wanglab/gogpt-training-data huggingface dataset:
Protein: BRCA2-interacting transcriptional repressor EMSY (Q7Z589)
Organism: Homo sapiens (Human)
Function: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors.
Subcellular location: Nucleus {ECO:0000269|PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
Interaction partners:
- Breast cancer type 2 susceptibility protein
- Chromobox protein homolog 1
- PHD finger protein 12
- Mortality factor 4-like protein 1
- Zinc finger MYND domain-containing protein 11
- GATA zinc finger domain-containing protein 1
- Paired amphipathic helix protein Sin3b
- Lysine-specific demethylase 5A
- Breast cancer type 1 susceptibility protein
- Histone deacetylase 1
Sequence:
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHNMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAIQHNASLPVPAETGSKEVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKPPVVITASQSSLVSNSSSGSSSSTPSPIPNTVAVTAVVSSTPSVVMSTVAQGVSTSAIKMASTRLPSPKSLVSAPTQILAQFPKQHQQSPKQQLYQVQQQTQQQVAQPSPVSHQQQPQQSPLPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSIGRMAATPGAATYVKTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTIQTVPTGAKPAILTATRPITKMIVTQPKGIGSTVQPAAKIIPTKIVYGQQGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVAEAGNSSIQEGKEEPQNYTDSSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTERTDEGTEVAFPLLVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSAKQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLPQMPQLSIRHQKLTPLQQEQAQPKPDVQHTQHPMVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMSLPASSEKQTASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAVSDILKMSLMEAQIDTNVEHMIVDPPKKALATSMLTGEAGSLPSTHMVVAGMANSTPQQQKCRESCSSPSTVGSSLTTRKIDPPAVPATGQFMRIQNVGQKKAEESPAEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDEETAMEQDIDSSTEDGTEPSPSQSSAERS
Protein: Heat stress transcription factor C-1b (Heat stress transcription factor 11) (rHsf11) (Heat stress transcription factor 3) (OsHsf-03) (Q942D6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Heat shock protein 81-2
- Os06g0274000 protein.
Sequence:
MMGGECKVHQLQAAGDGGPGAVAPFVAKTFHMVSDPSTNAVVRWGGAGNTFLVLDPAAFSDFLLPSYFKHRNFASFVRQLNTYGFRKVDPDRWEFAHESFLRGQAQLLPRIVRKKKKGGAAPGCRELCEEGEEVRGTIEAVQRLREEQRGMEEELQAMDQRLRAAESRPGQMMAFLAKLADEPGVVLRAMLAKKEELAAAGNNGSDPCKRRRIGADTGRGGVATGGDAAEMAQSRGTVPFPFSVLGQVFY
Protein: Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) (P54874)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). Hcs1 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase eg10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases erg13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hcs1 (Probable).
Interaction partners:
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Acetyl-CoA acetyltransferase
- Squalene epoxidase erg1
- Squalene synthase
- Mevalonate kinase
- Isopentenyl-diphosphate delta-isomerase
- Farnesyl pyrophosphate synthase
- C-4 methylsterol oxidase erg25
- Lanosterol 14-alpha demethylase erg11
- Lanosterol synthase erg7
Sequence:
MSFDRKDIGIKGLVLYTPNQYVEQAALEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALSQLIKRYQIDISKIGRLEVGTETIIDKSKSVKSVLMQLFGDNHNVEGIDCVNACYGGVNALFNTIDWIESSAWDGRDGIVVAGDIALYAKGNARPTGGAGCVALLVGPNAPIVFEPGLRGTYMQHAYDFYKPDLTSEYPYVDGHFSLECYVKALDGAYANYNVRDVAKNGKSQGLGLDRFDYCIFHAPTCKQVQKAYARLLYTDSAAEPSNPELEGVRELLSTLDAKKSLTDKALEKGLMAITKERFNKRVSPSVYAPTNCGNMYTASIFSCLTALLSRVPADELKGKRVGAYSYGSGLAASFFSFVVKGDVSEIAKKTNLVNDLDNRHCLTPTQYEEAIELRHQAHLKKNFTPKGSIERLRSGTYYLTGIDDMFRRSYSVKP
Protein: Protein ZDS2 (P54786)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways.
Interaction partners:
- Protein phosphatase PP2A regulatory subunit B
- Protein phosphatase PP2A regulatory subunit A
- Protein ZDS1
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Protein kinase C-like 1
- GTPase-interacting component 1
- BEM1-interacting protein 1
- Proteasome activator BLM10
- Serine/threonine-protein kinase CLA4
Sequence:
MVLMEDMQNKDGHNTVENSSGGTDSNNNIQMRRMRKTQLSKKELFEKRKSDVLIAAKSLDTEIQNVKNLKRLSIGSMDLVIDPELEFKVNSRNSYSSDSSKESLQESLHEENIIRSEQKEEQGSEDNDAYEEGDATNVDDSIDITQTEYLHDEETLEKEKIIRNASSSTSSSARVTSRNRRLSGVKTLAHDVVLDVENDHDSKMVDLTQNLLWVPADQHPNVKPENYLELIQDTLQNIQISTNQDIDENKLELGNNHVISNRKRTGSVVRRPSRLKTSYTKFDDEPPLADKPQEGEIQVDKRISSSDIKTIRSVSLKEITEELTKISNNAGLTDSDAVTLARSLSMSGSFTNESLHLNGNHTENDNEFASNMFNETGLTIPERSSLRRSKFNTYKIRLEGSSLPQAVKLNSLMNIQTNDNRRSASSPASYTQVPQEQASLNDFHEIFDHYRRTSTDWSTENEKYVDSTNYYSDEEDLTHASISQESSLLSTDSSNNSVLIKPHNTGSMISEKLDQHVSSSEKSNTNNSEANHGWSWLNSSNGSLNANEQTYQQLTDDEDDEECVDNEKADFVNLSVSRRAKSTKRASERINHSKNRHSPIFQIHSEEAKSVVITPSVVSSSESQPSKPTAPAVVEKKVELPTDTQASTHKKNSLEKRLAKLFKRKQHNGTCKSDVKVIKKSVKKELKKKASHSSLSKFRKSPKKKPQEAEVERPSSPTKTITTEDIDTASVIEPEVRSSNASTLLPDSHTSHSSEFVVETISELDGDDSFDISGGDVNYDVEVHSSISRDTTAGLEEDIGAEREDNTSPTAPQISTLPPRKLTFEDVVKPDYSNAPIKFTDSAFGFPLPMITNSTVIMFDHRLGINVERAIYRLSHLKLSDPGRELRQQVLLSNFMYSYLNLVNHTLYMEQVGTGDIAFNGDSALGMMDKNDSDGTILIPDI
Protein: Probable gamma-glutamyl hydrolase 3 (AtGGH3) (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase) (Q9ZV85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role on folate stability and intracellular folate content (By similarity).
Subcellular location: Vacuole {ECO:0000250}. Secreted, extracellular space {ECO:0000250}. Secreted, cell wall {ECO:0000250}. Note=Extracellular or cell-wall bound.
Interaction partners:
- Folylpolyglutamate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Folylpolyglutamate synthase
- Folylpolyglutamate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
- Bifunctional dihydrofolate reductase-thymidylate synthase 1
- Probable ubiquitin-conjugating enzyme E2 24
- Gamma-glutamyl hydrolase 2
- Gamma-glutamyl hydrolase 1
- Phosphate transporter PHO1
Sequence:
MWRFCFFLSLLFFDVSAVKSAESIFLPSQIGVEDSRVFESLSLSPVCSAADPNLNYKPVIGILTHPGEGRWDARLHSLKNYAYATNISYIAASYVKLAETGGARVIPLIYNEPEEILFQKLELVNGVIFTGGWAKTGLYYDVVEKIFNKVMEKNDAGEHFPVYAMCLGFEILSMIISQNRDILERFNSVNYASSLQFFKNVNIEATVFQRFPPELLKKLSADCLVMQNHYFGISPDNFQGNPYLSSFFNIVTTSADKDSKTFVSTIRSKRYPVTAFQWHPEKNAFEWGSSEIPHSEDAIQVTQHAANYLVSEARKSMNRPSSEKVLSNLIYNYKPTYSGYKGSGDDEVYIFT
Protein: Zinc finger protein lsy-2 (Laterally symmetric 2) (Q9N5S3)
Organism: Caenorhabditis elegans
Function: Involved in transcriptional regulation (By similarity). Required to specify left-right asymmetry of the ASE gustatory neurons, probably acting upstream of microRNA lsy-6. Involved in maintaining the distinction between somatic and germ cells, perhaps acting by repressing germ cell-specific genes in somatic cells.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:16291785}. Note=Localization in nuclear speckles/punctae is dynamic, appearing to move. {ECO:0000269|PubMed:16291785}.
Interaction partners:
- C2H2-type domain-containing protein
- Nuclear Hormone Receptor family
- BZIP domain-containing protein
Sequence:
MLTRRNAKQSQRNSADQSLSEFNSSSMTHGSNQSVYHHNQHMDDSEMMMDEQDYSQYQMGFPEEDEMVEGMMTPRAVHQCNVCNKIFVSYKGLQQHAVIHTDQKPFRCDICSKSFRFKSNLFEHRSVHTGFTPHACPYCGKTCRLKGNLKKHLRTHVTTKEELEAAWRPFASNRRPPADIPDDAIVLRGAGGPYYTPPPRPKKKKLGLGEPEHWVDKLRRGDLLPQVELEDKIRRLEDTIFNNMSLERWGNLFEIAKSIAFETHDCPVCKSQFMTRMDCVSHHTLEHENHREGLEFFCEKCYRPFADEASYNQHMSYHTRVSSLIETGEIVPQPADPEILVPTNDEFQMLFGANFGQQMMEPQLI
Protein: Host-modulation protein 11K (Host-modulation protein of 11 kDa) (P0DJZ0)
Organism: Human parvovirus B19 (strain HV) (HPV B19)
Function: Enhances viral DNA replication and virion release. Plays a role in viral infectivity. Induces apoptosis of primary erythroid progenitor cells.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:19861680, ECO:0000269|PubMed:30282717}.
Interaction partners:
Sequence:
MQNNTTGMDTKSLKNCGQPKAVCTHCKHSPPCPQPGCVTKRPPVPPRLYLPPPVPIRQPNTKDIDNVEFKYLTRYEQHVIRMLRLCNMYQNLEK
Protein: Zinc finger protein 225 (Q9UK10)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 234
Sequence:
MTTLKEAVTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVGHQSLHRDTFHFLKEEKFWMMETATQREGNLGGKIQMEMETVSESGTHEGLFSHQTWEQISSDLTRFQDSMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPSEGRTCKKSFSDVSVLDLHQQLQSREKSHTCDECGKSFCYSSALRIHQRVHMGEKLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKCEQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFIHDSQLQEHQRIHTGEKPFKCDICCKSFRSRANLNRHSMVHMREKPFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECGKRFIYRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSGETTFKCEECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKGYKRRLDLDFHQRVHRGEKPYNCKECGKSFGWASCLLNHQRIHSGEKPFKCEECGKRFTQNSQLYTHRRVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECGKGFNSKFNLDMHQRVHTGERPYNCKECGKSFSRASSILNHKRLHGDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFRWASTHLTHQRLHSREKLLQCEDCGKSIVHSSCLKDQQRDQSGEKTSKCEDCGKRYKRRLNLDTLLSLFLNDT
Protein: Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) (Q8WTY4)
Organism: Mus musculus (Mouse)
Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03115}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115}.
Interaction partners:
- Glutaredoxin-3
- BolA-like protein 2
- NADPH dependent diflavin oxidoreductase 1
- NADPH-dependent diflavin oxidoreductase 1
- BolA-like protein 1
- MMS19 nucleotide excision repair protein homolog
- Cytosolic iron-sulfur assembly component 3
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
Sequence:
MEEFGISPGQLVAVFWDKSSPEEALKKLVARLQELTGSEGQVFMENVTQLLQSSHKESSFDVILSGVVPGSTSLHSAEVLAEMARILRPGGCLFLKEPVETAEVNNDKMKTASKLCSALTLSGLVEIKELQREALSPEEVQSVQEHLGYHSDSLRSVRVTGKKPNFEVGSSSQLKLPNKKSSSVKPVVDPAAAKLWTLSANDMEDDSVDLIDSDELLDPEDLKRPDPASLKAPSCGEGKKRKACKNCTCGLAEELEREQSKAQSSQPKSACGNCYLGDAFRCANCPYLGMPAFKPGEQVLLSNSNLQDA
Protein: Acyl-lipid (8-3)-desaturase (EC 1.14.19.30) (AN Delta(5)-fatty-acid desaturase) (Acyl-lipid 5-desaturase) (Delta-5 desaturase) (PPDES5) (A9SIZ6)
Organism: Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
Function: Fatty acid desaturase that introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta(8) double bond.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAPHSADTAGLVPSDELRLRTSNSKGPEQEQTLKKYTLEDVSRHNTPADCWLVIWGKVYDVTSWIPNHPGGSLIHVKAGQDSTQLFDSYHPLYVRKMLAKYCIGELVPSAGDDKFKKATLEYADAENEDFYLVVKQRVESYFKSNKINPQIHPHMILKSLFILGGYFASYYLAFFWSSSVLVSLFFALWMGFFAAEVGVSIQHDGNHGSYTKWRGFGYIMGASLDLVGASSFMWRQQHVVGHHSFTNVDNYDPDIRVKDPDVRRVATTQPRQWYHAYQHIYLAVLYGTLALKSIFLDDFLAYFTGSIGPVKVAKMTPLEFNIFFQGKLLYAFYMFVLPSVYGVHSGGTFLALYVASQLITGWMLAFLFQVAHVVDDVAFPTPEGGKVKGGWAAMQVATTTDFSPRSWFWGHVSGGLNNQIEHHLFPGVCHVHYPAIQPIVEKTCKEFDVPYVAYPTFWTALRAHFAHLKKVGLTEFRLDG
Protein: Nuclear mRNA export protein SAC3 (Leucine permease transcriptional regulator) (P46674)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:12411502, ECO:0000269|PubMed:14562095}. Note=Localizes to the nuclear pores.
Interaction partners:
- SAGA complex subunit SUS1
- 26S proteasome complex subunit SEM1
- Cell division control protein 31
- Nuclear mRNA export protein THP1
- mRNA export factor MEX67
- Nucleoporin NUP1
- Nucleoporin NUP116/NSP116
- ATP-dependent RNA helicase DBP5
- Nucleoporin NUP159
- mRNA export factor GLE1
Sequence:
MNTSFGSVVPSTNFNFFKGHGNNDNTSANSTVNNSNFFLNSNETKPSKNVFMVHSTSQKKSQQPLQNLSHSPSYTENKPDKKKKYMINDAKTIQLVGPLISSPDNLGFQKRSHKARELPRFLINQEPQLEKRAFVQDPWDKANQEKMISLEESIDDLNELYETLKKMRNTERSIMEEKGLVDKADSAKDLYDAIVFQGTCLDMCPTFERSRRNVEYTVYSYEKNQPNDKKASRTKALKVFARPAAAAAPPLPSDVRPPHILVKTLDYIVDNLLTTLPESEGFLWDRMRSIRQDFTYQNYSGPEAVDCNERIVRIHLLILHIMVKSNVEFSLQQELEQLHKSLITLSEIYDDVRSSGGTCPNEAEFRAYALLSKIRDPQYDENIQRLPKHIFQDKLVQMALCFRRVISNSAYTERGFVKTENCLNFYARFFQLMQSPSLPLLMGFFLQMHLTDIRFYALRALSHTLNKKHKPIPFIYLENMLLFNNRQEIIEFCNYYSIEIINGDAADLKTLQHYSHKLSETQPLKKTYLTCLERRLQKTTYKGLINGGEDNLASSVYVKDPKKDRIPSIADQSFLMENFQNNYNEKLNQNSSVKPQINTSPKRVATRPNHFPFSQESKQLPQISQSHTLSTNPLLTPQVHGDLSEQKQQQIKTVTDGGSPFVFDQSAQNSTVEASKAHMISTTSNGAYDEKLSSEQEEMRKKEEQRIEEEKTQLKKKQENADKQVITEQIANDLVKEVVNSSVISIVKREFSEANYRKDFIDTMTRELYDAFLHERLYLIYMDSRAELKRNSTLKKKFFEKWQASYSQAKKNRILEEKKREEIKLVSHQLGVPGFKKSTCLFRTPYKGNVNSSFMLSSSDKNLIFSPVNDEFNKFATHLTKISKLWRPLEMQSIYYDNLTKKFPSNSLTPANLFIYAKDWTSLSNRWILSKFNLQTAQDSKKFSNNIISSRIICIDDEYEPSDFSDLQLLIFNTGVTNPDIFDLEMKLKDDGEELIKLITGISLNTNICFSLLIIYWESAENTLSESTIKHLLKLNRISKNYSSVIERIDLMNLTEESPHKCLEDKLSEISHSYVYKLTERGKYDKTLRQKRSLAGIHSRSTQLQTTKDIDQKMKKMLEKEKNKYQQQIGERNTYAHLESHIDASPRSKKRKLPILLSTSHSSQFKTPLASRLNTSGSSTSPPLPSHLAMKFRKNSRVTSLHTVLPVSTPSHSNNIPAASFSGNNTTDIQSQQLIENQKSTSVYLNNVSERILGNQEICQTPINPVTPVLDGADQGKEDIPDSILELKILIDSVKKKVNND
Protein: Nuclear receptor 2C2 associated protein (U3KQ53)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQLIRVSQLQIQFQGGFSSRRGCLEGSQGTQALHKIVDFYPEDNNSLQISCPCFWGGWSVPLEALDSPKPEWEP
Protein: Transcription factor aptf-1 (AP2 transcription factor aptf-1) (Q09585)
Organism: Caenorhabditis elegans
Function: Transcription factor, which is required in the single sleep-active ring interneuron RIS for sleep-like behavioral quiescence induced by neuropeptide signaling in larvae. Regulates gene expression of sleep-inducing FMRFamide-like neuropeptide flp-11 in RIS.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92754}.
Interaction partners:
- DeHydrogenases, Short chain
- Homeobox protein ceh-17
- FMRFamide-like neuropeptides 11
- Transmembrane protein
Sequence:
MFNRKLMECSDDEFVRGSQCDEEDEEEQQRQSSQRPPFYENMRTFAPSHMHISCHYDIPYPPHLIQPPVCGVSTFTYAREFPVSNSQQFFNVTPPQQQQQQGTGGSGEEDYCIPKSEDRDHSSNYSQVATKQDRPFVFFASDCQSPLEIVGEVYCTVPGRTSLLSSTTKYRVTVAEIQRRISPPECLNASLLGGILRKAKSKDGGKTLRDSLKKLGLTLPAGRRKQANVTAWTALVEEEAIHMAKEFALVCEKEFHSREIGIYLTKTSLAIDPDVVKRRTALEMSRKVVGELAELLSCDRTPLTPYFPRNMLPIDPSVQQHLSHFTLMTHGFGNVAMSAVLESVKLMIDESIKYIDRCCSQNVWR
Protein: Glutathione S transferase O2, isoform B (EC 1.8.5.1, EC 2.5.1.18) (Glutathione S-transferase omega class) (Q9VSL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MALPQKHFKRGSPKPEIPEDGVLRYYSMRFCPYSQRAGLVLAAKKIPHHTVYIDLSEKPEWYIDYSPLGKVPAIQLPNLPGQPALVESLVIAEYLDEQYPGEGSLFPKDPLQKALDRILIERLSPAVSAIYPVLFTKNPPADAIKNFETALDVFEQEITKRGTPYFGGNKIGIADYMIWPWFERFPALKYTLDEPYELDKTRYQNLLKWRDLVAQDEAVKATALDARIHAKFMKTRHENKPDYDVAFQPL
Protein: Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) (P57075)
Organism: Homo sapiens (Human)
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Tyrosine-protein kinase ZAP-70
- E3 ubiquitin-protein ligase CBL
- Lymphocyte cytosolic protein 2
- T-cell receptor-associated transmembrane adapter 1
- Epidermal growth factor receptor
- Polyubiquitin-C
Sequence:
MAAGETQLYAKVSNKLKSRSSPSLLEPLLAMGFPVHTALKALAATGRKTAEEALAWLHDHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESKRQCAKNRAHEVFPHVTLCDFFTCEDQKVECLYEALKRAGDRLLGSFPTAVPLALHSSISYLGFFVSGSPADVIREFAMTFATEASLLAGTSVSRFWIFSQVPGHGPNLRLSNLTRASFVSHYILQKYCSVKPCTKQLHLTLAHKFYPHHQRTLEQLARAIPLGHSCQWTAALYSRDMRFVHYQTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENYTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQALQATVARKSVLVVRHGERVDQIFGKAWLQQCSTPDGKYYRPDLNFPCSLPRRSRGIKDFENDPPLSSCGIFQSRIAGDALLDSGIRISSVFASPALRCVQTAKLILEELKLEKKIKIRVEPGIFEWTKWEAGKTTPTLMSLEELKEANFNIDTDYRPAFPLSALMPAESYQEYMDRCTASMVQIVNTCPQDTGVILIVSHGSTLDSCTRPLLGLPPRECGDFAQLVRKIPSLGMCFCEENKEEGKWELVNPPVKTLTHGANAAFNWRNWISGN
Protein: Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase) (P69739)
Organism: Escherichia coli (strain K12)
Function: This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth.
Subcellular location: Cell inner membrane; Single-pass type I membrane protein; Periplasmic side.
Interaction partners:
- Hydrogenase-1 large chain
- Hydrogenase-1 operon protein HyaF
- Hydrogenase 1 maturation protease
- Hydrogenase-2 large chain
- Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
- Hydrogenase-1 operon protein HyaE
- Hydrogenase-2 small chain
- Hydrogenase-2 operon protein HybA
- Cytochrome bd-II ubiquinol oxidase subunit 1
- Cytochrome bd-II ubiquinol oxidase subunit 2
Sequence:
MNNEETFYQAMRRQGVTRRSFLKYCSLAATSLGLGAGMAPKIAWALENKPRIPVVWIHGLECTCCTESFIRSAHPLAKDVILSLISLDYDDTLMAAAGTQAEEVFEDIITQYNGKYILAVEGNPPLGEQGMFCISSGRPFIEKLKRAAAGASAIIAWGTCASWGCVQAARPNPTQATPIDKVITDKPIIKVPGCPPIPDVMSAIITYMVTFDRLPDVDRMGRPLMFYGQRIHDKCYRRAHFDAGEFVQSWDDDAARKGYCLYKMGCKGPTTYNACSSTRWNDGVSFPIQSGHGCLGCAENGFWDRGSFYSRVVDIPQMGTHSTADTVGLTALGVVAAAVGVHAVASAVDQRRRHNQQPTETEHQPGNEDKQA
Protein: Numb-like protein (O08919)
Organism: Mus musculus (Mouse)
Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9169836}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 2
- Epidermal growth factor receptor substrate 15
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 4
- Protein numb homolog
- E3 ubiquitin-protein ligase LNX
- Cadherin-1
- E3 ubiquitin-protein ligase Itchy
Sequence:
MSRSAAASGGPRRPDQHLSPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGINALCTQISSSFASAGAPASGPPPATTGTSAWGEPSVPAAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSAPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL
Protein: Small ribosomal subunit protein bS16 (30S ribosomal protein S16) (P0A7T3)
Organism: Escherichia coli (strain K12)
Function: In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity.
Interaction partners:
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein bS18
- Small ribosomal subunit protein bS20
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein bS21
- GTP pyrophosphokinase
- Large ribosomal subunit protein uL14
- DNA-directed RNA polymerase subunit alpha
- Large ribosomal subunit protein uL24
Sequence:
MVTIRLARHGAKKRPFYQVVVADSRNARNGRFIERVGFFNPIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVNKAA
Protein: Chaperone NapD (NapA signal peptide-binding chaperone NapD) (P0A9I5)
Organism: Escherichia coli (strain K12)
Function: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export. May have a role in the insertion of the NapA molybdenum cofactor.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02200, ECO:0000269|PubMed:17901208}.
Interaction partners:
- Periplasmic nitrate reductase
- Ferredoxin-type protein NapF
- Periplasmic nitrate reductase, electron transfer subunit
- Ferredoxin-type protein NapG
- Ferredoxin-type protein NapH
- Cytochrome c-type protein NapC
- Chaperone protein TorD
- Cytochrome c biogenesis ATP-binding export protein CcmA
- Heme exporter protein B
Sequence:
MHTNWQVCSLVVQAKSERISDISTQLNAFPGCEVAVSDAPSGQLIVVVEAEDSETLIQTIESVRNVEGVLAVSLVYHQQEEQGEETP