wanglab/gogpt-training-data huggingface dataset:
Protein: Metal regulatory transcription factor 1 isoform X1 (Metal-regulatory transcription factor 1) (A0A0G2KFP7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTGASIYRRNKSTHVDTNPGLSFSVRIMGENGPLSETAMLFEDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSSHPLSEDANHSLCLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQTAPADASTHPAFPQPPPSTCSSSCSITAPAQDAQTPPTTQQAPPPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAPSATQHYMMAQPVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAPPTISIAPTLGLQPSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSGNAVQQIGLSLPVIIIKQEESCQCHCACRDSAKDKSTSSSQDKTKNTSPPPPPAPPPPPPALPKEPPSCCPSKPHTQPQQDLPTAPLTPNPPTDALGSMDVSDLLSPETTANIEALLMVADGFSMADGGGSGAP
Protein: Stathmin-3 (SCG10-like protein) (Q9NZ72)
Organism: Homo sapiens (Human)
Function: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:21471001}. Cell projection, growth cone {ECO:0000269|PubMed:21471001}. Cell projection, axon {ECO:0000269|PubMed:21471001}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHU6}.
Interaction partners:
Sequence:
MASTISAYKEKMKELSVLSLICSCFYTQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPMLSSPPKKKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSRQAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG
Protein: Cytoplasmic dynein 2 light intermediate chain 1 (Q381A5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|ARBA:ARBA00004430}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
- Intraflagellar transport protein 80
- Intraflagellar transport protein 57/55
- Intraflagellar transport protein IFT88, putative
- Intraflagellar transport protein 56 homolog
- Intraflagellar transport protein component, putative
- IFT80/172/WDR35 TPR domain-containing protein
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
- Uncharacterized protein
- Intraflagellar transport protein 140
Sequence:
MSMQGGAAGGAARTEVPPPPAPNGMPPDAGAADGKPPPAADVAPADSAAPPAPAAPQIVVDPTKDLWQNIALNTKENNLPQSEANLFVVGCSGAGKTSVIQRVCSAIGAGGNTSGKGKTKVKPTTALDYQYTTRSDRHVSQTVHFWELAQGMELSQLCEVVITPENVHLMHIAIVVDFSDPSSMWDTLAYWLKRVDRRANEILQKMRAKGSNTPDKLHARAQRALGEGHPDLKRVRLSGLPTVIVCNKVDAFPGPMEQMKTLTRCLRFIAHLYGAYLVFSSDADSAKLRLLLNHLLFLTPFDARQVELDVERGTILIMPENDTFVDIGDPPLCDGPSGGPVTQSTGDSELDRWKVPLDAMFPPKAGGGRAQSDAMLKRLYDMGEGGFGEPTIDTIRRQKDEELEQYRKSAARRDKGDK
Protein: SPG11 vesicle trafficking associated, spatacsin (D3Z9Z3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAKPGPGSAASPGCAGAMERVLPMLLVRIPAEETAQLGPRAQLHRELEALGSLTAAGSLQVLSLAPGSRGGSSCRLQGPFRQFLWEESQNSTSADKPRVLVAREDCGLLIYEFDLRDGRCDAALLHSCCGRTLQKLTEDQGVSISFKSLRILSFDNSTSLLLINECLVVRVVFPGRESGIGVLGCLSLPLPAQAVDTIIDVQLCKRFLFLLSTLGWIHIFDTVKGMHVARVDLALPREDSEQQEPASISSFMSLKVSRDLDVLLLVSSSSTAVALNLHLYFRLHPGHLLCEGTLQDLPIEGPTGIDEDDLVNSAHNMKLTKVSFQVDRSWRAQLASLNESVRSSEPELSCYPPWFQGALCLESLESGNHSPIVPNHVFIPGDVPSGQYAFPQKEHSKTSEPRPWRTMHLSEQEQPTELTCLSVTGFTALFIQAVGTTSCTVVLWDLETQSMQCFSLSQKCTPVDISGDQQLCLALTENGLSLILFGLTQEEFLNRLMIHGSASTVDSLCHLNGWGRCSIPIHALEAGIENRQLDTVDFFLKSKENLLTPSSKSPAPDQQQHFSSQLYLRQVEEMTPALDLLCSAIRESDSETQSKHFAEQLLHLTLSFLNKQMRELFDHTEELDEHLQKGAAILTSYINELRTFMIKFPWKPGDAIDESDENEEVLTVKEGQVWEELRSEEVIADAILNNRIPEAQTFFRITGHSAQRLEELVRIGLDLAFDSLKKNSVEEASRLLRNMGFSVEDELLKISFYTTDKNIRDFLVEILKEKECFSEKERRTVDFVHQAERLYSGHFQENAPMQAFPRYWIKEQDCFKHKSVLDTFLKCDTKDEFTKQDHRIALNWAHWWDRQTQECILLPRISSEEYKAHSPEALWRHLTARHDWSSISLWMEEFQAQETVSPQQSKWPPLSAAVIEQNTCCSRHMRNAILDQLARCGIFLASELEDFELLLLRLSRIGGVMQDALPVQSYRSSAGCNFDSQVILYCLEHGLQHLLYVYLDYYKLSPGNCPFLEKKELHEAHPWLEFLVQCRQVSSNLTDPKLIFQASLANAQISIPTNQASVSSMLLEGHTLLALATTMYAPGGVSQVIQHEDSENCLKKVDPQLLKMALTPYPKLKAALFPQCTAPSILPSDITLYHLIQSLPPFDPSRLFGWQSANTLAIGDAAGQLPHFSSPDLVSKYAVVEQLSYTYYLHHGRPSFAFGTFLVQELIKSKTPKQLIQQVGKEAYTLGLSSFHNPSVGAACVCFLELLGLSSLKLRVDLKMANVVLGSRRRNEDAHPSFIRESLAEKLSKLADGDRATTEELLVLLEEGVWDSIEQQGFNRLSSESSSQWSLVLQFCMLHDMKLSVSYLRECAKANDWLQFLVHSQLHNYHPEEVETLLQYFSPVLQSHLKLASEKLSSGSISKDDSCLQELQKNKETSDFFEILHRCSDESASWCWLLAEAVRHRVPILSVLASCIQGASAVPCLCVWIVTSVEDKVAAEAIEHIQISVEDHHWSLEDLSIIWRTVLTRRKIHTLIRGFRLFIKDSPLLLIMEMYELCVFFKNYGKAKVKLVEFQKSLEMLDTVATRVLPVIPATWMREQVCFLLKLMPQQCETQYELQKVLQLFVGMEQLFSDGPDVQKLYRLSQVLKDTPITISPAVISSYSTESLQRECRSILEKLKADGQFAVARRVAELASLPVDGLVIEQLTQEMQMLTHTQQWSLKQARLDFWRKCHENFKKNSVSNRAASSFFSSQAPEASEHPAEQGSLEERHLLLTLAGHWLAQEEPVPVEELEELEKQIWLCRIAQHTCGGAEEETKPSLSQHKLAPAELSSDSSASEFSFSKLAALNTSKYLDLNGLPSKEMCENTLEHREQESLNTLIGQLLDGGCVHEASRVCRYFRVYSQDLVLLLHCRALASAEASMEDLHSEIRALLSNATLPEDLESPGVPLRKVHSREKQPFNLAEESQTFLQLTALCQDRTLVGMKLLDKIPSVPHGELSCTTELLILAHHCFTCACYMEGIIRVLQAARMLTDNHLAPNEEYGLVVRLLTGIGRYNEMTYIFDLLHQKHYFEVLMRKKLDPTGTLKTALLDYIKRCHPGDSEKHNMIALCFSMCREIGENHEAAACIQLKLIESQPWEESLKDGAQLKQLLLKALTLMLDAAESYAKDSCVRQALHCNRLTKLITLQIHFLNSGQNTMLINLGHQKLMDCIMTLPRFYQASIVAEAYDFVPDWAEVLYQQVILKGDFSYLEEFKQQKLLKPNIFEDISKKYKQHQPTDRVTENLKKLLSYCEDIYLYYKLAYEHKFFEIVNMLLKDPQTGCCLKDMLAG
Protein: Protein DAMAGED DNA-BINDING 2 (UV-damaged DNA-binding protein 2) (Q6NQ88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity). Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Involved in UV-B tolerance and genome integrity. In association with ATCSA-1, is necessary for repair of UV-B-induced DNA lesions.
Subcellular location: Nucleus {ECO:0000269|PubMed:18551167}. Note=Broadly distributed over chromatin.
Interaction partners:
- DNA damage-binding protein 1a
- Cullin-4
- DNA damage-binding protein 1b
- WD repeat-containing protein ATCSA-1
- Light-mediated development protein DET1
- RING-box protein 1a
- DNA repair protein RAD4
- Transducin/WD40 repeat-like superfamily protein
- E3 ubiquitin-protein ligase COP1
- Protein ALTERED SEED GERMINATION 2
Sequence:
MSSTRSRRKRDPEIVIARDTDSELSSSEEEEEEEDNYPFSESEEEDEAVKNGGKIELEKNKAKGKAPITVKLIKKVCKVCKQPGHEAGFKGATYIDCPMKPCFLCKMPGHTTMSCPHRVVTDHGILPTSHRNTKNPIDFVFKRQLQPRIPPIKPKYVIPDQVHCAVIRYHSRRVTCLEFHPTKNNILLSGDKKGQIGVWDFGKVYEKNVYGNIHSVQVNNMRFSPTNDDMVYSASSDGTIGYTDLETGTSSTLLNLNPDGWQGANSWKMLYGMDINSEKGVVLAADNFGFLHMIDHRTNNSTGEPILIHKQGSKVCGLDCNPVQPELLLSCGNDHFARIWDMRKLQPKASLHDLAHKRVVNSAYFSPSSGTKILTTCQDNRIRIWDSIFGNLDLPSREIVHSNDFNRHLTPFKAEWDPKDTSESLIVIGRYISENYNGTALHPIDFIDASNGQLVAEVMDPNITTITPVNKLHPRDDVLASGSSRSLFIWRPQDNTEMVEEKKDKKIIICYGDSKKKGKKQKRGSDDEDDEDDIFSSKGKNIKVNKYQAKTTKKTKT
Protein: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) (P37238)
Organism: Mus musculus (Mouse)
Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:20498072, ECO:0000269|PubMed:23525231}. Cytoplasm {ECO:0000250}. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner (By similarity). NOCT enhances its nuclear translocation. {ECO:0000250}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear receptor corepressor 2
- Retinoic acid receptor RXR-alpha
- Nuclear receptor coactivator 1
- NAD-dependent protein deacetylase sirtuin-1
- Nuclear receptor corepressor 1
- Histone-lysine N-methyltransferase PRDM16
- Mediator of RNA polymerase II transcription subunit 1
- Histone lysine acetyltransferase CREBBP
- Nuclear receptor coactivator 2
Sequence:
MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
Protein: Transcription initiation factor TFIID subunit 10 (TBP-associated factor 10) (O60171)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex subunit Spt7
- SAGA complex/transcription factor TFIID complex subunit Taf6
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 2
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 11
- Histone acetyltransferase gcn5
- SAGA complex/transcription factor TFIID complex subunit Taf5
- Transcription initiation factor TFIID subunit 8
Sequence:
MSDINNNEPAENIEQPKQEPEDGNNSMSVDEQPETSSTNLPTGDNLAPMSVESPAHLNNEDSPKSDDSRERHGSNYVIEPHLELRDMAKDKTLENFLAQMDDYSPLIPDVLLDYYLSLSGFKCVDPRLKKLLGLTAQKFISDVAQDAYQYSKIRTGSSNASSTTFGAQNFGAGGASGIGSSGRRGDRGKTVLTVDDLSAALNEYGINLKRPDFFR
Protein: Protein TIFY 3A (Jasmonate ZIM domain-containing protein 11) (Q9M246)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Repressor of jasmonate (JA) responses. Targets MYC2, MYC3 and MYC4 that are JA-dependent transcription activators.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Transcription factor MYC2
- Coronatine-insensitive protein 1
- Transcription factor MYB24
- Transcription factor MYB21
- Transcription factor MYC3
- Protein TIFY 6A
- Protein TIFY 6B
- Protein TIFY 7
- Protein TIFY 5A
- Protein TIFY 5B
Sequence:
MAEVNGDFPVPSFADGTGSVSAGLDLLVERSIHEARSTEPDASTQLTIIFGGSCRVFNGVPAQKVQEIIRIAFAGKQTKNVTGINPALNRALSFSTVADLPIARRRSLQRFLEKRRDRSTKPDGSMILPSQLTIIFGGSFSVFDGIPAEKVQEILHIAAAAKATETINLTSINPALKRAISFSNASTVACVSTADVPIARRRSLQRFFEKRRHRFVHTKPYSATTSEADKNETSPIVT
Protein: Phosphoinositide 3-kinase (Q7JNX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSNQAHIDYDKQFQDDLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAAQRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFGKLIEDLQRMQPTNPQSALVPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPYTAPIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEANGVAFPARRQVPSTVGVSSSSHTGNNGHSSVPRRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVQIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGELLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMETLEYRMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVSRN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (H7BXZ5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
XSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIEKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT
Protein: Forkhead activin signal transducer 3 (Fast-3) (xFAST-3) (Forkhead box protein H1b) (XFoxH1b) (Q8JIT7)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional activator. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 2 (ARF2), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much higher affinity than foxh1/fast-1. Acts with foxh1/fast-1 to control the convergent extension movements of gastrulation.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MSFGLHPWDVAFRPSPPHNLEKKVVPPGADREKSLPSPKEDSDGAREPDSTVDLRKKNKKKKNYQRYAKPPYSYLAMISLVIQNSPEKRLKLSQILQDISSLFPFFKGNYQGWKDSIRHNLSSNDCFRKVLKDPLKPQAKGNYWTVDVTRIPPDALKLQNTAVTRQDLFPLDLAPYILHGQPYRSLERLSANHTRGRTTPRMEPEVQIPVSDPAVSFPMILWNLPTSYSKCVAPNVVAPPSIHPLLLYSNFPSISIYNYLPPPYGSPVYSDRRDLLASGLHPQIPLTPKPPELKNAPSDFPPNKTVFDIPVYTGHPGFLASQSLFSPHLPTATPPLVGYRPSGL
Protein: Acyl carrier protein 4 (F4JRT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASLSTTSLSFKAPSTTISQVLRKASSSQSVTFGRFTSSTKSLRLQISCAAKAETVQKVSDIVKEQLALAADVPLTAESKFSALGADSLDTVCYTLSVSYHCHVEIVMALEEKFNISVEESDAQNITTIQEAADLIEDLVQKKPAAETS
Protein: Fatty acid synthase (EC 1.1.1.100) (EC 1.3.1.39) (EC 2.3.1.41) (EC 2.3.1.85) (EC 3.1.2.14) (B7Z001)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Acetyl-CoA carboxylase, isoform A
- long-chain-fatty-acid--CoA ligase
- ATP-citrate synthase
- Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial
- Long-chain-fatty-acid--CoA ligase
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- 3-oxoacyl-[acyl-carrier-protein] synthase
- Very long-chain-fatty-acid--CoA ligase bubblegum
- Long-chain-fatty-acid--CoA ligase heimdall
- RH09070p)
Sequence:
MPLQLNLLQAVDQPHPVAFKPNNCSTHQPQHSPSTQNNGKSARANRRRRRRRNKQQQNSQQPDAFRDTDAQLTPSTSSSTPHSAPNDRQDHLNSQFNPESINMPARFAEEVITAEPAQRAAPQLDLGGGHYVPRQQHLNDEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQFFGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNGYGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKPTMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQGITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGSVKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIGLNSFGFGGANAHVILKSNPKPKALTPKDGALKVVLASGRTFEAVEQLLESASTNADDDEYLQLINEIHSKAIPNHFFRGYGVVSSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKDLMKIEAFAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIVGHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCFPVCHNSEDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAKNRTARWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQAILKRALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWDHTQKWLVAKFGKETSSGETIVEVDLSKEDDAFLAGHTIDGRILFPATGYMTLAWQTFAKMQGSEFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKITIPESIDNEELPLEEQTPSAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQWVDNWISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDINVIKSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENSEKARLHALDVAIQVIIENSSGAVKLKGVELANGRNPDVLVANRLLQIIEGEPVLTGDVAVVTSNNNEETITAALGDSGVRVVSKDVLKEPVEQNCHFVFGIDVLSRPDTKTLENSIASIRENGFLILEETLPTYTKTGRALLTKFGFVAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGEELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLYRQQLEKDLISNVLKNGAWGTFRHLKLETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAPINFRDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGRFLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSVFNDQQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIPRTYMHPEKSYILVGGLGGFGLELTNWLVTRGARYIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSNKLALVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGNIGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPSCLQTIDLFLQQPHPVVASMVVAEKRKSDQSAGVSLIATIANILGLRDTKNIQDGASLADLGMDSLMSAEIKQTLERNFDIVLSAQEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEANITSGGSSRTASPMGDGTQVVFTTSLIPTEAIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAKRLEVPAYGLQYTEAVPSDSLESAAKFFIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETNEVANVIMLDGAPSYVNWYTSSFKQRYTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVIPTWEEKLERFAELMSNEITQPVETIKKSATLFYKKLELADGYQPTLKLKTNVTLVKPTDNSAKLDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTIQSILKRLFN
Protein: Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (P21278)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P29992}; Lipid-anchor {ECO:0000250|UniProtKB:P29992}. Cytoplasm {ECO:0000250|UniProtKB:P29992}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Extracellular calcium-sensing receptor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Endothelin-1 receptor
- Cholecystokinin receptor type A
- Endothelin receptor type B
- C-C chemokine receptor type 5
Sequence:
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMVRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV