wanglab/gogpt-training-data huggingface dataset:
Protein: Glycosyltransferase (Q54GL6)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- UDP-glucose 4-epimerase
- 1,4-alpha-glucan-branching enzyme
Sequence:
MTLISIIKKNLIGVIIILAIGLHITLIYKYSTFSFINNKNNRNNLPPQHQQPSNIQHNIQHDIHQKPHYSNKQSQKTQQQNESPLEGQKFIYSKQKEKILKYIDYKQFGLFNGGGGVIVNSKPSNTNDNGGIYKDLNLNELDEISSWSPNTIVDFNKRHGDDSLPSICSEIDFQEIKTCEGSNYYRAMVTPTPVLDENSMNYTLKPNSQYRAKFNYYPREFSKQPLITILTAFYNIEPDIFEESAATVFGQSLQNFEWVIVNDCSPNQTLVDLSLGKYRELAKIDPRIVIIDLKKNVRLPGARNAGVKVARGKYIVSLDPDDMFENTYLEKAVWFLETHKEYTLCNAWTVGFANKSYVWKNGYHNGDRNLKENQITVASVMRTQALRDVGGFDSKLIHGMEDWDLWIRMADNGHWGHTLEEFHFWYRVSPPGKWDAIDNLAKFNAFLENQQVKYKNAYGKGVPKLSRPPQEKMEAVDDLIPFENNLKKCRPRVLLLIPYMEVGGADQFNYNFAQGMVLDGWEVSIATTKTSDNKWFPQFARVTPDIFIMPRFSKNTDQCRFLAYYIKSRQFDVVYVSNSEQAYHYLSYLRANAPGPAYIDYTHSETPKWKDGGYARYSFGSEKLLDRSIFASEHLRQYCIRRGHNANKTATVLIGIDSDKYVPKPENRAIIRKELGFPDNVLVIVFVARLESEKQPEVFAEVLRRVDEMGYDFRAISIGGGLLFNDLNETISKSGLSEKVRLLGNIPNSQVSKYVSGSDVFFLPSKVEGISLAIYEAMSQQVCAVSAKVGGQAELVTPDVGFLVVPGTPTEVDEYTEIIADLASNLTLASELGKKSLEKILNGFSVKDTLHRMKEEFCNSAIVTRYTTPMFTNKLFSKLSNEQAVLGHEYERAIDELLPMWNQLTSLTKQLAPPPTLTEKEIKRKPSPYPLHKPEEVLDSINITGLRVVENIMIEKKKVDRKMKIILKDFQEQFIRRNPKFADKQLVPNEFLHQYNHGVDNWDDELPYPYQQQEYVAYIPNAFVGTGESATIFDWDRVFLLNYSPTQQETFTMPLEESRICHVEKTKKMVTLLQKQFSFENFIIDQLPKLSLVLEELELDPEIKILVPFTDFAKTIMVDTLKFSPDRIIYFKPGSGWDPCVVFFANTLLLPTPIPPGQPPREMISKLRDYFYQKNDIDIVAPINRNVIMYASRKSTLSPLRKVSNEQKVIETIKNILQSQGEGKYEFIEWDGLETITPELVQLSSRVKILIGMTGANLLPMVVCQPNTIVVEFMHENPWLSFWSTSESLQHENWMIPIKATSHDSLEIQVPIDQLTNTLNQIFNPQQQQQQSSSSNSK
Protein: Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) (P38319)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Cleaves also 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II. Contributes to DNA repair after radiation damage. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12206772}.
Interaction partners:
- DNA topoisomerase 1
- DNA-
- Apurinic-apyrimidinic endonuclease 1
- Aprataxin-like protein
- DNA-dependent metalloprotease WSS1
- Polynucleotide 3'-phosphatase
- DNA topoisomerase 2
- DNA repair protein RAD1
- DNA ligase 4
- Crossover junction endonuclease MUS81
Sequence:
MSRETNFNGTKRKRSDVAEKVAQRWKSVRYSAEMENMAPVNSNNDSDDCVIVSESKIIDLTNQEQDLSERIETNDTAKGAVFKLMKSDFYEREDFMGEVEDMITLKDIFGTETLKRSILFSFQYELDFLLRQFHQNVENITIVGQKGTIMPIEARAMDATLAVILKKVKLIEITMPPFASHHTKLIINFYDNGECKIFLPSNNFTSMETNLPQQVCWCSPLLKIGKEGLPVPFKRSLIEYLNSYHLKDIDELITKSVEEVNFAPLSELEFVYSTPSKFQSSGLLSFYNKLEKLSAGTSASDTAKHYLCQTSSIGTSLSRARDENLWTHLMIPLFTGIMSPPAKDTAGRKKAEILPTNSLINEYSQRKIKPYIIFPTEQEFVTSPLKWSSSGWFHFQYLQKKSYYEMLRNKFKVFYKQDPAMVTRRRGTTPAHSKFYMHCATNSAGPCDASQVFKELEWCLYTSANLSQTAWGTVSRKPRNYEAGVLYHSRRLANTRKVTCRTFTRDRRGCAGNPTHVAVPFTLPVIPYDLAEDECFCLARHEND
Protein: Rifin (C0H4Q5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFAVPLNILVTLCHANTHKKLSTTTCDIQTTRLLCECELYMSNYDNDPEMKRVMQQFHDRTTQRFQEYDERLQEKRQICKDKCDKEIQKIILKDKLEKELTEKFATLQTDIHSDAIPTCVCEKSMADKVEKGCLRCGSILGAAMPEVASIGATALYTLCQWQTKAIAAAIEKAMVQGAAKGLAAGNVKGVEIVLRGLRTLGVEDLYPELLKSIGTKIPYYDIARIANAIITKKTQMCGLTQSPANVPICKTIDIKFRLIRIDGQHFFDTTTGIKKGVTQVVGKATQTAEAEAAKVRTITSSKIITEEEGVINTIYMSNQTAIIASIIAVVVIVLIMVIIYFILRYRRKKKMKKKLQYIKLLEE
Protein: N-acetyltransferase ESCO acetyl-transferase domain-containing protein (Q4GZ53)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Structural maintenance of chromosomes protein
- Sister chromatid cohesion protein
- Structural maintenance of chromosomes protein
- SCD domain-containing protein
- Proliferating cell nuclear antigen
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
- EF-hand domain-containing protein
- Double-strand-break repair protein rad21 homolog, putative
Sequence:
MHNSVPASNTCSPFREETVSKRGKRSRGTGGDDKITRGTCSQPFSVITLPPGKLLEWLVCSPCRVYDVNLPRSRNNDNNISSLQCAVLPNFFVEYGGRSYSCVAKVCKPQLRKVLLRALAAVRQEMGSVDDIPHDSLLVVAVSPINAFSSECIHDASRTAMPRAREGCKIVGLCVARELSAPHRMHCESNWSHEKSEASGVGAAVQEGLGDCWEEDATRVGGTNNVRKAFCGVQLVWVADCYRRHGVAKVLVDTARRHISYGFEVPVERVAFSEPTSLGKLFAKSYSGRPDFLIF
Protein: Acid phosphatase (EC 3.1.3.2) (Broad-specificity phosphatase) (Fructose-1,6-bisphosphatase) (FBPase) (EC 3.1.3.11) (Q6MWZ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Phosphatase with a broad specificity. Can dephosphorylate a variety of substrates including phosphorylated sugars like fructose-6-phosphate (F6P). Is able to function in vivo as a fructose-1,6-bisphosphatase (FBPase) and to maintain gluconeogenesis when the classical FBPase GlpX is absent. Shows negligible phosphoglycerate mutase activity. Has no phosphatase activity against 3-phosphoglycerate, 2,3-bisphosphoglycerate, or hydrophobic substrates such as alpha-napthyl phosphate.
Interaction partners:
- Conserved protein
- Thymidylate synthase ThyA
- Putative isochorismate synthase MenF
- Uncharacterized protein Rv0525
- Possible SOJ/para-related protein
Sequence:
MGVRNHRLLLLRHGETAWSTLGRHTGGTEVELTDTGRTQAELAGQLLGELELDDPIVICSPRRRTLDTAKLAGLTVNEVTGLLAEWDYGSYEGLTTPQIRESEPDWLVWTHGCPAGESVAQVNDRADSAVALALEHMSSRDVLFVSHGHFSRAVITRWVQLPLAEGSRFAMPTASIGICGFEHGVRQLAVLGLTGHPQPIAAG
Protein: N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6) (pp-GaNTase 6) (Q6WV16)
Organism: Drosophila melanogaster (Fruit fly)
Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the diglycosylated Muc5AC-3/13 as substrate. Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Sequence:
MRRPNLKWIVKASLLLLISLTLFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKPQEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTALDNYSQDLVLSL
Protein: Secretin OutD (General secretion pathway protein D) (Pectic enzymes secretion protein OutD) (Type II secretion system protein D) (T2SS protein D) (Q01565)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of the multiple pectic enzymes (Probable). This subunit forms the outer membrane channel (By similarity).
Subcellular location: Cell outer membrane {ECO:0000250|UniProtKB:E3PJ86}. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane. {ECO:0000250|UniProtKB:P45779}.
Interaction partners:
- Type II secretion system protein C
- Pilotin OutS
- Type II secretion system core protein G
- Type II secretion system protein E
- Type II secretion system protein J
- Type II secretion system protein F
- Type II secretion system protein L
- Type II secretion system protein H
- Type II secretion system protein K
- Type II secretion system protein I
Sequence:
MLGKGIKKSWGWLGLTVLLLGSPCGWAAEFSASFKGTDIQEFINTVSKNLNKTVIIDPTVRGTISVRSYDMMNEGQYYQFFLSVLDVYGFSVVPMDNGVLKVIRSKDAKSSSIPLANNEQPGIGDELVTRVVPLNNVAARDLAPLLRQLNDNAGAGTVVHYEPSNVLLMTGRAAVIKRLVDIVNTVDKTGDREMVTVPLTYASAEDVAKLVNDLNKSDEKNALPSTMLANVVADGRTNSVVVSGEENARQRAVEMIRQLDRKQVVQGGTKVIYLKYAKALDLIEVLAGNGTSGNRNSSSSNASRPSSPRSGSSSNSNSSSGSSGSSSGSSSSSSSSSSMGFGSAFGSTSSSGGRTITIQGKEVTVRAHDQTNSLIITAPPDIMRDLEQVINQLDIRRPQVLVEAIIAEIQDADGLNLGIQWANKRAGMTQFTNTGIPISTAVIGTDQFRSNGTLTTAYASALSSFNGVTAGFYRGNWSMLLTALSSDSKNDVLATPSIVTLDNMEATFNVGQEVPVLTGSQTTSADNIFNTVERKTVGIKLRVKPQINEGDSVLLQIEQEVSSVADSNSSTNSSLGVTFNTRTVNNAVMVTNGETVVVGGLLDKTSVESNDKVPLLGDIPWLGSLFRSKSQEVRKRNLMLFLRPTIIRDPGQFQEASINKYRSFNNEQQQQRGEGNGVLDNNTLRLSGGNTYTFRQVQSSISDFYKPEGR
Protein: Steroid (22S)-hydroxylase (EC 1.14.14.178) ((22S)-22-hydroxycampesterol synthase) (6-deoxycathasterone synthase) (Cathasterone synthase) (Cytochrome P450 90B1) (AtCYP90B1) (Protein DWARF 4) (Dwarf4) (Steroid 22-alpha-hydroxylase) (O64989)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the C22-alpha-hydroxylation step in brassinosteroids biosynthesis. Converts campesterol (CR) to (22S)-22-hydroxycampesterol (22-OHCR, 22-hydroxyCR), campestanol (CN) to 6-deoxycathasterone (6-deoxoCT), and 6-oxocampestanol (6-oxoCN) to cathasterone (CT). Can also use cholesterol and cholestanol as substrates.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Steroid 5-alpha-reductase DET2
- Delta
- Protein BRASSINAZOLE-RESISTANT 1
- Protein BRASSINOSTEROID INSENSITIVE 1
- Protein BRASSINAZOLE-RESISTANT 2
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90C1
- 3beta,22alpha-dihydroxysteroid 3-dehydrogenase
- 7-dehydrocholesterol reductase
- Shaggy-related protein kinase eta
Sequence:
MFETEHHTLLPLLLLPSLLSLLLFLILLKRRNRKTRFNLPPGKSGWPFLGETIGYLKPYTATTLGDFMQQHVSKYGKIYRSNLFGEPTIVSADAGLNRFILQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRSISLNFLSHARLRTILLKDVERHTLFVLDSWQQNSIFSAQDEAKKFTFNLMAKHIMSMDPGEEETEQLKKEYVTFMKGVVSAPLNLPGTAYHKALQSRATILKFIERKMEERKLDIKEEDQEEEEVKTEDEAEMSKSDHVRKQRTDDDLLGWVLKHSNLSTEQILDLILSLLFAGHETSSVAIALAIFFLQACPKAVEELREEHLEIARAKKELGESELNWDDYKKMDFTQCVINETLRLGNVVRFLHRKALKDVRYKGYDIPSGWKVLPVISAVHLDNSRYDQPNLFNPWRWQQQNNGASSSGSGSFSTWGNNYMPFGGGPRLCAGSELAKLEMAVFIHHLVLKFNWELAEDDKPFAFPFVDFPNGLPIRVSRIL
Protein: Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) (Q0GE19)
Organism: Homo sapiens (Human)
Function: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17628207, ECO:0000269|PubMed:30082715}; Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17628207}; Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Golgi apparatus membrane {ECO:0000269|PubMed:29878199}.
Interaction partners:
- Hepatic sodium/bile acid cotransporter
- Sodium/bile acid cotransporter 5
- P3 protein
- Sodium-dependent organic anion transporter
Sequence:
MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLILFIIFSIQLSFMLLTFIFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV
Protein: Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7) (dMED7) (Q9GYV9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 21
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 19
Sequence:
MSNQETQVSSLPMPPERYIANYTDENIRRNRAPRPPPPPAQHEVYSMFGIQYNNDEMIRSLESQNIKRLIPIHFDRRKELKKLNHSLLVNFLDLIDFLILNPDSPRRTEKIDDISLLFVNMHHLLNEFRPHQARETLRVMMEMQKRQRVETAARFQKHLERVREIVNTAFSALPVLDDDDDSGGAKIKTEVDPLEANAAAKNDPSYQHDRMLCKLVDAIE
Protein: Periostin (A0A8I6AHK0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MVPLLPLSALLLLFLCDVDPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWDNLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTNEEREILIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKLVEPKIKVIQGSLQPIIKTEGPAMTKIHIEGEPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLQKFLQKEVSKVTKFIEGGDGHLFEDEAIKRLLQGDTPAKKIQANKRVQGSRRRSREGRSQ
Protein: WD repeat-containing protein 35 (Naofen) (A6N6J5)
Organism: Rattus norvegicus (Rat)
Function: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8BND3}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8BND3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BND3}.
Interaction partners:
- Intraflagellar transport protein 140 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 122 homolog
- Tetratricopeptide repeat protein 21B
- Intraflagellar transport 43
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport 52
- Intraflagellar transport protein 172 homolog
- Clusterin-associated protein 1
- Intraflagellar transport protein 56
Sequence:
MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKSLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKRLGNLQSESMKQAEVIAYFGRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKWMNAVQYYVKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE
Protein: Glycosyltransferase GtfC (EC 2.4.1.-) (P96560)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Catalyzes the attachment of dTDP-L-4-epi-vancosamine to chloroorienticin B to form chloroeremomycin in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. Also able to use dTDP-L-4-epi-vancosamine and devancoaminyl-vancomycin (DVV) to create epivancomycin. Acts downstream of GtfA.
Interaction partners:
Sequence:
MRVLLSTAGSRGDVEPLVALAVRLQGLGVEARMCASPASAERLAEVGVPHVPVGLQLEGMLLQEGMPPPSPEEERRLAAKAIDMQFDEVPAAAEGCAAVVAAGELAAAAAVRSVAEMLGIPYFYAAYSPNYLPSPHHAPPEDERTTPGVTDNKVLWDERGQRFAKRYGDTLNSRRASVGLPPVEDVFGYGYSERPWLATDPILAPLPPDFDAVQTGTWILPDERPLSAELEAFLAAGSPPVYLGFGSASGPGIDDAARVAIEAIRAHGRRIVLLSGWADLVRPDDGADCFSVDEVNLQVLFSRAAAAIHHGSAGTEHLATLAGIPQIVIPRHTDQPYYAERVADLGIGVALEGPVPTFDAMSAAVATALAPETRARATAVAGTIRTDGAAVAARLLLDAVSREKSAVLA
Protein: RE40275p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform C) (Q9VBN9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription factor Ouib
- LD26135p
- Serendipity locus protein beta
- Zinc finger protein Paris
Sequence:
MDPQTSKVCQTLNFTIARRTAEAPVKLVSHEVSLSDSTTSLELSNCCRLCLEEPYPNQMLDMTVIYDQEAALSYYDCYEICTKEDLRQNPKNEPRTLCKRCAVELKWAYDFHKKMAIANQQLREIFVATEANTEQEDDVEDEENEADMNEEFLMEEIEEKQETPIDSLEDIVPRNRHTGKSNCKFCHKEFRNHSRMAKHQMIHLANRPNFRCSQCDRVYLTKQALKVHVDSKHRQSGVHCDTCGKVFAIAKALEIHKRYHNRDFPYSCDLCDRRFAQRSHLTVHQQVKHSGSRFICEFPGCQKSFTSSSSLRNHECTHTAMPFECAHCHQSYPARNKLRMHLERKHNMVVQMEDLEEMRKFHIVRSKLVMAKIYSDQKESHHAKNDSAAISK
Protein: Amidohydrolase-related domain-containing protein (Q97BE1)
Organism: Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Interaction partners:
- S-methyl-5'-thioadenosine phosphorylase
- Polyamine aminopropyltransferase
Sequence:
MSIAISNAIIVTQNDNRDVYRGNVKIDGNKIQYVGKDEVDGDILIDGTNKVLMPGLINTHAHVGMSASKGLFDDVDLDSFLKKTFEYDSDRTSTGIFNSAKLGMYEMIGNGITAFVDLYYSEDIIAKAAEEIGIRAFLSWVTLDKELTTQIGDPVENAENFIRNHVGNKYVVPSVGVQGIYVANDDTFRRAMDLAEKYGTILHMHLSETRKEVYDAVKKLGERPIEHLHNIGILNKRVLAAHCVWATYHEVRLLSKDGVNVSWNSISNFKLGTGGIPPIPEMMRENVNVTIGTDSNGSNNSLDMFQAMKFSAISVKNYRWDASLMKAQEILDMATRNAARALQLNAGSIEVGKLADVVLLDATIPSMIPTNEANAVSNIVYSSSPQNVDTVIIDGEIKKINGKILGFHSNKFTNSEFK
Protein: DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) (G3V7Q0)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6PAL8}.
Interaction partners:
- Ras-related protein Rab-6A
- Ras-related protein Rab-11A
- DENN domain containing 4C
Sequence:
MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKKNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWLSNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAVMSPLRVSLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTSLVKGIDI
Protein: Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5) (Q9BYG0)
Organism: Homo sapiens (Human)
Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Beta-1,4-galactosyltransferase 4
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 2
- Beta-1,3-galactosyltransferase 5
- Beta-1,4-galactosyltransferase 3
- Beta-1,3-galactosyltransferase 1
- Beta-1,3-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 6
- Beta-galactosidase
Sequence:
MRMLVSGRRVKKWQLIIQLFATCFLASLMFFWEPIDNHIVSHMKSYSYRYLINSYDFVNDTLSLKHTSAGPRYQYLINHKEKCQAQDVLLLLFVKTAPENYDRRSGIRRTWGNENYVRSQLNANIKTLFALGTPNPLEGEELQRKLAWEDQRYNDIIQQDFVDSFYNLTLKLLMQFSWANTYCPHAKFLMTADDDIFIHMPNLIEYLQSLEQIGVQDFWIGRVHRGAPPIRDKSSKYYVSYEMYQWPAYPDYTAGAAYVISGDVAAKVYEASQTLNSSLYIDDVFMGLCANKIGIVPQDHVFFSGEGKTPYHPCIYEKMMTSHGHLEDLQDLWKNATDPKVKTISKGFFGQIYCRLMKIILLCKISYVDTYPCRAAFI