wanglab/gogpt-training-data huggingface dataset:
Protein: PsbA (C5MRM9)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
PWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRA
Protein: Eukaryotic translation initiation factor 4E-binding protein Mextli (Q9VR35)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in promoting translation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23716590}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:23716590}. Note=In germ line cells, predominantly cytoplasmic (PubMed:23716590). Accumulates in the perinuclear meiotic nuage (also known as germline granule or P granule) during oogenesis but disappears from there around stage 8 (PubMed:23716590). {ECO:0000269|PubMed:23716590}.
Interaction partners:
- Eukaryotic translation initiation factor 4E1
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
Sequence:
MAHTHLGRAVKNIEAPRPLKTQSRSSLKNSYLVIEELIQLIDNVTVGLQSCNTTPESITLLLHNLRVHGPQLEAVSKDTLDRAFVVFRNASQDERLNITTRLKLLELIELRAKSWDNDDTIAYYKSKQQISNVELPSEYQYDAGVQPGAFSTSPTFGVSGGVGGVNDGAAAAAAAVFNAASAAAAAQAAAIAAVGTSNQQHMLLPPGEVIRNSGKFPKPTKIPGKTYCKDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPAEDKINYAKQLMEDTIRRNASPVRLEPAPAVGGSCSSLNSSNSDDAIVQPRTPTGSSLANRLSFNSAQNFMTATAAAQQISQQMHHQTHHLQHQQQQQVAAVAAAAAAAAHAQATAAAGKVLRPNQQLLMHSYSTNDASVGEYKFTVNVGQHLIKITGDCCELVRVAKLVLDDYFSSSEFLASIEAGAAFDGTSLVTTPSTPLPGAGPPQFWLPGTDSGIGLNCVVSSSANNNGEGDDEVFAEPSNGGSSTSNQNGLARSRRSHFSRKESTPETKGAREKGDLDDLAGTNSLKSNASRVSYDIEHLLYYSMSPHSWTLPTDWQKMQETAPSILRNKDLQDESQRFDGDKYLASIKTAAKRDIVAADEVETLDE
Protein: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-2) (Q9DB30)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).
Interaction partners:
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
- Phosphorylase b kinase regulatory subunit alpha, liver isoform
- Phosphorylase b kinase regulatory subunit beta
- Calmodulin-1
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 3
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- Calmodulin-like protein 4
- Neuronal migration protein doublecortin
Sequence:
MTLDVGPEDELPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPRLFPIAATELEGDSGAITEDEATLVRS
Protein: NF45 (F4ZW62)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE
Protein: 40S ribosomal protein S26 (O96258)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 60S ribosomal protein L14, putative
- 60S ribosomal protein L28
- Ribosomal protein L15
- 60S ribosomal protein L24, putative
- 60S ribosomal protein L21
- 60S ribosomal protein L2
- Ribosomal protein L37
- 60S ribosomal protein L6, putative
- Ubiquitin-60S ribosomal protein L40
- 40S ribosomal protein S29, putative
Sequence:
MPKKRRNGGRSKHNRGHVNPLRCSNCGRCVPKDKAIKRFNIRNIVDTSAQRDIKEASVYSTFQLPKLYIKQCYCVSCAIHSRFVRVRSREQRRVRKETAKHVNPSQL
Protein: ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) (P28324)
Organism: Homo sapiens (Human)
Function: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
Subcellular location: Nucleus.
Interaction partners:
- Serum response factor
- Voltage-gated delayed rectifier potassium channel KCNH8
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 11
- Solute carrier family 45 member 3
- ETS domain-containing protein Elk-1
Sequence:
MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT
Protein: Atlastin-3 (EC 3.6.5.-) (Q91YH5)
Organism: Mus musculus (Mouse)
Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32075961}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. {ECO:0000250|UniProtKB:Q6DD88}.
Interaction partners:
- Microtubule-associated protein 1 light chain 3 beta
- Spastin
- Reticulon-3
- Gamma-aminobutyric acid receptor-associated protein
- Receptor expression-enhancing protein 1
- Cell cycle progression protein 1
- Testis-expressed protein 264 homolog
- Translocation protein SEC62
- ADP-ribosylation factor-like protein 6-interacting protein 1
- Endoplasmic reticulum junction formation protein lunapark
Sequence:
MLSPQRTAAVASRGAGDAMENGKPGPVQVVLVHKEQHSFELEERALASVLLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQKEGGHSDWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVKKPCGKKVAVVLMDTQGAFDSQSTVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKPFQTLMFLIRDWSFPYEYNYGLQGGMAFLDKRLHVKEHQHEEIQNVRNHIHSCFSDVTCFLLPHPGLQVATSPNFDGKLKDIASEFKEQLQALIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQATAEANNLAAAASAKDIYYNNMEEICGGEKPYLSPDILEEKHLEFKQLALDHFKKIKKMGGKDFSFRYQQELEEEIKELYENFCKHNGSKNVFSTFRTPAVLFTGIAALYIASGFTGFIGLEVVAQLFNCMVGLLLIALLTWGYIRYSGQYRELGGAIDSGAAYVLEQASSHIGNSTQAAVRDAVVGRPPADKKSQ
Protein: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (P9WFQ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable exodeoxyribonuclease III protein XthA
- Thiamine-monophosphate kinase
- Probable resolvase
- Probable transposase
- Possible conserved secreted protein
Sequence:
MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP
Protein: C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine) (Q9ERE0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q92583}.
Interaction partners:
Sequence:
MMSLQMLLLAALLLGTSLQHASAARATNVGRECCLDYFKGAIPIRKLVTWFRTSVECPKDAIVFETVQGRLICTDPKDKHVKKAIRHLKNQRL
Protein: Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) (P48200)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Subcellular location: Cytoplasm.
Interaction partners:
- F-box/LRR-repeat protein 5
- Citrate synthase, mitochondrial
- S-phase kinase-associated protein 1
- Transferrin receptor protein 1
- RanBP-type and C3HC4-type zinc finger-containing protein 1
- Natural resistance-associated macrophage protein 2
- Sentrin-specific protease 8
- Cytoplasmic aconitate hydratase
- Cysteine desulfurase
- E3 ubiquitin-protein ligase RNF31
Sequence:
MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS
Protein: MFS antiporter QDR1 (Q5A6P6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24621232}; Multi-pass membrane protein {ECO:0000269|PubMed:24621232}. Note=Preferentially localizes to membrane rafts. {ECO:0000269|PubMed:24621232, ECO:0000303|PubMed:19055746}.
Interaction partners:
- Pleiotropic ABC efflux transporter of multiple drugs CDR1
- Hexokinase-2
Sequence:
MPGNREEFDIEKVLKSKKLEAIETSTEKKAPYTVFESTDKLLLIIVLSLVGFWSAISSPIYFPALPTLTKYFNTTPSVMNISVVAYLIFQGIAPTISSNLADTFGRRPVILGSIIVFCAVCIAISQTNVYWLLALLRCFQAAGIAPVFAISSGVAGDICTPANRGGMVGAVSGLQLAGNGIGGLVGAALISGFHTWRAIFIFLAIGGGVTFIFAFLVLAETSRRIVGNGSIRPKNVLNKAVLIYLPHFKNKITNDYSTLQPKGPFDILGPFKIFFQKEVFCTLLPSGMHFAAWTVSLTSLSTELESAKYNYSVMKVGLVYLPQGIACFIGSLIAGRCLNWYYRYRKNLYDKQMNDVPLNDRPPFNLVASRLTLTIVPLAMMVIGLSAFGWCLEYKKPIISIIISTILISFSASVMMSICTTMLVDLYPKQSGASASCVNLMRCWLAALFTGVLDKIISALGLGGTYTLLTGICLLTDLGLVYVLYTANQRFVNYVSPNQTAVNSDAEDY
Protein: Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) (Octn1) (Q9Z306)
Organism: Mus musculus (Mouse)
Function: Sodium-ion dependent transporter of various organic cationic compounds. A key substrate of this transporter is ergothioneine (ET) (By similarity). Able to transport carnitine, probably moving one sodium ion with one molecule of carnitine (By similarity). Also transports tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:15832501, ECO:0000269|PubMed:20601551}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:16729965}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:Q9H015}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of small intestines (PubMed:20601551). Localized to the apical membrane of cortical proximal tubular epithelial cells in kidney (PubMed:15832501). {ECO:0000269|PubMed:15832501, ECO:0000269|PubMed:20601551}.
Interaction partners:
- Solute carrier family 2, facilitated glucose transporter member 9
Sequence:
MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNHSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSVDREESPKVLITAF
Protein: Synaptobrevin homolog YKT6 (Q2UHD9)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046280}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00046280}.
Interaction partners:
- t-SNARE coiled-coil homology domain-containing protein
- Sec1-like protein
- t-SNARE coiled-coil homology domain-containing protein
- Microbial-type PARG catalytic domain-containing protein
- Probable vacuolar protein sorting-associated protein 16 homolog
- t-SNARE coiled-coil homology domain-containing protein
- Scytalone dehydratase
- V-SNARE coiled-coil homology domain-containing protein
Sequence:
MASSSKPPSFLLYTCIAHRTTILAEHSSPGTSSTSASSLASIILPKITHEKSQKLTYTHERLFVHYIADSPTGASDDSSFRQEPNSYAPLSYIVVATAEQGRRIPFAFLLEMKRKFLSTYPPSSTDFAALPAYGCAAFNNELRSLLQTYNTAPPSDSLASARREIDSVRDIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRIRSRGLRRRMWWKNIKLMVLLGVVIVFLLYLFIGVGCGLPAWGKCVGHSE
Protein: Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein) (Q8J025)
Organism: Homo sapiens (Human)
Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20393562}; Single-pass type I membrane protein {ECO:0000269|PubMed:20393562}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-3a
- T-cell antigen CD7
Sequence:
MSWPRRLLLRYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTEAVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGCECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVLSSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEDLAEDSGSSLYGRAPGRHTWSLLLAALACLVPLLHWNIRR
Protein: Developmental regulator, ULTRAPETALA (F4JKJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANNEGEMQCGSMLFKQEELQEMSGVNVGGDYVEVMCGCTSHRYGDAVARLRVFPTGDLEITCECTPGCDEGLSFFVSTVSFSCLSDAFGKMGFDFFDCMMLDKLTPAAFEKHSGRETARKWKNNVWVIIGGEKVPLSKTVLLKYYNESSKKCSRSNRSQGAKVCHRDEFVGCNDCGKERRFRLRSRDECRLHHNAMGDPNWKCSDFPYDKITCEEEEERGSRKVYRGCTRSPSCKGCTSCVCFGCELCRFSECTCQTCVDFTSNVKA
Protein: Kelch-like protein 40a (Kelch repeat and BTB domain-containing protein 5a) (B3DIV9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9D783}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:Q9D783}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q9D783}.
Interaction partners:
- Kelch-like protein 3
- Kelch-like protein 21
- Kelch-like protein 40b
- Kelch repeat and BTB domain-containing protein 8
- Kelch-like protein 12
- Speckle-type POZ protein
- Speckle-type POZ protein-like A
- Speckle-type POZ protein-like B
- Peflin
- Bardet-Biedl syndrome 1.
Sequence:
MASMSVDPVTEPRMYQQTLLQDGLCDLLDANKFVDCILKIKDKEFPCHRLVLAATSPYFKAMFLSDLEESKKREIVLKDIEPGVMGMILRYIYTSDINLTEQNVQDIFMAANMYQIPSIFSVCVSYLQQKLVLSNCLAIFRLGLLLDCPRLAMEARDFICDRYLLIIRDQDFHQLGPSELAAIITCDSLNVEREESVFESLMDWVEYDTDERTKELPELLHCVRFRLMPTSYFKEKVEGHRLIRTNQELKKELQLIKDAQKGLLHRVKRSSHRKEGKSAEFESDDDDEDGLLPGILNDNPRFGMFQSDLILMINDAGTVAYDVGANECFVASSSTEIPKNHCSLVTKENQIFVVGGLRYNEENKDQPFSSYFLQFDPMSSEWLGMPSLPNPRCLFGLVEAENSIYVVGGKELKEGERALDSVMIYDRQSFKWGESDPLPYAVYGHGIVSHKGLVYVIGGKTESKKCLRRVCVYDPSKFEWKDLAPMKTARSLFGTAVHKNKIYVVTGVTDNGLTSTVEVYDIASNSWSEFVDFPQERSSLNLVELGGFLYAIGGFAMMPNETTEKLEPTEMNDIWKFDEEENCWNGILREIRYAAGATVLGVRLNTLRLTKI
Protein: Uncharacterized protein (Q57VS1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BTB domain-containing protein
- Profilin
- Uncharacterized protein
Sequence:
MFEGAGEGLNVRLATSIKLFLEPDADPSRNDAADTRGSASYASEELLSVADTLRKYANTDECASSPTAVASEEKRSPTAALAAPLRGDRNLRIPTRASEARPRSASNKMGKKTDRGRSAARPKAAQERKRLHQGRQGSKATRKQESAKEKQNEVVVSRAASRRARKHQARATAVSTLRDYTTATPANRKSFIESITVNENECWGAPPLEGSPEAKKQAHTSTMSPLPRRVARELYLKDAPTLDETSSQAPSQHHGFYSSPDLTFPRWDGFPNNSSKPVNDVTTGLSNEAGDALFHHFWGTSGEPPANVVFPGGSIHPSKITRLKEKSRHNDVWHVEDGTPAEKANLSSWKQPLQEFGDTEEKPGERGELAVTLANNRMTYTETFDDYQNVFYRLWSCSSSRGHIGFLKNLSDKAGATGAVGEQPNSLVACSAILRDPQGLLVSRNLNSMLFAVGSQRGPEGSLKKWWLASGGDSAATLDKQTILDQGSCVELSYAARILYVALLYIRTLGGFPTLQRITPLSDSSTVVEKENCLELVFATTRFSPGGKRGKGMQEVNFREERSVIVRSVLAEKSCVERFGKREVVHVLPLLNESVGDAPERVSMQTITSAAADKSFVGFHPRSDKQPTRGPEPSYTAAASSPTLNGSALNSLKEKAVDYGDIAVAFLMSVEASKLSGVLPEPMEIEGLRYRVFILDSCKNYRKPQVNVFKNEVGSDTERWINNRMGAFEIELLRKREEARAAQAAHLAQVSLQEMLLKINGPLGRFPWYRPMTIAESTLAKADKESSGTYCTHSDDVQTALPRFYQLRLPRLHQDLAYVMCNLLGISLTMVPCPASGGQSQPSSFYSE
Protein: Integral membrane protein GPR137 (Q17QQ5)
Organism: Bos taurus (Bovine)
Function: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q96N19}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium channel subfamily K member 4
- Coiled-coil domain containing 88B
- G protein-coupled receptor 135
- Mex-3 RNA binding family member C
Sequence:
MESNLSGLVPAAGLVPALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANHLGPLPFWLLYCCPVCLQFFTLTLMNLYFAQVVFKAKAKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAMLSRRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLAALALAPRSRLDAFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSRILNGQVFGSRSYFFDRAHCEDEGCSWEHSRGESTSMSGSLGSSSWYGTIGREPGWCGGSQTRTTPLLFSQVLGPGGHHHSLYSTPQT
Protein: Profilin-1 (Pollen allergen Art v 4.01) (allergen Art v 4.01) (Q8H2C9)
Organism: Artemisia vulgaris (Mugwort)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). Possesses high binding affinity for poly(L-proline).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9FR39}.
Interaction partners:
Sequence:
MSWQTYVDDHLMCDIEGTGQHLTSAAIFGTDGTVWAKSASFPEFKPNEIDAIIKEFNEAGQLAPTGLFLGGAKYMVIQGEAGAVIRGKKGAGGICIKKTGQAMVFGIYDEPVAPGQCNMVVERLGDYLLDQGM
Protein: Olfactory receptor 2M7 (Olfactory receptor OR1-58) (Q8NG81)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- G protein-coupled receptor kinase 3
- Guanine nucleotide-binding protein G
Sequence:
MAWENQTFNSDFLLLGIFNHSPTHTFLFFLVLAIFSVAFMGNSIMVLLIYLDTQLHTPMYFLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYISLLGSECFLLAVMSYDRYTAICHPLRYTNLMRPKICGLMTAFSWILGSTDGIIDAVATFSFSYCGSREIAHFCCDFPSLLILSCNDTSIFEEVIFICCIVMLVFPVAIIITSYARVILAVIHMGSGEGRRKAFTTCSSHLMVVGMYYGAGLFMCIQPTSHHSPMQDKMVSVFYTIVTPMLNPLIYSLRNKEVTRALMKILGKGKSGD
Protein: Binder of USO1 and GRH1 protein 1 (Q12191)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ER to Golgi vesicle-mediated transport by either facilitating USO1-dependent and -independent tethering or increasing target accuracy of fusion events of COPII-coated vesicles.
Subcellular location: Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Note=Localizes to cytoplasm in a punctate pattern. Localizes to cis-Golgi together with GRH1.
Interaction partners:
- GRASP65 homolog protein 1
- Intracellular protein transport protein USO1
- Integral membrane protein SED5
- Protein SLY1
Sequence:
MSEQESDEVKRMKQLEEARKRVEELKKKKNKKNKGKKNKNSSATGSIGSETPDLEGTPGEESTQEETVKANSTKSENNDQNDVDEESEEKEIEQVKSDPSGTTEKDIEEINSTSSNVGKDDAENTKKEEVQEVIKNNNDEQTADAGKTIEPQEEKKIVQTQEGNEPSNTSEAADDLFANDGNEESDFLTTIKKQKEEDELTKLRAENEKLTQENKQLKFLNMENETTVDDLQDQLQEKEDIINGLQNDLQTARDELIAAVEKLKLAEAKAARNTTATPIQFADFNTSSNNLTPSQSVTNSGTQVAHGNNMEVDRVMLNKWRQWNVDMTTWRSIGSGPIMEF
Protein: Kl-2 protein (Q281X0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EYKPASERASILFFVLMDMSKIDPMYVFSLAAYILLFTQSIERSPRNQLVHERIQNINEYHSYAVYRNTCRGLFERHKLLFSIHMTAKILSNAGKLLEEEYDFILKGGIVLDKLGQAPNPAPWWISEQNWDNITELDKVSGFHGIIDSFEQHYKAWNGSWYATTFPEQEDLVGEWNDKLTDFQKICVLRSLRPDRISFCLTQFIITKLGPRYVDPPV
Protein: ATP-dependent DNA helicase II subunit 1 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku70) (O94395)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Required for mating-type switching (By similarity). Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000269|PubMed:12424244}.
Interaction partners:
- ATP-dependent DNA helicase II subunit 2
- DNA ligase 4
- Double-strand break repair protein rad32
- Exodeoxyribonuclease 1
- Telomerase reverse transcriptase
- DNA repair and recombination protein rad22
- Serine/threonine-protein kinase chk1
- DNA ligase 3
- Protein kinase rad3
- DNA repair protein rhp51
Sequence:
MENDEQIDETENFAIGKYAILFVIEVSPSMLDPVDEFTPSSLQMALICAYQLAAQRVITNPSDIMGVLLYGTESSTGRFANQMMLLDIDPPDAERIKSLQSFEKDFQFSKEKFKPCSCQVSLSSVLYHCSVIFTTKAENFEKRLFLITDNDHPAWDATERDIILQRAKDLRDLDIQVHPVFLDPPTHSFRINIFYSDFLYIVYGRQDVSNLVNRGQAQLQHMLNMITALQKPKRAHFHLKMDLGNDVRIGVEAFILLKRLESAKTNWVYAKGERFAVAVPQSKQVSFATKKELKKDEIRRSYSYGGSSVVFGSDELNKVRSFEPPTLRIIGFRDFSTLKPWHCLKPAVFLRPKDDEIIGSGAVFSAIHKKLLASNKIGIAWFVSRPNANPCFVAMLATPGSIHIRDDFELPLGIFLVQLPTADDIRSLPPINPNPISMPSNLIETMQRILRGMELRSYQPGKYNNPSLQWHYKVLQALALDEEIPTDFVDNTLPKYKAIQKRVGEYMGDVNNIVAEYRNDISDKNGIKEEEEDQGPIVKKARIEKSGKPIFAEDDRLKQLYIEGVLDKEIKALKVSQLKDILRDRGLRVSGKKADLLDNLTNYVKKL