wanglab/gogpt-training-data huggingface dataset:
Protein: Protein ste7 (Q10136)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in promoting meiosis whereby it is involved in establishing the mating pheromone signaling pathway. It also has a role in suppressing meiosis until the conjugation process is complete.
Interaction partners:
- Transcription factor ste11
- Sexual differentiation protein ste4
- Protein kinase byr1
- Protein kinase byr2
Sequence:
MFLEIILDSATYSFDRVITGKICFETNAATSPRSFQIQLRIKGYAVYHHGFLSSPSHKHPTTASASDSDEATEIFTHSQPLPIPAGPSSKSHAIDFKFKFPSKSASSLPCSKSNDSMVNICYMLKATISKRYAFLGSSQSAKAELIMVPPNLAGKPLSANSSFGSSAKTFQLPEFDSVTPSASLYKQPSFNSNPAPITTSSATHTSQFSTSSSSSVNSVHTPVMVPNPYFQYNSSMTAPSSSSSSVAPFVPRRQFSVSSASDPPQTPISMSPPIPPTPSQFSAFMYQNQQSYLSPQSHYENPLSISSRPSPCCPSTPSSAVTLSNGFDSQSNAYNNSGTGPPMLYKFPQRSYTAPNTSFNSQRRMSSITSLPTASFCPVKHGVSPPSLAGNQPSPLSSPLTNSNVSPSTICSPDNNVTFVNLAPGEKLTFKIEPNDLMDEEEVVENSNMYSIPGKTVATTVCHSSSSSGDFSALSCHRNLSFSESLPTAEDQVHNNHCAVSPSRRSSSNALYLATLPMGYERSNSVSYCSDSSLSSPLPDDNMLQDPHALNMAYAKEFDVLINEVLQSL
Protein: Binding protein (F4JC31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Serine/threonine-protein phosphatase 4 regulatory subunit-like protein
- Serine/threonine-protein phosphatase PP-X isozyme 1
- Serine/threonine-protein phosphatase PP-X isozyme 2
- Serine/threonine-protein phosphatase 2A activator
- Myb/SANT-like DNA-binding domain protein
- Phytochrome-associated serine/threonine-protein phosphatase 3
- Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
- At1g77350/F2P24_6
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Putative recombination initiation defects 3
Sequence:
MGAPEKSQSNTNSMQRVKVYHLNEDGKWDDRGTGHVSIDFVERSEELSLCVIDEEDNETLLVHPINPEDIYRKQEDTIISWRDPERSTELALSFQETAGCSYVWDQICTMQRNLHFSSLNSETFHSLNSELRELPAVELTTLPLILKIVTESGITDQMRLTELILKDHDFFRNLMGVFKICEDLENVDGLHMIFNIVKGIILLNSSQILEKIFGDELIMEIIGCLEYDPGVPHSQHHRNFLKEHVVFKERQSHVFFVRKEHAHYGCFGISAIPIKDPLVLSKIHQTYRIGYLKDVVLARVLDDAIVANLNSVIHANNAIVVSLLKDDSTFIQELFARLRSPSTSMESKKNLVYFLHEFCSLSKSLQVVQQLRLFRDLINEGIFHVIEEVLQIPDKKLVLTGTDILILFLTQDPNLLRSYVVRTEGNPLLGLLVKGMMEDFGDKMHCQFLEIIRTLLDANALSGGAQRANIMDIFYEKHLPELVDVITASCPEKSSNASEGAARRIFTKPEVLLNICELLCFCIMQDASRTKCSFLQNNVTEKVLHLTRRKEKYLVVAAIRFVRTLLSVHDDYVQNYVVKNNLLKPIIDVFIANGTRYNLLNSAVLDLLEHIRKGNATLLLKYIVDTFWDQLAPFQCLTSIQAFKVKYEQCLESAGPKSTSDAVDPRRRVDERALEKEEEDYFNEDSDEEDSASASNTQKEKPASNIQKEQPKPHLSNGVAASPTSSSPRSGGLVDYEDDEDDEDYKPPPRKQPEASEDEEGELLRLKRKSALVEREQEPSKKPRLGKSSKRENVFAVLCSTLSHAVLTGKKSPGPAGSAARSIVAKGAEDSKSSEENNSSSSDDENHKDDGVSSSEHETSDNGKLNGEESLVVAPKSSPEMAVNGS
Protein: Aquaporin PIP2-7 (Plasma membrane intrinsic protein 2-7) (AtPIP2;7) (Plasma membrane intrinsic protein 3) (At-PIP3) (Salt stress-induced major intrinsic protein) (P93004)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10737809, ECO:0000269|PubMed:15060130, ECO:0000269|PubMed:25082856}; Multi-pass membrane protein {ECO:0000269|PubMed:10737809}. Note=Trafficking from the post-Golgi compartment to the plasma membrane is mediated by the SNARE proteins SYP61 and SYP121. {ECO:0000269|PubMed:25082856}.
