wanglab/gogpt-training-data huggingface dataset:
Protein: Sulfite reductase, dissimilatory-type subunit beta (EC 1.8.1.22) (Desulfoviridin subunit beta) (Dissimilatory sulfite reductase subunit beta) (dSiR beta) (Hydrogensulfite reductase subunit beta) (P45575)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria.
Interaction partners:
- Sulfite reductase, dissimilatory-type subunit alpha
- Sulfite reductase, dissimilatory-type subunit gamma
- Adenylyl-sulphate reductase, alpha subunit
- Adenylylsulphate reductase, beta subunit
- Protein DsvD
- Thiosulfate reductase, putative
- Phosphoadenosine phosphosulfate reductase, putative
- Cysteine synthase
- cytochrome-c3 hydrogenase
- Iron-sulfur protein CooF
Sequence:
MAFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF
Protein: Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) (O95573)
Organism: Homo sapiens (Human)
Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Interaction partners:
- Fatty acid synthase
- Carnitine O-palmitoyltransferase 1, liver isoform
- Lipoprotein lipase
- Beta-alanine-activating enzyme
- Diacylglycerol O-acyltransferase 1
- Monoglyceride lipase
- Long-chain-fatty-acid--CoA ligase 1
- Lysosomal thioesterase PPT2
- Palmitoyl-protein thioesterase 1
- Peroxisomal acyl-coenzyme A oxidase 1
Sequence:
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
Protein: Caldesmon 1 (E7EX44)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Protein: Inactive leucine-rich repeat receptor-like protein kinase CORYNE (Protein SUPPRESSOR OF OVEREXPRESSION OF LLP1 2) (Q9LYU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that acts as a extracellular signals regulating meristems maintenance. Modulates root, shoot and flower apical meristems maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19. In complex with CLV2, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection. CLE14 perception by CLV2/CRN complex triggers root meristem differentiation. Required for the sensing of the root CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which involves also CLV2 and leads to root growth regulation, mostly in the phloem and protophloem. Promotes the accumulation of BAM3, especially at later stages of protophloem development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754, ECO:0000269|PubMed:19843317, ECO:0000269|PubMed:19933383, ECO:0000269|PubMed:21051944, ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28607033}; Single-pass type I membrane protein {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:15308754, ECO:0000269|PubMed:19843317, ECO:0000269|PubMed:19933383, ECO:0000269|PubMed:21051944}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19933383, ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28607033}; Single-pass type I membrane protein {ECO:0000255}. Note=Requires CLV2 for export from the endoplasmic reticulum and localization to the plasma membrane. {ECO:0000269|PubMed:19933383, ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28607033}.
Interaction partners:
- Receptor-like protein CLAVATA2
- CLAVATA3/ESR
- Protein CLAVATA 3
- CLAVATA3/ESR
- AT4g01920/T7B11_18
- Cysteine/Histidine-rich C1 domain family protein
- Membrane-associated kinase regulator 5
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
Sequence:
MKQRRRRNGCSSSNTISLLLLFFLVFFSRTSTSTSCRRRTVKHLSTTSTSSTPLESRITSKVIVISIVSGILTGLVSALVLAFLVRSIVKFMKQTPILKGPVVFSPKITPKSLHAALSNGIQLLGSDLNGKYYKMVLDNGLVVAVKRLGSLEGVGSPESSSSKSVKRRLQKELELLAGLRHRNLMSLRAYVRESDEFSLVYDYMPNGSLEDVMNKVRTKEVELGWEIRLRVAVGIVKGLQYLHFSCETQILHYNLKPTNVMLDSEFEPRLADCGLAKIMPSSHTAVSCYSAPESSQSNRYTDKSDIFSFGMILGVLLTGRDPTHPFCEESASGGSLGQWLKHLQQSGEAREALDKTILGEEVEEDEMLMALRITIICLSDFPADRPSSDELVHMLTQLHSF
Protein: WASH complex subunit 3 (Coiled-coil domain-containing protein 53) (Q05B58)
Organism: Bos taurus (Bovine)
Function: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Subcellular location: Early endosome {ECO:0000305}.
Interaction partners:
- WASH complex subunit 1
- WASH complex subunit 4
- WASH complex subunit 5
- Nucleoporin Nup37
- WASH complex subunit 2A
- Heat shock factor-binding protein 1
- Heat shock factor-binding protein 1
- F-actin-capping protein subunit beta
- Protein BRICK1
- Sorting nexin-27
Sequence:
MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYHKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEKNTEESSDSESSFSD
Protein: Roundabout2 protein (Q90Z41)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGLLTPLLLFGFAFFQVYGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDREERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVDFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKAMSTDEGTYTCIAENRVGKVEASATLTVRARPVAPPQFVVRPRDQIVAQGRTV
Protein: Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) (P17712)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant. Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (By similarity). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:16542652}. Nucleus {ECO:0000269|PubMed:10456334}. Mitochondrion {ECO:0000269|PubMed:16542652}. Note=Under low glucose concentrations, associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
Interaction partners:
- Glucokinase regulatory protein
- Solute carrier family 2, facilitated glucose transporter member 2
- Glucose-6-phosphatase catalytic subunit 1
- Insulin-1
- Insulin-2
- Uncharacterized protein.
- Glucose-6-phosphatase 3
- ATP-sensitive inward rectifier potassium channel 11
- ATP-binding cassette sub-family C member 8
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
Protein: Sodium/potassium-transporting ATPase subunit alpha (Q4KMK4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGYGRSDSYRVATTQDKDEKGSPKKKKGAKDLDDLKKEVPLTEHKMSVEEVCRKFQTDIVQGLTNAKARDFLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYAIQAATEDDPAGDNLYLGIVLSAVVIITGCFSYFQEAKSSKIMESFKNMVPQQALVIREGEKMQINAEEVVAGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNIAFFSTNCVEGTARGVVVCTGDRTVMGRIATLTSGLETGKTPIAKEIEHFIHIITGVAVFLGVSFFILAVILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHKWFDNQIHEADTTEDQSGASFDKSSVTWVALARVAALCNRAVFKAGQDSLPILKRDVAGDASESALLKCIELSSGSVKAMREKNKKVAEIPFNSTNKYQLSIHETEDNNDNRYLLVMKGAPERILDRCSTIMLQGKEQPMDEEMKEAFQNAYLELGGLGERVLGFCHVLMPEDQYPKGFAFDTDDVNFQTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDYSQEQIDEVLRNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADTILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIVNIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPMRDKLVNERLISIAYGQIGMIQALGGFFAYFVILAENGFLPSLLVGIRLNWDDRAMNDLEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADVIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEVRKLLLRRNPGGWVEKETYY
Protein: ADP-ribosylation factor, putative (Q57UH8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 26S proteasome regulatory subunit 4 homolog
- Coatomer subunit gamma
Sequence:
MGQSKTKLQVVMCGLDNSGKTTIINQVKPAQSSSKHITATVGYNVETFEKGRVAFTVFDMGGAKKFRGLWETYYDNIDAVIFVVDSSDHLRLCVVKSEIQAMLKHEDIRRELPGGGRVPFLFFANKMDAAGAKTAAELVEILDLTTLMGDHPFVIFASNALKGTGVHEGFSWLQETASRQSGKAGTKRG
Protein: alpha-1,2-Mannosidase (EC 3.2.1.-) (Q9VAP8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
- alpha-1,2-Mannosidase
- Glucosidase II subunit alpha
- Mannosyl-oligosaccharide glucosidase
- Endoplasmic reticulum lectin 1
- Alpha-mannosidase
Sequence:
MKDGGHITLTLPPGSAATTDERGRKSLRRAWNQLPRCQRNLIILGITGFCVTVLLCLSGDQLLAASLKDVDTKAEVAAYQMPLPNPHHHPGVDKDVPKDTAAVPVPADKRAPRVEAVSDKFNELVAYGEANSAENVARLPETVAAEGLPQASAMAVALPPPDSNKEQDIGGIDILNNVEEPVAQDPAEPLSEGEQLEQAIKNPLTLGGVSFKEHLKKIKPILAKGQHFHGATNERQSAVVAAFKHSWAGYKKYAWGHDNLKPISQYSHEWFGLGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLSGDTMFLAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPKWSPDSSTSEVTTIQLEFRDLSRSTNISIYEQVAHKVNEKVHDLEKNHGLVPIFINANTGTFRNYATISLGARGDSYYEYLLKQWIQTGRKDNDNLILDYMQAVDGVLTQLMRRTPREHWVYIGELINGKDFKPKMDHLTCYLPGTLILGHQNGMPDSHLILARDLLDTCYQTYMMNPTHLAAEISYFALTEKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGNRTYQDMGWKIFQAFETHAKVNAGYTSMGNVKNTQSTRLRDLMESFWMSETLKYFYLLFSDDRKEIDLEQWVFNSEGHPLPVYPLKT
Protein: Interleukin-1 (Q8UUQ3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
Sequence:
MDFESNYSLIKNTSESAAWSSKLPQGLDLEVSHHPITMRHIANLIIAMERLKGGEGVTMGTEFKDKDLLNFLLESAVEEHIVLELESAPPASRRAAGFSSTSQYECSVTDSENKCWVLMNEAMELHAMMLQGGSSYHKVHLNLSSYVTPVPIETEARPVALGIKGSNLYLSCSKSGGRPTLHLEEVADKDQLKSISQQSDMVRFLFYRRNTGVDISTLESASFGNWFISTDMQQDYTKPVDMCQKAAPNRLTTFTIQRHN
Protein: Probable anion transporter 6, chloroplastic (Phosphate transporter PHT4;5) (Q3E9A0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inorganic phosphate and probable anion transporter.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:18086223}; Multi-pass membrane protein {ECO:0000269|PubMed:18086223}.
Interaction partners:
- Inorganic phosphate transporter 2-1, chloroplastic
- Alpha/beta-Hydrolases superfamily protein
- Defensin-like protein 268
- F-box/FBD/LRR-repeat protein At1g13570
- Putative defensin-like protein 288
- ATG8-interacting protein 2
- Inorganic phosphate transporter 1-4
- Defensin-like protein 286
- Ceramide synthase 1 LOH3
- Probable transcription factor At4g00390
Sequence:
MARLTLRPHNHFFSSPIYAHKQPFLSVYTIFPHHHQNPLIKSRVKCSASGTERVRESKKLPPKDPIEDPKPQLPIPEVLSTETGFEQNWPPWKNIPQRYKLIGATSLAFVICNMDKVNLSIAIIPMSHQFGWSSSVAGLVQSSFFWGYALSQLPGGWLSKIFGGRKVLEIGVFTWSFATALVPLLAGFMPGLIFSRILVGIGEGVSPSAATDLIARTIPVKERSRAVGFVFGGLSLGSVMGLLLAPPIIETFNWESVFYLFGLLGVGWFVGFQFLNEEEVSYKGNEISTSHKSENATKEELGSSLKEIPWKSFFQSPAVWAMIYTHFCGSWGHYTCLSWLPTYFSEALSLNLTEAAWVSILPPLASIVVTSLASQFADYLITNGVDTTTVRKICQTIAFVAPAICMTLSSVDIGLPPWEIVGILTAGLALSSFALSGLYCTHQDISPEYASILLGITNTVGAVPGIVGVALTGFLLDSTHSWTMSLFVPSIFFYLTGTVVWLAFASSEPQTFRKEDS
Protein: snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit) (O75971)
Organism: Homo sapiens (Human)
Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular location: Nucleus.
Interaction partners:
- snRNA-activating protein complex subunit 1
- snRNA-activating protein complex subunit 4
- snRNA-activating protein complex subunit 3
- snRNA-activating protein complex subunit 2
- Transcription initiation factor IIB
- TATA-box-binding protein
- Transcription initiation factor IIA subunit 2
- Transcription initiation factor IIA subunit 1
- Transcription factor IIIB 50 kDa subunit
- DNA-directed RNA polymerase III subunit RPC4
Sequence:
MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHDMLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS
Protein: Sister chromatid cohesion protein PDS5 (Precocious dissociation of sisters protein 5) (Q04264)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11062262, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Sister chromatid cohesion protein 1
- Protein RAD61
- Cohesin subunit SCC3
- Structural maintenance of chromosomes protein 1
- Structural maintenance of chromosomes protein 3
- N-acetyltransferase ECO1
- Meiotic recombination protein REC8
- Separin
- Structural maintenance of chromosomes protein 5
- DNA topoisomerase 2
Sequence:
MAKGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEVISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPGLFKKYNISTGASIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTLFKDQIRTLKTIIKDLDDPDAEKNDNLSLEEALKTLYKASKTLKDQVDFDDTFFFTKLYDFAVESKPEITKYATKLIALSPKAEETLKKIKIRILPLDLQKDKYFTSHIIVLMEIFKKFPHVLNDDSTDIISYLIKEVLLSNQVVGDSKKEIDWVEDSLLSDTKYSAIGNKVFTLKLFTNKLRSIAPDVPRDELAESFTEKTMKLFFYLIASGGELISEFNKEFYPTPSNYQTKLRCVAGIQVLKLARISNLNNFIKPSDIIKLINLVEDESLPVRKTFLEQLKDYVANELISIKFLPLVFFTAYEPDVELKTTTKIWINFTFGLKSFKKGTIFERALPRLIHAIAHHPDIVGGLDSEGDAYLNALTTAIDYLLFYFDSIAAQENFSLLYYLSERVKNYQDKLVEDEIDEEEGPQKEEAPKKHRPYGQKMYIIGELSQMILLNLKEKKNWQHSAYPGKLNLPSDLFKPFATVQEAQLSFKTYIPESLTEKIQNNIKAKIGRILHTSQTQRQRLQKRLLAHENNESQKKKKKVHHARSQADDEEGDGDRESDSDDDSYSPSNKNETKKGHENIVMKKLRVRKEVDYKDDEDDDIEMT
Protein: Maternal effect protein oskar (P25158)
Organism: Drosophila melanogaster (Fruit fly)
Function: Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.
Subcellular location: Endosome {ECO:0000269|PubMed:33891588}. Note=Colocalizes with endocytosed yl/yolkless on endosomes. {ECO:0000269|PubMed:33891588}.
Interaction partners:
- Maternal effect protein staufen
- Chorion peroxidase
- ATP-dependent RNA helicase vasa
- Thioredoxin-1
- Bruno 1, isoform B
- Deubiquitinase otu
- Protein matrimony
- Homeotic protein bicoid
- FI20148p1
- CG5272 protein
Sequence:
MAAVTSEFPSKPISYTSTNTSAKTYYLKSVKKRVTTCFQQLRDKLQSSGSFRKSSSSCLNQIFVRSDFSACGERFRKIFKSARKTELPELWKVPLVAHELTSRQSSQQLQVVARLFSSTQISTKEITYNSNSNTSENNMTIIESNYISVREEYPDIDSEVRAILLSHAQNGITISSIKSEYRKLTGNPFPLHDNVTDFLLTIPNVTAECSESGKRIFNLKASLKNGHLLDMVLNQKERTSDYSSGAPSLENIPRAPPRYWKNPFKRRALSQLNTSPRTVPKITDEKTKDIATRPVSLHQMANEAAESNWCYQDNWKHLNNFYQQASVNAPKMPVPINIYSPDAPEEPINLAPPGHQPSCRTQSQKTEPTENRHLGIFVHPFNGMNIMKRRHEMTPTPTILTSGTYNDSLLTINSDYDAYLLDFPLMGDDFMLYLARMELKCRFRRHERVLQSGLCVSGLTINGARNRLKRVQLPEGTQIIVNIGSVDIMRGKPLVQIEHDFRLLIKEMHNMRLVPILTNLAPLGNYCHDKVLCDKIYRFNKFIRSECCHLKVIDIHSCLINERGVVRFDCFQASPRQVTGSKEPYLFWNKIGRQRVLQVIETSLEY
