wanglab/gogpt-training-data huggingface dataset:
Protein: B-lymphocyte antigen CD19 (Differentiation antigen CD19) (CD antigen CD19) (P25918)
Organism: Mus musculus (Mouse)
Function: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:20101619, ECO:0000269|PubMed:7543183}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:20101619}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Complement receptor type 2
- CD81 antigen
- Tyrosine-protein kinase Lyn
- Low affinity immunoglobulin gamma Fc region receptor III
- B-cell antigen receptor complex-associated protein alpha chain
- Proto-oncogene vav
- B-cell receptor CD22
- Tyrosine-protein kinase SYK
- Interferon-induced transmembrane protein 3
- B-lymphocyte antigen CD20
Sequence:
MPSPLPVSFLLFLTLVGGRPQKSLLVEVEEGGNVVLPCLPDSSPVSSEKLAWYRGNQSTPFLELSPGSPGLGLHVGSLGILLVIVNVSDHMGGFYLCQKRPPFKDIWQPAWTVNVEDSGEMFRWNASDVRDLDCDLRNRSSGSHRSTSGSQLYVWAKDHPKVWGTKPVCAPRGSSLNQSLINQDLTVAPGSTLWLSCGVPPVPVAKGSISWTHVHPRRPNVSLLSLSLGGEHPVREMWVWGSLLLLPQATALDEGTYYCLRGNLTIERHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSLVAFLYCQRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAAGLGSVPGSYGNPRIQVQDTGAQSHETGLEEEGEAYEEPDSEEGSEFYENDSNLGQDQVSQDGSGYENPEDEPMGPEEEDSFSNAESYENADEELAQPVGRMMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLHSIQSGPSHEEDADSYENMDKSDDLEPAWEGEGHMGTWGTT
Protein: Probable phospholipid-transporting ATPase tat-5 (EC 7.6.2.1) (G5EBH1)
Organism: Caenorhabditis elegans
Function: Plays a role in regulating membrane trafficking of cargo proteins during embryogenesis. Regulates snx-3 retromer-mediated endosomal sorting of mig-14, a transporter of Wnt egl-20 morphogen. Together with mon-2 and pad-1, may participate in the formation of endosomal carriers that direct mig-14 trafficking back to Golgi, away from lysosomal degradation. Required for Wnt egl-20 gradient formation along the anteroposterior body axis and migration of QL neuroblast descendants toward the posterior part. Maintains phosphatidylethanolamine (PE) asymmetry at the plasma membrane and prevents the budding of ectosome vesicles that affect intercellular communication and morphogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22100064}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Monensin-resistant homolog 2
- Protein pad-1
- Uncharacterized protein
- CDC50 family protein chat-1
- Cell cycle control protein 50A
Sequence:
MGKRKKNDESSSSSSQKPCVSSSSDDFSVSFVRAEEDDVATTIRDKTASLKSNATHFSAASAAKGGMFDFRCCRSLFSRRRVLHSRTVRVGYGPVGHDANVTFTPNTVCNQKYNIFSFVPIVLFQQFKFFLNLYFLLMACSQFIPAIQIGAPITYWGPLGFVLTITLIREAFDDFVRYLRDRDLNSEKYEKLTRDGTRIEIRSADIEVGDVIIMHKDRRVPADVVLLRTTDKSGACFIRTDQLDGETDWKLRIPVPHTQHLPNEADIMELNCEVYAEKPQKDIHAFVGTLKITDDDNVQDGSLNVENVLWANTVVASGTAVGIVVYTGRETRSVMNTTLPESKVGLLDLEVNNLTKLLFCFVLVLSSVMVAMKGLDNLWYRYLMRFILLFSYIIPISLRVNLDMAKLFYSWQIGRDKHIPETVIRSSTIPEELGRISFLLSDKTGTLTKNEMHFKKIHLGTVAFSSDAFEEVGQHVRSAYAGRLAKHSFSAKLQNAVEAIALCHNVTPIFENGEISYQAASPDEVALVKWTETVGVRLASRDLHAMSLSVQLPNGQTLMKQFQILYVFPFTSETKRMGIIVKDETTDEVTLLMKGADTVMSGMVQYNDWLDEECSNMAREGLRTLVVARKPLSQAELEAFDRAYHAAKMSISDRSQNMANVVNRMLERDLQLLCLTGVEDRLQDQVTTSLELLRNAGIKIWMLTGDKLETAICIAKSSGLFSRSDNIHVFGNVHNRTDAHNELNNLRRKTDVALVMPGSALNVCLQYYEAEVAELVCACTAVVCCRCSPEQKAQIVQLLRKYRAPLRVAAIGDGGNDVSMIQAAHAGIGIDANEGKQASLAADFSITQFSHVCRLLLVHGRFCYKRSCALSQFVMHRGLIISTMQAIFSCVFYFASVSLYQGVLMVAYSTCYTMLPVFSLVVDRDVTATNALTYPELYKELGKGRSLSYKTFCIWVLISLYQGAVIMYGALLVFDADFIHVVSISFSALIVTELIMVAMTVHTWHWAMLLAQALSLGLYMISLILFDQYFDRQFVLSWVFISKTTAITAVSCLPLYIVKALRRKFSPPSYAKVN
Protein: Ferredoxin--NADP reductase, leaf isozyme 2, chloroplastic (EC 1.18.1.2) (Leaf FNR 2) (FNR-2) (Os-LFNR2) (Q6ZFJ3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Plays a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power.
Subcellular location: Plastid, chloroplast stroma {ECO:0000250|UniProtKB:Q9FKW6}. Plastid, chloroplast thylakoid membrane {ECO:0000250|UniProtKB:Q9FKW6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9FKW6}; Stromal side {ECO:0000250|UniProtKB:Q9FKW6}.
Interaction partners:
- Protein TIC 62, chloroplastic
- Ferredoxin--NADP reductase, leaf isozyme 1, chloroplastic
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Ferredoxin-1, chloroplastic
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- Os05g0503300 protein.
- Os02g0765900 protein
- Os01g0357500 protein
Sequence:
MAAVNTVSSLPCSKAGAAVAGGAPRPSTCSVFYPPRCWSKRSSGNGVRAQASTTETTAAPAAEVTTKVEKVSKKQVDGVVTNKYRPKEPYTGRCLLNTRITGDDAPGETWHMVFSTDGEIPYREGQSIGVIPDGIDKNGKPHKLRLYSIASSAIGDFADSKTVSLCVKRLVYTNDQGEIVKGVCSNFLCDLKPGSDVKITGPVGKEMLMPKDPNATIIMLGTGTGIAPFRSFLWKMFFEEHDDYKFNGLAWLFLGVPTSSTLLYREEFERMKEIAPERFRLDFAVSREQTNAAGEKMYIQTRMAEYKDELWELLKKDNTYVYMCGLKGMEKGIDDIMIDLAAKDGIDWLDYKKQLKKSEQWNVEVY
Protein: Uncharacterized protein (A0A178UGH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MQTSRLLSFSSNSPSFGSFSSAVDLAAIAARVVEEFRDHDQTQSDSSPHRDDDNDSDFAFDCPSNTCSQPLATADEIFCNGQIRPLNPYGGNAPVESQPTSKITTLPPRRRRPALRKLMSEDRDPASNSSSEAEEDLTGVPPETYCVWKPKQSNSGDDDLQRLSSSPSHSKIKSHSAGFSKRWKLRNLLYVRSSSEGNDKLVFPAPVKKNDETVSDQREEEEPPSKVDGEEEGREREETKRQTYVPYRKDMIGILKNVNGLSRHLRPF
Protein: Krueppel-like factor 7 (Q99JB0)
Organism: Mus musculus (Mouse)
Function: Transcriptional factor. Plays a critical role in neuronal morphogenesis. Represses the corneal epithelium differentiation (By similarity). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75840}.
Interaction partners:
Sequence:
MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKASLSSVKVGGVAAAAAVTPAGAVKSGQSDSEQGGGGADTCPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI
Protein: E1 ubiquitin-activating enzyme (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) (O46111)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGNSAAAGGDIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADIAKNRAEASCAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQRIAKFGHENGIALIIAETRGLFAKVFCDFGETFTIYDPDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDLLTFSEVQGMQELNGCQPLKITVLGPYTFSIGDTSKFGEYMSGGVATQVKMPKTISFKPLAQATEEPEFLISDFAKLDSPATLHVAFNALSSYRKAHNGALPRPWNEEDANSFLEVVRASSNAEVDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLPTEGVEEADAQPVGSRYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKQCPDPLVFDVNDPMHLDFIYAAANLRAEVYGIEQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNADKSSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVLSGLACLEVIKLIVGHRDLVKFKKPCANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTGELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPHERSLVFEICCNDVDGEDVEVPYVRYTLP
Protein: Possible transposase (O07796)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible resolvase
- Possible resolvase
- Probable resolvase
- Possible resolvase
- Putative RNA-guided DNA endonuclease Rv2885c
- Probable transposase
- Uncharacterized protein Rv2886c
- Possible resolvase
- Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
- Possible transposase
Sequence:
MMARFEVPEGWCVQAFRFTLDPTEDQARALARHFGARRKAYNWAVATLKADIEAWRVTGIGTVKPSLRVLRKRWNTVKDEVCVNAETGAVWWPECSKEAYADGIGGAVDAYWNWQNSRSGKREGKTMGFPRFKKKGRDQDRVTFTTGAMRVEPDRRHLTLPVVGTVRTHENTRRIERLIATGRARVLAISVRRNGTRLDASVRVLVQRPQQPNVAQPGSRVGVDVGVRRLATVANEAGAVLEEVPNPRPLDTALKELRYASRARSRCTKGSRRYRERTTEISRLHRRVNDVRTHHLHVLTTRLAQTHGHIVVEGLDAAGMLRQKGLPGARARRRGLSDSALGTPRRHLSYKTGWYGSALVVADRWFPSLSVEPTVRPGLARLVAVKRGREAAAWLPNNPETGCKSRDH
Protein: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) (Q8NFP4)
Organism: Homo sapiens (Human)
Function: Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15922729}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15922729}. Note=Associated with lipid rafts.
Interaction partners:
- Neuroligin-2
- Fibronectin
Sequence:
MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR
Protein: [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) (A0A8I6AFH2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHRAVDPPGARSAREAFALGGLSCAGAWSSCPPHPPPRNSWLPGGRCSASIGQPPLSAPLPPSHGNSSGHPNKPYYASGTPTPRPLHGKLESLHGCVQALLREPAQPVLWEQLGQLYESEHDSEEAICCYHRALRYGGSFAELGPRIGRLQQAQLWNLHAGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRSAEPPVVQPMPPAALSGPSGEEGLSPGGKRRRGCSSEQAGLPPGLPLPPPPPPPPPPPPPPPPPPLPGLAISPPFQLTKPGLWNTLHGDAWGPERKGSAPPERQEQRHSLPHPHPYPAPAYTAHPPSHRLGPATPLGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPGTSSSSSSSNNTGLRGVEPSPGIPGADHYQNPALEIAPHQARLGPSAHSSRKPFLTAPAAAPHLSLPSGTPSSPPPPCPRLLRPPPPPAWMKGSACRSAREDGEILGELFFGAEGPPRPPPPPLPHRDGFLGPPNPRFSVGTQDSHTPPTPPTTTSSSSSSSSSNSHSSSPTGPVPFPPPPYLARSIDPLPRPSSPTLSSQDPPLPPLTLALPPAPPSSCHQNTSGSFRRSESPRPRVSFPKTPEVGQGPPPGSLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQQEAGAVPPPPLKEPFASLRSSLPSDTAPAATTAAATPTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPPPPPPASPASLLKSLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKPSVSSSSQFSTSGGPWVRERRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRACETLVERVGRSAINPADPVDIADPVDSGTEPQPPPAQAKEESGGVAVAAAGPGSGKRRQKEHRRHRRTCRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDVGGASKVKTPTTPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTSPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR
Protein: Uncharacterized protein C3orf67 homolog isoform 1 (Zgc:162324) (F1QDR3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- PARK2 co-regulated.
- Enkurin
- EF-hand domain family, member B
Sequence:
MFRNDYQGGLTVDIFSAQGKDPVAKWKLYGRKPSITKVFDKEVKGFVYSLEGNSQTHKMQLPKDSKMTLGLIQKFLILQVNIPLGKDFSAEFLVTDEEHLKRRLYLSTVHKELSATPLHARIPLTCHNRDTWCNLCIDLDSLTAVIFRGTRFLSLDGIIISACCKVRRIFTMKNEPADFTDREIRTGPKEEIPRSCQFPCEVQHVSQLVNMKTLGQTDGKSESSNGETEDTSGIKASITKGPTPRDSSHIAFGSKVIGPPPLTARKSSTSANTKEERFKSELSLNIPSGRSEKVQPRPPLEKPSAERTSSRRPQRIHNTKREKSCTDKEGGKISLNPEGSELQGKNAVSSLQTLGLDLTVEDKLTDPILQERVLTADDADLCDTETELSLSDEEYGEEVFTFSSCPHSARRNQASGNPVEDLTFGLKGHKLLTEGQRKDARLEDDFMGSESEEDEMHTEFLKRCAVHSITTPPPLSSIQKHTAQPKFSSEPIKTRASAVQHVSEGPKRHEPMRIAPTRCLSPSSSRQGSRLDRSEADRALPDGDTRISINRTSVREISLKNSGLQKVSVDGRVQPLGSSRCDLRSQDEEDEEDELRMLACLKREQEEEGDISSPGLSASQVHHCDISLSASSDDTSTWTQCIPLPVDQGQHYQKEMNPLLHSNPREWMDVLSPPIVHPNQQMADGKGDHKVSTRGSKLHDNSEEEEFLNLMYDSCLNCYFDPQSGKYYELL
Protein: Bacterial microcompartment shell protein EutL (BMC-T) (Ethanolamine utilization protein EutL) (P0A1C9)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: A component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation. Forms a hexagonal trimer with 3 small channels and a large central pore that has been seen in both open and closed forms and is probably used for gated transport into and out of the BMC (By similarity). Ethanolamine-binding by the small channels has been hypothesized to stabilize the EutL central pore in a closed (non-transporting) state. An open pore is thought to be large enough to transport ATP and/or cobalamin (By similarity). Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC. Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo.
Subcellular location: Bacterial microcompartment {ECO:0000269|PubMed:27063436}.
Interaction partners:
- Ethanolamine ammonia-lyase small subunit
- Ethanolamine ammonia-lyase reactivase EutA
- Ethanolamine ammonia-lyase large subunit
- Bacterial microcompartment shell protein EutS
- Bacterial microcompartment shell protein EutK
- Probable ethanolamine permease EutH
- Bacterial microcompartment shell vertex protein EutN
- Bacterial microcompartment shell protein EutM
- Acetate kinase EutQ
- Ethanolamine utilization protein EutJ
Sequence:
MPALDLIRPSVTAMRVIASVNDGFARELKLPPHIRSLGLITADSDDVTYIAADEATKQAMVEVVYGRSLYAGAAHGPSPTAGEVLIMLGGPNPAEVRAGLDAMVASIENGAAFQWANDAENTAFLAHVVSRTGSYLSSTAGIALGDPMAYLVAPPLEATFGIDAAMKSADVQLVTYVPPPSETNYSAAFLTGSQAACKAACNAFTDAVLDIARNPVQRA
Protein: Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) (Q9H0U9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Interaction partners:
- Testis-specific Y-encoded-like protein 2
Sequence:
MSGLDGVKRTTPLQTHSIIISDQVPSDQDAHQYLRLRDQSEATQVMAEPGEGGSETVALPPPPPSEEGGVPQDAAGRGGTPQIRVVGGRGHVAIKAGQEEGQPPAEGLAAASVVMAADRSLKKGVQGGEKALEICGAQRSASELTAGAEAEAEEVKTGKCATVSAAVAERESAEVVKEGLAEKEVMEEQMEVEEQPPEGEEIEVAEEDRLEEEAREEEGPWPLHEALRMDPLEAIQLELDTVNAQADRAFQQLEHKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSAMIRGQDAEMLRYITNLEVKELRHPRTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVSLSTPIIWRRGHEPQSFIRRNQDLICSFFTWFSDHSLPESDKIAEIIKEDLWPNPLQYYLLREGVRRARRRPLREPVEIPRPFGFQSG
Protein: Xaa-Arg dipeptidase (D4AAB5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGPVVERPAERCTSSATELELLKQRAAERIDEAAERLGALSRAIWSAPELAYEEHRAHGELTRFFEREPPAASWAVQPHFGLPTAFRAEWAPPEAAAGPGALQLAFLCEYDALPALGHACGHNLIAEVGAAAALGLRAALESIAAPPPVKVIVLGTPAEEEGGGKIDLIKAGAFENLDVVFMAHPSQENAAYLPDVAEHDVTVKYYGKASHAAAYPWEGVNALDAAVLAYNNLSALRQQMKPTWRVHGIIKNGGVKPNIIPSYSELLYYFRAPSMKELHVLTKKAEDSFRAAALATGCTVEIKSEAHDYYNVIPNKTLCSAYMENGKKLGVEFISEDAVLNGPSGSTDFGNVSFVVPGIHPYFYIGTDALNHTEEYTEAAGSQAAQWYTLRTAKALAMTALDVIFKPQLLEGIRKEFKSKLQEEQLLNTPA
Protein: Serine protease inhibitor A3N (Serpin A3N) (CPI-26) (Contrapsin-like protease inhibitor 6) (SPI-2.2) (Serine protease inhibitor 3) (SPI-3) (P09006)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MTRLVTLELLMAGIGSALLCFPDCILGEDTLFHEDQDKGTQLDSLTLASINTDFAFSLYKKLALRNPDKNVVFSPLSISAALAVVSLGAKGNSMEEILEGLKFNLTETPETEIHRGFGHLLQRLSQPRDEIQISTGNALFIEKRLQVLAEFQEKAKALYQAEAFTADFQQSREAKKLINDYVSKQTQGKIQGLITNLAKKTSMVLVNYIYFKGKWKVPFDPRDTFQSEFYSGKRRPVKVPMMKLEDLTTPYVRDEELNCTVVELKYTGNASALFILPDQGKMQQVEASLQPETLRRWKDSLRPSMIDELYLPKFSISADYNLEDVLPELGIKEVFSTQADLSGITGDKDLMVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLDPLIIAFDRPFLMIISDTETAIAPFLAKIFNPK
Protein: Uncharacterized protein YJL133C-A (Q3E7A3)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:16823961}; Single-pass membrane protein {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Lipid-anchored plasma membrane protein CPP3
Sequence:
MIAQSTRLAAAVSSSAASAGVSRIAASAMASTIFKRSPGNSFNSFKEYRENAKTYGPLSASLATRRHLAHAPKL
Protein: Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) (Q9H6Q3)
Organism: Homo sapiens (Human)
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Subcellular location: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Huntingtin-interacting protein 1-related protein
- Sarcolemmal membrane-associated protein
- Talin-1
- Talin-2
- Huntingtin
- Clathrin heavy chain 1
- Epidermal growth factor receptor
- Clathrin coat assembly protein AP180
- Tyrosine-protein kinase ZAP-70
Sequence:
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA
Protein: SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) (O94885)
Organism: Homo sapiens (Human)
Function: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23333244}.
Interaction partners:
- Sterile alpha motif domain-containing protein 5
Sequence:
MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
Protein: Non-structural protein 1 (NS1) (I6T1Z2)
Organism: Influenza A virus (strain A/Aichi/2/1968 H3N2)
Subcellular location: Host nucleus {ECO:0000256|RuleBase:RU362113}. Host cytoplasm {ECO:0000256|RuleBase:RU362113}.
Interaction partners:
Sequence:
MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQKSLRGRGSTLGLNIEAATRVGKQIVERILKEESDEALKMTMASAPASRYLTDMTIEELSRDWFMLMPKQKVEGPLCIRIDQAIMDKNVMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWGSSNENGRPPLTPKQKRKMARTVRSKVRRDKMAD
Protein: At5g17610 (Q67Y04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEISQARSSFVCLLLLLLSMCFVPCVFSKSPRPISDVEIRQKKSECYGDIESGLWGWQCKSSAIAKENCALRCLSPVCYQLIYESDPLEEGEKDLIRSQEYKYCMYKSSLGESLEGVRGIF
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-zeta-1) (Phospholipase C-zeta-1) (PLC-zeta-1) (Q5FX52)
Organism: Rattus norvegicus (Rat)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
Interaction partners:
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Inositol polyphosphate multikinase
- Inositol polyphosphate-5-phosphatase A
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
- Protein kinase C gamma type
- Protein kinase C beta type
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Sequence:
MESHYELAEARWFMSKIQDYFRGGKISAGITHKLLEKLDFPCHFAHVKRIFKENDRHNQGRITTEDFRTIYRCIVHREEIVEIFNTYTENRKILPEDSLIEFLTQEQYEMEMDESSSVEIIQKYEPIAEVKNERQMSIEGFARYMFSSECLLFKETCNTVYQDMNKPLNDYYISSSHNTYLISDQILGPSDIWGYISALVKGCRCLEIDCWDGAQNEPIVYHGYTLTSKLLFKTVIQAINKYAFVTSDYPVVLSLENHCSPGQQEVMTDILQSTFGDFLLSDILDEFPDSLPSPEALKFKILVKNKKVGTLSETRERLGTDKRGIALDLEEEIYENEDEDSGKEPETWDDFLSRVKEEQEADPSTLSGIADAKKKIRKLRVALALSDLVIYTKAEKFRNFQYSRVYQQFNETTSMGESRARKLSKLRAHEFIFHTAAFITRVYPKFTRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYVLKPDFLRDTTLGFNPNEPEGDGHPVTLTIRLISGIQLPVNVPSNTSDIIVIIEVYGVPNDHMKQQSRAVKNNAFSPRWNETFTFLIQVPELALIRFVVETQGFLSGNELLGQYTLPVLCMNKGYRRVPLFSKSGANLEPSSLFIYVWYYRE