wanglab/gogpt-training-data huggingface dataset:
Protein: Supporter of activation of yellow protein (Protein enhancer of yellow 3) (Q9VWF2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential transcription regulator during early development. Coactivates transcription of some euchromatin genes and repress transcription in of euchromatin genes translocated to heterochromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:15616585}. Cytoplasm {ECO:0000269|PubMed:15616585}. Chromosome {ECO:0000269|PubMed:15616585}. Note=On polytene chromosomes, it mainly localizes to transcriptionally active euchromatin sites but also localizes to heterochromatic regions such as the chromocenter and the chromosome 4. Cytoplasmic in nursing cells and growing oocytes.
Interaction partners:
- GH08712p
- Polybromo
- Brahma associated protein 170kD
- Brahma associated protein 155 kDa
- Bromodomain containing 7/9
- Brahma-associated protein of 60 kDa
- Brahma associated protein 111kD
- ATP-dependent helicase brm
- Brahma associated protein 55kD
- Trithorax group protein osa
Sequence:
MNDLRQQQMVAATSSSGSESGTAVESAAATSTAGSAGAAGRPQSNCSANSNAKSVAASSTSEEEQRVSSTSSPAQRDQQLNADRDREQEPEPQQQQQREEALQHQHNQPGHITSTTASPPPTLPPPTTPCDDAPSTTGASASASSASGEAPSAASAAGAAGGPMAATALEVESEERDGHKIILKLSKHANPNSNANESQPGGDERRVEPLRIQLPCGGAEGGLVAKQQDAFDADASSCSSSCAEDEVATTLGQQLRNTPHIVPKLTIRAANERRVGSVVPKLTIKLPENPAASGSNSNSGSCSAAVSGAQSAMPAKNDAHLSSLSPASASSSSASSSSSSSSSSSLAEMQTVPKLMIKTTLAGSSCISSSEELPQQQQQIPKLTIKTGGGGQEHVHTVIMTHDLNNAQSIPKLTIKTKSIEMIEDEQAAKLEQQLQPLPKLTIKNLCSPKHKVRAVLEEKPPTAASKLAIPKPTPNPTPAPMTNGGESNSSSQEFCGFSDPDADIAAPASDDVRRNSDDMVIDDSLSKEHDPKIFHNLPPMPASNGIASGGSKASKASKSAQSQHNVVDMVDLTSSPSPGSSPTHVPNNFTGRISPKGLLIDCLRMQTAIGCYVPEEADSRVRPAASPNSNILLSQLTAPAKSFTTTTPKSKSSKYPQLTERLMANGSGTGGGSVIAAESEAVVGPLPAANPAQSIIESIEILDTPDGSPRVAYMDEDSNPMLNKHLQTIHKLAMDHGVEQRMDTQDNNNENHLKRTNSEGNESPSSRLPPSKQRRLDNDENDQQTQNCHDPARKCSESLQALPPSHRSRKQKHERILNTDLEGSLFPPTQQQSISTPDQNGALSSEVEGEDAKAQDPLEPATPQPPPVATPAGTGKKRGRPKRIQNQSSPDGGGAVTPKPGTPQEEANSAVKSRRVQLLRKRLAIDMVSVGQEQADMKAKEKESSVGVPNARVEDGLAETLESPKTRDHRPLRATRRTTTSTNTNLQPTPKSTRKRQSKASVQQSQLPPPTMAQFGSSESESNNNNNSSISFALSAQIDLTMCSSSSSTSSGAAANQQVIGGSGSSSMLPPTTILSSSDPLPDVIFQPNDFSSIMATQQLRSSRPSSISCGSTGGSQPDCHDEDNYTSALDNSGDETALPMPPTRGRGRGRRSRGGRGRGSSSVDRAVSVGGTASTTPATQPRAPRMSRGASAVAKAIAMSRPRCVGGLKHQPDPERLKGLFSPSPQVFEEDTRMSADLSNSNQSMASLMEPPLTPQKQPDFLNNEESQSSMVSNVSMMDSNQGQSADAILGSALKRPKKKKMETCVAEDTDYSASSIAEYDWPPPKGCCPSKNRDTFMIQEQVALYLGITSFKRKYPDLPRRSVDMEERNWLQEKGLVSEKLCDLGITAVWASDILDIMYADFFDKYEEYKEYIRRKHLREIEAKQKALGLTVGAGRGLQARDRAMLSATKWNAYFNKSRKDERQSCMDLQTFTINQPQPRTAPTCTRLERSTSDLIRAVAEEANIPAPPNLLPPRDYDEAFRNSDYAYPLTVVPDQFSMAYRQFEPAELRAYPLDTALDKPPTDLMAQLLQAKSEAVGSDEIKTSAPAPKDLGQEQSAIKSVTVTAPVRRSRRSTRQQTDKVRTASSSSTSSAQSVSSASSGNGSSSDTESGDESDFSSTSSCSSSTGASSGAGSEDEDGNECSSSVRLSTCGVCLRSQHRNARDMPEAFIRCYTCRKRVHPSCVDMPPRMVGRVRNYNWQCAGCKCCIKCRSSQRPGKMLYCEQCDRGYHIYCLGLRTVPDGRWSCERCCFCMRCGATKPEGLPQVAALSQASGGPSANGDRSKAARNKRLKWVHEYRIDHVTKIREHAAMFCVPCARNKPAKRQSAAGAAGAAAVTPVLEATSAQTDDSPMPSPGLTTNGGRALSPTAALSPKAAVPVASLPPVLEATTVTTNIAGTIGRRQAGNAVNITTMQCSSSSSSNFSGNGVTEDAANVTATGTATAAAGAPAATPIGIAPPPVVA
Protein: Iron-sulfur cluster assembly protein 1 (AtISU1) (AtIscU1) (Protein ISCU-LIKE 1) (NifU-like N-terminal domain-containing protein ISU1) (NifU-like protein ISU1) (O49627)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:15792798, ECO:0000269|PubMed:17417719, ECO:0000269|PubMed:19865480}. Cytoplasm, cytosol {ECO:0000269|PubMed:19865480}. Note=Localizes to the cytosol when interacting with HSCB. {ECO:0000269|PubMed:19865480}.
Interaction partners:
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Frataxin, mitochondrial
- Cysteine desulfurase, mitochondrial
- NifU-like protein 1, chloroplastic
- NifU-like protein 4, mitochondrial
- NifU-like protein 5, mitochondrial
- Heat shock 70 kDa protein 9, mitochondrial
- Cysteine desulfurase 1, chloroplastic
- Adrenodoxin-like protein 2, mitochondrial
- Adrenodoxin-like protein 1, mitochondrial
Sequence:
MMLKQAAKKALGLTSRQSTPWSVGILRTYHENVIDHYDNPRNVGSFDKNDPNVGTGLVGAPACGDVMKLQIKVDEKTGQIVDARFKTFGCGSAIASSSVATEWVKGKAMEDVLTIKNTEIAKHLSLPPVKLHCSMLAEDAIKAAVKDYKEKRVKTNGAAAAGETTQA
Protein: SET domain-containing protein (Q38BM6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRPYFPGANGVLRSHCISCFVSRRQQSAKKNGTSADEGKQTPPYCHTGENYCGSASVPRTEAVNARMMQTSAAYPRVHVTLHDPQKSKSEEADELSRCGGGEGVNGINDKAETVFGGNRVGDLSENEVRAFLFRKEREIAHHHQQRNSTIPYPPHPDDVVPQFRRIKRHQQMLVVALDPDYPVYDRRDNVPELPPAQSHPWVKKTPTGPFIVHGDGQLGVVGTGEVGFEDAFTSDNTTEVAAATMGEVMLPLPRDFRGLQHRSTLHQSLPSCNGKVLQETVIKNSFALTGRGVFTTRDVSAGETIMIVRNTARNLGVKSEIERLVEMCTDVLSDTYNNFCNGNPQKLDFLHDWVLTGQPSSLLLHWPRSATKQVLECIGGAEVLRALELHEIHIARLAAIMDMNSFLVESSYAVRKGMAYFPEAGFFNHSCSPNATYDVIPAHTFCETDYYVDELGDSANAAFCATNYGEYTKSSNNDIVDATSGRNTTSDTKSDRDASEDECMEDVHNADGNQIIPSGTVEYLFCCRATADIPAGSEILISYVPPEWSFDNRQYVLHDRYRFWCKCPKCAPTLDSKYARTPRLLVAMLIFSIFLQLLVMRQRDMEHATMRERETGEEEEMRHGESGREKLKRRARGLFELLEESRQEEMYTPDRGPIPERVAQDPWARPAR
Protein: NAC domain containing protein 24 (T13D8.22 protein) (O80756)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA replication ATP-dependent helicase/nuclease JHS1
Sequence:
MEEDAAFDLLKAELLNAEDDAIISRYLKRMVVNGDSWPDHFIEDADVFNKNPNVEFDAESPSFVIVKPRTEACGKTDGCETGCWRIMGRDKPIKSTETVKIQGFKKILKFCLKRKPRGYKRSWVMEEYRLTNNLNWKQDHVICKIRFMFEAEISFLLAKHFYTTSESLPRNELLPAYGFLSSDKQLEDVSYPVTIMTSEGNDWPSYVTNNVYCLHPLELVDLQDRMFNDYGTCIFANKTCGKTDRCINGGYWKILHRDRLIKSKSGIVIGFKKVFKFHETEKERYFCGGEDVKVTWTLEEYRLSVKQNKFLCVIKFTYDN
Protein: Selection and upkeep of intraepithelial T-cells protein 1 (Skint-1) (Immunoglobulin-like and transmembrane domain-containing protein expressed in skin and thymus protein 1) (A7TZE6)
Organism: Mus musculus (Mouse)
Function: May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGSTGLCFYGHCIVMFLLQMVTASSEPFIVNGLEGPVLASLGGNLELSCQLSPPQQAQHMEIRWFRNLYTEPVHLYRDGKDMFGEIISKYVERTELLKDGIGEGKVTLRIFNVTVDDDGSYHCVFKDGDFYEEHITEVKITAINLQVQIHVHPPNTKGVIVECHSGGWFPRPLMQWRDRRGEVIPAASKSHSQGRDKLFNMKISLLISESFFQKVICCLQNPLTGQEERTSVILSDAFFSWNRIWKMILGIILSMMVVSIFVFSCLLHHEHKVCKWKWDAPWIKGLLIMTSSMVTVVLVMVYLHMKQRVPVSDVHFELDTLWVEDISVILCSLMVPATMLVSYTYFRLKDWCQHNHAQRVFTSN
Protein: SPRY domain-containing SOCS box protein 4 (SSB-4) (Q96A44)
Organism: Homo sapiens (Human)
Function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2. Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1.
Subcellular location: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
Interaction partners:
- Elongin-C
- Cullin-5
- Cytokine-inducible SH2-containing protein
- Elongin-B
- RING-box protein 2
- PRKC apoptosis WT1 regulator protein
Sequence:
MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ
Protein: Junction adhesion molecule like (E9PNS8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQS
Protein: RING-type domain-containing protein (Q9U5C1)
Organism: Caenorhabditis elegans
Interaction partners:
- MATH domain-containing protein
- Cytochrome P450
- Peroxidase
- Fungal lipase-like domain-containing protein
Sequence:
MSFLKCGVCTEDYSNVITNRHPKNLTCGHSICKACSSKLVSNFKILCPFCRKTTELRENENLQTNFALLEAISLFNDINESVTEPRSSGAPPNCEEHTYNLAEFVCISPNCSSRSKLMCRTCEEFGVHAGHRKGLLQVEAKKVRQNLLERQRKLQVNKKQVDDKIQALEKAALKKNDELYKEKYDEITRHYDRIRSSVAEREKTSKEVLKKSVLTSEEDNRMGQISNHVIRHLLEKKCEEVEQLVGMTDFELYRVKDKVDWNDESFSFSDVKEKPPMELKTLHVKLPEFRFEDSS
Protein: Thioredoxin domain-containing protein (Q57X68)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTDTIDVTTYCDDKSFGQVAPALSALEPIRGDKVELENGKVYVLYFFNTFYRGADVVNEEFTVLSEKYGPKGVVFVAISNDADKAKTEKYLGKEIVDENTKKPLRLAPPHILFDDKKATGKTYADVANLSVMSCPMAFIVAADGKIVWRQQFLQSFTITQSNFEAQLQHVLAGEALESNGPRPVVQVEEEEAEVDAEMSLF
Protein: Cytochrome P450 4X1 (EC 1.14.14.-) (CYPIVX1) (Q8N118)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6A152}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q6A152}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADPH--cytochrome P450 reductase
- NADPH-dependent diflavin oxidoreductase 1
- Cytochrome P450 4Z1
- Methionine synthase reductase
Sequence:
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLSEC
Protein: Laccase-4 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 4) (Diphenol oxidase 4) (Protein IRREGULAR XYLEM 12) (Urishiol oxidase 4) (O80434)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lignin degradation and detoxification of lignin-derived products (By similarity). Required for secondary xylem cell wall lignification.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Phenylalanine ammonia-lyase 1
- Cellulose synthase A catalytic subunit 8
- Cellulose synthase A catalytic subunit 4
- COBRA-like protein 4
- Cellulose synthase A catalytic subunit 7
- Transcription factor MYB63
- Beta-1,4-xylosyltransferase IRX9
- Protein IRREGULAR XYLEM 15
- Transcription factor MYB46
- Probable galacturonosyltransferase 12
Sequence:
MGSHMVWFLFLVSFFSVFPAPSESMVRHYKFNVVMKNVTRLCSSKPTVTVNGRYPGPTIYAREDDTLLIKVVNHVKYNVSIHWHGVRQVRTGWADGPAYITQCPIQPGQVYTYNYTLTGQRGTLWWHAHILWLRATVYGALVILPKRGVPYPFPKPDNEKVIVLGEWWKSDTENIINEALKSGLAPNVSDSHMINGHPGPVRNCPSQGYKLSVENGKTYLLRLVNAALNEELFFKVAGHIFTVVEVDAVYVKPFKTDTVLIAPGQTTNVLLTASKSAGKYLVTASPFMDAPIAVDNVTATATVHYSGTLSSSPTILTLPPPQNATSIANNFTNSLRSLNSKKYPALVPTTIDHHLFFTVGLGLNACPTCKAGNGSRVVASINNVTFIMPKTALLPAHYFNTSGVFTTDFPKNPPHVFNYSGGSVTNMATETGTRLYKLPYNATVQLVLQDTGVIAPENHPVHLHGFNFFEVGRGLGNFNSTKDPKNFNLVDPVERNTIGVPSGGWVVIRFRADNPGVWFMHCHLEVHTTWGLKMAFLVENGKGPNQSILPPPKDLPKC
Protein: CoxD (Q51326)
Organism: Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans)
Interaction partners:
Sequence:
MRHHAERDKVAERLAYAGYIPDRDLATAVWLMESLSRPLLLEGEAGVGKTEVALTLAQANGARLIRLQCYEGLDQNAALYEWNYQRQLLAIKTRESRADAVDVIEDHIFSEKFLLERPLLAAIRQPKSAVLLIDEVDRADEEFEAFLLELLSDYQVSIPELGTIHATTIPQVILTSNGTRELSDALRRRCLYHYVDYPDVEREARIITTRMPNIDVALALQIARMIEGIRKEDLRKSPGVAETLDWAAALAGLGVEDLRAEPEAVFETMMCLIKTVEDKSRVTREVSDRLLGKVA
Protein: G protein-activated inward rectifier potassium channel 3 (GIRK-3) (Inward rectifier K(+) channel Kir3.3) (Potassium channel, inwardly rectifying subfamily J member 9) (P48543)
Organism: Mus musculus (Mouse)
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G protein-activated inward rectifier potassium channel 1
- G protein-activated inward rectifier potassium channel 2
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid type B receptor subunit 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
Sequence:
MAQENAAFSPGSEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGAGDGADKEHNGCLPPPESESKV
Protein: Uncharacterized endoplasmic reticulum membrane protein YNL046W (P53956)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YLR049C
Sequence:
MEHVSKRSIGQFFKRKTSTVDGSKSQKCGTTNQLRKLLHKRRVQKQAVPVESQYRIPGDFRDNQSVRVKNSMYNSSPSVTPSTHHINERYVRYDINTRPLVVVLAISIVFFGCLLVLKDIIIQSSENILSVSKWKIIGASFMGTPYTGLLTGLVGPLLSPFSAVSSWLSFIF
Protein: Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) (Q8TEU7)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
Interaction partners:
- Ras-related protein Rap-1A
- Junctional adhesion molecule A
- Rap guanine nucleotide exchange factor 2
- Tyrosine-protein phosphatase non-receptor type 13
- Ras-related protein Rap-1b
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Ras-related protein Rap-2a
- Ras-related protein M-Ras
Sequence:
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
Protein: Immunity associated protein 1 (A0A090N8Z4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAVAEVGPD
Protein: Hemoglobin subunit beta-1 (Beta-1-globin) (Hemoglobin beta-1 chain) (Hemoglobin beta-major chain) (P02088)
Organism: Mus musculus (Mouse)
Function: Involved in oxygen transport from the lung to the various peripheral tissues.
Interaction partners:
- Hemoglobin subunit alpha
- Haptoglobin
- Hemoglobin subunit zeta
- Globin b2
- Globin d1
- Globin d2
- Hemoglobin subunit epsilon-Y2
- Hemoglobin subunit beta-H1
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
Sequence:
MVHLTDAEKAAVSCLWGKVNSDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH
Protein: AP complex subunit sigma (A0A2R8YGH5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004180}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
Interaction partners:
Sequence:
MRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA
Protein: Putative proline--tRNA ligase C19C7.06 (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) (O60155)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable glutamine--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Probable glutamate--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, mitochondrial
- Probable methionine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, mitochondrial
- Putative leucine--tRNA ligase, cytoplasmic
- Probable asparagine--tRNA ligase, cytoplasmic
- Aspartate--tRNA ligase, cytoplasmic
Sequence:
MSVDSLVSCLEQLITDDLKLVEHQEVSNGATWASALQSTKDVPSHALTKTIVLKPKTAKSQTVVPIILAALETTSTPSGIAAKAVGSKEARMAAADLVEEVFGIPPTDVGIFSVNKENASKVHVVLDAALIQHNGLLAFHPSSSAKTVFVSPAAVQTYLKSVGVNPIIVDFSAPGSATAPSKPAAQKKKAEPSKNDAAIENAALIGITVRKDADFPNWYQQVLTKSDMIEYYDISGCYILKPWSYSIWEAIQGWFDKEIKKLGVRNGYFPLFVSSKVLEKEKDHVEGFAPEVAWVTRAGTSELDEPIAIRPTSETVMYPYYAKWIRSHRDLPLKLNQWNSVVRWEFKNPQPFLRTREFLWQEGHTAHMTLEGATEEVHQILDLYARIYTDLLAVPVIKGVKSENEKFAGGMFTTTVEGYIPTTGRGIQGATSHCLGQNFSKMFNIVVEDPNAEIGPTGERPKLFVWQNSWGLSTRTIGVAVMVHGDDKGLKLPPAIALVQSVVVPCGITNKTTDQERNEIEGFCSKLADRLNAADIRTEADLRAYTPGYKFSHWEMKGVPLRLEYGPNDAKKNQVTAVRRDTFEKIPVPLNNLEKGVSDLLAKIQTNMYETAKAERDAHVVKVKEWADFVPALNKKNIVMIPWCNTTECEKEIKKNSARQVNGDEPEDEKAPSMGAKSLCIPLEQPSGEDAIIEGTTKCAGCGNLAKVWGLFGRSY
Protein: Polyadenylate-binding protein 1 (AtPabN1) (Poly(A)-binding protein 1) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein I) (PABI) (Q93VI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation.
Subcellular location: Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:23334891}. Cytoplasm {ECO:0000250|UniProtKB:Q7KNF2}. Note=Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. {ECO:0000250|UniProtKB:Q7KNF2}.
Interaction partners:
- Polyadenylate-binding protein 2
- Nuclear poly
- Polyadenylate-binding protein 3
- FIP1[V]-like protein
- SAP domain-containing protein
- Pre-mRNA cleavage factor Im 25 kDa subunit 1
- Histone deacetylase complex subunit SAP18
- Regulator of nonsense transcripts UPF2
- Pre-mRNA cleavage factor Im 25 kDa subunit 2
- RNA-binding protein Y14
Sequence:
MPVHDEQEHEVYGGEIPEEEEGEMDTEEYEEHGGEEGAAAGDEELEPGSSSRDLEDMKKRIKEIEEEAGALREMQAKAEKDMGASQDPSGGVSAAEKEEVDSRSIYVGNVDYACTPEEVQQHFQSCGTVNRVTILTDKFGQPKGFAYVEFVEVEAVQNSLILNESELHGRQIKVSAKRTNVPGMRQFRGRGRPFRPMRGFMPGVPFYPPYAYGRVPRFRRPMRYRPY