wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q17RV3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMTQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVTVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
Protein: Dipeptidyl-peptidase 5 (DPP5) (EC 3.4.14.-) (MER236725) (C3J8X2)
Organism: Porphyromonas endodontalis (strain ATCC 35406 / DSM 24491 / JCM 8526 / CCUG 16442 / BCRC 14492 / NCTC 13058 / HG 370) (Bacteroides endodontalis)
Function: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Prefers Ala and hydrophobic residues at the P1 position, and has no preference for P2 residues. Shows the highest dipeptidyl peptidase activity toward the synthetic substrate Lys-Ala-methylcoumaryl-7-amide (Lys-Ala-MCA). Is likely involved in amino acid metabolism and bacterial growth/survival of asaccharolytic P.endodontalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.
Subcellular location: Periplasm {ECO:0000250|UniProtKB:B2RIT0}.
Interaction partners:
- Probable ATP-binding protein YbiT
Sequence:
MKRTILSLLAAVSLAIPVYAAGYSDGNPTQQTSQSSMMTPEMLLTMARIGGFSLSPNGKQVVYSVSLPSIQDNKAKTQLFFVNSDGSGRKALTDGTRTAVSPRWIEDGKRIAYLTVIEGEMQLVSILPDGTDQRQVTRIPGGITGYLYSQDGKQLVYTADIKLPNEAKDRNPDLDKISGRVITDLMYKHWDEWVETAPHTFVASLAQQPITQGKDLLEGELFEAPMKPHSDESDIAITPDGKGIAYASRKKTGLEYSISTNSDIYYYDLTTGTTTNLTEGMMGYDTHPSFSPDGKYMTWCSMERDGYESDLIRLFLLDRTTGEKTYLTEGFEYNVEQPTWSQDGKSIYFIACVEAESHLYELTLKNKKIRRITQGQMDYVGFDLQGTTLVAARQSMLAPTDLYRIDLKKGTATAITKENESTLAQLGDIRCEKRWMNTTNGEKMLVWVLYPANFDASKKYPSILYCQGGPQSTISQFWSYRWNPRIMAENGYIVILPNRHGVPGFGKAWNEQISGDYGGQNMRDYLTAADEMKKESYIDPNGMGCVGASYGGFSVYWLAGHHEKRFNCFIAHAGIFNLEAQYLETEEKWFANWDMGGAPWEKSNATAQRTFATSPHLFVDKWDTPILIIHGERDYRILASQGMMAFDAARMHGVPTEMLLYPDENHWVLQPQNAVLWQRTFFRWLDRWLKK
Protein: NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein) (O35604)
Organism: Mus musculus (Mouse)
Function: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (By similarity).
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:O15118}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15118}. Lysosome membrane {ECO:0000269|PubMed:21896731, ECO:0000269|PubMed:22065762, ECO:0000269|PubMed:27551080}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15118}.
Interaction partners:
- NPC intracellular cholesterol transporter 2
- Oxysterol-binding protein-related protein 5
- GTP-binding protein 1
- Neutral amino acid transporter 9
- Pancreatic secretory granule membrane major glycoprotein GP2
- Sterol regulatory element-binding protein 2
- Sigma intracellular receptor 2
- Protein Aster-B
- Sterol regulatory element-binding protein 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Sequence:
MGAHHPALGLLLLLLCPAQVFSQSCVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYIYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQRAWAWEKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTYERYRGTERERLLNF
Protein: Pollen allergen Phl p 5b (Allergen Phl p Vb) (allergen Phl p 5b) (Q40963)
Organism: Phleum pratense (Common timothy)
Function: Has ribonuclease activity. May be involved in host-pathogen interactions.
Interaction partners:
Sequence:
AAAAVPRRGPRGGPGRSYTADAGYAPATPAAAGAAAGKATTEEQKLIEDINVGFKAAVAAAASVPAADKFKTFEAAFTSSSKAAAAKAPGLVPKLDAAYSVAYKAAVGATPEAKFDSFVASLTEALRVIAGALEVHAVKPVTEEPGMAKIPAGELQIIDKIDAAFKVAATAAATAPADDKFTVFEAAFNKAIKESTGGAYDTYKCIPSLEAAVKQAYAATVAAAPQVKYAVFEAALTKAITAMSEVQKVSQPATGAATVAAGAATTAAGAASGAATVAAGGYKV
Protein: Disease resistance protein RRS1B (Probable WRKY transcription factor 16) (WRKY DNA-binding protein 16) (Q9FL92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Acts also as a disease resistance protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae. Heterodimerization with RPS4B is required to form a functional complex to recognize AvrRps4 and to mediate the hypersensitive response.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Disease resistance protein
Sequence:
MTESEQIVYISCIEEVRYSFVSHLSKALQRKGVNDVFIDSDDSLSNESQSMVERARVSVMILPGNRTVSLDKLVKVLDCQKNKDQVVVPVLYGVRSSETEWLSALDSKGFSSVHHSRKECSDSQLVKETVRDVYEKLFYMERIGIYSKLLEIEKMINKQPLDIRCVGIWGMPGIGKTTLAKAVFDQMSGEFDAHCFIEDYTKAIQEKGVYCLLEEQFLKENAGASGTVTKLSLLRDRLNNKRVLVVLDDVRSPLVVESFLGGFDWFGPKSLIIITSKDKSVFRLCRVNQIYEVQGLNEKEALQLFSLCASIDDMAEQNLHEVSMKVIKYANGHPLALNLYGRELMGKKRPPEMEIAFLKLKECPPAIFVDAIKSSYDTLNDREKNIFLDIACFFQGENVDYVMQLLEGCGFFPHVGIDVLVEKSLVTISENRVRMHNLIQDVGRQIINRETRQTKRRSRLWEPCSIKYLLEDKEQNENEEQKTTFERAQVPEEIEGMFLDTSNLSFDIKHVAFDNMLNLRLFKIYSSNPEVHHVNNFLKGSLSSLPNVLRLLHWENYPLQFLPQNFDPIHLVEINMPYSQLKKLWGGTKDLEMLKTIRLCHSQQLVDIDDLLKAQNLEVVDLQGCTRLQSFPATGQLLHLRVVNLSGCTEIKSFPEIPPNIETLNLQGTGIIELPLSIVKPNYRELLNLLAEIPGLSGVSNLEQSDLKPLTSLMKISTSYQNPGKLSCLELNDCSRLRSLPNMVNLELLKALDLSGCSELETIQGFPRNLKELYLVGTAVRQVPQLPQSLEFFNAHGCVSLKSIRLDFKKLPVHYTFSNCFDLSPQVVNDFLVQAMANVIAKHIPRERHVTGFSQKTVQRSSRDSQQELNKTLAFSFCAPSHANQNSKLDLQPGSSSMTRLDPSWRNTLVGFAMLVQVAFSEGYCDDTDFGISCVCKWKNKEGHSHRREINLHCWALGKAVERDHTFVFFDVNMRPDTDEGNDPDIWADLVVFEFFPVNKQRKPLNDSCTVTRCGVRLITAVNCNTSIENISPVLSLDPMEVSGNEDEEVLRVRYAGLQEIYKALFLYIAGLFNDEDVGLVAPLIANIIDMDVSYGLKVLAYRSLIRVSSNGEIVMHYLLRQMGKEILHTESKKTDKLVDNIQSSMIATKEIEITRSKSRRKNNKEKRVVCVVDRGSRSSDLWVWRKYGQKPIKSSPYPRSYYRCASSKGCFARKQVERSRTDPNVSVITYISEHNHPFPTLRNTLAGSTRSSSSKCSDVTTSASSTVSQDKEGPDKSHLPSSPASPPYAAMVVKEEDMEQWDNMEFDVDVEEDTFIPELFPEDTFADMDKLEENSQTMFLSRRSSGGNMEAQGKNSSDDREVNLPSKILNR
Protein: COMPASS component SPP1 (Complex proteins associated with SET1 protein SPP1) (Set1C component SPP1) (Suppressor of PRP protein 1) (Q03012)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- COMPASS component SWD3
- COMPASS component SHG1
- COMPASS component SDC1
- COMPASS component BRE2
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- COMPASS component SWD1
- COMPASS component SWD2
- Histone H3
