wanglab/gogpt-training-data huggingface dataset:
Protein: RNA interference and gene silencing protein (Qde2), putative (AFU_orthologue AFUA_8G05280) (Q5BD61)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Nucleoporin NSP1
- RNA helicase/RNAse III, putative
- Dicer-like protein 2
- Nucleolar RNAse III, putative
- Translin-associated factor TraX, putative
- RNAse III, putative
- Recombination hotspot-binding protein
Sequence:
MSSAGGSPQRGSRGRGNDRGRGRGLFHGDRGRGRGGGRGLFNDLPHRPAPGDPGRGGSRGRAGRGGRGGGGGLDQGPPIYLPPDGAPQPNVKVTQTENSQAAALVKKEKTAGYPERPGYGTQGHPIQLFANYLELKSSGKSLFRYHINIDGGGRKPSSRKAKQIICLLLEDHFSPFRHSIVTDYRSNLISHLEILDHEQPSVKYNVTYRSEKEDEPRDTSETYRITCKFTGRLDPADLLNYLTSSNAASMLQEKAEILQALNIVLGHHPKSTGSIASVGTNKHYAIHDNAAEKFDLGAGLEALRGYFVSVRAATARLLVNIQVKYVACYQDGPLYQVIREFQCANGRNVYALKRFLGRLRVEVTHIKRKNKRGEYIPRIKTITNLATPQDGTQDGNKCKDAPKVKFIGAGPNDVSFFLDDPEQGKGSKKAGPKPSGTYITVAEFFKEYYRIQVDPDMPVVNVGSIAKPSYLPVEVCDVLSGQPAKTKLSSNQTRQMLNFAVRSPAQNAHSIVTKGTQILGLRDPTAATLVDFGIQTNPNLITVPGRVLAPPTVYYKDEKSKDKEIAPMSGSWNMKSIRFSTSSNLQSWACILITAGPKQHFQSPDDLEDCLYRFTKKLREVGVNANPPVFKVRVQVTKENAETVIDAEIRKILHQHRPKLILTILPFNDTALYNCIKRACDVRHGVRNINVLAEQFCKRNEQYFANVGLKFNLKLGGVNQVVRPSQLGIIGEGKTMLIGIDVTHPSPGSAKGAPSVAAMVASVDSSLGQWPAEIRIQKEARKEMVDALDSMLKAHLRRWAANHKAAYPENIIVYRDGVSEGQYDHVTDEELPLLKNACKNIYPAPDTARNLPRFSIIIVGKRHHTRFYPTLQEDADRFNNPVNGTVVDRGITEARNWDFFLQAHTALKGTARPAHYYTVWDEIFLRQKVIPPAKNAADMLEAMTHHMCYLFGRATKAVSICPPAYYADLVCTRARCYLSSAFEPSTPSGSVIGAEDSTVKVANDDVLIHPNVRDTMFYI
Protein: Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) (Q96GX5)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20818157}. Nucleus {ECO:0000269|PubMed:19460416, ECO:0000269|PubMed:20818157}. Cleavage furrow {ECO:0000269|PubMed:20818157}. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. {ECO:0000269|PubMed:20818157}.
Interaction partners:
- Alpha-endosulfine
- cAMP-regulated phosphoprotein 19
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- G2/mitotic-specific cyclin-B1
- Cyclin-dependent kinase 1
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Cyclin-A2
- Kinesin-like protein KIF11
- Dual specificity protein kinase TTK
Sequence:
MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL
Protein: Probable pyridoxamine 5'-phosphate oxidase (G3XCV4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
Sequence:
MGVNANISESLTGTIEAPFPEFEAPPANPMEVLRNWLERARRYGVREPRALALATVDGQGRPSTRIVVIAELGERGVVFATHADSQKGRELAQNPWASGVLYWRESSQQIILNGRAERLPDERADAQWLSRPYQTHPMSIASRQSETLADIHALRAEARRLAETDGPLPRPPGYCLFELCLESVEFWGNGTERLHERLRYDRDEGGWKHRYLQP
Protein: GPI inositol-deacylase (EC 3.1.-.-) (F4IWG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU365011}.
Interaction partners:
- Peptidase C13 family
- GPI transamidase component family protein / Gaa1-like family protein
- GPI transamidase component Gpi16 subunit family protein
- GPI transamidase subunit PIG-U
- GPI transamidase component PIG-S-like protein
- GPI transamidase subunit PIG-U
- GPI mannosyltransferase 1
- Mannosyltransferase APTG1
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Sequence:
MVRSSKFSQEATLKRGESRENPTDLRSKLTNIYTIEMRDVRFAMSIRPRLRIVGVLILAAWIGLVALFGLLKPIKNGCTMTYMYPTYIPISVTDDTTPGRYGLYLYHEGWRKIDFKEHLKKLSGVPVLFIPGNAGSYKQVRSVAAESDRAFQGGPFERTFYQEASLLRGGGADTESVDYDLPSQYSNRLDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYKESHDTREREGAAASSKLPHDVILVGHSMGGFVARAAAVHPRLRKSAVQTILTLSSPHQSPPLALQPSLGHYFAQVNREWKKGYEVQTSPGGNYVSDPLLSGVVVVSISGGYNDYQVRSKLESLDGIVPSSHGFMISSTSMTNVWLSMEHQAILWCNQLVVQVSHTLLSMVDSKTNQPFSDTDKRLWVLTRMLQSALAQSFNGMTPMEVSHELPILASKGSTCFLDWRDDALDRDLYIQTSTVTILAMDGRRRWLDIDLLGSNGKNHFIFVTNLVPCSGVRLHLWPEKEKSNSNLPVCERVLEVTSKMVLIPAGPAPKQSEPGSQTEQAPPSAVLKLGPEDMRGFRFLTISVAPREAVSGKPPVAVSMAVGQFFNPGDGAVEVSSQSMLLSTYWAKEIFLKEDHPLAYNLSFSTSLGLLPATLSLKTTGCGIKTFGLPDGETGDLDKDKLCKLRCFPPVALAWDSASGLHVFANLYSETIVIDSSPALWSSQSSEKTTVMLLVDPHCSYTASVHVSAPAMSSRFVLLYGPQIVGFSFAVIMFALMRQANQWDNKLSVPPLLSAVEYNLEMPSPFLLLAVLPLISSLFYSFLMGQPIPPLTSFTVVSLICYLLANAFISVLTIVSKFPFQASALVHTTVKSRCQALERNYSLAFLHWFSILSSSFFCLKAIRILKLNTTILMTLIAVTLVSFVHPALGLFVLLASHALCCHNSMCCIMMASKRKESLDQKNEAERKTRHPSSREDPVSGDLSEKSFVETQADIFNHRHGLLILHLLAALMFVPSLAAWFQRIGTGQSFPWFADSALCVGVIFHGILNSRPESSILRSFPFFSGHQIRPHHIYLLAGYYCFFSGLELAPYKVFYAIASLGYISLTLKISQVNKNDLRFRTKSRIHRN
Protein: Exo/endonuclease G (H7C0W6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XFRSQGAEGALTGKQPDGSAEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAETFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGKKIVSYQSWEYPSLQF
Protein: Bifunctional polyhydroxybutyrate synthase / ABC transporter periplasmic binding protein (Poly-3-hydroxybutyrate synthase) (PHB synthase) (EC 2.3.1.-) (cPHB synthase) (P76108)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of short polymers of R-3-hydroxybutyrate (cPHB). Involved in natural transformation. Probably part of the ABC transporter complex YdcSTUV. During natural transformation, may bind dsDNA and convey it to the inner membrane channel formed by YdcV (Probable).
Subcellular location: Periplasm {ECO:0000269|PubMed:18640095}.
