wanglab/gogpt-training-data huggingface dataset:
Protein: Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) (O75146)
Organism: Homo sapiens (Human)
Function: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Subcellular location: Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Interaction partners:
- Epsin-2
- Epsin-3
- Clathrin coat assembly protein AP180
- Clathrin light chain B
- Src-like-adapter 2
- Clathrin heavy chain 1
- Huntingtin
- Cyclin-G-associated kinase
- Phosphatidylinositol-binding clathrin assembly protein
- Hematopoietic lineage cell-specific protein
Sequence:
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Protein: Flavin-containing monooxygenase FMO GS-OX5 (EC 1.14.13.237) (Flavin-monooxygenase glucosinolate S-oxygenase 5) (A8MRX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of methylthioalkyl glucosinolates into methylsulfinylalkyl glucosinolates. Specific for 8-methylthiooctyl (8-MTO) glucosinolates.
Interaction partners:
- Cytosolic sulfotransferase 18
- Probable inactive 2-oxoglutarate-dependent dioxygenase AOP2
- Probable 2-oxoacid dependent dioxygenase
- Methylthioalkylmalate synthase 3, chloroplastic
- Cytosolic sulfotransferase 17
- Cytochrome P450 81F3
- Methylthioalkylmalate synthase 1, chloroplastic
- Cytochrome P450 81F4
- Transcription factor MYB28
- Cytochrome P450 81F1
Sequence:
MAPARTRVNSLNVAVIGAGAAGLVAARELRRENHTVVVFERDSKVGGLWVYTPNSEPDPLSLDPNRTIVHSSVYDSLRTNLPRECMGYRDFPFVPRPEDDESRDSRRYPSHREVLAYLEDFAREFKLVEMVRFKTEVVLVEPEDKKWRVQSKNSDGISKDEIFDAVVVCNGHYTEPRVAHVPGIDSWPGKQIHSHNYRVPDQFKDQVVVVIGNFASGADISRDITGVAKEVHIASRSNPSKTYSKLPGSNNLWLHSMIESVHEDGTIVFQNGKVVQADTIVHCTGYKYHFPFLNTNGYITVEDNCVGPLYEHVFPPALAPGLSFIGLPWMTLQFFMFELQSKWVAAALSGRVTLPSEEKMMEDVTAYYAKREAFGQPKRYTHRLGGGQVDYLNWIAEQIGAPPGEQWRYQEINGGYYRLATQSDTFRDKWDDDHLIVEAYEDFLRQKLISSLPSQLLES
Protein: Probable coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (O42937)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit beta
- Putative coatomer subunit alpha
- Probable coatomer subunit gamma
- Coatomer subunit delta
- Probable coatomer subunit epsilon
- Probable coatomer subunit zeta
- ADP-ribosylation factor GTPase-activating protein glo3
- Probable clathrin heavy chain
- Protein transport protein sec31
- ADP-ribosylation factor 1
Sequence:
MMRLDFQRKLLSHTERVKAVDFHPTEPWVIASHYNGQVGIWNYNTQTLVRSFDINDVPIRACAFIARKNWFVCGSDDFQVRVYNYNTGEKVTQFEAHPDYIRALVVHPTQPFLLTSSDDMTIKCFNWDMSWKCVQTFEGHSRYVMSLAINPKDTNTFASSCLDGTVKVWSFGSSVANFTLQAHDRGVNYVNYYPAGDKPYLITAGDDNLIKVWDYQTKACVRILEGHTNNVSFAFFHSKFPIIISGSEDGTVKIWHTLSYSLIKSYNFSLDRAWCIAQNKDNGLVTVGFDNGLITFSLGRDEPSVTMDSSGKVVWSNYNEVMSAMIRPAKEQSDLTDGSLISLSVKELGTTELYPAVLKHSPNGRFVSVCGNGEYIVYTALAWRNKAYGKALDFAWSADSNVYGSRTSDRSIVIHKNFKESNRLDLSYSCDKIFGGFLLGVVGSDFICFYDWDTGILVRKIDVKPKGVYWNDDGRFVILACDDDFYLLGFNAEMFYSAVESGTADEEEGVADSFEALADVSESVVNGKWVAETFIYTTTAARLNYLIGDQTYKIANVESSFYLLGYIPRDDRIYLTDRDMNVVSYSFNLAIIEYQSLVLKGDLEAAQGLLEQISETDRPRLSDFLSRLGYKEAALELSGDSVQRFELALDAQRLDIASQIAQELDDPLKWRSLGDAALNAWDFVLAQECFEKGKDYGSLVLLYTATNNHEGLKELSQLTKSTKINNTAFICSWLTNQPAECVNILTSTQRYPEANLFAATYCPDEVKNVLPEWKVDLTKNQKERIADSLGDLELKN
Protein: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (Q5BK44)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03166}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03166}.
Interaction partners:
- Flap endonuclease 1
- N-glycosylase/DNA lyase
- DNA damage-binding protein 1
- Single-strand selective monofunctional uracil-DNA glycosylase
- DDB1- and CUL4-associated factor 1
- DNA repair nuclease/redox regulator APEX1
- Endonuclease III-like protein 1 lyase)
- Adenine DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase
- Single-stranded DNA cytosine deaminase
Sequence:
MGILGPRPLKLARSLRAPRGARLRSLTPDPDSWQASPAKKARVEQDEPATPPSSPLSAEQLVRIQRNKAAALLRLAARNVPAGLGESWKQQLCGEFGKPYFVKLMGFVAEERKHHKVYPPPEQVFTWTQMCDIRDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIFKELSTDIDGFVHPGHGDLSGWARQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNLNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKANELLQRSGKKPISWKEL
Protein: Cytochrome P450 2C50 (EC 1.14.14.1) (CYPIIC50) (Q91X77)
Organism: Mus musculus (Mouse)
Function: Metabolizes arachidonic acid to several midchain and omega-terminal hydroxyeicosatetraenoic acids (HETE).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15102943}; Peripheral membrane protein {ECO:0000269|PubMed:15102943}. Microsome membrane {ECO:0000269|PubMed:15102943}; Peripheral membrane protein {ECO:0000269|PubMed:15102943}.
Interaction partners:
- UDP-glucuronosyltransferase
- Cytochrome P450 1A2
- Cytochrome P450 2C54
- Cytochrome P450 2C37
- Cytochrome P450 3A25
- Cytochrome P450 2A12
- Estradiol 17 beta-dehydrogenase 5
- Cytochrome P450 2C70
- Cytochrome P450 2C38
- Epoxide hydrolase 1
Sequence:
MDPILVLVFTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQINVKDICQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGMGIIFSKGNVWKNTRRFSLTTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKIMSTPWLQVCNTFPVLLDYCPGSHNKVFKNYACIKNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQENGNYPLKNRLEHLAITVTDLFSAGTETTSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTDAMIHEVQRFIDLVPNSLPHEVTCDIKFRNYFIPKGTNVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLIGLASVPPAFQLCFIPS
Protein: NAC domain-containing protein 1 (SlNAP1) (K4BWV2)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Transcription factor that binds DNA motifs 5'-CGT[AG](5N)NACG[ACT][AC][AT][ACG][ACT]-3' and 5'-CACG[ACT][AC][AT][AGT][CT]-3' in target genes promoters. Promotes leaf senescence and reduces fruit yield and sugar content, probably by establishing abscisic acid (ABA) homeostasis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
Sequence:
MVGKISSDLPPGFRFHPTDEELIMYYLRYQATSRPCPVSIIPEIDVYKFDPWVLPEKAEFGDNEWYFFTPRDRKYPNGVRPNRAAVSGYWKATGTDKAIYSANKYVGIKKALVFYKGKPPKGVKTDWIMHEYRLSDSKSQTSKQSGSMRLDDWVLCRIYKKKNLGRTIEMMKVEEEELEAQNVSTTNNEIEVVGGPQTMKLPRICSLSHLLELDYFGSIPQLLSDNLLYDDQGYTMNNVNNTSNVDQVSSQQQNTNNITSNNCNIFFNYQQPLFVNPTFQSQ
Protein: Probable metalloprotease ARX1 (EC 3.-.-.-) (Associated with ribosomal export complex protein 1) (Q03862)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Nucleolar GTP-binding protein 2
- 60S ribosomal export protein NMD3
- Ribosome biogenesis protein RLP24
- Large subunit GTPase 1
- Large ribosomal subunit protein uL29A
- Ribosome assembly factor MRT4
- Ribosome biogenesis protein NSA2
- Eukaryotic translation initiation factor 6
- Large ribosomal subunit protein uL22A
- Ribosome assembly protein 4
Sequence:
MALAISHEDTQILLKDKNILQESVLNKYRTAGQIAQTALKYVTSLINDSYHSKTTQRQLTVPELCLLTDSFILTRLEQYYKNKVNERGIAIPTTIDIDQISGGWCPEIDDTQNLLNWNKGKDSTFASSVTGTLRPGDLVKITLGVHIDGYTSEVSHTMVIYPVDETKPILQPTGPLLGGKADAVAAAHIAMETVVALLACALTPEKLPASLGGTSSGITGQLIRTIVDTIARSYNCGVVPGSRVRRIRRFLAGQNEGIVAEREYKGVVWTESHQEADLLSNTDAKDLTVVDRGQSTPFTNVSAIPSDDFVVQSGEVYLIDLKMASLEHCTKKGLVTLETVDSYTGKSHKAGELIARPGAYVRDFAQTHILKLKTSRQLLTKIDKQGVYPFKLSHLSSNFPFVHENEEELQSLKKDLKSFRLGMSEISNNYLCVESPIQIARWVPWDHILKATNPNGNLSYDATSTLTLPGHELPLPKLGVSAIKLKSLMNSTKESISLPVARECNTIVLCDSSVSTTDRPELLRLTGGSKTCQPSWIHSQHELNPQDSIVQGIFQLATLAKDKRFGLLLKETQPMKQKSVETSNGGVEETMKM
Protein: Error-prone DNA polymerase 1 (EC 2.7.7.7) (Q8UAY9)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Function: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
Interaction partners:
- Uncharacterized protein
- Damage-inducible protein
- DNA polymerase III subunit epsilon
- DNA polymerase III subunit gamma/tau
- DNA polymerase III subunit delta
- DNA polymerase III, delta prime subunit
- Beta sliding clamp
- Single-stranded DNA-binding protein
- DNA polymerase III subunit chi
- DNA polymerase III, epsilon subunit
Sequence:
MSAPRYAELQVTTHFSFLRGASSCDELFEQAKNLGIEALGVVDRNSLAAIPRAYEAANNHGVRLVIGCRLDLDDDLSVLVYPMDRAAYGRLCRLLSVGKKRGGKGKCRLSWDDLVAYGEGLIVVLLADLADDLCALRLRRLKAAFADRAYMALSLRRRPNDQMRLFELSGMAQAAGVPTVVTNDVLFHVPERRMLQDVVTCIRHNCTIDEAGFRRERHADRYMKPPEEMHRLFARYPEALSRSLEIAKRCKFSLKELVYQYPEERSLPGLTAQQALEKMVWEAVPGRYPNGLPEKVEKALHHELDVVGRLQYASYFLTVNAIVRYARSKDILCQGRGSAANSVICFVLGITAIDPALFSNLVFERFVSENRGEPPDIDVDFEHQRREEVIQWVYDTYGRDKAALCSVVTRYRGRGALRDVGKVLGLPEDLTKLLSSQVWRWSEGVGEKQVKELNLNMEDRRLKLAFELANQLVGTPRHHSQHPGGFVLSHDRLDELVPIEPAAMNDRQIIEWDKDDIDIVKFMKMDCLALGMLSCMKRGFDLLEARTGEKYDLAAMPPDDPATFAMIQKADTLGTFQIESRAQMSMLPRLKPAKFYDLVIQVAIVRPGPIQGDMVHPYLRRRQGKEPVLYEKPQLENILKKTLGVPLFQEQAMRIAMDCADFTADEADQLRRAMATFKNVGTISKFKEKLVTGMVANGYDKEFAERIFKQLEGFGSYGFPESHAASFALIAYASSWLKCHHPDIFCTAILNSQPMGFYAPAQIVRDARDHGVEVRPVCVNNSRFDCTLEPTGKKNDKGEERFAVRLGLRMVKGLSNDHAADIVAARQDRPFASVDDLWRRAGVPAAALVCLAEADAFLPSLRLARREALWAIKALRDEPLPLFAAAAIRENAVIEELQEPSVALRPMTDGGEVVQDYGHVGLTLREHPMTFLRRDLSRRRIVTCAEAVRVRDGTWLETAGLVLVRQRPGSAKGVIFMTLEDETGIANAVLWVKTFEKYRRVVLSAGMVGIYGKIQREGEVVHLVAHRLTDLSHALASVGERNNAFPLPHGRGDEFHHGMPDDHRAIRKRPPPSNHDDDEVERIKVISRNFH
Protein: Pentatricopeptide repeat-containing protein At2g02980, chloroplastic (Protein ORGANELLE TRANSCRIPT PROCESSING 85) (Q8LK93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA editing event in chloroplasts. Required for the editing of a single site in ndhD transcript, which is a plastid-encoded subunits of the chloroplast NAD(P)H dehydrogenase (NDH) complex. Not essential for the activity of the NDH complex of the photosynthetic electron transport chain.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19934379}.
Interaction partners:
- Phosphoglycerate mutase family protein
- Organelle RRM domain-containing protein 1
Sequence:
MAISSASLISSFSHAETFTKHSKIDTVNTQNPILLISKCNSLRELMQIQAYAIKSHIEDVSFVAKLINFCTESPTESSMSYARHLFEAMSEPDIVIFNSMARGYSRFTNPLEVFSLFVEILEDGILPDNYTFPSLLKACAVAKALEEGRQLHCLSMKLGLDDNVYVCPTLINMYTECEDVDSARCVFDRIVEPCVVCYNAMITGYARRNRPNEALSLFREMQGKYLKPNEITLLSVLSSCALLGSLDLGKWIHKYAKKHSFCKYVKVNTALIDMFAKCGSLDDAVSIFEKMRYKDTQAWSAMIVAYANHGKAEKSMLMFERMRSENVQPDEITFLGLLNACSHTGRVEEGRKYFSQMVSKFGIVPSIKHYGSMVDLLSRAGNLEDAYEFIDKLPISPTPMLWRILLAACSSHNNLDLAEKVSERIFELDDSHGGDYVILSNLYARNKKWEYVDSLRKVMKDRKAVKVPGCSSIEVNNVVHEFFSGDGVKSATTKLHRALDEMVKELKLSGYVPDTSMVVHANMNDQEKEITLRYHSEKLAITFGLLNTPPGTTIRVVKNLRVCRDCHNAAKLISLIFGRKVVLRDVQRFHHFEDGKCSCGDFW
Protein: Phage repressor-like protein (B9DUC0)
Organism: Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Interaction partners:
- ImpB/mucB/samB family
- YolD-like protein
- Uncharacterized protein
Sequence:
MFSGKQLKTIRQKHQMSQESLGQKLGVNKMTISNWEKGKNVPNQKHLNQLLEIFHLDADSFNPYQAIILPYKQLTSLNQEKVVTYSKELLEEQNKIVQLSQSQKKLYVYRVYESLSAGTGFSYFGDGNYDEVFYDEQLDYDFASWVFGDSMEPTYLNGEVVLIKQEGFDYDGAIYAVEWDGQTYIKKVYREEDGLRLVSLNKKYSDKFAPFDENPRIIGKIIANFMPLEV
Protein: Centrosomin's beautiful sister, isoform C (A0A0B4K864)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFATLKNKIKEETGDDVVQSANQRYPGNNNNNYRLRSRRVSINSNSADDVGGGGFYNESEQLCELRSQCNELTTKLSTVTQGLQQLQEEKTRVDKTNEILLESVRVAQTQKDIYCEEQEKIQNLQQIEIDKLKNLLSFREQESVDRMGLMRQQTQQIESLSEELERLRPIESVAEDLRDELEQLRHSTQQEKNLLTTTLAAVQEENRHLKKRMKIVEESRLESLGKLNSEQQVQALIREHKLLEQHLEEAHLQLSDIKGSWSGQNLALETQVSRLSKQVAEETTEKRKALKSRDDAIESRKQVSFELEKAKDEIKQRDDKVKLLEEEIDELSVALKECREENEQQVLFERNKSQNLETEVKDLKTRLTAADDRFSEYSSNAEQVAQKLRVQVTEKQEQLDETIMQLEIEREEKMTAILRNAEIAQSEDILRQQLRLERSEASDLQERNNQLVRDISEARQTLQQVSSTAQDNADKLTEFERVQLEIIEKNKTIKTLNQRLIDLKKTVQKELRSAQISTDSESHPTTTPGHRISSSSLEAFSTGDKGNCVIMDEVNFQYLKHVEARHLVRAVSTLLQLTTEEEKLLHDTLNWKMSWFGMKPT
Protein: Ceramide kinase-like isoform 31 (G0XYH9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDCIPTLVGAELPLGFIPAGSTNALAHSLFGTPHVVTATMHIILGHIRSVDVCTFSSAGKLLCFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAIIKALAKLKKSQRSAESDCGGHWQTIQGQFLNISIMAMPCPCSMAPRGFTPDTRLHNGSMALRVVRNTTRSEFVKHLKRHSSVKNQGLYRYN
Protein: Flotillin (Q5ST80)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004543}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004543}. Membrane {ECO:0000256|RuleBase:RU366054}. Endosome {ECO:0000256|RuleBase:RU366054}.
Interaction partners:
Sequence:
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
Protein: Osteopontin (Bone sialoprotein 1) (Secreted phosphoprotein 1) (SPP-1) (P31096)
Organism: Bos taurus (Bovine)
Function: Major non-collagenous bone protein that binds tightly to hydroxyapatite (Probable). Appears to form an integral part of the mineralized matrix (Probable). Probably important to cell-matrix interaction (Probable).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P10451}.
Interaction partners:
- CD44 antigen
- Integrin beta-1
- Integrin alpha-V
- Integrin beta
- SPARC
- Stromelysin-1
- Osteocalcin
- Integrin alpha-9
- Integrin subunit alpha 4
- Integrin beta-5
Sequence:
MRIAVICFCLLGIASALPVKPTSSGSSEEKQLNNKYPDAVATWLKPDPSQKQTFLAPQNSVSSEETDDNKQNTLPSKSNESPEQTDDLDDDDDNSQDVNSNDSDDAETTDDPDHSDESHHSDESDEVDFPTDIPTIAVFTPFIPTESANDGRGDSVAYGLKSRSKKFRRSNVQSPDATEEDFTSHIESEEMHDAPKKTSQLTDHSKETNSSELSKELTPKAKDKNKHSNLIESQENSKLSQEFHSLEDKLDLDHKSEEDKHLKIRISHELDSASSEVN
Protein: Nuclear receptor Rev-ErbA beta variant 1 (F1D8P2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
Protein: Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) (Q9EQ31)
Organism: Mus musculus (Mouse)
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Lysophosphatidic acid receptor 6
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 5
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 1
- Prothrombin
- Angiotensinogen
- Proteinase-activated receptor 1
- Muscarinic acetylcholine receptor M1
Sequence:
MNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLTASLANLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVAVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCALQDSNTERRPSRNPSTIHSRSETGSQYLEDSISQGPVCNKNGS
Protein: Meiotic driver wtf19 (A0A482APN3)
Organism: Schizosaccharomyces kambucha (Fission yeast)
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus; the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, leading to poisoning of all progeny that do not inherit the allele.
Subcellular location: [Isoform 1]: Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. {ECO:0000250|UniProtKB:A0A218N034}.; SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm {ECO:0000250|UniProtKB:A0A218N034}. Cytoplasm {ECO:0000250|UniProtKB:A0A218N034}. Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1. {ECO:0000250|UniProtKB:A0A218N034}.