- Recombination protein 107
- Histone H4
Sequence:
MSLPQWCPPHSTLKRNPTTGEDVYCICKRPDYGELMVGCDGCDDWFHFTCLHIPEQFKDLVFSFYCPYCQAGITGKNKDAIINGEGSLPKTLWKRKCRISDCYKPCLQDSKYCSEEHGREFVNDIWSRLKTDEDRAVVKKMVEQTGHIDKFKKFGQLDFIDNNIVVKTDDEKEIFDQIVVRDMTLKTLEDDLQEVQEISLPLFKKKLELLEVYLGWLDNVYTEMRKLDDDAASHVECGKEDSKGTKRKKKKNSSRSRARKNICGYCSTYERIPCSVEEFVRDFGSNEEATKIHEVCTKWKCNRHLDWVSTNQEQYLQQIDSLESMQERLQHLIQARKKQLNIQYYEEILRRGL
Protein: G2/M-phase specific E3 ubiquitin protein ligase (G3V483)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLIPALQISDSESVGLEDGIEQSAYLTESKMNESKPGDSQNLACVFCRKHDDCPNKYGEKKTKEKWNLTVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
Protein: TLDc domain protein (Q682Q6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASCAISNSFHTVTFKTLKRISPYNSLFGWNSGKKIDNIRPPQQPAYHDDVEIPFSLSMVNKTFLKGRELKCCYKASIDGFGATKFHERCDFKGPCVIIAYTKDKSFKFGGFSPEGYRSTDDYYDTFDAFLFYWLEDCDDPIVLPKVGGSGAALFDYARGGPQFGADGLLIGPPLAPVMGGFAGPDTNSGIGDLRVAKSRLGLSYAKRKDGKESIFGDENKVSLDDVLVFCSPYIASLY
Protein: Ferrochelatase Che1 (P71751)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Adenosine 5'-phosphosulfate reductase
- Sulfite reductase [ferredoxin]
- uroporphyrinogen-III C-methyltransferase
- Probable gamma-glutamyltranspeptidase GgtB
Sequence:
MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTIAPQLVLTAHGSKDPRSAANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCRGAAVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLGEDIRLVSALHERLTELGVSPFDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAAVTTAFITRPEASLADATDRLRRHGARRMVIAPWLLAPGILSDRVRGYAREAGIAMAQPLGAHPMVAATMWDRYRQAVAGRIAA
Protein: Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1) (Q2ABP3)
Organism: Rattus norvegicus (Rat)
Function: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Post-GPI attachment to proteins factor 3
- GPI alpha-1,6-mannosyltransferase 2
- Metallophosphoesterase 1
- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- Glucosaminyl-phosphatidylinositol-acyltransferase PIGW
- GPI ethanolamine phosphate transferase 3
- GPI ethanolamine phosphate transferase 1
- Phosphatidylinositol glycan anchor biosynthesis, class T
- GPI-anchor transamidase
- GPI inositol-deacylase
Sequence:
MYQVPLTLDRDGTLVRLRFTMVALITVCCPLVAFFFCILWSLLFHFKETTSTHCGVPNYLPSVSSAIGGEVPQRYVWRFCIGLHSAPRFLTAFAYWNHYLSCASPCPGYRLLCRLNFSLNVVENLALLVLTYVSSSEDFTIHENAFIVFIAASLSYMLLTCILWRLTKKHTVSQEDRKSYSWKQRLFIINFISFFSALAVYFRHNMYCEAGVYTIFAILEYTVVLTNMAFHMTAWWDFGNKELLITSQPEEKRF
Protein: Cytochrome b6-f complex subunit 4 (17 kDa polypeptide) (Q6ENE3)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01344}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01344}.
