wanglab/gogpt-training-data huggingface dataset:
Protein: Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (Q9EPI1)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q86Y38}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Xylosyltransferase 2
- Syndecan-1
- Hexosyltransferase
- Exostosin-like 2
Sequence:
YFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPLSRQKERLQRKLGAQDKGQGQSVLGKGPKEVLPPREKAPGNSSQGKDLSRHSHSRKSGGGGSPETKSDQVPKCDISGKEAISALTRAKSKHCRQEIAETYCRHKLGLLMPEKVARFCPLEGKANKNVQWDEDAVEYMPPNPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSRQYDNVRVTSWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQDLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLRSYWENVYDEPDGIQSLSDVALTMYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHVTNLAVSKLETLETWMMPKKVFKVASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNKQPIKPEEALKLHNGPPRSAYMEQSFQSLNPVLSLHINPAQVEQARKNAAFTGTALEAWLVGGTWTAMDVCATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR
Protein: Store-operated calcium entry-associated regulatory factor (Transmembrane protein 66) (A0A140VK59)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
Sequence:
MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR
Protein: Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (Protein enhancer of sevenless 3B) (Q24276)
Organism: Drosophila melanogaster (Fruit fly)
Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Heat shock protein 83
- Heat shock protein 83
- Stress-induced-phosphoprotein 1
- protein-serine/threonine phosphatase
- cyclin-dependent kinase
- Heat shock protein 75 kDa, mitochondrial
- DnaJ-like-2, isoform A
- Raf homolog serine/threonine-protein kinase Raf
- Serine/threonine-protein kinase Pink1, mitochondrial
- Cyclin-dependent kinase 9
Sequence:
MVDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVKERISKKDGDEEALKKELEKIEAEGKELDRIESEMIKKEKKTPWNVDTISKPGFEKTVINKKAGRKPDENLSEEEREQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKERLGPGGLDPADVFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLWVPNAADLEGDKKEEDDSDDVAGGEEKTDDAKSESAAKEEPIYTGVSTEDVD
Protein: Lipophorin receptor 2, isoform A (Q9VBN2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MATTCMPHFTEYFQTTTQSELTTNESANSRSSSSSSGCREPSKTSGFFYSASTHYQSKVQQLISFSFTSSFHLLFITCILSISKFCNAAAVNAAHVTAATPTASEIMHNLSGSALLERLKASTLGPTLDQLKHLAPAAANSISPGTGSGMGIGMGHFGSSINSVLNGNPLKFLNVSGKIGTPLDISLGLSNYCDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRGLCSSLMFMCKNGEQCIHREFMCDGDQDCRDGSDELECGNRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLETKTGNNRTDTSNQVHKSDAESENDYVEIALHVIASLAGTALVASVIYVVYRRCTRAVNSMNFENPVYHKTTEDHFSLEKNGTPHIYAAANDEEAVNPLFKSGTECV
Protein: Protein C-ets-1 (p54) (P41156)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P14921}. Cytoplasm {ECO:0000250|UniProtKB:P14921}.
Interaction partners:
- Runt-related transcription factor 1
- Mitogen-activated protein kinase 1
- Paired box 5
- Mitogen-activated protein kinase 3
- ETS proto-oncogene 2, transcription factor
- Forkhead box protein O1
- Runt-related transcription factor 2
- Serum response factor
- Core-binding factor subunit beta
- Paired box 2
Sequence:
MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKECFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPTYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQTDYFAIKQEVLTPDNMCMGRASRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE
Protein: Nuclear division defective protein 1 (Q08887)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription activator involved in G2/M transcription through its association with FKH2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:10207056}.
Interaction partners:
- Fork head protein homolog 2
- Fork head protein homolog 1
- Pheromone receptor transcription factor
- Cyclin-dependent kinase 1
- Metallothionein expression activator
- Forkhead transcription factor HCM1
- G2/mitotic-specific cyclin-2
- Regulatory protein SWI4
- Transcriptional factor SWI5
- Regulatory protein SWI6
Sequence:
MDRDISYQQNYTSTGATATSSRQPSTDNNADTNFLKVMSEFKYNFNSPLPTTTQFPTPYSSNQYQQTQDHFANTDAHNSSSNESSLVENSILPHHQQIQQQQQQQQQQQQQQQALGSLVPPAVTRTDTSETLDDINVQPSSVLQFGNSLPSEFLVASPEQFKEFLLDSPSTNFNFFHKTPAKTPLRFVTDSNGAQQSTTENPGQQQNVFSNVDLNNLLKSNGKTPSSSCTGAFSRTPLSKIDMNLMFNQPLPTSPSKRFSSLSLTPYGRKILNDVGTPYAKALISSNSALVDFQKARKDITTNATSIGLENANNILQRTPLRSNNKKLFIKTPQDTINSTSTLTKDNENKQDIYGSSPTTIQLNSSITKSISKLDNSRIPLLASRSDNILDSNVDDQLFDLGLTRLPLSPTPNCNSLHSTTTGTSALQIPELPKMGSFRSDTGINPISSSNTVSFKSKSGNNNSKGRIKKNGKKPSKFQIIVANIDQFNQDTSSSSLSSSLNASSSAGNSNSNVTKKRASKLKRSQSLLSDSGSKSQARKSCNSKSNGNLFNSQ
Protein: Oskar (A1Y1T7)
Organism: Drosophila immigrans (Fruit fly)
Interaction partners:
Sequence:
MATFRSEFNSVPNTHPDRLTAFRKKLTTCFHQWRQKLQHFKHDYSTLRAKSICWQKFKKIYTATKLISQEEVEEQQLQIVATLFSSTLISKYTSSKNSSSCNMTIMDDSYIGVRDEYPDIDAEIRAILLANAQKGITISSIKSEYRNMTGNAFPLRENITDFLLTIPYVTAECCMSGKRIFNIKPTEDTRHLHDMVLNQRQRENGNNHNSNNHHVLDAQEPPRLWRSQYKRRCLQNENYNFNLNICEKPPAAKITPVQHLATAAMAPFGVYQDNWKHLNNQYQLSQLATQNSNQFSCIRSDPVQLQIAPHPPEQQHQQQRQQQQQQIGEYSHKRRHEFTPTPTTLSCPSQHDSMFTINSDYDAYLLDFPLLGDDFFLYLARMELKCRFKKDEKVLQSGLCISGQTINAARQRVQHVELQEMTQIIVNIGSVDIMRGKPLVQIEHDFRQLIKEMHNRRFVPVLTTLAPLANYCHDKQTCEKVLRFNKFIRNEGRHLTVIDIHTCLINENGVVRFDCFQKGPRSVTGSVEPYVFWNKIGRQRVLQMIEQNLEYH
Protein: Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (Q57XN0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Multifunctional fusion protein
- Proline dehydrogenase
Sequence:
MGMCTDRCVGVCKLNLALMHFVGMGEVCVWRRCGERGKKKERNIEDKRKGEGGVHLNCLFCLLMCNMFFTFCASSFVLFYLNQMLPPLGEAHICVKIYKLKYIYIYIRSYLYCFLFLCKCVWDGSICVSEVFYLALDFVLLFVQTYIKGQGGNYTHAHTQKKEKDNCHTKSVTIMKISFIGCGNMGECILGGLIQSKQYPPESIRVFNRTKATVDRLCERYGVGGAQSATDAAAYADVIVIGVKPKVVCELLASIQSSVTANKIIVSVAAAISIASMEKALGSEARKIVRTMPNLPTRVGAGVTSITSNAHVTASEKETIFQLFRTIGIVVEVLESQIPAVSSVAGASPAYVFMFMEAMADAAVHGGLPRAQAYELAAQAVLGSAIMLQKCDMSPAQLKDMVCSPGGVTIEAVRILEKGGMRSAVIEAMIACTDKSKELEKGLN
Protein: DNA-dependent metalloprotease WSS1 (EC 3.4.24.-) (DNA damage response protein WSS1) (SUMO-dependent isopeptidase WSS1) (Weak suppressor of SMT3 protein 1) (P38838)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Subcellular location: Nucleus {ECO:0000269|PubMed:18336552}. Note=Present in a single sharp spot near the nuclear membrane, distinct from the spindle pole bodies and nucleolus. In dividing cells, the spot is exclusively present in the mother cell.
Interaction partners:
- Tyrosyl-DNA phosphodiesterase 1
- Ubiquitin-like protein SMT3
- DNA topoisomerase 1
- ATP-dependent helicase SGS1
- Ubiquitin-like-specific protease 2
- Protein BIM1
- DNA damage-inducible protein 1
- Cell division control protein 48
- Ubiquitin-like-specific protease 1
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5
Sequence:
MKTEGIKSPSAKYHDMAGSQRIPHKNPHIQKVAVLQSKPNKEDALNLIKEIAHKVSYLMKENHFKVTNLVEFYPRDQRLLGMNVNHGSKIMLRLRCSTDEFQFLPMECIMGTMLHELTHNLFGPHDKKFYNKLDELIGRQWVIEQRGLYDTFLGNGQRLGGRANLRSNRYPMTGISTNTGIVRKRGKGVKLGSLHPEGISSIDRGNSPRELAAFAAERRYRDDRWCGETKNNKDQIISDNISSSLEVVILDDDDEVLPGDTLIEVIDLT
Protein: ISG12a protein (Q70LN3)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAFSGTGTLVASIVSKMTSSAAMVKAGGAVSGTILAGSKGLILLTQSALGSATSALGALKVGTILSGFSASTLAASPIGEEPALVGREKKSDFRFSFPAAGKAARRHRKEGQSKIYLKGFEFSRAKAVVAVLGGAMTVAAVPPALSAVGFTASGIAASSLAAKMMSLSAIANGGGVPAGGLVAILQSAGAAGLSVPSTVIVGSAGSAVVASVMNICESFYPFLMGSEVADMATEVADMAIEVADISTEEALPNLSNTEKD
Protein: Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5) (Q8TDT2)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Zinc finger protein GLIS3
Sequence:
MDTTMEADLGATGHRPRTELDDEDSYPQGGWDTVFLVALLLLGLPANGLMAWLAGSQARHGAGTRLALLLLSLALSDFLFLAAAAFQILEIRHGGHWPLGTAACRFYYFLWGVSYSSGLFLLAALSLDRCLLALCPHWYPGHRPVRLPLWVCAGVWVLATLFSVPWLVFPEAAVWWYDLVICLDFWDSEELSLRMLEVLGGFLPFLLLLVCHVLTQATACRTCHRQQQPAACRGFARVARTILSAYVVLRLPYQLAQLLYLAFLWDVYSGYLLWEALVYSDYLILLNSCLSPFLCLMASADLRTLLRSVLSSFAAALCEERPGSFTPTEPQTQLDSEGPTLPEPMAEAQSQMDPVAQPQVNPTLQPRSDPTAQPQLNPTAQPQSDPTAQPQLNLMAQPQSDSVAQPQADTNVQTPAPAASSVPSPCDEASPTPSSHPTPGALEDPATPPASEGESPSSTPPEAAPGAGPT
Protein: AT5g02020/T7H20_70 (E3 ubiquitin-protein ligase RLIM-like protein) (Q9LZM9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GDSL esterase/lipase At5g18430
Sequence:
MEGRKKKASSSSPCSSSSLTSELFGSRENPSSPSSSGILGSIFPPPSKVLGRESVRQETVTGGCWNEKTSKTGGNVDRNREQQENHGSGYQQDQRVQPCHLSSSIYYGGPDVYFQPQNSTSNSTNKKDGGEDDSGSASRGNWWQGSLYY
Protein: Acidic phospholipase A2 Omo-E6 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (P0DJJ7)
Organism: Ovophis monticola (Chinese mountain pitviper) (Trimeresurus monticola)
Function: Snake venom phospholipase A2 (PLA2) that inhibits the ADP- and collagen-induced human platelet aggregation (By similarity). Exhibits strong hydrolytic activities and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular location: Secreted.
Interaction partners:
Sequence:
DLMQFETLIMKIAGRSGVWIYGSYGCYCG
Protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) (Q99K90)
Organism: Mus musculus (Mouse)
Function: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (By similarity). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (By similarity). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Endosome membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Cytoplasm, cytosol {ECO:0000269|PubMed:12150997}. Nucleus {ECO:0000269|PubMed:12150997}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome. {ECO:0000250|UniProtKB:Q9NYJ8}.
Interaction partners:
- NF-kappa-B essential modulator
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
- Mitogen-activated protein kinase kinase kinase 7
- TNF receptor-associated factor 6
- Receptor-interacting serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1
- Toll-like receptor 3
- Glycogen synthase kinase-3 beta
- Myeloid differentiation primary response protein MyD88
Sequence:
MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLHGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTARQTQQHSGWVSQFNPMNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPNTDEMISRSQPKVYISANATAGDEQGMRNQPTLFISTNSGPSAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDAEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF
Protein: Zinc transporter 3 (ZRT/IRT-like protein 3) (OsZIP3) (Q7XLD4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Zinc transporter that may mediate zinc uptake from the rhizosphere. Seems specific to zinc ions and may not transport other divalent cations.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGAKKHTLQVLPWLLLFAQHTAASACDCANTTDGADRQGAMKLKLIAIASILAAGAAGVLVPVIGRSMAALRPDGDIFFAVKAFAAGVILATGMVHILPAAFDALTSPCLKRGGGDRNPFPFAGLVSMSAAVSTMVVDSLAAGYYHRSQFRKARPVDNINVHKHAGDERAEHAQHINAHTHGGHTHSHGDIVVCGSPEEGSVAESIRHKVVSQVLELGILVHSVIIGVSLGASVRPSTIRPLVGALSFHQFFEGVGLGGCIVQANFKVRATVIMAIFFSLTAPVGIVLGIAISSSYNVHSSTAFVVEGVFNSASAGILIYMSLVDLLATDFNNPKLQINTKLQLMAYLALFLGAGLMSMLAIWA
Protein: MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) (Q9NV56)
Organism: Homo sapiens (Human)
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Subcellular location: Nucleus.
Interaction partners:
- Transformation/transcription domain-associated protein
- Mortality factor 4-like protein 2
- DNA methyltransferase 1-associated protein 1
- Mortality factor 4-like protein 1
- YEATS domain-containing protein 4
- Histone acetyltransferase KAT5
- Chromatin modification-related protein MEAF6
- Enhancer of polycomb homolog 1
- Bromodomain-containing protein 8
- Inhibitor of growth protein 3
Sequence:
MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT
Protein: At1g71480 (Nuclear transport factor 2 (NTF2) family protein) (Q9C9I5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative RNA-binding protein family protein)
- Probable gamma-secretase subunit PEN-2
- Protein ASPARTIC PROTEASE IN GUARD CELL 2
- tRNA-splicing endonuclease subunit Sen2-1
- Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3A
- Starch synthase 3, chloroplastic/amyloplastic
- RNA-binding protein CP33, chloroplastic
- Nuclear transport factor 2
- Ferric reduction oxidase 6
- Cytochrome c-2
Sequence:
MSFTASLVSYLTSPSLVSLNHLPPSFFLPTKLVKPTSLTHSQPPRLSASYGPAAKAATANDVVPETAPTSASEVVSSFYAAVNVHDLSSVTDLIAQDCVYEDLVFSSPFVGRKAILDFFGKFIESTSTDLQFVIDDISTEDSSAVGVSWHLEWKGKNFPFSKGCSFYRLEVIDGKRQIVYGRDCVEPAIKPGETVLAAIKGVTWLLQKFPQLADQF
Protein: CaM kinase-like vesicle-associated protein (1G5) (Q63092)
Organism: Rattus norvegicus (Rat)
Function: Has no detectable kinase activity in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8283228}; Peripheral membrane protein {ECO:0000269|PubMed:8283228}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:8283228}; Peripheral membrane protein {ECO:0000269|PubMed:8283228}. Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures.
Interaction partners:
Sequence:
MPFGCVTLGDKKNYNQPSEVTDRYDLGQVVKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSGTAATSDAATPGAAGGAVAAAAGGAAPASGASATVGTGGDAGCAAKSDDMASADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTPATDRSATPATDGRATPATEESTVPAAQSSAAPAAKAAATPEPAVAQPDSTALEGATGQAPPSSKGEEATGCAQESQRVETS
Protein: ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3) (P59634)
Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV)
Function: Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex. Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities.
Subcellular location: Host endoplasmic reticulum membrane {ECO:0000269|PubMed:17108045, ECO:0000269|PubMed:17532020, ECO:0000269|PubMed:17596301}. Host Golgi apparatus membrane {ECO:0000269|PubMed:17108045, ECO:0000269|PubMed:17596301}. Host cytoplasm {ECO:0000269|PubMed:22820404}. Note=Localizes to virus-induced vesicular structures called double membrane vesicles. {ECO:0000269|PubMed:17108045, ECO:0000269|PubMed:17596301, ECO:0000269|PubMed:22026976}.
Interaction partners:
Sequence:
MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP
Protein: Forkhead box protein P1 (XlFoxP1) (Q5W1J5)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MMTPQVITPQQMQQILQQQVLTPQQLQVLLQQQQALMLQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQQQQVATQQLAFQQQLLQMQQLQQQHLLTLQRQGLLSIQPGQPTLPLQSLAQGMIPAELQQLWKEVTGSHTADDVVCNNHSTLDLSTTCVSSTAQPKTSLLLNSQASTNGQASVLTLKRESSSHEEYTHNHPLYGHGVCKWPGCETICEDFPSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLSKDKERLQAMMSHLHVKSTEPKASPQPLNLVSSATLSKTASEASPQSLPHTPTTPTAPLTPITQGPSVITTTSIHNVGPIRRRYSDKYNIPISSDFAQNQEFYKNAEVRPPFTYASLIRQGILESPEKQLTLNEIYNWFTRQFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEMEFQKRRPQKISGSPTLIKNIQTSHAYCSPLSAALQASMAENSLPLYTTASMGNPALNSLANAIREDLNGVMEHTSSNGSDSSPGRSPMQGMHQVHVKEEPLDHDDNDGPLSLVTTANHSPDFDRDRDYEDDPVNDDME
Protein: Threonine--tRNA ligase editing subunit (Ser-tRNA(Thr) hydrolase) (Threonyl-tRNA synthetase 2) (ThrRS 2) (Threonyl-tRNA synthetase editing subunit) (ThrS-ed) (Q9YFY3)
Organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Function: Freestanding tRNA editing subunit of threonine--tRNA ligase, the catalytic subunit is probably AC Q9YDW0. Deacylates (edits) mischarged L-seryl-tRNA(Thr) in trans; has no activity on correctly charged L-threonyl-tRNA(Thr). Probably does not aminoacylate tRNA(Thr) (By similarity). Deacylates correctly charged glycyl-tRNA(Gly), but not glycyl-tRNA(Gly)(2'-dA76) (the terminal 2'-OH of tRNA adenine 76 has been dehydroxylated) nor the 2'-fluoro tRNA derivative, strongly suggesting the editing function is catalyzed by the 2'-OH of A76 of tRNA(Thr).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Threonine--tRNA ligase catalytic subunit
- Tyrosine--tRNA ligase
- Glycine--tRNA ligase
- Probable translation initiation factor IF-2
- GMP synthase
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL22
Sequence:
MRLLYLHADRFEYKTVKPALKNPPDPPGEASFGEALVVFTTVEDGDGPQTVMYAASDIASHSSRLKVTTVILYPYAHLSSRLAKPMAAHKRLIELEGALRTKFPGHVHRAPFGWYKSFSIACKGHPLAELSRSFTEAGALQPWPAVEDYKTGLSGEVLARAGLLGGGSLSPASWALEVHRRLAEEVVGPAESVGFGESLSEAYQACISSSVTTLLMGPYPPSIVFGPLEDDPVEAVSRVLGLISPQLEGVKPLLSGGEGALKASSPDGAELPVAFLKEGRVCLGPTLSFFKLAVSMLVEKARKEGLTPYLNPTLTPVQSAVIPVDSESEGYAQRIAEDLAASGVRVSIVRGSGLGRRVREAGRSWASLVIVVGKREEETGTVVVRRRWEPGKQEVLTLDELSSEAKKLASGSRGSLYSTTL