wanglab/gogpt-training-data huggingface dataset:
Protein: Disintegrin and metalloproteinase domain-containing protein 24 (ADAM 24) (EC 3.4.24.-) (Testase-1) (Q9R160)
Organism: Mus musculus (Mouse)
Function: Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.
Subcellular location: Membrane {ECO:0000269|PubMed:11309208}; Single-pass type I membrane protein {ECO:0000255}. Note=Localized to the equatorial region of the plasma membrane of cauda epididymal sperm. {ECO:0000269|PubMed:11309208}.
Interaction partners:
- Testis-specific expressed protein 55
- Serine protease 44
Sequence:
MVAMSEALVHARITLLQAWLRMLLFSSVWPPTWCAEYKGPPETVKPLRVIVSSKDMSLAGWMSYSLYFGGQRHIISMKSKNFLESRQLPVFTYNDQGVLFEDRPFVQNDCYYLGFVDGDLESMAALTTCFGGFQGILQINDTAYEIKPKSPSSTFEHLLYKIDSEKTQLRPMRCGLTDEEIAGQVRLQENGKSTRMQSIYGSWWSHGLYIKLALVIDHEQYLYRKKNTSLVIRDVLSIMQGINLFLLSVDINVVLLGLTIWTNGNPIPVQDIYALLPAFCTWKGTNLDSQIPYDIAHLFVNYTFSNYFGIAYVGTVCDKTFGCGIDSIAEDDFLTIGHIVAHEIGHNLGMSHDGILCTCGEESCLMSATMDSSQKLSNCSYEVLWAHMINKSCIHREPRPSDIFQLKVCGNGIVEEGEQCDCGSSENCRRNRCCMPSCTLRSKAKCDTGLCCNRKCQIQPSGTLCRARENECDLPEWCNGTSHECPEDLFVQDGTSCPGDGYCYEKRCNSHDVHCQRVFGQLAMKASDSCYKELNTRGDRFGNCGFINNEYVRCEISDILCGRIQCDKVGTLPILQNHYTIHWTHFNSVSCWSTDYHLGMKIADLGDIKDGTNCGPQHVCIARKCVNKPSWVNDCTPETCNMKGVCNNKQHCHCDVGWSPPNCQETGTGGSIDSGSPGNEVYEDEVVSKKDAPEKPNVIIWLLPIICVAVVLSVLFCLSGATKKSREAAASQPAEERVKPPYEGAEPSYETVKPPDEWANP
Protein: Receptor-type guanylate cyclase gcy-22 (EC 4.6.1.2) (Q9XTY1)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron. May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSFISKCFICLLFSTYFLPPVNSAVLQVGFLAANDNTTELAPFIGWGQVAGALGVAWSRIVEYGLLPGYETMNLTWVLTNCREADAVGSVINYAEGHAHVVLGPPCVRPAQVAGSVAKYLDFPLILWGPPFDSSLLNQFEYPTIASTTSSTLYQATSLIRLLEYYKWTEIALIYYVARSDLIPRCTPLISDFEGLVNNNDNLTITYRRQMSVITNTSYATALRNLKELARVVIVCLESDEARRNLMISISENGMDGDEYVYIMAESRRAGFASSFWNGTDGKNDLALRAARKFLVMDNQKYNDTTTFVQEVRAAFSRPPFSCPNCTNIDPTVSQVGPLGDALLLYAYALNRSIATGNPNPTGTEFCEVAKGMEFLGFTGKVIINQNSTRTPLFVVYNLDSTDKEMIVMQITEDLDDSKDPVASSVNYYITLVATPAQIWDTWGGTVPLSTPICGFTGTDCPKSFTDQYLAIILGCTAAALVLIIAVISTIVFLVRSKRQEEERLNQLWQVHFSSLVKPPQKNTMHSSRSLQSTVTTSTKVTINSKKDTERHSFYFLNNDSVVARKHNFRATFTKNDRAMFRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYEVKEQRDFLHTAPEHIRDTNLPITKEMDIYSFAIICSELITKKSAWDLENETFDIEELVYKIKKGGRSPPRPSLETEDEHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKSMNHNRSSNLMDHVFNVLEQYASNLEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLLTDDEIEAKENGESI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q586G9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase, putative
- Protein kinase, putative
- Splicing factor TSR1
- Cell division control protein, putative
- RNA-binding protein, putative
Sequence:
MPRPDRRAKYGRRAQNKITTGGGGAKRKSKPIAPHVEKDGIDINALLEEIERNDSPAEEKVPKETTKKSRRRRKAEKVEGLAVKPGTTVAQARMLASKMQQRHSASTNGPSQPAHQRSEEDEDEDDDDEEQDGSGEDYSDIANERPSEYRKGGYHPVVVGEVYNQRYRVVRKLGWGYFSTVWLVWDYVEKVFQAMKVQKSAKHYTEAAYDEIKLLGEIMTADPEKVRRCARLNDHFEQQGPNGKHVCMVFDVYGEDLLSLIERYKYHGVPLPIVKCISRQILIGLEHVHSLDIIHTDLKPENVLLSAPKHAIVSQMKRFKPPPLHDRPSLVKRDPKTMTKSQRRRYYKKLRAAGKGKDSAEGNEEQNDDEDIAREVHVDPNEAAPQQSEKEPLSETDSEWEVERLHHVVLADFGNSCWTYRQFTDEVQTRQYRSPEVILGYPYSTSIDLWSAACMIFELITGEFLFDPRKGSDYSRDEDHLALISELLGVLPVSMRLGDGKYRAQYYNSRGELRSIKDLNFWGLEDVLYRKHKFTRKKAKEIAEFLLPMLELEPHNRATATDMLNNFQHFFEVQEDDYAPLCFVPSSDDHRGGERSSGNMEESEFSDTFEETDDYDRSRRLDRTYDAMEDSLSRQDEETARYLAGHSLLNEASLAKRGLTILDIQAVLSGQQLEDEERQAAATEIIRLLSEEADDSSDGHCADREDGDSNSSVDESDSSCTND
Protein: Bacterial non-heme ferritin (EC 1.16.3.2) (Q9ZLI1)
Organism: Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Function: Iron-storage protein.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MLSKDIIKLLNEQVNKEMNSSNLYMSMSSWCYTHSLDGAGLFLFDHAAEEYEHAKKLIIFLNENNVPVQLTSISAPEHKFEGLTQIFQKAYEHEQHISESINNIVDHAIKSKDHATFNFLQWYVAEQHEEEVLFKDILDKIELIGNENHGLYLADQYVKGIAKSRKS
Protein: GH09231p (Male-specific RNA 98Ca) (Q9VAW8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cytosol aminopeptidase
- Cytosol aminopeptidase
- Male-specific sperm protein Mst84Dc
- Cytosol aminopeptidase
- AT18965p
- Male-specific sperm protein Mst84Da
- 10 kDa heat shock protein, mitochondrial
- Cytosol aminopeptidase
- AT20732p
- GEO12122p1
Sequence:
MCSPCGPCSPCDPCCGPFECSPKCYNAAQLEALPQCAPRIPPPFPKCITVQQPPRMICKKRVVFTEKIVPEPMVVNRCRQITIPKVVDATRVIKVPKLIWVSQMVREPRVIYYPSMIPDPYVVCYPKRVCEPREVCQSILCQPKPQTIDIPPPREYCCYPNGPINYKPSAACPPCPIGPCAPGGPCCPLPCFSTNQYPVAEGRCGPCGPCGPGCGPCGPRCGPCGPGPCGPCGPRCGPGGPCAVPNCGPCGLTMPSGPFVPAPCGPCAPCGPCGPLGNSPCGPCGPCGPCSPPCPYESPECGPCYPCAPTPWNTHCGPVGPCGPQVPCGPSGPC
Protein: ABC-type dipeptide transporter (EC 7.4.2.9) (Q880R1)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004417}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004417}.
Interaction partners:
- Nickel ABC transporter, permease protein, putative
- Nickel ABC transporter, permease protein
- Nickel ABC transporter, periplasmic nickel-binding protein, putative
- Dipeptide ABC transporter, permease protein DppC, putative
- Peptide ABC transporter, permease protein
- Peptide ABC transporter, permease protein
- Peptide ABC transporter, permease protein
- Peptide ABC transporter, permease protein
- Peptide ABC transporter, permease protein
Sequence:
MTDSPPLIDIRHLSVAYRFDGQTNQAVRNVSFQVASGETVAIVGESGSGKSTLANAILGLLPDNARINGGELHIDGHDLSHASERERRRVRGSVIGLVPQDPMVSLNPTLRIGRQIAEALILANGRRYPAVDADVLELLQQVGLDKPVLRARQYPHELSGGMRQRVLIAIALAGNPRLIIADEPTSALDVTVQRKILDHLQRLVAERGISLLIITHDLGVAADRADRVLVMKSGELVEQGAPQHILINPAHAYTRALIAAAPAFGQRKSPAAPRVVSSNDTPLLTLSNIGKTYRLPYVKGEDADFQALHDVNFKVYPGQTLAIVGESGSGKSTALRIALGLEKPTCGRVLLEGRDVTDLGWREFRPLRRRIQLVQQNPFAALDPHFTLFESIVEPLVSFGLLKGRELEQAARRLIERVHLPVAYLDRLPRELSGGQRQRVAIARALALKPDLLLLDEPVSALDVSVQAQILDLLVELQAESGIAYVLVSHDLAVVASVAHQVLVLKHGKTIEHGPASDVFERPEAAYTQELIAAIPGRRLELQAAAQH
Protein: Vexin (Q8TAG6)
Organism: Homo sapiens (Human)
Function: Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8BG31}. Nucleus {ECO:0000250|UniProtKB:Q8BG31}. Note=Nuclear localization is essential for its function in neurogenesis. {ECO:0000250|UniProtKB:Q8BG31}.
Interaction partners:
Sequence:
MMHQIYSCSDENIEVFTTVIPSKVSSPARRRAKSSQHLLTKNVVIESDLYTHQPLELLPHRGDRRDPGDRRRFGRLQTARPPTAHPAKASARPVGISEPKTSNLCGNRAYGKSLIPPVPRISVKTSASASLEATAMGTEKGAVLMRGSRHLKKMTEEYPALPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAFEAD
Protein: Nucleolar pre-ribosomal-associated protein 1 (URB1 ribosome biogenesis homolog) (A0A0R4ILM9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MATKRENEENITESVTKAKKGKTDESEFSGTVFKSMLKDSSEAQKGLATFIRVAKTLPCAELYDVVEGYIKISAECSEIFALLDEEKPEKEMMLIFQCLEMILLRTASDLSQFSMVGANIVRRIVSKHMTLLQSSLYSKNYRFVRQCLSLLSALVSQSADAARDVFGQMQFGKDLCQLARKRDKSGKSDVRMAFIQFVLSFLMSGDNTTIGQILDTKELSEILNSGLKEDRLSIINLILSTLQTKVVQNKTITKTQKVRFFSASILAQIASLYRWNGIVDVSVDEEEKVEEGGKHIMRELVHNFLMDLCCSRKHGISFHDPSLGTAGKVGNLVLLQFLVRLKQATEDEMVAELVVNVLKGSPDILNRYFKETQCSFAPRNNKTWQDNISLLKKIYEVQPVVSKAFQMNEMVPFPRLLSMVLVTSLPPVCNKVFFTQGLNVHSLVVQHTTLSLLAFILKRAQQNIEYCLDRTVWETSDIYSPAMMEEFVQLYREALSKILPDMVSIVSIWQLHSKEKEDAAKMKNRKQKQSQEHSQQDDPHLILVKALLLQVMCLYQKVVPHLVTQSRFDFSKLLKGIVTESGMTQEVPPVLQYQILQLALELPASKFSWFRVQEMANPDFEKGEKSVIYLLLKMFVSSNNSYLKTSSRMLVLKVLRDSGVFEHTWKELELWLDHLTMLGLSQQETVIQFLDHVLTRVVCNSHVYTDKAASMVQEAANLQANLNGQDGDEASIPISHIDDVLDMVDVIVESSEGDIEEIGPSLTEDIILQTFPFSAVVPAVLEARNKLPDSFKDAKGVLYEYMAAVLCDVLHCQRDPLALCLTLQHYDKELSTSDAASTPHASVVSFYHYYSQWLPKNTHHTLFISESFTDGGSHADFTALLKTSFTEGANAFLRTSFKEALQEALATLTVSRIPVAVNQVLLYLRNYVLNFNMLLKETAAEVLSSLMMVLNALILKLLSSDTHTPVESESAGQHDEDALFLDTNQVPAENTDKQQIVLAVLKSVFKHPAVEQWFLALELSSFPPHSLNPVRLKQLCVCLTEMTLLLLESSADTLRDLDALELISTYLTSPQRAVLRELQEMKSNCPKKESLSVRALLALQEYIEPSSFKEVVSTLLLLPQKHLLAPENQLSVYGRTVQKLLSDSLKRSSAVSSSCVTLSPAHLQGLAALFTSCQCVQLEDFLLQVLSREPGTAKLIQTDILLHCIQRESPSAQDIGVVLLENCSTHVLSFELWCLDPSNQKQISVQNGSFLSLLNSYLKRSTADDPTRPKDVQKSVLKVLKNALMAELWHTVQQGEAGVRTALHVEVLSSLIRLAAVNSDLIQLIKDLPAILQKPDTYERWKLADSISEKLCDDSEELHQWRKSLLSAALVWLTAVYKKQKEPQSNHEESMLTRLRSLLLGQIFPENMTASDWNAFVKSGLKHRYHDCNFLETLNSLVEVIYDTPDTPKEMLPVATIHMMTTTHSLFLPTMLAIDTDSLRLTKESLVSLLLTLVRKSPEVCNVNHFLVLLGAYEASLSTTDQKLLLVLQEYEKNNISLAEFQFVLWGPAAVEHHKTRKSLGPSLWQKPTSEHLLSLLSADRMLNTVTHFPQRRYIIPQVNKTMIYIQEGKRSVDLSSLYDPCFLLPLFSFILQPECAVDCLKFVSCQALGVTMAALSSYDSKVRAAAYQVLGSFYQHLEGARFKEKRQLLYLLDTVKNGIQKQNLRVPFVHVAYIAKVAQQILRPEEHMYMVVSRFLLGTQFLDLKRVPDFFKLFYSFELEHKLEREWILSVLEEGVWDQSCYELCEMQRIYQTLLAFASTSLCDQATQIQIVRVLRQTARVNRAAYILTKEHGVLTWIVQLIEKRYVDSKLLSSVIELLHALWFTNLGDKESKAEASSTSSEQPQTSGKCLPLPIINEFLCTLLTVIRHLRSGVSGLQLQQFLHTLSSVLVHCGTAMNAYKEAGWLTLHPHKLSCSEVLSLLQRWTALSHDASLASALQTVGNKHKVKELMGSGREKGQGKCHSTKHAPMEKQTENAEVLDQAVLDECKPHLRNILLHWEPKEKELSTSTSQTVSDKPASSGLSNTTACVIFKWALKTLTESRFDDKCTLALLKWTHSTIMPHRSITDAVLSDEGVRKDLLRLFHLTAQEGTLNTLQLFSTVMLHLLEAHRDRLNAGHQTLIQTCLLTNTDDEAKKETGLNLLSLYLYELWSEAQSPDLLLTHARLICSGTSSKKPKSHILHICRDILAAFHS
Protein: Epididymis secretory sperm binding protein (A0A384MTJ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
Protein: Cathepsin J (EC 3.4.22.-) (Cathepsin L-related protein) (Cathepsin P) (Catlrp-p) (Q63088)
Organism: Rattus norvegicus (Rat)
Subcellular location: Lysosome {ECO:0000305}.
Interaction partners:
Sequence:
MTPAVFLVILCFGVASGAPARDPNLDAEWQDWKTKYAKSYSPVEEELKRAVWEENLKMIQLHNKENGLGKNGFTMEMNAFADTTGEEFRKSLSDILIPAAVTNPSAQKQVSIGLPNFKDWRKEGYVTPVRNQGKCGSCWAFAAVGAIEGQMFSKTGNLTPLSVQNLLDCSKSEGNNGCRWGTAHQAFNYVLKNKGLEAEATYPYEGKDGPCRYHSENASANITGFVNLPPNELYLWVAVASIGPVSAAIDASHDSFRFYSGGVYHEPNCSSYVVNHAVLVVGYGFEGNETDGNNYWLIKNSWGEEWGINGFMKIAKDRNNHCGIASQASFPDIF
Protein: Troponin I2, fast skeletal type (A0A060W984)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Troponin T, slow skeletal muscle
- Troponin T type 2b
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Troponin T type 3a
- Troponin T2d, cardiac
- Troponin T2e, cardiac
- Troponin T2e, cardiac
Sequence:
MRTIYTLLKKRKGTLKQHNVTPMSPLLHQSVSCPPLLIGSEAHIPPSCLIFIFIKIIMNMYHAALWSSSPSPDDNRHNSTNDTTLLLNSLETIGKRMTSSRKHHLKSLMLQIAATLIEEEKKQIKEEKANFMAKISALDLSGDQAALMEMLKKLSQTIDKVDEERYDAEAKVKKTEKEIEDLKMKVIEVQGIKKPALKKVRMSADAMLAALLGTKHKASMDFRANLKEVKKEVKEEEEVGDWRKNVDEQAGMDGRKKKFEST
Protein: Protein translocase subunit SecE (P0AG96)
Organism: Escherichia coli (strain K12)
Function: Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true it also results in FtsH-mediated degradation of SecY.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00422, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00422, ECO:0000269|PubMed:15919996}.
Interaction partners:
- Protein translocase subunit SecF
- Protein translocase subunit SecD
- Transcription termination/antitermination protein NusG
- Membrane protein insertase YidC
- Large ribosomal subunit protein uL11
- Protein translocase subunit SecY
- Protein-export membrane protein SecG
- Protein translocase subunit SecA
- Signal recognition particle receptor FtsY
- Signal recognition particle protein
Sequence:
MSANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVALLTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRLVSFITGLRF
Protein: Glycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (Q9JL55)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol. Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10760272, ECO:0000269|PubMed:12576545}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10760272, ECO:0000269|PubMed:12576545}; Multi-pass membrane protein {ECO:0000255}. Note=Perinuclear vesicles and cell membrane. {ECO:0000305|PubMed:12576545}.
Interaction partners:
- 
- N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
- Monoglyceride lipase
- Fatty-acid amide hydrolase 1
- protein-tyrosine-phosphatase
- Lysophosphatidylserine lipase ABHD12
- N-acylethanolamine-hydrolyzing acid amidase
- Monoacylglycerol lipase ABHD6
Sequence:
MWLWEDQGGLLGPFSFVLVLLLVVTRSPFNACVLTGSLYLLLRFFSFEPVPSRRALQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGVPVLMHDNTVDRTTDGSGRLCDLTFEQVRKLNPAANHRLRNEFPDERIPTLREAVTECLCHNLTIFFDVKGHADMASAALKNIYMEFPQLYNNSMVCSFLPEVIYKMRQTDQKVITALTHRPWSLSHTGDGKPRYSVFWKQSVFVVLDILLDWSMHNVLWYLCGISAFLMQKDFVSPDYLKKWSAKGIQVVSWTVNTFDEKNYYESHLGSSYITDSMLEDCAPHF
Protein: Structural polyprotein (p130) (Q1H8W5)
Organism: Chikungunya virus (CHIKV)
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004598}. Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004402}. Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion membrane {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004385}. Virion membrane {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004563}.
Interaction partners:
Sequence:
MEFIPTQTFYNRRYQPRPWTPRPTIQVIRPRPRPQRQAGQLAQLISAVNKLTMRAVPQQKPRRNRKNKKQKQKQQAPQNNTNQKKQPPKKKPAQKKKKPGRRERMCMKIENDCIFEVKHEGKVTGYACLVGDKVMKPAHVKGTIDNADLAKLAFKRSSKYDLECAQIPVHMKSDASKFTHEKPEGYYNWHHGAVQYSGGRFTIPTGAGKPGDSGRPIFDNKGRVVAIVLGGANEGARTALSVVTWNKDIVTKITPEGAEEWSLAIPVMCLLANTTFPCSQPPCTPCCYEKEPEETLRMLEDNVMRPGYYQLLQASLTCSPHRQRRSTKDNFNVYKATRPYLAHCPDCGEGHSCHSPVALERIRNEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDNHMPADAERAGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHSCTHPFHHDPPVIGREKFHSRPQHGKELPCSTYVQSTAATTEEIEVHMPPDTPDRTLMSQQSGNVKITVNGQTVRYKCNCGGSNEGLTTTDKVINNCKVDQCHAAVTNHKKWQYNSPLVPRNAELGDRKGKIHIPFPLANVTCRVPKARNPTVTYGKNQVIMLLYPDHPTLLSYRNMGEEPNYQEEWVMHKKEVVLTVPTEGLEVTWGNNEPYKYWPQLSTNGTAHGHPHEIILYYYELYPTMTVVVVSVATFILLSMVGMAAGMCMCARRRCITPYELTPGATVPFLLSLICCIRTAKAATYQEAAIYLWNEQQPLFWLQALIPLAALIVLCNCLRLLPCCCKTLAFLAVMSVGAHTVSAYEHVTVIPNTVGVPYKTLVNRPGYSPMVLEMELLSVTLEPTLSLDYITCEYKTVIPSPYVKCCGTAECKDKNLPDYSCKVFTGVYPFMWGGAYCFCDAENTQLSEAHVEKSESCKTEFASAYRAHTASASAKLRVLYQGNNITVTAYANGDHAVTVKDAKFIVGPMSSAWTPFDNKIVVYKGDVYNMDYPPFGAGRPGQFGDIQSRTPESKDVYANTQLVLQRPAAGTVHVPYSQAPSGFKYWLKERGASLQHTAPFGCQIATNPVRAVNCAVGNMPISIDIPEAAFTRVVDAPSLTDMSCEVPACTHSSDFGGVAIIKYAASKKGKCAVHSMTNAVTIREAEIEVEGNSQLQISFSTALASAEFRVQVCSTQVHCAAECHPPKDHIVNYPASHTTLGVQDISATAMSWVQKITGGVGLVVAVAALILIVVLCVSFSRH
Protein: Apoptosis inducing factor mitochondria associated 1 (E9PMA0)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
Protein: Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein) (O14682)
Organism: Homo sapiens (Human)
Function: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:19424503}. Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19424503}.
Interaction partners:
- Cullin-3
- Kelch-like protein 25
- Kelch-like protein 9
- E3 ubiquitin-protein ligase RBX1
- Kelch-like protein 13
- Kelch-like ECH-associated protein 1
- Kelch repeat and BTB domain-containing protein 8
- Gigaxonin
- Kelch-like protein 41
- Kelch-like protein 7
Sequence:
MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS
Protein: Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I) (P62966)
Organism: Rattus norvegicus (Rat)
Function: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Subcellular location: Cytoplasm.
Interaction partners:
- Cytochrome P450 26A1
- Cytochrome P450 26B1
- Cytochrome P450, family 26, subfamily C, polypeptide 1
- Retinoic acid receptor beta
Sequence:
MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLPTWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE
Protein: Protoheme IX farnesyltransferase (EC 2.5.1.141) (Heme B farnesyltransferase) (Heme O synthase) (P9WFR7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00154}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00154}.
Interaction partners:
- Probable cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Probable cytochrome c oxidase subunit 3
- Probable unidentified antibiotic-transport integral membrane ABC transporter
- Coproporphyrin III ferrochelatase
- Cytochrome bc1 complex cytochrome b subunit
- Possible cytochrome C-type biogenesis protein CcsA
- Probable cytochrome c oxidase polypeptide 4
- Uncharacterized SURF1-like protein Rv2235
- Cytochrome bc1 complex cytochrome c subunit
Sequence:
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH
Protein: Transmembrane protein (Q9T069)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL23m
- Signal transducer, putative
- Uncharacterized protein F28B23.5
- Heat shock 70 kDa protein 9, mitochondrial
- Protein-lysine N-methyltransferase At1g66680
- U-box domain-containing protein 8
- AT4g21620/F17L22_80
- Paraxanthine methyltransferase 2
- Cytochrome c oxidase subunit 6a, mitochondrial
Sequence:
MVRTPRRGQRSKGIKVKHCIQLTLLLGVGIWLIYQMKHSHEKKAEFEGTSKIVVDDIDNTVVNLGRKDLRPRIEETKDVKDEVEDEEGSKNEGGGDVSTDKENGDEIVEREEEEKAVEENNEKEAEGTGNEEGNEDSNNGESEKVVDESEGGNEISNEEAREINYKGDDASSEVMHGTEEKSNEKVEVEGESKSNSTENVSVHEDESGPKNEVLEGSVIKEVSLNTTENGSDDGEQQETKSELDSKTGEKGFSDSNGELPETNLSTSNATETTESSGSDESGSSGKSTGYQQTKNEEDEKEKVQSSEEESKVKESGKNEKDASSSQDESKEEKPERKKKEESSSQGEGKEEEPEKREKEDSSSQEESKEEEPENKEKEASSSQEENEIKETEIKEKEESSSQEGNENKETEKKSSESQRKENTNSEKKIEQVESTDSSNTQKGDEQKTDESKRESGNDTSNKETEDDSSKTESEKKEENNRNGETEETQNEQEQTKSALEISHTQDVKDARTDLETLPETSNGLISDKVAAE
Protein: RNA polymerase I-specific transcription initiation factor rrn7 (Q9UST5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of RNA polymerase I core factor complex (CF) that acts as a sua7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds HomolD box in rDNA promoters and plays a role in Pol I recruitment.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor rrn11
- Uncharacterized protein C3B8.11
- Elongation factor 3
- mRNA export factor elf1
- TATA-box-binding protein
- Small ribosomal subunit protein eS25B
- RNA polymerase I-specific transcription initiation factor rrn3
- RNA polymerase I-specific transcription initiation factor rrn5
- RNA polymerase I-specific transcription initiation factor RRN9 homolog
- Small ribosomal subunit protein uS8A
Sequence:
MEGNWFEGPPCSVRNCKSTWYFKNAGQTFCRRGHAQHGIEIAQDDEPGAGTFYQTRKRKVVRNHLDTGDEDEIVYGTAGRSLYLQAFQIILQLQCQALTTKLGFDQRIEGMIRDLWALYLSLSYESFTSSFLSLNQNSTQSESSDSDFDLIDPESQPGADPSSRKTKETSQSHSISYPRLLYSSAFIYVACLLLRLPLTIHKLEVLIRKNIIPYYRAYKQIPLKIFKRLQKNYVRMLIPFHYPTYQRIQSAVLTLVDVLVSKYELKVPPPNEPLILFELINSFFFPLEIFIPASRLLNLVHSQISLQGTSSDNYQSKIRSAQSIHEKLSDAEVMLLATILVAANVCYGFDDAQTRNSKYKDSMFTVKTNWNMWLSQVQKINEKEKDKFYEIDEQSILTLNNSEMDKYFQWYEKEFVEENNPNNIPEGILNVFPILSKDSHLQENQPTDILTDESVIAEDVKLEQVFKPVGIKESDKMDFSRRKDAYISMLPFSPNTENTAHRVTIMVAKLYNIKLDSLIAAIRYVESCLKTGIHNQD
Protein: DNA mismatch repair protein S5 domain-containing protein (Q9XU10)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA mismatch repair proteins mutS family domain-containing protein
- Mismatch repair endonuclease PMS2
- DNA mismatch repair protein
- Exonuclease 1
- Fanconi-associated nuclease 1 homolog
- MutS protein homolog him-14
- MutS protein homolog 5
- RecQ-like DNA helicase blm-1
- Helicase ATP-binding domain-containing protein
- Crossover junction endonuclease MUS81
Sequence:
MGLIQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGATEIMVNMQNGGLKLLQVSDNGKGIEREDFALVCERFATSKLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKRADAKCAYQANFLDGKMTADTKPAAGKNGTCITATDLFYNLPTRRNKMTTHGEEAKMVNDTLLRFAIHRPDVSFALRQNQAGDFRTKGDGNFRDVVCNLLGRDVADTILPLSLNSTRLKFTFTGHISKPIASATAAIAQNRKTSRSFFSVFINGRSVRCDILKHPIDEVLGARQLHAQFCALHLQIDETRIDVNVHPTKNSVIFLEKEEIIEEIRAYFEKVIGEIFGFEALDVEKPEEEQPDIENLVMIPMSQSLKSIEAIRKPDTKPEFKSSPSAWKSDKKRVDYMEVRTDAKERKIDEFVTRGGAVGPTTSNDDIFGGSGILKRARTEDSTGGEKEPEDLNTDFDDVSMVSLVSTADGRRLNESQDLGEDDDVDFEYGKTHREFHFESIEVLRKEIIANSSQSLREMFKTSTFVGSINVKQVLIQFGTSLYHLDFSTVLREFFYQISVFSFGNYGSYRLDEEPPAIIEILELLGELSTREPNYAAFEVFANVENRFAAEKLLAEHADLLHDYFAIKLDQLENGRLHITEIPSLVHYFVPQLEKLPFLIATLVLNVDYDDEQNTFRTICRAIGDLFTLDTNFITLDKKISAFSATPWKTLIKEVLMPLVKRKFIPPEHFKQAGVIRQLADSHDLYKVFERCGT