wanglab/gogpt-training-data huggingface dataset:
Protein: KH domain-containing RNA-binding protein QKI (Protein quaking) (RqkI) (Q91XU1)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96PU8}. Cytoplasm {ECO:0000269|PubMed:11178867}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 13
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 4
- Mediator complex subunit 12
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 29
Sequence:
MVGEMETKENPNPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN
Protein: Glucan endo-1,3-beta-glucosidase 2 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase 2) ((1->3)-beta-glucanase 2) (Beta-1,3-endoglucanase 2) (Beta-1,3-glucanase 2) (Q9C7U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Non-structural maintenance of chromosomes element 1 homolog
- alpha-D-xyloside xylohydrolase
- Structural maintenance of chromosomes protein 5
- E3 SUMO-protein ligase MMS21
- Non-structural maintenance of chromosomes element 4 homolog B
- Non-structural maintenance of chromosomes element 4 homolog A
- Structural maintenance of chromosomes protein 6B
- Structural maintenance of chromosomes protein 6A
- Multicopper oxidase LPR1
Sequence:
MASLLHLLLLSLSLLVLASASPSPPADEGSYIGVNIGTDLSDMPHPTQVVALLKAQEIRHIRLYNADPGLLIALANTGIKVIISIPNDQLLGIGQSNSTAANWVKRNVIAHYPATMITAVSVGSEVLTSLSNAAPVLVSAIKNVHAALLSANLDKLIKVSTPLSTSLILDPFPPSQAFFNRSLNAVIVPLLSFLQSTNSYLMVNVYPYIDYMQSNGVIPLDYALFKPIPPNKEAVDANTLVRYSNAFDAMVDATYFAMAFLNFTNIPVLVTESGWPSKGETNEPDATLDNANTYNSNLIRHVLNKTGTPKRPGIAVSTYIYELYNEDTKAGLSEKNWGLFNANGEPVYVLRLTNSGSVLANDTTNQTYCTAREGADTKMLQAALDWACGPGKIDCSPIKQGETCYEPDNVVAHANYAFDTYYHQTGNNPDACNFNGVASITTTDPSHGTCVFAGSRGNGRNGTSVNITAPSANSTTSSGIRSDLYYSRGIWSILTVMILNVANIL
Protein: Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) (P0AC81)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the isomerization of the hemithioacetal formed spontaneously from methylglyoxal and glutathione, to S-lactoylglutathione, which is then hydrolyzed by a type II glyoxalase (GloB or GloC). Is involved in methylglyoxal (MG) detoxification (Probable). Involved in resistance to hypochlorous acid (HOCl), which is the active component of household bleach and a powerful antimicrobial during the innate immune response.
Interaction partners:
- Hydroxyacylglutathione hydrolase GloB
- Hydroxyacylglutathione hydrolase GloC
- Protein/nucleic acid deglycase 1
- N-ethylmaleimide reductase
- HTH-type transcriptional repressor NemR
- Lactaldehyde dehydrogenase
- Glyoxylate/hydroxypyruvate reductase B
- Glyoxylate/hydroxypyruvate reductase A
- Primary amine oxidase
- L-threonine dehydratase biosynthetic IlvA
Sequence:
MRLLHTMLRVGDLQRSIDFYTKVLGMKLLRTSENPEYKYSLAFVGYGPETEEAVIELTYNWGVDKYELGTAYGHIALSVDNAAEACEKIRQNGGNVTREAGPVKGGTTVIAFVEDPDGYKIELIEEKDAGRGLGN
Protein: At5g16260 (RNA binding (RRM/RBD/RNP motifs) family protein) (Q9LF02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nuclear protein-like
- At2g32600/T26B15.16
- DEAD-box ATP-dependent RNA helicase 42
- Splicing factor SF3a60 homolog
- Proline-rich spliceosome-associated
- DEAD-box ATP-dependent RNA helicase 45
- Pliceosome associated protein-like protein
- Small nuclear ribonucleoprotein Sm D2
- Spliceosome-associated protein 130 B
- U2 small nuclear ribonucleoprotein A'
Sequence:
MSDSDNLQLPPSSTGATVAATDVGWYILGENQQNLGPYTFSELCNHFRNGYLLETTLVWADGRSEWQPLSAIPDLMSRISGAEIAYPAVGSSGLINGSNAGTRQEKQDYTASASTEDEFEKWQREIKDAEAEAERLKNGSVSGTELVEDDHERASSPPEGEDEFTDDDGTKYKWDRARRVWVPQDDPPLGSVDPYGLEEMTFAKEDEVFPTINILDTSVDKKDASKDDVAGKKEEDGSDETAEINSNGKRKLPEPETEKKEPNKPPDSWFELKVNPHIYVNGLPDDVTIEEVAEVFSKCGIIKEDDTGKPRIKLYSDKATGKLKGDALISYMKEPSVDLAIKILDGAPLRPADKLLMSVSRAKFEQKGERFITKQTDNKKKKKLKKVEQKLLGWGGTDDSKVSIPATVVLRYMFSPAELMADEDLVAELEEDVKEESLKHGPFDSVKVCEHHPQGVVLVRFKDRRDAQKCIEAMNGRWYAKRQIHASLDDGSVNHATVRDFDLEAERLDQFAAELEAAE
Protein: PRA1 family protein E (AtPRA1.E) (Prenylated Rab acceptor 4) (Q9FRR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
Interaction partners:
- PRA1 family protein A3
- PRA1 family protein H
- PRA1 family protein A2
- PRA1 family protein A1
- Aspartic proteinase A1
Sequence:
MNQKPPPYGYGGAGGGGVGPSSTSNTTIIGTLSARAKQTTQSMITTLRPWREILDLSALSLPRGYDEAMAHLKHNISYFRGNYALAVLAIVFLGLIYHPMSMIAFIVVFIGWILLYFSRDANDSIVISGKEVDDKIVLVLLSLVTVLALVYTDVGENVLVSLIIGLLIVGAHGAFRNTDDLFLDEESARRGGLVSAGSGNRPPSSYTPI
Protein: T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) (P06729)
Organism: Homo sapiens (Human)
Function: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:2437578}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Lymphocyte function-associated antigen 3
- CD48 antigen
- T-cell surface glycoprotein CD8 alpha chain
- T-cell surface glycoprotein CD4
- T-cell surface glycoprotein CD5
- Intercellular adhesion molecule 1
- CD2 antigen cytoplasmic tail-binding protein 2
- CD2-associated protein
- Tyrosine-protein kinase Lck
- T-cell-specific surface glycoprotein CD28
Sequence:
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
Protein: CooA protein (P72322)
Organism: Rhodospirillum rubrum
Interaction partners:
Sequence:
MPPRFNIANVLLSPDGETFFRGFRSKIHAKGSLVCTGEGDENGVFVVVDGRLRVYLVGEEREISLFYLTSGDMFCMHSGCLVEATERTEVRFADIRTFEQKLQTCPSMAWGLIAILGRALTSCMRTIEDLMFHDIKQRIAGFFIDHANTTGRQTQGGVIVSVDFTVEEIANLIGSSRQTTSTALNSLIKEGYISRQGRGHYTIPNLVRLKAAADGDRDDDDD
Protein: Laccase-12 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 12) (Diphenol oxidase 12) (Urishiol oxidase 12) (Q9FLB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lignin degradation and detoxification of lignin-derived products.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Phenylalanine ammonia-lyase 1
- Phenylalanine ammonia-lyase 4
- Phenylalanine ammonia-lyase 3
- Phenylalanine ammonia-lyase 2
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- Basic blue protein
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Probable caffeoyl-CoA O-methyltransferase At4g26220
- Trans-cinnamate 4-monooxygenase
Sequence:
