Protein: Extracellular matrix organizing protein FRAS1 (Q80T14)
Organism: Mus musculus (Mouse)
Function: Involved in extracellular matrix organization. Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development. Involved in brain organization and function.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12766769, ECO:0000269|PubMed:32333816}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:12766769, ECO:0000269|PubMed:32333816}.
Interaction partners:
- FRAS1-related extracellular matrix protein 1
- FRAS1-related extracellular matrix protein 2
- Integrin alpha-8
- Integrin beta-1
Sequence:
MGVLKAWLGVALALAEFAVLPNCEGACLYQGSFLADATIWKPDSCQNCRCHGDIVICKPVVCKNPRCAFEKGEVLWIAPNQCCPQCAPRTPGSCHHEGKIHEHGTEWASAPCTVCSCTHGEVRCSHQQCTPLSCGPQELEFLAEGRCCPICVGTGKPCSYDGHVFQDGEDWQLSRCAKCVCRNGLTQCFAAQCQPLFCNQDEIVVRVPGKCCSQCSARSCSTAGQVYEHGEQWKEDACTLCMCDQGQVRCHKQVCPPLRCAKGQGRARHHGQCCEECATPDRSCSSGGVLRYQDEMWKGSACEFCMCDQGQVTCQTGECAKVACALGEELVHLEGKCCPECISRNGYCIYEQKAETMSSSAREIKHVPDGEKWEEGPCKLCECREAQVTCYEPSCPPCPVATLALVVKGQCCPDCTPVHCHPDCLTCSHSPDHCDLCQDPTKLLQNGRCVHSCGLGFYQAGSLCLACQPQCSTCTNGLECSSCLPPLLMQQGQCVSTCGDGFYQDHHSCAVCHESCAGCWGPTEKHCMACRDPLQVLRDSSCENTCGNGFYNRQGTCVACDQSCKSCGPSSPRCLSCAEKTILHDGKCISECPHGYYADSTGSCKVCHSSCASCSGPTAAHCIACIHPQTLRQGHCLPSCGEGFYPDHGICEACHASCHTCVGPQPSHCTQCKKPEAGLLVEQHSGENVPYGKCVSRCGTHFYLESTGLCEVCHPSCLTCEGKSPHNCTGCESTHALLAGCCVSQCPETHFNLEGTCTECHPSCRQCHGPLESDCVSCHPHLTLTSGHCKTSCKEEQFLNLVGYCADCHPLCQHCVANLQDTGSICLKCQHARHLLLGDHCVPECPPGHYKERGTCKTCHSSCRSCQNGGPFSCSSCDTGLVLTHIGTCSTACFPGHYLDDNQVCQPCNRHCRSCDSQGSCTSCRDPSKVLLFGECQYESCTPQYYLDIATKTCKECDWSCNACTGPLRTDCLQCMDGYVLQDGVCVEQCSPQHYRDSGSCKRCDSHCVECQGPHECTRCEEPFLLFQAQCVQECGKGYFADHAKHRCIACPQGCLRCSHKDRCHLCDHSFFLKSGLCMPTCVPGFSGHSSNENCTDKMYTPSLHVNGSLTLGIGSMKPLDFSLLNIQHQDGRVEDLLFHVVSTPTNGQLLLSRNGKEVQLEKAGHFSWKDVNEKKVRFVHSKEKLRKGYFSLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHVSKGERATITTQLLDIRDDDNPQDVVVNVLDPPLHGQLLQMPPAPAASIYQFHLDELSRGLLLYAHDGSDSTSDIIVFQANDGHSFQNILFHVKNIPKNDRALRLVTNSMVWVPEGGMLKITNRILKAQAPGVRADDIIYKITHSRPQFGEVVLLMNLPADSPAGPAEEGHHLPDGRMATPISTFTQQDIDDGVVWYRHLGAPTQSDSFRFQVSSATSAQEHLESHMFNIAILPQAPEAPKLSLGTSLHMTAREDGLSVIQPQSLSFVKAESPSGKIIYNITVPLHPNQGIIEHRDRPHSPIQYFTQEDINQGQIMYRPPVAPPHLQEIMAFSFAGLPESVKFYFTVSDGQHTSPEMALTIHLLHSDLQPPAFQVKAPLLEVSPGGRTSLGLQLLVRDAQVVPEELFFQLQKSPQHGMLVKYTAKSSVTMAAGDTFTYDEVERNVLQYVHDGSSAWEDSLEISVTDGLTVTTSEVKVEVSPSENRGPRLAPGSSLSMTVASQHTAIITRSHLAYVDDSSSDPEIWIRLSSLPLYGVLFRSSGPDMDELSGDSNFTMEDINKKNIRYSAVFETDGHSVTDGFHFSVSDMDGNHVDNQVFTITVTPAENPPHIIAFADLITVDEGGRAPLSLHHFFATEDQDNLQDDAVIKLSALPKYGCIENTGTGDRFGPGANSELEASFPIQDVLENYIYYFQSVHESIEPTHDVFSFYVSDGSGRSEIHSINITIERKNDEPPRMTLRPLGVRLSSGVAISNSSLSLQDLDTPDNELIFVLMKKPDHGHLLRRSTASDPLENGTVLDQGSSFTYQDVLAGLVGYLPGDIYMAVDEFRFSLTDGLHVDTGRMEIYIELPSTNIPHLAINRGLQLSAGSVARITEQHLKATDTDSEAGQVVYIMKEDPGAGRLLMAKADNLEQISVRGPIRSFTQADVSQGQIEYSHGPGEPGGSFAFKFDVVDGEGNKLADQSFSIGVLEDKSPPVVITNRGLVLDENSVEKITTAQLSATDQDSKPTELIYRITTQPQLGHLEHVASPGIQISSFTQADLASRNVQYVRSSGTGKQSDAFSFVLSDGLHEVTQTFPITIHPVDDARPLVQNRGMRVQEGVRKTITEFELKAVDVDTEAESITFTIVQPPRHGTIERTARGQRFHQTSSFTMEDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGEEIMTAAPQQFHVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTVDPDTEDSQLIYEVTTGPMHGYLENKLQPGRAAATFTQEHVNLGLIRYVLYEEKIQKVMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSHPGQQDYMEYAGQVQFDEGEGTKSCTVIINDDDVFENIESFTVGLSMPAYALLGEFTQAKVVINDTEDEPTLEFDKKTYRVNESAGFLFAPIKRQGDSSSTVSAVCYTVPKSAMGSSLYALESGSDFKSRGRSAESRVIFGPGVTVSTCDVMVIDDSEYEEEEEFEIALADASNNARIGRQAVAKVLISGPNDASTVSLGNTAFTISEDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRKVEFGPGITEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPSQAVIAINDTFQDVPSMQFSKDLLLVKEKEGVLHIPIIRSGDLSYESSVRCYTQGHSAQVMEDFEERRNADSSRITFLKGQKTKNCTVYIHDDSMFEPEEQFRVYLGHPLGNHWSGARIGKNSVATVTISNDEDAPTIEFEEAAYQVREPAGPEAIAVLSIKVIRRGDQNRTSKIRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDLVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEELAKEGVKKAPSPGYPLVCVTPCDPRYPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGARSPFETITDNTPFTSVNHKVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNVVTIGTDSAICHTPVVAGTARGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLHNLHFLLSESIYRHQHVCSNLVTAQDLRGLAEAGFLNDAGFHSTALGPGYDRPFQFDSSVREPKTIQLYRHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAKFRGQFVIEHHTLPDVKSFILTPDHLGGIQFDLQLLWSAQTFDSPHQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWVDPGEKALACTAHAPERFLIPIAFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLHSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRSQPEVTDKYFHDVPFEAHFASELPDFQVVSSMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDSTSRPRVQRSLTVSLRRHQRDLVDPSGWLSLDDSLIYDNEGDQVKNGTNMKSLNLEMQEPVIAASLSQTGASIGSALAAIMLLLLLFLVACFVTRKCQKQKKKQPPEDTLEEYPLNTKVDVAKRNADKVEKNANRQYCTVRNVNILSDNEGYYTFKGAKVKKLNLEVRVHNNLQDGTEV