wanglab/gogpt-training-data huggingface dataset:
Protein: Claudin-7 (Q9Z261)
Organism: Mus musculus (Mouse)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O95471}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:O95471}. Cell junction, tight junction {ECO:0000250|UniProtKB:O95471}. Note=Colocalizes with EPCAM at the basolateral cell membrane and tight junction. {ECO:0000250|UniProtKB:O95471}.
Interaction partners:
- Epithelial cell adhesion molecule
- Occludin
- Tight junction protein 1
- Tight junction protein ZO-3
- MARVEL domain-containing protein 2
- Claudin-3
- Claudin-4
- Tumor-associated calcium signal transducer 2
- CD44 antigen
- AP-1 complex subunit mu-2
Sequence:
MANSGLQLLGFSMAMLGWVGLIASTAIPQWQMSSYAGDNIITAQAMYKGLWMECVTQSTGMMSCKMYDSVLALPGALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKAKKARIAMTGGIVFIVAGLAALVACSWIGHQIVTDFYNPLTPMNVKYEFGPAIFIGWAGSALVLLGGALLSCSCPGSESKAAYRAPRSYPKSNSSKEYV
Protein: Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 (EC 3.1.3.67) (P53916)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels.
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34
- Phosphatidylinositol 4-phosphate 5-kinase MSS4
- Clathrin heavy chain
- Polyphosphatidylinositol phosphatase INP53
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51
- Polyphosphatidylinositol phosphatase INP52
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol 3-phosphate 5-kinase FAB1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
Sequence:
MREEGSELEMEKGFLKWKPVNLMKKILSLPMKKTKNDIGLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLAKMTFLRPSSLITSESAIVTTKIQHYNDDRNALLTRKVVYSDIMAHECGGNMTFIFGRDYLTLENDCRIEFTLGTSKSKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYFQVERLKRDEMLGTTISWQELDGFGELSTHGLKLFQALKLEWEII
Protein: Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) (IMPDH2) (P9WKI7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Does not catalyze the reverse reaction, i.e. the conversion of XMP to IMP. Appears to be essential for the optimal growth of M.tuberculosis.
Interaction partners:
- GMP synthase
- Adenylosuccinate synthetase
- Hypoxanthine-guanine phosphoribosyltransferase
- Uncharacterized oxidoreductase Rv3410c
- Bifunctional purine biosynthesis protein PurH
- GMP reductase
- Adenylosuccinate lyase
- Amidophosphoribosyltransferase
- dITP/XTP pyrophosphatase
- Nucleoside triphosphate pyrophosphohydrolase
Sequence:
MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit) (Q9VTU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- Acyl carrier protein, mitochondrial
- GM23292p
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 12
Sequence:
MVGWSRLLSPAAKFASYRAVLQEPACRNALHQQLRRMGGDHGHHQMIIKPSRFQWDKFKDLLHFYVMLGVIPVTALVLYANIFVGPAQLAEIPEGYEPKHWEYEKHPISRFISRYILNSDQQNYEKSLHYLYEENEKAQIRLLEDEVRRKMSERNDYQAYYYRPSVAKYHRISKEAADELEALRGD
Protein: Lhb protein (Luteinizing hormone beta 2) (Luteinizing hormone subunit beta) (Luteinizing hormone, beta polypeptide) (Lutropin subunit beta precursor) (Q6TCF5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU004069}.
Interaction partners:
- Glycoprotein hormones alpha chain
- Lutropin-choriogonadotropic hormone receptor
- Progonadoliberin
- Progonadoliberin
- Thyrotropin receptor
- Kisspeptin
- KiSS-1 metastasis suppressor
- FMRFamide related peptide 1
- Aromatase
- Prolactin.
Sequence:
MLLAGNGVFFLFSLFFLLAAAQSLVFPRCELVNETVSVEKEGCPKCLVFQTTICSGHCVTRDPVYKSPFSTVHQTVCTYRDVRYETINLPDCSAGVDPQITYPVALSCDCSLCTINTSDCTIQSLQPDFCMSQREDFPAY
Protein: Psp operon transcriptional activator (Phage shock protein F) (P37344)
Organism: Escherichia coli (strain K12)
Function: Transcriptional activator for the phage shock protein (psp) operon (pspABCDE) and pspG gene.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phage shock protein A
- RNA polymerase sigma-54 factor
- Phage shock protein C
- Phage shock protein B
- Phage shock protein G
- Phage shock protein D
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
Sequence:
MAEYKDNLLGEANSFLEVLEQVSHLAPLDKPVLIIGERGTGKELIASRLHYLSSRWQGPFISLNCAALNENLLDSELFGHEAGAFTGAQKRHPGRFERADGGTLFLDELATAPMMVQEKLLRVIEYGELERVGGSQPLQVNVRLVCATNADLPAMVNEGTFRADLLDRLAFDVVQLPPLRERESDIMLMAEYFAIQMCREIKLPLFPGFTERARETLLNYRWPGNIRELKNVVERSVYRHGTSDYPLDDIIIDPFKRRPPEDAIAVSETTSLPTLPLDLREFQMQQEKELLQLSLQQGKYNQKRAAELLGLTYHQFRALLKKHQI
Protein: F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein) (Q9UKA1)
Organism: Homo sapiens (Human)
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}. Nucleus {ECO:0000269|PubMed:24157836}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- Iron-responsive element-binding protein 2
- Cytoplasmic aconitate hydratase
- E3 ubiquitin-protein ligase RBX1
- Cytosolic iron-sulfur assembly component 2B
- MMS19 nucleotide excision repair protein homolog
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
- F-box/LRR-repeat protein 14
- E3 ubiquitin-protein ligase HERC2
Sequence:
MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE
Protein: BTB/POZ domain and ankyrin repeat-containing protein NH5.2 (Q2QXZ2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in defense response against pathogens.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:S4VGD0}. Cytoplasm {ECO:0000250|UniProtKB:S4VGD0}.
Interaction partners:
- Os01g0314700 protein
- Transcription factor TGAL10
- Transcription factor TGA2.3
- Transcription factor TGAL1
- Kinesin-like protein KIN-14I
- Transcription factor TGA2.1
- Transcription factor TGA2.2
- BTB/POZ domain and ankyrin repeat-containing protein NPR1
- Transcription factor TGAL6
Sequence:
MSSEDSLKSLSLDYLNLLINGQAFSDVAFSVEGRLVHAHRCVLAARSLFFRKLFCGLDPNHQPPPPPPPPLNWPTAGGGGGGSGGGGRGGAGGGGGAPATPELVIPVSSIRYEVLVLVLQFLYSGQASVAAPKSGPLPGCGARGCWHTRCGAAVDLALDTLAAARSFGVEQLALLVQKQLESMVKEASVDDVMKVLMASRKFEMQELWATCSHLVARSGLSADLLAKHLPIDVVAKIEEIRAKSPLAAAAAPRSPFLTHHYLPMNPASSAADRDNKIRRMRRALDAADIELVKLMVMGEGLDLDDALAVHYAVQHCNRDVVKALLELGAADVNSRAGPTGKTALHLAAEMVSPDMVSVLLDHHADPNSRTLDGVTPLDVLRSLTSEFLFKGAVPGLTHIEPNKLRLCLELVQSAVMVTTRDDGAPVTGGEAGGSDGGNFPRSDADDSLVSLTMNSTLMYQGQEMAAAVAAGEGRKSNNGRGSPPPAMYFPNGFA
Protein: SH3 domain-containing protein (Q10929)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Wiskott-Aldrich syndrome protein family member
- Membrane-associated protein gex-3
- Cytoplasmic FMR1-interacting protein homolog
- Tyrosine-protein kinase abl-1