MTTVHTFSILLFFCSLFSASLIIAKVQHHDFVIQETPVKRLCKTRNAITVNGMFPGPTLEVNNGDTLEVKVHNRARYNITIHWHGVRQIRTGWADGPEFVTQCPIRPGKSYTYRFTIQGQEGTLWWHAHSSWLRATVYGALIIHPTPGSSFPFPKPDRQTALMLGEWWNANPVDVINQATRTGAAPNISDAYTINGQPGDLYNCSTKETVVVPINSGETSLLRVINAALNQPLFFTVANHKLTVVGADASYLKPFTTKVLMLGPGQTTDVLLTADQPPKRYYIAARAYQSAQNAPFDNTTTTAILQYKKTTTTSKPIMPVLPAFNDTNTVTSFSRKFKSLRNVVVPKTIDDNLFFTIGLGLDNCPKKFPKSRCQGLNGTRFTASMNNVSFVLPSNFSLLQAHSNGIPGVFTTDFPSKPPVKFDYTGNNISRALFQPVKGTKLYKLKYGSRVQVVLQDTNIVTSENHPIHLHGYDFYIVGEGFGNFNPKKDTSKFNLVDPPLRNTVAVPVNGWAVIRFVADNPGVWLMHCHLDVHIKWGLAMAFLVDNGVGELETLEAPPHDLPIC
Protein: Growth arrest-specific protein 1 (GAS-1) (P54826)
Organism: Homo sapiens (Human)
Function: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Sonic hedgehog protein
- Protein patched homolog 1
- Cell adhesion molecule-related/down-regulated by oncogenes
- Brother of CDO
- Desert hedgehog protein
- Indian hedgehog protein
- Protein patched homolog 2
- Low-density lipoprotein receptor-related protein 2
- Growth arrest-specific protein 2
- Protein smoothened
Sequence:
MVAALLGGGGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPECSYAYNQYAEACAPVLAQHGGGDAPGAAAAAFPASAASFSSRWRCPSHCISALIQLNHTRRGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGAGGVMGCTEARRRCDRDSRCNLALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAALLNDCVCDGLERPICESVKENMARLCFGAELGNGPGSSGSDGGLDDYYDEDYDDEQRTGGAGGEQPLDDDDGVPHPPRPGSGAAASGGRGDLPYGPGRRSSGGGGRLAPRGAWTPLASILLLLLGPLF
Protein: Chaperone protein DNAJ, putative (Q57U00)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSADPKTDVPHGFRLIPMLFYEYFAGSAFNVDVLKAIFRSIGTAGSNCGKGLGLFSRTVNIVIAQLSQRVVEWCVVAYFTSSNSLLLHRAAVLHCTFPYVQHYRFTNCWITHFPCSVAKIFVPSFLWNWVRNTIVGLPSLGDDGTDGVNDYGESISFYNSSYASSTPTAVVASSLVSEITEHIIQQIAWAVLFYRSRDEKDALWPMVKRYLSTTVESLTHSVLIVCARSVGAWFGGRVSRNPSSGCIFWCERTLLLLLGPAIGKSGRRLGVKLLQELERFHPTTEAEARADDARSNAESSAHDGEDDWNTGSFFYPTTLSTVDYYEVLGVERTASLEDIKRAYRAAALQNHPDHAPKEAEAQNAAQERMAVINQAYETLGTDSKRRKYDQACANIQIPGVFSRFNDFPLSTHDGSTVLVAVASLVVKSFVAYAQYYSSFLELTGLGKGPLRYVGFL
Protein: Acyl-CoA synthetase X2 (EC 6.2.1.3) (Q9VDU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MLDLNGNPATSYDPVQKVWSGCSRHSLYNEELTVGQIIFRQLQRQPQRIFQISHTDNTRLTRFQMLQNAAKIGCYLRDQGFKKETDLVGLMARNSTHVGALAYGCLFNGTPFHAVNPNLEHNTISSLYKITRPRILCCDTADYEKIKDIGASLGALIITVNGKLPGVISVADILQNPLPDDYEPAQFQRGVDRTMAILCSSGTTGTPKAVTLSNSRKLFEMHSYLGSDDVQYAPSTLDWLTGLITLVTAAVFGTVRLISSEMFSTAHFLDICEQHEVSWTIMANSHVAMLANCPKTSAQKLRSLKHLLFAGGHCLVATLKKMQSFLHGSGILRNAYGLTEVGTLVSYNYDTQSKPTSVGRLMANIRVKIVDSSGQLQGPKGLGEILCHNGQPWSGYVGNPLATAEMRDSAGWYHTGDVGYFDEDHYLHIVERKKDMLKYLGMMYYPHEVEEVIAQMPDVAEVCVFGIFRETEGDAAAASVVLRSGSKLDPKHVEQYVRKNVSVQFKHLHGGVQFVPQLAKSANGKVNRQAVKAAYLRDATQS
Protein: Interferon, alpha-inducible protein 27 (E9Q1C5)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAFSGTGTLVASIVSKMTSSAAMVKAGGAVSGTILAGSKGLILLTQSALGSATSALGALKVGTILSGFSASTLAASPIGEEPALVGREKKSDFRFSFPAAGKAARRQRKEGQSKIYLKGFEFSRAMTVAAVPPALSAVGFTASGIAASSLAAKMMSLSAIANGGGVPAGGLVAILQSAGAAGLSVPSTVIVGSAGSAVVASVMNICESFYPFLMGSEVADMATEVADMAIEVADISTEEALPNLSNTEKD
Protein: Uncharacterized urease accessory protein ureG-like (Q96WV0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably facilitates nickel incorporation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized urease accessory protein UreF-like
- Urease
- Uncharacterized urease accessory protein ureD-like
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL28m
Sequence:
MAIPFLHKGGSDDSTHHHTHDYDHHNHDHHGHDHHSHDSSSNSSSEAARLQFIQEHGHSHDAMETPGSYLKRELPQFNHRDFSRRAFTIGVGGPVGSGKTALLLQLCRLLGEKYSIGVVTNDIFTREDQEFLIRNKALPEERIRAIETGGCPHAAIREDVSGNLVALEELQSEFNTELLLVESGGDNLAANYSRDLADFIIYVIDVSGGDKIPRKGGPGITESDLLIINKTDLAKLVGADLSVMDRDAKKIRENGPIVFAQVKNQVGMDEITELILGAAKSAGALK
Protein: Repressor of RNA polymerase III transcription MAF1 (E9PSH4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037240}.
Interaction partners:
Sequence:
MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMFKQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEEEGPLSDKCSRKTLFYLIATLNESFRPDYDFSTARSHEFSREPSLSWVVNAVNCSLFSAVREDFKDLKPQLWNAVDEEICLAECDIYRWAGIPADGLQASRFVGHLAPHTTCHPILPSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGNELDMELGEEEVEEESRSGGSGAEETSTMEEDRVPVICI
Protein: Transcription repressor OFP4 (Ovate family protein 4) (AtOFP4) (F4HNU8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors. Forms a transcription repression complex with KNAT7 which regulates secondary cell wall formation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Homeobox protein knotted-1-like 7
- Homeobox protein knotted-1-like 3
- BEL1-like homeodomain protein 6
- BEL1-like homeodomain protein 1
- Transcription repressor OFP15
- Transcription repressor OFP16
- Transcription repressor OFP18
- Transcription repressor OFP13
- BEL1-like homeodomain protein 10
- Transcription repressor OFP11
Sequence:
MRNYKLRLSVMSPSEWFHKLKNMTKPRKKHSLPLYSINTTKKRKPSSESKSLPYSSTSYFFNRSRSRTSFESRILQISPRNSLHNIQSKRKTVYKPSPPSSSIVSAGFNKTFHQSHDSLSASSNLKVISSEDDIIIDMNNRDFKKKTFKEITKFDSTEKACRASNRTKETHIPHHLSVKVSKEKEDEEEDACRTKKKHQKTLVSSGRRSSAKSPRIKLRARSPRIQVSPRRSKSRSQNKQILDSFAVIKSSIDPSKDFRESMVEMIAENNIRTSNDMEDLLVCYLTLNPKEYHDLIIKVFVQVWLEVINSTFASK
Protein: Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3) (Q9HAB3)
Organism: Homo sapiens (Human)
Function: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4-hydroxybutyrate (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17197387, ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:24253200, ECO:0000269|PubMed:27702554}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Free fatty acid receptor 2
Sequence:
MAAPTPARPVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYVSVLVALGNLGLLVVTLWRRLAPGKDEQVPIRVVQVLGMVGTALLASLWHHVAPVAGQLHSVAFLALAFVLALACCASNVTFLPFLSHLPPRFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPINGTPGPPLDFLERFPASTFFWALTALLVASAAAFQGLLLLLPPPPSVPTGELGSGLQVGAPGAEEEVEESSPLQEPPSQAAGTTPGPDPKAYQLLSARSACLLGLLAATNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLGGLSLLGVFCGGYLMALAVLSPCPPLVGTSAGVVLVVLSWVLCLGVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYHVFHSRKDCADPCDS
Protein: DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) (Q29455)
Organism: Bos taurus (Bovine)
Function: Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18596047}. Membrane {ECO:0000269|PubMed:18596047}; Lipid-anchor {ECO:0000269|PubMed:18596047}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:8702643}. Melanosome {ECO:0000250|UniProtKB:Q9H3Z4}. Cell membrane {ECO:0000250|UniProtKB:Q9H3Z4}. Note=The association with membranes is regulated by palmitoylation. {ECO:0000269|PubMed:18596047}.
Interaction partners:
- Heat shock cognate 71 kDa protein
- Vesicle-associated membrane protein 2
- Ras-related protein Rab-3A
- Synaptotagmin-1
- Tuftelin-interacting protein 11
- Cell division cycle 5-like protein
- Vesicular inhibitory amino acid transporter
- Crooked neck-like protein 1
- Pleiotropic regulator 1
- Pre-mRNA-processing factor 19
Sequence:
MADQRQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHPDKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFIFCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQSDEREAADTPIVIQPASATETTQLTADSHPSYHTDGFN
Protein: Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) (Q586C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365051}.
Interaction partners:
- U2 small nuclear ribonucleoprotein B, putative
- PRP1 splicing factor N-terminal domain-containing protein
- PRP8 protein homologue
- Sm protein F
- Small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein, putative
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- U5 small nuclear ribonucleoprotein component, putative
- Sm protein B
- Sm protein G
Sequence:
MSGEEPTKLQRTESGARVIKTKEFLRTSVAEGPFCLLDSAVKNGTRVFIQSRYNKSLVATVVAFDKHFNLVLRDAVELTMVNNEQKERSIRNMFLRGASVVFIVRLPQSTV
Protein: Erythrocyte membrane protein band 4.1-like 3 (A0A8I5Y1G9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MTTESGSDSESKPDQEAEPQEAAGPQEQAGAQAAPEPAGGNVEEQPGLEQFPEAAAHSTPVKREVSDKDRDFAAAAAKQLEYQQFEDDKLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGNDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDRRKKAEEATPVAALRHEGKTDSERTDTAADGETSATENSLIKRIKGENVYVKHSNLMLEELDKTQDELVKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTETIETEVEPTPHPQPLSTEKVLQETVLVEERHVMNVHASGDASHTARDDVDATESAPADRHSGNGKEGSSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVESISVGSVSPGGVKLETSTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED
Protein: V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) (Q9H7M9)
Organism: Homo sapiens (Human)
Function: Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Immunoglobulin superfamily member 11
- Immunoglobulin heavy variable 3-43D
- B- and T-lymphocyte attenuator
- Galectin-9
- Transmembrane and immunoglobulin domain-containing protein 2
- Lymphocyte activation gene 3 protein
- Hepatitis A virus cellular receptor 2
Sequence:
MGVPTALEAGSWRWGSLLFALFLAASLGPVAAFKVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHGGHQAANTSHDLAQRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRVHGAMELQVQTGKDAPSNCVVYPSSSQDSENITAAALATGACIVGILCLPLILLLVYKQRQAASNRRAQELVRMDSNIQGIENPGFEASPPAQGIPEAKVRHPLSYVAQRQPSESGRHLLSEPSTPLSPPGPGDVFFPSLDPVPDSPNFEVI
Protein: Protein disulfide-isomerase LQY1, chloroplastic (EC 5.3.4.1) (Protein LOW QUANTUM YIELD OF PHOTOSYSTEM II 1) (Q8GSJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein disulfide-isomerase probably involved upon formation of a complex with HHL1 in maintaining photosystem II (PSII) activity under high light by regulating repair and reassembly of PSII complexes.