Protein: ENTH domain-containing protein 1 (Epsin-2B) (Q8IYW4)
Organism: Homo sapiens (Human)
Interaction partners:
- Epidermal growth factor receptor substrate 15-like 1
- Clathrin heavy chain 1
- Clathrin heavy chain 2
- AP-2 complex subunit alpha-1
- Epidermal growth factor receptor substrate 15
- Clathrin light chain B
- Clathrin light chain A
Sequence:
MAFRRQVKNFVKNYSDAEIKVREATSNDPWGPSSSLMLDISDLTFNTISLSEIMNMLWHRLNDHGKNWRHVYKSLTLMDYLIKNGSKKVIQHCREGFCNLQTLKDFQHIDEAGKDQGYYIREKSKQVITLLMDEPLLCKEREVACRTRQRTSHSILFSKRQLGSSNSLTACTSAPTPDISASEKKYKLPKFGRLHNKRNVCKAGLKQEHCQDVHLPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVSPITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVSKSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPILAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCSGFQSTKDFPQEPEAKNSISVLLREVKRAIARLHEDLSTVIQELNVINNILMSMSLNSSQISQSSQVPQSSEGSSDQI
Protein: F-box protein At3g59000 (Q2V3N5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Alpha/beta hydrolase family protein
- AT5g16210/T21H19_130
- At3g15420
- Expressed protein
- Nucleic acid-binding, OB-fold-like protein
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- BZIP transcription factor-like protein
- Transcription initiation factor TFIID subunit 12
- Protein prenylyltransferase superfamily protein
- Probable galacturonosyltransferase 14
Sequence:
MDRVGSLPDELLSHILSFLTTKEAALTSLLSKRWRYLIAFVPNLAFDDIVFLHPEEGKPERDEIRQSFMDFVDRVLALQAESPIKKFSLKCRIGVDSDRVDGWISNVLNRGVSELDLLIILGMTMEDSYRLSPKGFASKTLVKLEIGCGIDISWVAGSIFLPMLKTLVLDSVWFYVDKFETLLLALPALEELVLVDVNWLDSDVTISNASLKTLTIDSDGHLGTFSFDTPSLVYFCYSDYAAEDYPVVKMENLREARIFLLVTDNEIERVRLPINDGLEDAMDNVVLRFGHVGKLMNGIRNVEYLELSADTLEVLSLCCESMPVFKNLKSLAIKSTEGRGWQAMPVLLRNCPHLEFLLIEGLLHHVTDKCGDACDCVPREDKGRSLTSCPVNMLEIHGFRGTKKEMQMIKHFLDYFPSLKEMDIYADEDGPTNLEAPGMFEQITQLFTLYDEFYTCDVQFMVRGSLYKKLTAQCCVFKEENLPHRLVRTLG
Protein: DNA topoisomerase 2 (EC 5.6.2.2) (Q14TE9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MAKSSLAGVDGALTWVNNAAKKEELETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLAKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNAREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWEKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDAQNPHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMSGKAVKGKVGKAKVKKLQLEETMPSPYGRRIVPEITAMKADASRKLLKKKKGDPDTTVVKVEFDEEFSGTPAEGTGEETLTPSAPVNKGPKPKREKKEPGTRVRKTPASTGKPNTKKVKKRNPWSDDESKSESDLEEAEPVVIPRDSLLRRAAAERPKYTFDFSEEEEDDADDDDDNNDLEELKVKASPITNDGEDEFVPSDGIDKDEYAFSPGKSKATPEKSSHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDTTSVFAPSFGLKQTDKVPSQTVAAKKGKAPSDAAAPKAKRAPRQRKVVEPANSDSDSELGNIPKKTAAPKGKGRGAKKRKASGSENEGDYNPGRKPSKTASKKPKKTSFDQDSDVDIFPSDFTSEPPALPRTGRARKEVKYFAESDEEEDVDFAMFN