wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PPT) (P53042)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (By similarity). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (By similarity). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (By similarity). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (By similarity). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (By similarity). Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12176367}. Cytoplasm {ECO:0000269|PubMed:12176367}. Cell membrane {ECO:0000250|UniProtKB:P53041}. Note=Predominantly nuclear. But also present in the cytoplasm. Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner. {ECO:0000250|UniProtKB:P53041}.
Interaction partners:
- Hsp90 co-chaperone Cdc37
- mitogen-activated protein kinase kinase kinase
- Heat shock protein HSP 90-beta
- Prostaglandin E synthase 3
- Heat shock protein HSP 90-alpha
- Hamartin
- Stress-induced-phosphoprotein 1
- non-specific serine/threonine protein kinase
- Heat shock cognate 71 kDa protein
- Hsp90 co-chaperone Cdc37-like 1
Sequence:
MAMAEGERTECAEPPRDEPPAEGTLKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQECSKIVKQKAFERAIAGDEHRRSVVDSLDIESMTIEDEYSGPKLEDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM
Protein: Protein-tyrosine kinase (Q92063)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MESRRQVTVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQPNHYQVSGYSGSHGIPAMAGSIYPGQASLLDQTDSWNHRPQEVSAWQPNMEDSGTLDVRGMGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIEREDGGLQGPAGNQHIYQPVGKPDHAAPPKKPPRPGAPHLGSLASLNSPVDSYNEGVKIKPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDESLPVLPASTHREIEMAQKLLNSDLAELINKMKLAQQYVMTSLQQEYKKQMLTAAQALAVDAKNLLDVIDQARLKMISQSRPH
Protein: Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3) (O60512)
Organism: Homo sapiens (Human)
Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Interaction partners:
- Alpha-
- Beta-galactoside alpha-2,6-sialyltransferase 1
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
- Type 2 lactosamine alpha-2,3-sialyltransferase
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
- Beta-1,3-galactosyltransferase 5
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Sequence:
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGSH
Protein: Isocitrate dehydrogenase [NAD] subunit, mitochondrial (A0A087X2E5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU361266}.
Interaction partners:
Sequence:
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKIPSAVPSFLLHPLPFSWAI
Protein: Pumilio homolog 2 (APUM-2) (AtPUM2) (Q9ZW06)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Pumilio homolog 24
- Putative pumilio homolog 22
- Uncharacterized protein
- Pumilio homolog 23
- La-related protein 1A
- Protein EXPORTIN 1B
- Poly
Sequence:
MIPELGRRPMHRGNEDSSFGDDYEKEIGVLLGEQQRRQVEADELERELNLYRSGSAPPTVDGSVSAAGGLFSGGGGAPFLEFGGGNKGNGFGGDDEEFRKDPAYLSYYYANMKLNPRLPPPLMSREDLRVAQRLKGSSNVLGGVGDRRKVNDSQSLFSMPPGFDQRKQHEFEVEKTSASSSEWDANGLIGLPGLGIGGKQKSFADIFQADMGHGHPVTKQPSRPASRNTFDENVDSKNNLSPSASQGIGAPSPYSYAAVLGSSLSRNGTPDPQAIARVPSPCLTPIGSGRVSSNDKRNTSNQSPFNGGLNESSDLVNALSGMNLSGSGGLDERGQAEQDVEKVRNYMFGLQGGHNEVNQHGFPNKSDQAQKATGLLRNSQLRGAQGSTYNDGGGVATQYQHLDSPNYCLNNYGLNPAVASMMANQLGTNNYSPVYENASAASAMGFSGMDSRLHGGGYVSSGQNLSESRNLGRFSNRMMGGGTGLQSHMADPMYHQYADSLDLLNDPSMDVNFMGNSYMNMLELQRAYLGAQKSQYGVPYKSGSPNSHTDYGSPTFGSYPGSPLAHHLLPNSLVSPCSPMRRGEVNMRYPSATRNYAGGVMGSWHMDASLDEGFGSSMLEEFKSNKTRGFELAEIAGHVVEFSSDQYGSRFIQQKLETATSDEKNMVYEEIMPHALALMTDVFGNYVIQKFFEHGLPPQRRELADKLFDNVLPLSLQMYGCRVIQKAIEVVDLDQKIKMVKELDGHVMRCVRDQNGNHVVQKCIECVPEENIEFIISTFFGNVVTLSTHPYGCRVIQRVLEHCHDPDTQSKVMDEIMSTISMLAQDQYGNYVIQHVLEHGKPDERTVIIKELAGKIVQMSQQKFASNVVEKCLTFGGPEEREFLVNEMLGTTDENEPLQAMMKDQFANYVVQKVLETCDDQQRELILGRIKVHLNALKKYTYGKHIVARVEKLVAAGERRMALQSLTQPQMA
Protein: Uncharacterized protein (Q389G4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLSRQLVTRCGMGIRPALINQVSMGCGGVCFTGLRCEKRGVSQIAANLATHALQVPSCFSLSTLLYSPLGTAMLIVLAYNMVVVGTKQMTYIMEITGKDYVQDQQLHQIMKYGILSCLLLAMEVLFVEV
Protein: Flightin (Muscle protein 27) (P35554)
Organism: Drosophila melanogaster (Fruit fly)
Function: Possibly involved in the regulation of flight muscles contraction, possibly by modulating actin-myosin interaction.
