wanglab/gogpt-training-data huggingface dataset:
Protein: Transmembrane protein 132A (GRP78-binding protein) (HSPA5-binding protein 1) (Q80WF4)
Organism: Rattus norvegicus (Rat)
Function: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12514190}; Single-pass type I membrane protein {ECO:0000269|PubMed:12514190}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12514190}; Single-pass type I membrane protein {ECO:0000269|PubMed:12514190}.
Interaction partners:
- Transmembrane p24 trafficking protein 6
Sequence:
MTERAAAAPRGPYGAWLCLLVALALEVVRVGSNQNTLDPIYLPVALELLDAPEHFRVQQVGHYPPANSSLGSRSETFLLMQPWPRAQPLLRASYPPFATQQVVPPRVTEPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHATHPAGTAHQACRFQPSLGACVVELQFPSQWFSQSATTRAELAYTLEPAGEGPGGCGPGTEEEPKEQALPVGSVELHPEDPPQHQEVPLDEVVTLRAPDVPVRPGQLFTATLLLRHNFTASLLTLRIKVKKGLQVTAARPAQPTFWTAKLDRFKGSKHHTSLITCHRTGPAGPDSRPLELPEFLWVDFAVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILFSERDIRALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVAGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGPAEGQLEPEAAAEEVERRSRGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAAHAHVQDPRIATLEGGRILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLDLRVQPVMGISLSLSRGVSHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSVSAEEPSAVVPAEEQRAQLGVVVSGVGAKGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPLPTPAPALPSSPARTPPFTEASVEGKRQVAGDMGSHVGPGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCLAFLIFLVNGVVFVLRYQRKEPPDSVTDPASPQPHNWVWLGTNQEELSRQLDRCSSSSPPKGEGGCPCESGAGGDTSTVAPSASESPAGSTSTLARKEAGGRRKRVEFVTFAPAPPAQEAPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS
Protein: Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) (P52333)
Organism: Homo sapiens (Human)
Function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Interleukin-2
- Cytokine receptor common subunit gamma
- Tyrosine-protein kinase JAK1
- Signal transducer and activator of transcription 5A
- Interleukin-4
- Signal transducer and activator of transcription 3
- Interleukin-7
- Signal transducer and activator of transcription 5B
- Interleukin-9
- Interleukin-15
Sequence:
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Protein: Tripartite motif containing 11 (R4GMV1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSHGPAWPLPQAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
Protein: Uncharacterized protein, isoform F (A0A0B4LHR2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRGLVEDTKRTKLSSANNNNLSSTSGSGRIKSSSLATGSSASGSSSKPLRSAVKTPTSGSATSLSSGTMAAKKAPQTGQQQVGKSAKSATAATPTGTTATAIGATATTRAQAAAAKSQKGQNPPSQQVQPKQQPPQPQQTQQQPLVLQQQQASNSSNTIALPKASHANTSEELAGGVQDTIYLCNFRVSVDGEWLCLKELQDIDVAGGTGNQAAQTSEKLAGGSSSQTGGFGSNYNVGSSSSKRNSKRFSGLSTGSGSGGNAGGGGGLDITDNARDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQECEDELTQKGEMVSRLQTKASQIGNILQSLEKKYESKLIDQQHHGPGSGSGTGAGTGAGNGAIGGDRSPNTRRQQNLEKFEALTKKHKQDAGPPMKRMHLKMDAFPPFDPSKYRKSPRQPDAPNTEELQQSKDAKTPTSAKSLNDELAEAAAAVTQHFGVDASQSDYVLCREQAADGET
Protein: CSC1-like protein 2 (Transmembrane protein 63B) (Q5T3F8)
Organism: Homo sapiens (Human)
Function: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity).
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:38127458}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with cortical F-actin (By similarity). Localizes at lamellar body membrane in alveolar type 2 cells (By similarity). {ECO:0000250|UniProtKB:Q3TWI9}.
Interaction partners:
Sequence:
MLPFLLATLGTTALNNSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRPSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSEVDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ
Protein: Tumorous testis (Q8IQA2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Meiotic P26, isoform F
- Protein bag of marbles
Sequence:
MDFESKYCTSQVNGTITITTRKVLDENLKSLLDEGKGELFLSCIPRNHSCSPRWIVEVASELGEVYIMRYKIDFSGNSRGYAYLQYINVDLKESAMQYLPMRFRQLCMCLRVEPSTNNRELVLKNVESSLRPWQVYQEMLKIHPFTIVRVYEYQLDQFFYIFEYRNNDSAASAHQRVRNSIRKFGEHAHISWLTAENILSRASGSFCFQREVSQNRTRRVPPRQKGCFKF
Protein: Small regulatory polypeptide of amino acid response (A0A1B0GSZ0)
Organism: Mus musculus (Mouse)
Function: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (By similarity). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (By similarity). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation.
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:A0A1B0GVQ0}; Single-pass membrane protein {ECO:0000250|UniProtKB:A0A1B0GVQ0}. Lysosome membrane {ECO:0000250|UniProtKB:A0A1B0GVQ0}; Single-pass membrane protein {ECO:0000250|UniProtKB:A0A1B0GVQ0}.
Interaction partners:
- V-type proton ATPase subunit d 2
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit H
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit F
- Vacuolar ATPase assembly protein VMA22
- V-type proton ATPase subunit e 2
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit G 1
- Vacuolar ATPase assembly protein VMA12
Sequence:
METAVIGMVAVLFVITMAITCILCYFSYDSHTQDPERSSRRSFTVATFHQEASLFTGPALQSRPLPRPQNFWTVV
Protein: Propionyl-CoA carboxylase beta chain (EC 6.4.1.3) (Q168G2)
Organism: Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Function: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (Probable).
Interaction partners:
- propionyl-CoA carboxylase
- Methylcrotonyl-CoA carboxylase, alpha subunit
- methylmalonyl-CoA epimerase
- Biotin carboxylase
- Acetyl-coenzyme A synthetase
- Acetyl-coenzyme A synthetase
- Propionate--CoA ligase
- methylmalonate-semialdehyde dehydrogenase
- Fatty acid oxidation complex alpha subunit, putative
- Malyl-CoA lyase
Sequence:
MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCTDFNMQDQKPAGDGVVTGWGTINGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGAPVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQISMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRRLVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQEEFAKNIITGFIRLEGRTVGVVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLIDVPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRKAYGGAYVVMSSKHLRADFNYAWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPRSTRKRVARAFASLRNKSVQMPWKKHDNIPL
Protein: Heat shock protein 70 (Heat shock protein Hsp70) (Q7SX63)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MSGKGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKYDDPTVQSDMKHWPFRVVNEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYLGKKVQNAVITVPAYFNDSQRQATKDAGTITGLNVMRIINEPTAAAIAYGLDKKGTRAGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFVEEFKRKHKRDIAGNKRAVRRLRTACERAKRTLSSSTQASIEIDSLFEGIDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVTPLSLGIETAGGVMTALIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKDDIDRMVQEAEKYKAEDEANRDRVGAKNSLESYTYNMKQTVEDEKLKGKISDQDKQKVLDKCQEVISWLDRNQMAEKEEYEHKQKELEKLCNPIVTKLYQGAGGAGAGGSGGPTIEEVD
Protein: Calcium-regulated OB-fold protein CarO (Bacterial OB-fold domain-containing protein) (Q9I6H1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Periplasm {ECO:0000303|PubMed:26755627}.
Interaction partners:
- Calcium-regulated beta-propeller protein CarP
- Response regulator protein CarR
- Sensor protein kinase CarS
- PepSY domain-containing protein
- Probable transglycolase
Sequence:
MKLRHLPLIAAIGLFSTVTLAAGYTGPGATPTTTTVKAALEAADDTPVVLQGTIVKRIKGDIYEFRDATGSMKVEIDDEDFPPMEINDKTRVKLTGEVDRDLVGREIDVEFVEVIK
Protein: Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-conjugating enzyme E2-21 kDa 1) (Ubiquitin-protein ligase 4) (P42748)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 5
- Ubiquitin-conjugating enzyme E2 6
- Ubiquitin-activating enzyme E1 1
- Ubiquitin-activating enzyme E1 2
- NEDD8-activating enzyme E1 catalytic subunit
- RING-H2 finger protein ATL63
- Ubiquitin-like modifier-activating enzyme atg7
- Peroxisome biogenesis protein 5
- Peroxisome biogenesis factor 10
- Ubiquitin-conjugating enzyme E2 27
Sequence:
MSSPSKRREMDMMKLMMSDYKVETINDGMQEFYVEFNGPKDSLYQGGVWKIRVELPDAYPYKSPSVGFITKIYHPNVDELSGSVCLDVINQTWSPMFDLVNVFETFLPQLLLYPNPSDPLNGEAAALMMRDRPAYEQRVKEYCEKYAKPGEGSEDKSSDEELSEEEYGSDNEDDDDDDVAIAGKPDP
Protein: Lycopene beta-cyclase (EC 5.5.1.19) (B0R753)
Organism: Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Function: Catalyzes the cyclization of both ends of lycopene to form beta-carotene, a retinal precursor. Is required for bacteriorhodopsin biogenesis, a light-driven proton pump with a covalently bound retinal cofactor.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MTTSYLTFLAVAVGPPLVALGVVRAARWDGDRARAAGVGILLALALSYTTPWDNYLIATGVWWYGEGTVVGRLWQMPIEEYLFVITQTLLTGLWVQALPLRPTAGFSPTRRDAVLGALAGVLVGCGGAVLLTVDATFYIGAIIAWAAPVLALQWAVGWRYLWRRRRVFAAAVLVPTLFLSAADRYAIADGIWILAGQYTTGITVLGLPIEEGAFFFVTNVFVSQGLILYAWVLARWR
Protein: GLIPR1-like protein 2 (Q4G1C9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
Sequence:
MEAARPFAREWRAQSLPLAVGGVLKLRLCELWLLLLGSSLNARFLPDEEDVDFINEYVNLHNELRGDVIPRGSNLRFMTWDVALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCAVTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRILCFILCVITVLIVQSQFPNILLEQQMIFTPEESEAGNEEEEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEETQKEKMEEEEK
Protein: Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (Q7TPS0)
Organism: Mus musculus (Mouse)
Function: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic. {ECO:0000250}.
Interaction partners:
- Mitogen-activated protein kinase 7
- Mitogen-activated protein kinase 3
- GTPase KRas
- GTPase HRas
- Mitogen-activated protein kinase 1
- Tuberin
- Hamartin
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- GTPase NRas
Sequence:
MLPFAPVEDPWDQEDMEVFGSTSSSEPQVVFTMKNAATVMREHERKEVNDLKMVDEPMEEGEPVSCRREELVKEVPITQHVKEGYEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRAHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEVKRHAFFASIDWNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPVTSSNVLPIVQINGNAAQFSEAYELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPSEEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQVLKHPWITQREQLPRHQPNSDEPPQEAVAAPYSVLARNPNRHHPILEPVTASRLAQRRNMKKRTSTGL
Protein: Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) (Q9GZM7)
Organism: Homo sapiens (Human)
Function: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:10799322, ECO:0000269|PubMed:11170462}.
Interaction partners:
- Basement membrane-specific heparan sulfate proteoglycan core protein
Sequence:
MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
Protein: ABC transporter PGP-2 (p-GlycoProtein related) (G5EDF9)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGKDTEKTPLLLKSLDKQRSQTSLSSHSSDSSIDESTVKLTNYGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPEGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVEECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLPADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRYVFTRLPVVLASIVTICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQRIVESQ
Protein: Cripto, FRL-1, cryptic family 1 (A0A8I6GC89)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRGNSATQGVGLKTNGARPLFLMTVALQLIRPGNSYQREGDGAREISYLLSPKLPGTTLDGTLSSSSRKNDSQEGAHPSEALSGSNTLEESAVPGSRCCHNGGTCVLGSFCVCPAHFTGRYCEHDQRHRDCGALGHGAWTLHSCRLCRCIFSALYCLPRQTFSHCDLKSFLSSGARGSRACSIPRLLLLVLCLLLQVVCGW
Protein: T48 protein (Q24548)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRSVEVAQSGPSAIFWLVQVLIVGAAQAATPFAKEYRNAGLYNGNTLVDLDGSTTLDMGQEKPTSSSSGLSGGFKSESSVVLPGMLQNSGCPLTTSSHCLRCNKAGCIKCPMYLVTDTRQCVDQCPAGYLDQWSAHTEFMGRVCVPTGYSGPLMAALAGLLGGFLVCLSLLAVAVMLVKRKRRRKSIKQKLINENTMDRADFMRQLNEMRPNAEYFLAMLNDTRRQIRKLYLSGEVAAANSYRPIVRDLAKLLILLNRPIELIPAPPPDWSRLYAWSEQALERYKPQVGQLIDFFQASHGHSAGHHEVLYAAPNKKKQLQQSSIFRQQVTPTATPQGVGELMAGDRSSSASAQQKLHLFGSLISLHEFEEPRASDPFGSSFNTLKSGNLISDLNASSLWLEDEFYKLGFRPQDEITTEL
Protein: Type 4 fimbrial biogenesis protein PilY2 (G3XD55)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Type 4 fimbrial biogenesis protein PilW
- Type 4 fimbrial biogenesis protein PilV
- Type 4 fimbrial biogenesis protein PilX
- Type IV pilus non-core minor pilin PilE
- Type IV pilus biogenesis factor PilY1
- Type II secretion system protein H
- Type II secretion system protein H
Sequence:
MKVLPMLLALAVPGLCWAEDPQTFEGAGVVFEVQVEKNLVDIDHRLYRLPNSTVRNGMPSLFQVKPGSVVSYSGTVSQPWSTITDIYIHKQMSEQELAEMIEKEQPRQDGEEQPR
Protein: Receptor tyrosine kinase-like orphan receptor 1 (A0A8I5ZQX3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MNNITTSLGQTAELHCKVSGNPPPNIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATSGKKVVSTTGVLFVKFGKQPSTGLATDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCHTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFFFICVCRNNQKSPSPPVQRQPKPVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRFPNYMFPSQGIPPQGQIAGFIGPAIPQNQRFIPINGYPIPPGYAAFPAAHYQPAGPPRVIQHCPPPKSRSPSSASGSTSTGHVASLPSSGSNQEANVPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQPSLLGDSNIHGHTESMISAEV
Protein: Probable WRKY transcription factor 53 (WRKY DNA-binding protein 53) (Q9SUP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. May regulate the early events of leaf senescence. Negatively regulates the expression of ESR/ESP. Together with WRKY46 and WRKY70, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223, ECO:0000269|PubMed:17369373}.
Interaction partners:
- High mobility group B protein 6
- Probable serine/threonine-protein kinase PIX13
- CBL-interacting Serine/Threonine-kinase
- E3 ubiquitin-protein ligase UPL5
Sequence:
MEGRDMLSWEQKTLLSELINGFDAAKKLQARLREAPSPSSSFSSPATAVAETNEILVKQIVSSYERSLLLLNWSSSPSVQLIPTPVTVVPVANPGSVPESPASINGSPRSEEFADGGGSSESHHRQDYIFNSKKRKMLPKWSEKVRISPERGLEGPQDDVFSWRKYGQKDILGAKFPRSYYRCTHRSTQNCWATKQVQRSDGDATVFEVTYRGTHTCSQAITRTPPLASPEKRQDTRVKPAITQKPKDILESLKSNLTVRTDGLDDGKDVFSFPDTPPFYNYGTINGEFGHVESSPIFDVVDWFNPTVEIDTTFPAFLHESIYY
Protein: Alpha/beta-Hydrolases superfamily protein (At5g11910) (Q24JN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSETRRNQSSDEQIEKSEIQHQRVVIENSHGEKLVGVLHDTGSTETVVICHGFRSSKNRIPMLTIASFFERAMISSFRFDFAGNGESQGSFQYGNYRREVEDLRSVLQHLRGVNRVISAIIGHSKGGNVVLLYAAKYNDVQTVVNISGRFFLDRGIEFRLGKDYFKRIKDNGFIDVSNRKGKFEYRVTEESLMDRLTTNAHEACLSIRENCRVLTVHGSNDRIVHVTEASEFAKQIKNHKLYVIEGADHEFTSHQHQLASIVLSFFKLDPKKDDESGDISTSNQDSMRSVVPITSRI