Protein: Dynein-1-beta heavy chain, flagellar inner arm I1 complex (1-beta DHC) (Dynein-1, subspecies f) (Q9MBF8)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.
Subcellular location: Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Interaction partners:
Sequence:
MEPGDEGKGHQLTADATCIAWVRSKLQLLKPESLGDSDGAEWLSSVWHNDVHTPVVSTFLMSVKATRMFAALDGGHEGGSSPKLVLALEVPKQFEQMVYFVRDPSKFVTRENVGSVIFFGVMRGGDPLHSLLNIMHGLYVPVVVANTTWPETVKSDFTAQMHKFMANLTETVYEVKGKTILYIPQEDLRDPKAAAKQKDLVQRLESTIIHWTRQVKELLNQQDSVDASEQAGPLAEIEFWRERSVDLSGIRAQLDDGAVSSIVSVLEYAKSSYLAPFLSLRNLIHREAVAAEDNLKFLLCLEEPCQQLASAHPQTIPSLLPPILNCIRMVWNLSRFYNTPERLSVLLRKLSNEIINRCCSVISLPDVWSGDVDNVMVALRQSMEAGERWKELYKRTAAAVAVRSPKPWDFDISSIFAHIDAFLQRCNDLLEVCEAQLQFAPRTPLPVFGGTYGPEVKKSILDIQESFQGLVQGLQALKYDILDVKATRWHDDFNGFKGGVKDLEVMMANVIQRAFDTQPCLAARGELLEGFQTMAKRDYIRRFVEKKTVEFFALFNAEINTVKKLFDAVKRSQPKSPILPRYAGLAKYAMNLMRRLEQSHKVVDSVRYTLPQVSEAADVMQQYELAHQAIEQYISNTHNDWFSTIESSIAKELQACLLTQDKASGGLLSMNFHKDLLSMGQEVHFWERMRLAVPLVAMEINAQREKYRVLRDNILMVVRDYNKILTALDKEERKLFHDRIRYLDRRIMPGVTKLQWTADKHALEFYYREARKFCRDADMAVGDYKTANSRLDAICRSISELVLVDVEKKKIYQHAEFANLQESHHAKIKDRLVSAVDEIRDIMASIHRVFEQDSEEVQREWVRFTQKVDRKLEDALRHVIKKSLQELSRLLNGDNKTEVMPIFHVTMVLERTNRVELRPTIQALFDTINSVARNLILVLQSVPRVALQLTDKQRRDMEDAGLPLPKPLPTLYETISADEDAVLRTIMQITSGITSIIDKVQAFLTYWEKKYRQVWEADRDAYIRRYEKAQKPLSSFEADISRYLQCIDEIRGEDGATNMRFLRIDCGPLKLTLVGHCEAWVSKFTGLLGQLAATELRTLHTYFRENKDSLMLAPSTLEQLAELVGLHRRLADERRRTEARFEPLRDKYKLLERYEVGAKEEEAALLEGLEPAWTQFQALLDETAGKLERYKDNFREKVKSLLDTFLKDVAQLCEDFSRDAPYSSEVPTPDALDFIQASKQADEDTRKRAAEIKNGMDIFNIPQPQYKDLAAMEKDLDFLDRIWGLKDEWEQLYYGWKDGSFTDIKVEEMEEAAVRIGKNVAKLGRDIRQWTVWSSLKDTLDAFKRTMPLITDLRNPAMRPRHWQNLQDHIGVRFDPHSRDFTLDSLVALRLDQHVEFVAELSVNATKELAIENNIKAIAATWSALGLDMAEYKSTFKLRSTEEIFTSLEENIVTLSTMKASKYFIVFEKDIAYWEKTLSHISETIEIILQVQRNWMYLENIFIGSEDIRKQLPQESQMFDAVHNNFMRLMKQLYSTANCLKACTAQGLLESFQDMNNKLERIQKSLDNYLENKRQQFPRFYFLSSDDLLEILGQAKDPLNVQPHLKKCFEGIKKLDMHLPGEDRKQTISVGITSPDGEYLPFANPVITEGRPEEWLNRVEDAMFLTTKKHLYKVLEESKAQKKEKWVKENQGQMIITAGQIVWTHECEKALADADSARKNLKLLKKKWISYLNKLTAVTRSKLNKIERNKVVALITIEVHARDVIEKLGKSNCSSTNDFEWVSQLRFYWDREKNDCIVKQVLSVFYYGYEYQGNNGRLVITPLTDRCYMTLGAAMFTRRGGNPLGPAGTGKTETVKDFGKALARYVIVFNCSDGVDYKMTGKMFSGLAQTGAWACLDEFNRIEVEVLSVVATQIAAVMQAIKESKKRFLFLGQEIRLNPSCGIFVTMNPGYAGRSELPDNLKAMLRPVSMMVPDFTLIAEIMMFSEGFSSAKVLAKKMIAIMELSQQQLSKQDHYDYGLRSFVIPIARAAGSLKRLDPEGSEEVILYRTMLDLIKPKLVYLDLPLFMALLSDLFPGVELPPADGGSLRRAIEAELRESNLQIVPEFVTKIIQVFDCKVARHGNMIVGRTGSGKSEAWKCLQRALGRLRKEEPDDDRFQKVHVHTINPLALSNDELYGCFEAATHEWQDGVLARIMRTVCKDETHEQKWILFDGPVDTLWIESMNTTLDDNKLLTLLSGERIAMTPAVSLLFEVEDLSQASPATVSRAGMIYLNVEDLGWRPFITSWLAAKQAAPGADAAIIDQVSKLVDKYMEAALEHKRLHCRELVPTDRLSCVRAFTRLWDALAVPENGVGTMPVDESAGPPGSKAAAAAAAAAAAAAPPEETSGGTGGNLVEMWFLFCLIWGIGGPLDEEGRKKFDAFMREMDTRYPSSDTVFEYFVEPKAKSWLAWETKLTGAFKPAMDQPFFKILVPTVDTVRNRFVGSALVRVSQHTLIVGNVGVGKTMIVGSLLEGLPGDRMSSMTINFSAQTSSNSLQDTIEGKLEKRTKGVFAPAGGKRLVCFIDDLNMPQKSKFGFIPPLELLKLWVDNGFWYDRAKCEVKHIKDMQLLAAMAPPGGGRNAFSQRVQACFATLNVTAPNDNQLKRIFGTILNAKLADFDDEVKPLSEPITMATIGIYRAVSKELLPTPSKSHYLFNTRDLAKIIQGMMQATKAFYNSKEEVLQLWCHECMRIIADRMWDHADKEWLVRQLDEKLGTTFSTSFGTLFEAYNETVPPFVTFMRQNVDVPVYEAVRDMVALKDLLTERLEDYALEPGHSAMDLVLFRDALSHVCRIHRILGQPRGNALLVGVGGSGRKSLARLAAFVAELKCFTIEITKNYRQTEFREDLKGLYRQAGVANKPTVFLFDETQIVYETFLEDVNNILTSGEVPNLFPKDELGSVLDELRPAAKAAGAGETADALYGFLLERVRTNLHVVLCLSPVGEAFRERCRMFPGLVNCTTIDWFTEWPADALFEVAQKQLMDVDLGSTEVKTAVCKVFVTAHQSVENTSAKMFAALKRRNYVTPTNYLETVRGYKGLLAEKRTELGEKAAKLQGGLHKLDETSVQVAAMKKVAEEKKVVVAQAKADCEELLVEIVQDKRVADEQEKQVNAEAQKIGKEAEEANIIAAQVQQELDKALPALREAEAALDVLTKKDMSELKAYAKPPEKVEMTLNAVLTVLRRPPNWDEAKKRLSDANFMQSLKEFDKDKLDDSLLKKIGKFTANPDFTYEKINTVSAAASGMCKWVHAMETYGYVAKDVAPKRAKLKSAQDTLARKQAALALAQEQLAVVLAKVQALKDKYDTSIARKQALEEELADLEGKLERAEKLVTGLAGERVRWEASISEYNIALGCLPGDVVVAAAFMSYAGPFPSEYRDELVKHTWLPQVKALNIPASEHFDFALFLANPAMVRDWNIQGLPSDSFSTENGVMVTRGRRWPLMIDPQGQANKWIKNMEGRGGRLKVLNLQMSDMARQIENAIQFGQPVLMQDILQEIDPILEPVLAKSFIKRGNQTLIKLGDKEVDYNFDFRLYLTTKLANPLYTPEISTKVMIVNFAVKEQGLEAQLLATVVKNERPDLDKQKNDLVVKVAAGKRTQAELEDTILHLLSTATGSLLDNVTLINTLDQSKTTWEEVNASLAVAEETQKKIEAASQLYRPCSVRASVLYFVLNDLSTIDPMYQFSLDAYNDLFLLSIKNSPKNDNLAERIKSLNDFHTYAVYKYTSRGLFERHKLLLSLQMCVRILQTANQVNTEEWQFFLRGGTVLDRSSQPNNPSQEWISEEAWDNITELDALPNFKGVVSSFESNLGEWEAWYRKGDPEASELPAEWESKCNELQRLILVRCLRPDRVIFAATTYVSNALGRKYVEPPVLDLAETLKDSTALSPLIFVLSAGVDPTDNLRKLATEKGMTSRFFTVALGQGQAPTATRLIEDGLREGNWVFLANCHLMTSWLPTLDKIIEGFETKQPHENFRLWLSSNPSPSFPIAILQRGIKMTTEPPKGLRANLLRLYNSVSDASYAQCKTQIKYQKLLFALTYFHSVLLERRKFRTLGFNIPYDFNDTDFSVSDDLLKSYLDSYEQTPWDALKYLIAEANYGGRVTDELDRRVLASYLNKFYCEDALAVPGYLLSPLSTYYVPENGPLQSFKDYILTLPAGDRPEAFGQHPNAEISYLIEDSKVLLDSLLSLQPRTEGAAGGAGTRREDVVMAIATDLLDQVPQPFNLEEVMKAKADDPSALHVVLFQEVERYNALLVAVRRSCVELQRGIKGLVVMSADLDLIFESLYAAKVPAAWLKTYPSLKPLGPWTRDLLQRIEQLATWVEETYPRVYWLSGFTYPTGFLTAVLQTTARKASVPIDTLSFEFSIINLDEREINAPPKEGVYIKGLFLEGAGWDFENGCLCEPNPMELIVPMPILLFRPVENKKRTAKGIYTCPLYLYPLRTGTRERPSFMINVDLRSGSADPDHWIMRGTALLLSLAT