wanglab/gogpt-training-data huggingface dataset:
Protein: DNA helicase MCM9 (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) (Q2KHI9)
Organism: Mus musculus (Mouse)
Function: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex at double-stranded DNA breaks to generate ssDNA by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (By similarity). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin (By similarity). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:23401855}. Chromosome {ECO:0000269|PubMed:23401855}. Note=Colocalizes to nuclear foci with RPA1 following DNA damage (PubMed:23401855). Localizes to double-stranded DNA breaks (By similarity). Recruited to chromatin by MSH2 (By similarity). {ECO:0000250|UniProtKB:Q9NXL9, ECO:0000269|PubMed:23401855}.
Interaction partners:
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM7
- DNA helicase MCM8
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM6
- DNA replication factor Cdt1
- Cell division control protein 6 homolog
- Mini-chromosome maintenance complex-binding protein
- Origin recognition complex subunit 1
Sequence:
MNSEQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAILQSLPETEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADFEQYYTFSRPSSCPSLASCDSSKFSCLSDLSSSPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDVRCEVEIVLKANYVQVNNEQSSGMVMDEDTRKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQVLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQGGALLGGVNALHTSFPENPRAQYQRQCELILEKLELQGLLQEELRRLERLQNESVHQCQSHSLEEEVAPGSCRNDPRDKPRLRTSTQQEQSCSWSSTERSGADSPPGPGLNRPTSCNNSAENRDGRGDGLDWLDPTSSPEIAPESTIVSPNVKTTEKNVNLKISNNKSQGKEKHGPQQRSKLLEAGHLPSSGAMNAPLRSHGVKRTKASQAVVVSEAGRGDEEDSVPRRLPKLLKEGSQNVCRSTTRVRPLPPTVPLSLSIPSPGSGKRSGTPKRKRRKSAQVEEPEPEGMETPTVKLAKFTFKQKTKLTHSPEGQGPIPPSASEIAVDSSKIPQQRTRREAAVPVVAPGKSTSTSGDRCSDQLHGKTKELSRQPPDSNPPREEREQGPKRRVIQPKPELGNQAGHSHLACEKDRKEGVSCGNKSSKVHAGTIARLASFSFTSPSESKSESLPPERKDSRDSRDSRDSRDRCHSPPATTAPVLGQQRQTFQLQQPTERANLSTLSLFTLSELDDEALDFDWEEEMRKKP
Protein: Peptide methionine sulfoxide reductase B9 (AtMSRB9) (EC 1.8.4.12) (Peptide-methionine (R)-S-oxide reductase) (Q84JT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Peptide methionine sulfoxide reductase A2
- Peptide methionine sulfoxide reductase A4, chloroplastic
- Peptide methionine sulfoxide reductase A3
- FAD-dependent oxidoreductase domain-containing protein 1
- Peptide methionine sulfoxide reductase A1
- Cotton fiber protein
- Uncharacterized protein
- NAD
- Berberine bridge enzyme-like 10
- Peptide methionine sulfoxide reductase A5
Sequence:
MPTSATAVAPSTGSVQKKDQDWRAILSPEQFRVLREKGTENRGKGEYTKLFDDGIYSCAGCATPLYKSTTKFDSGCGWPSFFDAIPGAIKQTPEAGGRRMEITCAACDGHLGHVVKGEGFPTATDERHCVNSVSLKFSEISSQ
Protein: Hepatoma-derived growth factor (HDGF) (P51859)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P51858}. Cytoplasm {ECO:0000250|UniProtKB:P51858}. Secreted, extracellular exosome {ECO:0000269|PubMed:21087088}. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity). {ECO:0000250|UniProtKB:P51858}.
Interaction partners:
- Pleiotrophin
- Nucleolin
Sequence:
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL
Protein: Putative GTP-binding protein, SAR1B (Secretion-associated RAS super family 1) (T12M4.12 protein) (O80489)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
- SEC12-like protein 2
- SEC12-like protein 1
- Protein transport protein SEC31 homolog A
- SEC12-like protein
- Protein transport protein SEC24 A
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC13 homolog A
- Protein transport protein SEC23 B
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC23 D
Sequence:
MFLFDWFYGILASLGLCKKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKINFKAFDLGGHQIARRVWKDCYAKVDAVVYLVDAYDRDRFVESKRELDALLSDEALANVPCLILGNKIDIPYASSEDELRYYLGLTNFTTGKGIVNLEDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIK
Protein: Cytochrome c biogenesis Fc (Q8HCM9)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
- Cytochrome c biogenesis B
- Cytochrome c biogenesis Fn
- Maturase-related protein
- Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 6
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome c oxidase subunit 2
- NADH-ubiquinone oxidoreductase chain 3
- Large ribosomal subunit protein uL5m
Sequence:
MVQLQNFFFFITFMVVLCGTAAPVLLKWFVSRDVSTGASFFNGTIIPILISLFSFLVYLHSRKFIRSMDRAKSGVLVKASRPILLPDKIGRSSSARNALFCFVPVLHFFIIESMGDLSYLESFCGLLCLQFFCTLFSLPRDRSAKRERALRSKGQTLWPKGNEQQNDKMRCPGHPHIERRVEGFGPVAFPAPPLSSGACLGPPEIGLEALALPTSRLLMAVGHDYYKKVKMNLSISHGGVCIFMLGVLLSNTNKIQFTQRLPLGSELHMGKERCCLRGLDHLHGPTFHSICGNLMIYKPSPTSERFMFEHDESLRADLLPINFPASYENGKLEDFLHRWMKNHEHKNFRFSMFPERRYFFSIRETRSTTEVAIHTNLFTDLYALIGTGSSRTGGWYTTIMKLPFLFSIWIGFLLASLGGSRSLLRQLQKDKLHWN
Protein: Argonaute protein wago-4 (Worm-specific argonaute protein 4) (O62275)
Organism: Caenorhabditis elegans
Function: Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Also interacts with the mRNA targets of 22G-RNAs. Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:29769721, ECO:0000269|PubMed:29791857, ECO:0000269|PubMed:30728462}. Cytoplasmic granule {ECO:0000269|PubMed:29769721}. Cytoplasm {ECO:0000269|PubMed:29791857}. Note=Co-localizes with znfx-1 in P-granules in germline blastomeres until the 100-cell stage (PubMed:29769721). During oocyte maturation, co-localizes with znfx-1 in liquid-like condensates in the cytoplasm called Z granules (PubMed:29769721). Localizes to cytoplasmic P-granules in germline blastomeres. {ECO:0000269|PubMed:29769721}.
Interaction partners:
- NFX1-type zinc finger-containing protein 1 homolog
- RNA-directed RNA polymerase
- Protein simr-1
- DRBM domain-containing protein
- Uncharacterized protein
- MUTator
- Endoribonuclease dcr-1
- PAP-associated domain-containing protein
- Argonaute protein hrde-1
Sequence:
MPALPPVYTPSGAPSSVHAPPAVPPVPVPTQPLRSEYQTSNDACIKRLEELNIAPAAKLYPTPTEPGKCGVEAEIQTNVFGIEMHQDSLFYQYSVNITTELKNGKEVTFTKKGKDDFVVTERHDKCCAILFRALGDYEEFFKTSDSCLIYDGQSILFSNVDLFQGFREGAVKTKYMQLDGGEMDHKDLKSLPCIKLEVFPTKNPAVKFTREAVARRATDSNLDSVSLAYQQILELALTQPCLRNTARYVVFDHGKMFFIDPLGEGFEKCDVVDVGDGKQVVPGLKKTINFIEGPYGRGRSNPSVVIDGMKVAFHKNQPILDKLKEITTQPVEHGLKGLEKDRCAAVIKGLDCYSTYGGRERHHKIEGIHHEGARNARFELNDGGSCTVAQYFEDVYNITLRYPDTNLIVSKERGNINFYPMELLKISSHQRVQIPQLTSAQSQKTTKESAVLPDVRQRLILTGKNAAQISSDNEVLGKMGVSVCEDPLMVKGRSIPAVKLANAEIGANPINVKDNKWRANRFTRPATAPNVWAMYVVGTASTRITLDTLKKFADEFAAMCKSKGVNMPAPADISLIHMDAIESRLYDATKANCTFVFIITDDSITTLHQRYKMIEKDTKMIVQDMKLSKALSVINAGKRLTLENVINKTNVKLGGSNYVFVDAKKQLDSHLIIGVGISAPPAGTKYAMENKGVLNPNVIGYAYNAQHNQEFSGDFVLNSASQDTLAPIEDIVMHSLNEYQKFHDGGLPRRVIVYRTGTSEGNHGSIMAYEIPLARAAMRDFSPDIQLVYIVVSKDHSFRFFKPDLASLASRPQATSSTASRHSAMPAAPKAWDLNIAPGILVDSIVTNPACKQFFLNSHITLQGTAKTPLYTVLADDAKVSMTALEDITYKLCHLHQIVGLPTSLPTPLYVANEYAKRGRNLWNEAVALNNVPTVSGPEADRLKELTKSICYKASGDLTGRRVNA
Protein: Somatotropin (Growth hormone) (A3FEU9)
Organism: Oreochromis urolepis hornorum (Wami tilapia)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MNSVVLLLSVVCLGVSSQQITDSQRLFSIAVNRVTHLHLLAQRLFSDFESSLQTEEQRQLNKIFLQDFCNSDYIISPIDKHETQRSSVLKLLSISYGLVESWEFPSRSLSGGSSLRNQISPRLSELKTGILLLIRANQDEAENYPDTDTLHPPPYGNYYQSLGGNESLRQTYELLACFKKDMHKVETYLTVAKCRLSPEANCTL
Protein: Origin recognition complex subunit 1 (DmORC1) (O16810)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Origin recognition complex subunit 3
- Origin recognition complex subunit 4
- Double parked, isoform A
- Origin recognition complex subunit 6
- Origin recognition complex subunit 2
- Origin recognition complex subunit 5
- DNA replication licensing factor Mcm2
- Cell division control protein
- DNA replication licensing factor Mcm3
- DNA replication licensing factor Mcm5
Sequence:
MVNKENARSVGQQVKWIGSQDELPPVKNLEHKNVYFYQKCIYGPLTLSVGDFILVSNADAAEPDTVSGCDVARILHMYELRELTDREPCRAIVQWYSWPKAIPHNKYDDDEVAIDFSLEVIEEHRPYDNDVALGAIYRKCIVLEGTSKTSAEEILKRHANKLKSTACPMFVSRYRFVKVKRSYRLIPLEIHLEQPEDNARPTRSSRKSLTAHRESKRSISARHDDTAGNKGSSVEKRRRASMAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSEKKNAPEINANYLPASPLTEKNAKVETPKSRASAARRNLNLSLDRGADTTADSDCLNYSIVQQTPDPKTPSNDMKIKLRLSERRRSVRLASMDVDPLSLEEAVQEPNAQGRKRLGVANGDIYHTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRSIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKKSVQKTPTRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAVQLVARKVAAVSGDARRALDICRRATEIADTAAVKCVTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFQKILLNVSADDIHYALRVEEMVN
Protein: RRM domain-containing protein (Q9TZI2)
Organism: Caenorhabditis elegans
