wanglab/gogpt-training-data huggingface dataset:
Protein: Protein RIF2 (RAP1-interacting factor 2) (Q06208)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.
Subcellular location: Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}.
Interaction partners:
- DNA-binding protein RAP1
- Telomere length regulator protein RIF1
- Cell division control protein 13
- Serine/threonine-protein kinase TEL1
- Regulatory protein SIR4
- Telomere length regulation protein TEN1
- ATP-dependent DNA helicase II subunit 1
- Protein STN1
- Regulatory protein SIR3
- Telomere elongation protein EST1
Sequence:
MEHVDSDFAPIRRSKKVVDSDKIVKAISDDLEQKNFTVLRKLNLVPIKKSVSSPKVCKPSPVKERVDHVFYQKFKSMALQELGTNYLSISYVPSLSKFLSKNLRSMKNCIVFFDKVEHIHQYAGIDRAVSETLSLVDINVVIIEMNDYLMKEGIQSSKSKECIESMGQASYSGQLDFEASEKPSNHTSDLMMMVMRKINNDESIDHIVYFKFEQLDKLSTSTIIEPSKLTEFINVLSVLEKSNNIAFKVLIYSNNVSISSLLSTSLKKKLNTKYTVFEMPILTCAQEQEYLKKMIKFTFDSGSKLLQSYNSLVTCQLNNKESNLAIFFEFLKVFPHPFTYLFNAYTEIIVQSRTFDELLDKIRNRLTIKNYPHSAYNFKKNQRLPLKLTRKVHDR
Protein: T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) (P56280)
Organism: Mus musculus (Mouse)
Function: Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10716693}. Nucleus {ECO:0000269|PubMed:10716693}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Microsomal fraction. {ECO:0000250}.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- Protein TCL1B1
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
- Protein TCL1B2
- Protein TCL1B4
- Protein p13 MTCP-1
- DNA
- B-lymphocyte antigen CD19
- PR domain zinc finger protein 14
Sequence:
MATQRAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQVILRQEDVTLGEAMSPSQLVPYELPLMWQLYPKDRYRSCDSMYWQILYHIKFRDVEDMLLELIDSESNDE
Protein: 60S ribosomal protein L11, putative (Q38EI9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S5, putative
- Ribosomal protein L37
- 60S ribosomal subunit protein L31, putative
- 40S ribosomal protein S4
- 60S ribosomal protein L35A, putative
- 40S ribosomal protein S27, putative
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein uS4
- 40S ribosomal protein S15, putative
- 60S ribosomal protein L6, putative
Sequence:
MAEAKVSAEKKAANPMREIVVKKLCINICVGESGDRLTRASKVLEQLCEQTPVLSRARLTVRTFGIRRNEKIAVHCTVRGKKAEELLEKGLKVKEFELKSYNFSDTGSFGFGISEHIDLGIKYDPSTGIYGMDFYVVLGRRGERVAHRKRRVSRVGFNHRVRKEEAMKWFEKVHDGIIFQAKKKKKSMVRRRRR
Protein: cAMP-dependent protein kinase type II-beta regulatory subunit (P31322)
Organism: Bos taurus (Bovine)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. {ECO:0000250}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Protein kinase cAMP-dependent type I regulatory subunit beta
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- Hormone-sensitive lipase
- Protein kinase cAMP-dependent X-linked catalytic subunit
- Serine/threonine-protein kinase PLK1
- A-kinase anchor protein 10, mitochondrial
- tRNA-dihydrouridine synthase
Sequence:
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQEENERKGTARFGHEGRTWGDAGAAGGGGTPSKGVNFAEEPRHSDSENGEEEEEEAADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
Protein: Ferric uptake regulation protein (Ferric uptake regulator) (A5F6G4)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Function: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MSDNNQALKDAGLKVTLPRLKILEVLQQPECQHISAEELYKKLIDLSEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFELSTQHHHDHLVCLDCGEVIEFSDDVIEQRQKEIAAKYNVQLTNHSLYLYGKCGSDGSCKDNPNAHKPKK
Protein: G patch domain-containing protein 3 (Zgc:158863) (A1L2F7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAASEEVTYFVVNNIPGRFRSADLRNYFSQFIESGGFACFHYRHRPELRVTSGACEAGECEARPAAPADGKQWSSCCCVVSVRAQDSDRFIRMYSGNQWIDSSGNWLRNTCLIRRVRVSEQSDCDLFPYKTKAELRRHVAQSEQFTESDLRDLPELNPPALMPSGNVGTPVSVFLQLIQSCRLPPRLIRKLGLTFPKTGSNRRYGNVPYQYHNTRVVTPAEESVFTAGGVEIKGHAQRDTPTTSHRKQGKPTTLYRTQETPTASQAKQDTPTISLTIQDTPTTTQTNQDTPSTSCIIQDTPTASQRQQDTPTASQKLDMSTTSCKIQDTPTASQRKQDTPTTSCIIQDTPTTSQTVQDTPTTSQKQDMSITSCKIQDTPTASQRKDTPPTSCIIQETPTTSQTKRLNTPTASRKIQDTPTYTQTLYEDTPSPPVNQPSQEEESEEELSGPDDDDDRCEEWERHEALHEDITAQERSKERLFEEEIELKWEKGGSGLVFYTDAQFWQEEEEGDFDEQTADDWDVDMSVYYDKDGGDMDSRAYVRMRSEQRLRDGLTNTHIGSFERFTKGVGRRLMEKQGWRDGEGLGNSQMGMAEALEDEGQHPHCKRGFGYHGEKLNSFLPAKKPRKDFHISTVYDEPRDIDQGDDLLRRQPNTSMKYRQRRMNNNPNR
Protein: Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1) (Q969V5)
Organism: Homo sapiens (Human)
Function: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response. Can mediate RIGI sumoylation and disrupt its polyubiquitination.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:18207745, ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963, ECO:0000269|PubMed:21597459}; Multi-pass membrane protein {ECO:0000255}. Peroxisome {ECO:0000269|PubMed:18207745}. Note=Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. {ECO:0000269|PubMed:18207745}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 D2
- Nuclear receptor subfamily 6 group A member 1
- Transmembrane protein 115
- Ubiquitin carboxyl-terminal hydrolase 30
- Cellular tumor antigen p53
- Vacuolar protein sorting-associated protein 26A
- Mitochondrial antiviral-signaling protein
- E3 ubiquitin-protein ligase MARCHF5
- Ubiquitin-conjugating enzyme E2 D1
- Ubiquitin-conjugating enzyme E2 E3
Sequence:
MESGGRPSLCQFILLGTTSVVTAALYSVYRQKARVSQELKGAKKVHLGEDLKSILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQRTNTVPFDLVPHEDGVDVAVRVLKPLDSVDLGLETVYEKFHPSIQSFTDVIGHYISGERPKGIQETEEMLKVGATLTGVGELVLDNNSVRLQPPKQGMQYYLSSQDFDSLLQRQESSVRLWKVLALVFGFATCATLFFILRKQYLQRQERLRLKQMQEEFQEHEAQLLSRAKPEDRESLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPKKCPICRQAITRVIPLYNS
Protein: Drosophila melanogaster dynein-related heavy chain polypeptide protein (V9GZM8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
CYRTLVGAYQLHLNGAPEGPAGTGKTETTKDLAKALAVQCKVFNCSDGLDYKAMGKFFKGLASCGAWACFDEFNRIELEVLSVVAQQILLIIQAVRSNATKFMFEGTELTLNPACY
Protein: Cell division cycle 14A (A0A0U1RQX7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKKFNSAKEAF
Protein: Dahlein-5.6 (P84272)
Organism: Ranoidea dahlii (Dahl's aquatic frog) (Litoria dahlii)
Function: Has no antimicrobial activity. Strongly inhibits the formation of NO by neuronal nitric oxide synthase at micromolar concentrations.
Subcellular location: Secreted {ECO:0000269|PubMed:11555873}.
Interaction partners:
Sequence:
GLLASLGKVFGGYLAEKLKPK
Protein: T cell receptor alpha chain MC.7.G5 (MC.7.G5 TRA) (TR alpha chain TRAV38-2DV8*01J31*01C*01) (P0DTU3)
Organism: Homo sapiens (Human)
Function: The alpha chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells, even stressed or infected by bacteria. Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:31959982}.
Interaction partners:
Sequence:
MACPGFLWALVISTCLEFSMAQTVTQSQPEMSVQEAETVTLSCTYDTSESDYYLFWYKQPPSRQMILVIRQEAYKQQNATENRFSVNFQKAAKSFSLKISDSQLGDAAMYFCAYRSAVNARLMFGDGTQLVVKPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
Protein: Phytosulfokines 3 (AtPSK3) [Cleaved into: Phytosulfokine-alpha (PSK-alpha) (Phytosulfokine-a); Phytosulfokine-beta (PSK-beta) (Phytosulfokine-b)] (Q9M2Y0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation.
Subcellular location: Secreted.
Interaction partners:
- Phytosulfokine receptor 1
- Phytosulfokines 1
- Subtilisin-like protease SBT1.1
- Thioredoxin-like 3-2, chloroplastic
- Putative phytosulfokines 6
- Phytosulfokine receptor 2
- F-box/kelch-repeat protein At5g49000
- Subtilisin-like protease SBT3.8
- Small polypeptide DEVIL 10
- Secreted transmembrane peptide 5
Sequence:
MGKFTTIFIMALLLCSTLTYAARLTPTTTTALSRENSVKEIEGDKVEEESCNGIGEEECLIRRSLVLHTDYIYTQNHKP
Protein: Migration and invasion enhancer 1 (J3KTI2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDVSIYSVGRTSWSPYPNSASSCHSTPLAH
Protein: Stage II sporulation protein SA (Killer protein SpoIISA) (Toxin SpoIISA) (O34853)
Organism: Bacillus subtilis (strain 168)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20863891}; Multi-pass membrane protein {ECO:0000269|PubMed:20863891}.
Interaction partners:
- Stage II sporulation protein SB
- Antitoxin EndoAI
- Endoribonuclease EndoA
Sequence:
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASLCHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVLPIEEEGEG
Protein: Myb domain protein 9 (F4KE69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase 5
- Cytochrome P450 86B1
- Omega-hydroxypalmitate O-feruloyl transferase
- Cytochrome P450 86A1
- CASP-like protein 1B2
- Telomere repeat-binding factor 1
Sequence:
MGRSPCCDENGLKKGPWTQEEDDKLIDHIQKHGHGSWRALPKQAGLNRCGKSCRLRWTNYLRPDIKRGNFTEEEEQTIINLHSLLGNKWSSIAGNLPGRTDNEIKNYWNTHLRKKLLQMGIDPVTHRPRTDHLNVLAALPQLIAAANFNSLLNLNQNVQLDATTLAKAQLLHTMIQVLSTNNNTTNPSFSSSTMQNSNTNLFGQASYLENQNLFGQSQNFSHILEDENLMVKTQIIDNPLDSFSSPIQPGFQDDHNSLPLLVPASPEESKETQRMIKNKDIVDYHHHDASNPSSSNSTFTQDHHHPWCDTIDDGASDSFWKEIIEQTCSEPWPFPE
Protein: Terpene synthase 9 (EC 4.2.3.-) (EC 4.2.3.15) (EC 4.2.3.47) (Q54YE2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene beta-barbatene as a major product as well as (E)-beta-farnesene as a minor product. Is also able to convert geranyl diphosphate (GPP) into a mixture of monoterpenes including (Z)-beta-ocimene, linalool, beta-myrcene, limonene and alpha-terpineol.
Interaction partners:
Sequence:
MYSLHDFKFPEDWIEPPANDKCIYTCYKEVVDFKLFEENKKTLEYYYGTISSTIYLYPLCNYEQLLVASRYLTVCFVVDDFLESKLTNPDDSRELIKKLEHIFMDGNFYDSNNISNIEKYVLYFRETTKQFVGEKIEFFNQFLKFIIDWINSINPFNRADNLNNYDSYNFFKRTNSGTYVSLSVAMLLYPNSKIDPKIWINPRFDRFATNGGYQMATMNDCASYAKEIRNNNHLTNPLHFLQNQVGSFDNVYKVILKFNDEIMNQICEDERILLLECPIEQRDDLKLLTRSMKLILGGNYLWSLQCSRYVDINSPFIEQRSNDPNVIAYEKIVDKILLK
Protein: Pre-mRNA-splicing factor SNT309 (PRP19-associated complex protein 25) (Synergistic to PRP19 mutation protein 309) (Q06091)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing by stabilizing the NTC (or PRP19-associated complex). As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Small nuclear ribonucleoprotein G
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-splicing factor CWC21
- Pre-mRNA-splicing factor NTC20
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-splicing factor ISY1
- Pre-mRNA-splicing factor SLT11
- Pre-mRNA-splicing factor SPP2
- Pre-mRNA-splicing factor CLF1
Sequence:
MDGLSFVDKGKIPDGYKNEIDQLVKKEFANIKREPVHPEIRGILAKRKGADNSVSTLTNALYTEYLKQRNNKKRRTPDFNDDDDTLFLEEYRRKYPRIDTSRYIPNESSEVSLLGIVDSYLKHQEIVLDTLLPQTVSNQWRINNDYIRQTCTIVEEMNIQQRKQINDLEIYRKRL
Protein: Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (E9PL19)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEQLNLADSGLVGKEARRCRRASPPMGMPSAWWLQNEAGCLFAARQVNGQQGGGSEPAAAAAVVAAGDKWKPPQGTDSIKMENGQSTAAKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLGTLGTPGLVSPALTLAQPLGTLPQAVMAAQAPGVITGVTPARPPIPVTIPSVGVVNPILASPPTLGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQERFDNSDLSA
Protein: Protein ALWAYS EARLY 3 (AtALY3) (Q6A332)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Retinoblastoma-related protein 1
- Histone-binding protein MSI1
- Transcription factor E2FC
- Transcription factor-like protein DPB
- Transcription factor-like protein DPA
- Transcription factor MYB3R-3
- Protein ALWAYS EARLY 1
- Protein ALWAYS EARLY 2
- Transcription factor E2FB
- Hydroxyproline-rich glycoprotein family protein
Sequence:
MAPSRSKKSKYKKKPRAKAVSPHKDEESMSKTKQRKRKLSDMLGPQWSKEELERFYEGYRKFGKEWKKVAGFVHSRSAEMVEALYTMNKAYLSLPEGTASVVGLTAMMTDHYSVLHGGSDSEQENNEGIETPRSAPKRSRVKSSDHPSIGLEGLSDRLQFRSSSGFMPSLKKRRTETMPRAVGKRTPRIPISYTLEKDTRERYLSPVKRGLNQKGDDTDDDMEHEIALALAEASQRGGSTKNSHTPNRKAKMYPPDKKGERMRADIDLAIAKLHATDMEDVRCEPSLGSTEADNADYSGGRNDLTHGEGSSAVEKQQKGRTYYRRRVGIKEEDAKEACSGTDEAPSLGAPDEKFEQEREGKALKFTYKVSRRKSKKSLFTADEDTACDALHTLADLSLMMPETATDTESSVQAEEKKAGEAYVSDFKGTDPASMSKSSSLRNSKQRRYGSNDLCNPELERKSPSSSLIQKRRQKALPAKVRENVLKDELAASSQVIEPCNSKGIGEEYKPVGRGKRSASIRNSHEKKSAKSHDHTSSSNNIVEEDESAPSNAVIKKQVNLPTKVRSRRKIVTEKPLTIDDGKISETIEKFSHCISSFRARRWCIFEWFYSAIDYPWFARQEFVEYLDHVGLGHVPRLTRVEWGVIRSSLGKPRRFSEQFLKEEKEKLYLYRDSVRKHYDELNTGMREGLPMDLARPLNVSQRVICLHPKSREIHDGNVLTVDHCRYRIQFDNPELGVEFVKDTECMPLNPLENMPASLARHYAFSNYHIQNPIEEKMHERAKESMLEGYPKLSCETGHLLSSPNYNISNSLKQEKVDISSSNPQAQDGVDEALALQLFNSQPSSIGQIQAREADVQALSELTRALDKKELVLRELKCMNDEVVESQKDGHNNALKDSESFKKQYAAVLFQLSEINEQVSLALLGLRQRNTYQENVPYSSIRRMSKSGEPDGQLTYEDNNASDTNGFHVSEIVESSRIKARKMVYRAVQALELLRKDENNNVNMEEAIDFVNNQLSIDQTEGSSVQQTQGGQDQRLPSTPNPPSSTPANDSHLNQPDQNDLQVPSDLVSRCIATLLMIQKCTERQFPPSEVAQVLDSAVASLQPCCSQNLPIYTEIQKCMGIIRNQILALVPS
Protein: JadH (Q5U913)
Organism: Streptomyces venezuelae
Interaction partners:
Sequence:
MTTTPEAGFDADVIVVGAGPTGLMLAGERRLGGARVLVAERLERPTGQSRGLGFTARAMEVFDQRGLLPRFGQGETLETSPMGHFGGVQFDYTVLEGAHFGARGIPQYTTESVLEEWATELGADIRRGWEFTGLDQDDDAVEITVRTPEGERRLRAAYVVGCDGGHSPVRKAAGFDFPGTPATREMYLADVVGCGLKPRFLGERLPEGMVMAAPLAEGVDRIIVCPHGTPPRDRRDAQAVSFAEVAAAWQRITGEDISGGSAEWVSSFTDTTRQATEYRRGRVLLVGDAAHIHLPAGGQGLSTGVQDAANLGWKLAAVVRGTAPDGLLDTYHGERHPVGQRLLMNTRAQGTVFLGGEESDPLRELFTELLAYDDVKRHLAGVVSGLDIRYDLAGGADDPLVGARLAHRALTTAAGETSTTRLVHAGQGVLLDLADDPAVRDAAAAWKDRVVTVTGTPLPVEGTDVLAGVTAVLVRPDGHVAWTARAAGADASDAGTEAGAAASLAGTDAEGLGASLRRWFGEPASDASVTPGASADGGAAR
Protein: Eukaryotic translation elongation factor 1 delta (E9PRL0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRSGKASCTLETVWEDKHKYEEAERRFYEHEATQAAASAQQLPAEGPAMNGPGQDDPEDADEAEAPDGGSRRDPRKSQDSRKPLQKKRKRSPKSGLGPADLALLGLSAERVWLDKSLFDQAESSYRQKLADVAAQAAWPPALAPWGLCTHGNQVACHHVTWGIWVNKSSFDQAERAFVEWSQALLLAPDGSRRQGTPNTGQQVAVPDLAHQPSPPVNGQPPLGSLQALVREVWLEKPRYDAAERGFYEALFDGHPPG
Protein: Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (Q5F2E8)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade (By similarity). During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 3
- Dual specificity mitogen-activated protein kinase kinase 6
- Serine/threonine-protein kinase TAO2
- Serine/threonine-protein kinase TAO3
- Cell division cycle protein 20 homolog
- Serine/threonine-protein kinase PLK1
- Nuclear migration protein nudC
Sequence:
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNPTGGPGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Protein: Probable eukaryotic initiation factor 4A (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A) (Q4Q5P5)
Organism: Leishmania major
Interaction partners:
- PRP1 splicing factor N-terminal domain-containing protein
- Small nuclear ribonucleoprotein component-like protein
Sequence:
MYKNQAQPQLQPQPQPQSQPQPQEPSAIAGAMGGYGSYQQQNRQYGGGNRGFNDAQGTYGGGFNRNGGGGGFRGGFGGFGGGARGPVRELVGNNHYHREEKSEEEIFKEHTPGINFDQYEAIKVSITPNDVEPAESFATMALAPALAENVNRCRYQKPTPVQKYGIPCVLNGSDLMACAQTGSGKTAAYLIPAINFMLVNNLNRAKPTNSQAAPSALVLSPTRELSIQIYEEGRKFTYRTGFRCVVVYGGADPRHQIHELTRGCGLLVATPGRLSDMFTRGYTRYSDVRFLVLDEADRMLDMGFEPQIRAIVQGPDSDMPPPGERQTLLYSATFPKEIQQMAREFLYHHHFLQVGRVGSTTENITQDVRWVEDMDKRGCLLEVLKEHQGERVLVFVEKKRDADYLERYLRQSRIPCSSIHGDRVQREREEALDIFKSGVCRVLVATDVASRGLDIPNVAVVVQYDLPSNIDDYVHRIGRTGRAGKRGTAISFFNDKNRNIVDDLIPLLRETNQTVLPEVQALAKKPNVQNQPRGRGRGGFRSGGFGGGFGGGYGGGYGGRGGYRGGGGFGGGYGGGYGGGYGGNNGGYRPRGGYGGGYGGGYGGDRNMRSDVFGQ