wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein YodD (P64519)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YebV
- Mannosyl-3-phosphoglycerate phosphatase
- Protein DsrB
- Universal stress protein B
- Uncharacterized protein YcgB
- Uncharacterized HTH-type transcriptional regulator YiaG
- Protein YjdN
- Probable protein adenylyltransferase Fic
- UPF0339 protein YegP
Sequence:
MKTAKEYSDTAKREVSVDVDALLAAINEISESEVHRSQNDSEHVSVDGREYHTWRELADAFELDIHDFSVSEVNR
Protein: Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) (Q9USQ7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (eft201 or eft202) to diphthamide (By similarity). Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Diphthine methyl ester synthase
- Diphthamide biosynthesis protein 4
- 2-
- Diphthine methyltransferase
- Elongation factor 2
- 2-
- Diphthamide biosynthesis protein 3
Sequence:
MKVLGLISGGKDSCFNLMHCVSLGHEVVALANLHPEDGKDEIDSFMYQSVGHDVIPLYAECFDLPLYREKIGGQSINQNLDYQFTEKDETEDLYRLIKRVLTNHPDLEAVSTGAILSTYQRTRVENVCKRLGLKSLSFLWQKDQEKLLNDMVVSGLNAILIKVAAIGLTRKDLGKSLAEMQDKLLTLNKKFELHPCGEGGEYETLVLDCPLFKKRIVLTDKEVVEHSSGEVCYLKVKACVKDKPEWQPISLKSELVPNEELLGEEYSHIYHTISKKYELIDDQEETPTSLIPIPLRESAFQQKKGSFLVLGNVVATKGSYNTFQGEAESAINNLNELLGTYGYSNKNVYFVTVILSSMSKFAEFNSVYNKYFDFTNPPSRSCVAAPLASEYRIVMSCIVGDVTEKRALHVQGQSYWAPANIGPYSQSICANGVVFISGQIGLIPSVMELKLHDKIFEMVLALQHANRVAKAMRVGSLIACLAYVCDSRDADCVVKIWSEYTKNTGESSPVLVALVDALPRNASVEWQLLYNDSSCDVPLLSSLVTNQTLFGSDTAWDVALLNQNGLRMESSFIHHEHPSAYAIVLNNAFPNSQLLHVRYTARDQNV
Protein: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) (Q06210)
Organism: Homo sapiens (Human)
Function: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling.
Interaction partners:
- Glucosamine 6-phosphate N-acetyltransferase
- Glucose-6-phosphate isomerase
- N-acetylglucosamine-6-phosphate deacetylase
- Glutamine--fructose-6-phosphate aminotransferase 2
- Glucosamine-6-phosphate deaminase 1
- Glutamine synthetase
- Glucosamine-6-phosphate deaminase 2
- Multifunctional protein CAD
- Mannose-6-phosphate isomerase
- Amidophosphoribosyltransferase
Sequence:
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
Protein: phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) (F1QAD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit beta)
- HRas proto-oncogene, GTPase a.
- Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3
- Erb-b2 receptor tyrosine kinase 3a.
- Vascular endothelial growth factor receptor 2
- Insulin receptor substrate 1
- Proto-oncogene tyrosine-protein kinase Src
- small monomeric GTPase
- Phosphatase and tensin homolog A
Sequence:
MPPRPSSGELWGIHLMPPRILVDCLLPNGMILTLECLREATLITIKHELFKEARKYPLHHLLQEETSYIFVSVTQEAEREEFYDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDLVKDPEVQDFRRNILNVCKDSVELRDASGAHSRALYVYPPNVESSPELPKHIYGKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQLKMCVQEYQGKYILKVCGCDEYLLEKYPISQYKYVRSCIMLGRLPNLMLMSKDSLYSQLPMDNFTMPSYSRRISTATPYMNGEASTKSLWTINSTLRIRVLCATYVNVNIRDIDKIYVRTGIYHGGEQLCDNVNTQRVPCSNPRWNEWLTYDMYIPDIPRAARLCLSICSVKGRKGAKEEHCPLAWGNVNLFDYTHTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDYFSSPVKFPDMATIEDHANWIISREMGYNYCQSGQSSRVARDHAMTEADIEQLRQLGNRDPLSEITEQEKDFLWRHRQYCVNIPEILPKILLAVKWNSRDEVAQMYCLLKDWPAIKPEQAMELLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDYMDALQNFTSPLNPAHQLGNLRLEDCRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSTTLHQWLKDKNKGEMYDMAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGGTQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIRHHAQN
Protein: Intermediate filament protein ifc-2 (G8JY94)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSTYAAYTTSTYQGRGLASGTYASGFGQLVSGMSSAGAICTTQIRDAREREKREIGLLNDRLADYIEKVRFLEAQNRCLSHDIDILRNGFSGGGHVSGLFDAEINQAKHILEQTTAHRSTFERDITGLSAEIEVFRKKWLDAVNAVKAHREDHDVDLDRLAKIEAEISLFKRKIRIVEEDVIRIRRENDGIYNEIARIKQLTHNEIALKNERSLNVSDLLQRINLLQTENNVRIEQELVFIRRDTTADNRDYFRHELQAAIRDIRADYEAISIRNRQDIEVWYREQIRKIQDESVRVNPDLYKEELISIRTTVTNVRSRLAEVEGRNFFLERLIDDLKNNEEAKFFEISLAERDAQIATLRDQCTELSIQMEKLCDNEISLRAEIERYRILLNGANVTTYTSNTHGSGSGIAVGGVVGGSTRVISQTTRTHSSSNTSYSNVPASRGGYSISGNVGGISVGGTIGSHGASAHATGGIIGSGVQAHRGSVSSLITDKPRDRVHDEKGVDQSGRHFHSWYLGTISINQVTPSYIELKNICKIRRVDVGGFRIEQSVNGQVLGSAQINVPLILDPQEVVRFNHRHGKYLGQFFMDVDAFDNSTVARTSMYNYTEPHEERAWFVYLD
Protein: UL14 (U5TQC3)
Organism: Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Virion tegument {ECO:0000256|ARBA:ARBA00004535}.
Interaction partners:
Sequence:
MDRDAAHAALRRRLAETHLRAEIYKDQTLQLHREGVSTQDPRFVGAFMAAKAAHLELEARLKSRARLEMMRQRATCVKIRVEEQAARRDFLTAHRRYLDPALGERLDAVDDRLADQEEQLEEAATNASLWGDGDLAEGWMSPADSDLLVMWQLTSAPKVHANGPSRIGSHPTYTPTPMGPPGAPAAPLSRTPPSPAPPTGPATDPASASGFARDYPDGE
Protein: Prohibitin (Q4FKP3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|RuleBase:RU366048}.
Interaction partners:
- Prohibitin
- Mitochondrial processing peptidase, beta subunit, putative
- Mitochondrial processing peptide beta subunit, putative
- Elongation factor TU, putative
- Mitochondrial processing peptidase alpha subunit, putative
- tetrahydrofolate synthase
- Stomatin-like protein, putative
- Mitochondrial ATP-dependent zinc metallopeptidase, putative
- ATP-dependent zinc metallopeptidase, putative
- Mitochondrial ATP-dependent zinc metallopeptidase, putative
Sequence:
MSRAPPPPDFSRIAAEIRKRLGNFGDIAGLTALVGFGGLVCAGLYKSIYFVDGGCCAVKFNAITGLKNRTYGEGANFAIPFLETPVVFDIRNKPTEVLTATGSRDLQTVNLAVRVLYQPHVSALPDIYRNVGMEYAETVLPSLVNEIIRAVIAQFNASDLLVKRPEVSNRIGVMLAERAKRFHIDITDVSITQMSFGKEYTSAVEAKQVAQQMAERAKWRVEQAEQEKEGAILLAKGEAEAAKLIGMAVQKNPAFITLRSLEASRTIADLMRQKGSGSFYIDSDTLSLNTQTIGH
Protein: Hexosyltransferase (EC 2.4.1.-) (Q57WM0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MSLSEPRKREFRQRSIARRSICATVLLLSLCTVAIYLTPRRDNGMKHREKAVMQVPSVRSHVVNVPSKYPLWIREALAYVPSTVLRQWEDAEYLVVFGVPSVDINVRRRRRHLQRMTCWAYGGVARRANDFVGSMLPLYILARHPDNNYVFTSAALEEAEKWNDVITLPMNEGRVSTKKQVGQDGKWGVEAEVGMSRKTFMWFDLSLIVFSRAAYIAKGDDDMFLRVPQYLVDLRDLPRRGVYWGTIDRYTVGRTRFNYAFGWCYTLARDVAKQFVSYGPLRKVVNSSSSVLSMFTIKRFYLLAEDAMVGLTLQRAGYASKILYIREKKCSFHSVRDGPDMFPVTDSSVMVHDIEEDSYSELKERFANERDVFSRFLYDPGDGVKTFDCS
Protein: Insulin receptor substrate 1 (E7F4P8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Insulin
- Tyrosine-protein kinase receptor.
- Insulin
- Growth factor receptor-bound protein 2
- Phosphatidylinositol 3-kinase regulatory subunit beta)
- Tyrosine-protein kinase receptor.
- Tyrosine-protein kinase receptor.
- Tyrosine-protein kinase receptor
- Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3
- Growth factor receptor-bound protein 2a
Sequence:
MASPTTEQGCFSDVKKVGYLRKPKSMHKRFFVLRAASASGPSRLEYYENEKKWRHKSGAPKRSIPLESCFNINKRADSKNKHLVALYTKDEYFAIAADSEIEQESWYEALVDLHNRGKVHETAPGRGVGEDNYGEATPGPAFKEVWQVILKPKGLGHTKNLIGVYRLCLTNKTISFVKLNSDAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMKAMSEEFRPRSKSQSSSNCSNPISVPVRRHHHNNPPPSQVGLGRRSRAESVTATSPVRPGKHSHSFRVRASSDGEGTMSRPASVDGSPSSPSNARPQSQRHRGGSRLHPPLNHSRSIPTPTSRCSPSAISPISLSSSSTSGHGSTSDCLFPRRSSASISGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPAREEEINNYICMAKPGSLPGAGSQSRSQSRGTPSRLEEPELEKCFRKRTHSSGASPPTPCHQKTPSQSPAASLEEYTVMMPTYPRSRSASSSSSTYRHSFMPTHSYPEEGTDASQAKDERGPDHKDDGYMPMLPGVAPATPTTKSSDYMPMSPKSVSAPQQIINPRQHSHVDSNGYMMMSPSGSCSPDGTTNYGKIWTNGINPKLSVESMEGKVSSCGDYINMSPASCSTTSTPPDCFFNPVEDPPRPMYAYYSLPRSFKHANRKQDQSPLRVSLGSSRLAYADSSSSSASSDSLGGQSNSQQSAVKPKRSEGNGRLTRPTRLSLDASKASTLPRTRESPFPPEPKSPGEYVNIEFNDKAFSASLASLFPPVYSVSDAEAPSDLSSSEYMNMQLGSQARRLCSELQTSSSSSDYAIITPSNSVSSPPLPCESICERDYISMQLASCTGFPDTQLMLMTEALPDADAPPCSVSPNHDVTTLSGAPGRPALISPLSGLSAFTRVNSTSGRNQGAKVIRADPQGRRRHSSETFASTATRGSVDTSSTCQSGDVKRHSSASFENVWLRPDQASAASTAPSASTVTNGRRETASGQIPTLTNHDQNGLNYIDLDLMQNGEQHVPDWNAFQSRPVELGAVEGIEELSAYASINFQKSDETRGNLTHREE
Protein: Homeobox protein Hox-D4 (Homeobox protein HHO.C13) (Homeobox protein Hox-4B) (Homeobox protein Hox-5.1) (P09016)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-D3
- Homeobox protein Hox-A5
- Homeobox protein Hox-B7
- Homeobox protein Hox-C4
- Homeobox protein Hox-C6
- Homeobox protein Hox-A7
- Homeobox protein Hox-B6
- Homeobox protein Hox-C5
- Homeobox protein Hox-B5
- Homeobox protein Hox-B4
Sequence:
MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL
Protein: Elongation factor Tu (EF-Tu) (EC 3.6.5.3) (P50062)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL11
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein bL9
- Small ribosomal subunit protein bS18
Sequence:
MAKEVFQRTKPHMNVGTIGHVDHGKTTLTAAISIYCSKLNKDAKALKYEDIDNAPEEKARGITINARHIEYETANRHYAHVDCPGHADYIKNMITGAAQMDAAILLVAADSGAEPQTKEHLLLAQRMGIKKIIVFLNKLDLADPELVELVEVEVLELVEKYGFSADTPIIKGSAFGAMSNPEDPESTKCVKELLESMDNYFDLPERDIDKPFLLAVEDVFSISGRGTVATGRIERGIIKVGQEVEIVGIKETRKTTVTGVEMFQKILEQGQAGDNVGLLLRGVDKKDIERGQVLSAPGTITPHKKFKASIYCLTKEEGGRHKPFFPGYRPQFFFRTTDVTGVVALEGKEMVMPGDNVDIIVELISSIAMDKNVEFAVREGGRTVASGRILEILE
Protein: Uncharacterized protein, isoform D (Q7KSN8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
Interaction partners:
- Pre-mRNA-splicing factor syf1 homolog
- Pre-mRNA-processing factor 19
- Cell division cycle 5, isoform A
- Pre-mRNA-splicing factor SPF27
- RE31520p
- Pleiotropic regulator 1
- Protein crooked neck
- 116 kDa U5 small nuclear ribonucleoprotein component
- Peptidyl-prolyl cis-trans isomerase E
- Puff-specific protein Bx42
Sequence:
MKRRSQTRAEQAVPPAKTTKENSGSLTVSQLSSDVIWQLASQYWTPDTKADHLPYSAKIIERIYNEEIGDGGGHSARRINMLEFSQYLEQYLWPHYQRETATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQYPAFFRHVLESCLPSKKAKEASSTLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELREVPEWRKYWKRLLKKEKDSKPEVLWERHFMQNLIIDFLHILESIPAEGEVPRNVVHYCERFLEFIIDLEALLPTRRFFNTVLDDCHLIVRALLSPLVRREEGKLFGQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKKITSLQRAVFAKFPSLRVFALSNVATVDNRESLEQHFGGLDGKGLLQIATFLNLVPEEVVSPLDWHRVDEQFLRELLITRHERRCSQLEALNEMPLYPTEQIIWDENVVPSEYYSGDSCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFAVVEVAKPHLGEKKPSRVRADVGVTLSVRREIKAEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQVGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDMDDLQEGADDVYESFNILMRRKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQERSLEFNDTFMDYNHLEASFPQYNLKCEVPVENRQPPFRLIFEDVPIQKESDGEDPEEKPEEKLTKSILVQPYKYEARGPYPSDKPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISNIYHNHPNQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAKRMDLLSQVQKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLVKEAKIIAMTCTHAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQHIFERDEYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKISILTTYNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAVGHLRDVRRLVVAMSRARLGLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSLVPEDKFPTDRLASAAVASQDIKTVENMSEMAQFVYERYMAKMEELKGTLPSEEELEAMRNQLLQEDEESVPEASEEPPEKRAAKEEPLSKKKTTEAFKPTPILNEINVDDTEMGQREQIEEEATDQDKTQESAPAEES
Protein: Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) (O14681)
Organism: Homo sapiens (Human)
Function: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:21154811}; Multi-pass membrane protein {ECO:0000269|PubMed:21154811}. Cytoplasm {ECO:0000269|PubMed:21154811}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Quinone oxidoreductase PIG3
- Ectopic P granules protein 5 homolog
Sequence:
MADSVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQRRRRASSVLAQRRAQSIERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTARIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTSAEKFPSPHPSPAKLKATAGH
Protein: SEC61 translocon subunit alpha 2 (SEC61A2 protein) (Sec61 alpha 2 subunit (S. cerevisiae), isoform CRA_d) (Q8TC24)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|RuleBase:RU003484}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003484}.
Interaction partners:
Sequence:
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNSARA
Protein: T. brucei spp.-specific protein (Q38FG4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAQCFGSDYVLGKAKPSDGERWNLLERVYADYEEMNAQQQEIAARKRELDMEFYDGNIEKIEEALHFNENRRGSREGDWDTYEKVEHIVKKFVYCRAGRVFKASEVQEVLEERIRLLGDIEASQKQRITALETTLSSVQSELAEVTRLLCMSEARAKALKAECVANTMKARQLQRVCDGLRGSGKKDESEVFRDMRLLIEANRQMEKDCQKLRVALNMGPVSAKKQKTVKAAQRVRARPVVAHSMSNSRNGSMVETLLTHTEKVGELKSEETLEANIESKADVVTDASQKQTKTLPQLTALTGDAEKSVSAAQSAVRADDGAPASVENSLVVCGGNGLCEVSLEGKPGDETLKFMSQPNITGSFPDLDQSQRDVSVSRTMSSKAIYKLERIQERASTLAEEVPLSDALMRAFIKCEKLQELMEWEVGRSMAMLDYDANVSHKHVSFHSACVGASKKFSQDASCGEERDMSMVFSGREVAGMPGESLNTSNSHLSPAAGASRTAVLQGSGVSPMSTLIGNQTSFFTTTQDATRTLTSLSGDLGHPLHSLMGQVLPNGLLTASQNSGYTEMSSAAARELAETGGGNVDFNDPGMPIQGMETSYKNGLLPHHAAVVLSTRKNLAVEDVGGLSTRIRTAALSGSDVSGASEGGWNQVGSREGSECSQLVYSSEDGDSDSETHHLGRWVDSPSQLSDEAPFEGVGVENANTRAKKYSARGSDRSNISFAGSRRSAHRSAASRLTSAATKGRTRNSTVSLATEQRLSARTKRRAARGGVKVNSAFRALSKEVSTLRDACHNMINEMNEMFDVMGKCVDALEKHSGTGQQVAATRTKQALSAVVKEVVKGVAEQEVLDRLGKQGIVLERHPESPNLTDEQWMQNRLYDAIMKSTSEHVDRALVQKGERPSKSLCGSRRSSLSALDQKQEGQERQRERERQRWQKQEEQCQGQDRLWKQGREQWQREGRGGGGGQWWEREEHMHASEPENVQRRLADLGKRRTPRQSGTNQGDSHFFSYPFRGDNELEDGSYTLWPSDPTPPTGVDTGVWEEPLEAMRREMWRLAGHPCVDSGDGNTEQNPRPLHAHMSKGGGGGWRERFSSWTVAGDAMFCAPLAEEGDRKYQPPVPYKTGPGFLVPRLRLGCARLGATHGAVRSNSCEEILEYLRRLQPPEYSRDLACLTPRVFRYDFGSTVSDARRNVREGVSQVKHHLQSALFNQGFSSEILPYATAARRLQHGGALPTWMREAVVMLRREEKDRNQKMAKLIFQKVATNIRTRSILKRVCRGSAFAAYLVVMWEKWMGGWEKRCEALRHTQKESLGRVMDMVVNGFNVVPQQLRGPLETQESPWVDARRTLKGASSYHFRDARIPSKDK
Protein: Epididymis secretory sperm binding protein (A0A384NQ21)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF
Protein: Chorionic somatomammotropin hormone 2 (Choriomammotropin) (Lactogen) (Placental lactogen) (PL) (P0DML3)
Organism: Homo sapiens (Human)
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
Subcellular location: Secreted.
Interaction partners:
- Chorionic somatomammotropin hormone 1
- Growth hormone receptor
- Somatotropin
- Chorionic somatomammotropin hormone 1
- Prolactin
- Prolactin receptor
- Erythropoietin
- Leptin
- Granulocyte colony-stimulating factor
- Thrombopoietin
Sequence:
MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF
Protein: G1/S-specific cyclin-D1 (P39948)
Organism: Rattus norvegicus (Rat)
Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P24385}. Cytoplasm {ECO:0000250|UniProtKB:P24385}. Nucleus membrane {ECO:0000250|UniProtKB:P24385}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250|UniProtKB:P24385}.
Interaction partners:
- Cyclin-dependent kinase 2
- cyclin-dependent kinase
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase inhibitor 1B
- Retinoblastoma-associated protein
- Cyclin-dependent kinase inhibitor 1C
- Glycogen synthase kinase-3 beta
- Cyclin-dependent kinase 4 inhibitor B
- Cyclin-dependent kinase 4 inhibitor C
Sequence:
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQREIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNIDPKATEEEGEVEEEAGLACTPTDVRDVDI
Protein: Probable NAD(P)H dehydrogenase (quinone) FQR1-like 1 (EC 1.6.5.2) (Q6NQE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of electrons from NADH and NADPH to reduce quinone to the hydroquinone state.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}.
Interaction partners:
- 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic
- Nitroreductase family protein
- Cytochrome c oxidase subunit 6a, mitochondrial
Sequence:
MATKVYIVYYSMYGHVEKLAQEIRKGAASVDGVEAILWQVPETLQEDVLSKMSAPPKSDAPIITPNELAEADGFIFGFPTRFGMMAAQFKAFLDATGGLWRTQQLAGKPAGIFYSTGSQGGGQETTALTAITQLVHHGMIFVPIGYTFGAGMFEMENVKGGSPYGAGTFAGDGSRQPTELELGQAFHQGKYIAAISKKLKGPAAA
Protein: Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) (P19246)
Organism: Mus musculus (Mouse)
Function: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22723690}. Cell projection, axon {ECO:0000269|PubMed:22723690}.
Interaction partners:
- Neurofilament light polypeptide
- Neurofilament medium polypeptide
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Alpha-internexin
- Kinesin light chain 1
- Kinesin light chain 2
- Kinesin-1 heavy chain
- Mitogen-activated protein kinase 14
- Kinesin light chain 3
Sequence:
MMSFGSADALLGAPFAPLHGGGSLHYSLSRKAGPGGTRSAAGSSSGFHSWARTSVSSVSASPSRFRGAASSTDSLDTLSNGPEGCVVAAVAARSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRAAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDEEARQREEAEAAARALARFAQEAEAARVELQKKAQALQEECGYLRRHHQEEVGELLGQIQGCGAAQAQAQAEARDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKESLERQRSELEDRHQADIASYQDAIQQLDSELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPSPFSLTEGLPKIPSISTHIKVKSEEMIKVVEKSEKETVIVEGQTEEIRVTEGVTEEEDKEAQGQEGEEAEEGEEKEEEEGAAATSPPAEEAASPEKETKSRVKEEAKSPGEAKSPGEAKSPAEAKSPGEAKSPGEAKSPGEAKSPAEPKSPAEPKSPAEAKSPAEPKSPATVKSPGEAKSPSEAKSPAEAKSPAEAKSPAEAKSPAEAKSPAEAKSPAEAKSPATVKSPGEAKSPSEAKSPAEAKSPAEAKSPAEAKSPAEVKSPGEAKSPAEPKSPAEAKSPAEVKSPAEAKSPAEVKSPGEAKSPAAVKSPAEAKSPAAVKSPGEAKSPGEAKSPAEAKSPAEAKSPIEVKSPEKAKTPVKEGAKSPAEAKSPEKAKSPVKEDIKPPAEAKSPEKAKSPVKEGAKPPEKAKPLDVKSPEAQTPVQEEAKHPTDIRPPEQVKSPAKEKAKSPEKEEAKTSEKVAPKKEEVKSPVKEEVKAKEPPKKVEEEKTLPTPKTEAKESKKDEAPKEAPKPKVEEKKETPTEKPKDSTAEAKKEEAGEKKKAVASEEETPAKLGVKEEAKPKEKTETTKTEAEDTKAKEPSKPTETEKPKKEEMPAAPEKKDTKEEKTTESRKPEEKPKMEAKVKEDDKSLSKEPSKPKTEKAEKSSSTDQKESQPPEKTTEDKATKGEK
Protein: RNA binding protein fox-1 homolog 2 (B0QYV1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037932}.
Interaction partners:
Sequence:
MVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY