wanglab/gogpt-training-data huggingface dataset:
Protein: Galactose oxidase (Q38B15)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQRVGSEREGRRGSYISSHSNEADAAKAESGHLTAFRAATLPEPKTWLQRTGHTIVVYKSNMFLFGGTGPNSTYSSSIFCNEKMTLQWKECRGVGVVPTGRANHTSVLVENKMFVFGGHRELEVFDELYIVNLDSMRWEKVSYEHVQGPGPVFSHAAVFIPPTQAMIVIGGFHQRKHNTYIAHSFDIRSRTWTGIHGPSSVNPLHLQLVNAVYHHQSISLIVVGMSMKSCGSPRFADTPSIFAMNIYSCFWTELTTAVSPSSPIAFRMPLVWEHFLEEHISVGGIYDERRQEFYFPIMMAPIEGALVHQHFDRRPSSATSVTGQQSSRSILRSASTVREPEGDGKVKFDGCAVFRLQLRTMTWSLTPVVIPKRVVNSLLAYRAEVRSGKGGKRASSRMRRRATNDKKASSVTALFSSNGVSVYQRKYAYACISSSALRKSGGDQKHILMHGGLFDECIALLLAPVFHDNPMDSASLDSVSLLNASVYSTLTVLTTDNVNSGKSAYEFSRSDYSDAETKATEAASSSTGGNGSMPPPSTEENRDVSVTSLHLRRRSSDVHNSRAFPSPRVVDSKDHFALLYHPNNAMNKPQHLPDANYPVAVLRSEKEVRSWAEDFYQDTRDKVIENVLALREKDKKERKQFSRSRKAQKSSSVGGSDEDVFTDDDSSESKGLSDGKVVEKAQSPRQGRGLFGIIRPNVPVIPRDFFYEKNLDVFALREHWCYDLQHREKKQNTSQHSRIDAISRVNMKVRRLPENNRLPLEVFGQASVENISGAASLAAYLLMEAALARCEDDTAKSRRQRTLIRWRYLRVMVLNGEASSIMYFVNAEANRGSGVNVSTTSKVVLGPELYVKGPNPKKVPTRPVPYTIPQLPSITLRAAEVTPSGYTLYRYAPVPGSGGRRSKNH
Protein: Serum resistance protein DsrA (Q9K2H6)
Organism: Haemophilus ducreyi
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}. Cell surface {ECO:0000256|ARBA:ARBA00004241}.
Interaction partners:
Sequence:
MKIKCLVAVVGLACSTITTMAQQPPKFAGVSSLYSYEYDYGKGKWTWSNEGGFDIKVPGIKMKPKEWISKQATYLELQHYMPYTPVLVTYAPGVSPSPILLYPMSDPDQLGINRQQLKLNLYSYFNDLRHDFKLKVLDARISKNKQNIDTISKYLLELGTYLDDSYRMMEQNTHNINKLSKELQTGLANQSALSMLVQPNGVGKTSVSAAVGGYRDKTALAIGVGSRITDRFTAKAGVAFNTYNGGMSYGASVGYEF
Protein: Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) (P08758)
Organism: Homo sapiens (Human)
Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Interaction partners:
- Actin, cytoplasmic 1
- Glyceraldehyde-3-phosphate dehydrogenase
- Caspase-3
- Apoptosis regulator Bcl-2
- Cholecystokinin
- Probable oxidoreductase PXDNL
- Peroxidasin homolog
- Caspase-9
- Poly [ADP-ribose] polymerase 1
- Tissue factor
Sequence:
MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD
Protein: Heparanase (EC 3.2.1.166) (Endo-glucoronidase) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] (Q6YGZ1)
Organism: Mus musculus (Mouse)
Function: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Subcellular location: Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:15793281}. Nucleus {ECO:0000269|PubMed:15793281}. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts. {ECO:0000250}.
Interaction partners:
- Syndecan-1
- Inactive heparanase-2
- Iduronate 2-sulfatase
- Hepatocyte growth factor-regulated tyrosine kinase substrate
Sequence:
MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI
Protein: Uncharacterized protein (Q38B25)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MATILTTSNVHNIPAVCRIPEKGTATLVSPGMLLTSTHVVGTADACASLTAIFFEGTKKKPVEVKLLPQKYFFAAAYPEYMDYCLVACEEAGLLNVVPVTIPLTKDQWAPVTEGDIILVVQHPAESSDSGKADPEVGDIAPAAGSADPPLVMKRFVEVLRHRDDLFYLKTTRDVRTAGCPAFNDRGQLIGLQSQVRHPRTGIVNHVVSITAIVKHLFANKQLWSINRNQTFEEVWNTWYVKNDITRILSITANFKSRAITRETILKLCEHAAQREILNTLVREGGAQAILNALDIFIDDEEVVFACIKALWNISFSEELIRLCLGGGKSLGMILDAMEKFPKNEQIAEHATLFLHNICSGNDKLDFERDVEERALTLVHSTLRTFKGTVMLQKFGFAFFNSLIATNLRNAEILVGQGVIAHLVRLAQERKDNVLLMEVVMRFLGFIAQNPRAVNMYVTSRDVGMGGGSKGVSVITGLLVDIMLKHKDVDRILLDGSQALWGFGNDVACRAVILQHPRAFEALRISLPAVISHSKVL
Protein: Peptidyl-prolyl cis-trans isomerase 5 (PPIase 5) (EC 5.2.1.8) (Cyclophilin-5) (Rotamase 5) (P52013)
Organism: Caenorhabditis elegans
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12215411}.
Interaction partners:
- rRNA 2'-O-methyltransferase fibrillarin
- U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 5
- Probable NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- WD_REPEATS_REGION domain-containing protein
- Periodic tryptophan protein 2 homolog
- Probable NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- WD_REPEATS_REGION domain-containing protein
- U3 small nucleolar RNA-associated protein 15 homolog
Sequence:
MKSLLVVAAVLAVGALAQGDDAKGPKVTDKVYFDMEIGGKPIGRIVIGLFGKTVPKTATNFIELAKKPKGEGYPGSKFHRVIADFMIQGGDFTRGDGTGGRSIYGEKFADENFKLKHYGAGWLSMANAGADTNGSQFFITTVKTPWLDGRHVVFGKILEGMDVVRKIEQTEKLPGDRPKQDVIIAASGHIAVDTPFSVEREAVV
Protein: Interacting with cytoskeleton protein 1 (Q04329)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for viability of cells lacking mtDNA.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YGR050C
- Uncharacterized vacuolar protein YLR297W
Sequence:
MSSNYATPLDDEVFPLSFANYQFTEHVSLGEHYSLNTSEDAKYNNLNGPFVVPRDTGKFDLNTSSASDETVFSLDNPQENNYKHQAMNNVQDCRMAVAAKTTQSCDKLTDLYANAAQQNYRLWLSSF
Protein: AAA+ ATPase domain-containing protein (P71922)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- VWA domain-containing protein
- Gamma-glutamyl phosphate reductase
- VWFA domain-containing protein
Sequence:
MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELARAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQRPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTSNATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKKVPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q23975)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MLSALRLIFLGALLGASVCASPIEFVMDTSLNGSRSDPATATHPGKWPPTTKAPALRAPAGTAGHAYQSPSSSLAADNRSHDNNNASAVSMLLPQDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYSCMVVKYNMQRSKPSECLTSNERFDTYRIDCCKSDFCNKNENMKRIFETDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDIIEMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVKN
Protein: Uncharacterized protein (Q5AVD7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- non-specific serine/threonine protein kinase
- Pheromone
- Pheromone receptor PREB
Sequence:
MDAPKTSPSAEAVVMQALSAIAVIITSSTLALHWKNRNFPAAIMMGWLILLNLFNVINAFIWPTDDVDNWWDGAGLCDIEVKMLISSYVAIPGSLVCIFRSLACVLDTSRATLVQTKRQRWITRSVEVLFCVLVPLLAAATHLIYQGNRYFIFAVSGCVSGLDRSWVSFALGYLWPLVAYMVYVQVKLSMPWHPFSWSLLHGPGSSWRVIERIPTGGAVYFDRWIPVASAYTAFAFFGTGRDASRMYRSFLRPFGLDCCFSPMENKTSGSFPHTSGSAGSRAHLIPGRGKAQSDLYHYARKNSIDYTSSSRASSKDEDLEKGIPVSSVTENQVVSKKGWLKTGFAWLGNQFPFSLSPSACREKIRSRSTPHLVVPASSNTVCTNAWAGSRQSRGSIDFDDSSESLSSKMDFIRVKQVIRQERETHV
Protein: Early nodulin-like protein 2 (AtENODL2) (Phytocyanin-like protein ENODL2) (Q9T076)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12805588, ECO:0000269|PubMed:14517339}.
Interaction partners:
- At3g13230
- At2g45350/F14N22.7
- Expansin-A21
- Zinc finger
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- Uncharacterized protein
- Phosphoglycerate mutase family protein
- At3g15680
- ALC-interacting protein 1
- Glycine-rich protein
Sequence:
MTFLKMKSLSFFFTILLSLSTLFTISNARKFNVGGSGAWVTNPPENYESWSGKNRFLVHDTLYFSYAKGADSVLEVNKADYDACNTKNPIKRVDDGDSEISLDRYGPFYFISGNEDNCKKGQKLNVVVISARIPSTAQSPHAAAPGSSTPGSMTPPGGAHSPKSSSPVSPTTSPPGSTTPPGGAHSPKSSSAVSPATSPPGSMAPKSGSPVSPTTSPPAPPKSTSPVSPSSAPMTSPPAPMAPKSSSTIPPSSAPMTSPPGSMAPKSSSPVSNSPTVSPSLAPGGSTSSSPSDSPSGSAMGPSGDGPSAAGDISTPAGAPGQKKSSANGMTVMSITTVLSLVLTIFLSA
Protein: 60S ribosomal protein L23a, putative (Q57ZH1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- Ribosomal protein
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L19, putative
- 60S ribosomal subunit protein L31, putative
- Ribosomal protein L37
- 60S ribosomal protein L35A, putative
- 60S ribosomal protein L27a
Sequence:
MMISFAQGSGVLVWGEWGSQLHRLQTTVIMISYPFFHYWISPPVFCRLLSLRLTRTMPAKAASAAASKKNSAPKSAVSKKVAKKGAPAAAAKPTKVVKVTKRKAYTRPQFRRPHTYRRPATVKPSSNVSAIKNKWDAFRIIRYPLTTDKAMKKIEENNTLTFIVDSRANKTEIKKAIRKLYQVKTVKVNTLIRPDGLKKAYIRLSASYDALDTANKMGLV
Protein: MAU2 chromatid cohesion factor homolog (Sister chromatid cohesion protein 4) (P40090)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes. Binds to the nucleosome-free promoter regions of ribosomal protein genes and tRNA genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:10882066, ECO:0000269|PubMed:25173104}. Note=Associates with chromatin. {ECO:0000269|PubMed:10882066, ECO:0000269|PubMed:25173104}.
Interaction partners:
- Sister chromatid cohesion protein 2
- Inner kinetochore subunit CTF19
- Structural maintenance of chromosomes protein 3
- Sister chromatid cohesion protein 1
- N-acetyltransferase ECO1
- Sister chromatid cohesion protein PDS5
- Cohesin subunit SCC3
- Protein RAD61
- Structural maintenance of chromosomes protein 1
- Inner kinetochore subunit CHL4
Sequence:
MENLGDKLSISQVYHLAQEYRDHAYSIANKIGSEEGLKQYYGLMNMSIQMFQLLKTKCTLSVLEDSKVTFEMVELLIQETYNFDLAELYISSLKERLQTHQSDTDLVEEIMRCEFLLLHDLPLMRDSKFHYKIALRNCNELVQYMVNLQDELYQNWASVFQYVGVMLCIKLKQHRRVKTSFHGLLSQCREKSQWKWFLNLCYVNYLLNERFPIPEDALQELRSTELHTVGPELYAWKLALEMVIQLCKDGNITDHLNEFKNFFDTNKQSLVTNEGKGCVIKIMPRIALKVELPMIFHYKELKNILLLLQSVSYIVNCYDEKGNFSRKFLPKVYSTTQKLIKNIAAGGVSMNELDSRIQTYKSILEFCEFYKVWEQTLLKGAVVTTESPKLGPSPGYVRLLQAMKVQFEGGGAVEEYTRLAQSGGTSSEVKMISLLNCYTVQAARVSRCSGDKQGELVEQCNKVWLQVEKLLQETDLQFNPIWECTVTILWLFSHFEPFSWNPLPCSDKQRAEYVSKLREFYSSNKFVAGEAVADNRFKLKKALLLQILVNYLGGRMLEHDLGEIYAISAKCFDMCRQQGGMRKVQYVIGIWHLMNCTVAMRGKDVALTNAKLEALVKQITSVKQ
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8I3C7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Protein phosphatase PPM5, putative
Sequence:
MSFYNCSDYNFNKDQLCNKNVYSEIKIIAPFHKNVEESKKINYNLKTWLSRCLIIAQTIILVYTYLFHLNVLSCNINSDSISCKGIIRNLSEPCKVNEKSHETFIDRVFYGTKKKKDGSNKNKKLFNWELCKYHISNRLGKAKEYSIGGVNYEKWDLYSIKNENYNESGGRNHEMFSTVISSKSGFRKKKVKLFIKKVPLNSWIELYNKMDIYHGEFLDGAENFVMEAMVSLFLNKYHPGITPKFYNLLYESENDYSELKGLNELMFCDIDIFKNELIKIRNRNKKGYVVMIWEFFGQNLKEFLHSEKENLVITKERKKILFECLKLINKLHKAGLTHLDISPENILIGENYEMRLCDFGKTTPLYVLNNIDEHNKGHLQRFRSYIPYVGKTKYAPPECWNLKKKYKELGIENPLVYLKTLKDYEYKDTLYFDVLAADIYMLGILFIWISSNRYLWGNFDMSQNSNFKKFVNSDMNFDLFPLTREWPEGLKYIIRKLLDYESRKSLDLNELIEHPWWSTDL
Protein: Sphingomyelinase (SMase) (EC 3.1.4.12) (P9WKQ1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the cleavage of sphingomyelin, a major lipid in eukaryotic cells, into ceramide and phosphocholine, which are then utilized by M.tuberculosis as carbon, nitrogen and phosphorus sources, respectively. Thus, enables M.tuberculosis to utilize sphingomyelin as a source of several essential nutrients for intracellular growth during infection. Furthermore, lyses erythrocytes and constitutes the main hemolytic factor of M.tuberculosis.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:26036301}; Multi-pass membrane protein {ECO:0000305|PubMed:26036301}.
Interaction partners:
- Outer membrane channel protein CpnT
- Probable cobalt/nickel-exporting P-type ATPase
- Conserved hypothetical proline and threonine rich protein
- Uncharacterized protein Rv3778c
- Probable hercynylcysteine sulfoxide lyase
- Probable cysteine desulfurase
- Uncharacterized protein Rv3403c
- Conserved protein
- Probable PhiRv1 phage protein
- Proline-rich 28 kDa antigen
Sequence:
MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR
Protein: Cysteine-rich and transmembrane domain-containing protein PCC1 (Protein PATHOGEN AND CIRCADIAN CONTROLLED 1) (Q94C26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates resistance against pathogens including oomycetes (e.g. Hyaloperonospora parasitica and Phytophthora brassicae) and fungi (e.g. Phytophthora brassicae). Controls the abscisic acid-mediated (ABA) signaling pathways. Regulator of the flowering time in response to stress (e.g. UV-C). Regulates polar lipid content; promotes phosphatidylinositol (PI) and 18:0 but prevents 18:2 and 18:3 polar lipids accumulation.
Subcellular location: Cell membrane {ECO:0000305|PubMed:19933165}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein ACCELERATED CELL DEATH 6
- carnosine N-methyltransferase
- Cysteine-rich/transmembrane domain A-like protein
- Protein LURP1
- Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 4
- Germin-like protein subfamily 1 member 19
Sequence:
MNQSAQNYFSVQKPSETSSGPYTSPPPIGYPTRDAVVGDPPAAAVETNSKGVNPEAIMSCFSTCMECIFCCGVCSSLCTSE
Protein: Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) (P41366)
Organism: Gallus gallus (Chicken)
Function: Exact function not known, component of the outer membrane of the vitelline layer of the egg. Seems to be able to synthesize N-acetylchito-oligosaccharides (n=14-15) from hexasaccharides of N-acetylglucosamine in a manner similar to the transferase activity of lysozyme.
Subcellular location: Secreted.
Interaction partners:
- Uncharacterized protein.
- Protein TENP
- Ovoinhibitor
- Gallinacin-11
- Guanylate cyclase 1 soluble subunit alpha 2
Sequence:
MKVLTPAALILLFFFYTVDARTREYTSVITVPNGGHWGKWGIRQFCHSGYANGFALKVEPSQFGRDDTALNGIRLRCLDGSVIESLVGKWGTWTSFLVCPTGYLVSFSLRSEKSQGGGDDTAANNIQFRCSDEAVLVGDGLSWGRFGPWSKRCKICGLQTKVESPQGLRDDTALNNVRFFCCK
Protein: NrdJb (Q9HT77)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Vitamin B12-dependent ribonucleotide reductase
- Ribonucleoside-diphosphate reductase subunit beta
- Ribonucleoside-diphosphate reductase
- UPF0301 protein AlgH
- Class III
- Class III
- Formate dehydrogenase-O, major subunit
- DUF7380 domain-containing protein
- Intermembrane phospholipid transport system permease protein MlaE
Sequence:
MSAVKITQKIKGFKVVNEAEEQALAAAAEAASVVQMDETLERPDTLIGATYKIKSPLFEHALYVTINDMVLNAGTAHEQRRPFEIFINSKNMDHFQWIVALTRIMSAVFRKGGDCTFLVEELKAVFDPRGGYLKKGGIYMPSIVAEIGGVLERHLTAIGLLRGPELDEEQRLFLAEKRAAYEAAQGTSKVEPGEGFPAGAQLCGKCNSMAVVQMDGCATCLNCGHSKCG
Protein: adenosine deaminase (EC 3.5.4.4) (Q8IQR3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- purine-nucleoside phosphorylase
- AT19257p
- Adenosine kinase
- Adenosine kinase
- Adenosine kinase
- 5'-Nucleotidase C-terminal domain-containing protein
Sequence:
MGDVEFQNVQEIRGTPQNAMRMIRLELDEEENRRQMSSSKYGGVCFHVAIAVMLCVMVLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIRQVDEEFYNLWRNYHSQPPPFLKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILIDLIYRDNLWVCVNLEQDFEDFRFSRYFPHIPPAEDYQCNWMLMSNFFQLESRLEFENRLRKTLTVRPEGYKSSSELARHLRRHQRIIHGLITFRPIWSEFIFTMLSDFYADGVHYVELRSSLPNMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENARLLKLHFPNFFAGFDLNTFGDECNLPLLENVTQLLRIGKNIDFYFHAGESRCPDSSRPDANLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDYPCFWNSAPLTDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEKNMAVSKWQCSWNRWVRNLVNSSGY
Protein: Smad nuclear-interacting protein 1 (Q8BIZ6)
Organism: Mus musculus (Mouse)
Function: Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TAD8}.
Interaction partners:
- RNA-binding motif protein, X-linked 2
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- BUD13 homolog
- Splicing factor 3B subunit 1
- SNW domain-containing protein 1
- PHD finger-like domain-containing protein 5A
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
- Splicing factor 3A subunit 3
- Spliceosome-associated protein CWC27 homolog
- Splicing factor 3A subunit 2
Sequence:
MKAGKSERERSGRRRHRSGDALTTVVVKQERLSPEPVAHRRPDAPAASLSPPAAEPGHSGHRGSRARSPAKKKSKSSGRRSKSPRTKRSQSPHYPMVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSERDRHRGHSRQGRSSDERPVSGQDRDRDSQNLQAQEEERDFHNARRREHRQQNESAGSEAQEVIPRPAGNRSKEVPVKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSELDRKEDEDDEEEEMVSDS
Protein: Protein unc-45 homolog A (Unc-45A) (Stromal membrane-associated protein 1) (SMAP-1) (Q99KD5)
Organism: Mus musculus (Mouse)
Function: May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominant in the perinuclear region. Little protein in the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
Sequence:
MTVSGPETPEPRPSDPGASSAEQLRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTEETDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVIFDALKEGVKKGFRGKEGAIIVDPARELKVLINSLLELLTEVGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSLQDAAGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIRNWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEREEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPALCSRIPQVTTHWLEILQALLLSPNQELQHRGTVVVLNMMQSSKEIAGTLMESEVLEILSVLAKGEESPVTRAAAACLEKAVEYRLIQPNQDGE
Protein: Lnk, isoform D (A0A0B4LHY5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Tyrosine-protein kinase hopscotch
- Insulin-like receptor
- Insulin receptor substrate 1
- E3 ubiquitin-protein ligase CBL
- Growth factor receptor-bound protein 2
Sequence:
MGGNSTGANTSAFSAGGYIGPTSASSHHSLGTSSAAAAAAAGSDLIPAPIGTGNAMGVSSYAYGGTSWEEFCERHARVAASDFAKACITYINGNLPPEEARNIQHRSFAQKFVESFSAHYDTEFFKRRSTLKSGAGSLDFEEEHEVPKLLSKSLLRRLSFKGLRKGKISLLQAFFHKNSDDLDGSGGSGKQSKTKLAKIVVECRKEGTVNNLTPESLDQPTGSQKWEKCRLVLVKAVGGYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEAESAEEMRSWLATIRYCMRTPPTQQPTIESDGVMASAMQTSPTLPSPNPIGGIQNPQYQQQRGSNGNLVGGGAPLTSSLSADSALGQGGATSASELNVINELGTSPTSGPPDIPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASNAAGGTASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHGSPPPAQNFLDQPHLRASNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRAVDNQYSFT
Protein: Macrophage stimulating 1 (Hepatocyte growth factor-like) (P70521)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGWLPLLLLLAQCSRALGQRSPLNDFQLLRGTELRNLLHPVVPGPWQEDVADAEECARRCGPLLDCRAFHYNMSSHGCQLLPWTQHSLRAQLHHSSLCDLFQKKDYVRTCIMDNGASYRGTVARTADGLPCQAWSRRFPNDHKYTPTPKNGLEENFCRNPDGDPRGPWCYTTNRSVRFQSCGIKSCREAVCVWCNGEDYRGEVDVTESGRECQRWDLQHPHSHPFHPEKFPDKALKDNYCRNPDASERPWCYTTDPNVEREFCDLPSCGPNLPPTTKGSKSQQRNKVKASNCFRGKGEDYRGTTNTTSAGVPCQRWDAQNPHQHRFVPEKYACKDLRENFCRNPDGSEAPWCFTSRPGLRVAFCYQIPRCTEEVVPEGCYHGSGEQYRGSVSKTRKGVQCQHWSSETPHKPQFTPTSAPHAGLEANFCRNPDGDSHGPWCYTLDPETLFDYCALKRCDDDQPPSILDPPVQVQFEKCGKRVDQSNRLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWVLTARQCIWSCHDPLTGYEVWLGTINQNPQPGEANLQRVSVAKTVCGPAGSQLVLLKLERPVILNHHVARICLPPEQYVVPPGTNCEIAGWGESKGTSNSTVLHVAKMKVISSQECNVKYRRRVQESEICTEGLLAPTGACEGDYGGPLACYTHDCWVLQGLIIPNRVCARPRWPAIFTRVSVFVDWINKVVQLE