Interaction partners:
- Cytochrome b6
- Cytochrome c oxidase subunit 3
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- NAD
- Cytochrome b6-f complex subunit 5
- Cytochrome f
- Cytochrome f
- Photosystem I iron-sulfur center
- Uncharacterized protein
- Cytochrome b559 subunit alpha
Sequence:
MGVSKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPTGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAVALWLGIGATLPIEKSLTLGLF
Protein: Acetyl-CoA decarbonylase/synthase complex subunit epsilon 1 (ACDS complex subunit epsilon 1) (ACDS complex carbon monoxide dehydrogenase subunit epsilon 1) (ACDS CODH subunit epsilon 1) (P72020)
Organism: Methanosarcina thermophila
Function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.
Interaction partners:
Sequence:
MVDTTKNTKLFTSYGVTTSKAINPDMAAKMISKAKRPLFVVGTGVLRPEILDRAVKIAKKANLPIAATGSSLNGFLDKDVDAKYINVHQLGFYLTDPAWPGLDGKGNYDTIIILEFKKYYINQVLSGTKNFSKVKSISIGKDYIQNATMSFGNISREEHFAALDELIDLL
Protein: RNA helicase (EC 3.6.4.13) (Q583S9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ATP-dependent RNA helicase
- ATP-dependent RNA helicase
- ATP-dependent RNA helicase
Sequence:
MNQKRCEGGKHQTVDANIRRFPMGGSPQASQLQQMLPHASVRAACSPGFFPPAPMYGHPLPMPGGVWWPPVLLPRAPVQQEFTNSLPRGNDSRQKCENMPASDNSDTKRGVLDIVDNQKGIGFPENFKRLKKHLQSMVKAFVDDPTAHELSFPPTLSAAGRQQVHKFAHTFGLFHKSSGSQNERFLTLRKFNKTSEEQGRQFLIANGVRVRTEGYQGAQRLPDEYIRPKVSNINLLVGPLLKRMFRDLKLRGEQRQGGRQLTVVQPGLGNVPTSKVPRHRYAELQRFRVTLPAFRQQGAILNAVKISDIVVISGDTGCGKTTQIPQMLYDAGIFNKDLQIVCTQPRRVSALSVAQRVSEERGEACGNSCGYIIRFDNITSSETRIVYMTTGILLRRLRTDPQLSDVSCLIVDEVHERDVETDFCLLLLRDRIIDQRRNPGAYANHIKVVVMSATIQVEKIISYFSGVTVGETIPVIKIPGTLHPVRECYMEDVLQWLQMPLSTLASMKLPNNALSMQSTGNNTEDMAKRSVYEKIKEAVDTKLGFDSQAHVPYDIVVKLIGHIHRSSQHLSESILVFLPGWQAISRVANMIRMSNVSRELSVLQLHSSLTAEEQRRVFYRAPKGYRKVVLSTNIAETSITIDDIVYVVDSCLTKVSSYDPAANTSALTAEFISRANGLQRRGRAGRCRPGVCIHLLPRSSYEALPEFLPPEIMRTPLEEVCLLAKALRPEETCVEVLSRALDVPSEYSTKHATNFLKDIGAFTPEAEQLTSLGRALSRLPVHPLLGKMLLAAACFGVLDPVATIAAFLSGKSPFLNTPNQRGDLQKAVDAIDNGFLSDHMSVLKLFDGWKRSGCSPEYAIHNFADQAVLRSISRTKNQLLRFVENSALLRRTKNPVKFASRHSDNLGLIRLVVLWSLYPRIASLEYRSKRSGGQPEIICWDDKHCQLAATSVLARKRQNKYGDRAFIFFNERMFLETNLTIFDATAVTPVELALCLRELTVKSVKEIPPSLFTDHESRMTPVFPYVPNGEKESENMAALFFDNCKKMYLTNVDVATCLRDVRECMDYYLALSINRVRADLFPEELSCAIAYAIGYPLASFKSGNTVVGDSSESEFSETGEQAGSSRVMEGGNIHVEADSCSDSSGDIPEMVIDEFENFDLTDAEMRQISISLGNLAVFNRYTASHQFLSAETTATRGEGEHDAVAGGGQKRVEYGESQGPEATGESEGNAPVTEEGGFVTRDEEAPDTAQE
Protein: Ig-like domain-containing protein (Q3U531)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRMGTMVPGTLLILLAASPGQTQTCPGSHSLKYFYTALSRPAISEPWYIAVGYLDDTQFVRFDSAGETGTYKLLSPWVEQEGPEYWARETEIVTSNAQFFRENLQTMLDYYNLSQNAADMAAEITRSKWEQAGYTELRRTYLEGPCKDSLLRYLENRKKTQECTDPPKTHVTHHPRPEGYVTLRCWALGFYPAHITLTWQLNGEELIQDMELVETRPAGDGTFQKWAAVVVPSGEEQKYTCHVYHEGLPEPLTLRWEPPQSSMPTRTIVRAVLGAMVILGVMRGSGMMWMRKNKGGNRDDNTAACQNEREHLSLSAGDESDALGVEAGLKELPTAPPLVP
Protein: Ceramide-1-phosphate transfer protein (CPTP) (Glycolipid transfer protein domain-containing protein 1) (GLTP domain-containing protein 1) (Q5TA50)
Organism: Homo sapiens (Human)
Function: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23863933}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}. Cell membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}; Cytoplasmic side {ECO:0000269|PubMed:23863933}. Endosome membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}. Nucleus outer membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}.
