wanglab/gogpt-training-data huggingface dataset:
Protein: Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) (P52799)
Organism: Homo sapiens (Human)
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
Interaction partners:
- Ephrin type-A receptor 4
- Ephrin type-B receptor 3
- Ephrin type-B receptor 1
- Ephrin type-B receptor 2
- Ephrin type-B receptor 4
- Ephrin type-A receptor 1
- Ephrin type-B receptor 6
- Regulator of G-protein signaling 3
- Ephrin type-A receptor 3
- Cytoplasmic protein NCK2
Sequence:
MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Protein: phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (A0A8I6A3Q2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MSLTARVSCSMLSCFGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHIACKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLSAGTNDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENAEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPGSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVSLEPWHSNPEGAEAVIESGVGSPQLTVGDVGLPPPLPSSQKDYLSNKPFKGHKSCSLSYKLLNTSVSWEMKNTSEIKVLEETEALAPGPPAREEQSRTSDGLGKPPEQCPEKEATSSLSNVSSKCGGACDFPGEPPQDSFTGTPQQPHLDSMQAVPIRCTPDHGQGSLCNPPSAASQTLQEPNTDLISQDPPGSMAGISYQEQPSSVSDLIYKKEDAGKRGSKNGQLVENPRFGKMPLELARKPISQSQISEFSFLGSNWDSFQGMMTSFPSGETTPRRLLAYGCCSKRPSNKHIRAAAPCFGGQWAQREGMKSPVCSSHSNGHCTGPGGKNNRMWFSSHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQHLKKPIATASS
Protein: Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) (A0A8I6ALZ8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR023869}.
Interaction partners:
Sequence:
MAVINNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVVSDLLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVKPKAKRKEEPSSIFQRQRVDALLIDLRQKFPPRFVQQKSGEKPVPVDQAKKEAEPLPETVKSEEKESAKSAQQTVSTKGPPEKRMRLQ
Protein: Calcium-dependent protein kinase 9 (EC 2.7.11.1) (Calmodulin-domain protein kinase CDPK isoform 9) (Q38868)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12913141, ECO:0000269|PubMed:15308754, ECO:0000269|PubMed:19029837}; Lipid-anchor {ECO:0000269|PubMed:12913141, ECO:0000269|PubMed:15308754, ECO:0000269|PubMed:19029837}.
Interaction partners:
- Respiratory burst oxidase homolog protein B
- Oxysterol-binding protein-related protein 1C
- Respiratory burst oxidase homolog protein C
Sequence:
MGNCFAKNHGLMKPQQNGNTTRSVEVGVTNQDPPSYTPQARTTQQPEKPGSVNSQPPPWRAAAAAPGLSPKTTTKSNSILENAFEDVKLFYTLGKELGRGQFGVTYLCTENSTGKKYACKSISKKKLVTKADKDDMRREIQIMQHLSGQPNIVEFKGAYEDEKAVNLVMELCAGGELFDRIIAKGHYTERAAASVCRQIVNVVKICHFMGVLHRDLKPENFLLSSKDEKALIKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLRRRYGKEVDIWSAGIILYILLSGVPPFWAETEKGIFDAILEGHIDFESQPWPSISSSAKDLVRRMLTADPKRRISAADVLQHPWLREGGEASDKPIDSAVLSRMKQFRAMNKLKKLALKVIAENIDTEEIQGLKAMFANIDTDNSGTITYEELKEGLAKLGSKLTEAEVKQLMDAADVDGNGSIDYIEFITATMHRHRLESNENLYKAFQHFDKDSSGYITIDELESALKEYGMGDDATIKEVLSDVDSDNDGRINYEEFCAMMRSGNPQQQQPRLF
Protein: Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (CDC25Mm) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) (P27671)
Organism: Mus musculus (Mouse)
Function: Promotes the exchange of Ras-bound GDP by GTP.
Interaction partners:
- GTPase HRas
- GTPase KRas
- Glutamate receptor ionotropic, NMDA 2B
- Calmodulin-1
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Transforming protein RhoA
- Ras-related protein R-Ras
Sequence:
MQKAIRLNDGHVVTLGLLAQKDGTRKGYLSKRSADNPKWQTKWFALLQNLLFYFESDSSPRPSGLYLLEGSICKRAPSPKRGTSSKESGEKQQHYFTVNFSNDSQKTLELRTEDAKDCDEWVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKTEVTITNLIKDNDRIQSSNKAGSADDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLMQMSLSEKSKSSRGRLGSLSTKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLDEPENLDDEAKGAGPEIEHLEFKIGVEPKDSLPFTVILVASTRQEKAAWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLELLFSSSHNAKLLYGDAPKSPRASRKFSSPPPLAIGTSSPSRRRKLSLNIPIITGGKALELASLGCSSDSYANIHSPISPFGKTTLDTGKLCMASSLPKTPEEIDVPATIPEKPGELSASRKHSSDVLKEESEDDQNHSDEDNTEVSPVKSPPTPKSFLNRTITEFPFFNYNNGILMTTCRDLVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRMSLANTGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQDFDTDDTLKYRVICFLEEVMHDPDLLTQERKAAANIIRTLTLEETTEQHSMLEEVILMTEGVKTEPFENHPALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEPKLPT
Protein: At2g32150/F22D22.10 (Haloacid dehalogenase-like hydrolase (HAD) superfamily protein) (Putative hydrolase) (Q9SKY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Guanosine deaminase
- Amino acid transporter AVT6A
- AT4g32020/F10N7_170
- ACT domain-containing protein ACR9
- Amino acid transporter AVT6D
- Probable protein phosphatase 2C 41
- WAT1-related protein At4g28040
- Cysteine-rich receptor-like protein kinase 42
- Formin-like protein
- CBS domain-containing protein CBSX3
Sequence:
MDFSPINCLIFDLDDTLYPLKTGIAPAVKKNIDDFLVEKFGFSESKASSLRVELFKTYGSTLAGLRALGHDVHPDEYHSFVHGRLPYGSIEPNNKLRNLLNKIKQRKIIFTNSDKNHAVKVLKKLGLEDCFEEMICFETMNPNLFGSTTRPDEYPVVLKPSLTAMDICIRVANVDPRRTVFLDDNIHNITAGKSVGLRTILVGRAEKTKDADYAVETVTEIATAVPEIWATATATGGFDVGGERIRRSKSELEGMASIAAVGA
Protein: Rap2ip protein (A1L117)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
EEFVNFAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLPDPPPPPRTGLIPGDHAPLAQGSKELTTALVNQWPSLSTLSRPEGASNSKLFRRHSFMSTEPLSAEASLSSDSQRLGEGKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS
Protein: A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein) (Q2M3C7)
Organism: Homo sapiens (Human)
Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm.
Interaction partners:
- Sphingosine kinase 1
Sequence:
MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLELG
Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) (Q4WCG5)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367007}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367007}.
Interaction partners:
- Dolichyl-phosphate-mannose--protein mannosyltransferase
- Dolichyl-phosphate-mannose--protein mannosyltransferase
- Extracellular developmental signal biosynthesis protein FluG
- Methyltransferase LaeA-like, putative
Sequence:
MSSSPSSSLRKRGGRKEAYSPLPSDDASSPLSSSKPSVASTNQSGWDYRLALVVLTILAFITRFYKISYPNEVVFDEVHFGKFASYYLQRTYFFDVHPPFGKLLFAFMGWLIGYDGHFLFDNIGDSYIDNKVPYVALRAMPATLGALTIPVVFLIMWESGYSLPACVLAAGLVLFDNAHVGEDRLILLDASLVLSMALSILCYVRFYKLRHEPFGRKWWKWLLLTGVSLSCVISTKYVGVFTFVTIGAAVLVDLWNLLDINRPSGALSMAHWTKHFAARAFALIIVPFFFYLFWFQVHFAILTRSGPGDDFMTPEFQETLSDNLMSAQSIGIQYYDTITIRHKDTKVFLHSHWEKYPLRYDDGRISSQGQQVTGYPFNDTNNHWQILPSVPYPETDRQGHSVKNGDIVQLRHVGTDTILLTHDVASPYYPTNQEFTTVSHELANGERHNDTLFEIKIENGKPQQEFRSLSSHFKLIHVPTRVAMWTHTTPLPEWAFKQAEINGNKNILQTSNLWFVDTIESLEENSPRAIKKERQVKHLPFWRKYLELQRAMFFHNNALTSSHPYASEPFQWPFLLRGVSFWTKNDTREQIYFLGNPIGWWIASSLLAVFVGVIGADQLSLRRGVDALEEIWGRGARSRLYNSTAFLFLCWAAHYFPFWLMGRQRFLHHYLPAHVASCMVAGALIEFIFNLQPISVARAVKEDDPTGKSKAHGSAGHFVTAKERMGRQSLIAGWVATLVILSLTIWGFCFFAPLTYGTPGLDVAGVNARKWLGYDLHFAK
Protein: Fimbrin (P54680)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to actin.
Interaction partners:
- Gelation factor
- Dynacortin
- Cortexillin-1
Sequence:
MTNFSESEISEFKASFNQFDENGDGQISALELQKILTKCGEKVTGVEVRDMIKEVDTDGNGSIDFKEFLQVMQKARQHSANASPAFASAVKKVGAVNTIGGYSGSTASGVQHSYSDEEKVAYIDWINNCLAKDVDLKSRLPIPEDGDKFFAACNDGLLLCKLINDAVPDTIDERVLNKKNLNAFRINENQVLCINSAKAIGCNVVNIGAGDLVEGRAHLIMGLTWQIIKIGLFARINLTNHPELYRLLHDGETIEDLLKLPVEEILLRWFNYHLAAAGSQRRVKNFSGDIKDSECYTILLKQIAPKDAGVETSALNISNLDQRAVKVLENADKLGCKKFLKPKDIVTGFQKLNLAFVANLFNTHPALEPVEDVVIIEETREEKTFRNWMNSLGVDPFVNNLYEGTYDGLILIQLFDKIYPGLVDHKKVNYPPYKAMGAEMKKIENCNYAIQLGKDCKYSLVGIDGKNVYDKNKTLTLSILWQLMRGHVISILTALSGSGKPIADADIVNWTNSKLSAAGKKQISGFKDSTISTGIPILDVIEAVRPGSVDPALVATSGSAEDNLLNAKLAVSTARKVGAVVFALPEDIVEVKPKMVLTLFASLWQVEMTK
Protein: Pirin-1 (AtPirin1) (Q9LX49)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in abscisic acid signal transduction. Plays a role in seed germination and early seedling development. Involved in the blue light (BL) signaling.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-binding protein alpha-1 subunit
- G-protein coupled receptor 1
- Regulator of G-protein signaling 1
- Transcription factor VOZ2
- Arogenate dehydratase 3, chloroplastic
- Protein THYLAKOID FORMATION 1
- Thioredoxin superfamily protein
- DNA ligase-like protein
- Putative BTB/POZ domain-containing protein At3g49970
- Acireductone dioxygenase 1-requiring) 1)
Sequence:
MTYENNSVPRIVIKKVLAKLEKEGEGAVVRNGITKIDQKLLDPFVLLVEFSFSLSAGFPDHPHRGFESVTYMLQGGIIHKDPKGHKGTIQAGDVQWMTAGRGIIHSEFPEEEVNNGLQLWINLPSTEKMTEPKYKELSSLDIPRAEENGVEVKVIAGDSMGIKSPVYTRTPTMFLDFTLKPGSQTHQTVPESWTAFAYIIEGDEGVFGSLNSSAISAHHVVVFGPGDLVSVWNKSTSRSLRFLLIAGEPIGEPVVQCGPFVMNSQAEIDMAFDDYQNAKNGFEMAKC
Protein: Apurinic-apyrimidinic endonuclease 1 (PfApn1) (EC 3.1.21.-) (Q8IE02)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base. Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER. Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:31386260}.