Interaction partners:
- Inner membrane ABC transporter permease protein YdcV
- Inner membrane ABC transporter permease protein YdcU
- Uncharacterized ABC transporter ATP-binding protein YdcT
- Gamma-aminobutyraldehyde dehydrogenase
- Putrescine transport system permease protein PotI
- Spermidine/putrescine transport system permease protein PotC
- 3-ketoacyl-CoA thiolase FadI
- 3-ketoacyl-CoA thiolase FadA
- Spermidine/putrescine transport system permease protein PotB
- Putrescine transport system permease protein PotH
Sequence:
MSKTFARSSLCALSMTIMTAHAAEPPTNLDKPEGRLDIIAWPGYIERGQTDKQYDWVTQFEKETGCAVNVKTAATSDEMVSLMTKGGYDLVTASGDASLRLIMGKRVQPINTALIPNWKTLDPRVVKGDWFNVGGKVYGTPYQWGPNLLMYNTKTFPTPPDSWQVVFVEQNLPDGKSNKGRVQAYDGPIYIADAALFVKATQPQLGISDPYQLTEEQYQAVLKVLRAQHSLIHRYWHDTTVQMSDFKNEGVVASSAWPYQANALKAEGQPVATVFPKEGVTGWADTTMLHSEAKHPVCAYKWMNWSLTPKVQGDVAAWFGSLPVVPEGCKASPLLGEKGCETNGFNYFDKIAFWKTPIAEGGKFVPYSRWTQDYIAIMGGR
Protein: Sin-like protein conserved region (Q386G3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQQTEKRVGGNCDDDEVIATYNVYASSFAQQQQQLHIFQFPLRCRARPYEANEVRLFATEGLIHSDEDSIANSGSRVGGTTASTPRQETFGAVAPVIHHSSRLTMHCHIDTFGSSSFTEPQQDHRLDEDTQRAEERSKHSYNYALQSHPFNPHCDYMVGLIVDGVVHITPVTSIQQFTPIVKPPDASSMHRVGDGFLSVPSVPIVPGLAVSDRITREMLRQRSVMLNNDADTAKELQYFPIQSVESMAMRRRLWDRTGASHCFAGPAGCVGSNPFGDSKDGHNNGPYVGPRTEDCFFPPELLVSGGITGGEHVVSGDKMLRRYANRRSLVDQVHIYLRRCQVLTLDKLREMVVPPDGAFSGGASSTNQSKVQESVTDGQLLAALRDGAIWMHGVWVSKVDPNMRGNAAALREVVLLHFCESPSGALSRARLNALVSSNTLKRTVKEILESIATLNSGEKDPALRVWRLRHVPADPMERAALLEVAQNAYRQEIEFQTMQCKRLHSSIMSHLEVINTGRLVTRLHFVSRGGDRGAEGPTGAVNTAVSTAAAAAATTVATSFTDNELAPIIAFIRRLFLEHGVVNKQRAKELVLKAKQQNYPHATNAMLSAALQRCVQPFTDATWVLKTLEEPDVDRHRPLILETALELVNFGIRPFNALLAQKQQQQQPDGETAGARKEDMQKVVSRVLAEIAVYQSHERLWHLKSGNVIGQ
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (G3V3R7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDL
Protein: Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) (Q3LIE5)
Organism: Homo sapiens (Human)
Function: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).
Interaction partners:
- Glycerol-3-phosphate acyltransferase 1, mitochondrial
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Ribose-phosphate pyrophosphokinase 3
- Ribose-phosphate pyrophosphokinase 2
- Ribose-phosphate pyrophosphokinase 1
- Glycerol-3-phosphate dehydrogenase [NAD
- ADP-sugar pyrophosphatase
- Phosphopentomutase
- Glycerol-3-phosphate dehydrogenase 1-like protein
- Glycerol-3-phosphate acyltransferase 4
Sequence:
MDDKPNPEALSDSSERLFSFGVIADVQFADLEDGFNFQGTRRRYYRHSLLHLQGAIEDWNNESSMPCCVLQLGDIIDGYNAQYNASKKSLELVMDMFKRLKVPVHHTWGNHEFYNFSREYLTHSKLNTKFLEDQIVHHPETMPSEDYYAYHFVPFPKFRFILLDAYDLSVLGVDQSSPKYEQCMKILREHNPNTELNSPQGLSEPQFVQFNGGFSQEQLNWLNEVLTFSDTNQEKVVIVSHLPIYPDASDNVCLAWNYRDALAVIWSHECVVCFFAGHTHDGGYSEDPFGVYHVNLEGVIETAPDSQAFGTVHVYPDKMMLKGRGRVPDRIMNYKKERAFHC
Protein: Peroxisomal membrane protein PEX29 (Peroxin-29) (Q03370)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the regulation of peroxisome number, size and distribution.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:12707309}; Multi-pass membrane protein {ECO:0000269|PubMed:12707309}.
Interaction partners:
- Peroxisomal membrane protein PEX30
- Peroxisomal membrane protein PEX31
- Peroxisomal membrane protein PEX32
- Protein YOP1
- Reticulon-like protein 1
- L-2-aminoadipate reductase
- Peroxisomal biogenesis factor 3
Sequence:
MDSVTNFFWNDTYNAGTPTRSTLKGKKVQNGIDGKSQAKKESISSGSRTSDPTRGSLPSSSGQPTSGGGFPSTSNIQKMMADTLVEKIIKMALPPSSKTAVDTIHHRMVAGKERPKLSVQITSRNFIQMNSRLGVPFMIMDELIKILNWTNPAYTVSIMFLYTLIILKPFQMLSSLPIFYLLFCVMVPQYLYIHKPNPTSYLDNNQTPAQGPPLRRPEVPKPVPELSQEFVLNLTDLQNHMLLYVKFYDFTLLILQKFAFFTNEAISSFYFIVLLIIATLNFLYMDKFIKLIPMRPVLILLGWGFFIASHPSNREYLLTKLNSEETRLKTLTISTNLESKILQHLKLIEAREHRLVMIFEIQKYLPEYKEWRPVGFSDDDYSLFSSLRIYQRRIEENSVKSLEEIEPPKDWEWEANSHWVLDLDPKEWVEDEFIQYVEIDSETKWVYDLNLDGQRGSYRRRMWTNSCVRKKLDSGISSNLGEEEVVNPLREETYRQGVHGVTKGSMSGGLTHSSDDDRADEESINGTIPNLNNIDADASYPSIEELTDTLNSTI
Protein: Tachykinin-3 (ZNEUROK1) [Cleaved into: Neurokinin-B (NKB) (Neuromedin-K)] (Q9UHF0)
Organism: Homo sapiens (Human)
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.
Subcellular location: Secreted.
Interaction partners:
- Neuromedin-K receptor
- Protachykinin-1
- Substance-K receptor
- Substance-P receptor
- Metastasis-suppressor KiSS-1
- KiSS-1 receptor
- Progonadoliberin-1
- Tachykinin-4
- Gonadotropin-releasing hormone receptor
- Proenkephalin-B
Sequence:
MRIMLLFTAILAFSLAQSFGAVCKEPQEEVVPGGGRSKRDPDLYQLLQRLFKSHSSLEGLLKALSQASTDPKESTSPEKRDMHDFFVGLMGKRSVQPDSPTDVNQENVPSFGILKYPPRAE
Protein: AGAMOUS-like protein 6 (MADS-box protein) (Q1PEU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRGRVEMKRIENKINRQVTFSKRRNGLLKKAYELSVLCDAEVALIIFSSRGKLYEFGSVGIESTIERYNRCYNCSLSNNKPEETTQSWCQEVTKLKSKYESLVRTNRNLLGEDLGEMGVKELQALERQLEAALTATRQRKTQVMMEEMEDLRKKERQLGDINKQLKIKFETEGHAFKTFQDLWANSAASVAGDPNNSEFPVEPSHPNVLDCNTEPFLQIGFQQHYYVQGEGSSVSKSNVAGETNFVQGWVL
Protein: RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51) (A6NDU8)
Organism: Homo sapiens (Human)
Function: Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A. Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:34432599}.
Interaction partners:
Sequence:
MAAAVSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSSQKVKELISFLSEPEILVKENNMHPKHCNLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSSLLKKYLLDGISYLLQMLNYRCPIQLNEGVSFQDLDTAKLLSAGIFSDIHLLAMMYSGEMCYWGSKYCADQQPENHEVDTSVSGAGCTTYKEPLDFREVGEKILKKYVSVCEGPLKEQEWNTTNAKQILNFFHHRCN
Protein: Probable S-adenosylmethionine-dependent methyltransferase Rv3030 (EC 2.1.1.-) (P9WJZ1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O-methylglucosyl lipopolysaccharides (MGLP).