Interaction partners:
- Glycolipid transfer protein
Sequence:
MDDSETGFNLKVVLVSFKQCLDEKEEVLLDPYIASWKGLVRFLNSLGTIFSFISKDVVSKLRIMERLRGGPQSEHYRSLQAMVAHELSNRLVDLERRSHHPESGCRTVLRLHRALHWLQLFLEGLRTSPEDARTSALCADSYNASLAAYHPWVVRRAVTVAFCTLPTREVFLEAMNVGPPEQAVQMLGEALPFIQRVYNVSQKLYAEHSLLDLP
Protein: Transmembrane protein (Q388F9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCTTRCLHIGNKGCGCTPALVSIIGGFPISLTFLVLMQCALYSSAIGEEEALLVGRSCHLNSSDGGGVCHGFSKSNVRRPLHRSRQPLAAHNVSTVYKLGNIVCRGTCDSATRRGSLHHTRIFGVANRTLSSQYPAAPSRDGEASDDMLFEISKDRQSLRLRLVTSIGNMAVRFVTFEPLRSITNKTLEGGSLLTSASVPTAANPSFNTSCLDRQGRDGSATTIWKFDDRKLTNRLDTQSDAYKSGENYYHKFGGNHRDCDVYRLDPCKYAPMLTPPGAISGGYERSLGIHWKLHINDCDATWIGDISLNYLLQMRNSSTGEPLFTLIDGNILVGSVYLQVVEPVSWSLPSKGVVFGYQPYNLRLQLQSTTAAVTRMPQALNHRSIQSGTATSHKRMGNKRHLPGSSKRSSSLVHDVKSPNVTLSSLIGVWSTSSCDNITGRQLYSYNFLVRLRRRSPVNSTAASGAQSSLHTAAAPRVTGVEMINSSLTVPIVHNHSACPGEMHNKSRYGELPQPARVTEVHFERVQVVGVLRRHSKDSEPGDDVLNVSATGRVVTRSTKPSVSGSAKDAFVLRILFEDGRSDLINIRQGIRISGFGFEVYAELCRLPLQWWSLGRGGQLPLAAQLEARSVLEDVIRGRAKKGNGCTTEGNRSYGSNDRVHVSLNVRKTGDVPFQVTKVSLHRLVLSVDAAAVSGTFRCNRTTKKGRALQFLLDSESHHRVEKEEWVNGEDSSSRVRCRSSSEYASLLHYRRTANDSPHQHADLRHSPSTASPSFSFIPGALIRRGFSGRVEFHFKAVLRVSENDTNSEFLLTEGFRFTVEASPKSTVLKTAIPSPSGDDNSTTAGNTQFVTISKGLAVVLYVVLTGVIAAAAAVGLLLEWRFHMTIKALRRRMSESAVPIDVEQPPDCDLGAKEKETC
Protein: Protein Wnt-11 (P49339)
Organism: Gallus gallus (Chicken)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-7
- Frizzled-6
- Frizzled-4
- Frizzled-1
- Frizzled-3
- Frizzled-2
- Frizzled-10
- Low-density lipoprotein receptor-related protein
- Frizzled-9
- Wnt inhibitory factor 1
Sequence:
MKPSPQFFLAAFLSLILQTGICYGIKWIALSKTPSSLALNQTQHCKQLEGLVVSQVQLCRSNLELMQTIIQAAREVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARACTTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKKSGSQANKLMHLHNSEVGRQVLKASLEMKCKCHGVSGSCSIKTCWKGLQELRDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK
Protein: Tyrosine-protein kinase receptor (EC 2.7.10.1) (B7SNG4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRLRTLIVLVASVYTVCNCQQTNGEICSSKDIRNNVTNLRVLENCTVIEGHLKILLMFTTKPEDFRGLSYPKLTVVTDYLLLFRVYGLESLSDLFPNLTVVRGNNLFFNYALVLFEMLQLKEIGLHSLMNITRGAVRVEKNPDLCYLSTLDWSMILDSVEDNYIVANKNDRECGDICPGTVLGKTTCPLTTINGDFSERCWNQKYCQRMCPSSCKHRACTKDNQCCHDQCLGGCLEPHSSNKCVACRNFMHNNMCVEKCPHGFYTFKGWRCVSFSFCQELHNKCKQGKGDCHEYVIHNGACIPECPSGYTTVNSTTLNCTPCAGLCPKVCMGLKTVDSVTAAQALRGCTVINGSLVINIRGGNNIAAELEANLGQLEEITGYLTVRHSYALVSLSFLRKLRIIHGETQEVGNYSFYALDNQNLRQLWDWSKHNLTIQQGRMFFHHNSKLCMSEIRRMEEVTGTKNRQTKNDIVSKTNGDQASCESKVLKFTRISTLSDKIIIKWEAFWPPDFRDLLGFMVLYKEAPYKNVTEFDGQDACGSNSWVIADVDPPPRATEGKEHEPGYLIFPLKPWTQYAIMVKTQLSASDEHQVHGAKSEIIYVRTNATKPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHYLVFCQQQPEASELYKFDYCQKGMKLPTRAPTQVDNEEEQKWNQTEEQGPDSRCCACPKTEKQLKKEAEETEYRKTFENYLHNEVFELRPSRQRRSLVGIANRTSSRLFTTPSSLPNGSATRSPEEEAEANKISLIVQAKESTVISNLRHFTSYQIEIHACNHGSDPTRCSMAAYVSARTMPEEKADDIVGKITCEVFEYSVHIRWIEPKAPNGMIILYEVHYKRLGDTEELHHCVSRKNYIADGGCKLRVVHPGNYTVRIRATSLAGNGSWTEPTHFYVQDLRVDPSNVLKIVIGPVICFFLLLLLCVGFYIVKKKQTEGPTGRLYTSPNPEYFSPDEVYEPDEWEVPREKITLLRELGQGSFGMVYEGNGKDIVKGESQTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTHGDLKSFLRSLRPDSENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEVSTLAEQPYQGLSNEQVLKFVMEGGYLDRPDNCADRLHNLMQMCWHYNPKMRPTFQEIIEMLREDLHPSFQEVSFFYSEENKPPETEEFDMDLENMESIPLDPSSYSQRECCLDGDEGSSVGLRGSYEEHVPYTHMNGGKKNGRILSLPRSTPS
Protein: Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (Q8R415)
Organism: Rattus norvegicus (Rat)
Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8NFJ6}; Multi-pass membrane protein.
Interaction partners:
- Prokineticin-2
- Prokineticin-1
- NMDA receptor synaptonuclear signaling and neuronal migration factor
Sequence:
MGDQNGNTSFAPDLNPPQDHVSLLPLNYSYGDYDIPLDDDEDVTKTQTFFAAKIVIGVALAGIMLVCGVGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKRMNYQTASFLIALVWMVSILIAIPSAYFTTETILVIVKNQEKLFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTLVVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLLLHWRPSHYGSKSSADLDLKTSGVPATEEVDCIRLK