wanglab/gogpt-training-data huggingface dataset:
Protein: Iron sulfur cluster assembly protein 1, mitochondrial (Iron sulfur cluster scaffold protein 1) (Q03020)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase. Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:10468587, ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:15143178, ECO:0000269|PubMed:16823961}.
Interaction partners:
- Cysteine desulfurase, mitochondrial
- Frataxin homolog, mitochondrial
- J-type co-chaperone JAC1, mitochondrial
- Protein ISD11
- Adrenodoxin homolog, mitochondrial
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- NifU-like protein
- Iron-sulfur assembly protein 2
- Iron-sulfur assembly protein 1
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
Sequence:
MLPVITRFARPALMAIRPVNAMGVLRASSITKRLYHPKVIEHYTHPRNVGSLDKKLPNVGTGLVGAPACGDVMRLQIKVNDSTGVIEDVKFKTFGCGSAIASSSYMTELVQGMTLDDAAKIKNTEIAKELSLPPVKLHCSMLAEDAIKAAIKDYKSKRNTPTMLS
Protein: Uncharacterized fimbrial-like protein YadN (P37050)
Organism: Escherichia coli (strain K12)
Function: Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Subcellular location: Fimbrium {ECO:0000305}.
Interaction partners:
- Uncharacterized fimbrial-like protein YadK
- Outer membrane usher protein HtrE
- Uncharacterized fimbrial-like protein YadC
- Uncharacterized fimbrial-like protein YadM
- Uncharacterized fimbrial-like protein YgiL
- Uncharacterized fimbrial-like protein YadL
- Uncharacterized fimbrial-like protein YfcQ
- Uncharacterized protein YfcO
Sequence:
MSKKLGFALSGLMLAMVAGTASADMDGGQLNISGLVVDNTCETRVDGGNKDGLILLQTATVGEIDAGVLNDTVGAKAKPFSITVDCSKANPNPGSTAKMTFGSVFFGNSKGTLNNDMSINNPSDGVNIALHNIDGSTIKQVQINNPGDVYTKALDATTKSAVYDFKASYVRAVADQTATAGYVKTNTAYTITYQ
Protein: PRA1 family protein B3 (AtPRA1.B3) (Prenylated Rab acceptor 2) (Q9FLB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
Interaction partners:
- PRA1 family protein A2
- PRA1 family protein A3
- PRA1 family protein H
- Protein YIP
- Protein YIP4a
- PRA1 family protein A1
- Aspartic proteinase A1
- Ras-related protein RABA5c
Sequence:
MMANPPTLPISDHSGGGSQSQQPVSTPAFRTFLSRLSSSIRQSLSQRRPWLELVDRSAISRPESLTDAYSRIRRNLPYFKVNYVTIVSLVLALSLLSHPFSLLVLLCLFCAWIFLYLFRPSDQPLVVLGRTFSDRETLGVLVILTIVVVFLTSVGSLLTSALMIGFGIVCLHGAFRVPEDLFLDDQEPANTGLLSFLSGAATSAAVAAASTPASGRV
Protein: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (EC 3.1.3.95) (Myotubularin-related protein 2) (Phosphatidylinositol-3-phosphate phosphatase) (Q13614)
Organism: Homo sapiens (Human)
Function: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:15998640}. Early endosome membrane {ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}; Peripheral membrane protein {ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12668758}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2D1}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z2D1}; Peripheral membrane protein {ECO:0000305}. Note=Partly associated with membranes (PubMed:12668758, PubMed:15998640, PubMed:21372139). Localizes to vacuoles in hypo-osmotic conditions (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}.
Interaction partners:
- Myotubularin-related protein 5
- Myotubularin-related protein 13
- Myotubularin-related protein 12
- Polyphosphoinositide phosphatase
- Myotubularin-related protein 10
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Inositol polyphosphate-4-phosphatase type I A
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Inositol polyphosphate 4-phosphatase type II
Sequence:
MEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERASSPAQCVTPVQTVV
Protein: Gene 27 protein (ORF27) (Q98138)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MASSDILSVARTDDGSVCEVSLRGGRKKTTVYLPDTEPWVVETDAIKDAFLSDGIVDMARKLHRGALPSNSHNGLRMVLFCYCYLQNCVYLALFLCPLNPYLVTPSSIEFAEPVVAPEVLFPHPAEMSRGCDDAIFCKLPYTVPIINTTFGRIYPNSTREPDGRPTDYSMALRRAFAVMVNTSCAGVTLCRGETQTASRNHTEWENLLAMFSVIIYALDHNCHPEALSIASGIFDERDYGLFISQPRSVPSPTPCDVSWEDIYNGTYLARPGNCDPWPNLSTPPLILNFK
Protein: Myosin heavy chain 7B (F7F0L5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMDMNELGESACYLRQGYQEMMKVHTVPWDGKKRVWVPDEQDAYVEAEVKTEATGGRVTVETKDQKVLTVRETEMQPMNPPRFDLLEDMAMMTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTATVVAAYKGKRRSEAPPHIYAVADNAYNDMLRSKSHLPHQSGAGKTVNTKRVIQYFAIVAALGDGPGKKAVRLARLGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDSYLLEKSRVIFQLPGERGYHVYYQILSGKKPELQDMLLLSMNPYDYHFCSQGVTTVDNMNDGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDSFLVLHQLRCNGVLEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDDTFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFKAGLLGILEELRDQRLAKVLTLLQARSRGRLMRLEYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALATAEAKRQELEETQVSVTQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEAKVKELNERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVVRLTKEKKALQEAHQQALGDLQAEEDRVSALAKAKIRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQETVTDTTQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQLQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEETVLRHEATVAALRRKQADSAAELSEQVDSLQRIRQKLEKEKSELRMEVDDLGASVETLARGKASAEKLCRTYEDQLSEAKIKVEELQRQLTDASTQRGRLQTENGEGLGGLPQRTDRPARPFTRRGAGPEVGAGAKGALAHAVQALRHDCDLLREQHEEESEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQREARGLGTELFRLRHSHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEKSELQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQAGRDEEQRLAAELREQGQALERRAALLASELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEVDLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQTEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQASTNLAKYRKAQHELDDAEERADMAETQANKLRARSRDALGPKVRRSQG
Protein: GEO02508p1 (HDC08084) (Mitotic spindle organizing protein 1) (Q6ILY6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000256|ARBA:ARBA00004267}.
Interaction partners:
- Grip71
- Gamma-tubulin complex component 4 homolog
- Tubulin gamma-1 chain
- Grip163
- Gamma-tubulin complex component 2 homolog
- Gamma-tubulin complex component
- Gamma-tubulin complex component 3
- GEO02512p1
- Tubulin gamma-2 chain
- GEO10396p1
Sequence:
MSEQPTQHKSDDRFTILQTLSDVVDSGLSKEALKICIELVDNGVCGGALAHVIRTIREEIQDDEDKESDDSGESAASTDSTL
Protein: Immunoglobulin lambda constant 1 (A0A0G2JE99)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS
Protein: Cell division cycle 16 homolog (S. cerevisiae) (Q32PS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNLDRLRKRVRHYIDQQQYQSALFWADKIASLSHEDPQDIYWLAQCLYLTAQYHRASHALRSRKLDKLYGACQYLAARCHYAAKEYQQALDILDMEEAASKKLLDKNLKEENGSREIVKDWEMSPSSINSSICLLRGKIYDAMDNRPLATSSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKDFLDSLPLSQQCAEEEVELLHFLFENKLKKYNKPSEMVVPDIVNGLQDNLDVVVSLAERHYYNCDFKMCYSLTSMVMVKDPFHANCLPVHIGTLVELSKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLERTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNPKLAEHFFSQALSIAPEDPFVIHEVAVVAFQNGDYKTSEKLFLDAMEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYEQALEYHRQALVLIPQNASTYSAIGYVHSLKGDFESAIDYFHTALGLKRDDTFSVTMLGHCIEMYISDSDAYIGTDIKDKVRKTLNTPALMKMLNTSADGNESRAQPVEEVNVCIETPSFNADKQTDAFQRFLLECDMHESDMMLETSMSDTST
Protein: SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11) (O94991)
Organism: Homo sapiens (Human)
Function: Suppresses neurite outgrowth.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Disks large-associated protein 3
Sequence:
MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A2A124)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSRNIEWEHFEEREKGHRSPRGSGGSHSGSRGNGIVPSPAHSAHCSFYRTRTLQSLTSEKKAKKVRFYRNGDKYFKGLVYAVSGDRFRSFDALLMELTRSLSDNVNLPQGVRSIYTADGGKKITSLDDLVEGESYVCASNEPFRKVDYTKNVNPNWSVNVKTGASRSMPSLTATKNELRERESKDYIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGAVKRLYTLEGKQIICLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSGKASTAFITECQVIKSSYSARSAPPVRYSGSKSPGTGRRSKSPGSVNGAPNSQITTPKSAKSSSSSPTSPRSMRNFKFSCNKRMGVPVRLSVQIPTHHSSAGNVNGSSETPQHHNNSLSPEVNGNRNLAASTILDKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMLQGNEHSSR
Protein: Segregation and condensation protein A (Q9EUQ7)
Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Function: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
Interaction partners:
- Segregation and condensation protein B
- Chromosome partition protein Smc
- Aspartate aminotransferase
- Chromosome segregation protein
- dITP/XTP pyrophosphatase
- Glutamate racemase
- Tyrosine recombinase XerD-like
- Pseudouridine synthase
- Phosphoesterase
- CBS domain-containing protein
Sequence:
MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVSTLQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLLGEHLEAKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHTTILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEVITLFLATLELIKTQELILVQEESFGDIYLMEKKEESQVPQS
Protein: Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom metalloproteinase (SVMP) (EC 3.4.24.-); Disintegrin bothrasperin] (Q072L5)
Organism: Bothrops asper (Terciopelo)
Function: Impairs hemostasis in the envenomed animal.
Subcellular location: Secreted {ECO:0000269|PubMed:25457103}.
Interaction partners:
Sequence:
MIEVLLVTICLAVSPYQGSSIILESGNVNDYEVVYPRKVTELPKGAVQPKYEDAMQYEFKVNGEPVVLHLEKNKGLFSEDYSETHYSPDGRKIITYPSFEDHCYYHGRIENDADSTASISACNGLKGHFKIQGETYLIEPLKLSDSEAHAVYKYENVEKEDEAPKMCGVTETNWESYEPIKKASQSNLTPEQQRFSPRYIELAVVADHGIFTKYNSNLNTIRTRVHEMLNTVNGFYRSVNVTASLASLEVWSKKDLIKVEKDSSKTLTSFGEWRERDLLPRISHDHAQLLTTIVFDNYVIGITEFGKMCDPKLSVGVVRDHSEINLQVAVAMAHELGHNLGMYHDGNQCHCDAASCIMADTLREVLSYEFSDCSQNQYETYLTKHNPQCILNEPLLIVSGNELLEAGEECDCDAPENPCCDAATCKLRPGAQCAEGLCCDQCRFKGAGKICRRARGDNPDDRCTGQSADCPRNRFHA
Protein: 4-coumarate--CoA ligase 2 (4CL 2) (EC 6.2.1.12) (4-coumarate--CoA ligase isoform 2) (At4CL2) (4-coumaroyl-CoA synthase 2) (Caffeate--CoA ligase) (EC 6.2.1.-) (Q9S725)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioesters (By similarity).
Interaction partners:
- Trans-cinnamate 4-monooxygenase
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- Cytochrome P450 84A1
- Phenylalanine ammonia-lyase 1
- Flavone 3'-O-methyltransferase 1
- Phenylalanine ammonia-lyase 4
- F5F19.5 protein
- Phenylalanine ammonia-lyase 2
- Phenylalanine ammonia-lyase 3
Sequence:
MTTQDVIVNDQNDQKQCSNDVIFRSRLPDIYIPNHLPLHDYIFENISEFAAKPCLINGPTGEVYTYADVHVTSRKLAAGLHNLGVKQHDVVMILLPNSPEVVLTFLAASFIGAITTSANPFFTPAEISKQAKASAAKLIVTQSRYVDKIKNLQNDGVLIVTTDSDAIPENCLRFSELTQSEEPRVDSIPEKISPEDVVALPFSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFNRDDVILCVLPMFHIYALNSIMLCSLRVGATILIMPKFEITLLLEQIQRCKVTVAMVVPPIVLAIAKSPETEKYDLSSVRMVKSGAAPLGKELEDAISAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKILDPDTGDSLPRNKPGEICIRGNQIMKGYLNDPLATASTIDKDGWLHTGDVGFIDDDDELFIVDRLKELIKYKGFQVAPAELESLLIGHPEINDVAVVAMKEEDAGEVPVAFVVRSKDSNISEDEIKQFVSKQVVFYKRINKVFFTDSIPKAPSGKILRKDLRARLANGLMN
Protein: Phospholipid scramblase (Q9XV36)
Organism: Caenorhabditis elegans
Interaction partners:
- Cell death abnormality protein 8
Sequence:
MNKQPGEQPVSCATSTGKSEKERQKDEPPRSRAEAGMMRGGGRLPQPRDTPMEVPNMIAAMPIQMTGFVDLAPHTILDVLAQTTSLMIVQCLEPLEIFTGIETPNRYVVHDMYCRPLLYCMERSSFFARQHQGSQRNFAMQCMDIFGAPVMNCFRSRPCCSCDDFLATEFLGQRIGMMKRECCDDNFHLVGTGSNEPLLVRSPGCACCGGTQVFPVMTYNGAKIGEIVRLYPGFMQEWYTDADTYIVHFPPDLPPILKILLISSTFLIDYTFFENRGGNQRGGYGHGGYGYY
Protein: Serine/threonine protein phosphatase 2A regulatory subunit (B7Z0L7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVDFLTNQNGVITEVIYPEAINMFAVNLFRTLPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQQVESLAKTNPEWTKARRFNDCLPVSDSRALCDQYSENSDSAYDQSEQRARQPPPPLPPQKQAHQEPREVRQALATLTTLNNY
Protein: WW domain-containing protein (Q95PX7)
Organism: Caenorhabditis elegans
Interaction partners:
- Forkhead box protein O
- RNA helicase
- Microfibrillar-associated protein 1
- Probable small nuclear ribonucleoprotein Sm D1
- Probable U2 small nuclear ribonucleoprotein A'
- Ribonuclease kappa
- 14-3-3-like protein 1
- Ribonuclease kappa
- FERM domain-containing protein
- Splicing factor 3B subunit 1 domain-containing protein
Sequence:
MSHENQENYDDYNGDHDNKYDQQYDESSRGDDFGGYGRGGSSSGRGRGFNGPPGGAGSFFGVPPAARGRGGPGMAPPGFAGRGRGFATPGMSSGFAPRGRGMPPGRGGYMPPYRGGYGVAPNGGPGAYGGPYNGGPGAYGAQAPGPNPQDQEQRLKRLSGCEEGQELWVETETAEGKKYFYHPVNRNTIWERPQNAKIVTQPELAQLIHRATEEEKNREERMPHGQIPQNPDDAWNEFNAPDGRKYYFNSITQENTWEKPKALIDQENGGGASPEPVQSAAIAEAQAKAQAALAAFMAQQKTSSNGGGGMPLSKAQASGAAAAAAVNAEAAKKKDSTRPISSTPVSGTPWCVVWTGDDKVFFYNPSTKCSVWERPPDTYGREDVDKLVQNPPSPKAEEENNQSKKESESESESDEDGPPKAKKSRAEKKKEALIAAQKKEKERPRQMLQKPVDPAIEAEMQAAKEREKVPLEERLKQFKEMLEEKNVSTSSTFEKELSKIVFDKRYLSLGATERRACFDAFCREKIESEKAERRKRVKEAKEEFQKLLAECELNGRSSYSSFTSKFGKDPRYKAVERNRDREDAFNDFVGELHKKEKDEKRAKKEKLKAAFVKLLEEQTGLTRKSKWSTTKKTLEDEERYIALDSSSTRESLFREFVANLGDETASDIEEEQEREKRLAAQTAIANRQKEVEAELGNQLRERTKESEKQKMGEHEDTYRNLLIDLIKSTENSWHEARRILRKDERYANCDMLDKTRKESLFDDHIKSLERKRREAFFQVLDNHEKITPMMRWRDAKKIIQDEEETFVKIASNSERKVERDFRDWQERRHDHLTDEFKEMLSETKIITHKSKKLMEEGEQHMDILSVLENDKRWVRMTAMSASERDRMLEDHIENLGRKGTPPPPTQQERDRRKQ
Protein: Protein SPMIP9 (Sperm microtubule inner protein 9) (Testis-expressed sequence 37 protein) (Testis-specific conserved protein of 21 kDa) (Q96LM6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9DAG4}. Cytoplasm {ECO:0000269|PubMed:26168773}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9DAG4}. Note=Present in the germ cell lineage at all stages (PubMed:26168773). {ECO:0000269|PubMed:26168773}.
Interaction partners:
Sequence:
MAGVKYPGQDPVDLDIYQSSHMVDYQPYRKHKYSRVTPQEQAKLDAQLRDKEFYRPIPNPNPKLTDGYPAFKRPHMTAKDLGLPGFFPSQEHEATREDERKFTSTCHFTYPASHDLHLAQGDPNQVLQSADFPCLVDPKHQPAAEMAKGYLLLPGCPCLHCHIVKVPILNRWGPLMPFYQ
Protein: PHD-type domain-containing protein (Q3UPK1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
SGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGAGGGSSGGGGGGSSSASGGGGGTGGGSGNSFLSGRRSRSASPSTQPEKHPTHHEKGQKKSRKDKERLKQKHKKRPESPPSVLAPPAVPTADKVSSATSSSHHEASTQETSESSRDSKGRKSSSHSLSHKDKKLGTGKGSSLQSSPDFAAFPKLEQPEEDKYPKPADPTPPAPPSPTAPEPPKADLFEQKVVFSGFGPIMRFTTTASSSSRARAPSPGDYKSPHITGAGASAGTHKRMPALSATLGPAEEAPETTLKEKKHKASKRSRHGPGRPKGSRGKEGASGPTASLPAAQLAGFTATAASPFSGGSLVSAGLGGLASRTFGPSGSLPSLSLESSLLGAGIYTSNKDPISHGGGMLRAVCSTPLSSSLLGPTGTSALPRLSRSPFTSTLASSSASISTTQVFSLAGSTFSLPSSHIFGTPMGTVNPLLTQAESSHTEPDLEDCSFRCHGTSPQESLSSMSPISSLPALFDQTSAPCAGGQLDSTAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQVLNVQLSVPFPALPAALPATNGPIPGPYGLLPQAGSSDSLSVSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPGATGLGAMPMAEGLLGGLAGSGSLPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQMQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGSNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLPGADASGNGPKGGTADKGASTSQEKG
Protein: ParB/Sulfiredoxin domain-containing protein (Q9I1Y9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Phosphoadenosine phosphosulphate reductase domain-containing protein
Sequence:
MAQTKTLTERAEALFGELHGLPLAERIEAINRIRRLLHAHSPFAEEPVDCVQWVRAERVAGNDYNPNTVAPPEMRLLRLSIESDGFTQPIVAYPQADGRYEVVDGFHRLRVGSAKGALRQRLHGYLPIAAIRAGREGDSERIAATIRHNRARGVHGVLPMTAIVVTLLKAGWSEADVARELGMDNDEVLRFKQVSGLPELFREHVYSRSWE
Protein: Acidic leucine-rich nuclear phosphoprotein 32 family member (Q53F35)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369103}.
Interaction partners:
Sequence:
MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLEEDEDEDEDEEEEEGGKGEKRKRETDDEGEDD
Protein: CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase) (Q9LTW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alkaline-phosphatase-like family protein
- GMP synthase
- Nucleoside diphosphate kinase 1
- Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
- Nucleoside diphosphate kinase II, chloroplastic
- Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
- Aspartate--tRNA ligase, chloroplastic/mitochondrial
- Delta-1-pyrroline-5-carboxylate synthase B
- Protein trichome birefringence-like 21
- UMP kinase
Sequence:
MKYVLVTGGVVSGLGKGVTASSIGLLLQACGLRVTSIKIDPYLNTDAGTMSPFEHGEVFVLDDGGEVDLDLGNYERFLDSTLTRDNNITTGKIYQSVIDKERKGDYLGRTVQVVPHVTDAIQEWIERVANVPVDGKEGPPDVCVIELGGTIGDIESMPFIEALGQFSYKVGPGNFCLVHVSLVPVLSVVGEQKTKPTQHSVRGLRSLGLTPNILACRSTKALEENVKTKLSQFCHVPEVNIVTLYDVPNIWHVPLLLRDQKAHEAILRELNLSNAIKPDLTEWTARTKIYDTLQDPVRIAMVGKYTGLTDSYLSVLKALLHASVACHKKLVIEWVAASDLEEITAQETPDVHKAAWDLLKGADGILVPGGFGDRGVQGKILATKYARENQVPFLGICLGMQLAVVEFARSILGFHDANSTEFEPETSSPCIIFMPEGSTTHMGGTMRLGSRKTYFQVADCKSAKLYGNAKFVDERHRHRYEVNPDMISEIEKAGLSFVGKDETGRRMEIVELPSHPYFVGAQFHPEFKSRPGKPSALFLGLIAAASGCLESVLQTGGKVNIVSKNGVANGSAMGKVHQNGNVYSNGNGLHH
Protein: DNA topoisomerase medium subunit (EC 5.6.2.2) (DNA topoisomerase 51-kDa subunit) (Protein Gp52) (P07065)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Medium subunit of the DNA topoisomerase that untwists superhelical DNA. Controls topological states of double-stranded DNA by transient breakage and subsequent rejoining of DNA strands.
Interaction partners:
Sequence:
MQLNNRDLKSIIDNEALAYAMYTVENRAIPNMIDGFKPVQRFVIARALDLARGNKDKFHKLASIAGGVADLGYHHGENSAQDAGALMANTWNNNFPLLDGQGNFGSRTVQKAAASRYIFARVSKNFYNVYKDTEYAPVHQDKEHIPPAFYLPIIPTVLLNGVSGIATGYATYILPHSVSSVKKAVLQALQGKKVTKPKVEFPEFRGEVVEIDGQYEIRGTYKFTSRTQMHITEIPYKYDRETYVSKILDPLENKGFITWDDACGEHGFGFKVKFRKEYSLSDNEEERHAKIMKDFGLIERRSQNITVINEKGKLQVYDNVVDLIKDFVEVRKTYVQKRIDNKIKETESAFRLAFAKAHFIKKVISGEIVVQGKTRKELTEELSKIDMYSSYVDKLVGMNIFHMTSDEAKKLAEEAKAKKEENEYWKTTDVVTEYTKDLEEIK
Protein: Transducer of ERBB2, isoform A (Transducer of ERBB2, isoform F) (Q9VXJ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- poly
Sequence:
MHIEIQVALNFVISYLYNKLPRRRVNIFGEELEKALRDKFQDHWYPEKPFKGSAYRCLKTGDPIDSVLERAARESGVPIGDILENLPNELSVWIDPGEVSFRIGEKGAVKILYTENNENHEDSHSADREVTKMFNPEAQCFRPIDAVNTTMNNMSLSPKGHHQSGSSPHSAASSSPTYKGSPNRTISGSCSSVSGAGSGTGSGSRSGSNHAPGPGTAPGPVPGNGATANAAAAAFMQRGAQAPLTFTTATFAQTKFGSTKLKTSSKRTNSSSAYRMSPTEFSNYIKQRAMQQQMHHGHAVVPSAGSSVSAAYGGMDAVSPARSLSPNPLSLAGNQNQSVSGSSADSYYYPNMPINMYPQYGNPRCLFESHFSADVSSMGLYVSGTAGAAVTAVGSVGANKYSTYLEPCYYGNGHANTQQHSQQQTRVGMDRPNSSESCFGLNVDCGSVVLEDSSSSSSAAAAAVAVTIAGDSSAENSPLSTPTLAAVNVGKATSPPTNSTNNSSSHPIQQQEQPSSSSGNGNGNANANANGNNGNNSNSNTKLIDGISSFYGTGSSYQQLLVAN