Protein: ABC transporter G family member 37 (ABC transporter ABCG.37) (AtABCG37) (Pleiotropic drug resistance protein 9) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 4) (Protein POLAR AUXIN TRANSPORT INHIBITOR SENSITIVE 1) (Q9LFH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with ABCG36, regulates auxin homeostasis and responses by playing a dual role in coumarine (and derivatives) and in the auxin precursor indole 3-butyric acid (IBA) efflux transport, thus influencing roots and root hairs development. Mediates coumarin exudation in the rhizosphere, especially in iron (Fe) deficient conditions, with a strong specificity for highly oxygenated compounds such as scopoletin and derivatives, dihydroxyscopoletin, esculetin, fraxin, fraxetin and esculin; these molecules improve plant Fe nutrition. Involved in the cellular detoxification of xenobiotics by promoting the excretion of some auxinic herbicides including 2,4-dichlorophenoxyacetic acid (2,4-D), 4-(2,4-dichlorophenoxy)butyric acid (2,4-DB) and other members of the phenoxyalkanoic acid family as well as the polar auxin transport inhibitor, napthylphthalamic acid (NPA). May be a general defense protein (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16877699, ECO:0000269|PubMed:20451385, ECO:0000269|PubMed:20498067}; Multi-pass membrane protein {ECO:0000255}. Note=Polarized localization at the outermost side of root epidermal and cap cells. {ECO:0000269|PubMed:20451385, ECO:0000269|PubMed:20498067}.
Interaction partners:
- Feruloyl CoA ortho-hydroxylase 1
- Fe
- Ferric reduction oxidase 2
- Beta-glucosidase 42
- Scopoletin 8-hydroxylase
- Xanthotoxin 5-hydroxylase CYP82C4
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Transcription factor MYB72
- ATPase 2, plasma membrane-type
- Protein DETOXIFICATION 43
Sequence:
MAHMVGADDIESLRVELAEIGRSIRSSFRRHTSSFRSSSSIYEVENDGDVNDHDAEYALQWAEIERLPTVKRMRSTLLDDGDESMTEKGRRVVDVTKLGAVERHLMIEKLIKHIENDNLKLLKKIRRRIDRVGMELPTIEVRYESLKVVAECEVVEGKALPTLWNTAKRVLSELVKLTGAKTHEAKINIINDVNGIIKPGRLTLLLGPPSCGKTTLLKALSGNLENNLKCSGEISYNGHRLDEFVPQKTSAYISQYDLHIAEMTVRETVDFSARCQGVGSRTDIMMEVSKREKEKGIIPDTEVDAYMKAISVEGLQRSLQTDYILKILGLDICAEILIGDVMRRGISGGQKKRLTTAEMIVGPTKALFMDEITNGLDSSTAFQIVKSLQQFAHISSATVLVSLLQPAPESYDLFDDIMLMAKGRIVYHGPRGEVLNFFEDCGFRCPERKGVADFLQEVISKKDQAQYWWHEDLPYSFVSVEMLSKKFKDLSIGKKIEDTLSKPYDRSKSHKDALSFSVYSLPNWELFIACISREYLLMKRNYFVYIFKTAQLVMAAFITMTVFIRTRMGIDIIHGNSYMSALFFALIILLVDGFPELSMTAQRLAVFYKQKQLCFYPAWAYAIPATVLKVPLSFFESLVWTCLSYYVIGYTPEASRFFKQFILLFAVHFTSISMFRCLAAIFQTVVASITAGSFGILFTFVFAGFVIPPPSMPAWLKWGFWANPLSYGEIGLSVNEFLAPRWNQMQPNNFTLGRTILQTRGMDYNGYMYWVSLCALLGFTVLFNIIFTLALTFLKSPTSSRAMISQDKLSELQGTEKSTEDSSVRKKTTDSPVKTEEEDKMVLPFKPLTVTFQDLNYFVDMPVEMRDQGYDQKKLQLLSDITGAFRPGILTALMGVSGAGKTTLLDVLAGRKTSGYIEGDIRISGFPKVQETFARVSGYCEQTDIHSPNITVEESVIYSAWLRLAPEIDATTKTKFVKQVLETIELDEIKDSLVGVTGVSGLSTEQRKRLTIAVELVANPSIIFMDEPTTGLDARAAAIVMRAVKNVADTGRTIVCTIHQPSIDIFEAFDELVLLKRGGRMIYTGPLGQHSRHIIEYFESVPEIPKIKDNHNPATWMLDVSSQSVEIELGVDFAKIYHDSALYKRNSELVKQLSQPDSGSSDIQFKRTFAQSWWGQFKSILWKMNLSYWRSPSYNLMRMMHTLVSSLIFGALFWKQGQNLDTQQSMFTVFGAIYGLVLFLGINNCASALQYFETERNVMYRERFAGMYSATAYALGQVVTEIPYIFIQAAEFVIVTYPMIGFYPSAYKVFWSLYSMFCSLLTFNYLAMFLVSITPNFMVAAILQSLFYVGFNLFSGFLIPQTQVPGWWIWLYYLTPTSWTLNGFISSQYGDIHEEINVFGQSTTVARFLKDYFGFHHDLLAVTAVVQIAFPIALASMFAFFVGKLNFQRR