wanglab/gogpt-training-data huggingface dataset:
Protein: Transmembrane protein (Q38FY4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWGLTRRCPPMGLARISAAWMCGARSVSSNSAASGGDDTKERLPWSTTPLTSSTSAATAAERTGVYGVKGYGFMEGFRVLGPTAALGRLKAMLSLYAVLSAAAFGGTVWFMTTKSYVLTTDPDPKSDARRKTFSCDYAVVRNRWTGRRCVIDVATCSSSSNAIASDACSNDSGTSAVPTRGINFTQQHIKVNWLIHSIRLYLHATDSVVVVDLAPLLHPYRFTLDRQRLLSATPSFSKYDEPVSGRDGKNCVEKPRLLFRSRVRPALVRNYSQNGTFPQYELTLQSVAEELLTERYRRAILSRGYSCTHPAVLEELLRNGQLNGEGLAWEDVVGDSVSFAKEVQRRVEQRMKDQVVLLHCDIAFVR
Protein: Inositol diphosphatase siw14 (EC 3.6.1.52) (Inositol pyrophosphate phosphatase siw14) (Q9UUF3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GTP-binding protein ypt1
- Heme A synthase-mitochondrial ferredoxin fusion protein
- Protein pim1
- RCC1 repeat-containing protein C10F6.04
- F-box protein pof9
- Peptidyl-prolyl cis-trans isomerase B
- BTB/POZ domain-containing protein 1
Sequence:
MAIVFPFQLEKKLISITSDRDQISMSIPEVSSHDSCLNDCHSVNSEEQAKPVCCLELNAHKDGIKVVDTSNDASTFSNSPLVPDNFGVVYPGIIYRSACPRASNFNFLESLHIRTIISLRQEEYSEEDLHYFTKHHINYYHIAMPGSKHRKNDCISSSSNPDISDVDDLVRKTLQLLLNKENWPVLLHCSRGKHRTGIVIGCLRALMNWPVGNRLQEYISFSHPKEREVDEEYIQNFSSDPSLKSSLNDLKRYISDSSSELADVVLSSESPTVQAATVNETCRSPGS
Protein: Cell wall protein TIR4 (TIP1-related protein 4) (Q12218)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cell wall. Required for anaerobic growth.
Subcellular location: Secreted, cell wall {ECO:0000305|PubMed:10383953, ECO:0000305|PubMed:9613572}. Membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Seripauperin-24
- Cell wall protein DAN1
- Seripauperin-15
- Seripauperin-23
Sequence:
MAYSKITLLAALAAIAYAQTQAQINELNVVLDDVKTNIADYITLSYTPNSGFSLDQMPAGIMDIAAQLVANPSDDSYTTLYSEVDFSAVEHMLTMVPWYSSRLLPELEAMDASLTTSSSAATSSSEVASSSIASSTSSSVAPSSSEVVSSSVAPSSSEVVSSSVAPSSSEVVSSSVASSSSEVASSSVAPSSSEVVSSSVASSSSEVASSSVAPSSSEVVSSSVAPSSSEVVSSSVASSSSEVASSSVAPSSSEVVSSSVASSTSEATSSSAVTSSSAVSSSTESVSSSSVSSSSAVSSSEAVSSSPVSSVVSSSAGPASSSVAPYNSTIASSSSTAQTSISTIAPYNSTTTTTPASSASSVIISTRNGTTVTETDNTLVTKETTVCDYSSTSAVPASTTGYNNSTKVSTATICSTCKEGTSTATDFSTLKTTVTVCDSACQAKKSATVVSVQSKTTGIVEQTENGAAKAVIGMGAGALAAVAAMLL
Protein: Nucleolar GTP-binding protein 2 (Q7SZQ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU364023}.