Interaction partners:
- FI07231p
- Actin, indirect flight muscle
- Stretchin-Mlck, isoform U
- Troponin C, isoform 1
- Myosin heavy chain, muscle
- GH15296p
- Muscle LIM protein 1
- Cytochrome c oxidase subunit 7A-like 2, isoform A
Sequence:
MADEEDPWGFDDGGEEEKAASTQAGTPAPPSKAPSVASDHKADSVVAGTPANEEAAPEEVEEIKAPPPPPEDDGYRKPVQLYRHWVRPKFLQYKYMYNYRTNYYDDVIDYIDKKQTGVAREIPRPQTWAERVLRTRNISGSDIDSYAPAKRDKQLIQTLAASIRTYNYHTKAYINQRYASVL
Protein: Uncharacterized ubiquitin-like protein C800.12c (Q9HGL0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSEVQIVKSFLEELSKTPRNHPDSIPIEKIDETAISITIPAPLVEFQGNLALFEEKKVHVVAKTVRPPIQQASTEINVQSTILELKEVLASQLSTQPSSIRLMYKGKPLVNSRLLDDYVDADSVSEVNLQMFLMNIS
Protein: Protein phosphatase 1, regulatory subunit 3D (D3ZZ26)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Glycogen [starch] synthase, liver
- Glycogen [starch] synthase, muscle
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Protein phosphatase 1 regulatory subunit 3A
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Protein phosphatase 1 regulatory subunit 3B
- Protein phosphatase 1 regulatory subunit 3C
- Protein phosphatase 1 regulatory subunit 3E
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Sequence:
MSKGPDSALLPSTPGPRKLAPRSLSCLSDMDGRSCRPPGCDPRLRPIIQRRSRSLPTSPERRAKAAGAQGAACGAGCNRQVRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLQCLVPDFQPPIEVPGFGDRLARQLVCLERVTCSDLGISGTVRVRNVAFEKQVTVRYTFSGWRSAHEAVARWRGPAGGEGTEDIFAFGFPVPPFLLELGSQVHFALRYGVAGAEYWDNNDGQDYSLTCRSHALHMPRGECEESWIHFI
Protein: Protein CIMAP1C (Ciliary microtubule associated protein 1C) (Outer dense fiber protein 3-like protein 1) (Q8IXM7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKLPKGTRSSVYFAQHPEKEPLPSRQEVKQTPVIMAKIKGPGPAKYLRPSCTGYIDHDISMFKAPAYTLHSRHSEKRMVCHSSPGPCYLLDPKITRFGMSSCPQVPMEERISNLRLNPTLASCQYYFEKIHPPGERRAPQYTFGYRRPYRVMDLNPAPNQYQMPLLLGPNTPVSRAAPCYSLASRDKNWFYKEDVAGGPGPTTYARPEPSIYQNRSPTYSMAKRFAYPLDLTPRPGPGSHEVQQVTVHKPHIPAFTMGIKHSLHLCPLVIDIRD
Protein: RNA-binding motif protein, Y chromosome, family 1 member C (P0DJD4)
Organism: Homo sapiens (Human)
Function: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:9108067}.
Interaction partners:
Sequence:
MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAQKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY
Protein: Dilute domain-containing protein (B0G181)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MPLKIFNKKGGNNQYTVKLKIDLISNVSYAYPKDTEFEIEWKRGVHRGVLPNVYMQSDGDIKPSTQFLIPCQFLKQKSDQGGEEFAPKSLIVNLRKVESKKKTTKIATLQIDLSHMANKLESDKEKQYSSTMKGIIDQEFKPYIEFTTSVYKGLLSPEDFNDKSVFIAPINVSPPIDDTSISHSLYSDGRRNSVSSVSSELSEYSNIQETSSSIGFGNNNNGNKKDHKRSNSNGSNNSRGSNSSKGSNGSNGINGGNQKKISPTSRHQRSTSDPFEFNFESTTPVTFSRKSLRNSTTLDDDPLNSPSDQPIFSSDEEVKESNNLNNNNISPTNYSNRSISPTNSTQSLETFDKDIENQPTLAETPTKSKKKMFSFSSKKKSKASPESNQRKNSKPENLNVSKIKGDEISTEEFSSGSESGGSPKPGKWKRRHSTPNVGFFSIKSFKDKEKQKEKEKEKEKEKKLQSDFYNTNQTLDNLTINETNENEFEGHHNGLDNNNNSNSNNNNNNNNNNSSMNNENSSKNNKKSKNKKQSFDSNSSTSPTNKQEKSKDRKNSKEKNFINKLTTSLNPNSSNNNNNNNNINNSNGSDSKDTLQSSLVTRHLDEKLKFLIDDMIVSKRPEYVGNIPISAIAIYKCIFEWKELSPNNNKCLTEMIETFDLMIKKKNIGKEKSFYWLSNSFTLGFLLEKSYENQKISRSEFNTSPSINFSHNTESQNLKLLINIVQGYQRSFWSLYWDSVKLELSKVMDRLTEQLRVKEFETTPIFLNFLLSTLEFLEKRLPFQSVWPNIFKQIFFYVSGYLVNKFLTDNSLATTNNAVNTKLFISSLSQWFQENKELNYFYYFKMEMSTLVQILDVLVIDKDSLKDELVRKEICPSLTTTQLAIVLCRFNPENSSEEVDPAVIKYLQDEGIRKHDIQNITTNLDKIYELPDKPEPSRSIIDTKIPLNIFPQSNQKLFKFLTKPTTIY
Protein: Large ribosomal subunit protein uL1y (60S ribosomal protein L10a-2) (P59230)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS21z
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL3z
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL6z/uL6y
Sequence:
MSKLQSEAVREAITTIKGKSEEKKRNFVETVELQIGLKNYDPQKDKRFSGSVKLPHIPRPKMKICMLGDAQHVEEAEKMGLSNMDVEALKKLNKNKKLVKKLAKSYHAFLASESVIKQIPRLLGPGLNKAGKFPTLVSHQESLEAKVNETKATVKFQLKKVLCMGVAVGNLSMEEKQLFQNVQMSVNFLVSLLKKNWQNVRCLYLKSTMGPPQRIF
Protein: Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) (Q3YMT4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
Sequence:
MGVASMLQIDEMLGDFNRMNKRQSLYQVLSFAMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNYKEEPVRVGEIVVFKVEGRDIPIVHRVIKLHEKEDGSVKFLTKGDNNNVDDRGLYAPNQLWLTKKDIVGRARGFLPYVGIITIFMNEYPKVKWAILSILAIFVLLHREI
Protein: N-acetylglucosaminyltransferase (EC 2.4.1.-) (F8KEJ1)
Organism: Limosilactobacillus reuteri subsp. suis (strain ATCC 53608 / LMG 31752 / 1063) (Lactobacillus reuteri)
Function: Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] resulting from the first glycosylation step.
Interaction partners:
Sequence:
MEGLSLTVHITNLYGQSFQSTAQIAQNQIAKIGRELGFNELGIYNYNWPDEPSVALDTRFDGIIASVSNNDTVIFQSPTWNSIEWDQAFIDHLAPYNVKKIIFIHDIIPLMFESNRYLLPQFIDYYNKADLIIAPSQPMVDFLRANGLTVEKVVLQHMWDHCASVDFTVTLQNTGVINFAGNLEKFQLVGHWHYPDNPLYAFAKVIDVEPTDNIKFMGWQSDPVLLSKLRHNGGFGLVWSNEPYCKNYMHLNANHKLSTYLAAGLPVIVNENIAESETILRKGLGIVADNLDEAIEKVQGMDDQSYNEMVQRVDDFARLIREGYFAKKALTEAVFKLYYQ
Protein: Erythromycin C-12 hydroxylase (EC 1.14.13.154) (Cytochrome P450 113A1) (CYP113A1) (Erythromycin D C-12 hydroxylase) (P48635)
Organism: Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Function: Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.
Interaction partners:
- Cytochrome P450 family protein EryCII
- Erythromycin 3''-O-methyltransferase
- 3-alpha-mycarosylerythronolide B desosaminyl transferase
- 6-deoxyerythronolide-B synthase
- 6-deoxyerythronolide-B synthase
- 6-deoxyerythronolide-B synthase
- 6-deoxyerythronolide-B synthase
- Non-ribosomal peptide synthetase
- Non-ribosomal peptide synthetase
- Non-ribosomal peptide synthetase
Sequence:
MTTIDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHADVQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADAGESFDLVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLAGSSPRQSA
Protein: V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) (P39942)
Organism: Bos taurus (Bovine)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9Y5K8}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32764564}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y5K8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Y5K8}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q9Y5K8}.
Interaction partners:
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit F
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit d 1
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit E 1
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase subunit H
- V-type proton ATPase subunit G 2
Sequence:
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNRIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSDKDLEQRRAAGEVIEPANLLAEEKDEDLLFE
Protein: Rac-like GTP-binding protein RAC9 (Q41254)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with the membrane when activated.
Interaction partners:
- Protein LOL2-like
- Protein LOL2-like
- Kinesin-like calmodulin-binding protein
- Kinesin-like calmodulin-binding protein
- Protein TIME FOR COFFEE-like
- Guanine nucleotide exchange factor SPIKE 1-like
- Guanine nucleotide exchange factor SPIKE 1-like
- Protein NAP1-like isoform X1
- RING-type E3 ubiquitin transferase
- RING-type E3 ubiquitin transferase
Sequence:
MNTSRFIKCVTVGDGAVGKTCMLISYTSNTFPTDYVPTVFDNFSANVVVDGSTVNLGLWDTAGQEDYNRLRPLSYRGADVFLLAFSLISRASYENVHKKWIPELRHYAPNVPIVLVGTKLDLRDDKQFLSDNPGAISITTSQGEELKKMIGAVTYIECSSKTQQNVKAVFDVAIKIALRPPKPKRKPIKRRSCAFL
Protein: RCG56007, isoform CRA_c (TIA1 cytotoxic granule-associated RNA binding protein) (Q5PQR7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ras GTPase-activating protein-binding protein 1
- ELAV-like protein 1
- Nucleolysin TIAR
- U1 small nuclear ribonucleoprotein C
- Eukaryotic translation initiation factor 4E
- Ataxin 2
- 5'-
- RCG31562, isoform CRA_c.
- Eukaryotic translation initiation factor 3 subunit B
- Polyadenylate-binding protein 1
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPGNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFIRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPPAYGQWGQWYGNAQQIGQYVPNGWQVPAYGMYGQPWSQQGFNQTQSSAPWMGPNYSVPPPQGQNGGMLPNQPAGYRVAGYETQ
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q6DG42)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDNGELEDKPPAPPVRMSSTFSTGIKDSMSTNPSSKPLPSVPEEKRDKPRNKIISIFSAEKGRKKDKDKERPEISNPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNSRQKYLSFTDKDAPQAKKGSEQSPVKDPDDDDEDAPPPVVAPRPQHTISVYTRSVIDPIPAPAAIADTDGSKAADKQKKGKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAAKEAMKSNR
Protein: Centromere-binding protein 1 (CBP-1) (Centromere promoter factor 1) (Centromere-binding factor 1) (P17106)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters. DNA-binding activity is enhanced by MET28. Required as an auxiliary factor for transcriptional activation of sulfur metabolism together with MET4 and MET28.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Mitochondrion {ECO:0000269|PubMed:14576278}. Chromosome, centromere {ECO:0000269|PubMed:2185892}.
Interaction partners:
- Transcriptional activator of sulfur metabolism MET4
- Transcriptional activator of sulfur metabolism MET28
- Transcriptional regulator MET31
- Histone H3-like centromeric protein CSE4
- Centromere DNA-binding protein complex CBF3 subunit A
- Centromere DNA-binding protein complex CBF3 subunit B
- Transcriptional regulator MET32
- Centromere DNA-binding protein complex CBF3 subunit C
- Suppressor of kinetochore protein 1
- Phosphate system positive regulatory protein PHO4
Sequence:
MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLLSQESNDGNIDSALLSEGATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYTDLIQGQEDSSDAHTSNQTNANGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLIPLAEHDRGPEHQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDEWKKQRKDSHKEVERRRRENINTAINVLSDLLPVRESSKAAILACAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANEKLQEELGNAYKEIEYMKRVLRKEGIEYEDMHTHKKQENERKSTRSDNPHEA
Protein: Thymosin beta 15b like (Q8C0W0)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Actin, cytoplasmic 2
- Myosin XVIIIb
- Cytospin-A
- Unconventional myosin-If
- F-actin-uncapping protein LRRC16A
- Mitogen-activated protein kinase kinase kinase 1
- Thymosin beta
- CD2-associated protein
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 3
Sequence:
MSDKPDLSEVETFDKSKLKKTNTEVKNTLPSNENKMSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT
Protein: Cystatin-9 (Cystatin-like molecule) (Q5W186)
Organism: Homo sapiens (Human)
Function: May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:12535658}. Note=May be targeted through the Golgi via the secretory pathway. {ECO:0000269|PubMed:12535658}.
Interaction partners:
- Cystatin-8
Sequence:
MSSPQRRKAMPWALSLLLMGFQLLVTYAWCSEEEMGGNNKIVQDPMFLATVEFALNTFNVQSKEEHAYRLLRVLSSWREDSMDRKWRGKMVFSMNLQLRQTVCRKFEDDIDNCPFQESLELNNVRQGISFPQVHSCGCCMGCGVGTGAADKAIPRDKGK