Protein: Erythronolide synthase EryA2 (EC 2.3.1.94) (6-deoxyerythronolide B synthase II) (6-deoxyerythronolide-B synthase EryA2, modules 3 and 4) (DEBS 2) (ORF B) (Q03132)
Organism: Saccharopolyspora erythraea (Streptomyces erythraeus)
Function: Involved in the biosynthesis of antibiotic erythromycin via the biosynthesis of its aglycone precursor, 6-deoxyerythronolide B (6-dEB).
Interaction partners:
Sequence:
MTDSEKVAEYLRRATLDLRAARQRIRELESDPIAIVSMACRLPGGVNTPQRLWELLREGGETLSGFPTDRGWDLARLHHPDPDNPGTSYVDKGGFLDDAAGFDAEFFGVSPREAAAMDPQQRLLLETSWELVENAGIDPHSLRGTATGVFLGVAKFGYGEDTAAAEDVEGYSVTGVAPAVASGRISYTMGLEGPSISVDTACSSSLVALHLAVESLRKGESSMAVVGGAAVMATPGVFVDFSRQRALAADGRSKAFGAGADGFGFSEGVTLVLLERLSEARRNGHEVLAVVRGSALNQDGASNGLSAPSGPAQRRVIRQALESCGLEPGDVDAVEAHGTGTALGDPIEANALLDTYGRDRDADRPLWLGSVKSNIGHTQAAAGVTGLLKVVLALRNGELPATLHVEEPTPHVDWSSGGVALLAGNQPWRRGERTRRARVSAFGISGTNAHVIVEEAPEREHRETTAHDGRPVPLVVSARTTAALRAQAAQIAELLERPDADLAGVGLGLATTRARHEHRAAVVASTREEAVRGLREIAAGAATADAVVEGVTEVDGRNVVFLFPGQGSQWAGMGAELLSSSPVFAGKIRACDESMAPMQDWKVSDVLRQAPGAPGLDRVDVVQPVLFAVMVSLAELWRSYGVEPAAVVGHSQGEIAAAHVAGALTLEDAAKLVVGRSRLMRSLSGEGGMAAVALGEAAVRERLRPWQDRLSVAAVNGPRSVVVSGEPGALRAFSEDCAAEGIRVRDIDVDYASHSPQIERVREELLETTGDIAPRPARVTFHSTVESRSMDGTELDARYWYRNLRETVRFADAVTRLAESGYDAFIEVSPHPVVVQAVEEAVEEADGAEDAVVVGSLHRDGGDLSAFLRSMATAHVSGVDIRWDVALPGAAPFALPTYPFQRKRYWLQPAAPAAASDELAYRVSWTPIEKPESGNLDGDWLVVTPLISPEWTEMLCEAINANGGRALRCEVDTSASRTEMAQAVAQAGTGFRGVLSLLSSDESACRPGVPAGAVGLLTLVQALGDAGVDAPVWCLTQGAVRTPADDDLARPAQTTAHGFAQVAGLELPGRWGGVVDLPESVDDAALRLLVAVLRGGGRAEDHLAVRDGRLHGRRVVRASLPQSGSRSWTPHGTVLVTGAASPVGDQLVRWLADRGAERLVLAGACPGDDLLAAVEEAGASAVVCAQDAAALREALGDEPVTALVHAGTLTNFGSISEVAPEEFAETIAAKTALLAVLDEVLGDRAVEREVYCSSVAGIWGGAGMAAYAAGSAYLDALAEHHRARGRSCTSVAWTPWALPGGAVDDGYLRERGLRSLSADRAMRTWERVLAAGPVSVAVADVDWPVLSEGFAATRPTALFAELAGRGGQAEAEPDSGPTGEPAQRLAGLSPDEQQENLLELVANAVAEVLGHESAAEINVRRAFSELGLDSLNAMALRKRLSASTGLRLPASLVFDHPTVTALAQHLRARLVGDADQAAVRVVGAADESEPIAIVGIGCRFPGGIGSPEQLWRVLAEGANLTTGFPADRGWDIGRLYHPDPDNPGTSYVDKGGFLTDAADFDPGFFGITPREALAMDPQQRLMLETAWEAVERAGIDPDALRGTDTGVFVGMNGQSYMQLLAGEAERVDGYQGLGNSASVLSGRIAYTFGWEGPALTVDTACSSSLVGIHLAMQALRRGECSLALAGGVTVMSDPYTFVDFSTQRGLASDGRCKAFSARADGFALSEGVAALVLEPLSRARANGHQVLAVLRGSAVNQDGASNGLAAPNGPSQERVIRQALAASGVPAADVDVVEAHGTGTELGDPIEAGALIATYGQDRDRPLRLGSVKTNIGHTQAAAGAAGVIKVVLAMRHGMLPRSLHADELSPHIDWESGAVEVLREEVPWPAGERPRRAGVSSFGVSGTNAHVIVEEAPAEQEAARTERGPLPFVLSGRSEAVVAAQARALAEHLRDTPELGLTDAAWTLATGRARFDVRAAVLGDDRAGVCAELDALAEGRPSADAVAPVTSAPRKPVLVFPGQGAQWVGMARDLLESSEVFAESMSRCAEALSPHTDWKLLDVVRGDGGPDPHERVDVLQPVLFSIMVSLAELWRAHGVTPAAVVGHSQGEIAAAHVAGALSLEAAAKVVALRSQVLRELDDQGGMVSVGASRDELETVLARWDGRVAVAAVNGPGTSVVAGPTAELDEFFAEAEAREMKPRRIAVRYASHSPEVARIEDRLAAELGTITAVRGSVPLHSTVTGEVIDTSAMDASYWYRNLRRPVLFEQAVRGLVEQGFDTFVEVSPHPVLLMAVEETAEHAGAEVTCVPTLRREQSGPHEFLRNLLRAHVHGVGADLRPAVAGGRPAELPTYPFEHQRFWPRPHRPADVSALGVRGAEHPLLLAAVDVPGHGGAVFTGRLSTDEQPWLAEHVVGGRTLVPGSVLVDLALAAGEDVGLPVLEELVLQRPLVLAGAGALLRMSVGAPDESGRRTIDVHAAEDVADLADAQWSQHATGTLAQGVAAGPRDTEQWPPEDAVRIPLDDHYDGLAEQGYEYGPSFQALRAAWRKDDSVYAEVSIAADEEGYAFHPVLLDAVAQTLSLGALGEPGGGKLPFAWNTVTLHASGATSVRVVATPAGADAMALRVTDPAGHLVATVDSLVVRSTGEKWEQPEPRGGEGELHALDWGRLAEPGSTGRVVAADASDLDAVLRSGEPEPDAVLVRYEPEGDDPRAAARHGVLWAAALVRRWLEQEELPGATLVIATSGAVTVSDDDSVPEPGAAAMWGVIRCAQAESPDRFVLLDTDAEPGMLPAVPDNPQLALRGDDVFVPRLSPLAPSALTLPAGTQRLVPGDGAIDSVAFEPAPDVEQPLRAGEVRVDVRATGVNFRDVLLALGMYPQKADMGTEAAGVVTAVGPDVDAFAPGDRVLGLFQGAFAPIAVTDHRLLARVPDGWSDADAAAVPIAYTTAHYALHDLAGLRAGQSVLIHAAAGGVGMAAVALARRAGAEVLATAGPAKHGTLRALGLDDEHIASSRETGFARKFRERTGGRGVDVVLNSLTGELLDESADLLAEDGVFVEMGKTDLRDAGDFRGRYAPFDLGEAGDDRLGEILREVVGLLGAGELDRLPVSAWELGSAPAALQHMSRGRHVGKLVLTQPAPVDPDGTVLITGGTGTLGRLLARHLVTEHGVRHLLLVSRRGADAPGSDELRAEIEDLGASAEIAACDTADRDALSALLDGLPRPLTGVVHAAGVLADGLVTSIDEPAVEQVLRAKVDAAWNLHELTANTGLSFFVLFSSAASVLAGPGQGVYAAANESLNALAALRRTRGLPAKALGWGLWAQASEMTSGLGDRIARTGVAALPTERALALFDSALRRGGEVVFPLSINRSALRRAEFVPEVLRGMVRAKLRAAGQAEAAGPNVVDRLAGRSESDQVAGLAELVRSHAAAVSGYGSADQLPERKAFKDLGFDSLAAVELRNRLGTATGVRLPSTLVFDHPTPLAVAEHLRDRLFAASPAVDIGDRLDELEKALEALSAEDGHDDVGQRLESLLRRWNSRRADAPSTSAISEDASDDELFSMLDQRFGGGEDL