wanglab/gogpt-training-data huggingface dataset:
Protein: Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1) (Gelatin-binding protein) (Q15848)
Organism: Homo sapiens (Human)
Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Subcellular location: Secreted {ECO:0000269|PubMed:8947845}.
Interaction partners:
- Adiponectin receptor protein 2
- Adiponectin receptor protein 1
- Cadherin-13
- Leptin
- Complement factor D
- Resistin
- Peroxisome proliferator-activated receptor gamma
- Insulin
- Perilipin-1
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Sequence:
MLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIPGHPGHNGAPGRDGRDGTPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSVGLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLYHDTN
Protein: Mannan endo-1,6-alpha-mannosidase DCW1 (EC 3.2.1.101) (Defective cell wall 1) (Endo-alpha-1->6-D-mannanase DCW1) (Q6FLP9)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Required for normal synthesis of the cell wall.
Subcellular location: Secreted, cell wall {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Mannan endo-1,6-alpha-mannosidase
- Autophagy-related protein 17
- Autophagy-related protein 31
- Autophagy-related protein 13
Sequence:
MRLVTLLSGLVSLVSVFGLELDLDDYASLQNATALVAYGLMDYYTGDQYGKTVGMFSDPYYWWQAGGAWGCMLDYWYFMQNDTYNDKIMAALLHQTGDNNDYVPLNQSTTEGNDDQAFWGIAVMQAAERKFPNPPDDKPQWLYLTQAVFNTMALRWDSETCGGGLRWQIFVWNSGYDYKNTVSNGALFHIAARLARYTGNQSYVDWAERVYDWMEDVHLIDNGTYRYVYDGVSINDNCTTVTKYQWTYNQGLMLSGSAYLFNMTGSDLWHERTHAFLNASRVFFNNSILYEAACQGPNTCNTDQRSFKAYFARFLGSTAELVPETRQQIMTWLNTSALAAAKSCSGGTDGHTCGLNWFRDDWDGMYGLGEQMAALEVMVNTQALKRAPPYNATNGGNSTGDGAAGTKPHPTNLAPLHITGGSRAGAGIITAIIGISIIACALWLVY
Protein: 5-oxoprolinase 1 (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Protein OXOPROLINASE 1) (Pyroglutamase) (Q9FIZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Acts in the glutathione degradation pathway.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:18768907}.
Interaction partners:
- Glutathione hydrolase 3
- Putative inactive glutathione hydrolase 4
- Glutathione hydrolase 2
- Glutathione hydrolase 1
- Gamma-glutamylcyclotransferase 2-2
- Gamma-glutamylcyclotransferase 2-3
- Gamma-glutamylcyclotransferase 2-1
- Glutamate--cysteine ligase, chloroplastic
- P-loop nucleoside triphosphate hydrolase superfamily protein
- TRAF-like family protein
Sequence:
MGTVIEGKLRFCIDRGGTFTDVYAEIPGHSDGHVLKLLSVDPSNYDDAPVEGIRRILEEYTGKKIPRTSKIPTDKIQWIRMGTTVATNALLERKGERIALCVTKGFKDLLQIGNQARPDIFDLTVAKPSNLYEEVIEVDERVVLALEDDDDDEGSLIKGVSGEFLRVVKPFDGEGLKPLLKGLLDKGISCLAVVLMHSYTYPKHEMDVEKLALEMGFRHVSLSSALTPMVRAVPRGLTATVDAYLTPVIKEYLSGFISKFDDDLGKVNVLFMQSDGGLAPESRFSGHKAVLSGPAGGVVGYSQTLFGLETEKPLIGFDMGGTSTDVSRYDGSYEQVIETQIAGTIIQAPQLDINTVAAGGGSKLKFQFGAFRVGPDSVGAHPGPVCYRKGGELAVTDANLVLGFVIPDYFPSIFGPNEDQPLDVAATREAFEKLAGQINIYRKSQDPSAKDMSVEEIAMGFVSVANETMCRPIRQLTEMKGHETKNHALACFGGAGPQHACAIARSLGMKEVLVHRYCGILSAYGMGLADVIEDAQEPYSAVYGPESLSEVFRRETVLLREVREKLQEQGFGDGNISTETYLNLRYDGTDTAIMVKGKKTGDGSAFDYAAEFLKLFEQEYGFKLQNRNLLICDVRVRGIGVTSILKPRAVEAAPVTPKVERHYKVYFEGGWHDTPLFKLENLGFGHEILGPAIIMNGNSTVIVEPQCKAIITKYGNIKIEVEPATSSVKLAENVADVVQLSIFNHRFMGIAEQMGRTLQRTSISTNIKERLDFSCALFSPDGGLVANAPHVPVHLGAMSSTVRWQLKHWGENLNEGDVLVTNHPCAGGSHLPDITVITPVFDKGKLVFFVASRGHHAEVGGITPGSMPPFSKAIWEEGAAIKAFKVVEKGVFQEEGIVKLLQFPSSDETTTKIPGTRRIQDNLSDLQAQIAANQRGISLIKELIEQYGLGTVQAYMKYVQLNAEEAVREMLKSVANRVSSETPNSRVGNSVTIEEEDYMDDGSIIHLKLTIDADKGEASFDFTGTSPEVYGNWNAPEAVTSAAVIYCLRCLVNVDIPLNQGCLAPVEIRIPAGSFLSPSEKAAVVGGNVLTSQRVTDVVLTAFQACACSQGCMNNLTFGDDTFGYYETIGGGCGAGPTWNGTSGVQCHMTNTRMTDPEIFEQRYPVLLHRFGLRENSGGNGLHKGGDGLVREIEFRKPVVVSILSERRVHSPRGLNGGQNGLRGANYLITKDKRRIYLGGKNTVHVEAGEILQILTPGGGGFGSNI
Protein: Transposon Ty2-DR3 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)] (Q07791)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLHQNPHSLHGSAAASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAKTKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTSRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTRTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHIKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQDNQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSLNPLQLDKEPVQKVRAPKEVDADISEYNILPSTIRSRTPHIINKESTEMGGTIESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAVCDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTNKSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNKDNKEKDRYVEAYHKEISQLLKMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGEGDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKMNIADVMTKPLPIKTFKLLTNKWIH
Protein: Chemosensory protein B 53a (A1ZAG5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLELILILNVVHLSLQISYEFEIEDESIYSDCSDVPPGTLNISGLFDLTNYTTTITADGLSVSGNMTSVFNAQPTDRIELTGNLLFFDRGAWQPTTLNMMVRDFCAVMYDKKQLWYTDWSSHVVNRDEIKDNCIKVPGTLFLIESYNMKLVFGSGIPLGTGRYSIRVQVFAYDQKGKKRPNNVCYEVKGNFYKESNICISKPILITINVLAESLKSQMSSTNHANI
Protein: HTH-type transcriptional repressor CsqR (Regulator of sulfoquinovose catabolism) (P32144)
Organism: Escherichia coli (strain K12)
Function: Involved in the regulation of the sulfoquinovose operon. Represses the expression of the yihUTS operon and of the yihV and csqR genes. Binds DNA inside the spacer between the bidirectional transcription units comprising the yihUTS operon and the yihV gene, and upstream the csqR gene itself.
Interaction partners:
- Sulfofructose kinase
- Sulfofructosephosphate aldolase
- 3-sulfolactaldehyde reductase
- Sulfoquinovose isomerase
- Uncharacterized protein YihR
- Sulfoquinovosidase
- Putative 2,3-dihydroxypropane-1-sulfonate exporter
- Putative sulfoquinovose importer
Sequence:
MSLTELTGNPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSVVNTAFEQREVSQTEEKKAIAEAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVADFRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRLQDSQIEIILPQEDA
Protein: Putative transporter, CorA family (A0A0H2UR86)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVLEKQLGNGCTWIDLDLGKLNKLEDLSEIYGLDKETIEYALDRNERAHMDYHRESETVTFIYNVLDVKKDKAYYETFPMTFIVEHRRLITISNTKNAYVIEQMTRYLENHDTLSIYKFLFASLEIISNAYYPVIEQMDKSRDEVNDLLRQRTTKKNLFVLSDLETGMVYLTAAAKQNRILLEHIQGHALYRSFDEIEREQFDDAMIEAHQLVSMTDLISQILQQLSASYNNILNNNLNDNLTTLTIISVLLAVLAVVTGFFGMNVPLPLTDEPHAWLYISLASAGLWIVLSLLLRKIAKKS
Protein: MIP07141p (Seminal fluid protein 26Ac) (C0PV13)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKIHLIFVIVSLVLAKTIADECLTCDWKSNIHCGKVADGSCVFTALNRCQVERISCRREQKKLKPFTEIVKGKCPKDKEKCAKM
Protein: SUMO-conjugating enzyme UBC9-B (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9-B) (SUMO-protein ligase B) (Ubiquitin carrier protein 9-B) (Ubiquitin carrier protein I-B) (Ubiquitin-conjugating enzyme E2 I-B) (Ubiquitin-protein ligase I-B) (Q9DDJ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Small ubiquitin-related modifier 1
- Si:ch1073-55a19.2.
- SUMO-activating enzyme subunit 2
- Small ubiquitin-related modifier 3-like
- Small ubiquitin-related modifier
- Small ubiquitin-related modifier 2
- SUMO-activating enzyme subunit 1
- TAR DNA-binding protein 43
- Ran GTPase-activating protein 1
- Ran GTPase-activating protein 1
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFSP
Protein: Moladietz, isoform G (Q7KT87)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSANYRHALQRGLPFPILTVAEYFSLGREGFSWGGQYRAAGYFASIMLWASLASWLLMNLLLIAVPRYGAYMKALTGALLVCTTVGYHCLLPKRPLSIHLEGGRLEFHFGWCYWLVLVAGILCFIAGVLISIIDLVWPHTFSTVLEVYYGTPYDRHVILEESSDVRYRKPRNSRSLEDPPGLGSRILRRLSSKARDLQPGTAPRRDSPAGVSSSGGVENKGFQSDAPKSPWRYPFRRSQQMAQQQHSHPLHQHPLQQHHQHHQHHHQQQLQFVGGPVVQHPMHHMQRTMSQDSGSSIASAAVQISPLHKHALARMLPNPPVERIRDMDHW
Protein: Refilin-B (Regulator of filamin protein B) (RefilinB) (Q8N5W9)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5SVD0}. Note=Colocalizes with FLNA along actin bundle-like structures. {ECO:0000250|UniProtKB:Q5SVD0}.
Interaction partners:
- Cystic fibrosis transmembrane conductance regulator
Sequence:
MVGRLSLQDVPELVDAKKKGDGVLDSPDSGLPPSPSPSHWGLAAGGGGGERAAAPGTLEPDAAAATPAAPSPASLPLAPGCALRLCPLSFGEGVEFDPLPPKEVRYTSLVKYDSERHFIDDVQLPLGLAVASCSQTVTCVPNGTWRNYKAEVRFEPRHRPTRFLSTTIVYPKYPKAVYTTTLDYNCRKTLRRFLSSVELEAAELPGSDDLSDEC
Protein: Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (O16797)
Organism: Drosophila melanogaster (Fruit fly)
Function: The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS2
- Eukaryotic translation elongation factor 2
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL30
Sequence:
MSHRKFSAPRHGSMAFYPKKRSARHRGKVKAFPKDDASKPVHLTCFIGYKAGMTHIVREADRPGSKINKKEVVEAVTVLETPPMIVVGAVGYIETPFGLRALVNVWAQHLSEECRRRFYKNWYKSKKKAFTKASKKWTDDLGKKSIENDFRKMLRYCKVIRVIAHSQIRLIKQRQKKAHVMEIQLNGGSIEDKVKWAREHLEKPIQVSNVFGQDEMIDCVGVTKGKGFKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPSRVSTTVARAGQKGYHHRTEINKKIYRIGAGIHTKDGKVIKNNASTEYDLTDKSITPMGGFPHYGEVNNDFVMIKGCCIGSKKRIITLRKSLLKHTKRSALEQIKLKFIDTSSKMGHGRFQTPADKLAFMGPLKKDRLKEEAAATTAAAAAATTTSA
Protein: Nickel ABC transporter, permease protein, putative (Q880R2)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Nickel ABC transporter, permease protein
- Nickel ABC transporter, periplasmic nickel-binding protein, putative
- ABC-type dipeptide transporter
- ABC-type dipeptide transporter
- ABC-type dipeptide transporter
- ABC-type dipeptide transporter
- ABC-type dipeptide transporter
- ABC-type dipeptide transporter
- ABC-type dipeptide transporter
- Glutathione import ATP-binding protein GsiA
Sequence:
MTIFDDRLARLTQAVLTSKTPSAAQWRRRSNLSRVIEAVRPLLRRPGFVLAVALVAFALLAALAPNLLTSYAPYATSPTDKLIPPNAVHWFGTDELGRDLYTRVVHGSSLSVQAALLAVGIAMAGGLSLGVISGFAGGRIDAVIMRFIDVLLALPGLLLALAIVTAIGFGTLPVAIALGVGIIPGFARTTRAEVLRVKTLPYVEAARLGGASWTRTLLRHILPNAWGPVAVLATLDFGAAILATAGLSFLGFGAEPPAAEWGTLIANGRHFLMTAPWVSLLPGLFLVGVVFSFNHIARTLEEVQR
Protein: CIN85 and CD2AP related, isoform D (Q86PF3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVKMLAPSEVAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGGAGSASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEPRGASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIMSRSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQLNNHQDASSSRVAQLEQRVDKLEGLVLNQQRTIEELVNALKSEAERVKILRSELDKYAQCVTQV
Protein: CASP8 protein (Q6NVI2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGSHSVAQAGVQWCDLGSLQPPPPWFG
Protein: Translation initiation factor RLI1 (ATP-binding cassette sub-family E member RLI1) (RNase L inhibitor) (Q03195)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15277527, ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}. Nucleus {ECO:0000269|PubMed:15277527, ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}.
Interaction partners:
- Eukaryotic peptide chain release factor subunit 1
- Eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit A
- Protein DOM34
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein eS6A
Sequence:
MSDKNSRIAIVSADKCKPKKCRQECKRSCPVVKTGKLCIEVTPTSKIAFISEILCIGCGICVKKCPFDAIQIINLPTNLEAHVTHRYSANSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILAGKQKPNLGRFDDPPEWQEIIKYFRGSELQNYFTKMLEDDIKAIIKPQYVDNIPRAIKGPVQKVGELLKLRMEKSPEDVKRYIKILQLENVLKRDIEKLSGGELQRFAIGMSCVQEADVYMFDEPSSYLDVKQRLNAAQIIRSLLAPTKYVICVEHDLSVLDYLSDFVCIIYGVPSVYGVVTLPASVREGINIFLDGHIPAENLRFRTEALQFRIADATEDLQNDSASRAFSYPSLKKTQGDFVLNVEEGEFSDSEILVMMGENGTGKTTLIKLLAGALKPDEGQDIPKLNVSMKPQKIAPKFPGTVRQLFFKKIRGQFLNPQFQTDVVKPLRIDDIIDQEVQHLSGGELQRVAIVLALGIPADIYLIDEPSAYLDSEQRIICSKVIRRFILHNKKTAFIVEHDFIMATYLADKVIVFEGIPSKNAHARAPESLLTGCNRFLKNLNVTFRRDPNSFRPRINKLDSQMDKEQKSSGNYFFLDNTGI
Protein: Target of rapamycin complex subunit LST8 (TORC subunit LST8) (Lethal with SEC13 protein 8) (P41318)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. LST8 is involved in the negative regulation of transcription factors GLN3 and RTG1-RTG3, limiting the synthesis of alpha-ketoglutarate, glutamate and glutamine. LST8 is required for targeting of amino acid permeases (AAPs) to the plasma membrane. TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. LST8 is involved in maintenance of cell wall integrity. LST8 modulates TOR2 kinase activity.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also localizes to membranous structures both proximal to, yet distinct from, the plasma membrane as well as within the cell interior, probably endosomal or Golgi membranes.
Interaction partners:
- Serine/threonine-protein kinase TOR1
- Target of rapamycin complex 2 subunit TSC11
- Target of rapamycin complex 2 subunit AVO1
- Serine/threonine-protein kinase TOR2
- Target of rapamycin complex 2 subunit AVO2
- Target of rapamycin complex 1 subunit KOG1
- Target of rapamycin complex 2 subunit BIT61
- Target of rapamycin complex 1 subunit TCO89
- Type 2A phosphatase-associated protein 42
- Serine/threonine-protein kinase SCH9
Sequence:
MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV
Protein: Ferredoxin--nitrite reductase, chloroplastic (NiR) (EC 1.7.7.1) (Q39161)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the six-electron reduction of nitrite to ammonium.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11402201}.
Interaction partners:
- Nitrate reductase 1
- Nitrate reductase 2
- Glutamine synthetase cytosolic isozyme 1-3
- Glutamine synthetase cytosolic isozyme 1-2
- Glutamine synthetase cytosolic isozyme 1-1
- Glutamine synthetase, chloroplastic/mitochondrial
- Glutamine synthetase cytosolic isozyme 1-5
- Glutamine synthetase cytosolic isozyme 1-4
- S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplastic
- High-affinity nitrate transporter 2.1
Sequence:
MTSFSLTFTSPLLPSSSTKPKRSVLVAAAQTTAPAESTASVDADRLEPRVELKDGFFILKEKFRKGINPQEKVKIEREPMKLFMENGIEELAKKSMEELDSEKSSKDDIDVRLKWLGLFHRRKHQYGKFMMRLKLPNGVTTSAQTRYLASVIRKYGEDGCADVTTRQNWQIRGVVLPDVPEILKGLASVGLTSLQSGMDNVRNPVGNPIAGIDPEEIVDTRPYTNLLSQFITANSQGNPDFTNLPRKWNVCVVGTHDLYEHPHINDLAYMPANKDGRFGFNLLVGGFFSPKRCEEAIPLDAWVPADDVLPLCKAVLEAYRDLGTRGNRQKTRMMWLIDELGVEGFRTEVEKRMPNGKLERGSSEDLVNKQWERRDYFGVNPQKQEGLSFVGLHVPVGRLQADDMDELARLADTYGSGELRLTVEQNIIIPNVETSKTEALLQEPFLKNRFSPEPSILMKGLVACTGSQFCGQAIIETKLRALKVTEEVERLVSVPRPIRMHWTGCPNTCGQVQVADIGFMGCLTRGEEGKPVEGADVYVGGRIGSDSHIGEIYKKGVRVTELVPLVAEILIKEFGAVPREREENED
Protein: Uncharacterized protein C2D10.19c (O74809)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mannose-1-phosphate guanyltransferase
- Fumarate reductase
- Protein ral2
- Membrane-anchored protein 1
Sequence:
MPHRNDRRKSASKAPNAIIHGRVASKKTIKKQLRNGKYSLKRLAEKGIHLDDIAMEIDNASKKNISKDKSLNENLFGKTEAGKQKDFMNIEPTCKGTILGAPPAL
Protein: Rab-5 (I7FXD3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
AARNAGTARPGGPNRTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDATIKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFQKAKNWVKELQRQASPNIVMALAGNKADVANKRTVEYEEANAYAEDNALLFMETSAKTSMNVNDIFMAIAKKLPIGPAQGEPTGTVDMNQPQQQQKGSCCK
Protein: ADP-ribosylation factor 3 (P61205)
Organism: Mus musculus (Mouse)
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular location: Golgi apparatus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Coatomer subunit beta
- Phosphatidylinositol 4-kinase beta
- ADP-ribosylation factor GTPase-activating protein 1
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- Cytohesin-2
- ADP-ribosylation factor GTPase-activating protein 2
- ADP-ribosylation factor-binding protein GGA1
- AP-1 complex subunit gamma-1
- Coatomer subunit beta'
- Coatomer subunit gamma-1
Sequence:
MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK