wanglab/gogpt-training-data huggingface dataset:
Protein: Myosin-15 (Myosin XI I) (AtXI-I) (Q0WPU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in trafficking of Golgi stacks and mitochondria. Plays a role in nuclear shape determination. Drives nuclear movement along actin filaments. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17288617, ECO:0000269|PubMed:17500056}. Nucleus membrane {ECO:0000269|PubMed:23973298}. Note=Colocalizes with peroxisome, cytoplasmic vesicles and/or organelles. Nucleus membrane localization is dependent of the WIT2 association. {ECO:0000269|PubMed:17288617, ECO:0000269|PubMed:17500056}.
Interaction partners:
- WPP domain-interacting tail-anchored protein 1
- WPP domain-interacting tail-anchored protein 2
- SUN domain-containing protein 2
- Protein SINE1
- SUN domain-containing protein 1
- Protein CROWDED NUCLEI 1
Sequence:
MRNCLPMELNLRKGDKVWVEDKDLAWIAADVLDSFDNKLHVETSTGKKVFVSPEKLFRRDPDDEEHNGVDDMTKLTYLHEAGVLYNLQRRYALNDIYTYTGSILIAVNPFKKLPHLYNGHMMEQYMGAPFGELSPHVFAVSDVAYRAMIDDSRSQSILVSGESGAGKTETTKLIMQYLTFVGGRATDDDRSVEQQVLESNPLLEAFGNAKTVRNDNSSRFGKFVEIQFDTNGRISGAAIRTYLLERSRVVRITDPERNYHCFYQLCASGNDAEKYKLSNPRQFHYLNQSKTYELEGVSSAEEYKNTRRAMDIVGISQDEQEGIFRTLAAILHLGNVEFSSGREHDSSVVKDPESRHHLQMAADLFKCDANLLLASLCTRSILTREGIIIKALDPNAAVTSRDTLAKTVYAHLFDWLVDKINKSVGQDPESRFQIGVLDIYGFECFKNNSFEQFCINFANEKLQQHFNEHVFKMEQDEYRKEEINWSYIEFIDNQDVLDLIEKKPIGVIALLDEACMFPRSTHESFSMKLFQNFRFHPRLEKPKFSETDFTLSHYAGKVTYQTEAFLDKNRDYTIVEHCNLLSSSKCPFVAGIFPSAPEESTRSSYKFSSVSSRFKQQLQALMETLSKTEPHYVRCVKPNSLNRPQKFESLSVLHQLRCGGVLEAVRISLAGYPTRRNYSDFVDRFGLLAPEFMDESNDEQALTEKILSKLGLGNYQLGRTKVFLRAGQIGILDSRRAEVLDASARLIQRRLRTFVTHQNFISARASAISIQAYCRGCLSRNAYATRRNAAAAVLVQKHVRRWLSRCAFVKLVSAAIVLQSCIRADSTRLKFSHQKEHRAASLIQAHWRIHKFRSAFRHRQSSIIAIQCRWRQKLAKREFRKLKQVANEAGALRLAKTKLEKRLEDLEWRLQLEKRLRTSGEEAKSSEISKLQKTLESFSLKLDAARLATINECNKNAVLEKQLDISMKEKSAVERELNGMVELKKDNALLKNSMNSLEKKNRVLEKELLNAKTNCNNTLQKLKEAEKRCSELQTSVQSLEEKLSHLENENQVLMQKTLITSPERIGQILGEKHSSAVVPAQNDRRSVFETPTPSKHIMPFSHSLSESRRSKLTAERNLENYELLSRCIKENLGFNDDKPLAACVIYKCLLHWRAFESESTAIFNIIIEGINEALKGGDENGVLPYWLSNASALLCLLQRNLRSNSFLNASAQRSGRAAYGVKSPFKLHGPDDGASHIEARYPALLFKQQLTACVEKIYGLIRDNLKKELSPLLGSCIQAPKASRGIAGKSRSPGGVPQQSPSSQWESILKFLDSLMSRLRENHVPSFFIRKLVTQVFSFINLSLFNSLLLRRECCTFSNGEYVKSGISELEKWIANAKEEFAGTSWHELNYIRQAVGFLVIHQKKKKSLDEIRQDLCPVLTIRQIYRISTMYWDDKYGTQSVSSEVVSQMRVLVDKDNQKQTSNSFLLDDDMSIPFSAEDIDKAIPVLDPSEIEPPKFVSEYTCAQSLVKKPSIASTSKQII
Protein: 3-(3-hydroxy-phenyl)propionate transporter (3HPP transporter) (3-(3-hydroxy-phenyl)propionate:H(+) symporter) (3HPP:H(+) symporter) (P77589)
Organism: Escherichia coli (strain K12)
Function: Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23934492}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein YaiL
- Uncharacterized MFS-type transporter YfcJ
- Inner membrane metabolite transport protein YdjE
- Putative metabolite transport protein YaaU
Sequence:
MSTRTPSSSSSRLMLTIGLCFLVALMEGLDLQAAGIAAGGIAQAFALDKMQMGWIFSAGILGLLPGALVGGMLADRYGRKRILIGSVALFGLFSLATAIAWDFPSLVFARLMTGVGLGAALPNLIALTSEAAGPRFRGTAVSLMYCGVPIGAALAATLGFAGANLAWQTVFWVGGVVPLILVPLLMRWLPESAVFAGEKQSAPPLRALFAPETATATLLLWLCYFFTLLVVYMLINWLPLLLVEQGFQPSQAAGVMFALQMGAASGTLMLGALMDKLRPVTMSLLIYSGMLASLLALGTVSSFNGMLLAGFVAGLFATGGQSVLYALAPLFYSSQIRATGVGTAVAVGRLGAMSGPLLAGKMLALGTGTVGVMAASAPGILVAGLAVFILMSRRSRIQPCADA
Protein: Endothelin-1 (ET-1) (Preproendothelin-1) (PPET1) [Cleaved into: Big endothelin-1] (P22387)
Organism: Mus musculus (Mouse)
Function: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor.
Subcellular location: Secreted.
Interaction partners:
- Endothelin receptor type B
- Endothelin-1 receptor
- Matrix metalloproteinase-9
- Endothelin-converting enzyme 1
- Endothelin-3
- 72 kDa type IV collagenase
- Endothelin-2
- B2 bradykinin receptor
- B1 bradykinin receptor
- Angiotensinogen
Sequence:
MDYFPVIFSLLFVTFQGAPETAVLGAELSTGAENGVQSPPPSTPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGGSSRSKRSLKDLLPNKATDQAVRCQCAHQKDKKCWNFCQAGKELRAQSTMQKSLKDSKKGKPCSKLGKKCIYQQLVEGRKLRRLEAISNSIKASFRVAKLKAELYRDQKLTHNRAH
Protein: Serine/threonine protein phosphatase 2A regulatory subunit (Q6DFL3)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
- Ppp2r1a-prov protein
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- Ppp2r1b protein
- Uncharacterized protein.
- Uncharacterized protein.
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
- REC8 meiotic recombination protein L homeolog isoform X1
- LOC398610 protein
- Uncharacterized protein.
Sequence:
MSAISAAEKVDGFTRKSVRKAQRQRRSQGSSQFRGQGPPVELSPLPPLKDATSNEQQDLFCQKLQQCCVLFDFIDSISDLKSKEIKRATLNELVEYVATNRGILVEPAYPDIIKMICSNIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKRFVDQKFVQQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETDHFNGVAELLEILGSIINGFALPLKSEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTALTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIQEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKVLPIMFGSLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDELTSSYKAERQREKKKEVEREELWRRLDELLLKKSLSDKQNPALCVQNIQNNASAK
Protein: Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen homolog) (Pteroylpoly-gamma-glutamate carboxypeptidase) (P70627)
Organism: Rattus norvegicus (Rat)
Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q04609}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q04609}.
Interaction partners:
- Aspartoacylase
- N-acetylaspartate synthetase
- Ribosomal modification protein rimK-like family member B.
- N-acetylated-alpha-linked acidic dipeptidase 2
Sequence:
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
Protein: Serine/threonine-protein kinase ZRK3 (EC 2.7.11.1) (Q8VZF4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for RPP13L4/ZAR1 recognition of the Pseudomonas syringae type III effector (T3E) HopF2a.
Interaction partners:
Sequence:
MESMVKKLKQNLRTGSWKKKEKSMKKERWFLENGSIFLKELIVDCNGKSIPIRSFTSSQIRKATKNFDLSCFVAEEGFYIWYKGVIEDRSYMIKRFSEYKVTDYRVSEVYKDIVLSARMSNHNNFLKLLGCCLEFPFPVLVFEFAEHGVLNYRGGITVNGEESLLPLSLRLKIGKEIANALAYLHMAFPKIIIYRDVKPLHVFLDNNWTAKLSDLSFSISLEEGKSQIEAEDVLGTYGYLDPLYFATRIVTEYTDVYSFGVFLMVVITGISVYFTGSDGYPVGILGYMKGLAENGKLNEIVYPMIMKEMTSAQRLQVEACVLLALRCCEERVEDRPKMIQVAKELKRIEHHVLRS
Protein: Cilia- and flagella-associated protein 184 (Q2M329)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium {ECO:0000250|UniProtKB:I7M6D6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}. Note=Localizes at cilium but not at the ciliary tips. {ECO:0000250|UniProtKB:I7M6D6}.
Interaction partners:
- Cilia-and flagella-associated protein 96
Sequence:
MDVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQKIREAKAFLPS
Protein: NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Q6VNS1)
Organism: Mus musculus (Mouse)
Function: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Neurotrophin-3
- Receptor-type tyrosine-protein phosphatase S
- Neurotrophin-4
- Beta-nerve growth factor
- Neurotrophic factor BDNF precursor form
- SHC-transforming protein 1
- Tumor necrosis factor receptor superfamily member 16
- Growth factor receptor-bound protein 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- SHC-transforming protein 3
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Protein: 5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2) (Q9NPB1)
Organism: Homo sapiens (Human)
Function: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10899995}.
Interaction partners:
- Thymidine phosphorylase
- Deoxyguanosine kinase, mitochondrial
- Cytosolic 5'-nucleotidase 3A
- GTP:AMP phosphotransferase AK3, mitochondrial
- UMP-CMP kinase 2, mitochondrial
- Thymidylate kinase
- Cytosolic 5'-nucleotidase 1A
- Purine nucleoside phosphorylase
- Cytosolic 5'-nucleotidase 1B
- Thymidine kinase 2, mitochondrial
Sequence:
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC
Protein: Vesicle-associated membrane protein 725 (AtVAMP725) (O48850)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}. Early endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
Interaction partners:
- Putative SNAP25 homologous protein SNAP30
- Syntaxin-23
- SNAP25 homologous protein SNAP29
- Syntaxin-124
- Syntaxin-52
- Bet1-like SNARE 1-1
- Syntaxin-112
- Putative syntaxin-131
- Syntaxin-125
- Syntaxin-31
Sequence:
MDRSVVPISLAPFQFLLVFWIFLTSVHTNPNKQQKTVVSLSLWWNSKNRIRGCVWFFFLLRVTRTMGQQNLIYSFVARGTVILVEYTEFKGNFTAVAAQCLQKLPSSNNKFTYNCDGHTFNYLVENGFTYCVVAVESVGRQIPMAFLERVKEDFNKRYGGGKATTAQANSLNREFGSKLKEHMQYCVDHPDEISKLAKVKAQVTEVKGVMMENIEKVLDRGEKIELLVDKTENLRSQAQDFRTQGTKIRRKMWFENMKIKLIVLGIIITLILIIILSVCGGFKCT
Protein: Arrestin-like N-terminal domain-containing protein (Q383N2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKTHRAAKHVTAHRILLERLSLQPGEVLRGIVEVWVDAPLGYSVLEVVLLGQEFTRLKSSFGKILGKDAAKATYYRQRVVVAGCPGENSQVSVVSEGGGNPEGANSDEWSDFNRSPSVSDVELAGIQSSGLMPGTYTFPFKVRLPSALPPTHEYHIRGSASRLKYTVTSTLLSRGRLLSTTDAPFSVKALPLDESRWMNAYLKTVPMFDGNVLLVSDAASGTEEDRWASLSGLQGTNCICMNHNMPLYAPNECSGSSDSVTDAGGLLTTTPFGAPHPASMDPLRSQLVKPSVNNWLDGASGVNTNEDATEDQKSGHGTEDALQPRASANESEQGMSVFQQADSCSGNKRGTHRGGDDSKGGGQAAAPGASDAQNNVDAAACLNQLVQRVRQDARWEHRLEVPIEGLFGRGSVTITLSFGRVVFTGGTTVRFHGLVDNERGLSNVLMINFSLVTHYQMNSLIETRHTRNVISECSLRQVVKRGEAARIPLCTLEVPQNTSPTAVTSNCSCRTFLDVEVFSMHGPGTRSGSARTELLVVDSLARDEKSSDRKGRWSNYFQCYDPLRGQSRIDIVSSYVLSGKINVIKKDACNGNGELLQPPEKPSRYCKTWKHTFRPQLDFVNATYYPDESSGHNSRGINPLQSLYYTEGSLTE
Protein: Golgi-associated RAB2B interactor protein 3 (Protein FAM71B) (Q5STT6)
Organism: Mus musculus (Mouse)
Function: May be involved in RNA biogenesis.
Subcellular location: Golgi apparatus {ECO:0000305|PubMed:18256213}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q8TC56}.
Interaction partners:
- Sperm-associated microtubule inner protein 5
- Ciliary microtubule inner protein 6
- Actin-like 11
Sequence:
MPGMKRTMSSECLLPYYTAHSYRSMGVFNTSMGNLQRQLYKGGEYDIFKYAPMFESDFIQISKRGEVIDVHNRVRMVTVCIASTSPVLPLPDVMLLARPAKVCEEHARRARFIKGKGCKPSKTLELTRLLPLKFVKISVHDHEKQQLRLKLATGRTFYLQLCPSSDAREDLFCYWEKLVYLLRPPMTNCISNSTLPTGETSVDTKSTLVSEIRGEGDQNSRPQSSPTVSEATSAAFAGGERTQPAAAAAVTPVSAKARAAGTAGAAAGTAGAAAGTAGPAAGPAAGTAGPAAGTAGAAAGTAGAAAGTAGATAGTAGATAGMAGATAGTAAETAGTAAETAGAARAAGGPMAAAVAAPSAGMTKAETATSPTSGVISLAATTTKPPGSGQVAAAMIGSAAKDQVGGESSKAMALAANITLENVDVALAGAANSISESPPAGGDASGSPDTGLNVAFAGSIKTKSPAEDKPEAPLVSTLQSEGYMCERDGSQKVSQTSSEAKEKRERREKDRTSSRKSSHHRRTGMSRHSSKDKSRKTSSYRSVSGKTREDKGKGHGRLRGKRHSSSHKSESRTGHKTRKNRSPAGLGSVSKRATKITSFFRSFLVRPTPKAGDTSCDRGGVDIVTKLVEKKQDIEAVMEKSKDSEFKDTVISETMEKIILETKSI
Protein: G protein subunit beta (A0A1D8PH43)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit gamma
- Cst5p
- Alpha-factor pheromone receptor
- Serine/threonine-protein kinase CST20
- Cyclin-dependent protein serine/threonine kinase inhibiting protein
- GTPase-activating protein
- Guanine nucleotide-binding protein subunit alpha
- Serine/threonine-protein kinase CLA4
- Rho family guanine nucleotide exchange factor
Sequence:
MSDYLAQSLIQSPSSVSQQEQQSLLSSITGQIDTARNEAKVLYTEILSVKRRTQDATIQAISQNVSQIPKNSCNLTLYNTLRGHQNKIAKLCWSSDSSKILSASQDGFMIIWDAVTGFKKHAIQLSNPWVLTCSYSPNEKLVASAGLDNNCTIYKIKPDTSNFPVTEERNGTYQMQGNFYQSIQSIFKGHTAYISECEFIGSNSIVTASGDMTCALWDLTKGTKSRDFVEHSGDVLCLSTFPQNILSANLFVSGSSDGSAKIWDLRSPTPTQSFGISNSDVNSVKVFPDGNAFATGSDDGSIRLFDLRSDCELGHYSLSSELRNKQNLLHLTIPSPADERYMKRFGNTTAQTYDEQSTSLLHSNGSSSGNIDQYSVNSLQSVIENQGVFSLDFGKSGRFLYSCYSEYGCVVWDTLKSEIVGIIGSEHLNKINQVSVSPDGVALATGSWDATIKVWSV
Protein: At1g72880 (Survival protein SurE-like phosphatase/nucleotidase) (Q84MD7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Inosine-5'-monophosphate dehydrogenase 1
- AMP deaminase
- mRNA-decapping enzyme-like protein
- Hypoxanthine phosphoribosyltransferase
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- mRNA-decapping enzyme subunit 2
- Apyrase 2
- Apyrase 1
- Probable apyrase 6
- Uridine nucleosidase 1
Sequence:
MTSKNNGLSAALVSNLQDVLSKRKVGNEEKVGSDGSAEEAPSTSDSVDVASVEEEIDDSRPIVLVTNGDGIDSPGLVSLVEALVLEGLYNVHVCAPQTDKSASAHSTTPGETIAVSSVKLKGATAFEVSGTPVDCISLGLSGALFAWSKPILVISGINQGSSCGHQMFYSGAVAGGREALISGVPSLSISLNWKKNESQESHFKDAVGVCLPLINATIRDIAKGVFPKDCSLNIEIPTSPSSNKGFKVTKQSMWRQYPSWQAVSANRHPGAGNFMSNQQSLGAQLAQLGRDASAAGAARRFTTQKKSIVEIESVGVAGKTDTRVKKFFRLEFLAKEQEHTDEDLDVKALEDGFVSVTPFSLLPKTDSETQAAASEWISKALNSDQ
Protein: AT11783p (Glutamate carrier 2, isoform D) (A8WHE0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MYRGSAVNIVLITPEKAIKLTANDFFRYHLASDDGVIPLSRATLAGGLAGLFQIVVTTPMELLKIQMQDAGRVAAADRAAGREVKTITALGLTKTLLRERGIFGLYKGVGATGVRDITFSMVYFPLMAWINDQGPRKSDGSGEAVFYWSLIAGLLSGMTSAFMVTPFDVVKTRLQADGEKKFKGIMDCVNRTLKEEGISAFFKGGLCRIMVLAPLFGIAQMFYFLGVGEKILGIERTKSV
Protein: 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (A5VZY6)
Organism: Pseudomonas putida (strain ATCC 700007 / DSM 6899 / JCM 31910 / BCRC 17059 / LMG 24140 / F1)
Function: Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with 200-fold lower efficiency.
Interaction partners:
Sequence:
MKQIHVIDSHTGGEPTRLVMKGFPQLHGRSMAEQRDELRELHDRWRRACLLEPRGNDVLVGALYCPPVSADATCGVIFFNNAGYLNMCGHGTIGLVASLQHLGLIAPGVHKIDTPVGQVSATLHEDGAITVANVPSYRYRQHVAVNVPGHGVVHGDIAWGGNWFFLVAEHGQRIELDNREVLTEYTWAMLKALEAQGITGENGAPIDHVELFADDPNADSRNFVMCPGKAYDRSPCGTGTSAKLACLAADGTLAEGQTWVQASITGSQFHGRYERDGERIRPFITGRAHMTADSTLLIDEQDPFAWGI
Protein: Ribosomal RNA processing protein 36 homolog (Q96EU6)
Organism: Homo sapiens (Human)
Function: Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:20038530}. Note=Concentrated in the fibrillar region of the nucleolus.
Interaction partners:
- Something about silencing protein 10
- Activator of basal transcription 1
- U3 small nucleolar RNA-interacting protein 2
- U3 small nucleolar RNA-associated protein 25 homolog
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 6 homolog
- U3 small nucleolar RNA-associated protein 18 homolog
- Probable ATP-dependent RNA helicase DDX10
- Nucleolar MIF4G domain-containing protein 1
- Bystin
Sequence:
MPGANYRAGAGAGAGARRPRGARDREEDGGGLEPAAVARDLLRGTSNMSFEELLELQSQVGTKTYKQLVAGNSPKKQASRPPIQNACVADKHRPLEMSAKIRVPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLNDIRAKEKELVKKQLKKHLSGEEHEKLQQLLQRMEQQEMAQQERKQQQELHLALKQERRAQAQQGHRPYFLKKSEQRQLALAEKFKELKRSKKLENFLSRKRRRNAGKDRRHLPLSKE
Protein: Transcriptional regulatory protein DcuR (P0AD01)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor histidine kinase DcuS
- Sensor histidine kinase DpiB
- Anaerobic C4-dicarboxylate transporter DcuB
- Aerobic C4-dicarboxylate transport protein
- Transcriptional regulatory protein BtsR
Sequence:
MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLTPQTLRTLCQWIDAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRIQAEHYSLLKQYCQ
Protein: Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36) (Q8IYA8)
Organism: Homo sapiens (Human)
Function: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
Subcellular location: Chromosome {ECO:0000250|UniProtKB:Q6PDM4}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. {ECO:0000250|UniProtKB:Q6PDM4}.
Interaction partners:
- Meiotic recombination protein REC114
- HORMA domain-containing protein 1
- Meiosis-specific protein MEI4
- CXXC-type zinc finger protein 1
- Ankyrin repeat domain-containing protein 31
- Meiosis inhibitor protein 1
- Meiotic recombination protein SPO11
- Type 2 DNA topoisomerase 6 subunit B-like
- Histone-lysine N-methyltransferase PRDM9
Sequence:
MNFNVWNIKEMLSIPSGSGNKKSSNWNNNQNDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRHSKQSQQNYLEGEPSIFTKYQTKPQLFGGDIKDGGLFPPPLSVGKSKGLLEQFEEKKKRAKDKCDSETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLVFEAVQDKGNMEQAILEMKKRFEARQGEFIEMKSNLKHLEVLVAQQSQEFQQLCEQLGQLNVPSVLAELKRLISVPPVKDSASQTSPPLAQSLNLTRQEKYTSEKPVLWQAQALPAAWNPGMGSLQPGEFDVWGEGAKNDDLQEEAALPAFGSHERNRHVKDKVVQTNCKNWAVTKTGAKNHGSSVPGHKIPSDRDLVSQGASQLTSLEINFSTSIKNACQKYQAQSMFLCDPREHLVIKQKDGTVEMRGKDKKQQPRKAHRAHRGRLIASKQKQIPIQTCKFNSKYQSPQPAISVPQSPFLGQQEPRAQPLHLQCPRSPRKPVCPILGGTVMPNKTVRAVQGRLLQLSRCSSQDNWLLSSSSQGDHQMSWFSDLNLGCSETPLCKEAGKNLLYDLGFDSSDDDGF
Protein: 4,5-DOPA dioxygenase extradiol (EC 1.13.11.29) (Q70FG7)
Organism: Beta vulgaris (Sugar beet)
Function: Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. Produces mainly (S)-betalamic acid.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MGSEDNIKETFFISHGTPMMAIDDSKPSKKFLESWREKIFSKKPKAILVISAHWETDQPSVNVVDINDTIYDFRGFPARLYQFKYSAPGSPELANRIQDLLAGSGFKSVNTDKKRGLDHGAWVPLMLMYPEADIPVCQLSVQSHLDGTHHYKLGQALAPLKDEGVLIIGSGSATHPSNGTPPCSDGVAPWAAAFDSWLETALTNGSYEEVNKYETKAPNWKLAHPWPEHFYPLHVAMGAAGENSKAELIHNSWDGGIMSYGSYKFTST
Protein: Not3 domain-containing protein (G5EFX8)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR005290}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
Interaction partners:
- CCR4-NOT transcription complex subunit let-711
- CCR4-NOT transcription complex subunit 9
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 11
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- CCR4-NOT transcription complex subunit 4
- poly
- Protein PAT1 homolog 1
- ATP-dependent RNA helicase cgh-1
Sequence:
MAEKRKLLAEIDKCFKKIDEGVELFEETMEKMHEANSDNQRDKYQDDLKKEIKKLQRLRDQVKNWQNASEIKDKDKLNSYRKLIEQRMEQFKDVERENKTKPHSKLGLSAEEKLDPKEKEKAETMDWIQHQIRSLNEEVDRTEMQLESLSNTDTGKGKRGKKEDAKTKNEREKRVEGLKHHLERINFHIEKLEICMRMISNESLNAKMVLETLKEPIETYVEMMNEEDSEEADNYDPDDAYDELNLEKLCQQIGGVNVASVDDEHRENGHELGIDTAESGAVSGSRHTSGENGQPPSPAGRRIVPLSMPSPHAVTPELKRLASKDSNVDRPRTPPVTPASAAPPPPGIPYNSVAAGRSTTTPVPSTPISANSPAPSLAQAAPIAAASPVFPPAAAAASKPVLAQSVSEMPQKKESITSTTSRGSAAAPATTTTTTTTTTSSEPAEVPLVVQQTVSETFVNGVDSPAAATRLTQQERQQQLQQQHHHQSTIIPTTPTTTTTSSSMLGGMMSTDDPAAALQAALNMAAASQQAVATGPKRAHIPAWLGASPLGRTSMTQEFDGQLAALELACAKATFPLDSEKPRNYLSKVSFPVPSWYGQTAPNTSDSLEYYLRLAPDTLFFIFYYMEGTRAQLLAAKALKKLSWRFHTKYLTWFQRHEEPKQITDDYEQGTYVYFDFEKWSQRKKESFTFEYKFLEDKEFD