Interaction partners:
- Glycogen synthase
- Probable 1,4-alpha-glucan branching enzyme Rv3031
- Probable acetyltransferase Rv3034c
- Diglucosylglycerate octanoyltransferase
- Glucosyl-3-phosphoglycerate synthase
- Uncharacterized S-adenosylmethionine-dependent methyltransferase Rv3037c
- Glucosyl-3-phosphoglycerate phosphatase
- Electron transfer flavoprotein subunit beta
- Conserved protein
- Electron transfer flavoprotein subunit alpha
Sequence:
MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP
Protein: Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) (Serine/threonine-protein kinase 22E) (Q6SA08)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D411}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D411}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250|UniProtKB:Q9D411}.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 1
- Testis-specific serine kinase substrate
Sequence:
MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQPTHEIRLLEAMCQLHNTTKQHQSLQITT
Protein: Kinesin-like protein KIN-12A (OsKinesin-12A) (Phragmoplast-associated kinesin-related protein 1) (OsPAKRP1) (Q7XKR9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis.
Subcellular location: Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:10898978, ECO:0000269|PubMed:19106179}. Note=Localized to the midline of the nascent phragmoplast (late anaphase) essentially at the plus end of phragmoplast microtubules. {ECO:0000269|PubMed:19106179}.
Interaction partners:
- Kinesin-like protein KIN-10A
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase
- Kinesin-like protein KIN-1
- Kinesin-like protein KIN-14I
- Kinesin-like protein KIN-UA
- Kinesin-like protein KIN-UB
- Kinesin-like protein KIN-14O
- Kinesin-like protein KIN-10C
- Kinesin-like protein KIN-7G
Sequence:
MSTTLRRAWSSLNGNDGVLPYFLATLNEVSLLQARPPPGHAAAALALRRRRRDTPPSRRRVPKENVDPGSSPAGHSPFRSPTSSAKPLGNRNRGLLPPRPPSSNPLKRKLDVSPAAAADSSGGAAAAAAAAGGGCPAPDSGVQVVVRIRPPCRVEEEEDARAPDLCVRKTATNSVAIQGQDFTFDAVADEVSTQEDIFKLVGLPLVENCLSGFNSSIFAYGQTGSGKTYTMWGPLSALSEDSTCSERGLTPRVFEQLFSRIKEEQGKHEDKELTYHCVCSFLEIYNEQITDLLDPSPKSLQIREDVRTACVYVESLTKELVFTTKDVTQLLVKGLSNRRTGATSANADSSRSHCVFTCVIKSESKNLEDGSNSTRTSRINLVDLAGSERQKLTHAFGDRLKEAGNINRSLSQLGNLINILAEISQSGKQRHVPYRDSKLTFLLQESLGGNAKLAMICAVSPSQSCKSETLSTLRFAQRAKSIKNNAVVNEQKEEDVNMLREQIRQLKDELHRMKSGGSDGSNGSFSTGWNARRSLHLLKMSLSRPTTFQTIHEDSGDVEMEIDENDVEKPYNQDNMVISPPGDKECKELQASLKINGGTSLDVFDGENLMPTKRSCSDDRYKLNLAASIQRGLQVIENHQNNGAWRRASVGFNARIVDVQPCKVDVAIQTEPEESEARDNPLALISSHVLGTSATVSNDPNACRDLQLVQYDAGITRDEPKQQQILKAVEKVLAGAIRREMARDEQCVKQAAEIQQLNRLVQQYKHERECNAVIAQTREGKIARLESLMDGTLPTEEFINEEYLSLMNEHKILQQKYENHPELLRAEIELKRLQEELELCRNYIDEKEVLQEEIQDLKSHLHFMLSSSASIRRLWPPVQLSHGVGPSPVTNDADGDNNAVDTPDWAEAESKWVTLTEELRVELEANKSLVGRLRSELESEKKCSEEVKEALQTAMQGHARILEQYAELEERHIGLLAMHRKIREGVEDVKARAAKAGVKGAELRFINSLAAEMAVLRAENKGLQDQLGDTAEAVQAAGELLVRLKEAEEAEALAQRRALLAEQETEKAYQEIDNLKKNYDQEIVALNQRLSESSHHQETTLAIEACDMETTKYDTAGSPGDQQWREEFNQQGGSFEVSKSTDLNSWFSGYDKCNI
Protein: Disintegrin and metalloproteinase domain-containing protein 32 (ADAM 32) (Q8TC27)
Organism: Homo sapiens (Human)
Function: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSSSN
Protein: Oxygen-evolving enhancer protein 2, chloroplastic (OEE2) (23 kDa subunit of oxygen evolving system of photosystem II) (23 kDa thylakoid membrane protein) (OEC 23 kDa subunit) (P12302)
Organism: Spinacia oleracea (Spinach)
Function: May be involved in the regulation of photosystem II.
Subcellular location: Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Interaction partners:
Sequence:
MASTACFLHHHAAISSPAAGRGSAAQRYQAVSIKPNQIVCKAQKQDDNEANVLNSGVSRRLALTVLIGAAAVGSKVSPADAAYGEAANVFGKPKKNTEFMPYNGDGFKLLVPSKWNPSKEKEFPGQVLRYEDNFDATSNLSVLVQPTDKKSITDFGSPEDFLSQVDYLLGKQAYFGKTDSEGGFDSGVVASANVLESSTPVVDGKQYYSITVLTRTADGDEGGKHQVIAATVKDGKLYICKAQAGDKRWFKGAKKFVESATSSFSVA
Protein: Transcription factor bHLH90 (Basic helix-loop-helix protein 90) (AtbHLH90) (bHLH 90) (Transcription factor EN 50) (bHLH transcription factor bHLH090) (Q0WNR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH10
- B3 domain-containing protein At5g25475
Sequence:
MMMMRGGERVKEFLRPFVDSRTWDLCVIWKLGDDPSRFIEWVGCCCSGCYIDKNIKLENSEEGGTGRKKKASFCRDDHNKHRIRTLACEALSRFPLFMPLYPGIHGEVVMSKSPKWLVNSGSKMEMFSTRVLVPVSDGLVELFAFDMRPFDESMVHLIMSRCTTFFEPFPEQRLQFRIIPRAEESMSSGVNLSVEGGGSSSVSNPSSETQNLFGNYPNASCVEILREEQTPCLIMNKEKDVVVQNANDSKANKKLLPTENFKSKNLHSERKRRERINQAMYGLRAVVPKITKLNKIGIFSDAVDYINELLVEKQKLEDELKGINEMECKEIAAEEQSAIADPEAERVSSKSNKRVKKNEVKIEVHETGERDFLIRVVQEHKQDGFKRLIEAVDLCELEIIDVNFTRLDLTVMTVLNVKANKDGIACGILRDLLLKMMITSI
Protein: CRAL-TRIO domain-containing protein (Q584J9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- C-type lectin domain-containing protein
Sequence:
MSTHEVDVLLSHLGYEATTHRKQLQDLKNRIGIAHTHFDCWLYAFLESKDFNVPETIRIVEERETMERTELCNYTDVDTDIHSELARGVVQIIGSDRLGRVCLYVCTARYATGVKNHSEYVKMLDVVMTYATRLREENKSCRVILLIDQQNAEVLKSMELCFQKTVATRISRFYPGLIERVFIVNMSKIAAVVARPLLNRALKDISGSIVVVSEAELRRGFLLQWFDQAVLPTELGGELNTVEPARWRAFADAVTCHFCELQKAIKQDNLTVKEWELQQLQLRAAGRQLQCKDGEAEPFGDITKARHEYGDRHERGNRSYAEEQYHLMRNYCSVRDEIIKVELIKRNLVLRSMSGCCKDGEQTCHYFREKYRKVKRHLAEEKHYLFYVKIAAGVAAAILLAAVFFVCRVTLIWWDWVLREDITTLIIAVVAGAFSAVHLPWGMNV
Protein: Small ribosomal subunit protein uS19m (40S ribosomal protein S19, mitochondrial) (P39697)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The RNA-binding domain found in RPS19 may functionally replaces the missing mitochondrial RPS13.
Subcellular location: Mitochondrion {ECO:0000303|PubMed:36423343}.
Interaction partners:
- Small ribosomal subunit protein uS13m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS14m
- Ribosomal protein S12
- Small ribosomal subunit protein uS7m
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein uS2m
- Large ribosomal subunit protein uL2mz, N-terminal part
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein bS18c
Sequence:
MAFCTKLGGHWKQGVNVPVSSMLGSLRYMSTKLYIGGLSPGTDEHSLKDAFSSFNGVTEARVMTNKVTGRSRGYGFVNFISEDSANSAISAMNGQELNGFNISVNVAKDWPSLPLSLDESIEEAEKKENKMMSRSVWKDPFVDAFLMKKKNAALNRKIWSRRSTILPEYVDSAVRIYNGKTHVRCKITEGKVGHKFGEFAFTRKVKKHAKAK