wanglab/gogpt-training-data huggingface dataset:
Protein: AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) (Q3UHJ0)
Organism: Mus musculus (Mouse)
Function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:F1MH24}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1MH24}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P0C1X8}. Presynapse {ECO:0000250|UniProtKB:P0C1X8}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. {ECO:0000250|UniProtKB:P0C1X8}.
Interaction partners:
- AP-2 complex subunit mu
- Epidermal growth factor receptor substrate 15
- AP-2 complex subunit beta
- RalBP1-associated Eps domain-containing protein 1
- AP-2 complex subunit sigma
- Epidermal growth factor receptor substrate 15-like 1
- Clathrin coat assembly protein AP180
- AP-2 complex subunit alpha-1
- Phosphatidylinositol-binding clathrin assembly protein
- Adaptin ear-binding coat-associated protein 1
Sequence:
MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPIPAKLPEPVKASEAAVKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPLPQAAGPSNQPGLLPSVSQPKAQATPSQPLQSSQPKQPQAPPTPQQTPATQTQGLPTQAQATPQHQQQHLLKQQQQQQQQPQQPTAPPQPAGTFYQQQQQQQQQQAQTQQFQAVHPAAQQPVTAQFPVGSQGGAQQQLMQNFYHQQQQQQQQQQQLMAQQAALQQKTAVVVPQSQAQPATAPQAAAAQEPGQIQAPVRQQPKVQTTPPPTIQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVSNASEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKLPEKLGGSAESLIPGFQPTQGDAFTTPSFSAGTAEKRKGGQAVDSGIPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIDKADVAVESLIPGLEPPVAQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTAGLLEEFAPIALSAPTHKAAEDSNLISGFGVAEGSEKVAEDEFDPIPVLITKNTQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
Protein: Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) (P62632)
Organism: Rattus norvegicus (Rat)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q05639}.
Interaction partners:
- Elongation factor 1-gamma
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran, testis-specific isoform
- GTP-binding nuclear protein Ran
- Heat shock transcription factor 1
- 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Elongation factor 1-alpha 1
- Tyrosine-protein phosphatase non-receptor type 6
- Eukaryotic translation elongation factor 1 beta 2
- Ac2-067
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKADPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK
Protein: dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21-C6) (Q9QY93)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19220460}. Note=Not detected in mitochondrion and nucleus. {ECO:0000269|PubMed:19220460}.
Interaction partners:
- Deoxycytidylate deaminase
- Nucleoside diphosphate kinase A
- Deoxycytidine kinase
- Ribonucleoside-diphosphate reductase subunit M2
- Ribonucleoside-diphosphate reductase large subunit
- 5'
- Adenylate kinase 9
- Nucleoside diphosphate kinase B
- Ribonucleoside-diphosphate reductase subunit M2 B
- Nucleoside diphosphate kinase 6
Sequence:
MSTAGDGERGTVGQEDSAAARPFRFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKSDTEPGPQAWPPKERAALQEELSDVLIYLVALAARCHVDLPQAVISKMDTNRQRYPVHLSRGSACKYTDLPRGTISENQAVGAGDPASELRDQAST
Protein: HCLS1-binding protein 3 (F6PCK0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- PX domain-containing protein.
- PX domain-containing protein kinase-like protein
- Sorting nexin family member 21
Sequence:
MSDGRITSRPLQNEATGIDLHVPLYQEIRGSVITGHVEYQIVVVTCLSSFKSAIHKTGDVLQFVVSKKYSEIEQLYYSLKTKYPSIHLPPMPRKALFVSETDLCNRRVAFDELVKFLSKHPLLANCPELLEFLGAKTTAVEVKTINKPDFIEKEVDDGLDFFESGDPLQKPSEDVELLDPLGSEWLKKDVKPKDVCPVGKCVPKPKSETLFEEEDDTELFSPAKKGHVMLFDNTPLRSIDSSPFSNTSNGIKMTESKVDEDIEELLSVEMDLHKHLSVSKTVRCRPDTAMNPMKPKVKSKPVASERTSNLTQATDLQLSGTEVMNQMDILQYIQQNDLPASEDLDLFKS
Protein: Kappa-type opioid receptor (K-OR-1) (KOR-1) (P34975)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8240267}; Multi-pass membrane protein {ECO:0000269|PubMed:8240267}.
Interaction partners:
- Pro-opiomelanocortin
- Proenkephalin-B
- Proenkephalin-A
- Mu-type opioid receptor
- Prepronociceptin
Sequence:
MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
Protein: 2-hydroxychromene-2-carboxylate isomerase (HCCA isomerase) (EC 5.99.1.4) (Q51948)
Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
Function: Involved in the naphthalene catabolic pathway. Catalyzes the reversible glutathione-dependent isomerization of 2-hydroxychromene-2-carboxylate (HCCA) to trans-O-hydroxybenzylidenepyruvate (THBPA).
Interaction partners:
Sequence:
MIVDFYFDFLSPFSYLANQRLSKLAQDYGLTIRYNAIDLARVKIAIGNVGPSNRDLKVKLDYLKVDLQRWAQLYGIPLVFPANYNSRRMNIGFYYSGAEAQAAAYVNVVFNAVWGEGIAPDLESLPALVSEKLGWDRSAFEHFLSSNAATERYDEQTHAAIERKVFGVPTMFLGDEMWWGNDRLFMLESAMGRLCRQNADLSS
Protein: SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) (Q99MS0)
Organism: Rattus norvegicus (Rat)
Function: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol (By similarity). Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol. {ECO:0000250}.
Interaction partners:
Sequence:
MSGRVGDLSPKQEEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDKIISWQPPEVIQQYLSGGRCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRDCELLLQECTQQTAKLGKKIETITMIYDCEGLGLKHLWKPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKQYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSEGSDVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHMVPEDGTLTCSEPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKAAEEKLNQQGAVTPK
Protein: Lysine exporter LysO (Lys outward permease) (P75826)
Organism: Escherichia coli (strain K12)
Function: Mediates export of lysine.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Aquaporin Z
- Uncharacterized protein YbjD
- Uncharacterized membrane protein YahN
- Arginine exporter protein ArgO
Sequence:
MFSGLLIILVPLIVGYLIPLRQQAALKVINQLLSWMVYLILFFMGISLAFLDNLASNLLAILHYSAVSITVILLCNIAALMWLERGLPWRNHHQQEKLPSRIAMALESLKLCGVVVIGFAIGLSGLAFLQHATEASEYTLILLLFLVGIQLRNNGMTLKQIVLNRRGMIVAVVVVVSSLIGGLINAFILDLPINTALAMASGFGWYSLSGILLTESFGPVIGSAAFFNDLARELIAIMLIPGLIRRSRSTALGLCGATSMDFTLPVLQRTGGLDMVPAAIVHGFILSLLVPILIAFFSA
Protein: Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (A0A060YDW5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ig-like domain-containing protein
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Endothelin-3
- Guanine nucleotide-binding protein G
- Neuropeptide Y
- Uncharacterized protein
- Uncharacterized protein
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MAMIPDITCLSGPRVNLNISFTFGPTPCNQTVLRTAPYSPEATALFATAITLMMILTIVGNILVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELQGYWAFRSLWCEIYLALDVLFCTSSIAHLCAISLDRYLSISRPVSYGAQRTPARIKAAIVVVWLLSAAISFPPLLSLDKSEGGVEVCELNNERWYILYSTIGSFFAPCLIMIGVYIKIYQIAKQHTRCPPGEKPNLNTTPGNAQLQHNRGEGGKADGQSKNAVPSKSLPVSSPSSPPPQSETQAKTPTGPQIEPQPQTQPSSPTSRQRNTTNDDSFSSGSEAEAEMSGKRKGWEGTGQPGKAQVTPMSRRKAMVNREKRFTFVLAVVIGVFVICWFPFFFSYSLQAICPETCTLPDPLFKFFFWIGYCNSCLNPVIYTIFNQDFRKAFKKILCRDTKGTNF
Protein: MaoC-like domain-containing protein (Q19058)
Organism: Caenorhabditis elegans
Interaction partners:
- SCP2 domain-containing protein
- Non-specific lipid-transfer protein-like 2
- Acyl-coenzyme A oxidase acox-1.1
- Acyl-coenzyme A oxidase acox-3
- Acyl-coenzyme A oxidase acox-1.3
- Acyl-coenzyme A oxidase acox-1.4
- Acyl-coenzyme A oxidase acox-1.2
- Acyl-coenzyme A oxidase
- Probable acyl-coenzyme A oxidase acox-1.5
- Bifunctional glyoxylate cycle protein
Sequence:
MDKKTACAHVAEPCEFSYSTRDAIIYALGVGARAKEDLCYVYENHEDFKVLPSYIVAPGFQAHTLMDWPGVEFDLQRVLHGEQYIEVYQPLSAEGKLKSEARVVDILDKGSGALILGNVTTYDENGKKIAMQQFSTFQTGSGNFGGDRTSPHEIKAATVPDRAPDAVIEQKTTVDQAALYRLGSGDMNPLHVDPEFAKMSGFKTPILHGLCSLGFATRHVIAAWAGNDSDKFKAIKVRFSSPVLPGQTLVTETWKNGKRIIFQMKVKETGKIVISNAFIDLHEASELPTVPIDLASKL
Protein: Vinculin (A5JYX3)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPANGNSHAYFNIDEVRSKNVLKQITQLINEVTNITETFPLKPGQTTEGLVATLDAAVANFLQTGSFAISKCPIANSDPRAIDLLHEALGAVQDTGQVMIQTGRDFVRDSTSTNKRAIATNSGRNLLTAVAKFLILADSIDVKVIVDKVDEVRETAHQMIEADTKIKVDDLYNLLISQIEELDITVRRRAIDLVKPNQRDDLLAARSALRQTAPLLYTSTRTFVRHPEHEEARRNRDYTADEMHSALNALESVLNGQQPKVTFSEYGRIGDLINEIDTFQNRIEIDPAHYRRGTDRPDLEGHCERIVSGSASIADAESTRENRKQKIVAECNNLRQALQELLTEYEKSTGRRDDNDDIPLGIAEVHKRTKDLRRHLRRAIVDHISDAFLDTRTPLILLIEAAKEGHEENTRYRSKMFQEHANEIVSVARLSCQLSSDVESVSVIQHTAAQLEKLAPQVAQAAILLCHQPTSKTAQENMETYKNAWFDKVRLLTTALDNITTLDDFLAVSEAHIVEDCERGIKGITANASTPDENAANCETVDCAAGSIRGRALRVCDVVDAEMDFLQNSEYTETVKQAVRILKTQRVDQFAERASALANRQEAHGLTWDPKTKEEEMNEFINACTLVHDAVKDIRHALLMNRSMNDVDSDVEYEADGVGAANADANRTISEQENQQNLMRRLPEEEKKKIQAQIDIFKVTQTRFEREVAKWDETGNDIISLANNMCKIMMSMTEFTRGCGPLKTTMDVIRAAQEISLNGSKLNALARQIGEESADSQTKKDLLAYLSQITLYCQQLNICSKVKADVTQVGNELVVSALDSAMSLIQTARNLLTAVVQTVKAAYIASTKFRRPNANSVRVEWRMAPPKKQPLIRPQKNNAIIRVCRRASERRPLQPAKVLAEFTRNEIETGRDSDDEELDRRHQQRINGRL
Protein: Large ribosomal subunit protein eL31y (60S ribosomal protein L31-2) (Q9STR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL38z/eL38y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL27x
- Large ribosomal subunit protein uL23z
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS19y
- Large ribosomal subunit protein eL43y
Sequence:
MSEKKGRKEEVVTREYTINLHRRLHSCTFKKKAPKAIKEIRKFAEKEMGTKDVRVDVKLNKQIWSKGIRGPPRRIRVRVARKRNDDEDAKEEFFSLVTVAEIPAEGLSGLGTKIIEEED
Protein: Ferredoxin-1, chloroplastic (AtFd1) (O04090)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Ferredoxin--NADP reductase, leaf isozyme 1, chloroplastic
- Assimilatory sulfite reductase
- Ferredoxin--NADP reductase, leaf isozyme 2, chloroplastic
- Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic
- Photosystem I reaction center subunit IV A, chloroplastic
- Protein NAR1
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Photosystem I reaction center subunit IV B, chloroplastic
- Iron-sulfur cluster assembly protein 1
- Photosystem I reaction center subunit psaK, chloroplastic
Sequence:
MASTALSSAIVSTSFLRRQQTPISLRSLPFANTQSLFGLKSSTARGGRVTAMATYKVKFITPEGEQEVECEEDVYVLDAAEEAGLDLPYSCRAGSCSSCAGKVVSGSIDQSDQSFLDDEQMSEGYVLTCVAYPTSDVVIETHKEEAIM
Protein: Mediator of RNA polymerase II transcription subunit 14 (Protein STRUWWELPETER) (AtSWP) (Q9SR02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in defining the duration of cell proliferation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 10a
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 10b
- Mediator of RNA polymerase II transcription subunit 6
- Cyclin-dependent kinase E-1
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 22a
- Mediator of RNA polymerase II transcription subunit 7b
Sequence:
MAELGQQTVDFSALVGRAAEESFLSFKELVDKSKSTELSDTEKKVSLLKYVAKTQQRMLRLNALAKWCKQVPLINYFQDLGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPKCLDDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKISKGTVTLSVDGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPANQEGEADSVSLRTPGMKLFYWSDSDKNSGPFIKIEPGSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRNTRICRTPSDVILQALLDEPGIEGDNMVDSKERVEPEVLRVRAYGSSFFTLGINIRTGRFLLQSSKSILTSSILEEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVYEHGFGINKVPKSLLDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLLETQMDGSGKPQSFNDPSNILRAKKIDIGQIRILEDDLNLITSDVVKFVSSFSDAEGINQASGHRQPGLVDEALTEMSGSQLSFSSVVDGVFGLQKVTSALMSIDGHGLVPKNLSAVTGHGKAPMLTSYHSDSLYNRQGPLQSSSYNMLSSPPGKGSAMKKIAISNSDQELSLILSPSLSTGNGVSESGSRLVTESSLSPLPLSQTADLATSSAGPLLRKDQKPRKRSASDLLRLIPSLQVVEGVASPNKRRKTSELVQSELVKSWSPASQTLSTAVSTSTKTIGCSYGNLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDAFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKTTPWGSGVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGIKPDEKTEECSANSTMKGSTGGKGSGEPVDRWRAFKIEAVGLTSLWFSFGSGVLARFVVEWESGKDGCTMHVSPDQLWPHTKFLEDFINGAEVESLLDCIRLTAGPLHALAAATRPARASTATGMPVVPATASSRQSNQIQQTQGIIAPSTLAAPNATGQSASATSGNTVASSAPSPLGGGFHGVAMLAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGATNPNSGNPTVNGVNRVNFSPSSARAAMNRVASVASGSLVVSSGLPVRRTPGTAVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQAQQNGSSAAAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQSQQAGEIAPAQRPRIELCLENHSGTDLDNNCAAKSNIHYDRPHNTVDFALTVVLDPVHIPHINAAGGAAWLPYCVSVRLRYTFGENPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLREGGNNNNNTHQKEFTI
Protein: Transcription repressor OFP1 (Ovate family protein 1) (AtOFP1) (Q9LZW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors. Controls the subcellular localization of the homeodomain protein BLH1. Plays a role in the regulation of cell elongation by controlling the expression of GA20OX1, a gene that encodes a key enzyme in gibberellin biosynthesis. May play a role in double-stranded DNA repair through the DNA non-homologous end joining (NHEJ) pathway along with KU70 and KU80 protein complex. Possesses DNA-binding activity towards double-stranded and single-stranded DNA in vitro.
Subcellular location: Nucleus {ECO:0000269|PubMed:15781858, ECO:0000269|PubMed:17461792, ECO:0000269|PubMed:21457372}.
Interaction partners:
- Homeobox protein knotted-1-like 7
- BEL1-like homeodomain protein 3
- BEL1-like homeodomain protein 1
- Transcription repressor OFP11
- Transcription repressor OFP15
- Homeobox protein knotted-1-like 3
- Transcription repressor OFP16
- Transcription repressor OFP18
- Transcription repressor OFP14
- Transcription repressor OFP12
Sequence:
MGNNYRFKLSELIPNAWFYKLRDMSKSKKKNLQSQPNSTTSKKKHHAVPTPTSTTPLSPRPPRRPSHSSKAPPSHPPRKSSGNRLRHRATVDSKSSTTSGDSTTTETGSFSPDFRSDQVLLPDESLTGSWHSPCSSKLSKTATFTPPPELELRPIITKTAATARKTAVNSPAGVRLRMRSPRISVSSSARRSGSSARRSRAVVKASVDPKRDFKESMEEMIAENKIRATKDLEELLACYLCLNSDEYHAIIINVFKQIWLDLNLPPPHSK
Protein: Mitochondrial potassium channel (MITOK) (Coiled-coil domain-containing protein 51) (Q3URS9)
Organism: Mus musculus (Mouse)
Function: Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:31435016}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial potassium channel ATP-binding subunit
Sequence:
MTGCSPVFAMQHVVGVPRILVRRTFLGTDVTMTRTLCSPGPREKRPEAAALGLFHRLPELGRTLSHTVRHQAASTAKAWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREGLEAQQTKLKEVRDRLDRVSREDNQYLELATLEHRMLQEEKRLRIAYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPASLQEAIREQASSYSLQQKDLQDLMMDLRGLVHAEQGQGSGSPTGSSTRGKDIDGLSATMKEQLRHSRQVYSCLEGLREQLDGLEKTCSQMAGVLQLAQAPAHPGTVGPVDGALPSSLLEHGSVILALSEMEQRLEAQANRNTVSSTLVTCVTFLATLPLLYMLFKTS
Protein: Transformer 2 alpha (A0A8I5ZXL0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
KNLLKIFSQVKGSIKTSQLSQHNRNERQRAKNSLSRSRRHSHRRYTRSRSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRYRRRSPSPYYSRYRSRSRSRSYSPSM
Protein: LemA protein (A0A0H2UQI3)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MTWIILGVIALIVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRRNDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMKASDALTRQVSGIFAVAESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMFGFKAADFLQTPEEEKSVPKVDFSGLGD
Protein: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (Q62865)
Organism: Rattus norvegicus (Rat)
Function: Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9Z0X4}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q14432}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Adenosine kinase
- GTP:AMP phosphotransferase AK3, mitochondrial
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
- Adenine phosphoribosyltransferase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Deoxycytidine kinase
- Inosine triphosphate pyrophosphatase
Sequence:
MAVRGEAAQDWAKPGLRGPSPAPVARGDHRCRGGSPSSPRGSGCCWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELESSQEAAAEEEEEEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVALTSALRTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQLLPQCSGPAPPRERFGSQSSARTKEEIPGWKRRRRSSSVVAGEMSGCGGKSHRRTSLPCIPREQLMGHSEWDHKRGSRGSQSGTSVTVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPVLMTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLDKISPVPSPSSSPPQGSPTSSPVSGIASVQFPESPEVTTKRGPGSHRALTYTQSAPDLSPQIPPSPVICSSCGRPYSQGNPADGPSERSGPAMQKPNRTDDTSQVTSDYETNNNSDSSDILQNDEEAECQREPLRKASACGTYTPQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKAYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDLHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQAPDQAPLQHSSEQIQAIKEEEEEKGKPRAEETLAPQPDL