wanglab/gogpt-training-data huggingface dataset:
Protein: Integrin beta-like protein A (109 gene 1 protein) (Q54KF7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Implicated in cellular adhesion to substrate or phagocytic particles.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Talin-B
- Putative phagocytic receptor 1a
- Membrane-associated sulfotransferase kil1
- Substrate-adhesion molecule
Sequence:
MNRILTLFILFISLFIVCEATHFRFGTMSWMPMGSHNTIKFSSNYAFRIGFFKKFNKGCNVGDVVKVGDLDLGDDKTKVDVNLVVTSVNQADDWFTGEFSYTHTYNPIKLGGKAVTYKVVFTDCCRIKSLLNNAEGSWYISTSVVVDPNQGSDVSTFNRSPVSGMVPIITLNRDKNNQFLIAASDPNGDTLTYSLSNAYTMNQPSGLSIDSSKGIVSFKPTVSGFYSTQIMIKDTKGAYVVVDFLINSVIEPGVCHPSCSNGGNTCNGNSGCKSCKGTDSNGNTCSSFPPVFVYPPTPTDGSLLAYEVNKTNSFSIQCKTEEKSKTVFIQPANIPLAATLTSSDQNKQVSTLTYSMLPQLKHIGVYVISAYCTDNKGLVSTITSFSISVEKPICGHGTNKPGGGCNCETGWDPEKNCYECLKGHYGEKCDPVDPCVNGESNEGSQGNGKCTCYYGWEGKNCDIKVNQVCNANKENVVLDSSVAKSSYINPNFAQVYLNTDPSKQALTLSSKLSIPETIDKFEVLVLVDSQPSIVEYWDNFKKYSSDLTKNLQDISETVSIGLGLFSDAKTNGYSFVLKKSIGNGLSGLDDKDKAPASSYSTKNSLIALTSAAEFPAGWSTGSIKIIVLLTDNDYSATAQEVSKFTSTLISKSILPVVVSFNDNQNWDTLFKNQGFGSTKKTSNAKGNDWVSVATSAIKDVLSKAVVKAIDDTKGFLTLPSATTISIEDSKDYTIPIQIKYPQGQSDIPQNPSVSYSVVGFGITRIVINYNSAPTALGYSIETKQNVNYNFKLSGSDVDGNTLTIKFKTIPAASVGVIQADGVTIEQGDSFSIEKTFTFKPATNYYTKSTNDKFTFVANDGCLDSNEATVEIKITHVNQAPSCSSLSGSAISVTGLNTPKSFSLQGSDIETDSNLKIVFGDLTAISAYGNIKSGSNVVSTGSSVQLSSGSASLTFTQTKDIANDKEITVDFKVNDGSLDSSSSCSFKVKFVHFNKPPVAFAVTPLTIRQNSELKITISASDSDSDSVIFTLDDLKLGGGDSFFKCDDRSQLTAPFTTQPVSISGGVASFSEICYSSPLVNANSYASLVFFANDGQLSSDKFKVLININGDRPNAPPVVNQIPNFTMNEDDISNELVIDGIDPDELDQGKLKGIIIQKPTNGVILVKSGSSTSEAPIIGNAPYKIFYKPNPLYYGTDSFSYTVEDSMGERDATPKTTQITVQHVNHAPTLSIDPYDFTSQTSEKTLELTPKDIDLIDTVFHCTIVKLPATAIIKTSAGKVIDTVPTDLSDNKYIITSNNNIYNDFSDSFDAKCYDSSNAVSNIATGPITFRYINVPPKAESSDETLNQDSSVSFSVKATDLEDNSNVRAVIRSLPAKGTLTIKSTGKAAEISSTYAIDDFVYTPVAGYSNWDKPGHVGPADSFNFVAKDSKNDISSNIGTVSFFIEPRNPPTYEGLAVLYTKENTDLPFSISGIVGNGGSNVFLRIKSIVSRGSLYATHCMGTEGCMSEPNPVDININFTSQPYTFSFTPIEYENGDNYAIIEFVLYDKFNGQEVESQKYTIIINVIPVNQAPEVILIEHTLSTLPNNVIAFDKFKTVKMETNSYVIIKYDGTDIDDPKEKLKSYIVSPPLRGLLYVYDKDAKDGLGKLIKKDDTFVPVAQDGFWYIVFVPTPGSSGDGYVRIPISMVDFLGDISVPVTVAVDVSKKNIPPFITIENKNYTSLANTSIVVTGVSFDDPDSKYNDVELILSLVNKDGDLVSNKIATFSLSQQSKAKCTKHSEFAQFTCRSNKKTLNALISTMYVNHQGGGSYRLKVFVNDLGYSSPASIRDKNHMTATDYVELDVTKPEVTTTKENNNKTVLTGAIAGAAAGAGLLAAGAWFLLKKSAPPTDAFFGEGAFADGAVSTNPMYEESGRSAINPLYEASSENL
Protein: Fanconi anemia group F protein (Protein FACF) (Q9NPI8)
Organism: Homo sapiens (Human)
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11063725, ECO:0000269|PubMed:18550849}.
Interaction partners:
- Fanconi anemia group C protein
- Fanconi anemia group M protein
- Fanconi anemia group G protein
- Fanconi anemia group B protein
- Fanconi anemia core complex-associated protein 100
- Transcription factor HES-1
- Fanconi anemia group A protein
- Fanconi anemia group D2 protein
- FA core complex associated protein 20
- Centromere protein X
Sequence:
MESLLQHLDRFSELLAVSSTTYVSTWDPATVRRALQWARYLRHIHRRFGRHGPIRTALERRLHNQWRQEGGFGRGPVPGLANFQALGHCDVLLSLRLLENRALGDAARYHLVQQLFPGPGVRDADEETLQESLARLARRRSAVHMLRFNGYRENPNLQEDSLMKTQAELLLERLQEVGKAEAERPARFLSSLWERLPQNNFLKVIAVALLQPPLSRRPQEELEPGIHKSPGEGSQVLVHWLLGNSEVFAAFCRALPAGLLTLVTSRHPALSPVYLGLLTDWGQRLHYDLQKGIWVGTESQDVPWEELHNRFQSLCQAPPPLKDKVLTALETCKAQDGDFEVPGLSIWTDLLLALRSGAFRKRQVLGLSAGLSSV
Protein: NAD(+) kinase (EC 2.7.1.23) (A0A8I6AKM0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
VIHPHSLEPRAWHIQDPASQRLTWNKSPKSVLVIKKIRDASLLQPFKELCIYLMEENNMIVYVEKKVLEDPAIVGDENFGPVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFNFENFQSQVNQVIEGNAAVILRSRLKVRVVKEPRDKKTAIHNGLSENGLDTEGGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMVHPNVPAIMVTPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVCDPVSDWFESLAQCLHWNVRKKQAHFPEDEEDQDEEDS
Protein: Probable transcriptional regulatory protein Mce1R (Probably GntR-family) (Q79G00)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Mce-family protein Mce1A
- HTH-type transcriptional regulator Mce2R
- Probable fatty-acid-CoA ligase FadD5
- Mce-family protein Mce2A
Sequence:
MNAPLSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLAWFLLNAARYMGAGVRGRPAMGRGRGEQSSAADRRAAPPRHSRRNRAHRLAVHRWGTQADGGPG
Protein: SEC14-like lipid-binding 8 (A2BIR0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Tetratricopeptide repeat domain 39B.
- Inactive all-trans-retinol 13,14-reductase
- Perilipin 6
- Fatty acid hydroxylase domain-containing 2
Sequence:
MSGRVGDLSVKQAEALAQFREKVQDVLPQCPSQSDHFLLRWLRARNFNLQKSEAMLRKHIEFRKHMKVDTITTEWQVPEVIDKYLSGGMCGHDREGSPVWYDVIGPLDPKGLMHSASKQDLIKSKVRDCEILQKDCDRQSERLGRNIESITMVYDCEGLGMKHLYKPAIETYGEVLTMFEDNYPEGLKRLFVIKAPKLFPVAYNLVKHFLSEDTRRKVIVLGSNWQEVLQKYIDPEELPAYYGGKLTDPDGDPKCRTRITFGSEIPKSYYVRDSIKVDYEQSVSIGRGSSHQMEYELIAPNCALRWQFSCDGADIGFGVYLKKKMGERMKAGEMREIVPNQRYNAHLVPEDGSLTCPEPGVYVLRFDNTYSVFQSKTVKFTVEVLLPSQVNQSDN
Protein: WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) (Q9EPK5)
Organism: Mus musculus (Mouse)
Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (By similarity). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:21145499}. Cytoplasm {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:21145499}. Cell membrane {ECO:0000250|UniProtKB:Q9GZV5}. Cell junction, tight junction {ECO:0000250|UniProtKB:A0A8I3PQN6}. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (PubMed:11118213). When phosphorylated is retained in the cytoplasm by YWHAZ (PubMed:11118213). Can be retained in the nucleus by MED15 (By similarity). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (PubMed:21145499). In the nucleus, phosphorylation by PRP4K induces nuclear exclusion (By similarity). Interaction with AMOTL2 results in localization to the cytoplasm and tight junctions (By similarity). {ECO:0000250|UniProtKB:Q9GZV5, ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:21145499}.
Interaction partners:
- Transcriptional enhancer factor TEF-3
- Transcriptional enhancer factor TEF-1
- Serine/threonine-protein kinase LATS1
- Angiomotin
- Serine/threonine-protein kinase LATS2
- Transcriptional enhancer factor TEF-4
- Transcriptional enhancer factor TEF-5
- Transcriptional coactivator YAP1
- Tight junction protein 1
- F-box/WD repeat-containing protein 1A
Sequence:
MNPSSVPHPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKVMNQPLNHVNLHPSITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPTQNQPTGLMSVPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNTPAMSTDMRSVTNSSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDTGENSGQTPMTVNPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL
Protein: Protein FAM161A (Q8QZV6)
Organism: Mus musculus (Mouse)
Function: Involved in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22791751, ECO:0000269|PubMed:22940612}. Cell projection, cilium {ECO:0000269|PubMed:22791751, ECO:0000269|PubMed:22940612}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22791751}. Note=Localized in the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium. Localizes to the inner scaffold in the central region of centrioles. {ECO:0000250|UniProtKB:Q3B820}.
Interaction partners:
Sequence:
MNFSDIYHSDEEYFRKLKDLKAVHEETMSKLEKMYQDKLNIKDIQAGFIRDGISDSSSSSASEKSCSHPALSVTSLSEPDLDGSSSLSTTTDEGLPDLEEKTPGESSAMVHAQELINNMWNDFSVEDYIQYDSDSRTAKKKRKKAKSLTPKITVPVPFEMTVREQNRREKALSARSDLETKLLKRDEDDAECKKKFRANPVPSCVLLPLYEDLVKQSEERRKKARERNRAALLASLKPFKFIAREEQKQAVREKKLRDLFRAKRKTNQFKAKPVPRFIYRPAASDKPKEEELYGDSRMLPKVRDLLQNSPWPSRSACRRFRDPRSPAKPRGKHRRRCLRRDGDLEKWKEPFSEYSFLKCPMLCEECCLHESPCDSDKRQKLLADIRADEEILRETRRPGRSPRRKSPGRSSNPKPRPHECSPPMPTASSRGREQAIRRSEKARMREYWQELEEQEEKLQKRPMLFERVTQVVFIG
Protein: Insulin-like growth factor-binding protein 1 (Q3HWG3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Insulin-like domain-containing protein
- Thyroglobulin type-1 domain-containing protein
- Insulin-like growth factor 2
- IGFBP N-terminal domain-containing protein
- Insulin-like growth factor 1
- Cystatin fetuin-A-type domain-containing protein
- Secreted phosphoprotein 24
Sequence:
MLGLYKKLTLLAAMSLSLLTTLAQSSPVVGPEPIRCAPCTQEKLDECPAISPDCKQVLREPGCGCCMACALEKGASCGVYTAHCAQGLKCSPRAGDPRPLHSLTRGQAICTEDQGQEKVEGVPDHSSLAYFLGLNTPFDTKNEGAQESIKAKVNTIRKKLEEQGPCHIELHAALDKITSSQQELGEKFTNFYLPNCDKHGFYKAKQCESSLVGPHARCWCVSSWNGKKILGSNYLPGLECQLEL
Protein: mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41) (Q3SWS8)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P78406}. Note=Recruited from interphase nuclei to spindle MTs during mitosis. {ECO:0000250|UniProtKB:P78406}.
Interaction partners:
- Nuclear pore complex protein Nup98-Nup96
- Nuclear RNA export factor 1
- Tip-associated protein
- Nuclear pore complex protein Nup153
- Tip-associated protein
- Nuclear RNA export factor 5
- Tip-associated protein
- Nuclear pore complex protein Nup85
- Nuclear pore complex protein Nup155
- NKG2-D type II integral membrane protein
Sequence:
MSLFGTTSGFGTGGTSMFGSTTTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPVAACGFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK
Protein: Transmembrane protein, conserved (Q4GZ48)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- SNF2 DNA repair protein, putative
- RuvB-like helicase
- RuvB-like helicase
- Histone H2A
- YEATS domain-containing protein
- Uncharacterized protein
- YEATS domain-containing protein
- Histone acetyltransferase
- histone acetyltransferase
- histone acetyltransferase
Sequence:
MEKQLFAILSSGSRKGGSAGERRQAFSTAFEASLFSTTYNEPASAKKGSKRPKATDKETREDECLRHAVNSFFTMPTPGPLETFFLRAAAMLHSYTLLLPEKDGEAGELPGVVKEAAIAFSSAIFAPRLRAACESLKVEEKCSAWVSTNNCGAGAEALNHPLWHCFLCIFLQQLSARGGSIASWRKFISDCADGSHASAHPQEGDCGRDESEEDKGSSTNITCEDECTRLAVAAWGAVSLKLLDATVGRTRYRRTAVLCRSVCPHIVAQAPGTTYQLLDILHGFMSAWRERYSKASSNGREGKKEDDDNTEDETGATIVTLYAERLGHIVGDGQTHAMLLVTAIGAVLSATYVLPKRQRHGTVGSGDPSKWYPPRCEDPSLGLTESEWRATHFPPIGRLLQCLHIHSLLSVHVFAFCMQLRIGLSSSQHAEVRQRLALCFYLTEVCPVHVALAIYYYATSPQNALAQGSGELPGDGLMAYTKALDHFVTAAHSELLFSVTDLPTGRRRQRHNTRAASGTKDGGPDDDDDDEPTAVDGELKGPRFTKMEFPVSCPTWSQYLTEGTAGKATSGPAGPATKPVAGTLQVAPCRFVVELLEIGLPMLSGATIHLLQNEMDMDVCAVSTAAMPAECGRGVAAIIMDHFHSIFSRTNPSTACVGPLPTERHWNTSMIRVLGEYLPLLEAVYGYVASQSFISFVLEQITKGCKDFLSAVLDRHSCSTDESKQSVQALARKALALAERYLITVVMPCMRVMSPSPIVYDRLQALFNLFKEEAPKVSFGTSPAEFLHTSVFCSALLATGVSNDTLSYRAPHERLRSKELDALFTQSLKRLTLGNVNRYRCMLRPSIYANPLLAAEKMFKQAVGYNNNFLLIHTQLLRGAPPAVMTLIAHMGLHHMQHYAENERFGTADSTRVSCIATFLAVLWRENPNSFDGGLLLRAAEHSLRREGRASVVFGLELLRAILHELLDTKLEHEGKFTPEQLQALVAPHRTQWFVKGAAESFRCGRWDSTFTPVVLSASEANLRSALQQRCIIPAEKESSDDDAAAANCGDGTTCNDNEEKKEEEVAHNNTTEDQQCGGSWSSVVEVTLGQAILLHLCRLHSRIYAVQSDLSAPMQLLLLTCARDYNVINDLLLCMETLLTQGPPPKEIYMVAMPHIALRLTARFAANGIVRQRPEQKHNGHLAATEPSHCEGDANNHHLCATVESIFTVMPAEIGDHMGDMASLCNMGGNISFALLQKLSCYTAAHFVFEESVYVAAGKELNRFYVIGNKKQKNRDDVPNTGVNVQKECFLLWMQEQTRQLRYERESHRTLYQRSAESLGQLLDELRSGGVLTEPVEFAKAYLLPRALISLEDTLFVFHFLSWMLNSTEGDERNRVIDIALSLVTAGMSFFVGLTDGECMRLGVLLSFLLTLVEDCAIDLSGNTGASDSDEGTGGGSAADGAASTYQPPGITAEALRAHLDPEARTFLNVLSARVQEEDEKGDEEADNQVQEGPTAPSYSKVAAYPLQLEAYLCRALVQVLVHQWDVQYLHRNAFIVLEHLTKGKHRFPSTLCAADWLITVVSLHAVKSSSSYASATAVLQALKENRQRRCELVERRKSAGNSVKKTNRWLKLLKDREEFMQLLLAPDMAAAEKKICEREAVIASSVALADAEGDEEGAVAVEEGAVNDNVEKNEEPNESEGAEDLDDNSDAADDAHSSVTGDRRGSSGGESSFEEEEEGEDEERSPSASASHGDPNHGSITDGKGRNSTSPPPEEPEANEVANAKSRKRPREGSVERTGGEEET
Protein: Target of ERK kinase mpk-1 (H2KZH5)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24961802}. Nucleus {ECO:0000269|PubMed:24961802}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24961802}. Midbody {ECO:0000269|PubMed:24961802}. Chromosome {ECO:0000269|PubMed:24961802}. Note=Before first cell division of the Q neuroblast lineage, localized diffusely in cytoplasm and concentrated in the nucleus (PubMed:24961802). Around metaphase, localized to the centrosomes and subsequently inherited by both daughter cells (PubMed:24961802). Before anaphase, localized near the region of the membrane that eventually forms the furrow and as anaphase continues, concentrated within the furrow and remains there, eventually localizing to the midbody (PubMed:24961802). During telophase, localized to chromatin (PubMed:24961802). {ECO:0000269|PubMed:24961802}.
Interaction partners:
- DEP domain-containing protein
- Arf-GAP with ANK repeat and PH domain-containing protein cnt-2
- Maternal embryonic leucine zipper kinase
Sequence:
MSSSRHFSIPYDEDVVHSVILENTPSPPPKPPRGILRKEAPMKPQRSALKIEPARDDDKENNSQPQARSQFKAKDTMEQMQSYFKRSISVLRKSEEHFTGAEAADILTAYIETHRNEFPRDNIGRSNAVKLLEIWLESNTIQSVESHQKKFVDSERTFYRLGGDSESLYIVNTPIASRNHDDSASVSRSESSRRSNSIKRLFSPFVRRNRSNSRGRDKDKDNLKDGSSTNLKSTWSLFSSSSEKNEKKLKKAEQQLIKEEEAEVYELSLFHLLSLIDVEFLEDVALPVQDSKNNASFLSSILGKVGLGASEERLDPHQEDHMDLLIETHPLIRDASQWFQMARCCAPLLYFEAKPVASNHKTSHNEQLYLWCRAALDAVKNRLEKMTQNGSSPLFPSEFAPLLTKIAQQLINDMDSGEKLSTAVMYIFLMVPHPIRKTIDQLVQWLQLTMRTDAVEDLRSPYYLGKKDPRRYKENVNVIIGELSSFIFPRGCMTNVQQDIFIETLVELRQKGKLGQRPAQLESSLRAKSVNGQIKWQRKERKHNSLEGDLTPVRYTVRRESIRSKTSKSKDGLNETDSALVTMINSVIDNKELSLTEKKKQLMNFKKFYPKLYNDFFPGMI
Protein: PER1 protein (Q6IN51)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGPLEGADGGGDPRPGESFCPGGVPSPGPPQHRPCPGPSLADDTDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQSPSPPSSSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRELKLRLPPERRGKGRSGTLATLQYALACVKQVQANQEYYQQWSLEEGEPCSMDMSTYTLEELEHITSEYTLQNQDTFSVAVSFLTGRIVYISEQAAVLLRCKRDVFRGTRFSELLAPQDVGVFYGSTAPSRLPTWGTGASAGEVPKRCGEA
Protein: Uncharacterized protein (Q9D431)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MQDEPQVLVAELHRRALVEYVRPLLRGRLRCRSARTRSRVAGRLREDAAHCSGCFGGWSPRLIGLTKWCHTWQRSYSWRTLRASRWRSGCWCGTTQTSGGSMWQPSLTSEVFETQLPVRRSWRWPGTWNYLKVVPYHPLGTVPSLPTSLCPAHLSVLASLSSWDASQCPGWPGPIWLVCPCGLVLHHQLEPEPIAEAPGAHVAADRPSSLPRDSLPETPTSGIGGSLDNPPSPEHPLQKGN
Protein: THO complex subunit 1 (Nuclear matrix protein p84) (Q8R3N6)
Organism: Mus musculus (Mouse)
Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:32776944}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16705185}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:32776944}. Note=Predominantly localized in the nucleus (PubMed:32776944). Shuttles between the nucleus and cytosol. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution (By similarity). {ECO:0000250, ECO:0000269|PubMed:32776944}.
Interaction partners:
- THO complex subunit 6 homolog
- THO complex subunit 5 homolog
- THO complex subunit 3
- THO complex subunit 2
- THO complex subunit 7 homolog
- Spliceosome RNA helicase Ddx39b
- THO complex subunit 4
- Aly/REF export factor 2
- SAP domain-containing ribonucleoprotein
- THO complex subunit 2
Sequence:
MSPTPALFSLPEARTRFTKSTREALNNKNIKPLLTAFSQLPGSENEKKCTLDQAFRGVLEEEIINHSACENVLAIISLAIGGVTESVCTASTPFVLLGDVLDCLPLDQCDTIFTFVEKNVATWKSNTFYSAGKNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLENVTVFNTNEQESTLGQKHTEDREEGMDVEEGEMGDDEAPTTCSIPIDYNLYRKFWSLQDYFRNPVQCYEKISWKTFLKYSEEVLAVFKSYKLDDTQASRKKMEELKTGGEHVYFAKFLTSEKLMDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPPDGERFSKMVEHILNTEENWNSWKNEGCPSFVKERASDTKPTRVVRKRAAPEDFLGKGPNKKILIGNEELTRLWNLCPDNMEACKSETREYMPTLEEFFEEAIEQADPENMVESEYKAVNNSNYGWRALRLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPPPSEEIKTGEDEDEEDNDALLKENESPDVRRDKPITGEQIESFANKLGEQWKILAPYLEIKDSDIRQIECDSEDMKMRAKQLLVAWQDQEGVHATTDNLISALNKSGLSDLAESLTNDTETNS
Protein: Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt) (T-complex expressed gene 2 protein) (Q9JIK9)
Organism: Mus musculus (Mouse)
Function: Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25816300}.
Interaction partners:
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS3m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS11m
Sequence:
MARKKVRPRLIAELARRVRALREQRNQPRDSQLYALDYETLTRPHSGRRLPVRAWADVRRESRLLQLLARLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYTAQNLDHGRAWGILTFKGKSEDTAREIEQVMYHDWRLVPKHEEEAFTAFTAKPEDRLNSVPYPPLLRAMILAERQKNGDTSVQEPLLNLERTRMRPWDYPAKQETKGRAKGTPV
Protein: Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) (Q96N96)
Organism: Homo sapiens (Human)
Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Subcellular location: Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cell projection, podosome {ECO:0000250|UniProtKB:Q5DU57}. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. Localized to the core of myotube podosomes (By similarity). {ECO:0000250|UniProtKB:Q5DU57}.
Interaction partners:
- Adenomatous polyposis coli protein
- Cell division control protein 42 homolog
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 3
- Rho guanine nucleotide exchange factor 4
- Adenomatous polyposis coli protein 2
- Neurabin-2
- 14-3-3 protein epsilon
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQVPPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCPVAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK
Protein: Alanine-tRNA ligase, putative (DUF760) (At1g48450/T1N15_5) (T1N15.6) (Q9LP80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g52960
- At4g33110
- At1g63610
- Electron transporter, putative
- Pentatricopeptide repeat
- AT3g29240/MXO21_9)
- Thioredoxin domain-containing protein
- ARM repeat superfamily protein
- Uncharacterized protein At3g49140
- MAR-binding filament-like protein
Sequence:
MDAVAANLFQSPSLLRQTSERLIFSTPNCPGFMRISSGPQFRLRQNSSLKFSRPFQSGTTCVKSRRSFVVKASASGDASTESIAPLQLKSPVGQFLSQILVSHPHLVPAAVEQQLEQLQIDRDAEEQSKDASSVLGTDIVLYRRIAEVKEKERRRALEEILYALVVQKFMDANVTLVPSITSSSADPSGRVDTWPTLDGELERLHSPEVYEMIQNHLSIILKNRTDDLTAVAQISKLGVGQVYAASVMYGYFLKRIDQRFQLEKTMRILPGGSDEGETSIEQAGRDVERNFYEEAEETYQAVSSNQDVGSFVGGINASGGFSSDMKQSRLKTYVMSFDGETLQRYATIRSRESVGIIEKHTEALFGRPEIVITPQGTIDSSKDEHIKISFKGLKRLVLEAVTFGSFLWDVESHVDSRYHFVLN
Protein: Rho-N domain-containing protein 1, chloroplastic (Q94K75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to and supports processing of specific plastid RNAs. Associates via its C-terminal Rho-N domain to single stranded regions of 16S and 23S rRNAs or to rbcL mRNAs. May be involved in targeting transcripts to RNases such as RNE or RNase J.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:22735703}.
Interaction partners:
- Ribonuclease E/G-like protein, chloroplastic
- Ribonuclease J
- Rho termination factor
- Rho termination factor
- Transcription termination factor MTERF6, chloroplastic/mitochondrial
- Chloroplast stem-loop binding protein of 41 kDa a, chloroplastic
- Ribonuclease II, chloroplastic/mitochondrial
- Ribulose bisphosphate carboxylase large chain
- Endoribonuclease YBEY, chloroplastic
- Transcription termination factor MTERF8, chloroplastic
Sequence:
MAMSGTFHLTSDYVPGYTLSDSRCFFNSAVSRRTLAILPCSSCLDHKNGRLKSVPNRSSFVCRASSGGYRRNPDFSRLNKHGYRGNNRQSGGREDFDIENSDMLSSRNGPLFNLSSSPKFQATSSPGPREKEIVELFRKVQAQLRARAAAKKEEKKIEEASKGQGKESETVDSLLKLLRKHSGEQSKRQVSKFSSQGEVQGDTVDKQDRTGNLVTSGNKDNNASSFTRPTSSFRRKSPVPRSQSPPAYSSEATFDQSSSYSVTWTQKKDTVELHDEPEHEPAYEHEHEPENESEPGPVTTMLEPDSELKPESSSFYQEEEDDDVTFDVLSQDDGILDVLSDDDESLDDADEDSDEAEEEAVKDLSELKLVELRGIAKSRGLKGLSKMKKAELVELLGSDSS