wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin family member 20A (D6R9E4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
Sequence:
MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTY
Protein: Sigma factor (O86856)
Organism: Streptomyces coelicolor
Interaction partners:
Sequence:
MAGGASHDGVSDQELLARHVEGDPDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAYRAAHTFRGQAAVTTWLHRITVNACLDRARKAASRKTAPVDDTERLEQLLEPHESASAPAERNDLHRQLLEALGTLPADQRAAFVFVDMQGYPVAEAARILDVPAGTIKSRCARGRARLLPLLTHLRPDGSGESRKPGPERNRTHGASVPPAAGPSEAGPGDSTAVKGGGGRA
Protein: Terminal uridylyl transferase 7 (X6R3Q3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGNEHISVHPENSDCIQADVNSDDYKGDKVYHPETGRKNEKEKVGRKGKHLLTVDQKRGEHVVCGSTRNNESESTLDLEGFQNPTAKECEGLATLDNKADLDGESTEGTEELEDSLNHFTHSVQGQTSEMIPSDEEEEDDEEEEEEEEPRLTINQREDEDGMANEDELDNTYTGSGDEDALSEEDDELGEAAKYEDVKECGKHVERALLVELNKISLKEENVCEEKNSPVDQSDFFYEFSKLIFTKGKSPTVVCSLCKREGHLKKDCPEDFKRIQLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRICGKIGHFMKDCPMRRKVRRRRDQEDALNQRYPENKEKRSKEDKEIHNKYTEREVSTKEDKPIQCTPQKAKPMRAAADLGREKILRPPVEKWKRQDDKDLREKRCFICGREGHIKKECPQFKGSSGSLSSKYMTQGKASAKRTQQES
Protein: Periplasmic nitrate reductase (EC 1.9.6.1) (P33937)
Organism: Escherichia coli (strain K12)
Function: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
Subcellular location: Periplasm {ECO:0000255|HAMAP-Rule:MF_01630, ECO:0000269|PubMed:10234835}.
Interaction partners:
- Chaperone NapD
- Ferredoxin-type protein NapH
- Ferredoxin-type protein NapF
- Periplasmic nitrate reductase, electron transfer subunit
- Cytochrome c-type protein NapC
- Ferredoxin-type protein NapG
- Nitrite reductase large subunit
- Cytochrome c-552
- Respiratory nitrate reductase 1 alpha chain
- Respiratory nitrate reductase 1 beta chain
Sequence:
MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKNGKYDKEGEFTPITWDQAFDVMEEKFKTALKEKGPESIGMFGSGQWTIWEGYAASKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGANMAEMHPILWSRITNRRLSNQNVTVAVLSTYQHRSFELADNGIIFTPQSDLVILNYIANYIIQNNAINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYTLEKTAEMTGVPKDQLEQLAQLYADPNKKVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFAHRLPADMVVTNEKHRDICEKKWNIPSGTIPAKIGLHAVAQDRALKDGKLNVYWTMCTNNMQAGPNINEERMPGWRDPRNFIIVSDPYPTVSALAADLILPTAMWVEKEGAYGNAERRTQFWRQQVQAPGEAKSDLWQLVQFSRRFKTEEVWPEDLLAKKPELRGKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHKARGLRWPVVNGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAEAPDEEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARDLRRGDKVKVVSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNKLTLDATDPLSKETDFKKCAVKLEKV
Protein: Sodium/hydrogen exchanger (Q80U52)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
GARRGWRLAPVRRGVCGPRARPLMRPLWLLFAVSFFGWTGALDGSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPDNERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTESATASAPRRFMGNSSEDALDRELTFGDHELVIRGTRLVLPMDDSEPALNSLDDTRHSPA
Protein: C6H2-type domain-containing protein (Q57ZN7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQRQCDGCNESASSFQCPLCQAELITDRGFFCGQECFAKNWLQHRRTFHKSGVVRAKQPRGATTGNEGDTANGNSAAATNGDETQLRKKKRKGEKIPGREQEENKKDDKLPARPVVGPWTPLPRGDDEGRVEPQLLPGVPRAIIGGASSERSVAFWSAAHAAASHIVTELLHKPQLRDEADSEPLKVLVITADALGAHAMAWACRCSGLGHLMQLVVKSIEASSPEVVPFNYFGGERRVVITTQEIVGNLCDGSAAAWFSTPNNLLVTLPGVKDAGKFQSVHMRALFFLYSRETGESMREELPGEEEEEITHFVKPLLHVPVQLHSLFDASGVTNTNQGEKGDDEKKTKKARLFRFDNNVSTSLARGDLRGALQHLVRLYSTERSAFEEVLANSFLASLGAASVAHAHHVLAYVLRELVDHSSRFKASQGATLKDMAIRALTRVIGLIQPIVAEDGTQHCNTTAAASAESGSTVDGFKDNAHSGEGDATECKFPPPSEFERKKYFNHYSSAPNLALQATLCYLYPYTTVGVIDAWGAAWGVKKTLKGPEALIQMDKARKDAVLRLEGRYGTKLGPSFAKYLVVLMHFLYDAVAGYSLAVEDVEKRTLWSLTLQSDVGPLRSFLSNCFLLQEGKPALKKKPTLSARKTTPSADELRELRRMLPVRTGSVVRESVSLPWVDLPIVMNRELRVKQLQQQAVEEILMAMPRKPRPMYIGDVGNLVGRWFRFNARFDGVLGVSLMDFLIQHPEAFRVVGDLVTRRTAGTCNSVPIRFKDDSGDDDDDDNEEPDKSRRAKDRALLTGAKSGSKGGSGKELSARARKKAAAKEFNKSRFNRNYKPLDPSAKVPGYVRHAPRKVKGRGRKANKRNTKRG
Protein: Integrin beta-like protein D (Q54JA4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Implicated in cellular adhesion.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFSFVVKLLFFIYFLITFSNASHIRFGTFKWQPTTQYNEIQFTLDLGFRTSAWFSNLPQKNDFIKISFNFGDNVVSTYQLILTTVDSKDDWFTGTSVFSHTYPTLEVGKTANYTAFYSLCCRISTLLNEKDGDFTIKSLVQIDNSNSLDKINWSPVSGMVPIYPVTYGRNNNFNIPASDQHLRPGEYSNLVFTFGEAKPDGMTLDKNTGMVYFMPSSVGLYCAKVIITDKNGAYITLDFILQSEIQNGFCHHQCNNSGEICTKNSDCINCGNLVYNKTQDACLSTKPIFIYPPTPKPNQTQTFVIGEQNEGFNVSCTTDAIGLNTTIQPVGFPIGFITKILEIGPKSTINLLWFPTSFQDYGTYVKYIVCTDSLIKITTSIEIIIKKPDCSNGGFRDKGICVCPKNFTSESDCLDCSKGYYGEKCIAVPLCVNGVSNSGILGDGKCYCNNGWIGDDCSISNSQSCGSLKSGVVSSSIMEQSYINPVGIQVYLANNQKYQIQVNIKIPEKNKLIDVYFLIDINQNTQNEFNNILSQLNDAKTKILELSPESVSFGLGIIDENGLFADLAKIPSDSIVTSLENKKWSGYNHTITGKSLSAATKAAKTPLGWRTNAFKSMIIIPRTDLPLSPIQTEIDEFKNAFIEKSIAPVVIGINVSLSNWNSTLYQCGFGAYKLSSDAQGWKNFVKTAFKETSSSVLGNGVLQNIIFKVNDNSGGLAFLKSIPENLPIDADIEVVKTLSGLSLSLPINYNSSINPSLRVCTIGYGCIDIKTNYNHPPTPNPFGISCNQNSDAIFQLEGSDPDRNILTFKFTSFLSSTEGLIKTSKGIDVSTQKDELYAGSEKFTFSPYKNYLKSLYISFIADDGCLTSDSSAKVSFSINKVNQPPECSSAIVISEFEKTVDFSFTATDFEDDDQLLILNAQFIVSSELASLEQYGQLTYIGAKVTIDTIIKKSVKILFKQTKNPLNLLVPLTFKSKDSSGLFSNLCTQTINITHTNEAPISNDGTSVTIPRSIGNPLSLLSTDIDSKSAIFTIKKVNAGKTGTFYSCTDNSCSCVAGSNDRIDITDNTKYSQIQYAKNQASLPICFTNSEPSAVPNYAFISFTSTDDEGLESNLATVIVNIVGYRTNVAPVVNKIQDYSVYQDYLDSDAHVVTGTDADIDDYNPQNANNLIAIITNPPSNGILVTVQNGSSIAIQGNAPFTHYYRPNPGYAGTDSYSYQVIDTFNAKSSIESTTITIKPINHKPNVLIDVYKFTSESGDGVIETLNTSDQDGDNVICSVISLPKQILMYDDKGVQIKSVPMVLPNNAYSFKLLDPSIITPTPFSNVLSTFSINCVDDSEKTTPKGVLSTGDVIGNVQYYYINTPPKTNISSVKLSQDSFIAFSFEGSDIESNEKLLKVLLYSLPINGKLSKSIDSNVVLTKELIGGDNTFGLDELTYTPLPGQSNWDTVDHLGPLDRISYSIVDPQGLLSPSSTISFQVRSRNPPIYLGDSDISVLQNTRFPLTIEGELGGGGLSVSIRVLSFSGRGNLSISHSMGKEGFFDKLITEYPSQQLGSTSYNFAYNPPRNQFGSNFDQIQFILFDNDIISKIYNITVNVIHVNQPPATELISYRILNQFEKEIQIDGSTINMNVNDSVLIKIYGSDIDNQTVPLVALVSNLPLRGLIYSFDDNSSDYLGREINHTSQLIPLNEDGYWYVIFIPTKGTTGDNYARVPFNVIDEKGVVSQTSTVIINVNSVNLQPKIYIGSNSNTFVGKVNLTISITNITLDDPDSVNNNISLIVSIVDDNDGDEVLPLSIIKLSFTQATPKCNPNLNLALITCIGSKKSLNASISTISVIGSISGKYRLKLFIDDLGYSAPSTVRAESHLNATGYVNIIINDPIATTQNTDNKTVLSGAIAGASAGAALLVIGLWKMIKRSSPPTDTFFDEGAFMGDVSSSPIYEKSETSYVSRIYEGADD
Protein: Superkiller protein 3 (P17883)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Antiviral protein SKI8
- Antiviral helicase SKI2
- Superkiller protein 7
- 5'-3' exoribonuclease 1
- Exosome complex component CSL4
- Exosome complex component RRP45
- ATP-dependent RNA helicase DOB1
- Exosome complex component SKI6
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein eS19A
Sequence:
MSDIKQLLKEAKQELTNRDYEETIEISEKVLKLDPDNYFAHIFLGKALSSLPASNNVSSNRNLERATNHYVSAAKLVPDNLLAWKGLFLLFRTTEVVPDILSYDEYFDLCGQYADALLKQEQSQVELINDIKLLKKTHPDCQKAFYQHLKPGSLMAETIGRHLSTPQDALLNLIKILSNIETTEIGKTLSQNRLKLKASDPDYQIKLNSFSWEIIKNSEIDQLYNQLVNILADDQKRSEIENQWLEYRIKVLKSMPLDVKKDFFTKVKEMVEDMVLVNHQSLLAWQKYFEWTDYEDLDNMDAPLIIKYFKKFPKDPLAMILYSWLSSKLSKYDIKSLESANKPPEGHKKTEKETDIKDVDETNEDEVKDRVEDEVKDRVEDEVKDQDEEAKEDEEEDLDDIEIGLLEEEVVTVLTENIVKCKNNILAHRILCQYYLLTKEYEAALPYIKNGISLIAYNIKDLGVHLPLTKREFSLDLATVYTYVDAPKDHNAALKLYDNILSGDFSNIQAKMGKGIIFIERKNWKDAMTLLTQVHEQSPNNLEVLSELSWSKAHMGYMDEALAGLDTVIKGIKGMDLRSIDFRALNLWRQAKVYIMKHASINDAKQENVKCAFKLLIQSIKILDTFAPGFSTLGDIYCHYYKDHLRAFKCYFKAFDLDAGDYTAAKYITETYASKPNWQAASSIASRLIKGEKAKAELRSNNWPFRVVGIAHLEKQEESDSIEWFQSALRVDPNDVESWVGLGQAYHACGRIEASIKVFDKAIQLRPSHTFAQYFKAISLCDVGEYLESLDILEKVCQEAATEESFQIGLVEVLMRCSLDLYSQGFLLKSVSIAKDTIERIKIIISELKCENQQVWIYLSQVLRLFIWIESKVDTLPVESLVSIFENSQFSGSEEIDSVDNIKIDTLLDSTTDDNVSIACKFLILASKYSVSDQKFTDIAGTVRASYWYNIGISELTAFITLKEPQYRDAAIFAFKKSIQLQSNTSETWIGLGIATMDINFRVSQHCFIKATALEPKATNTWFNLAMLGLKKKDTEFAQQVLNKLQSLAPQDSSPWLGMALILEEQGDIIGSSKLFAHSFILSNGRSKAAQFMYAKNVLENHINNGDDERDIETVEKLTTASIALEQFFKKSPDSQFALQCALLTLERLHHYENANELANRLIGILEKKFEKTQDERELFNFAIIKGQFARIHLGLGNFELSIENADLSQGIISESSDEKSMKTKISNHICLGLSYFFLNDFDQTLNQFQELLSISKDSKHLVVLIAKVLYDVGESDTKEIALQELTEYIATSGADLLVTLTIAAMSILDDKREDLSIILEELKALPLSKQIIDKHKDAPYLIEEITKRLYRNDTGKQVWQRSAYFFPNNLKVWERLDKNIQRRIASNGQNKVTAEEMSKLYCESKNLRSIQRGMFLCPWNVTAVKALNECF
Protein: GalNAc(5)-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase (EC 2.4.1.293) (Protein glycosylation I) (Q0P9C6)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Glucosyltransferase that adds he final branching glucose to complete the final heptasaccharide structure in the N-linked protein glycosylation pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- GalNAc-alpha-
- N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase
- N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase
- Undecaprenyl-diphosphooligosaccharide--protein glycotransferase
- Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase
- UDP-N-acetylbacillosamine N-acetyltransferase
- Protein glycosylation K
- UDP-glucose 4-epimerase
- Glycosyltransferase
- UDP-N-acetyl-alpha-D-glucosamine C6 dehydratase
Sequence:
MPKLSVIVPTFNRQVLLEKAIKSIQNQDFKDLEIIVSDDNSSDDTKSVVQNLQKDDDRIKYFLNQNYKQGPNGNKNNGLDQASGEFVTFLDDDDELLSGALSTLMQKANEGYAHVFGNCLIEKEGNLSKEFSGKGLEKDSEISKKDFLMAKFSGEFFSVFKKSLLENKRFNEEFYGNEATLWVNLYKEKSFYIHKAFRIYRIFRQDSVTLGASKNAYRVYLGYLELAKILENELRMSKDKDYKKTCASYYKMAAYYAKLAKNYKALYKCLFKSLSIKINAPALILLILSIIPNNMIEKLSKIRVALCKN
Protein: Cyclin 6 (Q8IEW8)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MNPTALREVSNLSTGSGDVKQRLAQRRSANLESCRYPYSSSAVRHGSGSLLSLRSSLYSPVGTAGKESSVSPHADRLRENNPVYCSDVIKDITTMYMESEKEAIYGQVLPSPRYLTYQPEINEKMRMILVDWLIDVHLKFKLHPETLYLTVSIVDRYLSSVNTRRTTGRYIPRSKLQLVGITAILLAAKYEEIWPPEVKECVYICANTYTRDEVIRMEREMCTELSFRFTVPTPFPFIVRLLDVVEGLERQQQTQQLSHQLQQIQSQSQSQSQQTQMQASQSQPQSLSRSRSQSRSQPRSDEECTAYVVQLRHTAFFFLDHGMLDYKCLQFSPSQQAKAALFLALVTLHMKEQGSSYVLNNDIIWTRQLQYYSKAQVRDFKACARTMLDFVSYVSTTRYQSVRRKYSSSKYGEVAKLTMPSEVPDF
Protein: Spondin-1 (F-spondin) (F1R2Z9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- 40S ribosomal protein S27
Sequence:
MMDKDGLVVLLVFLNVFLIHSDAFKRDTAERHSRSEGGFCRILRTQARSARRDGQNEFRLKVEGEPETYQPGSTYRVSLYASSPSYFRGFTLIALKEGREGVSPDDYAGTFKLIDESDTQFMTNCPPAVTESIPRRRTRIQVFWTAPPSGSGCVTLKASVVQRRIIFFQDEGSLTKRLCEKDPVAITEKPAQECCACGTAKYRVTFYGNWSEKLHPKDYPRRANHWSALIGASHTRSYVLWEYGGFASEGVKQVSEYGSPVKMEEEIRQKGDDVMTVIKTKAQWPAWQPLNIRAAPSAEFSVDRVRHLMSFLTMLGPSPDWNVGLSGEDLCTRDCGWVQKLVKDLVPWDAGTDSGVSYESPNKPSIPQERIRPLTSLDHPQSPFYDPSGGPMTPLGRVVVERIARKGEQCNTVPDTIDDIVADIAQEEKEEGDNTPETCIYSNWSPWSACSSSTCDKGRRMRQRMLKAQLDPNLPCLHTQDFEPCMGPGCSEEEASTCMMSEWISWSPCSASCGMGMRSRERYVKQFPEDGSSCTLPTEETEKCVVNDDCSPSSCVVTEWGEWEPCSVSCGLGMRRRERMMKMDASDGSPCRVQMAEAEKCMMPECNAVVCMLSPWSDWGECSVSCGVGMRTRQRMLKTPVKPGQCPDELEQVEKCMLPECPTDCMLSEWSAWSECNKSCGKGHMIRSRMVKLEPQFGGLPCPETVQRKKCKIRKCSRGSRASEKRKRQEVSDRRRAKQSRESVAEESTVVCPIRPWSSWTECTKPCDGGTQERVMTIKKKGKSSQHNHCKNKKEIRACNVHPC
Protein: Alpha1U protein (Q8I877)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTVLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGWRLVTIDDNKHGGLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNVQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSPSAMMSQMIGGSGKLLPFNNQANAVYEVHDWWQEQVLCPQTSDDEI
Protein: Glucagon receptor (GL-R) (P47871)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:30294546, ECO:0000269|PubMed:32677665, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding. {ECO:0000269|PubMed:9287038}.
Interaction partners:
- Pro-glucagon
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Probable non-functional immunoglobulin heavy variable 3-16
- Insulin
- Gastric inhibitory polypeptide
- VIP peptides
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
Protein: Protein krueppel (P07247)
Organism: Drosophila melanogaster (Fruit fly)
Function: Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules.
Subcellular location: Nucleus {ECO:0000269|PubMed:3112773}. Note=Chromatin associated.
Interaction partners:
- Zygotic gap protein knirps
Sequence:
MSISMLQDAQTRTLAAALAGIKQEDVHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAAAASAFGMLSPTQLLAANRQAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMYHTSGGPISPPSSGSSPNSTHDGAGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFECERCHMKFRRRHHLMNHKCGIQSPPTPALSPAMSGDYPVAISAIAIEASTNRFAAMCATYGGSNESVDMEKATPEDDGPLDLSEDGASSVDGHCSNIARRKAQDIRRVFRLPPPQIPHVPSDMPEQTEPEDLSMHSPRSIGSHEQTDDIDLYDLDDAPASYMGHQQH
Protein: Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) (Q86Y79)
Organism: Homo sapiens (Human)
Interaction partners:
- Obg-like ATPase 1
- Glutamyl-tRNA
- Large ribosomal subunit protein mL62
- Cytoplasmic tRNA 2-thiolation protein 1
Sequence:
MRPGGFLGAGQRLSRAMSRCVLEPRPPGKRWMVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWTRDRHCAADLALAPLGDAQLVLLRPRRLMNANGRSVARAAELFGLTAEEVYLVHDELDKPLGRLALKLGGSARGHNGVRSCISCLNSNAMPRLRVGIGRPAHPEAVQAHVLGCFSPAEQELLPLLLDRATDLILDHIRERSQGPSLGP
Protein: Hsp70 family ATPase (A0A1D8PRH1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- GrpE protein homolog
- Nucleoporin
- Nucleoporin NSP1
- Iron-sulfur cluster assembly protein
- DnaJ homolog 1
- Heat shock protein 60, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44
- Cysteine desulfurase, mitochondrial
- Heat shock protein SSC1, mitochondrial
- Fgr32p
Sequence:
MLRQNIARITFRRFKHHVLGIDLGTTNSAVAVMGSDQEPQIIENEEGKRTTPSIVAFSKEGETLVGLPAKRQAVVNPENTFFATKRLIGRKFEDTEVQRDLNNVPYKIIPSKQGDAMLSSHSGQTISPSEIGGLILQKLQKVAENQLKEKINSAVVTVPAYFNDSQRQATKNSGKLVGLDVLRVINEPTAAALAYGCDKSREDGIIAVFDLGGGTFDISILEIDEGVFEVRATNGNTHLGGEDFDIVIMNYILENFKAETGIDLSGDRFAVQRIKEAAEKAKIELDHSDEIEINIPFVSQDKHIKQTLTSQEFTKMVMPIIEKTIDPVKRCVRDAELKFKDIDEVLLVGGMTRMPQIRKMVQDLFGKKPSTAVNPDEAVALGAAIQGAVLSGQVKNVVLLDVTPLSLGIETYGGIFTPLIPRNSAVPIKKEQMFSTAVDGQTGVEIGVYQGERTLVKDNKHIGQFKLSNIPQGPKGTPQIAVSFEIDADGIINVSATDKTPYPKDSEHYGKPNTVAIQVTEVGLTDAEVEKMIQESNRNKKADEEKKRLYEHASRAEILCTDTETALIQFGELMEDEEKKTIKEYANTIKEMIDEIRSGEKLHHPNILNQKVNEMQKTCMEAIQKVALKQQQDKESKN
Protein: SEC14 cytosolic factor (Phosphatidylinositol/phosphatidylcholine transfer protein) (PI/PC TP) (P24280)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes in vitro. Essential for viability and secretion. Exchanges its bound phospholipid with phospholipid monomers that reside in membrane bilayers. Regulates specific trans-Golgi export pathways, like transport from endosomes to the trans-Golgi or transport from the plasma membrane to the vacuole at the level of the endosome. Increased membrane curvature and lipid unsaturation levels at the trans-Golgi membrane promotes membrane binding and phospholipid transfer of SEC14. Thus, SEC14 may act at the trans-Golgi membrane to exchange lipids and promote vesicle formation. The phosphatidylcholine-bound form of SEC14 represses the CDP-choline pathway activity by inhibiting CCTase, the rate-determining enzyme of the CDP-choline pathway. PI binding/transfer is dispensable for function in vivo. Required for trafficking and localization of lipid raft proteins to the plasma membrane.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:1997207}; Peripheral membrane protein. Cytoplasm {ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:1997207, ECO:0000269|PubMed:2466847}.
Interaction partners:
- Oxysterol-binding protein homolog 4
- Phospholipase D1
- Phosphatidylinositol transfer protein SFH5
- Choline-phosphate cytidylyltransferase
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase PIK1
- Choline kinase
- Phosphatidylinositol transfer protein CSR1
- Phosphatidylinositol transfer protein PDR17
- Phosphatidylinositol 4-kinase STT4
Sequence:
MVTQQEKEFLESYPQNCPPDALPGTPGNLDSAQEKALAELRKLLEDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAYSVMSYVREASYISQNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLPVKFGGKSEVDESKGGLYLSDIGPWRDPKYIGPEGEAPEAFSMK
Protein: KIAA0220-like protein (Nuclear pore complex interacting protein family, member A6) (Nuclear pore complex interacting protein family, member A9) (Q9NRE7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAVEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIIDNSLSLKTPSECVLYPLPPSADDNLKTPPECLLTPLPPSALPSADDNLKTPAECLLYPLPPSADDNLKTPPECLLTPLPPSAPPSADDNLKTPPECVCSLPFHPQRMIISRN
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (Q9TXV2)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MFSWLPCCSSTSNEKNAPTERRLRANDREYNAQFKYADNVIKTSKYNIITFIPQNLFEQFQRIANFYFLVLMILQFIPQISSISWYSTAVPLVIVLAFSAIKDGYDDAQRHISDRNVNGRKSYVVRNGSLCEEDWSNVKVGDVIRMMSNQFVAADLLLLSTSEPYGVCFIETMELDGETNLKNRAAIACTQEMGDDLDGITRFDGEIICEPPNNKLDKFNGKLIWNNHEYGVNNDNILLRGCILKNTRWCYGVVVFAGKDTKLMMNSGKTKFKRTSLDRFLNILIVGIVLFLIAMCLICTILCAVWEYQTGRYFTIYLPWDDVVPSPEQRGGRQIALIAFLQFFSYIILLNTVVPISLYVSVEIIRFIHSLWINYDTQMYYENGEKSVPAKAHTTTLNEELGQVQYVFSDKTGTLTRNIMTFNKCTINGISYGDIYDHKGEVIETNDKTKSLDFSWNSASEPTFKFFDKNLVDATKRQVPEIDQFWRLLALCHTVMPERDKGQLVYQAQSPDEHALTSAARNFGYVFRARTPQSITIEVMGNEETHELLAILDFNNDRKRMSVIVKGPDGKIRLYCKGADMMIMQRIHPSTSQIMRTSTNTHLADFANIGLRTLCLGYKDLDPAYFSDWDSRVKKASAAMQDRESAVDALYEEIEKDLILIGATAIEDKLQDGVPEAIARLSEANIKIWVLTGDKTETAINIAYSCRLLTDETKEIVVVDGQTDTEVEVQLKDTRNTFEQILALPSPLGGKPRIEIETIHEESEAISSARSMDRNIVTPDLKSAEMAEHESGGVALVINGDSLAFALGPRLERTFLEVACMCNAVICCRVTPLQKAQVVDLVKRNKKAVTLSIGDGANDVSMIKTAHIGVGISGQEGMQAVLASDYSIGQFKYLERLLLVHGRWSYIRMAKFLRYFFYKNFAFTLTNFWYSFFCGYSAQTVFDAVLIACYNLFFTALPVLAMGSLDQDVDDHYSLRYPKLYLPGQFNLFFNMRIFIYSVLHGMFSSLVIFFIPYGAFYNAAAASGKDLDDYSALAFTTFTALVVVVTGQIAFDTSYWTAISHFVIWGSLVLYFLVCFLLYEWLPVSWIVKTSSSISYGVAFRTMVTPHFWFSILMVSVVLLLPVMLNRFFWLDTHPSFADRLRIRKKMGKKPSAKDDKKTAFKRTAATRRSVRGSLRSGYAFSHSQGFGELILKGKLFKNVENLRGKNNSNAKIHPTSDDLQPMLISSVPDDSQGASSINAMHLPMGTRPQNVPHTLNVNTDDWSQSSDFRPAYAKEPSPLQGTVIRGDGRSHRNHVYSRETQVEEQPDVITRL