wanglab/gogpt-training-data huggingface dataset:
Protein: GH08941p (Quasimodo, isoform A) (Quasimodo, isoform B) (Q7K3W4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH09711p
- Sodium chloride cotransporter 69, isoform E
Sequence:
MLLSMQMWRSLWLAALFCGLAQAKGSHKVHCSEDQMRVDIGLPDAESKDQSAPQIYLEGLKGYPDERCQPQIDGSLAVFRLSLSDFYECGVTRMVNQLTGKKVYYHKIIIESTSGKEIVSVKCITTASPAYNVMMNATTGSSSTSTSSGGIHGLVKRDVLPAGFQEPEDLEITTSLTKRAPEPRLSIGVSQDGQKFTRDLTVKSGTPLTMEINLDEDSAPVYGLGVNYLDVTDTHTSSETLIFKGCTVDPYLFENFNTIDGDILSAKFKAFKFPDSSYVQFRATVNVCLDKCLGTQCSNNQVGFGRRKREISSANKVYEISLAMFLQVQDIEGVNKNEVLQLEEKLRELKLANQRLARNSRGNFAMEQTPASAQPAFVVDERELGHLSAGSGAASNGLSLALWTILGAWSWRLM
Protein: Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) (Q97NE3)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02006}.
Interaction partners:
Sequence:
MHIFDELKERGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSLHLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQGQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIETGISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVITVPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAVRFLKIFTFLSLDEIEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKELKQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQELDYVLSDADKLENELTVIRRGKKKYFVLTY
Protein: Probable diguanylate cyclase DgcE (DGC) (EC 2.7.7.65) (P38097)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of c-di-GMP (Probable). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Flagellar brake protein YcgR
- Cyclic di-GMP phosphodiesterase PdeR
- Cyclic di-GMP phosphodiesterase PdeH
- Probable cyclic di-GMP phosphodiesterase PdeD
- Probable diguanylate cyclase DgcQ
- Oxygen sensor protein DosP
- Cyclic di-GMP phosphodiesterase PdeL
- Aerobic respiration control sensor protein ArcB
- Probable cyclic di-GMP phosphodiesterase PdeK
- Signal transduction histidine-protein kinase BarA
Sequence:
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRHAGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQNLADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPHYLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISESETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLVNDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGEVIADAQPLDLLVNSSYFAIN
Protein: ATP-dependent helicase/deoxyribonuclease subunit B (EC 3.1.-.-) (ATP-dependent helicase/nuclease subunit AddB) (P23477)
Organism: Bacillus subtilis (strain 168)
Function: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent single-stranded exonuclease, acting in both directions. Recognizes the B.subtilis chi site (5'-AGCGG-3') which transforms the enzyme from a helicase which degrades both DNA strands to one with only 5' to 3' exonuclease activity. This generates a double-stranded DNA with a protruding 3'-terminated single-stranded tail suitable for the initiation of homologous recombination (chi fragment). The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. RecA thread formation during DNA double-strand break repair requires RecJ or AddAB.
Interaction partners:
- ATP-dependent helicase/nuclease subunit A
- Nuclease SbcCD subunit D
- Nuclease SbcCD subunit C
- DNA replication and repair protein RecF
- DNA repair protein RecN
- Probable ATP-dependent DNA helicase RecS
- DNA repair protein RecO
- Recombination protein RecR
- Single-stranded-DNA-specific exonuclease RecJ
- Holliday junction resolvase RecU
Sequence:
MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMTFLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEEHKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSEKLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEFRVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYKELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHALVREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLDVLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQYRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRYLEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQQMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVLSDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPSMIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDISDVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETFNACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQCELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGLELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLAEVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQEIFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLLTKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKAEKDKTILEWIKKEADGNEHS
Protein: Protein LDB17 (Low dye-binding protein 17) (Q12342)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Bud {ECO:0000269|PubMed:14562095}. Bud neck {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 3
- Protein BZZ1
- Actin-related protein 2/3 complex subunit 1
- Actin-related protein 2/3 complex subunit 3
- Protein YSC84
- Actin cytoskeleton-regulatory complex protein SLA1
Sequence:
MILDPLSPNIENHTQDEIIEFWEKTESIANIPKENLDESHVNSSLVAYLKFATDSYKVFINTDRDLYRMSLILLESSLFEFKKEFCLSKLQSLLNIDLLEMNMKFIIVYILLCEAKKNVYSLEIMLKFQGFTVFYNTLYTQFAYLSKYGKERTVASKHQYNSNNSSTGTSLDSLDRSLTDIDLGIIDEMKQISTVLMDLLFQIMKYCKCVIANLQIVDDFFVYYMMESMRSDTMDDMFNNAEFKLLLALNEQYMMFAKEYDIENKVYKYLINGSVSRCFTELLLLKFNRASDPPLQIMMCKIIYLILTPRGDYSPMNFFYTNDLRVLIDVLIRELQNISEDEEVLRNTLLRVLIPLLKNTQLSKTHYRKDDLNKLLNYLSTLDNICVDSPALHEHQVTVALSRKCLQQIPWLETPSTPSDGGSSVSSNNTSRNSSIVALGTPDNQNILARKGHLYSNRELDVSAESLTKRKAKAPPPPPPPPPSRKCGTPK
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (Q6DRL1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADMQMKILRKKIQKISEKNKQRKLLQSQKEEENSEEVKDVLDESEVASDSAPNVIEEQQQSVSDEVNETSQKPKKKKKKRKLDATGESTTSSVKKAKKQSVDTTQASAGEEEQQEEGNLETVKCPENGNNEKEGSAEEDSDEDGPQLPSGLTGAFEDRSFASLSEVVSENTLKGVKEMGFDTMTEIQHKTIRPLLEGRDVLAAAKTGSGKTLAFLIPSIELIYKLKFMPRNGTGVIVLSPTRELAMQTYGVLKELMTHHVHTYGLIMGGSNRSAEAQKLANGVNILVATPGRLLDHLQNTPGFMFKNLQCLIIDEADRILEVGFEEELKQIIKLLPKKRQSMLFSATQTRKVEDLARISLKKEPLYVGVDDNKDTATVEGLEQGYVVCPSEKRFLLLFTFLKKNRKKKLMVFFSSCMSVKFHYELLNYIDLPVMAIHGKQKQTKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQFDPPDDPKEYIHRVGRTARGINGRGHALLILRPEELGFLRFLKQAKVPLSEFEFSWTKISDIQSQLDKLIEKNYYLHKSAQEAYKSYVRAYDSHSLKQIYNVETLDLPKVAMSFGFKVPPFVDLNVHSSKGVKLHKRGGGGGFGYQKSKNVHKAKIFKHVNKGKGDGRQFSR
Protein: Metal tolerance protein 12 (AtMTP12) (Q9SI03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
Subcellular location: Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Tonoplast.
Interaction partners:
- Metal tolerance protein C1
- Metal tolerance protein C4
- Metal tolerance protein C2
- Metal tolerance protein 9
- Metal tolerance protein 11
- Putative metal tolerance protein C3
- Metal tolerance protein 10
Sequence:
MESPESFSTMFMKPIRHILSEKKSRKIALFLLINTAYMVVEFVAGFMSNSLGLISDACHMLFDCAALAIGLYASYISRLPANHQYNYGRGRFEVLSGYVNAVFLVLVGALIVLESIERILDPQEISTNSLLVVSVGGLLVNIVGLIFFHEEHHHAHGGSGIFLHVLADTMGSVGVVISTLLIKYKGWLVADPASSIFISILIIASVIPLLRNSAEILLQRVPRAHRQDLKEAMRNILKTKGVCSIQRLHVWSFTNSDVVATLHLLVSADSDKTDTKLQVSRLLEDAGVKDWTLQVESVNS
Protein: Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) (O42123)
Organism: Xenopus laevis (African clawed frog)
Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MGVQVETITEGDGRTFPKKGQTVVVHYVGSLENGKKFDSSRDRNKPFKFIIGRCEVIRGWEEGVAQMSVGQRARLTCSPDFAYGATGHPGIIPPNATLTFDVELLRLE
Protein: Adapter SH3BGRL (SH3 domain-binding glutamic acid-rich-like protein 1) (O75368)
Organism: Homo sapiens (Human)
Function: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:34870550, ECO:0000305|PubMed:34331014}. Cell membrane {ECO:0000269|PubMed:32381043}.
Interaction partners:
- Non-histone chromosomal protein HMG-14
- Cyclic nucleotide-gated channel beta-1
- Epidermal growth factor receptor
Sequence:
MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
Protein: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.47) (Ceramide UDP-galactosyltransferase) (Cerebroside synthase) (UDP-galactose-ceramide galactosyltransferase) (Q16880)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q09426}.
Interaction partners:
- Ceramide glucosyltransferase
- Galactocerebrosidase
- Galactosylceramide sulfotransferase
- Ceramide kinase
- Arylsulfatase A
- Ceramide synthase 2
- Acid ceramidase
- Sphingosine-1-phosphate phosphatase 1
- Sphingomyelin phosphodiesterase 2
- Ceramide synthase 4
Sequence:
MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK
Protein: CRM-domain containing factor CFM3, chloroplastic/mitochondrial (Protein CRM FAMILY MEMBER 3) (OsCFM3) (Q2R1U8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Binds specific group II introns in chloroplasts and facilitates their splicing. Acts on subgroup IIB introns. The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3 and CAF1 or CAF2. May influence the biogenesis of the mitochondrial small ribosomal subunit (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18799595}. Mitochondrion {ECO:0000269|PubMed:18799595}.
Interaction partners:
Sequence:
MAAAAMAISPSIHLHLHLHLHHPPRLHRLLHLSTTSPYPWLSAWPTAHRRRVPLRRPASALDLRPEPSPSSDSDDDAAFGTSRSSSRSAMSLILSRLRNSGYSYSPPELPPRPPRGSVEDVFRVDDGVVPNARGGFDDDAESALVDARFPWELPMPPPEAGPRAARSKAWMAELTLPEAELRRLRHAGMRLKSRIKVGGAGVTREIVERIRDRWRNDEVVRIKVTGTPALNMRLFHEILERKTGGLVIWRSGTSVSLYRGVAYDIPEPTKGTSKNTQTLGMKSSIKEPPGHSLLPNEKVNEMQDNNGALVSNAEKDTLVEPVPEIKYEDEIDKLLDELGPRYDDWPRPDPSPVDADLLPATVPGYKPPFRVLPYGVRPSLSRRDTTNLRRLARGLPPHFALGRSRQLQGLAAAMVKLWEKSSIAKIALKRGVQLTTSERMAEDIKKLTGGVMLSRNNDFMVFYRGKDFLSPELAEKLLERERWAKSLQDEEQARLNAASSFSSRTEAPVEPTVAGTLGETLEANSKYGNKLDENYENKMTRTVEAARHADLVRKLEWKLQLAQKKIEKAERVLGKVETALKPTEGIQPPETITDEERFMFRKLGLRMKAFLLLGRRGVFDGTIENMHLHWKYRELVKILVKAKSFGDVKKIALSLEAESGGILVSVDKVSKGYAIVVFRGKDYARPSKLRPRNLLSKRKALARSIEIQRREALSHHIATLNRRVKKLKAELLQMEGVKEEGDVELYAKLDSAYSSDEEDVEDEDDEAYLRSFDNSVAVQNGDDRTSLDGSDANSDDEGDYSDEDDDEDDDNDEEDGFDYENDDEDDVPPTTSDGDLYNHTDFGSSDSENYVSLSGRGDPDVKSKGSALDSRNSYSEQSTELTNTCS
Protein: 26S proteasome regulatory subunit RPN9 (Proteasome non-ATPase subunit 7) (Q04062)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- Proteasome subunit alpha type-4
- 26S proteasome subunit RPT4
- 26S proteasome regulatory subunit RPN8
- 26S proteasome complex subunit SEM1
- 26S proteasome regulatory subunit RPN3
- 26S proteasome regulatory subunit RPN5
- Ubiquitin carboxyl-terminal hydrolase 6
- Proteasome subunit beta type-4
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN12
Sequence:
MFNNHEIDTILSTLRMEADPSLHPLFEQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQLSVVKYLLASLKDSKDFDESLKYLDDLKAQFQELDSKKQRNNGSKDHGDGILLIDSEIARTYLLKNDLVKARDLLDDLEKTLDKKDSIPLRITNSFYSTNSQYFKFKNDFNSFYYTSLLYLSTLEPSTSITLAERQQLAYDLSISALLGDKIYNFGELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKFDSLIKVQISKIPILAQHESFLRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAISLGLLKGSIDQVNELVTISWVQPRIISGDQITKMKDRLVEWNDQVEKLGKKMEARGQSIWV
Protein: Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) (Q9CZW5)
Organism: Mus musculus (Mouse)
Function: Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (By similarity). Mediates TBK1 and IRF3 activation induced by MAVS in response to virus infection and promotes host antiviral responses during virus infection.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O94826}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial import receptor subunit TOM20 homolog
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM5 homolog
- Mitochondrial import receptor subunit TOM6 homolog
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Mitochondrial antiviral-signaling protein
- Mitochondrial import receptor subunit TOM40B
Sequence:
MAASKPIEAAMAAAAAPGSGNGVGGGGGTAGPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSRRRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGHHDGSGDSLEMSSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLSTQDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQAYTANNSSQVQAAMKGFEEIIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL
Protein: Non-SMC condensin I complex subunit D2 (E7EN77)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMI
Protein: glutathione transferase (EC 2.5.1.18) (C8BLR4)
Organism: Meleagris gallopavo (Wild turkey)
Interaction partners:
Sequence:
MAEKPKLHYTRGRGKMESIRWLLAAAGVEFEEEFIEKKEDLEKLRNDGSLLFQQVPMVEIDGMKMVQTRAILCYIAGKYNLYGKDLKERAWIDMYVEGTTDLMGMIMALPFQAADVKEKNIALITERATTRYFPVYEKALKDHGQDYLVGNKLSWADIHLLEAILMTEELKSDILSAFPLLQAFKGRMSNVPTIKKFLQPGSQRKPPLDEKSIANVRKIFSF
Protein: carnosine N-methyltransferase (EC 2.1.1.22) (Q584B2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- MIF4G domain-containing protein
Sequence:
MLGDDRYPGPPPPYPHDPGLDFCYDSACPPHGQLPWSDQSPSGDREMRDDHISFMRTVKAFREYIKYAMSSREARLASFNKFNNEYREVLCIDLEATFGKYAKCIEANSEFFECICDASKGLFDAYWPNGTTVTPEEVPPPTPLDIDKVFSTLRQFVRDWSAEGAAERDAVYKPMLQTLEEHFPDVSRRSGVQILVPGAGLCRLVVELALRGFSAQGNEFSYHMLIAAHYIQNHVVAPGQHTIFPYVDNTCNLVERDHQFVELNIPDLCASEEVGRRSQQPYSFGELSMVAGDFTEVYAKGSQLKKWNAVVTCFFIDTAHNIVEYIKILYNLLVPGGIWVNCGPLLYHFAGNAEGDSIELSLSEVLTVAMRFGFVVRRDPILIDTTYTNNYRSMKQLLYRCAFFVLQRPPVDTREAA
Protein: Auxin-responsive protein IAA5 (Auxin-induced protein AUX2-27) (Indoleacetic acid-induced protein 5) (P33078)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 5
- Auxin response factor 7
- Auxin response factor 16
- Auxin transporter protein 1
- Auxin-responsive protein SAUR15
- Auxin response factor 19
- Auxin response factor 22
- NAC domain-containing protein 71
- Putative auxin response factor 14
Sequence:
MANESNNLGLEITELRLGLPGDIVVSGESISGKKRASPEVEIDLKCEPAKKSQVVGWPPVCSYRRKNSLERTKSSYVKVSVDGAAFLRKIDLEMYKCYQDLASALQILFGCYINFDDTLKESECVPIYEDKDGDWMLAGDVPWEMFLGSCKRLRIMKRSCNRG
Protein: Putative quercetin 2,3-dioxygenase Rv0181c (Putative quercetinase) (EC 1.13.11.24) (Pirin-like protein Rv0181c) (P9WI85)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Putative quercetin 2,3-dioxygenase.
Interaction partners:
- Probable conserved transmembrane protein
- Monoacylglycerol lipase
- Uncharacterized protein Rv0887c
- ECF RNA polymerase sigma factor SigG
- Uncharacterized protein Rv0942
- Probable conserved transmembrane protein
- Conserved protein
- Possible lipoprotein LprO
Sequence:
MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAALTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLGDSAT
Protein: Glycine hydroxymethyltransferase (Serine methylase) (G3V3Y8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPD
Protein: Uncharacterized protein (G5EAY9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Nucleoporin NSP1
- Peptidase S59 domain-containing protein
- mRNA export factor MEX67
- WD40 protein related to S. cerevisiae SEH1
- Nuclear pore complex protein An-Nup170
- Nuclear pore complex protein An-Nup159
- Nuclear pore complex protein An-Nic96
- Nuclear pore complex protein An-Mlp1
- mRNA export factor GLE1
- Nuclear pore complex protein An-Nup49
Sequence:
MSGLFGATANTSTAASNTTGDISKDVALNSPPEDSISDLRFSPASEHLAVASWDKKVRIYEINEQGQSEGKALFEHEAPVLNCCWSPDGTKVVGAGADKAARMLDLAANATAPIQVAAHDAPIRCCHMIPNPAGGTPLLVTGSWDKQVKYWDLRQSTPIASLECQERVYTMDVKDKLLVIGTADRYINIVDLNNPTKFYKTMQSPLKWQTRVVSCFTDANGFAVGSIEGRCAIQYVEDKDSSSNFSFKCHRETPPNQRDINNIYSVNAISFHPVHGTFSTAGADGTFHFWDKDAKHRLKGYPSVGGTISSTAFNRTGNIFAYAVSYDWSKGYSANTPQLPNKVMLHPVAQEEVKPRQNARRR
Protein: GTP-binding protein, putative (Q57TZ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Ribosomal protein L11, putative
- Large ribosomal subunit protein bL21m
- EngB-type G domain-containing protein
- 50S ribosomal protein L13, putative
- Pseudouridylate synthase RPUSD4, mitochondrial
- tRNA/rRNA methyltransferase SpoU type domain-containing protein
- GTP-binding protein, putative
- Acyl carrier protein
- Large ribosomal subunit protein uL3m
Sequence:
MRRCIPASVLRRVLLLQTRLVSTNTQTPPSGCATKIQNESPMNGSFNLPRERQILGGLHADWRTQMKRSGSILNDITPALPDTKRTEEQRRRVAGWRPVVKLLGDQRLRIAIVGRMNSGKSSLFNLLRLEPTVPGRSNVVRDFDGITRDSVEGQAQLEGMHFTIIDTPGMVQGRMVEEAFRTVETADAAIFVTAVDEDIMPEELSLMQYLHLKHMPVVLLANKMDLIQEEEEEAVLDRYNSLGFGNAIPFSARRKSGLEMLAAVLEPLYHIHAMHKVENDWDIEDLAMQGDESAMEEIRERNCSDRFIRIAIVGRTNSGKSSLVNRLVGFERNRAVDEKNSTRDPVELPCSYKGRKLKLIDTAGLARHRYRADRDFIGRIHGLSVNEIRFAHVVIVVFDATEGHPNKYDMAVLHSVAAEGRPFLLCANKWDAVLDQSATAEAIDFKIKRQVREVKYSNAVVVSAHTGLNLTLLMDQALELYDKWNKRVRRAELTRLWRKMEKSVIIPYHVARIGRITQVNTRPPTFLLQLQTKNDSNTLPKALQEMMKNTLVEEFDFRGVPIRLIQEVKDSNPDYI
Protein: Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (P07483)
Organism: Rattus norvegicus (Rat)
Function: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
Subcellular location: Cytoplasm.
Interaction partners:
- Gastrotropin
- Fatty acid-binding protein, liver
- Fatty acid-binding protein, adipocyte
- Fatty acid-binding protein 5
- Fatty acid-binding protein, brain
- Aspartate aminotransferase, mitochondrial
- Platelet glycoprotein 4
Sequence:
MADAFVGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDTITIKTHSTFKNTEISFQLGVEFDEVTADDRKVKSVVTLDGGKLVHVQKWDGQETTLTRELSDGKLILTLTHGNVVSTRTYEKEA