wanglab/gogpt-training-data huggingface dataset:
Protein: Autophagy-related protein 32 (Extracellular mutant protein 37) (P40458)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy-dependent peroxisome degradation.
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Vacuole membrane; Single-pass membrane protein. Preautophagosomal structure membrane; Single-pass membrane protein. Note=Is recruited to the preautophagosomal structure during mitophagy and imported into the vacuole along with mitochondria during starvation.
Interaction partners:
- Autophagy-related protein 11
- Autophagy-related protein 8
- Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
- Autophagy-related protein 19
- Autophagy-related protein 33
- Autophagy-related protein 36
- Casein kinase II subunit alpha
- Casein kinase II subunit beta
- Serine/threonine-protein kinase ATG1
- Casein kinase II subunit alpha'
Sequence:
MVLEYQQREGKGSSSKSMPPDSSSTTIHTCSEAQTGEDKGLLDPHLSVLELLSKTGHSPSPMGQNLVTSIDISGNHNVNDSISGSWQAIQPLDLGASFIPERCSSQTTNGSILSSSDTSEEEQELLQAPAADIINIIKQGQEGANVVSPSHPFKQLQKIISLPLPGKEKTPFNEQDDDGDEDEAFEEDSVTITKSLTSSTNSFVMPKLSLTQKNPVFRLLILGRTGSSFYQSIPKEYQSLFELPKYHDSATFPQYTGIVIIFQELREMVSLLNRIVQYSQGKPVIPICQPGQVIQVKNVLKSFLRNKLVKLLFPPVVVTNKRDLKKMFQRLQDLSLEYGEDVNEEDNDDEAIHTKSRSYCRNKKAENSKKKSPKSNKKPKRKKQKFFTSWFTWGISITIGISFGCCVTYFVTAAYEHQTVKSLSLRPSILASLLSLDSSSDTINTPATASPSSTEQFLWFDKGTLQINFHSDGFIMKSLTIIKETWGKMNTFVLHALSKPLKFLENLNKSSEFSIDESNRILALGYILL
Protein: Staphylococcal-like nuclease CAN2 (EC 3.1.31.-) (Calcium-dependent nuclease 2) (AtCAN2) (Ca(2+)-dependent nuclease 2) (F4IH31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond. Possesses activity toward the single-stranded DNA, double-stranded DNA and RNA. May be involved in genomic DNA degradation during programmed cell death.
Subcellular location: Cell membrane {ECO:0000305|PubMed:23102437, ECO:0000305|PubMed:24076026}; Lipid-anchor {ECO:0000305|PubMed:23102437, ECO:0000305|PubMed:24076026}.
Interaction partners:
- Endonuclease 5
- Chromatin remodeling protein SHL
- Copper ion binding protein
- UDP-glycosyltransferase 76C5
- Phosphoglycerate mutase family protein
- Leucine-rich repeat
- Insecticidal crystal toxin domain-containing protein
- Expressed protein
- Glycine-rich protein 3 short isoform
Sequence:
MGNALTFLYGKCCKPTTTDDSLGPHGVSAATVGVSALAHDLFNFEITSQVPEGLGRYVQSSRKAQANWYRKILEAWKQAKPPPQTAEEASRLVTDILKRNQKADVEGLLSFYGLPLSHTLVEVTVEAPVSLPEGILFEFQTLPVDPKAVADGDTITVYVSTSEPVVSSSVPREVNLAAVQRAKAREKRNYPKADELHQKIIDSGYRVLNIENEEVLARKFRIRLRGIDAPESQMPFGKEAQEGLLKIVGRKSLKVLVYGEDQYGRCVGDLYCNGIFVQEAMLKKGLAWHYLAYDKRPVLAKWEKEARQKRIGLWASSNPEKPWDWRKNNRRE
Protein: At3g14170 (Q6NKR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASLTPRVLIKLLETMNTNIKVRGEYRSVLLQVISIVPALAGSELWPNQGFFIKVSDSSHSTYVSLSNEDNELILNNKLGIGQFFYVDKLDAGTPVPVLVGVRPISGRHPFVGNPKDLMQMLVPSETTPREEEYHNQKKKDGARSNIVENIRKHQPFVIKEEKTGVASRYMKGISNSKASGSDSSSGGSNNEGETGSIMVAKKVGVLAKGKQREHKDQARQAGPLQCRPATAPTKAEPKKLSLSSTVNYINRKSNSAEDASWSSLPVSLSKLGKGMLRRRNLAALIAAEVQREALAASHLIKCISMFAELSSNASPKNPHTSLRNFFTLQSILDQVQVTVVASKDKSFQPVNIHSLWMEPEKLSKKASLSSSRATMKPSKALTEAEKLEWVKGNGTEEIKELTNTLKRETRSWFLKFLEDALDTGLHATVPEKKGKTKGARLAEPDNHIAETLSQLKQANEWLEKVKNDNLSSDNSLLENIERLKKKIYSCLLLYVDSAASAIGV
Protein: Tip elongation protein 1 (Protein noc1) (P79065)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11007487, ECO:0000269|PubMed:15177031}. Note=Located at the microtubule tips.
Interaction partners:
- Microtubule integrity protein mal3
- Kinesin-like protein tea2
- Tip elongation aberrant protein 1
- Spindle pole body component alp14
- Actin-interacting protein 3 homolog
- Tip elongation aberrant protein Tea4
- Myosin-52
- Kinesin-like protein 5
- Anaphase spindle elongation protein 1
- Protein peg1
Sequence:
MFPLGSVVEVITGERGFVRYAGEVENRKGVYVGLELLPEFAEFGKNRGVVDGREYFKTKNNEKTGIFVPFDKCKLASSISSSPSPKIDGTAASIGMGFPPMSPNLQSSIPRLTNVSSSSNLSMNTISSTALTPTEKILQKRIEDLLYERQNHQQQLEEVLATVDQLQSLVTNFNDQQDEVDELRERITLKEERIQQMRNEASQRRFEFKTTIECLEESSNRAIETYENRIAELEAQLEMYMSGKSEDDLLFSLQQERDYALNQVEILQERVDTLMKQKANSSTANEKLSHMESSSPTLTNASFESPKRGKGSNDLPENHPQRRQTLEFYEIEIEVLREKVEKLQALSDEKDFYISKLEKSLDRNDTTPVPSDEKLSNYAAEKENLVSRISELEHTIEQLTINNERDNERMSPAEFELETTQEVEENDSDSHDDEETWCEVCETNNHSLQECPTVFGSTDEA
Protein: Transcription factor BEE 1 (Basic helix-loop-helix protein 44) (AtbHLH44) (bHLH 44) (Protein Brassinosteroid enhanced expression 1) (Transcription factor EN 77) (bHLH transcription factor bHLH044) (Q8GZ13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Positive regulator of brassinosteroid signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor IBH1
- Transcription factor BIM1
- Transcription factor PAR1
- Protein BRASSINAZOLE-RESISTANT 2
- Homeobox-leucine zipper protein HAT2
- Transcription factor PRE1
- Transcription factor HFR1
- Transcription factor BIM3
- Protein BRASSINAZOLE-RESISTANT 1
- Protein EXORDIUM
Sequence:
MANFENLSSDFQTIAMDIYSSITQAADLNNNNSNLHFQTFHPSSTSLESLFLHHHQQQLLHFPGNSPDSSNNFSSTSSFLHSDHNIVDETKKRKALLPTLSSSETSGVSDNTNVIATETGSLRRGKRLKKKKEEEDEKEREVVHVRARRGQATDSHSLAERVRRGKINERLRCLQDMVPGCYKAMGMATMLDEIINYVQSLQNQVEFLSMKLTAASSFYDFNSETDAVDSMQRAKARETVEMGRQTRDGSPVFHLSTWSL
Protein: CDKN2A-interacting protein (Zgc:101658) (Q5XJR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MAARRGEDIVSEFLSQNPHLVSWVESLRGHCETNKQWYARREFVLRNMEAFPTIQPGSPSSSLDRLLSLSMVWANHVFLGCRYPQRVMDKINEMAEGITVIEAPERKTRDEIMGKLKRPAVSAADADYQGKKNKPNEPDDRAHSKCVVHPATSSHKCGPSPGAPAEHQPFFNRLYKAVAWKLVSAGGFGPNLEHFEILRSCVESCKASLTCVFVPLKDIPDLPAGRTQREGQVCELRCCTVYMGTGYGRDESAARAMASKEALKVFQGQKVTVKISRRRFRGRDVDDLVLLDEQSRSQAFPPALSCPFQEDE
Protein: Netrin-G1 (Laminet-1) (Q9Y2I2)
Organism: Homo sapiens (Human)
Function: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21946559}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21946559}; Extracellular side {ECO:0000269|PubMed:21946559}.
Interaction partners:
- Leucine-rich repeat-containing protein 4C
- Leucine-rich repeat-containing protein 4
- Leucine-rich repeat-containing protein 4B
- Cyclin-dependent kinase-like 5
Sequence:
MYLSRFLSIHALWVTVSSVMQPYPLVWGHYDLCKTQIYTEEGKVWDYMACQPESTDMTKYLKVKLDPPDITCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPGNSWHYGCQPNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEKLRCEEAGSCGSDSGQGAPPHGSPALLLLTTLLGTASPLVF
Protein: L-cystine transport system permease protein TcyL (P0AFT2)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex TcyJLN involved in L-cystine import. This high affinity cystine transporter is involved in resistance to oxidative stress by forming a L-cysteine/L-cystine shuttle system with the EamA transporter, which exports L-cysteine as reducing equivalents to the periplasm to prevent the cells from oxidative stress. Exported L-cysteine can reduce the periplasmic hydrogen peroxide to water, and then generated L-cystine is imported back into the cytoplasm via the TcyJLN complex. Functions at low cystine concentrations. The system can also transport L-cysteine, diaminopimelic acid (DAP), djenkolate, lanthionine, D-cystine, homocystine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Responsible for the translocation of the substrate across the membrane (Probable).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- L-cystine transport system ATP-binding protein TcyN
- L-cystine-binding protein TcyJ
- Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ
- Glutamine transport ATP-binding protein GlnQ
- Glutamate/aspartate import ATP-binding protein GltL
- Putative ABC transporter arginine-binding protein 2
- Lysine/arginine/ornithine-binding periplasmic protein
- Glutamine-binding periplasmic protein
- ABC transporter arginine-binding protein 1
- Histidine-binding periplasmic protein
Sequence:
MQESIQLVIDSLPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYISIFRGTPLIAQLFMIYYGLPQFGIELDPIPSAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTPWQTMRRAILPQAARVALPPLSNSFISLVKDTSLAATIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSTLQNHFENQLNRQEREPK
Protein: Structural maintenance of chromosomes protein 6 homolog smc-6 (G5EG17)
Organism: Caenorhabditis elegans
Function: Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister-chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication.
Subcellular location: Nucleus {ECO:0000269|PubMed:20661436}. Chromosome {ECO:0000269|PubMed:20661436}. Note=Nucleoplasmic in the distal gonad arm and localizes on chromosomes during pachytene, diplotene and diakinesis in oocytes. {ECO:0000269|PubMed:20661436}.
Interaction partners:
- Structural maintenance of chromosomes protein 5
- Phorbol-ester/DAG-type domain-containing protein
- E3 SUMO-protein ligase NSE2
- Structural maintenance of chromosomes protein 3
- Non-structural maintenance of chromosomes element 4
- PAX-interacting protein 1
- RecQ-like DNA helicase blm-1
- Crossover junction endonuclease MUS81
- Cohesin subunit scc-3
- DNA topoisomerase 3
Sequence:
MGKRDIPSPNENIAPRTIGMRDVDLTAAPAKKAKLDTGERIAVSGRVASVKLTNFMCHANLQIDFKTAQNNCFYIGGPNGSGKSALFAAINLGLGGRGSDNDRGNTVKSYIKDGTTQSKITITLTNAGLNAHPDFDDLISIERTINQASSTYIMKSVKVTSSDNHVERIVSRKKADVDRIVSRFSIHLSNPAFWMSQDRSRSFLANFKPANVYKLYLESTNLENIRLSYIRFADALDECFALIQLKAGEILNEQKKLKRMQEQRDLQAKLDQDRALVASFCWKLLFCKVRDYNDQIELTLKKQEAQKTLQDETKKEYAKNRAARTEVEKKIQEFRDEVEVQDAEIAEAREDLDAKKRKVLEFEEKIRECEQSIRKKTSEKKYMERTIVNAKNEVRILLEKQGNQDLTKRLTKVENDYKDISQQRENMELGGESAKLREKLDTVITDYKRKEEEKYTIQRDINQLRRKIEQDMETMRRSRATKKDAINKFGSHMAEILMEINRSKSRFQTVPKGPLGKYITLIDPKWAFTVEECIGNLANNFLCSSHLDAEILRNIFQSLRIPAQDRPTIIVAKCNGRAYTNLHEPSSDFKSIYRVLKFSDPDVHNVIIDKSNCEQFILIEDKTEAMELMGSNYPPQNAVKAYTLDGSQAYANGPNSQYRFYSGRGGHARGTFGNDQGDVDEGALARLIEDTKSEAMRLETQDLRKQDHELKVIYNERDQTKAAIDEFDRKLSNLRSQELQKERQAKDLRAELAQTANEDQVENLNESIEEMQKKIPLIEDEVKDILKNVADITADMAPVIQERKEAEHTLAEIQKETRDFASKSQKLQNELSKYDDAGEILKIRLDKVKADEGVFFHTEAKLKSERDDAMEMVENDKKNHPMPPGETDPPDLSSFPSTTEAQRKIEEMQKAVDRATVGCDTTITLECVKDFKDKLKRLKYLCRMIEDVLIELKNLHAARVKAYPSLKKFTELKVCNKFQELLAVRGHFIGGLEFDHEKETLNVNVQSSKEKDAMAGRRPEVLEVEEVDEHSYDDDSDDSTGPRRKKSKKSGQKKKRVRDLKGLSGGERSFVTAALVMSLWEVMEQPFRMMDEFDVFMDMMNRKLVMDLLVELATKKFPHNQFIFFTPQGIKELNMVDGLQVFEMNRVRD
Protein: Probable transposase (P96366)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable IS1560 transposase
- Probable transposase
Sequence:
MPHPTTLMKLTTRCGSAAIDGLNEALLAKAAEAKLLGTNRIRADTTVARANVSYPTDLGLLAKAMRRIAATGKRIQAAGGAVRTRVGDRSRAAGRRAHAVAAKLRSRAELGRDEARAAVLRFTGELAELAQAAAQEAQQLLDNAKQAVLRAKAKAAALAARGERDAVAGRRCGGLVRAVNDLTELLNATRQIVAQTRQRVAGITSDGASRRVSLHDGDARPDHQGSAR
Protein: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-acetylglucosaminyltransferase I) (GlcNAcT-I) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (Protein COMPLEX GLYCAN LESS 1) (Q9XGM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Required for normal root growth and morphology.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18768906, ECO:0000269|PubMed:8127889}; Single-pass type II membrane protein {ECO:0000269|PubMed:18768906, ECO:0000269|PubMed:8127889}.
Interaction partners:
- Alpha-mannosidase 2
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS2
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Glycoprotein 3-alpha-L-fucosyltransferase A
- Alpha-
- Putative fucosyltransferase-like protein
- Beta-1,2-xylosyltransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dol-P-Man:Man
Sequence:
MARISCDLRFLLIPAAFMFIYIQMRLFQTQSQYADRLSSAIESENHCTSQMRGLIDEVSIKQSRIVALEDMKNRQDEELVQLKDLIQTFEKKGIAKLTQGGQMPVAAVVVMACSRADYLERTVKSVLTYQTPVASKYPLFISQDGSDQAVKSKSLSYNQLTYMQHLDFEPVVTERPGELTAYYKIARHYKWALDQLFYKHKFSRVIILEDDMEIAPDFFDYFEAAASLMDRDKTIMAASSWNDNGQKQFVHDPYALYRSDFFPGLGWMLKRSTWDELSPKWPKAYWDDWLRLKENHKGRQFIRPEVCRTYNFGEHGSSLGQFFSQYLEPIKLNDVTVDWKAKDLGYLTEGNYTKYFSGLVRQARPIQGSDLVLKAQNIKDDVRIRYKDQVEFERIAGEFGIFEEWKDGVPRTAYKGVVVFRIQTTRRVFLVGPDSVMQLGIRNS
Protein: RE50319p (Q5U199)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQELDISIPSTDFASQLLLLFFYNKMQSQRFLFVAILACFLVTIKSTPLSDISYSDESTSVNEKTQKRPDDDSEFDGFPFREDDDSLQDSSREMSVQDHNWDVLIFTQQWPVTTCYHWREENPDQECSLPQKKEFWTIHGIWPTKLHQMGPNFCNNSANFDPSKLNPIEDRLETFWPDLKGMDSTEWLWKHEWQKHGTCAMLVEELDNELKYFEQGLTWREEYIMSRILDASDIHPDSNNTVAAINNAIVKALGKNPSIHCLYDGKHGISYLSEIRICFSKSLELIDCDGIKQGDAVPVGVPGGTIITNCHIGSLVHYPSLVPPLQRKSHWKLPLVNVYKLLQFLMWFTL
Protein: Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Delayed early response protein 2) (DER2) (Q02013)
Organism: Mus musculus (Mouse)
Function: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12133842}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29972}.
Interaction partners:
- Aquaporin-11
- Aquaporin-12
- Band 3 anion transport protein
- Aquaporin-9
- Ammonium transporter Rh type A
- Aquaporin-5
- Aquaporin-3
- Aquaporin-7
- Aquaporin-2
Sequence:
MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
Protein: [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) (Q2MJQ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein unc-45 homolog B
- Actinin alpha 3b
- Protein-lysine N-trimethyltransferase SMYD5
Sequence:
MEFVEVFDSPGKGRGLRATKEAWAGDVLFAEPPFASVVFDSQASSICHSCFRRQEKLQRCGQCRFAQYCDKTCQRAGWEEHKLECAAIKTYGKPPSENVRLAARILWRMDKQGSVVSDNQLTTLEDLEDHICDISEDDLKDFKVDIHNFLDYWPRNSKPHTVDSVSHILGVINCNGFMVSDQRGLQAVGVGLFPNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIELRALGKISAGEEVTVAYVDYLNVSADRQRLLKQQYFFDCTCKHCTEKIKDDLKMAGAEVDGVKVPEEQVKEVTEFSRQKLEKMEKARIEANYNEVVKICRECVEKQENVLADTHIYYLRVCCTLSEVLSYLQFFDEASEYARKMVDGYLKLYHPNNAQLGMATMRAGVTHWQAGFIEVAHGMICKAFAILMITHGPTHPITKDLEAMRMQTEMELRMFQQNEYVYHSMREAALKNQPMRMMAEPTNEGIKNLFRRK
Protein: Multiplexin, isoform O (E1JIE3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRVLQGVMFALAMICTLLVPVLGSFELVGQSIKDALAEYTLTDIMNNNQFAGIEFGEAEDGFPAFRFLQTADVKSPYRMLLPEKLYEFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNSYNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIELVFDSASTLYIGQAGSIIGGKFEGYLEKINVYGNPDAINVTCMPPPKATIAPTTADDGSIFYEGSGENILFEDSTEANILSDDFWNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAKGVPGEKGDAGQKGERGDPGHKGAHGPSGAKGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGRPGMTGPKGEMGPKGPKGDSGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPKGEPGVDSRSSFFGDASYYGRPEPPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTWYPRMLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVEALSQDRKRKKREIGDGSSHGESESREFKTADEYAAHLENLLL
Protein: DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) (O75575)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:33335104}. Cell membrane {ECO:0000250|UniProtKB:O35427}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35427}; Cytoplasmic side {ECO:0000250|UniProtKB:O35427}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
Sequence:
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA
Protein: EH domain-binding protein 1 (Q69ZW3)
Organism: Mus musculus (Mouse)
Function: May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8NDI1}. Membrane {ECO:0000250|UniProtKB:Q8NDI1}. Endosome {ECO:0000250|UniProtKB:Q8NDI1}. Note=Mostly found in cytosol and plasma membrane. {ECO:0000250|UniProtKB:Q8NDI1}.
Interaction partners:
- EH domain-containing protein 2
- EH domain-containing protein 3
- Ras-related protein Rab-8A
- Ras-related protein Rab-10
- EH domain-containing protein 1
- Rabenosyn-5
- Protein kinase C and casein kinase substrate in neurons protein 1
Sequence:
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSATLQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANVPSAKSASSSEELINTLNFLDEAQKDLATVNTNPFDEPDVTELNPFGDPDSEEPITETTSPKKPEESFYNNSCNPFKGVQTPQYLNPFDEPETFVMIKDSPPQSTRRKNLRPVDMSKYLYADSSKSEEELDESNPFYEPKPTSPNNLVNTVQEGETERRVKRRAPAPPAPLAPPAPPAPPALTPKTGVNENTVVSAGKDLSTSPKPSPIPSPVLGQKPNASQSLLAWCREVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPEPHQPARGAVDLLSQDDSVFVTDSGVGESESEHQTPDDHLSPSTASPYYRRTKSDTEPQKSQQSSARTSGSDDPGLSSSTDSAQALASLGKKRLKAENLELSDLCVSDKKKDVSPLSAYEQKLQTVHASSDMEQGKMEKSRSLECRLDGELAITKPNVSSPSKLGYNRDTDFTKKPCASLRQIESDPDADKSTLNHADHPNKAVQHRMLSRQEELKERARVLLEQARRDAAFKVGSKHGGSAAPALCSRQLNDQQDEERRRQLRERARQLIAEARCGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNIESDLDNPEQNSKVVDLRLKKLLEAQPQVANLLPSAAQKAVTEASEQGEKSGVEDLRTERLQKATERFRNPVVFNKDSTVRKTQLQSFSQYVENRPEMKRQRSIQEDTKRGTEEKAEITETQRKPSEDEKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVDKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCALQ
Protein: Imidazole glycerol phosphate synthase subunit HisH 2 (EC 4.3.2.10) (IGP synthase glutaminase subunit 2) (EC 3.5.1.2) (IGP synthase subunit HisH 2) (ImGP synthase subunit HisH 2) (IGPS subunit HisH 2) (P72138)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Imidazole glycerol phosphate synthase subunit hisF1
- Putative imidazole glycerol phosphate synthase subunit hisF2
- Imidazoleglycerol-phosphate dehydratase
- 1-
- Histidinol dehydrogenase
- ATP phosphoribosyltransferase
- O-antigen polymerase
- LPS biosynthesis protein WbpG
- Phosphoribosyl-AMP cyclohydrolase
- UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
Sequence:
MIVVIDYGVGNIASVLNMLKRVGAKAKASDSREDIEQAEKLILPGVGAFDAGMQTLRKSGLVDVLTEQVMIKRKPVMGVCLGSQMLGLRSEEGAEPGLGWIDMDSVRFERRDDRKVPHMGWNQVSPQLEHPILSGINEQSRFYFVHSYYMVPKDPDDILLSCNYGQKFTAAVARDNVFGFQFHPEKSHKFGMQLFKNFVELV
Protein: IP12350p (Stac-like, isoform A) (Q1EC92)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGISAHAAPASFWNHPRRIRRTPTSDRDGVDQCRPWICRRKDRRPAHPAANRPPESRVCGPSSTFRWDDWAAPAPRTRERATDCARMCMCTSRIPYSVARICARTTSMHSSRPASRSSSFIRRPLTRRQRMAVGGVTRRLWRTMRVYTIHQGRGVRRARAAQAVAAYLRDRRARIGKGWPAQGHGVRISATEQWADKPVVRRPGDPTRRVAAGAVPVLAERLPKVTGSSVKSSSGRRSRRRRIFGWRGPRGGSLSPQGGSMASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSDFSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIEGQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPSMKTKWLKAFKSLKPAGSGSAQQADRRNGASSTASEPLRPNLDGSHHLQEYTYKKITACDVCSQILRGHTRQGLRCRICKLNAHGDCAPNLPRCQPKQKLLRRQKSTSELENRVDIEEETSANPKSETTRPFGEPLMLLKSTESNPDESKGNRRVR