Interaction partners:
Sequence:
MKNKYYPVRTSMDEMNAKNDNEIDLEKGPLPEYNSEDGSTLPPYSENLNLKDPKQMGANNPNLFNTDESTTPPDYGEDSLSNTHRENHSSGTADNSSPFLIKLLISFIPIFVLNVPAVCYLTYKDALFKDYGKDEWVYFGVWCAICLMIFISLWCFYETWTQAVAQCVKVTVIFLAQCIKVTVISLAQCVKVTAIFLAQCIKVTVISLAQCVKVTAIFLAKCVKVTVISLAKCVKVISIGLFNIRREMMIIIWILWLIICCILFGCVKDGRLNFNKALICSTCTISAVLFLIVSSVCIPIWTLWRALSGMLQVLGIHGIIAVLVNGLMSLFGKHFGWRGYEIEGFVLFFTSSALFLYEMERPGVLKRLRNTTGNVIGYICGGIEDAFRRIKNAFRGANDNNNIPLGEMDVEGEV
Protein: Uncharacterized protein (Q389A8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKATKDPKVGQNLVRMDGRRKCDPTDFDTLYLDMLSEIATVSEHRASIIKSAFPSLHALLEAIDSGTLERVRVRGYDEERSCSTLDPYISKVLSTDYTATGSVEGAASLVEVSKKFFQQSSEK
Protein: cAMP-dependent protein kinase type II-alpha regulatory subunit (P12368)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane. {ECO:0000250}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase type II-beta regulatory subunit
- A-kinase anchor protein 7 isoforms delta and gamma
- A-kinase anchor protein 10, mitochondrial
- A-kinase anchor protein 5
- 5'-AMP-activated protein kinase subunit beta-2
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- A-kinase anchor protein 1, mitochondrial
- Protein kinase cAMP-dependent X-linked catalytic subunit
Sequence:
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVDFAVEYFTRLREARRQESDSFIAPPTTFHAQESSGVPVIEEDGESESDSDDEDLEVPIPSKFTRRVSVCAETFNPDEEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSDGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSKTKTNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSNLDLLDPGQ
Protein: Viral transcription factor IE2 (IE2) (Protein UL122) (P19893)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. In addition, activates quiescent cells to reenter the cell cycle and up-regulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.
Subcellular location: Host nucleus {ECO:0000250|UniProtKB:Q6SWP7}. Note=Colocalizes with host PML-associated nuclear bodies. {ECO:0000250|UniProtKB:Q6SWP7}.
Interaction partners:
Sequence:
MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSVSSAPLNKPTPTSVAVTNTPLPGASATPELSPRKKPRKTTRPFKVIIKPPVPPAPIMLPLIKQEDIKPEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGTPRVTSPTHPLSQMNHPPLPDPLGRPDEDSSSSSSSSCSSASDSESESEEMKCSSGGGASVTSSHHGRGGFGGAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFCTPNVQTRRGRVKIDEVSRMFRNTNRSLEYKNLPFTIPSMHQVLDEAIKACKTMQVNNKGIQIIYTRNHEVKSEVDAVRCRLGTMCNLALSTPFLMEHTMPVTHPPEVAQRTADACNEGVKAAWSLKELHTHQLCPRSSDYRNMIIHAATPVDLLGALNLCLPLMQKFPKQVMVRIFSTNQGGFMLPIYETAAKAYAVGQFEQPTETPPEDLDTLSLAIEAAIQDLRNKSQ
Protein: Nicotinamide riboside transporter PnuC (P0AFK2)
Organism: Escherichia coli (strain K12)
Function: Required for nicotinamide riboside transport across the inner membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15561822}; Multi-pass membrane protein {ECO:0000305|PubMed:15561822, ECO:0000305|PubMed:15919996}.
Interaction partners:
- Quinolinate synthase
- Trifunctional NAD biosynthesis/regulator protein NadR
- L-aspartate oxidase
- Nicotinate phosphoribosyltransferase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Nicotinate-nucleotide adenylyltransferase
Sequence:
MDFFSVQNILVHIPIGAGGYDLSWIEAVGTIAGLLCIGLASLEKISNYFFGLINVTLFGIIFFQIQLYASLLLQVFFFAANIYGWYAWSRQTSQNEAELKIRWLPLPKALSWLAVCVVSIGLMTVFINPVFAFLTRVAVMIMQALGLQVVMPELQPDAFPFWDSCMMVLSIVAMILMTRKYVENWLLWVIINVISVVIFALQGVYAMSLEYIILTFIALNGSRMWINSARERGSRALSH