wanglab/gogpt-training-data huggingface dataset:
Protein: Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) (Q9NR80)
Organism: Homo sapiens (Human)
Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Subcellular location: [Isoform 3]: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}.
Interaction partners:
- Adenomatous polyposis coli protein
- Cell division control protein 42 homolog
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 3
- Spermatogenesis-associated protein 13
- Adenomatous polyposis coli protein 2
- Transforming protein RhoA
- Ras GTPase-activating-like protein IQGAP1
- Ras-related C3 botulinum toxin substrate 1
- Kinesin-associated protein 3
Sequence:
MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPHRSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSISRLAPFRK
Protein: Small ribosomal subunit protein uS7cz/uS7cy (30S ribosomal protein S7, chloroplastic) (Q6ENC1)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- 40S ribosomal protein S16
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS12c
- Large ribosomal subunit protein uL4 C-terminal domain-containing protein
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein eS31 domain-containing protein
- 40S ribosomal protein S17
Sequence:
MSRRGTAEKRTAKSDPIFRNRLVNMVVNRIMKDGKKSLAYQILYRAVKKIQQKTETNPLLVLRQAIRRVTPNIGVKTRRNKKGSTRKVPIEIGSKQGRALAIRWLLEASQKRPGRNMAFKLSSELVDAAKGGGGAIRKKEATHRMAEANRALAHFR
Protein: Molybdopterin synthase sulfur carrier subunit (MPT synthase subunit 1) (Molybdenum cofactor biosynthesis protein D) (Molybdopterin-converting factor small subunit) (Molybdopterin-converting factor subunit 1) (Sulfur carrier protein MoaD) (P30748)
Organism: Escherichia coli (strain K12)
Function: Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin.
Interaction partners:
- Cyclic pyranopterin monophosphate synthase
- Molybdopterin-synthase adenylyltransferase
- Molybdopterin synthase catalytic subunit
- Molybdenum cofactor biosynthesis protein B
- GTP 3',8-cyclase
- Molybdopterin molybdenumtransferase
- Sulfur carrier protein TusA
- Sulfur carrier protein ThiS adenylyltransferase
- tRNA sulfurtransferase
- Thiazole synthase
Sequence:
MIKVLFFAQVRELVGTDATEVAADFPTVEALRQHMAAQSDRWALALEDGKLLAAVNQTLVSFDHPLTDGDEVAFFPPVTGG
Protein: Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) (P09104)
Organism: Homo sapiens (Human)
Function: Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}.
Interaction partners:
- Pyruvate kinase PKM
- Phosphoglycerate mutase 1
- Probable phosphoglycerate mutase 4
- Pyruvate kinase PKLR
- Glucose-6-phosphate isomerase
- Phosphoglycerate mutase 2
- Bisphosphoglycerate mutase
- Phosphoglycerate kinase 1
- Triosephosphate isomerase
- Phosphoenolpyruvate carboxykinase, mitochondrial
Sequence:
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
Protein: DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) (Q8MS06)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSVDIASTIKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQHRNGNMYRGYGDVVYSVLKPRCFNPPSNLRLKEIHQMLDTIANEDTEVKQQQLIRFTEQASPEEQKWLIRLLLKSLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPMLCERFPGDIQELMQSDVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLESIILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYNRKRTFVDSFLLGVLQPAPPGSSNRPEVFSIGVVANNTKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADLAPNGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLNKRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSASTSKLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQPRTCDIVRMEWLLRVCQKQELELKPRDLIAATEPLQQDLAECFDRHGDSYTKDIANVEELQDLLQGIELTADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFFYSPHGDEVAKLLFLQNGGRIVDDSDPQLNLGFICMSSDIDNDHFEHWLHNHSKLTTDKVLNSAWIHQCHREGILLPMHSFV
Protein: Uncharacterized protein (Q583E3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGAVPSRESLSRGLCRLPDYGQKHKMVLIPLTKEFFPSPDCLPLRQLFEARKDPFVHYYHTFDESFTRVQPSGDKVRSASATTSGDGNSVWHAEEFVPLNCTPEEFYDAYVTRARKSLIFDTDKQMFDLNAQDPEALRPVPCAIAFVCGPAGSLPGSDNVGRPPEKGGLYMHGCDDDAEFMKDAAEGEGEDDGVGGAAEGKSVLEESVVVCGLRLRVVGFVGDVNGILPRSCDDNLGEGPFQLQVFLNKSVGDHNFVHAFISAIYTYVAQWREALAGVMSVKDEARLAKQRRDKMRDGGLTDSPDIDSNRDLLLPPVGSVVIASRRANVPMLCFQRVLRATLSRLFAVAEADKATDPNGSFCSKCGNRSDHVSWLNKVGTEEPLNAPREDNETPEECATVFGPKTNFGMGDDLHMWLDNDVLFTRISQDAATRAVGCIARRMDCPDCITDIVRPKYFEMQEISDRDASTARTRTTVSVTETVGSLPPAIDARTHNTLNEAPVSILASIPSRGTESSQNGNSTAVAAAAAALKPHRKLNDRPGGAVVVEAWPEGGIDLVDFADSEDSTKDQQLHLYWVVGHSKEAQRTATVALSSWKANGRSVVIGRTCCSSVESGRKGSGGNKDDDDEQVSIGELIHLMVDPCQSSESQSWVIERLKFPLEELLLSELHNSCKLAREAHVDAENWIRYRDSGSEQSRPTPLLLPPDITEGNAEGSPELADAVAQLVGEGTLCLWRLSLVTGAVRVVAVTPYFLRPPRKKRSRRKVARRQRVLTKGVESSTKLTTPAPTRHLGPPMVPQQSKAKRTVTAKATTTGFLAPMTTVMGPVKTAEQGTPFPLVNYGVCKEGAVPPMPTPNFPSVGFGYVLPQQRLRTYGSPAPAHYAEPLVLTHEPQHDFPCFNQPVVGTNRPPASVLNHRVRHPPAPFTSSRSPTVDPCEFVFCDDPKDSRRGSSNRDSHRVSIPSFSTPHWDDTGVPWSYAASGERSSTTRGSSIVGNQCSPFPQSADKWLNPTNPRSGAREKVHYLPGFRSSFGGISDSDDTTACVRNRVHSVPTNLESGKDVYSDRSGVMTPSLNVWVRHGLQH
Protein: Tryptophan synthase beta chain (EC 4.2.1.20) (P9WFX9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Interaction partners:
- Tryptophan synthase alpha chain
- Indole-3-glycerol phosphate synthase
- Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- Anthranilate synthase component 1
- Anthranilate phosphoribosyltransferase
- Anthranilate synthase component 2
- Salicylate synthase
- L-threonine dehydratase biosynthetic IlvA
- Phosphoserine phosphatase SerB2
- Serine hydroxymethyltransferase 2
Sequence:
MTDLSTPDLPRMSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQALNVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKWFGLLGND
Protein: Slr1772 protein (P72765)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
Sequence:
MVGAIARWASLKIVMNPRQLTKTMNIQFLGNITTAILLAVVLQITLWPSAAQACTRILWNNNKLAVVVGRTMDWPESTEPELMVFPQGIKRNGGMLGDMLVVKDNPAQWTSKYGSVVTTVYGMGTVDGLNEKGLGMHMLYLTATDFGPRNPKKAGVQAGLWGQYLLDNAATVKEALALMNEIQPVMVALDDMKATVHLAIEDASGDSAILEYVEGKLVVHHGPEYRVMTNDPTYDQQLKFLETWDFTNATRQTPLPGNVDPKDRFVRASYYQMMLPEPKTEQEAIAGILAIARNTSVPFGAPNNIPGSLYNTEYRTAIDLTNRRYFFELTTSPNVIWVNLDQLNLAPGAPVLSLDPDNLDLSGNVTDKFTKVLKSPF
Protein: Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) (P38377)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36261528}; Multi-pass membrane protein {ECO:0000269|PubMed:36261528}. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). {ECO:0000250|UniProtKB:P61619}.
Interaction partners:
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit gamma
- Ribosomal protein L35.
- Ribosomal protein L5.
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL13
- Ribosomal protein L11
- Ribosomal protein L8.
- Small ribosomal subunit protein uS13
- Ribosomal protein L26
Sequence:
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
Protein: CRIB domain-containing protein RIC3 (ROP-interactive CRIB motif-containing protein 3) (Target of ROP protein RIC3) (F4I5N6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Functions as downstream effector of ARAC11/ROP1 to activate calcium signaling that leads to F-actin disassembly associated with exocytosis in the tip of the growing pollen tube. Counteracts the ARAC11/ROP1-RIC4 pathway, which promotes apical F-actin assembly associated with vesicle accumulation, to control actin dynamics and pollen tube apical growth.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11752391, ECO:0000269|PubMed:15824136}.
Interaction partners:
- Rac-like GTP-binding protein ARAC11
- CRIB domain-containing protein RIC4
- Interactor of constitutive active ROPs 1
- Putative F-box/kelch-repeat protein At1g13200
- Rac-like GTP-binding protein ARAC6
- Ras-related protein RABA4d
- Pollen receptor-like kinase 2
- Rho GTPase-activating protein REN1
- Villin-5
- Rac-like GTP-binding protein ARAC1
Sequence:
MATVKGLLKGLRYITQIFDEEKDKDMQIGFPTDVKHVAHIGSDGPATNVPSWMGDFKPQENENGQVVSRADANNNQIGEGVGLQELLPPTDKPKHKKTRRKSETVSQNGSPPRRNSSASASDMQPKNTRRHHRSRHGSIDSSNDPSVRRRRVVSVTTNDMEGSYPLSDSSTHSRKSTSRHRKPKGSGGGELSMKKTKGKTENPIVESVDTCNDNNISDKE
Protein: Thymopoietin a (Q5RGX2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSEFLEDPSVLTKDKLKSALLANNVALPNGDQRKDVYVQLYLKNLTVQNKKSSGSPDVFSSDEELPPAPVVSNRSRSGRKATRKTDKVRPDDVDVTELSNEGLKDLLLKYGLNAGPIVASTRKVYEKRLQKLLDQGPPVAVALPSETSQTDGNQNGNNDSDQYSDREEEPVAPAPVTVPEPEVEAELIPVVERPVRSRGKTPVTSRTRSGQHTRVEKVSAIDQTPRAVERDVLKEIFPTENLNTPTGISATCRRPIRGAAGRPLIDTWLNESRQRLSDLKQTTSSSSFSSTSSYTESRSVPRVSSIPLSASKSTAPPTVKSRSRRSLPVWVQLVLLSAVAGFLFFIYQAMETNDVGLFKQSGTDDSTSK
Protein: Phospholipase (EC 3.1.4.4) (A0A1D8PF62)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- diacylglycerol cholinephosphotransferase
- Phosphatidate phosphatase
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Phosphatidate cytidylyltransferase
- PNPLA domain-containing protein
- Lysophospholipid acyltransferase
- Lysophosphatidic acid acyltransferase
- Phosphatidylethanolamine N-methyltransferase
Sequence:
MSPTAEQPISPLDENPLDENVNNSKLKASSANDKEDGSYNLKAVQQDGTIDDNDALRKSSDIDRIFRSVHSGPILPEHRSPSPNTRDDSSQVIGNPLSFYYSNDDKESRYDEDRSQGQSLGKSKYPEDEQQLPNRFELVDDEDINKAPPRKESSRPTHSRSATLSGFMQSRILGRSTSTNQEMPNTEPEFANLHDALHPREDSTKSGRFIKTLRRFNRRKTKDKRQSTMTAEFDELNDESENATIERAEKLLAGMSTGAPAINLMASCLLEDEHGITRAPLLLSVLGFKLSDVTPKETSRNRRFRIDLEYGIDKHRMKWSIERNATDLAYLAYKLERTRIVSRVVGNKSQPLPRLPIPPIRKLDNKRSKKTKSVLSDSRARDDRMSVPDINDNHSLSPVPSALSRVRSRLGSITSVGSLEKHPELLELRRKKNAQFMKDVESYLKELIEITELKTSANILFTFFELSPLSSLLSYESGYTGKQGPVHIGGTAKAQGWRVGHFKVNDLKGIYERRVEKWMLVRNSYITYVSDINSTTPLDVFLVDSDFKISARNLEIANRDDDDSLFDNSSVAQQQMHENENKFFPHLKITLENRERKLVMSPKSQREHSLWIDSLRTMQNSTIWSQNKRFDSFAPVRENCFAQWFVDARDYFWAVSTALEMAKDTIMIHDWWLSPELYLRRPANGNQQYRIDRLLQRKAKEGVKIFVIIYRNVGTTVATDSLYTKHSILSLDEENIHVIRSPNQLLQNTFFWAHHEKLCIIDHTYAFLGGIDLCYGRYDTPDHALTDDSGVDFSNIAQDDRITAENFANFQVFVGKDYSNPRVKDFSELEKPYESMYNRNIVPRMPWHDVHMYTCGQTARDLSRHFVQRWNYLIRQKRPSRLTPLLLPPSDLTEEEVLAHGLDGTCEVQLLRSSGNWSLGLKEHEQSIQNAYLKLIETSEHFVYIENQFFVTACFIDGTEIKNRIGDALVDRIIRAHREGTNWKAIIVIPLMPGFEAQVDEAEGSSVRVIMQCQYMSISRGETSIFAKLRKKGIDPDQYIQFFSLRKWGRIGSNRTLVTEQLYIHAKTMIVDDRSVIIGSANINERSMRGLRDSEVAAVVRDKEMVKSKMNGKPYMAAKFAHTLRMRLMREHLGVNIDIVDVVERRFKRFENFAASEEGKKFATNKFRNPENRTLSAMVEIASRDILQQPEGTRRWKEFIHVSKYDAEIAEVNFEEEDTSLPPPLFLPISFNNRTGPFEANKGVRDSKKHSYDNRVQNSESHKKDVYGEGLDKYRSKLAKRARVSSGKFLNELSLLAMETNPTGSFLPDFDSVRNFLESDDCHMSGEMDDESEDIIAERNKERWMLLKKISYLQRLAAREKSMNDTENQKRAKLGLPLLSKTGNAVNGNESQELPVSATLPISEGIDTDFSLDKEFPTVSLSEPAARDIINNLTTPDAAVSNFVDPYEFEDPIDPDFYEARWNEFARRNTDIYRMVFHCQPDDVVGRWSEYTHFTKLQSMFMKAQDTDTDQGQSAENYSDEKVEAGDNQEPRRANNSKLEKIDEASEDEYGLLGKAPPERGLENQNKSEQETNLRAKLSRRVSTFAGVTENRDKHFSDKAAPKSEGELQGGEKTSTEEEESEESGTPTDKPSATAGTVPASKTRKRARTYLARRKIQTGDVVYDKNSAERLLNAVQGHLVYFPAEWLSVELRNNNWFYNTDRLPPMEIYD
Protein: Pbx1b homeodomain protein (Pre-B-cell leukemia homeobox 1a) (Q9I9B6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDDQPRLMHSSHGVGMAGHPGLAQHMQDGTGGADDEGRKQDIGNILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPPDAQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAAAGGVGSDNSAEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANMYAARTAANATSVSTHGSQANSPSTPNSAGGYSSPCYQSDRRIQ
Protein: EvC complex member EVC (Ellis-van Creveld syndrome protein homolog) (P57680)
Organism: Mus musculus (Mouse)
Function: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21356043}; Single-pass membrane protein {ECO:0000269|PubMed:21356043}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17660199}. Cell projection, cilium {ECO:0000269|PubMed:21356043}. Cell projection, cilium membrane {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}. Note=EVC2 is required for the localization of EVC at the base of primary cilia (PubMed:21356043). The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}.
Interaction partners:
- Limbin
- Protein smoothened
- Suppressor of fused homolog
Sequence:
MTCTKDARLQLGREALQAAPTLLVPAVLLGGVLGLGLGLWLGCRASHLRARLQKDDRKRLLGSSEPPAQSLRDTGSQAKARRRQRETTRDEDAPEVCEPSLSGNITAFALKARVVYPINQKFRPLADGSSHPSLHENLTQAAAILPHLPHQPAEASPASSLGSLSQAGKEDGSSSSSMRSTYSDDRILQCAFLRVGSFPEILACESVDIDLCVCSLHLKDLLQVDTALRQEKHLMFIQILKACLLDFFPKKKPDDELCQKVLSKQEHDLEELEKGLQARLANTEMLGTGDSGYVSLADVERKERELSEQLIDNMGAFWKQMESIQPTLMDQFKCSSSKARQFMMTLTGRMIVAEGLLHDSQDLHVLDTLERTMGRSHLARMVEFLRTQIQEETKCRLAAISRGLELLTVQGQLSGRQKEELLTQQHKAFWEEAERFGREFTQRGKDLVQASQARQAEAAAELTQTQEEERRSFLADSQLTSDPGEFLKAFHEVLERQRLTRSDQEGDEDTRITEAMAALCQELYCSTMGTFQKFVDSLFLKTLPEVTSLPVAECETLRQQVQEQAARQLGQADRFRRRQWGLLCDLLEQDKRVWLEEGTLSTVLQRQLRDHHESTIHGVLSRFSGLSEESSRGILQGHELLLCSALRRLALRGTTITALAQMRLSGKKRLLQELHEQLALEQGVSPCLEEHQWQLLRALEARIQEEAARLEDEAQQTGLRLQQQLLAEAQEAGRLLQLHMERVIGQALLVHARNVASKGRTREKEDFKRTLVETVVESVYVTSTSVNRLVQAHYQAVGKLLQAHEEQLLQRLKTLQGERINAYKLWKKQEFSDPSLESQTADGTHGASQGVQQRMLSQQKRLLDQFTKHQQGRLNSQRQKAQELDQLQAQLETQLQEAEQTLISELSTLARVPLPENKPFSNKRGLPEKPVRTKRKKPPPREREDLGTPNDDHLALADHTTGPLSTTYSASPPIRVHSGGRLDQQDSEAGDGESTSKILQKGSNL
Protein: Hydrogenase maturation factor HypC (Chaperone-type protein HypC) (Hydrogenase accessory chaperone HypC) (P0AAM3)
Organism: Escherichia coli (strain K12)
Function: Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HypC delivers iron-bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand. Involved in the maturation of the hydrogenase 3. Also participates in the maturation of hydrogenase 1.
Interaction partners:
- Carbamoyl dehydratase HypE
- Hydrogenase maturation factor HypB
- Hydrogenase maturation factor HypD
- Hydrogenase maturation factor HypA
- Carbamoyltransferase HypF
- Formate hydrogenlyase subunit 5
- Hydrogenase maturation factor HybF
- Hydrogenase 3 maturation protease
- Hydrogenase-2 large chain
- Hydrogenase-1 large chain
Sequence:
MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPDVGALLYGEEK
Protein: Terpene synthase 17 (SlTPS17) ((+)-valencene synthase TPS17) (EC 4.2.3.73) ((E)-beta-farnesene synthase TPS17) (EC 4.2.3.47) ((E)-beta-ocimene synthase TPS17) (EC 4.2.3.106) ((E)-gamma-bisabolene synthase TPS17) (EC 4.2.3.-) ((Z)-beta-ocimene synthase TPS17) (EC 4.2.3.-) ((Z)-gamma-bisabolene synthase TPS17) (EC 4.2.3.-) (Alpha-bergamotene synthase TPS17) (EC 4.2.3.54, EC 4.2.3.81) (Beta-bisabolene synthase TPS17) (EC 4.2.3.-) (Beta-myrcene synthase TPS17) (EC 4.2.3.15) (Gamma-gurjunene synthase TPS17) (EC 4.2.3.-) (Gamma-terpinene synthase TPS17) (EC 4.2.3.114) (Limonene synthase TPS17) (EC 4.2.3.-) (Terpinolene synthase TPS17) (EC 4.2.3.113) (G5CV52)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into gamma-gurjunene, (E)-beta-farnesene and (+)-valencene, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into (E)-alpha-bergamotene and (Z)-gamma-bisabolene as well as beta-bisabolene, (Z)-alpha-bergamotene and (E)-gamma-bisabolene to a lower extent. Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, (E)-beta-ocimene, limonene, terpinolene, gamma-terpinene and (Z)-beta-ocimene.
