wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger SWIM domain-containing protein 5 (Q9P217)
Organism: Homo sapiens (Human)
Interaction partners:
- Kelch domain-containing protein 10
Sequence:
MADGGEREELLSPSPVSPAKRQCSWPSPQAHHPRGSPGAAGGGAGGVGSSCLVLGARPHLQPDSLLDCAAKTVAEKWAYERVEERFERIPEPVQRRIVYWSFPRNEREICMYSSFQYRGGPGAGAAGGAAGASPAEEGPQPPPGAAAPAGSAPGGVAAGASPGLGAGAGAAGCGGEGLPFRRGIRLLDSGSVENVLQVGFHLSGTVTELATASEPAVTYKVAISFDRCKITSVTCGCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFLSQGGYCGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFVADPRLTLWRQQGTNMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDVCPLEDGNYGHELPNITNALPQSAIHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQRIISSDVYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMNESRPPVYQHVPVAAGSPNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKVCRNEEQLLSQLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYKLALRAMRLPVLENSASAGDTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIATPTDSSTDSTLLNVALELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWACALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHYGEFIEFLSKARETFLLPQDGHLQFAQFIDNLKQIYKGKKKLMLLVRERFG
Protein: Zinc finger protein 97 (E9PZP6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Zinc finger protein 960
Sequence:
MMRILSLPTENAVTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGYNWEEDNIEEDCENSGRPTRHLQRDGPSNTGEKPFECIQYDGAFARNHHQLHKDTGSFMSYTDRQIHRRPHTEEKVYDGNQCGKTFSCHNHFEIRKGTYTGEKPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKDFTHHSTLHIHKRIHTREKTYKCNQCMTIAHLQCHKITHTGEKLCEYNQCWKAFAYHKTLQIHERTHTGEKLYQCNQCAKAFPYHRTLQIHERTHTGEKPYECNQCGKAFACLRNLQNHKTTHTGEKPYECNQCGRAFRQYVYLQCHERIHTREKPFECNQCGKAFAHHSTLQRHKRTHTGEKPYECNQCGKAFACPRYLQIHKRTHTGEKPYECNQCGKAFACYQSFQIHKRTHTGEKPYECNQCGKAFACNRYLQIHKRTHTGERPYECNQCGKAFTCRSNLQIHKRTHTGEKPYECNQCGKAFTQFFPLKRHEITHTKEKPYECNQCGKAFTRHSTLQIHKRTHTGEKPV
Protein: Variant surface glycoprotein (VSG), putative (Q38G41)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MTAPVLGATMLTIALHLVTSGSLATIPEGANKHEHAVLCEVLAIVDADLDIPPQESVDEASYNKIRNLNFSTSTTDWRKTFYSDDALTKPHPEAQPAHKKIADYAKYWPDWHGAATALAATKKPDEVEKAKLDELTHQSRQIAHARVRAIAETARAAKEKALQTAGEAEVIDKAEELKALKTVFFGADSAAAATVTTTNAFGTGTINARQTACEADPADGKAKTLVAQLMCVCTKATQGSALSKACTAAADGSQGWNSGSGSPADTDASAVAKTCANTGESKITATRLRQAITNVAKLVHLTSDGTGYIGVYQATGCTGADNAGMCVKIPNYKSNPTDGIKKLQWTSTLENLANKLEARTRYNTIISKLNEQLRSSSEQAEETIQLTKREEAARSTATKEQTQKSTTATQAQNTLINECEKITKAAQCKEKKPACEWQNKAAEDGPHCKLNATNVEQQATQAGTGDGAAATTTDKCGAAKTPEECAAVKGEIPKDKKAVCGWIEGKCQDSSIIINKKFALSVVSAAFMALLF
Protein: Uncharacterized protein C17A5.09c (O13771)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Type 1 phosphatases regulator ypi1
- Protein phosphatase 1 regulatory subunit SDS22
- Serine/threonine-protein phosphatase PP1-2
Sequence:
MKVKSILKHSRMSSPSLETDSMESGQQQNMVSSTPSIDMNESDCSGTGTPSEERIRRLRWDEENLSKAEQQKSAKMKITEPKTPFQRFLLPDDEVPEINLDETDSKDDFTAGTLGDTLGTLPSTRVSKDSKDDNVSFSSDKKQFYVKKEPFPVPCTEPTTSGDRYTVRMKAPTPKYSTDNHLPSKKELFPRETKPQVEVVHARINNPDDHLRTHPSVNNLGKDSDHADKMYNEGVILGEDEAMEEEALSEAEENIPKKKPDFNELRKKHYFAMAKPLKRDELESSGTESDLERDNSDSGSASDVNMNENE
Protein: Mitosis inhibitor nif1 (Nim1-interacting factor 1) (P87159)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a negative regulator of mitosis. It interacts with the C-terminal of nim1, thereby inhibiting its kinase activity which phosphorylates wee1.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- tRNA modification GTPase mss1
- Mitosis inducer protein kinase cdr1
- DYRK-family kinase pom1
- Obg-like ATPase 1
- Protein arginine N-methyltransferase skb1
Sequence:
METMQSRTYAGLTKLNTTTALLNKKDGNDDDKAEHSKRSGYHGLSPLDALALKHRDLNRKLNLRAMMSKSEDNLQILKETTSGSSSDLLNIESPASPAEASSPFTVRTPTVHDPEHYFVAQKLSSVFGTPDLEDETDFFDYFSAAPDVHPNDIFDSYNSNNIAESFDDDNYYNSLLPPNAPYYHEIEPPRTASNTSPTPNSIKSAHPAEPPKRPAFTRSATSPDKILPTRIKSKDTVSSGDSTPLSGSSSSKGMLMSMSTSENHSLSSNPELSNSNLLAKNESPADVSNNESGNESSKEPDKEHSTPIHPTTPVSRCARPSSRQQTISILQAQSPFLKKSDKERANLNKTMVSINKSINIHQSIHEISCPHHSSSDNCLFILISLMDRLHSPVLKQLDVSLQSLTMTAIRYIDLNYVDVQYTNLRGGAYGNGNNSESSDNAQLKKEEHLNLAIHFHLLNDHDKCFWHTGMASSYEDYTATFIYGLYLRHGLACSPKTHVSFLFLLKTATQLLNKLVECLHSSDLGLNDTTPNEKLSTEYNQQRLLLALILYELGVCFMHGWGITRDRYLALHLIKLSGAWGDADAQFEAGLQMSLGAVSDKDSHMAAYYYRLAGFQGISPPSKCKWVYKSKYSLAANHKVPAASEVAYVSAIVENLESHSLKFSTKPKAKLRSLITSVRYL
Protein: Protein GAPT (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane) (Q8CB93)
Organism: Mus musculus (Mouse)
Function: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MLECFESSPVAVAVGVSLLVLLLLCGIGCAWHWNRRESTPFTLPKFMQRRSSRQKDVTKTVSSSAYVISPSMKASVESKGHKSTAKRNKMHGNYENVEVCPPCTEGTTEKALYENTQPSNLEEHVYGNQTDPLYYNFQKPSPPPPQDDDIYILPDCD
Protein: VWFA domain-containing protein (O53703)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Possible membrane oxidoreductase
- Possible oxidoreductase
- ParD-like antitoxin of type II toxin-antitoxin system
- Carbon monoxide dehydrogenase
- Probable carbon monoxyde dehydrogenase
- Probable carbon monoxyde dehydrogenase
- UDP-N-acetylglucosamine kinase
- Probable carbon monoxyde dehydrogenase
- MobA-like NTP transferase domain-containing protein
Sequence:
MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQLVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR
Protein: Uronyl 2-sulfotransferase (EC 2.8.2.-) (Q8BUB6)
Organism: Mus musculus (Mouse)
Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MKKKQQQHPGGGTDPWPHGAPVGGAPPCLGSCKRRIPLLPFLRFSLRDYGFCMATLLVFCLGSLFYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVSRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVRKTVPSPEAVQILYQRMRYEYEFYHYVREQFHLLKRKLGLKSRVSGPPVRPQFFIPTPLETEEPIDDEEQDDEKWLEDIYKR
Protein: Putative alanine aminotransferase (EC 2.6.1.2) (Glutamate pyruvate transaminase) (GPT) (Glutamic--alanine transaminase) (Glutamic--pyruvic transaminase) (Q10334)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:P52893}.
Interaction partners:
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Arginine biosynthesis bifunctional protein ArgJ
- Probable NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
- Aspartokinase
- Fumarate hydratase, mitochondrial
- Amino-acid acetyltransferase, mitochondrial
- Probable isocitrate dehydrogenase, mitochondrial
- Probable succinate dehydrogenase flavoprotein subunit, mitochondrial
Sequence:
MSDLDGFCQNAFSDLNSLNQQVFKANYAVRGALAILADEIQDDLLENPSSYPFSEIVYANIGNPQQMGQSPITFVRQVLSLCQYPTLLDHAEEKWFQNLFPTDVVQRSKMLLKESGSLGAYSASQGIPLVRRHVADFIRARDGFDCEPSDIYLTSGASHAARLIMTLIIARPTDGVMVPAPQYPLYGAQIDLMSGSMVSYSLSEENNWDIDFDQFKKSFDEASKKGINVRLCVVINPGNPTGACISENSMEKVLRFAKAKGIVLLADEVYQNNIYQNKFHSFRRKLGELREKEPDNHWDQVSLISVNSVSKGQFGECGQRGGYLDVVNIPEPAKDQILKLATIDICPPVAGQLLVDMLVNPPKPGDPSYDLFIKEVDEIHEALRLQCRQLYEGTKRMKRVSCLEPHGAMYLHPSVSLPEKLITTAKAQKIQPDEFYAIELLKRSGICVVPGSGFGQPEGDYHIRITFLAKGTEYIERFVKAHNEIMDLYE
Protein: Conjugal transfer protein (Q48B09)
Organism: Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Interaction partners:
Sequence:
MTFRLALSGLLSAALLAGCGSAPKLSKPEGQWEDMPFTHAPAPRAAPVTKPAPVHDRVLPAASPAPKAQSLKTTQQKRPAAASPAKPAEAPPNDSKCSAN
Protein: GPI-anchored protein 53 (Q5AMJ5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:19824013}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19824013}.
Interaction partners:
Sequence:
MKFQLLTLVSIATTTLAINLEQVRLINDDELMVQDAQFDYPAIVNLKDQDAEIAKKTITSSSSTTTTTTAKKDKKTTSTTSASSTTTTSTKSNSTSPSSSSSKKHKSETASITKTGGADSVAAAAAVGGPILAALALLL
Protein: Kinesin-like protein (B3GWB6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLVETAREQFGAQRRPPISGSGSFVEATIPEETIRFCGENVVVFSALERFVPEVTDSDPSTFSNSMMMSARRPSIENLTIDASKVLVPILNQSTMILKNSKNGQARNDTMPPNGSMRRSQN
Protein: Fluoride export protein 2 (P0CU20)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q08913}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein PB16A4.07
- Uncharacterized protein C25B8.20
- Probable circularly permuted 1,3-beta-glucanase P23A10.11c YJL171C
- Putative amidase PB8B6.03
- Uncharacterized protein PB1A10.16
- Putative uncharacterized protein C27E2.12
- Uncharacterized protein C16G5.19
- Putative lysine N-acyltransferase C17G9.06c
- Putative uncharacterized protein C23C4.04c
- Uncharacterized protein C685.08
Sequence:
MLLTQSYFCIMSMLGTLARLGLTALNTYPGAPFSGLLWVQFVGCVIMGFCQTESVFFPRPKHNATFLLAITTGFCGSLTTFSSWMLQMFTGMANLDPFERRGRGYSFLSVVSDFMVTMCIAMSSLIWGKQIGKTTGQWRIGKVAFAWPIPAHTHIVVRVLLLLLSICFFVGAAFYTAYTTNVTHRGIGFSLIFSPFAALTRLYLARFLNSPQYFIPYGTLCANVFATLLLSIMYMIPQITHCTPVSRSVMYGIQNGFCAVLSTLSTFSNELHTMPIKRAYIYCIISVAISFSICVIVDGATAWGHGYTEKY
Protein: G-protein coupled receptor 12 (P47775)
Organism: Homo sapiens (Human)
Function: Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV
Protein: Peroxisomal (S)-2-hydroxyacid oxidase GLO4 (EC 1.1.3.15) (Glycolate oxidase 4) (AtGLO4) (GOX 4) (lHAOX1) (Q9LJH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Oxidase that catalyzes the oxidation of a broad range of 2-hydroxyacids to the corresponding 2-oxoacids, with a reduction of O2 to H2O2. Displays the highest activity with the long-chain fatty acid 2-hydroxydodecanoate and has intermediate activity with 2-hydroxyhexanoate, 2-hydroxyoctanote, and the short-chain hydroxyacid (S)-lactate (L-lactate). With much lower activity, it can also use glycolate, leucic acid, valic acid, and isoleucic acid as substrates in vitro. Cannot use 2-hydroxyhexadecanoate or D-lactate as substrates. May be involved in a general medium- and long-chain fatty acid catabolic pathway such as alpha-oxidation.
Subcellular location: Peroxisome {ECO:0000250}.
Interaction partners:
- Serine--glyoxylate aminotransferase
- Glyoxylate/hydroxypyruvate reductase A HPR2
- Glycerate dehydrogenase HPR, peroxisomal
- Glutamate--glyoxylate aminotransferase 2
- Phosphoglycolate phosphatase 1A, chloroplastic
- Phosphoglycolate phosphatase 2
- Malate synthase
- Glutamate--glyoxylate aminotransferase 1
- Isocitrate lyase
- Catalase-2
Sequence:
MDQIVNVDEFQELAKQALPKMYYDFYNGGAEDQHTLNENVQAFRRIMFRPRVLVDVSNIDMSTSMLGYPISAPIMIAPTAMHKLAHPKGEIATAKAAAACNTIMIVSFMSTCTIEEVASSCNAVRFLQIYVYKRRDVTAQIVKRAEKAGFKAIVLTVDVPRLGRREADIKNKMISPQLKNFEGLVSTEVRPNEGSGVEAFASSAFDASLSWKDIEWLRSITKLPILVKGLLTREDALKAVEAGVDGIVVSNHGARQLDYSPATITVLEEVVHAVKGRIPVLLDGGVRRGTDVFKALALGAQAVLIGRPIVYGLAAKGEDGVKKVIDMLKNEFEITMALSGCPTIDDVTRNHVRTENERIKSML
Protein: RT1 class I, A1 (Q6MGB9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGAMAPRTLLLILAAALAPTQTRAGSHSMRYFDIAVSRPGLGEPRFIIVGYVDDTEFVRFDSDAEKPRYEPRAPWMEPEGPEYWEEQTRRAKEGEQTFRVNLRTALHYYNQSEDRSHTIQRLSGCDVGSDGRLLRGYEQYAYDGRDYIALNEDLKTWTAADFAARISRNKWDQAGVAERLRAYLEGECVEWLRRYLELGKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVEHEGLPEPLSQRWEPPPSTDSNMETTVIYVVLGAVAIIAAVIIGAVVTVVRKRRRNTGGKGVYTPAPGTDSSQSSDVSLPDCKA
Protein: Kinesin-like protein (E9ABZ2)
Organism: Leishmania major
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MMSAEPPSSQPYISDVLRRYQLERFQCAFASSMTIKDLLALQPEDFNRYGVVEAMDILRLRDAIEYIKANPLPASRSGSDVLDNDGDGDGEGDDSTPEGKEGCSTERRRQYTARGTTVLCRSTDTAEEVKRKSRILVAIRKRPLSAGEQTNGFTDIMDADNSGEIVLKEPKVKVDLRKYTHVHRFFFDEVFDEACDNVDVYNRAARALIDTVFDGGCATCFAYGQTGSGKTHTMLGKGPEPGLYALAAKDMFDRLTSDTRIVVSFYEIYSGKLFDLLNGRRPLRALEDDKGRVNIRGLTEHCSTSVEDLMTIIDQGSGVRSCGSTGANDTSSRSHAILEIKLKAKRTSKQSGKFTFIDLAGSERGADTVDCARQTRLEGAEINKSLLALKECIRFLDQNRKHVPFRGSKLTEVLRDSFIGNCRTVMIGAVSPSNNNAEHTLNTLRYADRVKELKRNATERRTVCMPDDQEEAFFDTTESRPPSRRTTTRLSTAAPLFSGSSTAAPALRSTLLSSRSVNTLSPSSQAKSTLVTPKPPSRDRTPDMVCTKRPRDSDRSGEDEVVARPSGRPSFKRFESGAELVAAQRSRVIDQYNAYLETDMNCIKEEYQVKYDAEQMNANTRSFVERARLLVSEKRRAMESFLTQLEELDKIAQQVADITAFQQHLPPT
Protein: Iron-sensing transcriptional repressor (Transcription factor gaf2) (Gaf-2) (Q10134)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcriptional repressor that binds the consensus promoter sequence 5'-[AT]GATAA-3' during iron-replete conditions to down-regulate transcription of target genes. Represses the expression of the iron transporter fio1 in response to high iron concentrations. Also represses the expression of str1, str2 and str3. Represses the expression of shu1 in presence of iron.
Subcellular location: Nucleus {ECO:0000305|PubMed:11956219}.
Interaction partners:
- Monothiol glutaredoxin-4
- CCAAT-binding factor complex subunit php4
- Transcriptional repressor tup11
- Transcriptional activator hap3
- Uncharacterized bolA-like protein C8C9.11
- Iron transport multicopper oxidase fio1
- Transcriptional repressor tup12
- Transcriptional activator hap2
- Plasma membrane iron permease
- Transcriptional activator hap5
Sequence:
MAAKPAPFGQSCSNCHKTTTSLWRRGPDNSLLCNACGLYQKHRKHARPVKSEDLKDISPLIQQVCKNGTCAGDGFCNGTGGSASCTGCPALNNRIRSLNASKSQSGRKSLSPNPSSVPSSTETKASPTPLESKPQIVSDTTTETSNGTSRRRSSHNQHEDSSPPHEPSVTFCQNCATTNTPLWRRDESGNPICNACGLYYKIHGVHRPVTMKKAIIKRRKRLVFNGNANESQHNLKRMSSGDSGSSVKQQSTRDGPFSKSFPNGNGHASGNSGEGLAEHGMNTGVLPPASTFPSYNSNFTGFLPSSFNPSPLMTLSRLAAGEPDNNGKVYYSYGPTQEQSILPLPENKHEGLPPYQNEYVPNGIRANQVVYPGQLVAVGNDSSKQLSESTTSNTDNNGVATANQSNPLGMKFHLPPILPVGESVCLPPRTSAKPRIAEGIASLLNPEEPPSNSDKQPSMSNGPKSEVSPSQSQQAPLIQSSTSPVSLQFPPEVQGSNVDKRNYALNVLSQLRSQHDLMIQELHNLNQHIQQIDEWLRSSDNENMASEHIKSSTPAVVASGALQT
Protein: Delayed minus-nitrogen induction protein 2 (Q9USS9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein mlo2
Sequence:
MERGTSKFSWIGLVARIYNYIPHPSIFSNAILGIAWLFLIFLCCSCLTKSSIFARLLRVKNETTTVDVGFFGVCDQAINSTSRVCHELRNWDQTTGGLAYETSRFAWLQVHPVLLAIVVVFSTLSIVLTILKYLAPAYIRQWSISCLTTSTAACLLLALQMALAHISANSYAVGMNLTGKATAKFGVAAAVFGWISSGFFLLFSLIHLGLWTIERNKQKLFEETSLSFSFITTKLRLIETQYFICKDY
Protein: Phosphatidylinositol 4-phosphate 5-kinase 9 (AtPIP5K9) (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase 9) (Diphosphoinositide kinase 9) (PtdIns(4)P-5-kinase 9) (Q8L850)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in sugar-mediated root development. Interaction with CINV1 induces repression of CINV1 activity and negative regulation of sugar-mediated root cell elongation.
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Nucleus.
Interaction partners:
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-kinase beta 2
- Alkaline/neutral invertase CINV1
- Phosphatidylinositol 4-kinase alpha 1
- Phosphoinositide phospholipase C 4
- Phosphoinositide phospholipase C 6
- Phosphoinositide phospholipase C 1
- Phosphatidylinositol 4-kinase alpha 2
- Phosphoinositide phospholipase C 2
- Phosphoinositide phospholipase C 3
Sequence:
MSGLDVRGAVSFAERTKSVDALTKKEILSALNSGEVSETSEDARFRVRELVLPDGESYSGSLLGNVPEGPGKYIWSDGCVYDGEWRRGMRHGIGNMRWASGASYDGEFSGGYMHGSGTYVDANKLTYKGRWRLNLKHGLGYQVYPNGDVFEGSWIQGLGEGPGKYTWANKNVYLGDMKGGKMSGKGTLTWVTGDSYEGSWLNGMMHGVGVYTWSDGGCYVGTWTRGLKDGKGSFYSAGTRVPVVQEFYLNALRKRGVLPDMRRQNQVASSVNMENLRVGVNRNKLSKGSLINLEQSRNGRVSLERRWSLEVSIEKVIGHGYSDLSTAVLDSGSSVQYKANIPILEREYMQGVLISELVVNNGFSRTSRRAKRKHKRLVKEAKKPGEVVIKGHRSYDLMLSLQLGIRYTVGKITPIQRRQVRTADFGPRASFWMTFPRAGSTMTPPHHSEDFKWKDYCPMVFRNLREMFKIDAADYMMSICGNDTLRELSSPGKSGSVFFLSQDDRFMIKTLRKSEVKVLLRMLPDYHHHVKTYENTLITKFFGLHRIKPSSGQKFRFVVMGNMFFTDLRIHRRFDLKGSSLGRSADKVEIDENTILKDLDLNYSFFLETSWREGLLRQLEIDSKFLEAQNIMDYSLLLGVHHRAPQHLRSQLVRSQSITTDALESVAEDDTIEDDMLSYHEGLVLVPRGSENTVTGPHIRGSRLRASAVGDEEVDLLLPGTARLQIQQGVNMPARAELIPGREDKEKQILHDCCDVVLYLGIIDILQEYNMTKKIEHAYKSLHFDSLSISAVDPTFYSQRFLEFIKKVFPQNNKS
Protein: Scavenger receptor class B member 1 (SRB1) (SR-BI) (P97943)
Organism: Rattus norvegicus (Rat)
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8WTV0}; Multi-pass membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250|UniProtKB:Q61009}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. {ECO:0000250}.
Interaction partners:
- Apolipoprotein B-100
- CD81 antigen
- Apolipoprotein A-I
- Toll-like receptor 4
- Albumin
- Toll-like receptor 2
- P-type phospholipid transporter
- Toll-like receptor
- Thrombospondin-1
- Apolipoprotein E
Sequence:
MGVSSRARWVALGLGVLGLLCAALGVIMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPSEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSYIENRSLRFQPDRSQGSESDYIVLPNILVLGGAVMMEDKPTSLKLLMTLGLVTMGQRAFMNRTVGEILWGYEDPFVNFLSKYFPDMFPIKGKFGLFVGMNDSSSGVFTVFTGVQNFSKIHLVDKWNGLSEVNYWHSEQCNMINGTAGQMWAPFMTPESSLEFFSPEACRSMKLTYQESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSQPHFYNADPVLSEAVLGLNPDPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGVGQTGKIEPVVLPLLWFEQSGMMGGKTLNTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIIYQLRSQEKCFLFWSGSKKGSQDKEAMQAYSESLMSPAAKGTVLQEAKL
Protein: Large ribosomal subunit protein uL22c (50S ribosomal protein L22, chloroplastic) (P0C445)
Organism: Oryza sativa subsp. indica (Rice)
Function: This protein binds specifically to 23S rRNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein uL16c
- Large ribosomal subunit protein uL3m
- 60S ribosomal protein L21
- 60S ribosomal protein l44
- KOW domain-containing protein
- Uncharacterized protein
- Large ribosomal subunit protein bL33c
- 60S acidic ribosomal protein P1
- 60S ribosomal protein L29
- Large ribosomal subunit protein uL5c
Sequence:
MTSFKLVKYTPRIKKKKSGLRKLARKVPTDRLLKFERVFKAQKRIHMSVFKVQRVLDEIRWRYYEETVMILNLMPYRASYPILKLVYSAAANATHYRDFDKANLFITKAEVSRSTIMNKFRPRARGRSSPIKKTMCHITIVLNIVKKSK
Protein: Nitric oxide reductase (EC 1.7.99.-) (Q9JYE2)
Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Interaction partners:
- Copper-containing nitrite reductase
- Cytochrome
- Cytochrome c oxidase subunit III
- NosR-related protein
- Hemerythrin-like domain-containing protein
- Sulfatase-modifying factor enzyme-like domain-containing protein
Sequence:
MGQYKKLWYLLFAVLAVCFTILGYMGSEVYKKAPPYPEQVVSASGKVLMTKDDILAGQSAWQTTGGMEVGSILGHGAYQAPDWTADWLHRELVAWLDLTAQQTYGKKFDEVSPEEQAVLKTRLADEYRNQSRVKEDGSVVISDTRVKAIESILPYYHGVYSDDPKFQTTREHFAMKNNTLPSQEAREKLFNFFFWTSWSASTNRPDENFTYTNNWPHEPLINNVPTTENYMWSFTSVVLLLMGIGLLMWGYSFLTKHEEVEVPSEDPISKIQLTPSQKALGKYVFLTVALFVVQVLLGGLTAHYTVEGQGFYGIDEALGFEMSDWFPYALTRTWHIQSAIFWIATGFLTAGLFLAPIVNGGKDPKFQRAGVNFLYIALFIVVGGSYAGNFFALTHILPPEFNFWFGHQGYEYLDLGRFWQLLLMVGLLLWLFLMLRCTVSAFKEKGVDKNLLAIFVASMVGVGVFYAPGLFYGEKSPIAVMEYWRWWVVHLWVEGFFEVFATAAFAFVFYNMGFVRRSTATASTLAAAAIFMLGGVPGTLHHLYFSGSTSASMAIGACFSALEVVPLVLLGREAYEHWSYQHLSDWAKRLRWPLMCFVAVAFWNMIGAGVFGFLINPPISLFYIQGLNTSAVHAHAALFGVYGFLALGFVLLVARYLKPNAQFDDKLMTWGFWLLNGGLAGMIAISLLPVGAIQAYASITHGLWYARSEEFLQMEILDTLRWVRTAADLVFIGGAICVAIQATKIVFGRDK
Protein: Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2) (DAN domain family member 3) (Protein related to DAN and cerberus) (Q9H772)
Organism: Homo sapiens (Human)
Function: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Bone morphogenetic protein 2
- Bone morphogenetic protein 4
- Bone morphogenetic protein 7
- Gremlin-1
- Bone morphogenetic protein 6
- Growth/differentiation factor 5
- Bone morphogenetic protein 5
- Growth/differentiation factor 9
- Sclerostin
- Chordin
Sequence:
MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