wanglab/gogpt-training-data huggingface dataset:
Protein: Import motor subunit, mitochondrial (EC 3.6.4.10) (Endonuclease SceI 75 kDa subunit) (Endo.SceI 75 kDa subunit) (Heat shock protein SSC1, mitochondrial) (mtHSP70) (P0CS91)
Organism: Saccharomyces cerevisiae (Baker's yeast)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of the processed frataxin homolog YFH1 into the mitochondrion (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P0CS90}.
Interaction partners:
Sequence:
MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINMKFSRAQFETLTAPLVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSRMPKVVETVKSLFGKDPSKAVNPDEAVAIGAAVQGAVLSGEVTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAAGQTSVEIRVFQGERELVRDNKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKDSSITVAGSSGLSENEIEQMVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKEFEGKVDKAEAQKVRDQITSLKELVARVQGGEEVNAEELKTKTEELQTSSMKLFEQLYKNDSNNNNNNNNGNNAESDETKQ
Protein: DNA-binding protein (O92611)
Organism: Suid herpesvirus 1 (SuHV-1) (Pseudorabies virus)
Interaction partners:
Sequence:
MEAAAKTVTVRAAPLGYVYVTPIEALRRDLLALLVARSADDAAAVAPLVRGLTVEAGFAGHVAVVAGARTTGLGGGLTLKLTPNHFHPNVFFFHNGDCVPPSSAAPALSRACEAARARFGFSAYRTPVDNAEETTGAEVCARLGLAADAHAAYLVVADGFKEAVYLCNAFLHYGGAGTVSINGHEAWRVPLYPVHLFMPDVNRLVADPFNAKNRSISEEFVYPRPFFNGPLCRLLHGYVLGPAAVATRVRNLDAVARGAAHLAFDENHESAVLPADVTFTLFEQRRRGGDAAAGGLERRMASVMSADAALSLEALVAAGVYDEEPPALDDWPVLSEAGAKDGGAAAASAGAPVSQAAALGAYVSRAAGLVGALVFSSNSVLYLTEVDDAGAADARKEGAGPSFNRFYQVAAPYLAGNPQTDKDGRVLLHTASQPATAPGNHDFAMDHLVMACGFCPQLLARVLFYLERCDAGTFVGRGDVDAVRYVAGSLDAEVPCSLCDRASRPACAHTTLHRLRHRSRASARRRSPMGVFGTMNSAYSDCDVLGNYASYGALKRPNDSEPPKAIMQDTYRAAVDRLLADVAGARIGETVTDHAGFRHALRALRDTVEQAADRFVRTLVETRDFKLRDALYDANHTMSLSLDPYSGALCPATSFLARRTLLAVLQDLALSQCHGVLHGQPVEGRNFRNQFQPVLRRRVVDMLNGGFVTAKTVTVTLADGIVAPDPTKGSAEPPARDHDGDLARVSFEVLRELRVKSRVMFSTGSGSLSDAARARVAGLAGAYQRPDTAVDVLNGPLGFLLKQHHATLFPRGKPPGGQSPNPQWFWTLLQRNQLPARLLTKDDIETIAAVKRFSVDYGAINYVNLTPGTVAELAQFYLANLILRYCDHKQFFINSLTGITMQSKRPRDPAAVMAWVRRPLADAADAERAAREVLDAPRDDTWVATYTSSHLLRSVMASRPLVVLGLGVSKYHGMAGNNRVFQAGNWSGLNGGKHVCPLMVFDRTRHFVLACPRVGFTCSQTGGGAGLHDHSLGEHVKTILADGGPLVQTAVYAAVLHALGARTQHLEPDDWRAIVDDEFLAAALAEINGRVADRDGRWSVEAAAELVRDLEGQTGADGGGEETAFDFGACGAGGDAGAGLAPASLAPAELGGKRPPPEDDLFDMGAPPEKRLTFDML
Protein: Orf16 protein (Q38002)
Organism: Streptococcus phage Cp-1 (Bacteriophage Cp-1)
Interaction partners:
Sequence:
MPLETRFSTSTTANVENFGTGVAPWTEAYANAWQFSGDTDYGYMTNGNTTYIQYGQNDPSVWASMRFWGESVEILEETKNDDNSITAKIRVKALFWWSKRVSSNAGYRVEYDIKINGRTVWTFSGYTTDEVIKNDEVAQDFTVTIPAEESSSASALNINVSYPDGQYSDNSFYVGVYLYNTNKKKPKTLKPWAIRKSGIFKTLNRPSGIFQQRKSSWQDISEQPANAVGQAVTAPHSVRKSGQWIGQGQIGQE
Protein: Sulfhydryl oxidase (EC 1.8.3.2) (Q585M6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Endoplasmic reticulum oxidoreductin, putative
- UDP-glucose:glycoprotein glucosyltransferase, putative
Sequence:
MFSRSFVVFAGLLCCCLSKSVAQVATGSPRPGLFHLDSSVVDLSGDDFSRVHRVAPLCPWIVLFYNDGCGACRRYASTFSKFAGGLKVEHGKDALQIATAAAVNCASEVDLCRKYDINFVPRLFFFYPRDSCRSNEECGTSSLEHVAFENSHLEVDELESEVRRLVNKHMVVDDSLKERCIDMHFKLYTSKEELVKRSVSSTDESGRFVETTELYATDIAGAFFSAMHYDVSLVGTEPRERLTALEDFVLLVKDSLPSIGADGVVSALESITAERPFTVASWQDAVVKSGIPFDGSPRNVRWRTCRGSSPQYRGFPCGMWLLLHALTVNTPADRNVLEVIQNYIRYFFSCKECRDHFIQFNFSPNEDPVLQLWRAHNNVNARLANVKDGADPLVPKRQFPTLEACTECYDGAGNFIEAHVTGFLKQRYLWDPKAVGLMESNDDLNEVDPASKDANVGRNVESSGKGKGDGGARGNSKEVRSDHAGGKGKGYSVLLFSNVFIILLFVCLGSFDYMKRLRVRKRRDRY
Protein: Sulfate transporter 3.1 (AST12) (AtST1) (Q9SV13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: H(+)/sulfate cotransporter that may play a role in the regulation of sulfate assimilation.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGTEDYTFPQGAEELHRRHHTVEAPQPQPFLKSLQYSVKETLFPDDPFRQFKNQNASRKFVLGLKYFLPIFEWAPRYNLKFFKSDLIAGITIASLAIPQGISYAKLANLPPILGLYSSFVPPLVYAVLGSSRDLAVGTVAVASLLTGAMLSKEVDAEKDPKLYLHLAFTATFFAGVLEASLGIFRLGFIVDFLSHATIVGFMGGAATVVSLQQLKGIFGLKHFTDSTDVISVMRSVFSQTHEWRWESGVLGCGFLFFLLSTRYFSIKKPKFFWVAAMAPLTSVILGSLLVYFTHAERHGVQVIGDLKKGLNPLSGSDLIFTSPYMSTAVKTGLITGIIALAEGVAVGRSFAMFKNYNIDGNKEMIAFGMMNIVGSFTSCYLTTGPFSRSAVNYNAGCKTAMSNIVMAIAVMFTLLFLTPLFHYTPLVVLSAIIISAMLGLIDYQAAIHLWKVDKFDFLVCMSAYVGVVFGSVEIGLVVAVAISIARLLLFVSRPKTAVKGNIPNSMIYRNTEQYPSSRTVPGILILEIDAPIYFANASYLRERIIRWIDEEEERVKQSGESSLQYIILDMSAVGNIDTSGISMMVEIKKVIDRRALKLVLSNPKGEVVKKLTRSKFIGDHLGKEWMFLTVGEAVEACSYMLHTFKTEPASKNEPWNNV
Protein: Inner membrane protein YiaA (P0ADJ8)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane protein YiaB
- O-acetyltransferase WecH
- Inner membrane protein YbcI
Sequence:
MDNKISTYSPAFSIVSWIALVGGIVTYLLGLWNAEMQLNEKGYYFAVLVLGLFSAASYQKTVRDKYEGIPTTSIYYMTCLTVFIISVALLMVGLWNATLLLSEKGFYGLAFFLSLFGAVAVQKNIRDAGINPPKETQVTQEEYSE
Protein: Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (P82611)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle.
Subcellular location: Mitochondrion.
Interaction partners:
- Citrate synthase
- Isocitrate dehydrogenase subunit 2, mitochondrial
- Isocitrate dehydrogenase
- Isocitrate dehydrogenase
- Isocitrate dehydrogenase subunit 1, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate lyase
- dihydrolipoyllysine-residue succinyltransferase
- Nuc2p
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
Sequence:
MLSASRTALRAPRSVRGLATASLTKDSQVNQNLLESHSFINYKKHLENVEIVKSRLNRPLTYAEKLLYGHLDDPHNQEIERGVSYLKLRPDRVACQDATAQMAILQFMSAGIPQVATPSTVHCDHLIQAQVGGPKDLARAIDLNKEVYDFLSTACAKYNLGFWKPGSGIIHQIVLENYAFPGALLIGTDSHTPNAGGLGQLAIGVGGADAVDVMSGLPWELKAPKIIGVKLTGKMSGWTSPKDIILKLAGITTVKGGTGSIVEYFGSGVDTFSCTGMGTICNMGAEIGATTSVFPFNDSMVDYLNATGRSEIAQFAQVYKKDFLSADEGAEYDQVIEIDLNTLEPHINGPFTPDLATPVSKMKETAIANGWPLEVKVGLIGSCTNSSYEDMTRAASIIKDAGAHGLKSKALYTVSPGSEQVRATIARDGQLKTFEDFGGVVMANACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPATHAFVASPEMATVYAISGDLGFNPITDTLVGADGKEFKLKEPQGVGLPPDGYDPGENTYQAPPEDRASVEVVISPTSDRLQKLSPFKPWDGKDAERLPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENGKANEVRNHYTGKYDGVPQTAAAYRDAGHKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINFDDEVDLIGLTTLAPGKDVILRVHPKEGEAWEAVLTHTFNSEQLEWFKHGSALNFIKSKY
Protein: Ubiquitin-conjugating enzyme 15 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 15) (PM42) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa 15) (Ubiquitin-protein ligase) (P42743)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
- Ubiquitin-activating enzyme E1 2
- Ubiquitin-ribosomal protein eL40y fusion protein
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Ubiquitin-activating enzyme E1 1
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-conjugating enzyme E2 32
- E3 ubiquitin-protein ligase BRE1-like 2
- Ubiquitin-conjugating enzyme E2 6
Sequence:
MTSSSAPSRKALSKIACNRLQKELSEWQLNPPTGFRHKVTDNLQKWTIDVTGAPGTLYANETYQLQVEFPEHYPMEAPQVVFVSPAPSHPHIYSNGHICLDILYDSWSPAMTVNSVCISILSMLSSSPAKQRPADNDRYVKNCKNGRSPKETRWWFHDDKV
Protein: DNA-directed RNA polymerase subunit alpha, putative (EC 2.7.7.6) (Q8IEN9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 40S ribosomal protein S3
- DNA-directed RNA polymerases I, II, and III subunit RPABC2, putative
- 40S ribosomal protein S19
- 40S ribosomal protein S18, putative
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S15A, putative
- 40S ribosomal protein S11
- 40S ribosomal protein S11, putative
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Ribosomal protein S16, mitochondrial, putative
Sequence:
MSLLFLLLFFLTECNIYWSFCVILKTKNPAFLPIQIKNPERHKPNNLKRFYINQNEGVKNRKYNNRDIYKFEGIDEENKDGKENIDEDYLKEYEEAYHKYDDMDDDERKRRGSENKMNWFEIRKGEKEREHRYNVYDNEIIKKDLKEIDLERVDKMNRSIGELPPYIYEGGKVYEGMPMDYKPEIYDFHKYNKYFDDLCKEKKSLIDSYQLDKKLLDDTYYDAKRGGPKTFGFRFKQIQPVKYHEGRAYTYFFMHSHDVELSPIFLNAFRRVAIKHLKGGRVTALRIPNMKHEFYCIVGVRENFFDLAQNLRQITFKNVPEDVDMDNYMIGKFRIKGPMIVVAGHMQLPKNVEIVNRNQYICSVAAGSYLSMDVKIESIEEYVMPEYGSQSRNRDICKDNFIHFSSSCTPVEHFVFTGQRRGINLDTLGEINIVEMHTDGSITPKSALLKTIDYISENFQYIENALYNNCHICDDGSLDEEFRNPEFYMDKDRYTDVPWNKYKTTSEELEETKNWLYRKDVHRQYNIDPESEQSKEERNLMWEKSKKMREEIQKRKEQIKKGPSASEGEMVPDEERHDCLLDWPVDKSERNMNPPRWVIERPLEKNPHVGHEEIYDEGI
Protein: RE11167p (Q9VKD8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Precursor RNA processing 3, isoform A
- U4/U6 small nuclear ribonucleoprotein Prp31
- Pre-mRNA-processing factor 6
- 116 kDa U5 small nuclear ribonucleoprotein component
- BcDNA.LD23634
- Microfibrillar-associated protein 1
- LD44732p
- Thioredoxin-like protein
- SD09427p
- Pre-mRNA-processing-splicing factor 8
Sequence:
MGSSSSGKKHKKDKKNRHRSRSSERPRRVTEDEDVTLDLTDDSSSRHRHHKHKKHKEHRHKHHKQKERERANEVISLEESDSDSSDCVEVPVQAQVQAQAKLRDARESSNRDKERDSGRDRELLRERERERDRERERDRDREKEREREREKERLREREEREREREKERIREREKERLRERERERERERVRELTAPPPPQISKHAEYESRREREIERERDARKRSGRERERERNRERSRSQSPASSSRKPATKEREPSSRSFSPIPENGAGDVLSITETNKLRAKLGLKPLEVDSGPSKAGPPPGSSSQGEIKKPHGEADLSSYKDEWGEFLHKPADNLKEKREAEKLREKLKQRKEKRFLEERLARIKTLGESDEETDNVSKWVDKNKRVVNEREEAMRKAKELEELDEAFGVSEILEQEKTKARQRAYGDSNLKGLRVDHDMDDFGEGRTVILTLKDQDVLNEEEGDTLVNVNMVDEERYKKNVANKKQNPLSYGYNVYEEQYDELGNPIERSVLEKYDDEMEGQPKKRKNFVIGENMDEEREHRRKLLEIKTKLAGKRLETLEDTNLQLASDTYSAEELAKFKKPKKKVKKLRQKLKAEDLAPLAMGEASGSSDFGSRGGRYRDHEDAEMEEFKPQIKVEVEDDDLERVLAKARKLKQKENIIKKPLPVDFESIQREIKPEHVEDTASGVVLTGVDGNIVLNATAEFCRTLGDIPTYGMAGNRNEDSNDMMDFDKTEQPEEHMETHTDEPALSHGTWNSVNPDEVMQPADLDNLGEDLEDRAILDEEPDVGAGVANALRLALSKGYLEKEEKNRPSNTKMAHLQAKNYSIEDKAAGEDEKVGRRDRFHFGPITDFKDKETFKPNVKLDYIDDNGRILNLKEAFRYLSHKFHGKGPGKNKIEKRLKKMEQDGLMKTMSSTDTPLGTLTMLQQKQKETKTAYVVLSGNNKNVPGVSGSAIAKFK
Protein: Protein c-Fos (Cellular oncogene fos) (H0ZPP9)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Interaction partners:
- Transcription factor Jun
- Transcription factor JunB
- Mitogen-activated protein kinase.
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase
- mitogen-activated protein kinase
- mitogen-activated protein kinase
- mitogen-activated protein kinase
- mitogen-activated protein kinase
- Early growth response protein 1
Sequence:
MMYQGFAGEYEAPSSRCSSASPAGDSLTYYPSPADSFSSMGSPVNPQDFCTDLAASSANFVPTVTAISTSPDLQWLVQPTLISSVAPSQSRGHPYGVSAAAPTTYSRPAVLKAPGGRGQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEEEKSALQAEIANLLKEKEKLEFILAAHRPACKMPEELCFSEELAAASAATALDLGTPSPPMTEEAAFALPLMPEAPPAVPPKETSSSGLELKAEPFDELLFSTGPREASRSVPDMDLPGASSFYPSDWESLTAGTSDLLLIRLFFGAASGSLSGQRQAGDPVRC
Protein: Fructose-bisphosphate aldolase 4, cytosolic (AtFBA4) (EC 4.1.2.13) (Cytosolic aldolase 3) (cAld3) (F4KGQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fructose-bisphosphate aldolase that plays a key role in glycolysis and gluconeogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22561114}.
Interaction partners:
- Triosephosphate isomerase, cytosolic
- Triosephosphate isomerase, chloroplastic
- Sedoheptulose-1,7-bisphosphatase, chloroplastic
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- Phosphoglycerate kinase 2, chloroplastic
- Aldolase-type TIM barrel family protein
- transaldolase
- Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
Sequence:
MSCFKSKFAGKSYFRRTFHSSIIQFHPQLSILIWHRRYSIIRTYELIANAAYIGTPGKGILAADESTGTIGKRFVSINVENVESNRRALRELLFTTPGALQYISGIILFEETLYQKTASGKLFVDVMKEAGVLPGIKVDKGTVELAGTNGETTTTGLDGLGDRCKKYYEAGARFAKWRAVLKIGNNEPSELAIHENAYGLARYAVICQENGLVPIVEPEILVDGSHDIEKCAYVTERVLAACYKALSDHHVILEGTLLKPNMVTPGSDSGSKVKPEVIAKHTVRALQRTVPAAVPAVVFLSGGQSEEEATVNLNAINQLKGKKPWSLTFSYGRALQQSTLKAWGGKEENVDKAQKAFLARAKANSEATLGGYKGDAQLGEGASESLHVKDYKY
Protein: Serine protease inhibitor (Serpin-2) (Q9U1I7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKHLCLLLLATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARSKTAQEMRNVLKLPDDKKEVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIVGFKPKLSKMDVTLRLPKFKIEFFAQLNKILVAMGIQDAFEKSADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRLSVPMPSSQMVFNADHPFAYVIRDRETIYFQGHFVKPNE
Protein: Establishment of sister chromatid cohesion N-acetyltransferase 2 (H0YB88)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKAFRVLSEPIGPESPSSTECP
Protein: Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Q61704)
Organism: Mus musculus (Mouse)
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Subcellular location: Secreted.
Interaction partners:
- Protein AMBP
- Vitronectin
- Beta-2-glycoprotein 1
Sequence:
MRTMWWPCLVLALLSGLETSGFPRSPLQLLGKRSLPEGVVDGIEVYSTKISCKVTSRFAHNVVTTRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAQKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRNKGKYEMYLKVQPKQLVRHFEIDAHIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTIVYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNIVFVIDVSGSMSGRKIQQTREALLKILDDVKEDDYLNFILFSTDVTTWKDHLVQATPANLKEAKTFVKNIHDQSMTNINDGLLKGIEMLNKAREDHTVPERSTSIIIMLTDGDANTGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLETLALENHGLARRIYEDSDANLQLQGFYEEVANPLLTNVEVEYPENAILDLTRNSYPHFYDGSEIVVAGRLVDRNMDNFKADVKGHGALNDLTFTEEVDMEEMDAALKEQGYIFGDYIERLWAYLTIEQLLEKRKNAKGDEKENITAEALDLSLKYHFVTPLTSMVVTKPEDNEDQTSIADKPGEEAIAETTTMSFLTTQQSSQSPYYYVDGDPHFIIQIPGKNDSICFNIDEKPGTVLRLIQDPVTGITVTGQIIGDKRSNASSRTGKTYFGKLGITNAWMDFRVEVTTEKIILGTGAELSTFSWLDTITVTQTGLSVTINRKKNMVVSFGDGISFVIILHQVWKKHPVHQDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVFGIRPGSDPTKPDATMVVKNHRLTVTRGSQKDYRKDASVGTKVICWFVHNNGEGLIDGVHTDYIVPSLF
Protein: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (A5JNM0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
LFRDGLLPEQTHFVGFARSDLTVDASNTACMPYMKVADSEAERLSVFFTVTSYVSGKYADESAFSNLHTHLLSLPGGGKANRLFYLALPPSVYHDVTKNIKHHGMSTKGWSRVIVEKPFGRDLQSSEELSTHLSSLFTEDQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSIACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIAPITMSDVVLGQYVGDPEGEGDAKLGYLDDPTVPKGSTQATFTTAVLYVHNERWDGVPFILRCGKALNERKAEVRLQFTEVPGDIFGAQCRRNELVVRVQPNEAVYAKMMSKKPGVYFHPEETELDLTYKSRYKDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIENEKIPPTPYKYGSRGPTEADELSKRVGFRYEGTYKWVNPHRL
Protein: Prostate and testis expressed 6 (Q9CQB8)
Organism: Mus musculus (Mouse)
Interaction partners:
- Prostate and testis expressed 10
- Prostate and testis expressed protein 3
- Prostate and testis expressed protein 4
- Prostate and testis expressed 5
Sequence:
MKNFLRLCLFLLCFETGFPLQCVQCQSYKNGECATKKETCTTKPGETCMIRRTWYANEIHNLQDAETKCTNSCKFEEKTSGYLTTHTYCCSHGDFCNDINLPIVMT
Protein: E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B) (Q96G75)
Organism: Homo sapiens (Human)
Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25793641}.
Interaction partners:
- Armadillo repeat-containing protein 8
- WD repeat-containing protein 26
- Glucose-induced degradation protein 8 homolog
- E3 ubiquitin-protein transferase RMND5A
- E3 ubiquitin-protein transferase MAEA
- Ran-binding protein 10
- Glucose-induced degradation protein 4 homolog
- Protein yippee-like 5
- Ran-binding protein 9
- Muskelin
Sequence:
MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLVMSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRIIF
Protein: Retinoic acid receptor, gamma (D3ZF61)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MATNKERLFAPNALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGPPDNYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGSQGKRGQSPQPDQGP
Protein: Lysine-specific demethylase ELF6 (EC 1.14.11.-) (Early flowering 6) (Jumonji domain-containing protein 11) (AtJMJ11) (Protein JUMONJI 11) (Lysine-specific histone demethylase ELF6) ([histone H3]-trimethyl-L-lysine(27) monodemethylase JMJ11) (Q6BDA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3, thus acting as a positive regulator of gene expression. Demethylates tri-methylated (H3K27me3) and di-methylated (H3K27me2) H3K27me. Inactive on H3K27me1, H3K4me3, H3K9me2 and H3K36me3. Acts as a repressor of the photoperiodic flowering pathway and of FT. May also be active on H3K4me. Binds around the transcription start site of the FT locus. Required for epigenetic reprogramming by resetting the expression of the floral repressor FLC locus, thus aluviating cold-mediated FLC epigenetically silencing occurring during vernalization and preventing inapropriate epigenetic states inheritence.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Histone-lysine N-methyltransferase CLF
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Histone-lysine N-methyltransferase EZA1
- Histone H3-like 5
- Histone H3.1
- Histone H3-like 2
- Histone H3.3
- Histone H3-like 3
- Histone H3-like centromeric protein CENH3
- Histone H3-like 1
Sequence:
MGNVEIPNWLKALPLAPVFRPTDTEFADPIAYISKIEKEASAFGICKIIPPLPKPSKKYVFYNLNKSLLKCPELVSDVDISKVCKEDRAVFTTRQQELGQTVKKNKGEKGKSNSQRSGVKQVWQSGGVYTLDQFEAKSKAFYKTQLGTVKELAPVVIEALFWKAALEKPIYIEYANDVPGSAFGEPEDHFRHFRQRKRRGRGFYQRKTENNDPSGKNGEKSSPEVEKAPLASTSLSSQDSSKQKNMDIVDEMEGTAGWKLSNSSWNLQMIARSPGSVTRFMPDDIPGVTSPMVYIGMLFSWFAWHVEDHELHSMNYLHTGSPKTWYAVPCDYALDFEEVIRKNSYGRNIDQLAALTQLGEKTTLVSPEMIVASGIPCCRLVQNPGEFVVTFPRSYHVGFSHGFNCGEAANFGTPQWLNVAKEAAVRRAAMNYLPMLSHQQLLYLLTMSFVSRVPRSLLPGGRSSRLRDRQREEREFLVKRAFVEDILNENKNLSVLLREPGSRLVMWDPDLLPRHSALALAAAGVAGASAVSPPAVAKKELEEGHSELQNKEKTSLLEELSLFMEKLNDVYYDDDDGLLNDFQVDTGTLPCVACGVLGFPFMSVVQPSEKALKDLSERQGETDAQEIMTLSSEKSDCEWKTSSRYIRPRIFCLEHTIELQRLLQSRGGLKFLVICHKDFQKFKAHAAIVAEEVKVPFSYDDVLLESASQEELSLIDLAIEDEEKYEHSVDWTSELGINLRYCVKVRKNSPTKKIQHALSLGGLFSDTSQMLDFTTIRWLQRKSRSKAKPSSTSSFTPCEHLEVKADGKLRDNLDSQTGKKEEKIIQYSRKKKLNPKPSAEQVQELATLAKSKDFDKTCKNFSSRSHLDSAIRSEMNSEIGDSGRVIGVSFSINPCSSSFTVGHGQEHPEITVKFGSDLDGNVTNSLSMVNGDSADLTLTSISREQHQGHSMTSNNNGSNSGSHVVASQTILVSTGDNHDGPRKLSGDYVCSDVSVRGIQEAVEMSDQEFGEPRSTVTNIEDEQQSQIVKPTQREAVFGDHEQVEGAEAVSTRENLCSEIILHTEHSSAHVGMEIPDINTASENLVVDMTHDGEPLESSDILSSSNGDEASSNGLQVLNDELSMESEVSSSENTEVIEAPNSMGEAKKKRKIESESETNDNPESSIGFIRSPCEGLRSRGKRKATCETSLKHTETSDEEKKPIAKRLKKTPKACSGSRQQEVPTTTHPNRCYLEGCKMTFESKAKLQTHKRNRCTHEGCGKKFRAHKYLVLHQRVHKDERPFECSWKGCSMTFKWQWARTEHLRLHTGERPYICKVDGCGLSFRFVSDYSRHRRKTMHYVT
Protein: CCAAT/enhancer-binding protein alpha (C/EBP alpha) (P49715)
Organism: Homo sapiens (Human)
Function: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11242107}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleolus {ECO:0000269|PubMed:20075868}.
Interaction partners:
- Runt-related transcription factor 1
- Cyclin-dependent kinase 2
- Peroxisome proliferator-activated receptor gamma
- Cyclin-dependent kinase 4
- Transcription factor PU.1
- CCAAT/enhancer-binding protein beta
- Receptor-type tyrosine-protein kinase FLT3
- Forkhead box protein O1
- Protein CBFA2T1
- Cyclin-dependent kinase inhibitor 1
Sequence:
MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVMPGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGAAHPDLRASGGSGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA