wanglab/gogpt-training-data huggingface dataset:
Protein: DNA polymerase sliding clamp (Proliferating cell nuclear antigen homolog) (PCNA) (Q9UYX8)
Organism: Pyrococcus abyssi (strain GE5 / Orsay)
Function: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.
Interaction partners:
- Flap endonuclease 1
- DNA ligase
- DNA polymerase 1
- DNA polymerase II small subunit
- DNA primase large subunit PriL
- DNA primase small subunit PriS
- Replication factor C small subunit
- DNA polymerase II large subunit
- DNA helicase
- RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination
Sequence:
MPFEIVFEGAKEFAQLIETASRLIDEAAFKVTEEGISMRAMDPSRVVLIDLNLPASIFSKYEVDGEETIGVNMDHLKKVLKRGKAKETLILRKGEENFLEISLQGTATRTFKLPLIDVEEIEVDLPELPFTAKVVILGDVIKEAVKDASLVSDSMKFIAKENEFTMRAEGETQEVEVKLTLEDEGLLDIEVQEETKSAYGISYLSDMVKGLGKADEVTIKFGNEMPMQMEYYIRDEGRLIFLLAPRVEE
Protein: Chromatin modification-related protein EAF1 (ESA1-associated factor 1) (Vacuolar import and degradation protein 21) (Q06337)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Actin-related protein 4
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein YNG2
- Chromatin modification-related protein EAF5
- Chromatin modification-related protein EAF6
- Histone acetyltransferase ESA1
- SWR1-complex protein 4
- Actin
- Protein AF-9 homolog
Sequence:
MSSRPSSAVPNSASLSEDQSSDRSKFPKADDLIDERDRKLTELYCVSRLNQLLELTDENKLRKEIDAFLKKNDIRRGIRFDEASLPKLLHTAATPITKKKLKDVNLINVPNQRLSDSKMSRELPENSENVSVKSESHFVPSHDNSIRENMMDSLRPAEKTGGMWNKRPLESTMGGEEERHEKRQKMQSQSLESSNNSEMASLPISPRPPVPNALAHYTYYENIEYPPADPTEVQPAVKFKDPLIKNIMAKEIDTSDHYNENNVDALETVFLLMNDYIPSKIPQALPLAELKYMSQTLPLINLIPRAHKALTTNIINNALNEARITVVGSRIEELRRLGLWSLRQPKRFIDPWKQHNTHQNILLEEAKWMQADFKEGHKYKVAICTAMAQAIKDYWTYGEICCVKRKTLLPGKENKLSDDGRISEKSGRPSDTSRNDSDISIAGKDDIGIIANVDDITEKESAAANDNDENGKNEAGAKSDFDFADGLLSQEGAHDQIISSIDTKLLLKKPSSSSEVVLIQHEVAASSALIETEESKKELAPPFKLSIFVDELNTFEKTLIQDLPLYNGINEERPKKDDSLPFIPISKSVVSLDDNGFYKLLERQLIDEEPSISQLSKRRGMFYGNRRNHYLRPPAVPSLRYLQNRTPTIWLSEDDQELVKNINTYGYNWELISAHMTHRLTYSYLSNIERRTPWQCFERFVQLNERFNFSDLKGPRAHSAQQWLIEAHKFQQRQNRRISPLGVNTESIQRGHRRLRWASMFEAIRKCMKKRENTPRPNPTQPRKPLDCKNMKVPTPAEMSLLKAQRDEALRRDIQLRRTVKNRLQQRQQQSQQAHSSRAQSPIPSNGKSSSNLARNGQASAPRPNQKQYTEQDIIESYSRKLLEQKPDIGPEMALKAAKNYYRTLREQQQQLKQHQIQQQRQQLQEESSHVQQLQQLQPGSQAPPPKSSPSQSSLSNISNINSAPRIKSPTPQEILQRFQKQ
Protein: Putative glutaredoxin-C12 (AtGrxC12) (Protein ROXY 5) (O82254)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Acid phosphatase-like protein
- At2g16660/T24I21.7
- Protein NRT1/ PTR FAMILY 4.7
- Delta-9 acyl-lipid desaturase 1
- UPF0603 protein At1g54780, chloroplastic
- Kunitz trypsin inhibitor 1
- Defensin-like protein 196
Sequence:
MERVRDLASEKAAVIFTKSSCCMCHSIKTLFYELGASPAIHELDKDPQGPDMERALFRVFGSNPAVPAVFVGGRYVGSAKDVISFHVDGSLKQMLKASNAIWL
Protein: RNA polymerase-binding transcription factor CarD (P9WJG3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- RNA polymerase-binding protein RbpA
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- RNA polymerase sigma factor SigA
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- Probable transcriptional regulator WhiB7
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- Putative L-lactate dehydrogenase
Sequence:
MIFKVGDTVVYPHHGAALVEAIETRTIKGEQKEYLVLKVAQGDLTVRVPAENAEYVGVRDVVGQEGLDKVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDQERGLSAGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAAAS
Protein: Period circadian regulator 1 (J3QLQ5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGPLEGADGGGDPRPGESFCPGGVPSPGPPQHRPCPGPSLADDTDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQSPSPPSSSIAYSLLSA
Protein: Contactin rig-6 (H2KZ60)
Organism: Caenorhabditis elegans
Function: Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:23123963, ECO:0000269|PubMed:28901288}. Cell projection, axon {ECO:0000269|PubMed:23123963, ECO:0000269|PubMed:28901288}. Synapse {ECO:0000269|PubMed:23123963}. Cytoplasm {ECO:0000269|PubMed:28901288}.
Interaction partners:
- Amyloid-beta-like protein
- Neuroglian
- NeuRonal IGCAM
- Immunoglobulin domain-containing protein Y54G2A.25
- Ig-like domain-containing protein
- Neuronal immunoglobulin domain-containing protein rig-3
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- InTestinal NeureXin-like
- EGF-like domain-containing protein C02B10.3
Sequence:
MMMLIRCISIFLLFGFVNALIDEASCPIGWQIASDQCVRIVIAPANLKHSKKYCHHEGGELMDTSVTLLLEDVMDLLKNLHENGLSEPTFHVGGMGQALNRTEDGNYKIITINPSSHFPFICSLNKMARRSLLFQQKLLPVGAPQISLTGQSEIYFHPRHDADYIALPCTVQGNPKPTVAWYKNDVEVLSPSMSNVSYLLSGGNLLVPASSTLAYSSFHCTARNSLGEVRSPPILLKPSFIDPFRPHRLDVYSLATGGAKLDCDAPAHQPKSLTYSWLYGSSTDRILSQNERKFISLDGTLFFSYVTAEDEDSYACSLSVYSTQSGHYGPFFRLISSTPKLVNSTFPPKLDSTQPQIFPEDPKVGDSIYLECFAYASPLPQYKWSRVDGKPIPARSHISNYGRVLKIEKVNYGDAGKYKCVAMNAFGSAAGEVHVKLRAPPSILQGLHDRLVPTESNVSFECLLSNADSYSSVEWFKDAKPIVPLLLPAEKRKRLKIDHNVLHLKFADETDSGVYQCVASNDVGSSSSSALLTVKDSAPVFPPNAMSRKVFAAFGSTVSIPCIFEASPRFHGKWADAGGSKLPQKGRIRDEEGVISIEKVLHEDAGLFFCTAHNKLGKAHAQVQLIVVNKPSIKTNFLDEETVNMSCEVELTCENSAECPEALFEWKINDRPAKEYPSLKSKVHEKKSGHKGRHLKQKVDLEVPKSLAGSRQIGRFACSSLYGGSSEFVTKPQLPSPIALTVEQMDEDGKKKKMFRLRWRLPPQHRDTRDHSPKVEGYLVELRTRKNRKWRAAERQLVGNMEKDSITVENLLPNTEYQFRVRSVESAAIGEPSIPSDWVKTAPGAPSETIDNLKWRSLDSQTLLVEWQPIEIGQESSGDNLRYRVSWSEATVGKNATDDMKLSNQDDDFENHLDSDQPQAILKLNTTEGCRMVVLAVRPVNDQGNGSVGTDTIAFLNSHGELKKVSLHNVKPINASHVNISWTWDNTSDCDTKHAVQITCINLSGSEISATVASDRIFWMLGGLEAETAYDCDLKAIDNHGSFGPASKKFRIHTKQHPPSETPLIGKLMMKQMKDTYTTILEWSSIELQKPNRTENGCGYKIFIYISETATEAIELDMPLQRLSDRRNPSARLDGLKLMYMYTIKVAGYNPGGIGPISEPRSIRLGSPGTMDYTTGSSDVPIPSLLLLLLLLLWRL
Protein: Normal mucosa of esophagus-specific gene 1 protein (Protein FOAP-11) (Q9C002)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:12209954}.
Interaction partners:
- Cytochrome c oxidase subunit NDUFA4
- Calcium-activated chloride channel regulator 1
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
Sequence:
MSFFQLLMKRKELIPLVVFMTVAAGGASSFAVYSLWKTDVILDRKKNPEPWETVDPTVPQKLITINQQWKPIEELQNVQRVTK
Protein: Cyclin-B2-4 (G2/mitotic-specific cyclin-B2-4) (CycB2;4) (Q9SFW6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-dependent kinase A-1
- Cyclin-dependent protein kinase inhibitor SMR11
- Cyclin-dependent kinases regulatory subunit 1
- Cyclin-dependent protein kinase inhibitor SMR2
- Mitotic spindle checkpoint protein BUBR1
- Cyclin-dependent kinase B2-2
Sequence:
MGGSDENRHGVIGPMNRQQGGLRGGKVIPTNGQTRRALSNINKNIIGAPVYPCAVKRPFTEKNGICNKKIPPVPVHRPVTRKFAAQLAENNLQIHKEETKKPDLISNEALDRIITDVEEGDFNEPMFVQHTEAMLEEIDKMEGIEMQDSNDIDAEVEESVMDIDSCDKNNPLSVVEYINDIYCFYKKNECRSCVPPNYMENQHDINERMRGILFDWLIEVHYKFELMEETLYLTINLIDRFLAVHQHIARKKLQLVGVTAMLLACKYEEVSVPVVDDLILISDKAYTRTEILDMEKLMANTLQFNFCLPTPYVFMRRFLKAAQSDKKLELLSFFMIELCLVEYEMLQYTPSQLAASAIYTAQSTLKGYEDWSKTSEFHSGYTEEALLECSRKMVGLHHKAGTGKLTGVHRKYNTSKFGYAARIEPAGFLLL
Protein: Probable transposase (O53337)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
Sequence:
MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSRELRRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARHLRRKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGRRRPRFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHLPTHDAYCLRIAITETMSDLPVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPWQRASNENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALLTSPDHQLLRR
Protein: Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (P2Y-like receptor) (R12) (Q13304)
Organism: Homo sapiens (Human)
Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- P2Y purinoceptor 12
- Integrin alpha-4
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
Protein: Small ribosomal subunit protein eS6A (40S ribosomal protein S6-A) (SP-S6) (P05752)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS7
- Elongation factor 3
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS27
- mRNA export factor elf1
- Large ribosomal subunit protein uL5A
Sequence:
MKLNISYPANGTQKLIEIDDDRRLRVFMEKRMGQEVPGDSVGPEFAGYVFKITGGNDKQGFPMFQGVLLPHRVRLLLRAGHPCYRPRRDGERKRKSVRGCIVGQDLAVLALAIIKQGEQDIPGLTDVTVPKRLGPKRASKIRRFFNLSKEDDVRQFVIRREVVPKKEGKKPYTKAPKIQRLVTPRTLQHKRHRFALKRRQAEKNREEAAEFAQLMAKRVAEAKQKREVVKARRASSLKK
Protein: phosphopyruvate hydratase (EC 4.2.1.11) (Q5EFD8)
Organism: Trichomonas vaginalis
Interaction partners:
- phosphoglycerate mutase
- Phosphoglycerate mutase
- Phosphoglycerate mutase
- Glucose-6-phosphate isomerase
- Glucose-6-phosphate isomerase
- Triosephosphate isomerase
- Triosephosphate isomerase
- MYCBP-associated protein
- Phosphoglycerate kinase
- Phosphoglycerate kinase
Sequence:
MNAEHDAIVKECIAEAAKAEDPIGTLSVLLKKKAPKAVIEKVVGREVLDSRGNPTVEVDVYVKYLGRVTLAARSSAPSGASTGVGEALELRDGDKARYGGKGTQQAAKNVTEKLSPALKGMCFCDFPALDKKICDTDGTVLKKNIGGNACTATSFALAEAGAAVQEIELFQYLAKAFYGGCDKVPKKFKLPSPFFNILNGGKHAGGNLKFQEFMVTPTRKVPFPDQLRMVAEVYQKLGGLLVKKYGLSAKNLGDEGGFAPNLNDPEEALTVIEEAIKAAGYEAGKDIMIGMDVASSEFYDEEKKLYEVEVGKFLNADQMIDYFDELLKKHPAIVSIEDALAELDYENWTKLNARLGQRVQLVGDDLYTTNPITIKKGLEGKWCNALLLKVNQIGTISEGMEAARLILNAGHRVMVSHRSGETCNSVIADLAVAIGAQSIKTGSTARGERIQKYTRLLQIYDYLKEHDMLAEE
Protein: Legumain (EC 3.4.22.34) (Protease, cysteine 1) (F1SD70)
Organism: Sus scrofa (Pig)
Interaction partners:
- Cystatin E/M
- Cathepsin B
- Cathepsin S
- Procathepsin L
- Cathepsin L
Sequence:
MIWEVAALLSLVLGIGAVPVDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIVHRNGIPDEQIIVMMYDDIANSEEGSRYCNPTPGIVINRPNGSDVYKGVLKDYTGEDVTPQNFLAVLRGDAEAVKGKGSGKVLKSGPRDHVFVYFTDHGATGILVFPNEDLHVKDLNETIHYMYKHRMYQKMVFYIEACESGSMMNHLPPNIDVYATTAANPRESSYACYYDEARATYLGDWYSVNWMEDSDSEDLTRETLHKQYQLVKSHTNTSHVMQYGNKSISAMKLVQFQGLKHKASSPISLPPVQHLDLTPSPEVPLTIMKRKLTRTNDLQESRRLVAEIDRHLQARNVIEKSVRKIVSLTVGSDAEVDRLLSQRDPLTAHECYQEAVLHFRTHCFNWHSPTYEYALRHLYVLANLCENSYPIASIKLSMDKVCLGYY
Protein: Uncharacterized protein (Q38BP5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKLLKFVNCDAPNVSPEALHFSMSRQRVSLHSGDTSDRRSGSRSSATEGNASIGKTWRIAEGGTPITGGYWLLGDNNEPIGPVQEVILAVPEVKEADVTPRGINESVVKNVEFFSKFGRSMQRTRETFGDTYLSAPKSVIPLSDAERTFAKRAERARMPLKRRAEAVDAEGGPGGEVVAAAATATAAAANPTACVEPSPRPVKKEKKSKKITTPTLTPVRSIKKET
Protein: Repulsive guidance molecule B homolog drag-1 (DRAGON homolog) (G5EDE5)
Organism: Caenorhabditis elegans
Function: Probably in association with the cell surface receptor unc-40, positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20534671}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}.
Interaction partners:
- Serine/threonine-protein kinase receptor sma-6
- Netrin receptor unc-40
- Protein dbl-1
- Leucine-rich repeats and immunoglobulin-like domains protein sma-10
- Cysteine-rich motor neuron 1 protein-like
Sequence:
MSIVYLVSITFIFSVFKPITSCRVEECAAWFQKTKDYENLVPKATERYCQVLQTYLKCMNDTQRYCHGNLRFHSSELIMRRHWKEFECEKWESCNDNSHVKRKHVNTCYFNPPPSNRKLKYCSLFGDPHLIMFNGSVQTCSEEGARPLVDNRYFLVQVTNRNVRGEALTTTVTKVTVLVRKHNCTASLRYEASSDEEGLPRGFVDGTTFQMTSKHSVEVLWQDDNYVEIALHFIHSSIHIRRQGPYLSVSVRAPTIVLETGGDVARELCWSGCRKSSRIPAELAVEMTKKFAECYRRRVHVPKKVAEDRCKDIGNIGVFFDACVFDLMFTGDDYLVHLSRAAESDFRRLAPHHFQSHVTQQHARFQKENQHKNHINQSEIFKKCIPSKSIRFYPFLAIFFFALLSLLC
Protein: Cellulose synthase A catalytic subunit 9 [UDP-forming] (EC 2.4.1.12) (OsCesA9) (A2Z1C8)
Organism: Oryza sativa subsp. indica (Rice)
Function: Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation (By similarity). Involved in the secondary cell wall formation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cellulose synthase
- Cellulose synthase A catalytic subunit 4
- COBRA-like protein 5
Sequence:
MEASAGLVAGSHNRNELVLIRGHEEPKPLRALSGQVCEICGDEVGRTVDGDLFVACNECGFPVCRPCYEYERREGTQNCPQCKTRYKRLKGSPRVPGDEDEEDIDDLEHEFNIDDEKQKQLQQDQDGMQNSHITEAMLHGKMSYGRGPDDGDGNSTPLPPIITGARSVPVSGEFPISNSHGHGEFSSSLHKRIHPYPVSEPGSAKWDEKKEVSWKERMDDWKSKQGIVAGGAPDPDDYDADVPLNDEARQPLSRKVSIASSKVNPYRMVIILRLVVLGFFLRYRILHPVPDAIPLWLTSIICEIWFAVSWILDQFPKWYPIDRETYLDRLSLRYEREGEPSLLSAVDLFVSTVDPLKEPPLVTANTVLSILAVDYPVDKVSCYVSDDGASMLTFESLSETAEFARKWVPFCKKFSIEPRAPEFYFSQKVDYLKDKVHPNFVQERRAMKREYEEFKVRINALVAKAQKVPAEGWIMKDGTPWPGNNTRDHPGMIQVFLGHSGGHDTEGNELPRLVYVSREKRPGFQHHKKAGAMNALIRVSAVLTNAPFMLNLDCDHYINNSKAIREAMCFLMDPQVGRKVCYVQFPQRFDGIDVHDRYANRNTVFFDINMKGLDGIQGPVYVGTGCVFRRQALYGYNPPKGPKRPKMVTCDCCPCFGRKKRKHGKDGLPEAVAADGGMDSDKEMLMSQMNFEKRFGQSAAFVTSTLMEEGGVPPSSSPAALLKEAIHVISCGYEDKTDWGLELGWIYGSITEDILTGFKMHCRGWRSVYCMPKRAAFKGSAPINLSDRLNQVLRWALGSVEIFFSRHSPLLYGYKNGNLKWLERFSYINTTIYPFTSLPLLAYCTLPAVCLLTGKFIMPPISTFASLFFIALFISIFATGILEMRWSGVSIEEWWRNEQFWVIGGVSAHLFAVVQGLLKVLAGIDTNFTVTSKATGDEDDEFAELYAFKWTTLLIPPTTLLILNIIGVVAGVSDAINNGSEAWGPLFGKLFFAFWVIVHLYPFLKGLMGRQNRTPTIVVIWSVLLASIFSLLWVRIDPFTIKARGPDVRQCGINC
Protein: GATA-type domain-containing protein (Q21636)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKSQPYTASSVTSTSTTHHPWMPISLREPPSKFQKLSTSDAAPLHNVCSSLKMKSTKPSRKRPSPKESDLPPLPSISTLFDSGSSSHSSSSSSNSSYGSYCQFSPEGSYTMYHWPMNYIPYVSPDVTITATTSTSTNAMASPDPIMLSSPPKQPTIEHTPINQPLFIQTADYPYDYSAPDPTGGYPSSATINANQLLLRPVPNGHV
Protein: Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] (Q00780)
Organism: Mus musculus (Mouse)
Function: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.
Interaction partners:
- Collagen alpha-2
Sequence:
MAVPPRPLQLLGILFIISLNSVRLIQAGAYYGIKPLPPQIPPQIPPQIPQYQPLGQQVPHMPLGKDGLSMGKEMPHMQYGKEYPHLPQYMKEIPPVPRMGKEVVPKKGKGEVPLASLRGEQGPRGEPGPRGPPGPPGLPGHGMPGIKGKPGPQGYPGIGKPGMPGMPGKPGAMGMPGAKGEIGPKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGAKGERGPKGPPGPPGLQGPKGEKGFGMPGLPGLKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGPPGEPGPQGLIGVPGVQGPPGMPGVGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGVGKPGFPGPKGDRGIGGVPGVLGPRGEKGPIGAPGMGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGVVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEGGHKGLPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIVGPSGPIGPPGIPGPKGEPGLPGPPGFPGVGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPTPSPQGEYLPDMGLGIDGVKPPHAYAGKKGKHGGPAYEMPAFTAELTVPFPPVGAPVKFDKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPMMYTYDEYKKGFLDQASGSAVLLLRPGDQVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM
Protein: Collectin-11 (Q5U3G1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (By similarity). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9BWP8}.
Interaction partners:
- Collectin-10 precursor
- Complement component 1, r subcomponent
- MBL-associated serine protease 1
Sequence:
MVGEKLVAYMLVSVLGLALLRSVFGQHMPEEPCSVQILVPGLKGEAGEKGEKGAPGRPGRVGPTGEQGPPGDKGQKGSPGRYGKMGPTGPKGLKGDMGDPGPKGPNGEPGVPCECAPLRKMIGEMDIQVVQLTNELKFIKNAVAGIKETDSKVYLLVKEEKRYREAEVFCQGRGGHLAMPKDAAANRAIAGYVTDAGLSRVYIGINDLEREGHFVYVERSPMTTFSRWREGEPNNAYDDEDCVEMVSSGEWIDVACQLTMYFVCEFDKDTV
Protein: Probable transcriptional regulatory protein (LuxR-family) (O53213)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Transcriptional regulatory protein EmbR
- HTH-type transcriptional regulator Cmr
- Transcriptional regulatory protein KdpE
- HTH-type transcriptional regulator Rv1931c
- Probable ECF RNA polymerase sigma factor SigI
- HTH hxlR-type domain-containing protein
- Transcriptional regulatory protein TcrA
- Transcriptional regulatory protein
- AB hydrolase-1 domain-containing protein
- Uncharacterized protein Rv1359
Sequence:
MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSELVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGVCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWYVNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAIELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRRLAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAWFAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAAAAAQASIDTAVGLSPVLSGSACSALVFATLAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWVPDILECLASVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGESERGPSRP
Protein: AT4g17070/dl4565c (Peptidyl-prolyl cis-trans isomerase) (Q93ZN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein DETOXIFICATION 45, chloroplastic
- RING-type E3 ubiquitin transferase
Sequence:
MPRRLNDGEPGRFTATVLLLIGLISCVIVYAVFSSVLRPSQDPTLVDSAVRFKEEPRDHDATEDGEGGCCRGIDNLELWGPAVKWGTDFKFNSSDGCCKACKVMCSGNDGPCLCDSWVFCGNKEDCGSKFGECWLKKQKDVLVPDRQGGGEKVMWTSGLIFGQGQGIVGFETEHGVIHVKLHPECAPHSVYYILSLLTLRHCAGCQFHRAENRGSYWDSEGNHVKNAPFGPPYAMIQGILQAEGNIFTPIPTEHCPTISRGSVAWVGSGPEFFISLANHHEWKQSYTVFGLVLPEDMDVVETIAGLPTRADVWNSVNVSVLEKPVSLTVRRMKTGQEQEETGS
Protein: SWIRM domain-containing protein laf1 (Clr6 L-associated factor 1) (O13719)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SWIRM domain-containing protein laf2
- Paired amphipathic helix protein pst3
- Set3 complex subunit hif2
- Transcriptional regulatory protein rxt3
- Histone deacetylase phd1
- SET domain-containing protein 3
- RbAp48-related WD40 repeat-containing protein prw1
- Putative histone deacetylase complex subunit cti6
- Uncharacterized protein C22E12.19
- Histone deacetylase clr6
Sequence:
MKSSQTLVYSIPRNVEKDTCAAAIKAYQYLISPPPSPIPNDKVASTVDVPKCSTIPESPKDSIVEPKPTATPVAQLHSKVYDLYRDSPKIWLRRERQWLQRHSPAYRFSTPAAKRPRRQPSSFLDVHASNTRKRGSPDTPDSGHSTPHSKGDVHPGMPQHNTRFKQSSREFSSNTQAIDVANTPYELLPDYSPDMSVLDKRSHPRPLRSEWKGPPLDLSNDENRHLLHPAELQLAATLRLPCLVYLDNKRRIFAEWHNRRTQGLSFRKTDAQRASRVDVNKASRLWKAFHDEGFFDD
Protein: ATPase inhibitor mai-2, mitochondrial (ATP synthase F1 subunit epsilon) (O44441)
Organism: Caenorhabditis elegans
Function: Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. Activity is pH dependent.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- F-ATPase gamma subunit
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit delta, mitochondrial
- Protein yippee-like B0546.4
- ATP synthase subunit d
- Oligomycin sensitivity conferral protein
- ATP synthase subunit alpha, mitochondrial
- Probable ATP synthase subunit g 2, mitochondrial
- ATP synthase F
Sequence:
MLSVSRAATRMTGMVARFSAGGHGDGAGRGGGSGGSIRDAGGAFGKMEAAREDEYFYKKQKAQLQELREHIQEEVKHHEGQLENHKKVLERHQQRISEIEAQERALGKE
Protein: FI20120p1 (Neurotransmitter transporter-like, isoform B) (Q8IPH3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAPDSACSCFITAFLIPYLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSDTDMESSK