wanglab/gogpt-training-data huggingface dataset:
Protein: High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) (O54879)
Organism: Mus musculus (Mouse)
Function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P40618, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19890330}.
Interaction partners:
Sequence:
MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSSKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLSDNEKQPYVTKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEEEEEEEEEEEEEEEEDE
Protein: Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) (P09812)
Organism: Rattus norvegicus (Rat)
Function: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Interaction partners:
- Glycogen debranching enzyme
- 1,4-alpha-glucan branching enzyme
- Phosphoglucomutase-1
- UTP--glucose-1-phosphate uridylyltransferase
- Pancreatic alpha-amylase
- Alpha-amylase.
- Phosphoglucomutase 2-like 1
- Receptor-interacting serine/threonine-protein kinase 3
- Glycogen phosphorylase, liver form
- Glycogen [starch] synthase, muscle
Sequence:
MSRPLSDQDKRKQISVRGLAGVENVSDLKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVDRWIRTQQHYYAKDPKRIYYLSLELYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPPYFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDKFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELIRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEEYISDLDQLRKLLSYLDDQAFIRDVAKVKQENKLKFSAYLETEYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRFRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEDNFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMVMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGLEPSRQRLPAPDEKI
Protein: Sorting nexin 1 (H0YK58)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
GGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKCWDYRREPPHPALSCFLKDLKASTQ
Protein: Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)] (Q94527)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor that plays a key role in the humoral immune response as part of the peptidoglycan recognition protein (IMD) signaling pathway. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. Also part of some antiviral immunity: activated downstream of Sting signaling, which detects double-stranded RNA (dsRNA) from viruses, and promotes expression of antiviral effector genes. May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system. Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk.
Subcellular location: [Nuclear factor NF-kappa-B p68 subunit]: Nucleus.; SUBCELLULAR LOCATION: [Nuclear factor NF-kappa-B p110 subunit]: Cytoplasm.; SUBCELLULAR LOCATION: [Nuclear factor NF-kappa-B p49 subunit]: Cytoplasm.
Interaction partners:
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Diptericin B
- Protein immune deficiency
- Cecropin-A1
- Diptericin A
- Cecropin-B
- Cecropin-C
- Dorsal-related immunity factor Dif
- Peptidoglycan-recognition protein LB
- Poor Imd response upon knock-in, isoform A
Sequence:
MNMNQYYDLDNGKNVMFMNDASSTSGYSSSTSPNSTNRSFSPAHSPKTMELQTDFANLNLPGGNSPHQPPMANSPYQNQLLNNGGICQLGATNLINSTGVSFGVANVTSFGNMYMDHQYFVPAPATVPPSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEKFRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVIRCSLFQTNLDSPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKPRSVIVSRKRRRTGSSANSSSSGTESSNNSLDLPKTLGLAQPPNGLPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQHDGHNRAEVPSHRNRTIKCLDDLFEIYKQDRISPIKISHHKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTVQLDLSLTNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLEQSVELLVLILDAQNENLTDILQAQNAAGHTPLELAERKANDRVVQLLKNVYPEKGELAMTWIPCKVKEEIDSSSDESSDAGQLEIKSEEMDIETKDEDSVELDLSSGPRRQKDESSRDTEMDNNKLQLLLKNKFIYDRLCSLLNQPLGHGSDPQDRKWMQLARQTHLKQFAFIWLGAEDLLDHVKRKGASVEFSTFARALQAVDPQAYALLVNPT
Protein: Non-reducing polyketide synthase PKS1 (EC 2.3.1.-) (Conidial pigment biosynthesis cluster 29 protein PKS1) (F9XMW3)
Organism: Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Function: Non-reducing polyketide synthase; part of the gene cluster 29 that mediates the biosynthesis of mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase PKS1 though condensation of acetyl-CoA with malonyl-CoA (By similarity).
Interaction partners:
Sequence:
MSNILLFGDQTAEQYPLLHRIVLRKDNVLLLSFVERCALALREETRTLSRSQREVMPDFLTLSNLIEAYYQKGEKVLMLESAFLTIAQLGHYIGYFSENPSELPAVSDTRVLGLCTGLLAASAVVSAKTVEELAIVGVDFVRIAFRSGAVVDNVRSMLGQSSQDKSTWSTIISGPSEVDVKDALTSFHEASGIPRSNQAYVSAVSTMALTVSGPPITVERFFQESSLIINHRVSIPIYGPYHAGHLFGEAECERILSGEVGQELRKHMPASLVHSAATGKPIVSENAYELAKLALGEIHQYPVRWDYLLEETVAQIGHYPCGAKIFALGASNIATSLSSALKAGGQADVMIVDEASFVETKKYTGRTQTDKIAIVGMAGRFPNSANHEALWDLLMKGLDVHRKVPADRFDADAHCDPSGKGKNKSHTPFGCFIDEPGLFDPRFFNMSPREAAQTDPMGRLALVTAYEALEMSGYVPNRSTSTKLNRIGTFYGQTSDDWREINAAENVDTYYITGGVRAFAPGRINYYFKFSGPSYSIDTACSSSLAAIQLACTSLWAGDCDTACAGGLNVLTNPDIFSGLSKGQFLSKTGGCKTYDNDADGYCRGDACGTVILKRYQDAVADKDNILGCILGAATNHSAEAVSITHPHAGAQEFLYKQVLANAGIDAHEISYVEMHGTGTQAGDGIEMTSVTNVFAPRRRQRKPEQTVHLGAIKANVGHAEAASGINSLVKVLMMMKNNKIPANVGVKGELNKTFPADLKDRNVHISLKQVDWPRKTEAPRKVFLNNFSAAGGNTALLIEDGPVHKMPNGVDPRSTLPITVTARSIGSLKRNLMNLQKYVAENGSTTLPSFSYTLTARRIQHNYRVAFPLADISKVADALEAQAKDSYSPVPMVTTKTAFCFTGQGSQYTGLGQKLYQDLKSFRDDIDQLDQMARIQGLPSFLELLDGTDVQTLSPVKVQLGMACIQVALSRMWASWGVTPTAVIGHSLGEYAALHVAGVISASDMVLLVGRRAELLVRECTPHTHGMLAVKGGVEAIRNALGINMTEIACINGPEETVLCGSSDVVAAANDTLGKNGFKATKLNVPFAFHSAQVDPILDEFRKVASSVTFNKPSVPILSPLVGIVIRDGGIITADYLARHARETVNFSSALLSGQKEAVFDEKTAWLEVGAHPVCSGMVKASIGTTITAPSLRRGEDAWKTISTSICHLFTAGVNFNFDEFHREFNDAQELLTLPTYSFDNKKYWLDYHNNWTLTKGEVQKTKEVIVEKEIVAPVIEVPAKRLSTSCQNVISEEFDGNRATVVIRSNLADSKLYPVVCGHMVNNAALCPSSLYADMALTVGDYIYKELQPGVETPGMNVCNMEVPKPFIANIPQPAEGQHLEMEATADLDLGTVSLKFRSVHPDGKKIQDHAFCTIRYEDKAVWASEWTRYNYMVKAQIDMLTARTMTGGAHKVQRGMAYKLFKALVNYDDKYRAMAEVVLDGANTEASAAIDFPTKPDDGDFYCPPYHIDGACHISGFIVNASDLLDSEQNVYVSHGWGAMKFSRPLVAGMKLRNYVRMVPQPNNISKGDVYIMEGDEIVAVCEGIKFQQIPRKVLNVFLPPNKGSAVQAKPSPIAQRPAPVRASVAAPVKRMLAPAPVRKSAGPAKAAAAPSMPKPSKVAAKKPAGSMVDKVLTILSKETEVDVAELVDDAHFENLGVDSLLSLTISAIFREDLSMEISPSLFTDYPTVGEMKKYFSQFNNVESTTESEDDSDTDSLATTDVATPFDEMSTPASSAPSVPQSDAGKPSPDSPTGDSLSDDVGDVSIARHIIAQEMGVDISEVTDDAELAEMGMDSLMSLTILGELREKTGIDLPGTFLMTNPTLVDIENALGMRPKPKAVGPKLSKPSTKTDMNEVSSRLTAINKTDISQYPSATSVLLQGNPKTATKKVFFLPDGSGSATSYVSIPNIGPHVAAFGLNCPFMKDPEQWQCGIEVSSLIYLAEIRRRQPKGPYIIGGWSAGGVIAYAVAQALLAAGEKVEKLLLLDSPCPVNLAPLPTRLHVFFNEIGLLGTGDPAKTPKWLLPHFSAAIRSLSAYDPKPTIAELPTYAVWCKDGVAGNPGDPRPPPAEEEDPAPMKWLLNHRTDFSDNGWAQLCGQNMKFGVMGGHHFSMMKDPHASELGQLIKEGIEWKA
Protein: Calpain-D (EC 3.4.22.-) (Calcium-activated neutral proteinase D) (CANP D) (Small optic lobes protein) (P27398)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in eye development.
Interaction partners:
- SD23764p
- CAP, isoform X
- Structural maintenance of chromosomes protein
- U3 small nucleolar RNA-associated protein 15 homolog
- LD30155p
- Histone chaperone asf1
- 26S proteasome non-ATPase regulatory subunit 1
- tRNA
- HDC05827
- NHP2-like protein 1 homolog
Sequence:
MGTISSVLQWSCTKCNTINPTESLKCFNCGTVRKVFPQQQQQQHRSSSITASWTADDALEQEQAEKGQERDKEKGRAAVARSEYKHVYKSLLRGCLKRPQRNSQNLPANCVDCEDTRKYIKSSIELYRHFSNPALNRRWVCHACGTDNSSVTWHCLICDTVSYLAPIYKDAIAADRGQDLAGSLGNRGELLAADHSHPHHHHHYLHQELEEQHQHQLHSQHLHKRHLKGRSASGSGSGPGSGSGLRRTQSLSTAIDKSASGRSCHICYANNQSKDIFNLPQIKPAPQLTGIPPVAACSNSRFAIANDTFCRRKQNNNNKNQNHKVVRESGAKRKYNFTITTLSRSAAKDAGHGQMKPLRQVVNLNLNLQQEPQQKSPANPQQLQRKTQREPAAVSMNPTQFTIPRNGVFIAVNEWSEPMASSSSVSSSSNHHHHHHSNSNSNSSGNSNIINNNSSSSSGSNKLYENECVALAQQQLRAAAAQAAQAAATAVAIASSPSAKAMAEPAPTATMPIYAQVNKQHKLKKKQQIASESQTNNNTGSGEIADAVSESLTAGLGTSTDGSGEASESESQVEEHSIYAKVWKGPRKATESKIMHDPGSSSRLSGAASAAAGTASAGAIAAAVGAAAASRHDNKTQLGNGSRSKMWICIKCSYAYNRLWLQTCEMCEAKAEQQQQQLQLQQQQQQQQQHHHHHLQQQQAEAPRDEPWTCKKCTLVNYSTAMACVVCGGSKLKSISSIEDMTLRKGEFWTCSHCTLKNSLHSPVCSACKSHRQPQLSMAMEAVRERPDGQSYEEQDAAAVGGGGGSAHQSGANEVKAPTALNLPLTSVALPMPMLQLPTSTAAGLRGSRSPSPRMQLLPSLQQQRNSSSSGAIPKRHSTGGSIVPRNISIAGLANYNLQQGQGVGSASVVSASGAGSGAGAVGASTSTKKWQCPACTYDNCAASVVCDICSSPRGLASAVLGEALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQGAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQGHRLLKLRNPWGHYSWRGDWSDDSSLWTDDLRDALMPHGASEGVFWISFEDVLNYFDCIDICKVRSGWNEVRLQGTLQPLCSISCVLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGCHKMLERDIYLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGLHDWGPPGATHCPPIENVHGLHAPRLIT
Protein: Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) (O08619)
Organism: Rattus norvegicus (Rat)
Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00488}. Secreted {ECO:0000250|UniProtKB:P00488}. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. {ECO:0000250|UniProtKB:P00488}.
Interaction partners:
- Coagulation factor XIII B chain
- Prothrombin
- Apelin receptor
- Fibrinogen alpha chain
- Apelin
Sequence:
MSDTPATTFGGRGAIPPNNSNAAGVDLPTEDLQGLVPRGVSLKDYLNVTAVHLFKERWDSNKIVHHTDKFDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVIGRYPQENKGTYIPVPVVTELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVWTPYGILRTQRDPETDTYILFNPWCEEDAVYLDDEKEREEYVLNDIGGIFHGDFNDIKSRSWSYGQFEDGILDACLFVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYAYGIPPSAWTGSVDILLEYRSSETPVRYGQCWVLAGVFNTFLRCLGIPARVITNYSSAHDNDANLQMDIFLEEDGSVSFKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAVKHGHVCFQFDAPFVLGEVNSDLVYITAKKDGTHVVENVDATHIGKLIVTKEIGGDGMQDITDTYKFQEGQEEERLALETALMYGAKKTLNTEGMVKSSSDVDMNFDVENAVLGKDFRVTITFQNNSSNLYTILAYLSGNITFYTGVSKKEFKTESFEVTLDPLSLEKKEVLIRAGEYMSYLLEQGLLHFFVTARINETRVVLAKQKAIVLTIPKVTIKVRGTAMVGSDMVVTVEFTNPLKETLKNVWLHLEGPGVMRPKRKMFREIRPNATVQWEEVCQPWVSGHRKLNASMTSDSLRHVYGELDLQIRRRPTV
Protein: Crooked legs, isoform G (M9PCY3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQHVSAASSVPSVVTPVVTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEMYKVNIEDISQLFTYHEVFGKIHGDVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
Protein: Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin) (P12645)
Organism: Homo sapiens (Human)
Function: Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways.
Subcellular location: Secreted.
Interaction partners:
- Activin receptor type-2B
- Protein NDRG4
- Ameloblastin
- Activin receptor type-2A
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
Sequence:
MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
Protein: Probable indole-3-pyruvate monooxygenase YUCCA5 (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA5) (Protein SUPPRESSOR OF ER 1) (Q9LKC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin biosynthesis. Belongs to the set of redundant YUCCA genes probably responsible for auxin biosynthesis in roots.
Interaction partners:
- L-tryptophan--pyruvate aminotransferase 1
- Tryptophan aminotransferase-related protein 2
- Tryptophan aminotransferase-related protein 1
- Aromatic aminotransferase ISS1
- Protein indeterminate-domain 14
- Tryptophan aminotransferase-related protein 3
- Indole-3-acetaldehyde oxidase
- Amidase 1
- Nitrilase 2
- Auxin efflux carrier component 3
Sequence:
MENMFRLMGSEDSSDRRRCIWVNGPVIVGAGPSGLATAACLREEGVPFVVLERADCIASLWQKRTYDRIKLHLPKKVCQLPKMPFPEDYPEYPTKRQFIEYLESYANKFEITPQFNECVQSARYDETSGLWRIKTTSSSSSGSEMEYICRWLVVATGENAEKVVPEIDGLTTEFEGEVIHSCEYKSGEKYRGKSVLVVGCGNSGMEVSLDLANHNANASMVVRSSVHVLPREILGKSSFEISMMLMKWFPLWLVDKILLILAWLILGNLTKYGLKRPTMGPMELKIVSGKTPVLDIGAMEKIKSGEVEIVPGIKRFSRSHVELVDGQRLDLDAVVLATGYRSNVPSWLQENDLFSKNGFPKSPFPNAWKGKSGLYAAGFTRKGLAGASADAVNIAQDIGNVWREETKRQKMRTRVGHRRCISVA
Protein: Transmembrane protein 163 (Synaptic vesicle membrane protein of 31 kDa) (A9CMA6)
Organism: Rattus norvegicus (Rat)
Function: May bind zinc and other divalent cations and recruit them to vesicular organelles.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17623043}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21668449}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Note=Glutamatergic synaptic vesicles. {ECO:0000269|PubMed:17623043}.
Interaction partners:
Sequence:
MERAPGSERRSPPGPGVPRPPPRGHAPSTAAPAPNPAPLSSSMQPDEERQPRISESGQFSDGFEDRGLLESSTRLKPHEAQNYRKKALWVSWLSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSVLAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHNAAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE
Protein: Recombination signal-binding protein for immunoglobulin kappa J region b (Su(H)B) (A4FTT4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Mastermind-like transcriptional coactivator 1.
- Notch receptor 1b.
- Notch receptor 3.
- Neurogenic locus notch homolog protein 2 precursor
- Nuclear receptor corepressor 2
- Histone deacetylase 1
- C-terminal-binding protein 1
- C-terminal-binding protein 1
- SNW domain-containing protein 1
Sequence:
MAPVVTGKFGERPQPQRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGCGWKKKREQMERDGCSEQESQPCAFIGIGNSEQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSADIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDEESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVHTPVTPVPVVESLQLNGGGDVAMLELTGQNFSPTLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTTLTFTYTPEPGPRPHCSAAGAILRTGSASLLSISGNSTGGNGETAPYGTNNAVTASSSNAAAAVVL
Protein: Gigantea (I1HCQ1)
Organism: Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Interaction partners:
- PAS domain-containing protein
- Pseudo-response regulator 1
- Protein EARLY FLOWERING 3
- PAS domain-containing protein
- RING-type domain-containing protein
- PAS domain-containing protein
- Uncharacterized protein
- Light-mediated development protein DET1
- Phytochrome B
- Pseudo-response regulator
Sequence:
MSASNGKWIDGLQYSSLFWPPPHDAQQKQVQILAYVEYFGQFTSDSEQFPEDVAQLIQSCYPAKEKRLVDEVLATFVLHHPEHGHAVVHPILSRIIDGTLSYDRHGFPFNSFISLFTQTSEKEYSEQWALACGEILRVLTHYNRPIFKVAERNSTSDQATASYSVQEKANGSPGNEPDRKPLRPLSPWITDILLTAPLGIRSDYFRWCGGVMGKYAAGGELKPPTTAYSRGAGKHPQLMPSTPRWAVANGAGVILSVCDEEVARYETANLTAAAVPALLLPPPTTPLDEHLVAGLPPLEPYARLFHRYYAIATPSATQRLLFGLLEAPPSWAPDALDAAVQLVELLRAAEDYATGMRLPKNWLHLHFLRAIGTAMSMRAGMAADTAAALLFRILSQPTLLFPPLRHAEGLEVQHEPLGGYVSSYKRQLEVPASETTIDATAQGIASLLCAHGPDVEWRICTIWEAAYGLLPLNSSAVDLPEIVVAAPLQPPTLSWSLYLPLLKVFEYLPRGSPSEACLMRIFVATVEAILRRTFPSETSEPSRKPRSQSKNLAVAELRTMIHSLFVESCASMNLASRLLFVVLTVCVSHQALPGGSKRPTGSDNHSSEEATEGSRLTNGRNRVKKKQGPVGTFDSYVLAAVCALSCELQLFPILCKNGTHSNIKDSIKIIMPGKTNGISNELQNSISSAVIHTRRILGILEALFSLKPSSVGTSWSYSSNEIVAAAMVAAHVSELFRRSRPCLNALSSLKRCKWDAEISTRASSLYHLIDLHGKTVSSIVNKAEPLEAHLTLTSVRKDDGQHIEENNVSSSDSDDLGKKNVLASHKKNGFSRPLLNCGEEAIRNGGVASTSGKVIATLQVEASDLANFLTMDRNGGYGGSQTLLRSVMSEKQELCFSVVSLLWQKLIASPEMQMSAESTSAHQGWRKVVDALCDVVSASPAKASTAIVLQAEKDLQPWIARDDEQGQKMWRVNQRIVKLIAELMRNHDSPEALVILASASDLLLRATDGMLVDGEACTLPQLELLEVTARAIHLIVEWGDPGVAVADGLSNLLKCRLSTTIRCLSHPSAHVRALSMSVLRDILNSGPINSTKIIQGEQRNGVQSPTYQCAAASMVNWQADMERCIEWEARSRRATGMTLAFLSAAANELGCPLPC
Protein: ATP-dependent helicase upf1 (EC 3.6.4.12) (EC 3.6.4.13) (Nonsense-mediated mRNA decay protein upf1) (Regulator of nonsense transcripts 1 homolog) (Up-frameshift suppressor 1) (Q09820)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Associates with polysomes. {ECO:0000250|UniProtKB:P30771}.
Interaction partners:
- Nonsense-mediated mRNA decay protein 2
- Nonsense-mediated mRNA decay protein 3
- Eukaryotic peptide chain release factor GTP-binding subunit
- Eukaryotic translation initiation factor 4 gamma
- Uncharacterized serine-rich protein C2F12.03c
- ATP-dependent RNA helicase fal1
- Polyadenylate-binding protein, cytoplasmic and nuclear
- mRNA decapping complex subunit 2
- Nuclear cap-binding protein subunit 1
- Nuclear cap-binding protein subunit 2
Sequence:
MSLGLQPNNDISSLVSSKNMTSENGLEHQFEELLVEKQYSEEHCAYCHIKNPNSILKCLHCNKWFCNVRGKSGASHIISHLVRARHKQVALHSHSSLSDTVLECYNCGTRNVFLLGFIPAKAKTVVVLLCRQPCARASIAKDMNWDLTQWQPIISDRQFLPWLITPPSEEEQKLAIPITSQQMVRLEELWRKDPNANLEDLDKPIEDDSLPSVELRYKDAHAYQAVLSPLIQAEADYDKRLKESQTQKDVVVRWDQAINKRYTAWFLLPKLESGEIRLAIGDEMKLTYEGELRAPWSSTGYVIKIPNNVSDEVGLELKRSDKVPIECTHNFSVDYVWKSTSFDRMQTALRLFATDGSRLSSFLYHKLLGHDIPPSFLKPKLPSDLSVPNLPKLNASQSEAVRAVLSKPLSLIQGPPGTGKTVTSASVVYHLATMQSRKRKSHSPVLVCAPSNVAVDQLAEKIHRTGLRVVRVAAKSREDIESSVSFLSLHEQIKNYKFNPELQRLLKLRSENNELSIQDEKKLRILVAAAEKELLRAAHVICCTCVGAGDRRISKYKFRSVLIDEATQASEPECMIPLVLGAKQVVLVGDHQQLGPVVMNKKVALASLSQSLFERLIILGNSPFRLVVQYRMHPCLSEFPSNTFYEGTLQNGVTTSERIARHVDFPWIQPDSPLMFYANFGQEELSASGTSFLNRTEASTCEKIVTTFLRSNVLPEQIGIVTPYDGQRSYIVQYMQNNGSMQKDLYKAVEVASVDAFQGREKDFIILSCVRSSEHQGIGFVNDPRRLNVALTRAKYGVIVLGNPKVLAKHALWYHFVLHCKEKGYLVEGTLNSLQKFSLTLTPPQKPQKFKRDLNVQRSLSPIQNAGSAMLPSFSNLPNLYSSSYLEEWNVFAQYKRRESNATDFEDFRSQVGDDESKFDEPTRF
Protein: F-box protein SKIP1 (SKP1-interacting partner 1) (Q9FDX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-like protein 3
- Putative cullin-like protein 2
- Putative cullin-like protein 1
- Cullin-1
- Cullin-2
- SKP1-like protein 1A
- At2g44200/F6E13.34
- F-box protein SKIP5
- AT3G18790 protein
- At1g53100
Sequence:
MEEDGSDWGGLAPEILINIISRLTIQELWTGPMFVQKSWLTVCRDPYLWSIFDLEPWFDSYPESTHLWSPEFEQKVDLMLRSVVDWSEGGLTKIRVRHCSDHALSYAADRCPNLQVLAIRSSPNVTDASMTKIAFRCRSLKELDISYCHEISHDTLVMIGRNCPNLRILKRNLMDWSSRHIGSVPTEYLDACPQDGDTEADAIGKHMINLEHLEIQFSRLSVKGLASICEGCPKLEYLDLFGCVHLSSRDITSNVSRLKWLKEVKKPDVYVPRSGDVAQTERYGHWRLYDERFDIQAMRI
Protein: Orf165 protein (Q35961)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MLGKALSPLCFVSFYLSSSLDETSTSMKAPPTTPPYPSHSSFRWSFIYPLIVLGTTIARSREFTGQTMSIEKGGSGGLVSVLRFTSTHFRTNRNLAIRTLHSISLASIHLFCSIIHQLLSYNSLSLAFSFVLRWNRTTEGFQGQCPLLFPLKQAKKDLQSFALTS