wanglab/gogpt-training-data huggingface dataset:
Protein: Putative carbamate hydrolase RutD (EC 3.5.1.-) (Aminohydrolase) (P75895)
Organism: Escherichia coli (strain K12)
Function: Involved in pyrimidine catabolism. May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously (Probable).
Interaction partners:
- 3-aminoacrylate deaminase RutC
- Probable malonic semialdehyde reductase RutE
- Ureidoacrylate amidohydrolase RutB
- FMN reductase RutF
- Pyrimidine monooxygenase RutA
- NADP-dependent 3-hydroxy acid dehydrogenase YdfG
- Putative pyrimidine permease RutG
- HTH-type transcriptional regulator RutR
Sequence:
MKLSLSPPPYADAPVVVLISGLGGSGSYWLPQLAVLEQEYQVVCYDQRGTGNNPDTLAEDYSIAQMAAELHQALVAAGIEHYAVVGHALGALVGMQLALDYPASVTVLISVNGWLRINAHTRRCFQVRERLLYSGGAQAWVEAQPLFLYPADWMAARAPRLEAEDALALAHFQGKNNLLRRLNALKRADFSHHADRIRCPVQIICASDDLLVPTACSSELHAALPDSQKMVMPYGGHACNVTDPETFNALLLNGLASLLHHREAAL
Protein: Sporulation protein RMD1 (Required for meiotic nuclear division protein 1) (Q03441)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for sporulation where it is believed to have a role in meiotic nuclear division.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MVDSNDDQPERHALLHNDIQTSNNSRPSLVQKKYLPTPQDTRKSRASYTGSAMINPTSKQSRTGSGAQRTSRTAQKLKLLPEEPFQRDSERLTDLKNQEVYSQVNRIKDKPARRDAEKLGKAHRHLLPRSTAYCTASSYNMKELVRWLKDCRKLHHTHPKLFDECLYTPFIYNDWRGDKRFEDEDVIRLDDEGGEIIVSDKHPDLFIFEYGVVVMWGFTEREEKAFLNDIEKFEKEKLAEEDIQVEEFNYYVTKSYQPRIYNDFITLRDGSNYMVKLSISHAIAQSVKISLFEELVDNTIEDTQDIPQEIAYSGKVSMSKEDIMKSIGELFILRININLHGSVLDSPEIMWSEPQLEPIYQATRGYLEINQRVSLLNQRLEVISDLLQMLKEQLGHSHEEYLEFIVILLVGVEVLISVINIVVDMLASQH
Protein: 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) (P28223)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28129538}; Multi-pass membrane protein {ECO:0000269|PubMed:36171289}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35363}. Cell projection, axon {ECO:0000250|UniProtKB:P14842}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P14842}. Membrane, caveola {ECO:0000250|UniProtKB:P14842}. Presynapse {ECO:0000250|UniProtKB:P14842}.
Interaction partners:
- Metabotropic glutamate receptor 2
- 5-hydroxytryptamine receptor 2C
- Guanine nucleotide-binding protein G
- 5-hydroxytryptamine receptor 2B
- Sodium-dependent serotonin transporter
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- 5-hydroxytryptamine receptor 1A
- Voltage-dependent L-type calcium channel subunit alpha-1D
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Protein: COBRA-like protein 2 (Q8L8Q7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Cellulose synthase A catalytic subunit 5
- Transmembrane E3 ubiquitin-protein ligase FLY1
- LRR receptor-like serine/threonine-protein kinase FEI 2
- Xylan glycosyltransferase MUCI21
- Beta-galactosidase 6
- UDP-rhamnose/UDP-galactose transporter 2
- Probable galacturonosyltransferase-like 5
- Peroxidase 36
- Fasciclin-like arabinogalactan protein 4
- Pectinesterase inhibitor 6
Sequence:
MNILFSRFSFLLLFLCSWTSFTFTTTEAYDALDPYGNITIKWDIMSWTGDGYVAVVTIFNFQQYRHIEAPGWQLGWSWMKKEVIWSMVGGQATEQGDCSKFKGNIPHCCKKTPAIVDLLPGTPYNQQISNCCRGGVISAWAQDPATAISSFQISVGQSGTTNTTVRAPRNITLKAPGPGYTCGPAKLVKPSRFISADKRRKTQSLLTWNITCTYSQFLARKTPTCCVSLSAFYNETIVPCPTCSCGCQNSSQAGTCVDPKIASVVPALGKNNLEPLLQCTQHMCPIRVHWHVKTSYKEYWRVKVAITNFNYNMNYSQWNLVVQHPNFDNLTKLFSFNYKPLNPYLNINDTAMLWGIKFYNDFLSQAGPVGNVQSELLFQKNPLEFTFEKGWAFPRRIYFNGDNCVMPPPDSYPWLPNASPNIATSPFVILLITFLSVLILM
Protein: Transcriptional regulator (A0A060WAZ1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR001705}.
Interaction partners:
- Protein max
- Protein max
- Protein max
- Uncharacterized protein
- BHLH domain-containing protein
- mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Uncharacterized protein
- Mitogen-activated protein kinase
Sequence:
MPLNSSLASKNYDYDYDSIQPYFYVDNEDEDFYHQQPGQLQPPAPSEDIWKKFELLPTPPLSPSRPSLSSIFPSTADQLEMVTEFLGDDVVNQSFICDADYSQTFLKSIIIQDCMWSGFSATAKLEKVVSERLASLQAARKDSAVGDNAECPTRLNANYLQDPNTSASECIDPSVVFPYPITETPKPSKVAPPTDLALDTPPNSGSSSSSGSDSDDDEEEDDEDEEEIDVVTVEKRQAVKRCDPSTSETRHHSPLVLKRCHVSTHQHNYAAHPSTRHEQPAVKRLRLENSSSRVLKQISSNRKCSSPRTSDTEDYDKRRTHNVLERQRRNELKLSFFALRDEIPDVANNEKAAKVVILKKATECIYSMQTDEQRLVNLKEQLRRKSEHLKQKLAQLQNSCLSSKRH
Protein: Olfactomedin-like protein 3 (Olfactomedin-noelin-tiarin factor 1) (B5MFE9)
Organism: Xenopus laevis (African clawed frog)
Function: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid protease BMP1 and its substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation by BMP1.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MMAGIVACILLVFVTVITAQPQAVFLEYIQGRMGVLEERIAQWHDQSSRFSGELRDFKNQVLKMLENIEKERDSLRNEMENTNVRVNRLEREVDYIETQNPAPPCVEIDEKLSDHHGAKKKKKEKYQKITDCSDTISQVTAMKILKRFGSSAGLWTKDLAGNSDRIYVFDGAGNDTVYMYPRMKEFTLSSPTRKAAKIRLPFPWIGTGHIVYDGNLYYIRQDNEFQVIKFSLANKTIIDSAVLPIEQQVPVYGLSKFNYIDIVADEEGLWVIYATKENEKNICLAKLDPSSLSIEQMWDTPCPIENAESAFVVCGSLYVVYNTKLPSRSRIQCVFDVSGTISSENVPIVYFPKRYGSHSSMKYNPREKQIYAWDDGYQIIYKLNMKHRDELY
Protein: Transcription initiation factor TFIID subunit 9 (Protein enhancer of yellow 1) (TBP-associated factor 9) (Transcription initiation factor TFIID 42 kDa subunit) (TAFII-42) (p42) (Q27272)
Organism: Drosophila melanogaster (Fruit fly)
Function: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Subcellular location: Nucleus.
Interaction partners:
- Transcription-associated protein 1
- Protein will decrease acetylation
- Transcription initiation factor TFIID subunit 13
- SAGA-associated factor 29kDa
- SAGA factor-like TAF6
- Transcriptional adapter 1-2
- Transcription initiation factor TFIID subunit 6
- Transcriptional adapter 2b
- TATA-box-binding protein
- SAGA complex subunit Spt3
Sequence:
MSAEKSDKAKISAQIKHVPKDAQVIMSILKELNVQEYEPRVVNQLLEFTFRYVTCILDDAKVYANHARKKTIDLDDVRLATEVTLDKSFTGPLERHVLAKVADVRNSMPLPPIKPHCGLRLPPDRYCLTGVNYKLRATNQPKKMTKSAVEGRPLKTVVKPVSSANGPKRPHSVVAKQQVVTIPKPVIKFTTTTTTKTVGSSGGSGGGGGQEVKSESTGAGGDLKMEVDSDAAAVGSIAGASGSGAGSASGGGGGGGSSGVGVAVKREREEEEFEFVTN
Protein: 25S rRNA (cytosine-C(5))-methyltransferase NSUN5 (EC 2.1.1.-) (tRNA methyltransferase 4h) (AtTRM4h) (Q8GYE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2268 (m5C2268) in 25S rRNA.
Interaction partners:
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- tRNA
- Ribosomal RNA small subunit methyltransferase, mitochondrial-N
- Putative tRNA
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Putative rRNA 2'-O-methyltransferase fibrillarin 3
- tRNA
- Ribosomal RNA small subunit methyltransferase-N
- Ribosome biogenesis protein BOP1 homolog
- Ribosomal RNA small subunit methyltransferase, chloroplastic
Sequence:
MVARRNKPKAPLVKHRFSGGDSHKPKPPPATKQPFSGVESHKPKTSPATKQKFSGVESHKPKTPPGKQRFSGAESRKPKTPPATKQKFSSLERSALYARREAANILRTVLRGDAERRAVASIKSLVLSPSVRNKRGTFALVCETLKYLTVIKDVLDIANVLNSKWKRQEPLVFIVCYDILFGKDTPSIGDAEKFLMRHKEALLSGLATLLVRKKVDSVDQLLGSKLTGHLKPRYVRVNTLKMDVDSAVQELEKHYTVQKDETVPDLLVLPPGSDLHAHRLVANGRIFLQGKASSMVAAALQPQAGWEVLDACSAPGNKTIHLAALMEGQGKIIACELNEERVKRLEHTIKLSGASNIEVCHGDFLGLNPKDPSFAKIRAILLDPSCSGSGTITDRLDHLLPSHSEDNNMNYDSMRLHKLAVFQKKALAHALSFPKVERVVYSTCSIYQIENEDVVSSVLPLASSLGFKLATPFPQWQRRGLPVFAGSEHLLRMDPVEDKEGFFIALFVRANKLDNPKSSELPDRVCRRRPKERTMQLHPYLCPKMFRAWSGTLHRLKTRFLLSRNGC
Protein: CENP-meta, isoform E (EC 5.6.1.3) (M9PCX3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKVMSLHTELIDSQKGISSRDVEINELREELKAAMDAKATASAEQMTLVTQLKDVEERMANQAEKFTREAANLKGSINELLLKLNSMQETKDMLESGNEELKEQLRNSQNLRNMLDEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVELGRNRIGELTKKCEELCSDLENSDQIRLDLQETKEQLKKTLENNLGWQQKVDEVTRECEKLRFDMQSKEVQNESKVQELISECEELRSTLEASFQSEKESMDRTISSLLEDKRNLEEKLCSANDIVAKLETEIAALRPRKSLDRNPVPRKSITFESEIRKNRRISVHDERRQSYWNDVREFGIMTDPVDNNCNCAELNSKLQDCQRELFIRESQVTALKMELDHHPLKDENAQLTKRVIEEQDKAKVEQKRLKMKLQDLNARINDLTTASAKEPESNQMAQAAKPATVAAQTQTESDLETILEKTNVKYQEAVRMLRYRYHLIQELKEKLRQNENSDTSNITSLSAGQTSALKAQCESQKKEILAIKYKYEAAKRILAIRNDDLDALREKLAKYETTTSDK
Protein: Probable WRKY transcription factor 2 (WRKY DNA-binding protein 2) (Q9FG77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Regulates WOX8 and WOX9 expression and basal cell division patterns during early embryogenesis. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Required to repolarize the zygote from a transient symmetric state.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SI37}.
Interaction partners:
- WRKY transcription factor 1
- VQ motif-containing protein 20
- WUSCHEL-related homeobox 8
- WUSCHEL-related homeobox 9
- Mitogen-activated protein kinase kinase kinase YODA
- WUSCHEL-related homeobox 2
- Protein RKD4
- Mitogen-activated protein kinase 3
- VQ motif-containing protein 9
Sequence:
MAGFDENVAVMGEWVPRSPSPGTLFSSAIGEEKSSKRVLERELSLNHGQVIGLEEDTSSNHNKDSSQSNVFRGGLSERIAARAGFNAPRLNTENIRTNTDFSIDSNLRSPCLTISSPGLSPATLLESPVFLSNPLAQPSPTTGKFPFLPGVNGNALSSEKAKDEFFDDIGASFSFHPVSRSSSSFFQGTTEMMSVDYGNYNNRSSSHQSAEEVKPGSENIESSNLYGIETDNQNGQNKTSDVTTNTSLETVDHQEEEEEQRRGDSMAGGAPAEDGYNWRKYGQKLVKGSEYPRSYYKCTNPNCQVKKKVERSREGHITEIIYKGAHNHLKPPPNRRSGMQVDGTEQVEQQQQQRDSAATWVSCNNTQQQGGSNENNVEEGSTRFEYGNQSGSIQAQTGGQYESGDPVVVVDASSTFSNDEDEDDRGTHGSVSLGYDGGGGGGGGEGDESESKRRKLEAFAAEMSGSTRAIREPRVVVQTTSDVDILDDGYRWRKYGQKVVKGNPNPRSYYKCTAPGCTVRKHVERASHDLKSVITTYEGKHNHDVPAARNSSHGGGGDSGNGNSGGSAAVSHHYHNGHHSEPPRGRFDRQVTTNNQSPFSRPFSFQPHLGPPSGFSFGLGQTGLVNLSMPGLAYGQGKMPGLPHPYMTQPVGMSEAMMQRGMEPKVEPVSDSGQSVYNQIMSRLPQI
Protein: Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (RNA polymerase B subunit 8) (RPB8) (RPB17) (Q19826)
Organism: Caenorhabditis elegans
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
- RNA polymerase Rpb4/RPC9 core domain-containing protein
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit rpb-9
- DNA-directed RNA polymerase II subunit RPB2
- Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Probable DNA-directed RNA polymerase II subunit RPB11
Sequence:
MAGIIFDDMFKVKSVDPDGKKFDRVSRYFCDAESFKMELIIDINSQIYPLKQNDKVRLVLATTLREDGLADEGEYDPKAEYPRIKQYEYVMYGKVYRLEDDDTGTDGGKLAAYASFGGLLMRLKGEAINLHGFEVDMNLYLLMKKTDF
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (P75358)
Organism: Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Enolase
- Glucose-6-phosphate isomerase
- Uridine kinase
- Transketolase
- Chaperone protein DnaK
- L-lactate dehydrogenase
- Pyruvate kinase
Sequence:
MLAKSKTIRVAINGFGRIGRLVFRALLSQKNIEIVAVNDLTHPDTLAHLLKYDSAHGEFKKKVVAKDNTLMIDKKKVLVFSEKDPANLPWAEHNIDIVVESTGRFVSEEGASLHLQAGAKRVIISAPAKQKTIKTVVYNVNHKIINAEDKIISAASCTTNCLAPMVHVLEKNFGILHGTMVTVHAYTADQRLQDAPHSDLRRARAAACNIVPTTTGAAKAIGLVVPEATGKLNGMALRVPVLTGSIVELCVALEKDATVEQINQAMKKAASASFRYCEDEIVSSDIVGSEHGSIFDSKLTNIIEVDGNKLYKVYAWYDNESSYVNQLVRVVNYCAKL
Protein: Vitamin K-dependent protein S (P07225)
Organism: Homo sapiens (Human)
Function: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Subcellular location: Secreted.
Interaction partners:
- Tyrosine-protein kinase Mer
- Tyrosine-protein kinase receptor TYRO3
- Tyrosine-protein kinase receptor UFO
- Vitamin K-dependent gamma-carboxylase
- Coagulation factor V
- Complement C4-B
- Complement C4-A
- Coagulation factor VIII
- Matrix Gla protein
- C4b-binding protein beta chain
Sequence:
MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS
Protein: Phenylpropanoylacetyl-CoA synthase (EC 2.3.1.218) (Diketide CoA synthase) (C0SVZ5)
Organism: Curcuma longa (Turmeric) (Curcuma domestica)
Function: Catalyzes the formation of feruloyldiketide-CoA by condensing feruloyl-CoA and malonyl-CoA in the curcuminoid biosynthesis. Has no activity with cinnamoyl-CoA.
Interaction partners:
Sequence:
MEANGYRITHSADGPATILAIGTANPTNVVDQNAYPDFYFRVTNSEYLQELKAKFRRICEKAAIRKRHLYLTEEILRENPSLLAPMAPSFDARQAIVVEAVPKLAKEAAEKAIKEWGRPKSDITHLVFCSASGIDMPGSDLQLLKLLGLPPSVNRVMLYNVGCHAGGTALRVAKDLAENNRGARVLAVCSEVTVLSYRGPHPAHIESLFVQALFGDGAAALVVGSDPVDGVERPIFEIASASQVMLPESAEAVGGHLREIGLTFHLKSQLPSIIASNIEQSLTTACSPLGLSDWNQLFWAVHPGGRAILDQVEARLGLEKDRLAATRHVLSEYGNMQSATVLFILDEMRNRSAAEGHATTGEGLDWGVLLGFGPGLSIETVVLHSCRLN
Protein: Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] (P00750)
Organism: Homo sapiens (Human)
Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Plasminogen activator inhibitor 1
- Plasminogen
- Annexin A2
- Plasminogen activator inhibitor 2
- Protein S100-A10
- Prolow-density lipoprotein receptor-related protein 1
- Immunoglobulin lambda variable 10-54.
- Alpha-2-antiplasmin
- Immunoglobulin lambda-like polypeptide 5
- T-cell surface glycoprotein CD4
Sequence:
MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
Protein: ELMO domain-containing protein E (Q54WH5)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- SH3 domain-containing protein
Sequence:
MKLQIYNPNGEEFQYDFKSDIPFSFHIKNLYENLVVHNNGLKKILQSFPYCEANRSYDEIYSHYSLQEATSGNWMSNSTDSTFIKGSPDNTLFFKLKPLTHYLTPIEKLIGTTTSSSSSSSSPSSSSSSSSSSSSSSPSSPSLIGLILSLQTHLALLMYENIYGNKNNSKDTNNSGTINNNNNNNNNSGGSNIKLSSTPSSSFLTFPTSTSNLLLSSDVIKKILNIVFLAPSPQSLQLLVFLVSNSPSNDDLLSQISNTHSNSQLHGFSIGGGGGGSGNNSSITSIGGGDSKKIENKDNSGSAVVGSQSNSPQSSSFVKSQQIQQQQQYQKPNNSSPPPTTTTTTTTTTTTSGSQVKLSVGGNSGSFNNTTESSPSLFTLVDTAIKSVSTEHSSNFYLHILNNPAYNEVIETHFEMVCLILSLINNMYRLSPNPINYFNRLHNDSILKYIMEFAKKNQKIYQNTQYIVLRNYLMKELHMQRLHPINVDKVLSHQILLSDLWGSALSSYPFGGINSEHWLLLGFRSSNPMEDFKNTGVLALRNLSYFSKQHLQPFQSLLLTQTKREKDDNDNNNNKVIDKPIITNKFNIETLDDDNDNNNNQELNNNNNNNNNNNYNIKTKPRSNSRSYPLATVAISLTYTLSNIFRIGRINDSPIDSSIWDIAFSGSNWFDEIFVTTFNLFESLWHSEAHSYSDFPQVISHTREIIEKVCSKSPINLQDFKDKLTTLLEKKDEISSLDVNTVETLARYHQLQPSHINKRHIHKFFGERVNVDKLPNSNNPTDNIITTNTNTTTTTTTSTNNDCESTILQDHIESDKNNDDNNNNNEIIDDCESNSSFLVSSNTKEFSGKNLIKFFGEKTDQKEQYSTQPSNVKSYKLKNFFGDQPVVINKNGGGGGGGGGGGVDNELNQGGETVNKNKNDLIDDSDDENDNDEVNNNNNSNRINQDINHKLYGNSPISERNHRLHVFFGEWFDTEQVEYNEKIRSSSSTPDTSSPPLNSQPESARLHKLNKFFGERVNIPISKPKVIGEGGGGGIFPIDDIDVTDGSTNNHHIGGGGGGGSSDNLLSRSPEETRSDFKAQKVLGERLDIKKEKESINFASQPSNVREYKLHKLFGEMVPAHKQKSPKLQGGSGPWKKGNVSKSDSQAVVAPLNTIKFNNGNTNMNPLLQSCPTPINSPTSLSSDHLLDDVLDLNQTNNNIDNENDDINEAIIPPSLSPTLLGVNNHGEEEEEEEEEEEGYNHTQDNHAQDNHAQDNLLLLDDDDDTKSEPIPSTNTLLDSDIIPNNTTTTTTTTTTTTTTTTNTTGQKRISILSTDTNRPGSSNYGESSLSNGSRFDGIPESTTHNANGDDDHQINLHSSSPQPLPKFVNTDDEDNNNNNNNKKQDDDEDDEDDDDKEEIRKKRENKTNHRLHVFFGERFDVENIHFFTRVSSSPGSYDAHLNNPHLSVSPQPETVRSYKLKKFFGKNPEDNVTLSSSYDSSTSPLLSQLNHHHHHNHHQSASNLINNINNNNNNNNNNNSNNNSNNQNNLNSSNNSNNSSISNNSGKNNTNNNNNNNTNNNNDNSPSTSPSSSFKKHQYQYVSAEDPEGDVSKTNEIRKLRRDFKTQRILGERLNIKKESTVVAFQDQPSTIKVDKLISLFGEKVGFSLKRKESQRDLQHQASSSNLKFSLASSSK
Protein: Uncharacterized protein YmdA (P75917)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YnjH
- Uncharacterized protein YecR
- Uncharacterized protein YiiF
- O-acetyl-ADP-ribose deacetylase
Sequence:
MFRPFLNSLMLGSLFFPFIAIAGSTVQGGVIHFYGQIVEPACDVSTQSSPVEMNCPQNGSIPGKTYSSKALMSGNVKNAQIASVKVQYLDKQKKLAVMNIEYN
Protein: FMRF-Like Peptide (A3QM96)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- G protein-coupled receptor EGL-6 isoform b
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 19
- Soluble guanylate cyclase gcy-33
- Receptor-type guanylate cyclase gcy-9
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 5
- FMRFamide-like neuropeptides 9
- FMRFamide-like neuropeptide 18
- FMRFamide-like neuropeptides 3
Sequence:
MLSKLVLTTCLLLTISGSSQAASMEEIQSEKFCEKFPTLHMCRLKEELTGSLVELQYLLQDGINNQQQAGAQEVQKRKSAFVRFGKRSAPEEEAMEMEKRKSAFVRFGRSFGMEPQITEKRKSQYIRFGK
Protein: CRC-B (Cryptocephal, isoform B) (GH11210p) (Q9NIR3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSTYIFMQAYECLLDQKATLNCIDYDSNSFQPNINVITQAIVPANKVQFGASSDAASLPSAADYQLNDGPSLILQQLTPPQSPPQFDAYKQAGDAQPKPVLVKAEQKVQCYTPDVTHAASATPFNFTNWVGGSEIARENQLVDDIVNMRAKELELSTNWQQLNEDCESQASSSLDSRSTGSGVCSSIADADEDWVPELISSSSSPAPTTIEQSASQPKKRTRTYGRGVEDRKIRKKEQNKNAATRYRQKKKLEMENVLGEEHVLSKENEQLRRTLQERHNEMRYLRQLIREFYHERKR
Protein: Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C) (O95843)
Organism: Homo sapiens (Human)
Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Interaction partners:
- Retinal guanylyl cyclase 1
- Retinal guanylyl cyclase 2
- Guanylyl cyclase-activating protein 2
- Guanylyl cyclase-activating protein 1
- Cyclic nucleotide-gated channel beta-1
- Mitochondrial glutamate carrier 2
Sequence:
MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLRVICNGKQPDMETDSSKSPDKAGLGKVKMK