Protein: Bromodomain adjacent to zinc finger domain protein 1A (Cbp146) (O88379)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (By similarity). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (By similarity). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (By similarity). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (By similarity). May have a role in nuclear receptor-mediated transcription repression (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12434153}. Note=Localizes to pericentric heterochromatin (PubMed:12434153). May target the CHRAC complex to heterochromatin (By similarity). Localizes to sites of DNA damage (By similarity). {ECO:0000250|UniProtKB:Q9NRL2, ECO:0000269|PubMed:12434153}.
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- DNA polymerase epsilon subunit 3
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
- Chromatin accessibility complex protein 1
- Tyrosine-protein kinase BAZ1B
- Remodeling and spacing factor 1
- Chromatin remodeling regulator CECR2
- Histone-binding protein RBBP7
- Bromodomain PHD finger transcription factor
- Histone-binding protein RBBP4
Sequence:
MPLLHRKPFVRQKPPGDLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQEALESERKARQNLQSFPEPLIIPVLYLTNLTRRSRLHEICDDIFAYVKDRYFVEETVEVIRNNGTRLQCRILEVLPPLHQNGFANGHLSSADGETIVISDSDDSETQSSSFHHGKKKDAIDPLLFRYRVQPTKKEMYESAVVKATQISRRKHLFSRDKLKLFLKQHCEAQDGVIKIKASSFSAYNIAEQDFSYFFPDDPPTFIFSPANRRRGRPPKRISFGQEDSIASKQTAARYRNKAIKERDKLLKQEEMRALAFEKAKLKRERADALEARKREKEDKEKKREELKKMVEEERLKKKEEKERLKIEREKEREKLREEKRKYMEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEVFGDALMVLEFLNAFGELFDLQDEFPEGVTLAEVLEEALVGNDSEGPLCELLFFFLTAIFQAMAEEEEEVAKEQITDADTKDLTEALDEDADPTKSALSAVAALAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDVLRQAKQEFRELKAEQHRKEREATAARIRRRKEEKLKEQEQKMKEKQEKLKEDEQRNSAAVPGYGEEEREDFDTSTENKNIEQKDLDPDVVTEDEDDPGSHKRSRRGKVGQTAVKQCIKQEEMNYCIKQEPLSADAEEALRQEQQQKEKELLDKIQSAIACTNIFPLGRDRLYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSFHNNAQPRDPQVSIKTEESFLSESTSSLDQGPFDDSVLLPKPVHKPNRWCFYSSCAQLDQLIDALNSRGHRESALKETLLQEKSRICAQLAHFSEEKFHFSDKPQADSKPVSSRGRSSGACDISQMSAERQLELRLRDFLLDIEDRIYQGTLGAIKVTDRQVWRSALENGRYELLSEESKENGVIKTVNEDVEEMEMEQARVIVRDRLLGIKTETPSTISTSASTPQSVSNVVHYLALALFQIEQGIERRFLKAPLDGNDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVMWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKAVPDGDWFCPECRPKQRSRRLSSRQRPSLESDEEMEEGMEDDDDEVDDDDEEGQSEEEEYEVEQDEEDSDDDEALSPPKRGRPQVRLPIKTKGRFGPSFPSRSQRQDPGRYPSRSQQSTPKNTAKSASKNLRKTRSAPPTETRSLRVGSRSTRHSPSALQDVFVELLSPHSKRRGRKGADHTPEHSPSFTNFRVSTSRSSRQLIPLNTAESLSLQHSESKRRGRKRQSTESSPVPLNRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVSPSTVDQVSTPLAAKKSRI