wanglab/gogpt-training-data huggingface dataset:
Protein: HORMA domain-containing protein (Q20305)
Organism: Caenorhabditis elegans
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- HORMA domain-containing protein
- HORMA domain-containing protein
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Synaptonemal complex protein 3
- Long arms of the bivalent protein 1
- Meiotic recombination protein spo-11
- DNA repair protein RAD51 homolog
- Sun domain-containing protein 1
- Meiotic recombination protein rec-8
- C2H2-type domain-containing protein
Sequence:
MAPLETIYDESLNKSADSIDDKKWSKLFPRIVSDPDRSSNFMTRAIYVAFSAVLRNRNILGQEYFTKNYITEKLKCMTLCFRNPRSNQIAQLLRNAGDATKDGFLKEVSLVITNNEGDLEAIEVFSMKFIYFENGGVVARLSTDKNGQEDPHFAKLAQLVYEGGDSVRDQMVTIVRSVQFLCTKVLEPLPEEFTANFRLEYTNDAPSNFRIDGFEDSSTFYTLPDDIQSATIGHLRPGCHAANMECWSMLMSDSYEAELTLKRHLDKVSDRHGFNPVNVLYKSFNSEDSDTSLSQATTESVNDQGGNETSPVDDITESLEKAQMSPIQTRPTTRRGADGSKTRSSPYSRSCK
Protein: Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) (Q9Z0T0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
Subcellular location: Cytoplasm.
Interaction partners:
- Inosine triphosphate pyrophosphatase
- Xanthine dehydrogenase/oxidase
- Inosine-5'-monophosphate dehydrogenase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine-5'-monophosphate dehydrogenase 2
- GMP synthase
- Nucleotide triphosphate diphosphatase NUDT15
- Transmembrane O-methyltransferase homolog
Sequence:
MSLGIKEHPDAEVQKNRVLTLDDWQDKWVTRHIAFHQEQGHQLLKKHFDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLTEIAGAKVFKSSSGNISLYCCSIFDLPRANIGKFDRIWDRGALVAVNPGDRDRYADIILSLLRKGYHYLLVVLSYDPTKHTGPPFYVPDAELKKLFGTKCNMQCLEEVDALEERHKTWGVDYFFEKLYLLTEK
Protein: Methyl-accepting chemotaxis protein Amb0994 (Putative torque-sensing protein Amb0994) (Q2W8M7)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Probable methyl-accepting taxis protein. May be the receptor that senses the torque generated from the interaction between the magnetosome dipole moment and the external magnetic field (Probable). Overproduction interferes with magnetotaxis, cells respond more slowly to changes in the magnetic field; requires the MamK-interacting C-terminus of the protein. The effect of magnetic sensing is to control flagellar rotation.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:20471399}; Multi-pass membrane protein {ECO:0000255}. Note=Found predominantly at cell poles or at septa where divison occurs. {ECO:0000269|PubMed:20471399}.
Interaction partners:
- FOG: PAS/PAC domain
- PAS/PAC domain
- FOG: PAS/PAC domain
- Chemotaxis protein CheA
- Chemotaxis protein CheA
- PAS/PAC domain
- Chemotaxis signal transduction protein
- PAS/PAC domain
- protein-glutamate O-methyltransferase
- Protein-glutamate methylesterase/protein-glutamine glutaminase 1
Sequence:
METTLGSYARTLSLGMLVPSAICLLAGTFGLLGGSSIALWVVIAVSLLGVVGGVKIGGSARRMAGDLSTAIHVLSRSASGDLNARILDVRGSGGIGALQHSINRLLDLAEAFGKEAFAAVESANHGRYYRRIITTGLRGDFVLYAKTINQALKRMEARDAEFIAFANNQVKPVVNAVAAAATELEASSGAMSAQSTDTSHQAMTVAAAAEQASVNVQAVASAVEEFSASIKEISTQVHRAAAVASEAAGVASRTDTTVHGLSDAAQRIGAIVSLINDIAAQTNLLALNATIEAARAGDAGKGFAVVANEVKNLANQTARATEDITSQVAHIQEVAAEAIKAIQEITRTVSQIEETSSAVAGAVEEQNAVTVEIARNVAEAATGTSSVSSAIITVQATAAEATESAGQVADAASELSRQSENLSREVDGFIARIGGR
Protein: Sptbn4 protein (Q5BJU8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
SAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAVTEQVRPRPERQELADRAEELPRRRRSERQESTDQPEEAARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGLPAAVPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVNLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK
Protein: Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) (P35749)
Organism: Homo sapiens (Human)
Function: Muscle contraction.
Subcellular location: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
Interaction partners:
- Actin, aortic smooth muscle
- Actin, gamma-enteric smooth muscle
- Myosin regulatory light polypeptide 9
- Myosin light polypeptide 6
- Core-binding factor subunit beta
- Myosin regulatory light chain 12B
- Calponin-1
- Actin, cytoplasmic 1
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin regulatory light chain 12A
Sequence:
MAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE
Protein: IMP U3 small nucleolar ribonucleoprotein 4 (IMP4, U3 small nucleolar ribonucleoprotein, homolog (Yeast)) (U3 small nucleolar ribonucleoprotein protein IMP4) (Q6DI25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Nucleolar complex protein 4 homolog
- U3 small nucleolar ribonucleoprotein protein IMP3
- U3 small nucleolar RNA-interacting protein 2
- WD repeat domain 36
- PWP2 small subunit processome component.
- U3 small nucleolar ribonucleoprotein protein MPP10
- Transducin beta-like 3.
- BMS1 ribosome biogenesis factor
- Cirrhosis, autosomal recessive 1A
- Bystin-like.
Sequence:
MLRREVRLRKEYLYRKAQEDRLRTIEEKKQKLKSALDENRLLPTEVRKEALEVQKLLEFDDEGGEGVSSHMDDEYKWAGVEDPKIMVTTSRDPSSRLKMFAKEMKLMFPGAQRMNRGNHEVKTLVHACKSNNVTDLVIVHETRGQPDGLVVCHLPFGPTAYFTMYNVVMRHDVPDIGTMSEAYPHLIFHNFTSRLGRRVSNILKYLFPVPKEDSRRVITFANTDDYISFRHHTYKKTDHKNVELTEVGPRFEMKLYMIKLGTLENESTADVEWRHHPYTRTAKKRKFLSVE
Protein: Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494) (Q8NAM6)
Organism: Homo sapiens (Human)
Function: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Chromosome, telomere {ECO:0000250}.
Interaction partners:
- Tripartite motif-containing protein 43
- Double homeobox protein 4-like protein 2
- Methyl-CpG-binding domain protein 3-like 2
Sequence:
MALDLRTIFQCEPSENNLGSENSAFQQSQGPAVQREEGISEFSRMVLNSFQDSNNSYARQELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKASVKEKWKSSGKNLERFIEDLTDDSINPPALVHVHMQGQEALFSEDMPLRDVIVHLTKQVNAQTTREANMGTPSQTSQDTSLETGQGYEDEQDGWNSSSKTTRVNENITNQGNQIVSLIIIQEENGPRPEEGGVSSDNPYNSKRAELVTARSQEGSINGITFQGVPMVMGAGCISQPEQSSPESALTHQSNEGNSTCEVHQKGSHGVQKSYKCEECPKVFKYLCHLLAHQRRHRNERPFVCPECQKGFFQISDLRVHQIIHTGKKPFTCSMCKKSFSHKTNLRSHERIHTGEKPYTCPFCKTSYRQSSTYHRHMRTHEKITLPSVPSTPEAS
Protein: Epididymis secretory sperm binding protein (GABA(A) receptor-associated protein) (GABARAP protein) (HCG1987397, isoform CRA_b) (Q6IAW1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL
Protein: Serine/threonine-protein phosphatase BSL1 homolog (EC 3.1.3.16) (BSU1-like protein 1 homolog) (Q60EX6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 45
- Os06g0298400 protein
- Os01g0514300 protein
- Os09g0249700 protein
- Cleavage and polyadenylation specificity factor subunit 2
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Os01g0951000 protein
- Os05g0543300 protein
- Os07g0589400 protein
- PP2A regulatory subunit TAP46
Sequence:
MGTAGKGAWVVPAPAYREVEGWEGAGDDSPGFRCGHSLTVVAPTKGHGPRLILFGGATAIEAGASSGMPGIRLAGVTNSVHSYDVDTRRWTRLHPAGEPPSPRAAHAAAAVGTMVVFQGGIGPAGHSTDDLYVLDLTNDKFKWHRVVVQGAGPGPRYGHCMDLVAQRYLVTVSGNDGKRVLSDAWALDTAQKPYRWQKLNPDGDRPSARMYATASARTDGMLLLCGGRDASGMPLSDAYGLLMHTSGQWEWTLAPGVSPSPRYQHAAVFVGARLHVTGGVLRGGRAIEGEGAIAVLDTAAGVWLDRNGIVTSRTLKSSHDHDASSDLLRRCRHAAASVGTQIYIYGGLRGDILLDDFLVADNAPIQSEFTSSMYDRVPRAENQNRNHNFNSDSPTTNNSTDKKSIDMLTQASAAEAEAVSAVWRAAQEASHASSEDSLSEGIGSESPLSETSPMPEDLDDGGSLEPDVKLHSRAVVVSKEAVGDLGCLVRQLSLDQFENESRRMHPSSNDQSYPAKKALNRQRSPQGLHKKVISFLLKPRNWRAPAERAFFLDSYEVGELCYAAEQIFMQEPTVLQLKAPIKVFGDLHGQFGDLMRLFDEYGYPSTAGDITYIDYLFLGDYVDRGQHSLETITLLLALKIEYPENVHLIRGNHEAADINALFGFRLECIERMGESDGIWAWTRFNQLFNYLPLAAMIEKKIICMHGGIGRSINTIEQIEKLERPITMDVGSIILMDLLWSDPTENDSVEGLRPNARGPGLVTFGPDRVTEFCKRNRLQLIIRAHECVMDGFERFAHGQLITLFSATNYCGTANNAGAILVVGRGLVIVPKLIHPLPPPVNSPESSPERAMDATWMQELNIQRPPTPTRGRPQSASDRNSLAYI
Protein: Crotamine-IV-3 (P86194)
Organism: Crotalus durissus cumanensis (South American rattlesnake)
Function: Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, and hind limb paralysis (By similarity). It also induces potent blockade of neuromuscular transmission in young chicken biventer cervicis preparation and potent myotoxic effect. In mice, it induces myonecrosis, upon intramuscular or subcutaneous injections.
Subcellular location: Secreted {ECO:0000269|PubMed:17828447}.
Interaction partners:
Sequence:
YKQCHKKGGHCFPKEVLICIPPSSDFGKMDCRWKRKCCKKRS
Protein: FMN-dependent NADH:quinone oxidoreductase (EC 1.6.5.-) (Azo-dye reductase) (FMN-dependent NADH-azo compound oxidoreductase) (FMN-dependent NADH-azoreductase) (EC 1.7.1.17) (P41407)
Organism: Escherichia coli (strain K12)
Function: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. Can reduce several benzo-, naphtho-, and anthraquinone compounds.
Interaction partners:
- Uncharacterized NAD
- NADPH:quinone oxidoreductase MdaB
- Quinone reductase
- Oxygen-insensitive NADPH nitroreductase
- Oxygen-insensitive NAD
Sequence:
MSKVLVLKSSILAGYSQSNQLSDYFVEQWREKHSADEITVRDLAANPIPVLDGELVGALRPSDAPLTPRQQEALALSDELIAELKAHDVIVIAAPMYNFNISTQLKNYFDLVARAGVTFRYTENGPEGLVTGKKAIVITSRGGIHKDGPTDLVTPYLSTFLGFIGITDVKFVFAEGIAYGPEMAAKAQSDAKAAIDSIVSA
Protein: Very-long-chain 3-oxoacyl-CoA reductase-like protein At1g24470 (EC 1.-.-.-) (Beta-ketoacyl reductase 2) (AtKCR2) (Q9FYL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable reductase, but unlike KCR1, has no beta-ketoacyl-coenzyme A reductase activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19439572}; Single-pass membrane protein {ECO:0000269|PubMed:19439572}.
Interaction partners:
- Very-long-chain enoyl-CoA reductase
- Very-long-chain
- Very-long-chain
- 3-ketoacyl-CoA synthase 5
- 3-ketoacyl-CoA synthase 16
- 3-ketoacyl-CoA synthase 3
- 3-ketoacyl-CoA synthase 18
- 3-ketoacyl-CoA synthase 10
- 3-ketoacyl-CoA synthase 8
- Very-long-chain 3-oxoacyl-CoA reductase 1
Sequence:
MQGACISESQPWYLHFVCFIGFLFLLRVLFIPLLKWFTTRFLLTPKRLKRYGSWAMVTGATEGIGRAFAHELAKHGLNLILVSRNLSKLESVSDDFQQEFPHIKIKIIPFDFSSEGGYGAIEEGIKGLEVGILINNVGITYPRAMFFHEVDQLTWTKILRVNLEATTWVTRSLIGPMLHRRRGAIVNISSGAAVVVPSHPLYAIYAATKAYVDALSRSLHVEYKQFGIDVQCQVPLYVSTRMVSEVAAIDKPSLFVPSPEVYAKAAVAQIGIGSRCSPFWAHSLQWFLVGLVPDNLVDTWRLSIGLRRRSLS
Protein: Uncharacterized protein C725.03 (O94322)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MSLAWKNELLKLLKENVDSSGVIHPEYFQLATLPTGNEIYPRNRTVAIRGFVGTGWHKPRPDDVLATDLLVFSTDIASHKAAEIAEQQKNTFPSGPIPNAFEMCGWLPKTMQQIRISGQIWLYTPELADRNEFPADKLIQDHLINSNGRIPEEWSWEEERRRIWELHSPELRASFSTPPSYSKYQGDVKVSPLPSTLTGKEDPGVIEAWKTAWGRFSLVVCEANEVEFLNLTPPPGKRVLHNRDLNTKQWSSTRVNV
Protein: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) (P9WG49)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Interaction partners:
- ERCC4 domain-containing protein
- DNA polymerase I
- Protein RecA
- Uncharacterized protein Rv1278
- Leucine--tRNA ligase
- Phenylalanine--tRNA ligase beta subunit
- Calcineurin-like phosphoesterase domain-containing protein
- ATP-dependent helicase DinG
- Beta sliding clamp
- DNA-directed RNA polymerase subunit alpha
Sequence:
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
Protein: Rho guanine nucleotide exchange factor (GEF) 19 (Rho guanine nucleotide exchange factor 19) (E7EY47)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- CDC42 small effector protein 1
- Serine/threonine kinase 17a
Sequence:
MLPGYGISPLLDFQPHLQAFHCRGESSDMWFPGSVETQALSDSREGRPLLRQHQHIAVCQQETLAFIDLQEQSVNGFQSCTSENCSSSLCSKPLRCNGRSPSDFAKTESTDRALDDYLTEDINNVEVVQEQSWTYITGLPETVHENPDSGVKGLNPRNLFLPLSPIYAPGDRNSLESQQLSSPSSPLEGPDPFRPQRRTSLGSIKEKSIRRKMRVYSPDTLEASPSSPGVECDYLLPASFESFVEGGLGMVGSTIPTSQTSSPLPGLDEDLSLFAIPNSPKPFLNPLQEGARCQEGVNDEGRQRLGLEDCGTLQGPPLNSGTSMPLSRSRSVDNERRRFSASELISRLQLSQRKNSFTLKLGKSLSARVASRERHLSGNLSSDYKPNSRHRFSGGSSDSGPHSPVGSAPPLPSADSNQPLHRRSSKQRMRKVSVDEDGGSPPSNSKRLSRFLPSLILYQEYSDVAINREIQRQQGAEPGTDEERGESVSPGNLSPSSSFRSSRGSAFSLWQDIPDVRSSGQLDNFSNEERKLQEAKFELVTSEASYIRSLSIAVDHFMMSSELCECLGTQERQWLFSKLPDVKEVSERFLQDLERRLEGDILRFDVCDIVLDHCPALRRVYLPYVTNQAYQEQTYQRLLQENARFPGILARLEEDPICQRLPLTSFLILPFQRITRLKMLVENILKRTTPGSRDEDTATKALNELKKIIKECNSSVQSMKRMEELIHLNKKIHFEGKIFPLISQSRWLVKHGELLEVDTQNLSISGSKFKLTTRPVYLHLFNDCLLLSRRKESWKFMVFVHAKIEDLKVKDLSQKLQGISGFIFYLQLCEGQQLKHQILLKSPTESSKQRWITAMFPSDPTTAIEQTNENDDLSQVQCIRSYQAQEHDELTLEKADILQAVTITSDGWVEGIRLSDGERGWFPKTYVEEITSRSARLRNLRENIRIKCVSQKLEGETL
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (P00445)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11500508}. Mitochondrion intermembrane space {ECO:0000269|PubMed:11500508, ECO:0000269|PubMed:22984289}. Note=A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space. {ECO:0000269|PubMed:11500508}.
Interaction partners:
- Superoxide dismutase, mitochondrial
- Superoxide dismutase 1 copper chaperone
- Cytochrome c oxidase copper chaperone
- Peroxisomal catalase A
- Catalase T
- Small ribosomal subunit protein mS43
- Small ribosomal subunit protein mS42
- Copper metallothionein 1-1
- Copper transport protein CTR3
- Iron transport multicopper oxidase FET3
Sequence:
MVQAVAVLKGDAGVSGVVKFEQASESEPTTVSYEIAGNSPNAERGFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKDSLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLTN
Protein: Solute carrier family 25 member 35 (Q3KQZ1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSAAAGAMAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQPTDAQGKGLMYRGILDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRSLYYTDTK
Protein: Nuclear receptor domain-containing protein (Q9NAJ3)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Palmitoyltransferase
- Nuclear Hormone Receptor family
- Paired box protein 1 homolog
- Nuclear hormone receptor family member nhr-49
- CYtochrome P450 family
Sequence:
MVPGPKKRAPKPCLVCGIEKGTLHFGSVVCMACASFFRRTVSFHIRFLCRYSNNCQISQDLRFICRSCRFDKCERVGMRRDLVQQKRNENKLPKYVLESRKGGAGEVVRGYITSAYTAEPRRLKEPATSSAAEPEDGFSIILNMKHDDLLVYYVEEIRNSVRARQQGGIVMSPQNFLETKHRTDQFALDICTMCPGTDLLENPDFEVLYKYCSFSSLWMDLSWINASQDDWNKVLVEKDYTEIPLITYMNQFQATVTAQLARLQLDIFEYAALKSMCIWKLGLLDSTLTLKIVSAEHYYGITCALSKYYRVTKRLEQFEMATRIAEITLLIGPIFNVYRDMLVLYHNLQIEDRFKEE
Protein: Transcription factor bHLH148 (ATBS1 interacting factor 2) (Basic helix-loop-helix protein 148) (AtbHLH148) (bHLH 148) (Protein RSA1 INTERACTING TRANSCRIPTION FACTOR 1) (AtRITF1) (Transcription factor EN 143) (bHLH transcription factor bHLH148) (Q9C8Z9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: bHLH transcription factor that binds DNA on specific sequence 5'-CANNTG-3' in target gene promoters. Negatively regulates brassinosteroid signaling. Together with BHLH148/RITF1, regulates the transcription of several genes involved in the detoxification of reactive oxygen species (ROS) generated by salt (NaCl) stress. Confers tolerance to salt and to the oxidative stress-inducing reagents hydrogen peroxide H(2)O(2) and methyl viologen (MV).
Subcellular location: Nucleus {ECO:0000269|PubMed:24009530}.
Interaction partners:
- Protein RGF1 INDUCIBLE TRANSCRIPTION FACTOR 1
- Transcription factor PRE3
- Protein SHORT ROOT IN SALT MEDIUM 1
- At3g60670
- Protein GOLVEN 11
- Transcription factor IBH1
- Transcription factor UPBEAT1
- Transcription factor PRE1
- Transcription factor PRE2
- U-box domain-containing protein 6
Sequence:
MASLISDIEPPTSTTSDLVRRKKRSSASSAASSRSSASSVSGEIHARWRSEKQQRIYSAKLFQALQQVRLNSSASTSSSPTAQKRGKAVREAADRALAVSARGRTLWSRAILANRIKLKFRKQRRPRATMAIPAMTTVVSSSSNRSRKRRVSVLRLNKKSIPDVNRKVRVLGRLVPGCGKQSVPVILEEATDYIQALEMQVRAMNSLVQLLSSYGSAPPPI
Protein: acetyl-CoA carboxylase (EC 6.4.1.2) (A0A0G2K1F2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MVLLLFLTCLVFSCLTISWLKIWGKMTDSKPLSNSKVDASLLSSKEESFSASDQSEEHGDCSCPLTTPDQEELASHGGPVDASQQRNSVPSSHQKPPRNPLSSNDTCSSPELQTNRVAAPGSEVPEANGLPFPARPQTQRTGSPTREDKKQAHIKRQLMTSFILGSLDDNSSDEDPSASSFQTSSRKGSRASLGTLSQEAALNTADPESHTPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGNRVIETVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGPNNNNYANVELIIDIAKRIPVQAVWAGWGHASENPKLPELLCKHEIAFLGPPSEAMWALGDKISSTIVAQTLQIPTLPWSGSGLTVEWTEDSQHQGKCISVPEDVYEQGCVRDVDEGLQAAEKVGFPLMIKASEGGGGKGIRRAESAEDFPMLFRQVQSEIPGSPIFLMKLAQNARHLEVQVLADQYGNAVSLFGRDCSIQRRHQKIIEEAPATIAAPAVFEFMEQCAVLLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPVSFETPLSPPIARGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLVNLLETESFQNNDIDTGWLDHLIAQRVQAEKPDIMLGVVCGALNVADAMFRTCMTEFLHSLERGQVLPADSLLNIVDVELIYGGIKYVLKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGSSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLMQYTVEDGQHVEVGSSYAEMEVMKMIMTLNVQESGRVKYIKRPGAVLEAGCVVAKLELDDPSKVHAAQPFTGELPAQQTLPILGERLHQVFHSVLENLTNVMNGYCLPEPFFSMKLKDWVEKLMMTLRHPSLPLLELQEIMTSVAGRIPVPVEKAVRRVMAQYASNITSVLCQFPSQQCWASGMLGKHSTTELQPELLKIATILDCHAATLQRKVDREAFFMNTQSIVQLIQRYRSGTRGYMKAVVLDLLRRYLNVEHHFQQAHYDKCVINLREQFKPDMTRVLDCIFSHSQVAKKNQLVTMLIDELCGPDPTLSEELTSILKELTQLSRSEHCKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRELPDGTCVVEFQFMLPSSHPNRMAMPINVSDPDLLRHSKELFMDSGFSPLCQRMGAMVAFRRFEEFTRNFDEVISCFANVPTDTPLFSKACTSLYSEEDSKSLQEEPIHILNVAIQCADHMEDERLVPVFRAFVQSKKHILVDYGLRRITFLIAQEREFPKFFTFRARDEFAEDRIYRHLEPALAFQLELSRMRNFDLTAVPCANHKMHLYLGAAKVKEGLEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPLKIEESVRAMVMRYGSRLWKLRVLQAEVKINIRQTTSDCAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGSLHGMLINTPYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALFKLWGSPEKYPKDILTYTELVLDSQGQLVEMNRLPGCNEVGMVVFKMRFKTPEYPEGRDTIVIGNDITFQIGSFGIGEDFLYLRASEMARTEGIPQIYLAANSGARMGLSEEIKQIFQVAWVDPEDPYKGFRYLYLTPQDYTQISSQNSVHCKHIEDEGESRYVIVDVIGKDSSLGVENLRGSGMIAGEASLAYEKNVTISMVTCRAIGIGAYLVRLGQRVIQVENSHIILTGAGALNKVLGREVYTSNNQLGGVQIMHTNGVSHVTVPDDFEGVCTILEWLSYIPKDNQSPVPIITPSDPIDREIEFTPTKAPYDPRWLLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRSVEVAVPADPANLDSEAKIIQQAGQVWFPDSAFKTAQVIRDFNQEHLPLMIFANWRGFSGGMKDMYEQMLKFGAYIVDSLRLFKQPVLIYIPPGAELRGGAWVVLDSSINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLVKTIRRIDPVCKKLLGQLGTAQLPDKDRKELESQLKAREDLLLPIYHQVAVQFADLHDTPGHMLEKGIISDVLEWKTTRTYFYWRLRRLLLEAQVKQEILRASPELSHEHTQSMLRRWFVETEGAVKAYLWDSNQVVVQWLEQHWSARDNLRSTIRENINYLKRDSVLKTIQSLVQEHPEATMDCVAYLSQHLTPAEQMQVVQLLSTTESPASH