wanglab/gogpt-training-data huggingface dataset:
Protein: Scaffold attachment factor B2 (SAF-B2) (Q14151)
Organism: Homo sapiens (Human)
Function: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Vinexin
- Estrogen receptor
- Scaffold attachment factor B1
Sequence:
MAETLPGSGDSGPGTASLGPGVAETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIELEATSKKSAKRCVKGLKMEEEGTEDNGLEDDSRDGQEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGLLDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVEIKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVPHPHPHPPPYPHFTRRY
Protein: Uncharacterized protein C21B10.09 (Q9USW4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Uncharacterized protein C4B3.18
Sequence:
MVFKAHHRSITRQDIELEDLENAPASIASIENDTLEANVGSTPLTAKQKRNIYFLILLYLIQGVPMGLVRGSIPYFLKPNVSYSDLATYSLAAYPYSLKVLWSPIVDTYYCRSFGRRKTWVVPCMLLISSTLLLFSYNVDTWISKGSSYINSFTTWSFLLVFVCATQDIAVDGWSLNMLNPEQLSYASTAQTVGLNTGFFLSFTILLVFTSPEFANTFIRSIPSNEGLITLSGYIKFWAYFTFIASVLVCFWDESNHQEIANISDMWKTIRAALSLKNMRQLLIVHTLGKVGFVANETLTLLKATEFGLSNEMLSLIILINFPLGLALGVYTGRISNYRPLDIWLKGYWGRVVSILLNTILVYMVSNWKHRFPVFFPIFLCYTLNASFSTIQFVALGVFHSKISDPHIGGTYMTILNTLSNLGGSWPQYVMLRMADLLTVSSCSTAPHLTCSADAQKKECQALGGTCLYKRDGYYLTSIVGIFLAISICVSLITPVVRRLTKAPISSWHIHSKIAETYT
Protein: Dynein heavy chain 6, axonemal (Q8BZ42)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
ELFNTTIETSEKSDNLHERLKILLQQTLLTAYTNVSRGLFEQHKLIYSFMLCVDIMREHEQLTEAEWNFFLRGSAGMEKERPPKPEAPWLPIQMWFSCCDLEESFPIFEGLTKHILLRPISIKLGSFETYINPPVWEGYPKQRHEEEKDHVWGLDFSSFHKLILVKCCKEEKVVFALTDFVIENLGKQFIETPPVDLATLYQDMSNSTPLVFILSTGSDPMGAFQRFARESGYAERVQSISLGQGQGPIAEKMIKDAMKTGNWVFLQNCHLAVSWMLAMEELIKTFTDPNQTIKDTFRLFLSSMPCSTFPVTVLQNSVKVTNEPPKGLRANIRRAFTEMTPSFFEENILGMKWRKLIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLNLYCHEGKIPWDALIYITGEITYGGRVTDTWDQRCLRTVLKRFFSPETLDDDYTYSDSGIYFAPLADSLQDFKEYIEDLPLIDDPEIFGMHENANLVFQYKETNTLITTILEVQPRSSSGGQGKSNDEIVQELVASIQTRVPESLQMEGASESLFVKDPQGRLNSLTTVLGQEVDRFNNLLKLIHISLETLNKAIAGLVVMSEEMEKVYQSFLNNQVPSLWSNTAYPSLKPLGSWVKDLILRTEFVDLWLKRGQPKSFWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYNMIPVYRDQAAVIESAKDIQFGTELPMDKELPSPEDGVLVHAMFMDASRWDDKDMVIEDALPGQMNPMLPVVHFEPKQNYEPVHTLYHSPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRISDYWISKGSALLCQLSE
Protein: M1-specific T cell receptor alpha chain (TR alpha chain TRAV27*01J42*01C*01) (P0DSE1)
Organism: Homo sapiens (Human)
Function: The alpha chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a public TR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains. Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:29997621}.
Interaction partners:
Sequence:
MVLKFSVSILWIQLAWVSTQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQPGDTGLYLCAGGGSQGNLIFGKGTKLSVKPIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
Protein: Protein-arginine deiminase type-1 (EC 3.5.3.15) (Peptidylarginine deiminase I) (Protein-arginine deiminase type I) (Q9ULC6)
Organism: Homo sapiens (Human)
Function: Catalyzes the deimination of arginine residues of proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12416996}.
Interaction partners:
Sequence:
MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWNMVP
Protein: Syncytin-Car1 (H2DE99)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Interaction partners:
- FA complementation group M.
Sequence:
MTLFKPFIFLNLLLSYLSLGKANSPNLFLQWAQHYAESLQKSSCWICGLLPLSSSSGLPWWVSPLQGTDWHYLHQYIKDMVIQPNTSIYRDISITNSNVSHWPMVNATWNSPGHRKPFSFLQTAKIMTEFANSKIQSKKALWGISKTSNMRYTEDGYFQVWDEFMWLTPTIGQLNQKALLCWEQRNHTYDAWPNSTRELGWLSSRACNHIIILQATDWFATDWIRRPSIRWLAPNGTQWLCGTNLWPWLPPGWIGRCTLGFPWMQGKLRKEISMPANYPHLLHRWTRSVFHWYDHLVGLFLPQLGIEDIIWHVEALANYTTHALNDTMHALVLLNSEVALMRKAVLQNRMALDIITAAQGGTCAIIKTECCVYIPDNSANVSELLTDMHTQIEAMSDSSGSLNDWISSWYGGNGWSWWKKLLLLIVTVVTLGLLLCCGSFCCCVFCINMSEKLSEQVFSGRRSILRIRPEEHL
Protein: Histone H3-like centromeric protein CENH3 (Centromeric histone CENH3) (Centromeric histone H3) (Q6T367)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (Probable).
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14716315, ECO:0000269|PubMed:16877494}. Note=Localizes in the kinetochore domain of centromeres. {ECO:0000269|PubMed:14716315, ECO:0000269|PubMed:16877494}.
Interaction partners:
- Os02g0782800 protein
- Os02g0784100 protein
- Histone H4
- Histone H4
- Probable lysine-specific demethylase SE14
- Os01g0884500 protein.
- Os06g0255200 protein
- Os03g0207900 protein
- Os09g0544500 protein
- ARID transcription factor
Sequence:
MARTKHPAVRKSKAEPKKKLQFERSPRPSKAQRAGGGTGTSATTRSAAGTSASGTPRQQTKQRKPHRFRPGTVALREIRKFQKTTELLIPFAPFSRLVREITDFYSKDVSRWTLEALLALQEAAEYHLVDIFEVSNLCAIHAKRVTIMQKDMQLARRIGGRRPW
Protein: RuvB-like helicase (EC 3.6.4.12) (Q583J3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RuvB-like helicase
- SNF2 DNA repair protein, putative
- HIT-type domain-containing protein
- Nucleolar RNA binding protein, putative
- Histone H2A
- RNA polymerase II-associated protein 3
- Histone H2A
- Centromere/microtubule binding protein cbf5, putative
- Transmembrane protein, conserved
- YEATS domain-containing protein
Sequence:
MAETNIRAEEVRDLTRVERIGAHSHIRGLGLDDALEARMSSQGMVGQVEARRAAGVVVQMIREGKIAGRCVLLAGGPGTGKTAIAMGMAQALGAETPFTMIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEMIEGEVVEISIDRPSVNPAEAKGRTGQLVLKTSDMESTFDLGLKMIESLQREKVQVGDVITIDKATGRVNKLGRSFIRSKDYDAMSANTRFVQTPEGELSKRKEVVHTVTLHEIDVINSRQQGFLALFAGDTGEIKHEVREQIDQRVAEWREEGKGEIIPGVLFIDEVHMLDIECFSWLNRALESPLAPVVVMASNRGIARIRGTQYKAPHGIPIDLLDRMVIITTKPYSEAELSKIIHIRCEEEDVEMDDEAVALLTMLGKSTSLRYVLQLITTASLVAQKRRSSTVSIHDIKKVYSLFIDLRRSVELLQEHEKDFLFGEADRGAEMSYGAQCQNEEEQ
Protein: Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (Serine/threonine-protein kinase SAK) (J3KR82)
Organism: Homo sapiens (Human)
Subcellular location: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
Interaction partners:
Sequence:
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH
Protein: Putative multidrug resistance protein MdtD (P36554)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Multidrug resistance protein MdtB
- Multidrug resistance protein MdtC
- Multidrug resistance protein MdtA
- Signal transduction histidine-protein kinase BaeS
- Transcriptional regulatory protein BaeR
- Multidrug export protein EmrA
- Probable multidrug resistance protein EmrK
- Cation-efflux pump FieF
Sequence:
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLLLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLTIAGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ
Protein: P-type domain-containing protein (Q21750)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- P-type domain-containing protein
- Glucosidase 2 subunit beta
- Alpha-1,4 glucan phosphorylase
Sequence:
MGKVTLLLLFVLLAFANAAPRFDCLPEPNGNQGACEARGCIWKEDDTGKNAPWCYFKDGVGYNLDSQQGSTYNLRKNGGPSNPWGADSTEIKLTTKSIGSVLNVKIGIDGRYEPPVDFPRETQSSTESLSLSTSFSNGVFSFSVVRQSTNRKLFDTSIGGLIFSDQFIQIATYLPSENMYGWGENTHQSLRHDFTKYLTWAMFARDQPPNSGSLDTVNLYGVHPYYMILEPDGKAHGVLIINSNAQEVTTAPGPSLIYRTIGGNLDMYFFPGPTPEMVTQQYLKFIGKPFLPAYWALGYQLSRYGYKGLAEMKTRIQAVRDAGIPIDIGVADIDYMQRYKDFTTGDDWAGFSDYVKTMHDWGMKLILIFDPAIEATYPSFQRAIAANAKFIEWETKAQVQTAIQNLYPMAKDTKIMLGVVWPDNHVAFPDFLDSTNNTQNWWINEFVNYQSQVAFDGIWIDMNEPSNFGTNQDHPWYFDSDDHPNDAPLFCPTNGSSPWEMPPYKTRAVWRFGDANSGAFLSSNTLCMLAQQDGGKQRFYNVKNLYGLTEAINTQKALFKATGKRGAVVSRSTYPSAGRYAGHWLGDNTARWEDLRTSVIGAQEFNLFGIPYVGSDVCGFIGTTTEELCLRWQQMGAFHSFFRNHNTIGAPAQDPAVWPSVAAATKKANLFRYQYLPYLFSLHFTASLSGATVIRPVFFEYPTDAETFNLGYEFMWGSRILVAPVIYQGTTSVNAYLPTDRWYSLFDYRYGSIMSPGYATVPAPTTSRIPVFVRGYSVIPRQTPSITTTATRSNPFELLIAPCPLGMGEGTLYWDDGETIVNDFNSYDYHQFDFMYNSTATGGSVTITHSKKSSKISLPTLDIIEIFNYPSAPNFRSFTINGKLVNVNVQRSTYSGITKILYISTEGLVNLSSADSIVLQWSNAGNSMFDISSASSDEVGKMKALNTNRYDELYF
Protein: Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1) (Q5M7W1)
Organism: Rattus norvegicus (Rat)
Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BG60}.
Interaction partners:
- Thioredoxin
- NACHT, LRR and PYD domains-containing protein 3
- Thioredoxin, mitochondrial
- DNA damage-inducible transcript 4 protein
- Caspase-1
- E3 ubiquitin-protein ligase
- Thioredoxin domain-containing protein 2
- Tyrosine-protein phosphatase non-receptor type 11
- Interleukin-1 beta
- Vav guanine nucleotide exchange factor 2
Sequence:
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVTVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNVQ
Protein: Pleomorphic adenoma gene like 2 (Q9QZJ1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATHSAQKPHQCMYCDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVLCMASRDVMGAKAFPGMLPMGMYGAHIPTMPSAGMPHSLVHNTLPMGMSYPLESSPISSSAQLPPKYQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLDEALLAKSPANLSEALCAANVDFSHLLGFLPLNLPPCNPPGATGGLVMGYSQAEAQPLLTTLQAQPQDSAGAGGPLNFGPLHSLPPVFTSGLSTTTLPRFHQAFQ
Protein: Cytochrome b6 (P12123)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00633}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00633}.
Interaction partners:
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Cytochrome b6-f complex subunit 4
- Cytochrome c oxidase subunit 3
- Cytochrome b6-f complex subunit 5
- Cytochrome f
- NAD
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 1
- Cytochrome b559 subunit alpha
- Cytochrome b559 subunit beta
Sequence:
MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFSSVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
Protein: Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102) (P13598)
Organism: Homo sapiens (Human)
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P35330}. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P35330}.
Interaction partners:
- Integrin beta-2
- Integrin alpha-L
- CD209 antigen
- Integrin alpha-M
- Intercellular adhesion molecule 1
- Radixin
- Ezrin
- Intercellular adhesion molecule 3
- Moesin
- Junctional adhesion molecule A
Sequence:
MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP
Protein: Pappalysin 2 (Q8BJG6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
EGSSEIAVSTIATFAYQKGPTAETQRKGQSKSRLPRQVQKRQAEDMTGDPQNTPQGFQLWPKEPLKHGDSDSPLEGTIQNGGGASLRRVETFNSQGGLPVLYFTGKRERLLLRPEVLAEIPREAFTVEAWVRPEGGQSNPAIIAGVFDNCSHTVNDKGWALGIRSGKDKGWRDARFFFSLRTDRMKKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVASSRDQFGPLNSPFMASCRSLILGGDSSEDGHYFRGYLGTLVIWSTALSQTHLQHSPLHPSAADELTTLILTATFDPLMEQWAPFRDDLYPRLEVLQDSESQPEILSPLQPPPCGQTACDNVELISQYNKHGPLRREKVIRYQVVNIYDDEGLHPIVSDHQIRRQHEALNQAFSRYNISWQLSVHRVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGFDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNVYFASSVREDLAGSATWPWDKEALSHLGGVVLNPTYYGMLGHTNIMIHEVGHVLGLYHVFKGVSERESCDDPCRETVPSMETGDLCADTAPTPKSKLCRDPEPANDTCGFTLFPGAPFNNYMSYTDDECTDNFTPNQVARMHCYLDLVYQQWSESQKPTPIPIPIPPMVIGQTHKSLTIHWLPPISGVVYDRAPDSMCSACTEDGTFRQYVYKASSGRVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPELHLNHMNMTVPCPAEGCSLELLFQYPVQADTLTLWVTYLSMNSSKAFFDIEILLEHKKSMHLGPLNTFCDIPLTIKLHMDEKVMGAKVYTFDERMEIDAALLTSRPNSSLCSGCKPMSYQVLREPPFSSGLPMVVTHPHRKFTDTEVIPGQMYQYQVQAEAVGELGEASPPLSHIHGGPYCGDGKVERSIGEMCDDGDLLNGDGCSRACELEEGFNCAGEPSLCYRYEGDGVCEDFEKESIITDCGLHTPEGYLDQWASQAYSYHEDKEKCPVSLVTGEPHSMICTSWHPDSSPYHSFPGWFPCVFSLKKDQDAGSEQAKDSLQKDNEIWLEVCFNRPGVAVAIYIFLASDGVTPGEHQQATVTLYLIDVSGSNHSLGTYGLSCQQNPLVINVSHHVNVYPQHTSSMLLNFSSPLVGISAVALRTSSQTSSSAPSNCIPE
Protein: Phosphatidylinositol 4-phosphate 5-kinase 1 (AtPIP5K1) (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase 1) (Diphosphoinositide kinase 1) (PtdIns(4)P-5-kinase 1) (Q56YP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4-bisphosphate.
Interaction partners:
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-kinase beta 2
- Phosphatidylinositol 4-kinase alpha 1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
- Phosphoinositide phospholipase C 1
- Phosphatidylinositol 4-kinase alpha 2
- Peptidyl-prolyl cis-trans isomerase Pin1
- Type IV inositol polyphosphate 5-phosphatase 7
- Phosphoinositide phospholipase C 3
- Phosphoinositide phospholipase C 2
Sequence:
MSDSEEDEEEEEASEVILSSVVQKKKKKNLRFGEEVERRDGLVLLAQSTPMVRSRSQGTTRRVTPTPLVDVEKPLPNGDLYIGSFSGGFPHGSGKYLWKDGCMYEGDWKRGKASGKGKFSWPSGATYEGEFKSGRMEGFGTFTGADGDTYRGTWVADRKHGHGQKRYANGDFYEGTWRRNLQDGRGRYVWRNGNQYTGEWRSGVISGKGLLVWPNGNRYEGLWENGIPKGNGVFTWSDGSSCVGAWNESNIMRSFFNGVEKNDLIVGNRKRSSVDSGAGSLGGEKVFPRICIWESDGEAGDITCDIIDNVEASMIYRDRISVDRDGFRQFKKNPCWFNGEAKKPGQTISKGHKKYDLMLNLQLGIRYSVGKHASIVRDLKQTDFDPKEKFWTRFPPEGTKTTPPHQSVDFRWKDYCPLVFRRLRELFQVDPAKYMLAICGNDALRELSSPGKSGSFFYLTQDDRFMIKTVKKSEVKVLLRMLPSYYKHVCQYENSLVTRFYGVHCVKPVGGQKTRFIVMGNLFCSEYRIQRRFDLKGSSHGRSTAKPEGEIDETTTLKDLDLNFSFRLQRNWYQELMKQIKRDCEFLEAERIMDYSLLVGVHFRDDNTGEKMGLSPFVLRSGRIDSYQNEKFMRGCRFLEAELQDMDRILAGRKPSIRLGANMPAKAERMARRSDFDQYSSGGASYPSHGEMYEVVLYFGVIDILQDYDITKKIEHAYKSLQADPASISAVDPKLYSKRFRDFISRIFIEEG
Protein: Uncharacterized protein (Q38FW7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAKRTVTALCTIPEEDPVPLFVGREDGTVDYYKLSDITRGGTPIVTFYGHTKTVTAIVAPALDQVFTCAMDGNIRQWSVDPEQETPQRCLKLIKIVVPLRCLAMCGDRLYAGDDNGCLQVISGERRSALPGHKDVLSCIACASEEAQIIVTGGYDNQIRVWDGRTGKTVRVLIGHTNHVKCLRVVAEGQLLFSFSRDLTMKIWRLPDPSEMDQNEALYISGILNRQATVSFKEPGADEDENDLESQGELAEGALSHSENVAPQTDGLVRSGSLSVSNSQAAEGNKSSLKSALKGRPEPPIQRVDAVGTVEIPITPHTVAARREEAAFCFVGASEGYVLGIDVRALSKTVLQFLSRNSSCVRMDTREMRQTLLIAKRVIFRRCRKAVAQKKKELVKAARKARAAKRAEERKERAAARAAARAERKARAAEEDEEDEEEDEMEEGDDEFAEEEEELEDEEEQSEEDDPLELLDEQQKKELSEFTQEREKERNAELADLREAVEKRSEAMKSVSTATYDTPRDKFFRLSFTSYKVIGDEPVLAMAIAPGPAAFAVQMDRVIPVDITPGITYL
Protein: F-box only protein 16 (Q8IX29)
Organism: Homo sapiens (Human)
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MMAFAPPKNTDGPKMQTKMSTWTPLNHQLLNDRVFEERRALLGKWFDKWTDSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRFNWYINFSPTPFEQGIWKKHYIQMVKELHITKPKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHPTDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSRRNPFPLCP
Protein: Coagulation factor XIII B chain (Fibrin-stabilizing factor B subunit) (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain) (P05160)
Organism: Homo sapiens (Human)
Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
Subcellular location: Secreted {ECO:0000269|PubMed:26247044, ECO:0000269|PubMed:4405643}.
Interaction partners:
- Coagulation factor XIII A chain
- Fibrinogen alpha chain
- Prothrombin
- Fibrinogen gamma chain
- Fibrinogen beta chain
- Vitamin K-dependent protein C
- Homogentisate 1,2-dioxygenase
- Histidine-rich glycoprotein
- Heparin cofactor 2
- Antithrombin-III
Sequence:
MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRT
Protein: Protein SAP1 (SIN1-associated protein) (P39955)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Vacuolar protein sorting-associated protein IST1
Sequence:
MDSQRSHHILTRLTKIRRRPQQPLTDFTELYSRIANETIYYLNLEEKKRYKEALQGWKALTTDVLFKQTLIEHNYPNTQSYTKDEVSLQNGIRELYHKSVMHLKRVKKLVREEPAPRNDMPSSKTYTNHSSSFTRSTEPPPVFQMVPGRMMKTLRNRNACGYKTAYSNPSLSSYGNSTSIKRGEDAENIRVNFVPSKPLSNNASRQHKNPIEHNDPPLKKETELYSDKYISEPILIDLTNDEDDHDVGILKGHNVFDEEESDGFEFDVSDYYDNFSEVDVEEEEEEKEERRRIKTLEAIQQQMSDLSVTSSTSSNKSVSSSENVPGSCIQSLPTTAPALPSLPPPPLLNVDRASSTGALKPHSLETSTTMDSSKIRNPQISKLMKNNHVPYLKGTKSTPTLITKSTPTFITRSKSNTKPIIKSNASSPTSSLTVPNSVIQKPKTAAMAAKRVLNSKKVASNPALNTTKKSHPILKSKTAKVPNSSSKKTSSHPSRPVSNSKPYSHGASQNKKPSKNQTTSMSKTNRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQREEPEIDKKVLREILEDEIIDSLQGVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYPFLRPDLFRGLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEKLVRALFAIAKKLSPSIIFVDEIDSIMGSRNNENENESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDTNGDEDDTRVLVLAATNLPWSIDEAARRRFVRRQYIPLPEDQTRHVQFKKLLSHQKHTLTESDFDELVKITEGYSGSDITSLAKDAAMGPLRDLGDKLLETEREMIRPIGLVDFKNSLVYIKPSVSQDGLVKYEKWASQFGSSGS