wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquitin-conjugating enzyme E2-34 kDa (EC 2.3.2.23) (Cell division control protein 34) (E2 ubiquitin-conjugating enzyme 3) (E3 ubiquitin ligase complex SCF subunit CDC34) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (P14682)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ubiquitin-activating enzyme E1 1
- Cell division control protein 53
- Suppressor of kinetochore protein 1
- RING-box protein HRT1
- Cell division control protein 4
- Polyubiquitin
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40A fusion protein
- NEDD8-like protein RUB1
- F-box protein MET30 subunit MET30)
Sequence:
MSSRKSTASSLLLRQYRELTDPKKAIPSFHIELEDDSNIFTWNIGVMVLNEDSIYHGGFFKAQMRFPEDFPFSPPQFRFTPAIYHPNVYRDGRLCISILHQSGDPMTDEPDAETWSPVQTVESVLISIVSLLEDPNINSPANVDAAVDYRKNPEQYKQRVKMEVERSKQDIPKGFIMPTSESAYISQSKLDEPESNKDMADNFWYDSDLDDDENGSVILQDDDYDDGNNHIPFEDDDVYNYNDNDDDDERIEFEDDDDDDDDSIDNDSVMDRKQPHKAEDESEDVEDVERVSKKI
Protein: Alpha/beta-Hydrolases superfamily protein (At3g47590) (Q9SN79)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRTLLHNFNFVPQDSPYYKTSPFPTSSFFNVRFPIKNNQISCNKAKNLRMDPSKGIQEQRIVIPNRHNEKLVGLLHETGSTDIVVLCHGFRSNKSNQIMNNVAAAIQKEGISAFRFDFSGNGESEGSFYYGNYNHEADDLHSVVQYFSNKNRVVPIILGHSKGGDVVLLYASKYHDVRNVINLSGRYDLKKGIRERLGEDFLERIKQQGFIDVGDGKSGYRVTEKSLMDRLSTDIHEACLKIDKECRVLTVHGSEDEVIPVEDAKEFAKIIPNHKLEIVEGANHGYTEHQSQLVSTVMEFIKTVIVKNN
Protein: B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) (Q9BQE9)
Organism: Homo sapiens (Human)
Function: Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression (By similarity).
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- AT-rich interactive domain-containing protein 1A
- B-cell CLL/lymphoma 7 protein family member C
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Protein SSXT
- SWI/SNF complex subunit SMARCC2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- AT-rich interactive domain-containing protein 1B
Sequence:
MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTASES
Protein: Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1) (P70562)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator
- Myoblast determination protein 1
- Circadian locomoter output cycles protein kaput
- DNA-binding protein inhibitor ID-2
Sequence:
MKTKNRPPRRRTPMQDAEATPGEQTPDRSQSGSGASEVTKGLRSRTARASGTRAEVSRRRQGSSSRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAVLGVTEDQPQGHLQRYSTQIHSFREGS
Protein: Cell fusion protein aff-1 (Anchor cell fusion failure protein 1) (G5EGL9)
Organism: Caenorhabditis elegans
Function: Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17488621}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:21350017}.
Interaction partners:
- Fatty acid synthase
- Protein ver-1
- Bifunctional glyoxylate cycle protein
- Zinc finger protein ztf-16
Sequence:
MRLWQWSIAVAICLVMVTEARLRRHHRKRRFVSSNFDEFYCGESAHAQSQFEEERESNSSKVSSVHSTQFNWGLDNTICIKLQNVVHVLKYERLEQRYPIENSYTFSVPLIDTNCKCHCYGFGTNDVCNVEKYADDRNCTTSSEFPTCYTKYHPAVEPLDCPVTSIPAKACCDIKLKPRDGRMFRAVKLQQPINDMIISHSIFANNSGKMMKVLGPDEFRINLLKGKEQFELTEYHRISVQLVASSPQQQLREGMYYFPEENHNDLREGKINEITESDLDKLGWYRRVGNDWQVATSGLLLRNAHKVVIKNCKGQVHMDQFSGTKNFVLRGTQYNDTYNERRVSDNNFVRSVKVDESSREITIVHEHGTAAQVSLKTDTRPNLTKSQSLLANFTGSITLDHDGNRMLNVTFFGVKGTVHIKMYVNDRKLIATFACTAQFGTSLKDDGSRISLPSTINQAQWVCILPDEQPTKSEICKWIPYEEKAMRTPRQEQSWSKGHSPCSQAECNSLKSGVSDLFPWIMNFDYFMAHGGDFTEWLKIGIHIVIAVGLLLLLILLFTKCLVPLACCSLSIPFKNRNKKKKKKNSSDY
Protein: EF-hand domain-containing protein (Q382T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTSVKETKEPKPSINRARDLPWWKRLVLDPSYRKRVRRIATECYRKEMSVVRDFPEKLFSAEREYGVPLVSSSQYVQLEGESKWATRHPSTIMKTSSLKTLRDSATTTVLPVFGQDHESRVDDEIKRLFQQEKADNRLYGLSYIWDEQLPPMGFIRQWPPPHQGMWPTGCVHRQLQKVQLPSDRKAREALAHNPLFVHIYRQGGEFLGVWRQSLLLLRYKIICCALHEEALGSRNPNGEKKSSTRRAHLMYVPEFTSPLLRLQGDTTVSVMEGRVNVETISPPTTWEGLAPSPSKVHVDQGYLNWCAFHNSSPMVRQSVRDVYNMLPHDEDGRLTKDVFVEFVLDLLNLFFPLNNSASNIAIAEEEWAFRGTSELVSFDTFFEKFFSFPFIFLRNFEEVTRDMYVEVWCLIRICLLETEHTIHSSSRGITTNVTEVLKQRLEQDYEQTATRTLHRIPKQRSFTLNGGNSNANLDFQMVPKPKIAPLHSKGRPPPQQPRDIPALISGINGFTAEDVINLGCTDFHNTDNYKTYAMKRRILEECEDAPYKIPSSRQVLFAHKKAERLLAEDREANQLESPQIFLEVEEANDSLGTYVLGSPSSSTTGSVKSHNNRMESMKKRRDALEELENRHTIEKLLATSYWYRRRRQQRKKALNDAHTLVSRCHTSWEMFQYDVYEIPEENPTEVDDLIAFVLDLPDDFFVVDTSLRMRNTVYRVHESVRESRLPKVRKVDELQLFEERIKKEAESLWRERLYGTEKQSVKEGDSEAAQPEGSSTTVDDEVPPRLPAKSNVVYQPQVWSLTELSQATTRRNWSVASALKCAVKVPSTAGHNGFS
Protein: RNA helicase (EC 3.6.4.13) (O44781)
Organism: Caenorhabditis elegans
Interaction partners:
- RNA-binding protein rnp-4
- Protein mago nashi homolog
- Pre-mRNA-splicing factor CWC22 homolog
- Protein CASC3
- RRM domain-containing protein
- MI domain-containing protein
- Serine/threonine-protein kinase smg-1
- LiPid Depleted
- UPF3 domain-containing protein
- RNA helicase
Sequence:
MAGKKAEKDDMATVEFESSEEVNVIPTFDKMGLREDLLRGIYAYGFEKPSAIQQRAVPAILKARDVIAQAQSGTGKTATFSISVLQSLDTQVRETQALILSPTRELAVQIQKVVLALGDYMNVQCHACIGGTNLGEDIRKLDYGQHVVSGTPGRVFDMIRRRNLRTRAIKLLVLDEADEMLNKGFKEQLYDIYRYLPPGAQVVLLSATLPHEILEMTSKFMTDPIRILVKRDELTLEGIKQFFVAVDREEWKFDTLIDLYDTLTITQAVLFCNTRRKVDWLTDKMKEANFTVSSMHGDMEQKDRDEVMKEFRAGTTRVLISTDVWARGLDVPQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVAINFVKQDDVRILRDIEQYYSTQIDEMPMNIADII
Protein: UPF0494 membrane protein C750.06c (Q9P3E5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Vacuole {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSNPESLKKQVEPPGYNELFMVEDVCNVDLEQGLDLCKPEKVNKQSQRSRQSRQSLFTNTIKPQKDKMNIKTNKIKEFLNDPFTEFSKFHNSYYPDGRISTRSNFRWPLLIIWSIIIVFAVDKKFEVQKFLSIWINENRFYSEIWVPIAIYVCLLVLMLLSLIFFAEFAVLALRVTGVIIAVLGAVLGMIIAVLGMIIAALGMIIAALGATITGLLYFGHWALYKLVILSLGFKIVTPGDVCVSNTLPTHNGETALHSETTVGSDIEQIELQNMPTPVKK
Protein: AT4g31560 (High chlorophyll fluorescence 153) (Q9SV14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Beta-1,3-N-Acetylglucosaminyltransferase family protein
- Thioredoxin-like protein HCF164, chloroplastic
- Cytochrome c-type biogenesis ccda-like chloroplastic protein
- Thiol-disulfide oxidoreductase LTO1
- Aspartate--tRNA ligase 2, cytoplasmic
- At4g26980
- Protein SNOWY COTYLEDON 3
- Aspartate--tRNA ligase 1, cytoplasmic
- Cytochrome c6, chloroplastic
Sequence:
MARLFVSIPMQPTQISFPASSSQPLLSPPANNFTDGGAGGLCLTRRIRDSSVVTRAGPSTSSYLLAFAIPATLIAATVFTSIKIADKLDEDFLEDIALNQAIKAAEKGENGEGDISLDDVIQEPVLQRTRNRPKREV
Protein: IA-2 protein tyrosine phosphatase, isoform D (Q59E11)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004212}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MARNVQQRQQHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRPPFDQQQQQEDQDPEQDPQQHPSTPQESVHHHRSPRQHELLHHQRKVPPTLPARGRHLISEGARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKDKEEKQAKDQAKVAEPRTPAKSAKQAKK
Protein: Endosomal targeting BRO1-like domain-containing protein (Q0WSL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein ELC-like
- Vacuolar protein sorting-associated protein 28 homolog 2
- Vacuolar protein sorting-associated protein 32 homolog 2
- Vacuolar protein sorting-associated protein 32 homolog 1
- Vacuolar protein-sorting-associated protein 37 homolog 1
- Vacuolar-sorting protein BRO1
- Protein ELC
- Endosomal targeting BRO1-like domain-containing protein
- Protein FREE1
- Protein SUPPRESSOR OF K
Sequence:
MGCAQSTIAVVGRKNKKRIIQESVVFVLQFRVPVQSDLQRQLKGVSPKTTINRLTCLRNQIELVAEDTGGSAISELRTALEEYLSLLSGLIKKSKDGMEGCVELKWRTLGDGRRAEICCTNLWMEMLIVIHMMAALALTEANSLMIPKDCYASGSGNGVRVVSTDCRRDAVDLLLKASGYLEFCVREILTQLPHDIKSKLPDDMQESVLQTLSIQALGQGTEIQLGLAVDSQKATLSVKRRIACEQVIYFTQAYHCLSSCEAVSHGCAKKLLRFIYWKFLEAKAAAYYYHGLVTDKGSEPACHLSAVCCFLAAAEILGESKKACLSFCLAPPVTRAPPMWGVMKHLSQKIPEVAFRKSQTYGYLLEEEEKAMQCLPELPDFQLSLRPDDFELPEIEDVSSS
Protein: Histone chaperone ASF1 (Anti-silencing function protein 1 homolog) (Q3C1E9)
Organism: Gallus gallus (Chicken)
Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. May also cooperate with HIRA to promote replication-independent chromatin assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:16537536}.
Interaction partners:
- Protein HIRA
- Chromatin assembly factor 1 subunit B
- Nuclear autoantigenic sperm protein.
- Uncharacterized protein.
- Calcineurin binding protein 1.
- Histone acetyltransferase type B catalytic subunit
- Uncharacterized protein.
- DNA helicase
- non-specific serine/threonine protein kinase
- Histone-binding protein RBBP7
Sequence:
MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM
Protein: Zinc finger protein 449 (Q8CB76)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
Interaction partners:
Sequence:
MAVALGCAIQASLNQGSVLQEYDTDCEVFRQRFRQFQYTEAAGPHEAFNKLWELCCQWLKPKMRSKEQILELLVLEQFLTILPTEIETWVREHCPDNRERVVSLIEDLQRELEIPEPQIDMDDMLLEELAPVGTVPMPPNLHLEEPSLQVMEPVQEPPVPDAWIPQAGPQDLNYSADAECQSFLDPGYQLPKLDMNFPLDHREEPWVKDLEDPKEMKQLLDSKIGFEMGIENEEDTSKEKKLETLYPFVVTLEGNALHGPILQKDYVQLENQWETSPEDLQTDLTKLVDPQNPTLGETPESPSLEEPLTPKPPKKKSPGDKPHRCPQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRSHLLGHQRTHSEEETYKCLECGKTFCHGSSLKRHLKTHTGEKPHRCPNCGKSFSRLTALTLHQRTHTEERPFKCSYCGKSFRQRPSLVIHLRIHTGEKPYKCTHCSKSFRQRAGLIMHQVTHFRGLL
Protein: Stromal interaction molecule 1 (G5EF60)
Organism: Caenorhabditis elegans
Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis.
Subcellular location: Membrane {ECO:0000269|PubMed:16966474, ECO:0000269|PubMed:17218360}; Single-pass type I membrane protein {ECO:0000269|PubMed:16966474, ECO:0000269|PubMed:17218360}. Note=Localizes to intracellular puncta in the anterior intestine and reticular structure in the posterior intestine. {ECO:0000269|PubMed:16966474, ECO:0000269|PubMed:17218360}.
Interaction partners:
- Protein orai
- Inositol 1,4,5-trisphosphate receptor itr-1
- Calmodulin
- Calmodulin-like protein
- EF-hand domain-containing protein
- Uncharacterized calcium-binding protein B0563.7
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Calmodulin-like protein
Sequence:
MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVLSSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIESLCGFPLLYLNETEHINRSIASSHFYNKSHEGSSSSGSISNAHSNPNAVNSNFVKKVSPPIPPSQQTANLRFVPTEQSDSIHSEDTSPIVEDVAISRSLTQDLAEADMQSIVSGSTNGSGSVAALKKRKGIFPKLFRRNTSKSSSLGGTSN
Protein: PRA1 family protein D (AtPRA1.D) (CAMV MOVEMENT PROTEIN-INTERACTING PROTEIN 7) (Prenylated Rab acceptor 5) (P93829)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
Interaction partners:
- Protein kinase superfamily protein
- PRA1 family protein H
- Protein At-4/1
- F19P19.6 protein
- AT4G01090 protein
- Aspartic proteinase A1
- Kinesin-like protein KIN-14Q
- Protein DA1-related 4
- Pentatricopeptide repeat-containing protein At5g66631
- Glycine-rich domain-containing protein 1
Sequence:
MANQVITGIKETAQSITGAARPWGDFLDLSAFSFPSSIADATTRVTQNLTHFRINYSIILSILLGLTLITRPIAILAFIAVGLAWFFLYFAREEPLTIFGFTIDDGIVAVLLIGLSIGSLVTTGVWLRALTTVGFGVLVLILHAALRGTDDLVSDDLESPYGPMLSTSGGGNDGARGDYSGI
Protein: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1) (Q8VCC1)
Organism: Mus musculus (Mouse)
Function: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Solute carrier organic anion transporter family member 2A1
Sequence:
MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS
Protein: Hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform X2) (A0A0R4IRW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEDKSNSFSSNKEEKADGNNVFQRQDSILKNSMGSQNMKDHGNSVGGKGDREEAMVGFDDIDAASRQYGFMQRQFGAMMQPGVNKFSLRMFGSQKAVEKEQERVQTAGYWIIHPYSDFRFYWDLIMLIMMMGNLIIIPVGITFFSEQTTTSWLVFNVASDTIFLVDLVMNFRTGIVNEESSEIILDPKVIKMNYLKSWFVVDFLSSIPVDYIFLIVEKGFDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNGMVNDSWGKQYSYALFKAMSHMLCIGYGARAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEDSILNELNDPLKEEIVNFNCRKLVATMPLFANADPNFVTGMLSKLKFEVFQPNDYIIREGTVGKKMYFIQHGVASVITKFNKELKLTDGSYFGEICLLTKGRRTASVRADTYCRLFSLSVDHFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSLLLQKFQKDLNAGVFNTQENELLKQIIRQDREMVMMVDRKQSVTGMNSTPMSGNSIINSPAQPPFATATAILGNNQLQQQAAPLSYSTSATITPSGRVPPSQGVTFSAPSVSHGNLSSSSPNPPTPLQQPAGAIMSPCSFTTSICSPPVQTPIASRTFQYGSPTASQLSLVQQALPQQSSPASLPQPPAQQQPQGASPQRSDVHKSAQALQSGSLSKDLRHLSASQPSLPHETSLAARAHPTSGESLASIQPPPMGSAAGIQAPGSVLQSGIRTNVPQRVALFRQMSSGALPPVRTAPSSAQHRDSTGSRRESAVLSSTETEQDKMRFASNL
Protein: Probable S-adenosylmethionine-dependent methyltransferase CRG1 (EC 2.1.1.-) (Cantharidin resistance protein 1) (P38892)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable S-adenosylmethionine-dependent methyltransferase which mediates cantharidin resistance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein SRL3
Sequence:
MPKTSYLNKNFESAHYNNVRPSYPLSLVNEIMKFHKGTRKSLVDIGCGTGKATFVVEPYFKEVIGIDPSSAMLSIAEKETNERRLDKKIRFINAPGEDLSSIRPESVDMVISAEAIHWCNLERLFQQVSSILRSDGTFAFWFYIQPEFVDFPEALNVYYKYGWSKDYMGKYLNDNQREILLNYGGEKLRSLLSDRFGDIEVTIYSPSDPNASTVTAENSQFLWRAAITLNQFKEFVKSWSIYTSWARDNPSKPDIADIFINELKEICHCEDLNVPLKIEWSTFYYLCRKRE
Protein: 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) (Q9ULD0)
Organism: Homo sapiens (Human)
Function: 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:23152800}.
Interaction partners:
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Isocitrate dehydrogenase subunit beta, mitochondrial
- Isocitrate dehydrogenase subunit gamma, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Succinate--CoA ligase subunit beta, mitochondrial
Sequence:
MSQLRLLPSRLGVQAARLLAAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWLENPQSVHKSWDSFFREASEEAFSGSAQPRPPSVVHESRSAVSSRTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTCPATGIPEDMLTHIGSVASSVPLEDFKIHTGLSRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTAFNLQAFEGKTF
Protein: Sirohydrochlorin cobaltochelatase CbiKC (EC 4.99.1.3) (Sirohydrochlorin ferrochelatase CbiKC) (EC 4.99.1.4) (Q72CB8)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. To a lesser extent, is also able to insert Fe(2+) into sirohydrochlorin, yielding siroheme.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18457416}.
Interaction partners:
- Precorrin-2 C20-methyltransferase
- Cobalamin biosynthesis protein CbiG
- Precorrin-4 C11-methyltransferase
- precorrin-2 dehydrogenase
- Sirohydrochlorin cobaltochelatase CbiKP
- Precorrin-3b C17-methyltransferase
- Cobalt-precorrin-5B C
- Precorrin-8X methylmutase
- Precorrin-6Y C5,15-methyltransferase
Sequence:
MVPPRWGSLDSLKPQQHLPMTKKGILLAAFGSGNRQGESTLRLFDERVRERFPGVPVRWAFTSVIMRRRLAAARKKTDSVLKALQKMWFEKYTHVAVQSLHIIPGAEYGDLVADVEAMRRDDGFTAATVGAPLLAGSGDMERSAAALLAHLPAGRKPDEAVVFMGHGTRHPAESSYEALAALVRRVDPHVHIGTMGGSRTLDHILPELQQGGVKGVWLMPLLSVVGRHATEDMAGTDPESWKSRLEASGLRCIPVLRGTAEYEGFVDIWLDHLTAAVSALDD
Protein: Isovalerate--CoA ligase CCL2 (HlCCL2) (EC 6.2.1.-) (3-methylpentanoate--CoA ligase AAE2) (EC 6.2.1.-) (4-methylpentanoate--CoA ligase AAE2) (EC 6.2.1.-) (Butanoate--CoA ligase CCL3) (EC 6.2.1.-) (Hexanoate--CoA ligase CCL3) (EC 6.2.1.-) (Pentanoate--CoA ligase CCL3) (EC 6.2.1.-) (M4IRL4)
Organism: Humulus lupulus (European hop)
Function: Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Catalyzes the ligation of CoA on isovalerate to produce 3-methylbutanoyl-CoA. Can also use butanoate, hexanoate, pentanoate, 3-methylpentanoate and 4-methylpentanoate as substrates with a lower efficiency.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23300257}.
Interaction partners:
Sequence:
MDNYRRLHTPVALCVASPPAPPTTSWKSMEGLVQCSANHVPLSPITFLERSSKAYRDNTSLVYGSVRYTWAQTHHRCLKLASALTTHLGISPGDVVATFSYNLPEIYELHFAVPMAGGILCTLNARNDSAMVSTLLAHSEAKLIFVEPQLLETARAALDLLAQKDIKPPTLVLLTDSESFTSSSYDHYNHLLANGSDDFEIRRPKNEWDPISINYTSGTTARPKAVVYSHRGAYLNSIATVLLHGMGTTSVYLWSVPMFHCNGWCFPWGAAAQGATNICIRKVSPKAIFDNIHLHKVTHFGAAPTVLNMIVNSPEGNLHTPLPHKVEVMTGGSPPPPKVIARMEEMGFQVNHIYGLTETCGPAANCVCKPEWDALQPEERYALKARQGLNHLAMEEMDVRDPVTMESVRADGATIGEVMFRGNTVMSGYFKDLKATEEAFEGGWFRSGDLGVKHEDGYIQLKDRKKDVVISGGENISTVEVETVLYSHEAVLEAAVVARPDKLWGETPCAFVTLKEGFDNDVSADQIIKFCRDRLPHYMAPKTVVFEELPKTSTGKIQKYILKEKAMAMGSLS