wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome c oxidase assembly protein COX14 (Q8BH51)
Organism: Mus musculus (Mouse)
Function: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96I36}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome c oxidase assembly factor 3 homolog, mitochondrial
- HIG1 domain family member 2A
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase iron-sulfur protein 5
- Surfeit locus protein 1
- Cytochrome b-c1 complex subunit 8
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- Cytochrome c oxidase subunit 5B, mitochondrial
- Putative protein MSS51 homolog, mitochondrial
Sequence:
MPSAKQLADIGYKTFSASMMLLTVYGGYLCSVRAYRYLQLRSARRQAAEEQKTSGVL
Protein: Aminotransferase-like, plant mobile domain family protein (F4I9K2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Golgin family A protein
- AT2G24420 protein
- WPP domain-interacting tail-anchored protein 2
- AT4G31340 protein
Sequence:
MMDSSKESSLIETHFLKPYVTSIDGAVAELPRHRLSVSSSDLNESFSRISFNGFWSAQPNFKSWAKKMEALHEPIWRKAGIFEAIKASMYKIRKNQSLLLALVEKWCPETKSFLFPWGEATITLEDVLVLLGFSVQGSPVFAPLESSEMRDSVEKLEKARLENRGQDGLVRQNLWVSSFLGRGDQMEHEAFLAFWLSQFVFPDMCRRSISTKVLPMAVRLARGERIAFAPAVLARLYRDLGQIQASAREKSTPNVTLKSLFKLVQLWAWERFKSTSPKARVIPKGEPRISRWHSQTSKNVRLNLVDFDWRPYTKPLQIWNPPRFYPEEAMWMTVDDNLDDGFVSFARCMRVSQLVGVGIVEDYYPNRVAMQFGLAQDLPGLVTDHSSFTEKEAWDGYNKSLDGLMLYIPSRVATTSVTERYRDWWLKSISKFFLDSSESTETFDASNTIDHYDNNDEDDELLPLGQVLQNFGESFLKKLERCRARRLAKNHRFKINKDKIGDGGASASTELPLSQLFKKEVMKRTSEHLKNKGRKRAREDDVSSMDHKDDDVTIAQMIKSRRNDECGSKGKKSSMVQRPSNENNSSDPLVDSNGGIIDISVSPSETRQTCDDELHVDRSKKEELVHEDEEKQRSNENLCSEAEKEEDIDERLKQRKLAIEEIALKLETRVMEVEKSLTMIRKWKTRGNQTNHRVSA
Protein: Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (Q9WTQ6)
Organism: Rattus norvegicus (Rat)
Function: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K4K2}.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- Peroxisome proliferator-activated receptor alpha
- RAC-gamma serine/threonine-protein kinase
- Cyclic AMP-dependent transcription factor ATF-4
- COP1, E3 ubiquitin ligase
- Glutathione-specific gamma-glutamylcyclotransferase 1
- DNA damage-inducible transcript 3 protein
- Asparagine synthetase
Sequence:
MRATSLAASADVPCRKKPLEFDDNIDVECPVLKRVRDEPEPGPTPSLPPASDLSPAVAPATRLGPYILLEREQGNCTYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSQLLYTFFTKTHGDLHSLVRSRRGIPEPEAAALFRQMASAVAHCHKHGLILRDLKLRRFVFSNCERTKLVLENLEDACVMTGPDDSLWDKHACPAYVGPEILSSRPSYSGRAADVWSLGVALFTMLAGRYPFQDSEPALLFGKIRRGTFALPEGLSASARCLIRCLLRREPSERLVALGILLHPWLREDCSQVSPPRSDRREMDQVVPDGPQLEEAEEGEVGLYG
Protein: Trafficking protein particle complex subunit 5 (Q7K2Q8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222, ECO:0000256|PIRNR:PIRNR017479}.
Interaction partners:
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Probable trafficking protein particle complex subunit 2
- FI18195p1
- Trafficking protein particle complex subunit 11
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 10
- Protein brunelleschi
Sequence:
MEKLEALKISSMRPRSNILDRPLSKGKTEVSQSIVALLFSEIVQYSQSRVFTVPELQTRLHDLGQDVGTRIIDLYFVRERSSKRETKLTQMLLFVKTTVWKNLFGKEAEKLEHANDDERTYYIIEKEPLVNTFISVPKDKGSLNCANFTAGIVEAVLTNCGFPCKVTAHWHKGTTYMVKFEDFVIARDKQMEEK
Protein: ATP synthase subunit e, mitochondrial (ATPase subunit e) (Translocase of the inner membrane protein 11) (P81449)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase subunit g, mitochondrial
- ATP synthase subunit 4
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit K
- ATP synthase subunit J, mitochondrial
- ATP synthase subunit H
- ATP synthase subunit d
- MICOS complex subunit MIC60
- ATP synthase subunit f
- ATP synthase subunit epsilon, mitochondrial
Sequence:
MSTVNVLRYSALGLGLFFGFRNDMILKCNAKKKEEQAQYEEKLKLVEEAKKEYAKLHPVVTPKDVPANASFNLEDPNIDFERVILNAVESLKEAST
Protein: Probable aminopeptidase YDR415C (EC 3.4.11.-) (Q04033)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Putative uncharacterized protein YGR182C
- Uncharacterized protein YOR343C
- Uncharacterized protein YMR265C
- Protein YLR162W
- Uncharacterized protein YER053C-A
- 3'
- Protein transport protein TIP20
Sequence:
MRIQSLFVLFNVAIIAWSYPYEPLRVLQVGENEVMEVPESEKLNLRRRGVKFFDVTKHTSFLPFFNKEEEPTVPTYNYPPEISNKEVVDDSIKNIDKGSMHKNLAKFTSFYTRYYKSDHGFESAEWLAATIANITKDIPQDTLTIEHFDHKEWKQYSIIVRVTGSTTPEDIIIIGSHQDSINLLLPSIMAAPGADDNGSGTVTNMEALRLYTENFLKRGFRPNNTVEFHFYSAEEGGLLGSLDVFTAYAKQKKHVRAMLQQDMTGYVSDPEDEHVGIVTDYTTPALTDFIKLIINSYLSIPYRDTQCGYACSDHGSATRNGFPGSFVIESEFKKTNKYIHSTMDTLDRLSLAHMAEHTKIVLGVIIELGSWSAW
Protein: Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) (Q02253)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:2768248}.
Interaction partners:
- 3-hydroxyisobutyrate dehydrogenase, mitochondrial
- Propionyl-CoA carboxylase beta chain, mitochondrial
- 4-aminobutyrate aminotransferase, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Peroxisomal bifunctional enzyme
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Acetyl-coenzyme A synthetase
- Trifunctional enzyme subunit beta, mitochondrial
- 4-trimethylaminobutyraldehyde dehydrogenase
- Alpha-aminoadipic semialdehyde dehydrogenase
Sequence:
MAAAVAAAAAVRSRILQVSSKVNSTWYPASSFSSSSVPTVKLFIDGKFVESKSDKWIDIHNPATNEVVGRVPQSTKAEMEAAVAACKRAFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVERAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGAKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIFTTNGAIARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
Protein: BCL3 transcription coactivator (H7C0A2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVSRGSCGHAPCTRVSAGWLQVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPS
Protein: Protein EFFECTOR OF TRANSCRIPTION 2 (AtET2) (F4K933)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator involved in the regulation of cell differentiation in meristems. Probably regulates the expression of various KNAT genes involved in the maintenance of the cells in an undifferentiated, merismastic state. Plays a role in the regulation of gibberellin 20 oxidase and the gibberellin-regulated protein GASA4. Localizes in the nucleus during the cellular differentiation state and may act via a single strand cutting domain. Transcriptional regulator required for the induction of dormancy during late seed development. Interacts genetically with FUS3 and may be component of the same regulatory pathway during embryogenesis. Binds both linear and supercoiled DNA without sequence preference.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17991462}. Nucleus {ECO:0000269|PubMed:17991462}. Note=Localizes to the cytoplasm in non-differentiating cells and to the nucleus in differentiating cells. {ECO:0000269|PubMed:17991462}.
Interaction partners:
- At4g31150
- Plasmodesmata-located protein 3
- GATA transcription factor 7
- Callose synthase 10
- Dof zinc finger protein DOF4.6
- 24-methylenesterol C-methyltransferase 2
- Plasmodesmata-located protein 2
- Myb-related protein 2
Sequence:
MEFGDGVSFAVVPTVFKREDYKRTKHDTVFSKWQVLIGSNDWEDFKNGKDGVGRYRVQNLPRKSCPGLYELGVAVIGQEQCRKLEPDIVLASYLGQAESVRSRLQRYGRSGAHLRNVNNLNDCETIESPVKAVTGGLFEDIFSKGGSILYRWAPMGSKREAEATEGMLLSTFDYAWNKGSNGERRQLDLLKKLGDREFMSKRKSGISRMLFPFLRNQVGIRIKGEKHVLKEERKLTCDVDEEKSNNFLTSILKLTRSRPQPVSDRFDEVDGSCSDIVCGVLLEDGGCCIRSPVKGRKRCIEHKGQRVCRVSPEKQTPPKSEIFTGQDHHNHKDSDVVCGVILPDMEPCNKRPVPGRKRCEDHKGMRINAFLFLLNQTDREKTVKDEKPDPESHTESIEEEALTRFCEATTKNGLPCTRSSPKGSKRCWQHKEKTSSDTSPVYFQPEAAKNVACGVKLGNGLICERSPVKGRKRCEEHKGMRIT
Protein: Polar tube protein 2 (Q8SRT0)
Organism: Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Function: Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.
Subcellular location: Spore polar tube {ECO:0000269|PubMed:11159998}.
Interaction partners:
Sequence:
MLLLLAITAVVSATMVHPSAVVPQPAAPLHVVPPQQQMGMVNGCTSKKLEGAEIMRRNMIECQKRSSEATKAMIERANEKAVESFNKEVSKGPSQKDGGQCIEKAVQGTDRCILAGIIDKAVNKRKYRISDVENSTSLYRGDKLIALIVNVDYGLQPITKPKKKKSKIMANLPQPKREMYFNQIGQLVGARGTFPQENKEDCKPCEGPKKTVETTSEKCNLGCELKGTSALISKAIQKKEVKDTKEGEKSASQDSDGEGTAEDAEVQQPSADGEGLE
Protein: Ly-6-related protein ODR-2 isoform 16 (Protein quiver) (Q9BMH9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTSQFTKLFSFILANVHDPAAPEDAALRLPCYSCMSPYLEDHYPYISHLYRKPLSFDTHCDKHSLETSYLYSKNCSDMCVTLRINDVVGGRRRHGYMRGCLSDLHGYNHSLIRTLAERQGCLDTTARELFLPTAQRQELEPSRLSLCACHNNLCNFSVSPPCFFIFLFVILVIFLMR
Protein: Glycosyltransferase WbpX (G3XCU3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- ABC subunit of A-band LPS efflux transporter
- Alginate biosynthesis protein AlgA
- D-rhamnosyltransferase WbpZ
- Transport permease protein
- Glycosyltransferase WbpY
- GDP-6-deoxy-D-mannose reductase
- GDP-mannose 4,6-dehydratase
- Glycosyltransferase
- Glycosyltransferase
- Class I SAM-dependent methyltransferase
Sequence:
MTRLLVECTYVFEHPKVNSGIQRVVRNVIRELPEADETVECIPVAMLDGTLYQVHSLAPLDPRPHSPLVRLRILVERAANYFWLGQRTLEKRRPFRSSPWARRLLYVACRLFAFAFLSIPLRLLDRILGKQQPAPVRATPLEHRAGDQLVLLDSSWHADFFPLAERLKSEGVGIVSVIYDLIPLTHPQFCDAGLVKVFNHWFDWIAATADGYVAISETIRDEVRAEMLRRIGPEKVAQRWFDYFHLGSELDLVEDGASVEPDLLRMFKAKAPVFLMVSTIEPRKNHGYLLDAFERAWAQGSQARLCIAGRIGWKCEALVERVRQHPELNKRLFMFNDLSDKSLEYAYSHAASLVFPSYVEGFGLPLVEAMQRGLPAMGSDIPVFREIGGEFMAYFDLADPQTLANLVTRFEATGEFPAERPVGEWRWIGWHEASRQLIARILLALGKAPAHGEAVHADCG
Protein: RE54080p (Zinc transporter 35C, isoform A) (Q9V471)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- IP18018p
- SD10554p
- Zinc/iron regulated transporter-related protein 42C.2
- Copper transport protein
- Metallothionein-2
- Xanthine dehydrogenase
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- FI23527p1
- P-type Cu
- FI24038p1
Sequence:
