wanglab/gogpt-training-data huggingface dataset:
Protein: M-phase inducer phosphatase (EC 3.1.3.48) (P30303)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.
Interaction partners:
- Polo-like kinase
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B
- DNA damage checkpoint effector kinase
- protein kinase C
- Protein kinase domain-containing protein
- Origin recognition complex subunit 2
- Origin recognition complex subunit 3, putative
- Origin recognition complex subunit Orc5, putative
- Negative regulator of the PHO system
Sequence:
MEHSSPLAAMQPPSVMLGHCFRSDAPTSYHGFSPLPGLGPGGFNFKDLSMKRSNGDYFGTKVVRGSSPTASLAADLSQNFHIDQSPQVATPRRSLFSACLLGNGNRRGVDDAMTTPPLPSSSPAPAMDIMDMSPLPHKPPFISTPEIELDSPTLESSPMDTTMMSTDGLVPDSPTVLPKDGKQERRRPTFLRPSLARSKAQSFQVGMTRPAPESQGPPFKFQTNGINKTSSGVAASLEDMFGESPQRERPMMRINSTSGLNSRLRPPLGSGSHVRGNGSPSAASVRKSAHPNMRPRKQCRRSLSMYEHPEDVIADSEVSYTSNAPLQSISDFEETQALQLPHFIPEEQADNLPRIDKATLVDIKEGKYDNMFDNIMIIDCRFEYEYDGGHIVGAVNYNDKENLAAELFADPKPRTAIVFHCEYSVHRAPLMAKYIRHRDRAYNVDHYPQLSYPDMYILEGGYSGFFAEHRSLCYPQNYVEMSAKEHEFACERGLGKVKQRSKLSRAQTFAFGQQSPEMEDSPTGRCRNNPGDRKLLASPFNDSPGSRFPGRRMLSY
Protein: Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte) (Q13336)
Organism: Homo sapiens (Human)
Function: Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:7797558}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8VHL0}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000250|UniProtKB:Q8VHL0}.
Interaction partners:
Sequence:
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
Protein: Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) (P14649)
Organism: Homo sapiens (Human)
Function: Regulatory light chain of myosin. Does not bind calcium.
Interaction partners:
- Myosin regulatory light chain 12A
- Myosin-10
- Myosin light polypeptide 6
- Myosin regulatory light polypeptide 9
- Myosin regulatory light chain 12B
- Myosin-9
- Myosin-11
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin light chain kinase family member 4
- Myosin light chain kinase 2, skeletal/cardiac muscle
Sequence:
MPPKKDVPVKKPAGPSISKPAAKPAAAGAPPAKTKAEPAVPQAPQKTQEPPVDLSKVVIEFNKDQLEEFKEAFELFDRVGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELKSRRVDFETFLPMLQAVAKNRGQGTYEDYLEGFRVFDKEGNGKVMGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGCINYEAFLKHILSV
Protein: Putative S-(hydroxymethyl)glutathione dehydrogenase 2 (EC 1.1.1.284) (Alcohol dehydrogenase 2) (EC 1.1.1.1) (Glutathione-dependent formaldehyde dehydrogenase 2) (FALDH 2) (FDH 2) (FLD 2) (GSH-FDH 2) (EC 1.1.1.-) (O74540)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Alcohol dehydrogenase 4
- Alcohol dehydrogenase
- Putative pyruvate decarboxylase C13A11.06
- Probable pyruvate decarboxylase C186.09
- Putative pyruvate decarboxylase C3G9.11c
- Probable pyruvate decarboxylase Pdc101
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Putative aldehyde dehydrogenase-like protein C922.07c
- Zinc-type alcohol dehydrogenase-like protein C2E1P3.01
- Uncharacterized oxidoreductase C26F1.07
Sequence:
MQQSPTAGKIINCKAAVAWQPAAPLSIENVQVFPPRVHEVRIKIVNSGVCHTDAYTLSGKDPEGLFPVILGHEGAGIVESVGPQVTTVQVGDPVIALYTPECKTCKFCKSGKTNLCGRIRTTQGKGLMPDGTSRFSCNGNTLLHFMGCSTFSEYTVVADISVVAIERLAPLDSVCLLGCGITTGYGAATITADIKEGDSVAVFGLGSVGLAVIQGAVKKRAGRIFGIDVNPEKKNWAMSFGATDFINPNDLQSPIQDVLIHETDGGLDWTFDCTGNVHVMRSALEACHKGWGQSIVIGVAAAGQEISTRPFQLVTGRVWRGCAFGGVKGRSQLPDLVKEYLDHKLEIDKYITHRRPLKEINEAFTDMHNGNCIKTVLSIP
Protein: Lipopolysaccharide export system permease protein LptF (A0A421IFY4)
Organism: Enterobacter cloacae
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
Sequence:
MIIIRYLVRETLKSQLAILFILLLIFFCQKLVKILGAAVDGEIPTNLVLSLLGLGIPEMAQLILPLSLFLGLLMTLGKLYTESEITVMHACGLSKAVLVKAAMILALFTGIVAAVNVMWAGPMSSRHQDEVLAEAKANPGMAALAQGQFQQATDGNSVLFIESVDGSKFNDVFLAQLRTKGNARPSVVVADSGQLAQRKDGSQVVTLNKGTRFEGTAMLRDFRITDFQNYQAIIGHQAVALDPTDTEQMDMRTLWNTDTDRARAEFHWRITLVFTVFMMALIVVPLSVVNPRQGRVLSMLPAMLLYLIYFLLQTSIRSNGAKGKLDPMVWTWFVNSLYILLALGLNLWDTVPVRRIRARFSRKGAI
Protein: Palmitoleoyl-protein carboxylesterase notum1 (EC 3.1.1.98) (A0A0D3QS99)
Organism: Xenopus laevis (African clawed frog)
Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Functions in the prospective ectoderm and is required for neural induction.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
Interaction partners:
Sequence:
MAGALCVTLLLLLSTNTVSGRKTWRRRGQQIVPSGRERSEGGDESFPLDFTAVEGNMDNFMAQIKSLAQSLYPCSAQRLDDEMKLHILHNKSVTCNDGSSAGYYLKESKGSRRWLVFLEGGWYCISHENCDLRYDTMRRLMSSKAWPPAKTASGILSTQPEENPHWWNANMVFIPYCSSDVWSGASPKTEKSGYAFMGSLIIQEVVKELLGKGLDAAKVLLLAGSSAGGTGVLLNVDLVADLLEELGYPGIQVRGLSDSGWFLDNKQYRRTDCTDIITCAPTEAIQRGIRYWSSMVPERCKQQFKEGEEWNCFFGYKIYPTLRSPVFVVQWLFDEAQLTVDNVHLSGQPVQESQWLYIQNLGRELRNTLKDVGASFAPACLAHEVITRSHWTEIQVRGTSLPRALHCWDRRLQETNKNSKVPLKGCPFHLMDSCPWPQCNPTCPSIRDHFTGQEMSVVQFLMHLGFDVQKMASQQGMEPGKLLGVLSS
Protein: Photosynthetic NDH subunit of subcomplex B 2, chloroplastic (Protein PnsB2) (NAD(P)H DEHYDROGENASE SUBUNIT 45) (NDH-DEPENDENT CYCLIC ELECTRON FLOW 2) (Q94AQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18785996, ECO:0000269|PubMed:18974055}; Peripheral membrane protein {ECO:0000269|PubMed:18974055}.
Interaction partners:
- Photosynthetic NDH subunit of subcomplex B 3, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 1, chloroplastic
- NAD
- NAD
- Photosynthetic NDH subunit of subcomplex B 4, chloroplastic
- NAD
- NAD
- Photosynthetic NDH subunit of subcomplex B 5, chloroplastic
- Photosynthetic NDH subunit of lumenal location 3, chloroplastic
- Photosystem I chlorophyll a/b-binding protein 6, chloroplastic
Sequence:
MASLISFSLLPKPKAVRSSISAPQTQTINTEKLEDKFGRKGIKFSESNNIPMVELKVRNGSSLKLSLSDAHVLSYKPKVYWKDEGFEEVLYTVDGDESRGGVGVVIVNGEEPKGGSSVISGCDWSVKDTDSDAIDALQIELSCTAGVLDITYIVSLYPVSMATALVVKNNGRKPVTLKPGIMSYLRFKKRSGAGIQGLKGCSYCPNPPLSSPFELLSPSEAMKAESSGWFGSEEGEKPGIWAVEDSVITLLEKKMSRIYGAPPAERLKAVYNTPPSKFETIDQGRGLFFRMIRIGFEEMYVGSPGSMWDKYGKQHYFVCTGPTSMLVPVDVASGETWRGAMVIEHDNL
Protein: Nephrocystin-3 (P0CI65)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase Nek8
- Protein unc-119 homolog B
- Si:dkey-202c5.1 protein.
- Nephronophthisis 1.
- IQ calmodulin-binding motif-containing protein 1
- Inversin
- Centrosomal protein of 290 kDa
- Protein fantom
- IQ motif-containing B1.
- Meckelin isoform X1
Sequence:
MGTASSLVSPGEVIEDAYGGEGGEACEIPVEVKPKARLLRSSFRRGPRVIGASFKSTGSVELEYAAEYERLRKDYEIFRVSKNNEITSMQKKEAKLDEENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKEKEIQDLLRAKRDLESKLQQLQAQGIQIYDPADSDSDDNHTTVTTAGTQCEYWSGGVLGSEPSMGSMMQLQQTHRGPEFAHSLIDVEGPFANVSRDDWDAAVASLLQVSPHVSQSLWSNTVRCYLIYTHETKAELQTFIQTYSLRLRRFCEGLGHFYLNVSFPEEKAAVFAAERRREMERSSVCVLLLKSSVSSCVVEDVEEAFVKTPDARPLLLYLRTADRKGEKEEVSTLSPATRDLLERVNKADRSAKLKVVDHAGSVEEGAALIFSQLERIIKQELLGLELEENGVVEEREEEDSGDVLWDLHDEQEQIEAFQQACGAAARFSFQKYVDRLNDMVAAPPPTPPLLVSGAPGSGKSLLLAKWIELQQKHSPNTLILYHFTGRPLSTSTDPVLIIKRLTVKLLQHFWSISGLSMDPSKILEEFPRWLERLSARHHGNIIIIIDSIDQIQNAERHMKWLIDPLPANVRVLVSVNVETCPQAWRLWPTLHLDPLNPREVKSVISTECVSVDIKLSKDQEKKLEKHCRSAATCNALYVSLLARLITHFSTSWTLDRTLQQCVMCQDTVSLYRLGLKVALDSLNSDQEKHIMKELLCLVCASHNGISESEVLELFPDLTFPALISMLHNLERLLIITYACGLIRFQHSQACEGVNQEFLDGDKCRGSYREKCIRFFSQQLEQDRVTWRVADELPWLLQQQEDRSKLQMSLLNLFVSQNLYKRGHFSELLAYWQFVGKDKCSMATEYFDALKEFEKTCESEQSMSRLANLYETLGRFLKDLGLLSQAVAPLQRSLEIRETALDPDHPSVAQSLHQLAGVYVHWRKFGNAEQLYKQAMEICENAYGPEHSTVARELDSLSLLYQKQNKYEQAEKLRKRSVKIRQKTARQKGHMYGFALLKRRALQLEELTLGKDSTDCAKTLNELGVLYYLQNNLDAAKLFLTRSLEMRQRVLGPDHPDCAQSLNNLAALHSERKEYESAEELYERALDIRKRALAPDHPSLAYTLKHLAMLYKRRGKLEKAVPLYELALEIREKSFGPKHPSVATALVNLAVLYCQLKQHSDALPLYERALKVYEDSLGRLHPRVGETLKNLAVLSYEEGDFEKAAELYKRAMEIKEAEPSLVCGKAPSRHSSSGDTFSMRSPALPNASR
Protein: Citrate synthase (Q8I6U7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Aconitate hydratase
- ADP/ATP translocase
- Citrate/oxoglutarate carrier protein, putative
- acetate--CoA ligase
- non-specific serine/threonine protein kinase
- Cysteine proteinase falcipain 1
- Uncharacterized protein
- Kelch domain-containing protein, putative
- Syntaxin, Qa-SNARE family
- P1/s1 nuclease, putative