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Alpha-farnesene synthase-like
- Sesquiterpene synthase 9
- Uncharacterized protein
- Squalene synthase
- Squalene synthase
- Dehydrodolichyl diphosphate synthase CPT3
- Protein farnesyltransferase subunit beta
- Farnesyl pyrophosphate synthase
Sequence:
MELCTQTVAADHEVIITRRSGSHHPTLWGDHFLAYADLRGANEGEEKQNEDLKEEVRKMLVMAPSKSLEKLELINTIQCLGLGYHFQSEIDESLSYMYTHYEEYSIGDLHAIALCFRLLRQQGYYVSCDAFKKFTNDQGNFKEELVKDVEGMLSLYEAAQFRVHGEQILDEALNFTIAQLKQILPKLSNSQLAQQITNALKYPIKDGIVRVETRKYISFYQQNQNHNEVLLNFAKLDFNILQTLHKKELSDMTRWWKKMELVNTLPYARDRLVECYFWCLGTYFEPQYSVARKMLTKISFYISIIDDTYDIYGKLDELTLFTQAIERWNIDASEQLPLYMKIIYRDLLDVYDEIEKELANENKSFLVNYSINEMKKVVRGYFQEAKWYYGKKVPTMEQYMKNGISTSAYILLTTTSWLAMGNVATKDAFDWVATEPPIVVASCYIIRLLNDLVSHEEEQKRGNAASAVECYMNEYSVTKEEAHIKIRDIIENYWKDLNEEYFKVDMIIIPRVLLMCIINLTRVAEFIYKDEDAYTFSKNNLKDVISDILVDPII
Protein: Uncharacterized protein (Q586T7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCAFCAFTRGVLGRRTFLRTRLRRNIYIPSSTIRIVFMTQEHGSEEGTLNALRTALSSGKADSIRTLDENAVLLHHKQAVPELLQLCNSVGGSHSMSLLNTAWKLLLSVAALKDVTAGLYCKILHFMLSQLQHHIFSHDWSDPKQIKLTTFVASYLVSTVRKHPSFAVRDEAFVNSILDLHITTVFTLVTTENGEAAQQLQKQVGVRLLGTLGALGGTLGEQQVGEDGGWSPLLVKCLRTAPSEVATSLGDEVDVDSITAVAAMTAMLAMARSMVPLLEKPASLERLLEVSLLWLPDMTVVLVEQDSGACALHKRVSQLAKELPREVYYAGRGHEVEAMESSQELDLGAQLMLLLRSTVRRSVQLDQQDGNLEKNGSGFMCGVLQRFRVFSILLAALLVPNDTSAARVLLVWEAALHALPGALRRTLGEELLLLGEGQLCALRRSHTLQHDKVETLRRFLNLLAVLTAEICRLLRVPPEVLTGTRNDSTVGSVPPEGPTFHRMVSILYHQSRVYQWWWEEMLVLSGNERAAGAAVSATPPGTAVSALHDELQSAFSHNEGDQKQRLCMVLTSVPGKLVEILRQCNHTSGSRSINVVPLFSVATRAIEALYNSADSSDDVRVCARFVAAEIVAVAGLLQCGDSAYSTLLHRLVQISFKPLESGSDLHGSRLSGEPADRSQCVEGILRYHAAVCLYLFAQRETSVPVAELCPGGSVATALRQILEGKGLTTGGDVTMHSCEALLAPQVTVWQMLFPHLGRVPTSETKAIKGGSQGSQLTVDASSDSSHCSSQSTPGRLLLPLQKCEETLRLFLESQESVGRSLTREETETLTRVEQLVAAAAVMLRPDIKSNGQGRFVSSEGPSGPF
Protein: GH28569p (Q961E6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPFKHQTRLENVVEAGRGEAEEDEELEEDEMEDRANNNNQQELSPLIKAPANGLRRSVTPPNCCASEGGDCEKPDEPESKRIKLQVGEKAEDKQVENEESPSNGTESHDLEKLEKNDDKTDPTNNPKSPQPSQISSDDEMEEDDEDEDEEDEDEEVQVEAPHSSALATPPTATTPLSPDSAATAGQLFDSSNSSDESSMKKAQMSACHALEKMSSNVGSDENNQRLAEESQEDEAEEDPEEEDSDDDEMPLQQRQQQQRQRVAPQNVLSGPSVAGHHPAPAHPPMATKASKKQTPPAPPTAAATTTASATTNCELQIKKEIA