wanglab/gogpt-training-data huggingface dataset:
Protein: Sulfite reductase [ferredoxin], chloroplastic (ZmSiR) (EC 1.8.7.1) (O23813)
Organism: Zea mays (Maize)
Function: Essential protein with sulfite reductase activity required in assimilatory sulfate reduction pathway during both primary and secondary metabolism and thus involved in development and growth.
Subcellular location: Plastid, chloroplast stroma, chloroplast nucleoid. Plastid, chloroplast stroma. Plastid stroma.
Interaction partners:
- Ferredoxin-1, chloroplastic
- Adenosine 5'-phosphosulfate reductase
- Adenosine 5'-phosphosulfate reductase
- Ferredoxin--NADP reductase, chloroplastic
- uroporphyrinogen-III C-methyltransferase
- uroporphyrinogen-III C-methyltransferase
- Ferredoxin--NADP reductase, chloroplastic
- Ferredoxin--NADP reductase, chloroplastic
- Ferredoxin--NADP reductase, chloroplastic
- Adenylyl-sulfate kinase
Sequence:
MSGAIGGAEVHGFRGAAAQLPRSRVLGRPIRVAPPAAARPGGASAGSIRAVSAPAKKDASEVKRSKVEIIKEKSNFLRYPLNEELVSEAPNINESAVQLIKFHGSYQQTDRDVRGQKNYSFMLRTKNPCGKVPNQLYLAMDTLADEFGIGTLRLTTRQTFQLHGVLKKNLKTVLSTVIKNMGSTLGACGDLNRNVLAPAAPYVKKDILFAQQTAENIAALLTPQSGAYYDLWVDGEKIMSAEEPPEVTKARNDNSHGTNFPDSPEPIYGTQYLPRKFKVAVTAAGDNSVDILTNDIGVVVVSDDAGEPIGFNIYVGGGMGRTHRVETTFPRLADPLGYVPKEDILYAIKAIVVTQRENGRRDDRKYSRMKYMIDRWGIDRFRAEVEKYYGKKFESFRPLPEWQFNSYLGWQEQGDGKLFYGVHVDNGRVGGQAKKTLREIIEKYNLDVSITPNQNLILCGIDQAWREPITTALAQAGLLEPKDVDPLNLTAMACPALPLCPLAQTEAERGILPILKRIRAVFNKVGIKDSESVVVRITGCPNGCARPYMAELGFVGDGPKSYQIWLGGTPNQSTLAESFMDKVKLDDIEKVLEPLFTYWNGTRQEGESFGSFTNRTGFDKLKEVVNKWAESPSAA
Protein: Isovaleryl-CoA dehydrogenase, mitochondrial (EC 1.3.8.1) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (A0A0A0MT83)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MATATRLLGWRVASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
Protein: Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) (P28571)
Organism: Mus musculus (Mouse)
Function: Sodium- and chloride-dependent glycine transporter which is essential for regulating glycine concentrations at inhibitory glycinergic synapses.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P28572}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MIGGDTRAASAHPGMASAQGPVATPSPEQPFPGTTSVSLARPVLRVWHGAHSSGLLPNLIAQHSPAMAQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRFQDSRI
Protein: Gap junction alpha-8 protein (Connexin-50) (Cx50) (Q8K4Q9)
Organism: Rattus norvegicus (Rat)
Function: Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P55917}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000250|UniProtKB:P55917}.
Interaction partners:
- Gap junction alpha-1 protein
- Gap junction alpha-5 protein
- Gap junction alpha-4 protein
- Gap junction alpha-3 protein
- Lens fiber major intrinsic protein
- Gap junction beta-2 protein
- Filensin
- Tight junction protein ZO-1
- Beta-crystallin B2
- Gap junction gamma-1 protein
Sequence:
MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDQASIRKSSSSSKGTKKFRLEGTLLRTYVCHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLGMKGIRSAFKRPAEQPLGEIAEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMSRGYQETLPSYAQVGAQEVEREEQPVEEAVEPEVGEKKQEAEKVAPEGQETVAVPDGEKVETPGVGKDDEKEELQAEKVTKQGLSAEKAPTLCPELTTDDNRPLSRLSKASSRARSDDLTI
Protein: Prolyl endopeptidase (EC 3.4.21.-) (Q9VKW5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHTIFRGPLLYRRICQIVVPKTLPRNYIHRELPSNLTRAMPSTLSAKLAYPVARKDESVAEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPFLENGEEWKKLNTKLTKLWNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESKVFLDPNTLSEDGTIALTQKAFSEDGKYMAYGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWTKDNKGFFYGRYPDQDGKTDGSETKQNENQKLYYHRVGESQDKDTLVVEFPEEPSWRIQSTVSDCGKYLILAIVKDCRDNIVFYADLTPGAEITSKLNVKKIVEKFEADYDYITNEGSKIFFRTNKNAPNYQVIAIDFNNSAEDKWETLIAEHKSDVLDWVKCVDNDKLLVCYIRDVKSVLQVNSLKDGTLLREFDLDIGTIVGTSGEKKYSEIFYNFSSFLNPGSIYRYDFKTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFIIRKKRDSVEPRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDGVLAYPNLRGGGEYGEKWHNGGRLLNKQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQVGVMDMLRFHKFTIGHAWCSDYGNPSEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDDRVSPLHSLKFIAALQEAVRDSEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNVDIVNV
Protein: Cryptdin related sequence peptide (Q70LV9)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKKLVLLFALVLLAFQVQADSIQNTDEEIKTEEQPGEENQAVSVSFGDPQGSALQDAAVGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK
Protein: Interleukin-22 (G0LWV4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKFSTVQLVAAVVVVMSVCLLRESVAHSIHRPLSAPLHSADTDTMVQQVAQHAQSSDTDTDTKLMPDIDTKKNHRDICCLHANILDFYLSNILTTKEKQDKHHPKLPALKEDLARVSRDLKEHGCAIKHYNDHHHSIAFHKKLSEMEEGKGIKKAIGEIDILFTFLKDFCVHA
Protein: Hepatocyte growth factor-regulated tyrosine kinase substrate (A0A0S2Z4Q4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
Protein: Phosphoglycerate kinase (EC 2.7.2.3) (Q4GZG3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase, putative
- Glyceraldehyde-3-phosphate dehydrogenase
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
- Phosphoglycerate kinase
- Phosphoglycerate kinase
- Pyruvate kinase
- Glucose-6-phosphate isomerase
Sequence:
MSLKERKSINECDLKGKKVLIRVDFNVPLDDGNITNDYRIRSALPAVQKVLTEGGSCVLMSHLGRPKGVSMAEGKELRSTGGIPGFEQKATLKPVAKRLSELLSRPVTFAPDCLNAADVVSKMSPGDVVLLENVRFYKEEGSKSTEEREAMAKILASYGDVYISDAFGTAHRDSATMTGIPKILGHGAAGYLMEKEISYFAKVLGNPPRPLVAIVGGAKVSDKIQLLDNMLQRIDYLLIGGAMAYTFLKAQGYSIGISMCEESKLEFARSLLKKAEDRKVQVILPIDHVCHTEFKAVDSPLITEDQNIPEGHMALDIGPKTIEKYVQTIGKCKSAIWNGPMGVFEMVPYSKGTFAIAKAMGRGTHEHGLMSIIGGGDSASAAELSGEAKRMSHVSTGGGASLELLEGKTLPGVTVLDEKE
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (Q5B135)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Involved in osmoadaptation.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phosphoglycerate kinase
- Pyruvate kinase
- Fructose-bisphosphate aldolase
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
- Glucose-6-phosphate isomerase
- Triosephosphate isomerase
- Triosephosphate isomerase
- Phosphoenolpyruvate carboxykinase
- Transaldolase
- ATP-dependent 6-phosphofructokinase
Sequence:
MPISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRDGDKSKWLGKGVLTAVKNVNETIGPAVIKENLDVKEQSKIDEFLNKLDGTPNKSNLGANAILGVSLAIAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPDTASSFSEGLRQGAEVYHKLKALAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIHIAMDVASSEFYKPEEKKYDLDFKNPDSDPSKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAWSYFYKTSDFQIVGDDLTVTNPLRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTIADISVGLRSGQIKTGAPARSERLAKLNQILRIEEELGENAVYAGQNFRKSVNL
Protein: Engulfment and cell motility protein 1 (Protein ced-12 homolog) (Q92556)
Organism: Homo sapiens (Human)
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Subcellular location: Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Interaction partners:
- Dedicator of cytokinesis protein 1
- Dedicator of cytokinesis protein 2
- Adapter molecule crk
- Rho-related GTP-binding protein RhoG
- Ras-related C3 botulinum toxin substrate 3
- Dedicator of cytokinesis protein 5
- WD repeat-containing protein 35
- Engulfment and cell motility protein 3
- Engulfment and cell motility protein 2
- Ras-related C3 botulinum toxin substrate 2
Sequence:
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN
Protein: Transcription factor MYB27 (Myb-related protein 27) (AtMYB27) (Q9SCP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- RING-finger, DEAD-like helicase, PHD and SNF2 domain-containing protein
Sequence:
MDFKKEETLRRGPWLEEEDERLVKVISLLGERRWDSLAIVSGLKRSGKSCRLRWMNYLNPTLKRGPMSQEEERIIFQLHALWGNKWSKIARRLPGRTDNEIKNYWRTHYRKKQEAQNYGKLFEWRGNTGEELLHKYKETEITRTKTTSQEHGFVEVVSMESGKEANGGVGGRESFGVMKSPYENRISDWISEISTDQSEANLSEDHSSNSCSENNINIGTWWFQETRDFEEFSCSLWS
Protein: RNA-binding protein 34 (RNA-binding motif protein 34) (P42696)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Interaction partners:
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- RNA-binding protein 28
- Ribosome production factor 2 homolog
- CCAAT/enhancer-binding protein zeta
- Probable ATP-dependent RNA helicase DDX27
- Ribosome biogenesis protein BRX1 homolog
- Probable ATP-dependent RNA helicase DDX56
- Probable rRNA-processing protein EBP2
- WD repeat-containing protein 74
- ATP-dependent RNA helicase DDX24
Sequence:
MALEGMSKRKRKRSVQEGENPDDGVRGSPPEDYRLGQVASSLFRGEHHSRGGTGRLASLFSSLEPQIQPVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEPAKKVKAKKKHTNAEKKLADRESALASADLEEEIHQKQGQKRKNSQPGVKVADRKILDDTEDTVVSQRKKIQINQEEERLKNERTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRVDLASETSSRDKRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKFKQQNSNPRLKNVSKPKQGLNFTSKTAEGHPKSLFIGEKAVLLKTKKKGQKKSGRPKKQRKQK
Protein: Protein E4 (A7Y3Z3)
Organism: Human papillomavirus type 16
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
Interaction partners:
Sequence:
MADPAAATKYPLLKLLGSTWPTTPPRPIPKPSPWAPKKHRRLSSDQDQSQTPETPATPLSCCTETQWTVLQSSLHLTAHTKDGLTVIVTLHP
Protein: F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) (Q60584)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDSLHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEVANLALLGFGDVFALLFDNHYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGERPG
Protein: Helix-loop-helix protein hlh-12 (Q18277)
Organism: Caenorhabditis elegans
Function: Transcription factor which binds the E box motif 5'-GCAGGTG-3'. Involved in migration of the gonadal leader cells; distal tip cells (DTCs) in hermaphrodites, and linker cells in males. Positively regulates expression of alpha integrin ina-1 and ADAMTS protease gon-1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MAKKPRVTKLNTDRRSRANERERQRVSEMNGMFDVLLNLLPPSHFKTRLSRVQILREATSYIIRLHNFLIESSNSDIDAITVFPHIFNGERKSNKDAIRRPMKLKQGGGVAAFISRHELPPLQLPNPVIPILKPTSVPVWPQTNVYIAYF
Protein: Elongator complex protein 5 (Dermal papilla-derived protein 6) (S-phase 2 protein) (Q8TE02)
Organism: Homo sapiens (Human)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:22854966}. Cytoplasm {ECO:0000269|PubMed:16850183, ECO:0000269|PubMed:22854966}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 4
- Elongator complex protein 3
- Elongator complex protein 6
- Elongator complex protein 2
- Peroxisomal sarcosine oxidase
- Protein KTI12 homolog
- Cytoplasmic tRNA 2-thiolation protein 1
Sequence:
MLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI
Protein: Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF) (P04733)
Organism: Homo sapiens (Human)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Interaction partners:
- Metallothionein-1X
- Metallothionein-1H
- Metallothionein-1G
- Metallothionein-1M
- Metallothionein
- Metallothionein-2
- Metallothionein 1H-like protein 1
Sequence:
MDPNCSCAAGVSCTCAGSCKCKECKCTSCKKSCCSCCPVGCSKCAQGCVCKGASEKCSCCD
Protein: Interferon-inducible GTPase 1 (EC 3.6.5.-) (Q9QZ85)
Organism: Mus musculus (Mouse)
Function: GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.
Subcellular location: Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Parasitophorous vacuole membrane. Note=Localizes to the bacterial inclusions formed following C.trachomatis infection. Accumulates in a GTP-bound form on the parasitophorous vacuole membranes formed following T.gondii infection but exists in a GDP-bound form in uninfected cells.
Interaction partners:
- Guanylate-binding protein 2
- Guanylate-binding protein 7
- Immunity-related GTPase family M protein 2
- Guanylate-binding protein 3
- Guanylate-binding protein 6
- GTP-binding protein
- Immunity-related GTPase family M protein 3
- Immunity-related GTPase family M protein 1
- Antiviral innate immune response effector IFIT1
- Signal transducer and activator of transcription 1
Sequence:
MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN
Protein: Non-specific lipid transfer protein GPI-anchored 5 (AtLTPG-5) (Protein LTP-GPI-ANCHORED 5) (Xylogen like protein 12) (AtXYLP12) (AtXYP8) (Q9LJ86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lipid transfer protein involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition. Contributes to pre-invasive defense against some non-host powdery mildew pathogens by preventing the penetration of the epidermal cell wall by the fungal agents (e.g. Blumeria graminis f. sp. hordei (Bgh)).
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- Probable serine/threonine-protein kinase PBL15
- Glycine-rich cell wall protein-like protein
- HSR201-like protein
- Transmembrane protein
- Omega-hydroxypalmitate O-feruloyl transferase
- Small ribosomal subunit protein uS9x
- GDSL esterase/lipase At2g23540
- Protein indeterminate-domain 6
- Voltage-dependent L-type calcium channel subunit
Sequence:
MKMEMGLVFLTVFMAVMSSTMVSAQSSCTNALISMSPCLNYITGNSTSPNQQCCNQLSRVVQSSPDCLCQVLNGGGSQLGINVNQTQALGLPRACNVQTPPVSRCNTGGGGGGSTSDSPAESPNSSGPGNGSKTVPVGEGDGPPSSDGSSIKFSFPLIAFFSAVSYMAIF
Protein: Caldesmon 1 (F6T2Z7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XKLKGGSLGENQVEKMVEEKTPEIQEEAVLMVLENGQVSAEESKIEGDGEQDMEEIARRKKMGEEERERAEAERLRLEVEGQEQERIKAEQDRKLAEERARVEAEQKAAAEERERREAEERERREAEERERREAEERAEQARIQEEQRRVAEAQKKAKAEEEEKARIEEQRQKQQLEEQRSEKREAKDKGEKGAEKADRKGVNEREAPDDRLQTAVPKTQEKEEEKGVKGQAQRQKPRDDKPAFRKEEIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSPSRSGGRASGDKEAEGAPQVEAGKRLEELRRRRGETENEEFEKLKQKQQEAALELEE
Protein: Protein RALF-like 34 (Q9FHA6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- At4g16100)
- GATA transcription factor 23
- Jacalin-related lectin 32
- Probable membrane-associated kinase regulator 4
- Protein RALF-like 32
- Gibberellin-regulated protein 7
- Protein BASIC PENTACYSTEINE5
- Ricin B-like lectin EULS3
Sequence:
MAASSLNLLLILSLLTFISLQRSESLSDNPSLTLLPDGFDWPISHSDEFDIIDGEESFEVTEEDDGVTDRRSLYWRRTKYYISYGALSANRVPCPPRSGRSYYTHNCFRARGPVHPYSRGCSSITRCRR
Protein: E3 ubiquitin-protein ligase SINAT2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SINAT2) (Seven in absentia homolog 2) (Q9M2P4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex. Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitination and subsequent regulation of autophagosome assembly. Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex. Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex.
Subcellular location: Endosome, multivesicular body {ECO:0000269|PubMed:32753431, ECO:0000269|PubMed:32786047}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:32753431}.
Interaction partners:
- Ethylene-responsive transcription factor RAP2-2
- TNF receptor-associated factor homolog 1a
- TNF receptor-associated factor homolog 1b
- Ubiquitin domain-containing protein DSK2b
- Autophagy-related protein 13a
- U-box domain-containing protein 14
- Ubiquitin domain-containing protein DSK2a
- RING-H2 finger protein ATL72
- Senescence/dehydration-associated protein At3g51250
Sequence:
MAPGGSALKEVMESNSTGMDYEVKTAKVEVNNNKPTKPGSAGIGKYGIHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKLRVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQNLGCHDIFPYYSKLKHEQHCRFRPYTCPYAGSECSVTGDIPTLVVHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVTGRIWKEE
Protein: L-type lectin-domain containing receptor kinase SIT2 (EC 2.7.11.1) (Protein SALT INTOLERANCE 2) (Q7XUN6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Lectin-domain containing receptor kinase involved in salt stress response. Acts as negative regulator of salt tolerance.
Subcellular location: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVLPKPEMPFFVLLLFLGLGCLRPAAATDERFVFNGFTGANLSFDGMATVTSNGLLMLTNGTNQLKGHAFFPSPLQFQRGPNSTAMQSFSTAFVIGIIGAFEDLSSHGMAFIIAKSKNLTSALPGQFMGLVNSANNGNATNHLFAVEFDTILNSEFNDMSGNHVGIDVNGLNSVDADNAGYYDDGTGDFKNMSLVSRRPMQVWVDFDGQTMQVNVTMAPLEVARPKKPLLSKIVNISSVIDDTAYVGFSSATGILFCRHYVLGWSFKMNGAAPALNISSLPSLPVTFPKPRSKTLEIVLPIASAVLVFAVAAAVFVFMRRRRMFSELKEEWEVTFGPHRFSYKDLFHATDGFSDKRLLGIGGFGRVYRGVLPSSKAEVAVKKVAHGSRQGMREFVAEVVSIGRLRHRNLVQLLGYCRRKGELLLVYDYMPNGSLDKQLYDQGKITLRWAQRFRIIRGVASGLLYLHEDWEQVVVHRDIKASNVLLDADMNGRLGDFGLARLYDHGTDPHTTHVVGTMGYLAPELGHTGKASKASDVFAFGAFMLEVACGRKPVAQDARDNRVVLVDWVLDRWRAGAITDTVDPRLHGDFVESEASLVLRLGLLCSHPLPGARPGTRQLVQYLEGDVPLPELSPTYQSFNMLALMQDQGFDPYVMSYPMTSTSAGTFSDLSGGR
Protein: Leech factor Xa inhibitor (Lefaxin) (P86681)
Organism: Haementeria depressa (Leech)
Function: Potent anticoagulant inhibiting the amidolytic activity of factor Xa (F10) (Ki=4nM) and reducing its ability to activate prothrombin (F2) in the prothrombinase complex (EC(50)=40nM).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
FDVPEPFKWVDHFFYEKLDEQHKGLFFAFFDWGKGPDYWGKDTISLSQEQVDAKFELDLEYGIFYGNGETIENPSENGDLQGIFFSWGSE