFTRIQRLLELKIIPIVVFDNINASSSAHESKDQNEFVPRKRRSFGDSPFTNLVDHVYKTNALLTELGIKVIIAPGDGEAQCARLEDLGVTSGCITTDFDYFLFGGKNLYRFDFTAGTSSTACLHDIMHLSLGRMFMEKKVSRPHLISTAILLGCDYFQRGVQNIGIVSVFDILGEFGDDGNEEIDPHVILDRFASYVREEIPARSEDTQRKLRLRRKKYNFPVGFPNCDAVHNAITMYLRPPVSSEIPKIIPRAANFQQVAEIMMKECGWPATRTQKELALSIRRKVHLTTTVAQTRIPDFFAATKSKNFTPIVEPCESLEDYISANNTWMRKRKRSESPQILQHHAKRQVPDRKRSVKIRAFKPYPTDVIELGDSD
Protein: Exosome complex component RRP46 (Exosome component 5) (Ribosomal RNA-processing protein 46) (Q9CRA8)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NQT4}. Cytoplasm {ECO:0000250|UniProtKB:Q9NQT4}. Nucleus {ECO:0000250|UniProtKB:Q9NQT4}.
Interaction partners:
- Exosome complex component 10
- Exosome complex component RRP4
- Exosome complex component MTR3
- Exosome complex component CSL4
- Exosome complex component RRP40
- Exosome complex exonuclease RRP42
- Exosome complex component RRP41
- Exosome complex component RRP45
- Exosome complex component RRP43
- Nuclear nucleic acid-binding protein C1D
Sequence:
MEGAKRADANLLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLVRNTCEAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVTCALDSDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSTTKGLYSDAELQQCLAAAQAASQHIFRFYRESLQRRYSKS
Protein: Ras-related protein Rab-4B (EC 3.6.5.2) (P61018)
Organism: Homo sapiens (Human)
Function: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:20534812}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rab GDP dissociation inhibitor alpha
Sequence:
MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC
Protein: ShKT domain-containing protein (Q9GZE5)
Organism: Caenorhabditis elegans
Interaction partners:
- CUB-like domain-containing protein
- CUB-like domain-containing protein
- C-type lectin domain-containing protein
- IgGFc-binding protein-like
- Uncharacterized protein
- CUB_2 domain-containing protein
Sequence:
MKLLLLIFVPFVTCGLTCMDFMIDCPRIVYYCDETYVQNQCQFSCGICKQDPGVCGDTYFDCDMYDTKCNSPSFQRQCAGTCGLCPGACEDIWDGCSHFLAPCSDDIKSLCPIKCGLCNSTTTPMILTTITPVDPRCVDAGNQCANYSPPCSDDVKIFCPATCGSCSNGTTGVPLVLTTLTPELTTVTVEPITSTLKPTTTTITPTTTTKLPTTTTKKLPPTTPKPPCKDSSPNCAGWAKNGFCTNTFYPPEKRKEYCGKTCRMC
Protein: Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) (Q9UKD1)
Organism: Homo sapiens (Human)
Function: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Subcellular location: Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Interaction partners:
- Glucocorticoid modulatory element-binding protein 1
- Peregrin
Sequence:
MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAAAAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDPGDWTAAIGDDTFTFWRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVSLPPPVKRPRLARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPLGKVVSTLPSTVLGKGSLQAPPASSPASPLLGGYTVLASSGSTYPSTVEIHPDASSLTVLSTAAVQDGSTVFKVVSPLQLLTLPGLGPTLQNVAQASPGSSTIVTVPAGAAPGPEEHTATIEVAAMAEDHERK
Protein: Cytochrome c oxidase subunit IX (Q38AD2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit 8, putative
Sequence:
MFSCALRTSRRTYINAFNAKAKARPNFGLRGVGYWTSEVYHKPGQNYWTLLCTTGPFLVIGSIMYDGFWAKLDDIAGGGPSHLDYGWRKQDRKPWDFAFDIGEGYAAGPATLRPAPGAVDLGHH
Protein: Effector protein HopAB2 (Avirulence protein AvrPtoB) [Includes: E3 ubiquitin-protein ligase (EC 2.3.2.-) (E3 ubiquitin-protein transferase)] (Q8RSY1)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Function: Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.
Subcellular location: Secreted {ECO:0000269|PubMed:12062102}. Note=Secreted via type III secretion system (T3SS). Localized to the plant cell cytoplasm.
Interaction partners:
- Flagellin
- HopF
- Effector protein HopM1
- Type III effector HopAI1
Sequence:
MAGINRAGPSGAYFVGHTDPEPVSGQAHGSGSGASSSNSPQVQPRPSNTPPSNAPAPPPTGRERLSRSTALSRQTREWLEQGMPTAEDASVRRRPQVTADAATPRAEARRTPEATADASAPRRGAVAHANSIVQQLVSEGADISHTRNMLRNAMNGDAVAFSRVEQNIFRQHFPNMPMHGISRDSELAIELRGALRRAVHQQAASAPVRSPTPTPASPAASSSGSSQRSLFGRFARLMAPNQGRSSNTAASQTPVDRSPPRVNQRPIRVDRAAMRNRGNDEADAALRGLVQQGVNLEHLRTALERHVMQRLPIPLDIGSALQNVGINPSIDLGESLVQHPLLNLNVALNRMLGLRPSAERAPRPAVPVAPATASRRPDGTRATRLRVMPEREDYENNVAYGVRLLNLNPGVGVRQAVAAFVTDRAERPAVVANIRAALDPIASQFSQLRTISKADAESEELGFKDAADHHTDDVTHCLFGGELSLSNPDQQVIGLAGNPTDTSQPYSQEGNKDLAFMDMKKLAQFLAGKPEHPMTRETLNAENIAKYAFRIVP
Protein: Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (O35379)
Organism: Mus musculus (Mouse)
Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P33527}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P33527}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Broad substrate specificity ATP-binding cassette transporter ABCG2
Sequence:
MALRSFCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRHDRGYIQMTHLNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVLLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAKDAGLV
Protein: Ribosome biogenesis protein BRX1 homolog 2 (AtBRX1-2) (Q9C928)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in pre-rRNA processing and required for biogenesis of the large (60S) ribosomal subunit. Required for proper development.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:25605960}. Note=Associates with 60S pre-ribosomes. {ECO:0000269|PubMed:25605960}.
Interaction partners:
- Probable rRNA-processing protein EBP2 homolog
- AT5g04600/T32M21_200
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Ribosome biogenesis protein WDR12 homolog
- AT5g20600/F7C8_190
- Probable ribosome biogenesis protein RLP24
- Nucleolar complex-associated protein 3
- At4g01560
- Ribosome biogenesis protein BOP1 homolog
- Ribosome production factor 2 homolog
Sequence:
MGRKRKHSETEAPAPVKKSDEPAPDRPKRTLLGWKDKSEGEAEKAKALTSSGFKNKEKVLVTCSRRISFRYRSLMLNIVSLLPHCKKDSKVEAKSSKGATLNELIELKNSNSCLFFECRKHKDLYMWMVKSPNGPSVKFLVKAVHAMEEMKLTGNHLKGSRPLLTFSSNFDKDAHWKLLKEMLTQVFGIPKEHRKSKPYHDHVFVFSIVDEHIWFRNYQISVPHNESDKIAKGGLDKMTLIEVGPRFCLNPIKIFAGSFGGPTLYENPLYVSPNQIRALEKRNKAGKFAKKIKAKTRKKMHELSNPLEPDEFADMWKDDE
Protein: Auxin-responsive protein IAA1 (Indoleacetic acid-induced protein 1) (P49677)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin response factor 5
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 7
- Auxin response factor 19
- Auxin transporter protein 1
- Auxin response factor 8
- Auxin-responsive protein IAA2
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA16
- Auxin-responsive protein IAA3
Sequence:
MEVTNGLNLKDTELRLGLPGAQEEQQLELSCVRSNNKRKNNDSTEESAPPPAKTQIVGWPPVRSNRKNNNNKNVSYVKVSMDGAPYLRKIDLKMYKNYPELLKALENMFKFTVGEYSEREGYKGSGFVPTYEDKDGDWMLVGDVPWDMFSSSCQKLRIMKGSEAPTAL
Protein: Porin (Porin OprE) (Porin-like protein NicP) (Protein E1) (Q51510)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MKSRKINKSRLALAITAGTLGALAQQAVAAGFIEDSKASLTLRNFYINTDNRNGTASPSKQEEWGQGFILNYQSGFTQGTVGFGVDALGLLGVRLDGGGRAGKSGLDRQPGTVFPLESNGEPVHDFASLGLTAKAKVSNTEFRYGTLQPKLPVVTYNDGRLLPVTFEGGQVTSTDLKDFTLVAGQLEHSKGRNSTDNRSLSIAGANGSSASSRDSNKFYYAGGDYKVNKDLTLQYYYGNLDDFYKQHFLGLIHNWQIGPGVLKTDLRAFDSSSDGKNGSRSGRADGYVSSGYYGSGVTKGEVDNRAFSGLFTYTVSGHSIGAGYQILNGDSDFPFLNRGDGEGSTAYLITDVQIGKFQRAGERTWQVRYGYDFATVGVPGLTFNTIYLSGDKIKTARGDQSEWERDISLAYVIPDGTFKGLGFTWKNASFRSGLPAAGSSNNQRDQDENRLIVSYTLPLL