MSRNEDTPIAKRDSGRTRRSNYGTAPSFHLMEQGQPGVNVVAGNGNNNHPATPATPAQIFCLHGRSNNVEVRDHCHRARSEGVDVKARRKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDVIQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAATSAVHLRYNFFETTIQIEDYTAQMESCLQCNVPEK
Protein: Uncharacterized protein, isoform B (Uncharacterized protein, isoform C) (A1Z6Y2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein
- Accessory gland-specific peptide 26Aa
Sequence:
MRLFPVYFAIIFLFQYDVYSISDNLKTELRSWFGNIKQLHNPATLNTLKMLCVVEVMRGSKHRINVGNIDILNKNTLENFIKLPSFKMPNITIVIVEDELSKIARSGSQYKEREMEKLVQHFKECILAKLKALS
Protein: Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) (Q80TJ1)
Organism: Mus musculus (Mouse)
Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
Subcellular location: Synapse {ECO:0000269|PubMed:14530279}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:Q62717}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62717}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. {ECO:0000269|PubMed:14530279, ECO:0000269|PubMed:15820695}.
Interaction partners:
Sequence:
MLDPSSSEEESDEILEEERGKDVLGSAASGARLSPSRTSEGSAGSAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFSGLKDADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNIICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGISMKDSDEEDEEDD
Protein: ATPase family protein 2 homolog (EC 3.6.4.10) (Cell division cycle-related protein 48.3) (Q21222)
Organism: Caenorhabditis elegans
Function: ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18854144}.
Interaction partners:
- UBX domain-containing protein 2
- UBX domain-containing protein 1
- Nuclear protein localization protein 4 homolog 2
- Nuclear protein localization protein 4 homolog 1
- UBX domain-containing protein 6
- UBX domain-containing protein 4
- Ubiquitin fusion degradation protein 1 homolog
- Transitional endoplasmic reticulum ATPase homolog 2
- Transitional endoplasmic reticulum ATPase homolog 1
- Derlin-2
Sequence:
MSSAKKKPSLVTCPQCNAVVLTKDSLRHQDFCGKPVVESEIACAQNGTLRGFNVAVDKAEGFLPPDAVGWEKEHSILINQQTMESLGLLARQPVRIIHSSDSFIGIVWPCKEVALLKVSIISSRIARERMITLESCGRVEKLKSLSVTVKTSLTLNPALSGFLEAYLSHSYLQYNSSVDLKYLGQNVTVTPEEPIESKMSAMGIDDDKKRNSKVVSTAVGYKIQILNASAEGSTSDVLQTLPTDLSNIGGCFTAKQVLEDYVISPVRQKESPCSVLIWGLPGSGKTLLLKEVALVLSGSTTYIGSCEELMELNGVTTGNIVIVDVNELEKENTKANRALSFLLGDEKKCVILCVRSSETLDIGFRVRFPIEAEITVPTQDERLDILSKIGNIYNFPLELHLDVARHTHGFTGGDLCSLLKAAKFARGRTHLERVNDARKRIRPTGIRQFILEVPNVSWNDIGGNEELKLEIQQAVIWPQKHPEAFERFGIDPPAGILLYGPPGCSKTLIARALASEAKMNFLAVKGPELFSKWVGDSEKAIRDLFSRARQVAPTIVFFDEIDAVGSSRGSEKSSGVSDRVLAQLLTELDGLEKSSRVILLAATNRPDQLDSALLRPGRLDRAIYVGLPCEVTRRAILEMRTKKMKFDDTVRTIDKLVEKTSGYSGAELVAVCRTAAMFAMRESIDATIVQWTHFEQALAAVVSRTEAYLLEIYDDFKAGRASNA
Protein: Matrix metalloproteinase-2 (Dm2-MMP) (EC 3.4.24.-) (Q8MPP3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has metalloproteinase activity. Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue. Required for growth of the dorsal air sac primordium and development of the dorsal air sacs. Promotes embryonic motor axon fasciculation. Cleaves and activates frac to promote motor axon bundling during outgrowth. Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow. Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation. Plays a role in wound healing. Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions. Required for posterior follicle cell degradation and ovulation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11967260, ECO:0000269|PubMed:25267296}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Tissue inhibitor of metalloproteinase
- Matrix metalloproteinase 1, isoform C
- Furin-like protease 1, isoforms 1/1-X/2
- Neurogenic locus Notch protein
- Viking, isoform A
- Low-density lipoprotein receptor-related protein
- Protein kinase C, brain isozyme
- DE-cadherin
- Peptidase S1 domain-containing protein
- FI18763p1
Sequence:
MFSKYVLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEETGRSGSRELRINHFILSILLLAIANWRS
Protein: L-type lectin-domain containing receptor kinase SIT1 (EC 2.7.11.1) (Protein SALT INTOLERANCE 1) (Q6H7D2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Lectin-domain containing receptor kinase involved in salt stress response. Acts as negative regulator of salt tolerance. Mediates salt sensitivity by phosphorylating and activating MPK3 and MPK6. Promotes ethylene production and mediates salt-induced ethylene signaling. Promotes the accumulation of reactive oxygen species (ROS) under salt stress conditions. Its kinase activity is triggered by salt stress and is required for its function in salt stress response. Phosphorylates B'KAPPA, a B regulatory subunit of phosphatase 2A (PP2A).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24907341}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRRPELIMRSLPLILFLSLGSFHLAAAAVDDQFTFDGFAGVNLTLDGTAVVTPGGLLMLTNGTTLLKGHAFYPSPLRFFHEATSGGGSSTVRSFSTAFVFGIVSEYADLSSPGLAFVVAKSRDFSSALQSQYMGLANARNNGNASNHFLAVELDTIVNAEFGDMSDNHVGIDVDGLASAAADDAGYHDDRTGAFVNMSLLSRAAARVWVDFDARTSLVNVTMAPLELPKPTTPLLSAAVNLSAVIEDEAYVGFSSSTGVVASRHYVLAWSFKMDGPAPSLNVSKLPALPVTIARAPSNVLKILLPIASAALVSALAIAVLVIHRRRRRYAELKEEWEVAFGPHRFSYKDLFRATNGFSDERLLGFGGFGRVYKGVLLVSRVEIAVKKVSHESRQGMKEFIAEVVSIGQLRHRNLVQLLGYCRQKGELLLVYDYMPNGSLDKYLYAENSKILSWAQRFRIIKGIASSILYLHEDWEQVVLHRDIKASNVLLDAEMNCRLGDFGLARLYDRGTDPHTTHVVGTIGYLAPELGHTGRPSKASDIFAFGVFMLEVTCGRRPVLQDTNGGQLLLVDMVLEHWRQGTVTDAVDPRLQGDFAVEEASLVLKLCLLCSHPLPSARPGIRQVVQLLDGAMPLPELSQAHLSCNMLALMQNQMGNSCSVASSVAGNISDIPRAR
Protein: Oxidoreductase HTATIP2 (EC 1.1.1.-) (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2) (Q9BUP3)
Organism: Homo sapiens (Human)
Function: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15282309}. Nucleus envelope {ECO:0000269|PubMed:15282309}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Sequence:
MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP