Protein: Putative 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (Type III PIP kinase) (PIPkin-III) (O96838)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) or PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)) on the fifth hydroxyl of the myo-inositol ring, to form PtdIns(3,5)P2. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:16837550}. Note=Mainly associated with membranes of the late endocytic pathway.
Interaction partners:
- FIG4 phosphoinositide 5-phosphatase
- Protein VAC14 homolog
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol 4-kinase alpha
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase type 2
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase
Sequence:
MTSNNQNNSSSHQHLHSPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRKTSVGYQEERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEPQPPKSMDQSAEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNYNGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDPLRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEPGNKENQMQLLPAHDFVLMKITAPASSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPSCNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDPTRIYFTSWCSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENSPLVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTSDALAMARRALAESIELWGPRLQEIEKLTAKQAHHIDSGTICTEELRPEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTVNVYSDKKSIRKILTQLLPSGNQVNPLQSPFPAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGLSKV