Protein: Serine/threonine-protein kinase ATR (AtATR) (EC 2.7.11.1) (Ataxia telangiectasia-mutated and Rad3-related homolog) (DNA repair protein ATR) (Rad3-like protein) (AtRAD3) (Q9FKS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis process. Required for the basal expression of RNR1 (ribonucleotide reductase large subunit). Acts in concert with telomerase to maintain telomeric DNA tracts. Not required for telomere length homeostasis. Required for effective immune responses that involve activation of DNA damage responses.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell cycle checkpoint protein RAD17
- DNA repair protein RAD50
- Nibrin homolog
- Serine/threonine-protein kinase ATM
- Double-strand break repair protein MRE11
- Probable inactive protein kinase At3g63330
- Dentin sialophosphoprotein-like protein
- Checkpoint protein
- Transcription coactivator
- BRCT domain-containing protein At4g02110
Sequence:
MAKDDNNLSSLVHELRERVAASASTPANNLRHSSGDEDALEIRFRAVIPNLLNTYVVPSLGNGREVTAVLKLVGHTARNIPGVFYHGTPSAILPVIARIIPFFAEPEFVPGHGVLLETVGSLLMLLRSNSRKAYRIFFHDALQAIQDMQPIASLHSIEPEVCESHIPFRCFCMSFSGIGGDLPDANKPRDGDGLVLNLLGANRWQPFATCILKLICKCLTEGTLYVQGLIHTSFFKAACSLVCCGGADVQMACFEFATLVGSILTFNILPHVALIQSIILLLSADEGLPVYRNTIYDSTIGRFLTAVYSSCSDAAVKLTAESLVLVLSHALQRTKSEELKASLCSAYVRIVKSCPPCIWKIHCLLELLHLPEPCFQLIECFKAVLIVLGPGCVRVETTKCGSHTSATSDRPVQGINAGKKRHIEDESTYKRKRQKVGDDIRRGVYFAPEFADETDGKDAASLREMLISTVESLKPPPAGPSLSQTESSIVALSMLTNAFCFCPWTDMTHRLFNQMYAWIPWIAGQVEETNPIMFDISIYLEGIHNLLLVGVDPQYEYTSKGNDLVAIQFLLKLPWTHYMLFKTPSSLVKSKCLSVGIWTKLGLQDGSDFDIFSWSLSDDFEQVQAVAAISMPLKVLFSGLGALLHMFPKLEHLLEEKELMIKKAIPQSLGFLSCLYGSSTTDSEKTACHLLLHEDLKKDETLNSLLQGFRCSKCDKFIEREDEKHFRIIETPEMVKLKMDHHRDYFNLQSLYFNLLYDESSEETQLACVEVIRRILGHTSPDILVRTRSQWIRCLQYLLVHVNTDVREAFCAQIGIFVQHPIVSCLFLSEDATEKSCERNFFNLIEHSLAAAKDLLVIQTLLETTAEVMVAVDVTSELFLICLFLLIDQLDHPNLIVRINASKLINRSCYIHVKGGFATLLSTASHIQNELFDNLSVRLTSRPNVVREFAEAVLGVETEELVRKMVPAVLPKLLVYWQENAQAANTLNELAKLIDTDVVPLIVNWLPRVLAFALNQEEDKNLLSVLQLYHSQIGSDNQEIFAAALPALLDELVCFVDIADTPETDRRLQRLPDAIKKISKVLTNAEDLPGFLQNHFVGLLNSIDRKMLHADDIFLQKQALKRIKLLIEMMGHYLSTYVPKLMVLLMHAIEKDALQSEGLLVLHFFTRKLADVSPSSIKYVISQIFAALIPFLEKEKEGPHVYLDEVVKILEELVLKNRDIVKEHICEFPLLPSIPSLGELNNAIQEARGLMSLKDQLRDIVNGMKHENLNVRYMVACELSKLLYNRNEDVAALIAGELVSDMEILSSLITYLLQGCAEESRTTVGQRLKLVCADCLGAIGAIDPAKVRVASCSRFKIQCSDDDLIFELIHKHLARAFRAAQDTIIQDSAALAIQELLKIAGCEPSLAGNVVVLTPQEHVQVNVSGSRRCGGNNEVKDRGQKLWDRFSNYVKELIAPCLTSRFQLPNVSDPGSAGPIYRPSMSFRRWLSYWIRKLTAFATGSRVSIFAACRGIVRHDMQTATYLLPYLVLDVVCHGTEAARLSISEEILSVLDAAASENSGVTINSFGVGQSEVCVQAVFTLLDNLGQWVDDVKQGVALSSSLQSSGGRQVAPKSKDQVSNSTTEQDHLLVQCKYVLELLLAIPKVTLARASFRCQAYARSLMYLESHVRGKSGSLNPAAEKTGIFENADVSSLMGIYSCLDEPDGLSGFASLSKSLNLQDQLLINKKSGNWADVFTACEQALQMEPTSVQRHSDVLNCLLNMCHHQTMVTHVDGLISRVPEYKKTWCTQGVQAAWRLGKWDLMDEYLDGADAEGLLFSSSDSNASFDRDVAKILHAMMKKDQYSVAEGIAISKQALIAPLAAAGMDSYTRAYPFVVKLHLLRELEDFQAVLNGDSYLEKSFSTSDQVFSKAVDNWENRLRFTQSSLWTREPLLAFRRLVFGASGLGAQVGNCWLQYAKLCRLAGHYETAHRAILEAQASGAPNVHMEKAKLLWITKRSDSAIIELQQSLLNMPEGVVDSTVISSINSLLMAPPNPEPTVRNTQSFKEKKDVAKTLLLYSKWIHHSGQKQKKDVLNLYTQVKELLPWEKGYFHLAKYYDELYVDARKCQQESSVFSSAGSKKGSVSSNLSTEKAGWDYLFKGMYFYAKALHSGHKNLFQALPRLLTLWFDFGTIYKTSGSAGNKELKSTHMKIMSLMRGCLKDLPTYQWLTVLPQLVSRICHQNADTVLMVKNIITSVLHQFPQQGLWIMAAVSKSTVPARREAAAEIIQGARKGFNQSDRGHNLFIQFASLTDHFIKLCFHGGQPRSKVINIATEFSALKRMMPLDIIMPIQQSLTISLPAFHMNNNERHSASVFSGSDLPTISGIADEAEILSSLQRPKKIILLGNDGIEYPFLCKPKDDLRKDARMMEFTAMINRLLSKYPESRRRKLYIRTFAVAPLTEDCGLVEWVPHTRGLRHILQDIYISCGKFDRQKTNPQIKRIYDQCAVKKEYEMLKTKILPMFPPVFHKWFLTTFSEPAAWFRSRVAYAHTTAVWSMVGHIVGLGDRHGENILFDSTSGDCVHVDFSCLFDKGLQLEKPELVPFRLTQNMIDGLGITGYEGIFMRVCEITLTVLRTHRETLMSILETFIHDPLVEWTKSHKSSGVEVQNPHAQRAISSIEARLQGVVVGVPLPVEGQARRLIADAVSLENLGKMYIWWMPWF