wanglab/gogpt-training-data huggingface dataset:
Protein: Acetamidase/Formamidase family protein (Putative formamidase) (Q8H1G4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nitrilase 2
- Glutamine synthetase cytosolic isozyme 1-5
- Glutamine synthetase cytosolic isozyme 1-3
- Glutamine synthetase cytosolic isozyme 1-2
- Glutamine synthetase, chloroplastic/mitochondrial
- Nitrilase 1
- Glutamine synthetase cytosolic isozyme 1-4
- Glutamine synthetase cytosolic isozyme 1-1
- Ferredoxin--nitrite reductase, chloroplastic
- Nitrilase 3
Sequence:
MAPASPRVVVKVDLKKRPWQQTQPLHNRWHPEIPSVAEVKTGELFRVEMVDWTGGAVKEDGSAGDIKSIDLSTVHYLSGPIKVVDEDGVAARPGDLLAVEICNLGPLPGDEWGFTASFDRENGGGFLTDHFPCATKAIWYFEGIYAYSPQIPGVRFPGLTHPGIIGTAPSKELLRIWNERERQLEEKGVESLTLCEVVHQRPLASLPTTKGCLLGNIEERTSEWERIAKEAARTIPGRENGGNCDIKNLSSGSKIYLPVFVEGANLSTGDMHFSQGDGEISFCGAIEMSGFLELKCEIIRNGMQEYLTPMGPTTLHVNPIFEIGPVEPRFSEWLVFEGISVDESGRQHYLDATVAYKRAVLNAIDYLFKFGYSKEQVYLLLSCCPCEGRISGIVDSPNAVATLAIPTAIFDQDIRPKTRKVPTGARIVKKPDVMKSTYDGKLPITKNSSSSS
Protein: RNA-binding protein Musashi homolog 1 (Musashi-1) (O43347)
Organism: Homo sapiens (Human)
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q61474}. Nucleus {ECO:0000250|UniProtKB:Q61474}.
Interaction partners:
- RNA-binding protein Musashi homolog 2
- DAZ-associated protein 1
- Zinc finger CCCH domain-containing protein 14
- Roundabout homolog 3
- Transcription factor SOX-2
- Numb-like protein
- Protein numb homolog
- Nestin
- Cytoplasmic polyadenylation element-binding protein 1
- La-related protein 1
Sequence:
METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH
Protein: Putative uncharacterized protein YPR146C (O13571)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Putative uncharacterized protein YGR122C-A
Sequence:
MQNMLSMHFFSVMASLNAMASMRVIVFLYQLSILGDCSTIDSLRDLMISQIVLAYNCISVHVNMYISTNGSEASIASRMSTLESCLFLITMNKGSASFGKRRFFYRDLA
Protein: Protein OPG068 (Protein E6) (P21607)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Plays an essential role for maintaining proper localization of the seven-protein complex and the viroplasm during assembly.
Subcellular location: Virion {ECO:0000269|PubMed:20116821}. Host cytoplasm {ECO:0000305}. Note=Localizes in viroplasm and in the mature virion (MV). {ECO:0000269|PubMed:20116821}.
Interaction partners:
Sequence:
MDFIRRKYLIYTVENNIDFLKDDTLSKVNNFTLNHVLALKYLVSNFPQHVITKDVLANTNFFVFIHMVRCCKVYEAVLRHAFDAPTLYVKALTKNYLSFSNTIQSYKETVHKLTQDEKFLEVAKYMDELGELIGVNYDLVLNPLFHGGEPIKDMEIIFLKLFKKTDFKVVKKLSVIRLLIWAYLSKKDTGIEFADNDRQDIYTLFQQTGRIVHSNLTETFRDYIFPGDKTSYWVWLNESIANDADIVLNRHAITMYDKILSYIYSEIKQGRVNKNMLKLVYIFEPEKDIRELLLEIIYDIPGDILSIIDAKNDDWKKYFISFYKANFINGNTFISDRTFNEDLFRVVVQIDPEYFDNERIMSLFSTSAADIKRFDELDINNSYISNIIYEVNDITLDTMDDMKKCQIFNEDTSYYVKEYNTYLFLHESDPMVIENGILKKLSSIKSKSRRLNLFSKNILKYYLDGQLARLGLVLDDYKGDLLVKMINHLKSVEDVSAFVRFSTDKNPSILPSLIKTILASYNISIIVLFQRFLRDNLYHVEEFLDKSIHLTKTDKKYILQLIRHGRS
Protein: Uncharacterized protein YOL098C (Q12496)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YMR074C
- Uncharacterized protein YEL057C
- Putative glutamine amidotransferase YLR126C
- Large ribosomal subunit protein uL14A
- Uncharacterized peptidase YFR006W
- Zinc finger protein YPR022C
Sequence:
MGFKKLVSFQPDYVPQYHITKYISERTKLQLVHINHKTSPLVHGYFAVPTECLNDSGAPHTLEHLIFMGSKSYPYKGLLDTAGNLSLSNTNAWTDTDQTVYTLSSAGWKGFSKLLPAYLDHILHPTLTDEACLTEVYHIDPENLGDKGVVFSEMEAIETQGWYISGLEKQRLMFPEGSGYRSETGGLTKNLRTLTNDEIRQFHKSLYSSDNLCVIVCGNVPTDELLTVMEEWDNKLPEIPSNIPKKRPFLDNKLSHIPQSRDKVTESTVEFPELDESQGELLFSWIGVPYSDFRNDLAVDVLLDYFTDSALAVFTRELVEIDDPMANSTDCCTDYFMRTIIDLRIQGVPTEKIAATKTKVLEILKTHTIDLSRVRQVVENTKWEYLLNYEKNGESRFSSAVITDYIYGNEDGSSLVSSLKDLSDFDALLQWSQKDWQSLLNRIFVDNKPIIVTAKPSALMYEQLEKEKSDLIKQREAEFDDEKKLVLLKRLNNAKNINDRPIPKSLLQKFEIDNPSKSVEFVNTKSIATVDSYKYNNVSDPLTKKILETRPDNFPLFIHLNHFPSQFIELHFLVNSASIKDTSLLPYFNMFDELFSMPMKILDEESNVETMLSFEEVVAKLKSETIDAQINQGLKGSCPDLINFKIQCRAGGYSNSVQWIKHCLFDMVFDENRVRILLENYLNSIVEWKRNGNVMLSSLTNRNLYSARSLKKSTDPLFVEAKLQEIFAEIENGNFEKEILPRIETMRKQLRANFNKFHILVLGDISKIDDVYEPWNPLIKCLNIAHPVEKLKIPPVPRALDTISSICRTPGEKAFIITTPASESAYMNLITSIPFNLDYHDPEYAIVSLASEYLECVEGPFWKGIRGAGLAYGASMLKLCEINSWGFNIYRGADIIKCYEVGKQIVQDYASGALEFDEQLIQGAISSIINRLATIECGYFETALSKYVDEFCLQRGNNFNELYLERLQNVTKTDLKNAMQKYFVNMFDSNKSVAFVSCHPAKLESVQEFFETQGFTVEIEELEDDDDEIDSEEDENA
Protein: AT13367p (Q8IHD1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVTRSAATKKQNQVLTLSDQNILAESSRTKGPPVPKKNVKKLPTARQCVKVAANLLDAQEPNENENTGTQRKDGKQLQAQNSNENEKTSTLKKDKKLLASKTPEAATNDNANPNMKPSLKKSTREHKSKKCNDIQKAGKDHIEHQAE
Protein: Delta-1 crystallin (Delta crystallin I) (P02521)
Organism: Gallus gallus (Chicken)
Function: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles.
Interaction partners:
- Argininosuccinate synthase
- Ornithine aminotransferase
- Ornithine transcarbamylase, mitochondrial
- Mitochondrial tRNA-specific 2-thiouridylase 1
- Delta-1-pyrroline-5-carboxylate synthase
- Arginase
Sequence:
MATEGDKLLGGRFVGSTDPIMEILSSSISTEQRLTEVDIQASMAYAKALEKASILTKTELEKILSGLEKISEESSKGVLVMTQSDEDIQTAIERRLKELIGDIAGKLQTGRSRNEQVVTDLKLLLKSSISVISTHLLQLIKTLVERAAIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPLGSGALAGNPLEIDRELLRSELDMTSITLNSIDAISERDFVVELISVATLLMIHLSKLAEDLIIFSTTEFGFVTLSDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGIPSTFSKDLQEDKEAVLDVVDTLTAVLQVATGVISTLQVNKENMEKALTPELLSTDLALYLVRKGMPIRQAQTASGKAVHLAETKGITINNLTLEDLKSISPLFASDVSQVFSVVNSVEQYTAVGGTAKSSVTAQIEQLRELLKKQKEQA
Protein: Serine/threonine-protein kinase pim-1 (EC 2.7.11.1) (P11309)
Organism: Homo sapiens (Human)
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells. Promotes brown adipocyte differentiation (By similarity).
Subcellular location: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane.
Interaction partners:
- Serine/threonine-protein kinase pim-2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Alpha-1-antitrypsin
- Probable ATP-dependent RNA helicase DDX6
- mRNA-decapping enzyme 1A
- Enhancer of mRNA-decapping protein 3
- mRNA-decapping enzyme 1B
- Signal transducer and activator of transcription 5A
- Signal transducer and activator of transcription 5B
- Myc proto-oncogene protein
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Protein: Proline dehydrogenase (PRODH) (EC 1.5.5.2) (DrPRODH) (Proline oxidase) (Q9RW55)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Function: Converts proline to delta-1-pyrroline-5-carboxylate.
Interaction partners:
- L-glutamate gamma-semialdehyde dehydrogenase
- L-glutamate gamma-semialdehyde dehydrogenase
- Pyrroline-5-carboxylate reductase
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase
- aldehyde dehydrogenase
- Succinate-semialdehyde dehydrogenase [NADP
- Succinate-semialdehyde dehydrogenase
- Transcriptional regulator, GntR family
- Fluoride-specific ion channel FluC
Sequence:
MIDQLYRKAVLTVAERPQVEQLARQKMWNLAERFVAGESIESAIQAVQALERDGIAGNLDLLGEFIDSPAKCTEFADDVIKLIEAAHAAGIKPYVSIKLSSVGQGKDENGEDLGLTNARRIIAKAKEYGGFICLDMEDHTRVDVTLEQFRTLVGEFGAEHVGTVLQSYLYRSLGDRASLDDLRPNIRMVKGAYLEPATVAYPDKADVDQNYRRLVFQHLKAGNYTNVATHDERIIDDVKRFVLAHGIGKDAFEFQMLYGIRRDLQKQLAAEGYRVRVYLPYGRDWYAYFSRRIAETPRNAAFVVQGMLKG
Protein: Tabersonine 16-O-methyltransferase (EC 2.1.1.94) (B0EXJ8)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: 16-O-methyltransferase involved in the biosynthesis of vindoline. Highly specific for 16-hydroxytabersonine. No activity with tabersonine, 3-hydroxytyramine, 4-hydroxytyramine, 5-hydroxytryptamine (5HT), 2,3-dihydro-3-hydroxytabersonine, lochnericine, hoerhammericine, 16-hydroxy-2,3-dihydro-3-hydroxytabersonine, 16-hydroxylochnericine, 16-hydroxyhoerhammericine, quercetin, kaempferol and caffeic acid as substrates.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21047699}.
Interaction partners:
Sequence:
MDVQSEEFRGAQAQIWSQSCSFITSASLKCAVKLGIPDTIDNHGKPITLSELTNALVPPVHPSKAPFIYRLMRVLAKNGFCSEEQLDGETEPLYSLTPSSRILLKKEPLNLRGIVLTMADPVQLKAWESLSDWYQNEDDSSTAFETAHGKNFWGYSSEHMEHAEFFNEAMASDSQLISKLLIGEYKFLFEGLASLVDIGGGTGTIAKAIAKNFPQLKCTVFDLPHVVANLESKENVEFVAGDMFEKIPSANAIFLKWILHDWNDEDCVKILKSCKKAIPAKGGKVIIIDMVMYSDKKDDHLVKTQTSMDMAMLVNFAAKERCEKEWAFLFKEAGFSDYKIYPKLDFTRSLIEVYP
Protein: Caspase-3 (EC 3.4.22.56) (O93417)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- E3 ubiquitin-protein ligase XIAP
- Actin, cytoplasmic 1
- Cytochrome c
- Apoptosis regulator Bcl-2
- Caspase 9
- Poly [ADP-ribose] polymerase 1
- Apoptotic protease-activating factor 1
- Inhibitor of apoptosis protein
- Bcl-2-like protein 1
- Caspase-8
Sequence:
MMTDIKDGPRSGEDVSDARSFPGSKGMNLPASKSVDSGILPDDSYRMDYPEIGVCVIINNKNFHRDTGLSSRSGTDADAASVREVFMKLGYKVKLNNDLSSRDIFKLLKNVSEEDHSKRSSFVCVLLSHGDEGLFYGTDGPLELKVLTSLFRGDKCRSLAGKPKLFFIQACRGTELDSGIEADSGPDETVCQKIPVEADFLYAYSTAPGYYSWRNAAEGSWFIQSLCRMLKEHARKLELMQILTRVNRRVAEYESCSTRQDFNAKKQIPCIVSMLTKEFYFPC
Protein: ATP synthase subunit b (Q5QNZ2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|RuleBase:RU368017}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU368017}.
Interaction partners:
Sequence:
MLSRVVLSAAATAGPYVLGTGLILYALSKEIYVISAETFTALSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALVQKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINWVEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM
Protein: 3'(2'),5'-bisphosphate nucleotidase (EC 3.1.3.7) (Q57YS3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Inositol-1-monophosphatase
- Phosphoinositide phospholipase C
- inositol-polyphosphate 5-phosphatase
- Phosphatidate cytidylyltransferase
- Phosphatidylinositol 4-phosphate 5-kinase alpha, putative
- Synaptojanin
Sequence:
MPQVDLVKLLQICVNGALAAQQYILLDLIQLRSLEVSRRDVCIADLDQQEIARLRARLKAAVSVDVKGKLEYKEGGSVDDLVTTADVVTQGLMERLLAEAFPDTPFTIIGEEEATTTDAIKIQVERCVEAFRDVNAVAPLQKELEAHASSDSRHVSASTVEELRARVGVFIDPIDATSCFVDGTWGAPMTLVGITVDGVPVAGVSNRFFYSTVDDLTSGGNAGCTGLSYVWNDPSAGPFIVHEGRLATPLWSLGRKTTSNLAMLRVIRSGTTSNKRFEQLLARLQPVEPRSARGAGNKLMLLVVSMLAASDGAAAAACDVFLAPPNSISKWDTCAAHAFLLALGGDMRTLRGELIRYPLRGTTNLKTLPDGVVGLTRWSMTEGLRRLGWQ
Protein: Endoplasmic reticulum to nucleus signaling 1 (A0A8I6A2F5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPARWLLLLLALLLLPPGPGSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTVGSPGPRRQKERTDSSKLFSGLHTCAAPCIQSPSQHTEINKCHKKFFKKSLHPSHIREICFSFRESMW
Protein: Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) (Q9H4B6)
Organism: Homo sapiens (Human)
Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19212654}. Cytoplasm {ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:29063833}.
Interaction partners:
- Serine/threonine-protein kinase 3
- Serine/threonine-protein kinase LATS1
- Serine/threonine-protein kinase 4
- Serine/threonine-protein kinase LATS2
- FAD-linked sulfhydryl oxidase ALR
- Wilms tumor protein 1-interacting protein
- Ras association domain-containing protein 1
- MOB kinase activator 1A
- LIM domain-containing protein 1
- LIM domain-containing protein ajuba
Sequence:
MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF
Protein: CDKN2A-interacting protein (Collaborator of ARF) (Q9NXV6)
Organism: Homo sapiens (Human)
Function: Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:12154087, ECO:0000269|PubMed:12581788}.
Interaction partners:
- Cyclin-dependent kinase inhibitor 2A
- 5'-3' exoribonuclease 2
Sequence:
MAQEVSEYLSQNPRVAAWVEALRCDGETDKHWRHRRDFLLRNAGDLAPAGGAASASTDEAADAESGTRNRQLQQLISFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPTYTTRDELVAKVKKRGISSSNEGVEEPSKKRVIEGKNSSAVEQDHAKTSAKTERASAQQENSSTCIGSAIKSESGNSARSSGISSQNSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKHGSASFVSLLKSSVNSHMTQSTDSRQQSGSPKKSALEGSSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSETASSGLTSKTSSEASVSSSVAKNSSSSGTSLLTPKSSSSTNTSLLTSKSTSQVAASLLASKSSSQTSGSLVSKSTSLASVSQLASKSSSQTSTSQLPSKSTSQSSESSVKFSCKLTNEDVKQKQPFFNRLYKTVAWKLVAVGGFSPNVNHGELLNAAIEALKATLDVFFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKVVVKICKRKYRGSEIEDLVLLDEESRPVNLPPALKHPQELL
Protein: Carnosine dipeptidase 2 (A0A087WYZ1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQVCPPR
Protein: Baseplate tail-tube junction protein gp54 (Gene product 54) (gp54) (P13341)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Baseplate protein that forms, together with gp48, the baseplate-tail tube junction. The tail tube first 2 annuli are formed by gp48 and gp54, which are in continuation of the spike complex. Involved in the tail assembly. Morphogenesis of the baseplate is completed by association of gp48 and gp54, which bind the upper part of the baseplate dome to form the platform for polymerization of the tail tube.
Subcellular location: Virion {ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:2403438, ECO:0000269|PubMed:27193680}. Note=Present in 6 copies in the baseplate. {ECO:0000303|PubMed:21129200}.
Interaction partners:
Sequence:
MYSLEEFNNQAINADFQRNNMFSCVFATTPSTKSSSLISSISNFSYNNLGLNSDWLGLTQGDINQGITTLITAGTQKLIRKSGVSKYLIGAMSQRTVQSLLGSFTVGTYLIDFFNMAYNSSGLMIYSVKMPENRLSYETDWNYNSPNIRITGRELDPLVISFRMDSEACNYRAMQDWVNSVQDPVTGLRALPQDVEADIQVNLHSRNGLPHTAVMFTMHSISVSAPELSYDGDNQITTFDVTFAYRVMQAGAVDRQRALEWLESAAINGIQSVLGNSGGVTGLSNSLSRLSRLGGTAGSISNINTMTGIVNSQSKILGAI
Protein: Rop guanine nucleotide exchange factor 7 (AtRopGEF7) (Rho of plants guanine nucleotide exchange factor 7) (Q9LZN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. In postembryonic roots, modulates root stem cell maintenance by regulating the expression of PLT1 and PLT2, which are key transcription factors that mediate the patterning of the root stem cell niche. May connect RopGEF-regulated Rac/Rop signaling and auxin-dependent PLT-regulated root pattern formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22984069}. Cell membrane {ECO:0000269|PubMed:22984069}. Note=Interacts with ARAC1/ROP3 on plasma membrane.
Interaction partners:
- Rac-like GTP-binding protein ARAC1
- Rac-like GTP-binding protein ARAC10
- Stress up-regulated Nod 19 protein
- Pollen receptor-like kinase 2
Sequence:
MDGSSENLPEVEEKGRESSCCSSETTRQEEEEQSPSCTEDFTASPVSSRWSVKNIDGEKKKIRSDSRVSEVEMMKERFSKLLLGEDMSGSGNGVCTALAISNAITNLCATLFGQLWRLEPLPTEKKEMWRREMEWLLCVSDHIVEMTPTWQTFPDGTKLEIMTCRPRSDLYVNLPALRKLDNMLLEILDSFEETEFWYVDQGIMAHESAADGSSSFRKSFQRQEDKWWLPVPRVSPGGLQENSRKQLQHKRDCTNQILKAAMAINSITLADMEIPESYLESLPRKGRSCLGDLIYRYISSDQFSPECLLDCLDLSSEHQAIEIANRVESSIYLWHKRTNSKPATNTKTSWEMVKELMVDADKLELMADRAESLLLSLKQRFPGLPQTALDMSKIQYNKDIGKSILESYSRVLESLAFNIVARIDDLLFVDDLTRHSSDQIPTTLGNNGNDAPKSIAVPVSNYTTPSYSPSKQELRSSITVPPSPSRFKIPHSSSVKRVLTAYVTKNEPRLKNLPLERSSRSSSSERLSLEKCMKESLNVSNLDPGI
Protein: Pyruvate decarboxylase (G8BHF2)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Fructose-bisphosphate aldolase
- Phosphoglycerate kinase
- Pyruvate kinase
- Transketolase
- Glucose-6-phosphate isomerase
- Transaldolase
- Aldehyde dehydrogenase domain-containing protein
- Pyruvate dehydrogenase E1 component subunit alpha
- Glucose-6-phosphate 1-dehydrogenase
- phosphopyruvate hydratase
Sequence:
MSEITLGRYLFERLHQLKVDTIFGVPGDFNLSLLDKIYEIDGMRWAGNANELNAGYAADGYSRVKGMGAIVSTFGVGELSLTNAIAGSFAEHCAILNVVGVPSVNAQAKQLLLHHTLGNGDFTVFHRMFKNISHSSAFISDINSAPNEIDRCIRDAYVYQRPVYVGLPSNLVDLMVPSSLLETPIDLSLKPNDQDAQEEVIETVERLIKEAKNPVILVDACASRHSCKPEVAQLVDATQFPVFTTPMGKSGINESHPRFGGVYVGSLSRPDVKEAVESADLILSIGALLSDFNTGSFSYAYKTKNVVEFHSDYTKIRQATFPGVQMKEALQKLLETVTSSVNPSYTPSPVPQQKLINSPAPPNTPLTQEYLWTKVSSWFREGDIIVTETGTSAFGIVQSRFPNNTIGISQVLWGSIGYTVGATCGAAMAGQEIDPNRRVILFVGDGSLQLTVQEISTMCRWNCNNTYLFVLNNDGYTIERLIHGENATYNDIQPWNNLQLLPLFNAKDYETKKVSTVGELNDLFQDKAFAKPDKIRMVEVMLARMDAPANLVAQAKLSEKTNAEPN
Protein: Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (mEK4) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (P29319)
Organism: Mus musculus (Mouse)
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Subcellular location: [Isoform Long]: Cell membrane {ECO:0000250|UniProtKB:P29320}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted {ECO:0000250|UniProtKB:P29320}.
Interaction partners:
- Ephrin-A5
- Ephrin-A2
- Ephrin-A1
- Ephrin-A3
- Ephrin-B2
- Tyrosine-protein kinase ABL1
- Ephrin-A4
- Ephexin-1
- Ras GTPase-activating protein 1
- Ephrin-B3
Sequence:
MDCHLSILVLLGCCVLSCSGELSPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCTCNAGYEERGFICQACRPGFYKASDGAAKCAKCPPHSSTQEDGSMNCRCENNYFRAEKDPPSMACARPPSAPRNVISNINETSVILDWSWPLDTGGRKDITFNIICKKCGWNVRQCEPCSPNVRFLPRQLGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQYAAVSITTNQAAPSPVMTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYQKQEQETSYTILRARGTNVTISSLKPDTTYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGRFCGYHKSKHSAEEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAMSYRKFTSASDVWSYGIVLWEVMSYGERPYSQMSNQDVIKAVDERYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIATFHTTGDWLNGMRTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISTIKALETQSKNGPVPV
Protein: Triosephosphate isomerase (PfTIM) (EC 5.3.1.1) (Triose-phosphate isomerase) (Q07412)
Organism: Plasmodium falciparum
Function: Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.
Interaction partners:
Sequence:
MARKYFVAANWKCNGTLESIKSLTNSFNNLDFDPSKLDVVVFPVSVHYDHTRKLLQSKFSTGIQNVSKFGNGSYTGEVSAEIAKDLNIEYVIIGHFERRKYFHETDEDVREKLQASLKNNLKAVVCFGESLEQREQNKTIEVITKQVKAFVDLIDNFDNVILAYEPLWAIGTGKTATPEQAQLVHKEIRKIVKDTCGEKQANQIRILYGGSVNTENCSSLIQQEDIDGFLVGNASLKESFVDIIKSAM
Protein: KLHL3 protein (Q8N4I8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPK