Protein: Integrin alpha-V (Vitronectin receptor subunit alpha) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] (P26008)
Organism: Gallus gallus (Chicken)
Function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P06756}.
Interaction partners:
- Integrin beta
- Integrin beta
- Integrin beta
- Integrin beta
- SMB domain-containing protein.
- Integrin beta-1
- Transforming growth factor beta-1 proprotein
- Osteopontin
- Uncharacterized protein.
- Integrin-binding sialoprotein
Sequence:
MAALRASLLLSCALTAARAFNLDAERPAVYSGAEGSYFGFAVDFFAPDASSMFLLVGAPKANTSQSNVVEGGQVLQCNWNSNRNCQPIIFDSTGNRDFAPDDPLEFKSHQWFGASVRSKNDKILACAPLYHWRTETKQEREPVGTCYLFDGSKSVEYAPCRSTTIDADGQGFCQGGFSIDFTKGDRVLLGGPGSFYWQGQLISDRVAEILAKYDSKVYSTKYDDQLATRPASAAFDDSYLGYSVAVGDFSGDGIEDFVSGVPRAARTLGMVSIYNGKNMSSMYNFTGEQMAAYFGYSVATTDINGDDYTDLFIGAPLFMDRGSDGKLQEVGQVSICLQRASGGFQIAKLNGFEIFARFGSAIAPLGDLDQDGFNDIAVAAPYGGEDKRGLVYIYNGRATGLNAVPSRILEGQWAARTMPPSFGYSLKGATDVDKNGYPDLIVGAFGVDTAVLYRARPVIRVNAALEVNPTILNPENKACSLADVKVSCFKVKFCLKADGKGKLPNSLNFQVELLLDKLKQKGAIRRALFLHSKQPSHSKNMTITKGGKMNCEELDAFLRDESEFRDKLTPITIFMEYRLDYKTAVDATGLHPILNQFIPANMSRQAHILLDCGEDNICKPKLEVSVRSDQKKIYIGDDNPLTLIVTAENQGEGAYEAELFVIVPPQADFIGVVRNNEALARLSCAFKTENQTRMVVCDLGNPMKAGTKLLAGLRFSVHQQSEMDTSVKFDLQIRSSNLFDNLSPVAFYQVDLAISAAVEIRGVSSPDHIFLPIANWQPKENPETEDDIGPLVQHIYELRNNGPSAFSKVMMTLQWPYKYKNYTLLYIVQYDIDGPMNCTSDMEINPLKIKISAPKEDEKNETFSREDNRNHRISRRDLTAIEGDVQTLGCGNADCLKIVCQVGHLERGKSAILYLKSRLWTQTFMNKENQNHSYSLQSSASFNVIEFPYKNLSFEDIHNSTVVTTNITWGIQPQPMPVPVWVIILAVLAGLLLLAVLVLVMYRMGFFKRVRPPQEEQEREQLQPHENGEGTSEA