wanglab/gogpt-training-data huggingface dataset:
Protein: Squalene monooxygenase SE1 (EC 1.14.14.17) (Squalene epoxidase 1) (PgSQE1) (SE) (SE1) (gse) (O48651)
Organism: Panax ginseng (Korean ginseng)
Function: Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways. Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway (By similarity).
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:P32476}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32476}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32476}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32476}.
Interaction partners:
Sequence:
MNSSSSTTTTDTLHSFMEASALLIDQYFLGWIFAFLFGFLLLLNFKRKREKNNSTEFGTDDSNGYYTPENIAGSTDVIIVGAGVAGSALAYTLANDGRRVHVIERDLTEQDRIVGELLQPGGYLKLIELGLEDCVNEIDAQRVFGYALYMDGKNTRLSYPLEKFHSDVAGRSFHNGRFVQRMREKAASLPNVRMEQGTVTSLVEKKGSVKGVQYKTKDGQELSAFAPLTIVCDGCFSNLRRSLCNPKVEVPSCFVGLILENIDLPHINHGHVILADPSPILFYKISSTEIRCLVDVPGQKVPCISNGELANYLKTVVAPQVPKQLYNSFIAAVDKGNIRTMPNRSMPADPHPTPGALLLGDAFNMRHPLTGGGMTVALSDIVLIRDLLRPLRDLHDSSTLCKYLESFYTLRKPVASTINTLAGALYKVFCASPDKARQEMRNACFDYLSLGGICSQGPIALLSGLNPRPISLFLHFFAVAIYGVGRLLIPFPSPKRMWLGARLILGASGIIFPIIKSEGLRQMFFPAIVPAYYRAPPIH
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.26) (A0A8I6GL04)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATGLGEPIYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLPPLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) (Q9UEE5)
Organism: Homo sapiens (Human)
Function: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
Subcellular location: Nucleus {ECO:0000269|PubMed:9786912}.
Interaction partners:
- Kalirin
Sequence:
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Protein: Mohawk homeobox (D3ZUL2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Tenomodulin
- Scleraxis bHLH transcription factor
- Fibromodulin
Sequence:
MNTIVFNKLGGAVIFDDRGTPDRERGSRPYGGVLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGARPGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSADDSCSEDGENPPRTHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDKGDSTANRRGPSKDDTHWKEINAAMALTNLAQGKDEAQGTTTSCIIQKSSHIAEVKTVKLPLVQHF
Protein: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (O80846)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038170}.
Interaction partners:
- tRNA
- Putative tRNA
- Ribosome biogenesis protein WDR12 homolog
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- tRNA
- Putative rRNA methyltransferase
- Phosphatidylinositol N-acetyglucosaminlytransferase subunit P-like protein
- rRNA methyltransferase 2
- tRNA
- tRNA
Sequence:
MELNKDQTVMSEDKKPQDPNPRFACEGCSVLLDINDGDRLVFARLSSGAILKIGNKNYSLKPLIGAPFGSLFQVETGEDGSFLSRILPIKQESNSNNVMDDSRDNREIVDNNEAQNLTGEEIEAMRREGAKGDEIIEALIANSKTFDKKFQLSQEKYKLKKQKKYAPKLLLRRPFARSICEAYFKKYPARIGFLRVDALSLLLTMANVTAYSDVLVVDMVGGLVTGAVAERLGGTGYVCNTYKGSSPYPVEMVRMFNFSDKVLKRIVQSSINELSSAKTASTEGNNQQEGVCKAENNINETATSDVMVEEISVTTEAGVVDIVVPESKIIKAAKAGAKASKETIEMWQENGFSSLIMAAQDQDPWIVAKDVLPLLSYSAPFAIYHQYLQPLATCMHKLQQGKMAINLQITEPWLREYQVLPSRSHPHMQMSSFGGYVLSGIRISTT
Protein: MORN repeat-containing protein 4 homolog (Retinophilin) (undertaker) (Q9VN91)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina.
Subcellular location: Membrane {ECO:0000269|PubMed:20107052, ECO:0000269|PubMed:25822849}; Peripheral membrane protein {ECO:0000305}. Cell projection, rhabdomere membrane {ECO:0000269|PubMed:20107052, ECO:0000269|PubMed:25822849}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with ninaC in the rhabdomere membrane. {ECO:0000269|PubMed:20107052, ECO:0000269|PubMed:25822849}.
Interaction partners:
- Neither inactivation nor afterpotential protein C
- Protein kinase C, eye isozyme
- Opsin Rh1
- Opsin Rh3
- Opsin Rh4
- Inactivation-no-after-potential D protein
- Guanine nucleotide-binding protein subunit beta-2
Sequence:
MAMDDYDDDMSSVGVTTARIENQHQQHPHQQGQHGHHQQGQGQSQYSAGAVKVGGWRYEDASRYIGEWNQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEGEFRGGKIWGLGLLTFQDFTHGFPRNEGFFQDCRFMRRRRCPEVVQRAQKCALMARSQCEHPY
Protein: Ankyrin 2, isoform X (M9PBV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVTENGAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVKDLIAKKITDHIDTVYLMQLFWIRHQEFFI
Protein: Buddy of Hmr 1 (LD18667p) (Q9VAY8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Buddy of Hmr 2, isoform A
- LD28380p
- Protein HGH1 homolog
- Nicalin
- Uncharacterized protein
- Sister chromatid cohesion protein DCC1
- LD14179p
Sequence:
MYPAQPAKVALAGQPISAGKPPRHSPVQMKSIPLPVFELPEYVCVETKWVTRKYAIENGIPVKELHAPITNGGATESPKKSVQQKRLNEVTGMFANEAMVPRRERAIQTENAGTKDAGIQCRRDSEEWYLPEERPKDTGSEASNSDKFLTYVSENTFIFPNGMMECAVCGDVAKTLLEHQSHMTAHYGPGALCFRCGQRLDHQKQLKQHSLSCPALAPRKSSMLFKCPHLLCNAMSHSEMQLLRHLRNHSGRKCYRCLQCKRYFKTTTSLLVHRKKEQSCAKAKVVVLFREHNGLPNGRGDPRRCSVCLKRFSSERVCLRHRRQCILGHFRRLSRVLKKEL
Protein: TRAF-like family protein (F4IV59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEIVGHRGGWGDFPGKGVGSCVFGGGGGGPAFGGRGGGPGRGYGGGPRVHGPGYGIGSRGPDPGPGFFFGGAGPGPGYGGGGGHGPGYGGGGDGRGYGSETGGGNHGPEVTRTLRDEPPSHRILTITNFSEIIGREEPYESSVFEAYFEHKWRLILYVNGNQNDGGSNHISLYLRSEETDHLTYDGSINFVLKLFVYNGKQDKYLTVTDGIQKRYNYKNKEWGYGKLIPLSTFLDTSQGYLEQDTASFGAEIFLCPPIQVQEKVTFISNPPNNVFTWKILHFSTLEDIVYYSDDFLVEDRYWRLGVNPKGTGDGRSQAIKIFLYAQGHKPNAVVSSTWGAVNLRVKNQRSSNHSQIYSAALYPIRNDYGVGVNTVLSLAELNDAVKEYLVNDSIIFEAEMVKVSVTNIVPI
Protein: Serine/threonine protein phosphatase 2A regulatory subunit (B7Z0L6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNEALDPTIKSSTSAATPTAAASETTTTAASSVVETTTTIAAATASAAESKNETTATNNNSNTSGSISSSSSNNIVIPASATNGIKESNSNLSTTTTAAAVAAATTVEGVAPAITSTIVVTGGTPPLSSLANKLKDNTPPYDAPPPTPISKVLNITGTPIVRKEKRQTSARYNASKNCELTALIPLNEKTAASEREELFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRTLPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQQVESLAKTNPEWTKARRFNDCLPVSDSRALCDQYSENSDSAYDQSEQRARQPPPPLPPQKQAHQEPREIRGERNKDKPLLRRKSDLPSDSGTVKALNEHKRTDEYLTTPPPDGNY
Protein: Large ribosomal subunit protein uL2A (60S ribosomal protein L2-A) (L5) (RP8) (YL6) (P0CX45)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL5B
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL6A
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL43A
- Ribosome biogenesis protein NOP53
- Large ribosomal subunit protein eL27A
- Large ribosomal subunit protein uL13A
Sequence:
MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGSQKTQD
Protein: Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] (O00533)
Organism: Homo sapiens (Human)
Function: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Contactin-6
- Ankyrin-1
- Neuropilin-1
- Heat shock cognate 71 kDa protein
- Contactin-associated protein-like 4
Sequence:
MEPLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPLRA
Protein: Ceramide synthase (EC 2.3.1.-) (Protein FAM57B) (TLC domain-containing protein 3B) (Q71RH2)
Organism: Homo sapiens (Human)
Function: Involved in ceramide synthesis.
Subcellular location: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q7TNV1}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TNV1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sphingosine-1-phosphate phosphatase 1
- Sphingosine kinase 2
- Serine palmitoyltransferase 2
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase 3
- Sphingomyelin phosphodiesterase
- Upstream-binding protein 1
- Ceramide synthase 2
- Ceramide synthase 6
- Long-chain-fatty-acid--CoA ligase 5
Sequence:
MLTPMVAGGVVFPGLFLLSKNTLQRLPQLRWEEADAVIVSARLVSSVQAIMASTAGYIVSTSCKHIIDDQHWLSSAYTQFAVPYFIYDIYAMFLCHWHKHQVKGHGGDDGAARAPGSTWAIARGYLHKEFLMVLHHAAMVLVCFPLSVVWRQGKGDFFLGCMLMAEVSTPFVCLGKILIQYKQQHTLLHKVNGALMLLSFLCCRVLLFPYLYWAYGRHAGLPLLAVPLAIPAHVNLGAALLLAPQLYWFFLICRGACRLFWPRSRPPPACQAQD
Protein: Quaternary amine transport ATP-binding protein (EC 7.6.2.9) (Q7AP69)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Subcellular location: Cell inner membrane {ECO:0000256|RuleBase:RU369116}; Peripheral membrane protein {ECO:0000256|RuleBase:RU369116}.
Interaction partners:
- OpuCB protein
- OpuCC protein
- Probable ergothioneine transporter EgtUBC
- OpuCD protein
- Quaternary amine transport ATP-binding protein
- Lmo1651 protein
- Lmo0608 protein
- Lmo0107 protein
- Lmo0137 protein
- Lmo0195 protein
Sequence:
MIRFDNVSKKYSDDKTAAVNNVTLDIKDGEFFVFIGPSGCGKTTTLKMINRLIPLTTGTIYINEKRISDYDIHELRWDIGYVLQQIALFPHMTIEENIAIVPELKKWSKEKIHDRITELLDSVGLDPESYRHRKPAELSGGEQQRVGVVRALAADPGIILMDEPFSALDPISRQRLQQDISALQKKIKKTIVFVTHDMQEALALGDRICVMQGGEIVQVATPQEIMKNPENDFVKDFLASGHAFNTPILEANFTVNDLIEADLFYSYQTSDGTLGISSTEPVENLVRRIAEEQSIPVTDEAGNYIGTVSNKHVMQFLARHLESSGELV
Protein: Serine palmitoyltransferase 1 (SPT 1) (SPT1) (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (O59682)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P25045, ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Serine palmitoyltransferase 2
- PIGF/3-ketodihydrosphingosine reductase fusion protein
- Uncharacterized protein C119.09c
- Serine/threonine-protein kinase tor1
- Serine/threonine-protein kinase tor2
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Tryptophan synthase
- Target of rapamycin complex subunit wat1
- Target of rapamycin complex 1 subunit mip1
- Sphingolipid delta
Sequence:
MSYSYPFFDDVYAYYNQTVTFFGKALDVLPGSPIVKRYIKSSYQNDPLRTFIEFLLLVFAAYYVLRKPRTSPDNNYVEFTEKEINELVDDWKPEPLVAELTDVEKLELKSIPVLESVHLHTKLIDGRPITNFASFNFLDLAENKHITECAVATLRECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERAIVYAQSFQTISSVIPAFSKRGDILVVDEACNFAIQKGIQISRTTIRYFKHNNMKDLERILQELEDDFVKHNRPLTRRFIITEGISENYGDMVDLTKIVALKKKYKYRLILDETWSFGTCGRTGKGLTEHFGVPPTDVEIIIGSLTTSLAGGGGFCAGSELMVEHQRLSGMAYIYSAALPASLAVAAYEAISILSRDGGSMLNDLRSKSALFHAKLSRNKFFETSSDIESPIIHLRFKDKDISHDKQVFLLEEIVELCIAEGFLIARAKRVESLERVKVQPSLRICISTGHSAEEIEKLALLIKEKTEIVFDKHKVINQV
Protein: Actin-related protein 3 (Protein DISTORTED TRICHOMES 1) (Q9SAF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. Involved in the control of cell morphogenesis in leaf epidermal pavement cells, root hairs, hypocotyls epidermal cells and trichomes, especially during rapid cell expansion. Regulates the directionality of cell expansion by regulating the actin organization, and thus the microtubules distribution and the fusion of small vacuoles.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2A
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2/3 complex subunit 5B
- Actin-related protein 2/3 complex subunit 5A
- At4g14145
- Protein NAP1
Sequence:
MDPTSRPAIVIDNGTGYTKMGFAGNVEPCFILPTVVAVNESFLNQSKSSSKATWQTQHNAGVAADLDFYIGDEALAKSRSSSTHNLHYPIEHGQVEDWDAMERYWQQCIFNYLRCDPEDHYFLLTESPLTPPESREYTGEILFETFNVPGLYIAVNSVLALAAGYTTSKCEMTGVVVDVGDGATHVVPVAEGYVIGSCIKSIPIAGKDVTLFIQQLMRERGENIPPEDSFDVARKVKEMYCYTCSDIVKEFNKHDKEPAKYIKQWKGVKPKTGAPYTCDVGYERFLGPEVFFNPEIYSNDFTTTLPAVIDKCIQSAPIDTRRALYKNIVLSGGSTMFKDFGRRLQRDLKKIVDARVLANNARTGGEITSQPVEVNVVSHPVQRFAVWFGGSVLSSTPEFFASCRTKEEYEEYGASICRTNPVFKGMY
Protein: Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Q9LF21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03012}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit K
Sequence:
MTTIVPTSEEDPYLAIVRFTSQLAWADAGPEVAEPEVSRLCKEAEESIINGKWLDLATLMVTSADLVSAKISEKDLECTYTIICNLVKNANSPEEVLEMVKAIAAKVIQQPNDKASLRLKILFNLYNLVDHPNARFQVYMKALELAVNGKVTEYIVPSFKKIDSFLKEWNIDIKDQRELFLAIAKVLRENKSFAKESLQFVTNYLATFSNEDTQVLSEAKEEAVRAVIEFVKAPSIFQCDLLDHPAVAQLEKDPNNAPVYQLLKIFLTQRLDAYMEFQNANSGFLQTYGLVEEDCVAKMRLLSLVDLASDDSGKIPYASIKNTLQVNDEEVELWVVKAITAKLVACKMDQMNQVVIVRQVSNLLLFRFICVNPKSHILVLHICSCISRCAEREFGQKQWQSLRTKLAAWRDNVRNVISTIESNKATEEGTQTSSAAQGLTVR
Protein: Thioredoxin domain-containing protein 5 homolog (Protein pretaporter) (Q9VYV3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells. Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation.
Subcellular location: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:19927123}. Cell surface {ECO:0000269|PubMed:19927123}. Note=Relocates from the endoplasmic reticulum to the cell surface during apoptosis. {ECO:0000269|PubMed:19927123}.
Interaction partners:
- Protein disulfide-isomerase
- Protein disulfide-isomerase A6 homolog
- Ero1-like protein
- Protein windbeutel
- IP08350p
- Protein draper
- Endoplasmic reticulum chaperone BiP
- Calreticulin
Sequence:
MLTRSILSVAVCGLLLSPLLPITRASQEEDTGKQDKQFTVELDPETFDTAIAGGNVFVKFFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWIEDGKKIEKYSGARDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQLTGEDEFDQAIAEGVAFIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQNEYEGSRSLPELQAYLKKFLGHDEL
Protein: Beaten path Ic (Beaten path Ic, isoform B) (Beaten path Ic, isoform C) (GH22661p) (Q9VJM4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH26014p
Sequence:
MAKTTIPGASTRHMQMANRWRTEKDVGSHGSQSGRSCICWISVVLLLILVPDFIEALKDVSVMIPQAVKRGSNALFTCNYDMENDTLYSVKWYKGKREFYRYTPKENPAMKVFAMTSGLNVERNLSNQSHVVLQSVPLNISGKFTCEISVEAPTFQTAMVSGEMEVVELPEEHTVVTGIQARYRIGDLVDGNCSIKYSKPAANLTWTINGIVVPPHHIKTYQTEKRENSTLESVTSAIHFMVTNQHFLKGQMRLKCTANIFDIFKEEMESVIEEDRPRIMASGRSYDINNYPLEEHTNGERGGFEDHNESYLTYYSADNTASGASTAAHEIFWQFWPSQLTKLPINRQLAGAWHWLCGGGGAAALLLFFLLQQGPLGHQIINCQYTKPATGKVQQQQRNSGSSSNIEVTASKAATSSASSVKCFYNCQMAMAMPTRSRDDDDDGGDAYIGSTSANATATATATADADAADVAAAGGVASCSIKRLSATLVGGVNAVRGVASGPDQRLLMTRRRERRQKKSQAMDAMMQSRWSAC
Protein: Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) (Q9NQT4)
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Interaction partners:
- Exosome complex component CSL4
- M-phase phosphoprotein 6
- Nuclear nucleic acid-binding protein C1D
- Exosome complex exonuclease RRP44
- Exosome complex component RRP45
- Exosome complex component 10
- Exosome complex component RRP40
- Exosome complex component RRP4
- Exosome complex component RRP42
- Exosome complex component RRP41
Sequence:
MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS