Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma plc-3) (Phospholipase C-gamma plc-3) (PLC-gamma plc-3) (Q22070)
Organism: Caenorhabditis elegans
Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation of itr-1 and probably by activating TRPM channels gon-2 and gtl-1 by reducing PIP2 levels. By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, involved in avoidance behavior in response to nose touch. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and receptor let-23 and upstream of tpa-1 but not itr-1. During embryogenesis, may play an role in epidermal morphogenesis together with plc-1. Probably downstream of receptor daf-2, regulates male-sex muscle excitability in the absence of food.
Interaction partners:
- Receptor tyrosine-protein kinase let-23
- Inositol 1,4,5-trisphosphate receptor itr-1
- Inositol-trisphosphate 3-kinase homolog
- Probable type I inositol 1,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 3-kinase age-1
- PIPK domain-containing protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
- Diacylglycerol kinase
- Probable diacylglycerol kinase 3
- Phosphoinositide phospholipase C
Sequence:
MQHGSLGPSSSSRKTTVTSTAGSVHLHHRSSNGFSTASRAQLNRHNEMDFGKMFAAMEKGHKVCKIAVLKKWDPAYKQLTLDRYSRQIFLTKLELSAVRNKPTILDIRQIREVQTLNYKLNTIKVDDKWKKDREIVNFDSKAILIISYGMGFALSYWILLFESEDACKLWSQGLHNLMMDTRDRDSSPHPLRIERFLHKHFLSLMSPANDAVARKHMKPFVQTSLQFKVQSDQLQQVTEDQMNSDQFSFASRQLIHVPELFSSRFADLAEKHERKGLVVTFQNFLRFLDGKQFDELASNRTRALEFLNRYFQEDQAYFGDRNEPSMTVFEFCDFLFSRENSLWDPTNEKVTHDMSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGCRCIELDCWDGQKKPGSAEFIDIVIYHGYTMTSKILLRDVLHVIRHYAFVTSEYPVILSIEDNCSVPAQRLLAQELKDILGDYLLTQPANREEKQLPSPAALKKKIIVKHKKLPIESEDLAAVVKTDEFQDTEIISRECVKKGILMVKNNNSHEWTSHVFILFPDRLCYLIQTADPENPNDDTVSVSGDEEREEETPSGFGVKPEEMHVTEEWFHGRCERDEAKKRILEHKEKGNGLFMIRDSNLFIGDFSLSILHDGKVHHVRIRSKIIDKEKKYYFMDNKVCDTLYELVSYYTRHYLTTAHFKMVLTIPCPQPQPHLNQPWFSATADKEKAEELLSLVPEDGAFLIRTSSTDSSVYVLSLKVDGEFWHYRLKRDGRIFVVNQKVFENLNQIVEFYANREFVRGISLRFPVNEKDISHLTAELAEARTPGCYMDLKDLDKEVQARALRPYRGTADDELSFPANVIITVLRKEEGLWRGRYGSLTGWFPSAHVQEILPEKVSTSETSNYNTIELAGTLIERIHDADRPNVIRISQSNQHWMNKQYYLLAASSSEEADGWQNNLFELTRSVNTKMSILRTKEKEKRIAAELSNLVVYCQAVPFDPAHIYNDAFYEMCSFVEGKLDKLVEKGLLPFNSRKLSRVYPNGSRITSNNYSPVPMWNAGCHMVALNYQTGDKPMQLNQGKFLANGRCGYLLKPDYMLTDDFDPTNTEKFATAYPIRLNVQVIGGRHLSRKDKNKGICSPFVEIEIIGMPCDTKVFQTKTIASNGLNPIWNQTFTFEIQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSSLLVDVQMCSREGTQLIRSSSHFLQASRLAPVFAHRKITNGDSIPREMAPRLRTSATDRSLDSPTNSESRATLLSGQRGSQDSMDSAAETSSIASGTISSRDGKKKQNWLKKFSFGKSSKS