wanglab/gogpt-training-data huggingface dataset:
Protein: Radical SAM core domain-containing protein (G5EAS9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Molybdopterin synthase catalytic subunit
- GTP cyclohydrolase 1
- GTP cyclohydrolase II
- MOSC domain-containing protein
- molybdopterin adenylyltransferase
- MoaB/Mog domain-containing protein
- Adenylate cyclase
- Nucleoside diphosphate kinase
- Pyruvate kinase
- Uncharacterized protein
Sequence:
MTEPMLFKRGAAQATSSFSRFPRIHTRTRLPTWRRLSPSPSRYVTTGLNPQVEVQDEPTRSPSPTPTSSTRWNALKTAKPFSAFLTDTFNRQHDYLRISVTERCNLRCLYCMPEEGVPLSPPAHVLTSPEIVYLSSLFVSQGVTKIRLTGGEPTVRKDIVPLMQSIGELRHHGLRELCLTTNGISLHRKLEPMVEAGLTGVNLSLDTLDPFQFQIMTRRKGFDAVMKSIDRIQELNKMGAGIKLKINCVVMRGLNEREIIPFVEMGRDSPIEVRFIEYMPFDGNKWSKGKMVSYQEMLALIREKYPTLEKVVDHKNDTSKTYRIPGFQGRVGFITSMTHNFCGTCNRLRITCDGNLKVCLFGNSEVSLRDIIRQQNNGEPIDETALQELGLLEAARTAARVHDEGGVVSQRERELLDVIGMAVKRKKAKHAGMGELENMKNRPMILIDKTSDAQRNIRYFASMSSMMSKGQVMNVSTHSLGLGMPMATQVRLYHRERTTTSCEEPSNKDSKFASLPTSDDPDLPHLNRSQNVHMTLIDEKPISKRLATATCHVRFSNRRPWELLRQGPGSRKGDVFGIARIAGITAAKKTPDIVPLCHPGLGLTGVEVDVKLLDPSADDAEMKHGAMHVTATVGCVGRTGVEMEAMTATMGAALTVYDMLKAVDKGMVIGGVKLLEKMGGKSGHWVREENVKDE
Protein: Proteasome component ECM29 (Extracellular mutant protein 29) (P38737)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stabilizes the proteasome holoenzyme, probably by tethering the 20S proteolytic core particle and the 19S regulatory particle. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 26S proteasome regulatory subunit 6A
- Ubiquitin carboxyl-terminal hydrolase RPN11
- Proteasome activator BLM10
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit RPN10
- 26S proteasome regulatory subunit RPN5
- Ubiquitin carboxyl-terminal hydrolase 6
- 26S proteasome subunit RPT4
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit RPN12
Sequence:
MSISSDEAKEKQLVEKAELRLAIADSPQKFETNLQTFLPPLLLKLASPHASVRTAVFSALKNLISRINTLPQVQLPVRALIVQAKEPNLAAQQDSTNVRLYSLLLASKGIDRLSLQDRQQLLPLVVSNISCLTGTVAARMFHILLKLILEWVAPQESSHEQEEFVQFLQLDNDGFSFLMRQFTRFFLLVPSKQVQVSQQPLSRGYTCPGLSLTDVAFFTYDAGVTFNKEQLNKFKKAIFQFVCRGMAATQTIEQSPRMIELMEFLCVVSTDSTNLSDDAAQFMKRFPMPYENEEFITFLQTLYIGNTANGRPPVKAILQEKILSILNRSHFATTKAECISLICSIGLHSSEYKLRSLTLSFIRHVAKLNYKNLNPASSSPSSTDFSTCIVSLIRNNLHAEGWPKLQLGPQTPAFNTAILQRQLQYETLGDILKRDFELVSDLSYIEFLFESLKNDLPQFRSSIQESLLSLVGHLSILPQQSKLKLKNLLRKNLSIDEQQREDNNDAVNSIMALKFVSIKFTNAAFPFHDPEARLFNIWGTVRTNRFDIIEESFKGLQPFWFRVNNASINTSATVKTSDLLGSHLSETEFPPFREFLQVLIDQLDSEAASITRKSLNNAVRFSKQCLISNAIYGKKTMVIQDEDWSVRIDKALELDDTVVSRVNEMVQGMNDDIFIRYLTLLSNEFTATNSKGEQIAIFPYQDPIFGSVLLTLLNFVSNNVLRRLEILVPDLYHLVIMKFQSLSDNDLAVCATIIGIISTAIADSTHVKRITKIAQSQTMAETYVASYVVPRLYLKDQTNHIESDSILNLLNILTTHLSHPGTNKDMILKLVCQVTKFGLLLQVSAQERKDFLKKVMDTIQDKLINDVTAIQTWSYLSLYSTDLENSSLFQEKLLETNVSKQNDFLFSVGESLSVVAGKWSSKYLIKQIDIPNFNVEIMQQKFPATNVTTILDEIFSGCDSTKPSLRKASCIWLLSYIQYLGHLPEVSSKCNDIHLRFMRFLADRDEFIQDSAARGLSLVYEIGGSDLKESMVKGLLKSFTESTAGSASTSATGISGSVSEETELFEPGVLNTGDGSISTYKDILNLASEVGDPALVYKFMSLAKSSALWSSRKGIAFGLGAIMSKSSLEELLLKDQQTAKKLIPKLYRYRFDPFQAVSRSMTDIWNTLIPESSLTISLYFNDILDELLCGMANKEWRVREASTSALLQLIQSQPQEKFSEKMLKIWTMAFRTMDDIKDSVREVGTKFTTVLAKILARSIDVEKGVNPTKSKEILDNILPFLWGPHGLNSDAEEVRNFALTTLIDLVKHSPGAIKPFTPKLIYDFITLFSSIEPQVINYLALNAANYNIDANVIDTQRKNGVTNSPLFQTIEKLINNSDDCMMEEIINVVIKASRKSVGLPSKVASSLVIIILVKRYSIEMKPYSGKLLKVCLTMFEDRNESVNIAFAISMGYLFKVSALDKCIKYSEKLITKYFEPTSTENNKKVVGTAIDSILNYAKSEFDNVASVFMPLIFIACNDEDKDLETLYNKIWTEASSSGAGTVKLYLPEILNVLCVNIKSNDFSIRKTCAKSVIQLCGGINDSIPYPQIVKLFDISREALSGRSWDGKEHIVAALVSLTEKFSQTVADNNDLQESINHVMYTEVSRKSMKYVKKILPLYARYINVNPQEETITFLIEKAKEMIRLLGSESDDSEGSIKQTSDESTIKRIKPNTEITQKSSKENIENEEYVINLLKVSVDICNNSKSRYPMNLLEFIIDEIAYLFHNDRIIHTWRTQLAASEIGISIVGRFSTISSADFIQNVGRLWDQTFPINCNKETIENVKLQMIKFGGLIIQKIPSLQNNIEENLRLLNSIDSTSRIELELKNIGL
Protein: Cysteine rich protein (Putative calmodulin-binding protein CamBP64) (Q9GPK9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MKAIVLIIFILLINNQIVKTWDQNDVKQFFNNYPFGIKSSSGFYYDTQVSTLNGTIYGFTKNGFVDFPENPGFEESGFYLDQSVDMVEDRLGADGRPVYKNGNEPFIVTNKETGKQFTLAHNSSTFYDWFHSSPCVNYPLNGSIWITKNALQGVAFKPTNDVYPYDIGTQDNQLPYFHHSTFSLNFYLRVKRQLNRPSILNIATNYETFFFINNQKQIGELIVLGGESGLYYYQWAPEDTDDGKIFKIDIFVIMRTGFKGVLQINFRNSFDQCFCNNTDICSICNGNGDTCGCIYGATKGCASAHTKCSQCIYVNDCGNFNNTDPFCSIVKCSNNQTLSSTDSPPLSIDGSVSSGSGSNDDPTCILEPIDCDDNDECTVDECSITSGCKHTVCPNLDKSGKTEIKCVNGKCQTRVKSPCELMTCPNDTICIENYNNTKNLTICLPIECSINNCDDGNGCTIDSCNFQTGFCDHLLCPNKYLDPITNHTTIPICENNKCVNKTLSNCEYFKCDHPNEICIEEKITLAPKCVHFDSGCLSCSDLNCQSLTSPNSRCKYIEMDNQKLRCKGSVGSCCPYLPTCY
Protein: LD12638p (Q5BI22)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTNSGRNHHRFDQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKVHAYFAPGTPPAVTSGHRPRYCRCCEIL
Protein: Battenin (G5EES1)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Interaction partners:
- Alpha-mannosidase
- Battenin
- Battenin
- Probable beta-mannosidase
- Palmitoyl-protein thioesterase 1
- Coelomocyte uptake defective protein 15
- Sulfatase N-terminal domain-containing protein
- Chloride channel protein
- Sphingomyelin phosphodiesterase 1
Sequence:
MMDRVNWPTVRIAVAFFLIGLCNNYGYVIMLSAAEDILSEQHGKVKSNATDLCLPAITKRECKPPVAEVLLSDNLPSLIVKLTFPFFMDRFPFGFRVAIVCLLQATSYFVVAFSVSIPMSLAGVVFVSLGGGLGEITFLGLSAHYQRIAIAGWSSGTGMAGLLGSFSYAFLTEPHMANLTPKVALLIQLFIPVLFAFAYFILLKKPESVYSPTLDPKSWIVPKGYDDFIVSEHRVPQRELGPSDRLKLILPMLHLMIPLAIVYVGEYMINQGMTQQIVFDCAHGFNLSLHSQYRWYQVLYQFGVFVSRSSIRLVELPMWMLYLLPFLQLTNMLFFFFDALYWFVPQIAIIFALIIFEGLFGGSSYVNTFHKIHNKVEPDVREYCLSAASMGDSIGVNFAAGVSIPLHYWMCDQPARL
Protein: Homeo box B13 (D3ZWL5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Meis homeobox 2
Sequence:
MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSSPLASHPAAPTLMPTVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQTATLATYPSETPAPGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNSQMCCQGEQNPPGPFWKAAFAEPSVQHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSTTP
Protein: Alpha/beta hydrolase family protein (At1g15070/F9L1_1) (Q8RX69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g15420
- AT5g16210/T21H19_130
- F-box protein At3g59000
- Expressed protein
- Nucleic acid-binding, OB-fold-like protein
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- BZIP transcription factor-like protein
- Transcription initiation factor TFIID subunit 12
- Protein prenylyltransferase superfamily protein
- Probable galacturonosyltransferase 13
Sequence:
MSTMPPQFPLEIRSALRRASSTVYLHRSISTVTTTPSFRHRTTLLRPRAFSSSSVKLPTKPSLCTADELHYVSVPNTDWRLALWRYLPPPQAPTRNHPLLLLSGVGTNAIGYDLSPGCSFARHMSGQGFETWILEVRGAGLSTRVSDLKDVEESAHELSNQIESTARAAAGKETCSDEKQTTDIMDSSAPAPASDVSVVGEASAWDESQLVARLTSTFMSLSERLSGFLSEGQSVFMSAKLFDKIAMLVDDTQLYERFNDIRSKLLSLIESKQNSGLVNQVRDLAQRLVNLFDDGQRSVSPPLIDLQERLTATIEDFQKQLDLIVKYDWDFDHYLEEDVPAAIEYVRAQSKPKDGKLFAIGHSMGGILLYAMLSRCAFEGREPSVAAVATLASSVDYTTSNSALKLLIPLANPAEALSVPVVPLGALLAAAFPLSTRPPYVLSWLNDLISSTDMMHPEMLEKLVLNNFCTIPAKLLIQLTTAFREGGLRDRSGKFYYKDHLPRTSVPVLALAGDRDLICPPAAVEDTVKLFPENLVTYKLLGEPDGPHYAHYDLVGGRLAVEQVYPCITEFLSHHDSA
Protein: Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (Arabidopsis NPK1-related protein kinase 2) (Q9FZ36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Mitogen-activated protein kinase kinase 5
- Mitogen-activated protein kinase kinase 4
- Mitogen-activated protein kinase kinase kinase ANP1
- Kinesin-like protein KIN-7B
- Kinesin-like protein KIN-7A
- 65-kDa microtubule-associated protein 1
- Disease resistance protein SUMM2
Sequence:
MQDLFGSVRRSLVFRSTTDDENQENHPPPFPSLLADKITSCIRKSMVFAKSQSPPNNSTVQIKPPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLKCLQQEPNLRPTASELLKHPFVTGKQKESASKDLTSFMDNSCSPLPSELTNITSYQTSTSDDVGDICNLGSLTCTLAFPEKSIQNNSLCLKSNNGYDDDDDNDMCLIDDENFLTYNGETGPSLDNNTDAKKSCDTMSEISDILKCKFDENSGNGETETKVSMEVDHPSYSEDENELTESKIKAFLDDKAAELKKLQTPLYEEFYNGMITCSPICMESNINNNKREEAPRGFLKLPPKSRSPSQGHIGRSPSRATDAACCSKSPESGNSSGAPKNSNASAGAEQESNSQSVALSEIERKWKEELDQELERKRREITRQAGMGSSPRDRSLSRHREKSRFASPGK
Protein: Large ribosomal subunit protein mL43 (54S ribosomal protein L51, mitochondrial) (Q06090)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). Also has an extraribosomal function, being essential for mitochondrial genome integrity. May interact with MHR1 to take part in the mtDNA repair mechanism.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:31374566}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein uS2m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein mL41
- Small ribosomal subunit protein uS7m
- Large ribosomal subunit protein bL36m
Sequence:
MVVKAIARNSIGRNGVGAFVFPCRKITLQFCNWGGSSEGMRKFLTSKRLDKWGQEFPWIQFEVMRKSGHPLLRAEYTNGREKVICVRNLNIDNVENKLKLLKDSDGDILRRRTKNDNVESLNSSVRGIWSPLHAAKRHRI
Protein: Ribonuclease P protein component 1 (RNase P component 1) (EC 3.1.26.5) (Rpp29) (P60832)
Organism: Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00754, ECO:0000269|PubMed:20675586}.
Interaction partners:
- Ribonuclease P protein component 2
- Ribonuclease P protein component 4
- Ribonuclease P protein component 3
- Protein translation factor SUI1 homolog
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL14
Sequence:
MSQNILRHELIGLNLEVVKSTDSGLISTKGRVINETRNTLVLEKENGKEITLVKEISTFRIQFESENVVKIDIDGRLLVGRPEDRLKRKIKQLYSY
Protein: General transcription factor IIi isoform A (X5DR09)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLSKPLQGSHHSSEGNEGTEMEVPAEDSTQHVPSETSEDPEVEVTIEDDDYSPPSKRPKANELPQPPVPEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHELLNSTREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVKEDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKALQSPKRPRSPGSNSKVPEIEVTVEGPNNNNPQTSAVRTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKESTSSKSPPRKINSSPNVNTTASGVEDLNIIQVTIPDDDNERLSKVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQSESEGPVIQESAEPSQLEVPATEEIKETDGSSQIKQEPDPTW
Protein: Protein similar (Q24167)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12215541}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12215541}. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator homolog
- hypoxia-inducible factor-proline dioxygenase
- Protein Vhl
- Elongin-C
- Elongin-B
- histone acetyltransferase
- Heat shock protein 83
- Forkhead box protein O
- Cullin-2
- Blown fuse, isoform A
Sequence:
MVSLIDTIEAAAEKQKQSQAVVTNTSASSSSCSSSFSSSPPSSSVGSPSPGAPKTNLTASGKPKEKRRNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQQQQQQPQLQQQHFSNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAALLCGSGNGTLSILAGSGVTVAEECNERLQQHQQQQQQTSGNEFRTFQQLQQELQLQEEQQQRQQQQQQQQQQQQQQQLLSLNIECKKEKYDVQMGGSLCHPMEDAFENDYSKDSANLDCWDLIQMQVVDTEPVSPNAASPTPCKVSAIQLLQQQQQLQQQQQQQQNIILNAVPLITIQNNKELMQQQQQQQQQQQQEQLQQPAIKLLNGASIAPVNTKATIRLVESKPPTTTQSRMAKVNLVPQQQQHGNKRHLNSATGAGNPVESKRLKSGTLCLDVQSPQLLQQLIGKDPAQQQTQAAKRAGSERWQLSAESKQQKQQQQQSNSVLKNLLVSGRDDDDSEAMIIDEDNSLVQPIPLGKYGLPLHCHTSTSSVLRDYHNNPLISGTNFQLSPVFGGSDSSGGDGETGSVVSLDDSVPPGLTACDTDASSDSGIDENSLMDGASGSPRKRLSSTSNSTNQAESAPPALDVETPVTQKSVEEEFEGGGSGSNAPSRKTSISFLDSSNPLLHTPAMMDLVNDDYIMGEGGFEFSDNQLEQVLGWPEIA
Protein: C-C motif chemokine ligand 26 (D3ZQG2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- C-C chemokine receptor type 3
- C-C motif chemokine 5
- Eotaxin
- C-C motif chemokine ligand 27
- C-C motif chemokine
- C-X-C motif chemokine 10
- C-C motif chemokine 2
- C-X-C motif chemokine
- C-C motif chemokine
- Stromal cell-derived factor 1
Sequence:
MASQTLRSTSDGGGFLSVHTKVVRSQPATWMVSHRLREDKPGGAEEPSIKGPGEWTMKTFSLGPIVLLAVFLSVQLGVATCESEMPMPCCSYFSHYVIPWHWLYSYQITDSSCPNEGVIFTTKTGKQYCVQPGDKWVQRYISLLNAKKHW
Protein: Betaine aldehyde dehydrogenase 2 (OsBADH2) (EC 1.2.1.8) (Q84LK3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Dehydrogenase that can use N-acetyl-gamma-aminobutyraldehyde (NAGABald), gamma-guanidinobutyraldehyde (GGBald), betaine aldehyde (Bet-ald), gamma-aminobutyraldehyde (GAB-ald), acetaldehyde, 4-aminobutylaldehyde (AB-ald), 3-aminopropionaldehyde (AP-ald), 4-N-trimethylaminobutyraldehyde (TMAB-ald) and 3-N-trimethylaminopropionaldehyde (TMAP-ald) as substrates. Catalyzes the oxidation of GAB-ald more efficiently than Bet-ald. Mediates the conversion of GAB-ald into gamma-aminobutyric acid (GABA), and prevents the formation of 2-acetyl-1-pyrroline (2AP) which gives fragrant rice its aromatic properties.
Subcellular location: Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:18599581}.
Interaction partners:
- aldehyde dehydrogenase
- Delta-1-pyrroline-5-carboxylate synthase 2
- Delta-1-pyrroline-5-carboxylate synthase 1
- Os06g0258900 protein
- Betaine aldehyde dehydrogenase 1
- Os06g0698785 protein
- Proline dehydrogenase
- Os04g0573100 protein
- Os12g0604800 protein
- HOTHEAD protein, putative, expressed
Sequence:
MATAIPQRQLFVAGEWRAPALGRRLPVVNPATESPIGEIPAGTAEDVDAAVAAAREALKRNRGRDWARAPGAVRAKYLRAIAAKIIERKSELARLETLDCGKPLDEAAWDMDDVAGCFEYFADLAESLDKRQNAPVSLPMENFKCYLRKEPIGVVGLITPWNYPLLMATWKVAPALAAGCTAVLKPSELASVTCLELADVCKEVGLPSGVLNIVTGLGSEAGAPLSSHPGVDKVAFTGSYETGKKIMASAAPMVKPVSLELGGKSPIVVFDDVDVEKAVEWTLFGCFWTNGQICSATSRLILHKKIAKEFQERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKQFVSTAKSQGATILTGGVRPKHLEKGFYIEPTIITDVDTSMQIWREEVFGPVLCVKEFSTEEEAIELANDTHYGLAGAVLSGDRERCQRLTEEIDAGIIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVKQVTEYASDEPWGWYKSPSKL
Protein: Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Q580D3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRFLGAGACSIVFALSEEEAREWGHLLPSHLLWQLALRLSARKLLRCPTCCDALNDFIGFRLGIGLDDKLRERCAAAYPLFAARCQEALYAELVSNFAADPRHIQLHGGRSTSDGVGTEAMTDSWPHYSTLAMEIKPKGVWRRPAVVGVVVDGVEYYLHPIKLRQCRFSLMQLLKRKRHNHSTPVSMERRCTYCPNQLLLGDGSSIVDALQHLSEHPGNNLAILHATDAGQGLNENSIDIVSSVLRRSGILSILANLQLFGSSSSCEWPVLDIELLFRWSEARNMSSVRWIVCSTCEGQFAAESCACQSELPLSLCMETCSGIHLTHFIAPPMGFEECVERFYASVTAKDVSVLVALTISEKVELPPSLSSPPKLGMDGSAAEEKSANLCSNPRVRFIECGDTPNGVTINLEHPQAAICRVGVVDLDAKWHKPLSRYFELDREVLAAWEDYKVVSAPEFHC
Protein: Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) (P20612)
Organism: Mus musculus (Mouse)
Function: Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity).
Subcellular location: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:31696965}. Membrane {ECO:0000250|UniProtKB:P04695}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04695}. Photoreceptor inner segment {ECO:0000269|PubMed:31696965}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. {ECO:0000269|PubMed:31696965}.
Interaction partners:
- Rhodopsin
- Regulator of G-protein signaling 9
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
- Guanine nucleotide-binding protein G
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
Sequence:
MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKKAHLSICFPDYDGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
Protein: Rfx, isoform H (A0A0B4K653)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serine/threonine-protein kinase ATR
- Forkhead domain 3F, isoform D
- Ovarian-specific serine/threonine-protein kinase Lok
- Reduced mechanoreceptor potential A, isoform B
- No mechanoreceptor potential B, isoform D
Sequence:
MTTRLAPQRQFILSTRSAIVDATSPPEDSAEEQQQLTVEVESATNGVITNSTTSPPPHAEQFEFCTEDGVVVSATLEDVMTQVKLFPLLQNCQLLQKKLVDEDDDSTGVGATDADQLEVISVVLPMDAEDSTSDAHLHGHVVNSSSDTMGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQVANGQVTVVQTTEDDDGTPFITVTVSGQEQNYQVQYVDSELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKDMDFEFECQFAYITSDTEHQTTPSSASSGGDVGNEAKRLKQE
Protein: Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] (P05408)
Organism: Homo sapiens (Human)
Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01165}. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000250|UniProtKB:P01165}.
Interaction partners:
- Neuroendocrine convertase 2
- Secretogranin-3
- Secretogranin-1
- Secretogranin-2
- Chromogranin-A
- Neuroendocrine convertase 1
- Gremlin-1
- Formin-1
Sequence:
MVSRMVSTMLSGLLFWLASGWTPAFAYSPRTPDRVSEADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE
Protein: Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (Q6FTJ2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Large ribosomal subunit protein uL5
- L37
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS10
- 40S ribosomal protein S12
- L1c
- 40S ribosomal protein S26
- 60S ribosomal protein L29
- Candida glabrata strain CBS138 chromosome F complete sequence
Sequence:
MSHRKYEAPRHGHLGFLPRKRAASVRGRVKSFPKDDKSKPVALTSFLGYKAGMTTIVRDLDRPGSKFHKREIVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYSAKYAQNGAEIERELARIKKYATVVRVLVHTQVRKTPLVQKKAHLAEIQLNGGSISEKVDWAREHFEKTVSVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPAHVMWSVARAGQRGYHHRTSINHKIYRIGKGDDEGNAATNFDRTKKTINPMGGFVHYGMVNNDFVMVKGSIPGCKKRVVTLRKSLYTNTSRKAVEEVTLKWIDTASKFGKGRFQTPAEKHAFMGTLKKDL