Protein: Ectopic P granules protein 5 (Q18892)
Organism: Caenorhabditis elegans
Function: Involved in the maturation of autophagosomes into autolysosomes during starvation-induced autotrophy. Specifically, involved in the clearance of apoptotic cells by promoting the delivery of engulfed apoptotic cells to the lysosome.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20550938}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:22451698}; Peripheral membrane protein {ECO:0000305|PubMed:20550938}; Cytoplasmic side {ECO:0000305|PubMed:20550938}. Note=Partially localizes to the phagosome membrane of engulfed apoptotic cells. {ECO:0000269|PubMed:22451698}.
Interaction partners:
- Ectopic P granules protein 3
- Protein lgg-1
- Ectopic P granules protein 4
- Autophagy-related protein 5
- Soluble NSF attachment protein 29
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy-related protein 2
- Autophagy-related protein 18
- Ectopic P granules protein 6
- V-SNARE coiled-coil homology domain-containing protein
Sequence:
MAELVRPKKPKHRERAQSDYTPPIPDRPAIVNGLRLPAAPSHTIEDLPERSASPEPEDQDISLTEDSLKREEASEPLKDVRSSPVRPAPPPPRVSQEREAPPIPPRSMIFPRSTSMVAESRKESTTAVAPKRSVAVASYPAVPELAELPSYTDALQHPQVYPSINGGLQHSHSATAIPEKTRFSAPVERERVREGEAPPMYPSIKTYERNEHGLMTEENLVTFYHNPLYEHAEMFVDQFIKTEEVPTQSGSLFPLLARLRTVCDLMTVSEVKGKENTEELQKCLRECWVQQSLSVDAKGKCGDNNDGTGRASYFSFELQQAVLDQMKKLLSTNRSNLMDHSVCEETSFRSIALQIQWQVIIINNNFMAENGLSTNCPPSLIASVPMTPGRVALRTALSDIFYHLRYPRLSKRFIDTLVGWIKELTCVLNMRQSCDDGIFLLCHLLRLPSPIDQWASPFVQTFIQSQSAPKLKLDYCVALLTHLLNPIKARESFLRHVAQSEKEESTWEILADDDDGEANEFSFVTINESDLTAFLDQFPISELYSIAYLAFTSYSDKGSQFTAMIAFQLLLMKILDNGLTSYSQPGYKMFCKQIGISLKHSVRELCSNWRLIRDQVRPGEEHHLQKEVDRVVLLALNYLIHQDTLGLFQFVVSLPYAVVSEECRSRCEYALRSNKKMSIHEIYDTPICEVRARISSQGISKRIGALGAQDSEFLVNSLASIGSYSNSDVSQLLKELIDVCFCDEDTRDDLYKCGGEAIGQILIKRPETLHQLLTIIDRNLQHMDSYAINVLSSSRLFECRLTEPMISIIGKWLINNPPEHGANRLARRVLSGLHWGLAVDGHNLWIDVDVHTIAADTVVKAHSVHCSRSNSMISKSINKISKLASKVGDAESLFQQFCWDLLVKLKLPTIPSSLVQNDLTAHYVRIVQNCEDDVVVYLEKGVPLLSDLVTSGSSVASVVLLSRLIAQHYQNVNLMAADKNFMTTFERLLHIDQLPYAVQWLSGPSSTPTPIVKLICSAISYYSAKLPPRDYLRAWITLLCAARTGWNEDAVTYQIVGTIARIAFVNDTHKLYEITGIIFQAYQQQLAAEKNQSKGIMSMFSSDNTVSPLIPDSMLSISPFASYVMLRVEQKSFNTFYGHFFETLTKKDKYTLDNAVKKASSKCSITVPVERLAIFRWAKLVTVCNDHQLLPILLQQLSGSAYRLRKANNLNLCYARRLIDDPQMQDVMAACRKAIEESTIETKGLSKAVVGWLFTKHEVTRTGFDFSVFDLDYLLQLILAGDKNMWLDFVNMPYFNSEEFSERKLYSVTCQLSPKNRESPLPPEIGSPRSRSSAKPFPVLPVHSGLPQAPLIDPSILFQQHTVLQLASPFINTIKQLSKQFAQSGDRMSMDDDSYCKQIKALYQPTQQTIPVEIRCSYCSKPKACTMSIKPNVLNSEIDLQMTQNRTKRFEFWNELYASIVDKAAVATASIEHLSVLVAKMTSALHPGTRNNVQLTGHSLFYLITSSVGENELLFSVASDSFCNSLRSLGEEYVKFRPEEQMDVMQLALDGFVLSEPLVEVFTPEVLNSDDLCTAYRKLSDAVRMPERSKMALQLLGRLGMQQAAAGLPPHQFAALLPIAFANLASQPDPSSPLHALCLQHVIFFVFHHFPDNIVNGLDLTLDGCNTNSTPASLLDAIVDKLDANDYLKKKNSFDLGAAKADECARILSKRLDEARTKLPNFYGIWSRYLDSVTRLAQLFLFVPIRDGYEPNKSVSVLQRECYEYFTRVAAVFSPLIAPYSPTHPPFSTSHEAQAMLVLDRFVDFLSALHFNSSIPPGMQNIQSLVWQYYCEKLSILTHGTQHYYDVIERQLVRLNWQALWPSRLAITAMENCLDTRSQDCASFISQMVARIPWSNILQTMHEDSRPSYLASLFGVLVRLAARPRNYDKVRASLLELCKSFSLRSDWNKIYPEDAAGIASAVTKCLPSDSLSNPVEMVSVIQVIWRKICCFVVREPFSEVSLQKQKLWIQTESSLLLKAESSQIPAAYNSLISDVNALALNHSNLREFRVVTRELTAMWKNITDAKLGEALVSIWSEYLAANPTSPLVLTSVNTLVDSLNIDQLTTALKVIEKVICAYFLRTDSNWAELLHWIQFPTGSLKSIKSYLMTVPSSENKVQMLPLTLKIFMDYGGVDENKFFDLHHYVISIRPKHVASESGFICLLARHLQWMANRSSALPAHFAPSDDLLSSLIKYLGKASKDESSFLTALISSKKTAYSQKMRVTLHILELYLTQQTLGEGKRPRCDANSPVLNSRISTLKDLAQQKSNQNMSNAFNKATAYFVQIETHRIQSSPKLLLEIGRSAFGDLFLTD