wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) (Q63468)
Organism: Rattus norvegicus (Rat)
Function: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
Interaction partners:
- Ribose-phosphate pyrophosphokinase 2
- Phosphoribosyl pyrophosphate synthase-associated protein 2
- Ribose-phosphate pyrophosphokinase 1
- ribose-phosphate diphosphokinase
- Ribose-phosphate pyrophosphokinase 1
- Influenza virus NS1A binding protein
Sequence:
MNAARTGYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFCFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAETLKERGAYKIYVMATHGILSAEAPRLIEESPIDEVVVTNTVPHELQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNITVDD
Protein: Transmembrane protein (Q57YY1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- ATPase subunit 9, putative
- Uncharacterized protein
- Uncharacterized protein
- ATP synthase subunit beta
- Uncharacterized protein
- ATPase subunit 9, putative
- Uncharacterized protein
- ATP synthase alpha chain
- Uncharacterized protein
Sequence:
MLPTRHINFAFISPLLGVLYLYTTNISIRIGQYSTGRTLRASQCFGYTRYSSVTQKKKKRSLGSLEVMWRFGASSTGLKAGSPLVGSASRRCGSTATPSRRRSGFFKMGDMYKPGRYTSKDLPKGPSGSNQPWDPVYANYAFQLVTGPLKRKQNTTPDDHLTVDELDKWMDAKGAAKVLGIKEEELPTLTAPAVEEYWAKAYGQRNNAHQQETVIAAEVLLEYIDSTVHRKKSRQYYRRYMDNARQAIDHETEMRRSEHRQKFIHLFGVAMFTGSAIVVIIAFFRGYFTRQDVEKIGTDAAAYLNMVFSQPPNLEPPPDYSTRYRDTPPAMELAKQQGVYGVVDPARLSNLSKDVKQYRADEEMEMLRMLNDENDKARQRRKGDQVRESRVVVYRAGDFDDAGELKDLAKEKEAVKPLSAFSQQSFRDFAALMASQFGGGSRFQRITQDSVRRAEEMERMQKRMNEIEE
Protein: Post-transcriptional regulator MTA (MTA) (EB2 protein homolog) (Q2HR75)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins. Probably acts as a viral splicing factor that regulates viral RNA splicing. Functions as a multifunctional regulator of the expression of viral lytic genes.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:20159985}. Host nucleus {ECO:0000269|PubMed:23077296, ECO:0000269|PubMed:29084250, ECO:0000269|PubMed:30096191, ECO:0000269|PubMed:31400113}. Note=Distributes in host nuclear splicing speckles. {ECO:0000269|PubMed:18184716}.
Interaction partners:
Sequence:
MVQAMIDMDIMKGILEDSVSSSEFDESRDDETDAPTLEDEQLSEPAEPPADERIRGTQSAQGIPPPLGRIPKKSQGRSQLRSEIQFCSPLSRPRSPSPVNRYGKKIKFGTAGQNTRPPPEKRPRRRPRDRLQYGRTTRGGQCRAAPKRATRRPQVNCQRQDDDVRQGVSDAVKKLRLPASMIIDGESPRFDDSIIPRHHGACFNVFIPAPPSHVPEVFTDRDITALIRAGGKDDELINKKISAKKIDHLHRQMLSFVTSRHNQAYWVSCRRETAAAGGLQTLGAFVEEQMTWAQTVVRHGGWFDEKDIDIILDTAIFVCNAFVTRFRLLHLSCVFDKQSELALIKQVAYLVAMGNRLVEACNLLGEVKLNFRGGLLLAFVLTIPGMQSRRSISARGQELFRTLLEYYRPGDVMGLLNVIVMEHHSLCRNSECAAATRAAMGSAKFNKGLFFYPLS
Protein: Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (D1A7C3)
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)
Function: Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.
