wanglab/gogpt-training-data huggingface dataset:
Protein: Teratocarcinoma-derived growth factor 1 (F1Q691)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Nodal-related 1.
- Receptor protein serine/threonine kinase
- Left-right determination factor
- Forkhead box protein H1
- Epidermal growth factor.
- Serine/threonine-protein kinase receptor
- Nodal-related 2.
- Left-right determination factor.
- Southpaw.
- T-box transcription factor T-A
Sequence:
MTSQLFGFLMFAVIICQAVSLESGCEGSECVKVGVSGKPKQYAEFLNKFNEMNTQTPQRQHRNAEAALPFVGLTGVAKQSRTCCKNGGTCILGSFCACPKYFTGRSCEYDERLRDCGVIPHGEWVQKGCSYCRCGYGLLHCFPHVFSKDCDVFSKDCDDSQEVRWHRSGSLRTLSSTIVMFAPFILHRLL
Protein: Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) (O35165)
Organism: Rattus norvegicus (Rat)
Function: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:14742712}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:14742712}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9094723}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. {ECO:0000269|PubMed:14742712}.
Interaction partners:
- Vesicle-trafficking protein SEC22b
- Syntaxin-5
- Golgi SNAP receptor complex member 1
- BET1 homolog
- BET1-like protein
- Sec1 family domain-containing protein 1
- General vesicular transport factor p115
- Synaptobrevin homolog YKT6
- Alpha-soluble NSF attachment protein
- Vesicle transport protein USE1
Sequence:
MEPLYQQTHKQVHEIQSHMGRLETADKQSVHLVENEIQASIDQIFSHLERLEILSSKEPPNRRQNAKLRVDQLKYDVQHLQTALRNFQHRRQAKEQQERQRDELLSRTFTTNDSDTTIPMDESLQFNSSLQNIHHGMDDLIGGGHSILEGLRAQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCAVMFLVVQYLT
Protein: Peptidase S1 domain-containing protein (Q8MLS8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLRSLPIFLALFVLSKSDTGAGEDSEEDDENDCNRTTLGGHPVNITTAPWIASISIKQKAKCDGAIYKLSHIVTAGKCVDGFLNKVIRVRVGSTTRSDGVIEVAVCNITVHEKFTGQTVFHNVAILKLCEPLEASKTIQPIQLANQLPSNGAKVTANGWPSFRWWAMYWKKCLDDEAYKLQKAEVKLLGPSQCTDLWARNNWSKKNFTDDLFCTEKFAKEACSLAMGSPVVHNGKLVGIITKGGCSEYPEVYINLIKYKDWLHNHTK
Protein: Core-binding factor subunit beta (E1B9S8)
Organism: Bos taurus (Bovine)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Runt-related transcription factor
- Runt-related transcription factor
- Cullin-5
- Runt-related transcription factor
- Elongin-C
- Elongin-B
- type I protein arginine methyltransferase
- Single-stranded DNA cytosine deaminase
- non-specific serine/threonine protein kinase
- CMP/dCMP-type deaminase domain-containing protein.
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDFEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSSLGGGDDLKLR
Protein: SD07888p (Q95SU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046278}; Lipid-anchor {ECO:0000256|ARBA:ARBA00046278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00046278}.
Interaction partners:
Sequence:
MKNVITRVKGSQPAPILLVANKFDLDCQREVSTAEGRHHPYPSPDETALIYATVFLVLIGNALAQLWDCPFIEASAKDRINVNEVFATIVREMNLTQENRQKKNYCCCTLL
Protein: Cystatin-A2 (Q65YR7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Intracellular thiol proteinase inhibitor. Inhibits cathepsin B, but not papain.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15255188}.
Interaction partners:
Sequence:
MTKVGGLGATHQADKTVEDIVNAVKPSIQSKLGTNISNLKVISYKTQLVNGTNYFVKVRTENGYAHLRIYKPFSGAASLVSVQDGKAKDDEITYF
Protein: Putrescine importer PuuP (P76037)
Organism: Escherichia coli (strain K12)
Function: Involved in the uptake of putrescine. Imports putrescine for its utilization as an energy source in the absence of glucose.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Gamma-glutamylputrescine synthetase PuuA
- Putrescine transporter PotE
- Gamma-glutamylputrescine oxidoreductase
- Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD
- NADP/NAD-dependent aldehyde dehydrogenase PuuC
- 4-aminobutyrate aminotransferase PuuE
- HTH-type transcriptional regulator PuuR
- Spermidine N
Sequence:
MAINSPLNIAAQPGKTRLRKSLKLWQVVMMGLAYLTPMTVFDTFGIVSGISDGHVPASYLLALAGVLFTAISYGKLVRQFPEAGSAYTYAQKSINPHVGFMVGWSSLLDYLFLPMINVLLAKIYLSALFPEVPPWVWVVTFVAILTAANLKSVNLVANFNTLFVLVQISIMVVFIFLVVQGLHKGEGVGTVWSLQPFISENAHLIPIITGATIVCFSFLGFDAVTTLSEETPDAARVIPKAIFLTAVYGGVIFIAASFFMQLFFPDISRFKDPDAALPEIALYVGGKLFQSIFLCTTFVNTLASGLASHASVSRLLYVMGRDNVFPERVFGYVHPKWRTPALNVIMVGIVALSALFFDLVTATALINFGALVAFTFVNLSVFNHFWRRKGMNKSWKDHFHYLLMPLVGALTVGVLWVNLESTSLTLGLVWASLGGAYLWYLIRRYRKVPLYDGDRTPVSET
Protein: Mitochondrial inner membrane protease ATP23 (EC 3.4.24.-) (Q38AZ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASVEPDGVGNLSRKQPSIHEICEAAVDEVLANVNTVQYLIKSIEEISNTPFRRERIKCVPQLDSGGVANASWAGGSNTMADGTSAAGYMWRRARRDCEKGDILLIEQHVVLDKATENDSIVPGAKTCTAVERNLRHELIHAFDDARGIIEASDCMHQACSEVRAARLSGDCFVGEEMRRGRFDLLSGGIQCVRRRAITAVEKNPLCRGFSERAVERIFKQCYSDYEPFAAPLYSMGSYGDEKFEL
Protein: Protein odd-skipped-related 1 (XOsr1) (P86413)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor. Required for pronephric kidney development.
Subcellular location: Nucleus {ECO:0000269|PubMed:17011543, ECO:0000305}.
Interaction partners:
Sequence:
MGSKTLPAPVPIHPSLQLTNYSFLQAFNGLPVPAEHVPNLYGFSALHAVHLHQWTLGYPTLHLPRSSFSKVPGVSSLVDSRFQIPTFPLFPHMIHPKQESPNLSNKTKPRFDFANLAVAATQEDHCKLGLMNDQGSPPAMGGLLDVTKLTPEKKPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHTQVKELKPSKIKC
Protein: Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (O94302)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38206}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Replication termination factor 1
Sequence:
MDKSDSLLQSSSKGLRSSIFFQGSSRILTFFLNQLTIRLTSPSAYAFSSIHFEILQSTILFLSRESVRLAMQRIPSENAIITSTSTESNKSKKLSDQLQLIKNTSLISVYIGIVISLLVSLFYFYSLPNFPYSKTCIFIYTVSSFIELLSEPYYEVLQWRQKFSKTASAEGLGTIICSLLSFAISVLGRNKAPSSLPFALGNLSEKVTIFFTLRYFAKQPFSIFLHKVGENERYIFWDSSTLRIICSHTYQVLLKHLITKGDKIMVAWYASPSAQGPYALASNYGSLLARIVFRPVEDHSHIVFAQLTHYKNKKDEKKALNLLAWILKLYSYMSLFILFGSNYSDIVLLFGAGSKWASPDSSSILSWYAMYIPFMAANGVLEAFYVSAANSSQLYDQGKCYLASAVFYFITGKFLLSWFNLGSHGLILANILNLSLRICFALRFILHNYKDFSLPRSLPRPFLLALSILLSIISSFLVKHWRESKVPFLVYFLSAPSLAILYSCFIILVDKDVRGYAKILLSKYYIK
Protein: Tumor protein p53 binding protein 1 (F1M842)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine-protein kinase ATM
- Breast cancer type 1 susceptibility protein homolog
- X-ray repair cross-complementing protein 6
- PAX-interacting protein 1
- Mediator of DNA damage checkpoint protein 1
- DNA topoisomerase 2-binding protein 1
- CHK2 checkpoint homolog
- E3 ubiquitin-protein ligase RNF168
- Cellular tumor antigen p53
- Cellular tumor antigen p53
Sequence:
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSHFSVLSRHLPNLQMHKENPVLDIMSNPEQTVAEQGDSNSSFSEHLKEKKASDPVESSHLGTSGPISQVIERLPQPNRTSSALGVTVEAASLAEEEKEEELEEEKEEVGVNAPDADPRSLAEDSASSQLGFGVLELSQSQDVEEHTVPYDVKQEHLQLVTTNSGSTQLSDVDANTDGKAIKCEEQSTDAISIIEPSKDIPVTVQPSKGSHVVEEQNLPLVRSEDLPSSPQVSVAAVETKEQVPAQELLEGGLQVQVSSEPEVSSTQEDLFDQSSKTASDGCSTPSREEGGCSPVSTPATTLQLLQLSGQKPLVQESLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQGQRKDEPMDMSVIPEGGEHFQKLQDDEAVDIEKPLLPSQPAVSPQASTPVSRSTPVFTPASLPIPSQPEFSHDIFIPSPSLEEPSNDVEKGGGLHSSSLTVECSKTSESEPKNFTDDLGLSMTGDSCKLMLSTSECSQSSKMESLGSPRTEEVGENTQVEDTEPSSPVTKSKLPAESESVLVNPTQDDQVEMSQNVDKAKEDEVEDRGDVDVLAAGCKGREDMVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHPEEEFSGSEVEEVPETPCGSHREESKEEPMESIPLHLSLTETQSEALCLQKEAPKEECPEAMEVETSVISIDSPQKLPVLDQELEHKDPETWEEATSEDSSVVIVDVKEPSPRVDISCEPVEGVGKCSDSQSLEGAAPEEEPCAENRLNTPEEKRVECDGDSKAETTEKNSVTEDSPQPPLPSVRDEPVRPDQELQQPQVQEKESPVTLDAKVADDKHLGSEGSCQQLEKAPARASQSFCESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDVMSESMVEINDPLLGNEKGDSESAPEMDGKLSLKMKLVSPETEASEESLQFSLEKPTTAERRNGSTAIAEPVASPQKPMSVFGCIYEAQQEEEAQSGDPPSTPVRTNLLHFPSAQEEDREEPDATPQLRQSEQPVKLIGPVKDAAASEDSASSVSQQRASQGSLSPQEEVMEADLLEGLGANQDRPSKILMERPTQSNIGIQTMDHSLCAPETVSAATQTVKNVCEQGTSTVEQNSGKQDATVQTERGSGEKPASAPVDDTESLHSQGEEEFEMPQPPHGHVLHRHTRTIREVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSSHHTSSGTSLSAIHSSGSSGRGAGPLKGKTSGTEPADFALPSSRGGPGKLSPRKGISQTGAPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETVVSGPLGIEDTSPSMSPDDKSFTRIMPRVPDSTKRMDASSGALRRSDSPEIPFQAATGSSDGLDSSSSGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNISSPATPTASSSSSTTPTRKTTESPRASMGVPSGKRKLTTSEEERSPAKRGRKSATVKPGTVGAAELVSPCESGDNTGEPSVLEEPRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLLDGPTGSSEEEEEFLEIPPFNKQYTECQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFQQHPKYKHDYVSH
Protein: Probable fucosyltransferase 4 (AtFUT4) (EC 2.4.1.-) (Q9SJP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cell wall biosynthesis. May act as a fucosyltransferase.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Interaction partners:
- Beta-1,6-galactosyltransferase GALT31A
- Beta-glucuronosyltransferase GlcAT14A
- Beta-1,6-galactosyltransferase GALT29A
- Hydroxyproline O-galactosyltransferase GALT2
- Beta-arabinofuranosyltransferase RAY1
- Beta-1,3-galactosyltransferase 7
- Beta-glucuronosyltransferase GlcAT14B
- Beta-glucuronosyltransferase GlcAT14C
- Probable xyloglucan galactosyltransferase GT14
- Hydroxyproline O-galactosyltransferase GALT5
Sequence:
MYHIFQISGEVIKGLGLKTKILITIVFSTLLILSVMLLSFSNNFNNKLFAATINDESETPGRDRLIGGLLTADFDEGSCLSRYHKTFLYRKPSPYKPSEYLVSKLRSYEMLHKRCGPGTKAYKEATKHLSHDENYNASKSDGECRYVVWLADYGLGNRLLTLASVFLYALLTDRIILVDNRKDIGDLLCEPFPGTSWLLPLDFPLMKYADGYHKGYSRCYGTMLENHSINSTSFPPHLYMHNLHDSRDSDKMFFCQKDQSLIDKVPWLIFRANVYFVPSLWFNPTFQTELTKLFPQKETVFHHLGRYLFHPKNQVWDIVTKYYHDHLSKADERLGIQIRVFRDQGGYYQHVMDQVISCTQREKLLPELATQEESKVNISNIPKSKAVLVTSLSPEYSKKLENMFSERANMTGEIIKVYQPSGERYQQTDKKVHDQKALAEMYLLSLTDNIVASSRSTFGYVAYSLGGLKPWLLYLPNDNKAPDPPCVRSTSMEPCFLTPPTHGCEPDAWGTESGKVVPFVRYCEDIWGLKLFDEL
Protein: Pyroglutamyl-peptidase I (C15 family) (Q4Q301)
Organism: Leishmania major
Interaction partners:
Sequence:
MLHSKAGIVVFITGYGPFATVKVNPSSDIALRVAEGLKRHPDVAEVRYTELDVSVTSVAAYFEKVERDTADIIAEHGAGQVKILLCHLGVHNDTTGLICVEVQGCNELFSSVPDVDGKVLNHEPIVPEDGAIEVFHESWFGKEGSPQLEKLERLIQQVNDTVAESWHHWVTGAVTNNEVTSADTDRKDMAMPTFQAPSSAISRNAGRYLCNCALYHALRLQEKNPGVVYGIFVHVVDPIRGKTEIEGGPIVAYNPPTIVQSVQVQCLMHGLLSLMTM
Protein: Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) (Q9L9I7)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Interaction partners:
- 2-iminoacetate synthase
- Thiamine-phosphate synthase
- Thiazole synthase
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
- 84% identity over 251 amino acids with E. coli THIF protein
- STMF1.36 protein
- Hydroxyethylthiazole kinase
- Phosphoribosylformylglycinamidine cyclo-ligase
- N5-carboxyaminoimidazole ribonucleotide synthase
- Biotin synthase
Sequence:
MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPYGDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTPEMEFIAIRENMGRERIRSEVLRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQTIEIGMADMSEDFRAKGGEIYLKREEA
Protein: F-box protein PP2-A11 (Protein PHLOEM PROTEIN 2-LIKE A11) (AtPP2-A11) (SKP1-interacting partner 10) (Q9CAN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Immune-associated nucleotide-binding protein 10
- SH2 domain-containing protein B
- Protein PHLOEM PROTEIN 2-LIKE A5
- Protein PHLOEM PROTEIN 2-LIKE A2
Sequence:
MGSGFSLFQKNLSSCYGDRDLLQPGLGDLPESCVALILQNLDPVEICRFSKLNTAFHGASWADFVWESKLPPDYKLILEKILGSFPDNLRKRDIFTFLSRVNSFDEGNKKAWVDKRTGGLCLCTSAKGLSITGIDDRRYWSHIPSDDSRFASVAYVQQIWWFQVDGEIDFPFPAGTYSVYFRLQLGKPGKRFGWKVVDTEQVHGWNIKPVRFQLSTEDGQHSSSQCMLTEAGNWSHYHAGDFVVGKSKSSSTKIKFSMTQIDCTHTKGGLCVDSVVVYPSSCKDRLMQI
Protein: Cilia- and flagella-associated protein 206 (Q38A96)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKAAQPVVVDVEETFDSVAEKLWCALPSVAKFHATFEKTPILGAESGNVGVVPQQSSVEDTSEAAAAKLDPPVTIRDAVVPVDEMQHLAGCVYTACHTNPVDADVEAAVAAILDKGDEENSVEYSWGDFREFLERVESQWMEWADMDQKWLAVTERQHIQVLKDLLESITYDVEPFGLLPRDKVLTMRSTIVHTKQLRTLFKTFVDFVSPPEYPAVYDKLWGLLIASQNGCEVAEVSPETPLELNSFTKFVLWFCLSIFVNATEAGLVVAAKTLWLRHLNERGVMLKKQFVDVCRYMCKFYSVGGSDVEYFEKCCARSEEALQGSDELPPFALFQQYMQPTEGRMLVDPNDLYIPEELERSKWMEELYRMNCSSNRIIVHGRRGVGKSHLAASLAKRLGCVHLDAGELALEAEAAAPADPLGAQLRECTDADAPISLATLAALVRKKICSSETRYRGYVFSDIPFFSSENDAEKISFFTDCGLLDELVPTTFVLVDCENEFHPERLEATLAARESDHQEELSLLKEEKEEEASYEALAQKIEELKATLSQITTKQEVEGGAEAPEGEEANAPELDPEEVEKDLKQLLEDQTVQEERKIEQADSRIARTKKYRELRLRRLVAQTLSEGYESGNEMSLTALPCFETALCRARLMGRCLTVDCASVAEEAVTYIVDTLSLQPCVRPWALVDKVERDPEREGSVFDDPDIERLTEEFATNFGVMTSSRWKRFCPVTFAEHGVLVEGSIAFGCVFRQQLFYLASEEKLSMFRANPCLYLGTLPLSREPILLLSLVEPQNDAQLSPTDMQILVRKLHEQLDLTPMAFSEFTTLWDSHRLLKGKRAEVLSNRTKYEVVERKQRADRLKKRLAQEKRKKKSQKSPGKGKGKKAKSVVEEVTVEEYKGWEKKAEAPETIATRIAKNLEERLERQNTLVPVLVHALDDNPLSGFDQLFSEKVVPRTVVVLQYEKPTKAEDSAVLEPSAAEGVEENSGEVPKVLLPQEVVLDKLSDLPDGGVDIVAEVSPHDVAIHRIVVNDKDVHALVTEIMQAVCPGMDPVGVGVVDDAVGEDDEEDAQEFDDDENEEDDVPTAVNPAIKPGKTFLNQFGTTLEFCPVTLCERRLLVRGQSDHCLQYRGYVYTFASLEAKTKFEFNPLRYMRSSYSLPPCRMWIVGQSKSGKKTLAQSLHEAYDVPYFQYNRKLFDQCVEVAMTPTGGVISNIFIPPQTFDNPYLALAAGILKEVQEFDPEQERRMKLREEAERELERREEAANNGDEEEDELDEEAEARLQEHLAFEPETEHDRQLRLSEAYLKVAGCVTHIEPFASKGYIMVCPPFSDGDIEVLSSVDAIPEVTVNMEVSDEIYIKRNKEAMSSVSYSEMSSGGIPEVREEPVVNEEAKLLRRLEYEDRRKEREVARWRRRHIGADDPESDIDEELGDEGAAGGGNDESQEDEANERPFDQDLIVEKEAVGEFAEAVEERSIPMIVLNGDLSRNAVFRRAVRRLSRFLENRRSLLHAPQIVRYEDATRMLESGEATLSCFGSTDPVTLYDLRHGSRRVCKWRPDGAYLEEEPLIEPDSSSSDAQGTAVPEGSEGKDESEDTLDSGDRKPEPPQLDTSSTEGDTESGDDEEMSELDSELLDEITEKFANRRRREWLRTCQRVALLHGRLFFFESDETLLRYMQNPLLFIQQPPPQPPLRSMPVITFYDDDGAYPPENSGPSRKRCTAEHVAFNLNWIYLSLPKLLSWSAVNASLLSLSRKAIDAVLSGSVDDALVARLLGHRLNAADAKQNGVVLHNLPRTPDQYRLLLAWGLKVDKIFQFDDNYRDVATLMKSTATIEKQLTTARVSVAGLSEICDCIDGFVVNEGRAILSHLTGFPIDIDNSYHTVADIETHLSPYRWFCPYSWCLGENLVDQEKADCRFAALYDGQYYFFSSEEYLERFLLCPSQVTLPPGFKALPTPLPVRVQPSTEYAFELEGCCPVLLYDTRENRGLRGVLEPVARKGNPSCIVEYGGCYYALLDEEAVRRFLMRPWQYVDGAKLPPSRKVPLPEGKTMSTIDEEEFIRRILYDPVAHALIAVAEVRPKYYGLSLEESALKYIALHMKCFNPKNSEIQAKQYKKKFEIFSKQSTLYKTITMHSNSITQNEKFAELCDEWENSKYGREKELSIHCGCETEPV
Protein: Squamosa promoter-binding-like protein 9 (Q700W2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular location: Nucleus {ECO:0000269|PubMed:16095614}. Cytoplasm {ECO:0000269|PubMed:16095614}. Note=Mostly located in nucleus.
Interaction partners:
- Transcription factor TCP4
- AP2-like ethylene-responsive transcription factor TOE2
- DELLA protein RGA
- MADS-box protein SOC1
- Ethylene-responsive transcription factor RAP2-7
- AP2-like ethylene-responsive transcription factor SNZ
- AP2-like ethylene-responsive transcription factor TOE3
- Agamous-like MADS-box protein AGL8
- AP2-like ethylene-responsive transcription factor SMZ
- MYB-like transcription factor TCL1
Sequence:
MEMGSNSGPGHGPGQAESGGSSTESSSFSGGLMFGQKIYFEDGGGGSGSSSSGGRSNRRVRGGGSGQSGQIPRCQVEGCGMDLTNAKGYYSRHRVCGVHSKTPKVTVAGIEQRFCQQCSRFHQLPEFDLEKRSCRRRLAGHNERRRKPQPASLSVLASRYGRIAPSLYENGDAGMNGSFLGNQEIGWPSSRTLDTRVMRRPVSSPSWQINPMNVFSQGSVGGGGTSFSSPEIMDTKLESYKGIGDSNCALSLLSNPHQPHDNNNNNNNNNNNNNNTWRASSGFGPMTVTMAQPPPAPSQHQYLNPPWVFKDNDNDMSPVLNLGRYTEPDNCQISSGTAMGEFELSDHHHQSRRQYMEDENTRAYDSSSHHTNWSL
Protein: Potassium channel subfamily K member 17 (Potassium channel, subfamily K, member 17) (A0A140LFQ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- GTP-binding protein REM 2
Sequence:
MLSMFSGRLCQFLSVTRLPSILFLGVFYVAYVLVGGLVFWKLEGWYVLQQIALLKEKRLELLEKYPCLGQNGLSELAQMIKSASLSGLSPDSNDTADGLWKFTSSSVFAATVVTTIGYGNIVPLTTAGQIFCVMFALFGIPLNVVVLNRVGKYMLAIERHFCNFLEKKIDRGKCVRISIHSISFVSSAFLYLVVPMLLFKEYEGWSYAEAIYYCFITLSTIGFGDYVADHNPEINYPEWYSCLMAVWIFFGLAWLALLVNHTIDLLESLNAYLRGRQTGQSQTNETEEKPEKGLKEEET
Protein: Cell division control protein 45 homolog (Suppressor of nda4 protein) (O74113)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4.
Subcellular location: Nucleus {ECO:0000269|PubMed:9619628}.
