wanglab/gogpt-training-data huggingface dataset:
Protein: At5g03390 (Q9LZF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative F-box protein At5g55150
- Probable F-box protein At4g22030
- F-box protein At2g16300
- Putative F-box protein At4g22180
- Putative F-box protein At2g16290
- F-box/kelch-repeat protein At1g57790
- Probable F-box protein At1g65740
- DUF724 domain-containing protein 2
- DUF724 domain-containing protein 1
Sequence:
MSQLLGRTAKISSVVKKQRLCFSELRSFSTAATPYLLLKDTNYRAASGGSVVDINLYDPRKKEIVKIRDQYLSEELQCTMKMGSSRGWIVAKTIYEPTLYLTNIFNPCASVSSHKVFNLPPLEDDAKARISSISLSASPNQQDCVLAVKSSSSPFLSLWRPGDSAWTRIKVPFPASNVMMYSGRDRKFYLLPRESKEECEGPIDLINTSSDDFPQVTLYQRFPNSDIPVSRQEQLLSSIKTRYLVESPSGDSFIVYWCNERSFYWKKGEVKPWTGKNPPPSRISCRLKTRTFVVFRQDSEQGIGSYTEDIGDLCIFLGHREAFCVSATEYPGLRPNSVYYATSGTGFGYYDLSSNTLHDVIHEGLFSWIAPLQ
Protein: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (O09178)
Organism: Rattus norvegicus (Rat)
Function: AMP deaminase plays a critical role in energy metabolism.
Interaction partners:
- Adenine phosphoribosyltransferase
- Adenosine kinase
- Adenylosuccinate lyase
- Inosine-5'-monophosphate dehydrogenase 2
- 5'-nucleotidase
- Inosine-5'-monophosphate dehydrogenase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- Bifunctional purine biosynthesis protein ATIC
- GMP reductase 1
- Adenylosuccinate synthetase isozyme 1
Sequence:
MPRQFPKLNMSDLDEHVRLLAEKVFAKVLREEDSKDVMSLFTVPKDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSMSLQMPTQDWKGPPSVSPAMSPTTPLVLGAASKPGLAPYDMPEYQRATISGDYCAGITMEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLAHQGESVPLEEGLPDFHPPPLPQEDPYCLDDAPPNLGYLVRMQGGVLFVYDNQTMLERQEPHSLPYPDLETYIVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKYTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHGFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPSFGKMLENIFLPLFQATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALAD
Protein: Anaphase-promoting complex subunit 5 (Cyclosome subunit 5) (Q8MRX0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MILCLHFAGKSKIGFRGPKLTMNLFEELDTLDPSFKLEPPRIETPTAHKITVLILLKQYVINKKNCLDTGISMRTQRRRMFYMLVFKLIQEQDKSYNELHSLLTTGKYKLDTLMLESFEKAMSEFCAGSIEALFDFSEIQNIDEILNENYGISQFSMVGVYVRRVGVVLERLSFPEMMDMYKNVCSYYERGVRAAASGSRMAVAGGILHREETPPPNPITEKPEDPKPKKKVEAVARIAQERNPLSKWAPKQAKFFINKQSELLENNERKALPPLELQKKVQEIIHDLPLTTTPYFLGYMNQLRVRDYYNALSALHRALDRSPVRLMSQEKGYQYFCVNLAVLHATFGHRDEALAALRESIMLAQEHGDKRSLNLANTWYCLLRDELPLSAVQKSVQDANEVDGSLLQNYTLALHFAVKLGTVAGYQPLRLFDLLQHSDNLTNRNNFADHASEALALRSAVWSAYGRHELAALYSQVLLTGRDRFGSGSAGLGSALASFALWLQLQGEPQLSKVLLHHAKQRFPRLPSAEGWMISQCHVVIQAGIYQCRWHDALKACDQLYLIDPSDSLFQRASIYVAKREFFNARRLLDKLAVQDNIPFLLRMRVQVLLGYCGMANGRFSSETTMLLLRVSEEMSEAQMDYELALVDLLLAQQLLLLGMPQKAYQAIKRCMHDIHINGGLYERAKTDFVFVRCLLAVNQNDAEKRKAQLLKSQVILQRAAQSFKKLSAHAKVLDVYVFLAQRFNEFGDRNLRNKYAGEFRRYFTDHPIPREYLGSP
Protein: Myb1 protein (PfMyb1) (Q8IEF6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Transcriptional activator. Has a role in the parasite erythrocytic cycle where it directly regulates key genes involved in cell cycle regulation and progression. Binds directly to Myb regulatory elements.
Subcellular location: Nucleus {ECO:0000269|PubMed:15500927, ECO:0000269|PubMed:15663925}.
Interaction partners:
- AP2/ERF domain-containing protein PFD0985w
- Apicoplast ribosomal protein S14p/S29e, putative
- Small ribosomal subunit protein uS5
- RNA-binding protein, putative
- Large ribosomal subunit protein uL24c
Sequence:
MFNNNNEYECLCILEEKLVKHLDVIDKLIENIYDNINNLNEYINKKYNEIKILASKKPTRINWMKCDDKTHMSLFFDKKIGFIPSNEDALKILDSQLMLSNYRKKYEYKKNSWTKKDIDKLFETVDITLKKYACYYLIDQNLSCDEKINKKKMIEQSEPKQIFSQIKLFFDKYNKENTHNKGNEDNVNKNINDNISKNNITHTQNCYEPIEKEQDNSNNIFSYTKNDKNIEHNFLYFSETFWNEVSEKLSNNQNAKECQKMWLYYGCFEDDKQKKWTKDEVDKLLCLSKKYEQRNWKCIARELNTNRSPLSCFEQYIKINKLYENKEKVKLERIAFNVLEDIQLQILVSIIGDKNWAEVKKHMESLNSNTSRIKKRKTNLNFFEKEKQKKFLNDEISYKRRYLRLISATNNMEQ
Protein: Protein sco1 (O42899)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}.
Interaction partners:
- Rsm22-cox11 tandem protein 1
- Rsm22-cox11 tandem protein 2
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase copper chaperone
- Heme A synthase-mitochondrial ferredoxin fusion protein
- Metal homeostasis factor atx1
- Cytochrome c oxidase subunit 3
- Cytochrome oxidase assembly protein shy1
- Copper-transporting ATPase ccc2
- Mitochondrial inner membrane protein oxa1-2
Sequence:
MFRRGLVFSRHCHYSLIRPRFPLNRTCLARFADGRKNLATDNRTQTYQSWRGMISIRALLLAAATSVGLYAYFQHEKKKVLERQNDKVLATIGRPQLGGAFSLIDHHGNRVTDNDFKGKFSLIYFGFTRCPDICPDELDKMSAAIDIVNNVVGDVVYPIFITCDPARDPPQEMAEYLEDFNPKIVGLTGSYEEIKDICKKFRVYFSTPKNIDPKKDDYLVDHSVFFYLMDPEGKFIEVFGRNSTSEDLARAIGSYYLSRKKQK
Protein: Uncharacterized protein YBR197C (P38306)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Maintenance of telomere capping protein 2
- Maintenance of telomere capping protein 4
- Defect at low temperature protein 1
- Uncharacterized protein YBR196C-A
- Spore-specific protein YSW1
Sequence:
MGVKQTPPVQVKVSDADSTNRRKSSSQEGNPQLVQLKAKSDKDKRKGSSDSTASIMGSSNALPTKNLTTPPALNPLTTSISRGNTAYERSVNGSRITMHSNLAPTETQDVSWSEIDTLDDVKKMAKEPIVNDGFPRDFESNLTQMRKSHAQLLRLMRERNQRLKYAKLRSPPHKDQHNSATNKDQEPDEVLHDPEIALDGEKYVSQVVDTIKDVHRC
Protein: CDC45L (Cell division cycle 45) (EG:BACR7A4.11 protein) (LD35753p) (O96989)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA replication licensing factor Mcm6
- Chromosome transmission fidelity 4
- DNA replication licensing factor Mcm7
- DNA replication complex GINS protein SLD5
- DNA replication complex GINS protein PSF1
- Protein MCM10 homolog
- Probable DNA replication complex GINS protein PSF2
- DNA replication complex GINS protein PSF3
- DNA replication licensing factor Mcm5
- DNA replication licensing factor Mcm3
Sequence:
MFVQDLRNDFYRQLVGKRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEHQGDVKYVVLVNCGGCVDIVELLQPSDDVTFFICDSHRPLDVCNIYSDRQVCILGDASLEENIPAFETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERHEQRILKQRARRQWESERDRIMFEYTQFSYYGRSAALMVFELAWKLSKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQIQSHVSRLTNKTNDQNTMSASKITFENDLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEKRLHELLLEMGLPLVHARQTYGAMDLVLRKEFFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAAADYVYALLAIMESVKKHKTPEDCFLEASDALSRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQVHSAGSFFYYVLQEEHAFFSYPYALGLLARFLLRGHVATSRARQASDLPLIASCPLNASEGMCLLVGIVPVREDSPRNFFGKAFEQAAQKSGVALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA
Protein: ADP-ribosylation factor, putative (Q57VI8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 26S proteasome regulatory subunit 4 homolog
- Coatomer subunit gamma
Sequence:
MGALVSQIKSLLGILPADRKIRVLVLGLDNAGKTSILYRLQLGNVTSTVPTVGFNLETLTHKNITFEVWDLGGQANIRPFWRCYFTDTDAVIYVVDSTDKDRMGVAKHELCNLLDEDELRGSLLLIFANKQDVVGAVSEAGVAEQLGVGALSCRTWTIVKSSAKTGEGILEGMDWLCDKLRERGVVTADS
Protein: Signal recognition particle subunit SRP68 (SRP68) (Q9FH46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR038995}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Signal recognition particle 9 kDa protein
- Signal recognition particle 14 kDa protein
- Signal recognition particle 19 kDa protein
- Signal recognition particle subunit SRP72
- Signal recognition particle subunit SRP72
- Signal recognition particle subunit SRP54 3
- Signal recognition particle subunit SRP54, chloroplastic
- Signal recognition particle subunit SRP54 2
- Signal recognition particle subunit SRP54 1
- Cystatin/monellin superfamily protein
Sequence:
MGKKQSEISAMEIDDPKSESSDQILPRFSINVLQLMKSSQAQHGLRHGDYARYRRYCSARLRRLYKSLKFTHGRGKYTRRAILESTVTDVRFLHVVFYMAERAWSHAMEKRQLPDGPNARQRIYLVGRLRKAVKWASLFSSLCSIKTDSRTSLEAEAYASYMKGTLLFEQDQNWETGLACFKNARAVYEELGKYGDLENQVLCRERVEELEPSIRYCLHKIGKSNLQTSELLQIGEMEGPALDLFKAKIEAAMEEARSQQAASLTEFSWLGYRFPVSNPKSRVSILKAQELEKELQSPTAESLPAEKKLTIFDKLFTAYHDARNTIRSDLVSAGNAESVKDDLNGLDKAVGAVLGQRTIERNQLLVKVAKSKLNRKRDDKNDKVTRPEELVRLYDLLLQNVADLSDLISSGRDRKPEEIAFEEECQRTSLAFRAERCFYLAKSYSLAGKRAEAFALYSRARSLAEDALNKFQSIAKKDEGTIQELKTLIKECRANSCIEHATGIMEEERAPENLSNRMSTISLNNTAAQVEEKYLLDKLDVYESAVGDSNTKTAPKIERFPPALQSIPRNPIVLDLAYNCIDFPVIENRMKKKGGFFSSRISSLW
Protein: Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic (Chloroplastic RNA splicing factor 1) (Protein CHLOROPLAST RNA SPLICING 1) (Q9LF10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the splicing of group IIA introns in chloroplasts, by regulating the intron folding. Forms splicing particles with RNA. May also be involved in chloroplast protein translation.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305}.
Interaction partners:
- CRS2-associated factor 2, chloroplastic
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- Transcription termination factor MTERF4, chloroplastic
- RNA-binding CRS1 / YhbY
- Protein WHAT'S THIS FACTOR 1 homolog
- At2g04280
- At4g39040
- Single-stranded DNA-binding protein WHY1, chloroplastic
- ATP synthase subunit b, chloroplastic
- Protein THYLAKOID ASSEMBLY 8, chloroplastic
Sequence:
MRNGINILSYPRFLSFCEVFVLLLCNFSDNPKLQTFTQMLNSLFLSARAFPSLITNSSSRRAKSSQFDQFRENRGVSDAAIKVPTAPWMKGPLLLRPDEILDTKKRNKPRKVEEKTFKALNRRESGVRGKKAMKKIVRNVEKLDEDSDSEETQMDDLSEFEYLGRIEEKVESKDRFGGKMPWEREEERFILRRMKKESVPTTAELILDEGLLNRLRREASKMRKWVNVRKAGVTELVVNKIKSMWKLNELAMVRFDVPLCRNMERAQEIIEMKTGGLVVLSKKEFLVVYRGGPSYSSEGQDEISSSLYEREADRLLDGLGPRYMDWWMRRPFPVDADLLPEVVNGYMTPSRRCPPNTRAKLTDEELTYLRNIAQPLPFHFVLGRNYGLQGLASAIVKLWEKCIIAKIAIKWGALNTNNEEMADELRYLTGGVLILRNKYLIVLYRGKDFLSDEVADLVEDRERLLSRYQHFEETKRESDIELLEVVTNGKQLKETNKSGTLLEFQELQRKFGEMDPRNLETEAEKARLEKELKSQEHKLSILKSKIEKSNMELFKLNSLWKPSEGDDDIEILTNEERECLRRIGLKMNSSLVLGRRGVFFGVMEGLHQHWKHREVAKVITMQKLFSRVVYTAKALETESNGVLISIEKLKEGHAILIYRGKNYKRPSSKLMAQNLLTKRKALQRSVVMQRLGSLKFFAYQRERAIEDLKVSLVNLQDSAF
Protein: Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (TOAD-64/Ulip/CRMP) (TUC-4b) (Q62952)
Organism: Rattus norvegicus (Rat)
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19343716}. Cell projection, growth cone {ECO:0000269|PubMed:12684468}. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000269|PubMed:12684468}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Espin
- Dihydropyrimidinase-related protein 2
- Dihydropyrimidinase-related protein 1
- Semaphorin-3A
- Dihydroorotate dehydrogenase
- Dihydropyrimidine dehydrogenase [NADP
- Mitogen-activated protein kinase kinase kinase 1
- Actin, cytoplasmic 2
Sequence:
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVMPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDAVKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS
Protein: Probable purine permease 8 (AtPUP8) (Q0WRB9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEITQVIYVNDHNNIEANLTGQEEMNTTMEIESSSVPQSKNYKKWLRISIYVFFVLACQALSTILGRVYYENGGKSTWMGTLVQLIGFPVLFLFRFFSQTKNPKPTEADFRKFSSFTILGSVYIVTGLLVSANSYMSSVGLLYLPVSTFSLILASQLAFTAFFSYFLNSQKFTPFIVNSLFLLTISSALLVVNTDSENTAKVSRVKYVIGIICTIGASAGIGLLLSLVQLILRKVLKKQTFSTVTDLVAYQSLVASCVVLIGLFASGEWKTLTSEMENYKLGKVPYVMTLASIAISWQVYTIGVVGLIFESSSVFSNSITAVGLPIVPVVAVIVFHDKMNASKIFSIILAIWGFISFVYQHYLDEKKLKTSHTSPVGDPHLLPAEEGHTNIHSV
Protein: Pericentriolar material 1 protein (PCM-1) (xPCM-1) (Q9PVV4)
Organism: Xenopus laevis (African clawed frog)
Function: Required to anchor microtubules to the centrosome (By similarity). Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including cetn3 and pcnt. Probably involved in the biogenesis of cilia (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8AV28}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q15154}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q15154}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q15154}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q15154}. Note=Recruitment to the centrosome may require cytoplasmic dynein. The majority of the protein dissociates from the centrosome during metaphase. Also associates with microtubules.
Interaction partners:
Sequence:
MATGGGPPDEALSDQDLPNWSHESLDDRLNNMHWNGQKKGNRSAEKNKKKFVECDLRLTNDISPESSPGVGRRRARTPHTFPHTRYVSQMSVPEQAELEKLKQKINFSDLDQRSIGSDSQGRATAANNKRQLADNRKPFNFLPSQLNTNKEKSKSPPKREASTRSLTKDFLASALNKDFLSNSQAFLEEESKREPAIDSSQVVSRLVQIRDYITKASSLRDDLVQKKDLSVNVERLSNLIEHLKFQEKSYLKFLQKMLASENEEEDVRTVDSAVGSGSVVESTLLTFDVPSEASDTTGVDPRQEAKEELKNMKKQHALLTRMLQQQEQLRTLKGRQAALLALQHKAEQAIAKMDESVVTETTGSVSGLSLTSELNEELNDLIQRFHNQLHDSEDPPAPDNRRQAESLSLAREVYRSRNSSTSDTPLEDKSPLFNNVGVLLEKKQKMDTLLGELHTLQDQQLNNTAFVASSVSPRRSTEQRTLGSAVSSALTSDNRAARSPVTIGAYQTASVNESEDEENQNPAEKLKKLKEVRKRLNELRELVHYYEQTSDMMTDAMNENTKDEDETEDSEYDSEQEDAEPTTNIRNPQYRSSWAQMNINSNNQSGTNNRDERQLNTECEINNRSAVNLRSFNMPSALDCLYNIEHSDKEEDGNRELDDEDAEDQGSRASLSSQNSVADDVQSVDFEQKFNRLVAAKQKLKQLQDLVAMYGDDSESEPVAPERSFSGDQFPPEATTLKQQPNNTRPNVSKAQKDIALKEQAREKFYESKLQQQQRELSQLQEERKKLIEIQEKIQTLRKACPDLQLSTSSAGTNPANRQNRQMTTTTSTPDVNTNGNIVVPAMPDPEDSSSVDNEVWSEIRKHQILREDLRQRRKQLETLMAEHQRRQGNTETTSAASIRSDDSDTQGLQQQTRTEKTMATWGGSTQCALEEEEEEEEVDDEECLSDVHQIDIEEDEQDNTSCENNSYPQNSIRKTSFNGRSSKDGWKNQCPLSVEGNHRPSPKTRQQQNVSMRRQENYRWMSELSHVEEKEHWQEQIDQIKKQLDYSTSICQTLMRDQQALSYLLQSMITTPYSVMPSNVGASQVQLIMHQLNQCYTQLNWQQSNVLRLKQMLNDLLVQQPQHLQGESHQREDRGSSAPPLTSPNIFPNFSFLPPTMNLLNMPAFGSIPNVVPGMNFNPVFPHGFENFTQNVASHTDTPLQPHDQNTSGKTEYMAFPKPFESHRSNSTEKERNPPKKPDESEQGRRVWVENHQKSDQEKKPACFGAGLSAGGASAKLAEESRKVKQFDEVSVESLSSMPDPVDPTTVTKMFKSRKASAQASLASKDKTPKAKNKKRKVFHQKSKGIKSCGFQAASASSASEPNQTTCKHAQTEEVVVGNVIKTSSAQRVEKESKATEMSSEAGSDVSMFETLRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQKALFALQDIVTRHVSEGNAKKHETCTKALESTGWMASTSELTPSESLVTTDDEMYAKNSDGPVCQEGEQNDGDNISSLSTSSNFEPFATDDLGNTVIHFDQALARMREYERMKSETENGLVADCCNNLNAAASSLEGTNDEARGRAQHSVDDASGIPCPYIDSKQLDRQIKAIMKEVIPFLKEHMEEVCSPNLLTSIRRLVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFSSKKLKDCGEDLLVEISEVLFNELAFFRLMQDLDNNSTAVQGTVSRKPEAVVVLESFTKEADKEEKTCPEENFSATRETDDEDKDKDETETAEENRNFDAEVLSGKSDISEEDDLDESLPVSISFTKAETQALTNYGSGEDENEDEENYEFEARPVDVQTSLETSSEIADETEKEEMEVRPEANIENEKALSLAVNVMGELSIHEDQAKSDCDVLAHPSLLLSNEKATDFSGTALVNNVKSPVDSPGTSGAGSSDTESPVLVNDFETGSGNLSQKSDEDDFVKVEDLPLKLSLPQEQIMKDIEEEENKNNLCDEILNINDEENGADQLAGDPLALKEPDSPAIHPA
Protein: Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4a) (p16) (p16-INK4) (Q9R0Z3)
Organism: Rattus norvegicus (Rat)
Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESSADRLARAAALGREHEVRALLEAGASPNAPNTFGRTPIQVMMMGNVKVAALLLSYGADSNCEDPTTLSRPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVRYLRYLLSSAGNVSRVTDRHNFCSSTPRCLGLRGQPPKQR
Protein: Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6) (Q0VG99)
Organism: Homo sapiens (Human)
Function: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- T-box transcription factor TBX6
- Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
- Delta-like protein 3
- Transcription factor 4
- Transcription factor E2-alpha
- Protein ripply2
- Transcription factor 12
- Delta-like protein 1
Sequence:
MAQSPPPQSLLGHDHWIFAQGWGWAGHWDSTSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQSASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQCRRRQRGDAGSPWGCPLCPDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQGQGQGRRPGLVSAVLAEASWGSPSACPGAQAAPERLGRGVHDTDPWATPPYCPKIQSPPYSSQGTTSDASLWTPPQGCPWTQSSPEPRNPPVPWTAAPATLELAAVYQGLSVSPEPCLSLGAPSLLPHPSCQRLQPQTPGRCWSHSAEVVPNSEDQGPGAAFQLSEASPPQSSGLRFSGCPELWQEDLEGARLGIFY
Protein: Origin recognition complex subunit 5 (O43114)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.
Subcellular location: Nucleus.
Interaction partners:
- Cell division control protein 18
- Origin recognition complex subunit 3
- DNA replication licensing factor mcm5
- Origin recognition complex subunit 2
- Cell division cycle protein cdt1
- Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- Origin recognition complex subunit 4
- DNA replication licensing factor mcm6
- DNA replication licensing factor mcm3
Sequence:
MHLYQLEDELKKNVFCREDQIKKLSCLLFNKDCRVPSIVLYGVASTAKTFLLRTAFDLSKEENVWINLQDCFTVAHFWYRILIKVGVDKDIALKKGINISGFIYLLEQAMSKRDYHTFLVLDQIDDFAEASTILFSQLAQLPIVANIPNLSIIFVLHSHPAQYLGTLSIAVIFFPQYTQAEILEICQKTPPNLDFLDRSGDSVFEDEIELSVWMQYCSFLWSVFGVQCLNDYRSFRSVLDRYWPKFIQPIVEGDIHPADYAQLHKLAKNFLVSDATVTKRLHIINPTEIKNLLDSKSINLSLVSKYLLVSAFLASYNPSRLDAQFFSFSKTSKRRGRKRKQIQDEGVLFSKIPRTAGSKGRSAVKISQLTLGPKPFEVERLIAIYYAISSPVEKVLTADVFVQIATLASLKMILSASKGVLRSLDSPRYIVNVSREYVLKIADSLSFPLDSYLAG
Protein: ELAV-like protein (Q9PTK4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPNGYEDPMGDEPSDAKTNLIINYLPQNMSQEELRSLFSSIGEVESAKLIRDKMAGHSLGYGFVNYVNPSDAERAINTLNGLRLQSKTIKVSYARPSSDGIKDANLYISGLPKTMTQKNVEDMFTQYGRIINSRILVDQASGLSRGVAFIRFDKRSEAEEAIKDLNGSKPSGASEPITVKFAANPNQSKNSQLLSQLYHTQSRRFGGPVHHQPQRFRFSPMSVDHSVSSMNVASSSSSGWCIFVYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTSKCKGFGFVTMTNYEEAAMAISSLNGYRLGDKVLQVSFKSSKSHK
Protein: Probable glutathione peroxidase 5 (EC 1.11.1.9) (Q9LYB4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May constitute a glutathione peroxidase-like protective system against oxidative stresses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Glutathione reductase, chloroplastic
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase DHAR2
- Glutathione synthetase, chloroplastic
- L-ascorbate peroxidase 3
- Monodehydroascorbate reductase 3
- Glutathione S-transferase F9
- Glutathione S-transferase F6
- Glutathione S-transferase F7
- Glutathione S-transferase F8, chloroplastic
Sequence:
MGASSSSSVSEKSIHQFTVKDSSGKEVDLSVYQGKVLLVVNVASKCGFTESNYTQLTELYRKYKDQGFVVLAFPCNQFLSQEPGTSEEAHQFACTRFKAEYPVFQKVRVNGQNAAPVYKFLKSKKPSFLGSRIKWNFTKFLVGKDGQVIDRYGTTVSPLSIQKDIEKALAQEL
Protein: DUF349 domain-containing protein (O33236)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTADEPRSDDSSGSAPQPAATPVPRPGPRPGPRPVPRPTSYPVGAHPPSDPHRFGRIDDDGTVWLVSASGERIVGSWQAGDPEAAFAHFGRRFDDLSTEIMLMDERLASGTGDARKIKAHAIALAETLPTACVLGDVDALADRLTSIRDRAEVIAAADRSRREEHRAAQTARKEALAAEAEELAANATQWKVAGDRLRAILDEWKTISGVDRKVDDALWKRYSTARDTFNRRRGSHFAELDRERSGVRQSKERLCERAEELSESTDWTATSAEFRKLLADWKAAGRASKDVDDALWRRFKAAQDSFFTARNAATAEKEAELRANADAKEALLAEAERLDTTNHEAARAALRSIAEKWDAIGKVSRERAAELERRLRAVEKKVREAGEADWSDPQARARAEQFRARAEQFEHQAEKAAAAGRTKEADEAKANAEQWRQWAEAAADALTRRP
Protein: UDP-glycosyltransferase 76C4 (EC 2.4.1.-) (Q9FI98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nicotinate N-methyltransferase 1
- Nicotinate phosphoribosyltransferase 1
- Nicotinate phosphoribosyltransferase 2
- Nicotinamidase 1
- Glutamine-dependent NAD
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Acetylornithine deacetylase
- Organic cation/carnitine transporter 7
Sequence:
MEKSNGLRVILFPLPLQGCINPMIQLAKILHSRGFSITVIHTCFNAPKASSHPLFTFIQIQDGLSETETRTRDVKLLITLLNQNCESPVRECLRKLLQSAKEEKQRISCLINDSGWIFTQHLAKSLNLMRLAFNTYKISFFRSHFVLPQLRREMFLPLQDSEQDDPVEKFPPLRKKDLLRILEADSVQGDSYSDMILEKTKASSGLIFMSCEELDQDSLSQSREDFKVPIFAIGPSHSHFPASSSSLFTPDETCIPWLDRQEDKSVIYVSIGSLVTINETELMEIAWGLSNSDQPFLWVVRVGSVNGTEWIEAIPEYFIKRLNEKGKIVKWAPQQEVLKHRAIGGFLTHNGWNSTVESVCEGVPMICLPFRWDQLLNARFVSDVWMVGIHLEGRIERDEIERAIRRLLLETEGEAIRERIQLLKEKVGRSVKQNGSAYQSLQNLINYISSF
Protein: Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin) (Q811S9)
Organism: Rattus norvegicus (Rat)
Function: May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:15657390}. Nucleus, nucleolus {ECO:0000269|PubMed:12464630, ECO:0000269|PubMed:15657390}. Note=Shuttles between the nucleus and nucleolus (PubMed:15657390). {ECO:0000269|PubMed:15657390}.
Interaction partners:
- Pescadillo homolog
- Nucleolar GTP-binding protein 2
- Ribosome biogenesis protein BOP1
- GTP-binding protein 4
- EBNA1 binding protein 2
- Ribosome biogenesis protein WDR12
- Ribosome assembly factor mrt4
- Ribosome production factor 2 homolog
- NOC2-like nucleolar associated transcriptional repressor
- MKI67 FHA domain-interacting nucleolar phosphoprotein
Sequence:
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPKKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEISPDDEQSNVETQEESDEPKIKKAKSGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQVEEAVIQSGCKKLVLVLNKSDLVPKENLENWLTYLNKELPTVVFKASTNLKNRKKTFKIKKKVVPFQSKLCCGKEALWKLLGGFQQSCGKGVQVGVVGFPNVGKSSIINSLKQERICSVGVSMGLTRSMQIVPLDKQITIIDSPCFIISPCNSPAALALRSPASIEVLRPLEAASAILSQADSQQVVLKYTVPGYKDSLDFFTKLAQRRGLHQKGGSPNVESAAKLLWSEWTGASLGYYCHPPASWNHSPHFNENITAIMKRGFNLEELEKNNAHSIQVLKGPHLTNKILFRSSGLTNGILEEKDIPEESPKQTEDQQDGDDQEHVTGEKNAEISDVTPVEETREMSPGQSTASKPSDRSFILDKMSEEDDAYDFTTDYI
Protein: Major facilitator superfamily domain-containing protein YCR023C (Chloride channel protein YCR023C) (P25351)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:34910516}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein YCR025C
- Asparagine--tRNA ligase, mitochondrial
Sequence:
MARQKLTFKEQMDGFPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDGTMNEVPLWFPHFAKRIIRSYPYALPNVVVCMFLMFGLTNATLFLEETHPAFKDRRDYGLEVGDFIKKNIFGIQPKRRPWQKRIQDDSENIHHRNENVNSIRGQDSEEDENSPLVNTTNDDDTESIQSIDPILTRRQSVGLIRTYSLHEPTDAVHANIDTAPDGCKESSIFHHVFHTKVFYPISVNFIMALHLIVYNEFLPVFLAYDLAVDPENPKKLASKFPWKISGGIGYEPEQTGTLLSTTGIFGCFVVIFIFPIVDRNFDCLTIFRTLVKLYPIMYVMVPYVVFLQNERIPSWYTVVYLYIITGIKTFCGALTSPQIMLLIHNSSPLSCRSVINGATISISASARFIGPLVWGYIMSWSQQNDVAWVSWWSLSLFCMVALYQSYKIAPIDDNENELHGQGSEDAYNSQSQSSDLRMAHRSSLSSLSNQRCTT