wanglab/gogpt-training-data huggingface dataset:
Protein: YTH domain-containing family protein (Q1JPL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Proline transporter 2
Sequence:
MYTEGASDFVIDQSMYYPAYYSSGYDSSVGLQGGQNENAPYICYTPSYGYAQSPYNPYNPYIPGASIGVDSSFVGFQQYYSDPPYESAASSPTYVPYVIQPDMVSNSSTDSLVANGGQSDGRGSMQRNGSAIAGLPKDAPKSTTTGQYKQPGIPKNVSTTASAHSLQGKTAYANTLLPYGKSDIANGVSSIASYSYKPCSKIYDARGDNNTTGSTYTSEQNRGSRTRRSRNQLIVKAYTTKAGNADAEGNIVINPDRYNKEDFSIEYSDARFFVIKSYSEDDVHKSIKYGVWSSTLNGNKKLQSVYEDAQRIATEKSRECPIFLFFSVNSSGLFCGVAEMTGPVSFDRDMDFWQQDKWSGSFPVKWHIIKDVPNSYFRHIILHNNENKPVTNSRDTQEIILKQGLEVLKLFKHHAEKTSLLDDFMYYEDRQRLMQEERARLPFRTFRRPFPVLNLDFSDRSKKSSKDVVKKPSVTSAETKVVQLKNSDGDEKSNTQEATDDSTPSTLKFGSLAIKPTAGTTFNPTQPKPKPTPSLGSDHKSDSSEEVTGSLADDIVSVGSLPIKVKGSKELSSKIAAVGTSPLSTQDQFRSKPGF
Protein: Bombesin receptor subtype-3 (BRS-3) (Q8K418)
Organism: Rattus norvegicus (Rat)
Function: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Neuromedin B
- Gastrin-releasing peptide
- Gastrin-releasing peptide receptor
Sequence:
MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCFKAEQPEPPLGDTPLNNLTVMGRVPATGSAHVSEISVTLFSGSTAKKGEDKV
Protein: DNA polymerase catalytic subunit (EC 2.7.7.7) (P03198)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Replicates viral genomic DNA in the late phase of lytic infection, producing long concatemeric DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein.
Subcellular location: Host nucleus {ECO:0000269|PubMed:15731235}. Note=the protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Interaction partners:
Sequence:
MSGGLFYNPFLRPNKGLLKKPDKEYLRLIPKCFQTPGAAGVVDVRGPQPPLCFYQDSLTVVGGDEDGKGMWWRQRAQEGTARPEADTHGSPLDFHVYDILETVYTHEKCAVIPSDKQGYVVPCGIVIKLLGRRKADGASVCVNVFGQQAYFYASAPQGLDVEFAVLSALKASTFDRRTPCRVSVEKVTRRSIMGYGNHAGDYHKITLSHPNSVCHVATWLQDKHGCRIFEANVDATRRFVLDNDFVTFGWYSCRRAIPRLQHRDSYAELEYDCEVGDLSVRREDSSWPSYQALAFDIECLGEEGFPTATNEADLILQISCVLWSTGEEAGRYRRILLTLGTCEDIEGVEVYEFPSELDMLYAFFQLIRDLSVEIVTGYNVANFDWPYILDRARHIYSINPASLGKIRAGGVCEVRRPHDAGKGFLRANTKVRITGLIPIDMYAVCRDKLSLSDYKLDTVARHLLGAKKEDVHYKEIPRLFAAGPEGRRRLGMYCVQDSALVMDLLNHFVIHVEVAEIAKIAHIPCRRVLDDGQQIRVFSCLLAAAQKENFILPMPSASDRDGYQGATVIQPLSGFYNSPVLVVDFASLYPSIIQAHNLCYSTMITPGEEHRLAGLRPGEDYESFRLTGGVYHFVKKHVHESFLASLLTSWLAKRKAIKKLLAACEDPRQRTILDKQQLAIKCTCNAVYGFTGVANGLFPCLSIAETVTLQGRTMLERAKAFVEALSPANLQALAPSPDAWAPLNPEGQLRVIYGDTDSLFIECRGFSESETLRFADALAAHTTRSLFVAPISLEAEKTFSCLMLITKKRYVGVLTDGKTLMKGVELVRKTACKFVQTRCRRVLDLVLADARVKEAASLLSHRPFQESFTQGLPVGFLPVIDILNQAYTDLREGRVPMGELCFSTELSRKLSAYKSTQMPHLAVYQKFVERNEELPQIHDRIQYVFVEPKGGVKGARKTEMAEDPAYAERHGVPVAVDHYFDKLLQGAANILQCLFDNNSGAALSVLQNFTARPPF
Protein: Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) (P17153)
Organism: Gallus gallus (Chicken)
Function: Collagen-binding protein.
Interaction partners:
- Caspase-3
- Actin, cytoplasmic 1
- Apoptosis regulator Bcl-2
- Caspase 9
- Cholecystokinin
- Collagen alpha-1
- Uncharacterized protein
- Caspase-8
- Glyceraldehyde-3-phosphate dehydrogenase
- Uncharacterized protein.
Sequence:
MAKYTRGTVTAFSPFDARADAEALRKAMKGMGTDEETILKILTSRNNAQRQEIASAFKTLFGRDLVDDLKSELTGKFETLMVSLMRPARIFDAHALKHAIKGAGTNEKVLTEILASRTPAEVQNIKQVYMQEYEANLEDKITGETSGHFQRLLVVLLQANRDPDGRVDEALVEKDAQVLFRAGELKWGTDEETFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKLLLAVVKCIRSVPAYFAETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKSLYQMIQKDTSGDYRKALLLLCGGDDE
Protein: AT4g39960/T5J17_130 (Molecular chaperone Hsp40/DnaJ family protein) (Q940V1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock protein DnaJ with tetratricopeptide repeat-containing protein
- Heat shock 70 kDa protein 7, chloroplastic
- Heat shock protein DnaJ with tetratricopeptide repeat-containing protein
- Heat shock 70 kDa protein 6, chloroplastic
- Heat shock protein 90-3
- Heat shock protein 90-4
- Protein CHLOROPLAST J-LIKE DOMAIN 1
- Chaperone DnaJ-domain superfamily protein
- SufE-like protein 1, chloroplastic/mitochondrial
- RBR-type E3 ubiquitin transferase
Sequence:
MALIQFGSSCVAQWGILRPRFAVKAFYPSRLESHQDNCISQINCLGASRSSMFAQGSLPFLSLTGVSPNTHSRRGARFTVRADTDFYSVLGVSKNATKAEIKSAYRKLARSYHPDVNKDAGAEDKFKEISNAYEILSDDEKRSLYDRYGEAGVKGAGMGGMGDYSNPFDLFESLFEGMGGMGGMGGGMGSRGSRSRAIDGEDEYYSLILNFKEAVFGIEKEIEISRLESCGTCNGSGAKAGTKPTKCKTCGGQGQVVASTRTPLGVFQQVMTCSPCNGTGEISKPCGACSGDGRVRRTKRISLKVPAGVDSGSRLRVRGEGNAGKRGGSPGDLFAVIEVIPDPVLKRDDTNILYTCKISYVDAILGTTLKVPTVDGEVDLKVPAGTQPSTTLVMAKKGVPVLNKSKMRGDQLVRVQVEIPKRLSKEEKMLVEELADMSKNKVANSRR
Protein: SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) (A2AAY5)
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Subcellular location: Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Interaction partners:
- Hematopoietic lineage cell-specific protein
- Src substrate cortactin
- NADPH oxidase 1
- Actin nucleation-promoting factor WAS
- NADPH oxidase 3
- NADPH oxidase activator 1
- Disintegrin and metalloproteinase domain-containing protein 15
- Matrix metalloproteinase-14
Sequence:
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
Protein: Protein FREE1 (FYVE domain protein required for endosomal sorting 1) (FYVE domain-containing protein 1) (Q9ASS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth. Required for the formation of intra-luminal vesicles (ILVs)in MVBs. Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin. Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain. Regulates ubiquitin-dependent membrane protein degradation, vacuolar transport, autophagy, and vacuole biogenesis. ESCRT component that binds ubiquitin and regulates vacuolar sorting of proteins. Attenuates abscisic acid (ABA) signaling through RSL1-triggered degradation of the ABA receptors PYR1 and PYL4. Interacts with PYL4 and PYR1, and delivers the ubiquitinated ABA receptors as cargo to the vacuolar degradation pathway. In response to ABA, is phosphorylated by SnRK2 kinases which mediate FREE1 nuclear import. In the nucleus, interacts with the ABA-responsive transcription factors ABF4 and ABI5 to reduce their ability to bind to their cis-regulatory sequences of downstream genes, thus leading to transcriptional inhibition of ABA signaling pathway. Negatively regulates salt stress tolerance via a negative feedback loop involving ABA signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24843126, ECO:0000269|PubMed:25438943, ECO:0000269|PubMed:25699591, ECO:0000269|PubMed:30962512}. Prevacuolar compartment membrane {ECO:0000269|PubMed:25438943, ECO:0000269|PubMed:27495812}; Peripheral membrane protein {ECO:0000269|PubMed:25438943}. Late endosome {ECO:0000269|PubMed:24843126, ECO:0000269|PubMed:25699591, ECO:0000269|PubMed:27495812}. Endosome, multivesicular body {ECO:0000269|PubMed:32786047}. Nucleus {ECO:0000269|PubMed:24843126, ECO:0000269|PubMed:30962512}. Note=In response to abscisic acid (ABA), SnRK2 kinases phosphorylate FREE1, a step requisite for ABA-induced FREE1 nuclear import. {ECO:0000269|PubMed:30962512}.
Interaction partners:
- SH3 domain-containing protein 2
- Protein ELC
- Protein ELC-like
- Vacuolar protein sorting-associated protein 2 homolog 1
- Calcium uptake protein, mitochondrial
- Vacuolar protein sorting-associated protein 36
- Vacuolar protein sorting-associated protein 28 homolog 2
- Vacuolar protein-sorting-associated protein 37 homolog 1
- Vacuolar protein sorting-associated protein 25
- ESCRT-related protein CHMP1B
Sequence:
MQQGDYNSYYHHQYSQFQNPTPNPNPNPNPSPPAPATVAGPTDLTRNTYASAPPFTGGYGSADYSNYSQNYTPYGQNSEHVPPSAPSFTSPSQPPPSPPATSLNPNSYSTFNQPPPPPTIHPQPLSSYGSFDSTAPYQQPTSQHMYYSPYDQHQTSGYSSAPPPSSAPAPNPNPAPYSSSLYSAPPYSSGGSSIPPSYEKPSVKFDQSGYDGYNRSRSDLGSDLYGKRSDSGEYPAFEDSYGDGVYAYQGGKVEPYGSRGTAPKSSNSTLFDDYGRSISFSSSGRDSSVSSNSAKIVRAVPKADVQEDSTGGVQKFRVKLLAETYGQTTTDVLCQIGLDGLRMLDPSTSRTLRIYPLENITRCEKLDSSILAFWSKTPVDIEAKRIRLQSNSYTTNTLLDTVTAAMFQAKEIGGSSRPPTSGKLIEQTAEKKKGLGDWMNIIKPVNEEKDHWVPDEAVSKCTSCGSDFGAFIRRHHCRNCGDVFCDKCTQGRIALTAEDNAPQVRVCDRCMAEVSQRLSNAKETTGRNVSLQSHEDLARKLQEEMERNRKSSSGLREGSGRRMKEVACPTCTVHLQVQVPVSGSETIECGVCQNPFLVSAH
Protein: Ash2-like, histone lysine methyltransferase complex subunit (Set1/Ash2 histone methyltransferase complex subunit ASH2) (F1RAW8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Retinoblastoma-binding protein 5.
- WD repeat domain 5
- Protein dpy-30 homolog
- WD repeat-containing protein 82
- CXXC finger protein 1b.
- Histone-lysine N-methyltransferase
- CXXC finger protein 1a.
- Histone-lysine N-methyltransferase SETD1B-A
- Multiple endocrine neoplasia I.
- Nuclear receptor coactivator 6
Sequence:
MAAEARSVTERDTADGDASFGDLTTNMETESSSGKETMDTAGDSSEAADAQTGSGDDENGRQLGEVELQCALCMKWFTADTFSIDTATCLPFMTNYVFHCNVCHHSGNTYFLRKQANLKEMCLTALANLTWRSRTQEEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKLTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLGNIGPSYDNQKQMTTVTGAGGLNGGSTFSGGLPSAATGKGRGAKRKQQQQQDGAATGAAKRTRSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVTGEKGYSMVRASHGVRKGSWFFEVTVDEMPQDAAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTRFHQSIGKHYSDGYGLGDILGFFIELPDETETAKALPDTYKDKALIKFKSYLYFEEKDYVDKAEKNLKPTSTSRMIFFKNGVNQGVAYEDLFEGMYYPAISLYKGCTVSVNFGPHFKYPPKDIKFQPMSDMGWGAVIEHTLADMLYHVETEVDGRRSPQYEG
Protein: Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1) (Q5XJ87)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03201}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03201}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Elongation of very long chain fatty acids protein 1
- Very-long-chain 3-oxoacyl-CoA reductase-A
- Very-long-chain 3-oxoacyl-CoA reductase-B
- 20beta-hydroxysteroid dehydrogenase type 2
Sequence:
MFQEVLSNILRFHDYLLKRTDARVRDYPLMQSPILMTFILLGYVFSVLYVGPRYMASRKPFRLNTAMIAYNFFMVAFNAYTVYEFLMSGWATTYTWRCDLCDPSSSPQALRMVRAAWLFYFSKYIELLDTVFFVLRKKHSQVTFLHIFHHSVLPWTWWWGITLTPAGGMGSFHALVNACVHVIMYTYYGLAAAGPRFQKYLWWKKYMTAIQLIQFVLVTGHISQYYFMEKCDYQVPIFIHLILIYGTFFFILFSNFWIQAYIKGKRLPVSNEDKPKRNGVITVIDPVVVANGKHLENGNAHYSNGFAHNGKVKEV
Protein: U1 small nuclear ribonucleoprotein usp102 (U1 snRNP protein usp102) (O74968)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nuclear mRNA splicing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U1 small nuclear ribonucleoprotein C
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 snRNP-associated protein usp108
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D1
- U1 snRNP-associated protein usp107
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein G
- U1 snRNP-associated protein usp106
Sequence:
MDPQTNSHQEVQQPSPKETDSQTPSETLYIRNIEEKIRLTMLKRILEHLFGSYGKVIDVQARKTLRMRGQAFVVFDNLENASRALKDLQGYPLYGKPMMIQYSKSKSDIIVQRESPEEIETRKKDRKNRREMLKRTSALQPAAPKPTHKKPVPKRNVGAERKSTINEDLLPPNKVLLLQNIPQEVNADVLTQIFEAFSGFQEVRMVPGRRGIAFVEYDSDREATVAKNGTTGMSLSGNQIKVTFARKAS
Protein: Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) (Q9BRK4)
Organism: Homo sapiens (Human)
Function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Interaction partners:
- Katanin p80 WD40 repeat-containing subunit B1
- Signal-induced proliferation-associated 1-like protein 1
- Leucine zipper putative tumor suppressor 1
- Katanin p60 ATPase-containing subunit A1
- SH3 and multiple ankyrin repeat domains protein 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Sequence:
MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI
Protein: histidine kinase (EC 2.7.13.3) (Q1D1W0)
Organism: Myxococcus xanthus (strain DK1622)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- DNA-binding response regulator
- DNA-binding response regulator PhoP2
- DNA-binding response regulator
- DNA-binding heavy metal response regulator
- Response regulator
- DNA-binding response regulator
- Response regulator
- histidine kinase
- histidine kinase
- DNA-binding response regulator
Sequence:
MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDPAGAPRIEPSSALRAYQARRPQLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAPTLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFPIHGIGTAVVVTSGNRLGLDDLPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPDGVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRDLRRDATRLGLMVDQLLAAFRMQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEAASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRMEASTSSVTVDVVDHGPGVEESDRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGRSIDPSACCKD
Protein: Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) (Q96PE3)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:15716355}. Recycling endosome membrane {ECO:0000269|PubMed:15716355}. Cell membrane {ECO:0000269|PubMed:15716355}. Nucleus {ECO:0000269|PubMed:30071275}. Cytoplasm {ECO:0000269|PubMed:30071275}. Postsynaptic density {ECO:0000250|UniProtKB:Q9EPW0}. Note=Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275). {ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:30071275}.
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Inositol polyphosphate 5-phosphatase OCRL
- Synaptojanin-1
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol 3-kinase regulatory subunit beta
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Synaptojanin-2
Sequence:
MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
Protein: Transcriptional regulator QRICH1 (Glutamine-rich protein 1) (Q2TAL8)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth.
Subcellular location: Nucleus {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}. Cytoplasm {ECO:0000269|PubMed:30281152}. Cell membrane {ECO:0000269|PubMed:30281152}.
Interaction partners:
- Bifunctional epoxide hydrolase 2
- GMP synthase
- Glutamine-rich protein 2
- Bifunctional purine biosynthesis protein ATIC
Sequence:
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANASTMH
Protein: Neurexin-3-beta (A7UQ09)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRQKFDDTGQYLTIWLVFTVSLFSVVDSIILTGAPDSYARYPKWAHSFENSLSMELKTRQSDGMLLYTDDGGTHGNFYSLTIVEGHIQLDFRLGDNSNEFGQRRPVNTIRIEEVRIDDDKWHTLTIFQSWENVKLELDYTLVFKILNQRSFVFGNILKNSDVFIGGLPPNMHMLPVMSSPLRRYARHLAVNVRNLMYRQYPQGVTSPQLLESVGTRTNEDDHCKSKSMSSREQFVCLNDGECYSSNDGPHCDCQFSDHDGRNCEIEKNDGELTFGGDEWVGYDVSLNISAAVRAKKENLTLTFKTVHGTSMLFYAGDEKSYLHVMLQDGAIIASSKFDGSDARIIRMFNSFPSQRYDDDSWHTIILERSLQMMTLIVDGRRDEIRQYAPELDWISNSFGFLGSIPKHNPSKEVNRVSFRGCMKKVRYDIDATRILLVNLADQSYGGSVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQHNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVEHIKIRFRTTSSRGVLFDTGANGKNDKITVFLNDSQLNLFLQDSSTNNTFSWGKSLSDNHWHELQVRRLGQKLLLYLDGFWSHSIYLQNPISVEIDEVGAAFSVHSSAPPPRDEHFKGFLSKLVFNGNDYLAKTKMNSAQLSKSSSRESKGQRNVKTRIASISFTNSTGYVAFSSDKISGLTGSFRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYRTSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVESKMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQDYFTIFLNKGYLNAHYNLGNRDHTTSYHTRILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMILDLYENGSNRIHTIGAPQTTAVSEQVSSESEEDDELAEMMMAHSIDENPNEALIESLAPSCLSLEEQQSCFIDTDDSTGFFSPVLPTVANFPTTRQTEPETTRRPLSPSKMTPSLPSPTTTTLPVFFLSQITDGDESEDEFDGSGDDLFGGDGVGITAATQPSVKRTTSISVVTKVLTTTSEPSSTHRSTVLPRPYASVKEAAEQNPDYLGASIWNQVDTLPEPMVTGPAWRTNKSLTTTATTEASSTKSNRKTTTTTTTSATTTIRIQQRPNYDIDNEVTALITSSLAPQKTRPKSTPHFTVYPVRPTTPMGDTITTTMQAATVTDFPRTPLIMCSSLAVIIAIAAVVFFVFKCRQNPPNSEHYTMAMKSQSGYTAIAPELSPPMNHDRSNDSCTQPLLAKPHINGNGYEPLKGAVIANGNGATATMMRNGNGNGVAKKKDFKEWYV
Protein: GH14445p (Histamine-gated chloride channel alpha21 subunit) (Histamine-gated chloride channel subunit 1, isoform C) (Q95T69)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQSPTSKLVEFRCLIALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESCRWKCNGYLHPANPVSLGTFHSASRITNNLC