wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) (Q6P4R8)
Organism: Homo sapiens (Human)
Function: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.
Subcellular location: Nucleus {ECO:0000269|PubMed:18922472}.
Interaction partners:
- INO80 complex subunit E
- Actin-related protein 5
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Chromatin-remodeling ATPase INO80
- Actin-related protein 8
- RuvB-like 1
- TCF3 fusion partner
- Transcriptional repressor protein YY1
- RuvB-like 2
- Microspherule protein 1
Sequence:
MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ
Protein: Epithelial sodium channel subunit alpha (Alpha-ENaC) (Epithelial Na(+) channel subunit alpha) (Alpha-NaCH) (Amiloride-sensitive sodium channel subunit alpha) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) (H1AFJ5)
Organism: Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:23055064}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium {ECO:0000250|UniProtKB:P37088}. Cytoplasmic granule {ECO:0000250|UniProtKB:P37088}. Cytoplasm {ECO:0000250|UniProtKB:P37088}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P37089}.
Interaction partners:
Sequence:
MTDKEEEAEGGKKKEPMIGFYDSYQELFEFFCNNTTIHGTIRMVCSKHNNMKTVSWTILFITTFGVMYWQFGLLLGQYYSYPVSITMSVNFDKLIFPAVTVCTLNPYRYNVVSTQLANLDCYTEELLSTLYHYNPLTSGNQSACNSSSTAGTRAFDESYMKLEFLNDENTAYSGPVKGATNSTSPVNHTEFYRIGFKLCNATGEDCFYQTYSSGVDALREWYKFQYINIMAQIPSQSNQEDDSQISNFVYACEFNKVSCGVENYTRFRHPVYGNCYTYNDGQSATPWASFVPGVGNGLSLVLRTEQNDFLPFLSTVAGARVLVHDQNQPPFMEDSGLDIRPGVETSIGMKKEIISRLGGVYGNCTDGSDIDVVNLYNSDYNQQACVRSCFQATIVQQCGCGYYFYPLPSGAEYCSYSRNKSWGYCYYKLYKAFAADELGCFRRCRKPCQYTDYKMTAGYAQWPSSVSESWITSILSQENQYNMTSGRKNIAKLNVYFYELNYQTMGESPSFTVVTLLSNMGSQWSLWFGSSVLSVVEMGELVFDLIAVGVIVLRRRRREKCQASSDGEGTSDSTAGTHRGQENASRSGRDVACNRFVVVAEISPPPAYDTLQLDVPVACAPDCECTQHVSHASVHSQAPCSSQPEQEASEGPTVL
Protein: DH domain-containing protein (Q22354)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSAEAVSRKSSFVNSRILNRGSRNHPGLNGSDDAECRSNDSSLSVRDSWQYDEPSCSEVPDDGGTRRARSVTSSRISLFFGKETGKIEKEMFRILNQKKEDTDLEYPTYKLEKDWREIVHNHESLSDKSIKQQEAIWEIVTTEFRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQSIEPILAKSRETGEPLDVNYLQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESENFRDFVTWAEAQENLDRQKLIDTFSVPMQRLTRYNLLLKAVLKVTTDENEREMISNLVDCAESATAQLNKELNNNDLRAMLGDVMRTIEGPDYVDQDELERLFNLKLPLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHMGKMMFHYFADQNGFYLVHLTDFHTAQALYSMHTSGPEDTLRWTDMLKMALDEFKKIHRDSWSQQNQQESPLDEYGRGFIMEPSSFYSQRMLPPGYAQQQMPVIHRKCSSMDSQAVAAHAHLNYMHRSSAVSSTEQLDRHSGTDSMKCSPPRHKLSVASCHANPLSSSKSSVDLYVSLGAENGDIERPRSRSNSSGPEIEGLKQRSRSSSPDQKELGTPAQIGSPQTNTPCRDSPTLLITSDDCVEPLQFGRRFEKRYHTADGIDVLKPKISKLPGAILKRFSLNGGSGAVGSSCKKLESSKRNSQASNAASLDSFGSSTSGISTASSNNNDPSMETLTSKLSHISTISINDSPSSIDSQGTLSISLEAPPTVLEKDEDQHSIEVSVPPPPELPPPSKTPSPNLPTHKPNKSKVHCEELMKFIQDNRLETSDV
Protein: Elongation factor 1-gamma 1 (EF-1-gamma 1) (Calcium and membrane-binding protein 1) (Calcium phospholipid-binding protein) (CPBP) (Eukaryotic elongation factor 1Bgamma 1) (eEF1Bgamma 1) (Translation elongation factor 1B gamma 1) (P29547)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components. May be involved in transcriptional regulation of MXR1.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Elongation factor 1-beta
- Elongation factor 1-alpha
- Elongation factor 2
- Translationally-controlled tumor protein homolog
- Valine--tRNA ligase, mitochondrial
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein RACK1
Sequence:
MSQGTLYANFRIRTWVPRGLVKALKLDVKVVTPDAAAEQFARDFPLKKVPAFVGPKGYKLTEAMAINYYLVKLSQDDKMKTQLLGADDDLNAQAQIIRWQSLANSDLCIQIANTIVPLKGGAPYNKKSVDSAMDAVDKIVDIFENRLKNYTYLATENISLADLVAASIFTRYFESLFGTEWRAQHPAIVRWFNTVRASPFLKDEYKDFKFADKPLSPPQKKKEKKAPAAAPAASKKKEEAKPAATETETSSKKPKHPLELLGKSTFVLDDWKRKYSNEDTRPVALPWFWEHYNPEEYSLWKVTYKYNDELTLTFMSNNLVGGFFNRLSASTKYMFGCLVVYGENNNNGIVGAVMVRGQDYVPAFDVAPDWESYDYAKLDPTNDDDKEFINNMWAWDKPVSVNGEPKEIVDGKVLK
Protein: MBT domain-containing protein 1 (Q6P5G3)
Organism: Mus musculus (Mouse)
Function: Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q05BQ5}. Chromosome {ECO:0000250|UniProtKB:Q05BQ5}.
Interaction partners:
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT5
- MRG/MORF4L-binding protein
- Bromodomain-containing protein 8
- Mortality factor 4-like protein 1
- Enhancer of polycomb homolog 2
- YEATS domain-containing protein 4
- DNA methyltransferase 1-associated protein 1
- RuvB-like 2
- Inhibitor of growth protein 3
Sequence:
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAGNSAISVEGFSWGNYINSNSFIAAPVACFKHAPMGTCWGDISENVRIEVPNTDCSLPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRESQSASSKQKKKAKSQQYKGHKKMTTSQLKEELLDGEDYSFLHGASDQESNGSATVYIKQEP
Protein: Calcium homeostasis endoplasmic reticulum protein (SR-related CTD-associated factor 6) (Q8CGZ0)
Organism: Mus musculus (Mouse)
Function: Involved in calcium homeostasis, growth and proliferation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8IWX8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8IWX8}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IWX8}. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region. Colocalizes with ITPR1 (By similarity). {ECO:0000250|UniProtKB:Q8IWX8}.
Interaction partners:
- Splicing factor 45
- U2 snRNP-associated SURP motif-containing protein
- ATP-dependent RNA helicase DHX15
- Splicing factor 3A subunit 2
- PHD finger-like domain-containing protein 5A
- Poly
- Ribonucleoprotein PTB-binding 1
- Probable ATP-dependent RNA helicase DDX46
- U2 small nuclear ribonucleoprotein A'
- Survival of motor neuron-related-splicing factor 30
Sequence:
MEMPMPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQQQLICKQQAPELEPTSAMPPLPQPPLAPTASLTPAQGTPSMDELIQQSQWSLQQQEQHLLALRQEQVTTAVAHAVEQQMQKLLEETQLDMSEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLINDVLHHCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWEKNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQSLKTQHEEFVSSLAQQQQQQQQQQQQQPQPQPQPQIQLPQMEADVKATPPPPAPPPASAPAPTIPPTTQPDDNKPPIQMPGSSEYDTSAGVQDPAAAGPRGPGPHEQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRDAPWNNQPDPNWNNQFEGPWNNQHEPPPWGGAQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPPYPHRFDYPQGDFPADMGPPHHHPGHRMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGPSRSRSRSKSRGRSSSRSSSRSSKSSRSSSRSHSRSRSRSSSRSRSRSRSRSRSSRSRSRSRSRSRSKSYSPGRRRRSRSRSPTPPSAAGLGSNSAPPIPDSRLGEENKGHQMLVKMGWSGSGGLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDEFSTFGTRKEEKED
Protein: Uncharacterized protein (Q580J0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQIATVPSWNQLLPEKGGPRSDGTHAMRNVQGGEVLRGATSPGSTCGGHAAANFPLSDWEAEAVRRYRALKKGDLTAHSVTEYLHSSPIHGTLLQLVLHSKIVHITDWYERAGIVADWFSGGTPAPLCLLPSAVVHLVGSHQLTPSVAAGFLLRVAKLLLNAKTVSHAADSEKGQRSNVCVFTADGWSAAEVLQRSVYDLQESGLLTFEHFSSFFLRAALDKILIVGEEPELLLIPMCFLIRRCQKFSSDGWINSEERLRHLNRMCDTAGGLPTHIATTLTAII
Protein: MB2w3 protein (P70240)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISMILNEQESLIHRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTAPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: Transmembrane protein (Q38BK9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKRSDDVSGFTSFLMYSPTYALTLDVSIVLSCLLAIACRIKLFANKSACPCTVPSLKKTGNCGTSFVGNYVGHSTVAKDTVSDGRHNSMPEVLQSNDVTMNRSASPSAAKGGCSETHVSESLTDSKPCGHCSDDALGQLFGIPVNAFAATALINYLSLVSNCLTQYFRPSQVLYATLMSFCDVLLFAMSDYYGEGTSHCRHDKCVSHSDLCDGWRGLKLRIPSVPHELHDLKGIADHKSQRRGGSDPVYPFGVEASSLHLETRGNRWRLMILGFMRSNVDDASKPKHADGGVLSKLRVRWYILPILHTISVAALVILRKYQLLFFLGTAAGYVASCVTLHMVGYGLSALLSVLLFPFIGGGYYGTVRLSTNDERVEMLMGFFSLSGAVHVGGVGVYYVLQQTFSGVCVVLYVLMLLEEDDALYSTHVSLMRWYVNPCGQGLLDAQKLFTFLLLLGSMNRHKQRERLLARYRKNFSSHLL
Protein: Nudix hydrolase 22 (F5H1N0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDPEVTLLLQCPGGGLPQEQIQAELSPAHDRRPLPGGDEAITAIWETRLKAQPWLFDAPKFRLHSATLAPIGSRGPQLLLRLGLTSYRDFLGTNWSSSAAWLRQQGATDWGDTQAYLADPLGV
Protein: Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (O08679)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14741102}; Peripheral membrane protein {ECO:0000269|PubMed:14741102}. Lateral cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q7KZI7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7KZI7}. Note=Phosphorylation at Thr-539 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm. {ECO:0000250}.
Interaction partners:
Sequence:
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKVPASPLPGLDRKKTTPTPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPFGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGGGGTDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q7Z637)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRSLDSARSFLERLEARGGREGAVLAGEFSKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKRGAPAGAGSGTQTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSPAGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV
Protein: COP9 signalosome complex subunit 6b (AtCSN6b) (Signalosome subunit 6b) (Q8W1P0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- COP9 signalosome complex subunit 5b
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 5a
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 7
- COP9 signalosome complex subunit 1
- NEDD8-like protein RUB3
- COP9 signalosome complex-related / CSN complex-like protein
Sequence:
MAPSSSSGLTFKLHPLVMLNISDHFTRVKTQLNPPAASCATGNGSNNADAMLLQNPRVYGCVIGLQRGRTVEIFNSFELIFDPALDTLDRSFLEKKQELYKKVFPDFYVLGWYSTGSDATESDMHIHKALMDINESPVYVLLNPAINHAQKDLPVTIYESEFHVIDGIPQSIFVHTSYTIETVEAERISVDHVAHLKPSDGGSAATQLAAHLTGIHSAIKMLNSRIRVLYQHIVAMQKGDKPCENSVLRQVSSLLRSLPAAESEKFNENFLMEYNDKLLMSYLAMITNCTSNMNEVVDKFNTAYDKHSRRGGRTAFM
Protein: Killer cell lectin-like receptor subfamily E member 1 (Q8CJC7)
Organism: Mus musculus (Mouse)
Function: Lectin-like receptor for natural killer (NK) cells. Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner. Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation. Plays a role in allogeneic recognition by the immune system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12782717, ECO:0000269|PubMed:14707119, ECO:0000269|PubMed:15069013, ECO:0000269|PubMed:18713988}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Killer cell lectin-like receptor 7
Sequence:
MDEAPVTRSTLNVNSQQKSKAKNKIKNTLNSNELSSIEQRKKYQKHLKKHKNTAEDISGKGNCSPPWRLLSSVLGAMCLLLMAVAMVMTTFTTKSSSERSSSTIQQEGLHHPCPENWVWFRCSCYFFSKEELIWRDSQRACLSLNSSLIRMNKEEMNFFSLKSFFWVGVYYNETRRQWLWEDHSVLPSGLFSKLEANMKNFCASYKSKEAYMEENCANKLTYICKK
Protein: Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) (P23977)
Organism: Rattus norvegicus (Rat)
Function: Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q01959}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01959}. Cell projection, neuron projection {ECO:0000269|PubMed:32963038}. Cell projection, axon {ECO:0000250|UniProtKB:Q01959}. Note=Localizes to neurite tips in neuronal cells (PubMed:32963038). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:32963038}.
Interaction partners:
- D
- Syntaxin-1A
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Alpha-synuclein
- Synaptic vesicular amine transporter
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Protein kinase C beta type
- Protein kinase C gamma type
- Tyrosine 3-monooxygenase
- D
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
Protein: 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (Protein Rpn7) (Q9V3G7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 7
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-5
- Proteasomal ubiquitin receptor ADRM1 homolog
- GH11341p
- 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 2
Sequence:
MPAENLEEQGLEKNPNLELAQTKFLLTLAEYKQDAALKAKLLEAIRTENMAPWYEHICSELGWTVDKDLLARMKENNRVEVEQLDAAIEDAEKNLGEMEVREANLKKSEYLCRIGDKAAAETAFRKTYEKTVSLGHRLDIVFHLIRLGLFYLDHDLITRNIDKAKYLIEEGGDWDRRNRLKVYQGVYSVAVRDFKAAATFFLDTVSTFTSYELMDYPTFVRYTVYVAMIALPRNELRDKVIKGSEIQEVLHGLPDVKQFLFSLYNCQYENFYVHLAGVEKQLRLDYLIHPHYRYYVREMRILGYTQLLESYRSLTLQYMAESFGVTVEYIDQELARFIAAGRLHAKVDRVGGIVETNRPDNKNWQYQATIKQGDLLLNRIQKLSRVINI
Protein: Cytochrome b6-f complex subunit 4, chloroplastic (17 kDa polypeptide) (Q84TU6)
Organism: Euglena gracilis
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:12837550}; Multi-pass membrane protein {ECO:0000269|PubMed:12837550}.
Interaction partners:
Sequence:
ESALERRSSSVVMNNVMKKPDLSDPKLRAKLAKGMGRNYYGEPAWPNDLLYMFPVCILGTFAAIVGLAVMQPTPTGEPANPFATPLEILPEWYFFPTFNLLRVIPNKLLGVLSMAAVPAGLITVPFIENVNKFQNPFRRPVATSVFLLGTVVAIWLGIGATLPIDKAISLGFW
Protein: Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (Forkhead activin signal transducer 2) (Fast-2) (O88621)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Subcellular location: Nucleus.
Interaction partners:
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 3
- Dr1-associated corepressor
- Homeobox protein Nkx-2.5
- E3 ubiquitin-protein ligase TRIM33
- Homeobox protein MIXL1
- Homeobox protein goosecoid
- Cryptic protein
- Nodal
Sequence:
MASGWDLASTYTPTTPSPQLALAPAQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYQPPSPPPPPREGFSIKSLLGDPGKESTWPQHPGLPGQSTAAQAGTLSKGEEGMGTGPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLEDSADSRGVPRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPTTSCPQCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM
Protein: Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (Q65819)
Organism: bovine alphaherpesvirus 1
Subcellular location: Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Virion tegument {ECO:0000256|ARBA:ARBA00004535}.
Interaction partners:
Sequence:
MSGRIKTAGRALASQCGGAAAATMDPYDAIEAFDDSLLGSPLAAGPLYDGPSPARFALPPPRPAPLAALLERMQAELGFPDGPALLRAMERWNEDLFSCLPTNADLYADAALLSADADAVVGAMYLAVPGDAERLDLNAHANQPLPAPPASEEGLPEYVAGVQAHFLAELRAREERYAGLFLGYCRALLQHLRATAARGRGAAGAGAQADRLRQLVAARYYREASRLARLAFAHMYVATAREVSWRLHSQQSQAQGVFVSLYYAWPQRRQFTCLFHPVLFNHGVVALEDGFLDAAELRRLNYRRRELGLPLVRAGLVEVEVGPLVEEPPFSGSLPRALGFLNYQVRAKMGAPAEAGGRLAPEREHSYARPRGAINYGTTPEAMLRPPSPSEVLPCDPAPAATVRVASPATHLAQAPSAKGAAPAEFAALAGLAKPGPAPLAAAPAQAPFAAALALAEPAAALAPAPLAAAPAEPAAAVAGPSPANPFGGTYDALLGDRLNQLLDF
Protein: Uncharacterized protein (Q38AE2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTSKAVSVASLPPFVLWRCATATVPHCHLFGLNVASPHTCYDRCMLSKPVAPLLHQSCFAAHCCVGVVRSPCRGQMWGEPVWTCRLLLAECGRSAAPSPQTMAICSQEMLALKCRGLPFVEYSVNNLREGSLVHVVSKIYKKPRFVPIHGTYVEDTELVVTEQFGSLVLLGHL