Interaction partners:
- Probable aquaporin PIP2-8
- Translocator protein homolog
- Syntaxin-121
- PAMP-induced secreted peptide 1
- Syntaxin-61
- Probable aquaporin PIP2-5
- Probable aquaporin SIP1-2
- Probable inactive receptor kinase At5g16590
- Probable aquaporin SIP2-1
Sequence:
MSKEVSEEGKTHHGKDYVDPPPAPLLDMGELKSWSFYRALIAEFIATLLFLYVTVATVIGHKKQTGPCDGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLVRALGYMIAQCLGAICGVGFVKAFMKTPYNTLGGGANTVADGYSKGTALGAEIIGTFVLVYTVFSATDPKRSARDSHIPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWDDQWIFWVGPFLGALAAAAYHQYILRASAIKALGSFRSNATN
Protein: Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26) (Q5U2N8)
Organism: Rattus norvegicus (Rat)
Function: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:22718903}. Note=Localizes at the transition zone in photoreceptor cells. {ECO:0000250|UniProtKB:Q8BS45}.
Interaction partners:
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport 88
- Intraflagellar transport 52
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 172 homolog
- TRAF3-interacting protein 1
- Intraflagellar transport protein 22 homolog
- Clusterin-associated protein 1
Sequence:
MMLSRAKPAVGGESPHTDKRKKKGRKIPKLEDLLSQRDFTGAITLLEFKRHVGEQEEDTNLWIGYCAFHLGDYKRALEEYENAAKEENCNPEVWVNLACTYFFLGMYKQAEAAGFKAPKSRLQNRLLFHLAHKFNDEKKLMNFHQNLQDIKEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSPFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEVFLLIQSEKLKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMILAGREPKETLREVLHLLRSTGNTQVEYIIRIMKKWAKENRVPI
Protein: Amphiregulin (AR) (Schwannoma-derived growth factor) (SDGF) (P24338)
Organism: Rattus norvegicus (Rat)
Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Subcellular location: Membrane; Single-pass membrane protein.
Interaction partners:
- Receptor protein-tyrosine kinase
- Pro-epidermal growth factor
- Proepiregulin
- Receptor tyrosine-protein kinase erbB-3
- Receptor tyrosine-protein kinase erbB-4
- Pro-epidermal growth factor
- Receptor tyrosine-protein kinase erbB-2
- Protransforming growth factor alpha
- Epigen
- Probetacellulin
Sequence:
MRTPSLSLALSVLSLLVLGSGHYAAGLELNGTSSGKGEPSSGDHSAGGLVVSEVSTISEMPSGSELSTGDYDYSEEYDNEPQISGYIVDDSVRVEQVIKPKENKTEGEKSSEKPKRKKKGGKGGKGRRNRKKKKNPCAAKFQNFCIHGECRYIENLEVVTCHCHQDYFGERCGEKTMKTQKKDDSDLSKIALAAIIVFVSAVSVAAIGIITAVLLRKRFFREYEEAEERRRLRQENGTAHAIA
Protein: Germ cell-less protein-like 1 (Spermatogenesis-associated protein 29) (Q96IK5)
Organism: Homo sapiens (Human)
Function: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).
