wanglab/gogpt-training-data huggingface dataset:
Protein: Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) (Q8N697)
Organism: Homo sapiens (Human)
Function: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5. Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity).
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:32433612}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:32433612}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91W98}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- TLR adapter interacting with SLC15A4 on the lysosome
Sequence:
MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA
Protein: Fibronectin type III domain-containing protein 8 (Q8TC99)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASEALHQVGDGEEAVLKKENFNMMNALDQLPKPFSNPKSMNRTVTTKGLPLASKGNLVNFLEDDTINLLKPLPVEDSDCSSDETSISAFSSTLLNPIKLAVTQPNSSFFAGMLEGELNKLSFSPMAKNAENEDLALGPCPCPSKSQMATRGLLDLDNPELETETSSTHSESSVVVDLPDTPFIFEHTVNNSTAVISWTYALGKQPVSFYQLLLQEVAKTQENELPEAKNRPWIFNKILGTTVKLMELKPNTCYCLSVRAANTAGVGKWCKPYKFATLATDFSSFPENYPIQITVRRKEPRQKIVSIGPEEMRRLEDLEYLFPC
Protein: Exosome complex protein LRP1 (Like an rRNA processing protein 1) (Yeast C1D domain-containing protein) (rRNA processing protein 47) (P38801)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. Required for activity of RRP6 in 7S pre-rRNA processing. Also has a role in 3'-processing of U4 and U5 small nuclear RNAs (snRNAs). Acts as a mRNA export factor. Mediates mRNA degradation upon UV irradiation. Maintains genome integrity where it is involved in both non-homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks. During NHEJ, required for joining 3'-overhanging ends. Also involved in telomere length regulation and maintenance.
Subcellular location: Nucleus {ECO:0000269|PubMed:11914276, ECO:0000269|PubMed:12972615, ECO:0000269|PubMed:15489286}.
Interaction partners:
- Exosome complex exonuclease DIS3
- Exosome complex exonuclease RRP6
- Exosome complex component CSL4
- Exosome complex component RRP4
- ATP-dependent RNA helicase DOB1
- Exosome complex component RRP46
- M-phase phosphoprotein 6 homolog
- Exosome complex component RRP45
- Exosome complex component RRP43
- Exosome complex component RRP40
Sequence:
MEDIEKIKPYVRSFSKALDELKPEIEKLTSKSLDEQLLLLSDERAKLELINRYAYVLSSLMFANMKVLGVKDMSPILGELKRVKSYMDKAKQYDNRITKSNEKSQAEQEKAKNIISNVLDGNKNQFEPSISRSNFQGKHTKFENDELAESTTTKIIDSTDHIRKASSKKSKRLDKVGKKKGGKK
Protein: Oxaloacetate tautomerase fahd-1, mitochondrial (EC 5.3.2.2) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (P34673)
Organism: Caenorhabditis elegans
Function: May have hydrolase activity.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:26266933}.
Interaction partners:
- Fumarylacetoacetase
- Homogentisate 1,2-dioxygenase
- Probable fumarate hydratase, mitochondrial
- Aromatic-L-amino-acid decarboxylase
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- hydroxymethylglutaryl-CoA lyase
- ShKT domain-containing protein
- Succinate dehydrogenase cytochrome b560 subunit
Sequence:
MSSLAGFRNLATKIVCVGRNYKDHALELGNAIPKKPMLFVKTVNSFIVEGEPIVAPPGCQNLHQEVELGVVISKKASRISKSDAMDYIGGYTVALDMTARDFQDEAKKAGAPWFLAKSFDGSCPIGGFLPVSDIPNPHDVELFCKINGKDQQRCRTDVMIFDIPTLLEYTTQFFTLEVGDVVLTGTPAGVTKINSGDVIEFGLTDKLNSKFNVQ
Protein: ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15) (Q91ZF1)
Organism: Rattus norvegicus (Rat)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11804844}.
Interaction partners:
- Inward rectifier potassium channel 16
Sequence:
MVARWVKGSEDAPLALQKIPDLQSGPRSLRMEAIHIGMSSAPLVKHSNGVGLKAHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVVYYAIAFIHGDLELGESNSNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVISKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQKLEEQYRQEDQRERELRSLLLQQSNV
Protein: Myb-binding protein 1A (Q9BQG0)
Organism: Homo sapiens (Human)
Function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}.
Interaction partners:
- KRR1 small subunit processome component homolog
- HEAT repeat-containing protein 1
- Trifunctional purine biosynthetic protein adenosine-3
- Nucleolar protein 6
- DNA-directed RNA polymerase I subunit RPA1
- Nucleolar RNA helicase 2
- Protein RRP5 homolog
- Pescadillo homolog
- DNA-directed RNA polymerase I subunit RPA2
- Tyrosine-protein kinase BAZ1B
Sequence:
MESRDPAQPMSPGEATQSGARPADRYGLLKHSREFLDFFWDIAKPEQETRLAATEKLLEYLRGRPKGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQSFEDLPLCSILQQIQEKYDLHQVKKAMLRPALFANLFGVLALFQSGRLVKDQEALMKSVKLLQALAQYQNHLQEQPRKALVDILSEVSKATLQEILPEVLKADLNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKDRKLPAIALDLLRLALKEDKFPRFWKEVVEQGLLKMQFWPASYLCFRLLGAALPLLTKEQLHLVMQGDVIRHYGEHVCTAKLPKQFKFAPEMDDYVGTFLEGCQDDPERQLAVLVAFSSVTNQGLPVTPTFWRVVRFLSPPALQGYVAWLRAMFLQPDLDSLVDFSTNNQKKAQDSSLHMPERAVFRLRKWIIFRLVSIVDSLHLEMEEALTEQVARFCLFHSFFVTKKPTSQIPETKHPFSFPLENQAREAVSSAFFSLLQTLSTQFKQAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDENDRVVVTDDSDERRLKGAEDKSEEGEDNRSSESEEESEGEESEEEERDGDVDQGFREQLMTVLQAGKALGGEDSENEEELGDEAMMALDQSLASLFAEQKLRIQARRDEKNKLQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP
Protein: Nucleosome assembly protein 1-like 1-A (xNAP1L-A) (Nucleosome assembly protein 1) (NAP-1) (NAP1) (xNAP-1) (xNAP1) (Q4U0Y4)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as a chaperone for the linker histone to facilitate deposition of histone B4 onto linker DNA. Required for both remodeling of sperm chromatin into nucleosomes, and linker histone binding to nucleosome core dimers. Plays a role in tissue-specific gene regulation. Required for primitive hemopoiesis, acting upstream of tal1/scl.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14550533}. Nucleus {ECO:0000269|PubMed:14550533}. Note=Cytoplasmic prior to the midblastula transition, becoming predominantly nuclear subsequently. {ECO:0000269|PubMed:14550533}.
Interaction partners:
Sequence:
MANIDNKGQTELDQQDMEDVEDVEEEETGEDANSKARQLTAQMMQNPQVLAALQERLDDLVGTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHELERKYAALYQPLFDKRSDIINATYEPTEEECEWKVEEEDISGDLKEKAKLEEEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMLQEHDEPILKHLKDIKVKFSDAGQPMSFTLEFYFEPNEFFTNEVLTKTYKMRSEPDESDPFSFDGPEIMGCTGCLIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVPNDSFFNFFTPPEVPENGELDDDAEAILTADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADDEEGEEEADEDNDPDYEPKKGQNPAECKQQ
Protein: DNA damage-responsive transcriptional repressor RPH1 (P39956)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional repressor of photolyase PHR1. Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1. Derepresses PHR1 transcription when phosphorylated.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:14562095}.
Interaction partners:
- JmjC domain-containing histone demethylation protein 1
- Histone H3
- Protein ECM5
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Transcriptional activator/repressor GIS1
- Serine/threonine-protein kinase RIM15
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Histone demethylase JHD2 demethylase JHD2)
- Histone H4
- Serine/threonine-protein kinase RAD53
Sequence:
MTKLIAPSEIVGGVPVFKPTYEQFEDFYAYCKAINKYGMKSGVVKVIPPKEWKDKLDLPYSAETLQKIKIKSPIQQHISGNKGLFMVQNVEKNKTYNIIQWKDLSKDYVPPEDPKARRNSRKGSVSKSTKLKLKNFESSFNIDDFEQFRTEYTIDLSDFQNTERLKFLEEYYWKTLNFTTPMYGADTPGSIFPEGLNVWNVAKLPNILDHMETKVPGVNDSYLYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKFYKFMQEQFPEEAKNCPEFLRHKMFLASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLAESVNFALEEWLPIGKKAGKCHCISDSVEIDVKKLAKSWRDNNKESKGTPPLNQLPNPAMPLLHRPTLKEMESSSLRSTSPDVGHFSNFKSKSSGVSSPLLSRMKDYSNIVEPTLEDPTLKLKRISSFQEQPLNKLLKRETSQTAMLTDHEDNIVAMSLTSMANSAASSPRLPLSRLNSSNELSNAQPLLDMTNNTLAFPRPNGPSGLNPLLYISNKNISGISHSAPHSPVNPNISLIKRVKSPNIVTLNISRESSRSPIALNYEARQQHSQQHSFSTPSTVSNLSTSVLGPLSDTNDIKTPHPERPNHKTANRILKKESPVETSKSNLILSKVASTRQEDSFTSRNDDLDKEQGSSPLNSKFAPEEIVLSGKNKIYICKECQRKFSSGHHLTRHKKSVHSGEKPHSCPKCGKRFKRRDHVLQHLNKKIPCISNETTVDAPIMNPTVQPQDGKAAINQQSTPLN
Protein: SET domain-containing protein (Q38DZ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone H3 variant
- Histone H3, putative
- Uncharacterized protein
- Histone H4
- Histone H4
- Polyubiquitin, putative
- Histone H2A
- Histone H2A
Sequence:
MVMKANFCFKIGEVICPIPTNYTFGNGELVLDDERRVALGEEFNATIINNFLIATQEINKDEFVVVNPCLVIYDGARLPQGSAASTFKNAREDEQQRLFPYADEKVRQQALADGFIATCCQKSVEIVRKPDSGFATLATCSHEAGSIVFTSTALLLPFPAQGTIELPGKKYLRPSCCVEFVRHSCQPNVQLEISGTTISAVATRAIEKEEQLTRNFLCTEWDIAHPFSCACKTTSCYGIIRGFRHLGSEQQAQLLPSVCAAIKERHSAVVPPTASLAGLQKSTVLTLTSDGKIATQQFVPPGTVLLQVDRFDIRPHRVVIDSLSIAHSCDANTVLLDGRLVSLRMLQPGDQLSLNLSTLQYELPAPFECKCGSPKCSNTVRGFRGLSDEEKKQLLPFTQQPVFLEALQNGCPWSSSNSLAVTRRHPTMGEITYAGDFIPKGTQVFDLRGVVLPFATKHTIFVGDDEHLFLTDQARCIAHSCEPNLRVVMDRSTKSGYCLSLRDIKLDEMLTYDYLTTEWELASSFRCICGTANCYGLIRGFRYLDARAQLRLWPHAARGVKSMFSRQRRGVLASLDDSLISIHETSGELRLMCDTTSGVKLFNVTDVQVIGDEVALDDIRVKHSCFANAVLLGRSVVLRRASLRGEAVTININHLCYTTTSFKCNCKGEHCVGEVSGFKGLTDEMKNAELICASPHVREAAVLDGFLVKSSSPLVEVKADVQMGQSTFAKSDIKKGTRFFRVNGLTLPFPTMHTILLSNRRHLLFGGGAQCLAHSCDPNTRVLTDNTARTIECIALRDIRKGEVISFNYLTTEWDMQYPFMCVCGSQKCYGWIGGFKHLGNDARQKLWNVTSTAIKSLVADTQSNPKGAWIQIASKRLMVCDEGTVHVATEMVAGTVVIEYSAVEVLDNFVYIDGVRLKHHCSPTAALIEKRVVLLRTVSAGDELNVNLNCLSYSLPEEIECKCCRFAQPHKVRGFKWLDEQDKEALIVFAQPDVRAAAIRDGFTSRSDSQLIGLRSCTAGLEVIAKTRVAAGTRLLATKGRSLPFPTPLTLQLGERRHLLPSGGAQFVSHSCDPNTCIRVDALNEAIEFETIRDIAVGEVVTANFVTTEWELHSPFQCKCNSSSCLHNIRGFKFLSSAQRSMLQRYITPAMRRLAGLTASVRLPPVLDVNQSRMLYAVSPVARKTVLLECTNIDIQPVQVAVGENGYIIQHKEEGNTVLVEGRFLALRSIEAGELLTVNMNYFVYDMKPLFPRAYSQHCLGFCHMEEDTKQQNLYLCEPPVRAQAMRDGWTVKSTSPLIEIRQNGDMGQTAYASTFIKKGVVLFDVSGFVVPFPTMYTICVGESRHLLFGEGAECIAHHCDPNVQVEVNEQKTRLRFVTLREISKGEMVTFNYCTTEWVMNSPFVCLCGSSYCAGTIRGFSSLCEADQQRLWPITSYVVKRLLARDGE
Protein: Nuclease HARBI1-like protein (F4K1D8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MERDTSRKANMEMSSFAWGYATWIFIYVLSGWEGSAHDSRVLSDALRKFYLVDCGFANRLNFLAPFRGVRYHLQEFAGQRRDPETPHELFNLRHVSLRNVIERIFGIFKSRFAIFKSAPPFSYKKQAGLVLTCAALHNFLRKECRSDEADFPDEVGNEGDVVNNEGNAMNTNEIDNEEPLEAQKQDRENTNMWRKSMAEDMWKDATNLEIH
Protein: Dynamin (EC 3.6.5.5) (Protein shibire) (dDyn) (P27619)
Organism: Drosophila melanogaster (Fruit fly)
Function: Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Interaction partners:
- Amphiphysin
- Dynamin associated protein 160, isoform D
- Endophilin-A
- Cortactin, isoform A
- Clathrin heavy chain
- phosphoinositide 5-phosphatase
- Mitochondrial fission 1 protein
- Protein nervous wreck
- Calmodulin-related protein 97A
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
Sequence:
MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSGLDNPRLSPPSPGGVRGKPGPPAQSSLGGRNPPLPPSTGRPAPAIPNRPGGGAPPLPGGRPGGSLPPPMLPSRVSGAVGGAIVQQSGANRYVPESMRGQVNQAVGQAAINELSNAFSSRFK
Protein: Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (Suppressor of RNA polymerase B 4) (P32569)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16630888}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 14
- DNA-directed RNA polymerase II subunit RPB7
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 9
Sequence:
MTTEDPDSNHLSSETGIKLALDPNLITLALSSNPNSSLHSPTSDEPVPESAGKADTSIRLEGDELENKTKKDNDKNLKFLKNKDSLVSNPHEIYGSMPLEQLIPIILRQRGPGFKFVDLNEKELQNEIKQLGSDSSDGHNSEKKDTDGADENVQIGEDFMEVDYEDKDNPVDSRNETDHKTNENGETDDNIETVMTQEQFVKRRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSMSPFLRKVVKPSSLNSDKIPYVAPTKKEYIELDILNKGWKLQSLNESKDLLRASFNKLSSILQNEHDYWNKIMQSISNKDVIFKIRDRTSGQKLLAIKYGYEDSGSTYKHDRGIANIRNNIESQNLDLIPHSSSVFKGTDFVHSVKKFLRVRIFTKIESEDDYILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELMYQIKKECALLISYGVSIENENKVIIELPNEKFEIELLSLDDDSIVNHEQDLPKINDKRANLMLVMLRLLLVVIFKKTLRSRISSPHGLINLNVDDDILIIRPILGKVRFANYKLLLKKIIKDYVLDIVPGSSITETEVEREQPQENKNIDDENITKLNKEIRAFDKLLNIPRRELKINLPLTEHKSPNLSLMLESPNYCNALIHIKFSAGTEANAVSFDTTFSDFKEVEDFLHFIVAEYIQQKKV
Protein: Probable ABC transporter permease protein YphD (P77315)
Organism: Escherichia coli (strain K12)
Function: Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ribose import binding protein RbsB
- Uncharacterized ABC transporter ATP-binding protein YphE
- D-allose-binding periplasmic protein
- ABC transporter periplasmic-binding protein YphF
- Galactose/methyl galactoside import ATP-binding protein MglA
- Ribose import ATP-binding protein RbsA
- Arabinose import ATP-binding protein AraG
- Xylose import ATP-binding protein XylG
- D-allose import ATP-binding protein AlsA
- Galactofuranose transporter ATP-binding protein YtfR
Sequence:
MSASSLPLPQGKSVSLKQFVSRHINEIGLLVVIAILYLVFSLNAPGFISLNNQMNVLRDAATIGIAAWAMTLIIISGEIDVSVGPMVAFVSVCLAFLLQFEVPLAVACLLVLLLGALMGTLAGVLRGVFNVPSFVATLGLWSALRGMGLFMTNALPVPIDENEVLDWLGGQFLGVPVSALIMIVLFALFVFISRKTAFGRSVFAVGGNATAAQLCGINVRRVRILIFTLSGLLAAVTGILLAARLGSGNAGAANGLEFDVIAAVVVGGTALSGGRGSLFGTLLGVLVITLIGNGLVLLGINSFFQQVVRGVIIVVAVLANILLTQRSSKAKR
Protein: ATP synthase epsilon chain, chloroplastic (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit) (P09468)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00530}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00530}.
Interaction partners:
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit beta, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit alpha
- ATP synthase subunit c, chloroplastic
- ATP synthase subunit alpha
- ATP synthase subunit delta, chloroplastic
- ATP synthase subunit 9
Sequence:
MTLNLCVLTPNRIVWDSEVKEIILSTNSGQIGVLANHAPIATAVDIGILKIRLANQWLTMALMGGFARIGNNEITILVNDAEKNSDIDPQEAQQTLEIAEANLRKAEGKRQTIEANLALRRARTRVEALNTI
Protein: Putative mediator of RNA polymerase II transcription subunit 23 (Putative mediator complex subunit 23) (Q55BN0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Putative mediator of RNA polymerase II transcription subunit 18
- Putative mediator of RNA polymerase II transcription subunit 14
- Putative mediator of RNA polymerase II transcription subunit 6
- Putative mediator of RNA polymerase II transcription subunit 31
- Putative mediator of RNA polymerase II transcription subunit 22
- Putative mediator of RNA polymerase II transcription subunit 21
- Putative mediator of RNA polymerase II transcription subunit 7
- Probable cyclin-dependent kinase 8
- Cyclin-C
- UbiA prenyltransferase domain-containing protein 1
Sequence:
MYTNIPQQQQNIPQQQQQNIPQQQNVQNIQQPLPHTNIQQQNIQQQQQQYQLQFQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQQQRPQTPQQNAQQQSQQSQQSQQQQASLGQGQQGSGPNTPPQSQPETIESIFKQLDLNSTGQQAKDILEQCKLKIHSLESQQLIAQAKYKLFSLAANYQSTVFQHIKMVSTTTTPTSTPTTSTTNTPQNSNTSSSSSTGTSSSTIGSSSSSTTTSTTNNENLGLPISKEIYQQKIQLWISIITFLRENLQYFGKWRESIYISIQNITQSTLLPTLIQKEFFTELFILLKSIFSFVNIEFPHYIALKEVKLSNTHQCLEYQNLIEPYYCRAAKLSSLLSLSSLSSSARIVGSSILLNQDAMIGYTNQLTESPPFFTSNRLLNNKYSTIVHHLLSQSASIEPIKELLFPQVQSNTLKSKIISIITEATISKTMQLLNKYPNQIIENQIENNSWKEWLLFSEQFYFLCENGLVDLEQFIVTLSEKRMNNGDPIKDNMVVLLISKTIIIQDVKTLFKQHLQNVNSNHYGHLIPLVLSFVNNDSNYPIISQNISLYFFLMRINTNTENPEIIAHIKKLLDNFNFQFTLFQQYRNWWESEKVKQKPEFFTTIQDITYFSIICNVIPTEGEMELIRFQSNGSDQSIQFPGVGGIGTVVTGKIKPVSNLILLNLSLRCRRKLIQESVLLLLDKEVPISPGFLEDYCRTVHYTPGPVSPFLFSYFKKFHRLAPIHAVIESVSHRLLKVLKSNKELAVLLRALQDIQTQKPIQNIQLSRSIDYLLLKASISLPVDLISAKEIWKSLDLGLFNNRRLITSIARLIKLKGIQDFNRISDVPVFIENCFKSNPYCFSKSTLEFFPDILKNEFKKNSENLSLNPNQFTNLTLMKPPTLQKVQLENQQRFQLFSVGGKLQILQKQALVQQYLTDNNSNLLLCQVFIYMLENKIKMDVMGPLIQQMFFKQIIGNQQPQQQQQPQQPPPLAISNQQLNRITSVFIDFIFDEVYVNHPLKQENLHQHVSEFLCQSIFTYKILTLNSVLLALLDRDDHPSMPTILDTFLFSSAEIQNRLQFFSTYPSDFFISQSFRNDDNYFIKNCEFNNRFNDLIPTVIDPNTLIEQSTQDTILPIYYSNSISRLMPIVEIIISKSIELNNGDLFEKTINHFNIPYHYYQDEKETTIKDTLIYYYDSQLFKLNPELKLLFLKLLNQSDIDNRFSNIFNQFLKSSRIEDITMVGSTAYFNDLISPLAEMMDLTNQNVFDTFSFKTENTFSSIDISNPLELKLNNIILEILLLPLDSNWIANGLVSLLNYSNRNKNFSDRKIDPPSSSMVLALSIIFSILPTQIHNSFIPIVTQNLSNELNFSKFKSPIMKNQYNFGNYTTNVEEKMTEPIEWYIYFIQFYYLYCPLERLLSLNDLVTNIRPLIKNVYQYYVLLTIVSPVLLRFGTQTNHLIQITREMLQILTDSYLSSYIENTLQDLESCWIGNTNDDDDIMDTTNFNLFGKRIGYDDDDDDEDDDYYDEDDEDEDDDNEDDQQDENDRMDFSQDTNNIFNRSMGDHDHLMMMSNSENLNDPWSDKNEFFRKQKSIFLKIDSQLIDTIIDWIYHIKMIFPFQPFRDELLRIVKEFKPNFLSKFNQLN