wanglab/gogpt-training-data huggingface dataset:
Protein: Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1) (P70606)
Organism: Rattus norvegicus (Rat)
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity).
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9EQR3}.
Interaction partners:
- Calcium-activated potassium channel subunit alpha-1
- Calcium-activated potassium channel subunit beta-2
- Calcium-activated potassium channel subunit beta-1
- Calcium-activated potassium channel subunit beta-4
- Potassium channel subfamily U member 1
- Intermediate conductance calcium-activated potassium channel protein 4
- Small conductance calcium-activated potassium channel protein 2
- Protein kinase C gamma type
- Calcium-activated potassium channel subunit beta-3
- Protein kinase C beta type
Sequence:
MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
Protein: Huntingtin interacting protein 1 (A0A8I5Y6T0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MFSNLDPPPETVSVNKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDASQQSLFDNKFDDIFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDNVKIESQRAMLQLKGRVSELEAELAEQQHLGRQATDDCEFLRTELDELKRQREDTEKAQRSLTEIEKKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLEREKKELADSFARVSEQTQRKTQEQQDVLETLKHELATSRQELQVLHGNLETSAQSEAKWLTQIAELEKEQGSLATAAAQREEEFSALRDQLESTQLKLAGAQDSMCQQIKDQRRILLAGARKAAELEIQEALGQLEEPALLISCAGATDHLLSKVNSVSSCLEQLEKSRSQYLACPEEISELLHSITLLGHLTSDTIIQGTATSLRAPPESADSLTEACRQYGRETLAYLSSLEEEGAMEKADTTAIANCLGKIKTIGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATTRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVASKDLQKEIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSHEIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGTEASPSAVQEAVPDKE
Protein: Protein phosphatase PP2A regulatory subunit B (C8VMY3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Protein phosphotase 2a 65kd regulatory sububit
- Serine/threonine-protein phosphatase PP2A catalytic subunit
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Polo-like kinase
- Protein kinase domain-containing protein
- Separin
- Ser/Thr protein phosphatase family
- GTP binding protein
- DNA damage checkpoint effector kinase
- Protein kinase regulator
Sequence:
MVDRDPGTPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSTELTPGGVGGGGAPRAPRVSFKDSSALKLPRMTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRVNLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPTSCNWFMYASSKGTIKLADMRQRALCDTHHKLFEQEEDASSRSFFSEIISSISDVRFSHDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTDPAKETEIVLQADKSAFKAKKVGVPTPMNKGANGKKSNSRTSSPAGPGSRMKKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL
Protein: Zinc finger protein ZIC 1 (Zinc finger protein of the cerebellum 1) (P46684)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
Subcellular location: Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.
Interaction partners:
- Zinc finger protein ZIC 4
- Paired box protein Pax-3
- Forkhead box protein D3
Sequence:
MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSLFAASAGGFGGPHGHTDAAGHLLFSGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPTTDNPTTSSMSPSSSAVHHTAGHSALSSNFNEWYV
Protein: Gamma-aminobutyric acid type A receptor subunit alpha5 (G3V2K2)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTM
Protein: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] (Q28901)
Organism: Bos taurus (Bovine)
Function: Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
Interaction partners:
- Hexokinase-2
- ATP-dependent 6-phosphofructokinase, liver type
- Hexokinase-1
- hexokinase
- ATP-dependent 6-phosphofructokinase, muscle type
- Fructose-1,6-bisphosphatase isozyme 2
- Fructose-2,6-bisphosphatase TIGAR
- Fructose-1,6-bisphosphatase 1
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
- Mannose-6-phosphate isomerase
Sequence:
MPLELTQSRVQKIWIPVDHRPSLPRTCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNLGEYRRDGVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLTKEGGQIAVFDATNTTRERRHMILHFPKENDFKVFFIESVCDDPTVVASNIMEVKISSPDYKDCNSRENAMDDFMKRINCYEASYQPLDPDNDDRDLSLIKVIDVGQRFLVNRVQDHIQRRIVYYLMNIHWQPRTIYLCRHGESKHNLQGKIGGDSGLSSRGRKFANALSKFVEEQNLKDLKVWTSQLKSTIQTAEALQLPYEQWKALNEIDAGVCEEMTYEEIKDTYPEEYALAEADKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVCVCLLAYFLDKSAEEMPYLKCPLHAVLKLTPIAYGCRVESIYLNVESVSTHRERSEDAKKGPNPLMRSNSH
Protein: Cation/calcium exchanger 4 (AtCCX4) (Protein CATION CALCIUM EXCHANGER 4) (Protein CATION EXCHANGER 10) (Q9SYG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Magnesium/proton exchanger
- Vacuolar cation/proton exchanger 2
- Vacuolar cation/proton exchanger 5
- Cation/H
- Sodium/calcium exchanger NCL
- Putative vacuolar cation/proton exchanger 6
- Vacuolar cation/proton exchanger 1
- Membrane fusion protein Use1
- Vacuolar cation/proton exchanger 3
Sequence:
MRAVNFMYSSNNPKFRGIFNGLCAIILFIFFFDQSDIYRNPLLKNLSFVDSSGKFNRGFSQFTVPRRHLSEVDTNGSSGNSSLSGDSTVSCSGLHEHRGYADQCEFLKSNPICSPDGFFDYLKFFYCSCRDFKILGYILLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGSDKGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVKIDKKCFIRDLSFFLFTLVALMVILMVGKVTVGIAIAFVSIYVFYASLVAANEILRKHSRRLKLDSITPLLPMQGSVFSSPSVEEDIPMYSPLMELDTGEGPPRLHDSLPQWMWATNVAIYSNHFAKANVHDEERPPWGWTEDGAEVESSLCSKITSLLETPLTVPRRLTIPLIEEDSWSKTYAVASVSLAPVLLSFLWSSQDDTSLQARIVAYFIGIAIGSTLGYLAFKNTEPDRPPQIYLIPWVLGGFIMSIVWFYMIANELVALLVTFGGIYGINPSILGLTVLAWGNSMGDLVSNIALSMNGGDGVQIALSGCYAGPMFNTLVGLGMSMFLGAWSKSPETYMIPEDNSLFYTLGFLIFGLIWSLVMLPRNEMRPNKVMGIGLITLYLIFVTFRLSSAMGFIPWAS
Protein: Rhoptry neck protein 12 (Q8IJM8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKRVYTCLCFICLFFLCILKGVYNVKTQKNEGIIIDKEGKENDNGNSDRNTPNNNNRLNRMTLNKEMYEKHNKMNNEEDNNKNINYDLSNLKDGMKKKHFGSNSSEDKTNKKSSINSVLEKYQHTKHEEKNLQNLNKNMMTHENDDSMKSIFISEESFESAKNVCQFIVMQNDYFKNFCNITSLVYDIEKLKKNNHKIYEEILSNSYENNNGSKFKLLKEINHTKVFKEMDNTNPKFSILFLYDKFCYGGIPLACSNLMKYDNVFDINEQSETTNKPDDNVNMEEMENYIINQTGMENGFEENVSDLTQE
Protein: Exosome-associated protein 3 (Q582G1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosomal RNA processing protein 6
- RNasePH-like protein exosome-associated protein 1 Rrp42 homologue
Sequence:
MQFDEDIVPLMEKMNAALDRVHQCLLPLLSSLDEDMLVSNYTVDEQARISLSAASALLFLTYAHDRLLNRAQGAGEDQQLMLKINRVTEYIGKLREITSLECKPRSSKGQTQQEGHDGDVSEVRNRKRERGEPPEKATKYAKVDDGRASKGGALENVKADGEDASVDPYGDAILFKEIERKGGKTSALVQNLLQHVTGTNNS
Protein: Transposon Ty1-LR3 Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)] (P0C2I6)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVQYGDFYWVSKRYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSASQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKPISEINLRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSNNETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDPPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAAKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: Neogenin variant 1 (Q3S3D7)
Organism: Xenopus borealis (Kenyan clawed frog)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAVRSPPGSIVRVTRGLFAVSILFSVWKKQTWAANTAGSGFRTFTPFYFLTEPADTVTLRGFAAVLNCSAYADPTPKIEWKKDGTFLNLVSDDRRRLLPDGSLLITSVVHSKHNKPDEGIYQCVATVESLGSIVSHTARLSVAGLPRFSSQPESSSVYLGDSIVLNCDVSPELVPFVQWEQNKAPRELDSRVAILLNGSLVISNANESDAGLYRCAVGGGSSIKYSEEAEIKVLQDTGEERPMVFLRQPLPLTRVSGQTALLTCVVSGYPIPSVRWSHNLKEILNENSEKLTFVAGGNLQISSVTEEDAGIYTCVADNGNQTIQAHAELSIQVPPVFRVKPSNTHAHESRDIVFKCEVTGKPTPTVKWVKNGDMVIPSDYFKIVEDHDLQVLGLVRSDEGFYQCIVENEVGNVQAAAQLIILEPGVTIPTSPTPSLTRATAHNVAATPGGPLPSSPRDVVASLVSTRFIKLTWRMPADPHGENLIYHVFYSKESMNRERVENTTRPGEMQVTIQNLLPETVYYFRVVALNQHGASESSHSLKVETHPEVQVPGPAPNFKATSVSSTSVSVSWETPLSGNGEIQSYKLYYLEKGADNEQDIDVSGQSYTLNGLKKYTEYTFRVVAFNKHGPGVSTQDVTVRTLSDVPSAAPQNLTLGVRSSQSILVQWQPPPLGSQNGLIVGYKARYRKTTRKSETSEMLVDAQLSYLFTGLERDTEYSFRVVALTVNGSGPATDWVSAETFESDLDESRVPDVPSSLHVRPLVTNIVVSWTPPENQHQVVVRGYAIGYGLGSPHAQTVRVDHKQRYYTIDNLDPSSHYVISLRAFNNVGEGIPLYESAVTRQHTDPSDVDVFVVHAPYTPVPEPSPMLPPVGVQATILGSDAVRLTWADNSLPKNQKITDSRYYTVRWKTNIPANTKYKMANSTTLIYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFESVPSSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKMTGYIIYYSTDAQAELHDWVIEPVIGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVLFRTPKASSISGKGVRPSDPGSNSGSTLGGSNSHHGSPTSLDQNMLLTIIVSLGVIIVLVAVVIAAICSRRSSSHHKKKRAASKSVNGSHKYKANSKDVKPPDLWIHHERLELKPTDKSPETNPILTDTPLPRSPQDLTPGDSTTEGSIHQHSNSYRGLESEDSVSSLAARRGMRPKIMMPFDSQPPQPVVSAHPIHSHDNSHHFRSVPGFMLHVLGGPPQAAESVRHTPSCDTVVAASSSSQTGPEDPEPSGGSFLPGSLDEDTVPSVPTAHIRPSHPLKSFAVPAVPTPASGATYEPPLPSSPLLQSQCPTALSVKTASLGTLGRVRPPLSVTVPSAPEPLETTRMLEGSECSYEPDELSKEMAHLEGLMKDLNAITPA
Protein: Serine/threonine-protein kinase PHO85 (A0A1D8PDA6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Pho81p
- Pcl1p
- Nucleoporin NSP1
- Pcl5p
- G2/mitotic-specific cyclin-4
- Cyclin-dependent kinases regulatory subunit
- G2/mitotic-specific cyclin CLB2
- Mitosis inhibitor protein kinase SWE1
- Amino acid starvation-responsive transcription factor
- Cell division control protein
Sequence:
MTGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKELDHENIVTLYDVIHTENKLTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSAGCIFAEMCTGKPLFPGTANEDQLIKIFRLMGTPNERTWPGISQYTNYKNNWQIFVPQDLRLIVPNLDSMGLNLLQSLLQMRPESRITARQALQHPWFHEITMPNAVPQHLSDPYQQQQQQQQQQQQQQHPHQPIIDQQY
Protein: Diuretic hormone 1 (DH-1) (Diuretic peptide 1) (DP-1) (Mas-DH) (P21819)
Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Function: Regulation of fluid secretion.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MMWWAIWCVMVVVSSAASAAPAPDSAPMDLVQIDSAGPDDESLGYAVSSLEGRYGAEAPWLYLLAEMPRDSQIGRAAVKRRMPSLSIDLPMSVLRQKLSLEKERKVHALRAAANRNFLNDIGKRGLQWSRSEQPSAYY
Protein: RmtA (C8V494)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Histone H4.2
- Histone H4.1
- Small ribosomal subunit protein uS5
- Pre-RNA splicing factor Srp2, putative
- Nucleolin protein Nsr1, putative
- rRNA 2'-O-methyltransferase fibrillarin
- Protein arginine N-methyltransferase 2
- Histone H2A
- Nucleolar GTP-binding protein 1
- Ribosome assembly protein Noc2, putative
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYARDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
Protein: F-box only protein 7 (Q68FS3)
Organism: Rattus norvegicus (Rat)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity). {ECO:0000250}.
Interaction partners:
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase parkin
- Polyamine-transporting ATPase 13A2
- Vacuolar protein sorting-associated protein 35
- 85/88 kDa calcium-independent phospholipase A2
- Auxilin
- Serine/threonine-protein kinase PINK1, mitochondrial
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
- Glucosylceramidase
Sequence:
MKLRVRLQKRTQPLEVPESEPTLGQLRAHLIQDLLPTLGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDEMPAPNLPSSTDSEHSSLQNNDQPPLAATSSQANIPDEQGSDSSHGQVTQYDAWTDDSMEGPSHSAEAVSIQDAMSVEEASGFHPLEPMLCSETEDGQVPHSLEALYQSAGCSTVSDALIVLVHLLMLESGYIPQGTEAKAASMPEKWKSSGVYKLQYTHPLCEGGSAVLTCVPLGKLIMINATIKVNGGIKNVKSVQLKPGAYVRRAEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDSTIRGPDTDWKELYRKKHIQRKEAQRMRHVMYLPSVHPIPFCPIPVYPRPYLPTTLLPPGIIGGEYDERPILPSVGDPVTSLIPRPGEPPSQFRPVRPRFDPVGPLPGSNSLLPGRASPNNRFPFRPGRGRSADNRLPYL
Protein: Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) (P18754)
Organism: Homo sapiens (Human)
Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:16820410, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:2236072}. Chromosome {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:20668449}. Cytoplasm {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:20668449}. Note=Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:20668449}.
Interaction partners:
- GTP-binding nuclear protein Ran
- Ran GTPase-activating protein 1
- Importin subunit alpha-3
- Ran-specific GTPase-activating protein
- Histone H2A type 2-C
- Histone H2A type 2-A
- Histone H2B type 2-E
- Ran-binding protein 3
- E3 SUMO-protein ligase RanBP2
- Importin subunit alpha-4
Sequence:
MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Protein: Phosphodiesterase (EC 3.1.4.-) (Q6IQY6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPEANYLLSVSWGYIKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPIDT
Protein: Down syndrome cell adhesion molecule 1, isoform AT (Q0E9L4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQFYITEAENEYVIKGNAAVVKCKIPSFVADFVQVEAWVDEEGMELWRNNATDAYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPIGSVAPTISGDRLQEQTRKLGHSFSILCQGQAYPHPVFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMAPPKLAPFDFGDSPANFEDSVSVSCLVSSGDLPIDIEWLFNGESISYASGIAVLRGGKRTSVLTIDSVHAGHAGNYSCKAKNKAASSEYSAALIVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPSRDLPELSAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGNHHKDDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper) (O02373)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues.
Interaction partners:
- UDP-glucuronic acid decarboxylase 1
- UDP-glucose 4-epimerase
- UTP--glucose-1-phosphate uridylyltransferase
- Probable galactose-1-phosphate uridylyltransferase
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
- SURF1-like protein
- chitin synthase
- Protein wingless
- Glucose-6-phosphate isomerase
- GH11113p
Sequence:
MKVCCIGAGYVGGPTCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLFFSTDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAESIMHILRANQKPGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGHQAVEKLSWIYEHWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKILDHERLQQIGFHVQTIGKKYQRTGLLRSWGIVPQL