wanglab/gogpt-training-data huggingface dataset:
Protein: Glutathione S-transferase family protein (F4JU03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glutathione S-transferase TCHQD
- Mitochondrial outer membrane import complex protein METAXIN
- Glutathione S-transferase Z1
- Glutathione S-transferase F2
- Glutathione S-transferase DHAR2
- Nudix hydrolase 18, mitochondrial
- Glutathione S-transferase F12
- Gamma-soluble NSF attachment protein
- Ubiquitin-activating enzyme E1 1
- HVA22-like protein h
Sequence:
MSYSTIISNTSFLSLASKFTTRGSRLQCTVSMARSAVDETSDSGAFQRTASTFRNFVSKDSNSQFPAESGRYHLYISYACPWASRCLSYLKIKGLDDAISFSSVKPIWGRTKETDEHMGWVFPGSDTEVPGADPDHLNGAKSVRELYEIASPNYTGKYTVPVLWDKKLKTVVNNESAEIIRMFNTEFNHIAGNPDLDLYPSHLQAKIDETNEWIYNGINNGVYRCGFAKKQGPYEEAVEQVYEALDRCEEILGKHRYICGNTLTETDIRLFVTLIRFDEVSSYFQSKKKKYTICERISNVETLIQVYAVHFKCNKKLIREYPNLFNYTKDIFQIPGMSSTVNMNHIKQHYYGSHPSINPFGIIPHGPNIDYTSPHDRHRFSK
Protein: Peptide tyrosine arginine (P84815)
Organism: Lithobates sevosus (Dusky gopher frog) (Rana sevosa)
Function: Mast cell degranulating peptide. Inhibits granulopoiesis in human bone marrow in vitro. Causes histamine release from rat peritoneal mast cells in vitro. Does not induce apoptosis of human neutrophils in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:15808903}.
Interaction partners:
Sequence:
YLKGCWTKSYPPKPCFSR
Protein: HTH-type transcriptional regulator ArcR (Q2FUY1)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN(6)TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:17557828}.
Interaction partners:
- Glutamate synthase, large subunit, putative
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- Arginine-ornithine antiporter
- Tetratricopeptide repeat protein
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- Arginine deiminase
- Uncharacterized protein
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
Sequence:
MTENFILGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIYFLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELMAFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLICHLCQTVGYDQDEFYEIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
Protein: Small ribosomal subunit protein uS19v (40S ribosomal protein S15-6) (Q9FML6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS12y
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein eS24z
Sequence:
MAINEPEFATAVAVATKKRTFKKFSFRGFNVDALLKMSNVDLAKLFNARVRRRFYRGLKKQPLILIKKLRRAKKEASDENKMKPEVVKTHLRNMIIVPEMIGSVVGVHNGKKFNEIVIKPEMIGHYLAEFSMTCKKVNHHRPRICGCCCFRRSTRFIPLR
Protein: proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) (Q72GR9)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
Sequence:
MEFGFWSALYIFVLTAFLGYELITRVPVILHTPLMSGSNFIHGVVVVGAMVVLGHAETGLEKLIGFLGVILGAANAAGGYAVTVRMLEMFERKPGQGGGR
Protein: Calcium load-activated calcium channel (CLAC channel) (Q9FG04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- Arginine/serine-rich-like splicing factor
- Protein yippee-like At5g53940
- Nicalin
- BOS complex subunit TMEM147
- AT1G11360 protein
- Probable pectinesterase/pectinesterase inhibitor 25
- Vesicle-associated protein 1-2
- At4g24330
- Uncharacterized protein At5g49945
- At3g56360
Sequence:
MATAIPLFASFKYADSLTVVGISFCTALVCEAISWILIYRTSSYKSLKSSIDKASKKLETMKTDNPSSKLTNKKSKTKKIDRVESSLKESSRDLSLFKFKSGAVVALVLFVVFGLLNSLFEGKVVAKLPFHPITIVRKMSHRGLKGDDSTDCSMAFLYLLCSISIRTNLQKFLGFSPPRGAAGAGGLFPMPDPKTN
Protein: Junctional adhesion molecule 2A precursor (cDNA, clone cssl:d0187) (A4JYM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLVCVSLLILIHSVPVSPVTVSSRNPKVEVHEFSDAELSCEFKTEKDTNPRIEWKRKDKEKDVSFVYYGERFVGPFQDRADIEGATVRLRRVTQADAGEYRCEVSAPSDSISLGETNVTLRVLVPPQTPSCDVPSSALTGSQVELRCRDRHSIPPAVYTWYKDNRALPIRHPNATYTVNEFTGVLMFQTVSRSDAGQYHCEAKNGVGPPKSCQHTHMQIDDLNVAAVVSAVVLVCVILVLCAFGVCLAHRQGYFSRHRGRSFWIPHCHGVTHISSQNLNPSEHTQHSGYSHPPKEPQDFKHTQSFML
Protein: Non-SCF-type F-box protein ROY1 (Repressor of YPT52) (Q04847)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-SCF-type F-box protein involved in the endocytic with the vacuolar sorting pathway. Acts as a repressor of YPT52 by inhibiting the formation of active, GTP-bound, YPT52. Involved in the defense mechanism against methylmercury toxicity.
Subcellular location: Cytoplasm. Nucleus. Cytoplasmic vesicle membrane; Peripheral membrane protein.
Interaction partners:
- Suppressor of kinetochore protein 1
- GTP-binding protein YPT52
- F-box protein YLR352W
- F-box protein HRT3
Sequence:
MAFQDQDIFIVFSHASLFLNQNDLLSLSLTSKKMHDMIAIPRLYSNIHITKNPVLRTNKWFLDGGKTYVSGYRSVLKTGDKNDIFLYDRIERLLETSHLKCIKQLTIDEDLFHNREEGLQLLQRLVNEITDLDVIESLDIKDPTLFELCSAKYYRLSSLKKRVVYGETGFDGIKLWQNFKSLKWQLPESLDLQNVIIPEVGVMLMKQLNGGELEIKDEAYSSLRVFEYFDSLNLRFKNLRRLKLNHVHKQGDGSATSMRLSSRAFKDVVNLSNLKALELEFSCEVDDCECDDDFLQDITGNLVSLTSLGFIEKTFTKKGYHYMDEKWDLVVNKFILNLPNVSKDLRLLSIRHDPPLNGKGIDTVDGNLLRRKKLYEKVLPKLTSLETIIAPTVLQSITSYEMYACDLLWNGCKCAFCSKYLPLFDKYIMNHQYFSTPDARYLDIIPIVFAAYTGKSLAKRFDPQKNWDLDLLQYAPEDTTWNFHGFERIHHFASYECYFDESSFEPLATIISHFFYPYMNYLIKILPNLRQTMLSGIYFSVSPELHTYETIYD
Protein: Scarecrow-like protein 26 (AtSCL26) (GRAS family protein 23) (AtGRAS-23) (Q9SUF5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Scarecrow-like protein 29
- Protein PAT1 homolog
- Putative scarecrow-like protein 16
- Serine/arginine-rich SC35-like splicing factor SCL30A
Sequence:
MNYPYEDFLDLFFSTHTDPLATAASTSSNGYSLNDLDIDWDCDFRDVIESIMGDEGAMMEPESEAVPMLHDQEGLCNSASTGLSVADGVSFGEPKTDESKGLRLVHLLVAAADASTGANKSRELTRVILARLKDLVSPGDRTNMERLAAHFTNGLSKLLERDSVLCPQQHRDDVYDQADVISAFELLQNMSPYVNFGYLTATQAILEAVKYERRIHIVDYDINEGVQWASLMQALVSRNTGPSAQHLRITALSRATNGKKSVAAVQETGRRLTAFADSIGQPFSYQHCKLDTNAFSTSSLKLVRGEAVVINCMLHLPRFSHQTPSSVISFLSEAKTLNPKLVTLVHEEVGLMGNQGFLYRFMDLLHQFSAIFDSLEAGLSIANPARGFVERVFIGPWVANWLTRITANDAEVESFASWPQWLETNGFKPLEVSFTNRCQAKLLLSLFNDGFRVEELGQNGLVLGWKSRRLVSASFWASCQTNQ
Protein: Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) (O70342)
Organism: Mus musculus (Mouse)
Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-neuropeptide Y
- Peptide YY
- Pancreatic polypeptide prohormone
- Pro-opiomelanocortin
- Somatostatin receptor type 1
- Somatostatin receptor type 5
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
Protein: Repressed by EFG1 protein 1 (PRY family cell wall protein 2) (Q59ZX3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cell wall protein involved in cell wall integrity and which plays a role in virulence.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:20167299, ECO:0000269|PubMed:20641015, ECO:0000269|PubMed:21622905, ECO:0000269|PubMed:23136884}.
Interaction partners:
- Secreted beta-glucosidase SIM1
- Chitinase 3
Sequence:
MKITNTLLNAAALLAVTEAATITKFFTASTQTLFVTQTSQTVVATKSFVETIYSAPPKQLTSKTQDSTSPTTSSVNSLTSSSATSYVETTTPAPSSSTLTTSTISSSTASEDSDATPTADVEFAEEILKEHNVKRALHGVPALSWSNKLAEYAQDYANTGFDCSNLNLKHSGGPYGENLAAGYMGGISPVDAWYDEISMVDWNNVDFTESTGHFTQLVWRSTTQVGCAKMMCSTAWRQITVCEYLPRGNVIGLNVTSGHSYFVDNVLPPLK
Protein: N-alpha-acetyltransferase MAK3 (EC 2.3.1.256) (N-acetyltransferase MAK3 homolog) (AtMAK3) (Protein PHOTOSYNTHESIS ALTERED MUTANT 21) (O80438)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably required for N-acetylation of some chloroplast precursor proteins and efficient accumulation of thylakoid multiprotein complexes. In yeast, can replace the NatC complex (composed of MAK3, MAK10 and MAK31) by acetylating N termini of endogenous proteins and the N-terminus Met of L-A virus Gag protein. However, the formation of a NatC complex is not required for this function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12897255}.
Interaction partners:
- MAK10 homologue
- DCC family protein At1g52590
- N-terminal acetyltransferase B complex auxiliary subunit NAA25
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein E
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- Small nuclear ribonucleoprotein-associated protein
- Small nuclear ribonucleoprotein-associated protein
- Protein ECERIFERUM 16
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Sequence:
MEKEMEDKEEFDEGEIEYTSYAGEHHLPLIMSLVDQELSEPYSIFTYRYFVYLWPQLCFLAFHKGKCVGTIVCKMGDHRQTFRGYIAMLVVIKPYRGRGIASELVTRAIKAMMESGCEEVTLEAEVSNKGALALYGRLGFIRAKRLYHYYLNGMDAFRLKLLFPKPRVPQIPSQVQTQQEYETFPRPRVP
Protein: Elongation factor Tu (A0A384ME17)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MTTMAAATLLRATPHFSGLAAGRTFLLQGLLRLLKAPALPLLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEGRDPELGLKSVQKLLDAVDTYIPVPARDLEKPFLLPVEAVYSVPGRGTVVTGTLERGILKKGDECELLGHSKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIKPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPEKELAMPGEDLKFNLILRQPMILEKGQRFTLRDGNRTIGTGLVTNTLAMTEEEKNIKWG
Protein: COMM domain-containing protein 9 (Q8K2Q0)
Organism: Mus musculus (Mouse)
Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9P000}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9P000}.
Interaction partners:
- COMM domain-containing protein 6
- COMM domain-containing protein 2
- COMM domain-containing protein 4
- Coiled-coil domain-containing protein 22
- COMM domain-containing protein 5
- COMM domain-containing protein 10
- COMM domain-containing protein 3
- COMM domain-containing protein 1
- Coiled-coil domain-containing protein 93
- COMM domain-containing protein 8
Sequence:
MAALTAEHFVALQSLLKASSKDVVRQLCQESFSSSCLDSESLLDKTCSSLSVPQGEAAQLLQALHHFTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIIVEHISTWRAEAQANQISLPRLVDLDWRVDIKTSSDNISRMAVPTCLLQMKIQEDPSLCGEKPSISAVTMELSKETLDTMLDGLGRIRDQLSAVANK
Protein: Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2) (Q9NZL4)
Organism: Homo sapiens (Human)
Function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Interaction partners:
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 1A
- Ubiquitin-like protein FUBI
- BAG family molecular chaperone regulator 1
- Heat shock protein 105 kDa
- E3 ubiquitin-protein ligase CHIP
- BAG family molecular chaperone regulator 2
- DnaJ homolog subfamily B member 1
- Heat shock 70 kDa protein 4L
Sequence:
MSDEGSRGSRLPLALPPASQGCSSGGGGGGSSAGGSGNSRPPRNLQGLLQMAITAGSEEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQPMPPTAGEAEQAADQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQHEEYQEELEFCEKLLQTCFSSPADDSMDR
Protein: Nucleoporin NUP170 (Nuclear pore protein NUP170) (P38181)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution. {ECO:0000269|PubMed:10684247}.
Interaction partners:
- Nucleoporin NIC96
- Nucleoporin POM152
- Nucleoporin NUP84
- Nucleoporin NUP188
- Nucleoporin ASM4
- Nucleoporin NUP53
- Nucleoporin NUP192
- Nucleoporin NUP157
- Nucleoporin NSP1
- Nucleoporin NUP57
Sequence:
MFQSFFHNNGPAAAGETFSDSRSYPLTNHQEVPRNGLNELASSATKAQQQPTHILNSYPITGSNPLMRASAMGATSGSINPNMSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPVLDERSYYNSGVDYNFSREKNGLGAFTPFEKQDVFNIPDEILHEFSTSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMELFMFAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGQASGLNIWELHYSGSDDWFNSKCSKVCLTKSALLSLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQETITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRIIGTTTARAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEVIQQELLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQQTHQQEKKENSSVTGTTATAGSKTVKQQPVTLQHKLFVSVPDYGILKTHGKYVENATFLETAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVAVLTSTSIEIYKYRTPDEIFEDLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRYSVSTVSSLLSKPTLSTATTNLQQSITGFSKPSPANKEDFDLDDVILSPRFYGIALLITRLLRDIWGRHVFMTFTDNRVTSHAFISSSDPITPSINNLKSDEISQNRNIISKVSISKDCIEYYLSSINILNEFFITYGDSISQISAPYVLANNSNGRVIDKTEEVANQAESIAINAMIKMVQSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNDKTKSLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGLRNYDSLNYHLKNATALLEQIVDDLSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLACQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEKKQSSKTQNQISISNDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNILWVYYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQDSEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSDNSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLGICFYKE
Protein: FXYD domain-containing ion transport regulator 7 (P59649)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000269|PubMed:22535957}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P59648}. Note=Able to translocate to the plasma membrane of Xenopus oocytes independent of its association with NKA (PubMed:22535957). Lacks a cleavable signal sequence (By similarity). {ECO:0000250|UniProtKB:P59648, ECO:0000269|PubMed:22535957}.
Interaction partners:
- FXYD domain-containing ion transport regulator 3
- FXYD domain-containing ion transport regulator 4
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit gamma
Sequence:
MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIIIISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV
Protein: Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) (Q9BZR6)
Organism: Homo sapiens (Human)
Function: Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12426574, ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991, ECO:0000269|PubMed:16712417, ECO:0000269|PubMed:18411262}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PI8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99PI8}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250|UniProtKB:Q99PI8}.
Interaction partners:
- Reticulon-4
- Myelin-associated glycoprotein
- Tumor necrosis factor receptor superfamily member 16
- Aminopeptidase N
- Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
- Tumor necrosis factor receptor superfamily member 19
- Oligodendrocyte-myelin glycoprotein
- Dyslexia-associated protein KIAA0319-like protein
- Adhesion G protein-coupled receptor B1
- Ribosomal RNA small subunit methyltransferase NEP1
Sequence:
MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
Protein: Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B) (Q99453)
Organism: Homo sapiens (Human)
Function: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Achaete-scute homolog 1
- Dopamine beta-hydroxylase
- Heart- and neural crest derivatives-expressed protein 2
- Endothelin-3
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Insulin gene enhancer protein ISL-1
- Tyrosine 3-monooxygenase
- Glial cell line-derived neurotrophic factor
- Trans-acting T-cell-specific transcription factor GATA-3
- Endothelin receptor type B
Sequence:
MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF
Protein: AT25567p (Q9VC66)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH13213p
- Dystrobrevin, isoform F
- Lateral muscles scarcer, isoform B
- LD27564p
- LD42868p
- NAD
Sequence:
MAEKSLAMDGTVPEAKYQKLATEYSKLRAQATVLKKAVLEEQSKEASLREQLQQYATSLRRTEQEVDSLGFRNKQLESRVSQLQQEISVHEQPKKKDKDSGGRRGVQSNSRPDADPSLDAAQEALIFEELQKKIMENAQLTSLIDDKQRDLLLHTERIASLEQKLEKRIGDQNELEKRLRKEVETLQHRNSELETKLVDAASMLGSEDALSATGSDTTPLHNLQQQSNSNQLTSEDRIALLEKEAAHWRAQFEVAKLHQAFVSNPSKDLSTCSCSTAAAGVTVRPAESEAKGSQRARDSLQDPPEPPTKEQLIYSVFSKKFEDLMRLKVQAESKLRSYELEVQHLQNCLENATHELKAKDDQLASLGGALQMLEEELTTTRINYEEQISVLTEQVISLSDQLAACK
Protein: Heterogeneous nuclear ribonucleoprotein A/B L homeolog (Hnrpab-prov protein) (Q7ZYE9)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDTEQQCLETNAENGHEACDAEAAEDKAPAGQNGAEGEQINASKGEEDAGCVADISSPLTEGVKMFVGGLSWDTSKKDLKDYFAKFGEVSDCTIKMDPNTGRSRGFGFILFKDAESVDKVLEHKEHRLDGRLIDPKKAMAMKKDPIKKIFVGGLNPEAGEDQIREYFETFGEIEAIELPMDPKTNKRRGFVFITFKEEDPVKKILEKKFHNVSGSKCEIKIAQPKEVYQQQYGGRGGSFGGRGGRGGKGQGQNWNQGYNYWNQGYGNQGYGGYGQQGYGGYGNYDYSGYGYYGYGPGYDYSQGSANYGKAPRRGSHQNNYKPY
Protein: Ras-related protein RabJ (Q8MYF2)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rab GDP dissociation inhibitor
Sequence:
MDPLSISMESKVVLLGSSDVGKTALSLRYVDGIFPKRLTSTIGASFLTRTINIEGNKIKYLIWDSAGQDRFRSLATLYYRGACVAILVFDITQQKTFDIVKGWVEELKANIQEEIIMVLCGNKIDLEQNRQVKSETAKLYADEINAMYVETSAKENEGVEGMFLEIGKKLILNKHNEYFKQFQQQQKLHKQFQQQNQSLYQYHIQQQKHQQQQQQQQQQIFKNQQFYNNGHLQGSINGHNNQNSTNYSDNSDQCCG
Protein: Prpf8 protein (Q4FZS3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
TISSYTAFSRLILILRALHVNNDRAKVILKPDKTTVTEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPSQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Protein: WASH complex subunit 2A (F8W7U3)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004146}.
Interaction partners:
Sequence:
MPRLSGKSVRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