wanglab/gogpt-training-data huggingface dataset:
Protein: P-glycoprotein 14 (EC 7.6.-.-) (G5EG61)
Organism: Caenorhabditis elegans
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:37930961}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Putative sphingolipid delta
Sequence:
MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFEEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEAAIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGTSLILLLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV
Protein: Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) (Q9WV32)
Organism: Mus musculus (Mouse)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15143}. Nucleus {ECO:0000250|UniProtKB:O15143}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 3
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
- Actin-related protein 2/3 complex subunit 1A
Sequence:
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWNKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLVDADKKMAVATLASETLPLLAVTFITENSLVAAGHDCFPVLFTYDNAAVTLSFGGRLDVPKQSSQRGMTARERFQNLDKKASSEGGAATGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
Protein: Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) (Q9UK32)
Organism: Homo sapiens (Human)
Function: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:15632195}. Nucleus {ECO:0000269|PubMed:15632195}. Note=Predominantly cytosolic.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- GTPase KRas
- Tuberin
- Mitogen-activated protein kinase 7
- Hamartin
- GTPase HRas
- GTPase NRas
- TBC1 domain family member 7
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Sequence:
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL
Protein: Chromodomain helicase hrp1 (EC 3.6.4.-) (ATP-dependent helicase hrp1) (Q9US25)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Seems to play a role in mitotic chromosome segregation and maintenance of chromatin structure. Has ATPase activity.
Subcellular location: Nucleus.
Interaction partners:
- FACT complex subunit spt16
- FACT complex subunit pob3
- Histone H4
- Putative ATP-dependent RNA helicase ste13
- Mediator of RNA polymerase II transcription subunit 15
- Uncharacterized RNA-binding protein C660.15
- Protein sum2
- ARS-binding protein 2
- Chromodomain helicase hrp3
- Transcription elongation factor spt5
Sequence:
MEPEHSNYDLKNHPTSVQESTLNGSAVTDPQFGNTTNSLPSMNGLLNHENSFASQQSLSSSAFDDSEIVTSTANSTVVSSALSTPKIDDAQNSDDVRVDGTRRSSRAKRPVYRDFSYTEIDEHEIPIPKKRKSKPAPKQKKSVASDDEDAYDKRHRFSINSASGTEIRTSLRSSKGKSVNYNEQEFYDDFEDEEEEVEEQVEEEYEPIIDFVLNHRKRADAQDDDPKSSYQYLIKWQEVSHLHNTWEDYSTLSSVRGYKKVDNYIKQNIIYDREIREDPTTTFEDIEALDIERERKNMLFEEYKIVERIVASETNEEGKTEYFVKWRQLPYDNCTWEDADVIYSMAPNEVYQFLQRENSPYLPYKGVFYNTRPPYRKLEKQPSYIKGGEIRDFQLTGINWMAYLWHRNENGILADEMGLGKTVQTVCFLSYLVHSLKQHGPFLIVVPLSTVPAWQETLANWTPDLNSICYTGNTESRANIREYEFYLSTNSRKLKFNILLTTYEYILKDKQELNNIRWQYLAIDEAHRLKNSESSLYETLSQFRTANRLLITGTPLQNNLKELASLVNFLMPGKFYIRDELNFDQPNAEQERDIRDLQERLQPFILRRLKKDVEKSLPSKSERILRVELSDMQTEWYKNILTKNYRALTGHTDGRGQLSLLNIVVELKKVSNHPYLFPGAAEKWMMGRKMTREDTLRGIIMNSGKMVLLDKLLQRLKHDGHRVLIFSQMVRMLNILGEYMSLRGYNYQRLDGTIPASVRRVSIDHFNAPDSPDFVFLLSTRAGGLGINLNTADTVIIFDSDWNPQADLQAMARAHRIGQKNHVNVYRFLSKDTVEEDILERARRKMILEYAIISLGVTEKSKNSKNDKYDAQELSAILKFGASNMFKATENQKKLENMNLDDILSHAEDRDSSNDVGGASMGGEEFLKQFEVTDYKAEDLNWDDIIPEEEMERIEEEERMLAAQRAKEEERERREEEERENDEDHPSRTYKRTTKSITKRQQRREEMVREKEIRLLYRAMIKFGLVDERFDTIVKEAELQATDPKRIYSLSADMVKACDEAVERLGADDTKNKQPRKAILIEFKGVKNINAETVTLRVKDLTHLHRAYKGLDPLKQIIGYPIRSVHSWNCSWGIKEDSMLLAGINKHGFGCWQAIKNDPDLGLHDKIFLDEAKNDKESRYVPSAVHLVRRGEYLLSVVREHPDLFVVKTDQPTKRKYNRKAPTKSSTRQTTLDGSISNTKKSSRTKKKKEEETNRGDETSPEGTVGEDEVEEEPRQAEPPKRALRSNSGKAASNKRTTRNSMKTHSAMDTLTAVAALDAELDNMSNEKAKEEVDHVKSENGESVNEPNTEDLSLETEENTTVSDISPLVKNEA
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q7KTC4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
Sequence:
MADDTSSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV
Protein: Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5) (Q8BGY6)
Organism: Mus musculus (Mouse)
Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Beta-1,4-galactosyltransferase 4
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- Beta-1,3-galactosyltransferase 5
- Beta-1,3-galactosyltransferase 1
- Beta-1,3-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 6
- Hexosyltransferase
- Beta-galactosidase
Sequence:
MRLFVSRRVKRWKIFHFFVTCFILSFMVFWSPINNYIMSHMKSYSYRYLVNSYGFVNNSLSLKHSSVQPHYPYLINHREKCQAQDVLLLLFIKTAPENYGRRSAIRKTWGNENYVQSQLNANIKILFALGTPGPLKGKELQKRLIGEDQVYKDIIQQDFIDSFHNLTSKFLLQFSWANTFCPHAKFLMTADDDIFIHMPNLIEYLQGLEQIGVRDFWIGHVHRGGPPVRDKSSKYYVPYEMYKWPAYPDYTAGAAYVVSRDVAAKIYEASQTLNSSMYIDDVFMGLCANKVGILPQDHVFFSGEGKIPYHPCIYEKMMTSHGHLQDLQDLWIEATHPKVKNISKGFFGQIYCRLIKIVLLCRLTYRNSYPCWAAFA
Protein: Formin-like protein 2 (AtFH2) (AtFORMIN-2) (O22824)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might be involved in the organization and polarity of the actin cytoskeleton.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Profilin-5
- Profilin-1
- Profilin-4
- Profilin-2
- Profilin-3
- DUF1005 family protein
- Formin-like protein 12
- FH protein interacting protein FIP2
- Exocyst complex component SEC10a
- Actin-depolymerizing factor 5
Sequence:
MTTIPFCFLFVAFFFSSSTADQRHHSRHLLHQPFFPVVTAAPPPYQPPVSSQPPSPSPHTHHHHKKHLTTTTPPPHEKHLFSSVANPPPPPPSPPHPNPFFPSSDPTSTASHPPPAPPPPASLPTFPANISSLLFPTHNKQSKPPSNGHIARLVTITASVISAAALLSLFAVFIIFIRRTRHRRRSSPADDTKSTRSDALQLFNASPSDGSKKQKQHQQPPKYTSSHTSSEFLYLGTLVNSRSNGLEQQKSPISLSGGITGVLELPPPASSSSSSSYSQYHKLGSPELRPLPPLPKLQSFTPVYKSTEQLNPKRQDFDGDDNENDEFFSPRGSSGRKQSPTRVSDVDQIDNRSINGSGSNSCSPTNFAPSLNASPGTSLKPKSISPPVSLHSQISSNNGIPKRLCPARPPPPPPPPPQVSEVPATMSHSLPGDDSDPEKKVETMKPKLKTLHWDKVRASSSRVMVWDQIKSNSFQVNEEMIETLFKVNDPTSRTRDGVVQSVSQENRFLDPRKSHNIAILLRALNVTADEVCEALIEGNSDTLGPELLECLLKMAPTKEEEDKLKELKDDDDGSPSKIGPAEKFLKALLNIPFAFKRIDAMLYIVKFESEIEYLNRSFDTLEAATGELKNTRMFLKLLEAVLKTGNRMNIGTNRGDAHAFKLDTLLKLVDIKGADGKTTLLHFVVQEIIKFEGARVPFTPSQSHIGDNMAEQSAFQDDLELKKLGLQVVSGLSSQLINVKKAAAMDSNSLINETAEIARGIAKVKEVITELKQETGVERFLESMNSFLNKGEKEITELQSHGDNVMKMVKEVTEYFHGNSETHPFRIFAVVRDFLTILDQVCKEVGRVNERTVYGSMPLHSPSNQTATPLFPVVINNNSRLSPSGSLDDDDGSF
Protein: Heptose kinase (Lipopolysaccharide core heptose(I) kinase RfaP (EC 2.7.1.-)) (Lipopolysaccharide kinase InaA family protein) (Q9S661)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MAGWTLEPDYRHLAADFGSLDSVFALEGERLTRDPLSEVIRIERDGVRYYVKRYRSAGKGLRRYLARPRIKAEWQNLKRFEKWGIPTAEVVAWGLERKAGAFQRGAMITRELPGTEDLSVLACNRDPRLKDPRWVDGVSRQIAKATRLMHDQHFTHNDLKWRNLLVDDQPLVYFIDCPNGAFWWSFMLRYRITKDLACLDKVAKYHLSRTQRLRFYLQYRRRRHLNESDKKRIRQVVAFFEGRE
Protein: Enhancer of polycomb-like protein (A0A0B4KFP2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361124}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- Transcription-associated protein 1
- Chromatin modification-related protein MEAF6
- Brahma associated protein 55kD
- MRG/MORF4L binding protein
- Inhibitor of growth protein
- NuA4 complex subunit EAF3 homolog
- YEATS domain-containing protein 4
- Histone acetyltransferase Tip60
- RuvB-like helicase 1
Sequence:
MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICTGLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQQQRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHPLILTVKTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKRDHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPTGLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADSEEEDYFGAGAQNGNKLGSESEEETPFAFRRRSSCVYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTLTSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKQRDPDQLCKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKFENDVDDEFVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLKRSSEAVATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVSENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQEAEELVGGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGPSLEEVAKTIKREMIDADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSIIRHTAVKKELEAQQHQQQVQHEQMQAARKMEEDEAAPCLNQLPDVIRLRNIRNSQVHARPKDLFVQAPVDEEFNADYMGGLSPTSSQRLDICNELLSEIRRDWLHFRPKTPTDELSDSQDCEVGKTCDSHAVDWTQDTPISVELNRLGKREAEESDSSSYFLSSGFKYRDLESDAQLLQTVQAQDYARGSSKSPNCSGSGSGSALEFNLSGGDSLNDINNLLGCDDEDDNHEHMLDNILQECAMDDPKALNQATNFWNGILDGEAAVDEVEMADQLLDCIDEKKSKVGAADTSKRAGRNRKARLIQAPVGSSAFTVCPTAETLKERELFFSQAPPVEVPPKEKTPAEVELPEVVVKETANLPVKVEAVEKPQSEVLPVAPQPQQLQPQAITLPTTQLINIPAQISTQKQHQQPQVTQLLNQFANAGPQIIARTEYGGGAAVGDIVTITPHTGSSPLPTLTAQQQLQHQLAQAQLRNVTVQQRQATPQNPNQNQNPQQQLLFQMQRDPSRSLTPLQAAGAGATGNHLIYTTSCGEIVTAGAAASASQKVTYAIQKAGVSSGGATTASIGPNTVITLSNVKVQNDDISSGGSGNSGSSVNIINTASGQQLAVHSIAGMQQQGQQQVQQVTTSTPLLVATPTRNNVQQQQQQLVQQQPIVWRQVSGTNTAVATTAVLSTTVDSSPKAVTNQILWTSRATQKRQLNGPENTDINKLLLNRKLPRKQQIQQQHQQIQLTKQQLQQLVQHEELDDLVATSTGNSGDQMETGDGLQQQQQQQQQQQQLQKLSKVIKMSQFPLLVSDVSLQQQQSVSGQAQQQQLKPNSAAAIAANHNYSLHPASTAIITAQATPQQANKIFLTSSNSGGGGSAGNFTIATASELQAAAAGQKLHYKELPNSNLKLNFVSSAGTGEQTQQVGATTVLLNKSQQQQQQQQHQKLKTLATTGNSQTGQGDKRVLYTSLLNVKPLQKNNSGQMQMQLGPGGLQQVLRGRLNNSAIITRTLPLGTTVNSTGGAVGPTTTTIRQLVTTNANNVSSQDGNLLSAKEVGKALTVEQVIASANNGGVVLPTSNNNNNNNGSGAGGNGGPLNSGVNATGAGGGGSTGAGVGGAGVTSTINRXDADGSGSNSXHRAQPLQVPNGPLLSLASTQTEAETQAVAISMPLADAHVALGQLLQQHHCSCTVCLVNKSELV
Protein: PR domain zinc finger protein 2 (EC 2.1.1.355) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) (Q63755)
Organism: Rattus norvegicus (Rat)
Function: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MHQNTESVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRRGKKKSHENKNKGIRTHPTQLKASELDSTFANMRGSAEGPKEEDERPLASAPEQPAPLPEVGNQDAVPQVAIPLPACEPQPEVDGKQEVTDCEVNDVEEEELEEEEELEEEEEEELGEDGVEEADMPNESSAKEPEIRCEEKPEDLLEEPQSMSNEAREDSPDVTPPPHTPRAREEANGDVLETFMFPCQHCERKFATKQGLERHMHIHISTINHAFKCKYCGKRFGTQINRRRHERRHETGLKRRPSMTLQSSEDPDDGKGENVTSKDESSPPQLGQDCLILNSEKTSQEVLNSSFVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPSQNVYVPSTEPEEEGETDDVYIMDISSNISENLNYYIDGKIQTNSSTSNCDVIEMESNSAHLYGIDCLLTPVTVEITQNIKSTQVSVTDDLLKDSPSSTNCESKKRRTASPPVLPKIKTETESDSTAPSCSLSLPLSISTAEVVSFHKEKGVYLSSKLKQLLQTQDKLTLPAGFSAAEIPKLGPVCASAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPNDGKAAWTDTVLTSKKPKLESRSDSPAWSLSGRDERETGSPPCFDEYKISKEWAASSTFSSVCNQQPLDLSSGVKQKSEGTGKTPVPWESVLDLSVHKKPCDSEGKEFKENHLAQPAAKKKKPTTCMLQKVLLNEYNGVSLPTETTPEVTRSPSPCKSPDTQPDPELGPDSSCSVPTAESPPEVVGPSSPPLQTASLSSGQLPPLLTPTEPSSPPPCPPVLTVATPPPPLLPTVPLSHPSSDASPQQCPSPFSNTTAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSFPSSSCSSTSPSPPPLSAVSSVVSSGDNLEASLPAVTFKQEESESEGLKPKEEAPPAGGQSVVQETFSKNFICNVCESPFLSIKDLTKHLSVHAEEWPFKCEFCVQLFKVKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDEVCTHHEFESGTLRPQNFTDPSKANVEHMPSLPEEPLETSREEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLSFNVELGKMSPNKLKLSALKKKNQLVQKAILQKNRAAKQKADLRDTSEASSHICPYCDREFTYIGSLNKHAAFSCPKKPLSPSKRKVSHSSKKGGHASSSSSDRNSSCHPRRRTADTEIKMQSTQAPLGKTRARSTGPAQASLPSSSFRSRQNVKFAASVKSKKASSSSLRNSSPIRMAKITHVEGKKPKAVAKSHSAQLSSKSSRGLHVRVQKSKAVIQSKTALASKRRTDRFIVKSRERSGGPITRSLQLAAAADLSESRREDSSARHELKDFSYSLRLASRCGSSTASYITRQCRKVKAAAATPFQGPFLKE
Protein: RCC1 and BTB domain-containing protein 2 (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor) (Regulator of chromosome condensation and BTB domain-containing protein 2) (O95199)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q99LJ7}. Note=Mainly found in the acrosomal cap region. {ECO:0000250|UniProtKB:Q99LJ7}.
Interaction partners:
- Lysophosphatidic acid receptor 6
Sequence:
MEEELPLFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN
Protein: Snake venom vascular endothelial growth factor toxin IC1 (svVEGF) (Increasing capillary-1) (VEGF-F) (P0CJ33)
Organism: Macrovipera lebetinus (Levantine viper) (Vipera lebetina)
Function: Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein induces vascular permeability through VEGF receptor (KDR/VEGFR-2) signaling. May also induce angiogenesis through VEGF receptor (KDR/VEGFR-2) signaling.
Subcellular location: Secreted {ECO:0000269|PubMed:19695228}.
Interaction partners:
Sequence:
EVRPFPEVYERIA
Protein: Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (O55043)
Organism: Rattus norvegicus (Rat)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
Subcellular location: Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
Interaction partners:
- ARF GTPase-activating protein GIT1
- Serine/threonine-protein kinase PAK 3
- ARF GTPase-activating protein GIT2
- Cell division control protein 42 homolog
- Paxillin
- Serine/threonine-protein kinase PAK 1
- Protein scribble homolog
- NCK adaptor protein 1.
- Proto-oncogene tyrosine-protein kinase Src
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Protein: Auxin-responsive protein IAA2 (Indoleacetic acid-induced protein 2) (P49678)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin response factor 7
- Auxin response factor 5
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin transporter protein 1
- Auxin-responsive protein IAA4
- Auxin-responsive protein IAA1
- Auxin response factor 19
- Auxin response factor 1
- Auxin response factor 8
- Auxin-responsive protein IAA3
Sequence:
MAYEKVNELNLKDTELCLGLPGRTEKIKEEQEVSCVKSNNKRLFEETRDEEESTPPTKTQIVGWPPVRSSRKNNNSVSYVKVSMDGAPYLRKIDLKTYKNYPELLKALENMFKVMIGEYCEREGYKGSGFVPTYEDKDGDWMLVGDVPWDMFSSSCKRLRIMKGSDAPALDSSL
Protein: Probable acyl-CoA dehydrogenase (Q9I3H8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- 3-ketoacyl-CoA thiolase
- acetyl-CoA C-acyltransferase
- Geranyl-CoA carboxylase, beta-subunit
- Probable acyl-CoA thiolase
- glutaryl-CoA dehydrogenase
- Methylcrotonyl-CoA carboxylase, beta-subunit
- Biotin carboxylase
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
- Biotin carboxylase
- Probable 3-hydroxyacyl-CoA dehydrogenase
Sequence:
MTDFQQYFDESHQLIRDSVRRFVEREVLPYIDEWEEAEEFPRELYLKAGAAGILGIGYPEAYGGSCEGDLFAKVAASEELMRCGSGGLVAGLGSLDIGLPPVVKWARPEVRERVVPAVLRGEKIMALAVTEPSGGSDVANLKTRAVRDGDHYRVSGSKTFITSGVRADYYTVAVRTGGEGFAGISLLLVEKGTAGFSVGRKLKKMGWWASDTAELFFDDCRVPAENLIGVENAGFACIMANFQSERLALAVMANMTAQLALEESLRWAREREAFGKPIGKFQVLRHRLAEMATQLEVSREFTYRQAAKMAAGKSVIKEISMAKNFATDVADRLTYDAVQVLGGMGYMRESLVERLYRDNRILSIGGGSREIMNEIIGKQMGL
Protein: GH26090p (Q8T0K4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRDEVYLDNQLYFQGVQRKSSVPEAEELKIVESSESIQSQELEKVLKEENIDAEDEAFFETLPLIEEHINEVVANYGRDEKLLPQERKHNSIEEEQFEDALFEEPQKCVSDEVDAKNIEEILTDRSQNQTPNGSAETTDSGTPSQNKPYVHPPIDPFLLVLSASASAPDPFMPERPRPMSPREMRETLEEIKHSFRAQLEAEPSVSASPSPSLRPKANHGKGRAPPPPLPPKKHSLSPQPDAISQTSTGSVERKSGIGQLFKNIKANVLRNKANPSQQQPEDEQLAAKETQI