wanglab/gogpt-training-data huggingface dataset:
Protein: Prohibitin-1 (P40961)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Has an antiproliferative activity. Regulates replicative life span.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10207067, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15525670, ECO:0000269|PubMed:38964378}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15525670}; Intermembrane side {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15525670}.
Interaction partners:
- Prohibitin-2
- Mitochondrial inner membrane m-AAA protease component YTA10
- Mitochondrial inner membrane m-AAA protease component YTA12
- Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
- Protein UPS2, mitochondrial
- Protein UPS1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- mRNA-binding protein PUF3
- Mitochondrial inner membrane protease ATP23
- Lon protease homolog, mitochondrial
Sequence:
MSNSAKLIDVITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAIIYDVRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERAKFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNVVYLPSQHSGGGNSESSGSPNSLLLNIGR
Protein: Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) (P20618)
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 7
- Proteasome subunit alpha type-6
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 12
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- 26S proteasome non-ATPase regulatory subunit 2
- Proteasome subunit beta type-9
- 26S proteasome non-ATPase regulatory subunit 14
- Proteasome subunit beta type-8
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
Protein: Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) (Q5UR82)
Organism: Acanthamoeba polyphaga mimivirus (APMV)
Interaction partners:
Sequence:
MQKFFVTSALPYPNNSSPHLGNLVGALLSGDVYARFKRNQGHEVIYLCGTDEYGTTTMIRARKEGVTCRELCDKYFELHKKVYDWFNIEFDVFGRTSTTKQTEITWEIFNGLYNNGYIEEKTTVQAFCEKCDMYLADTYLKGYCYHDGCRENRVISNGDQCEICQKMIDVNKLINPFCSICLTPPIQKSTDHLYLSLDKLTPLVQQYLDRVEFDSRIMAISKAWLEIGLNPRCITRDLEWGTPIPINLDPKLEKYADKVFYVWFDAPIGYYSILANERDDWREWLNSGVTWVSTQAKDNVPFHSIVFPASVIGSNIELPLIDRICGTDYLLYEGQKFSKSQGVGLFGDKVAEISPKLGINEDYWRFYLMKIRPETQDSSFNLEEFVRIVKTDLVNNIGNFINRVFSLLEKTPYRDLNYQISPEYIEFIKKYEVSMDEFKFRDGLKICLEMSSRGNKFVQSTKPWTMIKDGLDTQEIMTEAVGICWILLNLLKPIIPKSACDMLSNLDTDNQNIFCLIGGSNINIRILNIIKLPFKNIDLKQLREFIEGKN
Protein: Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide] (P41539)
Organism: Mus musculus (Mouse)
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular location: Secreted.
Interaction partners:
- Substance-P receptor
- Substance-K receptor
- Angiotensinogen
- Tachykinin-4
- Neuromedin-K receptor
- Kininogen-1
- Neurotensin/neuromedin N
- Tachykinin-3
- Somatostatin
- VIP peptides
Sequence:
MKILVAVAVFFLVSTQLFAEEIDANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSVEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
Protein: DNA (cytosine-5)-methyltransferase CMT3 (EC 2.1.1.37) (Protein CHROMOMETHYLASE 3) (Q94F88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the CpXpG methylation (e.g. CHG cytosine) and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone H3-like 2
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
- Histone H3.1
- Histone H3-like 4
- Histone H3-like 1
- Histone H3.3
- Histone H3-like 3
- Histone H3-like 5
- Histone H3-like centromeric protein CENH3
- DNA
Sequence:
MAPKRKRPATKDDTTKSIPKPKKRAPKRAKTVKEEPVTVVEEGEKHVARFLDEPIPESEAKSTWPDRYKPIEVQPPKASSRKKTKDDEKVEIIRARCHYRRAIVDERQIYELNDDAYVQSGEGKDPFICKIIEMFEGANGKLYFTARWFYRPSDTVMKEFEILIKKKRVFFSEIQDTNELGLLEKKLNILMIPLNENTKETIPATENCDFFCDMNYFLPYDTFEAIQQETMMAISESSTISSDTDIREGAAAISEIGECSQETEGHKKATLLDLYSGCGAMSTGLCMGAQLSGLNLVTKWAVDMNAHACKSLQHNHPETNVRNMTAEDFLFLLKEWEKLCIHFSLRNSPNSEEYANLHGLNNVEDNEDVSEESENEDDGEVFTVDKIVGISFGVPKKLLKRGLYLKVRWLNYDDSHDTWEPIEGLSNCRGKIEEFVKLGYKSGILPLPGGVDVVCGGPPCQGISGHNRFRNLLDPLEDQKNKQLLVYMNIVEYLKPKFVLMENVVDMLKMAKGYLARFAVGRLLQMNYQVRNGMMAAGAYGLAQFRLRFFLWGALPSEIIPQFPLPTHDLVHRGNIVKEFQGNIVAYDEGHTVKLADKLLLKDVISDLPAVANSEKRDEITYDKDPTTPFQKFIRLRKDEASGSQSKSKSKKHVLYDHHPLNLNINDYERVCQVPKRKGANFRDFPGVIVGPGNVVKLEEGKERVKLESGKTLVPDYALTYVDGKSCKPFGRLWWDEIVPTVVTRAEPHNQVIIHPEQNRVLSIRENARLQGFPDDYKLFGPPKQKYIQVGNAVAVPVAKALGYALGTAFQGLAVGKDPLLTLPEGFAFMKPTLPSELA
Protein: Protein phosphatase 2C 50 (OsPP2C50) (EC 3.1.3.16) (ABI1-like protein 3) (OsABI-LIKE3) (OsABIL3) (Q6L5H6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Protein phosphatase involved in abscisic acid (ABA) signaling. Together with PYL3 and SAPK10, may form an ABA signaling module involved in stress response.
Interaction partners:
- Abscisic acid receptor PYL3
- Abscisic acid receptor PYL10
- Abscisic acid receptor PYL9
- Serine/threonine-protein kinase SAPK10
- Serine/threonine-protein kinase SAPK3
- Serine/threonine-protein kinase SAPK9
- Serine/threonine-protein kinase SAPK8
- Os02g0226801 protein
- Serine/threonine-protein kinase SAPK2
- Serine/threonine-protein kinase SAPK1
Sequence:
MAAAAAAAAICGEDETAARVGCTGEWAGGIERVDLGERKEAVAAAGAGKRSVYLMDCAPVWGCASTRGRSAEMEDASAAVPRFADVPVRLLASRRDLDALGLDADALRLPAHLFGVFDGHGGAEVANYCRERIHVVLSEELKRLGKNLGEMGEVDMKEHWDDVFTKCFQRVDDEVSGRVTRVVNGGGEVRSEPVTAENVGSTAVVALVCSSHVVVANCGDSRIVLCRGKEPVALSIDHKPDRKDERARIEAQGGKVIQWNGYRVSGILAMSRSIGDRYLKPFVIPKPEVMVVPRAKDDDCLILASDGLWDVVSNEEACKVARRQILLWHKNNGAASPLSDEGEGSTDPAAQAAADYLMRLALKKGSEDNITVIVVDLKPRKKLKNIS
Protein: Uncharacterized protein C20H4.08 (Q7LKV1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C2F7.02c
- Alcohol dehydrogenase 4
- Mitochondrial fission 1 protein
- Dynamin-related protein dnm1
Sequence:
MSVPIDRINTVDTLANTLESNLKFFPEKIHFNIRGKLIVIDRVELPILPTTVLALLFPNGFHLLLKHEGGDVSSCFKCHKIDPSICKWILDTYLPLFKKSNNAYPSKIAFNPISNTTLVLFLTECCNIYLFSENKKPVDQKIRSDLLEQTFKNNDVFESADKKKIRKGLSDGPLVDALQHCGFRYNDKWAKRVKEPKLMSLMSYIITTVESSSLSEEFLSKILKLWGQPGNKCWWINEVIKVNGSLINVWRRKQWLLEVTIMGNRENSQD
Protein: PHD finger protein 1 (F7ELX2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTPDSIMLLLLTISCSSRVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSKLLSALNSHKDRFISGREIKKRKCLFGLHARTPPPVELLTGDGSPTSSPIRMFASFHPSASTAGTSGDSEPPDRSPLELHIGFPTDIPKSSPHSVTASSSSVPALTPGLSRHSLPPSPLCRSLSPGTGGGVRGGVSYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
Protein: Troponin C, slow skeletal and cardiac muscles (TN-C) (P63315)
Organism: Bos taurus (Bovine)
Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Interaction partners:
- Troponin T, cardiac muscle
- Troponin I, cardiac muscle
- Troponin I, cardiac muscle
- Troponin C, skeletal muscle
- Troponin T, slow skeletal muscle
- Troponin T, fast skeletal muscle
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Tropomyosin alpha-3 chain
- Tropomyosin beta chain
- MYH3 protein
Sequence:
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLEELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Protein: Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) (P54756)
Organism: Homo sapiens (Human)
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10375373}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Interaction partners:
- Ephrin-A5
- Ephrin-A3
- Ephrin-A2
- Ephrin-A1
- Tyrosine-protein kinase ABL1
- Ephrin-B2
- Ephexin-1
- Ephrin-A4
- Ras GTPase-activating protein 1
- Ephrin type-A receptor 3
Sequence:
MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL
Protein: 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) (5'-AMP-activated protein kinase 40 kDa subunit) (P80386)
Organism: Rattus norvegicus (Rat)
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Interaction partners:
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- 5'-AMP-activated protein kinase subunit gamma-1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- Protein kinase AMP-activated non-catalytic subunit gamma 2
- Protein kinase AMP-activated non-catalytic subunit gamma 3
- 5'-AMP-activated protein kinase subunit beta-2
- Serine/threonine-protein kinase STK11
- Calcium/calmodulin-dependent protein kinase kinase 2
- Glycogen [starch] synthase, muscle
- Glycogen [starch] synthase, liver
Sequence:
MGNTSSERAALERQAGHKTPRRDSSGGTKDGDRPKILMDSPEDADIFHTEEMKAPEKEEFLAWQHDLEVNEKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
Protein: HTH-type transcriptional repressor SmtB (P9WMI5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of zinc. Could act as the metal sensor that controls the expression of zur in response to zinc availability.
Interaction partners:
- Zinc uptake regulation protein
- HTH-type transcriptional regulator CmtR
- Probable cation efflux system protein Rv2025c
Sequence:
MVTSPSTPTAAHEDVGADEVGGHQHPADRFAECPTFPAPPPREILDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALHVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVLDAVAHAGEDAI
Protein: Cyclin dependent kinase 13 (A0A2R8Y7W5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPERFLHAEAMHHSKMAESLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
Protein: HEPN domain-containing protein (Q7D3V8)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Interaction partners:
Sequence:
MKTSLDHIPPQIQTELQRALEIIHEEFEDALEGGTAKFKKRGRILKIILFGSYARGTQVDEPFTSKGYRSDFDLLVIVNNRKLTDFAEYWYKAADRLIRDKMIKRPVQIIVHSLREVNTSLQESQHFFSDIRKEGIALYELDDKPLAEPKTLTPEEQLRVAKEHFEKRFGAGRNFAALSDAALQKGMISEAAFLLHQAIEQAYASVLLTLTNYTPASHNLKVLRSFAEERDRRLIEAFPRDHHRERAWFNTINEAYVKARYSSQYKISQEALDWIGERATLLLSLVGEVCRDHISALERDAGREIAEQGAAEE
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A1P8B6S7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MVVLRKTSLLVFFLFLLLLLESTFEQQTSSLNEKSALLLLRSSLGLRSRDWPVKGNPCLNWNGIKCDQNGRVTKINISGFRRTRIGNQNPEFSVGSLVNLTRLASFNASRFYLPGPIPALFGSSLLTLEVLDLSSCSITGTIPESLTRLSHLKVLDLSKNAINGDIPLSLTSLQNLSILDLSSNSVFGSIPANIGALSKLQRLNLSRNTLTSSIPPSLGDLSVLIDLDLSFNGMSGSVPSDLKGLRNLQTLVIAGNRLSGSLPPDLFSLLSKLQIIDFRGSGFIGALPSRLWSLPELKFLDISGNHFSDMLPNTTVSFDSTVSMLNISGNMFYGNLTLLLTRFQVVDLSENYFEGKIPDFVPTRASLSNNCLQGPEKQRKLSDCTLFYSKKGLTFNNFGQHEEKKSSKTSWLSHTKIVILAAVGGSILLMLILIVLPITVSFCVRRRNRSSTSNHPRGRHNGVGPLPPDETLPSRGGVSINFGSLGSSFTYQQLLNATKEFSDSNLIKKGQSGDLFKGVLENGVQIVVKRISLESTKNNEAYLTELDFFSRFAHPRIIPFVGKSLESATHKFLVYKYMLNRDLPSSLFYKSNSLVDNGLRSLDWITRLKIALGVAEGLAYLHHDCSPSVVHRDIQASSILLDDKFEVRLGSFSKACHQENNGRPRKIARLLRLSQ
Protein: Probable leucine-rich repeat receptor-like protein kinase At5g63930 (EC 2.7.11.1) (Q9LVP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- D-aminoacyl-tRNA deacylase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Sequence:
MVKEMMKLAVFFISLLLILLISETTGLNLEGQYLLEIKSKFVDAKQNLRNWNSNDSVPCGWTGVMCSNYSSDPEVLSLNLSSMVLSGKLSPSIGGLVHLKQLDLSYNGLSGKIPKEIGNCSSLEILKLNNNQFDGEIPVEIGKLVSLENLIIYNNRISGSLPVEIGNLLSLSQLVTYSNNISGQLPRSIGNLKRLTSFRAGQNMISGSLPSEIGGCESLVMLGLAQNQLSGELPKEIGMLKKLSQVILWENEFSGFIPREISNCTSLETLALYKNQLVGPIPKELGDLQSLEFLYLYRNGLNGTIPREIGNLSYAIEIDFSENALTGEIPLELGNIEGLELLYLFENQLTGTIPVELSTLKNLSKLDLSINALTGPIPLGFQYLRGLFMLQLFQNSLSGTIPPKLGWYSDLWVLDMSDNHLSGRIPSYLCLHSNMIILNLGTNNLSGNIPTGITTCKTLVQLRLARNNLVGRFPSNLCKQVNVTAIELGQNRFRGSIPREVGNCSALQRLQLADNGFTGELPREIGMLSQLGTLNISSNKLTGEVPSEIFNCKMLQRLDMCCNNFSGTLPSEVGSLYQLELLKLSNNNLSGTIPVALGNLSRLTELQMGGNLFNGSIPRELGSLTGLQIALNLSYNKLTGEIPPELSNLVMLEFLLLNNNNLSGEIPSSFANLSSLLGYNFSYNSLTGPIPLLRNISMSSFIGNEGLCGPPLNQCIQTQPFAPSQSTGKPGGMRSSKIIAITAAVIGGVSLMLIALIVYLMRRPVRTVASSAQDGQPSEMSLDIYFPPKEGFTFQDLVAATDNFDESFVVGRGACGTVYKAVLPAGYTLAVKKLASNHEGGNNNNVDNSFRAEILTLGNIRHRNIVKLHGFCNHQGSNLLLYEYMPKGSLGEILHDPSCNLDWSKRFKIALGAAQGLAYLHHDCKPRIFHRDIKSNNILLDDKFEAHVGDFGLAKVIDMPHSKSMSAIAGSYGYIAPEYAYTMKVTEKSDIYSYGVVLLELLTGKAPVQPIDQGGDVVNWVRSYIRRDALSSGVLDARLTLEDERIVSHMLTVLKIALLCTSVSPVARPSMRQVVLMLIESERSEGEQEHLDTEELTQTTTP
Protein: F(420)H(2) dehydrogenase subunit A (EC 1.5.98.3) (F(420)H(2)-dependent phenazine dehydrogenase subunit A) (F(420)H(2)-dependent phenazine oxidoreductase subunit A) (FPO subunit A) (Methanophenazine hydrogenase subunit A) (Methanosarcina-phenazine hydrogenase subunit A) (Q8PU58)
Organism: Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Function: Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MIGDTMSGIIDSYIPVAIFLAVGLIMPPMTMFMVKQLSPRSKAASKYTTYESGSVPTGTARIQFNVEYYLYAIAFVLFDIEVLFLYPWATVYKGHGITSIAVVEMFVFIFILLFGYVYLWKKEALTWVK
Protein: Syntaxin-122 (AtSYP122) (Synt4) (Q9SVC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vesicle trafficking protein that functions in the secretory pathway.
Subcellular location: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- SNAP25 homologous protein SNAP33
- Vesicle-associated membrane protein 721
- UPF0235 protein At5g63440
- Putative syntaxin-24
- VAMP-like protein YKT62
- Syntaxin-31
- Putative SNAP25 homologous protein SNAP30
- VAMP-like protein YKT61
- Syntaxin-71
- Syntaxin-32
Sequence:
MNDLLSGSFKTSVADGSSPPHSHNIEMSKAKVSGGSCHGGNNLDTFFLDVEVVNEDLKELDRLCHNLRSSNEQSKTLHNANAVKELKKKMDADVTAALKTARRLKGNLEALDRANEVNRSLPESGPGSSSDRQRTSVVNGLRKKLKDEMEKFSRVRETITNEYKETVGRMCFTVTGEYPDEATLERLISTGESETFLQKAIQEQGRGRILDTINEIQERHDAVKDIEKSLNELHQVFLDMAVLVEHQGAQLDDIEGNVKRANSLVRSGADRLVKARFYQKNTRKWTCFAILLLLIIVVLIVVFTVKPWESNGGGGGGAPRQATPVQAQPPPPPAVNRRLLR
Protein: Oxidoreductase, putative (EC 1.6.5.5) (Q38A19)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQRKIVAKRLSSNFREATEVLSSPIPSYLKSTELLVKNRFVGINASDINFTSGKYLPGTVPPFDCGFEALGEVVAVGDGIKQFCAGDVVVTQAFGAFCEYQVVPSRSAKKVPLLKCEYLPLDLSGTTASISIGEILKPLRGELAVVTAAGGGTGQFAVQILKKVYDCTVVGVTSSCSKENMLKELGCDHVIVGERESVGEAMKQLMPTGVNVAYESVGGDMLDVVVDNISLRGRVLSIGGISGYSNGGSWDYSEKGKAPLPMRLLSKSASLNTFFLPHYIKYAKLHFSRLCQMYEQGTLQSCIDPSKFKGLEAVADAVEYMYERRNKGKVIVEI
Protein: Dual-specificity protein phosphatase SDP1 (EC 3.1.3.48) (Stress-inducible MAPK phosphatase) (P40479)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.
Interaction partners:
- Mitogen-activated protein kinase SLT2/MPK1
- Transcription factor RLM1
- Tyrosine-protein phosphatase MSG5
- Dual specificity protein phosphatase PPS1
- Serine/threonine-protein kinase KDX1
- Mitogen-activated protein kinase FUS3
- Mitogen-activated protein kinase KSS1
- DNA polymerase delta catalytic subunit
Sequence:
MNIYTSPTRTPNIAPKSGQRPSLPMLATDERSTDKESPNEDREFVPCSSLDVRRIYPKGPLLVLPEKIYLYSEPTVKELLPFDVVINVAEEANDLRMQVPAVEYHHYRWEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAKTNVQANSYRKVP
Protein: TGACG motif-binding factor 6 (F4J8P7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADTSSRTDVSTDGDTDHRDLGFYYLYNVTPGRLVPESLGKTWGILPSDRGHMHAAASDSSDRSKDKLDQKTLRRLAQNREAARKSRLRKKAYVQQLENSRLKLTQLEQELQRARQQGVFISSSGDQAHSTGGNGALAFDAEHSRWLEEKNRQMNELRSALNAHAGDTELRIIVDGVMAHYEELFRIKSNAAKNDVFHLLSGMWKTPAERCFLWLGGFRSSELLKLLANQLEPMTERQVMGINSLQQTSQQAEDALSQGMESLQQSLADTLSSGTLGSSSSDNVASYMGQMAMAMGQLGTLEGFIRQADNLRLQTLQQMLRVLTTRQSARALLAIHDYSSRLRALSSLWLARPRE