Sequence:
MEGIRYLSCNKILYKRTGSTKTLINSLRKRYVHNNFKKKTCEQVLNTVNKLHNEKRYFNFSCSFTKSSRWNICMNRHNSRFFSSNESNKNLYLENYANIRKHINSIDNEESVIMNILKEKTYECIKKTREQLKEIIHTYPNTPISICTPNNVIGGLRNTITLITDTSILEKKKGILFRGKPVEKILREFPKWDNTCEYPMAEAMLWFLLTKEVPAVDDLKLLSRELYCRAKKIPQFVFDFIDNIPPFTHPMSQLVSTVSFLESLSLFKYKYSEGILKTDYWKYILEDAISLISQIQVIGAYIFKRTFINNDIRKGEGMNLDLDLDWSANFAKLIGYENKEVQDLLRLYFLLHSDHEGGNASAHVSHLIGSTLGNPYLSYSGCVIALSGPLHGLANQECLKFLLDIKKQLGDNQLTYEFIEKYAKNLLKSGRVIPGYGHAVLRVPDPRFLALRSFALSHFPDDPIIQILEMCYKVIPGILSATGKVKNPYPNVDCSSGSVLHHYGIKYPEYYTVLFALSRSIGVMSQLVLSRGLMYPLERPKSVDIYNLRKICEKNYVKIEEYE
Protein: Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) (O14792)
Organism: Homo sapiens (Human)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
Subcellular location: Golgi apparatus lumen {ECO:0000305}.
Interaction partners:
- Heparan sulfate 2-O-sulfotransferase 1
- Sulfotransferase 1C3
- Sulfotransferase 1B1
- Sulfotransferase 1C4
- Uronyl 2-sulfotransferase
- Heparan-sulfate 6-O-sulfotransferase 1
- D-glucuronyl C5-epimerase
Sequence:
MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH
Protein: Zn(II)2Cys6 transcription factor (Eurofung) (Q5B7W1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MFHTFEGFENPAASAPARAGRERQSSIGRRVTTLRACTSCRHRKIKCDGEKPCEACRWYKKADLCHYSDPRPSRRHVEKLSTTLDEYRTVLEKLFPGASPEALANLPREKLLETLAQPQAQPPSTGARQISPATSTSHEAHVSPISTEDGNLESLQAMPEESNDPRNLSSEITNTISDDVNALSLSTRGPSSYLGVSSINAVLKTIVWLDPGSAAYFASTPPSAPRRGSVADLSSSEGQSWAAHDQPGTPPQVHLQVPESQLLDAYFTYVQPLTPILDEQSFRETYAAGHRKDDRWYCLLNIVLAMGSICASTCDDISHKIYYSRCRAYLDLESLASLHLETVQTLGILGGWYLHYVAQPNLAYSLMGAALRMAATMGLHREFADQSDTSNKQKMAQLDLRRRVWWTLFLMDCWGGVTLGRPTMGRFSPAITVKLPHYRESGNVLDILPLLENVRFCKISNQIQDALAVSPLTKYSEILHFDTQLVEWYNSLPYILKDHEPCPEGIANTREVTKWRYHVQRILLYRPTLLSYAMRRVPYIALRSEERTAIERCREIAETAIRDISATAKTPQMSGWNAVWFLFQSTMVPLLGLFINDNTVTDPRATTEACQAQVQDALLVFARLQQASPTARKTLDAVSRIFEASKRGPGIAAETNSINSANLSPTSREAGVLNTPGILPSHNDGRGFAVTHDSSFTDPFAPSTMDDPNGQYLWDFLSWSDTNIVPMADVENINDGGLLGSDDKHFKYTNTSFFGNQLTEPPFFTNSSIPYYS
Protein: Metal-activated transcriptional activator protein AMT1 (P41772)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Trans-acting regulatory protein that activates transcription of the MT genes (metallothionein) in response to copper or silver ions.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MVVINGVKYACDSCIKSHKAAQCEHNDRPLKILKPRGRPPTTCDHCKDMRKTKNVNPSGSCNCSKLEKIRQEKGITIEEDMLMSGNMDMCLCVRGEPCRCHARRKRTQKSNKKDNLSINSPTNNSPSPALSVNIGGMVVANDDILKSLGPIQNVDLTAPLDFPPNGIDNKPMESFYTQTSKSDAVDSLEFDHLMNMQMRNDNSLSFPMSANQNEVGYQFNNEGNNSMNSTMKNTITQMDQGNSHSMTLHDIDEILNNGIELGNVN
Protein: Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family (Q9M386)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Late embryogenesis abundant
- Transcription factor bHLH109
- Late embryogenesis abundant protein ECP63
- Late embryogenesis abundant protein 46
- Desiccation-related protein At2g46140
- Protein SENESCENCE-ASSOCIATED GENE 21, mitochondrial
Sequence:
MSDFSIKPDDKKEEEKPATAMLPPPKPNASSMETQSANTGTAKKLRRKRNCKICICFTILLILLIAIVIVILAFTLFKPKRPTTTIDSVTVDRLQASVNPLLLKVLLNLTLNVDLSLKNPNRIGFSYDSSSALLNYRGQVIGEAPLPANRIAARKTVPLNITLTLMADRLLSETQLLSDVMAGVIPLNTFVKVTGKVTVLKIFKIKVQSSSSCDLSISVSDRNVTSQHCKYSTKL
Protein: long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) (X6R3N0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPKPPKPRNNLEDRHNPGIQGRREHRPGPGRVRAASSPGGSAPRAERRLWGEGWESGAAPHPHSSRVSALRPCGVVGAWVGMGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKRALRARALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSRRFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI
Protein: Kotsubu (RE70955p) (Q9VFP5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein piwi
- Tudor domain-containing protein krimp
- Probable ATP-dependent RNA helicase spindle-E
- Innexin inx4
- Protein matrimony
- FI02030p
Sequence:
MEKSEEKTCVVCGTPTRLMCQRCGEPYCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQSVENQVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVANVEAIERMTVNMQRCMQNKKMIRMEGVREDTLVAISVGDKVHRGHVLTVCQKKQEANVRMIDHGQIVATPFRDIYTIVPKMAESKAFAFRVQLPTNTGVQDIKNLTLRMLGTKTSDGAYHVHLKPKMIIPLSLPLEMLQLNPEVKVIRVFKANPKHNEPQLALLQINVMGHVNADLNNRIAEKPRQPFTLPFPEQKSIFFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIATDLSRIPSELLGLPSRVFAAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQISYLGHKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLVVSKQMGHFRGEILSKDSGLFEVMNVDTGATQKVELAEIRSSCRFLENLPVCLMRVQLQNVCNIPDAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQEKAEVAPPKAASTPSQLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTKSASHVLPIKRFLFDALPKNLAPLGDKVNLILMNADGLPQTGYITAAYFKDEKAAKEFEKILSLTSSQGACDHNVVPGYVPNVGELCLAIYSEDKNWYRGVCQEVKDNMVKILFCDFGNTEYVAVRHVKPISQDLLIAVNVTKCYINGFDKSKNFAALEQFLVRKIRFLCGVKKGPEPDTRLITIPDMETILNTPVA
Protein: Protein GOLVEN 11 (CLAVATA3/ESR (CLE)-related protein CLEL8) (CLE-Like protein 8) (Root meristem growth factor 1) (AtRGF1) [Cleaved into: GLV11p (RGF1p)] (Q3E880)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a peptide hormone recognized by receptors (e.g. RGI1 and RGI2) to trigger signaling events including the regulation of RITF1 expression and leading to the production of reactive oxygen species (ROS) in roots to modulate meristem size. Signaling peptide (root growth factor) that maintains the postembryonic root stem cell niche in a PIN2-traffic dependent manner by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT), mainly at the post-transcriptional level. Maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (e.g. PLT1 and PLT2), mainly at the post-transcriptional level. Influences circumferential cell number in the root meristem in response to Pi-deprivation. Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells.
Subcellular location: [GLV11p]: Secreted {ECO:0000269|PubMed:20798316}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase RGI3
- Protein GOLVEN 5
- Protein GOLVEN 7
- Protein RGF1 INDUCIBLE TRANSCRIPTION FACTOR 1
- Protein-tyrosine sulfotransferase
- Protein GOLVEN 1
- Protein GOLVEN 6
- Protein GOLVEN 3
- Protein GOLVEN 9
- At3g60670
Sequence:
MVSIRVICYLLVFSVLQVHAKVSNANFNSQAPQMKNSEGLGASNGTQIAKKHAEDVIENRKTLKHVNVKVEANEKNGLEIESKEMVKKRKNKKRLTKTESLTADYSNPGHHPPRHN
Protein: Angiopoietin-2 (ANG-2) (O35462)
Organism: Rattus norvegicus (Rat)
Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O15123}.
Interaction partners:
- Angiopoietin-1 receptor
- Tyrosine-protein kinase receptor Tie-1
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Angiopoietin-1
- Vascular endothelial growth factor receptor 3
- Angiopoietin 4
- von Willebrand factor
- Platelet-derived growth factor receptor beta
- Endothelin-1
Sequence:
MWQIVFLTFGCDLVLASAYNNFRKSVDSTGRRQYQVQNGPCSYTFLLPETDSCRSSSSPYMSNAVQRDAPLDYDDSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTRKLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHSVQLQSMKEQKDQLQVLVSKQSSVIDELEKKLVTATVNNSVLQKQQHDLMETVNSLLTMMSSPDYKSSVAVPKEEKTTFRDCAEIFKSGLTTSGIYTLTFPNSTEEVKAYCDMDMGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNEFVSQLTSGHRYVLKIQLKDWEGSEAHSLYEHFYLSGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKCICKCSQMLTGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
Protein: Protein MIX23 (Coiled-coil domain-containing protein 58) (Q8R3Q6)
Organism: Mus musculus (Mouse)
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim9
- Small ribosomal subunit protein mS35
Sequence:
MAAPSGSVNCEEFAEFQELLKVMRTIDDRIVHELNTTVPTASFAGKIDASQTCKQLYESLMAAHVSRDRVIKNCIAQTSAVVKSLREEREKNLDDLTLLKRLRKEQTKLKWMQSELNVEEVVNDRSWKVFNERCRVHFKPPKNE
Protein: MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (XIC) (Q98SK0)
Organism: Xenopus laevis (African clawed frog)
Function: Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins in the cytoplasm and inhibits their transcriptional activation (By similarity). Required for dorsoanterior development. Necessary for siamois to activate downstream target genes, including gsc, during execution of the dorsal organizer program. Also regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Involved in the development of lymphatic vessel valves. It is required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9P1T7}. Cell membrane {ECO:0000250|UniProtKB:Q8BX65}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BX65}. Secreted {ECO:0000250|UniProtKB:Q8BX65}.
Interaction partners:
Sequence:
MSQEREPFSPRPEGPEQVTSTEESLLVPLPHGKCEKENMDLEDTTLYRNKSIQTDIEDRSILEDNSNSQPIKAQPQRLPQPNTSALEQSEEETGKIQNGHVGLSNINGIHNGVKHVPADHRNISAPVSQKMHRKIQSSLSVSSDGSKKSKESSAYSQKPSASPEDGCVHCILTCLFCEFLTLCNIVVGQASCGICTSEACCCCCTEEMGDDCNCPCDMDCGIMDACCESSDCLEICMECCGICFPS
Protein: MHC class I antigen (Q6QMF2)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
AAALTMIQTRAGPHSMRYFETAVFGPGLGEPRFISVGYVDNTQFVSFDSDAENPRSEPRSPWMEQEGPEYWERETQIAKDNEQSFGWSLRNLIHYYNQSKGGFHTFQRLSGCDMGLDGRLLRGYLQFAYDGRDYIALNEDLKTWMAADLVALITRRKWEQAGAAELYKFYLEGECVEWLRRYLELGNETLLRTDPPKAHVTRHPRPAGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQNYTCRVHHEGLPEPLTLRWEPPPSTGSNMVNIAVLVVLGAVIIIEAMVAFALKSRRKIAILPGPA
Protein: Cytosolic neutral trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (Neutral trehalase) (O42893)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolyzes intracellular trehalose to glucose. The disaccharide trehalose serves as a storage carbohydrate that is mobilized during nutrient stress and spore germination. Together with tps1, regulates the level of trehalose as a protectant for cell integrity during heat, osmotic and oxidative stresses.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Alpha,alpha-trehalose-phosphate synthase
- Trehalose-phosphatase
- Trehalose-phosphatase
- Putative alpha,alpha-trehalose-phosphate synthase 106 kDa subunit
- Putative alpha,alpha-trehalose-phosphate synthase 100 kDa subunit
- Catalase
- cAMP-dependent protein kinase catalytic subunit
- Phosphoglucomutase
- Glutathione peroxidase-like peroxiredoxin gpx1
- Transcription factor atf1
Sequence:
MPSKFSSKYVDTEAISNDDDNPFATAKSYYSKDTDLSTRVSAGRPRTLSTSMEASAAPTIPELKNLRRRGSLDEHKQPRKFLVDVDKTLNALLESEDTDRNMQITIEDTGPKVVSLGSASSGGYRLYELRGTYQLSNLLQELTLAKDYGRRYILLDERRLNENPVNRLSRLIKGTFWDALTRRIDASVLDVICRDTKDRSGSHVNRIYVPKAEQEMYEYYVRAAKERPYLNLQVEYLPEEITPEWVRDVNDKPGLLALAMEKYQDDEGNTHLRGVPFVVPGGRFNELYGWDSYFESLGLLVDDRVDLAKGMVENFIFEITYYGKILNANRTYYLLRSQPPFLTDMALRVYERIKNEEGSLDFLHRAFSATIKEYHTVWTATPRLDPKTGLSRYRPGGLGIPPETEASHFEHLLRPYMEKYHMTLEEFTHAYNYQQIHEPALDEYFVHDRAVRESGHDTTYRLEKVCADLATVDLNSLLYKYETDISHVILEYFDDKFVLPNGTIETSAIWDRRARARRAAMEKYLWSEADSMWYDYNTKLETKSTYESATAFWALWAGVATPRQAAKFVDVSLPKFEVAGGIVAGTKRSLGKVGLDNPSRQWDYPNGWSPQQILAWYGLIRYGYEEETRRLVYRWLYTITKSFVDFNGIVVEKYDLTRPVDPHRVEAEYGNQGVNIKGVAREGFGWVNASYEVGLTFCNSHMRRALGACTTPDVFFAGIKEESLPAFENLSIHKN