wanglab/gogpt-training-data huggingface dataset:
Protein: Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5) (Q9UPR3)
Organism: Homo sapiens (Human)
Function: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Interaction partners:
- Regulator of nonsense transcripts 3B
- Regulator of nonsense transcripts 1
- Regulator of nonsense transcripts 3A
- Nonsense-mediated mRNA decay factor SMG7
- Telomerase-binding protein EST1A
- Serine/threonine-protein kinase SMG1
- Regulator of nonsense transcripts 2
- Proline-rich nuclear receptor coactivator 2
- Nonsense-mediated mRNA decay factor SMG8
- Polyadenylate-binding protein 1
Sequence:
MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
Protein: Possible lipoprotein LprC (O86337)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative lipoprotein LprB
- Large ribosomal subunit protein bL19
- Probable conserved membrane protein
- Large ribosomal subunit protein bL17
- Large ribosomal subunit protein bL20
- Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW
- Large ribosomal subunit protein bL27
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL2
Sequence:
MRRVLVGAAALITALLVLTGCTKSISGTAVKAGGAGVPRNNNSQERYPNLLKECEVLTTDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGSLSNERKVAEGLKYQVETRAIQGVDSIVMRTGDPNGACGVASDAAGVVGWWVNPQAPGIDACGQAIKLMELTLATNA
Protein: F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (Q8BH70)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UKA2}. Nucleus {ECO:0000250|UniProtKB:Q9UKA2}. Mitochondrion outer membrane {ECO:0000269|PubMed:38359748}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MSPVFPMLTVLTMFYYMCLRRRARTATRGDMMNSHRTIVSNSRTSPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFRRTPSSFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERPMKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLDYYTELDAVVLHGTKDKPLLSLKTALVDMNDLEDDDYEEKDGCEMDALNKKFSSAALGDGPHNGYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIHLNLQPYWARLDDTSLEFLQARCVLVQWLNLSWTGNRGFISVSGFSRFLKVCGSELVRLELSCSHFLNDTCLEVISEMCPNLQDLNLSSCDKLPPQAFGHIAKLCSLKRLVLYRTKVEQTALLSILNFCAELQHLSLGSCVMIEDYDVIASMIGAKCKNLRTLDLWRCKNITENGIAELASGCVLLEELDLGWCPTLQSSTGCFVRLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNKAVLELNASFPKVFIKKSFTQ
Protein: thioredoxin-disulfide reductase (EC 1.8.1.9) (H0YBQ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
LERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCCG
Protein: Envelope glycoprotein (Q75170)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Subcellular location: Virion membrane {ECO:0000256|ARBA:ARBA00004182}.
Interaction partners:
Sequence:
VVIRSENFTNNAKTIIVQLNESVVINCTRLNNNTRKSITIGPGRAFYTTGGVIGDIRQAHCNLSEATWNATLKRVAEKLREQFGNKTIVFNQSS
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9VBM6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Don juan like
- Uncharacterized protein, isoform A
- Uncharacterized protein, isoform C
- FI08238p
- IP12902p
- FI08446p
- GEO02361p1
- Reticulon-like protein
- Glutamate transporter polyphemus
- FI23334p1
Sequence:
MCIVNDWCREYANLYPKKAVSIGHPLSVIFLLVSTVFFFTLQVFYVAPDVHDGFMYKFFVISAIFTTYNILGNLLACYRTSSAVKSLPQERQIPKPGTEHLWHYCDICQKLMPPRSWHCALCKCCILKRDHHCIFAATCIGHNNHRYFFWLTFYLAFGIFMSMATLFVDVGRSFYLLHRMKAGFGNTVKSLSYFRYVCLILNIFALGFPALMLRFQVQILKLNSTYYQISSRHHDLGFRNNCQLIMGQRGLWTFISPSLRSPLPHDGTHWKIKQCF
Protein: DNA repair protein XRCC2 homolog (X-ray repair cross-complementing protein 2 homolog) (AtXRCC2) (Q682D3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein RAD51 homolog 3
- DNA repair protein XRCC3 homolog
- DNA repair protein RAD51 homolog 4
- DNA repair protein RAD51 homolog 2
- Meiotic recombination protein DMC1 homolog
- DNA repair protein RAD51 homolog 1
- DNA repair protein recA homolog 1, chloroplastic
- Crossover junction endonuclease MUS81
- Double-strand break repair protein MRE11
- DNA repair protein RAD50
Sequence:
MGDDEARSWIRGDETAKQMLSRVLKDRAFLLIPPLHRVPLRAGNVVEITGASTSAKTQILIQAAISCILPKTWNGIHYGGLGKLVLFLDLDCRFDVLRLSQMLKHRLLQANWLGNGAWWQLEESNVKSCKSAEEKTKTVFDEELYASCMKRFLYVRCYDSLELLSSLKTLHYRIQQQEACGSQVGVLMIDSIGAFHWTDRLSSSLALETHNRKSLSLTNVVETIVQELKKLLLVHSLVVLATKGTIYEEKYPANENNRKVSSNDHFSGNVASKAQQPPFREFMPSSWQAFVTHKIIIRKSADYQSLQTGQQNLLAYSLEWLQPQLSRIDRFIVDDVRKLTTIKPFYSKLLLIYIVIPASSSHAVWYCHCLVT
Protein: Glycine betaine uptake system permease protein YehY (P33361)
Organism: Escherichia coli (strain K12)
Function: Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycine betaine-binding protein YehZ
- Glycine betaine uptake system ATP-binding protein YehX
- Glycine betaine uptake system permease protein YehW
- Glycine betaine/proline betaine transport system ATP-binding protein ProV
- Uncharacterized protein YhjY
- Uncharacterized protein YehE
- Potassium binding protein Kbp
- Glycine betaine/proline betaine-binding periplasmic protein
- Uncharacterized protein YcgB
Sequence:
MTYFRINPVLALLLLLTAIAAALPFISYAPNRLVSGEGRHLWQLWPQTIWMLVGVGCAWLTACFIPGKKGSICALILAQFVFVLLVWGAGKAATQLAQNGSALARTSLGSGFWLAAALALLACSDAIRRISTHPLWRWLLHMQIAIIPLWLLYSGTLNDLSLMKEYANRQDVFDDALAQHLTLLFGAVLPALVIGVPLGIWCYFSTARQGAIFSLLNVIQTVPSVALFGLLIAPLAALVTAFPWLGTLGIAGTGMTPALIALVLYALLPLVRGVVVGLNQIPRDVLESARAMGMSGAQRFLHVQLPLALPVFLRSLRVVMVQTVGMAVIAALIGAGGFGALVFQGLLSSAIDLVLLGVIPVIVLAVLTDALFDLLIALLKVKRND
Protein: F420H(2)-dependent quinone reductase Rv1558 (Fqr) (EC 1.1.98.-) (P9WP11)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the membrane fraction of M.tuberculosis.
Interaction partners:
- F420-dependent glucose-6-phosphate dehydrogenase
- Probable transport protein MmpL6
- L-threonine dehydratase biosynthetic IlvA
- Phosphoenolpyruvate transferase
- F420H
- Bifunctional F420 biosynthesis protein FbiB
- Phosphoenolpyruvate guanylyltransferase
- Possible oxidoreductase
- Putative coenzyme F420-dependent oxidoreductase Rv3520c
- Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase
Sequence:
MPLSGEYAPSPLDWSREQADTYMKSGGTEGTQLQGKPVILLTTVGAKTGKLRKTPLMRVEHDGQYAIVASLGGAPKNPVWYHNVVKNPRVELQDGTVTGDYDAREVFGDEKAIWWQRAVAVWPDYASYQTKTDRQIPVFVLTPVRAGG
Protein: Cellulose synthase (A6MUT5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
DRSDRYANRNTVFFDVNMKGLDGIQGPVYVGTGCVFNRQALYGYGPPSMPSFPKSSSSSCSCCCPGKKEPKDPSELYRDAKREELDAAIFNLREIDNYDEYERSMLISQTSFEKTFGLSSVFIESTLMENGGVAESANPSTLIKEAIHVISCGYEEKTAWGKEIGWIYGSVTEDILTGFKMHCRGWRSIYCMPLRPAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPLWYGFGGGRLKWLQRLAYINTIVYPFTSLPLIAYCSLPAICLLTGKFIIPTLSNLASVLFLGLFLSIIVTAVLELRWSGVSIEDLWRNEQFWVIGGVSAHLFAVFQGFLKMLAGIDTNFTVTAKAADDADFGELYIVKWTTLLIPPTTLLIVNMVGVVAGFSDALNKGY
Protein: RING finger protein OIP1 (Q8R4E3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRPWEMTSNRQPPSVRPNQHHFSGERCNTPARNRRSPPVRRQRGRRERLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLLHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLQVGSFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPVPPPTYHPSLLPYVLSMLPVPPTVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPFYRFNPSNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKGNRTCPICRADASEVHRDSE
Protein: Afadin (Afadin adherens junction formation factor) (Protein Af-6) (Q9QZQ1)
Organism: Mus musculus (Mouse)
Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity).
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
Interaction partners:
- Tight junction protein 2
- GTPase HRas
- GTPase KRas
- Tight junction protein 1
- Nectin-3
- Catenin delta-1
- Nectin-1
- Nectin-2
- Junctional adhesion molecule A
- GTP-binding protein REM 1
Sequence:
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPAKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKKEKEALRQASDKEERPSQGDDSENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDTADFAVAESLEKYGLEKENPKDYCIARVMLPPGAQHSDERGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDYIPKKMKKHVEGKSLKGKDRADGSGYGSALPPEKLPYLVELSPGRRNHFAYYSYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKFDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVDGQRISETTMLQSGMRLQFGTSHVFKFVDPIQDHVLSKRSVDGGLMVKGPRHKPGAVQETTFELGGDVHSGTALPASRSTTRLDSDRVSSASSTAERGMVKPMIRLDQEQEYRRRENRTQDATGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSSQHRPDISPTERTHKAIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYVPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVAVAENTADELARSDGRDVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLVPHTRSPGTWTIYFEGADYESHLMRENAELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSAQNGSPESPQMPWTEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKGPYTSGTAAKITSVSTGNLCTEEQSPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQSQWPNYEEKPHVHTESNHSSIAIQRVTRSQEELREEKVYQLERHRVEAGMDRKCDSDMWINQSSSVESSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAVLPTPVAVSQPIRTDLPPPPPPPPVHYTSEFDGIPMDLPLPPPPANQAGPQSAQVAAAEWKKREEHQRWYEKEKARLEEERERKRREQERKLGQMRSQTLNPASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQPRTIERKDLQYITISKEELSSGDSLSPDPWKRDAREKLEKQQQMHIVDMLSKEIHELQNKVDRTAEESDRLRKLMLEWQFQKRLQESKQKDEDDDEEEDDDVDTMLIMQRLEAERRARMQDEERRRQQQLEEMRKREAEDRVRQEEDGRHQEEERVKRDAEEKRRQEEGYYSRLEAERRRQHEEAARRLLEPEEPGLSRPPLPRDYEPPSLSSAPCAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYDEEEEDYGPAGPNSYSGSAGTAVGAYDAPREAREKLTRSQDADLPGSSGAPENLTFKERQRLFSQGQDVSDKVKASRKLTELENELNTK
Protein: Calcium permeable stress-gated cation channel 1 (Transmembrane protein 63C) (Q8CBX0)
Organism: Mus musculus (Mouse)
Function: Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P1W3}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27045885, ECO:0000269|PubMed:37945568}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at mitochondria-ER contact sites. {ECO:0000250|UniProtKB:Q9P1W3}.
Interaction partners:
- Inner centromere protein
- Aurora kinase B
Sequence:
MSAFPDSMDQKFHNMTVNECFQSRSTVLQGQPFGGIPTVLVLNIILWVFVVLLYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKSSPSEVSLEAERRDRGFSSWFFNSLTMRDRDLINKCGDDARIYITFQYHLIIFVLILCIPSLGIILPVNYIGTVLDWNSHFGRTTIVNVSTESKFLWLHSLFAFLYFLINLAFMGHHCLGFVPKKSLHFTRTLMITYVPTEIQDPEIISKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGKVMIKTHPCSRLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVQLKRLDLIFVTFQDARTVRRIYDDYKYIHCGRHPKQSSVTTIVKNYHWRVAHAPHPKDIIWKHLSIRRFSWWTRFIAINTFLFFLFFFLTTPAIIINTIDIYNVTRPIEKLQSPIVTQFFPSVLLWAFTVTMPLLVYLSAFLEAHWTRSSQNLIIVHKCYIFLVFMVVILPSMGLTSLHVFLRWLFDIYYLEHATIRFQCVFLPDNGAFFINYVITAALLGTGMELMRLGSLCTYCTRLFLSKSEPERVHIRKNQATDFQFGREYAWMLNVFSVVMAYSITCPIIVPFGLLYLCMKHITDRYNMYYSYAPTKLNAQIHMAAVYQAIFAPLLGLFWMLFFSILRVGSLHSITLFSMSSLIISVVIAFSGVFLGKLRIAQRYEQPEEETETVFDVEPSSTTSTPTSLLYVATVLQEPELNLTPASSPARHTYGTINSQPEEGEEESGLRGFARELDSAQFQEGLEMEGQSH
Protein: Elicitor-responsive protein 3 (OsERG3) (16 kDa phloem protein) (RPP16) (Q0JBH9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in plant defense signaling (Probable). Does not bind to phospholipids in a Ca(2+)-dependent manner in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21756975}. Note=Does not translocate to plasma membrane upon fungal elicitor or calcium treatment. {ECO:0000269|PubMed:21756975}.
Interaction partners:
Sequence:
MVQGTLEVLLVGAKGLENTDYLCNMDPYAVLKCRSQEQKSSVASGKGSDPEWNETFMFSVTHNATELIIKLMDSDSGTDDDFVGEATISLEAIYTEGSIPPTVYNVVKEEEYRGEIKVGLTFTPEDDRDRGLSEEDIGGWKQSS
Protein: Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] (Q9D8B7)
Organism: Mus musculus (Mouse)
Function: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11053409, ECO:0000269|PubMed:11739175, ECO:0000269|PubMed:16093349}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BX67}. Cell junction {ECO:0000269|PubMed:11053409, ECO:0000269|PubMed:16093349}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q9BX67}. Cell junction, tight junction {ECO:0000269|PubMed:11053409, ECO:0000269|PubMed:11739175}. Note=Detected in the acrosome region in developing spermatids (PubMed:28617811). In epithelial cells, it is expressed at desmosomes but not at tight junctions (By similarity). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (By similarity). {ECO:0000250|UniProtKB:Q9BX67, ECO:0000269|PubMed:28617811}.; SUBCELLULAR LOCATION: [Soluble form of JAM-C]: Secreted {ECO:0000250|UniProtKB:Q9BX67}.
Interaction partners:
- Integrin alpha-M
- Tight junction protein 1
- Junctional adhesion molecule B
- Integrin beta-2
- Partitioning defective 3 homolog
- Junctional adhesion molecule A
- Integrin beta-2-like protein
- Golgi reassembly-stacking protein 2
- Espin
- KICSTOR complex protein kaptin
Sequence:
MALSRRLRLRLYARLPDFFLLLLFRGCMIEAVNLKSSNRNPVVHEFESVELSCIITDSQTSDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRIWNVTRSDSAIYRCEVVALNDRKEVDEITIELIVQVKPVTPVCRIPAAVPVGKTATLQCQESEGYPRPHYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFNAVHKDDSGQYYCIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSKQDGESYKSPGKHDGVNYIRTSEEGDFRHKSSFVI
Protein: LD30628p (Loechrig isoform III) (SNF4/AMP-activated protein kinase gamma subunit, isoform G) (Q8I0A1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYRRRYSAFEPSTPRVGVLPSPPPQYANPPADTAAPKTPPKLSVHFDPNLPKDNDSNNNLTGSENANAKGGGRKARSLSNSPLYHRKKRYGHLPALMSNNGPTASSNYQLLNSANLRDLIDGQRHSHHVSRRDDSQSHSHSESPSHIGHISQSNQSIPSLPSLPSGKNKTKDGKKLKATLTAAMSSSLLRRKAHSNHSQQQKLQLQQQQQEQHQQQLQQQQLRSNNSKAIANAARHSLGHSPSAAAAAAAVQQTLVYERRRVSSAHSSPSPTSRHHSPVHQCMLMRRRSDYSVEQIEQWKRQQQLLPRSGRKISLPVADPFLEKVNLSDLEEDDSQIFVKFFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNGVRAAPLWDSEKQQFVGMLTITDFIKILQMYYKSPNASMEQLEEHKLDTWRSVLHNQVMPLVSIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKRILRFLFLYINELPKPAYMQKSLRELKIGTYNNIETADETTSIITALKKFVERRVSALPLVDSDGRLVDIYAKFDVINLAAEKTYNDLDVSLRKANEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRKVIGIISLSDILLYLVLRPSGEGVGGSESSLRASDPVLLRKVAEVEIPATAAAATTTTPPRSPSAGSGNRSLIEDIPEEETAPARSDDADSDNNKSASEDKANNNQHDQTTTAATANGDSNNSPVEVSFADEAQEEEAADQVERSNCDDDDQPALAEIERKNASMDDDEDDGMSSAVSAASALGQSLTPAAQEMALVSE
Protein: Autophagic-related protein 16.1 (Q19124)
Organism: Caenorhabditis elegans
Function: Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.2 to regulate autophagic processes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24185444}.
Interaction partners:
- Autophagy-related protein 18
- Autophagy-related protein 5
- Ubiquitin-like protein atg-12
- Ubiquitin-like-conjugating enzyme ATG3
- Autophagy-related protein 11 C-terminal domain-containing protein
- Ras-related protein Rab-33
- Autophagic-related protein 16.2
- Protein lgg-1
- Protein lgg-2
- Serine/threonine-protein kinase unc-51
Sequence:
MADSYRKLIIERLEDVKQRNKQTATLYNNYSKLAEQLEKKHKYGTSSSNSSQLETGELARVKEEMAELYRSKCQNDQRLIDANHRIADFEKKSSAIIAEKIALEATAKSICAKYAKTEVELQRLKVDNDQLNDERIASNTTVTMLTKQIQDIENDRIHFLNKIRELNEQRVDFLNAEVALEEKRRNSRIQDMITSAVQDITDKDTKLEEMLRAMPDTNSNGDLLLGDSVPSRAEFVLECEEGEVNDVHWLDGETFATGGSDRNIKIWKVDGHGGYTRIGTLAGSNAAFTRIDYERDRKHFIASSNDKNVRIWNLDNSRLLSTLSGHSDQVTCVKFYQSHSAVSGSADRVIKIWDIQNQRCSRSLFPASKVLDVATNMGASPSLFASGHFDKKLRFYDGRSTDPVRTVDMGGRITSLDVTMSGCELLVSTRDDTISLIDLRTFQTVHCYSAENYRTSSDLSRVVLSSGNEYVAAGSSNGSIFVWNRNSTKLEKQLCSNSENAIFSLSWNPTGYGLLSSSKQKFVTLWK
Protein: Branched-chain-amino-acid aminotransferase, cytosolic (BCAT) (EC 2.6.1.42) (ECA39 protein) (P54688)
Organism: Caenorhabditis elegans
Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Subcellular location: Cytoplasm.
Interaction partners:
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Putative cystathionine gamma-lyase 2
- cystathionine gamma-lyase
- Putative folylpolyglutamate synthase
- hydroxymethylglutaryl-CoA lyase
- Branched-chain-amino-acid aminotransferase
- 2-oxoisovalerate dehydrogenase subunit alpha
- GCS light chain
Sequence:
MPAILSRVAPRTFNLVGSRLMASAARLETVPREEIHKEYDRKKTFYHRDLEIQLAGPTQLKTKPLDPTKLKFGHTYADYMMTCDWDAERGWHHPKIEPIGELKIHPGAKVLHYASELFEGMKAYRGIDNKIRMFRPEMNMARMKRTALRAALPDFDSEEMINVLTELLRLDQEWVPNSDVCSLYLRPTLIGTDPTLGVGCATEAKMFVITGPVGAYYSTGFQPVSLLADSRFIRAFPGGVGAYKMGCNYAPTIWVGKEAASKNCQQVLWLYGENEDLTEVGTMNIFLFWKNEEGDMELITPPLHRGLILPGVTRDSLLELGREWGEYKVTERTLNMEEVKKALSEKRLYEMFGSGTACVVSPVGKILYHNKVTDEYEELHIPTMSSKFGVMQKFYNTINDIQYGRIIKDGWMRDI
Protein: Caspase-activated DNase (Q9NDR2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MISYIRDAIMSPTTRSSSNNKKSNQPTGEVLKDVSSSESRGTAGAPMRGYKVTDNERTRKYGIGANSLEMLIAKAKSKFPLLELHLYLASDGFEVSDDEYLKSLPAQTLFIVSGPDAVITTDADFEFEKMRQQSPLLKVADIFYDFIEQHPEKFRRMITEYEHQKQRRVLDNSKTHLSLKAEHVEWFTGGEERFHSKEEAMATRAQTRVRGYYYKAKEELTRNPLYRQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHEFLKQHLGDEETDAGRIPSKRLRQVIREYTKENCILDEWSTSLCSDLGDFYCQGSYSENGNSCSKQHTINPYASRENLILFQVWNLDHQIELCRTILPALVANVEELVSHPQTKCSIHKKQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSNRSNGRLLCSDCHEYRIVQELMEVQVDSLAT
Protein: Protein kinase-containing Z-DNA-binding domains (Z-DNA binding protein kinase) (Q5NE14)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Interferon-induced GTP-binding protein MxB
- Interferon-induced GTP-binding protein MxC
- Interferon-induced GTP-binding protein MxE
- Interferon-induced with helicase C domain 1.
- Interferon-induced GTP-binding protein MxA
- Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog
- Interferon phi 3.
- ISG15 ubiquitin-like modifier
Sequence:
MAKMSAENEIEMRICDYLRRHGRSTVQDIFKELKLEKSTVNRHLYSLQASKQVFKTVEDNKRPVWNLVESMNDEQKAKPEQIKPEMTRDAIEEKHVKDLLKSGGLKASHIASKLGQQTQSTNKLLYGLMEKGEVRKCSKSHMWTLKNDQERNGSGSDRKLTSVSGMSQTFDVIEELGDGGYGFVCKVKHKIDDKIYAVKRVEFNSEAEPEVKALARLDHPNIVRYFTCWPDSDNWMSNQETNEKSNTTGSSTDTDDTNERSASDDDVADDEDDDDDDVSDDVTLGMESLTFTESTSAAKASGQCDPTNHRTYLFIQMEFCEGGTLTSWIGERNYGGKQRIPLEIHRIFYEISSGVEYIHSNNLIHRDLKPDNILFNDGKVKIGDFGLVAAQKNPSGDPIERSKRKGTPTYMSPEQENLRNYDEKTDIFPLGLMWFEMLWKISSGMERAEIWTNLRNQKLPDQFCERYTAENKFIEKMLSVTPEDRPHAKDIRLNLETFFSLHQNSLSQKTI
Protein: Brevinin-1JDc (B3A0N0)
Organism: Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)
Function: Has antibacterial activity against E.coli ATCC 25992 (MIC=49 uM), E.coli CIB 84492 (MIC=25 uM), S.aureus ATCC 25923 (MIC=6 uM) and S.aureus CIB 85462 (MIC=3 uM).
Subcellular location: Secreted {ECO:0000305|PubMed:22917879}.
Interaction partners:
Sequence:
FLPAVLRVAAKVVPTVFCLISKKC