Interaction partners:
- Endonuclease III homolog lyase)
- Endonuclease/exonuclease/phosphatase family protein, putative
- DNA-
- DNA repair endonuclease XPF, putative
- Uracil-DNA glycosylase
- ERCC1 nucleotide excision repair protein, putative
- DNA repair protein RAD14, putative
- DNA-directed DNA polymerase
- DNA-
Sequence:
MFFSFYHSSFSSLSSFFFSFFSLLLYMLVLLQIFPKNYYEAGTLSIRVIRKNTFNHSYNNIKNIHYIHCGYPNIFNNCRNYYMNNFYNNNLSAPFKNKNNYMHIFFKIVEGNKKKKREHPFFKYLFHMNMLEKSGDKKNTVISKITESCQYGDIRKYMNMKKESLEEGEKNKSGEEYNKHVEQNNIKDEKIHFKDGTFIKSKEEEIENEKGGTICLKKEIQKNVLEINNNTYNNDTKYLSNPKGVTNKSKQSKKEIEKKKKKKNNNNNNNNNNKIKSEKSANDTKNIPPIPKNTEDRWNDYNKIKEYAKISNVYLGAHISASGGVQNAPINSFNISGLAFALFLKNQRKWESAALTNENIKQFEENCKKYNFDKNFILPHGSYLINLANPDKEKRDKSYLSFLDDIKRCEQLNIKLYNFHPGSTVGQCTVDEGIKNVADCINKVHKETNNVIIVLENSAGQKNSVGSKFEHLRDIINLVHDKDRIGVCLDTCHTFAAGYNIKTFENFDNVMKQFDDIVNVKYLKAVHLNDSKSDIGSGLDRHENIGKGKLTMDTFKYIMKSKYFKNIPIILETPDITNDESIYKYEIQNLYKLYFEK
Protein: Candida glabrata strain CBS138 chromosome E complete sequence (Q6FVH3)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- non-specific serine/threonine protein kinase
Sequence:
MRIDRALTTAAAAGYLRLPFTKITDNSLAKRADDDYLNVQLDNEQIFYGVEVSIGSDKQNMTLLVDTGSSDFWVLGAQNPYCKSNRGKKPKKKDQPSSVDPGRNGYPTKAEAIPYAERTFDCSDFKTFNSSSSNTFKSNDTDFFITYGDGSYVEGTWGTDQVALAGQTLENVTFAVAELTNNSYGLLGIGLPELESSITIDTAQLTNTSSVKKNPYMNFPESLKLNKLINKVVYSIYLNRTNDKFGSILFGAVDHNRYDGNLTTVPLVFSNRDFGTPRPNELMVTLNGMSFEATDGNVTQILNATSKFPALLDTGSTDTHLPVDVYNALAESTNGTYDQTQNKIRIPKCLSKKDKTILNFSLGGVNIGVPYKEMVKKIKGKCYINVAPTGSDFAILGDDVIRYAYMVFDLEDREISLAQASFNDTLPEDIEVVVSTIPGATRASAYSETYSPTFAVPSASSSGNTSSNGSTNLTRRFERRDIPLENKGVPTSLKGSVAAILLLVLWIA
Protein: Chromosome segregation in meiosis protein 3 (Q59X26)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Topoisomerase 1-associated factor 1
- DNA replication licensing factor MCM2
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM4
- DNA replication initiation factor
- Chromatin-binding protein
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM3
- Replication protein A subunit
Sequence:
MSYVMDETEEGINIDNTQHDLELDRDSSTQQPAQTHEDDGDLLGLDKPIKLKTRAKIAKVDNQRIFNHNGIPLLVKTHSKLLRTLKKNDKNFYSEPRSSISKSQKFEHEYENLSSVLQFYQLWCHGLFPKATFKDCIHLIRALGARSPQLRLYRRELIAAELHKLKVAKGIIADENQDAPSIPEEENTTDPSNEEWNSMHMSALVPGSSNKNGLFVDSNSNEDFETTNEVNAAASLADKDALSTDDKAEQTNAITSDTHNNDVDSDDPFSDDDDINIDAHTENLHPASGTQHQDRPKETTEENEDLELELMREYGA
Protein: Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28) (O14645)
Organism: Homo sapiens (Human)
Function: May play a dynamic role in flagellar motility.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:27120127}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:31178125}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6GN86}. Cytoplasm {ECO:0000269|PubMed:36792588}.
Interaction partners:
- Dynein axonemal intermediate chain 2
- Dynein axonemal heavy chain 5
- Dynein axonemal assembly factor 1
- Dynein axonemal intermediate chain 1
- Dynein regulatory complex subunit 4
- Coiled-coil domain-containing protein 39
- Coiled-coil domain-containing protein 40
- Zinc finger MYND domain-containing protein 10
- Radial spoke head protein 4 homolog A
- Radial spoke head protein 9 homolog
Sequence:
MIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK
Protein: Zinc finger protein 43 (Zinc finger protein 39) (Zinc finger protein HTF6) (Zinc finger protein KOX27) (P17038)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGPLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLRRYKNCEHKNVHLKKDHKSVDECKVHRGGYNGFNQCLPATQSKIFLFDKCVKAFHKFSNSNRHKISHTEKKLFKCKECGKSFCMLPHLAQHKIIHTRVNFCKCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWSSRLTTHKKNYTRYKLYKCEECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTHNKIHTGEKLYKPEDVTVILTTPQTFSNIK
Protein: nicotinamidase (EC 3.5.1.19) (Nicotinamide deamidase) (Q7YTI0)
Organism: Caenorhabditis elegans
Interaction partners:
- Nicotinate phosphoribosyltransferase
- Nicotinamide-nucleotide adenylyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Glutamine-dependent NAD
- Molybdopterin synthase catalytic subunit
- Arginase
- 5-oxoprolinase
Sequence:
MGVVQNEQDIREKMKNELISLVNEIDLIPELDRLLDDFIENKTWNEDTQELFTRVVLKPFTTLRTSLLVVDFQNDFVTGSLSIKEGDAEQDPLEALPHVNNLLENLNWNMIVYTQDWHPSNHISFFEHARNPDRELAPEDKSRKLRPFDIVRFVKPVSTIQVLYPSHCIQGGWGSQLHLGLQRIDGAHYIKKGADVYVDAYSAFSDNCGIKQSELEMLLRKNDINAVIGCGLAYDICVMHTLKDASKHGFLTCIVKSGSKGLSSLKMDEANKMFQKRGVAIIDDEMAQLISRREAFPIEWIRLLVHQAQSELHGKK
Protein: Short-chain dehydrogenase, putative (Q38AS0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIFLLFISFIGWVLWSLYSLLSYRRVSVAGKTVVITGGSVGIGKHLALHFLRLGATVHVWDDNKEKLSQLSKEALLIPSPRPTKSANCDTEGLTETSANELEGNDCLKTVVVDLSNRFHLHRLVKQVGTVHIVVNAALNVSSKAFLDHADNAIERILHVNALCPLILARAFLPAMLERRDGYFVTITDANGLLGNASQPDFAASQWAAVGAHESIQMLIRENGCCGKVRTTLLCPYNVVSSQPTLLRTPSPFSSSRVMNTADAANTAEGQSVNTIRRSRILGYFLSIFRRPVTPEEAAEACVWAITHGVERLYIPYSLLFLTLFRFLPVPWFMWVISPSTQSTNVETSKGNCPSESDSSRSSSEK
Protein: Engulfment and cell motility 1 (ced-12 homolog, C. elegans) (Engulfment and cell motility protein 1 isoform X2) (A0A2R8RS12)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPPPADIVKVAIEWPGAFPKLMEIDQKKPLSAIIKEVCEGWNLPNPETYALQNADATNFYITEKNRNNIKNGSILRLTTSAAQMAQQLHERIQSSSMDMKLDALKDLANSSRDITFAQEFINLDGISLLTQMVESGTDFGDLLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASYVCKSAMDTAVLQRSLAILESMVLNSQDLYQKVAQEITIGQLIPHLQGTDQDIQTYTIAVINALFLKAPEEKRQFDGDNVNILDCPLTEMAHILAQKQLRSIILSNVIRSNKPINDEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDVECESNNSGSIEKRKSMYTRDYKKLGFINHVNPAVDFTQIPPGMLALDNMLYFARHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSENCHDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQITRALTIKPNSLDQFKSRLQNLSYTEILKLRQSERMNQEDFQSRPILELREKIQPEIMELIKQQRLNRLCEGTCFRKISSRRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSVLYESDEYLNFIAPDKHEYCVWTDGLNALLGKEMSSEFTRSDMDTLLNMEMKLRLLDLENIQIPEVPPPIPKEPSNYDFVYDCN
Protein: DNA ligase B (LigB) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]) (P9WNV5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Interaction partners:
- DNA ligase A
- DNA polymerase I
- Beta sliding clamp
- Putative lipoprotein LppK
- Non-homologous end joining protein Ku
- 5'-3' exonuclease
- Peptide transporter CstA
- DNA polymerase IV 2
- Probable acyl-CoA dehydrogenase FadE22
- DNA ligase D polymerase domain-containing protein
Sequence:
MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY