wanglab/gogpt-training-data huggingface dataset:
Protein: Arylsulfatase G (ASG) (EC 3.1.6.1) (N-sulfoglucosamine-3-sulfatase) (EC 3.1.6.15) (Q96EG1)
Organism: Homo sapiens (Human)
Function: Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Subcellular location: Lysosome {ECO:0000269|PubMed:12461688, ECO:0000269|PubMed:18283100}. Note=The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. {ECO:0000250|UniProtKB:Q3TYD4}.
Interaction partners:
- Arylsulfatase B
- Arylsulfatase A
- Arylsulfatase K
- Formylglycine-generating enzyme
Sequence:
MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA
Protein: Small ribosomal subunit protein mS29 (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (P82922)
Organism: Bos taurus (Bovine)
Function: Involved in mediating interferon-gamma-induced cell death.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS9m
Sequence:
MLKGMTRLVSRVHKLDPGRFSHLGTQAPQCPVAHLDNQVPTERTRAISRTLENDPAKHGEQHVGQHYNISIQELKTVFPHGLPPRFVMQVKTFNEACLMVRKPALELLHYLKNTNFAHPAVRYVLYGEKGTGKTLSLCHIIHFCAKQDWLILHIPDAHLWVKNCRDLLQSTYNKQRFDQPLEASIWLKNFKTANERFLSQIKVQDKYVWNKRESTEKGSPLAEVVEQGIMRVRNATDAVGIVLKELKRQSSLGVFRLLVAVDGVNALWGRTTLKREDKSPITPEELALIYNLRKMVKNDWQGGAIVLTVSQTGSLFKPRKAYLPQELLGKEGFDTLDPFIPILVSNYNPKEFEGCIQYYLENNWLQHEKAHTEEGKKELLFLSNRNPGLLERLCAYL
Protein: Elongator complex protein 2 (O94533)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Elongator complex protein 3
- Elongator complex protein 1
- Elongator complex protein 5
- Elongator complex protein 4
- Elongator complex protein 6 homolog
- Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17c
- Protein kti12
- Cytoplasmic tRNA 2-thiolation protein 1
- tRNA
- Small ribosomal subunit protein eS24B
Sequence:
MFQYEALHVGCNRIPTAATWSSNLGLIYGAERLIAVADPFKEINYLMAGHSGRINCVCELATNSEYRSPFILSGASDKTLRLWQLEEEYFTCIKTIELEATVNCLCVNENLVVCGCSNSSCIVYSWNAEQRNLTEISRFTCSEIIPLEFAIVKLDHGIILTVCGSSKKIMVYGSDSAISSFKLKAVLRGHLDWVRTLSFKKTSGSTATLASGSQDRYIRLWNISLWGSEDEKVSEEFFESVLSNKPVRFTLGKIDLKIVFDALLMGHEDWVMSVDWHPTKEMILSSSADSSMIVWEPDTNTGIWVVTGRMGEMASSHGSTTATGSAGGFWGGLWNPNGNCVVCWGRTGGWRLWKQDAGQWLQLPSISGHTKSVKGVAWDPEGKFYLSAGTDQTTRLFARFKKDNAWHEMARPQIHGYDLTSISCMPSRIGFLSCADEKVSRVFKFPKTIVRLLYRLCDTNIGEESLPDAANVPLLGLSNKATTASETGTVNAEEVQTPVADVIGSLNHPPFEEHLQRLLLFPEVEKLFGHGYEVYACAISNNGNIAATSCKSQTPEHAVIRLYETQSWNQQQVLKGHSLTVTTIKFSPDDRYILSAGRDRLVCLHEQAENLLDYNNFASIKAHSRIIWDASWAPKEMGYFFATASRDKFVKFWKINDNKKICDVAALQFSDAVTAVDFAPFFHNDELLLAVGTEAGKIFIWRCPRENLTKWYPTRLPDHMAPMESINQILWKPTFETMGLYSLLIAGEDTSVRLLNVTLG
Protein: NAC domain-containing protein 2 (ONAC002) (OsNAC19) (Protein STRESS-RESPONSIVE NAC 1) (Q75HE5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that possesses transactivation activity. Transcription activator involved in response to abiotic stresses. Plays a positive role during dehydration and salt stress. Binds specifically to the 5'-CATGTG-3' motif found in promoters of stress-responsive genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:16924117}.
Interaction partners:
Sequence:
MGMGMRRERDAEAELNLPPGFRFHPTDDELVEHYLCRKAAGQRLPVPIIAEVDLYKFDPWDLPERALFGAREWYFFTPRDRKYPNGSRPNRAAGNGYWKATGADKPVAPRGRTLGIKKALVFYAGKAPRGVKTDWIMHEYRLADAGRAAAGAKKGSLRLDDWVLCRLYNKKNEWEKMQQGKEVKEEASDMVTSQSHSHTHSWGETRTPESEIVDNDPFPELDSFPAFQPAPPPATAMMVPKKESMDDATAAAAAAATIPRNNSSLFVDLSYDDIQGMYSGLDMLPPGDDFYSSLFASPRVKGTTPRAGAGMGMVPF
Protein: 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) (Q96P11)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA. m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity. Required for corpus callosum and cerebral cortex development (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:31722427}.
Interaction partners:
- tRNA
- 5-cytosine rRNA methyltransferase NSUN4
- tRNA
- Nucleolar complex protein 4 homolog
- E3 ubiquitin-protein ligase TRIM50
- 18S rRNA
- tRNA
- rRNA 2'-O-methyltransferase fibrillarin
- WD repeat-containing protein 74
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Sequence:
MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLDDLRALKGKHFLLDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVHYILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSTCSLCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTFPGAEHCLRASPETTLSSGFFVAVIERVEVPR
Protein: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase) (Q9DBB8)
Organism: Mus musculus (Mouse)
Interaction partners:
- Aldo-keto reductase family 1 member B7
- Aldose reductase-related protein 2
- aldose reductase
- Aldo-keto reductase family 1 member B1
- Epoxide hydrolase 1
Sequence:
MALRWGIVSAGLIANDFTTVLSSLPSSEHQVVAVAARDLNRAEEFAQKFNIPKAYGSYEELAKDPNVEVAYIATQHPQHKPAVLLCLAAGKAVLCEKPMGVNAAEVREMVAKARSQGVFLMEAIWSRFFPAMEALREVLVQGTIGDLRVARAEFGFDLSHIPRATDWNQAGGGLLDLGIYCVQFLSMIFGAQKPEKISAVGRIHETGVDDTVSVLLQYPGGVHGSFTCSISSNLPNTAYVSGTKGMAQIQKLWAPTELVVNGERKEFPPPVLGKDYNFVNGSCMLYEANHVRECLRKGLKESPVVPLAESELLAEILEEARKAIGVTFPQDKR
Protein: CBL-interacting serine/threonine-protein kinase 16 (EC 2.7.11.1) (SNF1-related kinase 3.18) (SOS2-like protein kinase PKS15) (Q9SEZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1.
Interaction partners:
- Calcineurin B-like protein 9
- Calcineurin B-like protein 1
- Potassium channel AKT1
- Dolichol-phosphate mannose synthase subunit 2
- Dolichol-phosphate mannose synthase subunit 3
- SNF1-related protein kinase regulatory subunit gamma-like PV42a
Sequence:
MEESNRSSTVLFDKYNIGRLLGTGNFAKVYHGTEISTGDDVAIKVIKKDHVFKRRGMMEQIEREIAVMRLLRHPNVVELREVMATKKKIFFVMEYVNGGELFEMIDRDGKLPEDLARKYFQQLISAVDFCHSRGVFHRDIKPENLLLDGEGDLKVTDFGLSALMMPEGLGGRRGSSDDLLHTRCGTPAYVAPEVLRNKGYDGAMADIWSCGIVLYALLAGFLPFIDENVMTLYTKIFKAECEFPPWFSLESKELLSRLLVPDPEQRISMSEIKMIPWFRKNFTPSVAFSIDETIPSPPEPPTKKKKKDLNEKEDDGASPRSFNAFQFITSMSSGFDLSNLFEIKRKPKRMFTSKFPAKSVKERLETAAREMDMRVKHVKDCKMKLQRRTEGRKGRLSVTAEVFEVAPEVSVVEFCKTSGDTLEYYLFCEDDVRPALKDIVWSWQGDDDEDDVTTNDNVDTNDNKINNVS
Protein: Metallophosphoesterase 1 (Post-GPI attachment to proteins factor 5) (A0A0A0MR93)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004457}. Golgi apparatus, cis-Golgi network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004257}.
Interaction partners:
Sequence:
MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR
Protein: 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (P63104)
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
Interaction partners:
- RAF proto-oncogene serine/threonine-protein kinase
- M-phase inducer phosphatase 3
- Serine/threonine-protein kinase B-raf
- 14-3-3 protein epsilon
- Forkhead box protein O3
- Serine/threonine-protein kinase A-Raf
- Catenin beta-1
- M-phase inducer phosphatase 2
- Protein chibby homolog 1
- 14-3-3 protein beta/alpha
Sequence:
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Protein: Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) (O08875)
Organism: Rattus norvegicus (Rat)
Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).
Interaction partners:
- Neuronal migration protein doublecortin
- Transient receptor potential cation channel, subfamily M, member 5
- Tubulin alpha-1B chain
- Tubulin alpha-1A chain
- Tubulin beta-3 chain
- Tubulin alpha-3 chain
- Tubulin alpha-8 chain
- Tubulin alpha-4A chain
- Tubulin alpha-1C chain
- Tubulin alpha chain
Sequence:
MLELIEVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRISQHGGSSTSLSSTKVCSSMDENDGPGEEESDEGFQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPSSTAAGVSVIATTALDKERQVFRRRRNQDVRGRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
Protein: At1g03030 (P-loop containing nucleoside triphosphate hydrolases superfamily protein) (Q500U9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEVSSFSTVPRYCNSRSFVPELSRFRGFKVHLWDQSLVPLHFSIRKRKNTPRYLISCSQKKDVTVVDGSCMDEIYDKLAERLVPTAAAMFSPNLKRLVGLAGPPGAGKSTVANEVVRRVNKLWPQKAASFDAEVNPPDVAIVLPMDGFHLYRSQLDAMEDPKEAHARRGAPWTFDPALLLNCLKKLKNEGSVYVPSFDHGVGDPVEDDIFVSLQHKVVIVEGNYILLEEGSWKDISDMFDEKWFIDVNLDTAMQRVENRHISTGKPPDVAKWRVDYNDRPNAELIIKSKTNADLLIRSMNI
Protein: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (Oxidase-like protein) (Q9LJ65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 2-oxoglutarate
- Thymidylate kinase
Sequence:
MEDLDPTYIQAPEHRSDSNFIPNQPEEIPVIDLSRLDDPEDVQNVISEIGDACEKWGFFQVLNHGVPSDARQRVEKTVKMFFDLPMEEKIKVKRDDVNPVGYHDGEHTKNVKDWKEVFDIYFKDPMVIPSTTDPEDEGLRLVYNKWPQSPSDFREACEVYARHAEKLAFKLLELISLSLGLPKERFHDYFKEQMSFFRINRYPPCPRPDLALGVGHHKDADVISLLAQDDVGGLQVSRRSDGVWFPIRPVPNALVINIGNCMEIWTNDKYWSAEHRVVVNTTRERYSIPFFLLPSHDVEVKPLEELVSPENPPKYKGYKWGKFYVSRNRSDFRKLEIENIQIDDFKVKT
Protein: Brother of CDO (Protein BOC) (Q9BWV1)
Organism: Homo sapiens (Human)
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12634428}; Single-pass type I membrane protein {ECO:0000269|PubMed:12634428}. Note=Enriched at sites of cell-cell contact.
Interaction partners:
- Desert hedgehog protein
- Indian hedgehog protein
- Sonic hedgehog protein
- Protein patched homolog 1
- Growth arrest-specific protein 1
- Protein patched homolog 2
- Protein smoothened
- Cell adhesion molecule-related/down-regulated by oncogenes
- Low-density lipoprotein receptor-related protein 2
- Cadherin-15
Sequence:
MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQRQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWCPQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI
Protein: Two-component system protein B (EC 2.7.13.3) (Protein NHK1) (SLN1 homolog) (Q9P4U6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Nonessential protein which may be part of a two-component regulatory system activated by changes in the extracellular environment.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Histidine-containing phosphotransfer protein
- Mitogen-activated protein kinase hog1
- Mitogen-activated protein kinase mpkC
- MAP kinase kinase kinase
- High osmolarity signaling protein sho1
Sequence:
MRVPIAVQLGLLVLLTALAGLAALAIATWINNYNFVVDVKSQSLQLVASIKSSQITSNLDLLETTSKTIITRILIQSALQRYYAGNTTEENFASSITDVQSALGSRGYLSLYQASIYARNVENGESKARRLLNVTSDEVPEIRLPYDHPNGTAVMLGDEGLGYPPSLYPNLTEDATTNKLYAFDGVPITTNQPLLLGPLATNDSFSLISLSLPIINNTSAADILGYITVVASAANLQDAMSSRQGLGSSGQVLLLAPSRPENRFPTGSRPATATSEPQIAGLDNQEVRYVFRPTPLPGNKRRHSPAVASGASFPLRDYPIALKVLNQPYDSINHSITDLSSKNENGTRVAVGAIQQRSDLVEWVLIIEETHGEAFAPVSRLRKIILACVFGTAGVIALLIPPLAHLSVAPIRRLREATRKSVNPTIGPLSPSLSTMVDPIEISMHNGNEKSEKGGFFNRLKRGRGNLATGHDRDNEPHQFQIPGRVKERKHIITDELTDLTKTFNEMSDELVIQYNRLEERVAERTRELEKAKIAAETANESKTLFIANISHELKTPLNGILGMCAVCMGEDDLPRIKRSLQTVYKSGDLLLHLLNDLLTFSRNQIDQAIRLEEKEFKLSDIRSQLQIIFQNQVQEKQISFSIKFCHPDTPPINDTPEVISRAPGPVYGPPGTAKLKDMVLWGDQHRILQILINLVGNSLKFTPEQGTVAIRIKCVGEEKNPSASPRPESRALSRWRSIGSSHASSRPKTSLDRPRDGGDEETTRPPNLRTLILQFEVEDTGPGIPQHLQNRVFEPFVQGDLRLNRKYGGTGLGLSICSQLARLMRGQIQLNSEQGRGTLFLVRIPLGFVKESPPSTASSMTSLAGSRTSSVFSLDDLASVTKAPSNHSVASQHESTKSNAEIQDSQPRLVGLSQPFFAPPVPQAKDNGLKKIRALVAEDNVVNQEVVLRMLALEDVYDVTVVKDGQEAYDTVKANMEEGKVFDLIFMDIQMPNLDGIESTRLIRQMGCSAPIVALSAFSEDSNIKDCMNSGMDMFISKPIRRPALKQVLRRFTPIPEEAEKPQM
Protein: Cilia- and flagella-associated protein 61 (CFAP61) (Flagellar-associated protein 61) (Q23F13)
Organism: Tetrahymena thermophila (strain SB210)
Function: As component of a spoke-associated complex, regulates ciliary mobility by mediating a stable and functional assembly of the radial spoke 3 (RS3).
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:25694453}.
Interaction partners:
- Cilia- and flagella-associated protein 251
- FHA domain protein
- Response regulator receiver domain protein
- CCT motif protein
- CCT motif protein
- Glutathionylspermidine synthase
- Glutathionylspermidine synthase
- Glutathionylspermidine synthase
- CCT motif protein
Sequence:
MYSNNQLDNPNHSRSQYRNGDQSGIYAGSDEEFQVLVRKSDLDDVDEVLKIIAQHEREANDLLYDYPNLLSLFEKNYLSVTILNQQQQIIGAAVFNDFPQGLTGQIDFQHENFWENWIFDAFNFDESICITPFNTLWMTFFFVAKDQYKFSQEEELIICQKVFQNVYATLPQLEGILFLKRGETMEDNGAQAQISSILENIFIEVPVKDRDIIKRVRGIHLNSEVFYSPKHACQEIIEIRMAREQDHDDLAEIFNRQSEVLTAQFGEFFIADLIATQNLTRRGTRKFLNNGKAIVGQVRDKAVGLMSISTDIDYKFLAQCFELETYDNLFKPDFMEAIQNKRDDIRRENQYREEDQYQEIVKKMNEERMKSHFIGQRMTLQQHCREKEQEIVMKIDEIINNDAIQKNLTKKQVEEFLDEWLRGYELHQPSDLFYQYPHIFPNTQSIILTPRQLLIETLEFFGLPQHYMNGAGHWKDWVQKKMEEKRIAQLKRPQKKVTKRPKRQKEEDKKEDEFKPPSYFDLTPFQSAFKKFLAVNPEGRTIFRQKIEASMKVIKMMFCNENGEMKEERHVDLNDLGNELNKQKMDIAPEVCENLASFLECFGEIKYEEEIIMVNPPKEDTNQNAKIAQTKKMFASEQTESKPIPKLLKKTSFQEFFDAVYKMKEFDIMMNRLDITKSTTLKAEVSQIVKEEAQQEKAKQEKRRIERSPNPYDDYVKNLKDLDSIPEVPIDAQNAIVINLFCIDENFESRSLDFVEYAFSIFGDRDYIILTQPFTVPETTLLQQFIKIPMKKNSTFDHVLYIYHKDCLLSNTLFIRKSKLEDMQYVAPLFSNLINKQQIYDDTLEAITQTASRKVAFSVFCDQSLIGIYVVSKNVNLDYYISHFCVQDHIILKEHPMTCHTKLIHTALNPLFTKNTRFILKEILRLMNKTCMYFEVQEKTLLPDVFNELVFVRARQFPHFLKRKWDFEHDKEHFERAGDLTEVQDGKRDAFDQEQAPFSLSVITKKMMSSVKVNNNTRIVVVGASDTGISFIESLLSVKDINFTHITLLAPGGIMTMHINLPGDQLKALSTNYTLEELKNLMLDARVNVLDAKMVELDKKGKKIKLDKNAELPYDYLVNTVGLIDTELQNRRLISTGLFSSPYYQQLLDKYGRDRAQIEEGAPPIFGQHPVYGNYVQGVYSIDDPYLYEEFKKTGKKDSNIDLLTRKKRPQSITIYGRTLHTIAFISGMVNRGVHPNRIHYVIPPKVFETQVQFKNNTERLIYEDKRINDPDPFDDPSVEQKIFEFMESKGIQVHKGYNLHQIDVDEETRICQGVVFRKKADNYEEIIQQIEIKKQQILERDANSENADKGFDDTQSRDGDEENQPITLEQEIEELERNKFDDIEITSRFLVTSGLVDIDKEIFYIIHENGLVYNGRLIVKSNFQTTEKDIFCCGKICEFSQRYKRLSIGRSLRLDKYNGRELGQKLAKCLLDSLDLGYLTDQIYSLGELPNLYMPIGIGAFLPGDLFYYHIKKNDYARPSKTMEAEDNRQDIVSDNIDQKQQIGHYIKFKFDNNGIIDQVTYLGTEPVSVQSLVSFVGLSEKCLNQLDVRFKNGLIPNISEFLSENWAIGLYHEWFSEFRHITKMEMLQSENIQQILDEAAKYAQGGGFLDPEFIEKIKAKISPEIISQIQQGTLDFIRENQNHLPMYYVPPKKVNVD
Protein: Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) (Q8NI08)
Organism: Homo sapiens (Human)
Function: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Estrogen receptor
- Estrogen receptor beta
- V-type proton ATPase subunit B, kidney isoform
Sequence:
MDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGATVSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDLPQDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGHTPTKPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEERKKAESQINNSAVEMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVSENLQKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMDNKSEVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWAFD
Protein: 2-hydroxyisocaproyl-CoA dehydratase activator (EC 3.-.-.-) (Q5U925)
Organism: Clostridioides difficile (Peptoclostridium difficile)
Function: Involved in the reductive branch of L-leucine fermentation. Required for the activation of (R)-2-hydroxyisocaproyl-CoA dehydratase. The reduced activator transfers one electron to the dehydratase concomitant with hydrolysis of ATP. This protein is extremely sensitive towards oxygen.
Interaction partners:
Sequence:
MYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRVLEKLYGKTGLAREDIKKVVVTGYGRMNYSDADKQISELSCHARGVNFIIPETRTIIDIGGQDAKVLKLDNNGRLLNFLMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSISSTCTVFAESEVISHLSENAKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVARNSGIVRAMAREINTEIIVPDIPQLTGALGAALYAFDEAKESQKEVKNI
Protein: Rifin (Q8I1V5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYISILLFSHPLNILLTSSQVYNQKNPYLTPHKTNPKSVKTCRSLCECELYAPSNYDNDPEMKKVKQQFDDRTSQRSHEYHKRIQENRQKCKEQCEKDIQKIILKDKIEKELTEKLGALQTEIRSDAIPTCTCQKSVGYKVEKTCLKCGGILGVGVAPSLGLLGEIGGLVINNWKNTPFYEAFVAFAQKEGIAAGKIASDAARIDTVISGIISNFEVHTINGSTLANAITLETLKDDTILTKALHFEYGSMCVNTPTDDKLICAYGMRAGLVQGKSASPEAVIRSSVKTLLKNADNVASQAAQTTANETTSGMIKAELSKIASAGANTYSAITYSVTAILVIVLVMVIIYLILRYRRKKKMKKKLQYIKLLKE
Protein: Caspase 14 (D3ZZ65)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Bleomycin hydrolase
Sequence:
MDSETINPQPLQEERYDMSGARLALTLCVTKAREGSEVDMDALERMFQYLKFESTMKRDPTAQQFLDDMDEFQQTIENWKEPVSCAFVVLMAHGEEGFLKGEDGNMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGEHRDPGEELPGDELAVIKKKNPPTIPTYTDMIHIYSTVEGFLSYRHDQKGSGFIQTLTDVFIHKKGSITELLEEITRLMANTEVMQEGKPRKVNPEIQSTLRKKLYLQ
Protein: MND1-interacting protein 1 (AtMIP1) (Q8RX22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine/threonine-protein kinase Aurora-1
- Serine/threonine-protein kinase Aurora-2
- Serine/threonine-protein kinase Aurora-3
- Homologous-pairing protein 2 homolog
- Protein XRI1
- Ubiquitin-conjugating enzyme E2 10
- Serine/threonine-protein kinase VIK
- XRI1-like protein
- Putative cyclic nucleotide-gated ion channel 9
- ATP synthase subunit beta-2, mitochondrial
Sequence:
MGCTVREKHVKPTRRIKAAAFRSDPPLCWVEKIAMSQSIVENLVYHPGLTDSGSVNLNSVTENPEENFWAYCTEEHLEEILLKHLEFLYNQAVSKLLELGYEERVALKAVLSNGHCYGELDVLTNIVNNSLSYLNSGGGGGGSNGNGEDRTETGFTDLRDLEEYSLAGMIYLLQQVKPNLSKGDAMWCLLMSELHVGRASTLDVPTNRSSCCTKEDSNVEDVGTGGTLDIAGFMAPALCRFHGGWGFGNGGGPEFSGNGFSMKGAELKLQREIDCPKRFNLSPSMKSLLKRNVAAFAAGYRASMKQKQIQSSDTIGDSKACNDPAIVKSCGQQPRKSGSEESVSTVLEKFRDLNLDDNLESVGVDDKDCVIVDLLHQVKDFEKKVKERKEWAQKNAMQAAQKVSEELAELKTLSSEREGIQLLKKGKQAVEESTAKRFTDKEIELRKACSQNDRANVIVRKLENQNAEIRAEREGSKLSASESLKACMEASKKEKKCLKKLVAWEKQILKLQDEITAEKEKIKALYKTLAQITEYEKEIEAKWRQEQKAKEEALAQMEEEQRSKEAAEGHNKRKLETLRLKIELDFQRHKDDHQRLEQELGRLKASSDSDSSHISNNAWKPKKSQGENIAKLLEEIDKLEGSYDNEANYDRECIICMKDEVSVVFLPCAHQVVCGSCSDSFFASNNGGSKVTCPCCRGLVQQRIRIFGATS
Protein: FI07620p (Q9VET1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MKLFTNKNQRNAKLLRSAALGMTLLFFGSLVIISDPLQSILDTQLSLKPGTLLHRLWLLPPLDVYINVYMFNYTNVDEFTSGRASKLQLQEVGPYVYKEVLSNHNVTYNESNNTITYSPKREYVFAPERSVGDPKIDRIRAPNIPLMGVTTLASSLSMFAALGLSAITRQLNSQPMLEMSVHDYMWGYEDHLVELASRFVPNWIDFSSFGIMEKLFREGNESNVFNMNLPEPKDKYGMRMTDAPRGYTVDSINGERGFKGWQYNEETNGTMCNRIWGSHDATLFPLDMDENDEFFLYRRTFCRRLPVKFNRTTTFNGLDAFEFVMEPDSFDSEVDNANSSCYCKNNRCLKKGVGNVSPCYYNIPLAITYPHFMHADPSLLEPFDGLQPNVSRFTSTFVVQPQLGAPMQGTHLRLQANQVVGKVNFNRMMTPFENMILPLLWVDLNIDVLCLTLRLLIHGIKWGFPLLQWSAALGMLLAGVYQLCSALLLCFWPTARQFQKVDQVERGTAVQVIGVGLGLATGLRKPSIHLDPEEQHHLLLGGGSFIPKMAKT