wanglab/gogpt-training-data huggingface dataset:
Protein: Plexin A3 (B0S5N4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Neuropilin-1a
- Semaphorin-3ab
- Sema domain, seven thrombospondin repeats
- Sema domain, immunoglobulin domain
- Semaphorin-3D
- Sema domain, transmembrane domain
- Neuropilin
- Semaphorin 7A
- Semaphorin-5A
- Semaphorin-2A
Sequence:
MRSLWLLVFSFSVLTGTNMAFPMILSERPEVTGSFKVKDTSLTHLTVHRKTGEVFVGAINRVYKLSANLTETRSHQTGPVEDNAKCYPPPSVRACTQKLESTDNVNKLLLVDYAGNRLVACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAKESDGMAGVVVGDDDGDLKKKKKGGSRLFIGAAIDGKSEYFPTLSSRKLVADEESVNMFSLVYQDEFVSSQIKIPSDTLSQYPAFDIYYVYGFSSRTYIYFLTLQLDTQLTQVDVTGEKFFTSKIVRMCSNDTEFYSYVEFPLGCTKDGVEYRLVQAAYKHRPGKILAQALGLSEDEDVLFVIFSQGQKNRANPPRETVLCLFTLHQINLAMRERIKSCYRGEGKLSLPWLLNKELPCINTPKQIGDDFCGLVLNQPLGGLMVIEGIPLFDDRTDGMASVAAYTYGDHSVVFVGTRSGHLKKIRVNGVPPPSENALLYETVTVVEGSPILRDMVFSPDYQYIYLLSDKQVSRLPVESCSQYSSCKTCLGSGDPHCGWCVLHNKCSRKEACEKWAEPLHFSTELKQCVDITVTPDNMSVTSVSTQLSVKVANVPNLSAGVTCVFEELTESPGEVLAEGQILCMSPSLRDVPSVTQGYGDKRVVKLSLKSKETGLKFITTDFVFYNCSVLQSCSSCVSSPFPCNWCKYRHICTNNVAECSFQEGRVSSAEGCPQILPSSDILVPAGIVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNSSCIQCQNTSYWYEGNEMGDLPVDFSIVWDGDFPIDKPSSMRALLYKCEAQRDSCGLCLKADSTFECGWCLADKKCLLKQHCPSAEHNWMHQGRRNIRCSHPRITKIRPLTGPKEGGTRVTIEGENLGLQVREITHVRVAGVRCNPAAAEYISAERIVCDMEESLMSSPPGGPVELCIGDCSAEYRTQSTQTYSFVMPSFSRVRPEKGPVSGGTRLTISGRHLDAGSAVTVFLAQEECLFVRRTVREIVCVTPPSASGSGPSSVKLFIDKAEITSDTRYIYTEDPNISTIEPNWSIINGSTSLTVTGTNLLTIQEPKVRAKYGGVETTNICSLVNDSVMTCLAPGIIYTKREAPESGVHPDEFGFILDHVSALLILNGTPFTYYPNPTFEPLGNAGILEVKPGSPIILKGKNLIPPAPGNIRLNYSVTIGETPCLLTVSESQLLCDSPDLTGEQRVMILVGGLEYSPGMLHIYSDSTLTLPAIIGIGAGGGVLLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIQELTNDMDGVKIPFLEYRTYTMRVMFPGIEEHPVLKELDSPANVEKALRLFSQLLHNKMFLLTFIHTLEAQRSFSMRDRGNVASLLMAALQGRMEYATVVLKQLLADLIEKNLENRNHPKLLLRRTESVAEKMLTNWFTFLLHRFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKQLTLMCIPPEGEAGTEIPVKVLNCDTITQVKDKLLDAVYKGIPYSQRPQADDMDLEWRQGRLTRIILQDEDVTTKIESDWKRLNTLAHYQVTDGSLVALVQKQVSAYNIANSFTFTRSLSRYESLLRTSSSPDSLRSRAPMITPDQETGTKLWHLVKNHEHADQREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADKRQITDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDISKMPSISDQDMDAYLVEQSRLHGNEFNTLSALSELYFYINKYKEEILTALDRDGYCRKHKLRHKLEQAINLMSGSS
Protein: Esculentin-1SEa (P85059)
Organism: Lithobates sevosus (Dusky gopher frog) (Rana sevosa)
Function: Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against the Gram-negative bacterium E.coli K12 and Gram-positive bacterium M.luteus NCT C2665.
Subcellular location: Secreted {ECO:0000269|PubMed:16386333}.
Interaction partners:
Sequence:
GLFSKFNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC
Protein: Phosphatidylinositol-3-phosphatase SAC1 (AtSAC1) (EC 3.1.3.64) (Factor-induced gene 4-like protein) (AtFIG4) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase SAC1) (Phosphatidylinositol-4-phosphate phosphatase) (Protein FRAGILE FIBER 7) (Protein SUPPRESSOR OF ACTIN 1) (SAC domain protein 1) (Q7XZU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Required for normal cell morphogenesis, cell wall synthesis, and actin organization.
Subcellular location: Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:15805481}.
Interaction partners:
- 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A
- 1-phosphatidylinositol-3-phosphate 5-kinase FAB1B
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Protein VAC14 homolog
- Phosphatidylinositol 3-kinase VPS34
- Phosphatidylinositol-3-phosphatase myotubularin-2
- Phosphatidylinositol-3-phosphatase myotubularin-1
- Phosphoinositide phosphatase SAC5
- Phosphoinositide phosphatase SAC4
Sequence:
MAKSENSTTSTFSSFANKIQPSNDAESDPDSYALEKFKLYETRARFYLVGSDRNKRFFRVLKIDRSEPSELNISEDPVVYSPQEIKSLLQRIAEGNRATGGLAFVAKVYGIAGCAKFMESYYLVLVTKRRQIGCICGHAIYAIDESQMISVPHATIQSDVANSKTELRYKKLLSSVDLTKDFFYSYTYPIMQSLQKNVLSSGEEGMPYDNIFVWNSYLTQPIRSRCNNTIWTLALVHGHFKQIRLSIYGRDFSVTLVSRRSRHFAGTRYLKRGVNDRGRVANDVETEQLVLDDEAGSCKGKMSSVVQMRGSIPLFWSQEASRFSPKPDIFLQRYDPTYESTKMHFEDLVNRYGNPIIVLNLIKTVEKRPREMVLRREFANAVGYLNSIFREENHLKFIHWDFHKFAKSKSANVLAVLGAVASEALDLTGLYFSGKPKIVKKKASQLSHANTAREPSLRDLRAYSAELSRGESANDILSALANREKEMKLTQQKKDEGTNSSAPRYQSGVLRTNCIDCLDRTNVAQYAYGLAALGRQLHAMGLSDTPKIDPDSSIAAALMDMYQSMGDALAQQYGGSAAHNTVFPERQGKWKATTQSREFLKSIKRYYSNTYTDGEKQDAINLFLGYFQPQEGKPALWELDSDYYLHVSGIGDDIFPDIGVQSIAKPMSGIGVNLAPVPAFRDDFSRKKLTSFDKLIEQTCSSIKNVRLCSETDQRPGGNTGSTGVAPDAAEIQLKSPNWLFGSRKPEESSSATKSGADDSEKGVTSTERVNDFCNLDWLSKSDRHQGDIFQRYLSITSTNEANGWYGGTLLGDQDENSEIYRHYAQFCQCPAMEPFENDHEFEQNFAEVLRMNTIDVMDIEEEETEMESDFNEYTQIGSDLGIIPMQCKHFASDPCWLARWLVGDDKVPKVI
Protein: Probable thymidylate synthase (EC 2.1.1.45) (Q6QGJ5)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Sythesizes the thymine necessary for the viral DNA replication.
Interaction partners:
Sequence:
MQQYLKILTDVILLGEPRNDRTGTGTVSIFDSYAKFDLREGFPAVTTKRLAWKSVVGELLWFLSGSTNLHDLRVFTFGRDEGQWTIWTPNYEDQAISMGYDKGNLGPVYGKQWRNFGGRDQILELIEGLKNNPHGRRHLVSAWNVAELDKMALPPCHYGFQCYVSNDGYLDLKWTQRSVDCFLGLPFNIASYALLTHILAKLTGLKPRYLIFSGGDTHIYNDHMEQVEEQVKRKPRPLPTLVMPEFVDLYDLLENNTAAWSFHLEGYDPHPALKAKMSS
Protein: Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor TGR-1) (G-protein-coupled receptor FM-4) (Q9ESQ4)
Organism: Rattus norvegicus (Rat)
Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Neuromedin-U
- Neuromedin-S
- Neuromedin-U receptor 1
Sequence:
MGKLENASWIHDPLMKYLNSTEEYLAHLCGPKRSDLSLPVSVAYALIFLVGVMGNLLVCMVIVRHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEIYEMWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQHFPNGSSVPGSATCTVTKPMWVYNLIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEANKVAVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVEEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPTCKWCHPRHRPQGPPAQKIIFLTECHLVELTEDAGPQFPGQSSIHNTNLTTAPCAGEVP
Protein: Methyltransferase type 11 domain-containing protein (Q38AK8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Multifunctional methyltransferase subunit TRM112
Sequence:
MSAPTERERLGNDKVTEVQPTELLDVAGIERRHVQQVYDDIATHFSATRYKAWPRVRAFIESLPRYAAVVDVGCGNGKYFSCAQNFMAATSNAPDDGANEEGQTGPAYRFVAGVDFSERLLRLALNQLDHEASETSPSSSRSLGTRGRTELLLADARRTAFRNGAFDAAISIAVVHHFATHERRLDAVRELLRLVRPDGLILIYVWAKERPEKRPRSGASDVFIRWEMHEAHDPERRVHHRYYHLFGEGELERLVEEAGGVVRESYFDKENWCVVLQKSKRGEQ
Protein: CRISPR-associated protein Csy3 (Q02MM1)
Organism: Pseudomonas aeruginosa (strain UCBPP-PA14)
Function: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.
Interaction partners:
Sequence:
MSKPILSTASVLAFERKLDPSDALMSAGAWAQRDASQEWPAVTVREKSVRGTISNRLKTKDRDPAKLDASIQSPNLQTVDVANLPSDADTLKVRFTLRVLGGAGTPSACNDAAYRDKLLQTVATYVNDQGFAELARRYAHNLANARFLWRNRVGAEAVEVRINHIRQGEVARAWRFDALAIGLRDFKADAELDALAELIASGLSGSGHVLLEVVAFARIGDGQEVFPSQELILDKGDKKGQKSKTLYSVRDAAAIHSQKIGNALRTIDTWYPDEDGLGPIAVEPYGSVTSQGKAYRQPKQKLDFYTLLDNWVLRDEAPAVEQQHYVIANLIRGGVFGEAEEK
Protein: Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (GTPase EF-hand protein of mitochondria 1) (O59781)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P39722}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P39722}.
Interaction partners:
- Mitochondrial distribution and morphology protein 12
- Mitochondrial distribution and morphology protein 10
- Mitochondrial distribution and morphology protein 34
- Maintenance of mitochondrial morphology protein 1
- Mitochondrial import receptor subunit tom7
- Probable mitochondrial import receptor subunit tom40
- Mitochondrial import receptor subunit tom22
- Mitochondrial import receptor subunit tom20
- Probable mitochondrial import receptor subunit tom70
- Uncharacterized protein C16H5.12c
Sequence:
MKEVRVVICGDQGVGKSSLISALIQEDNVTSIPKVFPIISIPSNPDSNDDVSLVLVDTQSDSNEREYLAAEIKKANVICLVYSDNYSYERVSIFWLPYFRSLGVNVPIVLCENKSEDLDNYQGLHTIEHEMIPLINEFKEIEACILCSALEKINVNELFYMCRACVIYPITPLWDAKERTMRKATIHALSRIFFLIDKNNDDLLSVDELNSLSEKCFSKNLSIEDASEILSKVKEICPEGVYEGQLTLPGFLAYNRVQVENGKQESTWGILRAFHYTDSLSLDDSYLSPKFEVAPGQIVELSPKGYRFLVDLFYQFDRDNDGALNNEELSALFRHTPGLPEIWVSSQFPNSTVLNEHGYVTYNGWLAQWSMITLFDYKTTLAYLAYLGFDTDGRGHNTDALKVMRKRVSQNRKVSKYDRNVFLCFVVGSKSCGKTALLSSFINNNTNRLTPNTVVNSVEFQSTQRYLVLSEIGETDLDILAEPKSLEACDILCLLYDSSNPNSFSFIANLLNLYPDLQKIPCVFAATKADLDRQQQRYPVQPDEFTKQLGLPSPTHISTAAIWNTSKEFFIQLAESAQYPASSIIRIPEEDSNKTNYQLVAALTAFGALLLSVGGSLTWKIIKHQYYSKK
Protein: Alpha-toxin OD1 (P84646)
Organism: Odontobuthus doriae (Yellow Iranian scorpion)
Function: Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels. The toxin affect mammalian sodium channels Nav1.7/SCN9A (EC(50)=4.5 nM), Nav1.4/SCN4A (EC(50)=9.6 nM), Nav1.6/SCN8A (EC(50)=30 nM), Nav1.5/SCN5A (only at micromolar concentrations), and insect sodium channel para/tipE (EC(50)=80 nM). In vivo, intraplantar administration of this toxin elicits pain behaviors, including licking and flinching of the hind paw.
Subcellular location: Secreted {ECO:0000269|PubMed:16038905}.
Interaction partners:
Sequence:
GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRIPGKCR
Protein: Polyadenylate-binding protein-interacting protein 4 (PABP-interacting protein 4) (Poly(A)-binding protein-interacting protein 4) (PAM2-containing protein CID4) (Protein CTC-INTERACTING DOMAIN 4) (Q94AM9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g24050/T23E23_11
- RNA-processing, Lsm domain-containing protein
- Polyadenylate-binding protein-interacting protein 6
- Polyadenylate-binding protein-interacting protein 5
- Polyadenylate-binding protein-interacting protein 11
- Polyadenylate-binding protein-interacting protein 13
- Polyadenylate-binding protein-interacting protein 2
- Small nuclear ribonucleoprotein-associated protein
- Small nuclear ribonucleoprotein-associated protein
- Polyadenylate-binding protein-interacting protein 10
Sequence:
MSIPQSKSSSNGFPLKRGETEEVLHKTNTSNTVFNGEAGSLKRLSLDRLVYFTTCKIGHHVEVHLRNGSVYTGIFHAANVEKDFGIILKMACLIKDGTLRGHKSRSEFVRKPPSKTFIIPADELVQVIAKDLSVSSNNMSNAVQGEKPSELLTDSSISQSYHVDRERQLQRWVPDETIPHGADLENVFDNPWNRKWNQFEVNKSLFGVKSTFDEDLYTTRLERGPQTKQLEEHAQKIAREIEAETTRDIHVAEERGLQLNENFDFDEEARYSSVRPVTGFGDSGFDLEDNALLDTCNDLTFGGSSTSDGQKPASSGKGCEELRVSGDSQSSRKNKNVDQSCSTSKQQSKDFPAAGSNISESQLDEQRRKNNEEVSHNNRSAEESTSGHGDIKEGAKSGGGASSVSKAVTEREREASQVSSKTKSESSFGQSASRSSESRPGPSTSSRPGLSPSSSIGSMASSEKSTLNPNAKEFKLNPKAKSFKPLQSAAAPPQSPIADASFYYPGPSHVPVQQMPGMPPVNYGLPPYPGNQPQMMYHPQAYYHPNGQPQYPQQQMIPGQQQQQMIPGQQHPRPVYYMHPPPYPQDMPYHNKGRE
Protein: RING/U-box superfamily protein (F4IS08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDSAPSPSSLDFELSPPVLVTMTSTSSSASDNVEGADDDANTHGIFNWRDFSSCWRVSESNLYCFSLALLIWFFASFILIENLYGPKNVWLGPSSSILVEPSSIFVKSIKVKVLDYSEPGLQLYGFYRTPALDCFVNWSESRVLSISHESYKGWPYYLNSGSLLNITYTVKPQGSAVQLVVDEGHQGVPQSVLNDPAYRYNVWSWNLIEGSGMIQLEIRKSSSYYLAVANLKSKDVEVTTTDQVELNIDVKAVLYDTKQSFYNCNFSNGECTFNAMSLVGNSVVVTSPAASQGVSIEDEWYIRFSYQPREIAYVIGTGVVICFMLVAIQFCNRFQCSGGEGHLTEDDSARTRLLADKDDDGSSMGSCDDSYANDDADLEEFMGNDGEASNRSRRLCAICFDVPRDCFFLPCGHSVSCYECGTTMQEADGSCPICRRKMKKVKRIYTV
Protein: Probable nucleolar pre-ribosomal-associated protein 2 (Ribosome biogenesis protein urb2) (Q09804)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C14G10.02
- ATP-dependent RNA helicase dbp6
Sequence:
MSLQTLTKRIRDKNGSREDQIDLANKLFRGEVDVYFPNKEEFIINFLLDRLKENSNLTCVNIGYWQLFLNIWKSDKLSGSFRVSAIRRQSLYPIILNAFEYLIKEFKKDVFLKISDVFVCVYSNLNILYISRSFPDQISLLFSRYCYLIASKIDDLLDSHPNEVFKETLICVIQSAVHSQASSTKAQTQFLHQTLGSILALLCKTQKGDPYFSFLNAVLMKCVLTQHTLDVLLLTKKDSSMTLCSLLNAISFEPINLKAIPLFFIICADSINFHLSSVEKSISQQKASELMYKLFSEHIAFLLSLKNLPEEATLDCMLSICQVFENDNLHRGHSDEYTFAMLEQLLELSVKTLRQNTCWSTSWEMLSSLLAIDFDVLLPHSKILWECIKSVSHQDDIHALKFLKRWVRASAKARILDSFCIDWHLNVQTMSERSILTNRDFITSFSAVAEVSLSQISIKKLVTWLMSSESIMSENSNRFVVYYSLCKSLKRESYPAHLVPNFELFTRSIFNASLKNFNILDERSQALLCMCQISHVQFFSSDMSISASVGMKTLFEDLMAEKSRGLSSTVWSLQLLLCYLEQCLRLNTLHEDTTFPMRVVNYALEYSSKALDKFAENSHLILLDMVDVGKPDLVLTLLCRWLHMVHLYSSRTSITSWIYSIASKFYFIDSLNLETKDSVLESNWERFISSTETYELDSIRDSLIDCLIRLLCYSSNNAIDPVSAPGNLDFDNSAELCSSLTRFTPKNIDFVLKSLIHIPIHSITKNQRTRLLNLLIIHEKLLSDKDNSAHISLRKIIYTLMKTPCSSGFYRDPKIIIDLMQFGKTDLSFHKVHVLIMRSWIQHLDEGNKSEVILKLLQLILADFRELPLETITLIFNALVDSLPTSKHIKNSNDILSSVFTINDMLIDEMTAYLSKKESLCSGTFSCLLACCNSVLRTQNLTSESLNKLHILKVGIEEKAISLKLNELPFLENWILFQCLLSFGGDDFLKVVAYMVYYRRTVGEMSFRVSDFELALSRLSTNDADYAILNILNLLTSNECDEFDYSVLMKVVGVFANYSDCFQRNRHLVHMVLLCCTHVFYNQTLKPATLIDSALDVFLCFVQKTSKFISLDSFNTILTALSTILNLKELECEPKDHANLILKIIQILNGLLFNHRSYMSGRFHVFYSILKSLLYSMVQHDSEMKKIKGIALMNFYKPKKVPIHVVQSFCRLLTTWMNPNLMHDSNKKNSSLTDAERLFVKATTKHFVFLLTDFMSAQTVYQIDIQVKELLTNCFYNVYENLSNHEKQMALVAMNAPSKSLYQKFVNDYLIFAKWNEA
Protein: Zinc finger protein hangover (Q9VXG1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine.
Subcellular location: Nucleus {ECO:0000269|PubMed:16094367}.
Interaction partners:
Sequence:
MCDAAAATATTTTTAAVAAAVATTTASVALEATATQPGTTTTTVATASAGTTSPEAAIPTAATATSARNSNSERSARQNCCRLCIAPQTECISIINSYAADKEPLSTKIHNCVGIKVTPQDRLSQQICHACISYLNSWQSFKNRCFSSQAKQRQWLDTNKSKLLNYLDLNSAENGGGGFFDQHLHQQQQHHQHLENELEAEKEKATPTAASTAANILDGIHSLKKRKSLTVYPLPAMPIKDEPIDTDDDYQMKSIDESDDMVDPTMFLERSEHEGDVPLTASDYDYTAQHGVNASSVAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPHNTPITKPTPALAAALEMQRAAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVRKKYPQLPRNLCFNCLKMNDSKALFISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATTTDKLTNPDEEDSDDLDEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGEDEDEEGDGGEGEDEEGVQPPAQLLPQQQHKTDLNLNQDDDDLVEEVISSDDDEDDDGEVESDDDDEDDDDEEDDVEEPEPVGLTVRPLMNGKSKMPPLIVASSDDEDDGVMPIEDIIEEEFDEDADPDPEDAIEEVDEDDLDEGEVEDEPNVVSTASFSESESSTTTTSNSHSHSHSTGERRKKAVDQLNDPGFTCDLCQLCFDSQELLQSHIKSHILNGPKLSTVSAAAAAAAAAATASSKATALLTAAKAKPDSKSAVLANNNNSKTSSKTVAAGATN
Protein: Cell division ATP-binding protein FtsE (O05779)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter FtsEX involved in cellular division. Has ATPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:A5U7B7}; Peripheral membrane protein {ECO:0000250|UniProtKB:A5U7B7}; Cytoplasmic side {ECO:0000250|UniProtKB:A5U7B7}. Note=Associated with the membrane through an interaction with FtsX. {ECO:0000250|UniProtKB:A5U7B7}.
Interaction partners:
- Cell division protein FtsX
- SsrA-binding protein
- Uncharacterized protein
- Signal recognition particle receptor FtsY
- Cell division protein FtsZ
- Conserved protein
- Signal recognition particle protein
- Cell division protein FtsQ
- Peptide chain release factor 2
- Possible conserved transmembrane protein
Sequence:
MMITLDHVTKQYKSSARPALDDINVKIDKGEFVFLIGPSGSGKSTFMRLLLAAETPTSGDVRVSKFHVNKLRGRHVPKLRQVIGCVFQDFRLLQQKTVYDNVAFALEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVLLADEPTGNLDPETSRDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVRDEQRGVYGMDR
Protein: Anion exchange protein (G5EDF4)
Organism: Caenorhabditis elegans
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Membrane {ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362035}.
Interaction partners:
Sequence:
MEEETDEESPAKIARSRSCEPPGSSSRSRESRGSLWMSMGVHVENSRRRRMSKARRESQSIELSSLAPGTRVMFLLKEKENTPALFTEMGELNNEEWRETARWVKFEEDVEQGGNRWSKPHVATLSLHSLFQLRSCIMNGHFMNDLAETDIPSIFNAVIENLEKSGDLPSENREELREILLRKHVHQYEQAKKNGAGGEKGGFLSTVRSISDIGKSFSHGKNLSKIEEKPEGPVTSQTAGAPSGSSNQLTLPTVESVPKDISSEESSKGNLHFLKKLPAGVEASNVLIGEVDFLTRHICCFIRLKNANQLGDLTEVPVPTRFIFLLLGPTGHGQQYREIGRAIATLMADEIFHDVAYGARDVDDLLDGIDEFLDQVTVLPPGEWDPNIRIEPPSKLPSQEKRKQIGQELLVEPSSHKHVKKVVEEEEIHSHGDDPALKRTGKLFGGLILDIKRKAPHFVSDFTDAFNLQCLASICFMYFGLLAPIVTFGGLLEEATHQRMAAMENLFGGALCGVIYHFFAGQPLTIVGSTGPVLVFETIVFDFCHRFGIVYLSFRFWVHVWTAVIIFLMVVTDASALVSFITRFTEESFATLIAVIFIYEAIMKLVKIKGQLDMINYSRDFVEGGFCSCVPPIGKPSVSPDHARLVIKSTGLPIAFNDTFIDYTAANLTDCRTIGGSFDGTTCFPLYDKLLMSILLTVGTFFLATTLKKMRNSCYFPSSVRQLLSDFAVMIAIASMTFVDIFVGVNTPKLNVPSTFRPTWEGRGWFIPPFDANEWWTAPLAILPALLACILIFMDQQITTVIVNRKENKLKKGCGYHLDLLVLSVSILMVGFLGLPIYVAATVLSINHINSLKVESECKAPGEVAQFVGVREQRVTGIVTFLIIGLSVLATNILGRIPMPVLYGVFLYMGISALGGIQLFDRTLLLFMPMKYQPDTIYIRHVPIRKIHLFTAFQIGCLALLWVIKSIKSTSILFPIMLVVMVAIRKMMEKAFTTTDLKYLDDPMPDFHLRKKEDAKRRQSEGEAVEIEFDNENQATIHAVKTEAHLHIPMASGNVIKIPLAAIQEPSHSINLTKEVNNSGMWKHITSVDSKNSLVRDVPASSDPTSSRDAPIEQPEDDDDPIMIKVIRPSPHTSTSNLTTENTPLLKDEEPPKTNPDEPKV
Protein: Cardiac peptide (Q78AW6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003686}.
Interaction partners:
Sequence:
MVRTAVSWGLLLLLCQQTLVAAHVLGRPYPDSDLAQLKNLLERFEENLAAVATADDPAVDYEGPNPEPEHSKASPEWDRAPEAPQRPLLSDVRELAADESYSRAQSQRSRLQDLLMATRSKAMSGCFGARMDRIGTSSGLGCSPKRRS
Protein: Semaphorin-2A (Semaphorin-II) (Sema II) (Q24323)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ligand for transmembrane receptor PlexB. Plays a role in growth cone guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors. During embryogenesis, plays an important role in correct salivary gland positioning.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Plexin-B
- Plexin A, isoform A
- Semaphorin-1A
- Fasciclin-2
Sequence:
MSLLQLSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCVRDPYCGWDKEANTCRPYELDLLQDVANETSDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDAHRCTPPNKSNDYQKIYSDWCHEFEKYKTAMKSWEKKQAQCSTRQNFSSNQHPNEIFRKPNV
Protein: Tachykinin-related peptide 5 (TKRP-5) (P86598)
Organism: Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
APVMGFQGMR
Protein: Glutathione hydrolase proenzyme (EC 2.3.2.2) (EC 3.4.19.13) [Cleaved into: Glutathione hydrolase large chain; Glutathione hydrolase small chain] (F8SVM6)
Organism: Bacillus pumilus (Bacillus mesentericus)
Interaction partners:
Sequence:
MNRISLTILSICLLVFSFFLPVSQVTANEPHGNKVAVGKDGMVATAHPLASEVGADVLKKGGNAVDAAVAIQYALNVTEPMMSGIGGGGFMMVYDGKTKESSIINSRERAPQGATPDMFLTDDGKVIPFAERSTHGNAVGVPGTVKGLEAALDKWGTRSMKELIKPSIQLAEDGFEIDSVLAKAIDDHQGKLKKTAAAPIFIPNDQPLKEGDLLVQPRLAKTFKLIAKKGSKAFYEGKVAKALANTVQDFGGTMTTVDIARYEVDTDKPIWGDYKGYHLASMPPPSSGGVFMLQMLKILDHFNLSQYDPKSFEKYQLLAETMHHSYADRLAAYAGDPEFVDVPLNGLLDDLLDYISERASLIQLDQKNRNPVKEGDAWAYEDEKNPSPIVSQPEDKTIGETTRFKNSFFSFIVADQWGNVVSFTTTIEQLFGTGILVPEYGFFLNNELTDFDARPGGANEVQPNKRPLSSMTPTIIFKDNEPVMTVGSPGGSTIIASVSQTILNLLEYEMELQDAVEEPTIYTNSPTSYGYEVGVPLDVRTKLNDLGHRFGNSPIDIGNVQALLIDRKAGTFTGVADSSRNGTAVGVNIKVSAQK
Protein: Fluoride export protein 1 (Q08913)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26055717}; Multi-pass membrane protein {ECO:0000269|PubMed:26055717}.
Interaction partners:
- Putative uncharacterized protein YOR392W
- Uncharacterized protein YOR389W
- Uncharacterized membrane protein YOR365C
- Histone H3-like centromeric protein CSE4
- Histone H3
- COMPASS component SWD1
Sequence:
MIFNPVISNHKLSHYIHVFCTFTTFCILGTETRQAITALSTYTPAFVTAPTVLWSNCSSCMLMGIMQSLNAYTWMKDHQVLFLGVTTGYCGALSSFSSMLLEMFEHSTNLTNGNIANHTKLPNRAYGIMEFLSVLLVHLMVSMGSLIFGRQLGKEVIVAYGSSSFSKPYTPPSDTVKENAGDVDTQEMEKNILEFKFKTPAPFFKKFFDIVDKLAYALAFPLIILFVVLCAYYENYSRGKWTLPCLFGIFAGFLRYWLAEMFNKTNKKFPLGTFLANVFATLLIGIFTMVQRGKKHFSTDVPIVNSLNSCHIVSALISGFCGTLSTISTFINEGYKLSFINMLIYYTVSIAISYCLLVITLGSYAWTRGLTNPIC
Protein: Protein SCO1 homolog 2, mitochondrial (Homolog of the copper chaperone SCO1 member 2) (HCC2) (Q8LAL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX (By similarity). Participates in copper and redox homeostasis.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 2
- Cytochrome C oxidase assembly factor
- Heme A synthase COX15
- Cytochrome c oxidase assembly protein COX11
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 3
- Ankyrin repeat family protein
- Elongation factor G, chloroplastic
Sequence:
MLPCRRLVLSCKNQAASFLRRCGPSKRIQSVNYCKSTRQGHEIPDVKPLFPTGGGTQAPSRSRARYAVPAILLGFAGFVGFLHYNDERRAVPRGQASSNSGCGCGSNTTVKGPIIGGPFTLVSTENKIVTENDFCGKWVLLYFGYSFSPDVGPEQLKMMSKAVDKLESKHNEKILPVFVTLDPQRDTPSHLHAYLKEFDSRILGLTGTASAMRQMAQEYRVYFKKVQEDGEDYLVDTSHNMYLINPKMEIVRCFGVEYNPDELSQELLKEVASVSQ