Protein: Polyketide synthase/nonribosomal peptide synthetase hybrid RzxB (Q4KCD8)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Cytochrome P450 monooxygenase
- AMP-binding enzyme
- [acyl-carrier-protein] S-malonyltransferase
- Thioesterase PltG
- S-adenosylmethionine-dependent methyltransferase
- Enantio-pyochelin biosynthetic protein PchC
- Thioesterase
- Thioesterase domain protein
- Polyketide synthase/nonribosomal peptide synthetase hybrid RzxA
- Polyketide synthase RzxD
Sequence:
MSDNNATNDGPQSTPRAAQPADRTAEAALIAGWNQTHYEYPLDQCLQQLIEQQVQRSPDAVAVCFDDQTLSFCQLNRRANRLAHYLRELGIGPDSLVGVQMERSLELMVALLAILKAGGAYLPLDPGYPEERLALIIDDAAVSVVLTQQRFEHRLKAQAVEVICLDDPASEELHPSEDNPASINSPGDLAYVIYTSGSTGRPKGCMLPHKAICNRLLWMQRHYQVGPAERILQKTPFTFDVSVWELFLPLLSGACLVMAKPEGHKDAHYLVQIIQAQQITICHFVPSMLRFFLKHPAVAECRSLSQVFVSGEALTHDLLLQFCSRLDARLHNLYGPTEAAVDVTWWPAEPRPDQRVPIGRPIDNIQIHILDAESHPVPIGQTGELCIGGVGLARGYLNRPELTAEKFIRDPFCAQPDARLYRTGDEARFLDDGQIEVLGRFDSQVKLRGFRIELGEIENTLKSHPGISDAVVLVQDPGSEDPKLVAYVVAQGLDKKTIRDFVKARLPEYMTPNRVQFVEQIPVTAHGKTDRQALLAADGIAPAGVRAPALEPQALSAWLQQYFIEALGIEALGVDDDLFDQGATSFTLVQAVHSIHQQYQVTLAVEVFLQQPTLAAVIAYILDQKTVTADQNCVAQALPAPRASIQESICLQAVHFDPGAYRRTTDVAASSLQRLGGLLSLLREVTLEGKGKYLYSSAGGLNAIQCYLYVAQGQVEGLPAGAWYYQPRLNRLLPVSMPAELDAHALAASPLAAAGLALFLVAEMAAIEPIYNHAAPALLVLEAGYIEQLLLSRQADFGIALAPAYGVDVATLGPLLQLQPSHRVLHCLMPAHASVLSSGQPGALFADFLAGNNNGFDLPGKDALEQLHRQQRQIRRDLAEQGDGVIELPAAPISVDALQLRAAKRQYGGEALSVAQLSRLLSLLRAEPDSGCLYHAEPALPLKIYLHLAGPTDQSPGQAQCPPPGIYRYHSDRHCLSRIGEAEPQAFNGSYTPFNRKHAQQARLRIFIIGARSAAYGADSRYFNLLQAGRIGQLLLDHQTEFGIGLCPIGSMYFDKVRGAFDLEEGDELLHSFVGGTVSQRLPLGWPRLERQADEQPGAAPEGEGALAIIGISGRYPGAANPRELWQNLSAGRSSIHSVSGQALLAGEPITADAPQWAVGTLADKQLFDPLLFNITPAEAKTLDPQERLFLQTVWHCLENSGYTAAGLRRTAQRVGVFVGAMWGDYQHHRPGQQGERATSFHSAIANRVSYFNDFNGPSVVFDTSCSSAMTALHFACASIRRGECQAAIVGGVNLISHPSHLELLTSLQLLSAEGQSHPFGRNANGWVAGEGVGALLIRPLEAARREGDQILGVIRATAISHSGKTFRYGTPSAESQAASMRQALEQAGLSAEAIGYVEAAAPGASLADGAEFAALGKVFAERLGQTPLKVGSIKANIGHLESASALSQITKVLLQLQHGQIAPTLGCHPLSPLIGQGPGNLAIADTLSPWQGPRRALINAFGASGSGGHLILEAAPPVSAPGKAVGPWLFPFSAASQAQLEQLLAAFADDLQAGRLSAASLGDISYSLCVGRVAQAQRVVLVADSEAQLLALLNAAHGDSVLRGRLDRAAPAPTSEADLRGLDRQALNAIGRRWLAGETELLAIARHDCRRVALAAYPFAAIDCHIGHSPRGDMVAPPVPDEGLQTALEGYLKQHFSKVSAIPEASIDSLETFDRYGLTSLMITELNQRLAQGFGELSSTLFFEHQSIHALAIWFAAEHPSRSRQLLGLQAPVASAAAPRQTASGPDIERRQACDEPIAIIGLAGRFPGAPDIERFWDNLKNGVDSISEIPAERWAHLQYYSRDRSLKGKINSKWGGFIDDVDRFDPLFFNISPRDAERMDPQERIFLETAWHTLEDAGYDRAALQRHYQGKMGVFVGVMHGEYLLYTRSAAADCTDDAVDASFGSIANRVSYVFDCTGPSMAIDTICSSSLTALHLAVQSLKRGECRVALAGGVNLSLHPNKYFIQSQLTMSSSDGRCRSFGEGGDGFVPGEGAGAVLLKPLSQAQADGDNIYGVIRATSVNHNGKTHGYTVPSPNAQGAMIAESLEKAGMNPRELSYIEAHGTGTALGDPIEISGLQQGFARRSAALGSEPAPAQQCALGSAKSNIGHLESAAGIAGVAKVLLQLKHRQLAPSLHSSRLNPGIAFDQSPFHIPQQLQEWRRPRLNLDGREREYPLAASVSSFGSGGSNGHVIIAQYLAPERDEPVAGQPAIIVLSARTPSQLQQQVERLQQFLQRREQQGQLPRLADLAFTLQQGREALEYRLGFSAASFSALQERLAQGLAQLLKAPEHFGCFDGLHLGRVQENKAAMAVLAHDEDMAATLAAWADKGKHQKLLELWGKGLNFDWALLGMPMGSVRRISLPGYPFARERIWVSGDVQFPLQVESLGEARLHPLLHRNVSDLAQQKFTAVFSGAEFFLRDHRVGRQKVLPGVAYLEMAREALSRSLGDRASSATLSLCHLVWSQPLTLSEQGTEPATLEIHINSLAPQRLTFEIRQQPQRTLCCQGEALLHNNRVQAPASLASLQGAIHGHRLDAEGLYRLFDSIDIHYGPSHRAVRELRIDGGQVLAQIQLPPSLSAGHGQFVLHPSLMDAALQSTLGLLVADQLDQGLAPQLEHTAVPFALEQLQHSGAALGERIWAWVRPGAQRREAGQSSFDIDIYNHQGEHCVALQGFVLRELKAPSPLQLMLDDPPRTDAYLLQRWRRVTVQQVPSSGARLLLIANDPQGLQQLTARYPQAATLLLDGSETSDRIATLLAEASPLEHLLWLAPSAGAADTSADGMIRAQQSGVLGCFRLIKALLALGLDQQPLAWTVITRATLTVFAEASSLHQAASEPVAPAHASVHGLIGVMAKEYSHWPVCLLDLPAGDSWPGQDLLSLPADPRGEALAWRQGVWHRAYLAPCLVPADSAAEVGSLYRDAGVYLVVGGAGGIGRLWSEHLIRTRGARIIWLGRREQDSRIDAAISELARLGPAPRYIRADAGNHAALQQAVSQVLAEHGQIHGVIHAAIQLEDQSLARMVGQKFAAGLAAKVDVCARLAEVFEHQPLDFMLFFSSLQSFTRSAGQSNYAAGCTFKNAFAHYLAQQRGYPVKVINWGYWGEVGSVASDDYRRRMAAVGLGSIDGESAMQALDVLLGARDDGAPLSQLTFLRTSQRLSDTFSQLGLAQHPGGTFGVYGEVRPPAYPALIERLQRNLQPSNQQVRHATGQLQAQRAVIDELQRGLLYAQLQHLGCFSQDGESVAQMRQRIGLLPMYQRWFDQSLEELAQYGYVELAGDSWRASHPQPLMLEQLWHEWDRQQPGWLQYPGLKAETLLAAATLRELPQILDGRIAATDILFPDASMSRVEGIYKHNPVSDFFNEVLLDALLEFVRARLEQSPQTPIRILEIGAGTGGTSARAFEKLRPFQAQIAEYCYTDVSQAFLIHAQQAYGPQTPYLRYQLFDVHQPLAAQGIQPDAYDLVIATNVLHATPDLRRALQNAKAALKHNGLLLINEIARNGLFTHLTFGLLKGWWLFDDPQLRLPGGPALAPAQWKQVLESEGYRQVYFPALAEHDLGQQIVIAQSNGLVWQEPIDTAQAPAIAPIKRHQPAAQASRAPQPGVIAAPLGEVSSTRLKAETVRYLKQVIGGLFKIEPEQIDAREALETYGIDSILVVQLTNLLRDKLTGISSTLFFEYQTVDALAEHFVATQQDRLKTLLGLGQVPSNPSPTATASVEPAAPSRFRVMLPDTLPTAGRDSDVAIVGLAGRYAQSDNVRELWQHLKAAESCIAQVPADRWDWRQYFDRTPGTEGRVYSPWGGFIGQIDQFDPLFFHLSPREALKMDPQERLFLEEAYHCISDAGYTPARLAERQRVGVFVGVMNGTYSRQSSYWSVANRVSYQFNFQGPSLAVDTACSSSLTALHLAVESLHSGVSDCVLVGGVSLLVDPVHYIGLSEMKMLSAGQHCKAFGADADGFVAGEGVGAMLLKPLAQAEADGDRIYGVIKGSMINAGGKTNGYTVPNPLAQSRLVVDSLARAGVDPRAVSYVEAHGTGTALGDPIEIAGLARAFNADAATPLKQYCAIGSIKSNIGHCESAAGIAGITKVLLQLQHRQLVPSLHAATANPHIDFANSPFVVQQSLAQWSRPQVLIDGVQQTFKRIATVSSFGAGGANAHVVIEEYEDLRVRPQITVNHEQPALILLSAKTGEQLLQQARLLREELEQGVLVDADLPALAFTLQVAREAMEHRHGWQVACLAQLHKCLGDFIDHGATQARSRLKPDTQAPSLDMASALQRGEQQGLLDAWLDGATLDWRLMYPQGTPAPLSLPGYPFARERYWQPTQGAATAIATGVEHLHPLLHRNVSDLRGLRYLSRFSGDESVLAEHRVNGQAVLAGAAMIVMIQAALTDALGGAVPAGRGLVISDLSWRQPFSVDAANNGELFLELSMPAAGDYRIGIYAYDQAAQLQLHCQARASTAEVQAAWLDFSSLGAQVVDVEACYQRFAAMGIEYGAGHRRLLSLVRQGDQALARIALQDPALNSGFALHPALLDAAMQGVMALLLDELEERPALLLPAGLGQCVLLADCPASLQVQIRRAPSTAPDYCFDLALFDDQGQCCAILNQLSFQPLTGASLAAGPGANIGLLCHKHWHDARPAPTAAAPGLAQQVLTLGRHQAFADLAPHLADRGIGHVAWPELDYPQAALALAEQLKPWLHSAQPCLIQLLVAADDPHGYRGLGGLLYSVSREQPALICQLIEVAPQLAAQPLLTALVAEAADPAERQLRYLQDAGTLRRQQLSWDHQPLDTAPAPWRPEGVYLITGGLGGVGTVLAREIRAAAPRARVVLCGRTPATAPSVLAKLEQLGAGVDYRAVDLASADQVEQLIAELVRDDRGLHGIIHCAGVTRDTLLAEKSIEDFAAVFAAKVDGVRHLDRYSAGLALDFFVLYSSIASVLGNPGQTDYAAANGYLDAFASLREQQVAAGTRQGRSLAINWPLWLEGGLHMSDTARRLLAQRSGIEAMASATGVQALYQALHSDEAQLMVLAGDREKLLALLNPEPALPPEAVALEGDDLLAWLRQLLAKTLKIDPARLDSEVPFEHYGIDSLMIMEMTAVLEKCFGALSKTLFFQYPSLQGLAEHLATRPVRTPPQSALITSLRDLFASALDLVPQQIDEQQCFEAYGLDSLQIVELTRRLQQRFGALPPGLLFEHSSLQALARYLTARAAKAPAEAGNPSQEIQRRLFDGPLQPLLPAAQPRDDIAIIGIAGRYPEAANLEAFWQNLRQGKNSIGEIPPERWDWRDYYSNDRSLSGVHNSKWGGFIDGIDQFDPLFFNISPLEAELIDPQERLFLQTAWSAMEDAGYSRQLGAEQADPALQVGVYAGVMYNEYQLLGAEASLRGQRMGFAGSSASIANRVSFCLNLQGPSLAVDSMCSSSLTALHLACQDLHSGRTAMAIAGGVNLTLHPNKYLMLSSGQFISNQGQCASFGEGGDGYVPGEGVGAVVLKRLADAERDGDQVYGLIKGSYLNHGGKNTGYSVPDPRAQQAAISGALKDAKVDPAAISYIEAHGTGTRLGDPIEIAGLASALGPRTPAQTCWIGSVKSNIGHCEAAAGIAGLTKVLLQLKHEKIVPSLHSRTLNPFIDFAATPFEVNQQLRDWPQPWHQGQPLPRIAGLSSFGAGGSNAHLIVAQYLSKRPVPAPDGQPQMILLSAREPEQLRQIASRLLARLEQAPVAASLAAVAWTLQVGREAMEHRAALITSSLASLLQALRALANDDCSDWICGDTHSGSETLQAFKLRYRNSWHEQLAQLFAKGERQQLLALWSAGLRIDWNALRAASGERPPRISLPTYPFATSRYWAPVATTGLPSATTTLHPLLHRNSSTLDRQQFTSLFRGDEPWLLDHLVQGRKTLPGAACLEIIRAAASHARAPGEAGGMVIEQLHWLAPWTLESAPRGLRVTLQTVDDQLAVTLLSDDGEQPLVHCQARVTAEAAPVAEPLDLGYWRNRPWQRRLDRDDVYRLFDAMGLAYGPSHRGIQQLLIAEQGGRRQVLAQLHLEAVAGASDCWLEPGITDSALQAAVGMLLPLDSEPAEPLPLMLPFALQRLEIMAPCARRMWALLRSDSGDHPSQRIDIELSDDQGRLCARWVGFAARALAVAAPKAPTPAIEQLLTPIWSVVDEQLVGGGTGSNPPRDRQGTMLIFGATPCRHQALAGLYPQARLVDGCPVNYDAQLQAGPELADVMWLAPPVDGSEDLIAAQDPGVLALFRLIKALLRQGYGRRPLRLTLVTAQAISLRPGEPSHVAHAAVHGLAGSLAKEYPHWQVHLADLEDGQLPRLASAPFAAVRCGEVLALRQGQWWFRQLARVQADVAPPRLPVYRDGGVYLVIGGAGGIGAVWSRQMISRHRARVVWIGRRERDAQIAAKLDELTAVSLMHEAPAPVYLQVDATDATQLATAKQRITERFGPINGVVHAAIVLKDQSLANMDEATFSQVLNAKVATSVALAQVFGDSAATLDFVLFFASMMSFTSAAGQSNYAAGCTFADAFADQLRAQWACPVKVINWGYWGDVGSVSDPRYRERMSALGLGSIEPEEGLRALDQLLAGGLDQLALLKLLHTPQVDGFDSLAGLLGNEQIVLCADNPGAMAAMQDRLQHRLAALAAIT