Interaction partners:
- S-M checkpoint control protein rad4
- DNA replication licensing factor mcm5
- DNA replication licensing factor mcm7
- DNA replication licensing factor mcm4
- DNA polymerase epsilon subunit B
- DNA replication complex GINS protein psf1
- DNA replication complex GINS protein psf3
- DNA replication licensing factor mcm3
- DNA replication licensing factor mcm6
- DNA replication licensing factor mcm2
Sequence:
MFIKRSDYASAYLKIKEASVSGGCTVQLFVALDPDALCACKLLSTLLKGDFISHKIRPVSGYRDLEQANKTLLEQNEDIKFIILLNCGTMVDLNNYLVSMEDVSIYVIDSHRPHNLNNIYIENNIFVFDDGDIEEDMNKIHDAWYAFNSHELSDEENSDSSNEREEEVEDDNRSVESYSSSDYQARSRRRFSEETTQRRAEIKEKRKKRKEFASILSEYYEKGSWYGESITNILFAVASMLGREDNDMLWLAIVGLTCLEIHCQSSKKYFNRSYSLLKDEVNRLNPSPLENQIVGRAHGKTPHDQSIRLEDEFRFMLVRHWSLYDSMLHSAYVGSRLHIWSEEGRKRLHKLLAKMGLSLVECKQTYIHMNMDLKKTLKSSLKRFAPFYGLDDVIFHSFTRTYGFKCTLSASDVSYAISALLEMGNTGVLLQSKTVARSPDMTEEEYLEKFENAQNQEWLHNFYDAYDALDDVDSLERALKLAMHLQRAIVRTGITLLEKRAIKTLRSFRFGLINEGPDLKIFMHPLALTKMSLWIAEAINEQEREFGKLRHLPLVLAAFVEEKNRYLIVGTSTSAFTSNEDDDDDDGHGHNRFGVAFQEVANMTSATLQMDCFEASVIECQKSDLGVFLESLSFKTLL
Protein: Glypican-3 (Intestinal protein OCI-5) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] (P13265)
Organism: Rattus norvegicus (Rat)
Function: Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7487896}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:7487896}; Extracellular side {ECO:0000269|PubMed:7487896}.
Interaction partners:
- Protein Wnt
- Netrin receptor UNC5D
- Insulin-like growth factor 2
- Protein Wnt
- Protein Wnt-5a
- Sonic hedgehog protein
- Hedgehog protein
- Protein Wnt-4
- Protein Wnt
- Protein Wnt
Sequence:
MAGTVRTACLLVAMLLGLGCLGQAQPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQMMNPGLPESVLDINECLRGARRDLKVFGSFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNGGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVARVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSVPKGKVVDKSLDEEGLESGDCGDDEDECIGSSGDGMMKVKNQLRFLAELAYDLDVDDAPGNKQHGNQKDNEITTSHSVGNMPSPLKILISVAIYVACFFSWCTDLPCPCLCCPAAPCGPPT
Protein: Vitamin D3 receptor (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) (F1D8P8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
Protein: Chondroadherin (Cartilage leucine-rich protein) (O70210)
Organism: Rattus norvegicus (Rat)
Function: Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Integrin alpha-2
- Integrin beta-1
- Amelogenin, X isoform
- Integrin alpha-11
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L1
- Integrin beta-6
- Chymotrypsin like elastase 3B
- Integrin subunit alpha 10
Sequence:
MARVLLLSLVFLAILLPALAACPQNCHCHGDLQHVICDKVGLQKIPKVSETTKLLNLQRNNFPVLAANSFRTVPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALTSLHPGSLDDVENLAKFHLDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDAAFAGVTTLKHVHLENNRLNQLPSTFPFDNLETLTLTNNPWKCTCQLRGLRRWLEAKTSRPDATCSSPAKFKGQRIRDTDALRSCKSPTKRSKKAGRH
Protein: Tachykinin-related peptide 3 (TKRP-3) (P86589)
Organism: Pentatoma rufipes (Forest bug) (Cimex rufipes)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
GPSSGFFGMR
Protein: Protein BEX4 (Brain-expressed X-linked protein 4) (Q3MKP9)
Organism: Rattus norvegicus (Rat)
Function: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability.
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9NWD9}. Nucleus {ECO:0000269|PubMed:15958283}. Cytoplasm {ECO:0000269|PubMed:15958283}. Note=Also localizes to microtubules. {ECO:0000250|UniProtKB:Q9NWD9}.
Interaction partners:
- RBPJ-interacting and tubulin-associated protein 1
Sequence:
MASKVKQVILDLTVEKDKKNKKGGKASKQSEEESHHLEEVENKKPGGNVRRKVRRLVPNFLWAIPNRHVDHSEGGEEVGRFVGQVMEAKRKSKEQQMRPYTRFRTPEPDNHYDFCLIP