wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 473 (F1LTH0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Similar to U7 snRNA-associated Sm-like protein Lsm11
- U7 snRNA-associated Sm-like protein LSm10
- Eva-1 homolog B
- Histone RNA hairpin-binding protein
- Small nuclear ribonucleoprotein F
Sequence:
MERKEEELKRSHWNQAAMAEEFVTLKDVAMDFTLEDWEDLESELGQRDLFWDATLNNYQDLFSFTHPPQPSLIFQPDVREELEAIVRGGPEATSDEATEAKNPPLQSGFLEEDLSQIMEIFSTEELNFESCIGENWFDSFLGDPESLPRPDISNKESPTDRRCHESESGLSPGPPHCTREGAVMSDSPEKNLDPVILKESRSDLSQQDSVQGQEKLYKCSECGKSFSQSYHLIQHWVIHARGELPAWQEQPGALSKGALLLMQPGTQTSSESYVCQECGKSFSQNMYLQWHQKIHTGEKLCKTQSDNLEKPSKGPSDEPGKQLVSEAADSAKLCDSRGWDQEKPPTNKRHDREDLHKGQYGDSPSVLHPKPIKHQKTATRAKCFRCRRCGKTFSWAFHLADHQKVHTQRLYGCTSCPAVFNLRKHFFQHRKTHFAKTVFECQECRKLFNRRSSLIKHQAVHTGEKPYKCNECGKAFNHFSTLKIHQRIHSGEKPYTCSECGKTFSRRTALTEHHRVHSGFRPHQCPVCPRRFSRPSHLTRHQLSHAAERLFGCAKCKETFGHKEQLERHYKSHTIECSYECKQCGEHFICSSTLNCHLSIHIRENTSEKVSGQHSQHTEKCFKNTKCGKAFNHSKYPEQHEKIHAKVASCEQSPCRNTCDQSMQPIHCQSSCAAVKPNKCTEPEKCIRNTSVSQHQPSQSEPPFKCNTCNRTFKQSAHLSNHQLIHTTEKPFKCKECDRAFKHSNYLIQHQKIHSVKDFECSECGKKFHQKSCLSKHQKIHSGQKPFKCADCGKAFIFSAQLIRHQRIHTGEKPYVCQECGKAFSQSSCLTLHLRTHTGEKPYTCSTCGKAFSQKANQRKHERTHSGEKPCACDVCGKSFGFSTHLRQHQRIHTKEKPRCQDCHKAFHSFSALSEHQKLHTCTAASTTAQSHLLTAEARASEGPHLEPAIETSTLQTSPPHSPNKNQ
Protein: Protein HEXIM1 (A5D8S8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O94992}. Cytoplasm {ECO:0000250|UniProtKB:O94992}. Note=Binds alpha-importin and is mostly nuclear. {ECO:0000250|UniProtKB:O94992}.
Interaction partners:
- La-related protein 7
- 7SK snRNA methylphosphate capping enzyme
- Cyclin-dependent kinase 9
- Cyclin T1
- Si:ch1073-157b13.1.
- Cyclin T2
- Cyclin-T2b
- Bromodomain-containing protein 4
- TEF transcription factor, PAR bZIP family member b.
Sequence:
MELIKEETAPEDDSRGRQRDCRTSVVSSKQVQRNQLEICPGLVSGDVHPMCRDRSDPEPRTGDAASDDGFPADKTSSKRDSECAAVNTDGVSDGRQGKKKHRRRPSKKKRRWKPYFKLTWEEKKELDERETARASRVRAEMFAKGLPVAPYNTTQFLMEEHDREEPDLNTELGGRKSGAIRSEDTASEDENFEAEEDDEEEGGGGSDGMGRPGQAGGEFLQKDFSETYEKYHVEALQNMSKQELVREYLELEKCMSRLEEENNWLRHVRRNPESPADGTGSQRVRELEVEVEKLRAENNELLLKTPASNEPGLNQSQPS
Protein: LDL receptor related protein 8 (A0A8I6GH61)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISSYDRPLWAEPCLGETRDLEDPAPAHKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP
Protein: Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein) (Q6DJT9)
Organism: Homo sapiens (Human)
Function: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Subcellular location: Nucleus {ECO:0000269|PubMed:10646861, ECO:0000269|PubMed:11882654, ECO:0000269|PubMed:16207715}. Note=Strong nucleolar localization when sumoylation is inhibited.
Interaction partners:
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
- Transcription elongation factor A protein 1
- High mobility group AT-hook 2
- Catenin beta-1
- Transcription elongation factor A protein 2
- Transcription elongation factor A protein 3
- Insulin-like growth factor 2
- Cytochrome P450 4F8
- Ligand-dependent nuclear receptor corepressor-like protein
Sequence:
MATVIPGDLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCIQQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCDRRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNVSVPIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQSSGSAHQMITTLPLGMTCPIDMDTVHPSHHLSFKYPFSSTSYAISIPEKEQPLKGEIESYLMELQGGVPSSSQDSQASSSSKLGLDPQIGSLDDGAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQEEAHSSVSQLPPQTQDLQDPANTIGLGSLHSLSAAFTSSLSTSTTLPRFHQAFQ
Protein: Two-component response regulator (Q948L2)
Organism: Zea mays (Maize)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036392}.
Interaction partners:
Sequence:
MAAAEARGGEFPVGMKVLVVDDDPTCLVVLKRMLLECRYDVTTCPQATRALTMLRENRRGFDVIISDVHMPDMDGFRLLELVGLEMDLPVIMMSADSRTDIVMNGVKHGACDYLIKPVRMEELKNIWQHVIRKKFNENKDHEHSGSLDDTDRNRPTNNDNEYASSANDGGDGSWKSQRKKREKEDDETDLENGDPSSTSKKPRVVWSVELHQQFVNAVNHLGIDKAVPKKILELMNVPGLTRENVASHLQKFRLYLKRIAQHHAGIPHPFVAPVSSANVAPLGGLEFQALAASGQIPPQALAALQDELLGRPTSSLALPGRDQSSLRVAATKGNKHHEEREIAFGQPIYKCQNNAYGAFPQSSPAVGGLQPFAAWPNNKVGMPDSTSTLGNVGNSQNSNMLLHELQQQPDTLLLGTLHNIDAKPSGVVMSSQSLNTFPASEGISPNQNPLIIPSQPPSFVSSIPPSMKHESLLGLPSTSTSLLGGLDMVNQASTSQALISSHGTNLPGLMNRSSNAIPSPGISNFQSGNIHYVVNQNAMGVSSRPPGVLKTESTDSLSCSYGYIGGSTSVDSGLFSSQSKNPQYGLLQNQNDVNGSWSPSQDFDSFGNSLGQGHPGTTSSNFQSSALGKLPDQGRGRNHGFVGKGTCIPSRFAVDEVESPTNNLSHSIGNSGDIVNPDIFGFSGHM
Protein: ABC-type transporter, periplasmic component (Q8NSE9)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- ABC-type transporter, permease components
- ABC-type transporter, permease components
- ABC-type transporter, permease components
- Trehalose import ATP-binding protein SugC
- ABC-type transporter, permease components
- Trehalose import ATP-binding protein SugC
- Trehalose import ATP-binding protein SugC
- ABC-type transporter, permease components
- Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein
Sequence:
MSSISRKTGASLAATTLLAAIALAGCSSDSSSDSTDSTASEGADSRGPITFAMGKNDTDKVIPIIDRWNEAHPDEQVTLNELAGEADAQRETLVQSLQAGNSDYDVMALDVIWTADFAANQWLAPLEGDLEVDTSGLLQSTVDSATYNGTLYALPQNTNGQLLFRNTEIIPEAPANWADLVESCTLAEEAGVDCLTTQLKQYEGLSVNTIGFIEGWGGSVLDDDGNVTVDSDDAKAGLQALVDGFDDGTISKASLAATEEETNLAFTEGQTAYAINWPYMYTNSEEAEATAGKFEVQPLVGKDGVGVSTLGGYNNGINVNSENKATARDFIEFIINEENQTWFADNSFPPVLASIYDDESLVEQYPYLPALKESLENAAPRPVSPFYPAISKAIQDNAYAALNGNVDVDQATTDMKAAIENASS
Protein: Complement factor H-related protein (Q61407)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGFCNMLLLSNILLTAWLSTAKGEEKTCSPPYILNGIYTPHRIIHRSDDEIRYECNYGFYPVTGSTVSKCTPTGWIPVPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYRCDNGFSPPSGYSWDYLRCTAQGWEPEVPCVRKCVFHYVENGDSAYWEKIYVQGQSLKVQCYNGYSLQNGQDIMTCTENGWSPPPKCIRIKTCSASDIHIDNGFLSESSYIYALNRETSYRCKQGYVTNTGEISGSITCLQNGWSPQPSCIKSCDMPVFENSITKNTRTWFKLNDKLDYECLVGFENEYKHTKGSITCTYYGWSDTPSCYDSTRTCGPPPPIDNGDITSLSLPEYEPLSSVDYQCQKYYLLKGNKTITCRNGKWSEPPTCLHACVIPENIMEAHNIILKWRHTEKIYAHSGEDIEFECKRGYQKARGSLPFRTKCINGTINYPTCV
Protein: Cnx (Q24097)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
ELEQLKAFNDKTPYTIMFGPDKCGNDVKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPIDSFEIRVDHKIINEGSLLTDFKPPVNPPAEIDDPNDLKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPNYQGKWAPRKIPNPDFFEDLKPSNDAISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIVVNRTHS
Protein: Protein UL88 (F5H9F9)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in incorporating a subset of tegument proteins into the virion.
Subcellular location: Virion {ECO:0000250|UniProtKB:P16731}. Virion tegument {ECO:0000250|UniProtKB:P16731}. Host cytoplasm {ECO:0000250|UniProtKB:P16731}. Note=Accumulates in a juxtanuclear location reminiscent of the viral cytoplasmic assembly compartment. {ECO:0000250|UniProtKB:P16731}.
Interaction partners:
Sequence:
MMEAAAAAAAAFRPEERPTPGWHDAALLMDDGTVREHAFRNGPLSQLIRRVLPPPPDAEDDVVFASELCFYCSGRFNRRSSVFSIYWQKHSDLVYALTGITHCAKLVVECGQLGSSRLRWRDGDASGEERRGDDDSRDELYDVPGIYMIRVNDGGSTGPRHVIWPGTSVLWAPDVVITTVQRRISAARALVNTFRQYFFLLERRSHEELVLCPPEMEERLAPLLQSATRGDSDMFDGVVASAYHRLRMSNIPRSSARLLEHCVGLAGAKKLLLLDVPRLENYFLCQVCLYELDEDEMGEEMLGMLAGKPEDAAVSGASGGFLLHRKTMKLAACLCLLLNSLHLHQEALEALDPPPPRVEENDLVNVVLRRYYRSHGGVQARTLAAARALLADYAETFSPLGSFTRLGYDRLVSADAGVSRRHLVALLRA
Protein: Prokineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine) (P58294)
Organism: Homo sapiens (Human)
Function: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
Subcellular location: Secreted.
Interaction partners:
- Prokineticin receptor 1
- Prokineticin receptor 2
- Colipase
- Adenylate cyclase type 3
- Delta-1-pyrroline-5-carboxylate synthase
- G-protein coupled receptor 83
Sequence:
MRGATRVSIMLLLVTVSDCAVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF
Protein: Ras-interacting protein 1 (Rain) (Q5U651)
Organism: Homo sapiens (Human)
Function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15031288}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15031288}. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
Interaction partners:
- Rho GTPase-activating protein 29
- Ras-related protein Rap-1b
- Alpha-2-macroglobulin receptor-associated protein
- Krev interaction trapped protein 1
- Ras-related protein R-Ras2
Sequence:
MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPLPPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWASEKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEALERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQELWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASPGPGTGSGAPAGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGTADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSPAPYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVATSP
Protein: Nucleoporin NUP85 (Nuclear pore protein NUP85) (P46673)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Interaction partners:
- Nucleoporin NUP159
- Nucleoporin SEH1
- Nucleoporin NUP120
- Nucleoporin NUP133
- Protein transport protein SEC13
- Nucleoporin NUP192
- Nucleoporin NIC96
- Nucleoporin NUP145
- Nucleoporin NUP84
- Nucleoporin NUP157
Sequence:
MTIDDSNRLLMDVDQFDFLDDGTAQLSNNKTDEEEQLYKRDPVSGAILVPMTVNDQPIEKNGDKMPLKFKLGPLSYQNMAFITAKDKYKLYPVRIPRLDTSKEFSAYVSGLFEIYRDLGDDRVFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEVFIGRVKDQDGRVNRFYELEESLTVLNCLRTMYFILDGQDVEENRSEFIESLLNWINRSDGEPDEEYIEQVFSVKDSTAGKKVFETQYFWKLLNQLVLRGLLSQAIGCIERSDLLPYLSDTCAVSFDAVSDSIELLKQYPKDSSSTFREWKNLVLKLSQAFGSSATDISGELRDYIEDFLLVIGGNQRKILQYSRTWYESFCGFLLYYIPSLELSAEYLQMSLEANVVDITNDWEQPCVDIISGKIHSILPVMESLDSCTAAFTAMICEAKGLIENIFEGEKNSDDYSNEDNEMLEDLFSYRNGMASYMLNSFAFELCSLGDKELWPVAIGLIALSATGTRSAKKMVIAELLPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSRAGKYELVKSYSWLLFEASCMEGQKLDDPVLNAIVSKNSPAEDDVIIPQDILDCVVTNSMRQTLAPYAVLSQFYELRDREDWGQALRLLLLLIEFPYLPKHYLVLLVAKFLYPIFLLDDKKLMDEDSVATVIEVIETKWDDADEKSSNLYETIIEADKSLPSSMATLLKNLRKKLNFKLCQAFM
Protein: Microtubule nucleation factor SSNA1 (Sjoegren syndrome nuclear autoantigen 1 homolog) (Q9JJ94)
Organism: Mus musculus (Mouse)
Function: Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (By similarity). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching. Required for cell division (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:O43805}. Midbody {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O43805}. Cell projection, axon {ECO:0000269|PubMed:30250060}. Note=In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (By similarity). Localizes to axon branching points in neurons (PubMed:30250060). {ECO:0000250|UniProtKB:O43805, ECO:0000269|PubMed:30250060}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- DNA-directed RNA polymerase II subunit RPB11
Sequence:
MTQQGAALQNYNNELVKCIEELCQKREELCRQIQQEEDEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATASDQKSSGGKDS
Protein: Interferon lambda receptor 1 (E7F976)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cytokine receptor family member b4.
- Cytokine receptor family member B16
- Cytokine receptor family member B12
- Interleukin 10 receptor, beta.
- Helicase ATP-binding domain-containing protein.
- FA complementation group M.
- Interleukin 10 receptor, alpha.
Sequence:
MCPLGTAMFLLCCVGCWCQNCNLTKPYFKSQNFFSVLHWDPVDLPGQTALYSVQYSPYGSPRQLVPWCQNISSPVCDLTDVMSAVVTEVTITYKAIVYAGAQCLGEVRFSPFKETTLAAPQLTVTSNQTHLNVTLSKPRVPWNRSIESIKYWADYRDVKRYPVKYIVRLTHPGSQEYFSRTSPSVLIELLWKDVEYCGEVFYSLTHPGWFRPSENTTFCLTVSAPNPLLHILMWPSVLAALLMVFLSVMLCHRFVKRKRSLPKALMLPENNTPPFWSDPKDNISKVEMWSGMFFGMKPDPQTPSLTPQKSEITVKDNAYASQEPYRCQQDGQIQNSREPSENYSLCLPAQMPKESFNSSDSFSPESESPKMIHSDTSESLNNSDTFTPKSDSVKLIQSDANESFNNSESLSSDSDLVELIHLDTNESFSSSDSFIPVTDSVEFIHSDAECKTLVVPARPDKNGALQFHELFFQDESFPDESAERMPLLTDLIQSDSSYLPGQVPNVVTSNYKQNWVPGLLLEGQEDKRTYIMRTEKTEDMPEAEEDFRESEESRIGVVFLDRCLLEIQGLSLS
Protein: F-actin-capping protein subunit beta (Q7SXP1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU365078}.
Interaction partners:
- F-actin-capping protein subunit alpha
- F-actin-capping protein subunit alpha
- Dynactin subunit 2
- Dynactin 4.
- Dynactin 3
- WD repeat domain 1.
- Actin-related protein 10
- Dynactin 5.
- Dynactin 1a.
- Zgc:112496.
Sequence:
MNEQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYEPPIDDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTTKTGSGTMNLGGSLTRQMEKDETVSESSPHIANIGRLVEEMENKIRSTLNEIYFGKTKDIVNGLRSVQPLADKTKQEALKNDLIQALSQRKQQS
Protein: Glutathione S-transferase L3 (AtGSTL3) (EC 2.5.1.18) (GST class-lambda member 3) (Q9LZ06)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase Z2
- Glutathione S-transferase U25
- Glutathione S-transferase T1
- Glutathione S-transferase F9
- Glutathione hydrolase 3
- Putative inactive glutathione hydrolase 4
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Glutathione synthetase, chloroplastic
- Probable glutathione peroxidase 3, mitochondrial
- Probable glutathione peroxidase 2
Sequence:
MAPSFIFVEDRPAPLDATSDPPSLFDGTTRLYTSYVCPFAQRVWITRNFKGLQEKIKLVPLDLGNRPAWYKEKVYPENKVPALEHNGKIIGESLDLIKYLDNTFEGPSLYPEDHAKREFGDELLKYTDTFVKTMYVSLKGDPSKETAPVLDYLENALYKFDDGPFFLGQLSLVDIAYIPFIERFQTVLNELFKCDITAERPKLSAWIEEINKSDGYAQTKMDPKEIVEVFKKKFM
Protein: Tousled-like kinase, isoform C (EC 2.7.11.1) (Q8IRT7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCVQKNMRRLKKMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS
Protein: Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) (Q63415)
Organism: Rattus norvegicus (Rat)
Function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
Interaction partners:
Sequence:
MPPRAPPAPGPRPPPRAAGRHGLSPLAPRPWRWLLLLALPAVCSALPPPRPVYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCADKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHMCVATADKRPRSIPVVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHPYRTFSSHQSRSRMLELSVPEQEPLKAEGPPPQAETPEEEEEYTGVCHPECGDKGCDGPSADQCLNCVHFSLGNSKTNRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCVDEPEKSTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRNCSRCKAGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
Protein: At5g11730 (Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein) (Glycosyltransferase) (Q9LYF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Alpha-
- Probable xyloglucan galactosyltransferase GT14
- Rhamnogalacturonan I rhamnosyltransferase 1
Sequence:
MQNRIVQLEEGKENGITVRSGHYKGFPSKLLLLLGLFLTFSVTVFIISVSTIKYTGIQSVVTTVTSSFVPCREGEPNSLSKWIQPPAVLMHNMSDEELLWRASFWPRRKEYPFKRVPKVAFMFLTKGPLPLASLWERFLKGHKGLYSVYLHPHPSFTAKFPASSVFHRRQIPSQVAEWGRMSMCDAEKRLLANALLDVSNEWFVLVSESCIPLYNFTTIYSYLSRSKHSFMGAFDDPGPFGRGRYNGNMEPEVPLTKWRKGSQWFEVNRDLAATIVKDTLYYPKFKEFCRPACYVDEHYFPTMLTIEKPTVLANRSLTWVDWSRGGPHPATFGRSDITENFFGKIFDGRNCSYNGRNTSMCYLFARKFAPSALEPLLHIAPKILGF