wanglab/gogpt-training-data huggingface dataset:
Protein: Glyoxylate and hydroxypyruvate reductase (A0A8J8XIM5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
ARLVNVCSCGSCETRATHEGVRHWPFAGPGQGCARPGHRVSARVGVGSAAEPLARCPVHPTSDTPAAALGRSCEVEQWNSDDPIPSKDLEQGVAGAYGLLCRLSDRVDKKLLDAAGANLRVISTLSVGVDHLALDEIKKRGIRVGYTPGVLTDATAELAVSLLLTTCRRLPEAIEEVKNGGWSSWSPLWMCGYGLSESTVGIVGLGRIGQAIARRLKPFGVQRFLYTGRQPRPQEAAEFQAEFVPIAQLAAESDFIVVSCSLTPATRGLCNKDFFQKMKNTAVFINISRGDVVNQEDLYQALASGQIAAAGLDVTTPEPLPPSHPLLTLKNCVILPHIGSATYKTRNTMSLLAANNLLAGLRGEPMPSELKL
Protein: Histone-lysine N-methyltransferase ATXR7 (EC 2.1.1.354) (EC 2.1.1.357) (Protein SET DOMAIN GROUP 25) (Trithorax-related protein 7) (F4K1J4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family. Required for histone H3 dimethylation on 'Lys-36' H3K36me2 at the FLC locus. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus. Involved in the control of seed dormancy and germination.
Subcellular location: Nucleus {ECO:0000269|PubMed:19726574}.
Interaction partners:
- Protein TRAUCO
- Protein RBL
- Lysine-specific demethylase ELF6
- Histone H3.1
- Histone H3-like 5
- Histone H3-like 1
- Histone H3-like 4
- Histone H3-like 2
- Histone H3.3
- Histone H3-like 3
Sequence:
MVAVDSTFPSHGSSYSSRRKKVSALEPNYFGSMCMGVYSDDVSISAREVAQDYSCDSCGDLATVSSACCNFDELCGLDSALEMGCRSNEDCRAGQEASGSGIASGLDKSVPGYTMYASGWMYGNQQGQMCGPYTQQQLYDGLSTNFLPEDLLVYPIINGYTANSVPLKYFKQFPDHVATGFAYLQNGIISVAPSVTSFPPSSSNATVHQDEIQTEHATSATHLISHQTMPPQTSSNGSVLDQLTLNHEESNMLASFLSLGNEHACWFLVDGEGRNHGPHSILELFSWQQHGYVSDAALIRDGENKLRPITLASLIGVWRVKCGDANCDEPVTGVNFISEVSEELSVHLQSGIMKIARRALLDEIISSVISDFLKAKKSDEHLKSYPPTSAVESISSRVINAEKSVVSNTESAGCKNTMNEGGHSSIAAESSKYTKSVGSIENFQTSCSAVCRTLHHHCMQIMWNAVFYDTVATHSSCWRKNKIWFRSSDISTVNYCKGSHTKYSDKPESFESFTCRVDSSSSKTAYSDEFDLATNGARVRGLSSDTYGTESVIASISEHVENELFLSLKTHLTDYTSILIKDGANNTTSSARDGKMHEGSFREQYNLEGSSKKKNGLNVVPAKLRFSNDFSDSQRLLQEGESSEQITSEDIIANIFSTALETSDIPVNDELDALAIHEPPPPGCESNINMPCLRYKYQPVRSKESIPEIKAYVSMALCRQKLHNDVMRDWKSLFLKCYLNEFLASLKGSHQVSRKETLALKKRKTVTRNKKLVQSNISNQTAEKLRKPCVGASEKVLVKRSKKLSDSHSMKEVLKVDTPSIDLSVRKPSQQKMRNTDRRDHCIIKDATKLHKEKVGKDAFSKVICDKSQDLEMEDEFDDALLITRLRRISRNKTKELRECRNAAKSCEEISVTAEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKNLSDARDEGTKSCNGAVKSFTEISGKEGDTESLGLAISDKVSHQNLSKRRKSKIALFLFPGFENTSRKCFTKLLSPEDAAKNGQDMSNPTGNPPRLAEGKKFVEKSACSISQKGRKSSQSSILKRKHQLDEKISNVPSRRRLSLSSTDSEDAVIKEDYDVRNEEKLPCHTSDKLQKGPNKLIRRRKPLAKHTTERSPIKDLSVDDGRPKPIALKPLEKLSSKPSKKKLFLSIPKSDGCARTSINGWHWHAWSLKASAEERARVRGSSCVHMQHFGSKSSLTQNVLSARTNRAKLRNLLAAADGADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPNVYCFCEQVPWIAKLKRRTWFSRRN
Protein: Golgi-associated RAB2 interactor protein 1B (Testis development protein NYD-SP18) (Q96KD3)
Organism: Homo sapiens (Human)
Function: RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation.
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:Q3UZD7}.
Interaction partners:
Sequence:
MLSSFPHRKTWRKSKKTVKVTRSYPTFPSLNAWEEFRGLLPVDGEPNPGAGLGVEEGLLCRVVHSPEFNLFLDSVVFESNFIQVKRGRNWRDVYKASNTMALGVTSSVPCLPLPNILLMASVKWHQGQNQTWNRPSIAPNIFLKRILPLRFVELQVCDHYQRILQLRTVTEKIYYLKLHPDHPETVFHFWIRLVQILQKGLSITTKDPRILVTHCLVPKNCSSPSGDSKLVQKKLQASQPSESLIQLMTKGESEALSQIFADLHQQNQLSFRSSRKVETNKNSSGKDSSREDSIPCTCDLRWRASFTYGEWERENPSGLQPLSLLSTLAASTGPQLAPPIGNSI
Protein: Olfactory receptor 10J5 (Olfactory receptor 16) (Q62007)
Organism: Mus musculus (Mouse)
Function: Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway. Acts also as a regulator of angiogenesis. Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway. Involved in sperm chemotaxis and motility.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28842679}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
Sequence:
MQRNNFTEVIEFVFLGFSSFGKHQITLFVVFLTIYILTLAGNIIIVTITHIDHHLHTPMYFFLSMLASSETVYTLVIVPRMLSSLIFYNLPISLAGCATQMFFFVTLATNNCFLLTAMGYDRYVAICNPLRYTIIMSKGMCALLVCGSLGTGLVMAVLHVPAMFHLPFCGTVVEHFFCDIYPVMKLSCVDTTVNEIINYGVSSFVILVPIGLIFISYVLIVSSILKIVSTEGQKKAFATCASHLTVVIVHYGCASIAYLKPKSESSVEKDLLLSVTYTIITPLLNPVVYSLRNKEVKDALCRAVGRNTS
Protein: Acyl-CoA:diacylglycerol acyltransferase (EC 2.3.1.122) (EC 2.3.1.20) (P71829)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAAAIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVIALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLNELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAPGSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGHNGGFWSAQLPAELTWFAPLLTG
Protein: RNA-binding protein rnc1 (RNA-binding protein that suppresses calcineurin deletion 1) (O74919)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mitogen-activated protein kinase spm1
- Tyrosine-protein phosphatase pmp1
Sequence:
MAYNHFSIPKNIEEKENSFFDVTFQDEPDETTSTATGIAKVSIPTPKPSTPLSTLTNGSTIQQSMTNQPEPTSQVPPISAKPPMDDATYATQQLTLRALLSTREAGIIIGKAGKNVAELRSTTNVKAGVTKAVPNVHDRVLTISGPLENVVRAYRFIIDIFAKNSTNPDGTPSDANTPRKLRLLIAHSLMGSIIGRNGLRIKLIQDKCSCRMIASKDMLPQSTERTVEIHGTVDNLHAAIWEIGKCLIDDWERGAGTVFYNPVSRLTQPLPSLASTASPQQVSPPAAPSTTSGEAIPENFVSYGAQVFPATQMPFLQQPKVTQNISIPADMVGCIIGRGGSKISEIRRTSGSKISIAKEPHDETGERMFTITGTHEENEKALFLLYQQLEMEKDRRSH
Protein: Somatotropin (Growth hormone) (P06880)
Organism: Mus musculus (Mouse)
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Subcellular location: Secreted.
Interaction partners:
- Prolactin
- Growth hormone receptor
- Prolactin-5A1
- Prolactin-6A1
- Appetite-regulating hormone
- Leptin
- Somatoliberin
- Erythropoietin
- Pro-opiomelanocortin
- Granulocyte colony-stimulating factor
Sequence:
MATDSRTSWLLTVSLLCLLWPQEASAFPAMPLSSLFSNAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKEEAQQRTDMELLRFSLLLIQSWLGPVQFLSRIFTNSLMFGTSDRVYEKLKDLEEGIQALMQELEDGSPRVGQILKQTYDKFDANMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
Protein: Gamma-aminobutyric acid type A receptor subunit gamma2 (A0A2R8Q1Q9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MVMMASLHFSSKCLNAMAIPAVTLKLFLWAFLIAHLPLSSVQLESDDDEVTNKTWVLTPKVYESDVTHILNSLLDGYDNKLRPDIGVKPTVIHTDMFVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTMKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRILYTLRLTIDAECQLKLNNFPMDEHSCPLEFSSYGYPKEEIVYKWKRSSVEVGDIRSWRLYQFSFVGLRNTSEVVRTVSGDYVVLTVFFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALIEYGTLHYFVSNRKPSKKSDKKKKNPQAPTVDIRPRSATAIQMNNATQMQERDEEYGYECLDGKDCTSFFCCFEDCRSGAWRHGRLHIRVAKIDSYARIFFPTAFGLFNVVYWFSYLYL
Protein: Histone H4 (Q8NIG3)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone acetyltransferase type B catalytic subunit
- Histone H3
- Histone H2A
- Candida glabrata strain CBS138 chromosome I complete sequence
- Histone chaperone ASF1
- Histone acetyltransferase GCN5
- FACT complex subunit SPT16
- Histone H2A.2
- Histone H2A.1
- FACT complex subunit POB3
Sequence:
MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEEVRAVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG
Protein: GPI transamidase component GPI16 (P38875)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the GPI transamidase complex. Involved in transfer of GPI to proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11598210}; Single-pass type I membrane protein {ECO:0000269|PubMed:11598210}.
Interaction partners:
- GPI transamidase component GAA1
- GPI transamidase component GPI17
- GPI-anchor transamidase
- GPI transamidase component GAB1
- GPI ethanolamine phosphate transferase 3
- Glycosylphosphatidylinositol anchor biosynthesis protein 11
- GPI inositol-deacylase
- GPI mannosyltransferase 3
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19
- Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit
Sequence:
MILTLAYFMLGTLLLGVFAEDTVSQIGINDSLWYPYDEALVLKPLPNNDLLLSFAFQLQSEPFDPAVSSMSYDAYEHYTTFPRAIPPLLESTATRQFHLRFTRGFWDALSWGQLPHAGKEAGASGVELWSQVQAMDQEQAFHNWKKLSNSLSGLFCSSLNFIDESRTTFPRRSYASDIGAPLFNSTEKLYLMRASLPNEPICTENLTPFIKLLPTRGKSGLTSLLDGHKLFDSLWNSISLDIATICSEDEDALCHYEMDARIEMVTHVPSALARGERPIPKPLDGNTLRCDTDKPFDSYQCFPLPEPSQTHFKLSQLFARPINNGNLFANRPTRICAEVDRSTWTAFLSVDDTIFSTHDNCFDLSNDQNEGGSGYDFILESTDTTKVTPIVPVPIHVSRSLTGNGQDRGGMRIVFHNDNDTPVKLIYFESLPWFMRVYLSSLQITSTTSPQLQENDIILDKYYLQAADRKRPGHLEFTMLIPANTDIVMTYQFDKALLQFAEYPPDANHGFEIDAAVITVLSLESSSSLYEMRTSTLLLSLSTPDFSMPYNVIILTSTIMGLIFGMLYNLMVKRMVTVEEADKITLQSGLKYKLLKLKEKFLGKKKTKTD
Protein: Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) (Q8N8E3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes around spindle poles in some cells. {ECO:0000269|PubMed:21399614}.
Interaction partners:
Sequence:
MEVGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRTERQRCALWIRKLCEPSGTGAGIMGRKNRNLYAKLLLHMLKRGALEGPFTHRPEPGTLKILPSYMSIYFDEPNPARAKGSSPEGLPAWVLGELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGRR
Protein: Glucosylceramidase (EC 3.2.1.45) (B2R6A7)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome membrane {ECO:0000256|ARBA:ARBA00004207}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004207}; Lumenal side {ECO:0000256|ARBA:ARBA00004207}.
Interaction partners:
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ
Protein: Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (P56401)
Organism: Ovis aries (Sheep)
Function: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P29972}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29972}.
Interaction partners:
Sequence:
MASEFKKKLFWRAVVAEFLAMILFIFISIGSALGFHYPIKSNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAIMYIIAQCVGAIVATVILSGITSSLPDNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRRDLGDSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
Protein: Flavin-dependent halogenase malA (EC 1.14.-.-) (Malbrancheamide biosynthesis cluster protein A) (L0E155)
Organism: Malbranchea aurantiaca
Function: Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of malbrancheamide, a dichlorinated fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2.2.2]diazaoctane core. The first step of malbrancheamide biosynthesis involves coupling of L-proline and L-tryptophan by malG, a bimodular NRPS, to produce L-Pro-L-Trp aldehyde through reductive offloading. This compound undergoes spontaneous cyclization and dehydration to give a dienamine which is reverse prenylated at C-2 by malE. The other prenyltransferase present in the cluster, malB, displays modest activity, suggesting that may be a redundant gene in the pathway. Subsequently, a [4+2] Diels-Alder cyclo-addition catalyzed by the bifunctional enzyme malC forms the characteristic bicyclo[2.2.2]diazaoctane ring of premalbrancheamid. Finally, the flavin-dependent halogenase malA catalyzes the iterative dichlorination of the indole ring of premalbrancheamide to yield C-9 monochlorinated malbrancheamide B, C-8 monochlorinated isomalbrancheamide B, and dichlorinated malbrancheamide. MalA is also able to brominate premalbrancheamide at C-9 to yield malbrancheamide C, and, to a lesser extend, at C-8 to yield isomalbrancheamide C. Finally, malA can brominate C-9 monochlorinated malbrancheamide B at C-8 to yield malbrancheamide D, or C-8 monochlorinated isomalbrancheamide B at C-9 to produce isomalbrancheamide D.
Interaction partners:
Sequence:
MAPTPKYTFTERAAAGNLSDAEILNSNNPTGSELPDESDVVVGGAGIHGLIYALHASKYKPNNLKISVIEKNTRPGYKIGESTLPIFYTWCKLHGISAAYLLRLFGLKDGLCFYFLDRENQGQYTDFCSVGAPGLVLASLQIERPMSELLFTILAQRNGVNVYHGREVDFKSTVVQGGGQGNKIAVSRGKYDSTPKTIDSALFVDATGRFRQFCSKKAPRHRFDGWNCNAFWGYFTAPKDESKIPFDLYEGDHTNHLCFPEGWVWVIRLPSWEGSLIANLMDMVTYILECADAGVPGDELPSSEELARMFGLKFQWVTSIGFAVRNDVKYPEDLSAYGTREAEQKFNYFVQKYELLQQFMSNFELIENLYGPGTTWFIRKTLAYQSPVVSGPGWLAIGDACGFTNPLYSPGINVGMSTSTWAAQLSHRIVEIGKSAPADAAESSIRKLLVPYDDYCKSLVPALEQMNRFNYVCYRDTRLGPQVACLWQFFAGIERYLSDVNIETFAHYAIKWVWGAMVPEYQQVAQKCIEHIETVPLDERLPDAMVDELLAFSNRIKSAAVAADDFSLRWDAILRSFDRSLNFVEGKTSRDIYTRQCSGCGAWLQLRPDWKKCHSCGLLGTEPQTAVTFDPPLTAEEEALLYAAWNTAPKYDPSKELKLPTPTRPAA
Protein: Rothein 2.2 (P86510)
Organism: Litoria rothii (Roth's tree frog) (Hyla rothii)
Function: Lacks antimicrobial activity. Does not inhibit the formation of NO by neuronal nitric oxide.
Subcellular location: Secreted {ECO:0000269|PubMed:16124032}.
Interaction partners:
Sequence:
AGDDETLLKPVLNSLDNLVSGL
Protein: ATP-dependent RNA helicase uap56 (EC 3.6.4.13) (O13792)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).
Subcellular location: Nucleus {ECO:0000269|PubMed:15990877}.
Interaction partners:
- mRNA export protein mlo3
- Uncharacterized RNA-binding protein C106.12c
- THO complex subunit tho5
- Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22
- Protein mlo1
- THO complex subunit tho7
- Pre-mRNA-splicing factor cwf28
- Uncharacterized protein P25A2.03
- mRNA export factor mex67
- THO complex subunit Tho3
Sequence:
MASAQEDLIDYEEEEELVQDQPAQEITPAADTAENGEKSDKKGSYVGIHSTGFRDFLLKPELLRAITDSGFEHPSEVQQVCIPQSILGTDVLCQAKSGMGKTAVFVLSTLQQIEPVDGEVSVLVLCHTRELAFQIKNEYARFSKYLPDVRTAVFYGGINIKQDMEAFKDKSKSPHIVVATPGRLNALVREKILKVNSVKHFVLDECDKLLESVDMRRDIQEVFRATPPQKQVMMFSATLSNEIRPICKKFMQNPLEIYVDDETKLTLHGLQQHYVKLEEKAKNRKINDLLDSLEFNQVVIFVKSVSRANELDRLLRECNFPSICIHGGLPQEERIKRYKAFKDFDKRICVATDVFGRGIDIERVNIVINYDMPDSPDSYLHRVGRAGRFGTKGLAITFSSSEEDSQILDKIQERFEVNITELPDEIDVGSYMNA
Protein: IQGAP3 protein (Ras GTPase-activating-like protein IQGAP3) (A0A0F7EVQ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGDGVQQRSVYERLTAEEMDEQRIQNVAYQYLCRLEEAKRWMEECLKEDLPAPTELEEALRNGVYLAKLGHCFAPRVVPLKKIYDLDQQRYKVSGLQFRHTDNINHWRNAMMEVGLPTIFHPETTDVYDKKNMPRAVYCIHALSLYLFRLGLAPQIHDLRGKVKFTEEEINNMKLELDKYGIQMPAFSKIGGILANELSVDEAAVRAAVIAINEAVDRGCVQTTAQTLRNPNAMLSALQDPLMPVYQQMLQQARVQKAARARTNTSEEKDIYEEYLTQREIQDSINTVNMRAAVERVDEALDCSDAQALLCALQNSSLALRGLIRDHASWYLEQLSADREQKALDLGCVDPLEREELQEGINMANEDAKRDQTMQQAVCKINEAVRRGEARQTVRALMNPDAHLPDVYPFAAELYQRELAPLQRQCPQAELQQEELYVAVEMLSAVALVNQALEVRDFGAFSSTVISPAAGLTDIDDSLIQRYFEELCELKRSAGKSLLSWNDLQTGLNAVNTSAHEEHEQIVTIGLINQALSRSDPQKTLSALMLPSSGLEDVQPLNARRYHDLLIRARRHKAELSRDPGAELWLADIQEGVRLANQDTQKALKMCLGLAAVNQAVKECKASQTLRVLRLPEVALRSVVSECADGYQTELTALLRAKTLEGDNRSPWMMTKLADSSSYFFHLQKLEGSWERPQGFVQNSTFLTHEEIQAVCSGVTAAHSRDVQWRASEPLVLQLQARMRGFLLRLKLQERLHFLNTQLPAVITIQSHWRRFTQQREYKRRLQYLYRNWRAIVKIQATVKMWIARRRYLARLAYFRRHVGAIIRIQAFFRASRTREEYRLLVHSSTPPLSVVRKFAHLLEFGDSDIRQEGELLRLREDVVRTIRANRQLEADLDLMDLKIGLLVRNRVTLQEVVSHCKKLTKKNKEQLSDMMALDKHKGLKALSKEKREKLEAYQHLFYLLQTQPLYLAQLIFLMPQNKSTRFMETVIFTLFNYGSDCREAFLLLQLFTAALRHEITVKVDRPQEVITGSPTVIKMLVSFYRHARGQNALKDILGPAIRDVLQDRTLNIRTDPVEIYKSWVNQSESQTGQKSCLPYEVSVDQALSHSEVQHRLNVSITNLKNLTERVLNAIISNTHRLPYGLRYTAKVLRDTLQEKFPQATEDELYKIVGNLIYYRYMNPAIVAPDGFDVVEFSAGSALLPGQRRTLGSIARILQHSAALKHFQGDSAHLHALNQYITQTHSRFRKFLRAVCDVPEPEERFSIDEYSETLILNRPVIYISISELLNTHRLLLEHQDSLCSDQSDPLLQLLNDLGSVPSVQELVGEGHLNSADPNTEQTLDKMEVSLTLTSKFDVFKSSDDQPDARGILLSTKQLIIDVIRTQPGDTLHEVLQVSASRDQEVQHGWLMHQRAQRDARTPEKMKRNQSLIADGRLTLEEKKRKIQRNIRRLEAIGTLRPHDAHTHILQLIAKDIRHQRVYRQRRQAELVKLKHTLNSLNSKSCFHSEQVDYYSQYINTCLHNLTNSKVSKKKVSDNKGKKKQATLTYTAARLHEKGVLLEIEDLPVTQFKNVIFDIVPGEEDGVFLVKARFMGVDMEKFPLKYQDLLQLQYEEVAVMKMFDKAKVNVNLLIFLLNKKFFKK
Protein: Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Q38SD2)
Organism: Homo sapiens (Human)
Function: Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16243488, ECO:0000269|PubMed:36040231}. Cell membrane {ECO:0000269|PubMed:36040231}; Peripheral membrane protein {ECO:0000305|PubMed:36040231}.
Interaction partners:
- Growth factor receptor-bound protein 2
- SHC-transforming protein 1
- BAG family molecular chaperone regulator 5
- Tyrosine-protein kinase ABL1
- Heat shock cognate 71 kDa protein
- Leucine-rich repeat serine/threonine-protein kinase 2
Sequence:
MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
Protein: Ret oncogene, isoform A (Ret oncogene, isoform B (EC 2.7.10.1)) (Ret oncogene, isoform C) (Q7KT06)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Glial cell line-derived neurotrophic family receptor-like, isoform E
- Fibroblast growth factor
Sequence:
MESTTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEKHLSKTISFRFSSLLNLSETKEVSPGWQAEDAV