wanglab/gogpt-training-data huggingface dataset:
Protein: Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) (Q63932)
Organism: Mus musculus (Mouse)
Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10409742}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000269|PubMed:10409742}.
Interaction partners:
- Serine/threonine-protein kinase B-raf
- Mitogen-activated protein kinase 1
- Dual specificity mitogen-activated protein kinase kinase 1
- Mitogen-activated protein kinase 3
- RAF proto-oncogene serine/threonine-protein kinase
- GTPase KRas
- GTPase HRas
- GTPase NRas
- Serine/threonine-protein kinase A-Raf
- Mitogen-activated protein kinase kinase kinase 1
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV
Protein: Histone H2AX (H2a/x) (Histone H2A.X) (P16104)
Organism: Homo sapiens (Human)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12660252, ECO:0000269|PubMed:12697768, ECO:0000269|PubMed:15613478, ECO:0000269|PubMed:24429368}. Chromosome {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12660252, ECO:0000269|PubMed:15059890, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15613478}.
Interaction partners:
- Mediator of DNA damage checkpoint protein 1
- Breast cancer type 1 susceptibility protein
- TP53-binding protein 1
- Serine-protein kinase ATM
- Histone H4
- Histone H2B type 2-E
- DNA repair protein RAD51 homolog 1
- Histone H3.1
- X-ray repair cross-complementing protein 6
- E3 ubiquitin-protein ligase RNF8
Sequence:
MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQASQEY
Protein: 6-phosphofructo-2-kinase 1 (6PF-2-K 1) (EC 2.7.1.105) (Phosphofructokinase 2 I) (P40433)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Synthesis of fructose 2,6-bisphosphate.
Interaction partners:
- ATP-dependent 6-phosphofructokinase subunit alpha
- Fructose-1,6-bisphosphatase
- ATP-dependent 6-phosphofructokinase subunit beta
- Glucokinase-1
- 6-phosphofructo-2-kinase 2
- Hexokinase-2
- Hexokinase-1
- Fructose-2,6-bisphosphatase
- Putative glucokinase-2
- N-acetylglucosamine kinase
Sequence:
MFKPVDFSETSPVPPDIDLAPTQSPHHVAPSQDSSYDLLSRSSDDKIDAEKGPHDELSKHLPLFQKRPLSDTPISSNWNSPGITEENTPSDSPENSATNLKSLHRLHINDETQLKNAKIPTNDTTDYMPPSDGANEVTRIDLKDIKSPTRHHKRRPTTIDVPGLTKSKTSPDGLISKEDSGSKLVIVMVGLPATGKSFITNKLSRFLNYSLYYCKVFNVGNTRRKFAKEHGLKDQDSKFFEPKNADSTRLRDKWAMDTLDELLDYLLEGSGSVGIFDATNTSRERRKNVLARIRKRSPHLKVLFLESVCSDHALVQKNIRLKLFGPDYKGKDPESSLKDFKSRLANYLKAYEPIEDDENLQYIKMIDVGKKVIAYNIQGFLASQTVYYLLNFNLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFYQNLMQQKKNNENTDGNIYNDFFVWTSMRARTIGTAQYFNEDDYPIKQMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPGIGGESYMDVINRLRPVITELERIEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDEASDSFSKVPQTDLNTTRVKEVGLVYNERRYSVIPTAPPSARSSFASDFLSRKRSNPTSASSSQSELSEQPKNSVSAQTGSNNTTLIGSNFNIKNENGDSRIPLSAPLMATNTSNNILDGGGTSISIHRPRVVPNQNNVNPLLANNNKAASNVPNVKKSAATPRQIFEIDKVDEKLSMLKNKSFLLHGKDYPNNADNNDNEDIRAKTMNRSQSHV
Protein: IFNb2 (B7SVK0)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAVLKWLSICLTLFCQGTAASKPCRWTQFRLGKLNDVSIGLLSDMGGLFPLMCAEENVEQMFPEDLYKNTEGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLNMFQNVIYRQVQNLELCVVGGVWESSGDGWSVTLKTYFNKLNTVLKEKEHSACAWEIVRKEIRENLVQFKKFIDSRVKL
Protein: Serine/threonine-protein phosphatase PP1-alpha (EC 3.1.3.16) (CeGLC-7-alpha) (Glc seven-like phosphatase 1) (Q27497)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Dephosphorylates translation initiation factor eIF2alpha. Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation.
Interaction partners:
- cGMP-dependent protein kinase interacting domain-containing protein
- RNA polymerase II subunit A C-terminal domain phosphatase ssup-72
- pre-mRNA 3' end processing protein pfs-2
- WD_REPEATS_REGION domain-containing protein
- Long arms of the bivalent protein 1
- Cleavage and polyadenylation specificity factor subunit 3
- Probable cleavage and polyadenylation specificity factor subunit 2
- Probable cleavage and polyadenylation specificity factor subunit 1
- Serine/threonine-protein kinase plk-2
- Pre-mRNA polyadenylation factor Fip1 domain-containing protein
Sequence:
MSNDGDLNIDNLITRLLEVRGCRPGKPVTMSEAEIRALCHKSREIFLSQPILLELEAPLKICGDIHGQYNDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKVKYPENFFLLRGNHECASINRIYGFYDECKRRFSIKLWKTFTDCFNCLPIAALIDEKIFCCHGGLSPDLQNMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPDVVAKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYQGMNSGRPAVGGGRPGTTAGKK
Protein: V-type proton ATPase subunit e2 (V-ATPase subunit e2) (Vacuolar H(+)-ATPase subunit e isoform 2) (Vacuolar proton pump subunit e2) (Q9SZ13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18507826}; Multi-pass membrane protein {ECO:0000269|PubMed:18507826}. Golgi apparatus membrane {ECO:0000269|PubMed:18507826}; Multi-pass membrane protein {ECO:0000269|PubMed:18507826}.
Interaction partners:
- V-type proton ATPase subunit H
- V-type proton ATPase subunit c''1
- V-type proton ATPase subunit c''2
- V-type proton ATPase subunit C
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit F
- V-type proton ATPase subunit c3
- V-type proton ATPase subunit D
- V-type proton ATPase subunit a1
- V-type proton ATPase subunit d2
Sequence:
MAFVVTSLIFAVVGIIASICTRICFNKGPSTNLLHLTLVITATVCCWMMWAIVYIAQMNPLIVPILSEVE
Protein: Protein FAM3D (Oncoprotein-induced protein 1) (Protein EF-7) (P97805)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MRVAGLIRVVVFIFTIVTMWVFLRSYTSFSRKTIRLPRWLGITPKDIQTPKSKCGLSKICPNNFFAFKISSGAANVVGPSMCFEDEIIMSPVRNNVGRGLNVALVNGSTGQVMKKDSFDMYSGDPQLLLNFLTEIPDSTLVLVASYDDPGTKMNDKIKTLFSNLGSSYAKQLGFRDSWVFVGAKDLKSKSPYEQFLKNNPETNKYDGWPELLELEGCVPRKVM
Protein: Uncharacterized protein, isoform E (Uncharacterized protein, isoform F) (M9PFQ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYSSKETKSAAKALKKTKKVNKKQQESLSNGNKVKSTPNAKNIQPNNNNKQTNFNNNNSSNNNNNNNNNNNNNNNNNNNNNNNNSSIVSNNNSKNNTLPINVAQKTKQHFEAEKRIQSISMGATTLPGYENVPKMERSNSFLRTKLNKLINHLTGSKENLSRTDSDGDSSRTPYIFTRSRSMIQMRRPNRRSFIEPQLEQLSEETEKSGDLTSPTSPRKTSVADLQASSPVLLRRSELSSSVRTPKRRQSAQPFTSTPLEEVQSPAQRKGSLMSLNQTEPANPQLNFQKRRSNTLIASFKSTFSGFTGSGSGAEKKEKMNPKWSASLQSLQAIDNMVSYANMSFIDYDKFNGYEKQLERQQSLMSLAEQPVTIATQLPLPPSALAHSHSPSPLGDNSRTSVHLGSSMDESVRTVVMRRRRSKTSLEGRSKTSLEGRSSMASLNSAFNLDTAYEHNLDRVHNVYRESLDSRTLDLLNQRTRNSFIHDQAVLFDALNLEDGSVDLRCLFRMTGVWRSRSMRQQQQQRERDAVDGRGKPGKQLKSKSLTHLDGLDSGVVACQQGPPGMATSTASTTATTAGGTGATTGLFATTGAPGSLGRQANVVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVESLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCTEAKNWYDALWRAKTIYQRLKRGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNHLGQSLPNLNMHHSHTVPLRRGMAFSTSTKNPPLRKTRNITSQNSINWHQIPATPTPPSPRSQYQSPGVVCMQKSLPLLLPTNTDEGQGPTQPPPPLQKQLSHQAPLPTTIHNQSSTETDV
Protein: Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Q9IAB2)
Organism: Xenopus laevis (African clawed frog)
Function: May act as a transcriptional corepressor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00440}.
Interaction partners:
Sequence:
MVGIPGPYQFTGDKRVPAMPGSPMEVKIHSRSSPPIMAPLPPVNPGGLRPVGFPPSSHSNGINHSPPTLNGAPSPPQRSSNGPSSSSSSSLANQQLPATCGVRQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAGKQTPSQYLAQHEHILLNTSTSSPADSSELLMEMNGNGKRHSPDRREEERETAPAEPPVKRVCTISPAPRHSPALSLPLVNSTSHFHPTPPPLQHYSLEDIPSSQLYRDHLNKIGEHRDVRDRHHSSGVNGNLNNGYQEELVDHRLTEREWAEEWKHLDHALNCIMEMVEKTRRSMAVLRRCQEVDRDELNYWKRRFNESNEIRKGSEHPSRQHSPSSTDSGASDSVRDFGSRTGAGYVTDEIWRKAEEAVNEVKRQAMSEVQKAVSEAEQKAFEMIASERARMEQTIVDAKRRAAEDAVLVVNEQEESTESCWNCGRKASETCSGCNIARYCGSFCQHKDWEKHHRICGQSMHTQAKPLTPSRSLIPKASDPVLLSPTLERSSSATSRSSTPASVTAVDGL
Protein: Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (EC 2.1.1.355) (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT) (Q8X225)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Histone methyltransferase that specifically trimethylates histone H3 to form H3K9me3. H3K9me3 marks chromatin regions for DNA methylation. Dim-5 recognizes Arg-8 to Gly-12 of the H3 tail with Thr-11 and Gly-12 being the most important specificity determinants, the recognition of whcih is important to distinguish H3K9 from H3K27 and H4K20.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H3
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Heterochromatin protein 1
- Histone-lysine N-methyltransferase set9
- Ubiquitin ligase subunit CulD
- SET-3
- Uncharacterized protein
- DNA
Sequence:
MEKAFRPHFFNHGKPDANPKEKKNCHWCQIRSFATHAQLPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDSDEEADPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGQPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNGLTGLESDAHDPSKISEMTKCLCGTAKCRGYLW
Protein: Erythrocyte-binding antigen 175 (V9XTM1)
Organism: Plasmodium sp. chimpanzee clade C3
Interaction partners:
Sequence:
FLDSRVNDRKNSSSNNGDLNNCREKRRGMKWECKKKNNTSNYVCIPDRRIQLCIVNLSIIKTYTKDSMKNHFIDASKRESELLFKKNNNKYDSKFCEDLKNSFLDYGHLAMGNDMDFGGYSSKAENKIQEVFKEAHGEVSEHEIKNFRKKWWNEFRNELWDAMISQHKNNFLSCKNIPEEELQINQWIKEWHGEFVLERNNISKLPKSKCKDNTLYEACEKECIDPCMKYRDWIIKSKFEWYTLSKEYDTQNVSNKNAENYLIRISNNNNNAKVSLLLKNCDAEYSKYCDCKHTTTLVKSVLNGKDDTSKEVRETVDLNDFSKFGCDEKSVETNRKMWECKKPDILSAKVICVPPRRQELCLGNIDRIYDKNLLMIKEHILAIAIYESRLLKRKYGNKGDDEVCNAIKKSFADIRDIIKGSDYWNDLSNRKLVGKINSNSAYIKRNRENDKHFRDLWWEDIKKNVWHVMRWVFKDNNICKENDIVNVPQFFRWFSEWGDDYCQDKIKMIENLKVACKEKGCEDNNCKNKCSLYKEWILKEKEQYNKQAKQYQEYQKRNNYTMYSEFKSIKPEVYLNKYSKKCSNINFEIEFNEIFPSDYATKCTVCQEVKDVPIPIIRNDAETTQAVVPEE
Protein: Chromosome segregation in meiosis protein 2 (P40465)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Suppressor of HU sensitivity involved in recombination protein 1
- Platinum sensitivity protein 3
- Suppressor of hydroxyurea sensitivity protein 2
- DNA repair protein RAD55
- DNA repair protein RAD57
- DNA repair protein RAD51
- DNA repair protein RAD2
- DNA repair protein RAD4
- ATP-dependent helicase SGS1
- ARS-binding factor 1
Sequence:
MEYEDLELITIWPSPTKNKLCQFIKQNLSKEHVVTQLFFIDATSSFPLSQFQKLVPPTLPENVRIYENIRINTCLDLEELSAITVKLLQILSMNKINAQRGTEDAVTEPLKIILYINGLEVMFRNSQFKSSPQRSHELLRDTLLKLRVMGNDENENASIRTLLEFPKEQLLDYYLKKNNNTRTSSVRSKRRRIKNGDSLAEYIWKYYADSLFE
Protein: Desmin (F1R8W3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004135}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000256|ARBA:ARBA00004216}.
Interaction partners:
- Telethonin
- Vimentin-like
- Fast skeletal muscle myosin light polypeptide 3
Sequence:
MSTKYSASAESASSYRRTFGSGLGSSIFAGHGSSGSSGSSRLTSRVYEVTKSSASPHFSSHRASGSFGGGSVVRSYAGLGEKLDFNLADAINQDFLNTRTNEKAELQHLNDRFASYIEKVRFLEQQNSALTVEIERLRGREPTRIAELYEEEMRELRRQVEALTNQRSRVEIERDNLVDDLQKLKLRLQEEIHQKEEAENNLSAFRADVDAATLARLDLERRIEGLHEEIAFLRKIHEEEIRELQNQMQESQVQIQMDMSKPDLTAALRDIRLQYEAIAAKNISEAEDWYKSKVSDLNQAVNKNNEALREAKQETMQFRHQLQSYTCEIDSLKGTNESLRRQMSEMEERLGREAGGYQDTIARLEAEIAKMKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRISLPVQSFSSLSFRESSPEQHHHQQQQPQRSSEVHSKKTVLIKTIETRDGETRTTSEGMSALSAQRVVSESTQHQQDVM
Protein: Cathelicidin antimicrobial peptide (Q49TU6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKALVRSLLLLAVANLLVRGQTQTETRYEDIITAASNQLLPMEEQAFHPLLNQLEVETLNTEDVDQSEVSVRLSFPLQETLCSKAQGQRGQPCPLKKNGKRMMCSMEVRHPILEIGNTLNTDRSDISCEYMEAEVQKIRTRRGKDSGGPKMGRKDSKGGWRGRPGSGSRPGFGSGIAGASGVNHVGTLPASNSTTHPLDNCKISPQ
Protein: Uncharacterized protein YOR342C (Q12182)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MTILEELNDSSIPQRLDNHIFFGSVHSLTHTDFLVENNIRFFINVDLSTELISHIYHEVRSKFAHEIVIVNIDNDSQIPIESDLVRSFHWHNTSLLQQLIHHLDFLSGINNHGEPLTPPPESHYRNAYVQFDHPSDSVSILDKLLYGNKSEYSRTNIFQVTNEAKFQVFNDLITIFKYSIAQGGNTNSNILVLSENGSTDENLISLLMSTVLKENPTFNVYQALQFVKSIAVIPDTVRDEKILWVTGFINYQELIKKNEMYWGLGSQKGRKLTSFASPISKVERKQRRRDDQNIMRSKLPQQRQNPFCSTERPKRARCD
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FIU4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Thioredoxin
- Ubiquitin-related modifier 1
- Candida glabrata strain CBS138 chromosome E complete sequence
- thioredoxin-dependent peroxiredoxin
- thioredoxin-dependent peroxiredoxin
- Glutathione reductase
- Superoxide dismutase
- Candida glabrata strain CBS138 chromosome A complete sequence
- Candida glabrata strain CBS138 chromosome B complete sequence
- Dihydrolipoyl dehydrogenase
Sequence:
MAAPQVNEKFDVKDIKFQYIDFDQSVSHDACAMPSTTSWSDFLAKNKTVVITGAPAAFSPTCSISHIPGYISKLSDLEAKGVDQVVVVTVDNPFANEAWAKNLGVQNTKHIKFATDAGAELVRHLGYELKVGEGVYWSGRWTVIVKDGVVVYAGNESNPASDVTVSSVEEALKHL
Protein: RNA polymerase I-specific transcription initiation factor RRN11 (Q04712)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor RRN7
- RNA polymerase I-specific transcription initiation factor RRN6
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Bud site selection protein 22
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Acyl carrier protein, mitochondrial
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Cytochrome c oxidase subunit 8, mitochondrial
- RNA polymerase I-specific transcription initiation factor RRN9
Sequence:
MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSLPTPENSAAENNDEEEGQNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQEEETEEGGEHDTGIDKEDSDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHCTKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRFVQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKPFDTENDLLQELIDKISEWVLTPPFMEDAEVWFIYASCHLLKADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTFLKICLDKGGFAVPSRLIENQLKSFESRLYGEAQDIQERDVANVYDSIDNSSVENSFGDVYETNAEFLDTQLMDLSPEDNGLDEMHYSDEDSSE
Protein: Dermokine (Epidermis-specific secreted protein SK30/SK89) (Q6P253)
Organism: Mus musculus (Mouse)
Function: May act as a soluble regulator of keratinocyte differentiation.
Subcellular location: Secreted {ECO:0000269|PubMed:15256262}.
Interaction partners:
- Suprabasin
- Keratinocyte differentiation-associated protein
Sequence:
MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLDYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRDIETSNFDEGYSVSRGTGSRGGSGGSGGSGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW
Protein: Desmoglein-1 (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen) (Q03763)
Organism: Bos taurus (Bovine)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q7TSF1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7TSF1}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q7TSF1}. Cytoplasm {ECO:0000250|UniProtKB:Q02413}. Nucleus {ECO:0000250|UniProtKB:Q02413}.
Interaction partners:
- Corneodesmosin
- Desmocollin-1
- Junction plakoglobin
- Plakophilin-1
- Plakophilin 2.
- Desmoplakin
- Plakophilin-3
- Calpain 14
- Caspase-3
- Keratin, type II cytoskeletal 1
Sequence:
MNWPFFRAAVVLFIFLVVLEVNSDFRIQVRDYNTKNGTIKWHSLRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSLGQDLEKPLELRVRVLDINDNPPVFSMSTFVGEIEENSNANTLVMVLNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDREQYGQYSLAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMELPTQSISIEENSLNSNLLQIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDFEAMNNLQLSLGVRNKAEFHQSIMSQYKLTATAISVTVLNVVEGSVFRPGSKTFVVNSNMGQNYKIGEYVAWDLDANRPSTTVRYVMGRNPTDLLAIDSKTAIITLRNKVTMEQYKILGGKYQGTILSIDDALQRTCTGTIVINLENGGWKTERPNVNGSTTSAYGLTSGGVTTNGYTTGGGVGTVTFAVGTNGYGVGTGVYQPLRDNVHFGPAGIGLLIMGFLVLGLVPFLLMCCDCGGAPGGGAAFEPVPECSDGAIHSWAVEGAQADPGVLANSAVPCIPVTNANVIEYVDNSGVYTNEYGAREMQDLGGGERTTGFELTDGVKMSGGPEICQEYPGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGAGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKDVEPFPDSDPSWPPKSTEPVCPPQGTEPTGGGHPPISPRFGTTTVISENTYPSGPGVQHPTPIPDPLGYGNVTVTESYTSSGTLKPSVHIHDNRHASNVVVTERVVGPISGADLQGMLEMPDLRDGSNVIVTERVIAPSSSLPTTLTIPDPRQSSNVVVTERVIQPTSGIVGNLSMHPELSNTHNVIVTERVVSGSGITGSSSLLGSAGGGSGGGIGLGSLGGGGGLSSSLGGAATIGHLRGSAEHHFSNTLGSASPTTTRSRITKYSTVQYTK
Protein: Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PfCDPK4) (Q8IBS5)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase. Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5. Involved in merosome egress from host hepatocytes, probably together with CDPK5. During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor. Required for cell cycle progression in the male gametocyte. During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre-replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation. For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively. Together with CDPK1, regulates ookinete gliding in the mosquito host midgut (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62345}. Cell membrane {ECO:0000269|PubMed:19307175}; Lipid-anchor {ECO:0000303|PubMed:19307175}.
Interaction partners:
- Putative E3 ubiquitin-protein ligase protein PFF1365c
Sequence:
MGQEVSSVNNTKNEHHKTNKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQAALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGEDTSDLDNAAIEYEVDQILNSIDLDQNGYIEYSEFLTVSIDRKLLLSTERLEKAFKLFDKDGSGKISANELAQLFGLSDVSSECWKTVLKEVDQNNDGEIDFKEFRDMLVKLCNY
Protein: Transcription factor MYB75 (Myb-related protein 75) (AtMYB75) (Production of anthocyanin pigment 1 protein) (Suc-induced anthocyanin accumulation locus 1) (Q9FE25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of phenylpropanoid-derived compounds such as anthocyanins and proanthocyanidin, probably together with GL3 and BHLH2. Regulates the expression of CHS, DFRA, LDOX, and BAN.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TT8
- Transcription factor EGL1
- Homeobox protein knotted-1-like 7
- Transcription factor GLABRA 3
- Protein TRANSPARENT TESTA GLABRA 1
- Dihydroflavonol 4-reductase
- Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase
- Chalcone synthase
- Glutathione S-transferase F12
- Leucoanthocyanidin dioxygenase
Sequence:
MEGSSKGLRKGAWTTEEDSLLRQCINKYGEGKWHQVPVRAGLNRCRKSCRLRWLNYLKPSIKRGKLSSDEVDLLLRLHRLLGNRWSLIAGRLPGRTANDVKNYWNTHLSKKHEPCCKIKMKKRDITPIPTTPALKNNVYKPRPRSFTVNNDCNHLNAPPKVDVNPPCLGLNINNVCDNSIIYNKDKKKDQLVNNLIDGDNMWLEKFLEESQEVDILVPEATTTEKGDTLAFDVDQLWSLFDGETVKFD