Subcellular location: Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=More abundant in stroma-exposed thylakoids.
Interaction partners:
- Protein HHL1, chloroplastic
- Protein PHOTOSYSTEM I ASSEMBLY 2, chloroplastic
- Protein disulfide-isomerase SCO2
- DnaJ/Hsp40 cysteine-rich domain superfamily protein
- PsbP-like protein 1, chloroplastic
- Thiol-disulfide oxidoreductase LTO1
- Defensin-like protein 178
- Defensin-like protein 176
- Protein HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 244
- Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic
Sequence:
MPVSAPSPPRLHSPFIHCPINFTPSSFSARNLRSPSTSYPRIKAELDPNTVVAISVGVASVALGIGIPVFYETQIDNAAKRENTQPCFPCNGTGAQKCRLCVGSGNVTVELGGGEKEVSNCINCDGAGSLTCTTCQGSGVQPRYLDRREFKDDD
Protein: Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) (Q9JK30)
Organism: Mus musculus (Mouse)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UBD5}. Chromosome {ECO:0000250|UniProtKB:Q9UBD5}.
Interaction partners:
- Origin recognition complex subunit 5
- Origin recognition complex subunit 4
- Cell division control protein 6 homolog
- Origin recognition complex subunit 2
- DNA replication factor Cdt1
- Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM5
Sequence:
MHTGPRTMATSSVSKGCFVFKPDFKKRKVFVPIEDYFNNEELDSEDSKLRFETYSLLWQRMKSETEQLQEELNENLFDNLVDFLQKSHPEFQKNSRDWGSQMKFREIPTAALILGVNVTDHDVILRSLTETLQNNVTPYVVSLQAKDCPDVKHFLQKFTSQLMDCCVDRHSKEVTSGKALKKTNYSMDSLCSWYSAVTQKADHKVTIKKRTASGHWRSPPVVLILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLLLTPQFPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVLCCDLSEAKKRVNVFSVSQCENIRRLPSFRRYVENQPLGKQVALLTNETFLKEKTQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQIRELYCTCLEKKIWDSEEYKSALQLLRMLAKDELVSILQRCIEVLDSSTEKQLGNTTQKIKDFLTQFQNLDADSKEEEDACGSQPKGLQKTDLYHLQKSLLEMKELRRTKKPTKFEMLRENVMNFIDNLVRDYLLPPESQPLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNEELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAFATVVTAAEKMDANSTVSEEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
Protein: Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) (Q9EPR2)
Organism: Mus musculus (Mouse)
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine (By similarity).
Subcellular location: Secreted. Cytoplasm {ECO:0000250}.
Interaction partners:
- Group 10 secretory phospholipase A2
- Group 3 secretory phospholipase A2
- Group IID secretory phospholipase A2
- Group IIC secretory phospholipase A2
- Group IIF secretory phospholipase A2
- Group IIE secretory phospholipase A2
- Phospholipase A2
- Phospholipase A2 group V
- Cytochrome P450 2E1
- Phospholipase A and acyltransferase 3
Sequence:
MVTPRPAPARSPALLLLLLLATARGQEQDQTTDWRATLKTIRNGIHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPVPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLSQNVQACETTVELLFDSVIHLGCKPYLDSQRAACWCRYEEKTDL