Protein: [F-actin]-monooxygenase Mical (EC 1.14.13.225) (Molecule interacting with CasL protein homolog) (Q86BA1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Plexin A, isoform A
- Semaphorin-1A
- Methionine-R-sulfoxide reductase B1
- LD44762p
- Uncharacterized protein, isoform A
Sequence:
MSRQHQRHHQQHHHLPPHQQPQQQMPQQQQQLTAQQQQQQQLLMAEHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGGGWRAAVTPADHPVSHYEFDVLIGADGKRNMLDFRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPGRRKRRSGDLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDLRQKYRINHTHAQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGGAAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANIEERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLLFPDRERGDIPSALPRTADEQFSDRIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKIELSKKTEIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSREAEKFKDIDQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSSSKVALAFKKQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKPLPQRTNKARKSAAAQPASPAVPPTAGSVPTAAATSEHMDTTPPRDQVDLLETSRANASADAMSDDEANVIDEHEWSGRNFLPESNNDSQSELSSSDESDTESDSEMFEEADDSPFGAQTLQLASDWIGKQYCEDSDDSDDFYDSSEGIADDGKDDTEGEEFKKARELRRQEVRLQPLPANLPTDTETEKLKLNVDNKENMADRSSLKSGNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHMNNMVKMNKDLEVLAKENLVKSDILRKLTLKEKWLAENAAIAAGQKVTPTPSATAPGLQPKSKFDEKFEKVVSPPQPVVEPKPKPVIDFNLDELKPRKPNFEERPKEQLPRPESLKKPPQQKPKGSSTNVSRSNSLKSNASNGSPKVKKAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKPNKELNSKLKEIQASSFAGTMDHIKSQLTMPTVSAQAPPSMDLSKYFPNQKQEKSSTSSTNKNQVTLKDVNLAKYFPSSPAPQRRTVETVADRLKKSQTEAALAKTKLLEDQANNQAEKTKKEVEKEGESKKITKKVADSKAVPPKRQASLDTFSLREHQMDGALDLTKKKGPTKASAGVKKPAKSGSTTSVTKATATSKGKTIKIVKKIVPKGTKAKKAAEAAQESAVVEAPPEKKPPKDEAERILDEILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVELGLPKRSSKKLVKTKSLGEGDFDMKPSKERLTGVQNILKRFESMSSVTSQNSDEQAAFKLRRMESTTSNLSSLTRSRESLVSVSDSMSDLEKTMDYLRNEWRNEATNFLQKKRDKFYAKKEEQEKESKILAKPDPLDNLPVQYRDSKLAKFFGLAASKSPENRKSPIKKKKSPSKTPKVTKANNSLEELAKISNVRQTKKAQPKTLKPVEVKPLKPASPVPDDFEILDLLEKATEAKELERSKTKSPAVESISQTPKEAIVEISLPVEDIKNLPKTGCDKSSNSSRRGSQSSLIMSRRHSEISLNEKLNQDALAALNQIEKEREAEQVDELFQSMVEEMEQEPQPTAIVEPPEEDIDADSLCTTISKSPSAQPVTVVKRGSSEDQSIEKLFSHFSDEMLVNVEFDSNDELVGITPRATLVSRNTEDRDYLDKLESLERDEETFQPVVGEKFIQENVQDEVDGLHFPSRPQRRPKSSSSSSEPSLPVAPQRLKKKLSKLDPEDMPPSVQDLLQQVYQKNIQPELVEVIPVEGKQTLRFPSMLAEEDVDEVDHSKEGIKKIETAPEEVRKVTEPEDVARVIPSPIKPSISQSNSLKSENSSGSSLVEIPKIITPPKSSSKENSSDWDMEKLPASPMPRRRLLPNQTPYKAPSVASKESSLEWDMEKLPNSPMLPRRNKMRAISPSTNPVQLLNNLPSDVDDEAAQRRLIEDFEQERRQALIKRDENFEAIAAEQRRRDSLQSSSNSSSKRSLPPPTPPMMASRRGTTQDTNRTQDTASRHEGTPPMFKKLDVDGSGTSMDSTSCSTRRSSFAFIELQDNKPVIVPMPKKLKLPKPEPPRFVPEPVATDEPVPEVFQGRAWPKTQLEGEVDLGDSDNEDETEKLKKQLPEYARSDSPPSAAFKNRKWPDGKTVFDKRAESLEEEDIFEGLLSPRKRGSQRFMDKPRSQSPQPFKPLANSSRKSSKSFSDLKKGPSLQSLSAQSSQDTDTLSTTTTVATARPASYANYEDPMDASTQALLDRSKRLHNRKRDFVNERVVERNPYMRDVLRSTDRRDYDDVDEDLTSYRPRHYASSTLNRFPNTTIRKSNNYDYLSPSSDYLSRRSYIPSASATSSYYPSTTRSSHLSDLFRRRSPASGTVSALSGYGNKESCIGLALDRVGHLIESKCTWVRSTKVQTESESTSPDEVELNSATEISTDSEFDNDEIIRQAPKIFIDDTHLRKPTKVQIKSTMIGPNAASAGLHQKQLAAREKGGSYLQKYQPQPPLPQFKPLVQVDPTLLIGSQRAPLQNPRPGDYLLNKTASTEGIASKKSLELKKRYLLGEPANGNKIQKSGSTSVLDSRIRSFQSNISECQKLLNPSSDISAGMRTFLDRTKLGEGSQTTPGQTNELIRSATSNVINDLRVELRIQKTGSSHSTDNEKENVFVNCKNELNKGMEYTDAVNATLLDQLARKSSPTTPTNKTVVEVIDLVTPEKPIDIIDLTALETPKKQLVDGSAMDVDERLTPDSNKISELQQEVKEEPKPDVSRDVKECIPDILGHIKEGTGSKEPGGEDQQSLLEQSDEEKRDSPEKDVAEHELYEPDSVQIQVPNIPWEKSKPEVMSTTGSSGSICSSSDSSSIEDIQHYILESTTSPDTQTVGGKHNVPRLEVHDTSGALMQVDSLMIVNGKYIGDPEDVKFLDMPANVIVPPAPALKTNELDMEDDQEAEAEPVTATPEPVECTVIEAERRVTAPPPLPEMGPPKLKFDSKNENKIESLKNLPLIVESNVEHSQAVKPITLNLSNLARTPDTPTTPTAHDSDKTPTGEILSRGSDSETEHTGTGQVLTETELSDWTADDCISENFVDLEFALNSNKGTIKRRKDRRRSGASKLPSGNEVIHELARQAPVVQMDGILSAIDIDDIEFMDTGSEGSCAEAYSATNTALIQNRGYMEYIEAEPKKTTRKAAPPSSYPGNLPPLMTKRDEKLGVDYIEQGAYIMHDDAKTPVNEVAPAMTQSLTDSITLNELDDDSMIISQTQPTTTEESEALTVVTSPLDTSSPRVLDQFASMLAAGKGDSTPSSSEQQPKTSTVTSSSTGPNSSTTGNVSKEPQEEDLQIQFEYVRALQQRISQISTQRRKSSKGEAPNLQLNSSAPVIESAEDPAKPAEEPLVSMRPRTTSISGKVPEIPTLSSKLEEITKERTKQKDLIHDLVMDKLQSKKQLNAEKRLHRSRQRSLLTSGYASGSSLSPTPKLAAACSPQDSNCSSQAHYHASTAEEAPKPPAERPLQKSATSTYVSPYRTVQAPTRSADLYKPRPFSEHIDSNALAGYKLGKTASFNGGKLGDFAKPIAPARVNRGGGVATADIANISASTENLRSEARARARLKSNTELGLSPEEKMQLIRSRLHYDQNRSLKPKQLEEMPSGDLAARARKMSASKSVNDLAYMVGQQQQQQVEKDAVLQAKAADFTSDPNLASGGQEKAGKTKSGRRPKDPERRKSLIQSLSSFFQKGSGSAASSSKEQGGAVAAVHSEQSERPGTSSSGTPTISDAAGGGGGGGGVFSRFRISPKSKEKSKSCFDLRNFGFGDKDMLVCNAASPAGATSASQKNHSQEYLNTTNNSRYRKQTNTAKPKPESFSSSSPQLYIHKPHHLAAAHPSALDDQTPPPIPPLPLNYQRSDDESYANETREHKKQRAISKASRQAELKRLRIAQEIQREQEEIEVQLKDLEARGVLIEKALRGEAQNIENLDATKDNDEKLLKELLEIWRNITALKKRDEELTIRQQELQLEYRHAQLKEELNLRLSCNKLDKSSADVAAEGAILNEMLEIVAKRAALRPTASQLDLTAAGSASTSAEATGIKLTGQPHDHEESII