wanglab/gogpt-training-data huggingface dataset:
Protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P) (Q9CW73)
Organism: Mus musculus (Mouse)
Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
Subcellular location: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789}.
Interaction partners:
- Carbohydrate sulfotransferase 10
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 3
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
- Brevican core protein
Sequence:
MPKRRDILAIVLIVLPWTLLITVWHQSSLAPLLAVHKDEGSDPRHEAPPGADPREYCMSDRDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVVEDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRETFPRNSTQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVGWKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPKAANCTKILVWHTRTEKPVLVNEGKKGFTDPSVEI
Protein: SAGA-associated factor 11 (Q94BV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of a deubiquitination module (DUB module) that specifically deubiquinates monoubiquinated histone H2B (H2Bub). Does not seem to be a component of the TREX-2 complex. Seems to act independently of the SAGA multiprotein complex. The DUB module is responsible for the major H2Bub deubiquitinase activity in Arabidopsis.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:30192741}. Note=Displays a rather patchy distribution forming a punctuated pattern in the euchromatin (PubMed:30192741). Does not localize in the heterochromatic chromocenters or nucleolus (PubMed:30192741). {ECO:0000269|PubMed:30192741}.
Interaction partners:
- Transcription and mRNA export factor ENY2
- Ubiquitin C-terminal hydrolase 22
- SAGA-associated factor 29 homolog B
- SAGA-associated factor 29 homolog A
- Transcription initiation factor TFIID subunit 10
- Transcriptional adapter ADA2b
- Transcription initiation factor TFIID subunit 9
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Transcription initiation factor TFIID subunit 6
Sequence:
MSGAEDNKSSHAQLSSQIFLDLVDSVIADVASECHRVARLGLDRDLDIVEEELRLSVEARAKIADPSNNLETNTKYVVDIFGQTHPPVASEVFNCMNCGRQIVAGRFAPHLEKCMGKGRKARAKTTRSTTAAQNRNARRSPNPRYSPYPNSASENQLASGSPGVAGEDCSNFTVRENVKGD
Protein: Voltage-dependent L-type calcium channel subunit alpha (A0A8I5ZS49)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MSESEVGKDTTPEPSPANGTGPGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQHNKHKTVVVASAQRSPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSITDTPGDEDEEEGTMASCTLCLNKIMKTKVCRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASGDAGAAKDKGREKSSEGNPPQENKVLVPGGENEDTEGTKSEGAAPGMEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHVFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNSSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQANQELRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGADAPTSTSSVLQAGLRSLQDLGPEIRQALTYDTEEEEEEEEAAGQEAEEEEAENNPETYKDSIDSQPQAQWNSRISVSLPVKEKLPDSLSTGPSDDDGVAPNSRQPSGLQAGSQPHRRSSGVFMFTIPEEGSTQLKGVQGQDNQNEEQEVPDWTPNLDEQAGMPSNPVLLPPHWSQQHVNGHHVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRTSGPGRAQGSWAAPPQKGRLLYAPLLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAPSDPSHRKRGSADSLVEAVLISEGLGLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTTSLYSDEESILSRFDEEDLGDEMACVHAL
Protein: Voltage-gated delayed rectifier potassium channel KCNH8 (ELK1) (hElk-1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Potassium voltage-gated channel subfamily H member 8) (Voltage-gated potassium channel subunit Kv12.1) (Q96L42)
Organism: Homo sapiens (Human)
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ETS domain-containing protein Elk-4
- ETS domain-containing protein Elk-3
Sequence:
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASASTKPLENLPLEVVTSTAEVKDNKAINV
Protein: Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1) (Q9P2X0)
Organism: Homo sapiens (Human)
Function: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Dolichol-phosphate mannosyltransferase subunit 1
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol kinase
- Dolichyl-phosphate beta-glucosyltransferase
- Dolichyldiphosphatase 1
- Dol-P-Man:Man
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- GPI alpha-1,6-mannosyltransferase 2
- GPI alpha-1,4-mannosyltransferase I, catalytic subunit
Sequence:
MTKLAQWLWGLAILGSTWVALTTGALGLELPLSCQEVLWPLPAYLLVSAGCYALGTVGYRVATFHDCEDAARELQSQIQEARADLARRGLRF
Protein: BES1/BZR1 homolog protein 3 (O49404)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g44430
Sequence:
MTSGTRTPTWKERENNKRRERRRRAIAAKIFAGLRIHGNFKLPKHCDNNEVLKALCNEAGWTVEDDGTTYRKGCKPMDRMDLMNGSTSASPCSSYQHSPRASYNPSPSSSSFPSPTNPFGDANSLIPWLKNLSSNSPSKLPFFHGNSISAPVTPPLARSPTRDQVTIPDSGWLSGMQTPQSGPSSPTFSLVSRNPFFDKEAFKMGDCNSPMWTPGQSGNCSPAIPAGVDQNSDVPMADGMTAEFAFGCNAMAANGMVKPWEGERIHGECVSDDLELTLGNSRTR
Protein: Protein phosphatase 1G (EC 3.1.3.16) (Fibroblast growth factor-inducible protein 13) (FIN13) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Q61074)
Organism: Mus musculus (Mouse)
Function: May be involved in regulation of cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:9271424}. Membrane {ECO:0000250|UniProtKB:O15355}; Lipid-anchor {ECO:0000250|UniProtKB:O15355}.
Interaction partners:
- La-related protein 7
- Ubiquitin carboxyl-terminal hydrolase 7
Sequence:
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDNETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALQDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDDKDKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCQKVPPHTKSGIGTGDEPGPQGLNGEAGPEDPSRETPSQENGPTAKGHTGFSSNSEHGTEAGQISEPGTATGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEVEEEEDDSEECSEDEDGYSSEEAENEEDEDDTEEAEEDDDEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPQEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTVELQAESGKRKLEEALSTEGAEDTGNSDKKKAKRD
Protein: Cytochrome P450 2C13, male-specific (EC 1.14.14.1) (CYPIIC13) (Cytochrome P-450g) (Cytochrome P450-G) (Cytochrome P450-UT-5) (P20814)
Organism: Rattus norvegicus (Rat)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 2E1
- Cytochrome P450 1A2
- Bifunctional epoxide hydrolase 2
- Cytochrome P450 1A1
- Epoxide hydrolase 1
- Cytochrome P450 2U1
- Cytochrome P450, family 2, subfamily j, polypeptide 4
- unspecific monooxygenase
- Arachidonate 12-lipoxygenase, 12R-type
- Polyunsaturated fatty acid 5-lipoxygenase
Sequence:
MDPVVVLLLSLFFLLFLSLWRPSSGRGKLPPGPTPLPIIGNFFQVDMKDIRQSLTNFSKTYGPVYTLYVGSQPTVVLHGYEALKEALVDHGEEFSGRGRLPICEKVAKGQGIAFSHGNVWKATRHFTVKTLRNLGMGKGTIEDKVQEEAKWLVKELKKTNGSPCDPQFIMGCAPGNVICSIILQNRFDYEDKDFLNLIEKVNEAVKIISSPGIQVFNIFPILLDYCPGNHNIYFKNHTWLKSYLLEKIKEHEESLDVSNPRDFIDYFLIERNQENANQWMNYTLEHLAIMVTDLFFAGIETVSSTMRFALLLLMKYPHVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTNAMVHEVQRYIDIGPNGLLHEVTCDTKFRNYFIPKGTAVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFIPFSAGKRMCLGESLARMELFLFLTTILQNFKLKSLVDPKDINTTPICSSLSSVPPTFQMRFIPL
Protein: Egg cell-secreted protein 1.2 (Q9SJ24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:23180860}. Secreted {ECO:0000269|PubMed:23180860}. Note=Secreted via vesicle exocytose upon sperm arrival, especially in the apical region of the degenerating synergid cell.
Interaction partners:
- U3 snoRNP-associated protein-like YAO
- Uncharacterized protein F26A9.15
- DNA polymerase alpha catalytic subunit
- Small ribosomal subunit protein uS7y
- At2g21655)
- Inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- At4g07515)
- Defensin-like protein 44
- Protein DOWN-REGULATED IN DIF1 11
- F17F8.22
Sequence:
MASNTSFLFATIAILLVLNISGRTLPETEDSTNIAARLNGGGLMECWNALYELKSCTNEIVLFFLNGETKLGVDCCQAVEVITTDCWPAMLTSLGFTSDETNVLRGFCQSPNSGGSSPAPSSVKL
Protein: Sister chromatid cohesion 1 protein 1 (Protein DETERMINATE INFERTILE 1) (SCC1 homolog 1) (Q9S7T7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in chromosome condensation, pairing and segregation during meiosis. Responsible for cohesion between replicated sister chromatids.
Subcellular location: Nucleus.
Interaction partners:
- Structural maintenance of chromosomes protein 3
- Sister chromatid cohesion protein SCC2
- Structural maintenance of chromosomes protein 1
- Structural maintenance of chromosomes protein 4
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- Structural maintenance of chromosomes protein 5
- Wings apart-like protein 1
- Wings apart-like protein 2
- Sister chromatid cohesion protein SCC4
- Protein GRAVITROPIC IN THE LIGHT 1
Sequence:
MLRLESLIVTVWGPATLLARKAPLGQIWMAATLHAKINRKKLDKLDIIQICEEILNPSVPMALRLSGILMGGVVIVYERKVKLLFDDVNRFLVEINGAWRTKSVPDPTLLPKGKTHARKEAVTLPENEEADFGDFEQTRNVPKFGNYMDFQQTFISMRLDESHVNNNPEPEDLGQQFHQADAENITLFEYHGSFQTNNETYDRFERFDIEGDDETQMNSNPREGAEIPTTLIPSPPRHHDIPEGVNPTSPQRQEQQENRRDGFAEQMEEQNIPDKEEHDRPQPAKKRARKTATSAMDYEQTIIAGHVYQSWLQDTSDILCRGEKRKVRGTIRPDMESFKRANMPPTQLFEKDSSYPPQLYQLWSKNTQVLQTSSSESRHPDLRAEQSPGFVQERMHNHHQTDHHERSDTSSQNLDSPAEILRTVRTGKGASVESMMAGSRASPETINRQAADINVTPFYSGDDVRSMPSTPSARGAASINNIEISSKSRMPNRKRPNSSPRRGLEPVAEERPWEHREYEFEFSMLPEKRFTADKEILFETASTQTQKPVCNQSDEMITDSIKSHLKTHFETPGAPQVESLNKLAVGMDRNAAAKLFFQSCVLATRGVIKVNQAEPYGDILIARGPNM
Protein: Schlafen family member 4 (Q9TPX1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSITVDQDTDYAELVLSIGEITLGEKTRKSMKDSQRRKREAKTFQQAVCTLLNSGGGVAKARIKNQNYDFSRDGVGQDLENFLPHILDFPHEYLDFKQVKDYFLMFVKAWKLKQKGPGITTLKTNLYIRSISSSIELKAVNAVKFLKSRKCSKGRSDSRLSSPGTIVCNEVLNECLNLFNRDCFTCKEKFCFTKATHAEVKLTPKENILEILPQTVSSFANADGGYLFIGLDGKTQEIIGFEAEKSDLVHLESEIEKCIRQLPVTHFCEEREKIKYTCKFMEVHKPGAACSFVCALRVERFCCAVFAAEPESWHVEDSCVKRFTAEDWVKRQMDGPACFSKQDKGPLQSSRLPHSPRSCCPDNPDALQQSAGLPVISGKVISSPEALCGKLFSTQEAHEQLLWAQLDSLPKGTLVVTKRWALDLPLQDKHGVILDTLHIPQDSLLTLHGFVLGGEDLEDDSTLLRELGAELKGYYKQTAVTLKQTLANHGSYTEKIGIAIKITYLGHNKAVSLYDSSSKIHYPTKYYLTTETAKNLEKALAEILGSRESFYSLPRQNCSDHFIFAFFLSFSFLLVFLFWSWGLNPEP
Protein: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase) (P0A9D8)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of N-succinyl-2-amino-6-oxo-L-pimelate from succinyl-CoA and tetrahydrodipicolinate, a key step in lysine biosynthesis via diaminopimelate pathway.
Subcellular location: Cytoplasm.
Interaction partners:
- 4-hydroxy-tetrahydrodipicolinate reductase
- Acetylornithine/succinyldiaminopimelate aminotransferase
- 4-hydroxy-tetrahydrodipicolinate synthase
- Succinyl-diaminopimelate desuccinylase
- Diaminopimelate decarboxylase
- Diaminopimelate epimerase
- Aspartate-semialdehyde dehydrogenase
- Lysine-sensitive aspartokinase 3
- Methionine aminopeptidase
- GMP synthase
Sequence:
MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
Protein: Protein HEAT-INDUCED TAS1 TARGET 2 (Q9FJF8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both basal and acquired thermotolerance via HSFA1s-directed pathways (e.g. HSFA1A, HSFA1B, and HSFA1D). Triggers the expression of HSFA1A and HSFA1B.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24728648}. Nucleus {ECO:0000269|PubMed:24728648}.
Interaction partners:
- Heat shock 70 kDa protein 14
- Heat stress transcription factor A-1a
- Protein SUPPRESSOR OF GENE SILENCING 3
Sequence:
MNMIQRFMQSMAKTRGLCHPDCVKASSEQEDYDASQLSIWWIMLGRKTTREKWMNQALSSLSKTCISIWWKMSGIRGKMCREREQPLTVKDCLECAFKKGLPRREHWAHVGCTFKAPPFACHIPRVPMKGEVIETKSLDEAFKLLIKQPVGARLHVFSPDLDNVGEGVYEGLSSLSRKESRYVGLRDVIIVAVNKSEGKTVATVKICYKKKTSFVKVCLSRMFVQLGGGEESQVKEPTGLLVDFCIPRLSIN
Protein: Pyruvate kinase (PK) (EC 2.7.1.40) (Q10208)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Glucose-6-phosphate isomerase
- Enolase 1-1
- Enolase 1-2
- Probable L-lactate dehydrogenase
- Phosphoglycerate mutase
- Phosphoglycerate kinase
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- NAD-dependent malic enzyme
- Pyruvate carboxylase
- Fructose-bisphosphate aldolase
Sequence:
MSSSAVSPKQWVAGLNSELDIPAVNRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLFPLAIALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVIQPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKADLRFGVKNGVDMIFASFIRRAEDVIHIREVLGEEGKNIKIICKIENQQGVNNFDSILDVTDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVSDVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFGLVRRPLECATETTAVAAIGASIESDAKAIVVLSTSGNTARLCSKYRPSIPIVMVTRCPQRARQSHLNRGVYPVIYEKEPLSDWQKDVDARVAYGCQQAYKMNILKKGDKIIVLQGAVGGKGHTSIFRLTVAE
Protein: VQ motif-containing protein 4 (AtVQ4) (MPK3/6-targeted VQ-motif-containing protein 1) (Q5M750)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as negative regulator of WRKY33 transcription factor activity in the promotion of defense gene expression. Acts as a negative regulator of pathogen-associated molecular pattern (PAMP)-induced responses to modulate resistance to pathogens.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9M9F0}.
Interaction partners:
- Sigma factor binding protein 2, chloroplastic
- Protein MKS1
- Sigma factor binding protein 1, chloroplastic
- Probable WRKY transcription factor 33
- VQ motif-containing protein 9
- VQ motif-containing protein 29
- VQ motif-containing protein 10
- VQ motif-containing protein 22
- Protein HAIKU1
- Calmodulin-binding protein 25
Sequence:
MENSPRYREATNLIPSPRCHNSNNSCGMSSSSESNKPPTTPTRHVTTRSESGNPYPTTFVQADTSSFKQVVQMLTGSAERPKHGSSLKPNPTHHQPDPRSTPSSFSIPPIKAVPNKKQSSSSASGFRLYERRNSMKNLKINPLNPVFNPVNSAFSPRKPEILSPSILDFPSLVLSPVTPLIPDPFDRSGSSNQSPNELAAEEKAMKERGFYLHPSPATTPMDPEPRLLPLFPVTSPRVSGSSSASTS
Protein: Non-selective voltage-gated ion channel 2 (Outer mitochondrial membrane protein porin 2) (Voltage-dependent anion-selective channel protein 2) (VDAC-2) (P40478)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P04840}.
Interaction partners:
- Mitochondrial import receptor subunit TOM40
- Non-selective voltage-gated ion channel 1
- Sorting assembly machinery 50 kDa subunit
- Prohibitin-2
- Cytochrome c isoform 2
- Mitochondrial import receptor subunit TOM22
- Cytochrome c isoform 1
- Mitochondrial import receptor subunit TOM20
Sequence:
MALRFFNDISRDVNGLFNRDFFHTNPLSLNISTTTENGVNFTLKAKQGVTEGPIQTSVEGRFYDRKEGVSLSQSWSNQNRLNTRIEFSKIAPGWKGDVNAFLTPQSIKNAKFNLSYAQKSFAARTSIDILQPKDFVGSVTLGHRGFVGGTDIAYDTAAGLCARYAMSIGYLAREYSFILSTNNRQCATASFFQNVNRYLQVGTKATLQSKTSSNMNIEFVTRYVPDSISQVKAKIADSGLTTLSYKRNLNKDISLGVGMSFNALQLTEPVHKFGWSLSFSP
Protein: Sll0822 protein (Q55432)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Sll1734 protein
- Ssr2551 protein
- NAD
- Ycf51-like protein
- Cytochrome c-553-like
- Ssr0332 protein
- Slr2144 protein
- Slr1302 protein
- Thylakoid membrane protein slr1949
- Sll1926 protein
Sequence:
MAKSNATKPLTGEALLEKVKELGDLPKEEKAKICGYVTSTKKGLPRVNMMKFYNALMDAQGIDLDSSASGQGRGGRSASYRISVQSNGNLLIGAAYTKKMSLNVGDEFEITLGRKHIHLKQVGADDEEE
Protein: GSK-3-binding protein (GBP) (O93343)
Organism: Xenopus laevis (African clawed frog)
Function: Binds GSK-3 and prevents GSK-3-dependent phosphorylation. Regulates the stability of beta-catenin in embryos. Maternal GBP is required for dorsal-ventral axis formation.
Interaction partners:
Sequence:
MPCRKESFLLLEQSVTVGSGEVDTLVARIGEALQLNAQRTPTSCSMAYGALKPVSRAGPSCSCVRGRSTPYPVCTPRGAARHAQHHHHHSPRQQGTGGNKRLCGRGWGRCNCRKHAGTEEEDDPHELLQELLLSGNLIKEAVRRLHMAGESPDPPGSRRVSECTETTVQ
Protein: Uncharacterized protein C12orf60 (Q5U649)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSESEKDKERLIQAAKMFFFHVQDLASVINTLTELFSRSMNTQILLMAVKNNSYIKDFFEQMLKIFKEMQSVVDARHDKIQKESLCSKVAMAMCSVVQKSTNVEELHQSAKEVFKSAHTPVIISVLNSSNILGSLESSLSHLMKFPIMNLQLSDFYTEDTKEQSDVTTSERTRSPPGSSKTTMIDTLKKLQDVLKTEDSKNPTKSAADLLEQIVKAMGPILEILQKAIKTMEMNISVFKKASDK
Protein: Putative diacylated glycolipid transporter LprF (Lipoprotein LprF) (P9WK47)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity). Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).
Subcellular location: Cell membrane {ECO:0000305|PubMed:12581360}; Lipid-anchor {ECO:0000305}; Extracellular side {ECO:0000305|PubMed:12581360}.
Interaction partners:
- Sensor protein KdpD
- Lipoprotein LpqN
- Probable conserved membrane protein
- Lipoprotein LpqH
- Probable lipoprotein aminopeptidase LpqL
- Uncharacterized PPE family protein PPE42
Sequence:
MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG
Protein: Nucleic acid binding protein, putative (Q385A7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA polymerase sigma, putative
- Nucleic acid binding protein, putative
- Poly
Sequence:
MQEGKSIKPNGLVRCSLHGLLRFSTHCNALPVFDADQVVTGYIYQCKDGGRCMVEDTSADASARRQTPRERAESRSEAAPKKLVIDGEPSDTKPAMVSDADGAGSRQQACKSETQRGPSRYYDLATQRAVGPIKKVCWVCGMEGHEKPDCHNSLCKTCHSVRRHHHICQEVQTSPFVTICSGDTRSKEMLAVQCTSCSGFGHFDCSPRLEPSFPSCCFCGEEGHNVFNCESRARTVADPWVNAALALERSGVPSRRRDRGADSTGSYASPSRSWGRHDYRGRGDGRSYPRDGVYNEIVNPYRHHEREYHAGHSGSYHNPPRYASRDGSWRRRENQNDGGSANASYDYRGDRMHESDDRNHSHSHRHHNTNYATEHMPQREYMDSRGSRQRVPVLDCRYQPRSGNSNRTKNYTDDDEYYDKFF
Protein: ADP-ribosylation factor GTPase-activating protein glo3 (ARF GAP glo3) (Q10367)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum (By similarity).
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable coatomer subunit beta'
- Probable coatomer subunit gamma
- Coatomer subunit beta
- ADP-ribosylation factor 1
- Coatomer subunit delta
- Uncharacterized protein C622.14
- Putative coatomer subunit alpha
- Probable coatomer subunit zeta
- Protein transport protein bet1
- Probable coatomer subunit epsilon
Sequence:
MTATKEESQKLLTSLRSQRDNKVCFDCGAKNPTWSSTTFGIYLCLDCSAAHRNMGVHISFVRSTVLDSWTYAQLRVMRVGGNENARNYFKRHGGVSLLNSKDCRLKYSSKTAKQYLEKLKSLAVEDEANYPDILDMDFLSNTHEGSSAADTTNEDDDFFSAWDKASVKKSDDNLDDKTDLASTSSSVVVESGEKDEPVVVTEEKTMVSPPSRPDSTSTTKSKTSSISSARARPIRASSRPTASKLGASRPQKLGIKKANADIDFDEFEKAVLSSESAPTKKPAAVASKESTVDTLVDNGVEEVKESTSTTVQGKPVKPVLKSAASAKSTKSDDSNLNANFARLGFGQFAAASNARAKAAAKARELKKNEVNAPTYARDHFASQKSISSDQYFGRGSFDPEAAAEAQERLSSFRDATAISSKSYFGEEEDENEEGESSHRPDSAYLRDIAETATEDIEAIKVAIHQGAEKLSDFIQKVGARYNF