Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F1QJB6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365027}.
Interaction partners:
- Checkpoint kinase 2.
- Cellular tumor antigen p53
- ATR serine/threonine kinase
- Nibrin
- Serine/threonine-protein kinase CHK1
- Double-strand break repair protein
- RAD50 homolog, double strand break repair protein.
- Mediator of DNA damage checkpoint 1.
- Tumor protein p53-binding protein, 1.
- DNA helicase
Sequence:
MSLALHELLVCCRGLENEKATERKKEVDRFRRLICSPDTVEELDRTSGSKGSKQLTWDAVFRFLQKFLKKETELLQSGKANVSASTQANRQKKMQEISSLMKFFIRCANQRGPRLKCAELISHVVEVLQSPFSCVAYGEDYSSILLKNILSVRKYWCEMSQQQWHSLLDLFCGLFNRGTRSINRVQVSRIIYTVVWGCCVQTEGLSHTLFNFFLKALSNSRAEKQLMVLENLVSAVNVFLRSVLLSCRKRVCGLGEEVLSDMLCVYTGMRPSSVLKEELVKFFQIQLFVHHPKGAKTIETGAQAQDWVKWRSQLCTLYDALVSEISQIGSRGKYATGSRHIAVKENLIELTADVCHQLFNQSTRVQEVTSSVCRDTQRDSPQSCKRRRVELSNWELIRSKLQPHHSDFDMIPWLQVTAALISKYPSILLTDDVVPLLGLLCQLQGEQQRRGERAPYVLRCLKELALCHAKSSANSSACTAELGRLWARVWVLALRGVSSAQTGSLCLELLRIMVQESLVPVDREFWKVFSGAVCKPSLVSALSLTQALLKCSVPKSVHSRDATSVVLTDAGGEPPSLRDSIISWLIMNEQNEETEENCRPHLIISRDFPLYLIPRIVVSLTLKDSRAGLTFLMGSLKPDCFSPENSSLTETKATMDEVESLFLQFSFDEAHSSAGFTVDKDSVYSEKPQFTVIQALRSKLEHSLLSIAEQLFTCYSPDSTNTPHECVLRCVSLLIGVLAAYVCIGMLSEEQACLSPLFLKAKALVHEFSHYTSTAKSKLAENETLASVQSVMLLCSDCICRREKGDKMSTISRTLFMKTLPVRLLNDLCDMSKQLLSNSGKKDTIVIESEPVDMQTSRIQVDNQEEIDLFEDGDGTQHITSRPSQSNEEAADSKFITGTKSALSEEHLSKQDLTFLSVLGFLSLCASSELNGGFSFKPLDTQRKLLKLLDLADFSQMLHLQMYLSLLKKLPAEVASLDPEEFNALLRPLADVCSLYRQDQEVCSAILFSLLPSIRCLGLSSSGSEQEEDMADIKGSLLKVISGFCFLGKSGKCTSSVRVALRQCLLALLEADPCCKWAVLTLREEELPVSAVLSSLLADSHQHVCMLTALSVESLFLKKALHSSRKMMLPLKNQQTAFENIYLKAQEGIRRQKNCPSEDLPDETFNRRATLLKSVSMVMSCSPVCEKQALFALFQSYKENGIDEQLIKKVLRGISKSLGNRDHKSLINSHLYYLVAEWLNQKQSDSSYTLQSFPYALLDCCSLEEFFRSSYHVLIPHLVFLNDFEGVKSIGDHLGQDWKQLLAKCFPKIMVNILPHFALAGQDTHVAQQREKAHRVYDILKNSNCLGKQQIDSLICNNLPDIVVELLMTLHETAGDKGDLQKFTGELDPAPNPPFFSSYVIKATLDYLSKCHSANHKSLVAILSKTPMSIQRILVAVCQKADETTNAYERHRILMMYHLFVSLLLKEVKDGLGGAWAFVLRDIIYTLIHHINSRSSQQDEVSTRSLSLCCDLLSLVCQTAVEYCDDALESHLQVIVGTLTAQVTEQSAISEQVLSLLRFLVMENPENRMLRKSIPLLEPFPEQPNFAELRAAQHALKYSSGAFTLRQEIEHFLSVASCDSLPLARLEGLKDLKRQLHSHKQQIGQLLKECHADLDSCILVNLVLNLLQLCKIAANHPGGGDIMKAAGRCLGELGPVDLSSIALHHGKDQLYARAAKLFHNVPHQWIFIILNSMDNALTNHSIAVRQTAGLCIKDILATQSGIEFGEIHKSKRDPLLAYLNPFRSSKKREPIMAMDVTPESRDRLTSADLWLMQPDGHKDWLKNLCMALLDSGGVRNEALLLTRPLCEVKTDFCQRMLPLFVHDILLGDVDGSWRQLLSTHIQSFFSQCRRPSTPTSRPTTPMLSDSGNTTDAANQCQIDKASLRSMLAVIDHLRQQSRPLAPGSNEYGTVCDSNFWLDLNYLEVAGAAQMCSAHFTALLYSEIYVDKIRSNMEQNRRSQSRASRRITFEDNSQTLSVSNLNERSLEDSGFSLQDLLIEVYRCIGEPDSLYGCGGGKLTSPLTRIRTYEHEAMWEKALVSYDLHSNLPEVTRQIGIVEGLQNFGLCSILSTYLHGLEKDGMEWGPELRELRFQAAWRSTQWDCDLPERNEKLKPGINESLFNALQALRDKEFSLFEQTLNYARGREVEELCRGSLEAVSSLYPALCNLQRISELQSVEELFSRPVTDSSLNEVYRKWQQHSDLLTDSDFSLVEPVLALRSSIQEALISSETDPDRKNYLISTYSSHLMELCRLARSAGNTQLAERAVFHMKQHNLVMSGSGSSSWAWQLEEAQVFWVKKEHGLALELLKQMIHKLDDLVCVNPAVVPVYSECLRLCGSWLAESCLESPAVILENYLERAVEVIEEHCGGLKSKLQSQKTQAYFSLARFSDAQYQGIENYMKSSEFENKHALLEKAKEEVDLMRERKVNNNRYTVKVQRELELDVKALANLQADRNRFLLKAVENYIECLELGEEHDTWVFRLASLWLENADVKAVNDKMKSGVKKIPSYKFLPLMYQLAARMGTKVSSSMASQDVGFHHVLNELICQSSVDHPHHTLFIILALVNANKDDSFSRSRSSKSSARQPSPLDLERAEVARKIIDVVRKKRAKMVKDIEMLCNAYITLAYMDASRHKTEKKAIPIPAEQPLMQIKDLEDVIIPTMDIKVDPSGRYEDVVTVRSFKRHFHLAGGVNLPKIIDCEGSDGISRRQLVKGQDDLRQDAVMQQVFHMCSTLLQRNAETRKRKLNIRRYKVVPFSQRSGVLEWCSGTVPIGEFLVDPQKGAHKRFRPQDWANMLCRKKMMEAQRMEFNDKLQAFTEVCQNFRPVFRYFCMERFLDPAIWLERRLAYTRSVATSSIVGYIVGLGDRHIQNILIDEQTSELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKAFYLQQHDEQAELNATLNPTPGGDEIETHRKASDSQSFNKVAERVLLRLQEKLKGVEDGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWQAWV