wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized zinc transporter P8A3.03 (Q9UT11)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Imidazoleglycerol-phosphate dehydratase
Sequence:
MFLLQRFFIYGLFLACFYTTVFGEKHFEAEEYRDSFLSQENMNKINHTTIERLFREMTENDPSLLSSSKTLAELSKGELAKAREDLKSVLSFLKNNLPVDTESSSEAFTIEKDNNSCVWLNSVKSFVEKQFSYSSGTNGILATFLTAIPPNIFILLVPKSFDTSMLNLFVAVSAGSLLGDVFLQLLPTVYSTNGGDFPASSVYSILIGALVFFLMDKGIRILIHERPSSLSKPKKDGEETSSVNKPSASSTQTDVKGVEGLRKRNVKDDQNSKGHEPDLIRHVVEEVSEEYNDKTVVYLNLLCDSFHNFMDGLAITSAFFTNTSIGISTTFAVLLHEIPAEIGDLAILLRNGYTKSQVLVLQMITMVTGLLGAIVATYIYTASSSSSPYGSFLLQLEDKLLPFTAGGFLYIAYLGVFPELLEINLSKGKLGNMIYTALYMMFIVGGFSFLYYV
Protein: Insulin receptor substrate-3 (O08724)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKPAGTGPTVSSGGESTDVSLGPPFPWPCPPDVRLCGHLRKQKSQRRRFFVLRADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLIVIYTSDSSLGVAAASEAEQQTWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQDVWPVTLRSKGLGRAPGLSSGSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSLLSVRRCGHADSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSSAASGKAEAPLGDSPKGASAVPAPAPYEIPALALAAQARSPGERAKQDYVNPLERMGSAPSYRGPDLGGDYIAMGMRNDYVHMGGKAAEYMWMAPPGLPPPTPPRVDPRKEPEDCESTEYMPMNRFLPGPLYYEFKAREPEHGHSSAQCSIRDRWRPMVAQPRSSQGSELSGDYMYIPDYPSARLGSLDSCLNYVDLDLVPPLEVPGAAPGNSPHSYASIKF
Protein: Protein cortex (Q960N3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Required for the completion of meiosis in oocytes. Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis. Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation. Promotes degradation of mtrm at the oocyte-to-embryo transition.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11252055}.
Interaction partners:
- Cell division cycle protein 27 homolog
- Cell division cycle 16
- Shattered
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 5
- Cyclosome subunit 8
- Mitotic spindle assembly checkpoint protein MAD2A
- G2/mitotic-specific cyclin-B
Sequence:
MFVEMSVCDSPNKNSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQEVSYVGERFIPNRFERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIGERRLFQFSSQQGTRSRVVDNDSADSDWPCNPRARPYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLWRNLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSMGYISCIEWSHDGKEVICGTQCGVIIVLAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFIFDAVLKVRLLKLDGRSIVFDWHPWTGEDLAVAERSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILVLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTYKREAILRKQEQKAKDKCSSLSLYKGIR
Protein: 4-chlorobenzoyl coenzyme A dehalogenase-2 (4-CBA-CoA dehalogenase-2) (4-CBCoA dehalogenase-2) (4-chlorobenzoyl-CoA dehalogenase-2) (EC 3.8.1.7) (Q9LCU3)
Organism: Arthrobacter sp
Function: Dehalogenates 4-chlorobenzoyl-CoA, 4-iodobenzoyl-CoA, 4-bromobenzoyl-CoA and, at a slower rate, 4-fluorobenzoyl-CoA. Does not dehalogenate 2-chlorobenzoyl-CoA or 3-chlorobenzoyl-CoA.
Interaction partners:
Sequence:
MSSNSDHHISVEHTDGVATIRFTRPSKHNAASAQLLLETLEALYRLESDDSVGAIVLTGEGAVFSAGFDLEEVPMGPASEIQSHFRLKALYYHAVIHMLARIEKPTLAAINGPAVGGGLGMSLACDLAVCTDRATFLPAWMSIGIANDASSSFYLPRIVGYRRAMEWLLTNRTLGADEAYEWGVVNRVFSEADFQSRVGEIARQLAAAPTHLQGLVKNRIQEGSSETLESCTEHEVQNVIASVGHPHFAERLAMFRSKEMRSSALAVDLDAVCGGR
Protein: Transcription initiation factor TFIID subunit 11 (TBP-associated factor 11) (Q9US54)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex/transcription factor TFIID complex subunit Taf9
- Transcription initiation factor TFIID subunit 13
- SAGA complex/transcription factor TFIID complex subunit Taf6
- Transcription initiation factor TFIID subunit 2
- SAGA complex/transcription factor TFIID complex subunit Taf10
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 4
- TATA-box-binding protein
Sequence:
MKRTGSASSVPRFQRSMSYDQSNSPTAGAHAKANTASPAAEPAPSSKEKENWNRQEENDLEEDDRDDFGTAAISKVAGKPGETDDEANEKLRTKYLLESFDEEQMQRYEVFRRANLNKTNVKKLANQILNQSVTPNVAIVISGFSKVFVGEIVELARKIQDQWGDTGPLSPDHLREAYRLSRQNRRLYPQSRHVSHLFR
Protein: C-type lectin PAL (CTL) (BaL) (Galactose-specific lectin) (Q9PSN0)
Organism: Bitis arietans (African puff adder)
Function: Galactose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids. This is a calcium-dependent lectin. Shows high hemagglutinating activity (MHC is 0.25 ug/ml on rabbit erythrocytes).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
NNCPPDWLPMNGLCYKIFDELKAWEDAERFCRKYKPGCHLASFHQYGESLEIAEYISDYHKGQAEVWIGLWDKKKDFSWEWTDRSCTDYLTWDKNQPDHYQNKEFCVELVSLTGYRLWNDQVCGSKNAFLCQCKF
Protein: Signal recognition particle protein (EC 3.6.5.4) (Fifty-four homolog) (Ffh) (p48) (P0AGD7)
Organism: Escherichia coli (strain K12)
Function: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Subcellular location: Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Interaction partners:
- Signal recognition particle receptor FtsY
- Protein translocase subunit SecY
- Protein translocase subunit SecE
- Protein-export membrane protein SecG
- Membrane protein insertase YidC
- Protein translocase subunit SecA
- Large ribosomal subunit protein uL23
- Sec translocon accessory complex subunit YajC
- Protein-export protein SecB
- Large ribosomal subunit protein uL29
Sequence:
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
Protein: SD08659p (Q8T987)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCNNNNNNNRDCGHRSRLDKMAENGFHYKSASAVPGTTVCCDNNNEASNPHPEPNYNSLKLKRSSAPAHSRPKSMHKLFKSISLRVGDNGNANGNGKGNGNAAILHHQQSLGGQPSGFTCVCCEEVTEIRTENPKRRNSFLKELKKRRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQYFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQGPMNCVVDAAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGDCRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPLSTKNK
Protein: Arginine decarboxylase 1 (ARGDC1) (OsADC1) (EC 4.1.1.19) (Q9SNN0)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
- Arginase 1, mitochondrial
- Os04g0466600 protein
- Os11g0708600 protein
- Spermidine synthase 1
- Putative nitric oxide synthase
- thermospermine synthase
- Aminopropyl transferase
- Os02g0254700 protein
- Arginine decarboxylase 2
- Os03g0825000 protein
Sequence:
MPALAVDAAAPVAHAFACDAARFPAPLLGPAAAAAAVAEKPDAAAWSADLSSALYNVDGWGAPYFFVNDDGDVAVRPHGAATLPGQEIDLAKVVAKAAGPRSGGGLGLPLPLLVRFPDVLRHRVEALNAAFDYAVRSTGYGGRYQGVYPVKCNQDRHVVEDIVEFGEPFRFGLEAGSKPELLLAMSCLAARGNPDALLICNGYKDDEYVSLALIARTMGLNTVIVLEQEEELDIVVDASRRLGVRPVVGMRAKLRTKHAGHFGSTSGEKGKFGLNAAQILSVVAKLKTLGMLDCLQLLHFHIGSQIPTTALLGDGVGEAAQIYCELARLGAAMRVIDVGGGLGIDYDGSHSAQTDMSVAYSLEEYAAAVVAAVGRVCDRKGVAHPIICSESGRALVSHHSVLVFEAFSASAPGRIDPATGYLLDELTDDCHADYRNLMAAAVRGDFDTCALYADQLKRRCADQFKDGVLGLEHLAAVDSLCEIVARGMGAAEPPRTYHINLSVFTSLPDMWAIGQMFPIIPIQRLGERPAVDGVLSDLTCDSDGKVDHFIGGRHSLPLHELPVHGTRGYYLGMFLGGAYQEALGGLHNLFGGPSVVRVSQSDGPHCFAVTRAAAGPSCADVLRSMQHEPEVMFEVLKQRTDGATAAALARAFGAMPYLSFDPEAAAMASGESSGMSSDSEGSAAGAAEEDDDEWEFMRGLTV
Protein: Olfactomedin-like protein 3 (HNOEL-iso) (hOLF44) (Q9NRN5)
Organism: Homo sapiens (Human)
Function: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
Subcellular location: Secreted {ECO:0000269|PubMed:15280020}.
Interaction partners:
- Transmembrane protein 119
- P2Y purinoceptor 12
Sequence:
MGPSTPLLILFLLSWSGPLQGQQHHLVEYMERRLAALEERLAQCQDQSSRHAAELRDFKNKMLPLLEVAEKEREALRTEADTISGRVDRLEREVDYLETQNPALPCVEFDEKVTGGPGTKGKGRRNEKYDMVTDCGYTISQVRSMKILKRFGGPAGLWTKDPLGQTEKIYVLDGTQNDTAFVFPRLRDFTLAMAARKASRVRVPFPWVGTGQLVYGGFLYFARRPPGRPGGGGEMENTLQLIKFHLANRTVVDSSVFPAEGLIPPYGLTADTYIDLAADEEGLWAVYATREDDRHLCLAKLDPQTLDTEQQWDTPCPRENAEAAFVICGTLYVVYNTRPASRARIQCSFDASGTLTPERAALPYFPRRYGAHASLRYNPRERQLYAWDDGYQIVYKLEMRKKEEEV
Protein: RE01132p (Q86PC0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSAVPVAIKTEEVILEHAEYNSAEELDEELQLQLEDSGGENYHIEFASESAHQGSQRRQSSMSGTNTSKGGGGGGSGALSDGDGSGKPLVDSEKRMRREIANSNERRRMQSINAGFQSLRSLLPRHEGEKLSKAAILQQTFQYIVELENQKTQLLTQNSELKRQVGEHEAGGSGDGGGTNSGGNYNDSNASGGNSTAVAIKKRKLTDNVINIQAISDSSDEGLGSMSPEPMTLLTAGGAAATKLSNAATLLAAKELHESKKQLEKERSLRRLLEDELQMIKRQLYSVATAPPGTAVAAASGGSSGAYIPREVIEHTDNFVRSEDLEELGGTVSYVEIDEMTGQQQVVVCSSIEELEADAAAEIITEDQVHEEVILSSNSSTESENEVNVNAIAKAYAEGCTSSAAMLQPILQAAIKATPKVEVERIHEKIVKVKTEKHDLPSMQTAPHYQHSHRQNLETIVQPSGIWRAITYSRTAVGAKKSLASSRISSSITTKCLEFTTSSCNTIVWRRMRRWPSPPRASSMRRWRSFDPSFNSRAAATSR
Protein: Forkhead box protein I1-A (FoxI1-A) (FoxI1a) (xFoxI1a) (Fork head domain-related protein 2) (xFD-2) (xFD2) (Q91904)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the non-neural versus neural cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:8735935}.
Interaction partners:
Sequence:
MNPVQQPAQHKCPASSLNPPHPKRAQEAPDMGLYCDNFMYQQHNLHPSHRATNFSIGDFTHQANPYLWLGGPGVNNSPSYSPTPAPYIPPAFSAPQRQFLANSAAFGGADLGWMSAASQEELLKRVRPPYSYSALIAMSIQNATDKRLTLSQIYQYVAENFPFYKKSKAGWQNSIRHNLSLNDCFKKMPRDENDPGKGNYWTLDSNCEKMFDNGNFRRKRKPKSETNNIKIAKREEDHVSPKGKESPPMITPSSPKELSPTGHSKCPSPPTVTYTPCLTNFIGSMTAVDSATMNRQGPLGLLNELSQRNLNGLSSFISGSAVDQSPEHQDSSLFYNRSPYYSSLPTSNQKQPPYLQQLHPQQSPLYQGRY
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (H3BV22)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRA
Protein: Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (G3V5T9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}.
Interaction partners:
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Protein: Uncharacterized protein At3g28850 (Q9LH89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Camphor resistance CrcB family protein
- Protein S-acyltransferase 8
- Serine/threonine-protein kinase PBL34
- Protein DETOXIFICATION 34
- Urea-proton symporter DUR3
- Cytochrome b561 and DOMON domain-containing protein At3g25290
- Pollen receptor-like kinase 6
- Calcium-dependent protein kinase 8
- Probable inactive receptor kinase At5g58300
- Pollen-specific leucine-rich repeat extensin-like protein 3
Sequence:
MGCASSKHRKRCLHCRRGYSPPVDVQRSHSVHHASQNSEDSCHMVALSSSSLGSLKLCDSSFGHNHKHLADFSEKLVSGESVKTGNGFGPNVVREKSDKEKSNLELQAKLMEAKVWSSMMNEKIPKIVPKTPIVTPPGEPETINTWEMMDGLEDVLSPLRSPNHVKSFSFDVGPNGGKSNGSVKPVWLQMEEEEEGFEDFDPEIISSFRKSLQELPSDHPFHISNHDFELKPRFNFSDEEKEEEEQSVGKERVILYFTSLRGIRKTYEESCDVRVILKSLGIRVDERDVSMHSGFKDELKELLGEKFNKGVGITLPRVFLGRKYIGGAEEIRKLNEDGKLEKLLGGCERVEENQNGNGLECEACGDVRFVPCETCSGSCKVYYEYEDDDDDDDEGDDDESVKEEREYGFQTCPDCNENGLIRCPVCCD
Protein: Semaphorin-3E (O15041)
Organism: Homo sapiens (Human)
Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Plexin-D1
- Neuropilin-1
- Neuropilin-2
- Plexin-A3
- Chromodomain-helicase-DNA-binding protein 7
- Plexin-A1
- Plexin-A4
- Vascular endothelial growth factor receptor 2
- Plexin-A2
- Plexin-C1
Sequence:
MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDRKRKKLKMSPSKWKYANPQEKKLRSKPEHYRLPRHTLDS
Protein: Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (A2APF3)
Organism: Mus musculus (Mouse)
Function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17048991}.
Interaction partners:
- Protein arginine N-methyltransferase 7
- Double-strand-break repair protein rad21 homolog
- Cohesin subunit SA-2
- Structural maintenance of chromosomes protein 3
Sequence:
MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK
Protein: FT-interacting protein 1 (Multiple C2 domain and transmembrane region protein 1) (Q9FL59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the export of FT from the phloem companion cells to the sieve elements through the plasmodesmata. Regulates flowering time under long days.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22529749, ECO:0000269|PubMed:29259105}; Multi-pass membrane protein {ECO:0000255}. Cell junction, plasmodesma {ECO:0000269|PubMed:22529749}. Note=Localized in plasmodesmata between companion cells and sieve elements. {ECO:0000269|PubMed:22529749}.
Interaction partners:
- Protein SODIUM POTASSIUM ROOT DEFECTIVE 1
- Protein TWIN SISTER of FT
- MADS-box protein SOC1
- Protein STRUBBELIG
Sequence:
MAAKDGAKSQEDYKLKDMKPELGERWPHGGQRGGTGWIGSERAASTYDLVEQMFYLYVRVVKAKDLPPNPVTSNCDPYVEVKIGNYKGKTKHFEKRTNPEWNQVFAFSKDKVQSSTVEVFVRDKEMVTRDEYIGKVVFDMREVPTRVPPDSPLAPQWYRLEDRRGESKKRGEVMVAVWLGTQADEAFPDAWHSDASSVQGEGVQSVRSKVYVSPKLWYLRVNVIEAQDVEPSDRSQPPQAFVKVQVGNQILKTKLCPNKTTNPMWNEDLVFVAAEPFEEQFFLTVENKVTPAKDEVMGRLISPLSVFEKRLDHRAVHSKWYNLEKFGFGALEGDKRHELKFSSRIHLRVCLEGGYHVMDESTLYISDVKPTARQLWKSPIGILEVGILSAQGLSPMKTKDGKATTDPYCVAKYGQKWVRTRTIIDSSSPKWNEQYTWEVYDPCTVITLGVFDNCHLGGSEKSNSGAKVDSRIGKVRIRLSTLEADRIYTHSYPLLVLQTKGLKKMGEVQLAVRFTCLSLAHMIYLYGHPLLPKMHYLHPFTVNQLDSLRYQAMSIVAARLSRAEPPLRKENVEYMLDVDSHMWSMRRSKANFFRIVSVFAGLIAMSKWLGDVCYWKNPLTTILFHVLFFILICYPELILPTTFLYMFLIGLWNFRFRPRHPAHMDTKVSWAEAASPDELDEEFDTFPTSKGQDVVKMRYDRLRSVAGRIQMVVGDIATQGERFQALLSWRDPRATCLFVIFCLVAAMILYVTPFKIIALAGGMFWMRHPKFRSKMPSAPSNFFRKLPSKADCML
Protein: Pentatricopeptide repeat-containing protein At5g39710 (Protein EMBRYO DEFECTIVE 2745) (Q9FIX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MFLTKTLIRRSLSTFASSPSDSLLADKALTFLKRHPYQLHHLSANFTPEAASNLLLKSQNDQALILKFLNWANPHQFFTLRCKCITLHILTKFKLYKTAQILAEDVAAKTLDDEYASLVFKSLQETYDLCYSTSSVFDLVVKSYSRLSLIDKALSIVHLAQAHGFMPGVLSYNAVLDATIRSKRNISFAENVFKEMLESQVSPNVFTYNILIRGFCFAGNIDVALTLFDKMETKGCLPNVVTYNTLIDGYCKLRKIDDGFKLLRSMALKGLEPNLISYNVVINGLCREGRMKEVSFVLTEMNRRGYSLDEVTYNTLIKGYCKEGNFHQALVMHAEMLRHGLTPSVITYTSLIHSMCKAGNMNRAMEFLDQMRVRGLCPNERTYTTLVDGFSQKGYMNEAYRVLREMNDNGFSPSVVTYNALINGHCVTGKMEDAIAVLEDMKEKGLSPDVVSYSTVLSGFCRSYDVDEALRVKREMVEKGIKPDTITYSSLIQGFCEQRRTKEACDLYEEMLRVGLPPDEFTYTALINAYCMEGDLEKALQLHNEMVEKGVLPDVVTYSVLINGLNKQSRTREAKRLLLKLFYEESVPSDVTYHTLIENCSNIEFKSVVSLIKGFCMKGMMTEADQVFESMLGKNHKPDGTAYNIMIHGHCRAGDIRKAYTLYKEMVKSGFLLHTVTVIALVKALHKEGKVNELNSVIVHVLRSCELSEAEQAKVLVEINHREGNMDVVLDVLAEMAKDGFLPNGIS
Protein: Complement C1q B chain (F1NH19)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Complement C1q A chain.
- Complement C1q C chain
- Calponin-homology
- Uncharacterized protein
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Uncharacterized protein
- Eukaryotic translation initiation factor 2 alpha kinase 4.
- complement subcomponent C1r
- Lymphocyte antigen 86
Sequence:
MQTVWVVLICLAGGQLASATLCKTYGTIPGIPGSPGQPGTNGRDGKNGPKGEQGPPGLVEHEQDMGEKGDPGEPGYPGKVGPRGLPGSKGLPGPMGPPGPRGDTGDYKVTLKSAFSAARTFSSFPRRDYPIRFDRIITNENRHYENRYGRFTCQVPGVYYFTYHVTSKGSLCLRMKKGRGGSRDEKVVTFCDYVQNSYQVTTGGVVLRLAANESVWLEPTEKNSIMGIEGADSIFSGFLIFPEV
Protein: AT5g11580/F15N18_170 (Regulator of chromosome condensation (RCC1) family protein) (Q93Z10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEDKSPTLLISEDLSRKIISLAAGEAHTIALTGDGCVYSWGRGMFGRLGTGKESDELVPVLVEFPNQAEGDRIRIVGVAAGAYHSLAVSDDGSVWCWGYNIYGQLGFDGENSLAPCLIKNLFERETSSSSLNDSGREVGSDLKVCTVKAGSMMSLAIDNVGGLWMWGNVPPQDSEPDPRLSFTSIPIPFPILDFHGRTVLKVACGDEHVVALVGPGDIHKDNSYDVSVLYSWGNNHHGQLGLGDGESRARPQTVETFNQKSGLTVYDIACGAHHTALLTYRKETPKGPSICWTFGFGENGQLGHRSNKSSSLPEPVSDLPEHAYLVSVDCGLFHTSVVSSEGYVWSWGMERGLGLCPDVNFTEVEAGDDSVPRKISGGSSRFRDPVQVSCGAAHTVLVVDGGYKLWSWGRGRNGVLGTGNVSDCYVPTLVFWPNELKPEKEEVPDDGKSASTEEIKRLESKLMVMERYASILHGSIFGKPFNEEEDIPYSLRVSGYFDMGKEWGEMLESADKSQLMRLQAFYEDMIGRVKDKVLQRRIQEIMKDCLQSSAPKY
Protein: Gastrin [Cleaved into: Big gastrin (Gastrin-34) (G34); Gastrin] (P01352)
Organism: Bos taurus (Bovine)
Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Subcellular location: Secreted.
Interaction partners:
- Gastrin/cholecystokinin type B receptor
- Cholecystokinin
- Promotilin
- Somatostatin
- R-spondin 1
- Noggin
- Pancreatic polypeptide prohormone
- Neurotensin/neuromedin N
- Pro-glucagon
- Secretin
Sequence:
MQRLCAHVLILVLALAAFCEASWKPHSHLQDAPVAPGANRGQEPLRMNRLGPASNPRRQLGLQDPPHMVADLSKKQGPWVEEEEAAYGWMDFGRRSAEEGDQHP
Protein: Calnexin (Q2UUH4)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
- Protein disulfide-isomerase
- Endoplasmic reticulum chaperone BIP
- Mannosyl-oligosaccharide glucosidase
- 116 kDa U5 small nuclear ribonucleoprotein component
- Mannosyl-oligosaccharide glucosidase
- Protein transport protein sec31
- E3 ubiquitin-protein ligase bre1
- C6 zinc finger domain protein
- Autophagy-related protein 22-2
- Autophagy-related protein 22-1
Sequence:
MRFNAAVASALVSSATLMGYAHAEEAEKNPDATSVVEKPTFTPTTLKAPFLEQFTDDWESRWTPSHAKKDDSQTEEDWAYVGEWSVEEPTVFKGIDGDKGLVVKNPAAHHAISAKFPKKIDNKGKTLVVQYEVKPQNSLVCGGAYLKLLQENKKLHAEEFSNATPYVIMFGPDKCGATNKVHFIFRHKNPKTGEYEEKHLKAPPAARTNKVTSLYTLIVRPDQSFQILIDGEAVKNGTLLEDFNPPVNPEKEIDDPKDKKPDDWVDDVKIPDPEATKPEDWDEEAPYEIVDEEATKPEDWLEEEPTSIPDPEAEKPEDWDDEEDGDWIPPTVPNPKCNDVSGCGPWSAPMKKNPAYKGKWTAPMIDNPAYKGPWAPRKIANPAYFEDKTPSNFEPMGAIGFEIWTMQNDILFDNIYIGHSPEDAEQLRKETFDVKHPVEVAEEEASKPKKEETAPATSVSFQEDPITFVREKVDHFVGLAKQDPVNAVKQAPEVAGTLGALVLSMVLIIVGAIKASSPAPAPVKKGKETAGAAKEKVSEAVSSSADTGKGGASKRTTRSSAQ
Protein: Uncharacterized protein (Q38ET9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVGSSFSSRHERRDMSPYSTRENLEAAPVPQRWSLLFVHRHMWRTKRRKVEENNVGGLHLTPSLELEEITDDGDVCLRCSQEEGTERDNSSENERSSSPVPVPLNSVNPQFRQADGAALPDGDVDTLGILPSLAHPVVLGKALDAIELVAKHVQHLHCTKCPLCGPPKPPTWWSTPRARRRLRREDNQVGIRSRADWEAGETSHNKENISSPSSLIGAVPQRRTVAASNTCCSHKDDVRRAHVLSKAEEFLQHIYDRRNRLIASRPLMYAVPAESHVLWRECSQLGGVALLEALLLGFTSQEVT