Interaction partners:
Sequence:
MVKAKFKGKSSINTSNSSSNPDRVKGAGGNNMRDRATIKRLNMYRQKQRCNSRGKVIKPLQYQNTVAPGTVARVEPNIKWFANTKVIKQSSLQKFQEEMNAVKKDPYRVVMRQSKLPMSLLHDRIKAHNSKVHILDTETFETTFGPKAQRKRPNLSVGELKEFAEQAEVSAQSYSAEKDRDLVSEDSGVKEEAREEIFKKGQSKRIWGELYKVIDSSDVIIQVLDARDPMGTRSQSIETYLKKEKPWKHLIFVLNKCDLIPTWVTKHWVAVLSQEYPTLAFHASLTNSFGKGSLIQLLRQFGKLHSDKKQISVGFIGYPNVGKSSIINTLRSKKVCNVAPLAGETKVWQYITLMRRIFLIDCPGVVYPSDDSETDIVLKGVVQVEKIRNPEDHIGAVLERAKAEYIQKTYRIPSWSSAEDFLEKLAFRTGKLLKGGEPDLPTVSKMVLNDWQRGRIPFFVKPPGVETDEENKAQAMLEMPEMESEMDELENRLEAQDVEEASSSQHEEQKLLKKKKEEVQKLFNDVKQNFGKINVAPEFSEEDLVPVEMPDMMDASGSEDEENEEEEEEEDDEEKAEEETGEQQEEESSVSDSTPKAGKKSTQEVNKEMDEKIAKLKHFLDRAKSKHFSAIRIPKGLSERVFTETVAKQNAAKNQQQKAVKQGKRRRAVEDEPAQPAKLTSKEKRRIERAQKVKKVGVRYYETHNVKNKNKNRKIPSDGKKANRAKR
Protein: Solute carrier family 25, member 54 (B1AUS6)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
- EEIG family member 2
- AKNA domain containing 1
Sequence:
MLRRLQDFLLPSEACQNDYNRLAYEVLFEDLDHNGDGVVDITELRDGLKHWNSSFSEDTEKEIFMDADSNADSGLDFEEFVQYLQDHEKKMKLAFKSLDKNDDGVIDASEIVAAVRSLGIHISLSQAKDILKSMDFDGSMTVDWDEWRDFFFFHPAKNITDIVRFWKHSTIIDIGESISIPDEFTEQEKMSGEWWKRLVAAGIASAITRTCTAPLERLKVTMQVQSLKVNKMGLVHMFKQMVKEGGFFSLWRGNGVNILKIAPETAIKIGAYEQYKKLLSFDGDHLGVLQRFTAGCMAGATSQTCVYPMEVIKTRLNLSKTGEYSGLVDCVRKLLKREGIQAFSKGYVPNLLSIIPYAGLDLTIFELLKNHWLEHYAGNSVNPGIAIVLGCSTVSHTCGQLASFPLILVRTRMQAVMLEKETVRMMQLIQEIYTKEGKKGFFRGFTPNVLKLLPAVGIGSVAHELVKRLFGLI
Protein: Kinesin-like protein KIF21B (O75037)
Organism: Homo sapiens (Human)
Function: Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXL1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:F1M5N7}.
Interaction partners:
- Tripartite motif-containing protein 3
- Kinesin-like protein KIF11
Sequence:
MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMATSEEEQGIIPRAIAHLFGGIAERKRRAQEQGVAGPEFKVSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKIHEDANGGIYTTGVTSRLIHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDGTPPSSEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARSPYSLGASPAAPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEMVLRRKTQEVSALRRLAKPMSERVAGRAGLKPPMLDSGAEVSASTTSSEAESGARSVSSIVRQWNRKINHFLGDHPAPTVNGTRPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDGITDCQATIVQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMAGSSQNHLLLDALREKAEAHPELQALIYNVQQENGYASTDEEISEFSEGSFSQSFTMKGSTSHDDFKFKSEPKLSAQMKAVSAECLGPPLDISTKNITKSLASLVEIKEDGVGFSVRDPYYRDRVSRTVSLPTRGSTFPRQSRATETSPLTRRKSYDRGQPIRSTDVGFTPPSSPPTRPRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGIISPVGGAKGARTAPLQCVSMAEGHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSTSYIKVWDIRDSAKCIRTLTSSGQVISGDACAATSTRAITSAQGEHQINQIALSPSGTMLYAASGNAVRIWELSRFQPVGKLTGHIGPVMCLTVTQTASQHDLVVTGSKDHYVKMFELGECVTGTIGPTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFIPGRPMLLSACRAGVIKVWNVDNFTPIGEIKGHDSPINAICTNAKHIFTASSDCRVKLWNYVPGLTPCLPRRVLAIKGRATTLP
Protein: Fimbrin (A0A1D8PPY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Actin
- Scp1p
- F-actin-capping protein subunit beta
- Profilin
- Abp1p
- Centractin
- Cofilin
- Actin cytoskeleton-regulatory complex protein SLA1
- Coronin
- Tropomyosin
Sequence:
MNVLKLQKKYPVLDQSDLFSIIEDFRAIDLDDKGWVEKKDVINAVSKKGEYSYDQARETLKQVDVDASGHVELDDYVQLMAILKEDSSSATPPPPSSTISGNSATSPSVVSPKFKKPPPPIPTANSKNKTFLGGKTSGTTHTINDEERTEFTRHINSVLAGDPEIGDRLPFDTETFQIFDECRDGLVLSKLINDSVPDTIDTRVLNLPKPKKTLNNFQMSENANIVINSAKAIGCVVVNVHSEDIIDGKEHLILGLIWQIIRRGLLSKVDIKYHPELYRLLEDDETLEQFLRLPPEQILLRWFNYHLKNAGSQRRVTNFSKDVSDGENYTVLLHQLQPEYCDLSPLKTSDLLTRAEQVLTNADKIGCRKYLTPNSLVSGNPKLNLAFVAHLFNTHPGLQPIEEHENIEIEEFDAEGEREARVFTLWLNSLDVDPPVVSLFEDLKDGLVLLQAYDKVLPGSVSWKHVNKKNNGEVSRFKALENTNYGVEIGKANGFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNIVNTLADLGKGGHNLSDADILKWANQQVSKGGKSSNVRSFSDSSLSNGVFLLDVLNGLKPGYVDYDLVYTGNSDEEKYANAKLAISIARKLGALIWLVPEDINEVRSRLILSFVGSLMAVSEK
Protein: Protein arginine N-methyltransferase (Q5BH46)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Polyadenylation factor subunit 2
- Regulator of volume decrease after cellular swelling-domain-containing protein
- Protein kinase domain-containing protein
- Serine/threonine-protein kinase RIO1
- Mitogen-activated protein kinase hog1
- Histone H4.2
- Histone H4.1
- Catalytic subunit of the SWI/SNF chromatin remodeling complex
- Actin-related protein 4
Sequence:
MESESVAPSFCIGQHESKRTIPITSEVVQLAHESNYDMLTTPITTPHFQSRVLSLLSSHLSNIQAVSHSDSGTLMTTENIRPLVMPQLGPADTHLTPNEAMSQLVGVTSSWIDLCSPDPLIADLSRQVFMLEVAYAAFCGIGYLLIPGPKLHHKGMHSDGVMYYARAIQDALSLGPYIQFHIWLDMVDNQDLELDEMGDLAPLAREEFFDTEIEQPKIDLFGTWDAWDAIRRTCKYHSRLFVALSLPKHLPPMAVQSRWHSEPVHLFTIDSNTFIKNQKGYPVLSKAHQALISRFMRLRTAPWILLCDVGPIPGVETDNASSLPGSEYPSLAQAAASIKKHHDPTPHLSYMRNLQSRQPPRTAIERFGTGYQDYLQAPLQPLTVNLESITYEVFEKDPIKYEWYERAIAKALSDWVEQKKPTSNPDGRVVVAVVGAGRGPLVTRALKASAQSGVEIDLWVVEKNPNAFVLLQRHNENLWGGKASLVHSDMRAWKGPRVRKSTTLSTEPVGQSLGIEGQFLYTPDPNQKTADSPSLDAIEFEDSKIDIVVSELLGSFGDNELSPECLDGVNHLLNPVHGISIPASYTAHLTPISAPKLHADVTNQSITNPAAPETPYVVMLHAIDYLSTNQSDASAGNPARSSVATVPYEPTTPFVQTAWSFSHPNRDIPPQPASTSMISNAHNVRRTRLTFPVPNRGVCHGLAGYFETVLYRDVELSTNPVTMDSKSANMISWFPIYFPLKTPLNVPDNGEIVATMYRQTDDRKVWYEWMVEVFALEGGSEPASASAPASERIAPVMSGARTISASADSAHNKDITADSYSRLAQKKARGPRRVRVGMSDLHSSIKDGCLM
Protein: At2g40630/T2P4.2 (Expressed protein) (Q94EI6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Histone-binding protein MSI1
- Transcription factor MYB3R-3
- Transcription factor-like protein DPB
- Transcription factor E2FB
- Transcription factor E2FC
- Retinoblastoma-related protein 1
- Transcription factor-like protein DPA
- Hydroxyproline-rich glycoprotein family protein
- Protein ALWAYS EARLY 2
- Integral membrane hemolysin-III-like protein
Sequence:
MEEQRGISSGVVSEPASNSVISGEKRNGNGLDEKDELGSKRVKVPDLASDAKTSSLQSHGNSNSVQQPNLSSEKLSKVSKVLVAPDAEGIRRVVRENDVLSKDIKPSSTVETRTYLPKAKSISTDDNRRVVNSGKQALLENHTVKTDDSKCRVVKNISLLKPRETTESVVSQRGAAEPSVSVPVGDKVSPFQMCSSADGSLGESDSMRRWREMKRNGFLSGPLGGVAAPTSTVVTTPVEVPAPKQQKNKRRGGESLKKKNDVPKKEQQLVDRFANVTAPSGLLTELNPGIINHVRTKKQVCSIIEALIRSSNDDATTRERHGDFNVRDAIREDRALAFKLPSTGVSDNAISITNPEQATSLAVEAATVASQWLEFLQQDLSGRLSAVQDSRNRVQNILTTELPLLASSRESSSNQANSLEMVTTNTSGDASSDKAATETHQKRWTAKFDQINKALYDEQRDLERSLNQVKEMQSRCNHGLRQMEEYSPFSSQSSDSSFGKDGNQETSMAVQAAAASIFSTCSFLLSMMKPPPTGS
Protein: Probable small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) (Q18786)
Organism: Caenorhabditis elegans
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P62316}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62316}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm6
- Probable small nuclear ribonucleoprotein-associated protein B
- Probable small nuclear ribonucleoprotein E
- Probable small nuclear ribonucleoprotein Sm D1
- Probable small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein Sm D3
- Probable small nuclear ribonucleoprotein G
- U1 small nuclear ribonucleoprotein 70 kDa
- U6 snRNA-associated Sm-like protein LSm5
Sequence:
MSAQAKPRSEMTAEELAAKEDEEFNVGPLSILTNSVKNNHQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKTGKGKKKAKSVAKDRFISKMFLRGDSVILVVKNPLAQAE
Protein: Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) (P54136)
Organism: Homo sapiens (Human)
Function: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:16055448, ECO:0000269|PubMed:16430231}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, cytoplasmic
- Glutamine--tRNA ligase
- Lysine--tRNA ligase
- Bifunctional glutamate/proline--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
- Aspartate--tRNA ligase, cytoplasmic
- Eukaryotic translation elongation factor 1 epsilon-1
Sequence:
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
Protein: Numb-like protein (A1L1I3)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Notch homolog 4, isoform CRA_b.
- Epidermal growth factor receptor pathway substrate 15
- E3 ubiquitin-protein ligase Mdm2
- E3 ubiquitin-protein ligase LNX
- Cadherin-1
- Dihydropyrimidinase-related protein 2
- E3 ubiquitin-protein ligase
Sequence:
MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL
Protein: Arginine kinase (Q9U420)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MATRDVAAELEKAFAKLQAAKDCQSLLKKYLTSDVFKKLKDKKTKLGATLLDVIQSGVQNLDSGVGLYAPDAEAYTVFADLFDPVIEDYQNGFKVTDKQPPKDFGDLNTLVDVDPEGKYVISTRVRCGRSLAGYPFNPCLTKEQYEEMESRVREQLSTMTDDLQGTYYPLSGMTKETQQQLIDDHFLFKEGDRFLQAAGACEYWPTGRGIYHNNDKTFLVWVNEEDHLRIISKQKGGNLKEVFGRLVKAVNIIEKKVEFSRDDRLGFLTFCPSNLGTTIRAIVHIKLPKLGADRAKLEEVAAKYNLQVRGTAGEHSDSPDGIYDISNKRRLGLSEYEAVKEMQDGILELIKLEKSK
Protein: Protein disulfide-isomerase (EC 5.3.4.1) (I3L3P5)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}. Melanosome {ECO:0000256|ARBA:ARBA00004223}.
Interaction partners:
Sequence:
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
Protein: Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Q5ZJJ2)
Organism: Gallus gallus (Chicken)
Function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P27694}. Nucleus, PML body {ECO:0000250|UniProtKB:P27694}.
Interaction partners:
- Replication protein A 14 kDa subunit
- DNA repair protein RAD52 homolog
- Uncharacterized protein.
- DNA topoisomerase
- RecQ-like DNA helicase BLM
- Replication factor A protein 2
- Fanconi anemia group M protein
- RecQ-mediated genome instability protein 1
- DNA-directed primase/polymerase protein
- Timeless circadian regulator.
Sequence:
MSVRLSEGAIAAIMQGENVYKPVLQVINTRAIATGNGPPRYRVLMSDGVNTLSSFMLATQLNPLVEEERLSAHCICQVNRFIVNSLKDGRRVVILMDLDVLKTADMVGGTVGNPVPYNEGQGQQRSSAPTANAAPNKPQQQDGNLSVAGSAAPKYHAPSNQFSKASAPSSVKTPGGTQSKVVPIASLNPYQSKWTICARVTQKGQIRTWSNSRGEGKLFSIELVDESGEIRATAFNDQADKFFPLIELNKVYYFTKGNLKTANKQYTAVKNDYEITFNNETSVVPCDDAQHLPSVQFDFVSISDLENTPKDSIVDVIGICKSYEDVTKIVVKASNREVSKRNVHLMDTSGKLVTATLWGNEAEKFDGSRQPVIAIKGARVSDFGGRSLSVLSSSTVVVNPDSPEAFKLRGWFDSEGQLLECASISDVRGGSASGVNTNWKTLYEAKSERLGQGDKADYFSCVGTIVHLRKENCMYQACPSQDCNKKVIDQQNGLYRCEKCDREFPNFKYRMMLLVTIADSLDYQWVTCFQESAEFILGQSATFLGELKDKNEQAFEEVFQNANFNTYEFKIRVKLETYNDESRIKATALDVKPVNYREYSKRLIASIRRNAQLG
Protein: Epididymis secretory protein Li 66 (V9HW69)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDWK
Protein: Complement component receptor 1-like protein (Complement regulatory protein Crry) (Protein p65) (Q64735)
Organism: Mus musculus (Mouse)
Function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Complement C4-B
- Complement C3
- Complement factor I
- CD59A glycoprotein
- CD59B glycoprotein
Sequence:
MEVSSRSSEPLDPVWLLVAFGRGGVKLEVLLLFLLPFTLGELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISGLIVGIFIGIIVFILVIIVFIWMILKYKKRNTTDEKYKEVGIHLNYKEDSCVRLQSLLTSQENSSTTSPARNSLTQEVS
Protein: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) (O77636)
Organism: Sus scrofa (Pig)
Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 10
- Neurogenic locus notch homolog protein 1
- Metalloproteinase inhibitor 3
- Neurogenic locus notch homolog protein 4
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Angiotensin-converting enzyme
- Arginase
- Transmembrane serine protease 2
- Tumor necrosis factor
Sequence:
MRQCALFLTSLVPIVLAPRPPDEPGFGSPQRLEKLDSLLSDYDILSLSSIRQHSVRKRDLQASTHLETLLTFSALNRHFKLYLTSSTERFSQNFKVVVVDGEDESEYPVKWQDFFSGHVVGEPDSRVLAHIGDDDITVRINTDGAEYNIEPLWRLINDTKDKRVLVYKSEDIKNVSRLQSPKVCGYIKADNEELLPKGLVDREPPDELVHRVKRRADPNPLRNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGERHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLRPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGRCKDGKCVPFCEREQRLESCACNETDHSCKVCCRAPSGRCLPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWEFIDKLSINTFGKFLADNIVGSVLVFSLMLWIPVSILVHCVDKKLDKQYESLSLLHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPLQPLQPGPVLPSAPSVPVAPKLDHQRMDTIQEDPSTDSHVDEDGFEKDPFPNSSAAAKSFEDLTDHPVTRSEKASSFKLQRQSRVDSKETEC
Protein: Carbohydrate metabolism regulator TYE7 (Q5AL36)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1.
Subcellular location: Nucleus.
Interaction partners:
- Uncharacterized protein
- Importin-95
Sequence:
MSSFQQENQLNANNNNNNVMNEYISYSVPLSPVTTNENPQDYWMNGLIANSVPISQTTSNSDINYSQPPNPINFNSIFEGVNIFSNDDFTSSSNDISLANSPETNATSDSIAQNLDEVKVKLENHNQARLDALEFAFETKSILKEQPKIKQEPGTKAATKPKRRAPRKKLTESQKKAHNKIEKRYRININAKIAGIQKIIPWVAFEKTAFETGEENETEAEAKNNTRLNKSMILEKATEYILHLQKKEEEYMAENQKLREQVIKLGGEI
Protein: Eukaryotic translation initiation factor 4E class II 2A (Eukaryotic translation initiation factor 4E family member 2) (Eukaryotic translation initiation factor 4E type 2) (Zgc:110542 protein) (A1L200)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Eukaryotic translation initiation factor 4 gamma, 3b.
- GRB10-interacting GYF protein 2
- Eukaryotic translation initiation factor 4E-binding protein 1
- Cytoplasmic FMR1-interacting protein
- non-specific serine/threonine protein kinase
- Cytoplasmic FMR1-interacting protein 1 homolog
- MAPK-interacting serine/threonine kinase 2a
- MAPK-interacting serine/threonine kinase 2b
- E3 ubiquitin-protein ligase ZNF598
- Eukaryotic translation initiation factor 4, gamma 2b.
Sequence:
MNNKFDALKDDDSGDHDQDNSSPKDGEKEKNDEEDKEANTTKRKAVVPGAGEHPLQYNYTFWYSRRTPGRPASTQSYEQNIKQIGSFASVEQFWRFYSHMIRPGDLTGHSDFHLFKEGIKPMWEDDANKSGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKAWEDFHGLVNASGGR