wanglab/gogpt-training-data huggingface dataset:
Protein: Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) (Q5ND28)
Organism: Mus musculus (Mouse)
Function: Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein (By similarity). Plays a role in the regulation of neurite-like outgrowth.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Hypoxia up-regulated protein 1
- Calreticulin
- Scavenger receptor class B member 1
- Platelet glycoprotein 4
Sequence:
MLAAMGLELVFSLLLLWTQGTQGSTLDPAGQHVCKGSSPSELQCCPGWRQKDQECTIPICEGPDACRKEEVCVKPGLCRCKPGFFGAQCSSRCPGQYWGHDCRETCPCHPRGQCEPATGDCQCQPNYWGRLCEFPCTCGPHGQCDPKTGLCHCDPGWWSPTCRRPCQCNPASRCDQATGTCVCPPGWWGRRCSFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRGQCSVTSGHCSCPPGFHGIRCELPCNPGHYGAQCKESCGHCELNATCSPVTGNCESCKPGWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQHCDPGWLGHRCENPCPLGTFGKGCSSTCPACAQGTCDAVTGECVCSAGYWGTSCNSSCPAGFHGNNCSMPCQCPEGLCHPVSGTCQLGRHGKNALIVGILVPLLLLLMGIVCCAYCCSGTRLDPKDRPERNGAAFFRMKQQVWGALTNLGSALPCGSLSNYKLPWVTVSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDSGEEDEAHAYFVPPREEMVPMAQEESPEASLPGGSFPPPEDASTPFPIPRTSSLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPEGQEAEESTGPEQVNTEEDAPTATSSGDPATSHGQLPPGSQMVAECAETTDGGIQESSGSVATIYMLAGTPQKPEGPVWSVFRRLGNYQKDQMDPKVKSAIPKPLRRSLGRNQASAGSAPGAVLSQAMESTAVRPEETPRGLGDGIESSGTVQEPDAGGSSLEQDSQKQAEEKEQEEPLYENVVPMSVPPQH
Protein: Potassium voltage-gated channel subfamily Q member 1 (A0A2R8YEQ9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPATAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKSTKKRPSPGS
Protein: SH3 domain-containing protein (Q5ZMQ7)
Organism: Gallus gallus (Chicken)
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Uncharacterized protein.
- B-cell linker protein
- Growth factor receptor-bound protein 2
- DAB1, reelin adaptor protein
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Very low-density lipoprotein receptor
- Reelin
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MAAPAAVPGSRGRPAARNGARPRATDRREQKKARAAGGVHPPTDSCPGVPSESGSRRPPSQKCRWRPESGTAKAVPYHALVEAIVEFDYKAQHDDELTITVGDIITNIKKDDGGWWEGQLKGRRGLFPDNFVREIKKDMKKENIANKPPEKPINEICNGSSLLLSETIIRTNRKGERNRRRRCQVAFSYLPQNEDELELKVGDIIEVVGEVEEGWWEGILNGKTGMFPSNFIKELSDSDDAGIAQEEQVKPSLKDTTGSESDGGDSGSTKSEGANGGTTIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVDKSVGKKVPPATASQESTKTEVDSRTKTKEYCKVIFPYEAQNDDELTIREGDVVTLISKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFEKERPKKPPPPSAPVVKQGLGTTDRKQEVKKVPPERPECLPNRTEEKERSEREQKQLDLQKPSVPAIPPKKPRPPKANPVSRPGTLPPRRPERPVVPATHARSDSPKVELVGSSVSSTLEKDSSDRSNDIDLEGFDSVVPIAEKLNHPTTTRPKATGRRPPSQSFTSSSLSSPDFFDSPSPEEEKDEHVSITHKTIEVSRKSRTVTISQVFDNKTSLPPKPGGLASGSNVQPSLSPSPSPGFHSIAMGTTGHRSNSPSLLGAEGKPKTEQLSQGQTALEELRTQVKELRTIIETMKDQQKKEIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
Protein: E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69) (Q86WT6)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. Plays also a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23131556, ECO:0000269|PubMed:31578292, ECO:0000269|PubMed:36251989}. Nucleus {ECO:0000269|PubMed:23131556}. Nucleus speckle {ECO:0000269|PubMed:23131556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:37739411}. Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules. {ECO:0000269|PubMed:36251989}.
Interaction partners:
- Melanoma-associated antigen 4
- Biogenesis of lysosome-related organelles complex 1 subunit 5
Sequence:
MEVSTNPSSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEKIKKLPLLKGHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ
Protein: Serine/threonine-protein kinase PKH2 (EC 2.7.11.1) (PKB-activating kinase homolog 2) (Q12236)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.
Subcellular location: Nucleus. Cytoplasm, cell cortex. Note=Localizes at eisosomes, large, immobile complexes that mark sites of endocytosis near the plasma membrane.
Interaction partners:
- Serine/threonine-protein kinase PKH1
- Protein kinase C-like 1
- Serine/threonine-protein kinase PKH3
- Sphingolipid long chain base-responsive protein PIL1
- Sphingolipid long chain base-responsive protein LSP1
- [Pyruvate dehydrogenase
- Serine/threonine-protein kinase SCH9
- Serine/threonine-protein kinase YPK1
- Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1
- Serine palmitoyltransferase 1
Sequence:
MYFDKDNSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLLEKRTAKPMIQKALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGKTVASTNDGRYDNDYDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEIKPYKINAKSMQAMPSGSDRKLVKKSVNTLGKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGINNRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDIQWSFYLKNINEHVLRTEKLDFVTTNYDILEKKMLKLNGSLLDPQLFGKPRHTFLSQVARSGGEVTGFRNDPTMTAYSKTEDTYYSKNIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSSVFSGKIKKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRFLVFAKRRQPNPVTNLKYELEYDINLRQQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKTTSKLFTVLKKILNSNTNKIEKELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSNRSSRIFETFINAKEQNSKKHAAPVPLTSKLVNGLPKRQVTVGLGLNTGTNFKNSSAKSKRS
Protein: carboxylesterase (EC 3.1.1.1) (Q24195)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAQFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYMGDEKDADVLSFLSKVSARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVWPKRPKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQXRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYPRESLF
Protein: ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3) (Q9NZC4)
Organism: Homo sapiens (Human)
Function: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029}.
Interaction partners:
Sequence:
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN
Protein: TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1) (Q8TEA7)
Organism: Homo sapiens (Human)
Function: Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23977024, ECO:0000269|PubMed:24576458}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24576458}. Midbody {ECO:0000269|PubMed:24576458}. Early endosome {ECO:0000305|PubMed:37267905}. Note=Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody. {ECO:0000269|PubMed:24576458}.
Interaction partners:
- Ferry endosomal RAB5 effector complex subunit 3
Sequence:
MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
Protein: Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) (Q69YH5)
Organism: Homo sapiens (Human)
Function: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Subcellular location: Nucleus {ECO:0000269|PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Chromosome-associated kinesin KIF4A
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Outer kinetochore KNL1 complex subunit KNL1
- Cell division cycle-associated protein 3
- Kinesin-like protein KIF11
- Kinesin-like protein KIF20A
- Disks large-associated protein 5
- Mitotic checkpoint serine/threonine-protein kinase BUB1
Sequence:
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ
Protein: At5g11600 (Q9LYD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MATQERPSSAKSEPRDASSSLSSRVKIDPSIKDKKKIATSSRPIMSDSKPRSSVSTVTAKSEAKPKVPINSVKTIATTSAAASLVKGKAQTTSTVVSLVKAKTTSATVSLVKGKAKREKKVYSLAGQKFDPPEEREPLRIFYESLSKQIPGSEMAEFWLMEHGMLSPEKAKRAFEKKQRKMKQIRMGTPSKSAPTFSSKAESSQRTSASKNNGLDARKKKKVVDDDDDDDDDFILSHKRRKV
Protein: Pleckstrin homology domain containing A7 (A0A8I6GKY3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAAVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASFFIDHNQQTTTFRHPVTGQFSSENSEYVLREEPHPHMSKQERNQRPSSMVSETSTAGTTSTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQAEHSGMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLKRDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDAIVFDRREQEEERFRSQRDTLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAERNGLPPYGLGEQNGTSGYSRTAPPRANLEKHSQRKTNLAQTEHWAKAQKGDGRSLPLDQTLPRQGPSQPPSFLENYQTLPRNTRYPSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKPPDQRRSVDISLGGSPRKARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPMKIAESDTDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSVNKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVVSPLQSPTKATPQAEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASFSGDVPRPSLGLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSVTFSRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLLSARYLSQPLPGDLGSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELDLEPQDYDLDINRELSKPEKVSIPERYVEVDPEEPPSVEELQARYQKAEKIRNILARSSMCNLQPPGQDRNSLADLDTQMQEQERIINISYALASEASQRSKQVAAQAVTDP
Protein: Proton channel OTOP1 (Otopetrin-1) (Q80VM9)
Organism: Mus musculus (Mouse)
Function: Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29371428}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7ZWK8}. Cell projection, microvillus {ECO:0000269|PubMed:20554841}. Note=Found in the gelatinous membrane overlying the inner ear macular epithelium (PubMed:12651873, PubMed:21236346). Also detected in the apical microvilli in inner ear supporting cells (PubMed:20554841). {ECO:0000269|PubMed:12651873, ECO:0000269|PubMed:20554841, ECO:0000269|PubMed:21236346}.
Interaction partners:
- Otoconin-90
- Transmembrane protein 128
Sequence:
MPGGPGAPSSPAASSGSSRAAPSGIAACPLSPPPLARGSPQASGPRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVGRSYMQRRLIRPKDTHAGARWLRGSITLFAFITVVLGCLKVAYFIGFSECLSATEGVFPVTHAVHTLLQVYFLWGHAKDIIMSFKTLERFGVIHSVFTNLLLWANSVLNESKHQLNEHKERLITLGFGNITIVLDDHTPQCNCTPPALCSALSHGIYYLYPFNIEYQILASTMLYVLWKNIGRRVDSSQHQKMQCRFDGVLVGSVLGLTVLAATIAVVVVYMIHIGRSKSKSESALIMFYLYAITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDVDLLVATGSGSWLLSWGSILAIACAETRPPYTWYNLPYSVLVIVEKYVQNIFIIESVHLEPEGVPEDVRTLRVVTVCSSEAAALAASTLGSQGMAQDGSPAVNGNLCLQQRCGKEDQESGWEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAAALFEVYCKI
Protein: Uncharacterized protein, isoform B (M9PHF9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAIDDMKDLLIVNVSDQEDADDLKETAMDCNMPDGESSLVITDGDSMSKIPDDAAMATSDPKKKKKKVKKLKRSQKAKDRLVRPLPKAVTSKDALMVLKELKGVIIDNMQIKQDHEGKNVANIVVNSKKYDAEGSSENSAGNAACEKALREILTTKMKALLAEPENSSGGDEDNILEKMTSYAVYKLAEKWNSDAIDVAALYNDVKNKKTSSSVGQLPKLWKNMHPCMVLMQMRPQTTFKFLGSSGENRKVFSMGVSVDNCEFKADGPTKKDARRKVAALVCNKLFGTDYPQA
Protein: Rhomboid domain-containing protein 3 (Q8BP97)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Rhomboid domain-containing protein 2
Sequence:
MHAWEAPGSLSRALPLASSVLMLLLSCLWLLGAGPSLRLAPELLMEPWQVHRLLTHALGHTALPGLLLSLLLLPTLGWWQECHLGTVRFLHNSTVLALATGLLAVLLAGLGVSGAAGGCGYMPVHLAMLAGQSHHPGWPQRTLPPWLLPWLLLALTLLLSSEPPFLQLLCGLLTGLAYAAGAFQWLELSEQRLQVLQEGVLCKSLARCWPLRLFPTPGSLGELPVTYPAGVRPATPRPPYLASSDSWPHSDGSAQLPPRLGPGQLTWKNSERGLDWAGSSFASATTMWAALDEQMLQEGIQASLLDVSVQGSQSSLWLPKPSVSSLRLQQLQHMGFPTEQAAVALAATGRVEGAVSLLVEGLVDTEALVTEGRSSPAHCTGTGAS
Protein: GATA zinc finger domain containing 2A (C9JJK9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTEEACRTRSQKRALERDPTEDDVESKKIKMERGLLASDLNTDGDMRVTPEPGAGPTQGLLRATEATAMAMGRGEGLVGDGPVDMRTSHSDMKSERRPPSPDVIVLSDNEQPSSPRVNGLTTVALKETSTEALMKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATAQ
Protein: Flagellar attachment zone protein 1 (Q585H6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:17945531}. Note=The flagellum attachment zone (FAZ) is a complex structure comprising a FAZ filament structure, a specialised microtubule quartet (MtQ) and the plasma membrane attachment, a specialised area of flagellum. {ECO:0000269|PubMed:17945531}.
Interaction partners:
- Calpain, putative
- Clu domain-containing protein
- Serine/threonine-protein kinase PLK
- Kinesin, putative
- MSP domain-containing protein
- Nucleoside diphosphate kinase-like domain-containing protein
Sequence:
MALLNVISENPLTLQPGQVIAFDHLANGEHWQWALGTVVSSDKHVVVVEQWAVNEGSCETLKHNISSEIQKEMKRMGVFQEQLSSARDKLAAIRSENEDRVSAARAVFEDAKARVASVDEVHMREVTSQACPSPVAVEVLKSVLALAQNDPTVTNCSTWDDIRMEYRRPNAIADFISADITGKTYPNAEEICSSLNEQRLSSLAASRDSEAISSLHHWVLSALAYQEAYCRLTTDTRVQEQNDAIANCIAGMKGCRLKVMKLKEELERGGTPTFGGQLTSFTKTSVQLKAPLSSVISIVGVDPSAQDCVLTDDEVGLILDKAEQTRLQINDHFSHLSNSYMEAMAELHCLSMYTSELEERRLNLQERFVFSLFTNAGKTNAPRRERIETDVGLRSVEAPRGDSANNIKDLQEIIKELSSHDERWMYRNEPTVTTKHRKSYPGREWSKVVERKPEELLSTFRTEQAAACHVPEDAIRNIEFTATSEKLQVSFDVQHPVKQTAAEINKRLQEFPSRGMDRMLCDVDQPKKGLDRAIVEVCRAFDLREHAFRGMTFDKFIEEVAMKGRVGDKDAYESEIGDLLMLLDKIHNENRSLQYTLEKSAEEFRRQTASTMREQESLRQRNGELHAEIGRLRDLVEKLRDLADNQASELELLKLQKTQANQIRAQRNLSTFRGDDTAEPVYCVTLDELREQTEHCDQVERELERQREQCQNLLNAQDDLLAELSGVSEEKEKLEAECERLEAELRQMEEKSRLSEQGLSEMTQRLEEKQAEIEGLLENLEQLDEQLEALRAAEKSAQAHIEARDREISDLQQRLEGEIDDHIKTTALLEELRKHYNNLEELFDKQEAELMAYREKRQNAHKVRSLEPTLRPIGTQTKPFQEMVSADEISSEPLLSVTLDEYNDHMHRSNQFQQENDLLRQQLQQANDERENLHDRLEQLMAENQSLSEQLHNMHEELEREERDRSGVTLQNERLAEEIQRKTAENEQLVLENNKSRSDIRNLNVQVQRLMEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENKRLAEEVTQRLSEKELLAEDTSARLLEADSANSALQCKVKHLEEKLTLLSSEKETALATLEAEIVDLLTQLKGLNGTNSALESLCASKEKELVFLREHCELWTDPTTKKEKVITRHVKVFDGNEWMKLITDRPEALMSAFVIDAGNACHVPGDQIHEVSFLNNKEKH
Protein: Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) (F1QIH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, dendritic spine membrane {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00029429}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000256|ARBA:ARBA00029432}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00029432}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029430}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00029430}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00029428}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00029428}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004352}.
Interaction partners:
- V-type proton ATPase subunit d 1
- ATPase H+-transporting accessory protein 1b
- ATPase H+ transporting accessory protein 1a precursor
- Renin
- V-type proton ATPase subunit H
- V-type proton ATPase proteolipid subunit
- V-type proton ATPase 21 kDa proteolipid subunit c''
- Vacuolar proton pump subunit B
- H
- V-type proton ATPase subunit F
Sequence:
MLLRHDARRHAAGPGHVTGVARKRSPSENRPEMNRIIMNAVFALIGLLSGVLGDSLTVLRSPQYVTFRDEQWPISGEKIPDLVALTMGFSVREDLDWPGLAAGSLFQRPRANALIVVRGIDSLDFPKNVSSYPLENPVPFTLDSVANTIHTLFADSTPVVLQLAPSEERLYMMGMANTVFEDLPVTLQQIRGRLSQDGSVLTSLPLVSLSRNNEADLLFLSEVQVLYDISALLQKHKHLAKDPAPDLYSLELAGLEEIVRRYGTDSPQYTDAIRILTIALQKFADDVSSVYGNNAVVEVVTVKTFEVPLTRKSRSILESKQMSNPGSPYNLAYKYNFDYAVIFNIVLWLMIVLALAVIAISYNLWNMDPGYDSIIYRMTNQKIRLD