wanglab/gogpt-training-data huggingface dataset:
Protein: Photosystem II CP43 reaction center protein (PSII 43 kDa protein) (Protein CP-43) (P56778)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01496, ECO:0000269|PubMed:11113141}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01496, ECO:0000305}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II reaction center protein H
- Cytochrome b559 subunit beta
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein T
- Photosystem II protein D1
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Chlorophyll a-b binding protein CP26, chloroplastic
- Photosystem II reaction center protein Z
- Photosystem II reaction center protein K
Sequence:
MKTLYSLRRFYHVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGVGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICIFGGIWHILTKPFAWARRALVWSGEAYLSYSLAALSVCGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLSTSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
Protein: Serine protease K12H4.7 (Q18198)
Organism: Caenorhabditis elegans
Interaction partners:
- Putative phospholipase B-like 2
- EGF-like domain-containing protein
- Carboxypeptidase
- Galectin
- EGF-like domain-containing protein
- DUF19 domain-containing protein
- Carboxypeptidase
- C-type lectin domain-containing protein
- Dietary restriction down regulated
- Serine carboxypeptidase ctsa-4.1
Sequence:
MKSLNLLLVLGALFAHSESARHPHLPPYLLGRPTEHGFVRHGDRFFTNFDTPAPNLNRSTISQKVDNFDANNNAMYNQRYWYNPTFTQNKNIVFLMIQGEAPATDTWISNPNYQYLQWAKEFGADVFQLEHRCFGQSRPYPDTSMPGIKVCTMTQALADIHNFIQQMNRRFNFQNPKWITFGGSYPGTLSALFRQQYPADTVGAVASSAPLDWTLDFFEYAMVVEDVLKKTSVDCWRNVNQAFLNMQQLSLTKAGIQQLNTYFNLVPAFVDGQYTQHDIDNFFANVYSFFQGVVQYTYDGRNNATLNGLNAQQLCNKMNDATVPDVITRVNNTINWINQMNGDPVGPFQNSYSDMMTVLANASYDDNSAVPGDIAANRGWMWLCCNELGALQTTDQGRNIFQQTVPLGYFIDMCTDMFGADIGIKYVRDNNKQTLYKYKGADNYQATNVVLPNGAFDPWHVLGTYNNDTANHMTPLLIQGAAHCSDMYPTYPGEPTDLAKNRAIIHNELKYFLGIS
Protein: Phosphoglycolate phosphatase 2 (EC 3.1.3.18) (Q8GWU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dephosphorylates 2-phosphoglycolate, but does not contribute to photorespiratory metabolism.
Interaction partners:
- Glycerate dehydrogenase HPR, peroxisomal
- Peroxisomal
- Glycolate oxidase 3
- Peroxisomal
- Glycolate oxidase 2
- Glycolate oxidase 1
- Glyoxylate/hydroxypyruvate reductase HPR3
- Glyoxylate/hydroxypyruvate reductase A HPR2
- Ribulose bisphosphate carboxylase large chain
- Phosphoglycolate phosphatase 1A, chloroplastic
Sequence:
MAPQLLSSSNFKSLFDSVDTFLFDCDGVIWKGETLIDGVSQTLDLIRSKGKNVVFVTNNSVKSRRQYAEKFRSLGVTSITQDEIFSSSFAAAMYLKVNNFPKDKKVYVIGGEGVLEELQIAGFTGLGGPEDGEKKAQWKSNSLFEHDKSVGAVVVGLDPNINYYKLQYGTLCVRENPGCLFIATNRDAVGHMTDLQEWPGAGCMVAAMCGSTEREPIVVGKPSTFMMDFLLQKFGTETSRMCMVGDRLDTDILFGQNAGCKTLLVLTGVTSESNLLDKGNKIEPDYYTSTVSDIIKLMESP
Protein: Trafficking protein particle complex subunit BET3 (Q5ARJ4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222, ECO:0000256|PIRNR:PIRNR018293}.
Interaction partners:
- TMEM1 family protein, putative
- Trafficking protein particle complex subunit 2/Sedlin, putative
- PutativeTRAPP
- Trafficking protein particle complex subunit
- Hypercellular protein A
- Trafficking protein particle complex subunit
- Transport protein particle
- Trafficking protein particle complex subunit 11 domain-containing protein
- GTP-binding protein ypt1
- DUF974 domain protein
Sequence:
MSSTKVSRIGEENKIDKVNAELVTLTYGTIVAQLCQDYDGNYPEVNKQLEKMGYNIGMRLIEDFLAKSNAQRCANFRETADMISKVGFKIFLNITPTVTNWASDNNQFSLIFDENPLADFVELPDDGRAQDELWFSNILCGILRGALEMVQMQIEAHFVSDILRGDDTTEMRVSLVRYIEDEVPPESD
Protein: Metal homeostasis factor atx1 (O74735)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Shuttles copper to the transport ATPase ccc2. Protects against oxygen toxicity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Copper-transporting ATPase ccc2
- Protein sco1
- Superoxide dismutase 1 copper chaperone
- Copper amine oxidase 1
- Rsm22-cox11 tandem protein 2
- Cytochrome c oxidase copper chaperone
- Copper transport protein ctr5
- Copper transport protein ctr4
- Mitochondrial inner membrane protein oxa1-2
- Rsm22-cox11 tandem protein 1
Sequence:
MKYQFNVAMACDGCKNAIDRVLTRLGVEDKSISVEKQEVIVTTDKPYELVEQTIKKTGKEVRSGKVLE
Protein: Dienelactone hydrolase (Q9A405)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
Sequence:
MSLRALFAAASLAVAAFAPPALADNAGFMVLRQPRAEGPPVEVGIWYPTDAAASPMRLGLNAHTVAAGAPVVGEHLPLIVMSHGNGGSFAGHADTAQALAEAGFVVAALTHPGDNYKDQSRATAMADRPAALSSLIGWMLEASPLKAKLDPAKVGAFGFSSGGFTVLAAAGGEPDLSRMLGHCLKHPANFDCKLTANRPAPANVLAARWTHDPRIKAVVAAAPALGFTFGKRGLKGITAPVQLWKAGDDQILPGDDYAEAVHRNLKRPHDYRVVPGAGHFDFLAPCAPTPPAELVYLCASAPGFDRKAFHQTFNTEVVRFFTHQLVAPAKTAQKR
Protein: UDP-arabinose 4-epimerase 1 (EC 5.1.3.5) (UDP-D-xylose 4-epimerase 1) (Q9SA77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a UDP-D-xylose 4-epimerase but lacks both UDP-D-glucose and UDP-D-glucuronic acid 4-epimerase activities in vitro.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12566589}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- UDP-sugar pyrophosphorylase
- UDP-D-apiose/UDP-D-xylose synthase 1
- UDP-D-apiose/UDP-D-xylose synthase 2
- Cellulose synthase-like protein D5
- UDP-arabinopyranose mutase 1
- UDP-arabinopyranose mutase 2
- Galacturonokinase
- L-arabinokinase
- Xyloglucan galactosyltransferase MUR3
- Thylakoid lumenal P17.1 protein
Sequence:
MFSFGRARSQGRQNRSMSLGGLDYADPKKKNNYLGKILLTASLTALCIFMLKQSPTFNTPSVFSRHEPGVTHVLVTGGAGYIGSHAALRLLKESYRVTIVDNLSRGNLAAVRILQELFPEPGRLQFIYADLGDAKAVNKIFTENAFDAVMHFAAVAYVGESTQFPLKYYHNITSNTLVVLETMAAHGVKTLIYSSTCATYGEPDIMPITEETPQVPINPYGKAKKMAEDIILDFSKNSDMAVMILRYFNVIGSDPEGRLGEAPRPELREHGRISGACFDAARGIMPGLQIKGTDYKTADGTCVRDYIDVTDLVDAHVKALQKAKPRKVGIYNVGTGKGSSVKEFVEACKKATGVEIKIDYLPRRAGDYAEVYSDPSKIRKELNWTAKHTNLKESLETAWRWQKLHRNGYGLTTSSVSVY
Protein: Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin) (Q96GR2)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10954726}. Cytoplasmic vesicle {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:24269233}. Cell membrane {ECO:0000269|PubMed:24269233}.
Interaction partners:
- Fatty acid synthase
- ATP-binding cassette sub-family D member 1
- Long-chain fatty acid transport protein 2
- ATP-binding cassette sub-family D member 2
- Palmitoyl-protein thioesterase 1
- Lysosomal thioesterase PPT2
- Lysosomal cobalamin transporter ABCD4
- Monoglyceride lipase
- ATP-binding cassette sub-family D member 3
- Lipoprotein lipase
Sequence:
MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHALELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLIALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDLKPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQEQKM
Protein: Syntaxin-4 (Q08850)
Organism: Rattus norvegicus (Rat)
Function: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:32963038}; Single-pass type IV membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:32963038}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P70452}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000269|PubMed:32963038}.
Interaction partners:
- Vesicle-associated membrane protein 8
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 2
- Syntaxin binding protein 3
- Vesicle-associated membrane protein 3
- Vesicle-trafficking protein SEC22b
- Vesicle-associated membrane protein 7
- Vesicle-associated membrane protein 1
- Vesicle-associated membrane protein 4
- Alpha-soluble NSF attachment protein
Sequence:
MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLSSPDDEFFQKVQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLKAIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMIAICVSVTVLILAVIIGITITVG
Protein: Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) (Q68EM7)
Organism: Homo sapiens (Human)
Function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
Subcellular location: Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
Interaction partners:
- Angiomotin
- Cell division control protein 42 homolog
- InaD-like protein
- Cdc42-interacting protein 4
- Angiomotin-like protein 2
- Angiomotin-like protein 1
- Protein PALS1
- Partitioning defective 3 homolog
- SH3 domain-binding protein 1
- SH3 domain-containing kinase-binding protein 1
Sequence:
MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL
Protein: Large ribosomal subunit protein uL29m (Q27370)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MPMQMHTSAVRRDLMEFFDDKKNWSENEVKVGRAGHGGAAYQVQQGAAPAVVRAPQGSNMLLTMEHECNDKMEVFPSPERIDKVKISMENLETVVRERNKAYHLLETGETGERPQKAVKNAFGLQVSYKACEHALPPFMNLKWIKSRNIGYGGRAVNRFLLKYREKLYNAKRKAKKYVALS
Protein: E3 ubiquitin-protein ligase RKP (AtKPC1) (EC 2.3.2.27) (Protein RELATED TO KPC1) (RING-type E3 ubiquitin transferase RKP) (Q9SIZ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of KRP1 and KRP2.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme atg7
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin-like modifier-activating enzyme 5
- RNA-binding
- E3 ubiquitin-protein ligase UPL4
- Nuclear cap-binding protein subunit 2
- Serine/arginine-rich splicing factor SC35
- E3 ubiquitin-protein ligase UPL3
- Ubiquitin-activating enzyme E1 1
- Ubiquitin carboxyl-terminal hydrolase 5
Sequence:
MAEDSLRVGMISSGLAVLLNGEDAKENSSKARIVPHFDYSGHRPLERTIEFIFGLAEKSVGPLDGQVDSSLIRAVIKNQFSKLHGDLDVSVSQREGISVVHHGVGPPIVGLEEFSICGDIRIVKPPLVLESLALFSSARANACIWKGKWMYEVALETSGIQQLGWATLACPFTDQKGVGDADDSYAFDGRRVSKWNKEAEPYGQSWVAGDVIGCCIDLNCDEIYFYRNGVSLGAAFTGIRKLGPGFGYYPAISLSQGERCELNFGAYPFKYPVDGFQPLQEAPTRFSFATELLRCFSRLLDRPDRSLADTLSRLRRFASVEELFCPVSSAICDEFFYILEQDPLLAEYLGRGAFLSFLLETFRTQAPHDSSSLDKVLDVFLEFPQSHLIFEHVVNALACGCKTATLILTECPYSGPYPYLALACHLFKREELMVQWWRSLHFEFLFEGFLSCRSSNKHDLQHLMPVVWWPGSSEDISYESSMGFTISALSEAINKIEEKQRNLCLLVIQFIPPVSPPQLPGSAFRGFLQNLLLKNRGADRTLAPSGVTRNSVLVSLFSVILHFLSEGFAMLKSSEAVHHNVGFLHRGGQQKFPLSLFLKNDPHRADITRLGGLFSHISKSYPTDDQEEEIMRWEEGCMDDEQNRVTHATEQKPCCCLAYDTDLTKSLKDRGKNTAQSSRGRCSSIPERSSHVAAECSAGSFSEEIDDKPSTSNQSDPDFGYRPVRFMRTALQESRISSAILSEEELLDALLLLYHIAVAPNFKQASYYMSHQSQSISLLEETDKQIRERASCDQIKRLKEARNNYKEDVMDCVRHSAWFRISLFSRWKQRGMYALCMWVVQLLLVLSKMDSVFVYIPEFYLESLVDCFHVLRKSDPPFVPSTTFIKQGLSSFITFVVTHFNDSRISNTDLKDLLLQSISVLVQYKEYLEAFENNEAATRHMPAALLAAFDNRSWIPVTNIFLRLCKGSGFSSLKNGESSFSSTVFQALLRDACINDGELLSTFLNRLFNTLSWTITEFSVSVREMQEKYQVMEFQQRKCCVIFELSSNLARVLEFCTYAMPQAFLAGTDTNLRRLTELILFILNHMTSAVDDEFFDLSLRRQGQPSEKVSRGILLAPLVGIILNLLEASEDSKPKQQHDVIGLFASMDCPDTVYYGFQYLLEYNWDGCVSGDDAYVKKLGQLENFLSHLINRASSQEPERKEESFNKDTTDIEDNTCCICYAGEANAMIAPCSHRSCYGCITRHLLNCQRCFFCNATVIDVIRDKEEEEEEDDDGHKRST
Protein: Thioredoxin X, chloroplastic (OsTrxx) (OsTrx16) (Q7XKD0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Thioredoxin reductase NTRC
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- 2-Cys peroxiredoxin BAS1, chloroplastic
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Thioredoxin-like protein CDSP32, chloroplastic
- Peptide methionine sulfoxide reductase A5
- Peptide methionine sulfoxide reductase A4, chloroplastic
- Peptide methionine sulfoxide reductase A2-1
Sequence:
MASAPSTTASGLAPPPFSSARGARLLPGALLRLPPPPASVGSFRVVGPAAAPPGGRRIASARVRCGAAVRFIGQSEFEAEVLQSDLPVLVDFVADWCGPCRLIAPVVDWAAEEYEGRLKIVKIDHDANPQLIEEYKVYGLPSLILFKDGKEVPGSRREGAITKAKFKEYLEPLLSTSTVA
Protein: Acyl CoA binding protein family (AFU_orthologue AFUA_2G11060) (Q5B0M6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MSVPTFTAALTASQNKEKYSAKVQELAAAINADALSSAIEAILSGGDDATVSDAEQSKALTAGFEYATELVKELKSSPGNDDKLKLYAFFKRSKNEEPAAPGAFSFEAKYKYNAWKEIKDISQQRAQALYIQKVNALLESIGTN
Protein: Cold acclimation protein COR413-TM1 (Q84XU9)
Organism: Triticum aestivum (Wheat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSISLRLVIPIAAPCPVPPPRTARNAGCSPLSAAAVPVRTTGALRGCAALPLRPQSLVRPCRSRGSGIVCNASAYLSPPTTQWVSVAAAAVLLLAKGTGIHKSFLVPLFVLQAPTAVISWIKSEYGLWTAFLALVVRLFLPFPGELELPLSTMLAVSVAPYQVMNVRGTQGGAIVSLALAAYLAFQHFTRTGGIGKAFDQGSIVATMAIICIAVINVILLF
Protein: Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) (O94992)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:16362050, ECO:0000269|PubMed:17395637}. Cytoplasm {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:17395637}. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050).
Interaction partners:
- 7SK snRNA methylphosphate capping enzyme
- Cyclin-T1
- Cyclin-dependent kinase 9
- La-related protein 7
- Protein HEXIM2
- Cyclin-T2
- Bromodomain-containing protein 4
- B-cell lymphoma/leukemia 11B
- Protein phosphatase 1G
- AF4/FMR2 family member 4
Sequence:
MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD
Protein: Histone H2B type 2-B (H2B-clustered histone 18) (H2b-616) (Q64525)
Organism: Mus musculus (Mouse)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H2A type 1-B
- Histone H3.2
- Histone H3-like centromeric protein A
- Histone H3.1
- Histone H3.3
- Ubiquitin-conjugating enzyme E2 D3
- Polycomb complex protein BMI-1
- Histone H2B type 1-C/E/G
- Histone H2A type 1-F
Sequence:
MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Q64433)
Organism: Mus musculus (Mouse)
Function: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P61604}.
Interaction partners:
- 60 kDa heat shock protein, mitochondrial
- Stress-70 protein, mitochondrial
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- GrpE protein homolog 1, mitochondrial
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Mitochondrial disaggregase
- GrpE protein homolog 2, mitochondrial
- Heat shock protein 105 kDa
- Lon protease homolog, mitochondrial
Sequence:
MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGGKGKSGEIEPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDSDILGKYVD
Protein: N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (N-acetylneuraminic acid phosphate synthase) (Sialic acid synthase) (Q99J77)
Organism: Mus musculus (Mouse)
Function: Produces N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) from N-acetylmannosamine 6-phosphate. Has no detectable activity towards N-acetylmannosamine or mannose 6-phosphate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10873658}.
Interaction partners:
- N-acylneuraminate cytidylyltransferase
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- N-acylneuraminate-9-phosphatase
- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
- N-acetylneuraminate lyase
- N-acylglucosamine 2-epimerase
- CMP-sialic acid transporter
Sequence:
MPLELELCPGRWVGGKHPCFIIAEIGQNHQGDIDVAKRMIRTAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYKELQSYAQEIGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDANLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPAGTTLTLDMLTVKVGEPKGYPPEDIFNLAGKKVLVTIEEDDTVMEESVESHSKKIKA
Protein: DnaJ heat shock protein family (Hsp40) member C7 (A0A6I8PU73)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAAAECDVVMAATEPELLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLELKKSKRKDYYKILGVDKNASEDEIKKAYRKRALMHHPGRVDRHSGASAEVQKEEEKKFKEVGEAFTILSDPKKKTRYDSGQDLDEEGMNMGDFDPNNIFKAFFGGPGGFSFEASGPGNFFFQFG
Protein: Glial cell line-derived neurotrophic factor (mGDNF) (Astrocyte-derived trophic factor) (ATF) (P48540)
Organism: Mus musculus (Mouse)
Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P39905}.
Interaction partners:
- GDNF family receptor alpha-1
- Proto-oncogene tyrosine-protein kinase receptor Ret
- GDNF family receptor alpha-2
- GDNF family receptor alpha-3
- BDNF/NT-3 growth factors receptor
- Neurotrophic factor BDNF precursor form
- NT-3 growth factor receptor
- High affinity nerve growth factor receptor
- Ciliary neurotrophic factor
- GDNF family receptor alpha-4
Sequence:
MKLWDVVAVCLVLLHTASAFPLPAGKRLLEAPAEDHSLGHRRVPFALTSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQAAALPRRERNRQAAAASPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCESAETMYDKILKNLSRSRRLTSDKVGQACCRPVAFDDDLSFLDDNLVYHILRKHSAKRCGCI