wanglab/gogpt-training-data huggingface dataset:
Protein: F420-dependent hydroxymycolic acid dehydrogenase (fHMAD) (EC 1.1.98.-) (FGD2) (P96809)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making up the mycobacterial pseudo-outer membrane and over one-third of the dry weight of M.tuberculosis. Does not exhibit F420-dependent glucose-6-phosphate dehydrogenase (FGD) activity.
Subcellular location: Cell envelope {ECO:0000269|PubMed:23110042}. Note=The Rv0132c-F420 complex is translocated via the Tat pathway across the cytoplasmic membrane, where Rv0132c is anchored to the cell envelope. {ECO:0000269|PubMed:23110042}.
Interaction partners:
- Deazaflavin-dependent nitroreductase
- Bifunctional F420 biosynthesis protein FbiB
- Phosphoenolpyruvate transferase
- FO synthase
- Phosphoenolpyruvate guanylyltransferase
- Possible oxidoreductase
- Putative F420H
- Putative coenzyme F420-dependent oxidoreductase Rv3520c
- Probable acyl-CoA dehydrogenase FadE1
- F420H
Sequence:
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
Protein: Ribosomal protein eL22-like 1 (60S ribosomal protein L22-like 1) (Large ribosomal subunit protein eL22-like 1) (Q9D7S7)
Organism: Mus musculus (Mouse)
Interaction partners:
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL21
Sequence:
MAPQKDKKPKKSTWRFHLDLTHPVEDGIFDSGNFEQFLREKVKVNGKTGNLGNVVHIERLKNKITVVSEKQFSKRYLKYLTKKYLKKNNLRDWLRVVASDKETYELRYFQISQDEDGSESED
Protein: Scaffold protein OPG125 (62 kDa protein) (Rifampicin resistance protein) (P68440)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.
Subcellular location: Membrane; Peripheral membrane protein. Note=Associates transitorily with crescent and IV membranes.
Interaction partners:
Sequence:
MNNTIINSLIGGDDSIKRSNVFAVDSQIPTLYMPQYISLSGVMTNDGPDNQAIASFEIRDQYITALNHLVLSLELPEVKGMGRFGYVPYVGYKCINHVSISSCNGVIWEIEGEELYNNCINNTIALKHSGYSSELNDISIGLTPNDTIKEPSTVYVYIKTPFDVEDTFSSLKLSDSKITVTVTFNPVSDIVIRDSSFDFETFNKEFVYVPELSFIGYMVKNVQIKPSFIEKPRRVIGQINQPTATVTEVHAATSLSVYTKPYYGNTDNKFISYPGYSQDEKDYIDAYVSRLLDDLVIVSDGPPTGYPESAEIVEVPEDGIVSIQDADVYVKIDNVPDNMSVYLHTNLLMFGTRKNSFIYNISKKFSAITGTYSDATKRTIFAHISHSINIIDTSIPVSLWTSQRNVYNGDNRSAESKAKDLFINDPFIKGIDFKNKTDIISRLEVRFGNDVLYSENGPISRIYNELLTKSNNGTRTLTFNFTPKIFFRPTTITANVSRGKDKLSVRVVYSTMDVNHPIYYVQKQLVVVCNDLYKVSYDQGVSITKIMGDNN
Protein: ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1) (A4IG62)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}.
Interaction partners:
- DIS3-like exonuclease 1
- DIS3-like exonuclease 2
- Exosome complex exonuclease RRP44
- Zinc phosphodiesterase ELAC protein 2
- RNA helicase.
- Fucosyltransferase
- Activating signal cointegrator 1 complex subunit 1.
- Karyopherin alpha 1
- ATP-dependent DNA helicase PIF1
- Eukaryotic initiation factor 4A-III
Sequence:
MSVNRCIYLLSRSHIRYRVCASTNLSTVSTLSTTQHSTRRTFDKLSTRHSSSGSSRPLDTSLFIPLPVKTDEDAEGSVGAELTKPLDKNELLKVLNRFYKRKEMQKLASDQGLDARLFHQAFVSFRKYVLEMNSLNADLHIILNDICCGAGHIDDIFPYFMRHAKQIFPMLDCIDDLRKISDLRVPANWYPEARAIQRKIVFHAGPTNSGKTYHAIKRYLEAKSGVYCGPLKLLAHEIYEKSNAAGVPCDLVTGEERIFVDPEGKPSGHIASTIEMCSVTTPYEVAVIDEIQMIKDPARGWAWTRALLGLCAEEIHVCGEAAAVDFITELMFTTGEEVEVHNYKRLTPFSISNHAVESLDNLKPGDCIVCFSKNDIYSISRQIEIRGLECAVIYGSLPPGTKLAQAKKFNDPDDPCKILVATDAIGMGLNLSIRRIIFNSLVKHSLNEKGEKEVDTISTSQALQIAGRAGRFSSVFKEGEVTTMHRDDLPVLKEILGKPVDPIATAGLHPTAEQIEMFAYHLPQATLSNLIDIFVSLSQVDGLYFVCNIDDFKFLADMIQHIPLNLRSRYVFCTAPINKKQPFVCTSFLKFARQFSRDEPLTFNWVCRQVNWPLSPPKNIKDLVHLEAVHDVLDLYLWLSYRFMDMFPDSNQIREIQKELDENIQIGVRNITRLIRAIDSQPTDTESNSSSTVPESETSQRKGRVLRSQNQRKELPRKSSLSSRLLRDGLLTKELLSQLQKEWAREQNEDNSIPVNNGKRKKK
Protein: Cephalosporin-C deacetylase (EC 3.1.1.41) (Acetylxylan esterase) (EC 3.1.1.72) (Q9WXT2)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Esterase that removes acetyl groups from a number of O-acetylated small substrates, such as acetylated xylose, short xylo-oligosaccharides and cephalosporin C. Has no activity towards polymeric acetylated xylan, 4-methylumbelliferyl acetate or alpha-naphthyl acetate. Able to catalyze rapid hydrolysis of a range of substrates preferably with acetate groups, independent of the alcohol moiety. Exhibits a narrow selectivity for short chain acyl esters (C2-C3). Displays broad substrate specificity by hydrolyzing acetate at 2, 3, and 4 positions of 4-nitrophenyl-beta-D-xylopyranoside (pNP-Xyl) with similar efficiency. Cannot cleave amide linkages.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P94388}.
Interaction partners:
- Xylosidase
- Oligopeptide ABC transporter, ATP-binding protein
- Oligopeptide ABC transporter, ATP-binding protein
- Oligopeptide ABC transporter, permease protein
Sequence:
MAFFDLPLEELKKYRPERYEEKDFDEFWEETLAESEKFPLDPVFERMESHLKTVEAYDVTFSGYRGQRIKGWLLVPKLEEEKLPCVVQYIGYNGGRGFPHDWLFWPSMGYICFVMDTRGQGSGWLKGDTPDYPEGPVDPQYPGFMTRGILDPRTYYYRRVFTDAVRAVEAAASFPQVDQERIVIAGGSQGGGIALAVSALSKKAKALLCDVPFLCHFRRAVQLVDTHPYAEITNFLKTHRDKEEIVFRTLSYFDGVNFAARAKIPALFSVGLMDNICPPSTVFAAYNYYAGPKEIRIYPYNNHEGGGSFQAVEQVKFLKKLFEKG
Protein: Titin (A0A8I5ZX32)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTTQAPTFTQPLQSVVVLEGSAATFEAHISGSPVPEVSWFRDGQVISTSTLPGVQISFSDGRARLMIPAVTKANSGRYSLRATNGSGQATSTAELLVTAETAPPNFSQRLQSMTVRQGSQARLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTADLLVQGEEVVPAKKTKTIVSTAQISETRQTRTEKKIEAHFDARSIATVEMVIDGATGQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAGRISTSPIRSVKSPLLIRKTQTTTVATGPEVPPPWKQEGYVASSTEAEMRETTMTSSTQIRREERWEGRYGVQEQVTISGAAGTAASVSARSSFTAEAVTTGAKEVKQETDKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHVQPAQKQMRKEAEKTAVTKVVVAADKAKEQELRLRTREEIITKQEQTHIAHEQIRKETEKAFVPKVVISATKAKEQETRITGEITTKQEQKRITQETVGVGKKAEAVATVVAAVDQARVREPREPRHVEESYSQQTTLEYGYKEHISATKVPEQPQRPASEPHVVPKAVKPVVIQAPSETHIKATDQVGMHISSQVKKTTDISTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAIATLQKELSTTSSTQKITKSVKAPTVKPGETRVRAEPTPSPKFPFADVPAPDTYKSQAGIEVKKEVGVSISGSTVREEQFELLRGREAKVTETARVPAPAEVPVTPPTLVSGLKNVTVVEGESVTLECHISGYPSPKVTWYREDYQIESSIDFQITFQSGIARLMIR
Protein: Ran GTPase activating protein 1 (H0Y4Q3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASL
Protein: Altered inheritance of mitochondria protein 24, mitochondrial (Found in mitochondrial proteome protein 26) (P47127)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}.
Interaction partners:
- MICOS complex subunit MIC60
- MICOS complex subunit MIC12
- MICOS complex subunit MIC10
- Altered inheritance of mitochondria protein 34
Sequence:
MISPRVNTRVWQRSISLLSPQAAKTESNVVTKERTYIENLSKDIATSRFRLVDENGKIASITVQPDIPICIKKDCLVSIHNLNHLSLSYKWLNFWSNLIKFRSFKSSLFHRIIGSSVLEILAAPNFQTSRRPFDSSRSLSVLNLTGTKDWNVFGKDSIIAFEQNSSLEIKSPIFPSARSLVSNSSKSQLPRKFQILNGRGNVLVCGGGLVYSIELIDESDKILVNSRNILAINGQSQLDIANSVERQELHVEGAYVGDSSNDTVAPKFIKNQTLKSAYGHTVQFFKRMRSWIRNQYEKRYIYGVDSYFMKIKGPRTILIQTHEMTTSKDNILTKLTSKGHVKKSNVNDNGVNLEKQVANDVNSKIIELANRPSLFIATVSQDGRVDFQSTSKFT
Protein: Integrator complex subunit 4 (Q9W3E1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Essential for development. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:39032490}.
Interaction partners:
- Integrator complex subunit 3
- Integrator complex subunit 11
- Integrator complex subunit 5
- Integrator complex subunit 9
- Integrator complex subunit 1
- Integrator complex subunit 7
- Integrator complex subunit 2
- Integrator complex subunit 6
- Integrator complex subunit 12
- Integrator complex subunit 10
Sequence:
MALAIKKRVGTYVETVDGSPPVKKLRLQTLAADAKGGKSGKVGNVERKLTALNQLDAYVGNLPAGALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEMGELKEVASKIFQLYQLQERDSDTSIRVKLLELLSGLGCECATEQALTMIIDYFIFLLRKEVSQKVLAQGMMCLFRIGERRKHMLPISYKTQVAHLAKEQLRSGSAHTQKNAMLVIGRFATKMEGERHYVWKLAFYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAMKDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSKVCEALCDLSLQIRVLAAELLGGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSGKRWADDAPQEHLDAQSISIIASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFLVDMFNDEIEDVRLKAIYSLTAIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTCLLMVVQKLLDVLAKYPQDRNSTYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLCVLILVFNAAEHLVPIISLLPTATHRHYAYLRDSMPNLVPQLPIEGASSASATHRIDSAMHQAGSSAEYLQMILSHIEEIFTMTDERLELLQTAQSNLQRLGSIDAGMYGTSNFLETFLAAQIQIEQMQRCASTQRSRVPLKESLAALIRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVRDRSQSALGPCQMLLQTAGDISEFIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREILPLVQQAPPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADMRIKIKYPDQHMHTVVPKQSDFKPIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEIQLCLAVRPGSELELCKPAKVLFAPKPVRRGI
Protein: D-lactate dehydrogenase (EC 1.1.99.6) (O29853)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Function: Catalyzes the dehydrogenation of (R)-lactate (D-lactate) to pyruvate. Is likely involved in the utilization of D-lactate as a sole source for both carbon and electrons for dissimilatory sulfate reduction. Cannot use L-lactate as substrate, and NAD(+), horse cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. Active in vitro with artificial electron acceptors such as 2,6-dichlorophenolindophenol (DCPIP); the physiological acceptor is not known, but potential acceptors include cytochromes or quinones.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15803647}; Multi-pass membrane protein {ECO:0000303|PubMed:15803647}. Note=Extracellular part of the protein faces the S-layer. {ECO:0000269|PubMed:15803647}.
Interaction partners:
- NADH oxidase
- L-lactate dehydrogenase, cytochrome-type
- Electron transfer flavoprotein, subunit alpha
- Electron transfer flavoprotein, subunit beta
- Cytochrome C oxidase, subunit II, putative
- ABC transporter, ATP-binding protein
- Isopentenyl-diphosphate delta-isomerase
- Uncharacterized protein
- ABC transporter permease
Sequence:
MSWIDELSKIVEVFPPSDAYRFDETPPLVAPRAAENFVVVKPSNSEEVSAILKFANEKSIPVFMRGGGTGLSGGAVPTEEGIVLSTEKMTELEVDADNRVAICGAGVTLKQLDDAAFRHGLSFPPHPGAETATVGGMIATNAGGVRALKYGTMRNYVLSLEAVLADGRIINVGGKTIKNSSGYSLLHLLVGSEGTLAVITKATIRLFPQMRDMTVLAIPFPTMEDAMNCVVEVARKMLPMALEFMEKRAVEIGEKVSGERWVSREGEAHLLMVFESFDEAEEAAKIAQSLGAIDVYAATTKKDQDRLLKVRGMIYEGLRKEVIEVLDACVPPAKIAEYWRRSNELAEEYGIELITYGHAGDGNVHQHPLVYEGWEKSYFEFRKSLLSLAVSLGGVISGEHGIGAVKLSELEELFPEQFELMRQIKLLFDPKNILNPGKVVRKL
Protein: Rho family GTPase (A0A1D8PH96)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Rga2p
- Lrg1p
- Exocyst complex protein EXO70
- Protein kinase C-like 1
- Exocyst complex component Sec8
- Formin BNI1
- Rgd1p
- Exocyst complex component SEC15
- Rho GDP-dissociation inhibitor
- Exocyst subunit
Sequence:
MPLCGGGQKTIQRKIVILGDGACGKTSLLNVFTRGYFPQVYEPTVFENYVHDIFIDGQSVQLSLWDTAGQEEFDRLRSLSYSDTHCIMLCFSVDSPDSLENVQSKWVGEIADHCEGVKLVLVALKCDLRNNEDIEDQQQSNPYSSQKRLITYEEGLAVAKKVGALRYLECSAKKNKGVNEAFSEAARCALNAKPKGANDNEPQKKGCVVM
Protein: Myosin binding subunit, isoform K (Q9VUX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSLDARNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAASGSSEATEANSSIPNAAADDNNDDDGHDDVGGGGEVMASGQSDTEELSDSTESSHLTSLSESEAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKKPTVTIATSTAATAINSPSTTVQTPPIRRSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFANAQLDAYKSDNHRLKEENAALIRVISKLSK
Protein: Transmembrane protein 43 homolog (Q9VSB9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:35869176}; Multi-pass membrane protein {ECO:0000269|PubMed:35869176}. Nucleus envelope {ECO:0000269|PubMed:35869176}.
Interaction partners:
Sequence:
MASLSETLRSHWPIALFGVILFVAGGTELYWNEGRAVHNMMALDEAHADIYSVRFTEEEQEVGLEGRIVHLSGPILVGEPLTEPDYNIQLLAVKLRRRVQMYQWVEEAVEHNYGDSVGTTHSDSRTYYYTREWRDKIVDSRNFYNRHGHTNPSHFPIESHVQVADAVFIGRYELGAEVKEKFNNYQELTSDIRPEDSGVKLHLGIYYHTNDVFNPEVGDLRLLFSFAGMEGEVFSVVGKLSGNKLVPYITSRGVPVLLVYPGGLSVQEVFRLEARAQVLHTWWWRFVGWLLIFFGVTCNTKILRLLFVRVPLLVALAPDPQFPVTGNLLIAFSLALTIAAVAWILHRPVIGACLLLAGASPYVWFTRNLVDYHRLD
Protein: Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K) (P68978)
Organism: Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Function: Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).
Subcellular location: Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MRYMILGLLALAAVCSAAKKVEFKEPACNVTFKSEANECTTLIKCTTEHEKLIIRHKDKIGKYAVYAIWQPGDTNDYNVTVFQGENRKTFMYKFPFYEMCDITMYMSKQYKLWPPQKCLENTGTFCSTALLITALALVCTLLYLKYKSRRSFIDEKKMP
Protein: Stathmin, isoform B (Stathmin, isoform E) (Q8IPK0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLIGLVRDSVMQCFCHTCRAPGILPAVSRRSAPIKKNNKIRSKQPRLSKKVKFITTEIRCQEKSRGGLSYEVILAEPAPNVAVPKRPVTPGKNVSVEEIEQKLKAAEERRISLEAKKMADISTKLAKVEEATRKKDEITNEFITQTKEQLESKMELHVEKREAIISDMKEKLKIHAQDIEKTRETLEQQKANEQKAIEEKLKIAQSLRDENIKKMLDRLKEHNTIKIAEIKSQNDQLECQKIEEKARIYENKLFAAEQKREKELQKKIEKVQKLERRAELVRQNKAQAQDLDGQQSAIASSG
Protein: 40S ribosomal protein S23, putative (Q38CD1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal protein L19, putative
- Large ribosomal subunit protein eL18
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L39, putative
- Polyubiquitin, putative
- 40S ribosomal protein S18, putative
- 40S ribosomal protein S8
- 40S ribosomal protein S16, putative
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S26
Sequence:
MTKTNGQHAARKLVRLRRKNRWADKGWKKSHTFVAQKANPFGGSSHAKGIVLEKIGVGAKQPNSAIRKCVRVQLIKNDKKIIAFVPNDGCLHFIEENDEVLVSGFGRSGHAVGDIPGVRFKIVKVSSVGLYALYRQKKEKPRN
Protein: Protein SBE2 (Suppressor of BEM4 protein 2) (P42223)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: With SBE22, is involved in cell wall integrity and polarity processes like bud growth, through the transport of CHS3 and UTR2 to sites of growth.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:10679005}.
Interaction partners:
- Uncharacterized protein YKR045C
Sequence:
MTARRLINIVPNTSKLDPLKEEDSTHLKQNQPKKFSTKELMLSEYTERKSCSLPLSKSRSGSSASSSTTGSNGKNIGTRRPSSNLDFNFASQDVVKNVLGNNNPHVPTAKCIRPISDDSIGTSSTEIFSSSHSNTTSDSLCTSDISSEEGEIANSKMEDNCFFKSMREADHRSNITPLKKSRPGSILQKTRTASSADKTICSMSTITTCIPSRQNSVSTPKLSRTVGLPGSSNTTNSIAASQTSFISENDSPLKHHCMSTATIQEPKLMPITKTPYVHSNSTSVILPYKTTQLTPSQRYRLRKEQNDQSLRKAIKMKEKFYEDQDVNLELQEGDVDGSLIWNIPMASLSTSSFLTLSKFNRKEMSLDSARGDEEILIQENNCEGKQHSSSALCVDKTFHQVHSTRKHTSNSSNTLKESCLDYKELPPTCIPGISPVSDSQYIQDTMKNLSQIYLHSSEKISKSILSGRSRSVQSLPLEFKEASSQGMEDLMLVSEDKLKAVSHFRPSWLPPKDFKERKLQDKQIYKNIDLASMEELQKNKERDEKAKKNEQNKVKFQHLLDRGITRNSSLSELKKIIWETPLISKVRLQIYSQLLQSDNCLITKCFIESFEEVMQLLNKMDFPKDKEFEIRQLIEHDVQEKVFYKNGTDKQVVSDLMLLLQLKSISQQGLVTGDEMLFYHFLTDQSFGTLKETWEMVNLIQMTCFSEICKEKYDSRILNPRGIVAHLLRKDEFKNEFNGGCLNSNTWWNILQRMDHKLFMWVMDVIIVHNGQNFANYPVKMEIFKDKVWEYYRSKKVIVNYKILVSLTVNVLLNYHFGYDNLKHLSDLDDKHFCIPLYTEDSIEEENLNNIFTKWWLHYYRKLR
Protein: Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) (Q15375)
Organism: Homo sapiens (Human)
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Ephrin-A5
- Ephrin-A2
- Ephrin-A3
- Ephrin-A1
- Ephrin-A4
- Tyrosine-protein kinase ABL1
- Ephexin-1
- Ephrin type-A receptor 3
- Ras GTPase-activating protein 1
- Ephrin-B2
Sequence:
MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
Protein: Fumarate reductase subunit C (Fumarate reductase 15 kDa hydrophobic protein) (Quinol-fumarate reductase subunit C) (QFR subunit C) (P0A8Q0)
Organism: Escherichia coli (strain K12)
Function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones. The QFR enzyme complex binds 2 quinones in or near the membrane; 1 near the [3Fe-4S] cluster (QP is proximal to the [3Fe-4S] cluster, on the cytoplasmic side of the membrane) while QD (the distal cluster) is on the other side of the membrane. It is not clear if both of the quinol-binding sites are functionally relevant.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00708, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00708, ECO:0000269|PubMed:10373108}.
Interaction partners:
- Fumarate reductase subunit D
- Fumarate reductase flavoprotein subunit
- Fumarate reductase iron-sulfur subunit
- Succinate dehydrogenase flavoprotein subunit
- Succinate dehydrogenase cytochrome b556 subunit
- Succinate dehydrogenase iron-sulfur subunit
- Succinate dehydrogenase hydrophobic membrane anchor subunit
- Succinate--CoA ligase subunit alpha
- Succinate--CoA ligase subunit beta
- Succinate-semialdehyde dehydrogenase [NADP
Sequence:
MTTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVATIVILFVALYW
Protein: Meiotically up-regulated protein C1442.13c (Meiotic chromosome segregation protein C1442.13c) (O94585)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis and sporulation. Required for meiotic chromosome segregation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43
- Squalene synthase
- Protein pxr1
- U3 small nucleolar RNA-associated protein 25
- Uncharacterized protein C13G1.09
- U3 small nucleolar RNA-associated protein 22
- ATP-dependent RNA helicase dbp4
- Probable ATP-dependent RNA helicase prh1
- Probable nucleolar complex protein 14
- Uncharacterized protein C3B8.09
Sequence:
MAIIVEDGSFITSSQWENVEASPKPPPRKPKIVQPKKKPSKHLSNEDALEKYEMLFGERRKEVELDYMSHIAEEETSLSMIEYDRHFALQTDVKLSKKRKSKLVEMTPKGLKKRKRVQIQEGSVSTNTKKRMDGHVVGSSAPAINNGKGKQLLEMMGWSRGKGLGSENQGMVDPVVAVVKNNKQGLH