wanglab/gogpt-training-data huggingface dataset:
Protein: Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Protein Ndr1) (Q62433)
Organism: Mus musculus (Mouse)
Function: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath.
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane (By similarity). {ECO:0000250}.
Interaction partners:
- N-myc proto-oncogene protein
Sequence:
MSRELHDVDLAEVKPLVEKGESITGLLQEFDVQEQDIETLHGSLHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAPSFPVGYMYPSMDQLAEMLPGVLHQFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLVLMNVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEIHNNVEVVHTYRQHILNDMNPSNLHLFISAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDNSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLEGTRSRSHTSEGPRSRSHTSEGSRSRSHTSEDARLNITPNSGATGNNAGPKSMEVSC
Protein: Ribitol 5-phosphate transferase FKRP (EC 2.7.8.-) (Fukutin-related protein) (EC 2.4.2.-) (Ribitol-5-phosphate transferase) (Q8CG64)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12471058, ECO:0000269|PubMed:17554798, ECO:0000269|PubMed:26923585}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:19900540}. Cell membrane, sarcolemma {ECO:0000269|PubMed:17452335}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H9S5}. Cytoplasm {ECO:0000269|PubMed:29416295}. Note=The N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted (PubMed:19900540). Localization at the cell membrane may require the presence of dystroglycan (PubMed:17452335). At the Golgi apparatus localizes to the middle-to-trans-cisternae (PubMed:12471058, PubMed:17554798). Detected in rough endoplasmic reticulum in myocytes (By similarity). {ECO:0000250|UniProtKB:Q9H9S5, ECO:0000269|PubMed:12471058, ECO:0000269|PubMed:17452335, ECO:0000269|PubMed:17554798, ECO:0000269|PubMed:19900540}.
Interaction partners:
- Ribitol-5-phosphate transferase FKTN
- Ribitol-5-phosphate xylosyltransferase 1
- Protein O-mannosyl-transferase 2
- Protein O-mannosyl-transferase 1
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- Dystroglycan 1
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
- Protein O-mannose kinase
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Sequence:
MRLTRCWAALAAAIILNLLVFFYVSWLQHQPRNSRARGPRRTSAIGPRVTVLIREFEAFDNAVPELVDSFLQQDPAQPVVVAADTLPYPPLALPRIPNVRLALLQPALDRPAAASRPETYVATEFVALVPDGARAESPGHLERMVEALRGSSARLVAAPVATANPARCLALNVSLREWTARYDPAPSAPRCDALDGDAVLLMRSRDLFNLSVPLARPLATSLFLQTALRGWAVQLLDLTFAAARQPPLATAHARWKAEREGRSRRAALLRSLGIRLVSWEGGRLEWFGCSKESARCFGTVAGDTPAYLYEGRWTPPCCLRALRETARYVVGVLEAAGVRYWLEGGSLLGAARHGDIIPWDYDVDLGIYLEDVGNCEQLRGAEAGSVVDERGFVWEKAVEGDFFRVQYSENNHLHVDLWPFYPRNGVMTKDTWLDHRQDVEFPEHFLQPLVPLPFAGFMAQAPNNYRRFLELKFGPGVIENPEYPNPALLSLTGG
Protein: Acetone carboxylase alpha subunit (EC 6.4.1.6) (Q8RM03)
Organism: Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide.
Interaction partners:
- Acetone carboxylase beta subunit
- Acetone carboxylase gamma subunit
- Hydantoinase/oxoprolinase
- Acetone carboxylase gamma subunit
- Hydantoinase/oxoprolinase
Sequence:
MNVTVDQSTLAGATRGIVRGGETLKEHRDRLMAATKATGRYAGLKTLELREREPILYNKLFSRLRAGVVDARETAKKIAASPIVEQEGELCFTLYNAAGDSLLTSTGIIIHVGTMGAAIKYMIENNWEANPGVHDKDIFCNNDSLIGNVHPCDIHTIVPIFWEGELIGWVGGVTHVIDTGAVGPGSMATGQVQRFGDGYSITCRKVGANDTLFRDWLHESQRMVRTTRYWMLDERTRIAGCHMIRKLVEEVVAEEGIEAYWKFAYEAVEHGRLGLQARIKAMTIPGTYRQVGFVDVPYAHEDVRVPSDFAKLDTIMHAPCEMTIRRDGTWRLDFEGSSRWGWHTYNAHQVSFTSGIWVMMTQTLIPSEMINDGAAYGTEFRLPKGTWMNPDDRRVAFSYSWHFLVSAWTALWRGLSRSYFGRGYLEEVNAGNANTSNWLQGGGFNQYDEIHAVNSFECAANGTGATAVQDGLSHAAAIWNPEGDMGDMEIWELAEPLVYLGRQIKASSGGSGKYRGGCGFESLRMVWNAKDWTMFFMGNGHISSDWGLMGGYPAASGYRFAAHKTNLKELIASGAEIPLGGDTDPENPTWDAMLPDAQIKRDKQAITTEEMFSDYDLYLNYMRGGPGFGDPLDREPQAVADDINGGYVLERFAGEVYGVVVRKGADGQYGVDEAGTAAARAQIRKDRLAKSVPVSEWMKGEREKILAKDAGTQVRQMFAASFKLGPRFEKDFRTFWSLPDSWTLPEEEIGVPTYGSRYSMDISELPDVHTVQFVEE
Protein: Elongin-C (Q7KYI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
DAMYVKLISSDGHEFVVKREHALTSGTIRAMLSGPGQFAENEANEVHFREIPSHVLQKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (C1BFL3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MVLKAVCVLTGTGDVTGTVFFEQEGEDAPVKLTGEIAGLAPGEHGFHVHAFGDNTNGCMSAGPHFNPHNKTHGGPNDDVRHIGDLGNVTAGADNVAKINIQDKILTLTGPLSIIGRTMVIHEKADDLGKGGNEESLKTGNAGGRQACGVIGITQ
Protein: Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 (E9PY03)
Organism: Mus musculus (Mouse)
Interaction partners:
- Superoxide dismutase, mitochondrial
- Small ribosomal subunit protein mS29
- Endoribonuclease YbeY
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL24m
Sequence:
MLRLAVLRHSHTSAAAGTMAGVPTVSFSELRSLVASGRARLFDVRSPEEAAAGTIPGALNIPVSELEIALNMDPAAFQTLYCAEKPKLEDKNLIFFCQMGRRGLQATQLAQGLGYTGARNYAGAYKEWLEKQG
Protein: Heat stress transcription factor A-7a (AtHsfA7a) (AtHsf-09) (Q9SV12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Heat shock 70 kDa protein 4
- Dehydration-responsive element-binding protein 2A
- Multiprotein-bridging factor 1c
- Heat shock protein 21, chloroplastic
- Heat shock protein 90-1
- Chaperone protein ClpB1
- Protein HEAT-STRESS-ASSOCIATED 32
Sequence:
MMNPFLPEGCDPPPPPQPMEGLHENAPPPFLTKTFEMVDDPNTDHIVSWNRGGTSFVVWDLHSFSTILLPRHFKHSNFSSFIRQLNTYGFRKIEAERWEFANEEFLLGQRQLLKNIKRRNPFTPSSSPSHDACNELRREKQVLMMEIVSLRQQQQTTKSYIKAMEQRIEGTERKQRQMMSFLARAMQSPSFLHQLLKQRDKKIKELEDNESAKRKRGSSSMSELEVLALEMQGHGKQRNMLEEEDHQLVVERELDDGFWEELLSDESLASTS
Protein: Isatin hydrolase (EC 3.5.2.20) (Isatin amidohydrolase) (Isatin hydrolase isoform b) (IH-b) (A0NLY7)
Organism: Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata)
Function: Involved in the degradation of the plant hormone indole-3-acetic acid (IAA). Catalyzes the hydrolysis of the cyclic amide bond (lactam) of isatin (1H-indole-2,3-dione) to yield isatinate (2-(2-aminophenyl)-2-oxoacetate).
Interaction partners:
Sequence:
MSAQSALSGLGAKLLSGEVEVVDCTGVLGPNTPILQLPPDFAKNTPKVEIHKISEYDSDGPFFAWNWMVLGEHSGTHFDAPHHWITGKDYSDGFTDTLDVQRLIAPVNVIDCSKESAADPDFLLTADLIKAWEAEHGEIGAGEWVVMRTDWDKRAGDEAAFLNADETGPHSPGPTPDAIEYLLSKKIVGWGSQCIGTDAGQAGGMEPPFPAHNLLHRDNCFGLASLANLDKLPAKGAILIAAPLKIERGTGSPIRALALVPKA
Protein: Protein MIS12 homolog (Protein MINICHROMOSOME INSTABILITY 12) (AtMIS12) (Protein MIS12-LIKE) (Q2V0Z5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Constitutive component of kinetochores that is essential for proper cell division during mitotic cell cycle (Probable). May play a role in the modulation of centromere during meiosis.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16331414, ECO:0000269|PubMed:21695238}. Note=Localizes at centromeric regions throughout the mitotic cell cycle. Co-localizes with CENH3 during the cell cycle, from interphase to anaphase (PubMed:16331414). Localized at centromeres in meiotic cells (PubMed:21695238). {ECO:0000269|PubMed:16331414, ECO:0000269|PubMed:21695238}.
Interaction partners:
Sequence:
MEGSKSEAVFDSMNLNPQIFINEAINSVEDYVDQAFDFYARDASKSLKIKGSDKQKSQALSNGIARVRGLLLSVIDNRLKLWESYSLRFCFAVPDGFVLPKSEESSSVHQDGLYDLELDAELDSLRDKLNVVGKRSVELDSELQALERSSVSRERSLRLVNEALELYDESSMDEIFKEMTKMASELRASVERLKTRRMKASESAKVKRLKNHGKEFSAMTFDGKLEDLEKFQAELRKM
Protein: Putative protein MSS51 homolog, mitochondrial (Zinc finger MYND domain-containing protein 17) (Q4VC12)
Organism: Homo sapiens (Human)
Interaction partners:
- Cytochrome c oxidase assembly protein COX14
- Cytochrome c oxidase assembly factor 1 homolog
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase assembly factor 3 homolog, mitochondrial
Sequence:
MAPRSRRRRHKKPPSSVAPIIMAPTTIVTPVPLTPSKPGPSIDTLGFFSLDDNVPGLSQLILQKLNMKSYEEYKLVVDGGTPVSGFGFRCPQEMFQRMEDTFRFCAHCRALPSGLSDSKVLRHCKRCRNVYYCGPECQKSDWPAHRRVCQELRLVAVDRLMEWLLVTGDFVLPSGPWPWPPEAVQDWDSWFSMKGLHLDATLDAVLVSHAVTTLWASVGRPRPDPDVLQGSLKRLLTDVLSRPLTLGLGLRALGIDVRRTGGSTVHVVGASHVETFLTRPGDYDELGYMFPGHLGLRVVMVGVDVATGFSQSTSTSPLEPGTIQLSAHRGLYHDFWEEQVETGQTHHPDLVAAFHPGFHSSPDLMEAWLPTLLLLRDYKIPTLITVYSHQELVSSLQILVELDTHITAFGSNPFMSLKPEQVYSSPNKQPVYCSAYYIMFLGSSCQLDNRQLEEKVDGGI
Protein: Scribbler, isoform G (E1JGL0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESMRRNEANTSHHPNKVALNSSNVATESNIKNNKLLANLSAAGAATATTATTGTATTTTATTANQALNFNNKTKATANATAASANNRHNNNNNSSAIKKHTNTKQLAGKSPACNSSSSSLSSSSSSNSSESKDTNFEYEDEWNIGGIPELLDDLDADIEKSAHSSGGGNQATALNAKQANSSSTSSSSSSKGGASSSSSSAAATGSSSSHKSHKTTLHSNLSATSPTTIKFTRQPVAIGGANSSSSSSAAAAPSGGSANVVAKGSSSSSSSTSSSSSGKHHHHHHHHSNSSSSGSSSKGYKSALVAQLNSPSPLNSNSKSLSGSGSGSGNTNGAAGAGAGSTLSSSTFAGFSKGGSLVSSSAGAAAALAAGSGQQGSKFSAGGMSSQTGSGSGGNNTSNSNNSSSGSGGSGSGSSTGNTASGSGNNNSTSAGGPPSSQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQQNGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSGSSSSGGGSQNNASGHASGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASAAGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMSAVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSSAGGVGGSGGGANAPGPPGKESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMISATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPRFCDSPTEELDSRTPKGRGKRGRSAGLTPDLSNFTETRSSIYFSHAQVHSKLRNGATKGRGATRSASGNAAANSNSSSSGNGGGATPSTSPTAFLPPRPEKRKSKDEAPSPLNGDASDGASVGGIGGAGGVNMVNASGIPISASGGGLATQPQSLLNPVTGLNVQISTKKCKTASPCAISPVLLECPEQDCSKKYKHANGLRYHQSHAHGAGGGASSMDEDSMQAPEDPATPPSPGVASGTGSGASVASSAVPATAPSAGQGTVAVSPNTPLANSSNPVTNGNVAPSAPATGSVTIAAPNTTPSVVETQAPLTGPPPVTPPAPTPICAVATPGAEQSVSSVLPLGNLPLTAGPNSATQQQQPPTQQQQPQLLVPGGSAASLQQQQQQQQPVAGGSITAGISGQALSQHQQQLMGGLPAMLSDQQQQALLQQGALKAGVLRFGPPDGNPLQQQPGQASVNPQTQQSPPRPPSHVQDQQTPSAYAQQAGLKTSPGFGSVGVGAASSKQKKNRKSPGPSDFEGRVSREDVQSPAYSDISDDSTPVAEQEMLDKSVGQAVTAKHIELMGKKPTEVGVGVPPPPAPNMYVPGMYQFYPAQQQSAPPPQQQQQQPQYMVQTEPGKPPGLPPALTQAQQQQQLQPGAPPPTSQPPSHLLGPPGQQSVAAHLADYSGKNKDPPLDLMTKPQPQPGQPPSQQQQSGQLSGQENNGKDVGPPTSQPGSQPPPVNLSAVAGPPPGSLPPGLGGLSALGAAGLGGPGPGKGMPHFYPFNFIPPAYPYNVDPNFGSVSIVASEEAAKLSGHPGLPPSSQAQQLSGISIKEERLKESPSPHDQPKHMPSQQQMIASKLIKQEPMTKQEIKQEPNSNPGQQHPPPQQQPAPQPQQQQPPPPQPQQPHALHPKDLQALGAYPAIYQRHSINLAVQQAREEELRRYYMFTGRQNSAAAAAAAAAQNAASGGLPPHPGMMHKDEPGMGSAAQQQQQQQQQQMQIAQQQQQAIQQHHQHLQQQHQAQQQQQQQQHQQQQQQQQQQQQQQQQQQQQQKLKQSQAASAGANNKATNLTKDSPKQKGGDDDQPLKVKQEGQKPTMETQGPPPPPTSQYFLHPSYISPTPFGFDPNHPMYRNVLMSAAGPYNTAPYHLPIPRPYHAPEDLSRNTGTKALDALHHAASQYYTTHKIHELSERALKSPTSGSGPVKVSVSSPSIGPPQPGGPTSSGPGSGPVSGVLGPGSGSNQQPGSAPGSAGGVPLNLQPPPGGMGPSPGSKPDLSGPKGHGGVTPGSSLDGHKQSMPGGPPPNGPSGNGAVGGVGGAAGNGAAGGGGAGAADSRSPPPQRHVHTHHHTHVGLGYPMYPAPYGAAVLASQQAAAVAVINPFPPGPSK
Protein: Baseplate wedge protein gp6 (Gene product 6) (gp6) (P19060)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Baseplate protein that is located next to the tail tube (inner baseplate). Involved in the tail assembly. The gp25-(gp6)2-gp7 module is involved in sheath contraction.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04102, ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:2403438, ECO:0000269|PubMed:27193680}. Note=12 copies of gp6 form a continuous ring that makes up most of the inner baseplate. {ECO:0000255|HAMAP-Rule:MF_04102, ECO:0000269|PubMed:27193680}.
Interaction partners:
Sequence:
MANTPVNYQLTRTANAIPEIFVGGTFAEIKQNLIEWLNGQNEFLDYDFEGSRLNVLCDLLAYNTLYIQQFGNAAVYESFMRTANLRSSVVQAAQDNGYLPTSKSAAQTEIMLTCTDALNRNYITIPRGTRFLAYAKDTSVNPYNFVSREDVIAIRDKNNQYFPRLKLAQGRIVRTEIIYDKLTPIIIYDKNIDRNQVKLYVDGAEWINWTRKSMVHAGSTSTIYYMRETIDGNTEFYFGEGEISVNASEGALTANYIGGLKPTQNSTIVIEYISTNGADANGAVGFSYADTLTNITVININENPNDDPDFVGADGGGDPEDIERIRELGTIKRETQQRCVTATDYDTFVSERFGSIIQAVQTFTDSTKPGYAFIAAKPKSGLYLTTVQREDIKNYLKDYNLAPITPSIISPNYLFIKTNLKVTYALNKLQESEQWLEGQIIDKIDRYYTEDVEIFNSSFAKSKMLTYVDDADHSVIGSSATIQMVREVQNFYKTPEAGIKYNNQIKDRSMESNTFSFNSGRKVVNPDTGLEEDVLYDVRIVSTDRDSKGIGKVIIGPFASGDVTENENIQPYTGNDFNKLANSDGRDKYYVIGEINYPADVIYWNIAKINLTSEKFEVQTIELYSDPTDDVIFTRDGSLIVFENDLRPQYLTIDLEPISQ
Protein: Protein NRT1/ PTR FAMILY 5.2 (AtNPF5.2) (Peptide transporter PTR3-A) (AtPTR3) (Q9FNL7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Peptide transporter involved in stress tolerance in seeds during germination and in defense against virulent bacterial pathogens.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MTVEEVGDDYTKDGTVDLQGNPVRRSIRGRWKACSFVVVYEVFERMAYYGISSNLFIYMTTKLHQGTVKSSNNVTNWVGTSWLTPILGAYVGDALLGRYITFVISCAIYFSGMMVLTLSVTIPGIKPPECSTTNVENCEKASVLQLAVFFGALYTLAIGTGGTKPNISTIGADQFDVFDPKEKTQKLSFFNWWMFSIFFGTLFANTVLVYVQDNVGWTLGYGLPTLGLAISITIFLLGTPFYRHKLPTGSPFTKMARVIVASFRKANAPMTHDITSFHELPSLEYERKGAFPIHPTPSLRFLDRASLKTGTNHKWNLCTTTEVEETKQMLRMLPVLFITFVPSMMLAQINTLFVKQGTTLDRKVTGSFSIPPASLSGFVTLSMLISIVLYDRVFVKITRKFTGNPRGITLLQRMGIGLIFHILIMIVASVTERYRLKVAADHGLIHQTGVKLPLTIFALLPQFVLMGMADSFLEVAKLEFFYDQAPESMKSLGTSYSTTSLAIGNFMSSFLLSTVSEITKKRGRGWILNNLNESRLDYYYLFFAVLNLVNFVLFLVVVKFYVYRAEVTDSVDVKEVEMKETE
Protein: Aminoaldehyde dehydrogenase 2, peroxisomal (MdAMADH2) (EC 1.2.1.-) (Aminobutyraldehyde dehydrogenase AMADH2) (EC 1.2.1.19) (A0A0E3T3B5)
Organism: Malus domestica (Apple) (Pyrus malus)
Function: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes. Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively.
Subcellular location: Peroxisome {ECO:0000269|PubMed:26296314}.
Interaction partners:
Sequence:
MAIQIPSRQLFIDGEWREPVLKKRIPIINPATEQIIGDIPAATAEDVEIAVEAARKALARNKGRDWALAPGAVRAKYLRAIAAKIAERKSEIAKLEAIDCGKPLDEAAWDIDDVSGCFEYYADLAEGLDAQQKTPISLPMEQFKSHVLKEPIGVVGLITPWNYPLLMATWKVAPALAAGCAAILKPSELASVTCLELADVCREVGLPPGVLNILTGLGHEAGAPLASHPHVDKIAFTGSTMTGSKIMTAAAQLVKPVSLELGGKSPIVVFDDVDIDKAAEWTAFGIFWTNGQICSATSRLIIHENIAAKFLDRLVQWCKNIKIADPLEEGCRLGPVVSGGQYEKILKFIATAKSEGARVLSGGARPEHLKKGFFIEPTIITDVTTSMQIWREEVFGPVLCVKTFSSEDEALELANDSHYGLGAAVISKDLERCERVSKALQAGIVWINCSQPCFCQAPWGGNKRSGFGRELGKWGLDNYLTVKQVTEYVSDDPWGWYKSPSKL
Protein: Uncharacterized protein (Q57UW5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPAPHNSPRLLECRHVFGVCESVKGGIQYLDDNNVVWVSGKNLIILDTQLGTQQMVSCTPGCKKVTAMALSNNRRFLAVAESSKQPSIVIYGCDSNTTPRLKRKKILQLPDLGSSEYVSLSFSHDGRNLASLGGQPEWNLVYWSVERGKVIASCAVLDDSEAATADHDLLKQCSICPNDSSIVCVSGSGIVRFFSQQGSQLRRTPGGVRESVTNYLAHVWIPSENWLILSTENGDLVLMENNEVKYALPLSPSDGIAITALVACGKGFICGGDLGLISIYERVDNKEMYRKVRTFKFNNDSNIMGPPGDAIPVILSFTLSPPPAEEYVSFLTSTKQLYSLNLPNADFFKNEDGVFEPIGQPFHSAPVIGVDICVQRPLAVTAGRDRCVFVWNFITGVVEFRKRFTSDICSVALHPSGTHLLVGLADGLHMMNLYYNDVRHLKNIGIRSCMECRFSNGGNFFAAAHATTVYVYFTHTCELIGHLRGHSGKVKSIYFVPPDDTRIITVGMDGAVFEFSLCDFHKVNDNTLKEMTYNCAVADLGTVWTAGNDRKLRQFDRTKLSQVAVHDLHNASIFSMAISSRLKLLFTGCEDGTVRVFNTYLGERLSLNDNDNDVNGIMSELHHAHAGVVSRLVLSFDDGLIISTGEDGAVIFWDVVAPYRGPQKEVEYSSELFVARKDMEASTKTVVELTAEATELKERMRQQQIIRDRVHEEQLSRLEREFAEKRAERVARFEALKEEKNEQAIRFTEYMAEMEDKDKASLLRTKEDYAAKILFLRRRSDRLQQLISEKQHEHDKNIVRIREQARQKPVEDREIQQRTIKELDDRYQQLLAEKEEDEKRTDTFCAMMEEATDVEVIKRKEGNEKRRKEQSHELFALQGVNDSLLSAENIARAELEATKAEVRERMRQQAALESQIEAAKRDIEALTQEFRDRGETIAEKERRVLDLKKKNQELEKFKFVLEYKIKELKSQIDPRDEEIRQTKSRLAEMGREADKYTRSNDHLVLQIRNLRQKKAGQSRELEKLAVSMRSFGEFQSRLWTELCDLHDETNPRKLKESAKQLFDKYTSGKAIGTLKALASRSAADEVREYNRERDHLERNLAGLRNKVNKNAENNRSDKYRITAENVILIKEINDLRKEARLLAGKAGVWRSAGQSSVSACEEDVIREIASQRAELARLNEIAKKLEEDIQTRSAQVPLSTKKEE
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A0A8I5ZQN2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MVPVARLLLLLLAFFLYACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAVAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSFDHYAT
Protein: Proteasome regulatory ATPase subunit 2 (EC 3.6.4.8) (Q386D8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory ATPase subunit 6
- Ubiquitin carboxyl-terminal hydrolase
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Proteasome subunit alpha type
- 26S proteasome regulatory non-ATPase subunit
- Proteasome subunit alpha type
- Probable 26S proteasome regulatory subunit rpn-6.2
- Proteasome subunit alpha type
Sequence:
MGQAGGKEQKRQQEKWEPPVATDIGKKKKRHGPDAAAKLPKIYPSRACLLKQLRLERCKDYLLLEDELLTMITSQWDAQENLEEGAMSHYEAELSKVDALRGMPLEVGTLEEVIDDTHAIVSTAGSEYYVAMLSFVDKEKLELGCSVLLHDRYHNVVGLLESNTDPLVSVMKVDKAPQETYADIGGLEDQIQEIKEAVEFPLSHPELFDEVGVKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGEGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSGGAKEVQRTMLELLTQLDGFDSCNDVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDLSEFIHAKDEMSGADIKAICTEAGLLALRDRRMKVCQSDFVKGKENVQYRKDKGRFSKFYL
Protein: Large ribosomal subunit protein uL2 C-terminal domain-containing protein (A9VAD3)
Organism: Monosiga brevicollis (Choanoflagellate)
Interaction partners:
- Large ribosomal subunit protein eL24-related N-terminal domain-containing protein
- Small ribosomal subunit protein uS17
- 40S ribosomal protein S28
- 60S ribosomal protein L38
- 40S ribosomal protein S9
- 60S ribosomal protein L32
- Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein
- KOW domain-containing protein
- 40S ribosomal protein S3
- 60S ribosomal protein L6
Sequence:
MNALLAAAGLQAEPADPTVLKAKQAKQAKQAKQVDTSAQTAKDQSTFTDTTRIHKKRSASLSNRHHGKSSGSSQPSKTKRKGVQADSISPDAATNEALSADSAIAAAPSVCAQSSSSTPVPTKASEHERQSSHSKPVQHAKLLNDRGQRPKRGSHASNQRSTETAPLTAADSVSNLSSDSSATSHQRTGLSEVASATGATSQSAATMSTSARSSEGSRGDDEESEGDSYAGEPAFKTAKRHGQSHQSHQRSLQPSGQAKLSPSRPTSGPEDSARGSPTSPASTVDSQLTDRTREFNRIAALRHRQRAKMRRLELDQRLLEASRHQQQLKMEMEELSKKHHSLLELCFTLYGPGGIRQSWLTTSRFGHVPVVGAHHARFGGPLDAHPGLMHHPGMGMGLGMGMGMGVPVNMGMNMPMHHHLNQAHSSHHLADMRPANTMQMGMGGLNPSMAHHAAVGGLNPSLSQTSVHQPNMFPMAMFGYPGAANPGNNNAAATGSTFKFNPFTGEPMTGTGTEDPFAANPSQQQQQQQQQLLMAATDHLRSTLQGKDGARALNNALATPVPKMGRVIRGQRKGAGSIFTSHTKHRKGAARLRPVDYAERHGFIKGMVREIIHDPGRGAPLARVVFRDPYRYRLQKETFVCAEGMHTGQFIYCGKKAELSVGNVKPVGEMPEGTIVCNLEEKPGDRGVIARASGNYVTVIAHNSDTGKSRVRLPSGSKKTIPSTCRAMVGLIAGGGRIDKPLLKAGRAYYKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTCKRDTPAGRKVGLIAARRTGRLRGGQSSGKDE