Interaction partners:
- RRM domain-containing protein
- DZF domain-containing protein
- RRM domain-containing protein
- Heterogeneous nuclear ribonucleoprotein K homolog
- Tar DNA-binding protein homolog 1
- Doublesex- and mab-3-related transcription factor dmd-4
- RNA helicase
- Probable splicing factor, arginine/serine-rich 6
- RRM domain-containing protein
- Splicing factor U2AF 65 kDa subunit
Sequence:
MSAEYGQYGYYGGAGGAQTTTTPAAALAASIPATSVYGEQRPTFSEDGTGAPYSTILNLVGSAAVNSDISYDTSSKDPHMIRARVFIGNIARAIITRDDIIELFRPFGKIIAVNYFAQQGFGFVQFNEAGSADESCRSLNGMSWKACCLDVHLAMLGSLRKPTGNEGRQGNTIAPAPLPVGKPLTQHAVDTSAQSAKRPYEDEEYEIFKQNKRNKQFANGDTTINEQLAPNEMCDTMVCGYCRFVTSDFEEFKEHRIAGCNKYKDPEEPRHRLKCATCSQRFLGAWGLLEHLTDFHRMLLYTEEKMTPNDLAQMRGGSVSTPSSIPETPASGSAAPAAPNSANSTPSHHIVEGAPLSYSSNNGTPQI
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC) (Q02158)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Interaction partners:
- Kinase
- Kinase
- PIPK domain-containing protein
- Probable phosphatidylinositol phosphate kinase DDB_G0267588
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Diacylglycerol kinase A
- 1-phosphatidylinositol 4-kinase
- Inositol monophosphatase
- 1-phosphatidylinositol 4-kinase
- Phosphatidylinositol 4-kinase
Sequence:
MDTLTNSQDYSNVDLSLESLAEELYNIQSFNKDVILDSFDIDDYDHTQLDTTIDFNKFKIGLTILKISSKGKPQKKKLIFDLARNQIVCGKKKKVNFSEIDEIRVGHKTNIFNQFKSSKNLKEDIESIQQSFSILFSGNLRKTMDFVCSDIPERRQIVSALYHVVQESKSVNNEYNFVKREWDRVGKDSIDFSTLKKILARLNFTTSDAVLHNLMKFSDSNSDYHLDFSEFSNLLKLLRSHPEMKPVFYKYNGGNGEWVPIQGMIDFFRIEQSEVWTVEQCRDLIKKYHHERLDCISFENFEEFICGEANLAQYPHTSTVYQDTSKPLSYYFINSSHNTYLSGHQLKGLSTSEMYTNTLRQGCKCVELDVWDGNDGDPIIFHGNTLTSQIKFSHVCETIKARGFETSPYPVILSLEVHCSVPQQIMMANHMKEIFGEMLPTPLPEGTKELPTLDSLKYKILLKGHTSHTHVSAVGNSSASSSQSNIQTDDNDDDGAVDLTEYDEVDDRSASSSSSSFSLSFGSSGKKKKITKIKIAPEFEELIYLVSHGFKSGNTTKEIPSYKIHSLVEEKVKQLVQSEPREVVEASQNHLLRVYPRGTRFDSSNFDPMPGWSIGCQLAALNQQTSSEPMWINDGMFSDNGGCGYVLKPPCLLPGECETYDPTSPERIKSSKYSRLIVNVISARQLPKYTKSTKGEVIDPYVTLSIVGTHFDQKVEKTKVIDNNGFNPHWGEEFEFPLYNSQLSMLLIRVDDKDKVGHNRIGHHCIRVENIRPGYRILKLKNNFNRTIPLANLLCKFTFVE
Protein: Metal tolerance protein 1 (AtMTP1) (Protein OVERLY ZINC SENSITIVE 1) (Zinc transporter of Arabidopsis thaliana 1) (ZAT1p) (Zn transporter ZAT-1) [Cleaved into: Metal tolerance protein 1 short form] (Q9ZT63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates zinc accumulation in roots and confers resistance to zinc. Involved in sequestration of excess zinc in the cytoplasm into vacuoles to maintain zinc homeostasis. Can also transport cadmium with a low efficiency.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15653794, ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:15653794}. Note=Tonoplast.
Interaction partners:
- Putative cadmium/zinc-transporting ATPase HMA4
- Metal tolerance protein 11
- Metal tolerance protein 9
- Putative metal tolerance protein C3
- Cadmium/zinc-transporting ATPase HMA2
- Putative inactive cadmium/zinc-transporting ATPase HMA3
- Metal tolerance protein C4
- Metal tolerance protein C1
- Metal tolerance protein 10
- Protein ZINC INDUCED FACILITATOR 1
Sequence:
MESSSPHHSHIVEVNVGKSDEERIIVASKVCGEAPCGFSDSKNASGDAHERSASMRKLCIAVVLCLVFMSVEVVGGIKANSLAILTDAAHLLSDVAAFAISLFSLWAAGWEATPRQTYGFFRIEILGALVSIQLIWLLTGILVYEAIIRIVTETSEVNGFLMFLVAAFGLVVNIIMAVLLGHDHGHSHGHGHGHGHDHHNHSHGVTVTTHHHHHDHEHGHSHGHGEDKHHAHGDVTEQLLDKSKTQVAAKEKRKRNINLQGAYLHVLGDSIQSVGVMIGGAIIWYNPEWKIVDLICTLAFSVIVLGTTINMIRNILEVLMESTPREIDATKLEKGLLEMEEVVAVHELHIWAITVGKVLLACHVNIRPEADADMVLNKVIDYIRREYNISHVTIQIER
Protein: nitric-oxide synthase (NADPH) (EC 1.14.13.39) (O93460)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
QEMLNYRLTPSFEYQADPWNHHVWKVNNGTPTKKRAIGSKKLAKAVKFSAKLMGQAMAKRVKATILFATETGKSQDYARTLCEIFKHAFDAKVMSMDEYDMVDLEHETLVLAVTSTFGNGDPPENGEKFGAALMEMRHPTSNTEDRKSYKVRFNSVSSYSDTRKSSSDEPEPRVNFESTGPLANVR
Protein: Tumor necrosis factor ligand superfamily member 4 (OX40 ligand) (OX40L) (CD antigen CD252) (Q9Z2P3)
Organism: Rattus norvegicus (Rat)
Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity).
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 4
- CD27 antigen
- TNF receptor superfamily member 9
- CD40 ligand
- Inducible T-cell costimulator
- TNF superfamily member 9
- T-cell surface glycoprotein CD4
- Tumor necrosis factor receptor superfamily member 8
- ICOS ligand
- Interleukin-4
Sequence:
MEGEGVQPPDENLENGSRPRFKWKKVLRLVVSGIKAAGLLLCVVYVCLQFSSSPAKDSPIQRLRAPVTGCEGGRLFIGTSKNEYETMEVQNNSVIINCDGLYLIHLKGSFFQEVKINLHFRKDRSPIFVPMLNNGQRVVFTVVTSLAFKDEVYLTVNASDTLCEHLQINDGELIIVQLTPNGYCAPERPYSSTVNQVPL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VQE3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNDYELETMLRINSIMVIRKLGSGSFGDIYEAKHMGSGLHVALKVERKNAGQSHLSIESTVYNLLRHGMGIPMTYQFFSNRRHDVLVMELLGPSLETLFTMCNRRFSMKTVLMLADQMVDRLEYLHLHHYVHRDIKPENFLMGVGLTRHRLHLIDFGLSKRYWDMKENRHVPQRRGTKWAGTARYASVNALCCKVQSRRDDLESVGYVLIYLLRGSLPWQGLLPNSKLQKAEMILEMKLSTLPNSLCAGYPNEFYNYIIYTRQLGFEEEPDYRMIRCTFLSLLFNLKFTNDLIYDWDHAEKNSGKSGSEEDRVVVKKVV
Protein: Gelsolin-related protein of 125 kDa (GRP125) (O96923)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in phototaxis. Required for coupling photodetection to the locomotory machinery of slugs. May be essential in the natural environment for the propagation of spores.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:9880334}.
Interaction partners:
- Gelation factor
- Extracellular signal-regulated kinase 2
Sequence:
MEEDNIVDSKEIENNVEDKKEETPSSSPSPSSSLQQQQEEGGVVKQAVSNLVSSSITLHDDAKLIQVTGKDEPFHFISVPMSVEFLNLEDVFIMQSDAYIFVWCSEQANIKKKAKAVQMAQKLKVEIGCQRAVQVLEIGEEHPTFLFCLGVPKGTKLNVTKEKNDIFQVDEDDEEQVLEPEFFLFKIFTGTDGKPSIKPMEEDEGINQEMLESSACFILDCEHEMYIWLGKGVKKSTKDTLIPVAKKIWTQYDRPEYYGKLKLQPIITWVFDGAESCLFKSKFSKWVEKAQPLQTSYLSLSSKKKEALNFDVSSMHQDKEVPVINIGAASDYSNGKLLVWCSGGGSGNKWNKVEEDDFGIFYSNKSYVCHFIYKPENKNSIRSVIFFWEGLYSNQRNYIGYKFGLYKEIQKKMEGLKSDDPVEYRISQNKEPQEFINLFGTELLVLNEELALKPMIFQVRANRGTQLFPDPDSCNAKLLNSLDSFVFLFPNKYIIVWHGKVSTEHQRELAADLFTFLPPEYEAGVKEFDQGKESDNFWKIIGGNSNDIVINTFINENKEEKEKEEEEKEEEEEEEEEEEEEEEEEKDNNKTTTIIKHLRPKKIKLFLCTDNSGIFKADQINPFSQVDLNSQECVLLDVYHKVFLWKGSKSTDQKLNDTQDLAKQYIETANDQRPSDCSVELVEQYNESPLFKSYFHSWKVTPPKVFIDPIISYKQKLAERLQKEKEDLEKLKQQQEQEQEQQQKENNKIVEEVKEEVKEEDVKEEVKEEEVKEEEVKEEEVKEVAKEETKEEIKEEVNDEATEVKEVNQVEEEVKEEEVKEEVKVEVKEEEVKGEAKEEEVKEEEVKEEEVKEEVKEVKEEVKEEVKQDKEEEVNEEIKEETKEEETKEDDNKEDEKVNEENETVNEENEVGIIVSPPSEKVDEANSSSTISSPENEGSVSVKDKRKSNEPITPSVVSSSGDLLFAYEPYHGPPIHSSNSPKQGRKGGRKSHGKNQPQHKKNHSVDQSPLSSPIIPNKSLNLDIDNQSFDLNSINNNNSVEVLDGASSPLSFSSSSINSNSTHNTPSKKNKNKNKKKHNRSSSLTHA
Protein: DNA-direcetd RNA polymerase II, subunit 9, putative (Q384T7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Spt4/RpoE2 zinc finger domain-containing protein
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerase subunit beta
- Transcription initiation protein, putative
- DNA-directed RNA polymerase subunit, putative
- DNA excision repair protein, putative
Sequence:
MESTLTQLDDAPMIFCERCNNLLYPESGKEDRVMRWRCNYCKTSEIHDENKLVYILNLKVKTSTVEELELLAEFANDPTAQRDTTKQCPRCAMNEVTCFVNPLGQPHEDMTLYFACANQGCRHVWKSSDHQDN
Protein: Elongator complex protein 5 (I3L2T0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQR
Protein: Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4a) (p16-INK4) (P51480)
Organism: Mus musculus (Mouse)
Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESAADRLARAAAQGRVHDVRALLEAGVSPNAPNSFGRTPIQVMMMGNVHVAALLLNYGADSNCEDPTTFSRPVHDAAREGFLDTLVVLHGSGARLDVRDAWGRLPLDLAQERGHQDIVRYLRSAGCSLCSAGWSLCTAGNVAQTDGHSFSSSTPRALELRGQSQEQS
Protein: NifU-like protein 5, mitochondrial (AtNfu-I) (AtNfu5) (Q9C8J2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Iron-sulfur cluster assembly protein 1
- Cysteine desulfurase, mitochondrial
- Lipoyl synthase, mitochondrial
- Lipoyl synthase, chloroplastic
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- Monothiol glutaredoxin-S14, chloroplastic
- Monothiol glutaredoxin-S15, mitochondrial
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Iron-sulfur protein required for NADH dehydrogenase, mitochondrial
- Fe-S cluster assembly factor HCF101, chloroplastic
Sequence:
MKGLTRLLNSLSRHTASVTCSPSSSSLLISRRSLFISAATHFPVNFSESITTNASRNCSRSSSFPFNWIEQRRTMFIQTQSTPNPSSLMFSPGKPVMEIGSADFPNSRSAMSSPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAVVMDFYSSGQPLFLDSQATAAKDTAIHEDDSETVAMIKELLETRIRPSVQDDGGDIEYCGFDTETGIVKLRMQGACSGCPSSSVTLKSGIENMLMHYVSEVKGVEQEFDGEEEGTSSGPME
Protein: Nephrocystin-1 (Q9QY53)
Organism: Mus musculus (Mouse)
Function: Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells, together with NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis; required for the differentiation of early elongating spermatids into spermatozoa.
Subcellular location: Cell junction {ECO:0000269|PubMed:12006559, ECO:0000269|PubMed:18477472}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9TU19}. Cell projection, cilium {ECO:0000269|PubMed:16885411, ECO:0000269|PubMed:19208653, ECO:0000269|PubMed:29899041}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19208653}. Cell junction, tight junction {ECO:0000269|PubMed:10739664}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (PubMed:19208653, PubMed:29899041). Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (PubMed:10739664). Localizes to respiratory cilia axoneme (PubMed:16885411). Localized to the transition zone of respiratory cilia (PubMed:16885411). Localized to the transition zone of photoreceptor-connecting cilia and renal monocilia (PubMed:16885411). In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates at basolateral tight junctions (PubMed:21565611). {ECO:0000269|PubMed:10739664, ECO:0000269|PubMed:16885411, ECO:0000269|PubMed:19208653, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:29899041}.
Interaction partners:
- Nephrocystin-4
- Protein fantom
- Meckelin
- Jouberin
- Nephrocystin-3
- Inversin
- Centrosomal protein of 290 kDa
- IQ calmodulin-binding motif-containing protein 1
- Coiled-coil and C2 domain-containing protein 2A
- Transmembrane protein 231
Sequence:
MLARRPRDPLQALRRRGQELKLQVDSLVTESQLTGALEPSKRREIYQRCIQLKQAVDENKNTLQKLNKADEAAPVGNYEQRKEEEHSLLEKLACQLQELAVSISRKDALKVEAHSDKEEDDTTEDDEEETGGEEEESEGDGEGKQEQASPKQAETETVTYIALGDFAAQQTGDLTFKKGDVLHIIEKKPDGWWLAKDAEGVEGLIPRTYLEPYNKEDKLESSEGSEEGGEEDGEEDVEVVDETADGAQVKQRTDSHWSAVRKAISEQINTVDVLATMGAIPAGFRPSTLSQLLDEAGNQFRASYFLQPELTTSQLAFRDLTWDAKAGTIMSRPSRVSLILTLWSCKMIPLPGTSIQVLSRHIRLCLFDGSKVLSNIHTVRAVWQPKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSTPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGVEVDPSVSRRAQGSVFRQMISVRRQPQLLVKLRSLNRRSRAMLSLLPETLVGSMCSAHLLIFYRQILGDVLLRDRTNLQSADLISHPVLATFPLLLEQPDVMDALRSSWSEKESTLKRAEKRDKELLKAEFLLVYHDCVLPLLHSTLLPPFRWAEEETEAARWKAIADFLKQSRENEGSLKALLSPDGVHKPFDLSEQTFDFLGEIRKNSG