wanglab/gogpt-training-data huggingface dataset:
Protein: Talin-A (Filopodin) (P0CE94)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Actin-binding protein that may be involved in the control of cell motility and chemotaxis.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000250}.
Interaction partners:
Sequence:
MSISLKINIVGANTVKTLRFAPDMCIQECCTHIFEKTNEGGPDHGLYQAHIEGKQSARWLAMEKTLQFYDINSDQQLDYKKKHRPQKFKLLDGTIKTQLVDESQNVSEIVNSICKKMGIKNPEEYSLMNSAGAWLNNTQILSEQGISENDITVLMKKFFFNDANIDRNDPVQLHLLFVQCRDGIIEGKYPTQREESLALSALQCQVQLGDYNPTKHVPGFLTLKDYLPLQWLKSKGVEKDIFKEHKKLVSMTEVNAKYRYVQLCRSLKTYGMTSFDVKIREYGKKKMVDHILGITREQMLLMLTETKEVIMTHPLKHIKRWAATDKSFTLDFGDHETEYLILQTPNPEQISQLIGGYIEIIMKARKDSSKVIEKEDTAMGVEEVMAVKKGSVANSSSYMGYGAGGGGANQLQPSQQIPITDLKSALRATDLLIGELGGFRSSTGATPQNFTRSFTTLTPQQFKHQLISHTNAMAIAAQGLFQDMTTPPPTGGIAAFQQAITKRAQIIMAELNTVGTAAKNAGYFPDMASFSDEIIGVATKLSESMARLLAIGSTIQGTDCDEKSQKAAQTEIFNVQSLVTLMMAACDNEYVTDSSSKLLIECAKNVSAAIADMLVVGNSKVEFIDDELLLGQIQNTLKSTSLTSDELLSTTENLASTSCHPESRKQITNITQSALNQSNALLTAFKSGEIPEQDYNLLNARVSDIIESVNLINYAMDCSEREYKISITSNGVEVGEGEILAGTNLTEEFATVANDLTNAIMTMRSNLKNPDTVMESYKMVAGHANRLITCTKAVASRADTQSQQRLFNSTNAVFESVANLSNHCRSYIKNPEQEAHTFQIVETAGHLQFLTQNMSTDAGKIACITSLRDYSKEMIAQVSSLISTSRTSSQYLPDANGITLLKGAKDVSDALSKLMVGIKKVVLDPKSEATQMELLTLAQKQSLPPMNLVSTCKRFAPKISDPNQKQRLIFSSDAAAQSVQKLMKAGEAYKRICGHIEIEEALEVFDSTIADLETTEIAIAGGFLDAVSGTTREGAAELLMVAIKDLNKVNNELVTDIRVNPARLGDLVKSATESASSVAISAKTLICATTGKQVQKKLMGITKQLMIDMEQLIRASRSVASNPNDAASELLLDAASNDVSISTAALVGSTANVDCKELDEASADISNLLSLKMGSLESILSQPTEEFAFYVEEIASSTKALNAASQQVVAMARNKNLKGLGASAKITASALSTLVSHAQNAIVLTENEATKNAILASTVALGGQIIGLLDFSKARIANY
Protein: Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B) (Q8CG70)
Organism: Mus musculus (Mouse)
Function: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
Subcellular location: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Decorin
- Cartilage-associated protein
Sequence:
MLRLLRLLLLLLLPPPGSPEPPEPPGLAQLSPGSPPQAPDLLYADGLRAYSAGAWAPAVALLREALRSRAALGRARQECGASCAAEPGAALPSQLLGAPHPVSGPGVWEPLLLRATLRRAECLTQCAVRRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAASAAHTFFVANPTHLQMREDMAKYRRMSAIRPQSFRDLVTPLYWAAYDTGLELLEQREAALALPQLEEALQGSLAHMESCRAACEGPEEHQGAEEEGEGSQGGLYEAIAGHWIRVLQCRQHCVADTATRPGRSFPVQDFLLSQLRRLHEAYAQVGNMSQAMENVLSVLLFYPEDEAAKKALNQYQTQLGEPRPDLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDSWTPEALIPKALRERLREDQEKKPWDHQPPQQKPLAHWKDALLMEGVTLTQDAQQLNGSERAVLDGLLTSAECGVLLQLAKDAAQAGARSGYRGRRSPHSPHERFEGLTVLKAAQLARAGTVGRPGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFKGGDLFFTQPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHSEQEWTEAKELLQEEEEEEEEEDILSRDPSPEPPSHKLQRVQEKAGKPRRVRVREEL
Protein: RNA-binding protein, putative (Q583K0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- CSN8/PSMD8/EIF3K domain-containing protein
- Translation initiation factor, putative
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit 8, putative
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit E
- Elongation initiation factor 2 alpha subunit, putative
- Eukaryotic translation initiation factor 5, putative
- Eukaryotic translation initiation factor 3 subunit I
Sequence:
MATWADDMEPIALGEDFGGNQLTPQEAKALADKEAAWKNAKVVTETITDAENKQYEIVKRVLQYRVDREATPVDVRAKWKRFGRATNPADQKDLVSRDPPIVLELGEVDPFERMAREEVMRLMNEVERYTVEVKDVHLARYAKVKEEQERAAKEAAAPDDQGKERTWAAARGDKTSVQHKEDTDRRLRITNISDDISREELYNIFNTDEYRIDKLFLPTDGKTSNYRGFAFITFETPEQAERCLSRTKGVARFKNTVMHIVRALPEGAKQRN
Protein: Cone-rod homeobox protein (O43186)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Neural retina-specific leucine zipper protein
- Photoreceptor-specific nuclear receptor
- Rhodopsin
- Aryl-hydrocarbon-interacting protein-like 1
- Ataxin-7
- Recoverin
- Tetra-peptide repeat homeobox protein 1
- Retinal guanylyl cyclase 1
- Retinoid isomerohydrolase
- Flt3-interacting zinc finger protein 1
Sequence:
MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL
Protein: Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP) (P97953)
Organism: Mus musculus (Mouse)
Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Subcellular location: Secreted.
Interaction partners:
- Vascular endothelial growth factor receptor 3
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Neuropilin-2
- Vascular endothelial growth factor D
- Lymphatic vessel endothelial hyaluronic acid receptor 1
- Neuropilin-1
- Platelet-derived growth factor receptor beta
- Angiopoietin-1 receptor
- Platelet-derived growth factor receptor alpha
Sequence:
MHLLCFLSLACSLLAAALIPSPREAPATVAAFESGLGFSEAEPDGGEVKAFEGKDLEEQLRSVSSVDELMSVLYPDYWKMYKCQLRKGGWQQPTLNTRTGDSVKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGAATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTGYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYVWNNYMCRCLAQQDFIFYSNVEDDSTNGFHDVCGPNKELDEDTCQCVCKGGLRPSSCGPHKELDRDSCQCVCKNKLFPNSCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTENTQKCFLKGKKFHHQTCSCYRRPCANRLKHCDPGLSFSEEVCRCVPSYWKRPHLN
Protein: Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) (P19823)
Organism: Homo sapiens (Human)
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Subcellular location: Secreted.
Interaction partners:
- Protein AMBP
- Alpha-2-HS-glycoprotein
- Beta-2-glycoprotein 1
- Prothrombin
- Inter-alpha-trypsin inhibitor heavy chain H1
- Albumin
- Fibrinogen alpha chain
- Apolipoprotein A-I
- Apolipoprotein B-100
- Inter-alpha-trypsin inhibitor heavy chain H3
Sequence:
MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGESEEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVISKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSKVVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGLQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP
Protein: Sphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2) (Protein two of hearts) (A2SWM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate, which play critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19074308}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:19074308}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Membrane-bound transcription factor site-1 protease
- Sphingosine 1-phosphate receptor 2
Sequence:
MCVESDGCEIEGCSSSDEVHTLSGSMSPALKSRDLHHCRPGQKFHAALLRCRTPLVAAGILSFGNVLNYMDRYTVAGVLLDIQKQFKVGDSSAGLLQTVFICSFMVAAPIFGYLGDRFNRKIILSCGIFFWSAVTLLSSFITKEYYWLLVLSRCLVGIGESSYSSISPTIIGDLFTNNKRTVMLSVFYLAIPLGSGLGYILGSIAKDAGGHWYWALRVSPMLGLTAGTLILIFVSEPKRGSADQPGGRLKTRTSWVCDMKALAKNRSYVFSSLASAAVSFATGAFGIWIPQYLVRAQVVQKSAESCTYQPCSSRDSLIFGAITCVTGLLGVVIGAVTTRLCRQKTERADPLVCAVSMLGSAIFICLIFVVAKKSIVGAYICIFIGETLLFLNWAITADILMYVVIPTRRATAVAFQGFTSHLLGDAGSPYLIGLISDSLQESYATSEIWQFLSLGYALMLCPFVIVLGGMFFLATALFFLDDRDKAAKQVNQLARPPSTVKVTK
Protein: AT5g08190/T22D6_130 (DR1-like protein) (Nuclear factor Y, subunit B12) (Q944I5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g12480/MQC3.32
- DNA polymerase II subunit B4
- AGAMOUS-like 98
- Histone superfamily protein
- TATA-binding protein-associated factor BTAF1
- TATA-box-binding protein 2
- TATA-box-binding protein 1
- Protein EARLY FLOWERING 5
- Nuclear transcription factor Y subunit C-4
Sequence:
MDPMDIVGKSKEDASLPKATMTKIIKEMLPADVRVARDAQDLLIECCVEFINLISSESNEVCNKEDKRTIAPEHVLKALQVLGFGEYVEEVYAAYEQHKYETMQDSQRSVKMNSGAEMTEEEAAAEQQRMFAEARARMNGGVTVPQPEQLEEPQQQQQTSLQS
Protein: Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Q63528)
Organism: Rattus norvegicus (Rat)
Function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P15927}. Nucleus, PML body {ECO:0000250|UniProtKB:P15927}. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. {ECO:0000250|UniProtKB:P15927}.
Interaction partners:
- Replication protein A 14 kDa subunit
- Replication protein A subunit
- RecQ-like DNA helicase BLM
- RecQ-mediated genome instability protein 1
- DNA polymerase alpha catalytic subunit
- DNA polymerase delta catalytic subunit
- DNA primase large subunit
- DNA polymerase delta subunit 2
- DNA topoisomerase
- Replication protein A 14 kDa subunit
Sequence:
MWNSGFESFSSSSYGAAGGYTQSPGGFGSPTPSQAEKKSRARAQHIVPCTISQLLSATLTDEVFKIGDVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMDVRQWVDTDDTSGENTVVPPETYVKVAGHLRSFQNKKSLVAFKIIPLEDMNEFTAHILEVVNSHLMLSKANSQASVGRPSMSNPGMGEPGNFSGNNFMPANGLTVVQNQVLNLIKACPRPEGLNFQDLRSQLQHMPVASIKQAVDFLCNEGHIYSTVDDDHFKSTDAE
Protein: Protein KRE1 (P0CY22)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in cell wall 1,6-beta-glucan assembly possibly by the addition of linear side chains of 1,6-linked Glc units to a highly branched 1,6- and 1,3-linked glucan backbone.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Nucleoporin NSP1
- Skn1p
- Kre9p
Sequence:
MNVNSVIYYILFLFASTILAADKTSSSVSPTLVWVTGTDANGKLATTQSTYYQSFMSTYTTAETPSSGSIGLGSISGTVGEIRTYSMTTISQGNGGLSKFNQNGLEMKNLSFVKLIGVSFIAFISFILLI
Protein: Dolabradiene monooxygenase (EC 1.14.14.159) (Cytochrome P450 71Z16) (ZmCYP71Z16) (A0A1D6GQ67)
Organism: Zea mays (Maize)
Function: Involved in the production of antifungal dolabralexin phytoalexins in response to biotic and abiotic stresses. Catalyzes the epoxidation of dolabradiene at C-16, followed by hydroxylation at C-3, to yield the epoxides 15,16-epoxydolabrene (epoxydolabrene) and 3b-hydroxy-15,16-epoxydolabrene (epoxydolabranol).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Dolabradiene synthase KSL4, chloroplastic
- Ent-copalyl diphosphate synthase 2, chloroplastic
- ABC transporter G family member 34
- ABC transporter G family member 34
- ABC transporter G family member 34
- ABC transporter G family member 34
- ABC transporter G family member 34
- ABC transporter G family member 34
- ABC transporter G family member 34
Sequence:
MEDKVLLAVAMVALIAVLSKLKSLLETKPKLNLPPGPWTLPLIGSIHHLVSSPLPYRAMRELAHKHGPLMMLWLGEVPTLVVSSPEAAQAITKTHDVTFADRHMNSTVDILTFNGNDIVFGTYGEQWRQLRKLSVLELLSVARVQSFQRIREEEVARFMRNLAASAGAGATVDLSKMISSFINDTFVRESIGSRCKHQDEYLDALHTGIRVAAELSVANLFPSSRLLQSLSTARRKAVAARDEMARILGQIIRETKEAMDWGDKASNESMISVLLRLQKEAGLPIELTDDIVMALMFDLFGAGSDTSSTTLTWCMTEMIRYPATMAKAQAEVREAFKGKTTITEDDLSRANLSYLKLVVKEALRLHCPVPLLIPRKCRETCQIMGYDIPKDTCVLVNVWAICRDSRYWEDADEFKPERFENSSLDYKGTSHEYLPFGSGRRMCPGGNLGVANMELALASLLYHFDWKLPSGQEPKDVDVWEAAGLVGRKNAGLVLHPVSRFAPVNA
Protein: Protein SICKLE (Protein ROTUNDA 3) (Q9SB47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in miRNAs and siRNAs biogenesis and thus promotes gene silencing. Modulates auxin (IAA) transport-related developmental programs by regulating protein phosphatase 2A (PP2As)-driven auxin efflux carrier PIN proteins recycling and polarity. Required during development. Necessary for abiotic stress (e.g. chilling and salt) tolerance.
Subcellular location: Nucleus {ECO:0000269|PubMed:23071326, ECO:0000269|PubMed:26888284}. Cytoplasm, cytosol {ECO:0000269|PubMed:26888284}. Note=Colocalizes with miRNA biogenesis components in distinct subnuclear bodies (PubMed:23071326). Localized in the nuclei, excluding the nucleolus, in all cells of the root apical meristem. In young cortical cells of the root, localized in the nucleus and cytosol (PubMed:26888284). {ECO:0000269|PubMed:23071326, ECO:0000269|PubMed:26888284}.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS21y
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS28x
- Large ribosomal subunit protein eL38z/eL38y
- Small ribosomal subunit protein eS28z/eS28y
Sequence:
MEDSEKRKQMLKAMRMEAAAQNDDDATTGTETSMSTGHLSNPLAETSNHQQDSFETQRFDYYTDPMAAYSSFKKNKTPKQQYISSPSHQGSSPVPPQFPPSVPPGSLCSEYQAQTNHGGFHAAHYEPRGMAHLSPSHRGPPAGWNNNFRPPPVNHSGPPQWVPRPFPFSQEMPNMGNNRFGGRGSYNNTPPQFSNYGRQNANWGGNTYPNSGRGRSRGRGMNTSFGRDGGRRPMEPGAERFYSNSMAEDPWKHLKPVLWKNCSDASSSSSTGQAWLPKSIAPKKSVTSEATHKTSSNQQSLAEYLAASLDGATCDESSN
Protein: Inactive S-adenosylmethionine decarboxylase prozyme (AdoMetDC prozyme) (A5HNV6)
Organism: Trypanosoma brucei brucei
Function: Probably has no catalytic activity due to the loss of several residues required for processing and catalysis. Forms a complex with S-adenosylmethionine decarboxylase AdoMetDC which is essential to activate AdoMetDC. Required for the biosynthesis of the polyamine spermidine. Required for growth and survival during the bloodstream life cycle stage.
Interaction partners:
Sequence:
MSVTRINQQTECPSSVHDLVSCWGGCTQSKTSTDSGLEKRFELNFAQPVDIGTVTVKQLASVMERAGESLRQNSAELGIHTLKFDRSLLVFTAKQIVVRSSVSVMLHEAVHPMLELMRSHNIIVDWASFMRVNYGSPWDMTSETSDIMAHEYAELKSAFPTGHPYLAGPVDRDHCFYFVYDGIDRDPSSCRRENDVQINVYMYNVQADDEYDLDGNTKEQQLLVSHCAGEYETLRVSTYGSTHPFASFETNAVSAASDITKIVNGLLKKFYPERVLLVLLQDRDAQGTTACGVMDRLEGFTVVHRGANHFGGGYVFHQATYARSA
Protein: UPF0056 inner membrane protein MarC (P0AEY1)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MLDLFKAIGLGLVVLLPLANPLTTVALFLGLAGNMNSAERNRQSLMASVYVFAIMMVAYYAGQLVMDTFGISIPGLRIAGGLIVAFIGFRMLFPQQKAIDSPEAKSKSEELEDEPSANIAFVPLAMPSTAGPGTIAMIISSASTVRQSSTFADWVLMVAPPLIFFLVAVILWGSLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGILEIIKTYH
Protein: Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) (Q8N960)
Organism: Homo sapiens (Human)
Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:36590171}. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo. {ECO:0000250|UniProtKB:Q7TSG1}.
Interaction partners:
- Spindle and centriole-associated protein 1
- Protein TALPID3
- Pericentrin
- Cytoskeleton-associated protein 5
- Transforming acidic coiled-coil-containing protein 3
- Transforming acidic coiled-coil-containing protein 1
- Centrosomal P4.1-associated protein
- Centlein
- Centrosomal protein of 135 kDa
- Centrosomal protein of 290 kDa
Sequence:
MVSKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKALHQHRLQRTPIKLQCFALDPVTSAKETIGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKSEIQISIALETDTKPPVDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVTIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLCCGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQREGIDSQSLIELKTQNEHEPEHSKKKVLTPIKEKTLTGPKSPTVSPVPSHNQSPPTKDDATESEVESLQYDKDTKPNPKASSSVPASLAQLVTTSNASEVASGQKIAVPATSHHFCFSIDLRSIHALEIGFPINCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFLGSNGEQCWRQTYSESVPVIAAQGSNNRIADLSYTVTLEDYGLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILAKSNASN
Protein: Kinesin-like protein KIF7 (Q2M1P5)
Organism: Homo sapiens (Human)
Function: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity).
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19592253}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:B7ZNG0}. Note=Localizes to the cilium tip.
Interaction partners:
- Suppressor of fused homolog
- Zinc finger protein GLI2
- Zinc finger protein GLI1
- Transcriptional activator GLI3
- Protein smoothened
- Tubulin beta-2B chain
- Tubulin alpha-1A chain
- Serine/threonine-protein kinase 36
- Kinesin-like protein KIF3A
- Protein patched homolog 1
Sequence:
MGLEAQRLPGAEEAPVRVALRVRPLLPKELLHGHQSCLQVEPGLGRVTLGRDRHFGFHVVLAEDAGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLLEDEQGIVPRAMAEAFKLIDENDLLDCLVHVSYLEVYKEEFRDLLEVGTASRDIQLREDERGNVVLCGVKEVDVEGLDEVLSLLEMGNAARHTGATHLNHLSSRSHTVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHFVDLAGSERVLKTGSTGERLKESIQINSSLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERPPEETASGARGPPRHRSETRIIHRGRRAPGPATASAAAAMRLGAECARYRACTDAAYSLLRELQAEPGLPGAAARKVRDWLCAVEGERSALSSASGPDSGIESASVEDQAAQGAGGRKEDEGAQQLLTLQNQVARLEEENRDFLAALEDAMEQYKLQSDRLREQQEEMVELRLRLELVRPGWGGPRLLNGLPPGSFVPRPHTAPLGGAHAHVLGMVPPACLPGDEVGSEQRGEQVTNGREAGAELLTEVNRLGSGSSAASEEEEEEEEPPRRTLHLRRNRISNCSQRAGARPGSLPERKGPELCLEELDAAIPGSRAVGGSKARVQARQVPPATASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQHSQRIRELEQEAEQVRAELSEGQRQLRELEGKELQDAGERSRLQEFRRRVAAAQSQVQVLKEKKQATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQRRLREETEQKRRLEAEMSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQSQQQIRGEIDSLRQEKDSLLKQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYWLEVALERQRLEMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQYEARIQALEKELGRYMWINQELKQKLGGVNAVGHSRGGEKRSLCSEGRQAPGNEDELHLAPELLWLSPLTEGAPRTREETRDLVHAPLPLTWKRSSLCGEEQGSPEELRQREAAEPLVGRVLPVGEAGLPWNFGPLSKPRRELRRASPGMIDVRKNPL
Protein: SH3 domain-containing protein (Q8MPT2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSVYEKQRSSSFGDNTQQMYAMAQHHHQTMGASPRKFNITDGLRSFHKASAFLPGFVVDNCNAQLDDIGFEFVQQCIDILEESGIHEQGVYRNCGVTSKVQKMMMLGLDRRKASEKGGLNLRDDEWETKTISSAVKTFLRNLPEPLMTFELHNVFINAAKMGDATMRIDHIHFYVHQLPAQHLRMLEIVVRHLKRVADLSNENLMTVSNLGVCFGPTLLRPKEETVAAIMDIKFCNVVVEVLISNYDKIFKSKPKSSFGSAVPPKPDHHTSYDNGRPLATRSFGVGSKIVRSTQVVSSSYSRGMQKRDAMYPSEIARHGIGFDVGELGDFQIENNRSPLTSPTGIAPLASGSIEEIDEVAKKERNSSDSLNSLGSFGSVGDESTATVVAAPDGFGKSIVKPKYSVSYASTYNRIPADSRRVKTLYACTPDHHSELSFEPGQIITNVYESNEDGWLVGTLNGKTGLIPSNYVEPLP
Protein: Cytochrome b5, putative (Q57XJ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFDYLLSLLGLLKEWPQYTLDDVRKHNDRHSLWIVAGNSVYDVTSILDSHPGGANALLQRGGGVKDCTNDFGYHSRAAQAVWASLKVGEVRFDSSEERSPLGLASALKEESKSSSKPVSPLIQMCDMKVCNSKGGCCRTSTVESHIGTSEFVPECHCADCFHRRRISGKGTASCSGAKSS