Subcellular location: Nucleus matrix {ECO:0000250}.
Interaction partners:
- X antigen family member 2
Sequence:
MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFCYCAGSHKRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRDDVLIKPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINVMKQLIGSSNLFVMQVEMDIYTALKKWMFLQLVPSWNGSLKQLLTETDVWFSKQRKDFEGMAFLETEQGKPFVSVFRHLRLQYIISDLASARIIEQDAVVPSEWLSSVYKQQWFAMLRAEQDSEVGPQEINKEELEGNSMRCGRKLAKDGEYCWRWTGFNFGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSSGKLICSRTTGYQILTLEKDQEQVVMNLDSRLLIFPLYICCNFLYISPEKKN
Protein: Thymopoietin (G5E972)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
Protein: Serine and arginine repetitive matrix 1 (Serine/arginine repetitive matrix 1 isoform 2) (A0A0S2Z4Z6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS
Protein: Protein GCN20 (General control non-derepressible protein 20) (P43535)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a positive activator of the GCN2 protein kinase activity in response to in response to low amino acid, carbon, or purine availability. Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN20 helps GCN1 to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity. Participates in gene-specific mRNA translation activation, such as the transcriptional activator GCN4, by promoting the GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52', and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Interaction partners:
- eIF-2-alpha kinase activator GCN1
- eIF-2-alpha kinase GCN2
- Histidine--tRNA ligase, mitochondrial
- Eukaryotic translation initiation factor 2 subunit alpha
- Protein GIR2
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS19
- Translation initiation factor RLI1
Sequence:
MASIGSQVRKAASSIDPIVTDYAVGYFNHLSGITFDAVQSKQVDLSTEVQFVSDLLIDAGASKAKVKELSESILKQLTTQLKENEAKLELTGDTSKRLLDINVLKSHNSKSDINVSLSMLGVNGDIEHTGRKMETRVDLKKLAKAEQKIAKKVAKRNNKFVKYEASKLINDQKEEDYDSFFLQINPLEFGSSAGKSKDIHIDTFDLYVGDGQRILSNAQLTLSFGHRYGLVGQNGIGKSTLLRALSRRELNVPKHVSILHVEQELRGDDTKALQSVLDADVWRKQLLSEEAKINERLKEMDVLRQEFEEDSLEVKKLDNEREDLDNHLIQISDKLVDMESDKAEARAASILYGLGFSTEAQQQPTNSFSGGWRMRLSLARALFCQPDLLLLDEPSNMLDVPSIAYLAEYLKTYPNTVLTVSHDRAFLNEVATDIIYQHNERLDYYRGQDFDTFYTTKEERRKNAQREYDNQMVYRKHLQEFIDKYRYNAAKSQEAQSRIKKLEKLPVLEPPEQDKTIDFKFPECDKLSPPIIQLQDVSFGYDENNLLLKDVNLDVQMDSRIALVGANGCGKTTLLKIMMEQLRPLKGFVSRNPRLRIGYFTQHHVDSMDLTTSAVDWMSKSFPGKTDEEYRRHLGSFGITGTLGLQKMQLLSGGQKSRVAFAALCLNNPHILVLDEPSNHLDTTGLDALVEALKNFNGGVLMVSHDISVIDSVCKEIWVSEQGTVKRFEGTIYDYRDYILQSADAAGVVKKH
Protein: Autophagy-related protein 9 (A0A0B4KF86)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Preautophagosomal structure membrane {ECO:0000256|ARBA:ARBA00004511, ECO:0000256|RuleBase:RU364027}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004511, ECO:0000256|RuleBase:RU364027}.
Interaction partners:
- Autophagy-related protein 2
- Autophagy-related protein 13 homolog
- Autophagy-related 1, isoform B
- Autophagy-related 18a, isoform E
- Autophagy-related 18b, isoform A
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Autophagy protein 12-like
- Beclin-1-like protein
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy-related 14
Sequence:
MSSPHINYRSLAEEAASPFLEHHPSTGQGPSKTQDAKANAAAAHLDPLGEHGLEQPLDEHDTEHEGEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDEMLQVLEFGFVVWLLAFVMHCVRFDVLFGDTPPGGLNPNKTTLSDVMYPTGECLANFTWVTYLVVFIAAIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQHMCIDKESLTELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGPGSPFQNNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEPGALGLRTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFSSPLAAVIAKNLLFISGGLLLLILALGIYEEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWCPEQLMTAILAHVHYLPSEWRQQAHTTKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVCSFAQMDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKEAKQFLRGVREHAVGELVQAKTSMVQENPLTNSLISFGTMGADYCSIANSVLTAQVTPQQLEISQSLRPGLGPVSGGFPVAASDFRQMLQQNLSASVGPLDSMRRLRLSRAEGRLEGPTDTLLYGLCGVDPRVGSTPLNVGVADMCLSALYLHELNQQKRQARQSRIDEAEDERPGTSHWPPRPPAAPSADTGFGSRHTVITSKAAESTPLLGSIRSXQRPEWI
Protein: ArfGAP with dual PH domains 1 (A0A8I5ZRW6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MVQWGGGSLVLHGSHLPLSDLPFNMFGKAGYARVSGVPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWDETQVEFMTSHGNEAARATFESKVPPFYYRPTFSDCQLLREQWIRAKYERQEFLHVEKQEPYSTGYREGLLWKRGRDNGQFLSRKFVLTEREGALKYFNKNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLEGLPPSTQSHHWPHGITIVTPDRKFLFTCETESDQREWIAAFQKVVDRPMLPQEYAVEAHFKHKP
Protein: Basement membrane proteoglycan (H9G348)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKRSSTVLAALLALLLVATNDAARHRKYRQTYQDIDSDDDDTSDVQITVFPSEKEVRDGRDVSFECRARTSDNSVYPTVRWARVGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNTVEARATLSVVSYGPQEVSNGLRQAGQCMADEKACGNNECVKNDYVCDGEPDCRDRSDEANCPAISRTCEPNEFKCNNNKCVQKMWLCDGDDDCGDNSDELNCNAKPSSSDCKPTEFQCHDRRQCVPSSFHCDGTNDCHDGSDEVGCVQPTVVDPPQTNLQVPRGTTFSLTCKAVAVPEPYINWRLNWGPVCEPPRCLQTSEGGYGTLTIHDAQPVDQGAYTCEAINVKGRVLATPDCIVRVVDDPRPQPPQPPTAPPQRASCDTRGAVTPYPNNYGTCECKSQVTGPNCDQCKPGAFHLSEKSPEGCLKCFCFGVSNDCRSSGHYRTKDRLMFAGDAEGVTISDIEERTIDRNTPFSFFKTGYLTFDGTTDGVAKYWRLPQRFLGDKVTAYGGKMEFEIEFSGSGHHSSEPMVVLKGNQNILVHRVRNQEHVLRSDSPVRITVETYETNYEQLNGAAATREDLLMVLADLDAFLIRATHVAHQTSTSLGDVSWEIAVDRYTPDGLALEVEQCVCPPGYLGTSCEDCAPGYERSGYGPYLGTCVPIQPRHQQCGPGAVAPTAPAQGQCQCKASVIGPNCDRCAPNSFGLAPTNPQGCIPCFCSGVTQQCSASSYRRTSVSIDYARGDRDQLELTTSDSRQPYSPQTRAELSGQAIEFRSFEEARGQTLYWKLPEKFLGDKVTSYGGTLEYTFKFSGNGNSDQSADVILRGNDIALQYKHREPFYADRENKVQIKIIETSWQRVDGQQATREHLLMTLADLDTLLIKSTYNDDCTDSQLLSANLEFAEPYGQGLTAAEVEQCICPPGYVGTSCEDCAPGYSRTGGGLYLGLCEKCECNGHASQCDKEYGYCLDCQHNTEGDQCERCKPGFVGDARRGTPNDCQPEATRAPCHCNNHSPRGCDSFGRCLLCEHNTEGTHCERCKKGYYGDATKGSPYDCTPCPCPGASDCYLDNEGQVACRICPAGLQGRLCNECAPGYTRSNKPAGRVCEPIGQVTNEDITFVQKPHEVLRVRIMEPKRQIALPGDRVHWICQVTGYTTEKIHVEWTKVGEMSLPPNAKAYDGYLVLKGVEAENAGQYRCTATTITQYATDDALLTISKRISGRPPQPVIDPPHLVVNEGEPAAFRCWVPGIPDCQITWHREQLGGPLPHGVYQTGNALKIPQSQLHHAGRYICSAANQYGTGQSPPAVLEVKKPVIPPKVDPIRQTVDRDQPARFKCWVPGNSNVQLRWSRPGGAPLPSGVQEQQGILHIPRASDQEVGQYVCTATDPSDNTPLQSEPVQLNIRDPAPPQRGAAPQIDPPNQTVNVNDPAQFRCWVPGQPRAQLKWSRKDGRPLPNGILERDGFLRIDKSQLHDAGEYECTSTEPDGSTQLSPPARLNVNQPQAIQPQVDPPVQTVNEGEPSRIRCWVPGHPNIQLQFVKRGRRPLPAHARFSQGNLEIPRTLKSDEDEYICIATDPTTNRPVESNPARVIVKSRPPQHPVITPQTQTIPEGDPARIQCTVPGNPSAAQHLSFERVDGKGLPFGSSDDRGVLTIPSTQLQDAGEYVCLYSPENSPPVKTNPSTLNVTPEGTPPRPVATPPLLSVAPGSPARFNCVAHSDTPARIRWGFREENGPLPEHVNQDGDDIVISEAGDRNVGEYVCSATNDFGTGVADPVRLEVTEDQEPPTAVVEPRTWNGKPGERHQFRCITTGSPTPKITWTGPNGSPLPHDVTPLEPNILDFSNGRSELNGDYTCTASNPIGEASDHGNVNIGPSLTVKTNPPGPKLIVTVGEPLQVKCEAFGAPGDPEPEVEWLHDPGPERGDLPDDFKPVTISEQFIRHPNVGLGNAGVYTCKGSSAHATATKNIYIEVVEPSRIATVSILGGSSQWFDQGEKGELICTATGSSLVDRLEWEKVDDQLPTDVEEHNEPGLLHFPSFKNSYAGEYRCNGYRNNEIIASAAVHVHSSANADDEPKVEIEPPRVRVVSQGDNIVLKCSVQGAENGEHFKWALLRGGSLVRQLGTEPTLEITKADPSNDFGVYRCNVEDNNGLVIGSAFTAVSVGQQDKSHAQIVKFDDKSDASFTCPIYSVPGSKVDWTYENGDLPSKAVPNGNKIEIKEFDDASAGTYVCKVSFDGNVVEGFVTAQMFVPDTIIQVLLEVSSESPQIGDRAWFDCKVTGDPSAVISWTKEGNDDLPPNAQVTGGRLLFTDLKEDNAGVYRCVAKTKAGPLQTRTVLNVGSGKRKRKHLGNRRGRRLRHRRRNAQNGPLSRKTRTTTKLFGSWF
Protein: M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) (P48967)
Organism: Mus musculus (Mouse)
Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). May be involved in regulating the proliferation of T-lymphocytes following cytokine stimulation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P30307}.
Interaction partners:
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- 14-3-3 protein epsilon
- Serine/threonine-protein kinase Chk1
- Serine/threonine-protein kinase Chk2
- 14-3-3 protein zeta/delta
- G2/mitotic-specific cyclin-B2
- G2/mitotic-specific cyclin-B1
- Cyclin-dependent kinase 2
- 14-3-3 protein eta
Sequence:
MSTGPIPPASEEGSFVSAPSFRSKQRKILHLLLERNTSFTIRSDFPESPKDKLHDSANLSILSGGTPKCCLDLSNLSSGEMSASPLTTSADLEDNGSLDSSGPLDRQLTGKDFHQDLMKGIPVQLLCSTPNAMNHGHRKKIAKRSTSAHKENINTSLKALEWEAPRTPRFRKMPGGPLTSPLCELEMKHLGSPITTVPKLSQNVKLEDQERISEDPMECSLGDQDAKGLSLRKMVPLCDMNAIQMEEEESGSELLIGDFSKVCVLPTVPGKHPDLKYISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLHSQKELHEFFLRKPVVPLDIQKRVIIVFLCEFSSERGPRMCRSLREKDRALNQYPALYYPELYILKGGYRDFFPEYMELCDPQSYCPMLHQDHQAELLSWRSQSKAQEGERQLQGQIALLVKGASPQ
Protein: Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (P27674)
Organism: Bos taurus (Bovine)
Function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11166}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}.
Interaction partners:
- Cellular tumor antigen p53
- Solute carrier family 2, facilitated glucose transporter member 2
- Solute carrier family 2, facilitated glucose transporter member 4
- Basigin
- L-lactate dehydrogenase A chain
- Hypoxia-inducible factor 1-alpha
- Hexokinase-2
- Insulin
- Sodium/glucose cotransporter 1
- Neutral amino acid transporter B
Sequence:
MEPTSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVQRYGEPIPPATLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTELRGALGTLHQLGIVVGILIAQVFGLDSIMGNQELWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEESRQMMREKKVTILELFRSAAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLERLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
Protein: Ovomucoid (P68390)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Secreted.
Interaction partners:
Sequence:
VEVDCSRFPNTTNEEGKDVLVCTEDLRPICGTDGVTHSECLLCAYNIEYGTNISKEHDGECREAVPMDCSRYPNTTSEEGKVMILCNKALNPVCGTDGVTYDNECVLCAHNLEQGTSVGKKHDGECRKELAAVSVDCSEYPKPACTLEYRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC
Protein: Histone H1 (Q6FJX6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Could act as an H1-type linker histone.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
Interaction partners:
- Cyclin-dependent kinase 1
- Histone H4
- Candida glabrata strain CBS138 chromosome M complete sequence
- Histone H3
- Histone H3-like centromeric protein CSE4
- Negative regulator of the PHO system
- Histone H2A.1
- Histone H2A.2
- Importin-95
- Histone H2A
Sequence:
MAAKKVTKDTKPGYKNLIIEGLKALNNGKGASRVALKKYIKDNHSDVASVSLFDSYFNNAIKKGIDSKEFHFPKGPSGVLKLVKPASTSTTTKAKTTDKKVTKKSTASKASEKKTPAKKTATATTKKVTKPKKDEKKKTTQKKSSAITYREMILTGVLSMNNGKGASRMALKKFIKDKYPTNVEKVVNFDYLVNNAIKKGVESGELSQPSGPSGMVKILKKGKESIKSI
Protein: RNA-binding protein, putative (Q57YF9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- MIF4G domain-containing protein
Sequence:
MITPETAGTTSTVSQPQPTKRDSGSSIASVQLTSPASSEPPTQKGFTVEAASLTTANDIQMEKVTGTSSQSSETTAAHCWPLVNDGAGAAASTKSTLNPEAKEFHVPMGAVGFAVPAVPNPVDLHAMLQNPLLYCQPAPMTPMAMPWPPSRGGIANDGMIAPPEKNVAARWPASTPSVRVMASHDSSSGNSGSTAANTQNSVSQSPQSLTSQIMLAFASECSNYHIVAVFNLESRTTKEELLNIFFPMNAKKAEILPQHFSLRPNRRAGAVFFPSKAFAAVAVEKFNDFVPNGQHQPLRVIYCDPEAPPAQSLPVSPDATRSVTSMSGKQKQQQTQRTQQQPTWGLSSSAKPWRLPPGTELYKTHMEMCRFIQSNSHMNRASGKHVVAIHGLDPEVAHSVLSQNFIQKGAECFDMWPPKSCSFATTPMACSSVSALVYYNEEATAMEAVSLFQLKPPEGQAQPIDVVHLNKLFDFHPGGVALAGNQSVADVAGGNDTSATYSALHDTSNMAVLDEIDDFFKRTYSGRDLFLVGVHNLLATMDKKSLFALFSRYGALSAEIFPDIVQLSGGPRRSGLIFFDKEGTARDAAEKLNGSYAKGQLFPMVARYLSKPSGRDPVSGTAASEAAVESGTMLKPFRRNVASDVNDLCARVGNNALLREVVEELHANVVDVNVLTDKMQQLLTNPEATEKTAEQLATALTDTLIAFGHHAQALSTPLVNALLSLHEKMRIPRRGGRDNVGVENGEDPDLIMGRNIIFISKIARSLVHLFISNDKPDESRKVAAVLSAYLFQYCYLKKSPYELAVKIIKEHEVALRSAKEFERSRPLSTKPAVLFGAGKGEEDVHKPCLILLACLEEFTSLWRKNNKSRAKKDPYRKEYDHCLEGLLPLDSAQGGGNSSLCASARPTPRRVIEKVTPVNANGTSNSSPGLTYTSPSSHRVTTRGEPMDISSSHDVSVECASPHSATPVSLPHGDASTPSMFFRHCGSSAAMSLIQKQVQQQQQHLQQQQQQQHRASQVRPQLSEAATGLDSAKTFSGPRGGGYAPSVYTQAELMDRTVYITKLPSTLRRAQFRRLLTYFGELNKVRLCRDENQVPPKGDITGVGRNGSELGAPAPTLWFSFVEFAEPSSSKAIVEYFRNATFTSKPFSFLLDTPKGMPEASYFTVQDIQSLLNVRTSPARNPIHDQLSLDAVLTYSFPPVSVVCTEPCRFGIEHGEKTIDSAIDASPFSAFGSSCNMGLTPAARMRVTTKPLTDVQRHQPPVGTCGEQTKDADASDDDSLIEDIMDRGVKLAADRTYAKGSREMPHEASRHTTSFDSFVKEMCGKLGEADVREFAVFGDVSQQSMAPANALREKEPNNYSMIWGSHAFGEVLMDDGR
Protein: Small ribosomal subunit protein eS25 (40S ribosomal protein S25) (P62851)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Large ribosomal subunit protein uL24
- Ubiquitin-ribosomal protein eL40 fusion protein
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL24
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL2
Sequence:
MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA
Protein: Beta-toxin Ct16 (P0DUI1)
Organism: Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Function: Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity). Is possibly toxic to mice.
Subcellular location: Secreted {ECO:0000269|PubMed:23840487}.
Interaction partners:
Sequence:
MNYFILLFVATFLLLDVNCKKDGYPVDANNCKFECWKNEYCDELCKAKRAESGYCYKLKLSCWCEGLPDDEPTKTSDRCYGTGR
Protein: Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (P9WMP3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Interaction partners:
- Probable uroporphyrin-III C-methyltransferase HemD
- Delta-aminolevulinic acid dehydratase
- Glutamyl-tRNA reductase
- uroporphyrinogen-III C-methyltransferase
- Uroporphyrinogen decarboxylase
- Possible transcriptional regulatory protein
- Glutamate-1-semialdehyde 2,1-aminomutase
- Possible conserved transmembrane protein
- Coproporphyrin III ferrochelatase
- Possible transmembrane protein
Sequence:
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH