Protein: BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 (AtBAK1) (BRI1-associated receptor kinase 1) (EC 2.7.10.1) (EC 2.7.11.1) (Protein ELONGATED) (Somatic embryogenesis receptor kinase 3) (AtSERK3) (Somatic embryogenesis receptor-like kinase 3) (Q94F62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors. Involved in brassinosteroid (BR) signal transduction. Phosphorylates BRI1. May be involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1-BAK1 heterodimers. Interaction with MSBP1 stimulates the endocytosis of BAK1 and suppresses brassinosteroid signaling. Acts in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) via its interactions with FLS2 and EFR, and the phosphorylation of BIK1. Involved in programmed cell death (PCD) control. Positively regulates the BR-dependent plant growth pathway and negatively regulates the BR-independent cell-death pathway. Phosphorylates BIR2 and thus promotes interaction with BIR2. This interaction prevents interaction with FLS2 in the absence of pathogen-associated molecular patterns (PAMP). Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. Required for PSK promotion of seedling growth and protoplast expansion. CNGC17 and AHAs form a functional cation-translocating unit that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes. Required during SCOOP small peptides (e.g. RGF1, SCOOP10 and SCOOP12) perception and signaling; associates with MIK2 as a coreceptor upon MIK2 perception of SCOOP peptides, and relays the signaling through the activation of receptor-like cytosolic kinases (RLCKs) BIK1 and PBL1 (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12150928, ECO:0000269|PubMed:12150929, ECO:0000269|PubMed:15548744, ECO:0000269|PubMed:26071421}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:15548744}; Single-pass type I membrane protein {ECO:0000255}. Note=Endocytosis enhanced upon interaction with MSBP1. {ECO:0000269|PubMed:19532123}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase FLS2
- Protein BRASSINOSTEROID INSENSITIVE 1
- LRR receptor-like serine/threonine-protein kinase EFR
- Probably inactive leucine-rich repeat receptor-like protein kinase At5g48380
- BRI1 kinase inhibitor 1
- Serine/threonine-protein kinase BIK1
- Receptor-like protein 44
- Inactive LRR receptor-like serine/threonine-protein kinase BIR2
- Leucine-rich repeat receptor-like protein kinase PEPR1
- Elongation factor Tu, chloroplastic
Sequence:
MERRLMIPCFFWLILVLDLVLRVSGNAEGDALSALKNSLADPNKVLQSWDATLVTPCTWFHVTCNSDNSVTRVDLGNANLSGQLVMQLGQLPNLQYLELYSNNITGTIPEQLGNLTELVSLDLYLNNLSGPIPSTLGRLKKLRFLRLNNNSLSGEIPRSLTAVLTLQVLDLSNNPLTGDIPVNGSFSLFTPISFANTKLTPLPASPPPPISPTPPSPAGSNRITGAIAGGVAAGAALLFAVPAIALAWWRRKKPQDHFFDVPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLEGDGLAERWEEWQKEEMFRQDFNYPTHHPAVSGWIIGDSTSQIENEYPSGPR