wanglab/gogpt-training-data huggingface dataset:
Protein: Guanylate binding protein 4 (A4UUI4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSLWAPPCSLRPRASGCGACPTPPSQSTGPPGHRGPGRCGKG
Protein: RE65159p (Q8SWT5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MADVSDPSELFDLELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYGT
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) (Q9TT93)
Organism: Bos taurus (Bovine)
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- Brevican core protein
- Collagenase 3
- Stromelysin-1
- Collagen alpha-1
- Interleukin-6
- Interleukin-1 beta
- Interstitial collagenase
- Metalloproteinase inhibitor 3
- Matrix metalloproteinase-9
Sequence:
MSHMDSHPGRGLADGWLWGIQPRLLLPTVPVSGSRLVWLLLLASLLPSAWPASPLPREEEIVFPEKLNGSVLPGLGAPARLLYRLPAFGETLLLELEKDPGVQVEGLTVQYLGRAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGTELHIQPLEGGAPNSAGGPGAHILRRKSPVSGQGPMCNVKAPPGKPSPSPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVVLGPGEEGPQVGPSAAQTLRSFCAWQRGLNTPDDADPGHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFSMLHDNSKQCTGLNGPESTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGFGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHVDQLQAFNVPQAGGWGPWGSWGDCSRSCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTQDCPTGSALTFREEQCAAYNHRTDLFKNFPGPMDWVPRYTGVAPRDQCKLTCQTRALGYYYVLDPRVADGTPCSPDSSSVCVQGRCIHAGCDRVIGSKKKFDKCMVCGGDGSSCSKQSGSFKKFRYGYNNVVTIPAGATHILVRQQGSPSVRSLYLALKLPDGSYALNGEYTLIPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAEPLTLQVLVAGNPQNARLRYSFFVPRPRPVPSTPRPTPQDWLRRKSQILEILRRRSWAGRK
Protein: Uncharacterized protein (Q586T8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MATRGVAPPPPVVRVPLLEPTPTSVTAARSLWGKPPALPSTGSILTDHYQTAHPGRVLESVACAETAILDSAARMAHIEELLRSVHKHCDAPTRETAAVAGALPQSECTKAKCRTPIGTSLEQREDQRHRGKGLRPPSPRPPRRDESPAKPGWNRRTPTPRKKPVVSDPVTEPRRVTRSSSADNPRRPQQEGLKRVGSTGSDAHTQRVSGKSYAAPSESVRRPSNRSAPSNSRASSVVVSLARKAEGTTTLDSVGREPSVIDSRLDFMQSALRDAQERATRAEARCEELEVAFHALKLQHDEATTRLEERQSQLVAQVQYLLQWVRQLEEAILVKGEVLLTKTECVDGAGVARGSQNRCVTEEANSGSLLAPGGTRGKPVHQETGAKGVTLRVPPTPPMALRLQHK
Protein: CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (C0H5B7)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phosphatidate cytidylyltransferase
- 1-phosphatidylinositol 4-kinase
- phosphatidylinositol 3-kinase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative
- Phosphatidylserine decarboxylase proenzyme
- PAP2-like protein, putative
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Inositol-3-phosphate synthase 1
- Phosphatidylinositol N-acetylglucosaminyltransferase, putative
Sequence:
MKMKKKNVYLYIPNIIGYIRVILALLGFIISRKNLFLFVCFYSVSQVLDALDGWTARKFNQTSVFGQILDQITDRLSTSLLYLLNSSVYEEYITLIGLIMIADIAGHYFHSTSCAIAGNKTHKKIEKGNKLLKLYYEKPWVMVICIIAYESFLICAYLLRVAVKKSLIYKLSYYALICSFPLAAFKMFTNVSQGVHGVKCLVDMDCKKK
Protein: Myosin Ic, paralog b (A0A2R8Q9G7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, stereocilium membrane {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MMELKIQLIPTGEIILPPGKNGEFYCQSCTKAVGSDGIRVMMESALTARDRVGVQDFVLLENHTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDLEIYTKQHMERYRGVNFYEVSPHIYAVADNAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAVTCPASDHVQTVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSRVVHQSNGERNFHIFYQLIEGGEDDLLRRLGLERNAQQYQYLVKGNCPKVSSINDRNDWKTVRKALSVIGFTDDEVEELLNIIASVLHLGNVQYGGEDSGSAYITTDTQIKYLARLLGVDGTVLKEALTHKKIIAKGEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKNASVIGLLDIYGFEVFQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGDASDITFLEKLENTVGGHAHFLTHKLADGKTRKVMGREEFRLIHYAGEVNYNVKGFLDKNNDLLFRNLKQVMCMSENKILNQCFDREELSDKKRPETAATQFKNSLAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRRYETFLQRYKSLCPDTWPNWDGRQVDGVSTLVKHLGYKPEEYKLGRTKIFIRFPKTLFATEDALEVRKHSLATQLQSSWKGYSQKTKYQKMRHSAVWIQAWWRGILARRAAKRRREAADTIRRFIKGFIYRHQPRCPENEYFLDYVRYSFLMNLHRCQPKTVLDKSWPTPPPALVEASQHLRKLCMQNMVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYPQSVPKLFVNTRLNGEDINPKVLQALGNEKMKYAVPVIKYDRKGYKARNRQLLLMSDSAVIVEEGKLKQRIDYNSLKGISVSSLSDGMFVFHVASEDNKQKGDVVLQNEHVIETLTKVAICADKMDDININQGSIKFDVAQGKEGIIDFTAGSELLIVKAKNGHLSVTAPRLNSR
Protein: Presenilin-A (PS-A) (EC 3.4.23.-) (Q54ET2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Nicastrin
- Gamma-secretase subunit Aph-1
- Probable gamma-secretase subunit PEN-2
- ZZ-type zinc finger-containing protein
- PB1 domain-containing protein
Sequence:
MKENEDEINKTDEKYKIKNPSNNGNNKNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNSNLENIEGLNKYNIYKKKKGKNESNTSLNNIYISSPNLSERSDNSIGSYCTNKTMKSENSIINIETLFRDSVSEQNSDECGSKVDKDLDEDDDDDDDETEVPELVDYSEMIVSILYPVCITMVIVVLAIRAISSSTSKNSQIVEISNDNSGGNGDSSSGADKMVFDSVVNSLIFLAVIILSTTIMVVLYKFKLMKALYAWLMGTSILLLGVFGGFLFLILLAYLNLGLDYVTFVIVVWNFSVGGIVCIFWYSPKLLNQGYLISISVLMALFFSRLPDWTTWGILSIVSIYDIFAVLCPGGPLRILIETAQKRNENIPAMIYNASIYIGMIYNEDNLENNNNNNNNNNIELNINEVDIENNNNNEDENKNNTEDGNNNNNKNKNNNNNNNNRIENENGAENSSENGSITPPPTIPNFIKDEKEINRSSGSNGFPNFKKCANDNILIGDAETNDEIVSNAESSIDSTISESYVKPKQSIRLGLGDFVFYSVLIGKAASYQITTVFTVFIAIITGLFLTLILLAVFRRALPALPMSIIFGIIVFFLTFKILIQYIYFLGENQIFV
Protein: 3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B) (Q9QXQ1)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (By similarity).
Interaction partners:
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenine phosphoribosyltransferase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- GTP:AMP phosphotransferase AK3, mitochondrial
- Deoxycytidine kinase
- Adenylosuccinate lyase
- Adenylate kinase 8
- Adenylate kinase 2, mitochondrial
- Adenylate cyclase type 8
Sequence:
MSCLMVERCGEVLFESPEQSVKCVCMLGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGTWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENVQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSENMLSHLAHNKAQWKSLLSNQHRRRGSGQDLAGPAPETLEQTEGATP
Protein: Zinc finger protein with KRAB and SCAN domains 5 (Zinc finger protein 95 homolog) (Zfp-95) (Q9Y2L8)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Interaction partners:
- Zinc finger and SCAN domain-containing protein 20
- Zinc finger protein 232
Sequence:
MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHEASGPREALSQLRVLCCEWLRPELHTKEQILELLVLEQFLTILPEEFQPWVREHHPESGEEAVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRLLEENALPVLQVPSLPLKDSQELTASLLSTGSQKLVKIEEVADVAVSFILEEWGHLDQSQKSLYRDDRKENYGSITSMGYESRDNMELIVKQISDDSESHWVAPEHTERSVPQDPDFAEVSDLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDISPKQSTHGERGHRCSDCGKFFLQASNFIQHRRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQHHSVHSGERPYGCNECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVKKKISEYSEADMELSGKTQRNVSQVQDFGEGCEFQGKLDRKQGIPMKEILGQPSSKRMNYSEVPYVHKKSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHTGEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKSHQCRECGEIFFQYVSLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCDICGKAFGYSSDLIQHYRTHTAEKPYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGRGFTLKSHLNQHQRIHTGEKPFQCKECGMNFSWSCSLFKHLRSHERTDPINTLSVEGSLL
Protein: Mitochondrial import receptor subunit TOM6 homolog (Translocase of outer membrane 6 kDa subunit homolog) (Q9XIA7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: A component of the complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14730085, ECO:0000269|Ref.4}; Single-pass membrane protein {ECO:0000269|PubMed:14730085, ECO:0000269|Ref.4}.
Interaction partners:
- Mitochondrial import receptor subunit TOM5 homolog
- Cytochrome b-c1 complex subunit 10, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM13
- Mitochondrial import receptor subunit TOM20-4
- Ribosomal protein
- Mitochondrial import inner membrane translocase subunit TIM22-4
- Mitochondrial import receptor subunit TOM40-1
- Probable steroid-binding protein 3
- Mitochondrial import receptor subunit TOM20-1
Sequence:
MFPGMFMRKPDKAEALKQLRTHVALFGSWVVIIRAAPYVLSYFSDSKDELKIDF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A1D8PRI2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- tRNA
- Ribonuclease P
- Arf family GTPase
Sequence:
MDVLLSIFGTCLPCFPTLSSPSIIINNNKYRIIRLLGEGGFSYVYLVSSQSQPSSQYALKKIRCPYGIQDESFKNAVREIKNYHRFKSPYIISSIDELIQSETDGSKNIYILLPFFQKSLQDIINELVLNNSKMEESEILRVFIGTCRGLKVMHNHKKTATSTTRLDDDEQDVLLPTSEDDEYEDFTNSTDNNNNNNVQMQELVPFAHHDLKPANVMLSAEGLPVLCDLGSCSRARISVRNRQQALTVQEFAQEHCTLPYRAPELVDVATNCEITEKTDIWSLGCLLYCCCFGYSPFEKLEIEQGANLNLAILQGKYEIPKGNNGYDSKLIELIKKCLQLNPDSRPDIDELLNDVLELTRQLGT
Protein: RNA-binding protein, putative (Q57WD0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEVPFEEGTQLVHAIERSQQRILDASAVSDVETVPPPTTTANANATAAVAVALKGLATTSAHVPLPLFGLDDEGRSGKTPLNNESGPGTSSSGSHSSSSNVPVASLRAGTAGTPTVTPAADSRAESQSRTNLFVSNIPHLLGKNELVDLFSPYGEILSAAVMRNIHTGDSLGTAFVRFATTEQAQAAMEALTGYVLEGRSMVVQWAKRQHDDTPVGEARKKIVKLFVRNIPLDVSDADLTEVFSAFGPVKGVSIHKDTTPNAGRHLERRIAFITFHTDGVAERAAEAIHNTRPFHSCGKIPLMVKLAEDNPRHGRSHNAQSGRSAWGRNGNTNQNNDGSVSRSSPSGSVRSNKSLGISGHGSARGDIRGLGIDTPGGLPGLFSLGTDACGFPGGAFAVFPTMIPQGGVFVPQPVLNVGVGVNGQAMALRTPMFWHQAGSTIPVGVMGQSQSANMGATGGNCSHQGFASVSEGSSSEQQRVDIFSSFAQPPPFPTDPLAGLVDSTGFSFTAPPPPPPAPAPLSSSAVEVGPVVKDDVEPTMCPHPSSSDVYDADSSLSLDFLENLGAAELCHVTTPSGDEDHRLHAPGSFVPFL
Protein: SD10723p (Q8MQI1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
SVVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLLLDAGAPVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGGKATAAGSGDDSQDMKLGFSFGDDPTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQQQNNSTADLNMKIASVKKVWESATPMSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSGHMSAASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGHGYSHGSPFDAGSLEQQFQQEDYPSPQQQQQAHQKTKQLQQQQHLGMSPPPSQQQQQQHSQQQQQAQHQQQQQQAHQQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGGNLYAPFHSLDHSSRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGSLPPTAPTPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGAAKPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQGGPPPGAHQLQSNSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYGGHQGGPPGSNGPPGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTPGAAYLKGNQGQTHMQDSMGRQLKSPLSADMSLGLAKQVQSQPSPPHHKNYGAWDLQNQVLQQQQQQSQQQQQQQQRQVGGGNGPSMNALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQGRYPTPIQRPNNYPQHPQQQQQQQQQQQQQREQAAAAAVAAQRAQNMRQVTGAGGGVAGSAGGGGSQTPVGPAGGNGGPGGAGGGGGAGGAAGSGPGKPYYANNASGAAVAANRGEWHAN
Protein: Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) (Q13323)
Organism: Homo sapiens (Human)
Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:8816500}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:O70337}; Single-pass membrane protein {ECO:0000255}. Note=Around the nuclear envelope, and in cytoplasmic membranes. {ECO:0000269|PubMed:8816500}.
Interaction partners:
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 2
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Activator of apoptosis harakiri
- Bcl-2-like protein 11
- Bcl-2-modifying factor
- Bcl-2-related protein A1
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-like protein 10
Sequence:
MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMEDFDSLECMEGSDALALRLACIGDEMDVSLRAPRLAQLSEVAMHSLGLAFIYDQTEDIRDVLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK
Protein: Calcium uptake protein, mitochondrial (Mitochondrial calcium uniporter) (Q9SZ45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Calcium-binding protein maintaining matrix calcium levels at low concentration. Regulates mitochondrial calcium dynamics in planta by restricting influx.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:26530087}. Mitochondrion intermembrane space {ECO:0000269|PubMed:26530087}. Note=Located at the inner mitochondrial membrane and/or in the intermembrane space. {ECO:0000269|PubMed:26530087}.
Interaction partners:
- Calcium uniporter protein 3, mitochondrial
- Calcium uniporter protein 4, mitochondrial
- Chloroplastic calcium uniporter protein
- Calcium uniporter protein 2, mitochondrial
- Calcium uniporter protein 5, mitochondrial
- Calcium uniporter protein 1, mitochondrial
- Protein FREE1
- Mitochondrial intermembrane space import and assembly protein 40 homolog
- Mitochondrial proton/calcium exchanger protein
- Nucleoporin-like protein
Sequence:
MPALSHYRSVSSLPSVDRSFLLIQRLRIHGSSSSFPESSPSASILSGADPLKCTVSGGSLAKWITGISAGSALGFLYWSSGSSDSISGLFGGSNLLSFADSSTPSVCGVKVGDLKPRSFIPKLSLPGYSSGFIFGDAYRRKIFFNYEKRLRLQSPPEKVFEYFASVRTDKGEILMKPADLMRAIVPVFPPSESHLVREGYLTGERNPGELRCSPSEFFMLFDVDNDGLISFKEYIFFVTLLSIPESSFAVAFKMFDTDNNGEIDKEEFKTVMSLMRSQHRQGVGHRDGLRTGLHMTGSVEDGGLVEYFFGKDGSQKLKHDKFTKFMKDLTEEMLRLEFAHYDYKRRGSISAKDFALSMVAAADASHLSKLLDRVESLSEHPHLRDMRISLKEFKQFDELRSKLGPFSLALFAYGKANGLLTMKDFKRAASQVCGITLSDNVIEIAFHVFDSNQDGNLSVDEFLRVLHRRERDVAQPIAKGLSRYFSDGWKGSKNCSSS
Protein: Cyclin-D4-2 (G1/S-specific cyclin-D4-2) (CycD4;2) (Q0WQN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May promote cell division.
Interaction partners:
- Cyclin-dependent kinase A-1
- Retinoblastoma-related protein 1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-dependent kinases regulatory subunit 1
- Heavy metal-associated isoprenylated plant protein 18
- Regulator of chromosome condensation
- At2g44240/F4I1.5
- Cyclin-dependent kinase inhibitor 5
Sequence:
MAEFMEPNLVSNFDDEKSNSVDTRSIFQMGFPLESEEIVREMIEKERQHSPRDDYLKRLRNGDLDFNVRIQALGWIWKACEELQFGPLCICLAMNYLDRFLSVHDLPSGKAWTVQLLAVACLSLAAKIEETNVPELMQLQVGAPMFVFEAKSVQRMELLVLNVLRWRLRAVTPCSYVRYFLSKINGYDQEPHSRLVTRSLQVIASTTKGIDFLEFRASEIAAAVALSVSGEHFDKFSFSSSFSSLEKERVKKIGEMIERDGSSSSSQTPNNTVLQFKSRRYSHSLSTASVSSSLTSLS
Protein: Copine-2 (Copine II) (P59108)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Nucleus {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner (PubMed:21087455, PubMed:26175110). Colocalizes with CD2 at the cell membrane (PubMed:21087455). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}.
Interaction partners:
Sequence:
MAYIPDGGAPTAGAIPLGSQCCVCKVELSVSGQNLLDRDVTSKSDPFCVLFIEDNGRWMEFDRTETAVNNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSAQLDEHDFLGQFSCSLGTIVSSKKITRPLLLMNDKPAGKGVITIAAQELSDNRVITLSLAGRKLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDLEKPIQVMCYDYDSNGGHDFIGEFQTSVLQMSEARDGVPLEIECINPKKQRKKKSYKNSGIIILRSCKIHRNYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQQTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDNRRLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
Protein: FTH domain-containing protein (Q7YXC4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNTPNSSCTILFENLYDNDLALKLFNNRTIVDNILRNVKGDINNRLELRLVNKSFNLAAIHVIRKENRTVVFHKFNRCDRLHKISPCPDCSVHLNSVKLNKKNIFQYARFLKQTMKIMVIKIRIEDSKRVCCMITDVHQVIHKSLIGSDYDKVEEFVGIDQISFSTCIPCEKIAANCKVFGPVQNDMFNAILRLKHHYDVLQVKDMRLYKLMILNKEDPTVVEDFINSNITCSKLTIFLMYMYEKEAFGYSLPREFLDLLIKKWNVKTVEIVPRQDQPIPYYFHCNTDFIVPKAKFYVDYWTQPRSKYTLDGVEIDLQLTKVVEQQIKNRKSLFDNFIANARRIFPSNKITVRFSKEVCQEMMSQGNVEDFISGIILMTQKDAQPNSHISLKLYPEEVDAPLIDSFLRENFEKKFDSWNLETVSDSSANLPAEKCYQFFNQSTNCKIIFYICC
Protein: LD09786p (Lethal hybrid rescue) (Q95RV3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
Interaction partners:
- Hmr
- Heterochromatin protein 1
- Heterochromatin protein 6
- Homeobox protein unc-4
- GST-containing FLYWCH zinc-finger protein
- FI01426p
- Buddy of Hmr 2, isoform A
Sequence:
MCCRTLEKHSAKNIKMSTDSAEETVIHSTVPHLEINISNTNISGQIVLNDLLLMEMLARYPFLIIPQVEPKMDVDYDSWGWDQLAKSFNQSYEHVELSTPFSVSELKLRWVKLRPLVRALAGSKGQIPEPLWRVMHDVHIRMQAPNPADVPKTKCQEFLLSQLPFVKSMAQAERRHLEVEVLALILEQERQEKATRKLGPKDLETVQSEYDEFLKAIRVKELPADNLLSPAMDRFGISPHKIRPNVASANKRIRYNNACKGSNDVKIKIETAIEPKIKDTTKCDERPIETPRFVPLKSAKYYIKRCRIRLKRVEIDDYLPLARIRRSRRPTLRT
Protein: HTH-type transcriptional regulator GntR (Q9I1F6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in the regulation of glucose metabolism. Represses its own expression as well as that of the gluconate permease GntP. It employs an effector mediated de-repression mechanism: in the absence of ligand, GntR binds to the gntR and gntP promoters and represses their expression. The release of promoter bound GntR is induced by gluconate and 6-phosphogluconate that bind with similar apparent affinities to the GntR/DNA complex. The release of GntR leads to transcription of the genes.
Interaction partners:
- phosphoenolpyruvate--protein phosphotransferase
- phosphoenolpyruvate--protein phosphotransferase
- Gluconokinase
- HTH-type transcriptional regulator HexR
- Glutamate synthase large chain
- Gluconate permease
- ArsR protein
- Fructose transport system repressor FruR
- HTH gntR-type domain-containing protein
- Urate oxidase N-terminal domain-containing protein
Sequence:
MSITKNDKNTRTTGRPTLNEVARRAGVSPITASRALRGVASVAEELAQKVRDAARELGYVANPAARALASAQSHSVAVLVPSLANLLFIETLEAIHAVLRPQGLEVLIGNFHYSRNEEEDLIRNYLAYQPRGLLLTGFERTESARRMIEASGIPCVYMMDLDSGSGLNCVGFSQLRAGEAAAEHLLARGRRRLAYIGAQLDQRTLLRGEGFRRALQKAGCYDPGLEILTPRPSSVALGGELFVQLLASQPQVDGVFFCNDDLAQGALLEALRRGVKVPEQIAVLGFNDLPGSDCTVPRLSSIRTPREAIGRRAAEQLLALIAGKEVRDSALDMGFELMAREST
Protein: HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein) (P28068)
Organism: Homo sapiens (Human)
Function: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Interaction partners:
- HLA class II histocompatibility antigen, DM alpha chain
- HLA class II histocompatibility antigen, DR alpha chain
- HLA class II histocompatibility antigen, DO beta chain
- HLA class II histocompatibility antigen, DRB1 beta chain
- HLA class II histocompatibility antigen, DP alpha 1 chain
- HLA class II histocompatibility antigen, DP beta 1 chain beta chain)
- HLA class II histocompatibility antigen, DO alpha chain
- HLA class II histocompatibility antigen gamma chain
- HLA class I histocompatibility antigen, B alpha chain
- HLA class I histocompatibility antigen, C alpha chain
Sequence:
MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHTGAPEPILRDWTPGLSPMQTLKVSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS
Protein: Uncharacterized protein C16orf74 (Q96GX8)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein phosphatase 3 catalytic subunit alpha
- Protein unc-119 homolog A
Sequence:
MGLKMSCLKGFQMCVSSSSSSHDEAPVLNDKHLDVPDIIITPPTPTGMMLPRDLGSTVWLDETGSCPDDGEIDPEA
Protein: GH08125p (Q7K1H5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD31543p
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL14
- 40S ribosomal protein S15
- Large ribosomal subunit protein uL18
- 40S ribosomal protein S24
- Large ribosomal subunit protein uL5
- FI01658p
Sequence:
MRDRDRRDRDRDRERDRDRDRERDRERDRDRRHRSKSPSRSSRQVSKPKKKKAKKSKKYSRRSRSSSRSTSRSSSSSRSSSRSTHSKSRTRDHHKSRSISQRKTRGPSSESNSRSATTPAAAPVKAIDLFDTKVQKALETIDEDTFKPESFFSSRDSKETSDKVIIDLNNETVTVASKPATAVRNEDVIFHPNFLGDPDMKAEKWLRKLYNYRQKYMQE
Protein: Essential for maintenance of the cell wall protein 1 (P42842)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the maintenance of the cell wall integrity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14690591}. Nucleus {ECO:0000269|PubMed:14690591}.
Interaction partners:
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein 21
- U3 small nucleolar RNA-associated protein 12
- Glutamine--fructose-6-phosphate aminotransferase
- RNA cytidine acetyltransferase
- U3 small nucleolar RNA-associated protein 13
- Ribosomal RNA-processing protein 12
- U3 small nucleolar RNA-associated protein 10
- DNA-directed RNA polymerase I subunit RPA135
- Importin subunit beta-4
Sequence:
METLLHAKLLLSAEVESLKSGSFDQTYVKKAEHIISGESYQLVQQFVDKFKGKISISGEISTSSVIAALNDFLNVEVFKMGQENEMLFLAIALLQTFIQNNYTGPAARLKAISGLFGKTGIEIGAVNTALSRSLAIMGQPAYEFMDDPLYLVLSLLLLERITGQKSLFDVTPDQEIPLPIISAESTPGLLAVAYWWWARALLTQLSLIPEPSGFQASVASAIYQSADLAYAITKELPESIHEDFKRELCAMYYLENVKCSLAINTEHLCLPSLTRAKKITNFEFVMTGARATRTKYQQKAHAGLIILAKSFTFQNFALRTTSATPETFALESDLLLEKPHFESIADEPLDEQIYSKRQKVDLNEGYEEDKLLPLALRQENIPKLLLDLNPNDQPTLSDYDNIQLLLRLYTIKNTTPAKDPLVEEELTALLSRILYQNGDKNWSIFARSLWERSIIETTKAKTIERGLLQMQSLVEELDLKIKSKLVPSSSEINVASRLSYIHQLPFIPRWQLDATLAEKYMSLGILKSAVEIYERLGMACETALCYAAVGDEKKAEEILLQRINENDSDARAYSILGDIKQDPSLWEKSWEIGKYVNAKNSLAKYYFNPPPKSGAQPNYSATLKHLNDSLRQYPLSFETWYFYGCVGLQCGKMQIAAEAFTRCVSLDPYHALSWSNLSAAYTKMDKLKEAYSCLKRAISCDAQKNWKIWENYMLVAVKLNEWEDVLTACKQLVSIRRDKSGEGSIDLPIIEKLVELLVTSEYPEEPQQLSYFQKSCTEFICNTLPQVITTSARCWRLVARVELWRKRPWAALECHEKAYRAISHNPDLEVEEKVWNDTVDACEDLVAAYESLGEMEGKYGPGSLVCKDWKYKCRSTIKALMSKGKGRWDDSPGWDRLVEARSQI