wanglab/gogpt-training-data huggingface dataset:
Protein: L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) (P04968)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
Interaction partners:
- Dihydroxy-acid dehydratase
- Acetolactate synthase isozyme 2 small subunit
- Branched-chain-amino-acid aminotransferase
- Acetolactate synthase isozyme 3 small subunit
- Acetolactate synthase isozyme 1 large subunit
- 3-isopropylmalate dehydrogenase
- Threonine synthase
- Acetolactate synthase isozyme 1 small subunit
- Acetolactate synthase isozyme 3 large subunit
- Serine hydroxymethyltransferase
Sequence:
MADSQPLSGAPEGAEYLRAVLRAPVYEAAQVTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLTEEQKAHGVITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDAVRGFGGEVLLHGANFDEAKAKAIELSQQQGFTWVPPFDHPMVIAGQGTLALELLQQDAHLDRVFVPVGGGGLAAGVAVLIKQLMPQIKVIAVEAEDSACLKAALDAGHPVDLPRVGLFAEGVAVKRIGDETFRLCQEYLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIALHNIRGERLAHILSGANVNFHGLRYVSERCELGEQREALLAVTIPEEKGSFLKFCQLLGGRSVTEFNYRFADAKNACIFVGVRLSRGLEERKEILQMLNDGGYSVVDLSDDEMAKLHVRYMVGGRPSHPLQERLYSFEFPESPGALLRFLNTLGTYWNISLFHYRSHGTDYGRVLAAFELGDHEPDFETRLNELGYDCHDETNNPAFRFFLAG
Protein: Acetamidase (EC 3.5.1.4) (P08158)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Allows acetamide to be used as a sole carbon or nitrogen source.
Interaction partners:
- Acetamidase regulatory protein
- Phenylacetate 2-hydroxylase
- Nitrilase
- CN hydrolase domain-containing protein
- Orotidine 5'-phosphate decarboxylase
- ATP-dependent DNA helicase II subunit 1
- Multifunctional tryptophan biosynthesis protein
- 4-aminobutyrate aminotransferase
Sequence:
MPQSWEELAADKRARLAKTIPDEWKVQTLPAEDSVIDFPKKSGILSEAELKITEASAADLVSKLAAGELTSVEVTLAFCKRAAIAQQLTNCAHEFFPDAALAQARELDEYYAKHKRPVGPLHGLPISLKDQLRVKGYETSMGYISWLNKYDEGDSVLTTMLRKAGAVFYVKTSVPQTLMVCETVNNIIGRTVNPRNKNWSCGGSSGGEGAIVGIRGGVIGVGTDIGGSIRVPAAFNFLYGLRPSHGRLPYAKMANSMEGQETVHSVVGPITHSVEDLRLFTKSVLGQEPWKYDSKVIPMPWRQSESDIIASKIKNGGLNIGYYNFDGNVLPHPPILRGVETTVAALAKAGHTVTPWTPYKHDFGHDLISHIYAADGSADVMRDISASGEPAIPNIKDLLNPNIKAVNMNELWDTHLQKWNYQMEYLEKWREAEEKAGKELDAIIAPITPTAAVRHDQFRYYGYASVINLLDFTSVVVPVTFADKNIDKKNESFKAVSELDALVQEEYDPEAYHGAPVAVQVIGRRLSEERTLAIAEEVGKLLGNVVTP
Protein: Protein SOC3 (A0A509AN42)
Organism: Plasmodium berghei (strain Anka)
Interaction partners:
Sequence:
MKNQNDKLDNLKDLAPFYKKDNEKFSENTEDIVYSVKKKFNVIKEKGENTFSKYENTKKNLELLNREQKLNKISLGHQKNEYEDLKSKNEGILNKFENLKHSKYTYQIMLQRIKKEKKMLYFYLNSLERTVKSLKNTEKQHQNIIQKITSENKNLRKSIEDKKMEIIQAKNKNEEILKYMNVNKEHSNILRIRREMINEYKNNKLNNADISLMIQEKKKFKKLLIYYLLYNNYLKLSASSIFENASNIYSTISKMREATGVTDIYDINQKFLDIENKQNLLQKEEALSQKKLEDAIKEYISLNNEIINTFSEDKDIIKEKILYEKEKVSDDIYDLYKLVFASEKELEDINIKLDKIQKFLEKQNKYFYSINMEDKIEFNSNEDMLQYIKNLQNGLEKLMMITQKNREDGNISRSYKSLEFLEIINLYKNVDFHKNMCRVNDAQDLENTIKFESKIITKNPH
Protein: Autophagy-related protein 8 (Autophagy-related ubiquitin-like modifier atg8) (O94272)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Contributes to the maintenance of cell viability under conditions of nitrogen-depletion. Plays a role in meiosis and sporulation and contributes to oxidative stress resistance.
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P38182}; Lipid-anchor {ECO:0000250|UniProtKB:P38182}. Vacuole membrane {ECO:0000269|PubMed:33138913}; Peripheral membrane protein {ECO:0000269|PubMed:33138913}.
Interaction partners:
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 3
- Probable cysteine protease atg4
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy receptor Nbr1
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Putative lipase atg15
- Autophagy-related protein 18
- Autophagy-related protein 9
Sequence:
MRSQFKDDFSFEKRKTESQRIREKYPDRIPVICEKVDKSDIAAIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFIDEILPPTAALMSTIYEEHKSEDGFLYITYSGENTFGTVFPF
Protein: Elongation factor Tu, mitochondrial (tufM) (P02992)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
Interaction partners:
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS6m
Sequence:
MSALLPRLLTRTAFKASGKLLRLSSVISRTFSQTTTSYAAAFDRSKPHVNIGTIGHVDHGKTTLTAAITKTLAAKGGANFLDYAAIDKAPEERARGITISTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGVQHIVVFVNKVDTIDDPEMLELVEMEMRELLNEYGFDGDNAPIIMGSALCALEGRQPEIGEQAIMKLLDAVDEYIPTPERDLNKPFLMPVEDIFSISGRGTVVTGRVERGNLKKGEELEIVGHNSTPLKTTVTGIEMFRKELDSAMAGDNAGVLLRGIRRDQLKRGMVLAKPGTVKAHTKILASLYILSKEEGGRHSGFGENYRPQMFIRTADVTVVMRFPKEVEDHSMQVMPGDNVEMECDLIHPTPLEVGQRFNIREGGRTVGTGLITRIIE
Protein: Endosomal/prevacuolar sodium/hydrogen exchanger (Endosomal/prevacuolar Na(+)/H(+) exchanger) (Vacuolar protein sorting-associated protein 44) (Q04121)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Endosomal/prevacuolar electroneutral Na(+)/H(+) exchanger which mediates intracellular sequestration of Na(+) cations, regulates vacuolar pH and contributes to osmotolerance following sudden exposure to hyperosmotic media. Contributes also to the postdiauxic/stationary phase resistance to osmotic stress and allows for the continued growth of cells until the acquired osmotolerance response can occur. Involved in hygromycin resistance probably through its influence on the electrochemical proton gradient affecting secondarily the entrance of hygromycin. Mediates pH-dependent vesicle trafficking out of the endosome. Contributes to K(+) sequestration and homeostasis.
Subcellular location: Endosome membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein.
Interaction partners:
- Na
- K
- Low affinity vacuolar monovalent cation/H
- Sodium/potassium exporting P-type ATPase 1
- High-affinity potassium transport protein
- Low-affinity potassium transport protein
- Outward-rectifier potassium channel TOK1 channel YORK)
- Putative uncharacterized protein YDR455C
Sequence:
MLSKVLLNIAFKVLLTTAKRAVDPDDDDELLPSPDLPGSDDPIAGDPDVDLNPVTEEMFSSWALFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGMVIGLIIRMSPGHYIQDTVTFNSSYFFNVLLPPIILNSGYELNQVNFFNNMLSILIFAIPGTFISAVVIGIILYIWTFLGLESIDISFADAMSVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHGQPATFSSVFEGAGLFLMTFSVSLLIGVLIGILVALLLKHTHIRRYPQIESCLILLIAYESYFFSNGCHMSGIVSLLFCGITLKHYAYYNMSRRSQITIKYIFQLLARLSENFIFIYLGLELFTEVELVYKPLLIIVAAISICVARWCAVFPLSQFVNWIYRVKTIRSMSGITGENISVPDEIPYNYQMMTFWAGLRGAVGVALALGIQGEYKFTLLATVLVVVVLTVIIFGGTTAGMLEVLNIKTGCISEEDTSDDEFDIEAPRAINLLNGSSIQTDLGPYSDNNSPDISIDQFAVSSNKNLPNNISTTGGNTFGGLNETENTSPNPARSSMDKRNLRDKLGTIFNSDSQWFQNFDEQVLKPVFLDNVSPSLQDSATQSPADFSSQNH
Protein: Matrix protein 1 (M1) (F0TTD6)
Organism: Influenza A virus (A/Puerto Rico/8-9NMC3/1934(H1N1))
Subcellular location: Virion membrane {ECO:0000256|HAMAP-Rule:MF_04068, ECO:0000256|RuleBase:RU362105}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_04068, ECO:0000256|RuleBase:RU362105}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_04068, ECO:0000256|RuleBase:RU362105}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04068, ECO:0000256|RuleBase:RU362105}.
Interaction partners:
Sequence:
MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEVLMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYRKLKREITFHGAKEISLSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKNDLLENLQAYQKRMGVQMQRFK
Protein: Rac GTPase activating protein 1 (F8VZ66)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQKSALAFLNRGQPSSSNAGNKRLSTIDESG
Protein: Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form] (O70156)
Organism: Rattus norvegicus (Rat)
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Secreted {ECO:0000250}. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity). {ECO:0000250}.
Interaction partners:
- Heat shock 70 kDa protein 4
- Apolipoprotein B-100
- Platelet glycoprotein 4
- Lysosome membrane protein 2
- Scavenger receptor class B member 1
Sequence:
MAFDDKMKPVNGQPDQKSCGKKPKGLHLLSSTWWCPAAVTLAILCLVLSVTLIVQQTQLLQVSDLLKQYQANLTQQDHILEGQMSAQKKAENASQESKRELKEQIDTLTWKLNEKSKEQEKLLQQNQNLQEALQRAVNASEESKWELKEQIDILNWKLNGISKEQKELLQQNQNLQEALQKAEKYSEESQRELKEQIDTLSWKLNEKSKEQEELLQQNQNLQEALQRAANSSGPCPQDWIWHKENCYLFHGPFNWEKSRENCLSLDAQLLQISTTDDLNFVLQATSHSTSPFWMGLHRKNPNHPWLWENGSPLSFQFFRTRGVSLQMYSSGTCAYIQGGVVFAENCILTAFSICQKKANLLLTQ
Protein: Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) (Q4ZJM9)
Organism: Mus musculus (Mouse)
Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process.
Subcellular location: Secreted {ECO:0000269|PubMed:23449976}.
Interaction partners:
Sequence:
MVLLLLVAIPLLVHSSRGPTHYEMLGRCRMVCDPHASRGQGPDGAPASVPSLPPGAKGEVGRRGKAGLRGPPGPPGPRGPPGEPGRPGPPGPPGPGPGGAAPPAGYVPRIAFYAGLRRPHEGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRGGDGTSMWADLMKNGQVRASAIAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHGGNTNKYSTFSGFIIYPD
Protein: Fhla protein (Four and a half LIM domains 1a) (Four and a half LIM domains a) (Four and a half LIM domains protein 1a) (Q6GQL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Recombination signal-binding protein for immunoglobulin kappa J region b
- Recombination signal-binding protein for immunoglobulin kappa J region a.
Sequence:
MSYYRHSGPRSYLSSTMTERFDCFYCRDNLQGKKYVKKDDKPVCVRCFDKLCANTCAECRKPIGADAKELNHKNRHWHEGCFRCAKCYKPLANEPFQAKDDGKIMCGKCGDRDGSPRCQGCYKVITPGCKNVEYKHKVWHEECFTCFECKQPIRTQSFLTKGDDMYCTPCHEKKFAKHCVRCKEAITSGGLTYQDQPWHSECFVCHTCKKPLAGARFTAHEDQFYCVDCYKSDVAKKCSGCQNPITGFGRGTNVVNYEDKSWHEYCFNCKKCSLSMAHKRFVINGEDIYCSDCAKKL
Protein: Myosin-4 (SWI5-dependent HO expression protein 1) (P32492)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruited to specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease, via its interaction with SHE3.
Subcellular location: Bud {ECO:0000269|PubMed:12499354}. Note=Accumulates preferentially in growing buds.
Interaction partners:
- SWI5-dependent HO expression protein 2
- SWI5-dependent HO expression protein 3
- Myosin light chain 1
- Actin
- Transcriptional regulatory protein ASH1
- Calmodulin
- Heterogeneous nuclear rnp K-like protein 2
- Myosin-2
- Increased sodium tolerance protein 2
- Myosin-1
Sequence:
MSFEVGTKCWYPHKEQGWIGGEVTKNDFFEGTFHLELKLEDGETVSIETNSFENDDDHPTLPVLRNPPILESTDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKRKDELEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVEMSQIESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETERNYHIFYQILEGLPEPVKQELHLSSPKDYHYTNQGGQPNIAGIDEAREYKITTDALSLVGINHETQLGIFKILAGLLHIGNIEMKMTRNDASLSSEEQNLQIACELLGIDPFNFAKWIVKKQIVTRSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQDHVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIENKLGILSLLDEESRLPSGSDESWASKLYSAFNKPPSNEVFSKPRFGQTKFIVSHYAVDVEYEVEGFIEKNRDSVSLGHLDVFKATTNPIFKQILDNRELRSDDAPEEQNTEKKIMIPARLSQKKPTLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFPSRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEAIVNFCQSILDATISDSAKYQIGNTKIFFKAGMLAFLEKLRTNKMNEICIIIQKKIRARYYRLQYLQTMESIKKCQSQIRSLLVRTRVDHELKTRAAILLQTNIRALWKREYYRAAIGQIIKLQCTCKRKLILDSVNRKFMLMAAVIIQSYIRSYGHKTDYRTLKRSSILVQSAMRMQLARRRYIVLQKEVEERNIRASYGIGLLEEAIEFKNSFILNLEMLNDSYTRLTQLLQGDLSNIPSKQRQEYETIVNGYNDKISKLKTLQVEIMNTLNKKNALKERKKKQSSLIQSHMQSLAAIKGNKPSRLSDEVKSMKQELAFIENVIAQDFTTTYSANKNDKVKGLGIAGQQVKPKLVNVIRRESGNPDLLELLMDLNCYTLEVTEGYLKKVNVTEVNGDNVLGPIHVITTVVSSLVRNGLLIQSSKFISKVLLTVESIVMSLPKDETMLGGIFWLSNLSRLPAFAANQKTLYEANGGDEKDKLTLIYLNDLENETLKVFDKIYSTWLVKFMKHASAHIEIFDMVLNEKLFKNSGDEKFAKLFTFLNEFDAVLCKFQVVDSMHTKIFNDTLKYLNVMLFNDLITKCPALNWKYGYEVDRNIERLVSWFEPRIEDVRPNLIQIIQAVKILQLKISNLNEFKLLFDFWYALNPAQIQAILLKYKPANKGEAGVPNEILNYLANVIKRENLSLPGKMEIMLSAQFDSAKNHLRYDTSAITQNSNTEGLATVSKIIKLDRK
Protein: Protein germ cell-less (Q01820)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the specification of pole cells and germ cell formation. Mothers with reduced glc function give rise to sterile adult progeny that lack germ cells.
Subcellular location: Cytoplasm. Note=Pole plasm.
Interaction partners:
- Cullin 3, isoform F
- Protein roadkill
- Maternal effect protein oskar
- RING-box protein 1A
- RING-box protein 1B
- Succinate--CoA ligase subunit beta, mitochondrial
- Kelch-like protein diablo
- AT19737p
Sequence:
MGQIVGSMHMNVAEVFSNRRKRKRSTDSSLGKDDPAQLDTTQPKKKKLLTTTQYIYKALFKEEKNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSDEIEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYSKQPNLLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQRAEALKTQELLVNAGVETHAPSGDVVQWTYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNHYMDLKIIYNDNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEPGYQKWRWTGFNFGMDLILIMDSRRLNIRRHHRHEHERVLSLQTKRKFMVRTTVTSINAQRQAVFTQTSEICSLSLEKNEEVPLMVLDPKLVHPLLISINMLVVMPPNQSFKEIVPLSEEATTSLSIPISEIGANSDRPLSPSSADDSAVFIGDSEPSTPSSPAPRPRIAWSASETGAICGQLAC
Protein: Probable membrane-associated kinase regulator 1 (Q3E936)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May negatively regulate brassinosteroid signaling.
Subcellular location: Cell membrane {ECO:0000250}.
Interaction partners:
- Probable membrane-associated kinase regulator 6
- Membrane-associated kinase regulator 5
- Probable membrane-associated kinase regulator 2
- Probable ADP-ribosylation factor GTPase-activating protein AGD15
- Protein BRASSINOSTEROID INSENSITIVE 1
Sequence:
MRRQPPRPRNSPPQSHSSPSSSSSEFEFNISISPRKASSSLCPADELFYKGQLLPLQLSPRLSLVRTLGSSTSSSDYTSSSSSSVATSAARDSTESNSSTDSTASFPLLHPPPLDCCDSSRPSSVTDDEDFFFKPPKNKSSSGGFSLSRFSSVFKKDPKTNLHHHSSSSSTATTAAAPSSVKRMSSTAKEVIRKYMKKVKPLYEKLSPKQSSNIKTESSSSLKDSGNNIRGTTTVTTVTAAPTVVSSGGGLSISFSGNLMKYTKRGRCAASCPSSMRSSPNHSGVLTRGGFPVHQGSCSSSSSNNNSVSSSMEELQSAIQGAIAHCKNSMLQKNLVSSLEI
Protein: Profilin-1 (AtPROF1) (AthPRF1) (allergen Ara t 8) (Q42449)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to actin monomers and regulates the organization of the actin cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate. Binds ACT1, ACT7 and ACT11 and inhibits actin polymerization. Coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during axial cell expansion. Binds G-actin and poly-L-proline in vitro. Inhibits cell growth of various pathogenic fungal strains. May play a role as antifungal proteins in the defense system against fungal pathogen attacks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:17933902, ECO:0000269|PubMed:19200149}. Note=Probably associated with cytoplasmic actin filaments. {ECO:0000269|PubMed:19200149}.
Interaction partners:
- Actin-depolymerizing factor 1
- Actin-depolymerizing factor 7
- Actin-depolymerizing factor 10
- Actin-depolymerizing factor 4
- Actin-depolymerizing factor 3
- Actin-depolymerizing factor 2
- Formin-like protein 2
- Formin-like protein 1
- Actin-depolymerizing factor 9
- Actin-depolymerizing factor 8
Sequence:
MSWQSYVDDHLMCDVEGNHLTAAAILGQDGSVWAQSAKFPQLKPQEIDGIKKDFEEPGFLAPTGLFLGGEKYMVIQGEQGAVIRGKKGPGGVTIKKTNQALVFGFYDEPMTGGQCNLVVERLGDYLIESEL
Protein: Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) (Q8CF60)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (By similarity). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (By similarity). Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:26089202}.
Interaction partners:
Sequence:
MTMAAGPSSQEPEGLLIVKLEEDCAWSHEVPPPEPEPSPEASHLRFRRFRFQDAPGPREALSRLQELCRGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELRPESGEEAVTLVERMQKELGKLRQQVTNQGRGAEVLLEEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPQRDSQAVKERALSAPWLSLFPPEGNVEDKDMTGTQLPESLEDMAMYISQEWDHQDPSKRALSRYMVQDSYENSGTLESSIPSQEVSSTHVEQGEKLWDSSVQTCKEGMNPRNPVPGVEKFENQERNVESVSPESTHPPVLLPGQARREVPWSPEQGRLDDREGHWECPPEDKIEESLVGTPSCKGLVQAKEQPKKLHLCALCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHIGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPFQCNACGKSFSCNSNLNRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEKERLDPFPECGQGMNDSAPFLTNHRVEKKLFECSTCGKSFRQGMHLTRHQRTHTGEKPYKCILCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLTSHQRTHTG
Protein: Ig-like domain-containing protein (Q31206)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSWVLRAAVVCALLLQLDARPSWTRIPLGSHSLRYFYTAVSRPGLGEPWFIIVGYVDDMQVLRFSSKEETPRMAPWLEQEEADDWEQQTHIVTIQGQLSERNLMTLVHFYNKSMDDSHTLQWLQDCDVEPDRHLCLWYNQLAYDSEDLPTLSENPSSCTVGNSTVPQISQHLEGHCSDVLQKYLEKGKERLLRSDPPKAHVTRHPRPEGDVTLRCWALGFYPADITLTWQKDGEELTQDVEFVETRPAGDGTFQKWAAVVVPLGKVQSYTCHVDHEGLPEPLTLRWEPAWYQKPWIWIVATVFSILLICLCVARRPMKKNAGGRGRRDTQEAGRDSPQDSSKTVVDDEEMGVCFWKIKSCKTCLGHSPGTSGSSGRCPFEWLGCEDSRPVLATLDRNTSHLSGSRI
Protein: N-terminal acetyltransferase B complex catalytic subunit NAT3 (NatB complex subunit NAT3) (EC 2.3.1.254) (NatB Nalpha terminal acetyltransferase 3) (Q06504)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, it is presumed to N-acetylate 15% of all yeast proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- N-terminal acetyltransferase A complex subunit NAT1
- N-alpha-acetyltransferase 30
- N-terminal acetyltransferase B complex subunit MDM20
- N-alpha-acetyltransferase NAT5
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- N-terminal acetyltransferase A complex catalytic subunit ARD1
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
- N-alpha-acetyltransferase 40
- ATP-dependent RNA helicase DBP7
Sequence:
MTTIQPFEPVDLFKTNNVNLDILTENFPLEFYFEYMIIWPDLFFKSSEMTVDPTFKHNISGYMMAKTEGKTTEWHTHITAVTVAPRFRRISLASKLCNTLETMTDVMPHEVNFIDLFVKCNNQLAIKLYEKLGYSVYRRVVGYYNSAEDGYPDTLKKVDDNKDAFDMRKAMARDRNRSVRPDGRSHKCYPHDVRF