- Protein BRICK1
- Abnormal cell migration protein 10
- Ras-related protein ced-10
- SH3 domain-containing protein
- CRIB domain-containing protein
- Transducer of Cdc42-dependent actin assembly protein 1 homolog
Sequence:
MSVNDLQELIERRIPDNRAQLETSHANLQQVAAYCEDNYIQSNNKSAALEESKKFAIQALASVAYQINKMVTDLHDMLALQTDKVNSLTNQVQYVSQVVDVHKEKLARREIGSLTTNKTLFKQPKIIAPAIPDEKQRYQRTPIDFSVLDGIGHGVRTSDPPRAAPISRATSSISGSSPSQFHNESPAYGVYAGERTATLGRTMRPYAPSIAPSDYRLPQVTPQSESRIGRQMSHGSEFGDHMSGGGGSGSQHGSSDYNSIYQPDRYGTIRAGGRTTVDGSFSIPRLSSAQSSAGGPESPTFPLPPPAMNYTGYVAPGSVVQQQQQQQMQQQNYGTIRKSTVNRHDLPPPPNSLLTGMSSRMPTQDDMDDLPPPPESVGGSSAYGVFAGRTESYSSSQPPSLFDTSAGWMPNEYLEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDDDWYEGVLDGVTGLFPGNYVVPV
Protein: Uncharacterized protein (Q94B54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASSAPQGSVDPLTGKDPAKALTAVASGFFENVKKNKQSFFQFAAMTGILLLSFRSVSQKYRIHDLEEDTAVLKKEQDSLTDRMSKIKSDLLHQASIDSSGVFASRLRLLFGEDKK
Protein: short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) (H0YN10)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVE
Protein: Phenylalanine ammonia-lyase 1 (EC 4.3.1.24) (P35510)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Trans-cinnamate 4-monooxygenase
- 4-coumarate--CoA ligase 1
- 4-coumarate--CoA ligase 2
- 4-coumarate--CoA ligase 3
- 4-coumarate--CoA ligase 4
- 4-coumarate--CoA ligase-like 7
- 4-coumarate--CoA ligase-like 9
- 4-coumarate--CoA ligase-like 6
- 4-coumarate--CoA ligase-like 1
- Chalcone synthase
Sequence:
MEINGAHKSNGGGVDAMLCGGDIKTKNMVINAEDPLNWGAAAEQMKGSHLDEVKRMVAEFRKPVVNLGGETLTIGQVAAISTIGNSVKVELSETARAGVNASSDWVMESMNKGTDSYGVTTGFGATSHRRTKNGVALQKELIRFLNAGIFGSTKETSHTLPHSATRAAMLVRINTLLQGFSGIRFEILEAITSFLNNNITPSLPLRGTITASGDLVPLSYIAGLLTGRPNSKATGPNGEALTAEEAFKLAGISSGFFDLQPKEGLALVNGTAVGSGMASMVLFETNVLSVLAEILSAVFAEVMSGKPEFTDHLTHRLKHHPGQIEAAAIMEHILDGSSYMKLAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRYATKSIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLTASRNPSLDYGFKGAEIAMASYCSELQYLANPVTSHVQSAEQHNQDVNSLGLISSRKTSEAVDILKLMSTTFLVAICQAVDLRHLEENLRQTVKNTVSQVAKKVLTTGVNGELHPSRFCEKDLLKVVDREQVYTYADDPCSATYPLIQKLRQVIVDHALINGESEKNAVTSIFHKIGAFEEELKAVLPKEVEAARAAYDNGTSAIPNRIKECRSYPLYRFVREELGTELLTGEKVTSPGEEFDKVFTAICEGKIIDPMMECLNEWNGAPIPIC
Protein: Meiotic driver wtf13 (O74420)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus; the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, leading to poisoning of all progeny that do not inherit the allele.
Subcellular location: [Isoform 1]: Spore membrane {ECO:0000255, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:32032353}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. {ECO:0000250|UniProtKB:A0A218N034}.; SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm {ECO:0000269|PubMed:30475921}. Cytoplasm {ECO:0000250|UniProtKB:A0A218N034}. Spore membrane {ECO:0000255, ECO:0000269|PubMed:30475921, ECO:0000269|PubMed:32032353}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1. {ECO:0000250|UniProtKB:A0A218N034}.
Interaction partners:
Sequence:
MKNKDYPLRSSMDELSTKNDNEIDLEKGPLPEYNSEDGSTLPPYSEIWKYIKTVSEDSSTGPTEIANPNVERRQEFKDSHPNIYSLLRLLISVLAVIVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPIVFIAIFCFFETWTQAVAQCIKVTVIFLAQCVKVTAISLAQCVKVTAVFLAKCVKVTAVFLAKCVKVIAVGLYNSKKDLVVTIWLAWVVICFILFGCVKDGRLNLNKALICSTCSISAALFFILLLVCIPIWTLKHMLFGLFQVLGVQSCVVIVTKGLMYLFDKHIDATGYEIEASSLFVIGNFLFFYEMERPGALKRMPKFIGNGIASFLGGLGNAFGGIGNAFGGIGNAIGRIGNAFRGANDNNDIPLGEMDVESEV
Protein: Aureobasidin-resistance protein (C8V8N6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- DUF1753-domain-containing protein
Sequence:
MNQTLPTWKDRTQNQFGKLQIQVPWRSIQLLVPHRMRRKLRSKLRSRASPTSSIASLQTSLSPADTLRSLQSHRWTVYDFQYLLLLIVGIFSLTVIESPGPLGKTAIFSMLLFSLLIPMTRQFFLPFLPIAGWLLFFYACQFIPSDWRPAIWVRVLPALENILYGANISNILSAHQNVVLDVLAWLPYGICHYGAPFVCSLIMFIFGPPGTVPLFARTFGYISMTAVTIQLFFPCSPPWYENRYGLAPADYSIQGDPAGLARIDKLFGIDLYTSGFHQSPVVFGAFPSLHAADSTLAALFMSHVFPRMKPVFVTYTLWMWWATMYLSHHYAVDLVAGGLLAAIAFYFAKTRFLPRVQLDKTFRWDYDYVEFGESALEYGYGAAGYDGDFNLDSDEWTVGSSSSVSSGSLSPVDDHYSWETEALTSPHTDIESGRHTFSP
Protein: Melatonin receptor (Q9PT17)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
CYICHNLKYDKLFSNQNTVCYVILVWSLTVLAIVPNWFMESLQYDPRVYSCTFAQSVSSLYTITVVVVHFILPISIVTYCYLRIWILVLQVRRRVKPDTRPKIKPHDFHIFLTMFVVFVLFAVCWAPLNFIGLAVAINPRLGVNIPEWLFTASYFMAYFNS
Protein: MYND-type domain-containing protein (Q23084)
Organism: Caenorhabditis elegans
Interaction partners:
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase
- LITAF domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- Lysine-specific histone demethylase 1
- Lysine-specific demethylase 4
- Histone-lysine N-methyltransferase set-17
- Histone-lysine N-methyltransferase set-26
- SET domain-containing protein
- SET domain-containing protein
- SET domain-containing protein
Sequence:
MSSGDAPLEVVGVEKIGSKPRSKEFYPFAYSLLDCTKDDYCWTCLGENVELTCEQCKVAKFCSKQCETSGAIDHKYECGPLKKCPDLNTDERMLIRIVGRYKDIHSGKDKSIDGFYNNRESKRSVMEIWEHCADMKKDENAMKSFKKTYDRVKQFGDTNHLMDEEVTFQLHSRNFINRHSISNVDYLREIGKGLYLDLCKYDHSCRPNAIYSCNGIVAKLRALHDNVDLENVETTHYTYIELPPCKIQRRHMLKETWYFECHCERCDDPDDNWLTSVLCPVCISKTEYRKTIKLHGPEAYANPETLEIVCDRCSTTLDREYIFMALDGMRTIRRTVEGAEDETKDPIELLKIYQGALMTYERILPMSNAYFCQLIAAMIPLISRVSMTKKERLVASLDLHLKCETFVRYVYRHAHPSKAMHFLQMGQLHLELANDKDAARCLIEAHRIMDYLFGADHFLSKQTKGFMDHALSSLMQFQRNFVNVLDRVPEAKQALEERFMTADEKKALKDSEKNKRKRNNKKNKKIEQKNEQKSSGENGNSKTKGVEDGLEDLPELVAEM
Protein: Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) (Q9MYX0)
Organism: Macaca mulatta (Rhesus macaque)
Function: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P31645}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:P31652}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P31652}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes. Density of transporter molecules on the plasma membrane is itself regulated by STX1A. Density of transporter molecules on the plasma membrane is also regulated by serotonin (By similarity). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). {ECO:0000250|UniProtKB:P31645, ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857}.
Interaction partners:
- 5-hydroxytryptamine receptor 2A
- Amine oxidase
- Tryptophan 5-hydroxylase 2
- tryptophan 5-monooxygenase
- D
- Neurotrophic factor BDNF precursor form
- catechol O-methyltransferase
- 5-hydroxytryptamine receptor 1B
- 5-hydroxytryptamine receptor 1A
- Amine oxidase
Sequence:
METTPLNSQKQLSACKDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPAATTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSFVCIPTYIAYRLISTPGTFKERIIKSITPETPTEIPCGDVRLNAV
Protein: Microsomal glutathione S-transferase 3 (D4ADS4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Microsomal glutathione S-transferase 1
- Microsomal glutathione S-transferase 2
- Hematopoietic prostaglandin D synthase
- Glutathione S-transferase omega-1
- glutathione transferase
- Aldehyde dehydrogenase
- Glutathione S-transferase alpha-3
- Glutathione S-transferase kappa 1
- Glutathione S-transferase P
- Glutathione S-transferase Mu 4
Sequence:
MAVLSKEYGFVLLTGAASFVMVLHLAINVGKARKKYKVEYPVMYSTDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGVYHPRIASGLGVAWIIGRVLYAYGYYTGDPSKRYRGAVSSLALFALMGTTVCSAFQHLGWIKPGLGSGSRSCH
Protein: KIAA1937 protein (Q96PV1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
VLGGLLLLGVAQLGLFLEEKLREHLAEKEKLNEERLEQEEKLKAKIRQLTEEKAALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFGEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQK
Protein: Leucine-rich repeat-containing G protein-coupled receptor 2 (Q9BN18)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MHLPSNYTLFSHIFRFSLLFSPVLFGYFCNGYKKRKTNNPHRQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFSGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDTTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTKRGDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRRKQRRQPQQRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSENFCSSRSSSWRHGPPSSAPVPPGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLSSSRNDSSASATTASTSTFRLSRSSAGSSTPLPSIIGKWQTQNINI
Protein: DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4) (Q32PN8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Oligodendrocyte transcription factor 1
- Oligodendrocyte lineage transcription factor 2.
Sequence:
MKASVPVRPHKLPSSCSQLSLRYLSESSRCKMEDEDLFCLQYDMNDCYSRLKRLVPTIPQDKKVSKVEILQHVIDYILDLQLALETHPALLKQTSPPASTRTPLTQINTEQRTTGVNKEDSLFLCR
Protein: Leupaxin (Q99N69)
Organism: Mus musculus (Mouse)
Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
Subcellular location: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). {ECO:0000250}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 12
- Protein-tyrosine kinase 2-beta
- Vinculin
- Cytosolic purine 5'-nucleotidase
- Alpha-parvin
- ARF GTPase-activating protein GIT1
- Focal adhesion kinase 1
Sequence:
MEELDALLEELERCTFQDSEEYSNPVSCHLDQQSTEESKIPQTPKTLSSQGNTSPLKVQLVYATNIQEPNVYSEVQEPKESVLPPKTSAAAQLDELMAHLSEMQAKVSVKADTSRKPLPDQQDHKASLDSMLGDLEQELQDLGIATVPKGYCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEELGSSPFFERSGLAYCSKDYHRLFSPRCAYCAAPITDKVLTAMNKTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSSGSFFELDGRPFCELHYHHRRGTLCHDCGQPITGRCISAMGHKFHPEHFVCAFCLTQLPKGIFKEQNNKTYCEKCFTKLFSQ