Interaction partners:
- Sulfatase
- Sulfatase
- Histidine N-alpha-methyltransferase
- non-specific serine/threonine protein kinase
Sequence:
MPSFDFDIPRRSPQEIAKGMVAIPGGTFRMGGEDPDAFPEDGEGPVRTVRLSPFLIDRYAVSNRQFAAFVKATGYVTDAERYGWSFVFHAHVAPGTPVMDAVVPEAPWWVAVPGAYWKAPEGPGSSITDRPNHPVVHVSWNDAVAYATWAGKRLPTEAEWEMAARGGLDQARYPWGNELTPRGRHRCNIWQGTFPVHDTGEDGYTGTAPVNAFAPNGYGLYNVAGNVWEWCADWWSADWHATESPATRIDPRGPETGTARVTKGGSFLCHESYCNRYRVAARTCNTPDSSAAHTGFRCAADPL
Protein: Oogenesin-1 (E9Q5G7)
Organism: Mus musculus (Mouse)
Function: May down-regulate the expression of spermatogenesis-associated genes in female germ cells allowing their normal differentiation into oocytes. May act as a Ras-mediated signaling protein in early embryogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:12890732, ECO:0000269|PubMed:16580637}. Cytoplasm {ECO:0000269|PubMed:12890732, ECO:0000269|PubMed:16580637}. Note=In early one-cell embryos, exists only in the cytoplasm and gradually moves to the nucleus at the middle one-cell stage. At the late one-cell and early two-cell stages, higher levels in nucleus than cytoplasm. After the middle two-cell stage, mainly cytoplasmic and completely cytoplasmic after the four-cell stage. {ECO:0000269|PubMed:12890732}.
Interaction partners:
- Ubiquitin-like protein FUBI
- PRAME like 51
- Oogenesin-3
- PRAME like 47
- PRAME like 13
- D5Ertd577e protein
- Oog4 protein
- PRAME like 15
- Preferentially expressed antigen in melanoma-like protein 1
- Oogenesin-2
Sequence:
MVICLHCPDQDDSLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGYIGILKAMIPVWPFPYLSLGKQINNCNLETLKAMLEGLDILLAQKVQTSRCKLRVINWREDDLKIWAGSHEGEGLPDFRTEKQPIENSAGCEVKKELKVTTEVLRMKGRLDESTTYLLQWAQQRKDSIHLFCRKLLIEGLTKASVIEIFKTVHADCIQELILRCICIEELAFLNPYLKLMKSLFTLTLDHIIGTFSLGDSEKLDEETIFSLISQLPTLHCLQKLYVNDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDCLPYCLNICELKHLHISDIYLCDLLLEPLGFLLERVGDTLKTLELDSCCIVDFQFSALLPALSQCSHLREVTFYDNDVSLPFLKQLLHHTALLSQLIYECYPAPLECYDDSGVILTHRLESFCPELLDILRAKRQLHSVSFQTTKCSKCGGCYIYDRHTQCCRFVELL
Protein: Phospholipase C beta-4 (Q9Z2T3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQ
Protein: C2H2-type domain-containing protein (O01961)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RBR-type E3 ubiquitin transferase
- RBR-type E3 ubiquitin transferase
- RBR-type E3 ubiquitin transferase
Sequence:
MAESCVKPQLPRPRIPNIRVFQPTTRIPTFTYEQFNESVEILPSRPECLYRRNDPTNRSYRMKKRPPAQIYHCVQCNKHIKYPSKITEHIRKHTGEKPNVCSICNISFSQAHTLKTHMQQHAHEKPYKCSFCTAEFLNVYEKNEHEEQHMHHPNHGETMEENNATTSQFIQVAEPTIQAEPCQIYECSEMCGFQSYEEAEVVEHMTVTHYQQTVQNGLILQDFNGEPEPIYEFYEEQYVQQVPTEIEETPTIKQQSIPYENLHFEHVEAAPGPSEPHLQVVAEGEILYDGEEIVDISNGKSLKEEIQNGDANIYGMIQDLEEEVEDIGNEDEERERVRIMVNPNPPKRGTKSLRDHHEATAATMEMIVDASILELAEPSRHLKQGYPPISKRKNTGKRAENLDWIIDAVAKGVDVSEASPHHRKKPTLHKCEYCGRVDKYPSKIRAHMRTHTGEKPFKCEICGMAFSQKTPMRLHLRRHFDQKPYECDVDGCKERFVSGAILKMHVEKKHLNKKKYVCSRGCGRVFSSAYNQKHHEKKCEQTYVTWVEGEQQSVESGEEDEESNGEYPDDDEEYMDDMIDASTSQPINRVVEHFSEEPVFLHQ
Protein: Signal transducer and activator of transcription (E1U8C5)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MSLWGLVSKMPPEKLQRLYVDFPQHLRHLLGDWLENQPWEFLVGSDAFCCNMASALLSATVQRLQALAGEQGEGSTILQHISTLESIYQRDPLKLVATFRHILQGEKKAVMEQFRHLPMPFHWKQEELKFNTILRRLQHRVGETRLLRKALQPGAEAGQVSLHNLLETPAKGTGPSEALATLLQETVGELEAAQALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRAALISRLDEVLQTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSMPQGPGAGASESTGEIINNSVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFVLGPNKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPEPQMPTMVPTYDLGMAPDTSMNMQLSPDMVSQMYPPHSHSIPSYPAIPREESVSVLSAFQEPHLQMPPNLSQMGLPFDQPHPQGLLPCQPQEHAVSSPEPLLCPDVTMAEESCLSQPVGGFPQGTWVGEDMFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSLYGQSGISMSHLDLRANPSW
Protein: Zinc finger protein 580 (LDL-induced EC protein) (Q9UK33)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21599657}. Note=Colocalized with SMAD2 in the nucleus.
Interaction partners:
Sequence:
MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH
Protein: Scavenger receptor class B member 1 (SR-BI) (F5H4X0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004189}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004189}.
Interaction partners:
Sequence:
MWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGGL
Protein: Protein V2 (Q764F6)
Organism: Tomato yellow leaf curl virus-Mild [Japan:Atumi]
Subcellular location: Host cytoplasm, host perinuclear region {ECO:0000256|ARBA:ARBA00004407, ECO:0000256|RuleBase:RU364051}.
Interaction partners:
Sequence:
MWDPLLNEFPESVHGFRCMLAIKYLQSVEETYEPNTLGHDLIRDLISVVRARDYVEATRRYNHFHARLEGSPKAELRQPIQQPCCCPHCPRHKQATIMDVQAHVPEAQNIQNVSKP
Protein: Large ribosomal subunit protein eL29 (60S ribosomal protein L29) (L43) (Q24154)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein eL22
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL28
Sequence:
MAKSKNHTNHNQNKKAHRNGIKRPLRKRHESTLGMDVKFLINQRYARKGNLSREESVKRYNERIASQKGKPKPVTL
Protein: Flagellar regulator flk (Fluke) (P15286)
Organism: Escherichia coli (strain K12)
Function: Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity).
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sec-independent protein translocase protein TatB
- Sec-independent protein translocase protein TatC
- Sec-independent protein translocase protein TatA
- Sec-independent protein translocase protein TatE
Sequence:
MIQPISGPPPGQPPGQGDNLPSGTGNQPLSSQQRTSLESLMTKVTSLTQQQRAELWAGIRHDIGLSGDSPLLSRHFPAAEHNLAQRLLAAQKSHSARQLLAQLGEYLRLGNNRQAVTDYIRHNFGQTPLNQLSPEQLKTILTLLQEGKMVIPQPQQREATDRPLLPAEHNALKQLVTKLAAATGEPSKQIWQSMLELSGVKDGELIPAKLFNHLVTWLQARQTLSQQNTPTLESLQMTLKQPLDASELAALSAYIQQKYGLSAQSSLSSAQAEDILNQLYQRRVKGIDPRVMQPLLNPFPPMMDTLQNMATRPALWILLVAIILMLVWLVR
Protein: Unconventional myosin-VI (Unconventional myosin-6) (Q68RJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
Interaction partners:
Sequence:
MDDGKLVWAPHPTDGFQLGMIVDIGADALTIEPLHQRGKTFLAPISQVFPAEDDVNKHVEDNCSLMYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLPPHVYAIADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIFYRLCAGASEDIRNMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNXKSPEDHKHGKVGALKDPLLDDLGDFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEETGSTSGGCILKNQSSQTLEYCADLLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKRVNQCFPFDTSSNFIGVPDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGVNEVHYVDNQDCIDLVEAKLVGVLDILDEENRLPQPSDQHFAEAVHSKHKDHFRLTVPRKSKLTIHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRDLFENNSNSKDSKQKAGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPNKLTRLDPRLFCKALFKALGLNENDYKFGLTRVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKWLVCSRWKKVQWCTLSVIKLRNKMSYRASACIRIQKTVRMWLCRRRHKPRVDGLVKVKNLRKRMERFNEAVNGLKEGKAEMSKQIEELAASTDALMAKIKTTVMSRKEIEQEYEGLVKRSEQLLSSMQKKKQEQEETERLKHIQEZMEKERKRHEEEEQLRKQEEEDRRMKSEMEQKRKQEEEERKKREEEERVLQAELEMQLALDREEETQRQTILEQERRDRELAMRIAQNEAELIQDEAQMDPILRRDATTGVWFFTEMGAQVQANKVAAGVKKYDLSKWKYAELRDAINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTDTEMRAPKSVTDYAQQNPAPPVPARQQEIAMNRQQRYFRIPFIRPADQYKDPQNKKKGWWYAHFDGPWIARQMELHPDKQPILLVAGKDDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLKNAIESKQARPTYATAMLQNLLK
Protein: Secretory carrier-associated membrane protein (Secretory carrier membrane protein) (A0A140VK92)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363122}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363122}.
Interaction partners:
Sequence:
MSAFDTNPFADPVDVNPFQDPSVTQLTNAPQGGLAEFNPFSETNAATTVPVTQLPGSSQPAVLQPSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHSLAISVIMMVVAGFFTLCAVLSVFLLQRVHSLYRRTGASFQQAQEEFSQGIFSSRTFHRAASSAAQGAFQGN
Protein: Flavin-containing monooxygenase (EC 1.-.-.-) (Q9W1E9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- ATP synthase subunit alpha, mitochondrial
Sequence:
MMSVCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPKEVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKTKWQVLFKDLVTNKIEFQYFDKVLVANGHYHTPNYSQIPNMERFKGQFLHSHDFRSREVFEGKSVLVIGAGPSGMDLSNIISRTADRVTISHHLTDIGQHSFFENVQQKPDVRELDEKGAFFVDGSYQEFDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCINIRNPSMALIGLPFYVCAAQMMDIQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKRHAHMLGPKQIDYFTDLSQTAGVKNIKPVMTKLHNESSKCFNENLLHFREDNFAILDDETFIKLN
Protein: Ubiquitin-ribosomal protein eL40 fusion protein (Ubiquitin A-52 residue ribosomal protein fusion product 1) (Q3MIH3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK
Protein: Chromo domain-containing protein rhino (Heterochromatin protein 1) (Q7JXA8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000269|PubMed:19732946, ECO:0000269|PubMed:24906153, ECO:0000269|PubMed:25613572, ECO:0000269|PubMed:36193674}. Chromosome {ECO:0000269|PubMed:19732946, ECO:0000269|PubMed:24906153, ECO:0000269|PubMed:25613572, ECO:0000269|PubMed:36193674}. Note=Localizes to germline specific nuclear foci throughout oogenesis, which corelate with dual-strand piRNA source loci (PubMed:19732946, PubMed:24906153). All components of the Rhino-Deadlock-Cutoff (RDC) Complex associate with these nuclear foci and are required for their formation (PubMed:24906153). {ECO:0000269|PubMed:19732946, ECO:0000269|PubMed:24906153}.
Interaction partners:
- Protein deadlock
- Histone H3
- Histone H3.3A
- Moonshiner
- Protein piwi
- Protein aubergine
- Probable ATP-dependent RNA helicase spindle-E
- Probable RNA helicase armi
- Decapping and exoribonuclease protein Rai1
- Heterochromatin protein 1c
Sequence:
MSRNHQRPNLGLVDAPPNDHVEEYVVEKILGKRFVNGRPQVLVKWSGFPNENNTWEPLENVGNCMKLVSDFESEVFRLHRKAAAKSVGKSKSSPSSSGPLITENGPSSSKKTQQHSKSVQAKNTAGMSKMNQKKGKNIKKTAGKIKDIENYPKTQMPSTSQVSTDSTEVFDGNPSATTTNMIKSPRIQSLFSDLNLIEPTKDKDVGDTSLKTPPKSRRLIEFPQREDAPLSSKHVSPMLIRKESQPLQSSCTDDSDLGESSSSMSLPTVSSTSSEKSIKVTKSEPKTLGQIKFSSRSSDGGHAASSLGAPKEGDIGLDLSGSDSMDSEVESMRRCPRRKRKKTYPDWKFPEMTKPFGVNRGLDLDKILHCYQMNDDLFMFVTWKGCSSIDAVHINDIKEAYPLQIIKYFESLRIIVPK
Protein: Auxin response factor 11 (Q9ZPY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 2
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Anaphase-promoting complex subunit 6
Sequence:
MSQTSLEPLIISIIKLQILQLWLKLIAVGWNLGSNDDELYTELWKACAGPLVEVPRYGERVFYFPQGHMEQLVASTNQGVVDQEIPVFNLPPKILCRVLSVTLKAEHETDEVYAQITLQPEEDQSEPTSLDPPLVEPAKPTVDSFVKILTASDTSTHGGFSVLRKHATECLPSLDMTQPTPTQELVARDLHGYEWRFKHIFRGQPRRHLLTTGWSTFVTSKRLVAGDAFVFLRGETGDLRVGVRRLAKQQSTMPASVISSQSMRLGVLATASHAVTTTTIFVVFYKPRISQFIISVNKYMMAMKNGFSLGMRYRMRFEGEESPERIFTGTIIGSGDLSSQWPASKWRSLQIQWDEPSSIQRPNKVSPWEIEPFSPSALTPTPTQQQSKSKRSRPISEITGSPVASSFLSSFSQSHESNPSVKLLFQDPATERNSNKSVFSSGLQCKITEAPVTSSCRLFGFDLTSKPASATIPHDKQLISVDSNISDSTTKCQDPNSSNSPKEQKQQTSTRSRIKVQMQGTAVGRAVDLTLLRSYDELIKELEKMFEIEGELSPKDKWAIVFTDDEGDRMLVGDDPWNEFCKMAKKLFIYPSDEVKKMRSKSLLGDKGTIVNLESDQRTVHV
Protein: Small GTPase LIP1 (Protein LIGHT INSENSITIVE PERIOD 1) (Q9C5J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functional small GTPase that acts as a negative factor controlling the light-dependent period shortening of circadian rhythms and light-induced phase resetting during the subjective night. May protect the clock from excessive or mistimed light. Suppresses red and blue light-mediated photomorphogenesis and is required for light-controlled inhibition of endoreplication and tolerance to salt stress. The entrainment of the circadian clock is independent from the other pleiotropic effects. Could be a regulator of seedling establishment.
Subcellular location: Nucleus {ECO:0000269|PubMed:17683937, ECO:0000269|PubMed:23144185}. Cytoplasm {ECO:0000269|PubMed:17683937, ECO:0000269|PubMed:23144185}. Note=The localization is not affected by light, but the nuclear localization is essential for the circadian function. {ECO:0000269|PubMed:17683937, ECO:0000269|PubMed:23144185}.
Interaction partners:
- Triacylglycerol lipase 2
- Spen paralogue and orthologue SPOC C-terminal domain-containing protein
- Lipoyl synthase, mitochondrial
Sequence:
MKFWRERERENKEQILAPLCGQVRVLVVGDSGVGKTSLVHLINKGSSIVRPPQTIGCTVGVKHITYGSPASSSSSIQGDSERDFFVELWDVSGHERYKDCRSLFYSQINGVIFVHDLSQRRTKTSLQKWASEVAATGTFSAPLPSGGPGGLPVPYIVVGNKADIAAKEGTKGSSGNLVDAARHWVEKQGLLPSSSEDLPLFESFPGNGGLIAAAKETRYDKEALNKFFRMLIRRRYFSDELPAASPWSISPVPTSSSQRLDEITSDDDQFYKRTSFHGDPYKYNNTIPPLPAQRNLTPPPTLYPQQPVSTPDNYTIPRYSLSSVQETTNNGSARSKRMDINV
Protein: Urease accessory protein G (F4IHW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASHDHHHHHHDHEHDHDRKSDGGEGKASWVGKDGKVYHSHDGLAPHSHEPIYSPGYFSRRAPPLHDRNFSERAFTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGPLEELSNLFKADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDLAAAVGADLSVMERDSLRMRDGGPFVFAQVKHGLGVEEIVNHVMHSWEHATGKKRQ
Protein: Short chain dehydrogenase gsfE (EC 1.-.-.-) (Griseofulvin synthesis protein E) (D7PI19)
Organism: Penicillium aethiopicum
Function: Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units. The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone. However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C. Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B. The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin. Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin.
Interaction partners:
Sequence:
MPKTAFITGANGLSGSAIVEYLCNTTTSDDWGSIIVTSRSPFKSTVMDPRIKFIALDFVNDVSSLVETMKEVCGAVTHAYFCSYLHKDDFAESYTVNKALFENFIAAIDKAAPKLENVTLQTGGKYYNLHVEPVPSPARENDPRRYGPFENFYFTQEDTLAEMQRGKTWSWNVIRPEAIIGANSQPYGLNVALTIAMYFLICRELGSASPMPTNQRYWEGTDDVSYAPLIADLTIFVSTRKSCANEAFNVTNGDYFTWRYMWPRLAASLGAKADSQQCFEKPMPGEGELQLDWSLAEWCKDKRKVWEDLCDRQGLPGAKATFDLAGWAVGDFLYQRTWSATLSVNKARRFGWTGHMDSYQSFVDTFDKFRQLGLIPK
Protein: Protein SPA1-RELATED 4 (Q94BM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Repressor of photomorphogenesis in the light. Probably part of the COP1/SPA E3 ubiquitin-protein ligase complex.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- E3 ubiquitin-protein ligase COP1
- Cullin-4
- Phytochrome A
- Eukaryotic translation initiation factor 2 subunit alpha homolog
- Eukaryotic translation initiation factor 2 subunit alpha
- DNA damage-binding protein 1a
- WD-40 repeat-containing protein MSI3
- Protein SUPPRESSOR OF PHYA-105 1
- Protein SPA1-RELATED 2
- Transcription factor HY5
Sequence:
MKGSSESSSRGLNNTSGVSEFCTDGSKSLSHIDYVRSLLGSHKEANLGGLDDDSIVRALECEDVSLRQWLDNPDRSVDAFECFHVFRQIVEIVNAAHSQGIVVHNVRPSCFVMSSFNNVSFIESASCSDSGSDEDATTKSREIGSSRQEEILSERRSKQQEEVKKQPFPMKQILAMEMSWYTSHEEDNGSLCNCASDIYRLGVLLFELFCPVSSREEKSRTMSSLRHRVLPPQILLNWPKEASFCLWLLHPEPSCRPSMSELLQSEFINEPRENLEEREAAMELRDRIEEQELLLEFLFLIQQRKQEAADKLQDTISLLSSDIDQVVKRQLVLQQKGRDVRSFLASRKRIRQGAETTAAEEENDDNSIDEESKLDDTLESTLLESSRLMRNLKKLESVYFATRYRQIKAATAAEKPLARYYSALSCNGRSSEKSSMSQPSKDPINDSRQGGWIDPFLEGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARNQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSETGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHHKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSELEVDDASQFISSVCWRGQSSTLVAANSTGNIKILEMV
Protein: Potassium channel tetramerization domain containing 10 (F5GWK6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYEAQDGRGPDNALLEATGGAAGRSHHLDEDEERERIERVRRIH