Protein: Kettin homolog (V6CLP5)
Organism: Caenorhabditis elegans
Function: Positively regulates actin filament organization and provides mechanical stability to the myofibrils during body wall muscle contraction. Required for the organization of sarcomeric actin filaments and myosin protein myo-3 in striated body wall muscle cells. Not required for assembly of dense bodies, which are a type of integrin-based adhesion structure that link the plasma membrane to thin filaments of myofibrils, in body wall muscle. Not required for the atn-1 protein to localize to the dense bodies.
Subcellular location: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:10669599, ECO:0000269|PubMed:16453162, ECO:0000269|PubMed:31411810}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16597697}. Note=Localizes to sarcomeres in a punctate pattern (PubMed:31411810). Localizes to actin filaments (thin filaments) close to dense bodies in body wall muscle (PubMed:16597697). Co-localizes with actin filaments in embryos and adults (PubMed:16453162, PubMed:31411810). {ECO:0000269|PubMed:16453162, ECO:0000269|PubMed:16597697, ECO:0000269|PubMed:31411810}.
Interaction partners:
- Actin
- Alpha-actinin, sarcomeric
- Flap endonuclease 1
- Troponin T
- Muscle M-line assembly protein unc-89
- Paramyosin
- TropoNin T
- Calmodulin
- Troponin T, skeletal muscle
- Troponin T
Sequence:
MPFKQPLGERDAANRVAPTFIRPLADKRAVVGETIILECQLEGHPDPAIKWLKDGHNVSMCPDYRIEEDGLKHRLVIPQVQAADSGRFTAQASNSAGTKQSTCILICAPAPTPVPGAKSAVASPAPPQTPVGPSAPIFLKELRHQPLKPGAGVTFEGRVIAVPPPNIEWMKNGKPLQNYRAKIEHDQKTGIISLIIPQMFNDDAGEYTIKATNVHGEAISGAQLLPREQYDRWFSNEQTRLTKDRKQGLLSQTLRPSSVAQKQMQKQGYDTDQGSVDMHWTISESETEPELSALDARGVGTKPIIRTPLRGLRLTEGTDAILQANIVGNPKPRIQWLFNGRPLQVSGPRMQMTYKGSMAVLKISMVTTEEAGDYTVASENRFGKVESSARIEVYPLSVPDERRKENQLREQQERDRQQQQQALVEASLARERQRDAENRRIREEQDRLRVLFEREKAERERLEEERRQLEHEKRLRQQQQQQLFEREKSEKEERARLEEERRRLEHEKHLRQQQQTQPYNLHYQQHHQPHQAWQDLDLVRRPQYASDEYQEPHYAQIRPHQQQQQHYQQQQQSPRQEVTHQNLYEQHRRQQQLIREQQLYQHQHQQHQQQQQQPQEQQQQRFHHFNQYQQHIREQHQNTMPVFRQQQPTQVTNGGIKAANGSAKTANGSANGSANGSAVHAANGGPSSQQARGHEHGAALVNARPPQFLVHPQSVAAKAFETVTFSAKVVGTPTPSLTWQKSDGTVIQSGGKYKIENGPDGSGRLIIEKVDAHDADMYMLVARNDGGSFQSRFSLNVLQAKSPEAPEFTGKFQSTTLYDGDSVKLYCKAAGEGVSFKWFKDNEPISSGGSYAVDNKGNETTLHINNATMKEGGWYRCDATNKHGTTTLKGRVVVNSRQKFNGPAHREMITLRKVDKVERSRTPVNQLQDVSASKSSPKFEGSLQSQQLVEGQSARLEIKYTPVEDPNLRIAWLLNGKGILASSRIVTFTDFGIAALEINPVNVFDQGEYTVVAVNPLGEARVSANIAVIGHGSFIQQQQSGSQFGGTAYQSKGAQAPAGTHLDLPNFHSDLRSQEVFEGQQIHLETKLTPINDPDLRVVWLLDGNELPSNDKYRQTLSHGFASLDIPQTSSNDSGLYSCRAFNKLGESENQATIIIVPKSDLQQFEQHRQLDVEDVREIQFAHSSQDLTPKFLSQIQPFHCEQELGRSFFEARIQPINDPTLRVSWLKDGQPLPNANRIQIFQNFGVVSLSLHPTYPEDAGVYTCVLFNSHGQAQSSAELTTVWIDTLQLDSKHADSLPIIGYLDSHQIHIGPQSVERPEEFNSLEAPKFARELAGKIEVMENERVHFEARILPANDVKMTVEWYHNGNPLPAAHRFHPMFDFGYVALDLLYAYPQDSGTYTLVARNELGEARSNVELVVGTEKVLYLEPHHPEGLERIKELEQDRRQGIAEVEDRTCDAAPKFLNDLPDIQLNEHENIHVDLRATPVNDPTMVIEWFVNGRPLLTGSRVKTLNEFGFIALDIKGAIAEDSGTYSVRASNLLGEAIRQCVITVTPAGQILSDTQHQESLGKINYLENLNKYGRVEIEDKGPQEPPTFVVPLQADLGDVEEGEPIHLECQVNPINDNSLKIIWLRDGQSLPHGHRFRTFYDFGFVSLDILGFYAQDAGTYTCRAENSLGQAETVATIRCAPKDAILGAVQHPRSYARIQEIEAPKPAPQEVPDLPHQPPAFVKQLGPAIQCMEGDNVYLEAQVTPTDDNSLTYEWLVNGQPLMKAHRFVLSQDFGYIALNILYCYPEDNGTYTLVVRNRAGEAQSTVDINCGHTGGNFTDSFHPNSLHRIAELETPIQRAEPLPDKEKEVPTIAKPLPATIDSVHESQTLHLEAQVTPIDDNTLRYEWLFNGNPLKASSRYRVLNDFGFVSLDIDYIIAEDSGKYTLVVYNSAGRAETSCEFQVDRLKSILSDTAHPESLRRIREMEQLQPAKPSDDDAAAQPPVFTQQLTGPTEPLKEGQSVHMDCVVQPINDPSLRIEWFHDGRPLMFGSRIRTIHDFGYVGLEFLHIHPEDTGTYTCKATNLIGEATTDIFLECKPRRNIYLDTHHESSWQKIQEIENRVDEREPTPELTFQPPTFTENLADKEDAQEGQSIRLECRLIPVNDPTMRVTWTRNGQPLPEASRFMPARNFDYVNLDILALYGEDSGVYTCKAVSAFGEAATSCTVKCAAGKSLLLDTMHDASWKRVQEIENREKLEAVDAEPEKTAPKFVTQLNSSLGELQEGVPIHLEAQVEPTNDNQLTVQWFHNGQPLANGHRFRTRHDFGYVALDILYAFAQDTGEWACVARNSLGEAQTIANFTVLPRGTIYTDSQHPESWQKIQVLEAPRAAAPEKPDAEHDAPQFIEPLDSIDRMEFQSAHFQTKVTPQTDPNLRIQWFKDGQPLMNSNRFKLTTDFGYISLDIAHTVPEDSGVYSVKASNAKGDAEVQAQLTVTGNAVILGDTQHEQSWQKIQLIEAPRAPGEEEPDVKHGPPKFVTQLHSLDGVVEGQPSHFEAQFIPFSDPKTSVQWYLNGNPLSASSRRILRNDFGLVSLDLQYTLGEDAGEYSVVVKNSEGEDRTSGQLSCTTRAAILGDTQHEQSWQRIQEIEAPRAPGAEPEGPVYEKPSFVQPLQSVGDLPEGSVALLEARLVPVNDPNLRVQWFYNDQPLMESNWISTSNDFGCVSLRIAPVYARHTGVYSCKAWNDSGNAVTSANVGVQGSEGLLLDTSHPASLQKIQELEAIDKYARLDAPEREYEKPQWVQGFENYENVGEGQTVTLHGLVEPSGDPHLRLEWLLNGTPLRNANRFRQEYEFGNAILTIVHVLPHDSGVYTCRAWNTQGEASTSATVTTAGYEKILYDSQHPVSWERIQELEAPKIVEEIEEIVQKEKPNFLTQLESAENVPEGVPLHLESTFQPARDPELKVVWQKNGQPLGASQLVQTKHELGWATLDISSANEDHNGVYTLTITNSEGEAVSTASIRVAGTGPILGNTRHEESWKRIQILEAPKEAEPEAPAPVYDHPAITTQIDDKECNEGDHVHFEALITPVNDPRLQVQWIRNGVPLAHGSKYAIQQDFGICTLDVAYTYPEDEGVYQLRIWNPEGEAVSSATLKCHGKDAILGDVQHQESWKRIQEIEAPKQKLEEADPEPKGPPRFIQQLTSPGSLVENQPAHFEATVEPVDDPTLTINWFLNGEPMSASSRVKMINDFGWVIMDIAQTEPRDSGEWKCVAKNAAGEAVSTATIEVQGKEVILQDSLQPQSLDRIRQIEAGKPAPEERPDQQFEAPAIVNALQVQGALEEGGSAHLQTQFTPVADPSIKVEWLKDGQPIFHSNRYKMVHDFGFAVLDILHLLKHDAGEYTFRVSNNSGEASTSTSFEVSESSGLILQPQNEQKAKAVEILEDNLRRRPEEIEQELKEATPVFIEPLSAPVETEEGGRAHFTARYEPVNDNQLQVQWYHDGRPLKNGSRIKTINSFGYVVLEISPTYPEDNGEYICRAVNRVGEAVTSTKLTCTPKEGIISATQLPERMANAGRRIAEIEAPRPAREDAPDADHGPPKFTSALAGPPELQEGQQAHLECQVTPVADPRLVIEWFHNGQPVNHTNRMKAIHDFGFVVLQLTPAEPQDSGTWTCRATNQHGSDEVSTELKVVGGGGVSYEWQSTAERKERITELEDWIHRPKEDLNLPAVDYPAPSFSQGLTDLGQLNEADATAFVCVLEPIGDPTLRVQWEHNGHPIPYSNRISCTNEFGVATLLIKHLIAADAGEYKCVATNVKGSATSVGKIAVESSTQIDAPQVVQQLVDSVENILEGDSIHLECRVTPINDPRLHVEWLRNGAPLPEASRFKPTFEFGFVSLDILYAYPEDNGDYELVVRNDKGEARSKTKITVLPRPSLDYTSQTHGNQQDSLESHFKQHSQAKLQLTANDIYNESDKRAPEFRTQLQNIGVLEGEFCRFETQVAPINDPYLKVEWFKDKKPVLLGHRFRSTLDFGFACLDLLYALPDDTGEYHCVATNRHGQTMISAKLACQGASHVITDSQMPQGLRVSNVKKDNKNIYWSEQGGAVQPKQKQAPQFTIPLRNLQVTENQPARFECAVTGYPRPKVTWFINGNQCLHGHRFKLNFDGLHYLTVSKSRISDAGEVVAIARNTEGETISTATLDIFQNDDFRQTKLRPANFKTSDELRERELQWQRDTLGSLGPAFEAAPKPDAQKLMHVERAQSPIEPMESQELIQKFTRPRDDNFYNKLSYVELQKPQFKGMELEEVNLKAGKVEKYQPPVEEMERVNLKAIPEKDQQEVGWERPDWAGQDGTSKLPGADEGRFKKLPTPAPELDVPARDQVKLKTAKPTRGKDLEAGEKVKLKTEKAKIKEIQQKPEQPKEEPIVHKDAVQLKTQQLPKTGIKGDHFTVDREKDLKETPAVVKPVIEETRISNKSISNVVHESSEYTSSYASNQSRLTYQAYREHKESTSSDVYLSVETADSFSQVQRLEYSPRSPRRERIIGFHMIRPQPTKIGQSKQAPPTISQQLKPLQGELGKAAKFVIEFAGAAPVKVTWLKDGKEIKSTFRTLITTTPTNSSLHIGRLENSHAGEYTVRLENAAGTVESLANLTVAPPTTQGKAPDFSARLNDLRIQQNGPAEFSCQIGGEPKPTIQWFKDGQPLPNDDRFQVVEEGGAYKLKFSNIISTDAGIYEIVAKNGVGEARCKARLNVNLQKTGKGAEEGPRYEAPRFTSQIQPIVVDEGKGAQFSAQFSGFPDPTIRWYRNNEPVKHADGYEISQSKGEAILRISAARNEDVAEYKVEASNPAGKASSVANLVLTPRSGRIAKSTISRGGSASYQSSDKAAADSPHFIAKLSDISARQGHTVKFSAEVDGNPEPTVQWQFKGKPISASNNVKISRDGKRAILELARVTPDSAGEYQIVIRNDKGAATSQAKLTLSR