wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome B5 isoform D (AtCb5-D) (Cytochrome b5 isoform B) (AtCb5-B) (Q9ZWT2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases, including fatty acid desaturases.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17322552, ECO:0000269|PubMed:22773744}; Single-pass membrane protein {ECO:0000269|PubMed:17322552, ECO:0000269|PubMed:22773744}.
Interaction partners:
- NADH--cytochrome b5 reductase 1
- NADH-cytochrome b5 reductase-like protein
- Dihydroceramide fatty acyl 2-hydroxylase FAH1
- Very-long-chain aldehyde decarbonylase CER1
- Bax inhibitor 1
- Dihydroceramide fatty acyl 2-hydroxylase FAH2
- Probable lysophospholipase BODYGUARD 1
- Probable steroid-binding protein 3
- Very-long-chain aldehyde decarbonylase CER3
- Delta
Sequence:
MGGDGKVFTLSEVSQHSSAKDCWIVIDGKVYDVTKFLDDHPGGDEVILTSTGKDATDDFEDVGHSSTAKAMLDEYYVGDIDTATVPVKAKFVPPTSTKAVATQDKSSDFVIKLLQFLVPLLILGLAFGIRYYTKTKAPSS
Protein: G protein-coupled receptor associated sorting protein 3 (Protein BHLHb9) (bHLHb9) (Transcription regulator of 60 kDa) (p60TRP) (Q6PI77)
Organism: Homo sapiens (Human)
Function: Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15034937}. Nucleus {ECO:0000269|PubMed:15034937}. Note=Mainly cytoplasmic, and nuclear at lower level.
Interaction partners:
Sequence:
MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFWAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKPQPVYEINEKNRPKDWSEVTIWPNAPAVTPAVLGFRSQAPSEASPPSYIVLASAEENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFACPCKMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIESLLSFPSPEMRKKTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALAALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM
Protein: Protein CASP (Q9LS42)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in intra-Golgi transport.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16028120}; Single-pass type IV membrane protein {ECO:0000269|PubMed:16028120}.
Interaction partners:
- CASP-like protein 4C1
- Golgin candidate 6
- Inositol diphosphatase DSP1
- Inositol diphosphatase DSP2
- DNA cross-link repair protein SNM1
- Cleavage and polyadenylation specificity factor subunit 3-I
- ARM repeat superfamily protein
- Inositol diphosphatase DSP3
- Golgin candidate 1
Sequence:
MEVSQDGSERDKTPPPSSSSSSSSPIPVVTNFWKEFDLEKEKSLLDEQGLRIAENQENSQKNRRKLAESTRDFKKASPENKLSMFNSLLKGYQEEVDNITKRAKFGENAFLNIYQKLYEAPDPFPALASIAEQDRKLSEVESENRKMKVELEEFRTEATHLKNQQATIRRLEERNRQLEQQMEEKIKEVVEIKQRNLAEENQKTMELLKDREQALQDQLRQAKDSVSTMQKLHELAQNQLFELRAQSDEETAGKQSEVSLLMDEVERAQTRLLTLEREKGHLRSQLQTANEDTDNKKSDNIDSNSMLENSLTAKEKIISELNMEIHNVETALANERESHVAEIKKLNSLLNKKDTIIEEMKKELQERPSAKLVDDLRKKVKILQAVGYNSIEAEDWDAATTGEEMSKMESLLLDKNRKMEHEVTQLKVQLSEKASLLEKAEAKGEELTAKVNEQQRLIQKLEDDILKGYGSKERKGALFDEWEFSEAGVAEQSEPMDQKHVPSEQDQSSMLKVICSQRDRFRARLRETEEEIRRLKEKIGFLTDELEKTKADNVKLYGKIRYVQDYNHDKVVSRGSKKYVEDLESGFSSDVESKYKKIYEDDINPFAAFSKKEREQRIKDLGIRDRITLSSGRFLLGNKYARTFAFFYTIGLHVLVFTCLYRMSAYSYLSHGAEETLMTEATTNLPHGL
Protein: FUS RNA binding protein (H3BPE7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY
Protein: Transcription factor cicD (Cichorine biosynthesis cluster protein D) (A0A1U8QIH0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
Sequence:
MVGSRHPDQCAKRWHHSLDPNVKRGPWTMEEDSSLLEAVQKIGRDWKEIGRELFPSRSTTDIKNRYVILSRRRGPSPAIPENCSSIDIETHSSSLADSKPPIPAELLTPEVDFSIANTPCELDSSNLAPDTLSINMTLPSDLPSYLSLPLPDTAETDHALDESSTAWEIPDWTAFDNQCLFTPGASELEGSFTSRNHEEPPQPLPVPDIPGPSTLVLEDLRPETVNLVIDTLLRTNSKFGMRMYNTGS
Protein: Sulfate anion transporter 1 (SAT-1) (Solute carrier family 26 member 1) (Q9H2B4)
Organism: Homo sapiens (Human)
Function: Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P58735}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P45380}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 13 member 1
Sequence:
MDESPEPLQQGRGPVPVRRQRPAPRGLREMLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPAQGEDLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHRELEATDAHL
Protein: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (Phosphorylated CTD-interacting factor 1) (P59114)
Organism: Mus musculus (Mouse)
Function: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H4Z3}.
Interaction partners:
Sequence:
MANENHGSPREGASLLSHSPGTSSQSQPCSPKPVRLVQDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSSLVETPPVENKSRKRQLSEEQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPTLKIWGSSTEDKQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPDVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAVLKENNIPEEVEASELEPRLVYCYPVRLAVSAPPMPSVEMHVENSVVCIRYKGEMVKVSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFETLHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSAEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNGPGFAKWGPTPERLQELTAAYKQSGRSHGSSSSSSSSSSSSEAKDRDSGREQGPSREPHPT
Protein: tRNA-intron lyase (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (C9J7Z4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQDESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKSGGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGSQHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEELVQRNRLICRRNPYRIFEYLQLSLEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIIELVDDHFEGSLRRPLSWKSLAALSRVSVNVSKELMLCYLIKPSTMTDKEMESPECMKRIKVQSRSVVQAGVQCCDLGSLQPLPAGFKRFSCLSLLSSWDYRHAPPHTANFCIFSRDGVSLCWPGWSGTPDLK
Protein: T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (O94501)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable T-complex protein 1 subunit eta
- T-complex protein 1 subunit gamma
- Probable T-complex protein 1 subunit theta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit epsilon
- Probable T-complex protein 1 subunit beta
- T-complex protein 1 subunit delta
- Phosducin-like protein C2A9.09
- Transport protein particle subunit bet3
- Heat shock protein 60, mitochondrial
Sequence:
MFQAPRESTLFLSGEKISGEDVRNQNVLATTAIANVVKSSLGPVGLDKMLVDDIGDVTVTNDGATILSLLDVEHPAGKVLVELAQQQDKEVGDGTTSVVIIAAELLRRANELVKNKIHPTTIITGYRLAIREAVKFMTDVLSCSVDSLGKESLINVAKTSMSSKIIGNDSDFFSTMAVDAMLSVKTSNSKGETRYPVKAVNILKAHGKSSRESVLVKGYALNCTIASQAMKTRVQNAKIAVLDMDLQKTKMALGVHVTIDDPDQLEKIREREVMITLERVKKILNAGANVILTTKGIDDLCLKSIIEAGAMAVRRCKKEDLRRIAKASGATLLSSLSNLEGEETFESSYLGSAEEVVQEKFSDDECILVKGTKAYSSASIVLRGPNEYSLDEMERSMHDSLSVVKRTLESGKVVPGGGAVETALSIYLENFATSLGSREQLAIAEFAQALLIIPRTLAVNAAKDSTELTAKLRAYHAASQNAEVTDVKKRGYKNYGLDLLNGVIRDNVKAGVLEPSMSKLKSLKSAVEACIAILRIDTSIKLDPERQPEDPHAGLH
Protein: Dihydroxyacetonephosphate acyltransferase (EC 2.3.1.42) (Q4Q396)
Organism: Leishmania major
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- Alkylglycerone-phosphate synthase
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase-like protein
- Glycerol-3-phosphate acyl transferase
- Putative lipin
- Putative choline/ethanolamine phosphotransferase
- Diacylglycerol kinase
- Putative phosphatidic acid phosphatase
- Dihydroxyacetone kinase 1-like protein
Sequence:
MSFPPPRLALPEECKQVVLVAPIDGFTAACACAIATSPLVPLNCRVLVDGIAVKSSSPSSGNDSPHMACSSAESAATARDFMNTVQRVEAKLRASRATRRDVSVTHITQFYYGGVSPKAEEIGPMLHRIHLLGSGALGETNFTASSTDVTAGSGGSSGVPRVADSVFVLVLSAQSLSPDTESGLKAYDILLRRLWSAAGPSQAAETASQQTRVRGSLVILADDVYRTAACAMLSSIAKEVATAVDWVVLLAYAYAMDPPALEFGATEVAVQAASGISLGGTLPVLCAANALGVLRHFPVSRGEPATITPVDVALNAALLGYVWLCHGELPECVECAAEMQYCGLSPAPSHAAAAAETATAMPTQPAQCVTRHRMGSFAVAESRKPGEVSLVWGMVGEYLMSYYGRFADQISAAFPVAGVLTQAPILQFPFSVADWVNFGPEPRAAAYALEGWRAYQQRQRLMEEKVGNAEAAQALKAYVAQMDSVVRYIERTARAAAARDKISAAFAASRRRTASSSFSVPPYRLDDFNVALYHSLLRRLTSHHTLMPYHQCVALVEVDWEAYVSVIARAVLEHLARCVLRSSSGLQHVRSRFHALPVADSANIGSVVRSPPVVSAPDELAPASAAVPSSTKPEAAASAAEAPFAFPEPRRYFTNDFVYRGAERIPPFPSLLHKYFDCFVFLHRVGMTANGWRGDMTPGMTPQVLTSIIAQPNIQRLMTALAAKDGASKKDVEARAKRLLLECGDALNHVHCRTLGLMIRTIFHSIYGRVDVNNGSYERLHRYFAMPRVAVVFAPLHRSYIDFLILSEVLALMRLPLPHIVAGENFLSMGVLATLMRGSGALFMRRSFRDDPLYAALLKEYVRHLVRARRPLEFFIEGARSRTGKTMAPKLGLLKFVCDTFYEPGQQELDDVLIVPVSLSYDEVLEATTHAKELLGVPKPKENPTNMLKARSLLERMHGNIHIHVGEPVSLRSLKQHPRQCPLPLQPKDEQLRDPAAPAAATTSVCKTLDTTPSIAKGSSITPIPLLGTVAWHLVYKLQRNTVITPASMVAAVVECLGPYYCTATTMLKEGIDTTAAAPTAAAAMPLEKVHQGVEWLRGRLRERGAQLSAEASKLNPAGVVTLALTNLYRYIHITDEMSGVTYHPDNVVTRLAVNISTNQLIHVCMNEALVAVVAQAFGFVTTPHRPPSGADGAMLCGVRSVKADVLSNQTQLLQRLLSAEFPNYAEAAPVSFASWLECTVSQLQQCVEEHTVSSQLSGADTHGGTIVHLPVTQYYYFLLQLICPHVEALYTVLAAASALLAAYPGKPFGAAEVVTATQRACYILYAERKLRYIVAANKETLQHYYESLIALSLLQIKRVPITTTPGQSKVNGGVVAYTVGLLGQEAALARLEVLSTQIKALWWHPSAAEGVTIDKAAIQERVLAVYRELTQPSKM
Protein: Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) (Q9USP0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit alpha
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 2 subunit gamma
- Probable eukaryotic translation initiation factor 2 subunit beta
- eIF-2-alpha kinase GCN2
- eIF-2-alpha kinase activator gcn1
- Guanine nucleotide exchange factor MSS4 homolog
Sequence:
MVESDSSGIVRHSQGEFDIVQVYKKFLQDDPEITMPVAAIEALVQLLSRSQAKTISEFMDILQNGSNTLKEGVQNNISLSAGCDIFQRFVTRSLHDVGDFEQCKRHLVENGKLFIQRARACRQRIAHLGYPLIRDGSVILTHGFSRGVAAVLLAAAKRHVRFKVFVTESRPSGSGCLMTRTLKNACIPTCMVLDSAVSFTMNRVDLVLVGAEGVVENGGLINQIGTFQLAVFAKHAHKPFYAVAESHKFVRMFPLSQYDIPFSRPILEFDDPSPETVHPEPEPIPTPSDAIHNELIMNEEQIRNNPTLDVTPPEFVSGLITDLGIIDSKSGVSEELIKLYL
Protein: Pyr_redox_2 domain-containing protein (Q9U229)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Endonuclease G, mitochondrial
- Phospholipid scramblase
- sulfite oxidase
- 2Fe-2S ferredoxin-type domain-containing protein
- Cell death protein 3
- Large ribosomal subunit protein mL44
Sequence:
MLLRAVGRQMTSVIFRQQTAVRSIAMSRVALGGGGHHHEPTPVYIPKPGSLDWTFFSRSHTKSAHEFEPYKPEIGAFIGAVAFIGLTLIAVVIKTDVFKKEDSHGHGHGHAKHSKKHEEKHEQKHEEKEHAEPEKKEEAKPEKPAEPKEPEPAQKQAEQPEQAEEKQETKDAEPKEQVDDRQTEEAVHARRAPAAAEEPAPSTSKADAVEEKRSEQQSMKPSESTEENTTTTSADGLLHCEYVIIGSGTAAYYASLSIRAKQAEAKVLMIGEEPELPYNRPPLSKELWWYGDETSATKLAYTPLSGKKRDIFYEVDGFFVSPEDLPKAVHGGVALLRGRKAVKICEEDKKVILEDGTTIGYDKLLIATGVRPKKEQVFEEASEEAKQKITYFHYPADFKRVERGLADKSVQKVTIIGNGLLASELSYSIKRKYGENVEVHQVFEEKYPAEDILPEHIAQKSIEAIRKGGVDVRAEQKVEGVRKCCKNVVLKLSDGSELRTDLVVVATGEEPNSEIIEASGLKIDEKLGGVRADKCLKVGENVWAAGAIATFEDGVLGARRVSSWENAQISGRLAGENMATAAADGKSEGKAFWYQPSFFTKFAPHLHINAIGKCDSSLETVSVHAEPDKDTPLEKAVVFYKSKEDGSIVGVLLLNVFGPSLDVARRIIDDRKKVDEYKEIAKLFPLYDPVKSDEDDAKSA
Protein: Pectin lyase-like superfamily protein (F4IA77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Alpha-1,3/1,6-mannosyltransferase ALG2
- RING-H2 finger protein ATL80
- Alpha/beta-Hydrolases superfamily protein
- Probable protein phosphatase 2C 61
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- At1g04210
- Cysteine-rich repeat secretory protein 59
- non-specific serine/threonine protein kinase
- Cysteine-rich repeat secretory protein 29
Sequence:
MVSTISGFSLILFIAAVASSISAAPSAALVGRKVFDVRSYGARGDGKTDNTMAFTKAWKDACQWKGLPRVYIPFGTFYLGAVAFTGPCKSRISFIIKGTLLAPKDPNAIKQDSWIIFRYVDYLTVSGGGILDGQGSYSWPLNNCRQTHNCRALPMNMGFQFVRFSRLTRIKSINSKMGHLNFFSVQHFDITRVNIKAPGDSPNTDGIKIGSSNHMKIHHVDIATGDDCIAILSGTFNLDINKVNCGPGHGISVGSLGKFKGEKSVQGLIVRNSIFNGTSNGVRIKTWPSPGEPNLVSNFLFKNLQMIDVQSPINIDQRYCPNPPCSFQSFSKIQIRDVKFQNIWGTSTAKEAVKLQCSKNVPCKNVQLFNINIVHRGRDGPATSVCENVGGWIGGKISPPSCIR
Protein: Mitochondrial import inner membrane translocase subunit Tim23 (O14925)
Organism: Homo sapiens (Human)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit Tim17-B
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit Tim13
- Mitochondrial import inner membrane translocase subunit Tim10
- Stress-70 protein, mitochondrial
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import inner membrane translocase subunit Tim8 A
Sequence:
MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKGSLLQQSL
Protein: Short-wave-sensitive opsin 1 (S opsin) (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP) (Short wavelength-sensitive cone opsin) (P51491)
Organism: Mus musculus (Mouse)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P03999}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000269|PubMed:21219924}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:21219924}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P03999}.
Interaction partners:
- Arrestin-C
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Cone-rod homeobox protein
- Medium-wave-sensitive opsin 1
- Recoverin
- Photoreceptor-specific nuclear receptor
- RPE-retinal G protein-coupled receptor
- Guanine nucleotide-binding protein G
Sequence:
MSGEDDFYLFQNISSVGPWDGPQYHLAPVWAFRLQAAFMGFVFFVGTPLNAIVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYVVICKPFGSIRFNSKHALMVVLATWIIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIIPLSLICFSYSQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMADESDVSGSQKTEVSTVSSSKVGPH
Protein: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2 homolog) (Cap2 2'O-ribose methyltransferase 2 homolog) (MTr2) (FtsJ methyltransferase domain-containing protein 1 homolog) (Protein Adrift) (Q9UAS6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity). Regulates expression of tracheal genes required for pathfinding on the segmental nerve.
Subcellular location: Nucleus {ECO:0000269|PubMed:10068643}.
Interaction partners:
- mRNA cap guanine-N
Sequence:
MSFRSSPQGKPHPMTDYQSIRPSEVEQLFEKKFHYQKPKGNKSWQLPPPDQALFSEFYQFEALQGLREQLNAVKSKLNDYGVQEWSAHTNRRDPSGEVSWRLKNDTKAEFVTVAWCKLFECLHRYPLVTKPAVNSMHLCEAPGAFIASLNHYLHSKYEKDEIKWRWRSTTLNPYYEGNAINQMISDDRFIVHTLDNWFFHKDLTGNLLDVANIDHLVERCEVEFQGQVDLVTADGSIDCAAQPDCQEEIVVRLFFAEVLSALRILSSGGNFLVKMFTLFEACSVSLLYTLNCIFEEVHIFKPATSKRGNSEVYVICLNYNKDHPDLPRLLEEIKSKLAQPNDTLVMPLFAKFQIPHDFLMQHEIACRMYMKLQTDAIEGSIYAYESNDRHYLRHLHHLRSLVANTYYSLYKVKPLEDSLCIVDKEATSKALGFQVPVYGGSYTERESLKHGDLLKQIYCLRREFNQLEKCLNNRTPYSYVKNRTAPLNLHISRGAPVQSLQSSMFASEPILILRLRILDTFELDPVWQSAPKCQLESKTLCYLPPTEDEAFHTAQQRFFIDLLEEVKKLKPDSIVFHKFLFLTHYAASLLLFLIESVYQDCCFNSNQAQTLTLSKLKDTANSALEQVLELLKDEQAGAIHSLLDIKELQKNQFSKALIQHNNSIVMTCFRSMLGEESFPMPVAPTSNSDVGSIQESAAVF
Protein: Oligopeptide/dipeptide uptake family ABC transporter, ATP-binding protein (Q5LMM9)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004417}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004417}.
Interaction partners:
- Oligopeptide/dipeptide uptake family ABC transporter, permease protein
- Oligopeptide/dipeptide uptake family ABC transporter, permease protein
- Oligopeptide/dipeptide uptake family ABC transporter, periplasmic substrate-binding protein
- Peptide/opine/nickel uptake family ABC transporter, permease protein
- N-acetyltaurine ABC transporter, permease protein
- Oligopeptide ABC transporter, permease protein
- Dipeptide ABC transporter, permease protein
- Peptide/opine/nickel uptake family ABC transporter, permease protein
- Oligopeptide/dipeptide ABC transporter, permease protein
- Oligopeptide/dipeptide ABC transporter, permease protein
Sequence:
MSALLEVKGLNVSFRQDGRISQAVRGVSFTVNRGETVALVGESGSGKSVSALSTVSLLGDSAIVEGSVTYDGQEMIGASEQRLMDVRGNDISFIFQEPMTSLNPLHTIRKQMAESLALHQGLVGAAALERILELLVKVGIRDPETRLDAYPHQLSGGQRQRVMIAMALANKPDILIADEPTTALDVTIQAQILELLADLQREENMGMLFITHDLGIVRRIADRVCVMKAGEIVESGSTEEIFANPRHPYTRKLLAAEPKGRPDPVPAGAEEVARTDHLRVWFPIQRGFLRRTVGHVKAVNDASISVRAGETLGIVGESGSGKTTLALAIMRLIGSEGGITFRGEDVRSWSTRELRRLRKDMQIVFQDPFGSLSPRMTCAQIISEGLAIHKVDPHRAPRELVAEVMQEVGLDPATMDRYPHEFSGGQRQRIAIARAMVLRPRLLVLDEPTSALDMTVQVQIVALLRDLQRKYGLAYLFISHDLKVVRAMSHKVIVMRQGDVIEMGETEALFTNAQTDYTRSLIAAAG
Protein: Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6) (P78412)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Homeobox protein Nkx-2.2
- Homeobox protein SIX3
- Oligodendrocyte transcription factor 2
Sequence:
MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQPGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAREGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
Protein: Putative pyridoxal reductase (PL reductase) (PL-red) (EC 1.1.1.65) (Q06494)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative pyridoxal kinase BUD16
- Putative pyridoxal kinase BUD17
- Pyridoxamine 5'-phosphate oxidase
- Uncharacterized protein YGR017W
- Uncharacterized protein YDL144C
Sequence:
MSVADLKNNIHKLDTGYGLMSLTWRAEPIPQSQAFEAMHRVVELSRERGHKAFFNVGEFYGPDFINLSYVHDFFAKYPDLRKDVVISCKGGADNATLTPRGSHDDVVQSVKNSVSAIGGYIDIFEVARIDTSLCTKGEVYPYESFEALAEMISEGVIGGISLSEVNEEQIRAIHKDWGKFLTCVEVELSLFSNDILHNGIAKTCAELGLSIICYSPLGRGLLTGQLKSNADIPEGDFRKSLKRFSDESLKKNLTLVRFLQEEIVDKRPQNNSITLAQLALGWVKHWNKVPEYSGAKFIPIPSGSSISKVNENFDEQKTKLTDQEFNAINKYLTTFHTVGDRYEMA
Protein: Phosphatidylinositol-binding clathrin assembly protein unc-11 (AP180-like adaptor protein) (Uncoordinated protein 11) (Q9XZI6)
Organism: Caenorhabditis elegans
Function: Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin.
Subcellular location: Membrane, clathrin-coated pit {ECO:0000269|PubMed:10397769}. Golgi apparatus {ECO:0000269|PubMed:10397769}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10397769}. Note=Colocalized with clathrin in the Golgi area.
Interaction partners:
- EHS-1
- Probable clathrin heavy chain 1
- Intersectin-1
- Endophilin-A homolog
- AP-2 complex subunit alpha
- SH3 domain-containing protein
- Huntington interacting protein related 1
- Synaptobrevin-1
- Putative stoned B-like protein
- AP-2 complex subunit mu
Sequence:
MQTIEKALHQPMPFTTGGQTISDRLTAAKHSLAGSQLGKTICKATTEEVMAPKKKHLDYLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFCKVKRGREDGLLRTMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRDLIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGEIPDLTRAPASLLEALEAHLIHLEGGKAPPPTQQHVAPHQFTTGFAFSQQPQPALGDAERQRYIELEQERLRQFEDQKKSINSANPFANDVASAAPAPATSAAQPDLLDMFQSSAAPAPQTADVTNPFGNFAAPSAFPTNVPPPAAHSAPFGVQPAPQHSAAPFYANLHQAPPMQSQAPNGHQAAPFGYPNAHPDDLARMTAQMSLNQQGAPAGWNTTTSAVSNNPFGATSAPQPMYTAPMGMYQQPFGAQPMWNPAMAAYGQQYGYGQPVPPQQQHQIQLVHAAMAAKNAAQAQQAQAASADPFGL